625587	0	1,1,3-tricyano-2-amino-1-propene	14,46	TCAP	48,52	1,1,3-tricyano-2-amino-1-propene	TCAP	MESH:C025201	107055299	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of 1,1,3-tricyano-2-amino-1-propene -LRB- TCAP -RRB- on RNA synthesis in chick_embryo_sciatic_nerves .
16206828	0	1,1-dioxides	37,49	leukocyte_elastase	73,91	1,1-dioxides	leukocyte elastase	null	1991	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	2,4,5-Triphenylisothiazol-3 -LRB- 2H -RRB- - one 1,1-dioxides as inhibitors of human leukocyte_elastase .
20605713	0	1,10-Phenanthroline	0,19	glucose_oxidase	49,64	1,10-Phenanthroline	glucose oxidase	MESH:C025205	54363	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	1,10-Phenanthroline derivatives as mediators for glucose_oxidase .
9180259	0	1,10-phenanthroline	39,58	glutathione_synthetase	13,35	1,10-phenanthroline	glutathione synthetase	MESH:C025205	14854(Tax:10090)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of glutathione_synthetase by 1,10-phenanthroline .
16482620	0	1,2,3,4,6-penta-O-galloyl-beta-D-glucose	0,40	heme_oxygenase-1	54,70	1,2,3,4,6-penta-O-galloyl-beta-D-glucose	heme oxygenase-1	MESH:C013185	3162	Chemical	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|amod|END_ENTITY	1,2,3,4,6-penta-O-galloyl-beta-D-glucose up-regulates heme_oxygenase-1 expression by stimulating Nrf2 nuclear translocation in an extracellular_signal-regulated_kinase-dependent manner in HepG2 cells .
21516456	0	1,2,3,4-diepoxybutane	33,54	gpt	62,65	1,2,3,4-diepoxybutane	gpt	MESH:C007366	100760506	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Genotoxicity of stereoisomers of 1,2,3,4-diepoxybutane in the gpt gene of Chinese_hamster ovary AS52 cells .
14730096	0	1,2,3,4-tetrahydro-gamma-carbolines	88,123	5-HT2A	39,45	1,2,3,4-tetrahydro-gamma-carbolines	5-HT2A	null	29595(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY activity|nummod|END_ENTITY	Synthesis , in vitro and in vivo 5-HT1A / 5-HT2A serotonin receptor activity of new hybrid 1,2,3,4-tetrahydro-gamma-carbolines with 1 - -LRB- 2-methoxyphenyl -RRB- piperazine moiety .
19346127	0	1,2,3,4-tetrahydroisoquinolin-1-ones	21,57	GPR40	98,103	1,2,3,4-tetrahydroisoquinolin-1-ones	GPR40	null	266607(Tax:10116)	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Synthesis and SAR of 1,2,3,4-tetrahydroisoquinolin-1-ones as novel G-protein-coupled_receptor_40 -LRB- GPR40 -RRB- antagonists .
3351861	0	1,2,3,4-tetrahydroisoquinoline	55,85	phenylethanolamine_N-methyltransferase	103,141	1,2,3,4-tetrahydroisoquinoline	phenylethanolamine N-methyltransferase	MESH:C014843	5409	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Synthesis and evaluation of 3-substituted analogues of 1,2,3,4-tetrahydroisoquinoline as inhibitors of phenylethanolamine_N-methyltransferase .
22078410	0	1,2,3,6-tetrahydropyridines	84,111	monoamine_oxidase_A	47,66	1,2,3,6-tetrahydropyridines	monoamine oxidase A	null	4128	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Time-dependent slowly-reversible inhibition of monoamine_oxidase_A by N-substituted 1,2,3,6-tetrahydropyridines .
22079028	0	1,2,3-triazole	20,34	SGLT2	46,51	1,2,3-triazole	SGLT2	CHEBI:35562	6524	Chemical	Gene	analogs|amod|START_ENTITY analogs|nmod|END_ENTITY	Facile synthesis of 1,2,3-triazole analogs of SGLT2 inhibitors by ` click chemistry ' .
21324681	0	1,2,3-triazoles	7,22	caspase-3	52,61	1,2,3-triazoles	caspase-3	null	836	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Isatin 1,2,3-triazoles as potent inhibitors against caspase-3 .
14642597	0	1,2,4-thiadiazole	0,17	Cathepsin_B	27,38	1,2,4-thiadiazole	Cathepsin B	CHEBI:39471	1508	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	1,2,4-thiadiazole : a novel Cathepsin_B inhibitor .
24881000	0	1,2,4-thiadiazole	98,115	cathepsin_B	83,94	1,2,4-thiadiazole	cathepsin B	CHEBI:39471	1508	Chemical	Gene	derivatives|amod|START_ENTITY insight|nmod|derivatives insight|nmod|mechanism mechanism|nmod|inhibition inhibition|nmod|END_ENTITY	Theoretical insight into the mechanism for the inhibition of the cysteine protease cathepsin_B by 1,2,4-thiadiazole derivatives .
22958416	0	1,2,4-triazol-5-ones	19,39	tumor_necrosis_factor-alpha	43,70	1,2,4-triazol-5-ones	tumor necrosis factor-alpha	null	7124	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Discovery of novel 1,2,4-triazol-5-ones as tumor_necrosis_factor-alpha inhibitors for the treatment of neuropathic_pain .
23867390	0	1,2,4-triazole	62,76	heme_oxygenase-1	80,96	1,2,4-triazole	heme oxygenase-1	MESH:C045575	3162	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Evaluation of novel aryloxyalkyl derivatives of imidazole and 1,2,4-triazole as heme_oxygenase-1 -LRB- HO-1 -RRB- inhibitors and their antitumor properties .
24445310	0	1,2,4-triazolones	75,92	CB1	96,99	1,2,4-triazolones	CB1	null	1268	Chemical	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	Design , synthesis , biological evaluation , and comparative docking study of 1,2,4-triazolones as CB1 receptor selective antagonists .
7473585	0	1,2-Diarylcyclopentenes	0,23	cyclooxygenase-2	37,53	1,2-Diarylcyclopentenes	cyclooxygenase-2	null	29527(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	1,2-Diarylcyclopentenes as selective cyclooxygenase-2 inhibitors and orally active anti-inflammatory agents .
10445049	0	1,2-Diarylimidazoles	0,20	cyclooxygenase-2	38,54	1,2-Diarylimidazoles	cyclooxygenase-2	null	5743	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	1,2-Diarylimidazoles as inhibitors of cyclooxygenase-2 : a quantitative structure-activity relationship study .
10715153	0	1,2-Dibenzamidobenzene	0,22	factor_Xa	43,52	1,2-Dibenzamidobenzene	factor Xa	null	2159	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	1,2-Dibenzamidobenzene inhibitors of human factor_Xa .
1902664	0	1,2-diacylglycerol	28,46	Thrombin	0,8	1,2-diacylglycerol	Thrombin	MESH:C011439	2147	Chemical	Gene	production|amod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Thrombin induces a biphasic 1,2-diacylglycerol production in human platelets .
23416008	0	1,2-diaryl-1H-benzimidazole	19,46	JNK3	62,66	1,2-diaryl-1H-benzimidazole	JNK3	null	5602	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	3D-QSAR studies of 1,2-diaryl-1H-benzimidazole derivatives as JNK3 inhibitors with protective effects in neuronal cells .
19356043	0	1,2-diarylethane	39,55	melanocortin_4_receptor	56,79	1,2-diarylethane	melanocortin 4 receptor	null	25635(Tax:10116)	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|amod|END_ENTITY	An indirect screen for brain uptake of 1,2-diarylethane melanocortin_4_receptor antagonists in rats .
7671343	0	1,2-dibromo-3-chloropropane	14,41	glutathione_S-transferases	45,71	1,2-dibromo-3-chloropropane	glutathione S-transferases	MESH:C007318	373156	Chemical	Gene	Metabolism|nmod|START_ENTITY Metabolism|nmod|END_ENTITY	Metabolism of 1,2-dibromo-3-chloropropane by glutathione_S-transferases .
22301079	0	1,2-dibromoethane	38,55	EDB	57,60	1,2-dibromoethane	EDB	MESH:D015946	8673	Chemical	Gene	-RSB-|amod|START_ENTITY -RSB-|compound|END_ENTITY	Biodegradation of ethylene_dibromide -LRB- 1,2-dibromoethane -LSB- EDB -RSB- -RRB- in microcosms simulating in situ and biostimulated conditions .
1358580	0	1,2-diethyl-3-hydroxypyridin-4-one	24,58	CP94	60,64	1,2-diethyl-3-hydroxypyridin-4-one	CP94	MESH:C068543	25394(Tax:10116)	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY pharmacokinetics|appos|END_ENTITY	The pharmacokinetics of 1,2-diethyl-3-hydroxypyridin-4-one -LRB- CP94 -RRB- in rats .
17203232	0	1,2-dimethylhydrazine	74,95	MUC2	11,15	1,2-dimethylhydrazine	MUC2	MESH:D019813	24572(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|END_ENTITY	Intestinal MUC2 and gastric M1/MUC5AC in preneoplastic_lesions induced by 1,2-dimethylhydrazine in rat : a sequential analysis .
8763837	0	1,2-dithiole-3-thione	30,51	DT-diaphorase	13,26	1,2-dithiole-3-thione	DT-diaphorase	MESH:C049325	18104(Tax:10090)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of DT-diaphorase by 1,2-dithiole-3-thione and increase of antitumour activity of bioreductive agents .
17303331	0	1,2-dithiole-3-thione	22,43	heat_shock_protein	73,91	1,2-dithiole-3-thione	heat shock protein	MESH:C049325	290549(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|nmod|END_ENTITY	The thiol antioxidant 1,2-dithiole-3-thione stimulates the expression of heat_shock_protein 70 in dopaminergic PC12 cells .
9579829	0	1,2-dithiole-3-thiones	30,52	DT-diaphorase	13,26	1,2-dithiole-3-thiones	DT-diaphorase	null	1728	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of DT-diaphorase by 1,2-dithiole-3-thiones in human tumour and normal cells and effect on anti-tumour activity of bioreductive agents .
22474169	0	1,2-dithiole-3-thiones	36,58	Fyn	0,3	1,2-dithiole-3-thiones	Fyn	null	2534	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Fyn inhibition by cycloalkane-fused 1,2-dithiole-3-thiones enhances antioxidant capacity and protects mitochondria from oxidative injury .
18252807	0	1,2-dithiole-3-thiones	79,101	S6K1	128,132	1,2-dithiole-3-thiones	S6K1	null	6198	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Abrogation of hyperosmotic_impairment of insulin signaling by a novel class of 1,2-dithiole-3-thiones through the inhibition of S6K1 activation .
15727882	0	1,2-naphthoquinone	70,88	PTP1B	104,109	1,2-naphthoquinone	PTP1B	MESH:C040756	5770	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Comparative molecular similarity indices analysis -LRB- CoMSIA -RRB- studies of 1,2-naphthoquinone derivatives as PTP1B inhibitors .
22129745	0	1,2-naphthoquinone	42,60	Peroxiredoxin_6	0,15	1,2-naphthoquinone	Peroxiredoxin 6	MESH:C040756	9588	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Peroxiredoxin_6 is a molecular target for 1,2-naphthoquinone , an atmospheric electrophile , in human pulmonary epithelial A549 cells .
17878162	0	1,2-naphthoquinone	57,75	epidermal_growth_factor_receptor	143,175	1,2-naphthoquinone	epidermal growth factor receptor	MESH:C040756	1956	Chemical	Gene	transactivation|amod|START_ENTITY transactivation|nmod|END_ENTITY	Chemical knockdown of protein-tyrosine phosphatase 1B by 1,2-naphthoquinone through covalent modification causes persistent transactivation of epidermal_growth_factor_receptor .
1295905	0	1,25-Dihydroxy-vitamin-D3	0,25	TGF-beta1	81,90	1,25-Dihydroxy-vitamin-D3	TGF-beta1	MESH:D002117	7040	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|effect effect|nmod|END_ENTITY	1,25-Dihydroxy-vitamin-D3 enhances antiproliferative effect and transcription of TGF-beta1 on human keratinocytes in culture .
10363987	0	1,25-Dihydroxycholecalciferol	0,29	p21	106,109	1,25-Dihydroxycholecalciferol	p21	MESH:D002117	12575(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|growth growth|nmod|END_ENTITY	1,25-Dihydroxycholecalciferol -LRB- 1,25-D3 -RRB- inhibits the growth of squamous_cell_carcinoma and down-modulates p21 -LRB- Waf1/Cip1 -RRB- in vitro and in vivo .
11322770	0	1,25-Dihydroxycholecalciferol	0,29	p21	56,59	1,25-Dihydroxycholecalciferol	p21	MESH:D002117	1026	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	1,25-Dihydroxycholecalciferol enhances butyrate-induced p21 -LRB- Waf1/Cip1 -RRB- expression .
10192761	0	1,25-dihydroxycholecalciferol	0,29	ICAM-1	41,47	1,25-dihydroxycholecalciferol	ICAM-1	MESH:D002117	3383	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	1,25-dihydroxycholecalciferol stimulates ICAM-1 expression of human alveolar macrophages in healthy controls and patients with sarcoidosis .
6547601	0	1,25-dihydroxycholecalciferol	53,82	PK1	113,116	1,25-dihydroxycholecalciferol	PK1	MESH:D002117	24651(Tax:10116)	Chemical	Gene	cells|amod|START_ENTITY cells|appos|END_ENTITY	Production of C-24 - and C-23-oxidized metabolites of 1,25-dihydroxycholecalciferol by cultured kidney cells -LRB- LLC PK1 -RRB- and their presence in kidney in vivo .
9435420	0	1,25-dihydroxycholecalciferol	132,161	insulin-like_growth_factor-I	22,50	1,25-dihydroxycholecalciferol	insulin-like growth factor-I	MESH:D002117	3479	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of short-term insulin-like_growth_factor-I -LRB- IGF-I -RRB- or growth_hormone -LRB- GH -RRB- treatment on bone metabolism and on production of 1,25-dihydroxycholecalciferol in GH-deficient adults .
117883	0	1,25-dihydroxycholecalciferol	29,58	parathyroid_hormone	116,135	1,25-dihydroxycholecalciferol	parathyroid hormone	MESH:D002117	24694(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY Comparison|nmod|effects Comparison|nmod|END_ENTITY	Comparison of the effects of 1,25-dihydroxycholecalciferol , prostaglandin_E2 , and osteoclast-activating_factor with parathyroid_hormone on the ultrastructure of osteoclasts in cultured long bones of fetal rats .
1333519	0	1,25-dihydroxycholecalciferol	65,94	vitamin_D_receptor	35,53	1,25-dihydroxycholecalciferol	vitamin D receptor	MESH:D002117	24873(Tax:10116)	Chemical	Gene	rats|nmod|START_ENTITY END_ENTITY|nmod|rats	Short-term regulation of the renal vitamin_D_receptor in rats by 1,25-dihydroxycholecalciferol is calcium insensitive .
22336385	0	1,3,4-Thiadiazole	0,17	iNOS	57,61	1,3,4-Thiadiazole	iNOS	MESH:C058949	4843	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|inhibitors inhibitors|nmod|END_ENTITY	1,3,4-Thiadiazole derivatives as selective inhibitors of iNOS versus nNOS : Synthesis and structure-activity dependence .
17574410	0	1,3,4-oxadiazole	41,57	EP1	58,61	1,3,4-oxadiazole	EP1	CHEBI:46810	5731	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|compound|END_ENTITY	Identification and optimization of novel 1,3,4-oxadiazole EP1 receptor antagonists .
19320275	0	1,3,4-thiadiazole	13,30	aminopeptidase_N	46,62	1,3,4-thiadiazole	aminopeptidase N	MESH:C058949	290	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Synthesis of 1,3,4-thiadiazole derivatives as aminopeptidase_N inhibitors .
26691756	0	1,3,5-triarylpyrazoline	100,123	COX-2	172,177	1,3,5-triarylpyrazoline	COX-2	null	4513	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Synthesis , cyclooxygenase inhibition , anti-inflammatory evaluation and ulcerogenic liability of new 1,3,5-triarylpyrazoline and 1,5-diarylpyrazole derivatives as selective COX-2 inhibitors .
1328183	0	1,3-Butadiene	0,13	myeloperoxidase	33,48	1,3-Butadiene	myeloperoxidase	MESH:C031763	4353	Chemical	Gene	oxidation|amod|START_ENTITY oxidation|nmod|END_ENTITY	1,3-Butadiene oxidation by human myeloperoxidase .
26669707	0	1,3-Diaryl-pyridones	13,33	VEGFR-2	44,51	1,3-Diaryl-pyridones	VEGFR-2	null	3791	Chemical	Gene	START_ENTITY|nmod|Inhibitors Inhibitors|compound|END_ENTITY	Discovery of 1,3-Diaryl-pyridones as Potent VEGFR-2 Inhibitors : Design , Synthesis and Biological Evaluation .
20672970	0	1,3-b-D-glucan	107,121	Granulocyte_macrophage_colony-stimulating_factor	0,48	1,3-b-D-glucan	Granulocyte macrophage colony-stimulating factor	null	12981(Tax:10090)	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Granulocyte_macrophage_colony-stimulating_factor is required for cytokine induction by a highly 6-branched 1,3-b-D-glucan from Aureobasidium pullulans in mouse-derived splenocytes .
12581496	0	1,3-beta-D-glucan	28,45	IFN-gamma	0,9	1,3-beta-D-glucan	IFN-gamma	MESH:C480180	15978(Tax:10090)	Chemical	Gene	induction|amod|START_ENTITY induction|amod|END_ENTITY	IFN-gamma induction by SCG , 1,3-beta-D-glucan from Sparassis crispa , in DBA/2 mice in vitro .
10925840	1	1,3-butadiene	123,136	hprt	92,96	1,3-butadiene	hprt	MESH:C031763	15452(Tax:10090)	Chemical	Gene	genes|nmod|START_ENTITY genes|amod|END_ENTITY	Part III : In vivo mutation of the endogenous hprt genes of mice and rats by 1,3-butadiene and its metabolites .
117809	0	1,3-diamino-2-propanol	68,90	ornithine_decarboxylase	108,131	1,3-diamino-2-propanol	ornithine decarboxylase	MESH:C017203	4953	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	The inhibition of induction of microsomal monooxygenase activity by 1,3-diamino-2-propanol , an inhibitor of ornithine_decarboxylase .
10657958	0	1,3-diaminopropane	22,40	ornithine_decarboxylase	45,68	1,3-diaminopropane	ornithine decarboxylase	MESH:C009475	24609(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Inhibitory effects of 1,3-diaminopropane , an ornithine_decarboxylase inhibitor , on rat two-stage urinary_bladder_carcinogenesis initiated by N-butyl-N - -LRB- 4-hydroxybutyl -RRB- nitrosamine .
1730525	0	1,3-diaminopropane	57,75	ornithine_decarboxylase	22,45	1,3-diaminopropane	ornithine decarboxylase	MESH:C009475	24609(Tax:10116)	Chemical	Gene	inhibitor|dep|START_ENTITY inhibitor|amod|END_ENTITY	Attenuating effect of ornithine_decarboxylase inhibitor -LRB- 1,3-diaminopropane -RRB- on bombesin enhancement of gastric_carcinogenesis induced by N-methyl-N ' - nitro-N-nitrosoguanidine .
3934184	0	1,3-diaminopropane	126,144	ornithine_decarboxylase	14,37	1,3-diaminopropane	ornithine decarboxylase	MESH:C009475	4953	Chemical	Gene	effects|amod|START_ENTITY comparison|nmod|effects Inhibition|dep|comparison Inhibition|nmod|activity activity|amod|END_ENTITY	Inhibition of ornithine_decarboxylase activity and cell growth by diamines : a comparison between the effects of two homologs , 1,3-diaminopropane and 1,4-diaminobutane -LRB- putrescine -RRB- .
22106038	0	1,3-dinitrobenzene	52,70	adenosine_deaminase	20,39	1,3-dinitrobenzene	adenosine deaminase	MESH:C017906	100	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Mixed inhibition of adenosine_deaminase activity by 1,3-dinitrobenzene : a model for understanding cell-selective neurotoxicity in chemically-induced energy_deprivation_syndromes in brain .
15109637	0	1,3-oxazinan-2-ones	15,34	LFA-1	66,71	1,3-oxazinan-2-ones	LFA-1	null	3683	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Statin-derived 1,3-oxazinan-2-ones as submicromolar inhibitors of LFA-1 / ICAM-1 interaction : stabilization of the metabolically labile vanillyl side chain .
10406636	0	1,4,5,6-tetrahydropyridazine	28,56	neuraminidase	82,95	1,4,5,6-tetrahydropyridazine	neuraminidase	null	4758	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Synthesis and evaluation of 1,4,5,6-tetrahydropyridazine derivatives as influenza neuraminidase inhibitors .
12375632	0	1,4-benzodiazepines	60,79	CCK2_receptor	108,121	1,4-benzodiazepines	CCK2 receptor	null	887	Chemical	Gene	studies|amod|START_ENTITY studies|nmod|END_ENTITY	Combinatorial solid phase synthesis of multiply substituted 1,4-benzodiazepines and affinity studies on the CCK2_receptor -LRB- part_1 -RRB- .
12105121	0	1,4-butanediol	101,115	CD-1	119,123	1,4-butanediol	CD-1	MESH:C039681	111334(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|compound|END_ENTITY	Enzyme and receptor antagonists for preventing toxicity from the gamma-hydroxybutyric_acid precursor 1,4-butanediol in CD-1 mice .
1872891	0	1,4-diamines	14,26	ornithine_decarboxylase	34,57	1,4-diamines	ornithine decarboxylase	null	4953	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Regulation by 1,4-diamines of the ornithine_decarboxylase activity induced by ornithine in perifused tumor cells .
15080918	0	1,4-diazepane	43,56	factor_Xa	72,81	1,4-diazepane	factor Xa	MESH:C545228	2159	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Synthesis and biological activity of novel 1,4-diazepane derivatives as factor_Xa inhibitor with potent anticoagulant and antithrombotic activity .
20303626	0	1,4-dihydropyridine	24,43	BACE-1	59,65	1,4-dihydropyridine	BACE-1	MESH:C038806	23621	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Design and synthesis of 1,4-dihydropyridine derivatives as BACE-1 inhibitors .
14501143	0	1,4-diphenyl-2-butene	70,91	MAO_B	120,125	1,4-diphenyl-2-butene	MAO B	null	4129	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Polystyrene microbridges used in sitting-drop crystallization release 1,4-diphenyl-2-butene , a novel inhibitor of human MAO_B .
3020176	0	1,4-dithiothreitol	57,75	histamine_H1-receptor	15,36	1,4-dithiothreitol	histamine H1-receptor	CHEBI:18320	100135539(Tax:10141)	Chemical	Gene	Enhancement|nmod|START_ENTITY Enhancement|nmod|activity activity|amod|END_ENTITY	Enhancement of histamine_H1-receptor agonist activity by 1,4-dithiothreitol in guinea-pig cerebellum and cerebral cortex .
14735505	0	1,4-naphthoquinone	24,42	CO2	46,49	1,4-naphthoquinone	CO2	MESH:C035342	717	Chemical	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Enthalpy of solution of 1,4-naphthoquinone in CO2 + n-pentane in the critical region of the binary mixture : mechanism of solubility enhancement .
20554444	0	1,5-Diarylimidazoles	0,20	COX-2	61,66	1,5-Diarylimidazoles	COX-2	null	17709(Tax:10090)	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	1,5-Diarylimidazoles with strong inhibitory activity against COX-2 catalyzed PGE2 production from LPS-induced RAW 264.7 cells .
15961192	0	1,5-diarylpyrazoles	70,89	COX-2	41,46	1,5-diarylpyrazoles	COX-2	null	4513	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Synthesis and SAR/3D-QSAR studies on the COX-2 inhibitory activity of 1,5-diarylpyrazoles to validate the modified pharmacophore .
25579901	0	1,5-dihydroxyanthraquinone	70,96	b-cyclodextrin	116,130	1,5-dihydroxyanthraquinone	b-cyclodextrin	CHEBI:37501	285440	Chemical	Gene	START_ENTITY|nmod|presence presence|nmod|END_ENTITY	A highly selective dual mode detection of Fe -LRB- 3 + -RRB- ion sensing based on 1,5-dihydroxyanthraquinone in the presence of b-cyclodextrin .
21939430	0	1,5-naphthyridine	6,23	PI3K	24,28	1,5-naphthyridine	PI3K	CHEBI:36625	5293	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Novel 1,5-naphthyridine PI3K inhibitors , an evaluation of WO2011075628 .
22356552	0	1,6-napthyridine	35,51	Syk	52,55	1,6-napthyridine	Syk	null	6850	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Evaluation of WO2011134971 , chiral 1,6-napthyridine Syk kinase inhibitors .
16165349	0	1,7-naphthyridine-3-carbonitriles	56,89	TNF-alpha	30,39	1,7-naphthyridine-3-carbonitriles	TNF-alpha	null	7124	Chemical	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Inhibition of Tpl2 kinase and TNF-alpha production with 1,7-naphthyridine-3-carbonitriles : synthesis and structure-activity relationships .
23872422	0	1,8-Cineol	0,10	p65	51,54	1,8-Cineol	p65	MESH:C010087	5970	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|translocation translocation|nmod|END_ENTITY	1,8-Cineol inhibits nuclear translocation of NF-kB p65 and NF-kB-dependent transcriptional activity .
23192000	0	1,8-cineole	0,11	TRPA1	69,74	1,8-cineole	TRPA1	MESH:C010087	8989	Chemical	Gene	antagonist|nsubj|START_ENTITY antagonist|nmod|END_ENTITY	1,8-cineole , a TRPM8 agonist , is a novel natural antagonist of human TRPA1 .
23192000	0	1,8-cineole	0,11	TRPM8	15,20	1,8-cineole	TRPM8	MESH:C010087	79054	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	1,8-cineole , a TRPM8 agonist , is a novel natural antagonist of human TRPA1 .
12490407	0	1,8-diaminooctane	11,28	Rev	40,43	1,8-diaminooctane	Rev	MESH:C008697	155908(Tax:11676)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|system system|compound|END_ENTITY	Effects of 1,8-diaminooctane on the FIV Rev regulatory system .
17942307	0	1,8-naphthyridine	4,21	CB2	51,54	1,8-naphthyridine	CB2	CHEBI:36628	1269	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|agonists agonists|nummod|END_ENTITY	New 1,8-naphthyridine and quinoline derivatives as CB2 selective agonists .
24853961	0	1,9-pyrazoloanthrones	24,45	c-Jun_N-terminal_kinase	85,108	1,9-pyrazoloanthrones	c-Jun N-terminal kinase	null	5599	Chemical	Gene	effect|amod|START_ENTITY effect|nmod|END_ENTITY	Alkyl chain substituted 1,9-pyrazoloanthrones exhibit prominent inhibitory effect on c-Jun_N-terminal_kinase -LRB- JNK -RRB- .
10617610	0	1-Acyldihydroxyacetone-phosphate	0,32	Ayr1p	44,49	1-Acyldihydroxyacetone-phosphate	Ayr1p	null	854682(Tax:4932)	Chemical	Gene	reductase|amod|START_ENTITY reductase|appos|END_ENTITY	1-Acyldihydroxyacetone-phosphate reductase -LRB- Ayr1p -RRB- of the yeast Saccharomyces_cerevisiae encoded by the open reading frame YIL124w is a major component of lipid particles .
19171484	0	1-Amido-1-phenyl-3-piperidinylbutanes	0,37	CCR5	40,44	1-Amido-1-phenyl-3-piperidinylbutanes	CCR5	null	1234	Chemical	Gene	START_ENTITY|dep|antagonists antagonists|nummod|END_ENTITY	1-Amido-1-phenyl-3-piperidinylbutanes - CCR5 antagonists for the treatment of HIV .
21677062	0	1-Aminobenzotriazole	0,20	N-acetyltransferase	89,108	1-Aminobenzotriazole	N-acetyltransferase	MESH:C033020	116631(Tax:10116)	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	1-Aminobenzotriazole , a known cytochrome P450 inhibitor , is a substrate and inhibitor of N-acetyltransferase .
22353212	0	1-Bromopropane	0,14	cyclooxygenase-2	28,44	1-Bromopropane	cyclooxygenase-2	MESH:C118559	19225(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	1-Bromopropane up-regulates cyclooxygenase-2 expression via NF-kB and C/EBP activation in murine macrophages .
16615997	0	1-Deoxymannojirimycin	0,21	alpha1,2-mannosidase	27,47	1-Deoxymannojirimycin	alpha1,2-mannosidase	MESH:D017485	10905	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	1-Deoxymannojirimycin , the alpha1,2-mannosidase inhibitor , induced cellular endoplasmic_reticulum_stress in human hepatocarcinoma cell 7721 .
21909392	0	1-EBIO	22,28	CFTR	69,73	1-EBIO	CFTR	MESH:C102635	1080	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|function function|nmod|END_ENTITY	The K + channel opener 1-EBIO potentiates residual function of mutant CFTR in rectal biopsies from cystic_fibrosis patients .
26631491	0	1-Methylnicotinamide	31,51	Apolipoprotein_E	55,71	1-Methylnicotinamide	Apolipoprotein E	MESH:C024058	11816(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Antiatherosclerotic Effects of 1-Methylnicotinamide in Apolipoprotein_E / Low-Density_Lipoprotein_Receptor-Deficient Mice : A Comparison with Nicotinic_Acid .
15923196	0	1-Oleoyl-2-acetylglycerol	0,25	5-lipoxygenase	37,51	1-Oleoyl-2-acetylglycerol	5-lipoxygenase	MESH:C038237	240	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|amod|END_ENTITY	1-Oleoyl-2-acetylglycerol stimulates 5-lipoxygenase activity via a putative -LRB- phospho -RRB- lipid binding site within the N-terminal C2-like domain .
3124835	0	1-Palmitoyl-2-thiopalmitoyl_phosphatidylcholine	0,47	phospholipase_A2	92,108	1-Palmitoyl-2-thiopalmitoyl phosphatidylcholine	phospholipase A2	MESH:C054735	406141(Tax:7460)	Chemical	Gene	START_ENTITY|appos|substrate substrate|nmod|END_ENTITY	1-Palmitoyl-2-thiopalmitoyl_phosphatidylcholine , a highly specific chromogenic substrate of phospholipase_A2 .
26590508	0	1-Piperazinylphthalazines	0,25	VEGFR-2	39,46	1-Piperazinylphthalazines	VEGFR-2	null	3791	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	1-Piperazinylphthalazines as potential VEGFR-2 inhibitors and anticancer agents : Synthesis and in vitro biological evaluation .
24999749	0	1-alaninechlamydocin	25,45	HDAC	9,13	1-alaninechlamydocin	HDAC	null	9734	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	A potent HDAC inhibitor , 1-alaninechlamydocin , from a Tolypocladium sp .
3576519	0	1-alkyl-2-acyl-GPC	14,32	thrombin	82,90	1-alkyl-2-acyl-GPC	thrombin	MESH:C036761	2147	Chemical	Gene	Metabolism|nmod|START_ENTITY Metabolism|nmod|END_ENTITY	Metabolism of 1-alkyl-2-acyl-GPC in human platelets in response to stimulation by thrombin .
3355850	0	1-alkyl-2-arachidonoyl-sn-glycero-3-phosphocholine	14,64	phospholipase_A2	150,166	1-alkyl-2-arachidonoyl-sn-glycero-3-phosphocholine	phospholipase A2	null	151056	Chemical	Gene	Hydrolysis|nmod|START_ENTITY Hydrolysis|nmod|END_ENTITY	Hydrolysis of 1-alkyl-2-arachidonoyl-sn-glycero-3-phosphocholine , a common precursor of platelet-activating factor and eicosanoids , by human platelet phospholipase_A2 .
20642445	0	1-aminobenzotriazole	45,65	CYP2B6	13,19	1-aminobenzotriazole	CYP2B6	MESH:C033020	1555	Chemical	Gene	expression|nmod|START_ENTITY expression|nsubj|Induction Induction|nmod|END_ENTITY	Induction of CYP2B6 and CYP3A4 expression by 1-aminobenzotriazole -LRB- ABT -RRB- in human hepatocytes .
10640292	0	1-aminobenzotriazole	102,122	cytochrome_P-450	74,90	1-aminobenzotriazole	cytochrome P-450	MESH:C033020	25251(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Potentiation of oxygen-induced lung_injury in rats by the mechanism-based cytochrome_P-450 inhibitor , 1-aminobenzotriazole .
2276091	0	1-aminobenzotriazole	29,49	cytochrome_P-450	121,137	1-aminobenzotriazole	cytochrome P-450	MESH:C033020	100379244(Tax:10141)	Chemical	Gene	activity|amod|START_ENTITY activity|amod|dependent dependent|amod|END_ENTITY	N-aralkylated derivatives of 1-aminobenzotriazole as isozyme-selective , mechanism-based inhibitors of guinea_pig hepatic cytochrome_P-450 dependent monooxygenase activity .
2566467	0	1-aminobenzotriazole	86,106	cytochrome_P-450	50,66	1-aminobenzotriazole	cytochrome P-450	MESH:C033020	100328948(Tax:9986)	Chemical	Gene	substrates|xcomp|START_ENTITY substrates|nsubj|Inhibition Inhibition|nmod|bioactivation bioactivation|nmod|suicide suicide|amod|END_ENTITY	Inhibition of 3-methylindole bioactivation by the cytochrome_P-450 suicide substrates 1-aminobenzotriazole and alpha-methylbenzylaminobenzotriazole .
7114850	0	1-aminobenzotriazole	145,165	cytochrome_P-450	36,52	1-aminobenzotriazole	cytochrome P-450	MESH:C033020	4051	Chemical	Gene	tuberosus|nmod|START_ENTITY inactivation|nmod|tuberosus inactivation|dep|inactivation inactivation|nmod|enzymes enzymes|amod|END_ENTITY	Autocatalytic inactivation of plant cytochrome_P-450 enzymes : selective inactivation of cinnamic_acid 4-hydroxylase from Helianthus tuberosus by 1-aminobenzotriazole .
7316983	0	1-aminobenzotriazole	74,94	cytochrome_P-450	32,48	1-aminobenzotriazole	cytochrome P-450	MESH:C033020	4051	Chemical	Gene	alkylation|nmod|START_ENTITY alkylation|nmod|group group|amod|END_ENTITY	Autocatalytic alkylation of the cytochrome_P-450 prosthetic haem group by 1-aminobenzotriazole .
8035335	0	1-aminobenzotriazole	29,49	cytochrome_P-450	130,146	1-aminobenzotriazole	cytochrome P-450	MESH:C033020	100379244(Tax:10141)	Chemical	Gene	derivatives|nmod|START_ENTITY inhibitors|nsubj|derivatives inhibitors|acl|guinea_pig guinea_pig|xcomp|END_ENTITY	N-aralkylated derivatives of 1-aminobenzotriazole are potent isozyme - and lung-selective mechanism-based inhibitors of guinea_pig cytochrome_P-450 in vivo .
9920346	0	1-aminobenzotriazole	39,59	cytochrome_P450	4,19	1-aminobenzotriazole	cytochrome P450	MESH:C033020	25251(Tax:10116)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	The cytochrome_P450 suicide inhibitor , 1-aminobenzotriazole , sensitizes rats to zymosan-induced toxicity .
10080689	0	1-aminocyclopropane-1-carboxylate	33,66	ACS6	77,81	1-aminocyclopropane-1-carboxylate	ACS6	CHEBI:30526	826730(Tax:3702)	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	A multi-responsive gene encoding 1-aminocyclopropane-1-carboxylate synthase -LRB- ACS6 -RRB- in mature Arabidopsis leaves .
17630291	4	1-aminocyclopropane-1-carboxylic_acid	592,629	CS-ACS2	645,652	1-aminocyclopropane-1-carboxylic acid	CS-ACS2	CHEBI:18053	101212728	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Therefore , the expression of a 1-aminocyclopropane-1-carboxylic_acid synthase gene , CS-ACS2 , was examined in cucumber flower buds at different stages of development .
15539472	0	1-aminocyclopropane-1-carboxylic_acid	19,56	MPK6	69,73	1-aminocyclopropane-1-carboxylic acid	MPK6	CHEBI:18053	818982(Tax:3702)	Chemical	Gene	synthase|amod|START_ENTITY synthase|nmod|END_ENTITY	Phosphorylation of 1-aminocyclopropane-1-carboxylic_acid synthase by MPK6 , a stress-responsive mitogen-activated protein kinase , induces ethylene biosynthesis in Arabidopsis .
3007977	0	1-anilino-8-naphthalene_sulphonate	19,53	C1q	65,68	1-anilino-8-naphthalene sulphonate	C1q	null	712	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	The interaction of 1-anilino-8-naphthalene_sulphonate with human C1q .
974107	0	1-anilino-8-naphthalenesulfonate	15,47	antithrombin	92,104	1-anilino-8-naphthalenesulfonate	antithrombin	MESH:C027132	462	Chemical	Gene	START_ENTITY|nmod|III III|compound|END_ENTITY	The binding of 1-anilino-8-naphthalenesulfonate , heparin , salicylate and caprylate by human antithrombin III .
16298130	0	1-aryloxy-3-piperidinylpropan-2-ols	50,85	5-HT1A_receptor	96,111	1-aryloxy-3-piperidinylpropan-2-ols	5-HT1A receptor	null	3350	Chemical	Gene	START_ENTITY|nmod|activities activities|amod|END_ENTITY	Advances toward new antidepressants beyond SSRIs : 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A_receptor antagonism/SSRI activities .
12237534	0	1-arylsulfonyl-3-piperazinone	28,57	factor_Xa	75,84	1-arylsulfonyl-3-piperazinone	factor Xa	null	2159	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Synthesis and evaluation of 1-arylsulfonyl-3-piperazinone derivatives as a factor_Xa inhibitor II .
15056953	0	1-arylsulfonyl-3-piperazinone	28,57	factor_Xa	73,82	1-arylsulfonyl-3-piperazinone	factor Xa	null	2159	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Synthesis and evaluation of 1-arylsulfonyl-3-piperazinone derivatives as factor_Xa inhibitors IV .
15056966	0	1-arylsulfonyl-3-piperazinone	28,57	factor_Xa	73,82	1-arylsulfonyl-3-piperazinone	factor Xa	null	2159	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Synthesis and evaluation of 1-arylsulfonyl-3-piperazinone derivatives as factor_Xa inhibitors III .
17077550	0	1-arylsulfonyl-3-piperazinone	28,57	factor_Xa	73,82	1-arylsulfonyl-3-piperazinone	factor Xa	null	2159	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Synthesis and evaluation of 1-arylsulfonyl-3-piperazinone derivatives as factor_Xa inhibitors V .
17268108	0	1-arylsulfonyl-3-piperazinone	28,57	factor_Xa	73,82	1-arylsulfonyl-3-piperazinone	factor Xa	null	2159	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|inhibitors inhibitors|compound|END_ENTITY	Synthesis and evaluation of 1-arylsulfonyl-3-piperazinone derivatives as factor_Xa inhibitors -LRB- 1-6 -RRB- VI .
11886805	0	1-benzopyran-4-one	11,29	aldose_reductase	45,61	1-benzopyran-4-one	aldose reductase	CHEBI:72013	231	Chemical	Gene	derivatives|amod|START_ENTITY Binding|nmod|derivatives Binding|nmod|END_ENTITY	Binding of 1-benzopyran-4-one derivatives to aldose_reductase : a free energy perturbation study .
20121113	0	1-benzyl-1H-imidazoles	60,82	aldosterone_synthase	110,130	1-benzyl-1H-imidazoles	aldosterone synthase	null	1585	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Synthesis , biological evaluation , and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone_synthase -LRB- CYP11B2 -RRB- .
16759108	0	1-benzyl-5-phenyltetrazole	74,100	P2X7	101,105	1-benzyl-5-phenyltetrazole	P2X7	null	5027	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|compound|END_ENTITY	Structure-activity relationship studies on a series of novel , substituted 1-benzyl-5-phenyltetrazole P2X7 antagonists .
2122229	0	1-beta-D-arabinofuranosyl-cytosine	39,73	jun-B	14,19	1-beta-D-arabinofuranosyl-cytosine	jun-B	CHEBI:28680	3726	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of jun-B gene expression by 1-beta-D-arabinofuranosyl-cytosine in human myeloid_leukemia cells .
8732670	0	1-beta-D-arabinofuranosylcytosine	10,43	c-Jun	131,136	1-beta-D-arabinofuranosylcytosine	c-Jun	CHEBI:28680	3725	Chemical	Gene	cells|amod|START_ENTITY Effect|nmod|cells Effect|acl|expressing expressing|dobj|protein protein|amod|END_ENTITY	Effect of 1-beta-D-arabinofuranosylcytosine on apoptosis and differentiation in human monocytic_leukemia cells -LRB- U937 -RRB- expressing a c-Jun dominant-negative mutant protein -LRB- TAM67 -RRB- .
17213995	1	1-beta-D-arabinofuranosylcytosine	143,176	c-jun	84,89	1-beta-D-arabinofuranosylcytosine	c-jun	CHEBI:28680	3725	Chemical	Gene	KG-1|advcl|START_ENTITY line|xcomp|KG-1 line|nsubj|Induction Induction|nmod|expression expression|amod|END_ENTITY	Induction of c-jun expression in the myeloid_leukemia cell line KG-1 by 1-beta-D-arabinofuranosylcytosine .
1907849	0	1-beta-D-arabinofuranosylcytosine	63,96	c-jun	14,19	1-beta-D-arabinofuranosylcytosine	c-jun	CHEBI:28680	3725	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of c-jun gene expression in HL-60 leukemia cells by 1-beta-D-arabinofuranosylcytosine .
1996082	0	1-beta-D-arabinofuranosylcytosine	72,105	c-jun	13,18	1-beta-D-arabinofuranosylcytosine	c-jun	CHEBI:28680	3725	Chemical	Gene	KG-1|advcl|START_ENTITY line|xcomp|KG-1 line|nsubj|Induction Induction|nmod|expression expression|amod|END_ENTITY	Induction of c-jun expression in the myeloid_leukemia cell line KG-1 by 1-beta-D-arabinofuranosylcytosine .
1873797	0	1-beta-D-arabinofuranosylcytosine	59,92	cytidine_deaminase	153,171	1-beta-D-arabinofuranosylcytosine	cytidine deaminase	CHEBI:28680	978	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Hemin enhances the sensitivity of erythroleukemia cells to 1-beta-D-arabinofuranosylcytosine by both activation of deoxycytidine kinase and reduction of cytidine_deaminase activity .
2338846	0	1-beta-D-arabinofuranosylcytosine	28,61	cytidine_deaminase	82,100	1-beta-D-arabinofuranosylcytosine	cytidine deaminase	CHEBI:28680	978	Chemical	Gene	effect|nmod|START_ENTITY Modulation|nmod|effect based|nsubj|Modulation based|nmod|changes changes|nmod|activity activity|amod|END_ENTITY	Modulation of the effect of 1-beta-D-arabinofuranosylcytosine based on changes of cytidine_deaminase activity in HL60 cells .
19189864	0	1-bromopropane	11,25	BDNF	68,72	1-bromopropane	BDNF	MESH:C118559	12064(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of 1-bromopropane , a substitute for chlorofluorocarbons , on BDNF expression .
22466954	0	1-butanol	101,110	cyclic_AMP_receptor_protein	40,67	1-butanol	cyclic AMP receptor protein	MESH:D020001	20468888	Chemical	Gene	tolerance|amod|START_ENTITY END_ENTITY|nmod|tolerance	Engineering global transcription factor cyclic_AMP_receptor_protein of Escherichia_coli for improved 1-butanol tolerance .
16333570	0	1-butanol	56,65	phospholipase_D	28,43	1-butanol	phospholipase D	MESH:D020001	820816(Tax:3702)	Chemical	Gene	inhibitors|amod|START_ENTITY END_ENTITY|dobj|inhibitors	Differential effects of two phospholipase_D inhibitors , 1-butanol and N-acylethanolamine , on in vivo cytoskeletal organization and Arabidopsis seedling growth .
3918556	0	1-deamino_8_D-arginine_vasopressin	14,48	VIII	117,121	1-deamino 8 D-arginine vasopressin	VIII	MESH:D003894	1351	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nsubj|effect	The effect of 1-deamino_8_D-arginine_vasopressin -LRB- DDAVP -RRB- in a nonhaemophilic patient with an acquired type II factor VIII inhibitor .
19387866	0	1-deoxygalactonojirimycin	30,55	alpha-galactosidase_A	66,87	1-deoxygalactonojirimycin	alpha-galactosidase A	MESH:C483747|MESH:C090092	2717	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|amod|END_ENTITY	The pharmacological chaperone 1-deoxygalactonojirimycin increases alpha-galactosidase_A levels in Fabry patient cell lines .
14718372	0	1-deoxynojirimycin	49,67	glucosidase_I	105,118	1-deoxynojirimycin	glucosidase I	MESH:C478924|MESH:D017485	7841	Chemical	Gene	Synthesis|nmod|START_ENTITY Synthesis|nmod|END_ENTITY	Synthesis of a novel photoaffinity derivative of 1-deoxynojirimycin for active site-directed labeling of glucosidase_I .
15945653	0	1-ethyl-3-methylimidazolium_hexafluorophosphate	74,121	PF6	129,132	1-ethyl-3-methylimidazolium hexafluorophosphate	PF6	MESH:C518739	200162	Chemical	Gene	-RSB-|amod|START_ENTITY -RSB-|compound|END_ENTITY	Molecular dynamics studies of melting and some liquid-state properties of 1-ethyl-3-methylimidazolium_hexafluorophosphate -LSB- emim -RSB- -LSB- PF6 -RSB- .
24359159	0	1-methyl-1H-imidazole	13,34	Jak2	57,61	1-methyl-1H-imidazole	Jak2	CHEBI:113454	16452(Tax:10090)	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Discovery of 1-methyl-1H-imidazole derivatives as potent Jak2 inhibitors .
15978696	2	1-methyl-4-phenylpyridinium	330,357	PKCdelta	419,427	1-methyl-4-phenylpyridinium	PKCdelta	MESH:D015655	5580	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|nmod|END_ENTITY	Recently , we demonstrated that 1-methyl-4-phenylpyridinium -LRB- MPP + -RRB- induces caspase-3-dependent proteolytic activation of PKCdelta , which subsequently contributes to neuronal apoptotic cell death in mesencephalic dopaminergic neuronal cells .
23665112	0	1-methyl-4-phenylpyridinium	52,79	Secalonic_acid_A	0,16	1-methyl-4-phenylpyridinium	Secalonic acid A	MESH:D015655	6287	Chemical	Gene	protects|nmod|START_ENTITY protects|nsubj|END_ENTITY	Secalonic_acid_A protects dopaminergic neurons from 1-methyl-4-phenylpyridinium -LRB- MPP ___ -RRB- - induced cell death via the mitochondrial apoptotic pathway .
25483731	0	1-methylpropyl_2-imidazolyl_disulfide	25,62	Thioredoxin-1	0,13	1-methylpropyl 2-imidazolyl disulfide	Thioredoxin-1	MESH:C412893	7295	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Thioredoxin-1 inhibitor , 1-methylpropyl_2-imidazolyl_disulfide , inhibits the growth , migration and invasion of colorectal_cancer cell lines .
12657718	0	1-methylpropyl_2-imidazolyl_disulfide	33,70	thioredoxin	4,15	1-methylpropyl 2-imidazolyl disulfide	thioredoxin	MESH:C412893	7295	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	The thioredoxin redox inhibitors 1-methylpropyl_2-imidazolyl_disulfide and pleurotin inhibit hypoxia-induced factor 1alpha and vascular_endothelial_growth_factor formation .
3929786	0	1-naphthol	14,24	tyrosinase	28,38	1-naphthol	tyrosinase	MESH:C029350	7299	Chemical	Gene	Metabolism|nmod|START_ENTITY Metabolism|nmod|END_ENTITY	Metabolism of 1-naphthol by tyrosinase .
1479538	0	1-naphthol	113,123	uridine_diphosphate-glucuronyltransferase	46,87	1-naphthol	uridine diphosphate-glucuronyltransferase	MESH:C029350	24861(Tax:10116)	Chemical	Gene	activities|amod|START_ENTITY activities|amod|END_ENTITY	Species difference and tissue distribution of uridine_diphosphate-glucuronyltransferase activities toward E6080 , 1-naphthol and 4-hydroxybiphenyl .
24904980	0	1-nitropyrene	55,68	CXCL8	77,82	1-nitropyrene	CXCL8	MESH:C032668	3576	Chemical	Gene	responses|amod|START_ENTITY responses|compound|END_ENTITY	Calcium signaling and b2-adrenergic_receptors regulate 1-nitropyrene induced CXCL8 responses in BEAS-2B cells .
20209143	0	1-octanol	106,115	DOP-3	41,46	1-octanol	DOP-3	MESH:D020003	188499(Tax:6239)	Chemical	Gene	decreases|nmod|START_ENTITY decreases|nsubj|END_ENTITY	The C. _ elegans D2-like dopamine receptor DOP-3 decreases behavioral sensitivity to the olfactory stimulus 1-octanol .
2982664	0	1-oleoyl-2-acetylglycerol	74,99	E1_and_E2	15,24	1-oleoyl-2-acetylglycerol	E1 and E2	MESH:C038237	6080;26765	Chemical	Gene	enhance|nmod|START_ENTITY enhance|nsubj|END_ENTITY	Prostaglandins E1_and_E2 enhance the stimulation of superoxide release by 1-oleoyl-2-acetylglycerol from human neutrophils .
24634601	0	1-p-Coumaroyl_b-D-Glucoside	62,89	Akt	19,22	1-p-Coumaroyl b-D-Glucoside	Akt	null	11651(Tax:10090)	Chemical	Gene	Activity|nmod|START_ENTITY Activity|compound|END_ENTITY	Phosphorylation of Akt Mediates Anti-Inflammatory Activity of 1-p-Coumaroyl_b-D-Glucoside Against Lipopolysaccharide-Induced Inflammation in RAW264 .7 Cells .
6840488	0	1-phenylpentanol	10,26	secretin	41,49	1-phenylpentanol	secretin	null	483407(Tax:9615)	Chemical	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	Effect of 1-phenylpentanol on release of secretin and exocrine pancreatic secretion in dogs and humans .
4186	0	10-N-acylaminophenothiazine	21,48	SAS	10,13	10-N-acylaminophenothiazine	SAS	null	362890(Tax:10116)	Chemical	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of SAS -LRB- a new 10-N-acylaminophenothiazine -RRB- on gastric secretion and ulceration in rats .
10453996	0	10-Undecynoic_acid	0,18	cytochrome_P450_4A1	36,55	10-Undecynoic acid	cytochrome P450 4A1	MESH:C048289	50549(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	10-Undecynoic_acid , an inhibitor of cytochrome_P450_4A1 , inhibits ethanolamine-specific phospholipid base exchange reaction in rat liver microsomes .
26815184	0	10-hydroxycamptotbecine	11,34	VEGF	56,60	10-hydroxycamptotbecine	VEGF	null	7422	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of 10-hydroxycamptotbecine on the expression of VEGF in rheumatoid_arthritis synovial fibroblasts -RSB- .
21533497	0	10-hydroxycamptothecin	120,142	DNA_topoisomerase_I	89,108	10-hydroxycamptothecin	DNA topoisomerase I	MESH:C028098	21969(Tax:10090)	Chemical	Gene	inhibitors|xcomp|START_ENTITY inhibitors|nsubj|activity activity|nmod|administration administration|nmod|END_ENTITY	Antitumor activity and pharmacokinetics following oral administration of natural product DNA_topoisomerase_I inhibitors 10-hydroxycamptothecin and camptothecin in SCID mice bearing human breast_cancer xenografts .
8010056	0	10-hydroxycamptothecin	62,84	DNA_topoisomerase_I	86,105	10-hydroxycamptothecin	DNA topoisomerase I	MESH:C028098	21969(Tax:10090)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Inhibition of phosphorylation of histone H1 and H3 induced by 10-hydroxycamptothecin , DNA_topoisomerase_I inhibitor , in murine ascites hepatoma cells .
8239542	0	10-hydroxycamptothecin	41,63	DNA_topoisomerase_I	10,29	10-hydroxycamptothecin	DNA topoisomerase I	MESH:C028098	21969(Tax:10090)	Chemical	Gene	Effect|amod|START_ENTITY Effect|nmod|END_ENTITY	Effect of DNA_topoisomerase_I inhibitor , 10-hydroxycamptothecin , on the structure and function of nuclei and nuclear matrix in bladder_carcinoma MBT-2 cells .
17046567	0	10058-F4	34,42	c-Myc	17,22	10058-F4	c-Myc	null	4609	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	A small-molecule c-Myc inhibitor , 10058-F4 , induces cell-cycle arrest , apoptosis , and myeloid differentiation of human acute_myeloid_leukemia .
17159602	0	10058-F4	32,40	c-Myc	15,20	10058-F4	c-Myc	null	4609	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Small-molecule c-Myc inhibitor , 10058-F4 , inhibits proliferation , downregulates human telomerase_reverse_transcriptase and enhances chemosensitivity in human hepatocellular_carcinoma cells .
9683799	5	106_amino-acids	882,897	human	915,920	106 amino-acids	His 1	null	7435	Chemical	Gene	START_ENTITY|nmod|sequence sequence|amod|END_ENTITY	This clone shares 66 % overall homology to the carboxy-terminal 106_amino-acids of the published human sequence .
6181401	0	10S	28,31	acetylcholinesterase	32,52	10S	acetylcholinesterase	null	11423(Tax:10090)	Chemical	Gene	transport|nmod|START_ENTITY END_ENTITY|nsubj|transport	Reduced axonal transport of 10S acetylcholinesterase in dystrophic mice .
4050454	0	11-Deoxycortisol	0,16	tryptophan_oxygenase	33,53	11-Deoxycortisol	tryptophan oxygenase	MESH:D003350	64206(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	11-Deoxycortisol induces hepatic tryptophan_oxygenase in rats .
12852757	0	11-alkenylindenoisoquinoline	58,86	topoisomerase_I	87,102	11-alkenylindenoisoquinoline	topoisomerase I	null	7150	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Design , synthesis , and biological evaluation of cytotoxic 11-alkenylindenoisoquinoline topoisomerase_I inhibitors and indenoisoquinoline-camptothecin hybrids .
19458327	0	11-cis-retinol	4,18	RDH10	45,50	11-cis-retinol	RDH10	MESH:D014801	157506	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	The 11-cis-retinol dehydrogenase activity of RDH10 and its interaction with visual_cycle_proteins .
11418621	0	11-cis-retinol	74,88	RDH5	148,152	11-cis-retinol	RDH5	MESH:D014801	19682(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|epithelium epithelium|nmod|mice mice|nmod|gene gene|compound|END_ENTITY	Characterization of a dehydrogenase activity responsible for oxidation of 11-cis-retinol in the retinal pigment epithelium of mice with a disrupted RDH5 gene .
9931293	0	11-cis-retinol	18,32	Rdh5	48,52	11-cis-retinol	Rdh5	MESH:D014801	5959	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	Activity of human 11-cis-retinol dehydrogenase -LRB- Rdh5 -RRB- with steroids and retinoids and expression of its mRNA in extra-ocular human tissue .
23895845	0	11R-VIVIT	1,10	urokinase-type_plasminogen_activator_receptor	38,83	11R-VIVIT	urokinase-type plasminogen activator receptor	null	18793(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	-LSB- 11R-VIVIT inhibits the expression of urokinase-type_plasminogen_activator_receptor in podocytes -RSB- .
16234247	0	11_beta-hydroxysteroid	18,40	11_beta-HSD1	56,68	11 beta-hydroxysteroid	11 beta-HSD1	CHEBI:35346	25116(Tax:10116)	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|dep|END_ENTITY	Evidence that the 11_beta-hydroxysteroid dehydrogenase -LRB- 11_beta-HSD1 -RRB- is regulated by pentose pathway flux .
24729284	0	11b-hydroxysteroid	12,30	HSD11B	46,52	11b-hydroxysteroid	HSD11B	null	3290	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Variants of 11b-hydroxysteroid dehydrogenase -LRB- HSD11B -RRB- gene type 1 and 2 in Chinese obese adolescents .
18726827	0	11beta-hydroxysteroid	14,35	bombesin	64,72	11beta-hydroxysteroid	bombesin	CHEBI:35346	2922	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Modulation of 11beta-hydroxysteroid dehydrogenase expression by bombesin : a possible mechanism for glucocorticoid resistance in androgen_independent_prostate_cancer .
7849624	0	12-0-tetradecanoyl_phorbol-13-acetate	83,120	c-myc	34,39	12-0-tetradecanoyl phorbol-13-acetate	c-myc	null	4609	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of cell growth and the c-myc proto-oncogene expression by phorbol_ester 12-0-tetradecanoyl_phorbol-13-acetate -LRB- TPA -RRB- in the androgen-independent human prostatic JCA-1 cells .
26239613	0	12-Deoxyphorbol_13-palmitate	0,28	VEGF	56,60	12-Deoxyphorbol 13-palmitate	VEGF	null	7422	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	12-Deoxyphorbol_13-palmitate inhibits the expression of VEGF and HIF-1a in MCF-7 cells by blocking the PI3K/Akt/mTOR signaling pathway .
9016800	0	12-HETE	94,101	c-Jun_protein_kinase	21,41	12-HETE	c-Jun protein kinase	MESH:D019377	116554(Tax:10116)	Chemical	Gene	stimulated|nmod|START_ENTITY stimulated|nsubjpass|END_ENTITY	The stress-activated c-Jun_protein_kinase -LRB- JNK -RRB- is stimulated by lipoxygenase pathway product 12-HETE in RIN_m5F cells .
24753817	0	12-O-Tetradecanoylphorbol-13-Acetate	0,36	Keratin_8	45,54	12-O-Tetradecanoylphorbol-13-Acetate	Keratin 8	MESH:C554292|MESH:D013755	3856	Chemical	Gene	Phosphorylation|amod|START_ENTITY Phosphorylation|compound|END_ENTITY	12-O-Tetradecanoylphorbol-13-Acetate Induces Keratin_8 Phosphorylation and Reorganization via Expression of Transglutaminase-2 .
24753817	0	12-O-Tetradecanoylphorbol-13-Acetate	0,36	Transglutaminase-2	108,126	12-O-Tetradecanoylphorbol-13-Acetate	Transglutaminase-2	MESH:C554292|MESH:D013755	7052	Chemical	Gene	Phosphorylation|amod|START_ENTITY Phosphorylation|nmod|END_ENTITY	12-O-Tetradecanoylphorbol-13-Acetate Induces Keratin_8 Phosphorylation and Reorganization via Expression of Transglutaminase-2 .
11675357	3	12-O-tetradecanoyl-phorbol-13-acetate	679,716	cytochrome_c	813,825	12-O-tetradecanoyl-phorbol-13-acetate	cytochrome c	MESH:C554292|MESH:D013755	54205	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|amod|END_ENTITY	Furthermore , the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate , which stimulates sphingosine kinase , the enzyme responsible for S-1P production , also inhibits cytochrome_c and Smac/DIABLO release .
10406459	0	12-O-tetradecanoyl-phorbol_acetate	54,88	CREB	133,137	12-O-tetradecanoyl-phorbol acetate	CREB	null	12912(Tax:10090)	Chemical	Gene	activation|amod|START_ENTITY activation|compound|END_ENTITY	A dominant role for the Raf-MEK pathway in forskolin , 12-O-tetradecanoyl-phorbol_acetate , and platelet-derived growth factor-induced CREB -LRB- cAMP-responsive_element-binding_protein -RRB- activation , uncoupled from serine 133 phosphorylation in NIH 3T3 cells .
2981678	0	12-O-tetradecanoyl_phorbol-13-acetate	0,37	GH	69,71	12-O-tetradecanoyl phorbol-13-acetate	GH	MESH:C554292|MESH:D013755	81668(Tax:10116)	Chemical	Gene	growth_hormone|amod|START_ENTITY growth_hormone|appos|END_ENTITY	12-O-tetradecanoyl_phorbol-13-acetate stimulates rat growth_hormone -LRB- GH -RRB- release through different pathways from that of human pancreatic GH-releasing factor .
2370555	0	12-O-tetradecanoyl_phorbol_13-acetate	52,89	nerve_growth_factor	13,32	12-O-tetradecanoyl phorbol 13-acetate	nerve growth factor	MESH:C554292|MESH:D013755	18049(Tax:10090)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|expression expression|compound|END_ENTITY	Induction of nerve_growth_factor gene expression by 12-O-tetradecanoyl_phorbol_13-acetate .
1642085	0	12-O-tetradecanoyl_phorbol_13-acetate	187,224	parathyroid_hormone	14,33	12-O-tetradecanoyl phorbol 13-acetate	parathyroid hormone	MESH:C554292|MESH:D013755	5741	Chemical	Gene	release|nmod|START_ENTITY release|amod|END_ENTITY	Regulation of parathyroid_hormone release in normal and pathological parathyroid cells exposed to modulators of protein kinase C. Effects of the protein kinase C activating phorbol_ester 12-O-tetradecanoyl_phorbol_13-acetate and the inhibitor 1 - -LRB- 5-isoquinolinyl-sulfonyl -RRB- -2 - methylpiperazine -LRB- H-7 -RRB- on parathyroid_hormone -LRB- PTH -RRB- release were studied in normal bovine and pathological human parathyroid cells .
9600114	0	12-O-tetradecanoylphorbol-13-acetate	0,36	CD30	71,75	12-O-tetradecanoylphorbol-13-acetate	CD30	MESH:C554292|MESH:D013755	943	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|nmod|END_ENTITY	12-O-tetradecanoylphorbol-13-acetate -LRB- TPA -RRB- downregulates expression of CD30 in erythroleukemia cell line K562 .
1698561	0	12-O-tetradecanoylphorbol-13-acetate	51,87	CD5	25,28	12-O-tetradecanoylphorbol-13-acetate	CD5	MESH:C554292|MESH:D013755	921	Chemical	Gene	modulation|nmod|START_ENTITY modulation|compound|END_ENTITY	Quantitative analysis of CD5 antigen modulation by 12-O-tetradecanoylphorbol-13-acetate in T-lymphoblastic_leukemia cells : individual response patterns and their relationships with both maturation and protein kinase C content .
16332726	0	12-O-tetradecanoylphorbol-13-acetate	37,73	CEACAM1	15,22	12-O-tetradecanoylphorbol-13-acetate	CEACAM1	MESH:C554292|MESH:D013755	634	Chemical	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Stimulation of CEACAM1 expression by 12-O-tetradecanoylphorbol-13-acetate -LRB- TPA -RRB- and calcium ionophore A23187 in endometrial_carcinoma cells .
498078	0	12-O-tetradecanoylphorbol-13-acetate	92,128	Ornithine_decarboxylase	0,23	12-O-tetradecanoylphorbol-13-acetate	Ornithine decarboxylase	MESH:C554292|MESH:D013755	4953	Chemical	Gene	culture|nmod|START_ENTITY cells|nmod|culture treatment|nmod|cells END_ENTITY|nmod|treatment	Ornithine_decarboxylase activity and DNA synthesis after treatment of cells in culture with 12-O-tetradecanoylphorbol-13-acetate .
20308057	0	12-O-tetradecanoylphorbol-13-acetate	62,98	RasGRP1	0,7	12-O-tetradecanoylphorbol-13-acetate	RasGRP1	MESH:C554292|MESH:D013755	19419(Tax:10090)	Chemical	Gene	essential|nmod|START_ENTITY essential|nsubj|END_ENTITY	RasGRP1 is essential for ras activation by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate in epidermal keratinocytes .
12917633	0	12-O-tetradecanoylphorbol-13-acetate	91,127	WAF-1	70,75	12-O-tetradecanoylphorbol-13-acetate	WAF-1	MESH:C554292|MESH:D013755	1026	Chemical	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Role of protein kinase C and the Sp1-p53 complex in activation of p21 -LRB- WAF-1 -RRB- expression by 12-O-tetradecanoylphorbol-13-acetate in human T cells .
22299029	0	12-O-tetradecanoylphorbol-13-acetate	67,103	c-Jun	33,38	12-O-tetradecanoylphorbol-13-acetate	c-Jun	MESH:C554292|MESH:D013755	3725	Chemical	Gene	activation|nmod|START_ENTITY activation|nsubj|role role|nmod|END_ENTITY	Differential role of PKC-induced c-Jun in HTLV-1 LTR activation by 12-O-tetradecanoylphorbol-13-acetate in different human T-cell lines .
3383343	0	12-O-tetradecanoylphorbol-13-acetate	47,83	catalase	16,24	12-O-tetradecanoylphorbol-13-acetate	catalase	MESH:C554292|MESH:D013755	12359(Tax:10090)	Chemical	Gene	Distribution|nmod|START_ENTITY Distribution|nmod|END_ENTITY	Distribution of catalase and its modulation by 12-O-tetradecanoylphorbol-13-acetate in murine dermis and subpopulations of keratinocytes differing in their stages of differentiation .
7907090	0	12-O-tetradecanoylphorbol-13-acetate	0,36	intercellular_adhesion_molecule-1	92,125	12-O-tetradecanoylphorbol-13-acetate	intercellular adhesion molecule-1	MESH:C554292|MESH:D013755	3383	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	12-O-tetradecanoylphorbol-13-acetate - and tumor_necrosis_factor_alpha-mediated induction of intercellular_adhesion_molecule-1 is inhibited by dexamethasone .
1715761	0	12-O-tetradecanoylphorbol-13-acetate	74,110	interleukin-2	23,36	12-O-tetradecanoylphorbol-13-acetate	interleukin-2	MESH:C554292|MESH:D013755	3558	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|production production|compound|END_ENTITY	Negative regulation of interleukin-2 production in primary lymphocytes by 12-O-tetradecanoylphorbol-13-acetate .
9254882	0	12-O-tetradecanoylphorbol-13-acetate	10,46	keratin_1	78,87	12-O-tetradecanoylphorbol-13-acetate	keratin 1	MESH:C554292|MESH:D013755	16678(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|mRNA mRNA|amod|END_ENTITY	Effect of 12-O-tetradecanoylphorbol-13-acetate on inhibition of expression of keratin_1 mRNA in mouse keratinocytes mimicked by 12 -LRB- S -RRB- - hydroxyeicosatetraenoic_acid .
3023307	0	12-O-tetradecanoylphorbol-13-acetate	68,104	myeloperoxidase	14,29	12-O-tetradecanoylphorbol-13-acetate	myeloperoxidase	MESH:C554292|MESH:D013755	4353	Chemical	Gene	Regulation|amod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of myeloperoxidase gene expression by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate in human leukemia HL-60 cells .
10903418	0	12-O-tetradecanoylphorbol-13-acetate	14,50	ornithine_decarboxylase	76,99	12-O-tetradecanoylphorbol-13-acetate	ornithine decarboxylase	MESH:C554292|MESH:D013755	18263(Tax:10090)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|acl|induced induced|dobj|END_ENTITY	Inhibition of 12-O-tetradecanoylphorbol-13-acetate -LRB- TPA -RRB- - induced mouse skin ornithine_decarboxylase and protein kinase C by polyphenolics from grapes .
2369749	0	12-O-tetradecanoylphorbol-13-acetate	141,177	ornithine_decarboxylase	63,86	12-O-tetradecanoylphorbol-13-acetate	ornithine decarboxylase	MESH:C554292|MESH:D013755	18263(Tax:10090)	Chemical	Gene	epidermis|nmod|START_ENTITY treatment|nmod|epidermis activity|nmod|treatment activity|amod|END_ENTITY	Identification of epidermal cell subpopulations with increased ornithine_decarboxylase activity following treatment of murine epidermis with 12-O-tetradecanoylphorbol-13-acetate .
2642750	0	12-O-tetradecanoylphorbol-13-acetate	132,168	ornithine_decarboxylase	14,37	12-O-tetradecanoylphorbol-13-acetate	ornithine decarboxylase	MESH:C554292|MESH:D013755	4953	Chemical	Gene	fibroblasts|advcl|START_ENTITY fibroblasts|nsubj|Regulation Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of ornithine_decarboxylase gene expression in normal and transformed hamster embryo fibroblasts following stimulation by 12-O-tetradecanoylphorbol-13-acetate .
2912589	0	12-O-tetradecanoylphorbol-13-acetate	67,103	ornithine_decarboxylase	31,54	12-O-tetradecanoylphorbol-13-acetate	ornithine decarboxylase	MESH:C554292|MESH:D013755	18263(Tax:10090)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|induction induction|nmod|activity activity|amod|END_ENTITY	Inhibition of the induction of ornithine_decarboxylase activity by 12-O-tetradecanoylphorbol-13-acetate in mouse skin by sphingosine_sulfate .
3081271	0	12-O-tetradecanoylphorbol-13-acetate	101,137	ornithine_decarboxylase	74,97	12-O-tetradecanoylphorbol-13-acetate	ornithine decarboxylase	MESH:C554292|MESH:D013755	18263(Tax:10090)	Chemical	Gene	tissues|amod|START_ENTITY inhibitors|nmod|tissues inhibitors|nmod|induction induction|nmod|END_ENTITY	Effects of lipoxygenase and cyclooxygenase inhibitors on the induction of ornithine_decarboxylase by 12-O-tetradecanoylphorbol-13-acetate and isoproterenol in mouse tissues in vivo .
3125055	0	12-O-tetradecanoylphorbol-13-acetate	51,87	ornithine_decarboxylase	17,40	12-O-tetradecanoylphorbol-13-acetate	ornithine decarboxylase	MESH:C554292|MESH:D013755	18263(Tax:10090)	Chemical	Gene	caused|nmod|START_ENTITY END_ENTITY|acl|caused	The induction of ornithine_decarboxylase caused by 12-O-tetradecanoylphorbol-13-acetate in isolated epidermal cells is inhibited by lipoxygenase inhibitors but not by cyclooxygenase inhibitors .
3355171	0	12-O-tetradecanoylphorbol-13-acetate	112,148	ornithine_decarboxylase	69,92	12-O-tetradecanoylphorbol-13-acetate	ornithine decarboxylase	MESH:C554292|MESH:D013755	4953	Chemical	Gene	cells|amod|START_ENTITY kinase|nmod|cells kinase|dobj|C C|nmod|regulation regulation|nmod|expression expression|amod|END_ENTITY	Involvement of protein kinase C in the transcriptional regulation of ornithine_decarboxylase gene expression by 12-O-tetradecanoylphorbol-13-acetate in T24 human bladder_carcinoma cells .
3632701	0	12-O-tetradecanoylphorbol-13-acetate	87,123	ornithine_decarboxylase	23,46	12-O-tetradecanoylphorbol-13-acetate	ornithine decarboxylase	MESH:C554292|MESH:D013755	24609(Tax:10116)	Chemical	Gene	treated|advcl|START_ENTITY treated|nsubj|induction induction|nmod|mRNA mRNA|amod|END_ENTITY	Transient induction of ornithine_decarboxylase mRNA in rat hepatoma cells treated with 12-O-tetradecanoylphorbol-13-acetate .
3664957	0	12-O-tetradecanoylphorbol-13-acetate	26,62	ornithine_decarboxylase	88,111	12-O-tetradecanoylphorbol-13-acetate	ornithine decarboxylase	MESH:C554292|MESH:D013755	18263(Tax:10090)	Chemical	Gene	butyric_acid|nmod|START_ENTITY Effect|nmod|butyric_acid Effect|dep|TPA TPA|acl|induced induced|dobj|END_ENTITY	Effect of butyric_acid on 12-O-tetradecanoylphorbol-13-acetate - -LRB- TPA -RRB- induced mouse skin ornithine_decarboxylase -LRB- ODC -RRB- .
3779635	0	12-O-tetradecanoylphorbol-13-acetate	169,205	ornithine_decarboxylase	46,69	12-O-tetradecanoylphorbol-13-acetate	ornithine decarboxylase	MESH:C554292|MESH:D013755	18263(Tax:10090)	Chemical	Gene	kinase|advcl|START_ENTITY kinase|nmod|expression expression|amod|END_ENTITY	Involvement of protein kinase C activation in ornithine_decarboxylase gene expression in primary culture of newborn mouse epidermal cells and in skin_tumor promotion by 12-O-tetradecanoylphorbol-13-acetate .
3940182	0	12-O-tetradecanoylphorbol-13-acetate	85,121	ornithine_decarboxylase	48,71	12-O-tetradecanoylphorbol-13-acetate	ornithine decarboxylase	MESH:C554292|MESH:D013755	18263(Tax:10090)	Chemical	Gene	promoter-induced|nmod|START_ENTITY promoter-induced|nmod|induction induction|amod|END_ENTITY	Tumor promoter-induced refractory state against ornithine_decarboxylase induction by 12-O-tetradecanoylphorbol-13-acetate in mouse epidermis .
4066760	0	12-O-tetradecanoylphorbol-13-acetate	125,161	ornithine_decarboxylase	98,121	12-O-tetradecanoylphorbol-13-acetate	ornithine decarboxylase	MESH:C554292|MESH:D013755	4953	Chemical	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	Phorbol_esters and gene expression : the role of rapid changes in K + transport in the induction of ornithine_decarboxylase by 12-O-tetradecanoylphorbol-13-acetate in BALB/c 3T3 cells and a mutant cell line defective in Na + K+C l - cotransport .
4075283	0	12-O-tetradecanoylphorbol-13-acetate	44,80	ornithine_decarboxylase	133,156	12-O-tetradecanoylphorbol-13-acetate	ornithine decarboxylase	MESH:C554292|MESH:D013755	18263(Tax:10090)	Chemical	Gene	induction|amod|START_ENTITY induction|dep|END_ENTITY	Enhancement by adriamycin of the effects of 12-O-tetradecanoylphorbol-13-acetate on mouse epidermal glutathione peroxidase activity , ornithine_decarboxylase induction and skin_tumor promotion .
6697440	0	12-O-tetradecanoylphorbol-13-acetate	94,130	ornithine_decarboxylase	42,65	12-O-tetradecanoylphorbol-13-acetate	ornithine decarboxylase	MESH:C554292|MESH:D013755	24609(Tax:10116)	Chemical	Gene	promoters|amod|START_ENTITY activity|nmod|promoters activity|amod|END_ENTITY	Relation between induction of rat hepatic ornithine_decarboxylase activity by tumor promoters 12-O-tetradecanoylphorbol-13-acetate and phenobarbital and levels of the polyamines_putrescine , spermidine and spermine , in vivo ; differential effects of retinyl-acetate .
6850576	0	12-O-tetradecanoylphorbol-13-acetate	127,163	ornithine_decarboxylase	83,106	12-O-tetradecanoylphorbol-13-acetate	ornithine decarboxylase	MESH:C554292|MESH:D013755	18263(Tax:10090)	Chemical	Gene	induced|advcl|START_ENTITY activity|acl|induced activity|compound|END_ENTITY	Inhibition by 2 -LRB- 3 -RRB- - tert-butyl-4-hydroxyanisole and other antioxidants of epidermal ornithine_decarboxylase activity induced by 12-O-tetradecanoylphorbol-13-acetate .
7116338	0	12-O-tetradecanoylphorbol-13-acetate	16,52	ornithine_decarboxylase	99,122	12-O-tetradecanoylphorbol-13-acetate	ornithine decarboxylase	MESH:C554292|MESH:D013755	18263(Tax:10090)	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|activities activities|amod|END_ENTITY	Dissociation of 12-O-tetradecanoylphorbol-13-acetate and 3-methylcholanthrene-induced induction in ornithine_decarboxylase and aryl_hydrocarbon_hydroxylase activities in C57BL/6 mouse dermal fibroblasts in culture .
7251684	0	12-O-tetradecanoylphorbol-13-acetate	19,55	ornithine_decarboxylase	64,87	12-O-tetradecanoylphorbol-13-acetate	ornithine decarboxylase	MESH:C554292|MESH:D013755	18263(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	The tumor promoter 12-O-tetradecanoylphorbol-13-acetate induces ornithine_decarboxylase in proliferating basal cells but not in differentiating cells from mouse epidermis .
7326828	0	12-O-tetradecanoylphorbol-13-acetate	72,108	ornithine_decarboxylase	25,48	12-O-tetradecanoylphorbol-13-acetate	ornithine decarboxylase	MESH:C554292|MESH:D013755	24609(Tax:10116)	Chemical	Gene	promotors|amod|START_ENTITY END_ENTITY|nmod|promotors	Induction of rat hepatic ornithine_decarboxylase by the tumor promotors 12-O-tetradecanoylphorbol-13-acetate and phenobarbital in vivo ; effect of retinyl-acetate .
7448775	0	12-O-tetradecanoylphorbol-13-acetate	78,114	ornithine_decarboxylase	41,64	12-O-tetradecanoylphorbol-13-acetate	ornithine decarboxylase	MESH:C554292|MESH:D013755	18263(Tax:10090)	Chemical	Gene	retinoic_acid|nmod|START_ENTITY retinoic_acid|dobj|inhibition inhibition|nmod|induction induction|amod|END_ENTITY	Differential retinoic_acid inhibition of ornithine_decarboxylase induction by 12-O-tetradecanoylphorbol-13-acetate and by germicidal ultraviolet light .
7651380	0	12-O-tetradecanoylphorbol-13-acetate	8,44	ornithine_decarboxylase	63,86	12-O-tetradecanoylphorbol-13-acetate	ornithine decarboxylase	MESH:C554292|MESH:D013755	4953	Chemical	Gene	responsiveness|amod|START_ENTITY responsiveness|nmod|introns introns|amod|END_ENTITY	Lack of 12-O-tetradecanoylphorbol-13-acetate responsiveness of ornithine_decarboxylase introns which have AP-1 consensus sequences .
8890958	0	12-O-tetradecanoylphorbol-13-acetate	20,56	ornithine_decarboxylase	79,102	12-O-tetradecanoylphorbol-13-acetate	ornithine decarboxylase	MESH:C554292|MESH:D013755	4953	Chemical	Gene	response|amod|START_ENTITY response|nmod|promoter promoter|compound|END_ENTITY	Localization of the 12-O-tetradecanoylphorbol-13-acetate response of the human ornithine_decarboxylase promoter to the TATA box .
12917633	0	12-O-tetradecanoylphorbol-13-acetate	91,127	p21	66,69	12-O-tetradecanoylphorbol-13-acetate	p21	MESH:C554292|MESH:D013755	1026	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Role of protein kinase C and the Sp1-p53 complex in activation of p21 -LRB- WAF-1 -RRB- expression by 12-O-tetradecanoylphorbol-13-acetate in human T cells .
17652337	0	12-O-tetradecanoylphorbol-13-acetate	20,56	sod2	67,71	12-O-tetradecanoylphorbol-13-acetate	sod2	MESH:C554292|MESH:D013755	20656(Tax:10090)	Chemical	Gene	induction|amod|START_ENTITY induction|amod|END_ENTITY	Chronic exposure to 12-O-tetradecanoylphorbol-13-acetate represses sod2 induction in vivo : the negative role of p50 .
2522003	0	12-O-tetradecanoylphorbol-13-acetate	99,135	thromboxane_A2_receptor	14,37	12-O-tetradecanoylphorbol-13-acetate	thromboxane A2 receptor	MESH:C554292|MESH:D013755	6915	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of thromboxane_A2_receptor in cultured human erythroleukemia cells and its induction by 12-O-tetradecanoylphorbol-13-acetate .
1356818	0	12-O-tetradecanoylphorbol-13-acetate	52,88	transglutaminase_1	14,32	12-O-tetradecanoylphorbol-13-acetate	transglutaminase 1	MESH:C554292|MESH:D013755	7051	Chemical	Gene	Regulation|acl|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of transglutaminase_1 gene expression by 12-O-tetradecanoylphorbol-13-acetate , dexamethasone , and retinoic_acid in cultured human keratinocytes .
10978519	0	12-O-tetradecanoylphorbol-13-acetate	81,117	vimentin	121,129	12-O-tetradecanoylphorbol-13-acetate	vimentin	MESH:C554292|MESH:D013755	22352(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Similar effects of electroporational stress and treatment with the phorbol_ester 12-O-tetradecanoylphorbol-13-acetate on vimentin expression in mouse_plasmacytoma cells .
17379955	0	12-O-tetradecanoylphorbol_13-acetate	127,163	Lck	108,111	12-O-tetradecanoylphorbol 13-acetate	Lck	MESH:C554292|MESH:D013755	3932	Chemical	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	Geldanamycin , a heat-shock_protein_90-binding agent , induces thymocyte apoptosis through destabilization of Lck in presence of 12-O-tetradecanoylphorbol_13-acetate .
2722855	0	12-O-tetradecanoylphorbol_13-acetate	85,121	Osteopontin	0,11	12-O-tetradecanoylphorbol 13-acetate	Osteopontin	MESH:C554292|MESH:D013755	6696	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Osteopontin , a transformation-associated cell adhesion phosphoprotein , is induced by 12-O-tetradecanoylphorbol_13-acetate in mouse epidermis .
2996613	0	12-O-tetradecanoylphorbol_13-acetate	98,134	Ribosomal_protein_S6	0,20	12-O-tetradecanoylphorbol 13-acetate	Ribosomal protein S6	MESH:C554292|MESH:D013755	6194	Chemical	Gene	changes|amod|START_ENTITY changes|amod|END_ENTITY	Ribosomal_protein_S6 phosphorylation and morphological changes in response to the tumour promoter 12-O-tetradecanoylphorbol_13-acetate in primary human tumour cells , established and transformed cell lines .
12444985	0	12-O-tetradecanoylphorbol_13-acetate	62,98	presenilin_1	41,53	12-O-tetradecanoylphorbol 13-acetate	presenilin 1	MESH:C554292|MESH:D013755	5663	Chemical	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Activation of transcription of the human presenilin_1 gene by 12-O-tetradecanoylphorbol_13-acetate .
7533733	0	12-hydroxyeicosatetraenoic_acid	18,49	Renin	0,5	12-hydroxyeicosatetraenoic acid	Renin	null	24715(Tax:10116)	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Renin response to 12-hydroxyeicosatetraenoic_acid is increased in diabetic rats .
3149510	0	12-iodo-cis-9-octadecenoic_acid	42,73	lipoxygenase_1	24,38	12-iodo-cis-9-octadecenoic acid	lipoxygenase 1	null	547923(Tax:3847)	Chemical	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of soybean lipoxygenase_1 by 12-iodo-cis-9-octadecenoic_acid .
11197217	3	12-o-tetradecanoyl_phorbol-13-acetate	661,698	Bfl-1	650,655	12-o-tetradecanoyl phorbol-13-acetate	Bfl-1	MESH:C554292|MESH:D013755	597	Chemical	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Either induced expression of Bfl-1 with 12-o-tetradecanoyl_phorbol-13-acetate or exogenous expression of Bfl-1 by transfection in Reh cells promoted cell survival .
3345508	0	12-o-tetradecanoylphorbol-13-acetate	117,153	ornithine_decarboxylase	13,36	12-o-tetradecanoylphorbol-13-acetate	ornithine decarboxylase	MESH:C554292|MESH:D013755	24609(Tax:10116)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|activities activities|amod|END_ENTITY	Induction of ornithine_decarboxylase and histidine_decarboxylase activities in rat colon mucosa after application of 12-o-tetradecanoylphorbol-13-acetate -LRB- TPA -RRB- , sodium_deoxycholate and indole .
8700159	0	12-o-tetradecanoylphorbol-13-acetate	79,115	ornithine_decarboxylase	34,57	12-o-tetradecanoylphorbol-13-acetate	ornithine decarboxylase	MESH:C554292|MESH:D013755	18263(Tax:10090)	Chemical	Gene	treatments|amod|START_ENTITY epidermal|nmod|treatments epidermal|dobj|activity activity|amod|END_ENTITY	Superinduction of mouse epidermal ornithine_decarboxylase activity by repeated 12-o-tetradecanoylphorbol-13-acetate treatments .
8993955	0	12-o-tetradecanoylphorbol-13-acetate	96,132	ornithine_decarboxylase	37,60	12-o-tetradecanoylphorbol-13-acetate	ornithine decarboxylase	MESH:C554292|MESH:D013755	18263(Tax:10090)	Chemical	Gene	evoked|nmod|START_ENTITY evoked|nsubj|effect effect|nmod|A A|nmod|induction induction|amod|END_ENTITY	Enhancing effect of ultraviolet A on ornithine_decarboxylase induction and dermatitis evoked by 12-o-tetradecanoylphorbol-13-acetate and its inhibition by curcumin in mouse skin .
9021107	0	123I-5-I-R91150	22,37	5-HT2A	51,57	123I-5-I-R91150	5-HT2A	MESH:C504893	3356	Chemical	Gene	evaluation|nmod|START_ENTITY evaluation|appos|END_ENTITY	Initial evaluation of 123I-5-I-R91150 , a selective 5-HT2A ligand for single-photon emission tomography , in healthy human subjects .
2993293	2	125I-azidobenzoyl-ANF	297,318	ANF	292,295	125I-azidobenzoyl-ANF	ANF	null	100009087(Tax:9986)	Chemical	Gene	analog|amod|START_ENTITY analog|nmod|END_ENTITY	In the first , the photoreactive analog of ANF , 125I-azidobenzoyl-ANF , was synthesized and used to photoaffinity label ANF receptors .
6583687	0	12S-hydroxyicosatetraenoic_acid	86,117	thrombin	130,138	12S-hydroxyicosatetraenoic acid	thrombin	null	2147	Chemical	Gene	START_ENTITY|acl|produced produced|nmod|END_ENTITY	12S,20-dihydroxyicosatetraenoic _ acid : a new icosanoid synthesized by neutrophils from 12S-hydroxyicosatetraenoic_acid produced by thrombin - or collagen-stimulated platelets .
7298161	0	13-Hydroperoxylinoleic_acid	0,27	glyoxalase_II	47,60	13-Hydroperoxylinoleic acid	glyoxalase II	MESH:C032890	24439(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	13-Hydroperoxylinoleic_acid inhibits rat liver glyoxalase_II .
2064786	1	13-cis-Retinoic_acid	92,112	thioredoxin_reductase	154,175	13-cis-Retinoic acid	thioredoxin reductase	MESH:D015474	25824	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	13-cis-Retinoic_acid is a stereospecific suicide inhibitor of thioredoxin_reductase .
24858462	0	13-cis-retinoic_acid	22,42	BCL-2	57,62	13-cis-retinoic acid	BCL-2	MESH:D015474	596	Chemical	Gene	modulation|amod|START_ENTITY modulation|nmod|END_ENTITY	Interferon alpha plus 13-cis-retinoic_acid modulation of BCL-2 plus paclitaxel for recurrent small-cell_lung_cancer -LRB- SCLC -RRB- : an Eastern Cooperative Oncology Group study -LRB- E6501 -RRB- .
21159604	0	13-cis-retinoic_acid	68,88	Bcl-2	122,127	13-cis-retinoic acid	Bcl-2	MESH:D015474	596	Chemical	Gene	lines|nmod|START_ENTITY chemotherapy|nmod|lines Antagonism|nmod|chemotherapy mediated|nsubjpass|Antagonism mediated|nmod|proteins proteins|compound|END_ENTITY	Antagonism of cytotoxic chemotherapy in neuroblastoma cell lines by 13-cis-retinoic_acid is mediated by the antiapoptotic Bcl-2 family proteins .
12646198	0	13-cis-retinoic_acid	0,20	RoDH-4	102,108	13-cis-retinoic acid	RoDH-4	MESH:D015474	8608	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	13-cis-retinoic_acid competitively inhibits 3 alpha-hydroxysteroid oxidation by retinol dehydrogenase RoDH-4 : a mechanism for its anti-androgenic effects in sebaceous glands ?
10621853	0	13-cis-retinoic_acid	41,61	bcl-2	0,5	13-cis-retinoic acid	bcl-2	MESH:D015474	596	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	bcl-2 expression and apoptotic bodies in 13-cis-retinoic_acid -LRB- isotretinoin -RRB- - topically treated oral_leukoplakia : a pilot study .
18652567	0	13-cis-retinoic_acid	0,20	caspase-3	53,62	13-cis-retinoic acid	caspase-3	MESH:D015474	12367(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|modulating modulating|dobj|END_ENTITY	13-cis-retinoic_acid induces apoptosis by modulating caspase-3 , bcl-2 , and p53 gene expression and regulates the activation of transcription factors in B16F-10 melanoma cells .
22571649	0	13-cis-retinoic_acid	131,151	erythropoietin	114,128	13-cis-retinoic acid	erythropoietin	MESH:D015474	2056	Chemical	Gene	+|amod|START_ENTITY +|compound|END_ENTITY	Long-term follow-up of myelodysplastic_syndrome patients with moderate/severe anaemia receiving human recombinant erythropoietin + 13-cis-retinoic_acid and dihydroxylated_vitamin_D3 : independent positive impact of erythroid response on survival .
9680102	0	13-cis-retinoic_acid	17,37	erythropoietin	82,96	13-cis-retinoic acid	erythropoietin	MESH:D015474	2056	Chemical	Gene	trial|nmod|START_ENTITY trial|nmod|END_ENTITY	A pilot trial of 13-cis-retinoic_acid and alpha-tocopherol with recombinant human erythropoietin in myelodysplastic_syndrome patients with progressive or transfusion-dependent anemias .
11051228	0	13-cis-retinoic_acid	10,30	prostate-specific_antigen	40,65	13-cis-retinoic acid	prostate-specific antigen	MESH:D015474	354	Chemical	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Effect of 13-cis-retinoic_acid on serum prostate-specific_antigen levels in patients with recurrent prostate_cancer after radical prostatectomy .
9815590	0	13-cis-retinoic_acid	10,30	prostate-specific_antigen	112,137	13-cis-retinoic acid	prostate-specific antigen	MESH:D015474	354	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of 13-cis-retinoic_acid and alpha-interferon on transforming_growth_factor_beta1 in patients with rising prostate-specific_antigen .
9815590	0	13-cis-retinoic_acid	10,30	transforming_growth_factor_beta1	55,87	13-cis-retinoic acid	transforming growth factor beta1	MESH:D015474	7040	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of 13-cis-retinoic_acid and alpha-interferon on transforming_growth_factor_beta1 in patients with rising prostate-specific_antigen .
955568	0	13-leucine	106,116	motilin	117,124	13-leucine	motilin	null	4295	Chemical	Gene	-RSB-|amod|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- The synthesis of motilin , I : Preparation of the sequence fragments 9 - 22 of -LSB- 13-norleucine -RSB- motilin and -LSB- 13-leucine -RSB- motilin -LRB- author 's transl -RRB- -RSB- .
1799584	0	13C	29,32	CO2	44,47	13C	CO2	CHEBI:36928	717	Chemical	Gene	analysis|nmod|START_ENTITY analysis|nmod|END_ENTITY	Rapid , automated analysis of 13C and 18O of CO2 in gas samples by continuous-flow , isotope ratio mass spectrometry .
20663293	0	1400W	24,29	Inducible_NOS	0,13	1400W	Inducible NOS	MESH:C496401	24599(Tax:10116)	Chemical	Gene	inhibitor|nummod|START_ENTITY inhibitor|compound|END_ENTITY	Inducible_NOS inhibitor 1400W reduces hypoxia/re-oxygenation injury in rat lung .
11761338	0	1400W	29,34	NOS2	13,17	1400W	NOS2	MESH:C496401	4843	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	The specific NOS2 inhibitor , 1400W , sensitizes HepG2 cells to genotoxic , oxidative , xenobiotic , and endoplasmic reticulum stresses .
14744612	0	1400W	47,52	iNOS	67,71	1400W	iNOS	MESH:C496401	24599(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Increased vasoconstriction to noradrenaline by 1400W , inhibitor of iNOS , in rats with streptozotocin-induced diabetes .
15880470	0	1400W	86,91	iNOS	71,75	1400W	iNOS	MESH:C496401	24599(Tax:10116)	Chemical	Gene	further|nmod:npmod|START_ENTITY improves|advmod|further improves|nsubj|Addition Addition|nmod|S-nitroso-N-acetylcysteine S-nitroso-N-acetylcysteine|nmod|inhibitor inhibitor|compound|END_ENTITY	Addition of nitric_oxide donor S-nitroso-N-acetylcysteine to selective iNOS inhibitor 1400W further improves contractile function in reperfused skeletal muscle .
18565249	0	1400W	25,30	iNOS	10,14	1400W	iNOS	MESH:C496401	51477	Chemical	Gene	inhibitor|dep|START_ENTITY END_ENTITY|amod|inhibitor	Selective iNOS inhibitor 1400W enhances anti-catabolic IL-10 and reduces destructive MMP-10 in OA cartilage .
18791203	7	1400W	1529,1534	iNOS	1514,1518	1400W	PP2A	MESH:C496401	19052(Tax:10090)	Chemical	Gene	prevented|nsubj|START_ENTITY inhibitor|ccomp|prevented inhibitor|nsubj|END_ENTITY	Further , iNOS inhibitor 1400W , iNOS deficiency , NADPH oxidase inhibitor apocynin , or p47phox deficiency prevented the increase in PP2A activity and preserved barrier function .
20430367	0	1400W	41,46	iNOS	26,30	1400W	iNOS	MESH:C496401	18126(Tax:10090)	Chemical	Gene	inhibitor|nummod|START_ENTITY l-NAME|nummod|inhibitor differently|nmod:npmod|l-NAME affects|advmod|differently affects|nsubj|use use|nmod|END_ENTITY	Systemic use of selective iNOS inhibitor 1400W or non-selective NOS inhibitor l-NAME differently affects systemic nitric_oxide formation after oral Porphyromonas_gingivalis inoculation in mice .
6450617	0	14C-Methylated_beta-casein	0,26	plasmin	46,53	14C-Methylated beta-casein	plasmin	null	5340	Chemical	Gene	START_ENTITY|nmod|substrate substrate|nmod|END_ENTITY	14C-Methylated_beta-casein as a substrate for plasmin , and its application to the study of milk protein transformations .
17908923	0	14C-brivaracetam	35,51	SV2A	61,65	14C-brivaracetam	SV2A	null	9900	Chemical	Gene	Pharmacokinetics|nmod|START_ENTITY Pharmacokinetics|appos|END_ENTITY	Pharmacokinetics and metabolism of 14C-brivaracetam , a novel SV2A ligand , in healthy subjects .
6803541	0	14C-putrescine	48,62	diamine_oxidase	15,30	14C-putrescine	diamine oxidase	null	76507(Tax:10090)	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of diamine_oxidase in catabolism of 14C-putrescine in mice in vivo with special reference to the formation of gamma-aminobutyric_acid .
2133275	0	14C-serotonin	40,53	platelet-activating_factor	72,98	14C-serotonin	platelet-activating factor	null	9768	Chemical	Gene	assay|amod|START_ENTITY assay|nmod|END_ENTITY	Development of a sensitive and specific 14C-serotonin release assay for platelet-activating_factor -LRB- PAF -RRB- in human neutrophils .
23568778	0	15-Epi-lipoxin_A4	0,17	polyisoprenyl_diphosphate_phosphatase_1	86,125	15-Epi-lipoxin A4	polyisoprenyl diphosphate phosphatase 1	MESH:C040527	54704	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|regulating regulating|dobj|END_ENTITY	15-Epi-lipoxin_A4 inhibits human neutrophil superoxide anion generation by regulating polyisoprenyl_diphosphate_phosphatase_1 .
25649981	0	15-Hydroxyeicosatetraenoic_acid	0,31	MUC5AC	81,87	15-Hydroxyeicosatetraenoic acid	MUC5AC	null	4586	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	15-Hydroxyeicosatetraenoic_acid inhibits phorbol-12-myristate-13-Acetate-induced MUC5AC expression in NCI-H292 respiratory epithelial cells .
21737777	0	15-S-HETE	100,109	peroxisome_proliferator-activated_receptor-y	20,64	15-S-HETE	peroxisome proliferator-activated receptor-y	CHEBI:15558	5468	Chemical	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	Glutamine activates peroxisome_proliferator-activated_receptor-y in intestinal epithelial cells via 15-S-HETE and 13-OXO-ODE : a novel mechanism .
18671867	0	15-delta_PGJ2	32,45	TRPA1	76,81	15-delta PGJ2	TRPA1	null	277328(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Cutaneous_nociception evoked by 15-delta_PGJ2 via activation of ion channel TRPA1 .
317602	0	15-hydroxy	32,42	PGDH	72,76	15-hydroxy	PGDH	null	15446(Tax:10090)	Chemical	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Effect of ionizing radiation on 15-hydroxy prostaglandin_dehydrogenase -LRB- PGDH -RRB- activity in tissues .
317602	0	15-hydroxy	32,42	prostaglandin_dehydrogenase	43,70	15-hydroxy	prostaglandin dehydrogenase	null	15446(Tax:10090)	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Effect of ionizing radiation on 15-hydroxy prostaglandin_dehydrogenase -LRB- PGDH -RRB- activity in tissues .
17218971	0	15-hydroxyeicosatetraenoic_acid	8,39	ERK1/2	62,68	15-hydroxyeicosatetraenoic acid	ERK1/2	null	50689;116590	Chemical	Gene	START_ENTITY|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Role of 15-hydroxyeicosatetraenoic_acid in phosphorylation of ERK1/2 and caldesmon in pulmonary arterial smooth muscle cells .
19903832	0	15-hydroxyeicosatetraenoic_acid	0,31	peroxisome_proliferator-activated_receptor_beta	50,97	15-hydroxyeicosatetraenoic acid	peroxisome proliferator-activated receptor beta	null	5467	Chemical	Gene	agonist|nsubj|START_ENTITY agonist|amod|END_ENTITY	15-hydroxyeicosatetraenoic_acid is a preferential peroxisome_proliferator-activated_receptor_beta / delta agonist .
15358636	0	15-hydroxyprostaglandin	12,35	15-PGDH	51,58	15-hydroxyprostaglandin	15-PGDH	null	3248	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	NAD + - linked 15-hydroxyprostaglandin dehydrogenase -LRB- 15-PGDH -RRB- behaves as a tumor suppressor in lung_cancer .
8829211	0	15-hydroxyprostaglandin	15,38	PGDH	54,58	15-hydroxyprostaglandin	PGDH	null	3248	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	Immunoreactive 15-hydroxyprostaglandin dehydrogenase -LRB- PGDH -RRB- is reduced in fetal membranes from patients at preterm_delivery in the presence of infection .
23687300	0	15-keto-prostaglandin_E2	46,70	SMAD2/3	182,189	15-keto-prostaglandin E2	SMAD2/3	MESH:C026346	4087;4088	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|interaction interaction|nmod|END_ENTITY	15-hydroxyprostaglandin_dehydrogenase-derived 15-keto-prostaglandin_E2 inhibits cholangiocarcinoma cell growth through interaction with peroxisome_proliferator-activated_receptor-y , SMAD2/3 , and TAP63 proteins .
26590294	0	15-keto-prostaglandin_E2	46,70	SMAD2/3	182,189	15-keto-prostaglandin E2	SMAD2/3	MESH:C026346	4087;4088	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|interaction interaction|nmod|END_ENTITY	15-Hydroxyprostaglandin dehydrogenase-derived 15-keto-prostaglandin_E2 inhibits cholangiocarcinoma cell growth through interaction with peroxisome_proliferator-activated_receptor-y , SMAD2/3 , and TAP63 proteins .
8581419	0	15-ketosterols	22,36	cholesteryl_ester_transfer_protein	62,96	15-ketosterols	cholesteryl ester transfer protein	null	1071	Chemical	Gene	synthesis|nmod|START_ENTITY synthesis|nmod|END_ENTITY	Chemical synthesis of 15-ketosterols and their inhibitions of cholesteryl_ester_transfer_protein .
24566468	0	15d-PGJ2	21,29	AKT	72,75	15d-PGJ2	AKT	MESH:C477819	11651(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Cytotoxic effects of 15d-PGJ2 against osteosarcoma through ROS-mediated AKT and cell cycle inhibition .
19690198	0	15d-PGJ2	0,8	Akt	79,82	15d-PGJ2	Akt	MESH:C477819	207	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|inactivation inactivation|nmod|END_ENTITY	15d-PGJ2 induces apoptosis by reactive oxygen species-mediated inactivation of Akt in leukemia and colorectal_cancer cells and shows in vivo antitumor activity .
16864989	0	15d-PGJ2	10,18	CD40	40,44	15d-PGJ2	CD40	MESH:C477819	958	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effect of 15d-PGJ2 on the expression of CD40 and RANTES induced by IFN-gamma and TNF-alpha on renal tubular epithelial cells -LRB- HK-2 -RRB- .
16864989	0	15d-PGJ2	10,18	IFN-gamma	67,76	15d-PGJ2	IFN-gamma	MESH:C477819	3458	Chemical	Gene	Effect|nmod|START_ENTITY induced|nsubj|Effect induced|nmod|END_ENTITY	Effect of 15d-PGJ2 on the expression of CD40 and RANTES induced by IFN-gamma and TNF-alpha on renal tubular epithelial cells -LRB- HK-2 -RRB- .
25681332	0	15d-PGJ2	33,41	NLRP1	55,60	15d-PGJ2	NLRP1	MESH:C477819	195046(Tax:10090)	Chemical	Gene	Inhibits|nsubj|START_ENTITY Inhibits|dobj|END_ENTITY	The Cyclopentenone_Prostaglandin 15d-PGJ2 Inhibits the NLRP1 and NLRP3 Inflammasomes .
16208315	0	15d-Prostaglandin_J2	0,20	peroxisome_proliferator-activated_receptor-gamma	31,79	15d-Prostaglandin J2	peroxisome proliferator-activated receptor-gamma	null	25664(Tax:10116)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	15d-Prostaglandin_J2 activates peroxisome_proliferator-activated_receptor-gamma , promotes expression of catalase , and reduces inflammation , behavioral_dysfunction , and neuronal_loss after intracerebral_hemorrhage in rats .
9858313	0	16-Epiestriol	0,13	IFN-gamma	81,90	16-Epiestriol	IFN-gamma	MESH:D004964	15978(Tax:10090)	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|production production|amod|END_ENTITY	16-Epiestriol , a novel anti-inflammatory nonglycogenic steroid , does not inhibit IFN-gamma production by murine splenocytes .
20570159	0	16-bromoepiandrosterone	0,23	glucose_6-phosphate_dehydrogenase	79,112	16-bromoepiandrosterone	glucose 6-phosphate dehydrogenase	MESH:C032020	2539	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	16-bromoepiandrosterone , an activator of the mammalian immune system , inhibits glucose_6-phosphate_dehydrogenase from Trypanosoma_cruzi and is toxic to these parasites grown in culture .
1781296	0	16-methylene-17_alpha-acetoxy-19-norprogesterone	48,96	ST-1435	98,105	16-methylene-17 alpha-acetoxy-19-norprogesterone	ST-1435	null	1459466(Tax:273063)	Chemical	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Antifertility effect of the implant containing 16-methylene-17_alpha-acetoxy-19-norprogesterone -LRB- ST-1435 -RRB- -RSB- .
2831339	0	16-methylene_E2	88,103	17_beta-hydroxysteroid_dehydrogenase	40,76	16-methylene E2	17 beta-hydroxysteroid dehydrogenase	null	364773(Tax:10116)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Enhancement of estradiol potency by the 17_beta-hydroxysteroid_dehydrogenase inhibitor , 16-methylene_E2 in vivo .
16923571	0	17-AAG	92,98	HSP90	49,54	17-AAG	HSP90	MESH:C112765	3320	Chemical	Gene	Analysis|appos|START_ENTITY Analysis|nmod|expression expression|nmod|protein-90 protein-90|appos|END_ENTITY	Analysis of expression of heat_shock protein-90 -LRB- HSP90 -RRB- and the effects of HSP90 inhibitor -LRB- 17-AAG -RRB- in multiple_myeloma .
17157164	0	17-AAG	20,26	HSP90	4,9	17-AAG	HSP90	MESH:C112765	3320	Chemical	Gene	synergizes|nummod|START_ENTITY inhibitor|dobj|synergizes inhibitor|nsubj|END_ENTITY	The HSP90 inhibitor 17-AAG synergizes with doxorubicin and U0126 in anaplastic_large_cell_lymphoma irrespective of ALK expression .
21558407	0	17-AAG	82,88	HSP90	0,5	17-AAG	HSP90	MESH:C112765	3320	Chemical	Gene	tanespimycin|appos|START_ENTITY trial|nmod|tanespimycin breast_cancer|dep|trial effective|nmod|breast_cancer effective|nsubj|inhibition inhibition|compound|END_ENTITY	HSP90 inhibition is effective in breast_cancer : a phase II trial of tanespimycin -LRB- 17-AAG -RRB- plus trastuzumab in patients with HER2-positive metastatic breast_cancer progressing on trastuzumab .
22621282	0	17-AAG	67,73	HSP90	11,16	17-AAG	HSP90	MESH:C112765	3320	Chemical	Gene	Effects|appos|START_ENTITY Effects|nmod|17-allylamino-17-demethoxygeldanamycin 17-allylamino-17-demethoxygeldanamycin|compound|END_ENTITY	Effects of HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin -LRB- 17-AAG -RRB- on NEU/HER2 overexpressing mammary tumours in MMTV-NEU-NT mice monitored by Magnetic Resonance Spectroscopy .
22751135	0	17-AAG	16,22	HSP90	0,5	17-AAG	HSP90	MESH:C112765	111042(Tax:10090)	Chemical	Gene	inhibitor|nummod|START_ENTITY inhibitor|compound|END_ENTITY	HSP90 inhibitor 17-AAG selectively eradicates lymphoma stem cells .
23443787	0	17-AAG	28,34	HSP90	12,17	17-AAG	HSP90	MESH:C112765	3320	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|Effects Effects|nmod|END_ENTITY	-LSB- Effects of HSP90 inhibitor 17-AAG on cell cycle and apoptosis of human gastric_cancer cell lines SGC-7901 -RSB- .
24317439	0	17-AAG	63,69	HSP90	4,9	17-AAG	HSP90	MESH:C112765	3320	Chemical	Gene	synergizes|appos|START_ENTITY inhibitor|dobj|synergizes inhibitor|nsubj|END_ENTITY	The HSP90 inhibitor 17-N-allylamino-17-demethoxy_geldanamycin -LRB- 17-AAG -RRB- synergizes with cisplatin and induces apoptosis in cisplatin-resistant esophageal_squamous_cell_carcinoma cell lines via the Akt/XIAP pathway .
25227799	0	17-AAG	66,72	HSP90	76,81	17-AAG	HSP90	MESH:C112765	3320	Chemical	Gene	free|dobj|START_ENTITY free|nmod|expression expression|compound|END_ENTITY	Comparison of inhibitory effects of 17-AAG nanoparticles and free 17-AAG on HSP90 gene expression in breast_cancer .
26872308	0	17-AAG	39,45	HSP90	23,28	17-AAG	HSP90	MESH:C112765	3320	Chemical	Gene	inhibitor|nummod|START_ENTITY inhibitor|compound|END_ENTITY	Acquired resistance to HSP90 inhibitor 17-AAG and increased metastatic potential are associated with MUC1 expression in colon_carcinoma cells .
15972449	2	17-AAG	486,492	Hsp90	383,388	17-AAG	Hsp90	MESH:C112765	3320	Chemical	Gene	affinity|appos|START_ENTITY heat-shock_protein_90|nmod|affinity heat-shock_protein_90|appos|END_ENTITY	We found that ZAP-70 + CLL cells expressed activated heat-shock_protein_90 -LRB- Hsp90 -RRB- with high binding affinity for Hsp90 inhibitors , such as 17-allyl-amino-demethoxy-geldanamycin -LRB- 17-AAG -RRB- , whereas normal lymphocytes or ZAP-70 - CLL cells expressed nonactivated Hsp90 .
16155577	0	17-AAG	0,6	Hsp90	11,16	17-AAG	Hsp90	MESH:C112765	104434(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	17-AAG , an Hsp90 inhibitor , ameliorates polyglutamine-mediated motor neuron_degeneration .
16384610	0	17-AAG	16,22	Hsp90	0,5	17-AAG	Hsp90	MESH:C112765	3320	Chemical	Gene	inhibitor|nummod|START_ENTITY inhibitor|compound|END_ENTITY	Hsp90 inhibitor 17-AAG reduces ErbB2 levels and inhibits proliferation of the trastuzumab resistant breast_tumor cell line JIMT-1 .
16501598	0	17-AAG	0,6	Hsp90	11,16	17-AAG	Hsp90	MESH:C112765	3320	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	17-AAG , an Hsp90 inhibitor , causes kinetochore defects : a novel mechanism by which 17-AAG inhibits cell proliferation .
16501598	0	17-AAG	83,89	Hsp90	11,16	17-AAG	Hsp90	MESH:C112765	3320	Chemical	Gene	inhibits|nsubj|START_ENTITY mechanism|acl:relcl|inhibits defects|dep|mechanism causes|dobj|defects causes|nsubj|17-AAG 17-AAG|appos|inhibitor inhibitor|amod|END_ENTITY	17-AAG , an Hsp90 inhibitor , causes kinetochore defects : a novel mechanism by which 17-AAG inhibits cell proliferation .
17185503	0	17-AAG	74,80	Hsp90	57,62	17-AAG	Hsp90	MESH:C112765	3320	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Alleviating neurodegeneration by an anticancer agent : an Hsp90 inhibitor -LRB- 17-AAG -RRB- .
17221841	0	17-AAG	21,27	Hsp90	4,9	17-AAG	Hsp90	MESH:C112765	3320	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	The Hsp90 inhibitor , 17-AAG , prevents the ligand-independent nuclear localization of androgen_receptor in refractory_prostate_cancer cells .
19014912	4	17-AAG	546,552	Hsp90	658,663	17-AAG	Hsp90	MESH:C112765	3320	Chemical	Gene	present|nmod|START_ENTITY present|dobj|band band|amod|END_ENTITY	Unlike 17-AAG , which inhibits Hsp90 but enhances Hsp70 levels , ascorbate/menadione-treated cells present an additional Hsp90 protein band of about 70kDa as shown by Western blot analysis , suggesting Hsp90 cleavage .
19266313	0	17-AAG	0,6	Hsp90	10,15	17-AAG	Hsp90	MESH:C112765	104434(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	17-AAG , a Hsp90 inhibitor , attenuates the hypoxia-induced expression of SDF-1alpha_and_ILK in mouse RPE cells .
21517103	0	17-AAG	108,114	Hsp90	91,96	17-AAG	Hsp90	MESH:C112765	3320	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Nano self-assembly of recombinant human gelatin conjugated with a-tocopheryl_succinate for Hsp90 inhibitor , 17-AAG , delivery .
22161776	0	17-AAG	16,22	Hsp90	0,5	17-AAG	Hsp90	MESH:C112765	104434(Tax:10090)	Chemical	Gene	inhibitor|nummod|START_ENTITY inhibitor|compound|END_ENTITY	Hsp90 inhibitor 17-AAG inhibits progression of LuCaP35_xenograft_prostate_tumors to castration resistance .
23013759	0	17-AAG	0,6	Hsp90	29,34	17-AAG	Hsp90	MESH:C112765	111058(Tax:10090)	Chemical	Gene	mediated|nsubj|START_ENTITY mediated|xcomp|targeting targeting|nmod|limits limits|amod|END_ENTITY	17-AAG mediated targeting of Hsp90 limits tert activity in peritoneal_sarcoma related malignant_ascites by downregulating cyclin_D1 during cell cycle entry .
24523537	0	17-AAG	26,32	Hsp90	0,5	17-AAG	Hsp90	MESH:C112765	111058(Tax:10090)	Chemical	Gene	attenuates|nummod|START_ENTITY Ab-induced|nmod:npmod|attenuates synaptic_toxicity|amod|Ab-induced inhibitor|dobj|synaptic_toxicity inhibitor|nsubj|chaperone chaperone|amod|END_ENTITY	Hsp90 chaperone inhibitor 17-AAG attenuates Ab-induced synaptic_toxicity and memory_impairment .
24879994	0	17-AAG	83,89	Hsp90	17,22	17-AAG	Hsp90	MESH:C112765	3320	Chemical	Gene	potently|nmod|START_ENTITY inhibited|xcomp|potently inhibited|nsubj|SNX-25a SNX-25a|appos|inhibitor inhibitor|amod|END_ENTITY	SNX-25a , a novel Hsp90 inhibitor , inhibited human cancer growth more potently than 17-AAG .
25196280	0	17-AAG	16,22	Hsp90	0,5	17-AAG	Hsp90	MESH:C112765	3320	Chemical	Gene	inhibitor|nummod|START_ENTITY inhibitor|compound|END_ENTITY	Hsp90 inhibitor 17-AAG sensitizes Bcl-2 inhibitor -LRB- - -RRB- - gossypol by suppressing ERK-mediated protective autophagy and Mcl-1 accumulation in hepatocellular_carcinoma cells .
26922527	0	17-AAG	37,43	heat_shock_protein_90	4,25	17-AAG	heat shock protein 90	MESH:C112765	104434(Tax:10090)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	The heat_shock_protein_90 inhibitor , 17-AAG , attenuates thioacetamide induced liver fibrosis in mice .
18591380	0	17-AAG	26,32	hsp90	57,62	17-AAG	hsp90	MESH:C112765	3320	Chemical	Gene	enhances|dobj|START_ENTITY enhances|parataxis|function function|nsubj|abrogation abrogation|nmod|chaperone chaperone|amod|END_ENTITY	HDAC6 inhibition enhances 17-AAG -- mediated abrogation of hsp90 chaperone function in human leukemia cells .
20828379	0	17-Allylamino-17-demethoxygeldanamycin	0,38	Hsp90	74,79	17-Allylamino-17-demethoxygeldanamycin	Hsp90	MESH:C112765	3320	Chemical	Gene	induces|dep|START_ENTITY induces|dobj|downregulation downregulation|nmod|END_ENTITY	17-Allylamino-17-demethoxygeldanamycin induces downregulation of critical Hsp90 protein clients and results in cell cycle arrest and apoptosis of human urinary bladder_cancer cells .
15993848	0	17-Allylamino-17-demethoxygeldanamycin	0,38	TRAIL	49,54	17-Allylamino-17-demethoxygeldanamycin	TRAIL	MESH:C112765	8743	Chemical	Gene	overcomes|nsubj|START_ENTITY overcomes|dobj|resistance resistance|amod|END_ENTITY	17-Allylamino-17-demethoxygeldanamycin overcomes TRAIL resistance in colon_cancer cell lines .
20351313	0	17-DMAG	0,7	HSP90	139,144	17-DMAG	HSP90	MESH:C448659	111058(Tax:10090)	Chemical	Gene	targets|nummod|START_ENTITY targets|dep|implications implications|nmod|inhibition inhibition|compound|END_ENTITY	17-DMAG targets the nuclear factor-kappaB family of proteins to induce apoptosis in chronic_lymphocytic_leukemia : clinical implications of HSP90 inhibition .
22327510	0	17-DMAG	20,27	HSP90	0,5	17-DMAG	HSP90	MESH:C448659	104434(Tax:10090)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nummod|END_ENTITY	HSP90 inhibition by 17-DMAG reduces inflammation in J774 macrophages through suppression of Akt and nuclear factor-kB pathways .
22547655	0	17-DMAG	20,27	HSP90	0,5	17-DMAG	HSP90	MESH:C448659	3320	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nummod|END_ENTITY	HSP90 inhibition by 17-DMAG attenuates oxidative stress in experimental atherosclerosis .
22552283	0	17-DMAG	41,48	HSP90	25,30	17-DMAG	HSP90	MESH:C448659	111058(Tax:10090)	Chemical	Gene	inhibitor|nummod|START_ENTITY inhibitor|compound|END_ENTITY	Combination therapy with HSP90 inhibitor 17-DMAG reconditions the tumor microenvironment to improve recruitment of therapeutic T cells .
22694478	0	17-DMAG	66,73	HSP90	50,55	17-DMAG	HSP90	MESH:C448659	3320	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|effect effect|nmod|END_ENTITY	The apoptotic effect and associated signalling of HSP90 inhibitor 17-DMAG in hepatocellular_carcinoma cells .
23955587	0	17-DMAG	43,50	HSP90	26,31	17-DMAG	HSP90	MESH:C448659	104434(Tax:10090)	Chemical	Gene	administration|amod|START_ENTITY administration|nmod|inhibitor inhibitor|compound|END_ENTITY	Oral administration of an HSP90 inhibitor , 17-DMAG , intervenes tumor-cell infiltration into multiple organs and improves survival period for ATL model mice .
25374192	0	17-DMAG	66,73	HSP90	77,82	17-DMAG	HSP90	MESH:C448659	3320	Chemical	Gene	free|dobj|START_ENTITY free|nmod|expression expression|compound|END_ENTITY	Comparison of inhibitory effect of 17-DMAG nanoparticles and free 17-DMAG in HSP90 gene expression in lung_cancer .
22543833	0	17-DMAG	36,43	Heat_shock_protein_90	0,21	17-DMAG	Heat shock protein 90	MESH:C448659	3320	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Heat_shock_protein_90 inhibition by 17-DMAG lessens disease in the MRL/lpr mouse model of systemic_lupus_erythematosus .
25556684	0	17-DMAG	0,7	Hsp70	16,21	17-DMAG	Hsp70	MESH:C448659	15511(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	17-DMAG induces Hsp70 and protects the auditory hair cells from kanamycin ototoxicity in vitro .
12725864	0	17-DMAG	44,51	Hsp90	74,79	17-DMAG	Hsp90	MESH:C448659	3320	Chemical	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Crystal structure and molecular modeling of 17-DMAG in complex with human Hsp90 .
23843639	0	17-DMAG	16,23	Hsp90	0,5	17-DMAG	Hsp90	MESH:C448659	3320	Chemical	Gene	inhibitor|nummod|START_ENTITY inhibitor|compound|END_ENTITY	Hsp90 inhibitor 17-DMAG decreases expression of conserved herpesvirus protein kinases and reduces virus production in Epstein-Barr_virus-infected cells .
26764527	0	17-DMAG	65,72	Hsp90	35,40	17-DMAG	Hsp90	MESH:C448659	3320	Chemical	Gene	alvespimycin|appos|START_ENTITY alvespimycin|amod|END_ENTITY	A phase I trial of the intravenous Hsp90 inhibitor alvespimycin -LRB- 17-DMAG -RRB- in patients with relapsed chronic lymphocytic_leukemia / small lymphocytic_lymphoma .
20111068	0	17-DMAG	77,84	heat_shock_protein_90	21,42	17-DMAG	heat shock protein 90	MESH:C448659	3320	Chemical	Gene	KOS-1022|dep|START_ENTITY alvespimycin|appos|KOS-1022 alvespimycin|amod|END_ENTITY	Phase I study of the heat_shock_protein_90 inhibitor alvespimycin -LRB- KOS-1022 , 17-DMAG -RRB- administered intravenously twice weekly to patients with acute_myeloid_leukemia .
21767894	0	17-DMAG	66,73	heat_shock_protein_90	33,54	17-DMAG	heat shock protein 90	MESH:C448659	3320	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	The anti-proliferative effect of heat_shock_protein_90 inhibitor , 17-DMAG , on non-small-cell_lung_cancers being resistant to EGFR tyrosine kinase inhibitor .
26662567	0	17-DMAG	0,7	heat_shock_protein_90	16,37	17-DMAG	heat shock protein 90	MESH:C448659	3320	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|impairment impairment|amod|END_ENTITY	17-DMAG induces heat_shock_protein_90 functional impairment in human bladder_cancer cells : knocking down the hallmark traits of malignancy .
18410996	0	17-N-allilamino-17-demethoxygeldanamycin	85,125	Hsp90	63,68	17-N-allilamino-17-demethoxygeldanamycin	Hsp90	null	3320	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Radiosensitization of human vascular endothelial cells through Hsp90 inhibition with 17-N-allilamino-17-demethoxygeldanamycin .
16731752	0	17-allylamino-17-demethoxygeldanamycin	59,97	HSP90	43,48	17-allylamino-17-demethoxygeldanamycin	HSP90	MESH:C112765	3320	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|Potentiation Potentiation|nmod|activity activity|nmod|END_ENTITY	Potentiation of paclitaxel activity by the HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin in human ovarian_carcinoma cell lines with high levels of activated AKT .
23886587	0	17-allylamino-17-demethoxygeldanamycin	20,58	HSP90	4,9	17-allylamino-17-demethoxygeldanamycin	HSP90	MESH:C112765	3320	Chemical	Gene	modulates|amod|START_ENTITY inhibitor|dobj|modulates inhibitor|nsubj|END_ENTITY	The HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin modulates radiosensitivity by downregulating serine/threonine _ kinase_38 via Sp1 inhibition .
9744771	0	17-allylamino-17-demethoxygeldanamycin	27,65	HSP90	75,80	17-allylamino-17-demethoxygeldanamycin	HSP90	MESH:C112765	3320	Chemical	Gene	binds|amod|START_ENTITY binds|nmod|END_ENTITY	The benzoquinone_ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin .
11358818	0	17-allylamino-17-demethoxygeldanamycin	57,95	Hsp90	41,46	17-allylamino-17-demethoxygeldanamycin	Hsp90	MESH:C112765	3320	Chemical	Gene	results|amod|START_ENTITY inhibitor|dobj|results inhibitor|nsubj|Inhibition Inhibition|nmod|transduction transduction|nmod|END_ENTITY	Inhibition of signal transduction by the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin results in cytostasis and apoptosis .
16322212	0	17-allylamino-17-demethoxygeldanamycin	83,121	Hsp90	22,27	17-allylamino-17-demethoxygeldanamycin	Hsp90	MESH:C112765	3320	Chemical	Gene	targeted|nmod|START_ENTITY protein|acl:relcl|targeted protein|amod|END_ENTITY	Activated B-RAF is an Hsp90 client protein that is targeted by the anticancer drug 17-allylamino-17-demethoxygeldanamycin .
17016641	0	17-allylamino-17-demethoxygeldanamycin	58,96	Hsp90	42,47	17-allylamino-17-demethoxygeldanamycin	Hsp90	MESH:C112765	3320	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|effects effects|nmod|END_ENTITY	P53-dependent radiosensitizing effects of Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin on human oral_squamous_cell_carcinoma cell lines .
19956882	0	17-allylamino-17-demethoxygeldanamycin	90,128	Hsp90	74,79	17-allylamino-17-demethoxygeldanamycin	Hsp90	MESH:C112765	3320	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|radio-sensitization radio-sensitization|nmod|lines lines|nmod|END_ENTITY	p53 independent radio-sensitization of human lymphoblastoid cell lines by Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin .
15930315	0	17-allylamino-17-demethoxygeldanamycin	37,75	heat_shock_protein_90	4,25	17-allylamino-17-demethoxygeldanamycin	heat shock protein 90	MESH:C112765	104434(Tax:10090)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	The heat_shock_protein_90 inhibitor , 17-allylamino-17-demethoxygeldanamycin , enhances osteoclast formation and potentiates bone metastasis of a human breast_cancer cell line .
10962573	0	17-allylamino-17-demethoxygeldanamycin	101,139	hsp90	161,166	17-allylamino-17-demethoxygeldanamycin	hsp90	MESH:C112765	3320	Chemical	Gene	transduction|advcl|START_ENTITY profiling|amod|transduction profiling|appos|inhibitor inhibitor|nmod|chaperone chaperone|amod|END_ENTITY	Gene expression profiling of human colon_cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxygeldanamycin , an inhibitor of the hsp90 molecular chaperone .
16854066	0	17-amino-17-demethoxygeldanamycin	76,109	Hsp90	149,154	17-amino-17-demethoxygeldanamycin	Hsp90	null	3320	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Design , synthesis , and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent , water-soluble inhibitors of Hsp90 .
25105924	0	17-arylmethylamine-17-demethoxygeldanamycin	47,90	Hsp90	113,118	17-arylmethylamine-17-demethoxygeldanamycin	Hsp90	null	111058(Tax:10090)	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Design , synthesis and biological evaluation of 17-arylmethylamine-17-demethoxygeldanamycin derivatives as potent Hsp90 inhibitors .
26924297	0	17-b-estradiol	24,38	apolipoprotein_E	42,58	17-b-estradiol	apolipoprotein E	null	11816(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|receptors receptors|amod|END_ENTITY	Multifarious effects of 17-b-estradiol on apolipoprotein_E receptors gene expression during osteoblast differentiation in vitro .
24411201	0	17-b-hydroxysteroid	80,99	AKR1C3	115,121	17-b-hydroxysteroid	AKR1C3	null	8644	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	Morpholylureas are a new class of potent and selective inhibitors of the type 5 17-b-hydroxysteroid dehydrogenase -LRB- AKR1C3 -RRB- .
16939880	0	17-beta-Estradiol	0,17	COX-2	30,35	17-beta-Estradiol	COX-2	MESH:D004958	29527(Tax:10116)	Chemical	Gene	upregulates|amod|START_ENTITY END_ENTITY|nsubj|upregulates	17-beta-Estradiol upregulates COX-2 in the rat oviduct .
21445275	4	17-beta-estradiol	577,594	JMJD2B	608,614	17-beta-estradiol	JMJD2B	MESH:D004958	23030	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nummod|END_ENTITY	In addition , 17-beta-estradiol -LRB- E2 -RRB- induces JMJD2B expression in an ERa dependent manner .
10066447	4	17-beta-estradiol	610,627	PCDGF	590,595	17-beta-estradiol	PCDGF	MESH:D004958	2896	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	The stimulation of PCDGF expression by 17-beta-estradiol was observed as early as 4 hours and reached a maximum at 12 hours .
12811830	0	17-beta-estradiol	20,37	occludin	55,63	17-beta-estradiol	occludin	MESH:D004958	100506658	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Biphasic effects of 17-beta-estradiol on expression of occludin and transendothelial resistance and paracellular permeability in human vascular endothelial cells .
24705874	0	17-demethoxy-reblastatin	42,66	Hsp90	26,31	17-demethoxy-reblastatin	Hsp90	null	3320	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|effects effects|nmod|END_ENTITY	Anticancer effects of the Hsp90 inhibitor 17-demethoxy-reblastatin in human breast_cancer MDA-MB-231 cells .
21826987	0	17-dimethylamino-ethylaminogeldanamycin	43,82	heat_shock_protein_90	11,32	17-dimethylamino-ethylaminogeldanamycin	heat shock protein 90	null	3320	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|Effect Effect|nmod|END_ENTITY	-LSB- Effect of heat_shock_protein_90 inhibitor 17-dimethylamino-ethylaminogeldanamycin on TNfalpha-mediated apoptosis and TNF-induced NF-kappaB activation -RSB- .
19632771	0	17-dimethylaminoethylamino-17-demethoxygeldanamycin	37,88	RIP	19,22	17-dimethylaminoethylamino-17-demethoxygeldanamycin	RIP	MESH:C448659	8737	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Down-regulation of RIP expression by 17-dimethylaminoethylamino-17-demethoxygeldanamycin promotes TRAIL-induced apoptosis in breast_tumor cells .
17785360	0	17-hydroxyprogesterone	0,22	gonadotropin-releasing_hormone	36,66	17-hydroxyprogesterone	gonadotropin-releasing hormone	MESH:D019326	2796	Chemical	Gene	responses|amod|START_ENTITY responses|nmod|END_ENTITY	17-hydroxyprogesterone responses to gonadotropin-releasing_hormone disclose distinct phenotypes_of_functional_ovarian_hyperandrogenism_and_polycystic_ovary_syndrome .
3560940	0	17-hydroxyprogesterone	32,54	hCG	79,82	17-hydroxyprogesterone	hCG	MESH:D019326	3342	Chemical	Gene	response|amod|START_ENTITY response|acl|END_ENTITY	Comparison of saliva and plasma 17-hydroxyprogesterone time-course response to hCG administration in normal men .
4405142	0	17-ketosteroids	10,25	G6PD	73,77	17-ketosteroids	G6PD	MESH:D015068	2539	Chemical	Gene	START_ENTITY|nmod|activity activity|appos|END_ENTITY	Effect of 17-ketosteroids on glucose-6-phosphate_dehydrogenase activity -LRB- G6PD -RRB- and on G6PD isoenzymes .
4405142	0	17-ketosteroids	10,25	glucose-6-phosphate_dehydrogenase	29,62	17-ketosteroids	glucose-6-phosphate dehydrogenase	MESH:D015068	2539	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effect of 17-ketosteroids on glucose-6-phosphate_dehydrogenase activity -LRB- G6PD -RRB- and on G6PD isoenzymes .
23361463	0	17-nucleotide	97,110	eIF4G	135,140	17-nucleotide	eIF4G	null	1981	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Cation-dependent folding of 3 ' cap-independent translation elements facilitates interaction of a 17-nucleotide conserved sequence with eIF4G .
8301590	0	17-octadecynoic_acid	11,31	cytochrome_P450	66,81	17-octadecynoic acid	cytochrome P450	MESH:C047008	25251(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Effects of 17-octadecynoic_acid , a suicide-substrate inhibitor of cytochrome_P450 fatty_acid omega-hydroxylase , on renal function in rats .
7690750	5	17-phenyl_trinor_PGE2	712,733	EP1	738,741	17-phenyl trinor PGE2	EP2	null	19217(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	The binding was also inhibited by 17-phenyl_trinor_PGE2 -LRB- an EP1 agonist -RRB- and sulprostone -LRB- an EP1 and EP3 agonist -RRB- but not by 11-deoxy PGE1 -LRB- an EP2 and EP3 agonist -RRB- and butaprost -LRB- an EP2 agonist -RRB- .
24903735	0	17-phenylethylaminegeldanamycin	19,50	hsp90	73,78	17-phenylethylaminegeldanamycin	hsp90	null	3320	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Discovery of novel 17-phenylethylaminegeldanamycin derivatives as potent hsp90 inhibitors .
17617451	0	17AAG	16,21	HSP90	0,5	17AAG	HSP90	MESH:C112765	3320	Chemical	Gene	inhibitor|nummod|START_ENTITY inhibitor|compound|END_ENTITY	HSP90 inhibitor 17AAG causes apoptosis in ATRA-resistant acute promyelocytic_leukemia cells .
20920318	0	17AAG	101,106	HSP90	84,89	17AAG	HSP90	MESH:C112765	3320	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	Molecular signature of response and potential pathways related to resistance to the HSP90 inhibitor , 17AAG , in breast_cancer .
26364610	0	17AAG	21,26	HSP90	4,9	17AAG	HSP90	MESH:C112765	111058(Tax:10090)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	The HSP90 inhibitor , 17AAG , protects the intestinal stem cell niche and inhibits graft versus host_disease development .
17707057	0	17AAG	44,49	Hsp90	28,33	17AAG	Hsp90	MESH:C112765	111058(Tax:10090)	Chemical	Gene	inhibitor|nummod|START_ENTITY inhibitor|compound|END_ENTITY	Intratumor injection of the Hsp90 inhibitor 17AAG decreases tumor growth and induces apoptosis in a prostate_cancer xenograft model .
22941268	0	17AEP-GA	0,8	HSP90	13,18	17AEP-GA	HSP90	MESH:C578839	3320	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	17AEP-GA , an HSP90 antagonist , is a potent inhibitor of glioblastoma cell proliferation , survival , migration and invasion .
19380458	0	17Beta-estradiol	0,16	11beta-hydroxysteroid_dehydrogenase_type_1	26,68	17Beta-estradiol	11beta-hydroxysteroid dehydrogenase type 1	MESH:D004958	3290	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	17Beta-estradiol inhibits 11beta-hydroxysteroid_dehydrogenase_type_1 activity in rodent adipocytes .
15110759	0	17Beta-estradiol	0,16	CrkL	50,54	17Beta-estradiol	CrkL	MESH:D004958	1399	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|translocation translocation|nmod|END_ENTITY	17Beta-estradiol induces nuclear translocation of CrkL at the window of embryo implantation .
12204776	0	17Beta-estradiol	0,16	IL-8	113,117	17Beta-estradiol	IL-8	MESH:D004958	3576	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|adhesion adhesion|nmod|leukocytes leukocytes|nmod|TNF-alpha TNF-alpha|acl|stimulated stimulated|advcl|blocking blocking|dobj|secretion secretion|amod|END_ENTITY	17Beta-estradiol inhibits the adhesion of leukocytes in TNF-alpha stimulated human endothelial cells by blocking IL-8 and MCP-1 secretion , but not its transcription .
20378727	0	17Beta-estradiol	0,16	IL-8	26,30	17Beta-estradiol	IL-8	MESH:D004958	3576	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	17Beta-estradiol inhibits IL-8 in cystic_fibrosis by up-regulating secretory leucoprotease inhibitor .
12787135	0	17Beta-estradiol	0,16	MCP-1	26,31	17Beta-estradiol	MCP-1	MESH:D004958	6347	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	17Beta-estradiol inhibits MCP-1 production in human keratinocytes .
10912468	0	17Beta-estradiol	0,16	endothelin-1	27,39	17Beta-estradiol	endothelin-1	MESH:D004958	1906	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	17Beta-estradiol modulates endothelin-1 expression and release in human endothelial cells .
19003958	0	17Beta-estradiol	0,16	estrogen_receptor_alpha	95,118	17Beta-estradiol	estrogen receptor alpha	MESH:D004958	13982(Tax:10090)	Chemical	Gene	regulation|amod|START_ENTITY regulation|dep|role role|nmod|END_ENTITY	17Beta-estradiol regulation of the mRNA expression of T-type calcium channel subunits : role of estrogen_receptor_alpha and estrogen_receptor_beta .
20554954	0	17Beta-estradiol	0,16	estrogen_receptor_alpha	92,115	17Beta-estradiol	estrogen receptor alpha	MESH:D004958	13982(Tax:10090)	Chemical	Gene	promotes|dep|START_ENTITY promotes|nmod|END_ENTITY	17Beta-estradiol promotes TLR4-triggered proinflammatory mediator production through direct estrogen_receptor_alpha signaling in macrophages in vivo .
9348179	0	17Beta-estradiol	0,16	interleukin-6	73,86	17Beta-estradiol	interleukin-6	MESH:D004958	16193(Tax:10090)	Chemical	Gene	effects|amod|START_ENTITY D3|nsubj|effects D3|nmod|production production|amod|END_ENTITY	17Beta-estradiol antagonizes effects of 1alpha,25-dihydroxyvitamin _ D3 on interleukin-6 production and osteoclast-like cell formation in mouse bone marrow primary cultures .
20237333	0	17Beta-estradiol	0,16	leptin	26,32	17Beta-estradiol	leptin	MESH:D004958	3952	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	17Beta-estradiol enhances leptin expression in human placental cells through genomic and nongenomic actions .
10440269	0	17_Beta-estradiol	0,17	VEGF_receptor-2	28,43	17 Beta-estradiol	VEGF receptor-2	MESH:D004958	407170(Tax:9913)	Chemical	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	17_Beta-estradiol increases VEGF_receptor-2 and promotes DNA synthesis in retinal microvascular endothelial cells .
12967949	0	17_Beta-estradiol	0,17	endothelin_receptor_type_B	46,72	17 Beta-estradiol	endothelin receptor type B	MESH:D004958	50672(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	17_Beta-estradiol regulates the expression of endothelin_receptor_type_B in the heart .
2078644	0	17_Beta-estradiol	1,18	haptoglobin	36,47	17 Beta-estradiol	haptoglobin	MESH:D004958	101102413	Chemical	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	-LSB- 17_Beta-estradiol interaction with haptoglobin and its complex with hemoglobin -RSB- .
15304426	0	17_alpha-ethinylestradiol	58,83	CYP3A4	19,25	17 alpha-ethinylestradiol	CYP3A4	CHEBI:4903	1576	Chemical	Gene	metabolism|nmod|START_ENTITY involvement|nmod|metabolism involvement|nmod|END_ENTITY	The involvement of CYP3A4 and CYP2C9 in the metabolism of 17_alpha-ethinylestradiol .
20843480	0	17_b-estradiol	11,25	intracellular_adhesion_molecule-1	56,89	17 b-estradiol	intracellular adhesion molecule-1	null	3383	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effects of 17_b-estradiol on lipopolysacharride-induced intracellular_adhesion_molecule-1 mRNA expression and Ca + homeostasis alteration in human endothelial cells .
12829428	0	17_beta-Estradiol	0,17	angiotensin_II	27,41	17 beta-Estradiol	angiotensin II	MESH:D004958	183	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	17_beta-Estradiol inhibits angiotensin_II activation of area postrema neurons .
1958511	0	17_beta-estradiol	0,17	E2DH	33,37	17 beta-estradiol	E2DH	MESH:D004958	3292	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	17_beta-estradiol dehydrogenase -LRB- E2DH -RRB- activity in T47D cells .
12697671	0	17_beta-estradiol	80,97	E2F-1	55,60	17 beta-estradiol	E2F-1	MESH:D004958	1869	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Cell context-dependent differences in the induction of E2F-1 gene expression by 17_beta-estradiol in MCF-7 and ZR-75 cells .
11893775	0	17_beta-estradiol	35,52	HDL3	72,76	17 beta-estradiol	HDL3	MESH:D004958	53369	Chemical	Gene	START_ENTITY|nmod|presence presence|nmod|END_ENTITY	LCAT facilitates transacylation of 17_beta-estradiol in the presence of HDL3 subfraction .
3665838	0	17_beta-estradiol	36,53	Progesterone_receptor	0,21	17 beta-estradiol	Progesterone receptor	MESH:D004958	5241	Chemical	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Progesterone_receptor regulation by 17_beta-estradiol in human endometrial_carcinoma grown in nude_mice .
3402389	0	17_beta-estradiol	84,101	androgen_receptor	17,34	17 beta-estradiol	androgen receptor	MESH:D004958	367	Chemical	Gene	actions|nmod|START_ENTITY END_ENTITY|nmod|actions	Mediation by the androgen_receptor of the stimulatory and antiandrogenic actions of 17_beta-estradiol on the growth of androgen-sensitive Shionogi mammary_carcinoma cells in culture .
9575958	0	17_beta-estradiol	22,39	angiotensin_II	89,103	17 beta-estradiol	angiotensin II	MESH:D004958	24179(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|role role|nmod|END_ENTITY	Hemodynamic effect of 17_beta-estradiol in absence of NO in ovariectomized rats : role of angiotensin_II .
1733196	0	17_beta-estradiol	5,22	c-fos	44,49	17 beta-estradiol	c-fos	MESH:D004958	2353	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Both 17_beta-estradiol and tamoxifen induce c-fos messenger ribonucleic acid expression in human endometrial_carcinoma grown in nude_mice .
2265431	0	17_beta-estradiol	11,28	c-myc	32,37	17 beta-estradiol	c-myc	MESH:D004958	24577(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effects of 17_beta-estradiol on c-myc and c-Ha-ras expression in the liver of ovariectomized female rats .
8853349	0	17_beta-estradiol	11,28	endothelin-1	68,80	17 beta-estradiol	endothelin-1	MESH:D004958	403424(Tax:9615)	Chemical	Gene	responses|amod|START_ENTITY Effects|nmod|responses Effects|nmod|END_ENTITY	Effects of 17_beta-estradiol on coronary microvascular responses to endothelin-1 .
8175711	0	17_beta-estradiol	52,69	interleukin-6	19,32	17 beta-estradiol	interleukin-6	MESH:D004958	3569	Chemical	Gene	DNA|amod|START_ENTITY Down-modulation|nmod|DNA Down-modulation|nmod|expression expression|amod|END_ENTITY	Down-modulation of interleukin-6 gene expression by 17_beta-estradiol in the absence of high affinity DNA binding by the estrogen_receptor .
9199508	0	17_beta-estradiol	47,64	interleukin-6	14,27	17 beta-estradiol	interleukin-6	MESH:D004958	3569	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Repression of interleukin-6 gene expression by 17_beta-estradiol : inhibition of the DNA-binding activity of the transcription factors NF-IL6 and NF-kappa_B by the estrogen_receptor .
14636471	0	17_beta-estradiol	16,33	osteoprotegerin	55,70	17 beta-estradiol	osteoprotegerin	MESH:D004958	4982	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- The effects of 17_beta-estradiol on the expression of osteoprotegerin , the ligand of osteoprotegerin and related cytokines in osteosarcoma MG63 cells -RSB- .
3481542	0	17_beta-hydroxysteroid	35,57	17_beta-HSD	73,84	17 beta-hydroxysteroid	17 beta-HSD	CHEBI:35343	364773(Tax:10116)	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|dep|END_ENTITY	Immunocytochemical localization of 17_beta-hydroxysteroid dehydrogenase -LRB- 17_beta-HSD -RRB- , and its relation to the ultrastructure of steroidogenic cells in immature and mature rat ovaries .
8240983	0	17_beta-hydroxysteroid	79,101	interleukin-6	62,75	17 beta-hydroxysteroid	interleukin-6	CHEBI:35343	3569	Chemical	Gene	activity|amod|START_ENTITY END_ENTITY|nmod|activity	The anti-estrogen tamoxifen blocks the stimulatory effects of interleukin-6 on 17_beta-hydroxysteroid dehydrogenase activity in MCF-7 cells .
23747343	0	17a-ethynylestradiol	90,110	Estrogen_receptor-a	0,19	17a-ethynylestradiol	Estrogen receptor-a	null	2099	Chemical	Gene	mediates|advcl|START_ENTITY mediates|nsubj|END_ENTITY	Estrogen_receptor-a mediates human multidrug_resistance_associated_protein_3 induction by 17a-ethynylestradiol .
16125105	0	17alpha,24-dihydroxyergosterol	80,110	p450scc	49,56	17alpha,24-dihydroxyergosterol	p450scc	MESH:C507305	1583	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|nmod|END_ENTITY	Enzymatic metabolism of ergosterol by cytochrome p450scc to biologically active 17alpha,24-dihydroxyergosterol .
14977872	0	17alpha-ethinyl_estradiol	3,28	cytochrome_P450_2C19	45,65	17alpha-ethinyl estradiol	cytochrome P450 2C19	CHEBI:4903	1557	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Is 17alpha-ethinyl_estradiol an inhibitor of cytochrome_P450_2C19 ?
12643983	0	17alpha-ethinylestradiol	23,47	vitellogenin	116,128	17alpha-ethinylestradiol	vitellogenin	CHEBI:4903	101882735	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of exposure to 17alpha-ethinylestradiol during early development on sexual differentiation and induction of vitellogenin in zebrafish -LRB- Danio_rerio -RRB- .
16783621	0	17alpha-ethinylestradiol	126,150	vitellogenin	14,26	17alpha-ethinylestradiol	vitellogenin	CHEBI:4903	101882735	Chemical	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|induction induction|compound|END_ENTITY	Comparison of vitellogenin induction , sex ratio , and gonad morphology between zebrafish and Japanese_medaka after exposure to 17alpha-ethinylestradiol and 17beta-trenbolone .
16606610	0	17alpha-ethynylestradiol	33,57	Estrogen_receptor_alpha	0,23	17alpha-ethynylestradiol	Estrogen receptor alpha	CHEBI:4903	13982(Tax:10090)	Chemical	Gene	mediates|xcomp|START_ENTITY mediates|nsubj|END_ENTITY	Estrogen_receptor_alpha mediates 17alpha-ethynylestradiol causing hepatotoxicity .
11078439	0	17alpha-hydroxyprogesterone	63,90	renin	164,169	17alpha-hydroxyprogesterone	renin	MESH:D019326	5972	Chemical	Gene	active|amod|START_ENTITY END_ENTITY|amod|active	Plasma endothelin and LH-RH , LH , FSH , prolactin , progesterone , 17alpha-hydroxyprogesterone , estrone , 17beta-estradiol , delta4-androstenedione , testosterone , active renin , angiotensin-II and ANP levels in blood and LH , estrone and 17beta-estradiol and pregnanediol levels in urine of normal cycling women .
22659940	0	17b-Estradiol	53,66	AHR	22,25	17b-Estradiol	AHR	null	25690(Tax:10116)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of uterine AHR battery gene expression by 17b-Estradiol is predominantly mediated by estrogen receptor a .
26441237	0	17b-Estradiol	0,13	ASIC	23,27	17b-Estradiol	ASIC	null	41	Chemical	Gene	Activity|amod|START_ENTITY Activity|compound|END_ENTITY	17b-Estradiol Enhances ASIC Activity in Primary Sensory Neurons to Produce Sex Difference in Acidosis-Induced_Nociception .
22835949	0	17b-Estradiol	0,13	Akt	86,89	17b-Estradiol	Akt	null	24185(Tax:10116)	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|pathway pathway|compound|END_ENTITY	17b-Estradiol protects the liver against cold_ischemia / reperfusion injury through the Akt kinase pathway .
25523052	0	17b-Estradiol	0,13	Estrogen_Receptor_a	52,71	17b-Estradiol	Estrogen Receptor a	null	13982(Tax:10090)	Chemical	Gene	Expansion|amod|START_ENTITY Expansion|nmod|END_ENTITY	17b-Estradiol Attenuates Hematoma Expansion Through Estrogen_Receptor_a / Silent_Information_Regulator_1 / Nuclear Factor-kappa B Pathway in Hyperglycemic_Intracerebral_Hemorrhage Mice .
21993891	0	17b-Estradiol	0,13	G_protein-coupled_estrogen_receptor_1	77,114	17b-Estradiol	G protein-coupled estrogen receptor 1	null	76854(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	17b-Estradiol induces nongenomic effects in renal intercalated cells through G_protein-coupled_estrogen_receptor_1 .
25576195	0	17b-Estradiol	0,13	MMP-3	116,121	17b-Estradiol	MMP-3	null	171045(Tax:10116)	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|apoptosis apoptosis|acl|induced induced|nmod|END_ENTITY	17b-Estradiol protects against apoptosis induced by interleukin-1b in rat nucleus pulposus cells by down-regulating MMP-3 and MMP-13 .
22180637	0	17b-Estradiol	0,13	cyclin_A1	24,33	17b-Estradiol	cyclin A1	null	295052(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	17b-Estradiol regulates cyclin_A1 and cyclin_B1 gene expression in adult rat seminiferous tubules .
24492894	0	17b-Estradiol	0,13	estrogen_receptor_a	62,81	17b-Estradiol	estrogen receptor a	null	2099	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	17b-Estradiol induces sulfotransferase 2A1 expression through estrogen_receptor_a .
23567159	0	17b-Estradiol	0,13	growth_hormone	35,49	17b-Estradiol	growth hormone	null	2688	Chemical	Gene	modulates|amod|START_ENTITY END_ENTITY|nsubj|modulates	17b-Estradiol positively modulates growth_hormone signaling through the reduction of SOCS2 negative feedback in human osteoblasts .
26264729	0	17b-Estradiol	0,13	huntingtin	24,34	17b-Estradiol	huntingtin	null	29424(Tax:10116)	Chemical	Gene	modulates|amod|START_ENTITY END_ENTITY|nsubj|modulates	17b-Estradiol modulates huntingtin levels in rat tissues and in human neuroblastoma cell line .
20053478	0	17b-Estradiol	0,13	insulin-degrading_enzyme	24,48	17b-Estradiol	insulin-degrading enzyme	null	25700(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	17b-Estradiol regulates insulin-degrading_enzyme expression via an ERb/PI3-K pathway in hippocampus : relevance to Alzheimer 's _ prevention .
22354782	0	17b-Estradiol	0,13	prolactin	28,37	17b-Estradiol	prolactin	null	24683(Tax:10116)	Chemical	Gene	modulates|amod|START_ENTITY modulates|dep|secretion secretion|compound|END_ENTITY	17b-Estradiol modulates the prolactin secretion induced by TRH through membrane estrogen receptors via PI3K/Akt in female rat anterior pituitary cell culture .
24371388	0	17b-Hydroxysteroid	31,49	AKR1C3	65,71	17b-Hydroxysteroid	AKR1C3	null	8644	Chemical	Gene	Protein|amod|START_ENTITY Protein|appos|END_ENTITY	Decreased Expression of Type 5 17b-Hydroxysteroid Dehydrogenase -LRB- AKR1C3 -RRB- Protein Identified in Human Diabetic Skin Tissue .
26969072	0	17b-estradiol	56,69	Akt	151,154	17b-estradiol	Akt	null	207	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Lambda-cyhalothrin disrupts the up-regulation effect of 17b-estradiol on post-synaptic_density_95 protein expression via estrogen_receptor_a-dependent Akt pathway .
21327582	0	17b-estradiol	0,13	BCL2	133,137	17b-estradiol	BCL2	null	596	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|activation activation|nmod|END_ENTITY	17b-estradiol protects dopaminergic neurons in organotypic slice of mesencephalon by MAPK-mediated activation of anti-apoptosis gene BCL2 .
20883830	0	17b-estradiol	14,27	CYP1A1	42,48	17b-estradiol	CYP1A1	null	1543	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Inhibition of 17b-estradiol activation by CYP1A1 : genotype - and regioselective inhibition by St. John 's Wort and several natural polyphenols .
25451689	0	17b-estradiol	54,67	CerS4	19,24	17b-estradiol	CerS4	null	67260(Tax:10090)	Chemical	Gene	upregulated|nmod|START_ENTITY upregulated|nsubjpass|END_ENTITY	Ceramide synthases CerS4 and CerS5 are upregulated by 17b-estradiol and GPER1 via AP-1 in human breast_cancer cells .
21040551	0	17b-estradiol	35,48	Estrogen_receptor_a	0,19	17b-estradiol	Estrogen receptor a	null	2099	Chemical	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	Estrogen_receptor_a -LRB- ERa -RRB- mediates 17b-estradiol -LRB- E2 -RRB- - activated expression of HBO1 .
25287328	0	17b-estradiol	79,92	Protein_kinase_D1	0,17	17b-estradiol	Protein kinase D1	null	5587	Chemical	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Protein_kinase_D1 regulates ERa-positive breast_cancer cell growth response to 17b-estradiol and contributes to poor prognosis in patients .
21898560	0	17b-estradiol	26,39	Vitellogenin	0,12	17b-estradiol	Vitellogenin	null	101882735	Chemical	Gene	induction|advcl|START_ENTITY induction|nsubj|END_ENTITY	Vitellogenin induction by 17b-estradiol and 17a-ethynylestradiol in male Murray_rainbowfish -LRB- Melanotaenia fluviatilis -RRB- .
26526225	0	17b-estradiol	14,27	calcitonin_gene-related_peptide	50,81	17b-estradiol	calcitonin gene-related peptide	null	796	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	The effect of 17b-estradiol on gene expression of calcitonin_gene-related_peptide and some pro-inflammatory mediators in peripheral blood mononuclear cells from patients with pure menstrual_migraine .
26240989	0	17b-estradiol	54,67	glucose_transporter_3	82,103	17b-estradiol	glucose transporter 3	null	6515	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Akt and cAMP_response_element_binding_protein mediate 17b-estradiol regulation of glucose_transporter_3 expression in human SH-SY5Y neuroblastoma cell line .
23568502	0	17b-estradiol	0,13	miR-155	27,34	17b-estradiol	miR-155	null	406947	Chemical	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|amod|END_ENTITY	17b-estradiol up-regulates miR-155 expression and reduces TP53INP1 expression in MCF-7 breast_cancer cells .
22381103	0	17b-estradiol	11,24	monocyte_chemotactic_protein-1	43,73	17b-estradiol	monocyte chemotactic protein-1	null	6347	Chemical	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	Effects of 17b-estradiol on the release of monocyte_chemotactic_protein-1 and MAPK activity in monocytes stimulated with peritoneal fluid from endometriosis patients .
26969072	0	17b-estradiol	56,69	post-synaptic_density_95	73,97	17b-estradiol	post-synaptic density 95	null	1742	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Lambda-cyhalothrin disrupts the up-regulation effect of 17b-estradiol on post-synaptic_density_95 protein expression via estrogen_receptor_a-dependent Akt pathway .
22964384	0	17b-estradiol	19,32	ppt	45,48	17b-estradiol	ppt	null	5538	Chemical	Gene	START_ENTITY|nmod|serum serum|nmod|END_ENTITY	Immunodetection of 17b-estradiol in serum at ppt level by microcantilever resonators .
26022099	0	17b-estradiol	0,13	stearoyl-CoA_desaturase-1	22,47	17b-estradiol	stearoyl-CoA desaturase-1	null	6319	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	17b-estradiol induces stearoyl-CoA_desaturase-1 expression in estrogen receptor-positive breast_cancer cells .
23505113	0	17b-estrogen	12,24	C-reactive_protein	43,61	17b-estrogen	C-reactive protein	null	25419(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expressions expressions|nmod|END_ENTITY	-LSB- Effects of 17b-estrogen on expressions of C-reactive_protein and its mRNA of vascular smooth muscle cells in rats -RSB- .
21087665	0	17b-hydroxysteroid	21,39	AKR1C3	55,61	17b-hydroxysteroid	AKR1C3	null	8644	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	Inhibitors of type 5 17b-hydroxysteroid dehydrogenase -LRB- AKR1C3 -RRB- : overview and structural insights .
21151387	0	17b-hydroxysteroid	44,62	AKR1C3	78,84	17b-hydroxysteroid	AKR1C3	null	8644	Chemical	Gene	dehydrogenase|amod|START_ENTITY expression|nmod|dehydrogenase expression|appos|END_ENTITY	Differential expression of type 2 3a/type 5 17b-hydroxysteroid dehydrogenase -LRB- AKR1C3 -RRB- in tumors of the central nervous system .
21277203	0	17b-hydroxysteroid	99,117	AKR1C3	133,139	17b-hydroxysteroid	AKR1C3	null	8644	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	Discovery of substituted 3 - -LRB- phenylamino -RRB- benzoic_acids as potent and selective inhibitors of type 5 17b-hydroxysteroid dehydrogenase -LRB- AKR1C3 -RRB- .
23353746	0	17b-hydroxysteroid	74,92	AKR1C3	108,114	17b-hydroxysteroid	AKR1C3	null	8644	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	2,3-Diarylpropenoic _ acids as selective non-steroidal inhibitors of type-5 17b-hydroxysteroid dehydrogenase -LRB- AKR1C3 -RRB- .
25555457	0	17b-hydroxysteroid	67,85	AKR1C3	101,107	17b-hydroxysteroid	AKR1C3	null	8644	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	Screening baccharin analogs as selective inhibitors against type 5 17b-hydroxysteroid dehydrogenase -LRB- AKR1C3 -RRB- .
25555457	0	17b-hydroxysteroid	67,85	AKR1C3	101,107	17b-hydroxysteroid	AKR1C3	null	8644	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	Screening baccharin analogs as selective inhibitors against type 5 17b-hydroxysteroid dehydrogenase -LRB- AKR1C3 -RRB- .
23181892	0	17b-hydroxysteroid	59,77	HSD17B4	100,107	17b-hydroxysteroid	HSD17B4	null	3295	Chemical	Gene	type|amod|START_ENTITY type|appos|END_ENTITY	Specific combination of compound heterozygous mutations in 17b-hydroxysteroid dehydrogenase type 4 -LRB- HSD17B4 -RRB- defines a new subtype of D-bifunctional_protein deficiency .
21153120	0	17b-oestradiol	10,24	IL-2	42,46	17b-oestradiol	IL-2	null	3558	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effect of 17b-oestradiol on expression of IL-2 , IL-6 and IFN-y mRNA in human tonsillar cells .
22903146	0	17b_Hydroxysteroid	0,18	HSD17B12	42,50	17b Hydroxysteroid	HSD17B12	null	51144	Chemical	Gene	type|amod|START_ENTITY type|appos|END_ENTITY	17b_Hydroxysteroid dehydrogenase type 12 -LRB- HSD17B12 -RRB- is a marker of poor prognosis in ovarian_carcinoma .
11726795	0	17beta-Estradiol	0,16	c-Fos	45,50	17beta-Estradiol	c-Fos	MESH:D004958	314322(Tax:10116)	Chemical	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	17beta-Estradiol increases , aging decreases , c-Fos expression in the rat accessory_olfactory_bulb .
15607527	0	17beta-Estradiol	0,16	c-fos	36,41	17beta-Estradiol	c-fos	MESH:D004958	2353	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	17beta-Estradiol rapidly stimulates c-fos expression via the MAPK pathway in T84 cells .
17213481	0	17beta-Estradiol	0,16	endothelin-1	55,67	17beta-Estradiol	endothelin-1	MESH:D004958	24323(Tax:10116)	Chemical	Gene	vasoconstriction|amod|START_ENTITY induced|nsubj|vasoconstriction induced|nmod|trauma-hemorrhage trauma-hemorrhage|amod|END_ENTITY	17beta-Estradiol modulates vasoconstriction induced by endothelin-1 following trauma-hemorrhage .
17673296	0	17beta-Estradiol	0,16	estrogen_receptor-alpha	117,140	17beta-Estradiol	estrogen receptor-alpha	MESH:D004958	13982(Tax:10090)	Chemical	Gene	effects|nmod:poss|START_ENTITY mediated|nsubjpass|effects mediated|nmod|END_ENTITY	17beta-Estradiol 's salutary effects on splenic dendritic cell functions following trauma-hemorrhage are mediated via estrogen_receptor-alpha .
18252198	0	17beta-Estradiol	0,16	osteoprotegerin	26,41	17beta-Estradiol	osteoprotegerin	MESH:D004958	4982	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	17beta-Estradiol inhibits osteoprotegerin production by the estrogen_receptor-alpha-positive human breast_cancer cell line MCF-7 .
19873880	0	17beta-estradiol	11,27	Bax	50,53	17beta-estradiol	Bax	MESH:D004958	581	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of 17beta-estradiol on mRNA expression of Bax proapoptotic protein and DNA fragmentation level in the human adrenal cortex -RSB- .
12351557	0	17beta-estradiol	33,49	C-reactive_protein	86,104	17beta-estradiol	C-reactive protein	MESH:D004958	1401	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of tibolone and combined 17beta-estradiol and norethisterone_acetate on serum C-reactive_protein in healthy post-menopausal women : a randomized trial .
15706414	0	17beta-estradiol	63,79	CCN5	95,99	17beta-estradiol	CCN5	MESH:D004958	22403(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Stimulation of MCF-7 tumor progression in athymic nude_mice by 17beta-estradiol induces WISP-2 / CCN5 expression in xenografts : a novel signaling molecule in hormonal carcinogenesis .
9407016	0	17beta-estradiol	0,16	CREB	28,32	17beta-estradiol	CREB	MESH:D004958	81646(Tax:10116)	Chemical	Gene	attenuates|amod|START_ENTITY END_ENTITY|nsubj|attenuates	17beta-estradiol attenuates CREB decline in the rat hippocampus following seizure .
17947704	4	17beta-estradiol	573,589	CXCL8	632,637	17beta-estradiol	CXCL8	MESH:D004958	3576	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|nmod|END_ENTITY	In this study , we demonstrate that 17beta-estradiol -LRB- E2 -RRB- attenuates LPS-induced expression of CXCL8 in human peripheral blood monocytes .
16517565	0	17beta-estradiol	20,36	CXCR1	109,114	17beta-estradiol	CXCR1	MESH:D004958	3577	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of combined 17beta-estradiol with TCDD on secretion of chemokine IL-8 and expression of its receptor CXCR1 in endometriotic focus-associated cells in co-culture .
15499175	0	17beta-estradiol	31,47	CYP3A	73,78	17beta-estradiol	CYP3A	MESH:D004958	170509(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|compound|END_ENTITY	Effect of neonatal exposure of 17beta-estradiol and tamoxifen on hepatic CYP3A activity at developmental periods in rats .
20610538	0	17beta-estradiol	94,110	Caveolin_1	0,10	17beta-estradiol	Caveolin 1	MESH:D004958	857	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Caveolin_1 is required for the activation of endothelial_nitric_oxide_synthase in response to 17beta-estradiol .
10446910	0	17beta-estradiol	54,70	E2F1	30,34	17beta-estradiol	E2F1	MESH:D004958	1869	Chemical	Gene	cells|amod|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	Transcriptional activation of E2F1 gene expression by 17beta-estradiol in MCF-7 cells is regulated by NF-Y-Sp1 / estrogen_receptor interactions .
16687070	0	17beta-estradiol	22,38	ERRalpha	80,88	17beta-estradiol	ERRalpha	MESH:D004958	2101	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Regulatory effect of 17beta-estradiol on expression of orphan nuclear receptor ERRalpha in endometrial_carcinoma cell lines -RSB- .
16237062	0	17beta-estradiol	115,131	ERalpha	145,152	17beta-estradiol	ERalpha	MESH:D004958	13982(Tax:10090)	Chemical	Gene	acts|amod|START_ENTITY acts|nmod|END_ENTITY	Estrogen_receptor_alpha -LRB- ERalpha -RRB- deficiency in macrophages results in increased stimulation of CD4 + T cells while 17beta-estradiol acts through ERalpha to increase IL-4 and GATA-3 expression in CD4 + T cells independent of antigen presentation .
13679235	0	17beta-estradiol	14,30	ET-1	52,56	17beta-estradiol	ET-1	MESH:D004958	24323(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	Mechanisms of 17beta-estradiol on the production of ET-1 in ovariectomized rats .
12746293	0	17beta-estradiol	85,101	Estrogen_receptor	0,17	17beta-estradiol	Estrogen receptor	MESH:D004958	2099	Chemical	Gene	required|nmod|START_ENTITY END_ENTITY|parataxis|required	Estrogen_receptor / Sp1 complexes are required for induction of cad gene expression by 17beta-estradiol in breast_cancer cells .
11160157	0	17beta-estradiol	47,63	Estrogen_receptor_alpha	0,23	17beta-estradiol	Estrogen receptor alpha	MESH:D004958	13982(Tax:10090)	Chemical	Gene	effects|nmod:poss|START_ENTITY mediator|nmod|effects mediator|nsubj|END_ENTITY	Estrogen_receptor_alpha is a major mediator of 17beta-estradiol 's atheroprotective effects on lesion size in Apoe - / - mice .
16237062	0	17beta-estradiol	115,131	Estrogen_receptor_alpha	0,23	17beta-estradiol	Estrogen receptor alpha	MESH:D004958	13982(Tax:10090)	Chemical	Gene	acts|amod|START_ENTITY increase|nsubj|acts deficiency|advcl|increase deficiency|nsubj|END_ENTITY	Estrogen_receptor_alpha -LRB- ERalpha -RRB- deficiency in macrophages results in increased stimulation of CD4 + T cells while 17beta-estradiol acts through ERalpha to increase IL-4 and GATA-3 expression in CD4 + T cells independent of antigen presentation .
10499531	0	17beta-estradiol	24,40	GH_receptor	79,90	17beta-estradiol	GH receptor	MESH:D004958	14600(Tax:10090)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|nmod|END_ENTITY	Growth_hormone -LRB- GH -RRB- and 17beta-estradiol regulation of the expression of mouse GH_receptor and GH-binding_protein in cultured mouse hepatocytes .
15090535	0	17beta-estradiol	69,85	GPR30	31,36	17beta-estradiol	GPR30	MESH:D004958	2852	Chemical	Gene	mediates|advcl|START_ENTITY mediates|nsubj|END_ENTITY	The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast_cancer cells .
20065491	0	17beta-estradiol	88,104	G_protein-coupled_receptor	15,41	17beta-estradiol	G protein-coupled receptor	MESH:D004958	171104(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY involved|nmod|effects involved|nsubjpass|END_ENTITY	A new membrane G_protein-coupled_receptor -LRB- GPR30 -RRB- is involved in the cardiac effects of 17beta-estradiol in the male rat .
15291749	0	17beta-estradiol	10,26	GnRH-II	43,50	17beta-estradiol	GnRH-II	MESH:D004958	619516(Tax:9544)	Chemical	Gene	START_ENTITY|nmod|gene gene|amod|END_ENTITY	Effect of 17beta-estradiol on hypothalamic GnRH-II gene expression in the female rhesus_macaque .
17312152	0	17beta-estradiol	0,16	IL-1alpha	25,34	17beta-estradiol	IL-1alpha	MESH:D004958	3552	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	17beta-estradiol induces IL-1alpha gene expression in rheumatoid fibroblast-like synovial cells through estrogen_receptor_alpha -LRB- ERalpha -RRB- and augmentation of transcriptional activity of Sp1 by dissociating histone_deacetylase_2 from ERalpha .
10499497	0	17beta-estradiol	148,164	IL-6	33,37	17beta-estradiol	IL-6	MESH:D004958	24498(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY expression|dep|regulation expression|nmod|END_ENTITY	The expression of interleukin-6 -LRB- IL-6 -RRB- , IL-6_receptor , and gp130-kilodalton glycoprotein in the rat decidua and a decidual cell line : regulation by 17beta-estradiol and prolactin .
16711008	0	17beta-estradiol	11,27	IL-6	49,53	17beta-estradiol	IL-6	MESH:D004958	3569	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effects of 17beta-estradiol on the expression of IL-6 , IL-11 and NF-kappaB in human MG-63 osteoblast-like cell line .
16517565	0	17beta-estradiol	20,36	IL-8	73,77	17beta-estradiol	IL-8	MESH:D004958	3576	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of combined 17beta-estradiol with TCDD on secretion of chemokine IL-8 and expression of its receptor CXCR1 in endometriotic focus-associated cells in co-culture .
17392490	0	17beta-estradiol	42,58	Leptin	0,6	17beta-estradiol	Leptin	MESH:D004958	25608(Tax:10116)	Chemical	Gene	controlled|nmod|START_ENTITY controlled|nsubjpass|END_ENTITY	Leptin and its receptor are controlled by 17beta-estradiol in peripheral tissues of ovariectomized rats .
18421422	0	17beta-estradiol	105,121	OAS1g	143,148	17beta-estradiol	OAS1g	MESH:D004958	192281(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Characterization of oligoadenylate synthetase-1 expression in rat mammary gland and prostate : effects of 17beta-estradiol on the regulation of OAS1g in both tissues .
20200160	0	17beta-estradiol	44,60	PROS1	19,24	17beta-estradiol	PROS1	MESH:D004958	5627	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Down-regulation of PROS1 gene expression by 17beta-estradiol via estrogen_receptor_alpha -LRB- ERalpha -RRB- - Sp1 interaction recruiting receptor-interacting protein 140 and the corepressor-HDAC3 complex .
12603855	0	17beta-estradiol	0,16	RANTES	44,50	17beta-estradiol	RANTES	MESH:D004958	6352	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|nmod|END_ENTITY	17beta-estradiol inhibits the production of RANTES in human keratinocytes .
16504606	0	17beta-estradiol	57,73	UGT1A1	34,40	17beta-estradiol	UGT1A1	MESH:D004958	54658	Chemical	Gene	activity|nmod|START_ENTITY activity|nummod|END_ENTITY	Evaluation of mutation effects on UGT1A1 activity toward 17beta-estradiol using liquid chromatography-tandem mass spectrometry .
15706414	0	17beta-estradiol	63,79	WISP-2	88,94	17beta-estradiol	WISP-2	MESH:D004958	22403(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Stimulation of MCF-7 tumor progression in athymic nude_mice by 17beta-estradiol induces WISP-2 / CCN5 expression in xenografts : a novel signaling molecule in hormonal carcinogenesis .
12967350	0	17beta-estradiol	82,98	XIAP	23,27	17beta-estradiol	XIAP	MESH:D004958	63879(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Opposite regulation of XIAP and Smac/DIABLO in the rat endometrium in response to 17beta-estradiol at estrus .
17283243	0	17beta-estradiol	17,33	annexin_1	37,46	17beta-estradiol	annexin 1	MESH:D004958	25380(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	The influence of 17beta-estradiol on annexin_1 expression in the anterior pituitary of the female rat and in a folliculo-stellate cell line .
19819163	0	17beta-estradiol	50,66	beta-defensin-2	20,35	17beta-estradiol	beta-defensin-2	MESH:D004958	1673	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|expression expression|amod|END_ENTITY	Modulation of human beta-defensin-2 expression by 17beta-estradiol and progesterone in vaginal epithelial cells .
12947315	0	17beta-estradiol	54,70	c-Jun_N-terminal_kinase	19,42	17beta-estradiol	c-Jun N-terminal kinase	MESH:D004958	5599	Chemical	Gene	pathway|nmod|START_ENTITY pathway|amod|END_ENTITY	Suppression of the c-Jun_N-terminal_kinase pathway by 17beta-estradiol can preserve human islet functional mass from proinflammatory cytokine-induced destruction .
10478842	0	17beta-estradiol	53,69	c-fos	30,35	17beta-estradiol	c-fos	MESH:D004958	2353	Chemical	Gene	protooncogene|nmod|START_ENTITY protooncogene|amod|END_ENTITY	Transcriptional activation of c-fos protooncogene by 17beta-estradiol : mechanism of aryl_hydrocarbon_receptor-mediated inhibition .
15090535	0	17beta-estradiol	69,85	c-fos	46,51	17beta-estradiol	c-fos	MESH:D004958	2353	Chemical	Gene	mediates|advcl|START_ENTITY mediates|dobj|up-regulation up-regulation|amod|END_ENTITY	The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast_cancer cells .
11165043	0	17beta-estradiol	61,77	cathepsin_D	30,41	17beta-estradiol	cathepsin D	MESH:D004958	1509	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Transcriptional activation of cathepsin_D gene expression by 17beta-estradiol : mechanism of aryl_hydrocarbon_receptor-mediated inhibition .
16598773	0	17beta-estradiol	0,16	cdc25A	30,36	17beta-estradiol	cdc25A	MESH:D004958	993	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	17beta-estradiol -LRB- E2 -RRB- induces cdc25A gene expression in breast_cancer cells by genomic and non-genomic pathways .
11746525	0	17beta-estradiol	55,71	creatine_kinase_B	34,51	17beta-estradiol	creatine kinase B	MESH:D004958	24264(Tax:10116)	Chemical	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	Transcriptional activation of rat creatine_kinase_B by 17beta-estradiol in MCF-7 cells involves an estrogen responsive element and GC-rich sites .
15458742	0	17beta-estradiol	0,16	cyclooxygenase-1	122,138	17beta-estradiol	cyclooxygenase-1	MESH:D004958	5742	Chemical	Gene	production|amod|START_ENTITY production|nmod|expression expression|amod|END_ENTITY	17beta-estradiol up-regulates prostacyclin production in cultured human uterine myometrial cells via augmentation of both cyclooxygenase-1 and prostacyclin synthase expression .
20610538	0	17beta-estradiol	94,110	endothelial_nitric_oxide_synthase	45,78	17beta-estradiol	endothelial nitric oxide synthase	MESH:D004958	4846	Chemical	Gene	required|nmod|START_ENTITY required|nmod|activation activation|nmod|END_ENTITY	Caveolin_1 is required for the activation of endothelial_nitric_oxide_synthase in response to 17beta-estradiol .
11015337	0	17beta-estradiol	0,16	endothelin-1	27,39	17beta-estradiol	endothelin-1	MESH:D004958	1906	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|levels levels|amod|END_ENTITY	17beta-estradiol decreases endothelin-1 levels in the coronary circulation of postmenopausal women with coronary_artery_disease .
14730207	0	17beta-estradiol	0,16	endothelin-1	54,66	17beta-estradiol	endothelin-1	MESH:D004958	24323(Tax:10116)	Chemical	Gene	downregulates|amod|START_ENTITY angiotensin-II-induced|nsubj|downregulates angiotensin-II-induced|dobj|expression expression|amod|END_ENTITY	17beta-estradiol downregulates angiotensin-II-induced endothelin-1 gene expression in rat aortic smooth muscle cells .
15130882	0	17beta-estradiol	0,16	endothelin-1	48,60	17beta-estradiol	endothelin-1	MESH:D004958	1906	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	17beta-estradiol inhibits cyclic strain-induced endothelin-1 gene expression within vascular endothelial cells .
15224154	0	17beta-estradiol	127,143	endothelin-1	57,69	17beta-estradiol	endothelin-1	MESH:D004958	24323(Tax:10116)	Chemical	Gene	-RSB-|amod|START_ENTITY involvement|nmod|-RSB- involvement|nmod|cells cells|amod|caveolin-1 caveolin-1|nmod|inhibition inhibition|nmod|proliferation proliferation|amod|END_ENTITY	-LSB- Possible involvement of caveolin-1 in the inhibition of endothelin-1 induced proliferation of vascular smooth muscle cells by 17beta-estradiol -RSB- .
15838348	0	17beta-estradiol	57,73	endothelin-1	77,89	17beta-estradiol	endothelin-1	MESH:D004958	24323(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|overproduction overproduction|amod|END_ENTITY	Involvement of nitric_oxide in the suppressive effect of 17beta-estradiol on endothelin-1 overproduction in ischemic acute_renal_failure .
16741048	0	17beta-estradiol	0,16	endothelin-1	26,38	17beta-estradiol	endothelin-1	MESH:D004958	1906	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	17beta-estradiol inhibits endothelin-1 production and attenuates cerebral_vasospasm after experimental subarachnoid_hemorrhage .
16814412	0	17beta-estradiol	24,40	endothelin-1	49,61	17beta-estradiol	endothelin-1	MESH:D004958	1906	Chemical	Gene	administration|nmod|START_ENTITY reduces|nsubj|administration reduces|dobj|release release|amod|END_ENTITY	Acute administration of 17beta-estradiol reduces endothelin-1 release during pacing-induced ischemia .
21162282	0	17beta-estradiol	48,64	endothelin-1	86,98	17beta-estradiol	endothelin-1	MESH:D004958	1906	Chemical	Gene	START_ENTITY|nmod|production production|nmod|cells cells|amod|END_ENTITY	-LSB- Role of NO signal pathway in the inhibitory of 17beta-estradiol on the production of endothelin-1 in vascular smooth muscle cells -RSB- .
10662703	0	17beta-estradiol	0,16	estrogen_receptor-alpha	84,107	17beta-estradiol	estrogen receptor-alpha	MESH:D004958	13982(Tax:10090)	Chemical	Gene	START_ENTITY|dep|regulate regulate|nmod|pathway pathway|amod|END_ENTITY	17beta-estradiol and ICI-182780 regulate the hair follicle cycle in mice through an estrogen_receptor-alpha pathway .
11356664	0	17beta-estradiol	0,16	estrogen_receptor-alpha	98,121	17beta-estradiol	estrogen receptor-alpha	MESH:D004958	13982(Tax:10090)	Chemical	Gene	stimulates|amod|START_ENTITY stimulates|nmod|END_ENTITY	17beta-estradiol stimulates expression of osteoprotegerin by a mouse stromal cell line , ST-2 , via estrogen_receptor-alpha .
14507666	0	17beta-estradiol	25,41	estrogen_receptor-alpha	107,130	17beta-estradiol	estrogen receptor-alpha	MESH:D004958	13982(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY mediated|nsubjpass|effect mediated|nmod|END_ENTITY	The protective effect of 17beta-estradiol on experimental_autoimmune_encephalomyelitis is mediated through estrogen_receptor-alpha .
16169518	0	17beta-estradiol	39,55	estrogen_receptor-alpha	78,101	17beta-estradiol	estrogen receptor-alpha	MESH:D004958	2099	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Up-regulation of PI3K/Akt signaling by 17beta-estradiol through activation of estrogen_receptor-alpha , but not estrogen receptor-beta , and stimulates cell growth in breast_cancer cells .
17287365	0	17beta-estradiol	20,36	estrogen_receptor-alpha	132,155	17beta-estradiol	estrogen receptor-alpha	MESH:D004958	13982(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY mediated|nsubjpass|effects mediated|nmod|END_ENTITY	Salutary effects of 17beta-estradiol on T-cell signaling and cytokine production after trauma-hemorrhage are mediated primarily via estrogen_receptor-alpha .
17615152	0	17beta-estradiol	126,142	estrogen_receptor-alpha	48,71	17beta-estradiol	estrogen receptor-alpha	MESH:D004958	2099	Chemical	Gene	required|advcl|START_ENTITY required|nsubjpass|site site|nmod|END_ENTITY	A functional serine 118 phosphorylation site in estrogen_receptor-alpha is required for down-regulation of gene expression by 17beta-estradiol and 4-hydroxytamoxifen .
19654889	0	17beta-estradiol	0,16	estrogen_receptor-alpha	57,80	17beta-estradiol	estrogen receptor-alpha	MESH:D004958	13982(Tax:10090)	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|dobj|atherosclerosis atherosclerosis|nmod|mice mice|amod|END_ENTITY	17beta-estradiol prevents early-stage atherosclerosis in estrogen_receptor-alpha deficient female mice .
19996016	0	17beta-estradiol	91,107	estrogen_receptor-alpha	12,35	17beta-estradiol	estrogen receptor-alpha	MESH:D004958	13982(Tax:10090)	Chemical	Gene	action|nmod|START_ENTITY role|nmod|action plays|dobj|role plays|nsubj|END_ENTITY	Endothelial estrogen_receptor-alpha plays a crucial role in the atheroprotective action of 17beta-estradiol in low-density_lipoprotein_receptor-deficient mice .
20010956	0	17beta-estradiol	61,77	estrogen_receptor-alpha	9,32	17beta-estradiol	estrogen receptor-alpha	MESH:D004958	13982(Tax:10090)	Chemical	Gene	mediates|advcl|START_ENTITY mediates|nsubj|END_ENTITY	Neuronal estrogen_receptor-alpha mediates neuroprotection by 17beta-estradiol .
20196785	0	17beta-estradiol	13,29	estrogen_receptor-alpha	37,60	17beta-estradiol	estrogen receptor-alpha	MESH:D004958	2099	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|amod|END_ENTITY	Akt mediates 17beta-estradiol and/or estrogen_receptor-alpha inhibition of LPS-induced tumor necresis factor-alpha expression and myocardial cell apoptosis by suppressing the JNK1/2-NFkappaB pathway .
20448060	0	17beta-estradiol	0,16	estrogen_receptor-alpha	57,80	17beta-estradiol	estrogen receptor-alpha	MESH:D004958	13982(Tax:10090)	Chemical	Gene	inhibits|amod|START_ENTITY wound|nsubj|inhibits wound|nmod|mice mice|nmod|END_ENTITY	17beta-estradiol inhibits wound healing in male mice via estrogen_receptor-alpha .
12790785	0	17beta-estradiol	31,47	estrogen_receptor_alpha	70,93	17beta-estradiol	estrogen receptor alpha	MESH:D004958	2099	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Up-regulation of LRP16 mRNA by 17beta-estradiol through activation of estrogen_receptor_alpha -LRB- ERalpha -RRB- , but not ERbeta , and promotion of human breast_cancer MCF-7 cell proliferation : a preliminary report .
15496458	0	17beta-estradiol	86,102	estrogen_receptor_alpha	25,48	17beta-estradiol	estrogen receptor alpha	MESH:D004958	2099	Chemical	Gene	regulation|nmod|START_ENTITY localization|dep|regulation localization|compound|END_ENTITY	Palmitoylation-dependent estrogen_receptor_alpha membrane localization : regulation by 17beta-estradiol .
16574784	0	17beta-estradiol	71,87	estrogen_receptor_alpha	120,143	17beta-estradiol	estrogen receptor alpha	MESH:D004958	2099	Chemical	Gene	cells|amod|START_ENTITY induced|nmod|cells induced|nmod|proteins proteins|amod|END_ENTITY	Vascular endothelial growth factor receptor-2 expression is induced by 17beta-estradiol in ZR-75 breast_cancer cells by estrogen_receptor_alpha / Sp proteins .
17312152	0	17beta-estradiol	0,16	estrogen_receptor_alpha	104,127	17beta-estradiol	estrogen receptor alpha	MESH:D004958	2099	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|cells cells|nmod|END_ENTITY	17beta-estradiol induces IL-1alpha gene expression in rheumatoid fibroblast-like synovial cells through estrogen_receptor_alpha -LRB- ERalpha -RRB- and augmentation of transcriptional activity of Sp1 by dissociating histone_deacetylase_2 from ERalpha .
17452498	0	17beta-estradiol	24,40	estrogen_receptor_alpha	71,94	17beta-estradiol	estrogen receptor alpha	MESH:D004958	2099	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Differential effects of 17beta-estradiol on function and expression of estrogen_receptor_alpha , estrogen_receptor beta , and GPR30 in arteries and veins of patients with atherosclerosis .
18006642	0	17beta-estradiol	78,94	estrogen_receptor_alpha	127,150	17beta-estradiol	estrogen receptor alpha	MESH:D004958	2099	Chemical	Gene	cells|amod|START_ENTITY down-regulated|nmod|cells down-regulated|nmod|proteins proteins|amod|END_ENTITY	Vascular endothelial growth factor receptor-2 expression is down-regulated by 17beta-estradiol in MCF-7 breast_cancer cells by estrogen_receptor_alpha / Sp proteins .
19188600	0	17beta-estradiol	110,126	estrogen_receptor_alpha	34,57	17beta-estradiol	estrogen receptor alpha	MESH:D004958	13982(Tax:10090)	Chemical	Gene	actions|nmod|START_ENTITY dispensable|nmod|actions dispensable|nsubj|1 1|nmod|END_ENTITY	The transactivating function 1 of estrogen_receptor_alpha is dispensable for the vasculoprotective actions of 17beta-estradiol .
9419067	0	17beta-estradiol	11,27	glucose_transporter_1	31,52	17beta-estradiol	glucose transporter 1	MESH:D004958	24778(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effects of 17beta-estradiol on glucose_transporter_1 expression and endothelial cell survival following focal ischemia in the rats .
18217188	0	17beta-estradiol	0,16	glycogen_synthase_kinase-3beta	28,58	17beta-estradiol	glycogen synthase kinase-3beta	MESH:D004958	2932	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|activation activation|amod|END_ENTITY	17beta-estradiol attenuates glycogen_synthase_kinase-3beta activation and tau_hyperphosphorylation in Akt-independent manner .
10803586	0	17beta-estradiol	81,97	gonadotropin-releasing_hormone	14,44	17beta-estradiol	gonadotropin-releasing hormone	MESH:D004958	2796	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of gonadotropin-releasing_hormone and its receptor gene expression by 17beta-estradiol in cultured human granulosa-luteal cells .
17962348	0	17beta-estradiol	0,16	gonadotropin-releasing_hormone	122,152	17beta-estradiol	gonadotropin-releasing hormone	MESH:D004958	2796	Chemical	Gene	augments|amod|START_ENTITY augments|dep|currents currents|nmod|beta beta|nmod|GT1-7 GT1-7|amod|END_ENTITY	17beta-estradiol at physiological concentrations augments Ca -LRB- 2 + -RRB- - activated K + currents via estrogen receptor beta in the gonadotropin-releasing_hormone neuronal cell line GT1-7 .
15761212	0	17beta-estradiol	0,16	heparin-binding_epidermal_growth_factor-like_growth_factor	26,84	17beta-estradiol	heparin-binding epidermal growth factor-like growth factor	MESH:D004958	1839	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|amod|END_ENTITY	17beta-estradiol enhances heparin-binding_epidermal_growth_factor-like_growth_factor production in human keratinocytes .
10404809	0	17beta-estradiol	22,38	insulin-like_growth_factor_I	66,94	17beta-estradiol	insulin-like growth factor I	MESH:D004958	3479	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of intranasal 17beta-estradiol on bone turnover and serum insulin-like_growth_factor_I in postmenopausal women .
10499497	0	17beta-estradiol	148,164	interleukin-6	18,31	17beta-estradiol	interleukin-6	MESH:D004958	24498(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY expression|dep|regulation expression|nmod|IL-6 IL-6|amod|END_ENTITY	The expression of interleukin-6 -LRB- IL-6 -RRB- , IL-6_receptor , and gp130-kilodalton glycoprotein in the rat decidua and a decidual cell line : regulation by 17beta-estradiol and prolactin .
11395027	0	17beta-estradiol	103,119	interleukin-6	15,28	17beta-estradiol	interleukin-6	MESH:D004958	16193(Tax:10090)	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of interleukin-6 in atherosclerosis but not in the prevention of fatty_streak formation by 17beta-estradiol in apolipoprotein_E-deficient mice .
15528032	0	17beta-estradiol	22,38	interleukin-6	65,78	17beta-estradiol	interleukin-6	MESH:D004958	3569	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|secretion secretion|amod|END_ENTITY	Protective effects of 17beta-estradiol and trivalent_chromium on interleukin-6 secretion , oxidative stress , and adhesion of monocytes : relevance to heart_disease in postmenopausal women .
15762036	0	17beta-estradiol	11,27	interleukin-6	92,105	17beta-estradiol	interleukin-6	MESH:D004958	3569	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|acl|END_ENTITY	Effects of 17beta-estradiol , tamoxifen and raloxifene on the protein and mRNA expression of interleukin-6 , transforming_growth_factor-beta1 and insulin-like_growth_factor-1 in primary human osteoblast cultures .
16894332	0	17beta-estradiol	22,38	interleukin-6	73,86	17beta-estradiol	interleukin-6	MESH:D004958	3569	Chemical	Gene	administration|amod|START_ENTITY Effects|nmod|administration bioactive|nsubj|Effects bioactive|dobj|levels levels|amod|END_ENTITY	Effects of intranasal 17beta-estradiol administration on serum bioactive interleukin-6 and C-reactive_protein levels in healthy postmenopausal women .
9743240	0	17beta-estradiol	97,113	interleukin-6	14,27	17beta-estradiol	interleukin-6	MESH:D004958	16193(Tax:10090)	Chemical	Gene	inhibition|nmod|START_ENTITY Expression|dep|inhibition Expression|nmod|END_ENTITY	Expression of interleukin-6 in atherosclerotic_lesions of male ApoE-knockout mice : inhibition by 17beta-estradiol .
9792467	0	17beta-estradiol	11,27	interleukin-6	48,61	17beta-estradiol	interleukin-6	MESH:D004958	3569	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|production production|amod|END_ENTITY	Effects of 17beta-estradiol and progesterone on interleukin-6 production and proliferation of human umbilical vein endothelial cells .
12627042	0	17beta-estradiol	85,101	leptin	125,131	17beta-estradiol	leptin	MESH:D004958	3952	Chemical	Gene	therapy|nmod|START_ENTITY Effects|nmod|therapy Effects|nmod|levels levels|compound|END_ENTITY	Effects of bilateral ovariectomy and postoperative hormonal replacement therapy with 17beta-estradiol or raloxifene on serum leptin levels .
14567768	0	17beta-estradiol	90,106	leptin	7,13	17beta-estradiol	leptin	MESH:D004958	3952	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|dep|effect	Plasma leptin in postmenopausal women with coronary_artery_disease : effect of transdermal 17beta-estradiol and intermittent medroxyprogesterone_acetate .
22310000	0	17beta-estradiol	35,51	leptin	14,20	17beta-estradiol	leptin	MESH:D004958	3952	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Regulation of leptin expression by 17beta-estradiol in human placental cells involves membrane associated estrogen receptor alpha .
16280215	0	17beta-estradiol	11,27	matrix_metalloproteinase-1	31,57	17beta-estradiol	matrix metalloproteinase-1	MESH:D004958	4312	Chemical	Gene	START_ENTITY|nmod|synthesis synthesis|amod|END_ENTITY	Effects of 17beta-estradiol on matrix_metalloproteinase-1 synthesis by human dermal fibroblasts .
11817712	0	17beta-estradiol	11,27	membrane_type_1_matrix_metalloproteinase	49,89	17beta-estradiol	membrane type 1 matrix metalloproteinase	MESH:D004958	4323	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effects of 17beta-estradiol on the expression of membrane_type_1_matrix_metalloproteinase -LRB- MT1-MMP -RRB- and MMP-2 in human osteoblastic MG-63 cell cultures .
11078439	0	17beta-estradiol	101,117	renin	164,169	17beta-estradiol	renin	MESH:D004958	5972	Chemical	Gene	active|amod|START_ENTITY END_ENTITY|amod|active	Plasma endothelin and LH-RH , LH , FSH , prolactin , progesterone , 17alpha-hydroxyprogesterone , estrone , 17beta-estradiol , delta4-androstenedione , testosterone , active renin , angiotensin-II and ANP levels in blood and LH , estrone and 17beta-estradiol and pregnanediol levels in urine of normal cycling women .
9484906	0	17beta-estradiol	0,16	substance_P_receptor	28,48	17beta-estradiol	substance P receptor	MESH:D004958	24807(Tax:10116)	Chemical	Gene	stimulates|amod|START_ENTITY END_ENTITY|nsubj|stimulates	17beta-estradiol stimulates substance_P_receptor gene expression .
11014248	0	17beta-estradiol	0,16	thrombomodulin	48,62	17beta-estradiol	thrombomodulin	MESH:D004958	7056	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|END_ENTITY	17beta-estradiol , but not raloxifene , decreases thrombomodulin in the antithrombotic protein C pathway .
15237017	0	17beta-estradiol	89,105	thrombospondin-1	109,125	17beta-estradiol	thrombospondin-1	MESH:D004958	7057	Chemical	Gene	START_ENTITY|nmod|mRNA mRNA|amod|END_ENTITY	Effects of levonorgestrel , medroxyprogesterone_acetate , norethindrone , progesterone , and 17beta-estradiol on thrombospondin-1 mRNA in Ishikawa cells .
19130215	0	17beta-estradiol	0,16	transthyretin	25,38	17beta-estradiol	transthyretin	MESH:D004958	22139(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	17beta-estradiol induces transthyretin expression in murine choroid plexus via an oestrogen receptor dependent pathway .
15582534	0	17beta-hydroxysteroid	130,151	AKR1C3	72,78	17beta-hydroxysteroid	AKR1C3	CHEBI:35343	8644	Chemical	Gene	dehydrogenase|amod|START_ENTITY type|dep|dehydrogenase type|dep|type END_ENTITY|dep|type	Characterization of a monoclonal antibody for human aldo-keto reductase AKR1C3 -LRB- type 2_3alpha-hydroxysteroid_dehydrogenase / type 5 17beta-hydroxysteroid dehydrogenase -RRB- ; immunohistochemical detection in breast and prostate .
19010312	0	17beta-hydroxysteroid	7,28	AKR1C3	69,75	17beta-hydroxysteroid	AKR1C3	CHEBI:35343	8644	Chemical	Gene	F_synthase|amod|START_ENTITY F_synthase|appos|END_ENTITY	Type 5 17beta-hydroxysteroid dehydrogenase/prostaglandin _ F_synthase -LRB- AKR1C3 -RRB- : role in breast_cancer and inhibition by non-steroidal anti-inflammatory drug analogs .
19336506	0	17beta-hydroxysteroid	7,28	AKR1C3	44,50	17beta-hydroxysteroid	AKR1C3	CHEBI:35343	8644	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	Type 5 17beta-hydroxysteroid dehydrogenase -LRB- AKR1C3 -RRB- contributes to testosterone production in the adrenal_reticularis .
20661409	0	17beta-hydroxysteroid	46,67	AKR1C3	83,89	17beta-hydroxysteroid	AKR1C3	CHEBI:35343	8644	Chemical	Gene	dehydrogenase|amod|START_ENTITY expression|nmod|dehydrogenase expression|appos|END_ENTITY	Suppressed expression of type 2 3alpha/type 5 17beta-hydroxysteroid dehydrogenase -LRB- AKR1C3 -RRB- in endometrial_hyperplasia_and_carcinoma .
18669642	0	17beta-hydroxysteroid	38,59	Hsd17b7	87,94	17beta-hydroxysteroid	Hsd17b7	CHEBI:35343	15490(Tax:10090)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Prolactin_receptor-associated_protein / 17beta-hydroxysteroid dehydrogenase type 7 gene -LRB- Hsd17b7 -RRB- plays a crucial role in embryonic development and fetal survival .
19469652	0	17beta-hydroxysteroid	0,21	Pan1b	45,50	17beta-hydroxysteroid	Pan1b	CHEBI:35343	51170	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	17beta-hydroxysteroid dehydrogenase type 11 -LRB- Pan1b -RRB- expression in human prostate_cancer .
18669642	0	17beta-hydroxysteroid	38,59	Prolactin_receptor-associated_protein	0,37	17beta-hydroxysteroid	Prolactin receptor-associated protein	CHEBI:35343	20200(Tax:10090)	Chemical	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Prolactin_receptor-associated_protein / 17beta-hydroxysteroid dehydrogenase type 7 gene -LRB- Hsd17b7 -RRB- plays a crucial role in embryonic development and fetal survival .
17085046	0	17beta-hydroxysteroid	45,66	type_2	81,87	17beta-hydroxysteroid	type 2	CHEBI:35343	445471(Tax:7955)	Chemical	Gene	enzyme|amod|START_ENTITY enzyme|amod|END_ENTITY	Functional genome analysis indicates loss of 17beta-hydroxysteroid dehydrogenase type_2 enzyme in the zebrafish .
10583311	0	17beta-oestradiol	29,46	leptin	56,62	17beta-oestradiol	leptin	MESH:D004958	3952	Chemical	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	Effects of administration of 17beta-oestradiol on serum leptin levels in healthy postmenopausal women .
12697817	0	18-amino-acid	23,36	U1A	37,40	18-amino-acid	U1A	null	6626	Chemical	Gene	domain|amod|START_ENTITY domain|compound|END_ENTITY	Determinants within an 18-amino-acid U1A autoregulatory domain that uncouple cooperative RNA binding , inhibition of polyadenylation , and homodimerization .
479350	0	18-hydroxy-11-deoxycorticosterone	46,79	angiotensin_II	14,28	18-hydroxy-11-deoxycorticosterone	angiotensin II	MESH:D015070	183	Chemical	Gene	production|amod|START_ENTITY effect|nmod|production effect|nmod|END_ENTITY	The effect of angiotensin_II and saralasin on 18-hydroxy-11-deoxycorticosterone production by isolated human adrenal glomerulosa cells .
2545066	0	18-hydroxycorticosterone	7,31	angiotensin_II	61,75	18-hydroxycorticosterone	angiotensin II	MESH:D015069	183	Chemical	Gene	responses|amod|START_ENTITY responses|nmod|END_ENTITY	Plasma 18-hydroxycorticosterone and aldosterone responses to angiotensin_II and corticotropin in diabetic patients with hyporeninemic_and_normoreninemic_hypoaldosteronism .
2407571	0	18-hydroxycorticosterone	78,102	angiotensin_I_converting_enzyme	15,46	18-hydroxycorticosterone	angiotensin I converting enzyme	MESH:D015069	24310(Tax:10116)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	-LSB- The effect of angiotensin_I_converting_enzyme inhibitor -LRB- SQ_14225 -RRB- on plasma 18-hydroxycorticosterone and aldosterone in sodium depleted conscious rats -RSB- .
11549669	0	18-hydroxylated_steroids	11,35	aldosterone_synthase	74,94	18-hydroxylated steroids	aldosterone synthase	null	1585	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of 18-hydroxylated_steroids on corticosteroid production by human aldosterone_synthase and 11beta-hydroxylase .
12019193	0	18-methoxycoronaridine	14,36	CYP2C19	108,115	18-methoxycoronaridine	CYP2C19	MESH:C103345	1557	Chemical	Gene	Metabolism|nmod|START_ENTITY Metabolism|nmod|END_ENTITY	Metabolism of 18-methoxycoronaridine , an ibogaine analog , to 18-hydroxycoronaridine by genetically variable CYP2C19 .
2539538	0	18-oxocortisol	0,14	ACTH	41,45	18-oxocortisol	ACTH	MESH:C038135	5443	Chemical	Gene	START_ENTITY|dep|effect effect|nmod|END_ENTITY	18-oxocortisol : effect of dexamethasone , ACTH and sodium restriction .
26025960	0	18F-DPA-714	61,72	Translocator_Protein	28,48	18F-DPA-714	Translocator Protein	null	706	Chemical	Gene	Uptake|compound|START_ENTITY Uptake|compound|END_ENTITY	Optimized Quantification of Translocator_Protein Radioligand 18F-DPA-714 Uptake in the Brain of Genotyped Healthy Volunteers .
25214643	0	18F-FDG	55,62	Hypoxia-Inducible_Factor-1a	74,101	18F-FDG	Hypoxia-Inducible Factor-1a	MESH:D019788	3091	Chemical	Gene	Uptake|compound|START_ENTITY Uptake|nmod|Activation Activation|compound|END_ENTITY	Oxidized Low-Density Lipoprotein Stimulates Macrophage 18F-FDG Uptake via Hypoxia-Inducible_Factor-1a Activation Through Nox2-Dependent Reactive Oxygen Species Generation .
26850484	0	18F-Fluoroestradiol	87,106	Estrogen_Receptor	26,43	18F-Fluoroestradiol	Estrogen Receptor	null	2099	Chemical	Gene	Expression|amod|START_ENTITY Expression|compound|END_ENTITY	Temporal Heterogeneity of Estrogen_Receptor Expression in Bone-Dominant Breast Cancer : 18F-Fluoroestradiol PET Imaging Shows Return of ER Expression .
23354033	0	18F-fluorocholine	50,67	erythropoietin	10,24	18F-fluorocholine	erythropoietin	MESH:C514960	2056	Chemical	Gene	uptake|nmod|START_ENTITY END_ENTITY|nmod|uptake	Effect of erythropoietin on bone marrow uptake of 18F-fluorocholine in prostate_cancer : comparison with 18F-fluoride uptake .
2143753	0	18F-labeled_benzamide	41,62	dopamine_D2_receptor	84,104	18F-labeled benzamide	dopamine D2 receptor	null	1813	Chemical	Gene	analogs|amod|START_ENTITY analogs|nmod|END_ENTITY	Preparation and biological evaluation of 18F-labeled_benzamide analogs as potential dopamine_D2_receptor ligands .
24480780	0	18F-labeled_pyridinylphenyl_amides	31,65	dopamine_D3_receptor	108,128	18F-labeled pyridinylphenyl amides	dopamine D3 receptor	null	29238(Tax:10116)	Chemical	Gene	studies|nmod|START_ENTITY studies|nmod|END_ENTITY	Biodistribution studies of two 18F-labeled_pyridinylphenyl_amides as subtype selective radioligands for the dopamine_D3_receptor .
25973013	0	18a-glycyrrhizin	11,27	TGF-b1	31,37	18a-glycyrrhizin	TGF-b1	null	59086(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of 18a-glycyrrhizin on TGF-b1 / Smad signaling pathway in rats with carbon_tetrachloride-induced liver_fibrosis .
26010440	0	18b-Glycyrrhetic_Acid	42,63	Cytochrome_P450	14,29	18b-Glycyrrhetic Acid	Cytochrome P450	null	25251(Tax:10116)	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|Activity Activity|amod|END_ENTITY	Modulation of Cytochrome_P450 Activity by 18b-Glycyrrhetic_Acid and its Consequence on Buspirone Pharmacokinetics in Rats .
26010440	0	18b-Glycyrrhetic_Acid	42,63	Cytochrome_P450	14,29	18b-Glycyrrhetic Acid	Cytochrome P450	null	25251(Tax:10116)	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|Activity Activity|amod|END_ENTITY	Modulation of Cytochrome_P450 Activity by 18b-Glycyrrhetic_Acid and its Consequence on Buspirone Pharmacokinetics in Rats .
26121859	0	18b-glycyrrhetinic_Acid	12,35	CCL11	57,62	18b-glycyrrhetinic Acid	CCL11	null	29397(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of 18b-glycyrrhetinic_Acid on the Expression of CCL11 , AQP1 and EOS in Nasal Mucosa of Allergic_Rhinitis Rats -RSB- .
22865487	0	18b-glycyrrhetinic_acid	0,23	Hsp90	36,41	18b-glycyrrhetinic acid	Hsp90	null	3320	Chemical	Gene	potentiates|amod|START_ENTITY END_ENTITY|nsubj|potentiates	18b-glycyrrhetinic_acid potentiates Hsp90 inhibition-induced apoptosis in human epithelial_ovarian_carcinoma cells via activation of death receptor and mitochondrial pathway .
24261979	0	18b-glycyrrhetinic_acid	0,23	UDP-glucuronosyltransferase	32,59	18b-glycyrrhetinic acid	UDP-glucuronosyltransferase	null	24862(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	18b-glycyrrhetinic_acid induces UDP-glucuronosyltransferase in rats .
19638273	0	1H	58,60	Connexin_32	40,51	1H	Connexin 32	null	2705	Chemical	Gene	using|dobj|START_ENTITY END_ENTITY|acl|using	Structural studies of the N-terminus of Connexin_32 using 1H NMR spectroscopy .
7160490	0	1H	97,99	serotransferrin	75,90	1H	serotransferrin	null	7018	Chemical	Gene	using|dobj|START_ENTITY END_ENTITY|acl|using	Solution conformation of the biantennary N-linked oligosaccharide of human serotransferrin using 1H NMR nuclear Overhauser effect measurements .
3681891	0	1H-benzimidazol-4-ols	6,27	5-lipoxygenase	40,54	1H-benzimidazol-4-ols	5-lipoxygenase	null	25290(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Novel 1H-benzimidazol-4-ols with potent 5-lipoxygenase inhibitory activity .
25187680	0	1H-pyrazole	21,32	receptor_tyrosine_kinase	48,72	1H-pyrazole	receptor tyrosine kinase	CHEBI:17241	5979	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Molecular docking of 1H-pyrazole derivatives to receptor_tyrosine_kinase and protein kinase for screening potential inhibitors .
12834181	0	1alpha-hydroxyvitamin_D2	27,51	PTH	56,59	1alpha-hydroxyvitamin D2	PTH	MESH:C042533	5741	Chemical	Gene	Effect|dep|START_ENTITY Effect|nmod|END_ENTITY	Effect of doxercalciferol -LRB- 1alpha-hydroxyvitamin_D2 -RRB- on PTH , bone turnover and bone mineral density in a hemodialysis patient with persistent secondary_hyperparathyroidism post parathyroidectomy .
6464025	0	2,3,7,8-TCDD	78,90	AHH	119,122	2,3,7,8-TCDD	AHH	null	24296(Tax:10116)	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Polychlorinated dibenzofurans -LRB- PCDFs -RRB- : effects of structure on binding to the 2,3,7,8-TCDD cytosolic receptor protein , AHH induction and toxicity .
26377645	0	2,3,7,8-Tetrachlorodibenzo-p-Dioxin	64,99	AhR	4,7	2,3,7,8-Tetrachlorodibenzo-p-Dioxin	AhR	MESH:D013749	11622(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|dep|Effect	The AhR and NF-kB/Rel Proteins Mediate the Inhibitory Effect of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin on the 3 ' Immunoglobulin Heavy Chain Regulatory Region .
8293544	0	2,3,7,8-Tetrachlorodibenzo-p-dioxin	0,35	Ah_receptor	104,115	2,3,7,8-Tetrachlorodibenzo-p-dioxin	Ah receptor	MESH:D013749	11622(Tax:10090)	Chemical	Gene	modulator|amod|START_ENTITY hepatocytes|nsubj|modulator hepatocytes|nmod|END_ENTITY	2,3,7,8-Tetrachlorodibenzo-p-dioxin as growth modulator in mouse hepatocytes with high and low affinity Ah_receptor .
26495820	0	2,3,7,8-Tetrachlorodibenzo-p-dioxin	72,107	Aryl_Hydrocarbon_Receptor	43,68	2,3,7,8-Tetrachlorodibenzo-p-dioxin	Aryl Hydrocarbon Receptor	MESH:D013749	11622(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|Activation Activation|nmod|END_ENTITY	Effects of Developmental Activation of the Aryl_Hydrocarbon_Receptor by 2,3,7,8-Tetrachlorodibenzo-p-dioxin on Long-Term Self-Renewal of Murine Hematopoietic Stem Cells .
11500237	0	2,3,7,8-Tetrachlorodibenzo-p-dioxin	0,35	CYP1A1	100,106	2,3,7,8-Tetrachlorodibenzo-p-dioxin	CYP1A1	MESH:D013749	24296(Tax:10116)	Chemical	Gene	increases|amod|START_ENTITY steady-state|nsubj|increases steady-state|nmod|induction induction|compound|END_ENTITY	2,3,7,8-Tetrachlorodibenzo-p-dioxin increases steady-state estrogen receptor-beta mRNA levels after CYP1A1 and CYP1B1 induction in rat granulosa cells in vitro .
18558727	0	2,3,7,8-Tetrachlorodibenzo-p-dioxin	0,35	CYP1A1	200,206	2,3,7,8-Tetrachlorodibenzo-p-dioxin	CYP1A1	MESH:D013749	1543	Chemical	Gene	modulates|amod|START_ENTITY _|nsubj|modulates _|nmod|alteration alteration|nmod|expression expression|compound|END_ENTITY	2,3,7,8-Tetrachlorodibenzo-p-dioxin modulates the induction of DNA strand breaks and poly -LRB- ADP-ribose -RRB- _ polymerase-1 activation by 17beta-estradiol in human breast_carcinoma cells through alteration of CYP1A1 and CYP1B1 expression .
23700305	0	2,3,7,8-Tetrachlorodibenzo-p-dioxin	0,35	CYP1A1	137,143	2,3,7,8-Tetrachlorodibenzo-p-dioxin	CYP1A1	MESH:D013749	1543	Chemical	Gene	modulates|amod|START_ENTITY estradiol-induced|nsubj|modulates estradiol-induced|nmod|alteration alteration|nmod|expression expression|compound|END_ENTITY	2,3,7,8-Tetrachlorodibenzo-p-dioxin modulates estradiol-induced aldehydic DNA lesions in human breast_cancer cells through alteration of CYP1A1 and CYP1B1 expression .
20055451	0	2,3,7,8-Tetrachlorodibenzo-p-dioxin	0,35	FoxQ1b	48,54	2,3,7,8-Tetrachlorodibenzo-p-dioxin	FoxQ1b	MESH:D013749	405843(Tax:7955)	Chemical	Gene	upregulates|amod|START_ENTITY END_ENTITY|nsubj|upregulates	2,3,7,8-Tetrachlorodibenzo-p-dioxin upregulates FoxQ1b in zebrafish jaw primordium .
8545841	0	2,3,7,8-Tetrachlorodibenzo-p-dioxin	27,62	PEPCK	124,129	2,3,7,8-Tetrachlorodibenzo-p-dioxin	PEPCK	MESH:D013749	362282(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Tissue-specific effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- on the activity of phosphoenolpyruvate_carboxykinase -LRB- PEPCK -RRB- in rats .
714027	0	2,3,7,8-Tetrachlorodibenzo-p-dioxin	0,35	aryl_hydrocarbon_hydroxylase	49,77	2,3,7,8-Tetrachlorodibenzo-p-dioxin	aryl hydrocarbon hydroxylase	MESH:D013749	24296(Tax:10116)	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	2,3,7,8-Tetrachlorodibenzo-p-dioxin induction of aryl_hydrocarbon_hydroxylase in female rat liver .
18382861	0	2,3,7,8-Tetrachlorodibenzo-p-dioxin	0,35	aryl_hydrocarbon_receptor	165,190	2,3,7,8-Tetrachlorodibenzo-p-dioxin	aryl hydrocarbon receptor	MESH:D013749	11622(Tax:10090)	Chemical	Gene	alters|nsubj|START_ENTITY alters|nmod|mechanism mechanism|acl:relcl|dependent dependent|nmod|END_ENTITY	2,3,7,8-Tetrachlorodibenzo-p-dioxin alters the differentiation of alloreactive CD8 + T cells toward a regulatory T cell phenotype by a mechanism that is dependent on aryl_hydrocarbon_receptor in CD4 + T cells .
22483799	0	2,3,7,8-Tetrachlorodibenzo-p-dioxin	0,35	aryl_hydrocarbon_receptor	50,75	2,3,7,8-Tetrachlorodibenzo-p-dioxin	aryl hydrocarbon receptor	MESH:D013749	11622(Tax:10090)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|sex sex|compound|END_ENTITY	2,3,7,8-Tetrachlorodibenzo-p-dioxin activates the aryl_hydrocarbon_receptor and alters sex steroid hormone secretion without affecting growth of mouse antral follicles in vitro .
3266253	0	2,3,7,8-Tetrachlorodibenzo-p-dioxin	0,35	epidermal_growth_factor_receptor	90,122	2,3,7,8-Tetrachlorodibenzo-p-dioxin	epidermal growth factor receptor	MESH:D013749	24329(Tax:10116)	Chemical	Gene	causes|dep|START_ENTITY causes|nsubj|increase increase|nmod|kinases kinases|acl|associated associated|nmod|END_ENTITY	2,3,7,8-Tetrachlorodibenzo-p-dioxin causes an increase in protein kinases associated with epidermal_growth_factor_receptor in the hepatic plasma membrane .
15496506	0	2,3,7,8-Tetrachlorodibenzo-p-dioxin	0,35	insulin-like_growth_factor_binding_protein-1	44,88	2,3,7,8-Tetrachlorodibenzo-p-dioxin	insulin-like growth factor binding protein-1	MESH:D013749	3484	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	2,3,7,8-Tetrachlorodibenzo-p-dioxin induces insulin-like_growth_factor_binding_protein-1 gene expression and counteracts the negative effect of insulin .
8545841	0	2,3,7,8-Tetrachlorodibenzo-p-dioxin	27,62	phosphoenolpyruvate_carboxykinase	89,122	2,3,7,8-Tetrachlorodibenzo-p-dioxin	phosphoenolpyruvate carboxykinase	MESH:D013749	362282(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	Tissue-specific effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- on the activity of phosphoenolpyruvate_carboxykinase -LRB- PEPCK -RRB- in rats .
12111005	0	2,3,7,8-Tetrachlorodibenzo-p-dioxin	0,35	plasminogen_activator_inhibitor-1	51,84	2,3,7,8-Tetrachlorodibenzo-p-dioxin	plasminogen activator inhibitor-1	MESH:D013749	18787(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	2,3,7,8-Tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- induces plasminogen_activator_inhibitor-1 through an aryl_hydrocarbon_receptor-mediated pathway in mouse hepatoma cell lines .
15371557	0	2,3,7,8-Tetrachlorodibenzo-p-dioxin	0,35	suppressor_of_cytokine_signaling_2	44,78	2,3,7,8-Tetrachlorodibenzo-p-dioxin	suppressor of cytokine signaling 2	MESH:D013749	216233(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	2,3,7,8-Tetrachlorodibenzo-p-dioxin induces suppressor_of_cytokine_signaling_2 in murine B cells .
11707340	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	132,167	AHR	112,115	2,3,7,8-tetrachlorodibenzo-p-dioxin	AHR	MESH:D013749	196	Chemical	Gene	lack|xcomp|START_ENTITY lack|nsubj|receptor receptor|acl|homologue homologue|nmod|clam clam|appos|arenaria arenaria|dep|evidence evidence|acl:relcl|invertebrate invertebrate|dobj|homologues homologues|compound|END_ENTITY	An aryl_hydrocarbon receptor -LRB- AHR -RRB- homologue from the soft-shell clam , Mya arenaria : evidence that invertebrate AHR homologues lack 2,3,7,8-tetrachlorodibenzo-p-dioxin and beta-naphthoflavone binding .
11707340	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	132,167	AHR	30,33	2,3,7,8-tetrachlorodibenzo-p-dioxin	AHR	MESH:D013749	196	Chemical	Gene	lack|xcomp|START_ENTITY lack|nsubj|receptor receptor|appos|END_ENTITY	An aryl_hydrocarbon receptor -LRB- AHR -RRB- homologue from the soft-shell clam , Mya arenaria : evidence that invertebrate AHR homologues lack 2,3,7,8-tetrachlorodibenzo-p-dioxin and beta-naphthoflavone binding .
18163543	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	83,118	AH_receptor	22,33	2,3,7,8-tetrachlorodibenzo-p-dioxin	AH receptor	MESH:D013749	11622(Tax:10090)	Chemical	Gene	induced|advcl|START_ENTITY induced|nsubj|role role|nmod|END_ENTITY	Essential role of the AH_receptor in the dysfunction of heme metabolism induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin .
18657588	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	10,45	AH_receptor	180,191	2,3,7,8-tetrachlorodibenzo-p-dioxin	AH receptor	MESH:D013749	25690(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY synthetase|nsubj|Effect synthetase|nmod|rats rats|nmod|END_ENTITY	Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- on heme_oxygenase-1 , biliverdin_IXalpha_reductase and delta-aminolevulinic_acid synthetase 1 in rats with wild-type or variant AH_receptor .
9514084	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	119,154	AH_receptor	23,34	2,3,7,8-tetrachlorodibenzo-p-dioxin	AH receptor	MESH:D013749	11622(Tax:10090)	Chemical	Gene	depletion|nmod|START_ENTITY depletion|nmod|END_ENTITY	Prolonged depletion of AH_receptor without alteration of receptor mRNA levels after treatment of cells in culture with 2,3,7,8-tetrachlorodibenzo-p-dioxin .
11048681	10	2,3,7,8-tetrachlorodibenzo-p-dioxin	1386,1421	AhR	1463,1466	2,3,7,8-tetrachlorodibenzo-p-dioxin	AhR	MESH:D013749	373907(Tax:9031)	Chemical	Gene	induced|nmod|START_ENTITY induced|nmod|subset subset|nmod|tissues tissues|acl|expressing expressing|dobj|END_ENTITY	Cytochrome_P4501A4 mRNA was highly induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- in a subset of tissues expressing AhR , including small intestine , liver , kidney , blood vessels , and outflow tract myocardium .
11243847	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	106,141	AhR	27,30	2,3,7,8-tetrachlorodibenzo-p-dioxin	AhR	MESH:D013749	11622(Tax:10090)	Chemical	Gene	xanthine_dehydrogenase|advcl|START_ENTITY xanthine_dehydrogenase|nsubj|receptor receptor|appos|END_ENTITY	Aryl_hydrocarbon receptor -LRB- AhR -RRB- - mediated induction of xanthine_oxidase / xanthine_dehydrogenase activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin .
11453109	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	91,126	AhR	27,30	2,3,7,8-tetrachlorodibenzo-p-dioxin	AhR	MESH:D013749	196	Chemical	Gene	cells|amod|START_ENTITY inhibition|nmod|cells receptor|dep|inhibition receptor|appos|END_ENTITY	Aryl_hydrocarbon receptor -LRB- AhR -RRB- - linked inhibition of luteal cell progesterone secretion in 2,3,7,8-tetrachlorodibenzo-p-dioxin treated cells .
12490139	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	79,114	AhR	123,126	2,3,7,8-tetrachlorodibenzo-p-dioxin	AhR	MESH:D013749	11622(Tax:10090)	Chemical	Gene	targets|nmod|START_ENTITY aryl_hydrocarbon_receptor|dep|targets aryl_hydrocarbon_receptor|dep|expression expression|compound|END_ENTITY	T lymphocytes are direct , aryl_hydrocarbon_receptor -LRB- AhR -RRB- - dependent targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- : AhR expression in both CD4 + and CD8 + T cells is necessary for full suppression of a cytotoxic T lymphocyte response by TCDD .
12490139	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	79,114	AhR	53,56	2,3,7,8-tetrachlorodibenzo-p-dioxin	AhR	MESH:D013749	11622(Tax:10090)	Chemical	Gene	targets|nmod|START_ENTITY aryl_hydrocarbon_receptor|dep|targets aryl_hydrocarbon_receptor|appos|END_ENTITY	T lymphocytes are direct , aryl_hydrocarbon_receptor -LRB- AhR -RRB- - dependent targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- : AhR expression in both CD4 + and CD8 + T cells is necessary for full suppression of a cytotoxic T lymphocyte response by TCDD .
12738279	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	78,113	AhR	51,54	2,3,7,8-tetrachlorodibenzo-p-dioxin	AhR	MESH:D013749	11622(Tax:10090)	Chemical	Gene	cells|nmod|START_ENTITY activation|nmod|cells activation|appos|END_ENTITY	Functional activation of arylhydrocarbon_receptor -LRB- AhR -RRB- in primary T cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin .
12758056	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	68,103	AhR	0,3	2,3,7,8-tetrachlorodibenzo-p-dioxin	AhR	MESH:D013749	11622(Tax:10090)	Chemical	Gene	suppression|amod|START_ENTITY mediate|dobj|suppression function|xcomp|mediate function|nsubj|pathways pathways|amod|END_ENTITY	AhR - and ERK-dependent pathways function synergistically to mediate 2,3,7,8-tetrachlorodibenzo-p-dioxin suppression of peroxisome proliferator-activated receptor-gamma1 expression and subsequent adipocyte differentiation .
14510636	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	54,89	AhR	244,247	2,3,7,8-tetrachlorodibenzo-p-dioxin	AhR	MESH:D013749	11622(Tax:10090)	Chemical	Gene	oxidoreductase|nmod|START_ENTITY H|dep|oxidoreductase Induction|nmod|H requires|nsubj|Induction requires|dobj|CNC CNC|dep|Nrf2 Nrf2|dep|cross-interaction cross-interaction|nmod|END_ENTITY	Induction of murine NAD -LRB- P -RRB- H : quinone oxidoreductase by 2,3,7,8-tetrachlorodibenzo-p-dioxin requires the CNC -LRB- cap 'n' collar -RRB- basic leucine zipper transcription factor Nrf2 -LRB- nuclear_factor_erythroid_2-related_factor_2 -RRB- : cross-interaction between AhR -LRB- aryl_hydrocarbon_receptor -RRB- and Nrf2 signal transduction .
15533795	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	55,90	AhR	27,30	2,3,7,8-tetrachlorodibenzo-p-dioxin	AhR	MESH:D013749	196	Chemical	Gene	effects|nmod|START_ENTITY receptor|dep|effects receptor|appos|END_ENTITY	Aryl_hydrocarbon receptor -LRB- AhR -RRB- - independent effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- on softshell clam -LRB- Mya arenaria -RRB- reproductive tissue .
16891777	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	27,62	AhR	90,93	2,3,7,8-tetrachlorodibenzo-p-dioxin	AhR	MESH:D013749	11622(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|liver liver|nmod|wild-type wild-type|appos|+ +|compound|END_ENTITY	Gene expression profile by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the liver of wild-type -LRB- AhR + / + -RRB- and aryl_hydrocarbon_receptor-deficient -LRB- AhR - / - -RRB- mice .
18487412	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	91,126	AhR	39,42	2,3,7,8-tetrachlorodibenzo-p-dioxin	AhR	MESH:D013749	11622(Tax:10090)	Chemical	Gene	shift|advcl|START_ENTITY shift|nsubj|rhythmicity rhythmicity|nmod|mice mice|acl|lacking lacking|dobj|END_ENTITY	Behavioral rhythmicity of mice lacking AhR and attenuation of light-induced phase shift by 2,3,7,8-tetrachlorodibenzo-p-dioxin .
19018768	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	61,96	AhR	126,129	2,3,7,8-tetrachlorodibenzo-p-dioxin	AhR	MESH:D013749	196	Chemical	Gene	response|nmod|START_ENTITY induction|nmod|response attenuates|dobj|induction attenuates|nmod|END_ENTITY	Curcumin attenuates cytochrome P450 induction in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin by ROS-dependently degrading AhR and ARNT .
25867478	6	2,3,7,8-tetrachlorodibenzo-p-dioxin	823,858	AhR	810,813	2,3,7,8-tetrachlorodibenzo-p-dioxin	AhR	MESH:D013749	196	Chemical	Gene	agonist|amod|START_ENTITY agonist|compound|END_ENTITY	The AhR agonist , 2,3,7,8-tetrachlorodibenzo-p-dioxin , did not affect bone growth at any concentrations tested -LRB- 1 pM-10 nM -RRB- .
14594946	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	114,149	Ah_receptor	76,87	2,3,7,8-tetrachlorodibenzo-p-dioxin	Ah receptor	MESH:D013749	196	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|Suppression Suppression|nmod|inhibitors inhibitors|nmod|END_ENTITY	Suppression by p38 MAP kinase inhibitors -LRB- pyridinyl_imidazole compounds -RRB- of Ah_receptor target gene activation by 2,3,7,8-tetrachlorodibenzo-p-dioxin and the possible mechanism .
15659807	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	44,79	Ah_receptor	198,209	2,3,7,8-tetrachlorodibenzo-p-dioxin	Ah receptor	MESH:D013749	196	Chemical	Gene	induction|nmod|START_ENTITY SB203580|nmod|induction Blockade|nmod|SB203580 Blockade|dep|involvement involvement|nmod|pathway pathway|acl|shuttling shuttling|nmod|END_ENTITY	Blockade by SB203580 of Cyp1a1 induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin , and the possible mechanism : possible involvement of the p38_mitogen-activated_protein_kinase pathway in shuttling of Ah_receptor overexpressed in COS-7 cells .
2160139	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	97,132	Ah_receptor	177,188	2,3,7,8-tetrachlorodibenzo-p-dioxin	Ah receptor	MESH:D013749	25690(Tax:10116)	Chemical	Gene	components|amod|START_ENTITY components|amod|distinct distinct|nmod|END_ENTITY	Chemically_induced hepatic cytosol from the Sprague-Dawley_rat : evidence for specific binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin to components kinetically distinct from the Ah_receptor .
2550120	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	77,112	Ah_receptor	0,11	2,3,7,8-tetrachlorodibenzo-p-dioxin	Ah receptor	MESH:D013749	11622(Tax:10090)	Chemical	Gene	binding|nmod|START_ENTITY detection|nmod|binding END_ENTITY|dep|detection	Ah_receptor in spleen of rodent and primate species : detection by binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin .
2833345	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	82,117	Ah_receptor	24,35	2,3,7,8-tetrachlorodibenzo-p-dioxin	Ah receptor	MESH:D013749	196	Chemical	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	Characterization of the Ah_receptor and aryl_hydrocarbon_hydroxylase induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin and benz -LRB- a -RRB- anthracene in the human A431_squamous_cell_carcinoma line .
2848187	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	32,67	Ah_receptor	95,106	2,3,7,8-tetrachlorodibenzo-p-dioxin	Ah receptor	MESH:D013749	11622(Tax:10090)	Chemical	Gene	ligands|amod|START_ENTITY ligands|nmod|END_ENTITY	A competitive binding assay for 2,3,7,8-tetrachlorodibenzo-p-dioxin and related ligands of the Ah_receptor .
2850772	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	116,151	Ah_receptor	56,67	2,3,7,8-tetrachlorodibenzo-p-dioxin	Ah receptor	MESH:D013749	11622(Tax:10090)	Chemical	Gene	exposed|nmod|START_ENTITY exposed|nsubj|characterization characterization|nmod|form form|nmod|END_ENTITY	Physicochemical characterization of the nuclear form of Ah_receptor from mouse hepatoma cells exposed in culture to 2,3,7,8-tetrachlorodibenzo-p-dioxin .
3019582	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	71,106	Ah_receptor	32,43	2,3,7,8-tetrachlorodibenzo-p-dioxin	Ah receptor	MESH:D013749	25690(Tax:10116)	Chemical	Gene	inducibility|nmod|START_ENTITY inducibility|compound|END_ENTITY	Effects of thyroidectomy on the Ah_receptor and enzyme inducibility by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat liver .
3028264	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	85,120	Ah_receptor	30,41	2,3,7,8-tetrachlorodibenzo-p-dioxin	Ah receptor	MESH:D013749	25690(Tax:10116)	Chemical	Gene	cytosolic|amod|START_ENTITY receptor|amod|cytosolic binding|nmod|receptor required|nmod|binding groups|acl|required Structure|dep|groups Structure|nmod|END_ENTITY	Structure and function of the Ah_receptor : sulfhydryl groups required for binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin to cytosolic receptor from rodent livers .
3040108	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	53,88	Ah_receptor	132,143	2,3,7,8-tetrachlorodibenzo-p-dioxin	Ah receptor	MESH:D013749	25690(Tax:10116)	Chemical	Gene	inhibitors|nmod|START_ENTITY Influence|nmod|inhibitors Influence|dep|capacity capacity|nmod|END_ENTITY	Influence of proteinase inhibitors and substrates on 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- - binding capacity of the rat hepatic Ah_receptor .
3040233	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	93,128	Ah_receptor	0,11	2,3,7,8-tetrachlorodibenzo-p-dioxin	Ah receptor	MESH:D013749	196	Chemical	Gene	binding|nmod|START_ENTITY pyrene|amod|binding stabilization|nmod|pyrene END_ENTITY|dep|stabilization	Ah_receptor in human placenta : stabilization by molybdate and characterization of binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin , 3-methylcholanthrene , and benzo -LRB- a -RRB- pyrene .
7992318	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	45,80	Ah_receptor	158,169	2,3,7,8-tetrachlorodibenzo-p-dioxin	Ah receptor	MESH:D013749	11622(Tax:10090)	Chemical	Gene	PCBs|amod|START_ENTITY communication|nmod|PCBs Inhibition|nmod|communication Inhibition|dep|involvement involvement|nmod|END_ENTITY	Inhibition of intercellular communication by 2,3,7,8-tetrachlorodibenzo-p-dioxin and dioxin-like PCBs in mouse hepatoma cells -LRB- Hepa1c1c7 -RRB- : involvement of the Ah_receptor .
9653054	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	59,94	Ah_receptor	105,116	2,3,7,8-tetrachlorodibenzo-p-dioxin	Ah receptor	MESH:D013749	25690(Tax:10116)	Chemical	Gene	exposure|amod|START_ENTITY tract|nmod|exposure Responsiveness|nmod|tract Responsiveness|dep|expression expression|compound|END_ENTITY	Responsiveness of the adult male rat reproductive tract to 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure : Ah_receptor and ARNT expression , CYP1A1 induction , and Ah_receptor down-regulation .
17949883	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	15,50	Ahr	124,127	2,3,7,8-tetrachlorodibenzo-p-dioxin	Ahr	MESH:D013749	11622(Tax:10090)	Chemical	Gene	traits|amod|START_ENTITY effects|nmod|traits effects|dep|test test|nmod|role role|nmod|locus locus|compound|END_ENTITY	The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on molar and mandible traits in congenic mice : a test of the role of the Ahr locus .
10053167	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	153,188	CYP1A1	47,53	2,3,7,8-tetrachlorodibenzo-p-dioxin	CYP1A1	MESH:D013749	24296(Tax:10116)	Chemical	Gene	presence|nmod|START_ENTITY incubated|nmod|presence incubated|nsubj|induction induction|nmod|END_ENTITY	Time - and concentration-dependent induction of CYP1A1 and CYP1A2 in precision-cut rat liver slices incubated in dynamic organ culture in the presence of 2,3,7,8-tetrachlorodibenzo-p-dioxin .
11281733	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	23,58	CYP1A1	156,162	2,3,7,8-tetrachlorodibenzo-p-dioxin	CYP1A1	MESH:D013749	1543	Chemical	Gene	cells|amod|START_ENTITY effects|nmod|cells steroid|nsubj|effects steroid|nmod|induction induction|compound|END_ENTITY	Comparative effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on MCF-7 , RL95-2 , and LNCaP cells : role of target steroid hormones in cellular responsiveness to CYP1A1 induction .
11728381	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	15,50	CYP1A1	67,73	2,3,7,8-tetrachlorodibenzo-p-dioxin	CYP1A1	MESH:D013749	1543	Chemical	Gene	Suppression|nmod|START_ENTITY Suppression|dep|END_ENTITY	Suppression of 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- - mediated CYP1A1 and CYP1B1 induction by 12-O-tetradecanoylphorbol-13-acetate : role of transforming_growth_factor_beta and mitogen-activated protein kinases .
12093619	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	76,111	CYP1A1	58,64	2,3,7,8-tetrachlorodibenzo-p-dioxin	CYP1A1	MESH:D013749	13076(Tax:10090)	Chemical	Gene	line|amod|START_ENTITY induced|nmod|line END_ENTITY|acl|induced	Estradiol enhances and estriol inhibits the expression of CYP1A1 induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in a mouse ovarian_cancer cell line .
15535986	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	22,57	CYP1A1	101,107	2,3,7,8-tetrachlorodibenzo-p-dioxin	CYP1A1	MESH:D013749	13076(Tax:10090)	Chemical	Gene	antagonism|nmod|START_ENTITY Lack|nmod|antagonism induction|nsubj|Lack induction|nmod|cytochrome_P4501A1 cytochrome_P4501A1|appos|END_ENTITY	Lack of antagonism of 2,3,7,8-tetrachlorodibenzo-p-dioxin 's -LRB- TCDDs -RRB- induction of cytochrome_P4501A1 -LRB- CYP1A1 -RRB- by the putative selective aryl_hydrocarbon_receptor modulator 6-alkyl-1 ,3,8 - trichlorodibenzofuran -LRB- 6-MCDF -RRB- in the mouse hepatoma cell line Hepa-1c1c7 .
15630080	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	43,78	CYP1A1	23,29	2,3,7,8-tetrachlorodibenzo-p-dioxin	CYP1A1	MESH:D013749	13076(Tax:10090)	Chemical	Gene	induction|nmod|START_ENTITY induction|nummod|END_ENTITY	Arsenite inhibition of CYP1A1 induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin is independent of cell cycle arrest .
1596902	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	52,87	CYP1A1	161,167	2,3,7,8-tetrachlorodibenzo-p-dioxin	CYP1A1	MESH:D013749	24296(Tax:10116)	Chemical	Gene	model|amod|START_ENTITY exposure|nmod|model relationships|nmod|exposure relationships|dep|quantification quantification|nmod|END_ENTITY	Dose-response relationships for chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in a rat tumor promotion model : quantification and immunolocalization of CYP1A1 and CYP1A2 in the liver .
16788090	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	33,68	CYP1A1	18,24	2,3,7,8-tetrachlorodibenzo-p-dioxin	CYP1A1	MESH:D013749	1543	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Regulation of the CYP1A1 gene by 2,3,7,8-tetrachlorodibenzo-p-dioxin but not by beta-naphthoflavone or 3-methylcholanthrene is altered in hepatitis_C virus replicon-expressing cells .
16839655	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	18,53	CYP1A1	69,75	2,3,7,8-tetrachlorodibenzo-p-dioxin	CYP1A1	MESH:D013749	13076(Tax:10090)	Chemical	Gene	Comparison|nmod|START_ENTITY Comparison|dep|profile profile|compound|END_ENTITY	Comparison of the 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- - induced CYP1A1 gene expression profile in lymphocytes from mice , rats , and humans : most potent induction in humans .
17624648	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	114,149	CYP1A1	37,43	2,3,7,8-tetrachlorodibenzo-p-dioxin	CYP1A1	MESH:D013749	24296(Tax:10116)	Chemical	Gene	exposed|nmod|START_ENTITY exposed|nsubj|expression expression|nummod|END_ENTITY	Panax_ginseng effects on DNA damage , CYP1A1 expression and histopathological changes in testes of rats exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin .
20705892	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	63,98	CYP1A1	33,39	2,3,7,8-tetrachlorodibenzo-p-dioxin	CYP1A1	MESH:D013749	24296(Tax:10116)	Chemical	Gene	induction|advcl|START_ENTITY induction|nsubj|END_ENTITY	Human and rat primary hepatocyte CYP1A1 and 1A2 induction with 2,3,7,8-tetrachlorodibenzo-p-dioxin , 2,3,7,8-tetrachlorodibenzofuran , and 2,3,4,7,8-pentachlorodibenzofuran .
22813907	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	145,180	CYP1A1	205,211	2,3,7,8-tetrachlorodibenzo-p-dioxin	CYP1A1	MESH:D013749	24296(Tax:10116)	Chemical	Gene	1,2,3,5,6,7-hexachloronaphthalene|acl|START_ENTITY toxicity|nmod|1,2,3,5,6,7-hexachloronaphthalene toxicity|nmod|END_ENTITY	Repeated dose toxicity and relative potency of 1,2,3,4,6,7-hexachloronaphthalene -LRB- PCN_66 -RRB- 1,2,3,5,6,7-hexachloronaphthalene -LRB- PCN_67 -RRB- compared to 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- for induction of CYP1A1 , CYP1A2 and thymic atrophy in female Harlan Sprague-Dawley_rats .
23997114	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	115,150	CYP1A1	105,111	2,3,7,8-tetrachlorodibenzo-p-dioxin	CYP1A1	MESH:D013749	13076(Tax:10090)	Chemical	Gene	necessary|advcl|START_ENTITY necessary|nmod|induction induction|nmod|END_ENTITY	Genome-wide RNAi high-throughput screen identifies proteins necessary for the AHR-dependent induction of CYP1A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin .
7687806	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	41,76	CYP1A1	26,32	2,3,7,8-tetrachlorodibenzo-p-dioxin	CYP1A1	MESH:D013749	1543	Chemical	Gene	inducer|xcomp|START_ENTITY inducer|nsubj|effect effect|nmod|END_ENTITY	Stimulatory effect of the CYP1A1 inducer 2,3,7,8-tetrachlorodibenzo-p-dioxin on the reproduction of HIV-1 in human lymphoid cell culture .
8291065	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	69,104	CYP1A1	106,112	2,3,7,8-tetrachlorodibenzo-p-dioxin	CYP1A1	MESH:D013749	13076(Tax:10090)	Chemical	Gene	exposure|nmod|START_ENTITY mice|nmod|exposure relationships|nmod|mice relationships|dep|END_ENTITY	Dose-response relationships in mice following subchronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin : CYP1A1 , CYP1A2 , estrogen receptor , and protein tyrosine phosphorylation .
8382112	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	71,106	CYP1A1	45,51	2,3,7,8-tetrachlorodibenzo-p-dioxin	CYP1A1	MESH:D013749	1543	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Effects of cycloheximide on the induction of CYP1A1 gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- in three human breast_cancer cell lines .
8396892	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	89,124	CYP1A1	16,22	2,3,7,8-tetrachlorodibenzo-p-dioxin	CYP1A1	MESH:D013749	1543	Chemical	Gene	cotreated|advcl|START_ENTITY cotreated|nsubj|Potentiation Potentiation|nmod|expression expression|compound|END_ENTITY	Potentiation of CYP1A1 gene expression in MCF-7 human breast_cancer cells cotreated with 2,3,7,8-tetrachlorodibenzo-p-dioxin and 12-O-tetradecanoylphorbol-13-acetate .
9195019	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	21,56	CYP1A1	153,159	2,3,7,8-tetrachlorodibenzo-p-dioxin	CYP1A1	MESH:D013749	13076(Tax:10090)	Chemical	Gene	exposure|amod|START_ENTITY Effect|nmod|exposure Effect|dep|calculation calculation|nmod|doses doses|nmod|activities activities|compound|END_ENTITY	Effect of subchronic 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on immune system and target gene responses in mice : calculation of benchmark doses for CYP1A1 and CYP1A2 related enzyme activities .
15953582	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	0,35	CYP1B1	44,50	2,3,7,8-tetrachlorodibenzo-p-dioxin	CYP1B1	MESH:D013749	1545	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nummod|END_ENTITY	2,3,7,8-tetrachlorodibenzo-p-dioxin induces CYP1B1 expression in human luteinized granulosa cells .
21509788	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	18,53	Cxcl4	96,101	2,3,7,8-tetrachlorodibenzo-p-dioxin	Cxcl4	MESH:D013749	56744(Tax:10090)	Chemical	Gene	exposure|nmod|START_ENTITY induces|nsubj|exposure induces|dobj|expression expression|nmod|END_ENTITY	Fetal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin induces expression of the chemokine genes Cxcl4 and Cxcl7 in the perinatal mouse brain .
10799651	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	14,49	Cyp1a1	68,74	2,3,7,8-tetrachlorodibenzo-p-dioxin	Cyp1a1	MESH:D013749	13076(Tax:10090)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|acl|stimulated stimulated|dobj|activity activity|amod|END_ENTITY	Inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- - stimulated Cyp1a1 promoter activity by hypoxic agents .
15659807	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	44,79	Cyp1a1	24,30	2,3,7,8-tetrachlorodibenzo-p-dioxin	Cyp1a1	MESH:D013749	1543	Chemical	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Blockade by SB203580 of Cyp1a1 induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin , and the possible mechanism : possible involvement of the p38_mitogen-activated_protein_kinase pathway in shuttling of Ah_receptor overexpressed in COS-7 cells .
15356078	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	98,133	Insulin	0,7	2,3,7,8-tetrachlorodibenzo-p-dioxin	Insulin	MESH:D013749	3630	Chemical	Gene	sensitivity|nmod|START_ENTITY sensitivity|compound|END_ENTITY	Insulin sensitivity following agent orange exposure in Vietnam veterans with high blood levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin .
21846477	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	22,57	Nrf2	0,4	2,3,7,8-tetrachlorodibenzo-p-dioxin	Nrf2	MESH:D013749	18024(Tax:10090)	Chemical	Gene	protects|nmod|START_ENTITY protects|nsubj|END_ENTITY	Nrf2 protects against 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- - induced oxidative injury and steatohepatitis .
9368027	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	75,110	Q1b	52,55	2,3,7,8-tetrachlorodibenzo-p-dioxin	Q1b	MESH:D013749	15006(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Down-regulation of major histocompatibility complex Q1b gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin .
18467041	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	34,69	TGF-beta1	9,18	2,3,7,8-tetrachlorodibenzo-p-dioxin	TGF-beta1	MESH:D013749	21803(Tax:10090)	Chemical	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	Enhanced TGF-beta1 is involved in 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- induced oxidative stress in C57BL/6 mouse testis .
9067482	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	15,50	TNF	84,87	2,3,7,8-tetrachlorodibenzo-p-dioxin	TNF	MESH:D013749	21926(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|production production|appos|END_ENTITY	The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- on tumor_necrosis_factor -LRB- TNF -RRB- production by peritoneal cells .
7974484	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	13,48	TNF-alpha	59,68	2,3,7,8-tetrachlorodibenzo-p-dioxin	TNF-alpha	MESH:D013749	21926(Tax:10090)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|levels levels|amod|END_ENTITY	Influence of 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- on TNF-alpha levels in the skin of congenic haired and hairless mice .
11408608	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	62,97	adseverin	33,42	2,3,7,8-tetrachlorodibenzo-p-dioxin	adseverin	MESH:D013749	20259(Tax:10090)	Chemical	Gene	up-regulation|nmod|START_ENTITY up-regulation|nmod|expression expression|amod|END_ENTITY	Immune-specific up-regulation of adseverin gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin .
2219118	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	90,125	aryl_hydrocarbon_hydroxylase	33,61	2,3,7,8-tetrachlorodibenzo-p-dioxin	aryl hydrocarbon hydroxylase	MESH:D013749	13076(Tax:10090)	Chemical	Gene	congeners|amod|START_ENTITY mice|nmod|congeners activity|nmod|mice activity|amod|END_ENTITY	Structure-dependent induction of aryl_hydrocarbon_hydroxylase activity in C57BL/6 mice by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related congeners : mechanistic studies .
2546564	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	95,130	aryl_hydrocarbon_hydroxylase	13,41	2,3,7,8-tetrachlorodibenzo-p-dioxin	aryl hydrocarbon hydroxylase	MESH:D013749	1544	Chemical	Gene	lines|amod|START_ENTITY receptor|nmod|lines Induction|nmod|receptor Induction|nmod|END_ENTITY	Induction of aryl_hydrocarbon_hydroxylase and demonstration of a specific nuclear receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in two human hepatoma cell lines .
2845603	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	91,126	aryl_hydrocarbon_hydroxylase	29,57	2,3,7,8-tetrachlorodibenzo-p-dioxin	aryl hydrocarbon hydroxylase	MESH:D013749	24296(Tax:10116)	Chemical	Gene	equivalents|amod|START_ENTITY determining|dobj|equivalents assay|advcl|determining assay|nsubj|Applications Applications|nmod|induction induction|compound|END_ENTITY	Applications of the in vitro aryl_hydrocarbon_hydroxylase induction assay for determining `` 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents '' : pyrolyzed brominated flame_retardants .
6857677	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	29,64	aryl_hydrocarbon_hydroxylase	130,158	2,3,7,8-tetrachlorodibenzo-p-dioxin	aryl hydrocarbon hydroxylase	MESH:D013749	13076(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Immunosuppressive effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin in strains of mice with different susceptibility to induction of aryl_hydrocarbon_hydroxylase .
7441519	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	81,116	aryl_hydrocarbon_hydroxylase	13,41	2,3,7,8-tetrachlorodibenzo-p-dioxin	aryl hydrocarbon hydroxylase	MESH:D013749	24296(Tax:10116)	Chemical	Gene	glands|advcl|START_ENTITY glands|nsubj|Induction Induction|nmod|activity activity|amod|END_ENTITY	Induction of aryl_hydrocarbon_hydroxylase activity in the rat prostate glands by 2,3,7,8-tetrachlorodibenzo-p-dioxin .
10860871	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	125,160	aryl_hydrocarbon_receptor	4,29	2,3,7,8-tetrachlorodibenzo-p-dioxin	aryl hydrocarbon receptor	MESH:D013749	11622(Tax:10090)	Chemical	Gene	has|nmod|START_ENTITY has|nsubj|END_ENTITY	The aryl_hydrocarbon_receptor has a role in the in vivo maturation of murine bone marrow B lymphocytes and their response to 2,3,7,8-tetrachlorodibenzo-p-dioxin .
10927021	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	15,50	aryl_hydrocarbon_receptor	67,92	2,3,7,8-tetrachlorodibenzo-p-dioxin	aryl hydrocarbon receptor	MESH:D013749	196	Chemical	Gene	Suppression|nmod|START_ENTITY Suppression|dep|transformation transformation|compound|END_ENTITY	Suppression of 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- - mediated aryl_hydrocarbon_receptor transformation and CYP1A1 induction by the phosphatidylinositol 3-kinase inhibitor 2 - -LRB- 4-morpholinyl -RRB- -8 - phenyl-4H-1 - _ benzopyran-4-one -LRB- LY294002 -RRB- .
11006360	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	26,61	aryl_hydrocarbon_receptor	100,125	2,3,7,8-tetrachlorodibenzo-p-dioxin	aryl hydrocarbon receptor	MESH:D013749	11622(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|role role|nmod|END_ENTITY	Antiestrogenic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin in mouse uterus : critical role of the aryl_hydrocarbon_receptor in stromal tissue .
11509025	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	21,56	aryl_hydrocarbon_receptor	77,102	2,3,7,8-tetrachlorodibenzo-p-dioxin	aryl hydrocarbon receptor	MESH:D013749	25690(Tax:10116)	Chemical	Gene	exposure|amod|START_ENTITY exposure|dep|effect effect|nmod|expression expression|compound|END_ENTITY	Persistent , low-dose 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure : effect on aryl_hydrocarbon_receptor expression in a dioxin-resistance model .
11755109	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	65,100	aryl_hydrocarbon_receptor	25,50	2,3,7,8-tetrachlorodibenzo-p-dioxin	aryl hydrocarbon receptor	MESH:D013749	25690(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|nsubj|up-regulation up-regulation|nmod|END_ENTITY	In vivo up-regulation of aryl_hydrocarbon_receptor expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- in a dioxin-resistant rat model .
12490139	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	79,114	aryl_hydrocarbon_receptor	26,51	2,3,7,8-tetrachlorodibenzo-p-dioxin	aryl hydrocarbon receptor	MESH:D013749	11622(Tax:10090)	Chemical	Gene	targets|nmod|START_ENTITY END_ENTITY|dep|targets	T lymphocytes are direct , aryl_hydrocarbon_receptor -LRB- AhR -RRB- - dependent targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- : AhR expression in both CD4 + and CD8 + T cells is necessary for full suppression of a cytotoxic T lymphocyte response by TCDD .
12621046	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	14,49	aryl_hydrocarbon_receptor	162,187	2,3,7,8-tetrachlorodibenzo-p-dioxin	aryl hydrocarbon receptor	MESH:D013749	11622(Tax:10090)	Chemical	Gene	toxicity|amod|START_ENTITY Resistance|nmod|toxicity Resistance|acl|carrying carrying|dobj|mutation mutation|nmod|sequence sequence|nmod|END_ENTITY	Resistance to 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity and abnormal liver development in mice carrying a mutation in the nuclear localization sequence of the aryl_hydrocarbon_receptor .
1322109	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	163,198	aryl_hydrocarbon_receptor	43,68	2,3,7,8-tetrachlorodibenzo-p-dioxin	aryl hydrocarbon receptor	MESH:D013749	25690(Tax:10116)	Chemical	Gene	antagonists|nmod|START_ENTITY required|parataxis|antagonists required|nmod|transformation transformation|compound|END_ENTITY	Chelatable metal ions are not required for aryl_hydrocarbon_receptor transformation to a DNA binding form : phenanthrolines are possible competitive antagonists of 2,3,7,8-tetrachlorodibenzo-p-dioxin .
14510636	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	54,89	aryl_hydrocarbon_receptor	249,274	2,3,7,8-tetrachlorodibenzo-p-dioxin	aryl hydrocarbon receptor	MESH:D013749	11622(Tax:10090)	Chemical	Gene	oxidoreductase|nmod|START_ENTITY H|dep|oxidoreductase Induction|nmod|H requires|nsubj|Induction requires|dobj|CNC CNC|dep|Nrf2 Nrf2|appos|END_ENTITY	Induction of murine NAD -LRB- P -RRB- H : quinone oxidoreductase by 2,3,7,8-tetrachlorodibenzo-p-dioxin requires the CNC -LRB- cap 'n' collar -RRB- basic leucine zipper transcription factor Nrf2 -LRB- nuclear_factor_erythroid_2-related_factor_2 -RRB- : cross-interaction between AhR -LRB- aryl_hydrocarbon_receptor -RRB- and Nrf2 signal transduction .
14729655	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	117,152	aryl_hydrocarbon_receptor	46,71	2,3,7,8-tetrachlorodibenzo-p-dioxin	aryl hydrocarbon receptor	MESH:D013749	196	Chemical	Gene	induced|advcl|START_ENTITY transduction|acl|induced inhibits|dobj|transduction END_ENTITY|acl:relcl|inhibits	The drug salicylamide is an antagonist of the aryl_hydrocarbon_receptor that inhibits signal transduction induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin .
14761350	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	59,94	aryl_hydrocarbon_receptor	14,39	2,3,7,8-tetrachlorodibenzo-p-dioxin	aryl hydrocarbon receptor	MESH:D013749	25690(Tax:10116)	Chemical	Gene	-RSB-|amod|START_ENTITY Induction|nmod|-RSB- Induction|nmod|mRNA mRNA|compound|END_ENTITY	-LSB- Induction of aryl_hydrocarbon_receptor and CYP1A1 mRNA by 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat liver -RSB- .
15004665	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	83,118	aryl_hydrocarbon_receptor	12,37	2,3,7,8-tetrachlorodibenzo-p-dioxin	aryl hydrocarbon receptor	MESH:D013749	11622(Tax:10090)	Chemical	Gene	activity|nmod|START_ENTITY Role|nmod|activity Role|nmod|END_ENTITY	Role of the aryl_hydrocarbon_receptor and Cyp1b1 in the antiestrogenic activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin .
15535986	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	22,57	aryl_hydrocarbon_receptor	135,160	2,3,7,8-tetrachlorodibenzo-p-dioxin	aryl hydrocarbon receptor	MESH:D013749	11622(Tax:10090)	Chemical	Gene	antagonism|nmod|START_ENTITY Lack|nmod|antagonism induction|nsubj|Lack induction|nmod|cytochrome_P4501A1 cytochrome_P4501A1|nmod|Hepa-1c1c7 Hepa-1c1c7|compound|END_ENTITY	Lack of antagonism of 2,3,7,8-tetrachlorodibenzo-p-dioxin 's -LRB- TCDDs -RRB- induction of cytochrome_P4501A1 -LRB- CYP1A1 -RRB- by the putative selective aryl_hydrocarbon_receptor modulator 6-alkyl-1 ,3,8 - trichlorodibenzofuran -LRB- 6-MCDF -RRB- in the mouse hepatoma cell line Hepa-1c1c7 .
16177221	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	79,114	aryl_hydrocarbon_receptor	45,70	2,3,7,8-tetrachlorodibenzo-p-dioxin	aryl hydrocarbon receptor	MESH:D013749	25690(Tax:10116)	Chemical	Gene	agonist|xcomp|START_ENTITY agonist|nsubj|Effects Effects|nmod|exposure exposure|nmod|END_ENTITY	Effects of acute and chronic exposure to the aryl_hydrocarbon_receptor agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin on the transition to reproductive senescence in female Sprague-Dawley_rats .
16556773	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	38,73	aryl_hydrocarbon_receptor	4,29	2,3,7,8-tetrachlorodibenzo-p-dioxin	aryl hydrocarbon receptor	MESH:D013749	11622(Tax:10090)	Chemical	Gene	alters|amod|START_ENTITY agonist|dobj|alters agonist|nsubj|END_ENTITY	The aryl_hydrocarbon_receptor agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin alters the circadian rhythms , quiescence , and expression of clock genes in murine hematopoietic stem and progenitor cells .
19269596	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	138,173	aryl_hydrocarbon_receptor	101,126	2,3,7,8-tetrachlorodibenzo-p-dioxin	aryl hydrocarbon receptor	MESH:D013749	196	Chemical	Gene	induced|advcl|START_ENTITY induced|nsubj|relationships relationships|nmod|anthraquinones anthraquinones|nmod|suppression suppression|nmod|activity activity|nmod|END_ENTITY	Structure-activity relationships of anthraquinones on the suppression of DNA-binding activity of the aryl_hydrocarbon_receptor induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin .
19490992	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	68,103	aryl_hydrocarbon_receptor	34,59	2,3,7,8-tetrachlorodibenzo-p-dioxin	aryl hydrocarbon receptor	MESH:D013749	25690(Tax:10116)	Chemical	Gene	agonist|xcomp|START_ENTITY agonist|nsubj|Effect Effect|nmod|exposure exposure|nmod|END_ENTITY	Effect of chronic exposure to the aryl_hydrocarbon_receptor agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin in female rats on ovarian gene expression .
20059580	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	79,114	aryl_hydrocarbon_receptor	45,70	2,3,7,8-tetrachlorodibenzo-p-dioxin	aryl hydrocarbon receptor	MESH:D013749	25690(Tax:10116)	Chemical	Gene	acyclicity|amod|START_ENTITY agonist|dobj|acyclicity agonist|nsubj|sensitivities sensitivities|nmod|END_ENTITY	Temporal and anatomical sensitivities to the aryl_hydrocarbon_receptor agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin leading to premature acyclicity with age in rats .
20486776	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	104,139	aryl_hydrocarbon_receptor	75,100	2,3,7,8-tetrachlorodibenzo-p-dioxin	aryl hydrocarbon receptor	MESH:D013749	11622(Tax:10090)	Chemical	Gene	disrupted|advcl|START_ENTITY disrupted|nmod|activation activation|nmod|END_ENTITY	Neural precursor cell proliferation is disrupted through activation of the aryl_hydrocarbon_receptor by 2,3,7,8-tetrachlorodibenzo-p-dioxin .
20876576	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	126,161	aryl_hydrocarbon_receptor	22,47	2,3,7,8-tetrachlorodibenzo-p-dioxin	aryl hydrocarbon receptor	MESH:D013749	196	Chemical	Gene	TiPARP|advcl|START_ENTITY TiPARP|nsubj|Identification Identification|nmod|gene gene|compound|END_ENTITY	Identification of the aryl_hydrocarbon_receptor target gene TiPARP as a mediator of suppression of hepatic gluconeogenesis by 2,3,7,8-tetrachlorodibenzo-p-dioxin and of nicotinamide as a corrective agent for this effect .
22634562	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	38,73	aryl_hydrocarbon_receptor	4,29	2,3,7,8-tetrachlorodibenzo-p-dioxin	aryl hydrocarbon receptor	MESH:D013749	196	Chemical	Gene	ligands|xcomp|START_ENTITY ligands|nsubj|END_ENTITY	The aryl_hydrocarbon_receptor ligands 2,3,7,8-tetrachlorodibenzo-p-dioxin and 3-methylcholanthrene regulate distinct genetic networks .
23800876	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	148,183	aryl_hydrocarbon_receptor	4,29	2,3,7,8-tetrachlorodibenzo-p-dioxin	aryl hydrocarbon receptor	MESH:D013749	11622(Tax:10090)	Chemical	Gene	quinoneoxidoreductase_1|nmod|START_ENTITY interacts|dobj|quinoneoxidoreductase_1 interacts|nsubj|END_ENTITY	The aryl_hydrocarbon_receptor interacts with nuclear_factor_erythroid_2-related_factor_2 to mediate induction of NAD -LRB- P -RRB- H : quinoneoxidoreductase_1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin .
24161567	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	71,106	aryl_hydrocarbon_receptor	130,155	2,3,7,8-tetrachlorodibenzo-p-dioxin	aryl hydrocarbon receptor	MESH:D013749	196	Chemical	Gene	model|nmod|START_ENTITY phenotype|nmod|model Induction|nmod|phenotype dependent|nsubj|Induction dependent|nmod|activation activation|compound|END_ENTITY	Induction of a chloracne phenotype in an epidermal equivalent model by 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- is dependent on aryl_hydrocarbon_receptor activation and is not reproduced by aryl_hydrocarbon_receptor knock down .
24718703	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	25,60	aryl_hydrocarbon_receptor	81,106	2,3,7,8-tetrachlorodibenzo-p-dioxin	aryl hydrocarbon receptor	MESH:D013749	11622(Tax:10090)	Chemical	Gene	promotion|nmod|START_ENTITY dependent|nsubj|promotion dependent|nmod|END_ENTITY	Liver_tumor promotion by 2,3,7,8-tetrachlorodibenzo-p-dioxin is dependent on the aryl_hydrocarbon_receptor and TNF/IL -1 receptors .
26605247	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	0,35	aryl_hydrocarbon_receptor	59,84	2,3,7,8-tetrachlorodibenzo-p-dioxin	aryl hydrocarbon receptor	MESH:D013749	196	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	2,3,7,8-tetrachlorodibenzo-p-dioxin decrease expression of aryl_hydrocarbon_receptor in peripheral lymphocyte of b-thalassemia major patients .
9224809	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	108,143	aryl_hydrocarbon_receptor	79,104	2,3,7,8-tetrachlorodibenzo-p-dioxin	aryl hydrocarbon receptor	MESH:D013749	11622(Tax:10090)	Chemical	Gene	thymus|advcl|START_ENTITY thymus|nmod|activation activation|nmod|END_ENTITY	Cytokine gene expression during ontogeny in murine thymus on activation of the aryl_hydrocarbon_receptor by 2,3,7,8-tetrachlorodibenzo-p-dioxin .
9558089	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	30,65	aryl_hydrocarbon_receptor	92,117	2,3,7,8-tetrachlorodibenzo-p-dioxin	aryl hydrocarbon receptor	MESH:D013749	11622(Tax:10090)	Chemical	Gene	induced|advcl|START_ENTITY alterations|acl|induced dependent|nsubj|alterations dependent|nmod|activation activation|compound|END_ENTITY	Thymic alterations induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin are strictly dependent on aryl_hydrocarbon_receptor activation in hemopoietic cells .
9579024	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	60,95	aryl_hydrocarbon_receptor	127,152	2,3,7,8-tetrachlorodibenzo-p-dioxin	aryl hydrocarbon receptor	MESH:D013749	25690(Tax:10116)	Chemical	Gene	exhibit|amod|START_ENTITY dose|nmod|exhibit exposed|nmod|dose Sprague-Dawley_rats|acl|exposed sustained|nsubj|Sprague-Dawley_rats sustained|dobj|depletion depletion|nmod|protein protein|compound|END_ENTITY	Female Sprague-Dawley_rats exposed to a single oral dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin exhibit sustained depletion of aryl_hydrocarbon_receptor protein in liver , spleen , thymus , and lung .
9703964	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	67,102	aryl_hydrocarbon_receptor	133,158	2,3,7,8-tetrachlorodibenzo-p-dioxin	aryl hydrocarbon receptor	MESH:D013749	25690(Tax:10116)	Chemical	Gene	caused|nmod|START_ENTITY expression|acl|caused differences|nmod|expression differences|dep|role role|nmod|END_ENTITY	Strain differences in cytochrome_P4501A1 gene expression caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat liver : role of the aryl_hydrocarbon_receptor and its nuclear translocator .
15013435	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	38,73	aryl_hydrocarbon_receptor_repressor	84,119	2,3,7,8-tetrachlorodibenzo-p-dioxin	aryl hydrocarbon receptor repressor	MESH:D013749	498999(Tax:10116)	Chemical	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Primary structure and inducibility by 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- of aryl_hydrocarbon_receptor_repressor in a TCDD-sensitive and a TCDD-resistant rat strain .
11891538	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	24,59	cytochrome_P450	68,83	2,3,7,8-tetrachlorodibenzo-p-dioxin	cytochrome P450	MESH:D013749	4051	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|activity activity|amod|END_ENTITY	The environmental toxin 2,3,7,8-tetrachlorodibenzo-p-dioxin induces cytochrome_P450 activity in high passage PC_3 and DU 145 human prostate_cancer cell lines .
11097868	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	10,45	cytochrome_P450_1A1	67,86	2,3,7,8-tetrachlorodibenzo-p-dioxin	cytochrome P450 1A1	MESH:D013749	24296(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the expression of cytochrome_P450_1A1 , the aryl_hydrocarbon_receptor , and the aryl_hydrocarbon_receptor nuclear translocator in rat brain and pituitary .
8430419	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	10,45	epidermal_growth_factor_receptor	60,92	2,3,7,8-tetrachlorodibenzo-p-dioxin	epidermal growth factor receptor	MESH:D013749	100301647(Tax:8022)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- on the epidermal_growth_factor_receptor in hepatic plasma membranes of rainbow_trout .
8470122	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	10,45	epidermal_growth_factor_receptor	60,92	2,3,7,8-tetrachlorodibenzo-p-dioxin	epidermal growth factor receptor	MESH:D013749	100301647(Tax:8022)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- on the epidermal_growth_factor_receptor in hepatic plasma membranes of rainbow_trout -LRB- Oncorhynchus_mykiss -RRB- .
7612002	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	74,109	glyceraldehyde-3-phosphate_dehydrogenase	30,70	2,3,7,8-tetrachlorodibenzo-p-dioxin	glyceraldehyde-3-phosphate dehydrogenase	MESH:D013749	2597	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of glyceraldehyde-3-phosphate_dehydrogenase by 2,3,7,8-tetrachlorodibenzo-p-dioxin .
2567227	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	23,58	lipoprotein_lipase	77,95	2,3,7,8-tetrachlorodibenzo-p-dioxin	lipoprotein lipase	MESH:D013749	100135570(Tax:10141)	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nsubj|effect	Differential effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on adipose tissue lipoprotein_lipase activity in the guinea_pig , rat , hamster , rabbit , and mink .
3288212	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	97,132	lipoprotein_lipase	28,46	2,3,7,8-tetrachlorodibenzo-p-dioxin	lipoprotein lipase	MESH:D013749	100135570(Tax:10141)	Chemical	Gene	administration|nmod|START_ENTITY result|nmod|administration END_ENTITY|nmod|result	Reduction of adipose tissue lipoprotein_lipase activity as a result of in vivo administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin to the guinea_pig .
6466340	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	6,41	lipoprotein_lipase	51,69	2,3,7,8-tetrachlorodibenzo-p-dioxin	lipoprotein lipase	MESH:D013749	100135570(Tax:10141)	Chemical	Gene	TCDD|dep|START_ENTITY reduces|nsubj|TCDD reduces|dobj|activity activity|amod|END_ENTITY	TCDD -LRB- 2,3,7,8-tetrachlorodibenzo-p-dioxin -RRB- reduces lipoprotein_lipase activity in the adipose tissue of the guinea_pig .
6184059	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	50,85	ornithine_decarboxylase	14,37	2,3,7,8-tetrachlorodibenzo-p-dioxin	ornithine decarboxylase	MESH:D013749	24609(Tax:10116)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activity activity|amod|END_ENTITY	Inhibition of ornithine_decarboxylase activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin .
24594276	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	0,35	p27	65,68	2,3,7,8-tetrachlorodibenzo-p-dioxin	p27	MESH:D013749	83571(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- induces expression of p27 -LRB- kip -RRB- and FoxO3a in female rat cerebral cortex and PC12 cells .
20299546	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	0,35	p53	52,55	2,3,7,8-tetrachlorodibenzo-p-dioxin	p53	MESH:D013749	7157	Chemical	Gene	counteracts|nsubj|START_ENTITY counteracts|dobj|response response|compound|END_ENTITY	2,3,7,8-tetrachlorodibenzo-p-dioxin counteracts the p53 response to a genotoxicant by upregulating expression of the metastasis marker agr2 in the hepatocarcinoma cell line HepG2 .
8168101	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	25,60	pS2	90,93	2,3,7,8-tetrachlorodibenzo-p-dioxin	pS2	MESH:D013749	7031	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|amod|END_ENTITY	Antiestrogenic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on 17_beta-estradiol-induced pS2 expression .
1510582	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	74,109	phosphoenolpyruvate_carboxykinase	18,51	2,3,7,8-tetrachlorodibenzo-p-dioxin	phosphoenolpyruvate carboxykinase	MESH:D013749	362282(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY expression|nmod|treatment expression|amod|END_ENTITY	Decreased hepatic phosphoenolpyruvate_carboxykinase gene expression after 2,3,7,8-tetrachlorodibenzo-p-dioxin treatment : implications for the acute toxicity of chlorinated_dibenzo-p-dioxins in the rat .
8475501	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	75,110	phosphoenolpyruvate_carboxykinase	21,54	2,3,7,8-tetrachlorodibenzo-p-dioxin	phosphoenolpyruvate carboxykinase	MESH:D013749	362282(Tax:10116)	Chemical	Gene	Reduction|nmod|START_ENTITY Reduction|nmod|activity activity|compound|END_ENTITY	Reduction of hepatic phosphoenolpyruvate_carboxykinase -LRB- PEPCK -RRB- activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- is due to decreased mRNA levels .
8607146	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	15,50	transforming_growth_factor-beta2	54,86	2,3,7,8-tetrachlorodibenzo-p-dioxin	transforming growth factor-beta2	MESH:D013749	7042	Chemical	Gene	START_ENTITY|nmod|promoter promoter|amod|END_ENTITY	The actions of 2,3,7,8-tetrachlorodibenzo-p-dioxin on transforming_growth_factor-beta2 promoter activity are localized to the TATA box binding region and controlled through a tyrosine kinase-dependent pathway .
8553372	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	62,97	tumor_necrosis_factor	14,35	2,3,7,8-tetrachlorodibenzo-p-dioxin	tumor necrosis factor	MESH:D013749	443540(Tax:9940)	Chemical	Gene	restore|dobj|START_ENTITY fails|xcomp|restore fails|nsubj|Inhibition Inhibition|nmod|activity activity|compound|END_ENTITY	Inhibition of tumor_necrosis_factor activity fails to restore 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- - induced suppression of the antibody response to sheep red blood cells .
9067482	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	15,50	tumor_necrosis_factor	61,82	2,3,7,8-tetrachlorodibenzo-p-dioxin	tumor necrosis factor	MESH:D013749	21926(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|production production|amod|END_ENTITY	The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- on tumor_necrosis_factor -LRB- TNF -RRB- production by peritoneal cells .
23142599	0	2,3,7,8-tetrachlorodibenzo-p-dioxin	45,80	vitellogenin	14,26	2,3,7,8-tetrachlorodibenzo-p-dioxin	vitellogenin	MESH:D013749	101882735	Chemical	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	Inhibition of vitellogenin gene induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin is mediated by aryl_hydrocarbon_receptor_2 -LRB- AHR2 -RRB- in zebrafish -LRB- Danio_rerio -RRB- .
15258113	0	2,3,7-trichlorodibenzo-p-dioxin	25,56	cytochrome_P450	75,90	2,3,7-trichlorodibenzo-p-dioxin	cytochrome P450	null	4051	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|nmod|END_ENTITY	Sequential metabolism of 2,3,7-trichlorodibenzo-p-dioxin -LRB- 2,3,7-triCDD -RRB- by cytochrome_P450 and UDP-glucuronosyltransferase in human liver microsomes .
14218	0	2,3-DPG	25,32	CO2	77,80	2,3-DPG	CO2	MESH:D019794	717	Chemical	Gene	START_ENTITY|dep|use use|nmod|END_ENTITY	Prolonged maintenance of 2,3-DPG in liquid blood storage : use of an internal CO2 trap to stabilize pH. A close relationship exists between the decrease in concentration of 2,3-diphosphoglycerate -LRB- 2,3-DPG -RRB- and a fall in the pH of stored blood .
10197970	0	2,3-Diarylcyclopentenones	0,25	cyclooxygenase-2	61,77	2,3-Diarylcyclopentenones	cyclooxygenase-2	null	29527(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	2,3-Diarylcyclopentenones as orally active , highly selective cyclooxygenase-2 inhibitors .
24374341	0	2,3-Dihydroxy-quinoxaline	0,25	ATPase	34,40	2,3-Dihydroxy-quinoxaline	ATPase	MESH:C034983	1769	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|activity activity|amod|END_ENTITY	2,3-Dihydroxy-quinoxaline induces ATPase activity of Herpes Simplex Virus thymidine kinase .
15016592	0	2,3-Dimercaptopropanol	0,22	delta-aminolevulinate_dehydratase	108,141	2,3-Dimercaptopropanol	delta-aminolevulinate dehydratase	MESH:D004112	210	Chemical	Gene	2,3-dimercaptopropane-1-sulfonic|amod|START_ENTITY acid|amod|2,3-dimercaptopropane-1-sulfonic dimercaptosuccinic_acid|nsubj|acid dimercaptosuccinic_acid|dobj|END_ENTITY	2,3-Dimercaptopropanol , 2,3-dimercaptopropane-1-sulfonic _ acid , and meso-2 ,3 - dimercaptosuccinic_acid inhibit delta-aminolevulinate_dehydratase from human erythrocytes in vitro .
16168622	0	2,3-Dimercaptopropanol	0,22	delta-aminolevulinate_dehydratase	135,168	2,3-Dimercaptopropanol	delta-aminolevulinate dehydratase	MESH:D004112	210	Chemical	Gene	acid|amod|START_ENTITY acid|dep|inhibition inhibition|nmod|END_ENTITY	2,3-Dimercaptopropanol , 2,3-dimercaptopropane-1-sulfonic _ acid and meso-2 ,3 - dimercaptosuccinic_acid increase lead-induced inhibition of delta-aminolevulinate_dehydratase in vitro and ex vivo .
2547672	0	2,3-butanedione	10,25	myeloperoxidase	35,50	2,3-butanedione	myeloperoxidase	MESH:D003931	4353	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of 2,3-butanedione on human myeloperoxidase .
8776741	0	2,3-dichloro-alpha-methylbenzylamine	62,98	phenylethanolamine_N-methyltransferase	12,50	2,3-dichloro-alpha-methylbenzylamine	phenylethanolamine N-methyltransferase	MESH:C002569	24661(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Effect of a phenylethanolamine_N-methyltransferase inhibitor , 2,3-dichloro-alpha-methylbenzylamine , on the alpha-2-adrenoceptor function in the hypothalamus in rats .
16219466	0	2,3-dihydroisothiazole	65,87	growth_hormone	94,108	2,3-dihydroisothiazole	growth hormone	MESH:C507110	2688	Chemical	Gene	secretagogues|amod|START_ENTITY secretagogues|compound|END_ENTITY	Structure activity studies of the serine-AIB dipeptide domain in 2,3-dihydroisothiazole based growth_hormone secretagogues .
6860355	0	2,3-dihydroxypyridine	50,71	catechol-O-methyltransferase	18,46	2,3-dihydroxypyridine	catechol-O-methyltransferase	MESH:C035877	100155530(Tax:9823)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	The inhibition of catechol-O-methyltransferase by 2,3-dihydroxypyridine .
9783327	0	2,3-dimercaptopropanol	48,70	delta-Aminolevulinate_dehydratase	0,33	2,3-dimercaptopropanol	delta-Aminolevulinate dehydratase	MESH:D004112	210	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	delta-Aminolevulinate_dehydratase inhibition by 2,3-dimercaptopropanol is mediated by chelation of zinc from a site involved in maintaining cysteinyl residues in a reduced state .
22746947	0	2,4,5-TMBA	0,10	cyclooxygenase-2	35,51	2,4,5-TMBA	cyclooxygenase-2	null	19225(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	2,4,5-TMBA , a natural inhibitor of cyclooxygenase-2 , suppresses adipogenesis and promotes lipolysis in 3T3-L1 adipocytes .
17397476	0	2,4,5-trimethoxybenzaldehyde	33,61	COX-2	16,21	2,4,5-trimethoxybenzaldehyde	COX-2	MESH:C034031	4513	Chemical	Gene	Production|amod|START_ENTITY Production|nmod|END_ENTITY	Production of a COX-2 inhibitor , 2,4,5-trimethoxybenzaldehyde , with submerged cultured Antrodia camphorata .
15896733	0	2,4,6-trihydroxyacetophenone	68,96	cholesterol_7alpha-hydroxylase	19,49	2,4,6-trihydroxyacetophenone	cholesterol 7alpha-hydroxylase	MESH:C515490|MESH:C107067	1581	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of human cholesterol_7alpha-hydroxylase in HepG2 cells by 2,4,6-trihydroxyacetophenone .
7877140	0	2,4-Diamino-5-substituted-quinazolines	0,38	dihydrofolate_reductase	64,87	2,4-Diamino-5-substituted-quinazolines	dihydrofolate reductase	null	1719	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	2,4-Diamino-5-substituted-quinazolines as inhibitors of a human dihydrofolate_reductase with a site-directed mutation at position 22 and of the dihydrofolate_reductases from Pneumocystis_carinii and Toxoplasma_gondii .
7514157	0	2,4-Diamino-6-hydroxypyrimidine	0,31	GTP_cyclohydrolase_I	49,69	2,4-Diamino-6-hydroxypyrimidine	GTP cyclohydrolase I	MESH:C017202	396146(Tax:9031)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	2,4-Diamino-6-hydroxypyrimidine , an inhibitor of GTP_cyclohydrolase_I , suppresses nitric_oxide production by chicken macrophages .
21190849	0	2,4-Diaminopyrimidine	0,21	c-Met	36,41	2,4-Diaminopyrimidine	c-Met	MESH:C017205	17295(Tax:10090)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	2,4-Diaminopyrimidine inhibitors of c-Met kinase bearing benzoxazepine anilines .
12798316	0	2,4-Dicarboxy-pyrroles	0,22	mGluR1	52,58	2,4-Dicarboxy-pyrroles	mGluR1	null	14799(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|antagonists antagonists|amod|END_ENTITY	2,4-Dicarboxy-pyrroles as selective non-competitive mGluR1 antagonists : further characterization of 3,5-dimethyl _ pyrrole-2 ,4 - dicarboxylic_acid_2-propyl_ester_4 - -LRB- 1,2,2-trimethyl-propyl -RRB- _ ester and structure-activity relationships .
1989629	0	2,4-Dihydroxybenzylamine	0,24	glutathione_reductase	50,71	2,4-Dihydroxybenzylamine	glutathione reductase	MESH:C067001	2936	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	2,4-Dihydroxybenzylamine : a specific inhibitor of glutathione_reductase .
6345782	0	2,4-diamino-5-benzylpyrimidines	146,177	dihydrofolate_reductase	181,204	2,4-diamino-5-benzylpyrimidines	dihydrofolate reductase	null	1719	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Theory and application of molecular potential energy fields in molecular shape analysis : a quantitative structure -- activity relationship study of 2,4-diamino-5-benzylpyrimidines as dihydrofolate_reductase inhibitors .
25982074	0	2,4-diamino-5-fluoropyrimidine	16,46	protein_kinase_C_theta	62,84	2,4-diamino-5-fluoropyrimidine	protein kinase C theta	null	5588	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Optimization of 2,4-diamino-5-fluoropyrimidine derivatives as protein_kinase_C_theta inhibitors with mitigated time-dependent drug-drug interactions and P-gp liability .
25982074	0	2,4-diamino-5-fluoropyrimidine	16,46	protein_kinase_C_theta	62,84	2,4-diamino-5-fluoropyrimidine	protein kinase C theta	null	5588	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Optimization of 2,4-diamino-5-fluoropyrimidine derivatives as protein_kinase_C_theta inhibitors with mitigated time-dependent drug-drug interactions and P-gp liability .
15292175	0	2,4-diamino-6-hydroxypyrimidine	59,90	GTP_cyclohydrolase_I	24,44	2,4-diamino-6-hydroxypyrimidine	GTP cyclohydrolase I	MESH:C017202	2643	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	The mechanism of potent GTP_cyclohydrolase_I inhibition by 2,4-diamino-6-hydroxypyrimidine : requirement of the GTP_cyclohydrolase_I_feedback_regulatory_protein .
21074994	0	2,4-diaminopyrimidine	56,77	ALK	113,116	2,4-diaminopyrimidine	ALK	MESH:C017205	11682(Tax:10090)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Novel 2,3,4,5-tetrahydro-benzo -LSB- d -RSB- azepine derivatives of 2,4-diaminopyrimidine , selective and orally bioavailable ALK inhibitors with antitumor efficacy in ALCL mouse models .
16442284	0	2,4-diaminopyrimidines	16,38	GHS-R	42,47	2,4-diaminopyrimidines	GHS-R	null	2693	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|amod|END_ENTITY	Optimization of 2,4-diaminopyrimidines as GHS-R antagonists : side chain exploration .
10653719	1	2,4-dichlorophenol	89,107	DCP	109,112	2,4-dichlorophenol	DCP	MESH:C004762	1636	Chemical	Gene	-RSB-|amod|START_ENTITY -RSB-|compound|END_ENTITY	strain DP-4 with a low substrate -LRB- 2,4-dichlorophenol -LSB- DCP -RSB- -RRB- concentration in a mineral medium from which uncharacterized organic compounds were eliminated by a non-DCP-degrading organism .
9403065	0	2,4-dienoyl-CoA	66,81	DECR	98,102	2,4-dienoyl-CoA	DECR	null	1666	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular cloning and characterization of the human mitochondrial 2,4-dienoyl-CoA _ reductase gene -LRB- DECR -RRB- .
7821682	0	2,4-difluorobenzyldimethylsilylmethanamine	46,88	monoamine_oxidase-B	126,145	2,4-difluorobenzyldimethylsilylmethanamine	monoamine oxidase-B	MESH:C091486	4129	Chemical	Gene	evaluation|nmod|START_ENTITY evaluation|nmod|END_ENTITY	Biochemical and pharmacological evaluation of 2,4-difluorobenzyldimethylsilylmethanamine , a new highly selective inhibitor of monoamine_oxidase-B .
22651858	0	2,4-dinitroaryldithiocarbamate	44,74	monoacylglycerol_lipase	96,119	2,4-dinitroaryldithiocarbamate	monoacylglycerol lipase	null	11343	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Synthesis and pharmacological evaluation of 2,4-dinitroaryldithiocarbamate derivatives as novel monoacylglycerol_lipase inhibitors .
6288084	0	2,4-dinitrophenol	24,41	ATPase	89,95	2,4-dinitrophenol	ATPase	MESH:D019297	1769	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Differential effects of 2,4-dinitrophenol and valinomycin -LRB- + K + -RRB- on uncoupler-stimulated ATPase of human tumor mitochondria .
21342117	0	2,4-dinitrophenyl-S-glutathione	99,130	ABC	64,67	2,4-dinitrophenyl-S-glutathione	ABC	null	10058	Chemical	Gene	efflux|nmod|START_ENTITY efflux|compound|END_ENTITY	Application of human placental villous tissue explants to study ABC transporter mediated efflux of 2,4-dinitrophenyl-S-glutathione .
15901347	0	2,4-dinitrophenyl-S-glutathione	38,69	multidrug_resistance-associated_protein_2	73,114	2,4-dinitrophenyl-S-glutathione	multidrug resistance-associated protein 2	null	25303(Tax:10116)	Chemical	Gene	START_ENTITY|appos|substrate substrate|amod|END_ENTITY	Modulation of intestinal transport of 2,4-dinitrophenyl-S-glutathione , a multidrug_resistance-associated_protein_2 substrate , by bilirubin treatment in rats .
18492610	0	2,4-thiazolidinedione	131,152	aldose_reductase	60,76	2,4-thiazolidinedione	aldose reductase	MESH:C089946	231	Chemical	Gene	derivatives|amod|START_ENTITY activity|nmod|derivatives activity|amod|END_ENTITY	Synthesis , induced-fit docking investigations , and in vitro aldose_reductase inhibitory activity of non-carboxylic_acid containing 2,4-thiazolidinedione derivatives .
22118090	0	2,4-thiazolidinedione	34,55	insulin	59,66	2,4-thiazolidinedione	insulin	MESH:C089946	280829(Tax:9913)	Chemical	Gene	START_ENTITY|nmod|responses responses|compound|END_ENTITY	Effects of plane of nutrition and 2,4-thiazolidinedione on insulin responses and adipose tissue gene expression in dairy cattle during late gestation .
16569497	0	2,5,6-tribromogramine	61,82	Neurotrophic_factor	0,19	2,5,6-tribromogramine	Neurotrophic factor	MESH:C522641	4908	Chemical	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Neurotrophic_factor production in human astrocytoma cells by 2,5,6-tribromogramine via activation of epsilon isoform of protein_kinase_C .
17892867	0	2,5-Deoxyfructosazine	0,21	interleukin-2	67,80	2,5-Deoxyfructosazine	interleukin-2	null	3558	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	2,5-Deoxyfructosazine , a D-glucosamine derivative , inhibits T-cell interleukin-2 production better than D-glucosamine .
14687764	0	2,5-Hexanedione	0,15	acetylcholinesterase	35,55	2,5-Hexanedione	acetylcholinesterase	MESH:C011269	83817(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	2,5-Hexanedione inhibits rat brain acetylcholinesterase activity in vitro .
3684951	0	2,5-diphenyloxazole	18,37	PPO	39,42	2,5-diphenyloxazole	PPO	MESH:C009012	5498	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|appos|END_ENTITY	The metabolism of 2,5-diphenyloxazole -LRB- PPO -RRB- in human lymphocytes and rat liver microsomes .
2402339	0	2,5-hexanedione	14,29	ornithine_decarboxylase	50,73	2,5-hexanedione	ornithine decarboxylase	MESH:C011269	24609(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|induction induction|nmod|END_ENTITY	The effect of 2,5-hexanedione on the induction of ornithine_decarboxylase in the dorsal root ganglion of the rat .
9714723	0	2,6-Dimethylheptanoyl-CoA	0,25	long-chain_acyl-CoA_dehydrogenase	54,87	2,6-Dimethylheptanoyl-CoA	long-chain acyl-CoA dehydrogenase	MESH:C114517	33	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	2,6-Dimethylheptanoyl-CoA is a specific substrate for long-chain_acyl-CoA_dehydrogenase -LRB- LCAD -RRB- : evidence for a major role of LCAD in branched-chain fatty_acid oxidation .
7703981	0	2,6-dimethylphenylphthalimide	82,111	tumor_necrosis_factor-alpha	51,78	2,6-dimethylphenylphthalimide	tumor necrosis factor-alpha	MESH:C092905	7124	Chemical	Gene	Enhancement|nmod|START_ENTITY Enhancement|nmod|END_ENTITY	Enhancement of phorbol_ester-induced production of tumor_necrosis_factor-alpha by 2,6-dimethylphenylphthalimide .
2354414	0	2,6-dinitrotoluene	78,96	CD-1	105,109	2,6-dinitrotoluene	CD-1	MESH:C023514	111334(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|compound|END_ENTITY	Comparative gastrointestinal enzyme activity and activation of the promutagen 2,6-dinitrotoluene in male CD-1 mice and male Fischer 344 rats .
24905202	0	2-5A	95,99	RNase_L	74,81	2-5A	RNase L	null	6041	Chemical	Gene	signaling|nmod|START_ENTITY signaling|nmod|END_ENTITY	Viral phosphodiesterases that antagonize double-stranded RNA signaling to RNase_L by degrading 2-5A .
17539917	0	2-AG	46,50	COX-2	0,5	2-AG	COX-2	CHEBI:52392	5743	Chemical	Gene	metabolite|nmod|START_ENTITY metabolite|compound|END_ENTITY	COX-2 oxidative metabolite of endocannabinoid 2-AG enhances excitatory glutamatergic synaptic transmission and induces neurotoxicity .
26974857	0	2-AG	13,17	monoacylglycerol_lipase	21,44	2-AG	monoacylglycerol lipase	CHEBI:52392	29254(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|amod|END_ENTITY	Elevation of 2-AG by monoacylglycerol_lipase inhibition in the visceral insular cortex interferes with anticipatory nausea in a rat model .
14670622	0	2-Acetylaminofluorene	0,21	interleukin-1beta	31,48	2-Acetylaminofluorene	interleukin-1beta	MESH:D015073	16176(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	2-Acetylaminofluorene inhibits interleukin-1beta production in LPS-stimulated macrophages by blocking NF-kappaB/Rel activation .
19731280	0	2-Acylaminopyridin-4-ylimidazoles	0,33	p38	37,40	2-Acylaminopyridin-4-ylimidazoles	p38	null	1432	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	2-Acylaminopyridin-4-ylimidazoles as p38 MAP kinase inhibitors : Design , synthesis , and biological and metabolic evaluations .
24534486	0	2-Amino-7-substituted_benzoxazole	0,33	RSK2	52,56	2-Amino-7-substituted benzoxazole	RSK2	null	6197	Chemical	Gene	analogs|amod|START_ENTITY analogs|nmod|END_ENTITY	2-Amino-7-substituted_benzoxazole analogs as potent RSK2 inhibitors .
26235167	0	2-Aminoacetamide	50,66	Peroxisome_Proliferator-Activated_Receptor	82,124	2-Aminoacetamide	Peroxisome Proliferator-Activated Receptor	CHEBI:42843	19013(Tax:10090)	Chemical	Gene	Derivatives|amod|START_ENTITY Derivatives|nmod|END_ENTITY	Synthesis and Structure-Activity Relationships of 2-Aminoacetamide Derivatives as Peroxisome_Proliferator-Activated_Receptor a/y Dual Agonists .
25981690	0	2-Aminoalkyl_nicotinamide	0,25	ghrelin_receptor	70,86	2-Aminoalkyl nicotinamide	ghrelin receptor	null	208188(Tax:10090)	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	2-Aminoalkyl_nicotinamide derivatives as pure inverse agonists of the ghrelin_receptor .
25981690	0	2-Aminoalkyl_nicotinamide	0,25	ghrelin_receptor	70,86	2-Aminoalkyl nicotinamide	ghrelin receptor	null	208188(Tax:10090)	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	2-Aminoalkyl_nicotinamide derivatives as pure inverse agonists of the ghrelin_receptor .
18553956	0	2-Aminobenzophenones	0,20	bradykinin_B1_receptor	41,63	2-Aminobenzophenones	bradykinin B1 receptor	null	81509(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|antagonists antagonists|amod|END_ENTITY	2-Aminobenzophenones as a novel class of bradykinin_B1_receptor antagonists .
18420409	0	2-Aminomethyl_piperidines	0,25	urotensin-II_receptor	35,56	2-Aminomethyl piperidines	urotensin-II receptor	null	2837	Chemical	Gene	START_ENTITY|nmod|antagonists antagonists|amod|END_ENTITY	2-Aminomethyl_piperidines as novel urotensin-II_receptor antagonists .
26985297	0	2-Aminooxazolines	34,51	TAAR1	99,104	2-Aminooxazolines	TAAR1	null	134864	Chemical	Gene	Agonists|amod|START_ENTITY Agonists|compound|END_ENTITY	Discovery and Characterization of 2-Aminooxazolines as Highly Potent , Selective , and Orally Active TAAR1 Agonists .
20137932	0	2-Aminothiadiazole	0,18	AKT1	33,37	2-Aminothiadiazole	AKT1	null	11651(Tax:10090)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	2-Aminothiadiazole inhibitors of AKT1 as potential cancer therapeutics .
8779635	0	2-Anthracenonyl_acetic_acids	0,28	5-lipoxygenase	32,46	2-Anthracenonyl acetic acids	5-lipoxygenase	null	240	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	2-Anthracenonyl_acetic_acids as 5-lipoxygenase inhibitors .
15774549	0	2-Arachidonoyl-glycerol	0,23	interferon-gamma	35,51	2-Arachidonoyl-glycerol	interferon-gamma	MESH:C094503	15978(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY production|amod|END_ENTITY	2-Arachidonoyl-glycerol suppresses interferon-gamma production in phorbol_ester / ionomycin-activated mouse splenocytes independent of CB1 or CB2 .
23689009	0	2-Arachidonoylglycerol	0,22	butyrylcholinesterase	42,63	2-Arachidonoylglycerol	butyrylcholinesterase	MESH:C094503	590	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	2-Arachidonoylglycerol is a substrate for butyrylcholinesterase : A potential mechanism for extracellular endocannabinoid regulation .
11011050	0	2-Arachidonylglycerol	0,21	tumor_necrosis_factor-alpha	59,86	2-Arachidonylglycerol	tumor necrosis factor-alpha	MESH:C094503	21926(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	2-Arachidonylglycerol , an endogenous cannabinoid , inhibits tumor_necrosis_factor-alpha production in murine macrophages , and in mice .
27096045	0	2-Aryl_Benzimidazole	73,93	BCATm	94,99	2-Aryl Benzimidazole	BCATm	null	12036(Tax:10090)	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|compound|END_ENTITY	Discovery and Optimization of Potent , Selective , and in Vivo Efficacious 2-Aryl_Benzimidazole BCATm Inhibitors .
11354384	0	2-Aryl_indole	0,13	NK1_receptor	14,26	2-Aryl indole	NK1 receptor	null	6869	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|amod|END_ENTITY	2-Aryl_indole NK1_receptor antagonists : optimisation of indole substitution .
11354385	0	2-Aryl_indole	0,13	NK1_receptor	14,26	2-Aryl indole	NK1 receptor	null	6869	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|amod|END_ENTITY	2-Aryl_indole NK1_receptor antagonists : optimisation of the 2-aryl ring and the indole nitrogen substituent .
17289385	1	2-Aryl_indoles	36,50	ERalpha	91,98	2-Aryl indoles	ERalpha	null	2099	Chemical	Gene	ligands|amod|START_ENTITY ligands|nmod|END_ENTITY	Part_16 : 2-Aryl_indoles as highly subtype selective ligands for ERalpha .
11859012	0	2-Arylindoles	0,13	gonadotropin_releasing_hormone	17,47	2-Arylindoles	gonadotropin releasing hormone	null	2796	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|amod|END_ENTITY	2-Arylindoles as gonadotropin_releasing_hormone -LRB- GnRH -RRB- antagonists : optimization of the tryptamine side chain .
19299126	0	2-Azidoalkoxy-7-hydro-8-oxoadenine	0,34	TLR7	50,54	2-Azidoalkoxy-7-hydro-8-oxoadenine	TLR7	null	51284	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	2-Azidoalkoxy-7-hydro-8-oxoadenine derivatives as TLR7 agonists inducing dendritic cell maturation .
10928332	0	2-Bromoethylamine	0,17	semicarbazide-sensitive_amine_oxidase	55,92	2-Bromoethylamine	semicarbazide-sensitive amine oxidase	MESH:C004504	314	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	2-Bromoethylamine , a suicide inhibitor of tissue-bound semicarbazide-sensitive_amine_oxidase .
11266660	0	2-Bromoethylamine	0,17	semicarbazide-sensitive_amine_oxidase	62,99	2-Bromoethylamine	semicarbazide-sensitive amine oxidase	MESH:C004504	314	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	2-Bromoethylamine as a potent selective suicide inhibitor for semicarbazide-sensitive_amine_oxidase .
24589594	0	2-Deoxy-D-glucose	1,18	VEGF	48,52	2-Deoxy-D-glucose	VEGF	MESH:D003847	22339(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	-LSB- 2-Deoxy-D-glucose combined with Taxol inhibits VEGF expression and induces apoptosis in orthotopically transplanted breast_cancer in C3H mice -RSB- .
26939025	0	2-Deoxyglucose	0,14	Insulin	48,55	2-Deoxyglucose	Insulin	MESH:D003847	3630	Chemical	Gene	Reverses|nsubj|START_ENTITY Reverses|xcomp|Effect Effect|nmod|END_ENTITY	2-Deoxyglucose Reverses the Promoting Effect of Insulin on Colorectal_Cancer Cells In Vitro .
1673444	0	2-Deoxyglucose	0,14	insulin	41,48	2-Deoxyglucose	insulin	MESH:D003847	3630	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|nmod|END_ENTITY	2-Deoxyglucose stimulates the release of insulin and somatostatin from the perfused catfish pancreas .
26315267	0	2-Deoxyglucose	0,14	thioredoxin_interacting_protein	41,72	2-Deoxyglucose	thioredoxin interacting protein	MESH:D003847	10628	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	2-Deoxyglucose induces the expression of thioredoxin_interacting_protein -LRB- TXNIP -RRB- by increasing O-GlcNAcylation - Implications for targeting the Warburg effect in cancer cells .
15655521	0	2-Furoyl-LIGRL-NH2	0,18	proteinase-activated_receptor-2	41,72	2-Furoyl-LIGRL-NH2	proteinase-activated receptor-2	null	14063(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonist agonist|nmod|END_ENTITY	2-Furoyl-LIGRL-NH2 , a potent agonist for proteinase-activated_receptor-2 , as a gastric mucosal cytoprotective agent in mice .
8891164	0	2-Glycineamide-5-chlorophenyl_2-pyrryl_ketone	0,45	Tat	67,70	2-Glycineamide-5-chlorophenyl 2-pyrryl ketone	Tat	MESH:C103626	155871(Tax:11676)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	2-Glycineamide-5-chlorophenyl_2-pyrryl_ketone , a non-benzodiazepin Tat antagonist , is effective against acute_and_chronic_HIV-1_infections in vitro .
10083839	0	2-Hydroxy-4-methoxybenzaldehyde	0,31	tyrosinase	42,52	2-Hydroxy-4-methoxybenzaldehyde	tyrosinase	MESH:C118297	7299	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	2-Hydroxy-4-methoxybenzaldehyde : a potent tyrosinase inhibitor from African medicinal plants .
8576908	0	2-Iminopiperidine	0,17	nitric_oxide_synthase	81,102	2-Iminopiperidine	nitric oxide synthase	null	4843	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	2-Iminopiperidine and other 2-iminoazaheterocycles as potent inhibitors of human nitric_oxide_synthase isoforms .
2362451	0	2-Iodoestradiol	0,15	sex_hormone_binding_globulin	50,78	2-Iodoestradiol	sex hormone binding globulin	MESH:C053381	6462	Chemical	Gene	binds|amod|START_ENTITY binds|nmod|END_ENTITY	2-Iodoestradiol binds with high affinity to human sex_hormone_binding_globulin -LRB- SHBG -RRB- .
17157814	0	2-Keto-4-methylthiobutyrate	0,27	CtBP1	104,109	2-Keto-4-methylthiobutyrate	CtBP1	MESH:C014632	1487	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	2-Keto-4-methylthiobutyrate , an intermediate in the methionine salvage pathway , is a good substrate for CtBP1 .
3162218	0	2-Mercaptoethylamine	0,20	spermidine_synthase	49,68	2-Mercaptoethylamine	spermidine synthase	null	6723	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	2-Mercaptoethylamine , a competitive inhibitor of spermidine_synthase in mammalian cells .
7553614	0	2-Methoxy-4-nitroaniline	0,24	cytochrome_P450IA2	51,69	2-Methoxy-4-nitroaniline	cytochrome P450IA2	null	24297(Tax:10116)	Chemical	Gene	inducer|nsubj|START_ENTITY inducer|nmod|END_ENTITY	2-Methoxy-4-nitroaniline is a selective inducer of cytochrome_P450IA2 -LRB- CYP1A2 -RRB- in rat liver .
26802903	0	2-Methoxy-6-acetyl-7-methyljuglone	0,34	JNK	133,136	2-Methoxy-6-acetyl-7-methyljuglone	JNK	null	5599	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	2-Methoxy-6-acetyl-7-methyljuglone -LRB- MAM -RRB- , a natural naphthoquinone , induces NO-dependent apoptosis and necroptosis by H2O2-dependent JNK activation in cancer cells .
22033407	0	2-Methoxycinnamaldehyde	0,23	Tie2	67,71	2-Methoxycinnamaldehyde	Tie2	MESH:C017910	7010	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|suppressing suppressing|dobj|activation activation|amod|END_ENTITY	2-Methoxycinnamaldehyde inhibits tumor angiogenesis by suppressing Tie2 activation .
1733052	0	2-Methoxyethanol	0,16	CD-1	40,44	2-Methoxyethanol	CD-1	MESH:C005219	111334(Tax:10090)	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|nmod|mice mice|compound|END_ENTITY	2-Methoxyethanol metabolism in pregnant CD-1 mice and embryos .
24450414	0	2-Methoxystypandrone	0,20	signal_transducer_and_activator_of_transcription_3_and_nuclear_factor-kB	30,102	2-Methoxystypandrone	signal transducer and activator of transcription 3 and nuclear factor-kB	MESH:C447630	6774	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	2-Methoxystypandrone inhibits signal_transducer_and_activator_of_transcription_3_and_nuclear_factor-kB signaling by inhibiting Janus_kinase_2 and IkB kinase .
19815944	0	2-Methyl-6-phenylethynyl-pyridine	0,33	mGluR5	60,66	2-Methyl-6-phenylethynyl-pyridine	mGluR5	MESH:C121465	14805(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	2-Methyl-6-phenylethynyl-pyridine -LRB- MPEP -RRB- , a non-competitive mGluR5 antagonist , differentially affects the anticonvulsant activity of four conventional antiepileptic drugs against amygdala-kindled seizures in rats .
7549921	0	2-Methyl-L-tryptophan	0,21	tryptophanase	40,53	2-Methyl-L-tryptophan	tryptophanase	null	6999	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	2-Methyl-L-tryptophan is a substrate of tryptophanase .
11233991	0	2-Naphthylamine	0,15	monoamine_oxidase_A	69,88	2-Naphthylamine	monoamine oxidase A	MESH:D015081	17161(Tax:10090)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|END_ENTITY	2-Naphthylamine , a compound found in cigarette smoke , decreases both monoamine_oxidase_A and B catalytic activity .
17603200	0	2-Nonylaminopyridine	28,48	PPAR	64,68	2-Nonylaminopyridine	PPAR	null	5465	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Synthesis and evaluation of 2-Nonylaminopyridine derivatives as PPAR ligands .
24325600	0	2-O	0,3	HMGB-1	65,71	2-O	HMGB-1	null	15289(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|compound|END_ENTITY	2-O , 3-O-desulfated_heparin inhibits neutrophil elastase-induced HMGB-1 secretion and airway_inflammation .
27059979	0	2-O-Arachidonylglycerol_Ether	16,45	Cyclooxygenase-2	112,128	2-O-Arachidonylglycerol Ether	Cyclooxygenase-2	null	5743	Chemical	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of 2-O-Arachidonylglycerol_Ether and Ibuprofen with The Allosteric and Catalytic Subunits of Human Cyclooxygenase-2 .
17728130	0	2-O-carboxymethylpyrogallol	0,27	PTP1B	43,48	2-O-carboxymethylpyrogallol	PTP1B	null	19246(Tax:10090)	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	2-O-carboxymethylpyrogallol derivatives as PTP1B inhibitors with antihyperglycemic activity .
2840070	0	2-O-tetradecanoylphorbol-13-acetate	43,78	c-mos	11,16	2-O-tetradecanoylphorbol-13-acetate	c-mos	null	17451(Tax:10090)	Chemical	Gene	Changes|nmod|START_ENTITY Changes|nmod|expression expression|amod|END_ENTITY	Changes of c-mos expression in response to 2-O-tetradecanoylphorbol-13-acetate in undifferentiated teratocarcinoma cells .
19775891	0	2-Oxoglutarate	0,14	prolyl_hydroxylase_domain_2	38,65	2-Oxoglutarate	prolyl hydroxylase domain 2	MESH:C029743	54583	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	2-Oxoglutarate analogue inhibitors of prolyl_hydroxylase_domain_2 .
16883594	0	2-Oxoglutarate	0,14	vascular_endothelial_growth_factor	43,77	2-Oxoglutarate	vascular endothelial growth factor	MESH:C029743	7422	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|nmod|END_ENTITY	2-Oxoglutarate downregulates expression of vascular_endothelial_growth_factor and erythropoietin through decreasing hypoxia-inducible_factor-1alpha and inhibits angiogenesis .
12629525	0	2-PMPA	164,170	glutamate_carboxypeptidase_II	103,132	2-PMPA	glutamate carboxypeptidase II	null	53320(Tax:10090)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	Morphine tolerance and reward but not expression of morphine dependence are inhibited by the selective glutamate_carboxypeptidase_II -LRB- GCP_II , NAALADase -RRB- inhibitor , 2-PMPA .
9884311	0	2-S-glutathionyl_acetate	46,70	CYP2E1	11,17	2-S-glutathionyl acetate	CYP2E1	MESH:C117291	13106(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Diminished CYP2E1 expression and formation of 2-S-glutathionyl_acetate , a glutathione conjugate derived from 1,1-dichloroethylene _ epoxide , in murine lung_tumors .
26945337	0	2-Succinocysteine	25,42	Aid	105,108	2-Succinocysteine	Aid	null	57379	Chemical	Gene	Immunohistochemistry|nmod|START_ENTITY Immunohistochemistry|nmod|END_ENTITY	Immunohistochemistry for 2-Succinocysteine -LRB- 2SC -RRB- and Fumarate_Hydratase -LRB- FH -RRB- in Cutaneous_Leiomyomas May Aid in Identification of Patients With HLRCC -LRB- Hereditary_Leiomyomatosis and Renal_Cell_Carcinoma_Syndrome -RRB- .
21081474	0	2-Tellurium-bridged_b-cyclodextrin	0,34	thioredoxin_reductase	38,59	2-Tellurium-bridged b-cyclodextrin	thioredoxin reductase	null	25824	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	2-Tellurium-bridged_b-cyclodextrin , a thioredoxin_reductase inhibitor , sensitizes human breast_cancer cells to TRAIL-induced apoptosis through DR5 induction and NF-kB suppression .
25559428	0	2-Thiazolidinones	33,50	BRD4	54,58	2-Thiazolidinones	BRD4	null	23476	Chemical	Gene	START_ENTITY|nmod|Inhibitors Inhibitors|compound|END_ENTITY	Fragment-Based Drug Discovery of 2-Thiazolidinones as BRD4 Inhibitors : 2 .
9822550	0	2-acetoxyphenyl_alkyl_sulfides	53,83	cyclooxygenase-2	25,41	2-acetoxyphenyl alkyl sulfides	cyclooxygenase-2	null	19225(Tax:10090)	Chemical	Gene	modification|nmod|START_ENTITY modification|nmod|END_ENTITY	Covalent modification of cyclooxygenase-2 -LRB- COX-2 -RRB- by 2-acetoxyphenyl_alkyl_sulfides , a new class of selective COX-2 inactivators .
11960367	0	2-acetylaminofluorene	43,64	MDR1	19,23	2-acetylaminofluorene	MDR1	MESH:D015073	5243	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Induction of human MDR1 gene expression by 2-acetylaminofluorene is mediated by effectors of the phosphoinositide 3-kinase pathway that activate NF-kappaB signaling .
2880590	0	2-acetylaminofluorene	67,88	cytochrome_P-450	27,43	2-acetylaminofluorene	cytochrome P-450	MESH:D015073	25251(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|metabolism metabolism|amod|END_ENTITY	Effect of dexamethasone on cytochrome_P-450 mediated metabolism of 2-acetylaminofluorene in cultured rat hepatocytes .
3488741	0	2-acetylaminofluorene	116,137	cytochrome_P-450	13,29	2-acetylaminofluorene	cytochrome P-450	MESH:D015073	25251(Tax:10116)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|activities activities|amod|END_ENTITY	Induction of cytochrome_P-450 and related drug-metabolizing activities in the livers of different rodent species by 2-acetylaminofluorene or by 3-methylcholanthrene .
4122821	0	2-acetylaminofluorene	51,72	cytochrome_P-450	12,28	2-acetylaminofluorene	cytochrome P-450	MESH:D015073	4051	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of cytochrome_P-450 in N-hydroxylation of 2-acetylaminofluorene .
3943517	0	2-acetylaminofluorene	104,125	microsomal_epoxide_hydrolase	59,87	2-acetylaminofluorene	microsomal epoxide hydrolase	MESH:D015073	25315(Tax:10116)	Chemical	Gene	compounds|amod|START_ENTITY END_ENTITY|nmod|compounds	Induction of different isozymes of cytochrome_P-450 and of microsomal_epoxide_hydrolase in rat liver by 2-acetylaminofluorene and structurally related compounds .
2009275	0	2-acetylaminofluorene	129,150	transferrin	61,72	2-acetylaminofluorene	transferrin	MESH:D015073	7018	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	NADH oxidase of liver plasma membrane stimulated by diferric transferrin and neoplastic transformation induced by the carcinogen 2-acetylaminofluorene .
23419736	0	2-alkylthio_substituted_naphthoquinones	31,70	ACAT	120,124	2-alkylthio substituted naphthoquinones	ACAT	null	6646	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Synthesis of a novel series of 2-alkylthio_substituted_naphthoquinones as potent acyl-CoA : _ cholesterol_acyltransferase -LRB- ACAT -RRB- inhibitors .
17488003	0	2-amino-6-halopurine	34,54	heat_shock_protein_90	55,76	2-amino-6-halopurine	heat shock protein 90	null	3320	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Rationally designed high-affinity 2-amino-6-halopurine heat_shock_protein_90 inhibitors that exhibit potent antitumor activity .
2158439	0	2-amino-7-phosphonoheptanoic_acid	10,43	APH	45,48	2-amino-7-phosphonoheptanoic acid	APH	null	24206(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of 2-amino-7-phosphonoheptanoic_acid -LRB- APH -RRB- on seizure susceptibility in the prepubescent and mature rat .
22507882	0	2-amino-isoflavones	6,25	aryl_hydrocarbon_receptor	34,59	2-amino-isoflavones	aryl hydrocarbon receptor	null	196	Chemical	Gene	agonist|amod|START_ENTITY agonist|compound|END_ENTITY	Novel 2-amino-isoflavones exhibit aryl_hydrocarbon_receptor agonist or antagonist activity in a species/cell-specific context .
18790636	0	2-amino-isoxazolopyridines	24,50	Polo-like_kinase	54,70	2-amino-isoxazolopyridines	Polo-like kinase	null	5347	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Design and synthesis of 2-amino-isoxazolopyridines as Polo-like_kinase inhibitors .
21374822	0	2-aminoanilides	33,48	histone_deacetylase	52,71	2-aminoanilides	histone deacetylase	null	9734	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Novel cinnamyl_hydroxyamides and 2-aminoanilides as histone_deacetylase inhibitors : apoptotic induction and cytodifferentiation activity .
1378177	0	2-aminoanthracene	46,63	Cytochrome_P450	0,15	2-aminoanthracene	Cytochrome P450	MESH:C006593	25251(Tax:10116)	Chemical	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Cytochrome_P450 induction and mutagenicity of 2-aminoanthracene -LRB- 2AA -RRB- in rat liver and gut .
22704890	0	2-aminobenzamide	40,56	HSP90	78,83	2-aminobenzamide	HSP90	MESH:C000219	3320	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Anti-herpes simplex virus efficacies of 2-aminobenzamide derivatives as novel HSP90 inhibitors .
23719283	0	2-aminobenzimidazoles	71,92	acetylcholinesterase	116,136	2-aminobenzimidazoles	acetylcholinesterase	null	83817(Tax:10116)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Synthesis , biological evaluation and molecular modeling of substituted 2-aminobenzimidazoles as novel inhibitors of acetylcholinesterase and butyrylcholinesterase .
15806115	0	2-aminoethoxydiphenyl_borate	27,55	TRPC5	9,14	2-aminoethoxydiphenyl borate	TRPC5	MESH:C109986	7224	Chemical	Gene	channels|nmod|START_ENTITY channels|nummod|END_ENTITY	Block of TRPC5 channels by 2-aminoethoxydiphenyl_borate : a differential , extracellular and voltage-dependent effect .
15175387	0	2-aminoethoxydiphenyl_borate	0,28	TRPV3	81,86	2-aminoethoxydiphenyl borate	TRPV3	MESH:C109986	162514	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	2-aminoethoxydiphenyl_borate activates and sensitizes the heat-gated ion channel TRPV3 .
12680237	0	2-aminofluorene	49,64	N-acetyltransferase	78,97	2-aminofluorene	N-acetyltransferase	MESH:C012177	6046	Chemical	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Luteolin induces N-acetylation and DNA adduct of 2-aminofluorene accompanying N-acetyltransferase activity and gene expression in human bladder_cancer T24 cell line .
22209418	0	2-aminoimidazole	28,44	BACE-1	60,66	2-aminoimidazole	BACE-1	MESH:C014973	23621	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|inhibitors inhibitors|compound|END_ENTITY	A small chemical library of 2-aminoimidazole derivatives as BACE-1 inhibitors : Structure-based design , synthesis , and biological evaluation .
24120540	0	2-aminooxazole_amides	18,39	DGAT1	87,92	2-aminooxazole amides	DGAT1	null	13350(Tax:10090)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Identification of 2-aminooxazole_amides as acyl-CoA : diacylglycerol acyltransferase 1 -LRB- DGAT1 -RRB- inhibitors through scaffold hopping strategy .
22863529	0	2-aminopyridine-3-carboxamides	19,49	c-Met	53,58	2-aminopyridine-3-carboxamides	c-Met	null	4233	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Discovery of novel 2-aminopyridine-3-carboxamides as c-Met kinase inhibitors .
16884310	0	2-aminopyrimidine_carbamates	6,34	Lck	77,80	2-aminopyrimidine carbamates	Lck	null	16818(Tax:10090)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Novel 2-aminopyrimidine_carbamates as potent and orally active inhibitors of Lck : synthesis , SAR , and in vivo antiinflammatory activity .
22437109	0	2-anilino-4-aryl-8H-purine	0,26	PDK1	56,60	2-anilino-4-aryl-8H-purine	PDK1	null	228026(Tax:10090)	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	2-anilino-4-aryl-8H-purine derivatives as inhibitors of PDK1 .
19616958	0	2-anilinobenzamide	74,92	SIRT1	108,113	2-anilinobenzamide	SIRT1	null	23411	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Design , synthesis , enzyme inhibition , and tumor cell growth inhibition of 2-anilinobenzamide derivatives as SIRT1 inhibitors .
17919905	0	2-anilinothiazolones	17,37	11beta-HSD1	41,52	2-anilinothiazolones	11beta-HSD1	null	25116;24470	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	The discovery of 2-anilinothiazolones as 11beta-HSD1 inhibitors .
18297109	0	2-arachidonoylglycerol	67,89	COX-2	47,52	2-arachidonoylglycerol	COX-2	MESH:C094503	29527(Tax:10116)	Chemical	Gene	metabolite|nmod|START_ENTITY metabolite|compound|END_ENTITY	Prostaglandin_E2_glycerol_ester , an endogenous COX-2 metabolite of 2-arachidonoylglycerol , induces hyperalgesia and modulates NFkappaB activity .
18534982	0	2-arachidonoylglycerol	16,38	COX-2	68,73	2-arachidonoylglycerol	COX-2	MESH:C094503	5743	Chemical	Gene	protects|nsubj|START_ENTITY protects|advcl|limiting limiting|dobj|elevation elevation|compound|END_ENTITY	Endocannabinoid 2-arachidonoylglycerol protects neurons by limiting COX-2 elevation .
21501147	0	2-arachidonoylglycerol	50,72	COX-2	14,19	2-arachidonoylglycerol	COX-2	MESH:C094503	17709(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Inhibition of COX-2 expression by endocannabinoid 2-arachidonoylglycerol is mediated via PPAR-y .
18375719	0	2-arachidonoylglycerol	32,54	Cytochrome_P-450	0,16	2-arachidonoylglycerol	Cytochrome P-450	MESH:C094503	25251(Tax:10116)	Chemical	Gene	metabolites|nmod|START_ENTITY metabolites|amod|END_ENTITY	Cytochrome_P-450 metabolites of 2-arachidonoylglycerol play a role in Ca2 + - induced relaxation of rat mesenteric arteries .
20159446	0	2-arachidonoylglycerol	20,42	diacylglycerol_lipase_alpha	55,82	2-arachidonoylglycerol	diacylglycerol lipase alpha	MESH:C094503	269060(Tax:10090)	Chemical	Gene	START_ENTITY|acl|produced produced|nmod|END_ENTITY	The endocannabinoid 2-arachidonoylglycerol produced by diacylglycerol_lipase_alpha mediates retrograde suppression of synaptic transmission .
25068972	0	2-arachidonoylglycerol	10,32	myosin_light_chain	36,54	2-arachidonoylglycerol	myosin light chain	MESH:C094503	23209	Chemical	Gene	START_ENTITY|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Effect of 2-arachidonoylglycerol on myosin_light_chain phosphorylation and platelet activation : The role of phosphatidylinositol_3_kinase / AKT pathway .
18571623	0	2-arachidonyl_glycerol	50,72	IL-2	98,102	2-arachidonyl glycerol	IL-2	MESH:C094503	3558	Chemical	Gene	suppression|amod|START_ENTITY suppression|nmod|END_ENTITY	A COX-2 metabolite of the endogenous cannabinoid , 2-arachidonyl_glycerol , mediates suppression of IL-2 secretion in activated Jurkat T cells .
20356736	0	2-aryl-4-oxazolylmethoxy_benzylglycines	50,89	PPARalpha	152,161	2-aryl-4-oxazolylmethoxy benzylglycines	PPARalpha	null	5465	Chemical	Gene	activators|amod|START_ENTITY activators|amod|END_ENTITY	Synthesis and structure-activity relationships of 2-aryl-4-oxazolylmethoxy_benzylglycines and 2-aryl-4-thiazolylmethoxy_benzylglycines as novel , potent PPARalpha selective activators - PPARalpha and PPARgamma selectivity modulation .
15050645	0	2-aryl_oxazolo-pyrimidines	30,56	adenosine_kinase	60,76	2-aryl oxazolo-pyrimidines	adenosine kinase	null	132	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Discovery and optimization of 2-aryl_oxazolo-pyrimidines as adenosine_kinase inhibitors using liquid phase parallel synthesis .
22863203	0	2-arylmethyloxy-5-substitutent-N-arylbenzamide	43,89	LRRK2	90,95	2-arylmethyloxy-5-substitutent-N-arylbenzamide	LRRK2	null	66725(Tax:10090)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	GSK2578215A ; a potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor .
19140144	0	2-aryloxazole	40,53	BCRP	95,99	2-aryloxazole	BCRP	null	644079	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Multi-drug-resistance-reverting agents : 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors .
15225720	0	2-arylsulfanyl-phenyl_piperazinyl_acetic_acids	25,71	glyT-1	75,81	2-arylsulfanyl-phenyl piperazinyl acetic acids	glyT-1	null	116509(Tax:10116)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	The synthesis and SAR of 2-arylsulfanyl-phenyl_piperazinyl_acetic_acids as glyT-1 inhibitors .
16725323	0	2-arylsulfanylphenyl-1-oxyalkylamino_acids	25,67	GlyT-1	71,77	2-arylsulfanylphenyl-1-oxyalkylamino acids	GlyT-1	null	6536	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	The synthesis and SAR of 2-arylsulfanylphenyl-1-oxyalkylamino_acids as GlyT-1 inhibitors .
3186776	0	2-benzylaminophenols	42,62	5-lipoxygenase	24,38	2-benzylaminophenols	5-lipoxygenase	null	240	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of mammalian 5-lipoxygenase by 2-benzylaminophenols .
11361012	0	2-bromoethylamine	84,101	semicarbazide-sensitive_amine_oxidase	27,64	2-bromoethylamine	semicarbazide-sensitive amine oxidase	MESH:C004504	314	Chemical	Gene	haloamines|amod|START_ENTITY Inhibition|nmod|haloamines Inhibition|nmod|END_ENTITY	Inhibition of tissue-bound semicarbazide-sensitive_amine_oxidase by two haloamines , 2-bromoethylamine and 3-bromopropylamine .
3997834	0	2-bromooctanoate	48,64	diacylglycerol_acyltransferase	14,44	2-bromooctanoate	diacylglycerol acyltransferase	MESH:C019279	84497(Tax:10116)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of diacylglycerol_acyltransferase by 2-bromooctanoate in cultured rat hepatocytes .
5766656	0	2-bromostearate	81,96	insulin	21,28	2-bromostearate	insulin	MESH:C000320	3630	Chemical	Gene	alloxan-diabetes|nmod|START_ENTITY reversal|nmod|alloxan-diabetes reversal|nmod|resistance resistance|compound|END_ENTITY	Apparent reversal of insulin resistance in cardiac_muscle in alloxan-diabetes by 2-bromostearate .
6143716	0	2-bromostearate	102,117	insulin	40,47	2-bromostearate	insulin	MESH:C000320	3630	Chemical	Gene	changes|nmod|START_ENTITY changes|nmod|END_ENTITY	Starvation-induced secretory changes of insulin , somatostatin , and glucagon and their modification by 2-bromostearate .
11786238	0	2-buten-4-olide	0,15	acidic_fibroblast_growth_factor	95,126	2-buten-4-olide	acidic fibroblast growth factor	MESH:C004511	14164(Tax:10090)	Chemical	Gene	improves|nsubj|START_ENTITY improves|nmod|END_ENTITY	2-buten-4-olide , an endogenous feeding suppressant , improves spatial performance through brain acidic_fibroblast_growth_factor in mice .
15982877	0	2-carboxylic_acid_indoles	21,46	plasminogen_activator_inhibitor-1	64,97	2-carboxylic acid indoles	plasminogen activator inhibitor-1	null	5054	Chemical	Gene	Synthesis|nmod|START_ENTITY Synthesis|nmod|inhibitors inhibitors|nmod|END_ENTITY	Synthesis and SAR of 2-carboxylic_acid_indoles as inhibitors of plasminogen_activator_inhibitor-1 .
24269511	0	2-chloro-4-anilino-quinazoline	6,36	EGFR	52,56	2-chloro-4-anilino-quinazoline	EGFR	null	1956	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Novel 2-chloro-4-anilino-quinazoline derivatives as EGFR and VEGFR-2 dual inhibitors .
22642439	0	2-chloro-5-hydroxyphenylglycine	24,55	mGluR5	66,72	2-chloro-5-hydroxyphenylglycine	mGluR5	MESH:C107349	14805(Tax:10090)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	The orthosteric agonist 2-chloro-5-hydroxyphenylglycine activates mGluR5 and mGluR1 with similar efficacy and potency .
18189232	0	2-chloroadenosine	0,17	PAR-1	28,33	2-chloroadenosine	PAR-1	MESH:D015762	145624	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	2-chloroadenosine modulates PAR-1 and IL-23 expression and enhances docetaxel effects on PC3 cells .
15135110	0	2-chlorodeoxyadenosine	203,225	deoxycytidine_kinase	21,41	2-chlorodeoxyadenosine	deoxycytidine kinase	MESH:D017338	1633	Chemical	Gene	metabolite|nmod|START_ENTITY Identification|nmod|metabolite Determination|dep|Identification Determination|nmod|activity activity|amod|END_ENTITY	Determination of the deoxycytidine_kinase activity in cell homogenates with a non-radiochemical assay using reversed-phase high performance liquid chromatography ; Identification of a novel metabolite of 2-chlorodeoxyadenosine .
7718326	0	2-chlorodeoxyadenosine	58,80	deoxycytidine_kinase	14,34	2-chlorodeoxyadenosine	deoxycytidine kinase	MESH:D017338	1633	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of deoxycytidine_kinase and phosphorylation of 2-chlorodeoxyadenosine in human normal and tumour cells and tissues .
8094016	0	2-chlorodeoxyadenosine	105,127	deoxycytidine_kinase	16,36	2-chlorodeoxyadenosine	deoxycytidine kinase	MESH:D017338	1633	Chemical	Gene	efficacy|nmod|START_ENTITY nucleotidase|nmod|efficacy Relationship|dep|nucleotidase Relationship|nmod|END_ENTITY	Relationship of deoxycytidine_kinase and cytoplasmic 5 ' - nucleotidase to the chemotherapeutic efficacy of 2-chlorodeoxyadenosine .
17724373	0	2-cyano-lup-1-en-3-oxo-20-oic_acid	0,34	peroxisome_proliferator-activated_receptor_gamma	84,132	2-cyano-lup-1-en-3-oxo-20-oic acid	peroxisome proliferator-activated receptor gamma	MESH:C525836	5468	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	2-cyano-lup-1-en-3-oxo-20-oic_acid , a cyano derivative of betulinic_acid , activates peroxisome_proliferator-activated_receptor_gamma in colon_and_pancreatic_cancer cells .
20843687	0	2-cyano-pyrimidine	16,34	cathepsin_K	49,60	2-cyano-pyrimidine	cathepsin K	null	1513	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Optimisation of 2-cyano-pyrimidine inhibitors of cathepsin_K : improving selectivity over hERG .
20149657	0	2-cyano-pyrimidines	45,64	cathepsin_K	68,79	2-cyano-pyrimidines	cathepsin K	null	29175(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Design and optimization of a series of novel 2-cyano-pyrimidines as cathepsin_K inhibitors .
24646893	0	2-cyanoethyl	50,62	p27Kip1	75,82	2-cyanoethyl	p27Kip1	null	1027	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|amod|END_ENTITY	High-throughput screening reveals alsterpaullone , 2-cyanoethyl as a potent p27Kip1 transcriptional inhibitor .
10718520	0	2-deoxy-D-glucose	17,34	Fos	43,46	2-deoxy-D-glucose	Fos	MESH:D003847	2353	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Intraventricular 2-deoxy-D-glucose induces Fos expression by hypothalamic vasopressin , but not oxytocin neurons .
17125738	0	2-deoxy-D-glucose	39,56	HIF-3alpha	25,35	2-deoxy-D-glucose	HIF-3alpha	MESH:D003847	64345(Tax:10116)	Chemical	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	Non-hypoxic induction of HIF-3alpha by 2-deoxy-D-glucose and insulin .
85472	0	2-deoxy-D-glucose	30,47	Nerve_growth_factor	0,19	2-deoxy-D-glucose	Nerve growth factor	MESH:D003847	396466(Tax:9031)	Chemical	Gene	transport|amod|START_ENTITY action|nmod|transport action|amod|END_ENTITY	Nerve_growth_factor action on 2-deoxy-D-glucose transport in dorsal root ganglionic dissociates from chick embryo .
24292700	0	2-deoxy-D-glucose	147,164	PYGB	109,113	2-deoxy-D-glucose	PYGB	MESH:D003847	5834	Chemical	Gene	lines|amod|START_ENTITY END_ENTITY|nmod|lines	Increased sensitivity to glucose starvation correlates with downregulation of glycogen phosphorylase isoform PYGB in tumor cell lines resistant to 2-deoxy-D-glucose .
8750890	0	2-deoxy-D-glucose	51,68	c-fos	95,100	2-deoxy-D-glucose	c-fos	MESH:D003847	314322(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|gene gene|amod|END_ENTITY	Central glucoprivation evoked by administration of 2-deoxy-D-glucose induces expression of the c-fos gene in a subpopulation of neuropeptide_Y neurons in the rat hypothalamus .
6764708	0	2-deoxy-D-glucose	94,111	gastrin	48,55	2-deoxy-D-glucose	gastrin	MESH:D003847	2520	Chemical	Gene	administration|amod|START_ENTITY levels|nmod|administration levels|compound|END_ENTITY	Gastric_acid secretion and the changes of blood gastrin , glucose and insulin levels following 2-deoxy-D-glucose administration in hypersecretory and normosecretory duodenal ulcer patients .
2136308	0	2-deoxy-D-glucose	18,35	glucose-6-phosphate_dehydrogenase	39,72	2-deoxy-D-glucose	glucose-6-phosphate dehydrogenase	MESH:D003847	24377(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	In vivo effect of 2-deoxy-D-glucose on glucose-6-phosphate_dehydrogenase activity in the cytosol of liver , heart and skeletal muscle of rats .
400718	0	2-deoxy-D-glucose	64,81	pancreatic_polypeptide	15,37	2-deoxy-D-glucose	pancreatic polypeptide	MESH:D003847	5539	Chemical	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Stimulation of pancreatic_polypeptide and glucagon secretion by 2-deoxy-D-glucose in man : evidence for cholinergic mediation .
10718520	0	2-deoxy-D-glucose	17,34	vasopressin	74,85	2-deoxy-D-glucose	vasopressin	MESH:D003847	551	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Intraventricular 2-deoxy-D-glucose induces Fos expression by hypothalamic vasopressin , but not oxytocin neurons .
7637890	0	2-deoxy-D-glucose	93,110	vasopressin	22,33	2-deoxy-D-glucose	vasopressin	MESH:D003847	551	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Suppressive effect of vasopressin on the hyperglycemic response to intracranial injection of 2-deoxy-D-glucose .
19574224	0	2-deoxyglucose	25,39	IGF1R	88,93	2-deoxyglucose	IGF1R	MESH:D003847	3480	Chemical	Gene	activates|nsubj|START_ENTITY activates|nmod|END_ENTITY	The glycolytic inhibitor 2-deoxyglucose activates multiple prosurvival pathways through IGF1R .
21604001	0	2-deoxyglucose	11,25	SIRT1	84,89	2-deoxyglucose	SIRT1	MESH:D003847	23411	Chemical	Gene	activity|amod|START_ENTITY activity|dep|END_ENTITY	Effects of 2-deoxyglucose and dehydroepiandrosterone on intracellular NAD -LRB- + -RRB- level , SIRT1 activity and replicative lifespan of human Hs68 cells .
2425861	0	2-deoxyglucose	60,74	insulin	16,23	2-deoxyglucose	insulin	MESH:D003847	3630	Chemical	Gene	transport|amod|START_ENTITY stimulation|nmod|transport binding|nmod|stimulation binding|nsubj|Dissociation Dissociation|nmod|END_ENTITY	Dissociation of insulin binding from insulin stimulation of 2-deoxyglucose transport by ruthenium red .
2425861	0	2-deoxyglucose	60,74	insulin	37,44	2-deoxyglucose	insulin	MESH:D003847	3630	Chemical	Gene	transport|amod|START_ENTITY stimulation|nmod|transport stimulation|compound|END_ENTITY	Dissociation of insulin binding from insulin stimulation of 2-deoxyglucose transport by ruthenium red .
3539675	0	2-deoxyglucose	32,46	insulin	14,21	2-deoxyglucose	insulin	MESH:D003847	396145(Tax:9031)	Chemical	Gene	uptake|amod|START_ENTITY action|nmod|uptake action|compound|END_ENTITY	Modulation of insulin action on 2-deoxyglucose uptake by chloroquine in chick embryo fibroblasts .
7011740	0	2-deoxyglucose	61,75	insulin	50,57	2-deoxyglucose	insulin	MESH:D003847	3630	Chemical	Gene	transport|amod|START_ENTITY END_ENTITY|nmod|transport	Receptor binding and effect of biosynthetic human insulin on 2-deoxyglucose transport .
7033268	0	2-deoxyglucose	95,109	insulin	23,30	2-deoxyglucose	insulin	MESH:D003847	3630	Chemical	Gene	uptake|amod|START_ENTITY stimulation|nmod|uptake levels|dep|stimulation enhancement|dep|levels enhancement|nmod|action action|compound|END_ENTITY	Glucose enhancement of insulin action : elevated glucose levels increase insulin stimulation of 2-deoxyglucose uptake in cultured human fibroblasts .
7033268	0	2-deoxyglucose	95,109	insulin	72,79	2-deoxyglucose	insulin	MESH:D003847	3630	Chemical	Gene	uptake|amod|START_ENTITY stimulation|nmod|uptake stimulation|compound|END_ENTITY	Glucose enhancement of insulin action : elevated glucose levels increase insulin stimulation of 2-deoxyglucose uptake in cultured human fibroblasts .
8095464	0	2-deoxyglucose	16,30	somatostatin	78,90	2-deoxyglucose	somatostatin	MESH:D003847	24797(Tax:10116)	Chemical	Gene	uptake|amod|START_ENTITY uptake|nmod|END_ENTITY	Facilitation of 2-deoxyglucose uptake in rat cortex and hippocampus slices by somatostatin is independent of cholinergic activity .
14976230	0	2-furoyl-LIGRLO-amide	0,21	proteinase-activated_receptor_2	46,77	2-furoyl-LIGRLO-amide	proteinase-activated receptor 2	MESH:C487404	2150	Chemical	Gene	START_ENTITY|dep|agonist agonist|amod|END_ENTITY	2-furoyl-LIGRLO-amide : a potent and selective proteinase-activated_receptor_2 agonist .
26547230	0	2-hydroxy-3-oxoadipate	107,129	rv1248c	89,96	2-hydroxy-3-oxoadipate	rv1248c	CHEBI:16278	887084(Tax:83332)	Chemical	Gene	synthase|amod|START_ENTITY synthase|amod|END_ENTITY	Comparison of transposon and deletion mutants in Mycobacterium_tuberculosis : The case of rv1248c , encoding 2-hydroxy-3-oxoadipate synthase .
14741268	0	2-hydroxy-4-isopropylbenzaldehyde	0,33	tyrosinase	52,62	2-hydroxy-4-isopropylbenzaldehyde	tyrosinase	null	7299	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	2-hydroxy-4-isopropylbenzaldehyde , a potent partial tyrosinase inhibitor .
17383874	0	2-hydroxy-N-arylbenzenesulfonamides	0,35	ATP-citrate_lyase	39,56	2-hydroxy-N-arylbenzenesulfonamides	ATP-citrate lyase	null	104112(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	2-hydroxy-N-arylbenzenesulfonamides as ATP-citrate_lyase inhibitors .
21562890	0	2-hydroxy-ethyl_methacrylate	64,92	Translationally_controlled_tumor_protein	0,40	2-hydroxy-ethyl methacrylate	Translationally controlled tumor protein	MESH:C005044	7178	Chemical	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	Translationally_controlled_tumor_protein against apoptosis from 2-hydroxy-ethyl_methacrylate in human dental pulp cells .
10684930	0	2-hydroxyadenine	67,83	hMYH	126,130	2-hydroxyadenine	hMYH	MESH:C008183	4595	Chemical	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of human MutY homolog -LRB- hMYH -RRB- as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria .
23414802	0	2-hydroxydiarylamide	19,39	TMPRSS4	55,62	2-hydroxydiarylamide	TMPRSS4	null	56649	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Discovery of novel 2-hydroxydiarylamide derivatives as TMPRSS4 inhibitors .
3139939	0	2-hydroxyestradiol	13,31	tyrosinase	79,89	2-hydroxyestradiol	tyrosinase	MESH:C001390	7299	Chemical	Gene	Oxidation|nmod|START_ENTITY Oxidation|nmod|END_ENTITY	Oxidation of 2-hydroxyestradiol and its incorporation into melanin by mushroom tyrosinase .
6430238	0	2-hydroxyestradiol	53,71	tyrosinase	24,34	2-hydroxyestradiol	tyrosinase	MESH:C001390	7299	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The catalytic effect of tyrosinase upon oxidation of 2-hydroxyestradiol in presence of catechol .
6631152	0	2-hydroxyestrone	20,36	catechol-O-methyltransferase	53,81	2-hydroxyestrone	catechol-O-methyltransferase	MESH:C024980	1312	Chemical	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	-LSB- Serum unconjugated 2-hydroxyestrone and erythrocyte catechol-O-methyltransferase activity in pregnancy_toxemia -RSB- .
7109588	0	2-hydroxyethynyloestradiol	0,26	catechol-O-methyltransferase	46,74	2-hydroxyethynyloestradiol	catechol-O-methyltransferase	null	24267(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|substrate substrate|nmod|END_ENTITY	2-hydroxyethynyloestradiol as a substrate for catechol-O-methyltransferase -- implications in the metabolism of ethynyloestradiol .
23113830	0	2-hydroxyflutamide	34,52	androgen_receptor	60,77	2-hydroxyflutamide	androgen receptor	MESH:C014290	397582(Tax:9823)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	The influence of the antiandrogen 2-hydroxyflutamide on the androgen_receptor expression in the porcine ovarian follicles - an in vitro study .
9605422	0	2-imidazolyl_disulfides	78,101	thioredoxin	32,43	2-imidazolyl disulfides	thioredoxin	null	7295	Chemical	Gene	system|nmod|START_ENTITY system|amod|END_ENTITY	Mechanisms of inhibition of the thioredoxin growth factor system by antitumor 2-imidazolyl_disulfides .
8576908	0	2-iminoazaheterocycles	28,50	nitric_oxide_synthase	81,102	2-iminoazaheterocycles	nitric oxide synthase	null	4843	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	2-Iminopiperidine and other 2-iminoazaheterocycles as potent inhibitors of human nitric_oxide_synthase isoforms .
10433493	0	2-indolyl_methylamines	32,54	MAO-B	72,77	2-indolyl methylamines	MAO-B	null	4129	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|amod|END_ENTITY	Relevance of benzyloxy group in 2-indolyl_methylamines in the selective MAO-B inhibition .
17694563	0	2-isopropoxynaphthoquinone	79,105	ecdysone_20-monooxygenase	109,134	2-isopropoxynaphthoquinone	ecdysone 20-monooxygenase	MESH:C528195	39592(Tax:7227)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effects of the compounds 2-methoxynaphthoquinone , 2-propoxynaphthoquinone , and 2-isopropoxynaphthoquinone on ecdysone_20-monooxygenase activity .
22196515	0	2-keto-oxazole	64,78	FAAH	93,97	2-keto-oxazole	FAAH	null	2166	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Design , synthesis and evaluation of polar head group containing 2-keto-oxazole inhibitors of FAAH .
3260576	0	2-mercaptoethanol	54,71	interleukin_2	75,88	2-mercaptoethanol	interleukin 2	MESH:D008623	16183(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	The role of thiols in lymphocyte responses : effect of 2-mercaptoethanol on interleukin_2 production .
19556125	0	2-mercaptohexanoic_acid	30,53	PPARalpha	83,92	2-mercaptohexanoic acid	PPARalpha	null	5465	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Discovery of a novel class of 2-mercaptohexanoic_acid derivatives as highly active PPARalpha agonists .
22841436	0	2-methoxyacylhydrazones	6,29	PDE10A	51,57	2-methoxyacylhydrazones	PDE10A	null	10846	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Novel 2-methoxyacylhydrazones as potent , selective PDE10A inhibitors with activity in animal models of schizophrenia .
17716391	0	2-methoxyestradiol	14,32	HIF-1_alpha	36,47	2-methoxyestradiol	HIF-1 alpha	MESH:C022830	29560(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	The effect of 2-methoxyestradiol , a HIF-1_alpha inhibitor , in global cerebral_ischemia in rats .
27082496	0	2-methoxyestradiol	21,39	HIF-1a	0,6	2-methoxyestradiol	HIF-1a	MESH:C022830	3091	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	HIF-1a inhibition by 2-methoxyestradiol induces cell death via activation of the mitochondrial apoptotic pathway in acute_myeloid_leukemia .
19379562	0	2-methoxyestradiol	12,30	caspase-3	52,61	2-methoxyestradiol	caspase-3	MESH:C022830	836	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of 2-methoxyestradiol on the expression of caspase-3 and survivin in chronic_myelocytic_leukemia K562 cells -RSB- .
22095881	0	2-methoxyestradiol	11,29	cyclin_B1	81,90	2-methoxyestradiol	cyclin B1	MESH:C022830	891	Chemical	Gene	expression|amod|START_ENTITY Effects|nmod|expression Effects|nmod|END_ENTITY	Effects of 2-methoxyestradiol on proliferation , apoptosis and gene expression of cyclin_B1 and c-Myc in esophageal_carcinoma EC9706 cells .
12543804	0	2-methoxyestradiol	0,18	death_receptor_5	32,48	2-methoxyestradiol	death receptor 5	MESH:C022830	8795	Chemical	Gene	up-regulates|amod|START_ENTITY END_ENTITY|nsubj|up-regulates	2-methoxyestradiol up-regulates death_receptor_5 and induces apoptosis through activation of the extrinsic pathway .
16033134	0	2-methoxyestradiol	22,40	death_receptor_5	85,101	2-methoxyestradiol	death receptor 5	MESH:C022830	8795	Chemical	Gene	incubation|nmod|START_ENTITY kills|nsubj|incubation kills|xcomp|independent independent|nmod|upregulation upregulation|amod|END_ENTITY	Short incubation with 2-methoxyestradiol kills malignant_glioma cells independent of death_receptor_5 upregulation .
12228253	0	2-methoxyestradiol	72,90	sex_hormone-binding_globulin	27,55	2-methoxyestradiol	sex hormone-binding globulin	MESH:C022830	6462	Chemical	Gene	complex|nmod|START_ENTITY END_ENTITY|nmod|complex	Crystal structure of human sex_hormone-binding_globulin in complex with 2-methoxyestradiol reveals the molecular basis for high affinity interactions with C-2 derivatives of estradiol .
23233290	0	2-methoxyoestradiol	0,19	catechol-O-methyltransferase	41,69	2-methoxyoestradiol	catechol-O-methyltransferase	MESH:C530369	1312	Chemical	Gene	levels|amod|START_ENTITY END_ENTITY|nsubj|levels	2-methoxyoestradiol levels and placental catechol-O-methyltransferase expression in patients with late-onset preeclampsia .
18299970	0	2-nitro-5-thiosulfobenzoic_acid	0,31	deoxyribonuclease_I	66,85	2-nitro-5-thiosulfobenzoic acid	deoxyribonuclease I	MESH:C041724	25633(Tax:10116)	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	2-nitro-5-thiosulfobenzoic_acid as a novel inhibitor specific for deoxyribonuclease_I .
3191566	0	2-nitrofluorene	86,101	cytochrome_P-450b	28,45	2-nitrofluorene	cytochrome P-450b	MESH:C019499	24300(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Age dependent expression of cytochrome_P-450b and metabolism of the potent carcinogen 2-nitrofluorene in the rat lung .
23741428	0	2-octynoic_acid	0,15	AMP-activated_protein_kinase	75,103	2-octynoic acid	AMP-activated protein kinase	MESH:C060855	5563	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|activation activation|nmod|END_ENTITY	2-octynoic_acid inhibits hepatitis_C_virus_infection through activation of AMP-activated_protein_kinase .
12098254	0	2-oxonia	90,98	Cope	99,103	2-oxonia	Cope	null	11316	Chemical	Gene	rearrangement|amod|START_ENTITY rearrangement|compound|END_ENTITY	Stereocontrolled synthesis of linear_22R-homoallylic_sterols via a triflic_acid-catalyzed 2-oxonia Cope rearrangement .
3632710	0	2-phenyl-3-haloallylamines	65,91	semicarbazide-sensitive_amine_oxidase	24,61	2-phenyl-3-haloallylamines	semicarbazide-sensitive amine oxidase	null	29473(Tax:10116)	Chemical	Gene	compounds|amod|START_ENTITY END_ENTITY|nmod|compounds	Inhibition of rat aorta semicarbazide-sensitive_amine_oxidase by 2-phenyl-3-haloallylamines and related compounds .
10443017	0	2-phenyl-4-quinolinecarboxamide	39,70	NK-3_receptor	71,84	2-phenyl-4-quinolinecarboxamide	NK-3 receptor	null	6870	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|compound|END_ENTITY	Replacement of the quinoline system in 2-phenyl-4-quinolinecarboxamide NK-3_receptor antagonists .
21413799	0	2-phenyl-5-trifluoromethyloxazole-4-carboxamide	58,105	diacylglycerol_acyltransferase-1	116,148	2-phenyl-5-trifluoromethyloxazole-4-carboxamide	diacylglycerol acyltransferase-1	null	84497(Tax:10116)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Discovery of orally active carboxylic_acid derivatives of 2-phenyl-5-trifluoromethyloxazole-4-carboxamide as potent diacylglycerol_acyltransferase-1 inhibitors for the potential treatment of obesity and diabetes .
15341953	0	2-phenyl-benzofurans	14,34	ER_beta	38,45	2-phenyl-benzofurans	ER beta	null	2100	Chemical	Gene	START_ENTITY|nmod|ligands ligands|compound|END_ENTITY	7-Substituted 2-phenyl-benzofurans as ER_beta selective ligands .
6173517	0	2-phenylaminoadenosine	10,32	CV-1808	34,41	2-phenylaminoadenosine	CV-1808	MESH:C026708	2550163(Tax:243365)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of 2-phenylaminoadenosine -LRB- CV-1808 -RRB- on ischemic ST-segment elevation in anesthetized dogs .
20650544	0	2-phenylethanol	133,148	phenylacetaldehyde_reductase	36,64	2-phenylethanol	phenylacetaldehyde reductase	MESH:D010626	100134901(Tax:4081)	Chemical	Gene	biosynthesis|nmod|START_ENTITY involved|nmod|biosynthesis enzyme|acl|involved END_ENTITY|appos|enzyme	Functional characterization of rose phenylacetaldehyde_reductase -LRB- PAR -RRB- , an enzyme involved in the biosynthesis of the scent compound 2-phenylethanol .
1601056	0	2-phenylethylamine	11,29	monoamine_oxidase	44,61	2-phenylethylamine	monoamine oxidase	MESH:C029261	29253(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|amod|END_ENTITY	Absence of 2-phenylethylamine binding after monoamine_oxidase inhibition in rat brain .
23868063	0	2-phenylethynesulfonamide	20,45	HSP70	0,5	2-phenylethynesulfonamide	HSP70	null	3308	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nummod|END_ENTITY	HSP70 inhibition by 2-phenylethynesulfonamide induces lysosomal cathepsin_D release and immunogenic cell death in primary effusion_lymphoma .
14980690	0	2-phenylspiroindenediones	39,64	estrogen_receptor	68,85	2-phenylspiroindenediones	estrogen receptor	null	2099	Chemical	Gene	START_ENTITY|nmod|ligands ligands|compound|END_ENTITY	Comparison of 2-phenylspiroindenes and 2-phenylspiroindenediones as estrogen_receptor ligands -- modeling and binding data do n't agree !
24871899	0	2-phenylthiomethyl-indole	102,127	5-lipoxygenase	173,187	2-phenylthiomethyl-indole	5-lipoxygenase	null	240	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|inhibitors inhibitors|nmod|END_ENTITY	Further studies on ethyl_5-hydroxy-indole-3-carboxylate scaffold : design , synthesis and evaluation of 2-phenylthiomethyl-indole derivatives as efficient inhibitors of human 5-lipoxygenase .
17478634	0	2-phosphoglycolate	39,57	PGLP1	71,76	2-phosphoglycolate	PGLP1	CHEBI:17150	833635(Tax:3702)	Chemical	Gene	phosphatase|amod|START_ENTITY phosphatase|appos|END_ENTITY	Identification of the photorespiratory 2-phosphoglycolate phosphatase , PGLP1 , in Arabidopsis .
24435491	0	2-phosphoglycollate	60,79	phosphoenolpyruvate_carboxylase	14,45	2-phosphoglycollate	phosphoenolpyruvate carboxylase	null	100101511(Tax:4577)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of phosphoenolpyruvate_carboxylase from maize by 2-phosphoglycollate .
16403497	0	2-phosphonomethyl-pentanedioic_acid	0,35	glutamate_carboxypeptidase_II	37,66	2-phosphonomethyl-pentanedioic acid	glutamate carboxypeptidase II	MESH:C402107	53320(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	2-phosphonomethyl-pentanedioic_acid -LRB- glutamate_carboxypeptidase_II inhibitor -RRB- increases threshold for electroconvulsions and enhances the antiseizure action of valproate against maximal electroshock-induced seizures in mice .
19500979	0	2-piperidin-4-yl-acetamides	16,43	melanin-concentrating_hormone_receptor_1	47,87	2-piperidin-4-yl-acetamides	melanin-concentrating hormone receptor 1	null	2847	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|amod|END_ENTITY	Optimization of 2-piperidin-4-yl-acetamides as melanin-concentrating_hormone_receptor_1 -LRB- MCH-R1 -RRB- antagonists : Designing out hERG inhibition .
10544801	0	2-propanol	66,76	prophenoloxidase	44,60	2-propanol	prophenoloxidase	MESH:D019840	37044(Tax:7227)	Chemical	Gene	generated|nmod|START_ENTITY generated|nmod|END_ENTITY	Properties of phenoloxidases generated from prophenoloxidase with 2-propanol and the natural activator in Drosophila_melanogaster .
8508190	0	2-propanol	36,46	prophenoloxidase	14,30	2-propanol	prophenoloxidase	MESH:D019840	37044(Tax:7227)	Chemical	Gene	compounds|amod|START_ENTITY Activation|nmod|compounds Activation|nmod|END_ENTITY	Activation of prophenoloxidase with 2-propanol and other organic compounds in Drosophila_melanogaster .
9723163	0	2-propanol	47,57	prophenoloxidase	25,41	2-propanol	prophenoloxidase	MESH:D019840	37044(Tax:7227)	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Reversible activation of prophenoloxidase with 2-propanol in Drosophila_melanogaster .
1772533	1	2-propylpentylglycinamide	80,105	monoamine_oxidase_B	109,128	2-propylpentylglycinamide	monoamine oxidase B	null	25750(Tax:10116)	Chemical	Gene	Deamination|nmod|START_ENTITY Deamination|nmod|END_ENTITY	Deamination of 2-propylpentylglycinamide by monoamine_oxidase_B .
8481010	1	2-propylphenol	63,77	Prp	41,44	2-propylphenol	Prp	MESH:C080638	5621	Chemical	Gene	metabolism|nmod|START_ENTITY END_ENTITY|nmod|metabolism	strain HBP1 Prp for metabolism of 2-propylphenol and elucidation of the degradative pathway .
25203462	0	2-pyridylureas	13,27	glucokinase	31,42	2-pyridylureas	glucokinase	null	103988(Tax:10090)	Chemical	Gene	activators|amod|START_ENTITY activators|amod|END_ENTITY	Discovery of 2-pyridylureas as glucokinase activators .
21087014	0	2-quinolinecarboxamide	21,43	translocator_protein	59,79	2-quinolinecarboxamide	translocator protein	MESH:C530252	706	Chemical	Gene	ligands|amod|START_ENTITY ligands|nmod|END_ENTITY	Carborane-conjugated 2-quinolinecarboxamide ligands of the translocator_protein for boron neutron capture therapy .
2104936	0	2-substituted-1-naphthols	0,25	5-lipoxygenase	36,50	2-substituted-1-naphthols	5-lipoxygenase	null	25290(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	2-substituted-1-naphthols as potent 5-lipoxygenase inhibitors with topical antiinflammatory activity .
21599857	0	2-substituted_5-hydroxyindole-3-carboxylates	65,109	5-lipoxygenase	20,34	2-substituted 5-hydroxyindole-3-carboxylates	5-lipoxygenase	null	240	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Exploring QSARs for 5-lipoxygenase -LRB- 5-LO -RRB- inhibitory activity of 2-substituted_5-hydroxyindole-3-carboxylates by CoMFA and CoMSIA .
26373204	0	2-substituted_ethenesulfonic_acid_ester	48,87	PTP1B	113,118	2-substituted ethenesulfonic acid ester	PTP1B	null	5770	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|inhibitors inhibitors|compound|END_ENTITY	Design , synthesis , and biological evaluation of 2-substituted_ethenesulfonic_acid_ester derivatives as selective PTP1B inhibitors .
19090923	0	2-sulfonyl-phenyl-indol	31,54	COX-2	91,96	2-sulfonyl-phenyl-indol	COX-2	null	4513	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Exploring QSAR for substituted 2-sulfonyl-phenyl-indol derivatives as potent and selective COX-2 inhibitors using different chemometrics tools .
23530754	0	2-thiazolidinones	33,50	BRD4	87,91	2-thiazolidinones	BRD4	null	23476	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Fragment-based drug discovery of 2-thiazolidinones as inhibitors of the histone reader BRD4 bromodomain .
22222137	0	2-thiazolylhydrazones	45,66	monoamine_oxidase_B	118,137	2-thiazolylhydrazones	monoamine oxidase B	null	4129	Chemical	Gene	assessment|nmod|START_ENTITY assessment|nmod|END_ENTITY	Synthesis and biological assessment of novel 2-thiazolylhydrazones and computational analysis of their recognition by monoamine_oxidase_B .
24320749	0	2-thioxanthine	34,48	myeloperoxidase	49,64	2-thioxanthine	myeloperoxidase	null	4353	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	Mechanistic characterization of a 2-thioxanthine myeloperoxidase inhibitor and selectivity assessment utilizing click chemistry -- activity-based protein profiling .
25818766	0	2-thioxo-4-thiazolidinone	57,82	Bcl-2	98,103	2-thioxo-4-thiazolidinone	Bcl-2	null	596	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Design , synthesis and preliminary bioactivity studies of 2-thioxo-4-thiazolidinone derivatives as Bcl-2 inhibitors .
23104236	0	20-HETE	24,31	NKCC2	49,54	20-HETE	NKCC2	MESH:C055987	20495(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|protein protein|compound|END_ENTITY	Synergistical effect of 20-HETE and high salt on NKCC2 protein and blood pressure via ubiquitin-proteasome pathway .
17894557	0	20-Hydroxyecdysone	0,18	E74	78,81	20-Hydroxyecdysone	E74	MESH:D004441	693011(Tax:7091)	Chemical	Gene	regulation|amod|START_ENTITY END_ENTITY|nsubj|regulation	20-Hydroxyecdysone regulation of two isoforms of the Ets transcription factor E74 gene in programmed cell death in the silkworm anterior silk gland .
8606006	0	20-Hydroxyecdysone	0,18	yolk_protein	60,72	20-Hydroxyecdysone	yolk protein	MESH:D004441	31939(Tax:7227)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	20-Hydroxyecdysone , but not juvenile_hormone , regulation of yolk_protein gene expression can be mapped to cis-acting DNA sequences .
21323895	0	20-Hydroxyeicosatetraenoic_acid	0,31	COX-2	53,58	20-Hydroxyeicosatetraenoic acid	COX-2	MESH:C055987	5743	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	20-Hydroxyeicosatetraenoic_acid inhibits ATP-induced COX-2 expression via peroxisome proliferator activator receptor-a in vascular smooth muscle cells .
24324797	0	20-Hydroxyeicosatetraenoic_acid	0,31	angiotensin_II	117,131	20-Hydroxyeicosatetraenoic acid	angiotensin II	MESH:C055987	24179(Tax:10116)	Chemical	Gene	contributes|nsubj|START_ENTITY contributes|nmod|END_ENTITY	20-Hydroxyeicosatetraenoic_acid contributes to the inhibition of K + channel activity and vasoconstrictor response to angiotensin_II in rat renal microvessels .
16713008	0	20-Hydroxyeicosatetraenoic_acid	0,31	insulin	67,74	20-Hydroxyeicosatetraenoic acid	insulin	MESH:C055987	3630	Chemical	Gene	associated|nsubjpass|START_ENTITY associated|advcl|circulating circulating|dobj|END_ENTITY	20-Hydroxyeicosatetraenoic_acid is not associated with circulating insulin in lean to overweight humans .
3025658	0	20-OH-ecdysone	61,75	DOPA_decarboxylase	27,45	20-OH-ecdysone	DOPA decarboxylase	CHEBI:16587	35190(Tax:7227)	Chemical	Gene	subline|amod|START_ENTITY Modulation|nmod|subline Modulation|nmod|transcripts transcripts|compound|END_ENTITY	Modulation of novel-length DOPA_decarboxylase transcripts by 20-OH-ecdysone in a Drosophila_melanogaster Kc cell subline .
2507336	0	20-OH-ecdysone	0,14	beta_tubulin	30,42	20-OH-ecdysone	beta tubulin	CHEBI:16587	37888(Tax:7227)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	20-OH-ecdysone regulates 60 C beta_tubulin gene expression in Kc cells and during Drosophila development .
3007239	0	20-OH-ecdysone	57,71	dopa_decarboxylase	30,48	20-OH-ecdysone	dopa decarboxylase	CHEBI:16587	35190(Tax:7227)	Chemical	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Differential responses of the dopa_decarboxylase gene to 20-OH-ecdysone in Drosophila_melanogaster .
17570489	0	20-hydroxyecdysone	75,93	juvenile_hormone_esterase	30,55	20-hydroxyecdysone	juvenile hormone esterase	MESH:D004441	692579(Tax:7091)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Tissue-specific regulation of juvenile_hormone_esterase gene expression by 20-hydroxyecdysone and juvenile_hormone in Bombyx_mori .
12069931	0	20-hydroxyeicosatetraenoic_acid	8,39	angiotensin_II	84,98	20-hydroxyeicosatetraenoic acid	angiotensin II	MESH:C055987	24179(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of 20-hydroxyeicosatetraenoic_acid in the renal and vasoconstrictor actions of angiotensin_II .
26970587	0	20-hydroxyvitamin_D3	17,37	CYP3A4	47,53	20-hydroxyvitamin D3	CYP3A4	MESH:C480634	1576	Chemical	Gene	Hydroxylation|nmod|START_ENTITY Hydroxylation|nmod|END_ENTITY	Hydroxylation of 20-hydroxyvitamin_D3 by human CYP3A4 .
19291609	0	20S-protopanaxadiol	0,19	P-glycoprotein	29,43	20S-protopanaxadiol	P-glycoprotein	MESH:C062916	67078(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	20S-protopanaxadiol inhibits P-glycoprotein in multidrug resistant cancer cells .
20727920	0	20a-hydroxysteroid	6,24	AKR1C1	40,46	20a-hydroxysteroid	AKR1C1	null	1645	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	Human 20a-hydroxysteroid dehydrogenase -LRB- AKR1C1 -RRB- - dependent biotransformation with recombinant fission_yeast Schizosaccharomyces_pombe .
21050889	0	20a-hydroxysteroid	20,38	AKR1C1	54,60	20a-hydroxysteroid	AKR1C1	null	1645	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	Inhibitors of human 20a-hydroxysteroid dehydrogenase -LRB- AKR1C1 -RRB- .
21414777	0	20a-hydroxysteroid	50,68	AKR1C1	84,90	20a-hydroxysteroid	AKR1C1	null	1645	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	Probing the inhibitor selectivity pocket of human 20a-hydroxysteroid dehydrogenase -LRB- AKR1C1 -RRB- with X-ray crystallography and site-directed mutagenesis .
9507127	0	20beta-hydroxy-C21-steroid	0,26	cytochrome_P450c21	54,72	20beta-hydroxy-C21-steroid	cytochrome P450c21	null	281741(Tax:9913)	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	20beta-hydroxy-C21-steroid 20beta-oxidase activity of cytochrome_P450c21 purified from bovine adrenocortical microsomes .
12937223	0	22-oxacalcitriol	34,50	parathyroid_hormone	62,81	22-oxacalcitriol	parathyroid hormone	MESH:C051883	24694(Tax:10116)	Chemical	Gene	suppresses|amod|START_ENTITY END_ENTITY|nsubj|suppresses	In subtotally nephrectomized rats 22-oxacalcitriol suppresses parathyroid_hormone with less risk of cardiovascular_calcification or deterioration of residual renal function than 1,25 -LRB- OH -RRB- 2_vitamin_D3 .
11013305	0	24-hydroxycholesterol	0,21	cholesterol_7alpha-hydroxylase	49,79	24-hydroxycholesterol	cholesterol 7alpha-hydroxylase	MESH:C044563	448985(Tax:9823)	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	24-hydroxycholesterol is a substrate for hepatic cholesterol_7alpha-hydroxylase -LRB- CYP7A -RRB- .
17364953	0	25-Hydroxycholesterol	0,21	interleukin-8	81,94	25-Hydroxycholesterol	interleukin-8	MESH:C007997	3576	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	25-Hydroxycholesterol , 7beta-hydroxycholesterol and 7-ketocholesterol upregulate interleukin-8 expression independently of Toll-like_receptor_1 , _ 2 , _ 4_or_6 signalling in human macrophages .
11737865	0	25-OH-cholesterol	60,77	c-jun	86,91	25-OH-cholesterol	c-jun	null	3725	Chemical	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Peroxisome proliferator-activated receptor agonists prevent 25-OH-cholesterol induced c-jun activation and cell death .
867174	0	25-hydroxycholecalciferol	16,41	aid	58,61	25-hydroxycholecalciferol	aid	MESH:D002112	57379	Chemical	Gene	levels|nmod|START_ENTITY levels|nmod|END_ENTITY	Serum levels of 25-hydroxycholecalciferol as a diagnostic aid in vitamin_D deficiency states .
744925	0	25-hydroxycholecalciferol	46,71	growth_hormone	10,24	25-hydroxycholecalciferol	growth hormone	MESH:D002112	81668(Tax:10116)	Chemical	Gene	metabolism|nmod|START_ENTITY Effect|nmod|metabolism Effect|nmod|END_ENTITY	Effect of growth_hormone on the metabolism of 25-hydroxycholecalciferol in hypophysectomized rats on a diet without vitamin_D and low in calcium .
17161435	0	25-hydroxycholesterol	55,76	skeletal_muscle_LIM_protein_1	17,46	25-hydroxycholesterol	skeletal muscle LIM protein 1	MESH:C007997	25177(Tax:10116)	Chemical	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Up-regulation of skeletal_muscle_LIM_protein_1 gene by 25-hydroxycholesterol may mediate morphological changes of rat aortic smooth muscle cells .
23781303	0	25-hydroxyvitamin_D	6,25	B-type_natriuretic_peptide	72,98	25-hydroxyvitamin D	B-type natriuretic peptide	MESH:C104450	4879	Chemical	Gene	START_ENTITY|nmod|relation relation|nmod|END_ENTITY	Serum 25-hydroxyvitamin_D and parathyroid hormone in relation to plasma B-type_natriuretic_peptide : the Hoorn Study .
15947108	0	25-hydroxyvitamin_D	71,90	CYP27B1	112,119	25-hydroxyvitamin D	CYP27B1	MESH:C104450	1594	Chemical	Gene	hydroxylase|amod|START_ENTITY hydroxylase|appos|END_ENTITY	Identification of growth_factor_independent-1 -LRB- GFI1 -RRB- as a repressor of 25-hydroxyvitamin_D 1-alpha hydroxylase -LRB- CYP27B1 -RRB- gene expression in human prostate_cancer cells .
25493954	0	25-hydroxyvitamin_D	31,50	Janus_kinase_3	0,14	25-hydroxyvitamin D	Janus kinase 3	MESH:C104450	16453(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Janus_kinase_3 regulates renal 25-hydroxyvitamin_D 1a-hydroxylase expression , calcitriol formation , and phosphate metabolism .
19111635	0	25-hydroxyvitamin_D	6,25	PTH	64,67	25-hydroxyvitamin D	PTH	MESH:C104450	5741	Chemical	Gene	START_ENTITY|nmod|determinant determinant|nmod|END_ENTITY	Serum 25-hydroxyvitamin_D as an independent determinant of 1-84 PTH and bone_mineral_density in non-diabetic predialysis CKD patients .
23036072	0	25-hydroxyvitamin_D	22,41	PTH	59,62	25-hydroxyvitamin D	PTH	MESH:C104450	5741	Chemical	Gene	START_ENTITY|advcl|circulating circulating|dobj|END_ENTITY	Associations of serum 25-hydroxyvitamin_D with circulating PTH , phosphate and calcium in patients with primary_hyperparathyroidism .
17440943	0	25-hydroxyvitamin_D	85,104	Vitamin_D_receptor	0,18	25-hydroxyvitamin D	Vitamin D receptor	MESH:C104450	7421	Chemical	Gene	plasma|nummod|START_ENTITY interactions|nmod|plasma interactions|nsubj|END_ENTITY	Vitamin_D_receptor -LRB- VDR -RRB- gene polymorphisms and haplotypes , interactions with plasma 25-hydroxyvitamin_D and 1,25-dihydroxyvitamin _ D , and prostate_cancer risk .
23849224	0	25-hydroxyvitamin_D	73,92	Vitamin_D_receptor	0,18	25-hydroxyvitamin D	Vitamin D receptor	MESH:C104450	7421	Chemical	Gene	levels|amod|START_ENTITY serum|dobj|levels relationship|acl|serum ChIP-seq|dep|relationship ChIP-seq|compound|END_ENTITY	Vitamin_D_receptor ChIP-seq in primary CD4 + cells : relationship to serum 25-hydroxyvitamin_D levels and autoimmune_disease .
25224407	0	25-hydroxyvitamin_D	69,88	Vitamin_D_receptor	0,18	25-hydroxyvitamin D	Vitamin D receptor	MESH:C104450	7421	Chemical	Gene	levels|amod|START_ENTITY relation|nmod|levels polymorphisms|nmod|relation polymorphisms|amod|END_ENTITY	Vitamin_D_receptor gene polymorphisms -LRB- TaqI and ApaI -RRB- in relation to 25-hydroxyvitamin_D levels and coronary_artery_disease incidence .
22729969	0	25-hydroxyvitamin_D	16,35	insulin	66,73	25-hydroxyvitamin D	insulin	MESH:C104450	3630	Chemical	Gene	Associations|nmod|START_ENTITY fasting|nsubj|Associations fasting|dobj|END_ENTITY	Associations of 25-hydroxyvitamin_D with fasting glucose , fasting insulin , dementia and depression in European elderly : the SENECA study .
23093338	0	25-hydroxyvitamin_D	6,25	insulin	41,48	25-hydroxyvitamin D	insulin	MESH:C104450	3630	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	Serum 25-hydroxyvitamin_D and markers of insulin resistance in a Japanese working population .
23674796	0	25-hydroxyvitamin_D	108,127	insulin	68,75	25-hydroxyvitamin D	insulin	MESH:C104450	3630	Chemical	Gene	continuum|amod|START_ENTITY region|nmod|continuum localizes|nmod|region localizes|dobj|association association|nmod|status status|nmod|resistance resistance|compound|END_ENTITY	A novel approach localizes the association of vitamin_D status with insulin resistance to one region of the 25-hydroxyvitamin_D continuum .
23987236	0	25-hydroxyvitamin_D	12,31	insulin	51,58	25-hydroxyvitamin D	insulin	MESH:C104450	3630	Chemical	Gene	associated|nsubjpass|START_ENTITY associated|nmod|cross-sectionally cross-sectionally|compound|END_ENTITY	Circulating 25-hydroxyvitamin_D is associated with insulin resistance cross-sectionally but not longitudinally in older adults : The Cardiovascular Health Study .
26132208	0	25-hydroxyvitamin_D	22,41	insulin	106,113	25-hydroxyvitamin D	insulin	MESH:C104450	3630	Chemical	Gene	weight_loss|amod|START_ENTITY increase|nmod|weight_loss contribute|nsubj|increase contribute|nmod|improvement improvement|nmod|sensitivity sensitivity|compound|END_ENTITY	The increase in serum 25-hydroxyvitamin_D following weight_loss does not contribute to the improvement in insulin sensitivity , insulin secretion and b-cell function .
15750693	0	25-hydroxyvitamin_D	26,45	parathyroid_hormone	57,76	25-hydroxyvitamin D	parathyroid hormone	MESH:C104450	5741	Chemical	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	Seasonal changes of serum 25-hydroxyvitamin_D and intact parathyroid_hormone levels in a normal Japanese population .
17578859	0	25-hydroxyvitamin_D	30,49	parathyroid_hormone	61,80	25-hydroxyvitamin D	parathyroid hormone	MESH:C104450	5741	Chemical	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	A longitudinal study of serum 25-hydroxyvitamin_D and intact parathyroid_hormone levels indicate the importance of vitamin_D and calcium homeostasis regulation in multiple_sclerosis .
20861214	0	25-hydroxyvitamin_D	29,48	parathyroid_hormone	76,95	25-hydroxyvitamin D	parathyroid hormone	MESH:C104450	5741	Chemical	Gene	START_ENTITY|nmod|suppression suppression|nmod|END_ENTITY	An inflection point of serum 25-hydroxyvitamin_D for maximal suppression of parathyroid_hormone is not evident from multi-site pooled data in children and adolescents .
22617336	0	25-hydroxyvitamin_D	75,94	vitamin_D_receptor	16,34	25-hydroxyvitamin D	vitamin D receptor	MESH:C104450	102130594	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Coronary artery vitamin_D_receptor expression and plasma concentrations of 25-hydroxyvitamin_D : their association with atherosclerosis .
22971535	0	25-hydroxyvitamin_D	10,29	vitamin_D_receptor	55,73	25-hydroxyvitamin D	vitamin D receptor	MESH:C104450	7421	Chemical	Gene	deficiency|amod|START_ENTITY deficiency|nmod|gene gene|compound|END_ENTITY	Status of 25-hydroxyvitamin_D deficiency and effect of vitamin_D_receptor gene polymorphisms on bone_mineral_density in thalassemia patients of North India .
26078251	0	25-hydroxyvitamin_D	66,85	vitamin_D_receptor	33,51	25-hydroxyvitamin D	vitamin D receptor	MESH:C104450	7421	Chemical	Gene	alkaline_phosphatase|amod|START_ENTITY parameters|compound|alkaline_phosphatase Effects|nmod|parameters Effects|nmod|gene gene|compound|END_ENTITY	Effects of Fok-I polymorphism in vitamin_D_receptor gene on serum 25-hydroxyvitamin_D , bone-specific alkaline_phosphatase and calcaneal quantitative ultrasound parameters in young adults .
8939905	0	25-hydroxyvitamin_D3	75,95	CYP24	112,117	25-hydroxyvitamin D3	CYP24	MESH:D002112	25279(Tax:10116)	Chemical	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Transcriptional synergism between vitamin_D-responsive elements in the rat 25-hydroxyvitamin_D3 24-hydroxylase -LRB- CYP24 -RRB- promoter .
12899520	0	25-hydroxyvitamin_D3	42,62	CYP27B1	84,91	25-hydroxyvitamin D3	CYP27B1	MESH:D002112	1594	Chemical	Gene	1,alpha-hydroxylase|amod|START_ENTITY 1,alpha-hydroxylase|appos|END_ENTITY	Gene amplification and splice variants of 25-hydroxyvitamin_D3 1,alpha-hydroxylase -LRB- CYP27B1 -RRB- in glioblastoma multiforme -- a possible role in tumor progression ?
15972816	0	25-hydroxyvitamin_D3	79,99	CYP27B1	44,51	25-hydroxyvitamin D3	CYP27B1	MESH:D002112	13115(Tax:10090)	Chemical	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of the amino_acid residue of CYP27B1 responsible for binding of 25-hydroxyvitamin_D3 whose mutation causes vitamin_D-dependent_rickets_type_1 .
20193763	0	25-hydroxyvitamin_D3	74,94	CYP27B1	115,122	25-hydroxyvitamin D3	CYP27B1	MESH:D002112	13115(Tax:10090)	Chemical	Gene	1alpha-hydroxylase|amod|START_ENTITY mouse|amod|1alpha-hydroxylase mouse|appos|END_ENTITY	Metabolism of substrates incorporated into phospholipid vesicles by mouse 25-hydroxyvitamin_D3 1alpha-hydroxylase -LRB- CYP27B1 -RRB- .
23307792	0	25-hydroxyvitamin_D3	113,133	CYP27B1	155,162	25-hydroxyvitamin D3	CYP27B1	MESH:D002112	1594	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Thyroid hormones decrease plasma 1a,25-dihydroxyvitamin _ D levels through transcriptional repression of the renal 25-hydroxyvitamin_D3 1a-hydroxylase gene -LRB- CYP27B1 -RRB- .
10218975	0	25-hydroxyvitamin_D3	47,67	parathyroid_hormone	95,114	25-hydroxyvitamin D3	parathyroid hormone	MESH:D002112	19226(Tax:10090)	Chemical	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Positive and negative regulations of the renal 25-hydroxyvitamin_D3 1alpha-hydroxylase gene by parathyroid_hormone , calcitonin , and 1alpha ,25 -LRB- OH -RRB- 2D3 in intact animals .
18304585	0	25OHD	20,25	PTH	56,59	25OHD	PTH	null	5741	Chemical	Gene	role|nmod|START_ENTITY role|nmod|regulation regulation|nmod|expression expression|compound|END_ENTITY	Predominant role of 25OHD in the negative regulation of PTH expression : clinical relevance for hypovitaminosis D. Although severe deficiency_of_bioactive_vitamin_D -LRB- 1,25 OH2D -RRB- causes rickets , mild insufficiency of the hormone , known as hypovitaminosis D , is responsible for the occurrence of secondary_hyperparathyroidism and osteoporosis .
20858421	2	25_amino-acid	218,231	SP-B	244,248	25 amino-acid	SP-B	null	6439	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	SP-B -LRB- 1-25 -RRB- , a peptide comprised of the N-terminal 25_amino-acid residues of SP-B , is known to retain much of the biological activity of SP-B .
25497142	0	27-Hydroxycholesterol	0,21	CD14	35,39	27-Hydroxycholesterol	CD14	MESH:C076996	929	Chemical	Gene	up-regulates|amod|START_ENTITY END_ENTITY|nsubj|up-regulates	27-Hydroxycholesterol up-regulates CD14 and predisposes monocytic cells to superproduction of CCL2 in response to lipopolysaccharide .
25598661	0	27-hydroxycholesterol	97,118	Interleukin-1a	63,77	27-hydroxycholesterol	Interleukin-1a	MESH:C076996	3552	Chemical	Gene	Presence|nmod|START_ENTITY END_ENTITY|nmod|Presence	FSL-1 , a Toll-like_Receptor_2 / 6 Agonist , Induces Expression of Interleukin-1a in the Presence of 27-hydroxycholesterol .
23246833	0	27-hydroxycholesterol	0,21	tumor_necrosis_factor-alpha	44,71	27-hydroxycholesterol	tumor necrosis factor-alpha	MESH:C076996	7124	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|nmod|END_ENTITY	27-hydroxycholesterol induces production of tumor_necrosis_factor-alpha from macrophages .
6630356	0	28-amino_acid	75,88	parathyroid_hormone	99,118	28-amino acid	parathyroid hormone	null	5741	Chemical	Gene	antagonist|amod|START_ENTITY antagonist|compound|END_ENTITY	Semi-preparative high-performance liquid chromatographic purification of a 28-amino_acid synthetic parathyroid_hormone antagonist .
26617310	0	2Fe-2S	70,76	Ferredoxin	89,99	2Fe-2S	Ferredoxin	null	39070(Tax:7227)	Chemical	Gene	Complex|amod|START_ENTITY Complex|nmod|END_ENTITY	Magnetostructural Dynamics from Hubbard-U Corrected Spin-Projection : -LSB- 2Fe-2S -RSB- Complex in Ferredoxin .
1317854	0	2Fe-2S	46,52	ferredoxin	54,64	2Fe-2S	ferredoxin	null	1343206(Tax:303)	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Cloning , sequencing , and overexpression of a -LSB- 2Fe-2S -RSB- ferredoxin gene from Escherichia_coli .
18986169	0	2Fe2S	80,85	IscU	75,79	2Fe2S	IscU	null	23479	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	Studies on the mechanism of catalysis of iron-sulfur cluster transfer from IscU -LSB- 2Fe2S -RSB- by HscA/HscB chaperones .
17766440	0	2Fe_2S	30,36	MitoNEET	0,8	2Fe 2S	MitoNEET	null	55847	Chemical	Gene	protein|compound|START_ENTITY protein|nsubj|END_ENTITY	MitoNEET is a uniquely folded 2Fe_2S outer mitochondrial membrane protein stabilized by pioglitazone .
25462230	0	2H-chromen-2-one	26,42	MAO-B	79,84	2H-chromen-2-one	MAO-B	CHEBI:28794	25750(Tax:10116)	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	In silico design of novel 2H-chromen-2-one derivatives as potent and selective MAO-B inhibitors .
18700741	0	2alpha-hydroxyursolic_acid	10,36	TNF-alpha	72,81	2alpha-hydroxyursolic acid	TNF-alpha	MESH:C412810	7124	Chemical	Gene	Effect|nmod|START_ENTITY induced|nsubj|Effect induced|nmod|END_ENTITY	Effect of 2alpha-hydroxyursolic_acid on NF-kappaB activation induced by TNF-alpha in human breast_cancer MCF-7 cells .
26771619	0	3,1-Benzothiazines	0,18	Matriptase-2	76,88	3,1-Benzothiazines	Matriptase-2	null	164656	Chemical	Gene	START_ENTITY|nmod|Inhibitors Inhibitors|nmod|END_ENTITY	3,1-Benzothiazines , 1,4-Benzodioxines and 1,4-Benzoxazines as Inhibitors of Matriptase-2 : Outcome of a Focused Screening Approach .
7829074	0	3,2-trans-enoyl-CoA	20,39	DCI	51,54	3,2-trans-enoyl-CoA	DCI	null	1632	Chemical	Gene	isomerase|amod|START_ENTITY isomerase|appos|END_ENTITY	Human mitochondrial 3,2-trans-enoyl-CoA isomerase -LRB- DCI -RRB- : gene structure and localization to chromosome 16p13 .3 .
18008070	0	3,4,5,6-tetrahydrouridine	52,77	cytidine_deaminase	81,99	3,4,5,6-tetrahydrouridine	cytidine deaminase	null	72269(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Plasma pharmacokinetics and oral bioavailability of 3,4,5,6-tetrahydrouridine , a cytidine_deaminase inhibitor , in mice .
15267236	0	3,4,6-triphenylpyran-2-ones	66,93	cyclooxygenase-2	107,123	3,4,6-triphenylpyran-2-ones	cyclooxygenase-2	null	29527(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Design , synthesis , and structure-activity relationship studies of 3,4,6-triphenylpyran-2-ones as selective cyclooxygenase-2 inhibitors .
23994369	0	3,4-Dihydroxy-5-nitrobenzaldehyde	0,33	xanthine_oxidase	66,82	3,4-Dihydroxy-5-nitrobenzaldehyde	xanthine oxidase	null	22436(Tax:10090)	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	3,4-Dihydroxy-5-nitrobenzaldehyde -LRB- DHNB -RRB- is a potent inhibitor of xanthine_oxidase : a potential therapeutic agent for treatment of hyperuricemia and gout .
8254620	0	3,4-Dihydroxychalcones	0,22	5-lipoxygenase	33,47	3,4-Dihydroxychalcones	5-lipoxygenase	null	240	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	3,4-Dihydroxychalcones as potent 5-lipoxygenase and cyclooxygenase inhibitors .
2642019	0	3,4-LICAMS	80,90	transferrin	65,76	3,4-LICAMS	transferrin	MESH:C030662	7018	Chemical	Gene	evaluation|nmod|START_ENTITY evaluation|nmod|END_ENTITY	Further evaluation of the biphasic kinetics of iron removal from transferrin by 3,4-LICAMS .
26114810	0	3,4-diaminobenzoyl	13,31	factor_Xa	47,56	3,4-diaminobenzoyl	factor Xa	null	2159	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Synthesis of 3,4-diaminobenzoyl derivatives as factor_Xa inhibitors .
12729631	0	3,4-diarylfuranones	28,47	cyclooxygenase-2	99,115	3,4-diarylfuranones	cyclooxygenase-2	null	5743	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Conformationally restricted 3,4-diarylfuranones -LRB- 2,3a,4,5-tetrahydronaphthofuranones -RRB- as selective cyclooxygenase-2 inhibitors .
20398795	0	3,4-dichloroaniline	11,30	ahr2	48,52	3,4-dichloroaniline	ahr2	MESH:C014464	30517(Tax:7955)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of 3,4-dichloroaniline on expression of ahr2 and cyp1a1 in zebrafish adults and embryos .
8618041	0	3,4-didehydroretinol	28,48	CRABPII	84,91	3,4-didehydroretinol	CRABPII	MESH:C024366	1382	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Increased concentrations of 3,4-didehydroretinol and retinoic_acid-binding protein -LRB- CRABPII -RRB- in human squamous_cell_carcinoma and keratoacanthoma but not in basal_cell_carcinoma_of_the_skin .
16644117	0	3,4-methylenedioxymethamphetamine	24,57	BDNF	79,83	3,4-methylenedioxymethamphetamine	BDNF	CHEBI:1391	24225(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|amod|END_ENTITY	Differential effects of 3,4-methylenedioxymethamphetamine -LRB- MDMA , `` ecstasy '' -RRB- on BDNF mRNA expression in rat frontal cortex and hippocampus .
18794647	0	3,4-methylenedioxymethamphetamine	20,53	CYP2D6	62,68	3,4-methylenedioxymethamphetamine	CYP2D6	CHEBI:1391	1565	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|compound|END_ENTITY	The consequences of 3,4-methylenedioxymethamphetamine induced CYP2D6 inhibition in humans .
22197270	0	3,4-methylenedioxymethamphetamine	57,90	prolactin	25,34	3,4-methylenedioxymethamphetamine	prolactin	D018817	707052(Tax:9544)	Chemical	Gene	elicited|advcl|START_ENTITY secretion|acl|elicited secretion|compound|END_ENTITY	The neuropharmacology of prolactin secretion elicited by 3,4-methylenedioxymethamphetamine -LRB- `` ecstasy '' -RRB- : a concurrent microdialysis and plasma analysis study .
2898523	0	3,4-methylenedioxymethamphetamine	102,135	prolactin	19,28	3,4-methylenedioxymethamphetamine	prolactin	CHEBI:1391	24683(Tax:10116)	Chemical	Gene	administration|nmod|START_ENTITY END_ENTITY|nmod|administration	Elevation of serum prolactin and corticosterone concentrations in the rat after the administration of 3,4-methylenedioxymethamphetamine .
21144881	0	3,4-methylenedioxyphenol	24,48	tyrosinase	55,65	3,4-methylenedioxyphenol	tyrosinase	MESH:C025583	22173(Tax:10090)	Chemical	Gene	Interaction|dep|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of sesamol -LRB- 3,4-methylenedioxyphenol -RRB- with tyrosinase and its effect on melanin synthesis .
25101911	0	3,5-Diaryl-2-aminopyridine	35,61	ALK2	62,66	3,5-Diaryl-2-aminopyridine	ALK2	null	90	Chemical	Gene	Inhibitors|amod|START_ENTITY Inhibitors|compound|END_ENTITY	Structure-Activity Relationship of 3,5-Diaryl-2-aminopyridine ALK2 Inhibitors Reveals Unaltered Binding Affinity for Fibrodysplasia Ossificans Progressiva Causing Mutants .
10803583	0	3,5-diiodo-L-thyronine	0,22	glucose-6-phosphate_dehydrogenase	33,66	3,5-diiodo-L-thyronine	glucose-6-phosphate dehydrogenase	MESH:C030103|MESH:C030102	24377(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	3,5-diiodo-L-thyronine regulates glucose-6-phosphate_dehydrogenase activity in the rat .
2643195	4	3-0-methylglucose	509,526	glucose	569,576	3-0-methylglucose	insulin	null	3630	Chemical	Gene	transport|amod|START_ENTITY effects|nmod|transport effects|nmod|END_ENTITY	In isolated fat cells after surgery there was a significant overall reduction of 35 % to 50 % of the effects of insulin on 3-0-methylglucose transport and lipogenesis at 1 mumol/L of glucose -LRB- where hexose transport is rate-limiting for insulin action -RRB- .
26728896	0	3-AWA	94,99	c-FLIP	63,69	3-AWA	c-FLIP	null	12633(Tax:10090)	Chemical	Gene	mechanism|nmod|START_ENTITY mechanism|amod|END_ENTITY	Dual modulation of Ras-Mnk and PI3K-AKT-mTOR pathways : A Novel c-FLIP inhibitory mechanism of 3-AWA mediated translational attenuation through dephosphorylation of eIF4E .
10514295	0	3-Alkyl-6-chloro-2-pyrones	0,26	pancreatic_cholesterol_esterase	52,83	3-Alkyl-6-chloro-2-pyrones	pancreatic cholesterol esterase	null	1056	Chemical	Gene	START_ENTITY|dep|inhibitors inhibitors|nmod|END_ENTITY	3-Alkyl-6-chloro-2-pyrones : selective inhibitors of pancreatic_cholesterol_esterase .
12895500	0	3-Amino_thioacridone	0,20	cyclin-dependent_kinase_4	34,59	3-Amino thioacridone	cyclin-dependent kinase 4	MESH:C479067	1019	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	3-Amino_thioacridone , a selective cyclin-dependent_kinase_4 inhibitor , attenuates kainic_acid-induced apoptosis in neurons .
24568202	0	3-Aminobenzamide	0,16	PARP	20,24	3-Aminobenzamide	PARP	MESH:C025160	11545(Tax:10090)	Chemical	Gene	START_ENTITY|dep|enhances enhances|nsubj|inhibitor inhibitor|compound|END_ENTITY	3-Aminobenzamide -- a PARP inhibitor enhances the sensitivity of peripheral blood micronucleus and comet assays in mice .
6295658	0	3-Aminobenzamide	0,16	poly_ADP-ribose_polymerase	34,60	3-Aminobenzamide	poly ADP-ribose polymerase	MESH:C025160	142	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	3-Aminobenzamide , an inhibitor of poly_ADP-ribose_polymerase , decreases the frequency of alkaline labile lesions and increases growth in human fibroblasts exposed to 3-methyl_4-nitroquinoline_1-oxide .
16678414	0	3-Benzimidazol-2-yl-1H-indazoles	0,32	c-ABL	43,48	3-Benzimidazol-2-yl-1H-indazoles	c-ABL	null	25	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	3-Benzimidazol-2-yl-1H-indazoles as potent c-ABL inhibitors .
25053988	0	3-BrPA	25,31	Hexokinase_II	0,13	3-BrPA	Hexokinase II	null	3099	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Hexokinase_II inhibitor , 3-BrPA induced autophagy by stimulating ROS formation in human breast_cancer cells .
24492287	0	3-Bromopyruvate	0,15	Mcl-1	75,80	3-Bromopyruvate	Mcl-1	MESH:C017092	4170	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|downregulating downregulating|dobj|END_ENTITY	3-Bromopyruvate induces apoptosis in breast_cancer cells by downregulating Mcl-1 through the PI3K/Akt signaling pathway .
24738957	0	3-Bromopyruvic_acid	0,19	hexokinase_II	23,36	3-Bromopyruvic acid	hexokinase II	MESH:C017092	15277(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	3-Bromopyruvic_acid , a hexokinase_II inhibitor , is an effective antitumor agent on the hepatoma cells : in vitro and in vivo findings .
3457563	0	3-Deazaneplanocin	0,17	S-adenosylhomocysteine_hydrolase	49,81	3-Deazaneplanocin	S-adenosylhomocysteine hydrolase	MESH:C048460	191	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	3-Deazaneplanocin : a new and potent inhibitor of S-adenosylhomocysteine_hydrolase and its effects on human promyelocytic_leukemia cell line HL-60 .
24852755	0	3-Deazaneplanocin_A	0,19	EZH2	75,79	3-Deazaneplanocin A	EZH2	MESH:C048460	14056(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	3-Deazaneplanocin_A -LRB- DZNep -RRB- , an inhibitor of the histone methyltransferase EZH2 , induces apoptosis and reduces cell migration in chondrosarcoma cells .
21628889	0	3-Deoxysappanchalcone	0,21	matrix_metalloproteinase-9	63,89	3-Deoxysappanchalcone	matrix metalloproteinase-9	MESH:C542297	4318	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	3-Deoxysappanchalcone inhibits tumor_necrosis_factor-a-induced matrix_metalloproteinase-9 expression in human keratinocytes through activated protein-1 inhibition and nuclear factor-kappa B DNA binding activity .
22326527	0	3-Hydroxy-3-methylglutaryl_coenzyme_A	0,37	HMG1	51,55	3-Hydroxy-3-methylglutaryl coenzyme A	HMG1	MESH:C008047	10354	Chemical	Gene	reductase|amod|START_ENTITY reductase|appos|END_ENTITY	3-Hydroxy-3-methylglutaryl_coenzyme_A reductase 1 -LRB- HMG1 -RRB- is highly associated with the cell division during the early stage of fruit development which determines the final fruit size in Litchi chinensis .
18003900	0	3-Hydroxyanthranilic_acid	0,25	PDK1	35,39	3-Hydroxyanthranilic acid	PDK1	MESH:D015095	5163	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|compound|END_ENTITY	3-Hydroxyanthranilic_acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis .
16246346	0	3-Hydroxyanthranilic_acid	0,25	monocyte_chemoattractant_protein-1	69,103	3-Hydroxyanthranilic acid	monocyte chemoattractant protein-1	MESH:D015095	6347	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|amod|END_ENTITY	3-Hydroxyanthranilic_acid , one of L-tryptophan metabolites , inhibits monocyte_chemoattractant_protein-1 secretion and vascular_cell_adhesion_molecule-1 expression via heme_oxygenase-1 induction in human umbilical vein endothelial cells .
17356845	0	3-Hydroxyglutaric_acid	0,22	NaDC3	89,94	3-Hydroxyglutaric acid	NaDC3	MESH:C108959	114644(Tax:10090)	Chemical	Gene	transported|nsubjpass|START_ENTITY transported|nmod|END_ENTITY	3-Hydroxyglutaric_acid is transported via the sodium-dependent dicarboxylate transporter NaDC3 .
25706283	0	3-Iodothyronamine	28,45	Trace_Amine-Associated_Receptor_5	59,92	3-Iodothyronamine	Trace Amine-Associated Receptor 5	MESH:C487948	9038	Chemical	Gene	Action|nmod|START_ENTITY Action|nmod|END_ENTITY	Inverse Agonistic Action of 3-Iodothyronamine at the Human Trace_Amine-Associated_Receptor_5 .
6635324	0	3-MC	10,14	G-6-PD	46,52	3-MC	G-6-PD	MESH:D008748	24377(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of 3-MC on cholesterolemia and hepatic G-6-PD .
26322521	0	3-Mercaptopicolinic_Acid	87,111	Phosphoenolpyruvate_Carboxykinase	50,83	3-Mercaptopicolinic Acid	Phosphoenolpyruvate Carboxykinase	MESH:C008363	5106	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Inhibition and Allosteric Regulation of Monomeric Phosphoenolpyruvate_Carboxykinase by 3-Mercaptopicolinic_Acid .
24658119	0	3-Methylcholanthrene	0,20	AhR	25,28	3-Methylcholanthrene	AhR	MESH:D008748	196	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	3-Methylcholanthrene , an AhR agonist , caused cell-cycle arrest by histone deacetylation through a RhoA-dependent recruitment of HDAC1 and pRb2 to E2F1 complex .
17276403	0	3-Methylcholanthrene	0,20	CYP1A1	57,63	3-Methylcholanthrene	CYP1A1	MESH:D008748	24296(Tax:10116)	Chemical	Gene	elicits|amod|START_ENTITY DNA|nsubj|elicits DNA|nmod|region region|compound|END_ENTITY	3-Methylcholanthrene elicits DNA adduct formation in the CYP1A1 promoter region and attenuates reporter gene expression in rat H4IIE cells .
7493548	0	3-Methylcholanthrene	0,20	CYP1A1	45,51	3-Methylcholanthrene	CYP1A1	MESH:D008748	24296(Tax:10116)	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|END_ENTITY	3-Methylcholanthrene and pyridine effects on CYP1A1 and CYP1A2 expression in rat renal tissue .
16489053	0	3-Methylcholanthrene	0,20	aryl_hydrocarbon_receptor	31,56	3-Methylcholanthrene	aryl hydrocarbon receptor	MESH:D008748	196	Chemical	Gene	agonists|amod|START_ENTITY agonists|compound|END_ENTITY	3-Methylcholanthrene and other aryl_hydrocarbon_receptor agonists directly activate estrogen_receptor_alpha .
8292607	0	3-Methyleneoctanoyl-CoA	0,23	medium_chain_acyl-CoA_dehydrogenase	97,132	3-Methyleneoctanoyl-CoA	medium chain acyl-CoA dehydrogenase	MESH:C085494	397104(Tax:9823)	Chemical	Gene	START_ENTITY|dep|inhibitors inhibitors|nmod|END_ENTITY	3-Methyleneoctanoyl-CoA and 3-methyl-trans-2-octenoyl-CoA : two new mechanism-based inhibitors of medium_chain_acyl-CoA_dehydrogenase from pig kidney .
14550925	0	3-Nitropropionic_acid	0,21	frataxin	32,40	3-Nitropropionic acid	frataxin	MESH:C015392	2395	Chemical	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	3-Nitropropionic_acid increases frataxin expression in human lymphoblasts and in transgenic rat PC12 cells .
17332142	0	3-O-methylfluorescein	14,35	CYP2C19	78,85	3-O-methylfluorescein	CYP2C19	null	1557	Chemical	Gene	START_ENTITY|nmod|substrate substrate|nmod|END_ENTITY	Evaluation of 3-O-methylfluorescein as a selective fluorometric substrate for CYP2C19 in human liver microsomes .
6341390	0	3-O-methylglucose	64,81	Insulin	0,7	3-O-methylglucose	Insulin	MESH:D019325	3630	Chemical	Gene	transport|amod|START_ENTITY reverses|nmod|transport reverses|nsubj|treatment treatment|compound|END_ENTITY	Insulin treatment reverses the postreceptor defect in adipocyte 3-O-methylglucose transport in type_II_diabetes_mellitus .
2158304	15	3-O-methylglucose	2065,2082	insulin	2046,2053	3-O-methylglucose	insulin	MESH:D019325	3630	Chemical	Gene	effects|nmod|START_ENTITY effects|compound|END_ENTITY	We also found that the effect of insulin on lipogenesis was blocked by mannose , glucosamine and inositol_monophosphate , whereas the insulin effects on 3-O-methylglucose , cyclic_AMP and lipolysis were unaffected .
2258133	0	3-O-methylglucose	70,87	insulin	13,20	3-O-methylglucose	insulin	MESH:D019325	105613195	Chemical	Gene	transport|amod|START_ENTITY Mechanism|dep|transport Mechanism|nmod|resistance resistance|compound|END_ENTITY	Mechanism of insulin resistance in the post receptor events in sheep : 3-O-methylglucose transport in ovine adipocytes .
6343370	0	3-O-methylglucose	38,55	insulin	10,17	3-O-methylglucose	insulin	MESH:D019325	3630	Chemical	Gene	muscles|amod|START_ENTITY transport|nmod|muscles Action|nmod|transport Action|nmod|END_ENTITY	Action of insulin on the transport of 3-O-methylglucose in frog sartorius muscles .
8968865	0	3-O-methylglucose	41,58	somatostatin	15,27	3-O-methylglucose	somatostatin	MESH:D019325	403993(Tax:9615)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Stimulation Stimulation|nmod|END_ENTITY	Stimulation of somatostatin secretion by 3-O-methylglucose in the perfused dog pancreas .
20053680	0	3-OH	59,63	p110beta	22,30	3-OH	p110beta	null	74769(Tax:10090)	Chemical	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	Essential role of the p110beta subunit of phosphoinositide 3-OH kinase in male fertility .
21514825	0	3-Oxo-2-piperazinyl_acetamides	0,30	bradykinin_B1_receptor	41,63	3-Oxo-2-piperazinyl acetamides	bradykinin B1 receptor	null	100009198(Tax:9986)	Chemical	Gene	START_ENTITY|nmod|antagonists antagonists|amod|END_ENTITY	3-Oxo-2-piperazinyl_acetamides as potent bradykinin_B1_receptor antagonists for the treatment of pain and inflammation .
20634487	0	3-PUFAs	81,88	PPAR_gamma	21,31	3-PUFAs	PPAR gamma	null	19016(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY mediates|dobj|effect mediates|nsubj|END_ENTITY	Short communication : PPAR_gamma mediates a direct antiangiogenic effect of omega 3-PUFAs in proliferative_retinopathy .
3995005	0	3-Phenylpropenes	0,16	dopamine_beta-hydroxylase	50,75	3-Phenylpropenes	dopamine beta-hydroxylase	null	1621	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	3-Phenylpropenes as mechanism-based inhibitors of dopamine_beta-hydroxylase : evidence for a radical mechanism .
25258678	0	3-Substituted_Biquinolinium	0,27	VirF	80,84	3-Substituted Biquinolinium	VirF	null	13917072	Chemical	Gene	Inhibitors|amod|START_ENTITY Inhibitors|nmod|END_ENTITY	3-Substituted_Biquinolinium Inhibitors of AraC Family Transcriptional Activator VirF from S. _ flexneri Obtained Through In Situ Chemical Ionization of 3,4-Disubstituted _ Dihydroquinolines .
6686615	0	3-acetylpyridine	116,132	CA3	68,71	3-acetylpyridine	CA3	MESH:C010835	12350(Tax:10090)	Chemical	Gene	administration|nmod|START_ENTITY END_ENTITY|nmod|administration	Learning_deficits on avoidance task and hippocampal lesions in area CA3 following intraperitoneal administration of 3-acetylpyridine .
23581551	0	3-alkylindole	72,85	myeloperoxidase	129,144	3-alkylindole	myeloperoxidase	null	4353	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|inhibitors inhibitors|compound|END_ENTITY	Design , synthesis , and structure-activity relationship studies of novel 3-alkylindole derivatives as selective and highly potent myeloperoxidase inhibitors .
18215519	0	3-amino-1-alkyl-cyclopentane_carboxamide	26,66	CCR2	67,71	3-amino-1-alkyl-cyclopentane carboxamide	CCR2	null	729230	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|compound|END_ENTITY	Conformational studies of 3-amino-1-alkyl-cyclopentane_carboxamide CCR2 antagonists leading to new spirocyclic antagonists .
11829410	0	3-amino-triazole	37,53	catalase	14,22	3-amino-triazole	catalase	null	12359(Tax:10090)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Inhibition of catalase activity with 3-amino-triazole enhances the cytotoxicity of the Alzheimer 's amyloid-beta peptide .
15670817	0	3-aminobenzamide	37,53	PARP	71,75	3-aminobenzamide	PARP	MESH:C025160	1302	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Differentiative pathway activated by 3-aminobenzamide , an inhibitor of PARP , in human osteosarcoma MG-63 cells .
16085349	0	3-aminobenzamide	10,26	PARP	28,32	3-aminobenzamide	PARP	MESH:C025160	25591(Tax:10116)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Effect of 3-aminobenzamide , PARP inhibitor , on matrix_metalloproteinase-9 level in plasma and brain of ischemic_stroke model .
19699512	0	3-aminobenzamide	83,99	PARP	67,71	3-aminobenzamide	PARP	MESH:C025160	142	Chemical	Gene	sensitizes|xcomp|START_ENTITY sensitizes|nmod|inhibitor inhibitor|compound|END_ENTITY	BMS-536924 sensitizes human epithelial_ovarian_cancer cells to the PARP inhibitor , 3-aminobenzamide .
12379459	0	3-aminobenzamide	93,109	parp	128,132	3-aminobenzamide	parp	MESH:C025160	11545(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitior inhibitior|nmod|enzyme enzyme|compound|END_ENTITY	Differential gene expression in gamma-irradiated BALB/3T3 fibroblasts under the influence of 3-aminobenzamide , an inhibitior of parp enzyme .
9144832	0	3-aminobenzamide	14,30	poly-ADP-ribose_polymerase	48,74	3-aminobenzamide	poly-ADP-ribose polymerase	MESH:C025160	25591(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|inhibitor inhibitor|nmod|END_ENTITY	The effect of 3-aminobenzamide , an inhibitor of poly-ADP-ribose_polymerase , on ischemia/reperfusion damage in rat retina .
23359111	0	3-aminopropanamide	58,76	epidermal_growth_factor_receptor	108,140	3-aminopropanamide	epidermal growth factor receptor	null	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Molecular mechanisms underlying the antitumor activity of 3-aminopropanamide irreversible inhibitors of the epidermal_growth_factor_receptor in non-small_cell_lung_cancer .
20060294	0	3-aminopyrazole	6,21	MK-2	36,40	3-aminopyrazole	MK-2	MESH:C436945	9261	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Novel 3-aminopyrazole inhibitors of MK-2 discovered by scaffold hopping strategy .
23585245	0	3-aryl-4-pyrrolyl-maleimides	37,65	glycogen_synthase_kinase-3b	69,96	3-aryl-4-pyrrolyl-maleimides	glycogen synthase kinase-3b	null	2932	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Design , synthesis , and evaluation of 3-aryl-4-pyrrolyl-maleimides as glycogen_synthase_kinase-3b inhibitors .
15896964	0	3-aryl_piperidine	28,45	dopamine_D4_receptor	80,100	3-aryl piperidine	dopamine D4 receptor	null	1815	Chemical	Gene	analogs|amod|START_ENTITY analogs|nmod|END_ENTITY	Synthesis and evaluation of 3-aryl_piperidine analogs as potent and efficacious dopamine_D4_receptor agonists .
10517292	0	3-azidiamantane	14,29	cytochrome_P450	56,71	3-azidiamantane	cytochrome P450	MESH:C121999	25251(Tax:10116)	Chemical	Gene	Evaluation|nmod|START_ENTITY Evaluation|nmod|END_ENTITY	Evaluation of 3-azidiamantane as photoaffinity probe of cytochrome_P450 .
25969134	0	3-azido_Withaferin_A	95,115	Par-4	0,5	3-azido Withaferin A	Par-4	MESH:C577558	347745	Chemical	Gene	modulation|nmod|START_ENTITY modulation|amod|END_ENTITY	Par-4 dependent modulation of cellular b-catenin by medicinal plant natural product derivative 3-azido_Withaferin_A .
25969134	0	3-azido_Withaferin_A	95,115	b-catenin	39,48	3-azido Withaferin A	b-catenin	MESH:C577558	1499	Chemical	Gene	modulation|nmod|START_ENTITY modulation|nmod|END_ENTITY	Par-4 dependent modulation of cellular b-catenin by medicinal plant natural product derivative 3-azido_Withaferin_A .
9717516	0	3-benzoylpyridine	57,74	CYP3A	25,30	3-benzoylpyridine	CYP3A	MESH:C040916	170509(Tax:10116)	Chemical	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	Comparative induction of CYP3A and CYP2B in rat liver by 3-benzoylpyridine and metyrapone .
23698055	0	3-benzylcoumarins	12,29	MEK1	44,48	3-benzylcoumarins	MEK1	null	5604	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Substituted 3-benzylcoumarins as allosteric MEK1 inhibitors : design , synthesis and biological evaluation as antiviral agents .
15492487	0	3-beta-hydroxysteroid	27,48	TRPV1	86,91	3-beta-hydroxysteroid	TRPV1	CHEBI:36836	83810(Tax:10116)	Chemical	Gene	mRNA|amod|START_ENTITY mRNA|compound|END_ENTITY	Differential regulation of 3-beta-hydroxysteroid dehydrogenase and vanilloid receptor TRPV1 mRNA in sensory neurons by capsaicin and NGF .
22322891	0	3-bromopyruvate	43,58	hexokinase	119,129	3-bromopyruvate	hexokinase	MESH:C017092	851167(Tax:4932)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|role role|nmod|END_ENTITY	Effect of the antitumoral alkylating agent 3-bromopyruvate on mitochondrial respiration : role of mitochondrially bound hexokinase .
19285479	0	3-bromopyruvate	78,93	hexokinase_II	32,45	3-bromopyruvate	hexokinase II	MESH:C017092	3099	Chemical	Gene	induced|advcl|START_ENTITY induced|nsubj|Role Role|nmod|END_ENTITY	Role of mitochondria-associated hexokinase_II in cancer cell death induced by 3-bromopyruvate .
20298537	0	3-carboxamide-coumarin	19,41	factor_XII	67,77	3-carboxamide-coumarin	factor XII	null	58992(Tax:10090)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|nmod|END_ENTITY	COU254 , a specific 3-carboxamide-coumarin inhibitor of coagulation factor_XII , does not protect mice from acute ischemic_stroke .
17880055	0	3-carboxamido-5-phenacylaminopyrazole	44,81	bradykinin_B1_receptor	82,104	3-carboxamido-5-phenacylaminopyrazole	bradykinin B1 receptor	null	623	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|amod|END_ENTITY	Preparation and optimization of a series of 3-carboxamido-5-phenacylaminopyrazole bradykinin_B1_receptor antagonists .
23602524	0	3-cyanopyridine	65,80	EGFR	128,132	3-cyanopyridine	EGFR	MESH:C020729	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Design , synthesis and biological evaluation of novel pyrimidine , 3-cyanopyridine and m-amino-N-phenylbenzamide based monocyclic EGFR tyrosine kinase inhibitors .
19041240	0	3-cyanoquinoline	32,48	insulin-like_growth_factor_receptor	63,98	3-cyanoquinoline	insulin-like growth factor receptor	null	3480	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Lead identification to generate 3-cyanoquinoline inhibitors of insulin-like_growth_factor_receptor -LRB- IGF-1R -RRB- for potential use in cancer treatment .
10383397	0	3-deazaadenosine	0,16	S-adenosylhomocysteine_hydrolase	20,52	3-deazaadenosine	S-adenosylhomocysteine hydrolase	MESH:C018258	269378(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	3-deazaadenosine , a S-adenosylhomocysteine_hydrolase inhibitor , has dual effects on NF-kappaB regulation .
22925699	0	3-deazaneplanocin_A	24,43	EZH2	91,95	3-deazaneplanocin A	EZH2	MESH:C048460	2146	Chemical	Gene	therapy|nmod|START_ENTITY therapy|appos|inhibitor inhibitor|nmod|END_ENTITY	Epigenetic therapy with 3-deazaneplanocin_A , an inhibitor of the histone methyltransferase EZH2 , inhibits growth of non-small_cell_lung_cancer cells .
24226421	0	3-deazaneplanocin_A	98,117	Tumor_necrosis_factor-a	0,23	3-deazaneplanocin A	Tumor necrosis factor-a	MESH:C048460	7124	Chemical	Gene	induction|advcl|START_ENTITY induction|nsubj|END_ENTITY	Tumor_necrosis_factor-a and apoptosis induction in melanoma cells through histone modification by 3-deazaneplanocin_A .
19052366	0	3-dehydroquinate	88,104	Xoo1243	115,122	3-dehydroquinate	Xoo1243	MESH:C474477	3857689(Tax:342109)	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	Cloning , expression , crystallization and preliminary X-ray crystallographic analysis of 3-dehydroquinate synthase , Xoo1243 , from Xanthomonas_oryzae pv .
25283506	0	3-epi-betulinic_acid	18,38	TGR5	75,79	3-epi-betulinic acid	TGR5	null	151306	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Highly lipophilic 3-epi-betulinic_acid derivatives as potent and selective TGR5 agonists with improved cellular efficacy .
24262133	0	3-fatty_acids	63,76	GPR120	0,6	3-fatty acids	GPR120	null	107221(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY mediates|dobj|effects mediates|nsubj|END_ENTITY	GPR120 on Kupffer cells mediates hepatoprotective effects of 3-fatty_acids .
1282509	0	3-fucosyl-N-acetyl-lactosamine	39,69	CD15	71,75	3-fucosyl-N-acetyl-lactosamine	CD15	null	2526	Chemical	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the carbohydrate epitope 3-fucosyl-N-acetyl-lactosamine -LRB- CD15 -RRB- in the vertebrate cerebellar cortex .
1694660	0	3-fucosyl-N-acetyl-lactosamine	48,78	CR3	127,130	3-fucosyl-N-acetyl-lactosamine	CR3	null	6998	Chemical	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the CD15 differentiation antigen -LRB- 3-fucosyl-N-acetyl-lactosamine , LeX -RRB- on putative neutrophil adhesion molecules CR3 and NCA-160 .
22240315	0	3-hydroxy-3-methylglutaryl-Coenzyme_A	85,122	HMGR	134,138	3-hydroxy-3-methylglutaryl-Coenzyme A	HMGR	MESH:C008047	3159	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular cloning , tissue expression and protein structure prediction of the porcine 3-hydroxy-3-methylglutaryl-Coenzyme_A reductase -LRB- HMGR -RRB- gene .
20540816	0	3-hydroxy-3-methylglutaryl-coenzyme_A	40,77	HMGCR	95,100	3-hydroxy-3-methylglutaryl-coenzyme A	HMGCR	MESH:C008047	3156	Chemical	Gene	reductase|amod|START_ENTITY gene|amod|reductase gene|appos|END_ENTITY	A single nucleotide polymorphism in the 3-hydroxy-3-methylglutaryl-coenzyme_A reductase gene -LRB- HMGCR -RRB- influences the serum triacylglycerol relationship with dietary fat and fibre in the European Prospective Investigation into Cancer and Nutrition in Norfolk -LRB- EPIC-Norfolk -RRB- study .
23572922	0	3-hydroxy-3-methylglutaryl-coenzyme_A	44,81	hmgr1	95,100	3-hydroxy-3-methylglutaryl-coenzyme A	hmgr1	MESH:C008047	843982(Tax:3702)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular cloning and characterization of a 3-hydroxy-3-methylglutaryl-coenzyme_A reductase 1 -LRB- hmgr1 -RRB- gene from rubber tree -LRB- Hevea_brasiliensis Muell .
12426205	0	3-hydroxy-3-methylglutaryl_coenzyme_A	0,37	CD40	74,78	3-hydroxy-3-methylglutaryl coenzyme A	CD40	MESH:C008047	958	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|expression expression|compound|END_ENTITY	3-hydroxy-3-methylglutaryl_coenzyme_A reductase-independent inhibition of CD40 expression by atorvastatin in human endothelial cells .
18799749	2	3-hydroxy-acyl-CoA	331,349	PHS1	363,367	3-hydroxy-acyl-CoA	phs1	CHEBI:65260	832437(Tax:3702)	Chemical	Gene	dehydratase|amod|START_ENTITY dehydratase|appos|END_ENTITY	Two Arabidopsis genes are putative homologues of the recently identified yeast 3-hydroxy-acyl-CoA dehydratase -LRB- PHS1 -RRB- , the third enzyme of the elongase complex .
11711305	0	3-hydroxy-anthranilic_acid	34,60	3-HAO	74,79	3-hydroxy-anthranilic acid	3-HAO	MESH:D015095	56823(Tax:10116)	Chemical	Gene	dioxygenase|amod|START_ENTITY dioxygenase|appos|END_ENTITY	QSAR study on inhibition of brain 3-hydroxy-anthranilic_acid dioxygenase -LRB- 3-HAO -RRB- : a molecular connectivity approach .
10076877	0	3-hydroxyacyl-CoA	13,30	LCHAD	46,51	3-hydroxyacyl-CoA	LCHAD	CHEBI:65260	3030	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	Long-chain L 3-hydroxyacyl-CoA dehydrogenase -LRB- LCHAD -RRB- deficiency does not appear to be the primary cause of lipid myopathy in patients with Bannayan-Riley-Ruvalcaba_syndrome -LRB- BRRS -RRB- .
18408953	0	3-hydroxyacyl-coenzyme_A	55,79	LCHAD	95,100	3-hydroxyacyl-coenzyme A	LCHAD	null	3030	Chemical	Gene	deficiency|amod|START_ENTITY deficiency|appos|END_ENTITY	Acute fatty liver of pregnancy and neonatal long-chain 3-hydroxyacyl-coenzyme_A dehydrogenase -LRB- LCHAD -RRB- deficiency .
20599874	0	3-hydroxyanthranilic_acid	0,25	monocyte_chemoattractant_protein-1	59,93	3-hydroxyanthranilic acid	monocyte chemoattractant protein-1	MESH:D015095	6347	Chemical	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	3-hydroxyanthranilic_acid is independently associated with monocyte_chemoattractant_protein-1 -LRB- CCL2 -RRB- and macrophage_inflammatory_protein-1beta -LRB- CCL4 -RRB- in patients with chronic_kidney_disease .
9659387	0	3-hydroxyanthranilic_acid	10,35	tyrosinase	48,58	3-hydroxyanthranilic acid	tyrosinase	MESH:D015095	7299	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of 3-hydroxyanthranilic_acid on mushroom tyrosinase activity .
17178767	0	3-hydroxypilocarpine	62,82	CYP2A6	15,21	3-hydroxypilocarpine	CYP2A6	MESH:C520141	1548	Chemical	Gene	Involvement|amod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of CYP2A6 in the formation of a novel metabolite , 3-hydroxypilocarpine , from pilocarpine in human liver microsomes .
19879375	0	3-keto	51,57	Erg27p	69,75	3-keto	Erg27p	null	850790(Tax:4932)	Chemical	Gene	reductase|amod|START_ENTITY reductase|appos|END_ENTITY	Interactions of oxidosqualene cyclase -LRB- Erg7p -RRB- with 3-keto reductase -LRB- Erg27p -RRB- and other enzymes of sterol biosynthesis in yeast .
24287293	0	3-ketoacylCoA	77,90	thiolase_B	91,101	3-ketoacylCoA	thiolase B	CHEBI:57347	235674(Tax:10090)	Chemical	Gene	mice|amod|START_ENTITY mice|compound|END_ENTITY	Disturbances in cholesterol , bile_acid and glucose metabolism in peroxisomal 3-ketoacylCoA thiolase_B deficient mice fed diets containing high or low fat contents .
19619160	0	3-ketoacyl_CoA	16,30	KCS20	47,52	3-ketoacyl CoA	KCS20	CHEBI:57347	834398(Tax:3702)	Chemical	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Two Arabidopsis 3-ketoacyl_CoA synthase genes , KCS20 and KCS2/DAISY , are functionally redundant in cuticular wax and root suberin biosynthesis , but differentially controlled by osmotic stress .
2221921	0	3-mercaptopicolinic_acid	105,129	phosphoenolpyruvate_carboxykinase	14,47	3-mercaptopicolinic acid	phosphoenolpyruvate carboxykinase	MESH:C008363	5105	Chemical	Gene	epimastigotes|advcl|START_ENTITY epimastigotes|nsubj|Inhibition Inhibition|nmod|cruzi cruzi|amod|END_ENTITY	Inhibition of phosphoenolpyruvate_carboxykinase from Trypanosoma -LRB- Schizotrypanum -RRB- cruzi epimastigotes by 3-mercaptopicolinic_acid : in vitro and in vivo studies .
9153644	0	3-mercaptopropionic_acid	50,74	glutamate_decarboxylase	14,37	3-mercaptopropionic acid	glutamate decarboxylase	MESH:D015097	24957(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Inhibition of glutamate_decarboxylase activity by 3-mercaptopropionic_acid has different time course in the immature and adult rat brains .
17207504	0	3-methyladenine	132,147	Aag	174,177	3-methyladenine	Aag	MESH:C025946	268395(Tax:10090)	Chemical	Gene	mice|amod|START_ENTITY mice|compound|END_ENTITY	The effect of dietary folic_acid deficiency on the cytotoxic and mutagenic responses to methyl_methanesulfonate in wild-type and in 3-methyladenine DNA glycosylase-deficient Aag null mice .
7941752	0	3-methyladenine	10,25	MAG1	4,8	3-methyladenine	MAG1	MESH:C025946	856885(Tax:4932)	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	The MAG1 * 3-methyladenine DNA glycosylase gene is closely linked to the SPT15 TATA-binding TFIID gene on chromosome V-R in Saccharomyces_cerevisiae .
11096091	1	3-methylcholanthrene	137,157	AhR	36,39	3-methylcholanthrene	AhR	MESH:D008748	11622(Tax:10090)	Chemical	Gene	gene|nmod|START_ENTITY END_ENTITY|dep|gene	AhR nuclear translocator - and p53-mediated induction of the murine multidrug resistance mdr1 gene by 3-methylcholanthrene and benzo -LRB- a -RRB- pyrene in hepatoma cells .
18022818	1	3-methylcholanthrene	214,234	AhR	272,275	3-methylcholanthrene	p27	MESH:D008748	10671	Chemical	Gene	START_ENTITY|appos|aryl-hydrocarbon_receptor aryl-hydrocarbon_receptor|appos|END_ENTITY	We previously reported that 3-methylcholanthrene -LRB- 3MC -RRB- , an aryl-hydrocarbon_receptor -LRB- AhR -RRB- agonist , inhibits the proliferation of human umbilical vascular endothelial cells -LRB- HUVECs ; Juan et al. , 2006 , Eur J Pharmacol 530 : 1-8 -RRB- .
12237110	0	3-methylcholanthrene	36,56	CYP1A1	16,22	3-methylcholanthrene	CYP1A1	MESH:D008748	1543	Chemical	Gene	increases|advcl|START_ENTITY increases|dobj|induction induction|compound|END_ENTITY	Serum increases CYP1A1 induction by 3-methylcholanthrene .
12941938	0	3-methylcholanthrene	18,38	CYP1A1	52,58	3-methylcholanthrene	CYP1A1	MESH:D008748	1543	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Oltipraz inhibits 3-methylcholanthrene induction of CYP1A1 by CCAAT/enhancer-binding protein activation .
16393856	0	3-methylcholanthrene	99,119	CYP1A1	133,139	3-methylcholanthrene	CYP1A1	MESH:D008748	1543	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	CCAAT/enhancer binding protein activation by PD98059 contributes to the inhibition of AhR-mediated 3-methylcholanthrene induction of CYP1A1 .
20051482	0	3-methylcholanthrene	70,90	CYP1A1	149,155	3-methylcholanthrene	CYP1A1	MESH:D008748	1543	Chemical	Gene	cells|nmod|START_ENTITY cytochrome_P4501A1|nmod|cells induction|nmod|cytochrome_P4501A1 induction|dep|evidence evidence|nmod|activation activation|nmod|promoter promoter|compound|END_ENTITY	Persistent induction of cytochrome_P4501A1 in human hepatoma cells by 3-methylcholanthrene : evidence for sustained transcriptional activation of the CYP1A1 promoter .
20654333	0	3-methylcholanthrene	41,61	CYP1A1	21,27	3-methylcholanthrene	CYP1A1	MESH:D008748	1543	Chemical	Gene	induction|nmod|START_ENTITY induction|nsubj|study study|nmod|END_ENTITY	Comparative study of CYP1A1 induction by 3-methylcholanthrene in various human hepatic and epidermal cell types .
20732958	0	3-methylcholanthrene	225,245	CYP1A1	176,182	3-methylcholanthrene	CYP1A1	MESH:D008748	1543	Chemical	Gene	augmented|nmod|START_ENTITY augmented|dobj|activation activation|compound|END_ENTITY	Disruption of the gene for CYP1A2 , which is expressed primarily in liver , leads to differential regulation of hepatic and pulmonary mouse CYP1A1 expression and augmented human CYP1A1 transcriptional activation in response to 3-methylcholanthrene in vivo .
9388470	0	3-methylcholanthrene	76,96	CYP1A1	61,67	3-methylcholanthrene	CYP1A1	MESH:D008748	1543	Chemical	Gene	suppresses|nmod|START_ENTITY suppresses|dobj|induction induction|nmod|mRNA mRNA|compound|END_ENTITY	Upstream_stimulatory_factor_1 -LRB- USF1 -RRB- suppresses induction of CYP1A1 mRNA by 3-methylcholanthrene -LRB- MC -RRB- in HepG2 cells .
12438513	0	3-methylcholanthrene	92,112	CYP1A2	133,139	3-methylcholanthrene	CYP1A2	MESH:D008748	13077(Tax:10090)	Chemical	Gene	P4501A|advcl|START_ENTITY P4501A|nmod|mice mice|acl|lacking lacking|dobj|gene gene|compound|END_ENTITY	Differential regulation of expression of hepatic and pulmonary cytochrome P4501A enzymes by 3-methylcholanthrene in mice lacking the CYP1A2 gene .
7794261	0	3-methylcholanthrene	71,91	CYP1A2	0,6	3-methylcholanthrene	CYP1A2	MESH:D008748	24297(Tax:10116)	Chemical	Gene	inducers|dep|START_ENTITY treated|nmod|inducers treated|nsubj|END_ENTITY	CYP1A2 and 2E1 expression in rat liver treated with combined inducers -LRB- 3-methylcholanthrene and ethanol -RRB- .
8120057	0	3-methylcholanthrene	39,59	CYP1A2	10,16	3-methylcholanthrene	CYP1A2	MESH:D008748	1544	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	The human CYP1A2 gene and induction by 3-methylcholanthrene .
9705900	0	3-methylcholanthrene	32,52	CYP1A5	75,81	3-methylcholanthrene	CYP1A5	MESH:D008748	396051(Tax:9031)	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Developmental regulation of the 3-methylcholanthrene - and dioxin-inducible CYP1A5 gene in chick embryo liver in vivo .
23846873	0	3-methylcholanthrene	49,69	CYP3A	32,37	3-methylcholanthrene	CYP3A	MESH:D008748	13112(Tax:10090)	Chemical	Gene	protein|nmod|START_ENTITY protein|compound|END_ENTITY	Downregulation of mouse hepatic CYP3A protein by 3-methylcholanthrene does not require cytochrome P450-dependent metabolism .
2747632	0	3-methylcholanthrene	76,96	Cyp1A2	21,27	3-methylcholanthrene	Cyp1A2	MESH:D008748	1544	Chemical	Gene	elements|amod|START_ENTITY contains|dobj|elements contains|nsubj|gene gene|compound|END_ENTITY	The human cytochrome Cyp1A2 gene contains regulatory elements responsive to 3-methylcholanthrene .
15885734	0	3-methylcholanthrene	123,143	Cyp1a1	13,19	3-methylcholanthrene	Cyp1a1	MESH:D008748	13076(Tax:10090)	Chemical	Gene	exposure|nmod|START_ENTITY adducts|advcl|exposure adducts|nsubj|Induction Induction|nmod|END_ENTITY	Induction of Cyp1a1 and Cyp1b1 and formation of DNA adducts in C57BL/6 , Balb/c , and F1 mice following in utero exposure to 3-methylcholanthrene .
20595379	0	3-methylcholanthrene	143,163	Cyp1a2	88,94	3-methylcholanthrene	Cyp1a2	MESH:D008748	13077(Tax:10090)	Chemical	Gene	required|advcl|START_ENTITY required|nsubj|elements elements|nmod|5 5|dep|region region|nmod|gene gene|compound|END_ENTITY	Regulatory xenobiotic responsive elements in the distal 5 ' - flanking region of the mouse Cyp1a2 gene required for transcriptional activation by 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin .
3002384	0	3-methylcholanthrene	30,50	Cytochrome_P-450	0,16	3-methylcholanthrene	Cytochrome P-450	MESH:D008748	13079(Tax:10090)	Chemical	Gene	induction|nmod|START_ENTITY induction|nsubj|END_ENTITY	Cytochrome_P-450 induction by 3-methylcholanthrene and its antagonism by 2,2-dimethyl-5-t-butyl-1 ,3 - benzodioxole .
12110372	0	3-methylcholanthrene	73,93	MRP2	127,131	3-methylcholanthrene	MRP2	MESH:D008748	25303(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Coordinate regulation of UDP-glucuronosyltransferase UGT1A6 induction by 3-methylcholanthrene and multidrug resistance protein MRP2 expression by dexamethasone in primary rat hepatocytes .
16359657	0	3-methylcholanthrene	48,68	aryl-hydrocarbon_receptor	73,98	3-methylcholanthrene	aryl-hydrocarbon receptor	MESH:D008748	196	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Antiproliferative and antiangiogenic effects of 3-methylcholanthrene , an aryl-hydrocarbon_receptor agonist , in human umbilical vascular endothelial cells .
18022818	0	3-methylcholanthrene	49,69	aryl-hydrocarbon_receptor	74,99	3-methylcholanthrene	aryl-hydrocarbon receptor	MESH:D008748	196	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Molecular mechanisms of p21 and p27 induction by 3-methylcholanthrene , an aryl-hydrocarbon_receptor agonist , involved in antiproliferation of human umbilical vascular endothelial cells .
6926812	0	3-methylcholanthrene	11,31	cholesterol_7_alpha-hydroxylase	43,74	3-methylcholanthrene	cholesterol 7 alpha-hydroxylase	MESH:D008748	25428(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of 3-methylcholanthrene and DDT on cholesterol_7_alpha-hydroxylase in rats .
6411328	0	3-methylcholanthrene	143,163	cytochrome_P-450	121,137	3-methylcholanthrene	cytochrome P-450	MESH:D008748	25251(Tax:10116)	Chemical	Gene	rats|amod|START_ENTITY END_ENTITY|nmod|rats	Antibody inhibition of oxidative activation and inactivation of the carcinogen 2-acetylaminofluorene by purified hepatic cytochrome_P-450 from 3-methylcholanthrene pretreated rats .
19889059	0	3-methylcholanthrene	0,20	cytochrome_P450	57,72	3-methylcholanthrene	cytochrome P450	MESH:D008748	25251(Tax:10116)	Chemical	Gene	modulate|nsubj|START_ENTITY modulate|dobj|expression expression|amod|END_ENTITY	3-methylcholanthrene and benzo -LRB- a -RRB- pyrene modulate cardiac cytochrome_P450 gene expression and arachidonic_acid metabolism in male Sprague_Dawley_rats .
20051482	0	3-methylcholanthrene	70,90	cytochrome_P4501A1	24,42	3-methylcholanthrene	cytochrome P4501A1	MESH:D008748	1543	Chemical	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	Persistent induction of cytochrome_P4501A1 in human hepatoma cells by 3-methylcholanthrene : evidence for sustained transcriptional activation of the CYP1A1 promoter .
11096091	1	3-methylcholanthrene	137,157	mdr1	124,128	3-methylcholanthrene	mdr1	MESH:D008748	110357(Tax:10090)	Chemical	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	AhR nuclear translocator - and p53-mediated induction of the murine multidrug resistance mdr1 gene by 3-methylcholanthrene and benzo -LRB- a -RRB- pyrene in hepatoma cells .
18022818	0	3-methylcholanthrene	49,69	p21	24,27	3-methylcholanthrene	p21	MESH:D008748	644914	Chemical	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Molecular mechanisms of p21 and p27 induction by 3-methylcholanthrene , an aryl-hydrocarbon_receptor agonist , involved in antiproliferation of human umbilical vascular endothelial cells .
11401427	0	3-methylcrotonyl-CoA	35,55	MCCA	74,78	3-methylcrotonyl-CoA	MCCA	CHEBI:15486	56922	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Human biotin-containing subunit of 3-methylcrotonyl-CoA carboxylase gene -LRB- MCCA -RRB- : cDNA sequence , genomic organization , localization to chromosomal band 3q27 , and expression .
11406611	0	3-methylcrotonyl-CoA	93,113	MCCA	21,25	3-methylcrotonyl-CoA	MCCA	CHEBI:15486	56922	Chemical	Gene	cause|nmod|START_ENTITY reveal|dobj|cause reveal|nsubj|Cloning Cloning|nmod|END_ENTITY	Cloning of the human MCCA and MCCB genes and mutations therein reveal the molecular cause of 3-methylcrotonyl-CoA : carboxylase deficiency .
16835865	0	3-methylcrotonyl-CoA	22,42	MCCA	95,99	3-methylcrotonyl-CoA	MCCA	CHEBI:15486	56922	Chemical	Gene	deficiency|amod|START_ENTITY screening|nmod|deficiency screening|dep|heterogeneity heterogeneity|nmod|mutations mutations|compound|END_ENTITY	Newborn screening for 3-methylcrotonyl-CoA carboxylase deficiency : population heterogeneity of MCCA and MCCB mutations and impact on risk assessment .
20864530	0	3-methylhistidine	8,25	Rpl3	66,70	3-methylhistidine	Rpl3	CHEBI:70959	854229(Tax:4932)	Chemical	Gene	modification|amod|START_ENTITY modification|nmod|END_ENTITY	A novel 3-methylhistidine modification of yeast ribosomal protein Rpl3 is dependent upon the YIL110W methyltransferase .
9667816	0	3-morpholino_sydnonimine	78,102	prolactin	106,115	3-morpholino sydnonimine	prolactin	MESH:C002385	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Methylene_blue inhibits stimulatory effect of sodium_nitroprusside but not of 3-morpholino_sydnonimine on prolactin secretion in freely moving male rats .
23169608	0	3-n-butylphthalide	35,53	cytochrome_P450s_and_alcohol_dehydrogenase	83,125	3-n-butylphthalide	cytochrome P450s and alcohol dehydrogenase	MESH:C027125	10327	Chemical	Gene	Metabolism|nmod|START_ENTITY Metabolism|dep|role role|nmod|END_ENTITY	Metabolism and pharmacokinetics of 3-n-butylphthalide -LRB- NBP -RRB- in humans : the role of cytochrome_P450s_and_alcohol_dehydrogenase in biotransformation .
8960880	0	3-nitro-L-tyrosine	26,44	angiotensin_II	85,99	3-nitro-L-tyrosine	angiotensin II	CHEBI:44454	24179(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|nmod|END_ENTITY	The peroxynitrite product 3-nitro-L-tyrosine attenuates the hemodynamic responses to angiotensin_II in vivo .
9416333	0	3-nitropropionic_acid	70,91	HSP70	32,37	3-nitropropionic acid	HSP70	MESH:C015392	3308	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Blood-brain barrier disruption , HSP70 expression and apoptosis due to 3-nitropropionic_acid , a mitochondrial toxin .
15911279	0	3-phenyl-3H-quinazolin-4-one	49,77	CXCR3	93,98	3-phenyl-3H-quinazolin-4-one	CXCR3	MESH:C504934	2833	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Synthesis and structure-activity relationship of 3-phenyl-3H-quinazolin-4-one derivatives as CXCR3 chemokine receptor antagonists .
22189275	0	3-phenylpiperidine-4-carboxamides	6,39	neurokinin-1_receptor	80,101	3-phenylpiperidine-4-carboxamides	neurokinin-1 receptor	null	100135626(Tax:10141)	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|amod|END_ENTITY	Novel 3-phenylpiperidine-4-carboxamides as highly potent and orally long-acting neurokinin-1_receptor antagonists with reduced CYP3A induction .
12926252	0	3-phenylprop-2-ynylamines	6,31	squalene_epoxidase	59,77	3-phenylprop-2-ynylamines	squalene epoxidase	null	6713	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Novel 3-phenylprop-2-ynylamines as inhibitors of mammalian squalene_epoxidase .
16034819	0	3-phosphoglycerate	34,52	PGK1	66,70	3-phosphoglycerate	PGK1	MESH:C005156	850370(Tax:4932)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular characterization of the 3-phosphoglycerate kinase gene -LRB- PGK1 -RRB- from the methylotrophic yeast Pichia_pastoris .
8075252	0	3-phosphoglycerate	104,122	glyceraldehyde-3-phosphate_dehydrogenase	58,98	3-phosphoglycerate	glyceraldehyde-3-phosphate dehydrogenase	MESH:C005156	2597	Chemical	Gene	kinase|amod|START_ENTITY END_ENTITY|nmod|kinase	-LSB- Glycolytic enzymes in human erythrocytes : association of glyceraldehyde-3-phosphate_dehydrogenase with 3-phosphoglycerate kinase -RSB- .
16466921	0	3-piperidinopropan-1-ol	21,44	histamine_H3_receptor	62,83	3-piperidinopropan-1-ol	histamine H3 receptor	null	11255	Chemical	Gene	derivatives|nmod|START_ENTITY derivatives|nmod|antagonists antagonists|amod|END_ENTITY	Ether derivatives of 3-piperidinopropan-1-ol as non-imidazole histamine_H3_receptor antagonists .
26018800	0	3-polyunsaturated_fatty_acids	2,31	lipoprotein-associated_phospholipase_A2	41,80	3-polyunsaturated fatty acids	lipoprotein-associated phospholipase A2	null	7941	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	3-polyunsaturated_fatty_acids suppress lipoprotein-associated_phospholipase_A2 expression in macrophages and animal models .
21163664	0	3-pyridylacetamide	24,42	dipeptidyl_peptidase_IV	58,81	3-pyridylacetamide	dipeptidyl peptidase IV	null	1803	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Design and synthesis of 3-pyridylacetamide derivatives as dipeptidyl_peptidase_IV -LRB- DPP-4 -RRB- inhibitors targeting a bidentate interaction with Arg125 .
10987429	0	3-pyridylethanolamine	18,39	beta3	40,45	3-pyridylethanolamine	beta3	null	1934	Chemical	Gene	agonists|amod|START_ENTITY agonists|amod|END_ENTITY	Potent , selective 3-pyridylethanolamine beta3 adrenergic receptor agonists possessing a thiazole_benzenesulfonamide pharmacophore .
14552782	0	3-quinolinecarbonitriles	76,100	Src	122,125	3-quinolinecarbonitriles	Src	null	6714	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Investigation of the effect of varying the 4-anilino and 7-alkoxy groups of 3-quinolinecarbonitriles on the inhibition of Src kinase activity .
24696848	0	3-rhamnosylquercetin	17,37	sPLA_2	122,128	3-rhamnosylquercetin	sPLA 2	null	8399	Chemical	Gene	START_ENTITY|nmod|effects effects|nmod|END_ENTITY	An evaluation of 3-rhamnosylquercetin , a glycosylated form of quercetin , against the myotoxic and edematogenic effects of sPLA_2 from Crotalus durissus terrificus .
20117004	0	3-substituted_indolin-2-one	75,102	RET	103,106	3-substituted indolin-2-one	RET	null	5979	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Synthesis , structure-activity relationship and crystallographic studies of 3-substituted_indolin-2-one RET inhibitors .
16476457	0	3-sulfamates	70,82	estrone_sulfatase	14,31	3-sulfamates	estrone sulfatase	null	412	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of estrone_sulfatase by aromatase inhibitor-based estrogen 3-sulfamates .
19188834	0	3-thienylalanine-ornithine-proline	10,44	angiotensin-converting_enzyme	68,97	3-thienylalanine-ornithine-proline	angiotensin-converting enzyme	MESH:C540584	24310(Tax:10116)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Effect of 3-thienylalanine-ornithine-proline , new sulfur-containing angiotensin-converting_enzyme inhibitor on blood pressure and oxidative stress in spontaneously hypertensive rats .
17127175	0	3-trans-FCWAY	92,105	5-HT1A_receptor	64,79	3-trans-FCWAY	5-HT1A receptor	null	3350	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|amod|END_ENTITY	Species differences in metabolites of PET ligands : serotonergic 5-HT1A_receptor antagonists 3-trans-FCWAY and 3-cis-FCWAY .
11564890	0	36-amino-acid	2,15	CIITA	26,31	36-amino-acid	CIITA	null	4261	Chemical	Gene	region|amod|START_ENTITY region|nmod|END_ENTITY	A 36-amino-acid region of CIITA is an effective inhibitor of CBP : novel mechanism of gamma interferon-mediated suppression of collagen alpha -LRB- 2 -RRB- -LRB- I -RRB- and other promoters .
9354445	0	3BIT	22,26	CD22	73,77	3BIT	CD22	null	933	Chemical	Gene	therapy|nmod|START_ENTITY therapy|dep|END_ENTITY	Systemic therapy with 3BIT , a triple combination cocktail of anti-CD19 , - CD22 , and - CD38-saporin immunotoxins , is curative of human B-cell_lymphoma in severe combined immunodeficient mice .
6425862	0	3H-arachidonic_acid	65,84	superoxide_dismutase	14,34	3H-arachidonic acid	superoxide dismutase	null	6647	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of superoxide_dismutase and catalase on metabolism of 3H-arachidonic_acid by washed platelets .
17686476	0	3H-serotonin	0,12	insulin	40,47	3H-serotonin	insulin	null	3630	Chemical	Gene	START_ENTITY|nmod|marker marker|nmod|END_ENTITY	3H-serotonin as a marker of oscillatory insulin secretion in clonal beta-cells -LRB- INS-1 -RRB- .
12604227	0	3_3alpha-hydroxysteroid	19,42	AKR1C2	58,64	3 3alpha-hydroxysteroid	AKR1C2	null	1646	Chemical	Gene	dehydrogenase|amod|START_ENTITY Role|nmod|dehydrogenase Role|appos|END_ENTITY	Role of human type 3_3alpha-hydroxysteroid dehydrogenase -LRB- AKR1C2 -RRB- in androgen metabolism of prostate_cancer cells .
3166980	0	3_beta-Hydroxy-5_beta-steroid	0,29	alcohol_dehydrogenase	68,89	3 beta-Hydroxy-5 beta-steroid	alcohol dehydrogenase	null	10327	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	3_beta-Hydroxy-5_beta-steroid dehydrogenase activity of human liver alcohol_dehydrogenase is specific to gamma-subunits .
8103495	0	3_beta-hydroxysteroid	15,36	3_beta-HSD	52,62	3 beta-hydroxysteroid	3 beta-HSD	CHEBI:36836	3283	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|dep|END_ENTITY	Alterations in 3_beta-hydroxysteroid dehydrogenase -LRB- 3_beta-HSD -RRB- mRNA accumulation induced by beta-adrenergic stimulation in cultured porcine granulosa cells .
9420856	0	3_beta-hydroxysteroid	26,47	insulin	15,22	3 beta-hydroxysteroid	insulin	CHEBI:36836	3630	Chemical	Gene	expression|amod|START_ENTITY effects|nmod|expression effects|nmod|END_ENTITY	The effects of insulin on 3_beta-hydroxysteroid dehydrogenase expression in human luteinized granulosa cells .
17475203	0	3alpha-hydroxysteroid	19,40	AKR1C17	56,63	3alpha-hydroxysteroid	AKR1C17	CHEBI:36835	498790(Tax:10116)	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	Rat NAD + - dependent 3alpha-hydroxysteroid dehydrogenase -LRB- AKR1C17 -RRB- : a member of the aldo-keto reductase family highly expressed in kidney cytosol .
1166086	0	3beta-hydroxy-delta5-steroid	104,132	oxidoreductase	133,147	3beta-hydroxy-delta5-steroid	oxidoreductase	null	7296	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	Induced adrenal_and_ovarian_enlargement in nursing mothers by a single mug injection to their pups of a 3beta-hydroxy-delta5-steroid oxidoreductase inhibitor .
12050213	0	3beta-hydroxysteroid	88,108	3beta-HSD	124,133	3beta-hydroxysteroid	3beta-HSD	CHEBI:36836	3283	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|dep|END_ENTITY	A novel nonstop mutation in the stop codon and a novel missense mutation in the type II 3beta-hydroxysteroid dehydrogenase -LRB- 3beta-HSD -RRB- gene causing , respectively , nonclassic and classic 3beta-HSD deficiency congenital_adrenal_hyperplasia .
9862144	1	3beta-hydroxysteroid	141,161	3beta-HSD	177,186	3beta-hydroxysteroid	3beta-HSD	CHEBI:36836	3283	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|dep|END_ENTITY	The enzyme complex 3beta-hydroxysteroid dehydrogenase -LRB- 3beta-HSD -RRB- is involved in the biosynthesis of all classes of active steroids .
15131259	0	3beta-hydroxysteroid	116,136	HSD3B1	157,163	3beta-hydroxysteroid	HSD3B1	CHEBI:36836	3283	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Transcription_enhancer_factor-5 and a GATA-like protein determine placental-specific expression of the Type I human 3beta-hydroxysteroid dehydrogenase gene , HSD3B1 .
10599696	0	3beta-hydroxysteroid	40,60	HSD3B2	128,134	3beta-hydroxysteroid	HSD3B2	CHEBI:36836	3284	Chemical	Gene	deficiency|amod|START_ENTITY basis|nmod|deficiency basis|dep|identification identification|nmod|mutations mutations|nmod|patients patients|nummod|END_ENTITY	New insight into the molecular basis of 3beta-hydroxysteroid dehydrogenase deficiency : identification of eight mutations in the HSD3B2 gene eleven patients from seven new families and comparison of the functional properties of twenty-five mutant enzymes .
10651755	0	3beta-hydroxysteroid	25,45	HSD3B2	61,67	3beta-hydroxysteroid	HSD3B2	CHEBI:36836	3284	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations in the type II 3beta-hydroxysteroid dehydrogenase -LRB- HSD3B2 -RRB- gene can cause premature_pubarche in girls .
10973654	0	3beta-hydroxysteroid	26,46	HSD3B2	67,73	3beta-hydroxysteroid	HSD3B2	CHEBI:36836	3284	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genotyping of the type II 3beta-hydroxysteroid dehydrogenase gene -LRB- HSD3B2 -RRB- in women with hirsutism and elevated ACTH-stimulated delta -LRB- 5 -RRB- - steroids .
10232649	0	4,5-Diaryloxazole	0,17	cyclooxygenase-2	32,48	4,5-Diaryloxazole	cyclooxygenase-2	null	5743	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	4,5-Diaryloxazole inhibitors of cyclooxygenase-2 -LRB- COX-2 -RRB- .
15713403	0	4,5-diarylimidazoles	26,46	CB1	56,59	4,5-diarylimidazoles	CB1	null	1268	Chemical	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	Synthesis and activity of 4,5-diarylimidazoles as human CB1 receptor inverse agonists .
18020435	0	4,5-diarylisoxazole	0,19	Hsp90	20,25	4,5-diarylisoxazole	Hsp90	null	3320	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	4,5-diarylisoxazole Hsp90 chaperone inhibitors : potential therapeutic agents for the treatment of cancer .
25941546	0	4,6-Diarylaminothiazines	0,24	BACE1	28,33	4,6-Diarylaminothiazines	BACE1	null	23621	Chemical	Gene	START_ENTITY|nmod|Inhibitors Inhibitors|compound|END_ENTITY	4,6-Diarylaminothiazines as BACE1 Inhibitors and Their Use for the Reduction of Beta-Amyloid Production .
2460774	0	4,alpha-dimethyl-m-tyramine	24,51	monoamine_oxidase	113,130	4,alpha-dimethyl-m-tyramine	monoamine oxidase	MESH:C001047	29253(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Selective inhibition by 4,alpha-dimethyl-m-tyramine -LRB- H77/77 -RRB- and 4-methyl-alpha-ethyl-m-tyramine -LRB- H75/12 -RRB- of the monoamine_oxidase within serotonergic and noradrenergic neurons in the rat brain .
9767653	0	4-Alkynylphenyl_imidazolylpropyl_ethers	0,39	histamine_H3-receptor	53,74	4-Alkynylphenyl imidazolylpropyl ethers	histamine H3-receptor	null	11255	Chemical	Gene	START_ENTITY|nmod|antagonists antagonists|amod|END_ENTITY	4-Alkynylphenyl_imidazolylpropyl_ethers as selective histamine_H3-receptor antagonists with high oral central nervous system activity .
24673130	0	4-Amino-pyridopyrimidine	23,47	MAP4K4	62,68	4-Amino-pyridopyrimidine	MAP4K4	null	9448	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Discovery of selective 4-Amino-pyridopyrimidine inhibitors of MAP4K4 using fragment-based lead identification and optimization .
12113833	0	4-Aminoarylguanidine	0,20	urokinase-type_plasminogen_activator	80,116	4-Aminoarylguanidine	urokinase-type plasminogen activator	null	5328	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	4-Aminoarylguanidine and 4-aminobenzamidine derivatives as potent and selective urokinase-type_plasminogen_activator inhibitors .
18842621	0	4-Aminobiphenyl	0,15	NAT2	34,38	4-Aminobiphenyl	NAT2	MESH:C006757	116632(Tax:10116)	Chemical	Gene	downregulation|amod|START_ENTITY downregulation|nmod|END_ENTITY	4-Aminobiphenyl downregulation of NAT2 acetylator genotype-dependent N - and O-acetylation of aromatic_and_heterocyclic_amine carcinogens in primary mammary epithelial cell cultures from rapid and slow acetylator rats .
19228266	0	4-Aminoethylamino-emodin	0,24	GSK-3beta	54,63	4-Aminoethylamino-emodin	GSK-3beta	MESH:C552996	2932	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	4-Aminoethylamino-emodin -- a novel potent inhibitor of GSK-3beta -- acts as an insulin-sensitizer avoiding downstream effects of activated beta-catenin .
9882198	2	4-Aminomethylbenzoic_acid	118,143	PepT1	298,303	4-Aminomethylbenzoic acid	PepT1	MESH:C015668	117261(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|expressing expressing|dobj|END_ENTITY	4-Aminomethylbenzoic_acid , a molecule which mimics the special configuration of a dipeptide , competitively inhibits peptide influx in both Xenopus_Laevis oocytes expressing rabbit PepT1 and through PepT1 in rat renal brush border membrane vesicles .
19915712	0	4-Aminopyridine	11,26	hERG	37,41	4-Aminopyridine	hERG	MESH:D015761	2078	Chemical	Gene	Effects|nmod|START_ENTITY Effects|acl|END_ENTITY	Effects of 4-Aminopyridine on Cloned hERG Channels Expressed in Mammalian Cells .
20643547	0	4-Anilino-6-phenyl-quinoline	0,28	mitogen_activated_protein_kinase-activated_protein_kinase_2	43,102	4-Anilino-6-phenyl-quinoline	mitogen activated protein kinase-activated protein kinase 2	null	9261	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	4-Anilino-6-phenyl-quinoline inhibitors of mitogen_activated_protein_kinase-activated_protein_kinase_2 -LRB- MK2 -RRB- .
18815050	0	4-Anilino-7-alkenylquinoline-3-carbonitriles	0,44	MEK1	55,59	4-Anilino-7-alkenylquinoline-3-carbonitriles	MEK1	null	5604	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	4-Anilino-7-alkenylquinoline-3-carbonitriles as potent MEK1 kinase inhibitors .
10230640	0	4-Aryl-2-anilinopyrimidines	0,27	corticotropin-releasing_hormone	31,62	4-Aryl-2-anilinopyrimidines	corticotropin-releasing hormone	null	1392	Chemical	Gene	START_ENTITY|nmod|antagonists antagonists|amod|END_ENTITY	4-Aryl-2-anilinopyrimidines as corticotropin-releasing_hormone -LRB- CRH -RRB- antagonists .
17481894	0	4-Aryl-5-cyano-2-aminopyrimidines	0,33	VEGF-R2	37,44	4-Aryl-5-cyano-2-aminopyrimidines	VEGF-R2	null	16542(Tax:10090)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	4-Aryl-5-cyano-2-aminopyrimidines as VEGF-R2 inhibitors : synthesis and biological evaluation .
24900425	0	4-Azetidinyl-1-thiazoyl-cyclohexane	15,50	CCR2	51,55	4-Azetidinyl-1-thiazoyl-cyclohexane	CCR2	null	484790(Tax:9615)	Chemical	Gene	Antagonist|amod|START_ENTITY Antagonist|compound|END_ENTITY	Discovery of a 4-Azetidinyl-1-thiazoyl-cyclohexane CCR2 Antagonist as a Development Candidate .
24153205	0	4-Bicyclic_heteroaryl-piperidine	0,32	Stearoyl-CoA_desaturase-1	76,101	4-Bicyclic heteroaryl-piperidine	Stearoyl-CoA desaturase-1	null	20249(Tax:10090)	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	4-Bicyclic_heteroaryl-piperidine derivatives as potent , orally bioavailable Stearoyl-CoA_desaturase-1 -LRB- SCD1 -RRB- inhibitors .
8605229	0	4-Chloro-m-cresol	0,17	skeletal_muscle_ryanodine_receptor	58,92	4-Chloro-m-cresol	skeletal muscle ryanodine receptor	null	6261	Chemical	Gene	START_ENTITY|appos|activator activator|nmod|END_ENTITY	4-Chloro-m-cresol , a potent and specific activator of the skeletal_muscle_ryanodine_receptor .
23624712	0	4-Chlorobenzoyl_berbamine	0,25	IL-6	113,117	4-Chlorobenzoyl berbamine	IL-6	MESH:C548958	3569	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|pathway pathway|compound|END_ENTITY	4-Chlorobenzoyl_berbamine , a novel berbamine derivative , induces apoptosis in multiple myeloma cells through the IL-6 signal transduction pathway and increases FOXO3a-Bim expression .
14599013	0	4-Fluorinated_L-lysine	0,22	i-NOS	44,49	4-Fluorinated L-lysine	i-NOS	null	4843	Chemical	Gene	analogs|amod|START_ENTITY analogs|nmod|inhibitors inhibitors|amod|END_ENTITY	4-Fluorinated_L-lysine analogs as selective i-NOS inhibitors : methodology for introducing fluorine into the lysine side chain .
20501066	0	4-Fluoro-3-nitrophenyl_azide	0,28	monoamine_oxidase_B	66,85	4-Fluoro-3-nitrophenyl azide	monoamine oxidase B	MESH:C007753	4129	Chemical	Gene	sites|amod|START_ENTITY sites|nmod|END_ENTITY	4-Fluoro-3-nitrophenyl_azide binding sites on purified beef liver monoamine_oxidase_B .
17044020	6	4-HPR	1292,1297	TGF-beta2	1306,1315	4-HPR	TGF-beta1	MESH:D017313	7040	Chemical	Gene	Treatment|nmod|START_ENTITY Treatment|acl|induced induced|dobj|expression expression|compound|END_ENTITY	Treatment of HaCaT cells with 4-HPR induced TGF-beta2 expression and an increase in the amount of active TGF-beta in the culture medium .
26032047	0	4-Heteroaryl-Antipyrines	6,30	DPP-IV	34,40	4-Heteroaryl-Antipyrines	DPP-IV	null	1803	Chemical	Gene	START_ENTITY|nmod|Inhibitors Inhibitors|compound|END_ENTITY	Novel 4-Heteroaryl-Antipyrines as DPP-IV Inhibitors .
21424127	0	4-Hexylresorcinol	0,17	transglutaminase-2	27,45	4-Hexylresorcinol	transglutaminase-2	MESH:D006604	7052	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	4-Hexylresorcinol inhibits transglutaminase-2 activity and has synergistic effects along with cisplatin in KB cells .
9783727	0	4-Hydroxy-17-methylincisterol	0,29	DNA_polymerase-alpha	47,67	4-Hydroxy-17-methylincisterol	DNA polymerase-alpha	MESH:C115169	5422	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|activity activity|amod|END_ENTITY	4-Hydroxy-17-methylincisterol , an inhibitor of DNA_polymerase-alpha activity and the growth of human cancer cells in vitro .
24711740	0	4-Hydroxy-2-nonenal	0,19	AKT	52,55	4-Hydroxy-2-nonenal	AKT	MESH:C027576	207	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|inhibiting inhibiting|dobj|END_ENTITY	4-Hydroxy-2-nonenal induces apoptosis by inhibiting AKT signaling in human osteosarcoma cells .
15050414	0	4-Hydroxy_estradiol	0,19	hypoxia-inducible_factor_1alpha	70,101	4-Hydroxy estradiol	hypoxia-inducible factor 1alpha	MESH:C014036	3091	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	4-Hydroxy_estradiol but not 2-hydroxy_estradiol induces expression of hypoxia-inducible_factor_1alpha and vascular_endothelial_growth_factor_A through phosphatidylinositol 3-kinase/Akt/FRAP pathway in OVCAR-3 and A2780-CP70 human ovarian_carcinoma cells .
24361890	0	4-Hydroxy_hexenal	0,17	heme_oxygenase-1	101,117	4-Hydroxy hexenal	heme oxygenase-1	MESH:C063409	15368(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	4-Hydroxy_hexenal derived from dietary n-3 polyunsaturated_fatty_acids induces anti-oxidative enzyme heme_oxygenase-1 in multiple organs .
19837106	0	4-Hydroxynonenal	0,16	MMP-9	26,31	4-Hydroxynonenal	MMP-9	MESH:C027576	17395(Tax:10090)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|compound|END_ENTITY	4-Hydroxynonenal enhances MMP-9 production in murine macrophages via 5-lipoxygenase-mediated activation of ERK and p38_MAPK .
21449565	0	4-Hydroxynonenal	0,16	SIRT3	26,31	4-Hydroxynonenal	SIRT3	MESH:C027576	64384(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	4-Hydroxynonenal inhibits SIRT3 via thiol-specific modification .
26453921	0	4-Hydroxynonenal	0,16	Src	27,30	4-Hydroxynonenal	Src	MESH:C027576	6714	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	4-Hydroxynonenal activates Src through a non-canonical pathway that involves EGFR/PTP1B .
26466383	0	4-Hydroxynonenal	34,50	Src	0,3	4-Hydroxynonenal	Src	MESH:C027576	83805(Tax:10116)	Chemical	Gene	p38|amod|START_ENTITY Activation|nmod|p38 Activation|compound|END_ENTITY	Src Tyrosine Kinase Activation by 4-Hydroxynonenal Upregulates p38 , ERK/AP -1 Signaling and COX-2 Expression in YPEN-1 Cells .
1516044	0	4-Hydroxynonenal	0,16	c-myc	76,81	4-Hydroxynonenal	c-myc	MESH:C027576	4609	Chemical	Gene	START_ENTITY|appos|product product|nmod|peroxidation peroxidation|acl:relcl|modulates modulates|dobj|expression expression|amod|END_ENTITY	4-Hydroxynonenal , a product of cellular lipid peroxidation , which modulates c-myc and globin gene expression in K562 erythroleukemic cells .
15649648	0	4-Hydroxynonenal	0,16	gamma-glutamyl_transpeptidase	27,56	4-Hydroxynonenal	gamma-glutamyl transpeptidase	MESH:C027576	116568(Tax:10116)	Chemical	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	4-Hydroxynonenal increases gamma-glutamyl_transpeptidase gene expression through mitogen-activated protein kinase pathways .
16195535	0	4-Hydroxynonenal	0,16	gamma-glutamyl_transpeptidase	29,58	4-Hydroxynonenal	gamma-glutamyl transpeptidase	MESH:C027576	116568(Tax:10116)	Chemical	Gene	induces|dep|START_ENTITY induces|dobj|END_ENTITY	4-Hydroxynonenal induces rat gamma-glutamyl_transpeptidase through mitogen-activated protein kinase-mediated electrophile response element/nuclear factor erythroid 2-related factor 2 signaling .
26476300	0	4-Hydroxynonenal	48,64	glutathione_S-transferases	20,46	4-Hydroxynonenal	glutathione S-transferases	MESH:C027576	373156	Chemical	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	Antioxidant role of glutathione_S-transferases : 4-Hydroxynonenal , a key molecule in stress-mediated signaling .
9142649	0	4-Hydroxynonenal	0,16	interleukin-1_beta_converting_enzyme	26,62	4-Hydroxynonenal	interleukin-1 beta converting enzyme	MESH:C027576	834	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	4-Hydroxynonenal inhibits interleukin-1_beta_converting_enzyme .
3107552	0	4-MA	68,72	3_beta_HSD	18,28	4-MA	3 beta HSD	null	3283	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|activity activity|amod|END_ENTITY	The inhibition of 3_beta_HSD activity in porcine granulosa cells by 4-MA , a potent 5_alpha-reductase inhibitor .
3107552	0	4-MA	68,72	5_alpha-reductase	83,100	4-MA	5 alpha-reductase	null	6715	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	The inhibition of 3_beta_HSD activity in porcine granulosa cells by 4-MA , a potent 5_alpha-reductase inhibitor .
1353376	0	4-Methoxytranylcypromine	0,24	monoamine_oxidase	28,45	4-Methoxytranylcypromine	monoamine oxidase	MESH:C068589	29253(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	4-Methoxytranylcypromine , a monoamine_oxidase inhibitor : effects on biogenic amines in rat brain following chronic administration .
7546332	0	4-Methylpyrazole	0,16	alcohol_dehydrogenase	21,42	4-Methylpyrazole	alcohol dehydrogenase	MESH:C010238	78959(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	4-Methylpyrazole , an alcohol_dehydrogenase inhibitor , exacerbates alcohol-induced microencephaly during the brain growth spurt .
25304388	0	4-Methylumbelliferone	0,21	thymidine_phosphorylase	68,91	4-Methylumbelliferone	thymidine phosphorylase	MESH:C489431	1890	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|suppressing suppressing|dobj|expression expression|amod|END_ENTITY	4-Methylumbelliferone inhibits ovarian_cancer growth by suppressing thymidine_phosphorylase expression .
15482932	0	4-O-alkyl_quinolone	26,45	GnRH_receptor	57,70	4-O-alkyl quinolone	GnRH receptor	null	2798	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|compound|END_ENTITY	Identification of neutral 4-O-alkyl_quinolone nonpeptide GnRH_receptor antagonists .
21329651	0	4-O-methylascochlorin	0,21	HIF-1a	72,78	4-O-methylascochlorin	HIF-1a	MESH:C031515	3091	Chemical	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	4-O-methylascochlorin , methylated derivative of ascochlorin , stabilizes HIF-1a via AMPK activation .
19635455	0	4-OH_tamoxifen	93,107	protein_tyrosine_phosphatase_1B	15,46	4-OH tamoxifen	protein tyrosine phosphatase 1B	null	5770	Chemical	Gene	Implication|nmod|START_ENTITY Implication|nmod|END_ENTITY	Implication of protein_tyrosine_phosphatase_1B in MCF-7 cell proliferation and resistance to 4-OH_tamoxifen .
22801646	0	4-Phenyl-7-azaindoles	0,21	IKK2	60,64	4-Phenyl-7-azaindoles	IKK2	null	3551	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	4-Phenyl-7-azaindoles as potent , selective and bioavailable IKK2 inhibitors demonstrating good in vivo efficacy .
22069317	0	4-Phenylbutyrate	0,16	Hsp70	28,33	4-Phenylbutyrate	Hsp70	MESH:C075773	3308	Chemical	Gene	stimulates|amod|START_ENTITY END_ENTITY|nsubj|stimulates	4-Phenylbutyrate stimulates Hsp70 expression through the Elp2 component of elongator and STAT-3 in cystic fibrosis epithelial cells .
25011668	0	4-Phenylbutyric_acid	0,20	GLUT4	31,36	4-Phenylbutyric acid	GLUT4	MESH:C075773	6517	Chemical	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	4-Phenylbutyric_acid increases GLUT4 gene expression through suppression of HDAC5 but not endoplasmic reticulum stress .
16690313	0	4-acryloylphenol	37,53	GABA_transaminase	16,33	4-acryloylphenol	GABA transaminase	MESH:C513650	18	Chemical	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of GABA_transaminase by 4-acryloylphenol .
24108070	0	4-alkoxyquinazoline	74,93	VEGFR2	119,125	4-alkoxyquinazoline	VEGFR2	null	3791	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|inhibitors inhibitors|compound|END_ENTITY	Design , synthesis , biological evaluation , and molecular modeling study of 4-alkoxyquinazoline derivatives as potential VEGFR2 kinase inhibitors .
23453068	0	4-alkylamino-7-aryl-3-cyanoquinoline	13,49	LRRK2	50,55	4-alkylamino-7-aryl-3-cyanoquinoline	LRRK2	null	120892	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Discovery of 4-alkylamino-7-aryl-3-cyanoquinoline LRRK2 kinase inhibitors .
16249367	0	4-alkyliden-beta-lactam	118,141	leukocyte_elastase	14,32	4-alkyliden-beta-lactam	leukocyte elastase	null	1991	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of leukocyte_elastase , polymorphonuclear chemoinvasion , and inflammation-triggered pulmonary_fibrosis by a 4-alkyliden-beta-lactam with a galloyl moiety .
14642583	0	4-alkylidene-azetidin-2-ones	0,28	leukocyte_elastase	50,68	4-alkylidene-azetidin-2-ones	leukocyte elastase	null	1991	Chemical	Gene	START_ENTITY|dep|inhibitors inhibitors|nmod|END_ENTITY	4-alkylidene-azetidin-2-ones : novel inhibitors of leukocyte_elastase and gelatinase .
22381049	0	4-alkynyl_pyrazoles	24,43	PDE4	61,65	4-alkynyl pyrazoles	PDE4	null	5141	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Design and synthesis of 4-alkynyl_pyrazoles as inhibitors of PDE4 : a practical access via Pd/C-Cu catalysis .
2100099	0	4-amino-5-imidazole-carboxamide-phosphate	19,60	superoxide_dismutase	111,131	4-amino-5-imidazole-carboxamide-phosphate	superoxide dismutase	null	6647	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	In vitro effect of 4-amino-5-imidazole-carboxamide-phosphate -LRB- AICA-P -RRB- on the enzyme activity and expression of superoxide_dismutase .
9020887	0	4-aminobenzoic_acid_hydrazide	48,77	myeloperoxidase	29,44	4-aminobenzoic acid hydrazide	myeloperoxidase	MESH:C034343	4353	Chemical	Gene	Mechanism|nmod|START_ENTITY Mechanism|nmod|END_ENTITY	Mechanism of inactivation of myeloperoxidase by 4-aminobenzoic_acid_hydrazide .
9029051	0	4-aminobiphenyl	27,42	lipoxygenase	46,58	4-aminobiphenyl	lipoxygenase	MESH:C006757	547836(Tax:3847)	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|nmod|END_ENTITY	Co-oxidative metabolism of 4-aminobiphenyl by lipoxygenase from soybean and human term placenta . -RSB-
9882198	0	4-aminomethylbenzoic_acid	0,25	PepT1	108,113	4-aminomethylbenzoic acid	PepT1	MESH:C015668	117261(Tax:10116)	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	4-aminomethylbenzoic_acid is a non-translocated competitive inhibitor of the epithelial peptide transporter PepT1 .
18646745	0	4-aminopyrazolylpyrimidines	18,45	Trk	70,73	4-aminopyrazolylpyrimidines	Trk	null	4914	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Identification of 4-aminopyrazolylpyrimidines as potent inhibitors of Trk kinases .
10632067	0	4-aminopyridine	30,45	AChE	74,78	4-aminopyridine	AChE	MESH:D015761	43	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Dual-site binding of bivalent 4-aminopyridine - and 4-aminoquinoline-based AChE inhibitors : contribution of the hydrophobic alkylene_tether to monomer and dimer affinities .
27068889	0	4-aminopyrimidine-5-cabaldehyde_oximes	47,85	c-Met	108,113	4-aminopyrimidine-5-cabaldehyde oximes	c-Met	null	4233	Chemical	Gene	evaluation|nmod|START_ENTITY evaluation|nmod|END_ENTITY	Design , synthesis and biological evaluation of 4-aminopyrimidine-5-cabaldehyde_oximes as dual inhibitors of c-Met and VEGFR-2 .
12270190	0	4-anilino-7-phenyl-3-quinolinecarbonitriles	12,55	Src	59,62	4-anilino-7-phenyl-3-quinolinecarbonitriles	Src	null	20779(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Substituted 4-anilino-7-phenyl-3-quinolinecarbonitriles as Src kinase inhibitors .
23973168	0	4-anilino-quinazoline	38,59	epidermal_growth_factor_receptor	75,107	4-anilino-quinazoline	epidermal growth factor receptor	null	1956	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Four-membered heterocycles-containing 4-anilino-quinazoline derivatives as epidermal_growth_factor_receptor -LRB- EGFR -RRB- kinase inhibitors .
15921462	0	4-anilinoquinazoline	21,41	EGFR	55,59	4-anilinoquinazoline	EGFR	null	1956	Chemical	Gene	analogues|amod|START_ENTITY analogues|nmod|inhibitors inhibitors|amod|END_ENTITY	Virtual screening of 4-anilinoquinazoline analogues as EGFR kinase inhibitors : importance of hydrogen bonds in the evaluation of poses and scoring functions .
25468044	0	4-anilinoquinazoline	24,44	EGFR	67,71	4-anilinoquinazoline	EGFR	null	1956	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Identification of novel 4-anilinoquinazoline derivatives as potent EGFR inhibitors both under normoxia and hypoxia .
23640754	0	4-anilinoquinazoline	59,79	epidermal_growth_factor_receptor	105,137	4-anilinoquinazoline	epidermal growth factor receptor	null	1956	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Synthesis , antitumor evaluation and docking study of novel 4-anilinoquinazoline derivatives as potential epidermal_growth_factor_receptor -LRB- EGFR -RRB- inhibitors .
20735208	0	4-anilinoquinoline	79,97	epidermal_growth_factor_receptor	98,130	4-anilinoquinoline	epidermal growth factor receptor	null	1956	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	Rational approach to the synthesis , evaluation , and -LRB- 68 -RRB- ga labeling of a novel 4-anilinoquinoline epidermal_growth_factor_receptor inhibitor as a new imaging agent that selectively targets the epidermal_growth_factor_receptor tyrosine kinase .
12419375	0	4-aryl-pyridine	71,86	glucagon_receptor	87,104	4-aryl-pyridine	glucagon receptor	null	2642	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|compound|END_ENTITY	Integration of optimized substituent patterns to produce highly potent 4-aryl-pyridine glucagon_receptor antagonists .
18783200	0	4-arylamino-3-pyridinecarbonitrile	85,119	PKCtheta	147,155	4-arylamino-3-pyridinecarbonitrile	PKCtheta	null	5588	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Identification , characterization and initial hit-to-lead optimization of a series of 4-arylamino-3-pyridinecarbonitrile as protein_kinase_C_theta -LRB- PKCtheta -RRB- inhibitors .
17851076	0	4-arylcyclohexylalanine	0,23	dipeptidyl_peptidase_IV	86,109	4-arylcyclohexylalanine	dipeptidyl peptidase IV	null	13482(Tax:10090)	Chemical	Gene	analogs|amod|START_ENTITY analogs|nmod|END_ENTITY	4-arylcyclohexylalanine analogs as potent , selective , and orally active inhibitors of dipeptidyl_peptidase_IV .
2538808	0	4-azasteroid	37,49	5_alpha-reductase	63,80	4-azasteroid	5 alpha-reductase	null	6715	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|nmod|END_ENTITY	Hormonal effects of an orally active 4-azasteroid inhibitor of 5_alpha-reductase in humans .
19906465	0	4-azasteroids	31,44	5alpha-reductase	54,70	4-azasteroids	5alpha-reductase	null	6715	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	3D-QSAR studies on unsaturated 4-azasteroids as human 5alpha-reductase inhibitors : a self organizing molecular field analysis approach .
18433114	0	4-benzyl-1H-imidazoles	0,22	histamine_H3_receptor	49,70	4-benzyl-1H-imidazoles	histamine H3 receptor	null	11255	Chemical	Gene	START_ENTITY|nmod|agonists agonists|amod|END_ENTITY	4-benzyl-1H-imidazoles with oxazoline termini as histamine_H3_receptor agonists .
23062824	0	4-benzyl-1H-pyrazol-3-yl_b-d-glucopyranoside	43,87	sodium_glucose_co-transporter_1	124,155	4-benzyl-1H-pyrazol-3-yl b-d-glucopyranoside	sodium glucose co-transporter 1	null	25552(Tax:10116)	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Structure-activity relationship studies of 4-benzyl-1H-pyrazol-3-yl_b-d-glucopyranoside derivatives as potent and selective sodium_glucose_co-transporter_1 -LRB- SGLT1 -RRB- inhibitors with therapeutic activity on postprandial hyperglycemia .
20718420	0	4-carboxymethylpyroglutamic_acid_diamides	12,53	fibroblast_activation_protein	92,121	4-carboxymethylpyroglutamic acid diamides	fibroblast activation protein	null	2191	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Substituted 4-carboxymethylpyroglutamic_acid_diamides as potent and selective inhibitors of fibroblast_activation_protein .
19604582	0	4-chlorobiphenyl	71,87	cytochrome_P450_1A1	13,32	4-chlorobiphenyl	cytochrome P450 1A1	MESH:C006983	1543	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of cytochrome_P450_1A1 in MCF-7 human breast_cancer cells by 4-chlorobiphenyl -LRB- PCB3 -RRB- and the effects of its hydroxylated metabolites on cellular apoptosis .
2144351	0	4-cholesten-3-one	10,27	lecithin-cholesterol_acyltransferase	31,67	4-cholesten-3-one	lecithin-cholesterol acyltransferase	MESH:C000475	24530(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effect of 4-cholesten-3-one on lecithin-cholesterol_acyltransferase activity and the lipid concentration in the serum of normocholesterolaemic and hypercholesterolaemic rats .
6723577	0	4-cyclohexylaniline	49,68	estrogen_synthetase	14,33	4-cyclohexylaniline	estrogen synthetase	MESH:C028146	1588	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of estrogen_synthetase -LRB- aromatase -RRB- by 4-cyclohexylaniline .
3654813	2	4-decyloxytrityl	56,72	aid	85,88	4-decyloxytrityl	aid	null	57379	Chemical	Gene	group|amod|START_ENTITY group|nmod|END_ENTITY	Derivatization with the 4-decyloxytrityl group as an aid in the affinity chromatography of oligo - and polynucleotides .
6156725	0	4-dimethylaminoazobenzene	94,119	alpha-fetoprotein	14,31	4-dimethylaminoazobenzene	alpha-fetoprotein	MESH:D004124	24177(Tax:10116)	Chemical	Gene	injection|nmod|START_ENTITY END_ENTITY|nmod|injection	-LSB- Synthesis of alpha-fetoprotein in rat liver after a single injection of the liver carcinogen 4-dimethylaminoazobenzene and its noncarcinogenic isomer 4-diethylaminoazobenzene -RSB- .
6430584	0	4-dimethylaminophenylazobenzene	124,155	Azoreductase	0,12	4-dimethylaminophenylazobenzene	Azoreductase	CHEBI:17903	24314(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Azoreductase activity of Sprague Dawley and Wistar-derived rats towards both carcinogenic and non-carcinogenic analogues of 4-dimethylaminophenylazobenzene -LRB- DAB -RRB- .
15328885	0	4-halobenzoic_acids	22,41	tyrosinase	100,110	4-halobenzoic acids	tyrosinase	null	7299	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nsubj|effects	Inhibitory effects of 4-halobenzoic_acids on the diphenolase and monophenolase activity of mushroom tyrosinase .
21630706	0	4-halopyridines	76,91	dimethylarginine_dimethylaminohydrolase	20,59	4-halopyridines	dimethylarginine dimethylaminohydrolase	null	23576	Chemical	Gene	inactivation|nmod|START_ENTITY inactivation|amod|END_ENTITY	On the mechanism of dimethylarginine_dimethylaminohydrolase inactivation by 4-halopyridines .
10699375	0	4-hydroxy-2-nonenal	92,111	adenylosuccinate_lyase	61,83	4-hydroxy-2-nonenal	adenylosuccinate lyase	MESH:C027576	158	Chemical	Gene	sensitivity|nmod|START_ENTITY sensitivity|nmod|END_ENTITY	Succinylpurinemic autism : increased sensitivity of defective adenylosuccinate_lyase towards 4-hydroxy-2-nonenal .
10873624	0	4-hydroxy-2-nonenal	0,19	cyclooxygenase-2	85,101	4-hydroxy-2-nonenal	cyclooxygenase-2	MESH:C027576	29527(Tax:10116)	Chemical	Gene	inducer|nsubj|START_ENTITY inducer|nmod|expression expression|amod|END_ENTITY	4-hydroxy-2-nonenal , the end product of lipid peroxidation , is a specific inducer of cyclooxygenase-2 gene expression .
14981143	0	4-hydroxy-2-nonenal	11,30	cyclooxygenase-2	69,85	4-hydroxy-2-nonenal	cyclooxygenase-2	MESH:C027576	5743	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of 4-hydroxy-2-nonenal , a marker of oxidative stress , on the cyclooxygenase-2 of human placenta in chorioamnionitis .
15355999	0	4-hydroxy-2-nonenal	70,89	cyclooxygenase-2	116,132	4-hydroxy-2-nonenal	cyclooxygenase-2	MESH:C027576	5743	Chemical	Gene	START_ENTITY|nmod|inducer inducer|nmod|END_ENTITY	A lipid peroxidation-derived inflammatory mediator : identification of 4-hydroxy-2-nonenal as a potential inducer of cyclooxygenase-2 in macrophages .
17581812	0	4-hydroxy-2-nonenal	104,123	cyclooxygenase-2	51,67	4-hydroxy-2-nonenal	cyclooxygenase-2	MESH:C027576	5743	Chemical	Gene	regulates|advcl|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Identification of a serum component that regulates cyclooxygenase-2 gene expression in cooperation with 4-hydroxy-2-nonenal .
21212636	0	4-hydroxy-2-nonenal	11,30	cyclooxygenase-2	105,121	4-hydroxy-2-nonenal	cyclooxygenase-2	MESH:C027576	5743	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|amod|END_ENTITY	Effects of 4-hydroxy-2-nonenal , a major lipid peroxidation-derived aldehyde , and N-acetylcysteine on the cyclooxygenase-2 expression in human uterine myometrium .
12693935	0	4-hydroxy-2-nonenal	69,88	myoglobin	41,50	4-hydroxy-2-nonenal	myoglobin	MESH:C027576	280695(Tax:9913)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of redox instability of bovine myoglobin by adduction with 4-hydroxy-2-nonenal .
17632137	0	4-hydroxy-2-nonenal	11,30	p53	99,102	4-hydroxy-2-nonenal	p53	MESH:C027576	7157	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|protein protein|compound|END_ENTITY	Effects of 4-hydroxy-2-nonenal , a marker of oxidative stress , on spermatogenesis and expression of p53 protein in male_infertility .
17035013	0	4-hydroxy-3-methoxybenzyl	16,41	TRPV1	51,56	4-hydroxy-3-methoxybenzyl	TRPV1	null	7442	Chemical	Gene	agonists|amod|START_ENTITY agonists|compound|END_ENTITY	Halogenation of 4-hydroxy-3-methoxybenzyl thiourea TRPV1 agonists showed enhanced antagonism to capsaicin .
9920792	0	4-hydroxy-phenyl-retinamide	102,129	tissue_transglutaminase	148,171	4-hydroxy-phenyl-retinamide	tissue transglutaminase	MESH:D017313	7052	Chemical	Gene	START_ENTITY|dep|correlation correlation|nmod|END_ENTITY	Carcinoma cell lines resistant for growth inhibition and apoptosis to retinoic_acid are responsive to 4-hydroxy-phenyl-retinamide : correlation with tissue_transglutaminase .
8027933	0	4-hydroxyamesergide	87,106	5-HT2-receptor	12,26	4-hydroxyamesergide	5-HT2-receptor	MESH:C088215	3356	Chemical	Gene	START_ENTITY|nsubj|activity activity|amod|END_ENTITY	Comparative 5-HT2-receptor antagonist activity of amesergide and its active metabolite 4-hydroxyamesergide in rats and rabbits .
11028555	0	4-hydroxyandrostenedione	25,49	aromatase	4,13	4-hydroxyandrostenedione	aromatase	MESH:C014594	25147(Tax:10116)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	The aromatase inhibitor , 4-hydroxyandrostenedione , restores immune responses following trauma-hemorrhage in males and decreases mortality from subsequent sepsis .
3148922	0	4-hydroxyanisole	35,51	tyrosinase	74,84	4-hydroxyanisole	tyrosinase	MESH:C009760	7299	Chemical	Gene	oxidation|amod|START_ENTITY oxidation|nmod|END_ENTITY	Major primary cytotoxic product of 4-hydroxyanisole oxidation by mushroom tyrosinase is 4-methoxy_ortho_benzoquinone .
15147892	0	4-hydroxyhexenal	34,50	NF-kappaB	0,9	4-hydroxyhexenal	NF-kappaB	MESH:C063409	4790	Chemical	Gene	mechanism|nmod|START_ENTITY mechanism|amod|END_ENTITY	NF-kappaB activation mechanism of 4-hydroxyhexenal via NIK/IKK and p38 MAPK pathway .
22580126	0	4-hydroxynonenal	45,61	Akt1	96,100	4-hydroxynonenal	Akt1	MESH:C027576	207	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Inhibition of hydrogen_peroxide signaling by 4-hydroxynonenal due to differential regulation of Akt1 and Akt2 contributes to decreases in cell survival and proliferation in hepatocellular_carcinoma cells .
15713435	0	4-hydroxynonenal	73,89	CYP2E1	30,36	4-hydroxynonenal	CYP2E1	MESH:C027576	25086(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY effect|dep|role effect|nmod|END_ENTITY	The effect of ethanol-induced CYP2E1 on proteasome activity : the role of 4-hydroxynonenal .
12361807	0	4-hydroxynonenal	0,16	JNK	59,62	4-hydroxynonenal	JNK	MESH:C027576	5599	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	4-hydroxynonenal induces glutamate_cysteine ligase through JNK in HBE1 cells .
23766854	0	4-hydroxynonenal	9,25	KEAP1	40,45	4-hydroxynonenal	KEAP1	MESH:C027576	9817	Chemical	Gene	resistance|amod|START_ENTITY resistance|nmod|END_ENTITY	Enhanced 4-hydroxynonenal resistance in KEAP1 silenced human colon_cancer cells .
11522795	0	4-hydroxynonenal	40,56	RLIP76	78,84	4-hydroxynonenal	RLIP76	MESH:C027576	10928	Chemical	Gene	START_ENTITY|nmod|induction induction|nmod|END_ENTITY	Accelerated metabolism and exclusion of 4-hydroxynonenal through induction of RLIP76 and hGST5 .8 is an early adaptive response of cells to heat and oxidative stress .
12422239	0	4-hydroxynonenal	158,174	RLIP76	68,74	4-hydroxynonenal	RLIP76	MESH:C027576	10928	Chemical	Gene	protein|nmod|START_ENTITY protein|appos|END_ENTITY	Functional reconstitution of Ral-binding GTPase activating protein , RLIP76 , in proteoliposomes catalyzing ATP-dependent transport of glutathione conjugate of 4-hydroxynonenal .
18276794	0	4-hydroxynonenal	20,36	SHP-1	0,5	4-hydroxynonenal	SHP-1	MESH:C027576	5777	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	SHP-1 inhibition by 4-hydroxynonenal activates Jun_N-terminal_kinase and glutamate_cysteine ligase .
18586243	0	4-hydroxynonenal	125,141	Toll-like_receptor-4	0,20	4-hydroxynonenal	Toll-like receptor-4	MESH:C027576	7099	Chemical	Gene	mediates|xcomp|START_ENTITY mediates|nsubj|END_ENTITY	Toll-like_receptor-4 mediates neuronal apoptosis induced by amyloid beta-peptide and the membrane lipid peroxidation product 4-hydroxynonenal .
8878557	0	4-hydroxynonenal	0,16	c-myb	39,44	4-hydroxynonenal	c-myb	MESH:C027576	4602	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	4-hydroxynonenal specifically inhibits c-myb but does not affect c-fos expressions in HL-60 cells .
3475758	0	4-hydroxynonenal	10,26	c-myc	30,35	4-hydroxynonenal	c-myc	MESH:C027576	4609	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of 4-hydroxynonenal on c-myc expression .
8074703	0	4-hydroxynonenal	42,58	c-myc	14,19	4-hydroxynonenal	c-myc	MESH:C027576	4609	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Inhibition Inhibition|nmod|expression expression|amod|END_ENTITY	Inhibition of c-myc expression induced by 4-hydroxynonenal , a product of lipid peroxidation , in the HL-60 human leukemic cell line .
12386159	0	4-hydroxynonenal	66,82	epithelial_fatty_acid-binding_protein	25,62	4-hydroxynonenal	epithelial fatty acid-binding protein	MESH:C027576	140868(Tax:10116)	Chemical	Gene	modification|nmod|START_ENTITY modification|nmod|END_ENTITY	Covalent modification of epithelial_fatty_acid-binding_protein by 4-hydroxynonenal in vitro and in vivo .
16631518	0	4-hydroxynonenal	44,60	gamma-Glutamyl_transpeptidase	0,29	4-hydroxynonenal	gamma-Glutamyl transpeptidase	MESH:C027576	116568(Tax:10116)	Chemical	Gene	cells|amod|START_ENTITY induced|nmod|cells induced|nsubjpass|END_ENTITY	gamma-Glutamyl_transpeptidase is induced by 4-hydroxynonenal via EpRE/Nrf2 signaling in rat epithelial type II cells .
21401344	0	4-hydroxynonenal	46,62	glutathione_transferases	16,40	4-hydroxynonenal	glutathione transferases	MESH:C027576	373156	Chemical	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of glutathione_transferases with 4-hydroxynonenal .
12065730	0	4-hydroxynonenal	0,16	interleukin-6	27,40	4-hydroxynonenal	interleukin-6	MESH:C027576	24498(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|amod|END_ENTITY	4-hydroxynonenal decreases interleukin-6 expression and protein production in primary rat Kupffer cells by inhibiting nuclear factor-kappaB activation .
18620056	0	4-hydroxyphenyl_ketones	95,118	17beta-hydroxysteroid_dehydrogenase	170,205	4-hydroxyphenyl ketones	17beta-hydroxysteroid dehydrogenase	null	51478	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Synthesis , biochemical evaluation and rationalisation of the inhibitory activity of a range of 4-hydroxyphenyl_ketones as potent and specific inhibitors of the type 3 of 17beta-hydroxysteroid_dehydrogenase -LRB- 17beta-HSD3 -RRB- .
16300947	0	4-hydroxyphenyl_sulfonamides	12,40	estrogen_receptor	62,79	4-hydroxyphenyl sulfonamides	estrogen receptor	null	2099	Chemical	Gene	START_ENTITY|nmod|ligands ligands|compound|END_ENTITY	Substituted 4-hydroxyphenyl_sulfonamides as pathway-selective estrogen_receptor ligands .
20170512	0	4-hydroxytamoxifen	74,92	p27	41,44	4-hydroxytamoxifen	p27	MESH:C016601	10671	Chemical	Gene	effects|nmod|START_ENTITY expression|dep|effects expression|amod|END_ENTITY	Upstream molecular signaling pathways of p27 -LRB- Kip1 -RRB- expression : effects of 4-hydroxytamoxifen , dexamethasone , and retinoic_acids .
9667651	0	4-hydroxytamoxifen	29,47	transforming_growth_factor_alpha	64,96	4-hydroxytamoxifen	transforming growth factor alpha	MESH:C016601	7124	Chemical	Gene	START_ENTITY|nmod|induction induction|nmod|mRNA mRNA|compound|END_ENTITY	The oestrogen-like effect of 4-hydroxytamoxifen on induction of transforming_growth_factor_alpha mRNA in MDA-MB-231_breast_cancer cells stably expressing the oestrogen receptor .
2066989	0	4-hydroxythiazole	0,17	5-lipoxygenase	32,46	4-hydroxythiazole	5-lipoxygenase	null	240	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	4-hydroxythiazole inhibitors of 5-lipoxygenase .
14673714	0	4-iodopyrazole	129,143	NP4	171,174	4-iodopyrazole	NP4	MESH:C010201	5657	Chemical	Gene	complexes|amod|START_ENTITY complexes|nmod|END_ENTITY	Axial ligand complexes of the Rhodnius nitrophorins : reduction potentials , binding constants , EPR spectra , and structures of the 4-iodopyrazole and imidazole complexes of NP4 .
27092941	0	4-ipomeanol	65,76	CYP4B1	16,22	4-ipomeanol	CYP4B1	MESH:C001470	1580	Chemical	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	Optimized human CYP4B1 in combination with the alkylator prodrug 4-ipomeanol serves as a novel suicide gene system for adoptive T-cell therapies .
12765243	0	4-methylbenzylidene-camphor	52,79	estrogen_receptor_alpha	14,37	4-methylbenzylidene-camphor	estrogen receptor alpha	MESH:C038939	2099	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of estrogen_receptor_alpha and ERbeta by 4-methylbenzylidene-camphor in human and rat cells : comparison with phyto - and xenoestrogens .
10553951	0	4-methylcatechol	128,144	brain-derived_neurotrophic_factor	38,71	4-methylcatechol	brain-derived neurotrophic factor	MESH:C018599	627	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of a physiologically active brain-derived_neurotrophic_factor in the infant rat brain by peripheral administration of 4-methylcatechol .
24784139	0	4-methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic_acid	0,58	fatty-acid_synthase	82,101	4-methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid	fatty-acid synthase	null	2194	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	4-methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic_acid -LRB- C75 -RRB- , an inhibitor of fatty-acid_synthase , suppresses the mitochondrial fatty_acid synthesis pathway and impairs mitochondrial function .
19730755	0	4-methylimidazole	11,28	glutamate_decarboxylase	41,64	4-methylimidazole	glutamate decarboxylase	MESH:C023439	14645(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Effects of 4-methylimidazole on cerebral glutamate_decarboxylase activity and specific GABA receptor binding in mice .
3615351	0	4-methylphenol	29,43	cytochrome_P-450	86,102	4-methylphenol	cytochrome P-450	MESH:C032538	4051	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Spectral interaction between 4-methylphenol and beta-oestradiol on hepatic microsomal cytochrome_P-450 : difference between ethanol and phenobarbital pretreatment .
17470403	0	4-methylumbelliferone	45,66	matrix_metalloproteinase-9	15,41	4-methylumbelliferone	matrix metalloproteinase-9	MESH:C489431	4318	Chemical	Gene	Suppression|nmod|START_ENTITY Suppression|nmod|END_ENTITY	Suppression of matrix_metalloproteinase-9 by 4-methylumbelliferone .
2965573	0	4-methylumbelliferyl_beta-N-acetylglucosaminide_6-sulphate	78,136	beta-N-acetylhexosaminidase	28,55	4-methylumbelliferyl beta-N-acetylglucosaminide 6-sulphate	beta-N-acetylhexosaminidase	null	10724	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Intermediate forms of human beta-N-acetylhexosaminidase lack activity towards 4-methylumbelliferyl_beta-N-acetylglucosaminide_6-sulphate .
16327152	0	4-n-butylresorcinol	22,41	tyrosinase	45,55	4-n-butylresorcinol	tyrosinase	MESH:C508220	22173(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activity activity|amod|END_ENTITY	Inhibitory effects of 4-n-butylresorcinol on tyrosinase activity and melanin synthesis .
8267647	0	4-nitrophenol	14,27	CYP2E1	75,81	4-nitrophenol	CYP2E1	MESH:C024836	1571	Chemical	Gene	START_ENTITY|nmod|probe probe|nmod|END_ENTITY	Validation of 4-nitrophenol as an in vitro substrate probe for human liver CYP2E1 using cDNA expression and microsomal kinetic techniques .
12969784	0	4-nitroquinoline_1-oxide	185,209	cyclooxygenase-2	32,48	4-nitroquinoline 1-oxide	cyclooxygenase-2	MESH:D015112	29527(Tax:10116)	Chemical	Gene	initiated|advcl|START_ENTITY effects|acl|initiated effects|nmod|inhibitors inhibitors|amod|END_ENTITY	Inhibitory effects of selective cyclooxygenase-2 inhibitors , nimesulide and etodolac , on the development of squamous_cell_dysplasias_and_carcinomas of the tongue in rats initiated with 4-nitroquinoline_1-oxide .
17374970	0	4-nitroquinoline_1-oxide	95,119	cyclooxygenase-2	146,162	4-nitroquinoline 1-oxide	cyclooxygenase-2	MESH:D015112	29527(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|amod|END_ENTITY	Expression of receptor for advanced glycation end products during rat tongue carcinogenesis by 4-nitroquinoline_1-oxide and effect of a selective cyclooxygenase-2 inhibitor , etodolac .
20213142	0	4-nitroquinoline_1-oxide	90,114	matrix_metalloproteinases_2_and_9	12,45	4-nitroquinoline 1-oxide	matrix metalloproteinases 2 and 9	MESH:D015112	81686(Tax:10116)	Chemical	Gene	induced|advcl|START_ENTITY induced|nsubj|role role|nmod|END_ENTITY	The role of matrix_metalloproteinases_2_and_9 during rat tongue carcinogenesis induced by 4-nitroquinoline_1-oxide .
12061770	0	4-nonylphenol	93,106	inducible_nitric_oxide_synthase	15,46	4-nonylphenol	inducible nitric oxide synthase	MESH:C041594	18126(Tax:10090)	Chemical	Gene	Suppression|nmod|START_ENTITY Suppression|nmod|expression expression|compound|END_ENTITY	Suppression of inducible_nitric_oxide_synthase and tumor_necrosis_factor-alpha expression by 4-nonylphenol in macrophages .
20545486	0	4-oxo-b-lactam	95,109	leukocyte_elastase	129,147	4-oxo-b-lactam	leukocyte elastase	null	1991	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|nmod|END_ENTITY	Synthesis , stability , biochemical and pharmacokinetic properties of a new potent and selective 4-oxo-b-lactam inhibitor of human leukocyte_elastase .
19020473	0	4-oxoquinoline-3-carboxylic_acid	28,60	VIII	67,71	4-oxoquinoline-3-carboxylic acid	VIII	null	1351	Chemical	Gene	-RSB-|amod|START_ENTITY -RSB-|compound|END_ENTITY	Heterocycles -LSB- h -RSB- - fused onto 4-oxoquinoline-3-carboxylic_acid , part VIII -LSB- 1 -RSB- .
23232060	0	4-phenyl-2-phenylaminopyridine	13,43	TNIK	50,54	4-phenyl-2-phenylaminopyridine	TNIK	null	23043	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Discovery of 4-phenyl-2-phenylaminopyridine based TNIK inhibitors .
17905586	0	4-phenylamino-3-quinolinecarbonitrile	26,63	Src	64,67	4-phenylamino-3-quinolinecarbonitrile	Src	null	6714	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Facile preparation of new 4-phenylamino-3-quinolinecarbonitrile Src kinase inhibitors via 7-fluoro intermediates : identification of potent 7-amino analogs .
11689083	0	4-phenylamino-3-quinolinecarbonitriles	16,54	Src	79,82	4-phenylamino-3-quinolinecarbonitriles	Src	null	20779(Tax:10090)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Optimization of 4-phenylamino-3-quinolinecarbonitriles as potent inhibitors of Src kinase activity .
23676312	0	4-phenylbutylate	34,50	serotonin_transporter	74,95	4-phenylbutylate	serotonin transporter	null	6532	Chemical	Gene	START_ENTITY|nmod|function function|nmod|END_ENTITY	Effects of the chemical chaperone 4-phenylbutylate on the function of the serotonin_transporter -LRB- SERT -RRB- expressed in COS-7 cells .
15138583	0	4-phenylbutyrate	30,46	GAPDH	58,63	4-phenylbutyrate	GAPDH	MESH:C075773	2597	Chemical	Gene	suppresses|amod|START_ENTITY END_ENTITY|nsubj|suppresses	Histone deacetylase inhibitor 4-phenylbutyrate suppresses GAPDH mRNA expression in glioma cells .
12417726	0	4-phenylbutyrate	67,83	PEX11alpha	0,10	4-phenylbutyrate	PEX11alpha	MESH:C075773	18631(Tax:10090)	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	PEX11alpha is required for peroxisome proliferation in response to 4-phenylbutyrate but is dispensable for peroxisome_proliferator-activated_receptor_alpha-mediated peroxisome proliferation .
15093585	0	4-phenylbutyrate	30,46	glial_fibrillary_acidic_protein	57,88	4-phenylbutyrate	glial fibrillary acidic protein	MESH:C075773	2670	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Histone deacetylase inhibitor 4-phenylbutyrate modulates glial_fibrillary_acidic_protein and connexin_43 expression , and enhances gap-junction communication , in human glioblastoma cells .
24027526	0	4-phenylbutyrate	49,65	histone_deacetylase	19,38	4-phenylbutyrate	histone deacetylase	MESH:C075773	9734	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|effects effects|nmod|END_ENTITY	The effects of the histone_deacetylase inhibitor 4-phenylbutyrate on gap junction conductance and permeability .
19763542	0	4-pyridine_aldoxime	11,30	acetylcholinesterase	56,76	4-pyridine aldoxime	acetylcholinesterase	null	100422792	Chemical	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Effects of 4-pyridine_aldoxime on nerve agent-inhibited acetylcholinesterase activity in guinea_pigs .
16647258	0	4-pyrone	55,63	COX-2	64,69	4-pyrone	COX-2	CHEBI:37966	26198(Tax:10116)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Racemic and chiral sulfoxides as potential prodrugs of 4-pyrone COX-2 inhibitors .
26928712	0	4-quinolone	45,56	acetylcholinesterase	64,84	4-quinolone	acetylcholinesterase	null	43	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effects of novel acylhydrazones derived from 4-quinolone on the acetylcholinesterase activity and Ab42 peptide fibrils formation .
3997884	0	4-steroid	31,40	5_alpha-reductase	41,58	4-steroid	5 alpha-reductase	null	6715	Chemical	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Modulation of epididymal delta 4-steroid 5_alpha-reductase activity in vitro by the phospholipid environment .
17428657	0	4-substituted_phenyl_cyclohexanes	43,76	bradykinin_B1_receptor	7,29	4-substituted phenyl cyclohexanes	bradykinin B1 receptor	null	623	Chemical	Gene	antagonists|dep|START_ENTITY antagonists|amod|END_ENTITY	Potent bradykinin_B1_receptor antagonists : 4-substituted_phenyl_cyclohexanes .
25759032	0	4-substituted_piperazine	51,75	5-HT1A	91,97	4-substituted piperazine	5-HT1A	null	3350	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Synthesis and binding properties of new long-chain 4-substituted_piperazine derivatives as 5-HT1A and 5-HT7 receptor ligands .
6357100	0	4-substituted_pyrazoles	80,103	alcohol_dehydrogenase	18,39	4-substituted pyrazoles	alcohol dehydrogenase	null	10327	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	The inhibition of alcohol_dehydrogenase in vitro and in isolated hepatocytes by 4-substituted_pyrazoles .
23578311	0	4-tert-butylphenol	53,71	tyrosinase	25,35	4-tert-butylphenol	tyrosinase	MESH:C006862	7299	Chemical	Gene	inactivation|nmod|START_ENTITY inactivation|nmod|END_ENTITY	Indirect inactivation of tyrosinase in its action on 4-tert-butylphenol .
8020482	0	4-tert-butylphenol	35,53	tyrosinase	57,67	4-tert-butylphenol	tyrosinase	MESH:C006862	7299	Chemical	Gene	oxidation|nmod|START_ENTITY study|nmod|oxidation study|nmod|END_ENTITY	Kinetics study of the oxidation of 4-tert-butylphenol by tyrosinase .
25324873	0	4-tert-octylphenol	19,37	oxytocin	59,67	4-tert-octylphenol	oxytocin	MESH:C105260	5020	Chemical	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	Adverse effects of 4-tert-octylphenol on the production of oxytocin and hCG in pregnant rats .
10454291	0	4-tertiary_butylphenol	11,33	tyrosinase	41,51	4-tertiary butylphenol	tyrosinase	MESH:C006862	7299	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|amod|END_ENTITY	Effects of 4-tertiary_butylphenol on the tyrosinase activity in human melanocytes .
16428448	0	4-vinyl_cyclohexene_diepoxide	39,68	Nrf2	72,76	4-vinyl cyclohexene diepoxide	Nrf2	MESH:C012606	18024(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Accelerated ovarian_failure induced by 4-vinyl_cyclohexene_diepoxide in Nrf2 null mice .
2836617	0	44-amino-acid	60,73	SH	74,76	44-amino-acid	SH	null	3160797(Tax:11207)	Chemical	Gene	protein|amod|START_ENTITY protein|compound|END_ENTITY	Cell surface expression and orientation in membranes of the 44-amino-acid SH protein of simian_virus_5 .
11401391	0	4E-BP	23,28	eIF4E	0,5	4E-BP	eIF4E	null	1977	Chemical	Gene	association|nmod|START_ENTITY association|amod|END_ENTITY	eIF4E association with 4E-BP decreases rapidly following fertilization in sea urchin .
3588410	0	4MA	14,17	5_alpha-reductase	41,58	4MA	5 alpha-reductase	null	6715	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|inhibitor inhibitor|nmod|END_ENTITY	The effect of 4MA , a potent inhibitor of 5_alpha-reductase , on the growth of androgen-responsive_human_genitourinary_tumors grown in athymic nude_mice .
20310011	0	4SC-101	0,7	IL-17	50,55	4SC-101	IL-17	MESH:C553728	16171(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	4SC-101 , a novel immunosuppressive drug , inhibits IL-17 and attenuates_colitis in two murine models of inflammatory_bowel_disease .
20413687	0	4SC-101	0,7	dihydroorotate_dehydrogenase	32,60	4SC-101	dihydroorotate dehydrogenase	MESH:C553728	56749(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	4SC-101 , a novel small molecule dihydroorotate_dehydrogenase inhibitor , suppresses systemic_lupus erythematosus in MRL - -LRB- Fas -RRB- lpr mice .
26119961	0	4b-hydroxycholesterol	0,21	CYP3A	39,44	4b-hydroxycholesterol	CYP3A	null	1576	Chemical	Gene	START_ENTITY|nmod|marker marker|compound|END_ENTITY	4b-hydroxycholesterol as an endogenous CYP3A marker in cancer patients treated with taxanes .
19954708	0	4beta-hydroxycholesterol	0,24	CYP3A4	40,46	4beta-hydroxycholesterol	CYP3A4	MESH:C099828	1576	Chemical	Gene	START_ENTITY|nmod|marker marker|nmod|END_ENTITY	4beta-hydroxycholesterol as a marker of CYP3A4 inhibition in vivo - effects of itraconazole in man .
12028998	0	5,10-Methylenetetrahydrofolate	0,30	MTHFR	42,47	5,10-Methylenetetrahydrofolate	MTHFR	MESH:C013123	4524	Chemical	Gene	reductase|amod|START_ENTITY reductase|appos|END_ENTITY	5,10-Methylenetetrahydrofolate _ reductase -LRB- MTHFR -RRB- assay in the forward direction : residual activity in MTHFR_deficiency .
19178944	0	5,10-Methylenetetrahydrofolate	0,30	MTHFR	42,47	5,10-Methylenetetrahydrofolate	MTHFR	MESH:C013123	4524	Chemical	Gene	reductase|amod|START_ENTITY reduce|nsubj|reductase reduce|dep|END_ENTITY	5,10-Methylenetetrahydrofolate reductase -LRB- MTHFR -RRB- low activity genotypes reduce the risk of relapse-related acute_lymphoblastic_leukemia -LRB- ALL -RRB- .
23959833	0	5,10-Methylenetetrahydrofolate	0,30	MTHFR	42,47	5,10-Methylenetetrahydrofolate	MTHFR	MESH:C013123	4524	Chemical	Gene	reductase|amod|START_ENTITY reductase|appos|END_ENTITY	5,10-Methylenetetrahydrofolate reductase -LRB- MTHFR -RRB- , methionine_synthase -LRB- MTRR -RRB- , and methionine_synthase reductase -LRB- MTR -RRB- gene polymorphisms and adult_meningioma risk .
24277487	0	5,10-Methylenetetrahydrofolate	0,30	MTHFR	42,47	5,10-Methylenetetrahydrofolate	MTHFR	MESH:C013123	4524	Chemical	Gene	_|amod|START_ENTITY C677T|amod|_ C677T|appos|END_ENTITY	5,10-Methylenetetrahydrofolate _ reductase -LRB- MTHFR -RRB- C677T and A1298C polymorphisms : genotype frequency and association with homocysteine and folate levels in middle-southern Italian adults .
11558898	0	5,10-methylenetetrahydrofolate	18,48	MTHFR	60,65	5,10-methylenetetrahydrofolate	MTHFR	MESH:C013123	4524	Chemical	Gene	_|amod|START_ENTITY association|nmod|_ reductase|nsubj|association reductase|xcomp|polymorphism polymorphism|dep|END_ENTITY	An association of 5,10-methylenetetrahydrofolate _ reductase -LRB- MTHFR -RRB- gene polymorphism and common carotid_atherosclerosis .
12033523	0	5,10-methylenetetrahydrofolate	139,169	MTHFR	192,197	5,10-methylenetetrahydrofolate	MTHFR	MESH:C013123	4524	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Are the associations between life-style related factors and plasma total homocysteine concentration different according to polymorphism of 5,10-methylenetetrahydrofolate reductase gene -LRB- C677T MTHFR -RRB- ?
12180076	0	5,10-methylenetetrahydrofolate	28,58	MTHFR	70,75	5,10-methylenetetrahydrofolate	MTHFR	MESH:C013123	4524	Chemical	Gene	mutations|amod|START_ENTITY mutations|appos|END_ENTITY	Does prenatal screening for 5,10-methylenetetrahydrofolate _ reductase -LRB- MTHFR -RRB- mutations in high-risk neural tube defect pregnancies make sense ?
15548731	0	5,10-methylenetetrahydrofolate	15,45	MTHFR	57,62	5,10-methylenetetrahydrofolate	MTHFR	MESH:C013123	17769(Tax:10090)	Chemical	Gene	reductase|amod|START_ENTITY reductase|appos|END_ENTITY	Infertility in 5,10-methylenetetrahydrofolate _ reductase -LRB- MTHFR -RRB- - deficient male mice is partially alleviated by lifetime dietary betaine supplementation .
16533336	0	5,10-methylenetetrahydrofolate	45,75	MTHFR	87,92	5,10-methylenetetrahydrofolate	MTHFR	MESH:C013123	4524	Chemical	Gene	reductase|amod|START_ENTITY gene|amod|reductase gene|appos|END_ENTITY	Effects of the common 677C > T mutation of the 5,10-methylenetetrahydrofolate reductase -LRB- MTHFR -RRB- gene on ovarian responsiveness to recombinant follicle-stimulating hormone .
17201138	0	5,10-methylenetetrahydrofolate	17,47	MTHFR	59,64	5,10-methylenetetrahydrofolate	MTHFR	MESH:C013123	4524	Chemical	Gene	reductase|amod|START_ENTITY reductase|appos|C677T C677T|compound|END_ENTITY	Polymorphisms of 5,10-methylenetetrahydrofolate _ reductase -LRB- MTHFR C677T -RRB- and thymidylate_synthase enhancer region -LRB- TSER -RRB- as a risk factor of cholangiocarcinoma in a Korean population .
17203359	0	5,10-methylenetetrahydrofolate	20,50	MTHFR	62,67	5,10-methylenetetrahydrofolate	MTHFR	MESH:C013123	4524	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Do polymorphisms of 5,10-methylenetetrahydrofolate reductase -LRB- MTHFR -RRB- gene affect the risk of childhood acute_lymphoblastic_leukemia ?
17904003	0	5,10-methylenetetrahydrofolate	18,48	MTHFR	60,65	5,10-methylenetetrahydrofolate	MTHFR	MESH:C013123	4524	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	An association of 5,10-methylenetetrahydrofolate _ reductase -LRB- MTHFR -RRB- gene polymorphism and ischemic_stroke .
17970089	0	5,10-methylenetetrahydrofolate	19,49	MTHFR	61,66	5,10-methylenetetrahydrofolate	MTHFR	MESH:C013123	4524	Chemical	Gene	reductase|amod|START_ENTITY reductase|dep|C677T C677T|compound|END_ENTITY	Association of the 5,10-methylenetetrahydrofolate _ reductase -LRB- MTHFR C677T and A1298C -RRB- polymorphisms in Korean patients with adult acute_lymphoblastic_leukemia .
18421714	0	5,10-methylenetetrahydrofolate	0,30	MTHFR	42,47	5,10-methylenetetrahydrofolate	MTHFR	MESH:C013123	4524	Chemical	Gene	reductase|amod|START_ENTITY reductase|appos|END_ENTITY	5,10-methylenetetrahydrofolate _ reductase -LRB- MTHFR -RRB- polymorphisms and the risk of acute_lymphoblastic_leukemia -LRB- ALL -RRB- in Filipino children .
19063701	0	5,10-methylenetetrahydrofolate	34,64	MTHFR	76,81	5,10-methylenetetrahydrofolate	MTHFR	MESH:C013123	4524	Chemical	Gene	reductase|amod|START_ENTITY reductase|appos|END_ENTITY	Serum total homocysteine , folate , 5,10-methylenetetrahydrofolate _ reductase -LRB- MTHFR -RRB- 677C -- > T genotype and subclinical atherosclerosis .
19943541	0	5,10-methylenetetrahydrofolate	44,74	MTHFR	86,91	5,10-methylenetetrahydrofolate	MTHFR	MESH:C013123	4524	Chemical	Gene	reductase|amod|START_ENTITY reductase|appos|END_ENTITY	-LSB- Genetic conditioned changes in activity of 5,10-methylenetetrahydrofolate reductase -LRB- MTHFR -RRB- and recurrent miscarriages -RSB- .
20580032	0	5,10-methylenetetrahydrofolate	85,115	MTHFR	127,132	5,10-methylenetetrahydrofolate	MTHFR	MESH:C013123	4524	Chemical	Gene	reductase|amod|START_ENTITY reductase|appos|END_ENTITY	Serum adiponectin is associated with homocysteine in elderly men and women , and with 5,10-methylenetetrahydrofolate reductase -LRB- MTHFR -RRB- in a sex-dependent manner .
21481373	0	5,10-methylenetetrahydrofolate	48,78	MTHFR	90,95	5,10-methylenetetrahydrofolate	MTHFR	MESH:C013123	4524	Chemical	Gene	reductase|amod|START_ENTITY gene|amod|reductase gene|appos|END_ENTITY	Divergent effects of the 677C > T mutation of the 5,10-methylenetetrahydrofolate reductase -LRB- MTHFR -RRB- gene on ovarian responsiveness and anti-M llerian hormone concentrations .
22023786	0	5,10-methylenetetrahydrofolate	26,56	MTHFR	68,73	5,10-methylenetetrahydrofolate	MTHFR	MESH:C013123	4524	Chemical	Gene	reductase|amod|START_ENTITY reductase|appos|END_ENTITY	Haplotype analysis of the 5,10-methylenetetrahydrofolate reductase -LRB- MTHFR -RRB- c. 1298A > C -LRB- E429A -RRB- polymorphism .
22762524	0	5,10-methylenetetrahydrofolate	46,76	MTHFR	88,93	5,10-methylenetetrahydrofolate	MTHFR	MESH:C013123	4524	Chemical	Gene	reductase|amod|START_ENTITY prevalence|nmod|reductase prevalence|appos|END_ENTITY	Genotype prevalence and allele frequencies of 5,10-methylenetetrahydrofolate reductase -LRB- MTHFR -RRB- C677T mutation in two caste groups of India .
23105344	0	5,10-methylenetetrahydrofolate	28,58	MTHFR	70,75	5,10-methylenetetrahydrofolate	MTHFR	MESH:C013123	4524	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphism -LRB- C677T -RRB- in the 5,10-methylenetetrahydrofolate reductase -LRB- MTHFR -RRB- gene : A preliminary study on north Indian men .
23227261	0	5,10-methylenetetrahydrofolate	23,53	MTHFR	65,70	5,10-methylenetetrahydrofolate	MTHFR	MESH:C013123	4524	Chemical	Gene	reductase|amod|START_ENTITY reductase|appos|END_ENTITY	Folate metabolism gene 5,10-methylenetetrahydrofolate reductase -LRB- MTHFR -RRB- is associated with ADHD in myelomeningocele patients .
9133512	0	5,10-methylenetetrahydrofolate	24,54	MTHFR	66,71	5,10-methylenetetrahydrofolate	MTHFR	MESH:C013123	4524	Chemical	Gene	reductase|amod|START_ENTITY polymorphism|nmod|reductase polymorphism|appos|END_ENTITY	Genetic polymorphism of 5,10-methylenetetrahydrofolate reductase -LRB- MTHFR -RRB- as a risk factor for coronary_artery_disease .
9562260	0	5,10-methylenetetrahydrofolate	26,56	MTHFR	68,73	5,10-methylenetetrahydrofolate	MTHFR	MESH:C013123	4524	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	677C to T mutation in the 5,10-methylenetetrahydrofolate reductase -LRB- MTHFR -RRB- gene and plasma homocyst -LRB- e -RRB- ine levels in patients with TIA or minor_stroke .
9680386	0	5,10-methylenetetrahydrofolate	150,180	MTHFR	71,76	5,10-methylenetetrahydrofolate	MTHFR	MESH:C013123	17769(Tax:10090)	Chemical	Gene	remethylation|amod|START_ENTITY conversion|nmod|remethylation catalyzes|dobj|conversion catalyzes|nsubj|structure structure|nmod|Methylenetetrahydrofolate_reductase Methylenetetrahydrofolate_reductase|appos|END_ENTITY	Gene structure of human and mouse methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- Methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate , a co-substrate for homocysteine remethylation to methionine .
17438654	0	5,10-methylenetetralydrofolate	17,47	MTHFR	59,64	5,10-methylenetetralydrofolate	MTHFR	null	4524	Chemical	Gene	reductase|amod|START_ENTITY reductase|appos|END_ENTITY	Polymorphisms of 5,10-methylenetetralydrofolate reductase -LRB- MTHFR -RRB- , fruit and vegetable intake , and the risk of stomach_cancer .
18378452	0	5,6,7,8-tetrahydroquinoline	34,61	C5a_receptor	62,74	5,6,7,8-tetrahydroquinoline	C5a receptor	MESH:C528846	728	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|amod|END_ENTITY	Synthesis and characterization of 5,6,7,8-tetrahydroquinoline C5a_receptor antagonists .
17693955	0	5,6,7-trihydroxyflavones	22,46	tyrosinase	50,60	5,6,7-trihydroxyflavones	tyrosinase	null	7299	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Inhibitory effects of 5,6,7-trihydroxyflavones on tyrosinase .
4416934	0	5,6-Dihydroxytryptamine	0,23	catechol_O-methyltransferase	43,71	5,6-Dihydroxytryptamine	catechol O-methyltransferase	MESH:D015115	1312	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	5,6-Dihydroxytryptamine is a substrate for catechol_O-methyltransferase .
8504823	1	5,6-dihydropyrimidine	133,154	hydantoinase	112,124	5,6-dihydropyrimidine	hydantoinase	null	1807	Chemical	Gene	activity|amod|START_ENTITY END_ENTITY|nmod|activity	A hydantoinase with no 5,6-dihydropyrimidine amidohydrolase activity .
15661813	0	5,7-Dimethoxyflavone	0,20	CYP1A1	35,41	5,7-Dimethoxyflavone	CYP1A1	MESH:C060298	1543	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	5,7-Dimethoxyflavone downregulates CYP1A1 expression and benzo -LSB- a -RSB- pyrene-induced DNA binding in Hep G2 cells .
6232468	0	5,7-dihydroxytryptamine	15,38	thyrotrophin-releasing_hormone	68,98	5,7-dihydroxytryptamine	thyrotrophin-releasing hormone	MESH:D015116	25569(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of 5,7-dihydroxytryptamine and p-chlorophenylalanine on thyrotrophin-releasing_hormone in regions of the brain and spinal cord of the rat .
3928818	0	5,7-dihydroxytryptamine	17,40	thyrotropin-releasing_hormone	51,80	5,7-dihydroxytryptamine	thyrotropin-releasing hormone	MESH:D015116	25569(Tax:10116)	Chemical	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	Intraventricular 5,7-dihydroxytryptamine increases thyrotropin-releasing_hormone content in regions of rat brain .
2176712	0	5,7-dihydroxytryptamine	78,101	tryptophan_hydroxylase	10,32	5,7-dihydroxytryptamine	tryptophan hydroxylase	MESH:D015116	24848(Tax:10116)	Chemical	Gene	spared|advcl|START_ENTITY spared|nsubj|mRNA mRNA|amod|END_ENTITY	Increased tryptophan_hydroxylase mRNA in raphe serotonergic neurons spared by 5,7-dihydroxytryptamine .
2421731	0	5,7-dihydroxytryptamine	84,107	tryptophan_hydroxylase	10,32	5,7-dihydroxytryptamine	tryptophan hydroxylase	MESH:D015116	24848(Tax:10116)	Chemical	Gene	spared|advcl|START_ENTITY spared|nsubj|activity activity|amod|END_ENTITY	Increased tryptophan_hydroxylase activity in serotonergic nerve terminals spared by 5,7-dihydroxytryptamine .
8508321	0	5,7-dihydroxytryptamine	167,190	tryptophan_hydroxylase	37,59	5,7-dihydroxytryptamine	tryptophan hydroxylase	MESH:D015116	24848(Tax:10116)	Chemical	Gene	Changes|nmod|START_ENTITY Changes|nmod|END_ENTITY	Changes in activity and mRNA for rat tryptophan_hydroxylase and aromatic L-amino_acid decarboxylase of brain serotonergic cell bodies and terminals following neonatal 5,7-dihydroxytryptamine .
8899474	0	5-3_beta-hydroxysteroid	40,63	5_alpha-reductase	92,109	5-3 beta-hydroxysteroid	5 alpha-reductase	null	6715	Chemical	Gene	activities|amod|START_ENTITY activities|amod|END_ENTITY	In vitro inhibition of testicular delta 5-3_beta-hydroxysteroid dehydrogenase and prostatic 5_alpha-reductase activities in rats and humans by strogen forte extract .
24513177	0	5-Aza-2-deoxycytidine	0,21	COUP-TFII	50,59	5-Aza-2-deoxycytidine	COUP-TFII	MESH:C014347	7026	Chemical	Gene	increase|amod|START_ENTITY END_ENTITY|nsubj|increase	5-Aza-2-deoxycytidine and trichostatin_A increase COUP-TFII expression in antiestrogen-resistant breast_cancer cell lines .
19172108	0	5-Aza-CdR	9,18	RASSF1A	50,57	5-Aza-CdR	RASSF1A	null	11186	Chemical	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Study of 5-Aza-CdR on transcription regulation of RASSF1A gene in the BIU87 cell line .
26121857	0	5-Aza-CdR	13,22	RASSF1A	53,60	5-Aza-CdR	RASSF1A	null	11186	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|Gene Gene|compound|END_ENTITY	-LSB- The Role of 5-Aza-CdR on Methylation of Promoter in RASSF1A Gene in Endometrial_Carcinoma -RSB- .
19728916	0	5-Aza-dC	11,19	FHIT	23,27	5-Aza-dC	FHIT	null	2272	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effect of 5-Aza-dC on FHIT gene expression in hepatocellular_carcinoma cell line HepG2 -RSB- .
1346974	0	5-Chlorolevulinate	0,18	porphobilinogen_synthase	35,59	5-Chlorolevulinate	porphobilinogen synthase	null	210	Chemical	Gene	modification|amod|START_ENTITY modification|nmod|END_ENTITY	5-Chlorolevulinate modification of porphobilinogen_synthase identifies a potential role for the catalytic zinc .
15967383	2	5-FU	551,555	CEA	559,562	5-FU	CEA	MESH:D005472	1084	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	In the present study , we examined the in vitro effects of five PKIs , i.e. ST , 1-5-isoquinolinyl-sulfonyl-2-methylpiperazine -LRB- H-7 -RRB- , bisindolylmaleimide-I -LRB- BIS -RRB- , Genistein -LRB- GEN -RRB- , and Herbimycin_A -LRB- HERB -RRB- alone or in combination with 5-FU on CEA expression .
21224565	0	5-FU	44,48	CEA	182,185	5-FU	CEA	MESH:D005472	1084	Chemical	Gene	g|nmod|START_ENTITY Efficacy|dep|g hepatic|nsubj|Efficacy hepatic|nmod|ng/mL ng/mL|nmod|END_ENTITY	-LSB- Efficacy of short-term high volume -LRB- 6 g of 5-FU in a week -RRB- hepatic arterial infusion for synchronous diffuse liver metastases of sigmoid colon_cancer with over 40 thousand ng/mL of CEA of ascites -RSB- .
21541578	0	5-FU	78,82	CEA	32,35	5-FU	CEA	MESH:D005472	1084	Chemical	Gene	chemotherapy|nummod|START_ENTITY correlates|nmod|chemotherapy correlates|nsubj|carcinoembryonic_antigen carcinoembryonic_antigen|appos|END_ENTITY	Serum carcinoembryonic_antigen -LRB- CEA -RRB- correlates with the survival time during 5-FU hepatic arterial infusion chemotherapy for unresectable colorectal hepatic metastases .
18931571	0	5-FU	40,44	CPT-11	18,24	5-FU	CPT-11	MESH:D005472	963084(Tax:115711)	Chemical	Gene	therapy|amod|START_ENTITY therapy|amod|END_ENTITY	-LSB- Phase I study of CPT-11 and continuous 5-FU / l-leucovorin combination therapy -LRB- modified AIO regimen -RRB- in patients with metastatic colorectal_cancer -RSB- .
18636363	0	5-FU	47,51	Endostatin	11,21	5-FU	Endostatin	MESH:D005472	80781	Chemical	Gene	combined|nmod|START_ENTITY combined|nsubj|Effect Effect|nmod|END_ENTITY	-LSB- Effect of Endostatin and SU6668 combined with 5-FU on human colon_cancer xenograft in nude_mice -RSB- .
23645743	0	5-FU	72,76	VEGF	31,35	5-FU	VEGF	MESH:D005472	7422	Chemical	Gene	expression|nmod|START_ENTITY expression|nsubj|alteration alteration|nmod|END_ENTITY	Chemotherapeutic alteration of VEGF , PDGF and PDGFRa/b expression under 5-FU vs. docetaxel in HPV-transformed squamous_cell_carcinoma compared to HPV-negative HNSCC in vitro .
23915286	11	5-FU	1628,1632	miR-433	1550,1557	5-FU	miR-433	MESH:D005472	574034	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|inhibition inhibition|amod|END_ENTITY	Furthermore , miR-433 increased inhibition of cell proliferation in HeLa cells treated with 5-FU at over 2.0 M. CONCLUSION : The results indicate that miR-433 post-transcriptionally regulates the expression of TYMS mRNA and protein , and increases sensitivity to 5-FU in HeLa cells .
19836229	0	5-Fluorocytosine	0,16	deoxycytidine_kinase	46,66	5-Fluorocytosine	deoxycytidine kinase	MESH:D005437	13178(Tax:10090)	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	5-Fluorocytosine derivatives as inhibitors of deoxycytidine_kinase .
24434920	0	5-Fluorouracil	85,99	Dihydropyrimidine_Dehydrogenase	0,31	5-Fluorouracil	Dihydropyrimidine Dehydrogenase	MESH:D005472	1806	Chemical	Gene	Ocular_Toxicity|nmod|START_ENTITY Associated|nmod|Ocular_Toxicity Associated|nsubj|Mutation Mutation|compound|END_ENTITY	Dihydropyrimidine_Dehydrogenase 85T > C Mutation Is Associated With Ocular_Toxicity of 5-Fluorouracil : A Case Report .
21224110	0	5-Fluorouracil	24,38	FAP	19,22	5-Fluorouracil	FAP	MESH:D005472	2191	Chemical	Gene	study|dep|START_ENTITY study|nmod|END_ENTITY	A phase I study of FAP -LRB- 5-Fluorouracil , a-interferon and cisplatin -RRB- combined with methotrexate for the treatment of advanced urothelial_malignancies .
11264006	0	5-Fluorouracil	0,14	NF-KappaB	30,39	5-Fluorouracil	NF-KappaB	MESH:D005472	4790	Chemical	Gene	suppression|amod|START_ENTITY suppression|nmod|END_ENTITY	5-Fluorouracil suppression of NF-KappaB is mediated by the inhibition of IKappab kinase activity in human salivary_gland_cancer cells .
2592384	0	5-Fluorouracil	0,14	dihydrofolate_reductase	24,47	5-Fluorouracil	dihydrofolate reductase	MESH:D005472	1719	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|processing processing|amod|END_ENTITY	5-Fluorouracil inhibits dihydrofolate_reductase precursor mRNA processing and/or nuclear mRNA stability in methotrexate-resistant KB cells .
15905808	0	5-Fluorouracil	21,35	dihydropyrimidine_dehydrogenase	132,163	5-Fluorouracil	dihydropyrimidine dehydrogenase	MESH:D005472	1806	Chemical	Gene	detection|amod|START_ENTITY analysis|nmod|detection analysis|nmod|activity activity|compound|END_ENTITY	Improved analysis of 5-Fluorouracil and 5,6-dihydro-5-Fluorouracil by HPLC with diode array detection for determination of cellular dihydropyrimidine_dehydrogenase activity and pharmacokinetic profiling .
21607436	0	5-Fluorouracil	41,55	interferon-alpha-2b	59,78	5-Fluorouracil	interferon-alpha-2b	MESH:D005472	3440	Chemical	Gene	modulation|nmod|START_ENTITY modulation|nmod|END_ENTITY	Double alternate modulation of high-dose 5-Fluorouracil by interferon-alpha-2b and phosphonacetyl-L-aspartic_Acid in patients with advanced colorectal-cancer .
14646558	0	5-Fluorouracil	0,14	p53	82,85	5-Fluorouracil	p53	MESH:D005472	7157	Chemical	Gene	induced|amod|START_ENTITY apoptosis|nsubj|induced apoptosis|dobj|role role|nmod|gene gene|compound|END_ENTITY	5-Fluorouracil -LRB- 5-FU -RRB- induced apoptosis in gastric_cancer cell lines : role of the p53 gene .
23077553	0	5-Fluorouracil	0,14	p53	84,87	5-Fluorouracil	p53	MESH:D005472	22060(Tax:10090)	Chemical	Gene	nanoparticles|amod|START_ENTITY inhibit|nsubj|nanoparticles inhibit|dobj|hepatocellular_carcinoma hepatocellular_carcinoma|nmod|activation activation|nmod|pathway pathway|compound|END_ENTITY	5-Fluorouracil nanoparticles inhibit hepatocellular_carcinoma via activation of the p53 pathway in the orthotopic transplant mouse model .
23108402	0	5-Fluorouracil	0,14	p53	88,91	5-Fluorouracil	p53	MESH:D005472	7157	Chemical	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|compound|END_ENTITY	5-Fluorouracil signaling through a calcium-calmodulin-dependent pathway is required for p53 activation and apoptosis in colon_carcinoma cells .
12138245	0	5-Fluorouracil	10,24	thymidylate_synthase	72,92	5-Fluorouracil	thymidylate synthase	MESH:D005472	22171(Tax:10090)	Chemical	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	High-dose 5-Fluorouracil with uridine-diphosphoglucose rescue increases thymidylate_synthase inhibition but not 5-Fluorouracil incorporation into RNA in murine tumors .
16310373	0	5-Fu	97,101	H-22	80,84	5-Fu	H-22	MESH:D005472	109779(Tax:10090)	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Effect of low molecular lambda-carrageenan from Chondrus ocellatus on antitumor H-22 activity of 5-Fu .
10634307	0	5-HT	112,116	5-HT3_receptor	19,33	5-HT	5-HT3 receptor	MESH:D012701	79246(Tax:10116)	Chemical	Gene	Effects|appos|START_ENTITY Effects|nmod|antagonists antagonists|amod|END_ENTITY	Effects of various 5-HT3_receptor antagonists , granisetron , ondansetron , ramosetron and azasetron on serotonin -LRB- 5-HT -RRB- release from the ferret isolated ileum .
10684896	0	5-HT	16,20	5-HT_transporter	91,107	5-HT	5-HT transporter	MESH:D012701	25553(Tax:10116)	Chemical	Gene	projections|appos|START_ENTITY projections|dep|relation relation|nmod|neurotoxicity neurotoxicity|amod|amphetamine-induced amphetamine-induced|amod|END_ENTITY	Dual serotonin -LRB- 5-HT -RRB- projections to the nucleus accumbens core and shell : relation of the 5-HT_transporter to amphetamine-induced neurotoxicity .
11245702	0	5-HT	63,67	5-HT_transporter	27,43	5-HT	5-HT transporter	MESH:D012701	15567(Tax:10090)	Chemical	Gene	disruption|nmod|START_ENTITY disruption|amod|END_ENTITY	Functional consequences of 5-HT_transporter gene disruption on 5-HT -LRB- 1a -RRB- _ receptor-mediated regulation of dorsal raphe and hippocampal cell activity .
20854367	0	5-HT	94,98	5-HT_transporter	32,48	5-HT	5-HT transporter	MESH:D012701	15567(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Non-linear relationship between 5-HT_transporter gene expression and frequency sensitivity of 5-HT signals .
23318273	0	5-HT	104,108	5-HT_transporter	59,75	5-HT	5-HT transporter	MESH:D012701	25553(Tax:10116)	Chemical	Gene	assessed|nmod|START_ENTITY END_ENTITY|advcl|assessed	Effect of repeated exposure to MDMA on the function of the 5-HT_transporter as assessed by synaptosomal 5-HT uptake .
23547810	0	5-HT	11,15	5-HT_transporter	84,100	5-HT	5-HT transporter	MESH:D012701	15567(Tax:10090)	Chemical	Gene	Serotonin|appos|START_ENTITY Serotonin|dep|insight insight|nmod|models models|amod|END_ENTITY	Serotonin -LRB- 5-HT -RRB- in the regulation of depression-related_emotionality : insight from 5-HT_transporter and tryptophan hydroxylase-2 knockout mouse models .
19288193	0	5-HT	85,89	ALDH	108,112	5-HT	ALDH	MESH:D012701	25375(Tax:10116)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Enhanced 5-HT -LRB- 2A -RRB- receptors in brain stem and ALDH activity in brain stem and liver : 5-HT -LRB- 2A -RRB- regulation on ALDH in primary hepatocytes cultures in vitro .
19288193	0	5-HT	9,13	ALDH	108,112	5-HT	ALDH	MESH:D012701	25375(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY stem|nsubj|receptors stem|dobj|activity activity|dep|regulation regulation|nmod|END_ENTITY	Enhanced 5-HT -LRB- 2A -RRB- receptors in brain stem and ALDH activity in brain stem and liver : 5-HT -LRB- 2A -RRB- regulation on ALDH in primary hepatocytes cultures in vitro .
23981663	0	5-HT	20,24	BDNF	52,56	5-HT	BDNF	MESH:D012701	627	Chemical	Gene	stimulation|amod|START_ENTITY stimulation|nmod|expression expression|amod|END_ENTITY	Effects of repeated 5-HT receptor stimulation on BDNF gene expression and cell survival .
23337348	4	5-HT	1121,1125	CB1	1000,1003	5-HT	CB1	MESH:D012701	25248(Tax:10116)	Chemical	Gene	increased|nsubj|START_ENTITY increased|advcl|increased increased|nsubj|5-HT 5-HT|appos|receptor receptor|compound|END_ENTITY	In the hippocampus , the 5-HT -LRB- 1A -RRB- , CB1 and GABA -LRB- A -RRB- receptor binding densities significantly increased in response to an HF diet , while in the hypothalamus , 5-HT -LRB- 1A -RRB- and CB1 binding densities significantly increased in HF-fed rats .
23337348	4	5-HT	990,994	CB1	1000,1003	5-HT	CB1	MESH:D012701	25248(Tax:10116)	Chemical	Gene	START_ENTITY|appos|receptor receptor|compound|END_ENTITY	In the hippocampus , the 5-HT -LRB- 1A -RRB- , CB1 and GABA -LRB- A -RRB- receptor binding densities significantly increased in response to an HF diet , while in the hypothalamus , 5-HT -LRB- 1A -RRB- and CB1 binding densities significantly increased in HF-fed rats .
23505381	0	5-HT	42,46	DAF-19	25,31	5-HT	DAF-19	MESH:D012701	174577(Tax:6239)	Chemical	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	RFX transcription factor DAF-19 regulates 5-HT and innate immune responses to pathogenic bacteria in Caenorhabditis_elegans .
9359463	0	5-HT	12,16	Fos	25,28	5-HT	Fos	MESH:D012701	314322(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Intradermal 5-HT induces Fos expression in rat dorsal horn neurons not via 5-HT3 but via 5-HT2A receptors .
11904159	0	5-HT	54,58	SERT	73,77	5-HT	SERT	MESH:D012701	6532	Chemical	Gene	transporters|amod|START_ENTITY transporters|appos|END_ENTITY	Voltage-dependent transient currents of human and rat 5-HT transporters -LRB- SERT -RRB- are blocked by HEPES and ion channel ligands .
14622117	0	5-HT	11,15	SERT	30,34	5-HT	SERT	MESH:D012701	25553(Tax:10116)	Chemical	Gene	transporter|appos|START_ENTITY transporter|appos|END_ENTITY	Serotonin -LRB- 5-HT -RRB- transporter -LRB- SERT -RRB- function after graded destruction of serotonergic neurons .
15302679	0	5-HT	49,53	SERT	93,97	5-HT	SERT	MESH:D012701	6532	Chemical	Gene	uptake|appos|START_ENTITY uptake|nmod|transporter transporter|appos|END_ENTITY	Nitric_oxide donors inhibit 5-hydroxytryptamine -LRB- 5-HT -RRB- uptake by the human 5-HT transporter -LRB- SERT -RRB- .
15302679	0	5-HT	75,79	SERT	93,97	5-HT	SERT	MESH:D012701	6532	Chemical	Gene	human|dep|START_ENTITY transporter|amod|human transporter|appos|END_ENTITY	Nitric_oxide donors inhibit 5-hydroxytryptamine -LRB- 5-HT -RRB- uptake by the human 5-HT transporter -LRB- SERT -RRB- .
17509016	0	5-HT	51,55	SERT	45,49	5-HT	SERT	MESH:D012701	6532	Chemical	Gene	Regional|dep|START_ENTITY Regional|dep|differences differences|nmod|expression expression|nmod|END_ENTITY	Regional differences in expression of TPH-1 , SERT , 5-HT -LRB- 3 -RRB- and 5-HT -LRB- 4 -RRB- receptors in the human stomach and duodenum .
18209475	0	5-HT	11,15	SERT	131,135	5-HT	SERT	MESH:D012701	6532	Chemical	Gene	transport|appos|START_ENTITY modulated|nsubjpass|transport modulated|nmod|Tyr-phosphorylation Tyr-phosphorylation|nmod|END_ENTITY	Serotonin -LRB- 5-HT -RRB- transport in human platelets is modulated by Src-catalysed Tyr-phosphorylation of the plasma membrane transporter SERT .
18606402	0	5-HT	81,85	SERT	123,127	5-HT	SERT	MESH:D012701	25553(Tax:10116)	Chemical	Gene	populations|amod|START_ENTITY populations|dep|study study|nmod|rats rats|amod|END_ENTITY	Stress-induced hyperthermia and basal body temperature are mediated by different 5-HT -LRB- 1A -RRB- receptor populations : a study in SERT knockout rats .
22414815	4	5-HT	521,525	SERT	594,598	5-HT	SERT	MESH:D012701	15567(Tax:10090)	Chemical	Gene	transporter|amod|START_ENTITY express|dobj|transporter express|advcl|suggesting suggesting|ccomp|regulate regulate|nsubj|activity activity|amod|END_ENTITY	Embryonic thalamic axons transiently express the 5-HT transporter -LRB- SERT ; Slc6a4 -RRB- and accumulate 5-HT , suggesting that the SERT activity of these axons may regulate 5-HT-modulated guidance cues .
8770136	0	5-HT	0,4	TRH	34,37	5-HT	TRH	MESH:D012701	25569(Tax:10116)	Chemical	Gene	START_ENTITY|dep|effects effects|nmod|END_ENTITY	5-HT in DVC : disparate effects on TRH analogue-stimulated gastric acid secretion , motility , and cytoprotection .
9225129	0	5-HT	11,15	TRH	59,62	5-HT	TRH	MESH:D012701	25569(Tax:10116)	Chemical	Gene	Serotonin|appos|START_ENTITY stimulates|nsubj|Serotonin stimulates|dobj|gene gene|appos|END_ENTITY	Serotonin -LRB- 5-HT -RRB- stimulates thyrotropin-releasing_hormone -LRB- TRH -RRB- gene transcription in rat embryonic cardiomyocytes .
19507004	0	5-HT	20,24	TRPA1	29,34	5-HT	TRPA1	MESH:D012701	8989	Chemical	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	QGP-1 cells release 5-HT via TRPA1 activation ; a model of human enterochromaffin cells .
24820623	0	5-HT	91,95	milk	33,37	5-HT	milk	MESH:D012701	100532204	Chemical	Gene	Analysis|nmod|START_ENTITY Analysis|nmod|END_ENTITY	Analysis of free ACh and 5-HT in milk from four different species and their bioactivity on 5-HT -LRB- 3 -RRB- and nACh receptors .
8764208	0	5-HT	8,12	mucin	38,43	5-HT	mucin	MESH:D012701	65202(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|secretion secretion|compound|END_ENTITY	Role of 5-HT in cholera toxin-induced mucin secretion in the rat small intestine .
11018311	0	5-HTTLPR	64,72	serotonin_transporter	73,94	5-HTTLPR	serotonin transporter	null	6532	Chemical	Gene	polymorphism|amod|START_ENTITY polymorphism|compound|END_ENTITY	An association study of bipolar_mood_disorder -LRB- type I -RRB- with the 5-HTTLPR serotonin_transporter polymorphism in a human population isolate from Colombia .
16380252	0	5-Heteroatom-substituted_pyrazoles	0,34	COX-2	45,50	5-Heteroatom-substituted pyrazoles	COX-2	null	4513	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	5-Heteroatom-substituted_pyrazoles as canine COX-2 inhibitors : Part 2 .
22484311	0	5-Hydroxy-7-methoxyflavone	0,26	Tec	164,167	5-Hydroxy-7-methoxyflavone	Tec	MESH:C574159	7006	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|nmod|END_ENTITY	5-Hydroxy-7-methoxyflavone inhibits N-formyl-L-methionyl-L-leucyl-L-phenylalanine-induced superoxide anion production by specific modulate membrane localization of Tec with a PI3K independent mechanism in human neutrophils .
23422309	0	5-Hydroxymethylfurfural	0,23	ADH7	32,36	5-Hydroxymethylfurfural	ADH7	MESH:C008046	850469(Tax:4932)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	5-Hydroxymethylfurfural induces ADH7 and ARI1 expression in tolerant industrial Saccharomyces_cerevisiae_strain P6H9 during bioethanol production .
3402898	0	5-Hydroxytryptamine	0,19	5-HT1A	157,163	5-Hydroxytryptamine	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|parataxis|related related|nmod|subtype subtype|amod|different different|nmod|END_ENTITY	5-Hydroxytryptamine stimulates two distinct adenylate cyclase activities in rat brain : high-affinity activation is related to a 5-HT1 subtype different from 5-HT1A , 5-HT1B , and 5-HT1C .
8584040	0	5-Hydroxytryptamine	0,19	5-HT1D	20,26	5-Hydroxytryptamine	5-HT1D	MESH:D012701	403963(Tax:9615)	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	5-Hydroxytryptamine 5-HT1D receptors mediating inhibition of cyclic_AMP accumulation in Madin-Darby canine kidney -LRB- MDCK -RRB- cells .
6201770	0	5-Hydroxytryptamine	0,19	prolactin	98,107	5-Hydroxytryptamine	prolactin	MESH:D012701	24683(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY synthesis|nmod|END_ENTITY	5-Hydroxytryptamine synthesis and metabolism in discrete nuclei of the rat brain during surges of prolactin associated with restraint stress or suckling .
8301554	0	5-Hydroxytryptamine2	0,20	alpha-melanocyte-stimulating_hormone	133,169	5-Hydroxytryptamine2	alpha-melanocyte-stimulating hormone	null	5443	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	5-Hydroxytryptamine2 receptor-mediated regulation of periventricular-hypophysial dopaminergic neuronal activity and the secretion of alpha-melanocyte-stimulating_hormone .
26517378	0	5-Methoxyflavone	18,34	DNA_Polymerase-Beta	46,65	5-Methoxyflavone	DNA Polymerase-Beta	null	5423	Chemical	Gene	START_ENTITY|nmod|Inhibitor Inhibitor|compound|END_ENTITY	Identification of 5-Methoxyflavone as a Novel DNA_Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity .
25923513	0	5-Methoxyquinoline	0,18	EZH2	49,53	5-Methoxyquinoline	EZH2	null	14056(Tax:10090)	Chemical	Gene	Derivatives|amod|START_ENTITY Derivatives|nmod|Inhibitors Inhibitors|compound|END_ENTITY	5-Methoxyquinoline Derivatives as a New Class of EZH2 Inhibitors .
7966138	0	5-Phenyl-3-ureidobenzazepin-2-ones	0,34	cholecystokinin-B_receptor	38,64	5-Phenyl-3-ureidobenzazepin-2-ones	cholecystokinin-B receptor	null	887	Chemical	Gene	START_ENTITY|nmod|antagonists antagonists|amod|END_ENTITY	5-Phenyl-3-ureidobenzazepin-2-ones as cholecystokinin-B_receptor antagonists .
12170180	0	5-S-cysteinyldopa	136,153	Melanoma_inhibitory_activity	0,28	5-S-cysteinyldopa	Melanoma inhibitory activity	MESH:D003548	8190	Chemical	Gene	comparison|nmod|START_ENTITY END_ENTITY|dep|comparison	Melanoma_inhibitory_activity -LRB- MIA -RRB- as a serum marker for early detection of post-surgical relapse in melanoma patients : comparison with 5-S-cysteinyldopa .
21800646	0	5-amino-4-acylamino-1H-pyrazole	25,56	furin	74,79	5-amino-4-acylamino-1H-pyrazole	furin	null	5045	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	-LSB- Study on derivatives of 5-amino-4-acylamino-1H-pyrazole as inhibitors of furin -RSB- .
18035054	0	5-amino-4-imidazolecarboxamide_riboside	110,149	insulin	44,51	5-amino-4-imidazolecarboxamide riboside	insulin	null	3630	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Transcriptional mechanism of suppression of insulin gene expression by AMP-activated_protein_kinase activator 5-amino-4-imidazolecarboxamide_riboside -LRB- AICAR -RRB- in beta-cells .
20362304	0	5-aminoimidazole-4-carboxamide-1-b-D-ribofuranoside	70,121	sirtuin_1	146,155	5-aminoimidazole-4-carboxamide-1-b-D-ribofuranoside	sirtuin 1	null	309757(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY increases|nsubj|treatment increases|dobj|expression expression|amod|END_ENTITY	Short-term adenosine_monophosphate-activated protein kinase activator 5-aminoimidazole-4-carboxamide-1-b-D-ribofuranoside treatment increases the sirtuin_1 protein expression in skeletal muscle .
19144636	0	5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside	105,159	AMP-activated_protein_kinase	0,28	5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside	AMP-activated protein kinase	null	5564	Chemical	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	AMP-activated_protein_kinase is involved in neural stem cell growth suppression and cell cycle arrest by 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside and glucose_deprivation by down-regulating phospho-retinoblastoma protein and cyclin D .
9500985	0	5-aminoimidazole-4-carboxamide_ribonucleoside	52,97	AMP-activated_protein_kinase	129,157	5-aminoimidazole-4-carboxamide ribonucleoside	AMP-activated protein kinase	null	78975(Tax:10116)	Chemical	Gene	START_ENTITY|appos|activator activator|nmod|END_ENTITY	Inhibition of glucocorticoid-induced apoptosis with 5-aminoimidazole-4-carboxamide_ribonucleoside , a cell-permeable activator of AMP-activated_protein_kinase .
11267664	0	5-aminolevulinate	86,103	ALAS1	114,119	5-aminolevulinate	ALAS1	MESH:D000622	211	Chemical	Gene	genes|amod|START_ENTITY genes|amod|synthase synthase|dep|END_ENTITY	Alternative splicing and tissue-specific transcription of human and rodent ubiquitous 5-aminolevulinate synthase -LRB- ALAS1 -RRB- genes .
19656447	0	5-aminolevulinate	55,72	ALAS1	83,88	5-aminolevulinate	ALAS1	MESH:D000622	211	Chemical	Gene	synthase|amod|START_ENTITY gene|amod|synthase gene|appos|END_ENTITY	Functional analysis of the 5 ' regulatory region of the 5-aminolevulinate synthase -LRB- ALAS1 -RRB- gene in response to estrogen .
26910002	0	5-aminolevulinate	76,93	ALAS1	106,111	5-aminolevulinate	ALAS1	MESH:D000622	211	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Short Communication Molecular cloning and expression pattern of the porcine 5-aminolevulinate synthase 1 -LRB- ALAS1 -RRB- gene and its association with reproductive traits .
10029606	0	5-aminolevulinate	45,62	ALAS2	73,78	5-aminolevulinate	ALAS2	MESH:D000622	212	Chemical	Gene	synthase|amod|START_ENTITY gene|amod|synthase gene|appos|END_ENTITY	Four new mutations in the erythroid-specific 5-aminolevulinate synthase -LRB- ALAS2 -RRB- gene causing X-linked_sideroblastic_anemia : increased pyridoxine responsiveness after removal of iron overload by phlebotomy and coinheritance of hereditary_hemochromatosis .
12663458	0	5-aminolevulinate	46,63	ALAS2	74,79	5-aminolevulinate	ALAS2	MESH:D000622	212	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A promoter mutation in the erythroid-specific 5-aminolevulinate synthase -LRB- ALAS2 -RRB- gene causes X-linked_sideroblastic_anemia .
15885606	0	5-aminolevulinate	127,144	ALAS2	155,160	5-aminolevulinate	ALAS2	MESH:D000622	212	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Iron_overload in an African American woman with SS_hemoglobinopathy and a promoter mutation in the X-linked erythroid-specific 5-aminolevulinate synthase -LRB- ALAS2 -RRB- gene .
15946643	0	5-aminolevulinate	87,104	insulin	10,17	5-aminolevulinate	insulin	MESH:D000622	396145(Tax:9031)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of insulin and glucagon on accumulation of uroporphyrin and coproporphyrin from 5-aminolevulinate in hepatocyte cultures .
12121995	0	5-aminolevulinic_acid	52,73	ALAS1	84,89	5-aminolevulinic acid	ALAS1	CHEBI:17549	552895(Tax:9031)	Chemical	Gene	synthase|amod|START_ENTITY gene|amod|synthase gene|appos|END_ENTITY	Drugs mediate the transcriptional activation of the 5-aminolevulinic_acid synthase -LRB- ALAS1 -RRB- gene via the chicken xenobiotic-sensing nuclear receptor -LRB- CXR -RRB- .
12121995	0	5-aminolevulinic_acid	52,73	CXR	149,152	5-aminolevulinic acid	CXR	CHEBI:17549	395439(Tax:9031)	Chemical	Gene	synthase|amod|START_ENTITY gene|amod|synthase gene|appos|END_ENTITY	Drugs mediate the transcriptional activation of the 5-aminolevulinic_acid synthase -LRB- ALAS1 -RRB- gene via the chicken xenobiotic-sensing nuclear receptor -LRB- CXR -RRB- .
24535911	0	5-aminolevulinic_acid	21,42	aquaporin	59,68	5-aminolevulinic acid	aquaporin	CHEBI:17549	101215145	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Effects of exogenous 5-aminolevulinic_acid on PIP1 and NIP aquaporin gene expression in seedlings of cucumber cultivars subjected to salinity stress .
16461476	0	5-aminosalicylic_acid	52,73	trefoil_factor_3	91,107	5-aminosalicylic acid	trefoil factor 3	MESH:D019804	25563(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effects of topical treatment of sodium_butyrate and 5-aminosalicylic_acid on expression of trefoil_factor_3 , interleukin_1beta , and nuclear factor kappaB in trinitrobenzene_sulphonic_acid induced colitis in rats .
20469868	0	5-arylindazole	27,41	glucocorticoid_receptor	42,65	5-arylindazole	glucocorticoid receptor	null	2908	Chemical	Gene	agonists|amod|START_ENTITY agonists|compound|END_ENTITY	Structure guided design of 5-arylindazole glucocorticoid_receptor agonists and antagonists .
25860431	0	5-aza-2-Deoxycytidine	73,94	DNMT1	18,23	5-aza-2-Deoxycytidine	DNMT1	MESH:C014347	1786	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	The Expression of DNMT1 in Pathologic Scar Fibroblasts and the Effect of 5-aza-2-Deoxycytidine on Cytokines of Pathologic Scar Fibroblasts .
26463020	0	5-aza-2-deoxycytidine	20,41	maternally_expressed_gene_3	49,76	5-aza-2-deoxycytidine	maternally expressed gene 3	MESH:C014347	55384	Chemical	Gene	START_ENTITY|nmod|promoter promoter|amod|END_ENTITY	-LSB- Reversal effect of 5-aza-2-deoxycytidine on the maternally_expressed_gene_3 promoter hypermethylation and its inhibitory effect on the proliferation of epithelial_ovarian_cancer cells -RSB- .
22246465	4	5-aza-CdR	1047,1056	DAPK	987,991	5-aza-CdR	DAPK	null	1612	Chemical	Gene	treatment|amod|START_ENTITY END_ENTITY|nmod|treatment	In the SN38-resistant subclones , no relationships were found between the restored SN38 sensitivity and hypermethylation of the DAPK promoter , DAPK mRNA expression , DAPK protein expression and induction of DAPK protein after 5-aza-CdR treatment , unlike the strong suppression of 5-aza-CdR-induced DAPK protein expression in the cisplatin-resistant subclones .
14722112	5	5-aza-CdR	897,906	p21	915,918	5-aza-CdR	CdR	null	1038	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Furthermore , deletion analysis and site-directed mutagenesis of the p21 promoter reveals that 5-aza-CdR induces p21 -LRB- Waf1/Cip1 -RRB- expression through two p53 binding sites in the p21 promoter .
1690260	0	5-azacytidine	77,90	E1a	115,118	5-azacytidine	E1a	MESH:D001374	25244(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|reactivation reactivation|nmod|END_ENTITY	Drug-induced revertants of adenovirus-transformed cells : retransformation by 5-azacytidine without reactivation of E1a .
21907333	0	5-azacytidine	51,64	PD-1	21,25	5-azacytidine	PD-1	MESH:D001374	5133	Chemical	Gene	expression|amod|START_ENTITY induced|nmod|expression induced|nsubj|demethylation demethylation|nmod|promoter promoter|compound|END_ENTITY	DNA demethylation in PD-1 gene promoter induced by 5-azacytidine activates PD-1 expression on Molt-4 cells .
24940389	0	5-azacytidine	55,68	PTEN	25,29	5-azacytidine	PTEN	MESH:D001374	5728	Chemical	Gene	expression|amod|START_ENTITY induced|nmod|expression induced|nsubj|demethylation demethylation|nmod|promoter promoter|compound|END_ENTITY	DNA demethylation in the PTEN gene promoter induced by 5-azacytidine activates PTEN expression in the MG-63 human osteosarcoma cell line .
24940389	0	5-azacytidine	55,68	PTEN	79,83	5-azacytidine	PTEN	MESH:D001374	5728	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	DNA demethylation in the PTEN gene promoter induced by 5-azacytidine activates PTEN expression in the MG-63 human osteosarcoma cell line .
26547689	0	5-azacytidine	32,45	SHP-1	10,15	5-azacytidine	SHP-1	MESH:D001374	5777	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Enhancing SHP-1 expression with 5-azacytidine may inhibit STAT3 activation and confer sensitivity in lestaurtinib -LRB- CEP-701 -RRB- - resistant FLT3-ITD positive acute_myeloid_leukemia .
12749850	0	5-azacytidine	70,83	TIMP-2	18,24	5-azacytidine	TIMP-2	MESH:D001374	7077	Chemical	Gene	cells|nmod|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	Reconstitution of TIMP-2 expression in SH-SY5Y neuroblastoma cells by 5-azacytidine is mediated transcriptionally by NF-Y through an inverted CCAAT site .
6197072	0	5-azacytidine	10,23	alpha-fetoprotein	37,54	5-azacytidine	alpha-fetoprotein	MESH:D001374	24177(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Effect of 5-azacytidine on rat liver alpha-fetoprotein gene expression .
2439195	0	5-azacytidine	10,23	deoxycytidine_kinase	75,95	5-azacytidine	deoxycytidine kinase	MESH:D001374	1633	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of 5-azacytidine and congeners on DNA methylation and expression of deoxycytidine_kinase in the human lymphoid cell lines CCRF/CEM/0 and CCRF/CEM/dCk -1 .
19743867	0	5-azaindole	138,149	CB2	150,153	5-azaindole	CB2	MESH:C512290	1269	Chemical	Gene	agonist|amod|START_ENTITY agonist|compound|END_ENTITY	Discovery of 1 - -LSB- 4 - -LRB- 3-chlorophenylamino -RRB- -1 - methyl-1H-pyrrolo -LSB- 3,2-c -RSB- pyridin-7-yl -RSB- -1 - morpholin-4-ylmethanone -LRB- GSK554418A -RRB- , a brain penetrant 5-azaindole CB2 agonist for the treatment of chronic_pain .
26095345	0	5-benzylidenerhodanine-3-acetic_acid	39,75	AChE	91,95	5-benzylidenerhodanine-3-acetic acid	AChE	null	43	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Synthesis and biological evaluation of 5-benzylidenerhodanine-3-acetic_acid derivatives as AChE and 15-LOX inhibitors .
7923135	0	5-benzyloxybenzyluracil	86,109	dihydrouracil_dehydrogenase	47,74	5-benzyloxybenzyluracil	dihydrouracil dehydrogenase	MESH:C068991	99586(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Potentiation of 5-fluorouracil efficacy by the dihydrouracil_dehydrogenase inhibitor , 5-benzyloxybenzyluracil .
19906467	0	5-benzylpaullones	15,32	mMDH	140,144	5-benzylpaullones	mMDH	null	17448(Tax:10090)	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	Development of 5-benzylpaullones and paullone-9-carboxylic_acid_alkyl_esters as selective inhibitors of mitochondrial malate dehydrogenase -LRB- mMDH -RRB- .
7160227	0	5-bromodeoxyuridine	10,29	LDH-X	50,55	5-bromodeoxyuridine	LDH-X	MESH:D001973	16833(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|synthesis synthesis|nmod|END_ENTITY	Effect of 5-bromodeoxyuridine on the synthesis of LDH-X in the postnatal testis of mouse .
8144562	0	5-deazaacyclotetrahydrofolate	76,105	folylpolyglutamate_synthetase	8,37	5-deazaacyclotetrahydrofolate	folylpolyglutamate synthetase	null	2356	Chemical	Gene	metabolism|nmod|START_ENTITY Role|nmod|metabolism Role|nmod|END_ENTITY	Role of folylpolyglutamate_synthetase in the metabolism and cytotoxicity of 5-deazaacyclotetrahydrofolate , an anti-purine drug .
2622477	0	5-fluorocytosine	10,26	cytochrome_P_450	71,87	5-fluorocytosine	cytochrome P 450	MESH:D005437	25251(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of 5-fluorocytosine and 5-fluorouracil on human and rat hepatic cytochrome_P_450 .
7449757	0	5-fluorodeoxyuridylate	31,53	thymidylate_synthetase	80,102	5-fluorodeoxyuridylate	thymidylate synthetase	null	7298	Chemical	Gene	inactivation|amod|START_ENTITY inactivation|nmod|END_ENTITY	Activation and protection from 5-fluorodeoxyuridylate inactivation of mammalian thymidylate_synthetase by pyridoxal_5 ' - phosphate .
23355249	0	5-fluorouracil	11,25	ATP-binding_cassette_superfamily_G_member_2	47,90	5-fluorouracil	ATP-binding cassette superfamily G member 2	MESH:D005472	9429	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of 5-fluorouracil on the expression of ATP-binding_cassette_superfamily_G_member_2 in human colon_cancer cell SW480 -RSB- .
18820913	0	5-fluorouracil	57,71	BCRP	8,12	5-fluorouracil	BCRP	MESH:D005472	26357(Tax:10090)	Chemical	Gene	predicting|nmod|START_ENTITY Role|acl|predicting Role|nmod|END_ENTITY	Role of BCRP as a biomarker for predicting resistance to 5-fluorouracil in breast_cancer .
21601882	0	5-fluorouracil	90,104	CD133	0,5	5-fluorouracil	CD133	MESH:D005472	8842	Chemical	Gene	resistant|nmod|START_ENTITY resistant|nsubj|cells cells|compound|END_ENTITY	CD133 -LRB- - -RRB- cells , derived from a single human colon_cancer cell line , are more resistant to 5-fluorouracil -LRB- FU -RRB- than CD133 -LRB- + -RRB- cells , dependent on the b1-integrin signaling .
21601882	0	5-fluorouracil	90,104	CD133	115,120	5-fluorouracil	CD133	MESH:D005472	8842	Chemical	Gene	START_ENTITY|nmod|cells cells|amod|END_ENTITY	CD133 -LRB- - -RRB- cells , derived from a single human colon_cancer cell line , are more resistant to 5-fluorouracil -LRB- FU -RRB- than CD133 -LRB- + -RRB- cells , dependent on the b1-integrin signaling .
24339132	0	5-fluorouracil	50,64	CD133	0,5	5-fluorouracil	CD133	MESH:D005472	8842	Chemical	Gene	susceptibility|compound|START_ENTITY linked|nmod|susceptibility linked|nsubj|nucleophosmin nucleophosmin|compound|END_ENTITY	CD133 and CD133-regulated nucleophosmin linked to 5-fluorouracil susceptibility in human colon_cancer cell line SW620 .
25230779	0	5-fluorouracil	52,66	CD133	18,23	5-fluorouracil	CD133	MESH:D005472	8842	Chemical	Gene	chemoresistance|nmod|START_ENTITY enhances|xcomp|chemoresistance enhances|nsubj|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of CD133 enhances chemoresistance to 5-fluorouracil by activating the PI3K/Akt/p70S6K pathway in gastric_cancer cells .
16608024	0	5-fluorouracil	46,60	CPT-11	19,25	5-fluorouracil	CPT-11	MESH:D005472	963084(Tax:115711)	Chemical	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	A phase I trial of CPT-11 in combination with 5-fluorouracil plus leucovorin chemotherapy for patients with metastatic colorectal_cancer .
24293105	0	5-fluorouracil	81,95	Carcinoembryonic_antigen	0,24	5-fluorouracil	Carcinoembryonic antigen	MESH:D005472	1084	Chemical	Gene	level|nmod|START_ENTITY level|nsubj|expression expression|compound|END_ENTITY	Carcinoembryonic_antigen expression level as a predictive factor for response to 5-fluorouracil in colorectal_cancer .
14607657	0	5-fluorouracil	51,65	Caspase-8	0,9	5-fluorouracil	Caspase-8	MESH:D005472	841	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|END_ENTITY	Caspase-8 in apoptosis of hepatoma cell induced by 5-fluorouracil .
24351824	0	5-fluorouracil	30,44	Cbl-b	0,5	5-fluorouracil	Cbl-b	MESH:D005472	868	Chemical	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	Cbl-b enhances sensitivity to 5-fluorouracil via EGFR - and mitochondria-mediated pathways in gastric_cancer cells .
24005798	0	5-fluorouracil	150,164	Diamine_oxidase	0,15	5-fluorouracil	Diamine oxidase	MESH:D005472	65029(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY END_ENTITY|nmod|treatment	Diamine_oxidase as a marker of intestinal mucosal_injury and the effect of soluble dietary fiber on gastrointestinal tract toxicity after intravenous 5-fluorouracil treatment in rats .
10213225	0	5-fluorouracil	107,121	Dihydropyrimidine_dehydrogenase	0,31	5-fluorouracil	Dihydropyrimidine dehydrogenase	MESH:D005472	1806	Chemical	Gene	effect|nmod|START_ENTITY related|nmod|effect related|nsubjpass|activity activity|amod|END_ENTITY	Dihydropyrimidine_dehydrogenase activity and messenger RNA level may be related to the antitumor effect of 5-fluorouracil on human tumor xenografts in nude_mice .
10744051	0	5-fluorouracil	114,128	Dihydropyrimidine_dehydrogenase	0,31	5-fluorouracil	Dihydropyrimidine dehydrogenase	MESH:D005472	1806	Chemical	Gene	sensitivity|nmod|START_ENTITY predictor|nmod|sensitivity levels|dep|predictor levels|amod|END_ENTITY	Dihydropyrimidine_dehydrogenase and messenger RNA levels in gastric_cancer : possible predictor for sensitivity to 5-fluorouracil .
11501504	0	5-fluorouracil	104,118	Dihydropyrimidine_dehydrogenase	0,31	5-fluorouracil	Dihydropyrimidine dehydrogenase	MESH:D005472	1806	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|activity activity|amod|END_ENTITY	Dihydropyrimidine_dehydrogenase activity and thymidylate_synthase level are associated with response to 5-fluorouracil in human colorectal_cancer .
14551502	0	5-fluorouracil	88,102	Dihydropyrimidine_dehydrogenase	0,31	5-fluorouracil	Dihydropyrimidine dehydrogenase	MESH:D005472	1806	Chemical	Gene	administration|nmod|START_ENTITY strategy|nmod|administration inhibition|nmod|strategy inhibition|amod|END_ENTITY	Dihydropyrimidine_dehydrogenase inhibition as a strategy for the oral administration of 5-fluorouracil : utility in the treatment of advanced colorectal_cancer .
15093568	0	5-fluorouracil	65,79	Dihydropyrimidine_dehydrogenase	0,31	5-fluorouracil	Dihydropyrimidine dehydrogenase	MESH:D005472	1806	Chemical	Gene	efficacy|nmod|START_ENTITY END_ENTITY|dobj|efficacy	Dihydropyrimidine_dehydrogenase and the efficacy and toxicity of 5-fluorouracil .
15377401	0	5-fluorouracil	135,149	Dihydropyrimidine_dehydrogenase	0,31	5-fluorouracil	Dihydropyrimidine dehydrogenase	MESH:D005472	1806	Chemical	Gene	administration|compound|START_ENTITY toxicity|nmod|administration associated|nmod|toxicity syndrome|acl|associated deficiency|appos|syndrome deficiency|amod|END_ENTITY	Dihydropyrimidine_dehydrogenase deficiency , a pharmacogenetic syndrome associated with potentially life-threatening toxicity following 5-fluorouracil administration .
15598584	0	5-fluorouracil	93,107	Dihydropyrimidine_dehydrogenase	0,31	5-fluorouracil	Dihydropyrimidine dehydrogenase	MESH:D005472	1806	Chemical	Gene	predicts|nmod|START_ENTITY predicts|nsubj|expression expression|amod|END_ENTITY	Dihydropyrimidine_dehydrogenase expression predicts survival outcome and chemosensitivity to 5-fluorouracil in patients with oral_squamous_cell_carcinoma .
16163233	0	5-fluorouracil	74,88	Dihydropyrimidine_dehydrogenase	0,31	5-fluorouracil	Dihydropyrimidine dehydrogenase	MESH:D005472	1806	Chemical	Gene	therapy|compound|START_ENTITY pharmacogenetics|nmod|therapy impact|nmod|pharmacogenetics deficiency|dep|impact deficiency|amod|END_ENTITY	Dihydropyrimidine_dehydrogenase deficiency : impact of pharmacogenetics on 5-fluorouracil therapy .
21919607	0	5-fluorouracil	68,82	Dihydropyrimidine_dehydrogenase	0,31	5-fluorouracil	Dihydropyrimidine dehydrogenase	MESH:D005472	1806	Chemical	Gene	toxicity|compound|START_ENTITY predictor|nmod|toxicity END_ENTITY|nmod|predictor	Dihydropyrimidine_dehydrogenase gene as a major predictor of severe 5-fluorouracil toxicity .
8996526	0	5-fluorouracil	156,170	Dihydropyrimidine_dehydrogenase	0,31	5-fluorouracil	Dihydropyrimidine dehydrogenase	MESH:D005472	1806	Chemical	Gene	data|nmod|START_ENTITY allometric_scaling|nmod|data inactivation|dep|allometric_scaling inactivation|amod|END_ENTITY	Dihydropyrimidine_dehydrogenase inactivation and 5-fluorouracil pharmacokinetics : allometric_scaling of animal data , pharmacokinetics and toxicodynamics of 5-fluorouracil in humans .
9951876	0	5-fluorouracil	105,119	Dihydropyrimidine_dehydrogenase	0,31	5-fluorouracil	Dihydropyrimidine dehydrogenase	MESH:D005472	1806	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|expression expression|amod|END_ENTITY	Dihydropyrimidine_dehydrogenase but not thymidylate synthase expression is associated with resistance to 5-fluorouracil in colorectal_cancer .
14679120	0	5-fluorouracil	126,140	E2F-1	62,67	5-fluorouracil	E2F-1	MESH:D005472	1869	Chemical	Gene	Lack|nmod|START_ENTITY Lack|nmod|END_ENTITY	Lack of correlation between immunohistochemical expression of E2F-1 , thymidylate_synthase expression and clinical response to 5-fluorouracil in advanced colorectal_cancer .
2741218	0	5-fluorouracil	70,84	FAC	119,122	5-fluorouracil	FAC	MESH:D005472	2176	Chemical	Gene	Combination|nmod|START_ENTITY Combination|appos|END_ENTITY	Combination of cyclophosphamide , adriamycin and platinum -LRB- CAP -RRB- versus 5-fluorouracil , adriamycin and cyclophosphamide -LRB- FAC -RRB- as primary treatment in metastatic breast_cancer : results of a prospective randomized study .
4039985	0	5-fluorouracil	18,32	FAP	60,63	5-fluorouracil	FAP	MESH:D005472	2191	Chemical	Gene	trial|nmod|START_ENTITY trial|appos|END_ENTITY	Phase II trial of 5-fluorouracil , _ adriamycin_and_cisplatin -LRB- FAP -RRB- in advanced gastric_cancer .
1609455	0	5-fluorouracil	15,29	FIB-P	77,82	5-fluorouracil	FIB-P	MESH:D005472	9158	Chemical	Gene	Combination|nmod|START_ENTITY Combination|appos|END_ENTITY	Combination of 5-fluorouracil , imidazole_carboxamide , BCNU and prednisolone -LRB- FIB-P -RRB- as a salvage chemotherapy in heavily pretreated breast_cancer patients .
9856651	0	5-fluorouracil	20,34	FLAME	105,110	5-fluorouracil	FLAME	MESH:D005472	8837	Chemical	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Phase I-II study of 5-fluorouracil , leucovorin , doxorubicin , methotrexate , and long-term oral etoposide -LRB- FLAME -RRB- in unresectable or metastatic gastric_cancer .
15095856	0	5-fluorouracil	63,77	Growth_hormone	0,14	5-fluorouracil	Growth hormone	MESH:D005472	81668(Tax:10116)	Chemical	Gene	toxicity|compound|START_ENTITY protects|nmod|toxicity protects|nsubj|END_ENTITY	Growth_hormone protects the intestines but not the tumour from 5-fluorouracil toxicity in the short term in the rat .
18930000	0	5-fluorouracil	50,64	HuH-7	113,118	5-fluorouracil	HuH-7	MESH:D005472	284424	Chemical	Gene	effect|nmod|START_ENTITY enhances|dobj|effect enhances|nmod|END_ENTITY	Rare sugar D-allose enhances anti-tumor effect of 5-fluorouracil on the human hepatocellular_carcinoma cell line HuH-7 .
10791219	0	5-fluorouracil	32,46	Interleukin-2	0,13	5-fluorouracil	Interleukin-2	MESH:D005472	3558	Chemical	Gene	modulator|nmod|START_ENTITY END_ENTITY|nmod|modulator	Interleukin-2 as a modulator of 5-fluorouracil in hepatic arterial immunochemotherapy for liver metastases .
21078976	0	5-fluorouracil	34,48	MicroRNA-21	0,11	5-fluorouracil	MicroRNA-21	MESH:D005472	406991	Chemical	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS_homolog_2 -LRB- hMSH2 -RRB- .
25132574	0	5-fluorouracil	47,61	MicroRNA-21	8,19	5-fluorouracil	MicroRNA-21	MESH:D005472	406991	Chemical	Gene	predict|nmod|START_ENTITY predict|nsubj|levels levels|compound|END_ENTITY	Stromal MicroRNA-21 levels predict response to 5-fluorouracil in patients with pancreatic_cancer .
10769638	0	5-fluorouracil	12,26	P53	125,128	5-fluorouracil	P53	MESH:D005472	7157	Chemical	Gene	Response|nmod|START_ENTITY Response|dep|influence influence|nmod|status status|compound|END_ENTITY	Response to 5-fluorouracil of orthotopically xenografted human colon_cancers with a microsatellite_instability : influence of P53 status .
11802206	0	5-fluorouracil	63,77	P53	0,3	5-fluorouracil	P53	MESH:D005472	7157	Chemical	Gene	predicts|nmod|START_ENTITY predicts|nsubj|overexpression overexpression|compound|END_ENTITY	P53 overexpression predicts poor chemosensitivity to high-dose 5-fluorouracil plus leucovorin chemotherapy for stage IV colorectal_cancers after palliative bowel resection .
7874692	2	5-fluorouracil	125,139	PAF	63,66	5-fluorouracil	PAF	MESH:D005472	109585(Tax:10090)	Chemical	Gene	dose|nmod|START_ENTITY END_ENTITY|nmod|dose	Modifications of spleen and thymus PAF contents after a single dose of the chemotherapeutic drug 5-fluorouracil in mice .
10200349	0	5-fluorouracil	86,100	Proliferating_cell_nuclear_antigen	0,34	5-fluorouracil	Proliferating cell nuclear antigen	MESH:D005472	5111	Chemical	Gene	administration|compound|START_ENTITY END_ENTITY|nmod|administration	Proliferating_cell_nuclear_antigen as a predictor of therapeutic effect of continuous 5-fluorouracil administration in gastric_cancer .
21410040	0	5-fluorouracil	66,80	RhoGDI2	15,22	5-fluorouracil	RhoGDI2	MESH:D005472	397	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of RhoGDI2 in the resistance of colon_cancer cells to 5-fluorouracil .
12942110	0	5-fluorouracil	25,39	S-1	92,95	5-fluorouracil	S-1	MESH:D005472	5707	Chemical	Gene	START_ENTITY|nmod|administration administration|nmod|END_ENTITY	Plasma concentrations of 5-fluorouracil and F-beta-alanine following oral administration of S-1 , a dihydropyrimidine dehydrogenase inhibitory fluoropyrimidine , as compared with protracted venous infusion of 5-fluorouracil .
16144935	0	5-fluorouracil	29,43	SMAD4	0,5	5-fluorouracil	SMAD4	MESH:D005472	4089	Chemical	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	SMAD4 levels and response to 5-fluorouracil in colorectal_cancer .
25249558	0	5-fluorouracil	34,48	SNAI2	0,5	5-fluorouracil	SNAI2	MESH:D005472	6591	Chemical	Gene	sensitivity|compound|START_ENTITY modulates|dobj|sensitivity modulates|nsubj|END_ENTITY	SNAI2 modulates colorectal_cancer 5-fluorouracil sensitivity through miR145 repression .
26647806	0	5-fluorouracil	38,52	Smad4	0,5	5-fluorouracil	Smad4	MESH:D005472	17128(Tax:10090)	Chemical	Gene	colorectal_cancer|xcomp|START_ENTITY colorectal_cancer|nsubj|sensitizes sensitizes|amod|END_ENTITY	Smad4 sensitizes colorectal_cancer to 5-fluorouracil through cell cycle arrest by inhibiting the PI3K/Akt/CDC2 / survivin cascade .
7642571	0	5-fluorouracil	83,97	Thymidine_phosphorylase	0,23	5-fluorouracil	Thymidine phosphorylase	MESH:D005472	1890	Chemical	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Thymidine_phosphorylase mediates the sensitivity of human colon_carcinoma cells to 5-fluorouracil .
18612238	0	5-fluorouracil	96,110	Thymidylate_synthase	0,20	5-fluorouracil	Thymidylate synthase	MESH:D005472	172149(Tax:6239)	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|levels levels|amod|END_ENTITY	Thymidylate_synthase and dihydropyrimidine dehydrogenase levels are associated with response to 5-fluorouracil in Caenorhabditis_elegans .
25721610	0	5-fluorouracil	82,96	Thymidylate_synthase	0,20	5-fluorouracil	Thymidylate synthase	MESH:D005472	7298	Chemical	Gene	resistance|compound|START_ENTITY predict|dobj|resistance tool|acl|predict END_ENTITY|dobj|tool	Thymidylate_synthase expression in circulating tumor cells : A new tool to predict 5-fluorouracil resistance in metastatic colorectal_cancer patients .
22508373	0	5-fluorouracil	30,44	UGT1A1	149,155	5-fluorouracil	UGT1A1	MESH:D005472	54658	Chemical	Gene	study|nmod|START_ENTITY END_ENTITY|nsubj|study	A phase I study of infusional 5-fluorouracil , leucovorin , oxaliplatin and irinotecan in Japanese patients with advanced colorectal_cancer who harbor UGT1A1 * 1 / * 1 , * 1 / * 6 or * 1 / * 28 .
20448262	0	5-fluorouracil	19,33	alpha-fetoprotein	37,54	5-fluorouracil	alpha-fetoprotein	MESH:D005472	11576(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Specific effect of 5-fluorouracil on alpha-fetoprotein gene expression during the in vitro mouse embryonic stem cell differentiation .
22088286	0	5-fluorouracil	81,95	c-myc	55,60	5-fluorouracil	c-myc	MESH:D005472	4609	Chemical	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	-LSB- Inhibitory effects of small interfering RNA targeting c-myc in combination with 5-fluorouracil on the growth in vitro and in vivo -RSB- .
11131650	0	5-fluorouracil	10,24	carcinoembryonic_antigen	28,52	5-fluorouracil	carcinoembryonic antigen	MESH:D005472	1084	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effect of 5-fluorouracil on carcinoembryonic_antigen expression and shedding at clonal level in colon_cancer cells .
18577244	0	5-fluorouracil	20,34	carcinoembryonic_antigen	86,110	5-fluorouracil	carcinoembryonic antigen	MESH:D005472	1084	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|nmod|END_ENTITY	Combined effects of 5-fluorouracil , folinic_acid and oxaliplatin on the expression of carcinoembryonic_antigen in human colon_cancer cells : pharmacological basis to develop an active antitumor immunochemotherapy .
8968385	0	5-fluorouracil	93,107	carcinoembryonic_antigen	24,48	5-fluorouracil	carcinoembryonic antigen	MESH:D005472	1084	Chemical	Gene	effect|nmod|START_ENTITY changes|dep|effect changes|nmod|expression expression|compound|END_ENTITY	Drug-induced changes of carcinoembryonic_antigen expression in human cancer cells : effect of 5-fluorouracil .
9796980	0	5-fluorouracil	38,52	carcinoembryonic_antigen	90,114	5-fluorouracil	carcinoembryonic antigen	MESH:D005472	1084	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of the combined treatment with 5-fluorouracil , gamma-interferon or folinic_acid on carcinoembryonic_antigen expression in colon_cancer cells .
16445595	0	5-fluorouracil	21,35	cytochrome_P450_2C9	39,58	5-fluorouracil	cytochrome P450 2C9	MESH:D005472	1559	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|amod|END_ENTITY	Inhibitory effect of 5-fluorouracil on cytochrome_P450_2C9 activity in cancer patients .
3972814	0	5-fluorouracil	11,25	dihydrofolate_reductase	29,52	5-fluorouracil	dihydrofolate reductase	MESH:D005472	1719	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|mRNA mRNA|amod|END_ENTITY	Effects of 5-fluorouracil on dihydrofolate_reductase and dihydrofolate_reductase mRNA from methotrexate-resistant KB cells .
10778957	0	5-fluorouracil	32,46	dihydropyrimidine_dehydrogenase	82,113	5-fluorouracil	dihydropyrimidine dehydrogenase	MESH:D005472	1806	Chemical	Gene	responding|nmod|START_ENTITY Colorectal_tumors|acl|responding have|nsubj|Colorectal_tumors have|dobj|levels levels|acl|END_ENTITY	Colorectal_tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine_dehydrogenase , thymidylate_synthase , and thymidine_phosphorylase .
11350878	0	5-fluorouracil	117,131	dihydropyrimidine_dehydrogenase	44,75	5-fluorouracil	dihydropyrimidine dehydrogenase	MESH:D005472	1806	Chemical	Gene	administration|nmod|START_ENTITY deficiency|nmod|administration deficiency|amod|END_ENTITY	Lethal outcome of a patient with a complete dihydropyrimidine_dehydrogenase -LRB- DPD -RRB- deficiency after administration of 5-fluorouracil : frequency of the common IVS14 +1 G > A mutation causing DPD_deficiency .
11555593	0	5-fluorouracil	14,28	dihydropyrimidine_dehydrogenase	83,114	5-fluorouracil	dihydropyrimidine dehydrogenase	MESH:D005472	1806	Chemical	Gene	concentrations|compound|START_ENTITY Variations|nmod|concentrations Variations|acl|activities activities|amod|END_ENTITY	Variations in 5-fluorouracil concentrations of colorectal tissues as compared with dihydropyrimidine_dehydrogenase -LRB- DPD -RRB- enzyme activities and DPD messenger RNA levels .
11555601	0	5-fluorouracil	157,171	dihydropyrimidine_dehydrogenase	45,76	5-fluorouracil	dihydropyrimidine dehydrogenase	MESH:D005472	1806	Chemical	Gene	patients|nmod|START_ENTITY intron|nmod|patients site|nmod|intron Prevalence|dep|site Prevalence|nmod|mutation mutation|nmod|gene gene|amod|END_ENTITY	Prevalence of a common point mutation in the dihydropyrimidine_dehydrogenase -LRB- DPD -RRB- gene within the 5 ' - splice donor site of intron 14 in patients with severe 5-fluorouracil -LRB- 5-FU -RRB- - related toxicity compared with controls .
12484051	0	5-fluorouracil	68,82	dihydropyrimidine_dehydrogenase	150,181	5-fluorouracil	dihydropyrimidine dehydrogenase	MESH:D005472	1806	Chemical	Gene	infusion|nmod|START_ENTITY recurrence|nmod|infusion recurrence|dep|correlation correlation|nmod|expression expression|nmod|END_ENTITY	-LSB- Hepatic recurrence after prophylactic hepatic arterial infusion of 5-fluorouracil for Dukes ' _ C colorectal_cancer -- correlation with the expression of dihydropyrimidine_dehydrogenase in the primary_tumor -RSB- .
12929570	0	5-fluorouracil	108,122	dihydropyrimidine_dehydrogenase	39,70	5-fluorouracil	dihydropyrimidine dehydrogenase	MESH:D005472	81656(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Parenteral nutrition decreases hepatic dihydropyrimidine_dehydrogenase activity and modulates catabolism of 5-fluorouracil in rats .
15222105	0	5-fluorouracil	68,82	dihydropyrimidine_dehydrogenase	9,40	5-fluorouracil	dihydropyrimidine dehydrogenase	MESH:D005472	1806	Chemical	Gene	expression|nmod|START_ENTITY END_ENTITY|dobj|expression	-LSB- Tumoral dihydropyrimidine_dehydrogenase expression and efficacy of 5-fluorouracil plus leucovorin plus UFT therapy in patients with colorectal_cancer -RSB- .
15224198	0	5-fluorouracil	131,145	dihydropyrimidine_dehydrogenase	71,102	5-fluorouracil	dihydropyrimidine dehydrogenase	MESH:D005472	99586(Tax:10090)	Chemical	Gene	administration|nmod|START_ENTITY END_ENTITY|nmod|administration	Changes in thymidylate_synthase and its inhibition rate and changes in dihydropyrimidine_dehydrogenase after the administration of 5-fluorouracil with cisplatin to nude_mice with gastric_cancer xenograft SC-1-NU .
15271097	0	5-fluorouracil	77,91	dihydropyrimidine_dehydrogenase	164,195	5-fluorouracil	dihydropyrimidine dehydrogenase	MESH:D005472	1806	Chemical	Gene	method|nmod|START_ENTITY assay|nsubj|method assay|nmod|detection detection|nmod|patients patients|nmod|activity activity|compound|END_ENTITY	A simple and rapid high-performance liquid chromatographic -LRB- HPLC -RRB- method for 5-fluorouracil -LRB- 5-FU -RRB- assay in plasma and possible detection of patients with impaired dihydropyrimidine_dehydrogenase -LRB- DPD -RRB- activity .
15492566	0	5-fluorouracil	69,83	dihydropyrimidine_dehydrogenase	25,56	5-fluorouracil	dihydropyrimidine dehydrogenase	MESH:D005472	1806	Chemical	Gene	liver|compound|START_ENTITY END_ENTITY|nmod|liver	Clinical significance of dihydropyrimidine_dehydrogenase in adjuvant 5-fluorouracil liver perfusion chemotherapy for pancreatic_cancer .
15591715	0	5-fluorouracil	30,44	dihydropyrimidine_dehydrogenase	83,114	5-fluorouracil	dihydropyrimidine dehydrogenase	MESH:D005472	1806	Chemical	Gene	chemotherapy|compound|START_ENTITY chemotherapy|nmod|patient patient|nmod|variant variant|amod|END_ENTITY	Multiple_organ_failure due to 5-fluorouracil chemotherapy in a patient with a rare dihydropyrimidine_dehydrogenase gene variant .
15698412	0	5-fluorouracil	63,77	dihydropyrimidine_dehydrogenase	124,155	5-fluorouracil	dihydropyrimidine dehydrogenase	MESH:D005472	1806	Chemical	Gene	effect|nmod|START_ENTITY enhances|dobj|effect enhances|nmod|cells cells|nmod|downregulation downregulation|nmod|expression expression|amod|END_ENTITY	Consensus interferon enhances the anti-proliferative effect of 5-fluorouracil on human hepatoma cells via downregulation of dihydropyrimidine_dehydrogenase expression .
15820075	0	5-fluorouracil	91,105	dihydropyrimidine_dehydrogenase	32,63	5-fluorouracil	dihydropyrimidine dehydrogenase	MESH:D005472	1806	Chemical	Gene	concentration|nmod|START_ENTITY concentration|compound|END_ENTITY	-LSB- Relationship of serum level of dihydropyrimidine_dehydrogenase and serum concentration of 5-fluorouracil to treatment response and adverse events in colorectal_cancer patients -RSB- .
16021908	0	5-fluorouracil	153,167	dihydropyrimidine_dehydrogenase	54,85	5-fluorouracil	dihydropyrimidine dehydrogenase	MESH:D005472	1806	Chemical	Gene	effects|nmod|START_ENTITY related|nmod|effects related|nsubj|analysis analysis|nmod|5 5|dep|regions regions|nmod|gene gene|compound|END_ENTITY	Sequence analysis of the 5 ' - flanking regions of human dihydropyrimidine_dehydrogenase gene : identification of a new polymorphism related with effects of 5-fluorouracil .
16761622	0	5-fluorouracil	163,177	dihydropyrimidine_dehydrogenase	81,112	5-fluorouracil	dihydropyrimidine dehydrogenase	MESH:D005472	1806	Chemical	Gene	cells|nmod|START_ENTITY activity|nmod|cells activity|amod|END_ENTITY	Plasma level of a 5-fluorouracil metabolite , fluoro-beta-alanine correlates with dihydropyrimidine_dehydrogenase activity of peripheral blood mononuclear cells in 5-fluorouracil treated patients .
16761622	0	5-fluorouracil	18,32	dihydropyrimidine_dehydrogenase	81,112	5-fluorouracil	dihydropyrimidine dehydrogenase	MESH:D005472	1806	Chemical	Gene	metabolite|compound|START_ENTITY metabolite|appos|correlates correlates|nmod|activity activity|amod|END_ENTITY	Plasma level of a 5-fluorouracil metabolite , fluoro-beta-alanine correlates with dihydropyrimidine_dehydrogenase activity of peripheral blood mononuclear cells in 5-fluorouracil treated patients .
17046731	0	5-fluorouracil	124,138	dihydropyrimidine_dehydrogenase	42,73	5-fluorouracil	dihydropyrimidine dehydrogenase	MESH:D005472	1806	Chemical	Gene	administration|compound|START_ENTITY Identification|nmod|administration Identification|nmod|gene gene|amod|END_ENTITY	Identification of a novel mutation in the dihydropyrimidine_dehydrogenase gene in a patient with a lethal outcome following 5-fluorouracil administration and the determination of its frequency in a population of 500 patients with colorectal_carcinoma .
18600532	0	5-fluorouracil	104,118	dihydropyrimidine_dehydrogenase	8,39	5-fluorouracil	dihydropyrimidine dehydrogenase	MESH:D005472	1806	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|activity activity|compound|END_ENTITY	Altered dihydropyrimidine_dehydrogenase activity associated with mild toxicity in patients treated with 5-fluorouracil containing chemotherapy .
18620897	0	5-fluorouracil	72,86	dihydropyrimidine_dehydrogenase	12,43	5-fluorouracil	dihydropyrimidine dehydrogenase	MESH:D005472	1806	Chemical	Gene	role|nmod|START_ENTITY role|nmod|expression expression|amod|END_ENTITY	The role of dihydropyrimidine_dehydrogenase expression in resistance to 5-fluorouracil in head_and_neck_squamous_cell_carcinoma cells .
19287123	0	5-fluorouracil	18,32	dihydropyrimidine_dehydrogenase	110,141	5-fluorouracil	dihydropyrimidine dehydrogenase	MESH:D005472	1806	Chemical	Gene	Cardiotoxicity|nmod|START_ENTITY Cardiotoxicity|nmod|mutation mutation|nmod|gene gene|amod|END_ENTITY	Cardiotoxicity of 5-fluorouracil and capecitabine in a pancreatic_cancer patient with a novel mutation in the dihydropyrimidine_dehydrogenase gene .
19830428	0	5-fluorouracil	9,23	dihydropyrimidine_dehydrogenase	183,214	5-fluorouracil	dihydropyrimidine dehydrogenase	MESH:D005472	1806	Chemical	Gene	cytotoxicity|compound|START_ENTITY induced|nsubj|cytotoxicity induced|nmod|drugs drugs|nmod|downregulation downregulation|nmod|END_ENTITY	Enhanced 5-fluorouracil cytotoxicity in high cyclooxygenase-2 expressing colorectal_cancer cells and xenografts induced by non-steroidal anti-inflammatory drugs via downregulation of dihydropyrimidine_dehydrogenase .
20037380	0	5-fluorouracil	202,216	dihydropyrimidine_dehydrogenase	15,46	5-fluorouracil	dihydropyrimidine dehydrogenase	MESH:D005472	1806	Chemical	Gene	-RSB-|compound|START_ENTITY relationship|nmod|-RSB- Expression|dep|relationship Expression|nmod|END_ENTITY	-LSB- Expression of dihydropyrimidine_dehydrogenase in primary colorectal_cancer and liver metastasis -- a relationship between mRNA levels in cancer cells and protein levels in cancerous tissue and effect of 5-fluorouracil -RSB- .
20819423	0	5-fluorouracil	142,156	dihydropyrimidine_dehydrogenase	16,47	5-fluorouracil	dihydropyrimidine dehydrogenase	MESH:D005472	1806	Chemical	Gene	toxicity|nmod|START_ENTITY predict|dobj|toxicity predict|nsubj|Variants Variants|nmod|genes genes|amod|END_ENTITY	Variants in the dihydropyrimidine_dehydrogenase , methylenetetrahydrofolate_reductase and thymidylate synthase genes predict early toxicity of 5-fluorouracil in colorectal_cancer patients .
21107571	0	5-fluorouracil	17,31	dihydropyrimidine_dehydrogenase	146,177	5-fluorouracil	dihydropyrimidine dehydrogenase	MESH:D005472	1806	Chemical	Gene	levels|compound|START_ENTITY levels|acl|using using|dobj|method method|nmod|evaluation evaluation|nmod|activity activity|amod|END_ENTITY	Determination of 5-fluorouracil and dihydrofluorouracil levels by using a liquid chromatography-tandem mass spectrometry method for evaluation of dihydropyrimidine_dehydrogenase enzyme activity .
22199347	0	5-fluorouracil	121,135	dihydropyrimidine_dehydrogenase	4,35	5-fluorouracil	dihydropyrimidine dehydrogenase	MESH:D005472	1806	Chemical	Gene	treated|nmod|START_ENTITY correlates|acl|treated correlates|compound|END_ENTITY	Low dihydropyrimidine_dehydrogenase correlates with prolonged survival in patients with lung_adenocarcinoma treated with 5-fluorouracil .
2293556	0	5-fluorouracil	204,218	dihydropyrimidine_dehydrogenase	21,52	5-fluorouracil	dihydropyrimidine dehydrogenase	MESH:D005472	1806	Chemical	Gene	receiving|dobj|START_ENTITY patients|acl|receiving Relationship|nmod|patients Relationship|nmod|activity activity|amod|END_ENTITY	Relationship between dihydropyrimidine_dehydrogenase activity and plasma 5-fluorouracil levels with evidence for circadian variation of enzyme activity and plasma drug levels in cancer patients receiving 5-fluorouracil by protracted continuous infusion .
23313143	0	5-fluorouracil	99,113	dihydropyrimidine_dehydrogenase	20,51	5-fluorouracil	dihydropyrimidine dehydrogenase	MESH:D005472	99586(Tax:10090)	Chemical	Gene	resistance|nmod|START_ENTITY involved|nmod|resistance involved|nsubjpass|upregulation upregulation|nmod|END_ENTITY	The upregulation of dihydropyrimidine_dehydrogenase in liver is involved in acquired resistance to 5-fluorouracil .
23942539	0	5-fluorouracil	72,86	dihydropyrimidine_dehydrogenase	13,44	5-fluorouracil	Dihydropyrimidine dehydrogenase	MESH:D005472	1806	Chemical	Gene	therapy|compound|START_ENTITY personalizing|dobj|therapy genotypes|advcl|personalizing genotypes|nsubj|Potential Potential|nmod|END_ENTITY	Potential of dihydropyrimidine_dehydrogenase genotypes in personalizing 5-fluorouracil therapy among colorectal_cancer patients .
24405586	0	5-fluorouracil	208,222	dihydropyrimidine_dehydrogenase	19,50	5-fluorouracil	dihydropyrimidine dehydrogenase	MESH:D005472	1806	Chemical	Gene	using|dobj|START_ENTITY small-cell_lung_cancer|acl|using mutations|dep|small-cell_lung_cancer associated|nmod|mutations associated|nsubjpass|expression expression|nmod|END_ENTITY	High expression of dihydropyrimidine_dehydrogenase in lung adenocarcinoma is associated with mutations in epidermal_growth_factor receptor : implications for the treatment of non -- small-cell_lung_cancer using 5-fluorouracil .
26623034	0	5-fluorouracil	37,51	dihydropyrimidine_dehydrogenase	66,97	5-fluorouracil	dihydropyrimidine dehydrogenase	MESH:D005472	1806	Chemical	Gene	toxicity|compound|START_ENTITY toxicity|nmod|polymorphisms polymorphisms|amod|END_ENTITY	Association and prediction of severe 5-fluorouracil toxicity with dihydropyrimidine_dehydrogenase gene polymorphisms : A meta-analysis .
4053028	0	5-fluorouracil	55,69	dihydropyrimidine_dehydrogenase	104,135	5-fluorouracil	dihydropyrimidine dehydrogenase	MESH:D005472	81656(Tax:10116)	Chemical	Gene	degradation|nmod|START_ENTITY uridine|nmod|degradation Effects|acl|uridine END_ENTITY|nsubj|Effects	Effects of uridine and thymidine on the degradation of 5-fluorouracil , uracil , and thymine by rat liver dihydropyrimidine_dehydrogenase .
8083224	0	5-fluorouracil	104,118	dihydropyrimidine_dehydrogenase	45,76	5-fluorouracil	dihydropyrimidine dehydrogenase	MESH:D005472	1806	Chemical	Gene	toxicity|compound|START_ENTITY associated|nmod|toxicity associated|nsubj|cloning cloning|nmod|END_ENTITY	cDNA cloning and chromosome mapping of human dihydropyrimidine_dehydrogenase , an enzyme associated with 5-fluorouracil toxicity and congenital_thymine_uraciluria .
8857547	0	5-fluorouracil	29,43	dihydropyrimidine_dehydrogenase	55,86	5-fluorouracil	dihydropyrimidine dehydrogenase	MESH:D005472	1806	Chemical	Gene	therapy|nmod|START_ENTITY therapy|acl|related related|xcomp|END_ENTITY	Individualizing therapy with 5-fluorouracil related to dihydropyrimidine_dehydrogenase : theory and limits .
9865912	0	5-fluorouracil	105,119	dihydropyrimidine_dehydrogenase	41,72	5-fluorouracil	dihydropyrimidine dehydrogenase	MESH:D005472	1806	Chemical	Gene	toxicity|compound|START_ENTITY patient|nmod|toxicity gene|nmod|patient gene|amod|END_ENTITY	Identification of novel mutations in the dihydropyrimidine_dehydrogenase gene in a Japanese patient with 5-fluorouracil toxicity .
12759532	0	5-fluorouracil	98,112	granulocyte-macrophage_colony-stimulating_factor	13,61	5-fluorouracil	granulocyte-macrophage colony-stimulating factor	MESH:D005472	1437	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|END_ENTITY	Subcutaneous granulocyte-macrophage_colony-stimulating_factor in mucositis induced by an adjuvant 5-fluorouracil plus leucovorin regimen .
15975592	0	5-fluorouracil	114,128	granulocyte_macrophage-colony_stimulating_factor	14,62	5-fluorouracil	granulocyte macrophage-colony stimulating factor	MESH:D005472	116630(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of granulocyte_macrophage-colony_stimulating_factor on bacterial translocation after administration of 5-fluorouracil in rats .
18567802	0	5-fluorouracil	48,62	hRrp6	26,31	5-fluorouracil	hRrp6	MESH:D005472	5394	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	The RNA exosome component hRrp6 is a target for 5-fluorouracil in human cells .
15232686	1	5-fluorouracil	197,211	interferon-alpha-2a	124,143	5-fluorouracil	interferon-alpha-2a	MESH:D005472	3440	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|amod|END_ENTITY	A retrospective study comparing interferon-alpha-2a / vinblastine versus interferon-alpha-2a / interleukin-2 / 5-fluorouracil -RSB- .
17919232	0	5-fluorouracil	114,128	interferon-alpha-2b	31,50	5-fluorouracil	interferon-alpha-2b	MESH:D005472	3440	Chemical	Gene	combined|nmod|START_ENTITY interferon-alpha|advcl|combined interferon-alpha|nsubj|effects effects|nmod|recombinant recombinant|amod|END_ENTITY	Similar effects of recombinant interferon-alpha-2b and natural interferon-alpha when combined with intra-arterial 5-fluorouracil for the treatment of advanced_hepatocellular_carcinoma .
8149941	0	5-fluorouracil	82,96	interferon-alpha-2b	32,51	5-fluorouracil	interferon-alpha-2b	MESH:D005472	3440	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|levels levels|amod|END_ENTITY	Influence of different doses of interferon-alpha-2b on the blood plasma levels of 5-fluorouracil .
8374869	0	5-fluorouracil	33,47	interferon-alpha-2b	95,114	5-fluorouracil	interferon-alpha-2b	MESH:D005472	3440	Chemical	Gene	infusion|nmod|START_ENTITY infusion|nmod|END_ENTITY	Continuous infusion of high-dose 5-fluorouracil in combination with leucovorin and recombinant interferon-alpha-2b in patients with advanced colorectal_cancer .
8558676	0	5-fluorouracil	0,14	interferon-alpha_2b	57,76	5-fluorouracil	interferon-alpha 2b	MESH:D005472	3440	Chemical	Gene	START_ENTITY|acl|combined combined|nmod|END_ENTITY	5-fluorouracil and allopurinol combined with recombinant interferon-alpha_2b in the treatment of patients with advanced_prostate_cancer : a phase I/II study .
6436183	0	5-fluorouracil	62,76	interferon-gamma	22,38	5-fluorouracil	interferon-gamma	MESH:D005472	3458	Chemical	Gene	activity|nmod|START_ENTITY activity|nmod|END_ENTITY	Cytolytic activity of interferon-gamma and its synergism with 5-fluorouracil .
1498068	0	5-fluorouracil	33,47	interferon_alpha_2b	82,101	5-fluorouracil	interferon alpha 2b	MESH:D005472	3440	Chemical	Gene	modulation|nmod|START_ENTITY modulation|nmod|END_ENTITY	Double biochemical modulation of 5-fluorouracil by leucovorin and cyclic low dose interferon_alpha_2b in advanced colorectal_cancer patients .
11936589	0	5-fluorouracil	13,27	interleukin-18	48,62	5-fluorouracil	interleukin-18	MESH:D005472	3606	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|production production|amod|END_ENTITY	Influence of 5-fluorouracil and folinic_acid on interleukin-18 production in colorectal_cancer patients .
9238541	0	5-fluorouracil	10,24	interleukin-1_and_interleukin-2_receptor	28,68	5-fluorouracil	interleukin-1 and interleukin-2 receptor	MESH:D005472	3552	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of 5-fluorouracil on interleukin-1_and_interleukin-2_receptor expression .
1520312	0	5-fluorouracil	10,24	interleukin-2	28,41	5-fluorouracil	interleukin-2	MESH:D005472	116562(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of 5-fluorouracil on interleukin-2 expression .
7695972	0	5-fluorouracil	85,99	interleukin-2	33,46	5-fluorouracil	interleukin-2	MESH:D005472	3558	Chemical	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	A phase III study of recombinant interleukin-2 , 5-fluorouracil and leucovorin versus 5-fluorouracil and leucovorin in patients with unresectable or metastatic colorectal_carcinoma .
25482885	0	5-fluorouracil	37,51	miR-203	0,7	5-fluorouracil	miR-203	MESH:D005472	406986	Chemical	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	miR-203 enhances chemosensitivity to 5-fluorouracil by targeting thymidylate_synthase in colorectal_cancer .
20647341	0	5-fluorouracil	26,40	miR-215	8,15	5-fluorouracil	miR-215	MESH:D005472	406997	Chemical	Gene	resistance|compound|START_ENTITY resistance|amod|END_ENTITY	miR-192 / miR-215 influence 5-fluorouracil resistance through cell cycle-mediated mechanisms complementary to its post-transcriptional thymidilate synthase regulation .
25544773	0	5-fluorouracil	38,52	microRNA-21	14,25	5-fluorouracil	microRNA-21	MESH:D005472	406991	Chemical	Gene	axis|nmod|START_ENTITY axis|csubj|Targeting Targeting|dobj|AP1 AP1|amod|END_ENTITY	Targeting the microRNA-21 / AP1 axis by 5-fluorouracil and pirarubicin in human hepatocellular_carcinoma .
26418978	0	5-fluorouracil	42,56	microRNA-21	69,80	5-fluorouracil	microRNA-21	MESH:D005472	406991	Chemical	Gene	cells|nmod|START_ENTITY resistance|nmod|cells mediated|nsubj|resistance mediated|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Drug resistance of colon_cancer cells to 5-fluorouracil mediated by microRNA-21 -RSB- .
25502560	0	5-fluorouracil	38,52	microRNA-96	56,67	5-fluorouracil	microRNA-96	MESH:D005472	407053	Chemical	Gene	modulation|nmod|START_ENTITY modulation|nmod|END_ENTITY	Indirect modulation of sensitivity to 5-fluorouracil by microRNA-96 in human colorectal_cancer cells .
15050369	0	5-fluorouracil	90,104	mucin	13,18	5-fluorouracil	mucin	MESH:D005472	100508689	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Differential mucin expression in colon_carcinoma HT-29 clones with variable resistance to 5-fluorouracil and methotrexate .
10785598	0	5-fluorouracil	139,153	p53	90,93	5-fluorouracil	p53	MESH:D005472	7157	Chemical	Gene	treatment|nmod|START_ENTITY colon_cancer|nmod|treatment colon_cancer|nsubj|events events|nmod|thymidylate_synthase thymidylate_synthase|nmod|END_ENTITY	Molecular downstream events and induction of thymidylate_synthase in mutant and wild-type p53 colon_cancer cell lines after treatment with 5-fluorouracil and the thymidylate_synthase inhibitor raltitrexed .
11044365	0	5-fluorouracil	33,47	p53	77,80	5-fluorouracil	p53	MESH:D005472	7157	Chemical	Gene	sensitivity|compound|START_ENTITY sensitivity|nmod|status status|compound|END_ENTITY	Bcl-2 / Bax protein ratio predicts 5-fluorouracil sensitivity independently of p53 status .
11445854	0	5-fluorouracil	49,63	p53	104,107	5-fluorouracil	p53	MESH:D005472	7157	Chemical	Gene	inductions|nmod|START_ENTITY inductions|nmod|mutation mutation|compound|END_ENTITY	Apoptosis and thymidylate_synthase inductions by 5-fluorouracil in gastric_cancer cells with or without p53 mutation .
11752120	0	5-fluorouracil	85,99	p53	109,112	5-fluorouracil	p53	MESH:D005472	7157	Chemical	Gene	increases|nmod|START_ENTITY increases|dep|role role|nmod|END_ENTITY	Nonpeptidomimetic farnesyltransferase inhibitor RPR-115135 increases cytotoxicity of 5-fluorouracil : role of p53 .
12096336	0	5-fluorouracil	115,129	p53	35,38	5-fluorouracil	p53	MESH:D005472	7157	Chemical	Gene	leading|nmod|START_ENTITY expression|acl|leading activation|nmod|expression gain|dep|activation gain|nmod|activity activity|nmod|mutants mutants|compound|END_ENTITY	Novel gain of function activity of p53 mutants : activation of the dUTPase gene expression leading to resistance to 5-fluorouracil .
12530065	0	5-fluorouracil	119,133	p53	22,25	5-fluorouracil	p53	MESH:D005472	7157	Chemical	Gene	sensitizes|nmod|START_ENTITY sensitizes|nsubj|expression expression|nmod|END_ENTITY	Reduced expression of p53 and p21WAF1/CIP1 sensitizes human breast_cancer cells to paclitaxel and its combination with 5-fluorouracil .
12935400	0	5-fluorouracil	51,65	p53	23,26	5-fluorouracil	p53	MESH:D005472	7157	Chemical	Gene	upregulation|nmod|START_ENTITY upregulation|nmod|effects effects|compound|END_ENTITY	p14ARF upregulation of p53 and enhanced effects of 5-fluorouracil in pancreatic_cancer .
15010816	0	5-fluorouracil	60,74	p53	14,17	5-fluorouracil	p53	MESH:D005472	7157	Chemical	Gene	chemotherapy|compound|START_ENTITY Expression|nmod|chemotherapy Expression|nmod|protein protein|compound|END_ENTITY	Expression of p53 protein as a predictor of the response to 5-fluorouracil and cisplatin chemotherapy in human gastrointestinal_cancer cell lines evaluated with apoptosis by use of thin layer collagen gel .
15041737	0	5-fluorouracil	94,108	p53	20,23	5-fluorouracil	p53	MESH:D005472	7157	Chemical	Gene	resistant|nmod|START_ENTITY Characterization|amod|resistant Characterization|nmod|lines lines|nummod|END_ENTITY	Characterization of p53 wild-type and null isogenic colorectal_cancer cell lines resistant to 5-fluorouracil , oxaliplatin , and irinotecan .
15534911	0	5-fluorouracil	53,67	p53	46,49	5-fluorouracil	p53	MESH:D005472	301300(Tax:10116)	Chemical	Gene	expressing|nmod|START_ENTITY expressing|dobj|END_ENTITY	The effect of adenovirus expressing wild-type p53 on 5-fluorouracil chemosensitivity is related to p53 status in pancreatic_cancer cell lines .
15534911	0	5-fluorouracil	53,67	p53	99,102	5-fluorouracil	p53	MESH:D005472	301300(Tax:10116)	Chemical	Gene	expressing|nmod|START_ENTITY adenovirus|acl|expressing effect|nmod|adenovirus related|nsubjpass|effect related|nmod|status status|compound|END_ENTITY	The effect of adenovirus expressing wild-type p53 on 5-fluorouracil chemosensitivity is related to p53 status in pancreatic_cancer cell lines .
15870870	0	5-fluorouracil	21,35	p53	82,85	5-fluorouracil	p53	MESH:D005472	7157	Chemical	Gene	induced|nmod|START_ENTITY Apoptosis|acl|induced associated|nsubjpass|Apoptosis associated|nmod|status status|compound|END_ENTITY	Apoptosis induced by 5-fluorouracil , cisplatin and paclitaxel are associated with p53 gene status in gastric_cancer cell lines .
17242401	0	5-fluorouracil	0,14	p53	29,32	5-fluorouracil	p53	MESH:D005472	7157	Chemical	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	5-fluorouracil activation of p53 involves an MDM2-ribosomal protein interaction .
17634554	0	5-fluorouracil	44,58	p53	14,17	5-fluorouracil	p53	MESH:D005472	7157	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of p53 expression in response to 5-fluorouracil in human cancer RKO cells .
17725105	0	5-fluorouracil	35,49	p53	68,71	5-fluorouracil	p53	MESH:D005472	7157	Chemical	Gene	cytotoxicity|nmod|START_ENTITY cytotoxicity|nmod|colon_cancer colon_cancer|compound|END_ENTITY	Schedule-dependent cytotoxicity of 5-fluorouracil and irinotecan in p53 mutant human colon_cancer .
18600534	0	5-fluorouracil	80,94	p53	39,42	5-fluorouracil	p53	MESH:D005472	7157	Chemical	Gene	affect|nmod|START_ENTITY affect|nsubj|inactivity inactivity|nmod|END_ENTITY	Functional inactivity and mutations of p53 differentially affect sensitivity to 5-fluorouracil and antifolate inhibitors of thymidylate_synthase -LRB- TS -RRB- by altering TS levels in colorectal_cancer cells .
19810096	0	5-fluorouracil	96,110	p53	15,18	5-fluorouracil	p53	MESH:D005472	7157	Chemical	Gene	predicts|nmod|START_ENTITY codon|ccomp|predicts codon|nsubj|Combination Combination|nmod|END_ENTITY	Combination of p53 codon 72 polymorphism and inactive p53 mutation predicts chemosensitivity to 5-fluorouracil in colorectal_cancer .
19833818	0	5-fluorouracil	127,141	p53	10,13	5-fluorouracil	p53	MESH:D005472	7157	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|Impact Impact|nmod|expression expression|compound|END_ENTITY	Impact of p53 expression and microsatellite_instability on stage_III_colon_cancer disease-free survival in patients treated by 5-fluorouracil and leucovorin with or without oxaliplatin .
19923910	0	5-fluorouracil	19,33	p53	39,42	5-fluorouracil	p53	MESH:D005472	7157	Chemical	Gene	START_ENTITY|nmod|restoration restoration|compound|END_ENTITY	The combination of 5-fluorouracil plus p53 pathway restoration is associated with depletion of p53-deficient or mutant p53-expressing putative colon_cancer stem cells .
22192357	0	5-fluorouracil	63,77	p53	23,26	5-fluorouracil	p53	MESH:D005472	7157	Chemical	Gene	mediates|nmod|START_ENTITY mediates|nsubj|regulation regulation|nmod|END_ENTITY	14-3-3 regulation by p53 mediates a chemotherapy response to 5-fluorouracil in MCF-7 breast_cancer cells via Akt inactivation .
24277474	0	5-fluorouracil	116,130	p53	46,49	5-fluorouracil	p53	MESH:D005472	7157	Chemical	Gene	benefit|nmod|START_ENTITY patients|acl:relcl|benefit identify|dobj|patients identify|nsubj|phenotype phenotype|compound|END_ENTITY	Thymidylate synthase expression and p21 -LRB- WAF1 -RRB- / p53 phenotype of colon_cancers identify patients who may benefit from 5-fluorouracil based therapy .
8608838	0	5-fluorouracil	56,70	p53	0,3	5-fluorouracil	p53	MESH:D005472	7157	Chemical	Gene	chemotherapy|compound|START_ENTITY protein|nmod|chemotherapy protein|nsubj|END_ENTITY	p53 protein overexpression and response to biomodulated 5-fluorouracil chemotherapy in patients with advanced colorectal_cancer .
9392545	0	5-fluorouracil	146,160	p53	9,12	5-fluorouracil	p53	MESH:D005472	7157	Chemical	Gene	treated|nmod|START_ENTITY patients|acl|treated response|nmod|patients predicts|nmod|response predicts|nsubj|status status|compound|END_ENTITY	Original p53 status predicts for pathological response in locally advanced breast_cancer patients treated preoperatively with continuous infusion 5-fluorouracil and radiation therapy .
9930367	0	5-fluorouracil	79,93	p53	0,3	5-fluorouracil	p53	MESH:D005472	7157	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|apoptosis apoptosis|amod|END_ENTITY	p53 - and p21-independent apoptosis of squamous_cell_carcinoma cells induced by 5-fluorouracil and radiation .
7954335	2	5-fluorouracil	97,111	paf_acetylhydrolase	53,72	5-fluorouracil	paf acetylhydrolase	MESH:D005472	7941	Chemical	Gene	infusion|nmod|START_ENTITY END_ENTITY|nmod|infusion	Elevated levels of plasma paf_acetylhydrolase after rapid infusion of 5-fluorouracil in cancer patients .
8790139	0	5-fluorouracil	103,117	platelet_factor_4	18,35	5-fluorouracil	platelet factor 4	MESH:D005472	56744(Tax:10090)	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|effect effect|nmod|END_ENTITY	In vivo effect of platelet_factor_4 -LRB- PF4 -RRB- and tetrapeptide AcSDKP on haemopoiesis of mice treated with 5-fluorouracil .
10412941	0	5-fluorouracil	17,31	thymidine_phosphorylase	118,141	5-fluorouracil	thymidine phosphorylase	MESH:D005472	1890	Chemical	Gene	Biomodulation|nmod|START_ENTITY Biomodulation|dep|relationship relationship|nmod|expression expression|nmod|END_ENTITY	Biomodulation of 5-fluorouracil by interferon-alpha in human renal_carcinoma cells : relationship to the expression of thymidine_phosphorylase .
10468288	0	5-fluorouracil	47,61	thymidine_phosphorylase	140,163	5-fluorouracil	thymidine phosphorylase	MESH:D005472	1890	Chemical	Gene	cytotoxicity|nmod|START_ENTITY transfected|nsubj|cytotoxicity transfected|nmod|END_ENTITY	Increased cytotoxicity and bystander effect of 5-fluorouracil and 5-deoxy-5-fluorouridine in human colorectal_cancer cells transfected with thymidine_phosphorylase .
12467230	0	5-fluorouracil	97,111	thymidine_phosphorylase	15,38	5-fluorouracil	thymidine phosphorylase	MESH:D005472	1890	Chemical	Gene	activity|compound|START_ENTITY enhances|dobj|activity enhances|nsubj|Combination Combination|nmod|transfer transfer|amod|END_ENTITY	Combination of thymidine_phosphorylase gene transfer and deoxyinosine treatment greatly enhances 5-fluorouracil antitumor activity in vitro and in vivo .
25537222	0	5-fluorouracil	17,31	thymidine_phosphorylase	47,70	5-fluorouracil	thymidine phosphorylase	MESH:D005472	1890	Chemical	Gene	influence|nmod|START_ENTITY influence|nmod|END_ENTITY	The influence of 5-fluorouracil on activity of thymidine_phosphorylase in gastric_adenocarcinoma and normal adjacent tissue .
7627962	0	5-fluorouracil	111,125	thymidine_phosphorylase	182,205	5-fluorouracil	thymidine phosphorylase	MESH:D005472	1890	Chemical	Gene	activity|nmod|START_ENTITY potentiates|dobj|activity potentiates|advcl|used used|nmod|interferon interferon|appos|inducer inducer|nmod|expression expression|amod|END_ENTITY	5-Ethoxy-2 ' - deoxyuridine , a novel substrate for thymidine_phosphorylase , potentiates the antitumor activity of 5-fluorouracil when used in combination with interferon , an inducer of thymidine_phosphorylase expression .
7627962	0	5-fluorouracil	111,125	thymidine_phosphorylase	48,71	5-fluorouracil	thymidine phosphorylase	MESH:D005472	1890	Chemical	Gene	activity|nmod|START_ENTITY potentiates|dobj|activity potentiates|nsubj|deoxyuridine deoxyuridine|appos|substrate substrate|nmod|END_ENTITY	5-Ethoxy-2 ' - deoxyuridine , a novel substrate for thymidine_phosphorylase , potentiates the antitumor activity of 5-fluorouracil when used in combination with interferon , an inducer of thymidine_phosphorylase expression .
8137250	0	5-fluorouracil	42,56	thymidine_phosphorylase	178,201	5-fluorouracil	thymidine phosphorylase	MESH:D005472	1890	Chemical	Gene	activity|nmod|START_ENTITY Potentiation|nmod|activity results|nsubj|Potentiation results|nmod|effects effects|nmod|END_ENTITY	Potentiation of the antitumor activity of 5-fluorouracil in colon_carcinoma cells by the combination of interferon and deoxyribonucleosides results from complementary effects on thymidine_phosphorylase .
9796967	0	5-fluorouracil	165,179	thymidine_phosphorylase	36,59	5-fluorouracil	thymidine phosphorylase	MESH:D005472	1890	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|expression expression|nmod|END_ENTITY	High basal level gene expression of thymidine_phosphorylase -LRB- platelet-derived endothelial cell growth factor -RRB- in colorectal_tumors is associated with nonresponse to 5-fluorouracil .
14970324	0	5-fluorouracil	98,112	thymidylate_synthase	31,51	5-fluorouracil	thymidylate synthase	MESH:D005472	7298	Chemical	Gene	identifies|nmod|START_ENTITY identifies|dobj|amplification amplification|amod|END_ENTITY	Digital karyotyping identifies thymidylate_synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal_cancer patients .
1516048	0	5-fluorouracil	44,58	thymidylate_synthase	13,33	5-fluorouracil	thymidylate synthase	MESH:D005472	22171(Tax:10090)	Chemical	Gene	treatment|compound|START_ENTITY treatment|amod|END_ENTITY	Elevation of thymidylate_synthase following 5-fluorouracil treatment is prevented by the addition of leucovorin in murine colon_tumors .
19339911	0	5-fluorouracil	50,64	thymidylate_synthase	15,35	5-fluorouracil	thymidylate synthase	MESH:D005472	7298	Chemical	Gene	cytotoxicity|compound|START_ENTITY variants|nmod|cytotoxicity variants|nsubj|Association Association|nmod|END_ENTITY	Association of thymidylate_synthase variants with 5-fluorouracil cytotoxicity .
2064315	0	5-fluorouracil	140,154	thymidylate_synthase	75,95	5-fluorouracil	thymidylate synthase	MESH:D005472	22171(Tax:10090)	Chemical	Gene	concentrations|nmod|START_ENTITY END_ENTITY|dobj|concentrations	Relationship of in vivo antitumor activities of fluorinated pyrimidines to thymidylate_synthase activity and intratumoral concentrations of 5-fluorouracil and uracil .
23915286	0	5-fluorouracil	96,110	thymidylate_synthase	52,72	5-fluorouracil	thymidylate synthase	MESH:D005472	7298	Chemical	Gene	sensitivity|compound|START_ENTITY responsible|nmod|sensitivity END_ENTITY|amod|responsible	MicroRNA-433 negatively regulates the expression of thymidylate_synthase -LRB- TYMS -RRB- responsible for 5-fluorouracil sensitivity in HeLa cells .
2427493	0	5-fluorouracil	20,34	thymidylate_synthase	175,195	5-fluorouracil	thymidylate synthase	MESH:D005472	22171(Tax:10090)	Chemical	Gene	cytotoxicity|nmod|START_ENTITY due|nsubj|cytotoxicity due|advcl|evidenced evidenced|nmod|use use|nmod|deficient deficient|nmod|END_ENTITY	The cytotoxicity of 5-fluorouracil is due to its incorporation into RNA not its inhibition of thymidylate_synthase as evidenced by the use of a mouse cell mutant deficient in thymidylate_synthase .
2427493	0	5-fluorouracil	20,34	thymidylate_synthase	94,114	5-fluorouracil	thymidylate synthase	MESH:D005472	22171(Tax:10090)	Chemical	Gene	cytotoxicity|nmod|START_ENTITY due|nsubj|cytotoxicity due|nmod|incorporation incorporation|nmod|inhibition inhibition|nmod|END_ENTITY	The cytotoxicity of 5-fluorouracil is due to its incorporation into RNA not its inhibition of thymidylate_synthase as evidenced by the use of a mouse cell mutant deficient in thymidylate_synthase .
25482885	0	5-fluorouracil	37,51	thymidylate_synthase	65,85	5-fluorouracil	thymidylate synthase	MESH:D005472	7298	Chemical	Gene	enhances|nmod|START_ENTITY enhances|advcl|targeting targeting|dobj|END_ENTITY	miR-203 enhances chemosensitivity to 5-fluorouracil by targeting thymidylate_synthase in colorectal_cancer .
26416450	0	5-fluorouracil	23,37	thymidylate_synthase	73,93	5-fluorouracil	thymidylate synthase	MESH:D005472	7298	Chemical	Gene	Acquired|nmod|START_ENTITY Acquired|nmod|expression expression|amod|END_ENTITY	Acquired resistance to 5-fluorouracil via HSP90/Src-mediated increase in thymidylate_synthase expression in colon_cancer .
2698593	0	5-fluorouracil	11,25	thymidylate_synthase	29,49	5-fluorouracil	thymidylate synthase	MESH:D005472	22171(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effects of 5-fluorouracil on thymidylate_synthase activity and development of bone marrow grafts in spleens of irradiated mice .
3395138	0	5-fluorouracil	116,130	thymidylate_synthase	45,65	5-fluorouracil	thymidylate synthase	MESH:D005472	22171(Tax:10090)	Chemical	Gene	derivatives|compound|START_ENTITY activity|nmod|derivatives parameter|nmod|activity measuring|nmod|parameter measuring|dobj|inhibition inhibition|nmod|activity activity|amod|END_ENTITY	-LSB- The significance of measuring inhibition of thymidylate_synthase activity as a parameter for antitumor activity of 5-fluorouracil derivatives -RSB- .
3565050	0	5-fluorouracil	99,113	thymidylate_synthase	10,30	5-fluorouracil	thymidylate synthase	MESH:D005472	22171(Tax:10090)	Chemical	Gene	treated|nmod|START_ENTITY mice|acl|treated activity|nmod|mice activity|amod|END_ENTITY	Increased thymidylate_synthase activity in extracts of erythropoietic spleens of mice treated with 5-fluorouracil .
7577082	0	5-fluorouracil	100,114	thymidylate_synthase	48,68	5-fluorouracil	thymidylate synthase	MESH:D005472	22171(Tax:10090)	Chemical	Gene	administration|nmod|START_ENTITY END_ENTITY|nmod|administration	Antitumour activity , toxicity and inhibition of thymidylate_synthase of prolonged administration of 5-fluorouracil in mice .
10357907	0	5-fluorouracil	13,27	transforming_growth_factor-beta_1	65,98	5-fluorouracil	transforming growth factor-beta 1	MESH:D005472	59086(Tax:10116)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of 5-fluorouracil on colonic healing and expression of transforming_growth_factor-beta_1 .
1940339	0	5-fluorouracil	110,124	transforming_growth_factor-beta_1	23,56	5-fluorouracil	transforming growth factor-beta 1	MESH:D005472	21803(Tax:10090)	Chemical	Gene	mice|nmod|START_ENTITY Effects|nmod|mice Effects|nmod|END_ENTITY	Effects of recombinant transforming_growth_factor-beta_1 on hematologic recovery after treatment of mice with 5-fluorouracil .
6189586	0	5-formyltetrahydrofolate	138,162	dihydrofolate_reductase	111,134	5-formyltetrahydrofolate	dihydrofolate reductase	MESH:D002955	1719	Chemical	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	Role of methotrexate polyglutamylation and cellular energy metabolism in inhibition of methotrexate binding to dihydrofolate_reductase by 5-formyltetrahydrofolate in Ehrlich_ascites_tumor cells in vitro .
6707696	0	5-halopyrimidinones	11,30	cytochrome_P-450	84,100	5-halopyrimidinones	cytochrome P-450	null	13079(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of 5-halopyrimidinones with antiviral and antineoplastic activity on murine cytochrome_P-450 .
20873740	0	5-heteroaryl-3-carboxamido-2-aryl_pyrroles	24,66	Cdc7	0,4	5-heteroaryl-3-carboxamido-2-aryl pyrroles	Cdc7	null	8317	Chemical	Gene	inhibitors|dep|START_ENTITY inhibitors|amod|END_ENTITY	Cdc7 kinase inhibitors : 5-heteroaryl-3-carboxamido-2-aryl_pyrroles as potential antitumor agents .
12667691	0	5-heteroatom-substituted_pyridopyrimidines	50,92	adenosine_kinase	96,112	5-heteroatom-substituted pyridopyrimidines	adenosine kinase	null	25368(Tax:10116)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Synthesis and structure-activity relationships of 5-heteroatom-substituted_pyridopyrimidines as adenosine_kinase inhibitors .
18006464	8	5-hydroxydecanoate	1089,1107	K_ATP	1065,1070	5-hydroxydecanoate	HSP90	MESH:C052853	299331(Tax:10116)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	This protective effect was prevented by expression of dominant negative Kir6 .2 AAA , siRNA targeting Kir6 .2 , or the K_ATP channel inhibitor 5-hydroxydecanoate .
7686083	0	5-hydroxyindoleacetic_acid	29,55	Interleukin-1_beta	0,18	5-hydroxyindoleacetic acid	Interleukin-1 beta	CHEBI:27823	24494(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY increases|dobj|release increases|nsubj|END_ENTITY	Interleukin-1_beta increases 5-hydroxyindoleacetic_acid release in the hypothalamus in vivo .
22506404	0	5-hydroxymethyl_furfural	11,35	BCL-2	39,44	5-hydroxymethyl furfural	BCL-2	MESH:C008046	24224(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	-LSB- Effect of 5-hydroxymethyl_furfural on BCL-2 and NF-kappaB gene expression of apoptotic rat hippocampal neurons injured by H2O2 -RSB- .
25290267	0	5-hydroxymethylcytosine	9,32	Engrailed-2	40,51	5-hydroxymethylcytosine	Engrailed-2	MESH:C011865	2020	Chemical	Gene	START_ENTITY|nmod|promoter promoter|compound|END_ENTITY	Elevated 5-hydroxymethylcytosine in the Engrailed-2 -LRB- EN-2 -RRB- promoter is associated with increased gene expression and decreased MeCP2 binding in autism cerebellum .
11526119	0	5-hydroxymethyluracil	39,60	SMUG1	91,96	5-hydroxymethyluracil	SMUG1	MESH:C008055	23583	Chemical	Gene	activity|amod|START_ENTITY identification|nmod|activity identification|nmod|END_ENTITY	Definitive identification of mammalian 5-hydroxymethyluracil DNA N-glycosylase activity as SMUG1 .
11104831	0	5-hydroxytryptamine	80,99	5-HT1A	52,58	5-hydroxytryptamine	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY regulating|dobj|release receptors|acl|regulating receptors|nummod|END_ENTITY	Estimation of apparent pA2 values for WAY_100635 at 5-HT1A receptors regulating 5-hydroxytryptamine release in anaesthetised rats .
15140278	0	5-hydroxytryptamine	30,49	5-HT1A	51,57	5-hydroxytryptamine	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	modulation|nmod|START_ENTITY modulation|appos|END_ENTITY	In-vivo modulation of central 5-hydroxytryptamine -LRB- 5-HT1A -RRB- receptor-mediated responses by the cholinergic system .
15574737	0	5-hydroxytryptamine	20,39	5-HT1A	188,194	5-hydroxytryptamine	5-HT1A	MESH:D012701	15550(Tax:10090)	Chemical	Gene	neuroendocrine|nsubj|START_ENTITY neuroendocrine|parataxis|containing containing|dobj|sequences sequences|nummod|END_ENTITY	Medial hypothalamic 5-hydroxytryptamine -LRB- 5-HT -RRB- 1A receptors regulate neuroendocrine responses to stress and exploratory locomotor activity : application of recombinant adenovirus containing 5-HT1A sequences .
1838408	0	5-hydroxytryptamine	11,30	5-HT1A	153,159	5-hydroxytryptamine	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	hippocampus|amod|START_ENTITY Release|nmod|hippocampus Release|dep|evidence evidence|nmod|regulation regulation|nmod|autoreceptors autoreceptors|nummod|END_ENTITY	Release of 5-hydroxytryptamine -LRB- 5-HT -RRB- from medullary and mesencephalic raph neurones after grafting to the rat hippocampus : evidence for regulation by 5-HT1A autoreceptors .
2832770	0	5-hydroxytryptamine	81,100	5-HT1A	129,135	5-hydroxytryptamine	5-HT1A	MESH:D012701	3350	Chemical	Gene	sites|amod|START_ENTITY sites|nmod|subtype subtype|nummod|END_ENTITY	Urapidil and some analogues with hypotensive properties show high affinities for 5-hydroxytryptamine -LRB- 5-HT -RRB- binding sites of the 5-HT1A subtype and for alpha 1-adrenoceptor binding sites .
7620698	0	5-hydroxytryptamine	14,33	5-HT1A	88,94	5-hydroxytryptamine	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY controlled|nsubjpass|release controlled|nmod|END_ENTITY	Evidence that 5-hydroxytryptamine release in rat dorsal raph nucleus is controlled by 5-HT1A , 5-HT1B and 5-HT1D autoreceptors .
8632181	0	5-hydroxytryptamine	50,69	5-HT1A	142,148	5-hydroxytryptamine	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	reduces|dobj|START_ENTITY reduces|nmod|activation activation|nmod|receptors receptors|nummod|END_ENTITY	Flesinoxan dose-dependently reduces extracellular 5-hydroxytryptamine -LRB- 5-HT -RRB- in rat median raphe and dorsal hippocampus through activation of 5-HT1A receptors .
8882615	0	5-hydroxytryptamine	75,94	5-HT1A	96,102	5-hydroxytryptamine	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Antagonistic actions of renal dopamine and 5-hydroxytryptamine : endogenous 5-hydroxytryptamine , 5-HT1A receptors and antinatriuresis during high_sodium intake .
8982649	0	5-hydroxytryptamine	147,166	5-HT1A	6,12	5-hydroxytryptamine	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	restrain|xcomp|START_ENTITY restrain|nsubj|autoreceptors autoreceptors|amod|Raphe Raphe|dep|END_ENTITY	Raphe 5-HT1A autoreceptors , but not postsynaptic 5-HT1A receptors or beta-adrenoceptors , restrain the citalopram-induced increase in extracellular 5-hydroxytryptamine in vivo .
9089665	0	5-hydroxytryptamine	63,82	5-HT1A	17,23	5-hydroxytryptamine	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY agonist|nmod|release agonist|amod|END_ENTITY	The effects of a 5-HT1A receptor agonist and antagonist on the 5-hydroxytryptamine release in the central nucleus of the amygdala : a microdialysis study with flesinoxan and WAY_100635 .
9375971	0	5-hydroxytryptamine	97,116	5-HT1A	28,34	5-hydroxytryptamine	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	effect|amod|START_ENTITY effect|nmod|alnespirone alnespirone|amod|selective selective|dep|agonists agonists|nummod|END_ENTITY	The effect of the selective 5-HT1A agonists alnespirone -LRB- S-20499 -RRB- and 8-OH-DPAT on extracellular 5-hydroxytryptamine in different regions of rat brain .
15496296	0	5-hydroxytryptamine	22,41	5-HT1D	87,93	5-hydroxytryptamine	5-HT1D	MESH:D012701	25323(Tax:10116)	Chemical	Gene	released|xcomp|START_ENTITY released|nsubj|reflex reflex|nmod|receptors receptors|nummod|END_ENTITY	Endogenously released 5-hydroxytryptamine depresses the spinal monosynaptic reflex via 5-HT1D receptors .
17584957	0	5-hydroxytryptamine	41,60	5-HT2B	146,152	5-hydroxytryptamine	5-HT2B	MESH:D012701	29581(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY release|nmod|END_ENTITY	Stimulation of growth hormone release by 5-hydroxytryptamine -LRB- 5-HT -RRB- in cultured rat anterior pituitary cell aggregates : evidence for mediation by 5-HT2B , 5-HT7 , 5-HT1B , and ketanserin-sensitive receptors .
15157181	0	5-hydroxytryptamine	4,23	5-HT3	32,37	5-hydroxytryptamine	5-HT3	MESH:D012701	3359	Chemical	Gene	type|amod|START_ENTITY type|appos|END_ENTITY	The 5-hydroxytryptamine type 3 -LRB- 5-HT3 -RRB- receptor reveals a novel determinant of single-channel conductance .
137809	0	5-hydroxytryptamine	58,77	ATPase	25,31	5-hydroxytryptamine	ATPase	MESH:D012701	1769	Chemical	Gene	concentrations|nmod|START_ENTITY END_ENTITY|nmod|concentrations	Inhibition of actomyosin ATPase by high concentrations of 5-hydroxytryptamine .
26677676	1	5-hydroxytryptamine	36,55	Brain_Derived_Neurotrophic_Factor	112,145	5-hydroxytryptamine	Brain Derived Neurotrophic Factor	MESH:D012701	24225(Tax:10116)	Chemical	Gene	System|amod|START_ENTITY System|nmod|END_ENTITY	I Recipe on 5-hydroxytryptamine Signal System and mRNA Expression Levels of Hippocampal Brain_Derived_Neurotrophic_Factor in Visceral Hypersensitivity Rats with Irritable Bowel Syndrome -RSB- .
2289525	0	5-hydroxytryptamine	47,66	Endothelin-1	0,12	5-hydroxytryptamine	Endothelin-1	MESH:D012701	100009270(Tax:9986)	Chemical	Gene	increases|nmod|START_ENTITY increases|nsubj|END_ENTITY	Endothelin-1 increases arterial sensitivity to 5-hydroxytryptamine .
15048642	0	5-hydroxytryptamine	18,37	HTR2A	51,56	5-hydroxytryptamine	HTR2A	MESH:D012701	3356	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	102T/C SNP in the 5-hydroxytryptamine receptor 2A -LRB- HTR2A -RRB- gene and schizophrenia in two southern Han Chinese populations : lack of association .
24477975	0	5-hydroxytryptamine	32,51	HTR3C	65,70	5-hydroxytryptamine	HTR3C	MESH:D012701	170572	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Association between variants of 5-hydroxytryptamine receptor 3C -LRB- HTR3C -RRB- and chemotherapy-induced symptoms in women receiving adjuvant treatment for breast_cancer .
20573591	0	5-hydroxytryptamine	29,48	ghrelin	73,80	5-hydroxytryptamine	ghrelin	MESH:D012701	59301(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|effects effects|nmod|END_ENTITY	Hypothalamic paraventricular 5-hydroxytryptamine inhibits the effects of ghrelin on eating and energy substrate utilization .
16332411	0	5-hydroxytryptamine	21,40	neuropeptide_Y	95,109	5-hydroxytryptamine	neuropeptide Y	MESH:D012701	109648(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Inhibitory effect of 5-hydroxytryptamine on hyperphagia in mice with genetic overexpression of neuropeptide_Y .
6422173	0	5-hydroxytryptamine	27,46	neurotensin	80,91	5-hydroxytryptamine	neurotensin	MESH:D012701	299757(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|effect effect|nmod|END_ENTITY	Participation of mast cell 5-hydroxytryptamine in the vasoconstrictor effect of neurotensin in the rat perfused hindquarter .
7957540	0	5-hydroxytryptamine	78,97	prolactin	24,33	5-hydroxytryptamine	prolactin	MESH:D012701	5617	Chemical	Gene	index|nmod|START_ENTITY release|nmod|index release|nsubj|END_ENTITY	Dexfenfluramine-induced prolactin release as an index of central synaptosomal 5-hydroxytryptamine during treatment with fluoxetine .
8738159	0	5-hydroxytryptamine	14,33	somatostatin	41,53	5-hydroxytryptamine	somatostatin	MESH:D012701	24797(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|system system|compound|END_ENTITY	Modulation by 5-hydroxytryptamine of the somatostatin receptor-effector system and somatostatin levels in rat brain .
3676757	0	5-hydroxytryptophan	86,105	Prolactin	0,9	5-hydroxytryptophan	Prolactin	CHEBI:28171	24683(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY secretion|dep|effects secretion|compound|END_ENTITY	Prolactin secretion in posterior pituitary lobectomized rats : differential effects of 5-hydroxytryptophan and ether .
11011048	0	5-hydroxytryptophan	83,102	leptin	6,12	5-hydroxytryptophan	leptin	CHEBI:28171	16846(Tax:10090)	Chemical	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	Serum leptin levels after central and systemic injection of a serotonin precursor , 5-hydroxytryptophan , in mice .
16508167	0	5-hydroxytryptophan	71,90	leptin	15,21	5-hydroxytryptophan	leptin	CHEBI:28171	16846(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of leptin in hypophagia induced by the serotonin precursor 5-hydroxytryptophan -LRB- 5-HTP -RRB- in mice .
1087036	0	5-hydroxytryptophan	27,46	prolactin	57,66	5-hydroxytryptophan	prolactin	CHEBI:28171	24683(Tax:10116)	Chemical	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	Effect of apomorphine plus 5-hydroxytryptophan on plasma prolactin levels in male rats .
6602260	0	5-hydroxytryptophan	80,99	prolactin	40,49	5-hydroxytryptophan	prolactin	CHEBI:28171	24683(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Effects Effects|nmod|naloxone naloxone|nmod|secretion secretion|nmod|END_ENTITY	Effects of naloxone on the secretion of prolactin and corticosterone induced by 5-hydroxytryptophan and a serotonergic agonist , mCPP .
9612848	0	5-hydroxytryptophan	49,68	prolactin	27,36	5-hydroxytryptophan	prolactin	CHEBI:28171	24683(Tax:10116)	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Lithium enhancement of the prolactin response to 5-hydroxytryptophan is not reversible by inositol .
14718513	0	5-inositol	26,36	SHIP	50,54	5-inositol	SHIP	null	16331(Tax:10090)	Chemical	Gene	phosphatase|amod|START_ENTITY phosphatase|appos|END_ENTITY	Src homology 2-containing 5-inositol phosphatase -LRB- SHIP -RRB- suppresses an early stage of lymphoid cell development through elevated interleukin-6 production by myeloid cells in bone marrow .
1939061	0	5-iodouracil	51,63	dihydropyrimidine_dehydrogenase	16,47	5-iodouracil	dihydropyrimidine dehydrogenase	MESH:C048747	281124(Tax:9913)	Chemical	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of dihydropyrimidine_dehydrogenase by 5-iodouracil .
272480	0	5-methoxytryptamine	15,34	MAO	74,77	5-methoxytryptamine	MAO	MESH:D008735	29253(Tax:10116)	Chemical	Gene	Deamination|nmod|START_ENTITY Deamination|nmod|END_ENTITY	Deamination of 5-methoxytryptamine , serotonin and phenylethylamine by rat MAO in vitro and in vivo .
12925791	0	5-methyl-6-N-methylanilino_pyridopyrimidine_antifolate	56,110	dihydrofolate_reductase	130,153	5-methyl-6-N-methylanilino pyridopyrimidine antifolate	dihydrofolate reductase	null	1719	Chemical	Gene	complex|amod|START_ENTITY complex|nmod|END_ENTITY	Analysis of three crystal structure determinations of a 5-methyl-6-N-methylanilino_pyridopyrimidine_antifolate complex with human dihydrofolate_reductase .
8275462	0	5-methylcytosine	62,78	O6-methylguanine-DNA_methyltransferase	20,58	5-methylcytosine	O6-methylguanine-DNA methyltransferase	MESH:D044503	4255	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of human O6-methylguanine-DNA_methyltransferase by 5-methylcytosine .
10656489	0	5-methylcytosine	0,16	p53	35,38	5-methylcytosine	p53	MESH:D044503	7157	Chemical	Gene	sites|amod|START_ENTITY sites|nmod|END_ENTITY	5-methylcytosine at HpaII sites in p53 is not hypermutable after UVC irradiation .
22798497	0	5-methylcytosines	25,42	APOBEC3A	59,67	5-methylcytosines	APOBEC3A	null	200315	Chemical	Gene	deamination|nmod|START_ENTITY deamination|nmod|END_ENTITY	Efficient deamination of 5-methylcytosines in DNA by human APOBEC3A , but not by AID or APOBEC3G .
3000448	0	5-methylcytosines	35,52	vitellogenin	68,80	5-methylcytosines	vitellogenin	null	424533(Tax:9031)	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Expression-linked demethylation of 5-methylcytosines in the chicken vitellogenin gene region .
10608809	0	5-methyltetrahydrofolate_pentaglutamate	45,84	glycine_N-methyltransferase	14,41	5-methyltetrahydrofolate pentaglutamate	glycine N-methyltransferase	MESH:C403520	25134(Tax:10116)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of glycine_N-methyltransferase by 5-methyltetrahydrofolate_pentaglutamate .
17367704	0	5-methyltetrahydrofolic_acid	0,28	endothelin-1	40,52	5-methyltetrahydrofolic acid	endothelin-1	CHEBI:15641	1906	Chemical	Gene	production|amod|START_ENTITY production|amod|END_ENTITY	5-methyltetrahydrofolic_acid stimulates endothelin-1 production in low density lipoprotein-treated human endothelial cells .
23964740	0	5-oxopyrrolopyridine	65,85	DPP4	86,90	5-oxopyrrolopyridine	DPP4	null	1803	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Optimization of activity , selectivity , and liability profiles in 5-oxopyrrolopyridine DPP4 inhibitors leading to clinical candidate -LRB- Sa -RRB- -2 - -LRB- 3 - -LRB- aminomethyl -RRB- -4 - -LRB- 2,4-dichlorophenyl -RRB- -2 - methyl-5-oxo-5H-pyrrolo -LSB- 3,4-b -RSB- pyridin-6 -LRB- 7H -RRB- - yl -RRB- - N,N-dimethylacetamide -LRB- BMS-767778 -RRB- .
23942809	0	5-phenyl-1H-pyrazol	64,83	BRAF	109,113	5-phenyl-1H-pyrazol	BRAF	null	673	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Synthesis , biological evaluation and molecular docking of novel 5-phenyl-1H-pyrazol derivatives as potential BRAF -LRB- V600E -RRB- inhibitors .
25267006	0	5-phenyl-1H-pyrazole	53,73	BRAF	99,103	5-phenyl-1H-pyrazole	BRAF	null	673	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Design , synthesis and biological evaluation of novel 5-phenyl-1H-pyrazole derivatives as potential BRAF -LRB- V600E -RRB- inhibitors .
7396409	0	5-phosphate	66,77	RPI	89,92	5-phosphate	RPI	null	22934	Chemical	Gene	isomerase|amod|START_ENTITY isomerase|appos|END_ENTITY	Biochemical genetics of the pentose_phosphate cycle : human ribose 5-phosphate isomerase -LRB- RPI -RRB- and ribulose_5-phosphate_3-epimerase -LRB- RPE -RRB- .
1705826	0	5-phospho-alpha-D-ribosyl-1-pyrophosphate	20,61	hypoxanthine-guanine_phosphoribosyltransferase	84,130	5-phospho-alpha-D-ribosyl-1-pyrophosphate	hypoxanthine-guanine phosphoribosyltransferase	null	3251	Chemical	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Localization of the 5-phospho-alpha-D-ribosyl-1-pyrophosphate binding site of human hypoxanthine-guanine_phosphoribosyltransferase .
240821	0	5-phosphoarabinonate	24,44	phosphoglucose_isomerase	72,96	5-phosphoarabinonate	phosphoglucose isomerase	MESH:C012188	2821	Chemical	Gene	START_ENTITY|nmod|probe probe|nmod|END_ENTITY	The enediolate analogue 5-phosphoarabinonate as a mechanistic probe for phosphoglucose_isomerase .
15993078	0	5-substituted-4-hydroxy-8-nitroquinazolines	44,87	EGFR	91,95	5-substituted-4-hydroxy-8-nitroquinazolines	EGFR	null	1956	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Synthesis and antitumor evaluation of novel 5-substituted-4-hydroxy-8-nitroquinazolines as EGFR signaling-targeted inhibitors .
22341941	0	5-substituted_1H-tetrazoles	6,33	cyclooxygenase-2	37,53	5-substituted 1H-tetrazoles	cyclooxygenase-2	null	5743	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Novel 5-substituted_1H-tetrazoles as cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors .
8670124	1	52-amino-acid	147,160	CEP52	180,185	52-amino-acid	CEP52	null	7311	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Rat cDNAs for a 52-amino-acid ribosomal protein -LRB- CEP52 -RRB- that is typically formed as a ubiquitin fusion protein , were cloned following reverse transcription and PCR amplification .
18634756	0	5Alpha-dihydrotestosterone	0,26	transthyretin	40,53	5Alpha-dihydrotestosterone	transthyretin	MESH:D013196	22139(Tax:10090)	Chemical	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	5Alpha-dihydrotestosterone up-regulates transthyretin levels in mice and rat choroid plexus via an androgen receptor independent pathway .
12168112	0	5FU	37,40	tumor_necrosis_factor-related_apoptosis-inducing_ligand	46,101	5FU	tumor necrosis factor-related apoptosis-inducing ligand	MESH:D005472	8743	Chemical	Gene	activity|nmod|START_ENTITY activity|nmod|END_ENTITY	Supra-additive antitumor activity of 5FU with tumor_necrosis_factor-related_apoptosis-inducing_ligand on gastric and colon_cancers in vitro .
16601286	0	5_17beta-hydroxysteroid	72,95	AKR1C3	111,117	5 17beta-hydroxysteroid	AKR1C3	null	8644	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	Increased expression of type 2 3alpha-hydroxysteroid dehydrogenase/type 5_17beta-hydroxysteroid dehydrogenase -LRB- AKR1C3 -RRB- and its relationship with androgen_receptor in prostate_carcinoma .
24550466	0	5a-dihydroprogesterone	110,132	progesterone_receptor	79,100	5a-dihydroprogesterone	progesterone receptor	null	100033883(Tax:9796)	Chemical	Gene	agonist|amod|START_ENTITY agonist|compound|END_ENTITY	Pregnancy without progesterone in horses defines a second endogenous biopotent progesterone_receptor agonist , 5a-dihydroprogesterone .
4294	0	5alpha-dihydrotestosterone	69,95	3alpha-hydroxysteroid_dehydrogenase	8,43	5alpha-dihydrotestosterone	3alpha-hydroxysteroid dehydrogenase	MESH:D013196	291283(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Nuclear 3alpha-hydroxysteroid_dehydrogenase -LRB- 3alphaOHD -RRB- activity for 5alpha-dihydrotestosterone in the rat prostate .
15538745	0	5alpha-dihydrotestosterone	0,26	CYP24	88,93	5alpha-dihydrotestosterone	CYP24	MESH:D013196	1591	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	5alpha-dihydrotestosterone inhibits 1alpha,25-dihydroxyvitamin _ D3-induced expression of CYP24 in human prostate_cancer cells .
20560974	0	5alphaDH-DOC	0,12	androgen_receptor	60,77	5alphaDH-DOC	androgen receptor	null	367	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	5alphaDH-DOC -LRB- 5alpha-dihydro-deoxycorticosterone -RRB- activates androgen_receptor in castration-resistant prostate_cancer .
19917278	0	6,7-dichloro-2-methylsulfonyl-3-N-tert-butylaminoquinoxaline	81,141	GLP-1_receptor	58,72	6,7-dichloro-2-methylsulfonyl-3-N-tert-butylaminoquinoxaline	GLP-1 receptor	MESH:C517397	14652(Tax:10090)	Chemical	Gene	agonist|xcomp|START_ENTITY agonist|nsubj|effects effects|nmod|END_ENTITY	Insulin-releasing and metabolic effects of small molecule GLP-1_receptor agonist 6,7-dichloro-2-methylsulfonyl-3-N-tert-butylaminoquinoxaline .
6746641	0	6-A	4,7	delta_5-3-ketosteroid_isomerase	29,60	6-A	delta 5-3-ketosteroid isomerase	null	3283	Chemical	Gene	structure|amod|START_ENTITY structure|nmod|END_ENTITY	The 6-A crystal structure of delta_5-3-ketosteroid_isomerase .
16134937	0	6-Acylamino-2-aminoquinolines	0,29	melanin-concentrating_hormone_1_receptor	40,80	6-Acylamino-2-aminoquinolines	melanin-concentrating hormone 1 receptor	null	2847	Chemical	Gene	START_ENTITY|nmod|antagonists antagonists|amod|END_ENTITY	6-Acylamino-2-aminoquinolines as potent melanin-concentrating_hormone_1_receptor antagonists .
23847159	0	6-Aryl_and_heterocycle_quinazoline	0,34	EGFR	57,61	6-Aryl and heterocycle quinazoline	EGFR	null	1956	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	6-Aryl_and_heterocycle_quinazoline derivatives as potent EGFR inhibitors with improved activity toward gefitinib-sensitive and - resistant tumor cell lines .
15643080	0	6-BA	12,16	lupin	79,84	6-BA	lupin	null	51251	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of 6-BA on cluster root formation and organic_acid exudation in white lupin grown under phosphorus_deficiency -RSB- .
24373993	0	6-Hydroxydopamine	0,17	GDF5	50,54	6-Hydroxydopamine	GDF5	MESH:D016627	252835(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|expression expression|compound|END_ENTITY	6-Hydroxydopamine induces distinct alterations in GDF5 and GDNF mRNA expression in the rat nigrostriatal system in vivo .
22846799	0	6-Hydroxydopamine	0,17	iron_regulatory_protein_1	30,55	6-Hydroxydopamine	iron regulatory protein 1	MESH:D016627	48	Chemical	Gene	upregulates|amod|START_ENTITY upregulates|amod|END_ENTITY	6-Hydroxydopamine upregulates iron_regulatory_protein_1 by activating certain protein kinase C isoforms in the dopaminergic MES23 .5 cell line .
17146432	0	6-Mercaptopurine	0,16	Nur77	34,39	6-Mercaptopurine	Nur77	MESH:D015122	3164	Chemical	Gene	START_ENTITY|appos|activator activator|nmod|END_ENTITY	6-Mercaptopurine , an activator of Nur77 , enhances transcriptional activity of HIF-1alpha resulting in new vessel formation .
15956351	0	6-Mercaptopurine	49,65	TRAP220	0,7	6-Mercaptopurine	TRAP220	MESH:D015122	5469	Chemical	Gene	modulated|nmod|START_ENTITY modulated|nsubjpass|END_ENTITY	TRAP220 is modulated by the antineoplastic agent 6-Mercaptopurine , and mediates the activation of the NR4A subgroup of nuclear receptors .
27075886	0	6-Mercaptopurine	0,16	tumor_necrosis_factor-a	28,51	6-Mercaptopurine	tumor necrosis factor-a	MESH:D015122	21926(Tax:10090)	Chemical	Gene	attenuates|amod|START_ENTITY END_ENTITY|nsubj|attenuates	6-Mercaptopurine attenuates tumor_necrosis_factor-a production in microglia through Nur77-mediated transrepression and PI3K/Akt/mTOR signaling-mediated translational regulation .
1309569	0	6-Methylmercaptopurine_riboside	0,31	protein_kinase_N	101,117	6-Methylmercaptopurine riboside	protein kinase N	MESH:D008778	29355(Tax:10116)	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	6-Methylmercaptopurine_riboside is a potent and selective inhibitor of nerve growth factor-activated protein_kinase_N .
17576820	0	6-Methylprednisolone	0,20	IRAK-M	36,42	6-Methylprednisolone	IRAK-M	MESH:D008775	11213	Chemical	Gene	down-regulates|amod|START_ENTITY END_ENTITY|nsubj|down-regulates	6-Methylprednisolone down-regulates IRAK-M in human and murine osteoclasts and boosts bone-resorbing activity : a putative mechanism for corticoid-induced osteoporosis .
11166033	0	6-N-hydroxylaminopurine	41,64	LYS2	72,76	6-N-hydroxylaminopurine	LYS2	MESH:C032610	852412(Tax:4932)	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Mutagenic specificity of the base analog 6-N-hydroxylaminopurine in the LYS2 gene of yeast Saccharomyces_cerevisiae .
8231822	0	6-N-hydroxylaminopurine	41,64	URA3	72,76	6-N-hydroxylaminopurine	URA3	MESH:C032610	856692(Tax:4932)	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Mutagenic specificity of the base analog 6-N-hydroxylaminopurine in the URA3 gene of the yeast Saccharomyces_cerevisiae .
11308021	0	6-O-sulfo_de-N-acetylsialyl_Lewis_X	0,35	L-selectin	78,88	6-O-sulfo de-N-acetylsialyl Lewis X	L-selectin	MESH:C433828	6402	Chemical	Gene	ligand|amod|START_ENTITY ligand|nmod|END_ENTITY	6-O-sulfo_de-N-acetylsialyl_Lewis_X as a novel high-affinity ligand for human L-selectin : total synthesis and structural characterization .
16126007	0	6-OHDA	82,88	AADC	24,28	6-OHDA	AADC	MESH:D016627	24311(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Dimerizer regulation of AADC expression and behavioral response in AAV-transduced 6-OHDA lesioned rats .
18462913	0	6-OHDA	44,50	Akt	73,76	6-OHDA	Akt	MESH:D016627	24185(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nmod|END_ENTITY	Neurotrophin-3 reduces apoptosis induced by 6-OHDA in PC12 cells through Akt signaling pathway .
19224173	0	6-OHDA	0,6	ERK1/2	79,85	6-OHDA	ERK1/2	MESH:D016627	50689;116590	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	6-OHDA induces cycle reentry and apoptosis of PC12 cells through activation of ERK1/2 signaling pathway .
10877911	0	6-OHDA	110,116	GDNF	152,156	6-OHDA	GDNF	MESH:D016627	14573(Tax:10090)	Chemical	Gene	model|amod|START_ENTITY model|nmod|disease disease|acl|using using|dobj|END_ENTITY	Lentiviral vectors as a gene delivery system in the mouse midbrain : cellular and behavioral improvements in a 6-OHDA model of Parkinson 's _ disease using GDNF .
11031079	0	6-OHDA	70,76	GDNF	14,18	6-OHDA	GDNF	MESH:D016627	25453(Tax:10116)	Chemical	Gene	lesion|nummod|START_ENTITY nigra|nmod|lesion gene|nmod|nigra gene|amod|END_ENTITY	Delivery of a GDNF gene into the substantia nigra after a progressive 6-OHDA lesion maintains functional nigrostriatal connections .
11069582	0	6-OHDA	89,95	GDNF	63,67	6-OHDA	GDNF	MESH:D016627	2668	Chemical	Gene	model|nummod|START_ENTITY END_ENTITY|nmod|model	Preservation of a functional nigrostriatal dopamine pathway by GDNF in the intrastriatal 6-OHDA lesion model depends on the site of administration of the trophic factor .
11277973	0	6-OHDA	40,46	GDNF	27,31	6-OHDA	GDNF	MESH:D016627	25453(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Neuroprotective effects of GDNF against 6-OHDA in young and aged rats .
14599485	0	6-OHDA	173,179	GDNF	55,59	6-OHDA	GDNF	MESH:D016627	25453(Tax:10116)	Chemical	Gene	model|appos|START_ENTITY restoration|nmod|model Effect|nmod|restoration Effect|nmod|co-transplantation co-transplantation|appos|END_ENTITY	Effect of glial_cell_line-derived_neurotrophic_factor -LRB- GDNF -RRB- co-transplantation with fetal ventral mesencephalic cells -LRB- VMC -RRB- on functional restoration in 6-hydroxydopamine -LRB- 6-OHDA -RRB- lesioned rat model of Parkinson 's _ disease : neurobehavioral , neurochemical and immunohistochemical studies .
14637123	0	6-OHDA	94,100	GDNF	61,65	6-OHDA	GDNF	MESH:D016627	100413758	Chemical	Gene	lesion|nummod|START_ENTITY protection|nmod|lesion provides|dobj|protection provides|nsubj|delivery delivery|nmod|END_ENTITY	Recombinant adeno-associated viral vector -LRB- rAAV -RRB- delivery of GDNF provides protection against 6-OHDA lesion in the common_marmoset monkey -LRB- Callithrix_jacchus -RRB- .
19389387	0	6-OHDA	111,117	GDNF	11,15	6-OHDA	GDNF	MESH:D016627	25453(Tax:10116)	Chemical	Gene	model|amod|START_ENTITY cells|nmod|model function|nmod|cells pretreatment|nmod|function pretreatment|nsubj|Effects Effects|nmod|END_ENTITY	Effects of GDNF pretreatment on function and survival of transplanted fetal ventral mesencephalic cells in the 6-OHDA rat model of Parkinson 's _ disease .
21969113	0	6-OHDA	127,133	GDNF	24,28	6-OHDA	GDNF	MESH:D016627	2668	Chemical	Gene	toxicity|nummod|START_ENTITY cells|nmod|toxicity protection|nmod|cells critical|nmod|protection critical|nsubj|quantities quantities|nmod|END_ENTITY	Optimized quantities of GDNF overexpressed by engineered astrocytes are critical for protection of neuroblastoma cells against 6-OHDA toxicity .
24583079	5	6-OHDA	847,853	GDNF	880,884	6-OHDA	GDNF	MESH:D016627	25453(Tax:10116)	Chemical	Gene	injections|appos|START_ENTITY produced|nmod|injections injected|advcl|produced injected|nsubjpass|microspheres microspheres|compound|END_ENTITY	After a rat model of PD was produced by 6-hydroxydompamine -LRB- 6-OHDA -RRB- injections , lipid-coated GDNF microspheres -LRB- 1.5 mg/kg -RRB- were injected into the striatum of PD rats .
8742486	0	6-OHDA	22,28	GDNF	0,4	6-OHDA	GDNF	MESH:D016627	25453(Tax:10116)	Chemical	Gene	lesion|nummod|START_ENTITY protects|nmod|lesion protects|nsubj|END_ENTITY	GDNF protects against 6-OHDA nigrostriatal lesion : in vivo study with microdialysis and PET .
9278545	0	6-OHDA	24,30	GDNF	0,4	6-OHDA	GDNF	MESH:D016627	25453(Tax:10116)	Chemical	Gene	protection|nmod|START_ENTITY protection|amod|END_ENTITY	GDNF protection against 6-OHDA : time dependence and requirement for protein synthesis .
25195972	0	6-OHDA	74,80	NF-kB	46,51	6-OHDA	NF-kB	MESH:D016627	81736(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY activation|acl|induced activation|amod|END_ENTITY	Minocycline inhibits ICAD degradation and the NF-kB activation induced by 6-OHDA in PC12 cells .
1200981	0	6-Phosphogluconate	0,18	PGD	34,37	6-Phosphogluconate	PGD	MESH:C008884	236539(Tax:10090)	Chemical	Gene	genetics|amod|START_ENTITY genetics|appos|END_ENTITY	6-Phosphogluconate dehydrogenase -LRB- PGD -RRB- genetics in the mouse : linkage with metabolically related enzyme loci .
12383755	0	6-Phosphogluconate	0,18	PGD	34,37	6-Phosphogluconate	PGD	MESH:C008884	26227	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	6-Phosphogluconate dehydrogenase -LRB- PGD -RRB- allele phylogeny is incongruent with a recent origin of polyploidization in some North American Sphaeriidae -LRB- Mollusca , Bivalvia -RRB- .
21868511	0	6-Thioguanine	0,13	parathyroid_hormone-related_protein	28,63	6-Thioguanine	parathyroid hormone-related protein	MESH:D013866	5744	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|expression expression|amod|END_ENTITY	6-Thioguanine inhibition of parathyroid_hormone-related_protein expression is mediated by GLI2 .
27020304	0	6-alkyl-substituted_3-methyl-pyridine-2-carbonyl_amino_dimethyl-benzoic_acid	42,118	EP4	119,122	6-alkyl-substituted 3-methyl-pyridine-2-carbonyl amino dimethyl-benzoic acid	EP4	null	5734	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|compound|END_ENTITY	Identification and biological activity of 6-alkyl-substituted_3-methyl-pyridine-2-carbonyl_amino_dimethyl-benzoic_acid EP4 antagonists .
17889528	0	6-alkynyl-4-anilinoquinazoline	51,81	EGFR	104,108	6-alkynyl-4-anilinoquinazoline	EGFR	null	1956	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Synthesis and biological evaluation of substituted 6-alkynyl-4-anilinoquinazoline derivatives as potent EGFR inhibitors .
8626749	0	6-aminonicotinamide	43,62	RIF-1	80,85	6-aminonicotinamide	RIF-1	MESH:D015120	55183	Chemical	Gene	START_ENTITY|nmod|metabolism metabolism|nmod|END_ENTITY	13C and 31P NMR investigation of effect of 6-aminonicotinamide on metabolism of RIF-1 tumor cells in vitro .
3161339	0	6-aminonicotinamide	10,29	renin	33,38	6-aminonicotinamide	renin	MESH:D015120	24715(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	Effect of 6-aminonicotinamide on renin release in isolated rat kidney : possible role for the pentose pathway .
16420034	0	6-aryl-7-isopropylquinazolinones	50,82	TRPV1	92,97	6-aryl-7-isopropylquinazolinones	TRPV1	null	83810(Tax:10116)	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|compound|END_ENTITY	Identification and biological characterization of 6-aryl-7-isopropylquinazolinones as novel TRPV1 antagonists that are effective in models of chronic_pain .
22004567	0	6-aryl_benzimidazol-2-ones	81,107	progesterone_receptor	123,144	6-aryl benzimidazol-2-ones	progesterone receptor	null	5241	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Receptor-based QSAR study for a series of 3,3-disubstituted-5-aryl _ oxindoles and 6-aryl_benzimidazol-2-ones derivatives as progesterone_receptor inhibitors .
23496085	0	6-arylquinazolin-4-amines	46,71	Dyrk1A	168,174	6-arylquinazolin-4-amines	Dyrk1A	null	1859	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Pharmacophore and 3D-QSAR characterization of 6-arylquinazolin-4-amines as Cdc2-like_kinase_4 -LRB- Clk4 -RRB- and dual_specificity_tyrosine-phosphorylation-regulated_kinase_1A -LRB- Dyrk1A -RRB- inhibitors .
3382675	0	6-azacholest-4-en-3_beta-ol-7-one	15,48	cholesterol_7_alpha-hydroxylase	66,97	6-azacholest-4-en-3 beta-ol-7-one	cholesterol 7 alpha-hydroxylase	null	25428(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|inhibitor inhibitor|nmod|END_ENTITY	The effects of 6-azacholest-4-en-3_beta-ol-7-one , an inhibitor of cholesterol_7_alpha-hydroxylase , on cholesterol metabolism and bile_acid synthesis in primary cultures of rat hepatocytes .
12470677	0	6-chloroacetyl-2-dimethylaminonaphthalene	34,75	glutathione_transferases	131,155	6-chloroacetyl-2-dimethylaminonaphthalene	glutathione transferases	MESH:C478192	373156	Chemical	Gene	Synthesis|nmod|START_ENTITY Synthesis|nmod|END_ENTITY	Synthesis and characterization of 6-chloroacetyl-2-dimethylaminonaphthalene as a fluorogenic substrate and a mechanistic probe for glutathione_transferases .
2265452	0	6-ethylmercaptopurine	23,44	c-myc	48,53	6-ethylmercaptopurine	c-myc	MESH:C010149	4609	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Differential effect of 6-ethylmercaptopurine on c-myc expression in wild-type and HGPRT-deficient HL-60 cells .
24378641	0	6-fatty_acid	56,68	FADS2	81,86	6-fatty acid	FADS2	null	56473(Tax:10090)	Chemical	Gene	deficiency|amod|START_ENTITY deficiency|appos|END_ENTITY	Obesity resistance and deregulation of lipogenesis in / \ 6-fatty_acid desaturase -LRB- FADS2 -RRB- deficiency .
17043111	0	6-fluoro-8-methoxy_quinolone_gatifloxacin	4,45	interleukin-8	61,74	6-fluoro-8-methoxy quinolone gatifloxacin	interleukin-8	null	3576	Chemical	Gene	production|amod|START_ENTITY production|amod|END_ENTITY	The 6-fluoro-8-methoxy_quinolone_gatifloxacin down-regulates interleukin-8 production in prostate cell line PC-3 .
17978497	0	6-formylpterin	21,35	HIF-1alpha	39,49	6-formylpterin	HIF-1alpha	MESH:C005926	3091	Chemical	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	Inhibitory effect of 6-formylpterin on HIF-1alpha protein accumulation .
10699495	0	6-formylpterin	11,25	xanthine_oxidase	29,45	6-formylpterin	xanthine oxidase	MESH:C005926	22436(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effects of 6-formylpterin , a xanthine_oxidase inhibitor and a superoxide scavenger , on production of nitric_oxide in RAW 264.7 macrophages .
14534317	0	6-hydroxy-D-nicotine	64,84	pAO1	129,133	6-hydroxy-D-nicotine	pAO1	null	54498	Chemical	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Characterization of HdnoR , the transcriptional repressor of the 6-hydroxy-D-nicotine oxidase gene of Arthrobacter nicotinovorans pAO1 , and its DNA-binding activity in response to L - _ and_D-nicotine Derivatives .
7749731	0	6-hydroxydopamine	46,63	GDNF	0,4	6-hydroxydopamine	GDNF	MESH:D016627	25453(Tax:10116)	Chemical	Gene	protects|nmod|START_ENTITY protects|nsubj|END_ENTITY	GDNF protects nigral dopamine neurons against 6-hydroxydopamine in vivo .
15755737	0	6-hydroxydopamine	48,65	Manganese_superoxide_dismutase	0,30	6-hydroxydopamine	Manganese superoxide dismutase	MESH:D016627	20656(Tax:10090)	Chemical	Gene	injury|amod|START_ENTITY protects|nmod|injury protects|nsubj|END_ENTITY	Manganese_superoxide_dismutase protects against 6-hydroxydopamine injury in mouse brains .
28554	0	6-hydroxydopamine	70,87	Tyrosine_hydroxylase	0,20	6-hydroxydopamine	Tyrosine hydroxylase	MESH:D016627	25085(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Tyrosine_hydroxylase activity in brain regions after intraventricular 6-hydroxydopamine in the neonatal rat .
2865349	0	6-hydroxydopamine	108,125	Tyrosine_hydroxylase	0,20	6-hydroxydopamine	Tyrosine hydroxylase	MESH:D016627	7054	Chemical	Gene	effect|nmod|START_ENTITY activity|dep|effect activity|amod|END_ENTITY	Tyrosine_hydroxylase activity in the sympathoadrenal system under basal and stressful conditions : effect of 6-hydroxydopamine .
20125122	0	6-hydroxydopamine	49,66	divalent_metal_transporter_1	17,45	6-hydroxydopamine	divalent metal transporter 1	MESH:D016627	4891	Chemical	Gene	intoxication|amod|START_ENTITY END_ENTITY|nmod|intoxication	Up-regulation of divalent_metal_transporter_1 in 6-hydroxydopamine intoxication is IRE/IRP dependent .
3084169	0	6-hydroxydopamine	10,27	lipoprotein_lipase	37,55	6-hydroxydopamine	lipoprotein lipase	MESH:D016627	16956(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of 6-hydroxydopamine on heart lipoprotein_lipase activity in mice .
1970504	1	6-hydroxydopamine	128,145	neurotensin	149,160	6-hydroxydopamine	neurotensin	MESH:D016627	299757(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|content content|compound|END_ENTITY	Effects of unilateral nigral lesion with 6-hydroxydopamine on neurotensin content and its binding site density .
3102265	0	6-hydroxydopamine	14,31	prolactin	89,98	6-hydroxydopamine	prolactin	MESH:D016627	443317(Tax:9940)	Chemical	Gene	infusion|amod|START_ENTITY effect|nmod|infusion effect|nmod|levels levels|compound|END_ENTITY	The effect of 6-hydroxydopamine infusion into the third cerebral ventricle on the plasma prolactin levels in anoestrous ewes subjected to prolonged and repeated stress .
10865059	0	6-hydroxydopamine	177,194	tyrosine_hydroxylase	29,49	6-hydroxydopamine	tyrosine hydroxylase	MESH:D016627	25085(Tax:10116)	Chemical	Gene	injections|nmod|START_ENTITY bundle|nsubj|injections bundle|nmod|expression expression|nmod|immunoreactivities immunoreactivities|amod|END_ENTITY	On the altered expression of tyrosine_hydroxylase and calbindin-D_28kD immunoreactivities and viability of neurons in the ventral tegmental area of Tsai following injections of 6-hydroxydopamine in the medial forebrain bundle in the rat .
24604006	0	6-hydroxydopamine	113,130	tyrosine_hydroxylase	10,30	6-hydroxydopamine	tyrosine hydroxylase	MESH:D016627	7054	Chemical	Gene	model|amod|START_ENTITY hemisphere|nmod|model accompanied|nmod|hemisphere accompanied|nsubj|expression expression|compound|END_ENTITY	Increased tyrosine_hydroxylase expression accompanied by glial changes within the non-lesioned hemisphere in the 6-hydroxydopamine model of Parkinson 's _ disease .
25230286	0	6-hydroxydopamine	30,47	tyrosine_hydroxylase	82,102	6-hydroxydopamine	tyrosine hydroxylase	MESH:D016627	25085(Tax:10116)	Chemical	Gene	results|amod|START_ENTITY results|nmod|number number|nmod|cells cells|amod|END_ENTITY	Intraventricular injection of 6-hydroxydopamine results in an increased number of tyrosine_hydroxylase immune-positive cells in the rat cortex .
6101509	0	6-hydroxydopamine	105,122	tyrosine_hydroxylase	25,45	6-hydroxydopamine	tyrosine hydroxylase	MESH:D016627	25085(Tax:10116)	Chemical	Gene	injections|nmod|START_ENTITY increase|nmod|injections increase|nmod|activity activity|amod|END_ENTITY	Compensatory increase in tyrosine_hydroxylase activity in rat brain after intraventricular injections of 6-hydroxydopamine .
8097862	0	6-hydroxydopamine	107,124	tyrosine_hydroxylase	30,50	6-hydroxydopamine	tyrosine hydroxylase	MESH:D016627	25085(Tax:10116)	Chemical	Gene	lesions|amod|START_ENTITY mRNAs|nmod|lesions mRNAs|nsubj|Quantitation Quantitation|nmod|levels levels|nmod|END_ENTITY	Quantitation of the levels of tyrosine_hydroxylase and preproenkephalin mRNAs in nigrostriatal sites after 6-hydroxydopamine lesions .
8930333	0	6-hydroxydopamine	190,207	tyrosine_hydroxylase	130,150	6-hydroxydopamine	tyrosine hydroxylase	MESH:D016627	7054	Chemical	Gene	lesions|amod|START_ENTITY sites|nmod|lesions associated|nmod|sites associated|nmod|reappearance reappearance|nmod|immunoreactivity immunoreactivity|amod|END_ENTITY	Altered Fos-like immunoreactivity in terminal regions of the mesotelencephalic dopamine system is associated with reappearance of tyrosine_hydroxylase immunoreactivity at the sites of focal 6-hydroxydopamine lesions in the nucleus accumbens .
21561780	0	6-isoprenoid-substituted_flavanone	36,70	Tyrosinase	0,10	6-isoprenoid-substituted flavanone	Tyrosinase	null	7299	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Tyrosinase inhibitory activity of a 6-isoprenoid-substituted_flavanone isolated from Dalea elegans .
7756431	0	6-keto-PGF1_alpha_and_thromboxane_B2	61,97	CV-3988	49,56	6-keto-PGF1 alpha and thromboxane B2	CV-3988	null	2549994(Tax:243365)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of platelet activating factor antagonist -LRB- CV-3988 -RRB- on 6-keto-PGF1_alpha_and_thromboxane_B2 in dogs with experimental endotoxin-induced shock .
24211998	0	6-mercaptopurine	95,111	GCE	32,35	6-mercaptopurine	GCE	MESH:D015122	275	Chemical	Gene	biosensor|nmod|START_ENTITY biosensor|compound|END_ENTITY	Establishment of dsDNA/GNs/chit / GCE biosensor and electrochemical study on interaction between 6-mercaptopurine and DNA .
26068522	0	6-methylcoumarin	36,52	CYP2A6	102,108	6-methylcoumarin	CYP2A6	MESH:C018096	1548	Chemical	Gene	oxidation|acl|START_ENTITY oxidation|nmod|END_ENTITY	Inhibitory effects and oxidation of 6-methylcoumarin , 7-methylcoumarin and 7-formylcoumarin via human CYP2A6 and its mouse and pig orthologous enzymes .
7042021	0	6-oxo-prostaglandin_E1	32,54	renin	15,20	6-oxo-prostaglandin E1	renin	MESH:C022950	100358545(Tax:9986)	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|Stimulation Stimulation|nmod|END_ENTITY	Stimulation of renin release by 6-oxo-prostaglandin_E1 and prostacyclin .
3178763	0	6-spermyne	93,103	S-adenosylmethionine_decarboxylase	24,58	6-spermyne	S-adenosylmethionine decarboxylase	MESH:C057395	11702(Tax:10090)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|activity activity|amod|END_ENTITY	Selective regulation of S-adenosylmethionine_decarboxylase activity by the spermine analogue 6-spermyne .
14751222	0	6-tetrahydrobiopterin	22,43	tyrosinase	47,57	6-tetrahydrobiopterin	tyrosinase	null	7299	Chemical	Gene	oxidation|nmod|START_ENTITY oxidation|nmod|END_ENTITY	Indirect oxidation of 6-tetrahydrobiopterin by tyrosinase .
12639547	0	6-thiazolylquinazolines	91,114	EGFR	58,62	6-thiazolylquinazolines	EGFR	null	1956	Chemical	Gene	inhibitors|dep|START_ENTITY inhibitors|amod|END_ENTITY	Discovery and biological evaluation of potent dual ErbB-2 / EGFR tyrosine kinase inhibitors : 6-thiazolylquinazolines .
21172256	0	6-thioguanine	5,18	TPMT	32,36	6-thioguanine	TPMT	MESH:D013866	7172	Chemical	Gene	therapy|amod|START_ENTITY therapy|nmod|END_ENTITY	Safe 6-thioguanine therapy of a TPMT deficient Crohn 's _ disease patient by using therapeutic drug monitoring .
8844990	0	6-thioguanine	22,35	gpt	54,57	6-thioguanine	gpt	MESH:D013866	2875	Chemical	Gene	resistance|amod|START_ENTITY resistance|nmod|END_ENTITY	5-Azacytidine-induced 6-thioguanine resistance at the gpt locus in AS52 cells : cellular response .
22999992	0	6a-ethylchenodeoxycholic_acid	25,54	Farnesoid_X_Receptor	104,124	6a-ethylchenodeoxycholic acid	Farnesoid X Receptor	null	9971	Chemical	Gene	START_ENTITY|appos|agonist agonist|nmod|END_ENTITY	An improved synthesis of 6a-ethylchenodeoxycholic_acid -LRB- 6ECDCA -RRB- , a potent and selective agonist for the Farnesoid_X_Receptor -LRB- FXR -RRB- .
12166927	0	6alpha-ethyl-chenodeoxycholic_acid	0,34	FXR	69,72	6alpha-ethyl-chenodeoxycholic acid	FXR	MESH:C464660	60351(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	6alpha-ethyl-chenodeoxycholic_acid -LRB- 6-ECDCA -RRB- , a potent and selective FXR agonist endowed with anticholestatic activity .
21490593	0	6b-hydroxycortisone	34,53	CYP3A4	123,129	6b-hydroxycortisone	CYP3A4	null	1576	Chemical	Gene	Evaluation|nmod|START_ENTITY Evaluation|nmod|END_ENTITY	Evaluation of 6b-hydroxycortisol , 6b-hydroxycortisone , and a combination of the two as endogenous probes for inhibition of CYP3A4 in vivo .
23934209	0	7,8-Dihydroxyflavone	0,20	TrkB	24,28	7,8-Dihydroxyflavone	TrkB	MESH:C485383	18212(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	7,8-Dihydroxyflavone , a TrkB agonist , attenuates behavioral_abnormalities and neurotoxicity in mice after administration of methamphetamine .
24614170	0	7,8-Dihydroxyflavone	0,20	TrkB	39,43	7,8-Dihydroxyflavone	TrkB	MESH:C485383	18212(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	7,8-Dihydroxyflavone , a small molecule TrkB agonist , improves spatial memory and increases thin spine density in a mouse model of Alzheimer_disease-like_neuronal_loss .
25143381	0	7,8-Dihydroxyflavone	91,111	TrkB	149,153	7,8-Dihydroxyflavone	TrkB	MESH:C485383	4915	Chemical	Gene	Investigation|nmod|START_ENTITY Investigation|nmod|Receptor Receptor|compound|END_ENTITY	Biochemical and Biophysical Investigation of the Brain-derived Neurotrophic Factor Mimetic 7,8-Dihydroxyflavone in the Binding and Activation of the TrkB Receptor .
25415296	0	7,8-Dihydroxyflavone	27,47	TrkB	51,55	7,8-Dihydroxyflavone	TrkB	MESH:C485383	18212(Tax:10090)	Chemical	Gene	START_ENTITY|appos|Agonist Agonist|compound|END_ENTITY	Post-Injury Treatment with 7,8-Dihydroxyflavone , a TrkB Receptor Agonist , Protects against Experimental Traumatic_Brain_Injury via PI3K/Akt Signaling .
25754472	0	7,8-Dihydroxyflavone	59,79	TrkB	23,27	7,8-Dihydroxyflavone	TrkB	MESH:C485383	18212(Tax:10090)	Chemical	Gene	Sex-Dependently|amod|START_ENTITY END_ENTITY|nmod|Sex-Dependently	Activation of Muscular TrkB by its Small Molecular Agonist 7,8-Dihydroxyflavone Sex-Dependently Regulates Energy Metabolism in Diet-Induced Obese Mice .
26404256	0	7,8-Dihydroxyflavone	40,60	TrkB	86,90	7,8-Dihydroxyflavone	TrkB	MESH:C485383	4915	Chemical	Gene	Interactions|nmod|START_ENTITY Exploring|dobj|Interactions Exploring|nmod|Proteins Proteins|compound|END_ENTITY	Exploring the Molecular Interactions of 7,8-Dihydroxyflavone and Its Derivatives with TrkB and VEGFR2 Proteins .
1455607	0	7,8-benzoflavone	28,44	aryl_hydrocarbon_hydroxylase	48,76	7,8-benzoflavone	aryl hydrocarbon hydroxylase	MESH:C011512	13076(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	In vitro/in vivo effects of 7,8-benzoflavone on aryl_hydrocarbon_hydroxylase activity of mice .
2115161	0	7,8-benzoflavone	65,81	aryl_hydrocarbon_hydroxylase	85,113	7,8-benzoflavone	aryl hydrocarbon hydroxylase	MESH:C011512	1551	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	In vitro effects of methylsulfonyl_polychlorinated_biphenyls and 7,8-benzoflavone on aryl_hydrocarbon_hydroxylase activity in human lymphoblastoid cells .
7273297	0	7,8-benzoflavone	80,96	aryl_hydrocarbon_hydroxylase	30,58	7,8-benzoflavone	aryl hydrocarbon hydroxylase	MESH:C011512	1545	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|metabolites metabolites|nmod|END_ENTITY	Microsomal metabolites of the aryl_hydrocarbon_hydroxylase and tumour inhibitor 7,8-benzoflavone .
8430440	0	7,8-benzoflavone	18,34	aryl_hydrocarbon_hydroxylase	38,66	7,8-benzoflavone	aryl hydrocarbon hydroxylase	MESH:C011512	13076(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	In vivo effect of 7,8-benzoflavone on aryl_hydrocarbon_hydroxylase activity of mouse liver microsomes .
19161295	0	7,8-dihydro-8-oxoguanine	10,34	Dnmt3a	69,75	7,8-dihydro-8-oxoguanine	Dnmt3a	MESH:C453560	13435(Tax:10090)	Chemical	Gene	Impact|nmod|START_ENTITY Impact|nmod|END_ENTITY	Impact of 7,8-dihydro-8-oxoguanine on methylation of the CpG site by Dnmt3a .
25772829	0	7,8-dihydroneopterin	72,92	myoglobin	106,115	7,8-dihydroneopterin	myoglobin	MESH:C000976	4151	Chemical	Gene	oxidation|amod|START_ENTITY oxidation|nmod|END_ENTITY	Impact-induced muscle_damage and urinary pterins in professional rugby : 7,8-dihydroneopterin oxidation by myoglobin .
20133810	0	7,8-dihydroxyflavone	64,84	TrkB	12,16	7,8-dihydroxyflavone	TrkB	MESH:C485383	18212(Tax:10090)	Chemical	Gene	agonist|advcl|START_ENTITY agonist|nsubj|END_ENTITY	A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone .
21123312	0	7,8-dihydroxyflavone	10,30	TrkB	49,53	7,8-dihydroxyflavone	TrkB	MESH:C485383	18212(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Effect of 7,8-dihydroxyflavone , a small-molecule TrkB agonist , on emotional learning .
21136519	0	7,8-dihydroxyflavone	0,20	TrkB	24,28	7,8-dihydroxyflavone	TrkB	MESH:C485383	25054(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	7,8-dihydroxyflavone , a TrkB receptor agonist , blocks long-term spatial memory_impairment caused by immobilization stress in rats .
21900882	0	7,8-dihydroxyflavone	0,20	TrkB	39,43	7,8-dihydroxyflavone	TrkB	MESH:C485383	18212(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	7,8-dihydroxyflavone , a small-molecule TrkB agonist , reverses memory_deficits and BACE1 elevation in a mouse model of Alzheimer 's _ disease .
22246885	0	7,8-dihydroxyflavone	32,52	TrkB	10,14	7,8-dihydroxyflavone	TrkB	MESH:C485383	18212(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	The novel TrkB receptor agonist 7,8-dihydroxyflavone enhances neuromuscular transmission .
22710915	0	7,8-dihydroxyflavone	22,42	TrkB	14,18	7,8-dihydroxyflavone	TrkB	MESH:C485383	25054(Tax:10116)	Chemical	Gene	defects|amod|START_ENTITY END_ENTITY|nmod|defects	Activation of TrkB by 7,8-dihydroxyflavone prevents fear memory defects and facilitates amygdalar synaptic plasticity in aging .
22984948	0	7,8-dihydroxyflavone	68,88	TrkB	54,58	7,8-dihydroxyflavone	TrkB	MESH:C485383	18212(Tax:10090)	Chemical	Gene	models|amod|START_ENTITY agonist|dobj|models agonist|nsubj|Optimization Optimization|nmod|tropomyosin-related_kinase_B tropomyosin-related_kinase_B|appos|END_ENTITY	Optimization of a small tropomyosin-related_kinase_B -LRB- TrkB -RRB- agonist 7,8-dihydroxyflavone active in mouse models of depression .
23445871	0	7,8-dihydroxyflavone	27,47	TrkB	58,62	7,8-dihydroxyflavone	TrkB	MESH:C485383	18212(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	O-methylated metabolite of 7,8-dihydroxyflavone activates TrkB receptor and displays antidepressant activity .
23567067	0	7,8-dihydroxyflavone	54,74	TrkB	32,36	7,8-dihydroxyflavone	TrkB	MESH:C485383	18212(Tax:10090)	Chemical	Gene	agonist|xcomp|START_ENTITY agonist|nsubj|effects effects|nmod|receptor receptor|compound|END_ENTITY	Modulatory effects of the novel TrkB receptor agonist 7,8-dihydroxyflavone on synaptic transmission and intrinsic neuronal excitability in mouse visual cortex in vitro .
23567202	0	7,8-dihydroxyflavone	24,44	TrkB	11,15	7,8-dihydroxyflavone	TrkB	MESH:C485383	18212(Tax:10090)	Chemical	Gene	agonist|xcomp|START_ENTITY agonist|nsubj|Effects Effects|nmod|END_ENTITY	Effects of TrkB agonist 7,8-dihydroxyflavone on sensory gating deficits in mice after administration of methamphetamine .
24045895	0	7,8-dihydroxyflavone	0,20	TrkB	69,73	7,8-dihydroxyflavone	TrkB	MESH:C485383	25054(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|appos|END_ENTITY	7,8-dihydroxyflavone , a small-molecule tropomyosin-related_kinase_B -LRB- TrkB -RRB- agonist , attenuates cerebral_ischemia and reperfusion_injury in rats .
26740873	0	7,8-dihydroxyflavone	0,20	TrkB	40,44	7,8-dihydroxyflavone	TrkB	MESH:C485383	4915	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	7,8-dihydroxyflavone , a small molecular TrkB agonist , is useful for treating various BDNF-implicated human disorders .
26943953	0	7,8-dihydroxyflavone	14,34	TrkB	0,4	7,8-dihydroxyflavone	TrkB	MESH:C485383	18212(Tax:10090)	Chemical	Gene	agonist|amod|START_ENTITY agonist|amod|END_ENTITY	TrkB agonist , 7,8-dihydroxyflavone , reduces the clinical and pathological severity of a murine model of multiple_sclerosis .
27019033	0	7,8-dihydroxyflavone	0,20	TrkB	110,114	7,8-dihydroxyflavone	TrkB	MESH:C485383	25054(Tax:10116)	Chemical	Gene	protects|nsubj|START_ENTITY protects|dobj|neurons neurons|acl|degeneration degeneration|nmod|activation activation|nmod|END_ENTITY	7,8-dihydroxyflavone protects 6-OHDA and MPTP induced dopaminergic neurons degeneration through activation of TrkB in rodents .
22984948	0	7,8-dihydroxyflavone	68,88	tropomyosin-related_kinase_B	24,52	7,8-dihydroxyflavone	tropomyosin-related kinase B	MESH:C485383	18212(Tax:10090)	Chemical	Gene	models|amod|START_ENTITY agonist|dobj|models agonist|nsubj|Optimization Optimization|nmod|END_ENTITY	Optimization of a small tropomyosin-related_kinase_B -LRB- TrkB -RRB- agonist 7,8-dihydroxyflavone active in mouse models of depression .
24045895	0	7,8-dihydroxyflavone	0,20	tropomyosin-related_kinase_B	39,67	7,8-dihydroxyflavone	tropomyosin-related kinase B	MESH:C485383	25054(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	7,8-dihydroxyflavone , a small-molecule tropomyosin-related_kinase_B -LRB- TrkB -RRB- agonist , attenuates cerebral_ischemia and reperfusion_injury in rats .
15027848	0	7-Alkoxy-4-phenylamino-3-quinolinecar-bonitriles	0,48	Src	71,74	7-Alkoxy-4-phenylamino-3-quinolinecar-bonitriles	Src	null	6714	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	7-Alkoxy-4-phenylamino-3-quinolinecar-bonitriles as dual inhibitors of Src and Abl kinases .
9767654	0	7-Arylidenenaltrexones	0,22	delta1_opioid_receptor	36,58	7-Arylidenenaltrexones	delta1 opioid receptor	null	18386(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|antagonists antagonists|amod|END_ENTITY	7-Arylidenenaltrexones as selective delta1_opioid_receptor antagonists .
8383271	0	7-Benzylidenenaltrexone	0,23	delta_1_opioid_receptor	44,67	7-Benzylidenenaltrexone	delta 1 opioid receptor	MESH:C077358	18386(Tax:10090)	Chemical	Gene	START_ENTITY|dep|antagonist antagonist|amod|END_ENTITY	7-Benzylidenenaltrexone -LRB- BNTX -RRB- : a selective delta_1_opioid_receptor antagonist in the mouse spinal cord .
19684608	0	7-Chloroarctinone-b	0,19	PPARgamma	39,48	7-Chloroarctinone-b	PPARgamma	MESH:C544871	19016(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|antagonist antagonist|compound|END_ENTITY	7-Chloroarctinone-b as a new selective PPARgamma antagonist potently blocks adipocyte differentiation .
2832168	1	7-Hydroxyellipticine	110,130	cytochrome_P-450	162,178	7-Hydroxyellipticine	cytochrome P-450	MESH:C055440	13079(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|induction induction|amod|END_ENTITY	7-Hydroxyellipticine as a competitive antagonist of cytochrome_P-450 induction .
23770348	0	7-Ketocholesterol	0,17	Nox4	76,80	7-Ketocholesterol	Nox4	MESH:C003001	50507	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	7-Ketocholesterol induces autophagy in vascular smooth muscle cells through Nox4 and Atg4B .
23792120	0	7-Ketocholesterol	0,17	P-glycoprotein	26,40	7-Ketocholesterol	P-glycoprotein	MESH:C003001	5243	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	7-Ketocholesterol induces P-glycoprotein through PI3K/mTOR signaling in hepatoma cells .
18515973	0	7-Ketocholesterol	0,17	interleukin-6	30,43	7-Ketocholesterol	interleukin-6	MESH:C003001	3569	Chemical	Gene	upregulates|amod|START_ENTITY upregulates|amod|END_ENTITY	7-Ketocholesterol upregulates interleukin-6 via mechanisms that are distinct from those of tumor_necrosis_factor-alpha , in vascular smooth muscle cells .
24642088	0	7-Ketocholesterol	0,17	isocitrate_dehydrogenase_2	27,53	7-Ketocholesterol	isocitrate dehydrogenase 2	MESH:C003001	3418	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	7-Ketocholesterol inhibits isocitrate_dehydrogenase_2 expression and impairs endothelial function via microRNA-144 .
25306252	0	7-Nitroindazole	0,15	c-Fos	25,30	7-Nitroindazole	c-Fos	MESH:C080122	314322(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	7-Nitroindazole enhances c-Fos expression in spinal neurons in rats realizing operant movements .
22431094	0	7-Nitroindazole	0,15	c-fos	28,33	7-Nitroindazole	c-fos	MESH:C080122	314322(Tax:10116)	Chemical	Gene	potentiates|amod|START_ENTITY END_ENTITY|nsubj|potentiates	7-Nitroindazole potentiates c-fos expression induced by muscle tendon vibration in the spinal cord .
10519054	0	7-Nitroindazole	0,15	nNOS	42,46	7-Nitroindazole	nNOS	MESH:C080122	24598(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	7-Nitroindazole , a selective inhibitor of nNOS , increases hippocampal extracellular glutamate concentration in status_epilepticus induced by kainic_acid in rats .
11129101	0	7-Nitroindazole	0,15	nitric_oxide_synthase	19,40	7-Nitroindazole	nitric oxide synthase	MESH:C080122	18125(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	7-Nitroindazole , a nitric_oxide_synthase inhibitor , enhances the anticonvulsive action of ethosuximide and clonazepam against pentylenetetrazol-induced convulsions .
8891246	0	7-OH-DPAT	35,44	D2_and_D1	0,9	7-OH-DPAT	D2 and D1	MESH:C031349	29484(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	D2_and_D1 dopaminergic activity of 7-OH-DPAT .
7799531	0	7-OH-DPAT	22,31	dopamine_D3-receptor	33,53	7-OH-DPAT	dopamine D3-receptor	MESH:C031349	29238(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Inhibitory effects of 7-OH-DPAT , dopamine_D3-receptor agonist , on nucleus accumbens neurons .
8761030	0	7-OH-DPAT	31,40	dopamine_D3-receptor	44,64	7-OH-DPAT	dopamine D3-receptor	MESH:C031349	13490(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY Modification|nmod|effects Modification|appos|agonist agonist|amod|END_ENTITY	Modification of the effects of 7-OH-DPAT , a dopamine_D3-receptor agonist , on morphine-induced hyperlocomotion by diabetes .
7667384	0	7-OH-DPAT	43,52	dopamine_D3_receptor	15,35	7-OH-DPAT	dopamine D3 receptor	MESH:C031349	29238(Tax:10116)	Chemical	Gene	ligand|dobj|START_ENTITY ligand|nsubj|Effects Effects|nmod|END_ENTITY	Effects of the dopamine_D3_receptor ligand 7-OH-DPAT on male rat ejaculatory behavior .
18930653	0	7-alkoxy-4-heteroarylamino-3-cyanoquinolines	51,95	c-Src	118,123	7-alkoxy-4-heteroarylamino-3-cyanoquinolines	c-Src	null	6714	Chemical	Gene	evaluation|nmod|START_ENTITY evaluation|nmod|END_ENTITY	The design , synthesis and biological evaluation of 7-alkoxy-4-heteroarylamino-3-cyanoquinolines as dual inhibitors of c-Src and iNOS .
23994329	0	7-azaindazolyl-indolyl-maleimides	36,69	glycogen_synthase_kinase-3b	73,100	7-azaindazolyl-indolyl-maleimides	glycogen synthase kinase-3b	null	2932	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Design , synthesis and evaluation of 7-azaindazolyl-indolyl-maleimides as glycogen_synthase_kinase-3b -LRB- GSK-3b -RRB- inhibitors .
24884406	0	7-azaindole	129,140	glycogen_synthase_kinase-3b	156,183	7-azaindole	glycogen synthase kinase-3b	MESH:C023422	2932	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Binding free-energy calculation is a powerful tool for drug optimization : calculation and measurement of binding free energy for 7-azaindole derivatives to glycogen_synthase_kinase-3b .
19945871	0	7-azaindoles	68,80	JAK2	108,112	7-azaindoles	JAK2	null	3717	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	A novel chemotype of kinase inhibitors : Discovery of 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitors .
10548061	0	7-azido-4-methylcoumarin	104,128	SULT1A1	94,101	7-azido-4-methylcoumarin	SULT1A1	MESH:C097886	6817	Chemical	Gene	sulfotransferase|amod|START_ENTITY sulfotransferase|appos|END_ENTITY	Photoaffinity labeling probe for the substrate binding site of human phenol sulfotransferase -LRB- SULT1A1 -RRB- : 7-azido-4-methylcoumarin .
2384754	0	7-chloro-4-nitrobenzofurazan	35,63	monoamine_oxidase	14,31	7-chloro-4-nitrobenzofurazan	monoamine oxidase	MESH:D009327	29253(Tax:10116)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of monoamine_oxidase by 7-chloro-4-nitrobenzofurazan .
25017465	0	7-dehydrocholesterol	13,33	cytochrome_P450_46A1	59,79	7-dehydrocholesterol	cytochrome P450 46A1	MESH:C016705	10858	Chemical	Gene	Oxidation|acl|START_ENTITY Oxidation|nmod|END_ENTITY	Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome_P450_46A1 .
8504082	0	7-ethoxycoumarin	95,111	cytochrome_P450_1A2	44,63	7-ethoxycoumarin	cytochrome P450 1A2	MESH:C017299	1544	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of mutations of ionic amino_acids of cytochrome_P450_1A2 on catalytic activities toward 7-ethoxycoumarin and methanol .
14577217	0	7-ethoxyresorufin	75,92	CYP1A1	43,49	7-ethoxyresorufin	CYP1A1	CHEBI:34480	1543	Chemical	Gene	analysis|nmod|START_ENTITY analysis|nmod|END_ENTITY	Enzymatic analysis of cDNA-expressed human CYP1A1 , CYP1A2 , and CYP1B1 with 7-ethoxyresorufin as substrate .
16719376	0	7-ethoxyresorufin	75,92	CYP1A1	43,49	7-ethoxyresorufin	CYP1A1	CHEBI:34480	1543	Chemical	Gene	analysis|nmod|START_ENTITY analysis|nmod|END_ENTITY	Enzymatic analysis of cDNA-expressed human CYP1A1 , CYP1A2 , and CYP1B1 with 7-ethoxyresorufin as substrate .
11688982	0	7-ethyl-10-hydroxycamptothecin	13,43	ABCG2	88,93	7-ethyl-10-hydroxycamptothecin	ABCG2	MESH:C051890	9429	Chemical	Gene	Transport|nmod|START_ENTITY Transport|nmod|END_ENTITY	Transport of 7-ethyl-10-hydroxycamptothecin -LRB- SN-38 -RRB- by breast_cancer_resistance_protein ABCG2 in human lung_cancer cells .
12181437	0	7-ethyl-10-hydroxycamptothecin	92,122	UGT1A	13,18	7-ethyl-10-hydroxycamptothecin	UGT1A	MESH:C051890	7361	Chemical	Gene	polymorphisms|amod|START_ENTITY polymorphisms|compound|END_ENTITY	Common human UGT1A polymorphisms and the altered metabolism of irinotecan active metabolite 7-ethyl-10-hydroxycamptothecin -LRB- SN-38 -RRB- .
17188862	0	7-ethynyl-4-phenylamino-3-quinolinecarbonitriles	37,85	Src	14,17	7-ethynyl-4-phenylamino-3-quinolinecarbonitriles	Src	null	6714	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Inhibition of Src kinase activity by 7-ethynyl-4-phenylamino-3-quinolinecarbonitriles : identification of SKS-927 .
19171483	0	7-isothiocyanatotetrahydroisoquinoline	79,117	phenylethanolamine_N-methyltransferase	37,75	7-isothiocyanatotetrahydroisoquinoline	phenylethanolamine N-methyltransferase	MESH:C538959	5409	Chemical	Gene	inactivation|nmod|START_ENTITY inactivation|nmod|END_ENTITY	Time-dependent inactivation of human phenylethanolamine_N-methyltransferase by 7-isothiocyanatotetrahydroisoquinoline .
10869358	0	7-ketocholesterol	30,47	Sterol_27-hydroxylase	0,21	7-ketocholesterol	Sterol 27-hydroxylase	MESH:C003001	1593	Chemical	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	Sterol_27-hydroxylase acts on 7-ketocholesterol in human atherosclerotic_lesions and macrophages in culture .
20424663	0	7-ketocholesterol	0,17	nuclear_factor_kappa_B	58,80	7-ketocholesterol	nuclear factor kappa B	MESH:C003001	18033(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	7-ketocholesterol induces cell apoptosis by activation of nuclear_factor_kappa_B in mouse macrophages .
24814410	0	7-ketocholesteryl-9-carboxynonanoate	0,36	ATP_binding_cassette_transporter_A1	46,81	7-ketocholesteryl-9-carboxynonanoate	ATP binding cassette transporter A1	MESH:C510905	19	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	7-ketocholesteryl-9-carboxynonanoate enhances ATP_binding_cassette_transporter_A1 expression mediated by PPARy in THP-1 macrophages .
18367715	2	7-methyl_guanosine	320,338	eIF4E	311,316	7-methyl guanosine	eIF4G	MESH:C016578	1981	Chemical	Gene	protein|amod|START_ENTITY END_ENTITY|appos|protein	eIF4F is a heterotrimeric complex composed of three subunits : eIF4E , a 7-methyl_guanosine cap binding protein ; eIF4A , a DEAD-box RNA helicase ; and eIF4G .
19933321	0	7-methyl_guanosine	59,77	eIF4E	49,54	7-methyl guanosine	eIF4E	MESH:C016578	399255(Tax:8355)	Chemical	Gene	recognition|amod|START_ENTITY END_ENTITY|nmod|recognition	Pumilio_2 controls translation by competing with eIF4E for 7-methyl_guanosine cap recognition .
18449627	0	7-monohydroxyethyl_rutoside	94,121	CBR1	54,58	7-monohydroxyethyl rutoside	CBR1	MESH:C522803	873	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of polymorphic human carbonyl_reductase_1 -LRB- CBR1 -RRB- by the cardioprotectant flavonoid 7-monohydroxyethyl_rutoside -LRB- monoHER -RRB- .
18449627	0	7-monohydroxyethyl_rutoside	94,121	carbonyl_reductase_1	32,52	7-monohydroxyethyl rutoside	carbonyl reductase 1	MESH:C522803	873	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of polymorphic human carbonyl_reductase_1 -LRB- CBR1 -RRB- by the cardioprotectant flavonoid 7-monohydroxyethyl_rutoside -LRB- monoHER -RRB- .
9668670	0	7-nitroindazole	11,26	NOS	31,34	7-nitroindazole	NOS	MESH:C080122	18125(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Effects of 7-nitroindazole , an NOS inhibitor on methamphetamine-induced dopaminergic and serotonergic neurotoxicity in mice .
18164516	0	7-nitroindazole	171,186	monoamine_oxidase-B	140,159	7-nitroindazole	monoamine oxidase-B	MESH:C080122	109731(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	In vitro and in vivo evidences that antioxidant action contributes to the neuroprotective effects of the neuronal nitric_oxide synthase and monoamine_oxidase-B inhibitor , 7-nitroindazole .
15517430	0	7-nitroindazole	0,15	nNOS	17,21	7-nitroindazole	nNOS	MESH:C080122	24598(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	7-nitroindazole , nNOS inhibitor , attenuates amphetamine-induced amino_acid release and nitric_oxide generation but not lipid peroxidation in the rat brain .
17300699	5	7-nitroindazole	896,911	nNOS	767,771	7-nitroindazole	nNOS	MESH:C080122	24598(Tax:10116)	Chemical	Gene	presence|nmod|START_ENTITY removed|nmod|presence removed|advcl|determine determine|dobj|role role|nmod|END_ENTITY	To determine the role of nNOS , we removed endothelial layer and measured contractile response and nitric_oxide -LRB- NO -RRB- release in the presence or absence of 7-nitroindazole -LRB- 7-NI , 10 muM -RRB- , an nNOS-specific inhibitor .
17922909	6	7-nitroindazole	1051,1066	nNOS	1103,1107	7-nitroindazole	nNOS	MESH:C080122	18125(Tax:10090)	Chemical	Gene	injection|nmod|START_ENTITY injection|appos|inhibitor inhibitor|compound|END_ENTITY	Intrathecal injection of 7-nitroindazole -LRB- 8.15 microg/5 microl -RRB- , a selective nNOS inhibitor , also dramatically attenuated_nerve_injury-induced mechanical hypersensitivity .
9729355	0	7-nitroindazole	11,26	nNOS	62,66	7-nitroindazole	nNOS	MESH:C080122	24598(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|appos|END_ENTITY	Effects of 7-nitroindazole , a neuronal nitric_oxide synthase -LRB- nNOS -RRB- inhibitor , on locomotor activity and contextual fear conditioning in rats .
11373254	0	7-nitroindazole	51,66	nitric_oxide_synthase	19,40	7-nitroindazole	nitric oxide synthase	MESH:C080122	18125(Tax:10090)	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|effects effects|nmod|END_ENTITY	The effects of the nitric_oxide_synthase inhibitor 7-nitroindazole on the behaviour of mice after chronic ethanol administration .
8821044	0	7-nitroindazole	62,77	nitric_oxide_synthase	104,125	7-nitroindazole	nitric oxide synthase	MESH:C080122	4843	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	NMDA-mediated toxicity to striatal neurons is not reversed by 7-nitroindazole , an inhibitor of neuronal nitric_oxide_synthase .
8858965	0	7-nitroindazole	46,61	nitric_oxide_synthase	13,34	7-nitroindazole	nitric oxide synthase	MESH:C080122	18125(Tax:10090)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	The neuronal nitric_oxide_synthase inhibitor , 7-nitroindazole , protects against methamphetamine-induced neurotoxicity in vivo .
9121609	0	7-nitroindazole	35,50	nitric_oxide_synthase	74,95	7-nitroindazole	nitric oxide synthase	MESH:C080122	18125(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Attenuation of cocaine kindling by 7-nitroindazole , an inhibitor of brain nitric_oxide_synthase .
9804111	0	7-nitroindazole	42,57	nitric_oxide_synthase	9,30	7-nitroindazole	nitric oxide synthase	MESH:C080122	18125(Tax:10090)	Chemical	Gene	motoneuron_degeneration|compound|START_ENTITY inhibitor|appos|motoneuron_degeneration inhibitor|compound|END_ENTITY	Neuronal nitric_oxide_synthase inhibitor , 7-nitroindazole , delays_motor_dysfunction and spinal motoneuron_degeneration in the wobbler mouse .
204962	0	7-oxa-13_prostynoic_acid	14,38	bradykinin	69,79	7-oxa-13 prostynoic acid	bradykinin	MESH:C031129	3827	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of 7-oxa-13_prostynoic_acid on the mechanism of action of bradykinin in human synovial fibroblasts .
22999639	0	7-oxysterol	77,88	Egr1	14,18	7-oxysterol	Egr1	null	1958	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Expression Expression|nmod|END_ENTITY	Expression of Egr1 and p53 in human carotid plaques and apoptosis induced by 7-oxysterol or p53 .
23007316	0	7-substituted_camptothecin_Namitecan	36,72	ST1968	74,80	7-substituted camptothecin Namitecan	ST1968	null	1460028(Tax:273063)	Chemical	Gene	evaluation|nmod|START_ENTITY evaluation|appos|END_ENTITY	Preclinical evaluation of the novel 7-substituted_camptothecin_Namitecan -LRB- ST1968 -RRB- in paediatric_tumour models .
16973597	0	709-amino-acid	20,34	UL36	115,119	709-amino-acid	UL36	null	2703357(Tax:10298)	Chemical	Gene	region|amod|START_ENTITY region|nmod|END_ENTITY	Identification of a 709-amino-acid internal nonessential region within the essential conserved tegument protein -LRB- p -RRB- UL36 of pseudorabies_virus .
20219980	0	7alpha-hydroxypregnenolone	37,63	Prolactin	0,9	7alpha-hydroxypregnenolone	Prolactin	MESH:C495856	5617	Chemical	Gene	synthesis|nmod|START_ENTITY increases|dobj|synthesis increases|nsubj|END_ENTITY	Prolactin increases the synthesis of 7alpha-hydroxypregnenolone , a key factor for induction of locomotor activity , in breeding male Newts .
19893321	0	7b-hydroxycholesterol	65,86	ERK	118,121	7b-hydroxycholesterol	ERK	null	5594	Chemical	Gene	START_ENTITY|nmod|cells cells|nmod|END_ENTITY	Antiapoptotic and proliferative effects of low concentrations of 7b-hydroxycholesterol in human endothelial cells via ERK activation .
18317936	0	7beta-Hydroxycholesterol	0,24	interleukin-8	59,72	7beta-Hydroxycholesterol	interleukin-8	MESH:C011724	3576	Chemical	Gene	secretion|amod|START_ENTITY secretion|amod|END_ENTITY	7beta-Hydroxycholesterol and 25-hydroxycholesterol-induced interleukin-8 secretion involves a calcium-dependent activation of c-fos via the ERK1/2 signaling pathway in THP-1 cells : oxysterols-induced IL-8 secretion is calcium-dependent .
3120506	0	8-Amino-9-substituted_guanines	0,30	purine_nucleoside_phosphorylase	39,70	8-Amino-9-substituted guanines	purine nucleoside phosphorylase	null	4860	Chemical	Gene	START_ENTITY|dep|inhibitors inhibitors|compound|END_ENTITY	8-Amino-9-substituted_guanines : potent purine_nucleoside_phosphorylase -LRB- PNP -RRB- inhibitors .
12182866	0	8-Aryl_xanthines	0,16	phosphodiesterase_5	38,57	8-Aryl xanthines	phosphodiesterase 5	null	8654	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	8-Aryl_xanthines potent inhibitors of phosphodiesterase_5 .
7873550	0	8-Azido-ATP	0,11	cytochrome_c	28,40	8-Azido-ATP	cytochrome c	MESH:C017040	104968582	Chemical	Gene	modification|amod|START_ENTITY modification|nmod|END_ENTITY	8-Azido-ATP modification of cytochrome_c : retardation of its electron-transfer activity to cytochrome_c oxidase .
18678488	0	8-Biarylchromen-4-one	0,21	DNA-dependent_protein_kinase	40,68	8-Biarylchromen-4-one	DNA-dependent protein kinase	null	5591	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	8-Biarylchromen-4-one inhibitors of the DNA-dependent_protein_kinase -LRB- DNA-PK -RRB- .
23425137	0	8-BuS-ATP	0,9	NTPDase1	34,42	8-BuS-ATP	NTPDase1	null	953	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	8-BuS-ATP derivatives as specific NTPDase1 inhibitors .
11852070	0	8-Chloro-dGTP	0,13	hMTH1	73,78	8-Chloro-dGTP	hMTH1	MESH:C450421	4521	Chemical	Gene	hydrolyzed|nsubjpass|START_ENTITY hydrolyzed|nmod|END_ENTITY	8-Chloro-dGTP , a hypochlorous_acid-modified nucleotide , is hydrolyzed by hMTH1 , the human MutT homolog .
15052360	0	8-MOP	14,19	TNF-alpha	58,67	8-MOP	TNF-alpha	MESH:D008730	7124	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|release release|nmod|END_ENTITY	UVA activated 8-MOP and chlorpromazine inhibit release of TNF-alpha by post-transcriptional regulation .
21475870	0	8-Methoxypsoralen	0,17	CYP2A6	34,40	8-Methoxypsoralen	CYP2A6	MESH:D008730	1548	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	8-Methoxypsoralen , a potent human CYP2A6 inhibitor , inhibits lung_adenocarcinoma development induced by 4 - -LRB- methylnitrosamino -RRB- -1 - -LRB- 3-pyridyl -RRB- -1 - butanone in female A/J mice .
25324722	0	8-Methoxypsoralen	0,17	P1-1	74,78	8-Methoxypsoralen	P1-1	MESH:D008730	6281	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	8-Methoxypsoralen is a competitive inhibitor of glutathione_S-transferase P1-1 .
13679077	0	8-Nitroxanthine	0,15	myeloperoxidase	30,45	8-Nitroxanthine	myeloperoxidase	MESH:C432525	4353	Chemical	Gene	START_ENTITY|appos|product product|nmod|END_ENTITY	8-Nitroxanthine , a product of myeloperoxidase , peroxynitrite , and activated human neutrophils , enhances generation of superoxide by xanthine oxidase .
26030662	0	8-O-Demethylmaritidine	31,53	Acetylcholinesterase	72,92	8-O-Demethylmaritidine	Acetylcholinesterase	MESH:C459635	43	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	In Vitro Inhibitory Effects of 8-O-Demethylmaritidine and Undulatine on Acetylcholinesterase and Their Predicted Penetration across the Blood-Brain Barrier .
10607047	0	8-OH-DPAT	54,63	5-HT1A	30,36	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	agonist|dobj|START_ENTITY agonist|nsubj|effects effects|nmod|receptor receptor|nummod|END_ENTITY	Dose-dependent effects of the 5-HT1A receptor agonist 8-OH-DPAT on sleep and wakefulness in the rat .
11769569	0	8-OH-DPAT	35,44	5-HT1A	10,16	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	agonist|amod|START_ENTITY agonist|nummod|END_ENTITY	Selective 5-HT1A receptor agonist , 8-OH-DPAT , locally administered into the dorsal raphe nucleus increased extracellular acetylcholine concentrations in the medial prefrontal cortex of conscious rats .
11817498	0	8-OH-DPAT	73,82	5-HT1A	8,14	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	study|amod|START_ENTITY Role|dep|study Role|nmod|receptors receptors|nummod|END_ENTITY	Role of 5-HT1A receptors in the mediation of acute citalopram effects : a 8-OH-DPAT challenge study .
12237750	0	8-OH-DPAT	84,93	5-HT1A	64,70	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	receptors|nmod|START_ENTITY receptors|nummod|END_ENTITY	Prolonged corticosterone treatment alters the responsiveness of 5-HT1A receptors to 8-OH-DPAT in rat CA1 hippocampal neurons .
12552358	0	8-OH-DPAT	19,28	5-HT1A	4,10	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	dose-dependently|nummod|START_ENTITY dose-dependently|nummod|END_ENTITY	The 5-HT1A agonist 8-OH-DPAT dose-dependently interferes with the establishment and the expression of lithium-induced conditioned rejection reactions in rats .
12611395	0	8-OH-DPAT	24,33	5-HT1A	0,6	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	acts|nummod|START_ENTITY agonist|dobj|acts agonist|nsubj|receptor receptor|nummod|END_ENTITY	5-HT1A receptor agonist 8-OH-DPAT acts in the hindbrain to reverse the sympatholytic response to severe hemorrhage .
1359515	1	8-OH-DPAT	196,205	5-HT1A	181,187	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	agonist|nummod|START_ENTITY agonist|nummod|END_ENTITY	A comparison with the 5-HT1A agonist 8-OH-DPAT .
1425937	0	8-OH-DPAT	35,44	5-HT1A	94,100	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|studies studies|nmod|BMY_7378 BMY_7378|amod|END_ENTITY	Discriminative stimulus effects of 8-OH-DPAT in pigeons : antagonism studies with the putative 5-HT1A receptor antagonists BMY_7378 and NAN-190 .
1436390	0	8-OH-DPAT	69,78	5-HT1A	19,25	8-OH-DPAT	5-HT1A	MESH:D017371	3350	Chemical	Gene	administration|nmod|START_ENTITY autoreceptors|nmod|administration autoreceptors|nsubj|Desensitization Desensitization|nmod|END_ENTITY	Desensitization of 5-HT1A autoreceptors by chronic administration of 8-OH-DPAT .
1448492	0	8-OH-DPAT	71,80	5-HT1A	55,61	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	agonist|amod|START_ENTITY agonist|amod|END_ENTITY	Estradiol modulation of the hyperphagia induced by the 5-HT1A agonist , 8-OH-DPAT .
14614949	0	8-OH-DPAT	57,66	5-HT1A	30,36	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	agonism|nmod|START_ENTITY agonism|nummod|END_ENTITY	Contribution of the serotonin 5-HT1A receptor agonism of 8-OH-DPAT and EMD_128130 to the regulation of haloperidol-induced muscle_rigidity in rats .
1482760	0	8-OH-DPAT	30,39	5-HT1A	15,21	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	agonist|nummod|START_ENTITY agonist|nummod|END_ENTITY	Effects of the 5-HT1A agonist 8-OH-DPAT on food intake in food-deprived rats .
14979803	0	8-OH-DPAT	60,69	5-HT1A	45,51	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	agonist|nummod|START_ENTITY agonist|nummod|END_ENTITY	Memory reactivation in rats treated with the 5-HT1A agonist 8-OH-DPAT : a case of gone , but not forgotten .
15014926	0	8-OH-DPAT	50,59	5-HT1A	29,35	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	agonist|dep|START_ENTITY injection|dep|agonist injection|nmod|END_ENTITY	Intraseptal injection of the 5-HT1A / 5-HT7 agonist 8-OH-DPAT and working memory in rats .
15033384	0	8-OH-DPAT	0,9	5-HT1A	23,29	8-OH-DPAT	5-HT1A	MESH:D017371	15550(Tax:10090)	Chemical	Gene	acts|nummod|START_ENTITY acts|nmod|END_ENTITY	8-OH-DPAT acts on both 5-HT1A and 5-HT7 receptors to induce hypothermia in rodents .
15589388	0	8-OH-DPAT	99,108	5-HT1A	0,6	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY involved|nmod|effects involved|nsubjpass|receptors receptors|nummod|END_ENTITY	5-HT1A receptors are differentially involved in the anxiolytic - and antidepressant-like effects of 8-OH-DPAT and fluoxetine in the rat .
15830225	0	8-OH-DPAT	83,92	5-HT1A	173,179	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	tetralin|appos|START_ENTITY Comparison|dep|tetralin Comparison|dep|evidence evidence|nmod|involvement involvement|nmod|receptors receptors|nummod|END_ENTITY	Comparison of the effects of clozapine and 8-hydroxy-2 - -LRB- di-n-propylamino -RRB- tetralin -LRB- 8-OH-DPAT -RRB- on progressive ratio schedule performance : evidence against the involvement of 5-HT1A receptors in the behavioural effects of clozapine .
16796994	0	8-OH-DPAT	21,30	5-HT1A	52,58	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	Stereoselectivity|nmod|START_ENTITY Stereoselectivity|nmod|receptor receptor|nummod|END_ENTITY	Stereoselectivity of 8-OH-DPAT toward the serotonin 5-HT1A receptor : biochemical and molecular modeling study .
1682325	0	8-OH-DPAT	22,31	5-HT1A	115,121	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|evidence evidence|nmod|involvement involvement|nmod|receptors receptors|nummod|END_ENTITY	Vasodilator effect of 8-OH-DPAT in the isolated perfused mesenteric bed of the rat : no evidence for involvement of 5-HT1A receptors .
16836640	0	8-OH-DPAT	88,97	5-HT1A	23,29	8-OH-DPAT	5-HT1A	MESH:D017371	15550(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Contribution Contribution|nmod|END_ENTITY	Contribution of spinal 5-HT1A and 5-HT7 receptors to locomotor-like movement induced by 8-OH-DPAT in spinal cord-transected mice .
1688708	0	8-OH-DPAT	123,132	5-HT1A	108,114	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	agonist|nummod|START_ENTITY agonist|nummod|END_ENTITY	Hippocampal 5-hydroxytryptamine synthesis is greater in female rats than in males and more decreased by the 5-HT1A agonist 8-OH-DPAT .
17202670	0	8-OH-DPAT	34,43	5-HT1A	120,126	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	agonist|amod|START_ENTITY inhibits|nsubj|agonist inhibits|parataxis|shakes shakes|nsubj|involvement involvement|nmod|receptors receptors|nummod|END_ENTITY	The 5-HT1A receptor full agonist , 8-OH-DPAT inhibits ACTH-induced 5-HT2A receptor hyperfunction in rats : involvement of 5-HT1A receptors in the DOI-induced wet-dog shakes in ACTH-treated rats .
17202670	0	8-OH-DPAT	34,43	5-HT1A	4,10	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	agonist|amod|START_ENTITY agonist|amod|full full|nmod:npmod|receptor receptor|nummod|END_ENTITY	The 5-HT1A receptor full agonist , 8-OH-DPAT inhibits ACTH-induced 5-HT2A receptor hyperfunction in rats : involvement of 5-HT1A receptors in the DOI-induced wet-dog shakes in ACTH-treated rats .
1826841	0	8-OH-DPAT	45,54	5-HT1A	0,6	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY agonists|dep|effects agonists|nummod|END_ENTITY	5-HT1A agonists and dopamine : the effects of 8-OH-DPAT and buspirone on brain-stimulation reward .
1826937	0	8-OH-DPAT	38,47	5-HT1A	14,20	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	agonist|dobj|START_ENTITY agonist|nsubj|Effect Effect|nmod|receptor receptor|nummod|END_ENTITY	Effect of the 5-HT1A receptor agonist 8-OH-DPAT on the release of 5-HT in dorsal and median raphe-innervated rat brain regions as measured by in vivo microdialysis .
1835441	0	8-OH-DPAT	12,21	5-HT1A	104,110	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	pretreatment|nummod|START_ENTITY induce|nsubj|pretreatment induce|nmod|effect effect|nmod|agonists agonists|nummod|END_ENTITY	Single-dose 8-OH-DPAT pretreatment does not induce tachyphylaxis to the 5-HT release-reducing effect of 5-HT1A autoreceptor agonists .
1838412	0	8-OH-DPAT	31,40	5-HT1A	15,21	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	agonist|amod|START_ENTITY agonist|amod|END_ENTITY	Effects of the 5-HT1A agonist , 8-OH-DPAT , on sexual behaviors of the proestrous rat .
1839148	0	8-OH-DPAT	41,50	5-HT1A	17,23	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	behavior|nummod|START_ENTITY agonist|dobj|behavior agonist|nsubj|doses doses|nmod|receptor receptor|nummod|END_ENTITY	Low doses of the 5-HT1A receptor agonist 8-OH-DPAT increase ingestive behavior in late preweanling and postweanling , but not neonatal rat pups .
1840083	0	8-OH-DPAT	75,84	5-HT1A	60,66	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	agonist|nummod|START_ENTITY agonist|nummod|END_ENTITY	Gender and estrous cycle differences in the response to the 5-HT1A agonist 8-OH-DPAT .
1970616	0	8-OH-DPAT	83,92	5-HT1A	14,20	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY involved|nmod|effects involved|nsubjpass|Evidence Evidence|nmod|receptors receptors|nummod|END_ENTITY	Evidence that 5-HT1A receptors are involved in the adrenaline-releasing effects of 8-OH-DPAT in the conscious rat .
1983358	0	8-OH-DPAT	51,60	5-HT1A	35,41	8-OH-DPAT	5-HT1A	MESH:D017371	15550(Tax:10090)	Chemical	Gene	effects|appos|START_ENTITY effects|nmod|ligands ligands|nummod|END_ENTITY	Anxiolytic and sedative effects of 5-HT1A ligands , 8-OH-DPAT and MDL 73005EF , in mice .
2138087	0	8-OH-DPAT	21,30	5-HT1A	34,40	8-OH-DPAT	5-HT1A	MESH:D017371	100301563(Tax:10141)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Different effects of 8-OH-DPAT , a 5-HT1A receptor agonist , on cortical acetylcholine release , electrocortigram and body temperature in guinea_pigs and rats .
2141988	0	8-OH-DPAT	30,39	5-HT1A	43,49	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Antidepressant-like action of 8-OH-DPAT , a 5-HT1A agonist , in the learned helplessness paradigm : evidence for a postsynaptic mechanism .
2142096	0	8-OH-DPAT	96,105	5-HT1A	48,54	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	that|nmod|START_ENTITY agonist|nmod|that agonist|nsubj|Comparison Comparison|nmod|effects effects|nmod|receptor receptor|nummod|END_ENTITY	Comparison of the cardiovascular effects of the 5-HT1A receptor agonist flesinoxan with that of 8-OH-DPAT in the rat .
22158750	0	8-OH-DPAT	20,29	5-HT1A	4,10	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	anorexia|amod|START_ENTITY agonists|dobj|anorexia agonists|nsubj|END_ENTITY	The 5-HT1A agonists 8-OH-DPAT , buspirone and ipsapirone_attenuate stress-induced anorexia in rats .
24570834	0	8-OH-DPAT	0,9	5-HT1A	11,17	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|nummod|END_ENTITY	8-OH-DPAT -LRB- 5-HT1A agonist -RRB- Attenuates 6-Hydroxy - dopamine-induced catalepsy and Modulates Inflammatory Cytokines in Rats .
2527161	0	8-OH-DPAT	70,79	5-HT1A	55,61	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	agonist|nummod|START_ENTITY agonist|nummod|END_ENTITY	Median raphe , but not dorsal raphe , application of the 5-HT1A agonist 8-OH-DPAT stimulates rat motor activity .
2530590	0	8-OH-DPAT	121,130	5-HT1A	57,63	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	tetralin|appos|START_ENTITY Stimulation|dep|tetralin Stimulation|nmod|secretion secretion|nmod|receptor receptor|amod|selective selective|dep|END_ENTITY	Stimulation of corticosterone secretion by the selective 5-HT1A receptor agonist 8-hydroxy-2 - -LRB- di-n-propylamino -RRB- tetralin -LRB- 8-OH-DPAT -RRB- in the rat .
2533334	0	8-OH-DPAT	52,61	5-HT1A	36,42	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	agonist|amod|START_ENTITY agonist|amod|END_ENTITY	Apparent hyperalgesic action of the 5-HT1A agonist , 8-OH-DPAT , in the rat reflects induction of spontaneous tail-flicks .
2533557	0	8-OH-DPAT	76,85	5-HT1A	21,27	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	stereoselective|dep|START_ENTITY analogue|amod|stereoselective properties|nmod|analogue properties|amod|END_ENTITY	Partial postsynaptic 5-HT1A agonist properties of the novel stereoselective 8-OH-DPAT analogue -LRB- + -RRB- cis-8-hydroxy-1-methyl-2 - -LRB- di-n-propylamino -RRB- tetralin , -LRB- + -RRB- ALK-3 .
2881789	0	8-OH-DPAT	96,105	5-HT1A	123,129	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	tetralin|appos|START_ENTITY tetralin|nmod|receptor receptor|amod|END_ENTITY	Mediation of the discriminative stimulus properties of 8-hydroxy-2 - -LRB- di-n-propylamino -RRB- _ tetralin -LRB- 8-OH-DPAT -RRB- by the putative 5-HT1A receptor .
2894736	0	8-OH-DPAT	24,33	5-HT1A	37,43	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY -LSB-|dobj|effects -RSB-|advcl|-LSB- -RSB-|nsubj|agonist agonist|amod|END_ENTITY	-LSB- Behavioural effects of 8-OH-DPAT , a 5-HT1A agonist in rats and effects on the behaviour of antimanic drugs -RSB- .
2949333	0	8-OH-DPAT	81,90	5-HT1A	34,40	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	produced|nmod|START_ENTITY produced|nsubj|enhancement enhancement|nmod|lithium lithium|nmod|serotonin_syndrome serotonin_syndrome|nummod|END_ENTITY	The enhancement by lithium of the 5-HT1A mediated serotonin_syndrome produced by 8-OH-DPAT in the rat : evidence for a post-synaptic mechanism .
2954178	0	8-OH-DPAT	143,152	5-HT1A	71,77	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	produced|nmod|START_ENTITY produced|nsubj|Attenuation Attenuation|nmod|shock shock|nmod|hypothermia hypothermia|amod|END_ENTITY	Attenuation by electroconvulsive shock and antidepressant drugs of the 5-HT1A receptor-mediated hypothermia and serotonin_syndrome produced by 8-OH-DPAT in the rat .
2967189	0	8-OH-DPAT	152,161	5-HT1A	88,94	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	tetralin|appos|START_ENTITY decreased|dobj|tetralin decreased|nmod|dose dose|nmod|8-hydroxy-2 8-hydroxy-2|nummod|END_ENTITY	Hyperinsulinemia of the genetically obese -LRB- fa/fa -RRB- rat is decreased by a low dose of the 5-HT1A receptor agonist 8-hydroxy-2 - -LRB- di-n-propylamino -RRB- tetralin -LRB- 8-OH-DPAT -RRB- .
2970974	0	8-OH-DPAT	42,51	5-HT1A	67,73	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	response|nmod|START_ENTITY mediated|nsubjpass|response mediated|nmod|receptors receptors|nummod|END_ENTITY	Evidence that the hyperphagic response to 8-OH-DPAT is mediated by 5-HT1A receptors .
2973613	0	8-OH-DPAT	45,54	5-HT1A	28,34	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	agonists|appos|START_ENTITY agonists|amod|END_ENTITY	Specific effect of putative 5-HT1A agonists , 8-OH-DPAT and gepirone , to increase hypertonic_saline_consumption in the rat : evidence against a general hyperdipsic action .
7545820	0	8-OH-DPAT	56,65	5-HT1A	40,46	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	agonist|amod|START_ENTITY agonist|amod|END_ENTITY	Gender and estrous cycle effects of the 5-HT1A agonist , 8-OH-DPAT , on hypothalamic serotonin .
7566483	0	8-OH-DPAT	94,103	5-HT1A	45,51	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	application|nmod|START_ENTITY Stimulation|nmod|application Stimulation|nmod|autoreceptors autoreceptors|nummod|END_ENTITY	Stimulation of median , but not dorsal , raphe 5-HT1A autoreceptors by the local application of 8-OH-DPAT reverses raclopride-induced catalepsy in the rat .
7748502	0	8-OH-DPAT	0,9	5-HT1A	81,87	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	impairs|nummod|START_ENTITY impairs|acl|learning learning|advcl|stimulating stimulating|dobj|receptors receptors|nummod|END_ENTITY	8-OH-DPAT impairs spatial but not visual learning in a water maze by stimulating 5-HT1A receptors in the hippocampus .
7760584	0	8-OH-DPAT	47,56	5-HT1A	22,28	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	attenuate|nsubj|START_ENTITY agonists|ccomp|attenuate agonists|nsubj|Pretreatment Pretreatment|nmod|receptor receptor|nummod|END_ENTITY	Pretreatment with the 5-HT1A receptor agonists 8-OH-DPAT or gepirone does not attenuate the inhibitory effect of systemically administered cholecystokinin -LRB- CCK -RRB- on food intake in rats .
7871012	0	8-OH-DPAT	113,122	5-HT1A	52,58	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	enhances|nmod|START_ENTITY enhances|dobj|induced induced|nummod|END_ENTITY	Chronic lithium treatment enhances the postsynaptic 5-HT1A receptor-mediated 5-HT behavioral syndrome induced by 8-OH-DPAT in rats via catecholaminergic systems .
7984269	0	8-OH-DPAT	48,57	5-HT1A	33,39	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	agonist|nummod|START_ENTITY agonist|nummod|END_ENTITY	The ontogeny of tolerance to the 5-HT1A agonist 8-OH-DPAT : a study in the rat .
7984271	0	8-OH-DPAT	141,150	5-HT1A	125,131	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	agonist|amod|START_ENTITY agonist|amod|END_ENTITY	Repeated cocaine exposure inhibits the adrenocorticotropic hormone response to the serotonin releaser d-fenfluramine and the 5-HT1A agonist , 8-OH-DPAT .
8007747	0	8-OH-DPAT	84,93	5-HT1A	68,74	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	agonists|dobj|START_ENTITY agonists|nsubj|difference difference|nmod|responses responses|nmod|rats rats|nmod|END_ENTITY	Sex difference in the feeding responses of non-deprived rats to the 5-HT1A agonists 8-OH-DPAT and gepirone .
8118681	0	8-OH-DPAT	107,116	5-HT1A	91,97	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	agonist|amod|START_ENTITY agonist|amod|END_ENTITY	Long-term fluoxetine , but not desipramine , inhibits the ACTH and oxytocin responses to the 5-HT1A agonist , 8-OH-DPAT , in male rats .
8208763	0	8-OH-DPAT	107,116	5-HT1A	91,97	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	agonist|amod|START_ENTITY agonist|amod|END_ENTITY	Hypothalamic infusion of the 5-HT2 / 1C agonist , DOI , prevents the inhibitory actions of the 5-HT1A agonist , 8-OH-DPAT , on lordosis_behavior .
8208989	0	8-OH-DPAT	148,157	5-HT1A	91,97	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY response|acl|induced mediated|dobj|response mediated|nsubj|effect effect|nmod|administration administration|nmod|receptor receptor|nummod|END_ENTITY	The effect of chronic administration of antidepressants and electroconvulsive shock on the 5-HT1A receptor mediated hypothermic response induced by 8-OH-DPAT in the rat .
8361577	0	8-OH-DPAT	14,23	5-HT1A	78,84	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	Assessment|nmod|START_ENTITY induced|nsubj|Assessment induced|nmod|model model|nmod|function function|nummod|END_ENTITY	Assessment of 8-OH-DPAT induced spontaneous tailflicks as an in vivo model of 5-HT1A function in young rats .
8431766	0	8-OH-DPAT	79,88	5-HT1A	63,69	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	agonist|amod|START_ENTITY agonist|amod|END_ENTITY	Female sexual behavior following intracerebral infusion of the 5-HT1A agonist , 8-OH-DPAT , into the medial preoptic area .
8472759	0	8-OH-DPAT	70,79	5-HT1A	83,89	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Working memory_deficits induced by intrahippocampal administration of 8-OH-DPAT , a 5-HT1A receptor agonist , in the rat .
8548311	0	8-OH-DPAT	73,82	5-HT1A	58,64	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	agonist|nummod|START_ENTITY agonist|nummod|END_ENTITY	Sleep effects following intrathecal administration of the 5-HT1A agonist 8-OH-DPAT and the NMDA antagonist AP-5 in rats .
8724452	0	8-OH-DPAT	30,39	5-HT1A	14,20	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Effect of the 5-HT1A agonist , 8-OH-DPAT on instrumental performance in rats .
8724453	0	8-OH-DPAT	86,95	5-HT1A	16,22	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY involved|nmod|effects involved|nsubjpass|receptors receptors|amod|END_ENTITY	Somatodendritic 5-HT1A receptors are critically involved in the anxiolytic effects of 8-OH-DPAT .
8741953	0	8-OH-DPAT	64,73	5-HT1A	44,50	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	rhythm|nmod|START_ENTITY rhythm|nmod|response response|nmod|receptors receptors|amod|END_ENTITY	Circadian rhythm in the response of central 5-HT1A receptors to 8-OH-DPAT in rats .
8797023	0	8-OH-DPAT	76,85	5-HT1A	60,66	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	agonist|amod|START_ENTITY agonist|amod|END_ENTITY	Prior treatment with estrogen attenuates the effects of the 5-HT1A agonist , 8-OH-DPAT , on lordosis_behavior .
8820175	0	8-OH-DPAT	54,63	5-HT1A	67,73	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|nmod|receptors receptors|nummod|END_ENTITY	Partial agonistic activity of R - and S-enantiomers of 8-OH-DPAT at 5-HT1A receptors .
9021891	0	8-OH-DPAT	54,63	5-HT1A	92,98	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	administration|nmod|START_ENTITY desensitizes|nsubj|administration desensitizes|dobj|autoreceptors autoreceptors|nummod|END_ENTITY	Chronic administration of the 5-HT1A receptor agonist 8-OH-DPAT differentially desensitizes 5-HT1A autoreceptors of the dorsal and median raphe nuclei .
9079789	0	8-OH-DPAT	91,100	5-HT1A	67,73	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	agonist|dobj|START_ENTITY agonist|nsubj|effects effects|nmod|receptor receptor|nummod|END_ENTITY	Contrasting effects of systemic and intracerebral infusions of the 5-HT1A receptor agonist 8-OH-DPAT on spatial short-term working memory in rats .
9181636	0	8-OH-DPAT	0,9	5-HT1A	13,19	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	8-OH-DPAT , a 5-HT1A agonist and ritanserin , a 5-HT2A / C antagonist , reverse haloperidol-induced catalepsy in rats independently of striatal dopamine release .
9261814	0	8-OH-DPAT	46,55	5-HT1A	26,32	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	receptors|nmod|START_ENTITY receptors|amod|END_ENTITY	Desensitization of spinal 5-HT1A receptors to 8-OH-DPAT : an in vivo spinal reflex study .
9272757	0	8-OH-DPAT	79,88	5-HT1A	189,195	8-OH-DPAT	5-HT1A	MESH:D017371	3350	Chemical	Gene	effects|appos|START_ENTITY blocked|nsubjpass|effects blocked|nmod|antagonist antagonist|amod|END_ENTITY	On the elevated plus-maze the anxiolytic-like effects of the 5-HT -LRB- 1A -RRB- agonist , 8-OH-DPAT , but not the anxiogenic-like effects of the 5-HT -LRB- 1A -RRB- partial agonist , buspirone , are blocked by the 5-HT1A antagonist , WAY_100635 .
9372532	0	8-OH-DPAT	97,106	5-HT1A	82,88	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	agonist|nummod|START_ENTITY agonist|nummod|END_ENTITY	Nicotine withdrawal leads to increased sensitivity of serotonergic neurons to the 5-HT1A agonist 8-OH-DPAT .
9517445	0	8-OH-DPAT	123,132	5-HT1A	17,23	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	that|nmod|START_ENTITY different|nmod|that mechanism|amod|different facilitates|nmod|mechanism facilitates|nsubj|MKC-242 MKC-242|appos|agonist agonist|nummod|END_ENTITY	MKC-242 , a novel 5-HT1A receptor agonist , facilitates cortical acetylcholine release by a mechanism different from that of 8-OH-DPAT in awake rats .
9519243	0	8-OH-DPAT	96,105	5-HT1A	6,12	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	sensitivity|nummod|START_ENTITY bred|nmod|sensitivity bred|nsubj|autoradiography autoradiography|nummod|END_ENTITY	Brain 5-HT1A receptor autoradiography and hypothermic responses in rats bred for differences in 8-OH-DPAT sensitivity .
9650846	0	8-OH-DPAT	85,94	5-HT1A	54,60	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	responses|nummod|START_ENTITY Effects|nmod|responses Effects|dep|Me-8-OH-DPAT Me-8-OH-DPAT|appos|antagonist antagonist|nummod|END_ENTITY	Effects of WAY_100635 and -LRB- - -RRB- -5 - Me-8-OH-DPAT , a novel 5-HT1A receptor antagonist , on 8-OH-DPAT responses .
9694031	0	8-OH-DPAT	25,34	5-HT1A	0,6	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY agonist|nummod|END_ENTITY	5-HT1A receptor agonist -LRB- 8-OH-DPAT -RRB- and 5-HT2 receptor agonist -LRB- DOI -RRB- disrupt the non-cognitive performance of rats in a working memory task .
9862759	0	8-OH-DPAT	145,154	5-HT1A	85,91	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	responses|nmod|START_ENTITY reductions|nmod|responses injections|dep|reductions injections|nmod|desensitization desensitization|nmod|receptors receptors|amod|END_ENTITY	Daily injections of fluoxetine induce dose-dependent desensitization of hypothalamic 5-HT1A receptors : reductions in neuroendocrine responses to 8-OH-DPAT and in levels of Gz and Gi proteins .
9886765	0	8-OH-DPAT	116,125	5-HT1A	80,86	8-OH-DPAT	5-HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	agonists|dobj|START_ENTITY agonists|nsubj|Facilitation Facilitation|nmod|behaviour behaviour|nmod|END_ENTITY	Facilitation and inhibition of male rat ejaculatory behaviour by the respective 5-HT1A and 5-HT1B receptor agonists 8-OH-DPAT and anpirtoline , as evidenced by use of the corresponding new and selective receptor antagonists NAD-299 and NAS-181 .
10412836	0	8-OH-DPAT	90,99	5-HT1A_receptor	66,81	8-OH-DPAT	5-HT1A receptor	MESH:D017371	3350	Chemical	Gene	START_ENTITY|nsubj|Modulation Modulation|nmod|activity activity|nmod|microinjection microinjection|nmod|agonist agonist|amod|END_ENTITY	Modulation of sympathetic nerve activity by microinjection of the 5-HT1A_receptor agonist 8-OH-DPAT into the rostroventrolateral medulla .
17188742	0	8-OH-DPAT	43,52	5-HT1A_receptor	18,33	8-OH-DPAT	5-HT1A receptor	MESH:D017371	3350	Chemical	Gene	agonist|amod|START_ENTITY agonist|amod|END_ENTITY	The effect of the 5-HT1A_receptor agonist , 8-OH-DPAT , on motion-induced emesis in Suncus murinus .
1828770	0	8-OH-DPAT	112,121	5-HT1A_receptor	87,102	8-OH-DPAT	5-HT1A receptor	MESH:D017371	15550(Tax:10090)	Chemical	Gene	agonist|amod|START_ENTITY agonist|amod|END_ENTITY	Is NAN-190 an effective antagonist of the hypothermia and hyperglycemia induced by the 5-HT1A_receptor agonist , 8-OH-DPAT ?
26531424	0	8-OH-DPAT	101,110	5-HT1A_receptor	47,62	8-OH-DPAT	5-HT1A receptor	MESH:D017371	3350	Chemical	Gene	role|nmod|START_ENTITY role|nmod|effects effects|nmod|activation activation|amod|END_ENTITY	The role of genotype in the effects of chronic 5-HT1A_receptor activation with the selective agonist 8-OH-DPAT .
15571670	0	8-OH-DPAT	28,37	5HT1A	4,9	8-OH-DPAT	5HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	agonist|amod|START_ENTITY agonist|nummod|END_ENTITY	The 5HT1A receptor agonist , 8-OH-DPAT , protects neurons and reduces astroglial reaction after ischemic_damage caused by cortical devascularization .
7550544	0	8-OH-DPAT	83,92	5HT1A	69,74	8-OH-DPAT	5HT1A	MESH:D017371	3350	Chemical	Gene	agonist|nummod|START_ENTITY agonist|nummod|END_ENTITY	Attenuation of the fentanyl-induced muscle_rigidity by the selective 5HT1A agonist 8-OH-DPAT .
8082505	1	8-OH-DPAT	100,109	5HT1A	86,91	8-OH-DPAT	5HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	agonist|dobj|START_ENTITY agonist|nsubj|Effect Effect|nmod|END_ENTITY	Effect of selective 5HT1A agonist 8-OH-DPAT .
8657830	0	8-OH-DPAT	53,62	5HT1A	39,44	8-OH-DPAT	5HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	agonist|nummod|START_ENTITY agonist|nummod|END_ENTITY	Discriminative stimulus effects of the 5HT1A agonist 8-OH-DPAT : attenuation by mu but not by kappa opioids .
26792005	0	8-OH-DPAT	82,91	Galanin	0,7	8-OH-DPAT	Galanin	MESH:D017371	29141(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY enhances|dobj|effects enhances|nsubj|END_ENTITY	Galanin -LRB- 1-15 -RRB- enhances the antidepressant effects of the 5-HT1A receptor agonist 8-OH-DPAT : involvement of the raphe-hippocampal 5-HT neuron system .
7904566	0	8-OH-DPAT_ipsapirone	85,105	5-HT1A	60,66	8-OH-DPAT ipsapirone	5-HT1A	null	24473(Tax:10116)	Chemical	Gene	agonists|amod|START_ENTITY agonists|nummod|END_ENTITY	Neuronal circuits involved in the anxiolytic effects of the 5-HT1A receptor agonists 8-OH-DPAT_ipsapirone and buspirone in the rat .
25930741	0	8-OH-modified_adenine	15,36	TLR7	38,42	8-OH-modified adenine	TLR7	null	170743(Tax:10090)	Chemical	Gene	START_ENTITY|appos|ligand ligand|compound|END_ENTITY	Treatment with 8-OH-modified_adenine -LRB- TLR7 ligand -RRB- - allergen conjugates decreases T helper type 2-oriented murine airway inflammation .
7871000	0	8-OHDPAT	147,155	5-HT1A	132,138	8-OHDPAT	5-HT1A	MESH:D017371	15550(Tax:10090)	Chemical	Gene	agonist|nummod|START_ENTITY agonist|nummod|END_ENTITY	Cross-familiarisation conditioned taste aversion procedure as a method to reveal stimulus resemblance between drugs : studies on the 5-HT1A agonist 8-OHDPAT .
20488846	0	8-OHdG	49,55	GSTM1	91,96	8-OHdG	GSTM1	MESH:C040791	2944	Chemical	Gene	concentration|amod|START_ENTITY concentration|nmod|END_ENTITY	Modification of the relationship between urinary 8-OHdG and hippuric_acid concentration by GSTM1 , GSTT1 , and ALDH2 genotypes .
26899729	6	8-OHdG	874,880	mice	1013,1017	8-OHdG	Nrf2	MESH:C067134	18024(Tax:10090)	Chemical	Gene	levels|amod|START_ENTITY END_ENTITY|nsubj|levels	In the short-term study , although 8-hydroxydeoxyguanosine -LRB- 8-OHdG -RRB- levels in the epithelial DNA of Nrf2 -LRB- - / - -RRB- mice at the high dose were significantly lower than those of the corresponding Nrf2 -LRB- + / + -RRB- mice , the difference was very small .
22287164	0	8-Substituted_3-arylcoumarins	0,29	MAO-B	54,59	8-Substituted 3-arylcoumarins	MAO-B	null	4129	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	8-Substituted_3-arylcoumarins as potent and selective MAO-B inhibitors : synthesis , pharmacological evaluation , and docking studies .
25411915	0	8-Tetrahydropyran-2-yl_chromans	0,31	beta-site_amyloid_precursor_protein_cleaving_enzyme_1	50,103	8-Tetrahydropyran-2-yl chromans	beta-site amyloid precursor protein cleaving enzyme 1	null	29392(Tax:10116)	Chemical	Gene	START_ENTITY|dep|inhibitors inhibitors|compound|END_ENTITY	8-Tetrahydropyran-2-yl_chromans : highly selective beta-site_amyloid_precursor_protein_cleaving_enzyme_1 -LRB- BACE1 -RRB- inhibitors .
7990119	0	8-alkyl-N5-deazapterins	65,88	dihydrofolate_reductase	92,115	8-alkyl-N5-deazapterins	dihydrofolate reductase	null	1719	Chemical	Gene	binding|nmod|START_ENTITY binding|acl|END_ENTITY	Structure-activity relationships and pH dependence of binding of 8-alkyl-N5-deazapterins to dihydrofolate_reductase .
24224488	0	8-aminoquinolines	28,45	Methemoglobin	0,13	8-aminoquinolines	Methemoglobin	null	3048	Chemical	Gene	generation|nmod|START_ENTITY generation|compound|END_ENTITY	Methemoglobin generation by 8-aminoquinolines : effect of substitution at 5-position of primaquine .
7273856	0	8-azaguanine	23,35	hypoxanthine_phosphoribosyltransferase	57,95	8-azaguanine	hypoxanthine phosphoribosyltransferase	MESH:D001375	3251	Chemical	Gene	START_ENTITY|nmod|cells cells|nmod|END_ENTITY	Specific resistance to 8-azaguanine in cells with normal hypoxanthine_phosphoribosyltransferase -LRB- HPRT -RRB- activity : the role of guanine_deaminase .
26935885	0	8-bromo-7-methoxychrysin	106,130	STAT3	146,151	8-bromo-7-methoxychrysin	STAT3	MESH:C552860	6774	Chemical	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	Reversal of liver_cancer-associated stellate cell-induced stem-like characteristics in SMMC-7721 cells by 8-bromo-7-methoxychrysin via inhibiting STAT3 activation .
23426174	0	8-c	92,95	ERCC1	42,47	8-c	ERCC1	null	2067	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|expression expression|compound|END_ENTITY	Induction of apoptosis and suppression of ERCC1 expression by the potent amonafide analogue 8-c in human colorectal_carcinoma cells .
9274923	0	8-cyclopentyltheophylline	0,25	adenosine_A1_receptor	30,51	8-cyclopentyltheophylline	adenosine A1 receptor	MESH:C053907	100135472(Tax:10141)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	8-cyclopentyltheophylline , an adenosine_A1_receptor antagonist , inhibits the reversal of long-term potentiation in hippocampal CA1 neurons .
24610348	0	8-dihydroxyflavone	13,31	heme_oxygenase-1	70,86	8-dihydroxyflavone	heme oxygenase-1	null	3162	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Effect of 7 , 8-dihydroxyflavone on the up-regulation of Nrf2-mediated heme_oxygenase-1 expression in hamster lung fibroblasts .
25699405	0	8-fluorotriazolopyridine	34,58	c-Met	59,64	8-fluorotriazolopyridine	c-Met	null	17295(Tax:10090)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Discovery of potent and selective 8-fluorotriazolopyridine c-Met inhibitors .
16610557	0	8-hydoxydeoxyguanosine	8,30	Aldh2	83,88	8-hydoxydeoxyguanosine	Aldh2	null	11669(Tax:10090)	Chemical	Gene	levels|amod|START_ENTITY levels|nmod|END_ENTITY	Urinary 8-hydoxydeoxyguanosine -LRB- 8-OHdG -RRB- and plasma malondialdehyde -LRB- MDA -RRB- levels in Aldh2 knock-out mice under acetaldehyde exposure .
26899729	6	8-hydroxydeoxyguanosine	849,872	mice	1013,1017	8-hydroxydeoxyguanosine	Nrf2	MESH:C067134	18024(Tax:10090)	Chemical	Gene	levels|amod|START_ENTITY END_ENTITY|nsubj|levels	In the short-term study , although 8-hydroxydeoxyguanosine -LRB- 8-OHdG -RRB- levels in the epithelial DNA of Nrf2 -LRB- - / - -RRB- mice at the high dose were significantly lower than those of the corresponding Nrf2 -LRB- + / + -RRB- mice , the difference was very small .
17077538	0	8-hydroxydihydrosanguinarine	34,62	acetylcholinesterase	77,97	8-hydroxydihydrosanguinarine	acetylcholinesterase	MESH:C517196	43	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	8-hydroxydihydrochelerythrine and 8-hydroxydihydrosanguinarine with a potent acetylcholinesterase inhibitory activity from Chelidonium majus L. Ethanol extract of the aerial portion of Chelidonium majus L. inhibited acetylcholinesterase -LRB- AChE -RRB- activity without a significant inhibition of butyrylcholinesterase -LRB- BuChE -RRB- .
14553834	0	8-isoprostane	0,13	interleukin-8	38,51	8-isoprostane	interleukin-8	MESH:C075750	3576	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	8-isoprostane increases expression of interleukin-8 in human macrophages through activation of mitogen-activated protein kinases .
1316170	0	8-methoxycaffeine	0,17	DNA_topoisomerase_II	43,63	8-methoxycaffeine	DNA topoisomerase II	MESH:C066637	35225(Tax:7227)	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	8-methoxycaffeine inhibition of Drosophila DNA_topoisomerase_II .
14633670	0	8-methoxypsoralen	18,35	CYP2A6	52,58	8-methoxypsoralen	CYP2A6	MESH:D008730	1548	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Pretreatment with 8-methoxypsoralen , a potent human CYP2A6 inhibitor , strongly inhibits lung tumorigenesis induced by 4 - -LRB- methylnitrosamino -RRB- -1 - -LRB- 3-pyridyl -RRB- -1 - butanone in female A/J mice .
24475091	0	8-methoxypsoralen	22,39	CYP2A6	100,106	8-methoxypsoralen	CYP2A6	MESH:D008730	1548	Chemical	Gene	variants|amod|START_ENTITY potency|nmod|variants potency|appos|END_ENTITY	Inhibitory potency of 8-methoxypsoralen on cytochrome_P450_2A6 -LRB- CYP2A6 -RRB- allelic variants CYP2A6 15 , CYP2A6 16 , CYP2A6 21 and CYP2A6 22 : differential susceptibility due to different sequence locations of the mutations .
24475091	0	8-methoxypsoralen	22,39	CYP2A6	111,117	8-methoxypsoralen	CYP2A6	MESH:D008730	1548	Chemical	Gene	variants|amod|START_ENTITY potency|nmod|variants potency|appos|21 21|compound|END_ENTITY	Inhibitory potency of 8-methoxypsoralen on cytochrome_P450_2A6 -LRB- CYP2A6 -RRB- allelic variants CYP2A6 15 , CYP2A6 16 , CYP2A6 21 and CYP2A6 22 : differential susceptibility due to different sequence locations of the mutations .
24475091	0	8-methoxypsoralen	22,39	CYP2A6	64,70	8-methoxypsoralen	CYP2A6	MESH:D008730	1548	Chemical	Gene	START_ENTITY|nmod|cytochrome_P450_2A6 cytochrome_P450_2A6|appos|END_ENTITY	Inhibitory potency of 8-methoxypsoralen on cytochrome_P450_2A6 -LRB- CYP2A6 -RRB- allelic variants CYP2A6 15 , CYP2A6 16 , CYP2A6 21 and CYP2A6 22 : differential susceptibility due to different sequence locations of the mutations .
24475091	0	8-methoxypsoralen	22,39	CYP2A6	89,95	8-methoxypsoralen	CYP2A6	MESH:D008730	1548	Chemical	Gene	variants|amod|START_ENTITY variants|nummod|15 15|compound|END_ENTITY	Inhibitory potency of 8-methoxypsoralen on cytochrome_P450_2A6 -LRB- CYP2A6 -RRB- allelic variants CYP2A6 15 , CYP2A6 16 , CYP2A6 21 and CYP2A6 22 : differential susceptibility due to different sequence locations of the mutations .
24215840	0	8-methoxypsoralen	42,59	GILZ	14,18	8-methoxypsoralen	GILZ	MESH:D008730	1831	Chemical	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Activation of GILZ gene by photoactivated 8-methoxypsoralen : potential role of immunoregulatory dendritic cells in extracorporeal photochemotherapy .
2117068	0	8-methoxypsoralen	17,34	cytochrome_P-450	68,84	8-methoxypsoralen	cytochrome P-450	MESH:D008730	13079(Tax:10090)	Chemical	Gene	inactivation|amod|START_ENTITY inactivation|nmod|microsomes microsomes|amod|END_ENTITY	Bioactivation of 8-methoxypsoralen and irreversible inactivation of cytochrome_P-450 in mouse liver microsomes : modification by monoclonal antibodies , inhibition of drug metabolism and distribution of covalent adducts .
2730678	0	8-methoxypsoralen	14,31	cytochrome_P-450	35,51	8-methoxypsoralen	cytochrome P-450	MESH:D008730	25251(Tax:10116)	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of 8-methoxypsoralen by cytochrome_P-450 .
7393988	0	8-monochloro-3-beta-diethylaminoethyl-4-methyl-7-ethoxy_carboxyl_methoxy_coumarin	11,92	AD6	94,97	8-monochloro-3-beta-diethylaminoethyl-4-methyl-7-ethoxy carboxyl methoxy coumarin	AD6	MESH:C025945	64851	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of 8-monochloro-3-beta-diethylaminoethyl-4-methyl-7-ethoxy_carboxyl_methoxy_coumarin -LRB- AD6 -RRB- on aggregation , arachidonic_acid metabolism and thromboxane_B2 formation in human platelets .
25294835	0	8-oxo-dG	51,59	DNA_polymerase_kappa	92,112	8-oxo-dG	DNA polymerase kappa	MESH:C067134	27343	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	The Werner_syndrome_protein limits the error-prone 8-oxo-dG lesion bypass activity of human DNA_polymerase_kappa .
23265901	0	8-oxoadenine	28,40	Toll-like_receptor_7	63,83	8-oxoadenine	Toll-like receptor 7	MESH:C002992	170743(Tax:10090)	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Synthesis and evaluation of 8-oxoadenine derivatives as potent Toll-like_receptor_7 agonists with high water solubility .
21343179	0	8-oxoguanine	62,74	8-oxoguanine-DNA_glycosylase	91,119	8-oxoguanine	8-oxoguanine-DNA glycosylase	MESH:C024829	4968	Chemical	Gene	basis|nmod|START_ENTITY basis|nmod|END_ENTITY	Thermodynamic and kinetic basis for recognition and repair of 8-oxoguanine in DNA by human 8-oxoguanine-DNA_glycosylase .
20667409	0	8-oxoguanine	4,16	hOGG1	32,37	8-oxoguanine	hOGG1	MESH:C024829	4968	Chemical	Gene	I|amod|START_ENTITY I|appos|END_ENTITY	The 8-oxoguanine glycosylase I -LRB- hOGG1 -RRB- Ser326Cys variant affects the susceptibility to multi-vessel_disease in Taiwan coronary_artery_disease patients .
23023196	0	8-ring_polyamides	47,64	COX-2	31,36	8-ring polyamides	COX-2	null	4513	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Promoter scanning of the human COX-2 gene with 8-ring_polyamides : unexpected weakening of polyamide-DNA binding and selectivity by replacing an internal N-Me-pyrrole with b-alanine .
20188695	1	87-amino-acid	186,199	p13	178,181	87-amino-acid	p13	null	440926	Chemical	Gene	protein|amod|START_ENTITY END_ENTITY|appos|protein	Human T_cell_leukemia_virus_type_1 -LRB- HTLV-1 -RRB- encodes p13 , an 87-amino-acid protein that accumulates in the inner mitochondrial membrane .
24918907	0	8CA	34,37	A-FABP	54,60	8CA	A-FABP	null	2167	Chemical	Gene	inhibitors|dep|START_ENTITY inhibitors|nmod|END_ENTITY	Binding modes of three inhibitors 8CA , F8A and I4A to A-FABP studied based on molecular dynamics simulation .
7753334	0	8OHDPAT	32,39	5HT1A	43,48	8OHDPAT	5HT1A	MESH:D017371	24473(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|nummod|END_ENTITY	Differential sites of action of 8OHDPAT , a 5HT1A agonist , on ACTH and PRL secretion in the rat .
20869254	0	9-Dihydroerythromycin_ethers	0,28	motilin	32,39	9-Dihydroerythromycin ethers	motilin	null	4295	Chemical	Gene	agonists|amod|START_ENTITY agonists|amod|END_ENTITY	9-Dihydroerythromycin_ethers as motilin agonists -- developing structure-activity relationships for potency and safety .
26234906	0	9-N-oxamyl_sialosides	39,60	Siglec-7	64,72	9-N-oxamyl sialosides	Siglec-7	null	27036	Chemical	Gene	ligands|amod|START_ENTITY ligands|amod|END_ENTITY	Synthesis and biological evaluation of 9-N-oxamyl_sialosides as Siglec-7 ligands .
23936231	0	9-Phenanthrol	0,13	TRPM4	17,22	9-Phenanthrol	TRPM4	MESH:C091375	171143(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	9-Phenanthrol , a TRPM4 inhibitor , protects isolated rat hearts from ischemia-reperfusion injury .
9128838	0	9-Tetrahydrocannabinol	6,28	proopiomelanocortin	39,58	9-Tetrahydrocannabinol	proopiomelanocortin	null	24664(Tax:10116)	Chemical	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	delta 9-Tetrahydrocannabinol increases proopiomelanocortin gene expression in the arcuate nucleus of the rat hypothalamus .
9188039	0	9-Tetrahydrocannabinol	6,28	tyrosine_hydroxylase	51,71	9-Tetrahydrocannabinol	tyrosine hydroxylase	null	25085(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	delta 9-Tetrahydrocannabinol increases activity of tyrosine_hydroxylase in cultured fetal mesencephalic neurons .
1261569	0	9-alpha-fluorohydrocortisone	115,143	growth_hormone	19,33	9-alpha-fluorohydrocortisone	growth hormone	MESH:D005438	2688	Chemical	Gene	influence|nmod|START_ENTITY END_ENTITY|dep|influence	Repeated circadian growth_hormone , luteinizing hormone , and follicle-stimulating hormone in children : influence of 9-alpha-fluorohydrocortisone .
17603017	0	9-amino-acid	8,20	Sox18	70,75	9-amino-acid	Sox18	null	54345	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	A novel 9-amino-acid transactivation domain in the C-terminal part of Sox18 .
21389257	0	9-benzyl-2-butoxy-8-hydroxy_adenine	16,51	IL-17	61,66	9-benzyl-2-butoxy-8-hydroxy adenine	IL-17	MESH:C559870	16171(Tax:10090)	Chemical	Gene	response|amod|START_ENTITY response|compound|END_ENTITY	The TLR7 ligand 9-benzyl-2-butoxy-8-hydroxy_adenine inhibits IL-17 response by eliciting IL-10 and IL-10-inducing cytokines .
15213310	0	9-beta-D-arabinofuranosyl-2-fluoroadenine	0,41	vascular_endothelial_growth_factor	65,99	9-beta-D-arabinofuranosyl-2-fluoroadenine	vascular endothelial growth factor	MESH:C024352	7422	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	9-beta-D-arabinofuranosyl-2-fluoroadenine inhibits expression of vascular_endothelial_growth_factor through hypoxia-inducible factor-1 in human ovarian_cancer cells .
16574651	0	9-cis-retinoic_acid	0,19	PELP1	75,80	9-cis-retinoic acid	PELP1	MESH:C103303	27043	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	9-cis-retinoic_acid up-regulates expression of transcriptional coregulator PELP1 , a novel coactivator of the retinoid_X_receptor_alpha pathway .
9790997	0	9-cis-retinoic_acid	78,97	THP-1	44,49	9-cis-retinoic acid	THP-1	MESH:C103303	2736	Chemical	Gene	cells|nmod|START_ENTITY cells|compound|END_ENTITY	Induction of PPARgamma1 expression in human THP-1 monocytic_leukemia cells by 9-cis-retinoic_acid is associated with cellular growth suppression .
15650026	0	9-cis-retinoic_acid	0,19	androgen_receptor	29,46	9-cis-retinoic acid	androgen receptor	MESH:C103303	367	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	9-cis-retinoic_acid inhibits androgen_receptor activity through activation of retinoid_X_receptor .
8801865	0	9-cis-retinoic_acid	0,19	apolipoprotein_AI	30,47	9-cis-retinoic acid	apolipoprotein AI	MESH:C103303	335	Chemical	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	9-cis-retinoic_acid increases apolipoprotein_AI secretion and mRNA expression in HepG2 cells .
7786028	0	9-cis-retinoic_acid	0,19	cellular_retinoic_acid_binding_protein-II	46,87	9-cis-retinoic acid	cellular retinoic acid binding protein-II	MESH:C103303	1382	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|gene gene|amod|END_ENTITY	9-cis-retinoic_acid selectively activates the cellular_retinoic_acid_binding_protein-II gene in human neuroblastoma cells .
9518882	0	9-cis-retinoic_acid	51,70	parathyroid_hormone-related_protein	74,109	9-cis-retinoic acid	parathyroid hormone-related protein	MESH:C103303	5744	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Inhibitory effects of 1,25-dihydroxyvitamin _ D3 and 9-cis-retinoic_acid on parathyroid_hormone-related_protein expression by oral_cancer cells -LRB- HSC-3 -RRB- .
15650026	0	9-cis-retinoic_acid	0,19	retinoid_X_receptor	78,97	9-cis-retinoic acid	retinoid X receptor	MESH:C103303	6256	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|activation activation|nmod|END_ENTITY	9-cis-retinoic_acid inhibits androgen_receptor activity through activation of retinoid_X_receptor .
21382444	0	9-cis-retinoids	43,58	CRBPI	22,27	9-cis-retinoids	CRBPI	null	5947	Chemical	Gene	affinities|nmod|START_ENTITY affinities|nmod|END_ENTITY	Binding affinities of CRBPI and CRBPII for 9-cis-retinoids .
7591958	0	9-hydroxyellipticine	45,65	p53	14,17	9-hydroxyellipticine	p53	MESH:C008009	7157	Chemical	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Inhibition of p53 protein phosphorylation by 9-hydroxyellipticine : a possible anticancer mechanism .
9215992	0	9-methoxy-N2-methylellipticinium_acetate	46,86	cytochrome_P-450	109,125	9-methoxy-N2-methylellipticinium acetate	cytochrome P-450	MESH:C091664	25251(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	In vitro neurotoxicity of the antitumor agent 9-methoxy-N2-methylellipticinium_acetate -LRB- MMEA -RRB- : role of brain cytochrome_P-450 .
23704812	0	9-oxononanoic_acid	29,47	phospholipase_A2	56,72	9-oxononanoic acid	phospholipase A2	MESH:C054931	151056	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|activity activity|amod|END_ENTITY	A lipid peroxidation product 9-oxononanoic_acid induces phospholipase_A2 activity and thromboxane_A2 production in human blood .
16403982	0	9-oxononanoyl_cholesterol	66,91	TGFbeta1	28,36	9-oxononanoyl cholesterol	TGFbeta1	MESH:C114702	7040	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression and synthesis of TGFbeta1 is induced in macrophages by 9-oxononanoyl_cholesterol , a major cholesteryl_ester oxidation product .
18297105	0	9-phenanthrol	0,13	TRPM4	29,34	9-phenanthrol	TRPM4	MESH:C091375	54795	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	9-phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels .
24433510	0	9-phenanthrol	28,41	TRPM4	4,9	9-phenanthrol	TRPM4	MESH:C091375	54795	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|channel channel|compound|END_ENTITY	The TRPM4 channel inhibitor 9-phenanthrol .
25323322	0	9-phenanthrol	16,29	TRPM4	0,5	9-phenanthrol	TRPM4	MESH:C091375	171143(Tax:10116)	Chemical	Gene	channels|amod|START_ENTITY channels|nummod|END_ENTITY	TRPM4 inhibitor 9-phenanthrol activates endothelial cell intermediate conductance calcium-activated potassium channels in rat isolated mesenteric artery .
8700141	0	9-tetrahydrocannabinol	72,94	inducible_nitric_oxide_synthase	15,46	9-tetrahydrocannabinol	inducible nitric oxide synthase	null	18126(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Attenuation of inducible_nitric_oxide_synthase gene expression by delta 9-tetrahydrocannabinol is mediated through the inhibition of nuclear factor - kappa B/Rel activation .
6266813	0	9-tetrahydrocannabinol	6,28	prolactin	44,53	9-tetrahydrocannabinol	prolactin	null	24683(Tax:10116)	Chemical	Gene	suppression|amod|START_ENTITY suppression|nmod|secretion secretion|compound|END_ENTITY	Delta 9-tetrahydrocannabinol suppression of prolactin secretion in the rat : lack of direct pituitary effect .
8263818	0	9-tetrahydrocannabinol	6,28	tumor_necrosis_factor-alpha	43,70	9-tetrahydrocannabinol	tumor necrosis factor-alpha	null	21926(Tax:10090)	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Delta 9-tetrahydrocannabinol inhibition of tumor_necrosis_factor-alpha : suppression of post-translational events .
20891010	0	9-tetrahydrocannabinol-11-oic_acid	52,86	15-lipoxygenase	90,105	9-tetrahydrocannabinol-11-oic acid	15-lipoxygenase	null	246	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	/ \ 9-tetrahydrocannabinol and its major metabolite / \ 9-tetrahydrocannabinol-11-oic_acid as 15-lipoxygenase inhibitors .
16763818	0	99mTc	39,44	Pi3-K	13,18	99mTc	Pi3-K	null	5293	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Influence of Pi3-K and PKC activity on 99mTc - -LRB- V -RRB- - DMSA uptake : correlation with tumour_aggressiveness in an in vitro malignant glioblastoma cell line model .
12147542	0	99mTc-RP517	103,114	leukotriene_B4_receptor	122,145	99mTc-RP517	leukotriene B4 receptor	null	1241	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Assessment of myocardial_inflammation produced by experimental coronary_occlusion and reperfusion with 99mTc-RP517 , a new leukotriene_B4_receptor antagonist that preferentially labels neutrophils in vivo .
11160637	0	A-134974	11,19	adenosine_kinase	29,45	A-134974	adenosine kinase	MESH:C422646	25368(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Effects of A-134974 , a novel adenosine_kinase inhibitor , on carrageenan-induced inflammatory hyperalgesia and locomotor activity in rats : evaluation of the sites of action .
11423084	0	A-134974	0,8	adenosine_kinase	18,34	A-134974	adenosine kinase	MESH:C422646	25368(Tax:10116)	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	A-134974 : a novel adenosine_kinase inhibitor , relieves tactile allodynia via spinal sites of action in peripheral nerve injured rats .
1704109	0	A-18-F-amide	47,59	FMRFamide_related_peptides	19,45	A-18-F-amide	FMRFamide related peptides	MESH:C061209	60337(Tax:10116)	Chemical	Gene	effects|dep|START_ENTITY effects|nmod|END_ENTITY	The effects of two FMRFamide_related_peptides -LRB- A-18-F-amide and F-8-F-amide ; ` morphine modulating peptides ' -RRB- on the endocrine and exocrine rat pancreas .
11078406	0	A-192621	11,19	endothelin-1	98,110	A-192621	endothelin-1	MESH:C120508	24323(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|responses responses|nmod|END_ENTITY	Effects of A-192621 .1 , a specific endothelin-B antagonist , on intrarenal hemodynamic responses to endothelin-1 .
9703472	2	A-216546	128,136	ETA	112,115	A-216546	ETA	MESH:C114054	1909	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	Discovery of a potent , 2-nonaryl , highly selective ETA antagonist -LRB- A-216546 -RRB- .
11932067	0	A-286501	43,51	adenosine_kinase	75,91	A-286501	adenosine kinase	MESH:C461484	132	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nsubj|effects	Analgesic and anti-inflammatory effects of A-286501 , a novel orally active adenosine_kinase inhibitor .
12482951	0	A-317491	0,8	P2X3	68,72	A-317491	P2X3	MESH:C470346	81739(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|nmod|receptors receptors|compound|END_ENTITY	A-317491 , a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors , reduces chronic inflammatory and neuropathic_pain in the rat .
15294456	0	A-349821	45,53	histamine_H3_receptor	84,105	A-349821	histamine H3 receptor	MESH:C489829	11255	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Pharmacological and behavioral properties of A-349821 , a selective and potent human histamine_H3_receptor antagonist .
16153699	0	A-412997	0,8	dopamine_D4_receptor	24,44	A-412997	dopamine D4 receptor	MESH:C506999	25432(Tax:10116)	Chemical	Gene	agonist|nsubj|START_ENTITY agonist|amod|END_ENTITY	A-412997 is a selective dopamine_D4_receptor agonist in rats .
19020411	0	A-412997	40,48	dopamine_D4_receptor	10,30	A-412997	dopamine D4 receptor	MESH:C506999	25432(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Selective dopamine_D4_receptor agonist -LRB- A-412997 -RRB- improves cognitive performance and stimulates motor activity without influencing reward-related behaviour in rat .
8119179	0	A-4166	54,60	Ca2	135,138	A-4166	Ca2	MESH:C060142	54231(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|advcl|stimulating stimulating|dobj|influx influx|amod|END_ENTITY	A novel D-phenylalanine-derivative hypoglycemic agent A-4166 increases cytosolic free Ca2 + in rat pancreatic beta-cells by stimulating Ca2 + influx .
8119179	0	A-4166	54,60	Ca2	86,89	A-4166	Ca2	MESH:C060142	54231(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|+ +|amod|END_ENTITY	A novel D-phenylalanine-derivative hypoglycemic agent A-4166 increases cytosolic free Ca2 + in rat pancreatic beta-cells by stimulating Ca2 + influx .
8119179	7	A-4166	1364,1370	Ca2	1345,1348	A-4166	Ca2	MESH:C060142	54231(Tax:10116)	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	The -LSB- Ca2 + -RSB- i response to A-4166 was completely and reversibly inhibited under Ca -LRB- 2 + -RRB- - free conditions as well as by nitrendipine , a blocker of the L-type Ca2 + channel .
9105692	0	A-4166	42,48	Ca2	100,103	A-4166	Ca2	MESH:C060142	54231(Tax:10116)	Chemical	Gene	agent|appos|START_ENTITY agent|acl|increase increase|dobj|END_ENTITY	The ability of a new hypoglycaemic agent , A-4166 , compared to sulphonylureas , to increase cytosolic Ca2 + in pancreatic beta-cells under metabolic inhibition .
15109663	0	A-420983	0,8	lck	47,50	A-420983	lck	MESH:C014175	3932	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	A-420983 : a potent , orally active inhibitor of lck with efficacy in a model of transplant rejection .
16162831	0	A-425619	38,46	TRPV1	60,65	A-425619	TRPV1	MESH:C503120	83810(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Systemic and site-specific effects of A-425619 , a selective TRPV1 receptor antagonist , on wide dynamic range neurons in CFA-treated and uninjured rats .
18755179	0	A-425619	20,28	TRPV1	39,44	A-425619	TRPV1	MESH:C503120	83810(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|receptors receptors|compound|END_ENTITY	Characterization of A-425619 at native TRPV1 receptors : a comparison between dorsal root ganglia and trigeminal ganglia .
22732416	0	A-62176	0,7	epidermal_growth_factor_receptor_2	76,110	A-62176	epidermal growth factor receptor 2	MESH:C091925	2064	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	A-62176 , a potent topoisomerase inhibitor , inhibits the expression of human epidermal_growth_factor_receptor_2 .
3047366	0	A-62198	65,72	renin	48,53	A-62198	renin	MESH:C057156	24715(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Cardiovascular actions of the primate-selective renin inhibitor , A-62198 .
2698944	0	A-64662	22,29	Renin	0,5	A-64662	Renin	MESH:C056622	5972	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Renin inhibition with A-64662 : effect on blood pressure and hormonal response in man .
2179529	0	A-64662	73,80	renin	45,50	A-64662	renin	MESH:C056622	5972	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|responses responses|nmod|inhibition inhibition|compound|END_ENTITY	Renal hemodynamic and excretory responses to renin inhibition induced by A-64662 .
3292414	0	A-64662	31,38	renin	15,20	A-64662	renin	MESH:C056622	24715(Tax:10116)	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|Effects Effects|nmod|END_ENTITY	Effects of the renin inhibitor A-64662 in monkeys and rats with varying baseline plasma renin activity .
3292414	0	A-64662	31,38	renin	88,93	A-64662	renin	MESH:C056622	24715(Tax:10116)	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nmod|activity activity|compound|END_ENTITY	Effects of the renin inhibitor A-64662 in monkeys and rats with varying baseline plasma renin activity .
26966979	0	A-68930	29,36	NLRP3	46,51	A-68930	NLRP3	MESH:C065380	287362(Tax:10116)	Chemical	Gene	Inhibits|nsubj|START_ENTITY Inhibits|dobj|Activation Activation|compound|END_ENTITY	Dopamine D1 Receptor Agonist A-68930 Inhibits NLRP3 Inflammasome Activation , Controls Inflammation , and Alleviates Histopathology in a Rat Model of Spinal_Cord_Injury .
18590784	0	A-705253	28,36	dynamin_1	87,96	A-705253	dynamin 1	MESH:C500488	1759	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	The novel calpain inhibitor A-705253 potently inhibits oligomeric beta-amyloid-induced dynamin_1 and tau cleavage in hippocampal neurons .
1513850	0	A-71623	0,7	CCK-A_receptor	21,35	A-71623	CCK-A receptor	MESH:C066278	12425(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	A-71623 , a selective CCK-A_receptor agonist , suppresses food intake in the mouse , dog , and monkey .
7837233	0	A-71623	132,139	CCK-A_receptor	0,14	A-71623	CCK-A receptor	MESH:C066278	886	Chemical	Gene	Asp-MePhe-NH2|appos|START_ENTITY antagonists|dep|Asp-MePhe-NH2 antagonists|amod|END_ENTITY	CCK-A_receptor selective antagonists derived from the CCK-A_receptor selective tetrapeptide agonist Boc-Trp-Lys -LRB- Tac -RRB- - Asp-MePhe-NH2 -LRB- A-71623 -RRB- .
7837233	0	A-71623	132,139	CCK-A_receptor	54,68	A-71623	CCK-A receptor	MESH:C066278	886	Chemical	Gene	Asp-MePhe-NH2|appos|START_ENTITY antagonists|dep|Asp-MePhe-NH2 antagonists|acl|derived derived|nmod|Boc-Trp-Lys Boc-Trp-Lys|amod|END_ENTITY	CCK-A_receptor selective antagonists derived from the CCK-A_receptor selective tetrapeptide agonist Boc-Trp-Lys -LRB- Tac -RRB- - Asp-MePhe-NH2 -LRB- A-71623 -RRB- .
8343235	0	A-72517	27,34	renin	11,16	A-72517	renin	MESH:C076903	403838(Tax:9615)	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|Effects Effects|nmod|END_ENTITY	Effects of renin inhibitor A-72517 on hemodynamics and cardiac function in sodium-depleted dogs .
8474102	2	A-72517	294,301	renin	118,123	A-72517	renin	MESH:C076903	24715(Tax:10116)	Chemical	Gene	dihydroxy-6-methylheptane|appos|START_ENTITY ,4|dep|dihydroxy-6-methylheptane Development|dep|,4 Development|nmod|efficacious efficacious|appos|inhibitor inhibitor|compound|END_ENTITY	Development of the efficacious , bioavailable renin inhibitor -LRB- 2S -RRB- -2 - benzyl-3 - _ -LSB- -LSB- -LRB- 1-methylpiperazin-4-yl -RRB- sulfonyl -RSB- propionyl -RSB- -3 - thiazol-4-yl-L-alanine_amide of -LRB- 2S ,3 R ,4 S -RRB- -2 - amino-1-cyclohexyl-3 ,4 - dihydroxy-6-methylheptane -LRB- A-72517 -RRB- .
1452292	0	A-74273	59,66	renin	42,47	A-74273	renin	MESH:C078248	403838(Tax:9615)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Discovery of a well-absorbed , efficacious renin inhibitor , A-74273 .
7678671	0	A-74273	25,32	renin	78,83	A-74273	renin	MESH:C078248	403838(Tax:9615)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Effects of high doses of A-74273 , a novel nonpeptidic and orally bioavailable renin inhibitor .
7895605	0	A-74273	34,41	renin	18,23	A-74273	renin	MESH:C078248	403838(Tax:9615)	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|END_ENTITY	The orally active renin inhibitor A-74273 .
26474486	0	A-769662	19,27	IL-6	37,41	A-769662	IL-6	MESH:C512408	16193(Tax:10090)	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	AMPK Activation by A-769662 Controls IL-6 Expression in Inflammatory Arthritis .
16014572	0	A-770041	0,8	Lck	60,63	A-770041	Lck	MESH:C505452	313050(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	A-770041 , a novel and selective small-molecule inhibitor of Lck , prevents heart allograft rejection .
25236161	8	A-770041	1141,1149	Lck	1181,1184	A-770041	Src	MESH:C505452	6714	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|appos|END_ENTITY	A-770041 is a potent Src family kinase -LRB- Lck and Src -RRB- inhibitor .
16216497	0	A-770041	13,21	lck	60,63	A-770041	lck	MESH:C505452	3932	Chemical	Gene	Discovery|nmod|START_ENTITY Discovery|appos|inhibitor inhibitor|compound|END_ENTITY	Discovery of A-770041 , a src-family selective orally active lck inhibitor that prevents organ allograft rejection .
8395248	0	A-78773	0,7	5-lipoxygenase	29,43	A-78773	5-lipoxygenase	MESH:C082739	240	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	A-78773 : a selective , potent 5-lipoxygenase inhibitor .
26515463	0	A-803467	0,8	MDR	84,87	A-803467	MDR	MESH:C520740	18669(Tax:10090)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	A-803467 , a tetrodotoxin-resistant sodium channel blocker , modulates ABCG2-mediated MDR in vitro and in vivo .
16271073	0	A-83-01	20,27	transforming_growth_factor-beta	96,127	A-83-01	transforming growth factor-beta	MESH:C507011	7040	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming_growth_factor-beta .
19464323	0	A-839977	71,79	P2X7_receptor	45,58	A-839977	P2X7 receptor	MESH:C545178	18439(Tax:10090)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	The antihyperalgesic activity of a selective P2X7_receptor antagonist , A-839977 , is lost in IL-1alphabeta knockout mice .
17016515	0	A-841720	112,120	mGluR1	12,18	A-841720	mGluR1	MESH:C516995	14799(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY Blockade|dep|effects Blockade|nmod|results results|amod|END_ENTITY	Blockade of mGluR1 receptor results in analgesia and disruption of motor and cognitive performances : effects of A-841720 , a novel non-competitive mGluR1 receptor antagonist .
17016515	0	A-841720	112,120	mGluR1	146,152	A-841720	mGluR1	MESH:C516995	14799(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Blockade of mGluR1 receptor results in analgesia and disruption of motor and cognitive performances : effects of A-841720 , a novel non-competitive mGluR1 receptor antagonist .
11607045	0	A-86929	82,89	dopamine_D1_receptor	52,72	A-86929	dopamine D1 receptor	MESH:C095427	1812	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Adrogolide HCl -LRB- ABT-431 ; DAS-431 -RRB- , a prodrug of the dopamine_D1_receptor agonist , A-86929 : preclinical pharmacology and clinical data .
8558425	0	A-86929	33,40	dopamine_D1_receptor	65,85	A-86929	dopamine D1 receptor	MESH:C095427	1812	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	ABT-431 : the diacetyl prodrug of A-86929 , a potent and selective dopamine_D1_receptor agonist : in vitro characterization and effects in animal models of Parkinson 's _ disease .
21953601	0	A-889425	18,26	TRPV1	0,5	A-889425	TRPV1	MESH:C540006	83810(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|nummod|END_ENTITY	TRPV1 antagonist , A-889425 , inhibits mechanotransmission in a subclass of rat primary afferent neurons following peripheral inflammation .
23211825	0	A1120	0,5	RBP4	21,25	A1120	RBP4	null	19662(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	A1120 , a nonretinoid RBP4 antagonist , inhibits formation of cytotoxic bisretinoids in the animal model of enhanced retinal lipofuscinogenesis .
11583311	0	A20210	45,51	prothrombin	52,63	A20210	prothrombin	null	2147	Chemical	Gene	mutation|compound|START_ENTITY mutation|compound|END_ENTITY	Phenotypic APC resistance in carriers of the A20210 prothrombin mutation is associated with an increased risk of venous_thrombosis .
6433775	0	A23-187	10,17	TCGF	39,43	A23-187	TCGF	MESH:D000001	16183(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Ionophore A23-187 induces responses to TCGF in mouse lymphocytes .
3934268	0	A23187	22,28	B_cell_activation	56,73	A23187	B cell activation	MESH:D000001	29760	Chemical	Gene	action|nmod|START_ENTITY action|nmod|END_ENTITY	Synergistic action of A23187 and phorbol_ester on human B_cell_activation .
8252915	0	A23187	65,71	Ca2	0,3	A23187	Ca2	MESH:D000001	760	Chemical	Gene	+|nmod|START_ENTITY +|nsubj|END_ENTITY	Ca2 + regulation by cryopreserved bull spermatozoa in response to A23187 .
11223918	0	A23187	18,24	amyloid_precursor_protein	88,113	A23187	amyloid precursor protein	MESH:D000001	54226(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|secretion secretion|nmod|END_ENTITY	Calcium ionophore A23187 specifically decreases the secretion of beta-secretase cleaved amyloid_precursor_protein during apoptosis in primary rat cortical cultures .
3927902	0	A23187	47,53	calmodulin	59,69	A23187	calmodulin	MESH:D000001	808	Chemical	Gene	interactions|nmod|START_ENTITY interactions|nmod|END_ENTITY	Calcium-dependent interactions of an ionophore A23187 with calmodulin .
10423640	0	A23187	109,115	interleukin-2	188,201	A23187	interleukin-2	MESH:D000001	3558	Chemical	Gene	mixture|nmod|START_ENTITY subjects|nmod|mixture subjects|nmod|challenge challenge|nmod|END_ENTITY	Enhancement of natural killer cell activity in HIV-1-infected subjects by a mixture of the calcium ionophore A23187 and the phorbol_ester TPA : lack of response to a similar challenge with interleukin-2 or alpha-interferon .
3122759	0	A23187	118,124	interleukin-2	34,47	A23187	interleukin-2	MESH:D000001	3558	Chemical	Gene	event|nmod|START_ENTITY event|nsubj|modification modification|nmod|END_ENTITY	Posttranslational modification of interleukin-2 is a late event during activation of human T lymphocytes by ionophore A23187 and phorbol_ester .
9207756	0	A23187	56,62	interleukin-2	66,79	A23187	interleukin-2	MESH:D000001	3558	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Effect of phorbol_myristate_acetate -LRB- PMA -RRB- and ionophore A23187 on interleukin-2 levels and proliferation of activated T lymphocytes from patients with lepromatous_leprosy .
8319811	0	A23187	18,24	interleukin-8	33,46	A23187	interleukin-8	MESH:D000001	3576	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Calcium ionophore A23187 induces interleukin-8 gene expression and protein secretion in human monocytic cells .
344858	0	A23187	45,51	mucin	55,60	A23187	mucin	MESH:D000001	423101(Tax:9031)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	The effects of calcium and calcium ionophore A23187 on mucin secretion and potential difference in the isolated chicken trachea -LSB- proceedings -RSB- .
25800874	7	A3B	1492,1495	ZNF384	1470,1476	A3B	ZNF384	null	171017	Chemical	Gene	contributes|xcomp|START_ENTITY contributes|nsubj|END_ENTITY	ZNF384 knockdown reduced the A3B mRNA levels in NIKS expressing E6 , but not in the parental NIKS , indicating that ZNF384 contributes to A3B upregulation by E6 , but not to basal A3B expression .
27074558	0	A674563	35,42	FLT3	53,57	A674563	FLT3	null	2322	Chemical	Gene	Resistance|compound|START_ENTITY Resistance|compound|END_ENTITY	Dual Inhibition of AKT/FLT3-ITD by A674563 Overcomes FLT3 Ligand-Induced Drug Resistance in FLT3-ITD positive AML .
1359571	0	A68552	36,42	CCK	23,26	A68552	CCK	MESH:C078220	12424(Tax:10090)	Chemical	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	Evaluation of a stable CCK agonist -LRB- A68552 -RRB- in conditioned avoidance responding in mice , rats , and primates : comparison with typical and atypical antipsychotics .
2333977	0	A71378	0,6	CCK	10,13	A71378	CCK	MESH:C063897	885	Chemical	Gene	START_ENTITY|dep|agonist agonist|compound|END_ENTITY	A71378 : a CCK agonist with high potency and selectivity for CCK-A receptors .
18593584	0	A769662	0,7	AMP-activated_protein_kinase	30,58	A769662	AMP-activated protein kinase	MESH:C512408	5563	Chemical	Gene	START_ENTITY|appos|activator activator|nmod|END_ENTITY	A769662 , a novel activator of AMP-activated_protein_kinase , inhibits non-proteolytic components of the 26S proteasome by an AMPK-independent mechanism .
10455314	0	A771726	0,7	cyclo-oxygenase-2	81,98	A771726	cyclo-oxygenase-2	MESH:C072876	5743	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	A771726 , the active metabolite of leflunomide , directly inhibits the activity of cyclo-oxygenase-2 in vitro and in vivo in a substrate-sensitive manner .
2111252	0	AA-861	100,106	5-lipoxygenase	74,88	AA-861	5-lipoxygenase	MESH:C036837	240	Chemical	Gene	trial|appos|START_ENTITY trial|nmod|inhibitor inhibitor|amod|END_ENTITY	Randomized double-blind , placebo-controlled clinical trial of a selective 5-lipoxygenase inhibitor -LRB- AA-861 -RRB- for the prevention of seasonal_allergic_rhinitis .
2464711	0	AA-861	10,16	5-lipoxygenase	30,44	AA-861	5-lipoxygenase	MESH:C036837	240	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effect of AA-861 , a selective 5-lipoxygenase inhibitor , on models of allergy in several species .
3000949	0	AA-861	79,85	5-lipoxygenase	89,103	AA-861	5-lipoxygenase	MESH:C036837	25290(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Role of leukotrienes in rat reversed passive Arthus_pleurisy and the effect of AA-861 , a 5-lipoxygenase inhibitor .
3024521	0	AA-861	10,16	5-lipoxygenase	20,34	AA-861	5-lipoxygenase	MESH:C036837	240	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effect of AA-861 , a 5-lipoxygenase inhibitor , on leukotriene synthesis in human polymorphonuclear leukocytes and on cyclooxygenase and 12-lipoxygenase activities in human platelets .
3385768	0	AA-861	26,32	5-lipoxygenase	0,14	AA-861	5-lipoxygenase	MESH:C036837	25290(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	5-lipoxygenase inhibitor -LRB- AA-861 -RRB- attenuates neutrophil-mediated oxidative stress on the venular endothelium in endotoxemia .
6084855	0	AA-861	27,33	5-lipoxygenase	37,51	AA-861	5-lipoxygenase	MESH:C036837	25290(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Pharmacological profile of AA-861 , a 5-lipoxygenase inhibitor .
7690378	0	AA-861	21,27	5-lipoxygenase	29,43	AA-861	5-lipoxygenase	MESH:C036837	25290(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|inhibitor inhibitor|amod|END_ENTITY	Protective effect of AA-861 -LRB- 5-lipoxygenase inhibitor -RRB- on experimental acute_necrotizing_pancreatitis in rats .
1330136	0	AA861	39,44	5-lipoxygenase	13,27	AA861	5-lipoxygenase	MESH:C036837	240	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Effects of a 5-lipoxygenase inhibitor , AA861 , on lipoxygenase metabolism and superoxide anion generation by human polymorphonuclear leukocytes -- potentiation of superoxide anion generation by LTB4 .
2447953	0	AA861	10,15	5-lipoxygenase	19,33	AA861	5-lipoxygenase	MESH:C036837	25290(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effect of AA861 , a 5-lipoxygenase inhibitor , on amylase secretion from rat pancreatic acini .
26105954	0	AB1	47,50	S1P2	30,34	AB1	S1P2	null	9294	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	Antitumor activity of a novel S1P2 antagonist , AB1 , in neuroblastoma .
24561249	0	ABA	23,26	AtWNK9	0,6	ABA	AtWNK9	CHEBI:2365	832881(Tax:3702)	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	AtWNK9 is regulated by ABA and dehydration and is involved in drought tolerance in Arabidopsis .
26176898	0	ABA	57,60	CML37	24,29	ABA	CML37	CHEBI:2365	834244(Tax:3702)	Chemical	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	Calmodulin-like protein CML37 is a positive regulator of ABA during drought stress in Arabidopsis .
26076231	0	ABA	23,26	WRKY33	40,46	ABA	WRKY33	CHEBI:2365	818429(Tax:3702)	Chemical	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Negative regulation of ABA signaling by WRKY33 is critical for Arabidopsis immunity towards Botrytis_cinerea 2100 .
17217461	0	ABA	0,3	miR159	17,23	ABA	miR159	CHEBI:2365	3767694(Tax:3702)	Chemical	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	ABA induction of miR159 controls transcript levels of two MYB factors during Arabidopsis seed germination .
8415868	0	ABBOTT-81282	29,41	angiotensin_II	56,70	ABBOTT-81282	angiotensin II	MESH:C082984	24179(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Antihypertensive activity of ABBOTT-81282 , a nonpeptide angiotensin_II antagonist , in the renal hypertensive rat .
7848624	0	ABBOTT-81988	46,58	angiotensin_II	63,77	ABBOTT-81988	angiotensin II	MESH:C081174	24179(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Cardiovascular effects of orally administered ABBOTT-81988 , an angiotensin_II antagonist , in conscious spontaneously hypertensive rats .
26054751	0	ABC294640	0,9	sphingosine_kinase_2	13,33	ABC294640	sphingosine kinase 2	MESH:C548780	56848	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	ABC294640 , a sphingosine_kinase_2 inhibitor , enhances the antitumor effects of TRAIL in non-small_cell_lung_cancer .
25128791	0	ABT-089	64,71	nicotinic_acetylcholine_receptor	22,54	ABT-089	nicotinic acetylcholine receptor	MESH:C108326	170945(Tax:10116)	Chemical	Gene	agonists|amod|START_ENTITY agonists|compound|END_ENTITY	Administration of the nicotinic_acetylcholine_receptor agonists ABT-089 and ABT-107 attenuates the reinstatement of nicotine-seeking behavior in rats .
23291630	0	ABT-199	0,7	BCL-2	32,37	ABT-199	BCL-2	MESH:C579720	596	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	ABT-199 , a potent and selective BCL-2 inhibitor , achieves antitumor activity while sparing platelets .
23410971	0	ABT-199	0,7	BCL-2	28,33	ABT-199	BCL-2	MESH:C579720	596	Chemical	Gene	START_ENTITY|appos|taking taking|nmod|END_ENTITY	ABT-199 : taking dead aim at BCL-2 .
24346116	0	ABT-199	30,37	BCL-2	10,15	ABT-199	BCL-2	MESH:C579720	596	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Selective BCL-2 inhibition by ABT-199 causes on-target cell death in acute_myeloid_leukemia .
24707940	0	ABT-199	44,51	BCL-2	20,25	ABT-199	BCL-2	MESH:C579720	596	Chemical	Gene	inhibitors|xcomp|START_ENTITY inhibitors|nsubj|activity activity|nmod|family family|compound|END_ENTITY	Ex vivo activity of BCL-2 family inhibitors ABT-199 and ABT-737 combined with 5-azacytidine in myeloid_malignancies .
24994123	0	ABT-199	117,124	BCL-2	67,72	ABT-199	BCL-2	MESH:C579720	596	Chemical	Gene	determines|nmod|START_ENTITY determines|dobj|END_ENTITY	Maturation stage of T-cell_acute_lymphoblastic_leukemia determines BCL-2 versus BCL-XL dependence and sensitivity to ABT-199 .
25301704	0	ABT-199	0,7	BCL-2	31,36	ABT-199	BCL-2	MESH:C579720	596	Chemical	Gene	mediated|nsubj|START_ENTITY mediated|dobj|inhibition inhibition|nmod|END_ENTITY	ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell_acute_lymphoblastic_leukemia .
25882699	6	ABT-199	895,902	BCL2	937,941	ABT-199	MCL1	MESH:C579720	4170	Chemical	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	The BH3 mimetic ABT-199 potently and specifically targets BCL2 .
24402163	0	ABT-199	145,152	Bcl-2	134,139	ABT-199	Bcl-2	MESH:C579720	596	Chemical	Gene	sensitive|nmod|START_ENTITY sensitive|nmod|inhibition inhibition|nmod|END_ENTITY	Both leukaemic and normal peripheral B lymphoid cells are highly sensitive to the selective pharmacological inhibition of prosurvival Bcl-2 with ABT-199 .
25373508	0	ABT-199	0,7	Bcl-2	49,54	ABT-199	Bcl-2	MESH:C579720	596	Chemical	Gene	START_ENTITY|appos|mimetic mimetic|acl:relcl|targets targets|xcomp|END_ENTITY	ABT-199 , a BH3 mimetic that specifically targets Bcl-2 , enhances the antitumor activity of chemotherapy , bortezomib and JQ1 in `` double hit '' lymphoma cells .
25797245	0	ABT-199	106,113	Bcl-2	75,80	ABT-199	Bcl-2	MESH:C579720	596	Chemical	Gene	resistance|compound|START_ENTITY overcome|dobj|resistance END_ENTITY|xcomp|overcome	Biological rational for sequential targeting of Bruton_tyrosine_kinase and Bcl-2 to overcome CD40-induced ABT-199 resistance in mantle_cell_lymphoma .
25590803	0	ABT-199	61,68	MCL-1	0,5	ABT-199	MCL-1	MESH:C579720	4170	Chemical	Gene	resistance|nmod|START_ENTITY resistance|compound|END_ENTITY	MCL-1 and BCL-xL-dependent resistance to the BCL-2 inhibitor ABT-199 can be overcome by preventing PI3K/AKT/mTOR activation in lymphoid_malignancies .
26565405	0	ABT-199	113,120	MCL-1	8,13	ABT-199	MCL-1	MESH:C579720	4170	Chemical	Gene	venetoclax|appos|START_ENTITY sensitizes|nmod|venetoclax sensitizes|nsubj|Loss Loss|nmod|function function|compound|END_ENTITY	Loss in MCL-1 function sensitizes non-Hodgkin 's _ lymphoma cell lines to the BCL-2-selective inhibitor venetoclax -LRB- ABT-199 -RRB- .
26967820	0	ABT-199	113,120	MCL-1	8,13	ABT-199	MCL-1	MESH:C579720	4170	Chemical	Gene	venetoclax|appos|START_ENTITY sensitizes|nmod|venetoclax sensitizes|nsubj|Loss Loss|nmod|function function|compound|END_ENTITY	Loss in MCL-1 function sensitizes non-Hodgkin 's _ lymphoma cell lines to the BCL-2-selective inhibitor venetoclax -LRB- ABT-199 -RRB- .
18451170	0	ABT-263	0,7	Bcl-2	42,47	ABT-263	Bcl-2	MESH:C528561	596	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	ABT-263 : a potent and orally bioavailable Bcl-2 family inhibitor .
18519752	0	ABT-263	39,46	Bcl-2	16,21	ABT-263	Bcl-2	MESH:C528561	596	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|Activity Activity|nmod|family family|compound|END_ENTITY	Activity of the Bcl-2 family inhibitor ABT-263 in a panel of small_cell_lung_cancer xenograft models .
21206976	0	ABT-263	0,7	Bcl-2	11,16	ABT-263	Bcl-2	MESH:C528561	596	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	ABT-263 , a Bcl-2 inhibitor , enhances the susceptibility of lung_adenocarcinoma cells treated with Src inhibitors to anoikis .
21282543	0	ABT-263	29,36	Bcl-2	47,52	ABT-263	Bcl-2	MESH:C528561	596	Chemical	Gene	study|appos|START_ENTITY study|appos|inhibitor inhibitor|compound|END_ENTITY	Phase I study of Navitoclax -LRB- ABT-263 -RRB- , a novel Bcl-2 family inhibitor , in patients with small-cell_lung_cancer and other solid_tumors .
22037880	0	ABT-263	0,7	Bcl-2	79,84	ABT-263	Bcl-2	MESH:C528561	596	Chemical	Gene	sensitizes|nsubj|START_ENTITY sensitizes|advcl|downregulating downregulating|dobj|family family|compound|END_ENTITY	ABT-263 sensitizes TRAIL-resistant hepatocarcinoma cells by downregulating the Bcl-2 family of anti-apoptotic protein .
22538851	0	ABT-263	81,88	Bcl-2	0,5	ABT-263	Bcl-2	MESH:C528561	596	Chemical	Gene	ABT-737|appos|START_ENTITY targets|nmod|ABT-737 targets|advmod|END_ENTITY	Bcl-2 , Bcl-x -LRB- L -RRB- , and Bcl-w are not equivalent targets of ABT-737 and navitoclax -LRB- ABT-263 -RRB- in lymphoid and leukemic cells .
24212376	0	ABT-263	115,122	Bcl-2	71,76	ABT-263	Bcl-2	MESH:C528561	403416(Tax:9615)	Chemical	Gene	navitoclax|appos|START_ENTITY inhibitors|dobj|navitoclax inhibitors|nsubj|role role|nmod|transport transport|nmod|bioavailability bioavailability|nmod|family family|compound|END_ENTITY	The role of lymphatic transport on the systemic bioavailability of the Bcl-2 protein family inhibitors navitoclax -LRB- ABT-263 -RRB- and ABT-199 .
24779770	0	ABT-263	23,30	Bcl-2	4,9	ABT-263	Bcl-2	MESH:C528561	596	Chemical	Gene	increases|nsubj|START_ENTITY END_ENTITY|parataxis|increases	The Bcl-2 / xL inhibitor ABT-263 increases the stability of Mcl-1 mRNA and protein in hepatocellular carcinoma cells .
25047139	0	ABT-263	83,90	Bcl-2	113,118	ABT-263	Bcl-2	MESH:C528561	596	Chemical	Gene	navitoclax|appos|START_ENTITY safety|nmod|navitoclax Effect|appos|safety Effect|appos|inhibitor inhibitor|nmod|END_ENTITY	Effect of rifampin on the pharmacokinetics , safety and tolerability of navitoclax -LRB- ABT-263 -RRB- , a dual inhibitor of Bcl-2 and Bcl-XL , in patients with cancer .
26488112	8	ABT-263	1291,1298	Bcl-2	1266,1271	ABT-263	Bcl-2	MESH:C528561	596	Chemical	Gene	combining|parataxis|START_ENTITY combining|nmod|END_ENTITY	However , by combining SSA with the Bcl-2 / Bcl-xL antagonists ABT-263 or ABT-199 , we were able to overcome this pro-survival effect .
8856845	0	ABT-299	0,7	PAF	17,20	ABT-299	PAF	MESH:C093306	300795(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	ABT-299 , a novel PAF antagonist , attenuates multiple effects of endotoxemia in conscious rats .
10716232	0	ABT-594	45,52	FGF-2	63,68	ABT-594	FGF-2	MESH:C109763	54250(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	The nicotinic_acetylcholine_receptor agonist ABT-594 increases FGF-2 expression in various rat brain regions .
20064548	0	ABT-594	0,7	task	66,70	ABT-594	task	MESH:C109763	29553(Tax:10116)	Chemical	Gene	improves|nsubj|START_ENTITY improves|nmod|END_ENTITY	ABT-594 improves performance in the 5-choice serial reaction time task under conditions of increased difficulty , sub-chronic dosing , and in poorly-performing subjects .
12193125	0	ABT-627	57,64	endothelin_A_receptor	23,44	ABT-627	endothelin A receptor	MESH:C098644	24326(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	Effects of a selective endothelin_A_receptor antagonist , ABT-627 , in healthy normotensive anaesthetized rats developing acute pulmonary_air_embolism .
11082453	0	ABT-702	0,7	adenosine_kinase	115,131	ABT-702	adenosine kinase	MESH:C416933	11534(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	ABT-702 -LRB- 4-amino-5 - -LRB- 3-bromophenyl -RRB- -7 - -LRB- 6-morpholinopyridin-3-yl -RRB- pyrido -LSB- 2 , _ 3-d -RSB- pyrimidine -RRB- , a novel orally effective adenosine_kinase inhibitor with analgesic and anti-inflammatory properties : I .
11264257	0	ABT-702	14,21	adenosine_kinase	31,47	ABT-702	adenosine kinase	MESH:C416933	25368(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	The effect of ABT-702 , a novel adenosine_kinase inhibitor , on the responses of spinal neurones following carrageenan_inflammation and peripheral_nerve_injury .
26066576	0	ABT-702	31,38	adenosine_kinase	3,19	ABT-702	adenosine kinase	MESH:C416933	25368(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	An adenosine_kinase inhibitor , ABT-702 , inhibits spinal nociceptive transmission by adenosine release via equilibrative nucleoside transporters in rat .
18381439	0	ABT-737	24,31	BCL-2	58,63	ABT-737	BCL-2	MESH:C501332	596	Chemical	Gene	efficacy|nmod|START_ENTITY efficacy|appos|inhibitor inhibitor|nmod|END_ENTITY	Therapeutic efficacy of ABT-737 , a selective inhibitor of BCL-2 , in small_cell_lung_cancer .
21761401	0	ABT-737	109,116	BCL-2	92,97	ABT-737	BCL-2	MESH:C501332	596	Chemical	Gene	antagonist|xcomp|START_ENTITY antagonist|nsubj|sensitivity sensitivity|nmod|cells cells|nmod|END_ENTITY	Decreased sensitivity of 17p-deleted chronic_lymphocytic_leukemia cells to a small molecule BCL-2 antagonist ABT-737 .
21772052	0	ABT-737	104,111	BCL-2	17,22	ABT-737	BCL-2	MESH:C501332	596	Chemical	Gene	predicts|nmod|START_ENTITY predicts|nsubj|index index|compound|END_ENTITY	An antiapoptotic BCL-2 family expression index predicts the response of chronic_lymphocytic_leukemia to ABT-737 .
23943652	0	ABT-737	22,29	BCL-2	0,5	ABT-737	BCL-2	MESH:C501332	12043(Tax:10090)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	BCL-2 inhibition with ABT-737 prolongs survival in an NRAS/BCL -2 mouse model of AML by targeting primitive LSK and progenitor cells .
19008458	0	ABT-737	92,99	BCL-XL	28,34	ABT-737	BCL-XL	MESH:C501332	598	Chemical	Gene	induces|nmod|START_ENTITY induces|nsubj|up-regulation up-regulation|nmod|END_ENTITY	Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic_lymphocytic_leukemia .
17200714	0	ABT-737	112,119	BCL2	38,42	ABT-737	BCL2	MESH:C501332	596	Chemical	Gene	sensitivity|nmod|START_ENTITY BIM|appos|sensitivity sequester|dobj|BIM requires|xcomp|sequester requires|dobj|END_ENTITY	Chronic_lymphocytic_leukemia requires BCL2 to sequester prodeath BIM , explaining sensitivity to BCL2 antagonist ABT-737 .
17554384	0	ABT-737	12,19	BCL2	114,118	ABT-737	BCL2	MESH:C501332	596	Chemical	Gene	neutralizes|nsubj|START_ENTITY neutralizes|nmod|treatment treatment|acl|mediated mediated|nmod|expression expression|nmod|END_ENTITY	BH3 mimetic ABT-737 neutralizes resistance to FLT3 inhibitor treatment mediated by FLT3-independent expression of BCL2 in primary AML_blasts .
21514278	0	ABT-737	41,48	BCL2	23,27	ABT-737	BCL2	MESH:C501332	596	Chemical	Gene	inhibitors|amod|START_ENTITY substrates|nsubj|inhibitors B-cell_lymphoma_2|parataxis|substrates B-cell_lymphoma_2|appos|END_ENTITY	The B-cell_lymphoma_2 -LRB- BCL2 -RRB- - inhibitors , ABT-737 and ABT-263 , are substrates for P-glycoprotein .
26172269	0	ABT-737	16,23	BCL2	0,4	ABT-737	BCL2	MESH:C501332	12043(Tax:10090)	Chemical	Gene	Inhibitor|appos|START_ENTITY Inhibitor|compound|END_ENTITY	BCL2 Inhibitor -LRB- ABT-737 -RRB- : A Restorer of Prednisolone Sensitivity in Early T-Cell Precursor-Acute Lymphoblastic_Leukemia with High MEF2C Expression ?
17016430	0	ABT-737	39,46	Bcl-2	8,13	ABT-737	Bcl-2	MESH:C501332	596	Chemical	Gene	Bcl-X|dep|START_ENTITY END_ENTITY|dep|Bcl-X	A novel Bcl-2 / Bcl-X -LRB- L -RRB- / Bcl-w inhibitor ABT-737 as therapy in multiple_myeloma .
17097561	0	ABT-737	16,23	Bcl-2	42,47	ABT-737	Bcl-2	MESH:C501332	12043(Tax:10090)	Chemical	Gene	targets|nsubj|START_ENTITY targets|dobj|proteins proteins|compound|END_ENTITY	The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized .
17283153	0	ABT-737	99,106	Bcl-2	13,18	ABT-737	Bcl-2	MESH:C501332	596	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|members members|compound|END_ENTITY	Influence of Bcl-2 family members on the cellular response of small-cell_lung_cancer cell lines to ABT-737 .
17460700	0	ABT-737	0,7	Bcl-2	25,30	ABT-737	Bcl-2	MESH:C501332	596	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|proteins proteins|compound|END_ENTITY	ABT-737 , an inhibitor of Bcl-2 family proteins , is a potent inducer of apoptosis in multiple_myeloma cells .
17510658	0	ABT-737	97,104	Bcl-2	136,141	ABT-737	Bcl-2	MESH:C501332	596	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|proteins proteins|compound|END_ENTITY	Apoptosis-based dual molecular targeting by INNO-406 , a second-generation Bcr-Abl inhibitor , and ABT-737 , an inhibitor of antiapoptotic Bcl-2 proteins , against Bcr-Abl-positive_leukemia .
18056200	0	ABT-737	34,41	Bcl-2	4,9	ABT-737	Bcl-2	MESH:C501332	596	Chemical	Gene	sensitizes|nsubj|START_ENTITY END_ENTITY|parataxis|sensitizes	The Bcl-2 / Bcl-XL family inhibitor ABT-737 sensitizes ovarian_cancer cells to carboplatin .
18663354	0	ABT-737	48,55	Bcl-2	93,98	ABT-737	Bcl-2	MESH:C501332	596	Chemical	Gene	glioblastomas|nmod|START_ENTITY treatment|nmod|glioblastomas treatment|appos|inhibitor inhibitor|nmod|proteins proteins|compound|END_ENTITY	Apoptosis-based treatment of glioblastomas with ABT-737 , a novel small molecule inhibitor of Bcl-2 family proteins .
19004807	0	ABT-737	41,48	Bcl-2	24,29	ABT-737	Bcl-2	MESH:C501332	12043(Tax:10090)	Chemical	Gene	antagonist|dobj|START_ENTITY antagonist|nsubj|efficacy efficacy|nmod|END_ENTITY	In vivo efficacy of the Bcl-2 antagonist ABT-737 against aggressive Myc-driven_lymphomas .
19088028	0	ABT-737	122,129	Bcl-2	98,103	ABT-737	Bcl-2	MESH:C501332	596	Chemical	Gene	inhibitor|appos|START_ENTITY expressing|dep|inhibitor expressing|nmod|END_ENTITY	Induction of Noxa sensitizes human colorectal_cancer cells expressing Mcl-1 to the small-molecule Bcl-2 / Bcl-xL inhibitor , ABT-737 .
19557638	0	ABT-737	162,169	Bcl-2	137,142	ABT-737	Bcl-2	MESH:C501332	596	Chemical	Gene	Targeting|nsubj|START_ENTITY Targeting|dep|target target|dobj|studies studies|nmod|homology homology|compound|END_ENTITY	Targeting the Bcl-2 family of proteins in Hodgkin_lymphoma : in vitro cytotoxicity , target modulation and drug combination studies of the Bcl-2 homology 3 mimetic ABT-737 .
19557638	0	ABT-737	162,169	Bcl-2	14,19	ABT-737	Bcl-2	MESH:C501332	596	Chemical	Gene	Targeting|nsubj|START_ENTITY Targeting|dobj|family family|compound|END_ENTITY	Targeting the Bcl-2 family of proteins in Hodgkin_lymphoma : in vitro cytotoxicity , target modulation and drug combination studies of the Bcl-2 homology 3 mimetic ABT-737 .
19737541	0	ABT-737	0,7	Bcl-2	18,23	ABT-737	Bcl-2	MESH:C501332	596	Chemical	Gene	overcomes|nsubj|START_ENTITY overcomes|ccomp|mediated mediated|nsubj|END_ENTITY	ABT-737 overcomes Bcl-2 mediated resistance to doxorubicin-DNA adducts .
20038611	0	ABT-737	36,43	Bcl-2	4,9	ABT-737	Bcl-2	MESH:C501332	596	Chemical	Gene	START_ENTITY|amod|homology homology|amod|END_ENTITY	The Bcl-2 homology domain 3 mimetic ABT-737 targets the apoptotic machinery in acute_lymphoblastic_leukemia resulting in synergistic in vitro and in vivo interactions with established drugs .
20307556	0	ABT-737	103,110	Bcl-2	71,76	ABT-737	Bcl-2	MESH:C501332	596	Chemical	Gene	Bcl-w|dobj|START_ENTITY Bcl-w|nsubj|Mitochondrial_fragmentation_and_neuronal_cell_death Mitochondrial_fragmentation_and_neuronal_cell_death|nmod|response response|nmod|END_ENTITY	Mitochondrial_fragmentation_and_neuronal_cell_death in response to the Bcl-2 / Bcl-x -LRB- L -RRB- / Bcl-w antagonist ABT-737 .
21115411	0	ABT-737	58,65	Bcl-2	42,47	ABT-737	Bcl-2	MESH:C501332	596	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|induction induction|nmod|apoptosis apoptosis|nmod|END_ENTITY	Synergistic induction of apoptosis by the Bcl-2 inhibitor ABT-737 and imatinib_mesylate in gastrointestinal_stromal_tumor cells .
21393385	0	ABT-737	42,49	Bcl-2	119,124	ABT-737	Bcl-2	MESH:C501332	596	Chemical	Gene	domain|amod|START_ENTITY reveals|nsubj|domain reveals|dobj|regulation regulation|nmod|bad bad|appos|protein protein|nmod|family family|compound|END_ENTITY	The Bcl-2 homology domain 3 -LRB- BH3 -RRB- mimetic ABT-737 reveals the dynamic regulation of bad , a proapoptotic protein of the Bcl-2 family , by Bcl-xL .
21393385	0	ABT-737	42,49	Bcl-2	4,9	ABT-737	Bcl-2	MESH:C501332	596	Chemical	Gene	domain|amod|START_ENTITY domain|compound|END_ENTITY	The Bcl-2 homology domain 3 -LRB- BH3 -RRB- mimetic ABT-737 reveals the dynamic regulation of bad , a proapoptotic protein of the Bcl-2 family , by Bcl-xL .
21719460	0	ABT-737	42,49	Bcl-2	18,23	ABT-737	Bcl-2	MESH:C501332	12043(Tax:10090)	Chemical	Gene	antagonist|dobj|START_ENTITY antagonist|nsubj|Evaluation Evaluation|nmod|family family|compound|END_ENTITY	Evaluation of the Bcl-2 family antagonist ABT-737 in collagen-induced arthritis .
21955141	0	ABT-737	27,34	Bcl-2	4,9	ABT-737	Bcl-2	MESH:C501332	596	Chemical	Gene	promotes|nsubj|START_ENTITY END_ENTITY|parataxis|promotes	The Bcl-2 / Bcl-XL inhibitor ABT-737 promotes death of retinoblastoma_cancer cells .
22002102	0	ABT-737	125,132	Bcl-2	102,107	ABT-737	Bcl-2	MESH:C501332	596	Chemical	Gene	START_ENTITY|amod|/ /|amod|END_ENTITY	p53-dependent regulation of Mcl-1 contributes to synergistic cell death by ionizing radiation and the Bcl-2 / Bcl-XL inhibitor ABT-737 .
22138435	0	ABT-737	132,139	Bcl-2	10,15	ABT-737	Bcl-2	MESH:C501332	596	Chemical	Gene	lymphoma|nmod|START_ENTITY END_ENTITY|parataxis|lymphoma	Targeting Bcl-2 family proteins in adult_T-cell_leukemia / lymphoma : in vitro and in vivo effects of the novel Bcl-2 family inhibitor ABT-737 .
22214861	0	ABT-737	24,31	Bcl-2	35,40	ABT-737	Bcl-2	MESH:C501332	596	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Therapeutic efficacy of ABT-737 , a Bcl-2 inhibitor , in a canine melanoma cell line .
22538851	0	ABT-737	57,64	Bcl-2	0,5	ABT-737	Bcl-2	MESH:C501332	596	Chemical	Gene	targets|nmod|START_ENTITY targets|advmod|END_ENTITY	Bcl-2 , Bcl-x -LRB- L -RRB- , and Bcl-w are not equivalent targets of ABT-737 and navitoclax -LRB- ABT-263 -RRB- in lymphoid and leukemic cells .
22764103	0	ABT-737	141,148	Bcl-2	51,56	ABT-737	Bcl-2	MESH:C501332	596	Chemical	Gene	defining|nmod|START_ENTITY die|xcomp|defining die|nmod|cells cells|compound|END_ENTITY	Granzyme_B triggers a prolonged pressure to die in Bcl-2 overexpressing cells , defining a window of opportunity for effective treatment with ABT-737 .
23208368	0	ABT-737	32,39	Bcl-2	12,17	ABT-737	Bcl-2	MESH:C501332	12043(Tax:10090)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|END_ENTITY	Synergistic Bcl-2 inhibition by ABT-737 and cyclosporine_A .
23259599	0	ABT-737	0,7	Bcl-2	82,87	ABT-737	Bcl-2	MESH:C501332	596	Chemical	Gene	reverses|nsubj|START_ENTITY reverses|advcl|targeting targeting|dobj|END_ENTITY	ABT-737 reverses the acquired radioresistance of breast_cancer cells by targeting Bcl-2 and Bcl-xL .
23429261	0	ABT-737	117,124	Bcl-2	94,99	ABT-737	Bcl-2	MESH:C501332	596	Chemical	Gene	START_ENTITY|dep|effects effects|nmod|END_ENTITY	pRb/E2F -1 - mediated caspase-dependent induction of Noxa amplifies the apoptotic effects of the Bcl-2 / Bcl-xL inhibitor ABT-737 .
24576507	0	ABT-737	53,60	Bcl-2	30,35	ABT-737	Bcl-2	MESH:C501332	596	Chemical	Gene	resistant|nmod|START_ENTITY resistant|nsubj|cells cells|nmod|levels levels|nmod|END_ENTITY	HCC cells with high levels of Bcl-2 are resistant to ABT-737 via activation of the ROS-JNK-autophagy pathway .
25409124	0	ABT-737	70,77	Bcl-2	53,58	ABT-737	Bcl-2	MESH:C501332	596	Chemical	Gene	Inhibitor|appos|START_ENTITY Inhibitor|compound|END_ENTITY	Ionizing Radiation Sensitizes Breast_Cancer Cells to Bcl-2 Inhibitor , ABT-737 , through Regulating Mcl-1 .
25592064	0	ABT-737	24,31	Bcl-2	64,69	ABT-737	Bcl-2	MESH:C501332	596	Chemical	Gene	treatment|nmod|START_ENTITY induces|nsubj|treatment induces|dobj|apoptosis apoptosis|nmod|cells cells|amod|END_ENTITY	Combined treatment with ABT-737 and VX-680 induces apoptosis in Bcl-2 - and c-FLIP-overexpressing breast_carcinoma cells .
26493374	0	ABT-737	98,105	Bcl-2	0,5	ABT-737	Bcl-2	MESH:C501332	596	Chemical	Gene	cells|nmod|START_ENTITY resistance|nmod|cells confers|dobj|resistance confers|nsubj|phosphorylation phosphorylation|amod|END_ENTITY	Bcl-2 phosphorylation confers resistance of chronic_lymphocytic_leukemia cells to the BH3 mimetic ABT-737 , ABT-263 and ABT-199 by impeding direct binding .
22538851	0	ABT-737	57,64	Bcl-x	7,12	ABT-737	Bcl-x	MESH:C501332	598	Chemical	Gene	targets|nmod|START_ENTITY targets|nsubj|END_ENTITY	Bcl-2 , Bcl-x -LRB- L -RRB- , and Bcl-w are not equivalent targets of ABT-737 and navitoclax -LRB- ABT-263 -RRB- in lymphoid and leukemic cells .
18160428	0	ABT-737	17,24	Bcl-xL	49,55	ABT-737	Bcl-xL	MESH:C501332	598	Chemical	Gene	reveals|nsubj|START_ENTITY reveals|dobj|role role|nmod|END_ENTITY	Bcl-xL inhibitor ABT-737 reveals a dual role for Bcl-xL in synaptic transmission .
19088028	0	ABT-737	122,129	Bcl-xL	104,110	ABT-737	Bcl-xL	MESH:C501332	598	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Induction of Noxa sensitizes human colorectal_cancer cells expressing Mcl-1 to the small-molecule Bcl-2 / Bcl-xL inhibitor , ABT-737 .
20799354	0	ABT-737	22,29	Bcl-xL	4,10	ABT-737	Bcl-xL	MESH:C501332	598	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	The Bcl-xL inhibitor , ABT-737 , efficiently induces apoptosis and suppresses growth of hepatoma cells in combination with sorafenib .
21393385	0	ABT-737	42,49	Bcl-xL	136,142	ABT-737	Bcl-xL	MESH:C501332	598	Chemical	Gene	domain|amod|START_ENTITY reveals|nsubj|domain reveals|nmod|END_ENTITY	The Bcl-2 homology domain 3 -LRB- BH3 -RRB- mimetic ABT-737 reveals the dynamic regulation of bad , a proapoptotic protein of the Bcl-2 family , by Bcl-xL .
24058878	0	ABT-737	0,7	Bcl-xL	32,38	ABT-737	Bcl-xL	MESH:C501332	598	Chemical	Gene	START_ENTITY|appos|Bcl-2 Bcl-2|dep|antagonist antagonist|dep|END_ENTITY	ABT-737 , a small molecule Bcl-2 / Bcl-xL antagonist , increases antimitotic-mediated apoptosis in human prostate_cancer cells .
20160166	0	ABT-737	88,95	JAK2	99,103	ABT-737	JAK2	MESH:C501332	3717	Chemical	Gene	START_ENTITY|nmod|cells cells|nummod|END_ENTITY	Apoptosis induced by JAK2 inhibition is mediated by Bim and enhanced by the BH3 mimetic ABT-737 in JAK2 mutant human erythroid cells .
23285061	0	ABT-737	0,7	JNK	35,38	ABT-737	JNK	MESH:C501332	5599	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	ABT-737 induces Bim expression via JNK signaling pathway and its effect on the radiation sensitivity of HeLa cells .
24525728	0	ABT-737	69,76	MCL-1	46,51	ABT-737	MCL-1	MESH:C501332	4170	Chemical	Gene	sensitivity|compound|START_ENTITY sensitivity|compound|END_ENTITY	Noxa determines localization and stability of MCL-1 and consequently ABT-737 sensitivity in small_cell_lung_cancer .
21225911	0	ABT-737	63,70	MLL	119,122	ABT-737	MLL	MESH:C501332	4297	Chemical	Gene	START_ENTITY|nmod|cells cells|nmod|END_ENTITY	Cytotoxicity , drug combinability , and biological correlates of ABT-737 against acute_lymphoblastic_leukemia cells with MLL rearrangement .
23344663	0	ABT-737	56,63	Noxa	91,95	ABT-737	Noxa	MESH:C501332	5366	Chemical	Gene	START_ENTITY|nmod|modulation modulation|nmod|END_ENTITY	Platinum compounds sensitize ovarian_carcinoma cells to ABT-737 by modulation of the Mcl-1 / Noxa axis .
18599488	0	ABT-737	0,7	death_receptor_5	34,50	ABT-737	death receptor 5	MESH:C501332	8795	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	ABT-737 induces expression of the death_receptor_5 and sensitizes human cancer cells to TRAIL-induced apoptosis .
7490726	0	ABT-761	89,96	5-lipoxygenase	119,133	ABT-761	5-lipoxygenase	MESH:C096921	240	Chemical	Gene	N-hydroxyurea|appos|START_ENTITY N-hydroxyurea|appos|inhibitor inhibitor|amod|END_ENTITY	-LRB- R -RRB- - -LRB- + -RRB- - N - -LSB- 3 - -LSB- 5 - -LSB- -LRB- 4-fluorophenyl -RRB- methyl -RSB- -2 - thienyl -RSB- -1 - methyl - _ 2-propynyl -RSB- - N-hydroxyurea -LRB- ABT-761 -RRB- , a second-generation 5-lipoxygenase inhibitor .
9117020	0	ABT-761	14,21	5-lipoxygenase	31,45	ABT-761	5-lipoxygenase	MESH:C096921	240	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	The effect of ABT-761 , a novel 5-lipoxygenase inhibitor , on exercise - and adenosine-induced bronchoconstriction in asthmatic subjects .
9542476	0	ABT-761	109,116	5-lipoxygenase	83,97	ABT-761	5-lipoxygenase	MESH:C096921	240	Chemical	Gene	Pharmacokinetics|appos|START_ENTITY Pharmacokinetics|nmod|doses doses|nmod|inhibitor inhibitor|amod|END_ENTITY	Pharmacokinetics and pharmacodynamics of single and multiple oral doses of a novel 5-lipoxygenase inhibitor -LRB- ABT-761 -RRB- in healthy volunteers .
9569998	0	ABT-761	70,77	5-lipoxygenase	44,58	ABT-761	5-lipoxygenase	MESH:C096921	240	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Dose-proportional pharmacokinetics of a new 5-lipoxygenase inhibitor , ABT-761 , in healthy volunteers .
9596112	0	ABT-761	39,46	5-lipoxygenase	13,27	ABT-761	5-lipoxygenase	MESH:C096921	240	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Effects of a 5-lipoxygenase inhibitor , ABT-761 , on exercise-induced bronchoconstriction and urinary LTE4 in asthmatic patients .
9702850	0	ABT-761	11,18	5-lipoxygenase	28,42	ABT-761	5-lipoxygenase	MESH:C096921	240	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effects of ABT-761 , a novel 5-lipoxygenase inhibitor , on the pharmacokinetics of a single dose of ethinyl_estradiol and levonorgestrel in healthy female volunteers .
9923573	0	ABT-761	54,61	5-lipoxygenase	28,42	ABT-761	5-lipoxygenase	MESH:C096921	240	Chemical	Gene	Pharmacokinetics|appos|START_ENTITY Pharmacokinetics|nmod|inhibitor inhibitor|amod|END_ENTITY	Pharmacokinetics of a novel 5-lipoxygenase inhibitor -LRB- ABT-761 -RRB- in pediatric patients with asthma .
10099073	0	ABT-761	50,57	cytochrome_P450_1A2	8,27	ABT-761	cytochrome P450 1A2	MESH:C096921	1544	Chemical	Gene	effect|nmod|START_ENTITY effect|amod|END_ENTITY	Lack of cytochrome_P450_1A2 interaction effect of ABT-761 on the pharmacokinetics of theophylline .
17209055	0	ABT-869	0,7	FLT3	75,79	ABT-869	FLT3	MESH:C513486	2322	Chemical	Gene	START_ENTITY|dep|inhibition inhibition|nmod|END_ENTITY	ABT-869 , a multitargeted receptor tyrosine kinase inhibitor : inhibition of FLT3 phosphorylation and signaling in acute_myeloid_leukemia .
21719137	0	ABT-888	42,49	EGFR	84,88	ABT-888	EGFR	MESH:C521013	1956	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	The poly -LRB- ADP-Ribose -RRB- _ polymerase inhibitor ABT-888 reduces radiation-induced nuclear EGFR and augments head_and_neck_tumor response to radiotherapy .
21795476	0	ABT-888	32,39	PARP	17,21	ABT-888	PARP	MESH:C521013	1302	Chemical	Gene	START_ENTITY|nsubj|study study|nmod|inhibitor inhibitor|compound|END_ENTITY	Phase I study of PARP inhibitor ABT-888 in combination with topotecan in adults with refractory solid tumors and lymphomas .
23571810	0	ABT-925	80,87	dopamine_D3_receptor	48,68	ABT-925	dopamine D3 receptor	null	1814	Chemical	Gene	response|compound|START_ENTITY response|amod|END_ENTITY	Association of dopamine-related genetic loci to dopamine_D3_receptor antagonist ABT-925 clinical response .
27056887	0	ABT199	37,43	BCL-2	21,26	ABT199	BCL-2	MESH:C579720	596	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|efficacy efficacy|nmod|END_ENTITY	High efficacy of the BCL-2 inhibitor ABT199 -LRB- venetoclax -RRB- in BCL-2 high-expressing neuroblastoma cell lines and xenografts and rational for combination with MCL-1 inhibition .
26671995	0	ABTL0812	23,31	Tribbles-3_Pseudokinase	77,100	ABTL0812	Tribbles-3 Pseudokinase	null	57761	Chemical	Gene	Inhibits|nsubj|START_ENTITY Inhibits|nmod|END_ENTITY	The New Antitumor Drug ABTL0812 Inhibits the Akt/mTORC1 Axis by Upregulating Tribbles-3_Pseudokinase .
26833899	0	AC-264613	41,50	protease-activated_receptor_2	2,31	AC-264613	protease-activated receptor 2	null	2150	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	A protease-activated_receptor_2 agonist -LRB- AC-264613 -RRB- suppresses interferon_regulatory_factor_5 and decreases interleukin-12p40 production by lipopolysaccharide-stimulated macrophages : Role of p53 .
7587855	0	AC137	89,94	amylin	104,110	AC137	amylin	MESH:C105254	3375	Chemical	Gene	START_ENTITY|appos|analogue analogue|compound|END_ENTITY	Reduction of postprandial hyperglycemia in subjects with IDDM by intravenous infusion of AC137 , a human amylin analogue .
19654408	0	AC220	0,5	FLT3	54,58	AC220	FLT3	null	2322	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute_myeloid_leukemia -LRB- AML -RRB- .
10502409	0	ACA	86,89	Nhp2	59,63	ACA	Nhp2	null	851319(Tax:4932)	Chemical	Gene	component|nmod|START_ENTITY component|amod|END_ENTITY	Functional conservation and cell cycle localization of the Nhp2 core component of H + ACA snoRNPs in fission and budding yeasts .
16649551	0	ACEA	0,4	CB1	65,68	ACEA	CB1	null	25248(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	ACEA -LRB- arachidonyl-2-chloroethylamide -RRB- , the selective cannabinoid CB1 receptor agonist , protects against aspirin-induced gastric_ulceration .
19827302	0	ACEA	62,66	CB1	92,95	ACEA	CB1	null	25248(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Involvement of nitric_oxide in the gastroprotective effect of ACEA , a selective cannabinoid CB1 receptor agonist , on aspirin-induced gastric_ulceration .
1682427	0	ACNU	54,58	L-asparaginase	73,87	ACNU	L-asparaginase	MESH:D015376	246307(Tax:10116)	Chemical	Gene	resistance|amod|START_ENTITY resistance|nmod|END_ENTITY	Hypersensitivity_of_rat_glioma sublines with acquired ACNU resistance to L-asparaginase .
26604012	0	ACY-738	29,36	HDAC6	9,14	ACY-738	HDAC6	MESH:C583720	15185(Tax:10090)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Specific HDAC6 inhibition by ACY-738 reduces SLE pathogenesis in NZB/W mice .
16248990	0	ACh	74,77	AChE	98,102	ACh	AChE	CHEBI:22614	83817(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY increase|dobj|release increase|advcl|blocking blocking|dobj|activity activity|amod|END_ENTITY	Nicotinic-receptor potentiator drugs , huprine_X and galantamine , increase ACh release by blocking AChE activity but not acting on nicotinic receptors .
23931437	2	ACh	317,320	AChE	370,374	ACh	AChE	CHEBI:22614	43	Chemical	Gene	acetylcholine|appos|START_ENTITY level|nmod|acetylcholine restoration|nmod|level restoration|nmod|inhibition inhibition|nmod|acetylcholinesterase acetylcholinesterase|appos|END_ENTITY	One possible approach for the treatment of this disease is the restoration of the level of acetylcholine -LRB- ACh -RRB- through the inhibition of acetylcholinesterase -LRB- AChE -RRB- with reversible inhibitors .
25096900	0	ACh	173,176	AChE	146,150	ACh	AChE	CHEBI:22614	43	Chemical	Gene	Activity|nmod|START_ENTITY Activity|nmod|END_ENTITY	In Vitro Effect of H2O_2 , Some Transition Metals and Hydroxyl Radical Produced Via Fenton and Fenton-Like Reactions , on the Catalytic Activity of AChE and the Hydrolysis of ACh .
25362152	0	ACh	38,41	CA1	65,68	ACh	CA1	CHEBI:22614	12346(Tax:10090)	Chemical	Gene	release|compound|START_ENTITY release|nmod|END_ENTITY	Activation of muscarinic receptors by ACh release in hippocampal CA1 depolarizes VIP but has varying effects on parvalbumin-expressing basket cells .
25556796	0	ACh	38,41	CA1	65,68	ACh	CA1	CHEBI:22614	12346(Tax:10090)	Chemical	Gene	release|compound|START_ENTITY release|nmod|END_ENTITY	Activation of muscarinic receptors by ACh release in hippocampal CA1 depolarizes VIP but has varying effects on parvalbumin-expressing basket cells .
1810458	0	ACh	26,29	alpha-subunit	39,52	ACh	alpha-subunit	CHEBI:22614	395381(Tax:9031)	Chemical	Gene	mRNA|compound|START_ENTITY mRNA|amod|END_ENTITY	Kinetics of expression of ACh receptor alpha-subunit mRNA in denervated and stimulated muscle .
14757515	0	ACh	42,45	alpha9	35,41	ACh	alpha9	CHEBI:22614	104099(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Mouse outer hair cells lacking the alpha9 ACh receptor are motile .
24820623	0	ACh	17,20	milk	33,37	ACh	milk	CHEBI:22614	100532204	Chemical	Gene	Analysis|nmod|START_ENTITY Analysis|nmod|END_ENTITY	Analysis of free ACh and 5-HT in milk from four different species and their bioactivity on 5-HT -LRB- 3 -RRB- and nACh receptors .
19403649	0	ADP	17,20	CD38	37,41	ADP	CD38	MESH:D000244	12494(Tax:10090)	Chemical	Gene	exhibit|compound|START_ENTITY exhibit|compound|END_ENTITY	Mice lacking the ADP ribosyl cyclase CD38 exhibit attenuated renal vasoconstriction to angiotensin_II , endothelin-1 , and norepinephrine .
14577157	0	ADP	11,14	GroEL	64,69	ADP	GroEL	MESH:D000244	3329	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of ADP and GroES on interaction of molecular chaperonin GroEL with non-native lysozyme -RSB- .
20926656	0	ADP	16,19	Histone_H1	0,10	ADP	Histone H1	MESH:D000244	50708(Tax:10090)	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	Histone_H1 poly -LSB- ADP -RSB- - ribosylation regulates the chromatin alterations required for learning consolidation .
22250198	0	ADP	46,49	P2X7	77,81	ADP	P2X7	MESH:D000244	5027	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Adenylate_cyclase_5 coordinates the action of ADP , P2Y1 , P2Y13 and ATP-gated P2X7 receptors on axonal elongation .
15514209	0	ADP	102,105	P2Y1	18,22	ADP	P2Y1	MESH:D000244	5028	Chemical	Gene	response|nmod|START_ENTITY associated|nmod|response associated|nsubjpass|Dimorphism Dimorphism|nmod|gene gene|compound|END_ENTITY	Dimorphism in the P2Y1 ADP receptor gene is associated with increased platelet activation response to ADP .
15514209	0	ADP	23,26	P2Y1	18,22	ADP	P2Y1	MESH:D000244	5028	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Dimorphism in the P2Y1 ADP receptor gene is associated with increased platelet activation response to ADP .
16934758	0	ADP	50,53	P2Y1	65,69	ADP	P2Y1	MESH:D000244	5028	Chemical	Gene	activating|nsubj|START_ENTITY activating|dobj|receptors receptors|compound|END_ENTITY	Regulation of death and survival in astrocytes by ADP activating P2Y1 and P2Y12 receptors .
18174464	0	ADP	0,3	P2Y1	52,56	ADP	P2Y1	MESH:D000244	5028	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|migration migration|nmod|pathways pathways|nummod|END_ENTITY	ADP stimulates human endothelial cell migration via P2Y1 nucleotide receptor-mediated mitogen-activated protein kinase pathways .
12814667	0	ADP	124,127	P2Y12	33,38	ADP	P2Y12	MESH:D000244	64803(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY reveal|dobj|receptors reveal|nsubj|antagonists antagonists|compound|END_ENTITY	2-Alkylthio-substituted platelet P2Y12 receptor antagonists reveal pharmacological identity between the rat brain Gi-linked ADP receptors and P2Y12 .
15199474	0	ADP	22,25	P2Y12	0,5	ADP	P2Y12	MESH:D000244	64805	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|appos|receptor	P2Y12 , a new platelet ADP receptor , target of clopidogrel .
15345752	0	ADP	161,164	P2Y12	100,105	ADP	P2Y12	MESH:D000244	64805	Chemical	Gene	analog|compound|START_ENTITY constraint|nmod|analog agonist|nmod|constraint agonist|nmod|P2Y1_receptor P2Y1_receptor|nmod|END_ENTITY	Induction of novel agonist selectivity for the ADP-activated P2Y1_receptor versus the ADP-activated P2Y12 and P2Y13 receptors by conformational constraint of an ADP analog .
15886804	0	ADP	6,9	P2Y12	0,5	ADP	P2Y12	MESH:D000244	64805	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	P2Y12 ADP receptor-dependent tyrosine phosphorylation of proteins of 27 and 31 kDa in thrombin-stimulated human platelets .
16706985	0	ADP	17,20	P2Y12	38,43	ADP	P2Y12	MESH:D000244	64805	Chemical	Gene	interaction|compound|START_ENTITY interaction|nmod|receptor receptor|nummod|END_ENTITY	Critical role of ADP interaction with P2Y12 receptor in the maintenance of alpha -LRB- IIb -RRB- beta3 activation : association with Rap1B activation .
20952684	0	ADP	82,85	P2Y12	12,17	ADP	P2Y12	MESH:D000244	70839(Tax:10090)	Chemical	Gene	function|nmod|START_ENTITY function|nsubj|Role Role|nmod|receptor receptor|compound|END_ENTITY	Role of the P2Y12 receptor in the modulation of murine dendritic cell function by ADP .
26391841	0	ADP	54,57	P2Y12	73,78	ADP	P2Y12	MESH:D000244	64805	Chemical	Gene	signaling|nmod|START_ENTITY signaling|advcl|acting acting|nmod|receptor receptor|compound|END_ENTITY	Modulation and pre-amplification of PAR1 signaling by ADP acting via the P2Y12 receptor during platelet subpopulation formation .
15604418	0	ADP	0,3	P2Y13	14,19	ADP	P2Y13	MESH:D000244	53829	Chemical	Gene	START_ENTITY|acl|acting acting|nmod|receptors receptors|nummod|END_ENTITY	ADP acting on P2Y13 receptors is a negative feedback pathway for ATP release from human red blood cells .
7501027	0	ADP	51,54	brush_border_myosin_I	26,47	ADP	brush border myosin I	MESH:D000244	4640	Chemical	Gene	release|compound|START_ENTITY END_ENTITY|nmod|release	A 32 degree tail swing in brush_border_myosin_I on ADP release .
7272509	0	ADP	0,3	fibrinogen	48,58	ADP	fibrinogen	MESH:D000244	2244	Chemical	Gene	release|compound|START_ENTITY release|nmod|END_ENTITY	ADP and epinephrine-induced release of platelet fibrinogen .
2015827	0	ADP2	13,17	phosphoglycerate_kinase	48,71	ADP2	phosphoglycerate kinase	MESH:C054552	850370(Tax:4932)	Chemical	Gene	roles|nmod|START_ENTITY roles|nmod|END_ENTITY	The roles of ADP2 - and Mg2 + in control steps of phosphoglycerate_kinase .
16740780	0	ADW742	60,66	Insulin-like_growth_factor_I_receptor	0,37	ADW742	Insulin-like growth factor I receptor	MESH:C531185	3480	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Insulin-like_growth_factor_I_receptor pathway inhibition by ADW742 , alone or in combination with imatinib , doxorubicin , or vincristine , is a novel therapeutic approach in Ewing_tumor .
22392572	0	AEE788	17,23	ErbB	58,62	AEE788	ErbB	MESH:C489254	1956	Chemical	Gene	study|nmod|START_ENTITY study|appos|inhibitor inhibitor|nmod|END_ENTITY	Phase I study of AEE788 , a novel multitarget inhibitor of ErbB - and VEGF-receptor-family tyrosine_kinases , in recurrent glioblastoma patients .
20380868	0	AEE788	0,6	vascular_endothelial_growth_factor	12,46	AEE788	vascular endothelial growth factor	MESH:C489254	7422	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|compound|END_ENTITY	AEE788 is a vascular_endothelial_growth_factor receptor tyrosine kinase inhibitor with antiproliferative and proapoptotic effects in acute_myeloid_leukemia .
20828803	0	AEZS-108	45,53	LHRH	67,71	AEZS-108	LHRH	MESH:C080883	2796	Chemical	Gene	escalation|nmod|START_ENTITY escalation|appos|agonist agonist|compound|END_ENTITY	Dose escalation and pharmacokinetic study of AEZS-108 -LRB- AN-152 -RRB- , an LHRH agonist linked to doxorubicin , in women with LHRH_receptor-positive_tumors .
21667032	0	AEZS-108	38,46	LHRH	60,64	AEZS-108	LHRH	MESH:C080883	2796	Chemical	Gene	START_ENTITY|nmod|pancreatic_cancers pancreatic_cancers|amod|END_ENTITY	Effective targeted chemotherapy using AEZS-108 -LRB- AN-152 -RRB- for LHRH receptor-positive pancreatic_cancers .
22577891	0	AEZS-108	0,8	LHRH	42,46	AEZS-108	LHRH	MESH:C080883	2796	Chemical	Gene	START_ENTITY|dep|analog analog|nmod|END_ENTITY	AEZS-108 : a targeted cytotoxic analog of LHRH for the treatment of cancers positive for LHRH receptors .
22577891	0	AEZS-108	0,8	LHRH	89,93	AEZS-108	LHRH	MESH:C080883	2796	Chemical	Gene	START_ENTITY|dep|analog analog|nmod|LHRH LHRH|nmod|treatment treatment|nmod|cancers cancers|amod|positive positive|nmod|receptors receptors|compound|END_ENTITY	AEZS-108 : a targeted cytotoxic analog of LHRH for the treatment of cancers positive for LHRH receptors .
24418927	0	AEZS-108	23,31	LHRH	135,139	AEZS-108	LHRH	MESH:C080883	2796	Chemical	Gene	START_ENTITY|acl|expressing expressing|dobj|receptors receptors|compound|END_ENTITY	Efficacy and safety of AEZS-108 -LRB- LHRH agonist linked to doxorubicin -RRB- in women with advanced or recurrent endometrial_cancer expressing LHRH receptors : a multicenter phase 2 trial -LRB- AGO-GYN5 -RRB- .
24418927	0	AEZS-108	23,31	LHRH	33,37	AEZS-108	LHRH	MESH:C080883	2796	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Efficacy and safety of AEZS-108 -LRB- LHRH agonist linked to doxorubicin -RRB- in women with advanced or recurrent endometrial_cancer expressing LHRH receptors : a multicenter phase 2 trial -LRB- AGO-GYN5 -RRB- .
24994120	0	AEZS-108	75,83	LHRH	68,72	AEZS-108	LHRH	MESH:C080883	2796	Chemical	Gene	analog|appos|START_ENTITY analog|nmod|luteinizing_hormone-releasing_hormone luteinizing_hormone-releasing_hormone|appos|END_ENTITY	Targeted cytotoxic analog of luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- , AEZS-108 -LRB- AN-152 -RRB- , inhibits the growth of DU-145 human castration-resistant prostate_cancer in vivo and in vitro through elevating p21 and ROS levels .
25467586	0	AF-219	26,32	P2X3	0,4	AF-219	P2X3	null	5024	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	P2X3 receptor antagonist -LRB- AF-219 -RRB- in refractory chronic cough : a randomised , double-blind , placebo-controlled phase 2 study .
25467586	0	AF-219	26,32	P2X3	0,4	AF-219	P2X3	null	5024	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	P2X3 receptor antagonist -LRB- AF-219 -RRB- in refractory chronic cough : a randomised , double-blind , placebo-controlled phase 2 study .
11117548	0	AF102B	36,42	Abeta	69,74	AF102B	Abeta	MESH:C059240	351	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|levels levels|nmod|END_ENTITY	The selective muscarinic M1 agonist AF102B decreases levels of total Abeta in cerebrospinal fluid of patients with Alzheimer 's _ disease .
8940020	0	AF12198	0,7	IL-1	145,149	AF12198	IL-1	null	3552	Chemical	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	AF12198 , a novel low molecular weight antagonist , selectively binds the human type I interleukin -LRB- IL -RRB- -1 receptor and blocks in vivo responses to IL-1 .
17545071	0	AF172993	1,9	Plunc	22,27	AF172993	Plunc	null	51297	Chemical	Gene	sequence|compound|START_ENTITY sequence|nmod|END_ENTITY	-LSB- AF172993 sequence of Plunc in GenBank database is not the complete CDS -RSB- .
12118039	0	AF2	24,27	glucocorticoid_receptor	58,81	AF2	glucocorticoid receptor	MESH:D005668	2908	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	A point mutation of the AF2 transactivation domain of the glucocorticoid_receptor disrupts its interaction with steroid_receptor_coactivator_1 .
6124269	0	AFB1	33,37	GGT	41,44	AFB1	GGT	null	116568(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Effect of microsomally activated AFB1 on GGT activity in 3 rat liver cell lines .
21316452	0	AFQ056	0,6	mGluR5	14,20	AFQ056	mGluR5	MESH:C581397	14805(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	AFQ056 , a new mGluR5 antagonist for treatment of fragile_X_syndrome .
23775850	0	AFQ056	101,107	mGluR5	80,86	AFQ056	mGluR5	MESH:C581397	14805(Tax:10090)	Chemical	Gene	mavoglurant|appos|START_ENTITY mavoglurant|amod|antagonist antagonist|dep|END_ENTITY	Metabolism and disposition of the metabotropic glutamate receptor 5 antagonist -LRB- mGluR5 -RRB- mavoglurant -LRB- AFQ056 -RRB- in healthy subjects .
25943176	0	AFQ056	23,29	mGluR5	44,50	AFQ056	mGluR5	MESH:C581397	14805(Tax:10090)	Chemical	Gene	Effect|appos|START_ENTITY Effect|appos|antagonist antagonist|amod|END_ENTITY	Effect of mavoglurant -LRB- AFQ056 -RRB- , a selective mGluR5 antagonist , on the pharmacokinetics of a combined oral contraceptive containing ethinyl_estradiol and levonorgestrel in healthy women .
9657136	0	AFT024	29,35	CD38	68,72	AFT024	CD38	null	952	Chemical	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	The murine stromal cell line AFT024 acts specifically on human CD34 + CD38 - progenitors to maintain primitive function and immunophenotype in vitro .
17371720	0	AG-013736	0,9	VEGF	32,36	AG-013736	VEGF	MESH:C503983	7422	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|kinases kinases|compound|END_ENTITY	AG-013736 , a novel inhibitor of VEGF receptor tyrosine kinases , inhibits breast_cancer growth and decreases vascular permeability as detected by dynamic contrast-enhanced magnetic resonance imaging .
15494718	0	AG1024	26,32	Bcr-Abl	82,89	AG1024	Bcr-Abl	MESH:C447031	25	Chemical	Gene	exerts|nsubj|START_ENTITY exerts|nmod|END_ENTITY	Tyrosine_kinase inhibitor AG1024 exerts antileukaemic effects on STI571-resistant Bcr-Abl expressing cells and decreases AKT phosphorylation .
15178645	6	AG1478	909,915	EGFR	893,897	AG1478	PTTG	MESH:C101044	9232	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	PTTG induction by EGF_receptor -LRB- EGFR -RRB- ligands could be blocked by the specific EGFR inhibitor , AG1478 .
16203806	0	AG1478	173,179	EGFR	121,125	AG1478	EGFR	MESH:C101044	1956	Chemical	Gene	tyrosine|dobj|START_ENTITY tyrosine|nsubj|efficacy efficacy|nmod|radioimmunotherapy radioimmunotherapy|nmod|90Y-CHX-A 90Y-CHX-A|amod|DTPA-hu3S193 DTPA-hu3S193|nmod|inhibition inhibition|nmod|epidermal_growth_factor_receptor epidermal_growth_factor_receptor|appos|END_ENTITY	Enhanced efficacy of radioimmunotherapy with 90Y-CHX-A '' - DTPA-hu3S193 by inhibition of epidermal_growth_factor_receptor -LRB- EGFR -RRB- signaling with EGFR tyrosine kinase inhibitor AG1478 .
16203806	0	AG1478	173,179	EGFR	142,146	AG1478	EGFR	MESH:C101044	1956	Chemical	Gene	tyrosine|dobj|START_ENTITY tyrosine|nsubj|efficacy efficacy|nmod|radioimmunotherapy radioimmunotherapy|nmod|90Y-CHX-A 90Y-CHX-A|amod|DTPA-hu3S193 DTPA-hu3S193|nmod|inhibition inhibition|nmod|epidermal_growth_factor_receptor epidermal_growth_factor_receptor|dep|signaling signaling|nmod|END_ENTITY	Enhanced efficacy of radioimmunotherapy with 90Y-CHX-A '' - DTPA-hu3S193 by inhibition of epidermal_growth_factor_receptor -LRB- EGFR -RRB- signaling with EGFR tyrosine kinase inhibitor AG1478 .
17092939	0	AG1478	70,76	EGFR	124,128	AG1478	EGFR	MESH:C101044	1956	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|formation formation|nmod|dimers dimers|compound|END_ENTITY	The epidermal_growth_factor_receptor -LRB- EGFR -RRB- tyrosine kinase inhibitor AG1478 increases the formation of inactive untethered EGFR dimers .
17092939	0	AG1478	70,76	EGFR	38,42	AG1478	EGFR	MESH:C101044	1956	Chemical	Gene	increases|nsubj|START_ENTITY tyrosine|ccomp|increases tyrosine|nsubj|epidermal_growth_factor_receptor epidermal_growth_factor_receptor|appos|END_ENTITY	The epidermal_growth_factor_receptor -LRB- EGFR -RRB- tyrosine kinase inhibitor AG1478 increases the formation of inactive untethered EGFR dimers .
17286987	9	AG1478	1155,1161	EGFR	1222,1226	AG1478	VEGF	MESH:C101044	83785(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|kinase kinase|appos|END_ENTITY	Furthermore , AG1478 , a selective inhibitor of epidermal_growth_factor_receptor -LRB- EGFR -RRB- kinase , inhibited nicotine-induced ERK phosphorylation and VEGF release .
17409374	3	AG1478	1078,1084	EGFR	1026,1030	AG1478	EGFR	MESH:C101044	396494(Tax:9031)	Chemical	Gene	epidermal_growth_factor_receptor|appos|START_ENTITY epidermal_growth_factor_receptor|appos|END_ENTITY	Treatment of undifferentiated granulosa cells with a selective epidermal_growth_factor_receptor -LRB- EGFR -RRB- and ERBB4 receptor tyrosine kinase inhibitor -LRB- AG1478 -RRB- both augments FSH_receptor -LRB- Fshr -RRB- mRNA expression and initiates progesterone production .
19059384	0	AG1478	81,87	EGFR	50,54	AG1478	EGFR	MESH:C101044	1956	Chemical	Gene	kinase|dobj|START_ENTITY kinase|csubj|Inhibiting Inhibiting|nmod|tyrosine tyrosine|amod|END_ENTITY	Inhibiting the function of ABCB1 and ABCG2 by the EGFR tyrosine kinase inhibitor AG1478 .
24023306	0	AG1478	50,56	EGFR	92,96	AG1478	EGFR	MESH:C101044	1956	Chemical	Gene	Combination|nmod|START_ENTITY Combination|dep|effect effect|nmod|phosphorylation phosphorylation|amod|END_ENTITY	Combination of the EGFR tyrosine kinase inhibitor AG1478 and 5-FU : no synergistic effect on EGFR phosphorylation , cell proliferation and apoptosis induction .
11565870	0	AG1478	133,139	epidermal_growth_factor_receptor	69,101	AG1478	epidermal growth factor receptor	MESH:C101044	1956	Chemical	Gene	inhibitor|compound|START_ENTITY cisplatin|nmod|inhibitor sensitized|xcomp|cisplatin END_ENTITY|acl|sensitized	Human glioblastoma xenografts overexpressing a tumor-specific mutant epidermal_growth_factor_receptor sensitized to cisplatin by the AG1478 tyrosine kinase inhibitor .
23099861	0	AG1478	56,62	epidermal_growth_factor_receptor	13,45	AG1478	epidermal growth factor receptor	MESH:C101044	1956	Chemical	Gene	START_ENTITY|nsubj|Influence Influence|nmod|inhibitor inhibitor|compound|END_ENTITY	Influence of epidermal_growth_factor_receptor inhibitor AG1478 on epithelial-mesenchymal transition in endometrial_carcinoma cells .
8612303	0	AG337	0,5	thymidylate_synthase	26,46	AG337	thymidylate synthase	MESH:C099178	22171(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	AG337 , a novel lipophilic thymidylate_synthase inhibitor : in vitro and in vivo preclinical studies .
9845097	0	AG337	110,115	thymidylate_synthase	136,156	AG337	thymidylate synthase	MESH:C099178	22171(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	The potentiation of radiation response in human colon_carcinoma cells in vitro and murine lymphoma in vivo by AG337 -LRB- Thymitaq -RRB- , a novel thymidylate_synthase inhibitor .
18695355	0	AG490	0,5	Akt	80,83	AG490	Akt	MESH:C095512	207	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|activating activating|dobj|END_ENTITY	AG490 , a Jak2-specific inhibitor , induces osteoclast survival by activating the Akt and ERK signaling pathways .
16934228	0	AG490	58,63	IL-1beta	15,23	AG490	IL-1beta	MESH:C095512	24494(Tax:10116)	Chemical	Gene	Suppression|nmod|START_ENTITY Suppression|nmod|expression expression|compound|END_ENTITY	Suppression of IL-1beta expression by the Jak_2 inhibitor AG490 in cerulein-stimulated pancreatic acinar cells .
19281795	0	AG490	18,23	Jak2	2,6	AG490	Jak2	MESH:C095512	3717	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	A Jak2 inhibitor , AG490 , reverses lipin-1 suppression by TNF-alpha in 3T3-L1 adipocytes .
26410360	0	AG490	0,5	Jak2	9,13	AG490	Jak2	MESH:C095512	16452(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	AG490 , a Jak2 inhibitor , suppressed the progression of murine ovarian_cancer .
23665018	0	AG490	0,5	NFATc1	15,21	AG490	NFATc1	MESH:C095512	18018(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	AG490 inhibits NFATc1 expression and STAT3 activation during RANKL induced osteoclastogenesis .
17054436	0	AG490	34,39	STAT3	14,19	AG490	STAT3	MESH:C095512	6774	Chemical	Gene	activity|nmod|START_ENTITY activity|nummod|END_ENTITY	Inhibition of STAT3 activity with AG490 decreases the invasion of human pancreatic_cancer cells in vitro .
27064043	15	AG490	2450,2455	STAT3	2380,2385	AG490	IL-10	MESH:C095512	25325(Tax:10116)	Chemical	Gene	upregulated|nmod|START_ENTITY upregulated|nsubjpass|END_ENTITY	Phosphorylated STAT3 was upregulated after IL-10 infusion and inhibition of STAT3 by AG490 reversed the therapeutic effect of IL-10 .
17005185	0	AGE-BSA	0,7	ABCG1	18,23	AGE-BSA	ABCG1	null	9619	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|compound|END_ENTITY	AGE-BSA decreases ABCG1 expression and reduces macrophage cholesterol efflux to HDL .
16144662	0	AGN-2979	49,57	tryptophan_hydroxylase	4,26	AGN-2979	tryptophan hydroxylase	MESH:C048715	24848(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	The tryptophan_hydroxylase activation inhibitor , AGN-2979 , decreases regional 5-HT synthesis in the rat brain measured with alpha - -LSB- 14C -RSB- methyl-L-tryptophan : an autoradiographic study .
19463878	0	AGN-2979	0,8	tryptophan_hydroxylase	26,48	AGN-2979	tryptophan hydroxylase	MESH:C048715	24848(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|activation activation|amod|END_ENTITY	AGN-2979 , an inhibitor of tryptophan_hydroxylase activation , does not affect serotonin synthesis in Flinders Sensitive Line rats , a rat model of depression , but produces a significant effect in Flinders Resistant Line rats .
16891465	0	AGRO100	0,7	nuclear_factor-kappaB	31,52	AGRO100	nuclear factor-kappaB	MESH:C513936	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	AGRO100 inhibits activation of nuclear_factor-kappaB -LRB- NF-kappaB -RRB- by forming a complex with NF-kappaB_essential_modulator -LRB- NEMO -RRB- and nucleolin .
14981926	0	AH66	136,140	multidrug_resistance-associated_protein_2	29,70	AH66	multidrug resistance-associated protein 2	null	25303(Tax:10116)	Chemical	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Conjugated bilirubin induces multidrug_resistance-associated_protein_2 mRNA expression and in vivo cisplatin resistance in rat hepatoma AH66 cells .
6315003	0	AH_22216	42,50	HGT-1	115,120	AH 22216	HGT-1	MESH:C038304	8034	Chemical	Gene	inactivation|nmod|START_ENTITY inactivation|nmod|END_ENTITY	Irreversible and specific inactivation by AH_22216 of histamine H2 receptors in the human gastric_cancer cell line HGT-1 .
8444284	0	AJ-2615	0,7	Ca2	23,26	AJ-2615	Ca2	MESH:C067818	760	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	AJ-2615 , a long-acting Ca2 + channel antagonist with a novel structure .
25579091	0	AK106-001616	70,82	cPLA2	54,59	AK106-001616	cPLA2	null	5321	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Evaluation of drug-drug interaction between the novel cPLA2 inhibitor AK106-001616 and methotrexate in rheumatoid_arthritis patients .
16258590	0	AKBA	50,54	5-LOX	56,61	AKBA	5-LOX	null	11689(Tax:10090)	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|compound|END_ENTITY	Protective effects of nimesulide -LRB- COX Inhibitor -RRB- , AKBA -LRB- 5-LOX Inhibitor -RRB- , and their combination in aging-associated abnormalities in mice .
18619724	0	AKR-501	0,7	thrombopoietin	36,50	AKR-501	thrombopoietin	MESH:C533238	7066	Chemical	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	AKR-501 -LRB- YM477 -RRB- in combination with thrombopoietin enhances human megakaryocytopoiesis .
19183407	0	AKR-501	0,7	thrombopoietin	38,52	AKR-501	thrombopoietin	MESH:C533238	7066	Chemical	Gene	agonist|nsubj|START_ENTITY agonist|nsubj|receptor receptor|compound|END_ENTITY	AKR-501 -LRB- YM477 -RRB- a novel orally-active thrombopoietin receptor agonist .
8510341	6	ALA-B	1018,1023	ALA-D	1076,1081	ALA-B	ALA-D	null	210	Chemical	Gene	START_ENTITY|nmod|activity activity|appos|END_ENTITY	In the workers , the correlation coefficients of ALA-B vs. Pb-B and ALA-B vs. delta-aminolevulinic_acid dehydratase activity -LRB- ALA-D -RRB- were higher than those of urinary concentration of ALA vs. Pb-B and that vs. ALA-D , especially in the moderate Pb-B level -LRB- less than 40 micrograms/dl , n = 35 -RRB- .
24907534	0	ALA-PDT	28,35	coproporphyrinogen_oxidase	77,103	ALA-PDT	coproporphyrinogen oxidase	null	1371	Chemical	Gene	START_ENTITY|nmod|up-regulation up-regulation|nmod|END_ENTITY	Improve efficacy of topical ALA-PDT by calcipotriol through up-regulation of coproporphyrinogen_oxidase .
26375138	0	ALCOHOL	21,28	IL-6	60,64	ALCOHOL	IL-6	D000431	3569	Chemical	Gene	LEVELS|compound|START_ENTITY LEVELS|compound|END_ENTITY	T-15 : POSITIVE BLOOD ALCOHOL CONCENTRATIONS AFFECT SYSTEMIC IL-6 LEVELS AND LEUKOCYTE COUNTS AFTER SEVERE TRAUMATIC BRAIN INJURY .
26102715	0	ALDOSTERONE	37,48	RENIN	59,64	ALDOSTERONE	RENIN	MESH:D000450	5972	Chemical	Gene	RATIO|compound|START_ENTITY RATIO|compound|END_ENTITY	9B .07 : EFFECT OF POSTURAL CHANGES ON ALDOSTERONE TO PLASMA RENIN RATIO IN PATIENTS WITH SUSPECTED SECONDARY HYPERTENSION .
10336516	0	ALE-0540	45,53	nerve_growth_factor	63,82	ALE-0540	nerve growth factor	MESH:C119320	310738(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Characterization of antiallodynic actions of ALE-0540 , a novel nerve_growth_factor receptor antagonist , in the rat .
11975681	0	ALRT_1550	12,21	interferon-gamma	44,60	ALRT 1550	interferon-gamma	MESH:C100800	3458	Chemical	Gene	Activity|nmod|START_ENTITY Activity|nmod|END_ENTITY	Activity of ALRT_1550 , a new retinoid , with interferon-gamma on ovarian_cancer cell lines .
21612515	0	ALT-711	50,57	thiamine_diphosphokinase	89,113	ALT-711	thiamine diphosphokinase	MESH:C406794	27010	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	The advanced glycation end product-lowering agent ALT-711 is a low-affinity inhibitor of thiamine_diphosphokinase .
16148445	0	AM-251	22,28	CB1	54,57	AM-251	CB1	MESH:C103505	12801(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Anxiogenic profile of AM-251 , a selective cannabinoid CB1 receptor antagonist , in plus-maze-na ve and plus-maze-experienced mice .
26609670	0	AM-251	107,113	CB1	78,81	AM-251	CB1	MESH:C103505	12801(Tax:10090)	Chemical	Gene	agonist|dobj|START_ENTITY agonist|nsubj|Involvement Involvement|nmod|system system|nmod|effect effect|nmod|inverse inverse|compound|END_ENTITY	Involvement of opioid system in antidepressant-like effect of the cannabinoid CB1 receptor inverse agonist AM-251 after physical stress in mice .
21382397	0	AM1710	36,42	CB2	67,70	AM1710	CB2	MESH:C500321	1269	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Pharmacological characterization of AM1710 , a putative cannabinoid CB2 agonist from the cannabilactone class : antinociception without central nervous system side-effects .
14665974	0	AM251	90,95	CB1	61,64	AM251	CB1	MESH:C103505	12801(Tax:10090)	Chemical	Gene	agonist|dobj|START_ENTITY agonist|nsubj|effects effects|nmod|inverse inverse|compound|END_ENTITY	Antidepressant-like and anorectic effects of the cannabinoid CB1 receptor inverse agonist AM251 in mice .
16464439	0	AM251	0,5	CB1	37,40	AM251	CB1	MESH:C103505	25248(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|nmod|receptor receptor|compound|END_ENTITY	AM251 , a selective antagonist of the CB1 receptor , inhibits the induction of long-term potentiation and induces retrograde_amnesia in rats .
16828068	0	AM251	56,61	CB1	15,18	AM251	CB1	MESH:C103505	12801(Tax:10090)	Chemical	Gene	cannabinoid|dobj|START_ENTITY cannabinoid|nsubj|Effects Effects|nmod|END_ENTITY	Effects of the CB1 cannabinoid receptor inverse agonist AM251 on food intake and body weight in mice lacking mu-opioid receptors .
18191122	0	AM251	97,102	CB1	80,83	AM251	CB1	MESH:C103505	12801(Tax:10090)	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|administration administration|nmod|cannabinoid_receptor cannabinoid_receptor|appos|END_ENTITY	Antidiabetic effects of sub-chronic administration of the cannabinoid_receptor -LRB- CB1 -RRB- antagonist , AM251 , in obese diabetic -LRB- ob/ob -RRB- mice .
19804815	0	AM251	30,35	CB1	37,40	AM251	CB1	MESH:C103505	25248(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Sub-chronic administration of AM251 , CB1 receptor antagonist , within the nucleus accumbens induced sensitization to morphine in the rat .
20347865	3	AM251	408,413	CB1	445,448	AM251	CB1	MESH:C103505	25248(Tax:10116)	Chemical	Gene	referred|nsubjpass|START_ENTITY referred|nmod|antagonist antagonist|compound|END_ENTITY	AM251 is frequently referred to as a CB1 antagonist ; however in vitro signal transduction assays indicate that this drug also elicits inverse agonist activity at CB1 receptors .
8836622	0	AM251	13,18	CB1	91,94	AM251	CB1	MESH:C103505	12801(Tax:10090)	Chemical	Gene	START_ENTITY|dep|ligand ligand|acl:relcl|binds binds|nmod|brain brain|acl|cannabinoid cannabinoid|dobj|receptors receptors|nummod|END_ENTITY	123I-labeled AM251 : a radioiodinated ligand which binds in vivo to mouse brain cannabinoid CB1 receptors .
21449913	0	AM251	41,46	EGF_receptor	79,91	AM251	EGF receptor	MESH:C103505	1956	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	The cannabinoid receptor inverse agonist AM251 regulates the expression of the EGF_receptor and its ligands via destabilization of oestrogen-related receptor a protein .
15914321	0	AM3	0,3	iNOS	25,29	AM3	iNOS	MESH:C038773	18126(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	AM3 inhibits LPS-induced iNOS expression in mice .
16608770	0	AM3	11,14	interleukin-6	66,79	AM3	interleukin-6	MESH:C038773	3569	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|concentrations concentrations|nmod|END_ENTITY	Effects of AM3 -LRB- Inmunoferon -RRB- on increased serum concentrations of interleukin-6 and tumour necrosis factor receptors I and II in cyclists .
17521686	7	AM4113	1363,1369	CB1	1457,1460	AM4113	CB1	MESH:C529765	25248(Tax:10116)	Chemical	Gene	produces|nsubj|START_ENTITY produces|dobj|effects effects|acl:relcl|similar similar|nmod|those those|acl|produced produced|nmod|agonists agonists|nummod|END_ENTITY	Across a variety of different tests , AM4113 produces effects on food-motivated behavior that are very similar to those produced by CB1 inverse agonists .
18640150	0	AM4113	21,27	CB1	48,51	AM4113	CB1	MESH:C529765	25248(Tax:10116)	Chemical	Gene	START_ENTITY|appos|receptor receptor|compound|END_ENTITY	Intrinsic effects of AM4113 , a putative neutral CB1 receptor selective antagonist , on open-field behaviors in rats .
18703081	0	AM4113	126,132	CB1	46,49	AM4113	CB1	MESH:C529765	1268	Chemical	Gene	cannabinoid|nmod|START_ENTITY cannabinoid|dobj|AM6527 AM6527|compound|END_ENTITY	Oral bioavailability of the novel cannabinoid CB1 antagonist AM6527 : effects on food-reinforced behavior and comparisons with AM4113 .
20015619	0	AM4113	115,121	CB1	44,47	AM4113	CB1	MESH:C529765	25248(Tax:10116)	Chemical	Gene	comparisons|nmod|START_ENTITY effects|dep|comparisons effects|nmod|agonists agonists|compound|END_ENTITY	Potential anxiogenic effects of cannabinoid CB1 receptor antagonists/inverse agonists in rats : comparisons between AM4113 , AM251 , and the benzodiazepine inverse agonist FG-7142 .
25473215	0	AMD-3100	63,71	Flap	93,97	AMD-3100	Flap	MESH:C088327	29624(Tax:10116)	Chemical	Gene	Induced|nmod|START_ENTITY Induced|nmod|END_ENTITY	Effect of Endogenous Bone Marrow Derived Stem Cells Induced by AMD-3100 on Expanded Ischemic Flap .
17452489	0	AMD070	94,100	CXCR4	114,119	AMD070	CXCR4	MESH:C494414	7852	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Multiple-dose escalation study of the safety , pharmacokinetics , and biologic activity of oral AMD070 , a selective CXCR4 receptor inhibitor , in human subjects .
18362694	0	AMD070	26,32	CXCR4	42,47	AMD070	CXCR4	MESH:C494414	7852	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Pharmacokinetic effect of AMD070 , an Oral CXCR4 antagonist , on CYP3A4 and CYP2D6 substrates midazolam and dextromethorphan in healthy volunteers .
26801174	6	AMD3100	1192,1199	CXCL12	1181,1187	AMD3100	CXCL12	MESH:C088327	24772(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY treatment|compound|END_ENTITY	CXCL12 + AMD3100 treatment significantly decreased the number and distribution area of CXCR4/DCX and MMP-2 positive cells compared with the CXCL12 treatment and control group .
11408611	2	AMD3100	441,448	CXCR4	454,459	AMD3100	CXCR4	MESH:C088327	7852	Chemical	Gene	interaction|nmod|START_ENTITY investigated|dobj|interaction investigated|nmod|END_ENTITY	Here , we investigated the interaction of AMD3100 with CXCR4 at the molecular level by mutational analysis .
11591799	0	AMD3100	0,7	CXCR4	98,103	AMD3100	CXCR4	MESH:C088327	12767(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|nmod|END_ENTITY	AMD3100 , a potent and specific antagonist of the stromal cell-derived factor-1 chemokine receptor CXCR4 , inhibits autoimmune_joint_inflammation in IFN-gamma receptor-deficient mice .
12220670	0	AMD3100	33,40	CXCR4	65,70	AMD3100	CXCR4	MESH:C088327	7852	Chemical	Gene	inhibition|nmod|START_ENTITY confined|nsubjpass|inhibition confined|nmod|END_ENTITY	Chemokine_receptor inhibition by AMD3100 is strictly confined to CXCR4 .
12534283	0	AMD3100	30,37	CXCR4	55,60	AMD3100	CXCR4	MESH:C088327	7852	Chemical	Gene	binding|nmod|START_ENTITY enhanced|xcomp|binding enhanced|nmod|Asp262 Asp262|nmod|receptor receptor|compound|END_ENTITY	Metal ion enhanced binding of AMD3100 to Asp262 in the CXCR4 receptor .
12832058	0	AMD3100	45,52	CXCR4	17,22	AMD3100	CXCR4	MESH:C088327	7852	Chemical	Gene	sites|nmod|START_ENTITY sites|nummod|END_ENTITY	Mutations at the CXCR4 interaction sites for AMD3100 influence anti-CXCR4 antibody binding and HIV-1 entry .
12855591	0	AMD3100	72,79	CXCR4	83,88	AMD3100	CXCR4	MESH:C088327	7852	Chemical	Gene	Mobilization|nmod|START_ENTITY antagonist|advcl|Mobilization antagonist|nsubj|END_ENTITY	Mobilization of hematopoietic progenitor cells in healthy volunteers by AMD3100 , a CXCR4 antagonist .
14585837	0	AMD3100	23,30	CXCR4	49,54	AMD3100	CXCR4	MESH:C088327	7852	Chemical	Gene	antagonism|compound|START_ENTITY antagonism|nmod|receptor receptor|compound|END_ENTITY	Molecular mechanism of AMD3100 antagonism in the CXCR4 receptor : transfer of binding site to the CXCR3 receptor .
15752146	0	AMD3100	183,190	CXCR4	194,199	AMD3100	CXCR4	MESH:C088327	7852	Chemical	Gene	administration|nmod|START_ENTITY stimulated|nmod|administration stimulated|dobj|antagonist antagonist|compound|END_ENTITY	Augmented mobilization and collection of CD34 + hematopoietic cells from normal human volunteers stimulated with granulocyte-colony-stimulating_factor by single-dose administration of AMD3100 , a CXCR4 antagonist .
15837815	0	AMD3100	84,91	CXCR4	95,100	AMD3100	CXCR4	MESH:C088327	7852	Chemical	Gene	cells|nmod|START_ENTITY stem|dobj|cells stem|xcomp|antagonist antagonist|compound|END_ENTITY	Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100 , a CXCR4 antagonist .
16269859	0	AMD3100	48,55	CXCR4	8,13	AMD3100	CXCR4	MESH:C088327	7852	Chemical	Gene	using|dobj|START_ENTITY blockade|acl|using chemokine|dobj|blockade chemokine|nsubj|Role Role|nmod|END_ENTITY	Role of CXCR4 chemokine receptor blockade using AMD3100 for mobilization of autologous hematopoietic progenitor cells .
16787495	0	AMD3100	24,31	CXCR4	154,159	AMD3100	CXCR4	MESH:C088327	12767(Tax:10090)	Chemical	Gene	analogues|nmod|START_ENTITY mobilise|nsubj|analogues mobilise|nmod|ability ability|acl|inhibit inhibit|xcomp|binding binding|nmod|END_ENTITY	Structural analogues of AMD3100 mobilise haematopoietic progenitor cells from bone marrow in vivo according to their ability to inhibit CXCL12 binding to CXCR4 in vitro .
16815309	0	AMD3100	50,57	CXCR4	126,131	AMD3100	CXCR4	MESH:C088327	7852	Chemical	Gene	pharmacology|nmod|START_ENTITY Characterization|nmod|pharmacology Characterization|dep|antagonist antagonist|nmod|receptor receptor|appos|END_ENTITY	Characterization of the molecular pharmacology of AMD3100 : a specific antagonist of the G-protein coupled chemokine receptor , CXCR4 .
16974072	4	AMD3100	928,935	CXCR4	1030,1035	AMD3100	SDF-1	MESH:C088327	24772(Tax:10116)	Chemical	Gene	DMCs|nmod|START_ENTITY Incubation|nmod|DMCs Incubation|acl:relcl|blocks blocks|dobj|binding binding|nmod|END_ENTITY	Incubation of DMCs with AMD3100 before transplantation , which specifically blocks binding of SDF-1 to its endogenous receptor CXCR4 , diminished recruitment of DMCs to the injured BM by 57.2 + / - 5.5 % -LRB- P < 0.05 -RRB- .
17053169	7	AMD3100	1264,1271	CXCR4	1246,1251	AMD3100	M-CSF	MESH:C088327	12977(Tax:10090)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	Further , a novel CXCR4 antagonist , AMD3100 , significantly attenuated the M-CSF-induced neointimal formation .
17280498	0	AMD3100	0,7	CXCR4	9,14	AMD3100	CXCR4	MESH:C088327	7852	Chemical	Gene	START_ENTITY|parataxis|stem stem|nsubj|END_ENTITY	AMD3100 : CXCR4 antagonist and rapid stem cell-mobilizing agent .
17442973	0	AMD3100	15,22	CXCR4	26,31	AMD3100	CXCR4	MESH:C088327	12767(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|antagonist antagonist|compound|END_ENTITY	Dual effect of AMD3100 , a CXCR4 antagonist , on bleomycin-induced lung_inflammation .
18416455	0	AMD3100	34,41	CXCR4	14,19	AMD3100	CXCR4	MESH:C088327	7852	Chemical	Gene	activity|nmod|START_ENTITY activity|nummod|END_ENTITY	Inhibition of CXCR4 activity with AMD3100 decreases invasion of human colorectal_cancer cells in vitro .
18443125	0	AMD3100	86,93	CXCR4	127,132	AMD3100	CXCR4	MESH:C088327	7852	Chemical	Gene	human_immunodeficiency_virus_type_1|nmod|START_ENTITY Suppression|nmod|human_immunodeficiency_virus_type_1 associated|nsubjpass|Suppression associated|nmod|efficiency efficiency|nmod|use use|amod|END_ENTITY	Suppression of dualtropic human_immunodeficiency_virus_type_1 by the CXCR4 antagonist AMD3100 is associated with efficiency of CXCR4 use and baseline virus composition .
18628138	0	AMD3100	73,80	CXCR4	84,89	AMD3100	CXCR4	MESH:C088327	7852	Chemical	Gene	START_ENTITY|appos|Antagonist Antagonist|compound|END_ENTITY	Leukocytosis and Mobilization of CD34 + Hematopoietic Progenitor Cells by AMD3100 , a CXCR4 Antagonist .
19050309	0	AMD3100	98,105	CXCR4	81,86	AMD3100	CXCR4	MESH:C088327	12767(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Chemosensitization Chemosensitization|nmod|mobilization mobilization|nmod|antagonist antagonist|compound|END_ENTITY	Chemosensitization of acute_myeloid_leukemia -LRB- AML -RRB- following mobilization by the CXCR4 antagonist AMD3100 .
19451305	0	AMD3100	168,175	CXCR4	10,15	AMD3100	CXCR4	MESH:C088327	7852	Chemical	Gene	studies|nmod|START_ENTITY inhibitor|dep|studies inhibitor|nsubj|KRH-3955 KRH-3955|nummod|END_ENTITY	The novel CXCR4 antagonist KRH-3955 is an orally bioavailable and extremely potent inhibitor of human_immunodeficiency_virus_type_1_infection : comparative studies with AMD3100 .
20556832	0	AMD3100	17,24	CXCR4	0,5	AMD3100	CXCR4	MESH:C088327	12767(Tax:10090)	Chemical	Gene	attenuates|compound|START_ENTITY attenuates|compound|END_ENTITY	CXCR4 antagonist AMD3100 attenuates colonic_damage in mice with experimental colitis .
20826182	0	AMD3100	63,70	CXCR4	34,39	AMD3100	CXCR4	MESH:C088327	7852	Chemical	Gene	plerixafor|appos|START_ENTITY plerixafor|compound|END_ENTITY	Recent advances on the use of the CXCR4 antagonist plerixafor -LRB- AMD3100 , Mozobil -RRB- and potential of other CXCR4 antagonists as stem cell mobilizers .
20938660	0	AMD3100	94,101	CXCR4	57,62	AMD3100	CXCR4	MESH:C088327	7852	Chemical	Gene	plerixafor|appos|START_ENTITY plerixafor|compound|END_ENTITY	Hematopoietic stem cell mobilization with the reversible CXCR4 receptor inhibitor plerixafor -LRB- AMD3100 -RRB- - Polish compassionate use experience .
21070597	0	AMD3100	0,7	CXCR4	34,39	AMD3100	CXCR4	MESH:C088327	7852	Chemical	Gene	antagonist|nsubj|START_ENTITY antagonist|nmod|END_ENTITY	AMD3100 is a potent antagonist at CXCR4 -LRB- R334X -RRB- , a hyperfunctional mutant chemokine_receptor and cause of WHIM_syndrome .
21729582	0	AMD3100	44,51	CXCR4	27,32	AMD3100	CXCR4	MESH:C088327	7852	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Some research progress of CXCR4 antagonist AMD3100 -RSB- .
21998043	0	AMD3100	42,49	CXCR4	79,84	AMD3100	CXCR4	MESH:C088327	7852	Chemical	Gene	derivative|nmod|START_ENTITY Evaluation|nmod|derivative Evaluation|nmod|receptor receptor|compound|END_ENTITY	Evaluation of a fluorescent derivative of AMD3100 and its interaction with the CXCR4 chemokine receptor .
22592891	0	AMD3100	28,35	CXCR4	60,65	AMD3100	CXCR4	MESH:C088327	12767(Tax:10090)	Chemical	Gene	administration|nmod|START_ENTITY administration|appos|antagonist antagonist|nmod|signaling signaling|compound|END_ENTITY	Long-term administration of AMD3100 , an antagonist of SDF-1 / CXCR4 signaling , alters fracture repair .
22952424	0	AMD3100	22,29	CXCR4	0,5	AMD3100	CXCR4	MESH:C088327	7852	Chemical	Gene	sensitizes|nummod|START_ENTITY inhibition|nmod|sensitizes inhibition|nummod|END_ENTITY	CXCR4 inhibition with AMD3100 sensitizes prostate_cancer to docetaxel chemotherapy .
23522974	0	AMD3100	16,23	CXCR4	46,51	AMD3100	CXCR4	MESH:C088327	12767(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|tracer tracer|nmod|imaging imaging|compound|END_ENTITY	-LSB- ______ mTc -RSB- O - AMD3100 as a SPECT tracer for CXCR4 receptor imaging .
25163538	0	AMD3100	51,58	CXCR4	62,67	AMD3100	CXCR4	MESH:C088327	12767(Tax:10090)	Chemical	Gene	axis|nmod|START_ENTITY Inhibition|nmod|axis Inhibition|appos|inhibitor inhibitor|compound|END_ENTITY	Inhibition of the CXCL12/CXCR4 chemokine axis with AMD3100 , a CXCR4 small molecule inhibitor , worsens murine hepatic_injury .
25640878	0	AMD3100	4,11	CXCR4	28,33	AMD3100	CXCR4	MESH:C088327	7852	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|receptor receptor|nummod|END_ENTITY	New AMD3100 derivatives for CXCR4 chemokine receptor targeted molecular imaging studies : synthesis , anti-HIV-1 evaluation and binding affinities .
25732515	0	AMD3100	173,180	CXCR4	137,142	AMD3100	CXCR4	MESH:C088327	12767(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Attenuation Attenuation|nmod|Mice Mice|acl|blocking blocking|dobj|Receptor Receptor|appos|END_ENTITY	Attenuation of Cartilage Pathogenesis in Post-traumatic_Osteoarthritis -LRB- PTOA -RRB- in Mice by blocking the Stromal Derived Factor 1 Receptor -LRB- CXCR4 -RRB- with the specific inhibitor , AMD3100 .
25801950	0	AMD3100	17,24	CXCR4	0,5	AMD3100	CXCR4	MESH:C088327	12767(Tax:10090)	Chemical	Gene	redistributes|compound|START_ENTITY redistributes|compound|END_ENTITY	CXCR4 antagonist AMD3100 redistributes leukocytes from primary immune organs to secondary immune organs , lung , and blood in mice .
26031530	0	AMD3100	51,58	CXCR4	18,23	AMD3100	CXCR4	MESH:C088327	7852	Chemical	Gene	signal|nmod|START_ENTITY signal|nsubj|Effects Effects|nmod|END_ENTITY	-LSB- Effects of SDF-1 / CXCR4 signal pathway blockade by AMD3100 on the adhesion of leukemia cells to osteoblast niche and the drug resistance of leukemia cells -RSB- .
26347749	10	AMD3100	2038,2045	CXCR4	1919,1924	AMD3100	CXCR4	MESH:C088327	7852	Chemical	Gene	approved|nsubjpass|START_ENTITY important|advcl|approved important|advcl|diversity diversity|nmod|ligands ligands|compound|END_ENTITY	Detailed insight into biological effects of CXCR4 signaling und underlying mechanisms , including diversity of CXCR4 ligands and inter-connections with other -LRB- chemokine -RRB- receptors , is clinically important , as the CXCR4 antagonist AMD3100 has been approved as stem cell mobilizer in specific disease settings .
26347749	10	AMD3100	2038,2045	CXCR4	1919,1924	AMD3100	CXCR4	MESH:C088327	7852	Chemical	Gene	approved|nsubjpass|START_ENTITY important|advcl|approved important|advcl|diversity diversity|nmod|ligands ligands|compound|END_ENTITY	Detailed insight into biological effects of CXCR4 signaling und underlying mechanisms , including diversity of CXCR4 ligands and inter-connections with other -LRB- chemokine -RRB- receptors , is clinically important , as the CXCR4 antagonist AMD3100 has been approved as stem cell mobilizer in specific disease settings .
26494555	0	AMD3100	45,52	CXCR4	64,69	AMD3100	CXCR4	MESH:C088327	7852	Chemical	Gene	combination|nmod|START_ENTITY nanotherapy|nmod|combination suppresses|nsubj|nanotherapy suppresses|dobj|expression expression|nummod|END_ENTITY	HuR-targeted nanotherapy in combination with AMD3100 suppresses CXCR4 expression , cell growth , migration and invasion in lung_cancer .
26886512	0	AMD3100	0,7	CXCR4	34,39	AMD3100	CXCR4	MESH:C088327	7852	Chemical	Gene	START_ENTITY|dep|platform platform|nmod|radiopharmaceuticals radiopharmaceuticals|nummod|END_ENTITY	AMD3100 : a versatile platform for CXCR4 targeting 68Ga-based radiopharmaceuticals .
27061747	0	AMD3100	37,44	CXCR4	20,25	AMD3100	CXCR4	MESH:C088327	12767(Tax:10090)	Chemical	Gene	antagonist|dobj|START_ENTITY antagonist|nsubj|effect effect|nmod|END_ENTITY	Antitumor effect of CXCR4 antagonist AMD3100 on the tumorigenic cell line of BHP10-3 papillary_thyroid_cancer cells .
9427609	0	AMD3100	0,7	CXCR4	59,64	AMD3100	CXCR4	MESH:C088327	7852	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|co-receptor co-receptor|compound|END_ENTITY	AMD3100 , a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor .
9882387	0	AMD3100	74,81	CXCR4	23,28	AMD3100	CXCR4	MESH:C088327	7852	Chemical	Gene	resistance|nmod|START_ENTITY has|dobj|resistance has|nsubj|T134 T134|appos|inhibitor inhibitor|compound|END_ENTITY	T134 , a small-molecule CXCR4 inhibitor , has no cross-drug resistance with AMD3100 , a CXCR4 antagonist with a different structure .
9882387	0	AMD3100	74,81	CXCR4	85,90	AMD3100	CXCR4	MESH:C088327	7852	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	T134 , a small-molecule CXCR4 inhibitor , has no cross-drug resistance with AMD3100 , a CXCR4 antagonist with a different structure .
12220670	0	AMD3100	33,40	Chemokine_receptor	0,18	AMD3100	Chemokine receptor	MESH:C088327	7852	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Chemokine_receptor inhibition by AMD3100 is strictly confined to CXCR4 .
11943720	0	AMD3100	0,7	CxCR4	11,16	AMD3100	CxCR4	MESH:C088327	12767(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	AMD3100 , a CxCR4 antagonist , attenuates allergic_lung_inflammation and airway_hyperreactivity .
22592891	0	AMD3100	28,35	SDF-1	54,59	AMD3100	SDF-1	MESH:C088327	20315(Tax:10090)	Chemical	Gene	administration|nmod|START_ENTITY administration|appos|antagonist antagonist|nmod|signaling signaling|compound|END_ENTITY	Long-term administration of AMD3100 , an antagonist of SDF-1 / CXCR4 signaling , alters fracture repair .
20655922	0	AMD3100	8,15	SDF-1alpha-CXCR4	30,46	AMD3100	SDF-1alpha-CXCR4	MESH:C088327	12767(Tax:10090)	Chemical	Gene	antagonism|compound|START_ENTITY antagonism|nmod|END_ENTITY	Chronic AMD3100 antagonism of SDF-1alpha-CXCR4 exacerbates cardiac_dysfunction and remodeling after myocardial_infarction .
16877345	0	AMD3465	0,7	CXCR4	17,22	AMD3465	CXCR4	MESH:C503590	12767(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	AMD3465 , a novel CXCR4 receptor antagonist , abrogates schistosomal antigen-elicited -LRB- type-2 -RRB- pulmonary_granuloma formation .
19540208	0	AMD3465	16,23	CXCR4	79,84	AMD3465	CXCR4	MESH:C503590	483900(Tax:9615)	Chemical	Gene	Pharmacology|nmod|START_ENTITY Pharmacology|dep|antagonist antagonist|nmod|END_ENTITY	Pharmacology of AMD3465 : a small molecule antagonist of the chemokine receptor CXCR4 .
22836051	0	AMG-458	104,111	c-Met	131,136	AMG-458	c-Met	MESH:C530596	4233	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Higher levels of c-Met expression and phosphorylation identify cell lines with increased sensitivity to AMG-458 , a novel selective c-Met inhibitor with radiosensitizing effects .
22836051	0	AMG-458	104,111	c-Met	17,22	AMG-458	c-Met	MESH:C530596	4233	Chemical	Gene	sensitivity|nmod|START_ENTITY identify|nmod|sensitivity identify|nsubj|levels levels|nmod|expression expression|amod|END_ENTITY	Higher levels of c-Met expression and phosphorylation identify cell lines with increased sensitivity to AMG-458 , a novel selective c-Met inhibitor with radiosensitizing effects .
20652976	0	AMG-479	49,56	Insulin-like_growth_factor-1_receptor	0,37	AMG-479	Insulin-like growth factor-1 receptor	null	3480	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Insulin-like_growth_factor-1_receptor inhibitor , AMG-479 , in cetuximab-refractory head_and_neck_squamous_cell_carcinoma .
25662185	0	AMG2850	0,7	TRPM8	32,37	AMG2850	TRPM8	null	171384(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	AMG2850 , a potent and selective TRPM8 antagonist , is not effective in rat models of inflammatory mechanical hypersensitivity and neuropathic_tactile_allodynia .
23998444	0	AMG888	70,76	HER3	42,46	AMG888	HER3	null	2065	Chemical	Gene	blockade|nmod|START_ENTITY blockade|compound|END_ENTITY	Human epidermal growth factor receptor 3 -LRB- HER3 -RRB- blockade with U3-1287 / AMG888 enhances the efficacy of radiation therapy in lung and head_and_neck_carcinoma .
25505557	0	AMG_076	14,21	MCHR1	46,51	AMG 076	MCHR1	MESH:C526481	207911(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Evaluation of AMG_076 , a potent and selective MCHR1 antagonist , in rodent and primate obesity models .
23129602	0	AMG_145	56,63	serine_protease	136,151	AMG 145	serine protease	null	2147	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|END_ENTITY	Low-density lipoprotein cholesterol-lowering effects of AMG_145 , a monoclonal antibody to proprotein_convertase_subtilisin / kexin_type_9 serine_protease in patients with heterozygous familial_hypercholesterolemia : the Reduction of LDL-C with PCSK9 Inhibition in Heterozygous Familial_Hypercholesterolemia_Disorder -LRB- RUTHERFORD -RRB- randomized trial .
26434934	0	AMG_151	0,7	glucokinase	28,39	AMG 151	glucokinase	null	2645	Chemical	Gene	START_ENTITY|appos|activator activator|compound|END_ENTITY	AMG_151 -LRB- ARRY-403 -RRB- , a novel glucokinase activator , decreases_fasting_and_postprandial_glycaemia in patients with type 2 diabetes .
20056900	0	AMG_317	43,50	IL-4Ralpha	55,65	AMG 317	IL-4Ralpha	null	3566	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	A randomized , controlled , phase 2 study of AMG_317 , an IL-4Ralpha antagonist , in patients with asthma .
21114421	0	AMG_785	44,51	Sclerostin	0,10	AMG 785	Sclerostin	null	50964	Chemical	Gene	therapy|nmod|START_ENTITY therapy|amod|END_ENTITY	Sclerostin monoclonal antibody therapy with AMG_785 : a potential treatment for osteoporosis .
22217876	0	AMG_837	0,7	GPR40	39,44	AMG 837	GPR40	MESH:C557933	2864	Chemical	Gene	START_ENTITY|dep|agonist agonist|compound|END_ENTITY	AMG_837 : a potent , orally bioavailable GPR40 agonist .
24091768	0	AMG_900	0,7	p53	127,130	AMG 900	p53	MESH:C555658	7157	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	AMG_900 , pan-Aurora kinase inhibitor , preferentially inhibits the proliferation of breast_cancer cell lines with dysfunctional p53 .
10443662	3	AMH	628,631	men	655,658	AMH	AMH	null	268	Chemical	Gene	levels|compound|START_ENTITY levels|nmod|END_ENTITY	Mean serum AMH levels in normal adult men were low -LRB- 20 + / -4.9 pmol/L -RRB- .
16914173	0	AMN082	91,97	mGluR7	0,6	AMN082	mGluR7	MESH:C507346	14807(Tax:10090)	Chemical	Gene	activation|nmod|START_ENTITY undergoes|advcl|activation undergoes|nsubj|END_ENTITY	mGluR7 undergoes rapid internalization in response to activation by the allosteric agonist AMN082 .
18155073	0	AMN082	66,72	mGluR7	39,45	AMN082	mGluR7	MESH:C507346	14807(Tax:10090)	Chemical	Gene	accumbens|nummod|START_ENTITY agonist|dep|accumbens agonist|compound|END_ENTITY	The metabotropic glutamate receptor 7 -LRB- mGluR7 -RRB- allosteric agonist AMN082 modulates nucleus accumbens GABA and glutamate , but not dopamine , in rats .
18533198	0	AMN082	0,6	mGluR7	22,28	AMN082	mGluR7	MESH:C507346	14807(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	AMN082 , an allosteric mGluR7 agonist that inhibits afferent glutamatergic transmission in rat basolateral amygdala .
24399715	0	AMN082	124,130	mGluR7	20,26	AMN082	mGluR7	MESH:C507346	14807(Tax:10090)	Chemical	Gene	study|nmod|START_ENTITY Contribution|dep|study Contribution|nmod|receptor receptor|amod|END_ENTITY	Contribution of the mGluR7 receptor to antiparkinsonian-like effects in rats : a behavioral study with the selective agonist AMN082 .
16721371	0	AMN107	0,6	BCR-ABL	55,62	AMN107	BCR-ABL	MESH:C498826	25	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	AMN107 -LRB- nilotinib -RRB- : a novel and selective inhibitor of BCR-ABL .
17291840	0	AMN107	132,138	BCR-ABL	103,110	AMN107	BCR-ABL	MESH:C498826	25	Chemical	Gene	method|appos|START_ENTITY method|nmod|detection detection|nmod|quantification quantification|nmod|nilotinib nilotinib|amod|END_ENTITY	High-performance liquid chromatography method with ultraviolet detection for the quantification of the BCR-ABL inhibitor nilotinib -LRB- AMN107 -RRB- in plasma , urine , culture medium and cell preparations .
17303698	0	AMN107	92,98	BCR-ABL	18,25	AMN107	BCR-ABL	MESH:C498826	25	Chemical	Gene	conferring|nmod|START_ENTITY conferring|nsubj|Identification Identification|nmod|mutations mutations|amod|END_ENTITY	Identification of BCR-ABL point mutations conferring resistance to the Abl kinase inhibitor AMN107 -LRB- nilotinib -RRB- by a random mutagenesis study .
17715389	0	AMN107	20,26	BCR-ABL	48,55	AMN107	BCR-ABL	MESH:C498826	25	Chemical	Gene	Nilotinib|appos|START_ENTITY Nilotinib|appos|inhibitor inhibitor|amod|END_ENTITY	Nilotinib -LRB- formerly AMN107 -RRB- , a highly selective BCR-ABL tyrosine kinase inhibitor , is effective in patients with Philadelphia_chromosome-positive_chronic_myelogenous_leukemia in chronic phase following imatinib resistance and intolerance .
15930265	0	AMN107	40,46	Bcr-Abl	21,28	AMN107	Bcr-Abl	MESH:C498826	25	Chemical	Gene	mutants|nsubj|START_ENTITY mutants|nmod|activity activity|nmod|inhibitors inhibitors|amod|END_ENTITY	In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants .
16000593	0	AMN107	0,6	Bcr-Abl	45,52	AMN107	Bcr-Abl	MESH:C498826	25	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	AMN107 , a novel aminopyrimidine inhibitor of Bcr-Abl , has in vitro activity against imatinib-resistant chronic myeloid_leukemia .
16078266	0	AMN107	0,6	Bcr-Abl	50,57	AMN107	Bcr-Abl	MESH:C498826	25	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|activation activation|amod|END_ENTITY	AMN107 , a novel aminopyrimidine inhibitor of p190 Bcr-Abl activation and of in vitro proliferation of Philadelphia-positive acute_lymphoblastic_leukemia cells .
16614241	0	AMN107	157,163	Bcr-Abl	0,7	AMN107	Bcr-Abl	MESH:C498826	25	Chemical	Gene	nilotinib|appos|START_ENTITY associated|nmod|nilotinib predicts|xcomp|associated predicts|nsubj|screening screening|compound|END_ENTITY	Bcr-Abl resistance screening predicts a limited spectrum of point mutations to be associated with clinical resistance to the Abl kinase inhibitor nilotinib -LRB- AMN107 -RRB- .
16078266	0	AMN107	0,6	p190	45,49	AMN107	p190	MESH:C498826	8506	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|activation activation|amod|END_ENTITY	AMN107 , a novel aminopyrimidine inhibitor of p190 Bcr-Abl activation and of in vitro proliferation of Philadelphia-positive acute_lymphoblastic_leukemia cells .
19154087	0	AMN_082	0,7	mGluR7	23,29	AMN 082	mGluR7	MESH:C507346	14807(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonist agonist|nmod|END_ENTITY	AMN_082 , an agonist of mGluR7 , exhibits mixed anti- and proconvulsant effects in developing rats .
21416543	0	AMP	214,217	AMPK	12,16	AMP	AMPK	MESH:D000249	5563	Chemical	Gene	rise|nsubj|START_ENTITY activated|advcl|rise kinase|acl:relcl|activated I.|parataxis|kinase I.|nsubj|site site|compound|END_ENTITY	A preferred AMPK phosphorylation site adjacent to the inhibitory loop of cardiac and skeletal troponin I. 5 ' - AMP-activated protein kinase -LRB- AMPK -RRB- is a serine/threonine protein kinase that is activated when cellular AMP to ATP ratios rise , potentially serving as a key regulator of cellular energetics .
21769098	6	AMP	841,844	AMPK	774,778	AMP	AMPK	MESH:D000249	5563	Chemical	Gene	protect|nsubj|START_ENTITY mechanism|acl:relcl|protect provides|dobj|mechanism END_ENTITY|acl:relcl|provides	We also review recent progress in structural studies on phosphorylated AMPK that provides a mechanism for the regulation of AMPK in which AMP and ADP protect it against dephosphorylation .
24450630	0	AMP	54,57	AMPK	0,4	AMP	AMPK	MESH:D000249	5563	Chemical	Gene	regulated|nmod|START_ENTITY sensor|acl|regulated END_ENTITY|dep|sensor	AMPK : a cellular energy sensor primarily regulated by AMP .
25084564	0	AMP	83,86	AMPK	27,31	AMP	AMPK	MESH:D000249	5563	Chemical	Gene	ADP|compound|START_ENTITY increasing|dobj|ADP activates|advcl|increasing activates|dobj|END_ENTITY	Oxidative stress activates AMPK in cultured cells primarily by increasing cellular AMP and/or ADP .
26001218	2	AMP	268,271	AMPK	231,235	AMP	PIKE	D000667	116986	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	AMPK is mainly regulated by cellular AMP and phosphorylation by upstream kinases .
25921306	0	AMP	137,140	At3g01520	33,42	AMP	At3g01520	D000667	821122(Tax:3702)	Chemical	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Crystal structure of the protein At3g01520 , a eukaryotic universal stress protein-like protein from arabidopsis_thaliana in complex with AMP .
20351066	0	AMP	0,3	Bim	55,58	AMP	Bim	MESH:D000249	10018	Chemical	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	AMP kinase-mediated activation of the BH3-only protein Bim couples energy depletion to stress-induced apoptosis .
11040036	0	AMP	7,10	Cdc42	42,47	AMP	Cdc42	MESH:D000249	998	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|dobj|END_ENTITY	Cyclic AMP and protein kinase A stimulate Cdc42 : role of A -LRB- 2 -RRB- adenosine receptors in human mast cells .
12750405	0	AMP	7,10	GLUT4	0,5	AMP	GLUT4	MESH:D000249	20528(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY END_ENTITY|appos|kinase	GLUT4 , AMP kinase , but not the insulin_receptor , are required for hepatoportal glucose sensor-stimulated muscle glucose utilization .
24895169	0	AMP	0,3	PRKAA1	12,18	AMP	PRKAA1	MESH:D000249	5562	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	AMP kinase -LRB- PRKAA1 -RRB- .
25513285	1	AMP	19,22	PRKAA1	31,37	AMP	PRKAA1	MESH:D000249	5562	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	AMP kinase -LRB- PRKAA1 -RRB- .
19001547	0	AMP	14,17	Rho_kinase	43,53	AMP	Rho kinase	MESH:D000249	19878(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|nmod|END_ENTITY	Activation of AMP kinase and inhibition of Rho_kinase induce the mineralization of osteoblastic MC3T3-E1 cells through endothelial_NOS and BMP-2 expression .
6739737	0	AMP	77,80	adenine-phosphoribosyltransferase	32,65	AMP	adenine-phosphoribosyltransferase	MESH:D000249	11821(Tax:10090)	Chemical	Gene	pathway|nmod|START_ENTITY pathway|amod|END_ENTITY	-LSB- Postradiation disorders in the adenine-phosphoribosyltransferase pathway of AMP biosynthesis -RSB- .
15001573	0	AMP	75,78	cell-surface_receptor	41,62	AMP	cell-surface receptor	MESH:D000249	57126	Chemical	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification and characterization of a cell-surface_receptor , P2Y15 , for AMP and adenosine .
174074	0	AMP	43,46	nerve_growth_factor	14,33	AMP	nerve growth factor	MESH:D000249	310738(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|END_ENTITY	The effect of nerve_growth_factor on cycle AMP levels in superior cerival ganglia of the rat .
10467600	0	AMPA	58,62	BDNF	103,107	AMPA	BDNF	MESH:D018350	627	Chemical	Gene	receptors|compound|START_ENTITY desensitization|nmod|receptors inducing|dobj|desensitization paradigm|acl|inducing evokes|nsubj|paradigm evokes|dobj|increase increase|nmod|mRNA mRNA|compound|END_ENTITY	A stimulus paradigm inducing long-term desensitization of AMPA receptors evokes a specific increase in BDNF mRNA in cerebellar slices .
11406193	0	AMPA	77,81	BDNF	14,18	AMPA	BDNF	MESH:D018350	627	Chemical	Gene	potentiator|compound|START_ENTITY LY392098|appos|potentiator expression|nmod|LY392098 expression|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of BDNF expression in primary neuron culture by LY392098 , a novel AMPA receptor potentiator .
12213254	0	AMPA	3,7	BDNF	65,69	AMPA	BDNF	MESH:D018350	24225(Tax:10116)	Chemical	Gene	potentiator|compound|START_ENTITY modulates|nsubj|potentiator modulates|dobj|expression expression|nmod|END_ENTITY	An AMPA receptor potentiator modulates hippocampal expression of BDNF : an in vivo study .
15287886	0	AMPA	0,4	BDNF	180,184	AMPA	BDNF	MESH:D018350	627	Chemical	Gene	protects|nsubj|START_ENTITY protects|advcl|glutamate glutamate|xcomp|upregulate upregulate|dobj|expression expression|amod|END_ENTITY	AMPA protects cultured neurons against glutamate excitotoxicity through a phosphatidylinositol 3-kinase-dependent activation in extracellular signal-regulated kinase to upregulate BDNF gene expression .
19136940	0	AMPA	70,74	BDNF	52,56	AMPA	BDNF	MESH:D018350	12064(Tax:10090)	Chemical	Gene	S18986|compound|START_ENTITY S18986|amod|END_ENTITY	GAP-43 is essential for the neurotrophic effects of BDNF and positive AMPA receptor modulator S18986 .
19371576	0	AMPA	54,58	BDNF	0,4	AMPA	BDNF	MESH:D018350	627	Chemical	Gene	modulators|compound|START_ENTITY effects|nmod|modulators mediates|dobj|effects mediates|nsubj|END_ENTITY	BDNF mediates the neuroprotective effects of positive AMPA receptor modulators against MPP + - induced toxicity in cultured hippocampal and mesencephalic slices .
19587275	0	AMPA	9,13	BDNF	53,57	AMPA	BDNF	MESH:D018350	627	Chemical	Gene	modulation|compound|START_ENTITY stimulates|nsubj|modulation stimulates|dobj|release release|amod|END_ENTITY	Positive AMPA receptor modulation rapidly stimulates BDNF release and increases dendritic mRNA translation .
22079295	0	AMPA	4,8	BDNF	82,86	AMPA	BDNF	MESH:D018350	24225(Tax:10116)	Chemical	Gene	Org_26576|compound|START_ENTITY modulates|nsubj|Org_26576 modulates|dobj|transcription transcription|nmod|isoforms isoforms|amod|END_ENTITY	The AMPA receptor potentiator Org_26576 modulates stress-induced transcription of BDNF isoforms in rat hippocampus .
23460828	0	AMPA	102,106	BDNF	6,10	AMPA	BDNF	MESH:D018350	627	Chemical	Gene	expression|compound|START_ENTITY implications|nmod|expression upregulates|dep|implications upregulates|compound|END_ENTITY	Acute BDNF treatment upregulates GluR1-SAP97 and GluR2-GRIP1 interactions : implications for sustained AMPA receptor expression .
23732839	0	AMPA	26,30	BDNF	77,81	AMPA	BDNF	MESH:D018350	24225(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|role role|nmod|END_ENTITY	Antidepressant effects of AMPA and ketamine combination : role of hippocampal BDNF , synapsin , and mTOR .
24712995	0	AMPA	62,66	BDNF	0,4	AMPA	BDNF	MESH:D018350	24225(Tax:10116)	Chemical	Gene	expression|compound|START_ENTITY alterations|nmod|expression medium|nmod|alterations neurons|amod|medium contributes|dobj|neurons contributes|nsubj|END_ENTITY	BDNF contributes to both rapid and homeostatic alterations in AMPA receptor surface expression in nucleus accumbens medium spiny neurons .
17482902	0	AMPA	44,48	Brain-derived_neurotrophic_factor	0,33	AMPA	Brain-derived neurotrophic factor	MESH:D018350	627	Chemical	Gene	trafficking|compound|START_ENTITY regulates|dobj|trafficking regulates|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor regulates AMPA receptor trafficking to post-synaptic densities via IP3R and TRPC calcium signaling .
21692887	0	AMPA	52,56	Brain-derived_neurotrophic_factor	0,33	AMPA	Brain-derived neurotrophic factor	MESH:D018350	24225(Tax:10116)	Chemical	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor rapidly increases AMPA receptor surface expression in rat nucleus accumbens .
11740502	0	AMPA	54,58	CA1	82,85	AMPA	CA1	MESH:D018350	310218(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|nmod|END_ENTITY	LTP leads to rapid surface expression of NMDA but not AMPA receptors in adult rat CA1 .
15158178	0	AMPA	84,88	CA1	115,118	AMPA	CA1	MESH:D018350	12346(Tax:10090)	Chemical	Gene	responses|compound|START_ENTITY responses|nmod|region region|compound|END_ENTITY	Interleukin-18 stimulates synaptically released glutamate and enhances postsynaptic AMPA receptor responses in the CA1 region of mouse hippocampal slices .
9849675	0	AMPA	55,59	CA1	115,118	AMPA	CA1	MESH:D018350	759	Chemical	Gene	transmission|compound|START_ENTITY transmission|nmod|END_ENTITY	An investigation of the expression mechanism of LTP of AMPA receptor-mediated synaptic transmission at hippocampal CA1 synapses using failures analysis and dendritic recordings .
10934277	0	AMPA	0,4	CREB	42,46	AMPA	CREB	MESH:D018350	1385	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	AMPA receptor-mediated , calcium-dependent CREB phosphorylation in a subpopulation of auditory neurons surviving activity deprivation .
26863325	0	AMPA	39,43	CaMKII	29,35	AMPA	CaMKII	MESH:D018350	818	Chemical	Gene	Trafficking|compound|START_ENTITY END_ENTITY|nmod|Trafficking	Long-Term Potentiation : From CaMKII to AMPA Receptor Trafficking .
25547714	0	AMPA	6,10	GLUA1	11,16	AMPA	GLUA1	MESH:D018350	14799(Tax:10090)	Chemical	Gene	Subunit|compound|START_ENTITY Subunit|compound|END_ENTITY	Adult AMPA GLUA1 Receptor Subunit Loss in 5-HT Neurons Results in a Specific Anxiety-Phenotype with Evidence for Dysregulation of 5-HT Neuronal Activity .
17545169	0	AMPA	72,76	GLUR1	60,65	AMPA	GLUR1	MESH:D018350	2890	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Receptor occupancy and channel-opening kinetics : a study of GLUR1 L497Y AMPA receptor .
18977416	0	AMPA	21,25	GLUR2	4,9	AMPA	GLUR2	MESH:D018350	2891	Chemical	Gene	receptors|compound|START_ENTITY subunit|nmod|receptors subunit|compound|END_ENTITY	The GLUR2 subunit of AMPA receptors : synaptic role .
16262247	0	AMPA	31,35	GMP	14,17	AMPA	GMP	MESH:D018350	22978	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	Binding of 5 ' - GMP to the GluR2 AMPA receptor : insight from targeted_molecular_dynamics simulations .
25224260	1	AMPA	113,117	GRIA1	99,104	AMPA	GRIA1	MESH:D018350	14799(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	A role for impaired short-term habituation and the GRIA1 -LRB- GluA1 -RRB- AMPA receptor subunit .
19470654	0	AMPA	67,71	GluA1	61,66	AMPA	GluA1	MESH:D018350	14799(Tax:10090)	Chemical	Gene	mice|compound|START_ENTITY mice|amod|END_ENTITY	Enhanced long-term and impaired short-term spatial memory in GluA1 AMPA receptor subunit knockout mice : evidence for a dual-process memory model .
19664265	0	AMPA	13,17	GluA1	35,40	AMPA	GluA1	MESH:D018350	14799(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY Roles|nmod|receptor subunit|nsubj|Roles subunit|dobj|END_ENTITY	Roles of the AMPA receptor subunit GluA1 but not GluA2 in synaptic potentiation and activation of ERK in the anterior_cingulate_cortex .
19906877	0	AMPA	18,22	GluA1	47,52	AMPA	GluA1	MESH:D018350	14799(Tax:10090)	Chemical	Gene	GluR1|compound|START_ENTITY roles|nmod|GluR1 roles|appos|END_ENTITY	Specific roles of AMPA receptor subunit GluR1 -LRB- GluA1 -RRB- phosphorylation sites in regulating synaptic plasticity in the CA1 region of hippocampus .
20350557	0	AMPA	41,45	GluA1	35,40	AMPA	GluA1	MESH:D018350	14799(Tax:10090)	Chemical	Gene	mice|compound|START_ENTITY mice|amod|END_ENTITY	Spatial working memory_deficits in GluA1 AMPA receptor subunit knockout mice reflect impaired short-term habituation : evidence for Wagner 's dual-process memory model .
21125585	0	AMPA	99,103	GluA1	93,98	AMPA	GluA1	MESH:D018350	14799(Tax:10090)	Chemical	Gene	mice|compound|START_ENTITY mice|amod|END_ENTITY	The role of habituation in hippocampus-dependent spatial working memory tasks : evidence from GluA1 AMPA receptor subunit knockout mice .
21135237	0	AMPA	22,26	GluA1	102,107	AMPA	GluA1	MESH:D018350	2890	Chemical	Gene	receptors|compound|START_ENTITY targeting|nmod|receptors regulated|nsubjpass|targeting regulated|nmod|loop loop|nmod|END_ENTITY	Synaptic targeting of AMPA receptors is regulated by a CaMKII site in the first intracellular loop of GluA1 .
21148011	0	AMPA	63,67	GluA1	37,42	AMPA	GluA1	MESH:D018350	2890	Chemical	Gene	endocytosis|compound|START_ENTITY mediates|dobj|endocytosis mediates|nsubj|ubiquitination ubiquitination|nmod|END_ENTITY	Activity-dependent ubiquitination of GluA1 mediates a distinct AMPA receptor endocytosis and sorting pathway .
21156788	0	AMPA	103,107	GluA1	97,102	AMPA	GluA1	MESH:D018350	2890	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Ca2 + / calmodulin-dependent protein kinase II inhibitors disrupt AKAP79-dependent PKC signaling to GluA1 AMPA receptors .
21307330	0	AMPA	0,4	GluA1	29,34	AMPA	GluA1	MESH:D018350	14799(Tax:10090)	Chemical	Gene	GluR1|compound|START_ENTITY GluR1|appos|END_ENTITY	AMPA receptor subunit GluR1 -LRB- GluA1 -RRB- serine-845 site is involved in synaptic depression but not in spine shrinkage associated with chemical long-term depression .
21325433	0	AMPA	22,26	GluA1	16,21	AMPA	GluA1	MESH:D018350	14799(Tax:10090)	Chemical	Gene	subunit|compound|START_ENTITY subunit|amod|END_ENTITY	Deletion of the GluA1 AMPA receptor subunit alters the expression of short-term memory .
21378100	0	AMPA	22,26	GluA1	16,21	AMPA	GluA1	MESH:D018350	14799(Tax:10090)	Chemical	Gene	subunit|compound|START_ENTITY subunit|amod|END_ENTITY	Deletion of the GluA1 AMPA receptor subunit impairs recency-dependent object recognition memory .
21498562	0	AMPA	135,139	GluA1	43,48	AMPA	GluA1	MESH:D018350	50592(Tax:10116)	Chemical	Gene	hypothesis|compound|START_ENTITY testing|dobj|hypothesis modify|parataxis|testing modify|dobj|phosphorylation phosphorylation|amod|END_ENTITY	Odor preference learning and memory modify GluA1 phosphorylation and GluA1 distribution in the neonate rat olfactory bulb : testing the AMPA receptor hypothesis in an appetitive learning model .
21536866	0	AMPA	79,83	GluA1	73,78	AMPA	GluA1	MESH:D018350	14799(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Enhanced synaptic plasticity in mice with phosphomimetic mutation of the GluA1 AMPA receptor .
21641937	0	AMPA	48,52	GluA1	42,47	AMPA	GluA1	MESH:D018350	14799(Tax:10090)	Chemical	Gene	mice|compound|START_ENTITY mice|amod|END_ENTITY	Dissociations within short-term memory in GluA1 AMPA receptor subunit knockout mice .
22722203	0	AMPA	79,83	GluA1	73,78	AMPA	GluA1	MESH:D018350	14799(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors .
23117296	0	AMPA	20,24	GluA1	14,19	AMPA	GluA1	MESH:D018350	50592(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Regulation of GluA1 AMPA receptor through PKC phosphorylation induced by free fatty_acid derivative HUHS2002 .
23504989	0	AMPA	79,83	GluA1	93,98	AMPA	GluA1	MESH:D018350	14799(Tax:10090)	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	CREB is necessary for synaptic maintenance and learning-induced changes of the AMPA receptor GluA1 subunit .
23747591	0	AMPA	66,70	GluA1	60,65	AMPA	GluA1	MESH:D018350	50592(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Regulation of phosphorylation of synaptic and extrasynaptic GluA1 AMPA receptors in the rat forebrain by amphetamine .
24133208	0	AMPA	15,19	GluA1	120,125	AMPA	GluA1	MESH:D018350	2890	Chemical	Gene	START_ENTITY|acl:relcl|regulate regulate|dobj|trafficking trafficking|amod|END_ENTITY	Ca2 + - permeable AMPA -LRB- a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid -RRB- receptors and dopamine D1 receptors regulate GluA1 trafficking in striatal neurons .
24339333	0	AMPA	51,55	GluA1	45,50	AMPA	GluA1	MESH:D018350	14799(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Phenotype of mice with inducible ablation of GluA1 AMPA receptors during late adolescence : relevance for mental_disorders .
24567325	0	AMPA	60,64	GluA1	32,37	AMPA	GluA1	MESH:D018350	2890	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Sequential delivery of synaptic GluA1 - and GluA4-containing AMPA receptors -LRB- AMPARs -RRB- by SAP97 anchored protein complexes in classical conditioning .
24738995	0	AMPA	37,41	GluA1	31,36	AMPA	GluA1	MESH:D018350	2890	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Mechanism of inhibition of the GluA1 AMPA receptor channel opening by the 2,3-benzodiazepine compound GYKI_52466 and a N-methyl-carbamoyl derivative .
24895223	0	AMPA	27,31	GluA1	21,26	AMPA	GluA1	MESH:D018350	14799(Tax:10090)	Chemical	Gene	ablation|compound|START_ENTITY ablation|compound|END_ENTITY	Impact of adolescent GluA1 AMPA receptor ablation in forebrain excitatory neurons on behavioural correlates of mood_disorders .
24907515	0	AMPA	34,38	GluA1	28,33	AMPA	GluA1	MESH:D018350	14799(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Propofol selectively alters GluA1 AMPA receptor phosphorylation in the hippocampus but not prefrontal cortex in young and aged mice .
24942137	0	AMPA	30,34	GluA1	24,29	AMPA	GluA1	MESH:D018350	2890	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Phosphorylation of S845 GluA1 AMPA receptors modulates spatial memory and structural plasticity in the ventral striatum .
25224260	1	AMPA	113,117	GluA1	106,111	AMPA	GluA1	MESH:D018350	14799(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	A role for impaired short-term habituation and the GRIA1 -LRB- GluA1 -RRB- AMPA receptor subunit .
25381005	0	AMPA	23,27	GluA1	37,42	AMPA	GluA1	MESH:D018350	14799(Tax:10090)	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	Phosphorylation of the AMPA receptor GluA1 subunit regulates memory load capacity .
25500815	0	AMPA	159,163	GluA1	98,103	AMPA	GluA1	MESH:D018350	14799(Tax:10090)	Chemical	Gene	Receptor|appos|START_ENTITY Receptor|amod|a-Amino-3-Hydroxy-5-Methyl-4-Isoxazole a-Amino-3-Hydroxy-5-Methyl-4-Isoxazole|advmod|END_ENTITY	Low-Density_Lipoprotein_Receptor-Related_Protein_1 -LRB- LRP1 -RRB- Regulates the Stability and Function of GluA1 a-Amino-3-Hydroxy-5-Methyl-4-Isoxazole Propionic_Acid -LRB- AMPA -RRB- Receptor in Neurons .
25660027	0	AMPA	63,67	GluA1	37,42	AMPA	GluA1	MESH:D018350	2890	Chemical	Gene	Sorting|compound|START_ENTITY Regulates|dobj|Sorting Regulates|nsubj|Ubiquitination Ubiquitination|nmod|END_ENTITY	Activity-Dependent Ubiquitination of GluA1 and GluA2 Regulates AMPA Receptor Intracellular Sorting and Degradation .
26055072	0	AMPA	73,77	GluA1	56,61	AMPA	GluA1	MESH:D018350	2890	Chemical	Gene	receptor|compound|START_ENTITY subunit|nmod|receptor subunit|amod|END_ENTITY	Intracellular oligomeric amyloid-beta rapidly regulates GluA1 subunit of AMPA receptor in the hippocampus .
26338711	0	AMPA	37,41	GluA1	59,64	AMPA	GluA1	MESH:D018350	14799(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY synthesis|nmod|receptor regulation|nmod|synthesis subunit|nsubj|regulation subunit|dobj|END_ENTITY	Novel regulation of the synthesis of AMPA receptor subunit GluA1 by carnitine_palmitoyltransferase_1C -LRB- CPT1C -RRB- in the hippocampus .
26718600	4	AMPA	675,679	GluA1	691,696	AMPA	GluN1	MESH:D018350	2902	Chemical	Gene	receptors|compound|START_ENTITY receptors|dep|END_ENTITY	Nine subunits of iGluRs were analyzed using in situ hybridization as follows : AMPA receptors -LRB- GluA1 , GluA2 , GluA3 , and GluA4 -RRB- , kainate receptors -LRB- GluK1 , GluK2 , and GluK4 -RRB- , and NMDA receptors -LRB- GluN1 and GluN2A -RRB- .
26773257	0	AMPA	86,90	GluA1	58,63	AMPA	GluA1	MESH:D018350	50592(Tax:10116)	Chemical	Gene	mediated-neurotransmission|compound|START_ENTITY facilitate|dobj|mediated-neurotransmission signal|xcomp|facilitate signal|dobj|phosphorylation phosphorylation|nmod|subunit subunit|amod|END_ENTITY	Hippocampal 5-HT7 receptors signal phosphorylation of the GluA1 subunit to facilitate AMPA receptor mediated-neurotransmission in vitro and in vivo .
20199107	0	AMPA	71,75	GluA2	121,126	AMPA	GluA2	MESH:D018350	2891	Chemical	Gene	modulator|compound|START_ENTITY selectivity|nmod|modulator mechanism|nmod|selectivity mechanism|dep|structures structures|nmod|END_ENTITY	Molecular mechanism of flop selectivity and subsite recognition for an AMPA receptor allosteric modulator : structures of GluA2 and GluA3 in complexes with PEPA .
20534470	0	AMPA	33,37	GluA2	47,52	AMPA	GluA2	MESH:D018350	2891	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	Plasma membrane insertion of the AMPA receptor GluA2 subunit is regulated by NSF binding and Q/R editing of the ion pore .
20980546	0	AMPA	25,29	GluA2	95,100	AMPA	GluA2	MESH:D018350	14800(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY Potentiation|nmod|receptors requires|nsubj|Potentiation requires|dobj|subunit subunit|amod|END_ENTITY	Potentiation of synaptic AMPA receptors induced by the deletion of NMDA receptors requires the GluA2 subunit .
21414928	0	AMPA	41,45	GluA2	63,68	AMPA	GluA2	MESH:D018350	2891	Chemical	Gene	receptor|compound|START_ENTITY ubiquitination|nmod|receptor subunit|nsubj|ubiquitination subunit|dobj|END_ENTITY	Activity-dependent ubiquitination of the AMPA receptor subunit GluA2 .
21419184	0	AMPA	16,20	GluA2	37,42	AMPA	GluA2	MESH:D018350	2891	Chemical	Gene	subunits|compound|START_ENTITY subunits|appos|END_ENTITY	Upregulation of AMPA receptor GluR2 -LRB- GluA2 -RRB- subunits in subcortical_ischemic_vascular_dementia is repressed in the presence of Alzheimer 's _ disease .
21751782	0	AMPA	37,41	GluA2	31,36	AMPA	GluA2	MESH:D018350	2891	Chemical	Gene	opening|compound|START_ENTITY opening|amod|END_ENTITY	Mechanism of inhibition of the GluA2 AMPA receptor channel opening : consequences of adding an N-3_methylcarbamoyl group to the diazepine ring of 2,3-benzodiazepine derivatives .
22059113	0	AMPA	37,41	GluA2	31,36	AMPA	GluA2	MESH:D018350	2891	Chemical	Gene	Opening|compound|START_ENTITY Opening|compound|END_ENTITY	Mechanism of Inhibition of the GluA2 AMPA Receptor Channel Opening : the Role of 4-Methyl versus 4-Carbonyl Group on the Diazepine Ring of 2,3-Benzodiazepine Derivatives .
22232691	0	AMPA	42,46	GluA2	36,41	AMPA	GluA2	MESH:D018350	14800(Tax:10090)	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	b3 integrin interacts directly with GluA2 AMPA receptor subunit and regulates AMPA receptor expression in hippocampal neurons .
22304561	0	AMPA	33,37	GluA2	27,32	AMPA	GluA2	MESH:D018350	2891	Chemical	Gene	opening|compound|START_ENTITY opening|amod|END_ENTITY	Mechanism of inhibition of GluA2 AMPA receptor channel opening by 2,3-benzodiazepine derivatives : functional consequences of replacing a 7,8-methylenedioxy with a 7,8-ethylenedioxy moiety .
23076153	0	AMPA	135,139	GluA2	161,166	AMPA	GluA2	MESH:D018350	2891	Chemical	Gene	a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic_acid|appos|START_ENTITY a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic_acid|dep|receptor receptor|appos|END_ENTITY	The structure of -LRB- - -RRB- - kaitocephalin bound to the ligand binding domain of the -LRB- S -RRB- - a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic_acid -LRB- AMPA -RRB- / glutamate receptor , GluA2 .
23402301	0	AMPA	37,41	GluA2	31,36	AMPA	GluA2	MESH:D018350	2891	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Mechanism of inhibition of the GluA2 AMPA receptor channel opening by talampanel and its enantiomer : the stereochemistry of the 4-methyl group on the diazepine ring of 2,3-benzodiazepine derivatives .
23999288	0	AMPA	36,40	GluA2	100,105	AMPA	GluA2	MESH:D018350	2891	Chemical	Gene	receptor|compound|START_ENTITY analysis|nmod|receptor modulators|nsubj|analysis modulators|nmod|domain domain|amod|END_ENTITY	Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain .
24434560	0	AMPA	52,56	GluA2	28,33	AMPA	GluA2	MESH:D018350	2891	Chemical	Gene	receptor|compound|START_ENTITY reporter|nmod|receptor END_ENTITY|nmod|reporter	Validity of pHluorin-tagged GluA2 as a reporter for AMPA receptor surface expression and endocytosis .
25031403	0	AMPA	135,139	GluA2	262,267	AMPA	GluA2	MESH:D018350	29627(Tax:10116)	Chemical	Gene	endocytosis|compound|START_ENTITY facilitates|dobj|endocytosis facilitates|parataxis|subunits subunits|nsubj|regulation regulation|nmod|END_ENTITY	Prolonged adenosine A1 receptor activation in hypoxia and pial_vessel_disruption focal cortical ischemia facilitates clathrin-mediated AMPA receptor endocytosis and long-lasting synaptic inhibition in rat hippocampal CA3-CA1 synapses : differential regulation of GluA2 and GluA1 subunits by p38 MAPK and JNK .
25475532	0	AMPA	122,126	GluA2	116,121	AMPA	GluA2	MESH:D018350	29627(Tax:10116)	Chemical	Gene	subunit|compound|START_ENTITY subunit|amod|END_ENTITY	Identification of NADPH oxidase as a key mediator in the post-ischemia-induced sequestration and degradation of the GluA2 AMPA receptor subunit .
26488171	0	AMPA	96,100	GluA2	90,95	AMPA	GluA2	MESH:D018350	2891	Chemical	Gene	Subunits|compound|START_ENTITY Subunits|compound|END_ENTITY	Postsynaptic VAMP/Synaptobrevin Facilitates Differential Vesicle Trafficking of GluA1 and GluA2 AMPA Receptor Subunits .
24599589	0	AMPA	122,126	GluA4	97,102	AMPA	GluA4	MESH:D018350	14802(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Developmental switch in the kinase dependency of long-term potentiation depends on expression of GluA4 subunit-containing AMPA receptors .
26961102	0	AMPA	17,21	GluA4	0,5	AMPA	GluA4	MESH:D018350	14802(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY subunit|nmod|receptors subunit|amod|END_ENTITY	GluA4 subunit of AMPA receptors mediates the early synaptic response to altered network activity in the developing hippocampus .
26041915	0	AMPA	42,46	GluN2B-Containing_NMDA_Receptors	0,32	AMPA	GluN2B-Containing NMDA Receptors	MESH:D018350	14812(Tax:10090)	Chemical	Gene	Traffic|compound|START_ENTITY Traffic|compound|END_ENTITY	GluN2B-Containing_NMDA_Receptors Regulate AMPA Receptor Traffic through Anchoring of the Synaptic Proteasome .
18085873	0	AMPA	32,36	GluR-1	25,31	AMPA	GluR-1	MESH:D018350	14799(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Targeted deletion of the GluR-1 AMPA receptor in mice dissociates general and outcome-specific influences of appetitive rewards on learning .
15541312	0	AMPA	4,8	GluR-A	27,33	AMPA	GluR-A	MESH:D018350	14799(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY subunits|nsubj|receptor subunits|ccomp|modulate modulate|nsubj|END_ENTITY	The AMPA receptor subunits GluR-A and GluR-B reciprocally modulate spinal synaptic plasticity and inflammatory_pain .
16326431	0	AMPA	78,82	GluR-A	161,167	AMPA	GluR-A	MESH:D018350	50592(Tax:10116)	Chemical	Gene	receptor|appos|START_ENTITY expression|nsubj|receptor expression|nmod|subunits subunits|appos|END_ENTITY	Increases in -LSB- -LRB- 3 -RRB- H -RSB- - alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic_acid -LRB- AMPA -RRB- receptor binding and mRNA expression of AMPA-sensitive glutamate_receptor_A -LRB- GluR-A -RRB- subunits in rats withdrawn from butorphanol .
17592947	0	AMPA	42,46	GluR-A	34,40	AMPA	GluR-A	MESH:D018350	14799(Tax:10090)	Chemical	Gene	subunits|amod|START_ENTITY subunits|appos|END_ENTITY	Deletion of glutamate_receptor-A -LRB- GluR-A -RRB- AMPA receptor subunits impairs one-trial spatial memory .
18394473	0	AMPA	31,35	GluR-A	16,22	AMPA	GluR-A	MESH:D018350	14799(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	The role of the GluR-A -LRB- GluR1 -RRB- AMPA receptor subunit in learning and memory .
18492725	0	AMPA	0,4	GluR-A	25,31	AMPA	GluR-A	MESH:D018350	14799(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY subunit|nsubj|receptor subunit|dobj|1 1|appos|END_ENTITY	AMPA receptor subunit 1 -LRB- GluR-A -RRB- knockout mice model the glutamate hypothesis of depression .
20572199	0	AMPA	0,4	GluR-A	5,11	AMPA	GluR-A	MESH:D018350	14799(Tax:10090)	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	AMPA GluR-A receptor subunit mediates hippocampal responsiveness in mice exposed to stress .
2176160	0	AMPA	117,121	GluR-A	80,86	AMPA	GluR-A	MESH:D018350	50592(Tax:10116)	Chemical	Gene	sites|compound|START_ENTITY subpopulation|nmod|sites recognize|dobj|subpopulation recognize|nsubj|Antibodies Antibodies|nmod|peptide peptide|nmod|subunit subunit|appos|END_ENTITY	Antibodies to a C-terminal peptide of the rat brain glutamate receptor subunit , GluR-A , recognize a subpopulation of AMPA binding sites but not kainate sites .
14687553	0	AMPA	73,77	GluR-B	49,55	AMPA	GluR-B	MESH:D018350	2891	Chemical	Gene	receptors|compound|START_ENTITY containing|dobj|receptors plasticity|parataxis|containing plasticity|dobj|delivery delivery|nmod|END_ENTITY	Glutamatergic plasticity by synaptic delivery of GluR-B -LRB- long -RRB- - containing AMPA receptors .
16099814	0	AMPA	60,64	GluR-B	42,48	AMPA	GluR-B	MESH:D018350	14800(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Impaired reproductive behavior by lack of GluR-B containing AMPA receptors but not of NMDA receptors in hypothalamic and septal neurons .
8269514	0	AMPA	15,19	GluR-B	37,43	AMPA	GluR-B	MESH:D018350	29627(Tax:10116)	Chemical	Gene	subunit|compound|START_ENTITY editing|nmod|subunit END_ENTITY|nsubj|editing	RNA editing of AMPA receptor subunit GluR-B : a base-paired intron-exon structure determines position and efficiency .
8309523	0	AMPA	26,30	GluR-B	19,25	AMPA	GluR-B	MESH:D018350	2891	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Alterations of the GluR-B AMPA receptor subunit flip/flop expression in kainate-induced epilepsy and ischemia .
9347614	0	AMPA	48,52	GluR-B	11,17	AMPA	GluR-B	MESH:D018350	2891	Chemical	Gene	receptors|nummod|START_ENTITY +|dep|receptors +|nsubj|GluR2 GluR2|appos|END_ENTITY	The GluR2 -LRB- GluR-B -RRB- hypothesis : Ca -LRB- 2 + -RRB- - permeable AMPA receptors in neurological_disorders .
12574408	0	AMPA	29,33	GluR-D	22,28	AMPA	GluR-D	MESH:D018350	2893	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Surface expression of GluR-D AMPA receptor is dependent on an interaction between its C-terminal domain and a 4.1 protein .
19560629	0	AMPA	56,60	GluR-D	49,55	AMPA	GluR-D	MESH:D018350	2893	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Ethanol increases desensitization of recombinant GluR-D AMPA receptor and TARP combinations .
10627585	0	AMPA	17,21	GluR1	11,16	AMPA	GluR1	MESH:D018350	2890	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Control of GluR1 AMPA receptor function by cAMP-dependent protein kinase .
10731148	0	AMPA	8,12	GluR1	72,77	AMPA	GluR1	MESH:D018350	50592(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|dep|requirement requirement|nmod|END_ENTITY	Driving AMPA receptors into synapses by LTP and CaMKII : requirement for GluR1 and PDZ domain interaction .
10807936	0	AMPA	46,50	GluR1	68,73	AMPA	GluR1	MESH:D018350	2890	Chemical	Gene	receptor|compound|START_ENTITY terminus|nmod|receptor Involvement|nmod|terminus subunit|nsubj|Involvement subunit|dobj|END_ENTITY	Involvement of the proximal C terminus of the AMPA receptor subunit GluR1 in dendritic sorting .
10844017	0	AMPA	43,47	GluR1	37,42	AMPA	GluR1	MESH:D018350	14799(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Regulation of phosphorylation of the GluR1 AMPA receptor in the neostriatum by dopamine and psychostimulants in vivo .
12488532	3	AMPA	789,793	GluR1	812,817	AMPA	GluR5	MESH:D018350	100301967(Tax:8355)	Chemical	Gene	subtype|compound|START_ENTITY subtype|appos|END_ENTITY	Through mutagenesis studies of GluR5 and the AMPA receptor subtype , GluR1 , we demonstrate that this pronounced selectivity for ATPA can be ascribed to Ser741 in GluR5 and Met722 in GluR1 .
12628184	0	AMPA	23,27	GluR1	37,42	AMPA	GluR1	MESH:D018350	14799(Tax:10090)	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory .
12871650	0	AMPA	38,42	GluR1	61,66	AMPA	GluR1	MESH:D018350	14799(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY alcohol|nmod|receptor effects|nmod|alcohol subunit|nsubj|effects subunit|dobj|mice mice|appos|END_ENTITY	Neurobehavioral effects of alcohol in AMPA receptor subunit -LRB- GluR1 -RRB- deficient mice .
12871650	9	AMPA	1670,1674	GluR1	1622,1627	AMPA	GluR1	MESH:D018350	14799(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY role|nmod|receptors indicates|dobj|role indicates|nsubj|loss loss|nmod|effect effect|nmod|ethanol ethanol|nmod|mice mice|amod|END_ENTITY	In summary , although the loss of a hypothermic effect of ethanol in GluR1 - / - mice indicates a critical role for the AMPA receptors in this effect , the GluR1 subunit of the AMPA receptor does not seem to play a critical role in the etiology of alcohol_dependence .
12871650	9	AMPA	1726,1730	GluR1	1622,1627	AMPA	GluR1	MESH:D018350	14799(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY subunit|nmod|receptor seem|nsubj|subunit seem|advcl|indicates indicates|nsubj|loss loss|nmod|effect effect|nmod|ethanol ethanol|nmod|mice mice|amod|END_ENTITY	In summary , although the loss of a hypothermic effect of ethanol in GluR1 - / - mice indicates a critical role for the AMPA receptors in this effect , the GluR1 subunit of the AMPA receptor does not seem to play a critical role in the etiology of alcohol_dependence .
14559367	0	AMPA	69,73	GluR1	52,57	AMPA	GluR1	MESH:D018350	50592(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY subunit|nmod|receptors subunit|amod|END_ENTITY	Protein kinases regulate the phosphorylation of the GluR1 subunit of AMPA receptors of spinal cord in rats following noxious stimulation .
14678750	0	AMPA	65,69	GluR1	88,93	AMPA	GluR1	MESH:D018350	50592(Tax:10116)	Chemical	Gene	subunits|compound|START_ENTITY expression|nmod|subunits concomitant|nmod|expression END_ENTITY|amod|concomitant	AGS-induced expression of Narp is concomitant with expression of AMPA receptor subunits GluR1 and GluR2 in hippocampus but not inferior_colliculus of P77PMC rats .
15531103	0	AMPA	97,101	GluR1	91,96	AMPA	GluR1	MESH:D018350	2890	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	Activation of metabotropic glutamate receptors does not alter the phosphorylation state of GluR1 AMPA receptor subunit at serine 845 in perirhinal cortical neurons .
16037950	0	AMPA	10,14	GluR1	15,20	AMPA	GluR1	MESH:D018350	50592(Tax:10116)	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	Increased AMPA GluR1 receptor subunit labeling on the plasma membrane of dendrites in the basolateral amygdala of rats self-administering morphine .
16272153	0	AMPA	88,92	GluR1	48,53	AMPA	GluR1	MESH:D018350	2890	Chemical	Gene	receptors|compound|START_ENTITY primes|dobj|receptors primes|nsubj|trafficking trafficking|acl|regulated regulated|nmod|phosphorylation phosphorylation|amod|END_ENTITY	Extrasynaptic membrane trafficking regulated by GluR1 serine 845 phosphorylation primes AMPA receptors for long-term potentiation .
16336634	0	AMPA	43,47	GluR1	37,42	AMPA	GluR1	MESH:D018350	14799(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Regulation of phosphorylation of the GluR1 AMPA receptor by dopamine_D2_receptors .
16846856	0	AMPA	26,30	GluR1	99,104	AMPA	GluR1	MESH:D018350	2890	Chemical	Gene	receptors|compound|START_ENTITY incorporation|nmod|receptors controlled|nsubjpass|incorporation controlled|nmod|site site|nmod|END_ENTITY	Synaptic incorporation of AMPA receptors during LTP is controlled by a PKC phosphorylation site on GluR1 .
17251688	0	AMPA	110,114	GluR1	133,138	AMPA	GluR1	MESH:D018350	50592(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY variants|nmod|receptor expression|nmod|variants changes|nmod|expression Comparison|nmod|changes subtypes|nsubj|Comparison subtypes|dobj|END_ENTITY	Comparison of single - and repeated-ischemia-induced changes in expression of flip and flop splice variants of AMPA receptor subtypes GluR1 and GluR2 in the rats hippocampus CA1 subregion .
17335044	0	AMPA	52,56	GluR1	46,51	AMPA	GluR1	MESH:D018350	50592(Tax:10116)	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	Differential neuronal and glial expression of GluR1 AMPA receptor subunit and the scaffolding proteins SAP97 and 4.1 N during rat cerebellar development .
17360685	4	AMPA	838,842	GluR1	799,804	AMPA	GluR1	MESH:D018350	2890	Chemical	Gene	internalization|compound|START_ENTITY serine|dobj|internalization serine|nsubj|dephosphorylation dephosphorylation|nmod|END_ENTITY	Furthermore , dephosphorylation of GluR1 serine 845 triggers NMDA-induced AMPA receptor internalization .
17428797	0	AMPA	77,81	GluR1	29,34	AMPA	GluR1	MESH:D018350	2890	Chemical	Gene	receptors|compound|START_ENTITY susceptibility|nmod|receptors determines|dobj|susceptibility determines|nsubj|state state|nmod|subunits subunits|amod|END_ENTITY	The phosphorylation state of GluR1 subunits determines the susceptibility of AMPA receptors to calpain_cleavage .
17684498	0	AMPA	17,21	GluR1	22,27	AMPA	GluR1	MESH:D018350	14799(Tax:10090)	Chemical	Gene	striatal|compound|START_ENTITY striatal|compound|END_ENTITY	Mice lacking the AMPA GluR1 receptor exhibit striatal hyperdopaminergia and ` schizophrenia-related ' behaviors .
17689977	0	AMPA	92,96	GluR1	75,80	AMPA	GluR1	MESH:D018350	14799(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY subunit|nmod|receptors subunit|amod|END_ENTITY	Identification and characterization of a novel phosphorylation site on the GluR1 subunit of AMPA receptors .
18000827	0	AMPA	50,54	GluR1	73,78	AMPA	GluR1	MESH:D018350	2890	Chemical	Gene	receptor|compound|START_ENTITY complexity|nmod|receptor regulation|nmod|complexity subunits|nsubj|regulation subunits|dobj|END_ENTITY	Differential regulation of dendrite complexity by AMPA receptor subunits GluR1 and GluR2 in motor neurons .
18031714	0	AMPA	48,52	GluR1	71,76	AMPA	GluR1	MESH:D018350	50592(Tax:10116)	Chemical	Gene	subunit|compound|START_ENTITY subunit|appos|END_ENTITY	Sustained hypertension increases the density of AMPA receptor subunit , GluR1 , in baroreceptive regions of the nucleus tractus solitarii of the rat .
18198214	0	AMPA	127,131	GluR1	132,137	AMPA	GluR1	MESH:D018350	14799(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Interferon-gamma directly induces neurotoxicity through a neuron specific , calcium-permeable complex of IFN-gamma receptor and AMPA GluR1 receptor .
18239782	0	AMPA	77,81	GluR1	71,76	AMPA	GluR1	MESH:D018350	50592(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Combined blockade of alpha3beta4 nicotinic acetylcholine receptors and GluR1 AMPA receptors in rats prevents kainate-induced tonic-clonic_seizures .
18289517	0	AMPA	62,66	GluR1	85,90	AMPA	GluR1	MESH:D018350	50592(Tax:10116)	Chemical	Gene	receptor|appos|START_ENTITY Role|nmod|receptor subunit|nsubj|Role subunit|dobj|END_ENTITY	Role of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate -LRB- AMPA -RRB- receptor subunit GluR1 in spinal dorsal horn in inflammatory nociception and neuropathic_nociception in rat .
18294632	0	AMPA	76,80	GluR1	81,86	AMPA	GluR1	MESH:D018350	50592(Tax:10116)	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	Chronic administration of morphine is associated with a decrease in surface AMPA GluR1 receptor subunit in dopamine D1 receptor expressing neurons in the shell and non-D1 receptor expressing neurons in the core of the rat nucleus accumbens .
18394473	0	AMPA	31,35	GluR1	24,29	AMPA	GluR1	MESH:D018350	14799(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	The role of the GluR-A -LRB- GluR1 -RRB- AMPA receptor subunit in learning and memory .
18486119	0	AMPA	67,71	GluR1	50,55	AMPA	GluR1	MESH:D018350	50592(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY containing|dobj|receptors END_ENTITY|acl|containing	Contributions of nucleus accumbens core and shell GluR1 containing AMPA receptors in AMPA - and cocaine-primed reinstatement of cocaine-seeking behavior .
18486119	0	AMPA	85,89	GluR1	50,55	AMPA	GluR1	MESH:D018350	50592(Tax:10116)	Chemical	Gene	containing|nmod|START_ENTITY END_ENTITY|acl|containing	Contributions of nucleus accumbens core and shell GluR1 containing AMPA receptors in AMPA - and cocaine-primed reinstatement of cocaine-seeking behavior .
18819435	0	AMPA	59,63	GluR1	53,58	AMPA	GluR1	MESH:D018350	2890	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	-LSB- Blockade of the alpha3alpha4 N-cholinoreceptors and GluR1 AMPA receptors eliminates clonic-tonic nicotinic and kainate seizures -RSB- .
18958186	0	AMPA	87,91	GluR1	92,97	AMPA	GluR1	MESH:D018350	14799(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Impaired associative fear learning in mice with complete loss_or_haploinsufficiency of AMPA GluR1 receptors .
19046328	0	AMPA	85,89	GluR1	24,29	AMPA	GluR1	MESH:D018350	2890	Chemical	Gene	trafficking|compound|START_ENTITY blocks|dobj|trafficking aptamer|acl:relcl|blocks phosphorylation|nmod|aptamer phosphorylation|nsubj|inhibition inhibition|nmod|Ser845 Ser845|amod|END_ENTITY	Targeting inhibition of GluR1 Ser845 phosphorylation with an RNA aptamer that blocks AMPA receptor trafficking .
19077125	0	AMPA	123,127	GluR1	106,111	AMPA	GluR1	MESH:D018350	50592(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY subunit|nmod|receptors subunit|amod|END_ENTITY	Extinction of morphine-dependent conditioned behavior is associated with increased phosphorylation of the GluR1 subunit of AMPA receptors at hippocampal synapses .
19922133	0	AMPA	24,28	GluR1	18,23	AMPA	GluR1	MESH:D018350	2890	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Interactions with GluR1 AMPA receptors could influence the therapeutic usefulness of minocycline in ALS .
19931598	0	AMPA	0,4	GluR1	22,27	AMPA	GluR1	MESH:D018350	50592(Tax:10116)	Chemical	Gene	downstream|compound|START_ENTITY downstream|compound|END_ENTITY	AMPA receptor subunit GluR1 downstream of D-1 dopamine receptor stimulation in nucleus accumbens shell mediates increased drug reward magnitude in food-restricted rats .
20553819	0	AMPA	79,83	GluR1	84,89	AMPA	GluR1	MESH:D018350	14799(Tax:10090)	Chemical	Gene	subunits|compound|START_ENTITY subunits|compound|END_ENTITY	Acute and chronic cocaine differentially alter the subcellular distribution of AMPA GluR1 subunits in region-specific neurons within the mouse ventral_tegmental_area .
21068335	0	AMPA	17,21	GluR1	125,130	AMPA	GluR1	MESH:D018350	2890	Chemical	Gene	internalization|compound|START_ENTITY internalization|nmod|neurons neurons|nmod|dephosphorylation dephosphorylation|nmod|subunits subunits|amod|END_ENTITY	Morphine induces AMPA receptor internalization in primary hippocampal neurons via calcineurin-dependent dephosphorylation of GluR1 subunits .
21848865	4	AMPA	826,830	GluR1	754,759	AMPA	GluR1	MESH:D018350	2890	Chemical	Gene	receptors|appos|START_ENTITY subunit|nmod|receptors subunit|appos|END_ENTITY	CPF potentiated protein kinase A -LRB- PKA -RRB- - dependent phosphorylation of the striatal protein dopamine - _ and_cAMP-regulated_phosphoprotein_of_M -LRB- r -RRB- _ 32_kDa -LRB- DARPP-32 -RRB- and the glutamate_receptor_1 -LRB- GluR1 -RRB- subunit of a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic_acid -LRB- AMPA -RRB- receptors in mouse brain slices .
24769307	0	AMPA	51,55	GluR1	65,70	AMPA	GluR1	MESH:D018350	14799(Tax:10090)	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	Exendin-4 promotes the membrane trafficking of the AMPA receptor GluR1 subunit and ADAM10 in the mouse neocortex .
24831997	0	AMPA	74,78	GluR1	88,93	AMPA	GluR1	MESH:D018350	50592(Tax:10116)	Chemical	Gene	Subunit|compound|START_ENTITY Subunit|compound|END_ENTITY	Effects of Low-Dose Ketamine Combined With Propofol on Phosphorylation of AMPA Receptor GluR1 Subunit and GABAA Receptor in Hippocampus of Stressed Rats Receiving Electroconvulsive Shock .
8663994	0	AMPA	58,62	GluR1	72,77	AMPA	GluR1	MESH:D018350	2890	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	Characterization of multiple phosphorylation sites on the AMPA receptor GluR1 subunit .
8725347	1	AMPA	280,284	GluR1	139,144	AMPA	GluR2	MESH:D018350	29627(Tax:10116)	Chemical	Gene	channels|appos|START_ENTITY calcium-permeable|dobj|channels leading|xcomp|calcium-permeable subunit|acl|leading subunit|amod|END_ENTITY	Recent in vitro studies suggest that inhibitory interneurons in cortex may express the GluR1 glutamate receptor subunit in the absence of GluR2 , leading to calcium-permeable alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate -LRB- AMPA -RRB- channels .
8987751	0	AMPA	66,70	GluR1	39,44	AMPA	GluR1	MESH:D018350	2890	Chemical	Gene	density|compound|START_ENTITY increases|dobj|density increases|nsubj|transcription transcription|nmod|END_ENTITY	Growth factor-induced transcription of GluR1 increases functional AMPA receptor density in glial progenitor cells .
9003049	0	AMPA	26,30	GluR1	49,54	AMPA	GluR1	MESH:D018350	2890	Chemical	Gene	receptor|compound|START_ENTITY expression|nmod|receptor subunits|nsubj|expression subunits|dobj|END_ENTITY	Surface expression of the AMPA receptor subunits GluR1 , GluR2 , and GluR4 in stably transfected baby hamster kidney cells .
9395130	0	AMPA	72,76	GluR1	55,60	AMPA	GluR1	MESH:D018350	2890	Chemical	Gene	receptor|compound|START_ENTITY presence|nmod|receptor presence|nmod|subunit subunit|amod|END_ENTITY	The presence of autoantibodies to N-terminus domain of GluR1 subunit of AMPA receptor in the blood serum of patients with epilepsy .
9459552	0	AMPA	14,18	GluR1	37,42	AMPA	GluR1	MESH:D018350	50592(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY Modulation|nmod|receptor subunits|nsubj|Modulation subunits|dobj|END_ENTITY	Modulation of AMPA receptor subunits GluR1 and GluR2/3 in the rat cerebellum in an experimental hepatic encephalopathy model .
9622199	3	AMPA	585,589	GluR1	662,667	AMPA	sPLA2	MESH:D018350	8399	Chemical	Gene	subunits|compound|START_ENTITY sPLA2|nmod|subunits interaction|nmod|sPLA2 due|nmod|interaction test|ccomp|due used|dep|test used|xcomp|expressing expressing|dobj|END_ENTITY	To test whether these results are due to the interaction of sPLA2 with different AMPA receptor subunits we used membranes from BHK cells expressing homomeric GluR1 , GluR2 or GluR4 receptors .
9798934	0	AMPA	97,101	GluR1	80,85	AMPA	GluR1	MESH:D018350	50592(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY Monitoring|nmod|receptors Monitoring|nmod|subunit subunit|amod|END_ENTITY	Monitoring of brain spiking activity and autoantibodies to N-terminus domain of GluR1 subunit of AMPA receptors in blood serum of rats with cobalt-induced epilepsy .
9856470	0	AMPA	89,93	GluR1	72,77	AMPA	GluR1	MESH:D018350	2890	Chemical	Gene	receptors|compound|START_ENTITY subunit|nmod|receptors subunit|amod|END_ENTITY	NMDA induces long-term synaptic depression and dephosphorylation of the GluR1 subunit of AMPA receptors in hippocampus .
10196565	0	AMPA	14,18	GluR2	50,55	AMPA	GluR2	MESH:D018350	14800(Tax:10090)	Chemical	Gene	block|compound|START_ENTITY block|nmod|mice mice|acl|lacking lacking|dobj|END_ENTITY	Use-dependent AMPA receptor block in mice lacking GluR2 suggests postsynaptic site for LTP expression .
10531425	0	AMPA	13,17	GluR2	27,32	AMPA	GluR2	MESH:D018350	2891	Chemical	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Knockdown of AMPA receptor GluR2 expression causes delayed neurodegeneration and increases damage by sublethal ischemia in hippocampal CA1 and CA3 neurons .
10551584	0	AMPA	148,152	GluR2	166,171	AMPA	GluR2	MESH:D018350	14800(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY sensitivity|nmod|receptors sensitivity|nmod|mice mice|amod|END_ENTITY	Blockade of glutamate receptors and barbiturate anesthesia : increased sensitivity to pentobarbital-induced anesthesia despite reduced inhibition of AMPA receptors in GluR2 null mutant mice .
10589532	0	AMPA	89,93	GluR2	13,18	AMPA	GluR2	MESH:D018350	2891	Chemical	Gene	receptors|compound|START_ENTITY increases|nmod|receptors change|acl:relcl|increases Reduction|appos|change Reduction|nmod|editing editing|compound|END_ENTITY	Reduction of GluR2 RNA editing , a molecular change that increases calcium influx through AMPA receptors , selective in the spinal ventral gray of patients with amyotrophic_lateral_sclerosis .
10627588	0	AMPA	0,4	GluR2	36,41	AMPA	GluR2	MESH:D018350	29627(Tax:10116)	Chemical	Gene	permeability|compound|START_ENTITY permeability|appos|expression expression|amod|END_ENTITY	AMPA receptor calcium permeability , GluR2 expression , and selective motoneuron vulnerability .
10665816	0	AMPA	55,59	GluR2	21,26	AMPA	GluR2	MESH:D018350	2891	Chemical	Gene	receptors|compound|START_ENTITY contributions|nmod|receptors contributions|nmod|END_ENTITY	The contributions of GluR2 to allosteric modulation of AMPA receptors .
10704491	0	AMPA	42,46	GluR2	36,41	AMPA	GluR2	MESH:D018350	100294514(Tax:8355)	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Regulation of kinetic properties of GluR2 AMPA receptor channels by alternative splicing .
10985351	0	AMPA	97,101	GluR2	51,56	AMPA	GluR2	MESH:D018350	2891	Chemical	Gene	receptor|compound|START_ENTITY accumulation|nmod|receptor END_ENTITY|nmod|accumulation	Mutagenesis reveals a role for ABP/GRIP binding to GluR2 in synaptic surface accumulation of the AMPA receptor .
11029547	12	AMPA	1745,1749	GluR2	1791,1796	AMPA	GluR2	MESH:D018350	29627(Tax:10116)	Chemical	Gene	START_ENTITY|dep|those those|acl|containing containing|dobj|subunit subunit|amod|END_ENTITY	These results also suggest that AMPA receptors , at least those containing the GluR2 subunit , have no major role as presynaptic receptors within this region .
11245820	0	AMPA	7,11	GluR2	29,34	AMPA	GluR2	MESH:D018350	29627(Tax:10116)	Chemical	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	Is the AMPA receptor subunit GluR2 mRNA an early indicator of cell fate after ischemia ?
11374610	0	AMPA	12,16	GluR2	88,93	AMPA	GluR2	MESH:D018350	14800(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY Blockade|nmod|receptors Blockade|dep|requirements requirements|nmod|mice mice|amod|END_ENTITY	Blockade of AMPA receptors and volatile anesthetics : reduced anesthetic requirements in GluR2 null mutant mice for loss of the righting reflex and antinociception but not minimum alveolar concentration .
11640921	0	AMPA	68,72	GluR2	82,87	AMPA	GluR2	MESH:D018350	2891	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	Identification of protein kinase C phosphorylation sites within the AMPA receptor GluR2 subunit .
11720711	0	AMPA	0,4	GluR2	5,10	AMPA	GluR2	MESH:D018350	29627(Tax:10116)	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	AMPA GluR2 subunit is differentially distributed on GABAergic neurons and pyramidal cells in the macaque monkey visual cortex .
12091530	0	AMPA	0,4	GluR2	64,69	AMPA	GluR2	MESH:D018350	14800(Tax:10090)	Chemical	Gene	receptor-mediated|nsubj|START_ENTITY receptor-mediated|nmod|mice mice|amod|END_ENTITY	AMPA receptor-mediated miniature synaptic calcium transients in GluR2 null mice .
12099896	0	AMPA	43,47	GluR2	14,19	AMPA	GluR2	MESH:D018350	29627(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY involvement|nmod|receptor involvement|amod|END_ENTITY	Evaluation of GluR2 subunit involvement in AMPA receptor function of neonatal rat hypoglossal motoneurons .
12215417	0	AMPA	21,25	GluR2	124,129	AMPA	GluR2	MESH:D018350	2891	Chemical	Gene	activation|compound|START_ENTITY basis|nmod|activation basis|dep|structures structures|nmod|complexes complexes|nmod|core core|amod|END_ENTITY	Structural basis for AMPA receptor activation and ligand selectivity : crystal structures of five agonist complexes with the GluR2 ligand-binding core .
12519060	0	AMPA	26,30	GluR2	113,118	AMPA	GluR2	MESH:D018350	2891	Chemical	Gene	receptors|compound|START_ENTITY antagonism|nmod|receptors antagonism|dep|structure structure|nmod|ATPO ATPO|acl|bound bound|nmod|core core|amod|END_ENTITY	Competitive antagonism of AMPA receptors by ligands of different classes : crystal structure of ATPO bound to the GluR2 ligand-binding core , in comparison with DNQX .
12606709	0	AMPA	82,86	GluR2	96,101	AMPA	GluR2	MESH:D018350	2891	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	Hypothermia rescues hippocampal CA1 neurons and attenuates down-regulation of the AMPA receptor GluR2 subunit after forebrain_ischemia .
14550765	0	AMPA	44,48	GluR2	88,93	AMPA	GluR2	MESH:D018350	29627(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY involvement|nmod|receptors involvement|nmod|subunit subunit|amod|END_ENTITY	Specific involvement in neuropathic_pain of AMPA receptors and adapter proteins for the GluR2 subunit .
14561864	0	AMPA	100,104	GluR2	94,99	AMPA	GluR2	MESH:D018350	14800(Tax:10090)	Chemical	Gene	subunit|compound|START_ENTITY subunit|amod|END_ENTITY	Aberrant formation of glutamate receptor complexes in hippocampal neurons of mice lacking the GluR2 AMPA receptor subunit .
14976558	0	AMPA	69,73	GluR2	28,33	AMPA	GluR2	MESH:D018350	2891	Chemical	Gene	endocytosis|compound|START_ENTITY required|nmod|endocytosis required|nsubjpass|phosphorylation phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of GluR2 is required for insulin-stimulated AMPA receptor endocytosis and LTD. .
15215299	0	AMPA	29,33	GluR2	43,48	AMPA	GluR2	MESH:D018350	29627(Tax:10116)	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	Widespread expression of the AMPA receptor GluR2 subunit at glutamatergic synapses in the rat spinal cord and phosphorylation of GluR1 in response to noxious stimulation revealed with an antigen-unmasking method .
15351509	0	AMPA	42,46	GluR2	26,31	AMPA	GluR2	MESH:D018350	29627(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	Predominant expression of GluR2 among the AMPA receptor subunits in neuronal progenitor cells of the rat hippocampus .
15794751	0	AMPA	71,75	GluR2	14,19	AMPA	GluR2	MESH:D018350	2891	Chemical	Gene	analogue|compound|START_ENTITY AHCP|nsubj|analogue AHCP|dep|Exploring Exploring|dobj|core core|amod|END_ENTITY	Exploring the GluR2 ligand-binding core in complex with the bicyclical AMPA analogue -LRB- S -RRB- -4 - AHCP .
16045445	0	AMPA	23,27	GluR2	17,22	AMPA	GluR2	MESH:D018350	29627(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Evidence for low GluR2 AMPA receptor subunit expression at synapses in the rat basolateral amygdala .
16055064	1	AMPA	100,104	GluR2	122,127	AMPA	PICK1	MESH:D018350	9463	Chemical	Gene	receptor|compound|START_ENTITY bind|nmod|receptor END_ENTITY|nsubj|bind	PICK1 and ABP/GRIP bind to the AMPA receptor -LRB- AMPAR -RRB- GluR2 subunit C terminus .
16215279	0	AMPA	0,4	GluR2	22,27	AMPA	GluR2	MESH:D018350	2891	Chemical	Gene	gates|compound|START_ENTITY gates|compound|END_ENTITY	AMPA receptor subunit GluR2 gates injurious signals in ischemic_stroke .
16262247	0	AMPA	31,35	GluR2	25,30	AMPA	GluR2	MESH:D018350	2891	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Binding of 5 ' - GMP to the GluR2 AMPA receptor : insight from targeted_molecular_dynamics simulations .
16543133	0	AMPA	34,38	GluR2	56,61	AMPA	GluR2	MESH:D018350	14800(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY mutations|nmod|receptor Targeted|nmod|mutations END_ENTITY|amod|Targeted	Targeted in vivo mutations of the AMPA receptor subunit GluR2 and its interacting protein PICK1 eliminate cerebellar long-term depression .
17024188	0	AMPA	93,97	GluR2	107,112	AMPA	GluR2	MESH:D018350	2891	Chemical	Gene	mRNA|compound|START_ENTITY mRNA|amod|END_ENTITY	CPEB3 and CPEB4 in neurons : analysis of RNA-binding specificity and translational control of AMPA receptor GluR2 mRNA .
17149707	0	AMPA	43,47	GluR2	48,53	AMPA	GluR2	MESH:D018350	14800(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Long-term_depression requires postsynaptic AMPA GluR2 receptor in adult mouse cingulate cortex .
17544687	0	AMPA	37,41	GluR2	31,36	AMPA	GluR2	MESH:D018350	2891	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Novel toxicity of the unedited GluR2 AMPA receptor subunit dependent on surface trafficking and increased Ca2 + - permeability .
17582328	0	AMPA	33,37	GluR2	16,21	AMPA	GluR2	MESH:D018350	2891	Chemical	Gene	function|compound|START_ENTITY role|nmod|function role|nmod|subunit subunit|amod|END_ENTITY	The role of the GluR2 subunit in AMPA receptor function and synaptic plasticity .
18077702	0	AMPA	62,66	GluR2	55,60	AMPA	GluR2	MESH:D018350	2891	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	PICK1 and phosphorylation of the glutamate_receptor_2 -LRB- GluR2 -RRB- AMPA receptor subunit regulates GluR2 recycling after NMDA receptor-induced internalization .
18077702	0	AMPA	62,66	GluR2	94,99	AMPA	GluR2	MESH:D018350	2891	Chemical	Gene	receptor|compound|START_ENTITY PICK1|nmod|receptor regulates|nsubj|PICK1 regulates|dobj|recycling recycling|amod|END_ENTITY	PICK1 and phosphorylation of the glutamate_receptor_2 -LRB- GluR2 -RRB- AMPA receptor subunit regulates GluR2 recycling after NMDA receptor-induced internalization .
18161947	0	AMPA	37,41	GluR2	31,36	AMPA	GluR2	MESH:D018350	2891	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Mechanism of inhibition of the GluR2 AMPA receptor channel opening by 2,3-benzodiazepine derivatives .
18367088	1	AMPA	184,188	GluR2	168,173	AMPA	PICK1	MESH:D018350	9463	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	PICK1 is a calcium-sensing , PDZ domain-containing protein that interacts with GluR2 and GluR3 AMPA receptor -LRB- AMPAR -RRB- subunits and regulates their trafficking .
18403631	0	AMPA	18,22	GluR2	57,62	AMPA	GluR2	MESH:D018350	2891	Chemical	Gene	receptors|compound|START_ENTITY receptors|acl|containing containing|dobj|END_ENTITY	Calcium-permeable AMPA receptors containing Q/R-unedited GluR2 direct human neural progenitor cell differentiation to neurons .
18754610	0	AMPA	115,119	GluR2	109,114	AMPA	GluR2	MESH:D018350	2891	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	6-Azido-7-nitro-1 ,4 - dihydroquinoxaline-2 ,3 - dione -LRB- ANQX -RRB- forms an irreversible bond to the active site of the GluR2 AMPA receptor .
19176091	0	AMPA	16,20	GluR2	39,44	AMPA	GluR2	MESH:D018350	29627(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY changes|nmod|receptors -LSB-|dobj|changes -RSB-|dep|-LSB- -RSB-|nsubj|END_ENTITY	-LSB- The changes of AMPA receptors subunit GluR2 and mEPSCs in visual cortex of monocular deprivation rats -RSB- .
19200070	0	AMPA	111,115	GluR2	139,144	AMPA	GluR2	MESH:D018350	29627(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|acl:relcl|contain contain|dobj|subunits subunits|amod|END_ENTITY	Neurokinin_1_receptor-expressing projection neurons in laminae III and IV of the rat spinal cord have synaptic AMPA receptors that contain GluR2 , GluR3 and GluR4 subunits .
19284741	0	AMPA	38,42	GluR2	32,37	AMPA	GluR2	MESH:D018350	2891	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Mechanisms of antagonism of the GluR2 AMPA receptor : structure and dynamics of the complex of two willardiine antagonists with the glutamate binding domain .
19330848	0	AMPA	23,27	GluR2	65,70	AMPA	GluR2	MESH:D018350	29627(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY modulation|nmod|receptors prevents|nsubj|modulation prevents|dobj|downregulation downregulation|nmod|expression expression|amod|END_ENTITY	Positive modulation of AMPA receptors prevents downregulation of GluR2 expression and activates the Lyn-ERK1 / 2-CREB signaling in rat brain_ischemia .
19458219	0	AMPA	51,55	GluR2	30,35	AMPA	GluR2	MESH:D018350	2891	Chemical	Gene	receptor|compound|START_ENTITY subunit|nmod|receptor subunit|amod|END_ENTITY	Synaptic scaling requires the GluR2 subunit of the AMPA receptor .
19908285	0	AMPA	21,25	GluR2	15,20	AMPA	GluR2	MESH:D018350	29627(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Alterations in GluR2 AMPA receptor phosphorylation at serine 880 following group I metabotropic glutamate receptor stimulation in the rat dorsal striatum .
20132465	0	AMPA	56,60	GluR2	156,161	AMPA	GluR2	MESH:D018350	14800(Tax:10090)	Chemical	Gene	entry|compound|START_ENTITY reduction|nmod|entry induces|dobj|reduction induces|nmod|expression expression|nmod|subunit subunit|amod|END_ENTITY	Tumour necrosis factor alpha induces rapid reduction in AMPA receptor-mediated calcium entry in motor neurones by increasing cell surface expression of the GluR2 subunit : relevance to neurodegeneration .
20571220	0	AMPA	36,40	GluR2	110,115	AMPA	GluR2	MESH:D018350	2891	Chemical	Gene	receptors|compound|START_ENTITY decreases|dobj|receptors decreases|advcl|increasing increasing|dobj|calcium calcium|nmod|END_ENTITY	Amyloid-beta decreases cell-surface AMPA receptors by increasing intracellular calcium and phosphorylation of GluR2 .
20849926	0	AMPA	62,66	GluR2	84,89	AMPA	GluR2	MESH:D018350	2891	Chemical	Gene	subunit|compound|START_ENTITY colocalize|nmod|subunit END_ENTITY|amod|colocalize	A subpopulation of serotonin 1B receptors colocalize with the AMPA receptor subunit GluR2 in the hippocampal dentate gyrus .
21419184	0	AMPA	16,20	GluR2	30,35	AMPA	GluR2	MESH:D018350	2891	Chemical	Gene	subunits|compound|START_ENTITY subunits|compound|END_ENTITY	Upregulation of AMPA receptor GluR2 -LRB- GluA2 -RRB- subunits in subcortical_ischemic_vascular_dementia is repressed in the presence of Alzheimer 's _ disease .
26311781	0	AMPA	58,62	GluR2	191,196	AMPA	GluR2	MESH:D018350	14800(Tax:10090)	Chemical	Gene	Receptors|compound|START_ENTITY Receptors|dep|Migration Migration|nmod|Modulation Modulation|nmod|Expression Expression|compound|END_ENTITY	Myelin Proteolipid Protein Complexes with av Integrin and AMPA Receptors In Vivo and Regulates AMPA-Dependent Oligodendrocyte Progenitor Cell Migration through the Modulation of Cell-Surface GluR2 Expression .
26961610	5	AMPA	873,877	GluR2	823,828	AMPA	GluR3	MESH:D018350	29628(Tax:10116)	Chemical	Gene	GluR1|compound|START_ENTITY expression|nmod|GluR1 change|nsubj|expression decreased|parataxis|change decreased|dobj|expression expression|amod|END_ENTITY	Treatment of cultured rat cortical neurons with 1 or 10 M methoxychlor and fenvalerate for 9 days selectively decreased GluR2 protein expression ; the expression of other AMPA receptor subunits GluR1 , GluR3 , and GluR4 did not change under the same conditions .
9246466	0	AMPA	39,43	GluR2	4,9	AMPA	GluR2	MESH:D018350	2891	Chemical	Gene	receptors|compound|START_ENTITY permeable|dobj|receptors permeable|nsubj|hypothesis hypothesis|amod|END_ENTITY	The GluR2 hypothesis : Ca -LRB- + + -RRB- - permeable AMPA receptors in delayed neurodegeneration .
9246466	5	AMPA	710,714	GluR2	779,784	AMPA	GluR2	MESH:D018350	2891	Chemical	Gene	receptors|compound|START_ENTITY hetero-oligomers|nsubj|receptors hetero-oligomers|dep|containing containing|dobj|subunits subunits|amod|END_ENTITY	AMPA receptors in most adult neurons are hetero-oligomers containing GluR2 subunits , but some neurons have GluR2-less , Ca -LRB- + + -RRB- - permeable receptors .
9347614	0	AMPA	48,52	GluR2	4,9	AMPA	GluR2	MESH:D018350	2891	Chemical	Gene	receptors|nummod|START_ENTITY +|dep|receptors +|nsubj|END_ENTITY	The GluR2 -LRB- GluR-B -RRB- hypothesis : Ca -LRB- 2 + -RRB- - permeable AMPA receptors in neurological_disorders .
9390995	0	AMPA	80,84	GluR2	27,32	AMPA	GluR2	MESH:D018350	100294514(Tax:8355)	Chemical	Gene	receptors|compound|START_ENTITY features|nmod|receptors dependence|nmod|features dependence|nmod|expression expression|amod|END_ENTITY	Differential dependence on GluR2 expression of three characteristic features of AMPA receptors .
9619504	0	AMPA	51,55	GluR2	74,79	AMPA	GluR2	MESH:D018350	14800(Tax:10090)	Chemical	Gene	subunit|compound|START_ENTITY subunit|appos|END_ENTITY	Light and electron microscopic distribution of the AMPA receptor subunit , GluR2 , in the spinal cord of control and G86R mutant superoxide_dismutase transgenic_mice .
9645970	0	AMPA	40,44	GluR2	34,39	AMPA	GluR2	MESH:D018350	100379153(Tax:10141)	Chemical	Gene	subunit|compound|START_ENTITY subunit|amod|END_ENTITY	Antisense oligonucleotides to the GluR2 AMPA receptor subunit modify excitatory synaptic transmission in vivo .
9697855	0	AMPA	4,8	GluR2	18,23	AMPA	GluR2	MESH:D018350	2891	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|nsubj|receptor	The AMPA receptor GluR2 C terminus can mediate a reversible , ATP-dependent interaction with NSF and alpha - _ and_beta-SNAPs .
14651263	0	AMPA	58,62	GluR2/3	63,70	AMPA	GluR2/3	MESH:D018350	2892	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	Immunocytochemical localization of neurons containing the AMPA GluR2/3 subunit in the hamster visual cortex .
15749979	0	AMPA	117,121	GluR2/3	66,73	AMPA	GluR2/3	MESH:D018350	29627;29628	Chemical	Gene	trafficking|compound|START_ENTITY exhibiting|dobj|trafficking synapses|acl|exhibiting subunits|nmod|synapses subunits|nsubj|co-localization co-localization|nmod|MCT2 MCT2|nmod|END_ENTITY	Selective postsynaptic co-localization of MCT2 with AMPA receptor GluR2/3 subunits at excitatory synapses exhibiting AMPA receptor trafficking .
18195348	0	AMPA	29,33	GluR2/3	52,59	AMPA	GluR2/3	MESH:D018350	2891;2892	Chemical	Gene	Endocytosis|nmod|START_ENTITY receptors|nsubj|Endocytosis receptors|xcomp|lacking lacking|dobj|END_ENTITY	Endocytosis and recycling of AMPA receptors lacking GluR2/3 .
9045077	0	AMPA	0,4	GluR2/3	73,80	AMPA	GluR2/3	MESH:D018350	29627;29628	Chemical	Gene	receptors|compound|START_ENTITY receptors|dep|absence absence|nmod|subunits subunits|amod|END_ENTITY	AMPA receptors in the rat and primate hippocampus : a possible absence of GluR2/3 subunits in most interneurons .
9875351	0	AMPA	192,196	GluR2/3	169,176	AMPA	GluR2/3	MESH:D018350	29628(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY subunit|nmod|receptor subunit|amod|END_ENTITY	Subcellular and subsynaptic distribution of the NR1 subunit of the NMDA receptor in the neostriatum and globus pallidus of the rat : co-localization at synapses with the GluR2/3 subunit of the AMPA receptor .
11054828	0	AMPA	185,189	GluR3	157,162	AMPA	GluR3	MESH:D018350	100294516(Tax:8355)	Chemical	Gene	agonist|compound|START_ENTITY agonist|amod|END_ENTITY	Resolution , configurational assignment , and enantiopharmacology of 2-amino-3 - -LSB- 3-hydroxy-5 - -LRB- 2-methyl-2H - _ tetrazol-5-yl -RRB- isoxazol-4-yl -RSB- propionic_acid , a potent GluR3 - and GluR4-preferring AMPA receptor agonist .
16967334	0	AMPA	127,131	GluR3	55,60	AMPA	GluR3	MESH:D018350	100294516(Tax:8355)	Chemical	Gene	channels|compound|START_ENTITY activate|dobj|channels activate|nsubj|Autoantibodies Autoantibodies|nmod|peptide peptide|nmod|subtype subtype|amod|END_ENTITY	Autoantibodies against an extracellular peptide of the GluR3 subtype of AMPA receptors activate both homomeric and heteromeric AMPA receptor channels .
16967334	0	AMPA	72,76	GluR3	55,60	AMPA	GluR3	MESH:D018350	100294516(Tax:8355)	Chemical	Gene	receptors|compound|START_ENTITY subtype|nmod|receptors subtype|amod|END_ENTITY	Autoantibodies against an extracellular peptide of the GluR3 subtype of AMPA receptors activate both homomeric and heteromeric AMPA receptor channels .
17256974	7	AMPA	1310,1314	GluR3	1409,1414	AMPA	GluR1	MESH:D018350	2890	Chemical	Gene	subunits|compound|START_ENTITY isoform|nmod|subunits comparison|nmod|isoform suggests|nsubj|comparison suggests|ccomp|similar similar|nsubj|END_ENTITY	Furthermore , a comparison of the flip isoform among all AMPA receptor subunits , based on the magnitude of the channel opening rate constant , suggests that GluR3 is kinetically more similar to GluR2 and GluR4 than to GluR1 .
18395463	0	AMPA	21,25	GluR3	26,31	AMPA	GluR3	MESH:D018350	2892	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	The fast kinetics of AMPA GluR3 receptors is selectively modulated by the TARPs gamma 4 and gamma 8 .
12497607	0	AMPA	28,32	GluR4	50,55	AMPA	GluR4	MESH:D018350	2893	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Positive association of the AMPA receptor subunit GluR4 gene -LRB- GRIA4 -RRB- haplotype with schizophrenia : linkage disequilibrium mapping using SNPs evenly distributed across the gene region .
12524178	0	AMPA	106,110	GluR4	100,105	AMPA	GluR4	MESH:D018350	396137(Tax:9031)	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	Development of chick retina cells in culture : cobalt entry through AMPA receptors and expression of GluR4 AMPA receptor subunit .
12524178	0	AMPA	67,71	GluR4	100,105	AMPA	GluR4	MESH:D018350	396137(Tax:9031)	Chemical	Gene	receptors|compound|START_ENTITY entry|nmod|receptors entry|nmod|subunit subunit|compound|END_ENTITY	Development of chick retina cells in culture : cobalt entry through AMPA receptors and expression of GluR4 AMPA receptor subunit .
15255946	0	AMPA	58,62	GluR4	139,144	AMPA	GluR4	MESH:D018350	396137(Tax:9031)	Chemical	Gene	activity|compound|START_ENTITY glutamate|dobj|activity glutamate|nmod|neurones neurones|dep|effect effect|nmod|phosphorylation phosphorylation|amod|END_ENTITY	Metabotropic glutamate and dopamine receptors co-regulate AMPA receptor activity through PKA in cultured chick retinal neurones : effect on GluR4 phosphorylation and surface expression .
15450689	0	AMPA	52,56	GluR4	74,79	AMPA	GluR4	MESH:D018350	2893	Chemical	Gene	receptor|compound|START_ENTITY polymorphisms|nmod|receptor association|nmod|polymorphisms subunit|nsubj|association subunit|dobj|gene gene|amod|END_ENTITY	No genetic association between polymorphisms in the AMPA receptor subunit GluR4 gene -LRB- GRIA4 -RRB- and schizophrenia in the Chinese population .
17233759	0	AMPA	23,27	GluR4	17,22	AMPA	GluR4	MESH:D018350	29629(Tax:10116)	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	PKC anchoring to GluR4 AMPA receptor subunit modulates PKC-driven receptor phosphorylation and surface expression .
17610819	0	AMPA	44,48	GluR4	113,118	AMPA	GluR4	MESH:D018350	2893	Chemical	Gene	subunit|compound|START_ENTITY domain|nmod|subunit Interaction|nmod|domain mediates|nsubj|Interaction mediates|dobj|recruitment recruitment|amod|END_ENTITY	Interaction of the N-terminal domain of the AMPA receptor GluR4 subunit with the neuronal pentraxin NP1 mediates GluR4 synaptic recruitment .
17610819	0	AMPA	44,48	GluR4	58,63	AMPA	GluR4	MESH:D018350	2893	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	Interaction of the N-terminal domain of the AMPA receptor GluR4 subunit with the neuronal pentraxin NP1 mediates GluR4 synaptic recruitment .
19102704	0	AMPA	12,16	GluR4	98,103	AMPA	GluR4	MESH:D018350	2893	Chemical	Gene	activation|compound|START_ENTITY activation|dep|structures structures|nmod|ligand-binding_domain ligand-binding_domain|amod|END_ENTITY	Correlating AMPA receptor activation and cleft closure across subunits : crystal structures of the GluR4 ligand-binding_domain in complex with full and partial agonists .
16626814	0	AMPA	29,33	Interleukin-1_beta	0,18	AMPA	Interleukin-1 beta	MESH:D018350	3553	Chemical	Gene	START_ENTITY|nsubj|modulates modulates|amod|END_ENTITY	Interleukin-1_beta modulates AMPA receptor expression and phosphorylation in hippocampal neurons .
26631461	0	AMPA	27,31	KCC2	0,4	AMPA	KCC2	MESH:D018350	171373(Tax:10116)	Chemical	Gene	Traffic|compound|START_ENTITY Traffic|compound|END_ENTITY	KCC2 Gates Activity-Driven AMPA Receptor Traffic through Cofilin Phosphorylation .
21943600	0	AMPA	14,18	KIBRA	73,78	AMPA	KIBRA	MESH:D018350	23286	Chemical	Gene	receptor|compound|START_ENTITY Regulation|nmod|receptor function|nsubj|Regulation function|nmod|END_ENTITY	Regulation of AMPA receptor function by the human memory-associated gene KIBRA .
19151600	0	AMPA	0,4	NR1	35,38	AMPA	NR1	MESH:D018350	24408(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|nmod|END_ENTITY	AMPA reduces surface expression of NR1 through regulation of GSK3beta .
9875351	0	AMPA	192,196	NR1	48,51	AMPA	NR1	MESH:D018350	24408(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY subunit|nmod|receptor synapses|nmod|subunit co-localization|nmod|synapses distribution|dep|co-localization distribution|nmod|subunit subunit|compound|END_ENTITY	Subcellular and subsynaptic distribution of the NR1 subunit of the NMDA receptor in the neostriatum and globus pallidus of the rat : co-localization at synapses with the GluR2/3 subunit of the AMPA receptor .
10399937	0	AMPA	23,27	Narp	88,92	AMPA	Narp	MESH:D018350	4885	Chemical	Gene	clustering|nmod|START_ENTITY receptors|nsubj|clustering receptors|nmod|END_ENTITY	Synaptic clustering of AMPA receptors by the extracellular immediate-early gene product Narp .
10027300	0	AMPA	14,18	PICK1	75,80	AMPA	PICK1	MESH:D018350	9463	Chemical	Gene	Clustering|nmod|START_ENTITY receptors|nsubj|Clustering receptors|nmod|END_ENTITY	Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1 .
10340301	0	AMPA	119,123	PICK1	43,48	AMPA	PICK1	MESH:D018350	9463	Chemical	Gene	subunits|compound|START_ENTITY variants|nmod|subunits interacts|nmod|variants interacts|nsubj|END_ENTITY	The protein_kinase_C_alpha binding protein PICK1 interacts with short but not long form alternative splice variants of AMPA receptor subunits .
11466413	0	AMPA	49,53	PICK1	0,5	AMPA	PICK1	MESH:D018350	9463	Chemical	Gene	clusters|compound|START_ENTITY Calpha|nmod|clusters targets|ccomp|Calpha targets|nsubj|END_ENTITY	PICK1 targets activated protein kinase Calpha to AMPA receptor clusters in spines of hippocampal neurons and reduces surface levels of the AMPA-type glutamate receptor subunit 2 .
16055064	0	AMPA	42,46	PICK1	0,5	AMPA	PICK1	MESH:D018350	9463	Chemical	Gene	trafficking|compound|START_ENTITY regulate|dobj|trafficking interacts|xcomp|regulate interacts|nsubj|END_ENTITY	PICK1 interacts with ABP/GRIP to regulate AMPA receptor trafficking .
18077702	0	AMPA	62,66	PICK1	0,5	AMPA	PICK1	MESH:D018350	9463	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	PICK1 and phosphorylation of the glutamate_receptor_2 -LRB- GluR2 -RRB- AMPA receptor subunit regulates GluR2 recycling after NMDA receptor-induced internalization .
18353440	0	AMPA	37,41	PICK1	0,5	AMPA	PICK1	MESH:D018350	9463	Chemical	Gene	trafficking|compound|START_ENTITY modulator|nmod|trafficking END_ENTITY|dep|modulator	PICK1 : a multi-talented modulator of AMPA receptor trafficking .
20403402	0	AMPA	56,60	PICK1	34,39	AMPA	PICK1	MESH:D018350	9463	Chemical	Gene	interaction|compound|START_ENTITY critical|nmod|interaction critical|nsubj|Threonine Threonine|nmod|domain domain|nmod|END_ENTITY	Threonine 82 at the PDZ domain of PICK1 is critical for AMPA receptor interaction and localization .
21147983	0	AMPA	73,77	PICK1	19,24	AMPA	PICK1	MESH:D018350	9463	Chemical	Gene	receptors|compound|START_ENTITY retention|nmod|receptors essential|nmod|retention essential|nsubj|binding binding|nmod|END_ENTITY	Calcium binding to PICK1 is essential for the intracellular retention of AMPA receptors underlying long-term depression .
22915106	0	AMPA	100,104	PICK1	0,5	AMPA	PICK1	MESH:D018350	84591(Tax:10116)	Chemical	Gene	trafficking|compound|START_ENTITY mediates|nmod|trafficking mediates|nsubj|END_ENTITY	PICK1 mediates transient synaptic expression of GluA2-lacking AMPA receptors during glycine-induced AMPA receptor trafficking .
22915106	0	AMPA	62,66	PICK1	0,5	AMPA	PICK1	MESH:D018350	84591(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY expression|nmod|receptors mediates|dobj|expression mediates|nsubj|END_ENTITY	PICK1 mediates transient synaptic expression of GluA2-lacking AMPA receptors during glycine-induced AMPA receptor trafficking .
23918399	0	AMPA	40,44	PICK1	0,5	AMPA	PICK1	MESH:D018350	9463	Chemical	Gene	internalization|amod|START_ENTITY regulate|dobj|internalization interacts|xcomp|regulate interacts|nsubj|END_ENTITY	PICK1 interacts with PACSIN to regulate AMPA receptor internalization and cerebellar long-term depression .
25392508	0	AMPA	39,43	PICK1	0,5	AMPA	PICK1	MESH:D018350	84591(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY recruitment|nmod|receptors mediates|dobj|recruitment mediates|nsubj|END_ENTITY	PICK1 mediates synaptic recruitment of AMPA receptors at neurexin-induced postsynaptic sites .
25475687	0	AMPA	12,16	PICK1	0,5	AMPA	PICK1	MESH:D018350	9463	Chemical	Gene	stimulation|compound|START_ENTITY links|dobj|stimulation links|nsubj|END_ENTITY	PICK1 links AMPA receptor stimulation to Cdc42 .
19172179	0	AMPA	59,63	PMK-3	44,49	AMPA	PMK-3	MESH:D018350	177610(Tax:6239)	Chemical	Gene	trafficking|compound|START_ENTITY trafficking|compound|END_ENTITY	The ubiquitin ligase RPM-1 and the p38 MAPK PMK-3 regulate AMPA receptor trafficking .
12122038	0	AMPA	165,169	PSD-95	132,138	AMPA	PSD-95	MESH:D018350	1742	Chemical	Gene	receptors|compound|START_ENTITY END_ENTITY|nmod|receptors	Phosphorylation of the postsynaptic_density-95 -LRB- PSD-95 -RRB- / discs large/zona _ occludens-1 binding site of stargazin regulates binding to PSD-95 and synaptic targeting of AMPA receptors .
12122038	0	AMPA	165,169	PSD-95	48,54	AMPA	PSD-95	MESH:D018350	1742	Chemical	Gene	receptors|compound|START_ENTITY PSD-95|nmod|receptors binding|nmod|PSD-95 regulates|xcomp|binding regulates|nsubj|Phosphorylation Phosphorylation|nmod|site site|appos|END_ENTITY	Phosphorylation of the postsynaptic_density-95 -LRB- PSD-95 -RRB- / discs large/zona _ occludens-1 binding site of stargazin regulates binding to PSD-95 and synaptic targeting of AMPA receptors .
12359873	0	AMPA	66,70	PSD-95	28,34	AMPA	PSD-95	MESH:D018350	1742	Chemical	Gene	number|compound|START_ENTITY control|dobj|number control|nsubj|interactions interactions|nmod|END_ENTITY	Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number .
15458848	0	AMPA	51,55	PSD-95	69,75	AMPA	PSD-95	MESH:D018350	1742	Chemical	Gene	receptors|compound|START_ENTITY phosphorylation|nmod|receptors mediated|dobj|phosphorylation mediated|nmod|END_ENTITY	Modulation of dopamine mediated phosphorylation of AMPA receptors by PSD-95 and AKAP79/150 .
15784649	0	AMPA	91,95	PSD-95	132,138	AMPA	PSD-95	MESH:D018350	29495(Tax:10116)	Chemical	Gene	receptors|appos|START_ENTITY modulation|nmod|receptors induces|nsubj|modulation induces|dobj|END_ENTITY	Prolonged positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic_acid -LRB- AMPA -RRB- receptors induces calpain-mediated PSD-95 / Dlg/ZO -1 protein degradation and AMPA receptor down-regulation in cultured hippocampal slices .
16815335	0	AMPA	100,104	PSD-95	34,40	AMPA	PSD-95	MESH:D018350	1742	Chemical	Gene	function|compound|START_ENTITY regulation|nmod|function govern|dobj|regulation govern|nsubj|domains domains|nmod|END_ENTITY	Alternative N-terminal domains of PSD-95 and SAP97 govern activity-dependent regulation of synaptic AMPA receptor function .
17148601	0	AMPA	31,35	PSD-95	57,63	AMPA	PSD-95	MESH:D018350	13385(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY regulation|nmod|receptor function|nsubj|regulation function|nmod|END_ENTITY	Synapse-specific regulation of AMPA receptor function by PSD-95 .
19169250	0	AMPA	72,76	PSD-95	20,26	AMPA	PSD-95	MESH:D018350	29495(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY endocytosis|nmod|receptors interactions|nmod|endocytosis AKAP|dobj|interactions AKAP|nsubj|role role|nmod|/ /|compound|END_ENTITY	A critical role for PSD-95 / AKAP interactions in endocytosis of synaptic AMPA receptors .
22051694	0	AMPA	14,18	PSD-95	49,55	AMPA	PSD-95	MESH:D018350	1742	Chemical	Gene	receptor|compound|START_ENTITY Regulation|nmod|receptor surface|nsubj|Regulation surface|nmod|slots slots|compound|END_ENTITY	Regulation of AMPA receptor surface diffusion by PSD-95 slots .
23342049	0	AMPA	42,46	PSD-95	22,28	AMPA	PSD-95	MESH:D018350	29495(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY destabilizes|dobj|receptors destabilizes|nsubj|inactivation inactivation|nmod|END_ENTITY	Acute inactivation of PSD-95 destabilizes AMPA receptors at hippocampal synapses .
26604311	0	AMPA	49,53	PSD-95	0,6	AMPA	PSD-95	MESH:D018350	1742	Chemical	Gene	complexes|compound|START_ENTITY anchoring|dobj|complexes essential|advcl|anchoring essential|nsubj|MAGUKs MAGUKs|compound|END_ENTITY	PSD-95 family MAGUKs are essential for anchoring AMPA and NMDA receptor complexes at the postsynaptic density .
11498531	0	AMPA	88,92	Pick1	181,186	AMPA	Pick1	MESH:D018350	9463	Chemical	Gene	alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic_acid|dep|START_ENTITY down-regulation|amod|alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic_acid involves|nsubj|down-regulation involves|dobj|interaction interaction|nmod|terminus terminus|nmod|GluR2/3 GluR2/3|nmod|END_ENTITY	N-methyl-D-aspartate-induced alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic_acid -LRB- AMPA -RRB- receptor down-regulation involves interaction of the carboxyl terminus of GluR2/3 with Pick1 .
19104036	0	AMPA	28,32	SAP102	55,61	AMPA	SAP102	MESH:D018350	53310(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|nmod|END_ENTITY	Differential trafficking of AMPA and NMDA receptors by SAP102 and PSD-95 underlies synapse development .
11140673	0	AMPA	42,46	Stargazin	0,9	AMPA	Stargazin	MESH:D018350	12300(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY synaptic|nmod|receptors regulates|dobj|synaptic regulates|nsubj|END_ENTITY	Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms .
15473971	0	AMPA	0,4	Stargazin	77,86	AMPA	Stargazin	MESH:D018350	10369	Chemical	Gene	clustering|compound|START_ENTITY mediated|nsubjpass|clustering mediated|nmod|END_ENTITY	AMPA receptor-dependent clustering of synaptic NMDA receptors is mediated by Stargazin and NR2A/B in spinal neurons and hippocampal interneurons .
15630087	0	AMPA	16,20	Stargazin	0,9	AMPA	Stargazin	MESH:D018350	10369	Chemical	Gene	subunit|compound|START_ENTITY subunit|nsubj|END_ENTITY	Stargazin is an AMPA receptor auxiliary subunit .
15858532	0	AMPA	20,24	Stargazin	0,9	AMPA	Stargazin	MESH:D018350	10369	Chemical	Gene	gating|compound|START_ENTITY modulates|dobj|gating modulates|nsubj|END_ENTITY	Stargazin modulates AMPA receptor gating and trafficking by distinct domains .
16093395	0	AMPA	27,31	Stargazin	0,9	AMPA	Stargazin	MESH:D018350	10369	Chemical	Gene	properties|compound|START_ENTITY modulates|dobj|properties modulates|nsubj|END_ENTITY	Stargazin modulates native AMPA receptor functional properties by two distinct mechanisms .
16785437	0	AMPA	39,43	Stargazin	0,9	AMPA	Stargazin	MESH:D018350	10369	Chemical	Gene	potentiators|compound|START_ENTITY pharmacology|nmod|potentiators controls|dobj|pharmacology controls|nsubj|END_ENTITY	Stargazin controls the pharmacology of AMPA receptor potentiators .
16919685	0	AMPA	42,46	Stargazin	0,9	AMPA	Stargazin	MESH:D018350	10369	Chemical	Gene	module|compound|START_ENTITY interacts|nmod|module interacts|nsubj|END_ENTITY	Stargazin interacts functionally with the AMPA receptor glutamate-binding module .
17329211	0	AMPA	55,59	Stargazin	24,33	AMPA	Stargazin	MESH:D018350	10369	Chemical	Gene	trafficking|compound|START_ENTITY regulates|dobj|trafficking regulates|nsubj|interaction interaction|nmod|END_ENTITY	The interaction between Stargazin and PSD-95 regulates AMPA receptor surface trafficking .
17483093	0	AMPA	82,86	Stargazin	0,9	AMPA	Stargazin	MESH:D018350	10369	Chemical	Gene	receptors|appos|START_ENTITY interaction|nmod|receptors interaction|compound|END_ENTITY	Stargazin interaction with alpha-amino-3-hydroxy-5-methyl-4-isoxazole_propionate -LRB- AMPA -RRB- receptors is critically dependent on the amino_acid at the narrow constriction of the ion channel .
18378265	0	AMPA	20,24	Stargazin	0,9	AMPA	Stargazin	MESH:D018350	10369	Chemical	Gene	antagonism|compound|START_ENTITY modulates|dobj|antagonism modulates|nsubj|END_ENTITY	Stargazin modulates AMPA receptor antagonism .
21411637	0	AMPA	62,66	Stargazin	0,9	AMPA	Stargazin	MESH:D018350	12300(Tax:10090)	Chemical	Gene	trafficking|compound|START_ENTITY required|nmod|trafficking required|nsubjpass|END_ENTITY	Stargazin -LRB- TARP_gamma-2 -RRB- is required for compartment-specific AMPA receptor trafficking and synaptic plasticity in cerebellar stellate cells .
24217640	0	AMPA	20,24	Stargazin	0,9	AMPA	Stargazin	MESH:D018350	10369	Chemical	Gene	trafficking|compound|START_ENTITY regulates|dobj|trafficking regulates|nsubj|END_ENTITY	Stargazin regulates AMPA receptor trafficking through adaptor protein complexes during long-term depression .
25422502	0	AMPA	34,38	Stargazin	0,9	AMPA	Stargazin	MESH:D018350	10369	Chemical	Gene	ligand-binding_domain|compound|START_ENTITY closure|nmod|ligand-binding_domain promotes|dobj|closure promotes|nsubj|END_ENTITY	Stargazin promotes closure of the AMPA receptor ligand-binding_domain .
12885434	0	AMPA	69,73	Tumor_necrosis_factor_alpha	0,27	AMPA	Tumor necrosis factor alpha	MESH:D018350	24835(Tax:10116)	Chemical	Gene	increases|nmod|START_ENTITY increases|nsubj|END_ENTITY	Tumor_necrosis_factor_alpha increases cytosolic calcium responses to AMPA and KCl in primary cultures of rat hippocampal neurons .
12565696	0	AMPA	0,4	acetylcholinesterase	30,50	AMPA	acetylcholinesterase	MESH:D018350	83817(Tax:10116)	Chemical	Gene	potentiation|compound|START_ENTITY potentiation|nmod|END_ENTITY	AMPA receptor potentiation by acetylcholinesterase is age-dependently upregulated at synaptogenesis sites of the rat brain .
12025817	0	AMPA	66,70	caspase-3	83,92	AMPA	caspase-3	MESH:D018350	25402(Tax:10116)	Chemical	Gene	currents|compound|START_ENTITY currents|nmod|END_ENTITY	Direct cleavage of AMPA receptor subunit GluR1 and suppression of AMPA currents by caspase-3 : implications for synaptic plasticity and excitotoxic neuronal_death .
22211840	0	AMPA	0,4	cornichon-2	28,39	AMPA	cornichon-2	MESH:D018350	254263	Chemical	Gene	modulation|compound|START_ENTITY modulation|nmod|END_ENTITY	AMPA receptor modulation by cornichon-2 dictated by transmembrane_AMPA receptor regulatory protein isoform .
14985442	0	AMPA	58,62	flip	53,57	AMPA	flip	MESH:D018350	8837	Chemical	Gene	subunits|compound|START_ENTITY subunits|amod|END_ENTITY	Enhanced relative expression of glutamate receptor 1 flip AMPA receptor subunits in hippocampal astrocytes of epilepsy patients with Ammon 's horn_sclerosis .
17592947	0	AMPA	42,46	glutamate_receptor-A	12,32	AMPA	glutamate receptor-A	MESH:D018350	14799(Tax:10090)	Chemical	Gene	subunits|amod|START_ENTITY subunits|amod|END_ENTITY	Deletion of glutamate_receptor-A -LRB- GluR-A -RRB- AMPA receptor subunits impairs one-trial spatial memory .
15745962	0	AMPA	105,109	glutamate_receptor_1	119,139	AMPA	glutamate receptor 1	MESH:D018350	14799(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY deletion|nmod|receptor mice|nmod|deletion responding|nmod|mice instrumental|dep|responding subunit|amod|instrumental subunit|amod|END_ENTITY	Impaired outcome-specific devaluation of instrumental responding in mice with a targeted deletion of the AMPA receptor glutamate_receptor_1 subunit .
18045915	0	AMPA	42,46	glutamate_receptor_1	56,76	AMPA	glutamate receptor 1	MESH:D018350	2890	Chemical	Gene	subunits|compound|START_ENTITY subunits|compound|END_ENTITY	NMDA receptor activation dephosphorylates AMPA receptor glutamate_receptor_1 subunits at threonine 840 .
18077702	0	AMPA	62,66	glutamate_receptor_2	33,53	AMPA	glutamate receptor 2	MESH:D018350	2891	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	PICK1 and phosphorylation of the glutamate_receptor_2 -LRB- GluR2 -RRB- AMPA receptor subunit regulates GluR2 recycling after NMDA receptor-induced internalization .
23537341	0	AMPA	33,37	interleukin-1b	15,29	AMPA	interleukin-1b	MESH:D018350	24494(Tax:10116)	Chemical	Gene	currents|compound|START_ENTITY END_ENTITY|nmod|currents	Enhancement by interleukin-1b of AMPA and NMDA receptor-mediated currents in adult rat spinal superficial dorsal horn neurons .
12122038	0	AMPA	165,169	stargazin	101,110	AMPA	stargazin	MESH:D018350	10369	Chemical	Gene	receptors|compound|START_ENTITY PSD-95|nmod|receptors binding|nmod|PSD-95 regulates|xcomp|binding regulates|nsubj|Phosphorylation Phosphorylation|nmod|site site|nmod|END_ENTITY	Phosphorylation of the postsynaptic_density-95 -LRB- PSD-95 -RRB- / discs large/zona _ occludens-1 binding site of stargazin regulates binding to PSD-95 and synaptic targeting of AMPA receptors .
15329396	0	AMPA	0,4	stargazin	46,55	AMPA	stargazin	MESH:D018350	10369	Chemical	Gene	synaptic|compound|START_ENTITY regulated|nsubj|synaptic regulated|nmod|interactions interactions|compound|END_ENTITY	AMPA receptor synaptic targeting regulated by stargazin interactions with the Golgi-resident PDZ protein nPIST .
15567474	0	AMPA	46,50	stargazin	18,27	AMPA	stargazin	MESH:D018350	10369	Chemical	Gene	activity|compound|START_ENTITY enhancer|nmod|activity action|nmod|enhancer action|nmod|END_ENTITY	A novel action of stargazin as an enhancer of AMPA receptor activity .
15689545	0	AMPA	92,96	stargazin	66,75	AMPA	stargazin	MESH:D018350	10369	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|nmod|transport	Interaction with the unfolded protein response reveals a role for stargazin in biosynthetic AMPA receptor transport .
17670991	0	AMPA	18,22	stargazin	120,129	AMPA	stargazin	MESH:D018350	10369	Chemical	Gene	protein|compound|START_ENTITY modulator|nsubj|protein modulator|nmod|function function|nmod|END_ENTITY	The transmembrane AMPA receptor regulatory protein gamma 4 is a more effective modulator of AMPA receptor function than stargazin -LRB- gamma_2 -RRB- .
17670991	0	AMPA	92,96	stargazin	120,129	AMPA	stargazin	MESH:D018350	10369	Chemical	Gene	function|compound|START_ENTITY function|nmod|END_ENTITY	The transmembrane AMPA receptor regulatory protein gamma 4 is a more effective modulator of AMPA receptor function than stargazin -LRB- gamma_2 -RRB- .
15788779	0	AMPA	27,31	tumor_necrosis_factor-alpha	74,101	AMPA	tumor necrosis factor-alpha	MESH:D018350	7124	Chemical	Gene	receptor|compound|START_ENTITY receptor|nmod|END_ENTITY	Differential regulation of AMPA receptor and GABA receptor trafficking by tumor_necrosis_factor-alpha .
22675452	0	AMPA_glutamate	39,53	GluA1	14,19	AMPA glutamate	GluA1	null	14799(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Importance of GluA1 subunit-containing AMPA_glutamate receptors for morphine state-dependency .
19166514	0	AMPA_glutamate	42,56	Nuclear_respiratory_factor_1	0,28	AMPA glutamate	Nuclear respiratory factor 1	null	4899	Chemical	Gene	receptor|compound|START_ENTITY receptor|nummod|END_ENTITY	Nuclear_respiratory_factor_1 co-regulates AMPA_glutamate receptor subunit 2 and cytochrome c oxidase : tight coupling of glutamatergic transmission and energy metabolism in neurons .
18562636	0	AMTB	0,4	TRPM8	8,13	AMTB	TRPM8	null	171384(Tax:10116)	Chemical	Gene	START_ENTITY|appos|blocker blocker|compound|END_ENTITY	AMTB , a TRPM8 channel blocker : evidence in rats for activity in overactive_bladder and painful_bladder_syndrome .
17912043	0	AM_251	80,86	CB1	40,43	AM 251	CB1	MESH:C103505	25248(Tax:10116)	Chemical	Gene	antagonist/inverse|dobj|START_ENTITY antagonist/inverse|nsubj|response response|nmod|receptor receptor|compound|END_ENTITY	Acute anorectic response to cannabinoid CB1 receptor antagonist/inverse agonist AM_251 in rats : indirect behavioural mediation .
19443943	0	AM_251	51,57	CB1	27,30	AM 251	CB1	MESH:C103505	25248(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|antagonist antagonist|compound|END_ENTITY	Effects of the cannabinoid CB1 receptor antagonist AM_251 on the reinstatement of nicotine-conditioned place preference by drug priming in rats .
19876791	0	AN-2728	0,7	PDE4	11,15	AN-2728	PDE4	MESH:C543085	5141	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	AN-2728 , a PDE4 inhibitor for the potential topical treatment of psoriasis and atopic_dermatitis .
11805201	8	ANG	1641,1644	MAO	1606,1609	ANG	MAO	null	29253(Tax:10116)	Chemical	Gene	influenced|nmod|START_ENTITY influenced|nmod|END_ENTITY	In vitro MAO activity was not influenced by ANG , enalaprilat , or captopril at concentrations of up to 1 mM .
3028070	0	ANTU	36,40	angiotensin_converting_enzyme	94,123	ANTU	angiotensin converting enzyme	MESH:C005277	24310(Tax:10116)	Chemical	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The effect of alphanapthylthiourea -LRB- ANTU -RRB- - induced acute_injury on lung binding of antibody to angiotensin_converting_enzyme -LRB- ACE -RRB- .
17190766	14	AOM	2098,2101	COX-1	2119,2124	AOM	COX-1	null	26195(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	CONCLUSIONS : Our study suggests that during initiation , AOM inhibits colonic COX-1 expression without affecting COX-2 and dietary curcumin may increase COX-2 expression to compensate AOM-induced reduction of COX-1 expression .
16851631	0	AOT	18,21	CO2	11,14	AOT	CO2	null	717	Chemical	Gene	solution|compound|START_ENTITY END_ENTITY|nmod|solution	Compressed CO2 in AOT reverse micellar solution : effect on stability , percolation , and size .
16952072	0	AP-23573	17,25	mTOR	30,34	AP-23573	mTOR	MESH:C515074	21977(Tax:10090)	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Drug evaluation : AP-23573 -- an mTOR inhibitor for the treatment of cancer .
15256422	0	AP23464	46,53	Bcr-Abl	35,42	AP23464	Bcr-Abl	MESH:C493107	25	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of wild-type and mutant Bcr-Abl by AP23464 , a potent ATP-based oncogenic protein kinase inhibitor : implications for CML .
18451242	0	AP23573	41,48	mammalian_target_of_rapamycin	68,97	AP23573	mammalian target of rapamycin	MESH:C515074	2475	Chemical	Gene	trial|appos|START_ENTITY trial|appos|inhibitor inhibitor|compound|END_ENTITY	A phase 2 clinical trial of deforolimus -LRB- AP23573 , MK-8669 -RRB- , a novel mammalian_target_of_rapamycin inhibitor , in patients with relapsed or refractory hematologic_malignancies .
16373705	0	AP23846	0,7	Src	35,38	AP23846	Src	MESH:C508187	6714	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	AP23846 , a novel and highly potent Src family kinase inhibitor , reduces vascular endothelial growth factor and interleukin-8 expression in human solid tumor cell lines and abrogates downstream angiogenic processes .
26063313	0	AP25	19,23	cyclin_D1	34,43	AP25	cyclin D1	null	595	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|amod|END_ENTITY	Anti-tumor peptide AP25 decreases cyclin_D1 expression and inhibits MGC-803 proliferation via phospho-extracellular signal-regulated kinase - , Src - , c-Jun N-terminal kinase - and phosphoinositide 3-kinase-associated pathways .
22745380	0	APC	27,30	IL-23	36,41	APC	IL-23	null	83430(Tax:10090)	Chemical	Gene	interaction|nmod|START_ENTITY interaction|amod|END_ENTITY	Cell-cell interaction with APC , not IL-23 , is required for naive CD4 cells to acquire pathogenicity during Th17 lineage commitment .
6157628	0	APHZ	51,55	glucose-6-phosphate_dehydrogenase	88,121	APHZ	glucose-6-phosphate dehydrogenase	null	24377(Tax:10116)	Chemical	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of mercury , lead and acetylphenylhydrazine -LRB- APHZ -RRB- on erythrocyte and bone marrow glucose-6-phosphate_dehydrogenase -LRB- E.C. 1.1.1.49 -RRB- .
24129240	0	APR-246	59,66	PRIMA-1	46,53	APR-246	PRIMA-1	MESH:C533410	145270	Chemical	Gene	START_ENTITY|nmod|reactivation reactivation|nmod|END_ENTITY	Variability in functional p53 reactivation by PRIMA-1 -LRB- Met -RRB- / APR-246 in Ewing_sarcoma .
22965953	0	APR-246	74,81	p53	10,13	APR-246	APR	MESH:C533410	5366	Chemical	Gene	study|nmod|START_ENTITY END_ENTITY|dep|study	Targeting p53 in vivo : a first-in-human study with p53-targeting compound APR-246 in refractory hematologic_malignancies and prostate_cancer .
23121409	0	AQX-1125	20,28	SHIP1	47,52	AQX-1125	SHIP1	null	16331(Tax:10090)	Chemical	Gene	START_ENTITY|appos|activator activator|compound|END_ENTITY	Characterization of AQX-1125 , a small-molecule SHIP1 activator : Part 2 .
23121445	0	AQX-1125	20,28	SHIP1	47,52	AQX-1125	SHIP1	null	3635	Chemical	Gene	START_ENTITY|appos|activator activator|compound|END_ENTITY	Characterization of AQX-1125 , a small-molecule SHIP1 activator : Part_1 .
17998876	0	AR-C117977	62,72	MCT-1	44,49	AR-C117977	MCT-1	MESH:C525748	25027(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|appos|END_ENTITY	The specific monocarboxylate_transporter-1 -LRB- MCT-1 -RRB- inhibitor , AR-C117977 , induces donor-specific suppression , reducing acute and chronic allograft rejection in the rat .
19929853	0	AR-C155858	0,10	MCT1	65,69	AR-C155858	MCT1	MESH:C546977	25027(Tax:10116)	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10 .
12588784	0	AR-C69931MX	43,54	P2Y12	25,30	AR-C69931MX	P2Y12	MESH:C117446	64805	Chemical	Gene	receptor|nmod|START_ENTITY receptor|compound|END_ENTITY	Blockade of the platelet P2Y12 receptor by AR-C69931MX sustains coronary artery recanalization and improves the myocardial tissue perfusion in a canine thrombosis model .
19492147	0	AR-H067637	73,83	thrombin	54,62	AR-H067637	thrombin	MESH:C552153	2147	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|effects effects|nmod|END_ENTITY	Biochemical and pharmacological effects of the direct thrombin inhibitor AR-H067637 .
20806126	0	AR-H067637	14,24	thrombin	66,74	AR-H067637	thrombin	MESH:C552153	29251(Tax:10116)	Chemical	Gene	START_ENTITY|appos|metabolite metabolite|nmod|AZD0837 AZD0837|compound|END_ENTITY	Evaluation of AR-H067637 , the active metabolite of the new direct thrombin inhibitor AZD0837 , in models of venous_and_arterial_thrombosis and bleeding in anaesthetised rats .
26613536	0	AR-R17779	54,63	a7_nicotinic_acetylcholine_receptor	84,119	AR-R17779	a7 nicotinic acetylcholine receptor	MESH:C408128	1139	Chemical	Gene	START_ENTITY|appos|agonist agonist|nmod|END_ENTITY	Suppression of abdominal_aortic_aneurysm formation by AR-R17779 , an agonist for the a7_nicotinic_acetylcholine_receptor .
17351396	0	ARC-111	0,7	hypoxia-inducible_factor-1alpha	34,65	ARC-111	hypoxia-inducible factor-1alpha	MESH:C481982	3091	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|accumulation accumulation|amod|END_ENTITY	ARC-111 inhibits hypoxia-mediated hypoxia-inducible_factor-1alpha accumulation .
19637097	0	ARC1779	12,19	von_Willebrand_Factor	58,79	ARC1779	von Willebrand Factor	MESH:C526287	7450	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|function function|compound|END_ENTITY	The aptamer ARC1779 is a potent and specific inhibitor of von_Willebrand_Factor mediated ex vivo platelet function in acute_myocardial_infarction .
22740102	0	ARC1779	39,46	von_Willebrand_factor	57,78	ARC1779	von Willebrand factor	MESH:C526287	7450	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|compound|END_ENTITY	The anti-von_Willebrand_factor aptamer ARC1779 increases von_Willebrand_factor levels and platelet counts in patients with type_2B_von_Willebrand_disease .
8964798	0	ARL_17477	0,9	neuronal_NOS	34,46	ARL 17477	neuronal NOS	MESH:C102136	24598(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	ARL_17477 , a potent and selective neuronal_NOS inhibitor decreases infarct volume after transient middle_cerebral_artery_occlusion in rats .
10899290	0	ARL_17477	0,9	nitric_oxide_synthase	23,44	ARL 17477	nitric oxide synthase	MESH:C102136	4842	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	ARL_17477 , a selective nitric_oxide_synthase inhibitor , with neuroprotective effects in animal models of global and focal cerebral_ischaemia .
21187062	0	ARP101	0,6	MMP-2	20,25	ARP101	MMP-2	null	17390(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	ARP101 , a selective MMP-2 inhibitor , induces autophagy-associated cell death in cancer cells .
20506063	0	ARQ-197	0,7	c-Met	45,50	ARQ-197	c-Met	MESH:C551661	4233	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	ARQ-197 , an oral small-molecule inhibitor of c-Met for the treatment of solid_tumors .
25483224	0	ARQ197	68,74	c-Met	28,33	ARQ197	c-Met	MESH:C551661	4233	Chemical	Gene	Activity|appos|START_ENTITY Activity|nmod|END_ENTITY	Synergistic Activity of the c-Met and Tubulin Inhibitor Tivantinib -LRB- ARQ197 -RRB- with Pemetrexed in Mesothelioma Cells .
21383285	0	ARQ_197	45,52	c-MET	29,34	ARQ 197	c-MET	MESH:C551661	4233	Chemical	Gene	START_ENTITY|nsubj|trial trial|nmod|inhibitor inhibitor|amod|END_ENTITY	Phase I trial of a selective c-MET inhibitor ARQ_197 incorporating proof of mechanism pharmacodynamic studies .
25480830	0	ARRY-614	24,32	p38	36,39	ARRY-614	p38	null	1432	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|amod|END_ENTITY	A Phase I Study of Oral ARRY-614 , a p38 MAPK/Tie2 Dual Inhibitor , in Patients with Low_or_Intermediate-1_Risk_Myelodysplastic_Syndromes .
26381508	0	AS-703026	0,9	TNFa	31,35	AS-703026	TNFa	MESH:C550600	21926(Tax:10090)	Chemical	Gene	Production|compound|START_ENTITY Production|compound|END_ENTITY	AS-703026 Inhibits LPS-Induced TNFa Production through MEK/ERK Dependent and Independent Mechanisms .
18493250	0	AS111793	32,40	MMP-12	14,20	AS111793	MMP-12	null	17381(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	The selective MMP-12 inhibitor , AS111793 reduces airway inflammation in mice exposed to cigarette smoke .
21114601	0	AS1535907	43,52	GPR119	27,33	AS1535907	GPR119	MESH:C554427	236781(Tax:10090)	Chemical	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	The role of small molecule GPR119 agonist , AS1535907 , in glucose-stimulated insulin secretion and pancreatic b-cell function .
17646153	0	AS1643	83,89	low-molecular-weight_glutenin_subunit	12,49	AS1643	low-molecular-weight glutenin subunit	null	543091(Tax:4565)	Chemical	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	-LSB- Cloning of low-molecular-weight_glutenin_subunit gene from Sichuan wheat landrace AS1643 and its secondary structure prediction -RSB- .
20816753	0	AS1907417	0,9	GPR119	19,25	AS1907417	GPR119	MESH:C553501	236781(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	AS1907417 , a novel GPR119 agonist , as an insulinotropic and b-cell preservative agent for the treatment of type 2 diabetes .
23792539	0	AS2586114	11,20	soluble_epoxide_hydrolase	24,49	AS2586114	soluble epoxide hydrolase	null	13850(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effects of AS2586114 , a soluble_epoxide_hydrolase inhibitor , on hyperlocomotion and prepulse inhibition_deficits in mice after administration of phencyclidine .
18026128	0	AS601245	0,8	JNK	39,42	AS601245	JNK	MESH:C489138	5599	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|appos|END_ENTITY	AS601245 , a c-Jun NH2-terminal kinase -LRB- JNK -RRB- inhibitor , reduces axon/dendrite _ damage and cognitive_deficits after global_cerebral_ischaemia in gerbils .
14988419	0	AS601245	0,8	c-Jun_NH2-terminal_protein_kinase	99,132	AS601245	c-Jun NH2-terminal protein kinase	MESH:C489138	116554(Tax:10116)	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	AS601245 -LRB- 1,3-benzothiazol-2-yl -LRB- 2 - -LSB- -LSB- 2 - -LRB- 3-pyridinyl -RRB- ethyl -RSB- amino -RSB- -4 pyrimidinyl -RRB- acetonitrile -RRB- : a c-Jun_NH2-terminal_protein_kinase inhibitor with neuroprotective properties .
14603259	0	AS602868	0,8	IKK2	41,45	AS602868	IKK2	MESH:C519899	3551	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	AS602868 , a pharmacological inhibitor of IKK2 , reveals the apoptotic potential of TNF-alpha in Jurkat leukemic cells .
17330097	0	AS602868	0,8	IKK2	30,34	AS602868	IKK2	MESH:C519899	3551	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	AS602868 , a dual inhibitor of IKK2 and FLT3 to target AML cells .
21799925	0	AS602868	64,72	IKK2	77,81	AS602868	IKK2	MESH:C519899	3551	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Inhibition of IGF-1 signalling enhances the apoptotic effect of AS602868 , an IKK2 inhibitor , in multiple myeloma cell lines .
19195485	0	ASB16165	0,8	IFN-gamma	87,96	ASB16165	IFN-gamma	MESH:C539237	15978(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|production production|amod|END_ENTITY	ASB16165 , a novel inhibitor for phosphodiesterase_7A -LRB- PDE7A -RRB- , suppresses IL-12-induced IFN-gamma production by mouse activated T lymphocytes .
19195485	0	ASB16165	0,8	phosphodiesterase_7A	32,52	ASB16165	phosphodiesterase 7A	MESH:C539237	18583(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	ASB16165 , a novel inhibitor for phosphodiesterase_7A -LRB- PDE7A -RRB- , suppresses IL-12-induced IFN-gamma production by mouse activated T lymphocytes .
19379723	0	ASB16165	0,8	phosphodiesterase_7A	12,32	ASB16165	phosphodiesterase 7A	MESH:C539237	18583(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	ASB16165 , a phosphodiesterase_7A inhibitor , reduces cutaneous TNF-alpha level and ameliorates skin_edema in phorbol_ester 12-O-tetradecanoylphorbol-13-acetate-induced skin_inflammation model in mice .
24603303	0	ASC_amino-acid	0,14	ASCT2	30,35	ASC amino-acid	ASCT2	null	6510	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	ASC_amino-acid transporter 2 -LRB- ASCT2 -RRB- as a novel prognostic marker in non-small_cell_lung_cancer .
10070056	9	ASN	1357,1360	ODC	1340,1343	ASN	ODC	CHEBI:17196	24609(Tax:10116)	Chemical	Gene	that|nmod|START_ENTITY increased|nmod|that increased|dobj|expression expression|nmod|END_ENTITY	The addition of ASN did not further increase the expression of the protooncogenes , but the combination of EGF and ASN further increased the expression of ODC over that of ASN alone .
22542656	0	ASP2535	49,56	GlyT1	31,36	ASP2535	GlyT1	MESH:C575159	116509(Tax:10116)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	A novel glycine_transporter-1 -LRB- GlyT1 -RRB- inhibitor , ASP2535 -LRB- 4 - -LSB- 3-isopropyl-5 - -LRB- 6-phenyl-3-pyridyl -RRB- -4 H-1 ,2,4 - triazol-4-yl -RSB- -2,1,3 - benzoxadiazole -RRB- , improves cognition in animal models of cognitive_impairment in schizophrenia and Alzheimer 's _ disease .
22542656	0	ASP2535	49,56	glycine_transporter-1	8,29	ASP2535	glycine transporter-1	MESH:C575159	116509(Tax:10116)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	A novel glycine_transporter-1 -LRB- GlyT1 -RRB- inhibitor , ASP2535 -LRB- 4 - -LSB- 3-isopropyl-5 - -LRB- 6-phenyl-3-pyridyl -RRB- -4 H-1 ,2,4 - triazol-4-yl -RSB- -2,1,3 - benzoxadiazole -RRB- , improves cognition in animal models of cognitive_impairment in schizophrenia and Alzheimer 's _ disease .
19238312	0	ASP4000	0,7	dipeptidyl_peptidase_4	24,46	ASP4000	dipeptidyl peptidase 4	MESH:C532179	25253(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	ASP4000 , a slow-binding dipeptidyl_peptidase_4 inhibitor , has antihyperglycemic activity of long duration in Zucker fatty rats .
24291101	0	ASP7663	40,47	TRPA1	17,22	ASP7663	TRPA1	null	312896(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|agonist agonist|nummod|END_ENTITY	Effects of novel TRPA1 receptor agonist ASP7663 in models of drug-induced constipation and visceral_pain .
18398600	0	ASP8497	27,34	dipeptidyl_peptidase-IV	72,95	ASP8497	dipeptidyl peptidase-IV	MESH:C530746	13482(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Pharmacological profile of ASP8497 , a novel , selective , and competitive dipeptidyl_peptidase-IV inhibitor , in vitro and in vivo .
18468582	0	ASP8497	0,7	dipeptidyl_peptidase-IV	45,68	ASP8497	dipeptidyl peptidase-IV	MESH:C530746	13482(Tax:10090)	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|amod|END_ENTITY	ASP8497 is a novel selective and competitive dipeptidyl_peptidase-IV inhibitor with antihyperglycemic activity .
19766107	0	ASP8497	49,56	dipeptidyl_peptidase-IV	15,38	ASP8497	dipeptidyl peptidase-IV	MESH:C530746	25253(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Effects of the dipeptidyl_peptidase-IV inhibitor ASP8497 on glucose tolerance in animal models of secondary failure .
25891879	0	AST	0,3	Nox4	93,97	AST	Nox4	null	50507	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|suppressing suppressing|dobj|expression expression|amod|END_ENTITY	AST inhibits H2O2-induced human umbilical vein endothelial cell apoptosis by suppressing Nox4 expression through the TGF-b1 / Smad2 pathway .
24747122	0	AST1306	0,7	EGFR	18,22	AST1306	EGFR	MESH:C568037	1956	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	AST1306 , a potent EGFR inhibitor , antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistance .
11776321	0	AT-1459	31,38	thrombin	56,64	AT-1459	thrombin	MESH:C459443	29251(Tax:10116)	Chemical	Gene	efficacy|nmod|START_ENTITY efficacy|appos|inhibitor inhibitor|compound|END_ENTITY	The antithrombotic efficacy of AT-1459 , a novel , direct thrombin inhibitor , in rat models of venous and arterial_thrombosis .
25168470	0	AT-406	0,6	IAP	11,14	AT-406	IAP	MESH:C559144	248	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	AT-406 , an IAP inhibitor , activates apoptosis and induces radiosensitization of normoxic and hypoxic cervical_cancer cells .
21538821	0	AT13387	29,36	HSP90	41,46	AT13387	HSP90	MESH:C552103	3320	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Initial testing -LRB- Stage 1 -RRB- of AT13387 , an HSP90 inhibitor , by the pediatric preclinical testing program .
22714264	0	AT13387	21,28	HSP90	4,9	AT13387	HSP90	MESH:C552103	3320	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	The HSP90 inhibitor , AT13387 , is effective against imatinib-sensitive and - resistant gastrointestinal stromal_tumor models .
25336693	0	AT13387	99,106	HSP90	82,87	AT13387	HSP90	MESH:C552103	3320	Chemical	Gene	Inhibitor|appos|START_ENTITY Inhibitor|compound|END_ENTITY	First-in-Human Phase I Dose Escalation Study of a Second-Generation Non-Ansamycin HSP90 Inhibitor , AT13387 , in Patients with Advanced_Solid_Tumors .
25349308	0	AT13387	23,30	HSP90	14,19	AT13387	HSP90	MESH:C552103	3320	Chemical	Gene	delays|nummod|START_ENTITY END_ENTITY|nmod|delays	Inhibition of HSP90 by AT13387 delays the emergence of resistance to BRAF inhibitors and overcomes resistance to dual BRAF and MEK inhibition in melanoma models .
20662534	0	AT13387	117,124	Hsp90	172,177	AT13387	Hsp90	MESH:C552103	3320	Chemical	Gene	methanone|appos|START_ENTITY methanone|appos|inhibitor inhibitor|nmod|END_ENTITY	Discovery of -LRB- 2,4-dihydroxy-5-isopropylphenyl -RRB- - -LSB- 5 - -LRB- 4-methylpiperazin-1-ylmethyl -RRB- -1,3 - dihydroisoindol-2-yl -RSB- methanone -LRB- AT13387 -RRB- , a novel inhibitor of the molecular chaperone Hsp90 by fragment based drug design .
22181674	0	AT13387	37,44	heat_shock_protein_90	4,25	AT13387	heat shock protein 90	MESH:C552103	3320	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	The heat_shock_protein_90 inhibitor , AT13387 , displays a long duration of action in vitro and in vivo in non-small cell lung_cancer .
20423992	0	AT7867	0,6	AKT	41,44	AT7867	AKT	MESH:C551535	207	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	AT7867 is a potent and oral inhibitor of AKT and p70_S6_kinase that induces pharmacodynamic changes and inhibits human tumor xenograft growth .
20423992	2	AT7867	453,459	AKT	500,503	AT7867	AKT	MESH:C551535	207	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|nmod|p70_S6_kinase p70_S6_kinase|dep|both both|dep|END_ENTITY	Fragment-based lead discovery , combined with structure-based drug design , has recently identified AT7867 as a novel and potent inhibitor of both AKT and the downstream kinase p70_S6_kinase -LRB- p70S6K -RRB- and also of protein kinase A .
16614734	0	ATC0175	0,7	melanin-concentrating_hormone_receptor_1	26,66	ATC0175	melanin-concentrating hormone receptor 1	MESH:C501654	2847	Chemical	Gene	START_ENTITY|dep|antagonist antagonist|amod|END_ENTITY	ATC0175 : an orally active melanin-concentrating_hormone_receptor_1 antagonist for the potential treatment of depression and anxiety .
16760673	0	ATM	14,17	H2AX	30,34	ATM	H2AX	null	3014	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Activation of ATM and histone H2AX phosphorylation induced by mitoxantrone but not by topotecan is prevented by the antioxidant N-acetyl-L-cysteine .
16705310	0	ATN-161	44,51	a_beta	70,76	ATN-161	a beta	null	351	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Phase 1 trial of the antiangiogenic peptide ATN-161 -LRB- Ac-PHSCN-NH -LRB- 2 -RRB- -RRB- , a_beta integrin antagonist , in patients with solid tumours .
11787058	0	ATP	0,3	11beta-hydroxysteroid_dehydrogenase_type_2	31,73	ATP	11beta-hydroxysteroid dehydrogenase type 2	MESH:D000255	3291	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|amod|END_ENTITY	ATP stimulates human placental 11beta-hydroxysteroid_dehydrogenase_type_2 activity by a novel mechanism independent of phosphorylation .
24893149	0	ATP	0,3	5-lipoxygenase	39,53	ATP	5-lipoxygenase	MESH:D000255	240	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|mechanism mechanism|amod|END_ENTITY	ATP allosterically activates the human 5-lipoxygenase molecular mechanism of arachidonic_acid and 5 -LRB- S -RRB- - hydroperoxy-6 -LRB- E -RRB- ,8 -LRB- Z -RRB- ,11 -LRB- Z -RRB- ,14 -LRB- Z -RRB- - eicosatetraenoic_acid .
7577949	0	ATP	41,44	5-lipoxygenase	68,82	ATP	5-lipoxygenase	MESH:D000255	240	Chemical	Gene	sites|compound|START_ENTITY sites|nmod|END_ENTITY	Characterization of the arachidonate and ATP binding sites of human 5-lipoxygenase using photoaffinity labeling and enzyme immobilization .
10207018	0	ATP	64,67	70-kDa_peroxisomal_membrane_protein	24,59	ATP	70-kDa peroxisomal membrane protein	MESH:D000255	25270(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|appos|transporter	Characterization of the 70-kDa_peroxisomal_membrane_protein , an ATP binding cassette transporter .
22257947	0	ATP	116,119	ABCA12	138,144	ATP	ABCA12	MESH:D000255	26154	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Non-bullous congentital ichthyosiform erythroderma associated with homozygosity for a novel missense mutation in an ATP binding domain of ABCA12 .
12888572	0	ATP	76,79	ABCA4	111,116	ATP	ABCA4	MESH:D000255	24	Chemical	Gene	ABCR|compound|START_ENTITY ABCR|appos|END_ENTITY	Functional interaction between the two halves of the photoreceptor-specific ATP binding cassette protein ABCR -LRB- ABCA4 -RRB- .
23144455	0	ATP	95,98	ABCA4	135,140	ATP	ABCA4	MESH:D000255	24	Chemical	Gene	cassette|compound|START_ENTITY cassette|amod|END_ENTITY	Retinoid binding properties of nucleotide binding domain 1 of the Stargardt_disease-associated ATP binding cassette -LRB- ABC -RRB- transporter , ABCA4 .
26092729	0	ATP	36,39	ABCA4	66,71	ATP	ABCA4	MESH:D000255	24	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Rescuing trafficking mutants of the ATP binding cassette protein , ABCA4 , with small molecule correctors as a treatment for Stargardt_eye_disease .
22884976	5	ATP	816,819	ABCB10	733,739	ATP	ABCB10	MESH:D000255	23456	Chemical	Gene	domain|compound|START_ENTITY located|nmod|domain located|nsubjpass|END_ENTITY	ABCB10 is located in the inner mitochondrial membrane forming homodimers , with the ATP binding domain facing the mitochondrial matrix .
26053025	0	ATP	0,3	ABCB10	41,47	ATP	ABCB10	MESH:D000255	23456	Chemical	Gene	Binding|compound|START_ENTITY Binding|nmod|END_ENTITY	ATP Binding and Hydrolysis Properties of ABCB10 and Their Regulation by Glutathione .
11955620	0	ATP	73,76	ABCB6	113,118	ATP	ABCB6	MESH:D000255	10058	Chemical	Gene	cassette|compound|START_ENTITY containing|nmod|cassette containing|dep|END_ENTITY	Isolation of a genomic clone containing the promoter region of the human ATP binding cassette -LRB- ABC -RRB- transporter , ABCB6 .
22761424	0	ATP	82,85	ABCB6	115,120	ATP	ABCB6	MESH:D000255	74104(Tax:10090)	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Polycyclic_aromatic_hydrocarbons -LRB- PAHs -RRB- mediate transcriptional activation of the ATP binding cassette transporter ABCB6 gene via the aryl_hydrocarbon_receptor -LRB- AhR -RRB- .
10748049	0	ATP	30,33	ABCB9	20,25	ATP	ABCB9	MESH:D000255	23457	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	Characterization of ABCB9 , an ATP binding cassette protein associated with lysosomes .
15863492	0	ATP	73,76	ABCB9	116,121	ATP	ABCB9	MESH:D000255	23457	Chemical	Gene	TAP-like|compound|START_ENTITY TAP-like|appos|END_ENTITY	Selective and ATP-dependent translocation of peptides by the homodimeric ATP binding cassette transporter TAP-like -LRB- ABCB9 -RRB- .
10075733	0	ATP	19,22	ABCR	64,68	ATP	ABCR	MESH:D000255	24	Chemical	Gene	hydrolysis|compound|START_ENTITY stimulates|dobj|hydrolysis stimulates|nmod|END_ENTITY	Retinal stimulates ATP hydrolysis by purified and reconstituted ABCR , the photoreceptor-specific ATP-binding cassette transporter responsible for Stargardt_disease .
10874631	0	ATP	34,37	ABCR	64,68	ATP	ABCR	MESH:D000255	24	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mutations of the retinal specific ATP binding transporter gene -LRB- ABCR -RRB- in a single family segregating both autosomal_recessive_retinitis_pigmentosa_RP19 and Stargardt_disease : evidence of clinical heterogeneity at this locus .
9503029	0	ATP	54,57	ABCR	84,88	ATP	ABCR	MESH:D000255	24	Chemical	Gene	gene|compound|START_ENTITY structure|nmod|gene structure|appos|END_ENTITY	Complete exon-intron structure of the retina-specific ATP binding transporter gene -LRB- ABCR -RRB- allows the identification of novel mutations underlying Stargardt_disease .
11408438	0	ATP	30,33	AMPD1	48,53	ATP	AMPD1	MESH:D000255	270	Chemical	Gene	catabolism|compound|START_ENTITY catabolism|nmod|END_ENTITY	Regulation of skeletal muscle ATP catabolism by AMPD1 genotype during sprint exercise in asymptomatic subjects .
24496445	0	ATP	41,44	AMPK	22,26	ATP	AMPK	MESH:D000255	5562	Chemical	Gene	activation|nmod|START_ENTITY END_ENTITY|acl|activation	Purinergic control of AMPK activation by ATP released through connexin_43 hemichannels - pivotal roles in hemichannel-mediated cell injury .
12645530	0	ATP	0,3	ATM	45,48	ATP	ATM	MESH:D000255	472	Chemical	Gene	activates|nsubj|START_ENTITY activates|dep|END_ENTITY	ATP activates ataxia-telangiectasia_mutated -LRB- ATM -RRB- in vitro .
11259409	2	ATP	335,338	ATP	359,362	ATP	JNK	MESH:D000255	5599	Chemical	Gene	START_ENTITY|appos|form form|nmod|END_ENTITY	Using this approach , we altered the ATP-binding site on JNK and identified N -LRB- 6 -RRB- - -LRB- 2-phenythyl -RRB- - ATP , a modified form of ATP that exhibits high specificity and affinity for the modified , but not the wild type form , of JNK .
9284928	0	ATP	110,113	ATP5A	143,148	ATP	ATP5A	MESH:D000255	498	Chemical	Gene	START_ENTITY|dobj|maps maps|appos|END_ENTITY	Comparative genomic hybridization analysis of Y79 and FISH mapping indicate the amplified human mitochondrial ATP synthase alpha-subunit gene -LRB- ATP5A -RRB- maps to chromosome 18q12 -- > q21 .
10664465	0	ATP	0,3	ATPase	37,43	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	synthesis|compound|START_ENTITY C|nsubj|synthesis C|nmod|END_ENTITY	ATP synthesis at 100 degrees C by an ATPase purified from the hyperthermophilic archaeon Pyrodictium abyssi .
10696091	0	ATP	111,114	ATPase	62,68	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	stress|parataxis|START_ENTITY stress|nmod|release release|nmod|END_ENTITY	Effect of shear stress on the release of soluble ecto-enzymes ATPase and 5 ' - nucleotidase along with endogenous ATP from vascular endothelial cells .
11163220	0	ATP	53,56	ATPase	41,47	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	binding|compound|START_ENTITY change|nmod|binding change|nmod|END_ENTITY	A major conformational change in p97 AAA ATPase upon ATP binding .
11772399	0	ATP	35,38	ATPase	77,83	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	hydrolysis|nmod|START_ENTITY uncouples|dobj|hydrolysis uncouples|nmod|accumulation accumulation|nmod|+ +|dep|END_ENTITY	Sarcolipin uncouples hydrolysis of ATP from accumulation of Ca2 + by the Ca2 + - ATPase of skeletal-muscle sarcoplasmic reticulum .
12234183	0	ATP	99,102	ATPase	66,72	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	Fe|dep|START_ENTITY Fe|dep|oxidation oxidation|nmod|Mg Mg|compound|END_ENTITY	Fe -LRB- 2 + -RRB- - catalyzed oxidation and cleavage of sarcoplasmic reticulum ATPase reveals Mg -LRB- 2 + -RRB- and Mg -LRB- 2 + -RRB- - ATP sites .
12414670	0	ATP	65,68	ATPase	93,99	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	synthesis|compound|START_ENTITY synthesis|nmod|END_ENTITY	Cooperative setting for long-range linkage of Ca -LRB- 2 + -RRB- binding and ATP synthesis in the Ca -LRB- 2 + -RRB- ATPase .
126582	0	ATP	77,80	ATPase	0,6	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	concentration|compound|START_ENTITY dependence|nmod|concentration activity|dep|dependence activity|amod|END_ENTITY	ATPase activity and light scattering of acto-heavy meromyosin : dependence on ATP concentration and on ionic strength .
131585	0	ATP	67,70	ATPase	93,99	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	hydrolysis|compound|START_ENTITY reaction|nmod|hydrolysis coupled|nmod|reaction coupled|nmod|END_ENTITY	-LSB- Proton transfer from water to octane coupled with the reaction of ATP hydrolysis by soluble ATPase from chloroplasts -RSB- .
141305	0	ATP	40,43	ATPase	66,72	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	kinetics|nmod|START_ENTITY Study|nmod|kinetics hydrolysis|nsubj|Study hydrolysis|nmod|END_ENTITY	-LSB- Study of the kinetics and mechanism of ATP hydrolysis by soluble ATPase of the chloroplasts -LRB- CFl -RRB- in the presence of Mg2 + ions -RSB- .
15788490	0	ATP	71,74	ATPase	109,115	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	alter|nsubj|START_ENTITY alter|parataxis|transport transport|nsubj|END_ENTITY	Kinetic characterization of tetrapropylammonium inhibition reveals how ATP and Pi alter access to the Na + - K + - ATPase transport site .
16405964	0	ATP	54,57	ATPase	18,24	ATP	ATPase	MESH:D000255	3654511(Tax:562)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Inhibition of the ATPase activity of Escherichia_coli ATP synthase by magnesium_fluoride .
16660692	8	ATP	1763,1766	ATPase	1812,1818	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	content|compound|START_ENTITY lowered|nsubjpass|content lowered|advmod|slightly slightly|advcl|inhibited inhibited|nsubj|END_ENTITY	However , the rapid -LRB- less than 5 minutes -RRB- inhibition of absorption is caused by direct inhibition of the ATPase rather than a reduced ATP supply because the ATP content is lowered only slightly whereas the ATPase is inhibited dramatically in that time .
1697910	0	ATP	100,103	ATPase	14,20	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	analog|nmod|START_ENTITY END_ENTITY|nmod|analog	Activation of ATPase activity of simian_virus_40 large T antigen by the covalent affinity analog of ATP , fluorosulfonylbenzoyl_5 ' - adenosine .
17157262	0	ATP	45,48	ATPase	23,29	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	complexes|nmod|START_ENTITY complexes|amod|END_ENTITY	Structures of the Ca2 + - ATPase complexes with ATP , AMPPCP and AMPPNP .
1826661	0	ATP	61,64	ATPase	108,114	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	hydrolysis|compound|START_ENTITY stimulate|dobj|hydrolysis stimulate|parataxis|glutathione glutathione|dobj|END_ENTITY	The anionic conjugates of bilirubin and bile_acids stimulate ATP hydrolysis by S - -LRB- dinitrophenyl -RRB- glutathione ATPase of human erythrocyte .
1827256	0	ATP	80,83	ATPase	40,46	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	catalyzes|dobj|START_ENTITY END_ENTITY|acl:relcl|catalyzes	Purification and characterization of an ATPase from human liver which catalyzes ATP hydrolysis in the presence of the conjugates of bilirubin_bile_acids and glutathione .
1831462	0	ATP	12,15	ATPase	50,56	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	release|compound|START_ENTITY release|amod|binding binding|nmod|cycle cycle|amod|END_ENTITY	Kinetics of ATP release and Pi binding during the ATPase cycle of lethocerus flight muscle fibres , using phosphate-water oxygen exchange .
19375450	0	ATP	50,53	ATPase	14,20	ATP	ATPase	MESH:D000255	3654511(Tax:562)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Inhibition of ATPase activity of Escherichia_coli ATP synthase by polyphenols .
19925794	0	ATP	82,85	ATPase	24,30	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	CF1CFo|compound|START_ENTITY activity|nmod|CF1CFo activity|compound|END_ENTITY	Singlet oxygen inhibits ATPase and proton translocation activity of the thylakoid ATP synthase CF1CFo .
21212073	0	ATP	48,51	ATPase	93,99	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	analogue|compound|START_ENTITY Synthesis|nmod|analogue Synthesis|nmod|END_ENTITY	Synthesis of a novel fluorescent non-nucleotide ATP analogue and its interaction with myosin ATPase .
2136738	0	ATP	31,34	ATPase	69,75	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	dependence|nmod|START_ENTITY dependence|amod|binding binding|nmod|END_ENTITY	pH and magnesium dependence of ATP binding to sarcoplasmic reticulum ATPase .
2147416	0	ATP	16,19	ATPase	73,79	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	function|compound|START_ENTITY Modification|nmod|function Modification|dep|END_ENTITY	Modification of ATP regulatory function in sarcoplasmic reticulum Ca2 -LRB- + -RRB- - ATPase by hydrophobic molecules .
2148693	0	ATP	37,40	ATPase	94,100	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	adduct|nmod|START_ENTITY Reaction|nmod|adduct Reaction|nmod|site site|nmod|END_ENTITY	Reaction of a carbodiimide adduct of ATP at the active site of sarcoplasmic reticulum calcium ATPase .
21510843	0	ATP	0,3	ATPase	96,102	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	crucial|nsubj|START_ENTITY crucial|nmod|coupling coupling|nmod|activities activities|compound|END_ENTITY	ATP binding to the subunit of thermophilic ATP synthase is crucial for efficient coupling of ATPase and H + pump activities .
21510843	0	ATP	46,49	ATPase	96,102	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	synthase|compound|START_ENTITY subunit|nmod|synthase binding|nmod|subunit ATP|amod|binding crucial|nsubj|ATP crucial|nmod|coupling coupling|nmod|activities activities|compound|END_ENTITY	ATP binding to the subunit of thermophilic ATP synthase is crucial for efficient coupling of ATPase and H + pump activities .
240443	0	ATP	104,107	ATPase	45,51	ATP	ATPase	MESH:D000255	3654511(Tax:562)	Chemical	Gene	hydrolysis|compound|START_ENTITY specificity|nmod|hydrolysis mutants|nmod|specificity mutants|nsubj|Isolation Isolation|nmod|END_ENTITY	Isolation and properties of Escherichia_coli ATPase mutants with altered divalent metal specificity for ATP hydrolysis .
24253837	0	ATP	56,59	ATPase	15,21	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	concentration|compound|START_ENTITY dependent|nmod|concentration dependent|nsubj|Stimulation Stimulation|nmod|activity activity|amod|END_ENTITY	Stimulation of ATPase activity by auxin is dependent on ATP concentration .
24302441	0	ATP	58,61	ATPase	108,114	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	START_ENTITY|dobj|ratios ratios|nmod|END_ENTITY	Ca -LRB- 2 + -RRB- / H _ -LRB- + -RRB- exchange , lumenal Ca -LRB- 2 + -RRB- release and Ca _ -LRB- 2 + -RRB- / ATP coupling ratios in the sarcoplasmic reticulum ATPase .
2454921	0	ATP	130,133	ATPase	92,98	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	hydrolysis|nsubj|START_ENTITY END_ENTITY|parataxis|hydrolysis	Partial resolution and reconstitution of the subunits of the clathrin-coated vesicle proton ATPase responsible for Ca2 + - activated ATP hydrolysis .
24838490	0	ATP	67,70	ATPase	0,6	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	based|nmod|START_ENTITY inhibitor|acl|based inhibitor|amod|END_ENTITY	ATPase inhibitor based luciferase assay for prolonged and enhanced ATP pool measurement as an efficient fish freshness indicator .
2521826	0	ATP	124,127	ATPase	19,25	ATP	ATPase	MESH:D000255	3654511(Tax:562)	Chemical	Gene	synthase|compound|START_ENTITY Halobacterium_saccharovorum|nmod|synthase Halobacterium_saccharovorum|nsubj|comparison comparison|nmod|END_ENTITY	A comparison of an ATPase from the archaebacterium Halobacterium_saccharovorum with the F1 moiety from the Escherichia_coli ATP synthase .
2524480	0	ATP	66,69	ATPase	46,52	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	hydrolysis|compound|START_ENTITY coupled|nmod|hydrolysis END_ENTITY|acl|coupled	Dynamic conformational changes of 21 S dynein ATPase coupled with ATP hydrolysis revealed by proteolytic digestion .
2551380	0	ATP	23,26	ATPase	164,170	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	binding|nmod|START_ENTITY binding|dep|END_ENTITY	Competitive binding of ATP and the fluorescent substrate analogue 2 ' ,3 ' - O - -LRB- 2,4,6-trinitrophenylcyclohexadienylidine -RRB- adenosine_5 ' - triphosphate to the gastric H + , K + - ATPase : evidence for two classes of nucleotide sites .
25713065	0	ATP	26,29	ATPase	73,79	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	Direction|compound|START_ENTITY Rotation|nmod|Direction Rotation|nmod|END_ENTITY	Fo-driven Rotation in the ATP Synthase Direction against the Force of F1 ATPase in the FoF1 ATP Synthase .
25713065	0	ATP	92,95	ATPase	73,79	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	Synthase|compound|START_ENTITY END_ENTITY|nmod|Synthase	Fo-driven Rotation in the ATP Synthase Direction against the Force of F1 ATPase in the FoF1 ATP Synthase .
26140992	0	ATP	68,71	ATPase	114,120	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	synthases|nsubj|START_ENTITY synthases|nmod|mechanisms mechanisms|nmod|inhibition inhibition|compound|END_ENTITY	Linking structural features from mitochondrial and bacterial F-type ATP synthases to their distinct mechanisms of ATPase inhibition .
26465836	0	ATP	0,3	ATPase	95,101	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	underlie|nsubj|START_ENTITY underlie|dobj|function function|amod|END_ENTITY	ATP binding to neighbouring subunits and intersubunit allosteric coupling underlie proteasomal ATPase function .
2900778	0	ATP	129,132	ATPase	62,68	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	hydrolysis|compound|START_ENTITY kinetics|nmod|hydrolysis revealed|nmod|kinetics revealed|nsubj|sites sites|nmod|END_ENTITY	Three adenine_nucleotide binding sites in F1-F0 mitochondrial ATPase as revealed by presteady-state and steady-state kinetics of ATP hydrolysis .
2949777	0	ATP	20,23	ATPase	58,64	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	site|compound|START_ENTITY position|nmod|site position|dep|END_ENTITY	The position of the ATP binding site on the -LRB- Ca2 + + Mg2 + -RRB- - ATPase .
2963588	0	ATP	23,26	ATPase	72,78	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|calcium calcium|nmod|END_ENTITY	Accelerating effect of ATP on calcium binding to sarcoplasmic reticulum ATPase .
2970458	0	ATP	0,3	ATPase	46,52	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	regulation|compound|START_ENTITY regulation|dep|END_ENTITY	ATP regulation of sarcoplasmic reticulum Ca2 + - ATPase .
2970458	1	ATP	65,68	ATPase	149,155	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	Metal-free|dobj|START_ENTITY Metal-free|nmod|site site|nmod|END_ENTITY	Metal-free ATP and 8-bromo-ATP bind with high affinity to the catalytic site of phosphorylated ATPase and accelerate dephosphorylation .
31147	0	ATP	28,31	ATPase	50,56	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	Hydrolysis|nmod|START_ENTITY Hydrolysis|nmod|END_ENTITY	Hydrolysis and synthesis of ATP by membrane-bound ATPase from a motile Streptococcus .
3158649	0	ATP	25,28	ATPase	134,140	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	synthesis|compound|START_ENTITY kinetics|nmod|synthesis catalyzed|nsubj|kinetics catalyzed|nmod|END_ENTITY	Steady state kinetics of ATP synthesis and hydrolysis coupled calcium transport catalyzed by the reconstituted sarcoplasmic reticulum ATPase .
4252323	0	ATP	11,14	ATPase	71,77	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	Studies|nmod|START_ENTITY hydrolysis|nsubj|Studies hydrolysis|nmod|medium medium|nmod|demonstration demonstration|nmod|activity activity|compound|END_ENTITY	Studies on ATP hydrolysis in medium for histochemical demonstration of ATPase activity .
44347	2	ATP	75,78	ATPase	128,134	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	Effect of extramitochondrial ATP and pH on uncoupler-sensitivity of mitochondrial ATPase activity .
6111563	0	ATP	37,40	ATPase	71,77	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	Ratio|nmod|START_ENTITY Ratio|nmod|END_ENTITY	Ratio of hydrolysis and synthesis of ATP by the sarcoplasmic reticulum ATPase in the absence of a Ca2 + concentration gradient .
6114755	0	ATP	0,3	ATPase	29,35	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	synthesis|compound|START_ENTITY synthesis|dep|END_ENTITY	ATP synthesis by Ca2 + + Mg2 + - ATPase in detergent solution at constant Ca2 + levels .
6129563	0	ATP	74,77	ATPase	28,34	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	phen|dep|START_ENTITY Inhibition|dep|phen Inhibition|dep|END_ENTITY	Inhibition of the Ca2 + - Mg2 + ATPase of sarcoplasmic reticulum by Co - -LRB- phen -RRB- - ATP .
6146631	0	ATP	60,63	ATPase	86,92	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	hydrolysis|nmod|START_ENTITY coats|acl|hydrolysis Dissociation|nmod|coats Dissociation|dep|role role|nmod|END_ENTITY	Dissociation of clathrin coats coupled to the hydrolysis of ATP : role of an uncoating ATPase .
6227622	0	ATP	53,56	ATPase	128,134	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	moiety|nmod|START_ENTITY structure|nmod|moiety Alterations|nmod|structure reduce|nsubj|Alterations reduce|nmod|substrate substrate|nmod|END_ENTITY	Alterations in the structure of the ribose moiety of ATP reduce its effectiveness as a substrate for the sarcoplasmic reticulum ATPase .
6237610	0	ATP	53,56	ATPase	14,20	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	analogs|compound|START_ENTITY Inhibition|nmod|analogs Inhibition|nmod|activity activity|compound|END_ENTITY	Inhibition of ATPase activity of the recA protein by ATP ribose-modified analogs .
6241765	0	ATP	71,74	ATPase	109,115	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	START_ENTITY|xcomp|binding binding|nmod|END_ENTITY	Dependence on membrane lipids of the effect of vanadate on calcium and ATP binding to sarcoplasmic reticulum ATPase .
6453345	0	ATP	59,62	ATPase	28,34	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	step|compound|START_ENTITY actin|nmod|step effect|nmod|actin Mechanism|dep|effect Mechanism|nmod|END_ENTITY	Mechanism of the actomyosin ATPase : effect of actin on the ATP hydrolysis step .
7649708	6	ATP	1097,1100	ATPase	1205,1211	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	coupling|nsubj|START_ENTITY sites|acl:relcl|coupling vicinity|nmod|sites enzymes|nmod|vicinity binding|nmod|enzymes mechanisms|amod|binding generate|nsubj|mechanisms generate|dobj|microenvironments microenvironments|amod|END_ENTITY	Available experimental evidence suggests that the binding of creatine kinase and glycolytic enzymes in the vicinity of sites where ATP is hydrolyzed and functional coupling between these ATP regenerating mechanisms and ATPase can generate ATPase microenvironments that have an important role in the regulation of ATPase function .
7649708	6	ATP	1153,1156	ATPase	1205,1211	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	regenerating|compound|START_ENTITY coupling|nmod|regenerating sites|acl:relcl|coupling vicinity|nmod|sites enzymes|nmod|vicinity binding|nmod|enzymes mechanisms|amod|binding generate|nsubj|mechanisms generate|dobj|microenvironments microenvironments|amod|END_ENTITY	Available experimental evidence suggests that the binding of creatine kinase and glycolytic enzymes in the vicinity of sites where ATP is hydrolyzed and functional coupling between these ATP regenerating mechanisms and ATPase can generate ATPase microenvironments that have an important role in the regulation of ATPase function .
7665193	0	ATP	40,43	ATPase	69,75	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	phase|nmod|START_ENTITY scheme|nmod|phase hydrolysis|nsubj|scheme hydrolysis|nmod|END_ENTITY	A kinetic scheme for the early phase of ATP hydrolysis by actomyosin ATPase and its bioenergetic implications .
7789510	0	ATP	0,3	ATPase	89,95	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	synthesis|compound|START_ENTITY reversal|nsubj|synthesis reversal|nmod|activity activity|compound|END_ENTITY	ATP synthesis catalyzed by the mitochondrial F1-F0 ATP synthase is not a reversal of its ATPase activity .
7789510	0	ATP	51,54	ATPase	89,95	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	synthase|compound|START_ENTITY catalyzed|nmod|synthase synthesis|acl|catalyzed reversal|nsubj|synthesis reversal|nmod|activity activity|compound|END_ENTITY	ATP synthesis catalyzed by the mitochondrial F1-F0 ATP synthase is not a reversal of its ATPase activity .
7953071	0	ATP	178,181	ATPase	0,6	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	endogenous|dobj|START_ENTITY show|ccomp|endogenous show|nsubj|activity activity|amod|END_ENTITY	ATPase activity of melanosomes in liver pigment cells of Rana esculenta L. Luminometric methods show that melanosomes in liver pigment cells of Rana esculenta L. have endogenous ATP and ATPase activity .
8007838	0	ATP	29,32	ATPase	93,99	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	occlusion|nmod|START_ENTITY Uncoupling|nmod|occlusion hydrolysis|nsubj|Uncoupling hydrolysis|nmod|reticulum reticulum|dep|END_ENTITY	Uncoupling of occlusion from ATP hydrolysis activity in sarcoplasmic reticulum -LRB- Ca2 + + Mg2 + -RRB- - ATPase .
8051214	0	ATP	81,84	ATPase	54,60	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	hydrolysis|nmod|START_ENTITY required|nsubjpass|hydrolysis END_ENTITY|acl:relcl|required	N-ethylmaleimide-sensitive fusion protein : a trimeric ATPase whose hydrolysis of ATP is required for membrane fusion .
8148003	0	ATP	46,49	ATPase	98,104	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	hydrolysis|nsubj|START_ENTITY hydrolysis|nmod|END_ENTITY	Uncoupling by trehalose of Ca2 + transport and ATP hydrolysis by the plasma membrane -LRB- Ca2 + + Mg2 + -RRB- ATPase of kidney tubules .
8405373	0	ATP	172,175	ATPase	86,92	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	P-imidazolidate|compound|START_ENTITY reaction|nmod|P-imidazolidate formed|nmod|reaction reticulum|acl|formed END_ENTITY|nmod|reticulum	Identification of a cross-linked double-peptide from the catalytic site of the Ca -LRB- 2 + -RRB- - ATPase of sarcoplasmic reticulum formed by the Ca -LRB- 2 + -RRB- - and pH-dependent reaction with ATP gamma P-imidazolidate .
8816749	0	ATP	102,105	ATPase	0,6	ATP	ATPase	MESH:D000255	3654511(Tax:562)	Chemical	Gene	implications|nmod|START_ENTITY crosslinked|dobj|implications crosslinked|nsubj|activity activity|amod|END_ENTITY	ATPase activity of Escherichia_coli Rep helicase crosslinked to single-stranded DNA : implications for ATP driven helicase translocation .
8824206	0	ATP	119,122	ATPase	84,90	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	binding|compound|START_ENTITY defective|nmod|binding produces|xcomp|defective produces|nsubj|END_ENTITY	Mutagenesis of segment 487Phe-Ser-Arg-Asp-Arg-Lys492 of sarcoplasmic reticulum Ca2 + - ATPase produces pumps defective in ATP binding .
9480854	0	ATP	32,35	ATPase	84,90	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	hydrolysis|compound|START_ENTITY produced|nmod|hydrolysis produced|nmod|Ca Ca|dep|END_ENTITY	Control of heat produced during ATP hydrolysis by the sarcoplasmic reticulum Ca -LRB- 2 + -RRB- - ATPase in the absence of a Ca2 + gradient .
9506981	0	ATP	45,48	ATPase	77,83	ATP	ATPase	MESH:D000255	1769	Chemical	Gene	domains|compound|START_ENTITY domains|nmod|END_ENTITY	Steric limitations in the interaction of the ATP binding domains of the ArsA ATPase .
25613378	0	ATP	14,17	Ant2	30,34	ATP	Ant2	MESH:D000255	11740(Tax:10090)	Chemical	Gene	depletion|compound|START_ENTITY depletion|compound|END_ENTITY	Mitochondrial ATP transporter Ant2 depletion impairs erythropoiesis and B lymphopoiesis .
24089376	0	ATP	63,66	C-peptide	23,32	ATP	C-peptide	MESH:D000255	3630	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|END_ENTITY	Synergistic effects of C-peptide and insulin on low O2-induced ATP release from human erythrocytes .
25645390	0	ATP	20,23	CA3	42,45	ATP	CA3	MESH:D000255	54232(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY release|nmod|END_ENTITY	Pannexin-1-mediated ATP release from area CA3 drives mGlu5-dependent neuronal_oscillations .
24105910	1	ATP	87,90	CALHM1	63,69	ATP	CALHM1	MESH:D000255	546729(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|appos|channel	CALHM1 , a voltage-gated ATP channel .
3413798	0	ATP	8,11	CCl4	50,54	ATP	CCl4	MESH:D000255	116637(Tax:10116)	Chemical	Gene	induced|nsubj|START_ENTITY induced|nmod|END_ENTITY	Hepatic ATP content and hyperammonemia induced by CCl4 in rats .
20501849	0	ATP	125,128	CD25	27,31	ATP	CD25	MESH:D000255	3559	Chemical	Gene	levels|compound|START_ENTITY explained|nmod|levels explained|nsubjpass|depletion depletion|nmod|Foxp3 Foxp3|compound|END_ENTITY	Selective depletion of CD4 + CD25 + Foxp3 + regulatory T cells by low-dose cyclophosphamide is explained by reduced intracellular ATP levels .
14670449	0	ATP	14,17	CD4	40,43	ATP	CD4	MESH:D000255	12504(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|death death|nmod|thymocytes thymocytes|compound|END_ENTITY	Extracellular ATP induces cell death in CD4 + / CD8 + double-positive thymocytes in mice infected with Trypanosoma_cruzi .
18217906	0	ATP	14,17	CD4	36,39	ATP	CD4	MESH:D000255	920	Chemical	Gene	START_ENTITY|dobj|concentrations concentrations|nmod|cells cells|nummod|END_ENTITY	Intracellular ATP concentrations of CD4 cells in kidney transplant patients with and without infection .
18373845	0	ATP	14,17	CD4	74,77	ATP	CD4	MESH:D000255	920	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|ccomp|transfer transfer|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Extracellular ATP reduces HIV-1 transfer from immature dendritic cells to CD4 + T lymphocytes .
18493983	0	ATP	95,98	CD4	6,9	ATP	CD4	MESH:D000255	920	Chemical	Gene	production|amod|START_ENTITY conditions|nmod|production maintain|nmod|conditions maintain|nsubj|cells cells|compound|T T|compound|END_ENTITY	Human CD4 -LRB- + -RRB- T cells maintain specific functions even under conditions of extremely restricted ATP production .
19667966	0	ATP	21,24	CD4	42,45	ATP	CD4	MESH:D000255	920	Chemical	Gene	concentration|nsubj|START_ENTITY concentration|nmod|T-Cells T-Cells|compound|END_ENTITY	Is the intracellular ATP concentration of CD4 + T-Cells a predictive biomarker of immune status in stable transplant recipients ?
19715845	0	ATP	14,17	CD4	28,31	ATP	CD4	MESH:D000255	920	Chemical	Gene	levels|compound|START_ENTITY levels|nmod|lymphocytes lymphocytes|nummod|+ +|compound|END_ENTITY	Intracellular ATP levels in CD4 + lymphocytes are a risk marker of rejection and infection in renal graft recipients .
20501403	0	ATP	19,22	CD4	40,43	ATP	CD4	MESH:D000255	920	Chemical	Gene	determination|compound|START_ENTITY determination|nmod|END_ENTITY	-LSB- Clinical value of ATP determination in CD4 + cells of patients with cytomegaloviral_pneumonia after kidney transplantation -RSB- .
20501849	0	ATP	125,128	CD4	23,26	ATP	CD4	MESH:D000255	920	Chemical	Gene	levels|compound|START_ENTITY explained|nmod|levels explained|nsubjpass|depletion depletion|nmod|Foxp3 Foxp3|compound|END_ENTITY	Selective depletion of CD4 + CD25 + Foxp3 + regulatory T cells by low-dose cyclophosphamide is explained by reduced intracellular ATP levels .
21492353	0	ATP	72,75	CD4	68,71	ATP	CD4	MESH:D000255	920	Chemical	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Immune biomarker panel monitoring utilizing IDO enzyme activity and CD4 ATP levels : prediction of acute rejection vs. viral replication events .
22753871	0	ATP	8,11	CD4	84,87	ATP	CD4	MESH:D000255	920	Chemical	Gene	synthase|nsubj|START_ENTITY synthase|dobj|transfer transfer|nmod|cells cells|amod|HIV-1 HIV-1|nmod|END_ENTITY	Ectopic ATP synthase facilitates transfer of HIV-1 from antigen-presenting cells to CD4 -LRB- + -RRB- target cells .
23135604	0	ATP	25,28	CD4	57,60	ATP	CD4	MESH:D000255	920	Chemical	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Significant reduction of ATP production in PHA-activated CD4 + cells in 1-day-old blood from transplant patients .
23146475	0	ATP	58,61	CD4	83,86	ATP	CD4	MESH:D000255	920	Chemical	Gene	levels|compound|START_ENTITY levels|nmod|T T|compound|END_ENTITY	Clinical value of a single determination of intracellular ATP levels in stimulated CD4 + T lymphocytes in pediatric patients with stable liver transplantation .
25549254	0	ATP	103,106	CD4	121,124	ATP	CD4	MESH:D000255	920	Chemical	Gene	START_ENTITY|nmod|Lymphocytes Lymphocytes|compound|END_ENTITY	Relationship between the Peripheral Lymphocyte Response to Mycophenolic_Acid in vitro and the Level of ATP in Peripheral CD4 + Lymphocytes before and after Renal Transplantation .
21812012	0	ATP	14,17	CD44	26,30	ATP	CD44	MESH:D000255	12505(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Extracellular ATP induces CD44 shedding from macrophage-like P388D1 cells via the P2X7_receptor .
10799328	0	ATP	0,3	CFTR	20,24	ATP	CFTR	MESH:D000255	1080	Chemical	Gene	hydrolysis|nsubj|START_ENTITY hydrolysis|nmod|domain domain|amod|END_ENTITY	ATP hydrolysis by a CFTR domain : pharmacology and effects of G551D mutation .
10880569	0	ATP	41,44	CFTR	14,18	ATP	CFTR	MESH:D000255	1080	Chemical	Gene	gating|nmod|START_ENTITY channel|acl|gating Regulation|dep|channel Regulation|nmod|Cl Cl|compound|END_ENTITY	Regulation of CFTR Cl - channel gating by ATP binding and hydrolysis .
1279436	0	ATP	40,43	CFTR	11,15	ATP	CFTR	MESH:D000255	1080	Chemical	Gene	levels|compound|START_ENTITY conductance|nmod|levels conductance|nsubj|Control Control|nmod|chloride chloride|amod|END_ENTITY	Control of CFTR chloride conductance by ATP levels through non-hydrolytic binding .
14502440	0	ATP	54,57	CFTR	23,27	ATP	CFTR	MESH:D000255	100754506	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Negative regulation of CFTR activity by extracellular ATP involves P2Y2 receptors in CFTR-expressing CHO cells .
14602047	0	ATP	27,30	CFTR	64,68	ATP	CFTR	MESH:D000255	1080	Chemical	Gene	hydrolysis|compound|START_ENTITY kinase|dobj|hydrolysis kinase|nmod|domain domain|amod|END_ENTITY	Protein kinase A regulates ATP hydrolysis and dimerization by a CFTR -LRB- cystic_fibrosis_transmembrane_conductance_regulator -RRB- domain .
15371258	0	ATP	11,14	CFTR	67,71	ATP	CFTR	MESH:D000255	1080	Chemical	Gene	Release|nmod|START_ENTITY involves|nsubj|Release involves|dobj|transport transport|compound|END_ENTITY	Release of ATP from retinal pigment epithelial cells involves both CFTR and vesicular transport .
15623556	0	ATP	31,34	CFTR	17,21	ATP	CFTR	MESH:D000255	1080	Chemical	Gene	binding|nsubj|START_ENTITY requires|xcomp|binding requires|nsubj|gating gating|nmod|END_ENTITY	Normal gating of CFTR requires ATP binding to both nucleotide-binding_domains and hydrolysis at the second nucleotide-binding domain .
16470247	0	ATP	35,38	CFTR	0,4	ATP	CFTR	MESH:D000255	12638(Tax:10090)	Chemical	Gene	sensitivity|compound|START_ENTITY required|nmod|sensitivity required|nsubjpass|END_ENTITY	CFTR is required for PKA-regulated ATP sensitivity of Kir1 .1 potassium channels in mouse kidney .
16966475	0	ATP	8,11	CFTR	82,86	ATP	CFTR	MESH:D000255	1080	Chemical	Gene	sites|amod|START_ENTITY sites|appos|END_ENTITY	The two ATP binding sites of cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- play distinct roles in gating kinetics and energetics .
18605986	0	ATP	16,19	CFTR	79,83	ATP	CFTR	MESH:D000255	1080	Chemical	Gene	occlusion|compound|START_ENTITY occlusion|nmod|domain domain|nmod|END_ENTITY	Mg2 + - dependent ATP occlusion at the first nucleotide-binding domain -LRB- NBD1 -RRB- of CFTR does not require the second -LRB- NBD2 -RRB- .
20421370	0	ATP	7,10	CFTR	58,62	ATP	CFTR	MESH:D000255	1080	Chemical	Gene	binding|compound|START_ENTITY mediated|nsubj|binding mediated|nmod|dimer dimer|nmod|channel channel|amod|END_ENTITY	Stable ATP binding mediated by a partial NBD dimer of the CFTR chloride channel .
20628841	0	ATP	9,12	CFTR	115,119	ATP	CFTR	MESH:D000255	1080	Chemical	Gene	important|nsubj|START_ENTITY important|nmod|cycle cycle|nmod|END_ENTITY	A stable ATP binding to the nucleotide binding domain is important for reliable gating cycle in an ABC transporter CFTR .
20861014	0	ATP	44,47	CFTR	162,166	ATP	CFTR	MESH:D000255	1080	Chemical	Gene	site|compound|START_ENTITY Optimization|nmod|site improves|nsubj|Optimization improves|ccomp|transmembrane transmembrane|dobj|channels channels|appos|END_ENTITY	Optimization of the degenerated interfacial ATP binding site improves the function of disease-related mutant cystic_fibrosis transmembrane conductance regulator -LRB- CFTR -RRB- channels .
20876359	0	ATP	91,94	CFTR	34,38	ATP	CFTR	MESH:D000255	373725(Tax:8355)	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of F1296 and N1303 of CFTR in induced-fit conformational change in response to ATP binding at NBD2 .
21424674	0	ATP	42,45	CFTR	125,129	ATP	CFTR	MESH:D000255	1080	Chemical	Gene	modulation|compound|START_ENTITY study|nmod|modulation study|nmod|features features|nmod|domains domains|nmod|END_ENTITY	Small-angle X-ray scattering study of the ATP modulation of the structural features of the nucleotide binding domains of the CFTR in solution .
21461971	0	ATP	0,3	CFTR	58,62	ATP	CFTR	MESH:D000255	1080	Chemical	Gene	asymmetry|compound|START_ENTITY asymmetry|nmod|conformation conformation|nmod|channel channel|amod|END_ENTITY	ATP hydrolysis-dependent asymmetry of the conformation of CFTR channel pore .
21943397	0	ATP	36,39	CFTR	0,4	ATP	CFTR	MESH:D000255	24255(Tax:10116)	Chemical	Gene	efflux|compound|START_ENTITY mediates|dobj|efflux mediates|nsubj|END_ENTITY	CFTR mediates noradrenaline-induced ATP efflux from DRG neurons .
22711960	0	ATP	0,3	CFTR	64,68	ATP	CFTR	MESH:D000255	12638(Tax:10090)	Chemical	Gene	secretion|compound|START_ENTITY secretion|dep|role role|nmod|END_ENTITY	ATP secretion in the male reproductive tract : essential role of CFTR .
23214920	0	ATP	27,30	CFTR	42,46	ATP	CFTR	MESH:D000255	1080	Chemical	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	The power stroke driven by ATP binding in CFTR as studied by molecular dynamics simulations .
23921386	0	ATP	0,3	CFTR	155,159	ATP	CFTR	MESH:D000255	1080	Chemical	Gene	mutually|compound|START_ENTITY influence|nsubj|mutually influence|dobj|cystic_fibrosis_transmembrane_conductance_regulator cystic_fibrosis_transmembrane_conductance_regulator|appos|END_ENTITY	ATP and AMP mutually influence their interaction with the ATP-binding cassette -LRB- ABC -RRB- adenylate kinase cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- at separate binding sites .
23948742	0	ATP	128,131	CFTR	61,65	ATP	CFTR	MESH:D000255	1080	Chemical	Gene	supplementation|compound|START_ENTITY prevented|nmod|supplementation cells|acl:relcl|prevented inhibit|nmod|cells inhibit|dobj|function function|amod|END_ENTITY	Ethanol and its non-oxidative metabolites profoundly inhibit CFTR function in pancreatic epithelial cells which is prevented by ATP supplementation .
25225552	0	ATP	50,53	CFTR	36,40	ATP	CFTR	MESH:D000255	1080	Chemical	Gene	converts|dobj|START_ENTITY converts|nsubj|substitution substitution|nmod|END_ENTITY	A single amino_acid substitution in CFTR converts ATP to an inhibitory ligand .
26174774	0	ATP	105,108	CFTR	56,60	ATP	CFTR	MESH:D000255	1080	Chemical	Gene	Gating|nmod|START_ENTITY Channel|acl|Gating Channel|compound|END_ENTITY	Benzopyrimido-pyrrolo-oxazine-dione -LRB- R -RRB- - BPO-27 Inhibits CFTR Chloride Channel Gating by Competition with ATP .
26174774	1	ATP	645,648	CFTR	620,624	ATP	CFTR	MESH:D000255	1080	Chemical	Gene	whereas|compound|START_ENTITY show|nmod|whereas show|dobj|enantiomerically enantiomerically|dep|END_ENTITY	We used computational chemistry and patch-clamp to show that enantiomerically pure -LRB- R -RRB- - BPO-27 inhibits CFTR by competition with ATP , whereas -LRB- S -RRB- - BPO-27 is inactive .
7512348	0	ATP	42,45	CFTR	12,16	ATP	CFTR	MESH:D000255	1080	Chemical	Gene	cycle|compound|START_ENTITY gating|nmod|cycle channel|acl|gating Coupling|dep|channel Coupling|nmod|Cl Cl|compound|END_ENTITY	Coupling of CFTR Cl - channel gating to an ATP hydrolysis cycle .
7520292	0	ATP	10,13	CFTR	31,35	ATP	CFTR	MESH:D000255	1080	Chemical	Gene	concentration|compound|START_ENTITY Effect|nmod|concentration Effect|nmod|Cl Cl|compound|END_ENTITY	Effect of ATP concentration on CFTR Cl - channels : a kinetic analysis of channel regulation .
7532359	0	ATP	83,86	CFTR	14,18	ATP	CFTR	MESH:D000255	1080	Chemical	Gene	cells|nmod|START_ENTITY conductance|nmod|cells Activation|dep|conductance Activation|nmod|Cl Cl|compound|END_ENTITY	Activation of CFTR Cl - conductance in polarized T84 cells by luminal extracellular ATP .
7541313	0	ATP	95,98	CFTR	0,4	ATP	CFTR	MESH:D000255	1080	Chemical	Gene	mechanism|nmod|START_ENTITY regulates|nmod|mechanism regulates|nsubj|END_ENTITY	CFTR regulates outwardly rectifying chloride channels through an autocrine mechanism involving ATP .
7543023	0	ATP	71,74	CFTR	25,29	ATP	CFTR	MESH:D000255	1080	Chemical	Gene	associated|parataxis|START_ENTITY associated|nsubj|states states|nmod|END_ENTITY	Conformational states of CFTR associated with channel gating : the role ATP binding and hydrolysis .
8661502	0	ATP	60,63	CFTR	0,4	ATP	CFTR	MESH:D000255	100754506	Chemical	Gene	conductance|compound|START_ENTITY have|dobj|conductance have|nsubj|channels channels|amod|END_ENTITY	CFTR channels expressed in CHO cells do not have detectable ATP conductance .
8662751	0	ATP	92,95	CFTR	62,66	ATP	CFTR	MESH:D000255	1080	Chemical	Gene	channel|compound|START_ENTITY function|nmod|channel function|nsubj|cystic_fibrosis_transmembrane_conductance_regulator cystic_fibrosis_transmembrane_conductance_regulator|appos|END_ENTITY	Purified cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- does not function as an ATP channel .
8760028	0	ATP	49,52	CFTR	67,71	ATP	CFTR	MESH:D000255	1080	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|Cl Cl|compound|END_ENTITY	Hydrolytic and nonhydrolytic interactions in the ATP regulation of CFTR Cl - conductance .
9357772	0	ATP	73,76	CFTR	51,55	ATP	CFTR	MESH:D000255	1080	Chemical	Gene	hydrolysis|compound|START_ENTITY produced|nmod|hydrolysis pore|acl|produced pore|amod|END_ENTITY	Block by MOPS reveals a conformation change in the CFTR pore produced by ATP hydrolysis .
9463368	0	ATP	37,40	CFTR	0,4	ATP	CFTR	MESH:D000255	492302(Tax:9615)	Chemical	Gene	channel|compound|START_ENTITY Cl|dep|channel Cl|compound|END_ENTITY	CFTR Cl - channel and CFTR-associated ATP channel : distinct pores regulated by common gates .
9511931	0	ATP	12,15	CFTR	74,78	ATP	CFTR	MESH:D000255	1080	Chemical	Gene	Coupling|nmod|START_ENTITY hydrolysis|nsubj|Coupling hydrolysis|nmod|channel channel|acl|gating gating|nmod|END_ENTITY	Coupling of ATP hydrolysis with channel gating by purified , reconstituted CFTR .
9815080	0	ATP	20,23	CFTR	62,66	ATP	CFTR	MESH:D000255	1080	Chemical	Gene	release|compound|START_ENTITY requires|nsubj|release requires|dobj|activity activity|amod|END_ENTITY	Deformation-induced ATP release from red blood cells requires CFTR activity .
12044622	0	ATP	0,3	CGRP	35,39	ATP	CGRP	MESH:D000255	24241(Tax:10116)	Chemical	Gene	enhance|nsubj|START_ENTITY enhance|dobj|release release|compound|END_ENTITY	ATP can enhance the proton-induced CGRP release through P2Y receptors and secondary PGE -LRB- 2 -RRB- release in isolated rat dura mater .
18584896	0	ATP	102,105	CGRP	85,89	ATP	CGRP	MESH:D000255	24241(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Delayed anti-arrhythmic effect of nitroglycerin in anesthetized rats : involvement of CGRP , PKC and mK ATP channels .
23527964	2	ATP	278,281	CK1	307,310	ATP	CK1	MESH:D000255	122011	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	ATP binding kinase domain of CK1 is essential for regulating several key cell cycle signal transduction pathways .
10581548	0	ATP	21,24	CK2	62,65	ATP	CK2	MESH:D000255	100384477(Tax:4577)	Chemical	Gene	START_ENTITY|nmod|site site|nmod|END_ENTITY	GTP plus water mimic ATP in the active site of protein kinase CK2 .
10882732	0	ATP	19,22	CK2	136,139	ATP	CK2	MESH:D000255	100384477(Tax:4577)	Chemical	Gene	replacement|nmod|START_ENTITY induces|nsubj|replacement induces|nmod|site site|nmod|END_ENTITY	The replacement of ATP by the competitive inhibitor emodin induces conformational modifications in the catalytic site of protein kinase CK2 .
11604527	0	ATP	77,80	CK2	70,73	ATP	CK2	MESH:D000255	100384477(Tax:4577)	Chemical	Gene	features|nmod|START_ENTITY features|dobj|inhibition inhibition|nmod|END_ENTITY	Structural features underlying selective inhibition of protein kinase CK2 by ATP site-directed tetrabromo-2-benzotriazole .
12748192	2	ATP	381,384	CKII	357,361	ATP	CKII	MESH:D000255	1457	Chemical	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	We recently reported that CKBBP1/SAG/ROC2 / Rbx2 associates with the beta-subunit of CKII and is phosphorylated by purified CKII in the presence of ATP in vitro .
17664348	0	ATP	12,15	CLC-1	30,35	ATP	CLC-1	MESH:D000255	1180	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	Cytoplasmic ATP inhibition of CLC-1 is enhanced by low pH. The CLC-1 Cl -LRB- - -RRB- channel is abundantly expressed on the plasma membrane of muscle cells , and the membrane potential of muscle cells is largely controlled by the activity of this Cl -LRB- - -RRB- channel .
21444658	0	ATP	11,14	CLC-1	62,67	ATP	CLC-1	MESH:D000255	1180	Chemical	Gene	Binding|nmod|START_ENTITY domains|nsubj|Binding domains|nmod|region region|nmod|END_ENTITY	Binding of ATP to the CBS domains in the C-terminal region of CLC-1 .
21277129	0	ATP	43,46	CPT_II	13,19	ATP	CPT II	MESH:D000255	1376	Chemical	Gene	levels|compound|START_ENTITY levels|nummod|END_ENTITY	Thermolabile CPT_II variants and low blood ATP levels are closely related to severity of acute encephalopathy in Japanese children .
15107014	0	ATP	103,106	Ca2	75,78	ATP	Ca2	MESH:D000255	54231(Tax:10116)	Chemical	Gene	play|nmod|START_ENTITY play|dobj|role role|nmod|inhibition inhibition|nmod|entry entry|compound|END_ENTITY	Actin filaments play a permissive role in the inhibition of store-operated Ca2 + entry by extracellular ATP in rat brown adipocytes .
15163630	0	ATP	121,124	Ca2	17,20	ATP	Ca2	MESH:D000255	12349(Tax:10090)	Chemical	Gene	production|compound|START_ENTITY requirement|nmod|production have|dobj|requirement have|nsubj|oscillations oscillations|amod|END_ENTITY	Sperm-triggered -LSB- Ca2 + -RSB- oscillations and Ca2 + homeostasis in the mouse egg have an absolute requirement for mitochondrial ATP production .
16554405	0	ATP	48,51	Ca2	0,3	ATP	Ca2	MESH:D000255	760	Chemical	Gene	production|compound|START_ENTITY increase|dobj|production mobilizing|ccomp|increase aberrations|dep|mobilizing +|dep|aberrations +|compound|END_ENTITY	Ca2 + - mobilizing agonists increase mitochondrial ATP production to accelerate cytosolic Ca2 + removal : aberrations in human complex_I_deficiency .
16554405	0	ATP	48,51	Ca2	87,90	ATP	Ca2	MESH:D000255	760	Chemical	Gene	production|compound|START_ENTITY increase|dobj|production increase|advcl|accelerate accelerate|dobj|removal removal|amod|END_ENTITY	Ca2 + - mobilizing agonists increase mitochondrial ATP production to accelerate cytosolic Ca2 + removal : aberrations in human complex_I_deficiency .
16899570	0	ATP	37,40	Ca2	108,111	ATP	Ca2	MESH:D000255	760	Chemical	Gene	responses|nmod|START_ENTITY due|nsubj|responses due|nmod|END_ENTITY	Pregnancy-enhanced Ca2 + responses to ATP in uterine artery endothelial cells is due to greater capacitative Ca2 + entry rather than altered receptor coupling .
16899570	0	ATP	37,40	Ca2	19,22	ATP	Ca2	MESH:D000255	760	Chemical	Gene	responses|nmod|START_ENTITY responses|amod|END_ENTITY	Pregnancy-enhanced Ca2 + responses to ATP in uterine artery endothelial cells is due to greater capacitative Ca2 + entry rather than altered receptor coupling .
1694696	0	ATP	138,141	Ca2	74,77	ATP	Ca2	MESH:D000255	54231(Tax:10116)	Chemical	Gene	provided|nmod|START_ENTITY permeabilised|advcl|provided permeabilised|nmod|concentrations concentrations|amod|END_ENTITY	Rat pancreatic acini permeabilised with streptolysin O secrete amylase at Ca2 + concentrations in the micromolar range , when provided with ATP and GTP gamma S .
17516060	0	ATP	73,76	Ca2	0,3	ATP	Ca2	MESH:D000255	760	Chemical	Gene	modulated|nmod|START_ENTITY modulated|nsubjpass|+ +|nummod|END_ENTITY	Ca2 + current of frog vestibular hair cells is modulated by intracellular ATP but not by long-lasting depolarisation .
1883987	0	ATP	14,17	Ca2	37,40	ATP	Ca2	MESH:D000255	760	Chemical	Gene	elevates|nsubj|START_ENTITY elevates|dobj|+ +|amod|END_ENTITY	Extracellular ATP elevates cytosolic Ca2 + in cochlear inner hair cells .
21159734	0	ATP	56,59	Ca2	15,18	ATP	Ca2	MESH:D000255	12349(Tax:10090)	Chemical	Gene	release|compound|START_ENTITY distention-induced|dobj|release distention-induced|nsubj|suppresses suppresses|amod|END_ENTITY	Store-operated Ca2 + entry suppresses distention-induced ATP release from the urothelium .
2478028	0	ATP	0,3	Ca2	21,24	ATP	Ca2	MESH:D000255	54231(Tax:10116)	Chemical	Gene	transients|compound|START_ENTITY transients|amod|END_ENTITY	ATP receptor-induced Ca2 + transients in cardiac myocytes : sources of mobilized Ca2 + .
2478028	0	ATP	0,3	Ca2	79,82	ATP	Ca2	MESH:D000255	54231(Tax:10116)	Chemical	Gene	transients|compound|START_ENTITY transients|dep|sources sources|nmod|+ +|compound|END_ENTITY	ATP receptor-induced Ca2 + transients in cardiac myocytes : sources of mobilized Ca2 + .
6832366	0	ATP	45,48	Ca2	18,21	ATP	Ca2	MESH:D000255	54231(Tax:10116)	Chemical	Gene	synthesis|compound|START_ENTITY inhibition|nmod|synthesis +|dep|inhibition +|amod|END_ENTITY	Mn2 + prevents the Ca2 + - induced inhibition of ATP synthesis in brain mitochondria .
7478924	6	ATP	1078,1081	Ca2	979,982	ATP	Ca2	MESH:D000255	54231(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY comparable|nmod|effects comparable|nsubj|transiently transiently|compound|END_ENTITY	Diadenosine_polyphosphates -LRB- Ap3A-Ap6A -RRB- increased -LSB- Ca2 + -RSB- i transiently with an initial peak and a secondary plateau phase comparable to the effects of ATP or Ang_II .
7573408	0	ATP	0,3	Ca2	36,39	ATP	Ca2	MESH:D000255	54231(Tax:10116)	Chemical	Gene	depletion|compound|START_ENTITY inhibits|nsubj|depletion inhibits|dobj|entry entry|amod|END_ENTITY	ATP depletion inhibits capacitative Ca2 + entry in rat thymic lymphocytes .
7623275	0	ATP	37,40	Ca2	55,58	ATP	Ca2	MESH:D000255	54231(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|+ +|amod|END_ENTITY	Release of Ca2 + by noradrenaline and ATP from the same Ca2 + store sensitive to both InsP3 and Ca2 + in rat portal vein myocytes .
7675633	0	ATP	60,63	Ca2	19,22	ATP	Ca2	MESH:D000255	12349(Tax:10090)	Chemical	Gene	stimulated|nmod|START_ENTITY macrophages|acl|stimulated stores|nmod|macrophages stores|amod|END_ENTITY	Rapid refilling of Ca2 + stores in macrophages stimulated by ATP involves the sequential activation of phospholipase D and protein kinase C. Ca2 + movements between intracellular stores , the cytoplasm and external solution were analysed in murine peritoneal macrophages stimulated by various agonists .
8726862	6	ATP	976,979	Ca2	1013,1016	ATP	Ca2	MESH:D000255	100009156(Tax:9986)	Chemical	Gene	START_ENTITY|acl|induced induced|dobj|increase increase|nmod|owing owing|compound|END_ENTITY	Extracellular ATP induced a transient increase in -LSB- Ca2 + -RSB- i owing to the release of Ca2 + from intracellular stores and Ca2 + entering the cell across the plasma membrane .
8944628	0	ATP	0,3	Ca2	69,72	ATP	Ca2	MESH:D000255	760	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|channels channels|nmod|release release|nmod|+ +|compound|END_ENTITY	ATP activates K and Cl channels via purinoceptor-mediated release of Ca2 + in human coronary artery smooth muscle .
9176153	0	ATP	14,17	Ca2	29,32	ATP	Ca2	MESH:D000255	396257(Tax:9031)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|i i|compound|END_ENTITY	Extracellular ATP modulates -LSB- Ca2 + -RSB- i in retinoic_acid-treated embryonic chondrocytes .
9201553	0	ATP	0,3	Ca2	36,39	ATP	Ca2	MESH:D000255	54231(Tax:10116)	Chemical	Gene	+|advmod|START_ENTITY +|nsubj|END_ENTITY	ATP , thapsigargin and cAMP increase Ca2 + in rat hepatocytes by activating three different Ca2 + influx pathways .
9201553	0	ATP	0,3	Ca2	90,93	ATP	Ca2	MESH:D000255	54231(Tax:10116)	Chemical	Gene	+|advmod|START_ENTITY +|advcl|activating activating|dobj|pathways pathways|compound|END_ENTITY	ATP , thapsigargin and cAMP increase Ca2 + in rat hepatocytes by activating three different Ca2 + influx pathways .
9231716	5	ATP	1015,1018	Ca2	1054,1057	ATP	Ca2	MESH:D000255	12349(Tax:10090)	Chemical	Gene	response|nmod|START_ENTITY show|dobj|response show|advcl|show show|nsubj|cells cells|nmod|-RSB- -RSB-|compound|END_ENTITY	Glial cells in lowered -LSB- Ca2 + -RSB- e -LRB- 0.1-0 .5 mM -RRB- show an increased -LSB- Ca2 + -RSB- i response to bath application of ATP , whereas glial cells in increased -LSB- Ca2 + -RSB- e -LRB- 10-15 mM -RRB- show a decreased -LSB- Ca2 + -RSB- i response to ATP .
9231716	5	ATP	1109,1112	Ca2	1054,1057	ATP	Ca2	MESH:D000255	12349(Tax:10090)	Chemical	Gene	response|nmod|START_ENTITY show|dobj|response show|nsubj|cells cells|nmod|-RSB- -RSB-|compound|END_ENTITY	Glial cells in lowered -LSB- Ca2 + -RSB- e -LRB- 0.1-0 .5 mM -RRB- show an increased -LSB- Ca2 + -RSB- i response to bath application of ATP , whereas glial cells in increased -LSB- Ca2 + -RSB- e -LRB- 10-15 mM -RRB- show a decreased -LSB- Ca2 + -RSB- i response to ATP .
9655512	0	ATP	23,26	Ca2	63,66	ATP	Ca2	MESH:D000255	280740(Tax:9913)	Chemical	Gene	secretion|nmod|START_ENTITY revealed|nsubj|secretion revealed|nmod|modulation modulation|amod|END_ENTITY	Localized secretion of ATP and opioids revealed through single Ca2 + channel modulation in bovine chromaffin cells .
16387651	0	ATP	11,14	Cdc6	29,33	ATP	Cdc6	MESH:D000255	990	Chemical	Gene	hydrolysis|nsubj|START_ENTITY hydrolysis|nmod|END_ENTITY	Sequential ATP hydrolysis by Cdc6 and ORC directs loading of the Mcm2-7 helicase .
25202010	0	ATP	60,63	Chaperonin_GroEL	78,94	ATP	Chaperonin GroEL	MESH:D000255	7872393(Tax:562)	Chemical	Gene	Hydrolysis|compound|START_ENTITY Hydrolysis|nmod|END_ENTITY	Asp-52 in Combination with Asp-398 Plays a Critical Role in ATP Hydrolysis of Chaperonin_GroEL .
18227271	0	ATP	77,80	ClC-1	28,33	ATP	ClC-1	MESH:D000255	1180	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	The muscle chloride channel ClC-1 is not directly regulated by intracellular ATP .
23632988	0	ATP	44,47	ClC-2	14,19	ATP	ClC-2	MESH:D000255	1181	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of ClC-2 gating by intracellular ATP .
10383442	0	ATP	98,101	ClpA	93,97	ATP	ClpA	MESH:D000255	50945	Chemical	Gene	site|compound|START_ENTITY site|compound|END_ENTITY	Concurrent chaperone and protease activities of ClpAP and the requirement for the N-terminal ClpA ATP binding site for chaperone activity .
20736421	0	ATP	55,58	Connexin	0,8	ATP	Connexin	MESH:D000255	100128922	Chemical	Gene	release|nmod|START_ENTITY release|amod|END_ENTITY	Connexin hemichannel-mediated CO2-dependent release of ATP in the medulla oblongata contributes to central respiratory chemosensitivity .
25760687	0	ATP	47,50	Connexin_43	14,25	ATP	Connexin 43	MESH:D000255	2697	Chemical	Gene	Release|compound|START_ENTITY Release|compound|END_ENTITY	Inhibition of Connexin_43 Hemichannel-Mediated ATP Release Attenuates Early Inflammation During the Foreign Body Response .
11110786	0	ATP	64,67	Cystic_fibrosis_transmembrane_conductance_regulator	0,51	ATP	Cystic fibrosis transmembrane conductance regulator	MESH:D000255	1080	Chemical	Gene	release|compound|START_ENTITY facilitates|dobj|release facilitates|nsubj|END_ENTITY	Cystic_fibrosis_transmembrane_conductance_regulator facilitates ATP release by stimulating a separate ATP release channel for autocrine control of cell volume regulation .
12729460	0	ATP	14,17	Egr-1	66,71	ATP	Egr-1	MESH:D000255	1958	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Extracellular ATP stimulates the early_growth_response_protein_1 -LRB- Egr-1 -RRB- via a protein kinase C-dependent pathway in the human osteoblastic HOBIT cell line .
8287895	0	ATP	104,107	Endothelin-1	0,12	ATP	Endothelin-1	MESH:D000255	100009270(Tax:9986)	Chemical	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	Endothelin-1 enhances vasoconstrictor responses to exogenously administered and neurogenically released ATP in rabbit isolated perfused arteries .
7665570	0	ATP	0,3	F0F1-ATPase	21,32	ATP	F0F1-ATPase	MESH:D000255	514	Chemical	Gene	synthesis|compound|START_ENTITY synthesis|nmod|END_ENTITY	ATP synthesis by the F0F1-ATPase from the thermophilic Bacillus PS3 co-reconstituted with bacteriorhodopsin into liposomes .
10500204	0	ATP	33,36	Friedreich_ataxia	65,82	ATP	Friedreich ataxia	MESH:D000255	2395	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	Deficit of in vivo mitochondrial ATP production in patients with Friedreich_ataxia .
24344269	6	ATP	806,809	G0s2	777,781	ATP	G0s2	MESH:D000255	50486	Chemical	Gene	production|compound|START_ENTITY increases|dobj|production increases|nsubj|END_ENTITY	Mitochondria-targeted , FRET-based ATP biosensor and ATP production assay in a semiintact cell system revealed that G0s2 increases mitochondrial ATP production .
26209183	0	ATP	48,51	GSK-3b	41,47	ATP	GSK-3b	MESH:D000255	2932	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Molecular dynamics simulation studies of GSK-3b ATP competitive inhibitors : understanding the factors contributing to selectivity .
20308583	0	ATP	68,71	GroEL	45,50	ATP	GroEL	MESH:D000255	3329	Chemical	Gene	concentrations|compound|START_ENTITY END_ENTITY|nmod|concentrations	Out-of-equilibrium conformational cycling of GroEL under saturating ATP concentrations .
19748989	0	ATP	14,17	HLA-G	76,81	ATP	HLA-G	MESH:D000255	3135	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|nmod|END_ENTITY	Extracellular ATP acting at the P2X7_receptor inhibits secretion of soluble HLA-G from human monocytes .
25433210	0	ATP	33,36	HSC-70	26,32	ATP	HSC-70	MESH:D000255	3312	Chemical	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	New crystal structures of HSC-70 ATP binding domain confirm the role of individual binding pockets and suggest a new method of inhibition .
26474416	0	ATP	47,50	Helicase	68,76	ATP	Helicase	MESH:D000255	164045	Chemical	Gene	Binding|compound|START_ENTITY Binding|nmod|END_ENTITY	The Q Motif Is Involved in DNA Binding but Not ATP Binding in ChlR1 Helicase .
11060043	0	ATP	38,41	Hsp90	23,28	ATP	Hsp90	MESH:D000255	3320	Chemical	Gene	hydrolysis|nsubj|START_ENTITY involves|ccomp|hydrolysis involves|nsubj|release release|nmod|END_ENTITY	Polypeptide release by Hsp90 involves ATP hydrolysis and is enhanced by the co-chaperone p23 .
11441008	0	ATP	12,15	Hsp90	34,39	ATP	Hsp90	MESH:D000255	3320	Chemical	Gene	hydrolysis|nsubj|START_ENTITY hydrolysis|nmod|dimer dimer|amod|END_ENTITY	Coordinated ATP hydrolysis by the Hsp90 dimer .
11751878	0	ATP	49,52	Hsp90	89,94	ATP	Hsp90	MESH:D000255	3320	Chemical	Gene	binding|nsubj|START_ENTITY binding|nmod|domain domain|nmod|END_ENTITY	A Nucleotide-dependent molecular switch controls ATP binding at the C-terminal domain of Hsp90 .
16741950	0	ATP	50,53	Hsp90	63,68	ATP	Hsp90	MESH:D000255	3320	Chemical	Gene	stimulation|nmod|START_ENTITY controls|nsubj|stimulation controls|dobj|expression expression|amod|END_ENTITY	Nucleotide receptors stimulation by extracellular ATP controls Hsp90 expression through APE1/Ref -1 in thyroid_cancer cells : a novel tumorigenic pathway .
16842154	0	ATP	73,76	Hsp90	56,61	ATP	Hsp90	MESH:D000255	3320	Chemical	Gene	site|compound|START_ENTITY site|compound|END_ENTITY	Geldanamycin , radicicol , and chimeric inhibitors of the Hsp90 N-terminal ATP binding site .
18492664	0	ATP	80,83	Hsp90	98,103	ATP	Hsp90	MESH:D000255	3320	Chemical	Gene	hydrolysis|compound|START_ENTITY facilitate|dobj|hydrolysis facilitate|nmod|END_ENTITY	Intra - and intermonomer interactions are required to synergistically facilitate ATP hydrolysis in Hsp90 .
19234469	0	ATP	69,72	Hsp90	36,41	ATP	Hsp90	MESH:D000255	855836(Tax:4932)	Chemical	Gene	hydrolysis|compound|START_ENTITY coupled|nmod|hydrolysis coupled|nsubjpass|changes changes|nmod|END_ENTITY	The large conformational changes of Hsp90 are only weakly coupled to ATP hydrolysis .
20688913	0	ATP	0,3	Hsp90	15,20	ATP	Hsp90	MESH:D000255	3320	Chemical	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	ATP binding to Hsp90 is sufficient for effective chaperoning of p53 protein .
21439406	0	ATP	67,70	Hsp90	0,5	ATP	Hsp90	MESH:D000255	855224(Tax:4932)	Chemical	Gene	assembly|compound|START_ENTITY participate|nmod|assembly participate|nsubj|Yme1 Yme1|amod|END_ENTITY	Hsp90 and mitochondrial proteases Yme1 and Yta10/12 participate in ATP synthase assembly in Saccharomyces_cerevisiae .
21778327	0	ATP	122,125	Hsp90	157,162	ATP	Hsp90	MESH:D000255	855836(Tax:4932)	Chemical	Gene	pocket|compound|START_ENTITY pocket|nmod|END_ENTITY	Features of the Streptomyces_hygroscopicus HtpG reveal how partial geldanamycin resistance can arise with mutation to the ATP binding pocket of a eukaryotic Hsp90 .
24125885	0	ATP	44,47	Hsp90	36,41	ATP	Hsp90	MESH:D000255	3320	Chemical	Gene	pocket|compound|START_ENTITY pocket|nmod:poss|END_ENTITY	Targeting the hydrophobic region of Hsp90 's ATP binding pocket with novel 1,3,5-triazines .
24450340	0	ATP	24,27	Hsp90	53,58	ATP	Hsp90	MESH:D000255	3320	Chemical	Gene	synthase|nsubj|START_ENTITY synthase|xcomp|modulate modulate|dobj|machinery machinery|amod|END_ENTITY	Cruentaren A binds F1F0 ATP synthase to modulate the Hsp90 protein folding machinery .
24462206	0	ATP	92,95	Hsp90	58,63	ATP	Hsp90	MESH:D000255	3320	Chemical	Gene	mechanism|compound|START_ENTITY supports|dobj|mechanism supports|nsubj|asymmetry asymmetry|nmod|state state|nmod|END_ENTITY	Structural asymmetry in the closed state of mitochondrial Hsp90 -LRB- TRAP1 -RRB- supports a two-step ATP hydrolysis mechanism .
25383758	4	ATP	660,663	Hsp90	722,727	ATP	Hsp90	MESH:D000255	3320	Chemical	Gene	enhance|nsubj|START_ENTITY enhance|dobj|activity activity|nmod|END_ENTITY	Mechanistically , the ATP generated from Pgk1 may enhance the chaperone activity of Hsp90 , an ATPase known to associate with Pgk1 .
26929380	0	ATP	71,74	Hsp90	14,19	ATP	Hsp90	MESH:D000255	3320	Chemical	Gene	binding|advmod|START_ENTITY binding|nsubj|END_ENTITY	Mitochondrial Hsp90 is a ligand-activated molecular chaperone coupling ATP binding to dimer closure through a coiled-coil intermediate .
8626558	0	ATP	18,21	Hsp90	44,49	ATP	Hsp90	MESH:D000255	3320	Chemical	Gene	properties|compound|START_ENTITY properties|nmod|END_ENTITY	Assessment of the ATP binding properties of Hsp90 .
9707442	0	ATP	0,3	Hsp90	64,69	ATP	Hsp90	MESH:D000255	855836(Tax:4932)	Chemical	Gene	essential|nsubj|START_ENTITY essential|nmod|function function|nmod|chaperone chaperone|amod|END_ENTITY	ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo .
9817749	0	ATP	42,45	Hsp90	20,25	ATP	Hsp90	MESH:D000255	855836(Tax:4932)	Chemical	Gene	binding|compound|START_ENTITY dependent|nmod|binding dependent|nsubj|function function|nmod|END_ENTITY	In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis .
7876552	0	ATP	0,3	IL-1	27,31	ATP	IL-1	MESH:D000255	111343(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|release release|nmod|END_ENTITY	ATP induces the release of IL-1 from LPS-primed cells in vivo .
12761889	0	ATP	0,3	IL-1beta	29,37	ATP	IL-1beta	MESH:D000255	3553	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	ATP modulates load-inducible IL-1beta , COX_2 , and MMP-3 gene expression in human tendon cells .
14642889	7	ATP	1301,1304	IL-1beta	1254,1262	ATP	IL-1beta	MESH:D000255	3553	Chemical	Gene	containing|nmod|START_ENTITY containing|dobj|form form|compound|END_ENTITY	In contrast , gilthead seabream SAF-1 fibroblasts shed microvesicles containing a 22 kDa IL-1beta form within 30 min of activation with ATP .
21437011	0	ATP	56,59	IL-1beta	32,40	ATP	IL-1beta	MESH:D000255	16176(Tax:10090)	Chemical	Gene	release|acl|START_ENTITY release|nmod|END_ENTITY	Ivermectin-dependent release of IL-1beta in response to ATP by peritoneal macrophages from P2X -LRB- 7 -RRB- - KO mice .
12626548	0	ATP	98,101	IL-2	13,17	ATP	IL-2	MESH:D000255	3558	Chemical	Gene	requires|dobj|START_ENTITY requires|nsubj|Secretion Secretion|nmod|END_ENTITY	Secretion of IL-2 and IFN-gamma , but not IL-4 , by antigen-specific T cells requires extracellular ATP .
16946718	0	ATP	14,17	IL-6	75,79	ATP	IL-6	MESH:D000255	3569	Chemical	Gene	has|nsubj|START_ENTITY has|dobj|effects effects|nmod|expression expression|nmod|END_ENTITY	Extracellular ATP has stimulatory effects on the expression and release of IL-6 via purinergic receptors in normal human epidermal keratinocytes .
19136380	0	ATP	75,78	IL-6	30,34	ATP	IL-6	MESH:D000255	24498(Tax:10116)	Chemical	Gene	duct|nmod|START_ENTITY duct|nsubj|regulation regulation|nmod|END_ENTITY	Transcriptional regulation of IL-6 in bile duct epithelia by extracellular ATP .
24022572	0	ATP	53,56	IL-6	61,65	ATP	IL-6	MESH:D000255	16193(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Exercise sensitizes skeletal muscle to extracellular ATP for IL-6 expression in mice .
24518675	0	ATP	77,80	IL-6	31,35	ATP	IL-6	MESH:D000255	24498(Tax:10116)	Chemical	Gene	induces|nmod|START_ENTITY induces|dobj|END_ENTITY	Electrical stimulation induces IL-6 in skeletal muscle through extracellular ATP by activating Ca -LRB- 2 + -RRB- signals and an IL-6 autocrine loop .
26030257	0	ATP	67,70	IL-6	36,40	ATP	IL-6	MESH:D000255	3569	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|Production Production|compound|END_ENTITY	Autocrine Regulation of UVA-Induced IL-6 Production via Release of ATP and Activation of P2Y Receptors .
19303321	0	ATP	14,17	IL-8	52,56	ATP	IL-8	MESH:D000255	3576	Chemical	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	Extracellular ATP and P2 receptors are required for IL-8 to induce neutrophil migration .
22446326	0	ATP	73,76	IRE1	50,54	ATP	IRE1	MESH:D000255	2081	Chemical	Gene	requires|dobj|START_ENTITY requires|nsubj|END_ENTITY	Binding of human BiP to the ER stress transducers IRE1 and PERK requires ATP .
11850664	0	ATP	56,59	Insulin	81,88	ATP	Insulin	MESH:D000255	3630	Chemical	Gene	START_ENTITY|nmod|Regulation Regulation|nmod|Secretion Secretion|compound|END_ENTITY	Involvement of Elevated Intracellular and Extracellular ATP in the Regulation of Insulin Secretion : Therapeutic Targets in Non-Insulin-Dependent_Diabetes_Mellitus .
16300674	0	ATP	61,64	Insulin	0,7	ATP	Insulin	MESH:D000255	3630	Chemical	Gene	rates|nmod|START_ENTITY relationship|nmod|rates induces|dobj|relationship induces|nsubj|END_ENTITY	Insulin induces a positive relationship between the rates of ATP and glycogen changes in isolated rat liver in presence of glucose ; a 31P and 13C NMR study .
19412833	0	ATP	36,39	Insulin	0,7	ATP	Insulin	MESH:D000255	3630	Chemical	Gene	release|compound|START_ENTITY inhibits|dobj|release inhibits|nsubj|END_ENTITY	Insulin inhibits low oxygen-induced ATP release from human erythrocytes : implication for vascular control .
17259336	0	ATP	36,39	Insulin-degrading_enzyme	0,24	ATP	Insulin-degrading enzyme	MESH:D000255	25700(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|hydrolyzes hydrolyzes|amod|END_ENTITY	Insulin-degrading_enzyme hydrolyzes ATP .
25578963	0	ATP	4,7	Lsh	57,60	ATP	Lsh	MESH:D000255	3070	Chemical	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	The ATP binding site of the chromatin remodeling homolog Lsh is required for nucleosome density and de novo DNA methylation at repeat sequences .
23941770	0	ATP	14,17	MMP-1	40,45	ATP	MMP-1	MESH:D000255	4312	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Extracellular ATP inhibits IL-1-induced MMP-1 expression through the action of CD39/nucleotidase triphosphate dephosphorylase-1 on human gingival fibroblasts .
16361361	0	ATP	0,3	MMP-2	15,20	ATP	MMP-2	MESH:D000255	4313	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|compound|END_ENTITY	ATP stimulates MMP-2 release from human aortic smooth muscle cells via JNK signaling pathway .
14523003	0	ATP	0,3	MMP-9	43,48	ATP	MMP-9	MESH:D000255	4318	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|expression expression|compound|END_ENTITY	ATP potentiates interleukin-1_beta-induced MMP-9 expression in mesangial cells via recruitment of the ELAV protein HuR .
11358378	0	ATP	21,24	MRP1	58,62	ATP	MRP1	MESH:D000255	8714	Chemical	Gene	proteins|compound|START_ENTITY proteins|dep|END_ENTITY	Erythrocyte membrane ATP binding cassette -LRB- ABC -RRB- proteins : MRP1 and CFTR as well as CD39 -LRB- ecto-apyrase -RRB- involved in RBC ATP transport and elevated blood plasma ATP of cystic_fibrosis .
17536492	0	ATP	75,78	Mg2	80,83	ATP	Mg2	MESH:D000255	4589	Chemical	Gene	START_ENTITY|appos|+ +|compound|END_ENTITY	Comparison between measured and calculated ionised concentrations in Mg2 + / ATP , Mg2 + / EDTA and Ca2 + / EGTA buffers ; influence of changes in temperature , pH and pipetting errors on the ionised concentrations .
20007690	0	ATP	32,35	MicroRNA-15b	0,12	ATP	MicroRNA-15b	MESH:D000255	100314150(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY modulates|dobj|levels modulates|nsubj|END_ENTITY	MicroRNA-15b modulates cellular ATP levels and degenerates mitochondria via Arl2 in neonatal rat cardiac myocytes .
9412459	0	ATP	14,17	NF-kappaB	115,124	ATP	NF-kappaB	MESH:D000255	4790	Chemical	Gene	activates|nsubj|START_ENTITY activates|advcl|targeting targeting|dobj|p65 p65|amod|END_ENTITY	Extracellular ATP activates transcription factor NF-kappaB through the P2Z purinoreceptor by selectively targeting NF-kappaB p65 .
9412459	0	ATP	14,17	NF-kappaB	49,58	ATP	NF-kappaB	MESH:D000255	4790	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Extracellular ATP activates transcription factor NF-kappaB through the P2Z purinoreceptor by selectively targeting NF-kappaB p65 .
8132605	0	ATP	0,3	NHE-1	18,23	ATP	NHE-1	MESH:D000255	6548	Chemical	Gene	dependence|compound|START_ENTITY dependence|nmod|END_ENTITY	ATP dependence of NHE-1 , the ubiquitous isoform of the Na + / H + antiporter .
18160710	0	ATP	0,3	NLRP12	25,31	ATP	NLRP12	MESH:D000255	91662	Chemical	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	ATP binding by monarch-1 / NLRP12 is critical for its inhibitory function .
23316199	0	ATP	0,3	NLRP3	40,45	ATP	NLRP3	MESH:D000255	114548	Chemical	Gene	release|compound|START_ENTITY release|acl|signaling signaling|nmod|activation activation|compound|END_ENTITY	ATP release and purinergic signaling in NLRP3 inflammasome activation .
26143398	0	ATP	0,3	NLRP7	15,20	ATP	NLRP7	MESH:D000255	199713	Chemical	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	ATP binding by NLRP7 is required for inflammasome activation in response to bacterial lipopeptides .
19808682	0	ATP	71,74	NPPB	45,49	ATP	NPPB	MESH:D000255	4879	Chemical	Gene	release|compound|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	5-Nitro-2 - -LRB- 3-phenylpropylamino -RRB- benzoic_acid -LRB- NPPB -RRB- stimulates cellular ATP release through exocytosis of ATP-enriched vesicles .
26358809	0	ATP	0,3	NS3	14,17	ATP	NS3	MESH:D000255	3845	Chemical	Gene	interaction|compound|START_ENTITY interaction|compound|END_ENTITY	ATP dependent NS3 helicase interaction with RNA : insights from molecular simulations .
22386494	0	ATP	141,144	Nerve_growth_factor	0,19	ATP	Nerve growth factor	MESH:D000255	310738(Tax:10116)	Chemical	Gene	require|dobj|START_ENTITY require|nsubj|END_ENTITY	Nerve_growth_factor and brain-derived_neurotrophic_factor but not granulocyte_colony-stimulating_factor , nimodipine and dizocilpine , require ATP for neuroprotective activity after oxygen-glucose deprivation of primary neurons .
8810915	0	ATP	59,62	Oligomycin_sensitivity_conferring_protein	0,41	ATP	Oligomycin sensitivity conferring protein	MESH:D000255	281640(Tax:9913)	Chemical	Gene	synthase|compound|START_ENTITY END_ENTITY|nmod|synthase	Oligomycin_sensitivity_conferring_protein of mitochondrial ATP synthase : deletions in the N-terminal end cause defects in interactions with F1 , while deletions in the C-terminal end cause defects in interactions with F0 .
10529234	0	ATP	5,8	P-glycoprotein	24,38	ATP	P-glycoprotein	MESH:D000255	5243	Chemical	Gene	sites|compound|START_ENTITY sites|nmod|END_ENTITY	Both ATP sites of human P-glycoprotein are essential but not symmetric .
10716986	0	ATP	31,34	P-glycoprotein	125,139	ATP	P-glycoprotein	MESH:D000255	5243	Chemical	Gene	requirement|nmod|START_ENTITY Evidence|nmod|requirement hydrolysis|nsubj|Evidence hydrolysis|nmod|turnover turnover|nmod|cycle cycle|nmod|END_ENTITY	Evidence for a requirement for ATP hydrolysis at two distinct steps during a single turnover of the catalytic cycle of human P-glycoprotein .
10962093	0	ATP	107,110	P-glycoprotein	31,45	ATP	P-glycoprotein	MESH:D000255	5243	Chemical	Gene	hydrolysis|compound|START_ENTITY analysis|nmod|hydrolysis demonstrates|nsubj|analysis unequal|parataxis|demonstrates unequal|nsubj|sites sites|nmod|END_ENTITY	Two transport binding sites of P-glycoprotein are unequal yet contingent : initial rate kinetic analysis by ATP hydrolysis demonstrates intersite dependence .
11009602	0	ATP	52,55	P-glycoprotein	22,36	ATP	P-glycoprotein	MESH:D000255	5243	Chemical	Gene	binding|compound|START_ENTITY altered|nmod|binding altered|nsubjpass|sites sites|nmod|END_ENTITY	Drug binding sites on P-glycoprotein are altered by ATP binding prior to nucleotide hydrolysis .
11154703	0	ATP	43,46	P-glycoprotein	67,81	ATP	P-glycoprotein	MESH:D000255	5243	Chemical	Gene	cycle|nmod|START_ENTITY Characterization|nmod|cycle hydrolysis|nsubj|Characterization hydrolysis|nmod|END_ENTITY	Characterization of the catalytic cycle of ATP hydrolysis by human P-glycoprotein .
11429407	0	ATP	121,124	P-glycoprotein	44,58	ATP	P-glycoprotein	MESH:D000255	5243	Chemical	Gene	hydrolysis|compound|START_ENTITY altered|nmod|hydrolysis altered|nsubjpass|Cross-linking Cross-linking|nmod|END_ENTITY	Cross-linking of human multidrug resistance P-glycoprotein by the substrate , tris - -LRB- 2-maleimidoethyl -RRB- amine , is altered by ATP hydrolysis .
11451943	0	ATP	65,68	P-glycoprotein	89,103	ATP	P-glycoprotein	MESH:D000255	5243	Chemical	Gene	hydrolysis|compound|START_ENTITY stimulated|dobj|hydrolysis stimulated|nmod|END_ENTITY	Evidence for the vectorial nature of drug -LRB- substrate -RRB- - stimulated ATP hydrolysis by human P-glycoprotein .
12047375	0	ATP	11,14	P-glycoprotein	52,66	ATP	P-glycoprotein	MESH:D000255	5243	Chemical	Gene	depletion|compound|START_ENTITY Effects|nmod|depletion Effects|nmod|conformation conformation|amod|END_ENTITY	Effects of ATP depletion and phosphate analogues on P-glycoprotein conformation in live cells .
12437356	0	ATP	116,119	P-glycoprotein	140,154	ATP	P-glycoprotein	MESH:D000255	5243	Chemical	Gene	hydrolysis|compound|START_ENTITY hydrolysis|nmod|END_ENTITY	Importance of the conserved Walker B glutamate residues , 556 and 1201 , for the completion of the catalytic cycle of ATP hydrolysis by human P-glycoprotein -LRB- ABCB1 -RRB- .
14596601	0	ATP	79,82	P-glycoprotein	135,149	ATP	P-glycoprotein	MESH:D000255	67078(Tax:10090)	Chemical	Gene	hydrolysis|compound|START_ENTITY suggests|dobj|hydrolysis suggests|nmod|nucleotide-binding_domains nucleotide-binding_domains|nmod|END_ENTITY	Analysis of catalytic carboxylate mutants E552Q and E1197Q suggests asymmetric ATP hydrolysis by the two nucleotide-binding_domains of P-glycoprotein .
15964250	0	ATP	36,39	P-glycoprotein	0,14	ATP	P-glycoprotein	MESH:D000255	5243	Chemical	Gene	START_ENTITY|nsubj|increases increases|amod|END_ENTITY	P-glycoprotein expression increases ATP release in respiratory cystic_fibrosis cells .
16042402	0	ATP	0,3	P-glycoprotein	133,147	ATP	P-glycoprotein	MESH:D000255	5243	Chemical	Gene	hydrolysis|compound|START_ENTITY promotes|nsubj|hydrolysis ends|dep|promotes ends|nsubj|1 1|nmod|END_ENTITY	ATP hydrolysis promotes interactions between the extracellular ends of transmembrane segments 1 and 11 of human multidrug resistance P-glycoprotein .
16463278	0	ATP	81,84	P-glycoprotein	52,66	ATP	P-glycoprotein	MESH:D000255	5243	Chemical	Gene	absence|nmod|START_ENTITY Predicting|nmod|absence Predicting|dobj|structure structure|nmod|END_ENTITY	Predicting the three-dimensional structure of human P-glycoprotein in absence of ATP by computational techniques embodying crosslinking data : insight into the mechanism of ligand migration and binding sites .
16489767	0	ATP	86,89	P-glycoprotein	105,119	ATP	P-glycoprotein	MESH:D000255	5243	Chemical	Gene	sites|compound|START_ENTITY sites|nmod|END_ENTITY	Modulator-induced interference in functional cross talk between the substrate and the ATP sites of human P-glycoprotein .
16505485	0	ATP	51,54	P-glycoprotein	134,148	ATP	P-glycoprotein	MESH:D000255	5243	Chemical	Gene	hydrolysis|compound|START_ENTITY requirement|nmod|hydrolysis bypasses|dobj|requirement bypasses|advcl|regenerating regenerating|dobj|conformation conformation|nmod|END_ENTITY	Allosteric modulation bypasses the requirement for ATP hydrolysis in regenerating low affinity transition state conformation of human P-glycoprotein .
16768456	0	ATP	48,51	P-glycoprotein	67,81	ATP	P-glycoprotein	MESH:D000255	5243	Chemical	Gene	sites|compound|START_ENTITY sites|nmod|END_ENTITY	The conserved tyrosine residues 401 and 1044 in ATP sites of human P-glycoprotein are critical for ATP binding and hydrolysis : evidence for a conserved subdomain , the A-loop in the ATP-binding_cassette .
16768456	0	ATP	99,102	P-glycoprotein	67,81	ATP	P-glycoprotein	MESH:D000255	5243	Chemical	Gene	critical|nmod|START_ENTITY critical|nsubj|residues residues|nmod|sites sites|nmod|END_ENTITY	The conserved tyrosine residues 401 and 1044 in ATP sites of human P-glycoprotein are critical for ATP binding and hydrolysis : evidence for a conserved subdomain , the A-loop in the ATP-binding_cassette .
16800628	0	ATP	122,125	P-glycoprotein	15,29	ATP	P-glycoprotein	MESH:D000255	5243	Chemical	Gene	state|compound|START_ENTITY site|nmod|state drug|nmod|site coupling|nmod|drug Stimulation|dep|coupling Stimulation|nmod|ATPase ATPase|compound|END_ENTITY	Stimulation of P-glycoprotein ATPase by analogues of tetramethylrosamine : coupling of drug binding at the `` R '' site to the ATP hydrolysis transition state .
17237262	0	ATP	67,70	P-glycoprotein	20,34	ATP	P-glycoprotein	MESH:D000255	5243	Chemical	Gene	energy|nmod|START_ENTITY harnesses|dobj|energy harnesses|nsubj|END_ENTITY	About a switch : how P-glycoprotein -LRB- ABCB1 -RRB- harnesses the energy of ATP binding and hydrolysis to do mechanical work .
17988154	0	ATP	157,160	P-glycoprotein	37,51	ATP	P-glycoprotein	MESH:D000255	5243	Chemical	Gene	analogue|nmod|START_ENTITY evidence|appos|analogue cycle|dep|evidence cycle|nmod|hydrolysis hydrolysis|nmod|END_ENTITY	Catalytic cycle of ATP hydrolysis by P-glycoprotein : evidence for formation of the E.S reaction intermediate with ATP-gamma-S , a nonhydrolyzable analogue of ATP .
17988154	0	ATP	19,22	P-glycoprotein	37,51	ATP	P-glycoprotein	MESH:D000255	5243	Chemical	Gene	hydrolysis|compound|START_ENTITY hydrolysis|nmod|END_ENTITY	Catalytic cycle of ATP hydrolysis by P-glycoprotein : evidence for formation of the E.S reaction intermediate with ATP-gamma-S , a nonhydrolyzable analogue of ATP .
18275155	0	ATP	0,3	P-glycoprotein	17,31	ATP	P-glycoprotein	MESH:D000255	610926(Tax:9615)	Chemical	Gene	occlusion|nsubj|START_ENTITY occlusion|nmod|END_ENTITY	ATP occlusion by P-glycoprotein as a surrogate measure for drug coupling .
21452853	0	ATP	132,135	P-glycoprotein	42,56	ATP	P-glycoprotein	MESH:D000255	5243	Chemical	Gene	analogue|compound|START_ENTITY evidence|nmod|analogue adenosine|dobj|evidence adenosine|nsubj|Inhibition Inhibition|acl|multidrug multidrug|ccomp|function function|nsubj|END_ENTITY	Inhibition of multidrug resistance-linked P-glycoprotein -LRB- ABCB1 -RRB- function by 5 ' - fluorosulfonylbenzoyl_5 ' - adenosine : evidence for an ATP analogue that interacts with both drug-substrate-and nucleotide-binding sites .
23750858	0	ATP	38,41	P-glycoprotein	72,86	ATP	P-glycoprotein	MESH:D000255	67078(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Evaluation of the contribution of the ATP binding cassette transporter , P-glycoprotein , to in vivo cholesterol homeostasis .
24506763	0	ATP	21,24	P-glycoprotein	49,63	ATP	P-glycoprotein	MESH:D000255	5243	Chemical	Gene	hydrolysis|compound|START_ENTITY dynamics|nmod|hydrolysis catalyzed|nsubj|dynamics catalyzed|nmod|END_ENTITY	Reaction dynamics of ATP hydrolysis catalyzed by P-glycoprotein .
25600711	0	ATP	74,77	P-glycoprotein	45,59	ATP	P-glycoprotein	MESH:D000255	5243	Chemical	Gene	Binding|compound|START_ENTITY Models|nmod|Binding Models|nmod|END_ENTITY	Equilibrated Atomic Models of Outward-Facing P-glycoprotein and Effect of ATP Binding on Structural Dynamics .
25637762	0	ATP	78,81	P-glycoprotein	0,14	ATP	P-glycoprotein	MESH:D000255	5243	Chemical	Gene	consumption|compound|START_ENTITY Stimulation|nmod|consumption interactions|dep|Stimulation interactions|amod|END_ENTITY	P-glycoprotein interactions of novel psychoactive substances - Stimulation of ATP consumption and transport across Caco-2 monolayers .
26686578	0	ATP	57,60	P-glycoprotein	101,115	ATP	P-glycoprotein	MESH:D000255	5243	Chemical	Gene	Hydrolysis|compound|START_ENTITY Hydrolysis|nmod|END_ENTITY	Drug-Protein Hydrogen Bonds Govern the Inhibition of the ATP Hydrolysis of the Multidrug Transporter P-glycoprotein .
8621717	0	ATP	102,105	P-glycoprotein	29,43	ATP	P-glycoprotein	MESH:D000255	5243	Chemical	Gene	hydrolysis|compound|START_ENTITY transport|nmod|hydrolysis reveals|dobj|transport reveals|nsubj|reconstitution reconstitution|nmod|END_ENTITY	Functional reconstitution of P-glycoprotein reveals an apparent near stoichiometric drug transport to ATP hydrolysis .
9441944	0	ATP	0,3	P-glycoprotein	39,53	ATP	P-glycoprotein	MESH:D000255	5243	Chemical	Gene	hydrolysis|nsubj|START_ENTITY hydrolysis|nmod|END_ENTITY	ATP hydrolysis cycles and mechanism in P-glycoprotein and CFTR .
9652413	0	ATP	56,59	P-glycoprotein	74,88	ATP	P-glycoprotein	MESH:D000255	5243	Chemical	Gene	transport|nmod|START_ENTITY coupling|nmod|transport Stoichiometry|nmod|coupling hydrolysis|nsubj|Stoichiometry hydrolysis|nmod|END_ENTITY	Stoichiometry of coupling of rhodamine_123 transport to ATP hydrolysis by P-glycoprotein .
9753453	0	ATP	76,79	P-glycoprotein	53,67	ATP	P-glycoprotein	MESH:D000255	5243	Chemical	Gene	START_ENTITY|nsubj|flexibility flexibility|nmod|region region|nmod|permits permits|amod|END_ENTITY	Structural flexibility of the linker region of human P-glycoprotein permits ATP hydrolysis and drug transport .
14699168	0	ATP	0,3	P2X1	21,25	ATP	P2X1	MESH:D000255	5023	Chemical	Gene	binding|nsubj|START_ENTITY binding|nmod|receptors receptors|compound|END_ENTITY	ATP binding at human P2X1 receptors .
16000618	0	ATP	28,31	P2X1	70,74	ATP	P2X1	MESH:D000255	25505(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	Dual presynaptic control by ATP of glutamate release via facilitatory P2X1 , P2X2/3 , and P2X3 and inhibitory P2Y1 , P2Y2 , and/or P2Y4 receptors in the rat hippocampus .
20660288	0	ATP	32,35	P2X1	58,62	ATP	P2X1	MESH:D000255	5023	Chemical	Gene	release|compound|START_ENTITY regulate|nsubj|release regulate|nmod|receptors receptors|compound|END_ENTITY	Pannexin-1 hemichannel-mediated ATP release together with P2X1 and P2X4 receptors regulate T-cell activation at the immune synapse .
10809182	0	ATP	14,17	P2X2	60,64	ATP	P2X2	MESH:D000255	114115(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|apoptosis apoptosis|nmod|receptors receptors|nummod|END_ENTITY	Extracellular ATP inhibits starvation-induced apoptosis via P2X2 receptors in differentiated rat pheochromocytoma PC12 cells .
12844512	0	ATP	53,56	P2X2	82,86	ATP	P2X2	MESH:D000255	114115(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|acl|containing containing|dobj|subunit subunit|compound|END_ENTITY	Dehydroepiandrosterone potentiates native ionotropic ATP receptors containing the P2X2 subunit in rat sensory neurones .
15905416	0	ATP	66,69	P2X2	0,4	ATP	P2X2	MESH:D000255	114115(Tax:10116)	Chemical	Gene	Ca2|acl|START_ENTITY essential|nmod|Ca2 essential|nsubj|receptors receptors|compound|END_ENTITY	P2X2 receptors are essential for -LSB- Ca2 + -RSB- i increases in response to ATP in cultured rat myenteric neurons .
15961431	0	ATP	139,142	P2X2	0,4	ATP	P2X2	MESH:D000255	231602(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY mediating|dobj|effects reveal|advcl|mediating reveal|nsubj|mice mice|nummod|END_ENTITY	P2X2 knockout mice and P2X2/P2X3 double knockout mice reveal a role for the P2X2 receptor subunit in mediating multiple sensory effects of ATP .
15961431	0	ATP	139,142	P2X2	76,80	ATP	P2X2	MESH:D000255	231602(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY mediating|dobj|effects reveal|advcl|mediating reveal|dobj|role role|nmod|subunit subunit|compound|END_ENTITY	P2X2 knockout mice and P2X2/P2X3 double knockout mice reveal a role for the P2X2 receptor subunit in mediating multiple sensory effects of ATP .
15988588	0	ATP	0,3	P2X2	88,92	ATP	P2X2	MESH:D000255	22953	Chemical	Gene	elicits|compound|START_ENTITY inward|nsubj|elicits inward|nmod|terminals terminals|nmod|receptors receptors|compound|END_ENTITY	ATP elicits inward currents in isolated vasopressinergic neurohypophysial terminals via P2X2 and P2X3 receptors .
17664346	0	ATP	56,59	P2X2	17,21	ATP	P2X2	MESH:D000255	114115(Tax:10116)	Chemical	Gene	pulses|nmod|START_ENTITY receptors|nmod|pulses receptors|compound|END_ENTITY	Responses of rat P2X2 receptors to ultrashort pulses of ATP provide insights into ATP binding and channel gating .
17664346	0	ATP	82,85	P2X2	17,21	ATP	P2X2	MESH:D000255	114115(Tax:10116)	Chemical	Gene	binding|compound|START_ENTITY provide|nmod|binding provide|nsubj|Responses Responses|nmod|receptors receptors|compound|END_ENTITY	Responses of rat P2X2 receptors to ultrashort pulses of ATP provide insights into ATP binding and channel gating .
18194442	0	ATP	61,64	P2X2	99,103	ATP	P2X2	MESH:D000255	114115(Tax:10116)	Chemical	Gene	action|compound|START_ENTITY action|nmod|receptors receptors|compound|END_ENTITY	Contribution of extracellular negatively charged residues to ATP action and zinc modulation of rat P2X2 receptors .
20004677	0	ATP	52,55	P2X2	36,40	ATP	P2X2	MESH:D000255	22953	Chemical	Gene	START_ENTITY|nsubj|potentiation potentiation|nmod|ionotropic ionotropic|compound|END_ENTITY	Selective potentiation of homomeric P2X2 ionotropic ATP receptors by a fast non-genomic action of progesterone .
21306580	0	ATP	51,54	P2X2	58,62	ATP	P2X2	MESH:D000255	231602(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nmod|cells cells|compound|END_ENTITY	Colchicine inhibits cationic dye uptake induced by ATP in P2X2 and P2X7_receptor-expressing cells : implications for its therapeutic action .
22090499	0	ATP	35,38	P2X2	9,13	ATP	P2X2	MESH:D000255	114115(Tax:10116)	Chemical	Gene	sensors|compound|START_ENTITY sensors|nsubj|receptors receptors|compound|END_ENTITY	Neuronal P2X2 receptors are mobile ATP sensors that explore the plasma membrane when activated .
22828800	0	ATP	58,61	P2X2	23,27	ATP	P2X2	MESH:D000255	22953	Chemical	Gene	molecules|compound|START_ENTITY Activation|nmod|molecules Activation|nmod|receptors receptors|compound|END_ENTITY	Activation of trimeric P2X2 receptors by fewer than three ATP molecules .
23041661	0	ATP	51,54	P2X2	101,105	ATP	P2X2	MESH:D000255	114115(Tax:10116)	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|transition transition|nmod|receptor receptor|compound|END_ENTITY	Salt bridge switching from Arg290/Glu167 _ to_Arg290 / ATP promotes the closed-to-open transition of the P2X2 receptor .
23112811	0	ATP	140,143	P2X2	36,40	ATP	P2X2	MESH:D000255	114115(Tax:10116)	Chemical	Gene	allows|nmod|START_ENTITY allows|nsubj|modification modification|nmod|receptors receptors|compound|END_ENTITY	Covalent modification of mutant rat P2X2 receptors with a thiol-reactive fluorophore allows channel activation by zinc or acidic pH without ATP .
9682808	0	ATP	26,29	P2X2	21,25	ATP	P2X2	MESH:D000255	114115(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Novel variant of the P2X2 ATP receptor from the guinea_pig organ of Corti .
9786492	0	ATP	269,272	P2X2	22,26	ATP	P2X2	MESH:D000255	114115(Tax:10116)	Chemical	Gene	application|compound|START_ENTITY termination|nmod|application followed|nmod|termination current|acl|followed produces|dobj|current produces|ccomp|caused caused|nsubj|Fading Fading|nmod|currents currents|nummod|END_ENTITY	Fading and rebound of P2X2 currents at millimolar ATP concentrations caused by low pH. When ATP is applied at high concentrations -LRB- above 1 mM -RRB- to PC12 cells , it produces a rapidly desensitizing peak current followed by a rebound of the current after termination of the ATP application .
9786492	0	ATP	50,53	P2X2	22,26	ATP	P2X2	MESH:D000255	114115(Tax:10116)	Chemical	Gene	concentrations|compound|START_ENTITY currents|nmod|concentrations currents|nummod|END_ENTITY	Fading and rebound of P2X2 currents at millimolar ATP concentrations caused by low pH. When ATP is applied at high concentrations -LRB- above 1 mM -RRB- to PC12 cells , it produces a rapidly desensitizing peak current followed by a rebound of the current after termination of the ATP application .
9786492	0	ATP	92,95	P2X2	22,26	ATP	P2X2	MESH:D000255	114115(Tax:10116)	Chemical	Gene	applied|nsubjpass|START_ENTITY caused|advcl|applied caused|nsubj|Fading Fading|nmod|currents currents|nummod|END_ENTITY	Fading and rebound of P2X2 currents at millimolar ATP concentrations caused by low pH. When ATP is applied at high concentrations -LRB- above 1 mM -RRB- to PC12 cells , it produces a rapidly desensitizing peak current followed by a rebound of the current after termination of the ATP application .
11466438	0	ATP	74,77	P2X3	0,4	ATP	P2X3	MESH:D000255	228139(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY reveal|dobj|role reveal|nsubj|mice mice|nummod|END_ENTITY	P2X3 knock-out mice reveal a major sensory role for urothelially released ATP .
16763024	0	ATP	24,27	P2X3	28,32	ATP	P2X3	MESH:D000255	5024	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Delayed upregulation of ATP P2X3 receptors of trigeminal sensory neurons by calcitonin_gene-related_peptide .
18768143	0	ATP	18,21	P2X3	34,38	ATP	P2X3	MESH:D000255	81739(Tax:10116)	Chemical	Gene	decelerates|nsubj|START_ENTITY decelerates|dobj|kinetics kinetics|nummod|END_ENTITY	Nanomolar ambient ATP decelerates P2X3 receptor kinetics .
21195750	0	ATP	23,26	P2X3	27,31	ATP	P2X3	MESH:D000255	81739(Tax:10116)	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Noradrenaline enhances ATP P2X3 receptor expression in dorsal root ganglion neurons of rats .
22616675	0	ATP	25,28	P2X3	20,24	ATP	P2X3	MESH:D000255	81739(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Potentiation of the P2X3 ATP receptor by PAR-2 in rat dorsal root ganglia neurons , through protein_kinase-dependent mechanisms , contributes to inflammatory pain .
24391544	0	ATP	27,30	P2X3	45,49	ATP	P2X3	MESH:D000255	81739(Tax:10116)	Chemical	Gene	promise|nmod|START_ENTITY antagonism|nsubj|promise antagonism|nmod|receptors receptors|nummod|END_ENTITY	The therapeutic promise of ATP antagonism at P2X3 receptors in respiratory and urological_disorders .
14978347	0	ATP	0,3	P2X4	129,133	ATP	P2X4	MESH:D000255	29659(Tax:10116)	Chemical	Gene	signaling|amod|START_ENTITY signaling|dep|involvement involvement|nmod|END_ENTITY	ATP - and adenosine-mediated signaling in the central nervous system : chronic pain and microglia : involvement of the ATP receptor P2X4 .
20331601	0	ATP	43,46	P2X4	56,60	ATP	P2X4	MESH:D000255	18438(Tax:10090)	Chemical	Gene	action|nmod|START_ENTITY block|dobj|action block|nmod|receptor receptor|compound|END_ENTITY	Amitriptyline does not block the action of ATP at human P2X4 receptor .
22753954	0	ATP	0,3	P2X4	44,48	ATP	P2X4	MESH:D000255	5025	Chemical	Gene	release|compound|START_ENTITY release|acl|signaling signaling|nmod|activation activation|compound|END_ENTITY	ATP release and autocrine signaling through P2X4 receptors regulate y T cell activation .
9037385	0	ATP	34,37	P2X4	29,33	ATP	P2X4	MESH:D000255	29659(Tax:10116)	Chemical	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	Cellular distribution of the P2X4 ATP receptor mRNA in the brain and non-neuronal organs of rats .
9736638	0	ATP	75,78	P2X4	8,12	ATP	P2X4	MESH:D000255	5025	Chemical	Gene	receptor|compound|START_ENTITY coassemble|nmod|receptor coassemble|nsubj|END_ENTITY	Central P2X4 and P2X6 channel subunits coassemble into a novel heteromeric ATP receptor .
14978243	0	ATP	29,32	P2X7	24,28	ATP	P2X7	MESH:D000255	5027	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Selective knock-down of P2X7 ATP receptor function by dominant-negative subunits .
15070812	0	ATP	0,3	P2X7	18,22	ATP	P2X7	MESH:D000255	18439(Tax:10090)	Chemical	Gene	downregulates|compound|START_ENTITY END_ENTITY|nsubj|downregulates	ATP downregulates P2X7 and inhibits osteoclast formation in RAW cells .
15896293	0	ATP	73,76	P2X7	68,72	ATP	P2X7	MESH:D000255	5027	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Identification and characterization of splice variants of the human P2X7 ATP channel .
15901833	0	ATP	29,32	P2X7	24,28	ATP	P2X7	MESH:D000255	5027	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Basal activation of the P2X7 ATP receptor elevates mitochondrial calcium and potential , increases cellular ATP levels , and promotes serum-independent growth .
15925905	0	ATP	9,12	P2X7	4,8	ATP	P2X7	MESH:D000255	18439(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	The P2X7 ATP receptor in the kidney : a matter of life or death ?
16452661	0	ATP	23,26	P2X7	0,4	ATP	P2X7	MESH:D000255	5027	Chemical	Gene	release|compound|START_ENTITY release|compound|END_ENTITY	P2X7 receptors mediate ATP release and amplification of astrocytic intercellular Ca2 + signaling .
17384268	0	ATP	8,11	P2X7	67,71	ATP	P2X7	MESH:D000255	5027	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|stimulation stimulation|compound|END_ENTITY	Role of ATP in trauma-associated cytokine release and apoptosis by P2X7 ion channel stimulation .
17675190	0	ATP	52,55	P2X7	47,51	ATP	P2X7	MESH:D000255	18439(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Differential regulation of microglial P2X4 and P2X7 ATP receptors following LPS-induced activation .
18336732	0	ATP	19,22	P2X7	75,79	ATP	P2X7	MESH:D000255	18439(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|parataxis|involvement involvement|nmod|receptors receptors|compound|END_ENTITY	Periodate oxidized ATP -LRB- oATP -RRB- reduces hyperalgesia in mice : involvement of P2X7 receptors and implications for therapy .
21747211	0	ATP	50,53	P2X7	76,80	ATP	P2X7	MESH:D000255	5027	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|receptors receptors|nummod|END_ENTITY	Selective upregulation of Per1 mRNA expression by ATP through activation of P2X7 purinergic receptors expressed in microglial cells .
21819977	0	ATP	53,56	P2X7	0,4	ATP	P2X7	MESH:D000255	100379234(Tax:10141)	Chemical	Gene	induced|nmod|START_ENTITY currents|acl|induced contribute|nmod|currents contribute|nsubj|receptors receptors|compound|END_ENTITY	P2X7 receptors contribute to the currents induced by ATP in guinea_pig intestinal myenteric neurons .
22948816	0	ATP	14,17	P2X7	79,83	ATP	P2X7	MESH:D000255	18439(Tax:10090)	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|nmod|purinoceptors purinoceptors|nummod|END_ENTITY	Extracellular ATP mediates mast cell-dependent intestinal_inflammation through P2X7 purinoceptors .
22984079	0	ATP	0,3	P2X7	92,96	ATP	P2X7	MESH:D000255	5027	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|receptor receptor|compound|END_ENTITY	ATP induces protein arginine deiminase 2-dependent citrullination in mast cells through the P2X7 purinergic receptor .
24851271	0	ATP	19,22	P2X7	14,18	ATP	P2X7	MESH:D000255	5027	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Expression of P2X7 ATP receptor mediating the IL8 and CCL20 release in human periodontal ligament stem cells .
26060214	0	ATP	14,17	P2X7	61,65	ATP	P2X7	MESH:D000255	18439(Tax:10090)	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|sepsis sepsis|nmod|receptors receptors|compound|END_ENTITY	Extracellular ATP protects against sepsis through macrophage P2X7 purinergic receptors by enhancing intracellular bacterial killing .
9038151	0	ATP	19,22	P2X7	33,37	ATP	P2X7	MESH:D000255	5027	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	The permeabilizing ATP receptor , P2X7 .
12417299	0	ATP	47,50	P2X7_receptor	70,83	ATP	P2X7 receptor	MESH:D000255	5027	Chemical	Gene	macrophages|nmod|START_ENTITY heterogeneity|nmod|macrophages associated|nsubjpass|heterogeneity associated|nmod|expression expression|amod|END_ENTITY	Response heterogeneity of human macrophages to ATP is associated with P2X7_receptor expression but not to polymorphisms in the P2RX7 promoter .
15304508	0	ATP	14,17	P2X7_receptor	85,98	ATP	P2X7 receptor	MESH:D000255	5027	Chemical	Gene	increases|nsubj|START_ENTITY increases|nmod|activation activation|nmod|END_ENTITY	Extracellular ATP increases cation fluxes in human erythrocytes by activation of the P2X7_receptor .
15306646	0	ATP	169,172	P2X7_receptor	120,133	ATP	P2X7 receptor	MESH:D000255	18439(Tax:10090)	Chemical	Gene	activation|dep|START_ENTITY activation|nmod|receptors receptors|nmod|fibers fibers|nmod|-3 -3|nmod:poss|agonist agonist|compound|END_ENTITY	Ecto-nucleotidases and nucleoside transporters mediate activation of adenosine receptors on hippocampal mossy fibers by P2X7_receptor agonist 2 ' -3 ' - O - -LRB- 4-benzoylbenzoyl -RRB- - ATP .
15649023	0	ATP	41,44	P2X7_receptor	66,79	ATP	P2X7 receptor	MESH:D000255	18439(Tax:10090)	Chemical	Gene	concentration|nmod|START_ENTITY caused|nmod|concentration caused|nmod|activation activation|nmod|END_ENTITY	Problems caused by high concentration of ATP on activation of the P2X7_receptor in bone marrow cells loaded with the Ca2 + fluorophore fura-2 .
15728711	0	ATP	0,3	P2X7_receptor	86,99	ATP	P2X7 receptor	MESH:D000255	5027	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	ATP stimulates GRK-3 phosphorylation and beta-arrestin-2-dependent internalization of P2X7_receptor .
15778342	0	ATP	14,17	P2X7_receptor	68,81	ATP	P2X7 receptor	MESH:D000255	18439(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Extracellular ATP induces cytokine expression and apoptosis through P2X7_receptor in murine mast cells .
19250337	0	ATP	57,60	P2X7_receptor	77,90	ATP	P2X7 receptor	MESH:D000255	5027	Chemical	Gene	START_ENTITY|nmod|ligation ligation|nmod|END_ENTITY	Neural progenitor cell death is induced by extracellular ATP via ligation of P2X7_receptor .
19748989	0	ATP	14,17	P2X7_receptor	32,45	ATP	P2X7 receptor	MESH:D000255	5027	Chemical	Gene	START_ENTITY|acl|acting acting|nmod|END_ENTITY	Extracellular ATP acting at the P2X7_receptor inhibits secretion of soluble HLA-G from human monocytes .
20522787	0	ATP	14,17	P2X7_receptor	48,61	ATP	P2X7 receptor	MESH:D000255	18439(Tax:10090)	Chemical	Gene	signal|nsubj|START_ENTITY signal|acl|activating activating|dobj|END_ENTITY	Extracellular ATP is a danger signal activating P2X7_receptor in lung_inflammation and fibrosis .
21262970	0	ATP	74,77	P2X7_receptor	33,46	ATP	P2X7 receptor	MESH:D000255	5027	Chemical	Gene	concentrations|compound|START_ENTITY sensitizing|nmod|concentrations potentiates|advcl|sensitizing potentiates|dobj|END_ENTITY	Clemastine potentiates the human P2X7_receptor by sensitizing it to lower ATP concentrations .
21812012	0	ATP	14,17	P2X7_receptor	82,95	ATP	P2X7 receptor	MESH:D000255	18439(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|CD44 CD44|acl|shedding shedding|nmod|cells cells|nmod|END_ENTITY	Extracellular ATP induces CD44 shedding from macrophage-like P388D1 cells via the P2X7_receptor .
22883563	0	ATP	35,38	P2X7_receptor	127,140	ATP	P2X7 receptor	MESH:D000255	5027	Chemical	Gene	outflow|compound|START_ENTITY outflow|dep|involvement involvement|nmod|END_ENTITY	High glucose concentration impairs ATP outflow and immunoglobulin production by human peripheral B lymphocytes : involvement of P2X7_receptor .
24905552	0	ATP	22,25	P2X7_receptor	56,69	ATP	P2X7 receptor	MESH:D000255	18439(Tax:10090)	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Tension force-induced ATP promotes osteogenesis through P2X7_receptor in osteoblasts .
25542352	0	ATP	40,43	P2X7_receptor	77,90	ATP	P2X7 receptor	MESH:D000255	18439(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|formation formation|nmod|END_ENTITY	Low-intensity_pulsed_ultrasound-induced ATP increases bone formation via the P2X7_receptor in osteoblast-like MC3T3-E1 cells .
25681768	0	ATP	14,17	P2X7_receptor	26,39	ATP	P2X7 receptor	MESH:D000255	18439(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|ccomp|decreased decreased|nsubj|activation activation|amod|END_ENTITY	Extracellular ATP induces P2X7_receptor activation in mouse Kupffer cells , leading to release of IL-1b , HMGB1 , and PGE2 , decreased MHC class I expression and necrotic cell death .
26122280	0	ATP	14,17	P2X7_receptor	116,129	ATP	P2X7 receptor	MESH:D000255	5027	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|activation activation|nmod|END_ENTITY	Extracellular ATP enhances radiation-induced brain_injury through microglial activation and paracrine signaling via P2X7_receptor .
11019833	0	ATP	22,25	P2Y1	59,63	ATP	P2Y1	MESH:D000255	5028	Chemical	Gene	analogs|compound|START_ENTITY antagonists|nsubj|analogs antagonists|nmod|purinoceptors purinoceptors|compound|END_ENTITY	Phosphate-substituted ATP analogs are antagonists at human P2Y1 purinoceptors .
12949218	0	ATP	0,3	P2Y1	59,63	ATP	P2Y1	MESH:D000255	5028	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|nmod|purinoceptor purinoceptor|compound|END_ENTITY	ATP modulates intracellular Ca2 + and firing rate through a P2Y1 purinoceptor in cane toad pacemaker cells .
17997228	0	ATP	107,110	P2Y1	61,65	ATP	P2Y1	MESH:D000255	18441(Tax:10090)	Chemical	Gene	release|compound|START_ENTITY modulators|nmod|release receptors|nmod|modulators receptors|nummod|END_ENTITY	Inhibitory purinergic transmission in mouse caecum : role for P2Y1 receptors as prejunctional modulators of ATP release .
19805741	0	ATP	14,17	P2Y1	95,99	ATP	P2Y1	MESH:D000255	5028	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|activating activating|dobj|receptors receptors|nummod|END_ENTITY	Extracellular ATP inhibits chloride channels in mature mammalian skeletal muscle by activating P2Y1 receptors .
22899721	0	ATP	0,3	P2Y1	67,71	ATP	P2Y1	MESH:D000255	5028	Chemical	Gene	Ins|compound|START_ENTITY P3-evoked|nsubj|Ins P3-evoked|nmod|muscle muscle|nmod|receptors receptors|nummod|END_ENTITY	ATP inhibits Ins -LRB- 1,4,5 -RRB- P3-evoked Ca2 + release in smooth muscle via P2Y1 receptors .
23090120	5	ATP	703,706	P2Y1	739,743	ATP	P2X4	MESH:D000255	5025	Chemical	Gene	proinflammatory|nsubj|START_ENTITY proinflammatory|dep|acting acting|nmod|P2Y6 P2Y6|nummod|END_ENTITY	ATP is a proinflammatory -LRB- acting at P2Y1 , P2Y2 , P2Y4 , P2Y6 , and P2Y12 , and at P2X4 and P2X7 receptors -RRB- , an immunosuppressant -LRB- acting at P2Y11 -RRB- , and a growth-promoting agent -LRB- acting at P2Y1 , P2Y2 , and P2X7 receptors -RRB- .
24304101	0	ATP	0,3	P2Y1	4,8	ATP	P2Y1	MESH:D000255	18441(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	ATP P2Y1 receptors control cognitive_deficits and neurotoxicity but not glial modifications induced by brain_ischemia in mice .
10839197	0	ATP	77,80	P2Y2	48,52	ATP	P2Y2	MESH:D000255	5029	Chemical	Gene	nucleotide|nmod|START_ENTITY nucleotide|nsubj|desensitization desensitization|nmod|END_ENTITY	Differential agonist-induced desensitization of P2Y2 nucleotide receptors by ATP and UTP .
12210747	0	ATP	0,3	P2Y2	103,107	ATP	P2Y2	MESH:D000255	29597(Tax:10116)	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|nmod|osteoblasts osteoblasts|dep|role role|nmod|receptor receptor|compound|END_ENTITY	ATP and UTP at low concentrations strongly inhibit bone formation by osteoblasts : a novel role for the P2Y2 receptor in bone remodeling .
14597595	0	ATP	0,3	P2Y2	89,93	ATP	P2Y2	MESH:D000255	29597(Tax:10116)	Chemical	Gene	responses|compound|START_ENTITY responses|dep|dominance dominance|nmod|receptors receptors|nummod|END_ENTITY	ATP and UTP responses of cultured rat aortic smooth muscle cells revisited : dominance of P2Y2 receptors .
16133936	0	ATP	51,54	P2Y2	17,21	ATP	P2Y2	MESH:D000255	18442(Tax:10090)	Chemical	Gene	receptor|nmod|START_ENTITY receptor|compound|END_ENTITY	Co-activation of P2Y2 receptor and TRPV channel by ATP : implications for ATP induced pain .
16133936	0	ATP	73,76	P2Y2	17,21	ATP	P2Y2	MESH:D000255	18442(Tax:10090)	Chemical	Gene	pain|compound|START_ENTITY implications|nmod|pain Co-activation|dep|implications Co-activation|nmod|receptor receptor|compound|END_ENTITY	Co-activation of P2Y2 receptor and TRPV channel by ATP : implications for ATP induced pain .
17170310	0	ATP	0,3	P2Y2	45,49	ATP	P2Y2	MESH:D000255	5029	Chemical	Gene	guides|compound|START_ENTITY neutrophil|nsubj|guides neutrophil|dobj|chemotaxis chemotaxis|nmod|receptors receptors|compound|END_ENTITY	ATP release guides neutrophil chemotaxis via P2Y2 and A3 receptors .
18434089	0	ATP	14,17	P2Y2	74,78	ATP	P2Y2	MESH:D000255	5029	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|PLC/PKC/ERK PLC/PKC/ERK|acl|signaling signaling|nmod|receptor receptor|compound|END_ENTITY	Extracellular ATP activates the PLC/PKC/ERK signaling pathway through the P2Y2 purinergic receptor leading to the induction of early growth response 1 expression and the inhibition of viability in human endometrial stromal cells .
19900397	0	ATP	0,3	P2Y2	44,48	ATP	P2Y2	MESH:D000255	18442(Tax:10090)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|nmod|receptors receptors|compound|END_ENTITY	ATP modulates transcription factors through P2Y2 and P2Y4 receptors via PKC/MAPKs and PKC/Src pathways in MCF-7 cells .
21859844	0	ATP	14,17	P2Y2	26,30	ATP	P2Y2	MESH:D000255	5029	Chemical	Gene	acts|nsubj|START_ENTITY acts|nmod|receptors receptors|nummod|END_ENTITY	Extracellular ATP acts on P2Y2 purinergic receptors to facilitate HIV-1_infection .
22415310	0	ATP	0,3	P2Y2	86,90	ATP	P2Y2	MESH:D000255	5029	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|receptors receptors|compound|END_ENTITY	ATP released from cardiac fibroblasts via connexin hemichannels activates profibrotic P2Y2 receptors .
22733659	0	ATP	136,139	P2Y2	0,4	ATP	P2Y2	MESH:D000255	29597(Tax:10116)	Chemical	Gene	amplifying|dobj|START_ENTITY role|acl|amplifying type|dep|role carotid|dobj|type opens|ccomp|carotid opens|nsubj|activation activation|nummod|END_ENTITY	P2Y2 receptor activation opens pannexin-1 channels in rat carotid body type II cells : potential role in amplifying the neurotransmitter ATP .
22993317	0	ATP	14,17	P2Y2	70,74	ATP	P2Y2	MESH:D000255	5029	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|transients transients|nmod|receptor receptor|nummod|END_ENTITY	Extracellular ATP induces cytoplasmic and nuclear Ca2 + transients via P2Y2 receptor in human biliary_epithelial_cancer cells -LRB- Mz-Cha-1 -RRB- .
23567840	0	ATP	26,29	P2Y2	95,99	ATP	P2Y2	MESH:D000255	450248(Tax:9823)	Chemical	Gene	stimulation|compound|START_ENTITY kinase|dobj|stimulation kinase|parataxis|involves involves|dobj|receptor receptor|compound|END_ENTITY	Protein kinase C-mediated ATP stimulation of Na -LRB- + -RRB- - ATPase activity in LLC-PK1 cells involves a P2Y2 and/or P2Y4 receptor .
24961145	0	ATP	40,43	P2Y2	96,100	ATP	P2Y2	MESH:D000255	5029	Chemical	Gene	START_ENTITY|nmod|growth growth|nmod|cells cells|nmod|receptor receptor|compound|END_ENTITY	The inhibitory effects of extracellular ATP on the growth of nasopharyngeal_carcinoma cells via P2Y2 receptor and osteopontin .
25713410	0	ATP	55,58	P2Y2	50,54	ATP	P2Y2	MESH:D000255	5029	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Close association of B2 bradykinin receptors with P2Y2 ATP receptors .
9716704	0	ATP	8,11	P2Y2	39,43	ATP	P2Y2	MESH:D000255	29597(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|secretion secretion|nmod|receptor receptor|compound|END_ENTITY	Luminal ATP induces K + secretion via a P2Y2 receptor in rat distal colonic mucosa .
9233643	0	ATP	14,17	P2Z_receptor	74,86	ATP	P2Z receptor	MESH:D000255	5027	Chemical	Gene	triggers|nsubj|START_ENTITY triggers|advcl|activating activating|dobj|END_ENTITY	Extracellular ATP triggers IL-1_beta release by activating the purinergic P2Z_receptor of human macrophages .
9384508	0	ATP	0,3	P2Z_receptor	31,43	ATP	P2Z receptor	MESH:D000255	5027	Chemical	Gene	START_ENTITY|appos|agonist agonist|nmod|END_ENTITY	ATP , a partial agonist for the P2Z_receptor of human lymphocytes .
9756924	0	ATP	85,88	P2x4	44,48	ATP	P2x4	MESH:D000255	29659(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|receptors receptors|amod|END_ENTITY	Expression and trans-synaptic regulation of P2x4 and P2z receptors for extracellular ATP in parotid acinar cells .
8150279	0	ATP	127,130	PDR5	175,179	ATP	PDR5	MESH:D000255	854324(Tax:4932)	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mutations in the yeast PDR3 , PDR4 , PDR7 and PDR9 pleiotropic -LRB- multiple -RRB- drug resistance loci affect the transcript level of an ATP binding cassette transporter encoding gene , PDR5 .
26834014	0	ATP	40,43	PGC-1a	0,6	ATP	PGC-1a	MESH:D000255	10891	Chemical	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	PGC-1a regulates the cell cycle through ATP and ROS in CH1 cells .
8761294	0	ATP	17,20	PKC-delta	39,48	ATP	PKC-delta	MESH:D000255	18753(Tax:10090)	Chemical	Gene	mutant|compound|START_ENTITY mutant|nmod|END_ENTITY	Expression of an ATP binding mutant of PKC-delta inhibits Sis-induced transformation of NIH3T3 cells .
11883951	0	ATP	55,58	PMP70	45,50	ATP	PMP70	MESH:D000255	25270(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|appos|transporter	Nucleotide-induced conformational changes of PMP70 , an ATP binding cassette transporter on rat liver peroxisomal membranes .
12176987	0	ATP	0,3	PMP70	91,96	ATP	PMP70	MESH:D000255	25270(Tax:10116)	Chemical	Gene	binding/hydrolysis|nsubj|START_ENTITY binding/hydrolysis|nmod|END_ENTITY	ATP binding/hydrolysis by and phosphorylation of peroxisomal ATP-binding cassette proteins PMP70 -LRB- ABCD3 -RRB- and adrenoleukodystrophy_protein -LRB- ABCD1 -RRB- .
6225432	0	ATP	30,33	PS3	83,86	ATP	PS3	MESH:D000255	448990	Chemical	Gene	synthesis|nmod|START_ENTITY END_ENTITY|nsubj|synthesis	The synthesis of enzyme-bound ATP by the F1-ATPase from the thermophilic bacterium PS3 in 50 % dimethylsulfoxide .
8654428	0	ATP	26,29	PS3	66,69	ATP	PS3	MESH:D000255	448990	Chemical	Gene	synthase|compound|START_ENTITY synthase|nmod|END_ENTITY	ATP synthesis by the F0F1 ATP synthase from thermophilic Bacillus PS3 reconstituted into liposomes with bacteriorhodopsin .
8654429	0	ATP	26,29	PS3	66,69	ATP	PS3	MESH:D000255	448990	Chemical	Gene	synthase|compound|START_ENTITY synthase|nmod|END_ENTITY	ATP synthesis by the F0F1 ATP synthase from thermophilic Bacillus PS3 reconstituted into liposomes with bacteriorhodopsin .
19213873	0	ATP	26,29	Pannexin_1	0,10	ATP	Pannexin 1	MESH:D000255	24145	Chemical	Gene	contributes|xcomp|START_ENTITY contributes|nsubj|END_ENTITY	Pannexin_1 contributes to ATP release in airway epithelia .
18842589	0	ATP	204,207	Pdr5	138,142	ATP	Pdr5	MESH:D000255	854324(Tax:4932)	Chemical	Gene	interface|nmod|START_ENTITY conservation|nmod|interface hydrolysis|nsubj|conservation define|parataxis|hydrolysis define|dobj|cross-talk cross-talk|nmod|domain domain|nmod|yeast yeast|acl|multidrug multidrug|dobj|END_ENTITY	Mutations define cross-talk between the N-terminal nucleotide-binding domain and transmembrane helix-2 of the yeast multidrug transporter Pdr5 : possible conservation of a signaling interface for coupling ATP hydrolysis to drug transport .
8810273	0	ATP	4,7	Pdr5	38,42	ATP	Pdr5	MESH:D000255	854324(Tax:4932)	Chemical	Gene	cassette|compound|START_ENTITY transporters|nsubj|cassette transporters|ccomp|mediate mediate|nsubj|END_ENTITY	The ATP binding cassette transporters Pdr5 and Snq2 of Saccharomyces_cerevisiae can mediate transport of steroids in vivo .
21747211	0	ATP	50,53	Per1	26,30	ATP	Per1	MESH:D000255	5187	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Selective upregulation of Per1 mRNA expression by ATP through activation of P2X7 purinergic receptors expressed in microglial cells .
12407192	0	ATP	92,95	PilT	19,23	ATP	PilT	MESH:D000255	10076095	Chemical	Gene	START_ENTITY|nsubj|protein protein|compound|END_ENTITY	The cyanobacterial PilT protein responsible for cell motility and transformation hydrolyzes ATP .
7840215	0	ATP	20,23	Protein_kinase_C	0,16	ATP	Protein kinase C	MESH:D000255	112476	Chemical	Gene	regulation|compound|START_ENTITY END_ENTITY|nmod|regulation	Protein_kinase_C in ATP regulation of lung surfactant secretion in type II cells .
11861548	2	ATP	248,251	Prp22	266,271	ATP	Prp22	MESH:D000255	856732(Tax:4932)	Chemical	Gene	hydrolysis|compound|START_ENTITY hydrolysis|nmod|END_ENTITY	ATP hydrolysis by Prp22 is necessary but not sufficient for spliceosome disassembly .
11923292	0	ATP	0,3	RAD51	28,33	ATP	RAD51	MESH:D000255	5888	Chemical	Gene	hydrolysis|compound|START_ENTITY hydrolysis|nmod|END_ENTITY	ATP hydrolysis by mammalian RAD51 has a key role during homology-directed DNA repair .
26609812	0	ATP	0,3	RIG-I	39,44	ATP	RIG-I	MESH:D000255	23586	Chemical	Gene	hydrolysis|compound|START_ENTITY hydrolysis|nmod|END_ENTITY	ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA .
26933836	0	ATP	12,15	RIG-I	51,56	ATP	RIG-I	MESH:D000255	23586	Chemical	Gene	hydrolysis|compound|START_ENTITY hydrolysis|nmod|END_ENTITY	Correction : ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA .
22253197	0	ATP	25,28	Rab25	0,5	ATP	Rab25	MESH:D000255	57111	Chemical	Gene	increases|dobj|START_ENTITY increases|nsubj|END_ENTITY	Rab25 increases cellular ATP and glycogen stores protecting cancer cells from bioenergetic stress .
25346869	0	ATP	6,9	Rad10	60,65	ATP	Rad10	MESH:D000255	854878(Tax:4932)	Chemical	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	Rad51 ATP binding but not hydrolysis is required to recruit Rad10 in synthesis-dependent strand annealing sites in S. _ cerevisiae .
12192033	0	ATP	20,23	Rad51	63,68	ATP	Rad51	MESH:D000255	856831(Tax:4932)	Chemical	Gene	hydrolysis|compound|START_ENTITY hydrolysis|nmod|END_ENTITY	The requirement for ATP hydrolysis by Saccharomyces_cerevisiae Rad51 is bypassed by mating-type heterozygosity or RAD54 in high copy .
1644828	0	ATP	15,18	RecA	33,37	ATP	RecA	MESH:D000255	5888	Chemical	Gene	hydrolysis|compound|START_ENTITY hydrolysis|nmod|END_ENTITY	On the role of ATP hydrolysis in RecA protein-mediated DNA strand exchange .
8051165	0	ATP	15,18	RecA	33,37	ATP	RecA	MESH:D000255	5888	Chemical	Gene	hydrolysis|compound|START_ENTITY hydrolysis|nmod|END_ENTITY	On the role of ATP hydrolysis in RecA protein-mediated DNA strand exchange .
8076649	0	ATP	95,98	RecA	71,75	ATP	RecA	MESH:D000255	5888	Chemical	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	Spectroscopic observation of renaturation between polynucleotides with RecA in the presence of ATP hydrolysis .
21069970	0	ATP	43,46	SAV1866	58,65	ATP	SAV1866	MESH:D000255	1213339(Tax:227882)	Chemical	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	Dynamics and structural changes induced by ATP binding in SAV1866 , a bacterial ABC exporter .
7629127	0	ATP	61,64	SNQ2	39,43	ATP	SNQ2	MESH:D000255	851574(Tax:4932)	Chemical	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification and characterization of SNQ2 , a new multidrug ATP binding cassette transporter of the yeast plasma membrane .
20599768	8	ATP	1318,1321	Src	1344,1347	ATP	Src	MESH:D000255	20779(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|direct direct|nmod|END_ENTITY	A pull-down assay revealed that kaempferol competes with ATP for direct binding to Src .
11157746	0	ATP	52,55	TAP	67,70	ATP	TAP	MESH:D000255	6890	Chemical	Gene	binding|nsubj|START_ENTITY binding|nmod|END_ENTITY	The human_cytomegalovirus gene product US6 inhibits ATP binding by TAP .
18303186	0	ATP	36,39	THP-1	43,48	ATP	THP-1	MESH:D000255	2736	Chemical	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	Role of TNF-alpha and extracellular ATP in THP-1 cell activation following allergen exposure .
18303186	0	ATP	36,39	TNF-alpha	8,17	ATP	TNF-alpha	MESH:D000255	7124	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of TNF-alpha and extracellular ATP in THP-1 cell activation following allergen exposure .
11691993	0	ATP	29,32	TOR	10,13	ATP	TOR	MESH:D000255	6097	Chemical	Gene	sensor|compound|START_ENTITY END_ENTITY|dep|sensor	Mammalian TOR : a homeostatic ATP sensor .
24247430	0	ATP	27,30	TOR	23,26	ATP	TOR	MESH:D000255	21977(Tax:10090)	Chemical	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	Phosphorylation of the TOR ATP binding domain by AGC kinase constitutes a novel mode of TOR inhibition .
22492652	0	ATP	64,67	TRPV4	0,5	ATP	TRPV4	MESH:D000255	59341	Chemical	Gene	release|compound|START_ENTITY regulates|dobj|release regulates|nsubj|END_ENTITY	TRPV4 in porcine lens epithelium regulates hemichannel-mediated ATP release and Na-K-ATPase activity .
19805577	0	ATP	0,3	TRPV6	29,34	ATP	TRPV6	MESH:D000255	55503	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	ATP modulates Ca2 + uptake by TRPV6 and is counteracted by isoform-specific phosphorylation .
3272345	2	ATP	95,98	TdT	124,127	ATP	TdT	MESH:D000255	294051(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of ATP on free and matrix bound TdT .
9374498	0	ATP	38,41	Tumor_necrosis_factor-alpha	0,27	ATP	Tumor necrosis factor-alpha	MESH:D000255	21926(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|increases increases|amod|END_ENTITY	Tumor_necrosis_factor-alpha increases ATP content in metabolically inhibited L929 cells preceding cell death .
15477379	0	ATP	58,61	Voltage-dependent_anion_channel-1	0,33	ATP	Voltage-dependent anion channel-1	MESH:D000255	22333(Tax:10090)	Chemical	Gene	contributes|xcomp|START_ENTITY contributes|nsubj|END_ENTITY	Voltage-dependent_anion_channel-1 -LRB- VDAC-1 -RRB- contributes to ATP release and cell volume regulation in murine cells .
8706137	0	ATP	0,3	XylR	48,52	ATP	XylR	MESH:D000255	1218757(Tax:303)	Chemical	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	ATP binding to the sigma 54-dependent activator XylR triggers a protein multimerization cycle catalyzed by UAS DNA .
9489676	4	ATP	898,901	XylR	998,1002	ATP	XylR	MESH:D000255	1218757(Tax:303)	Chemical	Gene	addition|nmod|START_ENTITY enhanced|nsubj|addition enhanced|nmod|END_ENTITY	The addition of ATP , known to trigger multimerization of the regulator at the UAS , enhanced the repression of Pr by XylR .
22761424	0	ATP	82,85	aryl_hydrocarbon_receptor	134,159	ATP	aryl hydrocarbon receptor	MESH:D000255	11622(Tax:10090)	Chemical	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Polycyclic_aromatic_hydrocarbons -LRB- PAHs -RRB- mediate transcriptional activation of the ATP binding cassette transporter ABCB6 gene via the aryl_hydrocarbon_receptor -LRB- AhR -RRB- .
22715356	0	ATP	0,3	brain-derived_neurotrophic_factor	12,45	ATP	brain-derived neurotrophic factor	MESH:D000255	627	Chemical	Gene	START_ENTITY|acl|induced induced|dobj|expression expression|amod|END_ENTITY	ATP induced brain-derived_neurotrophic_factor expression and release from osteoarthritis synovial fibroblasts is mediated by purinergic_receptor_P2X4 .
11038302	0	ATP	0,3	c-fos	12,17	ATP	c-fos	MESH:D000255	2353	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	ATP induces c-fos expression in C6 glioma cells by activation of P -LRB- 2Y -RRB- receptors .
15196691	0	ATP	0,3	caspase-9	45,54	ATP	caspase-9	MESH:D000255	842	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|activity activity|amod|END_ENTITY	ATP and cytochrome_c-dependent inhibition of caspase-9 activity in the cerebral cortex of newborn piglets .
15280366	0	ATP	79,82	caspase-9	91,100	ATP	caspase-9	MESH:D000255	842	Chemical	Gene	requires|dobj|START_ENTITY requires|nmod|END_ENTITY	Neuronal_apoptosis-inhibitory_protein does not interact with Smac and requires ATP to bind caspase-9 .
15755925	0	ATP	19,22	caspase-9	76,85	ATP	caspase-9	MESH:D000255	842	Chemical	Gene	depletion-induced|nsubj|START_ENTITY depletion-induced|advcl|blocking blocking|dobj|activation activation|amod|END_ENTITY	Acidic pH inhibits ATP depletion-induced tubular cell apoptosis by blocking caspase-9 activation in apoptosome .
17976908	0	ATP	0,3	caspase-9	45,54	ATP	caspase-9	MESH:D000255	842	Chemical	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	ATP and cytochrome_c-dependent activation of caspase-9 during hypoxia in the cerebral cortex of newborn piglets .
24548565	0	ATP	72,75	connexin	16,24	ATP	connexin	MESH:D000255	100128922	Chemical	Gene	release|compound|START_ENTITY Differentiating|nmod|release Differentiating|dobj|hemichannels hemichannels|compound|END_ENTITY	Differentiating connexin hemichannels and pannexin channels in cellular ATP release .
12139449	0	ATP	12,15	cyclin-dependent_kinases_1_and_2	41,73	ATP	cyclin-dependent kinases 1 and 2	MESH:D000255	983;1017	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Probing the ATP ribose-binding domain of cyclin-dependent_kinases_1_and_2 with O -LRB- 6 -RRB- - substituted_guanine derivatives .
11443051	0	ATP	101,104	cyclooxygenase-2	26,42	ATP	cyclooxygenase-2	MESH:D000255	442942(Tax:9615)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Key role for constitutive cyclooxygenase-2 of MDCK cells in basal signaling and response to released ATP .
16966475	0	ATP	8,11	cystic_fibrosis_transmembrane_conductance_regulator	29,80	ATP	cystic fibrosis transmembrane conductance regulator	MESH:D000255	1080	Chemical	Gene	sites|amod|START_ENTITY sites|nmod|END_ENTITY	The two ATP binding sites of cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- play distinct roles in gating kinetics and energetics .
8779917	0	ATP	9,12	cystic_fibrosis_transmembrane_conductance_regulator	28,79	ATP	cystic fibrosis transmembrane conductance regulator	MESH:D000255	1080	Chemical	Gene	release|nsubj|START_ENTITY release|nmod|END_ENTITY	Cellular ATP release by the cystic_fibrosis_transmembrane_conductance_regulator .
5016551	0	ATP	14,17	cytochrome_b	58,70	ATP	cytochrome b	MESH:D000255	4519	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of ATP on the apparent mid-point potentials of cytochrome_b and cytochrome_c in beef-heart mitochondria .
5117562	0	ATP	0,3	cytochrome_b	39,51	ATP	cytochrome b	MESH:D000255	26192(Tax:10116)	Chemical	Gene	induced|nsubj|START_ENTITY induced|dobj|changes changes|nmod|END_ENTITY	ATP and pH induced spectral changes of cytochrome_b in rat liver mitochondria .
11279142	0	ATP	0,3	cytochrome_c	51,63	ATP	cytochrome c	MESH:D000255	54205	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|change change|nmod|END_ENTITY	ATP induces a conformational change in lipid-bound cytochrome_c .
12881229	0	ATP	148,151	cytochrome_c	100,112	ATP	cytochrome c	MESH:D000255	54205	Chemical	Gene	levels|nmod|START_ENTITY levels|amod|END_ENTITY	Precursor peptide progastrin -LRB- 1-80 -RRB- reduces apoptosis of intestinal epithelial cells and upregulates cytochrome_c oxidase Vb levels and synthesis of ATP .
19231839	0	ATP	0,3	cytochrome_c	74,86	ATP	cytochrome c	MESH:D000255	54205	Chemical	Gene	acts|nsubj|START_ENTITY acts|nmod|effector effector|acl|modulating modulating|dobj|transitions transitions|nmod|END_ENTITY	ATP acts as a regulatory effector in modulating structural transitions of cytochrome_c : implications for apoptotic activity .
23331169	0	ATP	24,27	cytochrome_c	49,61	ATP	cytochrome c	MESH:D000255	54205	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Multifaceted effects of ATP on cardiolipin-bound cytochrome_c .
3032951	0	ATP	0,3	cytochrome_c	52,64	ATP	cytochrome c	MESH:D000255	104968582	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|changes changes|nmod|oxidase oxidase|amod|END_ENTITY	ATP induces conformational changes in mitochondrial cytochrome_c oxidase .
8386037	0	ATP	1,4	cytochrome_c	38,50	ATP	cytochrome c	MESH:D000255	54205	Chemical	Gene	formation|nsubj|START_ENTITY formation|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- ATP formation in a model system with cytochrome_c oxidase -RSB- .
21641552	0	ATP	75,78	cytochrome_oxidase	42,60	ATP	cytochrome oxidase	MESH:D000255	1351	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Protein phosphorylation and prevention of cytochrome_oxidase inhibition by ATP : coupled mechanisms of energy metabolism regulation .
1191313	0	ATP	10,13	dopamine-beta-hydroxylase	19,44	ATP	dopamine-beta-hydroxylase	MESH:D000255	1621	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of ATP upon dopamine-beta-hydroxylase .
8713682	0	ATP	87,90	epidermal_growth_factor_receptor	111,143	ATP	epidermal growth factor receptor	MESH:D000255	1956	Chemical	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Structure-activity relationships for 4-anilinoquinazolines as potent inhibitors at the ATP binding site of the epidermal_growth_factor_receptor in vitro .
2111815	0	ATP	11,14	eukaryotic_initiation_factor_2	18,48	ATP	eukaryotic initiation factor 2	MESH:D000255	8894	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of ATP to eukaryotic_initiation_factor_2 .
23192020	0	ATP	69,72	extracellular_signal-regulated_kinase_2	13,52	ATP	extracellular signal-regulated kinase 2	MESH:D000255	5594	Chemical	Gene	Structure|nmod|START_ENTITY Structure|nmod|END_ENTITY	Structure of extracellular_signal-regulated_kinase_2 in complex with ATP and ADP .
8092274	0	ATP	11,14	fibrinogen	49,59	ATP	fibrinogen	MESH:D000255	2244	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|receptor receptor|compound|END_ENTITY	Effects of ATP on ligand recognition of platelet fibrinogen receptor on GPIIb-IIIa .
21187124	0	ATP	0,3	fibroblast_growth_factor_2	31,57	ATP	fibroblast growth factor 2	MESH:D000255	14173(Tax:10090)	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	ATP differentially upregulates fibroblast_growth_factor_2 and transforming_growth_factor_a in neonatal and adult mice : effect on neuroproliferation .
11170435	0	ATP	70,73	glucocorticoid_receptor	115,138	ATP	glucocorticoid receptor	MESH:D000255	2908	Chemical	Gene	Evidence|nmod|START_ENTITY Evidence|nmod|END_ENTITY	Evidence for iterative ratcheting of receptor-bound hsp70 between its ATP and ADP conformations during assembly of glucocorticoid_receptor .
2291828	0	ATP	11,14	glucose-6-phosphate_dehydrogenase	18,51	ATP	glucose-6-phosphate dehydrogenase	MESH:D000255	100328765(Tax:9986)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Effect of ATP on glucose-6-phosphate_dehydrogenase during erythroblast maturation in the rabbit -RSB- .
8799466	0	ATP	15,18	glucose-6-phosphate_dehydrogenase	37,70	ATP	glucose-6-phosphate dehydrogenase	MESH:D000255	100328765(Tax:9986)	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of ATP with erythroblast glucose-6-phosphate_dehydrogenase .
6726228	0	ATP	11,14	glutamate_decarboxylase	24,47	ATP	glutamate decarboxylase	MESH:D000255	2752	Chemical	Gene	Binding|nmod|START_ENTITY END_ENTITY|nsubj|Binding	Binding of ATP to brain glutamate_decarboxylase as studied by affinity chromatography .
26277554	0	ATP	14,17	glyceraldehyde-3-phosphate_dehydrogenase	52,92	ATP	glyceraldehyde-3-phosphate dehydrogenase	MESH:D000255	2597	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|release release|nmod|END_ENTITY	Extracellular ATP induces unconventional release of glyceraldehyde-3-phosphate_dehydrogenase from microglial cells .
10819984	0	ATP	75,78	helicase	48,56	ATP	helicase	MESH:D000255	164045	Chemical	Gene	absence|nmod|START_ENTITY END_ENTITY|nmod|absence	Strand-separating activity of hepatitis_C_virus helicase in the absence of ATP .
11304544	0	ATP	68,71	helicase	130,138	ATP	helicase	MESH:D000255	164045	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|domain domain|compound|END_ENTITY	Characterization of recombinant HPV6 and 11 E1 helicases : effect of ATP on the interaction of E1 with E2 and mapping of a minimal helicase domain .
16893956	0	ATP	8,11	helicase	95,103	ATP	helicase	MESH:D000255	164045	Chemical	Gene	Role|nmod|START_ENTITY hydrolysis|nsubj|Role hydrolysis|nmod|activity activity|nmod|END_ENTITY	Role of ATP hydrolysis in the DNA translocase activity of the bovine papillomavirus -LRB- BPV-1 -RRB- E1 helicase .
19153239	0	ATP	59,62	helicase	85,93	ATP	helicase	MESH:D000255	164045	Chemical	Gene	hydrolysis|compound|START_ENTITY promotes|dobj|hydrolysis promotes|nmod|END_ENTITY	The NS4A protein_of_hepatitis_C_virus promotes RNA-coupled ATP hydrolysis by the NS3 helicase .
19839642	0	ATP	66,69	helicase	13,21	ATP	helicase	MESH:D000255	164045	Chemical	Gene	hydrolysis|compound|START_ENTITY maintains|nmod|hydrolysis END_ENTITY|ccomp|maintains	The DEAD box helicase YxiN maintains a closed conformation during ATP hydrolysis .
20978807	0	ATP	51,54	helicase	81,89	ATP	helicase	MESH:D000255	164045	Chemical	Gene	hydrolysis|compound|START_ENTITY regulates|dobj|hydrolysis regulates|nmod|END_ENTITY	The acidic sequence of the NS4A cofactor regulates ATP hydrolysis by the HCV NS3 helicase .
23948158	0	ATP	22,25	helicase	99,107	ATP	helicase	MESH:D000255	164045	Chemical	Gene	hydrolysis|compound|START_ENTITY detecting|dobj|hydrolysis Methods|acl|detecting END_ENTITY|nsubj|Methods	Methods for detecting ATP hydrolysis and nucleic acid unwinding of Japanese_encephalitis_virus NS3 helicase .
6251042	1	ATP	44,47	helicase	51,59	ATP	helicase	MESH:D000255	164045	Chemical	Gene	role|nmod|START_ENTITY role|nmod|activity activity|amod|END_ENTITY	The role of ATP in helicase III activity .
10574795	0	ATP	25,28	hexokinase	38,48	ATP	hexokinase	MESH:D000255	851167(Tax:4932)	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of non-catalytic ATP to human hexokinase I highlights the structural components for enzyme-membrane association control .
19285951	0	ATP	88,91	histidine-rich_glycoprotein	34,61	ATP	histidine-rich glycoprotein	MESH:D000255	3273	Chemical	Gene	START_ENTITY|nsubj|interaction interaction|nmod|END_ENTITY	High affinity interaction between histidine-rich_glycoprotein and the cell surface type ATP synthase on T-cells .
2143485	0	ATP	71,74	hsp60	106,111	ATP	hsp60	MESH:D000255	850963(Tax:4932)	Chemical	Gene	synthase|compound|START_ENTITY synthase|nmod|END_ENTITY	Identification of a 66 KDa protein associated with yeast mitochondrial ATP synthase as heat_shock protein hsp60 .
11170435	0	ATP	70,73	hsp70	52,57	ATP	hsp70	MESH:D000255	3308	Chemical	Gene	Evidence|nmod|START_ENTITY Evidence|nmod|END_ENTITY	Evidence for iterative ratcheting of receptor-bound hsp70 between its ATP and ADP conformations during assembly of glucocorticoid_receptor .
10364185	0	ATP	18,21	hsp90	48,53	ATP	hsp90	MESH:D000255	3320	Chemical	Gene	importance|nmod|START_ENTITY binding|nsubj|importance binding|nmod|END_ENTITY	The importance of ATP binding and hydrolysis by hsp90 in formation and function of protein heterocomplexes .
12324468	0	ATP	17,20	hsp90	52,57	ATP	hsp90	MESH:D000255	3320	Chemical	Gene	influence|nmod|START_ENTITY influence|nmod|conformation conformation|nmod|END_ENTITY	The influence of ATP and p23 on the conformation of hsp90 .
12667448	0	ATP	84,87	hsp90	60,65	ATP	hsp90	MESH:D000255	855836(Tax:4932)	Chemical	Gene	hydrolysis|compound|START_ENTITY implications|nmod|hydrolysis analysis|dep|implications analysis|nmod|segment segment|nmod|END_ENTITY	Structural and functional analysis of the middle segment of hsp90 : implications for ATP hydrolysis and client protein and cochaperone interactions .
7779083	0	ATP	0,3	hsp90	59,64	ATP	hsp90	MESH:D000255	3320	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|dissociation dissociation|nmod|protein protein|appos|END_ENTITY	ATP induces dissociation of the 90 kDa heat_shock protein -LRB- hsp90 -RRB- from F-actin : interference with the binding of heavy meromyosin .
8420964	0	ATP	0,3	hsp90	70,75	ATP	hsp90	MESH:D000255	299331(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|change change|nmod|END_ENTITY	ATP induces a conformational change of the 90-kDa_heat_shock_protein -LRB- hsp90 -RRB- .
9691273	0	ATP	0,3	hsp90	29,34	ATP	hsp90	MESH:D000255	3320	Chemical	Gene	START_ENTITY|dep|tryptophans tryptophans|nmod|END_ENTITY	ATP sensitive tryptophans of hsp90 .
8262154	0	ATP	10,13	hsp_70	32,38	ATP	hsp 70	MESH:D000255	3308	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|release release|nmod|END_ENTITY	Effect of ATP on the release of hsp_70 and hsp_40 from the nucleus in heat-shocked HeLa cells .
1656236	7	ATP	1393,1396	human	1387,1392	ATP	Ets-1	MESH:D000255	2113	Chemical	Gene	subunit|compound|START_ENTITY subunit|amod|END_ENTITY	In addition , a single polypeptide of 55 kDa was detected following cross-linking of a partially purified NRF-2 fraction to RCO4 , the human ATP synthase beta subunit , or Moloney_murine_sarcoma_virus binding sites .
18400751	6	ATP	813,816	human	831,836	ATP	Hsp90	MESH:D000255	855836(Tax:4932)	Chemical	Gene	hydrolysis|compound|START_ENTITY hydrolysis|nmod|Hsp90alpha Hsp90alpha|amod|END_ENTITY	ATP hydrolysis by human Hsp90alpha and Hsp90beta is 10-fold slower than that of yeast Hsp90 .
22137029	4	ATP	883,886	hydrogen_peroxide	797,814	ATP	HMG CoA reductase	MESH:D000255	3156	Chemical	Gene	synthase|amod|START_ENTITY synthase|dep|END_ENTITY	Cholesterol substrate was added to the plasma of the patients and the generation of cytochrome F420 , free RNA , free DNA , polycyclic_aromatic_hydrocarbon , hydrogen_peroxide , serotonin , pyruvate , ammonia , glutamate , cytochrome_C , hexokinase , ATP synthase , HMG_CoA reductase , digoxin and bile_acids were studied .
9555100	8	ATP	1342,1345	iPLA2	1305,1310	ATP	cPLA2	MESH:D000255	24653(Tax:10116)	Chemical	Gene	stimulated|nmod|START_ENTITY stimulated|nsubjpass|END_ENTITY	Comparison of recombinant islet cPLA2 and iPLA2 activities expressed in transfected COS-7 cells indicated that iPLA2 but not cPLA2 is stimulated by ATP .
10630382	0	ATP	16,19	insulin	76,83	ATP	insulin	MESH:D000255	3630	Chemical	Gene	Metabolic|appos|START_ENTITY Metabolic|dep|actions actions|nmod|initiators initiators|nmod|secretion secretion|compound|END_ENTITY	Metabolic and K -LRB- ATP -RRB- channel-independent actions of keto_acid initiators of insulin secretion .
10896818	0	ATP	93,96	insulin	11,18	ATP	insulin	MESH:D000255	3630	Chemical	Gene	increases|dobj|START_ENTITY increases|nsubj|use use|nmod|END_ENTITY	The use of insulin and glucose during resuscitation from hemorrhagic_shock increases hepatic ATP .
11868613	0	ATP	46,49	insulin	85,92	ATP	insulin	MESH:D000255	3630	Chemical	Gene	potassium|appos|START_ENTITY coupled|nsubjpass|potassium coupled|nmod|resistance resistance|compound|END_ENTITY	Adenosine_triphosphate-sensitive potassium -LRB- K -LRB- ATP -RRB- -RRB- channel activity is coupled with insulin resistance in obesity and type_2_diabetes_mellitus .
12808136	0	ATP	57,60	insulin	10,17	ATP	insulin	MESH:D000255	3630	Chemical	Gene	production|compound|START_ENTITY mitochondrial|dobj|production mitochondrial|nsubj|Effect Effect|nmod|END_ENTITY	Effect of insulin on human skeletal muscle mitochondrial ATP production , protein synthesis , and mRNA transcripts .
14764798	0	ATP	57,60	insulin	97,104	ATP	insulin	MESH:D000255	3630	Chemical	Gene	K|appos|START_ENTITY K|parataxis|preserves preserves|dobj|stores stores|compound|END_ENTITY	Induction of beta-cell rest by a Kir6 .2 / SUR1-selective K -LRB- ATP -RRB- - channel opener preserves beta-cell insulin stores and insulin secretion in human islets cultured at high -LRB- 11 mM -RRB- glucose .
17660267	0	ATP	54,57	insulin	10,17	ATP	insulin	MESH:D000255	3630	Chemical	Gene	production|compound|START_ENTITY mitochondrial|dobj|production mitochondrial|nsubj|Effect Effect|nmod|deprivation deprivation|compound|END_ENTITY	Effect of insulin deprivation on muscle mitochondrial ATP production and gene transcript levels in type 1 diabetic subjects .
18815553	0	ATP	15,18	insulin	38,45	ATP	insulin	MESH:D000255	3630	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|compound|END_ENTITY	Dual effect of ATP on glucose-induced insulin secretion in HIT-T15 cells .
19011133	0	ATP	87,90	insulin	16,23	ATP	insulin	MESH:D000255	3630	Chemical	Gene	effect|appos|START_ENTITY mediator|nmod|effect Rab27A|dobj|mediator secretion|dep|Rab27A secretion|compound|END_ENTITY	Glucose-induced insulin secretion : is the small G-protein Rab27A the mediator of the K -LRB- ATP -RRB- channel-independent effect ?
20623795	0	ATP	50,53	insulin	30,37	ATP	insulin	MESH:D000255	3630	Chemical	Gene	rate|compound|START_ENTITY Measuring|nmod|rate Measuring|dobj|effect effect|nmod|infusion infusion|compound|END_ENTITY	Measuring the acute effect of insulin infusion on ATP turnover rate in human skeletal muscle using phosphorus-31 magnetic resonance saturation transfer spectroscopy .
21602835	0	ATP	27,30	insulin	71,78	ATP	insulin	MESH:D000255	3630	Chemical	Gene	channels|compound|START_ENTITY understanding|nmod|channels understanding|dep|focus focus|nmod|disorders disorders|compound|END_ENTITY	Current understanding of K ATP channels in neonatal_diseases : focus on insulin secretion disorders .
22555472	0	ATP	63,66	insulin	19,26	ATP	insulin	MESH:D000255	3630	Chemical	Gene	targets|nmod|START_ENTITY signalling|dep|targets signalling|nmod|secretion secretion|compound|END_ENTITY	Cell signalling in insulin secretion : the molecular targets of ATP , cAMP and sulfonylurea .
3907636	0	ATP	21,24	insulin	43,50	ATP	insulin	MESH:D000255	3630	Chemical	Gene	turnover|compound|START_ENTITY stimulation|nmod|turnover stimulation|nmod|END_ENTITY	Early stimulation of ATP turnover by EGF + insulin .
5967016	0	ATP	15,18	insulin	76,83	ATP	insulin	MESH:D000255	280829(Tax:9913)	Chemical	Gene	content|compound|START_ENTITY Changes|nmod|content thymus|nsubj|Changes thymus|nmod|influence influence|nmod|END_ENTITY	Changes in the ATP content of the calf thymus nuclei under the influence of insulin .
8511877	0	ATP	37,40	insulin	86,93	ATP	insulin	MESH:D000255	3630	Chemical	Gene	Synthesis|nmod|START_ENTITY stimulated|nsubj|Synthesis stimulated|nmod|END_ENTITY	-LSB- Synthesis of cell membrane `` signal '' ATP in human erythrocyte membranes stimulated by insulin as criteria of the efficacy of therapeutic plasmapheresis -RSB- .
11368426	0	ATP	0,3	insulin-degrading_enzyme	13,37	ATP	insulin-degrading enzyme	MESH:D000255	25700(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	ATP inhibits insulin-degrading_enzyme activity .
15494400	0	ATP	0,3	insulin-degrading_enzyme	15,39	ATP	insulin-degrading enzyme	MESH:D000255	3416	Chemical	Gene	effects|compound|START_ENTITY effects|nmod|END_ENTITY	ATP effects on insulin-degrading_enzyme are mediated primarily through its triphosphate moiety .
24697863	0	ATP	60,63	insulin_degrading_enzyme	78,102	ATP	insulin degrading enzyme	MESH:D000255	3416	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	Molecular dynamics simulations reveal a novel mechanism for ATP inhibition of insulin_degrading_enzyme .
16716291	0	ATP	0,3	interleukin-6	15,28	ATP	interleukin-6	MESH:D000255	3569	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|amod|END_ENTITY	ATP stimulates interleukin-6 production via P2Y receptors in human HaCaT keratinocytes .
10556073	0	ATP	25,28	left-right_dynein	47,64	ATP	left-right dynein	MESH:D000255	13411(Tax:10090)	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Targeted deletion of the ATP binding domain of left-right_dynein confirms its role in specifying development of left-right asymmetries .
12161019	0	ATP	0,3	leukemia_inhibitory_factor	12,38	ATP	leukemia inhibitory factor	MESH:D000255	60584(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|mRNA mRNA|compound|END_ENTITY	ATP induces leukemia_inhibitory_factor mRNA in cultured rat astrocytes .
2029629	0	ATP	34,37	luteinizing_hormone-releasing_hormone	115,152	ATP	luteinizing hormone-releasing hormone	MESH:D000255	25194(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY role|dep|facilitation facilitation|nmod|stimulation stimulation|nmod|release release|nmod|END_ENTITY	A putative role for extracellular ATP : facilitation of 67copper uptake and of copper stimulation of the release of luteinizing_hormone-releasing_hormone from median eminence explants .
7050305	0	ATP	29,32	luteinizing_hormone-releasing_hormone	68,105	ATP	luteinizing hormone-releasing hormone	MESH:D000255	2796	Chemical	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|END_ENTITY	Comparison of the effects of ATP , Mg2 + , and MgATP on the release of luteinizing_hormone-releasing_hormone from isolated hypothalamic granules .
20223663	0	ATP	99,102	mTOR	115,119	ATP	mTOR	MESH:D000255	21977(Tax:10090)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	2-Arylureidophenyl-4 - -LRB- 3-oxa-8-azabicyclo -LSB- 3.2.1 -RSB- octan-8-yl -RRB- triazines as highly potent and selective ATP competitive mTOR inhibitors : optimization of human microsomal stability .
21591993	0	ATP	51,54	mTOR	67,71	ATP	mTOR	MESH:D000255	21977(Tax:10090)	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Recent advances in the discovery of small-molecule ATP competitive mTOR inhibitors : a patent review .
15167983	0	ATP	0,3	macrophage-derived_chemokine	15,43	ATP	macrophage-derived chemokine	MESH:D000255	6367	Chemical	Gene	START_ENTITY|nmod|responses responses|amod|END_ENTITY	ATP priming of macrophage-derived_chemokine responses in CHO cells expressing the CCR4 receptor .
2165421	0	ATP	93,96	mitochondrial_ATPase	72,92	ATP	mitochondrial ATPase	MESH:D000255	514	Chemical	Gene	synthase|compound|START_ENTITY induced|nsubj|synthase increase|parataxis|induced increase|nmod|END_ENTITY	Flux-dependent increase in the stoichiometry of charge translocation by mitochondrial_ATPase / ATP synthase induced by almitrine .
2896192	0	ATP	37,40	mitochondrial_ATPase	91,111	ATP	mitochondrial ATPase	MESH:D000255	514	Chemical	Gene	hydrolysis|nmod|START_ENTITY Rate|nmod|hydrolysis END_ENTITY|nsubj|Rate	Rate of chase-promoted hydrolysis of ATP in the high affinity catalytic site of beef heart mitochondrial_ATPase .
6227615	0	ATP	46,49	mitochondrial_ATPase	53,73	ATP	mitochondrial ATPase	MESH:D000255	514	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of the synthesis and hydrolysis of ATP by mitochondrial_ATPase .
7600576	0	ATP	121,124	mt-Hsp70	112,120	ATP	mt-Hsp70	MESH:D000255	3313	Chemical	Gene	system|compound|START_ENTITY system|amod|END_ENTITY	The MIM complex mediates preprotein translocation across the mitochondrial inner membrane and couples it to the mt-Hsp70 / ATP driving system .
11336637	0	ATP	110,113	multidrug_resistance_protein	46,74	ATP	multidrug resistance protein	MESH:D000255	5243	Chemical	Gene	control|nmod|START_ENTITY END_ENTITY|nmod|control	Role of glycine-534 and glycine-1179 of human multidrug_resistance_protein -LRB- MDR1 -RRB- in drug-mediated control of ATP hydrolysis .
15269137	0	ATP	59,62	multidrug_resistance_protein_1	28,58	ATP	multidrug resistance protein 1	MESH:D000255	4363	Chemical	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Alternative splicing of the multidrug_resistance_protein_1 / ATP binding cassette transporter subfamily gene in ovarian_cancer creates functional splice variants and is associated with increased expression of the splicing factors PTB and SRp20 .
16697012	0	ATP	96,99	multidrug_resistance_protein_1	23,53	ATP	multidrug resistance protein 1	MESH:D000255	4363	Chemical	Gene	reveals|nsubj|START_ENTITY Structure|parataxis|reveals Structure|nmod|domain domain|amod|END_ENTITY	Structure of the human multidrug_resistance_protein_1 nucleotide binding domain 1 bound to Mg2 + / ATP reveals a non-productive catalytic site .
1826852	0	ATP	99,102	myosin	112,118	ATP	myosin	MESH:D000255	79784	Chemical	Gene	sites|compound|START_ENTITY sites|nmod|END_ENTITY	Cryoenzymic studies on actomyosin ATPase : kinetic evidence for communication between the actin and ATP sites on myosin .
20923650	0	ATP	66,69	myosin	86,92	ATP	myosin	MESH:D000255	79784	Chemical	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Fluorescence lifetime imaging reveals that the environment of the ATP binding site of myosin in muscle senses force .
2932162	0	ATP	132,135	myosin	64,70	ATP	myosin	MESH:D000255	79784	Chemical	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	Influence of the regulatory light chain of fast skeletal muscle myosin on its interaction with actin in the presence and absence of ATP .
7292626	0	ATP	75,78	myosin	10,16	ATP	myosin	MESH:D000255	79784	Chemical	Gene	-RSB-|compound|START_ENTITY changes|nmod|-RSB- changes|nsubj|END_ENTITY	-LSB- Muscular myosin structural and functional changes during interaction with ATP and bivalent ions -RSB- .
8419940	0	ATP	73,76	myosin	101,107	ATP	myosin	MESH:D000255	79784	Chemical	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Photolabeling evidence for calcium-induced conformational changes at the ATP binding site of scallop myosin .
14644769	0	ATP	88,91	myosin_light_chain_kinase	56,81	ATP	myosin light chain kinase	MESH:D000255	488012(Tax:9615)	Chemical	Gene	depletion|compound|START_ENTITY END_ENTITY|nmod|depletion	Regulation of MDCK cell-substratum adhesion by RhoA and myosin_light_chain_kinase after ATP depletion .
19897001	0	ATP	11,14	nerve_growth_factor	18,37	ATP	nerve growth factor	MESH:D000255	310738(Tax:10116)	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of ATP to nerve_growth_factor : characterization and relevance for bioactivity .
9442472	0	ATP	11,14	nitric_oxide_synthase	73,94	ATP	nitric oxide synthase	MESH:D000255	4843	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|compound|END_ENTITY	Effects of ATP , ADP , thrombin , vasopressin and U46619 on human placental nitric_oxide_synthase activity .
21444723	0	ATP	49,52	p38	71,74	ATP	p38	MESH:D000255	1432	Chemical	Gene	pocket|compound|START_ENTITY pocket|nmod|END_ENTITY	Acetylation of a conserved lysine residue in the ATP binding pocket of p38 augments its kinase activity during hypertrophy of cardiomyocytes .
2196558	0	ATP	54,57	phosphoglycerate_kinase	80,103	ATP	phosphoglycerate kinase	MESH:D000255	850370(Tax:4932)	Chemical	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Site-directed mutagenesis of aspartic_acid 372 at the ATP binding site of yeast phosphoglycerate_kinase : over-expression and characterization of the mutant enzyme .
165493	0	ATP	11,14	progesterone_receptor	22,43	ATP	progesterone receptor	MESH:D000255	5241	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of ATP to the progesterone_receptor .
7713939	0	ATP	57,60	protein_kinase_C-delta	22,44	ATP	protein kinase C-delta	MESH:D000255	5580	Chemical	Gene	START_ENTITY|nsubj|Characterization Characterization|nmod|END_ENTITY	Characterization of a protein_kinase_C-delta -LRB- PKC-delta -RRB- ATP binding mutant .
15546877	0	ATP	48,51	rad50	42,47	ATP	rad50	MESH:D000255	855471(Tax:4932)	Chemical	Gene	domain|compound|START_ENTITY domain|amod|END_ENTITY	Effect of amino_acid substitutions in the rad50 ATP binding domain on DNA double strand break repair in yeast .
23992455	0	ATP	0,3	serine_racemase	21,36	ATP	serine racemase	MESH:D000255	63826	Chemical	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	ATP binding to human serine_racemase is cooperative and modulated by glycine .
7755553	0	ATP	91,94	skeletal_muscle_ryanodine_receptor	41,75	ATP	skeletal muscle ryanodine receptor	MESH:D000255	6261	Chemical	Gene	analogue|compound|START_ENTITY END_ENTITY|nmod|analogue	Activation and labelling of the purified skeletal_muscle_ryanodine_receptor by an oxidized ATP analogue .
10936177	0	ATP	14,17	tumor_necrosis_factor-alpha	27,54	ATP	tumor necrosis factor-alpha	MESH:D000255	24835(Tax:10116)	Chemical	Gene	triggers|nsubj|START_ENTITY triggers|dobj|release release|amod|END_ENTITY	Extracellular ATP triggers tumor_necrosis_factor-alpha release from rat microglia .
2844229	0	ATP	123,126	type_I_DNA_topoisomerase	41,65	ATP	type I DNA topoisomerase	MESH:D000255	7150	Chemical	Gene	insensitive|nmod|START_ENTITY insensitive|nsubj|Mechanism Mechanism|nmod|inhibition inhibition|nmod|END_ENTITY	Mechanism of ATP inhibition of mammalian type_I_DNA_topoisomerase : DNA binding , cleavage , and rejoining are insensitive to ATP .
2844229	0	ATP	13,16	type_I_DNA_topoisomerase	41,65	ATP	type I DNA topoisomerase	MESH:D000255	7150	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	Mechanism of ATP inhibition of mammalian type_I_DNA_topoisomerase : DNA binding , cleavage , and rejoining are insensitive to ATP .
19625689	0	ATP	61,64	vasopressin	25,36	ATP	vasopressin	MESH:D000255	551	Chemical	Gene	release|nmod|START_ENTITY release|compound|END_ENTITY	Sustained stimulation of vasopressin and oxytocin release by ATP and phenylephrine requires recruitment of desensitization-resistant P2X purinergic receptors .
15111016	0	ATPA	60,64	GluR5	68,73	ATPA	GluR5	null	14805(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Topiramate selectively protects against seizures induced by ATPA , a GluR5 kainate receptor agonist .
20030938	0	ATRA	11,15	Hoxb2	43,48	ATRA	Hoxb2	null	3212	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of ATRA on the expression of genes Hoxb2 and Hoxb4 in cord blood erythroid progenitors -RSB- .
24314292	0	ATRA	40,44	IL-5	86,90	ATRA	IL-5	null	3567	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	The retinoic_acid receptor-a modulators ATRA and Ro415253 reciprocally regulate human IL-5 + Th2 cell proliferation and cytokine expression .
15182588	0	ATRA	11,15	VEGF	59,63	ATRA	VEGF	null	7422	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of ATRA and DNR on the expression and secretion of VEGF in leukemic cells -RSB- .
16530516	13	ATRA	1640,1644	XAF1	1648,1652	ATRA	XAF1	null	327959(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Furthermore , the effect of ATRA on XAF1 expression is independent of the promoter methylation and the subcellular distribution of XIAP .
19903244	0	ATRA	0,4	ceramide_kinase	14,29	ATRA	ceramide kinase	null	64781	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|transcription transcription|amod|END_ENTITY	ATRA inhibits ceramide_kinase transcription in a human neuroblastoma cell line , SH-SY5Y cells : the role of COUP-TFI .
27013100	0	ATRA	0,4	nSMase2	31,38	ATRA	nSMase2	null	55512	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	ATRA transcriptionally induces nSMase2 through CBP/p300-mediated Histone acetylation .
24421748	6	ATZ	1000,1003	catalase	1005,1013	ATZ	catalase	CHEBI:37924	24248(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Cardiovascular responses were evaluated before and 15 minutes after 3-amino-1 , _ 2 , _ 4-triazole -LRB- ATZ , catalase inhibitor , 0.001 g/100 L -RRB- injection into the 4 -LRB- th -RRB- V. RESULTS : Vehicle treatment into the 4 -LRB- th -RRB- V did not change cardiovascular responses .
18508449	0	AUDA	37,41	Soluble_epoxide_hydrolase	0,25	AUDA	Soluble epoxide hydrolase	null	65030(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Soluble_epoxide_hydrolase inhibitor , AUDA , prevents early salt-sensitive hypertension .
25975094	0	AUDA	69,73	soluble_epoxide_hydrolase	27,52	AUDA	soluble epoxide hydrolase	null	13850(Tax:10090)	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|effects effects|nmod|END_ENTITY	Therapeutic effects of the soluble_epoxide_hydrolase -LRB- sEH -RRB- inhibitor AUDA on atherosclerotic_diseases .
24100469	0	AUY922	56,62	HSP90	39,44	AUY922	HSP90	null	3320	Chemical	Gene	inhibitors|dobj|START_ENTITY inhibitors|nsubj|activity activity|nmod|END_ENTITY	Potent antitumor activity of the novel HSP90 inhibitors AUY922 and HSP990 in neuroendocrine carcinoid cells .
26445473	0	AUY922	21,27	Hsp90	37,42	AUY922	Hsp90	null	299331(Tax:10116)	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|compound|END_ENTITY	Preclinical Study of AUY922 , a Novel Hsp90 Inhibitor , in the Treatment of Esophageal_Adenocarcinoma .
19503102	0	AVE8134	75,82	PPAR-alpha	54,64	AVE8134	PPAR-alpha	MESH:C545089	25747(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY agonist|appos|END_ENTITY	The peroxisome_proliferator-activated_receptor-alpha -LRB- PPAR-alpha -RRB- agonist , AVE8134 , attenuates the progression of heart_failure and increases survival in rats .
22212431	0	AVE8134	0,7	PPARa	24,29	AVE8134	PPARa	MESH:C545089	19013(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	AVE8134 , a novel potent PPARa agonist , improves lipid profile and glucose metabolism in dyslipidemic mice and type 2 diabetic rats .
19503102	0	AVE8134	75,82	peroxisome_proliferator-activated_receptor-alpha	4,52	AVE8134	peroxisome proliferator-activated receptor-alpha	MESH:C545089	25747(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	The peroxisome_proliferator-activated_receptor-alpha -LRB- PPAR-alpha -RRB- agonist , AVE8134 , attenuates the progression of heart_failure and increases survival in rats .
19713152	0	AVI-4658	72,80	dystrophin	21,31	AVI-4658	dystrophin	MESH:C545511	1756	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Local restoration of dystrophin expression with the morpholino oligomer AVI-4658 in Duchenne_muscular_dystrophy : a single-blind , placebo-controlled , dose-escalation , proof-of-concept study .
1835898	0	AVP	52,55	ANP	8,11	AVP	ANP	CHEBI:34543	24602(Tax:10116)	Chemical	Gene	attenuates|nmod|START_ENTITY attenuates|nsubj|END_ENTITY	Central ANP attenuates pressor responses to central AVP in WKY and SHR .
1462855	0	AVP	113,116	Kallikrein	0,10	AVP	Kallikrein	CHEBI:34543	9622	Chemical	Gene	effects|nmod|START_ENTITY release|dep|effects release|compound|END_ENTITY	Kallikrein and kinin release using superfused disaggregated cortical cells from rat and human kidney : effects of AVP and dopamine .
20371731	0	AVP	38,41	angiotensin_I	8,21	AVP	angiotensin I	CHEBI:34543	183	Chemical	Gene	activity|compound|START_ENTITY increases|dobj|activity increases|nsubj|END_ENTITY	Central angiotensin_I increases fetal AVP neuron activity and pressor responses .
12040025	0	AVP	0,3	myocyte_enhancer_factor_2	69,94	AVP	myocyte enhancer factor 2	CHEBI:34543	17260(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	AVP induces myogenesis through the transcriptional activation of the myocyte_enhancer_factor_2 .
434155	0	AVP	11,14	renin	35,40	AVP	renin	CHEBI:34543	403838(Tax:9615)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|compound|END_ENTITY	Effects of AVP and DDAVP on plasma renin activity and electrolyte excretion in conscious dogs .
20093202	0	AW-814141	27,36	p38	96,99	AW-814141	p38	MESH:C550460	1432	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|MAP MAP|amod|END_ENTITY	Pharmacological profile of AW-814141 , a novel , potent , selective and orally active inhibitor of p38 MAP kinase .
15655539	0	AW464	41,46	thioredoxin	69,80	AW464	thioredoxin	MESH:C515226	7295	Chemical	Gene	activity|nmod|START_ENTITY activity|appos|inhibitor inhibitor|compound|END_ENTITY	Cytotoxic and antiangiogenic activity of AW464 -LRB- NSC_706704 -RRB- , a novel thioredoxin inhibitor : an in vitro study .
10748266	0	AY4166	64,70	PEPT1	96,101	AY4166	PEPT1	MESH:C060142	6564	Chemical	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Inhibitory effect of novel oral hypoglycemic agent nateglinide -LRB- AY4166 -RRB- on peptide transporters PEPT1 and PEPT2 .
22623209	0	AZ64	0,4	TrkB	14,18	AZ64	TrkB	null	4915	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	AZ64 inhibits TrkB and enhances the efficacy of chemotherapy and local radiation in neuroblastoma xenografts .
16397259	0	AZ703	0,5	cyclin-dependent_kinases_1_and_2	46,78	AZ703	cyclin-dependent kinases 1 and 2	null	983;1017	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	AZ703 , an imidazo -LSB- 1,2-a -RSB- pyridine inhibitor of cyclin-dependent_kinases_1_and_2 , induces E2F-1-dependent apoptosis enhanced by depletion of cyclin-dependent_kinase_9 .
21175581	0	AZ876	42,47	liver_X_receptor	16,32	AZ876	liver X receptor	MESH:C559287	22259(Tax:10090)	Chemical	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	Low dose of the liver_X_receptor agonist , AZ876 , reduces atherosclerosis in APOE * 3Leiden mice without affecting liver or plasma triglyceride levels .
18775810	0	AZ960	31,36	JAK2	15,19	AZ960	JAK2	MESH:C534391	3717	Chemical	Gene	Effects|appos|START_ENTITY Effects|nmod|inhibitor inhibitor|compound|END_ENTITY	Effects of the JAK2 inhibitor , AZ960 , on Pim/BAD/BCL-xL survival signaling in the human JAK2 V617F cell line SET-2 .
18775810	0	AZ960	31,36	JAK2	88,92	AZ960	JAK2	MESH:C534391	3717	Chemical	Gene	Effects|appos|START_ENTITY Effects|nmod|survival survival|acl|signaling signaling|nmod|SET-2 SET-2|compound|END_ENTITY	Effects of the JAK2 inhibitor , AZ960 , on Pim/BAD/BCL-xL survival signaling in the human JAK2 V617F cell line SET-2 .
21159615	0	AZ960	0,5	Jak2	15,19	AZ960	Jak2	MESH:C534391	3717	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	AZ960 , a novel Jak2 inhibitor , induces growth_arrest and apoptosis in adult_T-cell_leukemia cells .
21347717	0	AZA	28,31	Syk	16,19	AZA	Syk	null	20963(Tax:10090)	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Reactivation of Syk gene by AZA suppresses metastasis but not proliferation of breast_cancer cells .
24085685	0	AZA-deoxycytidine	0,17	proopiomelanocortin	29,48	AZA-deoxycytidine	proopiomelanocortin	null	5443	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	AZA-deoxycytidine stimulates proopiomelanocortin gene expression and ACTH secretion in human pituitary ACTH-secreting tumors .
26277432	0	AZD-2281	39,47	PARP	23,27	AZD-2281	PARP	MESH:C531550	142	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	In vivo studies of the PARP inhibitor , AZD-2281 , in combination with fractionated radiotherapy : An exploration of the therapeutic ratio .
19586423	0	AZD-4818	0,8	CCR1	22,26	AZD-4818	CCR1	MESH:C546512	1230	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	AZD-4818 , a chemokine CCR1 antagonist : WO2008103126 and WO2009011653 .
26897748	0	AZD-8055	75,83	mTORC1/2	93,101	AZD-8055	mTORC1/2	MESH:C546624	74343;382056	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	C6_ceramide sensitizes the anti-hepatocellular_carcinoma -LRB- HCC -RRB- activity by AZD-8055 , a novel mTORC1/2 dual inhibitor .
18679417	0	AZD0530	85,92	Src	0,3	AZD0530	Src	MESH:C515233	6714	Chemical	Gene	revealed|nmod|START_ENTITY kinase|advcl|revealed kinase|nsubj|family family|compound|END_ENTITY	Src family kinase oncogenic potential and pathways in prostate_cancer as revealed by AZD0530 .
19393585	0	AZD0530	66,73	Src	52,55	AZD0530	Src	MESH:C515233	83805(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|activity activity|nmod|inhibitor inhibitor|compound|END_ENTITY	Preclinical anticancer activity of the potent , oral Src inhibitor AZD0530 .
19509160	0	AZD0530	48,55	Src	59,62	AZD0530	Src	MESH:C515233	6714	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Antitumor effects and biomarkers of activity of AZD0530 , a Src inhibitor , in pancreatic_cancer .
19775203	0	AZD0530	49,56	Src	15,18	AZD0530	Src	MESH:C515233	6714	Chemical	Gene	saracatinib|appos|START_ENTITY saracatinib|compound|END_ENTITY	Effects of the Src kinase inhibitor saracatinib -LRB- AZD0530 -RRB- on bone turnover in healthy men : a randomized , double-blind , placebo-controlled , multiple-ascending-dose phase I trial .
20682712	0	AZD0530	89,96	Src	101,104	AZD0530	Src	MESH:C515233	6714	Chemical	Gene	activity|appos|START_ENTITY activity|appos|inhibitor inhibitor|compound|END_ENTITY	Gene array and fluorescence in situ hybridization biomarkers of activity of saracatinib -LRB- AZD0530 -RRB- , a Src inhibitor , in a preclinical model of colorectal_cancer .
20683035	0	AZD0530	42,49	Src	15,18	AZD0530	Src	MESH:C515233	6714	Chemical	Gene	Effects|appos|START_ENTITY Effects|nmod|saracatinib saracatinib|compound|END_ENTITY	Effects of the Src inhibitor saracatinib -LRB- AZD0530 -RRB- on renal function in healthy subjects .
21170669	0	AZD0530	53,60	Src	26,29	AZD0530	Src	MESH:C515233	6714	Chemical	Gene	study|appos|START_ENTITY study|nmod|saracatinib saracatinib|compound|END_ENTITY	A phase I/II study of the Src inhibitor saracatinib -LRB- AZD0530 -RRB- in combination with gemcitabine in advanced pancreatic_cancer .
21400081	0	AZD0530	58,65	Src	24,27	AZD0530	Src	MESH:C515233	6714	Chemical	Gene	saracatinib|appos|START_ENTITY saracatinib|compound|END_ENTITY	A phase II trial of the Src kinase inhibitor saracatinib -LRB- AZD0530 -RRB- in patients with metastatic or locally advanced gastric or gastro esophageal junction -LRB- GEJ -RRB- adenocarcinoma : a trial of the PMH phase II consortium .
22415795	0	AZD0530	104,111	Src	70,73	AZD0530	Src	MESH:C515233	6714	Chemical	Gene	report|appos|START_ENTITY report|nmod|safety safety|nmod|saracatinib saracatinib|compound|END_ENTITY	First report of the safety , tolerability , and pharmacokinetics of the Src kinase inhibitor saracatinib -LRB- AZD0530 -RRB- in Japanese patients with advanced solid tumours .
26009269	0	AZD0530	33,40	Src	45,48	AZD0530	Src	MESH:C515233	6714	Chemical	Gene	study|appos|START_ENTITY study|appos|inhibitor inhibitor|compound|END_ENTITY	A phase II study of saracatinib -LRB- AZD0530 -RRB- , a Src inhibitor , administered orally daily to patients with advanced thymic malignancies .
20076850	0	AZD0837	97,104	thrombin	78,86	AZD0837	thrombin	MESH:C551586	2147	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|Safety Safety|nmod|formulation formulation|nmod|END_ENTITY	Safety and tolerability of an immediate-release formulation of theoral direct thrombin inhibitor AZD0837 in the prevention of stroke and systemic embolism in patients with atrial_fibrillation .
20528001	0	AZD0837	11,18	thrombin	35,43	AZD0837	thrombin	MESH:C551586	2147	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Effects of AZD0837 , a novel direct thrombin inhibitor , on the electrophysiological properties of the human heart : a randomized , double-blind , parallel-group , placebo-controlled study .
21172721	0	AZD0837	161,168	thrombin	12,20	AZD0837	thrombin	MESH:C551586	2147	Chemical	Gene	study|nmod|START_ENTITY AZD0837|dep|study AZD0837|compound|END_ENTITY	Oral direct thrombin inhibitor AZD0837 for the prevention of stroke and systemic embolism in patients with non-valvular atrial_fibrillation : a Phase II study of AZD0837 in patients who are appropriate for but unable or unwilling to take vitamin_K antagonist therapy .
21429440	0	AZD0837	61,68	thrombin	90,98	AZD0837	thrombin	MESH:C551586	2147	Chemical	Gene	pharmacodynamics|nmod|START_ENTITY pharmacokinetics|appos|pharmacodynamics pharmacokinetics|appos|inhibitor inhibitor|compound|END_ENTITY	Single-dose pharmacokinetics , pharmacodynamics and safety of AZD0837 , a novel oral direct thrombin inhibitor , in young healthy male subjects .
17575233	0	AZD1152	0,7	Aurora_B	34,42	AZD1152	Aurora B	MESH:C520647	9212	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|kinase kinase|compound|END_ENTITY	AZD1152 , a selective inhibitor of Aurora_B kinase , inhibits human tumor xenograft growth by inducing apoptosis .
21371446	0	AZD1152	11,18	Aurora_B	32,40	AZD1152	Aurora B	MESH:C520647	9212	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Effects of AZD1152 , a selective Aurora_B kinase inhibitor , on Burkitt 's and Hodgkin 's _ lymphomas .
27091351	0	AZD1152	16,23	Aurora_B	57,65	AZD1152	Aurora B	MESH:C520647	9212	Chemical	Gene	START_ENTITY|nmod|treatment treatment|nmod|END_ENTITY	Significance of AZD1152 as a potential treatment against Aurora_B overexpression in acute_promyelocytic_leukemia .
19276280	0	AZD1152	87,94	CPT-11	27,33	AZD1152	CPT-11	MESH:C520647	963084(Tax:115711)	Chemical	Gene	effect|nmod|START_ENTITY enhances|dobj|effect enhances|nsubj|END_ENTITY	The topoisomerase I poison CPT-11 enhances the effect of the aurora B kinase inhibitor AZD1152 both in vitro and in vivo .
27054578	0	AZD1208	101,108	Pim	79,82	AZD1208	Pim	MESH:C587575	5292	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Protein profiling identifies mTOR pathway modulation and cytostatic effects of Pim kinase inhibitor , AZD1208 , in acute_myeloid_leukemia .
22306193	0	AZD1236	44,51	MMP-9	19,24	AZD1236	MMP-9	null	4318	Chemical	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of an oral MMP-9 and -12 inhibitor , AZD1236 , on biomarkers in moderate/severe COPD : a randomised controlled trial .
22355274	0	AZD1480	51,58	Jak1/2	33,39	AZD1480	Jak1/2	MESH:C545606	16451;16452	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Comparisons of the efficacy of a Jak1/2 inhibitor -LRB- AZD1480 -RRB- with a VEGF signaling inhibitor -LRB- cediranib -RRB- and sham treatments in mouse tumors using DCE-MRI , DW-MRI , and histology .
25131802	0	AZD1480	41,48	Janus_kinases_1_and_2	66,87	AZD1480	Janus kinases 1 and 2	MESH:C545606	3716;3717	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Initial solid_tumor testing -LRB- stage 1 -RRB- of AZD1480 , an inhibitor of Janus_kinases_1_and_2 by the pediatric preclinical testing program .
23531921	0	AZD1480	54,61	STAT3	14,19	AZD1480	STAT3	MESH:C545606	20848(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY END_ENTITY|nmod|inhibitor	Inhibition of STAT3 with orally active JAK inhibitor , AZD1480 , decreases tumor growth in Neuroblastoma and Pediatric_Sarcomas In vitro and In vivo .
25964244	0	AZD1775	30,37	Wee1	51,55	AZD1775	Wee1	null	7465	Chemical	Gene	Study|nmod|START_ENTITY Study|appos|Inhibitor Inhibitor|compound|END_ENTITY	Phase I Study of Single-Agent AZD1775 -LRB- MK-1775 -RRB- , a Wee1 Kinase Inhibitor , in Patients With Refractory_Solid_Tumors .
26741166	0	AZD1979	134,141	Melanin_Concentrating_Hormone_Receptor_1	146,186	AZD1979	Melanin Concentrating Hormone Receptor 1	null	207911(Tax:10090)	Chemical	Gene	START_ENTITY|appos|Antagonist Antagonist|compound|END_ENTITY	Discovery of -LRB- 3 - -LRB- 4 - -LRB- 2-Oxa-6-azaspiro -LSB- 3.3 -RSB- heptan-6-ylmethyl -RRB- phenoxy -RRB- azetidin-1-yl -RRB- -LRB- 5 - -LRB- 4-methoxyphenyl -RRB- -1,3,4 - oxadiazol-2-yl -RRB- methanone -LRB- AZD1979 -RRB- , a Melanin_Concentrating_Hormone_Receptor_1 -LRB- MCHr1 -RRB- Antagonist with Favorable Physicochemical Properties .
26358751	0	AZD2014	0,7	mTORC1	25,31	AZD2014	mTORC1	null	382056(Tax:10090)	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|nmod|END_ENTITY	AZD2014 , an Inhibitor of mTORC1 and mTORC2 , Is Highly Effective in ER + Breast_Cancer When Administered Using Intermittent or Continuous Schedules .
23668965	0	AZD2066	100,107	mGluR5	71,77	AZD2066	mGluR5	null	14805(Tax:10090)	Chemical	Gene	occupancy|nmod|START_ENTITY occupancy|amod|END_ENTITY	A positron emission tomography study in healthy volunteers to estimate mGluR5 receptor occupancy of AZD2066 - estimating occupancy in the absence of a reference region .
17505008	0	AZD2171	0,7	keratinocyte_growth_factor_receptor	115,150	AZD2171	keratinocyte growth factor receptor	MESH:C500926	2263	Chemical	Gene	shows|nsubj|START_ENTITY shows|dobj|activity activity|nmod|END_ENTITY	AZD2171 shows potent antitumor activity against gastric_cancer over-expressing fibroblast_growth_factor_receptor_2 / keratinocyte_growth_factor_receptor .
17308057	0	AZD2171	28,35	vascular_endothelial_growth_factor	59,93	AZD2171	vascular endothelial growth factor	MESH:C500926	7422	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|signaling signaling|compound|END_ENTITY	Combining radiotherapy with AZD2171 , a potent inhibitor of vascular_endothelial_growth_factor signaling : pathophysiologic effects and therapeutic benefit .
21825006	0	AZD2281	34,41	PARP-1	14,20	AZD2281	PARP-1	MESH:C531550	142	Chemical	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of PARP-1 by olaparib -LRB- AZD2281 -RRB- increases the radiosensitivity of a lung_tumor xenograft .
15911218	0	AZD3582	0,7	heme_oxygenase-1	18,34	AZD3582	heme oxygenase-1	MESH:C111751	3162	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	AZD3582 increases heme_oxygenase-1 expression and antioxidant activity in vascular endothelial and gastric_mucosal_cells .
26313252	0	AZD3759	47,54	Epidermal_Growth_Factor_Receptor	113,145	AZD3759	Epidermal Growth Factor Receptor	null	1956	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|compound|END_ENTITY	Discovery and Evaluation of Clinical Candidate AZD3759 , a Potent , Oral Active , Central Nervous System-Penetrant , Epidermal_Growth_Factor_Receptor Tyrosine Kinase Inhibitor .
25760602	0	AZD4547	53,60	FGFR1	87,92	AZD4547	FGFR1	MESH:C572463	2260	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	The 1.65 resolution structure of the complex of AZD4547 with the kinase domain of FGFR1 displays exquisite molecular recognition .
20466530	0	AZD4818	37,44	CCR1	48,52	AZD4818	CCR1	MESH:C546512	1230	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Tolerability and efficacy of inhaled AZD4818 , a CCR1 antagonist , in moderate to severe COPD patients .
21638123	0	AZD4877	76,83	Eg5	100,103	AZD4877	Eg5	MESH:C568512	3832	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	A Phase I study to assess the safety , tolerability , and pharmacokinetics of AZD4877 , an intravenous Eg5 inhibitor in patients with advanced solid tumors .
22615058	0	AZD4877	63,70	Eg5	48,51	AZD4877	Eg5	MESH:C568512	3832	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|trial trial|nmod|protein protein|appos|END_ENTITY	A Phase I trial of the kinesin spindle protein -LRB- Eg5 -RRB- inhibitor AZD4877 in patients with solid and lymphoid_malignancies .
25681277	0	AZD5069	36,43	CXCR2	57,62	AZD5069	CXCR2	null	3579	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	The safety and tolerability of oral AZD5069 , a selective CXCR2 antagonist , in patients with moderate-to-severe COPD .
25736418	0	AZD5069	36,43	CXCR2	65,70	AZD5069	CXCR2	null	3579	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Pharmacological Characterization of AZD5069 , a Slowly Reversible CXCR2 antagonist .
26182832	0	AZD5069	44,51	CXCR2	26,31	AZD5069	CXCR2	null	3579	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	The effect of a selective CXCR2 antagonist -LRB- AZD5069 -RRB- on human blood neutrophil count and innate immune functions .
23217964	0	AZD5213	0,7	histamine_H3_receptor	17,38	AZD5213	histamine H3 receptor	null	11255	Chemical	Gene	START_ENTITY|dep|antagonist antagonist|amod|END_ENTITY	AZD5213 : a novel histamine_H3_receptor antagonist permitting high daytime and low nocturnal H3 receptor occupancy , a PET study in human subjects .
22294718	0	AZD5363	28,35	AKT	53,56	AZD5363	AKT	MESH:C575618	207	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Preclinical pharmacology of AZD5363 , an inhibitor of AKT : pharmacodynamics , antitumor activity , and correlation of monotherapy activity with genetic background .
26095475	0	AZD5363	69,76	AKT	84,87	AZD5363	AKT	MESH:C575618	207	Chemical	Gene	limits|nummod|START_ENTITY AZD8931|nmod|limits AZD8931|acl:relcl|feedback feedback|nsubj|induced induced|compound|END_ENTITY	Combining AZD8931 , a novel EGFR/HER2/HER3 signalling inhibitor , with AZD5363 limits AKT inhibitor induced feedback and enhances antitumour efficacy in HER2-amplified breast_cancer models .
26095475	0	AZD5363	69,76	AKT	84,87	AZD5363	AKT	MESH:C575618	207	Chemical	Gene	limits|nummod|START_ENTITY AZD8931|nmod|limits AZD8931|acl:relcl|feedback feedback|nsubj|induced induced|compound|END_ENTITY	Combining AZD8931 , a novel EGFR/HER2/HER3 signalling inhibitor , with AZD5363 limits AKT inhibitor induced feedback and enhances antitumour efficacy in HER2-amplified breast_cancer models .
26998062	0	AZD5363	23,30	AKT	60,63	AZD5363	AKT	MESH:C575618	207	Chemical	Gene	inhibitor|appos|START_ENTITY inhibits|nsubj|inhibitor inhibits|dobj|phosphorylation phosphorylation|nmod|molecules molecules|compound|END_ENTITY	A novel AKT inhibitor , AZD5363 , inhibits phosphorylation of AKT downstream molecules , and activates phosphorylation of mTOR and SMG-1 dependent on the liver_cancer cell type .
26998062	0	AZD5363	23,30	AKT	8,11	AZD5363	AKT	MESH:C575618	207	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	A novel AKT inhibitor , AZD5363 , inhibits phosphorylation of AKT downstream molecules , and activates phosphorylation of mTOR and SMG-1 dependent on the liver_cancer cell type .
26314849	0	AZD5582	39,46	IAP	23,26	AZD5582	IAP	null	248	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	A novel small-molecule IAP antagonist , AZD5582 , draws Mcl-1 down-regulation for induction of apoptosis through targeting of cIAP1 and XIAP in human pancreatic_cancer .
17827008	0	AZD6140	12,19	P2Y12	66,71	AZD6140	P2Y12	MESH:C503700	64805	Chemical	Gene	ATP|nmod|START_ENTITY discovery|nmod|ATP discovery|nmod|antagonist antagonist|compound|END_ENTITY	From ATP to AZD6140 : the discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis .
17980251	0	AZD6140	38,45	P2Y12	65,70	AZD6140	P2Y12	MESH:C503700	64805	Chemical	Gene	platelet_aggregation|nmod|START_ENTITY Inhibition|nmod|platelet_aggregation Inhibition|appos|antagonist antagonist|compound|END_ENTITY	Inhibition of platelet_aggregation by AZD6140 , a reversible oral P2Y12 receptor antagonist , compared with clopidogrel in patients with acute_coronary_syndromes .
19335707	0	AZD6140	19,26	P2Y12	41,46	AZD6140	P2Y12	MESH:C503700	64805	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Bleeding risk with AZD6140 , a reversible P2Y12 receptor antagonist , vs. clopidogrel in patients undergoing coronary artery bypass grafting in the DISPERSE2 trial .
19846210	0	AZD6140	28,35	P2Y_12	10,16	AZD6140	P2Y 12	MESH:C503700	64803(Tax:10116)	Chemical	Gene	antagonist|dobj|START_ENTITY antagonist|nsubj|END_ENTITY	The novel P2Y_12 antagonist AZD6140 rapidly and reversibly reduces platelet activation in diabetic rats .
25541062	0	AZD6244	0,7	ERK1/2	35,41	AZD6244	ERK1/2	MESH:C517975	26417;26413	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|compound|END_ENTITY	AZD6244 inhibits cisplatin-induced ERK1/2 activation and potentiates cisplatin-associated cytotoxicity in K-ras G12D preclinical models .
24939055	0	AZD6244	49,56	MEK1/2	32,38	AZD6244	MEK1/2	MESH:C517975	5604;5605	Chemical	Gene	START_ENTITY|nsubj|activity activity|nmod|inhibitor inhibitor|compound|END_ENTITY	Antitumor activity of selective MEK1/2 inhibitor AZD6244 in combination with PI3K/mTOR inhibitor BEZ235 in gefitinib-resistant NSCLC xenograft models .
24118885	0	AZD7687	49,56	Diacylglycerol_acyltransferase_1	0,32	AZD7687	Diacylglycerol acyltransferase 1	MESH:C578442	8694	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Diacylglycerol_acyltransferase_1 inhibition with AZD7687 alters lipid handling and hormone secretion in the gut with intolerable side effects : a randomized clinical trial .
23116186	0	AZD7687	197,204	diacylglycerol_acyltransferase_1	67,99	AZD7687	diacylglycerol acyltransferase 1	MESH:C578442	8694	Chemical	Gene	dimethylpyrazinecarboxamide_phenylcyclohexylacetic_acid|appos|START_ENTITY leading|nmod|dimethylpyrazinecarboxamide_phenylcyclohexylacetic_acid Design|acl|leading Design|nmod|inhibitors inhibitors|nmod|END_ENTITY	Design and optimization of pyrazinecarboxamide-based inhibitors of diacylglycerol_acyltransferase_1 -LRB- DGAT1 -RRB- leading to a clinical candidate dimethylpyrazinecarboxamide_phenylcyclohexylacetic_acid -LRB- AZD7687 -RRB- .
25172964	0	AZD8055	68,75	TORC1/2	49,56	AZD8055	TORC1/2	MESH:C546624	23373;200186	Chemical	Gene	Inhibitor|appos|START_ENTITY Inhibitor|compound|END_ENTITY	Delineating the mTOR Kinase Pathway Using a Dual TORC1/2 Inhibitor , AZD8055 , in Multiple_Myeloma .
21949121	0	AZD8055	29,36	mTOR	14,18	AZD8055	mTOR	MESH:C546624	21977(Tax:10090)	Chemical	Gene	kinase|nmod|START_ENTITY kinase|compound|END_ENTITY	Inhibition of mTOR kinase by AZD8055 can antagonize chemotherapy-induced cell death through autophagy induction and down-regulation of p62/sequestosome _ 1 .
24012800	0	AZD8055	97,104	mTORC1/2	119,127	AZD8055	mTORC1/2	MESH:C546624	74343;382056	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	HER2/neu gene amplification determines the sensitivity of uterine_serous_carcinoma cell lines to AZD8055 , a novel dual mTORC1/2 inhibitor .
20028854	0	AZD8055	0,7	mammalian_target_of_rapamycin	72,101	AZD8055	mammalian target of rapamycin	MESH:C546624	2475	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|compound|END_ENTITY	AZD8055 is a potent , selective , and orally bioavailable ATP-competitive mammalian_target_of_rapamycin kinase inhibitor with in vitro and in vivo antitumor activity .
26933507	0	AZD8848	79,86	TLR7	65,69	AZD8848	TLR7	null	51284	Chemical	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	Tolerability in man following inhalation dosing of the selective TLR7 agonist , AZD8848 .
26582900	0	AZD9150	0,7	STAT3	66,71	AZD9150	STAT3	null	6774	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	AZD9150 , a next-generation antisense oligonucleotide inhibitor of STAT3 with early evidence of clinical activity in lymphoma_and_lung_cancer .
25939061	0	AZD9291	52,59	EGFR	100,104	AZD9291	EGFR	null	1956	Chemical	Gene	START_ENTITY|nmod|T790M T790M|compound|END_ENTITY	Acquired EGFR C797S mutation mediates resistance to AZD9291 in non-small cell lung_cancer harboring EGFR T790M .
26473643	0	AZD9291	37,44	EGFR	81,85	AZD9291	EGFR	MESH:C000596361	1956	Chemical	Gene	Resistance|nmod|START_ENTITY Mechanisms|nmod|Resistance Mechanisms|dep|Mutation-Selective Mutation-Selective|appos|Inhibitor Inhibitor|compound|END_ENTITY	Mechanisms of Acquired Resistance to AZD9291 : A Mutation-Selective , Irreversible EGFR Inhibitor .
26612314	0	AZD9291	63,70	EGFR	122,126	AZD9291	EGFR	MESH:C000596361	1956	Chemical	Gene	clearance|nmod|START_ENTITY clearance|nmod|patient patient|acl|presenting presenting|dobj|mutation mutation|compound|END_ENTITY	Rapid clearance of circulating tumor DNA during treatment with AZD9291 of a lung_cancer patient presenting the resistance EGFR T790M mutation .
26716903	0	AZD9291	49,56	EGFR	34,38	AZD9291	EGFR	MESH:C000596361	1956	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|efficacy efficacy|nmod|END_ENTITY	High efficacy of third generation EGFR inhibitor AZD9291 in a leptomeningeal_carcinomatosis model with EGFR-mutant lung_cancer cells .
26958497	0	AZD9291	0,7	EGFR	15,19	AZD9291	EGFR	MESH:C000596361	1956	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	AZD9291 in TKI EGFR resistance in non-small_cell_lung_cancer and the new concept of phase I trials .
27044261	0	AZD9291	0,7	EGFR	69,73	AZD9291	EGFR	MESH:C000596361	1956	Chemical	Gene	T790|compound|START_ENTITY __|nsubj|T790 __|nmod|degradation degradation|nmod|END_ENTITY	AZD9291 overcomes T790 __ M-mediated resistance through degradation of EGFR -LRB- L858R/T790M -RRB- in non-small_cell_lung_cancer cells .
26958499	0	AZD9291	0,7	epidermal_growth_factor_receptor	11,43	AZD9291	epidermal growth factor receptor	MESH:C000596361	1956	Chemical	Gene	START_ENTITY|nmod|lung_cancer lung_cancer|compound|END_ENTITY	AZD9291 in epidermal_growth_factor_receptor inhibitor-resistant non-small-cell lung_cancer .
27020862	0	AZD9496	0,7	estrogen_receptor	17,34	AZD9496	estrogen receptor	null	2099	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	AZD9496 : An oral estrogen_receptor inhibitor that blocks the growth of ER-positive and ESR1 mutant breast_tumours in preclinical models .
26524020	0	AZT	32,35	TGF-b	93,98	AZT	TGF-b	D015215	7040	Chemical	Gene	Effect|nmod|START_ENTITY Effect|acl|END_ENTITY	-LSB- Effect of Emodin Combined with AZT on the Proliferation and the Expression of BCL-2 , NF-kB , TGF-b in the Leukemia Stem Cells-KG-1a cells -RSB- .
15379215	0	A_771726	0,8	TNF-alpha	57,66	A 771726	TNF-alpha	MESH:C072876	24835(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	A_771726 , the active metabolite of leflunomide , inhibits TNF-alpha and IL-1 from Kupffer cells .
17360334	0	A_porphomethene	0,15	uroporphyrinogen_decarboxylase	29,59	A porphomethene	uroporphyrinogen decarboxylase	null	7389	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|nmod|END_ENTITY	A_porphomethene inhibitor of uroporphyrinogen_decarboxylase causes porphyria cutanea_tarda .
16480688	0	Aaptamine	0,9	p21	42,45	Aaptamine	p21	MESH:C043986	644914	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|promoter promoter|amod|END_ENTITY	Aaptamine , a spongean alkaloid , activates p21 promoter in a p53-independent manner .
8819005	0	Abbott-79175	45,57	5-lipoxygenase	79,93	Abbott-79175	5-lipoxygenase	MESH:C082739	240	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Polymorphism and crystallization behavior of Abbott-79175 , a second-generation 5-lipoxygenase inhibitor .
20441772	0	Abeta25-35	13,23	CA1	114,117	Abeta25-35	CA1	MESH:C074636	310218(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Oligomerized Abeta25-35 induces increased tyrosine phosphorylation of NMDA receptor subunit 2A in rat hippocampal CA1 subfield .
20686698	0	Abeta42	76,83	Low-density_lipoprotein_receptor-related_protein_1	0,50	Abeta42	Low-density lipoprotein receptor-related protein 1	null	16971(Tax:10090)	Chemical	Gene	uptake|amod|START_ENTITY mediates|dobj|uptake mediates|nsubj|END_ENTITY	Low-density_lipoprotein_receptor-related_protein_1 -LRB- LRP1 -RRB- mediates neuronal Abeta42 uptake and lysosomal trafficking .
25496486	0	Abietic_acid	0,12	MMP-1	34,39	Abietic acid	MMP-1	MESH:C023710	4312	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Abietic_acid inhibits UVB-induced MMP-1 expression in human dermal fibroblast cells through PPARa/y dual activation .
11807975	0	Abietic_acid	0,12	lipoxygenase	22,34	Abietic acid	lipoxygenase	MESH:C023710	547836(Tax:3847)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Abietic_acid inhibits lipoxygenase activity .
12935909	0	Abietic_acid	0,12	peroxisome_proliferator-activated_receptor-gamma	23,71	Abietic acid	peroxisome proliferator-activated receptor-gamma	MESH:C023710	5468	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Abietic_acid activates peroxisome_proliferator-activated_receptor-gamma -LRB- PPARgamma -RRB- in RAW264 .7 macrophages and 3T3-L1 adipocytes to regulate gene expression involved in inflammation and lipid metabolism .
6779098	0	Aborigines	90,100	thyroxine-binding_globulin	42,68	Aborigines	thyroxine-binding globulin	null	6906	Chemical	Gene	levels|nmod|START_ENTITY levels|amod|END_ENTITY	Distribution and inheritance of low serum thyroxine-binding_globulin levels in Australian Aborigines : a new genetic variation .
18955274	0	Abrin	83,88	Caspase-3	14,23	Abrin	Caspase-3	null	12367(Tax:10090)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|Expression Expression|amod|END_ENTITY	Regulation of Caspase-3 and Bcl-2 Expression in Dalton 's _ Lymphoma Ascites Cells by Abrin .
26708041	0	Abscisic_Acid	38,51	ABI4	0,4	Abscisic Acid	ABI4	MESH:D000040	818614(Tax:3702)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|compound|END_ENTITY	ABI4 Mediates Antagonistic Effects of Abscisic_Acid and Gibberellins at Transcript and Protein Levels .
26410794	0	Abscisic_Acid	0,13	ACS4	102,106	Abscisic Acid	ACS4	MESH:D000040	816812(Tax:3702)	Chemical	Gene	Production|compound|START_ENTITY Production|nmod|END_ENTITY	Abscisic_Acid Antagonizes Ethylene Production through the ABI4-Mediated Transcriptional Repression of ACS4 and ACS8 in Arabidopsis .
26488296	0	Abscisic_Acid	0,13	Glucagon-Like_Peptide-1	25,48	Abscisic Acid	Glucagon-Like Peptide-1	MESH:D000040	24952(Tax:10116)	Chemical	Gene	Secretion|compound|START_ENTITY Secretion|compound|END_ENTITY	Abscisic_Acid Stimulates Glucagon-Like_Peptide-1 Secretion from L-Cells and Its Oral Administration Increases Plasma Glucagon-Like_Peptide-1 Levels in Rats .
16667311	0	Abscissic_Acid	110,124	Glb1	97,101	Abscissic Acid	Glb1	MESH:D000040	732801(Tax:4577)	Chemical	Gene	Gene|nmod|START_ENTITY Gene|compound|END_ENTITY	Globulin Gene Expression in Embryos of Maize viviparous Mutants : Evidence for Regulation of the Glb1 Gene by Abscissic_Acid .
18378144	0	Ac-DMQD-CHO	24,35	caspase_3	39,48	Ac-DMQD-CHO	caspase 3	MESH:C110922	25402(Tax:10116)	Chemical	Gene	efficacy|nmod|START_ENTITY efficacy|appos|inhibitor inhibitor|amod|END_ENTITY	Therapeutic efficacy of Ac-DMQD-CHO , a caspase_3 inhibitor , for rat spinal_cord_injury .
17594508	0	Ac-DNLD-CHO	88,99	caspase-3	67,76	Ac-DNLD-CHO	caspase-3	null	836	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Structural_and_functional_definition of the specificity of a novel caspase-3 inhibitor , Ac-DNLD-CHO .
26945075	0	Ac-SDKP	0,7	ICAM-1	32,38	Ac-SDKP	ICAM-1	MESH:C058504	3383	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Ac-SDKP Suppresses TNFa-induced ICAM-1 Expression in Endothelial Cells via Inhibition of IkB Kinase and NF-kB Activation .
26785300	0	Ac-SDKP	21,28	TGF-b1	88,94	Ac-SDKP	TGF-b1	MESH:C058504	59086(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Protective effect of Ac-SDKP on alveolar epithelial cells through inhibition of EMT via TGF-b1 / ROCK1 pathway in silicosis in rat .
26098610	0	Ac-SDKP	51,58	thymosin_b4	11,22	Ac-SDKP	thymosin b4	MESH:C058504	19241(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of thymosin_b4 and its N-terminal fragment Ac-SDKP on TGF-b-treated human lung fibroblasts and in the mouse model of bleomycin-induced lung_fibrosis .
26962108	0	Ac-SDKP	30,37	thymosin_b4	55,66	Ac-SDKP	thymosin b4	MESH:C058504	19241(Tax:10090)	Chemical	Gene	released|nsubjpass|START_ENTITY released|nmod|END_ENTITY	The anti-inflammatory peptide Ac-SDKP is released from thymosin_b4 by renal meprin a and prolyl_oligopeptidase .
25331424	0	Ac-tLeu-Asp-H	0,13	caspase-3	56,65	Ac-tLeu-Asp-H	caspase-3	null	836	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|amod|END_ENTITY	Ac-tLeu-Asp-H is the minimal and highly effective human caspase-3 inhibitor : biological and in silico studies .
23397569	0	AcStefin	29,37	Cysteine_protease	0,17	AcStefin	Cysteine protease	null	1508	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Cysteine_protease inhibitor -LRB- AcStefin -RRB- is required for complete cyst formation of Acanthamoeba .
23855486	0	Acacetin	0,8	E-selectin	32,42	Acacetin	E-selectin	MESH:C023717	6401	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Acacetin inhibits expression of E-selectin on endothelial cells through regulation of the MAP kinase signaling pathway and activation of NF-kB .
20492175	0	Acacetin	0,8	MMP-2	30,35	Acacetin	MMP-2	MESH:C023717	4313	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Acacetin inhibits TPA-induced MMP-2 and u-PA expressions of human lung_cancer cells through inactivating JNK signaling pathway and reducing binding activities of NF-kappaB and AP-1 .
7877305	0	Acadesine	0,9	CD11b	30,35	Acadesine	CD11b	MESH:C011651	3684	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|up-regulation up-regulation|amod|END_ENTITY	Acadesine inhibits neutrophil CD11b up-regulation in vitro and during in vivo cardiopulmonary bypass .
26957112	0	Acalabrutinib	0,13	BTK	55,58	Acalabrutinib	BTK	null	695	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Acalabrutinib -LRB- ACP-196 -RRB- : a selective second-generation BTK inhibitor .
15026281	0	Acanthoic_acid	0,14	IL-8	24,28	Acanthoic acid	IL-8	MESH:C099958	3576	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	Acanthoic_acid inhibits IL-8 production via MAPKs and NF-kappaB in a TNF-alpha-stimulated human intestinal epithelial cell line .
26803523	0	Acanthoic_acid	0,14	LXRa	72,76	Acanthoic acid	LXRa	MESH:C099958	10062	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|activating activating|dobj|END_ENTITY	Acanthoic_acid inhibits LPS-induced inflammatory response by activating LXRa in human umbilical vein endothelial cells .
14686965	1	Acarbose	143,151	glucose	155,162	Acarbose	insulin	MESH:D020909	3630	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	AIM : Acarbose , a glucose oxidase inhibitor , delays the absorption of glucose thus reducing post-prandial blood glucose level , haemoglobin A1c -LRB- HbA1c -RRB- and insulin resistance in patients with diabetes_mellitus and in subjects with impaired_glucose_tolerance .
11965830	8	Acarbose	1108,1116	insulin	1163,1170	Acarbose	insulin	MESH:D020909	3630	Chemical	Gene	START_ENTITY|acl:relcl|shown shown|xcomp|reduce reduce|dobj|secretion secretion|compound|END_ENTITY	Acarbose , which has been shown to reduce post-prandial insulin secretion and improve insulin resistance , is being assessed in the STOP-NIDDM trial .
12149599	0	Acarbose	0,8	insulin	34,41	Acarbose	insulin	MESH:D020909	3630	Chemical	Gene	improves|nsubj|START_ENTITY improves|dobj|resistance resistance|compound|END_ENTITY	Acarbose improves indirectly both insulin resistance and secretion in obese_type_2 diabetic patients .
17924867	0	Acarbose	0,8	insulin	85,92	Acarbose	insulin	MESH:D020909	3630	Chemical	Gene	control|amod|START_ENTITY diabetes|nsubj|control diabetes|nmod|therapy therapy|compound|END_ENTITY	Acarbose and metabolic control in patients with type 2 diabetes with newly initiated insulin therapy .
17133782	0	Acarbose	0,8	monocyte_chemoattractant_protein-1	95,129	Acarbose	monocyte chemoattractant protein-1	MESH:D020909	24770(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|nmod|END_ENTITY	Acarbose , an alpha-glucosidase inhibitor , decreases aortic gene expression and serum levels of monocyte_chemoattractant_protein-1 in fructose-fed rats .
25590368	0	Aceroside_VIII	0,14	HDAC6	42,47	Aceroside VIII	HDAC6	null	10013	Chemical	Gene	Inhibitor|nsubj|START_ENTITY Inhibitor|compound|END_ENTITY	Aceroside_VIII is a New Natural Selective HDAC6 Inhibitor that Synergistically Enhances the Anticancer Activity of HDAC Inhibitor in HT29 Cells .
21284671	0	Acetaldehyde	0,12	ADH1B	33,38	Acetaldehyde	ADH1B	MESH:D000079	125	Chemical	Gene	protection|amod|START_ENTITY protection|nmod|END_ENTITY	Acetaldehyde burst protection of ADH1B * 2 against alcoholism : an additional hormesis protection against esophageal_cancers following alcohol consumption ?
12893455	0	Acetaldehyde	0,12	ALDH	47,51	Acetaldehyde	ALDH	MESH:D000079	25375(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|nmod|END_ENTITY	Acetaldehyde metabolism by liver mitochondrial ALDH from UChA and UChB rats : effect of inhibitors .
20506324	0	Acetaldehyde	0,12	ERK	21,24	Acetaldehyde	ERK	MESH:D000079	24338(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Acetaldehyde elicits ERK phosphorylation in the rat nucleus accumbens and extended amygdala .
17030193	0	Acetaldehyde	0,12	PPARgamma	22,31	Acetaldehyde	PPARgamma	MESH:D000079	5468	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Acetaldehyde inhibits PPARgamma via H2O2-mediated c-Abl activation in human hepatic stellate cells .
8060517	0	Acetaldehyde	0,12	alpha_1-antitrypsin	52,71	Acetaldehyde	alpha 1-antitrypsin	MESH:D000079	5265	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	Acetaldehyde inhibits the anti-elastase activity of alpha_1-antitrypsin .
17543481	0	Acetaldehyde	0,12	matrix_metalloproteinase-9	21,47	Acetaldehyde	matrix metalloproteinase-9	MESH:D000079	4318	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Acetaldehyde induces matrix_metalloproteinase-9 gene expression via nuclear factor-kappaB and activator_protein_1 signaling pathways in human hepatocellular_carcinoma cells : Association with the invasive potential .
10513995	0	Acetaldehyde	0,12	urokinase_type_plasminogen_activator	59,95	Acetaldehyde	urokinase type plasminogen activator	MESH:D000079	5328	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Acetaldehyde increases the activity and gene expression of urokinase_type_plasminogen_activator in a hepatic stellate cell line .
24250423	0	Acetaminophen	109,122	MRP2	32,36	Acetaminophen	MRP2	MESH:D000082	25303(Tax:10116)	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of Drug Pump Protein MRP2 in Lipopolysaccharide-Treated Rats and its Impact on the Disposition of Acetaminophen .
9918139	0	Acetaminophen	0,13	N-acetyltransferase_2	41,62	Acetaminophen	N-acetyltransferase 2	MESH:D000082	10	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Acetaminophen is an inhibitor of hepatic N-acetyltransferase_2 in vitro and in vivo .
24019224	0	Acetaminophen	0,13	P-glycoprotein	24,38	Acetaminophen	P-glycoprotein	MESH:D000082	5243	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|functional functional|amod|END_ENTITY	Acetaminophen modulates P-glycoprotein functional expression at the blood-brain barrier by a constitutive_androstane_receptor-dependent mechanism .
17884974	0	Acetaminophen	0,13	cyclooxygenase-2	43,59	Acetaminophen	cyclooxygenase-2	MESH:D000082	5743	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|amod|END_ENTITY	Acetaminophen -LRB- paracetamol -RRB- is a selective cyclooxygenase-2 inhibitor in man .
23897240	0	Acetaminophen	0,13	p-glycoprotein	34,48	Acetaminophen	p-glycoprotein	MESH:D000082	287115(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Acetaminophen inhibits intestinal p-glycoprotein transport activity .
7072453	0	Acetate	0,7	growth_hormone	22,36	Acetate	growth hormone	CHEBI:47622	2688	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|hypersecretion hypersecretion|amod|END_ENTITY	Acetate : inhibitor of growth_hormone hypersecretion in diabetic and non-diabetic uraemic subjects .
7125955	0	Acetate	0,7	growth_hormone	19,33	Acetate	growth hormone	CHEBI:47622	2688	Chemical	Gene	secretion|amod|START_ENTITY secretion|compound|END_ENTITY	Acetate suppresses growth_hormone secretion in uremic patients : hemodialysis and acetate infusion experiments .
15169637	0	Acetazolamide	0,13	aquaporin-1	23,34	Acetazolamide	aquaporin-1	MESH:D000086	11826(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Acetazolamide inhibits aquaporin-1 protein expression and angiogenesis .
16480680	0	Acetazolamide	0,13	aquaporin-1	70,81	Acetazolamide	aquaporin-1	MESH:D000086	358	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|interaction interaction|nmod|END_ENTITY	Acetazolamide inhibits osmotic water permeability by interaction with aquaporin-1 .
21940319	0	Acetazolamide	0,13	aquaporin-1	23,34	Acetazolamide	aquaporin-1	MESH:D000086	11826(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Acetazolamide inhibits aquaporin-1 expression and colon_cancer xenograft tumor growth .
6128982	0	Acetazolamide	0,13	gamma-glutamyl_transpeptidase	34,63	Acetazolamide	gamma-glutamyl transpeptidase	MESH:D000086	92086	Chemical	Gene	START_ENTITY|dobj|inhibition inhibition|nmod|END_ENTITY	Acetazolamide inhibition of renal gamma-glutamyl_transpeptidase .
16630552	0	Acetic_acid	0,11	AMPK	30,34	Acetic acid	AMPK	MESH:D019342	78975(Tax:10116)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Acetic_acid activates hepatic AMPK and reduces hyperglycemia in diabetic KK-A -LRB- y -RRB- mice .
12435474	0	Acetoacetate	0,12	ICAM-1	72,78	Acetoacetate	ICAM-1	MESH:C016635	3383	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Acetoacetate increases expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- in human brain microvascular endothelial cells .
12106279	0	Acetorphan	0,10	Enkephalinase	15,28	Acetorphan	Enkephalinase	MESH:C049331	24590(Tax:10116)	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|compound|END_ENTITY	Acetorphan , an Enkephalinase Inhibitor , Modulates Dopaminergic Transmission in Rat Olfactory Tubercle , but not in the Nucleus Accumbens and Striatum .
20302919	0	Acetyl-L-carnitine	0,18	artemin	29,36	Acetyl-L-carnitine	artemin	MESH:D000108	362572(Tax:10116)	Chemical	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	Acetyl-L-carnitine increases artemin level and prevents neurotrophic_factor alterations during neuropathy .
7793306	0	Acetyl-L-carnitine	0,18	choline_acetyltransferase	28,53	Acetyl-L-carnitine	choline acetyltransferase	MESH:D000108	290567(Tax:10116)	Chemical	Gene	restores|amod|START_ENTITY END_ENTITY|nsubj|restores	Acetyl-L-carnitine restores choline_acetyltransferase activity in the hippocampus of rats with partial unilateral fimbria-fornix transection .
8137174	0	Acetyl-L-carnitine	0,18	choline_acetyltransferase	39,64	Acetyl-L-carnitine	choline acetyltransferase	MESH:D000108	290567(Tax:10116)	Chemical	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	Acetyl-L-carnitine treatment increases choline_acetyltransferase activity and NGF levels in the CNS of adult rats following total fimbria-fornix transection .
8187841	0	Acetyl-L-carnitine	0,18	nerve_growth_factor	39,58	Acetyl-L-carnitine	nerve growth factor	MESH:D000108	310738(Tax:10116)	Chemical	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	Acetyl-L-carnitine treatment increases nerve_growth_factor levels and choline_acetyltransferase activity in the central nervous system of aged rats .
12842278	0	Acetyl-RYYRIK-NH2	0,17	orphanin_FQ	31,42	Acetyl-RYYRIK-NH2	orphanin FQ	MESH:C118945	25516(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Acetyl-RYYRIK-NH2 , a purported orphanin_FQ antagonist , does not block the orphanin_FQ-induced prolactin secretory response in female rats .
21742782	0	Acetyl_tributyl_citrate	0,23	steroid_and_xenobiotic_receptor	115,146	Acetyl tributyl citrate	steroid and xenobiotic receptor	MESH:C014953	8856	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Acetyl_tributyl_citrate , the most widely used phthalate substitute plasticizer , induces cytochrome p450 3a through steroid_and_xenobiotic_receptor .
7945297	0	Acetylcarnitine	0,15	alcohol_dehydrogenase	25,46	Acetylcarnitine	alcohol dehydrogenase	MESH:D000108	78959(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Acetylcarnitine inhibits alcohol_dehydrogenase .
27023866	0	Acetylcholine	93,106	Adiponectin	0,11	Acetylcholine	Adiponectin	MESH:D000109	9370	Chemical	Gene	Effect|nmod|START_ENTITY Enhances|dobj|Effect Enhances|nsubj|END_ENTITY	Adiponectin at Physiologically Relevant Concentrations Enhances the Vasorelaxative Effect of Acetylcholine via Cav-1 / AdipoR-1 Signaling .
25278874	0	Acetylcholine	0,13	CA1	73,76	Acetylcholine	CA1	MESH:D000109	12346(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|activity activity|nmod|END_ENTITY	Acetylcholine release and inhibitory interneuron activity in hippocampal CA1 .
25918499	0	Acetylcholine	0,13	CA1	43,46	Acetylcholine	CA1	MESH:D000109	12346(Tax:10090)	Chemical	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	Acetylcholine release in mouse hippocampal CA1 preferentially activates inhibitory-selective interneurons via a4b2 * nicotinic receptor activation .
25918499	0	Acetylcholine	0,13	CA1	43,46	Acetylcholine	CA1	MESH:D000109	12346(Tax:10090)	Chemical	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	Acetylcholine release in mouse hippocampal CA1 preferentially activates inhibitory-selective interneurons via a4b2 * nicotinic receptor activation .
11037885	0	Acetylcholine	0,13	CD54	58,62	Acetylcholine	CD54	MESH:D000109	3383	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|dobj|END_ENTITY	Acetylcholine prevents intercellular adhesion molecule 1 -LRB- CD54 -RRB- - induced focal adhesion complex assembly in endothelial cells via a nitric_oxide-cGMP-dependent pathway .
25352454	0	Acetylcholine	42,55	CD68	20,24	Acetylcholine	CD68	MESH:D000109	12514(Tax:10090)	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Temporal Changes of CD68 and a7 Nicotinic Acetylcholine Receptor Expression in Microglia in Alzheimer 's _ Disease-Like Mouse Models .
12037167	0	Acetylcholine	0,13	Ca2	38,41	Acetylcholine	Ca2	MESH:D000109	54231(Tax:10116)	Chemical	Gene	increases|amod|START_ENTITY intracellular|nsubj|increases intracellular|dobj|+ +|compound|END_ENTITY	Acetylcholine increases intracellular Ca2 + in taste cells via activation of muscarinic receptors .
26202362	0	Acetylcholine	0,13	MMP-9	35,40	Acetylcholine	MMP-9	MESH:D000109	17395(Tax:10090)	Chemical	Gene	Production|compound|START_ENTITY Production|compound|END_ENTITY	Acetylcholine Inhibits LPS-Induced MMP-9 Production and Cell Migration via the a7 nAChR-JAK2 / STAT3 Pathway in RAW264 .7 Cells .
26202362	0	Acetylcholine	0,13	MMP-9	35,40	Acetylcholine	MMP-9	MESH:D000109	17395(Tax:10090)	Chemical	Gene	Production|compound|START_ENTITY Production|compound|END_ENTITY	Acetylcholine Inhibits LPS-Induced MMP-9 Production and Cell Migration via the a7 nAChR-JAK2 / STAT3 Pathway in RAW264 .7 Cells .
8954631	0	Acetylcholine	110,123	Rapsyn	31,37	Acetylcholine	Rapsyn	MESH:D000109	5913	Chemical	Gene	phosphorylation|compound|START_ENTITY Colocalized|nmod|phosphorylation Phosphorylation|nmod|Colocalized Phosphorylation|compound|END_ENTITY	The Synapse-Associated Protein Rapsyn Regulates Tyrosine Phosphorylation of Proteins Colocalized at Nicotinic Acetylcholine Receptor Clusters Protein tyrosine phosphorylation has been suggested to play an important role in the clustering of the nicotinic acetylcholine receptor -LRB- AChR -RRB- at the developing neuromuscular junction .
8973828	0	Acetylcholine	0,13	acetylcholinesterase	94,114	Acetylcholine	acetylcholinesterase	MESH:D000109	83817(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY release|nmod|cortex cortex|nmod|rat rat|acl|measured measured|nmod|inhibitors inhibitors|amod|END_ENTITY	Acetylcholine release from frontal cortex in the waking rat measured by microdialysis without acetylcholinesterase inhibitors : effects of diisopropylfluorophosphate .
23620780	0	Acetylcholine	0,13	androgen_receptor	22,39	Acetylcholine	androgen receptor	MESH:D000109	367	Chemical	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	Acetylcholine acts on androgen_receptor to promote the migration and invasion but inhibit the apoptosis of human hepatocarcinoma .
19178986	0	Acetylcholine	0,13	apolipoprotein_E	63,79	Acetylcholine	apolipoprotein E	MESH:D000109	11816(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|acl|lacking lacking|dobj|END_ENTITY	Acetylcholine receptor and behavioral_deficits in mice lacking apolipoprotein_E .
9428762	0	Acetylcholine	0,13	beta2	39,44	Acetylcholine	beta2	MESH:D000109	15130(Tax:10090)	Chemical	Gene	receptors|amod|START_ENTITY receptors|acl|containing containing|dobj|subunit subunit|amod|END_ENTITY	Acetylcholine receptors containing the beta2 subunit are involved in the reinforcing properties of nicotine .
17542812	0	Acetylcholine	0,13	choline_acetyltransferase	27,52	Acetylcholine	choline acetyltransferase	MESH:D000109	290567(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY synthesis|nmod|END_ENTITY	Acetylcholine synthesis by choline_acetyltransferase of a peripheral type as demonstrated in adult rat dorsal root ganglion .
2302559	0	Acetylcholine	0,13	corticotropin-releasing_factor	42,72	Acetylcholine	corticotropin-releasing factor	MESH:D000109	81648(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|nmod|END_ENTITY	Acetylcholine stimulates the secretion of corticotropin-releasing_factor from primary dissociated cell cultures of the rat telencephalon and diencephalon .
9606035	0	Acetylcholine	0,13	granulocyte-macrophage_colony_stimulating_factor	52,100	Acetylcholine	granulocyte-macrophage colony stimulating factor	MESH:D000109	1437	Chemical	Gene	stimulate|nsubj|START_ENTITY stimulate|dobj|release release|nmod|END_ENTITY	Acetylcholine and nicotine stimulate the release of granulocyte-macrophage_colony_stimulating_factor from cultured human bronchial epithelial cells .
487284	0	Acetylcholine	0,13	growth_hormone	48,62	Acetylcholine	growth hormone	MESH:D000109	81668(Tax:10116)	Chemical	Gene	stimulate|nsubj|START_ENTITY stimulate|dobj|release release|nmod|END_ENTITY	Acetylcholine does not stimulate the release of growth_hormone from perifused rat adenohypophyses .
8953472	0	Acetylcholine	0,13	growth_hormone	25,39	Acetylcholine	growth hormone	MESH:D000109	81668(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|amod|END_ENTITY	Acetylcholine stimulates growth_hormone secretion in the neonatal rat pituitary .
17662981	0	Acetylcholine	0,13	insulin	78,85	Acetylcholine	insulin	MESH:D000109	3630	Chemical	Gene	exerts|nsubj|START_ENTITY exerts|dobj|effects effects|nmod|END_ENTITY	Acetylcholine exerts additive and permissive but not synergistic effects with insulin on glycogen synthesis in hepatocytes .
6105951	0	Acetylcholine	0,13	insulin	25,32	Acetylcholine	insulin	MESH:D000109	396145(Tax:9031)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Acetylcholine stimulates insulin , glucagon , and somatostatin release in the perfused chicken pancreas .
17325509	0	Acetylcholine	0,13	protein_kinase_C-alpha	24,46	Acetylcholine	protein kinase C-alpha	MESH:D000109	5578	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Acetylcholine activates protein_kinase_C-alpha in pulmonary venous smooth muscle .
15201319	0	Acetylcholine	0,13	rapsyn	31,37	Acetylcholine	rapsyn	MESH:D000109	352942(Tax:7955)	Chemical	Gene	receptors|nsubj|START_ENTITY receptors|dobj|clusters clusters|compound|END_ENTITY	Acetylcholine receptors direct rapsyn clusters to the neuromuscular synapse in zebrafish .
6103801	0	Acetylcholine	0,13	somatostatin	38,50	Acetylcholine	somatostatin	MESH:D000109	24797(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|nmod|END_ENTITY	Acetylcholine inhibits the release of somatostatin from rat hypothalamus in vitro .
20857413	0	Acetylcholine	0,13	tumor_necrosis_factor-a	39,62	Acetylcholine	tumor necrosis factor-a	MESH:D000109	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Acetylcholine inhibits hypoxia-induced tumor_necrosis_factor-a production via regulation of MAPKs phosphorylation in cardiomyocytes .
15366926	0	Acetylcholine	0,13	vesicular_acetylcholine_transporter	34,69	Acetylcholine	vesicular acetylcholine transporter	MESH:D000109	60422(Tax:10116)	Chemical	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Acetylcholine binding site in the vesicular_acetylcholine_transporter .
2371491	0	Acetylsalicylic_acid	0,20	PAI-1	39,44	Acetylsalicylic acid	PAI-1	MESH:D001241	5054	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|compound|END_ENTITY	Acetylsalicylic_acid inhibits platelet PAI-1 antigen release without affecting circulating PAI-1 antigen in plasma .
2371491	0	Acetylsalicylic_acid	0,20	PAI-1	91,96	Acetylsalicylic acid	PAI-1	MESH:D001241	5054	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|affecting affecting|advcl|circulating circulating|dobj|antigen antigen|compound|END_ENTITY	Acetylsalicylic_acid inhibits platelet PAI-1 antigen release without affecting circulating PAI-1 antigen in plasma .
16384847	0	Acetylsalicylic_acid	0,20	insulin	44,51	Acetylsalicylic acid	insulin	MESH:D001241	3630	Chemical	Gene	improves|nsubj|START_ENTITY improves|dobj|resistance resistance|compound|END_ENTITY	Acetylsalicylic_acid improves lipid-induced insulin resistance in healthy men .
2414631	0	Acetylsalicylic_acid	0,20	substance_P	106,117	Acetylsalicylic acid	substance P	MESH:D001241	21333(Tax:10090)	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|nmod|END_ENTITY	Acetylsalicylic_acid , paracetamol and morphine inhibit behavioral responses to intrathecally administered substance_P or capsaicin .
15756839	0	Acibenzolar-S-methyl	11,31	peroxidase	62,72	Acibenzolar-S-methyl	peroxidase	MESH:C099403	101212957	Chemical	Gene	START_ENTITY|nmod|activities activities|nmod|END_ENTITY	Effects of Acibenzolar-S-methyl on the specific activities of peroxidase , chitinase and phenylalanine_ammonia-lyase and phenolic content of host leaves in cucumber-powdery mildew interaction .
22860122	0	Aciculatin	0,10	granulocyte_colony-stimulating_factor	20,57	Aciculatin	granulocyte colony-stimulating factor	MESH:C074400	1440	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Aciculatin inhibits granulocyte_colony-stimulating_factor production by human interleukin 1b-stimulated fibroblast-like synoviocytes .
21548916	0	Aciculatin	0,10	inducible_nitric_oxide_synthase	48,79	Aciculatin	inducible nitric oxide synthase	MESH:C074400	18126(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Aciculatin inhibits lipopolysaccharide-mediated inducible_nitric_oxide_synthase and cyclooxygenase-2 expression via suppressing NF-kB and JNK/p38 MAPK activation pathways .
11085190	0	Acipimox	0,8	growth_hormone	46,60	Acipimox	growth hormone	MESH:C027696	2688	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|amod|END_ENTITY	Acipimox , a nicotinic_acid analog , stimulates growth_hormone secretion in short healthy prepubertal children .
14670810	0	Acipimox	0,8	growth_hormone	30,44	Acipimox	growth hormone	MESH:C027696	2688	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|secretion secretion|compound|END_ENTITY	Acipimox enhances spontaneous growth_hormone secretion in obese women .
18624760	0	Acitretin	0,9	CD95	36,40	Acitretin	CD95	MESH:D017255	355	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Acitretin induces apoptosis through CD95 signalling pathway in human cutaneous_squamous_cell_carcinoma cell line SCL-1 .
20525722	0	Aclidinium	0,10	MUC5AC	58,64	Aclidinium	MUC5AC	CHEBI:65346	4586	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Aclidinium inhibits cholinergic and tobacco smoke-induced MUC5AC in human airways .
22429221	0	Acotiamide	0,10	acetylcholinesterase	32,52	Acotiamide	acetylcholinesterase	MESH:C410959	489828(Tax:9615)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Acotiamide , a new orally active acetylcholinesterase inhibitor , stimulates gastrointestinal motor activity in conscious dogs .
21123674	0	Acotiamide_hydrochloride	0,24	acetylcholinesterase	50,70	Acotiamide hydrochloride	acetylcholinesterase	null	489828(Tax:9615)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Acotiamide_hydrochloride -LRB- Z-338 -RRB- , a new selective acetylcholinesterase inhibitor , enhances gastric_motility without prolonging QT interval in dogs : comparison with cisapride , itopride , and mosapride .
6212085	0	Acridine	1,9	ATPase	35,41	Acridine	ATPase	CHEBI:36420	1769	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|activity activity|amod|END_ENTITY	-LSB- Acridine orange inhibition of the ATPase activity of myosin and its fragments -RSB- .
26168132	0	Acriflavine	29,40	HIF-1	0,5	Acriflavine	HIF-1	MESH:D000167	3091	Chemical	Gene	Activity|compound|START_ENTITY Activity|compound|END_ENTITY	HIF-1 Dimerization Inhibitor Acriflavine Enhances Antitumor Activity of Sunitinib in Breast_Cancer_Model .
20153347	0	Acrolein	0,8	5-lipoxygenase	19,33	Acrolein	5-lipoxygenase	MESH:D000171	11689(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Acrolein increases 5-lipoxygenase expression in murine macrophages through activation of ERK pathway .
1696540	0	Acrolein	0,8	CGRP	36,40	Acrolein	CGRP	MESH:D000171	24241(Tax:10116)	Chemical	Gene	depletes|nsubj|START_ENTITY depletes|dobj|END_ENTITY	Acrolein depletes the neuropeptides CGRP and substance P in sensory nerves in rat respiratory tract .
16036326	0	Acrolein	0,8	Hsp72	17,22	Acrolein	Hsp72	MESH:D000171	3303	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Acrolein induces Hsp72 via both PKCdelta/JNK and calcium signaling pathways in human umbilical vein endothelial cells .
11329622	0	Acrolein	0,8	epidermal_growth_factor_receptor	35,67	Acrolein	epidermal growth factor receptor	MESH:D000171	1956	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|nmod|END_ENTITY	Acrolein induces activation of the epidermal_growth_factor_receptor of human keratinocytes for cell death .
18048804	0	Acrolein	0,8	heme_oxygenase-1	17,33	Acrolein	heme oxygenase-1	MESH:D000171	3162	Chemical	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Acrolein induces heme_oxygenase-1 through PKC-delta and PI3K in human bronchial epithelial cells .
21385599	0	Acrylamide	0,10	cyclooxygenase-2	24,40	Acrylamide	cyclooxygenase-2	MESH:D020106	19225(Tax:10090)	Chemical	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|amod|END_ENTITY	Acrylamide up-regulates cyclooxygenase-2 expression through the MEK/ERK signaling pathway in mouse epidermal cells .
1603853	0	Acrylamide	0,10	glyceraldehyde-3-phosphate_dehydrogenase	44,84	Acrylamide	glyceraldehyde-3-phosphate dehydrogenase	MESH:D020106	2597	Chemical	Gene	quenching|amod|START_ENTITY quenching|nmod|fluorescence fluorescence|nmod|END_ENTITY	Acrylamide quenching of the fluorescence of glyceraldehyde-3-phosphate_dehydrogenase : reversible and irreversible effects .
26636733	0	Act_D	72,77	rpL3	19,23	Act D	rpL3	CHEBI:27666	27367(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|role role|nmod|END_ENTITY	Regulatory role of rpL3 in cell response to nucleolar stress induced by Act_D in tumor cells lacking functional p53 .
21089054	0	Acteoside	0,9	matrix_metalloproteinase-9	31,57	Acteoside	matrix metalloproteinase-9	MESH:C058956	4318	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Acteoside inhibits PMA-induced matrix_metalloproteinase-9 expression via CaMK/ERK - and JNK/NF-kB-dependent signaling .
20732961	0	Actinomycin_D	0,13	Mcl-1	24,29	Actinomycin D	Mcl-1	MESH:D003609	4170	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|compound|END_ENTITY	Actinomycin_D decreases Mcl-1 expression and acts synergistically with ABT-737 against small_cell_lung_cancer cell lines .
26047946	0	Activin_A	0,9	ACVR2A	44,50	Activin A	ACVR2A	null	92	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Activin_A inhibits BMP-signaling by binding ACVR2A and ACVR2B .
7624351	0	Activin_A	0,9	Pax-6	19,24	Activin A	Pax-6	null	395943(Tax:9031)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Activin_A inhibits Pax-6 expression and perturbs cell differentiation in the developing spinal cord in vitro .
14520001	0	Activin_A	0,9	Smad2	37,42	Activin A	Smad2	null	4087	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Activin_A induces phosphorylation of Smad2 but not complex formation of Smad2 with Smad4 in human colon_cancer cell line HT-29 .
15010888	0	Activin_A	0,9	TGF-beta1	48,57	Activin A	TGF-beta1	null	7040	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Activin_A inhibits growth-inhibitory signals by TGF-beta1 in differentiated human endometrial_adenocarcinoma cells .
10853708	0	Activin_A	0,9	insulin	21,28	Activin A	insulin	null	3630	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|compound|END_ENTITY	Activin_A stimulates insulin secretion in cultured human pancreatic islets .
22477338	0	Activin_A	0,9	interleukin_8	21,34	Activin A	interleukin 8	null	3576	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|amod|END_ENTITY	Activin_A stimulates interleukin_8 and vascular_endothelial_growth_factor release from cultured human endometrial stromal cells : possible implications for the pathogenesis of endometriosis .
10896109	0	Acyclic_amides	0,14	estrogen_receptor	18,35	Acyclic amides	estrogen receptor	null	2099	Chemical	Gene	START_ENTITY|nmod|ligands ligands|compound|END_ENTITY	Acyclic_amides as estrogen_receptor ligands : synthesis , binding , activity and receptor interaction .
20691089	0	Acyclovir	0,9	IDO	24,27	Acyclovir	IDO	MESH:D000212	3620	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Acyclovir inhibition of IDO to decrease Tregs as a glioblastoma treatment adjunct .
21859328	0	Acyclovir	0,9	breast_cancer_resistance_protein	39,71	Acyclovir	breast cancer resistance protein	MESH:D000212	9429	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Acyclovir is a substrate for the human breast_cancer_resistance_protein -LRB- BCRP/ABCG2 -RRB- : implications for renal tubular transport and acyclovir-induced nephrotoxicity .
13246635	0	Acyl	0,4	glyceraldehyde-3-phosphate_dehydrogenase	20,60	Acyl	glyceraldehyde-3-phosphate dehydrogenase	null	2597	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Acyl derivatives of glyceraldehyde-3-phosphate_dehydrogenase .
21440447	0	Acyl	0,4	hPRMT1	104,110	Acyl	hPRMT1	null	3276	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methyltransferase hPRMT1 .
11918834	0	Acyl	0,4	phospholipases_A2_and_C	20,43	Acyl	phospholipases A2 and C	null	151056	Chemical	Gene	specificity|amod|START_ENTITY specificity|nmod|END_ENTITY	Acyl specificity of phospholipases_A2_and_C in thrombin-stimulated human platelets .
5782352	0	Acyl_and_alk-1-enyl	0,19	alk-1	46,51	Acyl and alk-1-enyl	alk-1	null	11482(Tax:10090)	Chemical	Gene	compositions|amod|START_ENTITY compositions|nmod|END_ENTITY	Acyl_and_alk-1-enyl group compositions of the alk-1 ' - enyl_acyl and the diacyl_glycerophosphoryl_ethanolamines of mouse and ox brain .
18068983	0	Acylguanidine	0,13	beta-secretase	28,42	Acylguanidine	beta-secretase	null	23621	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Acylguanidine inhibitors of beta-secretase : optimization of the pyrrole ring substituents extending into the S1 ' substrate binding pocket .
18162398	0	Acylguanidine	0,13	beta-secretase	28,42	Acylguanidine	beta-secretase	null	23621	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Acylguanidine inhibitors of beta-secretase : optimization of the pyrrole ring substituents extending into the S1 and S3 substrate binding pockets .
6199745	0	Ad5-dihydrofolate	77,94	EIb	59,62	Ad5-dihydrofolate	EIb	null	282663(Tax:10090)	Chemical	Gene	region|nmod|START_ENTITY region|compound|END_ENTITY	Expression of dihydrofolate reductase , and of the adjacent EIb region , in an Ad5-dihydrofolate reductase recombinant virus .
16996734	0	Adamantane	0,10	11-beta-HSD-1	11,24	Adamantane	11-beta-HSD-1	MESH:D000218	15483(Tax:10090)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Adamantane 11-beta-HSD-1 inhibitors : Application of an isocyanide multicomponent reaction .
24900545	0	Adamantyl_Azaquinolone	21,43	JNK	44,47	Adamantyl Azaquinolone	JNK	null	116554(Tax:10116)	Chemical	Gene	Inhibitor|compound|START_ENTITY Inhibitor|compound|END_ENTITY	Identification of an Adamantyl_Azaquinolone JNK Selective Inhibitor .
26398439	0	Adapalene	0,9	cyclin-dependent_kinase_2	35,60	Adapalene	cyclin-dependent kinase 2	MESH:C063610	1017	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	Adapalene inhibits the activity of cyclin-dependent_kinase_2 in colorectal_carcinoma .
16289097	0	Adducin	24,31	RFX-1	0,5	Adducin	RFX-1	null	5989	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	RFX-1 , a putative alpha Adducin interacting protein in a human kidney library .
19836313	0	Adenine	0,7	MutY_homologue	70,84	Adenine	MutY homologue	MESH:D000225	4595	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Adenine removal activity and bacterial complementation with the human MutY_homologue -LRB- MUTYH -RRB- and Y165C , G382D , P391L and Q324R variants associated with colorectal_cancer .
25699637	0	Adenosine	116,125	A1	113,115	Adenosine	A1	MESH:D000241	597	Chemical	Gene	Agonists|compound|START_ENTITY Agonists|compound|END_ENTITY	5 ' - C-Ethyl-tetrazolyl-N -LRB- 6 -RRB- - Substituted Adenosine and 2-Chloro-adenosine Derivatives as Highly Potent Dual Acting A1 Adenosine Receptor Agonists and A3 Adenosine Receptor Antagonists .
12373740	0	Adenosine	0,9	A2A	10,13	Adenosine	A2A	MESH:D000241	64159(Tax:10116)	Chemical	Gene	antagonism|compound|START_ENTITY antagonism|compound|END_ENTITY	Adenosine A2A antagonism reverses levodopa-induced motor alterations in hemiparkinsonian rats .
22585137	0	Adenosine	0,9	A2A	10,13	Adenosine	A2A	MESH:D000241	28882	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|compound|END_ENTITY	Adenosine A2A antagonists in Parkinson 's _ disease : what 's next ?
7501252	0	Adenosine	0,9	A2A	10,13	Adenosine	A2A	MESH:D000241	64159(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Adenosine A2A receptors stimulate acetylcholine release from nerve terminals of the rat hippocampus .
26054642	0	Adenosine	0,9	A2AR	10,14	Adenosine	A2AR	MESH:D000241	135	Chemical	Gene	blockade|compound|START_ENTITY blockade|compound|END_ENTITY	Adenosine A2AR blockade prevents neuroinflammation-induced death of retinal_ganglion cells caused by elevated pressure .
14630725	0	Adenosine	0,9	A3_receptor	10,21	Adenosine	A3 receptor	MESH:D000241	11542(Tax:10090)	Chemical	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Adenosine A3_receptor activation modulates the capillary endothelial glycocalyx .
22278222	0	Adenosine	0,9	ADAR1	37,42	Adenosine	ADAR1	MESH:D000241	103	Chemical	Gene	deaminase|amod|START_ENTITY deaminase|appos|END_ENTITY	Adenosine deaminase acting on RNA 1 -LRB- ADAR1 -RRB- suppresses the induction of interferon by measles_virus .
25272020	0	Adenosine	0,9	ADAR1	37,42	Adenosine	ADAR1	MESH:D000241	103	Chemical	Gene	Acting|compound|START_ENTITY Acting|appos|END_ENTITY	Adenosine Deaminase Acting on RNA-1 -LRB- ADAR1 -RRB- Inhibits HIV-1 Replication in Human Alveolar Macrophages .
10413060	0	Adenosine	0,9	ANP	21,24	Adenosine	ANP	MESH:D000241	24602(Tax:10116)	Chemical	Gene	stimulates|amod|START_ENTITY END_ENTITY|nsubj|stimulates	Adenosine stimulates ANP expression in cultured ventricular cardiomyocytes .
25754047	0	Adenosine	8,17	Adenosine_Deaminase	44,63	Adenosine	Adenosine Deaminase	MESH:D000241	100	Chemical	Gene	Receptor|compound|START_ENTITY Colocalizes|nsubj|Receptor Colocalizes|nmod|END_ENTITY	The A2B Adenosine Receptor Colocalizes with Adenosine_Deaminase in Resting Parietal Cells from Gastric Mucosa .
17502665	0	Adenosine	0,9	CD39	34,38	Adenosine	CD39	MESH:D000241	12495(Tax:10090)	Chemical	Gene	generation|amod|START_ENTITY generation|acl|catalyzed catalyzed|nmod|END_ENTITY	Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression .
18838482	0	Adenosine	0,9	CD39	28,32	Adenosine	CD39	MESH:D000241	12495(Tax:10090)	Chemical	Gene	START_ENTITY|parataxis|mediators mediators|nsubj|END_ENTITY	Adenosine and inflammation : CD39 and CD73 are critical mediators in LPS-induced PMN trafficking into the lungs .
16823836	0	Adenosine	0,9	CXCR4	22,27	Adenosine	CXCR4	MESH:D000241	7852	Chemical	Gene	upregulates|amod|START_ENTITY END_ENTITY|nsubj|upregulates	Adenosine upregulates CXCR4 and enhances the proliferative and migratory responses of human carcinoma cells to CXCL12/SDF -1 alpha .
16611738	0	Adenosine	0,9	DPPIV	24,29	Adenosine	DPPIV	MESH:D000241	1803	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	Adenosine downregulates DPPIV on HT-29 colon_cancer cells by stimulating protein tyrosine phosphatase -LRB- s -RRB- and reducing ERK1/2 activity via a novel pathway .
16234312	0	Adenosine	0,9	ENaC	19,23	Adenosine	ENaC	MESH:D000241	24768(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Adenosine inhibits ENaC via cytochrome_P-450 epoxygenase-dependent metabolites of arachidonic_acid .
11805111	0	Adenosine	0,9	Hint	42,46	Adenosine	Hint	MESH:D000241	100009302(Tax:9986)	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Adenosine monophosphoramidase activity of Hint and Hnt1 supports function of Kin28 , Ccl1 , and Tfb3 .
8666814	0	Adenosine	0,9	IL-10	19,24	Adenosine	IL-10	MESH:D000241	3586	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|secretion secretion|compound|END_ENTITY	Adenosine enhances IL-10 secretion by human monocytes .
24907587	0	Adenosine	0,9	IL-1b	55,60	Adenosine	IL-1b	MESH:D000241	16176(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Adenosine through the A2A adenosine receptor increases IL-1b in the brain contributing to anxiety .
12202524	0	Adenosine	0,9	MMP-2	36,41	Adenosine	MMP-2	MESH:D000241	4313	Chemical	Gene	modulation|compound|START_ENTITY modulation|nmod|END_ENTITY	Adenosine A1 receptor modulation of MMP-2 secretion by trabecular meshwork cells .
16413516	0	Adenosine	0,9	NF-kappaB	37,46	Adenosine	NF-kappaB	MESH:D000241	4790	Chemical	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	Adenosine is a negative regulator of NF-kappaB and MAPK signaling in human intestinal epithelial cells .
14609736	0	Adenosine	0,9	S-adenosylhomocysteine_hydrolase	27,59	Adenosine	S-adenosylhomocysteine hydrolase	MESH:D000241	508158(Tax:9913)	Chemical	Gene	sites|amod|START_ENTITY sites|nmod|END_ENTITY	Adenosine binding sites at S-adenosylhomocysteine_hydrolase are controlled by the NAD + / NADH ratio of the enzyme .
24813734	0	Adenosine	0,9	S-adenosylhomocysteine_hydrolase	33,65	Adenosine	S-adenosylhomocysteine hydrolase	MESH:D000241	191	Chemical	Gene	START_ENTITY|dobj|inhibitors inhibitors|nmod|END_ENTITY	Adenosine analogue inhibitors of S-adenosylhomocysteine_hydrolase .
19846878	0	Adenosine	0,9	STAT1	54,59	Adenosine	STAT1	MESH:D000241	6772	Chemical	Gene	blocks|nsubj|START_ENTITY blocks|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Adenosine blocks IFN-gamma-induced phosphorylation of STAT1 on serine 727 to reduce macrophage activation .
9497488	0	Adenosine	0,9	TNF-alpha	43,52	Adenosine	TNF-alpha	MESH:D000241	24835(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|production production|amod|END_ENTITY	Adenosine decreases post-ischaemic cardiac TNF-alpha production : anti-inflammatory implications for preconditioning and transplantation .
9698510	0	Adenosine	0,9	TNF-alpha	26,35	Adenosine	TNF-alpha	MESH:D000241	7124	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|production production|amod|END_ENTITY	Adenosine reduces cardiac TNF-alpha production and human myocardial_injury following ischemia-reperfusion .
10444484	0	Adenosine	0,9	VEGF	22,26	Adenosine	VEGF	MESH:D000241	403802(Tax:9615)	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Adenosine upregulates VEGF expression in cultured myocardial vascular smooth muscle cells .
15967042	0	Adenosine	0,9	VEGF	46,50	Adenosine	VEGF	MESH:D000241	7422	Chemical	Gene	infusion|amod|START_ENTITY increases|nsubj|infusion increases|dobj|levels levels|nmod|END_ENTITY	Adenosine infusion increases plasma levels of VEGF in humans .
23069939	0	Adenosine	0,9	VEGF	34,38	Adenosine	VEGF	MESH:D000241	83785(Tax:10116)	Chemical	Gene	A|compound|START_ENTITY receptor-mediated|nsubj|A receptor-mediated|ccomp|promotes promotes|nsubj|induction induction|compound|END_ENTITY	Adenosine A -LRB- 2B -RRB- receptor-mediated VEGF induction promotes diabetic_glomerulopathy .
25966978	0	Adenosine	0,9	VEGF	59,63	Adenosine	VEGF	MESH:D000241	7422	Chemical	Gene	stimulates|compound|START_ENTITY angiogenesis|nsubj|stimulates angiogenesis|advcl|inducing inducing|dobj|END_ENTITY	Adenosine A2B receptor stimulates angiogenesis by inducing VEGF and eNOS in human microvascular endothelial cells .
7733232	0	Adenosine	0,9	adenosine_A1_receptor	53,74	Adenosine	adenosine A1 receptor	MESH:D000241	29290(Tax:10116)	Chemical	Gene	attenuates|amod|START_ENTITY attenuates|dep|role role|nmod|END_ENTITY	Adenosine attenuates calcium paradox injury : role of adenosine_A1_receptor .
11125033	0	Adenosine	0,9	adenosine_deaminase	84,103	Adenosine	adenosine deaminase	MESH:D000241	100756254	Chemical	Gene	receptors|compound|START_ENTITY behave|nsubj|receptors behave|nmod|protein protein|nmod|END_ENTITY	Adenosine A2B receptors behave as an alternative anchoring protein for cell surface adenosine_deaminase in lymphocytes and cultured cells .
25293641	0	Adenosine	0,9	adenosine_deaminase	57,76	Adenosine	adenosine deaminase	MESH:D000241	100	Chemical	Gene	START_ENTITY|nmod|co-immobilization co-immobilization|nmod|red red|amod|END_ENTITY	Adenosine reagent-free detection by co-immobilization of adenosine_deaminase and phenol red on an optical biostrip .
3991077	0	Adenosine	0,9	adenosine_deaminase	110,129	Adenosine	adenosine deaminase	MESH:D000241	24165(Tax:10116)	Chemical	Gene	sites|amod|START_ENTITY sites|dep|identification identification|acl|using using|nmod|END_ENTITY	Adenosine uptake sites in rat brain : identification using -LSB- 3H -RSB- nitrobenzylthioinosine and co-localization with adenosine_deaminase .
9144513	0	Adenosine	0,9	adenosine_deaminase	155,174	Adenosine	adenosine deaminase	MESH:D000241	100	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|dep|changes changes|nmod|pattern pattern|nmod|adenosine_kinase adenosine_kinase|nummod|END_ENTITY	Adenosine metabolism during phorbol_myristate_acetate-mediated induction of HL-60 cell differentiation : changes in expression pattern of adenosine_kinase , adenosine_deaminase , and 5 ' - nucleotidase .
2550786	0	Adenosine	0,9	adrenocorticotropic_hormone	35,62	Adenosine	adrenocorticotropic hormone	MESH:D000241	5443	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|release release|nmod|END_ENTITY	Adenosine regulates the release of adrenocorticotropic_hormone -LRB- ACTH -RRB- from cultured anterior pituitary cells .
7631858	0	Adenosine	0,9	atrial_natriuretic_peptide	36,62	Adenosine	atrial natriuretic peptide	MESH:D000241	100294648(Tax:9940)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|release release|compound|END_ENTITY	Adenosine modulates hypoxia-induced atrial_natriuretic_peptide release in fetal sheep .
8253116	0	Adenosine	0,9	atrial_natriuretic_peptide	34,60	Adenosine	atrial natriuretic peptide	MESH:D000241	24602(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|nmod|END_ENTITY	Adenosine inhibits the release of atrial_natriuretic_peptide from the perfused rat heart .
17065216	0	Adenosine	0,9	connexin_43	21,32	Adenosine	connexin 43	MESH:D000241	2697	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Adenosine stimulates connexin_43 expression and gap junctional communication in pituitary_folliculostellate_cells .
16468051	0	Adenosine	0,9	erythropoietin	78,92	Adenosine	erythropoietin	MESH:D000241	2056	Chemical	Gene	produced|nsubj|START_ENTITY produced|parataxis|has has|dobj|impact impact|nmod|production production|compound|END_ENTITY	Adenosine produced via the CD73/ecto -5 ' - nucleotidase pathway has no impact on erythropoietin production but is associated with reduced kidney weight .
8123156	0	Adenosine	0,9	erythropoietin	36,50	Adenosine	erythropoietin	MESH:D000241	2056	Chemical	Gene	modulation|compound|START_ENTITY modulation|nmod|secretion secretion|compound|END_ENTITY	Adenosine A2 receptor modulation of erythropoietin secretion in hepatocellular_carcinoma cells .
17301835	0	Adenosine	0,9	fibroblast_growth_factor-7	21,47	Adenosine	fibroblast growth factor-7	MESH:D000241	2252	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Adenosine stimulates fibroblast_growth_factor-7 gene expression via adenosine A2b receptor signaling in dermal papilla cells .
17920149	0	Adenosine	0,9	glial_cell_line-derived_neurotrophic_factor	32,75	Adenosine	glial cell line-derived neurotrophic factor	MESH:D000241	25453(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Adenosine induces expression of glial_cell_line-derived_neurotrophic_factor -LRB- GDNF -RRB- in primary rat astrocytes .
16682012	0	Adenosine	0,9	hypoxia-inducible_factor-1	70,96	Adenosine	hypoxia-inducible factor-1	MESH:D000241	3091	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	Adenosine modulates vascular_endothelial_growth_factor expression via hypoxia-inducible_factor-1 in human glioblastoma cells .
11562360	0	Adenosine	0,9	insect-derived_growth_factor	32,60	Adenosine	insect-derived growth factor	MESH:D000241	34978(Tax:7227)	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Adenosine deaminase activity of insect-derived_growth_factor is essential for its growth factor activity .
17705048	0	Adenosine	0,9	interleukin-6	51,64	Adenosine	interleukin-6	MESH:D000241	3569	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|secretion secretion|amod|END_ENTITY	Adenosine inhibition of lipopolysaccharide-induced interleukin-6 secretion by the osteoblastic cell line MG-63 .
9126707	0	Adenosine	0,9	interleukin_6	20,33	Adenosine	interleukin 6	MESH:D000241	24498(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|release release|amod|END_ENTITY	Adenosine increases interleukin_6 release and decreases tumour_necrosis_factor release from rat adrenal zona glomerulosa cells , ovarian cells , anterior pituitary cells , and peritoneal macrophages .
10510349	0	Adenosine	0,9	p27kip-1	120,128	Adenosine	p27kip-1	MESH:D000241	12576(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|induction induction|nmod|expression expression|amod|END_ENTITY	Adenosine inhibits macrophage colony-stimulating factor-dependent proliferation of macrophages through the induction of p27kip-1 expression .
22178888	0	Adenosine	0,9	p53	36,39	Adenosine	p53	MESH:D000241	7157	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|transcription transcription|compound|END_ENTITY	Adenosine promotes GATA-2-regulated p53 gene transcription to induce HepG2 cell apoptosis .
3130056	0	Adenosine	0,9	phospholipase_A	47,62	Adenosine	phospholipase A	MESH:D000241	57110	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	Adenosine inhibits phenylephrine activation of phospholipase_A in hamster brown adipocytes .
20592246	0	Adenosine	0,9	plasma_membrane_monoamine_transporter	23,60	Adenosine	plasma membrane monoamine transporter	MESH:D000241	222962	Chemical	Gene	transport|amod|START_ENTITY transport|nmod|END_ENTITY	Adenosine transport by plasma_membrane_monoamine_transporter : reinvestigation and comparison with organic cations .
2998734	0	Adenosine	0,9	prolactin	19,28	Adenosine	prolactin	MESH:D000241	24683(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|compound|END_ENTITY	Adenosine inhibits prolactin and growth_hormone secretion in a clonal pituitary cell line .
9636230	0	Adenosine	0,9	prolactin	55,64	Adenosine	prolactin	MESH:D000241	5617	Chemical	Gene	acts|nsubj|START_ENTITY acts|xcomp|stimulate stimulate|dobj|release release|nmod|END_ENTITY	Adenosine acts by A1 receptors to stimulate release of prolactin from anterior-pituitaries in vitro .
11000134	0	Adenosine	0,9	protein_tyrosine_phosphatase	54,82	Adenosine	protein tyrosine phosphatase	MESH:D000241	26191	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|activating activating|dobj|END_ENTITY	Adenosine induces endothelial apoptosis by activating protein_tyrosine_phosphatase : a possible role of p38alpha .
20057051	0	Adenosine	0,9	purine_nucleoside_phosphorylase	42,73	Adenosine	purine nucleoside phosphorylase	MESH:D000241	4860	Chemical	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	Adenosine binding to low-molecular-weight purine_nucleoside_phosphorylase : the structural basis for recognition based on its complex with the enzyme from Schistosoma_mansoni .
2064369	0	Adenosine	0,9	renin	36,41	Adenosine	renin	MESH:D000241	5972	Chemical	Gene	START_ENTITY|dep|brake brake|nmod|release release|compound|END_ENTITY	Adenosine : a physiological brake on renin release .
23302571	0	Adenosine	1,10	renin	100,105	Adenosine	renin	MESH:D000241	24715(Tax:10116)	Chemical	Gene	agonists|compound|START_ENTITY mitigated|nsubj|agonists mitigated|dobj|PAH PAH|nmod|rats rats|acl|induced induced|nmod|reduction reduction|nmod|levels levels|compound|END_ENTITY	-LSB- Adenosine receptors agonists mitigated PAH of rats induced by chronic hypoxia through reduction of renin activity/angiotensin _ II levels and increase of inducible nitric_oxide synthase-nitric_oxide levels -RSB- .
2570363	0	Adenosine	0,9	renin	19,24	Adenosine	renin	MESH:D000241	403838(Tax:9615)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|compound|END_ENTITY	Adenosine inhibits renin release induced by suprarenal-aortic constriction and prostacyclin .
19859827	0	Adenosine	0,9	thrombomodulin	20,34	Adenosine	thrombomodulin	MESH:D000241	7056	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Adenosine regulates thrombomodulin and endothelial_protein_C_receptor expression in folliculostellate cells of the pituitary gland .
21538184	0	Adenosine	0,9	toll-like_receptor_4	45,65	Adenosine	toll-like receptor 4	MESH:D000241	7099	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|nmod|END_ENTITY	Adenosine reduces cell surface expression of toll-like_receptor_4 and inflammation in response to lipopolysaccharide and matrix products .
21538184	0	Adenosine	0,9	toll-like_receptor_4	45,65	Adenosine	toll-like receptor 4	MESH:D000241	7099	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|nmod|END_ENTITY	Adenosine reduces cell surface expression of toll-like_receptor_4 and inflammation in response to lipopolysaccharide and matrix products .
12606947	0	Adenosine	0,9	tumor_necrosis_factor	80,101	Adenosine	tumor necrosis factor	MESH:D000241	7124	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|activation activation|nmod|factor-kappaB factor-kappaB|acl|induced induced|nmod|END_ENTITY	Adenosine suppresses activation of nuclear factor-kappaB selectively induced by tumor_necrosis_factor in different cell types .
16339914	0	Adenosine	0,9	tumor_necrosis_factor-alpha	19,46	Adenosine	tumor necrosis factor-alpha	MESH:D000241	21926(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|amod|END_ENTITY	Adenosine inhibits tumor_necrosis_factor-alpha release from mouse peritoneal macrophages via A2A and A2B but not the A3 adenosine receptor .
2166764	0	Adenosine	0,9	tumor_necrosis_factor-alpha	43,70	Adenosine	tumor necrosis factor-alpha	MESH:D000241	7124	Chemical	Gene	compounds|amod|START_ENTITY compounds|dep|inhibition inhibition|amod|END_ENTITY	Adenosine and related compounds counteract tumor_necrosis_factor-alpha inhibition of neutrophil migration : implication of a novel cyclic_AMP-independent action on the cell surface .
8326132	0	Adenosine	0,9	tumor_necrosis_factor-alpha	76,103	Adenosine	tumor necrosis factor-alpha	MESH:D000241	21926(Tax:10090)	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|production production|amod|END_ENTITY	Adenosine and a related carbocyclic nucleoside analogue selectively inhibit tumor_necrosis_factor-alpha production and protect mice against endotoxin challenge .
9440704	0	Adenosine	0,9	tumor_necrosis_factor-alpha	68,95	Adenosine	tumor necrosis factor-alpha	MESH:D000241	24835(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Adenosine inhibits lipopolysaccharide-induced cardiac expression of tumor_necrosis_factor-alpha .
9494021	0	Adenosine	0,9	tumor_necrosis_factor-alpha	59,86	Adenosine	tumor necrosis factor-alpha	MESH:D000241	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|nmod|END_ENTITY	Adenosine inhibits lipopolysaccharide-induced secretion of tumor_necrosis_factor-alpha in the failing human heart .
10521243	0	Adenosine	0,9	vascular_endothelial_growth_factor	38,72	Adenosine	vascular endothelial growth factor	MESH:D000241	7422	Chemical	Gene	activation|amod|START_ENTITY induces|nsubj|activation induces|dobj|END_ENTITY	Adenosine receptor activation induces vascular_endothelial_growth_factor in human retinal endothelial cells .
11303729	0	Adenosine	0,9	vascular_endothelial_growth_factor	30,64	Adenosine	vascular endothelial growth factor	MESH:D000241	7422	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|compound|END_ENTITY	Adenosine inhibits neutrophil vascular_endothelial_growth_factor release and transendothelial migration via A2B receptor activation .
16682012	0	Adenosine	0,9	vascular_endothelial_growth_factor	20,54	Adenosine	vascular endothelial growth factor	MESH:D000241	7422	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|compound|END_ENTITY	Adenosine modulates vascular_endothelial_growth_factor expression via hypoxia-inducible_factor-1 in human glioblastoma cells .
20067761	0	Adenosine	0,9	vascular_endothelial_growth_factor	23,57	Adenosine	vascular endothelial growth factor	MESH:D000241	7422	Chemical	Gene	up-regulates|amod|START_ENTITY END_ENTITY|nsubj|up-regulates	Adenosine up-regulates vascular_endothelial_growth_factor in human macrophages .
7945378	0	Adenosine	0,9	vascular_endothelial_growth_factor	64,98	Adenosine	vascular endothelial growth factor	MESH:D000241	7422	Chemical	Gene	START_ENTITY|nmod|induction induction|nmod|mRNA mRNA|compound|END_ENTITY	Adenosine as an endogenous mediator of hypoxia for induction of vascular_endothelial_growth_factor mRNA in U-937 cells .
8843903	0	Adenosine	0,9	vascular_endothelial_growth_factor	40,74	Adenosine	vascular endothelial growth factor	MESH:D000241	281572(Tax:9913)	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|dobj|induction induction|nmod|END_ENTITY	Adenosine mediates hypoxic induction of vascular_endothelial_growth_factor in retinal pericytes and endothelial cells .
25422142	0	Adenosine_Monophosphate	0,23	AMPK	42,46	Adenosine Monophosphate	AMPK	MESH:D000249	5563	Chemical	Gene	Kinase|compound|START_ENTITY Kinase|appos|END_ENTITY	Adenosine_Monophosphate Activated Kinase -LRB- AMPK -RRB- and its Key Role in Catabolism : Structure , Regulation , Biological Activity and Pharmacological Activation .
8765089	0	Adenosine_diphosphate	0,21	serotonin_transporter	35,56	Adenosine diphosphate	serotonin transporter	MESH:D000244	6532	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Adenosine_diphosphate inhibits the serotonin_transporter .
8165598	0	Adenosine_diphosphate	0,21	tissue-type_plasminogen_activator	60,93	Adenosine diphosphate	tissue-type plasminogen activator	MESH:D000244	25692(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|nmod|END_ENTITY	Adenosine_diphosphate stimulates the endothelial release of tissue-type_plasminogen_activator but not von_Willebrand factor from isolated-perfused rat hind limbs .
25721362	0	Adenosine_monophosphate	0,23	AMPK	50,54	Adenosine monophosphate	AMPK	MESH:D000249	5563	Chemical	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	Adenosine_monophosphate activated protein kinase -LRB- AMPK -RRB- , a mediator of estradiol-induced apoptosis in long-term estrogen deprived breast_cancer cells .
7516359	0	Adenosine_triphosphate	0,22	CCl4	59,63	Adenosine triphosphate	CCl4	MESH:D000255	116637(Tax:10116)	Chemical	Gene	protection|amod|START_ENTITY protection|nmod|END_ENTITY	Adenosine_triphosphate protection of chlordecone-amplified CCl4 hepatotoxicity and lethality .
24507034	0	Adenosine_triphosphate	0,22	CD4	54,57	Adenosine triphosphate	CD4	MESH:D000255	920	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Adenosine_triphosphate production by peripheral blood CD4 T cells in clinically stable renal transplant recipients .
23088987	0	Adenosine_triphosphate	0,22	P2Y2	31,35	Adenosine triphosphate	P2Y2	MESH:D000255	5029	Chemical	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Adenosine_triphosphate induced P2Y2 receptor activation induces proinflammatory cytokine release in uroepithelial cells .
20337886	0	Adenosine_triphosphate	0,22	RANKL	34,39	Adenosine triphosphate	RANKL	MESH:D000255	8600	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Adenosine_triphosphate stimulates RANKL expression through P2Y1_receptor-cyclo-oxygenase-dependent pathway in human periodontal ligament cells .
16006727	0	Adenosine_triphosphate	0,22	caspase-3	45,54	Adenosine triphosphate	caspase-3	MESH:D000255	836	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|nmod|END_ENTITY	Adenosine_triphosphate induces activation of caspase-3 in apoptosis of human granulosa-luteal cells .
16741039	0	Adenosine_triphosphate	0,22	endothelin-1	32,44	Adenosine triphosphate	endothelin-1	MESH:D000255	24323(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Adenosine_triphosphate inhibits endothelin-1 production by rat inner medullary collecting duct cells .
9140044	0	Adenylate	0,9	vasopressin	26,37	Adenylate	vasopressin	CHEBI:16027	396995(Tax:9823)	Chemical	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Adenylate cyclase-coupled vasopressin receptor activates AQP2 promoter via a dual effect on CRE and AP1 elements .
25600813	0	Adipocytokine	0,13	omentin	15,22	Adipocytokine	omentin	null	55600	Chemical	Gene	inhibits|advmod|START_ENTITY inhibits|nsubj|END_ENTITY	Adipocytokine , omentin inhibits doxorubicin-induced H9c2 cardiomyoblasts apoptosis through the inhibition of mitochondrial reactive oxygen species .
18207581	0	Adipocytokines	0,14	adiponectin	67,78	Adipocytokines	adiponectin	MESH:D054392	9370	Chemical	Gene	START_ENTITY|dep|Role Role|nmod|END_ENTITY	Adipocytokines in Down 's _ syndrome , an atheroma-free model : Role of adiponectin .
23270203	0	Adipocytokines	0,14	neuropeptide_Y	16,30	Adipocytokines	neuropeptide Y	MESH:D054392	4852	Chemical	Gene	START_ENTITY|appos|resistance resistance|compound|END_ENTITY	Adipocytokines , neuropeptide_Y and insulin resistance in overweight women with gynoid and android type of adipose tissue distribution .
16476877	0	Adipocytokines	0,14	plasminogen_activator_inhibitor_1	89,122	Adipocytokines	plasminogen activator inhibitor 1	MESH:D054392	5054	Chemical	Gene	START_ENTITY|dep|effect effect|nmod|END_ENTITY	Adipocytokines and incident diabetes_mellitus in older adults : the independent effect of plasminogen_activator_inhibitor_1 .
26848221	0	Adipokines	15,25	Insulin	27,34	Adipokines	Insulin	MESH:D054392	3630	Chemical	Gene	Resistance|compound|START_ENTITY Resistance|amod|END_ENTITY	Association of Adipokines , Insulin Resistance , Hypertension and Dyslipidemia in Patients with Psoriasis_Vulgaris .
18617073	0	Adipokines	0,10	insulin	12,19	Adipokines	insulin	MESH:D054392	3630	Chemical	Gene	START_ENTITY|appos|resistance resistance|compound|END_ENTITY	Adipokines , insulin resistance , and coronary_artery_calcification .
22854419	0	Adipokines	0,10	insulin	12,19	Adipokines	insulin	MESH:D054392	3630	Chemical	Gene	START_ENTITY|appos|resistance resistance|compound|END_ENTITY	Adipokines , insulin resistance and hyperandrogenemia in obese patients with polycystic_ovary_syndrome : cross-sectional correlations and the effects of weight_loss .
26713889	0	AdoMet	41,47	SET7/9	92,98	AdoMet	SET7/9	MESH:D012436	80854	Chemical	Gene	Recognition|compound|START_ENTITY Recognition|nmod|END_ENTITY	Sulfur-Oxygen Chalcogen Bonding Mediates AdoMet Recognition in the Lysine Methyltransferase SET7/9 .
10929058	0	Adrenaline	0,10	beta1_and_beta2_adrenergic_receptors	63,99	Adrenaline	beta1 and beta2 adrenergic receptors	MESH:D004837	15129(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Adrenaline inhibits macrophage nitric_oxide production through beta1_and_beta2_adrenergic_receptors .
10856891	0	Adrenaline	0,10	insulin	12,19	Adrenaline	insulin	MESH:D004837	105613195	Chemical	Gene	have|advmod|START_ENTITY have|nsubj|END_ENTITY	Adrenaline , insulin and glucagon do not have acute effects on plasma leptin levels in sheep : development and characterisation of an ovine leptin ELISA .
8662272	0	Adrenaline	0,10	insulin	100,107	Adrenaline	insulin	MESH:D004837	3630	Chemical	Gene	accompanied|dep|START_ENTITY accompanied|nmod|inhibition inhibition|nmod|secretion secretion|compound|END_ENTITY	Adrenaline - , not somatostatin-induced hyperpolarization is accompanied by a sustained inhibition of insulin secretion in INS-1 cells .
9326357	0	Adrenaline	0,10	insulin	104,111	Adrenaline	insulin	MESH:D004837	3630	Chemical	Gene	inhibits|advmod|START_ENTITY inhibits|nsubj|presence presence|dep|i i|nmod|cells cells|compound|END_ENTITY	Adrenaline inhibits depolarization-induced increases in capacitance the presence of elevated -LSB- Ca2 + -RSB- i in insulin secreting cells .
12538206	0	Adrenaline	0,10	macrophage_inflammatory_protein-1_alpha	47,86	Adrenaline	macrophage inflammatory protein-1 alpha	MESH:D004837	6348	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Adrenaline inhibits lipopolysaccharide-induced macrophage_inflammatory_protein-1_alpha in human monocytes : the role of beta-adrenergic receptors .
1311232	0	Adrenocorticotropin	0,19	interleukin-6	30,43	Adrenocorticotropin	interleukin-6	MESH:D000324	24498(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|release release|amod|END_ENTITY	Adrenocorticotropin increases interleukin-6 release from rat adrenal_zona_glomerulosa cells .
11403211	0	Adrenomedullin	0,14	CD11b	55,60	Adrenomedullin	CD11b	MESH:D053607	3684	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|upregulation upregulation|nmod|END_ENTITY	Adrenomedullin suppresses fMLP-induced upregulation of CD11b of human neutrophils .
16495482	0	Adrenomedullin	0,14	calcitonin-receptor-like_receptor	49,82	Adrenomedullin	calcitonin-receptor-like receptor	MESH:D053607	10203	Chemical	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	Adrenomedullin and CGRP interact with endogenous calcitonin-receptor-like_receptor in endothelial cells and induce its desensitisation by different mechanisms .
18401334	0	Adrenomedullin	0,14	connective_tissue_growth_factor	24,55	Adrenomedullin	connective tissue growth factor	MESH:D053607	64032(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Adrenomedullin inhibits connective_tissue_growth_factor expression , extracellular_signal-regulated_kinase activation and renal fibrosis .
15949644	0	Adrenomedullin	0,14	heme_oxygenase-1	23,39	Adrenomedullin	heme oxygenase-1	MESH:D053607	24451(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Adrenomedullin induces heme_oxygenase-1 gene expression and cGMP formation in rat vascular smooth muscle cells .
11488772	0	Adrenomedullin	0,14	neutral_endopeptidase	66,87	Adrenomedullin	neutral endopeptidase	MESH:D053607	4311	Chemical	Gene	START_ENTITY|dep|effect effect|nmod|inhibition inhibition|amod|END_ENTITY	Adrenomedullin -LRB- ADM -RRB- in the human forearm vascular bed : effect of neutral_endopeptidase inhibition and comparison with proadrenomedullin_NH2-terminal 20 peptide -LRB- PAMP -RRB- .
11159826	0	Adrenomedullin	0,14	proline-rich_tyrosine_kinase_2	26,56	Adrenomedullin	proline-rich tyrosine kinase 2	MESH:D053607	50646(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|xcomp|END_ENTITY	Adrenomedullin stimulates proline-rich_tyrosine_kinase_2 in vascular smooth muscle cells .
9149680	0	Adrenomedullin	0,14	renin	26,31	Adrenomedullin	renin	MESH:D053607	24715(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|compound|END_ENTITY	Adrenomedullin stimulates renin release and renin mRNA in mouse juxtaglomerular granular cells .
8735973	0	Adrenotensin	0,12	adrenomedullin	17,31	Adrenotensin	adrenomedullin	MESH:C094997	133	Chemical	Gene	START_ENTITY|dep|contracts contracts|amod|END_ENTITY	Adrenotensin : an adrenomedullin gene product contracts pulmonary blood vessels .
23760062	0	Adriamycin	76,86	Raf-1	119,124	Adriamycin	Raf-1	MESH:D004317	5894	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Upregulation of miR-195 increases the sensitivity of breast_cancer cells to Adriamycin treatment through inhibition of Raf-1 .
8913269	0	Adriamycin	0,10	c-jun	21,26	Adriamycin	c-jun	MESH:D004317	3725	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|kinase kinase|amod|END_ENTITY	Adriamycin activates c-jun N-terminal kinase in human leukemia cells : a relevance to apoptosis .
1283520	0	Adriamycin	0,10	granulocyte-macrophage_colony-stimulating_factor	68,116	Adriamycin	granulocyte-macrophage colony-stimulating factor	MESH:D004317	1437	Chemical	Gene	chemotherapy|compound|START_ENTITY chemotherapy|nmod|END_ENTITY	Adriamycin , bleomycin and vincristine chemotherapy with recombinant granulocyte-macrophage_colony-stimulating_factor in the treatment of AIDS-related Kaposi 's _ sarcoma .
8424669	0	Adriamycin	0,10	transferrin	31,42	Adriamycin	transferrin	MESH:D004317	7018	Chemical	Gene	START_ENTITY|dobj|conjugates conjugates|nmod|receptors receptors|amod|END_ENTITY	Adriamycin conjugates of human transferrin bind transferrin receptors and kill K562 and HL60 cells .
8424669	0	Adriamycin	0,10	transferrin	48,59	Adriamycin	transferrin	MESH:D004317	7018	Chemical	Gene	START_ENTITY|dobj|conjugates conjugates|nmod|receptors receptors|compound|END_ENTITY	Adriamycin conjugates of human transferrin bind transferrin receptors and kill K562 and HL60 cells .
9722497	0	Aeruginosin	0,11	thrombin	21,29	Aeruginosin	thrombin	null	2147	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Aeruginosin 103-A , a thrombin inhibitor from the cyanobacterium Microcystis viridis .
15358183	0	Afadin	0,6	ADIP	42,46	Afadin	ADIP	null	308023(Tax:10116)	Chemical	Gene	protein|amod|START_ENTITY END_ENTITY|nsubj|protein	Afadin - and alpha-actinin-binding protein ADIP directly binds beta ' - COP , a subunit of the coatomer complex .
24051929	0	Afatinib	0,8	EGFR	63,67	Afatinib	EGFR	MESH:C522924	1956	Chemical	Gene	START_ENTITY|nmod|therapy therapy|nmod|lung_adenocarcinoma lung_adenocarcinoma|amod|END_ENTITY	Afatinib , erlotinib and gefitinib in the first-line therapy of EGFR mutation-positive lung_adenocarcinoma : a review .
24439929	0	Afatinib	0,8	EGFR	138,142	Afatinib	EGFR	MESH:C522924	1956	Chemical	Gene	gemcitabine|compound|START_ENTITY gemcitabine|nmod|treatment treatment|nmod|patients patients|nmod|mutations mutations|compound|END_ENTITY	Afatinib versus cisplatin plus gemcitabine for first-line treatment of Asian patients with advanced non-small-cell_lung_cancer harbouring EGFR mutations -LRB- LUX-Lung 6 -RRB- : an open-label , randomised phase 3 trial .
24868099	0	Afatinib	18,26	EGFR	139,143	Afatinib	EGFR	MESH:C522924	1956	Chemical	Gene	study|nmod|START_ENTITY study|nmod|non-small_cell_lung_cancer non-small_cell_lung_cancer|acl|harboring harboring|dobj|END_ENTITY	Phase II study of Afatinib as third-line treatment for patients in Korea with stage IIIB/IV non-small_cell_lung_cancer harboring wild-type EGFR .
24929780	0	Afatinib	0,8	EGFR	29,33	Afatinib	EGFR	MESH:C522924	1956	Chemical	Gene	START_ENTITY|nmod|treatment treatment|nmod|NSCLC NSCLC|amod|END_ENTITY	Afatinib in the treatment of EGFR mutation-positive NSCLC -- a network meta-analysis .
25242668	0	Afatinib	41,49	EGFR	125,129	Afatinib	EGFR	MESH:C522924	1956	Chemical	Gene	Dual|dobj|START_ENTITY Dual|nmod|Inhibitors Inhibitors|compound|END_ENTITY	Activity of the EGFR-HER2 Dual Inhibitor Afatinib in EGFR-Mutant Lung Cancer Patients With Acquired Resistance to Reversible EGFR Tyrosine Kinase Inhibitors .
25247337	0	Afatinib	49,57	EGFR	95,99	Afatinib	EGFR	MESH:C522924	1956	Chemical	Gene	Efficacy|nmod|START_ENTITY Efficacy|nmod|Epidermal_Growth_Factor_Receptor Epidermal_Growth_Factor_Receptor|appos|END_ENTITY	Efficacy of the Irreversible ErbB Family Blocker Afatinib in Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- Tyrosine Kinase Inhibitor -LRB- TKI -RRB- - Pretreated Non-Small-Cell Lung Cancer Patients with Brain Metastases or Leptomeningeal_Disease .
25589191	0	Afatinib	0,8	EGFR	49,53	Afatinib	EGFR	MESH:C522924	1956	Chemical	Gene	START_ENTITY|dobj|chemotherapy chemotherapy|nmod|lung_adenocarcinoma lung_adenocarcinoma|amod|END_ENTITY	Afatinib versus cisplatin-based chemotherapy for EGFR mutation-positive lung_adenocarcinoma -LRB- LUX-Lung 3 and LUX-Lung 6 -RRB- : analysis of overall survival data from two randomised , phase 3 trials .
25714021	0	Afatinib	0,8	EGFR	94,98	Afatinib	EGFR	MESH:C522924	1956	Chemical	Gene	increases|nsubj|START_ENTITY increases|nmod|radiation radiation|nmod|cells cells|nmod|mutation mutation|amod|END_ENTITY	Afatinib increases sensitivity to radiation in non-small cell lung_cancer cells with acquired EGFR T790M mutation .
25862853	0	Afatinib	0,8	EGFR	80,84	Afatinib	EGFR	MESH:C522924	1956	Chemical	Gene	Effective|nsubj|START_ENTITY Effective|xcomp|Carrying Carrying|dobj|Deletion Deletion|compound|END_ENTITY	Afatinib is Especially Effective Against Non-small_Cell_Lung_Cancer Carrying an EGFR Exon 19 Deletion .
25933111	0	Afatinib	88,96	EGFR	149,153	Afatinib	EGFR	MESH:C522924	1956	Chemical	Gene	Cisplatin/Gemcitabine|compound|START_ENTITY Cisplatin/Gemcitabine|nmod|Patients Patients|nmod|Cancer Cancer|compound|END_ENTITY	Symptom and Quality of Life Improvement in LUX-Lung 6 : An Open-Label Phase III Study of Afatinib Versus Cisplatin/Gemcitabine in Asian Patients With EGFR Mutation-Positive Advanced Non-small-cell Lung Cancer .
25933111	0	Afatinib	88,96	EGFR	149,153	Afatinib	EGFR	MESH:C522924	1956	Chemical	Gene	Cisplatin/Gemcitabine|compound|START_ENTITY Cisplatin/Gemcitabine|nmod|Patients Patients|nmod|Cancer Cancer|compound|END_ENTITY	Symptom and Quality of Life Improvement in LUX-Lung 6 : An Open-Label Phase III Study of Afatinib Versus Cisplatin/Gemcitabine in Asian Patients With EGFR Mutation-Positive Advanced Non-small-cell Lung Cancer .
25956899	0	Afatinib	18,26	EGFR	139,143	Afatinib	EGFR	MESH:C522924	1956	Chemical	Gene	Study|nmod|START_ENTITY Study|nmod|END_ENTITY	Phase II Study of Afatinib as Third-Line Treatment for Patients in Korea With Stage IIIB/IV Non-Small_Cell_Lung_Cancer Harboring Wild-Type EGFR .
26094656	0	Afatinib	0,8	EGFR	125,129	Afatinib	EGFR	MESH:C522924	1956	Chemical	Gene	pemetrexed|nsubj|START_ENTITY pemetrexed|xcomp|harboring harboring|dobj|mutations mutations|compound|END_ENTITY	Afatinib versus cisplatin plus pemetrexed in Japanese patients with advanced non-small_cell_lung_cancer harboring activating EGFR mutations : Subgroup analysis of LUX-Lung 3 .
26206867	0	Afatinib	88,96	EGFR	0,4	Afatinib	EGFR	MESH:C522924	13649(Tax:10090)	Chemical	Gene	Sensitivity|nmod|START_ENTITY Predictors|nmod|Sensitivity Mutations|dep|Predictors Mutations|compound|END_ENTITY	EGFR Exon 18 Mutations in Lung Cancer : Molecular Predictors of Augmented Sensitivity to Afatinib or Neratinib as Compared with First - or Third-Generation TKIs .
26286086	0	Afatinib	118,126	EGFR	0,4	Afatinib	EGFR	MESH:C522924	1956	Chemical	Gene	Responsive|nmod|START_ENTITY Cancer|acl:relcl|Responsive Driver|nmod|Cancer Driver|nsubj|Duplication Duplication|compound|END_ENTITY	EGFR Kinase Domain Duplication -LRB- EGFR-KDD -RRB- Is a Novel Oncogenic Driver in Lung Cancer That Is Clinically Responsive to Afatinib .
26341921	0	Afatinib	0,8	EGFR	119,123	Afatinib	EGFR	MESH:C522924	13649(Tax:10090)	Chemical	Gene	Resistance|compound|START_ENTITY Resistance|nmod|Lung_Adenocarcinoma Lung_Adenocarcinoma|compound|END_ENTITY	Afatinib plus Cetuximab Delays Resistance Compared to Single-Agent Erlotinib or Afatinib in Mouse Models of TKI-Na ve EGFR L858R-Induced Lung_Adenocarcinoma .
26354527	0	Afatinib	0,8	EGFR	100,104	Afatinib	EGFR	MESH:C522924	1956	Chemical	Gene	START_ENTITY|nmod|Pretreated Pretreated|nmod|Inhibitors Inhibitors|compound|END_ENTITY	Afatinib in Non-Small_Cell_Lung_Cancer Harboring Uncommon EGFR Mutations Pretreated With Reversible EGFR Inhibitors .
26354527	0	Afatinib	0,8	EGFR	58,62	Afatinib	EGFR	MESH:C522924	1956	Chemical	Gene	START_ENTITY|nmod|Pretreated Pretreated|compound|END_ENTITY	Afatinib in Non-Small_Cell_Lung_Cancer Harboring Uncommon EGFR Mutations Pretreated With Reversible EGFR Inhibitors .
26668065	0	Afatinib	0,8	EGFR	26,30	Afatinib	EGFR	MESH:C522924	1956	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|compound|END_ENTITY	Afatinib , an Irreversible EGFR Family Inhibitor , Shows Activity Toward Pancreatic_Cancer Cells , Alone and in Combination with Radiotherapy , Independent of KRAS Status .
26891729	0	Afatinib	62,70	EGFR	17,21	Afatinib	EGFR	MESH:C522924	1956	Chemical	Gene	Diagnostic|nmod|START_ENTITY Kit|dep|Diagnostic Kit|compound|END_ENTITY	therascreen -LRB- -RRB- EGFR RGQ PCR Kit : A Companion Diagnostic for Afatinib and Gefitinib in Non-Small_Cell_Lung_Cancer .
27076973	0	Afatinib	0,8	EGFR	59,63	Afatinib	EGFR	MESH:C522924	1956	Chemical	Gene	START_ENTITY|nmod|setting setting|nmod|NSCLC NSCLC|acl|harbouring harbouring|dobj|mutations mutations|compound|END_ENTITY	Afatinib in first-line setting for NSCLC harbouring common EGFR mutations : new light after the preliminary results of LUX-Lung 7 ?
26532576	0	Afatinib	29,37	Egfr	124,128	Afatinib	Egfr	MESH:C522924	1956	Chemical	Gene	Gene|nmod|START_ENTITY Gene|nmod|END_ENTITY	Pharmacoeconomic Analysis Of Afatinib As 1st-Line Treatment Of Metastatic Non-Small_Cell_Lung_Cancer With Del19 Mutation Of Egfr Gene .
25247337	0	Afatinib	49,57	Epidermal_Growth_Factor_Receptor	61,93	Afatinib	Epidermal Growth Factor Receptor	MESH:C522924	1956	Chemical	Gene	Efficacy|nmod|START_ENTITY Efficacy|nmod|END_ENTITY	Efficacy of the Irreversible ErbB Family Blocker Afatinib in Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- Tyrosine Kinase Inhibitor -LRB- TKI -RRB- - Pretreated Non-Small-Cell Lung Cancer Patients with Brain Metastases or Leptomeningeal_Disease .
24761865	0	Aflatoxin_B1	0,12	H19	95,98	Aflatoxin B1	H19	MESH:D016604	283120	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Aflatoxin_B1 promotes cell growth and invasion in hepatocellular_carcinoma HepG2 cells through H19 and E2F1 .
25820822	0	Aflatoxin_B1	0,12	Src	21,24	Aflatoxin B1	Src	MESH:D016604	6714	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Aflatoxin_B1 induces Src phosphorylation and stimulates lung_cancer cell migration .
3141079	0	Aflatoxin_B1	0,12	cytochrome_P-450	108,124	Aflatoxin B1	cytochrome P-450	MESH:D016604	25251(Tax:10116)	Chemical	Gene	hydroxylation|amod|START_ENTITY microsomal|nsubj|hydroxylation microsomal|xcomp|END_ENTITY	Aflatoxin_B1 hydroxylation by the pregnenolone-16_alpha-carbonitrile-inducible form of rat liver microsomal cytochrome_P-450 .
8671718	0	Aflatoxin_B1	0,12	lacI	21,25	Aflatoxin B1	lacI	MESH:D016604	21788(Tax:10090)	Chemical	Gene	mutation|compound|START_ENTITY mutation|compound|END_ENTITY	Aflatoxin_B1 induced lacI mutation in liver and kidney of transgenic_mice C57BL/6N : effect of phorone .
10826104	0	Aflatoxins	0,10	prolactin	19,28	Aflatoxins	prolactin	MESH:D000348	24683(Tax:10116)	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|secretion secretion|compound|END_ENTITY	Aflatoxins inhibit prolactin secretion by rat pituitary cells in culture .
26661416	0	Ag	78,80	CO2	65,68	Ag	CO2	null	717	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of electrolyte composition on the electroreduction of CO2 to CO on Ag based gas diffusion electrodes .
24675437	0	Ag	89,91	SERS	110,114	Ag	SERS	null	54938	Chemical	Gene	nanoparticles|compound|START_ENTITY nanoparticles|nmod|END_ENTITY	Released plasmonic electric field of ultrathin tetrahedral-amorphous-carbon films coated Ag nanoparticles for SERS .
26601368	0	Ag	85,87	SERS	1,5	Ag	SERS	null	6301	Chemical	Gene	-RSB-|compound|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- SERS Enhancement Factor Analysis and Experiment of Carbon Nanotube Arrays Coated by Ag Nanoparticles -RSB- .
19233920	9	Ag	1400,1402	TAFI	1395,1399	Ag	t-PA	null	5327	Chemical	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Plasma TAFI Ag levels did not significantly change in patients with PHPT compared with the controls .
15634342	0	Ag-NPA-1	68,76	lipid_binding_protein	46,67	Ag-NPA-1	lipid binding protein	null	188761(Tax:6239)	Chemical	Gene	START_ENTITY|nsubj|analysis analysis|nmod|END_ENTITY	Conformational and functional analysis of the lipid_binding_protein Ag-NPA-1 from the parasitic nematode Ascaridia galli .
2338269	0	Agalactosyl_IgG	0,15	C-reactive_protein	64,82	Agalactosyl IgG	C-reactive protein	null	1401	Chemical	Gene	START_ENTITY|dep|correlation correlation|nmod|END_ENTITY	Agalactosyl_IgG in inflammatory_bowel_disease : correlation with C-reactive_protein .
26700816	0	Aggravate	49,58	FoxO1	15,20	Aggravate	FoxO1	null	56458(Tax:10090)	Chemical	Gene	Damage|compound|START_ENTITY END_ENTITY|nmod|Damage	TNF-a Inhibits FoxO1 by Up-regulating MiR-705 to Aggravate Oxidative Damage in Bone Marrow-Derived Mesenchymal Stem Cells during Osteoporosis .
21843531	0	Agmatine	0,8	ERK1/2	45,51	Agmatine	ERK1/2	MESH:D000376	5595;5594	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|expression expression|compound|END_ENTITY	Agmatine enhances neurogenesis by increasing ERK1/2 expression , and suppresses astrogenesis by decreasing BMP_2 ,4 and SMAD_1 ,5,8 expression in subventricular zone neural stem cells .
24465142	0	Agmatine	14,22	IL-1b	40,45	Agmatine	IL-1b	MESH:D000376	16176(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	The Effect of Agmatine on Expression of IL-1b and TLX Which Promotes Neuronal Differentiation in Lipopolysaccharide-Treated Neural Progenitors .
18825914	0	Agmatine	0,8	TNF-alpha	34,43	Agmatine	TNF-alpha	MESH:D000376	24835(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|amod|END_ENTITY	Agmatine inhibits hypoxia-induced TNF-alpha release from cultured retinal ganglion cells .
26775293	0	Agomelatine	0,11	BDNF	22,26	Agomelatine	BDNF	MESH:C084711	627	Chemical	Gene	Levels|compound|START_ENTITY Levels|compound|END_ENTITY	Agomelatine Increases BDNF Serum Levels in Depressed Patients in Correlation with the Improvement of Depressive Symptoms .
1444208	0	Agrimoniin	0,10	interleukin-1	68,81	Agrimoniin	interleukin-1	MESH:C052420	3552	Chemical	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Agrimoniin , an antitumor tannin of Agrimonia pilosa Ledeb. , induces interleukin-1 .
2804064	0	Ajoene	0,6	gastric_lipase	39,53	Ajoene	gastric lipase	MESH:C048980	8513	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|nmod|END_ENTITY	Ajoene prevents fat digestion by human gastric_lipase in vitro .
9986706	0	Ajoene	0,6	glutathione_reductase	57,78	Ajoene	glutathione reductase	MESH:C048980	2936	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Ajoene is an inhibitor and subversive substrate of human glutathione_reductase and Trypanosoma_cruzi trypanothione reductase : crystallographic , kinetic , and spectroscopic studies .
6146518	0	Ala-2-D-Trp-8-D-Cys-14-somatostatin	10,45	insulin	81,88	Ala-2-D-Trp-8-D-Cys-14-somatostatin	insulin	null	3630	Chemical	Gene	Effect|nmod|START_ENTITY induced|nsubj|Effect induced|dobj|release release|nmod|END_ENTITY	Effect of Ala-2-D-Trp-8-D-Cys-14-somatostatin on the arginine induced release of insulin , GH and glucagon in normal men .
20357718	0	Ala-9Val	45,53	Manganese_superoxide_dismutase	0,30	Ala-9Val	Manganese superoxide dismutase	null	6648	Chemical	Gene	gene|dep|START_ENTITY gene|amod|END_ENTITY	Manganese_superoxide_dismutase -LRB- MnSOD -RRB- gene -LRB- Ala-9Val , Ile58Thr -RRB- polymorphism in patients with age-related_macular_degeneration -LRB- AMD -RRB- .
9542720	0	Alacepril	0,9	angiotensin-converting_enzyme	14,43	Alacepril	angiotensin-converting enzyme	null	24310(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Alacepril , an angiotensin-converting_enzyme inhibitor , prevents cerebral_vasospasm in subarachnoid_hemorrhage model in rats .
8504118	0	Alamethicin	0,11	ATPase	75,81	Alamethicin	ATPase	MESH:D000408	1769	Chemical	Gene	START_ENTITY|dep|activity activity|amod|END_ENTITY	Alamethicin as a permeabilizing agent for measurements of Ca -LRB- 2 + -RRB- - dependent ATPase activity in proteoliposomes , sealed membrane vesicles , and whole cells .
15975903	0	Alanine	0,7	Arp1	20,24	Alanine	Arp1	CHEBI:16449	10121	Chemical	Gene	scanning|compound|START_ENTITY scanning|nmod|END_ENTITY	Alanine scanning of Arp1 delineates a putative binding site for Jnm1/dynamitin and Nip100/p150Glued .
17429060	0	Alanine	0,7	Insulin	96,103	Alanine	Insulin	CHEBI:16449	3630	Chemical	Gene	insulin|compound|START_ENTITY insulin|dep|Resistance Resistance|amod|END_ENTITY	Alanine aminotransferase and directly measured insulin sensitivity in a multiethnic cohort : the Insulin Resistance Atherosclerosis Study .
11193851	0	Alanine	0,7	VIP	20,23	Alanine	VIP	CHEBI:16449	7432	Chemical	Gene	scanning|compound|START_ENTITY scanning|nmod|END_ENTITY	Alanine scanning of VIP .
15166647	0	Alanine	0,7	aminopeptidase	8,22	Alanine	aminopeptidase	CHEBI:16449	10404	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Alanine aminopeptidase activity in urine : a new marker of chronic alcohol_abuse ?
21304212	0	Alanine	0,7	insulin	80,87	Alanine	insulin	CHEBI:16449	3630	Chemical	Gene	aminotransferase|amod|START_ENTITY associated|nsubjpass|aminotransferase associated|nmod|metabolic_syndrome metabolic_syndrome|nmod|resistance resistance|compound|END_ENTITY	Alanine aminotransferase is associated with metabolic_syndrome independently of insulin resistance .
23020992	0	Alanine	0,7	insulin	91,98	Alanine	insulin	CHEBI:16449	3630	Chemical	Gene	ratio|amod|START_ENTITY marker|nsubj|ratio marker|nmod|resistance resistance|compound|END_ENTITY	Alanine aminotransferase/aspartate _ aminotransferase ratio is the best surrogate marker for insulin resistance in non-obese Japanese adults .
9148904	0	Alanine	0,7	insulin	32,39	Alanine	insulin	CHEBI:16449	3630	Chemical	Gene	scanning|compound|START_ENTITY mutagenesis|nsubj|scanning mutagenesis|nmod|END_ENTITY	Alanine scanning mutagenesis of insulin .
25881570	0	Alantolactone	0,13	TNF-a	131,136	Alantolactone	TNF-a	MESH:C004363	7124	Chemical	Gene	START_ENTITY|nmod|Production Production|nmod|END_ENTITY	Alantolactone from Saussurea lappa Exerts Antiinflammatory Effects by Inhibiting Chemokine Production and STAT1 Phosphorylation in TNF-a and IFN-y-induced in HaCaT cells .
22940184	0	Alantolactone	0,13	inducible_nitric_oxide_synthase	25,56	Alantolactone	inducible nitric oxide synthase	MESH:C004363	18126(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Alantolactone suppresses inducible_nitric_oxide_synthase and cyclooxygenase-2 expression by down-regulating NF-kB , MAPK and AP-1 via the MyD88 signaling pathway in LPS-activated RAW 264.7 cells .
20367248	0	Albiglutide	0,11	GLP-1	19,24	Albiglutide	GLP-1	MESH:C534611	2641	Chemical	Gene	START_ENTITY|dep|analog analog|compound|END_ENTITY	Albiglutide : a new GLP-1 analog for the treatment of type 2 diabetes .
21887274	0	Albiglutide	0,11	glucagon-like_peptide-1	28,51	Albiglutide	glucagon-like peptide-1	MESH:C534611	24952(Tax:10116)	Chemical	Gene	START_ENTITY|appos|analog analog|amod|END_ENTITY	Albiglutide , a long lasting glucagon-like_peptide-1 analog , protects the rat heart against ischemia/reperfusion injury : evidence for improving cardiac metabolic efficiency .
12458679	0	Albugranin	0,10	granulocyte_colony_stimulating_factor	32,69	Albugranin	granulocyte colony stimulating factor	null	1440	Chemical	Gene	induces|advmod|START_ENTITY induces|nsubj|END_ENTITY	Albugranin , a recombinant human granulocyte_colony_stimulating_factor -LRB- G-CSF -RRB- genetically fused to recombinant human albumin induces prolonged myelopoietic effects in mice and monkeys .
26264240	0	Alcohol	8,15	53BP1	35,40	Alcohol	53BP1	D000431	7158	Chemical	Gene	Protein|compound|START_ENTITY Protein|nummod|END_ENTITY	Chronic Alcohol Exposure Decreases 53BP1 Protein Levels Leading to a Defective DNA Repair in Cultured Primary Cortical Neurons .
15456134	0	Alcohol	1,8	ADH1B	24,29	Alcohol	ADH1B	CHEBI:16236	125	Chemical	Gene	dehydrogenases|nsubj|START_ENTITY dehydrogenases|dobj|polymorphism polymorphism|compound|END_ENTITY	-LSB- Alcohol dehydrogenases ADH1B and ADH7 gene polymorphism in Russian population from the Siberian region -RSB- .
21284671	1	Alcohol	229,236	ADH1B	452,457	Alcohol	ADH1B	CHEBI:16236	125	Chemical	Gene	Pancreatitis|compound|START_ENTITY presented|nmod|Pancreatitis work|acl|presented account|nmod|work reports|nsubj|account generated|ccomp|reports generated|nmod|intake intake|acl:relcl|conferred conferred|nmod|END_ENTITY	This account of recent work presented at the 4th International Symposium on Alcohol Pancreatitis and Cirrhosis reports animal studies aimed at determining the role of the `` acetaldehyde burst , '' generated shortly upon ethanol intake , as the mechanism of protection against alcoholism conferred by the ADH1B * 2 polymorphism .
24303206	0	Alcohol	74,81	ADH1B	14,19	Alcohol	ADH1B	CHEBI:16236	125	Chemical	Gene	Consumption|compound|START_ENTITY Impact|nmod|Consumption Impact|nmod|Alleles Alleles|compound|END_ENTITY	The Impact of ADH1B Alleles and Educational Status on Levels and Modes of Alcohol Consumption in Russian Male Individuals .
24988262	0	Alcohol	0,7	ADH1B	54,59	Alcohol	ADH1B	CHEBI:16236	125	Chemical	Gene	consumption|compound|START_ENTITY mediates|nsubj|consumption mediates|dobj|relationship relationship|nmod|END_ENTITY	Alcohol consumption mediates the relationship between ADH1B and DSM-IV alcohol use disorder and criteria .
25410943	0	Alcohol	63,70	ADH1B	21,26	Alcohol	ADH1B	CHEBI:16236	125	Chemical	Gene	Phenotypes|compound|START_ENTITY Effects|nmod|Phenotypes Effects|nmod|Variants Variants|compound|END_ENTITY	The Joint Effects of ADH1B Variants and Childhood Adversity on Alcohol Related Phenotypes in African-American and European-American Women and Men .
26827895	0	Alcohol	0,7	ADH1B	67,72	Alcohol	ADH1B	D000431	125	Chemical	Gene	Drinking|compound|START_ENTITY Mediates|nsubj|Drinking Mediates|dobj|Association Association|nmod|Polymorphisms Polymorphisms|nmod|END_ENTITY	Alcohol Drinking Mediates the Association between Polymorphisms of ADH1B and ALDH2 and Hepatitis_B-Related_Hepatocellular_Carcinoma .
27087413	0	Alcohol	52,59	ADH1B	11,16	Alcohol	ADH1B	D000431	125	Chemical	Gene	Rates|compound|START_ENTITY Polymorphisms|nmod|Rates Polymorphisms|nsubj|Effects Effects|nmod|Genetic Genetic|compound|END_ENTITY	Effects of ADH1B and ALDH2 Genetic Polymorphisms on Alcohol Elimination Rates and Salivary Acetaldehyde Levels in Intoxicated Japanese Alcoholic Men .
26734614	0	Alcohol	16,23	ADH3	42,46	Alcohol	ADH3	D000431	126	Chemical	Gene	Predisposes|compound|START_ENTITY Predisposes|compound|END_ENTITY	Polymorphism of Alcohol Metabolizing Gene ADH3 Predisposes to Development of Alcoholic_Pancreatitis in North Indian Population .
24886599	0	Alcohol	0,7	ADHFE1	59,65	Alcohol	ADHFE1	CHEBI:16236	137872	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|proliferation proliferation|nmod|hypermethylation hypermethylation|nmod|END_ENTITY	Alcohol induces cell proliferation via hypermethylation of ADHFE1 in colorectal_cancer cells .
23087644	0	Alcohol	145,152	Brain-Derived_Neurotrophic_Factor	55,88	Alcohol	Brain-Derived Neurotrophic Factor	CHEBI:16236	627	Chemical	Gene	Individuals|compound|START_ENTITY Associations|nmod|Individuals Associations|nmod|Smoking Smoking|nmod|END_ENTITY	Associations of Cigarette Smoking and Polymorphisms in Brain-Derived_Neurotrophic_Factor and Catechol-O-Methyltransferase with Neurocognition in Alcohol Dependent Individuals during Early Abstinence .
24835642	0	Alcohol	160,167	Brain-Derived_Neurotrophic_Factor	30,63	Alcohol	Brain-Derived Neurotrophic Factor	CHEBI:16236	627	Chemical	Gene	Use|compound|START_ENTITY Living|nmod|Use People|acl|Living Therapy|nmod|People Responses|nmod|Therapy END_ENTITY|nmod|Responses	Beyond the Brain : The Role of Brain-Derived_Neurotrophic_Factor in Viroimmune Responses to Antiretroviral Therapy among People Living with HIV with and without Alcohol Use .
26893193	0	Alcohol	56,63	Brain-Derived_Neurotrophic_Factor	19,52	Alcohol	Brain-Derived Neurotrophic Factor	D000431	627	Chemical	Gene	Consumption|compound|START_ENTITY Role|nmod|Consumption Role|nmod|END_ENTITY	A Critical Role of Brain-Derived_Neurotrophic_Factor in Alcohol Consumption .
12551869	0	Alcohol	0,7	C-reactive_protein	48,66	Alcohol	C-reactive protein	CHEBI:16236	1401	Chemical	Gene	consumption|compound|START_ENTITY consumption|nmod|END_ENTITY	Alcohol consumption and plasma concentration of C-reactive_protein .
17034270	0	Alcohol	0,7	CAGE	39,43	Alcohol	CAGE	CHEBI:16236	168400	Chemical	Gene	use|nsubj|START_ENTITY use|nmod|END_ENTITY	Alcohol use in the elderly : beyond the CAGE .
17112310	0	Alcohol	0,7	CAGE	39,43	Alcohol	CAGE	CHEBI:16236	168400	Chemical	Gene	use|nsubj|START_ENTITY use|nmod|END_ENTITY	Alcohol use in the elderly : beyond the CAGE .
22100631	0	Alcohol	0,7	CYP2E1	41,47	Alcohol	CYP2E1	CHEBI:16236	1571	Chemical	Gene	intake|compound|START_ENTITY intake|nmod|END_ENTITY	Alcohol intake and folate antagonism via CYP2E1 and ALDH1 : effects on oral carcinogenesis .
18555008	0	Alcohol	0,7	FoxO1	23,28	Alcohol	FoxO1	CHEBI:16236	84482(Tax:10116)	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|END_ENTITY	Alcohol alters hepatic FoxO1 , p53 , and mitochondrial SIRT5 deacetylation function .
26087834	0	Alcohol	38,45	GABRA2	79,85	Alcohol	GABRA2	D000431	2555	Chemical	Gene	Responses|nmod|START_ENTITY Adaptation|nmod|Responses Affected|nsubjpass|Adaptation Affected|nmod|Interaction Interaction|nmod|Genotype Genotype|compound|END_ENTITY	Adaptation of Subjective Responses to Alcohol is Affected by an Interaction of GABRA2 Genotype and Recent Drinking .
10358198	0	Alcohol	0,7	IL-8	27,31	Alcohol	IL-8	CHEBI:16236	3576	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Alcohol -LRB- ethanol -RRB- inhibits IL-8 and TNF : role of the p38 pathway .
26493265	0	Alcohol	111,118	MEC	124,127	Alcohol	MEC	D000431	56477	Chemical	Gene	START_ENTITY|dep|Study Study|compound|END_ENTITY	Smoking and Risk of Breast_Cancer in a Racially/Ethnically Diverse Population of Mainly Women Who Do Not Drink Alcohol : The MEC Study .
18400453	0	Alcohol	0,7	MMP-2	16,21	Alcohol	MMP-2	CHEBI:16236	4313	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	Alcohol reduces MMP-2 in humans and isolated smooth muscle cells .
21357267	0	Alcohol	0,7	STAT3	115,120	Alcohol	STAT3	CHEBI:16236	20848(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|infection infection|nmod|enhancement enhancement|nmod|signaling signaling|compound|END_ENTITY	Alcohol suppresses the granulopoietic response to pulmonary Streptococcus_pneumoniae infection with enhancement of STAT3 signaling .
25427918	0	Alcohol	14,21	Sirt1	25,30	Alcohol	Sirt1	CHEBI:16236	23411	Chemical	Gene	START_ENTITY|nmod|Expression Expression|compound|END_ENTITY	The Effect of Alcohol on Sirt1 Expression and Function in Animal and Human Models of Hepatocellular_Carcinoma -LRB- HCC -RRB- .
19860807	0	Alcohol	0,7	TLR2	21,25	Alcohol	TLR2	CHEBI:16236	7097	Chemical	Gene	up-regulates|compound|START_ENTITY END_ENTITY|nsubj|up-regulates	Alcohol up-regulates TLR2 through a NO/cGMP dependent pathway .
12163104	0	Alcohol	0,7	TM3	29,32	Alcohol	TM3	CHEBI:16236	22003(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|apoptosis apoptosis|nmod|cells cells|nummod|END_ENTITY	Alcohol induces apoptosis in TM3 mouse Leydig cells via bax-dependent caspase-3 activation .
22841563	0	Alcohol	0,7	TNF-alpha	58,67	Alcohol	TNF-alpha	CHEBI:16236	7124	Chemical	Gene	depletes|nsubj|START_ENTITY depletes|dobj|coenzyme-Q coenzyme-Q|acl|associated associated|nmod|secretion secretion|amod|END_ENTITY	Alcohol depletes coenzyme-Q -LRB- 10 -RRB- associated with increased TNF-alpha secretion to induce cytotoxicity in HepG2 cells .
25333392	0	Alcohol	119,126	Task	72,76	Alcohol	Task	CHEBI:16236	29553(Tax:10116)	Chemical	Gene	Consumption|compound|START_ENTITY Abstinence|nmod|Consumption END_ENTITY|nmod|Abstinence	Impaired Response Inhibition in the Rat 5 Choice Continuous Performance Task during Protracted Abstinence from Chronic Alcohol Consumption .
26074326	0	Alcohol	0,7	Tax	82,85	Alcohol	Tax	D000431	6900	Chemical	Gene	Policies|compound|START_ENTITY Policies|dep|Effects Effects|nmod|Measures Measures|compound|END_ENTITY	Alcohol Price Policies as an Instrument of Health Equity : Differential Effects of Tax and Minimum Price Measures .
26094246	0	Alcohol	22,29	Tax	72,75	Alcohol	Tax	D000431	6900	Chemical	Gene	Taxes|compound|START_ENTITY Patterns|nmod|Taxes Produced|nsubj|Patterns Produced|nmod|Types Types|nmod|Study Study|compound|END_ENTITY	Assessing Patterns of Alcohol Taxes Produced by Various Types of Excise Tax Methods-A Simulation Study .
26719379	1	Alcohol	123,130	Tax	90,93	Alcohol	Tax	D000431	6900	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Product-Level Effects of a Specific Tax and a Minimum Unit Price for Alcohol .
19120068	0	Alcohol	0,7	Toll-like_receptor_2	33,53	Alcohol	Toll-like receptor 2	CHEBI:16236	7097	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	Alcohol functionally upregulates Toll-like_receptor_2 in airway epithelial cells .
25698630	0	Alcohol	110,117	Transferrin	50,61	Alcohol	Transferrin	CHEBI:16236	7018	Chemical	Gene	Consumption|compound|START_ENTITY END_ENTITY|nmod|Consumption	A Comparison Between Serum Carbohydrate-Deficient Transferrin and Hair Ethyl_Glucuronide in Detecting Chronic Alcohol Consumption in Routine .
26021975	0	Alcohol	142,149	Transferrin	82,93	Alcohol	Transferrin	D000431	7018	Chemical	Gene	Consumption|compound|START_ENTITY END_ENTITY|nmod|Consumption	Letter to the Editor Regarding ' A Comparison Between Serum Carbohydrate-Deficient Transferrin and Hair Ethyl_Glucuronide in Detecting Chronic Alcohol Consumption in Routine ' .
26021975	0	Alcohol	142,149	Transferrin	82,93	Alcohol	Transferrin	D000431	7018	Chemical	Gene	Consumption|compound|START_ENTITY END_ENTITY|nmod|Consumption	Letter to the Editor Regarding ' A Comparison Between Serum Carbohydrate-Deficient Transferrin and Hair Ethyl_Glucuronide in Detecting Chronic Alcohol Consumption in Routine ' .
26290909	0	Alcohol	156,163	Transferrin	96,107	Alcohol	Transferrin	D000431	7018	Chemical	Gene	Consumption|compound|START_ENTITY END_ENTITY|nmod|Consumption	Reply to Crunelle et al. about the Article A Comparison Between Serum Carbohydrate-Deficient Transferrin and Hair Ethyl_Glucuronide in Detecting Chronic Alcohol Consumption in Routine .
26290909	0	Alcohol	156,163	Transferrin	96,107	Alcohol	Transferrin	D000431	7018	Chemical	Gene	Consumption|compound|START_ENTITY END_ENTITY|nmod|Consumption	Reply to Crunelle et al. about the Article A Comparison Between Serum Carbohydrate-Deficient Transferrin and Hair Ethyl_Glucuronide in Detecting Chronic Alcohol Consumption in Routine .
26333807	0	Alcohol	17,24	Transferrin	33,44	Alcohol	Transferrin	D000431	7018	Chemical	Gene	Variant|compound|START_ENTITY Variant|compound|END_ENTITY	It Is Not Always Alcohol Abuse-A Transferrin Variant Impairing the CDT Test .
26380957	0	Alcohol	8,15	Tumor_Necrosis_Factor-Alpha	109,136	Alcohol	Tumor Necrosis Factor-Alpha	D000431	21926(Tax:10090)	Chemical	Gene	Lung_Injury|compound|START_ENTITY Lung_Injury|dep|Role Role|nmod|END_ENTITY	Chronic Alcohol Exposure Enhances Lipopolysaccharide-Induced Lung_Injury in Mice : Potential Role of Systemic Tumor_Necrosis_Factor-Alpha .
10794513	0	Alcohol	0,7	UDP-glucuronosyltransferase	21,48	Alcohol	UDP-glucuronosyltransferase	CHEBI:16236	24862(Tax:10116)	Chemical	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|amod|END_ENTITY	Alcohol up-regulates UDP-glucuronosyltransferase mRNA expression in rat liver and in primary rat hepatocyte culture .
17563066	0	Alcohol	0,7	alcohol_dehydrogenase	75,96	Alcohol	alcohol dehydrogenase	CHEBI:16236	10327	Chemical	Gene	consumption|compound|START_ENTITY consumption|dep|influence influence|nmod|variation variation|nmod|END_ENTITY	Alcohol consumption and type 2 diabetes : influence of genetic variation in alcohol_dehydrogenase .
20494945	0	Alcohol	0,7	alcohol_dehydrogenase	25,46	Alcohol	alcohol dehydrogenase	CHEBI:16236	10327	Chemical	Gene	habits|compound|START_ENTITY habits|appos|genotypes genotypes|compound|END_ENTITY	Alcohol drinking habits , alcohol_dehydrogenase genotypes and risk of acute_coronary_syndrome .
12188097	0	Alcohol	0,7	beta-endorphin	24,38	Alcohol	beta-endorphin	CHEBI:16236	5443	Chemical	Gene	urge|nsubj|START_ENTITY urge|dobj|change change|amod|END_ENTITY	Alcohol urge and plasma beta-endorphin change after alcohol challenge with naltrexone pretreatment in social drinkers .
12062480	0	Alcohol	0,7	c-Fos	31,36	Alcohol	c-Fos	CHEBI:16236	14281(Tax:10090)	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|expression expression|amod|END_ENTITY	Alcohol differentially affects c-Fos expression in the supraoptic nucleus of long-sleep and short-sleep mice .
7823175	0	Alcohol	0,7	c-fos	46,51	Alcohol	c-fos	CHEBI:16236	314322(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|amod|END_ENTITY	Alcohol selectively attenuates stress-induced c-fos expression in rat hippocampus .
12370848	0	Alcohol	0,7	c-myc	18,23	Alcohol	c-myc	CHEBI:16236	24577(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|mRNA mRNA|amod|END_ENTITY	Alcohol increases c-myc mRNA and protein in skeletal and cardiac muscle .
6724188	0	Alcohol	0,7	cytochrome_P-450	41,57	Alcohol	cytochrome P-450	CHEBI:16236	100328948(Tax:9986)	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|dep|role role|nmod|END_ENTITY	Alcohol metabolism and toxicity : role of cytochrome_P-450 .
1683858	0	Alcohol	0,7	gamma-glutamyl_transpeptidase	40,69	Alcohol	gamma-glutamyl transpeptidase	CHEBI:16236	92086	Chemical	Gene	START_ENTITY|dep|level level|amod|END_ENTITY	Alcohol , high_blood_pressure , and serum gamma-glutamyl_transpeptidase level .
8986195	0	Alcohol	0,7	gamma-glutamyl_transpeptidase	21,50	Alcohol	gamma-glutamyl transpeptidase	CHEBI:16236	92086	Chemical	Gene	consumption|compound|START_ENTITY consumption|appos|END_ENTITY	Alcohol consumption , gamma-glutamyl_transpeptidase -LRB- GGT -RRB- , and pulmonary function : a cross-sectional and longitudinal study in working men .
9555872	0	Alcohol	0,7	growth_hormone	74,88	Alcohol	growth hormone	CHEBI:16236	2688	Chemical	Gene	change|compound|START_ENTITY change|dep|association association|nmod|insulin-like_growth_factor-I insulin-like_growth_factor-I|amod|/ /|amod|END_ENTITY	Alcohol withdrawal-induced change in lipoprotein -LRB- a -RRB- : association with the growth_hormone / insulin-like_growth_factor-I -LRB- IGF-I -RRB- / IGF-binding_protein-1 -LRB- IGFBP-1 -RRB- axis .
16784954	0	Alcohol	0,7	heat_shock_protein	31,49	Alcohol	heat shock protein	CHEBI:16236	290549(Tax:10116)	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|expression expression|compound|END_ENTITY	Alcohol alters skeletal muscle heat_shock_protein gene expression in rats : these effects are moderated by sex , raised endogenous acetaldehyde , and starvation .
22320914	0	Alcohol	0,7	insulin	9,16	Alcohol	insulin	CHEBI:16236	3630	Chemical	Gene	START_ENTITY|appos|resistance resistance|compound|END_ENTITY	Alcohol , insulin resistance and the liver-brain_axis .
15830901	0	Alcohol	0,7	insulin-like_growth_factor-1	15,43	Alcohol	insulin-like growth factor-1	CHEBI:16236	24482(Tax:10116)	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|expression expression|amod|END_ENTITY	Alcohol alters insulin-like_growth_factor-1 activated oct_2 POU domain gene expression in the immature female hypothalamus .
14981261	0	Alcohol	0,7	luteinizing_hormone-releasing_hormone	17,54	Alcohol	luteinizing hormone-releasing hormone	CHEBI:16236	2796	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|amod|END_ENTITY	Alcohol inhibits luteinizing_hormone-releasing_hormone release by activating the endocannabinoid system .
3098959	0	Alcohol	0,7	luteinizing_hormone-releasing_hormone	19,56	Alcohol	luteinizing hormone-releasing hormone	CHEBI:16236	613033(Tax:9544)	Chemical	Gene	effects|compound|START_ENTITY effects|nmod|END_ENTITY	Alcohol effects on luteinizing_hormone-releasing_hormone stimulated luteinizing hormone and follicle-stimulating hormone in ovariectomized female rhesus_monkeys .
25421511	0	Alcohol	15,22	miR-21	92,98	Alcohol	miR-21	CHEBI:16236	406991	Chemical	Gene	Consumption|compound|START_ENTITY Consumption|nmod|END_ENTITY	Stress-Related Alcohol Consumption in Heavy Drinkers Correlates with Expression of miR-10a , miR-21 , and Components of the TAR-RNA-Binding Protein-Associated Complex .
3971900	0	Alcohol	0,7	neurotensin	38,49	Alcohol	neurotensin	CHEBI:16236	299757(Tax:10116)	Chemical	Gene	stimulation|compound|START_ENTITY stimulation|nmod|END_ENTITY	Alcohol and fatty_acid stimulation of neurotensin release from rat small intestine .
15830901	0	Alcohol	0,7	oct_2	54,59	Alcohol	oct 2	CHEBI:16236	117058(Tax:10116)	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|expression expression|amod|END_ENTITY	Alcohol alters insulin-like_growth_factor-1 activated oct_2 POU domain gene expression in the immature female hypothalamus .
3395466	0	Alcohol	0,7	prolactin	34,43	Alcohol	prolactin	CHEBI:16236	24683(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|compound|END_ENTITY	Alcohol inhibits suckling-induced prolactin release and milk yield .
26210390	0	Alcohol	0,7	protein_kinase_C_epsilon	46,70	Alcohol	protein kinase C epsilon	D000431	18754(Tax:10090)	Chemical	Gene	binding|nsubj|START_ENTITY binding|nmod|domain domain|nmod|END_ENTITY	Alcohol binding in the C1 -LRB- C1A + C1B -RRB- domain of protein_kinase_C_epsilon .
21816209	0	Alcohol	0,7	synaptotagmin_1	16,31	Alcohol	synaptotagmin 1	CHEBI:16236	20979(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Alcohol induces synaptotagmin_1 expression in neurons via activation of heat_shock factor 1 .
2648095	0	Alcohol	0,7	tumor_necrosis_factor	46,67	Alcohol	tumor necrosis factor	CHEBI:16236	7124	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|activity activity|compound|END_ENTITY	Alcohol suppresses lipopolysaccharide-induced tumor_necrosis_factor activity in serum and lung .
8651446	0	Alcohol	0,7	tumor_necrosis_factor-alpha	38,65	Alcohol	tumor necrosis factor-alpha	CHEBI:16236	24835(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Alcohol modulates alveolar macrophage tumor_necrosis_factor-alpha , superoxide anion , and nitric_oxide secretion in the rat .
8807202	0	Alcohol	0,7	tumor_necrosis_factor_alpha	44,71	Alcohol	tumor necrosis factor alpha	CHEBI:16236	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Alcohol inhibits lipopolysaccharide-induced tumor_necrosis_factor_alpha gene expression by peripheral blood mononuclear cells as measured by reverse transcriptase PCR in situ hybridization .
24405526	0	Aldehyde	0,8	ABCG2	148,153	Aldehyde	ABCG2	CHEBI:17478	9429	Chemical	Gene	dehydrogenase|amod|START_ENTITY isolate|nsubj|dehydrogenase isolate|advcl|selects selects|nsubj|function function|compound|END_ENTITY	Aldehyde dehydrogenase and ATP_binding_cassette_transporter_G2 -LRB- ABCG2 -RRB- functional assays isolate different populations of prostate stem cells where ABCG2 function selects for cells with increased stem cell activity .
24405526	0	Aldehyde	0,8	ABCG2	64,69	Aldehyde	ABCG2	CHEBI:17478	9429	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	Aldehyde dehydrogenase and ATP_binding_cassette_transporter_G2 -LRB- ABCG2 -RRB- functional assays isolate different populations of prostate stem cells where ABCG2 function selects for cells with increased stem cell activity .
24827824	0	Aldehyde	0,8	ALDH1	26,31	Aldehyde	ALDH1	CHEBI:17478	216	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	Aldehyde dehydrogenase 1 -LRB- ALDH1 -RRB- positivity correlates with poor prognosis in cervical_cancer .
25915760	0	Aldehyde	0,8	ALDH1	26,31	Aldehyde	ALDH1	D000079	216	Chemical	Gene	Dehydrogenase|compound|START_ENTITY Dehydrogenase|appos|END_ENTITY	Aldehyde Dehydrogenase 1 -LRB- ALDH1 -RRB- Is a Potential Marker for Cancer Stem Cells in Embryonal_Rhabdomyosarcoma .
25915760	0	Aldehyde	0,8	ALDH1	26,31	Aldehyde	ALDH1	D000079	216	Chemical	Gene	Dehydrogenase|compound|START_ENTITY Dehydrogenase|appos|END_ENTITY	Aldehyde Dehydrogenase 1 -LRB- ALDH1 -RRB- Is a Potential Marker for Cancer Stem Cells in Embryonal_Rhabdomyosarcoma .
26113217	0	Aldehyde	132,140	ALDH1A1	158,165	Aldehyde	ALDH1A1	D000079	216	Chemical	Gene	Dehydrogenase|compound|START_ENTITY Dehydrogenase|appos|END_ENTITY	A Novel Approach for Overcoming Drug Resistance in Breast_Cancer Chemotherapy by Targeting new Synthetic Curcumin Analogues Against Aldehyde Dehydrogenase 1 -LRB- ALDH1A1 -RRB- and Glycogen_Synthase_Kinase-3_b -LRB- GSK-3b -RRB- .
16131845	0	Aldehyde	0,8	ALDH2	107,112	Aldehyde	ALDH2	CHEBI:17478	217	Chemical	Gene	reduced|advmod|START_ENTITY reduced|nmod|vector vector|acl|coding coding|nmod|mRNA mRNA|compound|END_ENTITY	Aldehyde dehydrogenase -LRB- ALDH2 -RRB- activity in hepatoma cells is reduced by an adenoviral vector coding for an ALDH2 antisense mRNA .
16131845	0	Aldehyde	0,8	ALDH2	24,29	Aldehyde	ALDH2	CHEBI:17478	217	Chemical	Gene	reduced|advmod|START_ENTITY reduced|nsubjpass|activity activity|appos|END_ENTITY	Aldehyde dehydrogenase -LRB- ALDH2 -RRB- activity in hepatoma cells is reduced by an adenoviral vector coding for an ALDH2 antisense mRNA .
24771619	0	Aldehyde	0,8	Ald4p	24,29	Aldehyde	Ald4p	CHEBI:17478	854556(Tax:4932)	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	Aldehyde dehydrogenase , Ald4p , is a major component of mitochondrial fluorescent inclusion bodies in the yeast Saccharomyces_cerevisiae .
26851241	0	Aldehyde	69,77	CYP2A6	16,22	Aldehyde	CYP2A6	D000079	1548	Chemical	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of CYP2A6 by the Dietary Phenylpropanoid trans-Cinnamic Aldehyde -LRB- Cinnamaldehyde -RRB- and Estimation of Interactions with Nicotine and Letrozole .
26113217	0	Aldehyde	132,140	GSK-3b	201,207	Aldehyde	GSK-3b	D000079	2932	Chemical	Gene	Dehydrogenase|compound|START_ENTITY Dehydrogenase|appos|END_ENTITY	A Novel Approach for Overcoming Drug Resistance in Breast_Cancer Chemotherapy by Targeting new Synthetic Curcumin Analogues Against Aldehyde Dehydrogenase 1 -LRB- ALDH1A1 -RRB- and Glycogen_Synthase_Kinase-3_b -LRB- GSK-3b -RRB- .
25411835	0	Aldehyde	93,101	G_Protein-Coupled_Estrogen_Receptor-1	0,37	Aldehyde	G Protein-Coupled Estrogen Receptor-1	CHEBI:17478	171104(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Involved|nmod|Effect Involved|nsubjpass|END_ENTITY	G_Protein-Coupled_Estrogen_Receptor-1 Is Involved in the Protective Effect of Protocatechuic Aldehyde against Endothelial Dysfunction .
22654757	0	Aldose	51,57	AKR1B1	68,74	Aldose	AKR1B1	CHEBI:15693	231	Chemical	Gene	New|compound|START_ENTITY New|compound|END_ENTITY	The Prostaglandin_F Synthase Activity of the Human Aldose Reductase AKR1B1 Brings New Lenses to Look at Pathologic Conditions .
24474649	0	Aldose	0,6	p53	45,48	Aldose	p53	CHEBI:15693	22060(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Aldose reductase-mediated phosphorylation of p53 leads to mitochondrial_dysfunction and damage in diabetic platelets .
16109662	0	Aldosterone	0,11	11beta-hydroxysteroid_dehydrogenase_type_2	21,63	Aldosterone	11beta-hydroxysteroid dehydrogenase type 2	MESH:D000450	25117(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Aldosterone enhances 11beta-hydroxysteroid_dehydrogenase_type_2 expression in colonic epithelial cells in vivo .
6256713	0	Aldosterone	0,11	ACTH	34,38	Aldosterone	ACTH	MESH:D000450	5443	Chemical	Gene	START_ENTITY|nmod|infusion infusion|amod|END_ENTITY	Aldosterone response to prolonged ACTH infusion in juvenile hypertension .
20161115	0	Aldosterone	0,11	C-Reactive_Protein	48,66	Aldosterone	C-Reactive Protein	MESH:D000450	25419(Tax:10116)	Chemical	Gene	Antagonism|compound|START_ENTITY Reduces|nsubj|Antagonism Reduces|dobj|Excretion Excretion|compound|END_ENTITY	Aldosterone Receptor Antagonism Reduces Urinary C-Reactive_Protein Excretion in Angiotensin_II-Infused , Hypertensive Rats .
25109280	0	Aldosterone	0,11	C-reactive_protein	20,38	Aldosterone	C-reactive protein	MESH:D000450	25419(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Aldosterone induces C-reactive_protein expression via MR-ROS-MAPK-NF-kB signal pathway in rat vascular smooth muscle cells .
8770163	0	Aldosterone	0,11	CHIF	53,57	Aldosterone	CHIF	MESH:D000450	64190(Tax:10116)	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Aldosterone induction and epithelial distribution of CHIF .
17602195	0	Aldosterone	0,11	CTGF	20,24	Aldosterone	CTGF	MESH:D000450	1490	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Aldosterone induces CTGF in mesangial cells by activation of the glucocorticoid_receptor .
21239432	0	Aldosterone	0,11	CYP11B2	158,165	Aldosterone	CYP11B2	MESH:D000450	1585	Chemical	Gene	production|amod|START_ENTITY stimulated|nsubjpass|production stimulated|nmod|expression expression|nmod|aldosterone_synthase aldosterone_synthase|appos|END_ENTITY	Aldosterone production in human adrenocortical cells is stimulated by high-density_lipoprotein_2 -LRB- HDL2 -RRB- through increased expression of aldosterone_synthase -LRB- CYP11B2 -RRB- .
26540564	0	Aldosterone	148,159	CYP11B2	118,125	Aldosterone	CYP11B2	MESH:D000450	1585	Chemical	Gene	START_ENTITY|nsubj|Inhibitor Inhibitor|compound|END_ENTITY	Discovery of N - -LSB- 5 - -LRB- 6-chloro-3-cyano-1-methyl-1H-indol-2-yl -RRB- - pyridin-3-ylmethyl -RSB- - ethanesulfonamide , a Cortisol-Sparing CYP11B2 Inhibitor that Lowers Aldosterone in Human Subjects .
26763619	0	Aldosterone	21,32	CYP1A1	42,48	Aldosterone	CYP1A1	MESH:D000450	1543	Chemical	Gene	Polymorphism|compound|START_ENTITY Polymorphism|compound|END_ENTITY	Relationship Between Aldosterone Synthase CYP1A1 MspI Gene Polymorphism and Prostate Cancer Risk .
11249859	0	Aldosterone	0,11	ENaC	50,54	Aldosterone	ENaC	MESH:D000450	24768(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|translocation translocation|nmod|END_ENTITY	Aldosterone induces rapid apical translocation of ENaC in early portion of renal collecting system : possible role of SGK .
26340408	0	Aldosterone	64,75	KCNJ5	28,33	Aldosterone	KCNJ5	MESH:D000450	378557(Tax:8355)	Chemical	Gene	Release|compound|START_ENTITY Release|compound|END_ENTITY	Novel Insertion Mutation in KCNJ5 Channel Produces Constitutive Aldosterone Release From H295R Cells .
14610099	0	Aldosterone	0,11	NHE-1	22,27	Aldosterone	NHE-1	MESH:D000450	24782(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Aldosterone increases NHE-1 expression and induces NHE-1-dependent hypertrophy in neonatal rat ventricular myocytes .
12684793	0	Aldosterone	0,11	NHE3	45,49	Aldosterone	NHE3	MESH:D000450	24784(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|nmod|END_ENTITY	Aldosterone stimulates surface expression of NHE3 in renal proximal brush borders .
16543718	0	Aldosterone	0,11	NHE3	58,62	Aldosterone	NHE3	MESH:D000450	6550	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|nmod|END_ENTITY	Aldosterone stimulates activity and surface expression of NHE3 in human primary proximal tubule epithelial cells -LRB- RPTEC -RRB- .
18801914	0	Aldosterone	0,11	NHE3	84,88	Aldosterone	NHE3	MESH:D000450	6550	Chemical	Gene	regulation|amod|START_ENTITY involves|nsubj|regulation involves|ccomp|pump pump|nsubj|changes changes|nmod|+ +|compound|END_ENTITY	Aldosterone regulation of intestinal Na absorption involves SGK-mediated changes in NHE3 and Na + pump activity .
9530089	0	Aldosterone	0,11	NHE3	71,75	Aldosterone	NHE3	MESH:D000450	24784(Tax:10116)	Chemical	Gene	stimulates|amod|START_ENTITY intestinal|nsubj|stimulates intestinal|nmod|expression expression|compound|END_ENTITY	Aldosterone stimulates intestinal Na + absorption in rats by increasing NHE3 expression of the proximal colon .
24074711	0	Aldosterone	1,12	NOX4	50,54	Aldosterone	NOX4	MESH:D000450	85431(Tax:10116)	Chemical	Gene	antagonist|compound|START_ENTITY inhibits|nsubj|antagonist inhibits|dobj|expression expression|compound|END_ENTITY	-LSB- Aldosterone antagonist inhibits fibrosis-induced NOX4 protein expression in hepatic cells and tissues of rats -RSB- .
12668585	0	Aldosterone	0,11	Na-K-2Cl_cotransporter	26,48	Aldosterone	Na-K-2Cl cotransporter	MESH:D000450	83629(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Aldosterone regulates the Na-K-2Cl_cotransporter in vascular smooth muscle .
21803079	0	Aldosterone	0,11	PI3K	69,73	Aldosterone	PI3K	MESH:D000450	5293	Chemical	Gene	increases|nsubj|START_ENTITY increases|nmod|END_ENTITY	Aldosterone increases VEGF-A production in human neutrophils through PI3K , ERK1/2 and p38 pathways .
15356010	0	Aldosterone	0,11	Renin	15,20	Aldosterone	Renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|nmod|ratio ratio|amod|END_ENTITY	Aldosterone to Renin ratio in a primary care setting : the Bussolengo study .
24526370	0	Aldosterone	0,11	Renin	22,27	Aldosterone	Renin	MESH:D000450	5972	Chemical	Gene	active|amod|START_ENTITY ratio|amod|active ratio|compound|END_ENTITY	Aldosterone to active Renin ratio as screening test for primary_aldosteronism : reproducibility and influence of orthostasis and salt loading .
26883242	0	Aldosterone	4,15	Renin	16,21	Aldosterone	Renin	MESH:D000450	5972	Chemical	Gene	Ratio|compound|START_ENTITY Ratio|compound|END_ENTITY	The Aldosterone Renin Ratio -LRB- ARR -RRB- APP as Tool to Enhance the Detection Rate of Primary Aldosteronism .
11249859	0	Aldosterone	0,11	SGK	117,120	Aldosterone	SGK	MESH:D000450	29517(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|translocation translocation|dep|role role|nmod|END_ENTITY	Aldosterone induces rapid apical translocation of ENaC in early portion of renal collecting system : possible role of SGK .
19690383	0	Aldosterone	0,11	SGK1	89,93	Aldosterone	SGK1	MESH:D000450	399130(Tax:8355)	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway .
18268139	9	Aldosterone	1443,1454	TRPM7	1485,1490	Aldosterone	TRPM6	MESH:D000450	225997(Tax:10090)	Chemical	Gene	decreased|nsubj|START_ENTITY decreased|dobj|expression expression|nmod|END_ENTITY	Aldosterone decreased expression of renal TRPM7 and the downstream target annexin-1 -LRB- P < 0.05 -RRB- without effect on TRPM6 .
21803079	0	Aldosterone	0,11	VEGF-A	22,28	Aldosterone	VEGF-A	MESH:D000450	7422	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|production production|amod|END_ENTITY	Aldosterone increases VEGF-A production in human neutrophils through PI3K , ERK1/2 and p38 pathways .
12642011	0	Aldosterone	0,11	aldosterone_receptor	25,45	Aldosterone	aldosterone receptor	MESH:D000450	4306	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|compound|END_ENTITY	Aldosterone and specific aldosterone_receptor antagonists in hypertension and cardiovascular_disease .
21239432	0	Aldosterone	0,11	aldosterone_synthase	136,156	Aldosterone	aldosterone synthase	MESH:D000450	1585	Chemical	Gene	production|amod|START_ENTITY stimulated|nsubjpass|production stimulated|nmod|expression expression|nmod|END_ENTITY	Aldosterone production in human adrenocortical cells is stimulated by high-density_lipoprotein_2 -LRB- HDL2 -RRB- through increased expression of aldosterone_synthase -LRB- CYP11B2 -RRB- .
11447075	0	Aldosterone	0,11	angiotensin-converting-enzyme	20,49	Aldosterone	angiotensin-converting-enzyme	MESH:D000450	24310(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Aldosterone induces angiotensin-converting-enzyme gene expression in cultured neonatal rat cardiocytes .
12944039	0	Aldosterone	0,11	angiotensin-converting_enzyme	32,61	Aldosterone	angiotensin-converting enzyme	MESH:D000450	1636	Chemical	Gene	START_ENTITY|nmod|therapy therapy|amod|END_ENTITY	Aldosterone breakthrough during angiotensin-converting_enzyme inhibitor therapy .
10720583	0	Aldosterone	0,11	angiotensin_II	27,41	Aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	stimulation|amod|START_ENTITY stimulation|nmod|END_ENTITY	Aldosterone stimulation by angiotensin_II : influence of gender , plasma renin , and familial resemblance .
12072581	0	Aldosterone	0,11	angiotensin_II	36,50	Aldosterone	angiotensin II	MESH:D000450	24179(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|effect effect|nmod|END_ENTITY	Aldosterone modulates the effect of angiotensin_II on the electrical properties of rat heart .
12072581	6	Aldosterone	1350,1361	angiotensin_II	1382,1396	Aldosterone	angiotensin II	MESH:D000450	24179(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|effect effect|nmod|END_ENTITY	Aldosterone modulates effect of angiotensin_II on electrical properties of the heart .
12105134	0	Aldosterone	0,11	angiotensin_II	32,46	Aldosterone	angiotensin II	MESH:D000450	24179(Tax:10116)	Chemical	Gene	breakthrough|amod|START_ENTITY breakthrough|nmod|therapy therapy|amod|END_ENTITY	Aldosterone breakthrough during angiotensin_II receptor antagonist therapy in stroke-prone spontaneously hypertensive rats .
14581407	0	Aldosterone	0,11	angiotensin_II	86,100	Aldosterone	angiotensin II	MESH:D000450	11606(Tax:10090)	Chemical	Gene	plasminogen_activator_inhibitor-1|dep|START_ENTITY mediator|dep|plasminogen_activator_inhibitor-1 mediator|nmod|END_ENTITY	Aldosterone and not plasminogen_activator_inhibitor-1 is a critical mediator of early angiotensin_II / NG-nitro-L-arginine_methyl_ester-induced myocardial_injury .
1618554	0	Aldosterone	0,11	angiotensin_II	21,35	Aldosterone	angiotensin II	MESH:D000450	24179(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|receptor receptor|amod|END_ENTITY	Aldosterone enhances angiotensin_II receptor binding and inositol_phosphate responses .
17376762	0	Aldosterone	0,11	angiotensin_II	55,69	Aldosterone	angiotensin II	MESH:D000450	24179(Tax:10116)	Chemical	Gene	antagonism|amod|START_ENTITY exacerbates|nsubj|antagonism exacerbates|dobj|augmentation augmentation|compound|END_ENTITY	Aldosterone receptor antagonism exacerbates intrarenal angiotensin_II augmentation in ANG_II-dependent hypertension .
18308844	0	Aldosterone	0,11	angiotensin_II	55,69	Aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	breakthrough|amod|START_ENTITY breakthrough|acl|caused caused|nmod|blockage blockage|nmod|type type|amod|END_ENTITY	Aldosterone breakthrough caused by chronic blockage of angiotensin_II type 1 receptors in human adrenocortical cells : possible involvement of bone_morphogenetic_protein-6 actions .
188628	0	Aldosterone	0,11	angiotensin_II	83,97	Aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	production|amod|START_ENTITY production|dep|modulation modulation|nmod|sensitivity sensitivity|nmod|END_ENTITY	Aldosterone production by isolated glomerulosa cells : modulation of sensitivity to angiotensin_II and ACTH by extracellular potassium concentration .
22549242	0	Aldosterone	0,11	angiotensin_II	29,43	Aldosterone	angiotensin II	MESH:D000450	24179(Tax:10116)	Chemical	Gene	require|nsubj|START_ENTITY require|dobj|END_ENTITY	Aldosterone does not require angiotensin_II to activate NCC through a WNK4-SPAK-dependent pathway .
3035282	0	Aldosterone	0,11	angiotensin_II	90,104	Aldosterone	angiotensin II	MESH:D000450	24179(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY production|dep|responsiveness responsiveness|nmod|END_ENTITY	Aldosterone production after short-term culture of rat adrenal capsule : responsiveness to angiotensin_II , potassium and ACTH .
6255971	0	Aldosterone	1,12	angiotensin_II	36,50	Aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	production|compound|START_ENTITY production|acl|vitro vitro|nmod|END_ENTITY	-LSB- Aldosterone production in vitro by angiotensin_II : the role of Ca + + -RSB- .
7047005	0	Aldosterone	0,11	angiotensin_II	30,44	Aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	responsiveness|nsubj|START_ENTITY responsiveness|xcomp|END_ENTITY	Aldosterone responsiveness to angiotensin_II after sodium restriction in subjects with low renin essential hypertension .
870773	0	Aldosterone	0,11	angiotensin_II	84,98	Aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	regulation|amod|START_ENTITY regulation|dep|responsiveness responsiveness|nmod|END_ENTITY	Aldosterone regulation in essential hypertension : altered adrenal responsiveness to angiotensin_II .
18654024	0	Aldosterone	0,11	angiotensin_converting_enzyme	45,74	Aldosterone	angiotensin converting enzyme	MESH:D000450	24310(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|xcomp|END_ENTITY	Aldosterone , but not angiotensin_II , reduces angiotensin_converting_enzyme 2 gene expression levels in cultured neonatal rat cardiomyocytes .
2968054	0	Aldosterone	0,11	atrial_natriuretic_factor	60,85	Aldosterone	atrial natriuretic factor	MESH:D000450	24602(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|levels levels|nmod|END_ENTITY	Aldosterone and renin inhibition by physiological levels of atrial_natriuretic_factor .
18566129	0	Aldosterone	0,11	cardiotrophin-1	20,35	Aldosterone	cardiotrophin-1	MESH:D000450	13019(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Aldosterone induces cardiotrophin-1 expression in HL-1 adult cardiomyocytes .
6794622	0	Aldosterone	0,11	citrate_synthase	55,71	Aldosterone	citrate synthase	MESH:D000450	1431	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|ccomp|transport transport|advcl|affecting affecting|dobj|activity activity|amod|END_ENTITY	Aldosterone stimulates Na + transport without affecting citrate_synthase activity in cultured cells .
15608389	0	Aldosterone	0,11	connective_tissue_growth_factor	24,55	Aldosterone	connective tissue growth factor	MESH:D000450	64032(Tax:10116)	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	Aldosterone upregulates connective_tissue_growth_factor gene expression via p38 MAPK pathway and mineralocorticoid receptor in ventricular myocytes .
18660453	0	Aldosterone	0,11	endothelin-1	43,55	Aldosterone	endothelin-1	MESH:D000450	24323(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|xcomp|interleukin-18 interleukin-18|nmod|END_ENTITY	Aldosterone induces interleukin-18 through endothelin-1 , angiotensin_II , Rho/Rho-kinase , and PPARs in cardiomyocytes .
19638349	0	Aldosterone	0,11	endothelin-1	54,66	Aldosterone	endothelin-1	MESH:D000450	24323(Tax:10116)	Chemical	Gene	modulates|amod|START_ENTITY steroid|nsubj|modulates steroid|nmod|gene gene|amod|END_ENTITY	Aldosterone modulates steroid receptor binding to the endothelin-1 gene -LRB- edn1 -RRB- .
26775567	0	Aldosterone	0,11	endothelin-1	57,69	Aldosterone	endothelin-1	MESH:D000450	13614(Tax:10090)	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|structure structure|nmod|gene gene|amod|END_ENTITY	Aldosterone alters the chromatin structure of the murine endothelin-1 gene .
11880328	0	Aldosterone	0,11	epidermal_growth_factor_receptor	29,61	Aldosterone	epidermal growth factor receptor	MESH:D000450	404306(Tax:9615)	Chemical	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	Aldosterone interaction with epidermal_growth_factor_receptor signaling in MDCK cells .
12939263	0	Aldosterone	0,11	epidermal_growth_factor_receptor	23,55	Aldosterone	epidermal growth factor receptor	MESH:D000450	1956	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	Aldosterone stimulates epidermal_growth_factor_receptor expression .
22016493	0	Aldosterone	0,11	epidermal_growth_factor_receptor	83,115	Aldosterone	epidermal growth factor receptor	MESH:D000450	24329(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|exchanger exchanger|nmod|transactivation transactivation|nmod|END_ENTITY	Aldosterone stimulates the cardiac Na -LRB- + -RRB- / H -LRB- + -RRB- exchanger via transactivation of the epidermal_growth_factor_receptor .
17602195	0	Aldosterone	0,11	glucocorticoid_receptor	65,88	Aldosterone	glucocorticoid receptor	MESH:D000450	2908	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Aldosterone induces CTGF in mesangial cells by activation of the glucocorticoid_receptor .
26287126	0	Aldosterone	0,11	glucocorticoid_receptor	50,73	Aldosterone	glucocorticoid receptor	MESH:D000450	2908	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Aldosterone induces clonal b-cell failure through glucocorticoid_receptor .
18660453	0	Aldosterone	0,11	interleukin-18	20,34	Aldosterone	interleukin-18	MESH:D000450	29197(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Aldosterone induces interleukin-18 through endothelin-1 , angiotensin_II , Rho/Rho-kinase , and PPARs in cardiomyocytes .
24512358	0	Aldosterone	0,11	nrf2	43,47	Aldosterone	nrf2	MESH:D000450	4780	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Aldosterone activates transcription factor nrf2 in kidney cells both in vitro and in vivo .
15699470	0	Aldosterone	0,11	p38MAP_kinase	31,44	Aldosterone	p38MAP kinase	MESH:D000450	81649(Tax:10116)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Aldosterone activates vascular p38MAP_kinase and NADPH oxidase via c-Src .
15921847	0	Aldosterone	0,11	plasminogen_activator_inhibitor-1	22,55	Aldosterone	plasminogen activator inhibitor-1	MESH:D000450	24617(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|synthesis synthesis|amod|END_ENTITY	Aldosterone increases plasminogen_activator_inhibitor-1 synthesis in rat cardiomyocytes .
16461185	0	Aldosterone	0,11	renin	81,86	Aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|nmod|hypertension hypertension|compound|END_ENTITY	Aldosterone and left_ventricular_hypertrophy in Afro-Caribbean subjects with low renin hypertension .
20225167	0	Aldosterone	0,11	renin	15,20	Aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|nmod|ratio ratio|compound|END_ENTITY	Aldosterone to renin ratio -- a reliable screening tool for primary_aldosteronism ?
22024666	0	Aldosterone	0,11	renin	29,34	Aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|dep|associations associations|amod|END_ENTITY	Aldosterone and aldosterone : renin ratio associations with insulin resistance and blood pressure in African Americans .
24666971	0	Aldosterone	0,11	renin	22,27	Aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|nmod|ratio ratio|compound|END_ENTITY	Aldosterone to active renin ratio is associated with nocturnal blood pressure in obese and treated hypertensive patients : the Styrian Hypertension Study .
6132734	0	Aldosterone	0,11	renin	24,29	Aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|nmod|depletion depletion|compound|END_ENTITY	Aldosterone response to renin , angiotensin , ACTH , hemorrhage and sodium depletion in a freshwater teleost , Catostomus macrocheilus .
6397501	0	Aldosterone	0,11	renin	23,28	Aldosterone	renin	MESH:D000450	24715(Tax:10116)	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Aldosterone and plasma renin activity in hyperthyroid rats : effects of propranolol and propylthiouracil .
7047005	0	Aldosterone	0,11	renin	91,96	Aldosterone	renin	MESH:D000450	5972	Chemical	Gene	responsiveness|nsubj|START_ENTITY responsiveness|xcomp|angiotensin_II angiotensin_II|nmod|subjects subjects|nmod|hypertension hypertension|amod|END_ENTITY	Aldosterone responsiveness to angiotensin_II after sodium restriction in subjects with low renin essential hypertension .
705230	0	Aldosterone	0,11	renin	59,64	Aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|nmod|relationship relationship|nmod|activity activity|compound|END_ENTITY	Aldosterone in primary hypertension relationship to plasma renin activity and urinary electrolytes and a comparison with normotensive subjects .
24654783	0	Aldosterone	0,11	striatin	56,64	Aldosterone	striatin	MESH:D000450	6801	Chemical	Gene	effects|nmod:poss|START_ENTITY mediated|nsubjpass|effects mediated|nmod|END_ENTITY	Aldosterone 's rapid , nongenomic effects are mediated by striatin : a modulator of aldosterone 's effect on estrogen action .
23838006	0	Aldosterone	0,11	transient_receptor_potential_melastatin_7_cation_channel	30,86	Aldosterone	transient receptor potential melastatin 7 cation channel	MESH:D000450	54822	Chemical	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Aldosterone signaling through transient_receptor_potential_melastatin_7_cation_channel -LRB- TRPM7 -RRB- and its a-kinase domain .
23838006	0	Aldosterone	0,11	transient_receptor_potential_melastatin_7_cation_channel	30,86	Aldosterone	transient receptor potential melastatin 7 cation channel	MESH:D000450	54822	Chemical	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Aldosterone signaling through transient_receptor_potential_melastatin_7_cation_channel -LRB- TRPM7 -RRB- and its a-kinase domain .
25652176	0	Alectinib	0,9	ALK	40,43	Alectinib	ALK	null	238	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Alectinib : a selective , next-generation ALK inhibitor for treatment of ALK-rearranged non-small-cell_lung_cancer .
26579422	0	Alectinib	0,9	ALK	65,68	Alectinib	ALK	MESH:C582670	238	Chemical	Gene	START_ENTITY|parataxis|inhibitor inhibitor|nsubj|kinase kinase|appos|END_ENTITY	Alectinib : a novel second generation anaplastic_lymphoma kinase -LRB- ALK -RRB- inhibitor for overcoming clinically-acquired resistance .
26739884	0	Alectinib	0,9	ALK	23,26	Alectinib	ALK	MESH:C582670	238	Chemical	Gene	Approved|compound|START_ENTITY Approved|nmod|NSCLC NSCLC|compound|END_ENTITY	Alectinib Approved for ALK + NSCLC .
27091190	0	Alectinib	86,95	ALK	9,12	Alectinib	ALK	MESH:C582670	238	Chemical	Gene	Resistance|nmod|START_ENTITY Resistance|nsubj|Confers Confers|compound|END_ENTITY	Acquired ALK L1152R Mutation Confers Resistance to Ceritinib and Predicts Response to Alectinib .
15490268	0	Alendronate	0,11	TNFalpha	26,34	Alendronate	TNFalpha	MESH:D019386	7124	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	Alendronate reduces serum TNFalpha and IL-1beta , increases neutrophil counts , and improves bone_mineral_density and bone metabolism indices in patients with chronic_idiopathic_neutropenia -LRB- CIN -RRB- - associated osteopenia/osteoporosis .
19834579	0	Alendronate	0,11	VEGF	21,25	Alendronate	VEGF	MESH:D019386	22339(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Alendronate inhibits VEGF expression in growth plate chondrocytes by acting on the mevalonate pathway .
11127199	0	Alendronate	0,11	collagenase_3	23,36	Alendronate	collagenase 3	MESH:D019386	171052(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Alendronate stimulates collagenase_3 expression in osteoblasts by posttranscriptional mechanisms .
14619641	0	Alendronate	0,11	gonadotropin-releasing_hormone	59,89	Alendronate	gonadotropin-releasing hormone	MESH:D019386	2796	Chemical	Gene	START_ENTITY|nmod|therapy therapy|amod|END_ENTITY	Alendronate for the prevention of bone mineral loss during gonadotropin-releasing_hormone agonist therapy .
12522661	0	Alendronate	0,11	interleukin_6	43,56	Alendronate	interleukin 6	MESH:D019386	3569	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	Alendronate and etidronate do not regulate interleukin_6 and 11 synthesis in normal human osteoblasts in culture .
21752290	0	Alendronate	0,11	osteoprotegerin	32,47	Alendronate	osteoprotegerin	MESH:D019386	25341(Tax:10116)	Chemical	Gene	START_ENTITY|acl|combined combined|nmod|END_ENTITY	Alendronate -LRB- ALN -RRB- combined with osteoprotegerin -LRB- OPG -RRB- significantly improves mechanical properties of long bone than the single use of ALN or OPG in the ovariectomized rats .
26351115	0	Alendronate	0,11	osteoprotegerin	23,38	Alendronate	osteoprotegerin	MESH:D019386	4982	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	Alendronate stimulates osteoprotegerin expression in fibroblasts from periprosthetic membrane .
8774056	0	Alendronate	0,11	parathyroid_hormone	37,56	Alendronate	parathyroid hormone	MESH:D019386	5741	Chemical	Gene	stimulation|amod|START_ENTITY stimulation|nmod|secretion secretion|compound|END_ENTITY	Alendronate stimulation of nocturnal parathyroid_hormone secretion : a mechanism to explain the continued improvement in bone mineral density accompanying alendronate therapy .
9310349	0	Alendronate	0,11	protein-tyrosine-phosphatase-meg1	26,59	Alendronate	protein-tyrosine-phosphatase-meg1	MESH:D019386	5775	Chemical	Gene	START_ENTITY|dobj|inhibition inhibition|nmod|END_ENTITY	Alendronate inhibition of protein-tyrosine-phosphatase-meg1 .
12445725	0	Alexa_Fluor_647	42,57	RAPTOR	67,73	Alexa Fluor 647	RAPTOR	MESH:C569686	57521	Chemical	Gene	using|dobj|START_ENTITY using|nmod|END_ENTITY	Improved fluoroimmunoassays using the dye Alexa_Fluor_647 with the RAPTOR , a fiber optic biosensor .
10834668	0	Alfentanil	0,10	interleukin-2	43,56	Alfentanil	interleukin-2	MESH:D015760	3558	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|nmod|END_ENTITY	Alfentanil reduces the febrile response to interleukin-2 in humans .
1433183	0	Aliphatic_propargylamines	0,25	monoamine_oxidase_B	59,78	Aliphatic propargylamines	monoamine oxidase B	null	109731(Tax:10090)	Chemical	Gene	START_ENTITY|dep|inhibitors inhibitors|compound|END_ENTITY	Aliphatic_propargylamines : potent , selective , irreversible monoamine_oxidase_B inhibitors .
15662231	0	Aliskiren	0,9	renin	37,42	Aliskiren	renin	MESH:C446481	24715(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Aliskiren , a novel , orally effective renin inhibitor , lowers blood pressure in marmosets and spontaneously hypertensive rats .
17118124	0	Aliskiren	0,9	renin	36,41	Aliskiren	renin	MESH:C446481	5972	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Aliskiren , a novel orally effective renin inhibitor , exhibits similar pharmacokinetics and pharmacodynamics in Japanese and Caucasian subjects .
17198906	0	Aliskiren	0,9	renin	31,36	Aliskiren	renin	MESH:C446481	5972	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Aliskiren , an orally effective renin inhibitor , provides antihypertensive efficacy alone and in combination with valsartan .
17599805	0	Alkamides	0,9	cyclooxygenase-2	33,49	Alkamides	cyclooxygenase-2	null	5743	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|activity activity|amod|END_ENTITY	Alkamides from Echinacea inhibit cyclooxygenase-2 activity in human neuroglioma cells .
24376439	0	Alkane	0,6	alkB	25,29	Alkane	alkB	CHEBI:18310	8846	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Alkane hydroxylase gene -LRB- alkB -RRB- phylotype composition and diversity in northern Gulf of Mexico bacterioplankton .
24900262	0	Alkyl_Amine	27,38	Renin	39,44	Alkyl Amine	Renin	CHEBI:13759	5972	Chemical	Gene	Inhibitor|compound|START_ENTITY Inhibitor|compound|END_ENTITY	Discovery of VTP-27999 , an Alkyl_Amine Renin Inhibitor with Potential for Clinical Utility .
10421750	0	Alkylammonium	29,42	Mica	51,55	Alkylammonium	Mica	null	100507436	Chemical	Gene	Ions|compound|START_ENTITY Ions|nmod|END_ENTITY	Self-Assembled Monolayers of Alkylammonium Ions on Mica : Direct Determination of the Orientation of the Alkyl Chains .
19159217	0	Alkylhydroquinone	21,38	Tyrosinase	79,89	Alkylhydroquinone	Tyrosinase	null	22173(Tax:10090)	Chemical	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of an Alkylhydroquinone from Rhus succedanea as an Inhibitor of Tyrosinase and Melanogenesis .
17253679	0	Alkynylpyrimidine_amide	0,23	Tie-2	90,95	Alkynylpyrimidine amide	Tie-2	null	7010	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|inhibitors inhibitors|nmod|END_ENTITY	Alkynylpyrimidine_amide derivatives as potent , selective , and orally active inhibitors of Tie-2 kinase .
25887398	0	All-Trans-Retinoic_Acid	0,23	DRA	43,46	All-Trans-Retinoic Acid	DRA	MESH:D014212	1811	Chemical	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	All-Trans-Retinoic_Acid Increases SLC26A3 -LRB- DRA -RRB- Expression In Intestinal Epithelial Cells Via HNF-1b .
25887398	0	All-Trans-Retinoic_Acid	0,23	SLC26A3	34,41	All-Trans-Retinoic Acid	SLC26A3	MESH:D014212	1811	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	All-Trans-Retinoic_Acid Increases SLC26A3 -LRB- DRA -RRB- Expression In Intestinal Epithelial Cells Via HNF-1b .
26225425	0	All-Trans_Retinoic_Acid	0,23	TGF-b2	32,38	All-Trans Retinoic Acid	TGF-b2	MESH:D014212	7042	Chemical	Gene	Induces|nsubj|START_ENTITY Induces|dobj|END_ENTITY	All-Trans_Retinoic_Acid Induces TGF-b2 in Intestinal Epithelial Cells via RhoA - and p38a MAPK-Mediated Activation of the Transcription Factor ATF2 .
12393392	0	All-trans-retinoic_acid	0,23	CD52	32,36	All-trans-retinoic acid	CD52	MESH:D014212	1043	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nummod|END_ENTITY	All-trans-retinoic_acid induces CD52 expression in acute_promyelocytic_leukemia .
23300837	0	All-trans-retinoic_acid	0,23	ICAM-1	34,40	All-trans-retinoic acid	ICAM-1	MESH:D014212	3383	Chemical	Gene	modulates|amod|START_ENTITY END_ENTITY|nsubj|modulates	All-trans-retinoic_acid modulates ICAM-1 N-glycan composition by influencing GnT-III levels and inhibits cell adhesion and trans-endothelial migration .
10815802	0	All-trans-retinoic_acid	0,23	TNF	36,39	All-trans-retinoic acid	TNF	MESH:D014212	7124	Chemical	Gene	upregulates|amod|START_ENTITY END_ENTITY|nsubj|upregulates	All-trans-retinoic_acid upregulates TNF receptors and potentiates TNF-induced activation of nuclear factors-kappaB , activated protein-1 and apoptosis in human lung_cancer cells .
14652353	0	All-trans-retinoic_acid	0,23	glycine_N-methyltransferase	40,67	All-trans-retinoic acid	glycine N-methyltransferase	MESH:D014212	25134(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	All-trans-retinoic_acid rapidly induces glycine_N-methyltransferase in a dose-dependent manner and reduces circulating methionine and homocysteine levels in rats .
15610518	0	All-trans-retinoic_acid	0,23	interleukin-8	32,45	All-trans-retinoic acid	interleukin-8	MESH:D014212	3576	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	All-trans-retinoic_acid induces interleukin-8 via the nuclear factor-kappaB and p38_mitogen-activated_protein_kinase pathways in normal human keratinocytes .
25482166	0	All-trans_Retinoic_Acid	43,66	Tal2	30,34	All-trans Retinoic Acid	Tal2	MESH:D014212	21350(Tax:10090)	Chemical	Gene	Gene|nmod|START_ENTITY Gene|compound|END_ENTITY	Transcriptional Regulation of Tal2 Gene by All-trans_Retinoic_Acid -LRB- atRA -RRB- in P19 Cells .
20673043	0	All-trans_retinoic_Acid	0,23	cx43	34,38	All-trans retinoic Acid	cx43	MESH:D014212	2697	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	All-trans_retinoic_Acid regulates cx43 expression , gap junction communication and differentiation in primary lens epithelial cells .
20576349	0	All-trans_retinoic_acid	0,23	ALK	38,41	All-trans retinoic acid	ALK	MESH:D014212	238	Chemical	Gene	downregulates|amod|START_ENTITY END_ENTITY|nsubj|downregulates	All-trans_retinoic_acid downregulates ALK in neuroblastoma cell lines and induces apoptosis in neuroblastoma cell lines with activated ALK .
9113387	0	All-trans_retinoic_acid	0,23	ALP	55,58	All-trans retinoic acid	ALP	MESH:D014212	250	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	All-trans_retinoic_acid inhibits dexamethasone-induced ALP activity and mineralization in human osteoblastic cell line SV HFO .
26240147	0	All-trans_retinoic_acid	0,23	BACE1	32,37	All-trans retinoic acid	BACE1	MESH:D014212	23821(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|compound|END_ENTITY	All-trans_retinoic_acid reduces BACE1 expression under inflammatory conditions via modulation of NFkB signaling .
25957888	0	All-trans_retinoic_acid	0,23	CD2AP	47,52	All-trans retinoic acid	CD2AP	MESH:D014212	23607	Chemical	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|compound|END_ENTITY	All-trans_retinoic_acid up-regulates the human CD2AP gene expression through Sp1/Sp3 binding sites .
24851929	0	All-trans_retinoic_acid	0,23	Cdk5	64,68	All-trans retinoic acid	Cdk5	MESH:D014212	1020	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|amod|END_ENTITY	All-trans_retinoic_acid induces DU145 cell cycle arrest through Cdk5 activation .
22910408	0	All-trans_retinoic_acid	0,23	E-cadherin	34,44	All-trans retinoic acid	E-cadherin	MESH:D014212	999	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|amod|END_ENTITY	All-trans_retinoic_acid activates E-cadherin expression via promoter hypomethylation in the human colon_carcinoma HCT116 cells .
9620283	0	All-trans_retinoic_acid	0,23	Fas_antigen	34,45	All-trans retinoic acid	Fas antigen	MESH:D014212	355	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	All-trans_retinoic_acid modulates Fas_antigen expression and affects cell proliferation and apoptosis in combination with anti-Fas monoclonal antibody in the human myeloma cell line , U266B1 .
10503735	0	All-trans_retinoic_acid	0,23	ICAM-1	84,90	All-trans retinoic acid	ICAM-1	MESH:D014212	3383	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|expression expression|compound|END_ENTITY	All-trans_retinoic_acid inhibits the growth of breast_cancer cells by up-regulating ICAM-1 expression .
21159206	0	All-trans_retinoic_acid	0,23	KIT	33,36	All-trans retinoic acid	KIT	MESH:D014212	3815	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	All-trans_retinoic_acid inhibits KIT activity and induces apoptosis in gastrointestinal_stromal_tumor GIST-T1 cell line by affecting on the expression of survivin and Bax protein .
19486889	0	All-trans_retinoic_acid	0,23	KLF4	111,115	All-trans retinoic acid	KLF4	MESH:D014212	9314	Chemical	Gene	increases|amod|START_ENTITY KLF4|nsubj|increases KLF4|advcl|inducing inducing|nmod|END_ENTITY	All-trans_retinoic_acid increases KLF4 acetylation by inducing HDAC2 phosphorylation and its dissociation from KLF4 in vascular smooth muscle cells .
19486889	0	All-trans_retinoic_acid	0,23	KLF4	34,38	All-trans retinoic acid	KLF4	MESH:D014212	9314	Chemical	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	All-trans_retinoic_acid increases KLF4 acetylation by inducing HDAC2 phosphorylation and its dissociation from KLF4 in vascular smooth muscle cells .
24204796	0	All-trans_retinoic_acid	0,23	ORMDL3	34,40	All-trans retinoic acid	ORMDL3	MESH:D014212	94103	Chemical	Gene	modulates|amod|START_ENTITY END_ENTITY|nsubj|modulates	All-trans_retinoic_acid modulates ORMDL3 expression via transcriptional regulation .
11697504	0	All-trans_retinoic_acid	0,23	P-glycoprotein	98,112	All-trans retinoic acid	P-glycoprotein	MESH:D014212	5243	Chemical	Gene	differentiates|nsubj|START_ENTITY differentiates|dobj|cells cells|nmod|END_ENTITY	All-trans_retinoic_acid -LRB- ATRA -RRB- differentiates acute_promyelocytic_leukemia cells independently of P-glycoprotein -LRB- P-gp -RRB- related multidrug resistance .
19789299	0	All-trans_retinoic_acid	0,23	Stat3	35,40	All-trans retinoic acid	Stat3	MESH:D014212	20848(Tax:10090)	Chemical	Gene	suppresses|amod|START_ENTITY END_ENTITY|nsubj|suppresses	All-trans_retinoic_acid suppresses Stat3 signaling during skin_carcinogenesis .
21237205	0	All-trans_retinoic_acid	0,23	TLR-5	32,37	All-trans retinoic acid	TLR-5	MESH:D014212	7100	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	All-trans_retinoic_acid induces TLR-5 expression and cell differentiation and promotes flagellin-mediated cell functions in human THP-1 cells .
19324018	0	All-trans_retinoic_acid	0,23	Thrombospondin-1	32,48	All-trans retinoic acid	Thrombospondin-1	MESH:D014212	7057	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	All-trans_retinoic_acid induces Thrombospondin-1 expression in acute_promyelocytic_leukemia cells though down-regulation of its transcription repressor , c-MYC oncoprotein .
23554794	0	All-trans_retinoic_acid	0,23	VEGF	36,40	All-trans retinoic acid	VEGF	MESH:D014212	7422	Chemical	Gene	upregulates|amod|START_ENTITY END_ENTITY|nsubj|upregulates	All-trans_retinoic_acid upregulates VEGF expression in glioma cells in vitro .
16530516	0	All-trans_retinoic_acid	0,23	XAF1	32,36	All-trans retinoic acid	XAF1	MESH:D014212	327959(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	All-trans_retinoic_acid induces XAF1 expression through an interferon_regulatory_factor-1 element in colon_cancer .
21385580	0	All-trans_retinoic_acid	0,23	apolipoprotein_E	52,68	All-trans retinoic acid	apolipoprotein E	MESH:D014212	25728(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	All-trans_retinoic_acid regulates the expression of apolipoprotein_E in rats with glomerulosclerosis induced by Adriamycin .
17097063	0	All-trans_retinoic_acid	0,23	aquaporin-5	48,59	All-trans retinoic acid	aquaporin-5	MESH:D014212	11830(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	All-trans_retinoic_acid increases expression of aquaporin-5 and plasma membrane water permeability via transactivation of Sp1 in mouse lung epithelial cells .
8558945	0	All-trans_retinoic_acid	0,23	cathepsin_G	42,53	All-trans retinoic acid	cathepsin G	MESH:D014212	1511	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|xcomp|END_ENTITY	All-trans_retinoic_acid rapidly decreases cathepsin_G synthesis and mRNA expression in acute_promyelocytic_leukemia .
23298258	0	All-trans_retinoic_acid	0,23	collagen_8A2	124,136	All-trans retinoic acid	collagen 8A2	MESH:D014212	1296	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|END_ENTITY	All-trans_retinoic_acid protects hepatocellular_carcinoma cells against serum-starvation-induced cell death by upregulating collagen_8A2 .
19068145	0	All-trans_retinoic_acid	0,23	interleukin-6	35,48	All-trans retinoic acid	interleukin-6	MESH:D014212	24498(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	All-trans_retinoic_acid suppresses interleukin-6 expression in interleukin-1-stimulated synovial fibroblasts by inhibition of ERK1/2 pathway independently of RAR activation .
24440757	0	All-trans_retinoic_acid	0,23	miR-23a	39,46	All-trans retinoic acid	miR-23a	MESH:D014212	407010	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	All-trans_retinoic_acid -LRB- ATRA -RRB- induces miR-23a expression , decreases CTSC expression and granzyme_B activity leading to impaired NK cell cytotoxicity .
11986958	0	All-trans_retinoic_acid	0,23	prion_protein	39,52	All-trans retinoic acid	prion protein	MESH:D014212	5621	Chemical	Gene	down-regulates|amod|START_ENTITY END_ENTITY|nsubj|down-regulates	All-trans_retinoic_acid down-regulates prion_protein expression independently of granulocyte maturation .
7949172	0	All-trans_retinoic_acid	0,23	thrombomodulin	156,170	All-trans retinoic acid	thrombomodulin	MESH:D014212	7056	Chemical	Gene	thrombomodulin|amod|START_ENTITY thrombomodulin|dep|expression expression|nmod|factor factor|compound|END_ENTITY	All-trans_retinoic_acid upregulates thrombomodulin and downregulates tissue-factor expression in acute_promyelocytic_leukemia cells : distinct expression of thrombomodulin and tissue factor in human leukemic cells .
16322068	0	All-trans_retinoic_acid	0,23	vascular_endothelial_growth_factor	33,67	All-trans retinoic acid	vascular endothelial growth factor	MESH:D014212	7422	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	All-trans_retinoic_acid inhibits vascular_endothelial_growth_factor expression in a cell model of neutrophil activation .
25473931	0	Allicin	0,7	inducible_nitric_oxide_synthase	122,153	Allicin	inducible nitric oxide synthase	MESH:C006452	4843	Chemical	Gene	protects|nsubj|START_ENTITY protects|advcl|regulating regulating|dobj|END_ENTITY	Allicin protects spinal cord neurons from glutamate-induced oxidative stress through regulating the heat_shock_protein_70 / inducible_nitric_oxide_synthase pathway .
26571421	0	Allopurinol	24,35	Insulin	45,52	Allopurinol	Insulin	MESH:D000493	3630	Chemical	Gene	Resistance|compound|START_ENTITY Resistance|compound|END_ENTITY	Lowering Uric_Acid With Allopurinol Improves Insulin Resistance and Systemic_Inflammation in Asymptomatic Hyperuricemia .
3570982	2	Allosamidin	51,62	chitinase	79,88	Allosamidin	chitinase	MESH:C054851	693039(Tax:7091)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Allosamidin , a novel insect chitinase inhibitor .
17045574	0	Alloxan	0,7	O-GlcNAc-selective_N-acetyl-beta-D-glucosaminidase	27,77	Alloxan	O-GlcNAc-selective N-acetyl-beta-D-glucosaminidase	MESH:D000496	10724	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Alloxan is an inhibitor of O-GlcNAc-selective_N-acetyl-beta-D-glucosaminidase .
17045574	3	Alloxan	421,428	O-GlcNAcase	445,456	Alloxan	O-GlcNAcase	MESH:D000496	10724	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|dobj|END_ENTITY	Alloxan inhibited islet O-GlcNAcase with a dose-response much like that of STZ .
21472349	0	Allyl_isothiocyanate	0,20	Cdc25B	115,121	Allyl isothiocyanate	Cdc25B	MESH:C004471	994	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|down-regulation down-regulation|nmod|END_ENTITY	Allyl_isothiocyanate induces G2/M arrest in human colorectal_adenocarcinoma SW620 cells through down-regulation of Cdc25B and Cdc25C .
24672635	0	Allyl_isothiocyanate	0,20	MRP1	31,35	Allyl isothiocyanate	MRP1	MESH:C004471	4363	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|function function|compound|END_ENTITY	Allyl_isothiocyanate increases MRP1 function and expression in a human bronchial epithelial cell line .
22131196	0	Allyl_isothiocyanate	0,20	paraoxonase-1	47,60	Allyl isothiocyanate	paraoxonase-1	MESH:C004471	18979(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|inducer inducer|nmod|END_ENTITY	Allyl_isothiocyanate as a potential inducer of paraoxonase-1 -- studies in cultured hepatocytes and in mice .
25069801	0	Allyl_isothiocyanate	0,20	pregnane_X_receptor	37,56	Allyl isothiocyanate	pregnane X receptor	MESH:C004471	8856	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Allyl_isothiocyanate -LRB- AITC -RRB- inhibits pregnane_X_receptor -LRB- PXR -RRB- and constitutive_androstane_receptor -LRB- CAR -RRB- activation and protects against acetaminophen - and amiodarone-induced cytotoxicity .
18628250	0	Allyl_mercaptan	0,15	histone_deacetylase	66,85	Allyl mercaptan	histone deacetylase	CHEBI:59723	9734	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Allyl_mercaptan , a garlic-derived organosulfur compound , inhibits histone_deacetylase and enhances Sp3 binding on the P21WAF1 promoter .
26003845	0	Allyl_methyl_disulfide	0,22	IL-8	32,36	Allyl methyl disulfide	IL-8	MESH:C054528	3576	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|amod|END_ENTITY	Allyl_methyl_disulfide inhibits IL-8 and IP-10 secretion in intestinal epithelial cells via the NF - B signaling pathway .
18990727	0	Allylnitrile	0,12	CYP2E1	27,33	Allylnitrile	CYP2E1	MESH:C015660	13106(Tax:10090)	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|nmod|END_ENTITY	Allylnitrile metabolism by CYP2E1 and other CYPs leads to distinct lethal and vestibulotoxic effects in the mouse .
10403123	0	Aloesin	0,7	tyrosinase	28,38	Aloesin	tyrosinase	MESH:C069868	7299	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|activity activity|amod|END_ENTITY	Aloesin and arbutin inhibit tyrosinase activity in a synergistic manner via a different action mechanism .
26597690	0	Alofanib	27,35	Fibroblast_Growth_Factor_Receptor_2	64,99	Alofanib	Fibroblast Growth Factor Receptor 2	null	2263	Chemical	Gene	Activity|nmod|START_ENTITY Activity|appos|Inhibitor Inhibitor|nmod|END_ENTITY	Antiangiogenic Activity of Alofanib , an Allosteric Inhibitor of Fibroblast_Growth_Factor_Receptor_2 .
21437125	0	Alogliptin	0,10	DPP-4	43,48	Alogliptin	DPP-4	MESH:C520853	1803	Chemical	Gene	START_ENTITY|dep|addition addition|nmod|class class|nmod|inhibitors inhibitors|compound|END_ENTITY	Alogliptin : a new addition to the class of DPP-4 inhibitors .
24993124	0	Alogliptin	0,10	DPP-4	54,59	Alogliptin	DPP-4	MESH:C520853	1803	Chemical	Gene	START_ENTITY|dep|review review|nmod|inhibitor inhibitor|appos|END_ENTITY	Alogliptin ; a review of a new dipeptidyl_peptidase-4 -LRB- DPP-4 -RRB- inhibitor for the treatment of type_2_diabetes_mellitus .
25158388	0	Alogliptin	1,11	DPP-4	35,40	Alogliptin	DPP-4	MESH:C520853	1803	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	-LSB- Alogliptin -LRB- Vipidia -RRB- : a selective DPP-4 inhibitor with a good cardiovascular safety -RSB- .
25770025	0	Alogliptin	34,44	Dipeptidyl-Peptidase-4	0,22	Alogliptin	Dipeptidyl-Peptidase-4	MESH:C520853	13482(Tax:10090)	Chemical	Gene	Arterial_Inflammation|appos|START_ENTITY Arterial_Inflammation|compound|END_ENTITY	Dipeptidyl-Peptidase-4 Inhibitor , Alogliptin , Attenuates Arterial_Inflammation and Neointimal Formation After Injury in Low-Density_Lipoprotein _ -LRB- LDL -RRB- _ Receptor-Deficient Mice .
26628419	0	Alogliptin	0,10	Dipeptidyl_Peptidase-4	14,36	Alogliptin	Dipeptidyl Peptidase-4	MESH:C520853	1803	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|compound|END_ENTITY	Alogliptin , a Dipeptidyl_Peptidase-4 Inhibitor , Prevents the Progression of Carotid_Atherosclerosis in Patients With Type_2_Diabetes : The Study of Preventive Effects of Alogliptin on Diabetic_Atherosclerosis -LRB- SPEAD-A -RRB- .
26628419	0	Alogliptin	169,179	Dipeptidyl_Peptidase-4	14,36	Alogliptin	Dipeptidyl Peptidase-4	MESH:C520853	1803	Chemical	Gene	Effects|nmod|START_ENTITY Study|nmod|Effects Patients|dep|Study Carotid_Atherosclerosis|nmod|Patients Progression|nmod|Carotid_Atherosclerosis Prevents|dobj|Progression Prevents|nsubj|Alogliptin Alogliptin|appos|Inhibitor Inhibitor|compound|END_ENTITY	Alogliptin , a Dipeptidyl_Peptidase-4 Inhibitor , Prevents the Progression of Carotid_Atherosclerosis in Patients With Type_2_Diabetes : The Study of Preventive Effects of Alogliptin on Diabetic_Atherosclerosis -LRB- SPEAD-A -RRB- .
19191685	0	Alogliptin	0,10	dipeptidyl_peptidase-4	36,58	Alogliptin	dipeptidyl peptidase-4	MESH:C520853	1803	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Alogliptin : a new , highly selective dipeptidyl_peptidase-4 inhibitor for the treatment of type 2 diabetes .
24285765	0	Alogliptin	0,10	dipeptidyl_peptidase-4	18,40	Alogliptin	dipeptidyl peptidase-4	MESH:C520853	1803	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Alogliptin : a new dipeptidyl_peptidase-4 inhibitor for type_2_diabetes_mellitus .
24375601	0	Alogliptin	0,10	dipeptidyl_peptidase-4	18,40	Alogliptin	dipeptidyl peptidase-4	MESH:C520853	1803	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Alogliptin : A new dipeptidyl_peptidase-4 inhibitor for the management of type_2_diabetes_mellitus .
24993124	0	Alogliptin	0,10	dipeptidyl_peptidase-4	30,52	Alogliptin	dipeptidyl peptidase-4	MESH:C520853	1803	Chemical	Gene	START_ENTITY|dep|review review|nmod|inhibitor inhibitor|amod|END_ENTITY	Alogliptin ; a review of a new dipeptidyl_peptidase-4 -LRB- DPP-4 -RRB- inhibitor for the treatment of type_2_diabetes_mellitus .
25208188	0	Alogliptin	0,10	dipeptidyl_peptidase-4	18,40	Alogliptin	dipeptidyl peptidase-4	MESH:C520853	1803	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Alogliptin : a new dipeptidyl_peptidase-4 inhibitor with potential anti-atherogenic properties .
25757661	0	Alogliptin	0,10	dipeptidyl_peptidase-4	14,36	Alogliptin	dipeptidyl peptidase-4	MESH:C520853	100341424(Tax:9986)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Alogliptin , a dipeptidyl_peptidase-4 inhibitor , regulates the atrial arrhythmogenic substrate in rabbits .
18393107	0	Alogliptin	0,10	dipeptidyl_peptidase-IV	35,58	Alogliptin	dipeptidyl peptidase-IV	MESH:C520853	1803	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Alogliptin , a potent and selective dipeptidyl_peptidase-IV inhibitor for the treatment of type 2 diabetes .
23602966	0	Alogliptin	0,10	dipeptidylpeptidase-4	14,35	Alogliptin	dipeptidylpeptidase-4	MESH:C520853	1803	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Alogliptin , a dipeptidylpeptidase-4 inhibitor , for patients with diabetes_mellitus_type_2 , induces tolerance to focal cerebral_ischemia in non-diabetic , normal mice .
25290554	0	Alpha-Tocopherol	32,48	VEGF	13,17	Alpha-Tocopherol	VEGF	MESH:D024502	7422	Chemical	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	Induction of VEGF Expression by Alpha-Tocopherol and Alpha-Tocopheryl_Phosphate via PI3Ky/PKB and hTAP1/SEC14L2-Mediated Lipid Exchange .
18275039	0	Alpha-alkyl_substituted_pirinixic_acid	0,38	peroxisome_proliferator_activated_receptor_alpha	82,130	Alpha-alkyl substituted pirinixic acid	peroxisome proliferator activated receptor alpha	null	5465	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Alpha-alkyl_substituted_pirinixic_acid derivatives as potent dual agonists of the peroxisome_proliferator_activated_receptor_alpha and gamma .
12834005	0	Alpha-asarone	0,13	HMG-CoA_reductase	23,40	Alpha-asarone	HMG-CoA reductase	MESH:C012195	25675(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Alpha-asarone inhibits HMG-CoA_reductase , lowers serum LDL-cholesterol levels and reduces biliary CSI in hypercholesterolemic rats .
16387404	0	Alpha-chaconine	0,15	caspase-3	101,110	Alpha-chaconine	caspase-3	MESH:C011860	836	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|amod|END_ENTITY	Alpha-chaconine , a potato_glycoalkaloid , induces apoptosis of HT-29 human colon_cancer cells through caspase-3 activation and inhibition of ERK_1 / 2 phosphorylation .
15015763	0	Alpha-difluoromethylornithine	0,29	ornithine_decarboxylase	31,54	Alpha-difluoromethylornithine	ornithine decarboxylase	CHEBI:41948	4953	Chemical	Gene	cytotoxicity|amod|START_ENTITY cytotoxicity|amod|END_ENTITY	Alpha-difluoromethylornithine , ornithine_decarboxylase inhibitor , antagonizes H2O2-induced cytotoxicity in HL-60_leukemia cells : regulation of iron-dependent lysosomal damage .
17280490	0	Alpha-lipoic_Acid	0,17	heat_shock_factor-1	28,47	Alpha-lipoic Acid	heat shock factor-1	MESH:D008063	79245(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	Alpha-lipoic_Acid modulates heat_shock_factor-1 expression in streptozotocin-induced_diabetic rat kidney .
20814740	0	Alpha-lipoic_acid	0,17	GFAP	28,32	Alpha-lipoic acid	GFAP	MESH:D008063	2670	Chemical	Gene	modulates|amod|START_ENTITY END_ENTITY|nsubj|modulates	Alpha-lipoic_acid modulates GFAP , vimentin , nestin , cyclin_D1 and MAP-kinase expression in astroglial cell cultures .
11689467	0	Alpha-lipoic_acid	0,17	NF-kappaB	45,54	Alpha-lipoic acid	NF-kappaB	MESH:D008063	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|compound|END_ENTITY	Alpha-lipoic_acid inhibits TNF-alpha-induced NF-kappaB activation and adhesion molecule expression in human aortic endothelial cells .
20153726	0	Alpha-lipoic_acid	0,17	PAI-1	35,40	Alpha-lipoic acid	PAI-1	MESH:D008063	18787(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Alpha-lipoic_acid inhibits hepatic PAI-1 expression and fibrosis by inhibiting the TGF-beta signaling pathway .
18182252	0	Alpha-lipoic_acid	0,17	TNF-alpha	27,36	Alpha-lipoic acid	TNF-alpha	MESH:D008063	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Alpha-lipoic_acid inhibits TNF-alpha induced NF-kappa_B activation through blocking of MEKK1-MKK4-IKK signaling cascades .
22819708	0	Alpha-lipoic_acid	0,17	adipose_triglyceride_lipase	26,53	Alpha-lipoic acid	adipose triglyceride lipase	MESH:D008063	57104	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Alpha-lipoic_acid induces adipose_triglyceride_lipase expression and decreases intracellular lipid accumulation in HepG2 cells .
20603107	0	Alpha-lipoic_acid	0,17	dimethylarginine_dimethylaminohydrolase	28,67	Alpha-lipoic acid	dimethylarginine dimethylaminohydrolase	MESH:D008063	23576	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Alpha-lipoic_acid activates dimethylarginine_dimethylaminohydrolase in cultured endothelial cells .
17334234	0	Alpha-lipoic_acid	0,17	matrix_metalloproteinase-9	27,53	Alpha-lipoic acid	matrix metalloproteinase-9	MESH:D008063	4318	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Alpha-lipoic_acid inhibits matrix_metalloproteinase-9 expression by inhibiting NF-kappaB transcriptional activity .
24894151	0	Alpha-mangostin	0,15	fatty_acid_synthase	39,58	Alpha-mangostin	fatty acid synthase	MESH:C021053	2194	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Alpha-mangostin inhibits intracellular fatty_acid_synthase and induces apoptosis in breast_cancer cells .
7337069	0	Alpha-methylhistamine	0,21	histamine_methyltransferase	37,64	Alpha-methylhistamine	histamine methyltransferase	MESH:C069357	3176	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	Alpha-methylhistamine methylation by histamine_methyltransferase .
17118655	0	Alpha-methyltryptamine_sulfonamide	0,34	glucocorticoid_receptor	56,79	Alpha-methyltryptamine sulfonamide	glucocorticoid receptor	MESH:C518581	2908	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Alpha-methyltryptamine_sulfonamide derivatives as novel glucocorticoid_receptor ligands .
11290823	0	Alpha-tocopherol	0,16	CD36	27,31	Alpha-tocopherol	CD36	MESH:D024502	948	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|nummod|END_ENTITY	Alpha-tocopherol decreases CD36 expression in human monocyte-derived macrophages .
15721988	0	Alpha-tocopherol	0,16	Cyp3a	27,32	Alpha-tocopherol	Cyp3a	MESH:D024502	13112(Tax:10090)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	Alpha-tocopherol modulates Cyp3a expression , increases gamma-CEHC production , and limits tissue gamma-tocopherol accumulation in mice fed high gamma-tocopherol diets .
11270503	0	Alpha-tocopherol	0,16	Mac-1	43,48	Alpha-tocopherol	Mac-1	MESH:D024502	3684	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|END_ENTITY	Alpha-tocopherol protects against monocyte Mac-1 -LRB- CD11b/CD18 -RRB- expression and Mac-1-dependent adhesion to endothelial cells induced by oxidized low-density lipoprotein .
16908007	0	Alpha-tocopherol	0,16	calnexin	25,33	Alpha-tocopherol	calnexin	MESH:D024502	29144(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Alpha-tocopherol induces calnexin in renal tubular cells : another protective mechanism against free radical-induced cellular damage .
12522127	0	Alpha-tocopherol	0,16	connective_tissue_growth_factor	39,70	Alpha-tocopherol	connective tissue growth factor	MESH:D024502	1490	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Alpha-tocopherol induces expression of connective_tissue_growth_factor and antagonizes tumor_necrosis_factor-alpha-mediated downregulation in human smooth muscle cells .
12773205	0	Alpha-tocopherol	0,16	low_density_lipoprotein_receptor	31,63	Alpha-tocopherol	low density lipoprotein receptor	MESH:D024502	3949	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Alpha-tocopherol modulates the low_density_lipoprotein_receptor of human HepG2 cells .
7862258	0	Alpha-trinositol	0,16	NPY	50,53	Alpha-trinositol	NPY	MESH:C059368	100724008	Chemical	Gene	blocks|nsubj|START_ENTITY blocks|dobj|effects effects|nmod|END_ENTITY	Alpha-trinositol blocks the inhibitory effects of NPY on dilatation to forskolin but not the adenylyl cyclase activity induced by NPY or forskolin in guinea-pig cerebral vessels .
11026561	0	Alpha2-HSG	0,10	insulin_receptor	93,109	Alpha2-HSG	insulin receptor	null	3643	Chemical	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Alpha2-HSG , a specific inhibitor of insulin_receptor autophosphorylation , interacts with the insulin_receptor .
7862886	0	Alphaxalone	0,11	corticotropin_releasing_factor	77,107	Alphaxalone	corticotropin releasing factor	MESH:C006477	1392	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|effects effects|nmod|END_ENTITY	Alphaxalone , a steroid anesthetic , inhibits the startle-enhancing effects of corticotropin_releasing_factor , but not strychnine .
24104193	0	Alpinetin	0,9	PPAR-y	76,82	Alpinetin	PPAR-y	MESH:C436748	5468	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|activating activating|dobj|END_ENTITY	Alpinetin inhibits LPS-induced inflammatory mediator response by activating PPAR-y in THP-1-derived macrophages .
15806426	0	Alprazolam	0,10	CYP3A	26,31	Alprazolam	CYP3A	MESH:D000525	1576	Chemical	Gene	START_ENTITY|nmod|probe probe|nmod|END_ENTITY	Alprazolam as a probe for CYP3A using a single blood sample : pharmacokinetics of parent drug , and of alpha - _ and_4-hydroxy metabolites in healthy subjects .
22406678	0	Alternariol	0,11	polymerase_b	24,36	Alternariol	polymerase b	MESH:C005197	5423	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Alternariol induces DNA polymerase_b expression through the PKA-CREB signaling pathway .
26843017	0	Alu	77,80	FXIIIB	106,112	Alu	FXIIIB	null	2165	Chemical	Gene	Polymorphisms|compound|START_ENTITY Polymorphisms|appos|END_ENTITY	Development of Novel High-Resolution Melting-Based Assays for Genotyping Two Alu Insertion Polymorphisms -LRB- FXIIIB and PV92 -RRB- .
21761136	0	Alu	3,6	GCNT2	31,36	Alu	GCNT2	null	2651	Chemical	Gene	deletion|compound|START_ENTITY deletion|compound|END_ENTITY	An Alu repeat-mediated genomic GCNT2 deletion underlies congenital_cataracts and adult i blood group .
10625605	0	Alu	3,6	K18	24,27	Alu	K18	null	16668(Tax:10090)	Chemical	Gene	element|compound|START_ENTITY element|nmod|gene gene|compound|END_ENTITY	An Alu element from the K18 gene confers position-independent expression in transgenic_mice .
15340835	0	Alu	13,16	MSH2	8,12	Alu	MSH2	null	4436	Chemical	Gene	mutation|compound|START_ENTITY mutation|compound|END_ENTITY	A large MSH2 Alu insertion mutation causes HNPCC in a German kindred .
21236316	0	Alu	55,58	NF1	74,77	Alu	NF1	null	4763	Chemical	Gene	element|compound|START_ENTITY element|nmod|gene gene|compound|END_ENTITY	A functional tetranucleotide -LRB- AAAT -RRB- polymorphism in an Alu element in the NF1 gene is associated with mental_retardation .
16093706	0	Alu	4,7	Yc1	8,11	Alu	Yc1	null	5937	Chemical	Gene	subfamily|compound|START_ENTITY subfamily|compound|END_ENTITY	The Alu Yc1 subfamily : sorting the wheat from the chaff .
1328942	0	Aluminium	0,9	erythropoietin	53,67	Aluminium	erythropoietin	CHEBI:28984	2056	Chemical	Gene	overload|compound|START_ENTITY overload|nmod|END_ENTITY	Aluminium overload and response to recombinant human erythropoietin in patients under chronic haemodialysis .
10882551	0	Aluminium	0,9	vitellogenin	30,42	Aluminium	vitellogenin	CHEBI:28984	100136735(Tax:8022)	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|END_ENTITY	Aluminium and cadmium inhibit vitellogenin and its mRNA induction by estradiol-17 beta in the primary culture of hepatocytes in the rainbow_trout Oncorhynchus_mykiss .
2517032	0	Aluminium_fluoride	0,18	phospholipase_A2	28,44	Aluminium fluoride	phospholipase A2	null	151056	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|amod|END_ENTITY	Aluminium_fluoride enhances phospholipase_A2 activity and eicosanoid synthesis in macrophages .
23065425	0	Aluminum	0,8	JNK	76,79	Aluminum	JNK	MESH:D000535	5599	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Aluminum induces osteoblast apoptosis through the oxidative stress-mediated JNK signaling pathway .
17112520	0	Aluminum	0,8	cathepsin_D	69,80	Aluminum	cathepsin D	MESH:D000535	1509	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Aluminum inhibits proteolytic degradation of amyloid beta peptide by cathepsin_D : a potential link between aluminum accumulation and neuritic_plaque_deposition .
10693977	0	Aluminum	0,8	transferrin	31,42	Aluminum	transferrin	MESH:D000535	24825(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|END_ENTITY	Aluminum uptake and effects on transferrin mediated iron uptake in primary cultures of rat neurons , astrocytes and oligodendrocytes .
12627980	0	Aluminum	0,8	transferrin	50,61	Aluminum	transferrin	MESH:D000535	7018	Chemical	Gene	exchange|nsubj|START_ENTITY exchange|nmod|END_ENTITY	Aluminum exchange between citrate and human serum transferrin and interaction with transferrin receptor 1 .
12627980	0	Aluminum	0,8	transferrin	83,94	Aluminum	transferrin	MESH:D000535	7018	Chemical	Gene	exchange|nsubj|START_ENTITY exchange|nmod|receptor receptor|compound|END_ENTITY	Aluminum exchange between citrate and human serum transferrin and interaction with transferrin receptor 1 .
2247478	0	Aluminum	0,8	transferrin	41,52	Aluminum	transferrin	MESH:D000535	7018	Chemical	Gene	access|compound|START_ENTITY access|dep|role role|nmod|END_ENTITY	Aluminum access to the brain : a role for transferrin and its receptor .
8782865	0	Aluminum	0,8	transferrin	68,79	Aluminum	transferrin	MESH:D000535	24825(Tax:10116)	Chemical	Gene	alters|nsubj|START_ENTITY alters|xcomp|iron iron|dobj|uptake uptake|nmod|receptors receptors|compound|END_ENTITY	Aluminum alters iron and manganese uptake and regulation of surface transferrin receptors in primary rat oligodendrocyte cultures .
9353887	0	Aluminum	0,8	transferrin	33,44	Aluminum	transferrin	MESH:D000535	7018	Chemical	Gene	structure|compound|START_ENTITY structure|nmod|END_ENTITY	Aluminum site structure in serum transferrin and lactoferrin revealed by synchrotron radiation X-ray spectroscopy .
25911756	0	Aluminum_Salt	59,72	Th2	90,93	Aluminum Salt	Th2	null	15111(Tax:10090)	Chemical	Gene	Responses|compound|START_ENTITY Responses|compound|END_ENTITY	Involvement of CD300a Phosphatidylserine Immunoreceptor in Aluminum_Salt Adjuvant-Induced Th2 Responses .
10561485	0	Aluminum_fluoride	0,17	phospholipase_D	40,55	Aluminum fluoride	phospholipase D	MESH:C032311	2822	Chemical	Gene	inhibition|amod|START_ENTITY END_ENTITY|nsubj|inhibition	Aluminum_fluoride inhibition of cabbage phospholipase_D by a phosphate-mimicking mechanism .
16987614	0	Alveolate	0,9	cox2	42,46	Alveolate	cox2	null	4513	Chemical	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Alveolate and chlorophycean mitochondrial cox2 genes split twice independently .
23624141	0	Am80	35,39	ADAM10	62,68	Am80	ADAM10	MESH:C061133	11487(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	The retinoic_acid receptor agonist Am80 increases hippocampal ADAM10 in aged SAMP8 mice .
26606052	0	Am80	24,28	Stra8	78,83	Am80	Stra8	MESH:C061133	417938(Tax:9031)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	The Induction Effect of Am80 and TSA on ESC Differentiation via Regulation of Stra8 in Chicken .
8566141	0	Amantadine	0,10	c-fos	19,24	Amantadine	c-fos	MESH:D000547	314322(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Amantadine induces c-fos in rat striatum : reversal with dopamine D1 and NMDA receptor antagonists .
21437134	0	Amantadine	0,10	insulin	41,48	Amantadine	insulin	MESH:D000547	3630	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|secretion secretion|compound|END_ENTITY	Amantadine reduces glucagon and enhances insulin secretion throughout the oral glucose tolerance test : central plus peripheral nervous system mechanisms .
681249	0	Amastatin	0,9	aminopeptidase_A	27,43	Amastatin	aminopeptidase A	MESH:C016977	2028	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Amastatin , an inhibitor of aminopeptidase_A , produced by actinomycetes .
16171436	0	Amelogenin	0,10	bone_sialoprotein	22,39	Amelogenin	bone sialoprotein	null	24477(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Amelogenin stimulates bone_sialoprotein -LRB- BSP -RRB- expression through fibroblast_growth_factor_2 response element and transforming_growth_factor-beta1 activation element in the promoter of the BSP gene .
12657653	0	Amelogenin	0,10	cytokeratin-5	26,39	Amelogenin	cytokeratin-5	null	3852	Chemical	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Amelogenin interacts with cytokeratin-5 in ameloblasts during enamel growth .
16084098	0	Amentoflavone	0,13	Cathepsin_B	71,82	Amentoflavone	Cathepsin B	MESH:C011164	1508	Chemical	Gene	START_ENTITY|dep|inhibitors inhibitors|nmod|END_ENTITY	Amentoflavone and its derivatives as novel natural inhibitors of human Cathepsin_B .
22205321	0	Amentoflavone	0,13	matrix_metalloproteinase-1	35,61	Amentoflavone	matrix metalloproteinase-1	MESH:C011164	4312	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Amentoflavone inhibits UVB-induced matrix_metalloproteinase-1 expression through the modulation of AP-1 components in normal human fibroblasts .
26985295	0	Amide	18,23	p97	38,41	Amide	p97	CHEBI:32988	4241	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|nmod|END_ENTITY	Allosteric Indole Amide Inhibitors of p97 : Identification of a Novel Probe of the Ubiquitin Pathway .
7582980	0	Amide	0,5	thrombin	44,52	Amide	thrombin	CHEBI:32988	2147	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Amide and alpha-keto_carbonyl inhibitors of thrombin based on arginine and lysine : synthesis , stability and biological characterization .
8236532	0	Amides	1,7	alcohol_dehydrogenase	69,90	Amides	alcohol dehydrogenase	MESH:D000577	78959(Tax:10116)	Chemical	Gene	START_ENTITY|dep|inhibitors inhibitors|nmod|END_ENTITY	-LSB- Amides of simple and complex ethers of glycolic_acid -- inhibitors of alcohol_dehydrogenase in rat and human liver -RSB- .
26140617	0	Amidine	131,138	BACE1	145,150	Amidine	BACE1	CHEBI:2634	23621	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|compound|END_ENTITY	A Versatile Approach to CF3 - Containing 2-Pyrrolidones by Tandem Michael Addition-Cyclization : Exemplification in the Synthesis of Amidine Class BACE1 Inhibitors .
26140617	0	Amidine	131,138	BACE1	145,150	Amidine	BACE1	CHEBI:2634	23621	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|compound|END_ENTITY	A Versatile Approach to CF3 - Containing 2-Pyrrolidones by Tandem Michael Addition-Cyclization : Exemplification in the Synthesis of Amidine Class BACE1 Inhibitors .
26178379	0	Amidine	131,138	BACE1	145,150	Amidine	BACE1	CHEBI:2634	23621	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|compound|END_ENTITY	A Versatile Approach to CF3 - Containing 2-Pyrrolidones by Tandem Michael Addition-Cyclization : Exemplification in the Synthesis of Amidine Class BACE1 Inhibitors .
26680714	0	Amidino-substituted_Benzimidazoles	54,88	Dipeptidyl_Peptidase_III	92,116	Amidino-substituted Benzimidazoles	Dipeptidyl Peptidase III	null	10072	Chemical	Gene	START_ENTITY|nmod|Inhibitors Inhibitors|compound|END_ENTITY	Synthesis , QSAR , and Molecular Dynamics Simulation of Amidino-substituted_Benzimidazoles as Dipeptidyl_Peptidase_III Inhibitors .
26101573	0	Amidopyrazole	21,34	IRAK4	49,54	Amidopyrazole	IRAK4	null	51135	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|nmod|END_ENTITY	Potent and Selective Amidopyrazole Inhibitors of IRAK4 That Are Efficacious in a Rodent Model of Inflammation .
26680986	0	Amifostine	24,34	IL-1beta	59,67	Amifostine	IL-1beta	MESH:D004999	16176(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	The Combined Effects of Amifostine and Interleukin_1_Beta -LRB- IL-1beta -RRB- on Radiation-induced Gastrointestinal and Hematopoietic_Injury .
11426556	0	Amifostine	0,10	erythropoietin	31,45	Amifostine	erythropoietin	MESH:D004999	2056	Chemical	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	Amifostine in combination with erythropoietin and G-CSF promotes multilineage hematopoiesis in patients with myelodysplastic_syndrome .
26890278	0	Amiloride	0,9	ASIC1a	21,27	Amiloride	ASIC1a	MESH:D000584	11419(Tax:10090)	Chemical	Gene	Analogs|compound|START_ENTITY Analogs|nmod|END_ENTITY	Amiloride Analogs as ASIC1a Inhibitors .
24966089	8	Amiloride	1113,1122	ENaC	1153,1157	Amiloride	ENaC	MESH:D000584	20276(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|appos|END_ENTITY	Amiloride , an epithelial_Na -LRB- + -RRB- _ channel -LRB- ENaC -RRB- inhibitor , normalized the BP of KO mice fed HK diets , suggesting that lack of Cyp2c44 in the CD enhances ENaC activity and increases Na -LRB- + -RRB- absorption in KO mice fed HK diets .
24959362	0	Amiloride	0,9	Plasmin	98,105	Amiloride	Plasmin	MESH:D000584	5340	Chemical	Gene	START_ENTITY|dep|Roles Roles|nmod|END_ENTITY	Amiloride as an Alternate Adjuvant Antiproteinuric Agent in Fabry_Disease : The Potential Roles of Plasmin and uPAR .
3348797	0	Amiloride	0,9	angiotensin_II	47,61	Amiloride	angiotensin II	MESH:D000584	183	Chemical	Gene	activation|amod|START_ENTITY kinase|nsubj|activation kinase|nmod|END_ENTITY	Amiloride sensitive activation of S6 kinase by angiotensin_II in cultured vascular smooth muscle cells .
2454102	0	Amiloride	0,9	atrial_natriuretic_factor	72,97	Amiloride	atrial natriuretic factor	MESH:D000584	4878	Chemical	Gene	increases|nsubj|START_ENTITY increases|nmod|END_ENTITY	Amiloride increases the sensitivity of particulate guanylate cyclase to atrial_natriuretic_factor .
2853740	0	Amiloride	0,9	atrial_natriuretic_factor	46,71	Amiloride	atrial natriuretic factor	MESH:D000584	24602(Tax:10116)	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|effects effects|nmod|END_ENTITY	Amiloride potentiates the vascular effects of atrial_natriuretic_factor .
3018411	0	Amiloride	0,9	atrial_natriuretic_factor	22,47	Amiloride	atrial natriuretic factor	MESH:D000584	281355(Tax:9913)	Chemical	Gene	potentiates|amod|START_ENTITY END_ENTITY|nsubj|potentiates	Amiloride potentiates atrial_natriuretic_factor inhibitory action by increasing receptor binding in bovine adrenal_zona_glomerulosa .
3106085	0	Amiloride	0,9	urokinase-type_plasminogen_activator	35,71	Amiloride	urokinase-type plasminogen activator	MESH:D000584	5328	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Amiloride selectively inhibits the urokinase-type_plasminogen_activator .
26345885	0	Amiloride	0,9	urokinase-type_plasminogen_activator_receptor	13,58	Amiloride	urokinase-type plasminogen activator receptor	MESH:D000584	5329	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Amiloride , a urokinase-type_plasminogen_activator_receptor -LRB- uTPA -RRB- inhibitor , reduces proteinurea in podocytes .
26345885	0	Amiloride	0,9	urokinase-type_plasminogen_activator_receptor	13,58	Amiloride	urokinase-type plasminogen activator receptor	MESH:D000584	5329	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Amiloride , a urokinase-type_plasminogen_activator_receptor -LRB- uTPA -RRB- inhibitor , reduces proteinurea in podocytes .
1400589	0	Amino	0,5	Gs_alpha	48,56	Amino	Gs alpha	CHEBI:46882	2778	Chemical	Gene	mutants|amod|START_ENTITY mutants|nmod|END_ENTITY	Amino - and carboxy-terminal deletion mutants of Gs_alpha are localized to the particulate fraction of transfected COS cells .
25532905	0	Amino	48,53	MAO-B	21,26	Amino	MAO-B	CHEBI:46882	4129	Chemical	Gene	activity|dep|START_ENTITY activity|compound|END_ENTITY	Potent and selective MAO-B inhibitory activity : Amino - versus nitro-3-arylcoumarin derivatives .
10848618	0	Amino	0,5	gastrin	49,56	Amino	gastrin	CHEBI:46882	25320(Tax:10116)	Chemical	Gene	mediate|nsubj|START_ENTITY mediate|dobj|stabilization stabilization|compound|END_ENTITY	Amino - and carboxy-terminal PEST domains mediate gastrin stabilization of rat L-histidine_decarboxylase isoforms .
1116670	0	Amino	0,5	gastrin	15,22	Amino	gastrin	CHEBI:46882	2520	Chemical	Gene	fragment|compound|START_ENTITY fragment|compound|END_ENTITY	Amino terminal gastrin fragment in serum of Zollinger-Ellison_syndrome patients .
8567186	0	Amino-acid	0,10	bone_Gla_protein	23,39	Amino-acid	bone Gla protein	CHEBI:33704	399370(Tax:8355)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino-acid sequence of bone_Gla_protein from the African clawed toad Xenopus_laevis and the fish Sparus aurata .
7665088	0	Amino-acid	0,10	leukotriene_A4_hydrolase	58,82	Amino-acid	leukotriene A4 hydrolase	CHEBI:33704	100135571(Tax:10141)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino-acid sequence and tissue distribution of guinea-pig leukotriene_A4_hydrolase .
1068454	0	Amino-acid	0,10	metallothionein-1B	36,54	Amino-acid	metallothionein-1B	CHEBI:33704	100630543	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino-acid sequence of equine renal metallothionein-1B .
7947957	0	Amino-acid	0,10	myoglobin	46,55	Amino-acid	myoglobin	CHEBI:33704	4151	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino-acid sequence of a cooperative , dimeric myoglobin from the gastropod mollusc , Buccinum undatum L .
8448171	0	Amino-acid	0,10	myoglobin	47,56	Amino-acid	myoglobin	CHEBI:33704	4151	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino-acid sequence of the cooperative dimeric myoglobin from the radular muscles of the marine gastropod Nassa mutabilis .
1418675	0	Amino-acid	0,10	myosin	79,85	Amino-acid	myosin	CHEBI:33704	395534(Tax:9031)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino-acid sequence of the short subfragment-2 in adult chicken cardiac muscle myosin .
2713098	0	Amino-acid	0,10	myosin	51,57	Amino-acid	myosin	CHEBI:33704	395534(Tax:9031)	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|nsubj|sequence	Amino-acid sequence of the hinge region in chicken myosin subfragment-2 .
9742454	0	Amino-acid	0,10	myosin_heavy_chain	29,47	Amino-acid	myosin heavy chain	CHEBI:33704	3133	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino-acid sequence of squid myosin_heavy_chain .
1055405	0	Amino-acid	0,10	parvalbumin	23,34	Amino-acid	parvalbumin	CHEBI:33704	100343964(Tax:9986)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino-acid sequence of parvalbumin from rabbit skeletal muscle .
7306589	0	Amino-acid	0,10	rhodopsin	68,77	Amino-acid	rhodopsin	CHEBI:33704	509933(Tax:9913)	Chemical	Gene	determination|amod|START_ENTITY determination|nmod|END_ENTITY	Amino-acid sequence determination of a hydrophobic region of bovine rhodopsin .
6708544	0	Amino-steroids	0,14	cytochrome_P-450scc	62,81	Amino-steroids	cytochrome P-450scc	null	1583	Chemical	Gene	START_ENTITY|nmod|site site|nmod|END_ENTITY	Amino-steroids as inhibitors and probes of the active site of cytochrome_P-450scc .
26875484	0	Amino_Acid	210,220	Asparagine_Synthetase	19,40	Amino Acid	Asparagine Synthetase	D000596	25612(Tax:10116)	Chemical	Gene	Imbalance|compound|START_ENTITY Related|nmod|Imbalance Related|nsubj|Regulation Regulation|nmod|END_ENTITY	Down Regulation of Asparagine_Synthetase and 3-Phosphoglycerate_Dehydrogenase , and the Up-Regulation of Serine_Dehydratase in Rat Liver from Intake of Excess Amount of Leucine Are Not Related to Leucine-Caused Amino_Acid Imbalance .
25254246	0	Amino_Acid	0,10	BACE1	49,54	Amino Acid	BACE1	CHEBI:33704	23621	Chemical	Gene	Sequence|compound|START_ENTITY Sequence|nmod|END_ENTITY	Amino_Acid Sequence and Structural Comparison of BACE1 and BACE2 Using Evolutionary Trace Method .
26364758	0	Amino_Acid	16,26	CCN2	8,12	Amino Acid	CCN2	D000596	1490	Chemical	Gene	Metabolism|compound|START_ENTITY Role|nmod|Metabolism Role|nmod|END_ENTITY	Role of CCN2 in Amino_Acid Metabolism of Chondrocytes .
26751093	0	Amino_Acid	46,56	CO2	12,15	Amino Acid	CO2	D000596	717	Chemical	Gene	Salt|compound|START_ENTITY Absorption|nmod|Salt Absorption|compound|END_ENTITY	Kinetics of CO2 Absorption into Aqueous Basic Amino_Acid Salt : Potassium Salt of Lysine Solution .
26007177	0	Amino_Acid	75,85	EAAC1	97,102	Amino Acid	EAAC1	D000596	6505	Chemical	Gene	Carrier|compound|START_ENTITY Carrier|appos|END_ENTITY	Glutathione in Cellular Redox Homeostasis : Association with the Excitatory Amino_Acid Carrier 1 -LRB- EAAC1 -RRB- .
26007177	0	Amino_Acid	75,85	EAAC1	97,102	Amino Acid	EAAC1	D000596	6505	Chemical	Gene	Carrier|compound|START_ENTITY Carrier|appos|END_ENTITY	Glutathione in Cellular Redox Homeostasis : Association with the Excitatory Amino_Acid Carrier 1 -LRB- EAAC1 -RRB- .
26269591	0	Amino_Acid	56,66	EAAT1	82,87	Amino Acid	EAAT1	D000596	6507	Chemical	Gene	Transporter|compound|START_ENTITY Regulation|nmod|Transporter Regulation|appos|END_ENTITY	Transcriptional Regulation of the Astrocytic Excitatory Amino_Acid Transporter 1 -LRB- EAAT1 -RRB- via NF-kB and Yin_Yang_1 -LRB- YY1 -RRB- .
26757239	0	Amino_Acid	82,92	EAAT1	118,123	Amino Acid	EAAT1	D000596	6507	Chemical	Gene	Subtype|compound|START_ENTITY Insight|nmod|Subtype Insight|appos|END_ENTITY	New Insight into the Structure-Activity Relationships of the Selective Excitatory Amino_Acid Transporter Subtype 1 -LRB- EAAT1 -RRB- Inhibitors UCPH-101 and UCPH-102 .
25323013	0	Amino_Acid	99,109	Insulin	23,30	Amino Acid	Insulin	CHEBI:33704	3630	Chemical	Gene	Profiles|compound|START_ENTITY Glucose|nmod|Profiles Secondary|xcomp|Glucose Secondary|nsubj|Impact Impact|nmod|Therapy Therapy|compound|END_ENTITY	The Negative Impact of Insulin Therapy for Acute Hyperglycemia Secondary to Glucose Load on Plasma Amino_Acid Profiles in a Rat Model of Sepsis .
26307831	0	Amino_Acid	27,37	Insulin	88,95	Amino Acid	Insulin	D000596	3630	Chemical	Gene	Nanoparticles|compound|START_ENTITY Nanoparticles|nmod|END_ENTITY	Chitosan-Modified Cationic Amino_Acid Nanoparticles as a Novel Oral Delivery System for Insulin .
24147211	0	Amino_Acid	0,10	Integrin_Alpha_4	76,92	Amino Acid	Integrin Alpha 4	CHEBI:33704	16401(Tax:10090)	Chemical	Gene	Binding|compound|START_ENTITY Binding|nmod|END_ENTITY	Amino_Acid Sequences Mediating Vascular_Cell_Adhesion_Molecule_1 Binding to Integrin_Alpha_4 : Homologous DSP Sequence Found for JC Polyoma VP1 Coat Protein .
26944194	0	Amino_Acid	53,63	LAT-1	79,84	Amino Acid	LAT-1	D000596	8140	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Aryl_hydrocarbon receptor -LRB- AHR -RRB- regulation of L-Type Amino_Acid Transporter 1 -LRB- LAT-1 -RRB- expression in MCF-7 and MDA-MB-231 breast_cancer cells .
25597310	0	Amino_Acid	33,43	LAT1	8,12	Amino Acid	LAT1	CHEBI:33704	8140	Chemical	Gene	Incorporation|compound|START_ENTITY Role|nmod|Incorporation Role|nmod|END_ENTITY	Role of LAT1 in the Promotion of Amino_Acid Incorporation in Activated T Cells .
26024742	0	Amino_Acid	14,24	LAT1	39,43	Amino Acid	LAT1	D000596	8140	Chemical	Gene	Transporters|compound|START_ENTITY Expression|nmod|Transporters Expression|appos|END_ENTITY	Expression of Amino_Acid Transporters -LRB- LAT1 and ASCT2 -RRB- in Patients with Stage III/IV Laryngeal_Squamous_Cell_Carcinoma .
25950869	0	Amino_Acid	7,17	Myoglobin	42,51	Amino Acid	Myoglobin	D000596	4151	Chemical	Gene	Hydrolysis|compound|START_ENTITY Hydrolysis|nmod|END_ENTITY	Highly Amino_Acid Selective Hydrolysis of Myoglobin at Aspartate Residues as Promoted by Zirconium -LRB- IV -RRB- - Substituted Polyoxometalates .
26630841	0	Amino_Acid	31,41	Neuraminidase	17,30	Amino Acid	Neuraminidase	D000596	4758	Chemical	Gene	Sequences|compound|START_ENTITY Sequences|compound|END_ENTITY	-LSB- Analysis of the Neuraminidase Amino_Acid Sequences of Influenza A/H1N1pdm09 , A/H3N2 , and B Viruses Isolated from Influenza Patients in the 2013/14 Japanese Influenza Season -RSB- .
23633098	0	Amino_Acid	0,10	asparagine_synthetase	45,66	Amino Acid	asparagine synthetase	CHEBI:33704	692995(Tax:7091)	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Amino_Acid deprivation-induced expression of asparagine_synthetase regulates the growth and survival of cultured silkworm cells .
16711745	0	Amino_Acid	0,10	lysozyme	158,166	Amino Acid	lysozyme	CHEBI:33704	4069	Chemical	Gene	Autocorrelation|compound|START_ENTITY vectors|nsubj|Autocorrelation vectors|nmod|Networks Networks|nmod|prediction prediction|nmod|stability stability|nmod|mutants mutants|compound|END_ENTITY	Amino_Acid Sequence Autocorrelation vectors and ensembles of Bayesian-Regularized Genetic Neural Networks for prediction of conformational stability of human lysozyme mutants .
25295787	0	Amino_Acid	48,58	mTORC1	86,92	Amino Acid	mTORC1	CHEBI:33704	382056(Tax:10090)	Chemical	Gene	Pathway|compound|START_ENTITY Components|nmod|Pathway Components|nmod|END_ENTITY	Let-7 Coordinately Suppresses Components of the Amino_Acid Sensing Pathway to Repress mTORC1 and Induce Autophagy .
26279575	0	Amino_Acid	0,10	mTORC1	25,31	Amino Acid	mTORC1	D000596	382056(Tax:10090)	Chemical	Gene	Activation|compound|START_ENTITY Activation|nmod|END_ENTITY	Amino_Acid Activation of mTORC1 by a PB1-Domain-Driven Kinase Complex Cascade .
26389641	0	Amino_Acid	52,62	mTORC1	23,29	Amino Acid	mTORC1	D000596	382056(Tax:10090)	Chemical	Gene	Transporters|compound|START_ENTITY Activates|nmod|Transporters Activates|dobj|Pathway Pathway|amod|END_ENTITY	YAP1 and TAZ Activates mTORC1 Pathway by Regulating Amino_Acid Transporters in hepatocellular_carcinoma .
26389641	0	Amino_Acid	52,62	mTORC1	23,29	Amino Acid	mTORC1	D000596	382056(Tax:10090)	Chemical	Gene	Transporters|compound|START_ENTITY Activates|nmod|Transporters Activates|dobj|Pathway Pathway|amod|END_ENTITY	YAP1 and TAZ Activates mTORC1 Pathway by Regulating Amino_Acid Transporters in hepatocellular_carcinoma .
26608079	0	Amino_Acid	14,24	mTORC1	52,58	Amino Acid	mTORC1	D000596	382056(Tax:10090)	Chemical	Gene	Trafficking|compound|START_ENTITY Trafficking|nmod|END_ENTITY	Regulation of Amino_Acid Transporter Trafficking by mTORC1 in Primary Human Trophoblast cells is Mediated by the Ubiquitin Ligase Nedd4-2 .
25284312	0	Amino_Acids	38,49	EPO	75,78	Amino Acids	EPO	CHEBI:33709	2056	Chemical	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Structural Identification of Modified Amino_Acids on the Interface between EPO and Its Receptor from EPO BRP , Human Recombinant Erythropoietin by LC/MS Analysis .
25733201	0	Amino_Acids	40,51	Insulin	10,17	Amino Acids	Insulin	CHEBI:33709	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|Therapy Therapy|compound|END_ENTITY	Effect of Insulin Sensitizer Therapy on Amino_Acids and Their Metabolites .
27064245	0	Amino_Acids	0,11	Insulin	28,35	Amino Acids	Insulin	MESH:D000596	397415(Tax:9823)	Chemical	Gene	START_ENTITY|appos|Independent Independent|nmod|END_ENTITY	Amino_Acids , Independent of Insulin , Attenuate Skeletal Muscle Autophagy in Neonatal Pigs during Endotoxemia .
26112996	0	Amino_Acids	0,11	mTORC1	96,102	Amino Acids	mTORC1	CHEBI:33709	382056(Tax:10090)	Chemical	Gene	Action|compound|START_ENTITY Action|nmod|Pathway Pathway|compound|END_ENTITY	Amino_Acids Attenuate Insulin Action on Gluconeogenesis and Promote Fatty_Acid Biosynthesis via mTORC1 Signaling Pathway in trout Hepatocytes .
9814971	0	Amino_acid	0,10	4E-BP1	46,52	Amino acid	4E-BP1	CHEBI:33704	1978	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|END_ENTITY	Amino_acid effects on translational repressor 4E-BP1 are mediated primarily by L-leucine in isolated adipocytes .
3139002	0	Amino_acid	1,11	Ap1	37,40	Amino acid	Ap1	CHEBI:33704	3725	Chemical	Gene	sequence|compound|START_ENTITY sequence|nmod|END_ENTITY	-LSB- Amino_acid sequence of ribonuclease Ap1 from Aspergillus pallidus -RSB- .
2429957	0	Amino_acid	0,10	B23	63,66	Amino acid	B23	CHEBI:33704	4869	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of a specific antigenic peptide of protein B23 .
3277172	0	Amino_acid	0,10	BSC-1_cell_growth_inhibitor	27,54	Amino acid	BSC-1 cell growth inhibitor	CHEBI:33704	7042	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of the BSC-1_cell_growth_inhibitor -LRB- polyergin -RRB- deduced from the nucleotide sequence of the cDNA .
14500885	0	Amino_acid	0,10	BaP1	45,49	Amino acid	BaP1	CHEBI:33704	8314	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence and crystal structure of BaP1 , a metalloproteinase from Bothrops asper snake venom that exerts multiple tissue-damaging activities .
6477504	0	Amino_acid	0,10	C-reactive_protein	51,69	Amino acid	C-reactive protein	CHEBI:33704	1401	Chemical	Gene	homology|amod|START_ENTITY homology|nmod|END_ENTITY	Amino_acid sequence homology between rat and human C-reactive_protein .
6978711	0	Amino_acid	0,10	C4	92,94	Amino acid	C4	CHEBI:33704	720	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|nsubj|sequence	Amino_acid sequence around the thiol and reactive acyl groups of human complement component C4 .
4033666	0	Amino_acid	0,10	C4b-binding_protein	37,56	Amino acid	C4b-binding protein	CHEBI:33704	722	Chemical	Gene	studies|amod|START_ENTITY studies|nmod|END_ENTITY	Amino_acid sequence studies of human C4b-binding_protein : N-terminal sequence analysis and alignment of the fragments produced by limited proteolysis with chymotrypsin and the peptides produced by cyanogen_bromide treatment .
2226832	0	Amino_acid	0,10	CAP37	23,28	Amino acid	CAP37	CHEBI:33704	566	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of CAP37 , a human neutrophil granule-derived antibacterial and monocyte-specific chemotactic glycoprotein structurally similar to neutrophil elastase .
7969149	0	Amino_acid	0,10	CDC25	27,32	Amino acid	CDC25	CHEBI:33704	851019(Tax:4932)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Amino_acid residues in the CDC25 guanine_nucleotide exchange factor critical for interaction with Ras .
2464031	0	Amino_acid	0,10	CDR2	31,35	Amino acid	CDR2	CHEBI:33704	1039	Chemical	Gene	substitutions|amod|START_ENTITY substitutions|nmod|END_ENTITY	Amino_acid substitutions in VH CDR2 change the idiotype but not the antigen-binding of monoclonal antibodies to alpha -LRB- 1 -- 6 -RRB- dextrans .
2026880	0	Amino_acid	0,10	CDR3	43,47	Amino acid	CDR3	CHEBI:33704	110334(Tax:10090)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Amino_acid residues in the T cell receptor CDR3 determine the antigenic reactivity patterns of insulin-reactive hybridomas .
2517316	0	Amino_acid	0,10	CDR3	106,110	Amino acid	CDR3	CHEBI:33704	8163	Chemical	Gene	sequence|amod|START_ENTITY sequence|dep|presence presence|nmod|END_ENTITY	Amino_acid sequence of the variable domains of a human anti-Rh -LRB- c -RRB- antibody : presence of an unusually long CDR3 in the lambda chain .
22374137	0	Amino_acid	0,10	CO2	66,69	Amino acid	CO2	CHEBI:33704	717	Chemical	Gene	liquid-based|amod|START_ENTITY facilitated|nsubj|liquid-based facilitated|nmod|separation separation|compound|END_ENTITY	Amino_acid ionic liquid-based facilitated transport membranes for CO2 separation .
24399137	0	Amino_acid	0,10	COI1	56,60	Amino acid	COI1	CHEBI:33704	818581(Tax:3702)	Chemical	Gene	substitutions|amod|START_ENTITY substitutions|nmod|END_ENTITY	Amino_acid substitutions of GLY98 , LEU245 and GLU543 in COI1 distinctively affect jasmonate-regulated male fertility in Arabidopsis .
1974522	0	Amino_acid	0,10	Ca2	27,30	Amino acid	Ca2	CHEBI:33704	760	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of the Ca2 -LRB- + -RRB- - triggered luciferin binding protein of Renilla reniformis .
114209	0	Amino_acid	0,10	Dob	99,102	Amino acid	Dob	CHEBI:33704	3112	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of the heavy-chain variable region of the crystallizable human myeloma protein Dob .
1946388	0	Amino_acid	0,10	Fel_dI	23,29	Amino acid	Fel dI	CHEBI:33704	677879(Tax:9685)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of Fel_dI , the major allergen of the domestic_cat : protein sequence analysis and cDNA cloning .
1588320	0	Amino_acid	0,10	HA1	41,44	Amino acid	HA1	CHEBI:33704	23526	Chemical	Gene	identity|amod|START_ENTITY identity|nmod|END_ENTITY	Amino_acid sequence identity between the HA1 of influenza_A _ -LRB- H3N2 -RRB- _ viruses grown in mammalian and primary chick kidney cells .
12036971	0	Amino_acid	0,10	HLA-DRB	38,45	Amino acid	HLA-DRB	CHEBI:33704	3125	Chemical	Gene	residue|amod|START_ENTITY residue|nmod|END_ENTITY	Amino_acid residue 67 -LRB- isoleucine -RRB- of HLA-DRB is associated with POHS .
22841961	0	Amino_acid	0,10	LcrV	28,32	Amino acid	LcrV	CHEBI:33704	1149310(Tax:187410)	Chemical	Gene	substitutions|amod|START_ENTITY substitutions|nmod|END_ENTITY	Amino_acid substitutions in LcrV at putative sites of interaction with Toll-like receptor 2 do not affect the virulence of Yersinia_pestis .
2421265	0	Amino_acid	0,10	MCD_peptide	33,44	Amino acid	MCD peptide	CHEBI:33704	406134(Tax:7460)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of bumblebee MCD_peptide : a new mast_cell_degranulating peptide from the venom of the bumblebee Megabombus pennsylvanicus .
7981232	0	Amino_acid	0,10	NBL-1	88,93	Amino acid	NBL-1	CHEBI:33704	535280(Tax:9913)	Chemical	Gene	response|amod|START_ENTITY response|nmod|END_ENTITY	Amino_acid deprivation-induced stress response in the bovine renal epithelial cell line NBL-1 : induction of HSP 70 by phenylalanine .
2962637	0	Amino_acid	0,10	P-57	23,27	Amino acid	P-57	CHEBI:33704	12721(Tax:10090)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of P-57 , a neurospecific calmodulin-binding protein .
25031333	0	Amino_acid	0,10	PB1	28,31	Amino acid	PB1	CHEBI:33704	396074(Tax:9031)	Chemical	Gene	substitutions|amod|START_ENTITY substitutions|nmod|END_ENTITY	Amino_acid substitutions in PB1 of avian influenza viruses influence pathogenicity and transmissibility in chickens .
1765098	0	Amino_acid	0,10	PR-39	23,28	Amino acid	PR-39	CHEBI:33704	407610(Tax:9823)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of PR-39 .
7459340	0	Amino_acid	0,10	Ra3	40,43	Amino acid	Ra3	CHEBI:33704	474223	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of ragweed allergen Ra3 .
1331063	0	Amino_acid	0,10	Rab3A	43,48	Amino acid	Rab3A	CHEBI:33704	5864	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Amino_acid residues in the Ras-like GTPase Rab3A that specify sensitivity to factors that regulate the GTP/GDP cycling of Rab3A .
17028591	0	Amino_acid	0,10	Rag1	23,27	Amino acid	Rag1	CHEBI:33704	5896	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Amino_acid residues in Rag1 crucial for DNA hairpin formation .
3027698	0	Amino_acid	0,10	S-adenosyl-L-homocysteine_hydrolase	23,58	Amino acid	S-adenosyl-L-homocysteine hydrolase	CHEBI:33704	29443(Tax:10116)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of S-adenosyl-L-homocysteine_hydrolase from rat liver as derived from the cDNA sequence .
8769108	0	Amino_acid	0,10	S100A12	43,50	Amino acid	S100A12	CHEBI:33704	6283	Chemical	Gene	determination|amod|START_ENTITY determination|nmod|END_ENTITY	Amino_acid sequence determination of human S100A12 -LRB- P6 , calgranulin_C , CGRP , CAAF1 -RRB- by tandem mass spectrometry .
16621798	0	Amino_acid	0,10	SNAT2	34,39	Amino acid	SNAT2	CHEBI:33704	54407	Chemical	Gene	starvation|amod|START_ENTITY induces|nsubj|starvation induces|dobj|transporter transporter|amod|END_ENTITY	Amino_acid starvation induces the SNAT2 neutral amino_acid transporter by a mechanism that involves eukaryotic initiation factor 2alpha phosphorylation and cap-independent translation .
18765678	0	Amino_acid	0,10	TOR	25,28	Amino acid	TOR	CHEBI:33704	21977(Tax:10090)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Amino_acid regulation of TOR complex 1 .
11514627	0	Amino_acid	0,10	Tpr	48,51	Amino acid	Tpr	CHEBI:33704	7175	Chemical	Gene	substitutions|amod|START_ENTITY substitutions|nmod|END_ENTITY	Amino_acid substitutions of coiled-coil protein Tpr abrogate anchorage to the nuclear_pore_complex but not parallel , in-register homodimerization .
3032834	0	Amino_acid	0,10	UP1	23,26	Amino acid	UP1	CHEBI:33704	505093(Tax:9913)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of UP1 , an hnRNP-derived single-stranded nucleic acid binding protein from calf thymus .
17598093	0	Amino_acid	0,10	VIAAT	24,29	Amino acid	VIAAT	CHEBI:33704	83612(Tax:10116)	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Amino_acid transporter -LRB- VIAAT , VGLUT2 -RRB- and chloride cotransporter -LRB- KCC1 , KCC2 and NKCC1 -RRB- expression in the vestibular nuclei of intact and labyrinthectomized rat .
2342988	0	Amino_acid	0,10	VIP	23,26	Amino acid	VIP	CHEBI:33704	100352512(Tax:9986)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of VIP , PHI and secretin from the rabbit small intestine .
7499437	0	Amino_acid	0,10	VP16	68,72	Amino acid	VP16	CHEBI:33704	3054	Chemical	Gene	substitutions|amod|START_ENTITY substitutions|nmod|END_ENTITY	Amino_acid substitutions in the herpes simplex virus transactivator VP16 uncouple direct protein-protein interaction and DNA binding from complex assembly and transactivation .
12967660	0	Amino_acid	0,10	Xrs2p	22,27	Amino acid	Xrs2p	CHEBI:33704	851975(Tax:4932)	Chemical	Gene	changes|amod|START_ENTITY changes|nmod|END_ENTITY	Amino_acid changes in Xrs2p , Dun1p , and Rfa2p that remove the preferred targets of the ATM family of protein kinases do not affect DNA repair or telomere length in Saccharomyces_cerevisiae .
8182597	0	Amino_acid	0,10	ZP4	61,64	Amino acid	ZP4	CHEBI:33704	664793(Tax:10090)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of a porcine zona pellucida glycoprotein ZP4 determined by peptide mapping and cDNA cloning .
3778488	0	Amino_acid	0,10	acidic_fibroblast_growth_factor	29,60	Amino acid	acidic fibroblast growth factor	CHEBI:33704	2246	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of human acidic_fibroblast_growth_factor .
3918528	0	Amino_acid	0,10	aldolase	43,51	Amino acid	aldolase	CHEBI:33704	43183(Tax:7227)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of an invertebrate FBP aldolase -LRB- from Drosophila_melanogaster -RRB- .
2706274	0	Amino_acid	0,10	alpha-chain	23,34	Amino acid	alpha-chain	CHEBI:33704	2217	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of alpha-chain of hemoglobin IV from trout -LRB- Salmo_irideus -RRB- .
6955253	2	Amino_acid	85,95	alpha-chain	143,154	Amino acid	alpha-chain	CHEBI:33704	2217	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of the N-terminal 179 residues of the alpha-chain of an HLA-Dw2 / DR2 alloantigen -LRB- author 's transl -RRB- -RSB- .
8598459	0	Amino_acid	0,10	alpha-chain	32,43	Amino acid	alpha-chain	CHEBI:33704	2217	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Amino_acid residues on the I-Ak alpha-chain required for the binding and stability of two antigenic peptides .
962723	1	Amino_acid	59,69	alpha-chain	86,97	Amino acid	alpha-chain	CHEBI:33704	2217	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of the alpha-chain .
6157681	0	Amino_acid	0,10	alpha-fetoprotein	41,58	Amino acid	alpha-fetoprotein	CHEBI:33704	24177(Tax:10116)	Chemical	Gene	homology|amod|START_ENTITY homology|nmod|END_ENTITY	Amino_acid sequence homology between rat alpha-fetoprotein and albumin at the COOH-terminal regions .
8925936	0	Amino_acid	0,10	alpha-lactalbumin	53,70	Amino acid	alpha-lactalbumin	CHEBI:33704	281894(Tax:9913)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence and crystal structure of buffalo alpha-lactalbumin .
6556193	0	Amino_acid	0,10	alpha_1-antichymotrypsin	50,74	Amino acid	alpha 1-antichymotrypsin	CHEBI:33704	12	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence at the reactive site of human alpha_1-antichymotrypsin .
3458201	0	Amino_acid	0,10	alpha_1B-glycoprotein	36,57	Amino acid	alpha 1B-glycoprotein	CHEBI:33704	1	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of human plasma alpha_1B-glycoprotein : homology to the immunoglobulin supergene family .
2134072	0	Amino_acid	0,10	angiotensin_II	68,82	Amino acid	angiotensin II	CHEBI:33704	183	Chemical	Gene	determination|amod|START_ENTITY determination|nmod|END_ENTITY	Amino_acid sequence determination of three monoclonal antibodies to angiotensin_II .
6928653	0	Amino_acid	0,10	angiotensin_II	38,52	Amino acid	angiotensin II	CHEBI:33704	183	Chemical	Gene	conformation|amod|START_ENTITY conformation|nmod|END_ENTITY	Amino_acid side chain conformation in angiotensin_II and analogs : correlated results of circular dichroism and 1H nuclear magnetic resonance .
7992240	0	Amino_acid	0,10	antithrombin	52,64	Amino acid	antithrombin	CHEBI:33704	462	Chemical	Gene	substitutions|amod|START_ENTITY substitutions|nmod|residue residue|nmod|END_ENTITY	Amino_acid substitutions of the P2 residue of human antithrombin that either enhance or impair function .
7896748	0	Amino_acid	0,10	antithrombin_III	31,47	Amino acid	antithrombin III	CHEBI:33704	462	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of porcine antithrombin_III .
2010688	0	Amino_acid	0,10	apolipoprotein_E	30,46	Amino acid	apolipoprotein E	CHEBI:33704	100009337(Tax:9986)	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|nsubj|sequence	Amino_acid sequence of rabbit apolipoprotein_E .
2834354	0	Amino_acid	0,10	argininosuccinate_lyase	27,50	Amino acid	argininosuccinate lyase	CHEBI:33704	59085(Tax:10116)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of rat argininosuccinate_lyase deduced from cDNA .
15385533	0	Amino_acid	0,10	asparagine_synthetase	67,88	Amino acid	asparagine synthetase	CHEBI:33704	440	Chemical	Gene	deprivation|amod|START_ENTITY induces|nsubj|deprivation induces|dobj|rate rate|nmod|gene gene|compound|END_ENTITY	Amino_acid deprivation induces the transcription rate of the human asparagine_synthetase gene through a timed program of expression and promoter binding of nutrient-responsive basic region/leucine zipper transcription factors as well as localized histone acetylation .
2529857	0	Amino_acid	0,10	atrial_natriuretic_peptide	60,86	Amino acid	atrial natriuretic peptide	CHEBI:33704	4878	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|nsubj|sequence	Amino_acid sequence and relative biological activity of eel atrial_natriuretic_peptide .
1637296	0	Amino_acid	0,10	band-3	23,29	Amino acid	band-3	CHEBI:33704	100136769(Tax:8022)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|protein protein|amod|END_ENTITY	Amino_acid sequence of band-3 protein from rainbow_trout erythrocytes derived from cDNA .
1091637	0	Amino_acid	0,10	beta-galactosidase	23,41	Amino acid	beta-galactosidase	CHEBI:33704	2720	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of beta-galactosidase .
149795	0	Amino_acid	0,10	beta-galactosidase	23,41	Amino acid	beta-galactosidase	CHEBI:33704	2720	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of beta-galactosidase .
97293	0	Amino_acid	0,10	beta-galactosidase	23,41	Amino acid	beta-galactosidase	CHEBI:33704	2720	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of beta-galactosidase .
97294	0	Amino_acid	0,10	beta-galactosidase	23,41	Amino acid	beta-galactosidase	CHEBI:33704	2720	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of beta-galactosidase .
97295	0	Amino_acid	0,10	beta-galactosidase	23,41	Amino acid	beta-galactosidase	CHEBI:33704	2720	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of beta-galactosidase .
97296	0	Amino_acid	0,10	beta-galactosidase	23,41	Amino acid	beta-galactosidase	CHEBI:33704	2720	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of beta-galactosidase .
97297	0	Amino_acid	0,10	beta-galactosidase	23,41	Amino acid	beta-galactosidase	CHEBI:33704	2720	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of beta-galactosidase .
97298	0	Amino_acid	0,10	beta-galactosidase	23,41	Amino acid	beta-galactosidase	CHEBI:33704	2720	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of beta-galactosidase .
3391173	0	Amino_acid	0,10	calcium-binding_protein	25,48	Amino acid	calcium-binding protein	CHEBI:33704	1068	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of a calcium-binding_protein -LRB- TCBP-10 -RRB- from Tetrahymena .
4086472	0	Amino_acid	0,10	calmodulin	23,33	Amino acid	calmodulin	CHEBI:33704	100682497	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of calmodulin from wheat germ .
416851	0	Amino_acid	0,10	carbonic_anhydrase_II	30,51	Amino acid	carbonic anhydrase II	CHEBI:33704	100009156(Tax:9986)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of rabbit carbonic_anhydrase_II .
3042023	0	Amino_acid	0,10	cardiac_troponin_I	30,48	Amino acid	cardiac troponin I	CHEBI:33704	511094(Tax:9913)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of bovine cardiac_troponin_I .
3379063	0	Amino_acid	0,10	cathepsin_B	37,48	Amino acid	cathepsin B	CHEBI:33704	281105(Tax:9913)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of bovine spleen cathepsin_B .
3972105	0	Amino_acid	0,10	cathepsin_B	35,46	Amino acid	cathepsin B	CHEBI:33704	1508	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of human liver cathepsin_B .
6406481	0	Amino_acid	0,10	cathepsin_D	38,49	Amino acid	cathepsin D	CHEBI:33704	13033(Tax:10090)	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|nsubj|sequence	Amino_acid sequence of porcine spleen cathepsin_D light chain .
6587385	0	Amino_acid	0,10	cathepsin_D	38,49	Amino acid	cathepsin D	CHEBI:33704	1509	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|nsubj|sequence	Amino_acid sequence of porcine spleen cathepsin_D .
3305012	0	Amino_acid	0,10	cathepsin_L	37,48	Amino acid	cathepsin L	CHEBI:33704	427466(Tax:9031)	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|nsubj|sequence	Amino_acid sequence of chicken liver cathepsin_L .
3402618	0	Amino_acid	0,10	cathepsin_L	33,44	Amino acid	cathepsin L	CHEBI:33704	25697(Tax:10116)	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|nsubj|sequence	Amino_acid sequence of rat liver cathepsin_L .
3298238	1	Amino_acid	52,62	chorionic_gonadotropin_beta-subunit	82,117	Amino acid	chorionic gonadotropin beta-subunit	CHEBI:33704	1082	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of equine chorionic_gonadotropin_beta-subunit .
7295770	0	Amino_acid	0,10	colipase_B	29,39	Amino acid	colipase B	CHEBI:33704	100053646(Tax:9796)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of horse colipase_B .
6342610	0	Amino_acid	0,10	complement_Factor_B	44,63	Amino acid	complement Factor B	CHEBI:33704	629	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of the Bb fragment from complement_Factor_B .
7354043	0	Amino_acid	0,10	cytochrome_b5	62,75	Amino acid	cytochrome b5	CHEBI:33704	100328915(Tax:9986)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of the membranous segment of rabbit liver cytochrome_b5 .
2853705	0	Amino_acid	0,10	cytochrome_c	40,52	Amino acid	cytochrome c	CHEBI:33704	54205	Chemical	Gene	studies|amod|START_ENTITY studies|nmod|END_ENTITY	Amino_acid replacement studies of human cytochrome_c by a complementation system using CYC1 deficient yeast .
4954366	0	Amino_acid	0,10	cytochrome_c	43,55	Amino acid	cytochrome c	CHEBI:33704	106992390	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of rhesus_monkey heart cytochrome_c .
5835940	0	Amino_acid	0,10	cytochrome_c	41,53	Amino acid	cytochrome c	CHEBI:33704	54205	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of rattlesnake heart cytochrome_c .
5922971	0	Amino_acid	0,10	cytochrome_c	35,47	Amino acid	cytochrome c	CHEBI:33704	54205	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of whale heart cytochrome_c .
5918308	0	Amino_acid	0,10	elastin	39,46	Amino acid	elastin	CHEBI:33704	2006	Chemical	Gene	composition|amod|START_ENTITY composition|nmod|END_ENTITY	Amino_acid composition of human aortic elastin as influenced by age .
6029924	0	Amino_acid	0,10	elastin	26,33	Amino acid	elastin	CHEBI:33704	2006	Chemical	Gene	composition|amod|START_ENTITY composition|nmod|END_ENTITY	Amino_acid composition of elastin in the developing human aorta .
7226529	0	Amino_acid	0,10	elastin	23,30	Amino acid	elastin	CHEBI:33704	2006	Chemical	Gene	analysis|amod|START_ENTITY analysis|nmod|hydrolysates hydrolysates|compound|END_ENTITY	Amino_acid analysis of elastin hydrolysates using a lithium_citrate gradient : quantification of elastin from whole lung .
7226529	0	Amino_acid	0,10	elastin	96,103	Amino acid	elastin	CHEBI:33704	2006	Chemical	Gene	analysis|amod|START_ENTITY analysis|dep|quantification quantification|nmod|END_ENTITY	Amino_acid analysis of elastin hydrolysates using a lithium_citrate gradient : quantification of elastin from whole lung .
7387627	0	Amino_acid	0,10	elastin	61,68	Amino acid	elastin	CHEBI:33704	280781(Tax:9913)	Chemical	Gene	sequences|nsubj|START_ENTITY sequences|nmod|cross-links cross-links|nmod|END_ENTITY	Amino_acid sequences C-terminal to the cross-links in bovine elastin .
3014523	0	Amino_acid	0,10	elongation_factor_2	33,52	Amino acid	elongation factor 2	CHEBI:33704	1938	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of mammalian elongation_factor_2 deduced from the cDNA sequence : homology with GTP-binding proteins .
3264556	0	Amino_acid	0,10	entactin	44,52	Amino acid	entactin	CHEBI:33704	18073(Tax:10090)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence and domain structure of entactin .
4084317	0	Amino_acid	0,10	epidermal_thiol_proteinase_inhibitor	50,86	Amino acid	epidermal thiol proteinase inhibitor	CHEBI:33704	288075(Tax:10116)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of derivatives of newborn rat epidermal_thiol_proteinase_inhibitor .
11997044	0	Amino_acid	0,10	erythropoietin	35,49	Amino acid	erythropoietin	CHEBI:33704	2056	Chemical	Gene	268-276|compound|START_ENTITY 268-276|nmod|receptor receptor|compound|END_ENTITY	Amino_acid residues 268-276 of the erythropoietin receptor contain an endocytosis motif and are required for erythropoietin-mediated proliferation .
16937399	0	Amino_acid	0,10	erythropoietin	78,92	Amino acid	erythropoietin	CHEBI:33704	2056	Chemical	Gene	supplementation|amod|START_ENTITY modulates|nsubj|supplementation modulates|dobj|state state|nmod|END_ENTITY	Amino_acid and manganese supplementation modulates the glycosylation state of erythropoietin in a CHO culture system .
123758	0	Amino_acid	0,10	fibrinogen	66,76	Amino acid	fibrinogen	CHEBI:33704	2244	Chemical	Gene	studies|amod|START_ENTITY studies|nmod|fragments fragments|nmod|END_ENTITY	Amino_acid sequence studies on plasmin-derived fragments of human fibrinogen : amino-terminal sequences of intermediate and terminal fragments .
139916	0	Amino_acid	0,10	fibrinogen	56,66	Amino acid	fibrinogen	CHEBI:33704	2244	Chemical	Gene	studies|amod|START_ENTITY studies|nmod|END_ENTITY	Amino_acid sequence studies on the alpha chain of human fibrinogen .
2722830	0	Amino_acid	0,10	fibrinogen	24,34	Amino acid	fibrinogen	CHEBI:33704	2244	Chemical	Gene	sequences|nsubj|START_ENTITY sequences|nmod|END_ENTITY	Amino_acid sequences in fibrinogen mediating its interaction with its platelet receptor , GPIIbIIIa .
273904	0	Amino_acid	0,10	fibrinogen	47,57	Amino acid	fibrinogen	CHEBI:33704	2244	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|chain chain|nmod|END_ENTITY	Amino_acid sequence of the beta chain of human fibrinogen : homology with the gamma chain .
420779	0	Amino_acid	0,10	fibrinogen	47,57	Amino acid	fibrinogen	CHEBI:33704	2244	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of the beta chain of human fibrinogen .
518844	0	Amino_acid	0,10	fibrinogen	56,66	Amino acid	fibrinogen	CHEBI:33704	2244	Chemical	Gene	studies|amod|START_ENTITY studies|nmod|END_ENTITY	Amino_acid sequence studies on the alpha chain of human fibrinogen .
518845	0	Amino_acid	0,10	fibrinogen	56,66	Amino acid	fibrinogen	CHEBI:33704	2244	Chemical	Gene	studies|amod|START_ENTITY studies|nmod|END_ENTITY	Amino_acid sequence studies on the alpha chain of human fibrinogen .
518846	0	Amino_acid	0,10	fibrinogen	56,66	Amino acid	fibrinogen	CHEBI:33704	2244	Chemical	Gene	studies|amod|START_ENTITY studies|nmod|END_ENTITY	Amino_acid sequence studies on the alpha chain of human fibrinogen .
6056635	0	Amino_acid	0,10	fibrinogen	32,42	Amino acid	fibrinogen	CHEBI:33704	2244	Chemical	Gene	composition|amod|START_ENTITY composition|nmod|END_ENTITY	Amino_acid composition of human fibrinogen and anticoagulant derivatives .
826275	0	Amino_acid	0,10	fibrinogen	57,67	Amino acid	fibrinogen	CHEBI:33704	2244	Chemical	Gene	compositions|amod|START_ENTITY compositions|nmod|END_ENTITY	Amino_acid compositions of the subunit chains of lamprey fibrinogen .
851527	0	Amino_acid	0,10	fibrinogen	56,66	Amino acid	fibrinogen	CHEBI:33704	2244	Chemical	Gene	studies|amod|START_ENTITY studies|nmod|END_ENTITY	Amino_acid sequence studies on the alpha chain of human fibrinogen .
814119	0	Amino_acid	0,10	flagellin	23,32	Amino acid	flagellin	CHEBI:33704	936664(Tax:224308)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of flagellin of Bacillus_subtilis_168 .
814120	0	Amino_acid	0,10	flagellin	23,32	Amino acid	flagellin	CHEBI:33704	936664(Tax:224308)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of flagellin of Bacillus_subtilis_168 .
814121	0	Amino_acid	0,10	flagellin	23,32	Amino acid	flagellin	CHEBI:33704	936664(Tax:224308)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of flagellin of Bacillus_subtilis_168 .
3377794	0	Amino_acid	0,10	fumarase	37,45	Amino acid	fumarase	CHEBI:33704	2271	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|nsubj|sequence	Amino_acid sequence of porcine heart fumarase .
1967255	0	Amino_acid	0,10	gamma-glutamylcysteine_synthetase	34,67	Amino acid	gamma-glutamylcysteine synthetase	CHEBI:33704	25283(Tax:10116)	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|nsubj|sequence	Amino_acid sequence of rat kidney gamma-glutamylcysteine_synthetase .
8104188	0	Amino_acid	0,10	gamma-glutamylcysteine_synthetase	68,101	Amino acid	gamma-glutamylcysteine synthetase	CHEBI:33704	25283(Tax:10116)	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|nsubj|sequence	Amino_acid sequence and function of the light subunit of rat kidney gamma-glutamylcysteine_synthetase .
6696761	0	Amino_acid	0,10	glucose-6-phosphate_dehydrogenase	69,102	Amino acid	glucose-6-phosphate dehydrogenase	CHEBI:33704	2539	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of the carboxy-terminal end of human erythrocyte glucose-6-phosphate_dehydrogenase .
8138540	0	Amino_acid	0,10	glutathione_S-transferase_a	23,50	Amino acid	glutathione S-transferase a	CHEBI:33704	100379542(Tax:10141)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of glutathione_S-transferase_a from guinea_pig liver .
2332413	0	Amino_acid	0,10	glutathione_S-transferase_b	23,50	Amino acid	glutathione S-transferase b	CHEBI:33704	100731896	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of glutathione_S-transferase_b from guinea_pig liver .
7862666	0	Amino_acid	0,10	glutathione_synthetase	34,56	Amino acid	glutathione synthetase	CHEBI:33704	25458(Tax:10116)	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|nsubj|sequence	Amino_acid sequence of rat kidney glutathione_synthetase .
1382339	0	Amino_acid	0,10	gp120	63,68	Amino acid	gp120	CHEBI:33704	155971(Tax:11676)	Chemical	Gene	residues|amod|START_ENTITY type|nsubj|residues type|xcomp|critical critical|dep|END_ENTITY	Amino_acid residues of the human immunodeficiency virus type I gp120 critical for the binding of rat and human neutralizing antibodies that block the gp120-sCD4 interaction .
7515973	0	Amino_acid	0,10	gp120	68,73	Amino acid	gp120	CHEBI:33704	3700	Chemical	Gene	substitutions|amod|START_ENTITY substitutions|nmod|loop loop|amod|END_ENTITY	Amino_acid substitutions in the human_immunodeficiency_virus_type_1 gp120 V3 loop that change viral tropism also alter physical and functional properties of the virion envelope .
18990596	0	Amino_acid	0,10	growth_hormone	35,49	Amino acid	growth hormone	CHEBI:33704	2688	Chemical	Gene	profiles|amod|START_ENTITY profiles|nmod|therapy therapy|amod|END_ENTITY	Amino_acid profiles in adults with growth_hormone -LRB- GH -RRB- deficiency before and during GH replacement therapy .
6240911	0	Amino_acid	0,10	growth_hormone	59,73	Amino acid	growth hormone	CHEBI:33704	102537102	Chemical	Gene	sequences|nsubj|START_ENTITY sequences|nmod|residues residues|nmod|END_ENTITY	Amino_acid sequences around the cystine residues in alpaca growth_hormone .
7539887	0	Amino_acid	0,10	growth_hormone	48,62	Amino acid	growth hormone	CHEBI:33704	14599(Tax:10090)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|alpha-helix alpha-helix|nmod|END_ENTITY	Amino_acid residues in the third alpha-helix of growth_hormone involved in growth promoting activity .
1429498	0	Amino_acid	0,10	haptoglobin	60,71	Amino acid	haptoglobin	CHEBI:33704	3240	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence and disulfide-bridge location of canine haptoglobin .
7213810	0	Amino_acid	0,10	heart_aconitase	81,96	Amino acid	heart aconitase	CHEBI:33704	396999(Tax:9823)	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|nsubj|sequence	Amino_acid sequence of a peptide containing an essential cysteine residue of pig heart_aconitase .
3024703	0	Amino_acid	0,10	heat_shock_protein	33,51	Amino acid	heat shock protein	CHEBI:33704	374163(Tax:9031)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of a chicken heat_shock_protein derived from the complementary DNA nucleotide sequence .
6510521	0	Amino_acid	0,10	hemopexin	54,63	Amino acid	hemopexin	CHEBI:33704	3263	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of the N-terminal region of human hemopexin .
2229039	0	Amino_acid	0,10	heparin-binding_neurite-promoting_factor	46,86	Amino acid	heparin-binding neurite-promoting factor	CHEBI:33704	280904(Tax:9913)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence and characterization of a heparin-binding_neurite-promoting_factor -LRB- p18 -RRB- from bovine brain .
10209287	0	Amino_acid	0,10	heparin_cofactor_II	23,42	Amino acid	heparin cofactor II	CHEBI:33704	3053	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Amino_acid residues of heparin_cofactor_II required for stimulation of thrombin inhibition by sulphated polyanions .
3011081	0	Amino_acid	0,10	histidine-rich_glycoprotein	29,56	Amino acid	histidine-rich glycoprotein	CHEBI:33704	3273	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of human histidine-rich_glycoprotein derived from the nucleotide sequence of its cDNA .
12610012	0	Amino_acid	0,10	insulin	39,46	Amino acid	insulin	CHEBI:33704	3630	Chemical	Gene	ingestion|amod|START_ENTITY enhances|nsubj|ingestion enhances|dobj|secretion secretion|compound|END_ENTITY	Amino_acid ingestion strongly enhances insulin secretion in patients with long-term type 2 diabetes .
17956307	0	Amino_acid	0,10	insulin	23,30	Amino acid	insulin	CHEBI:33704	3630	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|appos|secretion secretion|compound|END_ENTITY	Amino_acid metabolism , insulin secretion and diabetes .
2192710	0	Amino_acid	0,10	insulin	52,59	Amino acid	insulin	CHEBI:33704	3630	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence from degu islet amyloid-derived insulin shows unique sequence characteristics .
23416304	0	Amino_acid	0,10	insulin	53,60	Amino acid	insulin	CHEBI:33704	280829(Tax:9913)	Chemical	Gene	determinants|amod|START_ENTITY determinants|nmod|self-assembly self-assembly|nmod|superstructures superstructures|compound|END_ENTITY	Amino_acid sequence determinants in self-assembly of insulin chiral amyloid superstructures : role of C-terminus of B-chain in association of fibrils .
2644251	0	Amino_acid	0,10	insulin	25,32	Amino acid	insulin	CHEBI:33704	3630	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|action action|compound|END_ENTITY	Amino_acid regulation of insulin action in isolated adipocytes .
3314270	0	Amino_acid	1,11	insulin	28,35	Amino acid	insulin	CHEBI:33704	483665(Tax:9615)	Chemical	Gene	sequence|compound|START_ENTITY sequence|nmod|END_ENTITY	-LSB- Amino_acid sequence of the insulin of the dog salmon Oncorhynchus_keta -RSB- .
875735	0	Amino_acid	0,10	insulin	41,48	Amino acid	insulin	CHEBI:33704	3630	Chemical	Gene	modulation|amod|START_ENTITY modulation|nmod|END_ENTITY	Amino_acid modulation of glucose-induced insulin and glucagon release in diabetic patients .
10694377	0	Amino_acid	0,10	insulin-like_growth_factor-binding_protein-1	51,95	Amino acid	insulin-like growth factor-binding protein-1	CHEBI:33704	25685(Tax:10116)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Amino_acid regulation of gene transcription of rat insulin-like_growth_factor-binding_protein-1 .
6333684	0	Amino_acid	0,10	interleukin_2	65,78	Amino acid	interleukin 2	CHEBI:33704	3558	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence and post-translational modification of human interleukin_2 .
6954534	0	Amino_acid	0,10	lipoamide_dehydrogenase	47,70	Amino acid	lipoamide dehydrogenase	CHEBI:33704	1738	Chemical	Gene	homology|amod|START_ENTITY homology|nmod|END_ENTITY	Amino_acid sequence homology between pig heart lipoamide_dehydrogenase and human erythrocyte glutathione_reductase .
19999712	0	Amino_acid	0,10	lupin	44,49	Amino acid	lupin	CHEBI:33704	51251	Chemical	Gene	composition|amod|START_ENTITY composition|nmod|END_ENTITY	Amino_acid composition and relationships of lupin and serradella leghaemoglobins .
16453632	0	Amino_acid	0,10	lysozyme	33,41	Amino acid	lysozyme	CHEBI:33704	693015(Tax:7091)	Chemical	Gene	sequences|compound|START_ENTITY sequences|nmod|END_ENTITY	Amino_acid and cDNA sequences of lysozyme from Hyalophora cecropia .
6412475	1	Amino_acid	47,57	lysozyme	73,81	Amino acid	lysozyme	CHEBI:33704	4069	Chemical	Gene	composition|amod|START_ENTITY composition|nmod|END_ENTITY	Amino_acid composition of lysozyme , ribonuclease and insulin after dry heating .
89864	0	Amino_acid	0,10	lysozyme	40,48	Amino acid	lysozyme	CHEBI:33704	4069	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|nsubj|sequence	Amino_acid sequence of California quail lysozyme .
6470012	2	Amino_acid	36,46	lysozyme_2	63,73	Amino acid	lysozyme 2	CHEBI:33704	280849(Tax:9913)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of cow lysozyme_2 and immunological comparisons with other lysozymes .
3469651	0	Amino_acid	0,10	mRNA_cap-binding_protein	27,51	Amino acid	mRNA cap-binding protein	CHEBI:33704	13684(Tax:10090)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of the mRNA_cap-binding_protein from human tissues .
21284988	0	Amino_acid	0,10	mTOR	24,28	Amino acid	mTOR	CHEBI:33704	21977(Tax:10090)	Chemical	Gene	START_ENTITY|acl|signaling signaling|xcomp|END_ENTITY	Amino_acid signaling to mTOR mediated by inositol_polyphosphate multikinase .
22342805	0	Amino_acid	0,10	mTORC1	37,43	Amino acid	mTORC1	CHEBI:33704	382056(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|sensing sensing|nmod|END_ENTITY	Amino_acid sensing and regulation of mTORC1 .
25963655	0	Amino_acid	0,10	mTORC1	21,27	Amino acid	mTORC1	D000596	382056(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|regulation regulation|amod|END_ENTITY	Amino_acid dependent mTORC1 regulation by the lysosomal membrane protein SLC38A9 .
15605414	0	Amino_acid	0,10	mammalian_target_of_rapamycin	33,62	Amino acid	mammalian target of rapamycin	CHEBI:33704	2475	Chemical	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Amino_acid signaling through the mammalian_target_of_rapamycin -LRB- mTOR -RRB- pathway : Role of glutamine and of cell shrinkage .
3122823	0	Amino_acid	0,10	mast_cell_protease_I	27,47	Amino acid	mast cell protease I	CHEBI:33704	100360872	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of rat mast_cell_protease_I -LRB- chymase -RRB- .
10473142	0	Amino_acid	0,10	msr/apj	48,55	Amino acid	msr/apj	CHEBI:33704	23796(Tax:10090)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence and embryonic expression of msr/apj , the mouse homolog of Xenopus X-msr and human APJ .
2578056	0	Amino_acid	0,10	myelin_basic_protein	31,51	Amino acid	myelin basic protein	CHEBI:33704	618684(Tax:9913)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of porcine myelin_basic_protein .
2340078	0	Amino_acid	0,10	myoglobin	23,32	Amino acid	myoglobin	CHEBI:33704	4151	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of myoglobin from the mollusc Bursatella leachii .
25794748	0	Amino_acid	0,10	myoglobin	102,111	Amino acid	myoglobin	CHEBI:33704	418056(Tax:9031)	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|nsubj|sequence	Amino_acid sequence of Japanese_quail -LRB- Coturnix_japonica -RRB- and northern bobwhite -LRB- Colinus virginianus -RRB- myoglobin .
2675985	0	Amino_acid	1,11	myoglobin	32,41	Amino acid	myoglobin	CHEBI:33704	59108(Tax:10116)	Chemical	Gene	sequence|compound|START_ENTITY sequence|nmod|END_ENTITY	-LSB- Amino_acid sequence of Ondatra myoglobin -LRB- Ondatra zibethica -RRB- .
3949784	0	Amino_acid	0,10	myoglobin	23,32	Amino acid	myoglobin	CHEBI:33704	102975021	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of myoglobin from the mollusc Dolabella auricularia .
6260792	0	Amino_acid	0,10	myoglobin	25,34	Amino acid	myoglobin	CHEBI:33704	4151	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of a myoglobin from lace monitor lizard , Varanus varius , and its evolutionary implications .
6783658	0	Amino_acid	0,10	myoglobin	25,34	Amino acid	myoglobin	CHEBI:33704	4151	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of a myoglobin isolated from map turtle , Graptemys geographica .
6849938	0	Amino_acid	0,10	myoglobin	31,40	Amino acid	myoglobin	CHEBI:33704	4151	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of dimeric myoglobin from Cerithidea rhizophorarum .
7259634	1	Amino_acid	40,50	myoglobin	63,72	Amino acid	myoglobin	CHEBI:33704	4151	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of myoglobin of the shark Galeorhinus australis .
8427632	0	Amino_acid	0,10	myoglobin	23,32	Amino acid	myoglobin	CHEBI:33704	4151	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of myoglobin from the chiton Liolophura japonica and a phylogenetic tree for molluscan globins .
962722	2	Amino_acid	36,46	myoglobin	59,68	Amino acid	myoglobin	CHEBI:33704	100091341(Tax:9258)	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Amino_acid sequence of myoglobin from the platypus , Ornithoryhynchus anatinus .
129468	0	Amino_acid	0,10	myosin	53,59	Amino acid	myosin	CHEBI:33704	79784	Chemical	Gene	composition|amod|START_ENTITY composition|nmod|END_ENTITY	Amino_acid composition of dynein and comparison with myosin .
1490997	0	Amino_acid	0,10	myosin	94,100	Amino acid	myosin	CHEBI:33704	395534(Tax:9031)	Chemical	Gene	sequence|amod|START_ENTITY smooth|nsubj|sequence smooth|dobj|END_ENTITY	Amino_acid sequence of the 20-kDa regulatory light chain of porcine aorta media smooth muscle myosin .
1939600	0	Amino_acid	0,10	myosin	124,130	Amino acid	myosin	CHEBI:33704	79784	Chemical	Gene	sequences|amod|START_ENTITY sequences|dep|comparison comparison|nmod|chains chains|compound|END_ENTITY	Amino_acid sequences of myosin essential and regulatory light chains from two clam species : comparison with other molluscan myosin light chains .
1939600	0	Amino_acid	0,10	myosin	24,30	Amino acid	myosin	CHEBI:33704	79784	Chemical	Gene	sequences|amod|START_ENTITY sequences|nmod|essential essential|amod|END_ENTITY	Amino_acid sequences of myosin essential and regulatory light chains from two clam species : comparison with other molluscan myosin light chains .
3620600	0	Amino_acid	0,10	myosin	84,90	Amino acid	myosin	CHEBI:33704	79784	Chemical	Gene	sequence|amod|START_ENTITY match|nsubj|sequence match|dobj|those those|nmod|END_ENTITY	Amino_acid sequence and structural repeats in schistosome paramyosin match those of myosin .
3801438	0	Amino_acid	0,10	myosin	23,29	Amino acid	myosin	CHEBI:33704	79784	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|chain chain|amod|END_ENTITY	Amino_acid sequence of myosin essential light chain from the scallop Aquipecten irradians .
12771422	0	Amino_acid	0,10	nsP3	46,50	Amino acid	nsP3	CHEBI:33704	10044	Chemical	Gene	mutations|amod|START_ENTITY mutations|nmod|END_ENTITY	Amino_acid mutations in the replicase protein nsP3 of Semliki_Forest_virus cumulatively affect neurovirulence .
6268146	0	Amino_acid	0,10	p15	23,26	Amino acid	p15	CHEBI:33704	1030	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of p15 from avian myeloblastosis virus complex .
8887944	0	Amino_acid	0,10	peptidyl-prolyl_isomerase_a	23,50	Amino acid	peptidyl-prolyl isomerase a	CHEBI:33704	5478	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of peptidyl-prolyl_isomerase_a of Fusarium sporotrichioides .
2775285	0	Amino_acid	0,10	pheromone-biosynthesis-activating_neuropeptide	23,69	Amino acid	pheromone-biosynthesis-activating neuropeptide	CHEBI:33704	692749(Tax:7091)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of pheromone-biosynthesis-activating_neuropeptide -LRB- PBAN -RRB- of the silkworm , Bombyx_mori .
2203790	0	Amino_acid	0,10	phosducin	39,48	Amino acid	phosducin	CHEBI:33704	287007(Tax:9913)	Chemical	Gene	sequence|compound|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid and cDNA sequence of bovine phosducin , a soluble phosphoprotein from photoreceptor cells .
1551386	0	Amino_acid	0,10	phospholipase_A2	43,59	Amino acid	phospholipase A2	CHEBI:33704	151056	Chemical	Gene	sequences|compound|START_ENTITY sequences|nmod|END_ENTITY	Amino_acid and cDNA sequences of a neutral phospholipase_A2 from the long-nosed viper -LRB- Vipera ammodytes ammodytes -RRB- venom .
6091745	0	Amino_acid	0,10	phosvitin	23,32	Amino acid	phosvitin	CHEBI:33704	100873151	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of phosvitin derived from the nucleotide sequence of part of the chicken vitellogenin gene .
3569148	0	Amino_acid	0,10	placental_protein_14	43,63	Amino acid	placental protein 14	CHEBI:33704	5047	Chemical	Gene	homology|amod|START_ENTITY homology|nmod|END_ENTITY	Amino_acid sequence homology between human placental_protein_14 and beta-lactoglobulins from various species .
7508748	0	Amino_acid	0,10	pregnancy-associated_plasma_protein-A	29,66	Amino acid	pregnancy-associated plasma protein-A	CHEBI:33704	5069	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of human pregnancy-associated_plasma_protein-A derived from cloned cDNA .
16780982	0	Amino_acid	0,10	prion_protein	38,51	Amino acid	prion protein	CHEBI:33704	5621	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of the Amur tiger prion_protein .
16925672	0	Amino_acid	0,10	prion_protein	41,54	Amino acid	prion protein	CHEBI:33704	485783(Tax:9615)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|gene gene|compound|END_ENTITY	Amino_acid sequence of the Pekingese dog prion_protein gene .
6838485	0	Amino_acid	0,10	pseudocholinesterase	48,68	Amino acid	pseudocholinesterase	CHEBI:33704	590	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of the active site of human pseudocholinesterase .
9677335	0	Amino_acid	0,10	rGSTM5	49,55	Amino acid	rGSTM5	CHEBI:33704	64352(Tax:10116)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of glutathione_S-transferase rGSTM5 * from rat testis .
3219361	0	Amino_acid	0,10	ribonuclease_inhibitor	27,49	Amino acid	ribonuclease inhibitor	CHEBI:33704	445517(Tax:9823)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of the ribonuclease_inhibitor from porcine liver reveals the presence of leucine-rich repeats .
6490607	0	Amino_acid	0,10	sarcoplasmic_calcium_binding_protein	41,77	Amino acid	sarcoplasmic calcium binding protein	CHEBI:33704	114131	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|chain chain|nmod|END_ENTITY	Amino_acid sequence of the beta chain of sarcoplasmic_calcium_binding_protein -LRB- SCP -RRB- obtained from shrimp tail muscle .
16453469	0	Amino_acid	0,10	seminalplasmin	23,37	Amino acid	seminalplasmin	CHEBI:33704	23615	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of seminalplasmin , an antimicrobial protein from bull semen .
3542030	0	Amino_acid	0,10	sex_steroid_binding_protein	27,54	Amino acid	sex steroid binding protein	CHEBI:33704	6462	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of the sex_steroid_binding_protein of human blood plasma .
1708771	0	Amino_acid	0,10	stem_cell_factor	59,75	Amino acid	stem cell factor	CHEBI:33704	60427(Tax:10116)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence and post-translational modification of stem_cell_factor isolated from buffalo_rat liver cell-conditioned medium .
510290	0	Amino_acid	0,10	sulfite_oxidase	70,85	Amino acid	sulfite oxidase	CHEBI:33704	396278(Tax:9031)	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|nsubj|sequence	Amino_acid sequence of the ` b5-like ' heme-binding domain from chicken sulfite_oxidase .
11696368	0	Amino_acid	0,10	synaptotagmin_II	124,140	Amino acid	synaptotagmin II	CHEBI:33704	127833	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Amino_acid residues before the hydrophobic region which are critical for membrane translocation of the N-terminal domain of synaptotagmin_II .
3164311	0	Amino_acid	0,10	thioredoxin	23,34	Amino acid	thioredoxin	CHEBI:33704	100359245(Tax:9986)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of thioredoxin isolated from rabbit bone marrow determined by tandem mass spectrometry .
12076650	0	Amino_acid	0,10	thrombin	25,33	Amino acid	thrombin	CHEBI:33704	280685(Tax:9913)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of a thrombin like enzyme , elegaxobin , from the venom of Trimeresurus elegans -LRB- Sakishima-habu -RRB- .
15500847	0	Amino_acid	0,10	thrombin	25,33	Amino acid	thrombin	CHEBI:33704	2147	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of a thrombin like enzyme , elegaxobin II , from the venom of Trimeresurus elegans -LRB- Sakishima-Habu -RRB- .
11786552	0	Amino_acid	0,10	thrombin-activable_fibrinolysis_inhibitor	44,85	Amino acid	thrombin-activable fibrinolysis inhibitor	CHEBI:33704	1361	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Amino_acid residues in the P6-P ' 3 region of thrombin-activable_fibrinolysis_inhibitor -LRB- TAFI -RRB- do not determine the thrombomodulin dependence of TAFI activation .
3247999	0	Amino_acid	0,10	thymopoietin	23,35	Amino acid	thymopoietin	CHEBI:33704	510267(Tax:9913)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of thymopoietin isolated from skin .
8089087	0	Amino_acid	0,10	tissue_factor_pathway_inhibitor	61,92	Amino acid	tissue factor pathway inhibitor	CHEBI:33704	613026(Tax:9544)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence and inhibitory activity of rhesus_monkey tissue_factor_pathway_inhibitor -LRB- TFPI -RRB- : comparison with human TFPI .
8639592	0	Amino_acid	0,10	tissue_factor_pathway_inhibitor	70,101	Amino acid	tissue factor pathway inhibitor	CHEBI:33704	7035	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence and carbohydrate structure of a recombinant human tissue_factor_pathway_inhibitor expressed in Chinese_hamster ovary cells : one N-and two O-linked carbohydrate chains are located between Kunitz domains 2 and 3 and one N-linked carbohydrate chain is in Kunitz domain 2 .
2900023	0	Amino_acid	0,10	transglutaminase	40,56	Amino acid	transglutaminase	CHEBI:33704	100379228(Tax:10141)	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|nsubj|sequence	Amino_acid sequence of guinea_pig liver transglutaminase from its cDNA sequence .
11435133	0	Amino_acid	0,10	troponin_C	29,39	Amino acid	troponin C	CHEBI:33704	100301551(Tax:9986)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of squid troponin_C .
1980416	0	Amino_acid	0,10	trypsin_inhibitor	46,63	Amino acid	trypsin inhibitor	CHEBI:33704	548021(Tax:3847)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Amino_acid sequence of the acidic Kunitz-type trypsin_inhibitor from winged-bean seed -LSB- Psophocarpus tetragonolobus -LRB- L. -RRB- DC -RSB- .
2631684	0	Amino_acid	1,11	tryptophanyl-tRNA-synthetase	44,72	Amino acid	tryptophanyl-tRNA synthetase	CHEBI:33704	281576(Tax:9913)	Chemical	Gene	sequence|compound|START_ENTITY sequence|nmod|END_ENTITY	-LSB- Amino_acid sequence of various peptides of tryptophanyl-tRNA-synthetase from bovine pancreas -RSB- .
17374702	0	Amino_acids	0,11	Agrp	20,24	Amino acids	Agrp	CHEBI:33709	181	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|expression expression|amod|END_ENTITY	Amino_acids inhibit Agrp gene expression via an mTOR-dependent mechanism .
21663046	0	Amino_acids	0,11	CO2	59,62	Amino acids	CO2	CHEBI:33709	717	Chemical	Gene	START_ENTITY|nmod|sequestration sequestration|compound|END_ENTITY	Amino_acids as natural inhibitors for hydrate formation in CO2 sequestration .
10913029	0	Amino_acids	0,11	PHAS-I	37,43	Amino acids	PHAS-I	CHEBI:33709	116636(Tax:10116)	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	Amino_acids regulate skeletal muscle PHAS-I and p70 S6-kinase phosphorylation independently of insulin .
8980109	0	Amino_acids	0,11	alpha1B-adrenergic_receptor	19,46	Amino acids	alpha1B-adrenergic receptor	CHEBI:33709	147	Chemical	Gene	START_ENTITY|nmod|binding binding|amod|END_ENTITY	Amino_acids of the alpha1B-adrenergic_receptor involved in agonist binding : differences in docking catecholamines to receptor subtypes .
7267234	0	Amino_acids	0,11	growth_hormone	43,57	Amino acids	growth hormone	CHEBI:33709	2688	Chemical	Gene	START_ENTITY|nmod|children children|nmod|deficiency deficiency|amod|END_ENTITY	Amino_acids as substrates in children with growth_hormone deficiency and hypoglycemia .
2051553	0	Amino_acids	0,11	insulin	20,27	Amino acids	insulin	CHEBI:33709	3630	Chemical	Gene	enhance|nsubj|START_ENTITY enhance|dobj|resistance resistance|compound|END_ENTITY	Amino_acids enhance insulin resistance to exogenous glucose infusion in overnight-fasted humans .
2692456	0	Amino_acids	0,11	insulin	20,27	Amino acids	insulin	CHEBI:33709	3630	Chemical	Gene	augment|nsubj|START_ENTITY augment|dobj|suppression suppression|nmod:poss|END_ENTITY	Amino_acids augment insulin 's suppression of whole body proteolysis .
7046464	0	Amino_acids	0,11	insulin	82,89	Amino acids	insulin	CHEBI:33709	3630	Chemical	Gene	enhance|nsubj|START_ENTITY enhance|dobj|absorption absorption|nmod|END_ENTITY	Amino_acids enhance renal tubular absorption of the los-molecular-weight proteins insulin and growth_hormone .
9142879	0	Amino_acids	0,11	insulin	48,55	Amino acids	insulin	CHEBI:33709	3630	Chemical	Gene	suppress|compound|START_ENTITY proteolysis|nsubj|suppress proteolysis|dobj|independent independent|nmod|END_ENTITY	Amino_acids suppress proteolysis independent of insulin throughout the neonatal period .
12952067	0	Amino_acids	0,11	myosin	37,43	Amino acids	myosin	CHEBI:33709	79784	Chemical	Gene	START_ENTITY|nmod|II II|compound|END_ENTITY	Amino_acids 519-524 of Dictyostelium myosin II form a surface loop that aids actin binding by facilitating a conformational change .
22157018	0	Amino_acids	0,11	ornithine_decarboxylase	58,81	Amino acids	ornithine decarboxylase	CHEBI:33709	4953	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|nmod|activity activity|amod|antizyme-1 antizyme-1|nmod|END_ENTITY	Amino_acids regulate expression of antizyme-1 to modulate ornithine_decarboxylase activity .
22907297	0	Amino_acids_395-416	1,20	STAT4	46,51	Amino acids 395-416	STAT4	null	6775	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	-LSB- Amino_acids_395-416 in DNA binding domain of STAT4 is involved in IL-12-induced nuclear import of STAT4 -RSB- .
7487060	0	Aminoacylpyrrolidine-2-nitriles	0,31	dipeptidyl-peptidase_IV	65,88	Aminoacylpyrrolidine-2-nitriles	dipeptidyl-peptidase IV	null	25253(Tax:10116)	Chemical	Gene	START_ENTITY|dep|inhibitors inhibitors|nmod|END_ENTITY	Aminoacylpyrrolidine-2-nitriles : potent and stable inhibitors of dipeptidyl-peptidase_IV -LRB- CD_26 -RRB- .
15936190	0	Aminoalkoxybenzyl_pyrrolidines	0,30	urotensin-II_receptor	46,67	Aminoalkoxybenzyl pyrrolidines	urotensin-II receptor	null	2837	Chemical	Gene	START_ENTITY|nmod|antagonists antagonists|amod|END_ENTITY	Aminoalkoxybenzyl_pyrrolidines as novel human urotensin-II_receptor antagonists .
16434195	0	Aminobenzisoxazoles	0,19	factor_Xa	90,99	Aminobenzisoxazoles	factor Xa	null	2159	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Aminobenzisoxazoles with biaryl_P4 moieties as potent , selective , and orally bioavailable factor_Xa inhibitors .
21837497	0	Aminobenzoic_acid_hydrazide	0,27	myeloperoxidase	31,46	Aminobenzoic acid hydrazide	myeloperoxidase	null	4353	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Aminobenzoic_acid_hydrazide , a myeloperoxidase inhibitor , alters the adhesive properties of neutrophils isolated from acute myocardial_infarction patients .
15745802	0	Aminocyanopyridine	0,18	mitogen_activated_protein_kinase-activated_protein_kinase_2	33,92	Aminocyanopyridine	mitogen activated protein kinase-activated protein kinase 2	null	9261	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Aminocyanopyridine inhibitors of mitogen_activated_protein_kinase-activated_protein_kinase_2 -LRB- MK-2 -RRB- .
10938531	0	Aminoethyl_Substituted_Benzyl_Ethers	47,83	Monoamine_Oxidase_B	24,43	Aminoethyl Substituted Benzyl Ethers	Monoamine Oxidase B	null	4129	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Selective Inhibition of Monoamine_Oxidase_B by Aminoethyl_Substituted_Benzyl_Ethers .
20736373	0	Aminoflavone	0,12	HIF-1alpha	66,76	Aminoflavone	HIF-1alpha	MESH:C413760	3091	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Aminoflavone , a ligand of the aryl_hydrocarbon_receptor , inhibits HIF-1alpha expression in an AhR-independent fashion .
20736373	0	Aminoflavone	0,12	aryl_hydrocarbon_receptor	30,55	Aminoflavone	aryl hydrocarbon receptor	MESH:C413760	196	Chemical	Gene	START_ENTITY|appos|ligand ligand|nmod|END_ENTITY	Aminoflavone , a ligand of the aryl_hydrocarbon_receptor , inhibits HIF-1alpha expression in an AhR-independent fashion .
2374160	0	Aminoglycoside	0,14	Ca2	27,30	Aminoglycoside	Ca2	CHEBI:47779	54231(Tax:10116)	Chemical	Gene	blockade|amod|START_ENTITY blockade|nmod|END_ENTITY	Aminoglycoside blockade of Ca2 -LRB- + -RRB- - activated K + channel from rat brain synaptosomal membranes incorporated into planar bilayers .
24683305	0	Aminoglycoside	49,63	Methyltransferase	85,102	Aminoglycoside	Methyltransferase	CHEBI:47779	1469045(Tax:186497)	Chemical	Gene	Protein|compound|START_ENTITY Protein|compound|END_ENTITY	An In Silico Approach for Characterization of an Aminoglycoside Antibiotic-Resistant Methyltransferase Protein from Pyrococcus_furiosus _ -LRB- DSM_3638 -RRB- .
16464234	0	Aminoguanidine	0,14	caspase-3	24,33	Aminoguanidine	caspase-3	MESH:C004479	25402(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	Aminoguanidine inhibits caspase-3 and calpain activation without affecting microglial activation following neonatal transient_cerebral_ischemia .
8216363	0	Aminoguanidine	0,14	catalase	69,77	Aminoguanidine	catalase	MESH:C004479	847	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Aminoguanidine : a drug proposed for prophylaxis in diabetes inhibits catalase and generates hydrogen_peroxide in vitro .
8812641	0	Aminoguanidine	11,25	iNOS	39,43	Aminoguanidine	iNOS	MESH:C004479	24599(Tax:10116)	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|compound|END_ENTITY	The Use of Aminoguanidine , a Selective iNOS Inhibitor , to Evaluate the Role of Nitric_Oxide in the Development of Autoimmune_Diabetes Insulin-dependent_diabetes_mellitus is an autoimmune_disease characterized by the selective destruction of insulin-secreting beta cells found in islets of Langerhans .
9717976	0	Aminoguanidine	0,14	iNOS	67,71	Aminoguanidine	iNOS	MESH:C004479	18126(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	Aminoguanidine reduces glomerular inducible_nitric_oxide_synthase -LRB- iNOS -RRB- and transforming_growth_factor-beta_1 -LRB- TGF-beta1 -RRB- mRNA expression and diminishes glomerulosclerosis in NZB/W F1 mice .
9717976	0	Aminoguanidine	0,14	inducible_nitric_oxide_synthase	34,65	Aminoguanidine	inducible nitric oxide synthase	MESH:C004479	18126(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|iNOS iNOS|amod|END_ENTITY	Aminoguanidine reduces glomerular inducible_nitric_oxide_synthase -LRB- iNOS -RRB- and transforming_growth_factor-beta_1 -LRB- TGF-beta1 -RRB- mRNA expression and diminishes glomerulosclerosis in NZB/W F1 mice .
22325942	0	Aminoimidazoles	0,15	BACE-1	19,25	Aminoimidazoles	BACE-1	CHEBI:22512	23821(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Aminoimidazoles as BACE-1 inhibitors : the challenge to achieve in vivo brain efficacy .
24900229	0	Aminoindazole	0,13	PDK1	14,18	Aminoindazole	PDK1	null	5163	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|compound|END_ENTITY	Aminoindazole PDK1 Inhibitors : A Case Study in Fragment-Based Drug Discovery .
17107796	0	Aminomethyl	0,11	MCH-R1	49,55	Aminomethyl	MCH-R1	null	2847	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|compound|END_ENTITY	Aminomethyl tetrahydronaphthalene ketopiperazine MCH-R1 antagonists -- Increasing selectivity over hERG .
24900243	0	Aminomethyl-pyridines	52,73	DPP-4	77,82	Aminomethyl-pyridines	DPP-4	null	1803	Chemical	Gene	START_ENTITY|nmod|Inhibitors Inhibitors|compound|END_ENTITY	Design , Synthesis , and in Vitro Evaluation of Novel Aminomethyl-pyridines as DPP-4 Inhibitors .
17107791	0	Aminomethyl_tetrahydronaphthalene_biphenyl_carboxamide	0,54	MCH-R1	55,61	Aminomethyl tetrahydronaphthalene biphenyl carboxamide	MCH-R1	MESH:C518530	2847	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|compound|END_ENTITY	Aminomethyl_tetrahydronaphthalene_biphenyl_carboxamide MCH-R1 antagonists -- Increasing selectivity over hERG .
11555834	0	Aminophylline	0,13	insulin	25,32	Aminophylline	insulin	MESH:D000628	3630	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|compound|END_ENTITY	Aminophylline stimulates insulin secretion in patients with type_2_diabetes_mellitus .
24900757	0	Aminopyrazole-Phenylalanine	0,27	GPR142	34,40	Aminopyrazole-Phenylalanine	GPR142	null	217302(Tax:10090)	Chemical	Gene	Agonists|compound|START_ENTITY Agonists|compound|END_ENTITY	Aminopyrazole-Phenylalanine Based GPR142 Agonists : Discovery of Tool Compound and in Vivo Efficacy Studies .
22326396	0	Aminopyrimidinone	0,17	cdc7	18,22	Aminopyrimidinone	cdc7	null	8317	Chemical	Gene	START_ENTITY|dobj|inhibitors inhibitors|amod|END_ENTITY	Aminopyrimidinone cdc7 kinase inhibitors .
17583500	0	Aminopyrrolidineamide	0,21	site-1_protease	36,51	Aminopyrrolidineamide	site-1 protease	null	8720	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Aminopyrrolidineamide inhibitors of site-1_protease .
25734520	0	Aminopyrrolidinone	44,62	Histone_Deacetylase_6	63,84	Aminopyrrolidinone	Histone Deacetylase 6	null	10013	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|compound|END_ENTITY	Design and Synthesis of Orally Bioavailable Aminopyrrolidinone Histone_Deacetylase_6 Inhibitors .
10593965	0	Aminosalicylic_acid	0,19	IkappaB_kinase_alpha	29,49	Aminosalicylic acid	IkappaB kinase alpha	MESH:D010131	12675(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Aminosalicylic_acid inhibits IkappaB_kinase_alpha phosphorylation of IkappaBalpha in mouse intestinal epithelial cells .
10593965	0	Aminosalicylic_acid	0,19	IkappaBalpha	69,81	Aminosalicylic acid	IkappaBalpha	MESH:D010131	18035(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Aminosalicylic_acid inhibits IkappaB_kinase_alpha phosphorylation of IkappaBalpha in mouse intestinal epithelial cells .
26985286	0	Aminotriazole	0,13	LSD1	47,51	Aminotriazole	LSD1	MESH:D000640	23028	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|nmod|END_ENTITY	Aminotriazole and Aminotetrazole Inhibitors of LSD1 as Epigenetic Modulators .
17214612	0	Amiodarone	0,10	angiotensinogen	19,34	Amiodarone	angiotensinogen	MESH:D000638	183	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Amiodarone induces angiotensinogen gene expression in lung alveolar epithelial cells through activation protein-1 .
2544810	0	Amiodarone	0,10	calmodulin	23,33	Amiodarone	calmodulin	MESH:D000638	808	Chemical	Gene	antagonist|nsubj|START_ENTITY antagonist|compound|END_ENTITY	Amiodarone is a potent calmodulin antagonist .
11288978	0	Amiodarone	0,10	interleukin-6	22,35	Amiodarone	interleukin-6	MESH:D000638	3569	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|amod|END_ENTITY	Amiodarone stimulates interleukin-6 production in cultured human thyrocytes , exerting cytotoxic effects on thyroid follicles in suspension culture .
11991672	0	Amiodarone	0,10	interleukin_6	20,33	Amiodarone	interleukin 6	MESH:D000638	16193(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Amiodarone inhibits interleukin_6 production and attenuates myocardial_injury induced by viral_myocarditis in mice .
9751232	0	Amiodarone	0,10	low-density_lipoprotein_receptor	40,72	Amiodarone	low-density lipoprotein receptor	MESH:D000638	3949	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|nmod|END_ENTITY	Amiodarone decreases gene expression of low-density_lipoprotein_receptor at both the mRNA and the protein level .
21984482	0	Amiodarone	0,10	tumor_necrosis_factor-alpha	103,130	Amiodarone	tumor necrosis factor-alpha	MESH:D000638	24835(Tax:10116)	Chemical	Gene	exposure|amod|START_ENTITY induces|nsubj|exposure induces|parataxis|role role|nmod|END_ENTITY	Amiodarone exposure during modest inflammation induces idiosyncrasy-like_liver_injury in rats : role of tumor_necrosis_factor-alpha .
9315521	0	Amiodarone	0,10	tumor_necrosis_factor-alpha	34,61	Amiodarone	tumor necrosis factor-alpha	MESH:D000638	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|nmod|END_ENTITY	Amiodarone inhibits production of tumor_necrosis_factor-alpha by human mononuclear cells : a possible mechanism for its effect in heart_failure .
19772901	0	Amitriptyline	0,13	EAAT1	26,31	Amitriptyline	EAAT1	MESH:D000639	29483(Tax:10116)	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	Amitriptyline upregulates EAAT1 and EAAT2 in neuropathic_pain rats .
19405995	0	Amitriptyline	0,13	EAAT3	69,74	Amitriptyline	EAAT3	MESH:D000639	25550(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	Amitriptyline inhibits the activity of the rat glutamate transporter EAAT3 expressed in Xenopus oocytes .
26764533	0	Amitriptyline	0,13	brain-derived_neurotrophic_factor	22,55	Amitriptyline	brain-derived neurotrophic factor	MESH:D000639	24225(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Amitriptyline induces brain-derived_neurotrophic_factor -LRB- BDNF -RRB- mRNA expression through ERK-dependent modulation of multiple BDNF mRNA variants in primary cultured rat cortical astrocytes and microglia .
9347335	0	Amitriptyline	0,13	butyrylcholinesterase	37,58	Amitriptyline	butyrylcholinesterase	MESH:D000639	590	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	Amitriptyline : a potent inhibitor of butyrylcholinesterase from human serum .
16697108	0	Amitriptyline	0,13	glutamate_transporters	60,82	Amitriptyline	glutamate transporters	MESH:D000639	29483(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	Amitriptyline suppresses neuroinflammation and up-regulates glutamate_transporters in morphine-tolerant rats .
19393774	0	Amlodipine	0,10	TNF-alpha	20,29	Amlodipine	TNF-alpha	MESH:D017311	24835(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Amlodipine inhibits TNF-alpha production and attenuates cardiac_dysfunction induced by lipopolysaccharide involving PI3K/Akt pathway .
15126926	0	Amlodipine	0,10	preproendothelin-1	34,52	Amlodipine	preproendothelin-1	MESH:D017311	24323(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Amlodipine at high dose increases preproendothelin-1 expression in the ventricles and aorta of normotensive rats .
15345494	0	Ammonia	0,7	ANG_II	92,98	Ammonia	ANG II	MESH:D000641	11606(Tax:10090)	Chemical	Gene	production|compound|START_ENTITY production|dep|role role|nmod|END_ENTITY	Ammonia production and secretion by S3 proximal tubule segments from acidotic mice : role of ANG_II .
25551173	0	Ammonia	71,78	Formylglycinamide_Ribonucleotide_Amidotransferase	21,70	Ammonia	Formylglycinamide Ribonucleotide Amidotransferase	MESH:D000641	5198	Chemical	Gene	Pathway|compound|START_ENTITY Pathway|compound|END_ENTITY	Determination of the Formylglycinamide_Ribonucleotide_Amidotransferase Ammonia Pathway by Combining 3D-RISM Theory with Experiment .
23132651	0	Ammonia	0,7	kynurenine_aminotransferase_II	20,50	Ammonia	kynurenine aminotransferase II	MESH:D000641	29416(Tax:10116)	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Ammonia upregulates kynurenine_aminotransferase_II mRNA expression in rat brain : a role for astrocytic NMDA receptors ?
16580862	0	Ammonium	0,8	RhCG	57,61	Ammonium	RhCG	MESH:D000644	51458	Chemical	Gene	properties|compound|START_ENTITY properties|nmod|cells cells|acl|expressing expressing|dobj|mutants mutants|compound|END_ENTITY	Ammonium transport properties of HEK293 cells expressing RhCG mutants : preliminary analysis of structure/function by site-directed mutagenesis .
21499893	2	Ammonium_perfluorooctanoate	196,223	PPARa	274,279	Ammonium perfluorooctanoate	PPARa	MESH:C023036	5465	Chemical	Gene	activated|nsubj|START_ENTITY activated|dobj|END_ENTITY	Ammonium_perfluorooctanoate -LRB- APFO -RRB- at 0.1 and 0.3 mg/kg doses activated mouse PPARa , but not human PPARa .
21267405	0	Amorphigenin	0,12	c-Fos	64,69	Amorphigenin	c-Fos	MESH:C049148	2353	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Amorphigenin inhibits Osteoclast differentiation by suppressing c-Fos and nuclear factor of activated T cells .
6229562	0	Amoxapine	0,9	prolactin	25,34	Amoxapine	prolactin	MESH:D000657	5617	Chemical	Gene	elevates|nsubj|START_ENTITY elevates|dobj|END_ENTITY	Amoxapine elevates serum prolactin in depressed men .
26106364	0	Amphetamine	65,76	Dopamine_Transporter	32,52	Amphetamine	Dopamine Transporter	MESH:D000661	6531	Chemical	Gene	Insights|nmod|START_ENTITY Insights|nmod|Modulation Modulation|nmod|Function Function|compound|END_ENTITY	Insights into the Modulation of Dopamine_Transporter Function by Amphetamine , Orphenadrine , and Cocaine Binding .
9365026	0	Amphetamine	0,11	Fos	55,58	Amphetamine	Fos	MESH:D000661	314322(Tax:10116)	Chemical	Gene	sensitization|amod|START_ENTITY augments|nsubj|sensitization augments|dobj|expression expression|compound|END_ENTITY	Amphetamine sensitization augments amphetamine-induced Fos expression in the lateral habenula .
12726824	0	Amphetamine	0,11	FosB	33,37	Amphetamine	FosB	MESH:D000661	100360880	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Amphetamine withdrawal modulates FosB expression in mesolimbic dopaminergic target nuclei : effects of different schedules of administration .
15194466	0	Amphetamine	0,11	JNK	97,100	Amphetamine	JNK	MESH:D000661	116554(Tax:10116)	Chemical	Gene	activates|nsubj|START_ENTITY activates|nmod|END_ENTITY	Amphetamine activates connexin43 gene expression in cultured neonatal rat cardiomyocytes through JNK and AP-1 pathway .
20649838	0	Amphetamine	0,11	NR2B	22,26	Amphetamine	NR2B	MESH:D000661	14812(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nummod|END_ENTITY	Amphetamine regulates NR2B expression in Go2a knockout mice and thereby sustains behavioral sensitization .
12099908	0	Amphetamine	0,11	Narp	40,44	Amphetamine	Narp	MESH:D000661	288475(Tax:10116)	Chemical	Gene	increase|nsubj|START_ENTITY increase|dobj|expression expression|amod|END_ENTITY	Amphetamine and cocaine do not increase Narp expression in rat ventral tegmental area , nucleus accumbens or prefrontal cortex , but Narp may contribute to individual differences in responding to a novel environment .
24824549	0	Amphetamine	37,48	Serotonin_Transporter	63,84	Amphetamine	Serotonin Transporter	MESH:D000661	6532	Chemical	Gene	Action|compound|START_ENTITY Action|nmod|END_ENTITY	Comments on `` A Quantitative Model of Amphetamine Action on the Serotonin_Transporter , by Sandtner et al. -LRB- 2013 -RRB- .
18834549	0	Amphetamine	0,11	c-Fos	60,65	Amphetamine	c-Fos	MESH:D000661	314322(Tax:10116)	Chemical	Gene	cross-tolerance|amod|START_ENTITY measured|nsubj|cross-tolerance measured|nmod|expression expression|amod|END_ENTITY	Amphetamine and pseudoephedrine cross-tolerance measured by c-Fos protein expression in brains of chronically treated rats .
11403691	0	Amphetamine	0,11	c-fos	53,58	Amphetamine	c-fos	MESH:D000661	2353	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|patterns patterns|nmod|expression expression|amod|END_ENTITY	Amphetamine and cocaine induce different patterns of c-fos mRNA expression in the striatum and subthalamic nucleus depending on environmental context .
2118661	0	Amphetamine	0,11	c-fos	63,68	Amphetamine	c-fos	MESH:D000661	2353	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|activation activation|nmod|gene gene|amod|END_ENTITY	Amphetamine and cocaine induce drug-specific activation of the c-fos gene in striosome-matrix compartments and limbic subdivisions of the striatum .
8974658	0	Amphetamine	0,11	c-fos	25,30	Amphetamine	c-fos	MESH:D000661	314322(Tax:10116)	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Amphetamine induction of c-fos in the nucleus accumbens is not inhibited by glutamate antagonists .
9027869	0	Amphetamine	0,11	c-fos	44,49	Amphetamine	c-fos	MESH:D000661	314322(Tax:10116)	Chemical	Gene	sensitization|amod|START_ENTITY enhances|nsubj|sensitization enhances|dobj|expression expression|amod|END_ENTITY	Amphetamine sensitization enhances regional c-fos expression produced by conditioned fear .
15194466	0	Amphetamine	0,11	connexin43	22,32	Amphetamine	connexin43	MESH:D000661	24392(Tax:10116)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|amod|END_ENTITY	Amphetamine activates connexin43 gene expression in cultured neonatal rat cardiomyocytes through JNK and AP-1 pathway .
22804716	0	Amphetamine	0,11	dopamine_transporter	48,68	Amphetamine	dopamine transporter	MESH:D000661	6531	Chemical	Gene	reduce|nsubj|START_ENTITY reduce|dobj|function function|compound|END_ENTITY	Amphetamine and methamphetamine reduce striatal dopamine_transporter function without concurrent dopamine_transporter relocalization .
22804716	0	Amphetamine	0,11	dopamine_transporter	97,117	Amphetamine	dopamine transporter	MESH:D000661	6531	Chemical	Gene	reduce|nsubj|START_ENTITY reduce|nmod|relocalization relocalization|compound|END_ENTITY	Amphetamine and methamphetamine reduce striatal dopamine_transporter function without concurrent dopamine_transporter relocalization .
26553986	0	Amphetamine	0,11	dopamine_transporter	54,74	Amphetamine	dopamine transporter	MESH:D000661	13162(Tax:10090)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|GTPase GTPase|acl|signaling signaling|xcomp|mediate mediate|dobj|effects effects|amod|END_ENTITY	Amphetamine activates Rho GTPase signaling to mediate dopamine_transporter internalization and acute behavioral effects of amphetamine .
17032905	0	Amphetamine	0,11	norepinephrine_transporter	92,118	Amphetamine	norepinephrine transporter	MESH:D000661	6530	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|expression expression|compound|END_ENTITY	Amphetamine induces a calcium/calmodulin-dependent _ protein_kinase_II-dependent reduction in norepinephrine_transporter surface expression linked to changes in syntaxin_1A / transporter complexes .
26019340	0	Amphetamine	0,11	serotonin_transporter	64,85	Amphetamine	serotonin transporter	MESH:D000661	15567(Tax:10090)	Chemical	Gene	action|amod|START_ENTITY action|nmod|END_ENTITY	Amphetamine action at the cocaine - and antidepressant-sensitive serotonin_transporter is modulated by aCaMKII .
25064453	0	Amphotericin_B	0,14	IL-8	90,94	Amphotericin B	IL-8	MESH:D000666	3576	Chemical	Gene	START_ENTITY|dobj|production production|nmod|END_ENTITY	Amphotericin_B down-regulates Aggregatibacter_actinomycetemcomitans-induced production of IL-8 and IL-6 in human gingival epithelial cells .
16189267	0	Amphotericin_B	0,14	erythropoietin	22,36	Amphotericin B	erythropoietin	MESH:D000666	2056	Chemical	Gene	blunts|nsubj|START_ENTITY blunts|dobj|response response|compound|END_ENTITY	Amphotericin_B blunts erythropoietin response to hypoxia by reinforcing FIH-mediated repression of HIF-1 .
2299214	0	Amphotericin_B	0,14	erythropoietin	22,36	Amphotericin B	erythropoietin	MESH:D000666	2056	Chemical	Gene	blunts|nsubj|START_ENTITY blunts|dobj|response response|compound|END_ENTITY	Amphotericin_B blunts erythropoietin response to anemia .
25283947	0	Amphotericin_B	0,14	glial_cell_line-derived_neurotrophic_factor	23,66	Amphotericin B	glial cell line-derived neurotrophic factor	MESH:D000666	25453(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Amphotericin_B induces glial_cell_line-derived_neurotrophic_factor in the rat brain .
2871108	0	Amphotericin_B	0,14	tissue_transglutaminase	56,79	Amphotericin B	tissue transglutaminase	MESH:D000666	21817(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Amphotericin_B inhibits the serum-induced expression of tissue_transglutaminase in murine peritoneal macrophages .
25503432	0	Amrubicin	17,26	LUN	104,107	Amrubicin	LUN	MESH:C055866	10210	Chemical	Gene	Study|nmod|START_ENTITY Study|dep|END_ENTITY	Phase I Study of Amrubicin and Cyclophosphamide in Patients With Advanced Solid Organ Malignancies : HOG LUN 07-130 .
24122234	0	Amsacrine	0,9	matrix_metalloproteinase-2	21,47	Amsacrine	matrix metalloproteinase-2	MESH:D000677	4313	Chemical	Gene	suppresses|amod|START_ENTITY suppresses|dep|END_ENTITY	Amsacrine suppresses matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- / MMP-9 expression in human leukemia cells .
20713551	0	Amurensin_G	0,11	SIRT1	30,35	Amurensin G	SIRT1	MESH:C553921	23411	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Amurensin_G , a potent natural SIRT1 inhibitor , rescues doxorubicin responsiveness via down-regulation of multidrug_resistance_1 .
22483777	0	Amurensin_G	0,11	SIRT1	21,26	Amurensin G	SIRT1	MESH:C553921	23411	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Amurensin_G , a novel SIRT1 inhibitor , sensitizes TRAIL-resistant human leukemic K562 cells to TRAIL-induced apoptosis .
24813716	0	Amyrone	3,10	cyclooxygenase-2	36,52	Amyrone	cyclooxygenase-2	MESH:C511312	19225(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	- Amyrone , a specific inhibitor of cyclooxygenase-2 , exhibits anti-inflammatory effects in vitro and in vivo of mice .
24627774	0	Anacardic_acid	0,14	IL-8	77,81	Anacardic acid	IL-8	MESH:C088115	3576	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|compound|END_ENTITY	Anacardic_acid , a histone acetyltransferase inhibitor , modulates LPS-induced IL-8 expression in a human alveolar epithelial cell line A549 .
23359208	0	Anacardic_acid	0,14	androgen_receptor	109,126	Anacardic acid	androgen receptor	MESH:C088115	367	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|inhibition inhibition|nmod|END_ENTITY	Anacardic_acid -LRB- 6-pentadecylsalicylic_acid -RRB- induces apoptosis of prostate_cancer cells through inhibition of androgen_receptor and activation of p53 signaling .
22745359	0	Anacardic_acid	0,14	matrix_metalloproteinase-2_and_matrix_metalloproteinase-9	50,107	Anacardic acid	matrix metalloproteinase-2 and matrix metalloproteinase-9	MESH:C088115	17390;17395	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	Anacardic_acid inhibits the catalytic activity of matrix_metalloproteinase-2_and_matrix_metalloproteinase-9 .
25008069	0	Anacetrapib	0,11	CETP	140,144	Anacetrapib	CETP	MESH:C530884	1071	Chemical	Gene	alters|amod|START_ENTITY HDL|nsubj|alters HDL|ccomp|reverse reverse|nmod|levels levels|nmod|inhibition inhibition|compound|END_ENTITY	Anacetrapib and dalcetrapib differentially alters HDL metabolism and macrophage-to-feces reverse cholesterol transport at similar levels of CETP inhibition in hamsters .
23337530	0	Anagliptin	0,10	DPP-4	14,19	Anagliptin	DPP-4	null	13482(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Anagliptin , a DPP-4 inhibitor , suppresses proliferation of vascular smooth muscles and monocyte inflammatory reaction and attenuates_atherosclerosis in male apo_E-deficient mice .
26147347	0	Anagliptin	0,10	dipeptidyl_peptidase_IV	21,44	Anagliptin	dipeptidyl peptidase IV	null	1803	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Anagliptin , a potent dipeptidyl_peptidase_IV inhibitor : its single-crystal structure and enzyme interactions .
25267366	0	Anamorelin_HCl	0,14	ghrelin_receptor	35,51	Anamorelin HCl	ghrelin receptor	null	2693	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Anamorelin_HCl -LRB- ONO-7643 -RRB- , a novel ghrelin_receptor agonist , for the treatment of cancer_anorexia-cachexia_syndrome : preclinical profile .
10051770	0	Anandamide	0,10	CB1	106,109	Anandamide	CB1	MESH:C078814	12801(Tax:10090)	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|nmod|receptors receptors|amod|distinct distinct|nmod|receptors receptors|nummod|END_ENTITY	Anandamide and WIN_55212-2 inhibit cyclic_AMP formation through G-protein-coupled receptors distinct from CB1 cannabinoid receptors in cultured astrocytes .
10353436	0	Anandamide	0,10	CB1	65,68	Anandamide	CB1	MESH:C078814	25248(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|overeating overeating|dep|mediation mediation|nmod|receptors receptors|appos|END_ENTITY	Anandamide induces overeating : mediation by central cannabinoid -LRB- CB1 -RRB- receptors .
15288572	0	Anandamide	0,10	CB1	172,175	Anandamide	CB1	MESH:C078814	25248(Tax:10116)	Chemical	Gene	AM404|amod|START_ENTITY inhibit|nsubj|AM404 inhibit|nmod|culture culture|nmod|receptors receptors|compound|END_ENTITY	Anandamide transport inhibitor AM404 and structurally related compounds inhibit synaptic transmission between rat hippocampal neurons in culture independent of cannabinoid CB1 receptors .
17850365	0	Anandamide	0,10	CB1	147,150	Anandamide	CB1	MESH:C078814	25248(Tax:10116)	Chemical	Gene	improves|nsubj|START_ENTITY improves|dobj|relaxation relaxation|dep|involvement involvement|nmod|END_ENTITY	Anandamide improves the impaired nitric_oxide-mediated neurogenic relaxation of the corpus cavernosum in diabetic rats : involvement of cannabinoid CB1 and vanilloid VR1 receptors .
18165231	0	Anandamide	0,10	CB1	83,86	Anandamide	CB1	MESH:C078814	1268	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|advcl|inducing inducing|nmod|manner manner|compound|END_ENTITY	Anandamide regulates keratinocyte differentiation by inducing DNA methylation in a CB1 receptor-dependent manner .
21575494	0	Anandamide	1,11	CB1	67,70	Anandamide	CB1	MESH:C078814	1268	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Anandamide inhibits the growth of colorectal_cancer cells through CB1 and lipid rafts -RSB- .
23220721	0	Anandamide	0,10	CB1	92,95	Anandamide	CB1	MESH:C078814	1268	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|activating activating|dobj|receptors receptors|nummod|END_ENTITY	Anandamide inhibits transport-related oxygen consumption in the loop of Henle by activating CB1 receptors .
24508153	0	Anandamide	0,10	CB1	25,28	Anandamide	CB1	MESH:C078814	25248(Tax:10116)	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|receptors receptors|nummod|END_ENTITY	Anandamide activation of CB1 receptors increases spontaneous bursting and oscillatory activity in the thalamus .
25136404	0	Anandamide	0,10	CB1	74,77	Anandamide	CB1	MESH:C078814	12801(Tax:10090)	Chemical	Gene	protects|nsubj|START_ENTITY protects|dobj|cells cells|acl|exposed exposed|xcomp|hydrogen_peroxide hydrogen_peroxide|advcl|inhibiting inhibiting|dobj|type type|nummod|END_ENTITY	Anandamide protects HT22 cells exposed to hydrogen_peroxide by inhibiting CB1 receptor-mediated type 2 NADPH oxidase .
25684344	0	Anandamide	0,10	CB1	49,52	Anandamide	CB1	MESH:C078814	25248(Tax:10116)	Chemical	Gene	drives|nsubj|START_ENTITY drives|nmod|receptors receptors|nummod|END_ENTITY	Anandamide drives cell cycle progression through CB1 receptors in a rat model of synchronized liver regeneration .
17055492	0	Anandamide	0,10	Cdk2	20,24	Anandamide	Cdk2	MESH:C078814	1017	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Anandamide inhibits Cdk2 and activates Chk1 leading to cell cycle arrest in human breast_cancer cells .
25205244	0	Anandamide	0,10	FAAH	25,29	Anandamide	FAAH	MESH:C078814	2166	Chemical	Gene	Hydrolysis|compound|START_ENTITY Hydrolysis|nmod|END_ENTITY	Anandamide Hydrolysis in FAAH Reveals a Dual Strategy for Efficient Enzyme-Assisted Amide Bond Cleavage via Nitrogen Inversion .
21802420	0	Anandamide	0,10	GnRH-II	39,46	Anandamide	GnRH-II	MESH:C078814	2797	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	Anandamide modulates the expression of GnRH-II and GnRHRs in frog , Rana esculenta , diencephalon .
22669247	0	Anandamide	0,10	GnRH1	39,44	Anandamide	GnRH1	MESH:C078814	2796	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Anandamide regulates the expression of GnRH1 , GnRH2 , and GnRH-Rs in frog testis .
19565660	0	Anandamide	0,10	IL-10	20,25	Anandamide	IL-10	MESH:C078814	3586	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|compound|END_ENTITY	Anandamide enhances IL-10 production in activated microglia by targeting CB -LRB- 2 -RRB- receptors : roles of ERK1/2 , JNK , and NF-kappaB .
14517174	0	Anandamide	0,10	TRPV1	25,30	Anandamide	TRPV1	MESH:C078814	7442	Chemical	Gene	START_ENTITY|dobj|receptors receptors|nummod|END_ENTITY	Anandamide and vanilloid TRPV1 receptors .
15277315	0	Anandamide	0,10	TRPV1	78,83	Anandamide	TRPV1	MESH:C078814	7442	Chemical	Gene	acts|nsubj|START_ENTITY acts|advcl|activating activating|dobj|receptors receptors|nummod|END_ENTITY	Anandamide acts as a vasodilator of dural blood vessels in vivo by activating TRPV1 receptors .
16081483	0	Anandamide	0,10	TRPV1	72,77	Anandamide	TRPV1	MESH:C078814	83810(Tax:10116)	Chemical	Gene	elicits|nsubj|START_ENTITY elicits|dobj|release release|nmod|bed bed|amod|nitric_oxide nitric_oxide|nmod|activation activation|compound|END_ENTITY	Anandamide elicits an acute release of nitric_oxide through endothelial TRPV1 receptor activation in the rat arterial mesenteric bed .
16107881	0	Anandamide	0,10	TRPV1	73,78	Anandamide	TRPV1	MESH:C078814	83810(Tax:10116)	Chemical	Gene	acts|nsubj|START_ENTITY acts|nmod|messenger messenger|acl|amplifying amplifying|dobj|influx influx|nmod|channels channels|nummod|END_ENTITY	Anandamide acts as an intracellular messenger amplifying Ca2 + influx via TRPV1 channels .
19647120	0	Anandamide	0,10	TRPV1	39,44	Anandamide	TRPV1	MESH:C078814	7442	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Anandamide and the vanilloid receptor -LRB- TRPV1 -RRB- .
21903882	0	Anandamide	0,10	TRPV1	63,68	Anandamide	TRPV1	MESH:C078814	83810(Tax:10116)	Chemical	Gene	modulates|amod|START_ENTITY carotid|nsubj|modulates carotid|dobj|activity activity|nmod|receptors receptors|nummod|END_ENTITY	Anandamide modulates carotid sinus nerve afferent activity via TRPV1 receptors increasing responses to heat .
21851608	0	Anandamide	0,10	VCAM-1	44,50	Anandamide	VCAM-1	MESH:C078814	22329(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Anandamide inhibits Theiler 's _ virus induced VCAM-1 in brain endothelial cells and reduces leukocyte transmigration in a model of blood brain barrier by activation of CB -LRB- 1 -RRB- receptors .
21664223	0	Anandamide	0,10	butyrylcholinesterase	50,71	Anandamide	butyrylcholinesterase	MESH:C078814	590	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|END_ENTITY	Anandamide and its congeners inhibit human plasma butyrylcholinesterase .
17114903	0	Anandamide	0,10	endothelin-1	20,32	Anandamide	endothelin-1	MESH:C078814	1906	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Anandamide inhibits endothelin-1 production by human cultured endothelial cells : a new vascular action of this endocannabinoid .
23701964	0	Anastrozole	0,11	estrogen_receptor_a	34,53	Anastrozole	estrogen receptor a	MESH:C090450	2099	Chemical	Gene	START_ENTITY|dep|Effects Effects|nmod|END_ENTITY	Anastrozole and RU486 : Effects on estrogen_receptor_a and Mucin_1 expression and correlation in the MCF-7_breast_cancer cell line .
8344190	0	Androgen	0,8	5_alpha-reductase	30,47	Androgen	5 alpha-reductase	CHEBI:50113	6715	Chemical	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	Androgen induction of steroid 5_alpha-reductase may be mediated via insulin-like_growth_factor-I .
1236074	0	Androgen	0,8	ABP	81,84	Androgen	ABP	CHEBI:50113	6462	Chemical	Gene	binding|compound|START_ENTITY binding|dep|production production|nmod|androgen_binding_protein androgen_binding_protein|appos|END_ENTITY	Androgen binding in the testis : in vitro production of androgen_binding_protein -LRB- ABP -RRB- by Sertoli cell cultures and measurement of nuclear bound androgen by a nuclear exchange assay .
20590445	0	Androgen	0,8	ADAMTS15	19,27	Androgen	ADAMTS15	CHEBI:50113	170689	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Androgen regulates ADAMTS15 gene expression in prostate_cancer cells .
22155408	0	Androgen	0,8	AR	75,77	Androgen	AR	CHEBI:50113	367	Chemical	Gene	HN1|compound|START_ENTITY leads|nsubj|HN1 leads|dobj|degradation degradation|nmod|androgen_receptor androgen_receptor|appos|END_ENTITY	Androgen regulated HN1 leads proteosomal degradation of androgen_receptor -LRB- AR -RRB- and negatively influences AR mediated transactivation in prostate cells .
26847655	0	Androgen	0,8	AR	45,47	Androgen	AR	CHEBI:50113	367	Chemical	Gene	ablation|compound|START_ENTITY elicits|nsubj|ablation elicits|dobj|PP1-dependence PP1-dependence|nmod|stabilization stabilization|compound|END_ENTITY	Androgen ablation elicits PP1-dependence for AR stabilization and transactivation in prostate_cancer .
25500996	0	Androgen	80,88	Androgen_Receptor	31,48	Androgen	Androgen Receptor	CHEBI:50113	367	Chemical	Gene	Syndrome|compound|START_ENTITY Activity|nmod|Syndrome Activity|nmod|Mutations Mutations|compound|END_ENTITY	Promoter-Dependent Activity on Androgen_Receptor N-Terminal Domain Mutations in Androgen Insensitivity Syndrome .
26522430	0	Androgen	13,21	Androgen_Receptor	24,41	Androgen	Androgen Receptor	CHEBI:50113	11835(Tax:10090)	Chemical	Gene	Roles|nmod|START_ENTITY Roles|dep|System System|compound|END_ENTITY	Roles of the Androgen - Androgen_Receptor System in Vascular Angiogenesis .
15124003	0	Androgen	0,8	Bcl-2	62,67	Androgen	Bcl-2	CHEBI:50113	596	Chemical	Gene	signaling|nmod:npmod|START_ENTITY signaling|nmod|END_ENTITY	Androgen signaling and post-transcriptional downregulation of Bcl-2 in androgen-unresponsive_prostate_cancer .
11311483	0	Androgen	0,8	CYP4B1	123,129	Androgen	CYP4B1	CHEBI:50113	24307(Tax:10116)	Chemical	Gene	regulation|compound|START_ENTITY regulation|dep|detection detection|nmod|mRNA mRNA|compound|END_ENTITY	Androgen regulation of CYP4B1 responsible for mutagenic activation of bladder_carcinogens in the rat bladder : detection of CYP4B1 mRNA by competitive reverse transcription-polymerase chain reaction .
11311483	0	Androgen	0,8	CYP4B1	23,29	Androgen	CYP4B1	CHEBI:50113	24307(Tax:10116)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Androgen regulation of CYP4B1 responsible for mutagenic activation of bladder_carcinogens in the rat bladder : detection of CYP4B1 mRNA by competitive reverse transcription-polymerase chain reaction .
18541154	0	Androgen	0,8	Cdc6	19,23	Androgen	Cdc6	CHEBI:50113	990	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|amod|END_ENTITY	Androgen regulates Cdc6 transcription through interactions between androgen_receptor and E2F transcription factor in prostate_cancer cells .
25271736	0	Androgen	0,8	Cdk2	129,133	Androgen	Cdk2	CHEBI:50113	1017	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|proliferation proliferation|nmod|cells cells|nmod|inhibition inhibition|nmod|END_ENTITY	Androgen suppresses the proliferation of androgen_receptor-positive castration-resistant_prostate_cancer cells via inhibition of Cdk2 , CyclinA , and Skp2 .
25330338	0	Androgen	12,20	Cdk2	141,145	Androgen	Cdk2	CHEBI:50113	1017	Chemical	Gene	Suppresses|compound|START_ENTITY Suppresses|dep|Proliferation Proliferation|nmod|Cells Cells|nmod|Inhibition Inhibition|nmod|END_ENTITY	Correction : Androgen Suppresses the Proliferation of Androgen_Receptor-Positive Castration-Resistant Prostate_Cancer Cells via Inhibition of Cdk2 , CyclinA , and Skp2 .
9777371	0	Androgen	0,8	FGF-1	44,49	Androgen	FGF-1	CHEBI:50113	2246	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Androgen regulation of prostate_cancer cell FGF-1 , FGF-2 , and FGF-8 : preferential down-regulation of FGF-2 transcripts .
3090004	0	Androgen	0,8	GnRH	73,77	Androgen	GnRH	CHEBI:50113	2796	Chemical	Gene	effects|compound|START_ENTITY effects|nmod|END_ENTITY	Androgen and estradiol effects on gonadotropin secretion and response to GnRH in ovariectomized pony mares .
7828344	0	Androgen	0,8	GnRH	31,35	Androgen	GnRH	CHEBI:50113	2796	Chemical	Gene	effect|compound|START_ENTITY effect|nmod|END_ENTITY	Androgen suppressive effect of GnRH agonist in ovarian_hyperthecosis_and_virilizing_tumours .
25642745	0	Androgen	81,89	Gonadotropin-Releasing_Hormone	16,46	Androgen	Gonadotropin-Releasing Hormone	CHEBI:50113	2796	Chemical	Gene	Abuse|compound|START_ENTITY Men|nmod|Abuse Response|nmod|Men Response|nmod|END_ENTITY	The Response to Gonadotropin-Releasing_Hormone and hCG in Men with Prior Chronic Androgen Steroid Abuse and Clinical Hypogonadism .
15223850	0	Androgen	0,8	JM-27	23,28	Androgen	JM-27	CHEBI:50113	9506	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Androgen regulation of JM-27 is associated with the diseased prostate .
17003774	0	Androgen	0,8	MRP4	69,73	Androgen	MRP4	CHEBI:50113	10257	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Androgen induces expression of the multidrug resistance protein gene MRP4 in prostate_cancer cells .
9510071	0	Androgen	0,8	MSVSP99	53,60	Androgen	MSVSP99	CHEBI:50113	20945(Tax:10090)	Chemical	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	Androgen induction of the SVS family related protein MSVSP99 : identification of a functional androgen response element .
26636186	0	Androgen	0,8	Mafb	19,23	Androgen	Mafb	CHEBI:50113	16658(Tax:10090)	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Androgen Regulates Mafb Expression Through its 3 ` UTR During Mouse Urethral Masculinization .
17369855	0	Androgen	0,8	PEG10	19,24	Androgen	PEG10	CHEBI:50113	23089	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Androgen activates PEG10 to promote carcinogenesis in hepatic_cancer cells .
14715247	0	Androgen	0,8	PML	20,23	Androgen	PML	CHEBI:50113	5371	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Androgen suppresses PML protein expression in prostate_cancer CWR22R cells .
9537288	0	Androgen	0,8	Pem	27,30	Androgen	Pem	CHEBI:50113	18617(Tax:10090)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|gene gene|compound|END_ENTITY	Androgen regulation of the Pem homeodomain gene in mice and rat Sertoli and epididymal cells .
25103271	0	Androgen	8,16	Prostate-Specific_Antigen	84,109	Androgen	Prostate-Specific Antigen	CHEBI:50113	354	Chemical	Gene	Therapy|compound|START_ENTITY Role|nmod|Therapy Role|nmod|Level Level|compound|END_ENTITY	Role of Androgen Deprivation Therapy in Early Salvage Radiation Among Patients With Prostate-Specific_Antigen Level of 0.5 or Less .
25234025	0	Androgen	195,203	Prostate-Specific_Antigen	35,60	Androgen	Prostate-Specific Antigen	CHEBI:50113	354	Chemical	Gene	Therapy|compound|START_ENTITY Significance|dep|Therapy Significance|nmod|Time Time|nmod|Nadir Nadir|compound|END_ENTITY	Prognostic Significance of Time to Prostate-Specific_Antigen -LRB- PSA -RRB- Nadir and Its Relationship to Survival Beyond Time to PSA Nadir for Prostate_Cancer Patients With Bone Metastases After Primary Androgen Deprivation Therapy .
25533418	0	Androgen	106,114	Prostate-specific_Antigen	40,65	Androgen	Prostate-specific Antigen	CHEBI:50113	354	Chemical	Gene	Therapy|compound|START_ENTITY Virus|nmod|Therapy Virus|nsubj|Study Study|nmod|Pox Pox|compound|END_ENTITY	A National Multicenter Phase 2 Study of Prostate-specific_Antigen -LRB- PSA -RRB- Pox Virus Vaccine with Sequential Androgen Ablation Therapy in Patients with PSA Progression : ECOG 9802 .
24109594	0	Androgen	0,8	TMPRSS2	27,34	Androgen	TMPRSS2	CHEBI:50113	7113	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|gene gene|compound|END_ENTITY	Androgen regulation of the TMPRSS2 gene and the effect of a SNP in an androgen response element .
20043080	0	Androgen	0,8	TRPM8	19,24	Androgen	TRPM8	CHEBI:50113	79054	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Androgen regulated TRPM8 expression : a potential mRNA marker for metastatic_prostate_cancer detection in body fluids .
8473234	0	Androgen	0,8	UDP-glucuronyl_transferase	9,35	Androgen	UDP-glucuronyl transferase	CHEBI:50113	574523(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Androgen UDP-glucuronyl_transferase activity is found primarily in liver in the rat .
9154505	0	Androgen	0,8	UDP-glucuronyl_transferase	9,35	Androgen	UDP-glucuronyl transferase	CHEBI:50113	54657	Chemical	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Androgen UDP-glucuronyl_transferase activity is found primarily in the liver in the human .
3011597	0	Androgen	0,8	alcohol_dehydrogenase	22,43	Androgen	alcohol dehydrogenase	CHEBI:50113	58810(Tax:10090)	Chemical	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	Androgen induction of alcohol_dehydrogenase in mouse kidney .
17526768	0	Androgen	0,8	aldehyde_dehydrogenase_1A3	23,49	Androgen	aldehyde dehydrogenase 1A3	CHEBI:50113	220	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Androgen regulation of aldehyde_dehydrogenase_1A3 -LRB- ALDH1A3 -RRB- in the androgen-responsive human prostate_cancer cell line LNCaP .
1688854	0	Androgen	0,8	alpha_2u-globulin	37,54	Androgen	alpha 2u-globulin	CHEBI:50113	298111(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|gene gene|amod|END_ENTITY	Androgen regulated expression of the alpha_2u-globulin gene in pancreatic hepatocytes of rat .
10076535	0	Androgen	0,8	androgen_receptor	98,115	Androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	effect|amod|START_ENTITY metabolites|nsubj|effect metabolites|nmod|END_ENTITY	Androgen antagonistic effect of estramustine_phosphate -LRB- EMP -RRB- metabolites on wild-type and mutated androgen_receptor .
10395065	0	Androgen	0,8	androgen_receptor	68,85	Androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	effects|nsubj|START_ENTITY effects|nmod|change change|nmod|END_ENTITY	Androgen effects on the solubility and conformational change of the androgen_receptor in baculovirus expression system .
10598582	0	Androgen	177,185	androgen_receptor	30,47	Androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	sequestration|nmod|START_ENTITY receptor|nmod|sequestration inactivation|nmod|receptor causes|dobj|inactivation causes|nsubj|mutation mutation|nmod|END_ENTITY	A C619Y mutation in the human androgen_receptor causes inactivation and mislocalization of the receptor with concomitant sequestration of SRC-1 _ -LRB- steroid_receptor_coactivator_1 -RRB- Androgen ablation therapy is a primary treatment for advanced_prostate_cancer , but tumors become refractive to therapy .
10809237	0	Androgen	0,8	androgen_receptor	74,91	Androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	induction|compound|START_ENTITY inhibitor|nsubj|induction inhibitor|parataxis|complex complex|dep|role role|nmod|Sp1 Sp1|compound|END_ENTITY	Androgen induction of cyclin-dependent kinase inhibitor p21 gene : role of androgen_receptor and transcription factor Sp1 complex .
12239101	0	Androgen	0,8	androgen_receptor	100,117	Androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	modulation|compound|START_ENTITY modulation|acl|expressing expressing|dobj|END_ENTITY	Androgen modulation of adhesion and antiadhesion molecules in PC-3_prostate_cancer cells expressing androgen_receptor .
1458719	0	Androgen	0,8	androgen_receptor	43,60	Androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	resistance|nsubj|START_ENTITY resistance|xcomp|due due|nmod|mutation mutation|nmod|END_ENTITY	Androgen resistance due to mutation of the androgen_receptor .
1752359	0	Androgen	0,8	androgen_receptor	47,64	Androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	resistance|compound|START_ENTITY caused|nsubj|resistance caused|nmod|gene gene|compound|END_ENTITY	Androgen resistance caused by mutations in the androgen_receptor gene .
17975004	0	Androgen	0,8	androgen_receptor	26,43	Androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	induction|compound|START_ENTITY induction|nmod|four_and_a_half_LIM_domain_protein-2 four_and_a_half_LIM_domain_protein-2|compound|END_ENTITY	Androgen induction of the androgen_receptor coactivator four_and_a_half_LIM_domain_protein-2 : evidence for a role for serum_response_factor in prostate_cancer .
1820979	0	Androgen	0,8	androgen_receptor	19,36	Androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|protein protein|compound|END_ENTITY	Androgen increases androgen_receptor protein while decreasing receptor mRNA in LNCaP cells .
18541154	0	Androgen	0,8	androgen_receptor	67,84	Androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|interactions interactions|nmod|factor factor|compound|END_ENTITY	Androgen regulates Cdc6 transcription through interactions between androgen_receptor and E2F transcription factor in prostate_cancer cells .
1856263	0	Androgen	0,8	androgen_receptor	54,71	Androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	resistance|compound|START_ENTITY resistance|acl|associated associated|nmod|mutation mutation|nmod|END_ENTITY	Androgen resistance associated with a mutation of the androgen_receptor at amino_acid 772 -LRB- Arg -- Cys -RRB- results from a combination of decreased messenger ribonucleic_acid levels and impairment_of_receptor_function .
18673534	0	Androgen	0,8	androgen_receptor	27,44	Androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Androgen regulation of the androgen_receptor coregulators .
19366880	0	Androgen	0,8	androgen_receptor	69,86	Androgen	androgen receptor	CHEBI:50113	11835(Tax:10090)	Chemical	Gene	sensitivity|compound|START_ENTITY enhanced|nsubjpass|sensitivity enhanced|nmod|inactivation inactivation|compound|END_ENTITY	Androgen sensitivity of prostate epithelium is enhanced by postnatal androgen_receptor inactivation .
19912960	0	Androgen	0,8	androgen_receptor	23,40	Androgen	androgen receptor	CHEBI:50113	24208(Tax:10116)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|ribonucleic_Acid ribonucleic_Acid|compound|END_ENTITY	Androgen regulation of androgen_receptor messenger ribonucleic_Acid differs in rat prostate and selected brain areas .
20133446	0	Androgen	139,147	androgen_receptor	49,66	Androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	Study|compound|START_ENTITY impact|dep|Study impact|nmod|polymorphism polymorphism|nmod|gene gene|compound|END_ENTITY	The impact of the CAG repeat polymorphism of the androgen_receptor gene on muscle and adipose tissues in 20-29-year-old Danish men : Odense Androgen Study .
20817090	0	Androgen	0,8	androgen_receptor	83,100	Androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	activation|nsubj|START_ENTITY activation|nmod|tethering tethering|nmod|END_ENTITY	Androgen activation of the folate_receptor_a gene through partial tethering of the androgen_receptor by C/EBPa .
21257919	0	Androgen	0,8	androgen_receptor	58,75	Androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|proliferation proliferation|nmod|mechanism mechanism|amod|END_ENTITY	Androgen stimulates endothelial cell proliferation via an androgen_receptor / VEGF/cyclin _ A-mediated mechanism .
21781227	0	Androgen	0,8	androgen_receptor	101,118	Androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	Androgen suppresses proliferation of castration-resistant LNCaP 104-R2 prostate_cancer cells through androgen_receptor , Skp2 , and c-Myc .
22155408	0	Androgen	0,8	androgen_receptor	56,73	Androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	HN1|compound|START_ENTITY leads|nsubj|HN1 leads|dobj|degradation degradation|nmod|END_ENTITY	Androgen regulated HN1 leads proteosomal degradation of androgen_receptor -LRB- AR -RRB- and negatively influences AR mediated transactivation in prostate cells .
22360658	0	Androgen	0,8	androgen_receptor	67,84	Androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	deprivation|compound|START_ENTITY causes|nsubj|deprivation causes|dobj|truncation truncation|nmod|region region|nmod|END_ENTITY	Androgen deprivation causes truncation of the C-terminal region of androgen_receptor in human prostate_cancer LNCaP cells .
2362427	0	Androgen	0,8	androgen_receptor	48,65	Androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	resistance|compound|START_ENTITY resistance|amod|due due|nmod|amounts amounts|nmod|END_ENTITY	Androgen resistance due to decreased amounts of androgen_receptor : a reinvestigation .
24100013	0	Androgen	0,8	androgen_receptor	78,95	Androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|import import|nmod|END_ENTITY	Androgen induces a switch from cytoplasmic retention to nuclear import of the androgen_receptor .
24151599	0	Androgen	0,8	androgen_receptor	77,94	Androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|expression expression|compound|END_ENTITY	Androgen signaling disruption during fetal and postnatal development affects androgen_receptor and connexin_43 expression and distribution in adult boar prostate .
25344864	0	Androgen	0,8	androgen_receptor	88,105	Androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	therapy|compound|START_ENTITY sensitizes|nsubj|therapy sensitizes|nmod|T-cell T-cell|acl|killing killing|nmod|modulation modulation|compound|END_ENTITY	Androgen deprivation therapy sensitizes prostate_cancer cells to T-cell killing through androgen_receptor dependent modulation of the apoptotic pathway .
26285813	0	Androgen	0,8	androgen_receptor	21,38	Androgen	androgen receptor	CHEBI:50113	11835(Tax:10090)	Chemical	Gene	actions|compound|START_ENTITY actions|nmod|END_ENTITY	Androgen actions via androgen_receptor promote PTEN inactivation induced uterine cancer .
26876983	0	Androgen	14,22	androgen_receptor	87,104	Androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	Resource|compound|START_ENTITY Regulators|nmod|Resource Regulators|dep|shop shop|nmod|study study|nmod|action action|compound|END_ENTITY	Regulators of Androgen Action Resource : a one-stop shop for the comprehensive study of androgen_receptor action .
27015557	0	Androgen	0,8	androgen_receptor	109,126	Androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	therapy|compound|START_ENTITY sensitizes|nsubj|therapy sensitizes|nmod|modulation modulation|compound|END_ENTITY	Androgen deprivation therapy sensitizes triple negative breast_cancer cells to immune-mediated lysis through androgen_receptor independent modulation of osteoprotegerin .
2918059	0	Androgen	0,8	androgen_receptor	69,86	Androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	resistance|compound|START_ENTITY associated|nsubj|resistance associated|nmod|abnormality abnormality|nmod|END_ENTITY	Androgen resistance associated with a qualitative abnormality of the androgen_receptor and responsive to high dose androgen therapy .
3260889	0	Androgen	0,8	androgen_receptor	45,62	Androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	START_ENTITY|dep|evidence evidence|nmod|END_ENTITY	Androgen and erythropoiesis : evidence for an androgen_receptor in erythroblasts from human bone marrow cultures .
3734664	0	Androgen	0,8	androgen_receptor	27,44	Androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Androgen regulation of the androgen_receptor of the quail uropygial gland : application of a -LSB- 3H -RSB- mibolerone exchange assay .
6606427	0	Androgen	0,8	androgen_receptor	33,50	Androgen	androgen receptor	CHEBI:50113	24208(Tax:10116)	Chemical	Gene	elevation|compound|START_ENTITY elevation|nmod|levels levels|compound|END_ENTITY	Androgen stimulated elevation in androgen_receptor levels is inhibited by the synthetic glucocorticoid_triamcinolone_acetonide .
7376216	0	Androgen	0,8	androgen_receptor	23,40	Androgen	androgen receptor	CHEBI:50113	24208(Tax:10116)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|content content|compound|END_ENTITY	Androgen regulation of androgen_receptor content and distribution in the ventral and dorsolateral prostates of aging AXC rats .
7530286	0	Androgen	0,8	androgen_receptor	129,146	Androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	responsiveness|compound|START_ENTITY responsiveness|dep|regulation regulation|nmod|END_ENTITY	Androgen and oestrogen responsiveness of stromal cells derived from the human hyperplastic prostate : oestrogen regulation of the androgen_receptor .
7606741	0	Androgen	0,8	androgen_receptor	126,143	Androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	up-regulates|compound|START_ENTITY epidermal_growth_factor_receptor|nsubj|up-regulates epidermal_growth_factor_receptor|dobj|affinity affinity|acl|expressing expressing|dobj|END_ENTITY	Androgen up-regulates epidermal_growth_factor_receptor expression and binding affinity in PC3 cell lines expressing the human androgen_receptor .
8824893	0	Androgen	0,8	androgen_receptor	42,59	Androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Androgen and glucocorticoid regulation of androgen_receptor cDNA expression .
8977630	0	Androgen	0,8	androgen_receptor	109,126	Androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	independence|compound|START_ENTITY associated|nsubjpass|independence associated|nmod|down-regulation down-regulation|nmod|expression expression|compound|END_ENTITY	Androgen independence of primary epithelial cultures of the prostate is associated with a down-regulation of androgen_receptor gene expression .
9201706	0	Androgen	0,8	androgen_receptor	45,62	Androgen	androgen receptor	CHEBI:50113	24208(Tax:10116)	Chemical	Gene	deprivation|compound|START_ENTITY causes|nsubj|deprivation causes|dobj|up-regulation up-regulation|nmod|transcript transcript|compound|END_ENTITY	Androgen deprivation causes up-regulation of androgen_receptor transcript in the rat prostate .
23447569	0	Androgen	0,8	b-catenin	19,28	Androgen	b-catenin	CHEBI:50113	1499	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Androgen activates b-catenin signaling in bladder_cancer cells .
3396859	0	Androgen	0,8	beta-glucuronidase	30,48	Androgen	beta-glucuronidase	CHEBI:50113	110006(Tax:10090)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Androgen regulation of murine beta-glucuronidase expression : identification and characterization of a nonresponse variant .
9514151	0	Androgen	0,8	beta-glucuronidase	40,58	Androgen	beta-glucuronidase	CHEBI:50113	110006(Tax:10090)	Chemical	Gene	responsiveness|compound|START_ENTITY responsiveness|nmod|END_ENTITY	Androgen responsiveness of mouse kidney beta-glucuronidase requires 5 ' - flanking and intragenic Gus-s sequences .
19880806	0	Androgen	0,8	brain-derived_neurotrophic_factor	19,52	Androgen	brain-derived neurotrophic factor	CHEBI:50113	627	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Androgen regulates brain-derived_neurotrophic_factor in spinal motoneurons and their target musculature .
23512738	0	Androgen	0,8	brain-derived_neurotrophic_factor	52,85	Androgen	brain-derived neurotrophic factor	CHEBI:50113	24225(Tax:10116)	Chemical	Gene	action|compound|START_ENTITY regulates|nsubj|action regulates|dobj|protein protein|amod|END_ENTITY	Androgen action at the target musculature regulates brain-derived_neurotrophic_factor protein in the spinal_nucleus_of_the_bulbocavernosus .
3129039	0	Androgen	0,8	carbonic_anhydrase_II	23,44	Androgen	carbonic anhydrase II	CHEBI:50113	54231(Tax:10116)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Androgen regulation of carbonic_anhydrase_II , a major soluble protein in rat lateral prostate tissue .
8159272	0	Androgen	0,8	corticotropin-releasing_hormone	48,79	Androgen	corticotropin-releasing hormone	CHEBI:50113	81648(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Androgen inhibits the increases in hypothalamic corticotropin-releasing_hormone -LRB- CRH -RRB- and CRH-immunoreactivity following gonadectomy .
18706413	0	Androgen	0,8	corticotropin-releasing_hormone_receptor_2	23,65	Androgen	corticotropin-releasing hormone receptor 2	CHEBI:50113	64680(Tax:10116)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Androgen regulation of corticotropin-releasing_hormone_receptor_2 -LRB- CRHR2 -RRB- mRNA expression and receptor binding in the rat brain .
15659706	0	Androgen	0,8	cyclin_D2	39,48	Androgen	cyclin D2	CHEBI:50113	64033(Tax:10116)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Androgen regulation of stage-dependent cyclin_D2 expression in Sertoli cells suggests a role in modulating androgen action on spermatogenesis .
7606741	0	Androgen	0,8	epidermal_growth_factor_receptor	22,54	Androgen	epidermal growth factor receptor	CHEBI:50113	1956	Chemical	Gene	up-regulates|compound|START_ENTITY END_ENTITY|nsubj|up-regulates	Androgen up-regulates epidermal_growth_factor_receptor expression and binding affinity in PC3 cell lines expressing the human androgen_receptor .
16873375	0	Androgen	0,8	ezrin	67,72	Androgen	ezrin	CHEBI:50113	7430	Chemical	Gene	induction|compound|START_ENTITY mediated|nsubjpass|induction mediated|nmod|END_ENTITY	Androgen induction of prostate_cancer cell invasion is mediated by ezrin .
14701939	0	Androgen	0,8	follicle-stimulating_hormone_beta	19,52	Androgen	follicle-stimulating hormone beta	CHEBI:50113	14308(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Androgen regulates follicle-stimulating_hormone_beta gene expression in an activin-dependent manner in immortalized gonadotropes .
17975004	0	Androgen	0,8	four_and_a_half_LIM_domain_protein-2	56,92	Androgen	four and a half LIM domain protein-2	CHEBI:50113	2274	Chemical	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	Androgen induction of the androgen_receptor coactivator four_and_a_half_LIM_domain_protein-2 : evidence for a role for serum_response_factor in prostate_cancer .
25247470	0	Androgen	0,8	foxp1	23,28	Androgen	foxp1	CHEBI:50113	297480(Tax:10116)	Chemical	Gene	modulation|compound|START_ENTITY modulation|nmod|END_ENTITY	Androgen modulation of foxp1 and foxp2 in the developing rat brain : impact on sex specific vocalization .
2111188	0	Androgen	0,8	gonadotropin-releasing_hormone	84,114	Androgen	gonadotropin-releasing hormone	CHEBI:50113	25194(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|administration administration|amod|END_ENTITY	Androgen selectively stimulates follicle-stimulating_hormone-beta mRNA levels after gonadotropin-releasing_hormone antagonist administration .
8918677	0	Androgen	0,8	gonadotropin-releasing_hormone	55,85	Androgen	gonadotropin-releasing hormone	CHEBI:50113	2796	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|neurons neurons|acl|containing containing|dobj|END_ENTITY	Androgen regulation of hypothalamic neurons containing gonadotropin-releasing_hormone in a cichlid fish : integration with social cues .
8990630	0	Androgen	0,8	granulocyte_colony-stimulating_factor	37,74	Androgen	granulocyte colony-stimulating factor	CHEBI:50113	1440	Chemical	Gene	therapy|compound|START_ENTITY therapy|nmod|END_ENTITY	Androgen therapy in combination with granulocyte_colony-stimulating_factor and erythropoietin in a patient with refractory_anemia .
2565228	0	Androgen	0,8	hCG	57,60	Androgen	hCG	CHEBI:50113	3342	Chemical	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	Androgen and oestrogen response to a single injection of hCG in cryptorchid horses .
14716763	0	Androgen	0,8	hTERT	98,103	Androgen	hTERT	CHEBI:50113	7015	Chemical	Gene	therapy|compound|START_ENTITY suppresses|nsubj|therapy suppresses|dobj|END_ENTITY	Androgen ablation therapy for prostate_carcinoma suppresses the immunoreactive telomerase subunit hTERT .
1825813	0	Androgen	0,8	insulin	51,58	Androgen	insulin	CHEBI:50113	3630	Chemical	Gene	responses|compound|START_ENTITY increased|nsubj|responses increased|dobj|levels levels|compound|END_ENTITY	Androgen responses to acutely increased endogenous insulin levels in hyperandrogenic and normal cycling women .
2146285	0	Androgen	0,8	insulin	32,39	Androgen	insulin	CHEBI:50113	3630	Chemical	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	Androgen response to endogenous insulin secretion during the frequently sampled intravenous glucose tolerance test in normal and hyperandrogenic women .
15985623	0	Androgen	0,8	insulin-degrading_enzyme	47,71	Androgen	insulin-degrading enzyme	CHEBI:50113	25700(Tax:10116)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Androgen - and estrogen-dependent regulation of insulin-degrading_enzyme in subcellular fractions of rat prostate and uterus .
7947351	0	Androgen	0,8	insulin-like_growth_factor-I	27,55	Androgen	insulin-like growth factor-I	CHEBI:50113	24482(Tax:10116)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Androgen regulation of the insulin-like_growth_factor-I and the estrogen receptor in rat uterus and liver .
8254294	0	Androgen	0,8	insulin-like_growth_factor-I	35,63	Androgen	insulin-like growth factor-I	CHEBI:50113	16000(Tax:10090)	Chemical	Gene	regulation|compound|START_ENTITY regulation|acl|circulating circulating|dobj|END_ENTITY	Androgen regulation of circulating insulin-like_growth_factor-I during puberty in male hypogonadal mice .
8344190	0	Androgen	0,8	insulin-like_growth_factor-I	68,96	Androgen	insulin-like growth factor-I	CHEBI:50113	3479	Chemical	Gene	induction|compound|START_ENTITY mediated|nsubjpass|induction mediated|nmod|END_ENTITY	Androgen induction of steroid 5_alpha-reductase may be mediated via insulin-like_growth_factor-I .
18475631	0	Androgen	0,8	interleukin-1	38,51	Androgen	interleukin-1	CHEBI:50113	3552	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|nmod|synthesis synthesis|amod|END_ENTITY	Androgen metabolism and inhibition of interleukin-1 synthesis in primary cultured human synovial macrophages .
14532843	0	Androgen	0,8	interleukin-6	66,79	Androgen	interleukin-6	CHEBI:50113	3569	Chemical	Gene	dependent|amod|START_ENTITY regulation|amod|dependent induced|nsubj|regulation induced|dobj|expression expression|amod|END_ENTITY	Androgen dependent regulation of bacillus Calmette-Guerin induced interleukin-6 expression in human transitional carcinoma cell lines .
8607856	0	Androgen	0,8	keratinocyte_growth_factor	31,57	Androgen	keratinocyte growth factor	CHEBI:50113	29348(Tax:10116)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Androgen regulation of the rat keratinocyte_growth_factor -LRB- KGF/FGF7 -RRB- promoter .
11282290	0	Androgen	0,8	ornithine_decarboxylase	37,60	Androgen	ornithine decarboxylase	CHEBI:50113	18263(Tax:10090)	Chemical	Gene	stimulation|compound|START_ENTITY stimulation|nmod|activity activity|amod|END_ENTITY	Androgen and estrogen stimulation of ornithine_decarboxylase activity in mouse kidney .
3678932	0	Androgen	0,8	ornithine_decarboxylase	23,46	Androgen	ornithine decarboxylase	CHEBI:50113	24609(Tax:10116)	Chemical	Gene	modulation|compound|START_ENTITY modulation|nmod|growth growth|amod|END_ENTITY	Androgen modulation of ornithine_decarboxylase and compensatory renal growth .
6682754	0	Androgen	0,8	ornithine_decarboxylase	38,61	Androgen	ornithine decarboxylase	CHEBI:50113	18263(Tax:10090)	Chemical	Gene	stimulation|compound|START_ENTITY stimulation|nmod|activity activity|amod|END_ENTITY	Androgen and progestin stimulation of ornithine_decarboxylase activity in the mouse kidney .
8878500	0	Androgen	0,8	ornithine_decarboxylase	17,40	Androgen	ornithine decarboxylase	CHEBI:50113	4953	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Androgen induces ornithine_decarboxylase gene expression in colonic cell line HT-29 .
9108313	0	Androgen	0,8	ornithine_decarboxylase	23,46	Androgen	ornithine decarboxylase	CHEBI:50113	4953	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Androgen regulation of ornithine_decarboxylase in human prostatic cells identified using differential display .
9570735	0	Androgen	0,8	ornithine_decarboxylase	33,56	Androgen	ornithine decarboxylase	CHEBI:50113	4953	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|promoter promoter|compound|END_ENTITY	Androgen regulation of the human ornithine_decarboxylase promoter in prostate_cancer cells .
17189957	0	Androgen	0,8	osteoprotegerin	19,34	Androgen	osteoprotegerin	CHEBI:50113	4982	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|compound|END_ENTITY	Androgen decreases osteoprotegerin expression in prostate_cancer cells .
27015557	0	Androgen	0,8	osteoprotegerin	153,168	Androgen	osteoprotegerin	CHEBI:50113	4982	Chemical	Gene	therapy|compound|START_ENTITY sensitizes|nsubj|therapy sensitizes|nmod|modulation modulation|nmod|END_ENTITY	Androgen deprivation therapy sensitizes triple negative breast_cancer cells to immune-mediated lysis through androgen_receptor independent modulation of osteoprotegerin .
12435483	0	Androgen	0,8	p130	17,21	Androgen	p130	CHEBI:50113	81758(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Androgen induces p130 mRNA expression in the neonatal rat hypothalamus .
10473102	0	Androgen	0,8	p27Kip1	85,92	Androgen	p27Kip1	CHEBI:50113	1027	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|dobj|END_ENTITY	Androgen and epidermal_growth_factor down-regulate cyclin-dependent kinase inhibitor p27Kip1 and costimulate proliferation of MDA PCa_2a and MDA_PCa_2b prostate_cancer cells .
1544711	0	Androgen	0,8	prolactin-receptor	23,41	Androgen	prolactin-receptor	CHEBI:50113	5618	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Androgen regulation of prolactin-receptor gene expression in MCF-7 and MDA-MB-453 human breast_cancer cells .
2523303	0	Androgen	0,8	proopiomelanocortin	23,42	Androgen	proopiomelanocortin	CHEBI:50113	24664(Tax:10116)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Androgen regulation of proopiomelanocortin gene expression and peptide content in the basal hypothalamus .
16541421	0	Androgen	0,8	prostasin	23,32	Androgen	prostasin	CHEBI:50113	5652	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Androgen regulation of prostasin gene expression is mediated by sterol-regulatory element-binding proteins and SLUG .
15882729	0	Androgen	0,8	prostate-specific_antigen	90,115	Androgen	prostate-specific antigen	CHEBI:50113	354	Chemical	Gene	deprivation|compound|START_ENTITY deprivation|dep|threshold threshold|acl|achieving achieving|dobj|END_ENTITY	Androgen deprivation for minimal metastatic disease : threshold for achieving undetectable prostate-specific_antigen .
11870804	0	Androgen	0,8	spermidine_synthase	23,42	Androgen	spermidine synthase	CHEBI:50113	84596(Tax:10116)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Androgen regulation of spermidine_synthase expression in the rat prostate .
17131419	0	Androgen	0,8	trkB	19,23	Androgen	trkB	CHEBI:50113	4915	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Androgen regulates trkB immunolabeling in spinal motoneurons .
23369005	0	Androgen	0,8	vascular_endothelial_growth_factor	22,56	Androgen	vascular endothelial growth factor	CHEBI:50113	7422	Chemical	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|compound|END_ENTITY	Androgen up-regulates vascular_endothelial_growth_factor expression in prostate_cancer cells via an Sp1 binding site .
14726521	0	Androgens	0,9	FKHR	60,64	Androgens	FKHR	MESH:D000728	2308	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	Androgens negatively regulate forkhead transcription factor FKHR -LRB- FOXO1 -RRB- through a proteolytic mechanism in prostate_cancer cells .
25631036	0	Androgens	0,9	SMAD_ubiquitination_regulatory_factor-1	19,58	Androgens	SMAD ubiquitination regulatory factor-1	MESH:D000728	57154	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|compound|END_ENTITY	Androgens regulate SMAD_ubiquitination_regulatory_factor-1 expression and prostate_cancer cell invasion .
14686649	0	Androgens	0,9	androgen_receptor	25,42	Androgens	androgen receptor	MESH:D000728	367	Chemical	Gene	affect|nsubj|START_ENTITY affect|dobj|distribution distribution|compound|END_ENTITY	Androgens and FSH affect androgen_receptor and aromatase distribution in the porcine ovary .
16866309	0	Androgens	0,9	androgen_receptor	62,79	Androgens	androgen receptor	MESH:D000728	397582(Tax:9823)	Chemical	Gene	START_ENTITY|dep|actions actions|acl|mediated mediated|nmod|END_ENTITY	Androgens in female pig reproduction : actions mediated by the androgen_receptor .
17079484	0	Androgens	0,9	androgen_receptor	73,90	Androgens	androgen receptor	MESH:D000728	367	Chemical	Gene	modulate|nsubj|START_ENTITY modulate|dobj|expression expression|nmod|transcription_intermediary_factor_2 transcription_intermediary_factor_2|appos|coactivator coactivator|compound|END_ENTITY	Androgens modulate expression of transcription_intermediary_factor_2 , an androgen_receptor coactivator whose expression level correlates with early biochemical recurrence in prostate_cancer .
19100835	0	Androgens	0,9	androgen_receptor	18,35	Androgens	androgen receptor	MESH:D000728	367	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|activation activation|compound|END_ENTITY	Androgens inhibit androgen_receptor promoter activation in motor neurons .
19383315	0	Androgens	0,9	androgen_receptor	158,175	Androgens	androgen receptor	MESH:D000728	367	Chemical	Gene	act|nsubj|START_ENTITY act|xcomp|enhance enhance|xcomp|10 10|nmod|cells cells|nmod|END_ENTITY	Androgens act synergistically to enhance estrogen-induced upregulation of human tissue kallikreins 10 , 11 , and 14 in breast_cancer cells via a membrane bound androgen_receptor .
25864624	0	Androgens	0,9	androgen_receptor	92,109	Androgens	androgen receptor	MESH:D000728	367	Chemical	Gene	induce|compound|START_ENTITY sebaceous|nsubj|induce sebaceous|nmod|cells cells|acl|expressing expressing|dobj|END_ENTITY	Androgens induce sebaceous differentiation in sebocyte cells expressing a stable functional androgen_receptor .
26862856	0	Androgens	0,9	androgen_receptor	99,116	Androgens	androgen receptor	MESH:D000728	367	Chemical	Gene	downregulate|nsubj|START_ENTITY downregulate|nmod|cells cells|acl|underlining underlining|dobj|role role|nmod|END_ENTITY	Androgens downregulate miR-21 expression in breast_cancer cells underlining the protective role of androgen_receptor .
8639466	0	Androgens	0,9	androgen_receptor	43,60	Androgens	androgen receptor	MESH:D000728	24208(Tax:10116)	Chemical	Gene	down-regulators|nsubj|START_ENTITY down-regulators|nmod|levels levels|compound|END_ENTITY	Androgens are not major down-regulators of androgen_receptor levels during growth of the immature rat penis .
17049502	0	Androgens	0,9	angiotensin_II	49,63	Androgens	angiotensin II	MESH:D000728	24179(Tax:10116)	Chemical	Gene	potentiate|nsubj|START_ENTITY potentiate|nmod|END_ENTITY	Androgens potentiate renal vascular responses to angiotensin_II via amplification of the Rho kinase signaling pathway .
9067276	0	Androgens	0,9	fatty_acid_synthase	20,39	Androgens	fatty acid synthase	MESH:D000728	2194	Chemical	Gene	stimulate|nsubj|START_ENTITY stimulate|dobj|END_ENTITY	Androgens stimulate fatty_acid_synthase in the human prostate_cancer cell line LNCaP .
18647804	0	Androgens	0,9	growth_hormone	108,122	Androgens	growth hormone	MESH:D000728	2688	Chemical	Gene	mediate|nsubj|START_ENTITY mediate|nmod|secretion secretion|compound|END_ENTITY	Androgens may mediate a relative preservation of IGF-I levels in overweight and obese women despite reduced growth_hormone secretion .
16117808	0	Androgens	0,9	insulin	11,18	Androgens	insulin	MESH:D000728	3630	Chemical	Gene	START_ENTITY|appos|resistance resistance|compound|END_ENTITY	Androgens , insulin resistance and vascular_disease in men .
10397515	0	Androgens	0,9	interleukin-6	19,32	Androgens	interleukin-6	MESH:D000728	3569	Chemical	Gene	modulate|nsubj|START_ENTITY modulate|dobj|production production|amod|END_ENTITY	Androgens modulate interleukin-6 production by gingival fibroblasts in vitro .
17658471	0	Androgens	0,9	myostatin	30,39	Androgens	myostatin	MESH:D000728	29152(Tax:10116)	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|compound|END_ENTITY	Androgens negatively regulate myostatin expression in an androgen-dependent skeletal muscle .
18346198	0	Androgens	0,9	neprilysin	19,29	Androgens	neprilysin	MESH:D000728	24590(Tax:10116)	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|compound|END_ENTITY	Androgens regulate neprilysin expression : role in reducing beta-amyloid levels .
14764637	0	Androgens	0,9	phosphodiesterase_type_5	19,43	Androgens	phosphodiesterase type 5	MESH:D000728	8654	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|amod|END_ENTITY	Androgens regulate phosphodiesterase_type_5 expression and functional activity in corpora cavernosa .
8288699	0	Androgens	0,9	prolactin	17,26	Androgens	prolactin	MESH:D000728	5617	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|production production|compound|END_ENTITY	Androgens induce prolactin production by human endometrial stromal cells in vitro .
21491909	0	Andrographolide	0,15	ICAM-1	25,31	Andrographolide	ICAM-1	MESH:C030419	3383	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Andrographolide inhibits ICAM-1 expression and NF-kB activation in TNF-a-treated EA.hy926 cells .
24998495	0	Andrographolide	0,15	ICAM-1	38,44	Andrographolide	ICAM-1	MESH:C030419	15894(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Andrographolide inhibits TNFa-induced ICAM-1 expression via suppression of NADPH oxidase activation and induction of HO-1 and GCLM expression through the PI3K/Akt/Nrf2 and PI3K/Akt/AP -1 pathways in human endothelial cells .
15931581	0	Andrographolide	0,15	IFN-gamma	25,34	Andrographolide	IFN-gamma	MESH:C030419	15978(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Andrographolide inhibits IFN-gamma and IL-2 cytokine production and protects against cell apoptosis .
19038244	0	Andrographolide	0,15	IL-2	24,28	Andrographolide	IL-2	MESH:C030419	3558	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|production production|compound|END_ENTITY	Andrographolide reduces IL-2 production in T-cells by interfering with NFAT and MAPK activation .
17943075	0	Andrographolide	0,15	NF-kappaBeta	25,37	Andrographolide	NF-kappaBeta	MESH:C030419	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	Andrographolide inhibits NF-kappaBeta activation and attenuates neointimal_hyperplasia in arterial_restenosis .
21512969	0	Andrographolide	0,15	NOX2	44,48	Andrographolide	NOX2	MESH:C030419	13058(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Andrographolide inhibits PI3K/AKT-dependent NOX2 and iNOS expression protecting mice against hypoxia/ischemia-induced oxidative brain_injury .
16462022	0	Andrographolide	0,15	TNF-alpha	43,52	Andrographolide	TNF-alpha	MESH:C030419	21926(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|nmod|END_ENTITY	Andrographolide inhibits the production of TNF-alpha and interleukin-12 in lipopolysaccharide-stimulated macrophages : role of mitogen-activated protein kinases .
21779488	0	Andrographolide	0,15	androgen_receptor	24,41	Andrographolide	androgen receptor	MESH:C030419	367	Chemical	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	Andrographolide targets androgen_receptor pathway in castration-resistant_prostate_cancer .
17918040	0	Andrographolide	0,15	c-Jun_N-terminal_kinase	92,115	Andrographolide	c-Jun N-terminal kinase	MESH:C030419	5599	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|activation activation|nmod|END_ENTITY	Andrographolide inhibits human hepatoma-derived Hep3B cell growth through the activation of c-Jun_N-terminal_kinase .
21925256	0	Andrographolide	0,15	cytochrome_P450_3A4	66,85	Andrographolide	cytochrome P450 3A4	MESH:C030419	1576	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	Andrographolide inhibits the expression and metabolic activity of cytochrome_P450_3A4 in the modified Caco-2 cells .
23629921	0	Andrographolide	0,15	heme_oxygenase-1	97,113	Andrographolide	heme oxygenase-1	MESH:C030419	15368(Tax:10090)	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|activation activation|nmod|END_ENTITY	Andrographolide protects against cigarette smoke-induced lung_inflammation through activation of heme_oxygenase-1 .
25709476	0	Andrographolide	0,15	hypoxia-inducible_factor-1	25,51	Andrographolide	hypoxia-inducible factor-1	MESH:C030419	3091	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Andrographolide inhibits hypoxia-inducible_factor-1 through phosphatidylinositol_3-kinase / AKT pathway and suppresses breast_cancer growth .
9786505	0	Andrographolide	0,15	inducible_nitric_oxide_synthase	45,76	Andrographolide	inducible nitric oxide synthase	MESH:C030419	24599(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|nmod|END_ENTITY	Andrographolide suppresses the expression of inducible_nitric_oxide_synthase in macrophage and restores the vasoconstriction in rat aorta treated with lipopolysaccharide .
21442031	0	Andrographolide	0,15	interleukin-6	46,59	Andrographolide	interleukin-6	MESH:C030419	3569	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Andrographolide , an herbal medicine , inhibits interleukin-6 expression and suppresses prostate_cancer cell growth .
22804248	0	Andrographolide	0,15	osteopontin	25,36	Andrographolide	osteopontin	MESH:C030419	6696	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Andrographolide inhibits osteopontin expression and breast_tumor growth through down regulation of PI3 kinase/Akt signaling pathway .
26829328	0	Androstane	75,85	Pregnane_X_Receptor	110,129	Androstane	Pregnane X Receptor	MESH:C033936	8856	Chemical	Gene	Receptor|compound|START_ENTITY Receptor|nmod|END_ENTITY	Correction : Structural and Functional Similarity of Amphibian Constitutive Androstane Receptor with Mammalian Pregnane_X_Receptor .
23926521	0	Androstenedione	69,84	Cx43	14,18	Androstenedione	Cx43	MESH:D000735	24392(Tax:10116)	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|END_ENTITY	Modulation of Cx43 and Gap Junctional Intercellular Communication by Androstenedione in Rat Polycystic_Ovary and Granulosa Cells in vitro .
25590624	0	Androstenone	14,26	3b-Hydroxysteroid_Dehydrogenase	118,149	Androstenone	3b-Hydroxysteroid Dehydrogenase	CHEBI:37894	445539(Tax:9823)	Chemical	Gene	Metabolism|nmod|START_ENTITY Metabolism|nmod|END_ENTITY	Metabolism of Androstenone , 17b-Estradiol and Dihydrotestosterone in Primary Cultured Pig Hepatocytes and the Role of 3b-Hydroxysteroid_Dehydrogenase in This Process .
11549292	0	Angiogenin	0,10	Erk1/2	21,27	Angiogenin	Erk1/2	null	5595;5594	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Angiogenin activates Erk1/2 in human umbilical vein endothelial cells .
22266868	0	Angiogenin	0,10	p53	39,42	Angiogenin	p53	null	7157	Chemical	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Angiogenin functionally interacts with p53 and regulates p53-mediated apoptosis and cell survival .
2646638	0	Angiogenin	0,10	phospholipase_A2	79,95	Angiogenin	phospholipase A2	null	151056	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|activation activation|nmod|END_ENTITY	Angiogenin stimulates endothelial cell prostacyclin secretion by activation of phospholipase_A2 .
23220260	0	Angiostatin	0,11	MMP-2	33,38	Angiostatin	MMP-2	MESH:D043168	4313	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Angiostatin inhibits endothelial MMP-2 and MMP-14 expression : a hypoxia specific mechanism of action .
10986284	0	Angiostatin	0,11	cathepsin_D	26,37	Angiostatin	cathepsin D	MESH:D043168	1509	Chemical	Gene	generation|compound|START_ENTITY generation|nmod|END_ENTITY	Angiostatin generation by cathepsin_D secreted by human prostate_carcinoma cells .
9332716	0	Angiotensin	0,11	AT2	23,26	Angiotensin	AT2	MESH:D000809	24182(Tax:10116)	Chemical	Gene	type-2|compound|START_ENTITY type-2|appos|END_ENTITY	Angiotensin II type-2 -LRB- AT2 -RRB- receptor-mediated inhibition of NMDA receptor signalling in neuronal cells .
10712283	0	Angiotensin	0,11	TGF-beta1	23,32	Angiotensin	TGF-beta1	MESH:D000809	59086(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Angiotensin stimulates TGF-beta1 and clusterin in the hydronephrotic neonatal rat kidney .
2893620	0	Angiotensin	0,11	aminopeptidase_A	49,65	Angiotensin	aminopeptidase A	MESH:D000809	2028	Chemical	Gene	metabolism|nsubj|START_ENTITY metabolism|nmod|END_ENTITY	Angiotensin metabolism by cerebral microvascular aminopeptidase_A .
10027863	0	Angiotensin	0,11	angiotensin_II	40,54	Angiotensin	angiotensin II	MESH:D000809	24179(Tax:10116)	Chemical	Gene	enhancement|amod|START_ENTITY enhancement|compound|END_ENTITY	Angiotensin receptor subtype 1 mediates angiotensin_II enhancement of isoproterenol-induced cyclic_AMP production in preglomerular microvascular smooth muscle cells .
23524303	0	Angiotensin	0,11	angiotensin_II	53,67	Angiotensin	angiotensin II	MESH:D000809	183	Chemical	Gene	counteracts|nsubj|START_ENTITY counteracts|dobj|effect effect|nmod|END_ENTITY	Angiotensin -LRB- 1-7 -RRB- counteracts the negative effect of angiotensin_II on insulin signalling in HUVECs .
19414647	0	Angiotensin	61,72	hemopexin	87,96	Angiotensin	hemopexin	MESH:D000809	3263	Chemical	Gene	receptor|compound|START_ENTITY receptor|nmod|END_ENTITY	Vascular_contraction and preeclampsia : downregulation of the Angiotensin receptor 1 by hemopexin in vitro .
17065573	0	Angiotensin	18,29	renin	12,17	Angiotensin	renin	MESH:D000809	5972	Chemical	Gene	system|compound|START_ENTITY system|compound|END_ENTITY	Circulating renin Angiotensin system in childhood chronic_renal_failure : marked increase of Angiotensin - -LRB- 1-7 -RRB- in end-stage renal_disease .
17065573	0	Angiotensin	92,103	renin	12,17	Angiotensin	renin	MESH:D000809	5972	Chemical	Gene	increase|nmod|START_ENTITY system|dep|increase system|compound|END_ENTITY	Circulating renin Angiotensin system in childhood chronic_renal_failure : marked increase of Angiotensin - -LRB- 1-7 -RRB- in end-stage renal_disease .
24390237	0	AngiotensinII	0,13	HuR	22,25	AngiotensinII	HuR	MESH:D000804	1994	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	AngiotensinII induces HuR shuttling by post-transcriptional regulated CyclinD1 in human mesangial cells .
9220359	0	Angiotensin_I	0,13	angiotensin_II	70,84	Angiotensin I	angiotensin II	MESH:D000803	24179(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	Angiotensin_I modulates Ca-transport systems in the rat heart through angiotensin_II .
9892157	1	Angiotensin_II	63,77	renin	185,190	Angiotensin II	AngII	MESH:D000804	183	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|nmod|END_ENTITY	Angiotensin_II -LRB- AngII -RRB- resulting as the end product of a proteolytic cascade initiated by renin inhibits the secretion of renin in the sense of a negative feedback .
21477268	0	Angiotensin_IV	0,14	IRAP	87,91	Angiotensin IV	IRAP	MESH:C012877	4012	Chemical	Gene	displays|nsubj|START_ENTITY displays|dobj|affinity affinity|nmod|insulin-regulated_aminopeptidase insulin-regulated_aminopeptidase|appos|END_ENTITY	Angiotensin_IV displays only low affinity for native insulin-regulated_aminopeptidase -LRB- IRAP -RRB- .
25451332	0	Angiotensin_IV	0,14	insulin_regulated_aminopeptidase	72,104	Angiotensin IV	insulin regulated aminopeptidase	MESH:C012877	4012	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|nmod|END_ENTITY	Angiotensin_IV stimulates high atrial stretch-induced ANP secretion via insulin_regulated_aminopeptidase .
10432384	0	Angiotensin_IV	0,14	plasminogen_activator_inhibitor-1	26,59	Angiotensin IV	plasminogen activator inhibitor-1	MESH:C012877	5054	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Angiotensin_IV stimulates plasminogen_activator_inhibitor-1 expression in proximal tubular epithelial cells .
20579875	0	Anibamine	0,9	CCR5	29,33	Anibamine	CCR5	MESH:C488244	12774(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Anibamine , a natural product CCR5 antagonist , as a novel lead for the development of anti-prostate_cancer agents .
26914232	0	Anilide	59,66	CO2	77,80	Anilide	CO2	CHEBI:13248	717	Chemical	Gene	Ions|compound|START_ENTITY Ions|nmod|END_ENTITY	Formation of Carbamate Anions by the Gas-phase Reaction of Anilide Ions with CO2 .
16279804	0	Anilinodialkoxyquinazolines	0,27	epidermal_growth_factor_receptor	39,71	Anilinodialkoxyquinazolines	epidermal growth factor receptor	null	13649(Tax:10090)	Chemical	Gene	START_ENTITY|dep|inhibitors inhibitors|compound|END_ENTITY	Anilinodialkoxyquinazolines : screening epidermal_growth_factor_receptor tyrosine kinase inhibitors for potential tumor imaging probes .
12941317	0	Anilinopyrazole	0,15	CDK2	29,33	Anilinopyrazole	CDK2	null	1017	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Anilinopyrazole as selective CDK2 inhibitors : design , synthesis , biological evaluation , and X-ray crystallographic analysis .
24944742	0	Anilinopyrimidines	13,31	c-Met	54,59	Anilinopyrimidines	c-Met	null	4233	Chemical	Gene	START_ENTITY|nmod|Inhibitors Inhibitors|nmod|END_ENTITY	Discovery of Anilinopyrimidines as Dual Inhibitors of c-Met and VEGFR-2 : Synthesis , SAR , and Cellular Activity .
25171422	0	Anisomycin	0,10	CA3	29,32	Anisomycin	CA3	MESH:D000841	761	Chemical	Gene	injection|compound|START_ENTITY injection|nmod|END_ENTITY	Anisomycin injection in area CA3 of the hippocampus impairs both short-term and long-term memories of contextual fear .
16054711	0	Anisomycin	0,10	COX-2	19,24	Anisomycin	COX-2	MESH:D000841	26198(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Anisomycin induces COX-2 mRNA expression through p38 -LRB- MAPK -RRB- and CREB independent of small GTPases in intestinal epithelial cells .
16054711	0	Anisomycin	0,10	p38	49,52	Anisomycin	p38	MESH:D000841	81649(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Anisomycin induces COX-2 mRNA expression through p38 -LRB- MAPK -RRB- and CREB independent of small GTPases in intestinal epithelial cells .
16581040	0	Anisomycin	0,10	p38	21,24	Anisomycin	p38	MESH:D000841	26416(Tax:10090)	Chemical	Gene	MAP|compound|START_ENTITY MAP|compound|END_ENTITY	Anisomycin activates p38 MAP kinase to induce LTD in mouse primary visual cortex .
17391655	0	Anisomycin	0,10	p38	92,95	Anisomycin	p38	MESH:D000841	1432	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|hypoxia hypoxia|nmod|regulation regulation|nmod|END_ENTITY	Anisomycin protects cortical neurons from prolonged hypoxia with differential regulation of p38 and ERK .
23067223	0	Anisomycin	0,10	p38	151,154	Anisomycin	p38	MESH:D000841	1432	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|apoptosis apoptosis|nmod|cells cells|nmod|activation activation|nmod|END_ENTITY	Anisomycin induces apoptosis of glucocorticoid resistant acute_lymphoblastic_leukemia CEM-C1 cells via activation of mitogen-activated protein kinases p38 and JNK .
22982045	0	Ankaflavin	0,10	Nrf-2	20,25	Ankaflavin	Nrf-2	MESH:C499916	18024(Tax:10090)	Chemical	Gene	START_ENTITY|appos|activator activator|compound|END_ENTITY	Ankaflavin , a novel Nrf-2 activator for attenuating allergic airway_inflammation .
1628159	0	Anpirtoline	0,11	5-HT1B_receptor	36,51	Anpirtoline	5-HT1B receptor	MESH:C075631	15551(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Anpirtoline , a novel , highly potent 5-HT1B_receptor agonist with antinociceptive/antidepressant-like actions in rodents .
19860734	0	Ansamycin	0,9	Hsp90	24,29	Ansamycin	Hsp90	MESH:D017828	3320	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|nmod|END_ENTITY	Ansamycin inhibitors of Hsp90 : nature 's prototype for anti-chaperone therapy .
9145778	0	Antazoline	0,10	insulin	21,28	Antazoline	insulin	MESH:D000865	483665(Tax:9615)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|secretion secretion|compound|END_ENTITY	Antazoline increases insulin secretion and improves glucose tolerance in rats and dogs .
24387788	0	Anthocyanidins	11,25	CYP2A6	89,95	Anthocyanidins	CYP2A6	MESH:D000872	1548	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of Anthocyanidins and Anthocyanins on the Expression and Catalytic Activities of CYP2A6 , CYP2B6 , CYP2C9 , and CYP3A4 in Primary Human Hepatocytes and Human Liver Microsomes .
24363205	0	Anthocyanidins	0,14	FAK	22,25	Anthocyanidins	FAK	MESH:D000872	25614(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitors inhibitors|compound|END_ENTITY	Anthocyanidins , novel FAK inhibitors , attenuate PDGF-BB-induced aortic smooth muscle cell migration and neointima formation .
15963474	0	Anthocyanidins	0,14	cyclooxygenase-2	23,39	Anthocyanidins	cyclooxygenase-2	MESH:D000872	19225(Tax:10090)	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|expression expression|amod|END_ENTITY	Anthocyanidins inhibit cyclooxygenase-2 expression in LPS-evoked macrophages : structure-activity relationship and molecular mechanisms involved .
26854848	0	Anthocyanin	23,34	MYBL2	65,70	Anthocyanin	MYBL2	MESH:D000872	843443(Tax:3702)	Chemical	Gene	Biosynthesis|compound|START_ENTITY Biosynthesis|nmod|END_ENTITY	DELLA Proteins Promote Anthocyanin Biosynthesis via Sequestering MYBL2 and JAZ Suppressors of the MYB/bHLH/WD40 Complex in Arabidopsis_thaliana .
24595303	0	Anthocyanin	0,11	adiponectin	22,33	Anthocyanin	adiponectin	MESH:D000872	9370	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|secretion secretion|compound|END_ENTITY	Anthocyanin increases adiponectin secretion and protects against diabetes-related_endothelial_dysfunction .
21762960	0	Anthracycline	0,13	THP-1	66,71	Anthracycline	THP-1	CHEBI:48120	2736	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|END_ENTITY	Anthracycline treatment of the human monocytic_leukemia cell line THP-1 increases phosphatidylserine exposure and tissue factor activity .
24832494	0	Anthracycline	0,13	aldo-keto_reductase_1C3	87,110	Anthracycline	aldo-keto reductase 1C3	CHEBI:48120	8644	Chemical	Gene	resistance|amod|START_ENTITY resistance|dep|role role|nmod|END_ENTITY	Anthracycline resistance mediated by reductive metabolism in cancer cells : the role of aldo-keto_reductase_1C3 .
1314863	0	Anthralin	0,9	TGF-alpha	33,42	Anthralin	TGF-alpha	MESH:D000875	7039	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|amod|END_ENTITY	Anthralin decreases keratinocyte TGF-alpha expression and EGF-receptor binding in vitro .
27093247	0	Anthraquinones	101,115	15-LOX	82,88	Anthraquinones	15-LOX	MESH:D000880	11687(Tax:10090)	Chemical	Gene	Activity|nmod|START_ENTITY Activity|nummod|END_ENTITY	Inhibition of Nitric_Oxide Production in LPS-Stimulated RAW 264.7 Macrophages and 15-LOX Activity by Anthraquinones from Pentas schimperi .
17497420	0	Anthraquinones	0,14	Cdc25B	16,22	Anthraquinones	Cdc25B	MESH:D000880	994	Chemical	Gene	START_ENTITY|appos|inhibitors inhibitors|amod|END_ENTITY	Anthraquinones , Cdc25B phosphatase inhibitors , isolated from the roots of Polygonum multiflorum Thunb .
26133709	0	Anthraquinones	48,62	hOAT1	29,34	Anthraquinones	hOAT1	MESH:D000880	9356	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Time-Dependent Inhibition of hOAT1 and hOAT3 by Anthraquinones .
12842759	0	Antileukinate	30,43	Chemokine_receptor	0,18	Antileukinate	Chemokine receptor	MESH:C118980	7852	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Chemokine_receptor inhibitor , Antileukinate , suppressed ovalbumin-induced eosinophilic_inflammation in the airway .
8988236	0	Antimycin	0,9	cytochrome_b	94,106	Antimycin	cytochrome b	MESH:C032456	4519	Chemical	Gene	resistance|compound|START_ENTITY cytochrome|nsubj|resistance cytochrome|dep|instability instability|acl|associated associated|nmod|mutation mutation|compound|END_ENTITY	Antimycin resistance and ubiquinol cytochrome c reductase instability associated with a human cytochrome_b mutation .
6795595	0	Aphidicolin	0,11	DNA_polymerase_alpha	38,58	Aphidicolin	DNA polymerase alpha	MESH:D016590	5422	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Aphidicolin inhibits DNA synthesis by DNA_polymerase_alpha and isolated nuclei by a similar mechanism .
23019417	0	Apicidin	0,8	CTCFL	52,57	Apicidin	CTCFL	MESH:C102351	140690	Chemical	Gene	drives|nsubj|START_ENTITY drives|dobj|expression expression|amod|END_ENTITY	Apicidin and docetaxel combination treatment drives CTCFL expression and HMGB1 release acting as potential antitumor immune response inducers in metastatic breast_cancer cells .
10893438	0	Apicidin	0,8	histone_deacetylase	26,45	Apicidin	histone deacetylase	MESH:C102351	9734	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Apicidin , an inhibitor of histone_deacetylase , prevents H-ras-induced invasive phenotype .
14985106	0	Apicidin	0,8	histone_deacetylase	14,33	Apicidin	histone deacetylase	MESH:C102351	9734	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|amod|END_ENTITY	Apicidin is a histone_deacetylase inhibitor with anti-invasive and anti-angiogenic potentials .
20428772	0	Apigenin	0,8	Bax	85,88	Apigenin	Bax	MESH:D047310	581	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|pathway pathway|amod|END_ENTITY	Apigenin induces caspase-dependent apoptosis in human lung_cancer A549 cells through Bax - and Bcl-2-triggered mitochondrial pathway .
24958013	0	Apigenin	29,37	COX-2	117,122	Apigenin	COX-2	MESH:D047310	19225(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Anti-Inflammatory Effects of Apigenin in Lipopolysaccharide-Induced Inflammatory in Acute_Lung_Injury by Suppressing COX-2 and NF-kB Pathway .
26802941	0	Apigenin	0,8	COX-2	18,23	Apigenin	COX-2	MESH:D047310	19225(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Apigenin inhibits COX-2 , PGE2 , and EP1 and also initiates terminal differentiation in the epidermis of tumor bearing mice .
17132221	0	Apigenin	0,8	ERbeta	47,53	Apigenin	ERbeta	MESH:D047310	2100	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	Apigenin suppresses cancer cell growth through ERbeta .
24734099	0	Apigenin	0,8	Epidermal_Growth_Factor_Receptor	30,62	Apigenin	Epidermal Growth Factor Receptor	MESH:D047310	1956	Chemical	Gene	Pathway|compound|START_ENTITY Pathway|compound|END_ENTITY	Apigenin and Wogonin Regulate Epidermal_Growth_Factor_Receptor Signaling Pathway Involved in MUC5AC Mucin Gene Expression and Production from Cultured Airway Epithelial Cells .
18953257	0	Apigenin	0,8	GLUT-1	22,28	Apigenin	GLUT-1	MESH:D047310	6513	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|transporter transporter|compound|END_ENTITY	Apigenin inhibits the GLUT-1 glucose transporter and the phosphoinositide_3-kinase / Akt pathway in human pancreatic_cancer cells .
25120770	0	Apigenin	0,8	GLUT-1	20,26	Apigenin	GLUT-1	MESH:D047310	6513	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Apigenin suppresses GLUT-1 and p-AKT expression to enhance the chemosensitivity to cisplatin of laryngeal_carcinoma Hep-2 cells : an in vitro study .
22527144	0	Apigenin	0,8	IL-6	36,40	Apigenin	IL-6	MESH:D047310	3569	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Apigenin inhibits the expression of IL-6 , IL-8 , and ICAM-1 in DEHP-stimulated human umbilical vein endothelial cells and in vivo .
19447105	0	Apigenin	0,8	Id1	70,73	Apigenin	Id1	MESH:D047310	3397	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Apigenin inhibits proliferation of ovarian_cancer A2780 cells through Id1 .
25489420	0	Apigenin	0,8	Mucin	84,89	Apigenin	Mucin	MESH:D047310	100508689	Chemical	Gene	Production|compound|START_ENTITY Production|nmod|END_ENTITY	Apigenin Inhibits Tumor_Necrosis_Factor-a-Induced Production and Gene Expression of Mucin through Regulating Nuclear Factor-Kappa B Signaling Pathway in Airway Epithelial Cells .
22985621	0	Apigenin	0,8	PKC	40,43	Apigenin	PKC	MESH:D047310	5580	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Apigenin induces DNA damage through the PKC - dependent activation of ATM and H2AX causing down-regulation of genes involved in cell cycle control and DNA repair .
23563034	0	Apigenin	0,8	TGF-b1	18,24	Apigenin	TGF-b1	MESH:D047310	7040	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Apigenin inhibits TGF-b1 induced fibroblast-to-myofibroblast transition in human lung fibroblast populations .
15388333	0	Apigenin	0,8	VEGF	38,42	Apigenin	VEGF	MESH:D047310	7422	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|nmod|END_ENTITY	Apigenin suppresses the expression of VEGF , an important factor for angiogenesis , in endothelial cells via degradation of HIF-1alpha protein .
15746177	0	Apigenin	0,8	VEGF	18,22	Apigenin	VEGF	MESH:D047310	7422	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Apigenin inhibits VEGF and HIF-1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways .
20551847	8	Apigenin	1371,1379	VEGF	1447,1451	Apigenin	VEGF	MESH:D047310	7422	Chemical	Gene	START_ENTITY|acl|prevented prevented|dobj|induction induction|nmod|mRNA mRNA|amod|END_ENTITY	RESULTS : Apigenin -LRB- 50 or 100 microM -RRB- prevented progestin-dependent induction of both VEGF mRNA and protein and reduced progesterone_receptor levels in T47-D cells .
23359392	0	Apigenin	0,8	VEGF	32,36	Apigenin	VEGF	MESH:D047310	7422	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Apigenin inhibits TGF-b-induced VEGF expression in human prostate_carcinoma cells via a Smad2/3 - _ and_Src-dependent mechanism .
24288566	0	Apigenin	19,27	VEGF	64,68	Apigenin	VEGF	MESH:D047310	7422	Chemical	Gene	Expression|compound|START_ENTITY Levels|nmod|Expression Levels|nmod|END_ENTITY	Subtoxic Levels of Apigenin Inhibit Expression and Secretion of VEGF by Uveal_Melanoma Cells via Suppression of ERK1/2 and PI3K/Akt Pathways .
18974065	0	Apigenin	0,8	focal_adhesion_kinase	86,107	Apigenin	focal adhesion kinase	MESH:D047310	5747	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|nmod|END_ENTITY	Apigenin inhibited migration and invasion of human ovarian_cancer A2780 cells through focal_adhesion_kinase .
16109301	0	Apigenin	0,8	heme_oxygenase-1	34,50	Apigenin	heme oxygenase-1	MESH:D047310	15368(Tax:10090)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|induction induction|amod|END_ENTITY	Apigenin decreases hemin-mediated heme_oxygenase-1 induction .
8930885	0	Apigenin	0,8	intercellular_adhesion_molecule-1	48,81	Apigenin	intercellular adhesion molecule-1	MESH:D047310	25464(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|upregulation upregulation|amod|END_ENTITY	Apigenin inhibits tumor_necrosis_factor-induced intercellular_adhesion_molecule-1 upregulation in vivo .
17338120	0	Apigenin	1,9	monocyte_chemoattractant_protein_1	50,84	Apigenin	monocyte chemoattractant protein 1	MESH:D047310	20296(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	-LSB- Apigenin inhibits release and gene expression of monocyte_chemoattractant_protein_1 -LRB- MCP-1 -RRB- in J774 .2 macrophages -RSB- .
23773626	0	Apigenin	0,8	transgelin	22,32	Apigenin	transgelin	MESH:D047310	6876	Chemical	Gene	up-regulates|compound|START_ENTITY END_ENTITY|nsubj|up-regulates	Apigenin up-regulates transgelin and inhibits invasion and migration of colorectal_cancer through decreased phosphorylation of AKT .
15947208	0	Apigenin	0,8	vascular_endothelial_growth_factor	32,66	Apigenin	vascular endothelial growth factor	MESH:D047310	7422	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Apigenin inhibits expression of vascular_endothelial_growth_factor and angiogenesis in human lung_cancer cells : implication of chemoprevention of lung_cancer .
20551847	0	Apigenin	0,8	vascular_endothelial_growth_factor	29,63	Apigenin	vascular endothelial growth factor	MESH:D047310	7422	Chemical	Gene	blocks|nsubj|START_ENTITY blocks|dobj|induction induction|nmod|mRNA mRNA|compound|END_ENTITY	Apigenin blocks induction of vascular_endothelial_growth_factor mRNA and protein in progestin-treated human breast_cancer cells .
18729009	0	Apixaban	0,8	Factor_Xa	49,58	Apixaban	Factor Xa	MESH:C522181	2159	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Apixaban , an oral , direct inhibitor of activated Factor_Xa .
19012508	0	Apixaban	0,8	Factor_Xa	25,34	Apixaban	Factor Xa	MESH:C522181	2159	Chemical	Gene	START_ENTITY|dep|awaiting awaiting|nsubj|inhibitor inhibitor|compound|END_ENTITY	Apixaban , an oral direct Factor_Xa inhibitor : awaiting the verdict .
26749408	0	Apixaban	46,54	Factor_Xa	84,93	Apixaban	Factor Xa	MESH:C522181	2159	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|nmod|END_ENTITY	Effect of Rifampin on the Pharmacokinetics of Apixaban , an Oral Direct Inhibitor of Factor_Xa .
19470889	0	Apixaban	0,8	factor_Xa	37,46	Apixaban	factor Xa	MESH:C522181	2159	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Apixaban , an oral , direct , selective factor_Xa inhibitor , in combination with antiplatelet therapy after acute_coronary_syndrome : results of the Apixaban for Prevention of Acute Ischemic and Safety Events -LRB- APPRAISE -RRB- trial .
19470889	0	Apixaban	145,153	factor_Xa	37,46	Apixaban	factor Xa	MESH:C522181	2159	Chemical	Gene	results|nmod|START_ENTITY Apixaban|dep|results Apixaban|appos|inhibitor inhibitor|compound|END_ENTITY	Apixaban , an oral , direct , selective factor_Xa inhibitor , in combination with antiplatelet therapy after acute_coronary_syndrome : results of the Apixaban for Prevention of Acute Ischemic and Safety Events -LRB- APPRAISE -RRB- trial .
19921101	0	Apixaban	0,8	factor_Xa	27,36	Apixaban	factor Xa	MESH:C522181	2159	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Apixaban : an emerging oral factor_Xa inhibitor .
20589316	0	Apixaban	0,8	factor_Xa	19,28	Apixaban	factor Xa	MESH:C522181	2159	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Apixaban , a direct factor_Xa inhibitor , inhibits tissue-factor induced human platelet_aggregation in vitro : comparison with direct inhibitors of factor VIIa , XIa and thrombin .
21171894	0	Apixaban	0,8	factor_Xa	23,32	Apixaban	factor Xa	MESH:C522181	2159	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	Apixaban inhibition of factor_Xa : Microscopic rate constants and inhibition mechanism in purified protein systems and in human plasma .
22722590	0	Apixaban	0,8	factor_Xa	36,45	Apixaban	factor Xa	MESH:C522181	2159	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	Apixaban : a novel oral inhibitor of factor_Xa .
22759198	0	Apixaban	0,8	factor_Xa	26,35	Apixaban	factor Xa	MESH:C522181	2159	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Apixaban , an oral , direct factor_Xa inhibitor : single dose safety , pharmacokinetics , pharmacodynamics and food effect in healthy subjects .
23535530	0	Apixaban	0,8	factor_Xa	16,25	Apixaban	factor Xa	MESH:C522181	2159	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Apixaban : a new factor_Xa inhibitor for stroke prevention in patients with nonvalvular atrial_fibrillation .
24554904	0	Apixaban	29,37	factor_Xa	8,17	Apixaban	factor Xa	MESH:C522181	2159	Chemical	Gene	inhibitor|dep|START_ENTITY inhibitor|compound|END_ENTITY	The new factor_Xa inhibitor : Apixaban .
12529660	0	Aplidine	0,8	vascular_endothelial_growth_factor	60,94	Aplidine	vascular endothelial growth factor	MESH:C098980	7422	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|amod|END_ENTITY	Aplidine , a new anticancer agent of marine origin , inhibits vascular_endothelial_growth_factor -LRB- VEGF -RRB- secretion and blocks VEGF-VEGFR-1 -LRB- flt-1 -RRB- autocrine loop in human leukemia cells MOLT-4 .
26780950	7	Apocynin	1737,1745	p47phox	1771,1778	Apocynin	p47phox	MESH:C056165	17969(Tax:10090)	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	Apocynin or genetic inhibition of p47phox significantly protected these signaling processes induced by MA .
18275607	0	Apogossypolone	23,37	Bcl-2	89,94	Apogossypolone	Bcl-2	MESH:C534401	596	Chemical	Gene	studies|nmod|START_ENTITY studies|dep|inhibitor inhibitor|nmod|proteins proteins|compound|END_ENTITY	Preclinical studies of Apogossypolone : a new nonpeptidic pan small-molecule inhibitor of Bcl-2 , Bcl-XL and Mcl-1 proteins in Follicular Small Cleaved Cell Lymphoma model .
18769131	0	Apogossypolone	0,14	Bcl-2	65,70	Apogossypolone	Bcl-2	MESH:C534401	596	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|acl|targeting targeting|dobj|proteins proteins|compound|END_ENTITY	Apogossypolone , a nonpeptidic small molecule inhibitor targeting Bcl-2 family proteins , effectively inhibits growth of diffuse_large_cell_lymphoma cells in vitro and in vivo .
21033669	3	Apogossypolone	482,496	Bcl-2	581,586	Apogossypolone	Mcl-1	MESH:C534401	17210(Tax:10090)	Chemical	Gene	6a|appos|START_ENTITY series|nmod|6a resonance|appos|series Guided|nmod|resonance derivatives|amod|Guided synthesized|nsubjpass|derivatives synthesized|nmod|proteins proteins|compound|END_ENTITY	Guided by nuclear magnetic resonance -LRB- NMR -RRB- binding assays , a series of 5,5 ' substituted compound 6a -LRB- Apogossypolone -RRB- derivatives was synthesized and identified pan-active antagonists of antiapoptotic Bcl-2 family proteins , with binding potency in the low micromolar to nanomolar range .
24919770	0	Apogossypolone	0,14	Bcl-2	46,51	Apogossypolone	Bcl-2	MESH:C534401	12043(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Apogossypolone , a small-molecule inhibitor of Bcl-2 , induces radiosensitization of nasopharyngeal_carcinoma cells by stimulating autophagy .
17230522	0	Apomine	0,7	HMG-CoA-reductase	25,42	Apomine	HMG-CoA-reductase	MESH:C407151	3156	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Apomine , an inhibitor of HMG-CoA-reductase , promotes apoptosis of myeloma cells in vitro and is associated with a modulation of myeloma in vivo .
26458144	0	Apoptozole	14,24	HSP70	49,54	Apoptozole	HSP70	null	3308	Chemical	Gene	START_ENTITY|nmod|Inhibition Inhibition|compound|END_ENTITY	Investigating Apoptozole as a Chemical Probe for HSP70 Inhibition .
23890777	0	Apotransferrin	0,14	interleukin-2	24,37	Apotransferrin	interleukin-2	CHEBI:2786	16183(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Apotransferrin inhibits interleukin-2 expression and protects mice from experimental_autoimmune_encephalomyelitis .
25904310	0	Appetite	14,22	Vasoactive_Intestinal_Polypeptide	68,101	Appetite	Vasoactive Intestinal Polypeptide	null	22353(Tax:10090)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of Appetite , Body Composition , and Metabolic Hormones by Vasoactive_Intestinal_Polypeptide -LRB- VIP -RRB- .
26536384	0	Apremilast	97,107	PDE4	81,85	Apremilast	PDE4	MESH:C505730	5141	Chemical	Gene	Phosphodiesterase_4|dobj|START_ENTITY Phosphodiesterase_4|dep|END_ENTITY	Treatment of Refractory Pityriasis Rubra_Pilaris With Novel Phosphodiesterase_4 -LRB- PDE4 -RRB- Inhibitor Apremilast .
19844858	0	Apricoxib	0,9	COX-2	13,18	Apricoxib	COX-2	MESH:C514354	4513	Chemical	Gene	inhibitor|advmod|START_ENTITY inhibitor|nsubj|END_ENTITY	Apricoxib , a COX-2 inhibitor for the potential treatment of pain and cancer .
22829202	0	Apricoxib	0,9	COX-2	32,37	Apricoxib	COX-2	MESH:C514354	4513	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Apricoxib , a novel inhibitor of COX-2 , markedly improves standard therapy response in molecularly defined models of pancreatic_cancer .
7605876	0	Aprosulate	19,29	tissue_factor_pathway_inhibitor	63,94	Aprosulate	tissue factor pathway inhibitor	MESH:C069690	7035	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Effect of repeated Aprosulate and Enoxaparin administration on tissue_factor_pathway_inhibitor antigen levels .
11420167	0	Aprotinin	0,9	IL-8	22,26	Aprotinin	IL-8	null	3576	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	Aprotinin reduces the IL-8 after coronary artery bypass grafting .
9876093	0	Aprotinin	0,9	p-selectin	36,46	Aprotinin	p-selectin	null	6403	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|nmod|END_ENTITY	Aprotinin reduces the expression of p-selectin on the surface of platelet and leukocyte-platelet conjugates .
9308747	0	Aprotinin	0,9	plasmin	82,89	Aprotinin	plasmin	null	5340	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|nmod|inhibition inhibition|nmod|END_ENTITY	Aprotinin reduces blood_loss after cardiopulmonary bypass by direct inhibition of plasmin .
16399290	0	Aprotinin	0,9	protease-activated_receptor_1	91,120	Aprotinin	protease-activated receptor 1	null	2149	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Aprotinin inhibits proinflammatory activation of endothelial cells by thrombin through the protease-activated_receptor_1 .
10395480	0	Apstatin	0,8	aminopeptidase_P	32,48	Apstatin	aminopeptidase P	MESH:C097277	351	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Apstatin analogue inhibitors of aminopeptidase_P , a bradykinin-degrading enzyme .
11564655	0	Apstatin	0,8	aminopeptidase_P	35,51	Apstatin	aminopeptidase P	MESH:C097277	54226(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Apstatin , a selective inhibitor of aminopeptidase_P , reduces myocardial_infarct size by a kinin-dependent pathway .
22550388	0	Aquaporins	128,138	aquaporin_5	22,33	Aquaporins	aquaporin 5	null	362	Chemical	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Spatial expression of aquaporin_5 in mammalian cornea and lens , and regulation of its localization by phosphokinase A. PURPOSE : Aquaporins -LRB- AQPs -RRB- play a significant role in the movement of water across the plasma membrane .
14586480	0	Ara-C	56,61	CD34	11,15	Ara-C	CD34	MESH:D003561	947	Chemical	Gene	+|nmod|START_ENTITY +|nsubj|END_ENTITY	Successful CD34 + cell mobilization by intermediate-dose Ara-C in chronic_lymphocytic_leukemia patients treated with sequential fludarabine and Campath-1H .
14574327	0	Ara-C	67,72	breast_cancer_resistance_protein	100,132	Ara-C	breast cancer resistance protein	MESH:D003561	9429	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Multidrug resistance genes in infant acute_lymphoblastic_leukemia : Ara-C is not a substrate for the breast_cancer_resistance_protein .
3085651	0	Arachidonate	0,12	thrombin	112,120	Arachidonate	thrombin	CHEBI:32395	29251(Tax:10116)	Chemical	Gene	mobilization|amod|START_ENTITY phospholipids|nsubj|mobilization phospholipids|nmod|END_ENTITY	Arachidonate mobilization in diacyl , alkylacyl and alkenylacyl phospholipids on stimulation of rat platelets by thrombin and the Ca2 + ionophore A23187 .
26632190	0	Arachidonic_Acid	61,77	CYP2C8	82,88	Arachidonic Acid	CYP2C8	MESH:D016718	1558	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of Angiotensin II Receptor Blockers on Metabolism of Arachidonic_Acid via CYP2C8 .
12754389	0	Arachidonic_Acid	53,69	Phospholipase_A2	29,45	Arachidonic Acid	Phospholipase A2	MESH:D016718	151056	Chemical	Gene	Cascade|compound|START_ENTITY END_ENTITY|nmod|Cascade	In Vivo Effect of Pancreatic Phospholipase_A2 on the Arachidonic_Acid Cascade .
25691139	0	Arachidonic_Acid	98,114	Phospholipase_A2	81,97	Arachidonic Acid	Phospholipase A2	MESH:D016718	151056	Chemical	Gene	Pathway|compound|START_ENTITY Activity|parataxis|Pathway Activity|nmod|END_ENTITY	Anti-inflammatory Activity of Magnesium_Isoglycyrrhizinate Through Inhibition of Phospholipase_A2 / Arachidonic_Acid Pathway .
11844797	0	Arachidonic_acid	0,16	5-lipoxygenase	45,59	Arachidonic acid	5-lipoxygenase	MESH:D016718	240	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Arachidonic_acid promotes phosphorylation of 5-lipoxygenase at Ser-271 by MAPK-activated_protein_kinase_2 -LRB- MK2 -RRB- .
14572603	0	Arachidonic_acid	0,16	5-lipoxygenase	132,146	Arachidonic acid	5-lipoxygenase	MESH:D016718	11689(Tax:10090)	Chemical	Gene	inhibitors|amod|START_ENTITY modulate|nsubj|inhibitors modulate|dobj|stress stress|dep|roles roles|acl|END_ENTITY	Arachidonic_acid cascade inhibitors modulate phorbol_ester-induced oxidative stress in female ICR mouse skin : differential roles of 5-lipoxygenase and cyclooxygenase-2 in leukocyte infiltration and activation .
16275640	0	Arachidonic_acid	0,16	5-lipoxygenase	48,62	Arachidonic acid	5-lipoxygenase	MESH:D016718	240	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|translocation translocation|nmod|END_ENTITY	Arachidonic_acid regulates the translocation of 5-lipoxygenase to the nuclear membranes in human neutrophils .
3008733	0	Arachidonic_acid	0,16	5-lipoxygenase	26,40	Arachidonic acid	5-lipoxygenase	MESH:D016718	240	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Arachidonic_acid inhibits 5-lipoxygenase in human T cells .
7599181	0	Arachidonic_acid	0,16	5-lipoxygenase	63,77	Arachidonic acid	5-lipoxygenase	MESH:D016718	240	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|dep|expression expression|amod|END_ENTITY	Arachidonic_acid metabolism in the human mast cell line HMC-1 : 5-lipoxygenase gene expression and biosynthesis of thromboxane .
9199209	0	Arachidonic_acid	0,16	5-lipoxygenase	74,88	Arachidonic acid	5-lipoxygenase	MESH:D016718	240	Chemical	Gene	stimulates|amod|START_ENTITY stimulates|dep|role role|nmod|END_ENTITY	Arachidonic_acid stimulates prostate_cancer cell growth : critical role of 5-lipoxygenase .
9649570	1	Arachidonic_acid	54,70	5-lipoxygenase	101,115	Arachidonic acid	5-lipoxygenase	MESH:D016718	240	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|Raf-1 Raf-1|dep|Mek/Erk Mek/Erk|nmod|END_ENTITY	Arachidonic_acid activates Raf-1 / Mek/Erk via a 5-lipoxygenase - dependent pathway .
12957656	0	Arachidonic_acid	0,16	AP-1	40,44	Arachidonic acid	AP-1	MESH:D016718	3725	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Arachidonic_acid activates a functional AP-1 and an inactive NF-kappaB complex in human HepG2 hepatoma cells .
8276864	0	Arachidonic_acid	0,16	GLUT4	80,85	Arachidonic acid	GLUT4	MESH:D016718	6517	Chemical	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|gene gene|appos|END_ENTITY	Arachidonic_acid down-regulates the insulin-dependent glucose_transporter gene -LRB- GLUT4 -RRB- in 3T3-L1 adipocytes by inhibiting transcription and enhancing mRNA turnover .
11844797	0	Arachidonic_acid	0,16	MAPK-activated_protein_kinase_2	74,105	Arachidonic acid	MAPK-activated protein kinase 2	MESH:D016718	9261	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Arachidonic_acid promotes phosphorylation of 5-lipoxygenase at Ser-271 by MAPK-activated_protein_kinase_2 -LRB- MK2 -RRB- .
9649570	1	Arachidonic_acid	54,70	Raf-1	81,86	Arachidonic acid	Raf-1	MESH:D016718	5894	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Arachidonic_acid activates Raf-1 / Mek/Erk via a 5-lipoxygenase - dependent pathway .
11997249	0	Arachidonic_acid	0,16	TNF-alpha	41,50	Arachidonic acid	TNF-alpha	MESH:D016718	24835(Tax:10116)	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|dobj|effect effect|nmod|END_ENTITY	Arachidonic_acid mediates dual effect of TNF-alpha on Ca2 + transients and contraction of adult rat cardiomyocytes .
19339510	0	Arachidonic_acid	0,16	VEGF	45,49	Arachidonic acid	VEGF	MESH:D016718	22339(Tax:10090)	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|expression expression|amod|END_ENTITY	Arachidonic_acid potentiates hypoxia-induced VEGF expression in mouse embryonic stem cells : involvement of Notch , Wnt , and HIF-1alpha .
24879802	0	Arachidonic_acid	0,16	acyl-CoA_synthetase_4	31,52	Arachidonic acid	acyl-CoA synthetase 4	MESH:D016718	2182	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	Arachidonic_acid downregulates acyl-CoA_synthetase_4 expression by promoting its ubiquitination and proteasomal degradation .
9575888	0	Arachidonic_acid	0,16	angiotensin_II	81,95	Arachidonic acid	angiotensin II	MESH:D016718	183	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|nmod|END_ENTITY	Arachidonic_acid potentiates the feedback response of mesangial BKCa channels to angiotensin_II .
9636164	0	Arachidonic_acid	0,16	angiotensin_II	26,40	Arachidonic acid	angiotensin II	MESH:D016718	183	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|dobj|effects effects|amod|END_ENTITY	Arachidonic_acid mediates angiotensin_II effects on p21ras in renal proximal tubular cells via the tyrosine kinase-Shc-Grb2-Sos pathway .
7789516	0	Arachidonic_acid	0,16	apolipoprotein_D	26,42	Arachidonic acid	apolipoprotein D	MESH:D016718	347	Chemical	Gene	binds|amod|START_ENTITY binds|nmod|END_ENTITY	Arachidonic_acid binds to apolipoprotein_D : implications for the protein 's function .
4283109	0	Arachidonic_acid	1,17	bradykinin	29,39	Arachidonic acid	bradykinin	MESH:D016718	3827	Chemical	Gene	release|nsubj|START_ENTITY release|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Arachidonic_acid release by bradykinin -RSB- .
8385778	0	Arachidonic_acid	0,16	bradykinin	70,80	Arachidonic acid	bradykinin	MESH:D016718	3827	Chemical	Gene	release|nsubj|START_ENTITY release|nmod|peptides peptides|compound|END_ENTITY	Arachidonic_acid release and inositol lipid metabolism in response to bradykinin and related peptides in human endometrial cells in vitro .
2840568	0	Arachidonic_acid	0,16	c-fos	67,72	Arachidonic acid	c-fos	MESH:D016718	14281(Tax:10090)	Chemical	Gene	stimulation|amod|START_ENTITY stimulation|nmod|expression expression|amod|END_ENTITY	Arachidonic_acid and cyclic_adenosine_monophosphate stimulation of c-fos expression by a pathway independent of phorbol_ester-sensitive protein kinase C .
7961634	0	Arachidonic_acid	0,16	c-fos	27,32	Arachidonic acid	c-fos	MESH:D016718	14281(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|mRNA mRNA|amod|END_ENTITY	Arachidonic_acid increases c-fos and Egr-1 mRNA in 3T3 fibroblasts by formation of prostaglandin_E2 and activation of protein kinase C. Studying Swiss_3T3 fibroblasts , we report that arachidonic_acid strongly stimulates mRNA levels of the growth-associated immediate early genes c-fos and Egr-1 .
9357993	0	Arachidonic_acid	0,16	c-fos	84,89	Arachidonic acid	c-fos	MESH:D016718	2353	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|element element|amod|END_ENTITY	Arachidonic_acid , a principal product of Rac-activated phospholipase_A2 , stimulates c-fos serum response element via Rho-dependent mechanism .
10359021	0	Arachidonic_acid	0,16	c-jun	146,151	Arachidonic acid	c-jun	MESH:D016718	16476(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|mobilization mobilization|dep|evidence evidence|dep|associated associated|nmod|activation activation|amod|END_ENTITY	Arachidonic_acid induces mobilization of calcium stores and c-jun gene expression : evidence that intracellular calcium release is associated with c-jun activation .
7579389	0	Arachidonic_acid	0,16	c-jun	25,30	Arachidonic acid	c-jun	MESH:D016718	16476(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Arachidonic_acid induces c-jun gene expression in stromal cells stimulated by interleukin-1 and tumor_necrosis_factor-alpha : evidence for a tyrosine-kinase-dependent process .
12064462	0	Arachidonic_acid	0,16	cPLA2	28,33	Arachidonic acid	cPLA2	MESH:D016718	24653(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	Arachidonic_acid release by cPLA2 may be causally related to NO-induced apoptosis in vascular smooth muscle cells .
7542448	0	Arachidonic_acid	0,16	cytosolic_phospholipase_A2	68,94	Arachidonic acid	cytosolic phospholipase A2	MESH:D016718	5321	Chemical	Gene	mobilization|amod|START_ENTITY suppressed|nsubjpass|mobilization suppressed|nmod|mitosis mitosis|dep|role role|nmod|activation activation|amod|END_ENTITY	Arachidonic_acid mobilization is suppressed during mitosis : role of cytosolic_phospholipase_A2 activation .
10572254	0	Arachidonic_acid	0,16	endothelin-1	25,37	Arachidonic acid	endothelin-1	MESH:D016718	281137(Tax:9913)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Arachidonic_acid induces endothelin-1 gene expression in vascular endothelial cells .
14561212	0	Arachidonic_acid	0,16	insulin	108,115	Arachidonic acid	insulin	MESH:D016718	3630	Chemical	Gene	START_ENTITY|nsubjpass|secretion secretion|compound|END_ENTITY	Arachidonic_acid , palmitic_acid and glucose are important for the modulation of clonal pancreatic beta-cell insulin secretion , growth and functional integrity .
17204958	0	Arachidonic_acid	0,16	insulin	62,69	Arachidonic acid	insulin	MESH:D016718	3630	Chemical	Gene	content|amod|START_ENTITY associated|nsubjpass|content associated|nmod|resistance resistance|compound|END_ENTITY	Arachidonic_acid content in adipose tissue is associated with insulin resistance in healthy children .
7511246	0	Arachidonic_acid	0,16	interleukin-6	28,41	Arachidonic acid	interleukin-6	MESH:D016718	24498(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|amod|END_ENTITY	Arachidonic_acid stimulates interleukin-6 release from rat peritoneal macrophages in vitro : evidence for a prostacyclin-dependent mechanism .
19331685	0	Arachidonic_acid	0,16	matrix_metalloproteinase_9	27,53	Arachidonic acid	matrix metalloproteinase 9	MESH:D016718	4318	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|secretion secretion|amod|END_ENTITY	Arachidonic_acid increases matrix_metalloproteinase_9 secretion and expression in human monocytic MonoMac 6 cells .
6408933	0	Arachidonic_acid	0,16	mucin	28,33	Arachidonic acid	mucin	MESH:D016718	442975(Tax:9615)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|compound|END_ENTITY	Arachidonic_acid stimulates mucin secretion in prairie dog gallbladder .
9383037	0	Arachidonic_acid	0,16	myelin_basic_protein	26,46	Arachidonic acid	myelin basic protein	MESH:D016718	24547(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Arachidonic_acid inhibits myelin_basic_protein phosphorylation in cultured oligodendrocytes .
9636164	0	Arachidonic_acid	0,16	p21ras	52,58	Arachidonic acid	p21ras	MESH:D016718	3265	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Arachidonic_acid mediates angiotensin_II effects on p21ras in renal proximal tubular cells via the tyrosine kinase-Shc-Grb2-Sos pathway .
16210322	0	Arachidonic_acid	0,16	p38	89,92	Arachidonic acid	p38	MESH:D016718	1432	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|induction induction|nmod|glucose-6-phosphate_dehydrogenase glucose-6-phosphate_dehydrogenase|nmod|kinase kinase|amod|END_ENTITY	Arachidonic_acid inhibits the insulin induction of glucose-6-phosphate_dehydrogenase via p38 MAP kinase .
19506078	0	Arachidonic_acid	0,16	p38	58,61	Arachidonic acid	p38	MESH:D016718	1432	Chemical	Gene	START_ENTITY|nsubj|MAPK-RhoA MAPK-RhoA|compound|END_ENTITY	Arachidonic_acid stimulates cell adhesion through a novel p38 MAPK-RhoA signaling pathway that involves heat_shock protein 27 .
19720122	0	Arachidonic_acid	0,16	p38	153,156	Arachidonic acid	p38	MESH:D016718	1432	Chemical	Gene	Fas|compound|START_ENTITY Fas|dep|suppression suppression|nmod|pathway pathway|nmod|pathway pathway|amod|END_ENTITY	Arachidonic_acid induces Fas and FasL upregulation in human leukemia U937 cells via Ca2 + / ROS-mediated suppression of ERK/c-Fos pathway and activation of p38 MAPK/ATF -2 pathway .
15878913	0	Arachidonic_acid	0,16	phospholipase_A2	61,77	Arachidonic acid	phospholipase A2	MESH:D016718	151056	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Arachidonic_acid , an omega-6_fatty_acid , induces cytoplasmic phospholipase_A2 in prostate_carcinoma cells .
9357993	0	Arachidonic_acid	0,16	phospholipase_A2	55,71	Arachidonic acid	phospholipase A2	MESH:D016718	151056	Chemical	Gene	START_ENTITY|appos|product product|nmod|END_ENTITY	Arachidonic_acid , a principal product of Rac-activated phospholipase_A2 , stimulates c-fos serum response element via Rho-dependent mechanism .
8195210	0	Arachidonyl_trifluoromethyl_ketone	0,34	phospholipase_A2	65,81	Arachidonyl trifluoromethyl ketone	phospholipase A2	MESH:C081565	151056	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Arachidonyl_trifluoromethyl_ketone , a potent inhibitor of 85-kDa phospholipase_A2 , blocks production of arachidonate and 12-hydroxyeicosatetraenoic_acid by calcium ionophore-challenged platelets .
12921861	0	Arachidonylcyclopropylamide	0,27	CB2	84,87	Arachidonylcyclopropylamide	CB2	MESH:C119324	12802(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|nmod|END_ENTITY	Arachidonylcyclopropylamide increases microglial cell migration through cannabinoid CB2 and abnormal-cannabidiol-sensitive receptors .
8695657	0	Arbutin	0,7	PLA2	17,21	Arbutin	PLA2	MESH:D001104	151056	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Arbutin inhibits PLA2 in partially hydrated model systems .
23781272	0	Arctigenin	21,31	Tyrosinase	99,109	Arctigenin	Tyrosinase	MESH:C071942	22173(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|Expression Expression|compound|END_ENTITY	Inhibitory Effect of Arctigenin from Fructus Arctii Extract on Melanin Synthesis via Repression of Tyrosinase Expression .
21426947	0	Arctigenin	0,10	iNOS	47,51	Arctigenin	iNOS	MESH:C071942	18126(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Arctigenin inhibits lipopolysaccharide-induced iNOS expression in RAW264 .7 cells through suppressing JAK-STAT signal pathway .
21435270	0	Arctigenin	0,10	interleukin-2	39,52	Arctigenin	interleukin-2	MESH:C071942	3558	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Arctigenin from Arctium lappa inhibits interleukin-2 and interferon gene expression in primary human T lymphocytes .
25968940	0	Arctigenin	0,10	monocyte_chemoattractant_protein-1	74,108	Arctigenin	monocyte chemoattractant protein-1	MESH:C071942	6347	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|nmod|END_ENTITY	Arctigenin suppresses transforming_growth_factor-b1-induced expression of monocyte_chemoattractant_protein-1 and the subsequent epithelial-mesenchymal_transition through reactive oxygen species-dependent ERK/NF-kB signaling pathway in renal tubular epithelial cells .
21317023	0	Arecoline	0,9	Cyr61	21,26	Arecoline	Cyr61	MESH:D001115	3491	Chemical	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	Arecoline stimulated Cyr61 production in human gingival epithelial cells : inhibition by lovastatin .
17234337	0	Arecoline	0,9	cytochrome_P450_1A1	67,86	Arecoline	cytochrome P450 1A1	MESH:D001115	1543	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	Arecoline inhibits the 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced cytochrome_P450_1A1 activation in human hepatoma cells .
24304567	0	Arecoline	0,9	interleukin-2	19,32	Arecoline	interleukin-2	MESH:D001115	3558	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|compound|END_ENTITY	Arecoline inhibits interleukin-2 secretion in Jurkat cells by decreasing the expression of alpha7-nicotinic acetylcholine receptors and prostaglandin_E2 .
22108589	0	Arecoline	0,9	interleukin-6	20,33	Arecoline	interleukin-6	MESH:D001115	3569	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|production production|amod|END_ENTITY	Arecoline decreases interleukin-6 production and induces apoptosis and cell cycle arrest in human basal_cell_carcinoma cells .
18668345	0	Arecoline	0,9	mTOR	83,87	Arecoline	mTOR	MESH:D001115	21977(Tax:10090)	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	Arecoline and the 30-100 kDa fraction of areca nut extract differentially regulate mTOR and respectively induce apoptosis and autophagy : a pilot study .
18585839	0	Arecoline	0,9	p53	51,54	Arecoline	p53	MESH:D001115	7157	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Arecoline , a major alkaloid of areca nut , inhibits p53 , represses DNA repair , and triggers DNA damage response in human epithelial cells .
19117399	0	Arenamides_A-C	0,14	NFkappaB	26,34	Arenamides A-C	NFkappaB	null	4790	Chemical	Gene	START_ENTITY|appos|inhibitors inhibitors|compound|END_ENTITY	Arenamides_A-C , cytotoxic NFkappaB inhibitors from the marine actinomycete Salinispora_arenicola .
25858298	0	Arg	60,63	A13	49,52	Arg	A13	CHEBI:16467	28888	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|appos|END_ENTITY	Fortuitous description of haemoglobin A2 ' -LSB- 16 -LRB- A13 -RRB- Gly _ > _ Arg -LRB- GGC _ > _ CGC -RRB- -RSB- in a Tunisian family : study of the molecular defect and its origin .
20075158	0	Arg	20,23	ADAMTS13	77,85	Arg	ADAMTS13	CHEBI:16467	11093	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Amino_acid residues Arg -LRB- 659 -RRB- , Arg -LRB- 660 -RRB- , and Tyr -LRB- 661 -RRB- in the spacer domain of ADAMTS13 are critical for cleavage of von_Willebrand factor .
25043977	4	Arg	727,730	INSL5	769,774	Arg	INSL5	CHEBI:16467	10022	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	Second , we demonstrated that two positively charged B-chain Arg residues -LRB- B13Arg and B23Arg -RRB- in human INSL5 were involved in receptor binding and activation .
10430617	0	Arg	13,16	IRS-1	44,49	Arg	IRS-1	CHEBI:16467	3667	Chemical	Gene	polymorphism|compound|START_ENTITY polymorphism|nmod|secretion secretion|compound|END_ENTITY	The Gly972 -- > Arg amino acid polymorphism in IRS-1 impairs insulin secretion in pancreatic beta cells .
11978638	0	Arg	88,91	IRS-1	92,97	Arg	IRS-1	CHEBI:16467	3667	Chemical	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	Insulin secretory function is impaired in isolated human islets carrying the Gly -LRB- 972 -RRB- -- > Arg IRS-1 polymorphism .
12606535	0	Arg	13,16	IRS-1	17,22	Arg	IRS-1	CHEBI:16467	3667	Chemical	Gene	variant|compound|START_ENTITY variant|compound|END_ENTITY	The Gly972 -- > Arg IRS-1 variant is associated with type 1 diabetes in continental Italy .
1569192	0	Arg	11,14	alpha_1-antitrypsin	27,46	Arg	alpha 1-antitrypsin	CHEBI:16467	5265	Chemical	Gene	mutation|compound|START_ENTITY mutation|nmod|END_ENTITY	Met 358 to Arg mutation of alpha_1-antitrypsin associated with protein_C_deficiency in a patient with mild bleeding tendency .
19414610	0	Arg	0,3	cortactin	19,28	Arg	cortactin	CHEBI:16467	2017	Chemical	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Arg interacts with cortactin to promote adhesion-dependent cell edge protrusion .
14653737	0	Arg	25,28	cyclophilin_A	52,65	Arg	cyclophilin A	CHEBI:16467	5478	Chemical	Gene	START_ENTITY|nmod|catalysis catalysis|nmod|END_ENTITY	What is so special about Arg 55 in the catalysis of cyclophilin_A ?
11884718	0	Arg-Gly-Asp	91,102	integrin_alpha_Vbeta3	50,71	Arg-Gly-Asp	integrin alpha Vbeta3	MESH:C047981	3685	Chemical	Gene	complex|nmod|START_ENTITY END_ENTITY|nmod|complex	Crystal structure of the extracellular segment of integrin_alpha_Vbeta3 in complex with an Arg-Gly-Asp ligand .
2318314	0	Arg-Gly-Asp	22,33	laminin_A_chain	46,61	Arg-Gly-Asp	laminin A chain	MESH:C047981	284217	Chemical	Gene	sequence|compound|START_ENTITY sequence|nmod|END_ENTITY	Identification of the Arg-Gly-Asp sequence in laminin_A_chain as a latent cell-binding site being exposed in fragment P1 .
1988465	0	Arg-Gly-Asp	3,14	thrombin	31,39	Arg-Gly-Asp	thrombin	MESH:C047981	2147	Chemical	Gene	sequence|compound|START_ENTITY sequence|nmod|END_ENTITY	An Arg-Gly-Asp sequence within thrombin promotes endothelial cell adhesion .
10923408	0	Arg-Gly-Asp-Ser	12,27	RGDS	29,33	Arg-Gly-Asp-Ser	RGDS	MESH:C046617	5900	Chemical	Gene	tetrapeptide|amod|START_ENTITY tetrapeptide|appos|END_ENTITY	-LSB- Effects of Arg-Gly-Asp-Ser -LRB- RGDS -RRB- tetrapeptide on apoptosis-related genes in glomerular mesangial cells -RSB- .
11324534	0	Arg-Gly-Asp-Ser	11,26	RGDS	28,32	Arg-Gly-Asp-Ser	RGDS	MESH:C046617	29622(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	-LSB- Effect of Arg-Gly-Asp-Ser -LRB- RGDS -RRB- peptide on ADP-induced signal transduction of activated rat platelet -RSB- .
12824296	0	Arg-Gly-Asp-Ser	0,15	RGDS	17,21	Arg-Gly-Asp-Ser	RGDS	MESH:C046617	5900	Chemical	Gene	stimulates|amod|START_ENTITY stimulates|appos|END_ENTITY	Arg-Gly-Asp-Ser -LRB- RGDS -RRB- peptide stimulates transforming growth factor beta1 transcription and secretion through integrin activation .
1737795	0	Arg-Gly-Asp-Ser	30,45	RGDS	47,51	Arg-Gly-Asp-Ser	RGDS	MESH:C046617	5900	Chemical	Gene	site|amod|START_ENTITY site|appos|END_ENTITY	Selective inactivation of the Arg-Gly-Asp-Ser -LRB- RGDS -RRB- binding site in von_Willebrand factor by site-directed mutagenesis .
8222396	0	Arg-Gly-Asp-Ser	34,49	RGDS	51,55	Arg-Gly-Asp-Ser	RGDS	MESH:C046617	19730(Tax:10090)	Chemical	Gene	peptide|amod|START_ENTITY peptide|appos|END_ENTITY	Inhibition of tumor metastasis by Arg-Gly-Asp-Ser -LRB- RGDS -RRB- peptide conjugated with sulfated chitin derivative , SCM-chitin-RGDS .
25288495	0	Arg-Phe-NH2	19,30	MrgC	81,85	Arg-Phe-NH2	MrgC	MESH:C058047	404646(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Peptidomimetics of Arg-Phe-NH2 as small molecule agonists of Mas-related gene C -LRB- MrgC -RRB- receptors .
1479739	0	Arg-Pro-Pro-Gly-Phe	21,40	bradykinin	45,55	Arg-Pro-Pro-Gly-Phe	bradykinin	MESH:C079000	3827	Chemical	Gene	metabolite|appos|START_ENTITY metabolite|nmod|END_ENTITY	A stable metabolite , Arg-Pro-Pro-Gly-Phe , of bradykinin in the degradation pathway in human plasma .
20129829	4	Arg492Cys	703,712	ADRA1A	714,720	Arg492Cys	SLC6A4	null	6532	Chemical	Gene	START_ENTITY|appos|gene gene|compound|END_ENTITY	The analysed polymorphisms were Arg492Cys -LRB- ADRA1A gene -RRB- , Ser49Gly and Arg389Gly -LRB- ADRB1 -RRB- , Arg16Gly and Gln27Glu -LRB- ADRB2 -RRB- , 825C/T -LRB- GNB3 -RRB- , -1021 C/T -LRB- DBH -RRB- and S/L -LRB- SLC6A4 -RRB- .
10674629	0	Argatroban	0,10	thrombin	14,22	Argatroban	thrombin	MESH:C031942	2147	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Argatroban , a thrombin inhibitor , decreased mortality after 10 min of forebrain_ischemia in the gerbil .
11975790	0	Argatroban	0,10	thrombin	21,29	Argatroban	thrombin	MESH:C031942	2147	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Argatroban : a direct thrombin inhibitor for heparin-induced_thrombocytopenia and other clinical applications .
12568910	0	Argatroban	0,10	thrombin	21,29	Argatroban	thrombin	MESH:C031942	100009146(Tax:9986)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Argatroban , specific thrombin inhibitor , induced phenotype change of cultured rabbit vascular smooth muscle cells .
16370925	0	Argatroban	0,10	thrombin	21,29	Argatroban	thrombin	MESH:C031942	2147	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Argatroban , a direct thrombin inhibitor for heparin-induced thrombocytopaenia : present and future perspectives .
16703119	0	Argatroban	0,10	thrombin	21,29	Argatroban	thrombin	MESH:C031942	2147	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Argatroban : a direct thrombin inhibitor with reliable and predictable anticoagulant actions .
8889361	0	Argatroban	0,10	thrombin	24,32	Argatroban	thrombin	MESH:C031942	2147	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Argatroban : a synthetic thrombin inhibitor of low relative molecular mass .
8937032	0	Argatroban	1,11	thrombin	25,33	Argatroban	thrombin	MESH:C031942	2147	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	-LSB- Argatroban , a selective thrombin inhibitor , for anticoagulant therapy during and following vascular surgery -RSB- .
22095282	0	Arginine	0,8	ASK1	45,49	Arginine	ASK1	CHEBI:29016	4217	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Arginine methylation-dependent regulation of ASK1 signaling by PRMT1 .
19926723	0	Arginine	0,8	Aubergine	24,33	Arginine	Aubergine	CHEBI:29016	34524(Tax:7227)	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	Arginine methylation of Aubergine mediates Tudor binding and germ plasm localization .
21444773	0	Arginine	0,8	BCL-2_antagonist_of_cell_death	24,54	Arginine	BCL-2 antagonist of cell death	CHEBI:29016	572	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	Arginine methylation of BCL-2_antagonist_of_cell_death -LRB- BAD -RRB- counteracts its phosphorylation and inactivation by Akt .
20231378	0	Arginine	0,8	B_cell_antigen_receptor	28,51	Arginine	B cell antigen receptor	CHEBI:29016	613	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	Arginine methylation of the B_cell_antigen_receptor promotes differentiation .
26003171	0	Arginine	34,42	CD36	12,16	Arginine	CD36	CHEBI:29016	29184(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Role|nmod|Effect Role|nmod|END_ENTITY	The Role of CD36 in the Effect of Arginine in Atherosclerotic Rats .
24570487	0	Arginine	0,8	CRTC2	24,29	Arginine	CRTC2	CHEBI:29016	74343(Tax:10090)	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	Arginine methylation of CRTC2 is critical in the transcriptional control of hepatic glucose metabolism .
21652632	0	Arginine	0,8	G3BP1	24,29	Arginine	G3BP1	CHEBI:29016	10146	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	Arginine methylation of G3BP1 in response to Wnt3a regulates b-catenin mRNA .
1592874	0	Arginine	0,8	GH	40,42	Arginine	GH	CHEBI:29016	2688	Chemical	Gene	normalizes|nsubj|START_ENTITY normalizes|dobj|response response|appos|END_ENTITY	Arginine normalizes the growth_hormone -LRB- GH -RRB- response to GH-releasing_hormone in adult patients receiving chronic daily immunosuppressive glucocorticoid therapy .
22641416	0	Arginine	0,8	GH	17,19	Arginine	GH	CHEBI:29016	81668(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Arginine induces GH gene expression by activating NOS/NO signaling in rat isolated hemi-pituitaries .
23843806	0	Arginine	10,18	Growth_Hormone	52,66	Arginine	Growth Hormone	CHEBI:29016	2688	Chemical	Gene	Infusion|compound|START_ENTITY Effect|nmod|Infusion Effect|nmod|Secretion Secretion|nmod|Sufficient Sufficient|compound|END_ENTITY	Effect of Arginine Infusion on Ghrelin Secretion in Growth_Hormone Sufficient and GH Deficient Children .
26080448	0	Arginine	0,8	HSP70	24,29	Arginine	HSP70	CHEBI:29016	3308	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	Arginine methylation of HSP70 regulates retinoid_acid-mediated RARb2 gene activation .
10024178	0	Arginine	0,8	Hrp1p	36,41	Arginine	Hrp1p	CHEBI:29016	853997(Tax:4932)	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	Arginine methylation and binding of Hrp1p to the efficiency element for mRNA 3 ' - end formation .
15741314	0	Arginine	0,8	MRE11	24,29	Arginine	MRE11	CHEBI:29016	4361	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	Arginine methylation of MRE11 by PRMT1 is required for DNA damage checkpoint control .
15327772	0	Arginine	0,8	NIP45	24,29	Arginine	NIP45	CHEBI:29016	18020(Tax:10090)	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	Arginine methylation of NIP45 modulates cytokine gene expression in effector T lymphocytes .
15998636	0	Arginine	0,8	Npl3	51,55	Arginine	Npl3	CHEBI:29016	852042(Tax:4932)	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	Arginine methylation of yeast mRNA-binding protein Npl3 directly affects its function , nuclear export , and intranuclear protein interactions .
15364944	0	Arginine	0,8	PRMT1	116,121	Arginine	PRMT1	CHEBI:29016	3276	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	Arginine methylation of scaffold_attachment_factor_A by heterogeneous_nuclear_ribonucleoprotein particle-associated PRMT1 .
21965298	0	Arginine	0,8	PRMT1	24,29	Arginine	PRMT1	CHEBI:29016	3276	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	Arginine methylation by PRMT1 regulates nuclear-cytoplasmic localization and toxicity of FUS/TLS harbouring ALS-linked mutations .
15654770	0	Arginine	0,8	PRMT5	102,107	Arginine	PRMT5	CHEBI:29016	10419	Chemical	Gene	methylation|amod|START_ENTITY regulates|nsubj|methylation regulates|dobj|expression expression|dep|role role|nmod|protein_arginine_methyltransferase_5 protein_arginine_methyltransferase_5|appos|END_ENTITY	Arginine methylation regulates IL-2 gene expression : a role for protein_arginine_methyltransferase_5 -LRB- PRMT5 -RRB- .
20956294	0	Arginine	0,8	PRMT5	60,65	Arginine	PRMT5	CHEBI:29016	829240(Tax:3702)	Chemical	Gene	methylation|amod|START_ENTITY methylation|acl|mediated mediated|nmod|homolog homolog|nmod|END_ENTITY	Arginine methylation mediated by the Arabidopsis homolog of PRMT5 is essential for proper pre-mRNA splicing .
21262773	0	Arginine	0,8	PRMT5	24,29	Arginine	PRMT5	CHEBI:29016	10419	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	Arginine methylation by PRMT5 at a naturally occurring mutation site is critical for liver metabolic regulation by small_heterodimer_partner .
25713080	0	Arginine	121,129	PRMT5	115,120	Arginine	PRMT5	CHEBI:29016	10419	Chemical	Gene	Methyltransferase|compound|START_ENTITY Methyltransferase|compound|END_ENTITY	Histone H2A and H4 N-Terminal Tails are Positioned by the MEP50 WD-Repeat Protein for Efficient Methylation by the PRMT5 Arginine Methyltransferase .
26035101	0	Arginine	56,64	PRMT5	113,118	Arginine	PRMT5	CHEBI:29016	10419	Chemical	Gene	Methylation|nmod|START_ENTITY Study|nmod|Methylation Catalyzed|nsubj|Study Catalyzed|nmod|END_ENTITY	Computational Study of Symmetric Methylation on Histone Arginine Catalyzed by Protein Arginine Methyltransferase PRMT5 through QM/MM MD and Free Energy Simulations .
26759235	0	Arginine	0,8	PRMT5	36,41	Arginine	PRMT5	CHEBI:29016	10419	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|SREBP1a SREBP1a|nmod|END_ENTITY	Arginine methylation of SREBP1a via PRMT5 promotes de novo lipogenesis and tumor growth .
16668789	0	Arginine	25,33	Phosphoribulokinase	66,85	Arginine	Phosphoribulokinase	CHEBI:29016	5719722(Tax:3055)	Chemical	Gene	Importance|nmod|START_ENTITY Importance|nmod|END_ENTITY	Functional Importance of Arginine 64 in Chlamydomonas_reinhardtii Phosphoribulokinase .
23624934	0	Arginine	0,8	RACO-1	46,52	Arginine	RACO-1	CHEBI:29016	149603	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	Arginine methylation of the c-Jun coactivator RACO-1 is required for c-Jun/AP -1 activation .
15084609	0	Arginine	0,8	RNA_helicase_a	24,38	Arginine	RNA helicase a	CHEBI:29016	1660	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	Arginine methylation of RNA_helicase_a determines its subcellular localization .
26759235	0	Arginine	0,8	SREBP1a	24,31	Arginine	SREBP1a	CHEBI:29016	6720	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	Arginine methylation of SREBP1a via PRMT5 promotes de novo lipogenesis and tumor growth .
11257227	0	Arginine	0,8	STAT1	24,29	Arginine	STAT1	CHEBI:29016	6772	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	Arginine methylation of STAT1 modulates IFNalpha/beta-induced transcription .
12171910	0	Arginine	0,8	STAT1	24,29	Arginine	STAT1	CHEBI:29016	6772	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	Arginine methylation of STAT1 regulates its dephosphorylation by T_cell_protein_tyrosine_phosphatase .
15550240	0	Arginine	0,8	STAT1	24,29	Arginine	STAT1	CHEBI:29016	6772	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	Arginine methylation of STAT1 : a reassessment .
20659974	0	Arginine	0,8	SmB	24,27	Arginine	SmB	CHEBI:29016	34426(Tax:7227)	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	Arginine methylation of SmB is required for Drosophila germ cell development .
3490852	0	Arginine	128,136	V1a	0,3	Arginine	V1a	CHEBI:29016	25107(Tax:10116)	Chemical	Gene	vasopressin|compound|START_ENTITY modulation|nmod|vasopressin myocytes|amod|modulation accumulation|dep|myocytes accumulation|amod|END_ENTITY	V1a vasopressin-induced accumulation of inositol_trisphosphate in cultured rat aortic myocytes ; modulation by protein kinase C. Arginine vasopressin stimulated the accumulation of labeled inositol_phosphate in cultured rat aortic myocytes prelabeled with tritiated myo-inositol .
26741910	0	Arginine	34,42	Vasopressin	43,54	Arginine	Vasopressin	CHEBI:29016	551	Chemical	Gene	Activity|compound|START_ENTITY Activity|compound|END_ENTITY	Regulation of CFTR Expression and Arginine Vasopressin Activity Are Dependent on Polycystin-1 in Kidney-Derived Cells .
1380442	0	Arginine	0,8	atrial_natriuretic_peptide	32,58	Arginine	atrial natriuretic peptide	CHEBI:29016	24602(Tax:10116)	Chemical	Gene	stimulates|amod|START_ENTITY END_ENTITY|nsubj|stimulates	Arginine vasopressin stimulates atrial_natriuretic_peptide gene expression and secretion from rat diencephalic neurons .
2122147	0	Arginine	0,8	carboxypeptidase_H	65,83	Arginine	carboxypeptidase H	CHEBI:29016	280753(Tax:9913)	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|amod|END_ENTITY	Arginine and lysine product inhibition of bovine adrenomedullary carboxypeptidase_H , a prohormone processing enzyme .
24726729	0	Arginine	0,8	cellular_nucleic_acid_binding_protein	28,65	Arginine	cellular nucleic acid binding protein	CHEBI:29016	7555	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	Arginine methylation of the cellular_nucleic_acid_binding_protein does not affect its subcellular localization but impedes RNA binding .
10595537	0	Arginine	0,8	cholecystokinin-A_receptor	20,46	Arginine	cholecystokinin-A receptor	CHEBI:29016	886	Chemical	Gene	START_ENTITY|nmod|site site|amod|END_ENTITY	Arginine 197 of the cholecystokinin-A_receptor binding site interacts with the sulfate of the peptide agonist cholecystokinin .
12590600	0	Arginine	0,8	cyclin_D1	35,44	Arginine	cyclin D1	CHEBI:29016	12443(Tax:10090)	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|expression expression|amod|END_ENTITY	Arginine vasopressin inhibition of cyclin_D1 gene expression blocks the cell cycle and cell proliferation in the mouse Y1 adrenocortical_tumor cell line .
10614542	0	Arginine	0,8	growth_hormone	42,56	Arginine	growth hormone	CHEBI:29016	2688	Chemical	Gene	changes|amod|START_ENTITY changes|nmod|levels levels|amod|END_ENTITY	Arginine infusion and/or acute changes of growth_hormone levels do not acutely alter leptin serum levels .
1355580	0	Arginine	0,8	growth_hormone	59,73	Arginine	growth hormone	CHEBI:29016	2688	Chemical	Gene	abolishes|nsubj|START_ENTITY abolishes|dobj|effect effect|nmod|glucose glucose|nmod|response response|amod|END_ENTITY	Arginine abolishes the inhibitory effect of glucose on the growth_hormone response to growth_hormone-releasing hormone in man .
14755131	0	Arginine	0,8	growth_hormone	19,33	Arginine	growth hormone	CHEBI:29016	81668(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Arginine increases growth_hormone gene expression in rat pituitary and GH3 cells .
1592874	0	Arginine	0,8	growth_hormone	24,38	Arginine	growth hormone	CHEBI:29016	2688	Chemical	Gene	normalizes|nsubj|START_ENTITY normalizes|dobj|response response|compound|END_ENTITY	Arginine normalizes the growth_hormone -LRB- GH -RRB- response to GH-releasing_hormone in adult patients receiving chronic daily immunosuppressive glucocorticoid therapy .
2903866	0	Arginine	0,8	growth_hormone	20,34	Arginine	growth hormone	CHEBI:29016	81668(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|amod|END_ENTITY	Arginine stimulates growth_hormone secretion by suppressing endogenous somatostatin secretion .
3115018	0	Arginine	0,8	growth_hormone	17,31	Arginine	growth hormone	CHEBI:29016	2688	Chemical	Gene	induced|compound|START_ENTITY END_ENTITY|nsubj|induced	Arginine induced growth_hormone -LRB- hGH -RRB- response and paradoxical hGH secretion stimulated by TRH in diabetes_mellitus .
8492725	0	Arginine	0,8	growth_hormone	71,85	Arginine	growth hormone	CHEBI:29016	2688	Chemical	Gene	blocks|nsubj|START_ENTITY blocks|advcl|circulating circulating|dobj|levels levels|amod|END_ENTITY	Arginine blocks the inhibitory effect of hydrocortisone on circulating growth_hormone levels in patients with acromegaly .
25104022	0	Arginine	0,8	hnRNPK	24,30	Arginine	hnRNPK	CHEBI:29016	3190	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	Arginine methylation of hnRNPK negatively modulates apoptosis upon DNA damage through local regulation of phosphorylation .
26020839	0	Arginine	0,8	hnRNPUL1	24,32	Arginine	hnRNPUL1	CHEBI:29016	11100	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	Arginine methylation of hnRNPUL1 regulates interaction with NBS1 and recruitment to sites of DNA damage .
26020839	0	Arginine	0,8	hnRNPUL1	24,32	Arginine	hnRNPUL1	CHEBI:29016	11100	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	Arginine methylation of hnRNPUL1 regulates interaction with NBS1 and recruitment to sites of DNA damage .
24098712	0	Arginine	0,8	hnRNP_A2	24,32	Arginine	hnRNP A2	CHEBI:29016	3181	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	Arginine methylation of hnRNP_A2 does not directly govern its subcellular localization .
18472002	0	Arginine	0,8	hnRNP_K	24,31	Arginine	hnRNP K	CHEBI:29016	3190	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	Arginine methylation of hnRNP_K enhances p53 transcriptional activity .
1330242	0	Arginine	0,8	insulin	17,24	Arginine	insulin	CHEBI:29016	3630	Chemical	Gene	induced|nsubj|START_ENTITY induced|dobj|release release|compound|END_ENTITY	Arginine induced insulin release in patients with newly onset non-insulin-dependent_diabetes_mellitus .
25611817	0	Arginine	0,8	insulin	27,34	Arginine	insulin	CHEBI:29016	3630	Chemical	Gene	dipeptides|amod|START_ENTITY affect|nsubj|dipeptides affect|dobj|aggregation aggregation|compound|END_ENTITY	Arginine dipeptides affect insulin aggregation in a pH - and ionic strength-dependent manner .
3539734	0	Arginine	0,8	insulin	60,67	Arginine	insulin	CHEBI:29016	100009181(Tax:9986)	Chemical	Gene	administrated|advmod|START_ENTITY administrated|nmod|stimulator stimulator|nmod|secretion secretion|compound|END_ENTITY	Arginine , administrated in various ways , as a stimulator of insulin secretion in the rabbit .
9701468	0	Arginine	0,8	insulin-like_growth_factor-I	19,47	Arginine	insulin-like growth factor-I	CHEBI:29016	3479	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|production production|amod|END_ENTITY	Arginine increases insulin-like_growth_factor-I production and collagen synthesis in osteoblast-like cells .
18156399	0	Arginine	0,8	p70	30,33	Arginine	p70	CHEBI:29016	309	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Arginine activates intestinal p70 -LRB- S6k -RRB- and protein synthesis in piglet_rotavirus_enteritis .
6394628	0	Arginine	0,8	prolactin	29,38	Arginine	prolactin	CHEBI:29016	280901(Tax:9913)	Chemical	Gene	infusion|amod|START_ENTITY stimulates|nsubj|infusion stimulates|dobj|END_ENTITY	Arginine infusion stimulates prolactin , growth hormone , insulin , and subsequent lactation in pregnant dairy cows .
19460357	0	Arginine	0,8	ribosomal_protein_S3	24,44	Arginine	ribosomal protein S3	CHEBI:29016	6188	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	Arginine methylation of ribosomal_protein_S3 affects ribosome assembly .
15364944	0	Arginine	0,8	scaffold_attachment_factor_A	24,52	Arginine	scaffold attachment factor A	CHEBI:29016	3192	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	Arginine methylation of scaffold_attachment_factor_A by heterogeneous_nuclear_ribonucleoprotein particle-associated PRMT1 .
2903866	0	Arginine	0,8	somatostatin	71,83	Arginine	somatostatin	CHEBI:29016	24797(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|advcl|suppressing suppressing|dobj|secretion secretion|compound|END_ENTITY	Arginine stimulates growth_hormone secretion by suppressing endogenous somatostatin secretion .
6148165	0	Arginine	0,8	somatostatin	46,58	Arginine	somatostatin	CHEBI:29016	6750	Chemical	Gene	infusion|amod|START_ENTITY increases|nsubj|infusion increases|dobj|END_ENTITY	Arginine infusion increases peripheral plasma somatostatin in man .
26381755	0	Arginine	0,8	ubiquitin-associated_protein_2-like	24,59	Arginine	ubiquitin-associated protein 2-like	CHEBI:29016	9898	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	Arginine methylation of ubiquitin-associated_protein_2-like is required for the accurate distribution of chromosomes .
10537286	0	Arginine	0,8	vasopressin	9,20	Arginine	vasopressin	CHEBI:29016	551	Chemical	Gene	regulation|amod|START_ENTITY regulation|compound|END_ENTITY	Arginine vasopressin promoter regulation is mediated by a neuron-restrictive silencer element in small_cell_lung_cancer .
10996978	0	Arginine	0,8	vasopressin	9,20	Arginine	vasopressin	CHEBI:29016	551	Chemical	Gene	secretion|amod|START_ENTITY secretion|compound|END_ENTITY	Arginine vasopressin secretion in Kenyan children with severe malaria .
12853804	0	Arginine	0,8	vasopressin	9,20	Arginine	vasopressin	CHEBI:29016	551	Chemical	Gene	START_ENTITY|dobj|polyuria polyuria|compound|END_ENTITY	Arginine vasopressin and nocturnal polyuria in older adults with frequent nighttime voiding .
12903775	0	Arginine	0,8	vasopressin	9,20	Arginine	vasopressin	CHEBI:29016	551	Chemical	Gene	START_ENTITY|dobj|expression expression|compound|END_ENTITY	Arginine vasopressin gene expression in supraoptic nucleus and paraventricular nucleus of hypothalamous following cerebral_ischemia and reperfusion .
15242424	0	Arginine	0,8	vasopressin	9,20	Arginine	vasopressin	CHEBI:29016	551	Chemical	Gene	START_ENTITY|dobj|concentrations concentrations|compound|END_ENTITY	Arginine vasopressin and serum nitrite/nitrate concentrations in advanced vasodilatory shock .
1794121	0	Arginine	0,8	vasopressin	9,20	Arginine	vasopressin	CHEBI:29016	551	Chemical	Gene	START_ENTITY|dobj|concentrations concentrations|compound|END_ENTITY	Arginine vasopressin concentrations in the cerebrospinal fluid of children .
1878201	0	Arginine	0,8	vasopressin	9,20	Arginine	vasopressin	CHEBI:29016	551	Chemical	Gene	stimulation|amod|START_ENTITY stimulation|compound|END_ENTITY	Arginine vasopressin stimulation of chloride secretion in Madin-Darby canine renal epithelial layers .
2266664	0	Arginine	0,8	vasopressin	9,20	Arginine	vasopressin	CHEBI:29016	551	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Arginine vasopressin gene expression in chronic_cardiac_failure in rats .
22882308	0	Arginine	0,8	vasopressin	137,148	Arginine	vasopressin	CHEBI:29016	551	Chemical	Gene	START_ENTITY|advcl|thirsting thirsting|nmod|suppression suppression|compound|END_ENTITY	Arginine vasopressin-dependent and AVP-independent mechanisms of renal fluid absorption during thirsting despite glucocorticoid-mediated vasopressin suppression .
2486890	0	Arginine	0,8	vasopressin	9,20	Arginine	vasopressin	CHEBI:29016	551	Chemical	Gene	intravascular|advmod|START_ENTITY intravascular|dep|END_ENTITY	Arginine vasopressin and acute , intravascular volume expansion in the human fetus .
26885186	0	Arginine	0,8	vasopressin	9,20	Arginine	vasopressin	CHEBI:29016	551	Chemical	Gene	tolvaptan|amod|START_ENTITY tolvaptan|compound|END_ENTITY	Arginine vasopressin antagonist tolvaptan in the treatment of heart_failure : a meta-analysis of randomized controlled trials .
2692374	0	Arginine	0,8	vasopressin	9,20	Arginine	vasopressin	CHEBI:29016	551	Chemical	Gene	secretion|amod|START_ENTITY secretion|compound|END_ENTITY	Arginine vasopressin secretion in non-obese women with polycystic_ovary_syndrome .
3953302	0	Arginine	0,8	vasopressin	9,20	Arginine	vasopressin	CHEBI:29016	551	Chemical	Gene	excretion|amod|START_ENTITY excretion|compound|END_ENTITY	Arginine vasopressin excretion in response to volume expansion in the healthy human , and in patients with glomerulonephritis .
7026596	0	Arginine	0,8	vasopressin	9,20	Arginine	vasopressin	CHEBI:29016	551	Chemical	Gene	START_ENTITY|dobj|response response|compound|END_ENTITY	Arginine vasopressin response to insulin-induced hypoglycemia in man .
8871886	0	Arginine	0,8	vasopressin	9,20	Arginine	vasopressin	CHEBI:29016	551	Chemical	Gene	START_ENTITY|dobj|calcium calcium|compound|END_ENTITY	Arginine vasopressin and oxytocin increase intracellular calcium and cAMP in human glomerular epithelial cells in culture .
9404718	0	Arginine	0,8	vasopressin	9,20	Arginine	vasopressin	CHEBI:29016	551	Chemical	Gene	depletion|compound|START_ENTITY depletion|compound|END_ENTITY	Arginine vasopressin -LRB- AVP -RRB- depletion in neurons of the suprachiasmatic nuclei affects the AVP content of the paraventricular neurons and stimulates adrenocorticotrophic hormone release .
9777911	0	Arginine	0,8	vasopressin	9,20	Arginine	vasopressin	CHEBI:29016	551	Chemical	Gene	START_ENTITY|dobj|levels levels|compound|END_ENTITY	Arginine vasopressin levels in nursing home residents with nighttime urinary incontinence .
25438555	0	Arginine-vasopressin	1,21	AVPR1A	37,43	Arginine-vasopressin	AVPR1A	MESH:D001127	552	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Arginine-vasopressin receptor gene -LRB- AVPR1A , AVPR1B -RRB- polymorphisms and their relation to personality traits -RSB- .
25508086	0	Arginine-vasopressin	1,21	AVPR1A	37,43	Arginine-vasopressin	AVPR1A	MESH:D001127	552	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Arginine-vasopressin receptor gene -LRB- AVPR1A , AVPR1B -RRB- polymorphisms and their relation to personality traits -RSB- .
9639422	0	Arginine_butyrate	0,17	bcr-abl	37,44	Arginine butyrate	bcr-abl	MESH:C033018	25	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	Arginine_butyrate downregulates p210 bcr-abl expression and induces apoptosis in chronic_myelogenous_leukemia cells .
9639422	0	Arginine_butyrate	0,17	p210	32,36	Arginine butyrate	p210	MESH:C033018	2125	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	Arginine_butyrate downregulates p210 bcr-abl expression and induces apoptosis in chronic_myelogenous_leukemia cells .
7161255	0	Arginyl	0,7	adrenodoxin_reductase	20,41	Arginyl	adrenodoxin reductase	CHEBI:22619	282604(Tax:9913)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Arginyl residues of adrenodoxin_reductase as the anion recognition site for 2 ' - phosphate group of NADP +1 .
25613820	0	Arglabin	84,92	NLRP3	67,72	Arglabin	NLRP3	MESH:C083346	216799(Tax:10090)	Chemical	Gene	Inhibitor|appos|START_ENTITY Inhibitor|compound|END_ENTITY	Anti-Inflammatory and Anti-Atherogenic Effects of the Inflammasome NLRP3 Inhibitor , Arglabin , in ApoE2.Ki Mice Fed a High Fat Diet .
26624894	0	Argon	0,5	Toll-Like_Receptor_2_and_4	78,104	Argon	Toll-Like Receptor 2 and 4	MESH:D001128	7097;7099	Chemical	Gene	Signaling|compound|START_ENTITY Signaling|nmod|END_ENTITY	Argon Mediates Anti-Apoptotic Signaling and Neuroprotection via Inhibition of Toll-Like_Receptor_2_and_4 .
18598941	0	Argyrin_a	0,9	p27	67,70	Argyrin a	p27	MESH:C530877	10534	Chemical	Gene	reveals|nsubj|START_ENTITY reveals|dobj|role role|nmod|END_ENTITY	Argyrin_a reveals a critical role for the tumor suppressor protein p27 -LRB- kip1 -RRB- in mediating antitumor activities in response to proteasome inhibition .
18679658	0	Aripiprazole	0,12	D1_and_serotonin_5-HT1A_receptors	97,130	Aripiprazole	D1 and serotonin 5-HT1A receptors	MESH:C094645	13370(Tax:10090)	Chemical	Gene	ameliorates|nsubj|START_ENTITY ameliorates|nmod|END_ENTITY	Aripiprazole ameliorates phencyclidine-induced impairment_of_recognition_memory through dopamine D1_and_serotonin_5-HT1A_receptors .
23968123	0	Aripiprazole	147,159	prolactin	204,213	Aripiprazole	prolactin	MESH:C094645	5617	Chemical	Gene	Agonist|appos|START_ENTITY Agonist|nmod|Management Management|nmod|END_ENTITY	Treating symptomatic hyperprolactinemia in women with schizophrenia : presentation of the ongoing DAAMSEL clinical trial -LRB- Dopamine partial Agonist , Aripiprazole , for the Management of Symptomatic ELevated prolactin -RRB- .
23983929	0	Aripiprazole	0,12	prolactin	109,118	Aripiprazole	prolactin	MESH:C094645	5617	Chemical	Gene	use|nsubj|START_ENTITY use|advcl|medication medication|dep|cases cases|acl|demonstrating demonstrating|dobj|ability ability|acl|reduce reduce|dobj|levels levels|compound|END_ENTITY	Aripiprazole use combined with depot antipsychotic medication : two cases demonstrating its ability to reduce prolactin levels in an adolescent forensic hospital .
21453692	0	Aristolochic_acid	0,17	matrix_metalloproteinase-9	42,68	Aristolochic acid	matrix metalloproteinase-9	MESH:C000228	4318	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	Aristolochic_acid downregulates monocytic matrix_metalloproteinase-9 by inhibiting nuclear factor-kB activation .
26183576	0	Aristolochic_acid_I	0,19	BCRP	38,42	Aristolochic acid I	BCRP	MESH:C000228	644079	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Aristolochic_acid_I Is a substrate of BCRP but not P-glycoprotein or MRP2 .
21554934	0	Aristolochic_acid_I	0,19	VEGF	61,65	Aristolochic acid I	VEGF	MESH:C000228	397157(Tax:9823)	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|amod|END_ENTITY	Aristolochic_acid_I and ochratoxin_A differentially regulate VEGF expression in porcine kidney epithelial cells -- the involvement of SP-1 and HIFs transcription factors .
9535168	0	Arisugacins	0,11	acetylcholinesterase	23,43	Arisugacins	acetylcholinesterase	null	43	Chemical	Gene	START_ENTITY|appos|inhibitors inhibitors|compound|END_ENTITY	Arisugacins , selective acetylcholinesterase inhibitors of microbial origin .
10724008	0	Arisugacins_C_and_D	0,19	acetylcholinesterase	27,47	Arisugacins C and D	acetylcholinesterase	null	43	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Arisugacins_C_and_D , novel acetylcholinesterase inhibitors and their related novel metabolites produced by Penicilium sp .
22172677	2	Arl8-GTP	234,242	SKIP	272,276	Arl8-GTP	SKIP	null	23207	Chemical	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	By using affinity chromatography , we find that Arl8-GTP binds to the soluble protein SKIP -LRB- SifA_and_kinesin-interacting_protein , aka PLEKHM2 -RRB- .
25420534	0	Armillarisin_A	15,29	IL-1b	39,44	Armillarisin A	IL-1b	MESH:C023435	3553	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	The Effects of Armillarisin_A on Serum IL-1b and IL-4 and in Treating Ulcerative_Colitis .
26190026	0	Aroclor_1254	20,32	Insulin_Receptor	97,113	Aroclor 1254	Insulin Receptor	MESH:D020111	16337(Tax:10090)	Chemical	Gene	Homeostasis|compound|START_ENTITY Exposure|nmod|Homeostasis Exposure|nmod|Pathway Pathway|compound|END_ENTITY	Chronic Exposure to Aroclor_1254 Disrupts Glucose Homeostasis in Male Mice via Inhibition of the Insulin_Receptor Signal Pathway .
19772856	0	Aroclor_1254	61,73	cytochrome_P450	29,44	Aroclor 1254	cytochrome P450	MESH:D020111	13079(Tax:10090)	Chemical	Gene	activities|nmod|START_ENTITY activities|amod|END_ENTITY	Hyper - and hypo-induction of cytochrome_P450 activities with Aroclor_1254 and 3-methylcholanthrene in Cyp1a2 -LRB- - / - -RRB- mice .
14997283	0	Aroclor_1254	0,12	tryptophan_hydroxylase	22,44	Aroclor 1254	tryptophan hydroxylase	MESH:D020111	24848(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Aroclor_1254 inhibits tryptophan_hydroxylase activity in rat brain .
25261288	0	Aromatic_aldehydes	0,18	oxidoreductase	50,64	Aromatic aldehydes	oxidoreductase	null	7296	Chemical	Gene	START_ENTITY|nmod|site site|nmod|END_ENTITY	Aromatic_aldehydes at the active site of aldehyde oxidoreductase from Desulfovibrio gigas : reactivity and molecular details of the enzyme-substrate and enzyme-product interaction .
9311612	0	Arotinoid_mofarotene	0,20	p21	46,49	Arotinoid mofarotene	p21	null	1026	Chemical	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|END_ENTITY	Arotinoid_mofarotene -LRB- RO40-8757 -RRB- up-regulates p21 and p27 during growth inhibition of pancreatic_cancer cell lines .
19765857	0	Arsenic	0,7	AtPCS1	20,26	Arsenic	AtPCS1	MESH:D001151	831845(Tax:3702)	Chemical	Gene	response|amod|START_ENTITY response|nmod|END_ENTITY	Arsenic response of AtPCS1 - and CePCS-expressing plants - effects of external As -LRB- V -RRB- concentration on As-accumulation pattern and NPT metabolism .
19410645	0	Arsenic	0,7	Camk4	41,46	Arsenic	Camk4	MESH:D001151	12326(Tax:10090)	Chemical	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|nmod|END_ENTITY	Arsenic down-regulates the expression of Camk4 , an important gene related to cerebellar LTD in mice .
19168569	0	Arsenic	0,7	EGFR	18,22	Arsenic	EGFR	MESH:D001151	1956	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|pathway pathway|amod|END_ENTITY	Arsenic activates EGFR pathway signaling in the lung .
26573582	0	Arsenic	0,7	GLI	19,22	Arsenic	GLI	MESH:D001151	2735	Chemical	Gene	Attenuates|compound|START_ENTITY END_ENTITY|nsubj|Attenuates	Arsenic Attenuates GLI Signaling , Increasing or Decreasing its Transcriptional Program in a Context Dependent Manner .
18539681	0	Arsenic	0,7	MMP-9	20,25	Arsenic	MMP-9	MESH:D001151	4318	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	Arsenic upregulates MMP-9 and inhibits wound repair in human airway epithelial cells .
25815309	0	Arsenic	60,67	Nrf2	72,76	Arsenic	Nrf2	MESH:D001151	18024(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|Signaling Signaling|compound|END_ENTITY	Lutein Has a Protective Effect on Hepatotoxicity Induced by Arsenic via Nrf2 Signaling .
20207026	0	Arsenic	0,7	SGK1	17,21	Arsenic	SGK1	MESH:D001151	105930542	Chemical	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Arsenic inhibits SGK1 activation of CFTR Cl - channels in the gill of killifish , Fundulus_heteroclitus .
14668793	0	Arsenic	0,7	interferon_gamma	44,60	Arsenic	interferon gamma	MESH:D001151	3458	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Arsenic enhances the activation of Stat1 by interferon_gamma leading to synergistic expression of IRF-1 .
22488045	0	Arsenic	0,7	interleukin-6	36,49	Arsenic	interleukin-6	MESH:D001151	16193(Tax:10090)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Arsenic modulates heme_oxygenase-1 , interleukin-6 , and vascular_endothelial_growth_factor expression in endothelial cells : roles of ROS , NF-kB , and MAPK pathways .
10491313	0	Arsenic	0,7	p53	36,39	Arsenic	p53	MESH:D001151	7157	Chemical	Gene	disrupts|nsubj|START_ENTITY disrupts|dobj|levels levels|nmod|END_ENTITY	Arsenic disrupts cellular levels of p53 and mdm2 : a potential mechanism of carcinogenesis .
17945324	0	Arsenic	0,7	p53	71,74	Arsenic	p53	MESH:D001151	7157	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Arsenic promotes centrosome_abnormalities and cell colony formation in p53 compromised human lung cells .
9219564	0	Arsenic	0,7	p53	90,93	Arsenic	p53	MESH:D001151	7157	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|patterns patterns|nmod|promoter promoter|nmod|END_ENTITY	Arsenic alters cytosine methylation patterns of the promoter of the tumor suppressor gene p53 in human lung cells : a model for a mechanism of carcinogenesis .
23108036	0	Arsenic	0,7	peroxisome_proliferator-activated_receptor_gamma	93,141	Arsenic	peroxisome proliferator-activated receptor gamma	MESH:D001151	5468	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Arsenic inhibits the adipogenic differentiation of mesenchymal stem cells by down-regulating peroxisome_proliferator-activated_receptor_gamma and CCAAT enhancer-binding proteins .
25344585	0	Arsenic_Trioxide	18,34	AMPK	38,42	Arsenic Trioxide	AMPK	MESH:C006632	5563	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Direct Binding of Arsenic_Trioxide to AMPK and Generation of Inhibitory Effects on Acute Myeloid_Leukemia Precursors .
23008787	0	Arsenic_Trioxide	98,114	Thrombomodulin	76,90	Arsenic Trioxide	Thrombomodulin	MESH:C006632	7056	Chemical	Gene	Treatment|compound|START_ENTITY END_ENTITY|nmod|Treatment	Successful Control of Disseminated_Intravascular_Coagulation by Recombinant Thrombomodulin during Arsenic_Trioxide Treatment in Relapsed Patient with Acute_Promyelocytic_Leukemia .
18566239	0	Arsenic_trioxide	0,16	AKT	27,30	Arsenic trioxide	AKT	MESH:C006632	207	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|protein protein|compound|END_ENTITY	Arsenic_trioxide decreases AKT protein in a caspase-dependent manner .
24392034	0	Arsenic_trioxide	0,16	AKT	68,71	Arsenic trioxide	AKT	MESH:C006632	207	Chemical	Gene	overcomes|nsubj|START_ENTITY overcomes|dobj|activation activation|nmod|END_ENTITY	Arsenic_trioxide overcomes rapamycin-induced feedback activation of AKT and ERK signaling to enhance the anti-tumor effects in breast_cancer .
25416439	0	Arsenic_trioxide	0,16	Akt	116,119	Arsenic trioxide	Akt	MESH:C006632	207	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|advcl|inhibiting inhibiting|dobj|activation activation|compound|END_ENTITY	Arsenic_trioxide potentiates the anti-cancer activities of sorafenib against hepatocellular_carcinoma by inhibiting Akt activation .
25869069	0	Arsenic_trioxide	0,16	Akt	147,150	Arsenic trioxide	Akt	MESH:C006632	207	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|advcl|inactivating inactivating|dobj|END_ENTITY	Arsenic_trioxide synergistically potentiates the cytotoxic effect of fludarabine in chronic_lymphocytic_leukemia cells by further inactivating the Akt and ERK signaling pathways .
15735709	0	Arsenic_trioxide	0,16	Bax	69,72	Arsenic trioxide	Bax	MESH:C006632	581	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Arsenic_trioxide -LRB- As -LRB- 2 -RRB- O -LRB- 3 -RRB- -RRB- induces apoptosis through activation of Bax in hematopoietic cells .
16613325	0	Arsenic_trioxide	0,16	DNA_methyltransferase	26,47	Arsenic trioxide	DNA methyltransferase	MESH:C006632	1786	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|genes genes|compound|END_ENTITY	Arsenic_trioxide inhibits DNA_methyltransferase and restores methylation-silenced genes in human liver_cancer cells .
24993472	0	Arsenic_trioxide	0,16	DNA_methyltransferase	26,47	Arsenic trioxide	DNA methyltransferase	MESH:C006632	1786	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Arsenic_trioxide inhibits DNA_methyltransferase and restores TMS1 gene expression in K562 cells .
24944602	0	Arsenic_trioxide	0,16	EVI-1	75,80	Arsenic trioxide	EVI-1	MESH:C006632	2122	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|downregulating downregulating|dobj|END_ENTITY	Arsenic_trioxide induces apoptosis in the THP1 cell line by downregulating EVI-1 .
15203277	0	Arsenic_trioxide	0,16	EVI1	175,179	Arsenic trioxide	EVI1	MESH:C006632	2122	Chemical	Gene	combination|amod|START_ENTITY produces|nsubj|combination produces|advcl|patients patients|nmod|those those|nmod|expression expression|compound|END_ENTITY	Arsenic_trioxide and thalidomide combination produces multi-lineage hematological responses in myelodysplastic_syndromes patients , particularly in those with high pre-therapy EVI1 expression .
24420698	0	Arsenic_trioxide	0,16	Gli1	121,125	Arsenic trioxide	Gli1	MESH:C006632	2735	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	Arsenic_trioxide inhibits tumor cell growth in malignant_rhabdoid_tumors in vitro and in vivo by targeting overexpressed Gli1 .
15978632	0	Arsenic_trioxide	0,16	Hsp70	25,30	Arsenic trioxide	Hsp70	MESH:C006632	3308	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Arsenic_trioxide induces Hsp70 expression via reactive oxygen species and JNK pathway in MDA231 cells .
20799280	0	Arsenic_trioxide	0,16	JNK_and_ERK	43,54	Arsenic trioxide	JNK and ERK	MESH:C006632	5599;5594	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Arsenic_trioxide induces apoptosis through JNK_and_ERK in human mesothelioma cells .
15547942	0	Arsenic_trioxide	0,16	NF-kappaB	54,63	Arsenic trioxide	NF-kappaB	MESH:C006632	4790	Chemical	Gene	represses|amod|START_ENTITY constitutive|nsubj|represses constitutive|dobj|activation activation|nmod|expression expression|amod|END_ENTITY	Arsenic_trioxide represses constitutive activation of NF-kappaB and COX-2 expression in human acute_myeloid_leukemia , HL-60 .
16277838	0	Arsenic_trioxide	1,17	NF-kappaB	62,71	Arsenic trioxide	NF-kappaB	MESH:C006632	4790	Chemical	Gene	induced|nsubj|START_ENTITY induced|xcomp|relative relative|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Arsenic_trioxide induced leukemic cell apoptosis relative to NF-kappaB activation -RSB- .
17178007	0	Arsenic_trioxide	0,16	NF-kappaB	40,49	Arsenic trioxide	NF-kappaB	MESH:C006632	18033(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Arsenic_trioxide , a potent inhibitor of NF-kappaB , abrogates allergen-induced airway hyperresponsiveness and inflammation .
17384263	0	Arsenic_trioxide	0,16	NF-kappaB	27,36	Arsenic trioxide	NF-kappaB	MESH:C006632	4790	Chemical	Gene	represses|nsubj|START_ENTITY represses|dobj|activation activation|amod|END_ENTITY	Arsenic_trioxide represses NF-kappaB activation and increases apoptosis in ATRA-treated APL cells .
23387208	0	Arsenic_trioxide	1,17	NF-kappaB	126,135	Arsenic trioxide	NF-kappaB	MESH:C006632	4790	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dep|inducing inducing|nmod|expression expression|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Arsenic_trioxide enhances TRAIL inducing human lung_cancer cell line A549 cells apoptosis by down-regulate the expression of NF-kappaB -RSB- .
24993472	0	Arsenic_trioxide	0,16	TMS1	61,65	Arsenic trioxide	TMS1	MESH:C006632	10955	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Arsenic_trioxide inhibits DNA_methyltransferase and restores TMS1 gene expression in K562 cells .
19781379	0	Arsenic_trioxide	0,16	annexin_II	49,59	Arsenic trioxide	annexin II	MESH:C006632	302	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|nmod|END_ENTITY	Arsenic_trioxide downregulates the expression of annexin_II in bone marrow cells from patients with acute_myelogenous_leukemia .
22977528	0	Arsenic_trioxide	0,16	caspase-3	96,105	Arsenic trioxide	caspase-3	MESH:C006632	836	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Arsenic_trioxide induces the apoptosis of human breast_cancer MCF-7 cells through activation of caspase-3 and inhibition of HERG channels .
10428472	0	Arsenic_trioxide	0,16	caspase_3	89,98	Arsenic trioxide	caspase 3	MESH:C006632	836	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Arsenic_trioxide induces apoptosis in neuroblastoma cell lines through the activation of caspase_3 in vitro .
21308489	0	Arsenic_trioxide	0,16	catalase	97,105	Arsenic trioxide	catalase	MESH:C006632	847	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|inhibition inhibition|nmod|END_ENTITY	Arsenic_trioxide induces apoptosis of p53 null osteosarcoma MG63 cells through the inhibition of catalase .
23949314	0	Arsenic_trioxide	0,16	cyclin_D1	70,79	Arsenic trioxide	cyclin D1	MESH:C006632	595	Chemical	Gene	suppressed|nsubj|START_ENTITY suppressed|nmod|downregulation downregulation|nmod|END_ENTITY	Arsenic_trioxide suppressed mantle cell lymphoma by downregulation of cyclin_D1 .
19088370	0	Arsenic_trioxide	0,16	estrogen_receptor-alpha	48,71	Arsenic trioxide	estrogen receptor-alpha	MESH:C006632	2099	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Arsenic_trioxide -LRB- As2O3 -RRB- inhibits expression of estrogen_receptor-alpha through regulation of the mitogen-activated protein kinase -LRB- MAPK -RRB- pathway in endometrial_cancer cells .
25824027	0	Arsenic_trioxide	0,16	hERG	71,75	Arsenic trioxide	hERG	MESH:C006632	2078	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|parataxis|END_ENTITY	Arsenic_trioxide inhibits breast_cancer cell growth via microRNA -328 / hERG pathway in MCF -7 cells .
25436934	0	Arsenic_trioxide	0,16	hTERT	45,50	Arsenic trioxide	hTERT	MESH:C006632	7015	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|transcription transcription|nmod|END_ENTITY	Arsenic_trioxide suppresses transcription of hTERT through down-regulation of multiple transcription factors in HL-60 leukemia cells .
24680928	0	Arsenic_trioxide	0,16	microRNA-491	115,127	Arsenic trioxide	microRNA-491	MESH:C006632	574444	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|nmod|END_ENTITY	Arsenic_trioxide attenuates the invasion potential of human liver_cancer cells through the demethylation-activated microRNA-491 .
14642128	0	Arsenic_trioxide	0,16	p-glycoprotein	26,40	Arsenic trioxide	p-glycoprotein	MESH:C006632	5243	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Arsenic_trioxide inhibits p-glycoprotein expression in multidrug-resistant human leukemia cells that overexpress the MDR1 gene .
12667347	0	Arsenic_trioxide	1,17	p15INK4B	26,34	Arsenic trioxide	p15INK4B	MESH:C006632	1030	Chemical	Gene	induced|nsubj|START_ENTITY induced|dobj|expression expression|amod|END_ENTITY	-LSB- Arsenic_trioxide induced p15INK4B gene expression in myelodysplastic_syndrome cell line MUTZ-1 -RSB- .
11146441	0	Arsenic_trioxide	0,16	p53	90,93	Arsenic trioxide	p53	MESH:C006632	7157	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|up-regulation up-regulation|nmod|END_ENTITY	Arsenic_trioxide induces apoptosis in human gastric_cancer cells through up-regulation of p53 and activation of caspase-3 .
12490120	0	Arsenic_trioxide	1,17	p53	54,57	Arsenic trioxide	p53	MESH:C006632	7157	Chemical	Gene	induced|nsubj|START_ENTITY induced|dobj|apoptosis apoptosis|nmod|genes genes|compound|END_ENTITY	-LSB- Arsenic_trioxide induced apoptosis and expression of p53 and bcl-2 genes in human small_cell_lung_cancer cells -RSB- .
12851490	0	Arsenic_trioxide	0,16	p53	162,165	Arsenic trioxide	p53	MESH:C006632	7157	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|apoptosis apoptosis|nmod|pathway pathway|acl|engaging engaging|nmod|END_ENTITY	Arsenic_trioxide selectively induces early and extensive apoptosis via the APO2/caspase -8 pathway engaging the mitochondrial pathway in myeloma cells with mutant p53 .
17332940	0	Arsenic_trioxide	0,16	p53	178,181	Arsenic trioxide	p53	MESH:C006632	7157	Chemical	Gene	induces|nsubj|START_ENTITY induces|parataxis|activated activated|nmod|cells cells|acl|expressing expressing|dobj|END_ENTITY	Arsenic_trioxide induces p53-dependent apoptotic signals in myeloma cells with SiRNA-silenced p53 : MAP kinase pathway is preferentially activated in cells expressing inactivated p53 .
17332940	0	Arsenic_trioxide	0,16	p53	94,97	Arsenic trioxide	p53	MESH:C006632	7157	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Arsenic_trioxide induces p53-dependent apoptotic signals in myeloma cells with SiRNA-silenced p53 : MAP kinase pathway is preferentially activated in cells expressing inactivated p53 .
17530438	0	Arsenic_trioxide	0,16	p53	134,137	Arsenic trioxide	p53	MESH:C006632	7157	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|profiles profiles|nmod|genes genes|acl|related related|nmod|cells cells|amod|dependent dependent|nmod|status status|compound|END_ENTITY	Arsenic_trioxide induces different gene expression profiles of genes related to growth and apoptosis in glioma cells dependent on the p53 status .
21308489	0	Arsenic_trioxide	0,16	p53	38,41	Arsenic trioxide	p53	MESH:C006632	7157	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|apoptosis apoptosis|nmod|cells cells|nummod|END_ENTITY	Arsenic_trioxide induces apoptosis of p53 null osteosarcoma MG63 cells through the inhibition of catalase .
25116336	0	Arsenic_trioxide	0,16	p53	72,75	Arsenic trioxide	p53	MESH:C006632	7157	Chemical	Gene	reactivates|nsubj|START_ENTITY reactivates|dobj|degradation degradation|nmod|protein protein|compound|END_ENTITY	Arsenic_trioxide reactivates proteasome-dependent degradation of mutant p53 protein in cancer cells in part via enhanced expression of Pirh2 E3 ligase .
19763917	0	Arsenic_trioxide	0,16	p73	112,115	Arsenic trioxide	p73	MESH:C006632	7161	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|up-regulation up-regulation|nmod|END_ENTITY	Arsenic_trioxide induces apoptosis in NB-4 , an acute_promyelocytic_leukemia cell line , through up-regulation of p73 via suppression of nuclear_factor_kappa_B-mediated inhibition of p73 transcription and prevention of NF-kappaB-mediated induction of XIAP , cIAP2 , BCL-XL and survivin .
21594580	0	Arsenic_trioxide	0,16	survivin	118,126	Arsenic trioxide	survivin	MESH:C006632	11799(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|downregulation downregulation|nmod|END_ENTITY	Arsenic_trioxide induces autophagy and apoptosis in human glioma cells in vitro and in vivo through downregulation of survivin .
20336670	0	Arsenite	0,8	Akt	35,38	Arsenite	Akt	MESH:C015001	11651(Tax:10090)	Chemical	Gene	causes|nsubj|START_ENTITY causes|dobj|down-regulation down-regulation|nmod|END_ENTITY	Arsenite causes down-regulation of Akt and c-Fos , cell cycle dysfunction and apoptosis in glutathione-deficient cells .
23566955	0	Arsenite	0,8	BMP	24,27	Arsenite	BMP	MESH:C015001	649	Chemical	Gene	suppression|amod|START_ENTITY suppression|nmod|END_ENTITY	Arsenite suppression of BMP signaling in human keratinocytes .
15630080	0	Arsenite	0,8	CYP1A1	23,29	Arsenite	CYP1A1	MESH:C015001	13076(Tax:10090)	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|induction induction|nummod|END_ENTITY	Arsenite inhibition of CYP1A1 induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin is independent of cell cycle arrest .
15833926	0	Arsenite	0,8	CYP3A4	19,25	Arsenite	CYP3A4	MESH:C015001	1576	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|END_ENTITY	Arsenite decreases CYP3A4 and RXRalpha in primary human hepatocytes .
19084030	0	Arsenite	0,8	CYP3A4	123,129	Arsenite	CYP3A4	MESH:C015001	1576	Chemical	Gene	modify|nsubj|START_ENTITY modify|xcomp|expression expression|nmod|intestine intestine|nmod|transgenic_mice transgenic_mice|compound|END_ENTITY	Arsenite and its metabolites , MMA -LRB- III -RRB- and DMA -LRB- III -RRB- , modify CYP3A4 , PXR and RXR_alpha expression in the small intestine of CYP3A4 transgenic_mice .
19084030	0	Arsenite	0,8	CYP3A4	60,66	Arsenite	CYP3A4	MESH:C015001	1576	Chemical	Gene	modify|nsubj|START_ENTITY modify|xcomp|expression expression|nsubj|END_ENTITY	Arsenite and its metabolites , MMA -LRB- III -RRB- and DMA -LRB- III -RRB- , modify CYP3A4 , PXR and RXR_alpha expression in the small intestine of CYP3A4 transgenic_mice .
16121039	0	Arsenite	0,8	Cystic_Fibrosis_Transmembrane_Conductance_Regulator	19,70	Arsenite	Cystic Fibrosis Transmembrane Conductance Regulator	MESH:C015001	1080	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Arsenite regulates Cystic_Fibrosis_Transmembrane_Conductance_Regulator and P-glycoprotein : evidence of pathway independence .
14971644	0	Arsenite	0,8	HIF-1alpha	17,27	Arsenite	HIF-1alpha	MESH:C015001	3091	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Arsenite induces HIF-1alpha and VEGF through PI3K , Akt and reactive oxygen species in DU145 human prostate_carcinoma cells .
24004609	0	Arsenite	0,8	IL-6	16,20	Arsenite	IL-6	MESH:C015001	3569	Chemical	Gene	secretion|amod|START_ENTITY secretion|compound|END_ENTITY	Arsenite evokes IL-6 secretion , autocrine regulation of STAT3 signaling , and miR-21 expression , processes involved in the EMT and malignant transformation of human bronchial epithelial cells .
11835394	0	Arsenite	0,8	IkappaBalpha	20,32	Arsenite	IkappaBalpha	MESH:C015001	4792	Chemical	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	Arsenite stabilizes IkappaBalpha and prevents NF-kappaB activation in IL-1_beta-stimulated Caco-2 cells independent of the heat_shock response .
18633435	0	Arsenite	0,8	Notch1	20,26	Arsenite	Notch1	MESH:C015001	4851	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	Arsenite suppresses Notch1 signaling in human keratinocytes .
19733843	0	Arsenite	0,8	aquaglyceroporin_9	17,35	Arsenite	aquaglyceroporin 9	MESH:C015001	64008(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Arsenite induces aquaglyceroporin_9 expression in murine livers .
11835400	0	Arsenite	0,8	cyclooxygenase-2	20,36	Arsenite	cyclooxygenase-2	MESH:C015001	5743	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Arsenite stimulates cyclooxygenase-2 expression through activating IkappaB kinase and nuclear factor kappaB in primary and ECV304 endothelial cells .
11911489	0	Arsenite	0,8	cyclooxygenase-2	116,132	Arsenite	cyclooxygenase-2	MESH:C015001	5743	Chemical	Gene	benzo|compound|START_ENTITY -LSB-|nsubj|benzo -LSB-|advcl|decreasing decreasing|dobj|levels levels|amod|END_ENTITY	Arsenite pretreatment attenuates benzo -LSB- a -RSB- pyrene cytotoxicity in a human lung_adenocarcinoma cell line by decreasing cyclooxygenase-2 levels .
16239170	0	Arsenite	0,8	endothelial_nitric_oxide_synthase	73,106	Arsenite	endothelial nitric oxide synthase	MESH:C015001	4846	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|down-regulation down-regulation|nmod|END_ENTITY	Arsenite induces endothelial cytotoxicity by down-regulation of vascular endothelial_nitric_oxide_synthase .
12241537	0	Arsenite	0,8	interleukin-6	18,31	Arsenite	interleukin-6	MESH:C015001	3569	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Arsenite inhibits interleukin-6 production in human intestinal epithelial cells by down-regulating nuclear_factor-kappaB activity .
8556713	0	Arsenite	0,8	ornithine_decarboxylase	35,58	Arsenite	ornithine decarboxylase	MESH:C015001	24609(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|activity activity|amod|END_ENTITY	Arsenite , but not cadmium , induces ornithine_decarboxylase and heme oxygenase activity in rat liver : relevance to arsenic_carcinogenesis .
16739126	0	Arsenite	0,8	p53	18,21	Arsenite	p53	MESH:C015001	22060(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Arsenite inhibits p53 phosphorylation , DNA binding activity , and p53 target gene p21 expression in mouse epidermal JB6 cells .
19931552	0	Arsenite	0,8	p53	51,54	Arsenite	p53	MESH:C015001	7157	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Arsenite promotes centrosome abnormalities under a p53 compromised status induced by 4 - -LRB- methylnitrosamino -RRB- -1 - -LRB- 3-pyridyl -RRB- -1 - butanone -LRB- NNK -RRB- .
18784357	0	Artemisinin	0,11	estrogen_receptor-alpha	55,78	Artemisinin	estrogen receptor-alpha	MESH:C031327	2099	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|levels levels|nmod|END_ENTITY	Artemisinin selectively decreases functional levels of estrogen_receptor-alpha and ablates estrogen-induced proliferation in human breast_cancer cells .
21039753	0	Artemisinin	0,11	extracellular_matrix_metalloproteinase_inducer	21,67	Artemisinin	extracellular matrix metalloproteinase inducer	MESH:C031327	682	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Artemisinin inhibits extracellular_matrix_metalloproteinase_inducer -LRB- EMMPRIN -RRB- and matrix_metalloproteinase-9 expression via a protein kinase C / p38/extracellular _ signal-regulated_kinase pathway in phorbol_myristate_acetate-induced THP-1 macrophages .
17669364	0	Artemisolide	0,12	IkappaB_kinase_beta	39,58	Artemisolide	IkappaB kinase beta	MESH:C513233	16150(Tax:10090)	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Artemisolide is a typical inhibitor of IkappaB_kinase_beta targeting cysteine-179 residue and down-regulates NF-kappaB-dependent TNF-alpha expression in LPS-activated macrophages .
22227297	0	Artesunate	0,10	ERK	77,80	Artesunate	ERK	MESH:C039726	5594	Chemical	Gene	activates|nsubj|START_ENTITY activates|nmod|END_ENTITY	Artesunate activates Nrf2 pathway-driven anti-inflammatory potential through ERK signaling in microglial BV2 cells .
19950591	0	Artesunate	12,22	MCP-1	26,31	Artesunate	MCP-1	MESH:C039726	100360872	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effects of Artesunate on MCP-1 and MCP-1 mRNA expression of renal tissue in the rat IgA_nephropathy model -RSB- .
17459108	0	Arvanil	0,7	CB1	90,93	Arvanil	CB1	MESH:C121153	12801(Tax:10090)	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|nmod|END_ENTITY	Arvanil , anandamide and N-arachidonoyl-dopamine -LRB- NADA -RRB- inhibit emesis through cannabinoid CB1 and vanilloid TRPV1 receptors in the ferret .
17360047	0	Arvanil	0,7	CD36	35,39	Arvanil	CD36	MESH:C121153	948	Chemical	Gene	START_ENTITY|dobj|expression expression|compound|END_ENTITY	Arvanil and anandamide up-regulate CD36 expression in human peripheral blood mononuclear cells .
26435072	0	Aryl_Bis-Sulfonamide	0,20	IspF	35,39	Aryl Bis-Sulfonamide	IspF	null	842700(Tax:3702)	Chemical	Gene	Inhibitors|amod|START_ENTITY Inhibitors|nmod|END_ENTITY	Aryl_Bis-Sulfonamide Inhibitors of IspF from Arabidopsis_thaliana and Plasmodium_falciparum .
25658813	0	Aryl_Hydrocarbon	14,30	AIP	61,64	Aryl Hydrocarbon	AIP	null	9049	Chemical	Gene	Protein|compound|START_ENTITY Protein|appos|END_ENTITY	Regulation of Aryl_Hydrocarbon Receptor Interacting Protein -LRB- AIP -RRB- Protein Expression by MiR-34a in Sporadic_Somatotropinomas .
25258701	0	Aryl_Hydrocarbon	74,90	AhR	101,104	Aryl Hydrocarbon	AhR	null	196	Chemical	Gene	Receptor|compound|START_ENTITY Receptor|appos|END_ENTITY	Cancer-promoting and Inhibiting Effects of Dietary Compounds : Role of the Aryl_Hydrocarbon Receptor -LRB- AhR -RRB- .
26215100	0	Aryl_Hydrocarbon	80,96	AhR	107,110	Aryl Hydrocarbon	AhR	null	11622(Tax:10090)	Chemical	Gene	Receptor|compound|START_ENTITY Receptor|appos|END_ENTITY	Screening a Mouse Liver Gene Expression Compendium Identifies Modulators of the Aryl_Hydrocarbon Receptor -LRB- AhR -RRB- .
6275573	0	Aryl_hydrocarbon	0,16	AHH	30,33	Aryl hydrocarbon	AHH	null	24296(Tax:10116)	Chemical	Gene	hydroxylase|compound|START_ENTITY hydroxylase|appos|END_ENTITY	Aryl_hydrocarbon hydroxylase -LRB- AHH -RRB- induction by polybrominated_biphenyls -LRB- PBBs -RRB- : enchancement by photolysis .
16111922	0	Aryl_hydrocarbon	0,16	AHR	27,30	Aryl hydrocarbon	AHR	null	196	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Aryl_hydrocarbon receptor -LRB- AHR -RRB- and AHR nuclear translocator -LRB- ARNT -RRB- expression in Baikal_seal -LRB- Pusa_sibirica -RRB- and association with 2,3,7,8-TCDD toxic equivalents and CYP1 expression levels .
20420666	0	Aryl_hydrocarbon	0,16	AHR	27,30	Aryl hydrocarbon	AHR	null	25690(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Aryl_hydrocarbon receptor -LRB- AHR -RRB- - regulated transcriptomic changes in rats sensitive or resistant to major dioxin toxicities .
22879383	0	Aryl_hydrocarbon	0,16	AHR	27,30	Aryl hydrocarbon	AHR	null	196	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Aryl_hydrocarbon receptor -LRB- AHR -RRB- - active pharmaceuticals are selective AHR modulators in MDA-MB-468 and BT474 breast_cancer cells .
26944194	0	Aryl_hydrocarbon	0,16	AHR	27,30	Aryl hydrocarbon	AHR	null	196	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Aryl_hydrocarbon receptor -LRB- AHR -RRB- regulation of L-Type Amino_Acid Transporter 1 -LRB- LAT-1 -RRB- expression in MCF-7 and MDA-MB-231 breast_cancer cells .
9230184	0	Aryl_hydrocarbon	0,16	AHR	41,44	Aryl hydrocarbon	AHR	null	11622(Tax:10090)	Chemical	Gene	mice|amod|START_ENTITY mice|dep|END_ENTITY	Aryl_hydrocarbon receptor knockout mice -LRB- AHR - / - -RRB- exhibit liver retinoid accumulation and reduced retinoic_acid metabolism .
26872613	0	Aryl_hydrocarbon	110,126	AIP	157,160	Aryl hydrocarbon	AIP	null	282827(Tax:10116)	Chemical	Gene	Protein|compound|START_ENTITY Protein|appos|END_ENTITY	Expression of Peroxisome_Proliferator-Activated_Receptor_alpha -LRB- PPARa -RRB- in somatotropinomas : Relationship with Aryl_hydrocarbon receptor Interacting Protein -LRB- AIP -RRB- and in vitro effects of fenofibrate in GH3 cells .
11243847	0	Aryl_hydrocarbon	0,16	AhR	27,30	Aryl hydrocarbon	AhR	null	11622(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Aryl_hydrocarbon receptor -LRB- AhR -RRB- - mediated induction of xanthine_oxidase / xanthine_dehydrogenase activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin .
11453109	0	Aryl_hydrocarbon	0,16	AhR	27,30	Aryl hydrocarbon	AhR	null	196	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Aryl_hydrocarbon receptor -LRB- AhR -RRB- - linked inhibition of luteal cell progesterone secretion in 2,3,7,8-tetrachlorodibenzo-p-dioxin treated cells .
14678569	0	Aryl_hydrocarbon	0,16	AhR	27,30	Aryl hydrocarbon	AhR	null	196	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Aryl_hydrocarbon receptor -LRB- AhR -RRB- agonists suppress interleukin-6 expression by bone marrow stromal cells : an immunotoxicology study .
15533795	0	Aryl_hydrocarbon	0,16	AhR	27,30	Aryl hydrocarbon	AhR	null	196	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Aryl_hydrocarbon receptor -LRB- AhR -RRB- - independent effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- on softshell clam -LRB- Mya arenaria -RRB- reproductive tissue .
17879099	0	Aryl_hydrocarbon	0,16	AhR	27,30	Aryl hydrocarbon	AhR	null	11622(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Aryl_hydrocarbon receptor -LRB- AhR -RRB- - mediated reporter gene expression systems in transgenic tobacco plants .
22273745	0	Aryl_hydrocarbon	0,16	AhR	27,30	Aryl hydrocarbon	AhR	null	11622(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Aryl_hydrocarbon receptor -LRB- AhR -RRB- regulates silica-induced inflammation but not fibrosis .
24469321	0	Aryl_hydrocarbon	0,16	AhR	27,30	Aryl hydrocarbon	AhR	null	196	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Aryl_hydrocarbon receptor -LRB- AhR -RRB- agonists increase airway epithelial matrix metalloproteinase activity .
24795504	0	Aryl_hydrocarbon	0,16	AhR	27,30	Aryl hydrocarbon	AhR	null	196	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Aryl_hydrocarbon receptor -LRB- AhR -RRB- modulates cockroach allergen-induced immune responses through active TGFb1 release .
26417045	0	Aryl_hydrocarbon	79,95	AhR	106,109	Aryl hydrocarbon	AhR	null	11622(Tax:10090)	Chemical	Gene	Receptor|compound|START_ENTITY Receptor|appos|END_ENTITY	Leflunomide Induces Pulmonary and Hepatic Cytochrome_P450 _ -LRB- CYP -RRB- _ 1A Enzymes via Aryl_hydrocarbon Receptor -LRB- AhR -RRB- .
24086407	0	Aryl_hydrocarbon	0,16	HuR	57,60	Aryl hydrocarbon	HuR	null	1994	Chemical	Gene	retention|amod|START_ENTITY retention|nmod|END_ENTITY	Aryl_hydrocarbon receptor-dependent retention of nuclear HuR suppresses cigarette smoke-induced cyclooxygenase-2 expression independent of DNA-binding .
26621329	0	Aryl_hydrocarbon	0,16	LAT1	94,98	Aryl hydrocarbon	LAT1	null	8140	Chemical	Gene	up-regulation|amod|START_ENTITY up-regulation|nmod|END_ENTITY	Aryl_hydrocarbon receptor-dependent up-regulation of the heterodimeric amino_acid transporter LAT1 -LRB- SLC7A5 -RRB- / CD98hc -LRB- SLC3A2 -RRB- by diesel exhaust particle extract in human bronchial epithelial cells .
21890736	0	Aryl_hydrocarbon	0,16	Stearoyl-CoA_desaturase_1	48,73	Aryl hydrocarbon	Stearoyl-CoA desaturase 1	null	20249(Tax:10090)	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Aryl_hydrocarbon receptor-mediated induction of Stearoyl-CoA_desaturase_1 alters hepatic fatty_acid composition in TCDD-elicited steatosis .
9380021	0	Aryl_hydrocarbon	0,16	cyp1a1	49,55	Aryl hydrocarbon	cyp1a1	null	13076(Tax:10090)	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Aryl_hydrocarbon receptor-dependent induction of cyp1a1 by bilirubin in mouse hepatoma hepa 1c1c7 cells .
19824022	0	Aryl_hydrocarbon	0,16	hypoxia_inducible_factor_1beta	39,69	Aryl hydrocarbon	hypoxia inducible factor 1beta	null	11863(Tax:10090)	Chemical	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Aryl_hydrocarbon nuclear translocator -LRB- hypoxia_inducible_factor_1beta -RRB- activity is required more during early than late tumor growth .
18784347	0	Aryl_hydrocarbon	0,16	sox9b	54,59	Aryl hydrocarbon	sox9b	null	60642(Tax:7955)	Chemical	Gene	down-regulation|amod|START_ENTITY down-regulation|nmod|END_ENTITY	Aryl_hydrocarbon receptor-mediated down-regulation of sox9b causes jaw_malformation in zebrafish embryos .
11243847	0	Aryl_hydrocarbon	0,16	xanthine_dehydrogenase	71,93	Aryl hydrocarbon	xanthine dehydrogenase	null	22436(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|nsubj|receptor	Aryl_hydrocarbon receptor -LRB- AhR -RRB- - mediated induction of xanthine_oxidase / xanthine_dehydrogenase activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin .
18706809	0	Aryl_sulfones	0,13	bradykinin_B1_receptor	23,45	Aryl sulfones	bradykinin B1 receptor	null	100009198(Tax:9986)	Chemical	Gene	START_ENTITY|nmod|antagonists antagonists|amod|END_ENTITY	Aryl_sulfones as novel bradykinin_B1_receptor antagonists for treatment of chronic_pain .
12954815	0	Arylacetamide	0,13	kappa-opioid_receptor	14,35	Arylacetamide	kappa-opioid receptor	null	4986	Chemical	Gene	agonists|amod|START_ENTITY agonists|amod|END_ENTITY	Arylacetamide kappa-opioid_receptor agonists produce a tonic - and use-dependent block of tetrodotoxin-sensitive and - resistant sodium currents in colon sensory neurons .
25627172	0	Arylalkenylpropargylamines	6,32	Monoamine_Oxidase_B	75,94	Arylalkenylpropargylamines	Monoamine Oxidase B	null	25750(Tax:10116)	Chemical	Gene	START_ENTITY|dep|Inhibitors Inhibitors|compound|END_ENTITY	Novel Arylalkenylpropargylamines as Neuroprotective , Potent , and Selective Monoamine_Oxidase_B Inhibitors for the Treatment of Parkinson 's _ Disease .
16829073	0	Arylamine	0,9	cathepsin_K	16,27	Arylamine	cathepsin K	CHEBI:33860	1513	Chemical	Gene	START_ENTITY|dep|inhibitors inhibitors|compound|END_ENTITY	Arylamine based cathepsin_K inhibitors : investigating P3 heterocyclic substituents .
23411075	0	Arylglycine	0,11	transient_receptor_potential_melastatin_8	34,75	Arylglycine	transient receptor potential melastatin 8	null	486170(Tax:9615)	Chemical	Gene	START_ENTITY|nmod|antagonists antagonists|amod|END_ENTITY	Arylglycine derivatives as potent transient_receptor_potential_melastatin_8 -LRB- TRPM8 -RRB- antagonists .
20709182	0	Arylhydrocarbon	0,15	AhR	26,29	Arylhydrocarbon	AhR	null	196	Chemical	Gene	activation|compound|START_ENTITY activation|appos|END_ENTITY	Arylhydrocarbon receptor -LRB- AhR -RRB- activation in airway epithelial cells induces MUC5AC via reactive oxygen species -LRB- ROS -RRB- production .
18255291	0	Arylsulfonamide	0,15	CB2	16,19	Arylsulfonamide	CB2	null	1269	Chemical	Gene	agonists|amod|START_ENTITY agonists|compound|END_ENTITY	Arylsulfonamide CB2 receptor agonists : SAR and optimization of CB2 selectivity .
24198734	0	Arzanol	0,7	mPGES-1	18,25	Arzanol	mPGES-1	MESH:C517830	64292(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Arzanol , a potent mPGES-1 inhibitor : novel anti-inflammatory agent .
11721366	0	As2O3	12,17	BCR/ABL	25,32	As2O3	BCR/ABL	CHEBI:30621	25;613	Chemical	Gene	START_ENTITY|nmod|phosphorylation phosphorylation|compound|END_ENTITY	-LSB- Effects of As2O3 on the BCR/ABL protein tyrosine phosphorylation in K562 cells -RSB- .
15634594	0	As2O3	48,53	TRAIL	61,66	As2O3	TRAIL	CHEBI:30621	22035(Tax:10090)	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Biologic changes in MDS-L cell line induced by As2O3 and/or TRAIL -RSB- .
17407144	0	Ascochlorin	0,11	MMP-9	37,42	Ascochlorin	MMP-9	MESH:C415745	4318	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Ascochlorin suppresses oxLDL-induced MMP-9 expression by inhibiting the MEK/ERK signaling pathway in human THP-1 macrophages .
21947785	0	Ascochlorin	0,11	PAI-1	38,43	Ascochlorin	PAI-1	MESH:C415745	29366(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Ascochlorin suppresses TGF-b1-induced PAI-1 expression through the inhibition of phospho-EGFR in rat kidney fibroblast cells .
17114644	0	Ascofuranone	0,12	matrix_metalloproteinase-9	37,63	Ascofuranone	matrix metalloproteinase-9	MESH:C006640	4318	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|activation activation|amod|END_ENTITY	Ascofuranone suppresses PMA-mediated matrix_metalloproteinase-9 gene activation through the Ras/Raf/MEK / ERK - and Ap1-dependent mechanisms .
16665673	0	Ascorbate	49,58	Peroxidase	59,69	Ascorbate	Peroxidase	CHEBI:38290	542029(Tax:4577)	Chemical	Gene	Activity|compound|START_ENTITY Activity|compound|END_ENTITY	Hill Reaction , Hydrogen_Peroxide Scavenging , and Ascorbate Peroxidase Activity of Mesophyll and Bundle Sheath Chloroplasts of NADP-Malic Enzyme Type C -LRB- 4 -RRB- Species .
17786340	0	Ascorbate	0,9	apoptosis-inducing_factor	53,78	Ascorbate	apoptosis-inducing factor	CHEBI:38290	9131	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Ascorbate -LRB- vitamin_C -RRB- induces cell death through the apoptosis-inducing_factor in human breast_cancer cells .
2575561	0	Ascorbate	0,9	catalase	69,77	Ascorbate	catalase	CHEBI:38290	531682(Tax:9913)	Chemical	Gene	activates|nsubj|START_ENTITY activates|nmod|END_ENTITY	Ascorbate activates soluble guanylate cyclase via H2O2-metabolism by catalase .
14556857	0	Ascorbate	0,9	iNOS	19,23	Ascorbate	iNOS	CHEBI:38290	18126(Tax:10090)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|amod|END_ENTITY	Ascorbate enhances iNOS activity by increasing tetrahydrobiopterin in RAW 264.7 cells .
1295516	0	Ascorbate	0,9	peroxidase	10,20	Ascorbate	peroxidase	CHEBI:38290	543959(Tax:4081)	Chemical	Gene	START_ENTITY|dobj|activity activity|amod|END_ENTITY	Ascorbate peroxidase activity in resistant and susceptible plants of Lycopersicon_esculentum .
25896849	0	Ascorbic_acid	0,13	HMGB1	22,27	Ascorbic acid	HMGB1	MESH:D001205	15289(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|secretion secretion|nummod|END_ENTITY	Ascorbic_acid reduces HMGB1 secretion in lipopolysaccharide-activated RAW 264.7 cells and improves survival rate in septic mice by activation of Nrf2/HO -1 signals .
25283515	0	Ascorbic_acid	46,59	LXR-a	14,19	Ascorbic acid	LXR-a	MESH:D001205	10062	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|END_ENTITY	Modulation of LXR-a and the effector genes by Ascorbic_acid and Statins in psoriatic keratinocytes .
15721175	0	Ascorbic_acid	0,13	NF-kappa_B	39,49	Ascorbic acid	NF-kappa B	MESH:D001205	447632(Tax:8355)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	Ascorbic_acid inhibits ROS production , NF-kappa_B activation and prevents ethanol-induced growth_retardation and microencephaly .
17303424	0	Ascorbic_acid	0,13	PMP22	23,28	Ascorbic acid	PMP22	MESH:D001205	18858(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Ascorbic_acid inhibits PMP22 expression by reducing cAMP levels .
19032433	0	Ascorbic_acid	0,13	catalase	15,23	Ascorbic acid	catalase	MESH:D001205	531682(Tax:9913)	Chemical	Gene	reduce|advcl|START_ENTITY reduce|nsubj|END_ENTITY	Ascorbic_acid , catalase and chlorpromazine reduce cryopreservation-induced damages to crossbred bull spermatozoa .
9054258	0	Ascorbic_acid	0,13	catechol-o-methyl_transferase	40,69	Ascorbic acid	catechol-o-methyl transferase	MESH:D001205	1312	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Ascorbic_acid inhibits spinal meningeal catechol-o-methyl_transferase in vitro , markedly increasing epinephrine bioavailability .
3711090	0	Ascorbic_acid	0,13	dopamine_beta-monooxygenase	36,63	Ascorbic acid	dopamine beta-monooxygenase	MESH:D001205	280758(Tax:9913)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|amod|END_ENTITY	Ascorbic_acid specifically enhances dopamine_beta-monooxygenase activity in resting and stimulated chromaffin cells .
11819678	0	Ascorbic_acid	0,13	gastrin	63,70	Ascorbic acid	gastrin	MESH:D001205	2520	Chemical	Gene	secretion|amod|START_ENTITY secretion|nmod|END_ENTITY	Ascorbic_acid secretion in the human stomach and the effect of gastrin .
21199573	0	Ascorbic_acid	0,13	heme_oxygenase-1	54,70	Ascorbic acid	heme oxygenase-1	MESH:D001205	3162	Chemical	Gene	antagonizes|nsubj|START_ENTITY antagonizes|dobj|END_ENTITY	Ascorbic_acid partly antagonizes resveratrol mediated heme_oxygenase-1 but not paraoxonase-1 induction in cultured hepatocytes - role of the redox-regulated transcription factor Nrf2 .
8524865	0	Ascorbic_acid	0,13	insulin	46,53	Ascorbic acid	insulin	MESH:D001205	100379579(Tax:10141)	Chemical	Gene	essential|nsubj|START_ENTITY essential|nmod|release release|nmod|END_ENTITY	Ascorbic_acid is essential for the release of insulin from scorbutic guinea_pig pancreatic islets .
21467157	0	Ascorbic_acid	0,13	osterix	24,31	Ascorbic acid	osterix	MESH:D001205	170574(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Ascorbic_acid regulates osterix expression in osteoblasts by activation of prolyl hydroxylase and ubiquitination-mediated proteosomal degradation pathway .
8869038	0	Ascorbic_acid	0,13	tropoelastin	22,34	Ascorbic acid	tropoelastin	MESH:D001205	396441(Tax:9031)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|levels levels|compound|END_ENTITY	Ascorbic_acid reduces tropoelastin levels in culture medium of chick skin fibroblasts .
21826202	0	Asiatic_acid	0,12	VEGF	48,52	Asiatic acid	VEGF	MESH:C017032	7422	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|effects effects|nmod|END_ENTITY	Asiatic_acid inhibits pro-angiogenic effects of VEGF and human gliomas in endothelial cell culture models .
23215953	0	Asn	71,74	HC1	61,64	Asn	HC1	CHEBI:17196	342358	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|appos|END_ENTITY	Erythrocytosis in a child due to Hb Andrew-Minneapolis -LSB- b144 -LRB- HC1 -RRB- Lys _ > _ Asn -LRB- AAG > AAT or AAC -RRB- -RSB- associated with a Spanish -LRB- b -RRB- -LRB- 0 -RRB- - thalassemia .
22157018	3	Asn	400,403	ODC	414,417	Asn	AZ1	CHEBI:17196	4946	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Thus , the mechanism by which Asn activates ODC is important for understanding the regulation of ODC activity .
1652889	0	Asn	65,68	gelsolin	81,89	Asn	gelsolin	CHEBI:17196	2934	Chemical	Gene	mutation|compound|START_ENTITY mutation|nmod|END_ENTITY	Finnish type of familial_amyloidosis : cosegregation of Asp187 -- Asn mutation of gelsolin with the disease in three large families .
8406453	0	Asp	23,26	ALPL	39,43	Asp	ALPL	CHEBI:22660	249	Chemical	Gene	mutation|compound|START_ENTITY mutation|nmod|END_ENTITY	A homoallelic Gly317 -- > Asp mutation in ALPL causes the perinatal -LRB- lethal -RRB- form of hypophosphatasia in Canadian mennonites .
15140628	0	Asp	66,69	B2_receptor	92,103	Asp	B2 receptor	CHEBI:22660	624	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	The N-terminal of icatibant and bradykinin interact with the same Asp residues in the human B2_receptor .
14977832	0	Asp	31,34	FLT3	26,30	Asp	FLT3	CHEBI:22660	2322	Chemical	Gene	mutations|compound|START_ENTITY mutations|compound|END_ENTITY	Heterogeneous patterns of FLT3 Asp -LRB- 835 -RRB- mutations in relapsed de novo acute_myeloid_leukemia : a comparative analysis of 120 paired diagnostic and relapse bone marrow samples .
18752451	0	Asp	11,14	TGFBI	47,52	Asp	TGFBI	CHEBI:22660	7045	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	p.Ala546 _ > _ Asp and p.Arg555 _ > _ Trp mutations of TGFBI gene and their clinical manifestations in two large Chinese families with granular_corneal_dystrophy_type_I .
17909004	0	Asp	95,98	UGT2B10	77,84	Asp	UGT2B10	CHEBI:22660	7365	Chemical	Gene	polymorphism|compound|START_ENTITY polymorphism|amod|END_ENTITY	Glucuronidation of nicotine and cotinine by UGT2B10 : loss of function by the UGT2B10 Codon 67 -LRB- Asp > Tyr -RRB- polymorphism .
9622496	0	Asp	38,41	medium-chain_acyl-CoA_dehydrogenase	54,89	Asp	medium-chain acyl-CoA dehydrogenase	CHEBI:22660	34	Chemical	Gene	mutation|compound|START_ENTITY mutation|nmod|END_ENTITY	Discriminatory influence of Glu-376 -- > Asp mutation in medium-chain_acyl-CoA_dehydrogenase on the binding of selected CoA-ligands : spectroscopic , thermodynamic , kinetic , and model building studies .
19005973	0	Asp	4,7	sex_hormone-binding_globulin	36,64	Asp	sex hormone-binding globulin	CHEBI:22660	6462	Chemical	Gene	polymorphism|compound|START_ENTITY polymorphism|nmod|gene gene|amod|END_ENTITY	The Asp -LRB- 327 -RRB- Asn polymorphism in the sex_hormone-binding_globulin gene modifies the association of soy food and tea intake with endometrial_cancer risk .
7954361	0	Asparagine	0,10	ornithine_decarboxylase	46,69	Asparagine	ornithine decarboxylase	CHEBI:17196	4953	Chemical	Gene	markedly|compound|START_ENTITY induces|nsubj|markedly induces|dobj|expression expression|nmod|gene gene|amod|END_ENTITY	Asparagine markedly induces the expression of ornithine_decarboxylase gene in transformed mammalian cells but not in their untransformed counterparts .
22853297	0	Aspartame	0,9	insulin	51,58	Aspartame	insulin	MESH:D001218	3630	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|levels levels|compound|END_ENTITY	Aspartame in conjunction with carbohydrate reduces insulin levels during endurance exercise .
2923074	0	Aspartame	0,9	prolactin	54,63	Aspartame	prolactin	MESH:D001218	5617	Chemical	Gene	START_ENTITY|dep|effects effects|nmod|END_ENTITY	Aspartame and its constituent amino_acids : effects on prolactin , cortisol , growth_hormone , insulin , and glucose in normal humans .
9341147	0	Aspartate	0,9	growth_hormone	65,79	Aspartate	growth hormone	CHEBI:29995	2688	Chemical	Gene	171|compound|START_ENTITY determinant|nsubj|171 determinant|nmod|END_ENTITY	Aspartate 171 is the major primate-specific determinant of human growth_hormone .
22382901	0	Aspartic_acid	0,13	monoamine_oxidase-A	31,50	Aspartic acid	monoamine oxidase-A	CHEBI:22660	4128	Chemical	Gene	substitutions|amod|START_ENTITY substitutions|nmod|END_ENTITY	Aspartic_acid substitutions in monoamine_oxidase-A reveal both catalytic-dependent and - independent influences on cell viability and proliferation .
2441481	0	Asperlicin	0,10	cholecystokinin	32,47	Asperlicin	cholecystokinin	MESH:C046367	100735029	Chemical	Gene	START_ENTITY|dep|antagonist antagonist|compound|END_ENTITY	Asperlicin : a unique nonpeptide cholecystokinin antagonist .
21452371	0	Asperosaponin_VI	0,16	bone_morphogenetic_protein-2	107,135	Asperosaponin VI	bone morphogenetic protein-2	MESH:C534004	12156(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Asperosaponin_VI , a saponin component from Dipsacus asper wall , induces osteoblast differentiation through bone_morphogenetic_protein-2 / p38 and extracellular_signal-regulated_kinase_1 / 2 pathway .
12368230	0	Aspirin	0,7	5-lipoxygenase	24,38	Aspirin	5-lipoxygenase	MESH:D001241	25290(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	Aspirin -LRB- ASA -RRB- regulates 5-lipoxygenase activity and peroxisome_proliferator-activated_receptor_alpha-mediated CINC-1 release in rat liver cells : novel actions of lipoxin A4 -LRB- LXA4 -RRB- and ASA-triggered_15-epi-LXA4 .
11849193	10	Aspirin	1461,1468	ACE	1588,1591	Aspirin	ACE	MESH:D001241	1636	Chemical	Gene	treated|nsubj|START_ENTITY treated|nmod|inhibitor inhibitor|compound|END_ENTITY	CONCLUSIONS : Aspirin has no effect on the vasodilator response to bradykinin and substance_P in patients with heart_failure treated with an ACE inhibitor .
19522741	0	Aspirin	0,7	C-reactive_protein	46,64	Aspirin	C-reactive protein	MESH:D001241	12944(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|activity activity|nmod|END_ENTITY	Aspirin reduces the prothrombotic activity of C-reactive_protein .
23778008	0	Aspirin	0,7	C-reactive_protein	88,106	Aspirin	C-reactive protein	MESH:D001241	1401	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|nmod|level level|amod|END_ENTITY	Aspirin possibly reduces cerebrovascular events in type 2 diabetic patients with higher C-reactive_protein level : subanalysis from the JPAD trial .
24155779	0	Aspirin	0,7	COX-1	50,55	Aspirin	COX-1	MESH:D001241	4512	Chemical	Gene	Viability|compound|START_ENTITY Viability|nmod|Manner Manner|compound|END_ENTITY	Aspirin Blocks EGF-stimulated Cell Viability in a COX-1 Dependent Manner in Ovarian_Cancer Cells .
26517138	0	Aspirin	123,130	COX-1	40,45	Aspirin	COX-1	MESH:D001241	5742	Chemical	Gene	Treated|nmod|START_ENTITY Implication|acl|Treated Implication|nmod|END_ENTITY	The Implication of the Polymorphisms of COX-1 , UGT1A6 , and CYP2C9 among Cardiovascular_Disease -LRB- CVD -RRB- Patients Treated with Aspirin .
14665439	0	Aspirin	0,7	COX-2	75,80	Aspirin	COX-2	MESH:D001241	26198(Tax:10116)	Chemical	Gene	interacts|nsubj|START_ENTITY interacts|nmod|inhibitors inhibitors|compound|END_ENTITY	Aspirin , but not NO-releasing aspirin -LRB- NCX-4016 -RRB- , interacts with selective COX-2 inhibitors to aggravate gastric_damage and inflammation .
15756426	0	Aspirin	0,7	COX-2	125,130	Aspirin	COX-2	MESH:D001241	5743	Chemical	Gene	START_ENTITY|dep|review review|nmod|blockade blockade|compound|END_ENTITY	Aspirin , ibuprofen , and other non-steroidal anti-inflammatory drugs in cancer prevention : a critical review of non-selective COX-2 blockade -LRB- review -RRB- .
21331307	0	Aspirin	50,57	COX-2	0,5	Aspirin	COX-2	MESH:D001241	5743	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|compound|END_ENTITY	COX-2 Inhibition by Use of Rofecoxib or High Dose Aspirin Enhances ADP-Induced Platelet Aggregation in Fresh Blood .
24209633	0	Aspirin	0,7	COX-2	44,49	Aspirin	COX-2	MESH:D001241	4513	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Aspirin inhibits lipopolysaccharide-induced COX-2 expression and PGE2 production in porcine alveolar macrophages by modulating protein kinase C and protein tyrosine phosphatase activity .
26685215	0	Aspirin	39,46	Cyclin_A2	0,9	Aspirin	Cyclin A2	MESH:D001241	890	Chemical	Gene	Targets|nmod|START_ENTITY END_ENTITY|nmod|Targets	Cyclin_A2 and CDK2 as Novel Targets of Aspirin and Salicylic_acid : a Potential Role in Cancer Prevention .
19424877	0	Aspirin	0,7	ErbB2	17,22	Aspirin	ErbB2	MESH:D001241	2064	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Aspirin inhibits ErbB2 to induce apoptosis in cervical_cancer cells .
15240146	0	Aspirin	0,7	IRS-1	43,48	Aspirin	IRS-1	MESH:D001241	25467(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Aspirin inhibits serine phosphorylation of IRS-1 in muscle and adipose tissue of septic rats .
15485683	0	Aspirin	0,7	LOX-1	33,38	Aspirin	LOX-1	MESH:D001241	4973	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Aspirin inhibits ox-LDL-mediated LOX-1 expression and metalloproteinase-1 in human coronary endothelial cells .
18971601	0	Aspirin	0,7	MMP-2	17,22	Aspirin	MMP-2	MESH:D001241	4313	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expressions expressions|amod|END_ENTITY	Aspirin inhibits MMP-2 and MMP-9 expressions and activities through upregulation of PPARalpha/gamma and TIMP gene expressions in ox-LDL-stimulated macrophages derived from human monocytes .
19462226	0	Aspirin	0,7	MMP-2	17,22	Aspirin	MMP-2	MESH:D001241	17390(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Aspirin inhibits MMP-2 and MMP-9 expression and activity through PPARalpha/gamma and TIMP-1-mediated mechanisms in cultured mouse celiac macrophages .
15036249	0	Aspirin	0,7	NF-kappaB	44,53	Aspirin	NF-kappaB	MESH:D001241	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	Aspirin inhibits TNFalpha - and IL-1-induced NF-kappaB activation and sensitizes HeLa cells to apoptosis .
15987633	0	Aspirin	0,7	NF-kappaB	17,26	Aspirin	NF-kappaB	MESH:D001241	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	Aspirin inhibits NF-kappaB activation in a glycolysis-depleted lung epithelial cell line .
16336399	0	Aspirin	0,7	NF-kappaB	83,92	Aspirin	NF-kappaB	MESH:D001241	4790	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|inhibiting inhibiting|dobj|pathway pathway|nmod|regulation regulation|amod|END_ENTITY	Aspirin induces apoptosis in oesophageal_cancer cells by inhibiting the pathway of NF-kappaB downstream regulation of cyclooxygenase-2 .
17132819	0	Aspirin	0,7	NF-kappaB	22,31	Aspirin	NF-kappaB	MESH:D001241	4790	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|pathway pathway|amod|END_ENTITY	Aspirin activates the NF-kappaB signalling pathway and induces apoptosis in intestinal neoplasia in two in vivo models of human colorectal_cancer .
19936928	0	Aspirin	0,7	NF-kappaB	67,76	Aspirin	NF-kappaB	MESH:D001241	4790	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|apoptosis apoptosis|nmod|cells cells|nmod|END_ENTITY	Aspirin induces apoptosis in human leukemia cells independently of NF-kappaB and MAPKs through alteration of the Mcl-1 / Noxa balance .
12721317	0	Aspirin	0,7	NF-kappa_B	46,56	Aspirin	NF-kappa B	MESH:D001241	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	Aspirin inhibits Chlamydia_pneumoniae-induced NF-kappa_B activation , cyclo-oxygenase-2 expression and prostaglandin_E2 synthesis and attenuates chlamydial growth .
26810856	0	Aspirin	0,7	Slug	174,178	Aspirin	Slug	MESH:D001241	6591	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Aspirin inhibits epithelial-to-mesenchymal transition and migration of oncogenic K-ras-expressing non-small_cell_lung_carcinoma cells by down-regulating E-cadherin repressor Slug .
15036249	0	Aspirin	0,7	TNFalpha	17,25	Aspirin	TNFalpha	MESH:D001241	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	Aspirin inhibits TNFalpha - and IL-1-induced NF-kappaB activation and sensitizes HeLa cells to apoptosis .
10362194	0	Aspirin	0,7	angiotensin-converting_enzyme	47,76	Aspirin	angiotensin-converting enzyme	MESH:D001241	1636	Chemical	Gene	START_ENTITY|nmod|patients patients|acl|treated treated|nmod|inhibitors inhibitors|amod|END_ENTITY	Aspirin and mortality in patients treated with angiotensin-converting_enzyme inhibitors : a cohort study of 11,575 patients with coronary_artery_disease .
10426836	0	Aspirin	0,7	angiotensin-converting_enzyme	110,139	Aspirin	angiotensin-converting enzyme	MESH:D001241	1636	Chemical	Gene	worsens|compound|START_ENTITY exercise|nsubj|worsens exercise|dobj|exchange exchange|acl:relcl|taking taking|dobj|inhibitors inhibitors|amod|END_ENTITY	Aspirin worsens exercise performance and pulmonary gas exchange in patients with heart_failure who are taking angiotensin-converting_enzyme inhibitors .
11246058	0	Aspirin	0,7	angiotensin-converting_enzyme	41,70	Aspirin	angiotensin-converting enzyme	MESH:D001241	1636	Chemical	Gene	influence|nsubj|START_ENTITY influence|dobj|effect effect|nmod|inhibition inhibition|amod|END_ENTITY	Aspirin does not influence the effect of angiotensin-converting_enzyme inhibition on left ventricular ejection fraction 3 months after acute_myocardial_infarction .
18355801	0	Aspirin	0,7	bradykinin	23,33	Aspirin	bradykinin	MESH:D001241	3827	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|ccomp|ligand ligand|nsubj|B2_receptor B2_receptor|compound|END_ENTITY	Aspirin inhibits human bradykinin B2_receptor ligand binding function .
26314861	0	Aspirin	0,7	c-Myc	36,41	Aspirin	c-Myc	MESH:D001241	4609	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Aspirin and salicylic_acid decrease c-Myc expression in cancer cells : a potential role in chemoprevention .
9660772	0	Aspirin	0,7	cytochrome_P450	48,63	Aspirin	cytochrome P450	MESH:D001241	4051	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	Aspirin inhibition and acetylation of the plant cytochrome_P450 , allene_oxide_synthase , resembles that of animal prostaglandin_endoperoxide H synthase .
19493461	0	Aspirin	0,7	fractalkine	56,67	Aspirin	fractalkine	MESH:D001241	6376	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Aspirin inhibits tumor_necrosis_factor-alpha-stimulated fractalkine expression in human umbilical vein endothelial cells .
12714600	0	Aspirin	0,7	insulin_receptor_substrate_1	43,71	Aspirin	insulin receptor substrate 1	MESH:D001241	3667	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Aspirin inhibits serine phosphorylation of insulin_receptor_substrate_1 in tumor_necrosis_factor-treated cells through targeting multiple serine kinases .
15922338	0	Aspirin	0,7	insulin_receptor_substrate_1	43,71	Aspirin	insulin receptor substrate 1	MESH:D001241	25467(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Aspirin inhibits serine phosphorylation of insulin_receptor_substrate_1 in growth hormone treated animals .
22406476	0	Aspirin	0,7	mTOR	17,21	Aspirin	mTOR	MESH:D001241	21977(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Aspirin inhibits mTOR signaling , activates AMP-activated protein kinase , and induces autophagy in colorectal_cancer cells .
15136050	0	Aspirin	0,7	monocyte_chemoattractant_protein-1	17,51	Aspirin	monocyte chemoattractant protein-1	MESH:D001241	6347	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Aspirin inhibits monocyte_chemoattractant_protein-1 and interleukin-8 expression in TNF-alpha stimulated human umbilical vein endothelial cells .
16600694	0	Aspirin	0,7	monocyte_chemoattractant_protein-1	42,76	Aspirin	monocyte chemoattractant protein-1	MESH:D001241	6347	Chemical	Gene	activators|compound|START_ENTITY inhibit|nsubj|activators inhibit|dobj|expression expression|amod|END_ENTITY	Aspirin and PPAR-alpha activators inhibit monocyte_chemoattractant_protein-1 expression induced by high glucose concentration in human endothelial cells .
16943621	0	Aspirin	0,7	ribonuclease_A	25,39	Aspirin	ribonuclease A	MESH:D001241	6035	Chemical	Gene	interaction|nsubj|START_ENTITY interaction|nmod|END_ENTITY	Aspirin interaction with ribonuclease_A .
12943528	0	Aspirin	0,7	vascular_endothelial_growth_factor	69,103	Aspirin	vascular endothelial growth factor	MESH:D001241	83785(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|parataxis|END_ENTITY	Aspirin inhibits endothelial nitric_oxide synthase -LRB- eNOS -RRB- and Flk-1 -LRB- vascular_endothelial_growth_factor receptor-2 -RRB- prior to rat colon_tumour development .
14996470	0	Aspirin	0,7	vascular_endothelial_growth_factor	18,52	Aspirin	vascular endothelial growth factor	MESH:D001241	7422	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|release release|compound|END_ENTITY	Aspirin decreases vascular_endothelial_growth_factor release during myocardial_ischemia .
26327350	0	Asporin	0,7	TGF-b1	32,38	Asporin	TGF-b1	null	7040	Chemical	Gene	Inhibitor|nsubj|START_ENTITY Inhibitor|compound|END_ENTITY	Asporin Is a Fibroblast-Derived TGF-b1 Inhibitor and a Tumor Suppressor Associated with Good Prognosis in Breast_Cancer .
26921637	0	Astaxanthin	0,11	Rad51	27,32	Astaxanthin	Rad51	MESH:C005948	5888	Chemical	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Astaxanthin down-regulates Rad51 expression via inactivation of AKT kinase to enhance mitomycin_C-induced cytotoxicity in human non-small_cell_lung_cancer cells .
20828541	0	Astaxanthin	0,11	heme_oxygenase-1	24,40	Astaxanthin	heme oxygenase-1	MESH:C005948	3162	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Astaxanthin upregulates heme_oxygenase-1 expression through ERK1/2 pathway and its protective effect against beta-amyloid-induced cytotoxicity in SH-SY5Y cells .
25069610	0	Astragalin	0,10	eotaxin-1	27,36	Astragalin	eotaxin-1	MESH:C001579	6356	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|induction induction|amod|END_ENTITY	Astragalin inhibits airway eotaxin-1 induction and epithelial apoptosis through modulating oxidative stress-responsive MAPK signaling .
24676670	0	Astragaloside	0,13	P-glycoprotein	50,64	Astragaloside	P-glycoprotein	null	5243	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|level level|nmod|END_ENTITY	Astragaloside reduces the expression level of P-glycoprotein in multidrug-resistant human hepatic_cancer cell lines .
26261569	0	Astragaloside	0,13	SMAD2/3	32,39	Astragaloside	SMAD2/3	null	17126;17127	Chemical	Gene	effect|amod|START_ENTITY effect|nmod|END_ENTITY	Astragaloside effect on TGF-b1 , SMAD2/3 , and a-SMA expression in the kidney tissues of diabetic KKAy mice .
27023226	0	Astragaloside_IV	0,16	BACE1	110,115	Astragaloside IV	BACE1	MESH:C052064	23821(Tax:10090)	Chemical	Gene	Reduces|nsubj|START_ENTITY Reduces|nmod|Inhibition Inhibition|nmod|END_ENTITY	Astragaloside_IV , a Natural PPARy Agonist , Reduces Ab Production in Alzheimer 's _ Disease Through Inhibition of BACE1 .
26074989	0	Astragaloside_IV	11,27	SDF-1	35,40	Astragaloside IV	SDF-1	MESH:C052064	20315(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of Astragaloside_IV on the SDF-1 / CXCR4 Expression in Atherosclerosis of apoE -LRB- - / - -RRB- Mice Induced by Hyperlipaemia .
23041150	0	Astragaloside_IV	0,16	Toll-like_receptor_4	28,48	Astragaloside IV	Toll-like receptor 4	MESH:C052064	7099	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|compound|END_ENTITY	Astragaloside_IV attenuates Toll-like_receptor_4 expression via NF-kB pathway under high glucose condition in mesenchymal stem cells .
26750705	0	Astragaloside_IV	0,16	glucocorticoid_receptor	51,74	Astragaloside IV	glucocorticoid receptor	MESH:C052064	2908	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	Astragaloside_IV inhibits microglia activation via glucocorticoid_receptor mediated signaling pathway .
9030428	0	Astressin	0,9	CRF	30,33	Astressin	CRF	MESH:C104416	1392	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Astressin , a novel and potent CRF antagonist , is neuroprotective in the hippocampus when administered after a seizure .
9118346	0	Astressin	15,24	CRH	82,85	Astressin	CRH	MESH:C104416	1392	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|antagonist antagonist|appos|END_ENTITY	The effect of ` Astressin ' , a novel antagonist of corticotropin_releasing_hormone -LRB- CRH -RRB- , on CRH-induced seizures in the infant rat : comparison with two other antagonists .
9118346	0	Astressin	15,24	corticotropin_releasing_hormone	49,80	Astressin	corticotropin releasing hormone	MESH:C104416	1392	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|antagonist antagonist|nmod|END_ENTITY	The effect of ` Astressin ' , a novel antagonist of corticotropin_releasing_hormone -LRB- CRH -RRB- , on CRH-induced seizures in the infant rat : comparison with two other antagonists .
26959555	0	Asymmetric_Dimethylarginine	0,27	Akt1	39,43	Asymmetric Dimethylarginine	Akt1	CHEBI:17929	207	Chemical	Gene	Phosphorylation|compound|START_ENTITY Phosphorylation|compound|END_ENTITY	Asymmetric_Dimethylarginine Stimulates Akt1 Phosphorylation via Hsp70-facilitated CTMP Degradation in Pulmonary Arterial Endothelial Cells .
26403849	0	Asymmetric_dimethylarginine	0,27	SLC25A2	72,79	Asymmetric dimethylarginine	SLC25A2	CHEBI:17929	83884	Chemical	Gene	transported|nsubjpass|START_ENTITY transported|nmod|END_ENTITY	Asymmetric_dimethylarginine is transported by the mitochondrial carrier SLC25A2 .
2104629	0	Atenolol	0,8	growth_hormone	28,42	Atenolol	growth hormone	MESH:D001262	2688	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|ccomp|release release|nsubj|END_ENTITY	Atenolol enhances nocturnal growth_hormone -LRB- GH -RRB- release in GH-deficient children during long term GH-releasing_hormone therapy .
3131726	0	Atenolol	0,8	growth_hormone	18,32	Atenolol	growth hormone	MESH:D001262	2688	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|release release|amod|END_ENTITY	Atenolol enhances growth_hormone release to exogenous growth_hormone-releasing hormone but fails to alter spontaneous nocturnal growth_hormone secretion in boys with constitutional delay of growth .
26447643	0	Atomoxetine	52,63	Dopamine_Beta_Hydroxylase	12,37	Atomoxetine	Dopamine Beta Hydroxylase	MESH:C041930	1621	Chemical	Gene	Response|compound|START_ENTITY Response|compound|END_ENTITY	Variants of Dopamine_Beta_Hydroxylase Gene Moderate Atomoxetine Response in Children with Attention-Deficit/Hyperactivity _ Disorder .
16896954	0	Atomoxetine	0,11	norepinephrine_transporter	25,51	Atomoxetine	norepinephrine transporter	MESH:C041930	6530	Chemical	Gene	occupies|nsubj|START_ENTITY occupies|dobj|END_ENTITY	Atomoxetine occupies the norepinephrine_transporter in a dose-dependent fashion : a PET study in nonhuman primate brain using -LRB- S , S -RRB- - -LSB- 18F -RSB- FMeNER-D2 .
18427282	0	Atorvastatin	0,12	ABCA1	22,27	Atorvastatin	ABCA1	MESH:C065179	19	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Atorvastatin inhibits ABCA1 expression and cholesterol efflux in THP-1 macrophages by an LXR-dependent pathway .
24007717	0	Atorvastatin	0,12	ABCA1	57,62	Atorvastatin	ABCA1	MESH:C065179	19	Chemical	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Atorvastatin and hormone_therapy influence expression of ABCA1 , APOA1 and SCARB1 in mononuclear cells from hypercholesterolemic postmenopausal women .
22094353	0	Atorvastatin	0,12	APOE	44,48	Atorvastatin	APOE	MESH:C065179	348	Chemical	Gene	effects|compound|START_ENTITY effects|nmod|expression expression|amod|END_ENTITY	Atorvastatin and hormone therapy effects on APOE mRNA expression in hypercholesterolemic postmenopausal women .
25860945	0	Atorvastatin	41,53	APOE	0,4	Atorvastatin	APOE	MESH:C065179	348	Chemical	Gene	Response|compound|START_ENTITY Reduced|dobj|Response Contribute|xcomp|Reduced Contribute|nsubj|Polymorphisms Polymorphisms|compound|END_ENTITY	APOE Polymorphisms Contribute to Reduced Atorvastatin Response in Chilean Amerindian Subjects .
26089622	0	Atorvastatin	161,173	Angiotensin-II	88,102	Atorvastatin	Angiotensin-II	MESH:C065179	183	Chemical	Gene	Combination|compound|START_ENTITY Interaction|nmod|Combination Application|nmod|Interaction Development|dep|Application Development|nmod|Spectrometry Spectrometry|nmod|END_ENTITY	Method Development and Validation of Liquid Chromatography-Tandem Mass Spectrometry for Angiotensin-II in Human Plasma : Application to Study Interaction Between Atorvastatin _ Olmesartan Drug Combination .
21130458	0	Atorvastatin	0,12	ApoE	79,83	Atorvastatin	ApoE	MESH:C065179	11816(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|independent independent|nsubj|development development|nmod|mice mice|compound|END_ENTITY	Atorvastatin inhibits plaque development and adventitial neovascularization in ApoE deficient mice independent of plasma cholesterol levels .
23615158	0	Atorvastatin	0,12	ApoE	128,132	Atorvastatin	ApoE	MESH:C065179	11816(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|alleviate alleviate|nmod|mice mice|compound|END_ENTITY	Atorvastatin inhibits the 5-lipoxygenase pathway and expression of CCL3 to alleviate atherosclerotic_lesions in atherosclerotic ApoE knockout mice .
18441463	0	Atorvastatin	0,12	BMP-2	27,32	Atorvastatin	BMP-2	MESH:C065179	650	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|compound|END_ENTITY	Atorvastatin downregulates BMP-2 expression induced by oxidized low-density lipoprotein in human umbilical vein endothelial cells .
26229958	0	Atorvastatin	0,12	C-Reactive_Protein	78,96	Atorvastatin	C-Reactive Protein	MESH:C065179	1401	Chemical	Gene	Treatment|compound|START_ENTITY Treatment|nmod|END_ENTITY	Atorvastatin Treatment for Atrial_Fibrillation Reduces Serum High-Sensitivity C-Reactive_Protein Levels .
26566148	0	Atorvastatin	11,23	C-Reactive_Protein	48,66	Atorvastatin	C-Reactive Protein	MESH:C065179	1401	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of Atorvastatin on Serum High-Sensitive C-Reactive_Protein and Total Cholesterol Levels in Asian Patients With Atrial_Fibrillation .
11836286	0	Atorvastatin	0,12	C-reactive_protein	20,38	Atorvastatin	C-reactive protein	MESH:C065179	1401	Chemical	Gene	lowers|nsubj|START_ENTITY lowers|dobj|END_ENTITY	Atorvastatin lowers C-reactive_protein and improves endothelium-dependent vasodilation in type_2_diabetes_mellitus .
12768071	0	Atorvastatin	0,12	C-reactive_protein	83,101	Atorvastatin	C-reactive protein	MESH:C065179	1401	Chemical	Gene	START_ENTITY|dep|effects effects|nmod|lipoproteins lipoproteins|appos|END_ENTITY	Atorvastatin and simvastatin in patients on hemodialysis : effects on lipoproteins , C-reactive_protein and in vivo oxidized LDL .
12803732	0	Atorvastatin	0,12	C-reactive_protein	21,39	Atorvastatin	C-reactive protein	MESH:C065179	1401	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|levels levels|amod|END_ENTITY	Atorvastatin affects C-reactive_protein levels in patients with coronary_artery_disease .
15535926	0	Atorvastatin	1,13	C-reactive_protein	21,39	Atorvastatin	C-reactive protein	MESH:C065179	1401	Chemical	Gene	lowers|nsubj|START_ENTITY lowers|dobj|END_ENTITY	-LSB- Atorvastatin lowers C-reactive_protein in dislipemic patients with type_2_diabetes_mellitus -RSB- .
18573823	0	Atorvastatin	0,12	C-reactive_protein	40,58	Atorvastatin	C-reactive protein	MESH:C065179	1401	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|END_ENTITY	Atorvastatin decreases high-sensitivity C-reactive_protein in multiple_sclerosis .
21584495	0	Atorvastatin	0,12	C-reactive_protein	62,80	Atorvastatin	C-reactive protein	MESH:C065179	1401	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|nmod|END_ENTITY	Atorvastatin reduces lipopolysaccharide-induced expression of C-reactive_protein in human lung epithelial cells .
25899452	0	Atorvastatin	151,163	C-reactive_protein	26,44	Atorvastatin	C-reactive protein	MESH:C065179	1401	Chemical	Gene	Trial|compound|START_ENTITY analyses|nmod|Trial Effect|dep|analyses Effect|nmod|atorvastatin atorvastatin|nmod|END_ENTITY	Effect of atorvastatin on C-reactive_protein and benefits for cardiovascular_disease in patients with type 2 diabetes : analyses from the Collaborative Atorvastatin Diabetes Trial .
15110783	0	Atorvastatin	0,12	CD68	21,25	Atorvastatin	CD68	MESH:C065179	968	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|iobj|END_ENTITY	Atorvastatin reduces CD68 , FABP4 , and HBP expression in oxLDL-treated human macrophages .
25283087	0	Atorvastatin	0,12	CD68	22,26	Atorvastatin	CD68	MESH:C065179	968	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Atorvastatin Inhibits CD68 Expression in Aortic Root Through a GRP78-Involved Pathway .
14531725	17	Atorvastatin	2073,2085	CYP3A4	2114,2120	Atorvastatin	OATP C	MESH:C065179	10599	Chemical	Gene	subject|nsubj|START_ENTITY subject|xcomp|metabolism metabolism|nmod|END_ENTITY	Atorvastatin is subject to metabolism by CYP3A4 and cellular membrane transport by OATP_C and P-glycoprotein , and drug-drug interactions with potent inhibitors of these systems , such as itraconazole , nelfinavir , ritonavir , cyclosporin , fibrates , erythromycin and grapefruit juice , have been demonstrated .
19556713	0	Atorvastatin	0,12	Endoglin	23,31	Atorvastatin	Endoglin	MESH:C065179	13805(Tax:10090)	Chemical	Gene	SMAD2/3|compound|START_ENTITY SMAD2/3|compound|END_ENTITY	Atorvastatin Increases Endoglin , SMAD2 , Phosphorylated SMAD2/3 and eNOS Expression in ApoE/LDLR Double Knockout Mice .
18036354	0	Atorvastatin	0,12	GSK-3beta	22,31	Atorvastatin	GSK-3beta	MESH:C065179	84027(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Atorvastatin inhibits GSK-3beta phosphorylation by cardiac hypertrophic_stimuli .
26616597	0	Atorvastatin	10,22	Growth_Differentiation_Factor-15	26,58	Atorvastatin	Growth Differentiation Factor-15	MESH:C065179	9518	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of Atorvastatin on Growth_Differentiation_Factor-15 in Patients with Type_2_Diabetes_Mellitus and Dyslipidemia .
9469588	0	Atorvastatin	0,12	HMG-CoA_reductase	60,77	Atorvastatin	HMG-CoA reductase	MESH:C065179	25675(Tax:10116)	Chemical	Gene	action|compound|START_ENTITY involves|nsubj|action involves|dobj|recovery recovery|nmod|activity activity|amod|END_ENTITY	Atorvastatin action involves diminished recovery of hepatic HMG-CoA_reductase activity .
23226786	0	Atorvastatin	0,12	HMGB1	27,32	Atorvastatin	HMGB1	MESH:C065179	3146	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|levels levels|compound|END_ENTITY	Atorvastatin reduces serum HMGB1 levels in patients with hyperlipidemia .
25341814	0	Atorvastatin	0,12	Heme_Oxygenase-1	49,65	Atorvastatin	Heme Oxygenase-1	MESH:C065179	3162	Chemical	Gene	Production|compound|START_ENTITY Production|nmod|Pathway Pathway|compound|END_ENTITY	Atorvastatin Attenuates TNF-alpha Production via Heme_Oxygenase-1 Pathway in LPS-stimulated RAW264 .7 Macrophages .
14637261	0	Atorvastatin	0,12	MCP-1	28,33	Atorvastatin	MCP-1	MESH:C065179	6347	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	Atorvastatin reduces plasma MCP-1 in patients with acute_coronary_syndrome .
22814256	0	Atorvastatin	0,12	MMP-9	75,80	Atorvastatin	MMP-9	MESH:C065179	17395(Tax:10090)	Chemical	Gene	up-regulate|nsubj|START_ENTITY up-regulate|dobj|expression expression|compound|END_ENTITY	Atorvastatin and simvastatin , but not pravastatin , up-regulate LPS-induced MMP-9 expression in macrophages by regulating phosphorylation of ERK and CREB .
21123766	0	Atorvastatin	0,12	NPC1L1	48,54	Atorvastatin	NPC1L1	MESH:C065179	29881	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Atorvastatin increases intestinal expression of NPC1L1 in hyperlipidemic men .
18649055	0	Atorvastatin	0,12	P-selectin	55,65	Atorvastatin	P-selectin	MESH:C065179	6403	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|reductions reductions|nmod|END_ENTITY	Atorvastatin induces associated reductions in platelet P-selectin , oxidized low-density lipoprotein , and interleukin-6 in patients with coronary_artery_diseases .
21614411	0	Atorvastatin	0,12	P-selectin	74,84	Atorvastatin	P-selectin	MESH:C065179	6403	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	Atorvastatin reduces thrombin generation and expression of tissue factor , P-selectin and GPIIIa on platelet-derived microparticles in patients with peripheral arterial_occlusive_disease .
11926313	0	Atorvastatin	0,12	PPAR-gamma	23,33	Atorvastatin	PPAR-gamma	MESH:C065179	5468	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Atorvastatin activates PPAR-gamma and attenuates the inflammatory response in human monocytes .
15912134	0	Atorvastatin	0,12	PPARalpha	59,68	Atorvastatin	PPARalpha	MESH:C065179	25747(Tax:10116)	Chemical	Gene	reverses|nsubj|START_ENTITY reverses|nmod|END_ENTITY	Atorvastatin reverses age-related reduction in rat hepatic PPARalpha and HNF-4 .
25279006	0	Atorvastatin	0,12	RAGE	40,44	Atorvastatin	RAGE	MESH:C065179	81722(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Atorvastatin inhibits the expression of RAGE induced by advanced glycation end products on aortas in healthy Sprague-Dawley_rats .
20553382	0	Atorvastatin	0,12	TFPI	41,45	Atorvastatin	TFPI	MESH:C065179	100155068(Tax:9823)	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Atorvastatin or transgenic expression of TFPI inhibits coagulation initiated by anti-nonGal IgG binding to porcine aortic endothelial cells .
22178874	0	Atorvastatin	0,12	TLR2	62,66	Atorvastatin	TLR2	MESH:C065179	7097	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Atorvastatin inhibits functional expression of proatherogenic TLR2 in arterial endothelial cells .
25341814	0	Atorvastatin	0,12	TNF-alpha	24,33	Atorvastatin	TNF-alpha	MESH:C065179	7124	Chemical	Gene	Production|compound|START_ENTITY Production|compound|END_ENTITY	Atorvastatin Attenuates TNF-alpha Production via Heme_Oxygenase-1 Pathway in LPS-stimulated RAW264 .7 Macrophages .
26574625	0	Atorvastatin	0,12	TNF-alpha	42,51	Atorvastatin	TNF-alpha	MESH:C065179	7124	Chemical	Gene	reduced|nsubj|START_ENTITY reduced|dobj|receptors receptors|nmod|END_ENTITY	Atorvastatin reduced soluble receptors of TNF-alpha in systemic_lupus_erythematosus .
26885117	0	Atorvastatin	0,12	TRIB3	26,31	Atorvastatin	TRIB3	MESH:C065179	57761	Chemical	Gene	up-regulates|compound|START_ENTITY END_ENTITY|nsubj|up-regulates	Atorvastatin up-regulates TRIB3 independent of ATF4-CHOP pathway in atherosclerotic patients .
21317307	0	Atorvastatin	0,12	Toll-like_receptor_4	58,78	Atorvastatin	Toll-like receptor 4	MESH:C065179	7099	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|upregulation upregulation|nmod|END_ENTITY	Atorvastatin suppresses LPS-induced rapid upregulation of Toll-like_receptor_4 and its signaling pathway in endothelial cells .
24488914	0	Atorvastatin	0,12	Toll-like_receptor_4	24,44	Atorvastatin	Toll-like receptor 4	MESH:C065179	100009497(Tax:9986)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Atorvastatin suppresses Toll-like_receptor_4 expression and NF-kB activation in rabbit atherosclerotic_plaques .
15678129	0	Atorvastatin	0,12	VEGF	26,30	Atorvastatin	VEGF	MESH:C065179	22339(Tax:10090)	Chemical	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	Atorvastatin induction of VEGF and BDNF promotes brain plasticity after stroke in mice .
19811885	0	Atorvastatin	0,12	VEGF	83,87	Atorvastatin	VEGF	MESH:C065179	22339(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|regulation regulation|nmod|END_ENTITY	Atorvastatin inhibits inflammatory angiogenesis in mice through down regulation of VEGF , TNF-alpha and TGF-beta1 .
18543304	0	Atorvastatin	0,12	adiponectin	154,165	Atorvastatin	adiponectin	MESH:C065179	9370	Chemical	Gene	administration|compound|START_ENTITY administration|dep|impact impact|nmod|level level|compound|END_ENTITY	Atorvastatin administration after percutaneous coronary intervention in patients with coronary_artery_disease and normal lipid profiles : impact on plasma adiponectin level .
10595624	0	Atorvastatin	0,12	ecNOS	23,28	Atorvastatin	ecNOS	MESH:C065179	4846	Chemical	Gene	increases|compound|START_ENTITY END_ENTITY|nsubj|increases	Atorvastatin increases ecNOS levels in human platelets of hyperlipidemic subjects .
20440630	0	Atorvastatin	0,12	endothelin-1	58,70	Atorvastatin	endothelin-1	MESH:C065179	24323(Tax:10116)	Chemical	Gene	preconditioning|compound|START_ENTITY attenuates|nsubj|preconditioning attenuates|dobj|production production|nmod|END_ENTITY	Atorvastatin preconditioning attenuates the production of endothelin-1 and prevents experimental vasospasm in rats .
15326822	0	Atorvastatin	0,12	fibrinogen	21,31	Atorvastatin	fibrinogen	MESH:C065179	2244	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|levels levels|compound|END_ENTITY	Atorvastatin reduces fibrinogen levels in patients with severe hypercholesterolemia : additional evidence to support the anti-inflammatory effects of statins .
12547874	0	Atorvastatin	0,12	hepatic_lipase	40,54	Atorvastatin	hepatic lipase	MESH:C065179	3990	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|activity activity|amod|END_ENTITY	Atorvastatin dose-dependently decreases hepatic_lipase activity in type 2 diabetes : effect of sex and the LIPC promoter variant .
16207471	0	Atorvastatin	0,12	interleukin-2	21,34	Atorvastatin	interleukin-2	MESH:C065179	3558	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|END_ENTITY	Atorvastatin affects interleukin-2 signaling by altering the lipid raft enrichment of the interleukin-2_receptor beta chain .
16014304	0	Atorvastatin	0,12	leptin	27,33	Atorvastatin	leptin	MESH:C065179	100008747(Tax:9986)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|concentration concentration|compound|END_ENTITY	Atorvastatin reduces serum leptin concentration in hypercholesterolemic rabbits .
24255692	0	Atorvastatin	0,12	leptin	57,63	Atorvastatin	leptin	MESH:C065179	3952	Chemical	Gene	treatment|compound|START_ENTITY modulates|nsubj|treatment modulates|dobj|interaction interaction|nmod|END_ENTITY	Atorvastatin treatment modulates the interaction between leptin and adiponectin , and the clinical parameters in patients with type_II_diabetes .
26995052	0	Atorvastatin	0,12	miR-143	22,29	Atorvastatin	miR-143	MESH:C065179	406935	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Atorvastatin inhibits miR-143 expression : A protective mechanism against oxidative stress in cardiomyocytes .
22615115	0	Atorvastatin	0,12	myocardin	22,31	Atorvastatin	myocardin	MESH:C065179	93649	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Atorvastatin inhibits myocardin expression in vascular smooth muscle cells .
24452713	0	Atorvastatin	0,12	osteopontin	58,69	Atorvastatin	osteopontin	MESH:C065179	6696	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Atorvastatin inhibits hyperglycemia-induced expression of osteopontin in the diabetic rat kidney via the p38 MAPK pathway .
16152630	0	Atorvastatin	0,12	osteoprotegerin	42,57	Atorvastatin	osteoprotegerin	MESH:C065179	4982	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|nmod|END_ENTITY	Atorvastatin stimulates the production of osteoprotegerin by human osteoblasts .
26645604	0	Atorvastatin	0,12	p21	74,77	Atorvastatin	p21	MESH:C065179	1026	Chemical	Gene	Replication|compound|START_ENTITY Replication|nmod|END_ENTITY	Atorvastatin Restricts HIV Replication in CD4 + T Cells by Upregulation of p21 .
24452713	0	Atorvastatin	0,12	p38	105,108	Atorvastatin	p38	MESH:C065179	81649(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|kidney kidney|nmod|pathway pathway|amod|END_ENTITY	Atorvastatin inhibits hyperglycemia-induced expression of osteopontin in the diabetic rat kidney via the p38 MAPK pathway .
25849951	0	Atorvastatin	0,12	pentraxin_3	26,37	Atorvastatin	pentraxin 3	MESH:C065179	5806	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|amod|END_ENTITY	Atorvastatin reduces long pentraxin_3 expression in vascular cells by inhibiting protein geranylgeranylation .
16507303	0	Atorvastatin	0,12	plasminogen_activator_inhibitor-1	21,54	Atorvastatin	plasminogen activator inhibitor-1	MESH:C065179	18787(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|amod|END_ENTITY	Atorvastatin reduces plasminogen_activator_inhibitor-1 expression in adipose tissue of atherosclerotic rabbits .
11834533	0	Atorvastatin	0,12	platelet-activating_factor_acetylhydrolase	51,93	Atorvastatin	platelet-activating factor acetylhydrolase	MESH:C065179	5048	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|activity activity|amod|END_ENTITY	Atorvastatin preferentially reduces LDL-associated platelet-activating_factor_acetylhydrolase activity in dyslipidemias of type_IIA_and_type_IIB .
21614411	0	Atorvastatin	0,12	thrombin	21,29	Atorvastatin	thrombin	MESH:C065179	2147	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|iobj|END_ENTITY	Atorvastatin reduces thrombin generation and expression of tissue factor , P-selectin and GPIIIa on platelet-derived microparticles in patients with peripheral arterial_occlusive_disease .
19609862	0	Atorvastatin	0,12	thrombomodulin	21,35	Atorvastatin	thrombomodulin	MESH:C065179	100008887(Tax:9986)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Atorvastatin induces thrombomodulin expression in the aorta of cholesterol-fed rabbits and in TNFalpha-treated human aortic endothelial cells .
15313180	0	Atorvastatin	0,12	tissue_transglutaminase	21,44	Atorvastatin	tissue transglutaminase	MESH:C065179	7052	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Atorvastatin induces tissue_transglutaminase in human endothelial cells .
12084593	0	Atorvastatin	0,12	vascular_endothelial_growth_factor	23,57	Atorvastatin	vascular endothelial growth factor	MESH:C065179	7422	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|END_ENTITY	Atorvastatin decreases vascular_endothelial_growth_factor in patients with coronary_artery_disease .
22153388	0	Atorvastatin	0,12	vascular_endothelial_growth_factor	21,55	Atorvastatin	vascular endothelial growth factor	MESH:C065179	7422	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|amod|END_ENTITY	Atorvastatin reduces vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in human non-small_cell_lung_carcinomas -LRB- NSCLCs -RRB- via inhibition of reactive oxygen species -LRB- ROS -RRB- production .
26586210	0	Atosiban	34,42	oxytocin_receptor	4,21	Atosiban	oxytocin receptor	MESH:C047046	5021	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	The oxytocin_receptor antagonist , Atosiban , activates pro-inflammatory pathways in human amnion via Gai signalling .
17221938	0	Atractylenolide_I	0,17	TNF-alpha	77,86	Atractylenolide I	TNF-alpha	MESH:C424804	7124	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|END_ENTITY	Atractylenolide_I and atractylenolide_III inhibit Lipopolysaccharide-induced TNF-alpha and NO production in macrophages .
26536846	0	Atractylenolide_I	65,82	UDP-glucuronosyltransferase_2B7	30,61	Atractylenolide I	UDP-glucuronosyltransferase 2B7	MESH:C424804	7364	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Strong Specific Inhibition of UDP-glucuronosyltransferase_2B7 by Atractylenolide_I and III .
19069660	0	Atrazine	11,19	calmodulin	64,74	Atrazine	calmodulin	MESH:D001280	12314(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of Atrazine on the content of calcium and expression of calmodulin in splenocytes of mice -RSB- .
10665418	0	Atrazine	0,8	cytochrome_P450	22,37	Atrazine	cytochrome P450	MESH:D001280	30986(Tax:7227)	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Atrazine induction of cytochrome_P450 in Chironomus tentans larvae .
23197165	0	Atrazine	0,8	gonadotropin-releasing_hormone	28,58	Atrazine	gonadotropin-releasing hormone	MESH:D001280	25194(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|amod|END_ENTITY	Atrazine inhibits pulsatile gonadotropin-releasing_hormone -LRB- GnRH -RRB- release without altering GnRH messenger RNA or protein levels in the female rat .
2235972	0	Atropine	0,8	CCK	34,37	Atropine	CCK	MESH:D001285	25298(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|secretion secretion|compound|END_ENTITY	Atropine enhances food-stimulated CCK secretion in the rat .
3079600	0	Atropine	0,8	GH	37,39	Atropine	GH	MESH:D001285	2688	Chemical	Gene	blockade|amod|START_ENTITY blockade|nmod|growth_hormone growth_hormone|appos|END_ENTITY	Atropine blockade of growth_hormone -LRB- GH -RRB- - releasing hormone-induced GH secretion in man is not exerted at pituitary level .
3079600	0	Atropine	0,8	GH	67,69	Atropine	GH	MESH:D001285	2688	Chemical	Gene	blockade|amod|START_ENTITY blockade|nmod|growth_hormone growth_hormone|dep|releasing releasing|dobj|secretion secretion|compound|END_ENTITY	Atropine blockade of growth_hormone -LRB- GH -RRB- - releasing hormone-induced GH secretion in man is not exerted at pituitary level .
6209493	0	Atropine	0,8	arginine-vasopressin	43,63	Atropine	arginine-vasopressin	MESH:D001285	403579(Tax:9615)	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|effect effect|nmod|END_ENTITY	Atropine potentiates the pressor effect of arginine-vasopressin in conscious dogs .
6599720	0	Atropine	0,8	arginine-vasopressin	45,65	Atropine	arginine-vasopressin	MESH:D001285	403579(Tax:9615)	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|nmod|END_ENTITY	Atropine potentiates the pressor response to arginine-vasopressin in conscious dogs .
3881013	0	Atropine	0,8	cholecystokinin	21,36	Atropine	cholecystokinin	MESH:D001285	885	Chemical	Gene	antagonizes|nsubj|START_ENTITY antagonizes|dobj|evacuation evacuation|compound|END_ENTITY	Atropine antagonizes cholecystokinin and cerulein-induced gallbladder evacuation in man : a real-time ultrasonographic study .
4013785	0	Atropine	0,8	cholecystokinin	64,79	Atropine	cholecystokinin	MESH:D001285	101096837	Chemical	Gene	block|amod|START_ENTITY block|dep|contraction contraction|acl|elicited elicited|nmod|END_ENTITY	Atropine and naloxone block the colonic contraction elicited by cholecystokinin and pentagastrin .
6096959	0	Atropine	0,8	cholecystokinin	45,60	Atropine	cholecystokinin	MESH:D001285	885	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|nmod|END_ENTITY	Atropine inhibits meal-stimulated release of cholecystokinin .
7286565	0	Atropine	0,8	gastrin	20,27	Atropine	gastrin	MESH:D001285	100685087	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|release release|compound|END_ENTITY	Atropine suppresses gastrin release by food intact and vagotomized dogs .
7463371	0	Atropine	0,8	gastrin	56,63	Atropine	gastrin	MESH:D001285	100685087	Chemical	Gene	abolish|nsubj|START_ENTITY abolish|dobj|stimulation stimulation|nmod|release release|compound|END_ENTITY	Atropine does not abolish cephalic vagal stimulation of gastrin release in dogs .
3079600	0	Atropine	0,8	growth_hormone	21,35	Atropine	growth hormone	MESH:D001285	2688	Chemical	Gene	blockade|amod|START_ENTITY blockade|nmod|END_ENTITY	Atropine blockade of growth_hormone -LRB- GH -RRB- - releasing hormone-induced GH secretion in man is not exerted at pituitary level .
449693	0	Atropine	0,8	pancreatic_polypeptide	63,85	Atropine	pancreatic polypeptide	MESH:D001285	5539	Chemical	Gene	suppression|amod|START_ENTITY suppression|nmod|secretion secretion|amod|END_ENTITY	Atropine suppression of basal and metoclopramide-induced human pancreatic_polypeptide secretion in man .
78236	0	Atropine	0,8	pancreatic_polypeptide	30,52	Atropine	pancreatic polypeptide	MESH:D001285	5539	Chemical	Gene	suppression|compound|START_ENTITY test|nsubj|suppression test|nmod|END_ENTITY	Atropine suppression test for pancreatic_polypeptide .
3362847	0	Atropine	0,8	secretin	46,54	Atropine	secretin	MESH:D001285	6343	Chemical	Gene	abolishes|nsubj|START_ENTITY abolishes|dobj|effect effect|nmod|END_ENTITY	Atropine abolishes the potentiation effect of secretin and cholecystokinin-octapeptide on exocrine pancreatic secretion in humans .
24651300	0	Atsttrin	20,28	TNFRSF25	47,55	Atsttrin	TNFRSF25	null	8718	Chemical	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Progranulin-derived Atsttrin directly binds to TNFRSF25 -LRB- DR3 -RRB- and inhibits TNF-like_ligand_1A -LRB- TL1A -RRB- activity .
27011384	0	Attenuated_Isoproterenol	37,61	Myocardial_Infarction	142,163	Attenuated Isoproterenol	histamine-H3 receptor	null	85268(Tax:10116)	Chemical	Gene	Induced|nsubj|START_ENTITY Induced|nmod|END_ENTITY	Histamine H3 Receptor Agonist Imetit Attenuated_Isoproterenol Induced Renin Angiotensin System and Sympathetic Nervous System Overactivity in Myocardial_Infarction of Rats .
22548643	0	Au	68,70	glucose_oxidase	28,43	Au	glucose oxidase	null	54363	Chemical	Gene	activity|dep|START_ENTITY activity|nmod|END_ENTITY	Electrochemical activity of glucose_oxidase on a poly -LRB- ionic liquid -RRB- - Au nanoparticle composite .
18269233	0	AuI	29,32	AgI	47,50	AuI	PhN	null	1373	Chemical	Gene	complexes|compound|START_ENTITY complexes|compound|END_ENTITY	Bi - , tetra - , and hexanuclear AuI and binuclear AgI complexes and AgI coordination polymers containing phenylaminobis -LRB- phosphonite -RRB- , PhN -LCB- P -LRB- OC6H4OMe-o -RRB- 2 -RCB- 2 , and pyridyl ligands .
12161100	0	Aucubin	47,54	TNF-alpha	14,23	Aucubin	TNF-alpha	MESH:C006650	24835(Tax:10116)	Chemical	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Inhibition of TNF-alpha and IL-6 production by Aucubin through blockade of NF-kappaB activation RBL-2H3 mast cells .
8980113	0	Aureobasidin_A	0,14	MDR1	92,96	Aureobasidin A	MDR1	MESH:C071398	5243	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Aureobasidin_A , an antifungal cyclic depsipeptide antibiotic , is a substrate for both human MDR1 and MDR2/P-glycoproteins .
17474	0	Aurinetricarboxylic_acid	0,24	glucose-6-phosphate_dehydrogenase	48,81	Aurinetricarboxylic acid	glucose-6-phosphate dehydrogenase	null	281179(Tax:9913)	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	Aurinetricarboxylic_acid : a potent inhibitor of glucose-6-phosphate_dehydrogenase .
11861505	0	Aurintricarboxylic_acid	0,23	IGF-I_receptor	61,75	Aurintricarboxylic acid	IGF-I receptor	MESH:D001312	3480	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|nmod|END_ENTITY	Aurintricarboxylic_acid induces a distinct activation of the IGF-I_receptor signaling within MDA-231 cells .
19014974	0	Aurintricarboxylic_acid	0,23	neuraminidase	49,62	Aurintricarboxylic acid	neuraminidase	MESH:D001312	4758	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Aurintricarboxylic_acid inhibits influenza virus neuraminidase .
9915899	0	Aurothioglucose	0,15	thioredoxin_reductase	32,53	Aurothioglucose	thioredoxin reductase	MESH:D006051	21672(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	Aurothioglucose inhibits murine thioredoxin_reductase activity in vivo .
18448096	0	Aurothiomalate	0,14	COX-2	112,117	Aurothiomalate	COX-2	MESH:D006052	5743	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|effects effects|nmod|stability stability|compound|END_ENTITY	Aurothiomalate inhibits COX-2 expression in chondrocytes and in human cartilage possibly through its effects on COX-2 mRNA stability .
18448096	0	Aurothiomalate	0,14	COX-2	24,29	Aurothiomalate	COX-2	MESH:D006052	5743	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Aurothiomalate inhibits COX-2 expression in chondrocytes and in human cartilage possibly through its effects on COX-2 mRNA stability .
20178133	0	Aurothiomalate	0,14	cyclooxygenase_2	24,40	Aurothiomalate	cyclooxygenase 2	MESH:D006052	19225(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Aurothiomalate inhibits cyclooxygenase_2 , matrix_metalloproteinase_3 , and interleukin-6 expression in chondrocytes by increasing MAPK_phosphatase_1 expression and decreasing p38 phosphorylation : MAPK_phosphatase_1 as a novel target for antirheumatic drugs .
25314295	0	Aurothiomalate	0,14	mPGES-1	42,49	Aurothiomalate	mPGES-1	MESH:D006052	64292(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Aurothiomalate inhibits the expression of mPGES-1 in primary human chondrocytes .
11779138	0	Autocrine	0,9	CB2	49,52	Autocrine	CB2	null	1269	Chemical	Gene	regulation|amod|START_ENTITY END_ENTITY|nsubj|regulation	Autocrine and paracrine regulation of lymphocyte CB2 receptor expression by TGF-beta .
12097414	0	Autocrine	0,9	IFN-gamma	24,33	Autocrine	IFN-gamma	null	15978(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Autocrine production of IFN-gamma by macrophages controls their recruitment to kidney and the development of glomerulonephritis in MRL/lpr mice .
17668352	0	Autocrine	0,9	IGF-I	54,59	Autocrine	IGF-I	null	104978413	Chemical	Gene	production|amod|START_ENTITY production|appos|END_ENTITY	Autocrine production of insulin-like_growth_factor-I -LRB- IGF-I -RRB- affects paracellular transport across epithelial cells in vitro .
10536003	0	Autocrine	0,9	IL-3	35,39	Autocrine	IL-3	null	3562	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Autocrine production and action of IL-3 and granulocyte_colony-stimulating_factor in chronic_myeloid_leukemia .
8504493	0	Autocrine	0,9	TGF-alpha	24,33	Autocrine	TGF-alpha	null	24827(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Autocrine production of TGF-alpha and TGF-beta during tumour progression of rat oral keratinocytes .
16828470	0	Autocrine	0,9	TGF-beta	24,32	Autocrine	TGF-beta	null	59086(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Autocrine production of TGF-beta confers resistance to apoptosis after an epithelial-mesenchymal transition process in hepatocytes : Role of EGF receptor ligands .
20190033	0	Autocrine	0,9	TGF-beta1	24,33	Autocrine	TGF-beta1	null	7040	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Autocrine production of TGF-beta1 promotes myofibroblastic differentiation of neonatal lung mesenchymal stem cells .
9808147	0	Autocrine	0,9	TGFalpha	10,18	Autocrine	TGFalpha	null	7039	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Autocrine TGFalpha expression in the regulation of initiation of human colon_carcinoma growth .
17996648	0	Autocrine	0,9	TNFalpha	10,18	Autocrine	TNFalpha	null	7124	Chemical	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis .
15673292	0	Autocrine	0,9	VEGF	73,77	Autocrine	VEGF	null	83785(Tax:10116)	Chemical	Gene	functions|compound|START_ENTITY functions|appos|END_ENTITY	Autocrine and paracrine functions of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in renal tubular epithelial cells .
10953026	0	Autocrine	0,9	VEGFR-2	25,32	Autocrine	VEGFR-2	null	3791	Chemical	Gene	stimulation|amod|START_ENTITY stimulation|nmod|END_ENTITY	Autocrine stimulation of VEGFR-2 activates human leukemic cell growth and migration .
17035230	0	Autocrine	0,9	amphiregulin	36,48	Autocrine	amphiregulin	null	374	Chemical	Gene	START_ENTITY|dobj|effects effects|nmod|END_ENTITY	Autocrine and juxtacrine effects of amphiregulin on the proliferative , invasive , and migratory properties of normal and neoplastic human mammary epithelial cells .
8252633	0	Autocrine	0,9	angiotensin_II	21,35	Autocrine	angiotensin II	null	183	Chemical	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	Autocrine release of angiotensin_II mediates stretch-induced hypertrophy of cardiac myocytes in vitro .
12091250	0	Autocrine	0,9	epidermal_growth_factor_receptor	26,58	Autocrine	epidermal growth factor receptor	null	1956	Chemical	Gene	ligands|amod|START_ENTITY ligands|nmod|END_ENTITY	Autocrine ligands for the epidermal_growth_factor_receptor mediate interleukin-8 release from bronchial epithelial cells in response to cigarette smoke .
16621453	0	Autocrine	0,9	hepatocyte_growth_factor	44,68	Autocrine	hepatocyte growth factor	null	3082	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Autocrine production of biologically active hepatocyte_growth_factor -LRB- HGF -RRB- by injured human skin .
17668352	0	Autocrine	0,9	insulin-like_growth_factor-I	24,52	Autocrine	insulin-like growth factor-I	null	104978413	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Autocrine production of insulin-like_growth_factor-I -LRB- IGF-I -RRB- affects paracellular transport across epithelial cells in vitro .
11818668	0	Autocrine	0,9	interleukin-6	66,79	Autocrine	interleukin-6	null	3569	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Autocrine production and synergistic growth-promoting activity of interleukin-6 and oncostatin_M in a new human myeloma cell line TU-1 .
20236757	0	Autocrine	0,9	interleukin-6	24,37	Autocrine	interleukin-6	null	3569	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Autocrine production of interleukin-6 confers cisplatin and paclitaxel resistance in ovarian_cancer cells .
24189439	0	Autocrine	0,9	interleukin-6	24,37	Autocrine	interleukin-6	null	3569	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Autocrine production of interleukin-6 confers ovarian_cancer cells resistance to tamoxifen via ER isoforms and SRC-1 .
15746434	0	Autocrine	0,9	interleukin-8	38,51	Autocrine	interleukin-8	null	3576	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Autocrine and paracrine regulation of interleukin-8 expression in lung_cancer cells .
21742513	0	Autocrine	0,9	interleukin-8	24,37	Autocrine	interleukin-8	null	3576	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Autocrine production of interleukin-8 confers cisplatin and paclitaxel resistance in ovarian_cancer cells .
16763206	0	Autocrine	0,9	interleukin-9	21,34	Autocrine	interleukin-9	null	3578	Chemical	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	Autocrine release of interleukin-9 promotes Jak3-dependent survival of ALK + anaplastic_large-cell_lymphoma cells .
11751408	0	Autocrine	0,9	interleukin_6	24,37	Autocrine	interleukin 6	null	3569	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Autocrine production of interleukin_6 causes multidrug resistance in breast_cancer cells .
21149713	0	Auxin	0,5	PIN-FORMED_3	24,36	Auxin	PIN-FORMED 3	MESH:D007210	843432(Tax:3702)	Chemical	Gene	transport|compound|START_ENTITY transport|nmod|END_ENTITY	Auxin transport through PIN-FORMED_3 -LRB- PIN3 -RRB- controls shade avoidance and fitness during competition .
21149713	0	Auxin	0,5	PIN3	38,42	Auxin	PIN3	MESH:D007210	843432(Tax:3702)	Chemical	Gene	transport|compound|START_ENTITY transport|appos|END_ENTITY	Auxin transport through PIN-FORMED_3 -LRB- PIN3 -RRB- controls shade avoidance and fitness during competition .
18177902	0	Avarol	0,6	TNF-alpha	16,25	Avarol	TNF-alpha	MESH:C023663	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|generation generation|amod|END_ENTITY	Avarol inhibits TNF-alpha generation and NF-kappaB activation in human cells and in animal models .
23523950	0	Avermectin	0,10	P-glycoprotein	19,33	Avermectin	P-glycoprotein	MESH:C019264	38726(Tax:7227)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Avermectin induces P-glycoprotein expression in S2 cells via the calcium/calmodulin/NF-kB pathway .
19876699	0	Axitinib	0,8	VEGF	75,79	Axitinib	VEGF	MESH:C503983	7422	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|receptor receptor|appos|END_ENTITY	Axitinib -- a selective inhibitor of the vascular endothelial growth factor -LRB- VEGF -RRB- receptor .
16890436	0	Aza-stilbenes	0,13	c-RAF	38,43	Aza-stilbenes	c-RAF	null	5894	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Aza-stilbenes as potent and selective c-RAF inhibitors .
11933676	0	Azaberbene	0,10	alpha_2A-adrenoceptor	26,47	Azaberbene	alpha 2A-adrenoceptor	null	150	Chemical	Gene	START_ENTITY|nmod|antagonists antagonists|amod|END_ENTITY	Azaberbene derivatives as alpha_2A-adrenoceptor antagonists .
20149650	0	Azabicyclic_sulfonamides	0,24	11beta-HSD1	35,46	Azabicyclic sulfonamides	11beta-HSD1	null	15483(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Azabicyclic_sulfonamides as potent 11beta-HSD1 inhibitors .
22329436	0	Azaindenoisoquinolines	0,22	topoisomerase_I	26,41	Azaindenoisoquinolines	topoisomerase I	null	7150	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Azaindenoisoquinolines as topoisomerase_I inhibitors and potential anticancer agents : a systematic study of structure-activity relationships .
26168340	0	Azanitrile	0,10	Cathepsin_K	11,22	Azanitrile	Cathepsin K	null	1513	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|compound|END_ENTITY	Azanitrile Cathepsin_K Inhibitors : Effects on Cell Toxicity , Osteoblast-Induced Mineralization and Osteoclast-Mediated Bone Resorption .
24262766	0	Azapirone	0,9	5-HT1A_receptor	10,25	Azapirone	5-HT1A receptor	null	3350	Chemical	Gene	treatment|amod|START_ENTITY treatment|amod|END_ENTITY	Azapirone 5-HT1A_receptor partial agonist treatment for major_depressive_disorder : systematic review and meta-analysis .
8439517	0	Azasteroids	0,11	5_alpha-reductase	42,59	Azasteroids	5 alpha-reductase	MESH:D001378	6715	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Azasteroids as inhibitors of testosterone 5_alpha-reductase in mammalian skin .
23476126	0	Azastilbene	0,11	tyrosinase	23,33	Azastilbene	tyrosinase	null	7299	Chemical	Gene	analogs|amod|START_ENTITY analogs|nmod|inhibitors inhibitors|amod|END_ENTITY	Azastilbene analogs as tyrosinase inhibitors : new molecules with depigmenting potential .
14651577	0	Azathioprine	0,12	thiopurine_methyl_transferase	80,109	Azathioprine	thiopurine methyl transferase	MESH:D001379	7172	Chemical	Gene	START_ENTITY|nmod|children children|nmod|deficiency deficiency|amod|END_ENTITY	Azathioprine as a treatment for severe atopic_eczema in children with a partial thiopurine_methyl_transferase -LRB- TPMT -RRB- deficiency .
21594311	0	Azatyrosine	0,11	c-Raf-1	39,46	Azatyrosine	c-Raf-1	null	110157(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	Azatyrosine inhibits the activation of c-Raf-1 , c-Jun and AP1 but not the activation of Ras during signal transduction triggered by oncogenic c-ErbB-2 .
19104905	0	Azelaoyl_PAF	19,31	PPAR-gamma	0,10	Azelaoyl PAF	PPAR-gamma	null	5468	Chemical	Gene	increases|compound|START_ENTITY increases|amod|END_ENTITY	PPAR-gamma agonist Azelaoyl_PAF increases frataxin protein and mRNA expression : new implications for the Friedreich 's _ ataxia therapy .
14646384	0	Azelastine	0,10	IL-6	33,37	Azelastine	IL-6	MESH:C020976	3569	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|nmod|END_ENTITY	Azelastine inhibits secretion of IL-6 , TNF-alpha and IL-8 as well as NF-kappaB activation and intracellular calcium ion levels in normal human mast cells .
15071361	0	Azelnidipine	0,12	interleukin-8	109,122	Azelnidipine	interleukin-8	MESH:C061679	3576	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Azelnidipine , a newly developed long-acting calcium antagonist , inhibits tumor_necrosis_factor-alpha-induced interleukin-8 expression in endothelial cells through its anti-oxidative properties .
24900758	0	Azepine	49,56	BET	57,60	Azepine	BET	CHEBI:48105	92737	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|compound|END_ENTITY	Discovery , Design , and Optimization of Isoxazole Azepine BET Inhibitors .
7582985	0	Azetidin-2-one	0,14	thrombin	44,52	Azetidin-2-one	thrombin	CHEBI:327119	2147	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Azetidin-2-one derivatives as inhibitors of thrombin .
25005084	0	Azide	0,5	urate_oxidase	20,33	Azide	urate oxidase	CHEBI:40910	391051	Chemical	Gene	START_ENTITY|dobj|inhibition inhibition|nmod|END_ENTITY	Azide inhibition of urate_oxidase .
16797627	0	Azidothymidine	0,14	p14ARF	38,44	Azidothymidine	p14ARF	MESH:D015215	1029	Chemical	Gene	increase|nsubj|START_ENTITY increase|dobj|expression expression|amod|END_ENTITY	Azidothymidine and cisplatin increase p14ARF expression in OVCAR-3 ovarian_cancer cell line .
24819928	0	Azilsartan	0,10	OPG	108,111	Azilsartan	OPG	MESH:C521273	25341(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|nmod|END_ENTITY	Azilsartan increases levels of IL-10 , down-regulates MMP-2 , MMP-9 , RANKL/RANK , Cathepsin_K and up-regulates OPG in an experimental periodontitis model .
26879328	0	Azilsartan	0,10	angiotensin_II_type_1_receptor	15,45	Azilsartan	angiotensin II type 1 receptor	MESH:C521273	81638(Tax:10116)	Chemical	Gene	START_ENTITY|appos|blocker blocker|amod|END_ENTITY	Azilsartan , an angiotensin_II_type_1_receptor blocker , attenuates tert-butyl_hydroperoxide-induced endothelial cell injury through inhibition of mitochondrial dysfunction and anti-inflammatory activity .
23922555	0	Azilsartan_Medoxomil	42,62	Angiotensin_II	10,24	Azilsartan Medoxomil	Angiotensin II	MESH:C557413	24179(Tax:10116)	Chemical	Gene	Resistance|compound|START_ENTITY Resistance|compound|END_ENTITY	The Novel Angiotensin_II Receptor Blocker Azilsartan_Medoxomil Ameliorates Insulin Resistance Induced by Chronic Angiotensin_II Treatment in Rat Skeletal Muscle .
19073171	0	Azinomycin_epoxide	0,18	apoptosis_signal-regulating_kinase_1	41,77	Azinomycin epoxide	apoptosis signal-regulating kinase 1	MESH:C515726	4217	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|nmod|END_ENTITY	Azinomycin_epoxide induces activation of apoptosis_signal-regulating_kinase_1 -LRB- ASK1 -RRB- and caspase_3 in a HIF-1alpha-independent manner in human leukaemia myeloid macrophages .
21597298	0	Azithromycin	0,12	IL-5	22,26	Azithromycin	IL-5	MESH:D017963	3567	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	Azithromycin inhibits IL-5 production of T helper type 2 cells from asthmatic children .
21740970	0	Azithromycin	0,12	MMP-9	23,28	Azithromycin	MMP-9	MESH:D017963	4318	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|compound|END_ENTITY	Azithromycin decreases MMP-9 expression in the airways of lung transplant recipients .
27014238	0	Azithromycin	44,56	PA3297	0,6	Azithromycin	PA3297	MESH:D017963	882460(Tax:208964)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|compound|END_ENTITY	PA3297 Counteracts Antimicrobial Effects of Azithromycin in Pseudomonas_aeruginosa .
26625370	0	Azithromycin	0,12	Tumor_Necrosis_Factor	33,54	Azithromycin	Tumor Necrosis Factor	MESH:D017963	7124	Chemical	Gene	Secretion|compound|START_ENTITY Secretion|compound|END_ENTITY	Azithromycin Inhibits Macrophage Tumor_Necrosis_Factor Secretion in Response to Both Azithromycin-Susceptible and Azithromycin-Resistant Pneumococci .
21195124	0	Azithromycin	0,12	interleukin-1b	33,47	Azithromycin	interleukin-1b	MESH:D017963	16176(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Azithromycin inhibits macrophage interleukin-1b production through inhibition of activator_protein-1 in lipopolysaccharide-induced murine pulmonary_neutrophilia .
17210769	0	Azithromycin	0,12	tumor_necrosis_factor_alpha	33,60	Azithromycin	tumor necrosis factor alpha	MESH:D017963	7124	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|levels levels|compound|END_ENTITY	Azithromycin selectively reduces tumor_necrosis_factor_alpha levels in cystic_fibrosis airway epithelial cells .
26801032	0	B	73,74	AlC	106,109	B	AlC	null	55821	Chemical	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Hyperfine rather than spin splittings dominate the fine structure of the B -LRB- 4 -RRB- -LRB- - -RRB- - X -LRB- 4 -RRB- -LRB- - -RRB- bands of AlC .
22395615	0	B-RAF	50,55	B-RAF	88,93	B-RAF	B-RAF	null	673	Chemical	Gene	START_ENTITY|dobj|resistance resistance|compound|END_ENTITY	Melanoma whole-exome sequencing identifies -LRB- V600E -RRB- B-RAF amplification-mediated acquired B-RAF inhibitor resistance .
9339747	5	B-Se	789,793	B-Cd	849,853	B-Se	B-Cd	null	285440	Chemical	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	In the multiple linear regression analysis , B-Se as a dependent variable was negatively associated with B-Cd , whereas current smoking habits were not included in the model as a predictor variable .
12646227	0	B-crystallin	28,40	Hsp27	85,90	B-crystallin	Hsp27	null	3315	Chemical	Gene	stability|nmod|START_ENTITY stability|nmod|END_ENTITY	Enhanced stability of alpha B-crystallin in the presence of small heat_shock protein Hsp27 .
22237773	0	B-vitamins	0,10	MTHFR	49,54	B-vitamins	MTHFR	null	4524	Chemical	Gene	START_ENTITY|appos|methylenetetrahydrofolate_reductase methylenetetrahydrofolate_reductase|appos|END_ENTITY	B-vitamins , methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- and hypertension .
12817477	0	B8Gly	41,46	insulin	69,76	B8Gly	insulin	null	3630	Chemical	Gene	Contribution|nmod|START_ENTITY Contribution|nmod|END_ENTITY	Contribution of the absolutely conserved B8Gly to the foldability of insulin .
21348786	0	BAPA	0,4	Factor_Xa	36,45	BAPA	Factor Xa	null	2159	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	BAPA , a synthetic dual inhibitor of Factor_Xa and Thrombin , extends the storage-time to a maximum of 12 hours in ADP - and 24 hours in arachidonic_acid-induced impedance aggregometry .
11590892	0	BAPTA	21,26	AP-2	67,71	BAPTA	AP-2	MESH:C025603	7020	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|END_ENTITY	The calcium chelator BAPTA affects the binding of assembly protein AP-2 to membranes .
15087455	0	BASH_N	47,53	BNAS2	83,88	BASH N	BNAS2	null	68119(Tax:10090)	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Identification and characterization of a novel BASH_N terminus-associated protein , BNAS2 .
22658294	0	BAX499	50,56	tissue_factor_pathway_inhibitor	74,105	BAX499	tissue factor pathway inhibitor	MESH:C577143	7035	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Studies on the mechanism of action of the aptamer BAX499 , an inhibitor of tissue_factor_pathway_inhibitor .
22951415	0	BAX499	10,16	tissue_factor_pathway_inhibitor	28,59	BAX499	tissue factor pathway inhibitor	MESH:C577143	21788(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY aptamer|nsubj|Effect aptamer|nmod|function function|compound|END_ENTITY	Effect of BAX499 aptamer on tissue_factor_pathway_inhibitor function and thrombin generation in models of hemophilia .
19646807	0	BAY117082	40,49	NFkappaB	20,28	BAY117082	NFkappaB	MESH:C434003	4790	Chemical	Gene	induce|nsubj|START_ENTITY inhibitors|ccomp|induce inhibitors|nsubj|END_ENTITY	The pharmacological NFkappaB inhibitors BAY117082 and MG132 induce cell arrest and apoptosis in leukemia cells through ROS-mitochondria pathway activation .
10087002	0	BAY_10-6734	11,22	angiotensin_II	43,57	BAY 10-6734	angiotensin II	MESH:C109119	24179(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|antagonist antagonist|amod|END_ENTITY	Effects of BAY_10-6734 -LRB- Embusartan -RRB- , a new angiotensin_II type I receptor antagonist , on vascular smooth muscle cell growth .
26760770	0	BAY_1024767	0,11	androgen_receptor	19,36	BAY 1024767	androgen receptor	null	367	Chemical	Gene	mutants|compound|START_ENTITY mutants|compound|END_ENTITY	BAY_1024767 blocks androgen_receptor mutants found in castration-resistant prostate_cancer patients .
23955632	0	BAY_1075553	26,37	prostate-specific_membrane_antigen	75,109	BAY 1075553	prostate-specific membrane antigen	null	2346	Chemical	Gene	evaluation|nmod|START_ENTITY evaluation|nmod|END_ENTITY	Preclinical evaluation of BAY_1075553 , a novel -LRB- 18 -RRB- F-labelled inhibitor of prostate-specific_membrane_antigen for PET imaging of prostate_cancer .
16142309	0	BAY_11-7082	88,99	NF-kappaB	104,113	BAY 11-7082	NF-kappaB	MESH:C434003	4790	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Enhancement of TPA-induced growth inhibition and apoptosis in myeloid_leukemia cells by BAY_11-7082 , an NF-kappaB inhibitor .
12083747	0	BAY_11-7082	34,45	endothelin-1	57,69	BAY 11-7082	endothelin-1	MESH:C434003	1906	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|production production|amod|END_ENTITY	A nuclear factor-kappaB inhibitor BAY_11-7082 suppresses endothelin-1 production in cultured vascular endothelial cells .
14560113	0	BAY_11-7085	88,99	alpha-melanocyte-stimulating_hormone	26,62	BAY 11-7085	alpha-melanocyte-stimulating hormone	MESH:C416282	24664(Tax:10116)	Chemical	Gene	therapy|nmod|START_ENTITY therapy|amod|END_ENTITY	Delayed administration of alpha-melanocyte-stimulating_hormone or combined therapy with BAY_11-7085 protects against gut ischemia-reperfusion injury .
16507829	0	BAY_43-9006	0,11	RET	36,39	BAY 43-9006	RET	MESH:C471405	19713(Tax:10090)	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	BAY_43-9006 inhibition of oncogenic RET mutants .
24405637	0	BAY_55-9837	23,34	SMN	45,48	BAY 55-9837	SMN	MESH:C409214	20595(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|compound|END_ENTITY	VPAC2 receptor agonist BAY_55-9837 increases SMN protein levels and moderates_disease phenotype in severe spinal_muscular_atrophy mouse models .
16328318	0	BAY_59-7939	50,61	Factor_Xa	79,88	BAY 59-7939	Factor Xa	MESH:C503223	2159	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY pharmacokinetics|dep|inhibitor inhibitor|compound|END_ENTITY	Safety , pharmacodynamics , and pharmacokinetics of BAY_59-7939 -- an oral , direct Factor_Xa inhibitor -- after multiple dosing in healthy male subjects .
16409461	0	BAY_59-7939	39,50	Factor_Xa	13,22	BAY 59-7939	Factor Xa	MESH:C503223	2159	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|END_ENTITY	Oral , direct Factor_Xa inhibition with BAY_59-7939 for the prevention of venous_thromboembolism after total hip replacement .
17100983	0	BAY_59-7939	13,24	Factor_Xa	43,52	BAY 59-7939	Factor Xa	MESH:C503223	2159	Chemical	Gene	Rivaroxaban|appos|START_ENTITY Rivaroxaban|dep|inhibitor inhibitor|compound|END_ENTITY	Rivaroxaban -LRB- BAY_59-7939 -RRB- -- an oral , direct Factor_Xa inhibitor -- has no clinically relevant interaction with naproxen .
17116766	0	BAY_59-7939	61,72	Factor_Xa	27,36	BAY 59-7939	Factor Xa	MESH:C503223	2159	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	A once-daily , oral , direct Factor_Xa inhibitor , rivaroxaban -LRB- BAY_59-7939 -RRB- , for thromboprophylaxis after total hip replacement .
17292948	0	BAY_59-7939	38,49	Factor_Xa	68,77	BAY 59-7939	Factor Xa	MESH:C503223	2159	Chemical	Gene	rivaroxaban|appos|START_ENTITY study|nmod|rivaroxaban study|dep|inhibitor inhibitor|compound|END_ENTITY	Dose-escalation study of rivaroxaban -LRB- BAY_59-7939 -RRB- -- an oral , direct Factor_Xa inhibitor -- for the prevention of venous_thromboembolism in patients undergoing total hip replacement .
17576867	0	BAY_59-7939	97,108	Factor_Xa	138,147	BAY 59-7939	Factor Xa	MESH:C503223	2159	Chemical	Gene	rivaroxaban|appos|START_ENTITY deep-vein_thrombosis|nmod|rivaroxaban Treatment|nmod|deep-vein_thrombosis Treatment|dep|ODIXa-DVT ODIXa-DVT|dep|BAY_59-7939 BAY_59-7939|compound|END_ENTITY	Treatment of proximal deep-vein_thrombosis with the oral direct factor_Xa inhibitor rivaroxaban -LRB- BAY_59-7939 -RRB- : the ODIXa-DVT -LRB- Oral Direct Factor_Xa Inhibitor BAY_59-7939 in Patients With Acute Symptomatic Deep-Vein_Thrombosis -RRB- study .
16161994	0	BAY_59-7939	156,167	factor_Xa	186,195	BAY 59-7939	factor Xa	MESH:C503223	2159	Chemical	Gene	2-carboxamide|appos|START_ENTITY 2-carboxamide|dep|inhibitor inhibitor|compound|END_ENTITY	Discovery of the novel antithrombotic agent 5-chloro-N - -LRB- -LCB- -LRB- 5S -RRB- -2 - oxo-3 - _ -LSB- 4 - -LRB- 3-oxomorpholin-4-yl -RRB- phenyl -RSB- -1,3 - oxazolidin-5-yl -RCB- methyl -RRB- thiophene - _ 2-carboxamide -LRB- BAY_59-7939 -RRB- : an oral , direct factor_Xa inhibitor .
16638738	0	BAY_59-7939	82,93	factor_Xa	125,134	BAY 59-7939	factor Xa	MESH:C503223	2159	Chemical	Gene	absorption|nmod|START_ENTITY absorption|appos|inhibitor inhibitor|compound|END_ENTITY	Effect of food , an antacid , and the H2 antagonist ranitidine on the absorption of BAY_59-7939 -LRB- rivaroxaban -RRB- , an oral , direct factor_Xa inhibitor , in healthy subjects .
17576867	0	BAY_59-7939	158,169	factor_Xa	64,73	BAY 59-7939	factor Xa	MESH:C503223	2159	Chemical	Gene	ODIXa-DVT|dep|START_ENTITY Treatment|dep|ODIXa-DVT Treatment|nmod|deep-vein_thrombosis deep-vein_thrombosis|nmod|rivaroxaban rivaroxaban|compound|END_ENTITY	Treatment of proximal deep-vein_thrombosis with the oral direct factor_Xa inhibitor rivaroxaban -LRB- BAY_59-7939 -RRB- : the ODIXa-DVT -LRB- Oral Direct Factor_Xa Inhibitor BAY_59-7939 in Patients With Acute Symptomatic Deep-Vein_Thrombosis -RRB- study .
17576867	0	BAY_59-7939	97,108	factor_Xa	64,73	BAY 59-7939	factor Xa	MESH:C503223	2159	Chemical	Gene	rivaroxaban|appos|START_ENTITY rivaroxaban|compound|END_ENTITY	Treatment of proximal deep-vein_thrombosis with the oral direct factor_Xa inhibitor rivaroxaban -LRB- BAY_59-7939 -RRB- : the ODIXa-DVT -LRB- Oral Direct Factor_Xa Inhibitor BAY_59-7939 in Patients With Acute Symptomatic Deep-Vein_Thrombosis -RRB- study .
18412020	0	BAY_60-2770	68,79	soluble_guanylate_cyclase	39,64	BAY 60-2770	soluble guanylate cyclase	MESH:C528797	25206(Tax:10116)	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Nitric_oxide-independent activation of soluble_guanylate_cyclase by BAY_60-2770 in experimental liver fibrosis .
21217076	0	BAY_60-2770	88,99	soluble_guanylyl_cyclase	52,76	BAY 60-2770	soluble guanylyl cyclase	MESH:C528797	497757(Tax:10116)	Chemical	Gene	activator|appos|START_ENTITY activator|amod|END_ENTITY	Pulmonary and systemic vasodilator responses to the soluble_guanylyl_cyclase activator , BAY_60-2770 , are not dependent on endogenous nitric_oxide or reduced heme .
24170767	0	BAY_80-6946	0,11	PI3K	46,50	BAY 80-6946	PI3K	null	5290	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|compound|END_ENTITY	BAY_80-6946 is a highly selective intravenous PI3K inhibitor with potent p110a and p110 activities in tumor cell lines and xenograft models .
24170767	0	BAY_80-6946	0,11	p110a	73,78	BAY 80-6946	p110a	null	5290	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	BAY_80-6946 is a highly selective intravenous PI3K inhibitor with potent p110a and p110 activities in tumor cell lines and xenograft models .
1378812	0	BAY_K_8644	123,133	calcitonin	22,32	BAY K 8644	calcitonin	MESH:D001498	24241(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|nmod|END_ENTITY	In vitro secretion of calcitonin from a rat C cell line : effect of repetitive stimulation with the calcium channel agonist BAY_K_8644 .
2437873	0	BAY_K_8644	0,10	renin	48,53	BAY K 8644	renin	MESH:D001498	24715(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|compound|END_ENTITY	BAY_K_8644 , a calcium channel agonist , inhibits renin secretion in vitro .
7692205	0	BAY_K_8644	0,10	renin	20,25	BAY K 8644	renin	MESH:D001498	24715(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|compound|END_ENTITY	BAY_K_8644 inhibits renin secretion in isolated perfused rat kidneys .
21814170	0	BAY_PP1	58,65	peroxisome_proliferator-activated_receptor-a	4,48	BAY PP1	peroxisome proliferator-activated receptor-a	MESH:C572615	25747(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	The peroxisome_proliferator-activated_receptor-a agonist , BAY_PP1 , attenuates renal_fibrosis in rats .
8031320	0	BAY_X1005	68,77	5-lipoxygenase	183,197	BAY X1005	5-lipoxygenase	MESH:C079315	240	Chemical	Gene	activity|nmod|START_ENTITY inhibition|nmod|activity inhibition|dep|implications implications|nmod|function function|nmod|protein protein|amod|END_ENTITY	Inversely-correlated inhibition of human 5-lipoxygenase activity by BAY_X1005 and other quinoline derivatives in intact cells and a cell-free system -- implications for the function of 5-lipoxygenase activating protein .
8031320	0	BAY_X1005	68,77	5-lipoxygenase	41,55	BAY X1005	5-lipoxygenase	MESH:C079315	240	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Inversely-correlated inhibition of human 5-lipoxygenase activity by BAY_X1005 and other quinoline derivatives in intact cells and a cell-free system -- implications for the function of 5-lipoxygenase activating protein .
11718996	0	BAY_X_3702	50,60	BCL-2	64,69	BAY X 3702	BCL-2	MESH:C111221	24224(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|level level|compound|END_ENTITY	Effect of 5-hydroxytryptamine 1A receptor agonist BAY_X_3702 on BCL-2 and BAX proteins level in the ipsilateral cerebral cortex of rats after transient focal ischaemia .
1839139	0	BAY_u3405	0,9	thromboxane_A2_receptor	34,57	BAY u3405	thromboxane A2 receptor	MESH:C063119	6915	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	BAY_u3405 , a potent and selective thromboxane_A2_receptor antagonist on airway smooth muscle in vitro .
9870646	0	BAY_u_3405	26,36	thromboxane_A2_receptor	41,64	BAY u 3405	thromboxane A2 receptor	MESH:C063119	6915	Chemical	Gene	effect|appos|START_ENTITY effect|appos|antagonist antagonist|amod|END_ENTITY	The effect of ramatroban -LRB- BAY_u_3405 -RRB- , a thromboxane_A2_receptor antagonist , on nasal cavity volume and minimum cross-sectional area and nasal mucosal hemodynamics after nasal mucosal allergen challenge in patients with perennial_allergic_rhinitis .
9196518	0	BAYx_1005	146,155	5-lipoxygenase	100,114	BAYx 1005	5-lipoxygenase	MESH:C079315	240	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Attenuation of early and late phase allergen-induced bronchoconstriction in asthmatic subjects by a 5-lipoxygenase activating protein antagonist , BAYx_1005 .
14606604	10	BB-2516	1445,1452	MMP-2	1394,1399	BB-2516	MMP-2	MESH:C100342	4313	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|activation activation|compound|END_ENTITY	MMP-2 activation and cell growth were inhibited by BB-2516 in a dose-dependent manner .
11430464	0	BCEAB	36,41	chymase	17,24	BCEAB	chymase	null	1215	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	An orally active chymase inhibitor , BCEAB , suppresses heart chymase activity in the hamster .
12359638	0	BCEAB	100,105	chymase	81,88	BCEAB	chymase	null	1215	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Suppression of basic_fibroblast_growth_factor-induced angiogenesis by a specific chymase inhibitor , BCEAB , through the chymase-angiotensin-dependent pathway in hamster sponge granulomas .
9493603	0	BCH-2763	0,8	thrombin	36,44	BCH-2763	thrombin	MESH:C111479	29251(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	BCH-2763 , a novel potent parenteral thrombin inhibitor , is an effective antithrombotic agent in rodent models of arterial and venous_thrombosis -- comparisons with heparin , r-hirudin , hirulog , inogatran and argatroban .
9684808	0	BCH-2763	17,25	thrombin	58,66	BCH-2763	thrombin	MESH:C111479	29251(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Effective use of BCH-2763 , a new potent injectable direct thrombin inhibitor , in combination with tissue_plasminogen_activator -LRB- tPA -RRB- in a rat arterial thrombolysis model .
9684808	0	BCH-2763	17,25	tissue_plasminogen_activator	98,126	BCH-2763	tissue plasminogen activator	MESH:C111479	25692(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	Effective use of BCH-2763 , a new potent injectable direct thrombin inhibitor , in combination with tissue_plasminogen_activator -LRB- tPA -RRB- in a rat arterial thrombolysis model .
10375391	0	BCH_2763	26,34	thrombin	49,57	BCH 2763	thrombin	MESH:C111479	2147	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|inhibitor inhibitor|compound|END_ENTITY	Antithrombotic effects of BCH_2763 , a new direct thrombin inhibitor , in a canine model of venous_thrombosis .
6622814	0	BCNU	15,19	glutathione_reductase	118,139	BCNU	glutathione reductase	MESH:D002330	14782(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|enzymes enzymes|amod|END_ENTITY	The effects of BCNU -LRB- 1,3-bis -LRB- 2-chloroethyl -RRB- -1 - nitrosourea -RRB- and CCNU -LRB- 1 - -LRB- 2-chloroethyl -RRB- -3 - cyclohexyl-1-nitrosourea -RRB- on glutathione_reductase and other enzymes in mouse tissue .
6623510	0	BCNU	14,18	glutathione_reductase	42,63	BCNU	glutathione reductase	MESH:D002330	14782(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|compound|END_ENTITY	The effect of BCNU -LRB- carmustine -RRB- on tissue glutathione_reductase activity .
18448481	9	BCP	1317,1320	COX-1	1337,1342	BCP	COX-1	null	4512	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Inhibition of protein kinase C -LRB- PKC -RRB- and extracellular regulated kinase 1/2 -LRB- ERK1/2 -RRB- signal transduction pathways blocked BCP crystal-induced COX-1 mRNA expression .
24218150	0	BDE-47	16,22	CAR	62,65	BDE-47	CAR	MESH:C517826	9970	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Flame retardant BDE-47 effectively activates nuclear receptor CAR in human primary hepatocytes .
22738989	0	BDE-99	24,30	CYP2B6	78,84	BDE-99	CYP2B6	MESH:C477694	1555	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|dep|role role|nmod|END_ENTITY	Oxidative metabolism of BDE-99 by human liver microsomes : predominant role of CYP2B6 .
21180172	0	BDM	41,44	myosin	24,30	BDM	myosin	null	79784	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|inhibitor inhibitor|compound|END_ENTITY	-LSB- Non-specific effect of myosin inhibitor BDM on skeletal muscle contractile function -RSB- .
17085854	0	BD_1047	10,17	sigma1_receptor	21,36	BD 1047	sigma1 receptor	MESH:C097963	18391(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Effect of BD_1047 , a sigma1_receptor antagonist , in the animal models predictive of antipsychotic activity .
15793245	0	BETA2/NeuroD1	35,48	Neuronatin	0,10	BETA2/NeuroD1	Neuronatin	null	4826	Chemical	Gene	target|nmod|START_ENTITY END_ENTITY|appos|target	Neuronatin , a downstream target of BETA2/NeuroD1 in the pancreas , is involved in glucose-mediated insulin secretion .
26779597	0	BEZ235	106,112	phosphoinositol-3-kinase	23,47	BEZ235	phosphoinositol-3-kinase	MESH:C531198	5290	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|study study|nmod|END_ENTITY	Phase II study of dual phosphoinositol-3-kinase -LRB- PI3K -RRB- and mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitor BEZ235 in patients with locally advanced or metastatic transitional_cell_carcinoma -LRB- TCC -RRB- .
21681585	0	BGC20-1531	30,40	prostanoid_EP4_receptor	50,73	BGC20-1531	prostanoid EP4 receptor	MESH:C541956	5734	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	The pharmacological effect of BGC20-1531 , a novel prostanoid_EP4_receptor antagonist , in the prostaglandin_E2 human model of headache .
24681892	6	BGN	724,727	FAK	765,768	BGN	BGN	null	633	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	BGN induces increased phosphorylation of FAK -LRB- Tyr576/577 , Tyr925 and Tyr397 -RRB- and Paxillin .
10837473	0	BH3	80,83	BAD	50,53	BH3	BAD	MESH:C006008	572	Chemical	Gene	domain|compound|START_ENTITY phosphorylation|nmod|domain inactivate|nmod|phosphorylation inactivate|dobj|END_ENTITY	Growth factors inactivate the cell death promoter BAD by phosphorylation of its BH3 domain on Ser155 .
10949026	0	BH3	68,71	BAD	61,64	BH3	BAD	MESH:C006008	572	Chemical	Gene	phosphorylation|compound|START_ENTITY inactivate|nmod|phosphorylation inactivate|dobj|END_ENTITY	14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation .
11464217	0	BH3	4,7	BAD	18,21	BH3	BAD	MESH:C006008	572	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	The BH3 domain of BAD fused to the Antennapedia peptide induces apoptosis via its alpha helical structure and independent of Bcl-2 .
12965220	0	BH3	27,30	BAD	12,15	BH3	BAD	MESH:C006008	572	Chemical	Gene	domain|compound|START_ENTITY END_ENTITY|nmod|domain	Mutation of BAD within the BH3 domain impairs its phosphorylation-mediated regulation .
9305851	0	BH3	0,3	BAD	14,17	BH3	BAD	MESH:C006008	572	Chemical	Gene	domain|nummod|START_ENTITY domain|nmod|END_ENTITY	BH3 domain of BAD is required for heterodimerization with BCL-XL and pro-apoptotic activity .
24120870	3	BH3	537,540	BAK	622,625	BH3	BAK	MESH:C006008	578	Chemical	Gene	ABT-737|compound|START_ENTITY BCL-XL|nmod|ABT-737 neutralization|nmod|BCL-XL resulted|nsubj|neutralization show|ccomp|resulted show|parataxis|BIM BIM|nsubj|END_ENTITY	Employing a `` BCL-XL-addiction '' model , we show that neutralization of BCL-XL by the BH3 mimetic ABT-737 resulted in death only when cells were reconstituted with BCL-XL : BAK , but not BCL-2 / BCL-XL : BIM complexes .
11583631	0	BH3	26,29	BAX	63,66	BH3	BAX	MESH:C006008	581	Chemical	Gene	molecules|nummod|START_ENTITY molecules|acl|preventing preventing|dobj|END_ENTITY	BCL-2 , BCL-X -LRB- L -RRB- sequester BH3 domain-only molecules preventing BAX - and BAK-mediated mitochondrial apoptosis .
17052454	0	BH3	14,17	BAX	53,56	BH3	BAX	MESH:C006008	581	Chemical	Gene	helix|compound|START_ENTITY binds|nsubj|helix binds|dobj|END_ENTITY	A stapled BID BH3 helix directly binds and activates BAX .
22544745	0	BH3	36,39	BAX	68,71	BH3	BAX	MESH:C006008	581	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|protein protein|compound|END_ENTITY	The MUC1-C oncoprotein binds to the BH3 domain of the pro-apoptotic BAX protein and blocks BAX function .
25118931	0	BH3	76,79	BAX	72,75	BH3	BAX	MESH:C006008	12028(Tax:10090)	Chemical	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	Improving the therapeutic potential of endostatin by fusing it with the BAX BH3 death domain .
26913490	0	BH3	114,117	BAX	75,78	BH3	BAX	MESH:C006008	581	Chemical	Gene	Peptide|compound|START_ENTITY Underlying|nmod|Peptide Underlying|dobj|Activation Activation|nmod|END_ENTITY	Evidence for an Induced-fit Process Underlying the Activation of Apoptotic BAX by an Intrinsically Disordered Bim BH3 Peptide .
9742125	0	BH3	19,22	BAX	33,36	BH3	BAX	MESH:C006008	581	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Mutagenesis of the BH3 domain of BAX identifies residues critical for dimerization and killing .
10837489	0	BH3	126,129	BCL-2	48,53	BH3	BCL-2	MESH:C006008	596	Chemical	Gene	domain|compound|START_ENTITY possessing|dobj|domain protein|acl|possessing encodes|dobj|protein encodes|nsubj|MCL-1S MCL-1S|appos|variant variant|nmod|MCL-1 MCL-1|compound|END_ENTITY	MCL-1S , a splicing variant of the antiapoptotic BCL-2 family member MCL-1 , encodes a proapoptotic protein possessing only the BH3 domain .
11583631	0	BH3	26,29	BCL-2	0,5	BH3	BCL-2	MESH:C006008	596	Chemical	Gene	molecules|nummod|START_ENTITY sequester|dobj|molecules sequester|nsubj|BCL-X BCL-X|compound|END_ENTITY	BCL-2 , BCL-X -LRB- L -RRB- sequester BH3 domain-only molecules preventing BAX - and BAK-mediated mitochondrial apoptosis .
12662143	0	BH3	0,3	BCL-2	15,20	BH3	BCL-2	MESH:C006008	596	Chemical	Gene	domains|nummod|START_ENTITY domains|nmod|inhibitors inhibitors|compound|END_ENTITY	BH3 domains as BCL-2 inhibitors : prototype cancer therapeutics .
18084238	0	BH3	0,3	BCL-2	74,79	BH3	BCL-2	MESH:C006008	596	Chemical	Gene	domains|nsubj|START_ENTITY domains|xcomp|define define|nmod|END_ENTITY	BH3 domains define selective inhibitory interactions with BHRF-1 and KSHV BCL-2 .
18596739	0	BH3	51,54	BCL-2	0,5	BH3	BCL-2	MESH:C006008	596	Chemical	Gene	mimetic|advmod|START_ENTITY GX15-070|amod|mimetic modulates|nmod|GX15-070 modulates|nsubj|phosphorylation phosphorylation|compound|END_ENTITY	BCL-2 phosphorylation modulates sensitivity to the BH3 mimetic GX15-070 -LRB- Obatoclax -RRB- and reduces its synergistic interaction with bortezomib in chronic_lymphocytic_leukemia cells .
21168768	0	BH3	22,25	BCL-2	50,55	BH3	BCL-2	MESH:C006008	596	Chemical	Gene	peptides|nsubj|START_ENTITY peptides|xcomp|dissect dissect|dobj|interactome interactome|compound|END_ENTITY	Photoreactive stapled BH3 peptides to dissect the BCL-2 family interactome .
23845444	0	BH3	25,28	BCL-2	10,15	BH3	BCL-2	MESH:C006008	596	Chemical	Gene	ABT-199|compound|START_ENTITY END_ENTITY|nmod|ABT-199	Targeting BCL-2 with the BH3 mimetic ABT-199 in estrogen_receptor-positive breast_cancer .
24983357	0	BH3	135,138	BCL-2	22,27	BH3	BCL-2	MESH:C006008	596	Chemical	Gene	mimetics|nummod|START_ENTITY using|dobj|mimetics resistance|acl|using targeting|dobj|resistance offers|advcl|targeting offers|nsubj|profiling profiling|nmod|members members|compound|END_ENTITY	Clinical profiling of BCL-2 family members in the setting of BRAF inhibition offers a rationale for targeting de novo resistance using BH3 mimetics .
25096574	0	BH3	45,48	BCL-2	163,168	BH3	BCL-2	MESH:C006008	596	Chemical	Gene	domain|appos|START_ENTITY mimetics|nsubj|domain mimetics|xcomp|demonstrate demonstrate|xcomp|dependent dependent|nmod|repertoire repertoire|nmod|proteins proteins|compound|END_ENTITY	B_cell_lymphoma-2 -LRB- BCL-2 -RRB- homology domain 3 -LRB- BH3 -RRB- mimetics demonstrate differential activities dependent upon the functional repertoire of pro- and anti-apoptotic BCL-2 family proteins .
25096574	0	BH3	45,48	BCL-2	19,24	BH3	BCL-2	MESH:C006008	596	Chemical	Gene	domain|appos|START_ENTITY domain|compound|END_ENTITY	B_cell_lymphoma-2 -LRB- BCL-2 -RRB- homology domain 3 -LRB- BH3 -RRB- mimetics demonstrate differential activities dependent upon the functional repertoire of pro- and anti-apoptotic BCL-2 family proteins .
25687043	0	BH3	22,25	BCL-2	55,60	BH3	BCL-2	MESH:C006008	596	Chemical	Gene	S1|compound|START_ENTITY S1|nmod|Members Members|compound|END_ENTITY	-LSB- Relationship Between BH3 mimetic S1 and Expression of BCL-2 Family Members in Acute Myeloid_Leukemia . -RSB-
9575197	0	BH3	62,65	BCL-2	19,24	BH3	BCL-2	MESH:C006008	596	Chemical	Gene	domain|compound|START_ENTITY contains|dobj|domain contains|nsubj|BNIP3 BNIP3|compound|END_ENTITY	Adenovirus E1B-19K / BCL-2 interacting protein BNIP3 contains a BH3 domain and a mitochondrial targeting sequence .
10419515	0	BH3	28,31	BID	58,61	BH3	BID	MESH:C006008	637	Chemical	Gene	member|compound|START_ENTITY activity|nmod|member Ion|dobj|activity Ion|dep|END_ENTITY	Ion channel activity of the BH3 only Bcl-2 family member , BID .
16826547	0	BH3	35,38	BID	62,65	BH3	BID	MESH:C006008	637	Chemical	Gene	motif|compound|START_ENTITY motif|nmod|END_ENTITY	NMR determination that an extended BH3 motif of pro-apoptotic BID is specifically bound to BCL-XL .
24398548	0	BH3	20,23	BID	58,61	BH3	BID	MESH:C006008	637	Chemical	Gene	interacting|advmod|START_ENTITY gene|amod|interacting gene|appos|END_ENTITY	Association between BH3 interacting domain death agonist -LRB- BID -RRB- gene polymorphism and ossification_of_the_posterior_longitudinal_ligament in Korean population .
24621205	0	BH3	15,18	BID	53,56	BH3	BID	MESH:C006008	637	Chemical	Gene	interacting|advmod|START_ENTITY gene|amod|interacting gene|appos|END_ENTITY	Association of BH3 interacting domain death agonist -LRB- BID -RRB- gene polymorphisms with proteinuria of immunoglobulin A nephropathy .
8918887	0	BH3	13,16	BID	0,3	BH3	BID	MESH:C006008	637	Chemical	Gene	agonist|compound|START_ENTITY END_ENTITY|dep|agonist	BID : a novel BH3 domain-only death agonist .
10822388	0	BH3	52,55	BNIP1	83,88	BH3	BNIP1	MESH:C006008	662	Chemical	Gene	domain|nummod|START_ENTITY domain|nmod|END_ENTITY	Functional identification of the apoptosis effector BH3 domain in cellular protein BNIP1 .
16484005	0	BH3	0,3	Bad	42,45	BH3	Bad	MESH:C006008	572	Chemical	Gene	mutation|compound|START_ENTITY mutation|nmod|genes genes|amod|END_ENTITY	BH3 domain mutation of proapoptotic genes Bad , Bmf and Bcl-G is rare in transitional_cell_carcinomas of the urinary bladder .
17557568	0	BH3	27,30	Bad	74,77	BH3	Bad	MESH:C006008	572	Chemical	Gene	domains|nummod|START_ENTITY analysis|nmod|domains analysis|dep|END_ENTITY	Mutational analysis of the BH3 domains of proapoptotic Bcl-2 family genes Bad , Bmf and Bcl-G in laryngeal_squamous_cell_carcinomas .
18452209	0	BH3	46,49	Bad	81,84	BH3	Bad	MESH:C006008	572	Chemical	Gene	complex|nmod|START_ENTITY peptides|amod|complex peptides|nmod|END_ENTITY	Anti-apoptotic Bcl-XL protein in complex with BH3 peptides of pro-apoptotic Bak , Bad , and Bim proteins : comparative molecular dynamics simulations .
9372935	0	BH3	9,12	Bad	0,3	BH3	Bad	MESH:C006008	12015(Tax:10090)	Chemical	Gene	protein|compound|START_ENTITY protein|nsubj|END_ENTITY	Bad is a BH3 domain-containing protein that forms an inactivating dimer with Bcl-XL .
15143800	0	BH3	52,55	Bak	92,95	BH3	Bak	MESH:C006008	578	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Molecular dynamics study of peptide segments of the BH3 domain of the proapoptotic proteins Bak , Bax , Bid and Hrk bound to the Bcl-xL and Bcl-2 proteins .
15590665	0	BH3	37,40	Bak	53,56	BH3	Bak	MESH:C006008	578	Chemical	Gene	isoform|compound|START_ENTITY isoform|compound|END_ENTITY	Neurons exclusively express N-Bak , a BH3 domain-only Bak isoform that promotes neuronal_apoptosis .
16439990	0	BH3	28,31	Bak	42,45	BH3	Bak	MESH:C006008	578	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Interaction of F1L with the BH3 domain of Bak is responsible for inhibiting vaccinia-induced apoptosis .
17452531	0	BH3	41,44	Bak	104,107	BH3	Bak	MESH:C006008	578	Chemical	Gene	ligands|nummod|START_ENTITY ligands|acl|engaging engaging|dobj|relatives relatives|appos|END_ENTITY	Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives , not Bak .
18471982	0	BH3	38,41	Bak	22,25	BH3	Bak	MESH:C006008	578	Chemical	Gene	domain|compound|START_ENTITY exposes|dobj|domain exposes|nsubj|END_ENTITY	To trigger apoptosis , Bak exposes its BH3 domain and homodimerizes via BH3 : groove interactions .
10773818	0	BH3	4,7	Bax	73,76	BH3	Bax	MESH:C006008	581	Chemical	Gene	domain|compound|START_ENTITY required|nsubjpass|domain required|nmod|death death|acl|induced induced|nmod|END_ENTITY	The BH3 domain is required for caspase-independent cell death induced by Bax and oligomycin .
11997495	0	BH3	40,43	Bax	87,90	BH3	Bax	MESH:C006008	581	Chemical	Gene	Bim|compound|START_ENTITY isoforms|nmod|Bim isoforms|acl:relcl|activate activate|dobj|END_ENTITY	Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis .
12093270	0	BH3	97,100	Bax	111,114	BH3	Bax	MESH:C006008	373637(Tax:8355)	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Interaction between the antiapoptotic protein Nr-13 and cytochrome c. Antagonistic effect of the BH3 domain of Bax .
14659760	0	BH3	105,108	Bax	119,122	BH3	Bax	MESH:C006008	581	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Specific interaction of the antiapoptotic protein Nr-13 with phospholipid monolayers is prevented by the BH3 domain of Bax .
15846080	0	BH3	21,24	Bax	14,17	BH3	Bax	MESH:C006008	581	Chemical	Gene	domains|nummod|START_ENTITY END_ENTITY|nmod|domains	Activation of Bax by BH3 domains during apoptosis : the unfolding of a deadly plot .
17671092	0	BH3	53,56	Bax	110,113	BH3	Bax	MESH:C006008	12028(Tax:10090)	Chemical	Gene	containing|dobj|START_ENTITY domain|acl|containing responsible|nsubj|domain responsible|nmod|activity activity|nmod|END_ENTITY	A three-helix homo-oligomerization domain containing BH3 and BH1 is responsible for the apoptotic activity of Bax .
19813621	0	BH3	8,11	Bax	4,7	BH3	Bax	MESH:C006008	581	Chemical	Gene	H2-H3|compound|START_ENTITY H2-H3|compound|END_ENTITY	The Bax BH3 peptide H2-H3 promotes apoptosis by inhibiting Bcl-2 's pore-forming and anti-Bax activities in the membrane .
21148306	0	BH3	4,7	Bax	105,108	BH3	Bax	MESH:C006008	581	Chemical	Gene	alpha-helical|compound|START_ENTITY mimic|nsubj|alpha-helical mimic|dobj|Bcl-X Bcl-X|appos|interactions interactions|nmod|END_ENTITY	The BH3 alpha-helical mimic BH3-M6 disrupts Bcl-X -LRB- L -RRB- , Bcl-2 , and MCL-1 protein-protein interactions with Bax , Bak , Bad , or Bim and induces apoptosis in a Bax - and Bim-dependent manner .
21199865	0	BH3	27,30	Bax	12,15	BH3	Bax	MESH:C006008	12028(Tax:10090)	Chemical	Gene	domain|compound|START_ENTITY END_ENTITY|nmod|domain	Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis .
23283967	0	BH3	73,76	Bax	22,25	BH3	Bax	MESH:C006008	581	Chemical	Gene	proteins|nmod|START_ENTITY proteins|compound|END_ENTITY	Direct interaction of Bax and Bak proteins with Bcl-2 homology domain 3 -LRB- BH3 -RRB- - only proteins in living cells revealed by fluorescence complementation .
23374347	0	BH3	34,37	Bax	0,3	BH3	Bax	MESH:C006008	581	Chemical	Gene	domains|compound|START_ENTITY activate|nsubj|domains reveal|ccomp|activate reveal|nsubj|structures structures|compound|END_ENTITY	Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis .
23374347	0	BH3	34,37	Bax	55,58	BH3	Bax	MESH:C006008	581	Chemical	Gene	domains|compound|START_ENTITY activate|nsubj|domains activate|xcomp|END_ENTITY	Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis .
26158515	0	BH3	38,41	Bax	21,24	BH3	Bax	MESH:C006008	581	Chemical	Gene	peptide|compound|START_ENTITY bound|nmod|peptide END_ENTITY|acl|bound	Crystal structure of Bax bound to the BH3 peptide of Bim identifies important contacts for interaction .
8631771	0	BH3	99,102	Bax	21,24	BH3	Bax	MESH:C006008	581	Chemical	Gene	domain|appos|START_ENTITY Bax|nmod|domain heterodimerizes|nmod|Bax heterodimerizes|nsubj|END_ENTITY	Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain -LRB- BH3 -RRB- distinct from BH1 and BH2 .
8631771	0	BH3	99,102	Bax	75,78	BH3	Bax	MESH:C006008	581	Chemical	Gene	domain|appos|START_ENTITY END_ENTITY|nmod|domain	Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain -LRB- BH3 -RRB- distinct from BH1 and BH2 .
9363757	0	BH3	4,7	Bax	18,21	BH3	Bax	MESH:C006008	581	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	The BH3 domain of Bax is sufficient for interaction of Bax with itself and with other family members and it is required for induction of apoptosis .
9363757	0	BH3	4,7	Bax	55,58	BH3	Bax	MESH:C006008	581	Chemical	Gene	domain|compound|START_ENTITY sufficient|nsubj|domain sufficient|nmod|interaction interaction|nmod|END_ENTITY	The BH3 domain of Bax is sufficient for interaction of Bax with itself and with other family members and it is required for induction of apoptosis .
10419515	0	BH3	28,31	Bcl-2	37,42	BH3	Bcl-2	MESH:C006008	596	Chemical	Gene	member|compound|START_ENTITY member|compound|END_ENTITY	Ion channel activity of the BH3 only Bcl-2 family member , BID .
10625696	0	BH3	100,103	Bcl-2	82,87	BH3	Bcl-2	MESH:C006008	596	Chemical	Gene	domain|appos|START_ENTITY domain|amod|END_ENTITY	BNIP3 heterodimerizes with Bcl-2 / Bcl-X -LRB- L -RRB- and induces cell death independent of a Bcl-2 homology 3 -LRB- BH3 -RRB- domain at both mitochondrial and nonmitochondrial sites .
12135371	0	BH3	22,25	Bcl-2	37,42	BH3	Bcl-2	MESH:C006008	596	Chemical	Gene	domains|nummod|START_ENTITY domains|nmod|members members|compound|END_ENTITY	Peptides derived from BH3 domains of Bcl-2 family members : a comparative analysis of inhibition of Bcl-2 , Bcl-x -LRB- L -RRB- and Bax oligomerization , induction of cytochrome_c release , and activation of cell death .
12135371	0	BH3	22,25	Bcl-2	99,104	BH3	Bcl-2	MESH:C006008	596	Chemical	Gene	domains|nummod|START_ENTITY derived|nmod|domains Peptides|acl|derived Peptides|dep|analysis analysis|nmod|inhibition inhibition|nmod|END_ENTITY	Peptides derived from BH3 domains of Bcl-2 family members : a comparative analysis of inhibition of Bcl-2 , Bcl-x -LRB- L -RRB- and Bax oligomerization , induction of cytochrome_c release , and activation of cell death .
12388545	0	BH3	63,66	Bcl-2	45,50	BH3	Bcl-2	MESH:C006008	24224(Tax:10116)	Chemical	Gene	Bim|compound|START_ENTITY Bim|amod|END_ENTITY	Nerve_growth_factor -LRB- NGF -RRB- down-regulates the Bcl-2 homology 3 -LRB- BH3 -RRB- domain-only protein Bim and suppresses its proapoptotic activity by phosphorylation .
12700646	0	BH3	75,78	Bcl-2	47,52	BH3	Bcl-2	MESH:C006008	596	Chemical	Gene	family|nmod|START_ENTITY family|compound|END_ENTITY	Bfk : a novel weakly proapoptotic member of the Bcl-2 protein family with a BH3 and a BH2 region .
15006371	0	BH3	50,53	Bcl-2	90,95	BH3	Bcl-2	MESH:C006008	596	Chemical	Gene	peptides|nummod|START_ENTITY peptides|acl|derived derived|nmod|proteins proteins|compound|END_ENTITY	Synthesis and helical structure of lactam bridged BH3 peptides derived from pro-apoptotic Bcl-2 family proteins .
17097561	0	BH3	4,7	Bcl-2	42,47	BH3	Bcl-2	MESH:C006008	12043(Tax:10090)	Chemical	Gene	ABT-737|compound|START_ENTITY targets|nsubj|ABT-737 targets|dobj|proteins proteins|compound|END_ENTITY	The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized .
17452531	0	BH3	41,44	Bcl-2	83,88	BH3	Bcl-2	MESH:C006008	596	Chemical	Gene	ligands|nummod|START_ENTITY ligands|acl|engaging engaging|dobj|relatives relatives|compound|END_ENTITY	Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives , not Bak .
17557568	0	BH3	27,30	Bcl-2	55,60	BH3	Bcl-2	MESH:C006008	596	Chemical	Gene	domains|nummod|START_ENTITY domains|nmod|genes genes|compound|END_ENTITY	Mutational analysis of the BH3 domains of proapoptotic Bcl-2 family genes Bad , Bmf and Bcl-G in laryngeal_squamous_cell_carcinomas .
17971900	0	BH3	65,68	Bcl-2	24,29	BH3	Bcl-2	MESH:C006008	596	Chemical	Gene	peptides|compound|START_ENTITY Targeting|nmod|peptides Targeting|dobj|members members|compound|END_ENTITY	Targeting antiapoptotic Bcl-2 family members with cell-permeable BH3 peptides induces apoptosis signaling and death in head_and_neck_squamous_cell_carcinoma cells .
18292288	0	BH3	40,43	Bcl-2	10,15	BH3	Bcl-2	MESH:C006008	12043(Tax:10090)	Chemical	Gene	members|nmod|START_ENTITY members|compound|END_ENTITY	Targeting Bcl-2 family members with the BH3 mimetic AT-101 markedly enhances the therapeutic effects of chemotherapeutic agents in in vitro and in vivo models of B-cell_lymphoma .
18778689	0	BH3	57,60	Bcl-2	23,28	BH3	Bcl-2	MESH:C006008	596	Chemical	Gene	domain|compound|START_ENTITY proteins|nmod|domain proteins|nummod|END_ENTITY	Apoptosis induction by Bcl-2 proteins independent of the BH3 domain .
19813621	0	BH3	8,11	Bcl-2	59,64	BH3	Bcl-2	MESH:C006008	596	Chemical	Gene	H2-H3|compound|START_ENTITY promotes|nsubj|H2-H3 promotes|advcl|inhibiting inhibiting|dobj|pore-forming pore-forming|nmod:npmod|END_ENTITY	The Bax BH3 peptide H2-H3 promotes apoptosis by inhibiting Bcl-2 's pore-forming and anti-Bax activities in the membrane .
19893570	0	BH3	0,3	Bcl-2	89,94	BH3	Bcl-2	MESH:C006008	596	Chemical	Gene	profiles|nummod|START_ENTITY predict|nsubj|profiles predict|dobj|activity activity|nmod|antagonists antagonists|compound|END_ENTITY	BH3 response profiles from neuroblastoma mitochondria predict activity of small molecule Bcl-2 family antagonists .
20503275	0	BH3	8,11	Bcl-2	86,91	BH3	Bcl-2	MESH:C006008	12043(Tax:10090)	Chemical	Gene	potently|nummod|START_ENTITY induces|nsubj|potently induces|advcl|targeting targeting|xcomp|END_ENTITY	A novel BH3 mimetic S1 potently induces Bax/Bak-dependent apoptosis by targeting both Bcl-2 and Mcl-1 .
20534453	0	BH3	0,3	Bcl-2	49,54	BH3	Bcl-2	MESH:C006008	12043(Tax:10090)	Chemical	Gene	mimetics|nummod|START_ENTITY mimetics|acl|antagonizing antagonizing|dobj|proteins proteins|compound|END_ENTITY	BH3 mimetics antagonizing restricted prosurvival Bcl-2 proteins represent another class of selective immune modulatory drugs .
21148306	0	BH3	4,7	Bcl-2	54,59	BH3	Bcl-2	MESH:C006008	596	Chemical	Gene	alpha-helical|compound|START_ENTITY mimic|nsubj|alpha-helical mimic|dobj|Bcl-X Bcl-X|appos|interactions interactions|amod|END_ENTITY	The BH3 alpha-helical mimic BH3-M6 disrupts Bcl-X -LRB- L -RRB- , Bcl-2 , and MCL-1 protein-protein interactions with Bax , Bak , Bad , or Bim and induces apoptosis in a Bax - and Bim-dependent manner .
21189256	0	BH3	64,67	Bcl-2	83,88	BH3	Bcl-2	MESH:C006008	596	Chemical	Gene	peptides|appos|START_ENTITY peptides|nmod|proteins proteins|compound|END_ENTITY	Amphipathic tail-anchoring peptide and Bcl-2 homology domain-3 -LRB- BH3 -RRB- peptides from Bcl-2 family proteins induce apoptosis through different mechanisms .
21393385	0	BH3	29,32	Bcl-2	119,124	BH3	Bcl-2	MESH:C006008	596	Chemical	Gene	domain|appos|START_ENTITY reveals|nsubj|domain reveals|dobj|regulation regulation|nmod|bad bad|appos|protein protein|nmod|family family|compound|END_ENTITY	The Bcl-2 homology domain 3 -LRB- BH3 -RRB- mimetic ABT-737 reveals the dynamic regulation of bad , a proapoptotic protein of the Bcl-2 family , by Bcl-xL .
21393385	0	BH3	29,32	Bcl-2	4,9	BH3	Bcl-2	MESH:C006008	596	Chemical	Gene	domain|appos|START_ENTITY domain|compound|END_ENTITY	The Bcl-2 homology domain 3 -LRB- BH3 -RRB- mimetic ABT-737 reveals the dynamic regulation of bad , a proapoptotic protein of the Bcl-2 family , by Bcl-xL .
21454712	4	BH3	1003,1006	Bcl-2	997,1002	BH3	Bcl-2	MESH:C006008	596	Chemical	Gene	groove|compound|START_ENTITY groove|compound|END_ENTITY	Further analysis showed that the Noxa/Bcl -2 interaction reflected binding between the Noxa BH3 domain and the Bcl-2 BH3 binding groove .
21527247	0	BH3	26,29	Bcl-2	70,75	BH3	Bcl-2	MESH:C006008	596	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|clusterin clusterin|nmod|END_ENTITY	Interaction of a putative BH3 domain of clusterin with anti-apoptotic Bcl-2 family proteins as revealed by NMR spectroscopy .
22565822	7	BH3	1013,1016	Bcl-2	1027,1032	BH3	Bcl-2	MESH:C006008	596	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Computational modeling showed that emodin could directly bind to the BH3 domain of Bcl-2 through forming one hydrogen bond with Ala146 residue in Bcl-2 .
22579788	0	BH3	4,7	Bcl-2	73,78	BH3	Bcl-2	MESH:C006008	596	Chemical	Gene	S1|compound|START_ENTITY induces|nsubj|S1 induces|nmod|stress stress|nmod|interaction interaction|compound|END_ENTITY	The BH3 mimetic S1 induces autophagy through ER stress and disruption of Bcl-2 / Beclin_1 interaction in human glioma U251 cells .
22702834	0	BH3	38,41	Bcl-2	69,74	BH3	Bcl-2	MESH:C006008	596	Chemical	Gene	specificity|compound|START_ENTITY specificity|nmod|END_ENTITY	In silico and in vitro elucidation of BH3 binding specificity toward Bcl-2 .
22895112	0	BH3	30,33	Bcl-2	63,68	BH3	Bcl-2	MESH:C006008	596	Chemical	Gene	proteins|compound|START_ENTITY proteins|nmod|proteins proteins|compound|END_ENTITY	Interactions of pro-apoptotic BH3 proteins with anti-apoptotic Bcl-2 family proteins measured in live MCF-7 cells using FLIM FRET .
23192964	0	BH3	114,117	Bcl-2	141,146	BH3	Bcl-2	MESH:C006008	12043(Tax:10090)	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|members members|compound|END_ENTITY	Nuclear magnetic resonance study of protein-protein interactions involving apoptosis regulator Diva -LRB- Boo -RRB- and the BH3 domain of proapoptotic Bcl-2 members .
23460874	0	BH3	48,51	Bcl-2	77,82	BH3	Bcl-2	MESH:C006008	596	Chemical	Gene	domain|compound|START_ENTITY prodiginines|nmod|domain interactions|nmod|prodiginines interactions|nmod|members members|compound|END_ENTITY	Molecular interactions of prodiginines with the BH3 domain of anti-apoptotic Bcl-2 family members .
23466888	0	BH3	58,61	Bcl-2	10,15	BH3	Bcl-2	MESH:C006008	100049703(Tax:9823)	Chemical	Gene	chelerythrine|compound|START_ENTITY revealed|nmod|chelerythrine motifs|acl|revealed motifs|compound|END_ENTITY	Canonical Bcl-2 motifs of the Na + / K + pump revealed by the BH3 mimetic chelerythrine : early signal transducers of apoptosis ?
23651073	0	BH3	60,63	Bcl-2	92,97	BH3	Bcl-2	MESH:C006008	596	Chemical	Gene	maturation|nmod|START_ENTITY strategies|nmod|maturation comparison|nmod|strategies peptide|nsubj|comparison peptide|nmod|proteins proteins|compound|END_ENTITY	A comparison of two strategies for affinity maturation of a BH3 peptide toward pro-survival Bcl-2 proteins .
23651505	0	BH3	14,17	Bcl-2	78,83	BH3	Bcl-2	MESH:C006008	596	Chemical	Gene	S1|nummod|START_ENTITY cells|nsubj|S1 cells|dobj|END_ENTITY	Resistance to BH3 mimetic S1 in SCLC cells that up-regulate and phosphorylate Bcl-2 through ERK1/2 .
23746270	0	BH3	14,17	Bcl-2	28,33	BH3	Bcl-2	MESH:C006008	596	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|proteins proteins|compound|END_ENTITY	Targeting the BH3 domain of Bcl-2 family proteins .
23860449	0	BH3	19,22	Bcl-2	4,9	BH3	Bcl-2	MESH:C006008	596	Chemical	Gene	ABT-199|compound|START_ENTITY ABT-199|compound|END_ENTITY	The Bcl-2 specific BH3 mimetic ABT-199 : a promising targeted therapy for t -LRB- 11 ; 14 -RRB- multiple myeloma .
23986435	0	BH3	29,32	Bcl-2	117,122	BH3	Bcl-2	MESH:C006008	12043(Tax:10090)	Chemical	Gene	active|nsubj|START_ENTITY active|nmod|proteins proteins|compound|END_ENTITY	The Bcl-2 homology domain 3 -LRB- BH3 -RRB- - only proteins Bim and bid are functionally active and restrained by anti-apoptotic Bcl-2 family proteins in healthy liver .
24218065	0	BH3	73,76	Bcl-2	14,19	BH3	Bcl-2	MESH:C006008	596	Chemical	Gene	regions|compound|START_ENTITY dynamics|nmod|regions CED-9|dep|dynamics CED-9|compound|END_ENTITY	Antiapoptotic Bcl-2 homolog CED-9 in Caenorhabditis_elegans : dynamics of BH3 and CED-4 binding regions and comparison with mammalian antiapoptotic Bcl-2 proteins .
25324174	0	BH3	8,11	Bcl-2	109,114	BH3	Bcl-2	MESH:C006008	596	Chemical	Gene	mimetic|nummod|START_ENTITY efficiently|nmod:npmod|mimetic induces|advmod|efficiently induces|nmod|proteins proteins|amod|binding binding|nmod|family family|compound|END_ENTITY	A novel BH3 mimetic efficiently induces apoptosis in melanoma cells through direct binding to anti-apoptotic Bcl-2 family proteins , including phosphorylated Mcl-1 .
25371206	0	BH3	161,164	Bcl-2	143,148	BH3	Bcl-2	MESH:C006008	596	Chemical	Gene	Domains|appos|START_ENTITY Depend|nsubj|Domains Depend|nmod|END_ENTITY	The Functional Differences between Pro-survival and Pro-apoptotic B_Cell_Lymphoma_2 -LRB- Bcl-2 -RRB- Proteins Depend on Structural Differences in Their Bcl-2 Homology 3 -LRB- BH3 -RRB- Domains .
25371206	0	BH3	161,164	Bcl-2	85,90	BH3	Bcl-2	MESH:C006008	596	Chemical	Gene	Domains|appos|START_ENTITY Depend|nsubj|Domains Depend|dep|Proteins Proteins|nsubj|Differences Differences|nmod|B_Cell_Lymphoma_2 B_Cell_Lymphoma_2|appos|END_ENTITY	The Functional Differences between Pro-survival and Pro-apoptotic B_Cell_Lymphoma_2 -LRB- Bcl-2 -RRB- Proteins Depend on Structural Differences in Their Bcl-2 Homology 3 -LRB- BH3 -RRB- Domains .
25373508	0	BH3	11,14	Bcl-2	49,54	BH3	Bcl-2	MESH:C006008	596	Chemical	Gene	mimetic|compound|START_ENTITY mimetic|acl:relcl|targets targets|xcomp|END_ENTITY	ABT-199 , a BH3 mimetic that specifically targets Bcl-2 , enhances the antitumor activity of chemotherapy , bortezomib and JQ1 in `` double hit '' lymphoma cells .
25641608	0	BH3	162,165	Bcl-2	12,17	BH3	Bcl-2	MESH:C006008	596	Chemical	Gene	Mimetic|compound|START_ENTITY Created|nmod|Mimetic Created|nsubj|Inhibitors Inhibitors|amod|END_ENTITY	Novel Mcl-1 / Bcl-2 Dual Inhibitors Created by the Structure-Based Hybridization of Drug-Divided Building Blocks and a Fragment Deconstructed from a Known Two-Face BH3 Mimetic .
25740993	0	BH3	0,3	Bcl-2	64,69	BH3	Bcl-2	MESH:C006008	596	Chemical	Gene	Profiling|compound|START_ENTITY Reveals|nsubj|Profiling Reveals|nmod|Herpesviruses Herpesviruses|nmod|Proteins Proteins|compound|END_ENTITY	BH3 Profiling Reveals Selectivity by Herpesviruses for Specific Bcl-2 Proteins to Mediate Survival of Latently Infected Cells .
26079328	0	BH3	82,85	Bcl-2	0,5	BH3	Bcl-2	MESH:C006008	596	Chemical	Gene	mimetics|nummod|START_ENTITY way|nmod|mimetics family|dep|way family|amod|END_ENTITY	Bcl-2 family of proteins as drug targets for cancer chemotherapy : the long way of BH3 mimetics from bench to bedside .
26174630	0	BH3	0,3	Bcl-2	53,58	BH3	Bcl-2	MESH:C006008	596	Chemical	Gene	profiling|compound|START_ENTITY identifies|nsubj|profiling identifies|nmod|members members|compound|END_ENTITY	BH3 profiling identifies heterogeneous dependency on Bcl-2 family members in multiple myeloma and predicts sensitivity to BH3 mimetics .
26392332	0	BH3	73,76	Bcl-2	16,21	BH3	Bcl-2	MESH:C006008	596	Chemical	Gene	mimetics|nummod|START_ENTITY resistant|nmod:npmod|mimetics acute_lymphoblastic_leukemia|amod|resistant apoptosis|nmod|acute_lymphoblastic_leukemia triggers|dobj|apoptosis triggers|nsubj|Co-targeting Co-targeting|nmod|END_ENTITY	Co-targeting of Bcl-2 and mTOR pathway triggers synergistic apoptosis in BH3 mimetics resistant acute_lymphoblastic_leukemia .
26493374	0	BH3	86,89	Bcl-2	0,5	BH3	Bcl-2	MESH:C006008	596	Chemical	Gene	ABT-737|compound|START_ENTITY cells|nmod|ABT-737 resistance|nmod|cells confers|dobj|resistance confers|nsubj|phosphorylation phosphorylation|amod|END_ENTITY	Bcl-2 phosphorylation confers resistance of chronic_lymphocytic_leukemia cells to the BH3 mimetic ABT-737 , ABT-263 and ABT-199 by impeding direct binding .
8631771	0	BH3	99,102	Bcl-2	46,51	BH3	Bcl-2	MESH:C006008	596	Chemical	Gene	domain|appos|START_ENTITY Bax|nmod|domain heterodimerizes|nmod|Bax heterodimerizes|nmod|END_ENTITY	Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain -LRB- BH3 -RRB- distinct from BH1 and BH2 .
9731710	0	BH3	53,56	Bcl-2	153,158	BH3	Bcl-2	MESH:C006008	596	Chemical	Gene	protein|compound|START_ENTITY protein|amod|capable capable|nmod|dimerization dimerization|nmod|members members|compound|END_ENTITY	BOD -LRB- Bcl-2-related ovarian_death gene -RRB- is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members .
9731710	0	BH3	53,56	Bcl-2	88,93	BH3	Bcl-2	MESH:C006008	596	Chemical	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	BOD -LRB- Bcl-2-related ovarian_death gene -RRB- is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members .
9804769	0	BH3	60,63	Bcl-2	26,31	BH3	Bcl-2	MESH:C006008	596	Chemical	Gene	domain|compound|START_ENTITY Bok|nmod|domain Bok|compound|END_ENTITY	A splicing variant of the Bcl-2 member Bok with a truncated BH3 domain induces apoptosis but does not dimerize with antiapoptotic Bcl-2 proteins in vitro .
11687955	0	BH3	63,66	Bcl-X	41,46	BH3	Bcl-X	MESH:C006008	598	Chemical	Gene	domain|compound|START_ENTITY role|nmod|domain Killing|dep|role Killing|nmod|END_ENTITY	Killing of sarcoma cells by proapoptotic Bcl-X -LRB- S -RRB- : role of the BH3 domain and regulation by Bcl-X -LRB- L -RRB- .
10490606	0	BH3	4,7	Bcl-x	18,23	BH3	Bcl-x	MESH:C006008	598	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	The BH3 domain of Bcl-x -LRB- S -RRB- is required for inhibition of the antiapoptotic function of Bcl-x -LRB- L -RRB- .
16288206	0	BH3	90,93	Bcl-x	8,13	BH3	Bcl-x	MESH:C006008	598	Chemical	Gene	domain|compound|START_ENTITY triggers|nmod|domain triggers|nsubj|product product|amod|END_ENTITY	A novel Bcl-x splice product , Bcl-xAK , triggers apoptosis in human melanoma cells without BH3 domain .
17659302	0	BH3	115,118	Beclin-1	129,137	BH3	Beclin-1	MESH:C006008	8678	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Molecular basis of Bcl-xL 's target recognition versatility revealed by the structure of Bcl-xL in complex with the BH3 domain of Beclin-1 .
18769111	2	BH3	496,499	Beclin_1	526,534	BH3	Beclin 1	MESH:C006008	8678	Chemical	Gene	binding|nmod|START_ENTITY END_ENTITY|amod|binding	Several years ago , JNK-mediated Bcl-2 phosphorylation was shown to interfere with its binding to proapoptotic BH3 domain-containing proteins such as Bax and recently , our laboratory demonstrated that JNK1-mediated Bcl-2 phosphorylation interferes with its binding to the proautophagy BH3 domain-containing protein Beclin_1 .
22579788	0	BH3	4,7	Beclin_1	79,87	BH3	Beclin 1	MESH:C006008	8678	Chemical	Gene	S1|compound|START_ENTITY induces|nsubj|S1 induces|nmod|stress stress|nmod|interaction interaction|compound|END_ENTITY	The BH3 mimetic S1 induces autophagy through ER stress and disruption of Bcl-2 / Beclin_1 interaction in human glioma U251 cells .
14583606	5	BH3	714,717	Bid	645,648	BH3	Bid	MESH:C006008	637	Chemical	Gene	domain|compound|START_ENTITY contains|nmod|domain contains|nsubj|END_ENTITY	Bid -LRB- S -RRB- contains the N-terminal regulatory domains of Bid without the BH3 domain ; Bid -LRB- EL -RRB- corresponds to full-length Bid with additional N-terminal sequence ; and Bid -LRB- ES -RRB- contains only the Bid sequence downstream of the BH3 domain .
18329683	0	BH3	92,95	Bid	147,150	BH3	Bid	MESH:C006008	637	Chemical	Gene	activators|compound|START_ENTITY activators|nmod|restrictions restrictions|nmod|END_ENTITY	A179L , a viral Bcl-2 homologue , targets the core Bcl-2 apoptotic machinery and its upstream BH3 activators with selective binding restrictions for Bid and Noxa .
19641510	0	BH3	16,19	Bid	0,3	BH3	Bid	MESH:C006008	637	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|dep|protein	Bid : a Bax-like BH3 protein .
18467496	0	BH3	139,142	Bim	135,138	BH3	Bim	MESH:C006008	10018	Chemical	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	Hydrophile scanning as a complement to alanine scanning for exploring and manipulating protein-protein recognition : application to the Bim BH3 domain .
22040025	0	BH3	97,100	Bim	93,96	BH3	Bim	MESH:C006008	12125(Tax:10090)	Chemical	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	Evaluation of diverse a/b-backbone patterns for functional a-helix mimicry : analogues of the Bim BH3 domain .
24838655	0	BH3	93,96	Bim	89,92	BH3	Bim	MESH:C006008	10018	Chemical	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	Two-face , two-turn a-helix mimetics based on a cross-acridine scaffold : analogues of the Bim BH3 domain .
9804769	0	BH3	60,63	Bok	39,42	BH3	Bok	MESH:C006008	666	Chemical	Gene	domain|compound|START_ENTITY END_ENTITY|nmod|domain	A splicing variant of the Bcl-2 member Bok with a truncated BH3 domain induces apoptosis but does not dimerize with antiapoptotic Bcl-2 proteins in vitro .
24850748	0	BH3	24,27	F1L	75,78	BH3	F1L	MESH:C006008	3707497(Tax:10245)	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Structural insight into BH3 domain binding of vaccinia_virus antiapoptotic F1L .
24865469	0	BH3	68,71	Mcl-1	62,67	BH3	Mcl-1	MESH:C006008	4170	Chemical	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	Molecular dynamics study of segment peptides of Bax , Bim , and Mcl-1 BH3 domain of the apoptosis-regulating proteins bound to the anti-apoptotic Mcl-1 protein .
21393385	0	BH3	29,32	bad	84,87	BH3	bad	MESH:C006008	572	Chemical	Gene	domain|appos|START_ENTITY reveals|nsubj|domain reveals|dobj|regulation regulation|nmod|END_ENTITY	The Bcl-2 homology domain 3 -LRB- BH3 -RRB- mimetic ABT-737 reveals the dynamic regulation of bad , a proapoptotic protein of the Bcl-2 family , by Bcl-xL .
21810274	0	BH3	81,84	bax	65,68	BH3	bax	MESH:C006008	581	Chemical	Gene	domain|compound|START_ENTITY binds|nmod|domain binds|nmod|END_ENTITY	The matrix -LRB- M -RRB- protein of Newcastle_disease virus binds to human bax through its BH3 domain .
19180116	0	BH3	43,46	beclin_1	57,65	BH3	beclin 1	MESH:C006008	8678	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	DAP-kinase-mediated phosphorylation on the BH3 domain of beclin_1 promotes dissociation of beclin_1 from Bcl-XL and induction of autophagy .
19180116	0	BH3	43,46	beclin_1	91,99	BH3	beclin 1	MESH:C006008	8678	Chemical	Gene	domain|compound|START_ENTITY phosphorylation|nmod|domain promotes|nsubj|phosphorylation promotes|dobj|dissociation dissociation|nmod|END_ENTITY	DAP-kinase-mediated phosphorylation on the BH3 domain of beclin_1 promotes dissociation of beclin_1 from Bcl-XL and induction of autophagy .
21527247	0	BH3	26,29	clusterin	40,49	BH3	clusterin	MESH:C006008	1191	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Interaction of a putative BH3 domain of clusterin with anti-apoptotic Bcl-2 family proteins as revealed by NMR spectroscopy .
7716780	0	BHT	128,131	protein_kinase_C-alpha	32,54	BHT	protein kinase C-alpha	MESH:D002084	18750(Tax:10090)	Chemical	Gene	changes|appos|START_ENTITY changes|nmod|END_ENTITY	Very early changes in pulmonary protein_kinase_C-alpha and calpain_II_contents following injection of butylated_hydroxytoluene -LRB- BHT -RRB- into mice .
22804249	0	BI-38335	48,56	SGLT2	66,71	BI-38335	SGLT2	null	246787(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Effects of combining linagliptin treatment with BI-38335 , a novel SGLT2 inhibitor , on pancreatic islet function and inflammation in db/db mice .
10566233	0	BI-6	42,46	acetylcholinesterase	137,157	BI-6	acetylcholinesterase	MESH:C118647	83817(Tax:10116)	Chemical	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|END_ENTITY	-LSB- Comparison of the reactivating effect of BI-6 , a new asymmetrical bispyridinium_oxime , with oxime HI-6 and obidoxime on soman-inhibited acetylcholinesterase in the diaphragm and various parts of the brain in rats -RSB- .
21592316	0	BI-69A11	36,44	AKT	82,85	BI-69A11	AKT	MESH:C540767	207	Chemical	Gene	melanoma|nmod|START_ENTITY inhibition|nmod|melanoma mediated|nsubjpass|inhibition mediated|nmod|dual dual|nmod|pathways pathways|compound|END_ENTITY	Effective inhibition of melanoma by BI-69A11 is mediated by dual targeting of the AKT and NF-kB pathways .
24892445	0	BI-69A11	0,8	Akt	109,112	BI-69A11	Akt	MESH:C540767	207	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|growth growth|acl|inhibition inhibition|advcl|targeting targeting|dobj|END_ENTITY	BI-69A11 enhances susceptibility of colon_cancer cells to mda-7 / IL-24-induced growth inhibition by targeting Akt .
26306675	0	BI-69A11	57,65	Akt	75,78	BI-69A11	Akt	MESH:C540767	207	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Blockade of autophagy enhances proapoptotic potential of BI-69A11 , a novel Akt inhibitor , in colon_carcinoma .
25873592	0	BI-847325	54,63	BRAF	83,87	BI-847325	BRAF	null	673	Chemical	Gene	Inhibitor|compound|START_ENTITY Inhibitor|compound|END_ENTITY	The Novel ATP-Competitive MEK/Aurora Kinase Inhibitor BI-847325 Overcomes Acquired BRAF Inhibitor Resistance through Suppression of Mcl-1 and MEK Expression .
25889895	0	BI-D1870	32,40	RSK	16,19	BI-D1870	RSK	MESH:C516541	6196	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Two widely used RSK inhibitors , BI-D1870 and SL0101 , alter mTORC1 signaling in a RSK-independent manner .
1335586	0	BI-L-239	10,18	leukotriene_B4	42,56	BI-L-239	leukotriene B4	MESH:C067524	100135572(Tax:10141)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|synthesis synthesis|amod|END_ENTITY	Effect of BI-L-239 , A-64077 and MK-886 on leukotriene_B4 synthesis by chopped guinea_pig lung and on antigen-induced tracheal contraction in vitro .
12787259	0	BIA_3-202	69,78	Catechol-O-methyltransferase	0,28	BIA 3-202	Catechol-O-methyltransferase	MESH:C433466	24267(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Catechol-O-methyltransferase inhibition in erythrocytes and liver by BIA_3-202 -LRB- 1 - -LSB- 3,4-dibydroxy-5-nitrophenyl -RSB- -2 - phenyl-ethanone -RRB- .
12559377	0	BIA_3-202	30,39	catechol-O-methyltransferase	96,124	BIA 3-202	catechol-O-methyltransferase	MESH:C433466	24267(Tax:10116)	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Kinetic inhibitory profile of BIA_3-202 , a novel fast tight-binding , reversible and competitive catechol-O-methyltransferase inhibitor .
12660477	0	BIA_3-202	0,9	catechol-O-methyltransferase	19,47	BIA 3-202	catechol-O-methyltransferase	MESH:C433466	24267(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	BIA_3-202 , a novel catechol-O-methyltransferase inhibitor , reduces the peripheral O-methylation of L-DOPA and enhances its availability to the brain .
16790555	0	BIA_3-202	32,41	catechol-o-methyltransferase	52,80	BIA 3-202	catechol-o-methyltransferase	MESH:C433466	1312	Chemical	Gene	nebicapone|appos|START_ENTITY nebicapone|appos|inhibitor inhibitor|amod|END_ENTITY	Human metabolism of nebicapone -LRB- BIA_3-202 -RRB- , a novel catechol-o-methyltransferase inhibitor : characterization of in vitro glucuronidation .
24924525	0	BIBF_1120	23,32	VEGFR	57,62	BIBF 1120	VEGFR	MESH:C530716	3791	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	What could Nintedanib -LRB- BIBF_1120 -RRB- , a triple inhibitor of VEGFR , PDGFR , and FGFR , add to the current treatment options for patients with metastatic colorectal_cancer ?
10711339	0	BIBN4096BS	27,37	CGRP	74,78	BIBN4096BS	CGRP	MESH:C406305	796	Chemical	Gene	profile|nmod|START_ENTITY END_ENTITY|nsubj|profile	Pharmacological profile of BIBN4096BS , the first selective small molecule CGRP antagonist .
11755165	0	BIBN4096BS	39,49	CGRP	14,18	BIBN4096BS	CGRP	MESH:C406305	796	Chemical	Gene	antagonist|dobj|START_ENTITY antagonist|nsubj|Effect Effect|nmod|receptor receptor|compound|END_ENTITY	Effect of the CGRP receptor antagonist BIBN4096BS in human cerebral , coronary and omental arteries and in SK-N-MC cells .
11976276	0	BIBN4096BS	0,10	CGRP	126,130	BIBN4096BS	CGRP	MESH:C406305	796	Chemical	Gene	antagonist|nsubj|START_ENTITY antagonist|nmod|effects effects|nmod|alpha-CGRP alpha-CGRP|dep|comparison comparison|nmod|END_ENTITY	BIBN4096BS is a potent competitive antagonist of the relaxant effects of alpha-CGRP on human temporal artery : comparison with CGRP -LRB- 8-37 -RRB- .
12183333	0	BIBN4096BS	31,41	CGRP	60,64	BIBN4096BS	CGRP	MESH:C406305	796	Chemical	Gene	actions|nmod|START_ENTITY comparison|nmod|actions comparison|nmod|receptors receptors|compound|END_ENTITY	A comparison of the actions of BIBN4096BS and CGRP -LRB- 8-37 -RRB- on CGRP and adrenomedullin receptors expressed on SK-N-MC , L6 , Col 29 and Rat_2 cells .
12970078	0	BIBN4096BS	40,50	CGRP	15,19	BIBN4096BS	CGRP	MESH:C406305	100124407(Tax:9823)	Chemical	Gene	antagonist|dobj|START_ENTITY antagonist|nsubj|Effects Effects|nmod|receptor receptor|compound|END_ENTITY	Effects of the CGRP receptor antagonist BIBN4096BS on capsaicin-induced carotid haemodynamic changes in anaesthetised pigs .
15228501	0	BIBN4096BS	74,84	CGRP	48,52	BIBN4096BS	CGRP	MESH:C406305	24241(Tax:10116)	Chemical	Gene	antagonist|dobj|START_ENTITY antagonist|nsubj|Effects Effects|nmod|receptor receptor|appos|END_ENTITY	Effects of the calcitonin_gene-related_peptide -LRB- CGRP -RRB- receptor antagonist BIBN4096BS on alpha-CGRP-induced regional haemodynamic changes in anaesthetised rats .
15237099	0	BIBN4096BS	63,73	CGRP	37,41	BIBN4096BS	CGRP	MESH:C406305	12310(Tax:10090)	Chemical	Gene	blocks|compound|START_ENTITY blocks|appos|END_ENTITY	The calcitonin_gene-related_peptide -LRB- CGRP -RRB- receptor antagonist BIBN4096BS blocks CGRP and adrenomedullin vasoactive responses in the microvasculature .
15237099	0	BIBN4096BS	63,73	CGRP	81,85	BIBN4096BS	CGRP	MESH:C406305	12310(Tax:10090)	Chemical	Gene	blocks|compound|START_ENTITY blocks|amod|END_ENTITY	The calcitonin_gene-related_peptide -LRB- CGRP -RRB- receptor antagonist BIBN4096BS blocks CGRP and adrenomedullin vasoactive responses in the microvasculature .
15504760	0	BIBN4096BS	21,31	CGRP	70,74	BIBN4096BS	CGRP	MESH:C406305	24241(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY induced|nsubj|effect induced|nmod|END_ENTITY	Inhibitory effect of BIBN4096BS on cephalic vasodilatation induced by CGRP or transcranial electrical stimulation in the rat .
15867946	0	BIBN4096BS	32,42	CGRP	46,50	BIBN4096BS	CGRP	MESH:C406305	796	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	The preclinical pharmacology of BIBN4096BS , a CGRP antagonist .
17349622	0	BIBN4096BS	63,73	CGRP	37,41	BIBN4096BS	CGRP	MESH:C406305	24241(Tax:10116)	Chemical	Gene	START_ENTITY|amod|calcitonin_gene-related_peptide calcitonin_gene-related_peptide|dep|END_ENTITY	The calcitonin_gene-related_peptide -LRB- CGRP -RRB- receptor antagonist BIBN4096BS reduces neurogenic increases in dural blood flow .
19914210	0	BIBN4096BS	47,57	CGRP	32,36	BIBN4096BS	CGRP	MESH:C406305	796	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|nmod|receptor receptor|compound|END_ENTITY	Non-peptidic antagonists of the CGRP receptor , BIBN4096BS and MK-0974 , interact with the calcitonin_receptor-like_receptor via methionine-42 and RAMP1 via tryptophan-74 .
20959429	0	BIBN4096BS	37,47	CGRP	0,4	BIBN4096BS	CGRP	MESH:C406305	796	Chemical	Gene	olcegepant|appos|START_ENTITY olcegepant|compound|END_ENTITY	CGRP receptor antagonist olcegepant -LRB- BIBN4096BS -RRB- does not prevent glyceryl_trinitrate-induced migraine .
24794104	0	BIBN4096BS	35,45	CGRP	56,60	BIBN4096BS	CGRP	MESH:C406305	796	Chemical	Gene	product|nmod|START_ENTITY product|dep|antagonist antagonist|compound|END_ENTITY	Serendipitous oxidation product of BIBN4096BS : a potent CGRP receptor antagonist .
25929169	0	BIBN4096BS	35,45	CGRP	10,14	BIBN4096BS	CGRP	MESH:C406305	12310(Tax:10090)	Chemical	Gene	alleviates|nsubj|START_ENTITY END_ENTITY|ccomp|alleviates	The novel CGRP receptor antagonist BIBN4096BS alleviates a postoperative intestinal inflammation and prevents postoperative_ileus .
15237099	0	BIBN4096BS	63,73	calcitonin_gene-related_peptide	4,35	BIBN4096BS	calcitonin gene-related peptide	MESH:C406305	12310(Tax:10090)	Chemical	Gene	blocks|compound|START_ENTITY blocks|amod|END_ENTITY	The calcitonin_gene-related_peptide -LRB- CGRP -RRB- receptor antagonist BIBN4096BS blocks CGRP and adrenomedullin vasoactive responses in the microvasculature .
10576563	0	BIBP_3226	43,52	neuropeptide_Y	16,30	BIBP 3226	neuropeptide Y	null	24604(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	The effect of a neuropeptide_Y antagonist , BIBP_3226 , on short-term arterial pressure control in conscious unrestrained rats with congestive heart_failure .
8970769	0	BIBR-277	11,19	angiotensin_II_type_1_receptor	24,54	BIBR-277	angiotensin II type 1 receptor	MESH:C084178	403836(Tax:9615)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Effects of BIBR-277 , an angiotensin_II_type_1_receptor antagonist , on stunned_myocardium in dogs .
8021462	0	BIBR277	106,113	angiotensin_II	80,94	BIBR277	angiotensin II	MESH:C084178	24179(Tax:10116)	Chemical	Gene	antagonist|dobj|START_ENTITY antagonist|nsubj|END_ENTITY	Effects on binding characteristics and renal function of the novel , non-peptide angiotensin_II antagonist BIBR277 in the rat .
22236190	0	BIBR_1532	39,48	p21	108,111	BIBR 1532	p21	MESH:C458523	644914	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Direct short-term cytotoxic effects of BIBR_1532 on acute_promyelocytic_leukemia cells through induction of p21 coupled with downregulation of c-Myc and hTERT transcription .
8220885	0	BIBR_277	93,101	angiotensin_II	57,71	BIBR 277	angiotensin II	MESH:C084178	24179(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Pharmacological characterization of the novel nonpeptide angiotensin_II receptor antagonist , BIBR_277 .
18026190	0	BIBW_2992	35,44	EGFR	116,120	BIBW 2992	EGFR	MESH:C522924	1956	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	A phase I dose escalation study of BIBW_2992 , an irreversible dual inhibitor of epidermal growth factor receptor 1 -LRB- EGFR -RRB- and 2 -LRB- HER2 -RRB- tyrosine kinase in a 2-week on , 2-week off schedule in patients with advanced solid tumours .
20574858	0	BIBW_2992	118,127	EGFR	0,4	BIBW 2992	EGFR	MESH:C522924	1956	Chemical	Gene	role|nmod|START_ENTITY inhibitors|dep|role inhibitors|amod|END_ENTITY	EGFR inhibitors in non-small cell lung_cancer -LRB- NSCLC -RRB- : the emerging role of the dual irreversible EGFR/HER2 inhibitor BIBW_2992 .
20679611	0	BIBW_2992	65,74	EGFR	34,38	BIBW 2992	EGFR	MESH:C522924	1956	Chemical	Gene	kinase|dobj|START_ENTITY kinase|nsubj|trial trial|nmod|END_ENTITY	Phase I trial of the irreversible EGFR and HER2 kinase inhibitor BIBW_2992 in patients with advanced solid tumors .
18026190	0	BIBW_2992	35,44	HER2	129,133	BIBW 2992	HER2	MESH:C522924	2064	Chemical	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	A phase I dose escalation study of BIBW_2992 , an irreversible dual inhibitor of epidermal growth factor receptor 1 -LRB- EGFR -RRB- and 2 -LRB- HER2 -RRB- tyrosine kinase in a 2-week on , 2-week off schedule in patients with advanced solid tumours .
19372565	0	BIIB021	0,7	Hsp90	97,102	BIIB021	Hsp90	MESH:C521963	3320	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	BIIB021 , an orally available , fully synthetic small-molecule inhibitor of the heat_shock protein Hsp90 .
19662650	0	BIIB021	0,7	Hsp90	17,22	BIIB021	Hsp90	MESH:C521963	3320	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	BIIB021 , a novel Hsp90 inhibitor , sensitizes head_and_neck_squamous_cell_carcinoma to radiotherapy .
19676042	0	BIIB021	0,7	Hsp90	21,26	BIIB021	Hsp90	MESH:C521963	3320	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	BIIB021 , a synthetic Hsp90 inhibitor , has broad application against tumors with acquired multidrug resistance .
24926340	0	BIIB021	0,7	Hsp90	12,17	BIIB021	Hsp90	MESH:C521963	3320	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	BIIB021 , an Hsp90 inhibitor , effectively kills a myelodysplastic_syndrome cell line via the activation of caspases and inhibition of PI3K/Akt and NF-kB pathway proteins .
25223594	0	BIIB021	0,7	Hsp90	17,22	BIIB021	Hsp90	MESH:C521963	3320	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	BIIB021 , a novel Hsp90 inhibitor , sensitizes esophageal_squamous_cell_carcinoma to radiation .
26892093	0	BIIB021	17,24	Hsp90	0,5	BIIB021	Hsp90	MESH:C521963	3320	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Hsp90 inhibitor , BIIB021 , induces apoptosis and autophagy by regulating mTOR-Ulk1 pathway in imatinib-sensitive and - resistant chronic_myeloid_leukemia cells .
27058144	0	BIIB021	0,7	Hsp90	21,26	BIIB021	Hsp90	MESH:C521963	3320	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	BIIB021 , a synthetic Hsp90 inhibitor , induces mutant ataxin-1 degradation through the activation of heat_shock factor 1 .
19671844	0	BIIB021	32,39	NF-kappaB	59,68	BIIB021	NF-kappaB	MESH:C521963	4790	Chemical	Gene	depletes|nsubj|START_ENTITY depletes|dobj|END_ENTITY	Heat_shock_protein_90 inhibitor BIIB021 -LRB- CNF2024 -RRB- depletes NF-kappaB and sensitizes Hodgkin 's _ lymphoma cells for natural killer cell-mediated cytotoxicity .
27058144	0	BIIB021	0,7	ataxin-1	53,61	BIIB021	ataxin-1	MESH:C521963	6310	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|degradation degradation|amod|END_ENTITY	BIIB021 , a synthetic Hsp90 inhibitor , induces mutant ataxin-1 degradation through the activation of heat_shock factor 1 .
14722206	0	BIIL_284	70,78	Mac-1	49,54	BIIL 284	Mac-1	MESH:C424425	3684	Chemical	Gene	expression|nmod|START_ENTITY expression|nsubj|Inhibition Inhibition|appos|END_ENTITY	Inhibition of leukotriene_B4-induced CD11B/CD18 -LRB- Mac-1 -RRB- expression by BIIL_284 , a new long acting LTB4 receptor antagonist , in patients with rheumatoid_arthritis .
24074954	0	BIM	39,42	BAX	68,71	BIM	BAX	CHEBI:33173	581	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	BID preferentially activates BAK while BIM preferentially activates BAX , affecting chemotherapy response .
1815620	0	BIM-18216	10,19	cholecystokinin	102,117	BIM-18216	cholecystokinin	MESH:C074760	25298(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY induced|nsubj|Effect induced|nmod|END_ENTITY	Effect of BIM-18216 , a novel cholecystokinin receptor antagonist , on food intake reduction induced by cholecystokinin .
1815620	0	BIM-18216	10,19	cholecystokinin	29,44	BIM-18216	cholecystokinin	MESH:C074760	25298(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Effect of BIM-18216 , a novel cholecystokinin receptor antagonist , on food intake reduction induced by cholecystokinin .
12770925	0	BIM-23127	38,47	neuromedin_B_receptor	4,25	BIM-23127	neuromedin B receptor	MESH:C092829	4829	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	The neuromedin_B_receptor antagonist , BIM-23127 , is a potent antagonist at human and rat urotensin-II receptors .
10080163	0	BIM-43073D	64,74	peptide_YY	44,54	BIM-43073D	peptide YY	MESH:C118143	607156(Tax:9615)	Chemical	Gene	analogs|amod|START_ENTITY analogs|amod|END_ENTITY	Characterization of two novel proabsorptive peptide_YY analogs , BIM-43073D and BIM-43004C .
9383271	0	BIM-44002	29,38	PTH	14,17	BIM-44002	PTH	MESH:C095805	5741	Chemical	Gene	antagonist|dobj|START_ENTITY antagonist|nsubj|effect effect|nmod|END_ENTITY	The effect of PTH antagonist BIM-44002 on serum calcium and PTH levels in hypercalcemic hyperparathyroid patients .
2229420	0	BIM_21009	110,119	luteinizing_hormone-releasing_hormone	60,97	BIM 21009	luteinizing hormone-releasing hormone	MESH:C055689	25194(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Validation in rat plasma of a direct radioimmunoassay for a luteinizing_hormone-releasing_hormone antagonist -LRB- BIM_21009 -RRB- Rabbits were immunized with -LSB- Ac-D-beta-Nal1 - , _ D-p-Cl-Phe2 , D-Phe3 , D-Arg6 , Phe7 , D-Ala10 -RSB- LHRH -LRB- BIM_21009 -RRB- coupled to bovine serum albumin using bis-diazotized_benzidine .
2229420	0	BIM_21009	216,225	luteinizing_hormone-releasing_hormone	60,97	BIM 21009	luteinizing hormone-releasing hormone	MESH:C055689	25194(Tax:10116)	Chemical	Gene	_|dep|START_ENTITY _|nsubj|Validation Validation|nmod|plasma plasma|nmod|radioimmunoassay radioimmunoassay|nmod|antagonist antagonist|amod|END_ENTITY	Validation in rat plasma of a direct radioimmunoassay for a luteinizing_hormone-releasing_hormone antagonist -LRB- BIM_21009 -RRB- Rabbits were immunized with -LSB- Ac-D-beta-Nal1 - , _ D-p-Cl-Phe2 , D-Phe3 , D-Arg6 , Phe7 , D-Ala10 -RSB- LHRH -LRB- BIM_21009 -RRB- coupled to bovine serum albumin using bis-diazotized_benzidine .
1340687	0	BIM_23014	55,64	growth_hormone	68,82	BIM 23014	growth hormone	MESH:C060347	2688	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	-LSB- Influence of dose and modalities of administration of BIM_23014 on growth_hormone secretion in patients with acromegaly -RSB- .
2563730	0	BIM_23014	35,44	growth_hormone	65,79	BIM 23014	growth hormone	MESH:C060347	2688	Chemical	Gene	START_ENTITY|nmod|secretion secretion|nmod|thyrotropin thyrotropin|compound|END_ENTITY	Effects of the somatostatin analog BIM_23014 on the secretion of growth_hormone , thyrotropin , and digestive peptides in normal men .
8405033	0	BIM_23014	117,126	growth_hormone	37,51	BIM 23014	growth hormone	MESH:C060347	2688	Chemical	Gene	study|nmod|START_ENTITY study|nmod|secretion secretion|amod|END_ENTITY	Pharmacokinetic study and effects on growth_hormone secretion in healthy volunteers of the new somatostatin analogue BIM_23014 .
2748916	0	BIM_23014	135,144	platelet-activating_factor	55,81	BIM 23014	platelet-activating factor	MESH:C060347	300795(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY rat|dep|antagonist rat|nmod|END_ENTITY	Modulation of eosinophil recruitment in the rat by the platelet-activating_factor -LRB- PAF -RRB- antagonist , BN_52021 , the somatostatin analog , BIM_23014 , and by cyclosporin_A .
9650851	0	BIM_26226	51,60	gastrin-releasing_peptide	14,39	BIM 26226	gastrin-releasing peptide	MESH:C091872	171101(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|antagonist antagonist|amod|END_ENTITY	Effect of the gastrin-releasing_peptide antagonist BIM_26226 and lanreotide on an acinar pancreatic_carcinoma .
21328587	0	BIRB-796	51,59	p38	78,81	BIRB-796	p38	MESH:C452139	1432	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	A possible mechanism for hepatotoxicity induced by BIRB-796 , an orally active p38 mitogen-activated protein kinase inhibitor .
20655210	0	BIRB796	70,77	JNK2	27,31	BIRB796	JNK2	MESH:C452139	5601	Chemical	Gene	complexed|nmod|START_ENTITY END_ENTITY|acl|complexed	X-ray crystal structure of JNK2 complexed with the p38alpha inhibitor BIRB796 : insights into the rational design of DFG-out binding MAP kinase inhibitors .
23349819	0	BIRB796	0,7	p38	26,29	BIRB796	p38	MESH:C452139	26416(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|kinase kinase|amod|END_ENTITY	BIRB796 , the inhibitor of p38 mitogen-activated protein kinase , enhances the efficacy of chemotherapeutic agents in ABCB1 overexpression cells .
16527696	0	BIRB_796	58,66	p38_mitogen-activated_protein_kinase	5,41	BIRB 796	p38 mitogen-activated protein kinase	MESH:C452139	1432	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Oral p38_mitogen-activated_protein_kinase inhibition with BIRB_796 for active Crohn 's _ disease : a randomized , double-blind , placebo-controlled trial .
27048659	0	BI_1002494	0,10	SYK	46,49	BI 1002494	SYK	null	6850	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	BI_1002494 , a novel potent and selective oral SYK inhibitor displays differential potency in human basophils and B-cells .
23962445	0	BI_2536	61,68	ABCB1	6,11	BI 2536	ABCB1	MESH:C518477	5243	Chemical	Gene	mediate|nmod|START_ENTITY mediate|nsubj|END_ENTITY	Human ABCB1 -LRB- P-glycoprotein -RRB- and ABCG2 mediate resistance to BI_2536 , a potent and selective inhibitor of Polo-like_kinase_1 .
22527426	0	BI_2536	28,35	PLK1	9,13	BI 2536	PLK1	MESH:C518477	5347	Chemical	Gene	inhibition|nmod|START_ENTITY decreases|nsubj|inhibition decreases|nmod|END_ENTITY	In vitro PLK1 inhibition by BI_2536 decreases proliferation and induces cell-cycle arrest in melanoma cells .
20526206	0	BI_2536	27,34	Plk-1	44,49	BI 2536	Plk-1	MESH:C518477	5347	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	The efficacy and safety of BI_2536 , a novel Plk-1 inhibitor , in patients with stage IIIB/IV non-small_cell_lung_cancer who had relapsed after , or failed , chemotherapy : results from an open-label , randomized phase II clinical trial .
21516508	0	BI_2536	101,108	Plk-1	111,116	BI 2536	Plk-1	MESH:C518477	5347	Chemical	Gene	START_ENTITY|dobj|inhibitor inhibitor|compound|END_ENTITY	Comparison of different semi-mechanistic models for chemotherapy-related neutropenia : application to BI_2536 a Plk-1 inhibitor .
20072841	0	BI_2536	0,7	Plk1	58,62	BI_2536	Plk1	MESH:C518477	5347	Chemical	Gene	START_ENTITY|parataxis|targeting targeting|dobj|Polo-like_kinase_1 Polo-like_kinase_1|appos|END_ENTITY	BI_2536 -- targeting the mitotic kinase Polo-like_kinase_1 -LRB- Plk1 -RRB- .
20145140	0	BI_2536	133,140	Plk1	20,24	BI 2536	Plk1	MESH:C518477	5347	Chemical	Gene	resistance|nmod|START_ENTITY Polo-like_kinase_1|dep|resistance Polo-like_kinase_1|appos|END_ENTITY	Polo-like_kinase_1 -LRB- Plk1 -RRB- as a novel drug target in chronic_myeloid_leukemia : overriding imatinib resistance with the Plk1 inhibitor BI_2536 .
20927084	0	BI_2536	97,104	Plk1	108,112	BI 2536	Plk1	MESH:C518477	5347	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Prediction of neutropenia-related effects of a new combination therapy with the anticancer drugs BI_2536 -LRB- a Plk1 inhibitor -RRB- and pemetrexed .
18955456	0	BI_2536	53,60	Polo-like_kinase_1	70,88	BI 2536	Polo-like kinase 1	MESH:C518477	5347	Chemical	Gene	escalation|nmod|START_ENTITY escalation|appos|inhibitor inhibitor|compound|END_ENTITY	Phase I dose escalation and pharmacokinetic study of BI_2536 , a novel Polo-like_kinase_1 inhibitor , in patients with advanced solid tumors .
20072841	0	BI_2536	0,7	Polo-like_kinase_1	38,56	BI_2536	Polo-like kinase 1	MESH:C518477	5347	Chemical	Gene	START_ENTITY|parataxis|targeting targeting|dobj|END_ENTITY	BI_2536 -- targeting the mitotic kinase Polo-like_kinase_1 -LRB- Plk1 -RRB- .
20145140	0	BI_2536	133,140	Polo-like_kinase_1	0,18	BI 2536	Polo-like kinase 1	MESH:C518477	5347	Chemical	Gene	resistance|nmod|START_ENTITY END_ENTITY|dep|resistance	Polo-like_kinase_1 -LRB- Plk1 -RRB- as a novel drug target in chronic_myeloid_leukemia : overriding imatinib resistance with the Plk1 inhibitor BI_2536 .
23962445	0	BI_2536	61,68	Polo-like_kinase_1	106,124	BI 2536	Polo-like kinase 1	MESH:C518477	5347	Chemical	Gene	mediate|nmod|START_ENTITY mediate|dobj|inhibitor inhibitor|nmod|END_ENTITY	Human ABCB1 -LRB- P-glycoprotein -RRB- and ABCG2 mediate resistance to BI_2536 , a potent and selective inhibitor of Polo-like_kinase_1 .
17291758	0	BI_2536	0,7	polo-like_kinase_1	45,63	BI 2536	polo-like kinase 1	MESH:C518477	5347	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	BI_2536 , a potent and selective inhibitor of polo-like_kinase_1 , inhibits tumor growth in vivo .
17291761	0	BI_2536	29,36	polo-like_kinase_1	82,100	BI 2536	polo-like kinase 1	MESH:C518477	5347	Chemical	Gene	reveals|nsubj|START_ENTITY reveals|nmod|roles roles|nmod|END_ENTITY	The small-molecule inhibitor BI_2536 reveals novel insights into mitotic roles of polo-like_kinase_1 .
26412161	0	BI_6727	79,86	Polo-like_Kinase_1	114,132	BI 6727	Polo-like Kinase 1	MESH:C541363	5347	Chemical	Gene	Volasertib|appos|START_ENTITY Volasertib|appos|Inhibitor Inhibitor|nmod|END_ENTITY	Human ATP-Binding Cassette Transporter ABCB1 Confers Resistance to Volasertib -LRB- BI_6727 -RRB- , a Selective Inhibitor of Polo-like_Kinase_1 .
24884503	0	BI_6727	121,128	polo-like_kinase_1	58,76	BI 6727	polo-like kinase 1	MESH:C541363	5347	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Large-scale label-free comparative proteomics analysis of polo-like_kinase_1 inhibition via the small-molecule inhibitor BI_6727 -LRB- Volasertib -RRB- in BRAF -LRB- V600E -RRB- mutant melanoma cells .
25529193	0	BI_831266	35,44	Aurora_kinase_B	62,77	BI 831266	Aurora kinase B	null	9212	Chemical	Gene	study|nmod|START_ENTITY study|appos|inhibitor inhibitor|nmod|END_ENTITY	A phase 1 dose escalation study of BI_831266 , an inhibitor of Aurora_kinase_B , in patients with advanced solid tumors .
21620825	0	BJ-B11	0,6	Hsp90	16,21	BJ-B11	Hsp90	MESH:C559135	3320	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	BJ-B11 , a novel Hsp90 inhibitor , induces apoptosis in human chronic_myeloid_leukemia K562 cells through the mitochondria-dependent pathway .
26846842	0	BKM-120	0,7	Phosphatidyl-Inositol-3_Kinase	24,54	BKM-120	Phosphatidyl-Inositol-3 Kinase	MESH:C571178	5293	Chemical	Gene	START_ENTITY|dep|Inhibitor Inhibitor|compound|END_ENTITY	BKM-120 -LRB- Buparlisib -RRB- : A Phosphatidyl-Inositol-3_Kinase Inhibitor with Anti-Invasive Properties in Glioblastoma .
22925564	0	BKT140	62,68	CXCR4	45,50	BKT140	CXCR4	MESH:C577220	7852	Chemical	Gene	antagonist|dobj|START_ENTITY antagonist|nsubj|efficacy efficacy|nmod|END_ENTITY	In vitro and in vivo therapeutic efficacy of CXCR4 antagonist BKT140 against human non-small_cell_lung_cancer .
9469639	0	BL-2401	52,59	enkephalinase	69,82	BL-2401	enkephalinase	MESH:C110981	17380(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Antinociceptive and antidepressant-like profiles of BL-2401 , a novel enkephalinase inhibitor , in mice and rats .
25542230	0	BM-1197	28,35	Bcl-2	74,79	BM-1197	Bcl-2	null	596	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	The small-molecule compound BM-1197 inhibits the antiapoptotic regulators Bcl-2 / Bcl-xL and triggers apoptotic cell death in human colorectal_cancer cells .
22024828	0	BM212	70,75	MmpL3	0,5	BM212	MmpL3	MESH:C115651	886752(Tax:83332)	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212 .
14612537	0	BMI-1026	65,73	cyclin-dependent_kinase_1	28,53	BMI-1026	cyclin-dependent kinase 1	MESH:C480542	12534(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Characterization of a novel cyclin-dependent_kinase_1 inhibitor , BMI-1026 .
24225006	0	BML-111	101,108	lipoxin_A4_receptor	72,91	BML-111	lipoxin A4 receptor	MESH:C530770	681706(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Neurovascular protection by post-ischemic intravenous injections of the lipoxin_A4_receptor agonist , BML-111 , in a rat model of ischemic_stroke .
23076030	0	BML-275	0,7	AMPK	12,16	BML-275	AMPK	MESH:C579800	5563	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	BML-275 , an AMPK inhibitor , induces DNA damage , G2/M arrest and apoptosis in human pancreatic_cancer cells .
23881923	0	BMN_673	0,7	PARP1/2	35,42	BMN 673	PARP1/2	null	64761;142;10038	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	BMN_673 , a novel and highly potent PARP1/2 inhibitor for the treatment of human cancers with DNA_repair_deficiency .
9721025	0	BMS-181885	0,10	5-HT1B	14,20	BMS-181885	5-HT1B	MESH:C111853	3351	Chemical	Gene	START_ENTITY|appos|receptor receptor|nummod|END_ENTITY	BMS-181885 , a 5-HT1B / 1D receptor ligand , in experimental models predictive of antimigraine activity and coronary side-effect potential .
15929069	0	BMS-347070	50,60	COX-2	33,38	BMS-347070	COX-2	MESH:C504079	4513	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Bioavailability enhancement of a COX-2 inhibitor , BMS-347070 , from a nanocrystalline_dispersion prepared by spray-drying .
17218385	0	BMS-354	88,95	Bcr/Abl	28,35	BMS-354	Bcr/Abl	null	25;613	Chemical	Gene	+|nmod|START_ENTITY +|nsubj|END_ENTITY	MEK1/2 inhibitors sensitize Bcr/Abl + human leukemia cells to the dual Abl/Src inhibitor BMS-354 / 825 .
15338193	0	BMS-387032	54,64	cyclin-dependent_kinase_2	75,100	BMS-387032	cyclin-dependent kinase 2	MESH:C484864	362817(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	P-glycoprotein plays a role in the oral absorption of BMS-387032 , a potent cyclin-dependent_kinase_2 inhibitor , in rats .
19789352	0	BMS-536924	158,168	insulin_receptor_isoform_A_and_insulin-like_growth_factor-1_receptor	14,82	BMS-536924	insulin receptor isoform A and insulin-like growth factor-1 receptor	MESH:C504983	3480	Chemical	Gene	effect|nmod|START_ENTITY Expression|dep|effect Expression|nmod|END_ENTITY	Expression of insulin_receptor_isoform_A_and_insulin-like_growth_factor-1_receptor in human acute_myelogenous_leukemia : effect of the dual-receptor inhibitor BMS-536924 in vitro .
16715389	0	BMS-561389	97,107	factor_Xa	76,85	BMS-561389	factor Xa	MESH:C500057	2159	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Formulation of solid dosage forms to overcome gastric pH interaction of the factor_Xa inhibitor , BMS-561389 .
23578688	0	BMS-582949	66,76	p38a	89,93	BMS-582949	p38a	MESH:C552704	1432	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Synthesis and evaluation of carbamoylmethylene linked prodrugs of BMS-582949 , a clinical p38a inhibitor .
25401969	0	BMS-626529	50,60	gp120	70,75	BMS-626529	gp120	MESH:C584152	155971(Tax:11676)	Chemical	Gene	START_ENTITY|acl|bound bound|nmod|END_ENTITY	Homology models of the HIV-1 attachment inhibitor BMS-626529 bound to gp120 suggest a unique mechanism of action .
23490650	0	BMS-690514	21,31	EGFR	36,40	BMS-690514	EGFR	MESH:C552150	1956	Chemical	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Phase I-IIa study of BMS-690514 , an EGFR , HER-2_and _ -4 and VEGFR-1 to -3 oral tyrosine kinase inhibitor , in patients with advanced or metastatic solid tumours .
21673131	0	BMS-690514	110,120	cytochrome_P450	56,71	BMS-690514	cytochrome P450	MESH:C552150	4051	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	In vitro characterization of the metabolic pathways and cytochrome_P450 inhibition and induction potential of BMS-690514 , an ErbB/vascular endothelial growth factor receptor inhibitor .
22042792	0	BMS-754807	27,37	IGF-1R	5,11	BMS-754807	IGF-1R	MESH:C545990	3480	Chemical	Gene	synergizes|nsubj|START_ENTITY END_ENTITY|parataxis|synergizes	Dual IGF-1R / InsR inhibitor BMS-754807 synergizes with hormonal agents in treatment of estrogen-dependent breast_cancer .
25101488	0	BMS-817399	34,44	CCR1	17,21	BMS-817399	CCR1	null	1230	Chemical	Gene	Antagonist|appos|START_ENTITY Antagonist|compound|END_ENTITY	Discovery of the CCR1 Antagonist , BMS-817399 , for the Treatment of Rheumatoid_Arthritis .
25476894	0	BMS-908662	24,34	RAF	51,54	BMS-908662	RAF	null	22882	Chemical	Gene	study|appos|START_ENTITY study|appos|inhibitor inhibitor|compound|END_ENTITY	Phase I study of XL281 -LRB- BMS-908662 -RRB- , a potent oral RAF kinase inhibitor , in patients with advanced solid tumors .
22015772	0	BMS-911543	20,30	JAK2	85,89	BMS-911543	JAK2	MESH:C571029	3717	Chemical	Gene	Characterization|nmod|START_ENTITY Characterization|appos|inhibitor inhibitor|nmod|END_ENTITY	Characterization of BMS-911543 , a functionally selective small-molecule inhibitor of JAK2 .
25930207	0	BMS-911543	59,69	JAK2	73,77	BMS-911543	JAK2	MESH:C571029	3717	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	A UHPLC-MS/MS bioanalytical assay for the determination of BMS-911543 , a JAK2 inhibitor , in human plasma .
26288683	0	BMS-911543	48,58	JAK2	32,36	BMS-911543	JAK2	MESH:C571029	3717	Chemical	Gene	Discovery|appos|START_ENTITY Discovery|nmod|Inhibitor Inhibitor|compound|END_ENTITY	Discovery of a Highly Selective JAK2 Inhibitor , BMS-911543 , for the Treatment_of_Myeloproliferative_Neoplasms .
26576779	0	BMS-936561	44,54	CD70	104,108	BMS-936561	CD70	null	970	Chemical	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	First-in-human multicenter phase I study of BMS-936561 -LRB- MDX-1203 -RRB- , an antibody-drug conjugate targeting CD70 .
11448563	0	BMS284756	12,21	T-3811	23,29	BMS284756	T-3811	MESH:C419689	1071339(Tax:209261)	Chemical	Gene	Activity|nmod|START_ENTITY Activity|appos|END_ENTITY	Activity of BMS284756 -LRB- T-3811 -RRB- tested against anaerobic bacteria , Campylobacter_jejuni , Helicobacter_pylori and Legionella spp .
22952994	0	BMS309403	0,9	AMP-activated_protein_kinase	70,98	BMS309403	AMP-activated protein kinase	MESH:C559288	5563	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|activation activation|nmod|END_ENTITY	BMS309403 stimulates glucose uptake in myotubes through activation of AMP-activated_protein_kinase .
1970304	0	BMY_7378	99,107	5-HT1A	80,86	BMY 7378	5-HT1A	MESH:C053428	24473(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Further investigation of the in vivo pharmacological properties of the putative 5-HT1A antagonist , BMY_7378 .
10380411	0	BM_144	0,6	thromboxane_A2_receptor	20,43	BM 144	thromboxane A2 receptor	MESH:C120544	6915	Chemical	Gene	START_ENTITY|dep|antagonist antagonist|amod|END_ENTITY	BM_144 : an original thromboxane_A2_receptor antagonist derived from torasemide .
9500121	0	BN-50730	11,19	AChE	65,69	BN-50730	AChE	MESH:C066686	11423(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Effects of BN-50730 -LRB- PAF_receptor antagonist -RRB- and physostigmine -LRB- AChE inhibitor -RRB- on learning and memory in mice .
9500121	0	BN-50730	11,19	PAF_receptor	21,33	BN-50730	PAF receptor	MESH:C066686	19204(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Effects of BN-50730 -LRB- PAF_receptor antagonist -RRB- and physostigmine -LRB- AChE inhibitor -RRB- on learning and memory in mice .
7921781	1	BN50726	86,93	PAF	70,73	BN50726	PAF	MESH:C061327	300795(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	Effect of a PAF antagonist , BN50726 .
2009789	0	BN52021	27,34	PAF	11,14	BN52021	PAF	MESH:C045856	9768	Chemical	Gene	methacholine|dep|START_ENTITY antagonist|dep|methacholine antagonist|compound|END_ENTITY	Effects of PAF antagonist , BN52021 , on the PAF - , methacholine - , and allergen-induced bronchoconstriction in asthmatic children .
2009789	0	BN52021	27,34	PAF	43,46	BN52021	PAF	MESH:C045856	9768	Chemical	Gene	methacholine|dep|START_ENTITY methacholine|nmod|END_ENTITY	Effects of PAF antagonist , BN52021 , on the PAF - , methacholine - , and allergen-induced bronchoconstriction in asthmatic children .
3339274	2	BN52021	325,332	PAF	387,390	BN52021	PAF	MESH:C045856	300795(Tax:10116)	Chemical	Gene	shown|nsubjpass|START_ENTITY shown|xcomp|inhibit inhibit|dobj|action action|nmod|END_ENTITY	Selective PAF antagonists BN52021 and L652-731 have been shown to inhibit the action of PAF in vitro and in vivo .
7703435	0	BN52021	16,23	PAF	0,3	BN52021	PAF	MESH:C045856	300795(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	PAF antagonist , BN52021 , inhibits -LSB- 3H -RSB- D-aspartate release after ischaemia in vitro .
3403863	0	BN52063	28,35	PAF	12,15	BN52063	PAF	MESH:C050422	9768	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	Effect of a PAF antagonist , BN52063 , on antigen-induced , acute , and late-onset cutaneous responses in atopic subjects .
8259265	0	BN_50730	110,118	platelet-activating_factor	71,97	BN 50730	platelet-activating factor	MESH:C066686	300795(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Prevention of chloroquine-induced electroretinographic_damage by a new platelet-activating_factor antagonist , BN_50730 .
2536413	0	BN_52021	170,178	platelet-activating_factor	14,40	BN 52021	platelet-activating factor	MESH:C045856	9768	Chemical	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of platelet-activating_factor -LRB- PAF -RRB- - induced chemotaxis and PAF binding to human eosinophils and neutrophils by the specific ginkgolide-derived PAF antagonist , BN_52021 .
2748916	0	BN_52021	100,108	platelet-activating_factor	55,81	BN 52021	platelet-activating factor	MESH:C045856	300795(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY rat|dep|antagonist rat|nmod|END_ENTITY	Modulation of eosinophil recruitment in the rat by the platelet-activating_factor -LRB- PAF -RRB- antagonist , BN_52021 , the somatostatin analog , BIM_23014 , and by cyclosporin_A .
2759659	0	BN_52021	57,65	platelet-activating_factor	18,44	BN 52021	platelet-activating factor	MESH:C045856	9768	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	The effect of the platelet-activating_factor antagonist , BN_52021 , on human natural killer cell-mediated cytotoxicity .
2825685	0	BN_52021	14,22	platelet-activating_factor	61,87	BN 52021	platelet-activating factor	MESH:C045856	9768	Chemical	Gene	ginkgolide_B|compound|START_ENTITY Inhibition|nmod|ginkgolide_B Inhibition|dep|END_ENTITY	Inhibition by BN_52021 -LRB- ginkgolide_B -RRB- of the binding of -LSB- 3H -RSB- - platelet-activating_factor to human neutrophil granulocytes .
2969600	0	BN_52021	47,55	platelet-activating_factor	83,109	BN 52021	platelet-activating factor	MESH:C045856	300795(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|nmod|END_ENTITY	Immune complex induced pancreatitis : effect of BN_52021 , a selective antagonist of platelet-activating_factor .
3046952	0	BN_52021	64,72	platelet-activating_factor	24,50	BN 52021	platelet-activating factor	MESH:C045856	300795(Tax:10116)	Chemical	Gene	Effects|appos|START_ENTITY Effects|nmod|antagonists antagonists|amod|END_ENTITY	Effects of the specific platelet-activating_factor antagonists , BN_52021 and BN_52063 , on various experimental gastrointestinal ulcerations .
3377969	0	BN_52021	10,18	platelet_activating_factor	22,48	BN 52021	platelet activating factor	MESH:C045856	109585(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|antagonist antagonist|compound|END_ENTITY	Effect of BN_52021 , a platelet_activating_factor antagonist , on experimental murine contact_dermatitis .
9705608	0	BN_52021	0,8	platelet_activating_factor-receptor	12,47	BN 52021	platelet activating factor-receptor	MESH:C045856	100720710	Chemical	Gene	START_ENTITY|dep|antagonist antagonist|amod|END_ENTITY	BN_52021 -LRB- a platelet_activating_factor-receptor antagonist -RRB- decreases alveolar macrophage-mediated lung_injury in experimental extrinsic_allergic_alveolitis .
23688700	0	BODIPY	70,76	HER2	87,91	BODIPY	HER2	MESH:C095489	2064	Chemical	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	Design , synthesis and characterization of peptidomimetic conjugate of BODIPY targeting HER2 protein extracellular domain .
10344637	0	BOF-4272	20,28	xanthine_oxidase	32,48	BOF-4272	xanthine oxidase	MESH:C072977	22436(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Pharmacokinetics of BOF-4272 , a xanthine_oxidase inhibitor , after single intravenous or oral administration to male mice and rats .
10714947	0	BOF-4272	66,74	xanthine_oxidase	78,94	BOF-4272	xanthine oxidase	MESH:C072977	22436(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Evaluation of the pharmacological actions and pharmacokinetics of BOF-4272 , a xanthine_oxidase inhibitor , in mouse liver .
26934298	0	BPA	0,3	GnRH	23,27	BPA	GnRH	null	2796	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|activity activity|amod|END_ENTITY	BPA directly decreases GnRH neuronal activity via non-canonical pathway .
25612011	0	BPA	87,90	Scgb2a1	32,39	BPA	Scgb2a1	null	25010(Tax:10116)	Chemical	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of secretaglobin Scgb2a1 as a target for developmental reprogramming by BPA in the rat prostate .
1381465	0	BPDE	53,57	hprt	65,69	BPDE	hprt	MESH:D015123	3251	Chemical	Gene	START_ENTITY|nmod|gene gene|amod|END_ENTITY	Strand specificity for mutations induced by -LRB- + -RRB- - anti BPDE in the hprt gene in human T-lymphocytes .
21707078	0	BPO	66,69	CFTR	71,75	BPO	CFTR	CHEBI:53702	1080	Chemical	Gene	inhibitors|appos|START_ENTITY inhibitors|compound|END_ENTITY	Potent , metabolically stable benzopyrimido-pyrrolo-oxazine-dione -LRB- BPO -RRB- CFTR inhibitors for polycystic_kidney_disease .
9190840	0	BP_2-94	68,75	histamine_H3_receptor	79,100	BP 2-94	histamine H3 receptor	MESH:C106714	11255	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Bioavailability , antinociceptive and antiinflammatory properties of BP_2-94 , a histamine_H3_receptor agonist prodrug .
12847556	0	BP_897	0,6	dopamine_D3_receptor	20,40	BP 897	dopamine D3 receptor	MESH:C120565	29238(Tax:10116)	Chemical	Gene	ligand|advmod|START_ENTITY ligand|nsubj|END_ENTITY	BP_897 , a selective dopamine_D3_receptor ligand with therapeutic potential for the treatment of cocaine-addiction .
15598141	0	BP_897	78,84	dopamine_D3_receptor	40,60	BP 897	dopamine D3 receptor	MESH:C120565	29238(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Intra-BLA or intra-NAc infusions of the dopamine_D3_receptor partial agonist , BP_897 , block intra-NAc amphetamine conditioned activity .
17492273	0	BP_897	89,95	dopamine_D3_receptor	59,79	BP 897	dopamine D3 receptor	MESH:C120565	29238(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Maternal_deprivation and handling modify the effect of the dopamine_D3_receptor agonist , BP_897 on morphine-conditioned place preference in rats .
11588120	0	BQ-123	38,44	ETA	9,12	BQ-123	ETA	MESH:C072247	1909	Chemical	Gene	antagonism|nmod|START_ENTITY antagonism|compound|END_ENTITY	Systemic ETA receptor antagonism with BQ-123 blocks ET-1 induced forearm vasoconstriction and decreases peripheral vascular resistance in healthy men .
12049621	0	BQ-123	51,57	ETA	35,38	BQ-123	ETA	MESH:C072247	1909	Chemical	Gene	antagonist|dobj|START_ENTITY antagonist|nsubj|Action Action|appos|END_ENTITY	Action of the endothelin receptor -LRB- ETA -RRB- antagonist BQ-123 on forearm blood flow in young normotensive subjects .
1282942	0	BQ-123	80,86	ETA	105,108	BQ-123	ETA	MESH:C072247	1909	Chemical	Gene	selective|nsubj|START_ENTITY selective|nmod|receptor receptor|compound|END_ENTITY	In vitro biological profile of a highly potent novel endothelin -LRB- ET -RRB- antagonist BQ-123 selective for the ETA receptor .
1318228	0	BQ-123	24,30	ETA	8,11	BQ-123	ETA	MESH:C072247	24326(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	A novel ETA antagonist -LRB- BQ-123 -RRB- inhibits endothelin-1-induced phosphoinositide breakdown and DNA synthesis in rat vascular smooth muscle cells .
1417963	0	BQ-123	64,70	ETA	48,51	BQ-123	ETA	MESH:C072247	1909	Chemical	Gene	antagonist|dobj|START_ENTITY antagonist|nsubj|effects effects|appos|END_ENTITY	Suppressive effects of the endothelin receptor -LRB- ETA -RRB- antagonist BQ-123 on ET-1-induced reduction of lipoprotein_lipase activity in 3T3-L1 adipocytes .
7606751	0	BQ-123	39,45	ETA	10,13	BQ-123	ETA	MESH:C072247	24326(Tax:10116)	Chemical	Gene	antagonism|nmod|START_ENTITY antagonism|compound|END_ENTITY	Selective ETA receptor antagonism with BQ-123 is insufficient to inhibit angioplasty induced neointima formation in the rat .
7842471	0	BQ-123	39,45	ETA	23,26	BQ-123	ETA	MESH:C072247	1909	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	A selective endothelin ETA antagonist , BQ-123 , inhibits 125I-endothelin-1 -LRB- 125I-ET-1 -RRB- binding to human meningiomas and antagonizes ET-1-induced proliferation of meningioma cells .
7931624	0	BQ-123	74,80	ETA	49,52	BQ-123	ETA	MESH:C072247	1909	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	Prevention of delayed vasospasm by an endothelin ETA receptor antagonist , BQ-123 : change of ETA receptor mRNA expression in a canine subarachnoid_hemorrhage model .
7931624	0	BQ-123	74,80	ETA	92,95	BQ-123	ETA	MESH:C072247	1909	Chemical	Gene	antagonist|appos|START_ENTITY vasospasm|nmod|antagonist Prevention|nmod|vasospasm Prevention|dep|change change|nmod|expression expression|compound|END_ENTITY	Prevention of delayed vasospasm by an endothelin ETA receptor antagonist , BQ-123 : change of ETA receptor mRNA expression in a canine subarachnoid_hemorrhage model .
8587358	0	BQ-123	197,203	ETA	130,133	BQ-123	ETA	MESH:C072247	24326(Tax:10116)	Chemical	Gene	using|dobj|START_ENTITY antagonism|acl|using antagonism|compound|END_ENTITY	Endothelin receptor subtypes in the pathogenesis of angioplasty-induced neointima formation in the rat : a comparison of selective ETA receptor antagonism and dual ETA/ETB receptor antagonism using BQ-123 and SB_209670 .
8843795	0	BQ-123	22,28	ETA	33,36	BQ-123	ETA	MESH:C072247	24326(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Protective effects of BQ-123 , an ETA receptor antagonist , against leukotoxin-induced injury_in_rat_lungs .
8242251	17	BQ-123	2052,2058	ETB	2086,2089	BQ-123	ETA	MESH:C072247	24326(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|response response|compound|END_ENTITY	In the rat isolated perfused mesentery ET-1 or SX6c -LRB- 0.3-300pmol -RRB- were equipotent in producing dose-related vasodilatations that were unaffected by BQ-123 -LRB- 10-6 M -RRB- , indicative of an ETB receptor mediated response .
8677766	0	BQ-123	56,62	endothelin-1	11,23	BQ-123	endothelin-1	MESH:C072247	1906	Chemical	Gene	antagonist|dobj|START_ENTITY antagonist|nsubj|Effects Effects|nmod|END_ENTITY	Effects of endothelin-1 and the ETA receptor antagonist BQ-123 on resistance arteries from normal pregnant and preeclamptic women .
9814615	0	BQ-123	11,17	endothelin-1	65,77	BQ-123	endothelin-1	MESH:C072247	24323(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|responses responses|nmod|END_ENTITY	Effects of BQ-123 on systemic and renal hemodynamic responses to endothelin-1 in the rat split hydronephrotic kidney .
8575114	0	BQ-123	57,63	endothelin_A-receptor	23,44	BQ-123	endothelin A-receptor	MESH:C072247	24326(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Effects of a selective endothelin_A-receptor antagonist , BQ-123 , in salt-loaded stroke-prone spontaneously hypertensive rats .
8587427	0	BQ-485	11,17	ETA	31,34	BQ-485	ETA	MESH:C083116	24326(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Effects of BQ-485 , a selective ETA antagonist , on endothelin-mediated vasomotion in rat coronary vascular beds .
9051826	0	BQ-485	38,44	endothelin-1	13,25	BQ-485	endothelin-1	MESH:C083116	403424(Tax:9615)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Effect of an endothelin-1 antagonist , BQ-485 , on cerebral oxygen metabolism after complete global cerebral_ischemia in dogs .
20638381	0	BQ123	33,38	Endothelin-A_receptor	0,21	BQ123	Endothelin-A receptor	MESH:C072247	24326(Tax:10116)	Chemical	Gene	potentiates|compound|START_ENTITY potentiates|amod|END_ENTITY	Endothelin-A_receptor antagonist BQ123 potentiates acetaminophen induced hypothermia and reduces infarction following focal cerebral_ischemia in rats .
7596133	0	BQ123	57,62	endothelin-1	11,23	BQ123	endothelin-1	MESH:C072247	24323(Tax:10116)	Chemical	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of endothelin-1 and the ETA-receptor antagonist , BQ123 , on ischemic_arrhythmias in anesthetized rats .
8968269	0	BQ123	132,137	endothelin-A_receptor	98,119	BQ123	endothelin-A receptor	MESH:C072247	24326(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Endothelin-1-induced contraction of pulmonary arteries from endotoxemic rats is attenuated by the endothelin-A_receptor antagonist , BQ123 .
8847864	0	BQ610	58,63	endothelin-1	34,46	BQ610	endothelin-1	MESH:C087220	24323(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|antagonist antagonist|amod|END_ENTITY	Protective effect of the specific endothelin-1 antagonist BQ610 on mechanical function and energy metabolism during ischemia/reperfusion injury in isolated perfused rat hearts .
8946341	0	BRL37344	33,41	glucose_transporter	147,166	BRL37344	glucose transporter	MESH:C057368	25139(Tax:10116)	Chemical	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|END_ENTITY	Comparison of isoproterenol with BRL37344 in activation of beta 3-adrenoceptors to inhibit the uptake of -LSB- 14C -RSB- deoxy-D-glucose and translocation of glucose_transporter -LRB- GLUT4 -RRB- to membrane fraction in rat adipocytes .
7773551	0	BRL_35135	50,59	beta_3-adrenoceptor	21,40	BRL 35135	beta 3-adrenoceptor	MESH:C063157	25645(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Acute effects of the beta_3-adrenoceptor agonist , BRL_35135 , on tissue glucose utilisation .
7889277	0	BRL_35135	85,94	beta_3-adrenoceptor	57,76	BRL 35135	beta 3-adrenoceptor	MESH:C063157	25645(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Potentiation Potentiation|nmod|effect effect|nmod|agonist agonist|amod|END_ENTITY	Potentiation of the anti-obesity effect of the selective beta_3-adrenoceptor agonist BRL_35135 in obese Zucker rats by exercise .
8920957	0	BRL_35135A	118,128	leptin	55,61	BRL 35135A	leptin	MESH:C063157	16846(Tax:10090)	Chemical	Gene	circulating|nmod|START_ENTITY circulating|dobj|levels levels|compound|END_ENTITY	Rapid inhibition of ob gene expression and circulating leptin levels in lean mice by the beta_3-adrenoceptor agonists BRL_35135A and ZD2079 .
7995389	0	BRL_37344	30,39	Beta_3-adrenoceptor	0,19	BRL 37344	Beta 3-adrenoceptor	MESH:C057368	155	Chemical	Gene	agonists|appos|START_ENTITY agonists|amod|END_ENTITY	Beta_3-adrenoceptor agonists , BRL_37344 and SR 58611A , do not induce relaxation of human , sheep and guinea-pig airway smooth muscle in vitro .
2155065	0	BRL_43694	22,31	5-HT3	4,9	BRL 43694	5-HT3	MESH:D017829	15561(Tax:10090)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	The 5-HT3 antagonist , BRL_43694 , does not compromise the efficacy of cisplatin in tumour-bearing mice .
2157603	0	BRL_43694	8,17	5-HT3_receptor	31,45	BRL 43694	5-HT3 receptor	MESH:D017829	79246(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Chronic BRL_43694 , a selective 5-HT3_receptor antagonist , fails to alter the number of spontaneously active midbrain dopamine neurons .
7993957	0	BRL_46470	22,31	5-HT3	4,9	BRL 46470	5-HT3	MESH:C075685	3359	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	The 5-HT3 antagonist , BRL_46470 does not attenuate m-chlorophenylpiperazine -LRB- mCPP -RRB- - induced changes in human volunteers .
10869556	0	BRL_49653	114,123	Bone_morphogenetic_protein-2	0,28	BRL 49653	Bone morphogenetic protein-2	MESH:C089730	29373(Tax:10116)	Chemical	Gene	stimulates|nmod|START_ENTITY stimulates|nsubj|END_ENTITY	Bone_morphogenetic_protein-2 stimulates adipogenic differentiation of mesenchymal precursor cells in synergy with BRL_49653 -LRB- rosiglitazone -RRB- .
27042010	0	BS-181	31,37	CDK7	10,14	BS-181	CDK7	MESH:C000592924	1022	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Selective CDK7 inhibition with BS-181 suppresses cell proliferation and induces cell cycle arrest and apoptosis in gastric_cancer .
12270450	0	BSF_208075	64,74	endothelin-a_receptor	30,51	BSF 208075	endothelin-a receptor	MESH:C467894	397457(Tax:9823)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Administration of a selective endothelin-a_receptor antagonist -LRB- BSF_208075 -RRB- improves hepatic warm ischemia/reperfusion injury in pigs .
11750590	0	BSF_208075	67,77	endothelin_a_receptor	33,54	BSF 208075	endothelin a receptor	MESH:C467894	397457(Tax:9823)	Chemical	Gene	effect|appos|START_ENTITY effect|nmod|antagonist antagonist|compound|END_ENTITY	Protective effect of a selective endothelin_a_receptor antagonist -LRB- BSF_208075 -RRB- on graft pancreatitis in pig pancreas transplantation .
16275532	0	BSF_461314	81,91	endothelin-A_receptor	48,69	BSF 461314	endothelin-A receptor	null	397457(Tax:9823)	Chemical	Gene	antagonist|dobj|START_ENTITY antagonist|nsubj|effects effects|nmod|END_ENTITY	Cardioprotective effects of the novel selective endothelin-A_receptor antagonist BSF_461314 in ischemia-reperfusion injury .
21905824	0	BTM-0512	33,41	SIRT1	108,113	BTM-0512	SIRT1	MESH:C497286	23411	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|role role|nmod|END_ENTITY	Effect of resveratrol derivative BTM-0512 on high glucose-induced dysfunction of endothelial cells : role of SIRT1 .
10985927	0	BW2258U89	18,27	GRP_receptor	31,43	BW2258U89	GRP receptor	MESH:C077908	2925	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	The metabolism of BW2258U89 , a GRP_receptor antagonist .
3346546	0	BW5147	36,42	T_cell_receptor_beta-chain	0,26	BW5147	T cell receptor beta-chain	null	21577(Tax:10090)	Chemical	Gene	genes|nmod|START_ENTITY genes|amod|END_ENTITY	T_cell_receptor_beta-chain genes in BW5147 and other AKR_tumors .
2413896	0	BW755C	0,6	5-lipoxygenase	20,34	BW755C	5-lipoxygenase	MESH:D015772	11689(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	BW755C inhibits the 5-lipoxygenase in E-mast cells without affecting degranulation .
2128585	0	BW755C	51,57	lipoxygenase	28,40	BW755C	lipoxygenase	MESH:D015772	100009114(Tax:9986)	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|Effects Effects|nmod|END_ENTITY	Effects of the arachidonate lipoxygenase inhibitor BW755C on traumatic and peritumoural brain_oedema .
16178722	0	BX471	0,5	CCR1	9,13	BX471	CCR1	MESH:C411885	1230	Chemical	Gene	START_ENTITY|dep|antagonist antagonist|compound|END_ENTITY	BX471 : a CCR1 antagonist with anti-inflammatory activity in man .
17312463	0	BX471	15,20	CCR1	35,39	BX471	CCR1	MESH:C411885	12768(Tax:10090)	Chemical	Gene	Treatment|nmod|START_ENTITY Treatment|appos|antagonist antagonist|compound|END_ENTITY	Treatment with BX471 , a nonpeptide CCR1 antagonist , protects mice against acute_pancreatitis-associated lung_injury by modulating neutrophil recruitment .
19307177	0	BX795	37,42	TBK1	94,98	BX795	TBK1	MESH:C579675	29110	Chemical	Gene	study|nsubj|START_ENTITY study|dobj|roles roles|nmod|END_ENTITY	Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IkappaB_kinase_epsilon : a distinct upstream kinase mediates Ser-172 phosphorylation and activation .
26607461	0	BX795	0,5	TBK1	9,13	BX795	TBK1	MESH:C579675	29110	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	BX795 , a TBK1 inhibitor , exhibits antitumor activity in human oral_squamous_cell_carcinoma through apoptosis induction and mitotic phase arrest .
16003237	0	BXL-628	71,78	vitamin_D_receptor	99,117	BXL-628	vitamin D receptor	MESH:C487049	22337(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Inhibition of acute and chronic allograft rejection in mouse models by BXL-628 , a nonhypercalcemic vitamin_D_receptor agonist .
17163492	0	BXL-628	0,7	vitamin_D_receptor	11,29	BXL-628	vitamin D receptor	MESH:C487049	24873(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	BXL-628 , a vitamin_D_receptor agonist effective in benign_prostatic_hyperplasia treatment , prevents RhoA activation and inhibits RhoA/Rho kinase signaling in rat and human bladder .
16368897	0	BYK191023	54,63	inducible_nitric-oxide_synthase	173,204	BYK191023	inducible nitric-oxide synthase	MESH:C507627	24599(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|-RSB- -RSB-|appos|inhibitor inhibitor|nmod|END_ENTITY	In vivo characterization of the novel imidazopyridine BYK191023 -LSB- 2 - -LSB- 2 - -LRB- 4-methoxy-pyridin-2-yl -RRB- - ethyl -RSB- -3 H-imidazo -LSB- 4,5-b -RSB- pyridine -RSB- , a potent and highly selective inhibitor of inducible_nitric-oxide_synthase .
18178668	0	BYK191023	0,9	inducible_nitric-oxide_synthase	133,164	BYK191023	inducible nitric-oxide synthase	MESH:C507627	4843	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	BYK191023 -LRB- 2 - -LSB- 2 - -LRB- 4-methoxy-pyridin-2-yl -RRB- - ethyl -RSB- -3 h-imidazo -LSB- 4,5-b -RSB- pyridine -RRB- is an NADPH - and time-dependent irreversible inhibitor of inducible_nitric-oxide_synthase .
24961790	0	BYL719	0,6	PI3K	25,29	BYL719	PI3K	null	5293	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	BYL719 , a new a-specific PI3K inhibitor : single administration and in combination with conventional chemotherapy for the treatment of osteosarcoma .
19345205	0	BZYX	0,4	acetylcholinesterase	14,34	BZYX	acetylcholinesterase	null	83817(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	BZYX , a novel acetylcholinesterase inhibitor , significantly improved chemicals-induced learning_and_memory_impairments on rodents and protected PC12 cells from apoptosis induced by hydrogen_peroxide .
6215537	0	B_cyclopropanoandrostanes	91,116	Androgen_receptor	0,17	B cyclopropanoandrostanes	Androgen receptor	null	367	Chemical	Gene	activity|nmod|START_ENTITY END_ENTITY|dobj|activity	Androgen_receptor binding and antiandrogenic activity of some 4,5-secoandrostanes and ring B_cyclopropanoandrostanes .
3643213	0	Ba	51,53	C3b	63,66	Ba	C3b	null	718	Chemical	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Alternative complement pathway activation fragment Ba binds to C3b .
20477872	0	Bacitracin	0,10	disulfide_isomerase	50,69	Bacitracin	disulfide isomerase	MESH:D001414	79770	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Bacitracin is not a specific inhibitor of protein disulfide_isomerase .
27061166	0	Baclofen	56,64	multiple_sclerosis	68,86	Baclofen	multiple sclerosis	MESH:D001418	4397	Chemical	Gene	START_ENTITY|nmod|patients patients|amod|END_ENTITY	Effects of severe spasticity treatment with intrathecal Baclofen in multiple_sclerosis patients : Long term follow-up .
3005001	0	Baclofen	0,8	prolactin	53,62	Baclofen	prolactin	MESH:D001418	24683(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|compound|END_ENTITY	Baclofen , a GABA derivative , inhibits stress-induced prolactin release in the rat .
19100480	0	Bacteriocins	0,12	tumor_necrosis_factor-alpha	49,76	Bacteriocins	tumor necrosis factor-alpha	CHEBI:48081	24835(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Bacteriocins from lactic_acid bacteria increases tumor_necrosis_factor-alpha expression in a rat kidney model of chronic rejection .
14641442	0	Bacteroides	62,73	interleukin-8	13,26	Bacteroides	interleukin-8	null	3576	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Induction of interleukin-8 gene expression by black-pigmented Bacteroides in human pulp fibroblasts and osteoblasts .
20428797	0	Baicalein	0,9	ERK	59,62	Baicalein	ERK	MESH:C006680	26413(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|activation activation|nmod|END_ENTITY	Baicalein inhibits melanogenesis through activation of the ERK signaling pathway .
22204275	0	Baicalein	0,9	Ezrin	86,91	Baicalein	Ezrin	MESH:C006680	7430	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Baicalein mediates inhibition of migration and invasiveness of skin_carcinoma through Ezrin in A431 cells .
25004875	0	Baicalein	0,9	HMGB1	19,24	Baicalein	HMGB1	MESH:C006680	3146	Chemical	Gene	release|compound|START_ENTITY release|compound|END_ENTITY	Baicalein inhibits HMGB1 release and MMP-2 / -9 expression in lipopolysaccharide-induced cardiac_hypertrophy .
18039391	0	Baicalein	0,9	IL-1beta	19,27	Baicalein	IL-1beta	MESH:C006680	3553	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Baicalein inhibits IL-1beta - and TNF-alpha-induced inflammatory cytokine production from human mast cells via regulation of the NF-kappaB pathway .
26348633	0	Baicalein	0,9	MCP-1	52,57	Baicalein	MCP-1	MESH:C006680	24770(Tax:10116)	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Baicalein Inhibits Amadori-Glycated Albumin-Induced MCP-1 Expression in Retinal Ganglion Cells via a MicroRNA-124-Dependent Mechanism .
26348633	0	Baicalein	0,9	MCP-1	52,57	Baicalein	MCP-1	MESH:C006680	24770(Tax:10116)	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Baicalein Inhibits Amadori-Glycated Albumin-Induced MCP-1 Expression in Retinal Ganglion Cells via a MicroRNA-124-Dependent Mechanism .
12568909	0	Baicalein	0,9	MEK-1	53,58	Baicalein	MEK-1	MESH:C006680	170851(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Baicalein inhibits Raf-1-mediated phosphorylation of MEK-1 in C6 rat glioma cells .
25811965	0	Baicalein	0,9	MMP-2	19,24	Baicalein	MMP-2	MESH:C006680	4313	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Baicalein inhibits MMP-2 expression in human ovarian_cancer cells by suppressing the p38 MAPK-dependent NF-kB signaling pathway .
22820424	0	Baicalein	0,9	cyclin_D1	81,90	Baicalein	cyclin D1	MESH:C006680	595	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|enhancing enhancing|dobj|degradation degradation|nmod|END_ENTITY	Baicalein induces G1_arrest in oral_cancer cells by enhancing the degradation of cyclin_D1 and activating AhR to decrease Rb phosphorylation .
23523661	0	Baicalein	0,9	miR-21	88,94	Baicalein	miR-21	MESH:C006680	100314000(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|nmod|inhibition inhibition|nmod|END_ENTITY	Baicalein attenuates bleomycin-induced pulmonary_fibrosis in rats through inhibition of miR-21 .
18974136	0	Baicalein	0,9	tumor_necrosis_factor-related_apoptosis-inducing_ligand	20,75	Baicalein	tumor necrosis factor-related apoptosis-inducing ligand	MESH:C006680	8743	Chemical	Gene	overcomes|nsubj|START_ENTITY overcomes|dobj|resistance resistance|amod|END_ENTITY	Baicalein overcomes tumor_necrosis_factor-related_apoptosis-inducing_ligand resistance via two different cell-specific pathways in cancer cells but not in normal cells .
23710212	0	Baicalin	22,30	CYP3A	65,70	Baicalin	CYP3A	MESH:C038044	170509(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|Expression Expression|nmod|END_ENTITY	Inhibitory Effects of Baicalin on the Expression and Activity of CYP3A Induce the Pharmacokinetic Changes of Midazolam in Rats .
26783516	0	Baicalin	8,16	IFN-Gamma	66,75	Baicalin	IFN-Gamma	MESH:C038044	3458	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of Baicalin in Anti-Influenza Virus A as a Potent Inducer of IFN-Gamma .
26480816	0	Baicalin	0,8	SGK1	19,23	Baicalin	SGK1	MESH:C038044	20393(Tax:10090)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|nummod|END_ENTITY	Baicalin decreases SGK1 expression in the hippocampus and reverses depressive-like behaviors induced by corticosterone .
20859668	0	Baicalin	0,8	TLR2/4	18,24	Baicalin	TLR2/4	MESH:C038044	310553;29260	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Baicalin inhibits TLR2/4 signaling pathway in rat brain following permanent cerebral_ischemia .
21612566	0	Baicalin	0,8	TLR2/4	34,40	Baicalin	TLR2/4	MESH:C038044	24088(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|nmod|END_ENTITY	Baicalin suppresses expression of TLR2/4 and NF-kB in chlamydia_trachomatis-infected mice .
23116637	0	Baicalin	0,8	TLR4	129,133	Baicalin	TLR4	MESH:C038044	29260(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|nmod|deprived deprived|acl|challenged challenged|advcl|inhibiting inhibiting|dobj|END_ENTITY	Baicalin attenuates proinflammatory cytokine production in oxygen-glucose deprived challenged rat microglial cells by inhibiting TLR4 signaling pathway .
25550915	0	Baicalin	0,8	TLR4	42,46	Baicalin	TLR4	MESH:C038044	21898(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Baicalin down regulates the expression of TLR4 and NFkB-p65 in colon tissue in mice with colitis induced by dextran sulfate sodium .
19387806	0	Baicalin	11,19	TNF-alpha	48,57	Baicalin	TNF-alpha	MESH:C038044	24835(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|level level|amod|END_ENTITY	Effects of Baicalin and Octreotide on the serum TNF-alpha level and apoptosis in multiple organs of rats with severe acute pancreatitis .
20851810	0	Baicalin	0,8	VEGF	19,23	Baicalin	VEGF	MESH:C038044	7422	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Baicalin increases VEGF expression and angiogenesis by activating the ERR -LCB- alpha -RCB- / PGC-1 -LCB- alpha -RCB- pathway .
24430548	0	Baicalin	0,8	high-mobility_group_box_1	18,43	Baicalin	high-mobility group box 1	MESH:C038044	15289(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|amod|END_ENTITY	Baicalin inhibits high-mobility_group_box_1 release and improves survival in experimental sepsis .
26617721	0	Baicalin	0,8	iNOS	79,83	Baicalin	iNOS	MESH:C038044	24599(Tax:10116)	Chemical	Gene	ameliorates|nsubj|START_ENTITY ameliorates|nmod|stress stress|compound|END_ENTITY	Baicalin ameliorates isoproterenol-induced acute_myocardial_infarction through iNOS , inflammation and oxidative stress in rat .
26885181	0	Baicalin	0,8	iNOS	79,83	Baicalin	iNOS	MESH:C038044	24599(Tax:10116)	Chemical	Gene	ameliorates|nsubj|START_ENTITY ameliorates|nmod|END_ENTITY	Baicalin ameliorates isoproterenol-induced acute_myocardial_infarction through iNOS , inflammation , oxidative stress and P38MAPK pathway in rat .
21887805	0	Baicalin	0,8	macrophage_migration_inhibitory_factor	42,80	Baicalin	macrophage migration inhibitory factor	MESH:C038044	103694877	Chemical	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|nmod|END_ENTITY	Baicalin down-regulates the expression of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- effectively for rats with ulcerative_colitis .
18650094	0	Baicalin	0,8	prolyl_oligopeptidase	48,69	Baicalin	prolyl oligopeptidase	MESH:C038044	5550	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|amod|END_ENTITY	Baicalin , a prodrug able to reach the CNS , is a prolyl_oligopeptidase inhibitor .
23504578	0	Baicalin	0,8	protease-activated_receptor-1	80,109	Baicalin	protease-activated receptor-1	MESH:C038044	25439(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|nmod|inhibition inhibition|nmod|END_ENTITY	Baicalin attenuates focal cerebral ischemic_reperfusion_injury by inhibition of protease-activated_receptor-1 and apoptosis .
26823714	0	Baicalin	0,8	thrombin	26,34	Baicalin	thrombin	MESH:C038044	2147	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|END_ENTITY	Baicalin protects against thrombin induced cell injury in SH-SY5Y cells .
26902638	0	Bakuchiol	0,9	MyoD	19,23	Bakuchiol	MyoD	MESH:C012765	4654	Chemical	Gene	augments|amod|START_ENTITY END_ENTITY|nsubj|augments	Bakuchiol augments MyoD activation leading to enhanced myoblast differentiation .
27033605	0	Bakuchiol	0,9	TRAIL	37,42	Bakuchiol	TRAIL	MESH:C012765	8743	Chemical	Gene	sensitizes|nsubj|START_ENTITY sensitizes|dobj|cells cells|acl|END_ENTITY	Bakuchiol sensitizes cancer cells to TRAIL through ROS - and JNK-mediated upregulation of death receptors and downregulation of survival proteins .
8391183	2	BamHI	371,376	EBV	391,394	BamHI	p13	null	440926	Chemical	Gene	region|compound|START_ENTITY region|nmod|END_ENTITY	FISH analysis after hybridization with a BamHI `` V '' region of EBV showed that NAB-2 cells have EBV genome integrated at a single site on the short arm of chromosome 2 -LRB- p13 -RRB- .
25504505	0	Bambuterol	80,90	Butyrylcholinesterase	36,57	Bambuterol	Butyrylcholinesterase	MESH:C047766	590	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Stereoselective Inhibition of Human Butyrylcholinesterase by the Enantiomers of Bambuterol and their Intermediates .
10630104	0	Barbarin	0,8	tyrosinase	18,28	Barbarin	tyrosinase	MESH:C403584	22173(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|compound|END_ENTITY	Barbarin as a new tyrosinase inhibitor from Barbarea orthocerus .
2431244	0	Barbiturate	0,11	GABA_receptor	45,58	Barbiturate	GABA receptor	MESH:C032232	11337	Chemical	Gene	modulation|amod|START_ENTITY modulation|nmod|END_ENTITY	Barbiturate and benzodiazepine modulation of GABA_receptor binding and function .
8952470	0	Barbiturate	0,11	GLUT-1	26,32	Barbiturate	GLUT-1	MESH:C032232	6513	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Barbiturate inhibition of GLUT-1 mediated hexose transport in human erythrocytes exhibits substrate dependence for equilibrium exchange but not unidirectional sugar flux .
9748518	0	Barbiturates	0,12	vascular_endothelial_growth_factor	40,74	Barbiturates	vascular endothelial growth factor	MESH:D001463	7422	Chemical	Gene	decrease|nsubj|START_ENTITY decrease|dobj|expression expression|nmod|END_ENTITY	Barbiturates decrease the expression of vascular_endothelial_growth_factor in hypoxic cultures of porcine brain derived microvascular endothelial cells .
21289052	0	Bardoxolone_methyl	0,18	Nrf2	96,100	Bardoxolone methyl	Nrf2	MESH:C445068	18024(Tax:10090)	Chemical	Gene	ameliorates|nsubj|START_ENTITY ameliorates|dobj|AKI AKI|nmod|END_ENTITY	Bardoxolone_methyl -LRB- BARD -RRB- ameliorates ischemic AKI and increases expression of protective genes Nrf2 , PPARy , and HO-1 .
24530882	0	Bardoxolone_methyl	0,18	Nrf2	97,101	Bardoxolone methyl	Nrf2	MESH:C445068	18024(Tax:10090)	Chemical	Gene	ameliorates|amod|START_ENTITY aristolochic_acid|nsubj|ameliorates aristolochic_acid|dobj|AA AA|acl|induced induced|nmod|pathway pathway|amod|END_ENTITY	Bardoxolone_methyl -LRB- BARD -RRB- ameliorates aristolochic_acid -LRB- AA -RRB- - induced acute_kidney_injury through Nrf2 pathway .
22859857	0	Bardoxolone_methyl	0,18	nrf2	51,55	Bardoxolone methyl	nrf2	MESH:C445068	4780	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|END_ENTITY	Bardoxolone_methyl decreases megalin and activates nrf2 in the kidney .
18433733	0	Bavachalcone	0,12	RANKL	92,97	Bavachalcone	RANKL	MESH:C508227	8600	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Bavachalcone inhibits osteoclast differentiation through suppression of NFATc1 induction by RANKL .
26199639	0	Bavachalcone	0,12	RORa	22,26	Bavachalcone	RORa	MESH:C508227	6095	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Bavachalcone Enhances RORa Expression , Controls Bmal1 Circadian Transcription , and Depresses Cellular Senescence in Human Endothelial Cells .
26199639	0	Bavachalcone	0,12	RORa	22,26	Bavachalcone	RORa	MESH:C508227	6095	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Bavachalcone Enhances RORa Expression , Controls Bmal1 Circadian Transcription , and Depresses Cellular Senescence in Human Endothelial Cells .
24116293	0	Bavachin	35,43	Estrogen_Receptor	14,31	Bavachin	Estrogen Receptor	MESH:C459212	2099	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of Estrogen_Receptor by Bavachin from Psoralea corylifolia .
26557867	0	Bavachinin	40,50	Monoamine_Oxidases_A_and_B	73,99	Bavachinin	Monoamine Oxidases A and B	MESH:C468752	4128;4129	Chemical	Gene	Evaluation|nmod|START_ENTITY Evaluation|nmod|END_ENTITY	Evaluation of the Inhibitory Effects of Bavachinin and Bavachin on Human Monoamine_Oxidases_A_and_B .
7541100	0	Bay_K_8644	47,57	endothelin-1	10,22	Bay K 8644	endothelin-1	MESH:D001498	1906	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of endothelin-1 on arterial response to Bay_K_8644 .
2416580	0	Bay_K_8644	29,39	renin	50,55	Bay K 8644	renin	MESH:D001498	24715(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY inhibits|nsubj|agonist inhibits|dobj|release release|compound|END_ENTITY	The calcium channel agonist , Bay_K_8644 , inhibits renin release from rat kidney cortical slices .
17676432	0	BcMF5	0,5	pollen_coat_protein	9,28	BcMF5	pollen coat protein	null	5547	Chemical	Gene	START_ENTITY|appos|gene gene|compound|END_ENTITY	BcMF5 , a pollen_coat_protein gene -LRB- PCP -RRB- , from Brassica rapa .
16605946	0	Be-Au	51,56	Spin	0,4	Be-Au	Spin	null	10927	Chemical	Gene	effect|nmod|START_ENTITY effect|compound|END_ENTITY	Spin proximity effect in ultrathin superconducting Be-Au bilayers .
15533592	0	Beauvericin	0,11	caspase_3	112,121	Beauvericin	caspase 3	MESH:C004456	836	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|amod|END_ENTITY	Beauvericin induces cytotoxic effects in human acute_lymphoblastic_leukemia cells through cytochrome_c release , caspase_3 activation : the causative role of calcium .
15533592	0	Beauvericin	0,11	cytochrome_c	90,102	Beauvericin	cytochrome c	MESH:C004456	54205	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|amod|END_ENTITY	Beauvericin induces cytotoxic effects in human acute_lymphoblastic_leukemia cells through cytochrome_c release , caspase_3 activation : the causative role of calcium .
8613928	0	Befloxatone	0,11	monoamine_oxidase-A	44,63	Befloxatone	monoamine oxidase-A	MESH:C090014	29253(Tax:10116)	Chemical	Gene	inhibitor|advmod|START_ENTITY inhibitor|nsubj|END_ENTITY	Befloxatone , a new reversible and selective monoamine_oxidase-A inhibitor .
8613929	0	Befloxatone	0,11	monoamine_oxidase-A	44,63	Befloxatone	monoamine oxidase-A	MESH:C090014	29253(Tax:10116)	Chemical	Gene	inhibitor|advmod|START_ENTITY inhibitor|nsubj|END_ENTITY	Befloxatone , a new reversible and selective monoamine_oxidase-A inhibitor .
25446774	0	Benazepril	155,165	ACE	126,129	Benazepril	ACE	MESH:C044946	610668(Tax:9615)	Chemical	Gene	Therapy|nmod|START_ENTITY Therapy|nsubj|Modeling Modeling|nmod|Biomarkers Biomarkers|nmod|Inhibition Inhibition|appos|END_ENTITY	Pharmacokinetic/Pharmacodynamic Modeling of Renin-Angiotensin Aldosterone Biomarkers Following Angiotensin-Converting_Enzyme -LRB- ACE -RRB- Inhibition Therapy with Benazepril in Dogs .
8512378	0	Benazepril	0,10	ACE	18,21	Benazepril	ACE	MESH:C044946	1636	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Benazepril : a new ACE inhibitor .
22152322	0	Benazepril	11,21	ACE2	43,47	Benazepril	ACE2	MESH:C044946	302668(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of Benazepril on the expression of ACE2 in rats with hepatic_fibrosis . -RSB-
25446774	0	Benazepril	155,165	Angiotensin-Converting_Enzyme	95,124	Benazepril	Angiotensin-Converting Enzyme	MESH:C044946	610668(Tax:9615)	Chemical	Gene	Therapy|nmod|START_ENTITY Therapy|nsubj|Modeling Modeling|nmod|Biomarkers Biomarkers|nmod|Inhibition Inhibition|compound|END_ENTITY	Pharmacokinetic/Pharmacodynamic Modeling of Renin-Angiotensin Aldosterone Biomarkers Following Angiotensin-Converting_Enzyme -LRB- ACE -RRB- Inhibition Therapy with Benazepril in Dogs .
9431834	0	Benazepril	0,10	angiotensin_converting_enzyme	15,44	Benazepril	angiotensin converting enzyme	MESH:C044946	1636	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Benazepril , an angiotensin_converting_enzyme inhibitor : drug interaction with salbutamol and bronchial response to histamine in normal subjects .
25142208	0	Benazepril	0,10	integrin-linked_kinase	19,41	Benazepril	integrin-linked kinase	MESH:C044946	170922(Tax:10116)	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|expression expression|amod|END_ENTITY	Benazepril affects integrin-linked_kinase and smooth muscle a-actin expression in diabetic rat glomerulus and cultured mesangial cells .
8065551	0	Benextramine	0,12	NPY	17,20	Benextramine	NPY	MESH:C029998	24604(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Benextramine , an NPY antagonist , improves sexual behavior in male rats .
11409647	0	Benidipine	0,10	ET-1	34,38	Benidipine	ET-1	MESH:C061004	24323(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Benidipine inhibits expression of ET-1 and TGF-beta1 in Dahl salt-sensitive hypertensive rats .
11459076	0	Benserazide	0,11	AADC	30,34	Benserazide	AADC	MESH:D001545	24311(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|levels levels|compound|END_ENTITY	Benserazide decreases central AADC activity , extracellular dopamine levels and levodopa decarboxylation in striatum of the rat .
11034785	0	Benzalkonium_Chloride	19,40	Butyrylcholinesterase	92,113	Benzalkonium Chloride	Butyrylcholinesterase	MESH:D001548	590	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Distinct Effect of Benzalkonium_Chloride on the Esterase and Aryl Acylamidase Activities of Butyrylcholinesterase .
10467347	0	Benzamide_riboside	0,18	Cdc25A	52,58	Benzamide riboside	Cdc25A	MESH:C076145	993	Chemical	Gene	induces|nsubj|START_ENTITY induces|xcomp|independent independent|nmod|expression expression|amod|END_ENTITY	Benzamide_riboside induces apoptosis independent of Cdc25A expression in human ovarian_carcinoma N. 1 cells .
2751686	0	Benzanthrone	0,12	cytochrome_P-450	53,69	Benzanthrone	cytochrome P-450	MESH:C012768	25251(Tax:10116)	Chemical	Gene	START_ENTITY|dep|substrate substrate|nmod|END_ENTITY	Benzanthrone : a new substrate for hepatic microsomal cytochrome_P-450 .
21520952	0	Benzbromarone	0,13	CFTR	32,36	Benzbromarone	CFTR	MESH:D001553	1080	Chemical	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	Benzbromarone stabilizes / \ F508 CFTR at the cell surface .
26693855	0	Benzbromarone	26,39	CYP3A4	16,22	Benzbromarone	CYP3A4	MESH:D001553	1576	Chemical	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of CYP3A4 by Benzbromarone in Human Liver Microsomes .
19525446	0	Benzene	0,7	chondromodulin-I	45,61	Benzene	chondromodulin-I	MESH:D001554	11061	Chemical	Gene	up-regulates|amod|START_ENTITY END_ENTITY|nsubj|up-regulates	Benzene metabolite hydroquinone up-regulates chondromodulin-I and inhibits tube formation in human bone marrow endothelial cells .
25757908	0	Benzidine	0,9	ERK1/2	89,95	Benzidine	ERK1/2	MESH:C029876	5595;5594	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|pathway pathway|compound|END_ENTITY	Benzidine induces epithelial-mesenchymal transition in human uroepithelial cells through ERK1/2 pathway .
24461289	0	Benzimidazole	0,13	CB2	14,17	Benzimidazole	CB2	MESH:C031000	1269	Chemical	Gene	agonists|amod|START_ENTITY agonists|compound|END_ENTITY	Benzimidazole CB2 agonists : design , synthesis and SAR .
23058106	0	Benzimidazole	0,13	CHK2	47,51	Benzimidazole	CHK2	MESH:C031000	11200	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Benzimidazole inhibitors of the protein kinase CHK2 : clarification of the binding mode by flexible side chain docking and protein-ligand crystallography .
20078106	0	Benzimidazole	0,13	serotonin_5-HT6_receptor	33,57	Benzimidazole	serotonin 5-HT6 receptor	MESH:C031000	3362	Chemical	Gene	START_ENTITY|nmod|antagonists antagonists|amod|END_ENTITY	Benzimidazole derivatives as new serotonin_5-HT6_receptor antagonists .
16782335	0	Benzimidazole-2-carboxamides	0,28	NR2B	38,42	Benzimidazole-2-carboxamides	NR2B	null	14812(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|antagonists antagonists|nummod|END_ENTITY	Benzimidazole-2-carboxamides as novel NR2B selective NMDA receptor antagonists .
16204990	0	Benzimidazole-5-sulfonamides	0,28	LHRH	88,92	Benzimidazole-5-sulfonamides	LHRH	null	2796	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Benzimidazole-5-sulfonamides as novel nonpeptide luteinizing_hormone_releasing_hormone -LRB- LHRH -RRB- antagonists : minimization of mechanism-based CYP3A4 inhibition .
16204990	0	Benzimidazole-5-sulfonamides	0,28	luteinizing_hormone_releasing_hormone	49,86	Benzimidazole-5-sulfonamides	luteinizing hormone releasing hormone	null	2796	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|compound|END_ENTITY	Benzimidazole-5-sulfonamides as novel nonpeptide luteinizing_hormone_releasing_hormone -LRB- LHRH -RRB- antagonists : minimization of mechanism-based CYP3A4 inhibition .
25514817	0	Benzimidazole_Reverse_Amides	58,86	Pan	90,93	Benzimidazole Reverse Amides	Pan	null	51816	Chemical	Gene	START_ENTITY|nmod|Inhibitors Inhibitors|compound|END_ENTITY	Correction to Design and Synthesis of Orally Bioavailable Benzimidazole_Reverse_Amides as Pan RAF Kinase Inhibitors .
25900113	0	Benzimidazoles	4,18	Aurora_A_Kinase	52,67	Benzimidazoles	Aurora A Kinase	MESH:D001562	6790	Chemical	Gene	Effects|nsubj|START_ENTITY Effects|nmod|END_ENTITY	New Benzimidazoles and Their Antitumor Effects with Aurora_A_Kinase and KSP Inhibitory Activities .
15837306	0	Benzimidazoles	0,14	luteinizing_hormone-releasing_hormone	30,67	Benzimidazoles	luteinizing hormone-releasing hormone	MESH:D001562	2796	Chemical	Gene	START_ENTITY|nmod|antagonists antagonists|amod|END_ENTITY	Benzimidazoles as non-peptide luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- antagonists .
21733690	0	Benzimidazolone	0,15	chymase	26,33	Benzimidazolone	chymase	MESH:C014353	1215	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|compound|END_ENTITY	Benzimidazolone as potent chymase inhibitor : modulation of reactive metabolite formation in the hydrophobic -LRB- P1 -RRB- region .
24074637	0	Benzoate	0,8	D-amino_acid_oxidase	12,32	Benzoate	D-amino acid oxidase	MESH:D001565	1610	Chemical	Gene	inhibitor|advmod|START_ENTITY inhibitor|nsubj|END_ENTITY	Benzoate , a D-amino_acid_oxidase inhibitor , for the treatment of early-phase Alzheimer_disease : a randomized , double-blind , placebo-controlled trial .
11909725	0	Benzobicyclooctanes	0,19	TNF-alpha	43,52	Benzobicyclooctanes	TNF-alpha	null	7124	Chemical	Gene	START_ENTITY|nmod|signaling signaling|compound|END_ENTITY	Benzobicyclooctanes as novel inhibitors of TNF-alpha signaling .
1480515	0	Benzodiazepine	0,14	corticotropin-releasing_factor	30,60	Benzodiazepine	corticotropin-releasing factor	MESH:D001569	81648(Tax:10116)	Chemical	Gene	suppression|amod|START_ENTITY suppression|nmod|END_ENTITY	Benzodiazepine suppression of corticotropin-releasing_factor -LRB- CRF -RRB- - induced beta-endorphin release from rat neurointermediate pituitary .
16432175	0	Benzodiazepinedione	0,19	Hdm2	38,42	Benzodiazepinedione	Hdm2	null	4193	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Benzodiazepinedione inhibitors of the Hdm2 : p53 complex suppress human tumor cell proliferation in vitro and sensitize tumors to doxorubicin in vivo .
24836070	0	Benzofuran	0,10	mTOR	51,55	Benzofuran	mTOR	MESH:C105430	21977(Tax:10090)	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|inhibitors inhibitors|nmod|END_ENTITY	Benzofuran derivatives as anticancer inhibitors of mTOR signaling .
7518818	0	Benzomalvins	0,12	substance_P	18,29	Benzomalvins	substance P	null	6863	Chemical	Gene	START_ENTITY|appos|inhibitors inhibitors|compound|END_ENTITY	Benzomalvins , new substance_P inhibitors from a Penicillium sp .
27075927	0	Benzopyrene	0,11	IL8	97,100	Benzopyrene	IL8	null	3576	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Benzopyrene promotes lung_cancer A549 cell migration and invasion through up-regulating cytokine IL8 and chemokines CCL2 and CCL3 expression .
16546966	0	Benzoquinone	0,12	heat_shock_protein_90	23,44	Benzoquinone	heat shock protein 90	MESH:C004532	3320	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Benzoquinone ansamycin heat_shock_protein_90 inhibitors modulate multiple functions required for tumor angiogenesis .
16325333	0	Benzothiazole	0,13	11beta-hydroxysteroid_dehydrogenase_type_1	55,97	Benzothiazole	11beta-hydroxysteroid dehydrogenase type 1	MESH:C005465	3290	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Benzothiazole derivatives as novel inhibitors of human 11beta-hydroxysteroid_dehydrogenase_type_1 .
1324317	0	Benzothiazole_hydroxy_ureas	0,27	5-lipoxygenase	45,59	Benzothiazole hydroxy ureas	5-lipoxygenase	null	240	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Benzothiazole_hydroxy_ureas as inhibitors of 5-lipoxygenase : use of the hydroxyurea moiety as a replacement for hydroxamic_acid .
19616942	0	Benzothiophene	0,14	MK2	29,32	Benzothiophene	MK2	MESH:C088015	9261	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Benzothiophene inhibitors of MK2 .
19616945	0	Benzothiophene	0,14	MK2	29,32	Benzothiophene	MK2	MESH:C088015	9261	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Benzothiophene inhibitors of MK2 .
19786348	0	Benzoxazole_piperidines	0,23	somatostatin_receptor_subtype_5	48,79	Benzoxazole piperidines	somatostatin receptor subtype 5	null	25354(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|antagonists antagonists|amod|END_ENTITY	Benzoxazole_piperidines as selective and potent somatostatin_receptor_subtype_5 antagonists .
3641630	0	Benzoyl-kallikrein	1,19	kallikrein	21,31	Benzoyl-kallikrein	kallikrein	MESH:C050271	9622	Chemical	Gene	START_ENTITY|dep|activity activity|compound|END_ENTITY	-LSB- Benzoyl-kallikrein : kallikrein activity and kinin generation in plasma -RSB- .
21465666	0	Benzyl	0,6	autotaxin	59,68	Benzyl	autotaxin	CHEBI:22744	18606(Tax:10090)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Benzyl and naphthalene methylphosphonic acid inhibitors of autotaxin with anti-invasive and anti-metastatic activity .
25253661	0	Benzyl_isothiocyanate	0,21	IL-13	31,36	Benzyl isothiocyanate	IL-13	MESH:C031403	3596	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Benzyl_isothiocyanate inhibits IL-13 expression in human basophilic KU812 cells .
21163886	0	Benzyl_isothiocyanate	0,21	leptin	52,58	Benzyl isothiocyanate	leptin	MESH:C031403	3952	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|actions actions|nmod|END_ENTITY	Benzyl_isothiocyanate inhibits oncogenic actions of leptin in human breast_cancer cells by suppressing activation of signal_transducer_and_activator_of_transcription_3 .
20299216	0	Benzyl_prolinate	0,16	KCC2	48,52	Benzyl prolinate	KCC2	null	57468	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Benzyl_prolinate derivatives as novel selective KCC2 blockers .
8452516	0	Benzyloxycarbonyl-D-Phe-Pro-methoxypropylboroglycine	0,52	thrombin	75,83	Benzyloxycarbonyl-D-Phe-Pro-methoxypropylboroglycine	thrombin	null	2147	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	Benzyloxycarbonyl-D-Phe-Pro-methoxypropylboroglycine : a novel inhibitor of thrombin with high selectivity containing a neutral side chain at the P1 position .
23744435	0	Benzylpenicillin	0,16	OAT1	62,66	Benzylpenicillin	OAT1	MESH:D010400	9356	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Benzylpenicillin inhibits the renal_excretion of acyclovir by OAT1 and OAT3 .
8845811	0	Benzylphthalimides	0,18	tumor_necrosis_factor_alpha	97,124	Benzylphthalimides	tumor necrosis factor alpha	null	7124	Chemical	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	Benzylphthalimides and phenethylphthalimides with thalidomide-like activity on the production of tumor_necrosis_factor_alpha .
8344872	0	Bequinostatins_A_and_B	0,22	glutathione_S-transferase	41,66	Bequinostatins A and B	glutathione S-transferase	null	373156	Chemical	Gene	START_ENTITY|dobj|inhibitors inhibitors|nmod|END_ENTITY	Bequinostatins_A_and_B new inhibitors of glutathione_S-transferase , produced by Streptomyces sp .
23195898	0	Berbamine	0,9	IL-2_receptor	19,32	Berbamine	IL-2 receptor	MESH:C027870	3560	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Berbamine inhibits IL-2_receptor expression , but spares IL-2 production and its mRNA expression .
23732865	0	Berberine	0,9	AMPK	50,54	Berberine	AMPK	MESH:D001599	5563	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Berberine induces selective apoptosis through the AMPK - mediated mitochondrial/caspase pathway in hepatocellular_carcinoma .
24385682	0	Berberine	0,9	AMPK	102,106	Berberine	AMPK	MESH:D001599	5562	Chemical	Gene	protects|nsubj|START_ENTITY protects|dobj|involvements involvements|nmod|upregulation upregulation|nmod|END_ENTITY	Berberine protects against palmitate-induced endothelial_dysfunction : involvements of upregulation of AMPK and eNOS and downregulation of NOX4 .
24664781	0	Berberine	0,9	AMPK	83,87	Berberine	AMPK	MESH:D001599	78975(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|myocardial_apoptosis myocardial_apoptosis|nmod|END_ENTITY	Berberine reduces ischemia/reperfusion-induced myocardial_apoptosis via activating AMPK and PI3K-Akt signaling in diabetic rats .
25409232	0	Berberine	0,9	AMPK	56,60	Berberine	AMPK	MESH:D001599	5563	Chemical	Gene	Function|compound|START_ENTITY Function|nmod|Activation Activation|compound|END_ENTITY	Berberine Improves Kidney Function in Diabetic Mice via AMPK Activation .
26166377	0	Berberine	0,9	AMPK	152,156	Berberine	AMPK	MESH:D001599	5563	Chemical	Gene	inhibits|nsubj|START_ENTITY a|dep|inhibits a|dep|kB kB|nmod|activation activation|nmod|END_ENTITY	Berberine inhibits tumor_necrosis_factor __ - a - induced expression of inflammatory molecules and activation of nuclear factor - kB via the activation of AMPK in vascular endothelial cells .
26184498	0	Berberine	0,9	AMPK	127,131	Berberine	AMPK	MESH:D001599	78975(Tax:10116)	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|nmod|model model|nmod|signaling signaling|compound|END_ENTITY	Berberine prevents nitric_oxide-induced rat chondrocyte apoptosis and cartilage_degeneration in a rat osteoarthritis model via AMPK and p38 MAPK signaling .
26773864	0	Berberine	0,9	BDNF	27,31	Berberine	BDNF	MESH:D001599	12064(Tax:10090)	Chemical	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|compound|END_ENTITY	Berberine up-regulates the BDNF expression in hippocampus and attenuates corticosterone-induced depressive-like behavior in mice .
22155099	0	Berberine	0,9	COX-2	22,27	Berberine	COX-2	MESH:D001599	29527(Tax:10116)	Chemical	Gene	ameliorates|nsubj|START_ENTITY ameliorates|dobj|expression expression|compound|END_ENTITY	Berberine ameliorates COX-2 expression in rat small intestinal mucosa partially through PPARy pathway during acute endotoxemia .
23457600	0	Berberine	0,9	Cbl	107,110	Berberine	Cbl	MESH:D001599	867	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|activation activation|nmod|END_ENTITY	Berberine inhibits proliferation and down-regulates epidermal_growth_factor_receptor through activation of Cbl in colon_tumor cells .
16448624	0	Berberine	0,9	Egr-1	39,44	Berberine	Egr-1	MESH:D001599	24330(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	Berberine suppresses MEK/ERK-dependent Egr-1 signaling pathway and inhibits vascular smooth_muscle_cell regrowth after in vitro mechanical injury .
19403287	0	Berberine	0,9	GATA-2	34,40	Berberine	GATA-2	MESH:D001599	14461(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Berberine increases expression of GATA-2 and GATA-3 during inhibition of adipocyte differentiation .
15322253	0	Berberine	0,9	HIF-1alpha	19,29	Berberine	HIF-1alpha	MESH:D001599	3091	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Berberine inhibits HIF-1alpha expression via enhanced proteolysis .
18240344	0	Berberine	0,9	IKKbeta	101,108	Berberine	IKKbeta	MESH:D001599	3551	Chemical	Gene	reverses|nsubj|START_ENTITY reverses|advcl|targeting targeting|dobj|END_ENTITY	Berberine reverses free-fatty-acid-induced insulin resistance in 3T3-L1 adipocytes through targeting IKKbeta .
26344001	0	Berberine	0,9	IL-1b	34,39	Berberine	IL-1b	MESH:D001599	24494(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|amod|END_ENTITY	Berberine attenuates CCN2-induced IL-1b expression and prevents cartilage degradation in a rat model of osteoarthritis .
25496992	0	Berberine	0,9	Id-1	21,25	Berberine	Id-1	MESH:D001599	15901(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Berberine suppresses Id-1 expression and inhibits the growth and development of lung metastases in hepatocellular_carcinoma .
18164189	0	Berberine	0,9	MMP-1	30,35	Berberine	MMP-1	MESH:D001599	4312	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|dobj|END_ENTITY	Berberine prevents UV-induced MMP-1 and reduction of type_I_procollagen expression in human dermal fibroblasts .
22381172	0	Berberine	0,9	MMP-1	37,42	Berberine	MMP-1	MESH:D001599	4312	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	Berberine suppresses the TPA-induced MMP-1 and MMP-9 expressions through the inhibition of PKC-a in breast_cancer cells .
17951041	0	Berberine	0,9	MMP-9	31,36	Berberine	MMP-9	MESH:D001599	4318	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Berberine inhibits TPA-induced MMP-9 and IL-6 expression in normal human keratinocytes .
19052522	0	Berberine	0,9	MMP-9	39,44	Berberine	MMP-9	MESH:D001599	4318	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	Berberine suppresses TNF-alpha-induced MMP-9 and cell invasion through inhibition of AP-1 activity in MDA-MB-231 human breast_cancer cells .
19576641	0	Berberine	0,9	MMP-9	23,28	Berberine	MMP-9	MESH:D001599	4318	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|compound|END_ENTITY	Berberine reduces both MMP-9 and EMMPRIN expression through prevention of p38 pathway activation in PMA-induced macrophages .
17964072	0	Berberine	0,9	NAG-1	52,57	Berberine	NAG-1	MESH:D001599	9518	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Berberine , a natural isoquinoline_alkaloid , induces NAG-1 and ATF3 expression in human colorectal_cancer cells .
22668974	0	Berberine	0,9	NHE3	38,42	Berberine	NHE3	MESH:D001599	105243(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Berberine increases the expression of NHE3 and AQP4 in sennosideA-induced diarrhoea model .
18355829	0	Berberine	0,9	PCSK9	20,25	Berberine	PCSK9	MESH:D001599	255738	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|nummod|END_ENTITY	Berberine decreases PCSK9 expression in HepG2 cells .
23573121	0	Berberine	10,19	PPAR_a	23,29	Berberine	PPAR a	MESH:D001599	25747(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of Berberine on PPAR_a / NO Activation in High Glucose - and Insulin-Induced Cardiomyocyte Hypertrophy .
20515652	0	Berberine	0,9	PTP1B	19,24	Berberine	PTP1B	MESH:D001599	19246(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	Berberine inhibits PTP1B activity and mimics insulin action .
25279238	0	Berberine	44,53	Phosphoinositide_3-Kinase	102,127	Berberine	Phosphoinositide 3-Kinase	MESH:D001599	5293	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Inhibitory Effects of Isoquinoline Alkaloid Berberine on Ischemia-Induced Apoptosis via Activation of Phosphoinositide_3-Kinase / Protein Kinase B Signaling Pathway .
26503561	0	Berberine	0,9	STAT3	59,64	Berberine	STAT3	MESH:D001599	6774	Chemical	Gene	Sensitivity|compound|START_ENTITY Sensitivity|nmod|END_ENTITY	Berberine Increases Doxorubicin Sensitivity by Suppressing STAT3 in Lung_Cancer .
23085271	0	Berberine	0,9	TGF-b1	42,48	Berberine	TGF-b1	MESH:D001599	7040	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	Berberine suppresses high glucose-induced TGF-b1 and fibronectin synthesis in mesangial cells through inhibition of sphingosine_kinase_1 / AP-1 pathway .
19034703	0	Berberine	0,9	TNFalpha	37,45	Berberine	TNFalpha	MESH:D001599	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Berberine inhibits the expression of TNFalpha , MCP-1 , and IL-6 in AcLDL-stimulated macrophages through PPARgamma pathway .
24335171	0	Berberine	0,9	XIAP	74,78	Berberine	XIAP	MESH:D001599	331	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Berberine induces apoptosis in p53-null leukemia cells by down-regulating XIAP at the post-transcriptional level .
24335171	9	Berberine	875,884	XIAP	912,916	Berberine	XIAP	MESH:D001599	331	Chemical	Gene	induced|nsubj|START_ENTITY induced|dobj|down-regulation down-regulation|nmod|protein protein|compound|END_ENTITY	Berberine induced down-regulation of XIAP protein involving inhibition of MDM2 expression and a proteasome-dependent pathway .
21613449	0	Berberine	0,9	androgen_receptor	21,38	Berberine	androgen receptor	MESH:D001599	367	Chemical	Gene	suppresses|amod|START_ENTITY END_ENTITY|nsubj|suppresses	Berberine suppresses androgen_receptor signaling in prostate_cancer .
26142340	0	Berberine	0,9	caspase-3	93,102	Berberine	caspase-3	MESH:D001599	12367(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Berberine induces cell apoptosis through cytochrome C/apoptotic _ protease-activating_factor_1 / caspase-3 and apoptosis_inducing_factor pathway in mouse_insulinoma cells .
18430372	0	Berberine	0,9	cyclin_D1	19,28	Berberine	cyclin D1	MESH:D001599	595	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Berberine inhibits cyclin_D1 expression via suppressed binding of AP-1 transcription factors to CCND1 AP-1 motif .
20974686	0	Berberine	0,9	cyclooxygenase-2	108,124	Berberine	cyclooxygenase-2	MESH:D001599	5743	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|reducing reducing|dobj|expressions expressions|nmod|receptors receptors|amod|END_ENTITY	Berberine , an isoquinoline_alkaloid , inhibits melanoma_cancer cell migration by reducing the expressions of cyclooxygenase-2 , prostaglandin_E and prostaglandin_E receptors .
23457600	0	Berberine	0,9	epidermal_growth_factor_receptor	52,84	Berberine	epidermal growth factor receptor	MESH:D001599	1956	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Berberine inhibits proliferation and down-regulates epidermal_growth_factor_receptor through activation of Cbl in colon_tumor cells .
25394789	0	Berberine	0,9	epidermal_growth_factor_receptor	18,50	Berberine	epidermal growth factor receptor	MESH:D001599	1956	Chemical	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	Berberine targets epidermal_growth_factor_receptor signaling to suppress prostate_cancer proliferation in vitro .
18996945	0	Berberine	0,9	glucagon-like_peptide-1	19,42	Berberine	glucagon-like peptide-1	MESH:D001599	24952(Tax:10116)	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|amide amide|amod|END_ENTITY	Berberine promotes glucagon-like_peptide-1 -LRB- 7-36 -RRB- amide secretion in streptozotocin-induced diabetic rats .
20840879	0	Berberine	0,9	insulin	18,25	Berberine	insulin	MESH:D001599	3630	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|resistance resistance|compound|END_ENTITY	Berberine reduces insulin resistance induced by dexamethasone in theca cells in vitro .
25634589	0	Berberine	0,9	p38	49,52	Berberine	p38	MESH:D001599	1432	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|amod|END_ENTITY	Berberine induces FasL-related apoptosis through p38 activation in KB human oral_cancer cells .
21856447	0	Berberine	0,9	thymic_stromal_lymphopoietin	37,65	Berberine	thymic stromal lymphopoietin	MESH:D001599	85480	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|nmod|END_ENTITY	Berberine inhibits the production of thymic_stromal_lymphopoietin by the blockade of caspase-1 / NF-kB pathway in mast cells .
21641970	0	Berberine_hydrochloride	0,23	cyclooxygenase-2	35,51	Berberine hydrochloride	cyclooxygenase-2	null	29527(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|amod|END_ENTITY	Berberine_hydrochloride attenuates cyclooxygenase-2 expression in rat small intestinal mucosa during acute endotoxemia .
22705772	0	Bergamottin	0,11	CYP1A1	42,48	Bergamottin	CYP1A1	MESH:C068337	1543	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Bergamottin is a competitive inhibitor of CYP1A1 and is antimutagenic in the Ames test .
25130169	0	Bergamottin	0,11	STAT3	136,141	Bergamottin	STAT3	MESH:C068337	6774	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|inhibition inhibition|nmod|END_ENTITY	Bergamottin , a natural furanocoumarin obtained from grapefruit juice induces chemosensitization and apoptosis through the inhibition of STAT3 signaling pathway in tumor cells .
25104312	0	Beryllium	0,9	GSK-3b	38,44	Beryllium	GSK-3b	MESH:D001608	2932	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Beryllium is an inhibitor of cellular GSK-3b that is 1,000-fold more potent than lithium .
8977230	0	Beryllium	0,9	IL-2	18,22	Beryllium	IL-2	MESH:D001608	3558	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Beryllium induces IL-2 and IFN-gamma in berylliosis .
20549306	0	Beryllium_sulfate	0,17	CDKN1A	30,36	Beryllium sulfate	CDKN1A	MESH:C020711	1026	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Beryllium_sulfate induces p21 CDKN1A expression and a senescence-like cell cycle arrest in susceptible cancer cell types .
20549306	0	Beryllium_sulfate	0,17	p21	26,29	Beryllium sulfate	p21	MESH:C020711	1026	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Beryllium_sulfate induces p21 CDKN1A expression and a senescence-like cell cycle arrest in susceptible cancer cell types .
1912369	0	Bestatin	0,8	aminopeptidase	13,27	Bestatin	aminopeptidase	null	10404	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Bestatin , an aminopeptidase inhibitor with a multi-pharmacological function .
2613395	0	Bestatin	0,8	aminopeptidase_B	26,42	Bestatin	aminopeptidase B	null	6051	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Bestatin , an inhibitor of aminopeptidase_B , suppresses the proliferation and differentiation of human B-cells in vitro .
21114026	0	Beta-arrestin	1,14	AP-1	30,34	Beta-arrestin	AP-1	null	16476(Tax:10090)	Chemical	Gene	START_ENTITY|appos|activity activity|compound|END_ENTITY	-LSB- Beta-arrestin and NF-kappaB , AP-1 activity in peripheral blood mononuclear cells of guinea_pigs sensitized by trichloroethylene -RSB- .
21961413	0	Beta-carotene	1,14	BAX	56,59	Beta-carotene	BAX	MESH:D019207	581	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	-LSB- Beta-carotene regulates the expression of proapoptotic BAX and CAPN2 in HL-60 , U-937 and TF-1 - human acute_myeloid_leukemia cell lines ; microarray , RQ-PCR and Western Blot analysis -RSB- .
12566071	0	Beta-carotene	0,13	HO-1	37,41	Beta-carotene	HO-1	MESH:D019207	3162	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Beta-carotene suppresses UVA-induced HO-1 gene expression in cultured FEK4 .
7306604	0	Beta-cyanoalanine	1,18	lupin	39,44	Beta-cyanoalanine	lupin	null	51251	Chemical	Gene	synthase|nsubj|START_ENTITY synthase|nmod|END_ENTITY	-LSB- Beta-cyanoalanine synthase from white lupin : some catalytic properties -RSB- .
12355428	0	Beta-galactoside	0,16	Th2	69,72	Beta-galactoside	Th2	MESH:C007816	15111(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Beta-galactoside alpha2,3-sialyltransferase-I gene expression during Th2 but not Th1 differentiation : implications for core2-glycan formation on cell surface proteins .
19285044	0	Beta-hydroxybutyrate	0,20	GABA-transaminase	28,45	Beta-hydroxybutyrate	GABA-transaminase	MESH:D020155	81632(Tax:10116)	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|activity activity|amod|END_ENTITY	Beta-hydroxybutyrate alters GABA-transaminase activity in cultured astrocytes .
25239907	0	Beta-lactone	42,54	pancreatic_lipase	74,91	Beta-lactone	pancreatic lipase	CHEBI:52937	5406	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|nmod|END_ENTITY	Operon for biosynthesis of lipstatin , the Beta-lactone inhibitor of human pancreatic_lipase .
18847196	0	Beta-lactones	0,13	ClpP	40,44	Beta-lactones	ClpP	CHEBI:49043	8192	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Beta-lactones as specific inhibitors of ClpP attenuate the production of extracellular virulence factors of Staphylococcus_aureus .
6463094	0	Beta-phenyl_cysteine	0,20	aminopeptidase	32,46	Beta-phenyl cysteine	aminopeptidase	MESH:C042216	10404	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Beta-phenyl_cysteine : a leucine aminopeptidase inhibitor .
17603173	0	Beta-sitosterol	0,15	caspase-3	108,117	Beta-sitosterol	caspase-3	MESH:C025473	836	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Beta-sitosterol induces anti-proliferation and apoptosis in human leukemic U937 cells through activation of caspase-3 and induction of Bax/Bcl -2 ratio .
17408953	0	Beta-substituted_cyclohexanecarboxamide	0,39	cathepsin_K	40,51	Beta-substituted cyclohexanecarboxamide	cathepsin K	null	1513	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Beta-substituted_cyclohexanecarboxamide cathepsin_K inhibitors : modification of the 1,2-disubstituted _ aromatic core .
6141164	0	Beta-substituted_ethylamine	0,27	lysyl_oxidase	65,78	Beta-substituted ethylamine	lysyl oxidase	null	4015	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Beta-substituted_ethylamine derivatives as suicide inhibitors of lysyl_oxidase .
6744730	0	Beta-tricalcium_phosphate	0,25	bone_morphogenetic_protein	46,72	Beta-tricalcium phosphate	bone morphogenetic protein	MESH:C485817	649	Chemical	Gene	system|amod|START_ENTITY system|nmod|END_ENTITY	Beta-tricalcium_phosphate delivery system for bone_morphogenetic_protein .
19435355	0	Beta-triketone	0,14	p-hydroxyphenylpyruvate_dioxygenase	35,70	Beta-triketone	p-hydroxyphenylpyruvate dioxygenase	null	837168(Tax:3702)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Beta-triketone inhibitors of plant p-hydroxyphenylpyruvate_dioxygenase : modeling and comparative molecular field analysis of their interactions .
12033937	0	Beta-turn_Phe	0,13	CD4	43,46	Beta-turn Phe	CD4	null	920	Chemical	Gene	START_ENTITY|nmod|site site|nmod|END_ENTITY	Beta-turn_Phe in HIV-1 Env binding site of CD4 and CD4 mimetic miniprotein enhances Env binding affinity but is not required for activation of co-receptor/17b site .
18380559	0	Beta_tricalcium_phosphate	80,105	platelet-rich_plasma	10,30	Beta tricalcium phosphate	platelet-rich plasma	MESH:C485817	722	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|Effect Effect|nmod|END_ENTITY	Effect of platelet-rich_plasma on the healing of intrabony_defects treated with Beta_tricalcium_phosphate and expanded polytetrafluoroethylene membranes .
8570211	0	Betacellulin	0,12	epidermal_growth_factor_receptor	27,59	Betacellulin	epidermal growth factor receptor	MESH:C079778	13649(Tax:10090)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Betacellulin activates the epidermal_growth_factor_receptor and erbB-4 , and induces cellular response patterns distinct from those stimulated by epidermal growth factor or neuregulin-beta .
26596326	0	Betaine	0,7	butyrylcholinesterase	22,43	Betaine	butyrylcholinesterase	MESH:D001622	65036(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|activity activity|amod|END_ENTITY	Betaine increases the butyrylcholinesterase activity in rat plasma .
20143470	0	Betaine	0,7	toll-like_receptor_4	17,37	Betaine	toll-like receptor 4	MESH:D001622	29260(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Betaine inhibits toll-like_receptor_4 expression in rats with ethanol-induced liver_injury .
10493108	0	Betaxolol	0,9	beta1-adrenoceptor	13,31	Betaxolol	beta1-adrenoceptor	MESH:D015784	24925(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Betaxolol , a beta1-adrenoceptor antagonist , has an affinity for L-type Ca2 + channels .
12457871	0	Betaxolol	0,9	beta1-adrenoceptor	13,31	Betaxolol	beta1-adrenoceptor	MESH:D015784	24925(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Betaxolol , a beta1-adrenoceptor antagonist , protects a transient ischemic_injury of the retina .
26391061	0	Betulinic_acid	0,14	PPAR-y	65,71	Betulinic acid	PPAR-y	MESH:C002070	5468	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|activating activating|dobj|END_ENTITY	Betulinic_acid inhibits IL-1b-induced inflammation by activating PPAR-y in human osteoarthritis chondrocytes .
19937797	0	Betulinic_acid	0,14	STAT3	26,31	Betulinic acid	STAT3	MESH:C002070	6774	Chemical	Gene	suppresses|amod|START_ENTITY END_ENTITY|nsubj|suppresses	Betulinic_acid suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase SHP-1 in human multiple_myeloma cells .
22553354	0	Betulinic_acid	0,14	YY1	23,26	Betulinic acid	YY1	MESH:C002070	7528	Chemical	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Betulinic_acid targets YY1 and ErbB2 through cannabinoid receptor-dependent disruption of microRNA-27a : ZBTB10 in breast_cancer .
16964520	0	Betulinic_acid	0,14	bcl-2	39,44	Betulinic acid	bcl-2	MESH:C002070	596	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|nmod|END_ENTITY	Betulinic_acid decreases expression of bcl-2 and cyclin_D1 , inhibits proliferation , migration and induces apoptosis in cancer cells .
26542288	0	Betulinic_acid	0,14	lipoprotein_lipase	68,86	Betulinic acid	lipoprotein lipase	MESH:C002070	4023	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|nmod|END_ENTITY	Betulinic_acid downregulates expression of oxidative stress-induced lipoprotein_lipase via the PKC/ERK/c-Fos pathway in RAW264 .7 macrophages .
22114077	0	Betulinic_acid	0,14	pancreatic_lipase	43,60	Betulinic acid	pancreatic lipase	MESH:C002070	25702(Tax:10116)	Chemical	Gene	has|nsubj|START_ENTITY has|dobj|effect effect|nmod|END_ENTITY	Betulinic_acid has an inhibitory effect on pancreatic_lipase and induces adipocyte lipolysis .
17483357	0	Bexarotene	0,10	retinoid_X_receptor	45,64	Bexarotene	retinoid X receptor	MESH:C095105	6256	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Bexarotene -LRB- LGD1069 , Targretin -RRB- , a selective retinoid_X_receptor agonist , prevents and reverses gemcitabine resistance in NSCLC cells by modulating gene amplification .
21816645	0	Bezafibrate	0,11	carnitine_palmitoyltransferase_II	24,57	Bezafibrate	carnitine palmitoyltransferase II	MESH:D001629	1376	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Bezafibrate upregulates carnitine_palmitoyltransferase_II expression and promotes mitochondrial_energy_crisis_dissipation in fibroblasts of patients with influenza-associated encephalopathy .
25360162	0	Bezafibrate	0,11	insulin	21,28	Bezafibrate	insulin	MESH:D001629	3630	Chemical	Gene	improves|nsubj|START_ENTITY improves|dobj|resistance resistance|compound|END_ENTITY	Bezafibrate improves insulin resistance evaluated using the glucose clamp technique in patients with type_2_diabetes_mellitus : a small-scale clinical study .
11292061	0	Bezafibrate	0,11	plasminogen_activator_inhibitor-1	45,78	Bezafibrate	plasminogen activator inhibitor-1	MESH:D001629	5054	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|overexpression overexpression|nmod|RNA RNA|amod|END_ENTITY	Bezafibrate attenuates the overexpression of plasminogen_activator_inhibitor-1 messenger RNA by a combination of mono-unsaturated_fatty_acid and insulin in hepG2 cells .
20400680	0	Bezafibrate	0,11	plasminogen_activator_inhibitor-1	20,53	Bezafibrate	plasminogen activator inhibitor-1	MESH:D001629	18787(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Bezafibrate induces plasminogen_activator_inhibitor-1 gene expression in a CLOCK-dependent circadian manner .
25907960	0	Bh3	0,3	Bcl-Xl	38,44	Bh3	Bcl-Xl	MESH:C006008	598	Chemical	Gene	changes|amod|START_ENTITY changes|nmod|END_ENTITY	Bh3 induced conformational changes in Bcl-Xl revealed by crystal structure and comparative analysis .
24002700	0	Bi2S3	43,48	CO2	81,84	Bi2S3	CO2	null	717	Chemical	Gene	START_ENTITY|nmod|reduction reduction|nmod|END_ENTITY	Shape-controlled solvothermal synthesis of Bi2S3 for photocatalytic reduction of CO2 to methyl_formate in methanol .
16202583	0	Biaryl_diamides	0,15	melanin_concentrating_hormone_receptor_1	26,66	Biaryl diamides	melanin concentrating hormone receptor 1	null	2847	Chemical	Gene	START_ENTITY|nmod|antagonists antagonists|amod|END_ENTITY	Biaryl_diamides as potent melanin_concentrating_hormone_receptor_1 antagonists .
17914091	0	Bicalutamide	0,12	Her2	50,54	Bicalutamide	Her2	MESH:C053541	2064	Chemical	Gene	increases|nsubj|START_ENTITY increases|nmod|END_ENTITY	Bicalutamide increases phospho-Akt levels through Her2 in patients with prostate_cancer .
12015321	0	Bicalutamide	0,12	androgen_receptor	29,46	Bicalutamide	androgen receptor	MESH:C053541	367	Chemical	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	Bicalutamide functions as an androgen_receptor antagonist by assembly of a transcriptionally inactive receptor .
22711878	0	Bicarbonate	0,11	CFTR	27,31	Bicarbonate	CFTR	CHEBI:17544	12638(Tax:10090)	Chemical	Gene	channel|amod|START_ENTITY channel|amod|END_ENTITY	Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus phenotype .
26674864	0	Bicarbonate	54,65	CLH-1	114,119	Bicarbonate	CLH-1	CHEBI:17544	174821(Tax:6239)	Chemical	Gene	Transport|compound|START_ENTITY Transport|nmod|END_ENTITY	A Novel Mechanism of pH Buffering in C. _ elegans Glia : Bicarbonate Transport via the Voltage-Gated ClC Cl - Channel CLH-1 .
25767116	0	Bicarbonate	0,11	ROS-GC	55,61	Bicarbonate	ROS-GC	CHEBI:17544	3000	Chemical	Gene	Cyclase|compound|START_ENTITY Cyclase|appos|END_ENTITY	Bicarbonate Modulates Photoreceptor Guanylate Cyclase -LRB- ROS-GC -RRB- Catalytic Activity .
6245584	0	Bicarbonate	0,11	parathyroid_hormone	53,72	Bicarbonate	parathyroid hormone	CHEBI:17544	5741	Chemical	Gene	transport|amod|START_ENTITY transport|dep|effect effect|nmod|END_ENTITY	Bicarbonate transport by proximal tubules : effect of parathyroid_hormone and dibutyryl_cyclic_AMP .
176080	0	Bicarbonate	0,11	secretin	107,115	Bicarbonate	secretin	CHEBI:17544	6343	Chemical	Gene	content|compound|START_ENTITY juice|nsubj|content juice|nmod|doses doses|nmod|END_ENTITY	Bicarbonate and cyclic_AMP content of pure human pancreatic juice in response to graded doses of synthetic secretin .
8382644	0	Bicarbonate	0,11	vasoactive_intestinal_polypeptide	61,94	Bicarbonate	vasoactive intestinal polypeptide	CHEBI:17544	100352512(Tax:9986)	Chemical	Gene	transport|amod|START_ENTITY transport|dep|effect effect|nmod|END_ENTITY	Bicarbonate transport by rabbit duodenum in vitro : effect of vasoactive_intestinal_polypeptide , prostaglandin_E2 , and cyclic_adenosine_monophosphate .
8978834	0	Bicyclic_N-hydroxyurea	0,22	5-lipoxygenase	37,51	Bicyclic N-hydroxyurea	5-lipoxygenase	null	11689(Tax:10090)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Bicyclic_N-hydroxyurea inhibitors of 5-lipoxygenase : pharmacodynamic , pharmacokinetic , and in vitro metabolic studies characterizing N-hydroxy-N - -LRB- 2,3-dihydro-6 - -LRB- phenylmethoxy -RRB- -3 - benzofuranyl -RRB- urea .
16303309	0	Bicyclic_and_tricyclic_thiophenes	0,33	protein_tyrosine_phosphatase_1B	37,68	Bicyclic and tricyclic thiophenes	protein tyrosine phosphatase 1B	null	5770	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Bicyclic_and_tricyclic_thiophenes as protein_tyrosine_phosphatase_1B inhibitors .
24252362	0	Bicyclol	0,8	HO-1	48,52	Bicyclol	HO-1	MESH:C477843	24451(Tax:10116)	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|Nrf2 Nrf2|appos|expression expression|compound|END_ENTITY	Bicyclol upregulates transcription factor Nrf2 , HO-1 expression and protects rat brains against focal ischemia .
24252362	0	Bicyclol	0,8	Nrf2	42,46	Bicyclol	Nrf2	MESH:C477843	83619(Tax:10116)	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	Bicyclol upregulates transcription factor Nrf2 , HO-1 expression and protects rat brains against focal ischemia .
26345941	0	Bifidobacterium	10,25	TRAF6	59,64	Bifidobacterium	TRAF6	null	311245(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|nmod|END_ENTITY	Effect of Bifidobacterium on the mRNA expression levels of TRAF6 , GSK-3b , and microRNA-146a in LPS-stimulated rat intestinal epithelial cells .
26345941	0	Bifidobacterium	10,25	TRAF6	59,64	Bifidobacterium	TRAF6	null	311245(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|nmod|END_ENTITY	Effect of Bifidobacterium on the mRNA expression levels of TRAF6 , GSK-3b , and microRNA-146a in LPS-stimulated rat intestinal epithelial cells .
16644528	0	Biflavonoids	0,12	phosphatase_of_regenerating_liver-3	23,58	Biflavonoids	phosphatase of regenerating liver-3	MESH:D044946	11156	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|dobj|END_ENTITY	Biflavonoids inhibited phosphatase_of_regenerating_liver-3 -LRB- PRL-3 -RRB- .
25619393	0	Bigelovin	0,9	STAT3	19,24	Bigelovin	STAT3	MESH:C099796	6774	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Bigelovin inhibits STAT3 signaling by inactivating JAK2 and induces apoptosis in human cancer cells .
26374826	0	Bile_Acid	145,154	CYP27A1	133,140	Bile Acid	CYP27A1	CHEBI:3098	1593	Chemical	Gene	Pathway|compound|START_ENTITY END_ENTITY|nmod|Pathway	Synthesis of an Endogenous Steroidal Na Pump Inhibitor Marinobufagenin , Implicated in Human Cardiovascular_Diseases , Is Initiated by CYP27A1 via Bile_Acid Pathway .
24728076	0	Bile_Acid	31,40	FGF19	83,88	Bile Acid	FGF19	CHEBI:3098	9965	Chemical	Gene	Activity|compound|START_ENTITY Activity|nmod|END_ENTITY	Separating Tumorigenicity from Bile_Acid Regulatory Activity for Endocrine Hormone FGF19 .
25138215	0	Bile_Acid	53,62	FXR	85,88	Bile Acid	FXR	CHEBI:3098	20186(Tax:10090)	Chemical	Gene	Farnesoid_X_Receptor|compound|START_ENTITY Regulation|nmod|Farnesoid_X_Receptor Regulation|appos|END_ENTITY	Transcriptional Regulation of the Intestinal Nuclear Bile_Acid Farnesoid_X_Receptor -LRB- FXR -RRB- by the caudal-related_Homeobox_2 -LRB- CDX2 -RRB- .
25405617	0	Bile_Acid	30,39	FXR	49,52	Bile Acid	FXR	CHEBI:3098	60351(Tax:10116)	Chemical	Gene	Agonist|compound|START_ENTITY Agonist|compound|END_ENTITY	Effects of Bile_Acids and the Bile_Acid Receptor FXR Agonist on the Respiratory Rhythm in the In Vitro Brainstem Medulla Slice of Neonatal Sprague-Dawley_Rats .
26501563	0	Bile_Acid	43,52	FXR	24,27	Bile Acid	FXR	CHEBI:3098	9971	Chemical	Gene	Homeostasis|nsubj|START_ENTITY Target|dep|Homeostasis Target|nmod|END_ENTITY	MafG , A Novel Target of FXR that Regulates Bile_Acid Homeostasis .
25162837	1	Bile_Acid	145,154	GP-BAR1	167,174	Bile Acid	GP-BAR1	CHEBI:3098	151306	Chemical	Gene	START_ENTITY|dobj|Receptor Receptor|appos|END_ENTITY	Discovery of Bile_Acid Derivatives As Selective Agonists of Cell-Surface G-Protein Coupled Bile_Acid Receptor 1 -LRB- GP-BAR1 -RRB- .
25162837	1	Bile_Acid	67,76	GP-BAR1	167,174	Bile Acid	GP-BAR1	CHEBI:3098	151306	Chemical	Gene	Derivatives|compound|START_ENTITY Discovery|nmod|Derivatives Bile_Acid|nsubj|Discovery Bile_Acid|dobj|Receptor Receptor|appos|END_ENTITY	Discovery of Bile_Acid Derivatives As Selective Agonists of Cell-Surface G-Protein Coupled Bile_Acid Receptor 1 -LRB- GP-BAR1 -RRB- .
25411721	0	Bile_Acid	18,27	GPBAR1	40,46	Bile Acid	GPBAR1	CHEBI:3098	227289(Tax:10090)	Chemical	Gene	Receptor|compound|START_ENTITY Receptor|appos|END_ENTITY	G-Protein-Coupled Bile_Acid Receptor 1 -LRB- GPBAR1 , TGR5 -RRB- Agonists Reduce the Production of Proinflammatory Cytokines and Stabilize the Alternative Macrophage Phenotype .
12187295	0	Bile_Acid	71,80	Ntcp	95,99	Bile Acid	Ntcp	CHEBI:3098	24777(Tax:10116)	Chemical	Gene	Transporters|compound|START_ENTITY Expression|nmod|Transporters Ursodeoxycholic_Acid|nmod|Expression Effect|nmod|Ursodeoxycholic_Acid Effect|dep|END_ENTITY	Effect of Ursodeoxycholic_Acid on the Expression of the Hepatocellular Bile_Acid Transporters -LRB- Ntcp and bsep -RRB- in Rats With Estrogen-Induced Cholestasis .
25411721	0	Bile_Acid	18,27	TGR5	48,52	Bile Acid	TGR5	CHEBI:3098	227289(Tax:10090)	Chemical	Gene	Receptor|compound|START_ENTITY Receptor|appos|GPBAR1 GPBAR1|dep|END_ENTITY	G-Protein-Coupled Bile_Acid Receptor 1 -LRB- GPBAR1 , TGR5 -RRB- Agonists Reduce the Production of Proinflammatory Cytokines and Stabilize the Alternative Macrophage Phenotype .
26045264	0	Bile_Acid	4,13	TGR5	23,27	Bile Acid	TGR5	CHEBI:3098	227289(Tax:10090)	Chemical	Gene	Receptor|compound|START_ENTITY Receptor|dep|END_ENTITY	The Bile_Acid Receptor TGR5 and Liver_Regeneration .
26424786	0	Bile_Acid	18,27	TGR5	37,41	Bile Acid	TGR5	CHEBI:3098	227289(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|Kidney_Disease Kidney_Disease|compound|END_ENTITY	G Protein-Coupled Bile_Acid Receptor TGR5 Activation Inhibits Kidney_Disease in Obesity and Diabetes .
26696888	0	Bile_Acid	22,31	TGR5	49,53	Bile Acid	TGR5	CHEBI:3098	227289(Tax:10090)	Chemical	Gene	Gpbar1|compound|START_ENTITY Gpbar1|appos|END_ENTITY	The G-Protein-Coupled Bile_Acid Receptor Gpbar1 -LRB- TGR5 -RRB- Inhibits Gastric_Inflammation Through Antagonizing NF-kB Signaling Pathway .
18775915	0	Bile_acid	0,9	CDX1_and_orphan_nuclear_receptor_SHP	83,119	Bile acid	CDX1 and orphan nuclear receptor SHP	CHEBI:3098	1044;8431	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Bile_acid induces expression of COX-2 through the homeodomain transcription factor CDX1_and_orphan_nuclear_receptor_SHP in human gastric_cancer cells .
15817812	0	Bile_acid	0,9	FXR	28,31	Bile acid	FXR	CHEBI:3098	20186(Tax:10090)	Chemical	Gene	START_ENTITY|xcomp|signaling signaling|nmod|END_ENTITY	Bile_acid signaling through FXR induces intracellular adhesion molecule-1 expression in mouse liver and human hepatocytes .
26579439	0	Bile_acid	0,9	FXR	27,30	Bile acid	FXR	CHEBI:3098	9971	Chemical	Gene	receptor|amod|START_ENTITY END_ENTITY|nsubj|receptor	Bile_acid nuclear receptor FXR and digestive_system_diseases .
25735208	0	Bile_acid	108,117	GP-BAR1	130,137	Bile acid	GP-BAR1	CHEBI:3098	151306	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Stereoselective synthesis , biological evaluation , and modeling of novel bile_acid-derived G-protein coupled Bile_acid receptor 1 -LRB- GP-BAR1 , TGR5 -RRB- agonists .
23614904	0	Bile_acid	0,9	HMG-CoA_reductase	46,63	Bile acid	HMG-CoA reductase	CHEBI:3098	15357(Tax:10090)	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|nmod|END_ENTITY	Bile_acid and sterol metabolism with combined HMG-CoA_reductase and PCSK9 suppression .
7986821	0	Bile_acid	0,9	HMG-CoA_reductase	18,35	Bile acid	HMG-CoA reductase	CHEBI:3098	25675(Tax:10116)	Chemical	Gene	derived|nsubj|START_ENTITY derived|dobj|inhibitors inhibitors|amod|END_ENTITY	Bile_acid derived HMG-CoA_reductase inhibitors .
25475007	0	Bile_acid	0,9	MUC2	18,22	Bile acid	MUC2	CHEBI:3098	4583	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Bile_acid induces MUC2 expression and inhibits tumor invasion in gastric_carcinomas .
23619297	0	Bile_acid	0,9	TGR5	19,23	Bile acid	TGR5	CHEBI:3098	151306	Chemical	Gene	agonism|compound|START_ENTITY agonism|compound|END_ENTITY	Bile_acid receptor TGR5 agonism induces NO production and reduces monocyte adhesion in vascular endothelial cells .
25735208	0	Bile_acid	108,117	TGR5	139,143	Bile acid	TGR5	CHEBI:3098	151306	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|GP-BAR1 GP-BAR1|dep|END_ENTITY	Stereoselective synthesis , biological evaluation , and modeling of novel bile_acid-derived G-protein coupled Bile_acid receptor 1 -LRB- GP-BAR1 , TGR5 -RRB- agonists .
18307978	0	Bile_acid	0,9	c-Jun	20,25	Bile acid	c-Jun	CHEBI:3098	3725	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Bile_acid regulates c-Jun expression through the orphan nuclear receptor SHP induction in gastric cells .
20868235	0	Bile_acid	0,9	farnesoid-X-receptor	57,77	Bile acid	farnesoid-X-receptor	CHEBI:3098	20186(Tax:10090)	Chemical	Gene	retention|amod|START_ENTITY retention|nmod|END_ENTITY	Bile_acid retention and activation of endogenous hepatic farnesoid-X-receptor in the pathogenesis of fatty_liver disease in ob/ob-mice .
15317466	0	Bile_acid	0,9	farnesoid_X_receptor	40,60	Bile acid	farnesoid X receptor	CHEBI:3098	9971	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Bile_acid derivatives as ligands of the farnesoid_X_receptor .
16156672	0	Bile_acid	0,9	sister_of_P-glycoprotein	23,47	Bile acid	sister of P-glycoprotein	CHEBI:3098	27413(Tax:10090)	Chemical	Gene	transport|amod|START_ENTITY transport|nmod|END_ENTITY	Bile_acid transport in sister_of_P-glycoprotein -LRB- ABCB11 -RRB- knockout mice .
18922143	0	Bile_acids	0,10	CCN2	18,22	Bile acids	CCN2	MESH:D001647	1490	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|production production|compound|END_ENTITY	Bile_acids induce CCN2 production through p38_MAP_kinase activation in human bronchial epithelial cells : a factor contributing to airway fibrosis .
24993131	0	Bile_acids	0,10	CFTR	48,52	Bile acids	CFTR	MESH:D001647	1080	Chemical	Gene	stimulate|nsubj|START_ENTITY stimulate|nmod|END_ENTITY	Bile_acids stimulate chloride secretion through CFTR and calcium-activated Cl - channels in Calu-3 airway epithelial cells .
26568294	0	Bile_acids	0,10	Delta-like_1	18,30	Bile acids	Delta-like 1	MESH:D001647	28514	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|compound|END_ENTITY	Bile_acids induce Delta-like_1 expression via Cdx2-dependent pathway in the development of Barrett 's _ esophagus .
16710050	0	Bile_acids	0,10	PKCalpha	21,29	Bile acids	PKCalpha	MESH:D001647	5578	Chemical	Gene	autophosphorylation|compound|START_ENTITY autophosphorylation|compound|END_ENTITY	Bile_acids stimulate PKCalpha autophosphorylation and activation : role in the attenuation of prostaglandin_E1-induced cAMP production in human dermal fibroblasts .
16168958	0	Bile_acids	0,10	SR-BI	18,23	Bile acids	SR-BI	MESH:D001647	949	Chemical	Gene	reduce|nsubj|START_ENTITY reduce|dobj|expression expression|amod|END_ENTITY	Bile_acids reduce SR-BI expression in hepatocytes by a pathway involving FXR/RXR , SHP , and LRH-1 .
20104269	0	Bile_acids	0,10	cdx2	18,22	Bile acids	cdx2	MESH:D001647	66019(Tax:10116)	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|amod|END_ENTITY	Bile_acids induce cdx2 expression through the farnesoid_x_receptor in gastric epithelial cells .
16729332	0	Bile_acids	0,10	cholesterol_7_alpha-hydroxylase	43,74	Bile acids	cholesterol 7 alpha-hydroxylase	MESH:D001647	1581	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|gene gene|amod|END_ENTITY	Bile_acids and cytokines inhibit the human cholesterol_7_alpha-hydroxylase gene via the JNK/c-jun pathway in human liver cells .
2227820	0	Bile_acids	0,10	cholesterol_7_alpha-hydroxylase	112,143	Bile acids	cholesterol 7 alpha-hydroxylase	MESH:D001647	448985(Tax:9823)	Chemical	Gene	exert|nsubj|START_ENTITY exert|nmod|suppression suppression|nmod|activity activity|amod|END_ENTITY	Bile_acids exert negative feedback control on bile_acid synthesis in cultured pig hepatocytes by suppression of cholesterol_7_alpha-hydroxylase activity .
19085950	0	Bile_acids	0,10	cholesterol_7alpha-hydroxylase	90,120	Bile acids	cholesterol 7alpha-hydroxylase	MESH:D001647	1581	Chemical	Gene	activate|nsubj|START_ENTITY activate|dobj|fibroblast_growth_factor_19 fibroblast_growth_factor_19|acl|signaling signaling|xcomp|inhibit inhibit|dobj|expression expression|amod|END_ENTITY	Bile_acids activate fibroblast_growth_factor_19 signaling in human hepatocytes to inhibit cholesterol_7alpha-hydroxylase gene expression .
11910351	0	Bile_acids	0,10	cyclooxygenase-2	18,34	Bile acids	cyclooxygenase-2	MESH:D001647	5743	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|amod|END_ENTITY	Bile_acids induce cyclooxygenase-2 expression via the epidermal_growth_factor_receptor in a human cholangiocarcinoma cell line .
14656949	0	Bile_acids	0,10	cyclooxygenase-2	18,34	Bile acids	cyclooxygenase-2	MESH:D001647	5743	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|amod|END_ENTITY	Bile_acids induce cyclooxygenase-2 expression in human pancreatic_cancer cell lines .
8639615	0	Bile_salt	0,9	cholesterol_esterase	21,41	Bile salt	cholesterol esterase	CHEBI:3098	1056	Chemical	Gene	uptake|compound|START_ENTITY uptake|amod|END_ENTITY	Bile_salt stimulated cholesterol_esterase increases uptake of high density lipoprotein-associated cholesteryl_esters by HepG2 cells .
9108320	0	Bile_salt	0,9	cholesterol_esterase	30,50	Bile salt	cholesterol esterase	CHEBI:3098	1056	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Bile_salt activation of human cholesterol_esterase does not require protein dimerisation .
14983033	0	Bilirubin	0,9	Mrp1	142,146	Bilirubin	Mrp1	MESH:D001663	17250(Tax:10090)	Chemical	Gene	protects|nsubj|START_ENTITY protects|advcl|inducing inducing|dobj|up-regulation up-regulation|nmod|multidrug_resistance-associated_protein_1 multidrug_resistance-associated_protein_1|appos|END_ENTITY	Bilirubin protects astrocytes from its own toxicity by inducing up-regulation and translocation of multidrug_resistance-associated_protein_1 -LRB- Mrp1 -RRB- .
25147562	0	Bilirubin	29,38	PPARa	0,5	Bilirubin	PPARa	MESH:D001663	5465	Chemical	Gene	Homeostasis|compound|START_ENTITY Regulator|nmod|Homeostasis END_ENTITY|dep|Regulator	PPARa : A Master Regulator of Bilirubin Homeostasis .
10206734	0	Bilirubin	0,9	cytokeratin_18	30,44	Bilirubin	cytokeratin 18	MESH:D001663	16668(Tax:10090)	Chemical	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Bilirubin binding activity of cytokeratin_18 isolated from the porcine liver .
16129699	0	Bilirubin	0,9	nos2	20,24	Bilirubin	nos2	MESH:D001663	24599(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|amod|END_ENTITY	Bilirubin decreases nos2 expression via inhibition of NAD -LRB- P -RRB- H oxidase : implications for protection against endotoxic_shock in rats .
24814708	0	Biliverdin	0,10	C5aR	39,43	Biliverdin	C5aR	MESH:D001664	728	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	Biliverdin modulates the expression of C5aR in response to endotoxin in part via mTOR signaling .
17683071	0	Biliverdin	0,10	NF-kappaB	34,43	Biliverdin	NF-kappaB	MESH:D001664	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	Biliverdin inhibits activation of NF-kappaB : reversal of inhibition by human biliverdin reductase .
22042868	0	Biliverdin	0,10	Toll-like_receptor-4	20,40	Biliverdin	Toll-like receptor-4	MESH:D001664	21898(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Biliverdin inhibits Toll-like_receptor-4 -LRB- TLR4 -RRB- expression through nitric_oxide-dependent nuclear translocation of biliverdin reductase .
11263262	0	Bilobalide	0,10	glial_cell_line-derived_neurotrophic_factor	34,77	Bilobalide	glial cell line-derived neurotrophic factor	MESH:C073710	25453(Tax:10116)	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|nmod|END_ENTITY	Bilobalide promotes expression of glial_cell_line-derived_neurotrophic_factor and vascular_endothelial_growth_factor in rat astrocytes .
26622605	0	Bilobol	0,7	RhoA	79,83	Bilobol	RhoA	MESH:C064011	387	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Bilobol inhibits the lipopolysaccharide-induced expression and distribution of RhoA in HepG2 human hepatocellular_carcinoma cells .
26925841	0	Binimetinib	0,11	MEK	21,24	Binimetinib	MEK	MESH:C581313	5609	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Binimetinib inhibits MEK and is effective against neuroblastoma_tumor cells with low NF1 expression .
20818983	0	Biochanin_A	0,11	p75NTR	33,39	Biochanin A	p75NTR	MESH:C004541	4804	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|amod|END_ENTITY	Biochanin_A reduces drug-induced p75NTR expression and enhances cell survival : a new in vitro assay for screening inhibitors of p75NTR expression .
26874643	0	Biodentine	0,10	TRPA1	55,60	Biodentine	TRPA1	MESH:C506393	8989	Chemical	Gene	START_ENTITY|dobj|Expression Expression|compound|END_ENTITY	Biodentine Reduces Tumor_Necrosis_Factor_Alpha-induced TRPA1 Expression in Odontoblastlike Cells .
12485947	0	Bioflavonoid	0,12	multidrug_resistance_protein_1	65,95	Bioflavonoid	multidrug resistance protein 1	null	4363	Chemical	Gene	stimulation|amod|START_ENTITY stimulation|nmod|END_ENTITY	Bioflavonoid stimulation of glutathione transport by the 190-kDa multidrug_resistance_protein_1 -LRB- MRP1 -RRB- .
21290151	0	Biopterin	0,9	PARK8	61,66	Biopterin	PARK8	MESH:D001708	120892	Chemical	Gene	levels|compound|START_ENTITY levels|nmod|patients patients|nmod|END_ENTITY	Biopterin levels in the cerebrospinal fluid of patients with PARK8 -LRB- I2020T -RRB- .
10499515	0	Biotin	0,6	glucokinase	32,43	Biotin	glucokinase	MESH:D001710	24385(Tax:10116)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Biotin regulation of pancreatic glucokinase and insulin in primary cultured rat islets and in biotin-deficient rats .
19560332	0	Biotin	0,6	glucokinase	17,28	Biotin	glucokinase	MESH:D001710	24385(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Biotin increases glucokinase expression via soluble guanylate cyclase/protein kinase G , adenosine_triphosphate production and autocrine action of insulin in pancreatic rat islets .
20592104	0	Biotin	0,6	holocarboxylase_synthetase	35,61	Biotin	holocarboxylase synthetase	MESH:D001710	3141	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Biotin regulates the expression of holocarboxylase_synthetase in the miR-539 pathway in HEK-293 cells .
7417395	0	Biotin	0,6	pyruvate_carboxylase	21,41	Biotin	pyruvate carboxylase	MESH:D001710	5091	Chemical	Gene	status|compound|START_ENTITY status|appos|END_ENTITY	Biotin status , blood pyruvate_carboxylase -LRB- EC 6.4.1.1 -RRB- activity and performance in broilers under different conditions of bird husbandry and diet processing .
15166146	0	Bipartite	0,9	epidermal_growth_factor_receptor	35,67	Bipartite	epidermal growth factor receptor	null	37455(Tax:7227)	Chemical	Gene	inhibition|amod|START_ENTITY END_ENTITY|nsubj|inhibition	Bipartite inhibition of Drosophila epidermal_growth_factor_receptor by the extracellular and transmembrane domains of Kekkon1 .
21820769	0	Biphenyl-3-yl_alkylcarbamates	0,29	fatty_acid_amide_hydrolase	33,59	Biphenyl-3-yl alkylcarbamates	fatty acid amide hydrolase	null	29347(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Biphenyl-3-yl_alkylcarbamates as fatty_acid_amide_hydrolase -LRB- FAAH -RRB- inhibitors : steric effects of N-alkyl chain on rat plasma and liver stability .
25250725	0	Biphenyl_Substituted_Iminosugars	34,66	Glucosylceramide_Synthase	84,109	Biphenyl Substituted Iminosugars	Glucosylceramide Synthase	null	7357	Chemical	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification and Development of Biphenyl_Substituted_Iminosugars as Improved Dual Glucosylceramide_Synthase / Neutral Glucosylceramidase Inhibitors .
17981461	0	Biphenyl_amide	0,14	p38	15,18	Biphenyl amide	p38	null	1432	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Biphenyl_amide p38 kinase inhibitors 2 : Optimisation and SAR .
18006306	0	Biphenyl_amide	0,14	p38	15,18	Biphenyl amide	p38	null	1432	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Biphenyl_amide p38 kinase inhibitors 1 : Discovery and binding mode .
18242991	0	Biphenylsulfonyl-thiophene-carboxamidine	0,40	C1s	80,83	Biphenylsulfonyl-thiophene-carboxamidine	C1s	null	716	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s .
8918061	0	Bipyridyl_dihydrochloride	0,25	tumor_necrosis_factor-alpha	35,62	Bipyridyl dihydrochloride	tumor necrosis factor-alpha	null	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|amod|END_ENTITY	Bipyridyl_dihydrochloride inhibits tumor_necrosis_factor-alpha secretion by human keratinocytes on ultraviolet irradiation .
25621531	0	Bis-aryl_Urea	0,13	LIM_Kinase	50,60	Bis-aryl Urea	LIM Kinase	null	3984	Chemical	Gene	Derivatives|amod|START_ENTITY Derivatives|nmod|END_ENTITY	Bis-aryl_Urea Derivatives as Potent and Selective LIM_Kinase -LRB- Limk -RRB- Inhibitors .
24482362	0	Bis-arylidene_oxindoles	0,23	estrogen_receptor	68,85	Bis-arylidene oxindoles	estrogen receptor	null	2099	Chemical	Gene	START_ENTITY|acl|acting acting|nmod|END_ENTITY	Bis-arylidene_oxindoles as anti-breast-cancer agents acting via the estrogen_receptor .
18954040	0	Bis-pyranobenzoquinones	0,23	P-glycoprotein	109,123	Bis-pyranobenzoquinones	P-glycoprotein	null	5243	Chemical	Gene	mediated|nsubj|START_ENTITY mediated|nmod|END_ENTITY	Bis-pyranobenzoquinones as a new family of reversal agents of the multidrug resistance phenotype mediated by P-glycoprotein in mammalian cells and the protozoan parasite Leishmania .
19467701	0	BisGMA	14,20	cyclooxygenase-2	24,40	BisGMA	cyclooxygenase-2	MESH:D017438	5743	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|amod|END_ENTITY	The effect of BisGMA on cyclooxygenase-2 expression , PGE2 production and cytotoxicity via reactive oxygen species - and MEK/ERK-dependent and - independent pathways .
15743199	0	Bisaryloxime_ethers	0,19	transthyretin	44,57	Bisaryloxime ethers	transthyretin	null	7276	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Bisaryloxime_ethers as potent inhibitors of transthyretin amyloid fibril formation .
24376609	0	Bisgma	0,6	cyclooxygenase-2	65,81	Bisgma	cyclooxygenase-2	MESH:D017438	19225(Tax:10090)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|macrophages macrophages|nmod|A2 A2|amod|END_ENTITY	Bisgma stimulates prostaglandin_E2 production in macrophages via cyclooxygenase-2 , cytosolic phospholipase A2 , and mitogen-activated protein kinases family .
25725483	0	Bisphenol-A	0,11	HOXC6	34,39	Bisphenol-A	HOXC6	MESH:C006780	252885(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Bisphenol-A induces expression of HOXC6 , an estrogen-regulated homeobox-containing gene associated with breast_cancer .
23707772	0	Bisphenol_A	0,11	Cyp11a1	41,48	Bisphenol A	Cyp11a1	MESH:C006780	13070(Tax:10090)	Chemical	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|END_ENTITY	Bisphenol_A down-regulates rate-limiting Cyp11a1 to acutely inhibit steroidogenesis in cultured mouse antral follicles .
20875696	0	Bisphenol_A	0,11	Erk1/2	42,48	Bisphenol A	Erk1/2	MESH:C006780	5595;5594	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|nmod|END_ENTITY	Bisphenol_A induces a rapid activation of Erk1/2 through GPR30 in human breast_cancer cells .
22552965	0	Bisphenol_A	0,11	GPER	78,82	Bisphenol A	GPER	MESH:C006780	2852	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Bisphenol_A induces gene expression changes and proliferative effects through GPER in breast_cancer cells and cancer-associated fibroblasts .
26914403	0	Bisphenol_A	0,11	GPER	40,44	Bisphenol A	GPER	MESH:C006780	2852	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|pathway pathway|amod|END_ENTITY	Bisphenol_A induces migration through a GPER , FAK , Src and ERK2-dependent pathway in MDA-MB-231 breast_cancer cells .
20875696	0	Bisphenol_A	0,11	GPR30	57,62	Bisphenol A	GPR30	MESH:C006780	2852	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Bisphenol_A induces a rapid activation of Erk1/2 through GPR30 in human breast_cancer cells .
26490843	0	Bisphenol_A	0,11	Gper	122,126	Bisphenol A	Gper	MESH:C006780	565271(Tax:7955)	Chemical	Gene	Actions|compound|START_ENTITY /|nsubj|Actions /|nmod|G_Protein-Coupled_Estrogen_Receptor_1 G_Protein-Coupled_Estrogen_Receptor_1|appos|END_ENTITY	Bisphenol_A and Related_Alkylphenols Exert Nongenomic Estrogenic Actions Through a G_Protein-Coupled_Estrogen_Receptor_1 -LRB- Gper -RRB- / Epidermal_Growth_Factor_Receptor -LRB- Egfr -RRB- Pathway to Inhibit Meiotic Maturation of Zebrafish Oocytes .
26914403	0	Bisphenol_A	0,11	Src	51,54	Bisphenol A	Src	MESH:C006780	6714	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|pathway pathway|amod|END_ENTITY	Bisphenol_A induces migration through a GPER , FAK , Src and ERK2-dependent pathway in MDA-MB-231 breast_cancer cells .
20383177	0	Bisphenol_A	0,11	TNF-alpha	32,41	Bisphenol A	TNF-alpha	MESH:C006780	7124	Chemical	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	Bisphenol_A in combination with TNF-alpha selectively induces Th2 cell-promoting dendritic cells in vitro with an estrogen-like activity .
25068083	0	Bisphenol_A	0,11	aP2	22,25	Bisphenol A	aP2	MESH:C006780	11770(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Bisphenol_A increases aP2 expression in 3T3L1 by enhancing the transcriptional activity of nuclear receptors at the promoter .
19079714	0	Bisphenol_A	0,11	adiponectin	55,66	Bisphenol A	adiponectin	MESH:C006780	9370	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|compound|END_ENTITY	Bisphenol_A at environmentally relevant doses inhibits adiponectin release from human adipose tissue explants and adipocytes .
25048886	0	Bisphenol_A	0,11	adiponectin	48,59	Bisphenol A	adiponectin	MESH:C006780	9370	Chemical	Gene	related|nsubjpass|START_ENTITY related|nmod|circulating circulating|dobj|levels levels|nmod|END_ENTITY	Bisphenol_A is related to circulating levels of adiponectin , leptin and ghrelin , but not to fat mass or fat distribution in humans .
23928317	0	Bisphenol_A	0,11	aryl_hydrocarbon_receptor	78,103	Bisphenol A	aryl hydrocarbon receptor	MESH:C006780	11622(Tax:10090)	Chemical	Gene	inhibits|compound|START_ENTITY cultured|nsubj|inhibits cultured|nmod|END_ENTITY	Bisphenol_A inhibits cultured mouse ovarian follicle growth partially via the aryl_hydrocarbon_receptor signaling pathway .
25933419	0	Bisphenol_A	20,31	c-Myc	93,98	Bisphenol A	c-Myc	MESH:C006780	4609	Chemical	Gene	Effects|nmod|START_ENTITY Effects|dep|Role Role|nmod|END_ENTITY	Effects of Low-Dose Bisphenol_A on DNA Damage and Proliferation of Breast Cells : The Role of c-Myc .
23915859	0	Bisphenol_A	0,11	cyclooxygenase-2	54,70	Bisphenol A	cyclooxygenase-2	MESH:C006780	5743	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Bisphenol_A at environmentally relevant doses induces cyclooxygenase-2 expression and promotes invasion of human mesenchymal stem cells derived from uterine_myoma tissue .
11771854	0	Bisphenol_A	0,11	estrogen_receptor	46,63	Bisphenol A	estrogen receptor	MESH:C006780	2099	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Bisphenol_A enhances cadmium toxicity through estrogen_receptor .
9783916	0	Bisphenol_A	0,11	estrogen_receptor_alpha	31,54	Bisphenol A	estrogen receptor alpha	MESH:C006780	2099	Chemical	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Bisphenol_A interacts with the estrogen_receptor_alpha in a distinct manner from estradiol .
22343039	0	Bisphenol_A	0,11	leptin	20,26	Bisphenol A	leptin	MESH:C006780	3952	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Bisphenol_A induces leptin receptor expression , creating more binding sites for leptin , and activates the JAK/Stat , MAPK/ERK and PI3K/Akt signalling pathways in human ovarian_cancer cell .
11879183	0	Bisphenol_A_diglycidyl_ether	0,28	peroxisome_proliferator-activated_receptor-gamma	80,128	Bisphenol A diglycidyl ether	peroxisome proliferator-activated receptor-gamma	MESH:C019273	5468	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|apoptosis apoptosis|nmod|cells cells|nmod|END_ENTITY	Bisphenol_A_diglycidyl_ether induces apoptosis in tumour cells independently of peroxisome_proliferator-activated_receptor-gamma , in caspase-dependent and - independent manners .
26867649	0	Bisphenol_S	25,36	K-Ras4B	46,53	Bisphenol S	K-Ras4B	MESH:C543008	3845	Chemical	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	The Bisphenol_A analogue Bisphenol_S binds to K-Ras4B - implications for ` BPA-free ' plastics .
11991651	0	Bisphenol_a_diglycidyl_ether	0,28	tumor_necrosis_factor-alpha	48,75	Bisphenol a diglycidyl ether	tumor necrosis factor-alpha	MESH:C019273	21926(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|production production|amod|END_ENTITY	Bisphenol_a_diglycidyl_ether -LRB- BADGE -RRB- suppresses tumor_necrosis_factor-alpha production as a PPARgamma agonist in the murine macrophage-like cell line , RAW 264.7 .
15775084	0	Bisphosphonate	1,15	GnRH	20,24	Bisphosphonate	GnRH	null	2796	Chemical	Gene	START_ENTITY|nmod|therapy therapy|compound|END_ENTITY	-LSB- Bisphosphonate for GnRH therapy -RSB- .
9504956	0	Bisphosphonate	0,14	parathyroid_hormone	25,44	Bisphosphonate	parathyroid hormone	null	24694(Tax:10116)	Chemical	Gene	maintains|nsubj|START_ENTITY maintains|dobj|END_ENTITY	Bisphosphonate maintains parathyroid_hormone -LRB- 1-34 -RRB- - induced cortical bone mass and mechanical strength in old rats .
27095621	0	Bisphosphonates	10,25	Rankl	43,48	Bisphosphonates	Rankl	MESH:D004164	8600	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of Bisphosphonates on the Levels of Rankl and Opg in Gingival Crevicular Fluid of Patients With Periodontal_Disease and Post-menopausal_Osteoporosis .
16892369	0	Bisubstrate	0,11	catechol_O-methyltransferase	26,54	Bisubstrate	catechol O-methyltransferase	null	1312	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Bisubstrate inhibitors of catechol_O-methyltransferase -LRB- COMT -RRB- : the crucial role of the ribose structural unit for inhibitor binding affinity .
11833835	0	Bivalirudin	0,11	thrombin	22,30	Bivalirudin	thrombin	MESH:C074619	2147	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Bivalirudin : a direct thrombin inhibitor .
12173785	0	Bivalirudin	0,11	thrombin	22,30	Bivalirudin	thrombin	MESH:C074619	2147	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Bivalirudin : a direct thrombin inhibitor for percutaneous transluminal coronary angioplasty .
19804047	0	Bivalirudin	0,11	thrombin	22,30	Bivalirudin	thrombin	MESH:C074619	2147	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Bivalirudin : a direct thrombin inhibitor used during percutaneous coronary intervention .
21364148	0	Bivalirudin	0,11	thrombin	35,43	Bivalirudin	thrombin	MESH:C074619	2147	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|activation activation|compound|END_ENTITY	Bivalirudin is a dual inhibitor of thrombin and collagen-dependent platelet activation in patients undergoing percutaneous coronary intervention .
27102960	0	Bl1002494	30,39	Syk	15,18	Bl1002494	Syk	null	20963(Tax:10090)	Chemical	Gene	Inhibitor|appos|START_ENTITY Inhibitor|compound|END_ENTITY	The Novel Oral Syk Inhibitor , Bl1002494 , Protects Mice From Arterial Thrombosis and Thromboinflammatory_Brain_Infarction .
15641783	0	Blebbistatin	0,12	myosin	16,22	Blebbistatin	myosin	MESH:C472645	79784	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Blebbistatin , a myosin II inhibitor , is photoinactivated by blue light .
15671182	0	Blebbistatin	0,12	myosin	42,48	Blebbistatin	myosin	MESH:C472645	79784	Chemical	Gene	II|amod|START_ENTITY II|compound|END_ENTITY	Blebbistatin and blebbistatin-inactivated myosin II inhibit myosin II-independent processes in Dictyostelium .
15671182	0	Blebbistatin	0,12	myosin	60,66	Blebbistatin	myosin	MESH:C472645	79784	Chemical	Gene	II|amod|START_ENTITY inhibit|nsubj|II inhibit|dobj|processes processes|amod|END_ENTITY	Blebbistatin and blebbistatin-inactivated myosin II inhibit myosin II-independent processes in Dictyostelium .
18599626	0	Blebbistatin	0,12	myosin	45,51	Blebbistatin	myosin	MESH:C472645	79784	Chemical	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|order order|nmod|filaments filaments|compound|END_ENTITY	Blebbistatin stabilizes the helical order of myosin filaments by promoting the switch 2 closed state .
22507270	0	Blebbistatin	0,12	myosin	16,22	Blebbistatin	myosin	MESH:C472645	79784	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Blebbistatin , a myosin inhibitor , is phototoxic to human cancer cells under exposure to blue light .
12408953	0	Bleomycin	0,9	E-selectin	18,28	Bleomycin	E-selectin	MESH:D001761	6401	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Bleomycin induces E-selectin expression in cultured umbilical vein endothelial cells by increasing its mRNA levels through activation of NF-kappaB/Rel .
15384255	0	Bleomycin	0,9	IL-8	18,22	Bleomycin	IL-8	MESH:D001761	3576	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Bleomycin induces IL-8 and ICAM-1 expression in microvascular pulmonary endothelial cells .
19442053	0	Bleomycin	0,9	caveolin-1	98,108	Bleomycin	caveolin-1	MESH:D001761	857	Chemical	Gene	START_ENTITY|dep|effects effects|nmod|END_ENTITY	Bleomycin and its role in inducing apoptosis and senescence in lung cells - modulating effects of caveolin-1 .
2432621	0	Bleomycin	0,9	tyrosinase	23,33	Bleomycin	tyrosinase	MESH:D001761	7299	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|amod|END_ENTITY	Bleomycin enhances the tyrosinase activity of human malignant_melanoma cells in culture .
2170155	0	Bombesin	0,8	c-fos	24,29	Bombesin	c-fos	MESH:D001839	14281(Tax:10090)	Chemical	Gene	stimulation|compound|START_ENTITY stimulation|nmod|expression expression|amod|END_ENTITY	Bombesin stimulation of c-fos expression and mitogenesis in Swiss_3T3 cells : the role of prostaglandin_E2-mediated cyclic_AMP accumulation .
3108267	0	Bombesin	0,8	c-fos	22,27	Bombesin	c-fos	MESH:D001839	14281(Tax:10090)	Chemical	Gene	induction|compound|START_ENTITY induction|nmod|proto-oncogenes proto-oncogenes|amod|END_ENTITY	Bombesin induction of c-fos and c-myc proto-oncogenes in Swiss_3T3 cells : significance for the mitogenic response .
3494622	0	Bombesin	0,8	c-fos	17,22	Bombesin	c-fos	MESH:D001839	14281(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Bombesin induces c-fos and c-myc expression in quiescent Swiss_3T3 cells .
3758207	0	Bombesin	0,8	c-fos	24,29	Bombesin	c-fos	MESH:D001839	14281(Tax:10090)	Chemical	Gene	stimulation|compound|START_ENTITY stimulation|nmod|END_ENTITY	Bombesin stimulation of c-fos and c-myc gene expression in cultures of Swiss_3T3 cells .
9558040	0	Bombesin	0,8	gastrin	53,60	Bombesin	gastrin	MESH:D001839	25320(Tax:10116)	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|nmod|rat rat|dep|role role|nmod|END_ENTITY	Bombesin prevents gastric_injury in the rat : role of gastrin .
385299	0	Bombesin	0,8	insulin	35,42	Bombesin	insulin	MESH:D001839	483665(Tax:9615)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|nmod|END_ENTITY	Bombesin stimulates the release of insulin and glucagon , but not pancreatic somatostatin , from the isolated perfused dog pancreas .
6361710	0	Bombesin	0,8	insulin	20,27	Bombesin	insulin	MESH:D001839	100997985	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|compound|END_ENTITY	Bombesin stimulates insulin secretion and reduces food intake in the baboon .
8795079	0	Bombesin	0,8	phospholipase_C_beta_1	23,45	Bombesin	phospholipase C beta 1	MESH:D001839	24654(Tax:10116)	Chemical	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Bombesin activation of phospholipase_C_beta_1 in rat acinar pancreatic cells involves the pertussis toxin-sensitive G alpha i3 protein .
2829290	0	Bombesin	0,8	prolactin	20,29	Bombesin	prolactin	MESH:D001839	24683(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|compound|END_ENTITY	Bombesin stimulates prolactin secretion from cultured rat pituitary_tumour cells -LRB- GH4C1 -RRB- via activation of phospholipase C. Bombesin -LRB- BBS -RRB- stimulated prolactin -LRB- PRL -RRB- secretion from monolayer cultures of rat pituitary_tumour cells -LRB- GH4C1 -RRB- in a dose-dependent manner with half maximal and maximal effect at 2 nM and 100 nM , respectively .
2829290	0	Bombesin	124,132	prolactin	20,29	Bombesin	prolactin	MESH:D001839	24683(Tax:10116)	Chemical	Gene	activation|nmod|START_ENTITY cells|nmod|activation stimulates|nmod|cells stimulates|dobj|secretion secretion|compound|END_ENTITY	Bombesin stimulates prolactin secretion from cultured rat pituitary_tumour cells -LRB- GH4C1 -RRB- via activation of phospholipase C. Bombesin -LRB- BBS -RRB- stimulated prolactin -LRB- PRL -RRB- secretion from monolayer cultures of rat pituitary_tumour cells -LRB- GH4C1 -RRB- in a dose-dependent manner with half maximal and maximal effect at 2 nM and 100 nM , respectively .
6799271	0	Bombesin	0,8	prolactin	20,29	Bombesin	prolactin	MESH:D001839	24683(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|compound|END_ENTITY	Bombesin stimulates prolactin and growth hormone release by pituitary cells in culture .
17220209	0	Borate	0,6	SLC4A11	19,26	Borate	SLC4A11	CHEBI:22908	83959	Chemical	Gene	mutations|amod|START_ENTITY mutations|compound|END_ENTITY	Borate transporter SLC4A11 mutations cause both Harboyan_syndrome and non-syndromic_corneal_endothelial_dystrophy .
22576912	0	Boric_acid	0,10	SLC4A2	74,80	Boric acid	SLC4A2	MESH:C032688	6522	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|nmod|END_ENTITY	Boric_acid increases the expression levels of human anion exchanger genes SLC4A2 and SLC4A3 .
26593909	0	Borneol	0,7	P-Glycoprotein	18,32	Borneol	P-Glycoprotein	MESH:C022871	287115(Tax:10116)	Chemical	Gene	Function|compound|START_ENTITY Function|compound|END_ENTITY	Borneol Depresses P-Glycoprotein Function by a NF-kB Signaling Mediated Mechanism in a Blood Brain Barrier in Vitro Model .
19467880	0	Boron	0,5	EGFR	33,37	Boron	EGFR	MESH:D001895	24329(Tax:10116)	Chemical	Gene	therapy|compound|START_ENTITY therapy|nmod|END_ENTITY	Boron neutron capture therapy of EGFR or EGFRvIII positive gliomas using either boronated monoclonal antibodies or epidermal_growth_factor as molecular targeting agents .
25670713	0	Boron	137,142	Tip	163,166	Boron	Tip	MESH:D001895	832530(Tax:3702)	Chemical	Gene	Accumulation|compound|START_ENTITY Accumulation|nmod|END_ENTITY	Mathematical Modeling and Experimental Validation of the Spatial Distribution of Boron in the Root of Arabidopsis_thaliana Identify High Boron Accumulation in the Tip and Predict a Distinct Root Tip Uptake Function .
25233453	0	Boronic_Acids	0,13	CXCR3	93,98	Boronic Acids	CXCR3	MESH:D001897	2833	Chemical	Gene	START_ENTITY|nmod|Modulation Modulation|nmod|END_ENTITY	Boronic_Acids as Probes for Investigation of Allosteric Modulation of the Chemokine Receptor CXCR3 .
25580517	0	Boronophenylalanine	0,19	ATB0	97,101	Boronophenylalanine	ATB0	null	6510	Chemical	Gene	transported|nsubjpass|START_ENTITY transported|nmod|END_ENTITY	Boronophenylalanine , a boron delivery agent for boron neutron capture therapy , is transported by ATB0 , + , LAT1 and LAT2 .
21678129	0	Borrelidin	0,10	threonyl-tRNA_synthetase	71,95	Borrelidin	threonyl-tRNA synthetase	MESH:C005066	6897	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Borrelidin , a small molecule nitrile-containing macrolide inhibitor of threonyl-tRNA_synthetase , is a potent inducer of apoptosis in acute_lymphoblastic_leukemia .
24842158	0	Bortezomib	0,10	AMP-activated_protein_kinase	48,76	Bortezomib	AMP-activated protein kinase	MESH:C400082	5563	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|amod|END_ENTITY	Bortezomib induces protective autophagy through AMP-activated_protein_kinase activation in cultured pancreatic and colorectal_cancer cells .
22054286	0	Bortezomib	0,10	Bcl-2	52,57	Bortezomib	Bcl-2	MESH:C400082	596	Chemical	Gene	mitigates|nsubj|START_ENTITY mitigates|ccomp|conferred conferred|nmod|overexpression overexpression|compound|END_ENTITY	Bortezomib mitigates adverse prognosis conferred by Bcl-2 overexpression in patients with relapsed/refractory multiple_myeloma .
25275021	0	Bortezomib	51,61	Bcl-2	23,28	Bortezomib	Bcl-2	MESH:C400082	596	Chemical	Gene	Inhibitor|nmod|START_ENTITY Inhibitor|compound|END_ENTITY	Promise of Combining a Bcl-2 Family Inhibitor with Bortezomib or SAHA for Adult_T-cell_Leukemia / Lymphoma .
21447826	0	Bortezomib	0,10	C/EBPb	24,30	Bortezomib	C/EBPb	MESH:C400082	1051	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Bortezomib induction of C/EBPb mediates Epstein-Barr_virus lytic activation in Burkitt_lymphoma .
20200358	0	Bortezomib	0,10	CD20	29,33	Bortezomib	CD20	MESH:C400082	54474	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Bortezomib modulates surface CD20 in B-cell malignancies and affects rituximab-mediated complement-dependent cytotoxicity .
26528182	0	Bortezomib	0,10	CHIT1	21,26	Bortezomib	CHIT1	MESH:C400082	1118	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Bortezomib modulates CHIT1 and YKL40 in monocyte-derived osteoclast and in myeloma cells .
21209804	0	Bortezomib	71,81	CHOP	87,91	Bortezomib	CHOP	MESH:C400082	1649	Chemical	Gene	Therapy|compound|START_ENTITY Therapy|compound|END_ENTITY	Rapid Remission in Peripheral_T-Cell_Lymphoma of the Nasal Type by the Bortezomib plus CHOP Therapy .
21393428	0	Bortezomib	0,10	CIP2A	110,115	Bortezomib	CIP2A	MESH:C400082	57650	Chemical	Gene	sensitizes|nsubj|START_ENTITY sensitizes|nmod|inhibition inhibition|nmod|END_ENTITY	Bortezomib sensitizes HCC cells to CS-1008 , an antihuman death_receptor_5 antibody , through the inhibition of CIP2A .
22085493	0	Bortezomib	0,10	CIP2A	78,83	Bortezomib	CIP2A	MESH:C400082	57650	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|advcl|inhibiting inhibiting|dobj|END_ENTITY	Bortezomib enhances radiation-induced apoptosis in solid tumors by inhibiting CIP2A .
24335617	0	Bortezomib	0,10	CIP2A	70,75	Bortezomib	CIP2A	MESH:C400082	57650	Chemical	Gene	congeners|nsubj|START_ENTITY congeners|xcomp|induce induce|dobj|apoptosis_of_hepatocellular_carcinoma apoptosis_of_hepatocellular_carcinoma|nmod|inhibition inhibition|compound|END_ENTITY	Bortezomib congeners induce apoptosis_of_hepatocellular_carcinoma via CIP2A inhibition .
21224428	0	Bortezomib	0,10	IkBa	44,48	Bortezomib	IkBa	MESH:C400082	4792	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|translocation translocation|nmod|END_ENTITY	Bortezomib induces nuclear translocation of IkBa resulting in gene-specific suppression of NF-kB -- dependent transcription and induction of apoptosis in CTCL .
23334228	0	Bortezomib	0,10	MGMT	25,29	Bortezomib	MGMT	MESH:C400082	4255	Chemical	Gene	downregulates|compound|START_ENTITY END_ENTITY|nsubj|downregulates	Bortezomib downregulates MGMT expression in T98G glioblastoma cells .
25172660	0	Bortezomib	0,10	MMP-13	38,44	Bortezomib	MMP-13	MESH:C400082	4322	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|dobj|expression expression|nmod|END_ENTITY	Bortezomib prevents the expression of MMP-13 and the degradation of collagen type 2 in human chondrocytes .
19054826	2	Bortezomib	212,222	NF-kappaB	232,241	Bortezomib	NF-kappaB	MESH:C400082	18033(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	Bortezomib inhibits NF-kappaB activation by blocking the degradation of the NF-kappaB inhibitor , I-kappaB .
21633906	0	Bortezomib	0,10	NOXA	22,26	Bortezomib	NOXA	MESH:C400082	5366	Chemical	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	Bortezomib stabilizes NOXA and triggers ROS-associated apoptosis in medulloblastoma .
25681335	0	Bortezomib	0,10	TGF-b1	34,40	Bortezomib	TGF-b1	MESH:C400082	7040	Chemical	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	Bortezomib Inhibits Expression of TGF-b1 , IL-10 , and CXCR4 , Resulting in Decreased Survival and Migration of Cutaneous_T_Cell_Lymphoma Cells .
17875785	0	Bortezomib	0,10	TRAIL	146,151	Bortezomib	TRAIL	MESH:C400082	8743	Chemical	Gene	sensitizes|nsubj|START_ENTITY sensitizes|nmod|apoptosis apoptosis|acl|induced induced|nmod|factor factor|acl|related related|dobj|receptors receptors|appos|END_ENTITY	Bortezomib sensitizes non-Hodgkin 's _ lymphoma cells to apoptosis induced by antibodies to tumor necrosis factor related apoptosis-inducing ligand -LRB- TRAIL -RRB- receptors TRAIL-R1 and TRAIL-R2 .
18160669	0	Bortezomib	0,10	TRAIL	77,82	Bortezomib	TRAIL	MESH:C400082	8743	Chemical	Gene	blocks|nsubj|START_ENTITY blocks|nmod|treatment treatment|nmod|END_ENTITY	Bortezomib blocks Bax degradation in malignant B cells during treatment with TRAIL .
18223318	0	Bortezomib	21,31	TRAIL	152,157	Bortezomib	TRAIL	MESH:C400082	8743	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|lines lines|acl|derived derived|nmod|END_ENTITY	Proteasome inhibitor Bortezomib induces cell cycle arrest and apoptosis in cell lines derived from Ewing 's _ sarcoma family of tumors and synergizes with TRAIL .
19768634	3	Bortezomib	537,547	TRAIL	568,573	Bortezomib	TRAIL	MESH:C400082	8743	Chemical	Gene	employed|nmod|START_ENTITY employed|nmod|END_ENTITY	Using primary_esthesioneuroblastoma cells we analyzed the anti-tumor potential and the mechanism employed by Bortezomib in combination with TRAIL for the treatment of this rare but aggressive tumor .
20442297	0	Bortezomib	0,10	TRAIL	53,58	Bortezomib	TRAIL	MESH:C400082	8743	Chemical	Gene	sensitizes|nsubj|START_ENTITY sensitizes|xcomp|END_ENTITY	Bortezomib sensitizes human renal_cell_carcinomas to TRAIL apoptosis through increased activation of caspase-8 in the death-inducing signaling complex .
21220502	0	Bortezomib	0,10	TRAIL	54,59	Bortezomib	TRAIL	MESH:C400082	8743	Chemical	Gene	sensitizes|nsubj|START_ENTITY sensitizes|nmod|END_ENTITY	Bortezomib sensitizes malignant human glioma cells to TRAIL , mediated by inhibition of the NF - -LCB- kappa -RCB- B signaling pathway .
21525171	0	Bortezomib	0,10	TRAIL	71,76	Bortezomib	TRAIL	MESH:C400082	8743	Chemical	Gene	primes|nsubj|START_ENTITY primes|nmod|END_ENTITY	Bortezomib primes glioblastoma , including glioblastoma stem cells , for TRAIL by increasing tBid stability and mitochondrial apoptosis .
24212664	0	Bortezomib	25,35	TRAIL	90,95	Bortezomib	TRAIL	MESH:C400082	8743	Chemical	Gene	Sensitizes|compound|START_ENTITY AML|nsubj|Sensitizes AML|nmod|Apoptosis Apoptosis|compound|END_ENTITY	The Proteasome Inhibitor Bortezomib Sensitizes AML with Myelomonocytic Differentiation to TRAIL Mediated Apoptosis .
25341043	0	Bortezomib	0,10	TRAIL	81,86	Bortezomib	TRAIL	MESH:C400082	8743	Chemical	Gene	sensitises|nsubj|START_ENTITY sensitises|xcomp|END_ENTITY	Bortezomib sensitises TRAIL-resistant HPV-positive head_and_neck_cancer cells to TRAIL through a caspase-dependent , E6-independent mechanism .
25051198	0	Bortezomib	0,10	WWP1	85,89	Bortezomib	WWP1	MESH:C400082	11059	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|nmod|END_ENTITY	Bortezomib prevents oncogenesis and bone metastasis of prostate_cancer by inhibiting WWP1 , Smurf1 and Smurf2 .
20006625	0	Bortezomib	0,10	focal_adhesion_kinase	22,43	Bortezomib	focal adhesion kinase	MESH:C400082	5747	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Bortezomib suppresses focal_adhesion_kinase expression via interrupting nuclear factor-kappa B. AIMS : Bortezomib is a potent proteasome inhibitor currently used to treat various_malignancies with promising results .
20006625	0	Bortezomib	102,112	focal_adhesion_kinase	22,43	Bortezomib	focal adhesion kinase	MESH:C400082	5747	Chemical	Gene	inhibitor|nsubj|START_ENTITY suppresses|parataxis|inhibitor suppresses|dobj|expression expression|amod|END_ENTITY	Bortezomib suppresses focal_adhesion_kinase expression via interrupting nuclear factor-kappa B. AIMS : Bortezomib is a potent proteasome inhibitor currently used to treat various_malignancies with promising results .
22617388	0	Bortezomib	0,10	heme_oxygenase-1	19,35	Bortezomib	heme oxygenase-1	MESH:C400082	3162	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Bortezomib induces heme_oxygenase-1 expression in multiple myeloma .
23647062	0	Bortezomib	0,10	interferon_regulatory_factor_4	46,76	Bortezomib	interferon regulatory factor 4	MESH:C400082	3662	Chemical	Gene	down-modulates|nsubj|START_ENTITY down-modulates|dobj|END_ENTITY	Bortezomib down-modulates the survival factor interferon_regulatory_factor_4 in Hodgkin_lymphoma cell lines and decreases the protective activity of Hodgkin_lymphoma-associated fibroblasts .
23716467	0	Bortezomib	0,10	p21	93,96	Bortezomib	p21	MESH:C400082	644914	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Bortezomib induces apoptosis of endometrial_cancer cells through microRNA-17-5p by targeting p21 .
18451165	0	Bortezomib	0,10	p27Kip1	29,36	Bortezomib	p27Kip1	MESH:C400082	12576(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Bortezomib -LRB- Velcade -RRB- induces p27Kip1 expression through S-phase_kinase_protein_2 degradation in colorectal_cancer .
19261616	0	Bortezomib	0,10	tumor_necrosis_factor-related_apoptosis-inducing_ligand	21,76	Bortezomib	tumor necrosis factor-related apoptosis-inducing ligand	MESH:C400082	8743	Chemical	Gene	overcomes|nsubj|START_ENTITY overcomes|dobj|resistance resistance|amod|END_ENTITY	Bortezomib overcomes tumor_necrosis_factor-related_apoptosis-inducing_ligand resistance in hepatocellular_carcinoma cells in part through the inhibition of the phosphatidylinositol 3-kinase/Akt pathway .
7869843	0	Bosentan	0,8	endothelin-1	36,48	Bosentan	endothelin-1	MESH:C086232	24323(Tax:10116)	Chemical	Gene	antagonizes|nsubj|START_ENTITY antagonizes|dobj|effects effects|nmod|flow flow|amod|END_ENTITY	Bosentan antagonizes the effects of endothelin-1 on rat gastric blood flow and mucosal integrity .
9085162	0	Bosentan	0,8	endothelin-1	175,187	Bosentan	endothelin-1	MESH:C086232	24323(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|parataxis|END_ENTITY	Bosentan , a novel synthetic mixed-type endothelin receptor antagonist , attenuates acute gastric_mucosal_lesions induced by indomethacin and HCl in the rat : role of endogenous endothelin-1 .
19951413	0	Boswellic_acid	0,14	acid_sphingomyelinase	38,59	Boswellic acid	acid sphingomyelinase	MESH:C054625	6609	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Boswellic_acid inhibits expression of acid_sphingomyelinase in intestinal cells .
9839674	0	Bothroalternin	0,14	thrombin	18,26	Bothroalternin	thrombin	MESH:C117903	100009146(Tax:9986)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Bothroalternin , a thrombin inhibitor from the venom of Bothrops alternatus .
16707920	0	Bothrojaracin	0,13	thrombin	60,68	Bothrojaracin	thrombin	MESH:C083739	29251(Tax:10116)	Chemical	Gene	START_ENTITY|appos|venom-derived venom-derived|dep|inhibitor inhibitor|compound|END_ENTITY	Bothrojaracin , a Bothrops jararaca snake venom-derived -LRB- pro -RRB- thrombin inhibitor , as an anti-thrombotic molecule .
8399228	0	Bothrojaracin	0,13	thrombin	113,121	Bothrojaracin	thrombin	MESH:C083739	2147	Chemical	Gene	START_ENTITY|dep|characterization characterization|nmod|inhibition inhibition|compound|END_ENTITY	Bothrojaracin , a new thrombin inhibitor isolated from Bothrops jararaca venom : characterization and mechanism of thrombin inhibition .
8399228	0	Bothrojaracin	0,13	thrombin	21,29	Bothrojaracin	thrombin	MESH:C083739	2147	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Bothrojaracin , a new thrombin inhibitor isolated from Bothrops jararaca venom : characterization and mechanism of thrombin inhibition .
8703912	0	Bothrojaracin	0,13	thrombin	42,50	Bothrojaracin	thrombin	MESH:C083739	2147	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Bothrojaracin : a potent two-site-directed thrombin inhibitor .
19555120	0	Botryllamides	0,13	ABCG2	45,50	Botryllamides	ABCG2	null	9429	Chemical	Gene	START_ENTITY|dep|inhibitors inhibitors|nmod|END_ENTITY	Botryllamides : natural product inhibitors of ABCG2 .
25966851	0	Botryoisocoumarin_A	0,19	COX-2	27,32	Botryoisocoumarin A	COX-2	null	4513	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Botryoisocoumarin_A , a new COX-2 inhibitor from the mangrove Kandelia candel endophytic fungus Botryosphaeria sp .
10330262	0	Bradykinin	0,10	ACE	62,65	Bradykinin	ACE	MESH:D001920	24310(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|dep|role role|nmod|END_ENTITY	Bradykinin metabolism in the postinfarcted rat heart : role of ACE and neutral_endopeptidase_24 .11 .
15126918	0	Bradykinin	0,10	ACE	133,136	Bradykinin	ACE	MESH:D001920	24310(Tax:10116)	Chemical	Gene	metalloproteinases|compound|START_ENTITY involved|nsubjpass|metalloproteinases involved|nmod|inhibition inhibition|nmod|END_ENTITY	Bradykinin and matrix metalloproteinases are involved the structural alterations of rat small resistance arteries with inhibition of ACE and NEP .
7776388	0	Bradykinin	0,10	ACE	31,34	Bradykinin	ACE	MESH:D001920	24310(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|nsubj|receptor	Bradykinin receptor and tissue ACE binding in myocardial_fibrosis : response to chronic angiotensin_II or aldosterone administration in rats .
14635788	0	Bradykinin	0,10	MMP-2	22,27	Bradykinin	MMP-2	MESH:D001920	100719361	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|compound|END_ENTITY	Bradykinin stimulates MMP-2 production in guinea_pig tracheal smooth muscle cells .
8317326	0	Bradykinin	0,10	TNF-alpha	22,31	Bradykinin	TNF-alpha	MESH:D001920	24835(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY release|nmod|END_ENTITY	Bradykinin release of TNF-alpha plays a key role in the development of inflammatory_hyperalgesia .
8943466	0	Bradykinin	0,10	c-fos	22,27	Bradykinin	c-fos	MESH:D001920	314322(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Bradykinin stimulates c-fos expression , AP-1-DNA binding activity and proliferation of rat glomerular mesangial cells .
21185878	0	Bradykinin	0,10	calcitonin_gene-related_peptide	43,74	Bradykinin	calcitonin gene-related peptide	MESH:D001920	24241(Tax:10116)	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|amod|END_ENTITY	Bradykinin and prostaglandin_E regulate calcitonin_gene-related_peptide expression in cultured rat sensory neurons .
15249543	0	Bradykinin	0,10	cyclooxygenase-2	21,37	Bradykinin	cyclooxygenase-2	MESH:D001920	29527(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	Bradykinin regulates cyclooxygenase-2 in rat renal thick ascending limb cells .
15339989	0	Bradykinin	0,10	plasminogen_activator_inhibitor-1	21,54	Bradykinin	plasminogen activator inhibitor-1	MESH:D001920	18787(Tax:10090)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|amod|END_ENTITY	Bradykinin decreases plasminogen_activator_inhibitor-1 expression and facilitates matrix degradation in the renal tubulointerstitium under angiotensin-converting enzyme blockade .
8098650	0	Bradykinin	0,10	tyrosine_hydroxylase	20,40	Bradykinin	tyrosine hydroxylase	MESH:D001920	25085(Tax:10116)	Chemical	Gene	elevates|nsubj|START_ENTITY elevates|dobj|levels levels|amod|END_ENTITY	Bradykinin elevates tyrosine_hydroxylase and dopamine_beta-hydroxylase mRNA levels in PC12 cells .
17575982	0	Brasiliensin	0,12	thrombin	33,41	Brasiliensin	thrombin	null	2147	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Brasiliensin : A novel intestinal thrombin inhibitor from Triatoma brasiliensis -LRB- Hemiptera : Reduviidae -RRB- with an important role in blood intake .
14605219	0	Brassinolide	0,12	IAA5	21,25	Brassinolide	IAA5	MESH:C023623	838128(Tax:3702)	Chemical	Gene	induces|advmod|START_ENTITY induces|nsubj|END_ENTITY	Brassinolide induces IAA5 , IAA19 , and DR5 , a synthetic auxin response element in Arabidopsis , implying a cross talk point of brassinosteroid and auxin signaling .
23382196	0	Brefeldin_A	99,110	Set1	23,27	Brefeldin A	Set1	MESH:D020126	9739	Chemical	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	H3K4 methyltransferase Set1 is involved in maintenance of ergosterol homeostasis and resistance to Brefeldin_A .
24843827	0	Brefeldin_A	17,28	insulin_receptor	60,76	Brefeldin A	insulin receptor	MESH:D020126	3643	Chemical	Gene	effects|nmod|START_ENTITY effects|acl|signaling signaling|nmod|END_ENTITY	Novel effects of Brefeldin_A -LRB- BFA -RRB- in signaling through the insulin_receptor -LRB- IR -RRB- pathway and regulating FoxO1-mediated transcription .
7838144	0	Brefeldin_A	0,11	transferrin_receptor	31,51	Brefeldin A	transferrin receptor	MESH:D020126	7037	Chemical	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|END_ENTITY	Brefeldin_A down-regulates the transferrin_receptor in K562 cells .
12148291	0	Brevibacterium_ammoniagenes	47,74	MA-3	106,110	Brevibacterium ammoniagenes	MA-3	null	29944	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Study on the kinetics of immobilized cells of Brevibacterium_ammoniagenes MA-2_and_Brevibacterium flavum MA-3 -RSB- .
26261843	0	Brexpiprazole	0,13	dopamine_D2_receptor	21,41	Brexpiprazole	dopamine D2 receptor	null	1813	Chemical	Gene	START_ENTITY|dep|agonist agonist|amod|END_ENTITY	Brexpiprazole : a new dopamine_D2_receptor partial agonist for the treatment of schizophrenia and major_depressive_disorder .
24851118	0	Brilliant_Blue_G	11,27	Tumor_Necrosis_Factor-a	37,60	Brilliant Blue G	Tumor Necrosis Factor-a	MESH:C004692	21926(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|Levels Levels|compound|END_ENTITY	Effects of Brilliant_Blue_G on Serum Tumor_Necrosis_Factor-a Levels and Depression-like Behavior in Mice after Lipopolysaccharide Administration .
1852792	0	Brofaromine	0,11	MAO-A	55,60	Brofaromine	MAO-A	MESH:C038213	4128	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Brofaromine -- a selective , reversible , and short-acting MAO-A inhibitor : review of the pharmacological and clinical findings .
2685854	0	Brofaromine	1,12	MAO-A	55,60	Brofaromine	MAO-A	MESH:C038213	4128	Chemical	Gene	START_ENTITY|dep|-RSB- -RSB-|amod|END_ENTITY	-LSB- Brofaromine -- a selective , reversible and short-acting MAO-A inhibitor -RSB- .
19339108	0	Bromelain	0,9	COX-2	19,24	Bromelain	COX-2	null	19225(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Bromelain inhibits COX-2 expression by blocking the activation of MAPK regulated NF-kappa_B against skin_tumor-initiation triggering mitochondrial death pathway .
6276051	0	Bromocriptine	0,13	ACTH	25,29	Bromocriptine	ACTH	MESH:D001971	5443	Chemical	Gene	suppresses|amod|START_ENTITY END_ENTITY|nsubj|suppresses	Bromocriptine suppresses ACTH secretion from human pituitary_tumour cells in culture by a dopaminergic mechanism .
3080469	0	Bromocriptine	0,13	GH	45,47	Bromocriptine	GH	MESH:D001971	2688	Chemical	Gene	alter|nsubj|START_ENTITY alter|dobj|responsiveness responsiveness|appos|END_ENTITY	Bromocriptine does not alter growth_hormone -LRB- GH -RRB- responsiveness to GH-releasing hormone in acromegaly .
4039234	0	Bromocriptine	0,13	GH	55,57	Bromocriptine	GH	MESH:D001971	2688	Chemical	Gene	therapy|amod|START_ENTITY therapy|dep|effects effects|nmod|levels levels|compound|END_ENTITY	Bromocriptine therapy in acromegaly : effects on plasma GH levels , somatomedin-C levels and clinical activity .
24392395	0	Bromocriptine	70,83	Prolactin	113,122	Bromocriptine	Prolactin	MESH:D001971	5617	Chemical	Gene	START_ENTITY|nmod|Patients Patients|nmod|END_ENTITY	Induction of Ovulation with Clomiphene_Citrate Versus Clomiphene with Bromocriptine in PCOS Patients with Normal Prolactin : A Comparative Study .
26921571	0	Bromocriptine	65,78	Somatostatin	51,63	Bromocriptine	Somatostatin	MESH:D001971	6750	Chemical	Gene	sulfate|appos|START_ENTITY sulfate|compound|END_ENTITY	Congenital_fibrosarcoma in complete remission with Somatostatin , Bromocriptine , Retinoids , Vitamin_D3 , Vitamin_E , Vitamin_C , Melatonin , Calcium , Chondroitin sulfate associated with low doses of Cyclophosphamide in a 14-year Follow up .
11680511	0	Bromocriptine	0,13	c-myc	36,41	Bromocriptine	c-myc	MESH:D001971	4609	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Bromocriptine and the expression of c-myc and c-fos in human prolactinomas .
113143	0	Bromocriptine	0,13	growth_hormone	132,146	Bromocriptine	growth hormone	MESH:D001971	2688	Chemical	Gene	suppression|amod|START_ENTITY induced|nsubj|suppression induced|dobj|release release|amod|END_ENTITY	Bromocriptine suppression of TRH-stimulated prolactin and thyrotrophin release and accompanying inhibition of bromocriptine induced growth_hormone release by TRH in normal man .
15160292	0	Bromocriptine	0,13	growth_hormone	49,63	Bromocriptine	growth hormone	MESH:D001971	2688	Chemical	Gene	treatment|amod|START_ENTITY restores|nsubj|treatment restores|dobj|secretion secretion|amod|END_ENTITY	Bromocriptine treatment of prolactinoma restores growth_hormone secretion and causes catch-up growth in a prepubertal child .
1574954	0	Bromocriptine	0,13	growth_hormone	63,77	Bromocriptine	growth hormone	MESH:D001971	2688	Chemical	Gene	treatment|amod|START_ENTITY treatment|dep|effect effect|nmod|secretion secretion|compound|END_ENTITY	Bromocriptine treatment over 12 years in acromegaly : effect on growth_hormone and prolactin secretion .
25253414	0	Bromocriptine	0,13	growth_hormone	45,59	Bromocriptine	growth hormone	MESH:D001971	2688	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|secretion secretion|amod|END_ENTITY	Bromocriptine , a dopamine agonist , increases growth_hormone secretion in a patient with acromegaly .
3080469	0	Bromocriptine	0,13	growth_hormone	29,43	Bromocriptine	growth hormone	MESH:D001971	2688	Chemical	Gene	alter|nsubj|START_ENTITY alter|dobj|responsiveness responsiveness|amod|END_ENTITY	Bromocriptine does not alter growth_hormone -LRB- GH -RRB- responsiveness to GH-releasing hormone in acromegaly .
336245	0	Bromocriptine	0,13	growth_hormone	36,50	Bromocriptine	growth hormone	MESH:D001971	2688	Chemical	Gene	suppression|amod|START_ENTITY END_ENTITY|nsubj|suppression	Bromocriptine suppression of plasma growth_hormone in acromegaly .
347862	0	Bromocriptine	0,13	growth_hormone	62,76	Bromocriptine	growth hormone	MESH:D001971	2688	Chemical	Gene	therapy|amod|START_ENTITY therapy|dep|effects effects|nmod|END_ENTITY	Bromocriptine therapy in patients with acromegaly : effects on growth_hormone , somatomedin_A and prolactin .
3718102	0	Bromocriptine	0,13	growth_hormone	22,36	Bromocriptine	growth hormone	MESH:D001971	2688	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	Bromocriptine reduces growth_hormone in acromegaly .
6993548	0	Bromocriptine	0,13	insulin	30,37	Bromocriptine	insulin	MESH:D001971	3630	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Bromocriptine acute effect on insulin , glucagon and growth_hormone levels in acromegalic patients .
2583042	0	Bromocriptine	0,13	ornithine_decarboxylase	36,59	Bromocriptine	ornithine decarboxylase	MESH:D001971	24609(Tax:10116)	Chemical	Gene	microcapsules|amod|START_ENTITY inhibit|nsubj|microcapsules inhibit|dobj|activity activity|amod|END_ENTITY	Bromocriptine microcapsules inhibit ornithine_decarboxylase activity induced by Freund 's complete adjuvant in lymphoid tissues of male rats .
11243738	0	Bromocriptine	0,13	prolactin	42,51	Bromocriptine	prolactin	MESH:D001971	100413643	Chemical	Gene	administration|amod|START_ENTITY lowers|nsubj|administration lowers|dobj|END_ENTITY	Bromocriptine administration lowers serum prolactin and disrupts parental responsiveness in common_marmosets -LRB- Callithrix j. jacchus -RRB- .
16051446	0	Bromocriptine	0,13	prolactin	71,80	Bromocriptine	prolactin	MESH:D001971	5617	Chemical	Gene	treatment|amod|START_ENTITY treatment|dep|association association|nmod|levels levels|compound|END_ENTITY	Bromocriptine treatment for cocaine_addiction : association with plasma prolactin levels .
3751462	0	Bromocriptine	0,13	prolactin	27,36	Bromocriptine	prolactin	MESH:D001971	5617	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|macroadenomas macroadenomas|amod|END_ENTITY	Bromocriptine treatment of prolactin secreting macroadenomas : a radiological , ophthalmological_and_endocrinological_study .
6143030	0	Bromocriptine	0,13	prolactin	68,77	Bromocriptine	prolactin	MESH:D001971	5617	Chemical	Gene	eyedrops|nsubj|START_ENTITY eyedrops|advcl|affecting affecting|dobj|levels levels|compound|END_ENTITY	Bromocriptine eyedrops lower intraocular pressure without affecting prolactin levels .
627685	0	Bromocriptine	0,13	prolactin	31,40	Bromocriptine	prolactin	MESH:D001971	5617	Chemical	Gene	START_ENTITY|dep|effect effect|nmod|END_ENTITY	Bromocriptine : effect on serum prolactin and growth_hormone in psychogeriatric hospital patients .
6432759	0	Bromocriptine	0,13	prolactin	66,75	Bromocriptine	prolactin	MESH:D001971	5617	Chemical	Gene	START_ENTITY|nmod|surgery surgery|nmod|adenomas adenomas|amod|END_ENTITY	Bromocriptine in the management of infertile men after surgery of prolactin secreting adenomas .
7435124	0	Bromocriptine	0,13	prolactin	78,87	Bromocriptine	prolactin	MESH:D001971	5617	Chemical	Gene	treatment|amod|START_ENTITY treatment|dep|effect effect|nmod|levels levels|nmod|END_ENTITY	Bromocriptine treatment during early human pregnancy : effect on the levels of prolactin , sex steroids and placental_lactogen .
9181047	0	Bromocriptine	0,13	prolactin	127,136	Bromocriptine	prolactin	MESH:D001971	19109(Tax:10090)	Chemical	Gene	has|nsubj|START_ENTITY has|dobj|effect effect|nmod|lymphocytes lymphocytes|appos|effect effect|acl|mediated mediated|nmod|suppression suppression|nmod|secretion secretion|compound|END_ENTITY	Bromocriptine has little direct effect on murine lymphocytes , the immunomodulatory effect being mediated by the suppression of prolactin secretion .
11669288	0	Bromodeoxyuridine	0,17	keratin_19	28,38	Bromodeoxyuridine	keratin 19	MESH:D001973	3880	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Bromodeoxyuridine increases keratin_19 protein expression at a posttranscriptional level in two human lung_tumor cell lines .
2176354	0	Bromodeoxyuridine	0,17	tyrosinase	57,67	Bromodeoxyuridine	tyrosinase	MESH:D001973	101840761	Chemical	Gene	regulation|amod|START_ENTITY END_ENTITY|nsubj|regulation	Bromodeoxyuridine - and cyclic_AMP-mediated regulation of tyrosinase in Syrian_hamster melanoma cells .
4016175	0	Bromoergocryptine	0,17	prolactin	34,43	Bromoergocryptine	prolactin	null	101843376	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|END_ENTITY	Bromoergocryptine decreases serum prolactin and delays sexual maturation in male golden_hamsters .
8170942	0	Bromophenacyl_bromide	0,21	l-plastin	60,69	Bromophenacyl bromide	l-plastin	MESH:C006821	3936	Chemical	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	Bromophenacyl_bromide binding to the actin-bundling protein l-plastin inhibits inositol_trisphosphate-independent increase in Ca2 + in human neutrophils .
22444684	0	Bromophenols	0,12	protein_tyrosine_phosphatase_1B	30,61	Bromophenols	protein tyrosine phosphatase 1B	null	5770	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Bromophenols as inhibitors of protein_tyrosine_phosphatase_1B with antidiabetic properties .
26749833	0	Bromotyrosine_Alkaloids	0,23	Acetylcholinesterase	29,49	Bromotyrosine Alkaloids	Acetylcholinesterase	null	43	Chemical	Gene	START_ENTITY|nmod|Activity Activity|compound|END_ENTITY	Bromotyrosine_Alkaloids with Acetylcholinesterase Inhibitory Activity from the Thai Sponge Acanthodendrilla sp .
16630572	0	Bromovinyl-deoxyuridine	0,23	thymidine_kinase	65,81	Bromovinyl-deoxyuridine	thymidine kinase	null	57813(Tax:10090)	Chemical	Gene	START_ENTITY|dep|substrate substrate|nmod|END_ENTITY	Bromovinyl-deoxyuridine : A selective substrate for mitochondrial thymidine_kinase in cell extracts .
23769740	0	Broussoflavonol_B	25,42	estrogen_receptor	57,74	Broussoflavonol B	estrogen receptor	null	2099	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	A novel anticancer agent Broussoflavonol_B downregulates estrogen_receptor -LRB- ER -RRB- - a36 expression and inhibits growth of ER-negative breast_cancer MDA-MB-231 cells .
2572036	0	Broxaterol	0,10	beta_2-adrenoceptor	18,37	Broxaterol	beta 2-adrenoceptor	MESH:C045916	154	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Broxaterol , a new beta_2-adrenoceptor agonist compared to salbutamol in asthmatics , oral and inhalation treatment .
19286308	0	Bruceine_D	0,10	p38-mitogen_activated_protein_kinase	101,137	Bruceine D	p38-mitogen activated protein kinase	MESH:C030412	1432	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Bruceine_D induces apoptosis in pancreatic_adenocarcinoma cell line PANC-1 through the activation of p38-mitogen_activated_protein_kinase .
8850324	0	Brucine	0,7	CYP2B3	31,37	Brucine	CYP2B3	MESH:C083806	286953(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inducer inducer|nmod|END_ENTITY	Brucine as a potent inducer of CYP2B3 , the third member of the CYP2B subfamily P450 in rats .
23175437	0	Brucine	0,7	c-Jun	83,88	Brucine	c-Jun	MESH:C083806	3725	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Brucine induces the apoptosis of U266 multiple_myeloma cells by phosphorylation of c-Jun .
7575530	0	Bryostatin-1	31,43	TNF_alpha	73,82	Bryostatin-1	TNF alpha	MESH:C046785	7124	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|release release|nmod|END_ENTITY	The protein kinase C activator Bryostatin-1 induces the rapid release of TNF_alpha from MONO-MAC-6 cells .
10639596	0	Bryostatin_1	0,12	Bcl-2	66,71	Bryostatin 1	Bcl-2	MESH:C046785	596	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|degradation degradation|nmod|END_ENTITY	Bryostatin_1 induces ubiquitination and proteasome degradation of Bcl-2 in the human acute_lymphoblastic_leukemia cell line , Reh .
11961058	0	Bryostatin_1	0,12	cytochrome_c	65,77	Bryostatin 1	cytochrome c	MESH:C046785	54205	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|release release|amod|END_ENTITY	Bryostatin_1 increases 1-beta-D-arabinofuranosylcytosine-induced cytochrome_c release and apoptosis in human leukemia cells ectopically expressing Bcl-x -LRB- L -RRB- .
18175930	0	Brz220	0,6	DWF4	22,26	Brz220	DWF4	MESH:C459439	824229(Tax:3702)	Chemical	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Brz220 interacts with DWF4 , a cytochrome_P450_monooxygenase in brassinosteroid biosynthesis , and exerts biological activity .
22735757	0	Bucillamine	0,11	Akt	35,38	Bucillamine	Akt	MESH:C026535	11651(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|compound|END_ENTITY	Bucillamine inhibits CD40-mediated Akt activation and antibody production in mouse B-cell_lymphoma .
10678623	0	Budesonide	0,10	ICAM-1	34,40	Budesonide	ICAM-1	MESH:D019819	3383	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|expression expression|amod|END_ENTITY	Budesonide and formoterol inhibit ICAM-1 and VCAM-1 expression of human lung fibroblasts .
22558986	0	Budesonide	11,21	Smad4	25,30	Budesonide	Smad4	MESH:D019819	50554(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of Budesonide on Smad4 , PDGF-A and PAI-1 in a rat model of pulmonary_fibrosis -RSB- .
25722071	0	Budesonide	0,10	TLR4	21,25	Budesonide	TLR4	MESH:D019819	7099	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Budesonide increases TLR4 and TLR2 expression in Treg lymphocytes of allergic asthmatics .
20388003	0	Budesonide	0,10	Toll-like_receptor_2	20,40	Budesonide	Toll-like receptor 2	MESH:D019819	7097	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	Budesonide enhances Toll-like_receptor_2 expression in activated bronchial epithelial cells .
11864633	0	Budesonide	0,10	multidrug_resistance-associated_protein	19,58	Budesonide	multidrug resistance-associated protein	MESH:D019819	4363	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|iobj|END_ENTITY	Budesonide reduces multidrug_resistance-associated_protein 1 expression in an airway epithelial cell line -LRB- Calu-1 -RRB- .
11502275	0	Budesonide	0,10	vascular_endothelial_growth_factor	19,53	Budesonide	vascular endothelial growth factor	MESH:D019819	7422	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|secretion secretion|compound|END_ENTITY	Budesonide reduces vascular_endothelial_growth_factor secretion and expression in airway -LRB- Calu-1 -RRB- and alveolar -LRB- A549 -RRB- epithelial cells .
19592481	0	Bufalin	0,7	Bax	50,53	Bufalin	Bax	MESH:C022777	581	Chemical	Gene	Translocation|compound|START_ENTITY Translocation|compound|END_ENTITY	Bufalin Induces Reactive Oxygen Species Dependent Bax Translocation and Apoptosis in ASTC-a-1 Cells .
19417737	0	Bufalin	0,7	CYP3A4	17,23	Bufalin	CYP3A4	MESH:C022777	1576	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	Bufalin inhibits CYP3A4 activity in vitro and in vivo .
26111756	0	Bufalin	0,7	Mir-148a	124,132	Bufalin	Mir-148a	MESH:C022777	406940	Chemical	Gene	Inhibits|nsubj|START_ENTITY Inhibits|nmod|END_ENTITY	Bufalin Inhibits the Differentiation and Proliferation of Cancer Stem Cells Derived from Primary Osteosarcoma Cells through Mir-148a .
23087509	5	Buflomedil	697,707	VEGF	725,729	Buflomedil	VEGF	MESH:C010651	83785(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	The effects of Buflomedil on expression of VEGF and repair of neural pathology were also evaluated .
19297515	0	Bumetanide	0,10	NKCC1	15,20	Bumetanide	NKCC1	MESH:D002034	83629(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Bumetanide , an NKCC1 antagonist , does not prevent formation of epileptogenic focus but blocks epileptic focus seizures in immature rat hippocampus .
26960329	0	Bumetanide	40,50	NKCC1	24,29	Bumetanide	NKCC1	MESH:D002034	83629(Tax:10116)	Chemical	Gene	Neurogenesis|compound|START_ENTITY Neurogenesis|compound|END_ENTITY	Chloride Co-transporter NKCC1 Inhibitor Bumetanide Enhances Neurogenesis and Behavioral Recovery in Rats After Experimental Stroke .
8652636	0	Bumetanide	0,10	Ntcp	37,41	Bumetanide	Ntcp	MESH:D002034	24777(Tax:10116)	Chemical	Gene	transported|nsubjpass|START_ENTITY transported|nmod|END_ENTITY	Bumetanide is not transported by the Ntcp or by the oatp : evidence for a third organic_anion_transporter in rat liver cells .
18339158	0	Bupivacaine	0,11	COX-2	21,26	Bupivacaine	COX-2	MESH:D002045	19225(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Bupivacaine inhibits COX-2 expression , PGE2 , and cytokine production in endotoxin-activated macrophages .
9723124	0	Bupropion	0,9	dopamine_transporter	35,55	Bupropion	dopamine transporter	MESH:D016642	24898(Tax:10116)	Chemical	Gene	increase|amod|START_ENTITY END_ENTITY|nsubj|increase	Bupropion and desipramine increase dopamine_transporter mRNA expression in the ventral tegmental area/substantia nigra of rat brain .
6423662	0	Buserelin	138,147	GnRH	77,81	Buserelin	GnRH	MESH:D002064	2796	Chemical	Gene	GnRH_ethylamide|appos|START_ENTITY 6|appos|GnRH_ethylamide Absence|dep|6 Absence|nmod|effect effect|nmod|D-Ser D-Ser|appos|END_ENTITY	Absence of a direct inhibitory effect of the gonadotropin-releasing_hormone -LRB- GnRH -RRB- agonist D-Ser -LRB- TBU -RRB- 6 , des-Gly-NH2 -LRB- 10 -RRB- GnRH_ethylamide -LRB- Buserelin -RRB- on testicular steroidogenesis in men .
6427019	0	Buserelin	92,101	LH-RH	76,81	Buserelin	LH-RH	MESH:D002064	2796	Chemical	Gene	agonist|appos|START_ENTITY agonist|appos|END_ENTITY	Reversible hypogonadism induced by a luteinizing_hormone-releasing_hormone -LRB- LH-RH -RRB- agonist -LRB- Buserelin -RRB- as a new therapeutic approach for endometriosis .
12338631	0	Buserelin	25,34	LHRH	11,15	Buserelin	LHRH	MESH:D002064	2796	Chemical	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	Intranasal LHRH agonist -LRB- Buserelin -RRB- after ovulation : a post-coital contraceptive approach .
3140622	0	Buserelin	78,87	LHRH	65,69	Buserelin	LHRH	MESH:D002064	2796	Chemical	Gene	study|dep|START_ENTITY Treatment|dep|study Treatment|nmod|prostatic_cancer prostatic_cancer|nmod|administration administration|nmod|END_ENTITY	-LSB- Treatment of prostatic_cancer with intranasal administration of LHRH analog , Buserelin -LRB- Hoe_766 -RRB- study of the optimum dosage of intranasal application -RSB- .
6435703	0	Buserelin	68,77	LHRH	44,48	Buserelin	LHRH	MESH:D002064	2796	Chemical	Gene	treatment|appos|START_ENTITY agonist|dobj|treatment agonist|nsubj|effects effects|nmod|END_ENTITY	Anti-tumor and endocrine effects of chronic LHRH agonist treatment -LRB- Buserelin -RRB- with or without tamoxifen in premenopausal metastatic_breast_cancer .
6427019	0	Buserelin	92,101	luteinizing_hormone-releasing_hormone	37,74	Buserelin	luteinizing hormone-releasing hormone	MESH:D002064	2796	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Reversible hypogonadism induced by a luteinizing_hormone-releasing_hormone -LRB- LH-RH -RRB- agonist -LRB- Buserelin -RRB- as a new therapeutic approach for endometriosis .
7752194	0	Buspirone	0,9	5-HT1A_receptor	38,53	Buspirone	5-HT1A receptor	MESH:D002065	3350	Chemical	Gene	analogues|nsubj|START_ENTITY analogues|nmod|ligands ligands|nmod|END_ENTITY	Buspirone analogues as ligands of the 5-HT1A_receptor .
8985981	0	Buspirone	0,9	5-HT1A_receptor	38,53	Buspirone	5-HT1A receptor	MESH:D002065	3350	Chemical	Gene	analogues|nsubj|START_ENTITY analogues|nmod|ligands ligands|nmod|END_ENTITY	Buspirone analogues as ligands of the 5-HT1A_receptor .
2274641	0	Buspirone	0,9	5-HT1a_receptor	65,80	Buspirone	5-HT1a receptor	MESH:D002065	3350	Chemical	Gene	challenge|amod|START_ENTITY challenge|dep|evidence evidence|nmod|role role|nmod|function function|amod|END_ENTITY	Buspirone challenge : preliminary evidence for a role for central 5-HT1a_receptor function in impulsive_aggressive_behavior in humans .
2723131	0	Buspirone	0,9	prolactin	22,31	Buspirone	prolactin	MESH:D002065	5617	Chemical	Gene	START_ENTITY|dep|effects effects|nmod|END_ENTITY	Buspirone : effects on prolactin and growth_hormone as a function of drug level in generalized anxiety .
8038299	0	Buspirone	0,9	prolactin	18,27	Buspirone	prolactin	MESH:D002065	5617	Chemical	Gene	induced|nsubj|START_ENTITY induced|dobj|release release|compound|END_ENTITY	Buspirone induced prolactin release in mania .
11393587	0	Butein	0,6	Bcl-2	103,108	Butein	Bcl-2	MESH:C040918	596	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|expression expression|compound|END_ENTITY	Butein , a plant polyphenol , induces apoptosis concomitant with increased caspase-3 activity , decreased Bcl-2 expression and increased Bax expression in HL-60 cells .
20699088	0	Butein	0,6	CXCR4	40,45	Butein	CXCR4	MESH:C040918	7852	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|compound|END_ENTITY	Butein downregulates chemokine receptor CXCR4 expression and function through suppression of NF-kB activation in breast and pancreatic_tumor cells .
25533502	0	Butein	0,6	ICAM-1	18,24	Butein	ICAM-1	MESH:C040918	3383	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Butein suppresses ICAM-1 expression through the inhibition of IkBa and c-Jun phosphorylation in TNF-a - and PMA-treated HUVECs .
23499960	0	Butein	0,6	NF-kB	16,21	Butein	NF-kB	MESH:C040918	81736(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	Butein inhibits NF-kB activation and reduces infiltration of inflammatory cells and apoptosis after spinal_cord_injury in rats .
22722906	0	Butein	0,6	TGF-b	75,80	Butein	TGF-b	MESH:C040918	7040	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Butein inhibits ethanol-induced activation of liver stellate cells through TGF-b , NFkB , p38 , and JNK signaling pathways and inhibition of oxidative stress .
26694191	0	Butein	0,6	VEGF	68,72	Butein	VEGF	MESH:C040918	22339(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|expression expression|compound|END_ENTITY	Butein inhibits metastatic behavior in mouse melanoma cells through VEGF expression and translation-dependent signaling pathway regulation .
19560862	0	Butein	0,6	hTERT	85,90	Butein	hTERT	MESH:C040918	7015	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|transcription transcription|nmod|END_ENTITY	Butein suppresses c-Myc-dependent transcription and Akt-dependent phosphorylation of hTERT in human leukemia cells .
20696233	0	Butein	0,6	matrix_metalloproteinase-9	68,94	Butein	matrix metalloproteinase-9	MESH:C040918	4318	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|nmod|END_ENTITY	Butein suppresses the expression of nuclear factor-kappa B-mediated matrix_metalloproteinase-9 and vascular_endothelial_growth_factor in prostate_cancer cells .
25614461	0	Buthionine_sulfoximine	0,22	soluble_epoxide_hydrolase	88,113	Buthionine sulfoximine	soluble epoxide hydrolase	MESH:D019328	65030(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Buthionine_sulfoximine , an inhibitor of glutathione biosynthesis , induces expression of soluble_epoxide_hydrolase and markers of cellular hypertrophy in a rat cardiomyoblast cell line : Roles of the NF-kB and MAPK signaling pathways .
25211175	0	Butorphanol	0,11	Itch	37,41	Butorphanol	Itch	MESH:D002077	83737	Chemical	Gene	Suppression|amod|START_ENTITY Suppression|nmod|END_ENTITY	Butorphanol Suppression of Histamine Itch Is Mediated by Nucleus Accumbens and Septal Nuclei : A Pharmacological fMRI Study .
17320844	0	Butylated_hydroxyanisole	0,24	heme_oxygenase-1	36,52	Butylated hydroxyanisole	heme oxygenase-1	MESH:D002083	24451(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Butylated_hydroxyanisole stimulates heme_oxygenase-1 gene expression and inhibits neointima formation in rat arteries .
8740460	0	Butylated_hydroxyanisole	0,24	tumor_necrosis_factor-alpha	58,85	Butylated hydroxyanisole	tumor necrosis factor-alpha	MESH:D002083	7124	Chemical	Gene	blocks|nsubj|START_ENTITY blocks|dobj|effects effects|nmod|END_ENTITY	Butylated_hydroxyanisole blocks the inhibitory effects of tumor_necrosis_factor-alpha on collagen production in human dermal fibroblasts .
9721806	0	Butylated_hydroxytoluene	0,24	tumor_necrosis_factor-alpha	57,84	Butylated hydroxytoluene	tumor necrosis factor-alpha	MESH:D002084	7124	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|secretion secretion|amod|END_ENTITY	Butylated_hydroxytoluene and N-acetylcysteine attenuates tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- secretion and TNF-alpha mRNA expression in alveolar macrophages from human lung transplant recipients in vitro .
21553143	0	Butylidenephthalide	0,19	telomerase_reverse_transcriptase	37,69	Butylidenephthalide	telomerase reverse transcriptase	MESH:C026105	7015	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	Butylidenephthalide suppresses human telomerase_reverse_transcriptase -LRB- TERT -RRB- in human glioblastomas .
6728682	0	Butylphenyl_dGTP	0,16	DNA_polymerase_alpha	64,84	Butylphenyl dGTP	DNA polymerase alpha	MESH:C040364	5422	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	Butylphenyl_dGTP : a selective and potent inhibitor of mammalian DNA_polymerase_alpha .
9457899	0	Butyrate	0,8	BCLX	20,24	Butyrate	BCLX	MESH:D002087	598	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|amod|END_ENTITY	Butyrate attenuates BCLX -LRB- L -RRB- expression in human fibroblasts and acts in synergy with ionizing radiation to induce apoptosis .
23901348	0	Butyrate	67,75	CBP	0,3	Butyrate	CBP	MESH:D002087	1387	Chemical	Gene	Effects|nmod|START_ENTITY Effects|compound|END_ENTITY	CBP Activity Mediates Effects of the Histone Deacetylase Inhibitor Butyrate on WNT Activity and Apoptosis in Colon_Cancer Cells .
25310566	0	Butyrate	0,8	GPR41	154,159	Butyrate	GPR41	MESH:D002087	365228(Tax:10116)	Chemical	Gene	Levels|compound|START_ENTITY Levels|nmod|END_ENTITY	Butyrate Increases Intracellular Calcium Levels and Enhances Growth_Hormone Release from Rat Anterior Pituitary Cells via the G-Protein-Coupled Receptors GPR41 and 43 .
15063780	0	Butyrate	0,8	HDAC	67,71	Butyrate	HDAC	MESH:D002087	9734	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|inhibition inhibition|compound|END_ENTITY	Butyrate suppresses Cox-2 activation in colon_cancer cells through HDAC inhibition .
20004081	0	Butyrate	0,8	HDAC	84,88	Butyrate	HDAC	MESH:D002087	9734	Chemical	Gene	induced|dep|START_ENTITY induced|dobj|apoptosis apoptosis|nmod|activity activity|compound|END_ENTITY	Butyrate and propionate induced activated or non-activated neutrophil apoptosis via HDAC inhibitor activity but without activating GPR-41 / GPR-43 pathways .
20970954	0	Butyrate	0,8	HDAC	13,17	Butyrate	HDAC	MESH:D002087	9734	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Butyrate , an HDAC inhibitor , stimulates interplay between different posttranslational modifications of histone H3 and differently alters G1-specific cell cycle proteins in vascular smooth muscle cells .
23645985	0	Butyrate	0,8	IGF2	17,21	Butyrate	IGF2	MESH:D002087	281240(Tax:9913)	Chemical	Gene	Activation|compound|START_ENTITY Activation|compound|END_ENTITY	Butyrate Induced IGF2 Activation Correlated with Distinct Chromatin Signatures Due to Histone Modification .
11517158	0	Butyrate	0,8	IGF_binding_protein-3	63,84	Butyrate	IGF binding protein-3	MESH:D002087	3486	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|promoter promoter|compound|END_ENTITY	Butyrate , a histone deacetylase inhibitor , activates the human IGF_binding_protein-3 promoter in breast_cancer cells : molecular mechanism involves an Sp1/Sp3 multiprotein complex .
23086919	0	Butyrate	0,8	IL-23	19,24	Butyrate	IL-23	MESH:D002087	83430(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|production production|compound|END_ENTITY	Butyrate increases IL-23 production by stimulated dendritic cells .
20480520	0	Butyrate	0,8	IL-32alpha	20,30	Butyrate	IL-32alpha	MESH:D002087	9235	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	Butyrate stimulates IL-32alpha expression in human intestinal epithelial cell lines .
17805211	0	Butyrate	0,8	IL-8	56,60	Butyrate	IL-8	MESH:D002087	3576	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Butyrate regulates the expression of pathogen-triggered IL-8 in intestinal epithelia .
11989838	0	Butyrate	0,8	NF-kappaB	18,27	Butyrate	NF-kappaB	MESH:D002087	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	Butyrate inhibits NF-kappaB activation in lamina propria macrophages of patients with ulcerative_colitis .
15068815	0	Butyrate	0,8	VCAM-1	35,41	Butyrate	VCAM-1	MESH:D002087	7412	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Butyrate inhibits cytokine-induced VCAM-1 and ICAM-1 expression in cultured endothelial cells : the role of NF-kappaB and PPARalpha .
15168812	0	Butyrate	0,8	VCAM-1	76,82	Butyrate	VCAM-1	MESH:D002087	7412	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|cells cells|nmod|modulation modulation|nmod|END_ENTITY	Butyrate inhibits leukocyte adhesion to endothelial cells via modulation of VCAM-1 .
2590195	0	Butyrate	0,8	catalase	19,27	Butyrate	catalase	MESH:D002087	24248(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|activity activity|amod|END_ENTITY	Butyrate increases catalase activity and protects rat pulmonary artery smooth muscle cells against hyperoxia .
15025822	0	Butyrate	0,8	gamma_interferon	100,116	Butyrate	gamma interferon	MESH:D002087	15978(Tax:10090)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Butyrate enhances the production of nitric_oxide in mouse vascular endothelial cells in response to gamma_interferon .
12094619	0	Butyrate	0,8	glutathione_S-transferase	17,42	Butyrate	glutathione S-transferase	MESH:D002087	373156	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Butyrate induces glutathione_S-transferase in human colon cells and protects from genetic damage by 4-hydroxy-2-nonenal .
11575451	0	Butyrate	0,8	nuclear_factor-kappa_B	41,63	Butyrate	nuclear factor-kappa B	MESH:D002087	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	Butyrate inhibits interleukin-1-mediated nuclear_factor-kappa_B activation in human epithelial cells .
10821433	0	Butyrate	0,8	proliferating_cell_nuclear_antigen	40,74	Butyrate	proliferating cell nuclear antigen	MESH:D002087	25737(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Butyrate inhibits proliferation-induced proliferating_cell_nuclear_antigen expression -LRB- PCNA -RRB- in rat vascular smooth muscle cells .
16165221	0	Butyrate	0,8	tyrosine_hydroxylase	56,76	Butyrate	tyrosine hydroxylase	MESH:D002087	25085(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Butyrate , a gut-derived environmental signal , regulates tyrosine_hydroxylase gene expression via a novel promoter element .
11208715	0	Butyric_acid	0,12	Bax	48,51	Butyric acid	Bax	MESH:D020148	581	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|expression expression|compound|END_ENTITY	Butyric_acid induces apoptosis by up-regulating Bax expression via stimulation of the c-Jun N-terminal kinase/activation protein-1 pathway in human colon_cancer cells .
20587946	0	Butyric_acid	0,12	sialoprotein	29,41	Butyric acid	sialoprotein	MESH:D020148	64827(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|transcription transcription|compound|END_ENTITY	Butyric_acid stimulates bone sialoprotein gene transcription .
8395680	0	Butyrolactone_I	0,15	cdk2	42,46	Butyrolactone I	cdk2	MESH:C082868	12566(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|kinase kinase|amod|END_ENTITY	Butyrolactone_I , a selective inhibitor of cdk2 and cdc2 kinase .
10378783	0	Butyrolactone_I	0,15	cyclin_B1	24,33	Butyrolactone I	cyclin B1	MESH:C082868	891	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Butyrolactone_I induces cyclin_B1 and causes G2/M arrest and skipping of mitosis in human prostate cell lines .
24923102	0	Bydureon	1,9	GLP-1_receptor	29,43	Bydureon	GLP-1 receptor	MESH:C074031	2740	Chemical	Gene	START_ENTITY|dep|agonist agonist|compound|END_ENTITY	-LSB- Bydureon : first once weekly GLP-1_receptor agonist -LRB- exenatide LAR -RRB- -RSB- .
10090887	0	C	12,13	ABCR	30,34	C	ABCR	null	24	Chemical	Gene	mutation|compound|START_ENTITY mutation|nmod|gene gene|amod|END_ENTITY	The 2588G -- > C mutation in the ABCR gene is a mild frequent founder mutation in the Western European population and allows the classification of ABCR mutations in patients with Stargardt_disease .
17515904	6	C	695,696	BRCA2	689,694	C	RAD51	null	5888	Chemical	Gene	terminus|compound|START_ENTITY terminus|compound|END_ENTITY	Interaction of the BRCA2 C terminus with the RAD51 filament causes a large movement of the flexible RAD51 N-terminal domain that is important in regulating filament dynamics .
20947025	0	C	115,116	CD95	110,114	C	CD95	null	355	Chemical	Gene	terminus|compound|START_ENTITY terminus|compound|END_ENTITY	Solution NMR investigation of the CD95/FADD homotypic death domain complex suggests lack of engagement of the CD95 C terminus .
10065777	0	C	17,18	CYP17	36,41	C	CYP17	null	1586	Chemical	Gene	START_ENTITY|nmod|promoter promoter|compound|END_ENTITY	Polymorphism T -- > C -LRB- -34 bp -RRB- of gene CYP17 promoter in Greek patients with polycystic_ovary_syndrome .
19013303	0	C	19,20	CYP17	46,51	C	CYP17	null	1586	Chemical	Gene	START_ENTITY|nmod|promoter promoter|compound|END_ENTITY	Polymorphism T _ -- > _ C -LRB- -34 base pairs -RRB- of gene CYP17 promoter in women with polycystic_ovary_syndrome is associated with increased body weight and insulin resistance : a preliminary study .
17669272	0	C	57,58	Hsp70	74,79	C	Hsp70	null	44920(Tax:7227)	Chemical	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Overexpressed Drosophila DNA_methyltransferase_2 isoform C interacts with Hsp70 in vivo .
26803658	0	C	53,54	PKCa	58,62	C	PKCa	null	5578	Chemical	Gene	a|compound|START_ENTITY a|appos|END_ENTITY	CK1 kinase activity is modulated by protein kinase C a -LRB- PKCa -RRB- - mediated site-specific phosphorylation .
15728366	0	C	10,11	Rhodopsin	0,9	C	Rhodopsin	null	6010	Chemical	Gene	terminus|compound|START_ENTITY terminus|compound|END_ENTITY	Rhodopsin C terminus , the site of mutations causing retinal_disease , regulates trafficking by binding to ADP-ribosylation_factor_4 -LRB- ARF4 -RRB- .
10980191	0	C	105,106	Trp1	100,104	C	Trp1	null	7220	Chemical	Gene	terminus|compound|START_ENTITY terminus|compound|END_ENTITY	Expression of truncated transient receptor potential protein 1alpha -LRB- Trp1alpha -RRB- : evidence that the Trp1 C terminus modulates store-operated Ca2 + entry .
14500680	0	C	100,101	Tyk2	86,90	C	Tyk2	null	7297	Chemical	Gene	terminus|compound|START_ENTITY terminus|compound|END_ENTITY	Janus_kinase_2 activation by the platelet-activating_factor_receptor -LRB- PAFR -RRB- : roles of Tyk2 and PAFR C terminus .
16371349	0	C	89,90	UL44	64,68	C	UL44	null	3077460(Tax:10359)	Chemical	Gene	complex|nmod|START_ENTITY END_ENTITY|nmod|complex	Crystal structure of the cytomegalovirus DNA polymerase subunit UL44 in complex with the C terminus from the catalytic subunit .
16314503	0	C	23,24	Yku80	17,22	C	Yku80	null	855132(Tax:4932)	Chemical	Gene	terminus|compound|START_ENTITY terminus|compound|END_ENTITY	Mutations of the Yku80 C terminus and Xrs2 FHA domain specifically block yeast nonhomologous end joining .
18576678	0	C	46,47	angiotensin_I-converting_enzyme	64,95	C	angiotensin I-converting enzyme	null	1636	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Mapping of conformational mAb epitopes to the C domain of human angiotensin_I-converting_enzyme .
2174430	0	C	54,55	atrial_natriuretic_factor	69,94	C	atrial natriuretic factor	null	281355(Tax:9913)	Chemical	Gene	receptors|compound|START_ENTITY receptors|nmod|END_ENTITY	Cellular mechanisms of the clearance function of type C receptors of atrial_natriuretic_factor .
8688806	0	C	55,56	connectin	98,107	C	connectin	null	424126(Tax:9031)	Chemical	Gene	region|compound|START_ENTITY region|nmod|END_ENTITY	Molecular cloning of a partial cDNA clone encoding the C terminal region of chicken breast muscle connectin .
11967250	0	C	12,13	endothelial_nitric_oxide_synthase	26,59	C	endothelial nitric oxide synthase	null	4846	Chemical	Gene	mutation|compound|START_ENTITY mutation|nmod|END_ENTITY	The T-786 -- > C mutation in endothelial_nitric_oxide_synthase is associated with hypertension .
20140871	0	C	14,15	keratin_6A	32,42	C	keratin 6A	null	3853	Chemical	Gene	mutation|compound|START_ENTITY mutation|nmod|gene gene|amod|END_ENTITY	-LSB- The_521_T -- > _ C mutation in the keratin_6A gene in a pedigree with pachyonychia congenita type I -RSB- .
18039537	0	C-1-phosphonate	30,45	O-linked_GlcNAc_transferase	107,134	C-1-phosphonate	O-linked GlcNAc transferase	null	8473	Chemical	Gene	analogue|compound|START_ENTITY synthesis|nmod|analogue synthesis|nmod|END_ENTITY	A convenient synthesis of the C-1-phosphonate analogue of UDP-GlcNAc and its evaluation as an inhibitor of O-linked_GlcNAc_transferase -LRB- OGT -RRB- .
6705734	0	C-17_esters	19,30	estrogen_receptor	53,70	C-17 esters	estrogen receptor	null	2099	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	The interaction of C-17_esters of estradiol with the estrogen_receptor .
6822531	0	C-22-substituted_steroid	0,24	cytochrome_P-450scc	78,97	C-22-substituted steroid	cytochrome P-450scc	null	338048(Tax:9913)	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	C-22-substituted_steroid derivatives as substrate analogues and inhibitors of cytochrome_P-450scc .
23261425	0	C-5-methyl-cytosine	37,56	bcl-2	60,65	C-5-methyl-cytosine	bcl-2	null	596	Chemical	Gene	START_ENTITY|nmod|promoter promoter|amod|END_ENTITY	Stabilization of G-quadruplex DNA by C-5-methyl-cytosine in bcl-2 promoter : implications for epigenetic regulation .
24900297	0	C-Aryl_Glucoside	62,78	SGLT2	79,84	C-Aryl Glucoside	SGLT2	null	6524	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|compound|END_ENTITY	Synthesis and SAR of Thiazolylmethylphenyl_Glucoside as Novel C-Aryl_Glucoside SGLT2 Inhibitors .
26861002	0	C-Aryl_Glucoside	23,39	SGLT2	40,45	C-Aryl Glucoside	SGLT2	null	6524	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|compound|END_ENTITY	Recent Developments of C-Aryl_Glucoside SGLT2 Inhibitors .
20149653	0	C-Aryl_glycoside	0,16	SGLT2	31,36	C-Aryl glycoside	SGLT2	null	6524	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	C-Aryl_glycoside inhibitors of SGLT2 : Exploration of sugar modifications including C-5 spirocyclization .
23809172	0	C-Glucosides	0,12	sodium-dependent_glucose_cotransporter_2	48,88	C-Glucosides	sodium-dependent glucose cotransporter 2	null	246787(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	C-Glucosides with heteroaryl_thiophene as novel sodium-dependent_glucose_cotransporter_2 inhibitors .
23559491	0	C-H	106,109	TTF	126,129	C-H	TTF	null	399	Chemical	Gene	modification|amod|START_ENTITY modification|nmod|END_ENTITY	TIPS-TTF as a precursor of low-symmetry TTF derivatives : steric protection strategy in the regioselective C-H modification of TTF .
20000348	0	C-H	71,74	sp2	67,70	C-H	sp2	null	6668	Chemical	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Palladium-catalyzed alkoxylation of N-methoxybenzamides via direct sp2 C-H bond activation .
22572779	0	C-H	4,7	sp2	0,3	C-H	sp2	null	6668	Chemical	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	sp2 C-H activation of dimethyl_fumarate by a _ -LSB- -LRB- Cp * Co -RRB- 2 -_- -LRB- __ 4 _ : ___ 4-toluene -RRB- -RSB- complex .
19764750	0	C-H	39,42	sp3	35,38	C-H	sp3	null	6670	Chemical	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	A delicate balance between sp2 and sp3 C-H bond activation : a Pt -LRB- II -RRB- complex with a dual agostic interaction .
8632295	3	C-KIT	577,582	C-KIT	584,589	C-KIT	C-KIT	null	3815	Chemical	Gene	START_ENTITY|appos|+ +|compound|END_ENTITY	This study examines cells in the pyloric muscles of 23 patients -LRB- 16 with IHPS , 7 controls -RRB- for the presence of the C-KIT -LRB- C-KIT + -RRB- , using immunohistochemical techniques with antihuman C-KIT sera .
20952196	0	C-aryl_glucoside	43,59	SGLT2	60,65	C-aryl glucoside	SGLT2	null	6524	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Pyrimidinylmethylphenyl_glucoside as novel C-aryl_glucoside SGLT2 inhibitors .
21193308	0	C-aryl_glucoside	53,69	SGLT2	84,89	C-aryl glucoside	SGLT2	null	6524	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Exploration of SAR regarding glucose moiety in novel C-aryl_glucoside inhibitors of SGLT2 .
23605639	0	C-aryl_glucoside	89,105	SGLT2	106,111	C-aryl glucoside	SGLT2	null	6524	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Optimization of Gaussian Kernel Function in Support Vector Machine aided QSAR studies of C-aryl_glucoside SGLT2 inhibitors .
22507206	0	C-glucoside	46,57	SGLT2	147,152	C-glucoside	SGLT2	null	64522(Tax:10116)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Discovery of Ipragliflozin -LRB- ASP1941 -RRB- : a novel C-glucoside with benzothiophene structure as a potent and selective sodium_glucose co-transporter 2 -LRB- SGLT2 -RRB- inhibitor for the treatment of type_2_diabetes_mellitus .
10853664	0	C-glycosides	49,61	neuraminidase	14,27	C-glycosides	neuraminidase	CHEBI:20857	4758	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of neuraminidase with neuraminic acid C-glycosides .
22818040	0	C-indolylxylosides	45,63	sodium-dependent_glucose_co-transporter_2	67,108	C-indolylxylosides	sodium-dependent glucose co-transporter 2	null	64522(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Synthesis and biological evaluation of novel C-indolylxylosides as sodium-dependent_glucose_co-transporter_2 inhibitors .
12749866	0	C2-ceramide	93,104	PKC_delta	80,89	C2-ceramide	PKC delta	MESH:C064769	5580	Chemical	Gene	resistance|compound|START_ENTITY END_ENTITY|nmod|resistance	Characterization of C2-ceramide-resistant HL-60 subline -LRB- HL-CR -RRB- : involvement of PKC_delta in C2-ceramide resistance .
24106788	0	C2F4	48,52	CF2	63,66	C2F4	CF2	CHEBI:38866	537	Chemical	Gene	study|nmod|START_ENTITY END_ENTITY|nsubj|study	Experimental and modeling study of the reaction C2F4 -LRB- + M -RRB- CF2 + CF2 -LRB- + M -RRB- .
20534488	0	C2H2	74,78	Early_Endosomal_Autoantigen_1	94,123	C2H2	Early Endosomal Autoantigen 1	CHEBI:27518	8411	Chemical	Gene	finger|compound|START_ENTITY finger|nmod|END_ENTITY	Structural basis for Rab GTPase recognition and endosome tethering by the C2H2 zinc finger of Early_Endosomal_Autoantigen_1 -LRB- EEA1 -RRB- .
12808046	0	C2H2	33,37	UNC-98	23,29	C2H2	UNC-98	CHEBI:27518	181020(Tax:6239)	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	Caenorhabditis_elegans UNC-98 , a C2H2 Zn finger protein , is a novel partner of UNC-97 / PINCH in muscle adhesion complexes .
21599657	0	C2H2	16,20	ZNF580	0,6	C2H2	ZNF580	CHEBI:27518	51157	Chemical	Gene	factor|compound|START_ENTITY END_ENTITY|appos|factor	ZNF580 , a novel C2H2 zinc-finger transcription factor , interacts with the TGF-b signal molecule Smad2 .
26873583	0	C2_ceramide	12,23	heme_oxygenase-1	32,48	C2 ceramide	heme oxygenase-1	MESH:C064769	24451(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Short-chain C2_ceramide induces heme_oxygenase-1 expression by upregulating AMPK and MAPK signaling pathways in rat primary astrocytes .
24742960	0	C4-dicarboxylate	14,30	Asuc_0304	44,53	C4-dicarboxylate	Asuc_0304	CHEBI:61336	5348667(Tax:339671)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	A Na + - coupled C4-dicarboxylate transporter -LRB- Asuc_0304 -RRB- and aerobic growth of Actinobacillus_succinogenes on C4-dicarboxylates .
26669318	0	C4_phosphoenolpyruvate	94,116	PEPC	130,134	C4 phosphoenolpyruvate	PEPC	null	542372(Tax:4577)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Erratum to : Drought tolerance and proteomics studies of transgenic wheat containing the maize C4_phosphoenolpyruvate carboxylase -LRB- PEPC -RRB- gene .
21671595	0	C60	84,87	ML4	65,68	C60	ML4	CHEBI:33128	57192	Chemical	Gene	complexes|nmod|START_ENTITY complexes|compound|END_ENTITY	Computational study of cycloaddition reactions of 16-electron d8 ML4 complexes with C60 .
24746574	0	C646	0,4	p300	72,76	C646	p300	null	2033	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	C646 , a selective small molecule inhibitor of histone acetyltransferase p300 , radiosensitizes lung_cancer cells by enhancing mitotic catastrophe .
21036040	0	C9-triazole	46,57	neuraminidase_3	20,35	C9-triazole	neuraminidase 3	null	10825	Chemical	Gene	derivatives|compound|START_ENTITY Inhibition|nmod|derivatives Inhibition|nmod|END_ENTITY	Inhibition of human neuraminidase_3 -LRB- NEU3 -RRB- by C9-triazole derivatives of 2,3-didehydro-N-acetyl-neuraminic _ acid .
23865807	0	C99	68,71	amyloid_precursor_protein	86,111	C99	amyloid precursor protein	null	351	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Competition between homodimerization and cholesterol binding to the C99 domain of the amyloid_precursor_protein .
12437121	0	CA-074	0,6	cathepsin_B	71,82	CA-074	cathepsin B	MESH:C068250	13030(Tax:10090)	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	CA-074 , but not its methyl_ester_CA-074Me , is a selective inhibitor of cathepsin_B within living cells .
7612192	0	CA-074	59,65	cathepsin_B	78,89	CA-074	cathepsin B	MESH:C068250	1508	Chemical	Gene	Assessment|nmod|START_ENTITY Assessment|acl|activity activity|amod|END_ENTITY	Assessment of cathepsin_L activity by use of the inhibitor CA-074 compared to cathepsin_B activity in human lung_tumor tissue .
23748042	0	CA-074Me	0,8	cathepsin_B	12,23	CA-074Me	cathepsin B	MESH:C400541	64529(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	CA-074Me , a cathepsin_B inhibitor , decreases APP accumulation and protects primary rat cortical neurons treated with okadaic_acid .
3482661	3	CA-125	465,471	IAP	417,420	CA-125	IAP	null	3375	Chemical	Gene	START_ENTITY|nsubj|sensitivity sensitivity|nmod|END_ENTITY	The sensitivity of IAP in detecting ovarian_cancer was higher than CA-125 -LRB- 83.4 % versus 76.7 % -RRB- .
9192742	0	CA074	16,21	cathepsin_B	68,79	CA074	cathepsin B	MESH:C068250	281105(Tax:9913)	Chemical	Gene	mode|nmod|START_ENTITY mode|nmod|END_ENTITY	Binding mode of CA074 , a specific irreversible inhibitor , to bovine cathepsin_B as determined by X-ray crystal analysis of the complex .
16750360	0	CA224	0,5	Cdk4	54,58	CA224	Cdk4	MESH:C513950	1019	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	CA224 , a non-planar analogue of fascaplysin , inhibits Cdk4 but not Cdk2 and arrests cells at G0/G1 inhibiting pRB phosphorylation .
25368960	0	CA224	66,71	Cdk4	120,124	CA224	Cdk4	MESH:C513950	1019	Chemical	Gene	methylamide|appos|START_ENTITY methylamide|appos|analogue analogue|nmod|END_ENTITY	Biphenyl-4-carboxylic_acid -LSB- 2 - -LRB- 1H-indol-3-yl -RRB- - ethyl -RSB- - methylamide -LRB- CA224 -RRB- , a nonplanar analogue of fascaplysin , inhibits Cdk4 and tubulin polymerization : evaluation of in vitro and in vivo anticancer activity .
9219428	0	CAA	26,29	trnL	21,25	CAA	trnL	CHEBI:27869	3429338(Tax:3659)	Chemical	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cucumber chloroplast trnL -LRB- CAA -RRB- gene : nucleotide sequence and in vivo expression analysis in etiolated cucumber seedlings treated with benzyladenine and light .
20959606	0	CAL-101	0,7	p110delta	11,20	CAL-101	p110delta	MESH:C552946	5293	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	CAL-101 , a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies , inhibits PI3K signaling and cellular viability .
25472266	0	CALCIUM	27,34	NCKX3	76,81	CALCIUM	NCKX3	MESH:D002118	94249(Tax:10090)	Chemical	Gene	EXPRESSION|nmod|START_ENTITY TRANSPORT|nsubj|EXPRESSION TRANSPORT|dobj|CaBP-9k CaBP-9k|appos|END_ENTITY	218 DISTINCT EXPRESSION OF CALCIUM TRANSPORT CHANNELS , TRPV5 , TRPV6 , PMCA1 , NCKX3 , AND CaBP-9k IN THE DUODENUM , KIDNEY , AND PLACENTA DURING PREGNANCY .
25472266	0	CALCIUM	27,34	PMCA1	69,74	CALCIUM	PMCA1	MESH:D002118	67972(Tax:10090)	Chemical	Gene	EXPRESSION|nmod|START_ENTITY TRANSPORT|nsubj|EXPRESSION TRANSPORT|dobj|CaBP-9k CaBP-9k|appos|END_ENTITY	218 DISTINCT EXPRESSION OF CALCIUM TRANSPORT CHANNELS , TRPV5 , TRPV6 , PMCA1 , NCKX3 , AND CaBP-9k IN THE DUODENUM , KIDNEY , AND PLACENTA DURING PREGNANCY .
25472266	0	CALCIUM	27,34	TRPV5	55,60	CALCIUM	TRPV5	MESH:D002118	194352(Tax:10090)	Chemical	Gene	EXPRESSION|nmod|START_ENTITY TRANSPORT|nsubj|EXPRESSION TRANSPORT|dobj|CaBP-9k CaBP-9k|appos|END_ENTITY	218 DISTINCT EXPRESSION OF CALCIUM TRANSPORT CHANNELS , TRPV5 , TRPV6 , PMCA1 , NCKX3 , AND CaBP-9k IN THE DUODENUM , KIDNEY , AND PLACENTA DURING PREGNANCY .
25472266	0	CALCIUM	27,34	TRPV6	62,67	CALCIUM	TRPV6	MESH:D002118	64177(Tax:10090)	Chemical	Gene	EXPRESSION|nmod|START_ENTITY TRANSPORT|nsubj|EXPRESSION TRANSPORT|dobj|CaBP-9k CaBP-9k|appos|END_ENTITY	218 DISTINCT EXPRESSION OF CALCIUM TRANSPORT CHANNELS , TRPV5 , TRPV6 , PMCA1 , NCKX3 , AND CaBP-9k IN THE DUODENUM , KIDNEY , AND PLACENTA DURING PREGNANCY .
26527775	0	CALGB_40601	106,117	Epidermal_Growth_Factor_Receptor_2	58,92	CALGB 40601	Epidermal Growth Factor Receptor 2	null	2064	Chemical	Gene	Targeting|nmod|START_ENTITY Targeting|compound|END_ENTITY	Molecular Heterogeneity and Response to Neoadjuvant Human Epidermal_Growth_Factor_Receptor_2 Targeting in CALGB_40601 , a Randomized Phase III Trial of Paclitaxel Plus Trastuzumab With or Without Lapatinib .
12887090	0	CAMP	0,4	Epac	133,137	CAMP	Epac	CHEBI:17489	223864(Tax:10090)	Chemical	Gene	activates|nsubj|START_ENTITY activates|parataxis|mediated mediated|nmod|END_ENTITY	CAMP activates Rap1 in differentiating mouse male germ cells : a new signaling pathway mediated by the cAMP-activated exchange factor Epac ?
12887090	0	CAMP	0,4	Rap1	15,19	CAMP	Rap1	CHEBI:17489	109905(Tax:10090)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	CAMP activates Rap1 in differentiating mouse male germ cells : a new signaling pathway mediated by the cAMP-activated exchange factor Epac ?
15690129	0	CAY10404	49,57	Cox-2	78,83	CAY10404	Cox-2	MESH:C501048	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Inhibition of human neuroblastoma cell growth by CAY10404 , a highly selective Cox-2 inhibitor .
18855964	0	CAY10499	0,8	monoglyceride_lipase	18,38	CAY10499	monoglyceride lipase	MESH:C534918	11343	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	CAY10499 , a novel monoglyceride_lipase inhibitor evidenced by an expeditious MGL assay .
23793974	0	CAY10593	0,8	P2X7_receptor	28,41	CAY10593	P2X7 receptor	null	5027	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	CAY10593 inhibits the human P2X7_receptor independently of phospholipase_D1 stimulation .
2009862	0	CArG	122,126	SRF	151,154	CArG	SRF	null	394277(Tax:8355)	Chemical	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Expression of genes encoding the transcription factor SRF during early development of Xenopus_laevis : identification of a CArG box-binding activity as SRF .
104407	0	CB-154	37,43	growth_hormone	9,23	CB-154	growth hormone	MESH:D001971	2688	Chemical	Gene	responses|nmod|START_ENTITY responses|compound|END_ENTITY	Abnormal growth_hormone responses to CB-154 and thyrotropin-releasing_hormone -LRB- TRH -RRB- in patients with acromegaly .
1127079	0	CB-154	113,119	growth_hormone	27,41	CB-154	growth hormone	MESH:D001971	2688	Chemical	Gene	administration|nmod|START_ENTITY END_ENTITY|nmod|administration	Stable reduction of plasma growth_hormone -LRB- hGH -RRB- levels during chronic administration of 2-Br-alpha-ergocryptine -LRB- CB-154 -RRB- in acromegalic patients .
8571380	0	CB-77	45,50	transthyretin	72,85	CB-77	transthyretin	null	22139(Tax:10090)	Chemical	Gene	metabolite|appos|START_ENTITY metabolite|nmod|END_ENTITY	Binding of a 3,3 ' , _ 4,4 ' - tetrachlorobiphenyl -LRB- CB-77 -RRB- metabolite to fetal transthyretin and effects on fetal thyroid hormone levels in mice .
16129418	0	CB1954	72,78	quinone_reductase_2	21,40	CB1954	quinone reductase 2	MESH:C100099	4835	Chemical	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Crystal structure of quinone_reductase_2 in complex with cancer prodrug CB1954 .
20609415	0	CB30865	54,61	Nampt	31,36	CB30865	Nampt	MESH:C403613	10135	Chemical	Gene	target|nmod|START_ENTITY END_ENTITY|nmod|target	Chemical proteomics identifies Nampt as the target of CB30865 , an orphan cytotoxic compound .
8627573	0	CB30900	28,35	thymidylate_synthase	68,88	CB30900	thymidylate synthase	MESH:C099176	22171(Tax:10090)	Chemical	Gene	pharmacology|nmod|START_ENTITY pharmacology|appos|inhibitor inhibitor|nmod|END_ENTITY	Preclinical pharmacology of CB30900 , a novel dipeptide inhibitor of thymidylate_synthase , in mice .
8787544	0	CB30900	157,164	thymidylate_synthase	49,69	CB30900	thymidylate synthase	MESH:C099176	22171(Tax:10090)	Chemical	Gene	tomudex|appos|START_ENTITY effect|nmod|tomudex dUMP|dep|effect dUMP|nmod|index index|nmod|inhibition inhibition|amod|END_ENTITY	Immunoreactive dUMP and TTP pools as an index of thymidylate_synthase inhibition ; effect of tomudex -LRB- ZD1694 -RRB- and a nonpolyglutamated quinazoline_antifolate -LRB- CB30900 -RRB- in L1210 mouse leukaemia cells .
25060070	0	CBB1003	0,7	lysine-specific_demethylase_1	11,40	CBB1003	lysine-specific demethylase 1	null	23028	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	CBB1003 , a lysine-specific_demethylase_1 inhibitor , suppresses colorectal_cancer cells growth through down-regulation of leucine-rich_repeat-containing_G-protein-coupled_receptor_5 expression .
22587944	0	CBIO	58,62	D-amino_acid_oxidase	27,47	CBIO	D-amino acid oxidase	null	1610	Chemical	Gene	START_ENTITY|nsubj|Interactions Interactions|nmod|inhibitor inhibitor|amod|END_ENTITY	Interactions of the potent D-amino_acid_oxidase inhibitor CBIO with morphine in pain and tolerance to analgesia .
26476243	0	CBLB502	0,7	Toll-like_receptor_5	23,43	CBLB502	Toll-like receptor 5	MESH:C528306	53791(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonist agonist|nmod|END_ENTITY	CBLB502 , an agonist of Toll-like_receptor_5 , has antioxidant and scavenging free radicals activities in vitro .
21841164	0	CBS9106	0,7	CRM1	35,39	CBS9106	CRM1	MESH:C568326	103573(Tax:10090)	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|compound|END_ENTITY	CBS9106 is a novel reversible oral CRM1 inhibitor with CRM1 degrading activity .
23594135	6	CBX	949,952	Hsp70	930,935	CBX	Hsp70	null	3308	Chemical	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	We demonstrate further that Hsp70 induction by CBX arises from activation of heat_shock factor 1 -LRB- HSF1 -RRB- .
21172267	0	CC-10004	0,8	TNF-a	86,91	CC-10004	TNF-a	MESH:C505730	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	CC-10004 but not thalidomide or lenalidomide inhibits lamina propria mononuclear cell TNF-a and MMP-3 production in patients with inflammatory_bowel_disease .
17308870	0	CC-4047	22,29	cyclooxygenase_2	97,113	CC-4047	cyclooxygenase 2	MESH:C467566	5743	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Immunomodulatory drug CC-4047 is a cell-type and stimulus-selective transcriptional inhibitor of cyclooxygenase_2 .
22244937	0	CC-930	13,19	JNK	52,55	CC-930	JNK	MESH:C570789	116554(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Discovery of CC-930 , an orally active anti-fibrotic JNK inhibitor .
26351918	0	CCCP	121,125	Melanoma_differentiation-associated_gene_5	0,42	CCCP	Melanoma differentiation-associated gene 5	MESH:D002258	64135	Chemical	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	Melanoma_differentiation-associated_gene_5 is involved in the induction of stress granules and autophagy by protonophore CCCP .
26295164	0	CCG-1423	37,45	Myocardin-Related_Transcription_Factor_A	81,121	CCG-1423	Myocardin-Related Transcription Factor A	MESH:C523455	223701(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Mediated|nsubj|Effects Mediated|nmod|END_ENTITY	Stereospecific Inhibitory Effects of CCG-1423 on the Cellular Events Mediated by Myocardin-Related_Transcription_Factor_A .
11410517	0	CCI-779	65,72	mTOR	26,30	CCI-779	mTOR	MESH:C401859	21977(Tax:10090)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|correlates correlates|nmod|END_ENTITY	Biochemical correlates of mTOR inhibition by the rapamycin_ester CCI-779 and tumor growth inhibition .
11566616	0	CCI-779	53,60	mTOR	0,4	CCI-779	mTOR	MESH:C401859	21977(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY target|dep|effect END_ENTITY|appos|target	mTOR , a novel target in breast_cancer : the effect of CCI-779 , an mTOR inhibitor , in preclinical models of breast_cancer .
11566616	0	CCI-779	53,60	mTOR	65,69	CCI-779	mTOR	MESH:C401859	21977(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY target|dep|effect mTOR|appos|target mTOR|appos|inhibitor inhibitor|compound|END_ENTITY	mTOR , a novel target in breast_cancer : the effect of CCI-779 , an mTOR inhibitor , in preclinical models of breast_cancer .
15136596	0	CCI-779	81,88	mTOR	98,102	CCI-779	mTOR	MESH:C401859	21977(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Safety and pharmacokinetics of escalated doses of weekly intravenous infusion of CCI-779 , a novel mTOR inhibitor , in patients with cancer .
15304393	0	CCI-779	48,55	mTOR	33,37	CCI-779	mTOR	MESH:C401859	21977(Tax:10090)	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|effects effects|nmod|END_ENTITY	In vivo antitumor effects of the mTOR inhibitor CCI-779 against human multiple_myeloma cells in a xenograft model .
15955899	0	CCI-779	32,39	mTOR	63,67	CCI-779	mTOR	MESH:C401859	21977(Tax:10090)	Chemical	Gene	temsirolimus|appos|START_ENTITY study|nmod|temsirolimus study|appos|inhibitor inhibitor|nmod|END_ENTITY	Phase II study of temsirolimus -LRB- CCI-779 -RRB- , a novel inhibitor of mTOR , in heavily pretreated patients with locally advanced or metastatic breast_cancer .
16331623	0	CCI-779	47,54	mTOR	32,36	CCI-779	mTOR	MESH:C401859	21977(Tax:10090)	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|effect effect|nmod|END_ENTITY	In vivo antitumor effect of the mTOR inhibitor CCI-779 and gemcitabine in xenograft models of human pancreatic_cancer .
18413763	0	CCI-779	30,37	mTOR	80,84	CCI-779	mTOR	MESH:C401859	21977(Tax:10090)	Chemical	Gene	action|nmod|START_ENTITY involves|nsubj|action involves|dobj|inhibition inhibition|nmod|activity activity|compound|END_ENTITY	A new pharmacologic action of CCI-779 involves FKBP12-independent inhibition of mTOR kinase activity and profound repression of global protein synthesis .
23537100	0	CCI-779	25,32	mTOR	104,108	CCI-779	mTOR	MESH:C401859	21977(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|inhibition inhibition|nmod|END_ENTITY	The novel mTOR inhibitor CCI-779 -LRB- temsirolimus -RRB- induces antiproliferative effects through inhibition of mTOR in Bel-7402 liver_cancer cells .
22320865	0	CCI-779	57,64	mammalian_target_of_rapamycin	14,43	CCI-779	mammalian target of rapamycin	MESH:C401859	2475	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Inhibition of mammalian_target_of_rapamycin signaling by CCI-779 -LRB- temsirolimus -RRB- induces growth inhibition and cell cycle arrest in Cashmere goat fetal fibroblasts -LRB- Capra_hircus -RRB- .
17145584	0	CCI779	32,38	mTOR	55,59	CCI779	mTOR	MESH:C401859	21977(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	-LSB- Update on clinical activity of CCI779 -LRB- temsirolimus -RRB- , mTOR inhibitor -RSB- .
1683622	0	CCK-33	36,42	CCK	28,31	CCK-33	CCK	MESH:D002766	885	Chemical	Gene	polypeptide|amod|START_ENTITY polypeptide|appos|END_ENTITY	Effects of cholecystokinin -LRB- CCK -RRB- -8 , CCK-33 , and gastric inhibitory polypeptide -LRB- GIP -RRB- on basal and meal-stimulated pancreatic hormone secretion in man .
8919664	0	CCK-33	66,72	Cholecystokinin	0,15	CCK-33	Cholecystokinin	MESH:D002766	25298(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|dep|effects	Cholecystokinin -LRB- CCK -RRB- and C-terminal fragments of CCK : effects of CCK-33 , CCK-8 and CCK-4 in the cardiovascular system of diabetic rats .
2485904	0	CCK-33	28,34	cholecystokinin	11,26	CCK-33	cholecystokinin	MESH:D002766	25298(Tax:10116)	Chemical	Gene	_|appos|START_ENTITY _|compound|END_ENTITY	Effects of cholecystokinin _ -LRB- CCK-33 -RRB- and its fragments , C-terminal octapeptide -LRB- CCK-8 -RRB- and C-terminal tetrapeptide -LRB- CCK-4 -RRB- , on the circulatory system of diabetic rats .
6204542	0	CCK-33	72,78	cholecystokinin	15,30	CCK-33	cholecystokinin	MESH:D002766	25298(Tax:10116)	Chemical	Gene	potent|nmod|START_ENTITY analogues|parataxis|potent analogues|nsubj|Bioactivity Bioactivity|nmod|END_ENTITY	Bioactivity of cholecystokinin analogues : CCK-8 is not more potent than CCK-33 .
26883191	0	CCL-34	0,6	toll-like_receptor_4	20,40	CCL-34	toll-like receptor 4	MESH:C570114	7099	Chemical	Gene	START_ENTITY|appos|activator activator|amod|END_ENTITY	CCL-34 , a synthetic toll-like_receptor_4 activator , modulates differentiation and maturation of myeloid dendritic cells .
21885865	0	CCT137690	28,37	MYCN	52,56	CCT137690	MYCN	MESH:C551619	4613	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	The aurora kinase inhibitor CCT137690 downregulates MYCN and sensitizes MYCN-amplified neuroblastoma in vivo .
21239475	0	CCT241533	0,9	CHK2	49,53	CCT241533	CHK2	MESH:C556313	11200	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	CCT241533 is a potent and selective inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors .
22929806	0	CCT244747	0,9	CHK1	42,46	CCT244747	CHK1	MESH:C577959	1111	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|compound|END_ENTITY	CCT244747 is a novel potent and selective CHK1 inhibitor with oral efficacy alone and in combination with genotoxic anticancer drugs .
26295308	0	CCT245737	35,44	CHK1	65,69	CCT245737	CHK1	null	1111	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|compound|END_ENTITY	The clinical development candidate CCT245737 is an orally active CHK1 inhibitor with preclinical activity in RAS mutant NSCLC and E - MYC driven B-cell_lymphoma .
26268910	0	CCX140-B	29,37	CCR2	14,18	CCX140-B	CCR2	null	729230	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|effect effect|nmod|END_ENTITY	The effect of CCR2 inhibitor CCX140-B on residual albuminuria in patients with type 2 diabetes and nephropathy : a randomised trial .
22589376	0	CCX354-C	35,43	CCR1	19,23	CCX354-C	CCR1	null	1230	Chemical	Gene	treatment|compound|START_ENTITY treatment|compound|END_ENTITY	Chemokine receptor CCR1 antagonist CCX354-C treatment for rheumatoid_arthritis : CARAT-2 , a randomised , placebo controlled clinical trial .
12889522	0	CCl4	86,90	Retinol_binding_protein	0,23	CCl4	Retinol binding protein	CHEBI:27385	25703(Tax:10116)	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|END_ENTITY	Retinol_binding_protein in plasma to evaluate the hepatotoxicity of rats treated with CCl4 .
12579868	1	CCl4	206,210	mice	320,324	CCl4	CCl4	CHEBI:27385	20303(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nmod|END_ENTITY	AIM : To study the protective effect of Gn-3 -LRB- a stilbene polymer isolated from Gnetum_parvifolium -RRB- against liver_injury induced by CCl4 , N-acetyl-p-aminophenol -LRB- APAP -RRB- and Bacillus Calmette-Guerin -LRB- BCG -RRB- plus bacterial lipopolysaccharide -LRB- LPS -RRB- in mice .
2167684	0	CD-349	55,61	calmodulin	68,78	CD-349	calmodulin	MESH:C054179	808	Chemical	Gene	Interaction|amod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of the dihydropyridine_calcium antagonist , CD-349 , with calmodulin .
21105040	3	CD127	468,473	CD4	494,497	CD127	CD4	null	920	Chemical	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	Here , we demonstrated that CD127 in combination with CD4 and CD25 can identify FoxP3 -LRB- + -RRB- Treg in peripheral blood -LRB- PB -RRB- and bone marrow -LRB- BM -RRB- using multicolor flow cytometry .
15922728	0	CD437	0,5	JNK	177,180	CD437	JNK	MESH:C099555	5599	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	CD437 , a synthetic retinoid , induces apoptosis in human respiratory epithelial cells via caspase-independent mitochondrial and caspase-8-dependent pathways both up-regulated by JNK signaling pathway .
19018770	0	CD437	74,79	thioredoxin-binding_protein_2	15,44	CD437	thioredoxin-binding protein 2	MESH:C099555	10628	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of thioredoxin-binding_protein_2 in the antitumor activity of CD437 .
18216291	0	CDB-2914	32,40	extracellular_matrix_metalloproteinase_inducer	49,95	CDB-2914	extracellular matrix metalloproteinase inducer	MESH:C094854	682	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Progesterone_receptor modulator CDB-2914 induces extracellular_matrix_metalloproteinase_inducer in cultured human uterine_leiomyoma cells .
21119048	0	CDB-4124	0,8	progesterone_receptor	12,33	CDB-4124	progesterone receptor	MESH:C461063	5241	Chemical	Gene	START_ENTITY|appos|modulator modulator|compound|END_ENTITY	CDB-4124 , a progesterone_receptor modulator , inhibits mammary carcinogenesis by suppressing cell proliferation and inducing apoptosis .
19189297	0	CDDO-Me	22,29	Akt	133,136	CDDO-Me	Akt	MESH:C445068	207	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	Oleanane triterpenoid CDDO-Me inhibits growth and induces apoptosis in prostate_cancer cells by independently targeting pro-survival Akt and mTOR .
22177954	0	CDDO-Me	22,29	Akt	39,42	CDDO-Me	Akt	MESH:C445068	207	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	Oleanane triterpenoid CDDO-Me inhibits Akt activity without affecting PDK1 kinase or PP2A phosphatase activity in cancer cells .
24088953	0	CDDO-imidazolide	33,49	Nrf2	4,8	CDDO-imidazolide	Nrf2	null	18024(Tax:10090)	Chemical	Gene	activator|appos|START_ENTITY activator|amod|END_ENTITY	The Nrf2 triterpenoid activator , CDDO-imidazolide , protects kidneys from ischemia-reperfusion injury in mice .
2584809	0	CDDP	158,162	ACR	168,171	CDDP	ACR	null	49	Chemical	Gene	START_ENTITY|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- CDDP-ACR treatment in patients with recurrent ovarian_cancer with prior chemotherapy containing CDDP -- a preliminary study of a 14-day continuous infusion of CDDP with ACR -RSB- .
11432351	0	CDDP	94,98	CPT-11	85,91	CDDP	CPT-11	null	963084(Tax:115711)	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- A case of advanced gastric_cancer treated with neoadjuvant chemotherapy of low-dose CPT-11 + CDDP -RSB- .
18408436	0	CDDP	133,137	S-1	81,84	CDDP	S-1	null	5707	Chemical	Gene	-RSB-|compound|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- A case of unresectable advanced gallbladder_cancer successfully treated by oral S-1 and hepatic arterial infusion -LRB- HAI -RRB- of low-dose CDDP therapy -RSB- .
26964156	0	CDDP	41,45	S-1	32,35	CDDP	S-1	null	5707	Chemical	Gene	Therapy|compound|START_ENTITY Therapy|compound|END_ENTITY	Complete Response Obtained with S-1 Plus CDDP Therapy in a Patient with Multiple Liver Metastases from Gastric_Cancer .
26540344	0	CDDP	30,34	p53	16,19	CDDP	p53	null	7157	Chemical	Gene	treatment|compound|START_ENTITY END_ENTITY|nmod|treatment	Ell3 stabilizes p53 following CDDP treatment via its effects on ubiquitin-dependent and - independent proteasomal degradation pathways in breast_cancer cells .
21484792	0	CDKI-71	0,7	CDK9	17,21	CDKI-71	CDK9	MESH:C569861	1025	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	CDKI-71 , a novel CDK9 inhibitor , is preferentially cytotoxic to cancer cells compared to flavopiridol .
9631241	0	CDP840	0,6	PDE-4	29,34	CDP840	PDE-4	MESH:C102660	5141	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	CDP840 : a novel inhibitor of PDE-4 .
9163639	0	CDP840	72,78	PDE4	46,50	CDP840	PDE4	MESH:C102660	5141	Chemical	Gene	effect|appos|START_ENTITY effect|nmod|inhibitor inhibitor|compound|END_ENTITY	The effect of a novel orally active selective PDE4 isoenzyme inhibitor -LRB- CDP840 -RRB- on allergen-induced responses in asthmatic subjects .
19627999	0	CDPPB	25,30	mGluR5	36,42	CDPPB	mGluR5	MESH:C494553	14805(Tax:10090)	Chemical	Gene	START_ENTITY|appos|modulator modulator|amod|END_ENTITY	Dose-dependent effect of CDPPB , the mGluR5 positive allosteric modulator , on recognition memory is associated with GluR1 and CREB phosphorylation in the prefrontal cortex and hippocampus .
25160573	0	CDPPB	42,47	mGluR5	4,10	CDPPB	mGluR5	MESH:C494553	14805(Tax:10090)	Chemical	Gene	modulator|appos|START_ENTITY modulator|amod|END_ENTITY	The mGluR5 positive allosteric modulator , CDPPB , ameliorates pathology and phenotypic signs of a mouse model of Huntington 's _ disease .
26407764	0	CE-103	24,30	dopamine_transporter	72,92	CE-103	dopamine transporter	null	24898(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	A heterocyclic compound CE-103 inhibits dopamine reuptake and modulates dopamine_transporter and dopamine D1-D3 containing receptor complexes .
9412490	0	CEP-1347	35,43	JNK	80,83	CEP-1347	JNK	MESH:C106592	116554(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|pathway pathway|compound|END_ENTITY	Motoneuron apoptosis is blocked by CEP-1347 -LRB- KT_7515 -RRB- , a novel inhibitor of the JNK signaling pathway .
11756493	0	CEP-1347	98,106	c-Jun_N-terminal_kinase	18,41	CEP-1347	c-Jun N-terminal kinase	MESH:C106592	5599	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Inhibition of the c-Jun_N-terminal_kinase signaling pathway by the mixed lineage kinase inhibitor CEP-1347 -LRB- KT7515 -RRB- preserves metabolism and growth of trophic factor-deprived neurons .
22203728	0	CEP-28122	0,9	anaplastic_lymphoma_kinase	68,94	CEP-28122	anaplastic lymphoma kinase	MESH:C573313	238	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	CEP-28122 , a highly potent and selective orally active inhibitor of anaplastic_lymphoma_kinase with antitumor activity in experimental models of human cancers .
22319199	0	CEP-32496	0,9	BRAF	33,37	CEP-32496	BRAF	MESH:C575620	673	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	CEP-32496 : a novel orally active BRAF -LRB- V600E -RRB- inhibitor with selective cellular and in vivo antitumor activity .
22334590	0	CEP-33779	24,33	JAK2	53,57	CEP-33779	JAK2	MESH:C567989	16452(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Therapeutic efficacy of CEP-33779 , a novel selective JAK2 inhibitor , in a mouse model of colitis-induced colorectal_cancer .
14726387	0	CEP-701	13,20	FLT3	30,34	CEP-701	FLT3	MESH:C119379	2322	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Single-agent CEP-701 , a novel FLT3 inhibitor , shows biologic and clinical activity in patients with relapsed or refractory acute_myeloid_leukemia .
20008298	0	CEP-701	17,24	JAK2	46,50	CEP-701	JAK2	MESH:C119379	3717	Chemical	Gene	study|nmod|START_ENTITY study|appos|inhibitor inhibitor|compound|END_ENTITY	Phase 2 study of CEP-701 , an orally available JAK2 inhibitor , in patients with primary or post-polycythemia vera/essential _ thrombocythemia_myelofibrosis .
9259409	0	CEP-751	0,7	TRK	17,20	CEP-751	TRK	MESH:C107558	18211(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	CEP-751 inhibits TRK receptor tyrosine kinase activity in vitro exhibits anti-tumor activity .
16232379	0	CERA	0,4	Erythropoietin	17,31	CERA	Erythropoietin	null	2056	Chemical	Gene	START_ENTITY|appos|Activator Activator|compound|END_ENTITY	CERA -LRB- Continuous Erythropoietin Receptor Activator -RRB- : a new erythropoiesis-stimulating agent for the treatment of anemia .
17164776	0	CERE-120	34,42	neurturin	21,30	CERE-120	neurturin	null	4902	Chemical	Gene	delivery|nmod|START_ENTITY delivery|nmod|END_ENTITY	Striatal delivery of neurturin by CERE-120 , an AAV2 vector for the treatment of dopaminergic neuron_degeneration in Parkinson 's _ disease .
15720820	0	CF101	0,5	A3_adenosine_receptor	25,46	CF101	A3 adenosine receptor	MESH:C478920	11542(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonist agonist|nmod|END_ENTITY	CF101 , an agonist to the A3_adenosine_receptor , enhances the chemotherapeutic effect of 5-fluorouracil in a colon_carcinoma murine model .
18602896	0	CF502	34,39	PI3K	53,57	CF502	PI3K	MESH:C531153	5293	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	The A3 adenosine receptor agonist CF502 inhibits the PI3K , PKB/Akt and NF-kappaB signaling pathway in synoviocytes from rheumatoid_arthritis patients and in adjuvant-induced arthritis rats .
25085205	0	CG100649	0,8	COX-2	18,23	CG100649	COX-2	null	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	CG100649 , a novel COX-2 inhibitor , inhibits colorectal_adenoma_and_carcinoma growth in mouse models .
21773733	0	CG200745	39,47	histone_deacetylase	8,27	CG200745	histone deacetylase	MESH:C572619	9734	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	A novel histone_deacetylase inhibitor , CG200745 , potentiates anticancer effect of docetaxel in prostate_cancer via decreasing Mcl-1 and Bcl-XL .
25589346	4	CGI1746	1138,1145	BTK	1123,1126	CGI1746	BTK	MESH:C555057	12229(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Furthermore , overexpression of BTK in myeloma cells promoted tumor growth in laboratory mice and rendered side population-derived tumors that contained high levels of BTK more sensitive to the selective , second-generation BTK inhibitor , CGI1746 , than side population-derived tumors that harbored low levels of BTK .
26206331	0	CGM097	83,89	HDM2	67,71	CGM097	HDM2	null	4193	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Inhibition of wild-type p53-expressing AML by novel small molecule HDM2 inhibitor , CGM097 .
2476594	0	CGP	0,3	renin	48,53	CGP	renin	null	5972	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	CGP 38 560 : orally active , low-molecular-weight renin inhibitor with high potency and specificity .
10805498	0	CGP-12177	19,28	leptin	50,56	CGP-12177	leptin	MESH:C033394	16846(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	In vivo effects of CGP-12177 on the expression of leptin and uncoupling protein genes in mouse brown and white_adipose_tissues .
9676840	0	CGP-57148	179,188	BCR-ABL	131,138	CGP-57148	BCR-ABL	MESH:C097613	25	Chemical	Gene	inhibitor|appos|START_ENTITY END_ENTITY|nmod|inhibitor	Selective inhibition of cell proliferation and BCR-ABL phosphorylation in acute_lymphoblastic_leukemia cells expressing Mr 190,000 BCR-ABL protein by a tyrosine kinase inhibitor -LRB- CGP-57148 -RRB- .
12054962	1	CGP-60536B	82,92	renin	103,108	CGP-60536B	renin	null	5972	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Stereocontrolled approaches to CGP-60536B , a potent renin inhibitor .
6195533	0	CGP_11305_A	11,22	MAO_A	68,73	CGP 11305 A	MAO A	MESH:C038213	29253(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|inhibitor inhibitor|nmod|END_ENTITY	Effects of CGP_11305_A , a new reversible and selective inhibitor of MAO_A , on biogenic amine levels and metabolism in the rat brain .
6197309	0	CGP_11305_A	36,47	MAO_A	53,58	CGP 11305 A	MAO A	MESH:C038213	29253(Tax:10116)	Chemical	Gene	interaction|nmod|START_ENTITY Reversibility|nmod|interaction Reversibility|nmod|END_ENTITY	Reversibility of the interaction of CGP_11305_A with MAO_A in vivo .
2128510	0	CGP_28014	31,40	COMT	15,19	CGP 28014	COMT	MESH:C067181	24267(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Effects of the COMT inhibitor , CGP_28014 , on plasma homovanillic_acid and O-methylation of exogenous L-dopa in the rat .
2128511	0	CGP_28014	43,52	COMT	28,32	CGP 28014	COMT	MESH:C067181	1312	Chemical	Gene	A|compound|START_ENTITY inhibitor|dobj|A inhibitor|nsubj|Effect Effect|nmod|END_ENTITY	Effect of the new selective COMT inhibitor CGP_28014 A on the formation of 3-O-methyldopa -LRB- 3OMD -RRB- in plasma of healthy subjects .
7831657	0	CGP_39393	44,53	thrombin	7,15	CGP 39393	thrombin	MESH:C060225	2147	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|END_ENTITY	Direct thrombin inhibition with Rec-hirudin CGP_39393 as prophylaxis of thromboembolic_complications after total hip replacement .
8596376	0	CGP_39393	117,126	thrombin	71,79	CGP 39393	thrombin	MESH:C060225	2147	Chemical	Gene	hirudin|appos|START_ENTITY inhibition|nmod|hirudin inhibition|compound|END_ENTITY	Prevention of deep-vein_thrombosis after total hip replacement : direct thrombin inhibition with recombinant hirudin , CGP_39393 .
9372245	0	CGP_41251	0,9	substance_P	126,137	CGP 41251	substance P	MESH:C059539	6863	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|nmod|END_ENTITY	CGP_41251 and tamoxifen selectively inhibit mitogen-activated_protein kinase activation and c-Fos phosphoprotein induction by substance_P in human astrocytoma cells .
9990655	0	CGP_42112A	0,10	angiotensin_II	29,43	CGP 42112A	angiotensin II	MESH:C060894	24179(Tax:10116)	Chemical	Gene	antagonism|compound|START_ENTITY antagonism|nmod|END_ENTITY	CGP_42112A antagonism of the angiotensin_II and angiotensin_II -LRB- 3-7 -RRB- facilitation of recall in rats .
1418958	0	CGP_42112B	176,186	AT2	160,163	CGP 42112B	AT2	MESH:C060894	24182(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	Intracerebroventricular angiotensin_II-induced thirst and sodium_appetite in rat are blocked by the AT1 receptor antagonist , Losartan -LRB- DuP_753 -RRB- , but not by the AT2 antagonist , CGP_42112B .
8205541	0	CGP_48664	0,9	S-adenosylmethionine_decarboxylase	17,51	CGP 48664	S-adenosylmethionine decarboxylase	MESH:C082408	11702(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	CGP_48664 , a new S-adenosylmethionine_decarboxylase inhibitor with broad spectrum antiproliferative and antitumor activity .
9078276	0	CGP_48664	0,9	S-adenosylmethionine_decarboxylase	33,67	CGP 48664	S-adenosylmethionine decarboxylase	MESH:C082408	11702(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	CGP_48664 , a potent and specific S-adenosylmethionine_decarboxylase inhibitor : effects on regulation and stability of the enzyme .
7885826	0	CGP_52608	121,130	nuclear_receptor_RZR_alpha	34,60	CGP 52608	nuclear receptor RZR alpha	MESH:C092451	6095	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Transcriptional activation of the nuclear_receptor_RZR_alpha by the pineal gland hormone melatonin and identification of CGP_52608 as a synthetic ligand .
10815921	0	CGP_57148	30,39	BCL-X	113,118	CGP 57148	BCL-X	MESH:C097613	598	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	The tyrosine kinase inhibitor CGP_57148 -LRB- ST1 571 -RRB- induces apoptosis in BCR-ABL-positive cells by down-regulating BCL-X .
1797334	0	CGRP8-37	53,61	CGRP	35,39	CGRP8-37	CGRP	MESH:C058636	796	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|appos|END_ENTITY	A calcitonin gene-related peptide -LRB- CGRP -RRB- antagonist -LRB- CGRP8-37 -RRB- inhibits microvascular responses induced by CGRP and capsaicin in skin .
17292868	0	CGS-21680	36,45	adenosine_A2A_receptor	4,26	CGS-21680	adenosine A2A receptor	MESH:C061282	25369(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	The adenosine_A2A_receptor agonist , CGS-21680 , blocks excessive rearing , acquisition of wheel running , and increases nucleus accumbens CREB phosphorylation in chronically food-restricted rats .
17643133	0	CGS-26303	24,33	endothelin_converting_enzyme-1	44,74	CGS-26303	endothelin converting enzyme-1	MESH:C089987	1889	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	The peptidase inhibitor CGS-26303 increases endothelin_converting_enzyme-1 expression in endothelial cells through accumulation of big endothelin-1 .
8904737	0	CGS19281A	60,69	phenylethanolamine_N-methyltransferase	10,48	CGS19281A	phenylethanolamine N-methyltransferase	MESH:C062736	24661(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Effect of phenylethanolamine_N-methyltransferase inhibitor , CGS19281A , on the alpha-2-adrenoceptor function in the hypothalamus of rats in comparison with SKF29661 , SKF64139 and yohimbine .
10607113	0	CGS_12066B	41,51	5-HT1B	25,31	CGS 12066B	5-HT1B	MESH:C052561	25075(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY agonist|nummod|END_ENTITY	Effects of the selective 5-HT1B agonist , CGS_12066B , on sleep/waking stages and EEG power spectrum in rats .
2153796	0	CGS_19281A	28,38	phenylethanolamine-N-methyltransferase	56,94	CGS 19281A	phenylethanolamine-N-methyltransferase	MESH:C062736	24661(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|inhibitor inhibitor|nmod|END_ENTITY	Antihypertensive effects of CGS_19281A , an inhibitor of phenylethanolamine-N-methyltransferase .
9541188	0	CGS_20267	10,19	aromatase	31,40	CGS 20267	aromatase	MESH:C067431	25147(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of CGS_20267 on ovarian aromatase and gonadotropin levels in the rat .
1632058	0	CGS_21595	76,85	5-lipoxygenase	89,103	CGS 21595	5-lipoxygenase	MESH:C075704	25290(Tax:10116)	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Toxic_peripheral_neuropathy with demyelination in Sprague-Dawley_rats given CGS_21595 -- a 5-lipoxygenase inhibitor .
11909610	0	CGS_21680	11,20	adenosine_A2A_receptor	34,56	CGS 21680	adenosine A2A receptor	MESH:C061282	25369(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Effects of CGS_21680 , a selective adenosine_A2A_receptor agonist , on allergic_airways_inflammation in the rat .
8832218	0	CGS_21680	43,52	adenosine_A2A_receptor	11,33	CGS 21680	adenosine A2A receptor	MESH:C061282	25369(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Effects of adenosine_A2A_receptor agonist , CGS_21680 , on blood pressure , cardiac index and arterial conductance in anaesthetized rats .
9831898	0	CGS_21680	68,77	adenosine_A2A_receptor	36,58	CGS 21680	adenosine A2A receptor	MESH:C061282	25369(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Haemodynamic effects of a selective adenosine_A2A_receptor agonist , CGS_21680 , in chronic heart_failure in anaesthetized rats .
8891297	0	CGS_21680	91,100	adenosine_A2a_receptor	34,56	CGS 21680	adenosine A2a receptor	MESH:C061282	25369(Tax:10116)	Chemical	Gene	serotonin|nmod|START_ENTITY serotonin|nmod|activation activation|amod|END_ENTITY	Augmented release of serotonin by adenosine_A2a_receptor activation and desensitization by CGS_21680 in the rat nucleus tractus solitarius .
1665286	0	CGS_22745	0,9	5-lipoxygenase	50,64	CGS 22745	5-lipoxygenase	MESH:C073115	240	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	CGS_22745 : a selective orally active inhibitor of 5-lipoxygenase .
9109363	0	CGS_23885	43,52	5-lipoxygenase	63,77	CGS 23885	5-lipoxygenase	MESH:C084468	25290(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Inhibition of LTB4 biosynthesis in situ by CGS_23885 , a potent 5-lipoxygenase inhibitor , correlates with its pleural fluid concentrations in an experimentally induced rat pleurisy model .
17259328	0	CGS_26303	37,46	ECE	55,58	CGS 26303	ECE	MESH:C089987	94204(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Functional neuroprotective effect of CGS_26303 , a dual ECE inhibitor , on ischemic-reperfusion spinal_cord_injury in rats .
17367067	0	CGS_26303	188,197	intercellular_adhesion_molecule-1	85,118	CGS 26303	intercellular adhesion molecule-1	MESH:C089987	100009455(Tax:9986)	Chemical	Gene	circulating|nmod|START_ENTITY circulating|dobj|END_ENTITY	Attenuation of experimental subarachnoid_hemorrhage-induced increases in circulating intercellular_adhesion_molecule-1 and cerebral_vasospasm by the endothelin-converting enzyme inhibitor CGS_26303 .
9495857	0	CGS_30440	44,53	angiotensin-converting_enzyme	75,104	CGS 30440	angiotensin-converting enzyme	null	24310(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|inhibitor inhibitor|nmod|END_ENTITY	Antihypertensive and natriuretic effects of CGS_30440 , a dual inhibitor of angiotensin-converting_enzyme and neutral_endopeptidase 24.11 .
12193123	0	CGS_35066	81,90	endothelin-converting_enzyme	104,132	CGS 35066	endothelin-converting enzyme	MESH:C404932	94204(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effects of benazepril , an angiotensin-converting enzyme inhibitor , combined with CGS_35066 , a selective endothelin-converting_enzyme inhibitor , on arterial blood pressure in normotensive and spontaneously hypertensive rats .
2526568	0	CGS_8515	20,28	5-lipoxygenase	44,58	CGS 8515	5-lipoxygenase	MESH:C055523	25290(Tax:10116)	Chemical	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|inhibitor inhibitor|amod|END_ENTITY	Characterization of CGS_8515 as a selective 5-lipoxygenase -LRB- 5-LO -RRB- inhibitor .
2833314	0	CGS_8515	20,28	5-lipoxygenase	44,58	CGS 8515	5-lipoxygenase	MESH:C055523	25290(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|amod|END_ENTITY	Characterization of CGS_8515 as a selective 5-lipoxygenase inhibitor using in vitro and in vivo models .
6353423	0	CG_4203	100,107	renin	8,13	CG 4203	renin	MESH:C039188	24715(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|release release|compound|END_ENTITY	Role of renin release in the hemodynamic , renal and dipsogenic actions of the prostacyclin analogue CG_4203 in conscious rats .
17699104	11	CH-11	1517,1522	JNK	1470,1473	CH-11	JNK	MESH:C418965	5599	Chemical	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	JNK was activated 10 - to 22-fold by anisomycin + CH-11 in U87 cells .
11437326	0	CH-296	69,75	CD34	33,37	CH-296	CD34	null	947	Chemical	Gene	cells|nmod|START_ENTITY cells|compound|END_ENTITY	Retroviral transduction of human CD34 + cells on fibronectin fragment CH-296 is inhibited by high concentrations of vector containing medium .
9731044	0	CH-296	106,112	interleukin-6	133,146	CH-296	interleukin-6	null	3569	Chemical	Gene	using|dobj|START_ENTITY using|nmod|END_ENTITY	Improved gene transfer into baboon marrow repopulating cells using recombinant human fibronectin fragment CH-296 in combination with interleukin-6 , stem_cell_factor , FLT-3_ligand , and megakaryocyte_growth_and_development_factor .
14993789	0	CH-3S	38,43	C3a	77,80	CH-3S	C3a	CHEBI:50326	718	Chemical	Gene	START_ENTITY|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	The effects of cholesterol-3-sulfate -LRB- CH-3S -RRB- on the phosphorylation of human C3a -LRB- hC3a -RRB- in vitro and on the ability of hC3a to induce vascular permeability in rats .
14993789	0	CH-3S	38,43	hC3a	82,86	CH-3S	hC3a	CHEBI:50326	718	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	The effects of cholesterol-3-sulfate -LRB- CH-3S -RRB- on the phosphorylation of human C3a -LRB- hC3a -RRB- in vitro and on the ability of hC3a to induce vascular permeability in rats .
12924942	0	CH1	40,43	p300	35,39	CH1	p300	null	2033	Chemical	Gene	domain|compound|START_ENTITY domain|amod|END_ENTITY	Three conformational states of the p300 CH1 domain define its functional properties .
23831576	0	CH2	4,7	CBP/p300	18,26	CH2	CBP/p300	CHEBI:29358	1387;2033	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	The CH2 domain of CBP/p300 is a novel zinc finger .
24765095	0	CH2	21,24	FcRn	46,50	CH2	FcRn	CHEBI:29358	2217	Chemical	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of IgG1 CH2 and CH3 Domains with FcRn .
5749753	0	CH4	18,21	CCl4	10,14	CH4	CCl4	CHEBI:16183	101114285	Chemical	Gene	production|compound|START_ENTITY Effect|nmod|production Effect|nmod|END_ENTITY	Effect of CCl4 on CH4 and volatile acid production in continuous cultures of rumen organisms and in a sheep rumen .
22586954	0	CH4	40,43	CO2	21,24	CH4	CO2	CHEBI:16183	717	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	-LSB- Effects of elevated CO2 on forest soil CH4 consumption in Changbai Mountains -RSB- .
20304062	0	CH5036249	38,47	VDR	25,28	CH5036249	VDR	MESH:C552205	486588(Tax:9615)	Chemical	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	A novel nonsecosteroidal VDR agonist -LRB- CH5036249 -RRB- exhibits efficacy in a spontaneous benign_prostatic_hyperplasia beagle model .
23667175	0	CH5126766	74,83	MEK	59,62	CH5126766	MEK	null	5609	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Enhanced inhibition of ERK signaling by a novel allosteric MEK inhibitor , CH5126766 , that suppresses feedback reactivation of RAF activity .
21575866	0	CH5424802	0,9	ALK	23,26	CH5424802	ALK	CHEBI:62268	238	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	CH5424802 , a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant .
17556486	0	CHAPS	38,43	ASB-14	11,17	CHAPS	ASB-14	MESH:C028213	142686	Chemical	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	The use of ASB-14 in combination with CHAPS is the best for solubilization of human brain proteins for two-dimensional gel electrophoresis .
20146458	0	CHCl	62,66	CS2	73,76	CHCl	CS2	null	1443	Chemical	Gene	reaction|nmod|START_ENTITY reaction|nmod|END_ENTITY	Theoretical mechanistic study on the ion-molecule reaction of CHCl - with CS2 .
9233380	0	CHCl3	77,82	CCl4	50,54	CHCl3	CCl4	CHEBI:35255	116637(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of dosing vehicle on the hepatotoxicity of CCl4 and nephrotoxicity of CHCl3 in rats .
16462909	5	CHD	1175,1178	VCAM-1	1154,1160	CHD	VCAM-1	null	7412	Chemical	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	CHD inhibition of VCAM-1 expression was totally blocked by pretreatment with the NO synthesis inhibitor L-NMMA , whereas pretreatment with the NO donor DETA-NO further decreased VCAM-1 level in CHD-treated HUVECs , indicating that VCAM-1 regulation by CHD is mediated through increased NO synthesis by CHD .
10871311	0	CHF2819	43,50	acetylcholinesterase	75,95	CHF2819	acetylcholinesterase	MESH:C410961	83817(Tax:10116)	Chemical	Gene	profile|nmod|START_ENTITY END_ENTITY|nsubj|profile	Biochemical and neurobehavioral profile of CHF2819 , a novel , orally active acetylcholinesterase inhibitor for Alzheimer 's _ disease .
12070526	0	CHF2819	0,7	acetylcholinesterase	44,64	CHF2819	acetylcholinesterase	MESH:C410961	83817(Tax:10116)	Chemical	Gene	START_ENTITY|dep|profile profile|nmod|inhibitor inhibitor|compound|END_ENTITY	CHF2819 : pharmacological profile of a novel acetylcholinesterase inhibitor .
25728271	0	CHF5074	0,7	transthyretin	36,49	CHF5074	transthyretin	MESH:C522246	7276	Chemical	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	CHF5074 -LRB- CSP-1103 -RRB- stabilizes human transthyretin in mice humanized at the transthyretin and retinol-binding protein loci .
26945156	0	CHF6001	29,36	PDE-4	49,54	CHF6001	PDE-4	MESH:C000596339	5141	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Evaluation of the effects of CHF6001 , an inhaled PDE-4 inhibitor , on cardiac repolarization and cardiac_arrhythmias in healthy volunteers .
17255282	0	CHIR-124	0,8	Chk1	38,42	CHIR-124	Chk1	MESH:C518919	1111	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	CHIR-124 , a novel potent inhibitor of Chk1 , potentiates the cytotoxicity of topoisomerase I poisons in vitro and in vivo .
25727520	0	CHIR99021	16,25	GSK3	0,4	CHIR99021	GSK3	MESH:C473711	56637(Tax:10090)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nummod|END_ENTITY	GSK3 inhibitors CHIR99021 and 6-bromoindirubin-3 ' - oxime inhibit microRNA maturation in mouse embryonic stem cells .
26938105	0	CHIR99021	0,9	Klf4	19,23	CHIR99021	Klf4	MESH:C473711	9314	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|Expression Expression|compound|END_ENTITY	CHIR99021 enhances Klf4 Expression through b-Catenin Signaling and miR-7a Regulation in J1 Mouse Embryonic Stem Cells .
22540008	0	CHIR99021	55,64	glycogen_synthase_kinase-3	14,40	CHIR99021	glycogen synthase kinase-3	MESH:C473711	56637(Tax:10090)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Pleiotropy of glycogen_synthase_kinase-3 inhibition by CHIR99021 promotes self-renewal of embryonic stem cells from refractory mouse strains .
19655395	0	CHO	92,95	cathepsin_D	96,107	CHO	cathepsin D	CHEBI:42485	1509	Chemical	Gene	protease|compound|START_ENTITY protease|amod|END_ENTITY	Degradation of an Fc-fusion recombinant protein by host cell proteases : Identification of a CHO cathepsin_D protease .
16937399	0	CHO	98,101	erythropoietin	78,92	CHO	erythropoietin	CHEBI:42485	2056	Chemical	Gene	system|compound|START_ENTITY END_ENTITY|nmod|system	Amino_acid and manganese supplementation modulates the glycosylation state of erythropoietin in a CHO culture system .
15121336	0	CHO	55,58	t-PA	40,44	CHO	t-PA	CHEBI:42485	5327	Chemical	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Strategies for fed-batch cultivation of t-PA producing CHO cells : substitution of glucose and glutamine and rational design of culture medium .
15880742	0	CHPG	103,107	mGlu5R	88,94	CHPG	mGlu5R	null	108071(Tax:10090)	Chemical	Gene	agonist|acl|START_ENTITY agonist|amod|END_ENTITY	Chronic treatment with the mGlu5R antagonist MPEP reduces the functional effects of the mGlu5R agonist CHPG in the striatum of 6-hydroxydopamine-lesioned rats : possible relevance to the effects of mGlu5R blockade in Parkinson 's _ disease .
21145592	0	CHR-2797	45,53	Aminopeptidase	0,14	CHR-2797	Aminopeptidase	MESH:C531970	10404	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Aminopeptidase inhibition by the novel agent CHR-2797 -LRB- tosedostat -RRB- for the therapy of acute_myeloid_leukemia .
18701491	0	CHR-2797	0,8	aminopeptidase	31,45	CHR-2797	aminopeptidase	MESH:C531970	10404	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	CHR-2797 : an antiproliferative aminopeptidase inhibitor that leads to amino_acid deprivation in human leukemic cells .
26175413	0	CHZ868	0,6	JAK2	18,22	CHZ868	JAK2	null	3717	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|compound|END_ENTITY	CHZ868 , a Type II JAK2 Inhibitor , Reverses Type I JAK Inhibitor Persistence and Demonstrates Efficacy in Myeloproliferative Neoplasms .
11853686	0	CI-1011	134,141	ACAT	198,202	CI-1011	ACAT	MESH:C423185	1066	Chemical	Gene	avasimibe|appos|START_ENTITY mediating|nmod|avasimibe mechanisms|acl|mediating mechanisms|dep|cholesterol_acyltransferase cholesterol_acyltransferase|appos|END_ENTITY	Intracellular mechanisms mediating the inhibition of apoB-containing lipoprotein synthesis and secretion in HepG2 cells by avasimibe -LRB- CI-1011 -RRB- , a novel acyl-coenzyme_A : _ cholesterol_acyltransferase -LRB- ACAT -RRB- inhibitor .
12595916	0	CI-1011	46,53	ACAT	20,24	CI-1011	ACAT	MESH:C423185	6646	Chemical	Gene	avasimibe|appos|START_ENTITY avasimibe|amod|END_ENTITY	Pharmacology of the ACAT inhibitor avasimibe -LRB- CI-1011 -RRB- .
9568739	0	CI-1011	20,27	ACAT	4,8	CI-1011	ACAT	MESH:C423185	6646	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	The ACAT inhibitor , CI-1011 is effective in the prevention and regression of aortic_fatty_streak_area in hamsters .
9595473	0	CI-1020	12,19	endothelin-A_receptor	24,45	CI-1020	endothelin-A receptor	MESH:C093321	24326(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Efficacy of CI-1020 , an endothelin-A_receptor antagonist , in hypoxic_pulmonary_hypertension .
11442013	0	CI-1020	69,76	endothelin_A_receptor	81,102	CI-1020	endothelin A receptor	MESH:C093321	450187(Tax:9615)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Studies on coronary_arteriopathy in dogs following administration of CI-1020 , an endothelin_A_receptor antagonist .
12031830	0	CI-1031	87,94	Factor_Xa	56,65	CI-1031	Factor Xa	MESH:C114592	2159	Chemical	Gene	ZK-807834|appos|START_ENTITY ZK-807834|compound|END_ENTITY	Human in vitro pharmacodynamic profile of the selective Factor_Xa inhibitor ZK-807834 -LRB- CI-1031 -RRB- .
11803247	0	CI-1031	81,88	factor_Xa	117,126	CI-1031	factor Xa	MESH:C114592	2159	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Assessment of ex vivo pharmacodynamic markers during inhibition of thrombosis by CI-1031 -LRB- ZK-807834 -RRB- , a novel direct factor_Xa inhibitor .
11899248	0	CI-1031	49,56	factor_Xa	17,26	CI-1031	factor Xa	MESH:C114592	2159	Chemical	Gene	ZK_807834|appos|START_ENTITY inhibitor|appos|ZK_807834 inhibitor|compound|END_ENTITY	Discovery of the factor_Xa inhibitor , ZK_807834 -LRB- CI-1031 -RRB- .
16845180	0	CI-1034	65,72	endothelin_A_receptor	77,98	CI-1034	endothelin A receptor	MESH:C419982	450187(Tax:9615)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Acute coronary_artery_injury in dogs following administration of CI-1034 , an endothelin_A_receptor antagonist .
26415098	0	CI-1040	31,38	ERK	11,14	CI-1040	ERK	MESH:C120227	24338(Tax:10116)	Chemical	Gene	Activation|nmod|START_ENTITY Activation|compound|END_ENTITY	Inhibiting ERK Activation with CI-1040 Leads to Compensatory Upregulation of Alternate MAPKs and Plasminogen_Activator_Inhibitor-1 following Subtotal Nephrectomy with No Impact on Kidney Fibrosis .
14613031	0	CI-1040	0,7	MEK	64,67	CI-1040	MEK	MESH:C120227	5609	Chemical	Gene	PD184352|compound|START_ENTITY PD184352|appos|inhibitor inhibitor|nmod|END_ENTITY	CI-1040 -LRB- PD184352 -RRB- , a targeted signal transduction inhibitor of MEK -LRB- MAPKK -RRB- .
15483017	0	CI-1040	54,61	MEK	39,42	CI-1040	MEK	MESH:C120227	5609	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Multicenter phase II study of the oral MEK inhibitor , CI-1040 , in patients with advanced non-small-cell lung , breast , colon , and pancreatic_cancer .
15497695	0	CI-1040	57,64	MEK	68,71	CI-1040	MEK	MESH:C120227	5609	Chemical	Gene	inhibitor|nmod|START_ENTITY inhibitor|nsubj|END_ENTITY	In vitro and in vivo metabolism of the anti-cancer agent CI-1040 , a MEK inhibitor , in rat , monkey , and human .
15967111	0	CI-1040	64,71	MEK	49,52	CI-1040	MEK	MESH:C120227	17242(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	A role for K-ras in conferring resistance to the MEK inhibitor , CI-1040 .
18952427	0	CI-1040	52,59	MEK	37,40	CI-1040	MEK	MESH:C120227	5609	Chemical	Gene	inhibitors|dobj|START_ENTITY inhibitors|nsubj|discovery discovery|nmod|END_ENTITY	The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD_0325901 .
1685600	0	CI-943	11,17	neurotensin	85,96	CI-943	neurotensin	MESH:C061283	299757(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|concentrations concentrations|compound|END_ENTITY	Effects of CI-943 , a potential antipsychotic drug , and haloperidol on regional brain neurotensin concentrations .
15972316	0	CI-976	61,67	LPAT	43,47	CI-976	LPAT	MESH:C069304	10554	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|appos|END_ENTITY	A unique lysophospholipid_acyltransferase -LRB- LPAT -RRB- antagonist , CI-976 , affects secretory and endocytic membrane trafficking pathways .
15972316	0	CI-976	61,67	lysophospholipid_acyltransferase	9,41	CI-976	lysophospholipid acyltransferase	MESH:C069304	10554	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	A unique lysophospholipid_acyltransferase -LRB- LPAT -RRB- antagonist , CI-976 , affects secretory and endocytic membrane trafficking pathways .
2178014	0	CI-977	0,6	kappa-opioid_receptor	46,67	CI-977	kappa-opioid receptor	MESH:C067110	100135587(Tax:10141)	Chemical	Gene	START_ENTITY|appos|agonist agonist|nmod|END_ENTITY	CI-977 , a novel and selective agonist for the kappa-opioid_receptor .
8701030	0	CI-988	103,109	CCK-B_receptor	77,91	CI-988	CCK-B receptor	MESH:C065599	25706(Tax:10116)	Chemical	Gene	Inhibition|amod|START_ENTITY Inhibition|nmod|response response|nmod|rats rats|nmod|antagonist antagonist|amod|END_ENTITY	Inhibition of pentagastrin-induced pressor response in conscious rats by the CCK-B_receptor antagonist CI-988 and chlordiazepoxide .
8748432	0	CI-988	73,79	CCK-B_receptor	46,60	CI-988	CCK-B receptor	MESH:C065599	887	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	A double-blind , placebo-controlled study of a CCK-B_receptor antagonist , CI-988 , in patients with generalized_anxiety_disorder .
9200280	0	CI-988	52,58	gastrin	23,30	CI-988	gastrin	MESH:C065599	25320(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Evaluation of biologic gastrin activity of compound CI-988 in the isolated , vascularly perfused rat stomach .
8713686	0	CI-988	104,110	gastrin_receptor	75,91	CI-988	gastrin receptor	MESH:C065599	887	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	Dose dependent in vivo inhibition of human colorectal_cancer -LRB- LoVo -RRB- by the gastrin_receptor antagonist , CI-988 .
24415868	0	CIGB-230	41,49	IFN-a	70,75	CIGB-230	IFN-a	null	3440	Chemical	Gene	induced|nmod|START_ENTITY induced|nmod|END_ENTITY	HCV-specific immune responses induced by CIGB-230 in combination with IFN-a plus ribavirin .
18031725	0	CJ-042	46,52	prostanoid_EP4_receptor	10,33	CJ-042	prostanoid EP4 receptor	null	84023(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Effect of prostanoid_EP4_receptor antagonist , CJ-042 ,794 , in rat models of pain and inflammation .
19580807	0	CJ-13610	0,8	5-lipoxygenase	40,54	CJ-13610	5-lipoxygenase	MESH:C496810	25290(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	CJ-13610 , an orally active inhibitor of 5-lipoxygenase is efficacious in preclinical models of pain .
19350469	0	CK-1827452	0,10	myosin	41,47	CK-1827452	myosin	MESH:C547293	79784	Chemical	Gene	START_ENTITY|appos|activator activator|compound|END_ENTITY	CK-1827452 , a sarcomere-directed cardiac myosin activator for acute_and_chronic_heart_disease .
25924427	0	CL264	75,80	TLR7	62,66	CL264	TLR7	null	51284	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- The study of increased immunogenicity of UCMSC Stimulated by TLR7 agonist CL264 -RSB- .
8637456	0	CL316	10,15	beta3-adrenoceptor	39,57	CL316	beta3-adrenoceptor	null	11556(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Effect of CL316 ,243 , a highly specific beta3-adrenoceptor agonist , on sympathetic nervous system activity in mice .
12898466	0	CLX-0921	70,78	PPAR_gamma	49,59	CLX-0921	PPAR gamma	MESH:C477418	5468	Chemical	Gene	agonist|appos|START_ENTITY agonist|appos|END_ENTITY	A novel peroxisome proliferator-activated gamma -LRB- PPAR_gamma -RRB- agonist , CLX-0921 , has potent antihyperglycemic activity with low adipogenic potential .
22189156	0	CL_316243	27,36	beta-3-adrenoceptor	38,57	CL 316243	beta-3-adrenoceptor	MESH:C076126	25645(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|agonist agonist|amod|END_ENTITY	Effects and selectivity of CL_316243 , beta-3-adrenoceptor agonist , in term-pregnant rat myometrium .
26397189	0	CMP-Neu5Ac	75,85	GM3-Synthase	103,115	CMP-Neu5Ac	GM3-Synthase	MESH:C561601	8869	Chemical	Gene	Evaluation|nmod|START_ENTITY Evaluation|nmod|END_ENTITY	Synthesis and Biological Evaluation of Several Dephosphonated Analogues of CMP-Neu5Ac as Inhibitors of GM3-Synthase .
25364620	0	CNB-001	31,38	Tissue_Plasminogen_Activator	42,70	CNB-001	Tissue Plasminogen Activator	MESH:C529348	100128998	Chemical	Gene	START_ENTITY|nmod|Activity Activity|compound|END_ENTITY	Effect of the Pleiotropic Drug CNB-001 on Tissue_Plasminogen_Activator -LRB- tPA -RRB- Protease Activity in vitro : Support for Combination Therapy to Treat Acute Ischemic_Stroke .
18573905	0	CNI-1493	0,8	Abeta	18,23	CNI-1493	Abeta	MESH:C097256	11820(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	CNI-1493 inhibits Abeta production , plaque formation , and cognitive_deterioration in an animal model of Alzheimer 's _ disease .
9933418	0	CNI-1493	87,95	TNF-alpha	65,74	CNI-1493	TNF-alpha	MESH:C097256	24835(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|appos|END_ENTITY	Anti-inflammatory effects of a new tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- inhibitor -LRB- CNI-1493 -RRB- in collagen-induced_arthritis -LRB- CIA -RRB- in rats .
9539777	0	CNI-1493	32,40	interleukin-2	69,82	CNI-1493	interleukin-2	MESH:C097256	116562(Tax:10116)	Chemical	Gene	blocks|nsubj|START_ENTITY blocks|dobj|effects effects|nmod|END_ENTITY	The tetravalent guanylhydrazone CNI-1493 blocks the toxic effects of interleukin-2 without diminishing antitumor efficacy .
14622812	0	CNI-1493	27,35	p38	39,42	CNI-1493	p38	MESH:C097256	1432	Chemical	Gene	administration|nmod|START_ENTITY administration|appos|inhibitor inhibitor|amod|END_ENTITY	Systemic administration of CNI-1493 , a p38 mitogen-activated protein kinase inhibitor , blocks intrathecal human_immunodeficiency_virus-1 gp120-induced enhanced pain states in rats .
8632999	0	CNI-1493	0,8	tumor_necrosis_factor	38,59	CNI-1493	tumor necrosis factor	MESH:C097256	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	CNI-1493 inhibits monocyte/macrophage tumor_necrosis_factor by suppression of translation efficiency .
17975159	0	CNTO	43,47	interleukin-6	14,27	CNTO	interleukin-6	null	3569	Chemical	Gene	signaling|nmod|START_ENTITY signaling|amod|END_ENTITY	Inhibition of interleukin-6 signaling with CNTO 328 enhances the activity of bortezomib in preclinical models of multiple_myeloma .
18849357	0	CNTO736	0,7	glucagon-like_peptide-1_receptor	17,49	CNTO736	glucagon-like peptide-1 receptor	null	14652(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	CNTO736 , a novel glucagon-like_peptide-1_receptor agonist , ameliorates insulin resistance and inhibits very low-density lipoprotein production in high-fat-fed mice .
24666736	0	CNX-011-67	0,10	GPR40	20,25	CNX-011-67	GPR40	null	266607(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	CNX-011-67 , a novel GPR40 agonist , enhances glucose responsiveness , insulin secretion and islet insulin content in n-STZ rats and in islets from type 2 diabetic patients .
25186493	0	CNX-011-67	23,33	GPR40	8,13	CNX-011-67	GPR40	null	2864	Chemical	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	A novel GPR40 agonist , CNX-011-67 , suppresses glucagon secretion in pancreatic islets under chronic glucolipotoxic conditions in vitro .
26877289	0	CO-37	0,5	estrogen_receptor_ALPHA	34,57	CO-37	estrogen receptor ALPHA	null	13982(Tax:10090)	Chemical	Gene	START_ENTITY|dep|Importance Importance|nmod|END_ENTITY	CO-37 : Importance of the membrane estrogen_receptor_ALPHA -LRB- ERA -RRB- in the vascular response to shear stress in mice .
26877299	0	CO-46	0,5	estrogen_receptor_alpha	30,53	CO-46	estrogen receptor alpha	null	13982(Tax:10090)	Chemical	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	CO-46 : Protective role of the estrogen_receptor_alpha during hypertension .
24616552	0	CO-RM2	18,24	HO-1	0,4	CO-RM2	HO-1	MESH:C447082	3162	Chemical	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	HO-1 induction by CO-RM2 attenuates TNF-a-induced cytosolic_phospholipase_A2 expression via inhibition of PKCa-dependent NADPH oxidase/ROS and NF-kB .
3080904	2	CO2	56,59	P50	70,73	CO2	P50	CHEBI:29334	395587(Tax:9031)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of CO2 and pH on P50 in the chicken .
26764376	0	CO2	64,67	SLAC1	39,44	CO2	SLAC1	D002245	837805(Tax:3702)	Chemical	Gene	Signals|compound|START_ENTITY Signals|compound|END_ENTITY	The Transmembrane Region of Guard Cell SLAC1 Channels Perceives CO2 Signals via an ABA-Independent Pathway in Arabidopsis .
17612734	0	CO2_hydrate	52,63	CO2	90,93	CO2 hydrate	CO2	null	717	Chemical	Gene	START_ENTITY|nmod|presence presence|nmod|END_ENTITY	Phase field modeling of CH4_hydrate conversion into CO2_hydrate in the presence of liquid CO2 .
20874812	0	COG	34,37	Golgin-84	15,24	COG	Golgin-84	null	9950	Chemical	Gene	complex|compound|START_ENTITY END_ENTITY|nmod|complex	Interaction of Golgin-84 with the COG complex mediates the intra-Golgi retrograde transport .
15312765	0	COOH	63,67	Csk	89,92	COOH	Csk	CHEBI:46883	1445	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	Dynamic coupling between the SH2 domain and active site of the COOH terminal Src kinase , Csk .
15131020	5	COOH	860,864	UCP1	873,877	COOH	UCP1	CHEBI:46883	22227(Tax:10090)	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	COOH induced UCP1 expression in brown and white adipose tissues as well as that of other genes associated with substrate oxidation and thermogenesis .
3446410	0	COOH	76,80	apolipoprotein_C-III	100,120	COOH	apolipoprotein C-III	CHEBI:46883	408009(Tax:9913)	Chemical	Gene	region|compound|START_ENTITY region|nmod|END_ENTITY	Activation of lipoprotein_lipase by apolipoprotein_C-II is modulated by the COOH terminal region of apolipoprotein_C-III .
23036353	0	COR167	21,27	CB2	8,11	COR167	CB2	MESH:C580859	57302(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	A novel CB2 agonist , COR167 , potently protects rat brain cortical slices against OGD and reperfusion_injury .
24628691	0	CORM-2	13,19	vascular_cell_adhesion_molecule-1	41,74	CORM-2	vascular cell adhesion molecule-1	MESH:C447082	7412	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	The CO donor CORM-2 inhibits LPS-induced vascular_cell_adhesion_molecule-1 expression and leukocyte adhesion in human rheumatoid synovial fibroblasts .
22210380	0	CORM-3	56,62	VCAM-1	14,20	CORM-3	VCAM-1	null	7412	Chemical	Gene	cells|nmod|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	Inhibition of VCAM-1 expression in endothelial cells by CORM-3 : the role of the ubiquitin-proteasome system , p38 , and mitochondrial respiration .
17713353	7	CORT	1051,1055	mice	1082,1086	CORT	CORT	null	12854(Tax:10090)	Chemical	Gene	secretion|amod|START_ENTITY secretion|nmod|END_ENTITY	Also , we analyzed the effects of SD on CORT secretion of Swiss albino mice , which do not present immune alterations .
20298537	0	COU254	0,6	factor_XII	67,77	COU254	factor XII	null	58992(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	COU254 , a specific 3-carboxamide-coumarin inhibitor of coagulation factor_XII , does not protect mice from acute ischemic_stroke .
19011431	0	CP-101	144,150	NR2B	88,92	CP-101	NR2B	null	2904	Chemical	Gene	antagonist|amod|START_ENTITY selective|dep|antagonist design|amod|selective design|acl|establish establish|dobj|proof proof|nmod|concept concept|nmod|effects effects|nmod|subunit subunit|compound|END_ENTITY	An innovative design to establish proof of concept of the antidepressant effects of the NR2B subunit selective N-methyl-D-aspartate antagonist , CP-101 ,606 , in patients with treatment-refractory major depressive_disorder .
8813551	0	CP-122	37,43	NK1	62,65	CP-122	NK1	null	6869	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|antagonist antagonist|compound|END_ENTITY	Broad spectrum antiemetic effects of CP-122 ,721 , a tachykinin NK1 receptor antagonist , in ferrets .
19826045	0	CP-31398	56,64	TP53	68,72	CP-31398	TP53	MESH:C402665	24842(Tax:10116)	Chemical	Gene	START_ENTITY|appos|modulator modulator|compound|END_ENTITY	Inhibition of azoxymethane-induced colorectal_cancer by CP-31398 , a TP53 modulator , alone or in combination with low doses of celecoxib in male F344 rats .
18060030	0	CP-31398	0,8	p53	25,28	CP-31398	p53	MESH:C402665	22060(Tax:10090)	Chemical	Gene	restores|nsubj|START_ENTITY restores|dobj|function function|compound|END_ENTITY	CP-31398 restores mutant p53 tumor suppressor function and inhibits UVB-induced skin_carcinogenesis in mice .
23362976	0	CP-376395	130,139	CRF-R1	111,117	CP-376395	CRF-R1	MESH:C529296	1394	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	Intermittent access ethanol consumption dysregulates CRF function in the hypothalamus and is attenuated by the CRF-R1 antagonist , CP-376395 .
16493073	0	CP-481	35,41	CCR1	19,23	CP-481	CCR1	null	1230	Chemical	Gene	antagonist|amod|START_ENTITY antagonist|compound|END_ENTITY	The human specific CCR1 antagonist CP-481 ,715 inhibits cell infiltration and inflammatory responses in human CCR1 transgenic_mice .
16148442	0	CP-55940	156,164	CB1	12,15	CP-55940	CB1	MESH:C054649	12801(Tax:10090)	Chemical	Gene	antagonism|appos|START_ENTITY effect|nmod|antagonism role|dep|effect role|nmod|receptors receptors|nummod|END_ENTITY	The role of CB1 receptors in sweet versus fat reinforcement : effect of CB1 receptor deletion , CB1 receptor antagonism -LRB- SR141716A -RRB- and CB1 receptor agonism -LRB- CP-55940 -RRB- .
16148442	0	CP-55940	156,164	CB1	71,74	CP-55940	CB1	MESH:C054649	12801(Tax:10090)	Chemical	Gene	antagonism|appos|START_ENTITY antagonism|compound|END_ENTITY	The role of CB1 receptors in sweet versus fat reinforcement : effect of CB1 receptor deletion , CB1 receptor antagonism -LRB- SR141716A -RRB- and CB1 receptor agonism -LRB- CP-55940 -RRB- .
16148442	0	CP-55940	156,164	CB1	94,97	CP-55940	CB1	MESH:C054649	12801(Tax:10090)	Chemical	Gene	antagonism|appos|START_ENTITY antagonism|dep|END_ENTITY	The role of CB1 receptors in sweet versus fat reinforcement : effect of CB1 receptor deletion , CB1 receptor antagonism -LRB- SR141716A -RRB- and CB1 receptor agonism -LRB- CP-55940 -RRB- .
21594972	0	CP-601	95,101	nicotinic_acetylcholine_receptor	46,78	CP-601	nicotinic acetylcholine receptor	null	170945(Tax:10116)	Chemical	Gene	agonist|amod|START_ENTITY agonist|compound|END_ENTITY	Toxicity study in juvenile rats with the a4b2 nicotinic_acetylcholine_receptor partial agonist CP-601 ,927 .
16314797	0	CP-690	32,38	JAK3	11,15	CP-690	JAK3	null	102134669	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|Effects Effects|nmod|END_ENTITY	Effects of JAK3 inhibition with CP-690 ,550 on immune cell populations and their functions in nonhuman primate recipients of kidney allografts .
16378072	0	CP-690	35,41	JAK3	20,24	CP-690	JAK3	null	3718	Chemical	Gene	START_ENTITY|nsubj|use use|nmod|inhibitor inhibitor|compound|END_ENTITY	Combined use of the JAK3 inhibitor CP-690 ,550 with mycophenolate_mofetil to prevent kidney allograft rejection in nonhuman primates .
17081232	0	CP-690	31,37	Janus_kinase_3	0,14	CP-690	Janus kinase 3	null	25326(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Janus_kinase_3 inhibition with CP-690 ,550 prevents allograft vasculopathy .
19431082	0	CP-690550	0,9	JAK3	13,17	CP-690550	JAK3	MESH:C479163	3718	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	CP-690550 , a JAK3 inhibitor as an immunosuppressant for the treatment of rheumatoid_arthritis , transplant rejection , psoriasis and other immune-mediated disorders .
1383634	0	CP-80	96,101	renin	79,84	CP-80	renin	null	100724037	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Synergistic effect on reduction in blood pressure with coadministration of the renin inhibitor , CP-80 ,794 , and the angiotensin converting enzyme inhibitor , captopril .
20190014	0	CP-900691	70,79	peroxisome_proliferator-activated_receptor_alpha	12,60	CP-900691	peroxisome proliferator-activated receptor alpha	MESH:C549915	102133372	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	A selective peroxisome_proliferator-activated_receptor_alpha agonist , CP-900691 , improves plasma lipids , lipoproteins , and glycemic control in diabetic monkeys .
1319017	0	CP-96	166,171	NK-1	150,154	CP-96	NK-1	null	6869	Chemical	Gene	antagonist|amod|START_ENTITY antagonist|compound|END_ENTITY	NK-1 , but not NK-2 , tachykinin receptors mediate plasma extravasation induced by antidromic C-fiber stimulation in rat hindpaw : demonstrated with the NK-1 antagonist CP-96 ,345 and the NK-2 antagonist Men_10207 .
1328962	0	CP-96	111,116	NK-1_receptor	137,150	CP-96	NK-1 receptor	null	24807(Tax:10116)	Chemical	Gene	studies|amod|START_ENTITY studies|nmod|END_ENTITY	Role of NK-1_receptor in central cardiovascular regulation in rats : studies on a novel non-peptide antagonist , CP-96 ,345 , of substance P NK-1_receptor .
7519186	0	CP-96	92,97	NK1_receptor	68,80	CP-96	NK1 receptor	null	24807(Tax:10116)	Chemical	Gene	antagonist|amod|START_ENTITY antagonist|amod|END_ENTITY	Ventilatory responses to hypoxia in rats pretreated with nonpeptide NK1_receptor antagonist CP-96 ,345 .
7663799	0	CP-99	38,43	NK1_receptor	13,25	CP-99	NK1 receptor	null	6869	Chemical	Gene	Effect|appos|START_ENTITY Effect|nmod|antagonist antagonist|amod|END_ENTITY	Effect of an NK1_receptor antagonist -LRB- CP-99 ,994 -RRB- on hypertonic saline-induced bronchoconstriction and cough in male asthmatic subjects .
9368572	0	CP101	10,15	NR2B	29,33	CP101	NR2B	null	2904	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Effect of CP101 ,606 , a novel NR2B subunit antagonist of the N-methyl-D-aspartate receptor , on the volume of ischemic brain_damage off cytotoxic_brain_edema after middle_cerebral_artery_occlusion in the feline brain .
10422655	0	CP122	33,38	fos	61,64	CP122	fos	null	314322(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Differential effects of low dose CP122 ,288 and eletriptan on fos expression due to stimulation of the superior sagittal sinus in cat .
12568918	0	CP8668	0,6	progesterone_receptor	43,64	CP8668	progesterone receptor	MESH:C476228	100009094(Tax:9986)	Chemical	Gene	START_ENTITY|appos|modulator modulator|compound|END_ENTITY	CP8668 , a novel orally active nonsteroidal progesterone_receptor modulator with tetrahydrobenzindolone skeleton .
16403570	0	CPA	74,77	adenosine_A1_receptor	44,65	CPA	adenosine A1 receptor	null	29290(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|agonist agonist|amod|END_ENTITY	The antinociceptive effects of the systemic adenosine_A1_receptor agonist CPA in the absence and in the presence of spinal cord sensitization .
16143012	0	CPB	21,24	interleukin-8	28,41	CPB	interleukin-8	null	3576	Chemical	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	Effects of pulsatile CPB on interleukin-8 and endothelin-1 levels .
12553912	4	CPD	673,676	Sic1	686,690	CPD	Cdc4	null	55294	Chemical	Gene	motif|compound|START_ENTITY motif|nmod|END_ENTITY	The low affinity of each CPD motif in Sic1 reflects structural discordance with one or more elements of the Cdc4 binding site .
11841235	5	CPF	1423,1426	yeast	1417,1422	CPF	Pta1p	null	851255(Tax:4932)	Chemical	Gene	complex|compound|START_ENTITY complex|compound|END_ENTITY	To confirm the interaction of Glc7p with this complex , we used the same approach to purify and characterize the components of the yeast CPF complex using protein A-tagged Pta1p .
17696823	0	CPG-7909	0,8	toll-like_receptor-9	32,52	CPG-7909	toll-like receptor-9	MESH:C483020	54106	Chemical	Gene	START_ENTITY|dep|agonist agonist|amod|END_ENTITY	CPG-7909 -LRB- PF-3512676 , ProMune -RRB- : toll-like_receptor-9 agonist in cancer therapy .
15534490	0	CPG_7909	129,137	TLR9	184,188	CPG 7909	TLR9	MESH:C483020	54106	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Induction of systemic TH1-like innate immunity in normal volunteers following subcutaneous but not intravenous administration of CPG_7909 , a synthetic B-class CpG oligodeoxynucleotide TLR9 agonist .
23792641	0	CPG_7909	55,63	Toll-like_receptor_9	67,87	CPG 7909	Toll-like receptor 9	MESH:C483020	54106	Chemical	Gene	START_ENTITY|dep|agonist agonist|compound|END_ENTITY	Phase 2 trial of erlotinib with or without PF-3512676 -LRB- CPG_7909 , a Toll-like_receptor_9 agonist -RRB- in patients with advanced recurrent EGFR-positive non-small_cell_lung_cancer .
20552970	0	CPI-2081	106,114	cysteine_protease	77,94	CPI-2081	cysteine protease	MESH:C551615	1508	Chemical	Gene	inhibitor|appos|START_ENTITY END_ENTITY|dobj|inhibitor	Isolation , structure , and functional elucidation of a modified pentapeptide , cysteine_protease inhibitor -LRB- CPI-2081 -RRB- from Streptomyces species 2081 that exhibit inhibitory effect on cancer cell migration .
25092564	0	CPT	56,59	TRAIL	81,86	CPT	TRAIL	CHEBI:27656	8743	Chemical	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	A multicenter , open-label phase II study of recombinant CPT -LRB- Circularly Permuted TRAIL -RRB- plus thalidomide in patients with relapsed and refractory multiple_myeloma .
17239528	0	CPT-Ialpha	48,58	carnitine_palmitoyltransferase_I	14,46	CPT-Ialpha	carnitine palmitoyltransferase I	null	1375	Chemical	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Regulation of carnitine_palmitoyltransferase_I -LRB- CPT-Ialpha -RRB- gene expression by the peroxisome proliferator activated receptor gamma coactivator -LRB- PGC-1 -RRB- isoforms .
26870239	0	CPU-XT-008	10,20	fibroblast_growth_factor	148,172	CPU-XT-008	fibroblast growth factor	null	2247	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of CPU-XT-008 , a combretastatin_A-4 analogue , on the proliferation , apoptosis and expression of vascular_endothelial_growth_factor and basic fibroblast_growth_factor in human umbilical vein endothelial cells .
3212779	0	CR-1409	21,28	cholecystokinin	57,72	CR-1409	cholecystokinin	null	25298(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|inhibitor inhibitor|nmod|END_ENTITY	Inhibitory effect of CR-1409 , a competitive inhibitor of cholecystokinin , on pancreatic exocrine secretion in the conscious rat .
1616859	0	CR2093	55,61	gastrin_receptor	26,42	CR2093	gastrin receptor	null	887	Chemical	Gene	effect|appos|START_ENTITY effect|nmod|antagonist antagonist|compound|END_ENTITY	Therapeutic effect of the gastrin_receptor antagonist , CR2093 on gastrointestinal_tumour cell growth .
16891455	0	CRA-026440	0,10	histone_deacetylase	49,68	CRA-026440	histone deacetylase	MESH:C513933	9734	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	CRA-026440 : a potent , broad-spectrum , hydroxamic histone_deacetylase inhibitor with antiproliferative and antiangiogenic activity in vitro and in vivo .
12464367	0	CRA1000	66,73	CRF	38,41	CRA1000	CRF	MESH:C117406	81648(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	Effect of chronic administration of a CRF -LRB- 1 -RRB- receptor antagonist , CRA1000 , on locomotor activity and endocrine responses to stress .
8865316	0	CRC_220	89,96	thrombin	69,77	CRC 220	thrombin	MESH:C093375	2147	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Effects of permeation enhancers on the transport of a peptidomimetic thrombin inhibitor -LRB- CRC_220 -RRB- in a human intestinal cell line -LRB- Caco-2 -RRB- .
2819453	0	CRF-41	26,32	Neuropeptide-Y	0,14	CRF-41	Neuropeptide-Y	MESH:D003346	24604(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Neuropeptide-Y stimulates CRF-41 release from rat hypothalami in vitro .
21873163	0	CRM197	21,27	HB-EGF	53,59	CRM197	HB-EGF	null	1839	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|inhibitor inhibitor|nmod|END_ENTITY	Antitumor effects of CRM197 , a specific inhibitor of HB-EGF , in T-cell_acute_lymphoblastic_leukemia .
22718294	0	CRM197	11,17	HB-EGF	43,49	CRM197	HB-EGF	null	15200(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|inhibitor inhibitor|nmod|END_ENTITY	Effects of CRM197 , a specific inhibitor of HB-EGF , in oral_cancer .
18342306	0	CR_3394	77,84	NR2B	37,41	CR 3394	NR2B	MESH:C510385	24410(Tax:10116)	Chemical	Gene	antagonist|dobj|START_ENTITY antagonist|nsubj|effects effects|nmod|receptor receptor|compound|END_ENTITY	In vivo neurochemical effects of the NR2B selective NMDA receptor antagonist CR_3394 in 6-hydroxydopamine lesioned rats .
22465063	0	CS-0777	27,34	sphingosine_1-phosphate_receptor-1	48,82	CS-0777	sphingosine 1-phosphate receptor-1	MESH:C569297	1901	Chemical	Gene	START_ENTITY|appos|modulator modulator|amod|END_ENTITY	Pharmacological effects of CS-0777 , a selective sphingosine_1-phosphate_receptor-1 modulator : results from a 12-week , open-label pilot study in multiple_sclerosis patients .
21613209	0	CS-0777	57,64	sphingosine_1-phosphate_receptor_1	78,112	CS-0777	sphingosine 1-phosphate receptor 1	MESH:C569297	1901	Chemical	Gene	START_ENTITY|appos|modulator modulator|amod|END_ENTITY	Purification and identification of activating enzymes of CS-0777 , a selective sphingosine_1-phosphate_receptor_1 modulator , in erythrocytes .
16626720	0	CS-505	34,40	ACAT	0,4	CS-505	ACAT	MESH:C509302	223920(Tax:10090)	Chemical	Gene	sulfate|appos|START_ENTITY sulfate|compound|END_ENTITY	ACAT inhibitor pactimibe sulfate -LRB- CS-505 -RRB- reduces and stabilizes atherosclerotic_lesions by cholesterol-lowering and direct effects in apolipoprotein_E-deficient mice .
3092836	0	CS-514	14,20	HMG-CoA_reductase	38,55	CS-514	HMG-CoA reductase	MESH:D017035	3156	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|inhibitor inhibitor|nmod|END_ENTITY	The effect of CS-514 , an inhibitor of HMG-CoA_reductase , on serum lipids in healthy volunteers .
10894553	0	CS-518	42,48	thromboxane_synthase	10,30	CS-518	thromboxane synthase	MESH:C055806	100719442	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Effect of thromboxane_synthase inhibitor , CS-518 , on propranolol-induced bronchoconstriction in guinea_pigs .
8223890	0	CS-518	11,17	thromboxane_synthase	21,41	CS-518	thromboxane synthase	MESH:C055806	100719442	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effects of CS-518 , a thromboxane_synthase inhibitor , on eosinophil function .
8319745	0	CS-518	11,17	thromboxane_synthase	21,41	CS-518	thromboxane synthase	MESH:C055806	100719442	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effects of CS-518 , a thromboxane_synthase inhibitor , on the asthmatic response .
8427943	0	CS-622	110,116	angiotensin_converting_enzyme	57,86	CS-622	angiotensin converting enzyme	MESH:C055603	1636	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Study on pharmacokinetics of a new biliary excreted oral angiotensin_converting_enzyme inhibitor , temocapril -LRB- CS-622 -RRB- in humans .
17575102	0	CS-706	22,28	cyclooxygenase-2	41,57	CS-706	cyclooxygenase-2	MESH:C514354	19225(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Therapeutic effect of CS-706 , a specific cyclooxygenase-2 inhibitor , on gallbladder_carcinoma in BK5.ErbB-2 mice .
17920584	0	CS-706	36,42	cyclooxygenase-2	52,68	CS-706	cyclooxygenase-2	MESH:C514354	29527(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Preclinical pharmacology profile of CS-706 , a novel cyclooxygenase-2 selective inhibitor , with potent antinociceptive and anti-inflammatory effects .
18027868	0	CS-706	0,6	cyclooxygenase-2	16,32	CS-706	cyclooxygenase-2	MESH:C514354	19225(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	CS-706 , a novel cyclooxygenase-2 selective inhibitor , prolonged the survival of tumor-bearing mice when treated alone or in combination with anti-tumor chemotherapeutic agents .
11787997	0	CS-866	43,49	Angiotensin_II_type-1_receptor	0,30	CS-866	Angiotensin II type-1 receptor	MESH:C097933	100009164(Tax:9986)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Angiotensin_II_type-1_receptor antagonist , CS-866 , reduces blood pressure without affecting glucose/insulin metabolism in cholesterol-fed rabbits .
8566137	0	CS-866	16,22	angiotensin_II	43,57	CS-866	angiotensin II	MESH:C097933	24179(Tax:10116)	Chemical	Gene	nonpeptide|nmod|START_ENTITY nonpeptide|dobj|antagonist antagonist|amod|END_ENTITY	Pharmacology of CS-866 , a novel nonpeptide angiotensin_II receptor antagonist .
9488244	0	CS-866	56,62	angiotensin_II	72,86	CS-866	angiotensin II	MESH:C097933	183	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Blood pressure and endocrine effects of single doses of CS-866 , a novel angiotensin_II antagonist , in salt-restricted hypertensive patients .
11125319	0	CS-891	15,21	5alpha-reductase	31,47	CS-891	5alpha-reductase	MESH:C477151	6715	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	The novel drug CS-891 inhibits 5alpha-reductase activity in freshly isolated dermal papilla of human hair follicles .
14620930	0	CS866	61,66	angiotensin_II_type_1_receptor	18,48	CS866	angiotensin II type 1 receptor	MESH:C097933	81638(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	A newly developed angiotensin_II_type_1_receptor antagonist , CS866 , promotes regression of cardiac_hypertrophy by reducing integrin_beta1 expression .
12124172	0	CT53518	0,7	FLT3	27,31	CT53518	FLT3	MESH:C464670	14255(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	CT53518 , a novel selective FLT3 antagonist for the treatment of acute_myelogenous_leukemia -LRB- AML -RRB- .
22899868	0	CTA056	29,35	interleukin-2-inducible_T-cell_kinase	45,82	CTA056	interleukin-2-inducible T-cell kinase	MESH:C578202	3702	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Molecular characteristics of CTA056 , a novel interleukin-2-inducible_T-cell_kinase inhibitor that selectively targets malignant T cells and modulates oncomirs .
12636163	0	CTAB	14,18	PLG	45,48	CTAB	PLG	MESH:C004322	5340	Chemical	Gene	concentration|amod|START_ENTITY concentration|nmod|END_ENTITY	The effect of CTAB concentration in cationic PLG microparticles on DNA adsorption and in vivo performance .
19588526	0	CTCE-9908	28,37	CXCR4	11,16	CTCE-9908	CXCR4	MESH:C540323	7852	Chemical	Gene	antagonist|dobj|START_ENTITY antagonist|nsubj|Effects Effects|nmod|END_ENTITY	Effects of CXCR4 antagonist CTCE-9908 on prostate_tumor growth .
15466932	0	CTLA-4-Fc	78,87	CD4	97,100	CTLA-4-Fc	CD4	null	920	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Regulation of indoleamine 2,3-dioxygenase and tryptophanyl-tRNA-synthetase by CTLA-4-Fc in human CD4 + T cells .
8181450	0	CTP	59,62	Epidermal_growth_factor	0,23	CTP	Epidermal growth factor	MESH:D003570	25313(Tax:10116)	Chemical	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	Epidermal_growth_factor is a positive in vivo regulator of CTP : cholinephosphate cytidylyltransferase .
11279002	0	CTP	86,89	transcriptional_enhancer_factor-4	18,51	CTP	transcriptional enhancer factor-4	MESH:D003570	21677(Tax:10090)	Chemical	Gene	modulator|nmod|START_ENTITY END_ENTITY|nmod|modulator	Identification of transcriptional_enhancer_factor-4 as a transcriptional modulator of CTP : phosphocholine_cytidylyltransferase_alpha .
26957440	0	CUDC-101	0,8	Androgen_Receptor	43,60	CUDC-101	Androgen Receptor	MESH:C549566	367	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|nmod|END_ENTITY	CUDC-101 , a Novel Inhibitor of Full-Length Androgen_Receptor -LRB- flAR -RRB- and Androgen_Receptor Variant 7 -LRB- AR-V7 -RRB- Activity : Mechanism of Action and In Vivo Efficacy .
25450670	0	CUDC-101	77,85	epidermal_growth_factor_receptor	136,168	CUDC-101	epidermal growth factor receptor	MESH:C549566	1956	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|epidermal_growth_factor_receptor_2 epidermal_growth_factor_receptor_2|compound|END_ENTITY	Human ATP-Binding Cassette transporters ABCB1 and ABCG2 confer resistance to CUDC-101 , a multi-acting inhibitor of histone_deacetylase , epidermal_growth_factor_receptor and human epidermal_growth_factor_receptor_2 .
25450670	0	CUDC-101	77,85	epidermal_growth_factor_receptor_2	179,213	CUDC-101	epidermal growth factor receptor 2	MESH:C549566	2064	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Human ATP-Binding Cassette transporters ABCB1 and ABCG2 confer resistance to CUDC-101 , a multi-acting inhibitor of histone_deacetylase , epidermal_growth_factor_receptor and human epidermal_growth_factor_receptor_2 .
19509149	0	CUDC-305	0,8	HSP90	28,33	CUDC-305	HSP90	MESH:C543177	3320	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	CUDC-305 , a novel synthetic HSP90 inhibitor with unique pharmacologic properties for cancer therapy .
26796063	0	CUDC-907	67,75	histone_deacetylase	97,116	CUDC-907	histone deacetylase	MESH:C576940	9734	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Human ATP-Binding Cassette transporter ABCG2 confers resistance to CUDC-907 , a dual inhibitor of histone_deacetylase and phosphatidylinositol_3-kinase .
16545368	0	CV-11974	0,8	angiotensin_II	10,24	CV-11974	angiotensin II	MESH:C081643	24179(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	CV-11974 , angiotensin_II type I receptor antagonist , protects against ischemia-reperfusion injury of the small intestine in rats .
7511744	0	CV-11974	50,58	angiotensin_II	14,28	CV-11974	angiotensin II	MESH:C081643	24179(Tax:10116)	Chemical	Gene	Effects|amod|START_ENTITY Effects|nmod|receptor receptor|amod|END_ENTITY	Effects of an angiotensin_II receptor antagonist , CV-11974 , on angiotensin_II-induced increases in cytosolic free calcium concentration , hyperplasia , and hypertrophy of cultured vascular smooth muscle cells .
8508911	0	CV-11974	60,68	angiotensin_II	24,38	CV-11974	angiotensin II	MESH:C081643	24179(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Effects of a nonpeptide angiotensin_II receptor antagonist -LRB- CV-11974 -RRB- on -LSB- Ca2 + -RSB- i and cell motion in cultured ventricular myocytes .
7923892	0	CV-11974	84,92	angiotensin_II_type-1_receptor	41,71	CV-11974	angiotensin II type-1 receptor	MESH:C081643	81638(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	The effects of central administration of angiotensin_II_type-1_receptor antagonist , CV-11974 , in nephrectomized spontaneously hypertensive rats .
12434200	0	CV-11974	68,76	angiotensin_II_type_1_receptor	25,55	CV-11974	angiotensin II type 1 receptor	MESH:C081643	100009164(Tax:9986)	Chemical	Gene	treatment|appos|START_ENTITY treatment|nmod|antagonist antagonist|amod|END_ENTITY	Long-term treatment with angiotensin_II_type_1_receptor antagonist , CV-11974 , restores beta-catenin mRNA expression in volume-overloaded rabbit hearts .
1584324	0	CV-6209	54,61	platelet-activating_factor	15,41	CV-6209	platelet-activating factor	MESH:C053321	300795(Tax:10116)	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|amod|END_ENTITY	Effects of the platelet-activating_factor antagonists CV-6209 and CV-3988 on nephrotoxic serum nephritis in the rat .
3612533	0	CV-6209	0,7	platelet_activating_factor	39,65	CV-6209	platelet activating factor	MESH:C053321	9768	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|nmod|END_ENTITY	CV-6209 , a highly potent antagonist of platelet_activating_factor in vitro and in vivo .
11061613	0	CV6504	50,56	5-lipoxygenase	24,38	CV6504	5-lipoxygenase	MESH:C067513	240	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	A phase II study of the 5-lipoxygenase inhibitor , CV6504 , in advanced pancreatic_cancer : correlation of clinical data with pharmacokinetic and pharmacodynamic endpoints .
9057074	0	CVS-1123	0,8	thrombin	19,27	CVS-1123	thrombin	MESH:C101948	2147	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	CVS-1123 , a direct thrombin inhibitor , prevents occlusive arterial and venous_thrombosis in a canine model of vascular_injury .
9360999	0	CVT-313	0,7	CDK2	44,48	CVT-313	CDK2	MESH:C109140	1017	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	CVT-313 , a specific and potent inhibitor of CDK2 that prevents neointimal proliferation .
16010093	0	CYFRA	108,113	SCC	129,132	CYFRA	SCC	null	6317	Chemical	Gene	levels|compound|START_ENTITY levels|nmod|END_ENTITY	The significance of ferritin , lipid-associated sialic_acid , CEA , squamous_cell_carcinoma -LRB- SCC -RRB- antigen , and CYFRA 21-1 levels in SCC of the head_and_neck .
23459451	0	CYT387	23,29	JAK1	33,37	CYT387	JAK1	MESH:C546012	3716	Chemical	Gene	Safety|nmod|START_ENTITY Safety|appos|inhibitor inhibitor|compound|END_ENTITY	Safety and efficacy of CYT387 , a JAK1 and JAK2 inhibitor , in myelofibrosis .
23827160	0	CYT387	131,137	JAK1/2	113,119	CYT387	JAK1/2	MESH:C546012	16451;16452	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	P-glycoprotein -LRB- MDR1/ABCB1 -RRB- and breast_cancer resistance protein -LRB- BCRP/ABCG2 -RRB- restrict brain accumulation of the JAK1/2 inhibitor , CYT387 .
20385788	0	CYT387	0,6	JAK2	16,20	CYT387	JAK2	MESH:C546012	16452(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	CYT387 , a novel JAK2 inhibitor , induces hematologic responses and normalizes inflammatory cytokines in murine myeloproliferative_neoplasms .
21414958	0	Ca	78,80	AtCNGC11	37,45	Ca	AtCNGC11	null	819252(Tax:3702)	Chemical	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	The cyclic nucleotide-gated channels AtCNGC11 and 12 are involved in multiple Ca - dependent physiological responses and act in a synergistic manner .
24292328	6	Ca	946,948	BI-1	931,935	Ca	BI-1	null	110213(Tax:10090)	Chemical	Gene	release|amod|START_ENTITY regulates|dobj|release regulates|nsubj|END_ENTITY	The in vitro study showed that BI-1 regulates Ca release and related MAO-A activity .
2430236	0	Ca	49,51	CA1	76,79	Ca	CA1	null	100720116	Chemical	Gene	currents|amod|START_ENTITY currents|nmod|END_ENTITY	Interaction of 1,4-dihydropyridines with somatic Ca currents in hippocampal CA1 neurones of the guinea_pig in vitro .
12108549	5	Ca-074Me	813,821	cathepsin_B	776,787	Ca-074Me	cathepsin L	MESH:C400541	13039(Tax:10090)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Synthetic inhibitors of cysteine proteinases markedly impaired invasion : cathepsin_B inhibitors , particularly Ca-074Me , inhibited invasion from 20-40 % , whereas cathepsin_L inhibitor Clik_148 reduced invasion by 11 % .
6426500	0	Ca-EDTA	124,131	ALA-D	79,84	Ca-EDTA	ALA-D	null	210	Chemical	Gene	infusion|nmod|START_ENTITY END_ENTITY|nmod|infusion	Lead and zinc concentrations in plasma , erythrocytes , and urine in relation to ALA-D activity after intravenous infusion of Ca-EDTA .
24123252	0	CaIMP	60,65	myo-inositol_monophosphatase	25,53	CaIMP	myo-inositol monophosphatase	null	101496687	Chemical	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Differentially expressed myo-inositol_monophosphatase gene -LRB- CaIMP -RRB- in chickpea -LRB- Cicer_arietinum_L . -RRB-
3922048	0	CaNa2EDTA	38,47	phospholipase_A2	51,67	CaNa2EDTA	phospholipase A2	null	151056	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	A randomized double-blind study using CaNa2EDTA , a phospholipase_A2 inhibitor , in the management of human acute pancreatitis .
25230324	0	Cabergoline	30,41	Prolactin	6,15	Cabergoline	Prolactin	MESH:C047047	5617	Chemical	Gene	Treatment|compound|START_ENTITY Associated|nmod|Treatment Associated|nsubj|Levels Levels|compound|END_ENTITY	Lower Prolactin Levels During Cabergoline Treatment are Associated to Tumor Shrinkage in Prolactin Secreting Pituitary_Adenoma .
25230324	0	Cabergoline	30,41	Prolactin	89,98	Cabergoline	Prolactin	MESH:C047047	5617	Chemical	Gene	Treatment|compound|START_ENTITY Associated|nmod|Treatment Associated|nmod|Shrinkage Shrinkage|nmod|Pituitary_Adenoma Pituitary_Adenoma|compound|END_ENTITY	Lower Prolactin Levels During Cabergoline Treatment are Associated to Tumor Shrinkage in Prolactin Secreting Pituitary_Adenoma .
24914776	0	Cabergoline	0,11	dopamine_D2_receptor	13,33	Cabergoline	dopamine D2 receptor	MESH:C047047	1813	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Cabergoline , dopamine_D2_receptor agonist , prevents neuronal cell death under oxidative stress via reducing excitotoxicity .
15638294	0	Cabergoline	0,11	growth_hormone	40,54	Cabergoline	growth hormone	MESH:C047047	2688	Chemical	Gene	therapy|amod|START_ENTITY therapy|nmod|END_ENTITY	Cabergoline therapy of growth_hormone _ growth_hormone / prolactin secreting pituitary_tumors .
26255947	0	Cabozantinib	0,12	c-Met	22,27	Cabozantinib	c-Met	MESH:C558660	17295(Tax:10090)	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|amod|END_ENTITY	Cabozantinib , a Novel c-Met Inhibitor , Inhibits Colorectal_Cancer Development in a Xenograft Model .
26338447	0	Cabozantinib	0,12	c-Met	195,200	Cabozantinib	c-Met	MESH:C558660	4233	Chemical	Gene	Mediated|nsubj|START_ENTITY Mediated|nmod|Inhibition Inhibition|amod|END_ENTITY	Cabozantinib and Tivantinib , but not INC280 , Induce Anti-Proliferative and Anti-Migratory Effects in Human Neuroendocrine_Tumour Cells in vitro : Evidence for ` Off-Target ' Effects not Mediated by c-Met Inhibition .
24449419	0	Cadmium	0,7	Akt	66,69	Cadmium	Akt	MESH:D002104	11651(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|compound|END_ENTITY	Cadmium selectively induces MIP-2 and COX-2 through PTEN-mediated Akt activation in RAW264 .7 cells .
10771129	0	Cadmium	0,7	Bcl-2	60,65	Cadmium	Bcl-2	MESH:D002104	24224(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Cadmium induces caspase-mediated cell death : suppression by Bcl-2 .
1764062	0	Cadmium	0,7	Cd2	9,12	Cadmium	Cd2	MESH:D002104	396662(Tax:9823)	Chemical	Gene	START_ENTITY|appos|+ +|compound|END_ENTITY	Cadmium -LRB- Cd2 + -RRB- disrupts Ca -LRB- 2 + -RRB- - dependent cell-cell junctions and alters the pattern of E-cadherin immunofluorescence in LLC-PK1 cells .
19413654	1	Cadmium	90,97	Cd2	99,102	Cadmium	Ca2	MESH:D002104	760	Chemical	Gene	START_ENTITY|appos|+ +|compound|END_ENTITY	Cadmium -LRB- Cd2 + -RRB- is an industrial and environmental metal .
1987663	0	Cadmium	0,7	Cd2	9,12	Cadmium	Cd2	MESH:D002104	396662(Tax:9823)	Chemical	Gene	START_ENTITY|appos|+ +|compound|END_ENTITY	Cadmium -LRB- Cd2 + -RRB- disrupts intercellular junctions and actin filaments in LLC-PK1 cells .
9282312	0	Cadmium	0,7	Cd2	9,12	Cadmium	Cd2	MESH:D002104	607448(Tax:9615)	Chemical	Gene	START_ENTITY|appos|+ +|compound|END_ENTITY	Cadmium -LRB- Cd2 + -RRB- disrupts E-cadherin-dependent cell-cell junctions in MDCK cells .
25744307	0	Cadmium	0,7	EGFR	81,85	Cadmium	EGFR	MESH:D002104	1956	Chemical	Gene	activates|nsubj|START_ENTITY activates|dep|MAPKs MAPKs|dep|signaling signaling|nmod|END_ENTITY	Cadmium at nanomolar concentrations activates Raf-MEK-ERK1 / 2 MAPKs signaling via EGFR in human cancer cell lines .
26514923	0	Cadmium	0,7	EGFR	72,76	Cadmium	EGFR	MESH:D002104	13649(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Cadmium induces matrix_metalloproteinase-9 expression via ROS-dependent EGFR , NF - B , and AP-1 pathways in human endothelial cells .
12729619	0	Cadmium	0,7	GLUT4	69,74	Cadmium	GLUT4	MESH:D002104	25139(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|expression expression|compound|END_ENTITY	Cadmium induces impaired_glucose_tolerance in rat by down-regulating GLUT4 expression in adipocytes .
16759985	0	Cadmium	0,7	Grp78	34,39	Cadmium	Grp78	MESH:D002104	407060(Tax:9823)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Cadmium induces the expression of Grp78 , an endoplasmic reticulum molecular chaperone , in LLC-PK1 renal epithelial cells .
23376331	0	Cadmium	0,7	H-ras	18,23	Cadmium	H-ras	MESH:D002104	3265	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|compound|END_ENTITY	Cadmium modulates H-ras expression and caspase-3 apoptotic cell death in breast_cancer epithelial MCF-7 cells .
21984483	0	Cadmium	0,7	HIF-1	18,23	Cadmium	HIF-1	MESH:D002104	3091	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Cadmium increases HIF-1 and VEGF expression through ROS , ERK , and AKT signaling pathways and induces malignant transformation of human bronchial epithelial cells .
15240131	0	Cadmium	0,7	ICAM-1	37,43	Cadmium	ICAM-1	MESH:D002104	15894(Tax:10090)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|nmod|END_ENTITY	Cadmium stimulates the expression of ICAM-1 via NF-kappaB activation in cerebrovascular endothelial cells .
8013439	0	Cadmium	0,7	IL-6	17,21	Cadmium	IL-6	MESH:D002104	3569	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	Cadmium inhibits IL-6 production and IL-6 mRNA expression in a human monocytic cell line , THP-1 .
24449419	0	Cadmium	0,7	MIP-2	28,33	Cadmium	MIP-2	MESH:D002104	20310(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Cadmium selectively induces MIP-2 and COX-2 through PTEN-mediated Akt activation in RAW264 .7 cells .
18573614	0	Cadmium	0,7	MKP-1	29,34	Cadmium	MKP-1	MESH:D002104	114856(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Cadmium specifically induces MKP-1 expression via the glutathione depletion-mediated p38 MAPK activation in C6 glioma cells .
20116811	0	Cadmium	0,7	MPK3	30,34	Cadmium	MPK3	MESH:D002104	823706(Tax:3702)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Cadmium activates Arabidopsis MPK3 and MPK6 via accumulation of reactive oxygen species .
26130599	0	Cadmium	39,46	MSH6	65,69	Cadmium	MSH6	MESH:D002104	260437(Tax:7955)	Chemical	Gene	START_ENTITY|nmod|MutS_Homolog_6 MutS_Homolog_6|appos|END_ENTITY	Comparative Effects of Mercury -LRB- II -RRB- and Cadmium on MutS_Homolog_6 -LRB- MSH6 -RRB- - Mediated DNA Mismatch Binding Activities in Zebrafish -LRB- Danio_rerio -RRB- Embryos .
12662899	0	Cadmium	0,7	Nramp_2	27,34	Cadmium	Nramp 2	MESH:D002104	4891	Chemical	Gene	transport|amod|START_ENTITY transport|nmod|END_ENTITY	Cadmium transport by human Nramp_2 expressed in Xenopus_laevis oocytes .
15760895	0	Cadmium	0,7	OGG1	29,33	Cadmium	OGG1	MESH:D002104	4968	Chemical	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|END_ENTITY	Cadmium down-regulates human OGG1 through suppression of Sp1 activity .
20060848	0	Cadmium	0,7	SGLT1	55,60	Cadmium	SGLT1	MESH:D002104	20537(Tax:10090)	Chemical	Gene	down-regulation|amod|START_ENTITY down-regulation|nmod|Sp1 Sp1|amod|binding binding|nmod|END_ENTITY	Cadmium down-regulation of kidney Sp1 binding to mouse SGLT1 and SGLT2 gene promoters : possible reaction of cadmium with the zinc finger domain of Sp1 .
9512726	0	Cadmium	0,7	SGLT1	18,23	Cadmium	SGLT1	MESH:D002104	20537(Tax:10090)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|RNA RNA|compound|END_ENTITY	Cadmium decreases SGLT1 messenger RNA in mouse kidney cells .
20060848	0	Cadmium	0,7	Sp1	34,37	Cadmium	Sp1	MESH:D002104	20683(Tax:10090)	Chemical	Gene	down-regulation|amod|START_ENTITY down-regulation|nmod|END_ENTITY	Cadmium down-regulation of kidney Sp1 binding to mouse SGLT1 and SGLT2 gene promoters : possible reaction of cadmium with the zinc finger domain of Sp1 .
9850567	0	Cadmium	0,7	TRH	63,66	Cadmium	TRH	MESH:D002104	25569(Tax:10116)	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|nmod|END_ENTITY	Cadmium does not inhibit pulsatile prolactin secretion through TRH .
27060662	0	Cadmium	0,7	UGT1A1	77,83	Cadmium	UGT1A1	MESH:D002104	394436(Tax:10090)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|gene gene|compound|END_ENTITY	Cadmium and arsenic_override NFkB developmental regulation of the intestinal UGT1A1 gene and control of hyperbilirubinemia .
19609071	0	Cadmium	0,7	VCAM-1	72,78	Cadmium	VCAM-1	MESH:D002104	22329(Tax:10090)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|nmod|END_ENTITY	Cadmium stimulates the expression of vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- via p38 mitogen-activated protein kinase -LRB- MAPK -RRB- and JNK activation in cerebrovascular endothelial cells .
26343694	0	Cadmium	9,16	VEGF	29,33	Cadmium	VEGF	MESH:D002104	7422	Chemical	Gene	Upregulates|nsubj|START_ENTITY Upregulates|dobj|Expression Expression|compound|END_ENTITY	Low-Dose Cadmium Upregulates VEGF Expression in Lung_Adenocarcinoma Cells .
20618956	0	Cadmium	0,7	XIAP	37,41	Cadmium	XIAP	MESH:D002104	331	Chemical	Gene	START_ENTITY|dobj|expression expression|nmod|END_ENTITY	Cadmium down-regulates expression of XIAP at the post-transcriptional level in prostate_cancer cells through an NF-kappaB-independent , proteasome-mediated mechanism .
6083804	0	Cadmium	0,7	alpha_2-macroglobulin	25,46	Cadmium	alpha 2-macroglobulin	MESH:D002104	2	Chemical	Gene	START_ENTITY|xcomp|binding binding|nmod|END_ENTITY	Cadmium binding to human alpha_2-macroglobulin .
21219922	0	Cadmium	0,7	c-Fos	53,58	Cadmium	c-Fos	MESH:D002104	2353	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|cells cells|amod|END_ENTITY	Cadmium induces phosphorylation and stabilization of c-Fos in HK-2 renal proximal tubular cells .
26751215	0	Cadmium	0,7	c-Myc	98,103	Cadmium	c-Myc	MESH:D002104	4609	Chemical	Gene	Signaling|compound|START_ENTITY Pathways|nsubj|Signaling Pathways|xcomp|Enhance Enhance|dobj|Stability Stability|amod|END_ENTITY	Cadmium Activates Multiple Signaling Pathways That Coordinately Stimulate Akt Activity to Enhance c-Myc mRNA Stability .
9650640	0	Cadmium	0,7	c-fos	30,35	Cadmium	c-fos	MESH:D002104	2353	Chemical	Gene	START_ENTITY|dobj|expression expression|amod|END_ENTITY	Cadmium and calcium-dependent c-fos expression in mesangial cells .
10799339	0	Cadmium	0,7	c-myc	16,21	Cadmium	c-myc	MESH:D002104	4609	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Cadmium induces c-myc , p53 , and c-jun expression in normal human prostate epithelial cells as a prelude to apoptosis .
17136310	0	Cadmium	0,7	c-myc	82,87	Cadmium	c-myc	MESH:D002104	24577(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|translocation translocation|nmod|expression expression|nmod|END_ENTITY	Cadmium induces nuclear translocation of beta-catenin and increases expression of c-myc and Abcb1a in kidney proximal tubule cells .
11090055	0	Cadmium	0,7	erythropoietin	36,50	Cadmium	erythropoietin	MESH:D002104	2056	Chemical	Gene	suppression|compound|START_ENTITY suppression|nmod|production production|compound|END_ENTITY	Cadmium and platinum suppression of erythropoietin production in cell culture : clinical implications .
20090884	0	Cadmium	0,7	ferroportin-1	18,31	Cadmium	ferroportin-1	MESH:D002104	53945(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Cadmium increases ferroportin-1 gene expression in J774 macrophage cells via the production of reactive oxygen species .
23463649	0	Cadmium	0,7	focal_adhesion_kinase	16,37	Cadmium	focal adhesion kinase	MESH:D002104	14083(Tax:10090)	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|END_ENTITY	Cadmium affects focal_adhesion_kinase -LRB- FAK -RRB- in mesangial cells : involvement of CaMK-II and the actin cytoskeleton .
11884233	0	Cadmium	0,7	intercellular_adhesion_molecule-1	29,62	Cadmium	intercellular adhesion molecule-1	MESH:D002104	15894(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Cadmium - and mercury-induced intercellular_adhesion_molecule-1 expression in immortalized proximal tubule cells : evidence for a role of decreased transforming_growth_factor-beta1 .
26514923	0	Cadmium	0,7	matrix_metalloproteinase-9	16,42	Cadmium	matrix metalloproteinase-9	MESH:D002104	4318	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Cadmium induces matrix_metalloproteinase-9 expression via ROS-dependent EGFR , NF - B , and AP-1 pathways in human endothelial cells .
17961543	0	Cadmium	0,7	p38_MAPK	45,53	Cadmium	p38 MAPK	MESH:D002104	26416(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Cadmium induces apoptotic cell death through p38_MAPK in brain microvessel endothelial cells .
11302731	0	Cadmium	0,7	p53	35,38	Cadmium	p53	MESH:D002104	7157	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Cadmium induces phosphorylation of p53 at serine 15 in MCF-7 cells .
10938542	0	Cadmium	0,7	peroxidase	41,51	Cadmium	peroxidase	MESH:D002104	543313(Tax:4565)	Chemical	Gene	inhibition|amod|START_ENTITY END_ENTITY|nsubj|inhibition	Cadmium inhibition of a structural wheat peroxidase .
11800285	0	Cadmium	0,7	prolactin	58,67	Cadmium	prolactin	MESH:D002104	24683(Tax:10116)	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|END_ENTITY	Cadmium effects on dopamine turnover and plasma levels of prolactin , GH and ACTH .
25786521	0	Cadmium	0,7	steroidogenic_acute_regulatory_protein	42,80	Cadmium	steroidogenic acute regulatory protein	MESH:D002104	20845(Tax:10090)	Chemical	Gene	transcription|amod|START_ENTITY transcription|nmod|gene gene|amod|END_ENTITY	Cadmium up-regulates transcription of the steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- gene through phosphorylated CREB rather than SF-1 in K28 cells .
25069788	0	Cadmium	0,7	urokinase-type_plasminogen_activator_receptor	16,61	Cadmium	urokinase-type plasminogen activator receptor	MESH:D002104	5329	Chemical	Gene	induces|advmod|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Cadmium induces urokinase-type_plasminogen_activator_receptor expression and the cell invasiveness of human gastric_cancer cells via the ERK-1 / 2 , NF-kB , and AP-1 signaling pathways .
7010607	0	Cadmium-113	0,11	insulin	57,64	Cadmium-113	insulin	CHEBI:52620	280829(Tax:9913)	Chemical	Gene	studies|amod|START_ENTITY studies|nmod|END_ENTITY	Cadmium-113 nuclear magnetic resonance studies of bovine insulin : two-zinc insulin hexamer specifically binds calcium .
23615471	0	Caffeic_Acid_Phenethyl_Ester	0,28	Akt	118,121	Caffeic Acid Phenethyl Ester	Akt	MESH:C055494	207	Chemical	Gene	Proliferation|compound|START_ENTITY Proliferation|nmod|Signaling Signaling|compound|END_ENTITY	Caffeic_Acid_Phenethyl_Ester Suppresses Proliferation and Survival of TW2 .6 Human Oral_Cancer Cells via Inhibition of Akt Signaling .
23466879	0	Caffeic_Acid_phenethyl_ester	0,28	akt	93,96	Caffeic Acid phenethyl ester	akt	MESH:C055494	207	Chemical	Gene	START_ENTITY|nmod|treatment treatment|nmod|END_ENTITY	Caffeic_Acid_phenethyl_ester as a potential treatment for advanced_prostate_cancer targeting akt signaling .
23320037	0	Caffeic_Acid_phenethyl_ester	0,28	matrix_metalloproteinase-2	80,106	Caffeic Acid phenethyl ester	matrix metalloproteinase-2	MESH:C055494	4313	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|regulating regulating|dobj|END_ENTITY	Caffeic_Acid_phenethyl_ester inhibits oral_cancer cell metastasis by regulating matrix_metalloproteinase-2 and the mitogen-activated protein kinase pathway .
16497295	0	Caffeic_acid	0,12	BDNF	49,53	Caffeic acid	BDNF	MESH:C040048	12064(Tax:10090)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|decrease decrease|nmod|expression expression|amod|END_ENTITY	Caffeic_acid attenuates the decrease in cortical BDNF mRNA expression induced by exposure to forced swimming stress in mice .
25104643	0	Caffeic_acid	0,12	ERK1/2	30,36	Caffeic acid	ERK1/2	MESH:C040048	26417;26413	Chemical	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Caffeic_acid directly targets ERK1/2 to attenuate solar UV-induced skin_carcinogenesis .
19073879	0	Caffeic_acid	0,12	Fyn	68,71	Caffeic acid	Fyn	MESH:C040048	14360(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Caffeic_acid , a phenolic phytochemical in coffee , directly inhibits Fyn kinase activity and UVB-induced COX-2 expression .
23888332	0	Caffeic_acid	0,12	NF-kB	35,40	Caffeic acid	NF-kB	MESH:C040048	81736(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|amod|END_ENTITY	Caffeic_acid regulates LPS-induced NF-kB activation through NIK/IKK and c-Src/ERK signaling pathways in endothelial cells .
24138287	0	Caffeic_acid	0,12	PPAR-a	67,73	Caffeic acid	PPAR-a	MESH:C040048	5465	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Caffeic_acid induces keratinocyte differentiation by activation of PPAR-a .
16524889	0	Caffeic_acid	0,12	interleukin-10	60,74	Caffeic acid	interleukin-10	MESH:C040048	16153(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|nmod|END_ENTITY	Caffeic_acid suppresses UVB radiation-induced expression of interleukin-10 and activation of mitogen-activated protein kinases in mouse .
24583856	0	Caffeic_acid	0,12	tumor_necrosis_factor_alpha	31,58	Caffeic acid	tumor necrosis factor alpha	MESH:C040048	21926(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	Caffeic_acid reduces cutaneous tumor_necrosis_factor_alpha -LRB- TNF-a -RRB- , IL-6 and IL-1b levels and ameliorates skin_edema in acute and chronic model of cutaneous inflammation in mice .
24508943	0	Caffeic_acid_phenethyl_ester	0,28	5-lipoxygenase	32,46	Caffeic acid phenethyl ester	5-lipoxygenase	MESH:C055494	25290(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Caffeic_acid_phenethyl_ester , a 5-lipoxygenase enzyme inhibitor , alleviates diabetic_atherosclerotic manifestations : effect on vascular reactivity and stiffness .
26296470	0	Caffeic_acid_phenethyl_ester	0,28	CYP1A1	51,57	Caffeic acid phenethyl ester	CYP1A1	MESH:C055494	1543	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Caffeic_acid_phenethyl_ester inhibits 3-MC-induced CYP1A1 expression through induction of hypoxia-inducible_factor-1a .
26296470	0	Caffeic_acid_phenethyl_ester	0,28	CYP1A1	51,57	Caffeic acid phenethyl ester	CYP1A1	MESH:C055494	1543	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Caffeic_acid_phenethyl_ester inhibits 3-MC-induced CYP1A1 expression through induction of hypoxia-inducible_factor-1a .
14625298	0	Caffeic_acid_phenethyl_ester	0,28	NFkappaB	64,72	Caffeic acid phenethyl ester	NFkappaB	MESH:C055494	4790	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|inhibition inhibition|nmod|END_ENTITY	Caffeic_acid_phenethyl_ester induces apoptosis by inhibition of NFkappaB and activation of Fas in human breast_cancer MCF-7 cells .
26296470	0	Caffeic_acid_phenethyl_ester	0,28	hypoxia-inducible_factor-1a	90,117	Caffeic acid phenethyl ester	hypoxia-inducible factor-1a	MESH:C055494	3091	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|induction induction|nmod|END_ENTITY	Caffeic_acid_phenethyl_ester inhibits 3-MC-induced CYP1A1 expression through induction of hypoxia-inducible_factor-1a .
26296470	0	Caffeic_acid_phenethyl_ester	0,28	hypoxia-inducible_factor-1a	90,117	Caffeic acid phenethyl ester	hypoxia-inducible factor-1a	MESH:C055494	3091	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|induction induction|nmod|END_ENTITY	Caffeic_acid_phenethyl_ester inhibits 3-MC-induced CYP1A1 expression through induction of hypoxia-inducible_factor-1a .
25151996	0	Caffeic_acid_phenethyl_ester	0,28	interleukin-1b	66,80	Caffeic acid phenethyl ester	interleukin-1b	MESH:C055494	3553	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|effects effects|nmod|END_ENTITY	Caffeic_acid_phenethyl_ester inhibits the inflammatory effects of interleukin-1b in human corneal fibroblasts .
18850224	0	Caffeic_acid_phenethyl_ester	0,28	nuclear_factor_kappa_B	151,173	Caffeic acid phenethyl ester	nuclear factor kappa B	MESH:C055494	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	Caffeic_acid_phenethyl_ester inhibits invasion and expression of matrix metalloproteinase in SK-Hep1 human hepatocellular_carcinoma cells by targeting nuclear_factor_kappa_B .
24103753	0	Caffeic_acid_phenethyl_ester	0,28	phospholipase_D1	43,59	Caffeic acid phenethyl ester	phospholipase D1	MESH:C055494	5337	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	Caffeic_acid_phenethyl_ester downregulates phospholipase_D1 via direct binding and inhibition of NFkB transactivation .
17089110	0	Caffeine	0,8	CYP1A2	27,33	Caffeine	CYP1A2	MESH:D002110	1544	Chemical	Gene	N3-demethylation|amod|START_ENTITY N3-demethylation|appos|END_ENTITY	Caffeine N3-demethylation -LRB- CYP1A2 -RRB- in a population with an increased exposure to polychlorinated_biphenyls .
19519341	0	Caffeine	0,8	CYP1A2	56,62	Caffeine	CYP1A2	MESH:D002110	1544	Chemical	Gene	START_ENTITY|nmod|evaluation evaluation|nmod|END_ENTITY	Caffeine metabolic ratios for the in vivo evaluation of CYP1A2 , N-acetyltransferase_2 , xanthine oxidase and CYP2A6 enzymatic activities .
20853468	0	Caffeine	0,8	CYP1A2	41,47	Caffeine	CYP1A2	MESH:D002110	1544	Chemical	Gene	assay|amod|START_ENTITY assay|nmod|END_ENTITY	Caffeine and paraxanthine HPLC assay for CYP1A2 phenotype assessment using saliva and plasma .
23167901	0	Caffeine	0,8	CYP1A2	17,23	Caffeine	CYP1A2	MESH:D002110	24297(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Caffeine induces CYP1A2 expression in rat hepatocytes but not in human hepatocytes .
26588584	0	Caffeine	0,8	CYP1A2	67,73	Caffeine	CYP1A2	MESH:D002110	1544	Chemical	Gene	Impact|compound|START_ENTITY Modulated|nsubjpass|Impact Modulated|nmod|Variant Variant|compound|END_ENTITY	Caffeine Impact on Metabolic_Syndrome Components Is Modulated by a CYP1A2 Variant .
7756101	0	Caffeine	0,8	CYP1A2	83,89	Caffeine	CYP1A2	MESH:D002110	1544	Chemical	Gene	START_ENTITY|dep|comparison comparison|nmod|ratios ratios|acl|used used|xcomp|assess assess|dobj|activity activity|compound|END_ENTITY	Caffeine as a metabolic probe : a comparison of the metabolic ratios used to assess CYP1A2 activity .
7920691	0	Caffeine	0,8	CYP1A2	24,30	Caffeine	CYP1A2	MESH:D002110	1544	Chemical	Gene	START_ENTITY|nmod|probe probe|nmod|activity activity|compound|END_ENTITY	Caffeine as a probe for CYP1A2 activity : potential influence of renal factors on urinary phenotypic trait measurements .
8723732	0	Caffeine	0,8	CYP1A2	50,56	Caffeine	CYP1A2	MESH:D002110	24297(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|P4501A2 P4501A2|dep|induction induction|nmod|END_ENTITY	Caffeine induces cytochrome P4501A2 : induction of CYP1A2 by tea in rats .
9764962	0	Caffeine	0,8	CYP1A2	27,33	Caffeine	CYP1A2	MESH:D002110	1544	Chemical	Gene	based|nsubj|START_ENTITY based|dobj|measures measures|nmod|correlate correlate|compound|END_ENTITY	Caffeine based measures of CYP1A2 activity correlate with oral clearance of tacrine in patients with Alzheimer 's _ disease .
26203673	0	Caffeine	0,8	Cytochrome_P450_1A2	9,28	Caffeine	Cytochrome P450 1A2	MESH:D002110	1544	Chemical	Gene	Phenotype|compound|START_ENTITY Phenotype|compound|END_ENTITY	Caffeine Cytochrome_P450_1A2 Metabolic Phenotype Does Not Predict the Metabolism of Heterocyclic_Aromatic_Amines in Humans .
24915238	0	Caffeine	0,8	GRIN2A	50,56	Caffeine	GRIN2A	MESH:D002110	2903	Chemical	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	Caffeine interaction with glutamate receptor gene GRIN2A : Parkinson 's _ disease in Swedish population .
26132827	0	Caffeine	11,19	Interleukin-10	73,87	Caffeine	Interleukin-10	MESH:D002110	3586	Chemical	Gene	Supplementation|compound|START_ENTITY Effects|nmod|Supplementation END_ENTITY|nsubj|Effects	Effects of Caffeine Supplementation on Plasma and Blood Mononuclear Cell Interleukin-10 Levels After Exercise .
21617855	0	Caffeine	0,8	PTEN	36,40	Caffeine	PTEN	MESH:D002110	5728	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Caffeine activates tumor suppressor PTEN in sarcoma cells .
26911575	0	Caffeine	0,8	TGFb	18,22	Caffeine	TGFb	MESH:D002110	7040	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|compound|END_ENTITY	Caffeine inhibits TGFb activation in epithelial cells , interrupts fibroblast responses to TGFb , and reduces established fibrosis in ex vivo precision-cut lung slices .
15313438	0	Caffeine	0,8	TNF-alpha	20,29	Caffeine	TNF-alpha	MESH:D002110	7124	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|production production|amod|END_ENTITY	Caffeine suppresses TNF-alpha production via activation of the cyclic_AMP / protein kinase A pathway .
23698772	0	Caffeine	0,8	acetylcholinesterase	18,38	Caffeine	acetylcholinesterase	MESH:D002110	43	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Caffeine inhibits acetylcholinesterase , but not butyrylcholinesterase .
3110209	0	Caffeine	0,8	angiotensin_II	47,61	Caffeine	angiotensin II	MESH:D002110	24179(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Caffeine enhances the slow-pressor response to angiotensin_II in rats .
16522534	0	Caffeine	0,8	caspase-9	81,90	Caffeine	caspase-9	MESH:D002110	842	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|pathway pathway|amod|END_ENTITY	Caffeine induces apoptosis of human umbilical vein endothelial cells through the caspase-9 pathway .
7883225	0	Caffeine	0,8	cytochrome_P4501A2	24,42	Caffeine	cytochrome P4501A2	MESH:D002110	1544	Chemical	Gene	phenotyping|amod|START_ENTITY phenotyping|nmod|END_ENTITY	Caffeine phenotyping of cytochrome_P4501A2 , N-acetyltransferase , and xanthine oxidase in patients with familial_adenomatous_polyposis .
1521502	0	Caffeine	0,8	demethylase	9,20	Caffeine	demethylase	MESH:D002110	8932	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Caffeine demethylase activity in human and Dark Agouti rat liver microsomes .
24149694	0	Caffeine	0,8	growth_hormone	26,40	Caffeine	growth hormone	MESH:D002110	2688	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|response response|compound|END_ENTITY	Caffeine attenuates acute growth_hormone response to a single bout of resistance exercise .
6715798	0	Caffeine	0,8	growth_hormone	20,34	Caffeine	growth hormone	MESH:D002110	81668(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|amod|END_ENTITY	Caffeine stimulates growth_hormone secretion by cultured rat pituitary cells .
25992797	0	Caffeine	26,34	hA2AR	67,72	Caffeine	hA2AR	MESH:D002110	135	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of the Antagonist Caffeine to the Human Adenosine Receptor hA2AR in Nearly Physiological Conditions .
8332255	0	Caffeine	0,8	neurotensin	19,30	Caffeine	neurotensin	MESH:D002110	299757(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Caffeine regulates neurotensin and cholecystokinin messenger RNA expression in the rat striatum .
10069681	0	Caffeine	0,8	renin	25,30	Caffeine	renin	MESH:D002110	24715(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|secretion secretion|compound|END_ENTITY	Caffeine increases renal renin secretion in a rat model of genetic heart_failure .
1988669	0	Caffeine	0,8	renin	25,30	Caffeine	renin	MESH:D002110	5972	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|response response|compound|END_ENTITY	Caffeine potentiates the renin response to diazoxide in man .
2677316	0	Caffeine	0,8	renin	25,30	Caffeine	renin	MESH:D002110	24715(Tax:10116)	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|response response|compound|END_ENTITY	Caffeine potentiates the renin response to furosemide in rats .
15456933	0	Caffeine	0,8	sonic_hedgehog	17,31	Caffeine	sonic hedgehog	MESH:D002110	20423(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Caffeine induces sonic_hedgehog gene expression in cultured astrocytes and neurons .
23261059	0	Caffeoylserotonin	15,32	ERK	159,162	Caffeoylserotonin	ERK	null	26413(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of Caffeoylserotonin on inhibition of melanogenesis through the downregulation of MITF via the reduction of intracellular cAMP and acceleration of ERK activation in B16 murine melanoma cells .
23261059	0	Caffeoylserotonin	15,32	MITF	94,98	Caffeoylserotonin	MITF	null	17342(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of Caffeoylserotonin on inhibition of melanogenesis through the downregulation of MITF via the reduction of intracellular cAMP and acceleration of ERK activation in B16 murine melanoma cells .
3504383	0	Calbindin-D28K_1	16,32	CaBP	34,38	Calbindin-D28K 1	CaBP	null	12309(Tax:10090)	Chemical	Gene	Distribution|nmod|START_ENTITY Distribution|appos|END_ENTITY	Distribution of Calbindin-D28K_1 -LRB- CaBP -RRB- in the cerebral cortex and hippocampus of the epileptic -LRB- El -RRB- mouse .
16084527	0	Calcineurin	0,11	EXP-1	57,62	Calcineurin	EXP-1	CHEBI:53439	186801(Tax:6239)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Calcineurin regulates enteric muscle contraction through EXP-1 , excitatory GABA-gated channel , in C. _ elegans .
17113567	0	Calcineurin	0,11	KIN-29	27,33	Calcineurin	KIN-29	CHEBI:53439	180574(Tax:6239)	Chemical	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Calcineurin interacts with KIN-29 , a Ser/Thr kinase , in Caenorhabditis_elegans .
11279073	0	Calcineurin	0,11	MAPK_phosphatase-1	21,39	Calcineurin	MAPK phosphatase-1	CHEBI:53439	19252(Tax:10090)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	Calcineurin enhances MAPK_phosphatase-1 expression and p38_MAPK inactivation in cardiac myocytes .
10521511	0	Calcineurin	0,11	MEF2	21,25	Calcineurin	MEF2	CHEBI:53439	4205	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|compound|END_ENTITY	Calcineurin enhances MEF2 DNA binding activity in calcium-dependent survival of cerebellar granule neurons .
8631904	0	Calcineurin	0,11	NFAT1	43,48	Calcineurin	NFAT1	CHEBI:53439	4773	Chemical	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Calcineurin binds the transcription factor NFAT1 and reversibly regulates its activity .
10531391	0	Calcineurin	0,11	acetylcholinesterase	21,41	Calcineurin	acetylcholinesterase	CHEBI:53439	11423(Tax:10090)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|stability stability|amod|END_ENTITY	Calcineurin enhances acetylcholinesterase mRNA stability during C2-C12 muscle cell differentiation .
23688404	0	Calcipotriol	0,12	IL-22	23,28	Calcipotriol	IL-22	MESH:C055085	50616	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|compound|END_ENTITY	Calcipotriol modulates IL-22 receptor expression and keratinocyte proliferation in IL-22-induced epidermal_hyperplasia .
24419155	0	Calcipotriol	0,12	hCAP18	23,29	Calcipotriol	hCAP18	MESH:C055085	820	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Calcipotriol increases hCAP18 mRNA expression but inhibits extracellular LL37 peptide production in IL-17 / IL-22-stimulated normal human epidermal keratinocytes .
25709560	0	Calcite	100,107	Fetuin_A	29,37	Calcite	Fetuin A	MESH:D002119	197	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of Otoconial Proteins Fetuin_A , Osteopontin , and Otoconin_90 on the Nucleation and Growth of Calcite .
2537579	0	Calcitonin	0,10	CGRP	58,62	Calcitonin	CGRP	MESH:D002116	796	Chemical	Gene	receptor|compound|START_ENTITY receptor|dep|END_ENTITY	Calcitonin gene-related peptide receptor antagonist human CGRP - -LRB- 8-37 -RRB- .
19307750	0	Calcitonin	0,10	ERK1/2	59,65	Calcitonin	ERK1/2	MESH:D002116	5595;5594	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Calcitonin induces connective_tissue_growth_factor through ERK1/2 signaling in renal tubular cells .
11459804	0	Calcitonin	0,10	IL-6	19,23	Calcitonin	IL-6	MESH:D002116	16193(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|compound|END_ENTITY	Calcitonin induces IL-6 production via both PKA and PKC pathways in the pituitary_folliculo-stellate cell line .
12106478	0	Calcitonin	0,10	c-fos	60,65	Calcitonin	c-fos	MESH:D002116	314322(Tax:10116)	Chemical	Gene	Peptide|compound|START_ENTITY Stimulates|nsubj|Peptide Stimulates|dobj|Induction Induction|nmod|Expression Expression|amod|END_ENTITY	Calcitonin Gene-related Peptide Stimulates the Induction of c-fos Gene Expression in Rat Astrocyte Cultures .
8135834	0	Calcitonin	0,10	c-fos	94,99	Calcitonin	c-fos	MESH:D002116	14281(Tax:10090)	Chemical	Gene	acts|nsubj|START_ENTITY acts|xcomp|stimulate stimulate|dobj|expression expression|nmod|phenotypes phenotypes|amod|END_ENTITY	Calcitonin directly acts on mouse osteoblastic MC3T3-E1 cells to stimulate mRNA expression of c-fos , insulin-like_growth_factor-1 and osteoblastic phenotypes -LRB- type 1 collagen and osteocalcin -RRB- .
19307750	0	Calcitonin	0,10	connective_tissue_growth_factor	19,50	Calcitonin	connective tissue growth factor	MESH:D002116	1490	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Calcitonin induces connective_tissue_growth_factor through ERK1/2 signaling in renal tubular cells .
7232773	0	Calcitonin	0,10	gastrin	58,65	Calcitonin	gastrin	MESH:D002116	2520	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|END_ENTITY	Calcitonin and secretin inhibit bombesin-stimulated serum gastrin and gastric_acid secretion in man .
2545765	0	Calcitonin	0,10	growth_hormone	22,36	Calcitonin	growth hormone	MESH:D002116	2688	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|response response|amod|END_ENTITY	Calcitonin suppresses growth_hormone -LRB- GH -RRB- response to growth_hormone-releasing hormone -LRB- GHRH -RRB- in man .
7039348	0	Calcitonin	0,10	insulin	25,32	Calcitonin	insulin	MESH:D002116	3630	Chemical	Gene	modulation|compound|START_ENTITY modulation|nmod|END_ENTITY	Calcitonin modulation of insulin and glucagon secretion in man .
8032004	0	Calcitonin	0,10	insulin	72,79	Calcitonin	insulin	MESH:D002116	396145(Tax:9031)	Chemical	Gene	peptide|compound|START_ENTITY amyloid|nsubj|peptide amyloid|dobj|secretion secretion|compound|END_ENTITY	Calcitonin gene-related peptide and islet amyloid polypeptide stimulate insulin secretion in RINm5F cells through a common receptor coupled to a generation of cAMP .
8013390	0	Calcitonin	0,10	osteopontin	20,31	Calcitonin	osteopontin	MESH:D002116	100008982(Tax:9986)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Calcitonin inhibits osteopontin mRNA expression in isolated rabbit osteoclasts .
5124002	0	Calcitonin	0,10	parathyroid_hormone	26,45	Calcitonin	parathyroid hormone	MESH:D002116	5741	Chemical	Gene	stimulation|compound|START_ENTITY stimulation|nmod|secretion secretion|amod|END_ENTITY	Calcitonin stimulation of parathyroid_hormone secretion in vitro .
7690720	0	Calcitonin	0,10	parathyroid_hormone-related_protein	38,73	Calcitonin	parathyroid hormone-related protein	MESH:D002116	5744	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|transcription transcription|nmod|END_ENTITY	Calcitonin increases transcription of parathyroid_hormone-related_protein via cAMP .
9135823	0	Calcitonin	0,10	phospholipase_A2	20,36	Calcitonin	phospholipase A2	MESH:D002116	151056	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Calcitonin inhibits phospholipase_A2 and collagenase activity of human osteoarthritic chondrocytes .
10859495	0	Calcitonin	0,10	prolactin	25,34	Calcitonin	prolactin	MESH:D002116	24683(Tax:10116)	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|secretion secretion|compound|END_ENTITY	Calcitonin inhibition of prolactin secretion in lactating rats : mechanism of action .
12668864	0	Calcitonin	0,10	prolactin	20,29	Calcitonin	prolactin	MESH:D002116	24683(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	Calcitonin inhibits prolactin promoter activity in rat pituitary GGH3 cells : evidence for involvement of p42/44 mitogen-activated protein kinase in calcitonin action .
2115431	0	Calcitonin	0,10	prolactin	79,88	Calcitonin	prolactin	MESH:D002116	24683(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|nmod|END_ENTITY	Calcitonin inhibits basal and thyrotropin-releasing hormone-induced release of prolactin from anterior pituitary cells : evidence for a selective action exerted proximal to secretagogue-induced increases in cytosolic Ca2 + .
6213404	0	Calcitonin	0,10	pyruvate_carboxylase	21,41	Calcitonin	pyruvate carboxylase	MESH:D002116	25104(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|activity activity|amod|END_ENTITY	Calcitonin increases pyruvate_carboxylase activity in hepatic mitochondria of rats .
16381004	0	Calcitonin	0,10	urokinase-type_plasminogen_activator	39,75	Calcitonin	urokinase-type plasminogen activator	MESH:D002116	5328	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|nmod|END_ENTITY	Calcitonin stimulates the secretion of urokinase-type_plasminogen_activator from prostate_cancer cells : its possible implications on tumor cell invasion .
26276877	0	Calcitriol	43,53	AhR	14,17	Calcitriol	AhR	MESH:D002117	196	Chemical	Gene	Target|nmod|START_ENTITY Target|nsubj|END_ENTITY	Cutting Edge : AhR Is a Molecular Target of Calcitriol in Human T Cells .
26111345	0	Calcitriol	0,10	Dicer	21,26	Calcitriol	Dicer	MESH:D002117	23405	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Calcitriol increases Dicer expression and modifies the microRNAs signature in SiHa_cervical_cancer cells .
26111345	0	Calcitriol	0,10	Dicer	21,26	Calcitriol	Dicer	MESH:D002117	23405	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Calcitriol increases Dicer expression and modifies the microRNAs signature in SiHa_cervical_cancer cells .
2504804	0	Calcitriol	0,10	IL-2	50,54	Calcitriol	IL-2	MESH:D002117	3558	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|nmod|END_ENTITY	Calcitriol inhibits the PHA-induced production of IL-2 and IFN-gamma and the proliferation of human peripheral blood leukocytes while enhancing the surface expression of HLA class II molecules .
26881752	0	Calcitriol	0,10	Parathyroid_Hormone	26,45	Calcitriol	Parathyroid Hormone	MESH:D002117	5741	Chemical	Gene	Suppression|amod|START_ENTITY Suppression|nmod|END_ENTITY	Calcitriol Suppression of Parathyroid_Hormone Fails to Improve Skeletal Properties in an Animal Model of Chronic_Kidney_Disease .
23103122	0	Calcitriol	0,10	TNF-a	25,30	Calcitriol	TNF-a	MESH:D002117	7124	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	Calcitriol downregulates TNF-a and IL-6 expression in cultured placental cells from preeclamptic women .
17498257	0	Calcitriol	0,10	c-met	85,90	Calcitriol	c-met	MESH:D002117	4233	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Calcitriol inhibits the growth of MHCC97 heptocellular cell lines by down-modulating c-met and ERK expressions .
22182686	0	Calcitriol	0,10	interleukin-10	20,34	Calcitriol	interleukin-10	MESH:D002117	3586	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Calcitriol inhibits interleukin-10 expression in cultured human trophoblasts under normal and inflammatory conditions .
8070379	0	Calcitriol	0,10	osteopontin	25,36	Calcitriol	osteopontin	MESH:D002117	20750(Tax:10090)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Calcitriol regulation of osteopontin expression in mouse epidermal cells .
21592821	0	Calcitriol	0,10	prolactin	22,31	Calcitriol	prolactin	MESH:D002117	5617	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	Calcitriol stimulates prolactin expression in non-activated human peripheral blood mononuclear cells : breaking paradigms .
16815434	0	Calcitriol	0,10	protein_kinase_C	61,77	Calcitriol	protein kinase C	MESH:D002117	24681(Tax:10116)	Chemical	Gene	modulation|amod|START_ENTITY modulation|nmod|END_ENTITY	Calcitriol modulation of cardiac contractile performance via protein_kinase_C .
24630381	0	Calcitriol	0,10	receptor_for_advanced_glycation_end_products	21,65	Calcitriol	receptor for advanced glycation end products	MESH:D002117	81722(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Calcitriol modulates receptor_for_advanced_glycation_end_products -LRB- RAGE -RRB- in diabetic hearts .
17431122	0	Calcitriol	31,41	vascular_endothelial_growth_factor	79,113	Calcitriol	vascular endothelial growth factor	MESH:D002117	7422	Chemical	Gene	D3|appos|START_ENTITY inhibits|nsubj|D3 inhibits|dobj|pathway pathway|compound|END_ENTITY	1alpha,25-dihydroxyvitamin _ D3 -LRB- Calcitriol -RRB- inhibits hypoxia-inducible factor-1 / vascular_endothelial_growth_factor pathway in human cancer cells .
24120914	0	Calcitriol	0,10	vascular_endothelial_growth_factor	50,84	Calcitriol	vascular endothelial growth factor	MESH:D002117	22339(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	Calcitriol reduces thrombospondin-1 and increases vascular_endothelial_growth_factor in breast_cancer cells : implications for tumor angiogenesis .
11350048	0	Calcium	0,7	11beta-hydroxysteroid_dehydrogenase_type_2	33,75	Calcium	11beta-hydroxysteroid dehydrogenase type 2	MESH:D002118	3291	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Calcium inhibits human placental 11beta-hydroxysteroid_dehydrogenase_type_2 activity .
27010627	0	Calcium	38,45	5-Lipoxygenase	70,84	Calcium	5-Lipoxygenase	MESH:D002118	240	Chemical	Gene	Binding|compound|START_ENTITY Binding|nmod|END_ENTITY	Structural and Functional Analysis of Calcium Ion Mediated Binding of 5-Lipoxygenase to Nanodiscs .
3922966	0	Calcium	0,7	5-lipoxygenase	67,81	Calcium	5-lipoxygenase	MESH:D002118	11689(Tax:10090)	Chemical	Gene	ionophore|compound|START_ENTITY enables|nsubj|ionophore enables|xcomp|stimulate stimulate|dobj|END_ENTITY	Calcium ionophore enables soluble agonists to stimulate macrophage 5-lipoxygenase .
6818963	0	Calcium	0,7	5-lipoxygenase	27,41	Calcium	5-lipoxygenase	MESH:D002118	25290(Tax:10116)	Chemical	Gene	stimulation|amod|START_ENTITY stimulation|nmod|END_ENTITY	Calcium stimulation of the 5-lipoxygenase from RBL-1 cells .
9609696	0	Calcium	0,7	5-lipoxygenase	28,42	Calcium	5-lipoxygenase	MESH:D002118	240	Chemical	Gene	required|nsubjpass|START_ENTITY required|nmod|activity activity|amod|END_ENTITY	Calcium is not required for 5-lipoxygenase activity at high phosphatidyl_choline vesicle concentrations .
10822315	0	Calcium	0,7	ACE	26,29	Calcium	ACE	MESH:D002118	1636	Chemical	Gene	blockers|amod|START_ENTITY blockers|appos|inhibitors inhibitors|compound|END_ENTITY	Calcium channel blockers , ACE inhibitors , and the risk of cancer in hypertensive patients : a report from the Department of Health Hypertension Care Computing Project -LRB- DHCCP -RRB- OBJECTIVE : Recent studies have shown inconsistent results on the risk of cancer in hypertensive patients using calcium channel blockers -LRB- CCBs -RRB- and angiotensin-converting_enzyme -LRB- ACE -RRB- inhibitors .
8730344	0	Calcium	0,7	ACE	32,35	Calcium	ACE	MESH:D002118	1636	Chemical	Gene	blockers|amod|START_ENTITY blockers|nmod|END_ENTITY	Calcium channel blockers versus ACE inhibitors as antihypertensives in polycystic_kidney_disease .
25519917	0	Calcium	14,21	AT1	47,50	Calcium	AT1	MESH:D002118	185	Chemical	Gene	Signaling|compound|START_ENTITY Signaling|nmod|END_ENTITY	Modulation of Calcium Signaling of Angiotensin AT1 , Endothelin ETA , and ETB Receptors by Silibinin , Quercetin , Crocin , Diallyl_Sulfides , and Ginsenoside_Rb1 .
10366670	0	Calcium	0,7	ATPase	72,78	Calcium	ATPase	MESH:D002118	1769	Chemical	Gene	dependence|amod|START_ENTITY dependence|dep|END_ENTITY	Calcium dependence of Pi phosphorylation of sarcoplasmic reticulum Ca2 + - ATPase at low water content : water dependence of the E2 -- > E1 conversion .
12138099	0	Calcium	0,7	ATPase	51,57	Calcium	ATPase	MESH:D002118	1769	Chemical	Gene	transport|advmod|START_ENTITY transport|nmod|Ca Ca|dep|END_ENTITY	Calcium transport by sarcoplasmic reticulum Ca -LRB- 2 + -RRB- - ATPase .
129988	0	Calcium	0,7	ATPase	34,40	Calcium	ATPase	MESH:D002118	1769	Chemical	Gene	sensitivity|amod|START_ENTITY sensitivity|nmod|END_ENTITY	Calcium sensitivity of actomyosin ATPase : its modification by substitution of myosin sulfhydryl groups .
15601981	0	Calcium	0,7	ATPase	22,28	Calcium	ATPase	MESH:D002118	1769	Chemical	Gene	activities|compound|START_ENTITY activities|compound|END_ENTITY	Calcium and magnesium ATPase activities in women with varying BMIs .
16665816	0	Calcium	0,7	ATPase	123,129	Calcium	ATPase	MESH:D002118	1769	Chemical	Gene	Transport|compound|START_ENTITY Transport|dep|Characterization Characterization|nmod|Associated Associated|compound|END_ENTITY	Calcium Transport in Sealed Vesicles from Red Beet -LRB- Beta vulgaris L. -RRB- Storage Tissue : I. Characterization of a Ca-Pumping ATPase Associated with the Endoplasmic Reticulum .
22821874	0	Calcium	0,7	ATPase	89,95	Calcium	ATPase	MESH:D002118	1769	Chemical	Gene	mechanisms|amod|START_ENTITY +|nsubj|mechanisms +|dobj|END_ENTITY	Calcium binding and allosteric signaling mechanisms for the sarcoplasmic reticulum Ca + ATPase .
2969894	0	Calcium	0,7	ATPase	79,85	Calcium	ATPase	MESH:D002118	1769	Chemical	Gene	START_ENTITY|nmod|catalysis catalysis|nmod|END_ENTITY	Calcium dependence during single-cycle catalysis of the sarcoplasmic reticulum ATPase .
6299346	0	Calcium	0,7	ATPase	26,32	Calcium	ATPase	MESH:D002118	1769	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Calcium inhibition of the ATPase and phosphatase activities of -LRB- Na + + K + -RRB- - ATPase .
6299346	0	Calcium	0,7	ATPase	74,80	Calcium	ATPase	MESH:D002118	1769	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|dep|END_ENTITY	Calcium inhibition of the ATPase and phosphatase activities of -LRB- Na + + K + -RRB- - ATPase .
25902045	0	Calcium	27,34	Actinin_4	71,80	Calcium	Actinin 4	MESH:D002118	81	Chemical	Gene	Channel|compound|START_ENTITY Channel|nmod|END_ENTITY	Forskolin Regulates L-Type Calcium Channel through Interaction between Actinin_4 and b3 Subunit in Osteoblasts .
26198194	0	Calcium	48,55	Akt	80,83	Calcium	Akt	MESH:D002118	207	Chemical	Gene	Influx|compound|START_ENTITY Influx|nmod|END_ENTITY	Phosphatidylinositol_3-Kinase Couples Localised Calcium Influx to Activation of Akt in Central Nerve Terminals .
19948956	0	Calcium	0,7	BDNF	78,82	Calcium	BDNF	MESH:D002118	24225(Tax:10116)	Chemical	Gene	dopamine|nsubj|START_ENTITY dopamine|dobj|heteromer heteromer|nmod|production production|compound|END_ENTITY	Calcium signaling cascade links dopamine D1-D2 receptor heteromer to striatal BDNF production and neuronal growth .
8196672	0	Calcium	0,7	C-reactive_protein	31,49	Calcium	C-reactive protein	MESH:D002118	1401	Chemical	Gene	regions|compound|START_ENTITY regions|nmod|END_ENTITY	Calcium ion binding regions in C-reactive_protein : location and regulation of conformational changes .
10562341	0	Calcium	0,7	CA1	90,93	Calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	dependence|amod|START_ENTITY hippocampal|nsubj|dependence hippocampal|dobj|neurons neurons|nummod|END_ENTITY	Calcium dependence of depolarization-induced suppression of inhibition in rat hippocampal CA1 pyramidal neurons .
1359030	0	Calcium	0,7	CA1	66,69	Calcium	CA1	MESH:D002118	100720116	Chemical	Gene	dynamics|amod|START_ENTITY produced|nsubj|dynamics produced|nmod|activation activation|nmod|cells cells|nummod|END_ENTITY	Calcium concentration dynamics produced by synaptic activation of CA1 hippocampal pyramidal cells .
1846413	0	Calcium	0,7	CA1	97,100	Calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	effects|amod|START_ENTITY isolated|nsubj|effects isolated|dobj|neurons neurons|compound|END_ENTITY	Calcium antagonist effects on low-threshold -LRB- T-type -RRB- calcium current in rat isolated hippocampal CA1 pyramidal neurons .
2866099	0	Calcium	0,7	CA1	84,87	Calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	decrement|compound|START_ENTITY hippocampal|nsubj|decrement hippocampal|dobj|neurons neurons|nummod|END_ENTITY	Calcium and unit response decrement to locally applied glutamate on rat hippocampal CA1 neurons .
7472344	0	Calcium	0,7	CA1	90,93	Calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	involvement|amod|START_ENTITY release|nsubj|involvement release|nmod|END_ENTITY	Calcium channel involvement in GABAB receptor-mediated inhibition of GABA release in area CA1 of the rat hippocampus .
7936398	0	Calcium	0,7	CA1	112,115	Calcium	CA1	MESH:D002118	100720116	Chemical	Gene	START_ENTITY|nmod|dendritic_mitochondria_declines_along_the_apical_dendrites_of_pyramidal_neurons dendritic_mitochondria_declines_along_the_apical_dendrites_of_pyramidal_neurons|nmod|END_ENTITY	Calcium accumulation by dendritic_mitochondria_declines_along_the_apical_dendrites_of_pyramidal_neurons in area CA1 of guinea_pig hippocampal slices .
8784235	0	Calcium	0,7	CA1	50,53	Calcium	CA1	MESH:D002118	759	Chemical	Gene	movement|amod|START_ENTITY movement|nmod|END_ENTITY	Calcium movement in ischemia-tolerant hippocampal CA1 neurons after transient forebrain ischemia in gerbils .
8899608	0	Calcium	0,7	CA1	55,58	Calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	dependence|amod|START_ENTITY induced|nsubj|dependence induced|nmod|neurons neurons|amod|2-deoxyglucose 2-deoxyglucose|nmod|END_ENTITY	Calcium dependence of LTP induced by 2-deoxyglucose in CA1 neurons .
8923523	0	Calcium	0,7	CA1	30,33	Calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	currents|amod|START_ENTITY currents|nmod|END_ENTITY	Calcium currents in pyramidal CA1 neurons in vitro after kindling epileptogenesis in the hippocampus of the rat .
25916729	0	Calcium	25,32	CAPON	0,5	Calcium	CAPON	MESH:D002118	192363(Tax:10116)	Chemical	Gene	Handling|compound|START_ENTITY Handling|compound|END_ENTITY	CAPON Modulates Neuronal Calcium Handling and Cardiac Sympathetic Neurotransmission During Dysautonomia in Hypertension .
1706050	0	Calcium	0,7	CCl4	94,98	Calcium	CCl4	MESH:D002118	116637(Tax:10116)	Chemical	Gene	staining|advmod|START_ENTITY method|dep|staining method|acl|treated treated|nmod|together together|nmod|END_ENTITY	Calcium staining by the glyoxal-bis - -LRB- 2-hydroxyanil -RRB- - method in the livers of rats treated with CCl4 , diltiazem , and with both agents together .
19115832	0	Calcium	70,77	CD38	54,58	Calcium	CD38	MESH:D002118	952	Chemical	Gene	Induced|nmod|START_ENTITY Induced|compound|END_ENTITY	Conformational Closure of the Catalytic Site of Human CD38 Induced by Calcium -LRB- dagger -RRB- -LRB- double dagger -RRB- .
19117080	0	Calcium	70,77	CD38	54,58	Calcium	CD38	MESH:D002118	952	Chemical	Gene	Induced|nmod|START_ENTITY Induced|compound|END_ENTITY	Conformational Closure of the Catalytic Site of Human CD38 Induced by Calcium .
10398690	0	Calcium	0,7	Ca2	32,35	Calcium	Ca2	MESH:D002118	760	Chemical	Gene	+|amod|START_ENTITY +|compound|END_ENTITY	Calcium release flux underlying Ca2 + sparks of frog skeletal muscle .
16122797	0	Calcium	0,7	Ca2	40,43	Calcium	Ca2	MESH:D002118	760	Chemical	Gene	measurements|amod|START_ENTITY measurements|nmod|organelles organelles|nmod|+ +|amod|END_ENTITY	Calcium measurements in organelles with Ca2 + - sensitive fluorescent proteins .
17585332	0	Calcium	0,7	Ca2	30,33	Calcium	Ca2	MESH:D002118	760	Chemical	Gene	START_ENTITY|dep|transport transport|nsubj|+ +|compound|END_ENTITY	Calcium and cancer : targeting Ca2 + transport .
25855000	0	Calcium	0,7	CaCDPK1	66,73	Calcium	CaCDPK1	MESH:D002118	101500581	Chemical	Gene	properties|amod|START_ENTITY kinase|nsubj|properties kinase|dobj|1 1|appos|END_ENTITY	Calcium binding properties of calcium dependent protein kinase 1 -LRB- CaCDPK1 -RRB- from Cicer_arietinum .
22503562	0	Calcium	0,7	CaMKII	26,32	Calcium	CaMKII	MESH:D002118	818	Chemical	Gene	signaling|advmod|START_ENTITY signaling|nmod|END_ENTITY	Calcium signaling through CaMKII regulates hepatic glucose production in fasting and obesity .
23720740	0	Calcium	0,7	CaMKII	74,80	Calcium	CaMKII	MESH:D002118	818	Chemical	Gene	_|amod|START_ENTITY _|appos|END_ENTITY	Calcium and calmodulin-dependent_serine / threonine_protein_kinase_type_II _ -LRB- CaMKII -RRB- - mediated intramolecular opening of integrin cytoplasmic domain-associated protein-1 -LRB- ICAP-1a -RRB- negatively regulates b1 integrins .
24624086	0	Calcium	0,7	CaMKII	58,64	Calcium	CaMKII	MESH:D002118	818	Chemical	Gene	dysregulation|amod|START_ENTITY dysregulation|dep|role role|nmod|END_ENTITY	Calcium dysregulation in atrial_fibrillation : the role of CaMKII .
25303216	0	Calcium	102,109	CaMKII	156,162	Calcium	CaMKII	MESH:D002118	818	Chemical	Gene	Accumulation|compound|START_ENTITY Accumulation|nmod|Expression Expression|nmod|END_ENTITY	Correction : Anti-Epileptic Effect of Ganoderma Lucidum Polysaccharides by Inhibition of Intracellular Calcium Accumulation and Stimulation of Expression of CaMKII a in Epileptic_Hippocampal_Neurons .
12086646	0	Calcium	0,7	CaM_kinase_IV	43,56	Calcium	CaM kinase IV	MESH:D002118	814	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Calcium regulation of dendritic_growth via CaM_kinase_IV and CREB-mediated transcription .
19003215	0	Calcium	41,48	CaT1	62,66	Calcium	CaT1	MESH:D002118	6541	Chemical	Gene	Transporter|compound|START_ENTITY Characterization|nmod|Transporter Characterization|appos|END_ENTITY	Characterization of the Human Intestinal Calcium Transporter , CaT1 , Stably Expressed in CHO Cells .
25173401	0	Calcium	0,7	CaV1	8,12	Calcium	CaV1	MESH:D002118	857	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Calcium CaV1 Channel Subtype mRNA Expression in Parkinson 's _ Disease Examined by In Situ Hybridization .
25762319	0	Calcium	78,85	CaV1	109,113	Calcium	CaV1	MESH:D002118	857	Chemical	Gene	.1|compound|START_ENTITY .1|compound|END_ENTITY	Physiological and Pharmacological Modulation of the Embryonic Skeletal Muscle Calcium Channel Splice Variant CaV1 .1 e. CaV1 .1 e is the voltage-gated calcium channel splice variant of embryonic skeletal muscle .
25143538	0	Calcium	49,56	Cacna1a	41,48	Calcium	Cacna1a	MESH:D002118	12286(Tax:10090)	Chemical	Gene	Mutants|compound|START_ENTITY Mutants|compound|END_ENTITY	Flocculus Purkinje Cell Signals in Mouse Cacna1a Calcium Channel Mutants of Escalating Severity ; An Investigation of the Role of Firing Irregularity in Ataxia .
25251030	0	Calcium	46,53	Calbindin_D9k	57,70	Calcium	Calbindin D9k	MESH:D002118	795	Chemical	Gene	Study|nmod|START_ENTITY Study|nmod|END_ENTITY	Molecular Recognition Study on the Binding of Calcium to Calbindin_D9k Based on 3D Reference Interaction Site Model Theory .
27065884	0	Calcium	57,64	Calcium-Sensing_Receptor	0,24	Calcium	Calcium-Sensing Receptor	MESH:D002118	846	Chemical	Gene	Signaling|compound|START_ENTITY Target|nmod|Signaling END_ENTITY|dep|Target	Calcium-Sensing_Receptor : A Key Target for Extracellular Calcium Signaling in Neurons .
26334624	0	Calcium	42,49	Cobl	20,24	Calcium	Cobl	MESH:D002118	23242	Chemical	Gene	Controlled|nmod|START_ENTITY Controlled|nsubjpass|END_ENTITY	The Actin Nucleator Cobl Is Controlled by Calcium and Calmodulin .
9201910	0	Calcium	0,7	E-cadherin	39,49	Calcium	E-cadherin	MESH:D002118	999	Chemical	Gene	START_ENTITY|dobj|binding binding|nmod|domains domains|amod|END_ENTITY	Calcium binding and homoassociation of E-cadherin domains .
15150258	0	Calcium	0,7	ERK	22,25	Calcium	ERK	MESH:D002118	5594	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Calcium activation of ERK mediated by calmodulin kinase I. Elevated intracellular Ca -LRB- 2 + -RRB- triggers numerous signaling pathways including protein kinases such as the calmodulin-dependent kinases -LRB- CaMKs -RRB- and the extracellular signal-regulated kinases -LRB- ERKs -RRB- .
15713425	0	Calcium	0,7	ERK	153,156	Calcium	ERK	MESH:D002118	5594	Chemical	Gene	START_ENTITY|dep|studies studies|nmod|activation activation|nmod|extracellular_signal_regulated_kinase extracellular_signal_regulated_kinase|appos|END_ENTITY	Calcium and the replication of human vascular smooth muscle cells : studies on the activation and translocation of extracellular_signal_regulated_kinase -LRB- ERK -RRB- and cyclin_D1 expression .
17074386	0	Calcium	0,7	ERK	88,91	Calcium	ERK	MESH:D002118	24338(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY mediates|nsubj|release mediates|dobj|activation activation|nmod|END_ENTITY	Calcium release by ryanodine receptors mediates hydrogen_peroxide-induced activation of ERK and CREB phosphorylation in N2a cells and hippocampal neurons .
19704446	0	Calcium	0,7	ERK	18,21	Calcium	ERK	MESH:D002118	5594	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Calcium regulates ERK signaling by modulating its protein-protein interactions .
12475968	0	Calcium	0,7	Ets1	82,86	Calcium	Ets1	MESH:D002118	2113	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Calcium regulation of GM-CSF by calmodulin-dependent kinase II phosphorylation of Ets1 .
24140714	0	Calcium	0,7	FGF-23	18,24	Calcium	FGF-23	MESH:D002118	64654(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Calcium regulates FGF-23 expression in bone .
26825086	0	Calcium	32,39	Fetuin-A	0,8	Calcium	Fetuin-A	MESH:D002118	197	Chemical	Gene	Associated|nmod|START_ENTITY Associated|nsubj|END_ENTITY	Fetuin-A is Associated to Serum Calcium and AHSG T256S Genotype but Not to Coronary_Artery_Calcification .
12475968	0	Calcium	0,7	GM-CSF	22,28	Calcium	GM-CSF	MESH:D002118	1437	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Calcium regulation of GM-CSF by calmodulin-dependent kinase II phosphorylation of Ets1 .
25310566	0	Calcium	33,40	GPR41	154,159	Calcium	GPR41	MESH:D002118	365228(Tax:10116)	Chemical	Gene	Levels|compound|START_ENTITY Levels|nmod|END_ENTITY	Butyrate Increases Intracellular Calcium Levels and Enhances Growth_Hormone Release from Rat Anterior Pituitary Cells via the G-Protein-Coupled Receptors GPR41 and 43 .
26160593	0	Calcium	75,82	Galanin_Receptor_2	95,113	Calcium	Galanin Receptor 2	MESH:D002118	14428(Tax:10090)	Chemical	Gene	Channel|compound|START_ENTITY Channel|nmod|END_ENTITY	Spexin Enhances Bowel Movement through Activating L-type Voltage-dependent Calcium Channel via Galanin_Receptor_2 in Mice .
9887004	0	Calcium	0,7	Galphaq	61,68	Calcium	Galphaq	MESH:D002118	81666(Tax:10116)	Chemical	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Calcium signaling in rat pancreatic acinar cells : a role for Galphaq , Galpha11 , and Galpha14 .
20542070	0	Calcium	0,7	GlyT1	85,90	Calcium	GlyT1	MESH:D002118	6536	Chemical	Gene	modification|amod|START_ENTITY modification|nmod|END_ENTITY	Calcium dependent modification of distal C-terminal sequences of glycine transporter GlyT1 .
17241740	0	Calcium	0,7	GnRH	50,54	Calcium	GnRH	MESH:D002118	2796	Chemical	Gene	influx|amod|START_ENTITY required|nsubjpass|influx required|nmod|activity activity|amod|END_ENTITY	Calcium influx and DREAM protein are required for GnRH gene expression pulse activity .
18658155	0	Calcium	0,7	Hsp70	63,68	Calcium	Hsp70	MESH:D002118	3308	Chemical	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Calcium signaling in dendritic cells by human or mycobacterial Hsp70 is caused by contamination and is not required for Hsp70-mediated enhancement of cross-presentation .
21447702	0	Calcium	0,7	IGF1R	37,42	Calcium	IGF1R	MESH:D002118	16001(Tax:10090)	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|compound|END_ENTITY	Calcium and osteoprotegerin regulate IGF1R expression to inhibit vascular_calcification .
26729804	0	Calcium	25,32	IL-2	58,62	Calcium	IL-2	MESH:D002118	3558	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Association of CD147 and Calcium Exporter PMCA4 Uncouples IL-2 Expression from Early TCR Signaling .
15081409	0	Calcium	0,7	IQGAP1	57,63	Calcium	IQGAP1	MESH:D002118	8826	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	Calcium negatively modulates calmodulin interaction with IQGAP1 .
22037186	0	Calcium	0,7	InsP3R	113,119	Calcium	InsP3R	MESH:D002118	16438(Tax:10090)	Chemical	Gene	homeostasis|amod|START_ENTITY altered|nsubjpass|homeostasis altered|nmod|modulation modulation|nmod|channels channels|amod|END_ENTITY	Calcium homeostasis in vascular smooth muscle cells is altered in type 2 diabetes by Bcl-2 protein modulation of InsP3R calcium release channels .
24763850	0	Calcium	0,7	Insulin	84,91	Calcium	Insulin	MESH:D002118	3630	Chemical	Gene	concentrations|compound|START_ENTITY concentrations|dep|Resistance Resistance|amod|END_ENTITY	Calcium and phosphate concentrations and future development of type 2 diabetes : the Insulin Resistance Atherosclerosis Study .
25605997	0	Calcium	58,65	Interleukin-8	40,53	Calcium	Interleukin-8	MESH:D002118	3576	Chemical	Gene	Signaling|compound|START_ENTITY END_ENTITY|nmod|Signaling	Peptidoglycan Induces the Production of Interleukin-8 via Calcium Signaling in Human Gingival Epithelium .
26121493	0	Calcium	49,56	Itpkb	34,39	Calcium	Itpkb	MESH:D002118	320404(Tax:10090)	Chemical	Gene	Signaling|compound|START_ENTITY Augments|dobj|Signaling Augments|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of the Inositol Kinase Itpkb Augments Calcium Signaling in Lymphocytes and Reveals a Novel Strategy to Treat Autoimmune_Disease .
11543084	0	Calcium	0,7	MIR	152,155	Calcium	MIR	MESH:D002118	220972	Chemical	Gene	utilization|amod|START_ENTITY END_ENTITY|nsubj|utilization	Calcium utilization by quail embryos during activities preceding space flight and during embryogenesis in microgravity aboard the orbital space station MIR .
25107449	0	Calcium	93,100	MicroRNA-21	38,49	Calcium	MicroRNA-21	MESH:D002118	406991	Chemical	Gene	Current|compound|START_ENTITY END_ENTITY|nmod|Current	Chronic Atrial_Fibrillation Increases MicroRNA-21 in Human Atrial Myocytes Decreasing L-Type Calcium Current .
18391215	0	Calcium	0,7	Myo1c	49,54	Calcium	Myo1c	MESH:D002118	4641	Chemical	Gene	sensitivity|amod|START_ENTITY sensitivity|nmod|END_ENTITY	Calcium sensitivity of the cross-bridge cycle of Myo1c , the adaptation motor in the inner ear .
20331430	0	Calcium	0,7	NF-kappaB	45,54	Calcium	NF-kappaB	MESH:D002118	4790	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Calcium signal-initiated early activation of NF-kappaB in neurons is a neuroprotective event in response to kainic_acid-induced excitotoxicity .
25049596	0	Calcium	25,32	NaPi-IIb	72,80	Calcium	NaPi-IIb	MESH:D002118	10568	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	The Influence of Dietary Calcium and Phosphorus Imbalance on Intestinal NaPi-IIb and Calbindin mRNA Expression and Tibia Parameters of Broilers .
21945734	0	Calcium	0,7	ORAI1	18,23	Calcium	ORAI1	MESH:D002118	84876	Chemical	Gene	entry|amod|START_ENTITY entry|nmod|END_ENTITY	Calcium entry via ORAI1 regulates glioblastoma cell proliferation and apoptosis .
17452328	0	Calcium	0,7	Orai1	47,52	Calcium	Orai1	MESH:D002118	84876	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Calcium inhibition and calcium potentiation of Orai1 , Orai2 , and Orai3 calcium release-activated calcium channels .
24307733	0	Calcium	0,7	Orai1	22,27	Calcium	Orai1	MESH:D002118	84876	Chemical	Gene	signaling|compound|START_ENTITY signaling|nmod|END_ENTITY	Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation .
26635623	0	Calcium	62,69	Orai1	5,10	Calcium	Orai1	MESH:D002118	109305(Tax:10090)	Chemical	Gene	Entry|compound|START_ENTITY Involved|nmod|Entry Involved|nsubjpass|END_ENTITY	Both Orai1 and TRPC1 are Involved in Excessive Store-Operated Calcium Entry in Striatal Neurons Expressing Mutant Huntingtin Exon 1 .
26916730	0	Calcium	35,42	Orai1	14,19	Calcium	Orai1	MESH:D002118	109305(Tax:10090)	Chemical	Gene	Channel|compound|START_ENTITY Channel|compound|END_ENTITY	Inhibition of Orai1 Store-Operated Calcium Channel Prevents Foam Cell Formation and Atherosclerosis .
26940090	0	Calcium	33,40	Orai1	12,17	Calcium	Orai1	MESH:D002118	84876	Chemical	Gene	Protects|compound|START_ENTITY Protects|compound|END_ENTITY	Blockade of Orai1 Store-Operated Calcium Entry Protects against Renal_Fibrosis .
11600670	0	Calcium	0,7	P2X1	47,51	Calcium	P2X1	MESH:D002118	25505(Tax:10116)	Chemical	Gene	START_ENTITY|acl|signalling signalling|nmod|END_ENTITY	Calcium signalling through nucleotide receptor P2X1 in rat portal vein myocytes .
26101220	0	Calcium	0,7	P2X4	24,28	Calcium	P2X4	MESH:D002118	5025	Chemical	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	Calcium release through P2X4 activates calmodulin to promote endolysosomal membrane fusion .
9803312	0	Calcium	0,7	P2Y2	47,51	Calcium	P2Y2	MESH:D002118	5029	Chemical	Gene	START_ENTITY|acl|signalling signalling|nmod|END_ENTITY	Calcium signalling through nucleotide receptor P2Y2 in cultured human vascular endothelium .
21147983	0	Calcium	0,7	PICK1	19,24	Calcium	PICK1	MESH:D002118	9463	Chemical	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	Calcium binding to PICK1 is essential for the intracellular retention of AMPA receptors underlying long-term depression .
24448801	0	Calcium	0,7	PMCA4	58,63	Calcium	PMCA4	MESH:D002118	381290(Tax:10090)	Chemical	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Calcium efflux activity of plasma membrane Ca2 + ATPase-4 -LRB- PMCA4 -RRB- mediates cell cycle progression in vascular smooth muscle cells .
26729804	0	Calcium	25,32	PMCA4	42,47	Calcium	PMCA4	MESH:D002118	493	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Association of CD147 and Calcium Exporter PMCA4 Uncouples IL-2 Expression from Early TCR Signaling .
1411258	0	Calcium	0,7	PTH	53,56	Calcium	PTH	MESH:D002118	5741	Chemical	Gene	technique|amod|START_ENTITY technique|dep|suppression suppression|nmod|END_ENTITY	Calcium clamp technique : suppression of serum intact PTH by induced hypercalcaemia in normal man and primary_hyperparathyroidism .
17187837	0	Calcium	0,7	PTH	55,58	Calcium	PTH	MESH:D002118	5741	Chemical	Gene	START_ENTITY|nmod|response response|nmod|D3 D3|compound|END_ENTITY	Calcium uptake and membrane trafficking in response to PTH or 25 -LRB- OH -RRB- D3 in polarized intestinal epithelial cells .
21747853	0	Calcium	66,73	PTH	134,137	Calcium	PTH	MESH:D002118	24694(Tax:10116)	Chemical	Gene	Induced|nmod|START_ENTITY Induced|nmod|Forms Forms|compound|END_ENTITY	Influence of Secondary Hyperparathyroidism Induced by Low Dietary Calcium , Vitamin_D_Deficiency , and Renal_Failure on Circulating Rat PTH Molecular Forms .
26107510	0	Calcium	31,38	PTH	70,73	Calcium	PTH	MESH:D002118	5741	Chemical	Gene	START_ENTITY|nmod|Mortality-Predictability Mortality-Predictability|nmod|END_ENTITY	Effect Modifying Role of Serum Calcium on Mortality-Predictability of PTH and Alkaline Phosphatase in Hemodialysis Patients : An Investigation Using Data from the Taiwan Renal Registry Data System from 2005 to 2012 .
8643172	0	Calcium	0,7	PTH	27,30	Calcium	PTH	MESH:D002118	5741	Chemical	Gene	START_ENTITY|dobj|variations variations|compound|END_ENTITY	Calcium balance and intact PTH variations during haemodiafiltration .
26639846	0	Calcium	98,105	Parathyroid_Hormone	50,69	Calcium	Parathyroid Hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	Decrease|nmod|START_ENTITY Decrease|compound|END_ENTITY	Zinc_Deficiency Increases Serum Concentrations of Parathyroid_Hormone through a Decrease in Serum Calcium and Induces Bone_Fragility in Rats .
26198194	0	Calcium	48,55	Phosphatidylinositol_3-Kinase	0,29	Calcium	Phosphatidylinositol 3-Kinase	MESH:D002118	5293	Chemical	Gene	Influx|compound|START_ENTITY Influx|compound|END_ENTITY	Phosphatidylinositol_3-Kinase Couples Localised Calcium Influx to Activation of Akt in Central Nerve Terminals .
26793121	0	Calcium	36,43	RyR1	31,35	Calcium	RyR1	MESH:D002118	6261	Chemical	Gene	Channels|compound|START_ENTITY Channels|compound|END_ENTITY	Critical Role of Intracellular RyR1 Calcium Release Channels in Skeletal Muscle Function and Disease .
15720454	0	Calcium	0,7	RyR2	147,151	Calcium	RyR2	MESH:D002118	6262	Chemical	Gene	antagonism|amod|START_ENTITY reduces|nsubj|antagonism reduces|nmod|patients patients|nmod|mutations mutations|amod|END_ENTITY	Calcium channel antagonism reduces exercise-induced ventricular_arrhythmias in catecholaminergic polymorphic ventricular_tachycardia patients with RyR2 mutations .
25603835	0	Calcium	64,71	RyR2	14,18	Calcium	RyR2	MESH:D002118	6262	Chemical	Gene	ion|nsubj|START_ENTITY UNASSIGNED|parataxis|ion UNASSIGNED|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of RyR2 by Sarcoplasmic Reticulum Ca -LRB- 2 + -RRB- UNASSIGNED : Calcium -LRB- Ca -LRB- 2 + -RRB- -RRB- is arguably the most important ion involved in the contraction of the heart .
26121139	0	Calcium	142,149	RyR2	49,53	Calcium	RyR2	MESH:D002118	20191(Tax:10090)	Chemical	Gene	Waves|compound|START_ENTITY Determines|nmod|Waves Determines|nsubj|Activity Activity|nmod|Receptors Receptors|appos|END_ENTITY	Channel Activity of Cardiac_Ryanodine Receptors -LRB- RyR2 -RRB- Determines Potency and Efficacy of Flecainide and R-Propafenone against Arrhythmogenic Calcium Waves in Ventricular Cardiomyocytes .
22053056	0	Calcium	0,7	STIM1	59,64	Calcium	STIM1	MESH:D002118	20866(Tax:10090)	Chemical	Gene	START_ENTITY|dep|roles roles|nmod|END_ENTITY	Calcium signaling in mouse oocyte maturation : the roles of STIM1 , ORAI1 and SOCE .
25558393	0	Calcium	39,46	STIM1	0,5	Calcium	STIM1	MESH:D002118	6786	Chemical	Gene	Channels|compound|START_ENTITY Activates|dobj|Channels Activates|nsubj|Protein Protein|compound|END_ENTITY	STIM1 Protein Activates Store-Operated Calcium Channels in Cellular Model of Huntington 's _ Disease .
26921571	0	Calcium	136,143	Somatostatin	51,63	Calcium	Somatostatin	MESH:D002118	6750	Chemical	Gene	sulfate|appos|START_ENTITY sulfate|compound|END_ENTITY	Congenital_fibrosarcoma in complete remission with Somatostatin , Bromocriptine , Retinoids , Vitamin_D3 , Vitamin_E , Vitamin_C , Melatonin , Calcium , Chondroitin sulfate associated with low doses of Cyclophosphamide in a 14-year Follow up .
23824669	0	Calcium	96,103	Src	0,3	Calcium	Src	MESH:D002118	20779(Tax:10090)	Chemical	Gene	Increase|nmod|START_ENTITY Independent|nmod|Increase Independent|nsubj|Pancreatic_Acinar_Injury Pancreatic_Acinar_Injury|compound|END_ENTITY	Src Dependent Pancreatic_Acinar_Injury Can Be Initiated Independent of an Increase in Cytosolic Calcium .
26445027	0	Calcium	0,7	Starmaker	97,106	Calcium	Starmaker	MESH:D002118	386700(Tax:7955)	Chemical	Gene	START_ENTITY|nmod|Protein Protein|compound|END_ENTITY	Calcium Ion Binding Properties and the Effect of Phosphorylation on the Intrinsically Disordered Starmaker Protein .
25422940	0	Calcium	35,42	Synaptotagmin-7	0,15	Calcium	Synaptotagmin-7	MESH:D002118	54525(Tax:10090)	Chemical	Gene	Sensor|compound|START_ENTITY Sensor|nsubj|END_ENTITY	Synaptotagmin-7 Is an Asynchronous Calcium Sensor for Synaptic Transmission in Neurons Expressing SNAP-23 .
15593122	0	Calcium	0,7	TNF-alpha	54,63	Calcium	TNF-alpha	MESH:D002118	21926(Tax:10090)	Chemical	Gene	target|nsubj|START_ENTITY target|dobj|pathway pathway|amod|END_ENTITY	Calcium and 1 alpha,25-dihydroxyvitamin _ D3 target the TNF-alpha pathway to suppress experimental inflammatory_bowel_disease .
9585152	0	Calcium	0,7	TNF-alpha	43,52	Calcium	TNF-alpha	MESH:D002118	24835(Tax:10116)	Chemical	Gene	signaling|compound|START_ENTITY kinase|nsubj|signaling kinase|dobj|C C|nmod|secretion secretion|amod|END_ENTITY	Calcium signaling and protein kinase C for TNF-alpha secretion in a rat mast cell line .
25915383	0	Calcium	14,21	TRPC3	32,37	Calcium	TRPC3	MESH:D002118	7222	Chemical	Gene	Force|compound|START_ENTITY Force|compound|END_ENTITY	Abstract 169 : Calcium Entry Via TRPC3 Channels Transduce Mechanical Force And Accerelate Wound Contraction .
25915383	0	Calcium	14,21	TRPC3	32,37	Calcium	TRPC3	MESH:D002118	7222	Chemical	Gene	Force|compound|START_ENTITY Force|compound|END_ENTITY	Abstract 169 : Calcium Entry Via TRPC3 Channels Transduce Mechanical Force And Accerelate Wound Contraction .
25707820	0	Calcium	72,79	TRPC5	66,71	Calcium	TRPC5	MESH:D002118	7224	Chemical	Gene	Channels|compound|START_ENTITY Channels|compound|END_ENTITY	-LRB- - -RRB- - Englerin ___ A is a Potent and Selective Activator of TRPC4 and TRPC5 Calcium Channels .
21959089	0	Calcium	0,7	TRPC6	18,23	Calcium	TRPC6	MESH:D002118	7225	Chemical	Gene	entry|amod|START_ENTITY entry|nmod|END_ENTITY	Calcium entry via TRPC6 mediates albumin overload-induced endoplasmic_reticulum_stress and apoptosis in podocytes .
26202353	0	Calcium	49,56	TRPC6	85,90	Calcium	TRPC6	MESH:D002118	7225	Chemical	Gene	Entry|compound|START_ENTITY Entry|nmod|Channels Channels|compound|END_ENTITY	Alpha1-Adrenergic Receptor Activation Stimulates Calcium Entry and Proliferation via TRPC6 Channels in Cultured Human Mesangial Cells .
26202353	0	Calcium	49,56	TRPC6	85,90	Calcium	TRPC6	MESH:D002118	7225	Chemical	Gene	Entry|compound|START_ENTITY Entry|nmod|Channels Channels|compound|END_ENTITY	Alpha1-Adrenergic Receptor Activation Stimulates Calcium Entry and Proliferation via TRPC6 Channels in Cultured Human Mesangial Cells .
19587221	0	Calcium	0,7	TRPM1	93,98	Calcium	TRPM1	MESH:D002118	4308	Chemical	Gene	homeostasis|amod|START_ENTITY homeostasis|dep|role role|nmod|transient_receptor_potential_melastatin_1 transient_receptor_potential_melastatin_1|appos|END_ENTITY	Calcium homeostasis in human melanocytes : role of transient_receptor_potential_melastatin_1 -LRB- TRPM1 -RRB- and its regulation by ultraviolet light .
25305668	0	Calcium	99,106	TRPM2	160,165	Calcium	TRPM2	MESH:D002118	28240(Tax:10090)	Chemical	Gene	Overload|compound|START_ENTITY Apoptosis|dep|Overload Apoptosis|parataxis|Involvement Involvement|dep|Channels Channels|compound|END_ENTITY	Homocysteine and Cytosolic_GSH Depletion Induce Apoptosis and Oxidative Toxicity Through Cytosolic Calcium Overload in Hippocampus of Aged Mice : Involvement of TRPM2 and TRPV1 Channels .
24794232	0	Calcium	0,7	TRPV1	18,23	Calcium	TRPV1	MESH:D002118	7442	Chemical	Gene	entry|amod|START_ENTITY entry|nmod|END_ENTITY	Calcium entry via TRPV1 but not ASICs induces neuropeptide release from sensory neurons .
18751967	0	Calcium	0,7	TRPV4	161,166	Calcium	TRPV4	MESH:D002118	59341	Chemical	Gene	elevation|compound|START_ENTITY involves|nsubj|elevation involves|dobj|activation activation|nmod|END_ENTITY	Calcium elevation in mouse pancreatic beta cells evoked by extracellular human islet amyloid polypeptide involves activation of the mechanosensitive ion channel TRPV4 .
25809269	0	Calcium	38,45	TRPV4	32,37	Calcium	TRPV4	MESH:D002118	59341	Chemical	Gene	Sparklets|compound|START_ENTITY Sparklets|compound|END_ENTITY	Stochastic Model of Endothelial TRPV4 Calcium Sparklets : Effect of Bursting and Cooperativity on EDH .
25378396	0	Calcium	26,33	TRPV5	84,89	Calcium	TRPV5	MESH:D002118	56302	Chemical	Gene	Transient_Receptor_Potential_Vanilloid_5|compound|START_ENTITY Transient_Receptor_Potential_Vanilloid_5|appos|END_ENTITY	Klotho Up-regulates Renal Calcium Channel Transient_Receptor_Potential_Vanilloid_5 -LRB- TRPV5 -RRB- by Intra - and Extracellular N-glycosylation-dependent Mechanisms .
26089600	0	Calcium	116,123	TRPV5	48,53	Calcium	TRPV5	MESH:D002118	56302	Chemical	Gene	Patients|compound|START_ENTITY Multiplicity|nmod|Patients Associated|nmod|Multiplicity Associated|nsubj|Polymorphism Polymorphism|nmod|Gene Gene|compound|END_ENTITY	A Single Nucleotide Polymorphism -LRB- rs4236480 -RRB- in TRPV5 Calcium Channel Gene Is Associated with Stone Multiplicity in Calcium Nephrolithiasis Patients .
26089600	0	Calcium	54,61	TRPV5	48,53	Calcium	TRPV5	MESH:D002118	56302	Chemical	Gene	Gene|compound|START_ENTITY Gene|compound|END_ENTITY	A Single Nucleotide Polymorphism -LRB- rs4236480 -RRB- in TRPV5 Calcium Channel Gene Is Associated with Stone Multiplicity in Calcium Nephrolithiasis Patients .
26837804	0	Calcium	62,69	TRPV5	78,83	Calcium	TRPV5	MESH:D002118	56302	Chemical	Gene	Induced|compound|START_ENTITY Induced|compound|END_ENTITY	Molecular Modeling of the Structural and Dynamical Changes in Calcium Channel TRPV5 Induced by the African-Specific A563T Variation .
17002582	0	Calcium	0,7	TRPV6	16,21	Calcium	TRPV6	MESH:D002118	55503	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Calcium channel TRPV6 expression in human duodenum : different relationships to the vitamin_D system and aging in men and women .
26457814	0	Calcium	22,29	TRPV6	16,21	Calcium	TRPV6	MESH:D002118	55503	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|compound|END_ENTITY	Optimization of TRPV6 Calcium Channel Inhibitors Using a 3D Ligand-Based Virtual Screening Method .
19215446	0	Calcium	53,60	Thyrotrophin-Releasing_Hormone	0,30	Calcium	Thyrotrophin-Releasing Hormone	MESH:D002118	7200	Chemical	Gene	Concentration|compound|START_ENTITY Concentration|compound|END_ENTITY	Thyrotrophin-Releasing_Hormone Raises Cytosolic Free Calcium Concentration in Human Adenomatous Somatotrophs and Corticotrophs ; Comparison with in vivo Responsiveness to Thyrotrophin-Releasing_Hormone in Patients with Acromegaly or Cushing 's _ Disease .
20432164	0	Calcium	0,7	VDR	20,23	Calcium	VDR	MESH:D002118	7421	Chemical	Gene	genotypes|advmod|START_ENTITY genotypes|nsubj|END_ENTITY	Calcium , vitamin_D , VDR genotypes , and epigenetic and genetic changes in rectal_tumors .
26211511	0	Calcium	24,31	VDR	85,88	Calcium	VDR	MESH:D002118	22337(Tax:10090)	Chemical	Gene	Accompany|compound|START_ENTITY Changes|nmod|Accompany Changes|dep|Loss Loss|nmod|Receptor Receptor|appos|END_ENTITY	Compensatory Changes in Calcium Metabolism Accompany the Loss of Vitamin_D Receptor -LRB- VDR -RRB- From the Distal Intestine and Kidney of Mice .
7720667	0	Calcium	0,7	androgen_receptor	22,39	Calcium	androgen receptor	MESH:D002118	367	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Calcium regulation of androgen_receptor expression in the human prostate_cancer cell line LNCaP .
10090417	0	Calcium	0,7	angiotensin_II	29,43	Calcium	angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	signaling|compound|START_ENTITY induced|nsubj|signaling induced|nmod|END_ENTITY	Calcium signaling induced by angiotensin_II in the pancreatic acinar cell line AR42J .
10484357	0	Calcium	0,7	angiotensin_II	43,57	Calcium	angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	influx|amod|START_ENTITY influx|nmod|stimulation stimulation|amod|END_ENTITY	Calcium influx and intracellular stores in angiotensin_II stimulation of normal and hyperplastic pituitary cells .
1424216	0	Calcium	0,7	angiotensin_II	27,41	Calcium	angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	Calcium suppresses central angiotensin_II pressor response less in SHR .
3241206	0	Calcium	0,7	angiotensin_II	102,116	Calcium	angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	efflux|amod|START_ENTITY efflux|dep|effect effect|nmod|END_ENTITY	Calcium efflux in cultured vascular smooth muscle cells from genetically hypertensive rats : effect of angiotensin_II and vasopressin .
3399509	0	Calcium	0,7	angiotensin_II	71,85	Calcium	angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	oscillations|nsubj|START_ENTITY oscillations|nmod|cells cells|acl|stimulated stimulated|nmod|END_ENTITY	Calcium oscillations in single adrenal glomerulosa cells stimulated by angiotensin_II .
7318359	0	Calcium	0,7	angiotensin_II	68,82	Calcium	angiotensin II	MESH:D002118	183	Chemical	Gene	antagonists|amod|START_ENTITY decrease|nsubj|antagonists decrease|nmod|END_ENTITY	Calcium antagonists decrease adrenal and vascular responsiveness to angiotensin_II in normal man .
9776731	0	Calcium	0,7	angiotensin_II	82,96	Calcium	angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	activation|amod|START_ENTITY kinase|nsubj|activation kinase|nmod|END_ENTITY	Calcium - and protein_kinase_C-dependent activation of the tyrosine kinase PYK2 by angiotensin_II in vascular smooth muscle .
7947730	0	Calcium	0,7	annexin_II	68,78	Calcium	annexin II	MESH:D002118	302	Chemical	Gene	properties|amod|START_ENTITY properties|nmod|END_ENTITY	Calcium and membrane-binding properties of monomeric and multimeric annexin_II .
1675590	0	Calcium	0,7	atrial_natriuretic_factor	72,97	Calcium	atrial natriuretic factor	MESH:D002118	24602(Tax:10116)	Chemical	Gene	reveals|nsubj|START_ENTITY reveals|dobj|mechanisms mechanisms|nmod|activation activation|nmod|END_ENTITY	Calcium reveals different mechanisms of guanylate cyclase activation by atrial_natriuretic_factor and ATP in rat lung membranes .
2158988	0	Calcium	0,7	atrial_natriuretic_factor	85,110	Calcium	atrial natriuretic factor	MESH:D002118	24602(Tax:10116)	Chemical	Gene	dependence|amod|START_ENTITY dependence|nmod|END_ENTITY	Calcium dependence of phenylephrine - , endothelin - , and potassium_chloride-stimulated atrial_natriuretic_factor secretion from long term primary neonatal rat atrial cardiocytes .
2525528	0	Calcium	0,7	atrial_natriuretic_factor	34,59	Calcium	atrial natriuretic factor	MESH:D002118	24602(Tax:10116)	Chemical	Gene	infusion|amod|START_ENTITY increases|nsubj|infusion increases|dobj|END_ENTITY	Calcium infusion increases plasma atrial_natriuretic_factor in spontaneously hypertensive rats .
1902674	0	Calcium	0,7	bradykinin	31,41	Calcium	bradykinin	MESH:D002118	3827	Chemical	Gene	oscillation|amod|START_ENTITY oscillation|acl|induced induced|nmod|END_ENTITY	Calcium oscillation induced by bradykinin in polyoma middle T antigen-transformed NIH3T3 fibroblasts : evidence for dependence on protein_kinase_C .
8185639	0	Calcium	0,7	bradykinin	72,82	Calcium	bradykinin	MESH:D002118	280833(Tax:9913)	Chemical	Gene	efflux|amod|START_ENTITY induced|nsubj|efflux induced|nmod|END_ENTITY	Calcium efflux from cultured bovine adrenal chromaffin cells induced by bradykinin .
8396347	0	Calcium	0,7	bradykinin	91,101	Calcium	bradykinin	MESH:D002118	3827	Chemical	Gene	START_ENTITY|nmod|endothelium endothelium|acl|exposed exposed|nmod|END_ENTITY	Calcium entry , mobilization , and extrusion in postcapillary venular endothelium exposed to bradykinin .
2176707	0	Calcium	0,7	calbindin-D28k	25,39	Calcium	calbindin-D28k	MESH:D002118	12307(Tax:10090)	Chemical	Gene	protein|compound|START_ENTITY protein|dep|END_ENTITY	Calcium binding protein -LRB- calbindin-D28k -RRB- gene expression in the developing and aging mouse cerebellum .
7428674	0	Calcium	0,7	calcitonin	44,54	Calcium	calcitonin	MESH:D002118	24241(Tax:10116)	Chemical	Gene	action|amod|START_ENTITY action|nmod|END_ENTITY	Calcium regulatory action of endogenous rat calcitonin demonstrated by passive immunization with calcitonin antibodies .
7428674	0	Calcium	0,7	calcitonin	97,107	Calcium	calcitonin	MESH:D002118	24241(Tax:10116)	Chemical	Gene	action|amod|START_ENTITY demonstrated|nsubj|action demonstrated|nmod|antibodies antibodies|compound|END_ENTITY	Calcium regulatory action of endogenous rat calcitonin demonstrated by passive immunization with calcitonin antibodies .
17466291	0	Calcium	0,7	calcium-sensing_receptor	46,70	Calcium	calcium-sensing receptor	MESH:D002118	24247(Tax:10116)	Chemical	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	Calcium acts as a first messenger through the calcium-sensing_receptor in the cardiovascular system .
21472691	0	Calcium	0,7	calcium-sensing_receptor	9,33	Calcium	calcium-sensing receptor	MESH:D002118	846	Chemical	Gene	control|advmod|START_ENTITY control|nsubj|END_ENTITY	Calcium , calcium-sensing_receptor and growth control in the colonic_mucosa .
26407952	0	Calcium	0,7	calcium-sensing_receptor	37,61	Calcium	calcium-sensing receptor	MESH:D002118	846	Chemical	Gene	intake|amod|START_ENTITY intake|appos|polymorphisms polymorphisms|nmod|END_ENTITY	Calcium intake , polymorphisms of the calcium-sensing_receptor , and recurrent/aggressive _ prostate_cancer .
9860089	0	Calcium	0,7	calcyphosine	24,36	Calcium	calcyphosine	MESH:D002118	403965(Tax:9615)	Chemical	Gene	protein|amod|START_ENTITY END_ENTITY|nsubj|protein	Calcium binding protein calcyphosine in dog central astrocytes and ependymal cells and in peripheral neurons .
12207244	0	Calcium	0,7	calmodulin	76,86	Calcium	calmodulin	MESH:D002118	808	Chemical	Gene	detection|amod|START_ENTITY liposomes|nsubj|detection liposomes|xcomp|containing containing|dobj|END_ENTITY	Calcium ion fluorescence detection using liposomes containing Alexa-labeled calmodulin .
12414709	0	Calcium	0,7	calmodulin	19,29	Calcium	calmodulin	MESH:D002118	808	Chemical	Gene	mutants|amod|START_ENTITY mutants|amod|binding binding|nmod|END_ENTITY	Calcium binding to calmodulin mutants monitored by domain-specific intrinsic phenylalanine and tyrosine fluorescence .
15917089	0	Calcium	0,7	calmodulin	78,88	Calcium	calmodulin	MESH:D002118	808	Chemical	Gene	affinity|compound|START_ENTITY affinity|nmod|domain domain|nmod|END_ENTITY	Calcium and lanthanide affinity of the EF-loops from the C-terminal domain of calmodulin .
17713923	0	Calcium	0,7	calmodulin	45,55	Calcium	calmodulin	MESH:D002118	808	Chemical	Gene	occupancy|amod|START_ENTITY occupancy|nmod|sites sites|nmod|END_ENTITY	Calcium occupancy of N-terminal sites within calmodulin induces inhibition of the ryanodine_receptor calcium release channel .
18353974	0	Calcium	0,7	calmodulin	49,59	Calcium	calmodulin	MESH:D002118	808	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|compound|END_ENTITY	Calcium regulation of myogenesis by differential calmodulin inhibition of basic helix-loop-helix transcription factors .
19133300	0	Calcium	0,7	calmodulin	32,42	Calcium	calmodulin	MESH:D002118	808	Chemical	Gene	fingerprints|amod|START_ENTITY induced|nsubj|fingerprints induced|nmod|interactors interactors|compound|END_ENTITY	Calcium fingerprints induced by calmodulin interactors in eukaryotic cells .
7632797	0	Calcium	0,7	calmodulin	76,86	Calcium	calmodulin	MESH:D002118	808	Chemical	Gene	START_ENTITY|xcomp|responsive responsive|dep|assembling assembling|nmod|END_ENTITY	Calcium responsive two-dimensional molecular assembling of lipid-conjugated calmodulin .
8485471	0	Calcium	0,7	calmodulin	32,42	Calcium	calmodulin	MESH:D002118	36329(Tax:7227)	Chemical	Gene	mutants|amod|START_ENTITY mutants|nmod|END_ENTITY	Calcium binding site mutants of calmodulin adopt abnormal conformations in complexes with model target peptides .
9315874	0	Calcium	0,7	calmodulin	25,35	Calcium	calmodulin	MESH:D002118	36329(Tax:7227)	Chemical	Gene	sites|amod|START_ENTITY sites|nmod|END_ENTITY	Calcium binding sites of calmodulin and electron transfer by neuronal nitric_oxide synthase .
8053	0	Calcium	0,7	catechol-O-methyltransferase	32,60	Calcium	catechol-O-methyltransferase	MESH:D002118	24267(Tax:10116)	Chemical	Gene	inhibition|amod|START_ENTITY END_ENTITY|nsubj|inhibition	Calcium inhibition of rat liver catechol-O-methyltransferase .
15654740	0	Calcium	0,7	centrin_3	39,48	Calcium	centrin 3	MESH:D002118	1070	Chemical	Gene	binding|nsubj|START_ENTITY binding|nmod|END_ENTITY	Calcium and magnesium binding to human centrin_3 and interaction with target peptides .
2495735	0	Calcium	0,7	cholecystokinin	28,43	Calcium	cholecystokinin	MESH:D002118	885	Chemical	Gene	sources|amod|START_ENTITY utilized|nsubj|sources utilized|nmod|END_ENTITY	Calcium sources utilized by cholecystokinin and acetylcholine in the cat gallbladder muscle .
8048482	0	Calcium	0,7	cholecystokinin	19,34	Calcium	cholecystokinin	MESH:D002118	25298(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY release|nmod|OPE OPE|amod|END_ENTITY	Calcium release by cholecystokinin analogue OPE is IP3 dependent in single rat pancreatic acinar cells .
20807759	0	Calcium	0,7	claudin-2	57,66	Calcium	claudin-2	MESH:D002118	403649(Tax:9615)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Calcium inhibits paracellular sodium conductance through claudin-2 by competitive binding .
7980531	0	Calcium	0,7	cyclin_D1	22,31	Calcium	cyclin D1	MESH:D002118	58919(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	Calcium modulates the cyclin_D1 expression in a rat parathyroid cell line .
10455298	0	Calcium	0,7	cyclooxygenase-2	39,55	Calcium	cyclooxygenase-2	MESH:D002118	5743	Chemical	Gene	properties|amod|START_ENTITY properties|nmod|inhibitor inhibitor|amod|END_ENTITY	Calcium antagonistic properties of the cyclooxygenase-2 inhibitor nimesulide in human myometrial myocytes .
11040104	0	Calcium	0,7	endothelin-1	29,41	Calcium	endothelin-1	MESH:D002118	24323(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|handling handling|nmod|END_ENTITY	Calcium handling and role of endothelin-1 in monocrotaline right_ventricular_hypertrophy of the rat .
15358810	0	Calcium	0,7	endothelin-1	30,42	Calcium	endothelin-1	MESH:D002118	1906	Chemical	Gene	channels|amod|START_ENTITY activated|nsubj|channels activated|nmod|END_ENTITY	Calcium channels activated by endothelin-1 in human trophoblast .
17553940	0	Calcium	0,7	endothelin-1	22,34	Calcium	endothelin-1	MESH:D002118	24323(Tax:10116)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|synthesis synthesis|amod|END_ENTITY	Calcium regulation of endothelin-1 synthesis in rat inner medullary collecting duct .
7509995	0	Calcium	0,7	endothelin-1	42,54	Calcium	endothelin-1	MESH:D002118	1906	Chemical	Gene	ionophores|amod|START_ENTITY inhibit|nsubj|ionophores inhibit|dobj|release release|nmod|END_ENTITY	Calcium ionophores inhibit the release of endothelin-1 from endothelial cells .
8830303	0	Calcium	0,7	enkephalin	104,114	Calcium	enkephalin	MESH:D002118	29237(Tax:10116)	Chemical	Gene	influx|amod|START_ENTITY inhibited|nsubjpass|influx inhibited|nmod|END_ENTITY	Calcium influx in rat thalamic relay neurons through voltage-dependent calcium channels is inhibited by enkephalin .
8099784	0	Calcium	0,7	epidermal_growth_factor	45,68	Calcium	epidermal growth factor	MESH:D002118	1950	Chemical	Gene	pretreatment|compound|START_ENTITY induces|nsubj|pretreatment induces|xcomp|binding binding|nsubj|decrease decrease|nmod|END_ENTITY	Calcium pretreatment induces the decrease in epidermal_growth_factor binding through the activation of transglutaminase in isolated liver membrane .
20937240	0	Calcium	0,7	erythropoietin	30,44	Calcium	erythropoietin	MESH:D002118	2056	Chemical	Gene	START_ENTITY|nmod|mediator mediator|nmod|END_ENTITY	Calcium as a mediator between erythropoietin and protein_tyrosine_phosphatase_1B .
7929395	0	Calcium	0,7	fibrillin-1	107,118	Calcium	fibrillin-1	MESH:D002118	2200	Chemical	Gene	binding|compound|START_ENTITY binding|dep|domains domains|nmod|END_ENTITY	Calcium binding , hydroxylation , and glycosylation of the precursor epidermal growth factor-like domains of fibrillin-1 , the Marfan gene protein .
8568869	0	Calcium	0,7	fibrillin-1	85,96	Calcium	fibrillin-1	MESH:D002118	2200	Chemical	Gene	properties|amod|START_ENTITY factor-like|nsubj|properties factor-like|nmod|END_ENTITY	Calcium binding properties of an epidermal growth factor-like domain pair from human fibrillin-1 .
8995426	0	Calcium	0,7	fibrillin-1	19,30	Calcium	fibrillin-1	MESH:D002118	2200	Chemical	Gene	stabilizes|nsubj|START_ENTITY stabilizes|xcomp|END_ENTITY	Calcium stabilizes fibrillin-1 against proteolytic_degradation .
7079591	0	Calcium	0,7	gastrin	107,114	Calcium	gastrin	MESH:D002118	25320(Tax:10116)	Chemical	Gene	absorption|amod|START_ENTITY influenced|nsubj|absorption influenced|nmod|END_ENTITY	Calcium absorption in the rat as influenced by highly selective vagotomy with special regard to endogenous gastrin .
873325	0	Calcium	0,7	gastrin	23,30	Calcium	gastrin	MESH:D002118	2520	Chemical	Gene	stimulation|amod|START_ENTITY stimulation|nmod|secretion secretion|compound|END_ENTITY	Calcium stimulation of gastrin and gastric_acid secretion : effect of small doses of calcium_carbonate .
10819996	0	Calcium	0,7	gelsolin	22,30	Calcium	gelsolin	MESH:D002118	2934	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Calcium regulation of gelsolin and adseverin : a natural test of the helix latch hypothesis .
16466744	0	Calcium	0,7	gelsolin	36,44	Calcium	gelsolin	MESH:D002118	2934	Chemical	Gene	ion|compound|START_ENTITY exchange|nsubj|ion exchange|nmod|END_ENTITY	Calcium ion exchange in crystalline gelsolin .
1326758	0	Calcium	0,7	gonadotropin-releasing_hormone	44,74	Calcium	gonadotropin-releasing hormone	MESH:D002118	25194(Tax:10116)	Chemical	Gene	signaling|nmod:npmod|START_ENTITY signaling|nmod|END_ENTITY	Calcium signaling and episodic secretion of gonadotropin-releasing_hormone in hypothalamic neurons .
20594958	0	Calcium	0,7	gonadotropin-releasing_hormone	20,50	Calcium	gonadotropin-releasing hormone	MESH:D002118	2796	Chemical	Gene	dynamics|amod|START_ENTITY dynamics|nmod|neurons neurons|amod|END_ENTITY	Calcium dynamics in gonadotropin-releasing_hormone neurons .
1505473	0	Calcium	0,7	growth_hormone	23,37	Calcium	growth hormone	MESH:D002118	2688	Chemical	Gene	homeostasis|amod|START_ENTITY homeostasis|nmod|END_ENTITY	Calcium homeostasis in growth_hormone -LRB- GH -RRB- - secreting adenoma cells : effect of GH-releasing factor .
3932123	0	Calcium	0,7	growth_hormone	19,33	Calcium	growth hormone	MESH:D002118	378781(Tax:9031)	Chemical	Gene	control|amod|START_ENTITY control|nmod|release release|amod|END_ENTITY	Calcium control of growth_hormone release from chicken pituitary glands in vitro .
12390029	0	Calcium	0,7	guanylate_cyclase-activating_protein-1	47,85	Calcium	guanylate cyclase-activating protein-1	MESH:D002118	2980	Chemical	Gene	properties|amod|START_ENTITY properties|amod|END_ENTITY	Calcium - and myristoyl-dependent properties of guanylate_cyclase-activating_protein-1 and protein-2 .
10825153	0	Calcium	0,7	histone_deacetylase_4	77,98	Calcium	histone deacetylase 4	MESH:D002118	9759	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Calcium regulates transcriptional repression of myocyte_enhancer_factor_2 by histone_deacetylase_4 .
1727048	0	Calcium	0,7	insulin	59,66	Calcium	insulin	MESH:D002118	3630	Chemical	Gene	ions|amod|START_ENTITY required|nsubjpass|ions required|nmod|intracellular intracellular|acl|routing routing|nmod|END_ENTITY	Calcium ions are required for the intracellular routing of insulin and its receptor .
3081574	0	Calcium	0,7	insulin	58,65	Calcium	insulin	MESH:D002118	3630	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Calcium dependency and free calcium concentrations during insulin secretion in a hamster beta cell line .
8813473	0	Calcium	0,7	insulin	42,49	Calcium	insulin	MESH:D002118	3630	Chemical	Gene	reverses|nsubj|START_ENTITY reverses|dobj|inhibition inhibition|nmod|levels levels|compound|END_ENTITY	Calcium reverses octreotide inhibition of insulin and glucagon levels in patients with insulinoma and glucagonoma .
15005855	0	Calcium	0,7	interleukin-8	58,71	Calcium	interleukin-8	MESH:D002118	3576	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Calcium signaling pathway involving calcineurin regulates interleukin-8 gene expression through activation of NF-kappaB in human osteoblast-like cells .
8319811	0	Calcium	0,7	interleukin-8	33,46	Calcium	interleukin-8	MESH:D002118	3576	Chemical	Gene	A23187|compound|START_ENTITY induces|nsubj|A23187 induces|dobj|expression expression|amod|END_ENTITY	Calcium ionophore A23187 induces interleukin-8 gene expression and protein secretion in human monocytic cells .
1645732	9	Calcium	1538,1545	lysophospholipase	1567,1584	Calcium	lysophospholipase	MESH:D002118	5321	Chemical	Gene	required|nsubjpass|START_ENTITY required|nmod|activity activity|amod|END_ENTITY	Calcium was not required for lysophospholipase activity , in contrast to phospholipase_A2 activity .
11483652	0	Calcium	0,7	mPer1	106,111	Calcium	mPer1	MESH:D002118	18626(Tax:10090)	Chemical	Gene	induced|nsubj|START_ENTITY induced|dobj|expression expression|nmod|END_ENTITY	Calcium and pituitary adenylate cyclase-activating polypeptide induced expression of circadian clock gene mPer1 in the mouse cerebellar granule cell culture .
10205303	0	Calcium	0,7	myosin	93,99	Calcium	myosin	MESH:D002118	79784	Chemical	Gene	ions|amod|START_ENTITY modulate|nsubj|ions modulate|dobj|regulation regulation|nmod|contraction contraction|acl|mediated mediated|nmod|phosphorylation phosphorylation|nmod|chains chains|amod|END_ENTITY	Calcium ions modulate regulation of smooth muscle contraction mediated by phosphorylation of myosin regulatory light chains .
113400	0	Calcium	0,7	myosin	122,128	Calcium	myosin	MESH:D002118	417310(Tax:9031)	Chemical	Gene	regulation|amod|START_ENTITY gizzard|nsubj|regulation gizzard|dobj|superprecipitation superprecipitation|nmod|END_ENTITY	Calcium regulation in chicken gizzard muscle and inosine_triphosphate-induced superprecipitation of skeletal acto-gizzard myosin .
129988	0	Calcium	0,7	myosin	78,84	Calcium	myosin	MESH:D002118	79784	Chemical	Gene	sensitivity|amod|START_ENTITY sensitivity|dep|modification modification|nmod|substitution substitution|nmod|groups groups|amod|END_ENTITY	Calcium sensitivity of actomyosin ATPase : its modification by substitution of myosin sulfhydryl groups .
16404592	0	Calcium	0,7	myosin	45,51	Calcium	myosin	MESH:D002118	79784	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|advcl|changing changing|dobj|flexibility flexibility|compound|END_ENTITY	Calcium regulates scallop muscle by changing myosin flexibility .
3024616	0	Calcium	0,7	myosin	65,71	Calcium	myosin	MESH:D002118	79784	Chemical	Gene	sensitivity|amod|START_ENTITY sensitivity|dep|effect effect|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Calcium sensitivity of myofilaments in cardiac muscle -- effect of myosin phosphorylation .
3156278	0	Calcium	0,7	myosin	32,38	Calcium	myosin	MESH:D002118	79784	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Calcium regulation of molluscan myosin ATPase in the absence of actin .
3170551	0	Calcium	0,7	myosin	22,28	Calcium	myosin	MESH:D002118	79784	Chemical	Gene	dependence|amod|START_ENTITY dependence|nmod|chain chain|amod|END_ENTITY	Calcium dependence of myosin light chain phosphorylation in smooth muscle cells .
3963173	0	Calcium	0,7	myosin	22,28	Calcium	myosin	MESH:D002118	79784	Chemical	Gene	START_ENTITY|dobj|dependence dependence|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Calcium dependence of myosin phosphorylation and airway smooth muscle contraction and relaxation .
8113759	0	Calcium	0,7	neuraminidase	63,76	Calcium	neuraminidase	MESH:D002118	4758	Chemical	Gene	needed|nsubjpass|START_ENTITY needed|nmod|thermostability thermostability|nmod|END_ENTITY	Calcium is needed for the thermostability of influenza_B_virus neuraminidase .
2887481	0	Calcium	0,7	neurotensin	22,33	Calcium	neurotensin	MESH:D002118	100354423(Tax:9986)	Chemical	Gene	dependence|amod|START_ENTITY dependence|nmod|stimulation stimulation|compound|END_ENTITY	Calcium dependence of neurotensin stimulation of circular colonic muscle of the rabbit .
9070744	0	Calcium	0,7	neurotrophin-3	97,111	Calcium	neurotrophin-3	MESH:D002118	428099(Tax:9031)	Chemical	Gene	currents|amod|START_ENTITY neurons|nsubj|currents neurons|advcl|END_ENTITY	Calcium currents in dissociated cochlear neurons from the chick embryo and their modification by neurotrophin-3 .
6690450	0	Calcium	0,7	ornithine_decarboxylase	19,42	Calcium	ornithine decarboxylase	MESH:D002118	4953	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|amod|END_ENTITY	Calcium stimulates ornithine_decarboxylase activity in cultured mammalian epithelial cells .
7935423	0	Calcium	0,7	p21ras	63,69	Calcium	p21ras	MESH:D002118	3265	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	Calcium inhibits epidermal growth factor-induced activation of p21ras in human primary keratinocytes .
18160068	0	Calcium	0,7	parathyroid_hormone	52,71	Calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	homeostasis|amod|START_ENTITY homeostasis|dep|reassessment reassessment|nmod|actions actions|nmod|END_ENTITY	Calcium homeostasis : reassessment of the actions of parathyroid_hormone .
20171720	0	Calcium	0,7	parathyroid_hormone	9,28	Calcium	parathyroid hormone	MESH:D002118	280903(Tax:9913)	Chemical	Gene	START_ENTITY|appos|profiles profiles|compound|END_ENTITY	Calcium , parathyroid_hormone , oxytocin and pH profiles in the whelping bitch .
2203847	0	Calcium	0,7	parathyroid_hormone	37,56	Calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	supplementation|amod|START_ENTITY lowers|nsubj|supplementation lowers|dobj|levels levels|compound|END_ENTITY	Calcium supplementation lowers serum parathyroid_hormone levels in elderly subjects .
2509026	0	Calcium	0,7	parathyroid_hormone	37,56	Calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|ccomp|enhance enhance|dobj|cells cells|amod|END_ENTITY	Calcium and protein kinase C enhance parathyroid_hormone - and forskolin-stimulated adenylate cyclase in ROS 17/2 .8 cells .
25118085	0	Calcium	0,7	parathyroid_hormone	48,67	Calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	maintains|nsubj|START_ENTITY maintains|dobj|END_ENTITY	Calcium and vitamin_D supplementation maintains parathyroid_hormone and improves bone density during initial military training : A randomized , double-blind , placebo controlled trial .
3926281	0	Calcium	0,7	parathyroid_hormone	35,54	Calcium	parathyroid hormone	MESH:D002118	396436(Tax:9031)	Chemical	Gene	homeostasis|amod|START_ENTITY homeostasis|dep|effect effect|nmod|difference difference|amod|END_ENTITY	Calcium homeostasis : the effect of parathyroid_hormone on bone membrane electrical potential difference .
494968	0	Calcium	0,7	parathyroid_hormone	62,81	Calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	infusion|amod|START_ENTITY infusion|dep|changes changes|nmod|concentration concentration|amod|END_ENTITY	Calcium infusion in suspected hyperparathyroidism : changes in parathyroid_hormone concentration related to histopathological findings .
9458921	0	Calcium	0,7	parathyroid_hormone	37,56	Calcium	parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	intake|amod|START_ENTITY intake|dep|influence influence|nmod|END_ENTITY	Calcium intake by rats : influence of parathyroid_hormone , calcitonin , and 1,25-dihydroxyvitamin _ D .
10802529	0	Calcium	0,7	parathyroid_hormone-related_protein	19,54	Calcium	parathyroid hormone-related protein	MESH:D002118	24695(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|amod|END_ENTITY	Calcium stimulates parathyroid_hormone-related_protein production in Leydig tumor cells through a putative cation-sensing mechanism .
16303159	0	Calcium	0,7	phospholipase_A2	71,87	Calcium	phospholipase A2	MESH:D002118	151056	Chemical	Gene	plays|advmod|START_ENTITY plays|dep|END_ENTITY	Calcium plays a key role in the effects induced by a snake venom Lys49 phospholipase_A2 homologue on a lymphoblastoid cell line .
6477872	0	Calcium	0,7	phospholipase_A2	34,50	Calcium	phospholipase A2	MESH:D002118	151056	Chemical	Gene	ion|nsubj|START_ENTITY ion|xcomp|binding binding|nmod|END_ENTITY	Calcium ion binding to pancreatic phospholipase_A2 and its zymogen : a 43Ca NMR study .
8192898	0	Calcium	0,7	phospholipase_A2	92,108	Calcium	phospholipase A2	MESH:D002118	151056	Chemical	Gene	ions|nsubj|START_ENTITY ions|xcomp|reverse reverse|dobj|period period|acl|induced induced|nmod|albumin albumin|nmod|course course|nmod|action action|amod|END_ENTITY	Calcium ions reverse a latency period induced by bovine serum albumin in the time course of phospholipase_A2 action on 1,2-dipalmitoyl-sn-glycero-3-phosphocholine liposomes .
17369432	0	Calcium	0,7	phospholipase_C	22,37	Calcium	phospholipase C	MESH:D002118	835981(Tax:3702)	Chemical	Gene	signaling|compound|START_ENTITY signaling|nmod|END_ENTITY	Calcium signaling via phospholipase_C is essential for proline accumulation upon ionic but not nonionic hyperosmotic stresses in Arabidopsis .
12193569	0	Calcium	0,7	prolactin	64,73	Calcium	prolactin	MESH:D002118	5617	Chemical	Gene	dynamics|amod|START_ENTITY regulates|nsubj|dynamics regulates|dobj|expression expression|amod|END_ENTITY	Calcium dynamics and resting transcriptional activity regulates prolactin gene expression .
18411139	0	Calcium	0,7	prolactin	37,46	Calcium	prolactin	MESH:D002118	5617	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Calcium and calmodulin regulation of prolactin gene expression .
2514348	0	Calcium	0,7	prolactin	22,31	Calcium	prolactin	MESH:D002118	24683(Tax:10116)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Calcium regulation of prolactin gene expression : opposing effects of extracellular CaCl2 and Ca2 + ionophores .
3151248	0	Calcium	0,7	prolactin	22,31	Calcium	prolactin	MESH:D002118	24683(Tax:10116)	Chemical	Gene	dependence|amod|START_ENTITY dependence|nmod|accumulation accumulation|amod|END_ENTITY	Calcium dependence of prolactin mRNA accumulation in GH3 rat pituitary_tumour cells .
3159606	0	Calcium	0,7	prolactin	33,42	Calcium	prolactin	MESH:D002118	5617	Chemical	Gene	release|amod|START_ENTITY release|compound|END_ENTITY	Calcium mobilization potentiates prolactin release induced by protein kinase C activators .
5353031	0	Calcium	0,7	prolactin	28,37	Calcium	prolactin	MESH:D002118	24683(Tax:10116)	Chemical	Gene	requirement|amod|START_ENTITY requirement|nmod|END_ENTITY	Calcium ion requirement for prolactin secretion by rat adenohypophyses in vitro .
6250393	0	Calcium	0,7	prolactin	158,167	Calcium	prolactin	MESH:D002118	5617	Chemical	Gene	START_ENTITY|dep|study study|nmod|secretion secretion|compound|END_ENTITY	Calcium and the secretory cycle of prolactin cells : a cytochemical and ultrastructural study of dopamine inhibition and monobutyryl_cyclic_AMP-stimulation of prolactin secretion .
1878334	0	Calcium	0,7	renin	62,67	Calcium	renin	MESH:D002118	100524822	Chemical	Gene	blocker|amod|START_ENTITY prevents|nsubj|blocker prevents|dobj|activation activation|nmod|END_ENTITY	Calcium channel blocker prevents stress-induced activation of renin and aldosterone in conscious pig .
3533639	0	Calcium	0,7	renin	70,75	Calcium	renin	MESH:D002118	5972	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|dep|relationship relationship|nmod|activity activity|compound|END_ENTITY	Calcium metabolism in essential hypertension : relationship to altered renin system activity .
4362948	0	Calcium	0,7	renin	62,67	Calcium	renin	MESH:D002118	24715(Tax:10116)	Chemical	Gene	dependence|amod|START_ENTITY dependence|nmod|secretion secretion|compound|END_ENTITY	Calcium dependence of the inhibitory effect of angiotensin on renin secretion in the isolated perfused kidney of the rat .
6750722	0	Calcium	0,7	renin	60,65	Calcium	renin	MESH:D002118	24715(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY release|dep|inhibition inhibition|nmod|secretion secretion|compound|END_ENTITY	Calcium and renin release : inhibition of low sodium-induced renin secretion by high calcium concentration in rat kidney perfusion .
7006417	0	Calcium	0,7	renin	26,31	Calcium	renin	MESH:D002118	5972	Chemical	Gene	START_ENTITY|nmod|control control|nmod|secretion secretion|compound|END_ENTITY	Calcium in the control of renin secretion : Ca2 + influx as an inhibitory signal .
7031229	0	Calcium	0,7	renin	80,85	Calcium	renin	MESH:D002118	24715(Tax:10116)	Chemical	Gene	dependency|compound|START_ENTITY dependency|nmod|effect effect|nmod|hormone hormone|nmod|END_ENTITY	Calcium dependency of the inhibitory effect of antidiuretic hormone on in vitro renin secretion in rats .
98060	0	Calcium	0,7	renin	26,31	Calcium	renin	MESH:D002118	100524822	Chemical	Gene	START_ENTITY|nmod|control control|nmod|release release|compound|END_ENTITY	Calcium in the control of renin release .
17713923	0	Calcium	0,7	ryanodine_receptor	82,100	Calcium	ryanodine receptor	MESH:D002118	6261	Chemical	Gene	occupancy|amod|START_ENTITY induces|nsubj|occupancy induces|dobj|inhibition inhibition|nmod|channel channel|compound|END_ENTITY	Calcium occupancy of N-terminal sites within calmodulin induces inhibition of the ryanodine_receptor calcium release channel .
23131566	0	Calcium	0,7	ryanodine_receptor	21,39	Calcium	ryanodine receptor	MESH:D002118	20190(Tax:10090)	Chemical	Gene	leak|amod|START_ENTITY leak|nmod|END_ENTITY	Calcium leak through ryanodine_receptor is involved in neuronal_death induced by mutant huntingtin .
9199492	0	Calcium	0,7	sorcin	42,48	Calcium	sorcin	MESH:D002118	6717	Chemical	Gene	oligomerization|amod|START_ENTITY oligomerization|nmod|END_ENTITY	Calcium - and pH-linked oligomerization of sorcin causing translocation from cytosol to membranes .
11959652	0	Calcium	0,7	substance_P	59,70	Calcium	substance P	MESH:D002118	6863	Chemical	Gene	action|amod|START_ENTITY action|nmod|END_ENTITY	Calcium - and superoxide anion-mediated mitogenic action of substance_P on cardiac fibroblasts .
2542947	0	Calcium	0,7	synexin	43,50	Calcium	synexin	MESH:D002118	310	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Calcium channel activity of purified human synexin and structure of the human synexin gene .
6224488	0	Calcium	0,7	synexin	37,44	Calcium	synexin	MESH:D002118	310	Chemical	Gene	dependence|amod|START_ENTITY dependence|nmod|END_ENTITY	Calcium dependence of the binding of synexin to isolated chromaffin granules .
2765562	0	Calcium	0,7	thioredoxin_reductase	18,39	Calcium	thioredoxin reductase	MESH:D002118	25824	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Calcium regulates thioredoxin_reductase in human metastatic_melanoma .
10568828	5	Calcium	557,564	thrombin	623,631	Calcium	thrombin	MESH:D002118	2147	Chemical	Gene	influx|amod|START_ENTITY increased|nsubjpass|influx increased|nmod|END_ENTITY	Calcium influx was significantly increased after stimulation with thrombin and prothrombin .
2937786	0	Calcium	0,7	thrombin	47,55	Calcium	thrombin	MESH:D002118	280685(Tax:9913)	Chemical	Gene	binding|compound|START_ENTITY binding|nmod|cleavage cleavage|compound|END_ENTITY	Calcium binding of bovine protein S. Effect of thrombin cleavage and removal of the gamma-carboxyglutamic_acid-containing region .
6625618	0	Calcium	0,7	thrombin	133,141	Calcium	thrombin	MESH:D002118	2147	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|decreasing decreasing|dobj|affinity affinity|nmod|heparin heparin|nmod|END_ENTITY	Calcium inhibits the heparin-catalyzed antithrombin III/thrombin reaction by decreasing the apparent binding affinity of heparin for thrombin .
8055928	0	Calcium	0,7	thrombin	53,61	Calcium	thrombin	MESH:D002118	2147	Chemical	Gene	inhibition|amod|START_ENTITY C|nsubj|inhibition C|nmod|END_ENTITY	Calcium inhibition of the activation of protein C by thrombin .
9589368	0	Calcium	0,7	thrombin	68,76	Calcium	thrombin	MESH:D002118	2147	Chemical	Gene	mobilization|amod|START_ENTITY cleavage|nsubj|mobilization cleavage|nmod|stimulation stimulation|compound|END_ENTITY	Calcium mobilization and protease-activated receptor cleavage after thrombin stimulation in motor neurons .
9636055	0	Calcium	0,7	thrombomodulin	80,94	Calcium	thrombomodulin	MESH:D002118	7056	Chemical	Gene	properties|amod|START_ENTITY factor-like|nsubj|properties factor-like|nmod|END_ENTITY	Calcium binding properties of an epidermal growth factor-like domain from human thrombomodulin .
7829507	0	Calcium	0,7	thrombospondin_1	23,39	Calcium	thrombospondin 1	MESH:D002118	7057	Chemical	Gene	ion|nsubj|START_ENTITY ion|xcomp|binding binding|nmod|END_ENTITY	Calcium ion binding to thrombospondin_1 .
1794608	0	Calcium	0,7	thyroglobulin	32,45	Calcium	thyroglobulin	MESH:D002118	280706(Tax:9913)	Chemical	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	Calcium interaction with bovine thyroglobulin : stoichiometry and structural consequences of calcium binding .
11145744	0	Calcium	0,7	thyrotropin-releasing_hormone	21,50	Calcium	thyrotropin-releasing hormone	MESH:D002118	22044(Tax:10090)	Chemical	Gene	responses|amod|START_ENTITY responses|nmod|END_ENTITY	Calcium responses to thyrotropin-releasing_hormone , gonadotropin-releasing_hormone and somatostatin in phospholipase css3 knockout mice .
6409414	0	Calcium	0,7	thyrotropin-releasing_hormone	35,64	Calcium	thyrotropin-releasing hormone	MESH:D002118	25569(Tax:10116)	Chemical	Gene	influx|amod|START_ENTITY required|nsubjpass|influx required|nmod|stimulation stimulation|amod|END_ENTITY	Calcium influx is not required for thyrotropin-releasing_hormone stimulation of prolactin release from GH3 cells .
6790560	0	Calcium	0,7	thyrotropin-releasing_hormone	86,115	Calcium	thyrotropin-releasing hormone	MESH:D002118	7200	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|END_ENTITY	Calcium and calcium-antagonistic effects on prolactin and growth_hormone responses to thyrotropin-releasing_hormone and L-dopa in man .
6798509	0	Calcium	0,7	thyrotropin-releasing_hormone	43,72	Calcium	thyrotropin-releasing hormone	MESH:D002118	25569(Tax:10116)	Chemical	Gene	dependency|compound|START_ENTITY dependency|nmod|secretion secretion|amod|END_ENTITY	Calcium dependency of potassium-stimulated thyrotropin-releasing_hormone secretion from rat neurohypophysis in vitro .
9060995	0	Calcium	0,7	tissue-type_plasminogen_activator	34,67	Calcium	tissue-type plasminogen activator	MESH:D002118	5327	Chemical	Gene	spirulan|amod|START_ENTITY spirulan|nmod|inducer inducer|nmod|END_ENTITY	Calcium spirulan as an inducer of tissue-type_plasminogen_activator in human fetal lung fibroblasts .
8029817	0	Calcium	0,7	tissue_plasminogen_activator	22,50	Calcium	tissue plasminogen activator	MESH:D002118	100128998	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|release release|compound|END_ENTITY	Calcium regulation of tissue_plasminogen_activator and plasminogen_activator_inhibitor-1 release from cultured human vascular endothelial cells .
15946660	0	Calcium	0,7	tissue_transglutaminase	22,45	Calcium	tissue transglutaminase	MESH:D002118	7052	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Calcium activation of tissue_transglutaminase in radioligand binding and enzyme-linked autoantibody immunoassays in childhood celiac_disease .
15662726	0	Calcium	0,7	titin	28,33	Calcium	titin	MESH:D002118	7273	Chemical	Gene	transients|nsubj|START_ENTITY transients|xcomp|regulate regulate|dobj|organization organization|compound|END_ENTITY	Calcium transients regulate titin organization during myofibrillogenesis .
20507834	0	Calcium	0,7	titin	83,88	Calcium	titin	MESH:D002118	22138(Tax:10090)	Chemical	Gene	sensitivity|amod|START_ENTITY increased|nsubjpass|sensitivity increased|nmod|mice mice|compound|END_ENTITY	Calcium sensitivity and the Frank-Starling mechanism of the heart are increased in titin N2B region-deficient mice .
23246787	0	Calcium	0,7	titin	57,62	Calcium	titin	MESH:D002118	22138(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Calcium sensitivity and myofilament lattice structure in titin N2B KO mice .
8099784	0	Calcium	0,7	transglutaminase	103,119	Calcium	transglutaminase	MESH:D002118	7051	Chemical	Gene	pretreatment|compound|START_ENTITY induces|nsubj|pretreatment induces|xcomp|binding binding|nmod|activation activation|nmod|END_ENTITY	Calcium pretreatment induces the decrease in epidermal_growth_factor binding through the activation of transglutaminase in isolated liver membrane .
3792134	0	Calcium	0,7	troponin_C	35,45	Calcium	troponin C	MESH:D002118	100540402	Chemical	Gene	START_ENTITY|xcomp|binding binding|nmod|END_ENTITY	Calcium binding to skeletal muscle troponin_C and the regulation of muscle contraction .
3941095	0	Calcium	0,7	troponin_C	45,55	Calcium	troponin C	MESH:D002118	3371	Chemical	Gene	sites|amod|START_ENTITY sites|nmod|END_ENTITY	Calcium binding to the low affinity sites in troponin_C induces conformational changes in the high affinity domain .
21887707	0	Calcium	0,7	vitamin_D_receptor	83,101	Calcium	vitamin D receptor	MESH:D002118	7421	Chemical	Gene	intake|amod|START_ENTITY intake|dep|modification modification|nmod|genotype genotype|compound|END_ENTITY	Calcium intake and prostate_cancer among African Americans : effect modification by vitamin_D_receptor calcium absorption genotype .
8530616	0	Calcium	0,7	vitamin_D_receptor	66,84	Calcium	vitamin D receptor	MESH:D002118	7421	Chemical	Gene	absorption|amod|START_ENTITY intakes|nsubj|absorption intakes|nmod|genotype genotype|compound|END_ENTITY	Calcium absorption on high and low calcium intakes in relation to vitamin_D_receptor genotype .
25433580	0	Calcium_Fructoborate	11,31	C-Reactive_Protein	45,63	Calcium Fructoborate	C-Reactive Protein	MESH:C507177	1401	Chemical	Gene	START_ENTITY|nmod|Levels Levels|nmod|END_ENTITY	Effects of Calcium_Fructoborate on Levels of C-Reactive_Protein , Total Cholesterol , Low-Density Lipoprotein , Triglycerides , IL-1b , IL-6 , and MCP-1 : a Double-blind , Placebo-controlled Clinical Study .
24754833	0	Calcium_Phosphate	0,17	Interleukin-8	35,48	Calcium Phosphate	Interleukin-8	MESH:C020243	3576	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Calcium_Phosphate Particles Induce Interleukin-8 Expression in a Human Gingival Epithelial Cell Line via the Nuclear Factor-kB Signaling Pathway .
26877731	0	Calcium_Sulfate	45,60	Bone_Morphogenetic_Protein_2	96,124	Calcium Sulfate	Bone Morphogenetic Protein 2	MESH:D002133	650	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Cytotoxic Effects and Osteogenic Activity of Calcium_Sulfate with and without Recombinant Human Bone_Morphogenetic_Protein_2 and Nano-Hydroxyapatite Adjacent to MG-63 Cell Line .
23335852	0	Calcium_dobesilate	0,18	endothelin-1	27,39	Calcium dobesilate	endothelin-1	MESH:D002123	1906	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|levels levels|amod|END_ENTITY	Calcium_dobesilate reduces endothelin-1 and high-sensitivity C-reactive protein serum levels in patients with diabetic_retinopathy .
1822027	0	Calcium_oxalate	0,15	mucin	50,55	Calcium oxalate	mucin	MESH:D002129	100508689	Chemical	Gene	START_ENTITY|nmod|presence presence|nmod|END_ENTITY	Calcium_oxalate crystal growth in the presence of mucin .
10950876	0	Calcyclin	0,9	CacyBP	36,42	Calcyclin	CacyBP	null	289144(Tax:10116)	Chemical	Gene	_|compound|START_ENTITY _|appos|END_ENTITY	Calcyclin _ -LRB- S100A6 -RRB- _ binding_protein -LRB- CacyBP -RRB- is highly expressed in brain neurons .
12713420	0	Callysponginol_sulfate_A	0,24	MT1-MMP	29,36	Callysponginol sulfate A	MT1-MMP	MESH:C477589	4323	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Callysponginol_sulfate_A , an MT1-MMP inhibitor isolated from the marine sponge Callyspongia truncata .
2960681	0	Calmidazolium	0,13	calmodulin	17,27	Calmidazolium	calmodulin	MESH:C031938	808	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Calmidazolium , a calmodulin antagonist , stimulates calcium-troponin_C and calcium-calmodulin-dependent activation of striated muscle_myofilaments .
21544553	0	Calpain	0,7	cyclin-dependent_kinase_inhibitor_1B	18,54	Calpain	cyclin-dependent kinase inhibitor 1B	null	12576(Tax:10090)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Calpain modulates cyclin-dependent_kinase_inhibitor_1B -LRB- p27 -LRB- Kip1 -RRB- -RRB- in cells of the osteoblast lineage .
3030436	0	Calpain	0,7	filamin	32,39	Calpain	filamin	null	2318	Chemical	Gene	abolishes|nsubj|START_ENTITY abolishes|dobj|effect effect|nmod|END_ENTITY	Calpain abolishes the effect of filamin on the actomyosin system in platelets .
17162536	0	Calpain	0,7	iNOS	30,34	Calpain	iNOS	null	24599(Tax:10116)	Chemical	Gene	attenuates|compound|START_ENTITY END_ENTITY|nsubj|attenuates	Calpain inhibition attenuates iNOS production and midzonal_hepatic_necrosis in a repeat dose model of endotoxemia in rats .
21982763	0	Calpastatin	0,11	protein_never_in_mitosis_gene_A_interacting-1	28,73	Calpastatin	protein never in mitosis gene A interacting-1	null	23988(Tax:10090)	Chemical	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Calpastatin is regulated by protein_never_in_mitosis_gene_A_interacting-1 -LRB- PIN1 -RRB- in endothelial cells .
22891683	0	Calretinin	0,10	huntingtin	26,36	Calretinin	huntingtin	null	3064	Chemical	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Calretinin interacts with huntingtin and reduces mutant huntingtin-caused cytotoxicity .
11278424	0	Calsenilin	0,10	caspase-3	30,39	Calsenilin	caspase-3	null	836	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Calsenilin is a substrate for caspase-3 that preferentially interacts with the familial_Alzheimer 's _ disease-associated C-terminal fragment of presenilin_2 .
21852538	0	Calsenilin	0,10	presenilin_1	21,33	Calsenilin	presenilin 1	null	5663	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Calsenilin regulates presenilin_1 / y-secretase-mediated N-cadherin - cleavage and b-catenin signaling .
26265982	0	Calycosin	23,32	Leukotriene_B4_12-Hydroxydehydrogenase	189,227	Calycosin	Leukotriene B4 12-Hydroxydehydrogenase	MESH:C121707	22949	Chemical	Gene	START_ENTITY|dep|Role Role|nmod|END_ENTITY	Plant Natural Products Calycosin and Gallic_Acid Synergistically Attenuate Neutrophil Infiltration and Subsequent Injury in Isoproterenol-Induced Myocardial_Infarction : A Possible Role for Leukotriene_B4_12-Hydroxydehydrogenase ?
11131152	0	Calyculin_A	0,11	CD8alpha	35,43	Calyculin A	CD8alpha	MESH:C059041	925	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Calyculin_A inhibits expression of CD8alpha but not CD4 in human peripheral blood T cells .
17666953	12	Calyculin_A	1828,1839	MLCP	1845,1849	Calyculin A	MLCK	MESH:C059041	288057(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Calyculin_A , the MLCP inhibitor , further enhanced Ang-II-induced increase of calcium sensitivity , but ML-9 , the MLCK inhibitor , had no effect .
12123810	3	Calyculin_A	580,591	PP1	601,604	Calyculin A	PP1	MESH:C059041	5464	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Calyculin_A , another PP1 and PP2A inhibitor , behaved similarly although these compounds are not structurally related .
17482757	0	Calyculin_A	0,11	TNF-alpha	41,50	Calyculin A	TNF-alpha	MESH:C059041	21926(Tax:10090)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|nmod|mRNA mRNA|amod|END_ENTITY	Calyculin_A stimulates the expression of TNF-alpha mRNA via phosphorylation of Akt in mouse osteoblastic MC3T3-E1 cells .
26973671	0	Camalexin	95,104	Cytochrome_P450_83A1_Monooxygenase	50,84	Camalexin	Cytochrome P450 83A1 Monooxygenase	MESH:C102405	827011(Tax:3702)	Chemical	Gene	Accumulation|compound|START_ENTITY Accumulation|compound|END_ENTITY	Mutation of the Glucosinolate Biosynthesis Enzyme Cytochrome_P450_83A1_Monooxygenase Increases Camalexin Accumulation and Powdery Mildew Resistance .
26010541	0	Cambinol	0,8	Neutral_Sphingomyelinase_2	31,57	Cambinol	Neutral Sphingomyelinase 2	MESH:C510718	55512	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|nmod|END_ENTITY	Cambinol , a Novel Inhibitor of Neutral_Sphingomyelinase_2 Shows Neuroprotective Properties .
26010541	0	Cambinol	0,8	neutral_sphingomyelinase_2	31,57	Cambinol	Neutral Sphingomyelinase 2	MESH:C510718	55512	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Cambinol , a novel inhibitor of neutral_sphingomyelinase_2 shows neuroprotective properties .
16616424	0	Campest-5-en-3-one	0,18	PPARalpha	69,78	Campest-5-en-3-one	PPARalpha	MESH:C413894	25747(Tax:10116)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Campest-5-en-3-one , an oxidized derivative of campesterol , activates PPARalpha , promotes energy consumption and reduces visceral fat deposition in rats .
26784701	0	Camphene	0,8	SREBP-1	84,91	Camphene	SREBP-1	MESH:C019286	78968(Tax:10116)	Chemical	Gene	Exerts|nsubj|START_ENTITY Exerts|nmod|END_ENTITY	Camphene , a Plant Derived Monoterpene , Exerts Its Hypolipidemic Action by Affecting SREBP-1 and MTP Expression .
23828908	0	Camphor	0,7	transient_receptor_potential_melastatin_8	33,74	Camphor	transient receptor potential melastatin 8	MESH:D002164	79054	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Camphor activates and sensitizes transient_receptor_potential_melastatin_8 -LRB- TRPM8 -RRB- to cooling and icilin .
21174601	0	Camptothecin	0,12	FOXO1	79,84	Camptothecin	FOXO1	MESH:D002166	2308	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|apoptosis apoptosis|nmod|cells cells|nmod|activation activation|nmod|END_ENTITY	Camptothecin induces apoptosis of human retinoblastoma cells via activation of FOXO1 .
26959889	0	Camptothecin	0,12	WRN	21,24	Camptothecin	WRN	MESH:D002166	7486	Chemical	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Camptothecin targets WRN protein : mechanism and relevance in clinical breast_cancer .
22071521	0	Camptothecin	0,12	heterogeneous_nuclear_ribonucleoprotein_A1	43,85	Camptothecin	heterogeneous nuclear ribonucleoprotein A1	MESH:D002166	3178	Chemical	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Camptothecin -LRB- CPT -RRB- directly binds to human heterogeneous_nuclear_ribonucleoprotein_A1 -LRB- hnRNP_A1 -RRB- and inhibits the hnRNP_A1 / topoisomerase I interaction .
2819731	0	Camptothecin	0,12	hsp_70	22,28	Camptothecin	hsp 70	MESH:D002166	44920(Tax:7227)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|transcription transcription|amod|END_ENTITY	Camptothecin inhibits hsp_70 heat-shock transcription and induces DNA strand breaks in hsp_70 genes in Drosophila .
25941985	0	Camptothecin	0,12	matrix_metalloproteinase-9	38,64	Camptothecin	matrix metalloproteinase-9	MESH:D002166	4318	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|nmod|END_ENTITY	Camptothecin suppresses expression of matrix_metalloproteinase-9 and vascular_endothelial_growth_factor in DU145 cells through PI3K/Akt-mediated inhibition of NF-kB activity and Nrf2-dependent induction of HO-1 expression .
7538195	0	Camptothecin	0,12	topoisomerase_I	74,89	Camptothecin	topoisomerase I	MESH:D002166	7150	Chemical	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	Camptothecin induction of a time - and concentration-dependent decrease of topoisomerase_I and its implication in camptothecin activity .
2850477	0	Camptothecin	0,12	type_I_DNA_topoisomerase	38,62	Camptothecin	type I DNA topoisomerase	MESH:D002166	7150	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Camptothecin , a specific inhibitor of type_I_DNA_topoisomerase , induces DNA breakage at replication forks .
26679969	0	Canagliflozin	82,95	DPP-4	103,108	Canagliflozin	DPP-4	MESH:C552334	1803	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|compound|END_ENTITY	Demographic and Clinical Profiles of Type 2 Diabetes_Mellitus Patients Initiating Canagliflozin Versus DPP-4 Inhibitors in a Large U.S. Managed Care Population .
24259694	0	Canagliflozin	0,13	SGLT2	23,28	Canagliflozin	SGLT2	MESH:C552334	6524	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Canagliflozin , a novel SGLT2 inhibitor for treatment of type 2 diabetes .
24741548	0	Canagliflozin	0,13	SGLT2	23,28	Canagliflozin	SGLT2	MESH:C552334	6524	Chemical	Gene	START_ENTITY|dep|Inhibitor Inhibitor|compound|END_ENTITY	Canagliflozin : A Novel SGLT2 Inhibitor for Type 2 Diabetes_Mellitus .
25796788	0	Canagliflozin	1,14	SGLT2	34,39	Canagliflozin	SGLT2	MESH:C552334	6524	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nummod|END_ENTITY	-LSB- Canagliflozin -LRB- Invokana -RRB- : kidney SGLT2 cotransporter inhibitor for treating type 2 diabetes -RSB- .
26629269	0	Canagliflozin	11,24	SGLT2	83,88	Canagliflozin	SGLT2	MESH:C552334	6524	Chemical	Gene	Invokamet|appos|START_ENTITY Invokamet|dep|Combination Combination|nmod|Approved Approved|compound|END_ENTITY	Invokamet -LRB- Canagliflozin plus Metformin_HCl -RRB- : First Fixed-Dose Combination with an SGLT2 Inhibitor Approved for the Treatment of Patients with Type 2 Diabetes .
16644319	0	Candesartan	113,124	angiotensin-converting_enzyme	35,64	Candesartan	angiotensin-converting enzyme	MESH:C081643	1636	Chemical	Gene	candesartan|nmod|START_ENTITY benefits|nmod|candesartan inhibitor|nmod|benefits inhibitor|amod|END_ENTITY	Relationship of dose of background angiotensin-converting_enzyme inhibitor to the benefits of candesartan in the Candesartan in Heart failure : Assessment of Reduction in Mortality and morbidity -LRB- CHARM -RRB- - Added trial .
19015603	0	Candesartan	0,11	angiotensin-converting_enzyme	56,85	Candesartan	angiotensin-converting enzyme	MESH:C081643	11421(Tax:10090)	Chemical	Gene	cardiac_dysfunction|compound|START_ENTITY observed|nsubj|cardiac_dysfunction observed|nmod|mice mice|amod|END_ENTITY	Candesartan ameliorates cardiac_dysfunction observed in angiotensin-converting_enzyme 2-deficient mice .
12944495	0	Candesartan	0,11	angiotensin_II	16,30	Candesartan	angiotensin II	MESH:C081643	24179(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Candesartan , an angiotensin_II receptor antagonist , suppresses pancreatic_inflammation and fibrosis in rats .
15164328	0	Candesartan	0,11	angiotensin_II	16,30	Candesartan	angiotensin II	MESH:C081643	183	Chemical	Gene	START_ENTITY|appos|blocker blocker|amod|END_ENTITY	Candesartan , an angiotensin_II receptor blocker , improves left_ventricular_hypertrophy and insulin resistance .
22892395	0	Candesartan	0,11	angiotensin_II	16,30	Candesartan	angiotensin II	MESH:C081643	11606(Tax:10090)	Chemical	Gene	START_ENTITY|appos|AT AT|amod|END_ENTITY	Candesartan , an angiotensin_II AT - receptor blocker and PPAR-y agonist , reduces lesion volume and improves motor and memory function after traumatic_brain_injury in mice .
16766543	0	Candesartan	0,11	angiotensin_II_type-1_receptor	16,46	Candesartan	angiotensin II type-1 receptor	MESH:C081643	185	Chemical	Gene	START_ENTITY|appos|blocker blocker|amod|END_ENTITY	Candesartan , an angiotensin_II_type-1_receptor blocker , reduces cardiovascular_events in patients on chronic haemodialysis -- a randomized study .
22543084	0	Candesartan	0,11	angiotensin_II_type_1_receptor	16,46	Candesartan	angiotensin II type 1 receptor	MESH:C081643	185	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Candesartan , an angiotensin_II_type_1_receptor antagonist , inhibits pathological retinal_neovascularization by downregulating VEGF receptor-2 expression .
24343720	0	Candesartan	0,11	angiotensin_II_type_1_receptor	124,154	Candesartan	angiotensin II type 1 receptor	MESH:C081643	185	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|likely likely|nmod|pathway pathway|amod|END_ENTITY	Candesartan inhibits LPS-induced expression increase of toll-like_receptor_4 and downstream inflammatory factors likely via angiotensin_II_type_1_receptor independent pathway in human renal tubular epithelial cells .
9331007	0	Candesartan_cilexetil	0,21	angiotensin_II	40,54	Candesartan cilexetil	angiotensin II	MESH:C077793	183	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Candesartan_cilexetil , a new generation angiotensin_II antagonist , provides dose dependent antihypertensive effect .
1315825	0	Candoxatril	0,11	atrial_natriuretic_factor	77,102	Candoxatril	atrial natriuretic factor	MESH:C062766	4878	Chemical	Gene	raises|nsubj|START_ENTITY raises|dobj|END_ENTITY	Candoxatril , an orally active neutral endopeptidase inhibitor , raises plasma atrial_natriuretic_factor and is natriuretic in essential hypertension .
12576724	0	Canine	0,6	Bcl-xL	7,13	Canine	Bcl-xL	null	598	Chemical	Gene	START_ENTITY|dobj|gene gene|amod|END_ENTITY	Canine Bcl-xL gene and its expression in tumor cell lines .
23510416	0	Canine	0,6	DLA-79	7,13	Canine	DLA-79	null	483594(Tax:9615)	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Canine DLA-79 gene : an improved typing method , identification of new alleles and its role in graft rejection and graft-versus-host disease .
26678019	0	Canine	14,20	Lipase	39,45	Canine	Lipase	null	404010(Tax:9615)	Chemical	Gene	Activity|compound|START_ENTITY Activity|compound|END_ENTITY	Evaluation of Canine Pancreas-Specific Lipase Activity , Lipase Activity , and Trypsin-Like Immunoreactivity in an Experimental Model of Acute_Kidney_Injury in Dogs .
25297547	0	Canine	0,6	PTGES	44,49	Canine	PTGES	null	480698(Tax:9615)	Chemical	Gene	Synthase|compound|START_ENTITY Synthase|appos|END_ENTITY	Canine Placental Prostaglandin_E2 Synthase -LRB- PTGES -RRB- : Expression , Localization , and Biological Functions in Providing Substrates for Prepartum PGF2alpha Synthesis .
19946423	0	Canine	35,41	eIF2alpha	57,66	Canine	eIF2alpha	null	83939	Chemical	Gene	Kinase|compound|START_ENTITY Kinase|compound|END_ENTITY	Functional Characterization of the Canine Heme-Regulated eIF2alpha Kinase : Regulation of Protein Synthesis .
8519911	0	Canine	0,6	erythropoietin	14,28	Canine	erythropoietin	null	404002(Tax:9615)	Chemical	Gene	START_ENTITY|dobj|levels levels|compound|END_ENTITY	Canine plasma erythropoietin levels in 124 cases of anemia .
15158372	0	Cannabidiol	0,11	Fos	22,25	Cannabidiol	Fos	MESH:D002185	314322(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Cannabidiol increases Fos expression in the nucleus accumbens but not in the dorsal striatum .
17672854	0	Cannabidiol	0,11	TRPV1	148,153	Cannabidiol	TRPV1	MESH:D002185	83810(Tax:10116)	Chemical	Gene	reduced|nsubj|START_ENTITY reduced|ccomp|caused caused|nmod|mechanisms mechanisms|nmod|activation activation|nmod|END_ENTITY	Cannabidiol reduced the striatal atrophy caused 3-nitropropionic_acid in vivo by mechanisms independent of the activation of cannabinoid , vanilloid TRPV1 and adenosine_A2A_receptors .
23893294	0	Cannabidiol	0,11	caspase_3	23,32	Cannabidiol	caspase 3	MESH:D002185	25402(Tax:10116)	Chemical	Gene	normalizes|nsubj|START_ENTITY normalizes|dobj|END_ENTITY	Cannabidiol normalizes caspase_3 , synaptophysin , and mitochondrial fission protein DNM1L expression levels in rats with brain iron overload : implications for neuroprotection .
26187180	0	Cannabidiol	0,11	cytochrome_P450_1A1	40,59	Cannabidiol	cytochrome P450 1A1	MESH:D002185	1543	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Cannabidiol induces expression of human cytochrome_P450_1A1 that is possibly mediated through aryl_hydrocarbon_receptor signaling in HepG2 cells .
26187180	0	Cannabidiol	0,11	cytochrome_P450_1A1	40,59	Cannabidiol	cytochrome P450 1A1	MESH:D002185	1543	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Cannabidiol induces expression of human cytochrome_P450_1A1 that is possibly mediated through aryl_hydrocarbon_receptor signaling in HepG2 cells .
23318708	0	Cannabidiol	0,11	cytochrome_P450_2C19	63,83	Cannabidiol	cytochrome P450 2C19	MESH:D002185	1557	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|activity activity|nmod|END_ENTITY	Cannabidiol is a potent inhibitor of the catalytic activity of cytochrome_P450_2C19 .
10336560	0	Cannabinoid	0,11	CB2	89,92	Cannabinoid	CB2	CHEBI:67194	1269	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|dep|evidence evidence|nmod|participation participation|compound|END_ENTITY	Cannabinoid inhibition of the processing of intact lysozyme by macrophages : evidence for CB2 receptor participation .
18614816	0	Cannabinoid	0,11	CB2	13,16	Cannabinoid	CB2	CHEBI:67194	1269	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dep|END_ENTITY	Cannabinoid -LRB- CB2 -RRB- receptor deficiency reduces the susceptibility of macrophages to oxidized LDL/oxysterol-induced apoptosis .
20846652	0	Cannabinoid	0,11	CB2	29,32	Cannabinoid	CB2	CHEBI:67194	12802(Tax:10090)	Chemical	Gene	type|amod|START_ENTITY type|dep|deficiency deficiency|compound|END_ENTITY	Cannabinoid receptor type 2 -LRB- CB2 -RRB- deficiency alters atherosclerotic_lesion formation in hyperlipidemic Ldlr-null mice .
24900561	0	Cannabinoid	59,70	CB2	71,74	Cannabinoid	CB2	CHEBI:67194	1269	Chemical	Gene	Receptors|compound|START_ENTITY Receptors|compound|END_ENTITY	Magnolia Extract , Magnolol , and Metabolites : Activation of Cannabinoid CB2 Receptors and Blockade of the Related GPR55 .
18579347	0	Cannabinoid	0,11	CNR1	24,28	Cannabinoid	CNR1	CHEBI:67194	1268	Chemical	Gene	receptor|amod|START_ENTITY receptor|dep|gene gene|compound|END_ENTITY	Cannabinoid receptor 1 -LRB- CNR1 -RRB- gene : impact on antidepressant treatment response and emotion processing in major depression .
9106242	0	Cannabinoid	0,11	CNR1	27,31	Cannabinoid	CNR1	CHEBI:67194	1268	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cannabinoid receptor gene -LRB- CNR1 -RRB- : association with i.v. drug use .
24900561	0	Cannabinoid	59,70	GPR55	113,118	Cannabinoid	GPR55	CHEBI:67194	9290	Chemical	Gene	Receptors|compound|START_ENTITY Activation|nmod|Receptors Activation|nmod|END_ENTITY	Magnolia Extract , Magnolol , and Metabolites : Activation of Cannabinoid CB2 Receptors and Blockade of the Related GPR55 .
25340978	0	Cantharidin	0,11	Cdc25c	55,61	Cantharidin	Cdc25c	MESH:D002193	995	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|inhibition inhibition|nmod|END_ENTITY	Cantharidin induces G2/M phase arrest by inhibition of Cdc25c and Cyclin_A and triggers apoptosis through reactive oxygen species and the mitochondria - dependent pathways of A375.S2 human melanoma cells .
20331621	0	Cantharidin	0,11	PP2A	36,40	Cantharidin	PP2A	MESH:D002193	5524	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Cantharidin , a potent and selective PP2A inhibitor , induces an oxidative stress-independent growth inhibition of pancreatic_cancer cells through G2/M cell-cycle arrest and apoptosis .
25242927	0	Canthaxanthin	0,13	HS-1	53,57	Canthaxanthin	HS-1	MESH:D016644	1917	Chemical	Gene	biosynthesis|compound|START_ENTITY biosynthesis|nmod|END_ENTITY	Canthaxanthin biosynthesis by Dietzia natronolimnaea HS-1 : effects of inoculation and aeration rate .
25964250	0	Capecitabine	52,64	S0809	5,10	Capecitabine	S0809	MESH:C110904	1077224(Tax:198215)	Chemical	Gene	Trial|nmod|START_ENTITY END_ENTITY|dep|Trial	SWOG S0809 : A Phase II Intergroup Trial of Adjuvant Capecitabine and Gemcitabine Followed by Radiotherapy and Concurrent Capecitabine in Extrahepatic_Cholangiocarcinoma and Gallbladder_Carcinoma .
25964250	0	Capecitabine	52,64	S0809	5,10	Capecitabine	S0809	MESH:C110904	1077224(Tax:198215)	Chemical	Gene	Trial|nmod|START_ENTITY END_ENTITY|dep|Trial	SWOG S0809 : A Phase II Intergroup Trial of Adjuvant Capecitabine and Gemcitabine Followed by Radiotherapy and Concurrent Capecitabine in Extrahepatic_Cholangiocarcinoma and Gallbladder_Carcinoma .
24333736	0	Capillarisin	0,12	STAT3	49,54	Capillarisin	STAT3	MESH:C011185	6774	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|compound|END_ENTITY	Capillarisin inhibits constitutive and inducible STAT3 activation through induction of SHP-1 and SHP-2 tyrosine phosphatases .
23131135	0	Capillarisin	0,12	iNOS	22,26	Capillarisin	iNOS	MESH:C011185	18126(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Capillarisin inhibits iNOS , COX-2 expression , and proinflammatory cytokines in LPS-induced RAW 264.7 macrophages via the suppression of ERK , JNK , and NF-kB activation .
15778318	0	Caprine	0,7	CSN3	22,26	Caprine	CSN3	CHEBI:44556	100861231	Chemical	Gene	polymorphism|compound|START_ENTITY polymorphism|appos|END_ENTITY	Caprine kappa-casein -LRB- CSN3 -RRB- polymorphism : new developments in molecular knowledge .
25167771	0	Capsaicin	0,9	BAFF	37,41	Capsaicin	BAFF	MESH:D002211	10673	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Capsaicin induces high expression of BAFF and aberrantly glycosylated IgA1 of tonsillar mononuclear cells in IgA_nephropathy patients .
2427561	0	Capsaicin	0,9	CGRP	66,70	Capsaicin	CGRP	MESH:D002211	24241(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|depletion depletion|nmod|peptide peptide|appos|END_ENTITY	Capsaicin induces a depletion of calcitonin gene-related peptide -LRB- CGRP -RRB- - immunoreactive nerves in the cardiovascular system of the guinea_pig and rat .
8387220	0	Capsaicin	0,9	CGRP	72,76	Capsaicin	CGRP	MESH:D002211	24241(Tax:10116)	Chemical	Gene	induced|compound|START_ENTITY afferent|nsubj|induced afferent|nmod|END_ENTITY	Capsaicin induced afferent denervation and receptor-linked responses to CGRP in the rat .
22648626	0	Capsaicin	0,9	CYP3A4	18,24	Capsaicin	CYP3A4	MESH:D002211	1576	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nummod|END_ENTITY	Capsaicin induces CYP3A4 expression via pregnane_X_receptor and CCAAT/enhancer-binding _ protein_b activation .
15076747	0	Capsaicin	0,9	GFAP	20,24	Capsaicin	GFAP	MESH:D002211	24387(Tax:10116)	Chemical	Gene	increases|compound|START_ENTITY END_ENTITY|nsubj|increases	Capsaicin increases GFAP and glutamine_synthetase immunoreactivity in rat arcuate nucleus and median eminence .
17306835	0	Capsaicin	0,9	IL-6	36,40	Capsaicin	IL-6	MESH:D002211	3569	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|nmod|END_ENTITY	Capsaicin induces the production of IL-6 in human upper respiratory epithelial cells .
23194965	0	Capsaicin	35,44	Interleukin-1a	48,62	Capsaicin	Interleukin-1a	MESH:D002211	3552	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Dose-dependent reversal effects of Capsaicin on Interleukin-1a production is associated with the metabolism of arachidonic_acid -LRB- leukotriene_B -LRB- 4 -RRB- and prostaglandin_E -LRB- 2 -RRB- -RRB- as well as nitric_oxide production in human leukocytes .
15781048	0	Capsaicin	0,9	TRPV1	88,93	Capsaicin	TRPV1	MESH:D002211	83810(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY secretion|appos|END_ENTITY	Capsaicin - and anandamide-induced gastric_acid secretion via vanilloid receptor type 1 -LRB- TRPV1 -RRB- in rat brain .
17274957	0	Capsaicin	0,9	TRPV1	82,87	Capsaicin	TRPV1	MESH:D002211	7442	Chemical	Gene	causes|nsubj|START_ENTITY causes|dobj|inhibition inhibition|nmod|activities activities|nummod|END_ENTITY	Capsaicin causes protein synthesis inhibition and microtubule disassembly through TRPV1 activities both on the plasma membrane and intracellular membranes .
18209521	0	Capsaicin	0,9	TRPV1	11,16	Capsaicin	TRPV1	MESH:D002211	7442	Chemical	Gene	therapy|amod|START_ENTITY therapy|appos|Agonist Agonist|compound|END_ENTITY	Capsaicin -LRB- TRPV1 Agonist -RRB- therapy for pain relief : farewell or revival ?
21156986	0	Capsaicin	0,9	TRPV1	67,72	Capsaicin	TRPV1	MESH:D002211	83810(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	Capsaicin indirectly suppresses voltage-gated Na + currents through TRPV1 in rat dorsal root ganglion neurons .
22548186	0	Capsaicin	0,9	TRPV1	13,18	Capsaicin	TRPV1	MESH:D002211	193034(Tax:10090)	Chemical	Gene	START_ENTITY|appos|Ligand Ligand|compound|END_ENTITY	Capsaicin , a TRPV1 Ligand , Suppresses Bone Resorption by Inhibiting the Prostaglandin_E Production of Osteoblasts , and Attenuates the Inflammatory Bone Loss Induced by Lipopolysaccharide .
22792028	0	Capsaicin	0,9	TRPV1	69,74	Capsaicin	TRPV1	MESH:D002211	83810(Tax:10116)	Chemical	Gene	Blocks|nsubj|START_ENTITY Blocks|dobj|Currents Currents|nmod|END_ENTITY	Capsaicin Blocks the Hyperpolarization-Activated Inward Currents via TRPV1 in the Rat Dorsal Root Ganglion Neurons .
24139494	0	Capsaicin	0,9	TRPV1	123,128	Capsaicin	TRPV1	MESH:D002211	7442	Chemical	Gene	treatment|compound|START_ENTITY reduces|nsubj|treatment reduces|dobj|overexpression overexpression|appos|END_ENTITY	Capsaicin treatment reduces nasal hyperreactivity and transient_receptor_potential_cation_channel_subfamily_V , _ receptor_1 -LRB- TRPV1 -RRB- overexpression in patients with idiopathic rhinitis .
25422952	0	Capsaicin	0,9	TRPV1	84,89	Capsaicin	TRPV1	MESH:D002211	7442	Chemical	Gene	decrease|amod|START_ENTITY fatty_acid|nsubj|decrease fatty_acid|xcomp|uptake uptake|nmod|activation activation|amod|END_ENTITY	Capsaicin , nonivamide and trans-pellitorine decrease free fatty_acid uptake without TRPV1 activation and increase acetyl-coenzyme A synthetase activity in Caco-2 cells .
26502196	0	Capsaicin	11,20	TRPV1	28,33	Capsaicin	TRPV1	MESH:D002211	7442	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|Channel Channel|compound|END_ENTITY	Binding of Capsaicin to the TRPV1 Ion Channel .
26648574	0	Capsaicin	0,9	TRPV1	77,82	Capsaicin	TRPV1	MESH:D002211	7442	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|efficacy efficacy|nmod|pirarubicin pirarubicin|acl|activating activating|dobj|END_ENTITY	Capsaicin enhances anti-proliferation efficacy of pirarubicin via activating TRPV1 and inhibiting PCNA nuclear translocation in 5637 cells .
26884754	0	Capsaicin	41,50	TRPV1	12,17	Capsaicin	TRPV1	MESH:D002211	7442	Chemical	Gene	Psychophysics|compound|START_ENTITY Function|nmod|Psychophysics Function|compound|END_ENTITY	Integrating TRPV1 Receptor Function with Capsaicin Psychophysics .
10869604	0	Capsaicin	0,9	VR1	104,107	Capsaicin	VR1	MESH:D002211	83810(Tax:10116)	Chemical	Gene	acid|compound|START_ENTITY currents|compound|acid currents|dep|relationship relationship|nmod|receptors receptors|amod|functional functional|dep|END_ENTITY	Capsaicin , acid and heat-evoked currents in rat trigeminal ganglion neurons : relationship to functional VR1 receptors .
12719227	0	Capsaicin	0,9	VR1	43,46	Capsaicin	VR1	MESH:D002211	7442	Chemical	Gene	activation|compound|START_ENTITY activation|nmod|receptor receptor|appos|END_ENTITY	Capsaicin activation of the pain receptor , VR1 : multiple open states from both partial and full binding .
9708861	0	Capsaicin	0,9	VR1	95,98	Capsaicin	VR1	MESH:D002211	83810(Tax:10116)	Chemical	Gene	sensitivity|compound|START_ENTITY associated|nsubjpass|sensitivity associated|nmod|expression expression|nmod|mRNA mRNA|appos|END_ENTITY	Capsaicin sensitivity is associated with the expression of the vanilloid _ -LRB- capsaicin -RRB- _ receptor -LRB- VR1 -RRB- mRNA in adult rat sensory ganglia .
19059400	0	Capsaicin	0,9	androgen_receptor	61,78	Capsaicin	androgen receptor	MESH:D002211	367	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Capsaicin , a component of red peppers , induces expression of androgen_receptor via PI3K and MAPK pathways in prostate LNCaP cells .
26081756	0	Capsaicin	0,9	androgen_receptor	53,70	Capsaicin	androgen receptor	MESH:D002211	367	Chemical	Gene	causes|nsubj|START_ENTITY causes|dobj|inactivation inactivation|nmod|END_ENTITY	Capsaicin causes inactivation and degradation of the androgen_receptor by inducing the restoration of miR-449a in prostate_cancer .
11000490	0	Capsaicin	0,9	brain-derived_neurotrophic_factor	21,54	Capsaicin	brain-derived neurotrophic factor	MESH:D002211	24225(Tax:10116)	Chemical	Gene	effects|compound|START_ENTITY effects|nmod|END_ENTITY	Capsaicin effects on brain-derived_neurotrophic_factor in rat dorsal root ganglia and spinal cord .
2589542	0	Capsaicin	0,9	cholecystokinin	63,78	Capsaicin	cholecystokinin	MESH:D002211	25298(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|advcl|circulating circulating|dobj|END_ENTITY	Capsaicin attenuates hindbrain neuron responses to circulating cholecystokinin .
3192902	0	Capsaicin	0,9	cholecystokinin	56,71	Capsaicin	cholecystokinin	MESH:D002211	25298(Tax:10116)	Chemical	Gene	pretreatment|compound|START_ENTITY attenuates|nsubj|pretreatment attenuates|xcomp|END_ENTITY	Capsaicin pretreatment attenuates multiple responses to cholecystokinin in rats .
24682934	0	Capsaicin	0,9	cytochrome_c	41,53	Capsaicin	cytochrome c	MESH:D002211	54205	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|release release|amod|END_ENTITY	Capsaicin inhibits cell proliferation by cytochrome_c release in gastric_cancer cells .
17979524	0	Capsaicin	0,9	heme_oxygenase-1	18,34	Capsaicin	heme oxygenase-1	MESH:D002211	3162	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Capsaicin induces heme_oxygenase-1 expression in HepG2 cells via activation of PI3K-Nrf2 signaling : NAD -LRB- P -RRB- H : quinone oxidoreductase as a potential target .
24642709	0	Capsaicin	0,9	heme_oxygenase-1	74,90	Capsaicin	heme oxygenase-1	MESH:D002211	3162	Chemical	Gene	ameliorates|nsubj|START_ENTITY ameliorates|nmod|induction induction|nmod|END_ENTITY	Capsaicin ameliorates cisplatin-induced renal_injury through induction of heme_oxygenase-1 .
21745629	0	Capsaicin	0,9	macrophage_inflammatory_protein_1	53,86	Capsaicin	macrophage inflammatory protein 1	MESH:D002211	79109	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|nmod|END_ENTITY	Capsaicin attenuates palmitate-induced expression of macrophage_inflammatory_protein_1 and interleukin_8 by increasing palmitate oxidation and reducing c-Jun activation in THP-1 -LRB- human acute_monocytic_leukemia cell -RRB- cells .
15383218	0	Capsaicin	0,9	peroxisome_proliferator-activated_receptor_gamma	83,131	Capsaicin	peroxisome proliferator-activated receptor gamma	MESH:D002211	5468	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Capsaicin , a spicy component of hot pepper , induces apoptosis by activation of the peroxisome_proliferator-activated_receptor_gamma in HT-29 human colon_cancer cells .
22648626	0	Capsaicin	0,9	pregnane_X_receptor	40,59	Capsaicin	pregnane X receptor	MESH:D002211	8856	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Capsaicin induces CYP3A4 expression via pregnane_X_receptor and CCAAT/enhancer-binding _ protein_b activation .
19116139	0	Capsaicin	0,9	prohibitin_2	19,31	Capsaicin	prohibitin 2	MESH:D002211	11331	Chemical	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Capsaicin binds to prohibitin_2 and displaces it from the mitochondria to the nucleus .
20510015	0	Capsaicin	0,9	protein_kinase	50,64	Capsaicin	protein kinase	MESH:D002211	1022	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|amod|END_ENTITY	Capsaicin , a component of red peppers , stimulates protein_kinase CKII activity .
2408483	0	Capsaicin	0,9	substance_P	61,72	Capsaicin	substance P	MESH:D002211	6863	Chemical	Gene	effects|compound|START_ENTITY effects|dep|release release|compound|END_ENTITY	Capsaicin effects on muscularis mucosa of opossum esophagus : substance_P release from afferent nerves ?
15304360	0	Capsaicin	0,9	tumor_necrosis_factor_alpha	37,64	Capsaicin	tumor necrosis factor alpha	MESH:D002211	21926(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|nmod|END_ENTITY	Capsaicin inhibits the production of tumor_necrosis_factor_alpha by LPS-stimulated murine macrophages , RAW 264.7 : a PPARgamma ligand-like action as a novel mechanism .
12242509	0	Capsaicin	0,9	vascular_endothelial_cell_growth_factor	20,59	Capsaicin	vascular endothelial cell growth factor	MESH:D002211	7422	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Capsaicin regulates vascular_endothelial_cell_growth_factor expression by modulation of hypoxia inducing factor-1alpha in human malignant_melanoma cells .
22922338	0	Capsazepine	0,11	TRPV1	15,20	Capsazepine	TRPV1	MESH:C071423	7442	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Capsazepine , a TRPV1 antagonist , sensitizes colorectal_cancer cells to apoptosis by TRAIL through ROS-JNK-CHOP-mediated upregulation of death receptors .
27090778	0	Capsazepine	64,75	TRPV1	46,51	Capsazepine	TRPV1	MESH:C071423	193034(Tax:10090)	Chemical	Gene	Improves|nsubj|START_ENTITY Improves|dep|END_ENTITY	The Transient Receptor Potential Vanilloid 1 -LRB- TRPV1 -RRB- Antagonist Capsazepine Improves the Impaired Lung Mechanics during Endotoxemia .
23863923	0	Captodiamine	0,12	BDNF	63,67	Captodiamine	BDNF	MESH:C495502	627	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Captodiamine , a putative antidepressant , enhances hypothalamic BDNF expression in vivo by synergistic 5-HT2c receptor antagonism and sigma-1 receptor agonism .
11723089	0	Captopril	209,218	ACE	111,114	Captopril	ACE	CHEBI:3380	1636	Chemical	Gene	Project|compound|START_ENTITY subanalysis|nmod|Project cardiovascular_morbidity|dep|subanalysis cardiovascular_morbidity|nmod|patients patients|nmod|therapy therapy|nmod|inhibitor inhibitor|compound|END_ENTITY	Reduced cardiovascular_morbidity and mortality in hypertensive diabetic patients on first-line therapy with an ACE inhibitor compared with a diuretic/beta-blocker-based treatment regimen : a subanalysis of the Captopril Prevention Project .
15076172	0	Captopril	101,110	ACE	39,42	Captopril	ACE	CHEBI:3380	1636	Chemical	Gene	Project|compound|START_ENTITY subanalysis|nmod|Project inhibition|dep|subanalysis inhibition|compound|END_ENTITY	Development of diabetes is retarded by ACE inhibition in hypertensive patients -- a subanalysis of the Captopril Prevention Project -LRB- CAPPP -RRB- .
1929658	0	Captopril	0,9	ACE	14,17	Captopril	ACE	CHEBI:3380	613133(Tax:9823)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Captopril , an ACE inhibitor , for optimizing reperfusion after acute myocardial_infarction .
1313653	0	Captopril	0,9	ANF	43,46	Captopril	ANF	CHEBI:3380	608289(Tax:9615)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Captopril enhances renal responsiveness to ANF in dogs with compensated high-output heart_failure .
7986464	2	Captopril	173,182	Insulin	183,190	Captopril	Insulin	CHEBI:3380	3630	Chemical	Gene	Group|compound|START_ENTITY Group|compound|END_ENTITY	Captopril Insulin Sensitivity Multicenter Study Group .
10030325	0	Captopril	149,158	angiotensin-converting-enzyme	10,39	Captopril	angiotensin-converting-enzyme	D002216	1636	Chemical	Gene	Project|compound|START_ENTITY Effect|dep|Project Effect|nmod|inhibition inhibition|amod|END_ENTITY	Effect of angiotensin-converting-enzyme inhibition compared with conventional therapy on cardiovascular_morbidity and mortality in hypertension : the Captopril Prevention Project -LRB- CAPPP -RRB- randomised trial .
2997673	0	Captopril	0,9	angiotensin-converting_enzyme	45,74	Captopril	angiotensin-converting enzyme	CHEBI:3380	1636	Chemical	Gene	START_ENTITY|nmod|discriminators discriminators|nmod|activity activity|amod|END_ENTITY	Captopril and teprotide as discriminators of angiotensin-converting_enzyme activity in brain tissue .
1633064	0	Captopril	0,9	angiotensin_II	108,122	Captopril	angiotensin II	CHEBI:3380	183	Chemical	Gene	augments|nsubj|START_ENTITY augments|nmod|suppression suppression|acl|circulating circulating|dobj|END_ENTITY	Captopril augments both basal and frusemide-induced natriuresis in normal man by suppression of circulating angiotensin_II .
22994939	0	Captopril	0,9	angiotensin_II	54,68	Captopril	angiotensin II	CHEBI:3380	24179(Tax:10116)	Chemical	Gene	avoids|nsubj|START_ENTITY avoids|dobj|hypertension hypertension|appos|increase increase|nmod|END_ENTITY	Captopril avoids hypertension , the increase in plasma angiotensin_II but increases angiotensin 1-7 and angiotensin_II-induced perfusion pressure in isolated kidney in SHR .
6298670	0	Captopril	42,51	angiotensin_II	60,74	Captopril	angiotensin II	CHEBI:3380	24179(Tax:10116)	Chemical	Gene	blockade|nmod|START_ENTITY changes|nsubj|blockade changes|dobj|receptors receptors|compound|END_ENTITY	Angiotensin-converting enzyme blockade by Captopril changes angiotensin_II receptors and angiotensinogen concentrations in the brain of SHR-sp and WKY rats .
6362960	0	Captopril	0,9	angiotensin_II	58,72	Captopril	angiotensin II	CHEBI:3380	183	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Captopril enhances vascular and adrenal responsiveness to angiotensin_II in essential hypertension .
7039897	0	Captopril	61,70	angiotensin_II	90,104	Captopril	angiotensin II	CHEBI:3380	183	Chemical	Gene	SQ_14225|appos|START_ENTITY effects|nmod|SQ_14225 Comparison|nmod|effects Ileu8|nsubj|Comparison Ileu8|dobj|END_ENTITY	Comparison of the immediate hemodynamic effects of SQ_14225 -LRB- Captopril -RRB- and -LSB- Sar1 , Ileu8 -RSB- angiotensin_II in patients with dialysis resistant hypertension .
7041592	0	Captopril	0,9	angiotensin_II	105,119	Captopril	angiotensin II	CHEBI:3380	183	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|xcomp|norepinephrine norepinephrine|nmod|depletion depletion|nmod|END_ENTITY	Captopril attenuates pressor responses to norepinephrine and vasopressin through depletion of endogenous angiotensin_II .
6754215	0	Captopril	1,10	angiotensin_I_converting-enzyme	30,61	Captopril	angiotensin I converting-enzyme	CHEBI:3380	1636	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	-LSB- Captopril -LRB- oral inhibitor of angiotensin_I_converting-enzyme -RRB- in arterial hypertension -RSB- .
16631159	0	Captopril	0,9	angiotensin_converting_enzyme	131,160	Captopril	angiotensin converting enzyme	CHEBI:3380	1636	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|modification modification|nmod|apolipoprotein_B-100 apolipoprotein_B-100|acl|caused caused|nmod|assay assay|nmod|inhibitors inhibitors|amod|END_ENTITY	Captopril inhibits the oxidative modification of apolipoprotein_B-100 caused by myeloperoxydase in a comparative in vitro assay of angiotensin_converting_enzyme inhibitors .
1981218	0	Captopril	4,13	angiotensin_converting_enzyme	70,99	Captopril	angiotensin converting enzyme	CHEBI:3380	1636	Chemical	Gene	Project|compound|START_ENTITY Project|dep|trial trial|nmod|inhibition inhibition|amod|END_ENTITY	The Captopril Prevention Project : a prospective intervention trial of angiotensin_converting_enzyme inhibition in the treatment of hypertension .
2670794	0	Captopril	58,67	angiotensin_converting_enzyme	27,56	Captopril	angiotensin converting enzyme	D002216	24310(Tax:10116)	Chemical	Gene	Effects|appos|START_ENTITY Effects|nmod|inhibitor inhibitor|nmod|END_ENTITY	Effects of an inhibitor of angiotensin_converting_enzyme -LRB- Captopril -RRB- on pulmonary_and_renal_insufficiency due to intravascular_coagulation in the rat .
6148657	0	Captopril	0,9	angiotensin_converting_enzyme	52,81	Captopril	angiotensin converting enzyme	D002216	1636	Chemical	Gene	administration|amod|START_ENTITY impairs|nsubj|administration impairs|dobj|activity activity|compound|END_ENTITY	Captopril administration in pregnancy impairs fetal angiotensin_converting_enzyme activity and neonatal adaptation .
3003038	0	Captopril	113,122	bradykinin	65,75	Captopril	bradykinin	CHEBI:3380	3827	Chemical	Gene	comparison|nmod|START_ENTITY converstatin|nmod|comparison converstatin|compound|END_ENTITY	Potent inhibition of angiotensin-converting enzyme by -LSB- des-Pro3 -RSB- - bradykinin or `` converstatin '' in comparison with Captopril .
7896012	0	Captopril	0,9	bradykinin	63,73	Captopril	bradykinin	CHEBI:3380	3827	Chemical	Gene	increases|nsubj|START_ENTITY increases|xcomp|secondary secondary|nmod|END_ENTITY	Captopril increases skin microvascular blood flow secondary to bradykinin , nitric_oxide , and prostaglandins .
8389325	0	Captopril	0,9	bradykinin	73,83	Captopril	bradykinin	CHEBI:3380	3827	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Captopril inhibits endothelin-1 secretion from endothelial cells through bradykinin .
9384240	0	Captopril	0,9	c-src	24,29	Captopril	c-src	CHEBI:3380	6714	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Captopril inhibits pp60 -LRB- c-src -RRB- tyrosine phosphorylation in cultured human mesangial cells .
8389325	0	Captopril	0,9	endothelin-1	19,31	Captopril	endothelin-1	CHEBI:3380	1906	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|amod|END_ENTITY	Captopril inhibits endothelin-1 secretion from endothelial cells through bradykinin .
8481081	0	Captopril	0,9	interferon_gamma	28,44	Captopril	interferon gamma	CHEBI:3380	3458	Chemical	Gene	effect|amod|START_ENTITY effect|nmod|END_ENTITY	Captopril and the effect of interferon_gamma on monocytes .
25767848	0	Captopril	0,9	matrix_metalloproteinase-2	38,64	Captopril	matrix metalloproteinase-2	CHEBI:3380	4313	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|activity activity|amod|END_ENTITY	Captopril and lisinopril only inhibit matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- activity at millimolar concentrations .
7008259	0	Captopril	42,51	renin	20,25	Captopril	renin	CHEBI:3380	5972	Chemical	Gene	administration|appos|START_ENTITY Active|nmod|administration Active|dobj|END_ENTITY	Active and inactive renin after SQ_14225 -LRB- Captopril -RRB- administration .
7018804	0	Captopril	0,9	renin	103,108	Captopril	renin	CHEBI:3380	5972	Chemical	Gene	lowers|nsubj|START_ENTITY lowers|dobj|concentration concentration|dep|implications implications|nmod|methodology methodology|nmod|assays assays|compound|END_ENTITY	Captopril combined with thiazide lowers renin substrate concentration : implications for methodology in renin assays .
7018804	0	Captopril	0,9	renin	40,45	Captopril	renin	CHEBI:3380	5972	Chemical	Gene	lowers|nsubj|START_ENTITY lowers|dobj|concentration concentration|compound|END_ENTITY	Captopril combined with thiazide lowers renin substrate concentration : implications for methodology in renin assays .
8129537	0	Captopril	1,10	renin	71,76	Captopril	renin	CHEBI:3380	5972	Chemical	Gene	test|nsubj|START_ENTITY test|advcl|detecting detecting|dobj|renal_artery_stenosis renal_artery_stenosis|dep|changes changes|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Captopril test for detecting renal_artery_stenosis : changes in plasma renin concentration -RSB- .
8738111	0	Captopril	0,9	renin	20,25	Captopril	renin	CHEBI:3380	100724037	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|release release|compound|END_ENTITY	Captopril increases renin release stimulated by furosemide and hypotension in isolated perfused guinea_pig kidneys .
2435436	0	Captopril	0,9	substance_P	57,68	Captopril	substance P	CHEBI:3380	21333(Tax:10090)	Chemical	Gene	potentiate|nsubj|START_ENTITY potentiate|nmod|END_ENTITY	Captopril does not potentiate hypotension and algesia by substance_P .
11165202	0	Captopril	0,9	tumor_necrosis_factor-alpha	37,64	Captopril	tumor necrosis factor-alpha	CHEBI:3380	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|nmod|END_ENTITY	Captopril inhibits the production of tumor_necrosis_factor-alpha by human mononuclear cells in patients with congestive_heart_failure .
8719421	0	Carazolol	0,9	beta_3-adrenoceptor	31,50	Carazolol	beta 3-adrenoceptor	MESH:C014382	155	Chemical	Gene	START_ENTITY|dep|agonist agonist|amod|END_ENTITY	Carazolol : a potent , selective beta_3-adrenoceptor agonist .
10362652	0	Carbachol	0,9	ERK2	20,24	Carbachol	ERK2	MESH:D002217	5594	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Carbachol activates ERK2 in isolated gastric parietal cells via multiple signaling pathways .
20012300	0	Carbachol	0,9	TGF-alpha	18,27	Carbachol	TGF-alpha	MESH:D002217	24827(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Carbachol induces TGF-alpha expression and colonic epithelial cell proliferation in sensory-desensitised rats .
6177536	0	Carbachol	0,9	VIP	59,62	Carbachol	VIP	MESH:D002217	100735454	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|effect effect|nmod|END_ENTITY	Carbachol potentiates the cyclic_AMP-stimulating effect of VIP in cat submandibular gland .
9037533	0	Carbachol	0,9	c-fos	21,26	Carbachol	c-fos	MESH:D002217	2353	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Carbachol stimulates c-fos expression and proliferation in oligodendrocyte progenitors .
1620234	0	Carbachol	0,9	mucin	43,48	Carbachol	mucin	MESH:D002217	65202(Tax:10116)	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|secretion secretion|compound|END_ENTITY	Carbachol potentiates isoprenaline-induced mucin secretion by rat submandibular gland .
1417779	0	Carbachol	0,9	phospholipase_A2	25,41	Carbachol	phospholipase A2	MESH:D002217	151056	Chemical	Gene	stimulation|amod|START_ENTITY stimulation|nmod|END_ENTITY	Carbachol stimulation of phospholipase_A2 and insulin secretion in pancreatic islets .
23169765	0	Carbamate	0,9	AChE	24,28	Carbamate	AChE	CHEBI:28616	43	Chemical	Gene	protection|amod|START_ENTITY protection|nmod|END_ENTITY	Carbamate protection of AChE against inhibition by agricultural chemicals .
8374049	0	Carbamate	0,9	acetylcholinesterase	65,85	Carbamate	acetylcholinesterase	CHEBI:28616	11423(Tax:10090)	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|pyridinium_salts pyridinium_salts|nmod|inhibitors inhibitors|amod|END_ENTITY	Carbamate derivatives of 2-arylimidazo -LSB- 1,2-a -RSB- pyridinium_salts as acetylcholinesterase inhibitors and protective agents against organophosphorus compounds .
8374048	0	Carbamates	0,10	acetylcholinesterase	61,81	Carbamates	acetylcholinesterase	MESH:D002219	11423(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|methyl_heteroaromatic_salts methyl_heteroaromatic_salts|nmod|inhibitors inhibitors|amod|END_ENTITY	Carbamates of -LRB- hydroxyphenoxy -RRB- methyl_heteroaromatic_salts as acetylcholinesterase inhibitors and protective agents against organophosphorus compounds .
12458024	0	Carbamazepine	0,13	CYP2C19	84,91	Carbamazepine	CYP2C19	MESH:D002220	1557	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Carbamazepine and oxcarbazepine decrease phenytoin metabolism through inhibition of CYP2C19 .
10731628	0	Carbamazepine	0,13	Fos	49,52	Carbamazepine	Fos	MESH:D002220	314322(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Carbamazepine suppresses methamphetamine-induced Fos expression in a regionally specific manner in the rat brain .
11318771	0	Carbamazepine	0,13	P-glycoprotein	37,51	Carbamazepine	P-glycoprotein	MESH:D002220	5243	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Carbamazepine is not a substrate for P-glycoprotein .
15371980	0	Carbamazepine	0,13	P-glycoprotein	35,49	Carbamazepine	P-glycoprotein	MESH:D002220	5243	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Carbamazepine regulates intestinal P-glycoprotein and multidrug resistance protein MRP2 and influences disposition of talinolol in humans .
24411477	0	Carbamazepine	0,13	P2X4	31,35	Carbamazepine	P2X4	MESH:D002220	5025	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Carbamazepine derivatives with P2X4 receptor-blocking activity .
25026355	0	Carbamazepine	0,13	inducible_nitric_oxide_synthase	25,56	Carbamazepine	inducible nitric oxide synthase	MESH:D002220	4843	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|amod|END_ENTITY	Carbamazepine attenuates inducible_nitric_oxide_synthase expression through Akt inhibition in activated microglial cells .
8042911	0	Carbamazepine	0,13	thyrotropin-releasing_hormone	44,73	Carbamazepine	thyrotropin-releasing hormone	MESH:D002220	7200	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|amod|END_ENTITY	Carbamazepine increases cerebrospinal fluid thyrotropin-releasing_hormone levels in affectively ill patients .
9169082	0	Carbaryl	0,8	CYP1A1	17,23	Carbaryl	CYP1A1	MESH:D012721	1543	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Carbaryl induces CYP1A1 gene expression in HepG2 and HaCaT cells but is not a ligand of the human hepatic Ah_receptor .
23329341	0	Carbetocin	0,10	oxytocin	30,38	Carbetocin	oxytocin	MESH:C020731	5020	Chemical	Gene	START_ENTITY|nmod|comparison comparison|nmod|END_ENTITY	Carbetocin in comparison with oxytocin in several dosing regimens for the prevention of uterine_atony after elective caesarean section in the Netherlands .
25258706	0	Carbimazole	0,11	TNF-a	21,26	Carbimazole	TNF-a	MESH:D002231	103694380	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Carbimazole inhibits TNF-a expression in Fat-induced hypothyroidism .
16897175	0	Carbohydrate	0,12	C-reactive_protein	30,48	Carbohydrate	C-reactive protein	CHEBI:16646	1401	Chemical	Gene	ligands|amod|START_ENTITY ligands|nmod|END_ENTITY	Carbohydrate ligands of human C-reactive_protein : binding of neoglycoproteins containing galactose-6-phosphate and galactose-terminated disaccharide .
2001369	0	Carbohydrate	0,12	CD4	53,56	Carbohydrate	CD4	CHEBI:16646	920	Chemical	Gene	structures|amod|START_ENTITY structures|nmod|END_ENTITY	Carbohydrate structures of recombinant soluble human CD4 expressed in Chinese_hamster_ovary cells .
12324456	1	Carbohydrate	70,82	GP-2	96,100	Carbohydrate	GP-2	CHEBI:16646	531420(Tax:9913)	Chemical	Gene	structure|amod|START_ENTITY structure|nmod|END_ENTITY	Carbohydrate structure of GP-2 , a glycosylphosphatidylinositol-anchored glycoprotein of zymogen granule membranes .
23166201	0	Carbohydrate	73,85	Growth_Hormone	0,14	Carbohydrate	Growth Hormone	CHEBI:16646	2688	Chemical	Gene	Responses|nmod|START_ENTITY Responses|amod|END_ENTITY	Growth_Hormone Responses to Consecutive Exercise Bouts with Ingestion of Carbohydrate plus Protein .
11173618	0	Carbohydrate	10,22	HNK-1	4,9	Carbohydrate	HNK-1	CHEBI:16646	27087	Chemical	Gene	Epitope|compound|START_ENTITY END_ENTITY|dep|Epitope	The HNK-1 Carbohydrate Epitope and the Human Eye in Health and Disease .
8468354	0	Carbohydrate	0,12	HNK-1	105,110	Carbohydrate	HNK-1	CHEBI:16646	76898(Tax:10090)	Chemical	Gene	recognition|amod|START_ENTITY recognition|dep|site site|nmod|glycolipids glycolipids|compound|END_ENTITY	Carbohydrate recognition in the peripheral nervous system : a calcium-dependent membrane binding site for HNK-1 reactive glycolipids potentially involved in Schwann cell adhesion .
3872908	0	Carbohydrate	0,12	IgG2b	23,28	Carbohydrate	IgG2b	CHEBI:16646	16016(Tax:10090)	Chemical	Gene	chains|amod|START_ENTITY chains|nmod|END_ENTITY	Carbohydrate chains on IgG2b : a requirement for efficient feedback immunosuppression .
17132647	0	Carbohydrate	0,12	Insulin	63,70	Carbohydrate	Insulin	CHEBI:16646	3630	Chemical	Gene	nutrition|amod|START_ENTITY nutrition|dep|Resistance Resistance|amod|END_ENTITY	Carbohydrate nutrition , glycaemic load , and plasma lipids : the Insulin Resistance Atherosclerosis Study .
25259787	0	Carbohydrate	0,12	Insulin	163,170	Carbohydrate	Insulin	CHEBI:16646	3630	Chemical	Gene	Measures|compound|START_ENTITY Measures|nmod|EMPOWIR EMPOWIR|dep|Enhance Enhance|dep|Profile Profile|nmod|Resistance Resistance|compound|END_ENTITY	Carbohydrate Modified Diet _ Insulin Sensitizers Reduce Body Weight _ Modulate Metabolic Syndrome Measures in EMPOWIR -LRB- Enhance the Metabolic Profile of Women with Insulin Resistance -RRB- : A Randomized Trial of Normoglycemic Women with Midlife Weight Gain .
25259787	0	Carbohydrate	0,12	Insulin	29,36	Carbohydrate	Insulin	CHEBI:16646	3630	Chemical	Gene	Measures|compound|START_ENTITY Measures|compound|END_ENTITY	Carbohydrate Modified Diet _ Insulin Sensitizers Reduce Body Weight _ Modulate Metabolic Syndrome Measures in EMPOWIR -LRB- Enhance the Metabolic Profile of Women with Insulin Resistance -RRB- : A Randomized Trial of Normoglycemic Women with Midlife Weight Gain .
26230278	0	Carbohydrate	27,39	Insulin	9,16	Carbohydrate	Insulin	CHEBI:16646	3630	Chemical	Gene	Counting|compound|START_ENTITY Dosing|nmod|Counting Dosing|compound|END_ENTITY	Mealtime Insulin Dosing by Carbohydrate Counting in Hospitalized Cardiology Patients : A Retrospective Cohort Study .
26848765	0	Carbohydrate	116,128	Insulin	40,47	Carbohydrate	Insulin	CHEBI:16646	3630	Chemical	Gene	Factors|nmod|START_ENTITY Factors|nsubj|Effect Effect|nmod|Polymorphism Polymorphism|nmod|UCP3 UCP3|nmod|Resistance Resistance|compound|END_ENTITY	Effect of -55 CT Polymorphism of UCP3 on Insulin Resistance and Cardiovascular Risk Factors after a High Protein/Low Carbohydrate versus a Standard Hypocaloric Diet .
25422308	0	Carbohydrate	0,12	Langerin	34,42	Carbohydrate	Langerin	CHEBI:16646	50489	Chemical	Gene	START_ENTITY|dobj|Binding Binding|nmod|END_ENTITY	Carbohydrate Dependent Binding of Langerin to SodC , a Cell Wall Glycoprotein of Mycobacterium_leprae .
9278435	0	Carbohydrate	0,12	alpha-L-iduronidase	45,64	Carbohydrate	alpha-L-iduronidase	CHEBI:16646	100767663	Chemical	Gene	structures|amod|START_ENTITY structures|nmod|END_ENTITY	Carbohydrate structures of recombinant human alpha-L-iduronidase secreted by Chinese_hamster ovary cells .
7679920	0	Carbohydrate	0,12	alpha-fetoprotein	33,50	Carbohydrate	alpha-fetoprotein	CHEBI:16646	174	Chemical	Gene	structures|amod|START_ENTITY structures|nmod|END_ENTITY	Carbohydrate structures of human alpha-fetoprotein of patients with hepatocellular_carcinoma : presence of fucosylated and non-fucosylated triantennary glycans .
14579566	0	Carbohydrate	0,12	annexin_V	33,42	Carbohydrate	annexin V	CHEBI:16646	308	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Carbohydrate binding activity of annexin_V toward a bisecting N-acetylglucosamine .
8243674	0	Carbohydrate	0,12	antithrombin	25,37	Carbohydrate	antithrombin	CHEBI:16646	462	Chemical	Gene	isoforms|amod|START_ENTITY isoforms|nmod|END_ENTITY	Carbohydrate isoforms of antithrombin variant N135Q with different heparin affinities .
7525874	0	Carbohydrate	0,12	beta-trace_protein	27,45	Carbohydrate	beta-trace protein	CHEBI:16646	5730	Chemical	Gene	structures|amod|START_ENTITY structures|nmod|END_ENTITY	Carbohydrate structures of beta-trace_protein from human cerebrospinal fluid : evidence for `` brain-type '' _ N-glycosylation .
3624248	0	Carbohydrate	0,12	erythropoietin	26,40	Carbohydrate	erythropoietin	CHEBI:16646	100753960	Chemical	Gene	structure|amod|START_ENTITY structure|nmod|END_ENTITY	Carbohydrate structure of erythropoietin expressed in Chinese_hamster ovary cells by a human erythropoietin cDNA .
3624248	0	Carbohydrate	0,12	erythropoietin	93,107	Carbohydrate	erythropoietin	CHEBI:16646	2056	Chemical	Gene	structure|amod|START_ENTITY expressed|nsubj|structure expressed|nmod|cDNA cDNA|compound|END_ENTITY	Carbohydrate structure of erythropoietin expressed in Chinese_hamster ovary cells by a human erythropoietin cDNA .
1425441	0	Carbohydrate	0,12	follitropin_receptor	23,43	Carbohydrate	follitropin receptor	CHEBI:16646	281172(Tax:9913)	Chemical	Gene	moiety|amod|START_ENTITY moiety|nmod|END_ENTITY	Carbohydrate moiety of follitropin_receptor is not required for high affinity hormone-binding or for functional coupling between receptor and guanine_nucleotide-binding protein in bovine calf testis membranes .
10690889	0	Carbohydrate	0,12	growth_hormone	41,55	Carbohydrate	growth hormone	CHEBI:16646	2688	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|nmod|treatment treatment|compound|END_ENTITY	Carbohydrate metabolism during long-term growth_hormone -LRB- GH -RRB- treatment and after discontinuation of GH treatment in girls with Turner_syndrome participating in a randomized dose-response study .
10848879	0	Carbohydrate	0,12	growth_hormone	173,187	Carbohydrate	growth hormone	CHEBI:16646	2688	Chemical	Gene	metabolism|amod|START_ENTITY treated|nsubj|metabolism treated|nmod|injections injections|compound|END_ENTITY	Carbohydrate metabolism during growth_hormone treatment and after discontinuation of growth_hormone treatment in girls with Turner_syndrome treated with once or twice daily growth_hormone injections .
10848879	0	Carbohydrate	0,12	growth_hormone	31,45	Carbohydrate	growth hormone	CHEBI:16646	2688	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|nmod|treatment treatment|amod|END_ENTITY	Carbohydrate metabolism during growth_hormone treatment and after discontinuation of growth_hormone treatment in girls with Turner_syndrome treated with once or twice daily growth_hormone injections .
11207640	0	Carbohydrate	0,12	growth_hormone	41,55	Carbohydrate	growth hormone	CHEBI:16646	2688	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|nmod|treatment treatment|compound|END_ENTITY	Carbohydrate metabolism during long-term growth_hormone treatment in children with short_stature born small for gestational age .
12714788	0	Carbohydrate	0,12	growth_hormone	57,71	Carbohydrate	growth hormone	CHEBI:16646	2688	Chemical	Gene	metabolism|amod|START_ENTITY impaired|nsubjpass|metabolism impaired|nmod|years years|nmod|therapy therapy|amod|END_ENTITY	Carbohydrate metabolism is not impaired after 3 years of growth_hormone therapy in children with Prader-Willi_syndrome .
2590120	0	Carbohydrate	0,12	growth_hormone	37,51	Carbohydrate	growth hormone	CHEBI:16646	2688	Chemical	Gene	metabolism|amod|START_ENTITY END_ENTITY|nsubj|metabolism	Carbohydrate metabolism on high dose growth_hormone therapy in children treated for leukaemia .
7476303	0	Carbohydrate	0,12	growth_hormone	35,49	Carbohydrate	growth hormone	CHEBI:16646	2688	Chemical	Gene	START_ENTITY|dobj|metabolism metabolism|nmod|resistance resistance|compound|END_ENTITY	Carbohydrate metabolism in primary growth_hormone resistance -LRB- Laron_syndrome -RRB- before and during insulin-like_growth_factor-I treatment .
8792386	0	Carbohydrate	0,12	growth_hormone	46,60	Carbohydrate	growth hormone	CHEBI:16646	2688	Chemical	Gene	metabolism|amod|START_ENTITY END_ENTITY|nsubj|metabolism	Carbohydrate metabolism in children receiving growth_hormone for 5 years .
9920138	0	Carbohydrate	0,12	growth_hormone	49,63	Carbohydrate	growth hormone	CHEBI:16646	2688	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|nmod|dosing dosing|compound|END_ENTITY	Carbohydrate and lipid metabolism during various growth_hormone dosing regimens in girls with Turner_syndrome .
11302201	0	Carbohydrate	0,12	haptoglobin	27,38	Carbohydrate	haptoglobin	CHEBI:16646	3240	Chemical	Gene	structures|amod|START_ENTITY structures|nmod|END_ENTITY	Carbohydrate structures of haptoglobin in sera of healthy people and a patient with congenital_disorder of glycosylation .
11050690	0	Carbohydrate	0,12	insulin	84,91	Carbohydrate	insulin	CHEBI:16646	396145(Tax:9031)	Chemical	Gene	metabolism|amod|START_ENTITY induced|nsubj|metabolism induced|nmod|infusion infusion|compound|END_ENTITY	Carbohydrate metabolism in temporal and persistent hypoglycemic chickens induced by insulin infusion .
1154133	0	Carbohydrate	0,12	insulin	31,38	Carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	START_ENTITY|dobj|levels levels|compound|END_ENTITY	Carbohydrate tolerance , plasma insulin , growth_hormone and lipid levels in Indian and Black diabetics .
1224616	0	Carbohydrate	1,13	insulin	31,38	Carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	tolerance|compound|START_ENTITY tolerance|appos|END_ENTITY	-LSB- Carbohydrate tolerance , serum insulin and triglycerides in coronary_disease -RSB- .
3044864	0	Carbohydrate	0,12	insulin	45,52	Carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|nmod|END_ENTITY	Carbohydrate metabolism and plasma levels of insulin and glucagon in patients with atherosclerotic_vascular_disease .
5107145	0	Carbohydrate	1,13	insulin	158,165	Carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	metabolism|nsubj|START_ENTITY metabolism|nmod|reference reference|nmod|analysis analysis|nmod|tolerance tolerance|nmod|-RSB- -RSB-|amod|obesity obesity|nmod|standpoint standpoint|nmod|dynamics dynamics|compound|END_ENTITY	-LSB- Carbohydrate metabolism and hormones in obesity -- with special reference to the analysis of reduced glucose tolerance in obesity from the standpoint of serum insulin dynamics -RSB- .
7022110	0	Carbohydrate	0,12	insulin	28,35	Carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	intake|amod|START_ENTITY affects|nsubj|intake affects|dobj|END_ENTITY	Carbohydrate intake affects insulin binding to human erythrocytes in normal weight subjects but not in subjects with family obesity .
8665779	0	Carbohydrate	0,12	insulin	27,34	Carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|nmod|resistance resistance|compound|END_ENTITY	Carbohydrate metabolism in insulin resistance : glucose uptake and lactate production by adipose and forearm tissues in vivo before and after a mixed meal .
936702	0	Carbohydrate	1,13	insulin	40,47	Carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	tolerance|compound|START_ENTITY tolerance|nmod|END_ENTITY	-LSB- Carbohydrate tolerance and behavior of insulin in the glucose infusion test in persons with normal weight with prediabetic suspicion -RSB- .
7476303	0	Carbohydrate	0,12	insulin-like_growth_factor-I	96,124	Carbohydrate	insulin-like growth factor-I	CHEBI:16646	3479	Chemical	Gene	START_ENTITY|nmod|treatment treatment|compound|END_ENTITY	Carbohydrate metabolism in primary growth_hormone resistance -LRB- Laron_syndrome -RRB- before and during insulin-like_growth_factor-I treatment .
11390392	0	Carbohydrate	0,12	interleukin-2	33,46	Carbohydrate	interleukin-2	CHEBI:16646	3558	Chemical	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Carbohydrate recognition site of interleukin-2 in relation to cell proliferation .
14579600	0	Carbohydrate	0,12	interleukin-2	28,41	Carbohydrate	interleukin-2	CHEBI:16646	3558	Chemical	Gene	recognition|amod|START_ENTITY recognition|nmod|END_ENTITY	Carbohydrate recognition of interleukin-2 in cell proliferation .
1783599	0	Carbohydrate	0,12	interleukin_5	33,46	Carbohydrate	interleukin 5	CHEBI:16646	3567	Chemical	Gene	structures|amod|START_ENTITY structures|nmod|END_ENTITY	Carbohydrate structures of human interleukin_5 expressed in Chinese_hamster ovary cells .
7757427	0	Carbohydrate	0,12	lamp-1	47,53	Carbohydrate	lamp-1	CHEBI:16646	3916	Chemical	Gene	structures|amod|START_ENTITY structures|nmod|END_ENTITY	Carbohydrate structures of recombinant soluble lamp-1 and leukosialin containing sialyl_Le -LRB- x -RRB- terminus .
9084976	0	Carbohydrate	0,12	leptin	49,55	Carbohydrate	leptin	CHEBI:16646	3952	Chemical	Gene	intake|amod|START_ENTITY intake|nmod|END_ENTITY	Carbohydrate intake and short-term regulation of leptin in humans .
15044396	0	Carbohydrate	0,12	prostate_specific_antigen	51,76	Carbohydrate	prostate specific antigen	CHEBI:16646	354	Chemical	Gene	structure|amod|START_ENTITY structure|nmod|END_ENTITY	Carbohydrate structure and differential binding of prostate_specific_antigen to Maackia amurensis lectin between prostate_cancer and benign_prostate_hypertrophy .
7248356	0	Carbohydrate	1,13	rhodopsin	47,56	Carbohydrate	rhodopsin	CHEBI:16646	509933(Tax:9913)	Chemical	Gene	composition|compound|START_ENTITY composition|nmod|END_ENTITY	-LSB- Carbohydrate composition of wall-eyed pollock rhodopsin -RSB- .
2226797	0	Carbohydrate	0,12	tissue_plasminogen_activator	35,63	Carbohydrate	tissue plasminogen activator	CHEBI:16646	100128998	Chemical	Gene	structures|amod|START_ENTITY structures|nmod|variant variant|compound|END_ENTITY	Carbohydrate structures of a human tissue_plasminogen_activator variant expressed in recombinant Chinese_hamster ovary cells .
2503511	0	Carbohydrate	0,12	tissue_plasminogen_activator	33,61	Carbohydrate	tissue plasminogen activator	CHEBI:16646	100128998	Chemical	Gene	structures|amod|START_ENTITY structures|nmod|END_ENTITY	Carbohydrate structures of human tissue_plasminogen_activator expressed in Chinese_hamster ovary cells .
2513186	0	Carbohydrate	0,12	tissue_plasminogen_activator	52,80	Carbohydrate	tissue plasminogen activator	CHEBI:16646	100128998	Chemical	Gene	structure|amod|START_ENTITY structure|nmod|END_ENTITY	Carbohydrate structure of recombinant human uterine tissue_plasminogen_activator expressed in mouse epithelial cells .
10846234	0	Carbohydrate	1,13	transferrin	24,35	Carbohydrate	transferrin	CHEBI:16646	7018	Chemical	Gene	deficient|nsubj|START_ENTITY deficient|dobj|END_ENTITY	-LSB- Carbohydrate deficient transferrin : what 's new 20 years later ? -RSB- .
11413989	0	Carbohydrate	1,13	transferrin	24,35	Carbohydrate	transferrin	CHEBI:16646	7018	Chemical	Gene	deficient|nsubj|START_ENTITY deficient|dobj|transferase transferase|compound|END_ENTITY	-LSB- Carbohydrate deficient transferrin , gammaglutamyl transferase and mean corpuscular volume in the evaluation of recent alcohol intake in excessive drinkers -RSB- .
1628603	0	Carbohydrate	0,12	transferrin	25,36	Carbohydrate	transferrin	CHEBI:16646	7018	Chemical	Gene	analysis|amod|START_ENTITY analysis|nmod|subfractions subfractions|compound|END_ENTITY	Carbohydrate analysis of transferrin subfractions isolated by preparative isoelectric focusing in immobilized pH gradients .
3515994	0	Carbohydrate	0,12	transferrin	34,45	Carbohydrate	transferrin	CHEBI:16646	7018	Chemical	Gene	composition|amod|START_ENTITY composition|nmod|END_ENTITY	Carbohydrate composition of serum transferrin in alcoholic patients .
7748277	0	Carbohydrate	0,12	transferrin	23,34	Carbohydrate	transferrin	CHEBI:16646	7018	Chemical	Gene	START_ENTITY|dobj|levels levels|compound|END_ENTITY	Carbohydrate deficient transferrin levels in hazardous alcohol consumption .
7755600	0	Carbohydrate	0,12	transferrin	34,45	Carbohydrate	transferrin	CHEBI:16646	7018	Chemical	Gene	composition|amod|START_ENTITY composition|nmod|END_ENTITY	Carbohydrate composition of serum transferrin isoforms from patients with high alcohol consumption .
14579601	0	Carbohydrate	0,12	vesicular_integral_protein_of_36_kDa	28,64	Carbohydrate	vesicular integral protein of 36 kDa	CHEBI:16646	10960	Chemical	Gene	recognition|amod|START_ENTITY recognition|nmod|END_ENTITY	Carbohydrate recognition of vesicular_integral_protein_of_36_kDa -LRB- ViP36 -RRB- in intracellular transport of newly synthesized glycoproteins .
17747573	0	Carbohydrates	25,38	Cytochrome_c	42,54	Carbohydrates	Cytochrome c	MESH:D002241	54205	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Reduction-like Effect of Carbohydrates on Cytochrome_c .
8875910	0	Carbohydrates	13,26	alpha-Galactosidase	34,53	Carbohydrates	alpha-Galactosidase	MESH:D002241	547845(Tax:3847)	Chemical	Gene	START_ENTITY|nmod|Activity Activity|amod|END_ENTITY	Influence of Carbohydrates on the alpha-Galactosidase Activity of Lactobacillus_fermentum The influence of soybean galactosaccharides -LRB- stachyose , raffinose , melibiose -RRB- as well as galactose and glucose on the synthesis and activity of alpha-galactosidase -LRB- alpha-gal -RRB- from Lactobacillus_fermentum CRL 251 was studied .
26820049	0	Carbon	97,103	Alkaline_Phosphatase	45,65	Carbon	Alkaline Phosphatase	MESH:D002244	250	Chemical	Gene	Activity|nmod|START_ENTITY Activity|compound|END_ENTITY	Facile and Sensitive Fluorescence Sensing of Alkaline_Phosphatase Activity with Photoluminescent Carbon Dots Based on Inner Filter Effect .
11303578	0	Carbon	0,6	CO2	140,143	Carbon	CO2	MESH:D002244	717	Chemical	Gene	assimilation|compound|START_ENTITY pine|nsubj|assimilation pine|nmod|concentrations concentrations|nmod|END_ENTITY	Carbon assimilation and nitrogen in needles of fertilized and unfertilized field-grown Scots pine at natural and elevated concentrations of CO2 .
12228358	0	Carbon	127,133	CO2	38,41	Carbon	CO2	MESH:D002244	717	Chemical	Gene	Quantification|nmod|START_ENTITY Quantification|nmod|Contribution Contribution|nmod|HCO3 HCO3|compound|END_ENTITY	Quantification of the Contribution of CO2 , HCO3 - , and External Carbonic Anhydrase to Photosynthesis at Low Dissolved Inorganic Carbon in Chlorella saccharophila .
15467866	0	Carbon	0,6	CO2	99,102	Carbon	CO2	MESH:D002244	717	Chemical	Gene	nanotube/poly|compound|START_ENTITY nanocomposites|nsubj|nanotube/poly nanocomposites|xcomp|prepared prepared|nmod|aid aid|nmod|END_ENTITY	Carbon nanotube/poly -LRB- 2,4-hexadiyne-1 ,6 - diol -RRB- nanocomposites prepared with the aid of supercritical CO2 .
18070383	0	Carbon	0,6	CO2	67,70	Carbon	CO2	MESH:D002244	717	Chemical	Gene	analysis|compound|START_ENTITY analysis|acl|inspecting inspecting|dobj|carbonation carbonation|nmod|concrete concrete|acl|using using|dobj|plasma plasma|compound|END_ENTITY	Carbon analysis for inspecting carbonation of concrete using a TEA CO2 laser-induced plasma .
20888098	0	Carbon	0,6	CO2	94,97	Carbon	CO2	MESH:D002244	717	Chemical	Gene	isotope|nsubj|START_ENTITY isotope|dobj|signature signature|nmod|dissolved_inorganic_carbon dissolved_inorganic_carbon|nmod|END_ENTITY	Carbon isotope signature of dissolved_inorganic_carbon -LRB- DIC -RRB- in precipitation and atmospheric CO2 .
21401091	0	Carbon	0,6	CO2	67,70	Carbon	CO2	MESH:D002244	717	Chemical	Gene	nanoparticles|nsubj|START_ENTITY nanoparticles|nmod|photocatalysts photocatalysts|nmod|conversion conversion|compound|END_ENTITY	Carbon nanoparticles as visible-light photocatalysts for efficient CO2 conversion and beyond .
22777776	0	Carbon	0,6	CO2	42,45	Carbon	CO2	MESH:D002244	717	Chemical	Gene	characterization|compound|START_ENTITY characterization|nmod|END_ENTITY	Carbon isotopic characterization of cider CO2 by isotope ratio mass spectrometry : a tool for quality and authenticity assessment .
23260380	0	Carbon	0,6	CO2	24,27	Carbon	CO2	MESH:D002244	717	Chemical	Gene	storage|compound|START_ENTITY END_ENTITY|nsubj|storage	Carbon storage and soil CO2 efflux rates at varying degrees of damage from pine_wilt_disease in red pine stands .
24420090	0	Carbon	0,6	CO2	193,196	Carbon	CO2	MESH:D002244	717	Chemical	Gene	START_ENTITY|nsubj|berger berger|appos|plant plant|dep|aspects aspects|acl|related related|nmod|fixation fixation|compound|END_ENTITY	Carbon isotope composition of biochemical fractions isolated from leaves of Bryophyllum daigremontianum berger , a plant with crassulacean_acid metabolism : Some physiological aspects related to CO2 dark fixation .
25137398	0	Carbon	65,71	CO2	0,3	Carbon	CO2	MESH:D002244	717	Chemical	Gene	Management|compound|START_ENTITY Limitations|nmod|Management Implications|nmod|Limitations Deserts|dep|Implications Deserts|compound|END_ENTITY	CO2 Deserts : Implications of Existing CO2 Supply Limitations for Carbon Management .
25137398	0	Carbon	65,71	CO2	38,41	Carbon	CO2	MESH:D002244	717	Chemical	Gene	Management|compound|START_ENTITY Limitations|nmod|Management Limitations|compound|END_ENTITY	CO2 Deserts : Implications of Existing CO2 Supply Limitations for Carbon Management .
25259884	0	Carbon	55,61	CO2	0,3	Carbon	CO2	MESH:D002244	717	Chemical	Gene	Catalyzed|nmod|START_ENTITY Catalyzed|nsubj|Reduction Reduction|compound|END_ENTITY	CO2 Reduction Catalyzed by Mercaptopteridine on Glassy Carbon .
25314144	0	Carbon	0,6	CO2	92,95	Carbon	CO2	MESH:D002244	717	Chemical	Gene	Cycling|compound|START_ENTITY Cycling|dep|Autotrophy Autotrophy|nmod|END_ENTITY	Carbon Cycling of Lake Kivu -LRB- East Africa -RRB- : Net Autotrophy in the Epilimnion and Emission of CO2 to the Atmosphere Sustained by Geogenic Inputs .
25917928	0	Carbon	22,28	CO2	105,108	Carbon	CO2	MESH:D002244	717	Chemical	Gene	Tuning|nmod|START_ENTITY Tuning|dep|Case Case|nmod|Capture Capture|compound|END_ENTITY	Tuning of ZIF-Derived Carbon with High Activity , Nitrogen Functionality , and Yield - A Case for Superior CO2 Capture .
25928139	0	Carbon	76,82	CO2	0,3	Carbon	CO2	MESH:D002244	717	Chemical	Gene	Credits|compound|START_ENTITY Use|nmod|Credits Perspectives|nmod|Use END_ENTITY|dep|Perspectives	CO2 and H2O : Understanding Different Stakeholder Perspectives on the Use of Carbon Credits to Finance Household Water Treatment Projects .
26049445	0	Carbon	68,74	CO2	46,49	Carbon	CO2	MESH:D002244	717	Chemical	Gene	capture|compound|START_ENTITY spectroscopy|dep|capture spectroscopy|nmod|END_ENTITY	Ultrafast vibrational spectroscopy -LRB- 2D-IR -RRB- of CO2 in ionic liquids : Carbon capture from carbon_dioxide 's point of view .
26237131	0	Carbon	21,27	CO2	44,47	Carbon	CO2	MESH:D002244	717	Chemical	Gene	Nanofibers|compound|START_ENTITY Synthesis|nmod|Nanofibers Synthesis|nmod|END_ENTITY	One-Pot Synthesis of Carbon Nanofibers from CO2 .
26286784	0	Carbon	11,17	CO2	41,44	Carbon	CO2	MESH:D002244	717	Chemical	Gene	Nanotube|compound|START_ENTITY Nanotube|nmod|Hydrolysis Hydrolysis|compound|END_ENTITY	Biomimetic Carbon Nanotube for Catalytic CO2 Hydrolysis : First-Principles Investigation on the Role of Oxidation State and Metal Substitution in Porphyrin .
26293492	0	Carbon	81,87	CO2	92,95	Carbon	CO2	MESH:D002244	717	Chemical	Gene	START_ENTITY|nmod|Capture Capture|compound|END_ENTITY	Furfuralcohol Co-Polymerized Urea Formaldehyde Resin-derived N-Doped Microporous Carbon for CO2 Capture .
26356083	0	Carbon	0,6	CO2	54,57	Carbon	CO2	MESH:D002244	717	Chemical	Gene	Composition|compound|START_ENTITY Composition|nmod|END_ENTITY	Carbon Isotope Composition of Nighttime Leaf-Respired CO2 in the Agricultural-Pastoral Zone of the Songnen Plain , Northeast China .
26404732	0	Carbon	15,21	CO2	87,90	Carbon	CO2	MESH:D002244	717	Chemical	Gene	Arrays|compound|START_ENTITY Arrays|nmod|Reduction Reduction|nmod|END_ENTITY	Nitrogen-Doped Carbon Nanotube Arrays for High-Efficiency Electrochemical Reduction of CO2 : On the Understanding of Defects , Defect Density , and Selectivity .
26517749	0	Carbon	141,147	CO2	72,75	Carbon	CO2	MESH:D002244	717	Chemical	Gene	Sequestration|compound|START_ENTITY Implications|nmod|Sequestration Correction|dep|Implications Correction|nmod|Relations Relations|nmod|END_ENTITY	Correction to Capillary Pressure-Saturation Relations for Supercritical CO2 and Brine in Limestone/Dolomite Sands : Implications for Geologic Carbon Sequestration in Carbonate_Reservoirs .
26717034	0	Carbon	21,27	CO2	31,34	Carbon	CO2	MESH:D002244	717	Chemical	Gene	START_ENTITY|nmod|Adsorbent Adsorbent|compound|END_ENTITY	Hierarchical N-Doped Carbon as CO2 Adsorbent with High CO2 Selectivity from Rationally Designed Polypyrrole Precursor .
26717034	0	Carbon	21,27	CO2	55,58	Carbon	CO2	MESH:D002244	717	Chemical	Gene	START_ENTITY|nmod|Selectivity Selectivity|compound|END_ENTITY	Hierarchical N-Doped Carbon as CO2 Adsorbent with High CO2 Selectivity from Rationally Designed Polypyrrole Precursor .
26726618	0	Carbon	14,20	CO2	0,3	Carbon	CO2	MESH:D002244	717	Chemical	Gene	Aerogel|compound|START_ENTITY Aerogel|compound|END_ENTITY	CO2 Activated Carbon Aerogel with Enhanced Electrochemical Performance as a Supercapacitor Electrode Material .
26728638	0	Carbon	0,6	CO2	87,90	Carbon	CO2	MESH:D002244	717	Chemical	Gene	fluxes|compound|START_ENTITY acclimate|nsubj|fluxes acclimate|nmod|concentrations concentrations|compound|END_ENTITY	Carbon fluxes acclimate more strongly to elevated growth temperatures than to elevated CO2 concentrations in a northern conifer .
26835880	0	Carbon	22,28	CO2	76,79	Carbon	CO2	MESH:D002244	717	Chemical	Gene	START_ENTITY|nmod|Reduction Reduction|nmod|END_ENTITY	Metal-free Nanoporous Carbon as a Catalyst for Electrochemical Reduction of CO2 to CO and CH4 .
26836336	0	Carbon	101,107	CO2	121,124	Carbon	CO2	MESH:D002244	717	Chemical	Gene	START_ENTITY|nmod|Capture Capture|compound|END_ENTITY	No More HF : Teflon-Assisted Ultrafast Removal of Silica to Generate High-Surface-Area Mesostructured Carbon for Enhanced CO2 Capture and Supercapacitor Performance .
27001900	0	Carbon	141,147	CO2	37,40	Carbon	CO2	MESH:D002244	717	Chemical	Gene	Layers|compound|START_ENTITY Catalyzed|nmod|Layers Catalyzed|nsubj|Reduction Reduction|compound|END_ENTITY	Surface-Plasmon-Enhanced Photodriven CO2 Reduction Catalyzed by Metal-Organic-Framework-Derived Iron Nanoparticles Encapsulated by Ultrathin Carbon Layers .
8954635	0	Carbon	56,62	Fibrinogen	21,31	Carbon	Fibrinogen	MESH:D002244	2244	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Tenacious Binding of Fibrinogen and Albumin to Pyrolite Carbon and Biomer Adsorption of bovine fibrinogen from dilute plasma and human serum albumin -LRB- HSA -RRB- from buffered HSA solution to low-temperature isotropic -LRB- LTI -RRB- pyrolytic carbon -LRB- Pyrolite -RRB- and polyetherurethane_urea -LRB- Biomer -RRB- was measured .
15975858	0	Carbon	0,6	Gpr1	47,51	Carbon	Gpr1	MESH:D002244	851527(Tax:4932)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|protein protein|amod|END_ENTITY	Carbon source dependent phosphorylation of the Gpr1 protein in the yeast Yarrowia_lipolytica .
8900132	0	Carbon	0,6	PIS1	28,32	Carbon	PIS1	MESH:D002244	856229(Tax:4932)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Carbon source regulation of PIS1 gene expression in Saccharomyces_cerevisiae involves the MCM1 gene and the two-component regulatory gene , SLN1 .
11525404	0	Carbon	0,6	QCR8	58,62	Carbon	QCR8	MESH:D002244	853273(Tax:4932)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|gene gene|compound|END_ENTITY	Carbon source-dependent transcriptional regulation of the QCR8 gene in Kluyveromyces_lactis .
26294425	0	Carbon	14,20	SIRT3	0,5	Carbon	SIRT3	MESH:D002244	23410	Chemical	Gene	Traffic|compound|START_ENTITY Traffic|compound|END_ENTITY	SIRT3 Directs Carbon Traffic in Muscle to Promote Glucose Control .
10656581	0	Carbon	0,6	carbonic_anhydrase	66,84	Carbon	carbonic anhydrase	MESH:D002244	547671(Tax:3847)	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|dep|role role|nmod|END_ENTITY	Carbon metabolism in developing soybean root nodules : the role of carbonic_anhydrase .
10048586	0	Carbon	0,6	protein_kinase_C_epsilon	60,84	Carbon	protein kinase C epsilon	MESH:D002244	18754(Tax:10090)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Carbon source-dependent regulation of cell growth by murine protein_kinase_C_epsilon expression in Saccharomyces_cerevisiae .
25816687	0	Carbon_Monoxide	157,172	Heme_Oxygenase-1	82,98	Carbon Monoxide	Heme Oxygenase-1	MESH:D002248	15368(Tax:10090)	Chemical	Gene	Involvement|nmod|START_ENTITY Upregulation|dep|Involvement Upregulation|nmod|Expression Expression|compound|END_ENTITY	Taurine_Chloramine Stimulates Efferocytosis Through Upregulation of Nrf2-Mediated Heme_Oxygenase-1 Expression in Murine Macrophages : Possible Involvement of Carbon_Monoxide .
26348577	0	Carbon_Monoxide	54,69	Tristetraprolin	0,15	Carbon Monoxide	Tristetraprolin	MESH:D002248	22695(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|compound|END_ENTITY	Tristetraprolin Mediates Anti-Inflammatory Effects of Carbon_Monoxide on Lipopolysaccharide-Induced Acute_Lung_Injury .
26621618	0	Carbon_Nitride	21,35	CO2	93,96	Carbon Nitride	CO2	MESH:C011206	717	Chemical	Gene	START_ENTITY|nmod|Capture Capture|compound|END_ENTITY	Conductive Graphitic Carbon_Nitride as an Ideal Material for Electrocatalytically Switchable CO2 Capture .
18310434	0	Carbon_dioxide	104,118	neurotoxin	29,39	Carbon dioxide	neurotoxin	MESH:D002245	20490862	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Effects of carbon_dioxide on neurotoxin gene expression in nonproteolytic Clostridium_botulinum Type E. Carbon_dioxide is an antimicrobial gas commonly used in modified atmosphere packaging .
104547	0	Carbon_disulphide	0,17	UDP_glucuronosyltransferase	46,73	Carbon disulphide	UDP glucuronosyltransferase	CHEBI:23012	24862(Tax:10116)	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Carbon_disulphide induced activation of liver UDP_glucuronosyltransferase in rats pretreated with phenobarbitone .
21640381	0	Carbon_monoxide	0,15	C-reactive_protein	86,104	Carbon monoxide	C-reactive protein	MESH:D002248	12944(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|nmod|END_ENTITY	Carbon_monoxide , a reaction product of heme_oxygenase-1 , suppresses the expression of C-reactive_protein by endoplasmic reticulum stress through modulation of the unfolded protein response .
17724275	0	Carbon_monoxide	0,15	Ca2	31,34	Carbon monoxide	Ca2	MESH:D002248	760	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Carbon_monoxide stimulates the Ca2 -LRB- + -RRB- - activated big conductance k channels in cultured human endothelial cells .
20442692	0	Carbon_monoxide	0,15	HMGB1	36,41	Carbon monoxide	HMGB1	MESH:D002248	15289(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|release release|compound|END_ENTITY	Carbon_monoxide from CORM-2 reduces HMGB1 release through regulation of IFN-b/JAK2/STAT -1 / INOS/NO signaling but not COX-2 in TLR-activated macrophages .
19524923	0	Carbon_monoxide	0,15	ICAM-1	60,66	Carbon monoxide	ICAM-1	MESH:D002248	3383	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Carbon_monoxide -LRB- from CORM-2 -RRB- inhibits high glucose-induced ICAM-1 expression via AMP-activated_protein_kinase and PPAR-gamma activations in endothelial cells .
16003000	0	Carbon_monoxide	0,15	IL-6	39,43	Carbon monoxide	IL-6	MESH:D002248	3569	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Carbon_monoxide inhibits IL-17-induced IL-6 production through the MAPK pathway in human pulmonary epithelial cells .
15590660	0	Carbon_monoxide	0,15	STAT1	41,46	Carbon monoxide	STAT1	MESH:D002248	6772	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Carbon_monoxide differentially modulates STAT1 and STAT3 and inhibits apoptosis via a phosphatidylinositol 3-kinase/Akt and p38 kinase-dependent STAT3 pathway during anoxia-reoxygenation injury .
20631306	0	Carbon_monoxide	0,15	TLR4	50,54	Carbon monoxide	TLR4	MESH:D002248	21898(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|nmod|END_ENTITY	Carbon_monoxide suppresses membrane expression of TLR4 via myeloid_differentiation_factor-2 in betaTC3 cells .
20840837	0	Carbon_monoxide	0,15	cyclooxygenase-2	24,40	Carbon monoxide	cyclooxygenase-2	MESH:D002248	5743	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Carbon_monoxide induces cyclooxygenase-2 expression through MAPKs and PKG in phagocytes .
14985058	0	Carbon_monoxide	0,15	endothelin-1	25,37	Carbon monoxide	endothelin-1	MESH:D002248	1906	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|amod|END_ENTITY	Carbon_monoxide inhibits endothelin-1 release by human pulmonary artery smooth muscle cells .
12444034	0	Carbon_monoxide	0,15	granulocyte_macrophage_colony-stimulating_factor	58,106	Carbon monoxide	granulocyte macrophage colony-stimulating factor	MESH:D002248	1437	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|production production|nmod|END_ENTITY	Carbon_monoxide modulates endotoxin-induced production of granulocyte_macrophage_colony-stimulating_factor in macrophages .
10564116	0	Carbon_monoxide	0,15	heme_oxygenase-1	32,48	Carbon monoxide	heme oxygenase-1	MESH:D002248	24451(Tax:10116)	Chemical	Gene	overproduced|nsubj|START_ENTITY overproduced|nmod|causes causes|amod|END_ENTITY	Carbon_monoxide overproduced by heme_oxygenase-1 causes a reduction of vascular resistance in perfused rat liver .
11238670	0	Carbon_monoxide	0,15	heme_oxygenase-1	29,45	Carbon monoxide	heme oxygenase-1	MESH:D002248	15368(Tax:10090)	Chemical	Gene	generated|nsubj|START_ENTITY generated|nmod|suppresses suppresses|amod|END_ENTITY	Carbon_monoxide generated by heme_oxygenase-1 suppresses the rejection of mouse-to-rat cardiac transplants .
15067050	0	Carbon_monoxide	0,15	heme_oxygenase-1	28,44	Carbon monoxide	heme oxygenase-1	MESH:D002248	3162	Chemical	Gene	START_ENTITY|acl|produced produced|nmod|suppresses suppresses|amod|END_ENTITY	Carbon_monoxide produced by heme_oxygenase-1 suppresses T cell proliferation via inhibition of IL-2 production .
16625420	0	Carbon_monoxide	0,15	heme_oxygenase-1	35,51	Carbon monoxide	heme oxygenase-1	MESH:D002248	15368(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|suppresses suppresses|amod|END_ENTITY	Carbon_monoxide and bilirubin from heme_oxygenase-1 suppresses reactive oxygen species generation and plasminogen_activator_inhibitor-1 induction .
17681938	0	Carbon_monoxide	0,15	heme_oxygenase-1	28,44	Carbon monoxide	heme oxygenase-1	MESH:D002248	24451(Tax:10116)	Chemical	Gene	START_ENTITY|acl|produced produced|nmod|END_ENTITY	Carbon_monoxide produced by heme_oxygenase-1 in response to nitrosative stress induces expression of glutamate-cysteine ligase in PC12 cells via activation of phosphatidylinositol 3-kinase and Nrf2 signaling .
17823375	0	Carbon_monoxide	0,15	heme_oxygenase-1	24,40	Carbon monoxide	heme oxygenase-1	MESH:D002248	3162	Chemical	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Carbon_monoxide induces heme_oxygenase-1 via activation of protein_kinase_R-like_endoplasmic_reticulum_kinase and inhibits endothelial cell apoptosis triggered by endoplasmic reticulum stress .
20053955	0	Carbon_monoxide	0,15	heme_oxygenase-1	136,152	Carbon monoxide	heme oxygenase-1	MESH:D002248	24451(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|activating activating|dobj|signaling signaling|amod|END_ENTITY	Carbon_monoxide releasing molecule-2 inhibits pancreatic stellate cell proliferation by activating p38_mitogen-activated_protein_kinase / heme_oxygenase-1 signaling .
21640381	0	Carbon_monoxide	0,15	heme_oxygenase-1	39,55	Carbon monoxide	heme oxygenase-1	MESH:D002248	15368(Tax:10090)	Chemical	Gene	START_ENTITY|appos|product product|nmod|END_ENTITY	Carbon_monoxide , a reaction product of heme_oxygenase-1 , suppresses the expression of C-reactive_protein by endoplasmic reticulum stress through modulation of the unfolded protein response .
22145952	0	Carbon_monoxide	0,15	heme_oxygenase-1	30,46	Carbon monoxide	heme oxygenase-1	MESH:D002248	15368(Tax:10090)	Chemical	Gene	START_ENTITY|acl|generated generated|advcl|END_ENTITY	Carbon_monoxide , generated by heme_oxygenase-1 , mediates the enhanced permeability and retention effect in solid tumors .
22593583	0	Carbon_monoxide	0,15	heme_oxygenase-1	55,71	Carbon monoxide	heme oxygenase-1	MESH:D002248	3162	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|dobj|effects effects|nmod|cells cells|amod|END_ENTITY	Carbon_monoxide mediates the anti-apoptotic effects of heme_oxygenase-1 in medulloblastoma DAOY cells via K + channel inhibition .
25072782	0	Carbon_monoxide	0,15	heme_oxygenase-1	24,40	Carbon monoxide	heme oxygenase-1	MESH:D002248	3162	Chemical	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Carbon_monoxide induces heme_oxygenase-1 to modulate STAT3 activation in endothelial cells via S-glutathionylation .
14657222	0	Carbon_monoxide	0,15	heme_oxygenase_1	76,92	Carbon monoxide	heme oxygenase 1	MESH:D002248	15368(Tax:10090)	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|END_ENTITY	Carbon_monoxide protects against liver_failure through nitric_oxide-induced heme_oxygenase_1 .
26435068	0	Carbon_monoxide	0,15	interleukin-1b	26,40	Carbon monoxide	interleukin-1b	MESH:D002248	3553	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|levels levels|amod|END_ENTITY	Carbon_monoxide decreases interleukin-1b levels in the lung through the induction of pyrin .
20860588	0	Carbon_monoxide	0,15	tumor_necrosis_factor-a	57,80	Carbon monoxide	tumor necrosis factor-a	MESH:D002248	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Carbon_monoxide releasing molecule-3 inhibits concurrent tumor_necrosis_factor-a - and interleukin-1b-induced expression of adhesion molecules on human_gingival_fibroblasts .
3787666	0	Carbon_tetrachloride	0,20	cytochrome_P-450	136,152	Carbon tetrachloride	cytochrome P-450	MESH:D002251	25251(Tax:10116)	Chemical	Gene	toxicities|amod|START_ENTITY toxicities|dep|relationship relationship|nmod|level level|nmod|END_ENTITY	Carbon_tetrachloride and trichloroethylene toxicities to rat hepatocytes in primary monolayer culture : its relationship to the level of cytochrome_P-450 .
3947068	0	Carbon_tetrachloride	0,20	cytochrome_P-450	75,91	Carbon tetrachloride	cytochrome P-450	MESH:D002251	25251(Tax:10116)	Chemical	Gene	inactivation|amod|START_ENTITY inactivation|nmod|END_ENTITY	Carbon_tetrachloride and 2-isopropyl-4-pentenamide-induced inactivation of cytochrome_P-450 leads to heme-derived protein adducts .
25082361	0	Carbons	33,40	CO2	106,109	Carbons	CO2	null	717	Chemical	Gene	Synthesis|nmod|START_ENTITY Synthesis|nmod|END_ENTITY	Directed Synthesis of Nanoporous Carbons from Task-Specific Ionic Liquid Precursors for the Adsorption of CO2 .
26114815	0	Carbons	40,47	CO2	69,72	Carbons	CO2	null	717	Chemical	Gene	START_ENTITY|nmod|Capture Capture|compound|END_ENTITY	Hydroquinone and Quinone-Grafted Porous Carbons for Highly Selective CO2 Capture from Flue Gases and Natural Gas Upgrading .
2557899	0	Carbonyldiphosphonate	0,21	DNA_polymerase_delta	58,78	Carbonyldiphosphonate	DNA polymerase delta	MESH:C062324	5424	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Carbonyldiphosphonate , a selective inhibitor of mammalian DNA_polymerase_delta .
26962171	0	Carboplatin	31,42	BRCA2	135,140	Carboplatin	BRCA2	MESH:D016190	675	Chemical	Gene	Response|nmod|START_ENTITY Response|nmod|END_ENTITY	Complete Durable Response From Carboplatin and Olaparib in a Heavily Pretreated Triple-Negative Metastatic Breast_Cancer With Germline BRCA2 and `` BRCAness '' Mutations .
12740905	0	Carboplatin	0,11	CD95	31,35	Carboplatin	CD95	MESH:D016190	355	Chemical	Gene	Fas|compound|START_ENTITY Fas|appos|END_ENTITY	Carboplatin induces Fas -LRB- APO-1 / CD95 -RRB- - dependent apoptosis of human tongue_carcinoma cells : sensitization for apoptosis by upregulation of FADD expression .
2899356	0	Carboxyl	0,8	Gs_alpha	28,36	Carboxyl	Gs alpha	null	2778	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Carboxyl terminal domain of Gs_alpha specifies coupling of receptors to stimulation of adenylyl cyclase .
9774482	0	Carboxyl	0,8	calmodulin	35,45	Carboxyl	calmodulin	null	395855(Tax:9031)	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	Carboxyl methylation of deamidated calmodulin increases its stability in Xenopus oocyte cytoplasm .
11297033	0	Carboxyl	0,8	phospholipase_Cgamma2	36,57	Carboxyl	phospholipase Cgamma2	null	5336	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Carboxyl terminal sequence of human phospholipase_Cgamma2 .
9716267	0	Carboxyl	0,8	rab3D	24,29	Carboxyl	rab3D	null	140665(Tax:10116)	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	Carboxyl methylation of rab3D is developmentally regulated in the rat pancreas : correlation with exocrine function .
11123927	0	Carboxyl	0,8	sulfotransferase	53,69	Carboxyl	sulfotransferase	null	20887(Tax:10090)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Carboxyl residues in the active site of human phenol sulfotransferase -LRB- SULT1A1 -RRB- .
22291761	0	Carboxylic_acid	0,15	histone_deacetylase	31,50	Carboxylic acid	histone deacetylase	CHEBI:33575	9734	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Carboxylic_acid derivatives of histone_deacetylase inhibitors induce full length SMN2 transcripts : a promising target for spinal_muscular_atrophy therapeutics .
25959811	0	Cardamonin	0,10	JNK	69,72	Cardamonin	JNK	MESH:C436747	5599	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|compound|END_ENTITY	Cardamonin induces autophagy and an antiproliferative effect through JNK activation in human colorectal_carcinoma HCT116 cells .
21797841	0	Cardamonin	0,10	TRAIL	38,43	Cardamonin	TRAIL	MESH:C436747	8743	Chemical	Gene	sensitizes|nsubj|START_ENTITY sensitizes|dobj|cells cells|acl|END_ENTITY	Cardamonin sensitizes tumour cells to TRAIL through ROS - and CHOP-mediated up-regulation of death receptors and down-regulation of survival proteins .
23512499	0	Cardamonin	0,10	mTOR	95,99	Cardamonin	mTOR	MESH:C436747	21977(Tax:10090)	Chemical	Gene	ameliorates|nsubj|START_ENTITY ameliorates|dobj|resistance resistance|acl|induced induced|nmod|pathway pathway|compound|END_ENTITY	Cardamonin ameliorates insulin resistance induced by high insulin and high glucose through the mTOR and signal pathway .
26393941	0	Cardamonin	0,10	mTOR	36,40	Cardamonin	mTOR	MESH:C436747	21977(Tax:10090)	Chemical	Gene	Inhibits|compound|START_ENTITY Angiogenesis|nsubj|Inhibits Angiogenesis|nmod|Downregulation Downregulation|compound|END_ENTITY	Cardamonin Inhibits Angiogenesis by mTOR Downregulation in SKOV3 Cells .
26266258	0	Cardamonin	0,10	miR-21	21,27	Cardamonin	miR-21	MESH:C436747	406991	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Cardamonin Regulates miR-21 Expression and Suppresses Angiogenesis Induced by Vascular_Endothelial_Growth_Factor .
25744456	0	Cardenolide_Aglycones	0,21	Intercellular_Adhesion_Molecule-1	76,109	Cardenolide Aglycones	Intercellular Adhesion Molecule-1	null	3383	Chemical	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	Cardenolide_Aglycones Inhibit Tumor_Necrosis_Factor_a-Induced Expression of Intercellular_Adhesion_Molecule-1 at the Translation Step by Blocking Na -LRB- + -RRB- / K -LRB- + -RRB- - ATPase .
26121139	0	Cardiac_Ryanodine	20,37	RyR2	49,53	Cardiac Ryanodine	RyR2	null	20191(Tax:10090)	Chemical	Gene	Receptors|compound|START_ENTITY Receptors|appos|END_ENTITY	Channel Activity of Cardiac_Ryanodine Receptors -LRB- RyR2 -RRB- Determines Potency and Efficacy of Flecainide and R-Propafenone against Arrhythmogenic Calcium Waves in Ventricular Cardiomyocytes .
20193962	0	Cardiolipin	0,11	Bcl-2	51,56	Cardiolipin	Bcl-2	MESH:D002308	596	Chemical	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Cardiolipin , phosphatidylserine , and BH4 domain of Bcl-2 family regulate Ca2 + / H + antiporter activity of human Bax_inhibitor-1 .
26369421	0	Cardiolipin	91,102	Cytochrome_c	42,54	Cardiolipin	Cytochrome c	MESH:D002308	54205	Chemical	Gene	Content|compound|START_ENTITY Liposomes|nmod|Content Coexistence|nmod|Liposomes Coexistence|nmod|END_ENTITY	Coexistence of Native-Like and Non-Native Cytochrome_c on Anionic Liposomes with Different Cardiolipin Content .
16888643	0	Cardiolipin	0,11	cytochrome_c	32,44	Cardiolipin	cytochrome c	MESH:D002308	54205	Chemical	Gene	deficiency|compound|START_ENTITY releases|nsubj|deficiency releases|xcomp|END_ENTITY	Cardiolipin deficiency releases cytochrome_c from the inner mitochondrial membrane and accelerates stimuli-elicited apoptosis .
21600974	0	Carmustine	0,10	ERK	19,22	Carmustine	ERK	MESH:D002330	24338(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Carmustine induces ERK - and JNK-dependent cell death of neuronally-differentiated PC12 cells via generation of reactive oxygen species .
12132580	0	Carnitine	0,9	AGP2	20,24	Carnitine	AGP2	MESH:D002331	852429(Tax:4932)	Chemical	Gene	uptake|amod|START_ENTITY uptake|nmod|END_ENTITY	Carnitine uptake by AGP2 in yeast Saccharomyces_cerevisiae is dependent on Hog1 MAP kinase pathway .
23068102	0	Carnitine	0,9	Bax	117,120	Carnitine	Bax	MESH:D002331	12028(Tax:10090)	Chemical	Gene	sensitizes|nsubj|START_ENTITY sensitizes|nmod|up-regulation up-regulation|nmod|END_ENTITY	Carnitine sensitizes TRAIL-resistant cancer cells to TRAIL-induced apoptotic cell death through the up-regulation of Bax .
10425211	0	Carnitine	0,9	OCTN2	22,27	Carnitine	OCTN2	MESH:D002331	6584	Chemical	Gene	mutations|amod|START_ENTITY mutations|compound|END_ENTITY	Carnitine transporter OCTN2 mutations in systemic primary carnitine_deficiency : a novel Arg169Gln mutation and a recurrent Arg282ter mutation associated with an unconventional splicing abnormality .
15240869	0	Carnitine	0,9	OCTN2	100,105	Carnitine	OCTN2	MESH:D002331	20520(Tax:10090)	Chemical	Gene	content|amod|START_ENTITY content|nmod|enzymes enzymes|nmod|placentas placentas|nmod|wild-type wild-type|dep|END_ENTITY	Carnitine content and expression of mitochondrial beta-oxidation enzymes in placentas of wild-type -LRB- OCTN2 -LRB- + / + -RRB- -RRB- and OCTN2 Null -LRB- OCTN2 -LRB- - / - -RRB- -RRB- Mice .
21169901	0	Carnitine	0,9	Peroxisome_Proliferator-Activated_Receptor-alpha	45,93	Carnitine	Peroxisome Proliferator-Activated Receptor-alpha	MESH:D002331	25747(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Carnitine regulates myocardial metabolism by Peroxisome_Proliferator-Activated_Receptor-alpha -LRB- PPARalpha -RRB- in alcoholic_cardiomyopathy .
8517691	0	Carnitine	0,9	S-1108	52,58	Carnitine	S-1108	MESH:D002331	1077506(Tax:198215)	Chemical	Gene	START_ENTITY|nmod|administration administration|nmod|END_ENTITY	Carnitine status and safety after administration of S-1108 , a new oral cephem , to patients .
9925368	0	Carnitine	0,9	heat_shock_protein	19,37	Carnitine	heat shock protein	MESH:D002331	290549(Tax:10116)	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|synthesis synthesis|compound|END_ENTITY	Carnitine promotes heat_shock_protein synthesis in adriamycin-induced cardiomyopathy in a neonatal rat experimental model .
3651516	0	Carnitine	0,9	milk	32,36	Carnitine	milk	MESH:D002331	100532204	Chemical	Gene	concentrations|amod|START_ENTITY concentrations|nmod|END_ENTITY	Carnitine concentrations in the milk of different species and infant formulas .
25038454	0	Carnosic_acid	0,13	PME-1	71,76	Carnosic acid	PME-1	MESH:C018381	361613(Tax:10116)	Chemical	Gene	uptake|amod|START_ENTITY uptake|nmod|END_ENTITY	Carnosic_acid stimulates glucose uptake in skeletal muscle cells via a PME-1 / PP2A/PKB signalling axis .
10362071	0	Carnosine	0,9	vimentin	21,29	Carnosine	vimentin	MESH:D002336	81818(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	Carnosine stimulates vimentin expression in cultured rat fibroblasts .
16012863	0	Carrageenans	0,12	CD36	86,90	Carrageenans	CD36	CHEBI:3435	948	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|nmod|END_ENTITY	Carrageenans inhibit the in vitro growth of Plasmodium_falciparum and cytoadhesion to CD36 .
19578162	0	Carvacrol	0,9	PPARalpha	47,56	Carvacrol	PPARalpha	MESH:C073316	5465	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Carvacrol , a component of thyme oil , activates PPARalpha and gamma and suppresses COX-2 expression .
15071347	0	Carvedilol	0,10	ACE	41,44	Carvedilol	ACE	MESH:C043211	1636	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	Carvedilol inhibits basal and stimulated ACE production in human endothelial cells .
17438403	0	Carvedilol	0,10	B-type_natriuretic_peptide	28,54	Carvedilol	B-type natriuretic peptide	MESH:C043211	4879	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	Carvedilol reduces elevated B-type_natriuretic_peptide in dialyzed patients without heart_failure : cardioprotective effect of the beta-blocker .
25945865	0	Carvedilol	10,20	Brain_Natriuretic_Peptide	69,94	Carvedilol	Brain Natriuretic Peptide	MESH:C043211	4879	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of Carvedilol on Serum Heart-type_Fatty_Acid-binding_Protein , Brain_Natriuretic_Peptide , and Cardiac Function in Patients With Chronic_Heart_Failure .
25945865	0	Carvedilol	10,20	Brain_Natriuretic_Peptide	69,94	Carvedilol	Brain Natriuretic Peptide	MESH:C043211	4879	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of Carvedilol on Serum Heart-type_Fatty_Acid-binding_Protein , Brain_Natriuretic_Peptide , and Cardiac Function in Patients With Chronic_Heart_Failure .
27093951	0	Carvedilol	11,21	Insulin	47,54	Carvedilol	Insulin	MESH:C043211	3630	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|Resistance Resistance|compound|END_ENTITY	Effects of Carvedilol Compared to Nebivolol on Insulin Resistance and Lipid Profile in Patients With Essential_Hypertension .
15864245	0	Carvedilol	0,10	brain_natriuretic_peptide	61,86	Carvedilol	brain natriuretic peptide	MESH:C043211	4879	Chemical	Gene	therapy|amod|START_ENTITY associated|nsubjpass|therapy associated|nmod|decline decline|nmod|levels levels|amod|END_ENTITY	Carvedilol therapy is associated with a sustained decline in brain_natriuretic_peptide levels in patients with congestive_heart_failure .
15732037	0	Carvedilol	0,10	hypoxia-inducible_factor-1alpha	39,70	Carvedilol	hypoxia-inducible factor-1alpha	MESH:C043211	29560(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	Carvedilol modulates the expression of hypoxia-inducible_factor-1alpha and vascular_endothelial_growth_factor in a rat model of volume-overload_heart_failure .
12167382	0	Carvedilol	0,10	insulin	30,37	Carvedilol	insulin	MESH:C043211	3630	Chemical	Gene	alter|nsubj|START_ENTITY alter|dobj|sensitivity sensitivity|compound|END_ENTITY	Carvedilol does not alter the insulin sensitivity in patients with congestive_heart_failure .
3004419	0	Castanospermine	0,15	glucosidase_I	25,38	Castanospermine	glucosidase I	MESH:C037806	7841	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|compound|END_ENTITY	Castanospermine inhibits glucosidase_I and glycoprotein secretion in human hepatoma cells .
25446583	0	Casticin	0,8	COX-2	18,23	Casticin	COX-2	MESH:C054133	17709(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Casticin inhibits COX-2 and iNOS expression via suppression of NF-kB and MAPK signaling in lipopolysaccharide-stimulated mouse macrophages .
21621513	0	Casuarinin	0,10	ICAM-1	36,42	Casuarinin	ICAM-1	MESH:C472513	3383	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Casuarinin suppresses TNF-a-induced ICAM-1 expression via blockade of NF-kB activation in HaCaT cells .
20123001	0	Catalpol	0,8	MPTP	20,24	Catalpol	MPTP	MESH:C078040	19255(Tax:10090)	Chemical	Gene	attenuates|amod|START_ENTITY END_ENTITY|nsubj|attenuates	Catalpol attenuates MPTP induced neuronal_degeneration of nigral-striatal dopaminergic pathway in mice through elevating glial_cell_derived_neurotrophic_factor in striatum .
26234731	0	Catechin	22,30	NLRP3	103,108	Catechin	NLRP3	MESH:D002392	114548	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|Activation Activation|compound|END_ENTITY	Protective Effects of Catechin against Monosodium_Urate-Induced Inflammation through the Modulation of NLRP3 Inflammasome Activation .
22704780	0	Catechin	0,8	Nrf2	101,105	Catechin	Nrf2	MESH:D002392	4780	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|END_ENTITY	Catechin protects against ketoprofen-induced oxidative damage of the gastric mucosa by up-regulating Nrf2 in vitro and in vivo .
25910046	0	Catechin	0,8	neuraminidase	33,46	Catechin	neuraminidase	MESH:D002392	4758	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	Catechin inhibition of influenza neuraminidase and its molecular basis with mass spectrometry .
25757931	0	Catechins	52,61	Insulin	65,72	Catechins	Insulin	CHEBI:23053	3630	Chemical	Gene	START_ENTITY|nmod|Secretion Secretion|compound|END_ENTITY	Structure-Dependent Inhibitory Effects of Green Tea Catechins on Insulin Secretion from Pancreatic b-Cells .
21305449	0	Catechol	0,8	ICAM-1	79,85	Catechol	ICAM-1	MESH:C034221	3383	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|compound|END_ENTITY	Catechol , a bioactive degradation product of salicortin , reduces TNF-a induced ICAM-1 expression in human endothelial cells .
21305449	0	Catechol	0,8	TNF-a	65,70	Catechol	TNF-a	MESH:C034221	7124	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|amod|END_ENTITY	Catechol , a bioactive degradation product of salicortin , reduces TNF-a induced ICAM-1 expression in human endothelial cells .
20939893	0	Catecholamine	0,13	MMP-7	27,32	Catecholamine	MMP-7	CHEBI:33567	4316	Chemical	Gene	START_ENTITY|dobj|expression expression|compound|END_ENTITY	Catecholamine up-regulates MMP-7 expression by activating AP-1 and STAT3 in gastric_cancer .
11735324	0	Catecholamine	0,13	catechol-o-methyltransferase	68,96	Catecholamine	catechol-o-methyltransferase	CHEBI:33567	1312	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|nmod|brain brain|nmod|END_ENTITY	Catecholamine metabolism in the brain by membrane-bound and soluble catechol-o-methyltransferase -LRB- COMT -RRB- estimated by enzyme kinetic values .
2901433	0	Catecholamine	0,13	corticotropin-releasing_hormone	44,75	Catecholamine	corticotropin-releasing hormone	CHEBI:33567	81648(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	Catecholamine effects upon rat hypothalamic corticotropin-releasing_hormone secretion in vitro .
5409444	0	Catecholamine	0,13	prolactin	28,37	Catecholamine	prolactin	CHEBI:33567	24683(Tax:10116)	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Catecholamine inhibition of prolactin secretion by isolated rat adenohypophyses .
222812	0	Catecholamine	0,13	protein_kinase	55,69	Catecholamine	protein kinase	CHEBI:33567	1022	Chemical	Gene	regulation|amod|START_ENTITY END_ENTITY|nsubj|regulation	Catecholamine regulation of human erythrocyte membrane protein_kinase .
11373471	0	Catecholamines	0,14	interleukin-6	48,61	Catecholamines	interleukin-6	MESH:D002395	16193(Tax:10090)	Chemical	Gene	play|nsubj|START_ENTITY play|dobj|role role|nmod|production production|acl|END_ENTITY	Catecholamines play a role in the production of interleukin-6 and interleukin-1alpha in unburned skin after burn_injury in mice .
11406463	0	Catecholamines	0,14	interleukin-6	25,38	Catecholamines	interleukin-6	MESH:D002395	24498(Tax:10116)	Chemical	Gene	stimulate|nsubj|START_ENTITY stimulate|dobj|synthesis synthesis|amod|END_ENTITY	Catecholamines stimulate interleukin-6 synthesis in rat cardiac fibroblasts .
9663564	0	Catecholamines	0,14	interleukin-6	76,89	Catecholamines	interleukin-6	MESH:D002395	24498(Tax:10116)	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|release release|nmod|cells cells|amod|END_ENTITY	Catecholamines and lipopolysaccharide synergistically induce the release of interleukin-6 from thymic epithelial cells .
11022189	0	Catecholamines	0,14	leptin	24,30	Catecholamines	leptin	MESH:D002395	3952	Chemical	Gene	suppress|nsubj|START_ENTITY suppress|dobj|release release|compound|END_ENTITY	Catecholamines suppress leptin release from in vitro differentiated subcutaneous human adipocytes in primary culture via beta1 - and beta2-adrenergic receptors .
18059019	0	Cathelicidin	0,12	MUC1	65,69	Cathelicidin	MUC1	MESH:C070646	4582	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|END_ENTITY	Cathelicidin stimulates colonic mucus synthesis by up-regulating MUC1 and MUC2 expression through a mitogen-activated protein kinase pathway .
25548223	0	Cathelicidin	25,37	TLR9	47,51	Cathelicidin	TLR9	MESH:C070646	81897(Tax:10090)	Chemical	Gene	Enhances|nsubj|START_ENTITY Enhances|dobj|Activation Activation|compound|END_ENTITY	Endogenous Intracellular Cathelicidin Enhances TLR9 Activation in Dendritic Cells and Macrophages .
25940738	0	Cationic_Titanium_Hydride	45,70	Cp2	95,98	Cationic Titanium Hydride	Cp2	null	1356	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|appos|END_ENTITY	Ligand-Controlled CO2 Activation Mediated by Cationic_Titanium_Hydride Complexes , -LSB- LTiH -RSB- -LRB- + -RRB- -LRB- L = Cp2 , O -RRB- .
9867838	0	Caveolin	0,8	Trk_A	24,29	Caveolin	Trk A	null	59109(Tax:10116)	Chemical	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Caveolin interacts with Trk_A and p75 -LRB- NTR -RRB- and regulates neurotrophin signaling pathways .
12692121	0	Caveolin	0,8	angiotensin_II_type_1_receptor	28,58	Caveolin	angiotensin II type 1 receptor	null	81638(Tax:10116)	Chemical	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Caveolin interacts with the angiotensin_II_type_1_receptor during exocytic transport but not at the plasma membrane .
22671595	0	Caveolin	0,8	claudin-2	32,41	Caveolin	claudin-2	null	9075	Chemical	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Caveolin binds independently to claudin-2 and occludin .
11133013	0	Cavernolide	0,11	sPLA2	38,43	Cavernolide	sPLA2	MESH:C418045	8399	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	Cavernolide : a new inhibitor of human sPLA2 sharing unusual chemical features .
19734122	0	Ccapsaicin	10,20	ENOX2	30,35	Ccapsaicin	ENOX2	null	10495	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of Ccapsaicin on tNOX -LRB- ENOX2 -RRB- protein expression in stomach_cancer cells .
21783713	3	Cd	556,558	Acute_intoxication	524,542	Cd	GSH-Px, GST and GR	null	24404(Tax:10116)	Chemical	Gene	rats|nmod|START_ENTITY END_ENTITY|nmod|rats	Acute_intoxication of rats with Cd were followed by significantly increased activity of antioxidant defense enzymes -LRB- CuZn_SOD , GSH-Px , _ GST_and_GR -RRB- , while the activity of Mn SOD was decreased in the heart .
11502556	0	Cd	33,35	DMT1	15,19	Cd	DMT1	null	4891	Chemical	Gene	uptake|nmod|START_ENTITY END_ENTITY|nmod|uptake	Involvement of DMT1 in uptake of Cd in MDCK cells : role of protein kinase C .
18246773	0	Cd	37,39	glutathione_S-transferase	43,68	Cd	glutathione S-transferase	null	373156	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Short communication direct effect of Cd on glutathione_S-transferase and glutathione_reductase from Calystegia sepium .
9389352	11	CdA	1592,1595	p53	1578,1581	CdA	bax	null	581	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Treatment of CLL cells containing a wild type p53 gene with CdA , F-ara-A , or CLB , did not produce any consistent changes in bax or bcl-2 .
15302099	0	CdCl2	33,38	MKK4	15,19	CdCl2	MKK4	MESH:D019256	26398(Tax:10090)	Chemical	Gene	activation|amod|START_ENTITY Requirement|nmod|activation Requirement|nmod|END_ENTITY	Requirement of MKK4 and MKK7 for CdCl2 - or HgCl2-induced activation of c-Jun NH2-terminal kinase in mouse embryonic stem cells .
26465874	0	CeO2	65,69	CO2	74,77	CeO2	CO2	null	717	Chemical	Gene	START_ENTITY|nmod|capture capture|compound|END_ENTITY	A urea-assisted template method to synthesize mesoporous N-doped CeO2 for CO2 capture .
25147603	0	Cebranopadol	65,77	NOP	32,35	Cebranopadol	NOP	null	4987	Chemical	Gene	Discovery|dep|START_ENTITY Discovery|nmod|END_ENTITY	Discovery of a Potent Analgesic NOP and Opioid Receptor Agonist : Cebranopadol .
26081815	0	Cediranib	103,112	Angiotensin-Converting_Enzyme	0,29	Cediranib	Angiotensin-Converting Enzyme	MESH:C500926	1636	Chemical	Gene	Levels|nmod|START_ENTITY Levels|amod|END_ENTITY	Angiotensin-Converting_Enzyme and Aldosterone Serum Levels as Prognostic and Predictive Biomarkers for Cediranib in NCIC Clinical Trials Group Study BR .24 .
19901116	0	Cediranib	192,201	vascular_endothelial_growth_factor	58,92	Cediranib	vascular endothelial growth factor	MESH:C500926	7422	Chemical	Gene	study|nmod|START_ENTITY strategies|appos|study strategies|nmod|management management|nmod|hypertension hypertension|nmod|END_ENTITY	Effective strategies for management of hypertension after vascular_endothelial_growth_factor signaling inhibition therapy : results from a phase II randomized , factorial , double-blind study of Cediranib in patients with advanced solid tumors .
25343299	0	Cedrol	22,28	Cytochrome_P450	59,74	Cedrol	Cytochrome P450	MESH:C078669	4051	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|Activities Activities|compound|END_ENTITY	Inhibitory Effects of Cedrol , b-Cedrene , and Thujopsene on Cytochrome_P450 Enzyme Activities in Human Liver Microsomes .
6259596	0	Cefotaxime	1,11	CSF	12,15	Cefotaxime	CSF	MESH:D002439	1437	Chemical	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	-LSB- Cefotaxime CSF levels in children with purulent_meningitis -LRB- author 's transl -RRB- -RSB- .
17671744	0	Ceftezole	0,9	alpha-glucosidase	38,55	Ceftezole	alpha-glucosidase	MESH:C012811	69983(Tax:10090)	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|amod|END_ENTITY	Ceftezole , a cephem antibiotic , is an alpha-glucosidase inhibitor with in vivo anti-diabetic activity .
23510201	0	Ceftriaxone	0,11	GLT-1	101,106	Ceftriaxone	GLT-1	MESH:D002443	29482(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|expression expression|nmod|glutamate_transporter glutamate_transporter|appos|END_ENTITY	Ceftriaxone treatment after traumatic_brain_injury restores expression of the glutamate_transporter , GLT-1 , reduces regional gliosis , and reduces post-traumatic seizures in the rat .
24650590	0	Ceftriaxone	0,11	GLT-1	15,20	Ceftriaxone	GLT-1	MESH:D002443	29482(Tax:10116)	Chemical	Gene	START_ENTITY|appos|activator activator|compound|END_ENTITY	Ceftriaxone , a GLT-1 transporter activator , disrupts hippocampal learning in rats .
26002627	0	Ceftriaxone	0,11	GLT-1	116,121	Ceftriaxone	GLT-1	MESH:D002443	29482(Tax:10116)	Chemical	Gene	attenuates|amod|START_ENTITY ethanol|nsubj|attenuates ethanol|nmod|normalization normalization|nmod|END_ENTITY	Ceftriaxone attenuates ethanol drinking and restores extracellular glutamate concentration through normalization of GLT-1 in nucleus accumbens of male alcohol-preferring rats .
22521042	0	Ceftriaxone	0,11	glutamate_transporter	28,49	Ceftriaxone	glutamate transporter	MESH:D002443	29483(Tax:10116)	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	Ceftriaxone upregulates the glutamate_transporter in medial prefrontal cortex and blocks reinstatement of methamphetamine seeking in a condition place preference paradigm .
25891850	0	Celastrol	0,9	FANCD2	45,51	Celastrol	FANCD2	MESH:C050414	2177	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|degradation degradation|nmod|END_ENTITY	Celastrol induces proteasomal degradation of FANCD2 to sensitize lung_cancer cells to DNA crosslinking agents .
19819619	0	Celastrol	0,9	HSP90	19,24	Celastrol	HSP90	MESH:C050414	111058(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Celastrol , a novel HSP90 inhibitor , depletes Bcr-Abl and induces apoptosis in imatinib-resistant chronic_myelogenous_leukemia cells harboring T315I mutation .
20480272	0	Celastrol	0,9	HSP90	72,77	Celastrol	HSP90	MESH:C050414	3320	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|factors factors|acl|belonging belonging|nmod|clients clients|nmod:poss|END_ENTITY	Celastrol regulates multiple nuclear transcription factors belonging to HSP90 's clients in a dose - and cell type-dependent way .
19996313	0	Celastrol	0,9	Hsp90	19,24	Celastrol	Hsp90	MESH:C050414	3320	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|chaperoning chaperoning|amod|END_ENTITY	Celastrol inhibits Hsp90 chaperoning of steroid receptors by inducing fibrillization of the Co-chaperone p23 .
20599745	0	Celastrol	0,9	ICAM-1	39,45	Celastrol	ICAM-1	MESH:C050414	3383	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Celastrol suppresses IFN-gamma-induced ICAM-1 expression and subsequent monocyte adhesiveness via the induction of heme_oxygenase-1 in the HaCaT cells .
23396231	0	Celastrol	0,9	inducible_nitric_oxide_synthase	115,146	Celastrol	inducible nitric oxide synthase	MESH:C050414	4843	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Celastrol , an inhibitor of heat_shock protein 90b potently suppresses the expression of matrix metalloproteinases , inducible_nitric_oxide_synthase and cyclooxygenase-2 in primary human osteoarthritic chondrocytes .
18692027	0	Celecoxib	0,9	5-lipoxygenase	19,33	Celecoxib	5-lipoxygenase	MESH:C105934	240	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Celecoxib inhibits 5-lipoxygenase .
25587329	0	Celecoxib	0,9	ABCG2	65,70	Celecoxib	ABCG2	MESH:C105934	9429	Chemical	Gene	START_ENTITY|dobj|Expression Expression|nmod|END_ENTITY	Celecoxib Up Regulates the Expression of Drug Efflux Transporter ABCG2 in Breast_Cancer Cell Lines .
12657721	0	Celecoxib	0,9	Akt	173,176	Celecoxib	Akt	MESH:C105934	24185(Tax:10116)	Chemical	Gene	acts|nsubj|START_ENTITY acts|xcomp|suppress suppress|nmod|inactivation inactivation|compound|END_ENTITY	Celecoxib acts in a cyclooxygenase-2-independent manner and in synergy with emodin to suppress rat_cholangiocarcinoma growth in vitro through a mechanism involving enhanced Akt inactivation and increased activation of caspases-9_and _ -3 .
16168126	0	Celecoxib	0,9	Akt	28,31	Celecoxib	Akt	MESH:C105934	207	Chemical	Gene	analogues|nsubj|START_ENTITY analogues|xcomp|disrupt disrupt|dobj|signaling signaling|compound|END_ENTITY	Celecoxib analogues disrupt Akt signaling , which is commonly activated in primary breast_tumours .
19201774	0	Celecoxib	0,9	Akt	72,75	Celecoxib	Akt	MESH:C105934	24185(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|inhibition inhibition|nmod|activation activation|compound|END_ENTITY	Celecoxib induces hepatic stellate cell apoptosis through inhibition of Akt activation and suppresses hepatic_fibrosis in rats .
20083195	0	Celecoxib	0,9	Akt	26,29	Celecoxib	Akt	MESH:C105934	207	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Celecoxib activates PI-3K / Akt and mitochondrial redox signaling to enhance heme_oxygenase-1-mediated anti-inflammatory activity in vascular endothelium .
23245395	0	Celecoxib	0,9	CD133	24,29	Celecoxib	CD133	MESH:C105934	8842	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|compound|END_ENTITY	Celecoxib downregulates CD133 expression through inhibition of the Wnt signaling pathway in colon_cancer cells .
10606360	0	Celecoxib	0,9	COX-2	22,27	Celecoxib	COX-2	MESH:C105934	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Celecoxib , a specific COX-2 inhibitor , has no significant effect on methotrexate pharmacokinetics in patients with rheumatoid_arthritis .
11965228	0	Celecoxib	0,9	COX-2	22,27	Celecoxib	COX-2	MESH:C105934	4513	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Celecoxib : a specific COX-2 inhibitor with anticancer properties .
12861847	0	Celecoxib	0,9	COX-2	30,35	Celecoxib	COX-2	MESH:C105934	4513	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Celecoxib , a highly selective COX-2 inhibitor , is safe in aspirin-induced asthma patients .
14729583	0	Celecoxib	0,9	COX-2	55,60	Celecoxib	COX-2	MESH:C105934	5743	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Celecoxib inhibits phorbol_ester-induced expression of COX-2 and activation of AP-1 and p38 MAP kinase in mouse skin .
16709027	1	Celecoxib	143,152	COX-2	214,219	Celecoxib	COX-2	MESH:C105934	4513	Chemical	Gene	appears|nsubj|START_ENTITY appears|xcomp|unique unique|nmod|class class|nmod|inhibitors inhibitors|compound|END_ENTITY	Celecoxib -LRB- Celebrex -RRB- appears to be unique among the class of selective COX-2 inhibitors -LRB- coxibs -RRB- , because this particular compound exerts a second function that is independent of its celebrated ability to inhibit COX-2 .
17027257	0	Celecoxib	111,120	COX-2	95,100	Celecoxib	COX-2	MESH:C105934	5743	Chemical	Gene	START_ENTITY|nsubj|study study|nmod|efficacy efficacy|nmod|combination combination|nmod|Exemestane Exemestane|nmod|inhibitor inhibitor|compound|END_ENTITY	A feasibility study of the efficacy and tolerability of the combination of Exemestane with the COX-2 inhibitor Celecoxib in post-menopausal patients with advanced_breast_cancer .
17257745	0	Celecoxib	0,9	COX-2	31,36	Celecoxib	COX-2	MESH:C105934	4513	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|apoptosis apoptosis|nmod|cells cells|amod|deficient deficient|amod|END_ENTITY	Celecoxib induces apoptosis in COX-2 deficient human gastric_cancer cells through Akt/GSK3beta/NAG -1 pathway .
18230053	0	Celecoxib	0,9	COX-2	28,33	Celecoxib	COX-2	MESH:C105934	4513	Chemical	Gene	analogs|amod|START_ENTITY analogs|dep|function function|nsubj|END_ENTITY	Celecoxib analogs that lack COX-2 inhibitory function : preclinical development of novel anticancer drugs .
19506872	0	Celecoxib	0,9	COX-2	56,61	Celecoxib	COX-2	MESH:C105934	29527(Tax:10116)	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|nmod|mechanism mechanism|compound|END_ENTITY	Celecoxib prevents tumor growth in an animal model by a COX-2 independent mechanism .
24462674	0	Celecoxib	0,9	COX-2	98,103	Celecoxib	COX-2	MESH:C105934	29527(Tax:10116)	Chemical	Gene	offsets|nsubj|START_ENTITY offsets|dobj|influences influences|nmod|cyclosporine cyclosporine|nmod|modulation modulation|nmod|cascade cascade|amod|TGF-b1 TGF-b1|dep|END_ENTITY	Celecoxib offsets the negative renal influences of cyclosporine via modulation of the TGF-b1 / IL-2 / COX-2 / endothelin ET -LRB- B -RRB- receptor cascade .
26095375	0	Celecoxib	72,81	COX-2	37,42	Celecoxib	COX-2	MESH:C105934	5743	Chemical	Gene	using|nsubj|START_ENTITY Understanding|advcl|using Understanding|dobj|inhibition inhibition|nmod|END_ENTITY	Understanding the dual inhibition of COX-2 and Carbonic_anhydrase-II by Celecoxib and CG100649 using Density functional theory calculations and other Molecular Modelling approaches .
26954392	0	Celecoxib	0,9	COX-2	13,18	Celecoxib	COX-2	MESH:C105934	19225(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Celecoxib , a COX-2 inhibitor , synergistically potentiates the anti-inflammatory activity of docosahexaenoic_acid in macrophage cell line .
18197403	0	Celecoxib	0,9	CYP1A2	15,21	Celecoxib	CYP1A2	MESH:C105934	1544	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|compound|END_ENTITY	Celecoxib is a CYP1A2 inhibitor in vitro but not in vivo .
25779473	0	Celecoxib	53,62	Cyclooxygenase-2	76,92	Celecoxib	Cyclooxygenase-2	MESH:C105934	29527(Tax:10116)	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|compound|END_ENTITY	Assessment of the Potential Ototoxicity of High-Dose Celecoxib , a Selective Cyclooxygenase-2 Inhibitor , in Rats .
26728412	0	Celecoxib	101,110	Cyclooxygenase-2	123,139	Celecoxib	Cyclooxygenase-2	MESH:C105934	29527(Tax:10116)	Chemical	Gene	Growth|nmod|START_ENTITY Growth|dep|Effects Effects|nmod|END_ENTITY	Retraction : Suppression of N-Methyl-N-nitrosourea / Testosterone-Induced Rat Prostate_Cancer Growth by Celecoxib : Effects on Cyclooxygenase-2 , Cell Cycle Regulation , and Apoptosis Mechanism -LRB- s -RRB- .
20717005	0	Celecoxib	0,9	ERK	64,67	Celecoxib	ERK	MESH:C105934	5594	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|activation activation|nmod|END_ENTITY	Celecoxib inhibits cell proliferation through the activation of ERK and p38 MAPK in head_and_neck_squamous_cell_carcinoma cell lines .
19685055	0	Celecoxib	0,9	MDR1	19,23	Celecoxib	MDR1	MESH:C105934	5243	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Celecoxib inhibits MDR1 expression through COX-2-dependent mechanism in human hepatocellular_carcinoma -LRB- HepG2 -RRB- cell line .
24721996	0	Celecoxib	0,9	PTEN	72,76	Celecoxib	PTEN	MESH:C105934	50557(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	Celecoxib suppresses hepatoma_stemness and progression by up-regulating PTEN .
23656793	0	Celecoxib	0,9	SMN	20,23	Celecoxib	SMN	MESH:C105934	20595(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Celecoxib increases SMN and survival in a severe spinal_muscular_atrophy mouse model via p38 pathway activation .
20145537	0	Celecoxib	0,9	Stat5	20,25	Celecoxib	Stat5	MESH:C105934	24918(Tax:10116)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Celecoxib activates Stat5 and restores or increases the expression of growth hormone-regulated genes in hepatocarcinogenesis .
21567098	0	Celecoxib	0,9	VEGF	81,85	Celecoxib	VEGF	MESH:C105934	7422	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|apoptosis apoptosis|acl|coupled coupled|nmod|up-regulation up-regulation|nmod|expression expression|nmod|END_ENTITY	Celecoxib induces cell apoptosis coupled with up-regulation of the expression of VEGF by a mechanism involving ER stress in human colorectal_cancer cells .
26931344	0	Celecoxib	0,9	VEGF	45,49	Celecoxib	VEGF	MESH:C105934	7422	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Celecoxib induces apoptosis but up-regulates VEGF via endoplasmic reticulum stress in human colorectal_cancer in vitro and in vivo .
19806804	0	Celecoxib	30,39	bcl-2	57,62	Celecoxib	bcl-2	MESH:C105934	24224(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of dietary and topical Celecoxib on expression of bcl-2 , bax , c-erb-B2 and Ki67 in carcinogen-induced tongue_carcinoma in rat .
12811211	0	Celecoxib	0,9	cox-2	79,84	Celecoxib	cox-2	MESH:C105934	4513	Chemical	Gene	esophagitis|amod|START_ENTITY esophagitis|dep|review review|nmod|effects effects|nmod|inhibitors inhibitors|amod|END_ENTITY	Celecoxib associated esophagitis : review of gastrointestinal side effects from cox-2 inhibitors .
11716847	0	Celecoxib	0,9	cyclo-oxygenase-2	23,40	Celecoxib	cyclo-oxygenase-2	MESH:C105934	29527(Tax:10116)	Chemical	Gene	reduces|advmod|START_ENTITY reduces|nsubj|inhibitor inhibitor|amod|END_ENTITY	Celecoxib , a selective cyclo-oxygenase-2 inhibitor reduces the severity of experimental colitis induced by dinitrobenzene_sulfonic_acid in rats .
10509845	0	Celecoxib	0,9	cyclooxygenase-2	23,39	Celecoxib	cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Celecoxib , a selective cyclooxygenase-2 inhibitor for the treatment of rheumatoid_arthritis and osteoarthritis .
11032948	0	Celecoxib	31,40	cyclooxygenase-2	44,60	Celecoxib	cyclooxygenase-2	MESH:C105934	29527(Tax:10116)	Chemical	Gene	evaluation|nmod|START_ENTITY evaluation|appos|inhibitor inhibitor|amod|END_ENTITY	Chemotherapeutic evaluation of Celecoxib , a cyclooxygenase-2 inhibitor , in a rat mammary tumor model .
12504784	0	Celecoxib	0,9	cyclooxygenase-2	23,39	Celecoxib	cyclooxygenase-2	MESH:C105934	29527(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Celecoxib , a selective cyclooxygenase-2 inhibitor , inhibits retinal_vascular_endothelial_growth_factor expression and vascular_leakage in a streptozotocin-induced diabetic rat model .
14555502	0	Celecoxib	0,9	cyclooxygenase-2	38,54	Celecoxib	cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|marker marker|amod|END_ENTITY	Celecoxib modulates the expression of cyclooxygenase-2 , ki67 , apoptosis-related marker , and microvessel density in human cervical_cancer : a pilot study .
15068837	0	Celecoxib	0,9	cyclooxygenase-2	20,36	Celecoxib	cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Celecoxib : a potent cyclooxygenase-2 inhibitor in cancer prevention .
15238462	0	Celecoxib	0,9	cyclooxygenase-2	13,29	Celecoxib	cyclooxygenase-2	MESH:C105934	29527(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Celecoxib , a cyclooxygenase-2 inhibitor , reduces neointimal hyperplasia through inhibition of Akt signaling .
15613981	0	Celecoxib	0,9	cyclooxygenase-2	23,39	Celecoxib	cyclooxygenase-2	MESH:C105934	100009248(Tax:9986)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Celecoxib , a selective cyclooxygenase-2 inhibitor , decreases monocyte_chemoattractant_protein-1 expression and neointimal hyperplasia in the rabbit atherosclerotic_balloon_injury model .
16023763	0	Celecoxib	0,9	cyclooxygenase-2	13,29	Celecoxib	cyclooxygenase-2	MESH:C105934	29527(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Celecoxib , a cyclooxygenase-2 inhibitor , prevents induction of liver preneoplastic_lesions in rats .
16507390	0	Celecoxib	0,9	cyclooxygenase-2	105,121	Celecoxib	cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	induces|nsubj|START_ENTITY induces|xcomp|independent independent|nmod|expression expression|amod|END_ENTITY	Celecoxib induces dose dependent growth inhibition in nasopharyngeal_carcinoma cell lines independent of cyclooxygenase-2 expression .
16677697	0	Celecoxib	94,103	cyclooxygenase-2	67,83	Celecoxib	cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	START_ENTITY|nsubj|trial trial|nmod|inhibitor inhibitor|amod|END_ENTITY	A randomized double-blind placebo-controlled phase II trial of the cyclooxygenase-2 inhibitor Celecoxib in the treatment of cervical_dysplasia .
16917206	0	Celecoxib	0,9	cyclooxygenase-2	49,65	Celecoxib	cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	induce|nsubj|START_ENTITY induce|nmod|species species|compound|END_ENTITY	Celecoxib can induce cell death independently of cyclooxygenase-2 , p53 , Mdm2 , c-Abl and reactive oxygen species .
18078766	0	Celecoxib	0,9	cyclooxygenase-2	13,29	Celecoxib	cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Celecoxib , a cyclooxygenase-2 inhibitor , induces apoptosis in human osteosarcoma cell line MG-63 via down-regulation of PI3K/Akt .
18523723	0	Celecoxib	0,9	cyclooxygenase-2	33,49	Celecoxib	cyclooxygenase-2	MESH:C105934	29527(Tax:10116)	Chemical	Gene	START_ENTITY|xcomp|retrograde_amnesia retrograde_amnesia|nsubj|an an|nmod|probe probe|nmod|mechanisms mechanisms|amod|END_ENTITY	Celecoxib as an in vivo probe of cyclooxygenase-2 mechanisms underlying retrograde_amnesia in an animal model of ECT .
21245739	0	Celecoxib	0,9	cyclooxygenase-2	51,67	Celecoxib	cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	impairs|nsubj|START_ENTITY impairs|dobj|development development|acl|inhibiting inhibiting|dobj|activity activity|amod|END_ENTITY	Celecoxib impairs heart development via inhibiting cyclooxygenase-2 activity in zebrafish embryos .
21893983	0	Celecoxib	0,9	cyclooxygenase-2	23,39	Celecoxib	cyclooxygenase-2	MESH:C105934	29527(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Celecoxib , a selective cyclooxygenase-2 inhibitor , attenuates renal_injury in a rat model of Cisplatin-induced nephrotoxicity .
21904784	0	Celecoxib	0,9	cyclooxygenase-2	13,29	Celecoxib	cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Celecoxib , a cyclooxygenase-2 inhibitor , improved upper gastrointestinal_lesions in rheumatoid_arthritis patients as assessed by endoscopic evaluation .
22168377	0	Celecoxib	0,9	cyclooxygenase-2	23,39	Celecoxib	cyclooxygenase-2	MESH:C105934	29527(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Celecoxib , a selective cyclooxygenase-2 inhibitor , lowers plasma cholesterol and attenuates hepatic lipid peroxidation during carbon-tetrachloride-associated hepatotoxicity in rats .
22305971	0	Celecoxib	0,9	cyclooxygenase-2	13,29	Celecoxib	cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Celecoxib , a cyclooxygenase-2 inhibitor , potentiates the chemotherapic effect of vinorelbine in the medullary_thyroid_cancer TT cell line .
22441428	0	Celecoxib	45,54	cyclooxygenase-2	68,84	Celecoxib	cyclooxygenase-2	MESH:C105934	29527(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Dolastatin 15 , a mollusk linear peptide , and Celecoxib , a selective cyclooxygenase-2 inhibitor , prevent preneoplastic colonic_lesions and induce apoptosis through inhibition of the regulatory transcription factor NF-kB and an inflammatory protein , iNOS .
24472266	0	Celecoxib	0,9	cyclooxygenase-2	23,39	Celecoxib	cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Celecoxib , a selective cyclooxygenase-2 inhibitor , reduces level of a bone resorption marker in postmenopausal women with rheumatoid_arthritis .
24607877	0	Celecoxib	0,9	cyclooxygenase-2	47,63	Celecoxib	cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	analogs|amod|START_ENTITY analogs|acl|bearing bearing|nmod|inhibitors inhibitors|amod|END_ENTITY	Celecoxib analogs bearing benzofuran moiety as cyclooxygenase-2 inhibitors : design , synthesis and evaluation as potential anti-inflammatory agents .
26407653	0	Celecoxib	0,9	cyclooxygenase-2	115,131	Celecoxib	cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	enhanced|nsubj|START_ENTITY enhanced|nmod|inhibition inhibition|nmod|END_ENTITY	Celecoxib enhanced the cytotoxic effect of cisplatin in drug-resistant human gastric_cancer cells by inhibition of cyclooxygenase-2 .
12056955	0	Celecoxib	0,9	cyclooxygenase_2	13,29	Celecoxib	cyclooxygenase 2	MESH:C105934	19225(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Celecoxib , a cyclooxygenase_2 inhibitor as a potential chemopreventive to UV-induced skin_cancer : a study in the hairless mouse model .
12359744	0	Celecoxib	0,9	cyclooxygenase_2	23,39	Celecoxib	cyclooxygenase 2	MESH:C105934	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Celecoxib , a selective cyclooxygenase_2 inhibitor , protects against human epidermal_growth_factor_receptor_2 -LRB- HER-2 -RRB- / neu-induced breast_cancer .
15953441	0	Celecoxib	0,9	cyclooxygenase_2	36,52	Celecoxib	cyclooxygenase 2	MESH:C105934	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Celecoxib , a selective inhibitor of cyclooxygenase_2 for therapy of diffuse_anterior_scleritis .
12359744	0	Celecoxib	0,9	epidermal_growth_factor_receptor_2	74,108	Celecoxib	epidermal growth factor receptor 2	MESH:C105934	2064	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|END_ENTITY	Celecoxib , a selective cyclooxygenase_2 inhibitor , protects against human epidermal_growth_factor_receptor_2 -LRB- HER-2 -RRB- / neu-induced breast_cancer .
21174079	0	Celecoxib	0,9	heme_oxygenase-1	18,34	Celecoxib	heme oxygenase-1	MESH:C105934	24451(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Celecoxib induces heme_oxygenase-1 expression in macrophages and vascular smooth muscle cells via ROS-dependent signaling pathway .
12902846	0	Celecoxib	0,9	interleukin_10	79,93	Celecoxib	interleukin 10	MESH:C105934	16153(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Celecoxib and rofecoxib potentiate chronic_colitis and premalignant changes in interleukin_10 knockout mice .
18552508	0	Celecoxib	0,9	matrix_metalloproteinase-10	43,70	Celecoxib	matrix metalloproteinase-10	MESH:C105934	4319	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Celecoxib inhibits serum_amyloid_a-induced matrix_metalloproteinase-10 expression in human endothelial cells .
15613981	0	Celecoxib	0,9	monocyte_chemoattractant_protein-1	61,95	Celecoxib	monocyte chemoattractant protein-1	MESH:C105934	100009130(Tax:9986)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|amod|END_ENTITY	Celecoxib , a selective cyclooxygenase-2 inhibitor , decreases monocyte_chemoattractant_protein-1 expression and neointimal hyperplasia in the rabbit atherosclerotic_balloon_injury model .
16172791	0	Celecoxib	0,9	urokinase-type_plasminogen_activator	19,55	Celecoxib	urokinase-type plasminogen activator	MESH:C105934	5328	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Celecoxib inhibits urokinase-type_plasminogen_activator -LRB- uPA -RRB- production in MDA-MB-231 breast_cancer cells .
15026340	0	Celecoxib	0,9	vascular_endothelial_growth_factor	19,53	Celecoxib	vascular endothelial growth factor	MESH:C105934	7422	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Celecoxib inhibits vascular_endothelial_growth_factor expression in and reduces angiogenesis and metastasis of human pancreatic_cancer via suppression of Sp1 transcription factor activity .
21220497	0	Celecoxib	0,9	vascular_endothelial_growth_factor	21,55	Celecoxib	vascular endothelial growth factor	MESH:C105934	7422	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|compound|END_ENTITY	Celecoxib can induce vascular_endothelial_growth_factor expression and tumor angiogenesis .
25333891	0	Celecoxib	0,9	vascular_endothelial_growth_factor	78,112	Celecoxib	vascular endothelial growth factor	MESH:C105934	22339(Tax:10090)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|advcl|modulating modulating|dobj|expression expression|nmod|END_ENTITY	Celecoxib attenuates cachectic events in mice by modulating the expression of vascular_endothelial_growth_factor .
2908816	0	Celiprolol	0,10	beta_1-adrenoceptor	37,56	Celiprolol	beta 1-adrenoceptor	MESH:D017272	24925(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Celiprolol , a potent cardioselective beta_1-adrenoceptor antagonist with mild alpha 2-adrenoceptor antagonist properties .
24918055	0	Centrins	178,186	XPC	96,99	Centrins	XPC	null	7508	Chemical	Gene	START_ENTITY|amod|binding binding|nmod|END_ENTITY	CK2 phosphorylation of human centrins_1_and_2 regulates their binding to the DNA repair protein XPC , the centrosomal protein Sfi1 and the phototransduction protein transducin b. Centrins are calcium-binding proteins that can interact with several cellular targets -LRB- Sfi1 , XPC , Sac3 and transducin b -RRB- through the same hydrophobic triad .
20412118	0	Cepharanthine	0,13	NF-kappaB	76,85	Cepharanthine	NF-kappaB	MESH:C006947	4790	Chemical	Gene	exerts|nsubj|START_ENTITY exerts|nmod|END_ENTITY	Cepharanthine exerts antitumor activity on cholangiocarcinoma by inhibiting NF-kappaB .
25256104	0	Ceramide	50,58	CERT	24,28	Ceramide	CERT	CHEBI:17761	10087	Chemical	Gene	Inhibitors|compound|START_ENTITY Ligands|nmod|Inhibitors Ligands|nsubj|Identification Identification|nmod|END_ENTITY	Identification of Novel CERT Ligands as Potential Ceramide Trafficking Inhibitors .
11062012	0	Ceramide	0,8	COX-2	22,27	Ceramide	COX-2	CHEBI:17761	4513	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Ceramide induction of COX-2 and PGE -LRB- 2 -RRB- in pulmonary A549 cells does not involve activation of NF-kappaB .
26318452	0	Ceramide	67,75	Focal_Adhesion_Kinase	104,125	Ceramide	Focal Adhesion Kinase	CHEBI:17761	14083(Tax:10090)	Chemical	Gene	Loss|compound|START_ENTITY Loss|nmod|END_ENTITY	Tumor_Necrosis_Factor_alpha -LRB- TNFa -RRB- - induced Ceramide Generation via Ceramide Synthases Regulates Loss of Focal_Adhesion_Kinase -LRB- FAK -RRB- and Programmed Cell Death .
8621602	1	Ceramide	128,136	IL-1_beta	146,155	Ceramide	IL-1 beta	CHEBI:17761	3553	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|action action|compound|END_ENTITY	Ceramide enhances IL-1_beta action , but is not sufficient for E-selectin expression .
16477014	0	Ceramide	0,8	IL-1beta	57,65	Ceramide	IL-1beta	CHEBI:17761	3553	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Ceramide mediates the rapid phase of febrile response to IL-1beta .
15322180	0	Ceramide	0,8	IL-2	18,22	Ceramide	IL-2	CHEBI:17761	3558	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	Ceramide inhibits IL-2 production by preventing protein_kinase_C-dependent NF-kappaB activation : possible role in protein_kinase_Ctheta regulation .
17458900	0	Ceramide	0,8	IL-5	44,48	Ceramide	IL-5	CHEBI:17761	16191(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|nmod|END_ENTITY	Ceramide inhibits LPS-induced production of IL-5 , IL-10 , and IL-13 from mast cells .
18820034	0	Ceramide	0,8	JNK	19,22	Ceramide	JNK	CHEBI:17761	5599	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Ceramide activates JNK to inhibit a cAMP-gated K + conductance and Cl - secretion in intestinal epithelia .
18598724	0	Ceramide	0,8	MMP-2	23,28	Ceramide	MMP-2	CHEBI:17761	4313	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|expression expression|compound|END_ENTITY	Ceramide inhibition of MMP-2 expression and human cancer bronchial cell invasiveness involve decreased histone acetylation .
11062012	0	Ceramide	0,8	NF-kappaB	94,103	Ceramide	NF-kappaB	CHEBI:17761	4790	Chemical	Gene	induction|amod|START_ENTITY involve|nsubj|induction involve|dobj|activation activation|nmod|END_ENTITY	Ceramide induction of COX-2 and PGE -LRB- 2 -RRB- in pulmonary A549 cells does not involve activation of NF-kappaB .
15322180	0	Ceramide	0,8	NF-kappaB	75,84	Ceramide	NF-kappaB	CHEBI:17761	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|preventing preventing|dobj|activation activation|amod|END_ENTITY	Ceramide inhibits IL-2 production by preventing protein_kinase_C-dependent NF-kappaB activation : possible role in protein_kinase_Ctheta regulation .
9624136	0	Ceramide	0,8	NFkappaB	19,27	Ceramide	NFkappaB	CHEBI:17761	4790	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Ceramide activates NFkappaB by inducing the processing of p105 .
25347576	0	Ceramide	38,46	Neutral_Sphingomyelinase_2	62,88	Ceramide	Neutral Sphingomyelinase 2	CHEBI:17761	55512	Chemical	Gene	Generation|compound|START_ENTITY Generation|nmod|END_ENTITY	Src Regulates Cigarette Smoke-Induced Ceramide Generation via Neutral_Sphingomyelinase_2 in the Airway Epithelium .
10830777	0	Ceramide	0,8	PC3	72,75	Ceramide	PC3	CHEBI:17761	5122	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Ceramide induces cell death in the human prostatic_carcinoma cell lines PC3 and DU145 but does not seem to be involved in Fas-mediated apoptosis .
26798039	0	Ceramide	0,8	PKC	18,21	Ceramide	PKC	CHEBI:17761	5588	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Ceramide inhibits PKC by regulating its phosphorylation and translocation to lipid rafts in Jurkat cells .
21490809	0	Ceramide	82,90	Pc_4	34,38	Ceramide	Pc 4	CHEBI:17761	18551(Tax:10090)	Chemical	Gene	Accumulation|compound|START_ENTITY Accumulation|compound|END_ENTITY	C16-Ceramide Analog Combined with Pc_4 Photodynamic Therapy Evokes Enhanced Total Ceramide Accumulation , Promotion of DEVDase Activation in the Absence of Apoptosis , and Augmented Overall Cell Killing .
17223929	0	Ceramide	0,8	TLR4	14,18	Ceramide	TLR4	CHEBI:17761	7099	Chemical	Gene	START_ENTITY|nmod|agonist agonist|compound|END_ENTITY	Ceramide as a TLR4 agonist ; a putative signalling intermediate between sphingolipid receptors for microbial ligands and TLR4 .
11259399	0	Ceramide	0,8	aSMase	17,23	Ceramide	aSMase	CHEBI:17761	6609	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Ceramide induces aSMase expression : implications for oxLDL-induced apoptosis .
12208520	0	Ceramide	0,8	acidic_sphingomyelinase	22,45	Ceramide	acidic sphingomyelinase	CHEBI:17761	6609	Chemical	Gene	START_ENTITY|acl|generated generated|nmod|END_ENTITY	Ceramide generated by acidic_sphingomyelinase contributes to tumor_necrosis_factor-alpha-mediated apoptosis in human colon HT-29 cells through glycosphingolipids formation .
12890677	0	Ceramide	0,8	apolipoprotein_A-I	40,58	Ceramide	apolipoprotein A-I	CHEBI:17761	100772590	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|advcl|END_ENTITY	Ceramide enhances cholesterol efflux to apolipoprotein_A-I by increasing the cell surface presence of ATP-binding_cassette_transporter_A1 .
12649271	0	Ceramide	0,8	beta-site_amyloid_precursor_protein-cleaving_enzyme_1	20,73	Ceramide	beta-site amyloid precursor protein-cleaving enzyme 1	CHEBI:17761	23621	Chemical	Gene	stabilizes|nsubj|START_ENTITY stabilizes|xcomp|END_ENTITY	Ceramide stabilizes beta-site_amyloid_precursor_protein-cleaving_enzyme_1 and promotes amyloid beta-peptide biogenesis .
12562509	0	Ceramide	0,8	caspase_8	57,66	Ceramide	caspase 8	CHEBI:17761	64044(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|nmod|END_ENTITY	Ceramide increases mitochondrial free calcium levels via caspase_8 and Bid : role in initiation of cell death .
24758915	0	Ceramide	0,8	connective_tissue_growth_factor	18,49	Ceramide	connective tissue growth factor	CHEBI:17761	1490	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Ceramide inhibits connective_tissue_growth_factor expression by human retinal pigment epithelial cells .
11099485	0	Ceramide	0,8	cytosolic_phospholipase_A2	37,63	Ceramide	cytosolic phospholipase A2	CHEBI:17761	5321	Chemical	Gene	binds|nsubj|START_ENTITY binds|nmod|domain domain|nmod|END_ENTITY	Ceramide binds to the CaLB domain of cytosolic_phospholipase_A2 and facilitates its membrane docking and arachidonic_acid release .
7607324	0	Ceramide	0,8	insulin	39,46	Ceramide	insulin	CHEBI:17761	3630	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	Ceramide inhibits pancreatic beta-cell insulin production and mitogenesis and mimics the actions of interleukin-1_beta .
7629516	0	Ceramide	0,8	interleukin_6	17,30	Ceramide	interleukin 6	CHEBI:17761	3569	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Ceramide induces interleukin_6 gene expression in human fibroblasts .
9195956	1	Ceramide	65,73	nuclear_factor_kappaB	111,132	Ceramide	nuclear factor kappaB	CHEBI:17761	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	Ceramide inhibits phorbol_ester activation of nuclear_factor_kappaB .
16180087	0	Ceramide	0,8	p38	35,38	Ceramide	p38	CHEBI:17761	417553(Tax:9031)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|kinase kinase|amod|END_ENTITY	Ceramide activates a mitochondrial p38 mitogen-activated protein kinase : a potential mechanism for loss of mitochondrial transmembrane potential and apoptosis .
10493721	0	Ceramide	0,8	p75_neurotrophin_receptor	37,62	Ceramide	p75 neurotrophin receptor	CHEBI:17761	24596(Tax:10116)	Chemical	Gene	downstream|compound|START_ENTITY downstream|nmod|END_ENTITY	Ceramide signaling downstream of the p75_neurotrophin_receptor mediates the effects of nerve_growth_factor on outgrowth of cultured hippocampal neurons .
14615385	0	Ceramide	0,8	phospholipase_D	23,38	Ceramide	phospholipase D	CHEBI:17761	2822	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Ceramide inhibition of phospholipase_D and its relationship to RhoA and ARF1 translocation in GTP gamma S-stimulated polymorphonuclear leukocytes .
11551222	0	Ceramide	0,8	phospholipase_D1	33,49	Ceramide	phospholipase D1	CHEBI:17761	5337	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Ceramide inhibition of mammalian phospholipase_D1 and D2 activities is antagonized by phosphatidylinositol_4 ,5 - bisphosphate .
14563411	0	Ceramide	0,8	protein_kinase_C-alpha	34,56	Ceramide	protein kinase C-alpha	CHEBI:17761	5578	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|translocation translocation|nmod|END_ENTITY	Ceramide induces translocation of protein_kinase_C-alpha to the Golgi compartment of human_embryonic_kidney cells by interacting with the C2 domain .
16183668	0	Ceramide	0,8	surfactant_protein_B	19,39	Ceramide	surfactant protein B	CHEBI:17761	6439	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|amod|END_ENTITY	Ceramide decreases surfactant_protein_B gene expression via downregulation of TTF-1 DNA binding activity .
24422988	0	Ceramide	0,8	xIAP	17,21	Ceramide	xIAP	CHEBI:17761	331	Chemical	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Ceramide targets xIAP and cIAP1 to sensitize metastatic colon and breast_cancer cells to apoptosis induction to suppress tumor progression .
11057870	0	Cerivastatin	0,12	HMG-CoA_reductase	30,47	Cerivastatin	HMG-CoA reductase	MESH:C086276	3156	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Cerivastatin , an inhibitor of HMG-CoA_reductase , inhibits urokinase/urokinase-receptor expression and MMP-9 secretion by peripheral blood monocytes -- a possible protective mechanism against atherothrombosis .
12501010	0	Cerivastatin	0,12	HMG-CoA_reductase	16,33	Cerivastatin	HMG-CoA reductase	MESH:C086276	3156	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Cerivastatin , a HMG-CoA_reductase inhibitor , reduces plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- expression in endothelial cells by down-regulation of cellular signaling and the inhibition of PAI-1 promoter activity .
10694484	0	Cerivastatin	0,12	ICAM-1	51,57	Cerivastatin	ICAM-1	MESH:C086276	281839(Tax:9913)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Cerivastatin suppresses lipopolysaccharide-induced ICAM-1 expression through inhibition of Rho GTPase in BAEC .
16529752	0	Cerivastatin	0,12	ICAM-1	60,66	Cerivastatin	ICAM-1	MESH:C086276	3383	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|nmod|END_ENTITY	Cerivastatin reduces cytokine-induced surface expression of ICAM-1 via increased shedding in human endothelial cells .
12145176	0	Cerivastatin	0,12	insulin	22,29	Cerivastatin	insulin	MESH:C086276	3630	Chemical	Gene	improves|nsubj|START_ENTITY improves|dobj|sensitivity sensitivity|compound|END_ENTITY	Cerivastatin improves insulin sensitivity and insulin secretion in early-state obese_type_2_diabetes .
12501010	0	Cerivastatin	0,12	plasminogen_activator_inhibitor-1	53,86	Cerivastatin	plasminogen activator inhibitor-1	MESH:C086276	5054	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|amod|END_ENTITY	Cerivastatin , a HMG-CoA_reductase inhibitor , reduces plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- expression in endothelial cells by down-regulation of cellular signaling and the inhibition of PAI-1 promoter activity .
11005752	0	Cerulein	0,8	ICAM-1	21,27	Cerulein	ICAM-1	MESH:D002108	25464(Tax:10116)	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	Cerulein upregulates ICAM-1 in pancreatic acinar cells , which mediates neutrophil adhesion to these cells .
24046423	0	Cerulenin	0,9	heat_shock_protein-70	22,43	Cerulenin	heat shock protein-70	MESH:D002569	423504(Tax:9031)	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Cerulenin upregulates heat_shock_protein-70 gene expression in chicken muscle .
9537772	0	Cetirizine	0,10	ICAM-1	54,60	Cetirizine	ICAM-1	MESH:D017332	3383	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|compound|END_ENTITY	Cetirizine and hydrocortisone differentially regulate ICAM-1 expression and chemokine release in cultured human keratinocytes .
11895193	0	Cetirizine	0,10	interleukin-4	21,34	Cetirizine	interleukin-4	MESH:D017332	16189(Tax:10090)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|END_ENTITY	Cetirizine decreases interleukin-4 , interleukin-5 , and interferon-gamma gene expressions in nasal-associated lymphoid tissue of sensitized mice .
10594545	0	Cetirizine	0,10	interleukin-8	29,42	Cetirizine	interleukin-8	MESH:D017332	3576	Chemical	Gene	release|amod|START_ENTITY release|amod|END_ENTITY	Cetirizine counter-regulates interleukin-8 release from human epithelial cells -LRB- A549 -RRB- BACKGROUND : Cetirizine , a H1-receptor antagonist , exerts besides its well-known anti-allergic potential an array of anti-inflammatory activities .
14720269	0	Cetirizine	0,10	macrophage_migration_inhibitory_factor	68,106	Cetirizine	macrophage migration inhibitory factor	MESH:D017332	4282	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|nmod|END_ENTITY	Cetirizine , an H1-receptor antagonist , suppresses the expression of macrophage_migration_inhibitory_factor : its potential anti-inflammatory action .
8062939	0	Cetrorelix	74,84	GnRH	165,169	Cetrorelix	GnRH	MESH:C062876	2796	Chemical	Gene	postpones|appos|START_ENTITY injection|nmod|postpones injection|dep|evidence evidence|nmod|role role|nmod|END_ENTITY	A single injection of a gonadotropin-releasing_hormone -LRB- GnRH -RRB- antagonist -LRB- Cetrorelix -RRB- postpones the luteinizing hormone -LRB- LH -RRB- surge : further evidence for the role of GnRH during the LH surge .
8062939	0	Cetrorelix	74,84	GnRH	56,60	Cetrorelix	GnRH	MESH:C062876	2796	Chemical	Gene	postpones|appos|START_ENTITY postpones|appos|END_ENTITY	A single injection of a gonadotropin-releasing_hormone -LRB- GnRH -RRB- antagonist -LRB- Cetrorelix -RRB- postpones the luteinizing hormone -LRB- LH -RRB- surge : further evidence for the role of GnRH during the LH surge .
9806259	0	Cetrorelix	30,40	GnRH	13,17	Cetrorelix	GnRH	MESH:C062876	2796	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	The use of a GnRH antagonist -LRB- Cetrorelix -RRB- in a single dose protocol in IVF-embryo transfer : a dose finding study of 3 versus 2 mg .
19213514	0	Cetrorelix	25,35	GnRh	8,12	Cetrorelix	GnRh	MESH:C062876	2796	Chemical	Gene	Use|appos|START_ENTITY Use|nmod|antagonist antagonist|compound|END_ENTITY	-LSB- Use of GnRh antagonist -LRB- Cetrorelix -RRB- in controlled ovarian_hyperstimulation in women with polycystic_ovary_disease -RSB- .
15713828	0	Cetrorelix	43,53	Gonadotropin-releasing_hormone	0,30	Cetrorelix	Gonadotropin-releasing hormone	MESH:C062876	2796	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Gonadotropin-releasing_hormone antagonist -LRB- Cetrorelix -RRB- therapy fails to protect nonhuman primates -LRB- Macaca arctoides -RRB- from radiation-induced spermatogenic_failure .
11172036	0	Cetrorelix	57,67	LH-RH	130,135	Cetrorelix	LH-RH	MESH:C062876	25194(Tax:10116)	Chemical	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|nmod|receptors receptors|nmod|END_ENTITY	Luteinizing_hormone-releasing_hormone -LRB- LH-RH -RRB- antagonist Cetrorelix down-regulates the mRNA expression of pituitary receptors for LH-RH by counteracting the stimulatory effect of endogenous LH-RH .
11172036	0	Cetrorelix	57,67	LH-RH	190,195	Cetrorelix	LH-RH	MESH:C062876	25194(Tax:10116)	Chemical	Gene	down-regulates|nsubj|START_ENTITY down-regulates|advcl|counteracting counteracting|dobj|effect effect|nmod|END_ENTITY	Luteinizing_hormone-releasing_hormone -LRB- LH-RH -RRB- antagonist Cetrorelix down-regulates the mRNA expression of pituitary receptors for LH-RH by counteracting the stimulatory effect of endogenous LH-RH .
8637885	0	Cetrorelix	117,127	LH-RH	82,87	Cetrorelix	LH-RH	MESH:C062876	25194(Tax:10116)	Chemical	Gene	rats|nmod|START_ENTITY Down-regulation|nmod|rats Down-regulation|appos|END_ENTITY	Down-regulation of pituitary receptors for luteinizing_hormone-releasing_hormone -LRB- LH-RH -RRB- in rats by LH-RH antagonist Cetrorelix .
10605180	0	Cetrorelix	65,75	LHRH	48,52	Cetrorelix	LHRH	MESH:C062876	2796	Chemical	Gene	-RSB-|compound|START_ENTITY treatment|dep|-RSB- treatment|nmod|fibroids fibroids|nmod|antagonist antagonist|compound|END_ENTITY	-LSB- Medical treatment of uterine fibroids with the LHRH antagonist : Cetrorelix -RSB- .
15044692	0	Cetrorelix	68,78	LHRH	106,110	Cetrorelix	LHRH	MESH:C062876	25194(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of long-term treatment with low doses of the LHRH antagonist Cetrorelix on pituitary receptors for LHRH and gonadal_axis in male and female rats .
7921213	0	Cetrorelix	74,84	gonadotropin-releasing_hormone	32,62	Cetrorelix	gonadotropin-releasing hormone	MESH:C062876	2796	Chemical	Gene	START_ENTITY|nsubj|administration administration|nmod|antagonist antagonist|amod|END_ENTITY	Seven-day administration of the gonadotropin-releasing_hormone antagonist Cetrorelix in normal cycling women .
8062939	0	Cetrorelix	74,84	gonadotropin-releasing_hormone	24,54	Cetrorelix	gonadotropin-releasing hormone	MESH:C062876	2796	Chemical	Gene	postpones|appos|START_ENTITY postpones|amod|END_ENTITY	A single injection of a gonadotropin-releasing_hormone -LRB- GnRH -RRB- antagonist -LRB- Cetrorelix -RRB- postpones the luteinizing hormone -LRB- LH -RRB- surge : further evidence for the role of GnRH during the LH surge .
9130900	0	Cetrorelix	75,85	gonadotropin-releasing_hormone	33,63	Cetrorelix	gonadotropin-releasing hormone	MESH:C062876	2796	Chemical	Gene	START_ENTITY|nsubj|Comparison Comparison|nmod|doses doses|nmod|antagonist antagonist|amod|END_ENTITY	Comparison of different doses of gonadotropin-releasing_hormone antagonist Cetrorelix during controlled ovarian_hyperstimulation .
8637885	0	Cetrorelix	117,127	luteinizing_hormone-releasing_hormone	43,80	Cetrorelix	luteinizing hormone-releasing hormone	MESH:C062876	25194(Tax:10116)	Chemical	Gene	rats|nmod|START_ENTITY Down-regulation|nmod|rats Down-regulation|nmod|receptors receptors|nmod|END_ENTITY	Down-regulation of pituitary receptors for luteinizing_hormone-releasing_hormone -LRB- LH-RH -RRB- in rats by LH-RH antagonist Cetrorelix .
12513885	0	Cetrotide	126,135	gonadotrophin-releasing_hormone	82,113	Cetrotide	gonadotrophin-releasing hormone	MESH:C062876	2796	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Preoperative reduction of uterine fibroids in only 16 days by administration of a gonadotrophin-releasing_hormone antagonist -LRB- Cetrotide -RRB- .
25714087	0	Chabamide	0,9	P-glycoprotein	92,106	Chabamide	P-glycoprotein	MESH:C469492	5243	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|pathway pathway|nmod|END_ENTITY	Chabamide induces cell cycle arrest and apoptosis by the Akt/MAPK pathway and inhibition of P-glycoprotein in K562/ADR cells .
24699775	0	Chabazite	0,9	CO2	30,33	Chabazite	CO2	MESH:C554923	717	Chemical	Gene	START_ENTITY|nmod|capture capture|compound|END_ENTITY	Chabazite and zeolite 13X for CO2 capture under high pressure and moderate temperature conditions .
26748310	0	Chaetocin	0,9	ERK	99,102	Chaetocin	ERK	MESH:C002511	26413(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|activation activation|nmod|END_ENTITY	Chaetocin inhibits IBMX-induced melanogenesis in B16F10 mouse melanoma cells through activation of ERK .
26575580	0	Chalcone	20,28	Tyrosinase	53,63	Chalcone	Tyrosinase	MESH:D002599	22173(Tax:10090)	Chemical	Gene	Oximes|compound|START_ENTITY Evaluation|nmod|Oximes Evaluation|nmod|Formation Formation|compound|END_ENTITY	Evaluation of Novel Chalcone Oximes as Inhibitors of Tyrosinase and Melanin Formation in B16 Cells .
15231412	0	Chalcones	0,9	tyrosinase	20,30	Chalcones	tyrosinase	MESH:D047188	7299	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Chalcones as potent tyrosinase inhibitors : the effect of hydroxyl positions and numbers .
15598564	0	Chalcones	0,9	tyrosinase	20,30	Chalcones	tyrosinase	MESH:D047188	7299	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Chalcones as potent tyrosinase inhibitors : the importance of a 2,4-substituted _ resorcinol moiety .
18359842	0	Chaperone	0,9	ERD10	22,27	Chaperone	ERD10	null	838633(Tax:3702)	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Chaperone activity of ERD10 and ERD14 , two disordered stress-related plant proteins .
25037721	0	Chaperone	8,17	GCase	2,7	Chaperone	GCase	null	14466(Tax:10090)	Chemical	Gene	Function|compound|START_ENTITY Function|compound|END_ENTITY	A GCase Chaperone Improves Motor Function in a Mouse Model of Synucleinopathy .
26381739	0	Chaperone	33,42	Hsp27	0,5	Chaperone	Hsp27	null	3315	Chemical	Gene	Acts|nmod|START_ENTITY Acts|nsubj|END_ENTITY	Hsp27 Acts as a Master Molecular Chaperone and Plays an Essential Role in Hepatocellular_Carcinoma Progression .
26401872	0	Chaperone	162,171	Hsp70-2	154,161	Chaperone	Hsp70-2	null	294254(Tax:10116)	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Simultaneous Administration of Dexamethasone and Vitamin_E Reversed Experimental Varicocele-induced Impact in testicular tissue in Rats ; Correlation with Hsp70-2 Chaperone Expression .
24492254	0	Chaperone	0,9	LON_protease_2	36,50	Chaperone	LON protease 2	null	834750(Tax:3702)	Chemical	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	Chaperone and protease functions of LON_protease_2 modulate the peroxisomal transition and degradation with autophagy .
21403913	0	Chaperone	29,38	Nucleolin	51,60	Chaperone	Nucleolin	null	4691	Chemical	Gene	Activity|compound|START_ENTITY Activity|nmod|END_ENTITY	In vivo Study of the Histone Chaperone Activity of Nucleolin by FRAP .
26009280	0	Chaperone	4,13	Sip1	69,73	Chaperone	Sip1	null	176471(Tax:6239)	Chemical	Gene	Activity|amod|START_ENTITY Activity|nmod|END_ENTITY	The Chaperone Activity of the Developmental Small Heat Shock Protein Sip1 Is Regulated by pH-Dependent Conformational Changes .
26580605	0	Chaperone	15,24	Thioredoxin	52,63	Chaperone	Thioredoxin	null	7295	Chemical	Gene	Activity|compound|START_ENTITY Activity|nmod|END_ENTITY	Enhancement of Chaperone Activity of Plant-Specific Thioredoxin through y-Ray Mediated Conformational Change .
7768954	0	Chaperone	0,9	bile_salt-dependent_lipase	91,117	Chaperone	bile salt-dependent lipase	null	1056	Chemical	Gene	function|amod|START_ENTITY function|nmod|END_ENTITY	Chaperone function of a Grp_94-related protein for folding and transport of the pancreatic bile_salt-dependent_lipase .
7907329	0	Chaperone	0,9	calnexin	22,30	Chaperone	calnexin	null	403908(Tax:9615)	Chemical	Gene	function|amod|START_ENTITY function|nmod|END_ENTITY	Chaperone function of calnexin for the folding intermediate of gp80 , the major secretory protein in MDCK cells .
9661269	0	Chaperone	0,9	calreticulin	24,36	Chaperone	calreticulin	null	811	Chemical	Gene	properties|amod|START_ENTITY properties|nmod|END_ENTITY	Chaperone properties of calreticulin .
11795871	0	Chaperone	0,9	meprin_A	48,56	Chaperone	meprin A	null	17287(Tax:10090)	Chemical	Gene	interactions|amod|START_ENTITY interactions|nmod|END_ENTITY	Chaperone interactions of the metalloproteinase meprin_A in the secretory or proteasomal-degradative pathway .
23660595	0	Chaperone	0,9	pdia3	24,29	Chaperone	pdia3	null	14827(Tax:10090)	Chemical	Gene	properties|amod|START_ENTITY properties|nmod|END_ENTITY	Chaperone properties of pdia3 participate in rapid membrane actions of 1a,25-dihydroxyvitamin _ d3 .
12549977	0	Chaperone	0,9	thioredoxin	41,52	Chaperone	thioredoxin	null	280950(Tax:9913)	Chemical	Gene	properties|amod|START_ENTITY properties|nmod|END_ENTITY	Chaperone properties of Escherichia_coli thioredoxin and thioredoxin reductase .
26170946	0	Chebulagic_acid	0,15	TNF-a	55,60	Chebulagic acid	TNF-a	MESH:C076178	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Chebulagic_acid inhibits the LPS-induced expression of TNF-a and IL-1b in endothelial cells by suppressing MAPK activation .
974036	0	Chelate	0,7	transferrin	39,50	Chelate	transferrin	null	7018	Chemical	Gene	mediated|nsubj|START_ENTITY mediated|nmod|END_ENTITY	Chelate mediated transfer of iron from transferrin to desferrioxamine .
12893631	0	Chelerythrine	0,13	Mrp2	46,50	Chelerythrine	Mrp2	MESH:C016299	25303(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|END_ENTITY	Chelerythrine stimulates GSH transport by rat Mrp2 -LRB- Abcc2 -RRB- expressed in canine kidney cells .
10847634	0	Chelerythrine_chloride	0,22	caspase-3	97,106	Chelerythrine chloride	caspase-3	MESH:C016299	836	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Chelerythrine_chloride induces rapid polymorphonuclear leukocyte apoptosis through activation of caspase-3 .
22751440	0	Chenodeoxycholic_acid	0,21	CREB	47,51	Chenodeoxycholic acid	CREB	MESH:D002635	1385	Chemical	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	Chenodeoxycholic_acid through a TGR5-dependent CREB signaling activation enhances cyclin_D1 expression and promotes human endometrial_cancer_cell_proliferation .
21165560	0	Chetomin	0,8	XIAP	32,36	Chetomin	XIAP	MESH:C001598	331	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|degradation degradation|nmod|END_ENTITY	Chetomin induces degradation of XIAP and enhances TRAIL sensitivity in urogenital_cancer cells .
26929249	0	Chikusetsusaponin	0,17	IL-6R	57,62	Chikusetsusaponin	IL-6R	null	3570	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Chikusetsusaponin a butyl_ester -LRB- CS - ___ a-Be -RRB- , a novel IL-6R antagonist , inhibits IL-6 / STAT3 signaling pathway and induces cancer cell apoptosis .
26929249	0	Chikusetsusaponin	0,17	STAT3	89,94	Chikusetsusaponin	STAT3	null	6774	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Chikusetsusaponin a butyl_ester -LRB- CS - ___ a-Be -RRB- , a novel IL-6R antagonist , inhibits IL-6 / STAT3 signaling pathway and induces cancer cell apoptosis .
23284959	0	Chimaerin	0,9	Rac1	21,25	Chimaerin	Rac1	null	5879	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|activation activation|amod|END_ENTITY	Chimaerin suppresses Rac1 activation at the apical membrane to maintain the cyst structure .
21351488	0	Chinfloxacin_hydrochloride	1,27	HERG	37,41	Chinfloxacin hydrochloride	HERG	null	3757	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	-LSB- Chinfloxacin_hydrochloride inhibits HERG potassium channel at open state -RSB- .
19305158	0	Chir-124	22,30	CHK1	44,48	Chir-124	CHK1	MESH:C518919	1111	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Radiosensitization by Chir-124 , a selective CHK1 inhibitor : effects of p53 and cell cycle checkpoints .
22654663	0	Chitohexaose	0,12	TLR4	64,68	Chitohexaose	TLR4	MESH:C050523	21898(Tax:10090)	Chemical	Gene	activates|nsubj|START_ENTITY activates|nmod|END_ENTITY	Chitohexaose activates macrophages by alternate pathway through TLR4 and blocks_endotoxemia .
10473103	0	Chlorambucil	0,12	HsRad51	26,33	Chlorambucil	HsRad51	MESH:D002699	5888	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Chlorambucil induction of HsRad51 in B-cell_chronic_lymphocytic_leukemia .
14576103	0	Chloramphenicol	0,15	CYP2C19	66,73	Chloramphenicol	CYP2C19	MESH:D002701	1557	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Chloramphenicol is a potent inhibitor of cytochrome P450 isoforms CYP2C19 and CYP3A4 in human liver microsomes .
23167761	0	Chloramphenicol	0,15	IDUA	25,29	Chloramphenicol	IDUA	MESH:D002701	3425	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|compound|END_ENTITY	Chloramphenicol enhances IDUA activity on fibroblasts from mucopolysaccharidosis_I patients .
16668525	0	Chlorate	10,18	Nitrate_Reductase	32,49	Chlorate	Nitrate Reductase	CHEBI:49709	844112(Tax:3702)	Chemical	Gene	Treatment|compound|START_ENTITY Treatment|nmod|END_ENTITY	Effect of Chlorate Treatment on Nitrate_Reductase and Nitrite_Reductase Gene Expression in Arabidopsis_thaliana .
1692334	0	Chlordecone	0,11	calmodulin	27,37	Chlordecone	calmodulin	MESH:D007631	808	Chemical	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	Chlordecone interaction of calmodulin binding with phosphodiesterase .
12803421	0	Chloride	0,8	ATPase	9,15	Chloride	ATPase	CHEBI:17996	1769	Chemical	Gene	pumps|compound|START_ENTITY pumps|compound|END_ENTITY	Chloride ATPase pumps in nature : do they exist ?
26661654	0	Chloride	69,77	Angiotensin_II	8,22	Chloride	Angiotensin II	CHEBI:17996	24179(Tax:10116)	Chemical	Gene	Transport|compound|START_ENTITY Stimulates|dobj|Transport Stimulates|nsubj|END_ENTITY	Luminal Angiotensin_II Stimulates Rat Medullary Thick Ascending Limb Chloride Transport in the in the Presence of Basolateral Norepinephrine .
26904077	0	Chloride	26,34	AtCLCe	43,49	Chloride	AtCLCe	CHEBI:17996	829696(Tax:3702)	Chemical	Gene	Functions|compound|START_ENTITY Functions|compound|END_ENTITY	The Arabidopsis Thylakoid Chloride Channel AtCLCe Functions in Chloride Homeostasis and Regulation of Photosynthetic Electron Transport .
11179391	10	Chloride	984,992	CFTR	1010,1014	Chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	currents|amod|START_ENTITY currents|nmod|channels channels|amod|END_ENTITY	Chloride currents through CFTR channels were blocked by low concentrations -LRB- 10 mM -RRB- of SCN - , _ I - _ and_ClO4 - , implying relatively tight binding of these anions within the pore .
11390879	0	Chloride	5,13	CFTR	0,4	Chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	Channels|compound|START_ENTITY Channels|compound|END_ENTITY	CFTR Chloride Channels : Binding Partners and Regulatory Networks .
11390899	0	Chloride	61,69	CFTR	56,60	Chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	Channel|compound|START_ENTITY Channel|compound|END_ENTITY	Stimulatory and Inhibitory Functions of the R Domain on CFTR Chloride Channel .
15650130	0	Chloride	0,8	CFTR	24,28	Chloride	CFTR	CHEBI:17996	12638(Tax:10090)	Chemical	Gene	conductance|amod|START_ENTITY conductance|nmod|HCO3 HCO3|compound|END_ENTITY	Chloride conductance of CFTR facilitates basal Cl - / HCO3 - exchange in the villous epithelium of intact murine duodenum .
17339840	0	Chloride	0,8	CFTR	144,148	Chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	START_ENTITY|xcomp|transporting transporting|dobj|capability capability|nmod|epithelia epithelia|nmod|knockdown knockdown|nmod|regulator regulator|appos|END_ENTITY	Chloride transporting capability of Calu-3 epithelia following persistent knockdown of the cystic_fibrosis transmembrane conductance regulator , CFTR .
26174774	0	Chloride	61,69	CFTR	56,60	Chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	Channel|compound|START_ENTITY Channel|compound|END_ENTITY	Benzopyrimido-pyrrolo-oxazine-dione -LRB- R -RRB- - BPO-27 Inhibits CFTR Chloride Channel Gating by Competition with ATP .
9482946	0	Chloride	0,8	CFTR	63,67	Chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY conductance|nsubj|channel conductance|dobj|domains domains|nmod|END_ENTITY	Chloride channel and chloride conductance regulator domains of CFTR , the cystic_fibrosis transmembrane conductance regulator .
26021757	0	Chloride	92,100	CLC-1	86,91	Chloride	CLC-1	CHEBI:17996	1180	Chemical	Gene	Channels|compound|START_ENTITY Channels|compound|END_ENTITY	The Cullin_4A / B-DDB1-Cereblon E3_Ubiquitin_Ligase Complex Mediates the Degradation of CLC-1 Chloride Channels .
26021757	0	Chloride	92,100	CLC-1	86,91	Chloride	CLC-1	CHEBI:17996	1180	Chemical	Gene	Channels|compound|START_ENTITY Channels|compound|END_ENTITY	The Cullin_4A / B-DDB1-Cereblon E3_Ubiquitin_Ligase Complex Mediates the Degradation of CLC-1 Chloride Channels .
17135300	0	Chloride	0,8	CLCN1	103,108	Chloride	CLCN1	CHEBI:17996	12723(Tax:10090)	Chemical	Gene	START_ENTITY|advcl|resulting resulting|nmod|loss loss|nmod|regulation regulation|nmod|END_ENTITY	Chloride channelopathy in myotonic_dystrophy resulting from loss of posttranscriptional regulation for CLCN1 .
25546839	0	Chloride	0,8	CLIC1	78,83	Chloride	CLIC1	CHEBI:17996	1192	Chemical	Gene	channels|amod|START_ENTITY channels|dep|Focus Focus|nmod|proteins proteins|appos|END_ENTITY	Chloride channels in cancer : Focus on chloride_intracellular_channel_1_and_4 -LRB- CLIC1 AND CLIC4 -RRB- proteins in tumor development and as novel therapeutic targets .
19551886	0	Chloride	0,8	ClC	66,69	Chloride	ClC	CHEBI:17996	1178	Chemical	Gene	START_ENTITY|nmod|coordination coordination|nmod|pore pore|nmod|protein protein|compound|END_ENTITY	Chloride ion conduction without water coordination in the pore of ClC protein .
24378849	0	Chloride	0,8	ClC-2	28,33	Chloride	ClC-2	CHEBI:17996	1181	Chemical	Gene	channelopathies|amod|START_ENTITY channelopathies|nmod|END_ENTITY	Chloride channelopathies of ClC-2 .
20506205	0	Chloride	0,8	ClC-3	17,22	Chloride	ClC-3	CHEBI:17996	12725(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|promotion promotion|compound|END_ENTITY	Chloride channel ClC-3 promotion of osteogenic differentiation through Runx2 .
26769712	0	Chloride	105,113	ClC-3	19,24	Chloride	ClC-3	CHEBI:17996	1182	Chemical	Gene	Currents|compound|START_ENTITY Migration|nmod|Currents Reduces|dobj|Migration Reduces|nsubj|Down-Regulation Down-Regulation|nmod|Expression Expression|compound|END_ENTITY	Down-Regulation of ClC-3 Expression Reduces Epidermal Stem Cell Migration by Inhibiting Volume-Activated Chloride Currents .
14584882	0	Chloride	0,8	ClCN7	17,22	Chloride	ClCN7	CHEBI:17996	1186	Chemical	Gene	mutations|amod|START_ENTITY mutations|compound|END_ENTITY	Chloride channel ClCN7 mutations are responsible for severe recessive , dominant , and intermediate osteopetrosis .
25143385	0	Chloride	129,137	Cystic_Fibrosis_Transmembrane_Conductance_Regulator	77,128	Chloride	Cystic Fibrosis Transmembrane Conductance Regulator	CHEBI:17996	1080	Chemical	Gene	Channel|compound|START_ENTITY Channel|compound|END_ENTITY	Metal Bridges Illuminate Transmembrane Domain Movements during Gating of the Cystic_Fibrosis_Transmembrane_Conductance_Regulator Chloride Channel .
25944907	0	Chloride	111,119	Cystic_Fibrosis_Transmembrane_Conductance_Regulator	59,110	Chloride	Cystic Fibrosis Transmembrane Conductance Regulator	CHEBI:17996	1080	Chemical	Gene	Pore|compound|START_ENTITY Pore|compound|END_ENTITY	Functional Architecture of the Cytoplasmic Entrance to the Cystic_Fibrosis_Transmembrane_Conductance_Regulator Chloride Channel Pore .
25944907	0	Chloride	111,119	Cystic_Fibrosis_Transmembrane_Conductance_Regulator	59,110	Chloride	Cystic Fibrosis Transmembrane Conductance Regulator	CHEBI:17996	1080	Chemical	Gene	Pore|compound|START_ENTITY Pore|compound|END_ENTITY	Functional Architecture of the Cytoplasmic Entrance to the Cystic_Fibrosis_Transmembrane_Conductance_Regulator Chloride Channel Pore .
26858607	0	Chloride	44,52	KCC2	5,9	Chloride	KCC2	CHEBI:17996	57468	Chemical	Gene	Dysregulation|compound|START_ENTITY Dysregulation|compound|END_ENTITY	Mild KCC2 Hypofunction Causes Inconspicuous Chloride Dysregulation that Degrades Neural Coding .
26924708	0	Chloride	104,112	KCC2	99,103	Chloride	KCC2	CHEBI:17996	171373(Tax:10116)	Chemical	Gene	Transporters|compound|START_ENTITY Transporters|compound|END_ENTITY	Early IGF-1 Primes Visual Cortex Maturation And Accelerates Developmental Switch Between NKCC1 and KCC2 Chloride Transporters in Enriched Animals .
25585037	0	Chloride	0,8	NKCC1	23,28	Chloride	NKCC1	CHEBI:17996	6558	Chemical	Gene	bumetanide|amod|START_ENTITY bumetanide|nummod|END_ENTITY	Chloride cotransporter NKCC1 inhibitor bumetanide protects against white_matter_injury in a rodent model of periventricular_leukomalacia .
26960329	0	Chloride	0,8	NKCC1	24,29	Chloride	NKCC1	CHEBI:17996	83629(Tax:10116)	Chemical	Gene	START_ENTITY|xcomp|Neurogenesis Neurogenesis|compound|END_ENTITY	Chloride Co-transporter NKCC1 Inhibitor Bumetanide Enhances Neurogenesis and Behavioral Recovery in Rats After Experimental Stroke .
26711895	0	Chloride	99,107	NPPB	91,95	Chloride	NPPB	CHEBI:17996	4879	Chemical	Gene	Blocker|compound|START_ENTITY END_ENTITY|appos|Blocker	Double Blockade of Glioma Cell Proliferation and Migration by Temozolomide Conjugated with NPPB , a Chloride Channel Blocker .
26181339	0	Chloride	45,53	TMEM16A	19,26	Chloride	TMEM16A	CHEBI:17996	55107	Chemical	Gene	Tone|compound|START_ENTITY Tone|compound|END_ENTITY	Antagonists of the TMEM16A Calcium-activated Chloride Channel Modulate Airway Smooth Muscle Tone and Intracellular Calcium .
26181339	0	Chloride	45,53	TMEM16A	19,26	Chloride	TMEM16A	CHEBI:17996	55107	Chemical	Gene	Tone|compound|START_ENTITY Tone|compound|END_ENTITY	Antagonists of the TMEM16A Calcium-activated Chloride Channel Modulate Airway Smooth Muscle Tone and Intracellular Calcium .
15506212	0	Chloride	0,8	TNT	19,22	Chloride	TNT	CHEBI:17996	162083	Chemical	Gene	effect|amod|START_ENTITY effect|nmod|END_ENTITY	Chloride effect on TNT degradation by zerovalent iron or zinc during water treatment .
10555568	0	Chloride	0,8	angiotensin_II	73,87	Chloride	angiotensin II	CHEBI:17996	24179(Tax:10116)	Chemical	Gene	blockers|amod|START_ENTITY attenuate|nsubj|blockers attenuate|nmod|END_ENTITY	Chloride channel blockers attenuate the inhibition of renin secretion by angiotensin_II .
14679313	0	Chloride	0,8	angiotensin_II	51,65	Chloride	angiotensin II	CHEBI:17996	24179(Tax:10116)	Chemical	Gene	blockade|amod|START_ENTITY attenuates|nsubj|blockade attenuates|dobj|effect effect|nmod|END_ENTITY	Chloride channel blockade attenuates the effect of angiotensin_II on tubuloglomerular feedback in WKY but not spontaneously hypertensive rats .
10555568	0	Chloride	0,8	renin	54,59	Chloride	renin	CHEBI:17996	24715(Tax:10116)	Chemical	Gene	blockers|amod|START_ENTITY attenuate|nsubj|blockers attenuate|dobj|inhibition inhibition|nmod|secretion secretion|compound|END_ENTITY	Chloride channel blockers attenuate the inhibition of renin secretion by angiotensin_II .
9328319	0	Chlormethiazole	0,15	cytochrome_P450_2E1	30,49	Chlormethiazole	cytochrome P450 2E1	MESH:D002719	1571	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Chlormethiazole inhibition of cytochrome_P450_2E1 as assessed by chlorzoxazone hydroxylation in humans .
9416771	0	Chloroethylclonidine	0,20	alpha1A-adrenoceptor	34,54	Chloroethylclonidine	alpha1A-adrenoceptor	MESH:C051731	29412(Tax:10116)	Chemical	Gene	agonist|nsubj|START_ENTITY agonist|amod|END_ENTITY	Chloroethylclonidine is a partial alpha1A-adrenoceptor agonist in cells expressing recombinant alpha1-adrenoceptor subtypes .
25953616	0	Chloroform	89,99	TRPV1	24,29	Chloroform	TRPV1	MESH:D002725	7442	Chemical	Gene	Required|nmod|START_ENTITY Required|nsubjpass|Domain Domain|nmod|END_ENTITY	The Pore Loop Domain of TRPV1 is Required for its Activation by the Volatile Anesthetics Chloroform and Isoflurane .
3418748	0	Chloroform	0,10	ornithine_decarboxylase_antizyme	24,56	Chloroform	ornithine decarboxylase antizyme	MESH:D002725	25502(Tax:10116)	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Chloroform induction of ornithine_decarboxylase_antizyme -LRB- ODC-AZ -RRB- in male rat liver .
15226183	0	Chlorogenic_acid	0,16	Bcr-Abl	26,33	Chlorogenic acid	Bcr-Abl	MESH:D002726	25	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|kinase kinase|amod|END_ENTITY	Chlorogenic_acid inhibits Bcr-Abl tyrosine kinase and triggers p38_mitogen-activated_protein_kinase-dependent apoptosis in chronic myelogenous leukemic cells .
19393773	0	Chlorogenic_acid	0,16	cyclooxygenase-2	53,69	Chlorogenic acid	cyclooxygenase-2	MESH:D002726	19225(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Chlorogenic_acid inhibits lipopolysaccharide-induced cyclooxygenase-2 expression in RAW264 .7 cells through suppressing NF-kappaB and JNK/AP -1 activation .
23168580	0	Chlorogenic_acid	0,16	high_mobility_group_box_1	28,53	Chlorogenic acid	high mobility group box 1	MESH:D002726	15289(Tax:10090)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|END_ENTITY	Chlorogenic_acid attenuates high_mobility_group_box_1 -LRB- HMGB1 -RRB- and enhances host defense mechanisms in murine sepsis .
19248222	0	Chlorogenic_acid	0,16	paraoxonase_1	26,39	Chlorogenic acid	paraoxonase 1	MESH:D002726	5444	Chemical	Gene	protects|nsubj|START_ENTITY protects|dobj|activity activity|amod|END_ENTITY	Chlorogenic_acid protects paraoxonase_1 activity in high density lipoprotein from inactivation caused by physiological concentrations of hypochlorite .
16275627	0	Chlorophyllin	0,13	IFN-gamma	25,34	Chlorophyllin	IFN-gamma	MESH:C007020	15978(Tax:10090)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|amod|END_ENTITY	Chlorophyllin attenuates IFN-gamma expression in lipopolysaccharide-stimulated murine splenic mononuclear cells via suppressing IL-12 production .
23091617	0	Chloroquine	0,11	Akt	32,35	Chloroquine	Akt	MESH:D002738	207	Chemical	Gene	START_ENTITY|parataxis|promote promote|nsubj|combinations combinations|compound|END_ENTITY	Chloroquine or chloroquine-PI3K / Akt pathway inhibitor combinations strongly promote y-irradiation-induced cell death in primary stem-like glioma cells .
23702482	0	Chloroquine	0,11	Akt	98,101	Chloroquine	Akt	MESH:D002738	207	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|activation activation|nmod|END_ENTITY	Chloroquine stimulates glucose uptake and glycogen synthase in muscle cells through activation of Akt .
16157687	0	Chloroquine	0,11	CD8	27,30	Chloroquine	CD8	MESH:D002738	925	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|responses responses|compound|END_ENTITY	Chloroquine enhances human CD8 + T cell responses against soluble antigens in vivo .
19210393	0	Chloroquine	0,11	Corticotrophin-Releasing_Factor	65,96	Chloroquine	Corticotrophin-Releasing Factor	MESH:D002738	81648(Tax:10116)	Chemical	Gene	Response|compound|START_ENTITY Response|nmod|END_ENTITY	Chloroquine Decreases Adrenocorticotrophin-Secretory Response to Corticotrophin-Releasing_Factor but not to Vasopressin in Rat Pituitary Cells : Further Evidence for Differentially Responsive Subpopulations .
23707973	0	Chloroquine	0,11	HMGB1	21,26	Chloroquine	HMGB1	MESH:D002738	15289(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|signaling signaling|nsubj|END_ENTITY	Chloroquine inhibits HMGB1 inflammatory signaling and protects mice from lethal sepsis .
16418198	0	Chloroquine	0,11	TNF-alpha	35,44	Chloroquine	TNF-alpha	MESH:D002738	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|nmod|END_ENTITY	Chloroquine inhibits production of TNF-alpha , IL-1beta and IL-6 from lipopolysaccharide-stimulated human monocytes/macrophages by different modes .
20017940	0	Chloroquine	0,11	arylsulphatase_B	20,36	Chloroquine	arylsulphatase B	MESH:D002738	411	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|activity activity|amod|END_ENTITY	Chloroquine reduces arylsulphatase_B activity and increases chondroitin-4-sulphate : implications for mechanisms of action and resistance .
10563518	0	Chloroquine	0,11	inducible_nitric_oxide_synthase	21,52	Chloroquine	inducible nitric oxide synthase	MESH:D002738	18126(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Chloroquine inhibits inducible_nitric_oxide_synthase expression in murine peritoneal macrophages .
1343942	0	Chloroquine	0,11	insulin	25,32	Chloroquine	insulin	MESH:D002738	3630	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Chloroquine inhibits the insulin binding and the imprinting of nuclear envelope in Tetrahymena .
7487933	0	Chloroquine	0,11	insulin	36,43	Chloroquine	insulin	MESH:D002738	3630	Chemical	Gene	augments|nsubj|START_ENTITY augments|dobj|the the|nmod|END_ENTITY	Chloroquine augments the binding of insulin to its receptor .
9002011	0	Chloroquine	0,11	tumor_necrosis_factor-alpha	50,77	Chloroquine	tumor necrosis factor-alpha	MESH:D002738	7124	Chemical	Gene	affect|nsubj|START_ENTITY affect|dobj|END_ENTITY	Chloroquine and hydroxychloroquine equally affect tumor_necrosis_factor-alpha , interleukin_6 , and interferon-gamma production by peripheral blood mononuclear cells .
11849318	0	Chloroquine	0,11	tumour_necrosis_factor	49,71	Chloroquine	tumour necrosis factor	MESH:D002738	7124	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|nmod|receptors receptors|compound|END_ENTITY	Chloroquine decreases cell-surface expression of tumour_necrosis_factor receptors in human histiocytic U-937 cells .
23457060	0	Chlorothiazide	0,14	OAT1	64,68	Chlorothiazide	OAT1	MESH:D002740	9356	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Chlorothiazide is a substrate for the human uptake transporters OAT1 and OAT3 .
15501047	0	Chlorothiophenecarboxamides	0,27	factor_Xa	80,89	Chlorothiophenecarboxamides	factor Xa	null	2159	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Chlorothiophenecarboxamides as P1 surrogates of inhibitors of blood_coagulation factor_Xa .
3942557	0	Chlorpromazine	0,14	ACAT	33,37	Chlorpromazine	ACAT	MESH:D002746	100009537(Tax:9986)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Chlorpromazine inhibits arterial ACAT and reduces arterial cholesterol and cholesteryl_ester accumulation in cholesterol-fed rabbits .
7927490	0	Chlorpromazine	0,14	TNF	58,61	Chlorpromazine	TNF	MESH:D002746	21926(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	Chlorpromazine specifically inhibits peripheral and brain TNF production , and up-regulates IL-10 production , in mice .
474035	0	Chlorpromazine	0,14	growth_hormone	33,47	Chlorpromazine	growth hormone	MESH:D002746	81668(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|compound|END_ENTITY	Chlorpromazine inhibits episodic growth_hormone secretion in the rat .
6110459	0	Chlorpromazine	0,14	prolactin	68,77	Chlorpromazine	prolactin	MESH:D002746	24683(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY END_ENTITY|nsubj|release	Chlorpromazine , haloperidol , metoclopramide and domperidone release prolactin through dopamine antagonism at low concentrations but paradoxically inhibit prolactin release at high concentrations .
9671376	0	Chlorpromazine	0,14	tumor_necrosis_factor-alpha	30,57	Chlorpromazine	tumor necrosis factor-alpha	MESH:D002746	21926(Tax:10090)	Chemical	Gene	down-regulates|amod|START_ENTITY END_ENTITY|nsubj|down-regulates	Chlorpromazine down-regulates tumor_necrosis_factor-alpha and attenuates experimental multiple_organ_dysfunction_syndrome in mice .
17365099	0	Chlorpyrifos	0,12	NR2A	72,76	Chlorpyrifos	NR2A	MESH:D004390	24409(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|nmod|END_ENTITY	Chlorpyrifos increases the levels of hippocampal NMDA receptor subunits NR2A and NR2B in juvenile and adult rats .
18076960	0	Chlorpyrifos	0,12	acetylcholinesterase	105,125	Chlorpyrifos	acetylcholinesterase	MESH:D004390	43	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|advcl|interfering interfering|nmod|activity activity|nmod|END_ENTITY	Chlorpyrifos and chlorpyrifos-oxon inhibit axonal growth by interfering with the morphogenic activity of acetylcholinesterase .
26680654	0	Chlorzoxazone	52,65	CYP2E1	33,39	Chlorzoxazone	CYP2E1	MESH:D002753	1571	Chemical	Gene	Activity|nmod|START_ENTITY Activity|compound|END_ENTITY	Resveratrol Pretreatment Affects CYP2E1 Activity of Chlorzoxazone in Healthy Human Volunteers .
8849486	0	Chlorzoxazone	0,13	CYP2E1	50,56	Chlorzoxazone	CYP2E1	MESH:D002753	1571	Chemical	Gene	START_ENTITY|nmod|probe probe|nmod|activity activity|compound|END_ENTITY	Chlorzoxazone as a single sample probe of hepatic CYP2E1 activity in humans .
22889840	0	Cholecalciferol	0,15	parathyroid_hormone	105,124	Cholecalciferol	parathyroid hormone	MESH:D002762	5741	Chemical	Gene	supplementation_in_chronic_kidney_disease|amod|START_ENTITY supplementation_in_chronic_kidney_disease|dep|restoration restoration|nmod|END_ENTITY	Cholecalciferol supplementation_in_chronic_kidney_disease : restoration of vitamin_D status and impact on parathyroid_hormone .
1612109	0	Cholecystokinin	0,15	CCK	82,85	Cholecystokinin	CCK	MESH:D002766	885	Chemical	Gene	contracts|compound|START_ENTITY isolated|nsubj|contracts isolated|dobj|sphincters sphincters|dep|study study|nmod|antagonists antagonists|compound|END_ENTITY	Cholecystokinin contracts isolated human and monkey iris sphincters ; a study with CCK receptor antagonists .
18058604	0	Cholecystokinin	0,15	CCK	17,20	Cholecystokinin	CCK	MESH:D002766	885	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Cholecystokinin -LRB- CCK -RRB- receptor and CCK gene expression in human pituitary_adenomas and in vitro effects of CCK peptides on GH and gonadotrophin secretion .
7800848	0	Cholecystokinin	0,15	CCK	119,122	Cholecystokinin	CCK	MESH:D002766	25298(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|interacting interacting|nmod|sites sites|compound|END_ENTITY	Cholecystokinin inhibits gastric emptying and contracts the pyloric sphincter in rats by interacting with low affinity CCK receptor sites .
8183538	0	Cholecystokinin	0,15	CCK	17,20	Cholecystokinin	CCK	MESH:D002766	25298(Tax:10116)	Chemical	Gene	-8|compound|START_ENTITY -8|appos|END_ENTITY	Cholecystokinin -LRB- CCK -RRB- -8 - immunoreactivity in the piriform cortex of the rat with special reference to its fine structures .
9574843	0	Cholecystokinin	0,15	CCK	96,99	Cholecystokinin	CCK	MESH:D002766	885	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|overflow overflow|nmod|accumbens accumbens|nmod|END_ENTITY	Cholecystokinin increases extracellular dopamine overflow in the anterior nucleus accumbens via CCK -LRB- B -RRB- _ receptors in the VTA assessed by in vivo voltammetry .
16093397	0	Cholecystokinin	0,15	cholecystokinin_A_receptor	64,90	Cholecystokinin	cholecystokinin A receptor	MESH:D002766	12425(Tax:10090)	Chemical	Gene	activates|nsubj|START_ENTITY activates|nmod|END_ENTITY	Cholecystokinin activates orexin/hypocretin neurons through the cholecystokinin_A_receptor .
7787215	0	Cholecystokinin	0,15	gastrin	58,65	Cholecystokinin	gastrin	MESH:D002766	2520	Chemical	Gene	START_ENTITY|nmod|control control|nmod|END_ENTITY	Cholecystokinin in the control of gastric_acid and plasma gastrin and somatostatin secretion in healthy subjects and duodenal_ulcer patients before and after eradication of Helicobacter_pylori .
513954	0	Cholecystokinin	0,15	growth_hormone	37,51	Cholecystokinin	growth hormone	MESH:D002766	2688	Chemical	Gene	releases|compound|START_ENTITY END_ENTITY|nsubj|releases	Cholecystokinin octapeptide releases growth_hormone from the pituitary in vitro .
7820614	0	Cholecystokinin_octapeptide	0,27	CCK-B_receptor	107,121	Cholecystokinin octapeptide	CCK-B receptor	MESH:D012844	25706(Tax:10116)	Chemical	Gene	antagonizes|nsubj|START_ENTITY antagonizes|nmod|accumbens accumbens|nmod|rat rat|nmod|END_ENTITY	Cholecystokinin_octapeptide -LRB- CCK-8 -RRB- antagonizes morphine analgesia in nucleus accumbens of the rat via the CCK-B_receptor .
11940348	0	Cholecystokinin_octapeptide	0,27	CD14	64,68	Cholecystokinin octapeptide	CD14	MESH:D012844	60350(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Cholecystokinin_octapeptide inhibits the in vitro expression of CD14 in rat pulmonary interstitial macrophages induced by lipopolysaccharide .
18474570	0	Cholesterol	0,11	ABCA1	49,54	Cholesterol	ABCA1	MESH:D002784	11303(Tax:10090)	Chemical	Gene	A1|compound|START_ENTITY A1|appos|END_ENTITY	Cholesterol transporter ATP-binding cassette A1 -LRB- ABCA1 -RRB- is elevated in prion_disease and affects PrPC and PrPSc concentrations in cultured cells .
20229095	0	Cholesterol	0,11	ABCA1	60,65	Cholesterol	ABCA1	MESH:D002784	11303(Tax:10090)	Chemical	Gene	efflux|amod|START_ENTITY efflux|nmod|ATP-binding_cassette_transporter_A1 ATP-binding_cassette_transporter_A1|appos|END_ENTITY	Cholesterol efflux via ATP-binding_cassette_transporter_A1 -LRB- ABCA1 -RRB- and cholesterol uptake via the LDL_receptor influences cholesterol-induced impairment_of_beta cell function in mice .
23201557	0	Cholesterol	0,11	ABCA1	26,31	Cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	transport|amod|START_ENTITY transport|nmod|END_ENTITY	Cholesterol transport via ABCA1 : new insights from solid-phase binding assay .
25814677	0	Cholesterol	19,30	ABCA1	45,50	Cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	Efflux|compound|START_ENTITY Efflux|nmod|Pathway Pathway|compound|END_ENTITY	Small HDL Promotes Cholesterol Efflux by the ABCA1 Pathway in Macrophages : Implications for Therapies Targeted to HDL .
25838426	0	Cholesterol	9,20	ABCA1	112,117	Cholesterol	ABCA1	MESH:D002784	11303(Tax:10090)	Chemical	Gene	Ubiquitination|compound|START_ENTITY Ubiquitination|nmod|END_ENTITY	Cellular Cholesterol Accumulation Facilitates Ubiquitination and Lysosomal Degradation of Cell Surface-Resident ABCA1 .
26042209	0	Cholesterol	59,70	ABCA1	90,95	Cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	Diffusion|nmod|START_ENTITY Down-Regulates|nsubj|Diffusion Down-Regulates|dobj|Transporter Transporter|compound|END_ENTITY	Phosphatidylcholine-Mediated Aqueous Diffusion of Cellular Cholesterol Down-Regulates the ABCA1 Transporter in Human Skin Fibroblasts . ''
26102194	0	Cholesterol	18,29	ABCA1	53,58	Cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	Efflux|compound|START_ENTITY Enhanced|dobj|Efflux Enhanced|nmod|Expression Expression|compound|END_ENTITY	Curcumin Enhanced Cholesterol Efflux by Upregulating ABCA1 Expression Through AMPK-SIRT1-LXRa Signaling in THP-1 Macrophage-Derived Foam Cells .
12374760	0	Cholesterol	0,11	ABCD2	22,27	Cholesterol	ABCD2	MESH:D002784	225	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nummod|END_ENTITY	Cholesterol regulates ABCD2 expression : implications for the therapy of X-linked_adrenoleukodystrophy .
25732853	0	Cholesterol	0,11	ABCG1	27,32	Cholesterol	ABCG1	MESH:D002784	9619	Chemical	Gene	START_ENTITY|acl|sensing sensing|nmod|transporter transporter|compound|END_ENTITY	Cholesterol sensing by the ABCG1 lipid transporter : Requirement of a CRAC motif in the final transmembrane domain .
26489644	0	Cholesterol	48,59	ABCG1	0,5	Cholesterol	ABCG1	MESH:D002784	11307(Tax:10090)	Chemical	Gene	Levels|compound|START_ENTITY Levels|compound|END_ENTITY	ABCG1 Regulates Mouse Adipose Tissue Macrophage Cholesterol Levels and the Ratio of M1 to M2 Cells during Obesity and Caloric Restriction .
18668442	0	Cholesterol	0,11	ABCG5	53,58	Cholesterol	ABCG5	MESH:D002784	64240	Chemical	Gene	transporters|amod|START_ENTITY transporters|dep|END_ENTITY	Cholesterol and non-cholesterol_sterol transporters : ABCG5 , ABCG8 and NPC1L1 : a review .
17950700	0	Cholesterol	0,11	ACAT2	22,27	Cholesterol	ACAT2	MESH:D002784	39	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Cholesterol regulates ACAT2 gene expression and enzyme activity in human hepatoma cells .
20229095	0	Cholesterol	0,11	ATP-binding_cassette_transporter_A1	23,58	Cholesterol	ATP-binding cassette transporter A1	MESH:D002784	11303(Tax:10090)	Chemical	Gene	efflux|amod|START_ENTITY efflux|nmod|END_ENTITY	Cholesterol efflux via ATP-binding_cassette_transporter_A1 -LRB- ABCA1 -RRB- and cholesterol uptake via the LDL_receptor influences cholesterol-induced impairment_of_beta cell function in mice .
17616681	0	Cholesterol	0,11	Akt	56,59	Cholesterol	Akt	MESH:D002784	207	Chemical	Gene	sensitivity|amod|START_ENTITY sensitivity|nmod|END_ENTITY	Cholesterol sensitivity of endogenous and myristoylated Akt .
25415591	0	Cholesterol	39,50	ApoA-I	61,67	Cholesterol	ApoA-I	MESH:D002784	335	Chemical	Gene	Efflux|compound|START_ENTITY ABCA1-Mediated|dobj|Efflux ABCA1-Mediated|nmod|END_ENTITY	Akt Inhibition Promotes ABCA1-Mediated Cholesterol Efflux to ApoA-I through Suppressing mTORC1 .
26558782	0	Cholesterol	18,29	ApoE	46,50	Cholesterol	ApoE	MESH:D002784	348	Chemical	Gene	Homeostasis|compound|START_ENTITY Homeostasis|nmod|END_ENTITY	Daidzein Augments Cholesterol Homeostasis via ApoE to Promote Functional Recovery in Chronic_Stroke .
18590739	0	Cholesterol	0,11	BAX	23,26	Cholesterol	BAX	MESH:D002784	581	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|END_ENTITY	Cholesterol effects on BAX pore activation .
26597828	0	Cholesterol	24,35	C-Reactive_Protein	87,105	Cholesterol	C-Reactive Protein	MESH:D002784	1401	Chemical	Gene	Concentrations|compound|START_ENTITY Concentrations|nmod|Concentrations Concentrations|compound|END_ENTITY	Low-Density Lipoprotein Cholesterol Concentrations and Association of High-Sensitivity C-Reactive_Protein Concentrations With Incident Coronary_Heart_Disease in the Multi-Ethnic Study of Atherosclerosis .
15939816	0	Cholesterol	0,11	C-reactive_protein	30,48	Cholesterol	C-reactive protein	MESH:D002784	1401	Chemical	Gene	feeding|amod|START_ENTITY increases|nsubj|feeding increases|dobj|levels levels|amod|END_ENTITY	Cholesterol feeding increases C-reactive_protein and serum_amyloid_A levels in lean insulin-sensitive subjects .
26015437	0	Cholesterol	77,88	CETP	4,8	Cholesterol	CETP	MESH:D002784	1071	Chemical	Gene	Metabolism|compound|START_ENTITY Effect|nmod|Metabolism Expression|dep|Effect Expression|compound|END_ENTITY	New CETP Inhibitor K-312 Reduces PCSK9 Expression : A Potential Effect on LDL Cholesterol Metabolism .
26875987	0	Cholesterol	0,11	CLIC1	48,53	Cholesterol	CLIC1	MESH:D002784	1192	Chemical	Gene	Interaction|compound|START_ENTITY Interaction|nmod|END_ENTITY	Cholesterol Promotes Interaction of the Protein CLIC1 with Phospholipid Monolayers at the Air-Water Interface .
21576599	0	Cholesterol	0,11	CYP3A	41,46	Cholesterol	CYP3A	MESH:D002784	1576	Chemical	Gene	START_ENTITY|dobj|activity activity|nmod|END_ENTITY	Cholesterol 25-hydroxylation activity of CYP3A .
19212968	0	Cholesterol	0,11	CYP46A1	28,35	Cholesterol	CYP46A1	MESH:D002784	10858	Chemical	Gene	polymorphisms|amod|START_ENTITY polymorphisms|amod|24-hydroxylase 24-hydroxylase|dep|END_ENTITY	Cholesterol 24-hydroxylase -LRB- CYP46A1 -RRB- polymorphisms are associated with faster cognitive_deterioration in Chinese older persons : a two-year follow up study .
12907462	0	Cholesterol	0,11	ERK1/2	35,41	Cholesterol	ERK1/2	MESH:D002784	50689;116590	Chemical	Gene	dependence|amod|START_ENTITY dependence|nmod|END_ENTITY	Cholesterol dependence of vascular ERK1/2 activation and growth in response to stretch : role of endothelin-1 .
26543100	0	Cholesterol	20,31	Familial_Hypercholesterolemia	108,137	Cholesterol	Familial Hypercholesterolemia	MESH:D002784	3949	Chemical	Gene	Capacity|compound|START_ENTITY Capacity|nmod|Patients Patients|nmod|END_ENTITY	Association Between Cholesterol Efflux Capacity and Atherosclerotic_Cardiovascular_Disease in Patients With Familial_Hypercholesterolemia .
10170452	0	Cholesterol	44,55	HMG-CoA_reductase	92,109	Cholesterol	HMG-CoA reductase	MESH:D002784	3156	Chemical	Gene	Panel|compound|START_ENTITY treatment|nmod|Panel effectiveness|nmod|treatment targets|nsubj|effectiveness targets|nmod|inhibitors inhibitors|amod|END_ENTITY	Cost effectiveness of treatment to National Cholesterol Education Panel -LRB- NCEP -RRB- targets with HMG-CoA_reductase inhibitors .
26598836	0	Cholesterol	38,49	HMGCR	74,79	Cholesterol	HMGCR	MESH:D002784	3156	Chemical	Gene	Downstream|compound|START_ENTITY Downstream|nmod|END_ENTITY	Navigating the Shallows and Rapids of Cholesterol Synthesis Downstream of HMGCR .
26786161	0	Cholesterol	79,90	IDOL	42,46	Cholesterol	IDOL	MESH:D002784	29116	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Stable Liver-specific Expression of Human IDOL in Humanized Mice Raises Plasma Cholesterol .
26846634	0	Cholesterol	29,40	IDOL	8,12	Cholesterol	IDOL	MESH:D002784	29116	Chemical	Gene	Help|dobj|START_ENTITY Foiling|xcomp|Help Foiling|dobj|END_ENTITY	Foiling IDOL to Help Control Cholesterol .
25121926	0	Cholesterol	0,11	IL-5	34,38	Cholesterol	IL-5	MESH:D002784	3567	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Cholesterol selectively regulates IL-5 induced mitogen activated protein kinase signaling in human eosinophils .
26404254	0	Cholesterol	74,85	LDL_Receptor	96,108	Cholesterol	LDL Receptor	MESH:D002784	16835(Tax:10090)	Chemical	Gene	Levels|compound|START_ENTITY Treatment|nmod|Levels Treatment|nmod|Mice Mice|compound|END_ENTITY	Weekly Treatment of 2-Hydroxypropyl-b-cyclodextrin Improves Intracellular Cholesterol Levels in LDL_Receptor Knockout Mice .
25084760	0	Cholesterol	0,11	Liver_X_Receptor	56,72	Cholesterol	Liver X Receptor	MESH:D002784	22259(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|Pathway Pathway|compound|END_ENTITY	Cholesterol 24S-Hydroxylase Overexpression Inhibits the Liver_X_Receptor -LRB- LXR -RRB- Pathway by Activating Small Guanosine_Triphosphate-Binding Proteins -LRB- sGTPases -RRB- in Neuronal Cells .
17643435	0	Cholesterol	0,11	MMP-9	21,26	Cholesterol	MMP-9	MESH:D002784	4318	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Cholesterol inhibits MMP-9 expression in human epidermal keratinocytes and HaCaT cells .
9665761	0	Cholesterol	48,59	Myelin_Basic_Protein	22,42	Cholesterol	Myelin Basic Protein	MESH:D002784	618684(Tax:9913)	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of Bovine Myelin_Basic_Protein with Cholesterol .
20668705	0	Cholesterol	0,11	NLRP3	34,39	Cholesterol	NLRP3	MESH:D002784	114548	Chemical	Gene	crystals|amod|START_ENTITY activate|nsubj|crystals activate|dobj|inflammasome inflammasome|compound|END_ENTITY	Cholesterol crystals activate the NLRP3 inflammasome in human macrophages : a novel link between cholesterol metabolism and inflammation .
18585981	0	Cholesterol	0,11	NPC1L1	79,85	Cholesterol	NPC1L1	MESH:D002784	237636(Tax:10090)	Chemical	Gene	homeostasis|amod|START_ENTITY homeostasis|dep|lessons lessons|nmod|END_ENTITY	Cholesterol homeostasis by the intestine : lessons from Niemann-Pick_C1_Like_1 -LSB- NPC1L1 -RRB- .
18599618	0	Cholesterol	164,175	NUR77	28,33	Cholesterol	NUR77	MESH:D002784	3164	Chemical	Gene	transport|nsubj|START_ENTITY kinase|ccomp|transport mediated|dep|kinase containing|parataxis|mediated +|acl|containing Leydig|nmod|+ regulates|advcl|Leydig regulates|nsubj|END_ENTITY	The orphan nuclear receptor NUR77 regulates hormone-induced StAR transcription in Leydig cells through cooperation with Ca2 + / calmodulin-dependent protein kinase I. Cholesterol transport in the mitochondrial membrane , an essential step of steroid biosynthesis , is mediated by a protein complex containing the steroidogenic_acute_regulatory -LRB- StAR -RRB- protein .
11027568	0	Cholesterol	0,11	P-glycoprotein	62,76	Cholesterol	P-glycoprotein	MESH:D002784	5243	Chemical	Gene	interaction|amod|START_ENTITY interaction|nmod|site site|nmod|END_ENTITY	Cholesterol interaction with the daunorubicin binding site of P-glycoprotein .
15033457	0	Cholesterol	0,11	P-glycoprotein	22,36	Cholesterol	P-glycoprotein	MESH:D002784	5243	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activity activity|amod|END_ENTITY	Cholesterol modulates P-glycoprotein activity in human peripheral blood mononuclear cells .
24993279	0	Cholesterol	54,65	PCSK9	0,5	Cholesterol	PCSK9	MESH:D002784	255738	Chemical	Gene	Uptake|nmod|START_ENTITY Yin-Yang|nmod|Uptake END_ENTITY|dep|Yin-Yang	PCSK9 and LDLR The Yin-Yang in the Cellular Uptake of Cholesterol .
25412415	0	Cholesterol	80,91	PCSK9	33,38	Cholesterol	PCSK9	MESH:D002784	255738	Chemical	Gene	Level|compound|START_ENTITY Level|compound|END_ENTITY	Both Rare and Common Variants in PCSK9 Influence Plasma Low-Density Lipoprotein Cholesterol Level in American Indians .
26015437	0	Cholesterol	77,88	PCSK9	33,38	Cholesterol	PCSK9	MESH:D002784	255738	Chemical	Gene	Metabolism|compound|START_ENTITY Effect|nmod|Metabolism Expression|dep|Effect Expression|compound|END_ENTITY	New CETP Inhibitor K-312 Reduces PCSK9 Expression : A Potential Effect on LDL Cholesterol Metabolism .
26624842	0	Cholesterol	35,46	PCSK9	0,5	Cholesterol	PCSK9	MESH:D002784	255738	Chemical	Gene	Inhibitors|nmod|START_ENTITY Inhibitors|compound|END_ENTITY	PCSK9 Inhibitors for Treating High Cholesterol .
26662572	0	Cholesterol	87,98	PCSK9	47,52	Cholesterol	PCSK9	MESH:D002784	255738	Chemical	Gene	Levels|compound|START_ENTITY Treatment|nmod|Levels Inhibitors|nmod|Treatment Inhibitors|appos|END_ENTITY	Proprotein_Convertase_Subtilisin / Kexin_Type_9 -LRB- PCSK9 -RRB- Inhibitors for Treatment of High Cholesterol Levels : Effectiveness and Value .
26702335	0	Cholesterol	72,83	PCSK9	7,12	Cholesterol	PCSK9	MESH:D002784	255738	Chemical	Gene	Control|compound|START_ENTITY Stack|nmod|Control Stack|nsubj|Inhibitors Inhibitors|compound|END_ENTITY	How Do PCSK9 Inhibitors Stack Up to Statins for Low-Density Lipoprotein Cholesterol Control ?
26317415	0	Cholesterol	53,64	Reelin	15,21	Cholesterol	Reelin	MESH:D002784	5649	Chemical	Gene	Accumulation|compound|START_ENTITY Accumulation|compound|END_ENTITY	A Subregion of Reelin Suppresses Lipoprotein-Induced Cholesterol Accumulation in Macrophages .
12957864	0	Cholesterol	0,11	SR-BI	55,60	Cholesterol	SR-BI	MESH:D002784	949	Chemical	Gene	uptake|amod|START_ENTITY uptake|dep|pathway pathway|amod|selective selective|dep|END_ENTITY	Cholesterol uptake in adrenal and gonadal tissues : the SR-BI and ` selective ' pathway connection .
25211142	0	Cholesterol	84,95	SR-BI	65,70	Cholesterol	SR-BI	MESH:D002784	949	Chemical	Gene	Transport|compound|START_ENTITY Critical|nmod|Transport Critical|compound|END_ENTITY	SR-BI/CD36 Chimeric Receptors Define Extracellular Subdomains of SR-BI Critical for Cholesterol Transport .
22582093	0	Cholesterol	54,65	Soluble_Epoxide_Hydrolase	14,39	Cholesterol	Soluble Epoxide Hydrolase	MESH:D002784	2053	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Novel Role of Soluble_Epoxide_Hydrolase in Regulating Cholesterol in Mammalian Cells .
17301050	0	Cholesterol	0,11	StAR	93,97	Cholesterol	StAR	MESH:D002784	6770	Chemical	Gene	binding|compound|START_ENTITY predict|nsubj|binding predict|dobj|activity activity|nmod|steroidogenic_acute_regulatory_protein steroidogenic_acute_regulatory_protein|appos|END_ENTITY	Cholesterol binding does not predict activity of the steroidogenic_acute_regulatory_protein , StAR .
18331352	0	Cholesterol	0,11	StAR	106,110	Cholesterol	StAR	MESH:D002784	6770	Chemical	Gene	interaction|amod|START_ENTITY domains|nsubj|interaction domains|nmod|END_ENTITY	Cholesterol interaction with the related steroidogenic acute regulatory lipid-transfer -LRB- START -RRB- domains of StAR -LRB- STARD1 -RRB- and MLN64 -LRB- STARD3 -RRB- .
18341481	0	Cholesterol	0,11	StAR	102,106	Cholesterol	StAR	MESH:D002784	6770	Chemical	Gene	binding|compound|START_ENTITY prerequisite|nsubj|binding prerequisite|nmod|activity activity|nmod|steroidogenic_acute_regulatory_protein steroidogenic_acute_regulatory_protein|appos|END_ENTITY	Cholesterol binding is a prerequisite for the activity of the steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- .
18599618	0	Cholesterol	164,175	StAR	60,64	Cholesterol	StAR	MESH:D002784	6770	Chemical	Gene	transport|nsubj|START_ENTITY kinase|ccomp|transport mediated|dep|kinase containing|parataxis|mediated +|acl|containing Leydig|nmod|+ regulates|advcl|Leydig regulates|dobj|transcription transcription|compound|END_ENTITY	The orphan nuclear receptor NUR77 regulates hormone-induced StAR transcription in Leydig cells through cooperation with Ca2 + / calmodulin-dependent protein kinase I. Cholesterol transport in the mitochondrial membrane , an essential step of steroid biosynthesis , is mediated by a protein complex containing the steroidogenic_acute_regulatory -LRB- StAR -RRB- protein .
26901662	0	Cholesterol	81,92	Sterol_Carrier_Protein-2	0,24	Cholesterol	Sterol Carrier Protein-2	MESH:D002784	20280(Tax:10090)	Chemical	Gene	Trafficking|compound|START_ENTITY END_ENTITY|nmod|Trafficking	Sterol_Carrier_Protein-2 , a Nonspecific_Lipid-Transfer_Protein , in Intracellular Cholesterol Trafficking in Testicular Leydig Cells .
16013454	0	Cholesterol	0,11	THP-1	72,77	Cholesterol	THP-1	MESH:D002784	2736	Chemical	Gene	regulation|amod|START_ENTITY involved|nsubj|regulation involved|nmod|macrophages macrophages|compound|END_ENTITY	Cholesterol regulation of genes involved in sterol trafficking in human THP-1 macrophages .
24396573	0	Cholesterol	62,73	THP-1	89,94	Cholesterol	THP-1	MESH:D002784	2736	Chemical	Gene	Homeostasis|compound|START_ENTITY Homeostasis|nmod|Macrophages Macrophages|compound|END_ENTITY	The Effect of Unsaturated Fatty_Acids on Molecular Markers of Cholesterol Homeostasis in THP-1 Macrophages .
25130461	0	Cholesterol	0,11	THP-1	24,29	Cholesterol	THP-1	MESH:D002784	2736	Chemical	Gene	efflux|amod|START_ENTITY efflux|nmod|macrophages macrophages|compound|END_ENTITY	Cholesterol efflux from THP-1 macrophages is impaired by the fatty_acid component from lipoprotein hydrolysis by lipoprotein lipase .
25989518	0	Cholesterol	60,71	THP-1	122,127	Cholesterol	THP-1	MESH:D002784	2736	Chemical	Gene	Efflux|compound|START_ENTITY Efflux|nmod|Macrophages Macrophages|compound|END_ENTITY	The Effects of Phellinus linteus Polysaccharide Extracts on Cholesterol Efflux in Oxidized Low-Density Lipoprotein-Loaded THP-1 Macrophages .
25989518	0	Cholesterol	60,71	THP-1	122,127	Cholesterol	THP-1	MESH:D002784	2736	Chemical	Gene	Efflux|compound|START_ENTITY Efflux|nmod|Macrophages Macrophages|compound|END_ENTITY	The Effects of Phellinus linteus Polysaccharide Extracts on Cholesterol Efflux in Oxidized Low-Density Lipoprotein-Loaded THP-1 Macrophages .
26102194	0	Cholesterol	18,29	THP-1	107,112	Cholesterol	THP-1	MESH:D002784	2736	Chemical	Gene	Efflux|compound|START_ENTITY Enhanced|dobj|Efflux Enhanced|nmod|Signaling Signaling|nmod|Cells Cells|compound|END_ENTITY	Curcumin Enhanced Cholesterol Efflux by Upregulating ABCA1 Expression Through AMPK-SIRT1-LXRa Signaling in THP-1 Macrophage-Derived Foam Cells .
9763531	0	Cholesterol	0,11	THP-1	43,48	Cholesterol	THP-1	MESH:D002784	2736	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|nmod|END_ENTITY	Cholesterol metabolism and efflux in human THP-1 macrophages .
26774178	0	Cholesterol	55,66	Transmembrane_6_Superfamily_Member_2	8,44	Cholesterol	Transmembrane 6 Superfamily Member 2	MESH:D002784	107770(Tax:10090)	Chemical	Gene	Metabolism|compound|START_ENTITY Regulates|dobj|Metabolism Regulates|nsubj|END_ENTITY	Hepatic Transmembrane_6_Superfamily_Member_2 Regulates Cholesterol Metabolism in Mice .
26890002	0	Cholesterol	32,43	UBIAD1	8,14	Cholesterol	UBIAD1	MESH:D002784	29914	Chemical	Gene	Metabolism|compound|START_ENTITY Role|nmod|Metabolism Role|nmod|END_ENTITY	Role of UBIAD1 in Intracellular Cholesterol Metabolism and Vascular Cell Calcification .
12093337	0	Cholesterol	0,11	albumin	22,29	Cholesterol	albumin	MESH:D002784	213	Chemical	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	Cholesterol and serum albumin levels as predictors of cross_infection , death , and length of hospital stay .
19965585	0	Cholesterol	0,11	apoA-I	22,28	Cholesterol	apoA-I	MESH:D002784	335	Chemical	Gene	efflux|amod|START_ENTITY efflux|nmod|END_ENTITY	Cholesterol efflux to apoA-I in ABCA1-expressing cells is regulated by Ca2 + - dependent calcineurin signaling .
23826352	0	Cholesterol	90,101	apoA-I	10,16	Cholesterol	apoA-I	MESH:D002784	335	Chemical	Gene	Efflux|compound|START_ENTITY HDL|nmod|Efflux Effect|nmod|HDL Effect|nmod|Mutations Mutations|compound|END_ENTITY	Effect of apoA-I Mutations in the Capacity of Reconstituted HDL to Promote ABCG1-Mediated Cholesterol Efflux .
1402403	0	Cholesterol	0,11	apoE	139,143	Cholesterol	apoE	MESH:D002784	348	Chemical	Gene	absorption|amod|START_ENTITY related|nsubj|absorption related|nmod|intake intake|nmod|men men|nmod|phenotypes phenotypes|compound|END_ENTITY	Cholesterol absorption and synthesis related to low density lipoprotein metabolism during varying cholesterol intake in men with different apoE phenotypes .
18406360	0	Cholesterol	0,11	apolipoprotein_A-I	144,162	Cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	determinant|nsubj|START_ENTITY determinant|nmod|structures structures|nmod|lipoproteins lipoproteins|acl|formed formed|nmod|END_ENTITY	Cholesterol is a determinant of the structures of discoidal high density lipoproteins formed by the solubilization of phospholipid membranes by apolipoprotein_A-I .
9047326	0	Cholesterol	0,11	apolipoprotein_A-I	119,137	Cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	efflux|amod|START_ENTITY efflux|nmod|END_ENTITY	Cholesterol efflux , lecithin-cholesterol_acyltransferase activity , and pre-beta particle formation by serum from human apolipoprotein_A-I and apolipoprotein_A-I / apolipoprotein_A-II transgenic_mice consistent with the latter being less effective for reverse cholesterol transport .
10500181	0	Cholesterol	0,11	apolipoprotein_AI	22,39	Cholesterol	apolipoprotein AI	MESH:D002784	11806(Tax:10090)	Chemical	Gene	efflux|amod|START_ENTITY efflux|nmod|END_ENTITY	Cholesterol efflux to apolipoprotein_AI involves endocytosis and resecretion in a calcium-dependent pathway .
17379671	0	Cholesterol	0,11	apolipoprotein_E	53,69	Cholesterol	apolipoprotein E	MESH:D002784	348	Chemical	Gene	moderate|nsubj|START_ENTITY moderate|dobj|effect effect|nmod|END_ENTITY	Cholesterol and triglycerides moderate the effect of apolipoprotein_E on memory functioning in older adults .
17495608	0	Cholesterol	0,11	apolipoprotein_E	24,40	Cholesterol	apolipoprotein E	MESH:D002784	11816(Tax:10090)	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|appos|END_ENTITY	Cholesterol metabolism , apolipoprotein_E , adenosine_triphosphate-binding cassette transporters , and Alzheimer 's _ disease .
2027015	0	Cholesterol	0,11	apolipoprotein_E	91,107	Cholesterol	apolipoprotein E	MESH:D002784	25728(Tax:10116)	Chemical	Gene	becomes|nsubj|START_ENTITY becomes|xcomp|associated associated|nmod|lipoproteins lipoproteins|acl|containing containing|dobj|END_ENTITY	Cholesterol from degenerating nerve myelin becomes associated with lipoproteins containing apolipoprotein_E .
22747346	0	Cholesterol	0,11	apolipoprotein_E	90,106	Cholesterol	apolipoprotein E	MESH:D002784	348	Chemical	Gene	accumulation|amod|START_ENTITY inhibits|nsubj|accumulation inhibits|parataxis|studies studies|nmod|END_ENTITY	Cholesterol accumulation inhibits ER to Golgi transport and protein secretion : studies of apolipoprotein_E and VSVGt .
9664080	0	Cholesterol	0,11	apolipoprotein_E	86,102	Cholesterol	apolipoprotein E	MESH:D002784	11816(Tax:10090)	Chemical	Gene	START_ENTITY|acl|lowering lowering|advcl|overexpressing overexpressing|dobj|END_ENTITY	Cholesterol lowering in low_density_lipoprotein_receptor knockout mice overexpressing apolipoprotein_E .
25049985	0	Cholesterol	0,11	b-Cyclodextrin	50,64	Cholesterol	b-Cyclodextrin	MESH:D002784	285440	Chemical	Gene	Removal|compound|START_ENTITY Removal|nmod|END_ENTITY	Cholesterol Removal from Whole Egg by Crosslinked b-Cyclodextrin .
8139578	0	Cholesterol	0,11	cholesterol_7_alpha-hydroxylase	36,67	Cholesterol	cholesterol 7 alpha-hydroxylase	MESH:D002784	13122(Tax:10090)	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|amod|END_ENTITY	Cholesterol and bile_acids regulate cholesterol_7_alpha-hydroxylase expression at the transcriptional level in culture and in transgenic_mice .
6747463	0	Cholesterol	0,11	cholesterol_esterase	49,69	Cholesterol	cholesterol esterase	MESH:D002784	24254(Tax:10116)	Chemical	Gene	absorption|amod|START_ENTITY absorption|dep|role role|nmod|A A|amod|END_ENTITY	Cholesterol absorption in rat intestine : role of cholesterol_esterase and acyl coenzyme A : cholesterol acyltransferase .
8675626	0	Cholesterol	0,11	cholesteryl_ester_transfer_protein	64,98	Cholesterol	cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	potential|amod|START_ENTITY potential|nmod|sera sera|nmod|mice mice|acl|expressing expressing|dobj|END_ENTITY	Cholesterol efflux potential of sera from mice expressing human cholesteryl_ester_transfer_protein and/or human apolipoprotein_AI .
15736936	0	Cholesterol	0,11	cytochrome_P450_7A1	23,42	Cholesterol	cytochrome P450 7A1	MESH:D002784	1581	Chemical	Gene	START_ENTITY|xcomp|binding binding|nmod|END_ENTITY	Cholesterol binding to cytochrome_P450_7A1 , a key enzyme in bile_acid biosynthesis .
21576826	0	Cholesterol	0,11	endoglin	23,31	Cholesterol	endoglin	MESH:D002784	13805(Tax:10090)	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|END_ENTITY	Cholesterol effects on endoglin and its downstream pathways in ApoE/LDLR double knockout mice .
3769200	0	Cholesterol	0,11	familial_hypercholesterolemia	93,122	Cholesterol	familial hypercholesterolemia	MESH:D002784	3949	Chemical	Gene	efflux|amod|START_ENTITY fibroblasts|nsubj|efflux fibroblasts|nmod|patients patients|nmod|END_ENTITY	Cholesterol efflux from cultured skin fibroblasts in 12 patients clinically heterozygous for familial_hypercholesterolemia .
16793657	0	Cholesterol	0,11	fibrinogen	56,66	Cholesterol	fibrinogen	MESH:D002784	2244	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Cholesterol enhances the adhesion of human platelets to fibrinogen : studies using a novel fluorescence based assay .
10195906	0	Cholesterol	0,11	growth_hormone	85,99	Cholesterol	growth hormone	MESH:D002784	81668(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|dep|reversal reversal|nmod|hypercholesterolemia hypercholesterolemia|nmod|treatment treatment|amod|END_ENTITY	Cholesterol and lipoprotein metabolism in aging : reversal of hypercholesterolemia by growth_hormone treatment in old rats .
12586063	0	Cholesterol	0,11	hedgehog	28,36	Cholesterol	hedgehog	MESH:D002784	42737(Tax:7227)	Chemical	Gene	modification|amod|START_ENTITY modification|nmod|END_ENTITY	Cholesterol modification of hedgehog is required for trafficking and movement , revealing an asymmetric cellular response to hedgehog .
19783832	0	Cholesterol	0,11	idol	27,31	Cholesterol	idol	MESH:D002784	29116	Chemical	Gene	worships|nsubj|START_ENTITY worships|dobj|END_ENTITY	Cholesterol worships a new idol .
15935563	0	Cholesterol	0,11	interleukin-6	62,75	Cholesterol	interleukin-6	MESH:D002784	3569	Chemical	Gene	synthesis|amod|START_ENTITY diabetes|nsubj|synthesis diabetes|dep|trigger trigger|dobj|inflammation inflammation|amod|END_ENTITY	Cholesterol synthesis is the trigger and isoprenoid dependent interleukin-6 mediated inflammation is the common causative factor and therapeutic target for atherosclerotic_vascular_disease and age-related_disorders including osteoporosis and type 2 diabetes .
23298460	0	Cholesterol	0,11	low-density_lipoprotein_receptor	104,136	Cholesterol	low-density lipoprotein receptor	MESH:D002784	16835(Tax:10090)	Chemical	Gene	reduction|amod|START_ENTITY ameliorates|nsubj|reduction ameliorates|nmod|islets islets|nmod|mice mice|amod|END_ENTITY	Cholesterol reduction ameliorates glucose-induced calcium handling and insulin secretion in islets from low-density_lipoprotein_receptor knockout mice .
24286458	0	Cholesterol	0,11	low_density_lipoprotein_receptor	35,67	Cholesterol	low density lipoprotein receptor	MESH:D002784	16835(Tax:10090)	Chemical	Gene	accumulation|amod|START_ENTITY caused|nsubj|accumulation caused|nmod|deficiency deficiency|compound|END_ENTITY	Cholesterol accumulation caused by low_density_lipoprotein_receptor deficiency or a cholesterol-rich diet results in ectopic bone formation during experimental osteoarthritis .
6491537	0	Cholesterol	0,11	low_density_lipoprotein_receptor	81,113	Cholesterol	low density lipoprotein receptor	MESH:D002784	3949	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|acl|lacking lacking|dobj|pathway pathway|amod|END_ENTITY	Cholesterol metabolism in pigeon aortic smooth muscle cells lacking a functional low_density_lipoprotein_receptor pathway .
9664080	0	Cholesterol	0,11	low_density_lipoprotein_receptor	24,56	Cholesterol	low density lipoprotein receptor	MESH:D002784	16835(Tax:10090)	Chemical	Gene	START_ENTITY|acl|lowering lowering|nmod|mice mice|compound|END_ENTITY	Cholesterol lowering in low_density_lipoprotein_receptor knockout mice overexpressing apolipoprotein_E .
25814681	0	Cholesterol	0,11	miR-223	38,45	Cholesterol	miR-223	MESH:D002784	407008	Chemical	Gene	Regulation|compound|START_ENTITY Regulation|nmod|END_ENTITY	Cholesterol Homeostasis Regulation by miR-223 : Basic Science Mechanisms and Translational Implications .
8218286	0	Cholesterol	0,11	pancreatic_cholesterol_esterase	34,65	Cholesterol	pancreatic cholesterol esterase	MESH:D002784	1056	Chemical	Gene	function|amod|START_ENTITY function|nmod|END_ENTITY	Cholesterol transport function of pancreatic_cholesterol_esterase : directed sterol uptake and esterification in enterocytes .
21285396	0	Cholesterol	0,11	receptor-interacting_protein_140	26,58	Cholesterol	receptor-interacting protein 140	MESH:D002784	8204	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Cholesterol regulation of receptor-interacting_protein_140 via microRNA-33 in inflammatory cytokine production .
8577222	0	Cholesterol	0,11	sterol_carrier_protein-2	47,71	Cholesterol	sterol carrier protein-2	MESH:D002784	6342	Chemical	Gene	interaction|nsubj|START_ENTITY interaction|nmod|END_ENTITY	Cholesterol interaction with recombinant human sterol_carrier_protein-2 .
16039291	0	Cholesterol_ester	0,17	CETP	36,40	Cholesterol ester	CETP	CHEBI:17002	1071	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Cholesterol_ester transfer protein -LRB- CETP -RRB- Taq1B polymorphism influences the effect of a standardized cardiac rehabilitation program on lipid risk markers .
19835569	0	Cholesterol_ester	0,17	CETP	36,40	Cholesterol ester	CETP	CHEBI:17002	1071	Chemical	Gene	transfer|nsubj|START_ENTITY transfer|dobj|protein protein|appos|END_ENTITY	Cholesterol_ester transfer protein -LRB- CETP -RRB- , postprandial_lipemia and hypolipidemic drugs .
7853706	0	Cholesterol_ester	1,18	CETP	37,41	Cholesterol ester	CETP	CHEBI:17002	1071	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	-LSB- Cholesterol_ester transfer protein -LRB- CETP -RRB- -RSB- .
26758205	0	Cholesteryl_Ester	0,17	CETP	129,133	Cholesteryl Ester	CETP	D002788	1071	Chemical	Gene	Protein|compound|START_ENTITY Protein|dep|studies studies|nmod|transgenic_mice transgenic_mice|compound|END_ENTITY	Cholesteryl_Ester Transfer Protein -LRB- CETP -RRB- expression does not affect glucose homeostasis and insulin secretion : studies in human CETP transgenic_mice .
26758205	0	Cholesteryl_Ester	0,17	CETP	36,40	Cholesteryl Ester	CETP	D002788	1071	Chemical	Gene	Protein|compound|START_ENTITY Protein|appos|END_ENTITY	Cholesteryl_Ester Transfer Protein -LRB- CETP -RRB- expression does not affect glucose homeostasis and insulin secretion : studies in human CETP transgenic_mice .
20936097	0	Cholesteryl_Glucoside_Stimulates	0,32	Protein_Kinase_B	47,63	Cholesteryl Glucoside Stimulates	Protein Kinase B	null	2185	Chemical	Gene	Activation|compound|START_ENTITY Activation|nmod|END_ENTITY	Cholesteryl_Glucoside_Stimulates Activation of Protein_Kinase_B / Akt in the Motor Neuron-Derived NSC34 Cell Line .
15888337	0	Cholesteryl_ester	0,17	CETP	36,40	Cholesteryl ester	CETP	null	1071	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Cholesteryl_ester transfer protein -LRB- CETP -RRB- I405V polymorphism and longevity in Italian centenarians .
16096813	0	Cholesteryl_ester	0,17	CETP	36,40	Cholesteryl ester	CETP	null	1071	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Cholesteryl_ester transfer protein -LRB- CETP -RRB- polymorphism modifies the Alzheimer 's _ disease risk associated with APOE epsilon4 allele .
16439711	0	Cholesteryl_ester	0,17	CETP	36,40	Cholesteryl ester	CETP	null	1071	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Cholesteryl_ester transfer protein -LRB- CETP -RRB- inhibition beyond raising high-density lipoprotein cholesterol levels : pathways by which modulation of CETP activity may alter atherogenesis .
17055779	0	Cholesteryl_ester	0,17	CETP	36,40	Cholesteryl ester	CETP	null	1071	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Cholesteryl_ester transfer protein -LRB- CETP -RRB- expression enhances HDL cholesteryl_ester liver delivery , which is independent of scavenger_receptor_BI , LDL_receptor related protein and possibly LDL_receptor .
17272756	0	Cholesteryl_ester	0,17	CETP	36,40	Cholesteryl ester	CETP	null	1071	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Cholesteryl_ester transfer protein -LRB- CETP -RRB- expression protects against diet induced atherosclerosis in SR-BI deficient mice .
18637884	0	Cholesteryl_ester	0,17	CETP	36,40	Cholesteryl ester	CETP	null	1071	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Cholesteryl_ester transfer protein -LRB- CETP -RRB- genetic variation and early onset of non-fatal myocardial_infarction .
18929230	0	Cholesteryl_ester	0,17	CETP	36,40	Cholesteryl ester	CETP	null	1071	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Cholesteryl_ester transfer protein -LRB- CETP -RRB- inhibitors : is there life after torcetrapib ?
19191759	0	Cholesteryl_ester	0,17	CETP	36,40	Cholesteryl ester	CETP	null	1071	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Cholesteryl_ester transfer protein -LRB- CETP -RRB- increases postprandial triglyceridaemia and delays triacylglycerol plasma clearance in transgenic_mice .
22729881	0	Cholesteryl_ester	0,17	CETP	36,40	Cholesteryl ester	CETP	null	1071	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Cholesteryl_ester transfer protein -LRB- CETP -RRB- -629 C/A polymorphism and it 's effects on the serum lipid levels in metabolic_syndrome patients .
8847481	0	Cholesteryl_ester	0,17	CETP	36,40	Cholesteryl ester	CETP	null	1071	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Cholesteryl_ester transfer protein -LRB- CETP -RRB- mRNA abundance in human adipose tissue : relationship to cell size and membrane cholesterol content .
19424097	0	Choline	0,7	BDNF	21,25	Choline	BDNF	MESH:D002794	24225(Tax:10116)	Chemical	Gene	up-regulates|amod|START_ENTITY END_ENTITY|nsubj|up-regulates	Choline up-regulates BDNF and down-regulates TrkB neurotrophin receptor in rat cortical cell culture .
20392695	0	Choline	0,7	alpha4	36,42	Choline	alpha4	MESH:D002794	3476	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|END_ENTITY	Choline promotes nicotinic receptor alpha4 + beta2 up-regulation .
638328	0	Choline	0,7	choline_acetyltransferase	16,41	Choline	choline acetyltransferase	MESH:D002794	395314(Tax:9031)	Chemical	Gene	proceedings|amod|START_ENTITY proceedings|amod|END_ENTITY	Choline uptake , choline_acetyltransferase and the acetylation of choline in chick and rat brain -LSB- proceedings -RSB- .
22025560	0	Choline	0,7	choline_kinase_a	59,75	Choline	choline kinase a	MESH:D002794	1119	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Choline phosphorylation and regulation of transcription of choline_kinase_a in hypoxia .
15485505	0	Choline	0,7	vesicular_acetylcholine_transporter	26,61	Choline	vesicular acetylcholine transporter	MESH:D002794	60422(Tax:10116)	Chemical	Gene	transported|nsubjpass|START_ENTITY transported|nmod|END_ENTITY	Choline is transported by vesicular_acetylcholine_transporter .
10983891	0	Chromium	0,8	ICAM-1	55,61	Chromium	ICAM-1	MESH:D002857	3383	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Chromium -LRB- VI -RRB- increases endothelial cell expression of ICAM-1 and decreases nitric_oxide activity .
25346863	0	Chromium	0,8	Insulin	21,28	Chromium	Insulin	MESH:D002857	3630	Chemical	Gene	Therapy|compound|START_ENTITY Therapy|nmod|Associated Associated|compound|END_ENTITY	Chromium Therapy for Insulin Resistance Associated with HIV-Disease .
18595867	0	Chromium	0,8	insulin	35,42	Chromium	insulin	MESH:D002857	3630	Chemical	Gene	infusion|amod|START_ENTITY reverses|nsubj|infusion reverses|dobj|resistance resistance|compound|END_ENTITY	Chromium infusion reverses extreme insulin resistance in a cardiothoracic ICU patient .
22297054	0	Chromium	0,8	insulin	55,62	Chromium	insulin	MESH:D002857	3630	Chemical	Gene	infusion|amod|START_ENTITY infusion|nmod|patients patients|nmod|resistance resistance|compound|END_ENTITY	Chromium infusion in hospitalized patients with severe insulin resistance : a retrospective analysis .
6350814	0	Chromium	0,8	insulin	64,71	Chromium	insulin	MESH:D002857	3630	Chemical	Gene	supplementation|amod|START_ENTITY supplementation|dep|effects effects|nmod|END_ENTITY	Chromium supplementation of human subjects : effects on glucose , insulin , and lipid variables .
15823722	0	Chromium_picolinate	0,19	insulin	116,123	Chromium picolinate	insulin	MESH:C030614	3630	Chemical	Gene	influence|nsubj|START_ENTITY influence|dobj|risk risk|acl|associated associated|advcl|combating combating|dobj|resistance resistance|compound|END_ENTITY	Chromium_picolinate may favorably influence the vascular risk associated with smoking by combating cortisol-induced insulin resistance .
16730719	0	Chromium_picolinate	0,19	insulin	29,36	Chromium picolinate	insulin	MESH:C030614	3630	Chemical	Gene	improves|nsubj|START_ENTITY improves|dobj|sensitivity sensitivity|compound|END_ENTITY	Chromium_picolinate improves insulin sensitivity in obese subjects with polycystic_ovary_syndrome .
18190429	0	Chromium_picolinate	0,19	insulin	24,31	Chromium picolinate	insulin	MESH:C030614	3630	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	Chromium_picolinate for insulin resistance in subjects with HIV_disease : a pilot study .
26663540	0	Chromium_picolinate	0,19	insulin	28,35	Chromium picolinate	insulin	MESH:C030614	3630	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|resistance resistance|compound|END_ENTITY	Chromium_picolinate reduces insulin resistance in polycystic_ovary_syndrome : Randomized controlled trial .
23166555	0	Chrysin	10,17	Mucin	62,67	Chrysin	Mucin	MESH:C043561	100508689	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of Chrysin on Gene Expression and Production of MUC5AC Mucin from Cultured Airway Epithelial Cells .
22991264	0	Chrysin	0,7	Notch1	18,24	Chrysin	Notch1	MESH:C043561	18128(Tax:10090)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Chrysin activates Notch1 signaling and suppresses tumor growth of anaplastic_thyroid_carcinoma in vitro and in vivo .
23636231	0	Chrysin	0,7	TRAIL	18,23	Chrysin	TRAIL	MESH:C043561	8743	Chemical	Gene	overcomes|nsubj|START_ENTITY overcomes|dobj|resistance resistance|amod|END_ENTITY	Chrysin overcomes TRAIL resistance of cancer cells through Mcl-1 downregulation by inhibiting STAT3 phosphorylation .
15670832	0	Chrysin	0,7	cyclooxygenase-2	46,62	Chrysin	cyclooxygenase-2	MESH:C043561	19225(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Chrysin suppresses lipopolysaccharide-induced cyclooxygenase-2 expression through the inhibition of nuclear factor for IL-6 -LRB- NF-IL6 -RRB- DNA-binding activity .
23134323	0	Chrysin	0,7	histone_deacetylase_8	11,32	Chrysin	histone deacetylase 8	MESH:C043561	55869	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Chrysin : a histone_deacetylase_8 inhibitor with anticancer activity and a suitable candidate for the standardization of Chinese_propolis .
24876671	0	Chrysophanol	0,12	NALP3	22,27	Chrysophanol	NALP3	MESH:C027113	216799(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|compound|END_ENTITY	Chrysophanol inhibits NALP3 inflammasome activation and ameliorates cerebral_ischemia / reperfusion in mice .
25173752	0	Chylomicron	45,56	Glucagon-Like_Peptide_2	0,23	Chylomicron	Glucagon-Like Peptide 2	null	2641	Chemical	Gene	Release|nmod|START_ENTITY Release|compound|END_ENTITY	Glucagon-Like_Peptide_2 Regulates Release of Chylomicron from the Intestine .
1900217	0	Ciamexone	66,75	interferon_gamma	17,33	Ciamexone	interferon gamma	MESH:C035520	3458	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|inhibition inhibition|nmod|END_ENTITY	No inhibition of interferon_gamma release in human lymphocytes by Ciamexone .
6257659	0	Cibacron_Blue_F3GA	10,28	phosphoglycerate_kinase	32,55	Cibacron Blue F3GA	phosphoglycerate kinase	MESH:C012842	850370(Tax:4932)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of Cibacron_Blue_F3GA on phosphoglycerate_kinase of Lactobacillus_plantarum and phosphoglycerate mutase of Leuconostoc dextranicum .
22246000	0	Ciclesonide	0,11	TNFa	21,25	Ciclesonide	TNFa	MESH:C120481	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Ciclesonide inhibits TNFa - and IL-1b-induced monocyte_chemotactic_protein-1 -LRB- MCP-1 / CCL2 -RRB- secretion from human airway_smooth_muscle cells .
25294812	0	Ciclopirox	0,10	JNK	84,87	Ciclopirox	JNK	MESH:C011585	5599	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Ciclopirox induces autophagy through reactive oxygen species-mediated activation of JNK signaling pathway .
17299004	0	Ciclosporin	0,11	paracellin-1	20,32	Ciclosporin	paracellin-1	MESH:D016572	114141(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|amod|END_ENTITY	Ciclosporin reduces paracellin-1 expression and magnesium transport in thick ascending limb cells .
11948417	0	Cidofovir	16,25	p53	35,38	Cidofovir	p53	MESH:C059262	7157	Chemical	Gene	restores|nsubj|START_ENTITY restores|dobj|function function|compound|END_ENTITY	Antiviral agent Cidofovir restores p53 function and enhances the radiosensitivity in HPV-associated_cancers .
20596077	0	Ciglitazone	0,11	CXCL1	33,38	Ciglitazone	CXCL1	MESH:C039671	2919	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Ciglitazone negatively regulates CXCL1 signaling through MITF to suppress melanoma growth .
16171799	0	Ciglitazone	0,11	PPARgamma	82,91	Ciglitazone	PPARgamma	MESH:C039671	25664(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|nmod|END_ENTITY	Ciglitazone inhibits the antigen-induced leukotrienes production independently of PPARgamma in RBL-2H3 mast cells .
16844232	0	Ciglitazone	132,143	PPARgamma	0,9	Ciglitazone	PPARgamma	MESH:C039671	19016(Tax:10090)	Chemical	Gene	reverse|nmod|START_ENTITY reverse|nsubj|antagonists antagonists|compound|END_ENTITY	PPARgamma antagonists reverse the inhibition of neural antigen-specific Th1 response and experimental_allergic_encephalomyelitis by Ciglitazone and 15-deoxy-Delta12 ,14 - prostaglandin_J2 .
18780770	0	Ciglitazone	0,11	PPARgamma	15,24	Ciglitazone	PPARgamma	MESH:C039671	19016(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Ciglitazone , a PPARgamma agonist , ameliorates diabetic_nephropathy in part through homocysteine clearance .
17940898	0	Ciglitazone	0,11	XIAP	77,81	Ciglitazone	XIAP	MESH:C039671	331	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|down-regulation down-regulation|nmod|END_ENTITY	Ciglitazone induces caspase-independent apoptosis through down-regulation of XIAP and survivin in human glioma cells .
17494862	0	Ciglitazone	0,11	peroxisome_proliferator-activated_receptor_gamma	15,63	Ciglitazone	peroxisome proliferator-activated receptor gamma	MESH:C039671	25664(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inducer inducer|amod|END_ENTITY	Ciglitazone , a peroxisome_proliferator-activated_receptor_gamma inducer , ameliorates renal preglomerular production and activity of angiotensin_II and thromboxane_A2 in glycerol-induced acute_renal_failure .
18097565	0	Ciglitazone	0,11	peroxisome_proliferator-activated_receptor_gamma	27,75	Ciglitazone	peroxisome proliferator-activated receptor gamma	MESH:C039671	5468	Chemical	Gene	START_ENTITY|appos|agonist agonist|nmod|END_ENTITY	Ciglitazone , an agonist of peroxisome_proliferator-activated_receptor_gamma , exerts potentiated cytostatic/cytotoxic effects against tumor cells when combined with lovastatin .
25593646	0	Ciglitazone	0,11	peroxisome_proliferator-activated_receptor_gamma	15,63	Ciglitazone	peroxisome proliferator-activated receptor gamma	MESH:C039671	5468	Chemical	Gene	START_ENTITY|appos|ligand ligand|amod|END_ENTITY	Ciglitazone , a peroxisome_proliferator-activated_receptor_gamma ligand , inhibits proliferation and differentiation of th17 cells .
11108164	0	Cilazapril	172,182	ACE	157,160	Cilazapril	ACE	MESH:D017315	1636	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Evaluation of coronary blood flow reserve by 13N-NH3 positron emission computed tomography -LRB- PET -RRB- with dipyridamole in the treatment of hypertension with the ACE inhibitor -LRB- Cilazapril -RRB- .
2532461	0	Cilazapril	0,10	angiotensin-converting_enzyme	39,68	Cilazapril	angiotensin-converting enzyme	MESH:D017315	1636	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Cilazapril : a new non-thiol-containing angiotensin-converting_enzyme inhibitor .
16985092	0	Cilomilast	0,10	phosphodiesterase-4	36,55	Cilomilast	phosphodiesterase-4	MESH:C433247	5141	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Cilomilast : orally active selective phosphodiesterase-4 inhibitor for treatment of chronic_obstructive_pulmonary_disease .
26514426	0	Cilostazol	0,10	ADAM17	42,48	Cilostazol	ADAM17	MESH:C045645	6868	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Cilostazol inhibits interleukin-1-induced ADAM17 expression through cAMP independent signaling in vascular smooth muscle cells .
19885004	0	Cilostazol	0,10	CD36	48,52	Cilostazol	CD36	MESH:C045645	12491(Tax:10090)	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Cilostazol Attenuates 4-hydroxynonenal-enhanced CD36 Expression on Murine Macrophages via Inhibition of NADPH Oxidase-derived Reactive Oxygen Species Production .
19543489	0	Cilostazol	0,10	ERK1/2	91,97	Cilostazol	ERK1/2	MESH:C045645	5595;5594	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|END_ENTITY	Cilostazol protects endothelial cells against lipopolysaccharide-induced apoptosis through ERK1/2 - and P38 MAPK-dependent pathways .
26181635	0	Cilostazol	0,10	Epac-1	68,74	Cilostazol	Epac-1	MESH:C045645	10411	Chemical	Gene	Production|compound|START_ENTITY Production|nmod|END_ENTITY	Cilostazol Induces PGI2 Production via Activation of the Downstream Epac-1 / Rap1 Signaling Cascade to Increase Intracellular Calcium by PLC and to Activate p44/42 MAPK in Human Aortic Endothelial Cells .
21994478	0	Cilostazol	0,10	Heme_Oxygenase-1	163,179	Cilostazol	Heme Oxygenase-1	MESH:C045645	3162	Chemical	Gene	Proliferation|compound|START_ENTITY Species|nsubj|Proliferation Species|nmod|END_ENTITY	Cilostazol Inhibits Vascular Smooth Muscle Cell Proliferation and Reactive Oxygen Species Production through Activation of AMP-activated_Protein_Kinase Induced by Heme_Oxygenase-1 .
17516547	0	Cilostazol	0,10	MCP-1	22,27	Cilostazol	MCP-1	MESH:C045645	100009130(Tax:9986)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|amod|END_ENTITY	Cilostazol attenuates MCP-1 and MMP-9 expression in vivo in LPS-administrated balloon-injured rabbit aorta and in vitro in LPS-treated monocytic THP-1 cells .
15464320	0	Cilostazol	0,10	Mac-1	39,44	Cilostazol	Mac-1	MESH:C045645	3684	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Cilostazol inhibits leukocyte integrin Mac-1 , leading to a potential reduction in restenosis after coronary stent implantation .
19513289	0	Cilostazol	0,10	PAC-1	19,24	Cilostazol	PAC-1	MESH:C045645	1844	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|compound|END_ENTITY	Cilostazol reduces PAC-1 expression on platelets in ischemic_stroke .
22563259	0	Cilostazol	0,10	TNFalpha	38,46	Cilostazol	TNFalpha	MESH:C045645	21926(Tax:10090)	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Cilostazol Decreases Ethanol-Mediated TNFalpha Expression in RAW264 .7 Murine Macrophage and in Liver from Binge Drinking Mice .
24458133	0	Cilostazol	0,10	sterol_regulatory_binding_protein-1c	53,89	Cilostazol	sterol regulatory binding protein-1c	MESH:C045645	6720	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Cilostazol inhibits insulin-stimulated expression of sterol_regulatory_binding_protein-1c via inhibition of LXR and Sp1 .
21327325	0	Cimetidine	0,10	E-selectin	146,156	Cimetidine	E-selectin	MESH:D002927	6401	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|adhesion adhesion|nmod|cells cells|acl|expressing expressing|advcl|blocking blocking|dobj|expression expression|amod|END_ENTITY	Cimetidine inhibits the adhesion of gastric_cancer cells expressing high levels of sialyl Lewis x in human vascular endothelial cells by blocking E-selectin expression .
24879290	0	Cimetidine	0,10	E-selectin	74,84	Cimetidine	E-selectin	MESH:D002927	20339(Tax:10090)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|advcl|militating militating|dobj|expression expression|amod|END_ENTITY	Cimetidine attenuates vinorelbine-induced phlebitis in mice by militating E-selectin expression .
7268211	0	Cimetidine	0,10	aryl_hydrocarbon_hydroxylase	44,72	Cimetidine	aryl hydrocarbon hydroxylase	MESH:D002927	24296(Tax:10116)	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	Cimetidine : a specific inhibitor of hepatic aryl_hydrocarbon_hydroxylase -LRB- AHH -RRB- in the rat .
6133739	0	Cimetidine	0,10	gastrin	28,35	Cimetidine	gastrin	MESH:D002927	2520	Chemical	Gene	blocks|nsubj|START_ENTITY blocks|dobj|activation activation|nmod:poss|END_ENTITY	Cimetidine partially blocks gastrin 's activation of gastric mucosal guanylate cyclase .
7843262	0	Cimetidine	0,10	gastrin	77,84	Cimetidine	gastrin	MESH:D002927	25320(Tax:10116)	Chemical	Gene	START_ENTITY|dep|accelerate accelerate|nmod|increase increase|nmod|secretion secretion|compound|END_ENTITY	Cimetidine and omeprazole accelerate gastric ulcer_healing by an increase in gastrin secretion .
11742570	0	Cimetidine	0,10	interferon_gamma	34,50	Cimetidine	interferon gamma	MESH:D002927	15978(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|nmod|END_ENTITY	Cimetidine inhibits production of interferon_gamma and tumor_necrosis_factor_alpha by splenocytes in aplastic_anemic mice .
3261818	0	Cimetidine	0,10	interleukin-2	46,59	Cimetidine	interleukin-2	MESH:D002927	16183(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|inhibition inhibition|nmod|production production|compound|END_ENTITY	Cimetidine reduces cyclosporine inhibition of interleukin-2 production .
3497460	2	Cimetidine	60,70	interleukin-2	95,108	Cimetidine	interleukin-2	MESH:D002927	16183(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|production production|compound|END_ENTITY	Cimetidine and ranitidine increase interleukin-2 production .
447203	0	Cimetidine	0,10	prolactin	22,31	Cimetidine	prolactin	MESH:D002927	5617	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	Cimetidine effects on prolactin release and production .
7132728	0	Cimetidine	0,10	prolactin	48,57	Cimetidine	prolactin	MESH:D002927	5617	Chemical	Gene	effect|amod|START_ENTITY effect|nmod|modulation modulation|nmod|END_ENTITY	Cimetidine effect of dopaminergic modulation of prolactin release in healthy women .
25605129	0	Cinnamaldehyde	47,61	Ghrelin	74,81	Cinnamaldehyde	Ghrelin	MESH:C012843	58991(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|Secretion Secretion|compound|END_ENTITY	Anti-Obesity and Anti-Hyperglycemic Effects of Cinnamaldehyde via altered Ghrelin Secretion and Functional impact on Food Intake and Gastric Emptying .
24719730	0	Cinnamaldehyde	60,74	Glucose_Transporter_4	14,35	Cinnamaldehyde	Glucose Transporter 4	MESH:C012843	20528(Tax:10090)	Chemical	Gene	Increased|nmod|START_ENTITY Increased|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of Glucose_Transporter_4 -LRB- GLUT4 -RRB- is Increased by Cinnamaldehyde in C2C12 Mouse Muscle Cells .
16624280	0	Cinnamaldehyde	0,14	cyclooxygenase-2	40,56	Cinnamaldehyde	cyclooxygenase-2	MESH:C012843	29527(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|activity activity|amod|END_ENTITY	Cinnamaldehyde reduces IL-1beta-induced cyclooxygenase-2 activity in rat cerebral microvascular endothelial cells .
22803375	0	Cinnamaldehyde	1,15	interleukin-1beta	26,43	Cinnamaldehyde	interleukin-1beta	MESH:C012843	16176(Tax:10090)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|production production|amod|END_ENTITY	-LSB- Cinnamaldehyde decreases interleukin-1beta induced PGE2 production by down-regulation of mPGES-1 and COX-2 expression in mouse macrophage RAW264 .7 cells -RSB- .
10969976	0	Cinnamaldehydes	0,15	cyclin_D1	50,59	Cinnamaldehydes	cyclin D1	CHEBI:23245	595	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|END_ENTITY	Cinnamaldehydes inhibit cyclin_dependent_kinase_4 / cyclin_D1 .
15225701	0	Cinnamic_acid_esters	0,20	17beta-hydroxysteroid_dehydrogenase	52,87	Cinnamic acid esters	17beta-hydroxysteroid dehydrogenase	null	345275	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Cinnamic_acid_esters as potent inhibitors of fungal 17beta-hydroxysteroid_dehydrogenase -- a model enzyme of the short-chain dehydrogenase/reductase superfamily .
19571431	0	Ciprofloxacin	0,13	Cyp3a	25,30	Ciprofloxacin	Cyp3a	MESH:D002939	13112(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	Ciprofloxacin suppresses Cyp3a in mouse liver by reducing lithocholic_acid-producing intestinal flora .
21572514	0	Ciprofloxacin	3,16	P-glycoprotein	32,46	Ciprofloxacin	P-glycoprotein	MESH:D002939	5243	Chemical	Gene	Substrate|nsubj|START_ENTITY Substrate|nmod|END_ENTITY	Is Ciprofloxacin a Substrate of P-glycoprotein ?
24001138	0	Ciprofloxacin	0,13	helicase	56,64	Ciprofloxacin	helicase	MESH:D002939	164045	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Ciprofloxacin is an inhibitor of the Mcm2-7 replicative helicase .
12428247	0	Ciprofloxacin	0,13	interleukin-1beta	83,100	Ciprofloxacin	interleukin-1beta	MESH:D002939	3553	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Ciprofloxacin enhances the stimulation of matrix metalloproteinase 3 expression by interleukin-1beta in human tendon-derived cells .
25612651	0	Cisplatin	14,23	APRIL	0,5	Cisplatin	APRIL	MESH:D002945	8741	Chemical	Gene	Resistance|compound|START_ENTITY Resistance|compound|END_ENTITY	APRIL Induces Cisplatin Resistance in Gastric_Cancer Cells via Activation of the NF-kB Pathway .
17016665	0	Cisplatin	70,79	Akt	17,20	Cisplatin	Akt	MESH:D002945	207	Chemical	Gene	efficacy|nmod|START_ENTITY antagonize|dobj|efficacy LY294005|xcomp|antagonize LY294005|nsubj|Potential Potential|nmod|inhibitor inhibitor|compound|END_ENTITY	Potential of the Akt inhibitor LY294005 to antagonize the efficacy of Cisplatin against HCT116_tumor cells in a DNA mismatch repair-dependent manner .
21074548	0	Cisplatin	0,9	Akt	72,75	Cisplatin	Akt	MESH:D002945	11651(Tax:10090)	Chemical	Gene	triggers|nsubj|START_ENTITY triggers|dobj|atrophy_of_skeletal_C2C12_myotubes atrophy_of_skeletal_C2C12_myotubes|nmod|impairment impairment|nmod|END_ENTITY	Cisplatin triggers atrophy_of_skeletal_C2C12_myotubes via impairment of Akt signalling pathway and subsequent increment activity of proteasome and autophagy systems .
21482801	0	Cisplatin	0,9	Atox1	39,44	Cisplatin	Atox1	MESH:D002945	475	Chemical	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Cisplatin binds human copper chaperone Atox1 and promotes unfolding in vitro .
23708917	0	Cisplatin	0,9	BCL2L12	24,31	Cisplatin	BCL2L12	MESH:D002945	83596	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	Cisplatin downregulates BCL2L12 , a novel apoptosis-related gene , in glioblastoma cells .
22084573	0	Cisplatin	33,42	BRCA1	51,56	Cisplatin	BRCA1	MESH:D002945	672	Chemical	Gene	START_ENTITY|nmod|Protein Protein|compound|END_ENTITY	In Vitro Enhanced Sensitivity to Cisplatin in D67Y BRCA1 RING Domain Protein .
24709421	0	Cisplatin	0,9	Bmi-1	18,23	Cisplatin	Bmi-1	MESH:D002945	648	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Cisplatin induces Bmi-1 and enhances the stem cell fraction in head_and_neck_cancer .
24200080	0	Cisplatin	29,38	Cyclophilin_A	0,13	Cisplatin	Cyclophilin A	MESH:D002945	5478	Chemical	Gene	target|nmod|START_ENTITY END_ENTITY|nmod|target	Cyclophilin_A as a target of Cisplatin chemosensitizers .
24935589	0	Cisplatin	0,9	E-cadherin	120,130	Cisplatin	E-cadherin	MESH:D002945	999	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|regulating regulating|dobj|END_ENTITY	Cisplatin combined with metformin inhibits migration and invasion of human nasopharyngeal_carcinoma cells by regulating E-cadherin and MMP-9 .
9722577	0	Cisplatin	0,9	ERCC-1	23,29	Cisplatin	ERCC-1	MESH:D002945	2067	Chemical	Gene	induction|compound|START_ENTITY induction|nmod|expression expression|compound|END_ENTITY	Cisplatin induction of ERCC-1 mRNA expression in A2780/CP70 human ovarian_cancer cells .
20719134	0	Cisplatin	76,85	ERCC1	26,31	Cisplatin	ERCC1	MESH:D002945	2067	Chemical	Gene	Chemotherapy|compound|START_ENTITY Cancer|nmod|Chemotherapy Trend|nmod|Cancer Effects|nmod|Trend Effects|nmod|RRM1 RRM1|compound|END_ENTITY	-LSB- Effects of Expression of ERCC1 , RRM1 on Survival Trend of Lung Cancer with Cisplatin Combine Gemcitabine Chemotherapy after Surgical Resection . -RSB- .
21996734	0	Cisplatin	0,9	ERCC1	94,99	Cisplatin	ERCC1	MESH:D002945	2067	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|induce induce|dobj|expression expression|nmod|END_ENTITY	Cisplatin regulates the MAPK kinase pathway to induce increased expression of DNA repair gene ERCC1 and increase melanoma chemoresistance .
17516123	0	Cisplatin	0,9	ERK	108,111	Cisplatin	ERK	MESH:D002945	24338(Tax:10116)	Chemical	Gene	cytotoxicity|compound|START_ENTITY requires|nsubj|cytotoxicity requires|dobj|secretions secretions|nmod|cytokines cytokines|nmod|activation activation|nmod|END_ENTITY	Cisplatin cytotoxicity of auditory cells requires secretions of proinflammatory cytokines via activation of ERK and NF-kappaB .
22445428	0	Cisplatin	0,9	ERK	49,52	Cisplatin	ERK	MESH:D002945	5594	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Cisplatin induces platelet_apoptosis through the ERK signaling pathway .
26065336	0	Cisplatin	82,91	ERK	129,132	Cisplatin	ERK	MESH:D002945	5594	Chemical	Gene	Cells|nmod|START_ENTITY Sensitizes|dobj|Cells Sensitizes|nmod|Inhibition Inhibition|nmod|Pathway Pathway|compound|END_ENTITY	NBM-T-BMX-OS01 , an Osthole Derivative , Sensitizes Human Lung Cancer A549 Cells to Cisplatin through AMPK-Dependent Inhibition of ERK and Akt Pathway .
20937224	0	Cisplatin	0,9	Erk	95,98	Cisplatin	Erk	MESH:D002945	5594	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|over-expression over-expression|nmod|cells cells|nmod|MAPK MAPK|compound|END_ENTITY	Cisplatin induces programmed_death-1-ligand_1 -LRB- PD-L1 -RRB- over-expression in hepatoma H22 cells via Erk / MAPK signaling pathway .
18271937	0	Cisplatin	0,9	ICAM-1	23,29	Cisplatin	ICAM-1	MESH:D002945	3383	Chemical	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|compound|END_ENTITY	Cisplatin up-regulates ICAM-1 expression in endothelial cell via a NF-kappaB dependent pathway .
9484843	0	Cisplatin	0,9	JNK	45,48	Cisplatin	JNK	MESH:D002945	5599	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|nmod|END_ENTITY	Cisplatin induces a persistent activation of JNK that is related to cell death .
25253429	0	Cisplatin	138,147	MDR1	0,4	Cisplatin	MDR1	MESH:D002945	5243	Chemical	Gene	Treated|nmod|START_ENTITY Chemosensitivity|nmod|Treated Markers|nmod|Chemosensitivity Markers|compound|END_ENTITY	MDR1 and Cytochrome_P450 Gene-Expression Profiles as Markers of Chemosensitivity in Human Chronic_Myelogenous_Leukemia Cells Treated with Cisplatin and Ru -LRB- III -RRB- Metallocomplexes .
25939760	0	Cisplatin	25,34	MEK	0,3	Cisplatin	MEK	MESH:D002945	5609	Chemical	Gene	Resistance|compound|START_ENTITY Resistance|compound|END_ENTITY	MEK Inhibition Overcomes Cisplatin Resistance Conferred by SOS/MAPK Pathway Activation in Squamous_Cell_Carcinoma .
26155939	0	Cisplatin	0,9	MEK1/2	19,25	Cisplatin	MEK1/2	MESH:D002945	5604;5605	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Cisplatin inhibits MEK1/2 .
27051056	0	Cisplatin	51,60	MG132	21,26	Cisplatin	MG132	MESH:D002945	875581(Tax:243273)	Chemical	Gene	Sensitivity|nmod|START_ENTITY Sensitivity|compound|END_ENTITY	Proteasome Inhibitor MG132 Enhances Sensitivity to Cisplatin on Ovarian_Carcinoma Cells In Vitro and In Vivo .
23340649	0	Cisplatin	96,105	MMP-2	71,76	Cisplatin	MMP-2	MESH:D002945	4313	Chemical	Gene	Cytotoxicity|compound|START_ENTITY Inhibitor|acl|Cytotoxicity Inhibitor|compound|END_ENTITY	Pre-Treatment of Platinum Resistant Ovarian_Cancer Cells with an MMP-9 / MMP-2 Inhibitor Prior to Cisplatin Enhances Cytotoxicity as Determined by High Content Screening .
23485110	0	Cisplatin	0,9	MSH2	22,26	Cisplatin	MSH2	MESH:D002945	4436	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	Cisplatin upregulates MSH2 expression by reducing miR-21 to inhibit A549 cell growth .
26491674	0	Cisplatin	21,30	Osteopontin	0,11	Cisplatin	Osteopontin	MESH:D002945	6696	Chemical	Gene	Resistance|compound|START_ENTITY Resistance|compound|END_ENTITY	Osteopontin Involves Cisplatin Resistance and Poor Prognosis in Oral_Squamous_Cell_Carcinoma .
26431211	0	Cisplatin	19,28	P53	0,3	Cisplatin	P53	MESH:D002945	7157	Chemical	Gene	Renal_Oxidative_Damage|compound|START_ENTITY Contributes|nmod|Renal_Oxidative_Damage Contributes|nsubj|END_ENTITY	P53 Contributes to Cisplatin Induced Renal_Oxidative_Damage via Regulating P66shc and MnSOD .
26903157	0	Cisplatin	85,94	SIRT1	1,6	Cisplatin	SIRT1	MESH:D002945	23411	Chemical	Gene	Line|nmod|START_ENTITY Sensitivity|nmod|Line Influences|dobj|Sensitivity Influences|nsubj|END_ENTITY	-LSB- SIRT1 Influences the Sensitivity of A549 Non-small_Cell_Lung_Cancer Cell Line to Cisplatin via Modulating the Noxa Expression -RSB- .
21416250	0	Cisplatin	0,9	Sirt1	18,23	Cisplatin	Sirt1	MESH:D002945	23411	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Cisplatin induces Sirt1 in association with histone deacetylation and increased Werner_syndrome_protein in the kidney .
21152876	0	Cisplatin	0,9	TRAIL	110,115	Cisplatin	TRAIL	MESH:D002945	8743	Chemical	Gene	sensitizes|nsubj|START_ENTITY sensitizes|dobj|cells cells|acl|END_ENTITY	Cisplatin sensitizes human hepatocellular_carcinoma cells , but not hepatocytes and mesenchymal stem cells , to TRAIL within a therapeutic window partially depending on the upregulation of DR5 .
21877938	0	Cisplatin	0,9	TRAIL	19,24	Cisplatin	TRAIL	MESH:D002945	8743	Chemical	Gene	restores|nsubj|START_ENTITY restores|dobj|pathway pathway|amod|END_ENTITY	Cisplatin restores TRAIL apoptotic pathway in glioblastoma-derived stem cells through up-regulation of DR5 and down-regulation of c-FLIP .
1516581	0	Cisplatin	0,9	VP16	41,45	Cisplatin	VP16	MESH:D002945	3054	Chemical	Gene	START_ENTITY|nmod|infusion infusion|compound|END_ENTITY	Cisplatin in combination with continuous VP16 infusion as second line chemotherapy in ovarian_carcinoma .
11287285	0	Cisplatin	0,9	X-chromosome-linked_inhibitor_of_apoptosis_protein	37,87	Cisplatin	X-chromosome-linked inhibitor of apoptosis protein	MESH:D002945	331	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Cisplatin inhibits the expression of X-chromosome-linked_inhibitor_of_apoptosis_protein in an oral_carcinoma cell line .
15610860	0	Cisplatin	0,9	X-linked_inhibitor_of_apoptosis_protein	37,76	Cisplatin	X-linked inhibitor of apoptosis protein	MESH:D002945	331	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Cisplatin inhibits the expression of X-linked_inhibitor_of_apoptosis_protein in human LNCaP cells .
25211326	0	Cisplatin	55,64	b-Catenin	36,45	Cisplatin	b-Catenin	MESH:D002945	1499	Chemical	Gene	Resistance|compound|START_ENTITY Resistance|amod|END_ENTITY	Interference with the Expression of b-Catenin Reverses Cisplatin Resistance in A2780/DDP Cells and Inhibits the Progression of Ovarian_Cancer in Mouse Model .
2234901	0	Cisplatin	0,9	epidermal_growth_factor	18,41	Cisplatin	epidermal growth factor	MESH:D002945	1950	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|receptors receptors|compound|END_ENTITY	Cisplatin reduces epidermal_growth_factor receptors in squamous-cell_carcinoma in vitro .
16638873	0	Cisplatin	84,93	erythropoietin	21,35	Cisplatin	erythropoietin	MESH:D002945	24335(Tax:10116)	Chemical	Gene	peripheral_neurotoxicity|amod|START_ENTITY effect|nmod|peripheral_neurotoxicity effect|nmod|END_ENTITY	Protective effect of erythropoietin and its carbamylated derivative in experimental Cisplatin peripheral_neurotoxicity .
16722547	0	Cisplatin	0,9	erythropoietin	32,46	Cisplatin	erythropoietin	MESH:D002945	2056	Chemical	Gene	chemotherapy|compound|START_ENTITY chemotherapy|nmod|END_ENTITY	Cisplatin chemotherapy -LRB- without erythropoietin -RRB- and risk of life-threatening thromboembolic_events in carcinoma_of_the_uterine_cervix : the tip of the iceberg ?
12928720	0	Cisplatin	0,9	frataxin	21,29	Cisplatin	frataxin	MESH:D002945	2395	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|compound|END_ENTITY	Cisplatin may induce frataxin expression .
8765241	0	Cisplatin	0,9	gamma-glutamyl_transpeptidase	40,69	Cisplatin	gamma-glutamyl transpeptidase	MESH:D002945	116568(Tax:10116)	Chemical	Gene	nephrotoxicity|compound|START_ENTITY nephrotoxicity|parataxis|blocks blocks|nsubj|inhibition inhibition|nmod|END_ENTITY	Cisplatin nephrotoxicity : inhibition of gamma-glutamyl_transpeptidase blocks the nephrotoxicity of cisplatin without reducing platinum concentrations in the kidney .
15475465	0	Cisplatin	0,9	hCTR1	60,65	Cisplatin	hCTR1	MESH:D002945	1317	Chemical	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|END_ENTITY	Cisplatin rapidly down-regulates its own influx transporter hCTR1 in cultured human ovarian_carcinoma cells .
1930221	0	Cisplatin	0,9	hsp25	47,52	Cisplatin	hsp25	MESH:D002945	3315	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|protein protein|amod|END_ENTITY	Cisplatin induces the small heat_shock protein hsp25 and thermotolerance in Ehrlich_ascites_tumor cells .
12528803	0	Cisplatin	0,9	mdr1	45,49	Cisplatin	mdr1	MESH:D002945	5243	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|transcription transcription|amod|END_ENTITY	Cisplatin , doxorubicin and paclitaxel induce mdr1 gene transcription in ovarian_cancer cell lines .
26564501	0	Cisplatin	16,25	miR-29b	0,7	Cisplatin	miR-29b	MESH:D002945	407024	Chemical	Gene	Resistance|compound|START_ENTITY Resistance|amod|END_ENTITY	miR-29b Reduces Cisplatin Resistance of Gastric_Cancer Cell by Targeting PI3K/Akt Pathway .
25556489	0	Cisplatin	17,26	miR-340	0,7	Cisplatin	miR-340	MESH:D002945	442908	Chemical	Gene	Resistance|compound|START_ENTITY Resistance|amod|END_ENTITY	miR-340 Reverses Cisplatin Resistance of Hepatocellular_Carcinoma Cell Lines by Targeting Nrf2-dependent Antioxidant Pathway .
26087719	0	Cisplatin	51,60	miR-93	69,75	Cisplatin	miR-93	MESH:D002945	407051	Chemical	Gene	START_ENTITY|nmod|Pathway Pathway|amod|END_ENTITY	Berberine Sensitizes Human Ovarian_Cancer Cells to Cisplatin Through miR-93 / PTEN/Akt Signaling Pathway .
16314463	0	Cisplatin	0,9	organic_cation_transporter_2	62,90	Cisplatin	organic cation transporter 2	MESH:D002945	6582	Chemical	Gene	mediated|nsubj|START_ENTITY mediated|nmod|END_ENTITY	Cisplatin nephrotoxicity is critically mediated via the human organic_cation_transporter_2 .
18559608	0	Cisplatin	15,24	organic_cation_transporter_2	40,68	Cisplatin	organic cation transporter 2	MESH:D002945	6582	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of Cisplatin with the human organic_cation_transporter_2 .
11477455	0	Cisplatin	0,9	p53	39,42	Cisplatin	p53	MESH:D002945	7157	Chemical	Gene	chemotherapy|compound|START_ENTITY chemotherapy|nmod|therapy therapy|compound|END_ENTITY	Cisplatin chemotherapy plus adenoviral p53 gene therapy in EBV-positive and - negative nasopharyngeal_carcinoma .
14991767	0	Cisplatin	0,9	p53	19,22	Cisplatin	p53	MESH:D002945	7157	Chemical	Gene	restores|nsubj|START_ENTITY restores|dobj|function function|compound|END_ENTITY	Cisplatin restores p53 function and enhances the radiosensitivity in HPV16 E6 containing SiHa cells .
18506185	0	Cisplatin	0,9	p53	92,95	Cisplatin	p53	MESH:D002945	7157	Chemical	Gene	alters|nsubj|START_ENTITY alters|parataxis|involvement involvement|nmod|regulation regulation|compound|END_ENTITY	Cisplatin alters nitric_oxide synthase levels in human ovarian_cancer cells : involvement in p53 regulation and cisplatin resistance .
19347880	0	Cisplatin	0,9	p53	87,90	Cisplatin	p53	MESH:D002945	7157	Chemical	Gene	resistance|compound|START_ENTITY conferred|nsubj|resistance conferred|ccomp|dependent dependent|nmod|status status|compound|END_ENTITY	Cisplatin resistance conferred by the RAD51D -LRB- E233G -RRB- genetic variant is dependent upon p53 status in human breast_carcinoma cell lines .
18248879	0	Cisplatin	0,9	transferrin	47,58	Cisplatin	transferrin	MESH:D002945	24825(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Cisplatin regulates Sertoli_cell expression of transferrin and interleukins .
20656057	0	Citral	0,6	PPARa	49,54	Citral	PPARa	MESH:C007076	5465	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Citral , a component of lemongrass oil , activates PPARa and y and suppresses COX-2 expression .
27069776	0	Citrate	33,40	NaCT	79,83	Citrate	NaCT	C102006	284111	Chemical	Gene	Flux|compound|START_ENTITY Assessment|nmod|Flux Assessment|dep|Implications Implications|nmod|END_ENTITY	Model-Based Assessment of Plasma Citrate Flux Into the Liver : Implications for NaCT as a Therapeutic Target .
17725555	0	Citrate	0,7	lupin	29,34	Citrate	lupin	MESH:D019343	51251	Chemical	Gene	exudation|amod|START_ENTITY exudation|nmod|END_ENTITY	Citrate exudation from white lupin induced by phosphorus_deficiency differs from that induced by aluminum .
2497449	0	Citrate	0,7	tyrosinase	18,28	Citrate	tyrosinase	MESH:D019343	22173(Tax:10090)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Citrate activates tyrosinase from B-16 murine melanoma and human skin .
26731665	0	Citreohybridonol	20,36	Cytochrome_P450	0,15	Citreohybridonol	Cytochrome P450	null	4051	Chemical	Gene	Synthesis|compound|START_ENTITY END_ENTITY|nmod|Synthesis	Cytochrome_P450 for Citreohybridonol Synthesis : Oxidative Derivatization of the Andrastin Scaffold .
9870942	0	Citron	0,6	PSD-95	16,22	Citron	PSD-95	null	1742	Chemical	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Citron binds to PSD-95 at glutamatergic synapses on inhibitory neurons in the hippocampus .
23569086	0	Cl	44,46	Angiotensin_II	0,14	Cl	Angiotensin II	null	183	Chemical	Gene	channels|compound|START_ENTITY stimulates|dobj|channels stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates basolateral 10-pS Cl channels in the thick ascending limb .
3918456	0	Cl	22,24	Bradykinin	0,10	Cl	Bradykinin	null	3827	Chemical	Gene	secretion|compound|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Bradykinin stimulates Cl secretion and prostaglandin_E2 release by canine tracheal epithelium .
18550034	0	Cl	80,82	CA1	111,114	Cl	CA1	null	12346(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|region region|compound|END_ENTITY	Long-term expressional changes of Na + _ - K + _ - Cl - _ co-transporter_1 -LRB- NKCC1 -RRB- and K + _ - Cl - _ co-transporter_2 -LRB- KCC2 -RRB- in CA1 region of hippocampus following lithium-pilocarpine_induced_status_epilepticus -LRB- PISE -RRB- .
2260645	0	Cl	22,24	Ca2	1,4	Cl	Ca2	null	760	Chemical	Gene	modulation|nmod|START_ENTITY modulation|compound|END_ENTITY	-LSB- Ca2 + -RSB- i modulation of Cl - content controls cell volume in single salivary acinar cells during fluid secretion .
18077605	0	Cl	36,38	ClC-3	0,5	Cl	ClC-3	null	1182	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	ClC-3 is required for LPA-activated Cl - current activity and fibroblast-to-myofibroblast differentiation .
23720748	0	Cl	38,40	Epac1	4,9	Cl	Epac1	null	223864(Tax:10090)	Chemical	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	The Epac1 signaling pathway regulates Cl - secretion via modulation of apical KCNN4c channels in diarrhea .
22575459	0	Cl	62,64	Insulin-like_growth_factor-1	0,28	Cl	Insulin-like growth factor-1	null	24482(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY inhibits|dobj|channels inhibits|nsubj|END_ENTITY	Insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- inhibits the basolateral Cl channels in the thick ascending limb of the rat kidney .
1281891	0	Cl	40,42	Interleukin-2	0,13	Cl	Interleukin-2	null	3558	Chemical	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Interleukin-2 inhibits the GABA-induced Cl - current in identified Aplysia neurons .
10484331	0	Cl	53,55	Myosin	0,6	Cl	Myosin	null	79784	Chemical	Gene	effects|nmod|START_ENTITY regulation|dep|effects regulation|compound|END_ENTITY	Myosin regulation of NKCC1 : effects on cAMP-mediated Cl - secretion in intestinal epithelia .
9141359	0	Cl	101,103	P-glycoprotein	49,63	Cl	P-glycoprotein	null	5243	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Protein_kinase_C-independent correlation between P-glycoprotein expression and volume sensitivity of Cl - channel .
22392510	0	Cl	49,51	PdL2	68,72	Cl	PdL2	null	80380	Chemical	Gene	START_ENTITY|nmod|-RSB- -RSB-|compound|END_ENTITY	Halogen anion-induced formation of -LSB- -LRB- PdLX -RRB- 2 -RSB- -LRB- X = Cl - , Br - , _ I - -RRB- vs. -LSB- PdL2 -RSB- -LRB- L = -LSB- 6-MeO -LRB- O -RRB- CC6H4NHC -LRB- S -RRB- NP -LRB- S -RRB- -LRB- OiPr -RRB- 2 -RSB- - -RRB- : reversible photoinduced cis/trans isomerization of -LSB- PdL2 -RSB- .
18971389	0	Cl	54,56	Pendrin	0,7	Cl	Pendrin	null	23985(Tax:10090)	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Pendrin in the mouse kidney is primarily regulated by Cl - excretion but also by systemic metabolic_acidosis .
20207026	0	Cl	41,43	SGK1	17,21	Cl	SGK1	null	105930542	Chemical	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Arsenic inhibits SGK1 activation of CFTR Cl - channels in the gill of killifish , Fundulus_heteroclitus .
25542968	0	Cl	30,32	WNK4	14,18	Cl	WNK4	null	65266	Chemical	Gene	Effect|dep|START_ENTITY Effect|nmod|END_ENTITY	The Effect of WNK4 on the Na + - Cl - _ Cotransporter Is Modulated by Intracellular Chloride .
2849304	0	Cl	53,55	alpha_1	8,15	Cl	alpha 1	null	146	Chemical	Gene	receptors|nmod|START_ENTITY receptors|amod|END_ENTITY	Role of alpha_1 - and alpha 2-adrenergic receptors in Cl - transport across frog corneal epithelium .
11913465	0	Cl	123,125	cystic_fibrosis_transmembrane_conductance_regulator	14,65	Cl	cystic fibrosis transmembrane conductance regulator	null	1080	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of cystic_fibrosis_transmembrane_conductance_regulator in the skin of the toad , Bufo bufo and possible role for Cl - transport across the heterocellular epithelium .
15131065	0	Cl	82,84	cystic_fibrosis_transmembrane_conductance_regulator	17,68	Cl	cystic fibrosis transmembrane conductance regulator	null	1080	Chemical	Gene	inhibitor|nmod|START_ENTITY inhibitor|compound|END_ENTITY	Effects of a new cystic_fibrosis_transmembrane_conductance_regulator inhibitor on Cl - conductance in human sweat ducts .
9080465	1	Cl	338,340	neurotensin	361,372	Cl	neurotensin	null	67405(Tax:10090)	Chemical	Gene	START_ENTITY|dep|induced induced|nmod|END_ENTITY	The effect of the drug SR_48692 on the Ca -LRB- 2 + -RRB- - activated Cl - current induced by neurotensin on Xenopus oocytes injected with cRNAs encoding rodent high and low_affinity_neurotensin_receptors , was examined .
18658272	0	Cl	21,23	p38	93,96	Cl	p38	null	1432	Chemical	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Flagellin-stimulated Cl - secretion and innate immune responses in airway epithelia : role for p38 .
2475816	0	Cl	50,52	substance_P	14,25	Cl	substance P	null	6863	Chemical	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of substance_P and of a Ca2 + - activated Cl - current in quail sensory trigeminal neurons .
17718595	0	Cl	10,12	tyrosinase	17,27	Cl	tyrosinase	null	7299	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of Cl - on tyrosinase : complex inhibition kinetics and biochemical implication .
8301578	0	Cl-992	43,49	renin	27,32	Cl-992	renin	null	5972	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|inhibitor inhibitor|compound|END_ENTITY	Effect of an orally active renin inhibitor Cl-992 on blood pressure in normotensive and hypertensive monkeys .
15742438	4	Cl-IB-MECA	597,607	A3AR	583,587	Cl-IB-MECA	A3AR	MESH:C107562	11542(Tax:10090)	Chemical	Gene	effect|appos|START_ENTITY effect|nmod|agonist agonist|compound|END_ENTITY	The clinical effect of another A3AR agonist , Cl-IB-MECA , was examined in rat AIA .
21354814	0	Cl-IB-MECA	0,10	TNF-a	20,25	Cl-IB-MECA	TNF-a	MESH:C107562	7124	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|release release|amod|END_ENTITY	Cl-IB-MECA enhances TNF-a release in peritoneal macrophages stimulated with LPS .
19088383	0	ClC	96,99	Ste20	73,78	ClC	Ste20	null	8428	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Identification of regulatory phosphorylation sites in a cell volume - and Ste20 kinase-dependent ClC anion channel .
23408874	0	ClC-1_chloride	26,40	CLCN1	68,73	ClC-1 chloride	CLCN1	null	1180	Chemical	Gene	channels|compound|START_ENTITY channels|nmod|END_ENTITY	Novel brain expression of ClC-1_chloride channels and enrichment of CLCN1 variants in epilepsy .
22613974	0	ClC-2	18,23	JAK2	27,31	ClC-2	JAK2	null	443637(Tax:8355)	Chemical	Gene	Downregulation|nmod|START_ENTITY Downregulation|nmod|END_ENTITY	Downregulation of ClC-2 by JAK2 .
10662728	0	ClC-5_chloride	28,42	PTH	0,3	ClC-5 chloride	PTH	null	24694(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY expression|nmod|channel regulates|dobj|expression regulates|nsubj|END_ENTITY	PTH regulates expression of ClC-5_chloride channel in the kidney .
6328960	0	Claforan	24,32	CTX	34,37	Claforan	CTX	MESH:D002439	1593	Chemical	Gene	evaluation|nmod|START_ENTITY evaluation|appos|END_ENTITY	-LSB- Clinical evaluation of Claforan -LRB- CTX -RRB- in aged patients with chronic complicated urinary tract infections -RSB- .
25623533	0	Claramine	25,34	PTP1B	44,49	Claramine	PTP1B	null	19246(Tax:10090)	Chemical	Gene	properties|nmod|START_ENTITY properties|dep|inhibitor inhibitor|compound|END_ENTITY	Functional properties of Claramine : a novel PTP1B inhibitor and insulin-mimetic compound .
19897389	0	Clarithromycin	0,14	CYP3A	38,43	Clarithromycin	CYP3A	MESH:D017291	1576	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Clarithromycin , a potent inhibitor of CYP3A , greatly increases exposure to oral S-ketamine .
20446912	0	Clarithromycin	60,74	CYP3A	100,105	Clarithromycin	CYP3A	MESH:D017291	1576	Chemical	Gene	Inhibition|nmod|START_ENTITY Assessment|nmod|Inhibition Assessment|dep|Use Use|nmod|Domperidone Domperidone|nmod|Substrate Substrate|compound|END_ENTITY	Assessment of Competitive and Mechanism-Based Inhibition by Clarithromycin : Use of Domperidone as a CYP3A Probe-Drug Substrate and Various Enzymatic Sources Including a New Cell-Based Assay with Freshly Isolated Human Hepatocytes .
26190895	0	Clarithromycin	10,24	UL16-Binding_Protein_2	46,68	Clarithromycin	UL16-Binding Protein 2	MESH:D017291	80328	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of Clarithromycin on the Expression of UL16-Binding_Protein_2 in Human Cells .
21665488	0	Clarithromycin	0,14	interleukin-10	43,57	Clarithromycin	interleukin-10	MESH:D017291	25325(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Clarithromycin and telithromycin increases interleukin-10 expression in the rat endometriosis model .
20653035	0	Clathrin	0,8	AP180	27,32	Clathrin	AP180	null	65178(Tax:10116)	Chemical	Gene	proteins|amod|START_ENTITY proteins|dep|END_ENTITY	Clathrin assembly proteins AP180 and CALM in the embryonic rat brain .
11577110	0	Clathrin	0,8	HIP1	36,40	Clathrin	HIP1	null	3092	Chemical	Gene	sites|amod|START_ENTITY sites|nmod|END_ENTITY	Clathrin - and AP-2-binding sites in HIP1 uncover a general assembly role for endocytic accessory proteins .
25140002	0	Clemizole_hydrochloride	0,23	TRPC5	96,101	Clemizole hydrochloride	TRPC5	null	7224	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Clemizole_hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5 .
17669268	0	Clenbuterol	0,11	CREB1	55,60	Clenbuterol	CREB1	MESH:D002976	1385	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|activating activating|dobj|END_ENTITY	Clenbuterol inhibits SREBP-1c expression by activating CREB1 .
22071161	0	Clenbuterol	0,11	PGC-1_alpha	58,69	Clenbuterol	PGC-1 alpha	MESH:D002976	83516(Tax:10116)	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|END_ENTITY	Clenbuterol , a b2-adrenergic agonist , reciprocally alters PGC-1_alpha and RIP140 and reduces fatty_acid and pyruvate oxidation in rat skeletal muscle .
17669268	0	Clenbuterol	0,11	SREBP-1c	21,29	Clenbuterol	SREBP-1c	MESH:D002976	6720	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Clenbuterol inhibits SREBP-1c expression by activating CREB1 .
2447978	0	Clenbuterol	0,11	a_beta	13,19	Clenbuterol	a beta	MESH:D002976	54226(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Clenbuterol , a_beta agonist , induces growth in innervated and denervated rat soleus muscle via apparently different mechanisms .
9142894	0	Clenbuterol	0,11	beta2-adrenoceptor	15,33	Clenbuterol	beta2-adrenoceptor	MESH:D002976	24176(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Clenbuterol , a beta2-adrenoceptor agonist , reduces scoliosis due to partial transection of rat spinal cord .
9176197	0	Clenbuterol	0,11	myogenin	40,48	Clenbuterol	myogenin	MESH:D002976	29148(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Clenbuterol increases the expression of myogenin but not myoD in immobilized rat muscles .
24646654	0	Clioquinol	0,10	VGF	39,42	Clioquinol	VGF	MESH:D007464	7425	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Clioquinol increases the expression of VGF , a neuropeptide precursor , through induction of c-Fos expression .
21868515	0	Clioquinol	0,10	cyclin_D1	22,31	Clioquinol	cyclin D1	MESH:D007464	595	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Clioquinol suppresses cyclin_D1 gene expression through transcriptional and post-transcriptional mechanisms .
22076618	0	Clobetasol	0,10	SLPI	26,30	Clobetasol	SLPI	MESH:D002990	6590	Chemical	Gene	down-regulates|amod|START_ENTITY END_ENTITY|nsubj|down-regulates	Clobetasol down-regulates SLPI expression in U937 monocytoid cells .
8139381	0	Clodronate	0,10	IL-6	70,74	Clodronate	IL-6	MESH:D004002	16193(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Clodronate -LRB- dichloromethylene_bisphosphonate -RRB- inhibits LPS-stimulated IL-6 and TNF production by RAW 264 cells .
22691880	0	Clofibrate	0,10	PPARa	11,16	Clofibrate	PPARa	MESH:D002994	25747(Tax:10116)	Chemical	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Clofibrate PPARa activation reduces oxidative stress and improves ultrastructure and ventricular hemodynamics in no-flow myocardial_ischemia .
24247298	0	Clofibrate	0,10	heme_oxygenase_1	19,35	Clofibrate	heme oxygenase 1	MESH:D002994	3162	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Clofibrate induces heme_oxygenase_1 expression through a PPARa-independent mechanism in human cancer cells .
10660093	0	Clofilium	0,9	caspase-3	140,149	Clofilium	caspase-3	MESH:C022799	836	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|apoptosis apoptosis|nmod|cells cells|nmod|activation activation|nmod|END_ENTITY	Clofilium , a potassium channel blocker , induces apoptosis of human promyelocytic_leukemia -LRB- HL-60 -RRB- cells via Bcl-2-insensitive activation of caspase-3 .
24392395	0	Clomiphene	54,64	Prolactin	113,122	Clomiphene	Prolactin	MESH:D002996	5617	Chemical	Gene	START_ENTITY|nmod|Bromocriptine Bromocriptine|nmod|Patients Patients|nmod|END_ENTITY	Induction of Ovulation with Clomiphene_Citrate Versus Clomiphene with Bromocriptine in PCOS Patients with Normal Prolactin : A Comparative Study .
24392395	0	Clomiphene_Citrate	28,46	Prolactin	113,122	Clomiphene Citrate	Prolactin	MESH:D002996	5617	Chemical	Gene	Clomiphene|compound|START_ENTITY Clomiphene|nmod|Bromocriptine Bromocriptine|nmod|Patients Patients|nmod|END_ENTITY	Induction of Ovulation with Clomiphene_Citrate Versus Clomiphene with Bromocriptine in PCOS Patients with Normal Prolactin : A Comparative Study .
7750589	0	Clomiphene_citrate	0,18	insulin-like_growth_factor_I	33,61	Clomiphene citrate	insulin-like growth factor I	MESH:D002996	3479	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|iobj|END_ENTITY	Clomiphene_citrate reduces serum insulin-like_growth_factor_I and increases sex_hormone-binding_globulin levels in women with polycystic_ovary_syndrome .
7750589	0	Clomiphene_citrate	0,18	sex_hormone-binding_globulin	76,104	Clomiphene citrate	sex hormone-binding globulin	MESH:D002996	6462	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|levels levels|amod|END_ENTITY	Clomiphene_citrate reduces serum insulin-like_growth_factor_I and increases sex_hormone-binding_globulin levels in women with polycystic_ovary_syndrome .
7529711	0	Clomipramine	0,12	cholecystokinin	37,52	Clomipramine	cholecystokinin	MESH:D002997	25298(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|levels levels|compound|END_ENTITY	Clomipramine and clonazepam increase cholecystokinin levels in rat ventral tegmental area and limbic regions .
3016787	0	Clomipramine	0,12	prolactin	22,31	Clomipramine	prolactin	MESH:D002997	5617	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|responses responses|compound|END_ENTITY	Clomipramine enhances prolactin and growth_hormone responses to L-tryptophan .
2856643	0	Clonidine	0,9	ANF	48,51	Clonidine	ANF	MESH:D003000	24602(Tax:10116)	Chemical	Gene	atrial_natriuretic_factor|amod|START_ENTITY atrial_natriuretic_factor|appos|END_ENTITY	Clonidine stimulates atrial_natriuretic_factor -LRB- ANF -RRB- release in water-deprived rats .
11530748	0	Clonidine	1,10	CO2	95,98	Clonidine	CO2	MESH:D003000	717	Chemical	Gene	combined|nsubj|START_ENTITY combined|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Clonidine combined with flunitrazepam before carotid endarterectomy decreases cerebrovascular CO2 reactivity -RSB- .
7477880	0	Clonidine	0,9	Fos	55,58	Clonidine	Fos	MESH:D003000	100338345(Tax:9986)	Chemical	Gene	START_ENTITY|dobj|expression expression|compound|END_ENTITY	Clonidine and rilmenidine suppress hypotension-induced Fos expression in the lower brainstem of the conscious rabbit .
7901787	0	Clonidine	0,9	GH	42,44	Clonidine	GH	MESH:D003000	81668(Tax:10116)	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|response response|appos|END_ENTITY	Clonidine potentiates the growth_hormone -LRB- GH -RRB- response to GH-releasing hormone in norepinephrine synthesis-inhibited rats : evidence for an alpha-2-adrenergic control of hypothalamic release of somatostatin .
7938032	1	Clonidine	533,542	GH	610,612	Clonidine	GH	MESH:D003000	2688	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|dobj|release release|compound|END_ENTITY	Clonidine and BRO -LRB- 10 -LRB- -6 -RRB- M -RRB- inhibited basal and GHRH -LRB- 10 -LRB- -10 -RRB- M -RRB- - stimulated GH release .
20368793	0	Clonidine	73,82	Growth_Hormone	99,113	Clonidine	Growth Hormone	MESH:D003000	2688	Chemical	Gene	Provocation|compound|START_ENTITY Provocation|nmod|Testing Testing|compound|END_ENTITY	Respiratory_Depression in Young Prader_Willi_Syndrome Patients following Clonidine Provocation for Growth_Hormone Secretion Testing .
26361394	0	Clonidine	9,18	Growth_Hormone	128,142	Clonidine	Growth Hormone	MESH:D003000	2688	Chemical	Gene	Testing|compound|START_ENTITY Reveals|nsubj|Testing Reveals|nmod|Deficiency Deficiency|compound|END_ENTITY	Modified Clonidine Testing for Growth_Hormone Stimulation Reveals a2-Adrenoreceptor Sub Sensitivity in Children with Idiopathic Growth_Hormone Deficiency .
26361394	0	Clonidine	9,18	Growth_Hormone	31,45	Clonidine	Growth Hormone	MESH:D003000	2688	Chemical	Gene	Testing|compound|START_ENTITY Testing|nmod|Stimulation Stimulation|compound|END_ENTITY	Modified Clonidine Testing for Growth_Hormone Stimulation Reveals a2-Adrenoreceptor Sub Sensitivity in Children with Idiopathic Growth_Hormone Deficiency .
26485273	0	Clonidine	21,30	Growth_Hormone	140,154	Clonidine	Growth Hormone	MESH:D003000	2688	Chemical	Gene	Testing|compound|START_ENTITY Reveals|nsubj|Testing Reveals|nmod|Deficiency Deficiency|compound|END_ENTITY	Correction : Modified Clonidine Testing for Growth_Hormone Stimulation Reveals a2-Adrenoreceptor Sub Sensitivity in Children with Idiopathic Growth_Hormone Deficiency .
26485273	0	Clonidine	21,30	Growth_Hormone	43,57	Clonidine	Growth Hormone	MESH:D003000	2688	Chemical	Gene	Testing|compound|START_ENTITY Testing|nmod|Stimulation Stimulation|compound|END_ENTITY	Correction : Modified Clonidine Testing for Growth_Hormone Stimulation Reveals a2-Adrenoreceptor Sub Sensitivity in Children with Idiopathic Growth_Hormone Deficiency .
2525782	0	Clonidine	0,9	atrial_natriuretic_peptide	32,58	Clonidine	atrial natriuretic peptide	MESH:D003000	24602(Tax:10116)	Chemical	Gene	increase|amod|START_ENTITY END_ENTITY|nsubj|increase	Clonidine and morphine increase atrial_natriuretic_peptide secretion in anesthetized rats .
19520131	0	Clonidine	0,9	calcitonin_gene-related_peptide	18,49	Clonidine	calcitonin gene-related peptide	MESH:D003000	796	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Clonidine induces calcitonin_gene-related_peptide expression via nitric_oxide pathway in endothelial cells .
23888314	0	Clonidine	0,9	growth_hormone	47,61	Clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	stimulation|amod|START_ENTITY stimulation|nmod|secretion secretion|compound|END_ENTITY	Clonidine and glucagon stimulation for testing growth_hormone secretion in children and adolescents : can we make it with fewer samples ?
2861413	0	Clonidine	0,9	growth_hormone	55,69	Clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	accelerates|nsubj|START_ENTITY accelerates|nmod|children children|nmod|secretion secretion|compound|END_ENTITY	Clonidine accelerates growth in children with impaired growth_hormone secretion .
2951760	0	Clonidine	0,9	growth_hormone	43,57	Clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	stimulation|amod|START_ENTITY stimulation|dep|END_ENTITY	Clonidine stimulation in anorexia_nervosa : growth_hormone , cortisol , and beta-endorphin responses .
6684063	0	Clonidine	0,9	growth_hormone	47,61	Clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	START_ENTITY|nmod|stimulus stimulus|nmod|secretion secretion|amod|END_ENTITY	Clonidine -LRB- Haemiton -RRB- as a reliable stimulus of growth_hormone secretion in patients with short_stature .
7283239	0	Clonidine	0,9	growth_hormone	47,61	Clonidine	growth hormone	MESH:D003000	403795(Tax:9615)	Chemical	Gene	START_ENTITY|nmod|tests tests|nmod|secretion secretion|amod|END_ENTITY	Clonidine or xylazine as provocative tests for growth_hormone secretion in the dog .
7617133	0	Clonidine	0,9	growth_hormone	26,40	Clonidine	growth hormone	MESH:D003000	81668(Tax:10116)	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|response response|amod|END_ENTITY	Clonidine potentiates the growth_hormone response to a growth_hormone_releasing_hormone challenge in hypothalamic growth_hormone_releasing_hormone deficient rats .
7901787	0	Clonidine	0,9	growth_hormone	26,40	Clonidine	growth hormone	MESH:D003000	81668(Tax:10116)	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|response response|compound|END_ENTITY	Clonidine potentiates the growth_hormone -LRB- GH -RRB- response to GH-releasing hormone in norepinephrine synthesis-inhibited rats : evidence for an alpha-2-adrenergic control of hypothalamic release of somatostatin .
6337026	0	Clonidine	0,9	renin	49,54	Clonidine	renin	MESH:D003000	5972	Chemical	Gene	lowers|nsubj|START_ENTITY lowers|dobj|pressure pressure|nmod|suppression suppression|compound|END_ENTITY	Clonidine lowers blood pressure independently of renin suppression in patients with unilateral renal_artery_stenosis .
6400111	0	Clonidine	0,9	renin	127,132	Clonidine	renin	MESH:D003000	5972	Chemical	Gene	START_ENTITY|dep|antihypertensive antihypertensive|nmod|effects effects|compound|END_ENTITY	Clonidine in unilateral_renal_artery_stenosis and unilateral renal_parenchymal_disease -- similar antihypertensive but different renin suppressive effects .
19398604	0	Clopidogrel	0,11	CYP2C19	78,85	Clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|hydroxylation hydroxylation|nmod|omeprazole omeprazole|acl|related related|nmod|polymorphisms polymorphisms|nummod|END_ENTITY	Clopidogrel inhibits CYP2C19-dependent hydroxylation of omeprazole related to CYP2C19 genetic polymorphisms .
21215696	0	Clopidogrel	0,11	CYP2C19	40,47	Clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	Resistance|amod|START_ENTITY Resistance|dep|reports reports|nmod|variants variants|nummod|END_ENTITY	Clopidogrel Resistance : case reports of CYP2C19 gene variants in suspected coronary stent thrombosis .
23333143	0	Clopidogrel	0,11	CYP2C19	109,116	Clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	pharmacokinetics|amod|START_ENTITY vary|nsubj|pharmacokinetics vary|nmod|exclusion exclusion|nmod|polymorphisms polymorphisms|appos|END_ENTITY	Clopidogrel pharmacokinetics and pharmacodynamics vary widely despite exclusion or control of polymorphisms -LRB- CYP2C19 , ABCB1 , PON1 -RRB- , noncompliance , diet , smoking , co-medications -LRB- including proton pump inhibitors -RRB- , and pre-existent variability in platelet function .
23431496	0	Clopidogrel	62,73	CYP2C19	4,11	Clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	Response|compound|START_ENTITY Does|dobj|Response Does|nsubj|END_ENTITY	The CYP2C19 -LRB- -RRB- 1 / -LRB- -RRB- 2 Genotype Does Not Adequately Predict Clopidogrel Response in Healthy Malaysian Volunteers .
24402637	0	Clopidogrel	0,11	CYP2C19	54,61	Clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	status|amod|START_ENTITY based|nsubj|status based|nmod|testing testing|compound|END_ENTITY	Clopidogrel metaboliser status based on point-of-care CYP2C19 genetic testing in patients with coronary_artery_disease .
24956245	0	Clopidogrel	0,11	CYP2C19	59,66	Clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	adjustment|amod|START_ENTITY adjustment|nmod|screening screening|nmod|alleles alleles|compound|END_ENTITY	Clopidogrel dose adjustment after outpatient screening for CYP2C19 variant alleles : a pilot study .
25311974	0	Clopidogrel	27,38	CYP2C19	114,121	Clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|function function|nmod|subjects subjects|nmod|genotype genotype|compound|END_ENTITY	Non-antiplatelet effect of Clopidogrel : Improving endothelial function in Chinese healthy subjects with different CYP2C19 genotype .
25529343	0	Clopidogrel	86,97	CYP2C19	0,7	Clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	Treated|nmod|START_ENTITY Recurrence|nmod|Treated Recurrence|nsubj|Genotype Genotype|compound|END_ENTITY	CYP2C19 Genotype and Early Ischemic Lesion Recurrence in Stroke Patients Treated with Clopidogrel .
25609219	0	Clopidogrel	116,127	CYP2C19	84,91	Clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	Polymorphism|nmod|START_ENTITY Polymorphism|compound|END_ENTITY	Physiologically Based Pharmacokinetic Modeling for Sequential Metabolism : Effect of CYP2C19 Genetic Polymorphism on Clopidogrel and Clopidogrel Active Metabolite Pharmacokinetics .
25628978	0	Clopidogrel	76,87	CYP2C19	22,29	Clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	Treated|nmod|START_ENTITY Patients|acl|Treated Polymorphisms|nmod|Patients Polymorphisms|compound|END_ENTITY	Routine Screening for CYP2C19 Polymorphisms for Patients being Treated with Clopidogrel is not Recommended .
25937796	0	Clopidogrel	86,97	CYP2C19	11,18	Clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	Using|dobj|START_ENTITY Polymorphisms|advcl|Using Polymorphisms|nsubj|Effects Effects|nmod|Gene Gene|compound|END_ENTITY	Effects of CYP2C19 and P2Y12 Gene Polymorphisms on Clinical Results of Patients Using Clopidogrel after Acute Ischemic_Cerebrovascular_Disease .
26063503	0	Clopidogrel	90,101	CYP2C19	121,128	Clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	Study|nmod|START_ENTITY Study|nmod|Groups Groups|compound|END_ENTITY	A Randomized Study of the Safety , Tolerability , Pharmacodynamics , and Pharmacokinetics of Clopidogrel in Three Different CYP2C19 Genotype Groups of Healthy Japanese Subjects .
26177117	0	Clopidogrel	140,151	CYP2C19	120,127	Clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	Response|compound|START_ENTITY Genotype|nmod|Response Genotype|compound|END_ENTITY	Influence of Genetic Polymorphisms on Clopidogrel Response and Clinical Outcomes in Patients with Acute Ischemic Stroke CYP2C19 Genotype on Clopidogrel Response .
26177117	0	Clopidogrel	38,49	CYP2C19	120,127	Clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	Response|compound|START_ENTITY Polymorphisms|nmod|Response Influence|nmod|Polymorphisms Influence|nmod|Genotype Genotype|compound|END_ENTITY	Influence of Genetic Polymorphisms on Clopidogrel Response and Clinical Outcomes in Patients with Acute Ischemic Stroke CYP2C19 Genotype on Clopidogrel Response .
26218263	0	Clopidogrel	79,90	CYP2C19	107,114	Clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	Genotyping|compound|START_ENTITY Genotyping|compound|END_ENTITY	Implementation of Cell Samples as Controls in National Proficiency Testing for Clopidogrel Therapy-Related CYP2C19 Genotyping in China : A Novel Approach .
26265611	0	Clopidogrel	68,79	CYP2C19	0,7	Clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	Tested|compound|START_ENTITY *|nmod|Tested *|nsubj|END_ENTITY	CYP2C19 * 2 and Other Allelic Variants Affecting Platelet Response to Clopidogrel Tested by Thrombelastography in Patients with Acute_Coronary_Syndrome .
26526111	0	Clopidogrel	129,140	CYP2C19	10,17	Clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|Effect Effect|nmod|Polymorphisms Polymorphisms|compound|END_ENTITY	Effect of CYP2C19 Polymorphisms on the Platelet Response to Clopidogrel and Influence on the Effect of High Versus Standard Dose Clopidogrel in Carotid Artery Stenting .
26526111	0	Clopidogrel	60,71	CYP2C19	10,17	Clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|Polymorphisms Polymorphisms|compound|END_ENTITY	Effect of CYP2C19 Polymorphisms on the Platelet Response to Clopidogrel and Influence on the Effect of High Versus Standard Dose Clopidogrel in Carotid Artery Stenting .
26916483	0	Clopidogrel	89,100	CYP2C19	10,17	Clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	Treated|nmod|START_ENTITY Impact|nmod|Treated Impact|nmod|Status Status|compound|END_ENTITY	Impact of CYP2C19 Metabolizer Status on Patients With ACS Treated With Prasugrel Versus Clopidogrel .
14563790	5	Clopidogrel	592,603	CYP2C9	619,625	Clopidogrel	CYP2B6	MESH:C055162	1555	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|dobj|END_ENTITY	Clopidogrel also inhibited CYP2C9 , and ticlopidine also inhibited CYP1A2 , with lower potency .
26891871	0	Clopidogrel	80,91	CYP3A4	10,16	Clopidogrel	CYP3A4	MESH:C055162	1576	Chemical	Gene	Pharmacokinetics|nmod|START_ENTITY Allele|nmod|Pharmacokinetics Impact|dep|Allele Impact|nmod|END_ENTITY	Impact of CYP3A4 * 1G Allele on Clinical Pharmacokinetics and Pharmacodynamics of Clopidogrel .
25836953	0	Clopidogrel	108,119	Fibrinogen	12,22	Clopidogrel	Fibrinogen	MESH:C055162	2244	Chemical	Gene	Efficacy|nmod|START_ENTITY Efficacy|nmod|Concentrate Concentrate|compound|END_ENTITY	Efficacy of Fibrinogen Concentrate Compared With Cryoprecipitate for Reversal of the Antiplatelet Effect of Clopidogrel in an In Vitro Model , as Assessed by Multiple Electrode Platelet Aggregometry , Thromboelastometry , and Modified Thromboelastography .
12621388	0	Clopidogrel	0,11	P-selectin	36,46	Clopidogrel	P-selectin	MESH:C055162	6403	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|amod|END_ENTITY	Clopidogrel but not aspirin reduces P-selectin expression and formation of platelet-leukocyte aggregates in patients with atherosclerotic_vascular_disease .
22721490	0	Clopidogrel	0,11	P2Y1	131,135	Clopidogrel	P2Y1	MESH:C055162	5028	Chemical	Gene	resistance|amod|START_ENTITY resistance|nmod|END_ENTITY	Clopidogrel resistance in North Indian patients of coronary_artery_disease and lack of its association with platelet ADP receptors P2Y1 and P2Y12 gene polymorphisms .
16835302	0	Clopidogrel	25,36	P2Y12	46,51	Clopidogrel	P2Y12	MESH:C055162	64805	Chemical	Gene	metabolite|nmod|START_ENTITY disrupts|nsubj|metabolite disrupts|dobj|oligomers oligomers|nummod|END_ENTITY	The active metabolite of Clopidogrel disrupts P2Y12 receptor oligomers and partitions them out of lipid rafts .
19811450	0	Clopidogrel	0,11	P2Y12	37,42	Clopidogrel	P2Y12	MESH:C055162	64803(Tax:10116)	Chemical	Gene	START_ENTITY|appos|independent independent|nmod|receptor receptor|compound|END_ENTITY	Clopidogrel , independent of vascular P2Y12 receptor , improves the arterial function in small mesenteric arteries from Ang_II-hypertensive rats .
19943165	0	Clopidogrel	0,11	P2Y12	64,69	Clopidogrel	P2Y12	MESH:C055162	64805	Chemical	Gene	affects|nsubj|START_ENTITY affects|advcl|expressing expressing|nsubj|END_ENTITY	Clopidogrel affects leukocyte dependent platelet_aggregation by P2Y12 expressing leukocytes .
21467700	0	Clopidogrel	0,11	P2Y12	144,149	Clopidogrel	P2Y12	MESH:C055162	64805	Chemical	Gene	resistance|amod|START_ENTITY cilostazol|nsubj|resistance cilostazol|nmod|patients patients|nmod|artery artery|acl|stenting stenting|advcl|using using|dobj|Assay Assay|compound|END_ENTITY	Clopidogrel resistance and the effect of combination cilostazol in patients with ischemic_stroke or carotid artery stenting using the VerifyNow P2Y12 Assay .
22028806	0	Clopidogrel	0,11	P2Y12	15,20	Clopidogrel	P2Y12	MESH:C055162	64803(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Clopidogrel , a P2Y12 receptor antagonist , potentiates the inflammatory response in a rat model of peptidoglycan polysaccharide-induced arthritis .
23826440	0	Clopidogrel	0,11	P2Y12	26,31	Clopidogrel	P2Y12	MESH:C055162	64805	Chemical	Gene	Resistance|amod|START_ENTITY Resistance|nmod|Testing Testing|compound|END_ENTITY	Clopidogrel Resistance by P2Y12 Platelet Function Testing in Patients Undergoing Neuroendovascular Procedures : Incidence of Ischemic_and_Hemorrhagic_Complications .
25064920	0	Clopidogrel	97,108	P2Y12	56,61	Clopidogrel	P2Y12	MESH:C055162	64805	Chemical	Gene	Administered|compound|START_ENTITY Tailor|dobj|Administered Using|xcomp|Tailor Using|dobj|Range Range|compound|END_ENTITY	O-007 Initial Institutional Experience Using a Target P2Y12 Reaction Units Range to Tailor the Clopidogrel Dose Administered to Patients with Cerebral_Aneurysms Treated with the Pipeline Embolization Device and Stents .
26119655	0	Clopidogrel	92,103	P2Y12	46,51	Clopidogrel	P2Y12	MESH:C055162	64805	Chemical	Gene	Meta-Analysis|nmod|START_ENTITY Meta-Analysis|nmod|Comparison Comparison|nmod|Inhibitors Inhibitors|compound|END_ENTITY	Meta-Analysis of Comparison of the Newer Oral P2Y12 Inhibitors -LRB- Prasugrel or Ticagrelor -RRB- to Clopidogrel in Patients With Non-ST-Elevation Acute Coronary_Syndrome .
26294943	0	Clopidogrel	47,58	P2Y12	70,75	Clopidogrel	P2Y12	MESH:C055162	64805	Chemical	Gene	Inhibition|compound|START_ENTITY Inhibition|compound|END_ENTITY	Omega-3_Fatty_Acid_Ethyl_Esters do not Improve Clopidogrel Associated P2Y12 Inhibition in Stroke Patients .
26553698	0	Clopidogrel	103,114	P2Y12	83,88	Clopidogrel	P2Y12	MESH:C055162	64805	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|compound|END_ENTITY	Efficacy of Ex Vivo Autologous and In Vivo Platelet Transfusion in the Reversal of P2Y12 Inhibition by Clopidogrel , Prasugrel , and Ticagrelor : The APTITUDE Study .
19026985	0	Cloretazine	75,86	DNA_polymerase_beta	20,39	Cloretazine	DNA polymerase beta	MESH:C483604	5423	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activity activity|compound|END_ENTITY	Inhibition of human DNA_polymerase_beta activity by the anticancer prodrug Cloretazine .
8219005	0	Cloricromene	0,12	phospholipase_A2	55,71	Cloricromene	phospholipase A2	MESH:C025945	151056	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	Cloricromene inhibits G-protein-mediated activation of phospholipase_A2 in human platelets .
11343695	0	Cloricromene	0,12	tumor_necrosis_factor-alpha	61,88	Cloricromene	tumor necrosis factor-alpha	MESH:C025945	24835(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Cloricromene , a semi-synthetic coumarin derivative , inhibits tumor_necrosis_factor-alpha production at a pre-transcriptional level .
20346906	0	Clotrimazole	0,12	6-phosphofructo-1-kinase	84,108	Clotrimazole	6-phosphofructo-1-kinase	MESH:D003022	5213	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|nmod|END_ENTITY	Clotrimazole potentiates the inhibitory effects of ATP on the key glycolytic enzyme 6-phosphofructo-1-kinase .
3100941	0	Clotrimazole	0,12	cytochrome_P-450	26,42	Clotrimazole	cytochrome P-450	MESH:D003022	25251(Tax:10116)	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Clotrimazole induction of cytochrome_P-450 : dose-differentiated isozyme induction .
1426017	0	Clozapine	0,9	5-HT1A	42,48	Clozapine	5-HT1A	MESH:D003024	3350	Chemical	Gene	has|nsubj|START_ENTITY has|dobj|affinity affinity|nmod|receptors receptors|nummod|END_ENTITY	Clozapine has sub-micromolar affinity for 5-HT1A receptors in human brain tissue .
20412811	0	Clozapine	0,9	5-HT1A	27,33	Clozapine	5-HT1A	MESH:D003024	15550(Tax:10090)	Chemical	Gene	require|nsubj|START_ENTITY require|dobj|receptors receptors|nummod|END_ENTITY	Clozapine does not require 5-HT1A receptors to block the locomotor hyperactivity induced by MK-801 Clz and MK-801 in KO1A mice .
7957629	0	Clozapine	0,9	5-HT1A	92,98	Clozapine	5-HT1A	MESH:D003024	24473(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|action action|nmod|receptors receptors|amod|1-adrenoceptors 1-adrenoceptors|nmod|END_ENTITY	Clozapine inhibits serotoninergic transmission by an action at alpha 1-adrenoceptors not at 5-HT1A receptors .
9456005	0	Clozapine	0,9	5-HT1A	61,67	Clozapine	5-HT1A	MESH:D003024	24473(Tax:10116)	Chemical	Gene	increases|amod|START_ENTITY dopamine|nsubj|increases dopamine|nmod|activation activation|nummod|END_ENTITY	Clozapine increases dopamine release in prefrontal cortex by 5-HT1A receptor activation .
16542821	0	Clozapine	0,9	Akt	41,44	Clozapine	Akt	MESH:D003024	207	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Clozapine , a neuroleptic agent , inhibits Akt by counteracting Ca2 + / calmodulin in PTEN-negative U-87MG human glioblastoma cells .
22934219	0	Clozapine	49,58	CRP	42,45	Clozapine	CRP	MESH:D003024	1401	Chemical	Gene	Toxicity|compound|START_ENTITY END_ENTITY|nmod|Toxicity	The Value of Desmethylclozapine and Serum CRP in Clozapine Toxicity : A Case Report .
15739191	0	Clozapine	0,9	GLT-1	18,23	Clozapine	GLT-1	MESH:D003024	6506	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|compound|END_ENTITY	Clozapine reduces GLT-1 expression and glutamate uptake in astrocyte cultures .
11158250	0	Clozapine	0,9	apolipoprotein_D	20,36	Clozapine	apolipoprotein D	MESH:D003024	11815(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Clozapine increases apolipoprotein_D expression in rodent brain : towards a mechanism for neuroleptic pharmacotherapy .
17011169	0	Clozapine	0,9	apolipoprotein_D	75,91	Clozapine	apolipoprotein D	MESH:D003024	11815(Tax:10090)	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|pathway pathway|nmod|mice mice|acl|lacking lacking|xcomp|END_ENTITY	Clozapine specifically alters the arachidonic_acid pathway in mice lacking apolipoprotein_D .
20083089	0	Clozapine	19,28	apolipoprotein_D	47,63	Clozapine	apolipoprotein D	MESH:D003024	25239(Tax:10116)	Chemical	Gene	administration|amod|START_ENTITY administration|nmod|levels levels|amod|END_ENTITY	Effects of chronic Clozapine administration on apolipoprotein_D levels and on functional recovery following experimental stroke .
7901792	0	Clozapine	0,9	dopamine_D3_receptor	36,56	Clozapine	dopamine D3 receptor	MESH:D003024	29238(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|levels levels|amod|END_ENTITY	Clozapine and sulpiride up-regulate dopamine_D3_receptor mRNA levels .
23142770	0	Clozapine	0,9	p90RSK	24,30	Clozapine	p90RSK	MESH:D003024	20112(Tax:10090)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Clozapine regulation of p90RSK and c-Fos signaling via the ErbB1-ERK pathway is distinct from olanzapine and haloperidol in mouse cortex and striatum .
26286430	0	Cnidium_Lactone	10,25	P53	42,45	Cnidium Lactone	P53	null	7157	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of Cnidium_Lactone on Serum Mutant P53 and BCL-2 / BAX Expression in Human Prostate_Cancer Cells PC-3 Tumor-Bearing BALB/C Nude Mouse Model .
16305240	0	Co-C	0,4	Co2	96,99	Co-C	Co2	CHEBI:28887	717	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Co-C bond activation in methylmalonyl-CoA_mutase by stabilization of the post-homolysis product Co2 + cobalamin .
15358145	0	Co-chaperone	0,12	CHIP	13,17	Co-chaperone	CHIP	null	358	Chemical	Gene	associates|amod|START_ENTITY associates|compound|END_ENTITY	Co-chaperone CHIP associates with mutant Cu/Zn-superoxide dismutase proteins linked to familial_amyotrophic_lateral_sclerosis and promotes their degradation by proteasomes .
751223	0	Co-trimoxazole	0,14	glucose-6-phosphate_dehydrogenase	66,99	Co-trimoxazole	glucose-6-phosphate dehydrogenase	MESH:D015662	2539	Chemical	Gene	START_ENTITY|nmod|children children|nmod|deficiency deficiency|amod|END_ENTITY	Co-trimoxazole in the treatment of typhoid_fever in children with glucose-6-phosphate_dehydrogenase deficiency .
7989334	0	CoA-esters	60,70	methylmalonyl-CoA_mutase	24,48	CoA-esters	methylmalonyl-CoA mutase	null	4594	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of the human methylmalonyl-CoA_mutase by various CoA-esters .
18289162	0	CoCl2	70,75	HIF-1_alpha	47,58	CoCl2	HIF-1 alpha	MESH:C018021	3091	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Melatonin modulates the expression of VEGF and HIF-1_alpha induced by CoCl2 in cultured cancer cells .
24945310	0	CoCl2	15,20	HIF-1a	24,30	CoCl2	HIF-1a	MESH:C018021	15251(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	The effects of CoCl2 on HIF-1a protein under experimental conditions of autoprogressive hypoxia using mouse models .
17629402	0	CoCl2	164,169	vasoactive_intestinal_contractor	114,146	CoCl2	vasoactive intestinal contractor	MESH:C018021	24324(Tax:10116)	Chemical	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	Characterization of CoCl2-induced reactive_oxygen_species -LRB- ROS -RRB- : Inductions of neurite outgrowth and endothelin-2 / vasoactive_intestinal_contractor in PC12 cells by CoCl2 are ROS dependent , but those by MnCl2 are not .
26179034	0	Coacervate	59,69	Sonic_Hedgehog	23,37	Coacervate	Sonic Hedgehog	null	6469	Chemical	Gene	Delivery|nmod|START_ENTITY Delivery|nmod|END_ENTITY	Controlled Delivery of Sonic_Hedgehog with a Heparin-Based Coacervate .
27057274	0	Cobalamin	53,62	Neuregulin_1	0,12	Cobalamin	Neuregulin 1	MESH:D014805	3084	Chemical	Gene	Metabolism|compound|START_ENTITY Metabolism|compound|END_ENTITY	Neuregulin_1 Promotes Glutathione-Dependent Neuronal Cobalamin Metabolism by Stimulating Cysteine Uptake .
12044973	0	Cobalamin	0,9	interleukin-6	47,60	Cobalamin	interleukin-6	MESH:D014805	24498(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|levels levels|amod|END_ENTITY	Cobalamin -LRB- vitamin_B -LRB- 12 -RRB- -RRB- positively regulates interleukin-6 levels in rat cerebrospinal fluid .
2556942	0	Cobalamin	0,9	intrinsic_factor	23,39	Cobalamin	intrinsic factor	MESH:D014805	29319(Tax:10116)	Chemical	Gene	release|nsubj|START_ENTITY release|nmod|END_ENTITY	Cobalamin release from intrinsic_factor and transfer to transcobalamin_II within the rat enterocyte .
2556942	0	Cobalamin	0,9	transcobalamin_II	56,73	Cobalamin	transcobalamin II	MESH:D014805	64365(Tax:10116)	Chemical	Gene	release|nsubj|START_ENTITY release|nmod|END_ENTITY	Cobalamin release from intrinsic_factor and transfer to transcobalamin_II within the rat enterocyte .
17015263	0	Cobalt	0,6	HIF-1alpha	48,58	Cobalt	HIF-1alpha	MESH:D003035	3091	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Cobalt induces hypoxia-inducible_factor-1alpha -LRB- HIF-1alpha -RRB- in HeLa cells by an iron-independent , but ROS - , PI-3K - _ and_MAPK-dependent mechanism .
7503328	0	Cobalt	0,6	erythropoietin	34,48	Cobalt	erythropoietin	MESH:D003035	24335(Tax:10116)	Chemical	Gene	exerts|nsubj|START_ENTITY exerts|nmod|expression expression|compound|END_ENTITY	Cobalt exerts opposite effects on erythropoietin gene expression in rat hepatocytes in vivo and in vitro .
11356853	0	Cobalt	0,6	heme_oxygenase-1	15,31	Cobalt	heme oxygenase-1	MESH:D003035	100756872	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Cobalt induces heme_oxygenase-1 expression by a hypoxia-inducible factor-independent mechanism in Chinese_hamster ovary cells : regulation by Nrf2 and MafG transcription factors .
19031313	0	Cobalt_chloride	0,15	EC-SOD	26,32	Cobalt chloride	EC-SOD	MESH:C018021	6649	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|amod|END_ENTITY	Cobalt_chloride decreases EC-SOD expression through intracellular ROS generation and p38-MAPK pathways in COS7 cells .
15284066	0	Cobalt_chloride	0,15	HIF-1alpha	96,106	Cobalt chloride	HIF-1alpha	MESH:C018021	15251(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Cobalt_chloride induces delayed cardiac preconditioning in mice through selective activation of HIF-1alpha and AP-1 and iNOS signaling .
24900196	0	Cobicistat	0,10	CYP3A	64,69	Cobicistat	CYP3A	MESH:C558922	1576	Chemical	Gene	START_ENTITY|dep|Inhibitor Inhibitor|nmod|END_ENTITY	Cobicistat -LRB- GS-9350 -RRB- : A Potent and Selective Inhibitor of Human CYP3A as a Novel Pharmacoenhancer .
25213649	0	Cocaine	0,7	5-HT2A	29,35	Cocaine	5-HT2A	MESH:D003042	29595(Tax:10116)	Chemical	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	Cocaine Potentiates Multiple 5-HT2A Receptor Signaling Pathways and Is Associated with Decreased Phosphorylation of 5-HT2A Receptors In Vivo .
7932162	0	Cocaine	0,7	ACTH	42,46	Cocaine	ACTH	MESH:D003042	5443	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|END_ENTITY	Cocaine effects on pulsatile secretion of ACTH in men .
21940433	0	Cocaine	0,7	BDNF	15,19	Cocaine	BDNF	MESH:D003042	12064(Tax:10090)	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|expression expression|compound|END_ENTITY	Cocaine alters BDNF expression and neuronal migration in the embryonic mouse forebrain .
25268928	0	Cocaine	0,7	BDNF	104,108	Cocaine	BDNF	MESH:D003042	627	Chemical	Gene	self-administration|amod|START_ENTITY causes|nsubj|self-administration causes|xcomp|signaling signaling|dobj|deficits deficits|acl:relcl|reversed reversed|nmod|END_ENTITY	Cocaine self-administration causes signaling deficits in corticostriatal circuitry that are reversed by BDNF in early withdrawal .
25734326	0	Cocaine	53,60	BDNF	25,29	Cocaine	BDNF	MESH:D003042	627	Chemical	Gene	Users|compound|START_ENTITY Concentrations|nmod|Users Concentrations|nmod|END_ENTITY	Plasma Concentrations of BDNF and IGF-1 in Abstinent Cocaine Users with High Prevalence of Substance Use Disorders : Relationship to Psychiatric Comorbidity .
12030814	0	Cocaine	0,7	CART	54,58	Cocaine	CART	MESH:D003042	29131(Tax:10116)	Chemical	Gene	peptide|compound|START_ENTITY peptide|dep|END_ENTITY	Cocaine and amphetamine-regulated transcript peptide -LRB- CART -LRB- 62-76 -RRB- -RRB- - induced changes in regional monoamine levels in ratbrain .
12600694	1	Cocaine	97,104	CART	144,148	Cocaine	CART	MESH:D003042	27220(Tax:10090)	Chemical	Gene	START_ENTITY|parataxis|involved involved|nsubjpass|peptide peptide|appos|END_ENTITY	Cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- peptide -LRB- CART - -LRB- 55-102 -RRB- -RRB- is involved in the suppression of food intake .
14729868	0	Cocaine	0,7	CART	47,51	Cocaine	CART	MESH:D003042	29131(Tax:10116)	Chemical	Gene	START_ENTITY|parataxis|expressed expressed|nsubjpass|and_amphetamine-regulated_transcript and_amphetamine-regulated_transcript|appos|END_ENTITY	Cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- is expressed in several islet cell types during rat development .
15051141	0	Cocaine	0,7	CART	55,59	Cocaine	CART	MESH:D003042	29131(Tax:10116)	Chemical	Gene	START_ENTITY|parataxis|marker marker|nsubj|peptide peptide|appos|END_ENTITY	Cocaine - _ and_amphetamine-regulated_transcript peptide -LRB- CART -RRB- is a selective marker of rat granule cells and of human mossy cells in the hippocampal dentate gyrus .
15380921	1	Cocaine	90,97	CART	137,141	Cocaine	CART	MESH:D003042	29131(Tax:10116)	Chemical	Gene	OBJECTIVE|dep|START_ENTITY OBJECTIVE|parataxis|neuropeptide neuropeptide|nsubj|and_amphetamine-regulated_transcript and_amphetamine-regulated_transcript|appos|END_ENTITY	OBJECTIVE : Cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- is a recently described neuropeptide widely expressed in the rat brain .
15874973	0	Cocaine	0,7	CART	47,51	Cocaine	CART	MESH:D003042	29131(Tax:10116)	Chemical	Gene	START_ENTITY|dep|_ _|dep|peptide peptide|appos|END_ENTITY	Cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- peptide : a vasoactive role in the cerebral circulation .
15908120	0	Cocaine	0,7	CART	47,51	Cocaine	CART	MESH:D003042	27220(Tax:10090)	Chemical	Gene	START_ENTITY|dep|and_amphetamine-regulated_transcript and_amphetamine-regulated_transcript|appos|END_ENTITY	Cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- peptide activates the extracellular signal-regulated kinase -LRB- ERK -RRB- pathway in AtT20 cells via putative G-protein coupled receptors .
16099925	0	Cocaine	0,7	CART	47,51	Cocaine	CART	MESH:D003042	27220(Tax:10090)	Chemical	Gene	START_ENTITY|dep|and_amphetamine-regulated_transcript and_amphetamine-regulated_transcript|appos|END_ENTITY	Cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- peptides modulate the locomotor and motivational properties of psychostimulants .
16621045	0	Cocaine	0,7	CART	75,79	Cocaine	CART	MESH:D003042	27220(Tax:10090)	Chemical	Gene	self-administration|amod|START_ENTITY altered|nsubjpass|self-administration altered|nmod|mice mice|amod|END_ENTITY	Cocaine self-administration and locomotor sensitization are not altered in CART knockout mice .
16774797	0	Cocaine	0,7	CART	45,49	Cocaine	CART	MESH:D003042	9607	Chemical	Gene	START_ENTITY|dep|and_amphetamine_related_transcript and_amphetamine_related_transcript|appos|END_ENTITY	Cocaine - _ and_amphetamine_related_transcript -LRB- CART -RRB- and anxiety .
17174283	0	Cocaine	0,7	CART	47,51	Cocaine	CART	MESH:D003042	29131(Tax:10116)	Chemical	Gene	START_ENTITY|dep|and_amphetamine-regulated_transcript and_amphetamine-regulated_transcript|appos|END_ENTITY	Cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- expression is differentially regulated in the hypothalamic paraventricular nucleus of lactating rats exposed to suckling or cold stimulation .
17292884	0	Cocaine	0,7	CART	47,51	Cocaine	CART	MESH:D003042	29131(Tax:10116)	Chemical	Gene	START_ENTITY|dep|PC12 PC12|appos|END_ENTITY	Cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- peptide specific binding in pheochromocytoma cells PC12 .
17525122	0	Cocaine	0,7	CART	47,51	Cocaine	CART	MESH:D003042	9607	Chemical	Gene	START_ENTITY|parataxis|colocalized colocalized|nsubjpass|and_amphetamine-regulated_transcript and_amphetamine-regulated_transcript|appos|END_ENTITY	Cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- is colocalized with the orexigenic neuropeptide Y and agouti-related_protein and absent from the anorexigenic alpha-melanocyte-stimulating_hormone neurons in the infundibular nucleus of the human hypothalamus .
17720743	0	Cocaine	0,7	CART	47,51	Cocaine	CART	MESH:D003042	9607	Chemical	Gene	START_ENTITY|parataxis|peptide peptide|nsubj|and_amphetamine-regulated_transcript and_amphetamine-regulated_transcript|appos|END_ENTITY	Cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- peptide as an in vivo regulator of cardiac function in Rana ridibunda frog .
17880396	0	Cocaine	0,7	CART	55,59	Cocaine	CART	MESH:D003042	29131(Tax:10116)	Chemical	Gene	peptide|amod|START_ENTITY peptide|appos|END_ENTITY	Cocaine - and amphetamine-regulated transcript peptide -LRB- CART -RRB- is present in peptidergic C primary afferents and axons of excitatory interneurons with a possible role in nociception in the superficial laminae of the rat spinal cord .
18314190	0	Cocaine	0,7	CART	49,53	Cocaine	CART	MESH:D003042	29131(Tax:10116)	Chemical	Gene	administration|amod|START_ENTITY increases|nsubj|administration increases|ccomp|accumbens accumbens|nsubj|fraction fraction|nmod|cells cells|amod|END_ENTITY	Cocaine administration increases the fraction of CART cells in the rat nucleus accumbens that co-immunostain for c-Fos .
18719668	1	Cocaine	92,99	CART	184,188	Cocaine	CART	MESH:D003042	29131(Tax:10116)	Chemical	Gene	OBJECTIVE|dep|START_ENTITY _|nsubj|OBJECTIVE _|nmod|neuropeptide neuropeptide|appos|END_ENTITY	OBJECTIVE : Cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- codes for a hypothalamic neuropeptide , CART -LRB- 55-102 -RRB- , which inhibits food intake .
19093718	0	Cocaine	65,72	CART	59,63	Cocaine	CART	MESH:D003042	27220(Tax:10090)	Chemical	Gene	peptide|dep|START_ENTITY peptide|compound|END_ENTITY	Anorexigenic effect of cholecystokinin is lost but that of CART -LRB- Cocaine and Amphetamine Regulated Transcript -RRB- peptide is preserved in monosodium_glutamate obese mice .
20528087	0	Cocaine	0,7	CART	44,48	Cocaine	CART	MESH:D003042	29131(Tax:10116)	Chemical	Gene	transcript|amod|START_ENTITY transcript|appos|END_ENTITY	Cocaine and amphetamine related transcript -LRB- CART -RRB- inhibits context induced reinstatement of reward seeking .
20595030	0	Cocaine	0,7	CART	47,51	Cocaine	CART	MESH:D003042	29131(Tax:10116)	Chemical	Gene	START_ENTITY|dep|receptors receptors|appos|END_ENTITY	Cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- peptide activates ERK pathways via NMDA receptors in rat spinal cord dorsal horn in an age-dependent manner .
20883668	0	Cocaine	0,7	CART	47,51	Cocaine	CART	MESH:D003042	29131(Tax:10116)	Chemical	Gene	START_ENTITY|dep|elements elements|appos|END_ENTITY	Cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- peptide-immunopositive neuronal elements in the lateral_septum : rostrocaudal distribution in the male rat .
20886038	0	Cocaine	0,7	CART	47,51	Cocaine	CART	MESH:D003042	29131(Tax:10116)	Chemical	Gene	START_ENTITY|parataxis|modulates modulates|nsubj|and_amphetamine-regulated_transcript and_amphetamine-regulated_transcript|appos|END_ENTITY	Cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- signaling within the paraventricular thalamus modulates cocaine-seeking behaviour .
21452197	0	Cocaine	0,7	CART	55,59	Cocaine	CART	MESH:D003042	9607	Chemical	Gene	START_ENTITY|dep|and_amphetamine-regulated_transcript_peptide and_amphetamine-regulated_transcript_peptide|appos|END_ENTITY	Cocaine - _ and_amphetamine-regulated_transcript_peptide -LRB- CART -RRB- in the telencephalon of the catfish , Clarias gariepinus : distribution and response to fasting , 2-deoxy-D-glucose , glucose , insulin , and leptin treatments .
23250745	0	Cocaine	0,7	CART	47,51	Cocaine	CART	MESH:D003042	29131(Tax:10116)	Chemical	Gene	START_ENTITY|parataxis|protects protects|nsubj|and_amphetamine-regulated_transcript and_amphetamine-regulated_transcript|appos|END_ENTITY	Cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- protects beta cells against glucotoxicity and increases cell proliferation .
23545074	0	Cocaine	0,7	CART	47,51	Cocaine	CART	MESH:D003042	29131(Tax:10116)	Chemical	Gene	START_ENTITY|parataxis|peptide peptide|nsubj|and_amphetamine-regulated_transcript and_amphetamine-regulated_transcript|appos|END_ENTITY	Cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- peptide immunoreactivity in feeding - and reward-related brain areas of young OLETF rats .
25729269	0	Cocaine	92,99	CART	63,67	Cocaine	CART	MESH:D003042	27220(Tax:10090)	Chemical	Gene	Administration|compound|START_ENTITY Peptides|nmod|Administration Peptides|nsubj|Involvement Involvement|nmod|Over-expression Over-expression|nmod|END_ENTITY	Predominant D1 Receptors Involvement in the Over-expression of CART Peptides after Repeated Cocaine Administration .
25992897	1	Cocaine	98,105	CART	254,258	Cocaine	CART	MESH:D003042	100858488	Chemical	Gene	UNASSIGNED|dep|START_ENTITY UNASSIGNED|parataxis|remains remains|nsubj|structure structure|nmod|gene gene|amod|END_ENTITY	UNASSIGNED : Cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- peptide is implicated in the control of avian energy balance , however , the structure and expression of CART gene -LRB- s -RRB- remains largely unknown in birds .
26009446	0	Cocaine	0,7	CART	47,51	Cocaine	CART	MESH:D003042	9607	Chemical	Gene	START_ENTITY|parataxis|upregulated upregulated|nsubjpass|and_amphetamine-regulated_transcript and_amphetamine-regulated_transcript|appos|END_ENTITY	Cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- is upregulated in islets of type-2 diabetic patients to stimulate insulin secretion , inhibit glucagon secretion and protect against beta cell death .
9704875	0	Cocaine	0,7	CART	47,51	Cocaine	CART	MESH:D003042	29131(Tax:10116)	Chemical	Gene	START_ENTITY|dep|neurons neurons|appos|END_ENTITY	Cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- peptide immunoreactivity in myenteric plexus neurons of the rat ileum and co-localization with choline_acetyltransferase .
24740629	0	Cocaine	0,7	CARTp	55,60	Cocaine	CARTp	MESH:D003042	29131(Tax:10116)	Chemical	Gene	Peptide|amod|START_ENTITY Peptide|appos|END_ENTITY	Cocaine - and Amphetamine-Regulated Transcript Peptide -LRB- CARTp -RRB- : Distribution and Function in Rat Urinary Bladder .
25212486	0	Cocaine	73,80	Dopamine_Transporter	96,116	Cocaine	Dopamine Transporter	MESH:D003042	6531	Chemical	Gene	Effects|compound|START_ENTITY Effects|nmod|Drug Drug|compound|END_ENTITY	Brief Intermittent Cocaine Self-Administration and Abstinence Sensitizes Cocaine Effects on the Dopamine_Transporter and Increases Drug Seeking .
25247548	0	Cocaine	6,13	Dopamine_Transporter	116,136	Cocaine	Dopamine Transporter	MESH:D003042	6531	Chemical	Gene	Show|compound|START_ENTITY Differences|nsubj|Show Differences|nmod|Frequencies Frequencies|nmod|Number Number|nmod|Repeats Repeats|nmod|Gene Gene|compound|END_ENTITY	Crack Cocaine Users Show Differences in Genotype Frequencies of the 3 ' UTR Variable Number of Tandem Repeats of the Dopamine_Transporter Gene -LRB- DAT1/SLC6A3 -RRB- .
25325348	0	Cocaine	0,7	Egr-1	34,39	Cocaine	Egr-1	MESH:D003042	24330(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|ubiquitination ubiquitination|nmod|END_ENTITY	Cocaine induces ubiquitination of Egr-1 in the rat dorsal striatum .
8964083	0	Cocaine	0,7	IL-8	64,68	Cocaine	IL-8	MESH:D003042	3576	Chemical	Gene	down-regulates|amod|START_ENTITY IL-2-induced|nsubj|down-regulates IL-2-induced|dobj|END_ENTITY	Cocaine down-regulates IL-2-induced peripheral blood lymphocyte IL-8 and IFN-gamma production .
9344494	0	Cocaine	0,7	IL-8	40,44	Cocaine	IL-8	MESH:D003042	3576	Chemical	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	Cocaine inhibits human endothelial cell IL-8 production : the role of transforming_growth_factor-beta .
18760698	0	Cocaine	0,7	MEF2	18,22	Cocaine	MEF2	MESH:D003042	4205	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Cocaine regulates MEF2 to control synaptic and behavioral plasticity .
21704097	0	Cocaine	0,7	MeCP2	37,42	Cocaine	MeCP2	MESH:D003042	29386(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Cocaine increases phosphorylation of MeCP2 in the rat striatum in vivo : a differential role of NMDA receptors .
25724654	0	Cocaine	121,128	Norepinephrine_Transporter	80,106	Cocaine	Norepinephrine Transporter	MESH:D003042	20538(Tax:10090)	Chemical	Gene	Sensitization|compound|START_ENTITY Role|nmod|Sensitization Role|nmod|Regulation Regulation|compound|END_ENTITY	A Role for p38_Mitogen-activated_Protein_Kinase-mediated Threonine 30-dependent Norepinephrine_Transporter Regulation in Cocaine Sensitization and Conditioned Place Preference .
25595128	0	Cocaine	0,7	Rac1	18,22	Cocaine	Rac1	MESH:D003042	5879	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Cocaine activates Rac1 to control structural and behavioral plasticity in caudate putamen .
12450069	0	Cocaine	0,7	SERCA2a	30,37	Cocaine	SERCA2a	MESH:D003042	11938(Tax:10090)	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	Cocaine downregulates cardiac SERCA2a and depresses_myocardial_function in the murine model .
21954104	0	Cocaine	0,7	SIK1	99,103	Cocaine	SIK1	MESH:D003042	59329(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Cocaine induces the expression of MEF2C transcription factor in rat striatum through activation of SIK1 and phosphorylation of the histone deacetylase HDAC5 .
21536109	0	Cocaine	0,7	ST8SiaII	17,25	Cocaine	ST8SiaII	MESH:D003042	117523(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Cocaine enhances ST8SiaII mRNA expression and neural_cell_adhesion_molecule polysialylation in the rat medial prefrontal cortex .
23632436	0	Cocaine	0,7	Zif268	51,57	Cocaine	Zif268	MESH:D003042	24330(Tax:10116)	Chemical	Gene	modulation|amod|START_ENTITY modulation|nmod|END_ENTITY	Cocaine modulation of frontostriatal expression of Zif268 , D2 , and 5-HT2c receptors in high and low impulsive rats .
7969045	0	Cocaine	0,7	activator_protein-1	33,52	Cocaine	activator protein-1	MESH:D003042	24516(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|levels levels|amod|END_ENTITY	Cocaine differentially regulates activator_protein-1 mRNA levels and DNA-binding complexes in the rat striatum and cerebellum .
18314190	0	Cocaine	0,7	c-Fos	113,118	Cocaine	c-Fos	MESH:D003042	314322(Tax:10116)	Chemical	Gene	administration|amod|START_ENTITY increases|nsubj|administration increases|ccomp|accumbens accumbens|dobj|co-immunostain co-immunostain|nmod|END_ENTITY	Cocaine administration increases the fraction of CART cells in the rat nucleus accumbens that co-immunostain for c-Fos .
12106364	0	Cocaine	28,35	c-fos	9,14	Cocaine	c-fos	MESH:D003042	314322(Tax:10116)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|compound|END_ENTITY	Striatal c-fos Induction by Cocaine or Apomorphine Occurs Preferentially in Output Neurons Projecting to the Substantia Nigra in the Rat .
12853329	0	Cocaine	0,7	c-fos	87,92	Cocaine	c-fos	MESH:D003042	314322(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|expression expression|nmod|genes genes|amod|END_ENTITY	Cocaine induces a dose-dependent alteration in the expression of immediate early genes c-fos and SP-1 and in nuclear factor NF-kappabeta in PC12 cells .
15541892	0	Cocaine	0,7	c-fos	64,69	Cocaine	c-fos	MESH:D003042	314322(Tax:10116)	Chemical	Gene	produces|nsubj|START_ENTITY produces|dobj|response response|amod|END_ENTITY	Cocaine pre-exposure produces a sensitized and context-specific c-fos mRNA response to footshock stress in the central nucleus of the AMYGDALA .
15955413	0	Cocaine	0,7	c-fos	56,61	Cocaine	c-fos	MESH:D003042	314322(Tax:10116)	Chemical	Gene	pre-exposure|amod|START_ENTITY enhances|nsubj|pre-exposure enhances|dobj|expression expression|nmod|mRNA mRNA|amod|END_ENTITY	Cocaine pre-exposure enhances CRF-induced expression of c-fos mRNA in the central nucleus of the amygdala : an effect that parallels the effects of cocaine pre-exposure on CRF-induced locomotor activity .
7709341	0	Cocaine	0,7	c-fos	35,40	Cocaine	c-fos	MESH:D003042	314322(Tax:10116)	Chemical	Gene	increase|amod|START_ENTITY END_ENTITY|nsubj|increase	Cocaine and d-amphetamine increase c-fos expression in the rat cerebellum .
16085363	0	Cocaine	0,7	catalase	15,23	Cocaine	catalase	MESH:D003042	12359(Tax:10090)	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|activity activity|amod|END_ENTITY	Cocaine alters catalase activity in prefrontal cortex and striatum of mice .
2823980	0	Cocaine	0,7	corticotropin-releasing_factor	66,96	Cocaine	corticotropin-releasing factor	MESH:D003042	81648(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|END_ENTITY	Cocaine stimulates adrenocorticotropin -LRB- ACTH -RRB- secretion through a corticotropin-releasing_factor -LRB- CRF -RRB- - mediated mechanism .
2611679	0	Cocaine	0,7	corticotropin-releasing_hormone	36,67	Cocaine	corticotropin-releasing hormone	MESH:D003042	81648(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|xcomp|rat rat|dobj|secretion secretion|amod|END_ENTITY	Cocaine stimulates rat hypothalamic corticotropin-releasing_hormone secretion in vitro .
10516315	0	Cocaine	0,7	dopamine_transporter	24,44	Cocaine	dopamine transporter	MESH:D003042	574143(Tax:9544)	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	Cocaine upregulates the dopamine_transporter in fetal rhesus_monkey brain .
10581396	0	Cocaine	0,7	dopamine_transporter	65,85	Cocaine	dopamine transporter	MESH:D003042	13162(Tax:10090)	Chemical	Gene	reward|amod|START_ENTITY reward|dep|alteration alteration|nmod|overexpression overexpression|compound|END_ENTITY	Cocaine reward and MPTP toxicity : alteration by regional variant dopamine_transporter overexpression .
11809869	0	Cocaine	0,7	dopamine_transporter	21,41	Cocaine	dopamine transporter	MESH:D003042	6531	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|trafficking trafficking|compound|END_ENTITY	Cocaine induction of dopamine_transporter trafficking to the plasma membrane .
12606774	0	Cocaine	0,7	dopamine_transporter	111,131	Cocaine	dopamine transporter	MESH:D003042	6531	Chemical	Gene	decreased|nsubj|START_ENTITY decreased|nmod|domain domain|nmod|END_ENTITY	Cocaine affinity decreased by mutations of aromatic residue phenylalanine 105 in the transmembrane domain 2 of dopamine_transporter .
16095575	0	Cocaine	0,7	dopamine_transporter	148,168	Cocaine	dopamine transporter	MESH:D003042	24898(Tax:10116)	Chemical	Gene	self-administration|amod|START_ENTITY altered|nsubjpass|self-administration altered|nmod|RTI_336 RTI_336|appos|analog analog|acl:relcl|binds binds|nmod|END_ENTITY	Cocaine self-administration and locomotor activity are altered in Lewis and F344 inbred rats by RTI_336 , a 3-phenyltropane analog that binds to the dopamine_transporter .
17584943	0	Cocaine	0,7	dopamine_transporter	63,83	Cocaine	dopamine transporter	MESH:D003042	13162(Tax:10090)	Chemical	Gene	reward|amod|START_ENTITY reward|nmod|mice mice|nmod|expression expression|compound|END_ENTITY	Cocaine reward and locomotion stimulation in mice with reduced dopamine_transporter expression .
22395730	0	Cocaine	0,7	dopamine_transporter	103,123	Cocaine	dopamine transporter	MESH:D003042	24898(Tax:10116)	Chemical	Gene	self-administration|amod|START_ENTITY produces|nsubj|self-administration produces|dobj|tolerance tolerance|dep|effects effects|nmod|potency potency|nmod|blockers blockers|compound|END_ENTITY	Cocaine self-administration produces pharmacodynamic tolerance : differential effects on the potency of dopamine_transporter blockers , releasers , and methylphenidate .
9135047	0	Cocaine	0,7	dopamine_transporter	91,111	Cocaine	dopamine transporter	MESH:D003042	6531	Chemical	Gene	START_ENTITY|nmod|rats rats|nmod|injection injection|nmod|oligodeoxynucleotides oligodeoxynucleotides|compound|END_ENTITY	Cocaine and amphetamine elicit differential effects in rats with a unilateral injection of dopamine_transporter antisense oligodeoxynucleotides .
9689064	0	Cocaine	0,7	dopamine_transporter	120,140	Cocaine	dopamine transporter	MESH:D003042	6531	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|accessibility accessibility|nmod|cysteines cysteines|nmod|extracellular extracellular|nmod|END_ENTITY	Cocaine alters the accessibility of endogenous cysteines in putative extracellular and intracellular loops of the human dopamine_transporter .
8594297	0	Cocaine	0,7	hCG	17,20	Cocaine	hCG	MESH:D003042	3342	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|compound|END_ENTITY	Cocaine inhibits hCG secretion by the human term placental cotyledon perfused in vitro .
17849098	0	Cocaine	0,7	immunoglobulin_heavy_chain_binding_protein	18,60	Cocaine	immunoglobulin heavy chain binding protein	MESH:D003042	25617(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Cocaine increases immunoglobulin_heavy_chain_binding_protein and caspase-12 expression in the rat dorsal striatum .
9787120	0	Cocaine	0,7	interferon-gamma	27,43	Cocaine	interferon-gamma	MESH:D003042	3458	Chemical	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	Cocaine infusion increases interferon-gamma and decreases interleukin-10 in cocaine-dependent subjects .
25829143	0	Cocaine	0,7	mGluR5	100,106	Cocaine	mGluR5	MESH:D003042	14805(Tax:10090)	Chemical	Gene	mGluR1|compound|START_ENTITY Currents|nsubj|mGluR1 Currents|nmod|Activating Activating|nummod|END_ENTITY	Cocaine Decreases Metabotropic Glutamate Receptor mGluR1 Currents in Dopamine Neurons by Activating mGluR5 .
22300446	0	Cocaine	0,7	neurogranin	32,43	Cocaine	neurogranin	MESH:D003042	64011(Tax:10090)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|nmod|END_ENTITY	Cocaine decreases expression of neurogranin via alterations in thyroid receptor/retinoid X receptor signaling .
10611457	0	Cocaine	0,7	norepinephrine_transporter	21,47	Cocaine	norepinephrine transporter	MESH:D003042	83511(Tax:10116)	Chemical	Gene	up-regulates|amod|START_ENTITY END_ENTITY|nsubj|up-regulates	Cocaine up-regulates norepinephrine_transporter binding in the rat placenta .
21498515	0	Cocaine	0,7	norepinephrine_transporter	29,55	Cocaine	norepinephrine transporter	MESH:D003042	6530	Chemical	Gene	up-regulation|amod|START_ENTITY up-regulation|nmod|END_ENTITY	Cocaine up-regulation of the norepinephrine_transporter requires threonine 30 phosphorylation by p38_mitogen-activated_protein_kinase .
9852563	0	Cocaine	0,7	norepinephrine_transporter	98,124	Cocaine	norepinephrine transporter	MESH:D003042	6530	Chemical	Gene	acts|amod|START_ENTITY acts|nmod|inhibitor inhibitor|nmod|conformation conformation|nmod|END_ENTITY	Cocaine acts as an apparent competitive inhibitor at the outward-facing conformation of the human norepinephrine_transporter : kinetic analysis of inward and outward transport .
7873692	0	Cocaine	0,7	ornithine_decarboxylase	84,107	Cocaine	ornithine decarboxylase	MESH:D003042	24609(Tax:10116)	Chemical	Gene	exacerbates|nsubj|START_ENTITY exacerbates|dobj|damage damage|dep|effects effects|nmod|activity activity|amod|END_ENTITY	Cocaine exacerbates hypoxia-induced cell damage in the developing brain : effects on ornithine_decarboxylase activity and protein synthesis .
15365088	0	Cocaine	0,7	p38_mitogen-activated_protein_kinase	68,104	Cocaine	p38 mitogen-activated protein kinase	MESH:D003042	81649(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Cocaine induces apoptosis in fetal rat myocardial cells through the p38_mitogen-activated_protein_kinase and mitochondrial/cytochrome c pathways .
21498515	0	Cocaine	0,7	p38_mitogen-activated_protein_kinase	97,133	Cocaine	p38 mitogen-activated protein kinase	MESH:D003042	1432	Chemical	Gene	up-regulation|amod|START_ENTITY requires|nsubj|up-regulation requires|advcl|END_ENTITY	Cocaine up-regulation of the norepinephrine_transporter requires threonine 30 phosphorylation by p38_mitogen-activated_protein_kinase .
14691017	0	Cocaine	0,7	thyrotropin-releasing_hormone	62,91	Cocaine	thyrotropin-releasing hormone	MESH:D003042	25569(Tax:10116)	Chemical	Gene	START_ENTITY|parataxis|modulates modulates|nsubj|co-contained co-contained|nmod|neurons neurons|amod|END_ENTITY	Cocaine - _ and_amphetamine-regulated_transcript co-contained in thyrotropin-releasing_hormone -LRB- TRH -RRB- neurons of the hypothalamic paraventricular nucleus modulates TRH-induced prolactin secretion .
9344494	0	Cocaine	0,7	transforming_growth_factor-beta	69,100	Cocaine	transforming growth factor-beta	MESH:D003042	7040	Chemical	Gene	production|compound|START_ENTITY production|dep|role role|nmod|END_ENTITY	Cocaine inhibits human endothelial cell IL-8 production : the role of transforming_growth_factor-beta .
19656872	0	Cochaperone	0,11	butyrate-induced_transcript_1	30,59	Cochaperone	butyrate-induced transcript 1	null	51495	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Cochaperone activity of human butyrate-induced_transcript_1 facilitates hepatitis_C virus replication through an Hsp90-dependent pathway .
22885103	0	Coenzyme_Q10	0,12	PPARa	70,75	Coenzyme Q10	PPARa	MESH:C024989	5465	Chemical	Gene	increases|nsubj|START_ENTITY increases|nmod|END_ENTITY	Coenzyme_Q10 increases the fatty_acid oxidation through AMPK-mediated PPARa induction in 3T3-L1 preadipocytes .
18806307	0	Coenzyme_Q10	11,23	TNF-alpha	27,36	Coenzyme Q10	TNF-alpha	MESH:C024989	7124	Chemical	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	Effects of Coenzyme_Q10 on TNF-alpha secretion in human and murine monocytic cell lines .
20354351	0	Coenzyme_Q10	0,12	TNF-alpha	23,32	Coenzyme Q10	TNF-alpha	MESH:C024989	7124	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|secretion secretion|amod|END_ENTITY	Coenzyme_Q10 decreases TNF-alpha and IL-2 secretion by human peripheral blood mononuclear cells .
7637588	0	Colchicine	0,10	GAP-43	23,29	Colchicine	GAP-43	MESH:D003078	29423(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Colchicine induces the GAP-43 gene expression in rat hypothalamus .
24759273	0	Colchicine	0,10	P-glycoprotein	21,35	Colchicine	P-glycoprotein	MESH:D003078	5243	Chemical	Gene	effect|amod|START_ENTITY effect|nmod|expression expression|amod|END_ENTITY	Colchicine effect on P-glycoprotein expression and activity : in silico and in vitro studies .
17597159	0	Colchicine	0,10	VEGF	54,58	Colchicine	VEGF	MESH:D003078	403802(Tax:9615)	Chemical	Gene	START_ENTITY|dobj|expression expression|compound|END_ENTITY	Colchicine inhibits_intimal_hyperplasia and leukocyte VEGF expression in dogs .
14978665	0	Colchicine	0,10	familial_Mediterranean_fever	32,60	Colchicine	familial Mediterranean fever	MESH:D003078	4210	Chemical	Gene	nonresponsiveness|amod|START_ENTITY nonresponsiveness|nmod|END_ENTITY	Colchicine nonresponsiveness in familial_Mediterranean_fever : clinical , genetic , pharmacokinetic , and socioeconomic characterization .
2042056	0	Colchicine	0,10	familial_Mediterranean_fever	26,54	Colchicine	familial Mediterranean fever	MESH:D003078	4210	Chemical	Gene	prophylaxis|amod|START_ENTITY prophylaxis|nmod|END_ENTITY	Colchicine prophylaxis in familial_Mediterranean_fever : reappraisal after 15 years .
22738946	0	Colchicine	0,10	familial_Mediterranean_fever	43,71	Colchicine	familial Mediterranean fever	MESH:D003078	4210	Chemical	Gene	drug|nsubj|START_ENTITY drug|nmod|children children|nmod|END_ENTITY	Colchicine is a safe drug in children with familial_Mediterranean_fever .
7986228	0	Colchicine	0,10	familial_Mediterranean_fever	42,70	Colchicine	familial Mediterranean fever	MESH:D003078	4210	Chemical	Gene	treatment|amod|START_ENTITY amyloidosis|nsubj|treatment amyloidosis|nmod|END_ENTITY	Colchicine treatment of AA amyloidosis of familial_Mediterranean_fever .
3096338	0	Colchicine	0,10	lactase	32,39	Colchicine	lactase	MESH:D003078	116569(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Colchicine selectively inhibits lactase expression by rat enterocytes .
2961368	0	Colchicine	0,10	parathyroid_hormone	32,51	Colchicine	parathyroid hormone	MESH:D003078	5741	Chemical	Gene	blocks|nsubj|START_ENTITY blocks|dobj|action action|nmod|END_ENTITY	Colchicine blocks the action of parathyroid_hormone but not nicotinamide on renal phosphate transport .
7189542	0	Colchicine	0,10	retinol-binding_protein	25,48	Colchicine	retinol-binding protein	MESH:D003078	25703(Tax:10116)	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|secretion secretion|amod|END_ENTITY	Colchicine inhibition of retinol-binding_protein secretion by rat liver .
26169405	0	Colistin	22,30	Mucin	0,5	Colistin	Mucin	MESH:D003091	100508689	Chemical	Gene	Activity|compound|START_ENTITY Activity|compound|END_ENTITY	Mucin Binding Reduces Colistin Antimicrobial Activity .
21671007	0	Combretastatin-A4	80,97	Bim	8,11	Combretastatin-A4	Bim	MESH:C058728	10018	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Role Role|nmod|END_ENTITY	Role of Bim in apoptosis induced in H460_lung_tumor cells by the spindle poison Combretastatin-A4 .
14728944	0	Combretastatin_A-4_phosphate	0,28	CPT-11	38,44	Combretastatin A-4 phosphate	CPT-11	MESH:C058728	963084(Tax:115711)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|compound|END_ENTITY	Combretastatin_A-4_phosphate enhances CPT-11 activity independently of the administration sequence .
24930830	0	Complanadine_A	0,14	Mas-related_G_protein-coupled_receptor_X2	44,85	Complanadine A	Mas-related G protein-coupled receptor X2	MESH:C550939	117194	Chemical	Gene	START_ENTITY|appos|agonist agonist|nmod|END_ENTITY	Complanadine_A , a selective agonist for the Mas-related_G_protein-coupled_receptor_X2 .
2446494	0	Concanavalin_A	0,14	alpha-fetoprotein	27,44	Concanavalin A	alpha-fetoprotein	null	174	Chemical	Gene	affinity|compound|START_ENTITY affinity|nmod|END_ENTITY	Concanavalin_A affinity of alpha-fetoprotein .
6169467	0	Concanavalin_A	0,14	alpha-fetoprotein	26,43	Concanavalin A	alpha-fetoprotein	null	174	Chemical	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	Concanavalin_A binding of alpha-fetoprotein in amniotic fluid as an aid in the diagnosis of neural_tube_defects .
6272237	0	Concanavalin_A	0,14	pregnancy-specific_beta-1-glycoprotein	26,64	Concanavalin A	pregnancy-specific beta-1-glycoprotein	null	653492	Chemical	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	Concanavalin_A binding of pregnancy-specific_beta-1-glycoprotein in normal pregnancy and trophoblastic_disease .
16281086	0	Contragestazol	0,14	PC3	105,108	Contragestazol	PC3	MESH:C030266	5122	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|proliferation proliferation|nmod|END_ENTITY	Contragestazol -LRB- DL111-IT -RRB- inhibits proliferation of human androgen-independent prostate_cancer cell line PC3 in vitro and in vivo .
9606958	0	Convulxin	0,9	PLC_gamma_2	149,160	Convulxin	PLC gamma 2	MESH:C028890	5336	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Convulxin induces platelet activation by a tyrosine-kinase-dependent pathway and stimulates tyrosine phosphorylation of platelet proteins , including PLC_gamma_2 , independently of integrin alpha IIb beta 3 .
17110380	0	Coordinate	0,10	ERBB2	26,31	Coordinate	ERBB2	null	2064	Chemical	Gene	suppression|amod|START_ENTITY suppression|nmod|END_ENTITY	Coordinate suppression of ERBB2 and ERBB3 by enforced expression of micro-RNA miR-125a or miR-125b .
18773970	0	Coordinate	0,10	PPAR_alpha	24,34	Coordinate	PPAR alpha	null	19013(Tax:10090)	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Coordinate induction of PPAR_alpha and SREBP2 in multifunctional_protein_2 deficient mice .
8138590	0	Coordinate	0,10	alpha_B-crystallin	41,59	Coordinate	alpha B-crystallin	null	25420(Tax:10116)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Coordinate and independent regulation of alpha_B-crystallin and hsp27 expression in response to physiological stress .
9886832	0	Coordinate	0,10	corticotropin-releasing_factor	39,69	Coordinate	corticotropin-releasing factor	null	1392	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Coordinate and divergent regulation of corticotropin-releasing_factor -LRB- CRF -RRB- and CRF-binding_protein expression in an immortalized amygdalar neuronal cell line .
15589846	0	Coordinate	0,10	cysteine_protease	26,43	Coordinate	cysteine protease	null	1508	Chemical	Gene	involvement|amod|START_ENTITY involvement|nmod|END_ENTITY	Coordinate involvement of cysteine_protease and nuclease in the executive phase of plant apoptosis .
8424468	0	Coordinate	0,10	interleukin-1	37,50	Coordinate	interleukin-1	null	3552	Chemical	Gene	synthesis|amod|START_ENTITY synthesis|nmod|END_ENTITY	Coordinate synthesis of stromelysin , interleukin-1 , and oncogene proteins in experimental osteoarthritis .
1680339	0	Coordinate	0,10	mdr2	69,73	Coordinate	mdr2	null	18670(Tax:10090)	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Coordinate activation of multidrug-resistance -LRB- P-glycoprotein -RRB- genes mdr2 and mdr3 during mouse liver_regeneration .
3742722	0	Coordinate	0,10	metallothionein_I	50,67	Coordinate	metallothionein I	null	17748(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|activation activation|nmod|END_ENTITY	Coordinate activation and regulation of quiescent metallothionein_I and II genes in carcinogen-treated mouse thymic_lymphoma cells .
17110380	0	Coordinate	0,10	miR-125a	78,86	Coordinate	miR-125a	null	406910	Chemical	Gene	suppression|amod|START_ENTITY suppression|amod|END_ENTITY	Coordinate suppression of ERBB2 and ERBB3 by enforced expression of micro-RNA miR-125a or miR-125b .
9379855	0	Coordinate	0,10	ngfi-a	35,41	Coordinate	ngfi-a	null	1958	Chemical	Gene	suppression|amod|START_ENTITY suppression|nmod|END_ENTITY	Coordinate suppression of striatal ngfi-a and c-fos produces locomotor asymmetry and up-regulation of IEGs in the globus pallidus .
1970506	0	Coordinate	0,10	phenylethanolamine_N-methyltransferase	42,80	Coordinate	phenylethanolamine N-methyltransferase	null	281413(Tax:9913)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Coordinate and differential regulation of phenylethanolamine_N-methyltransferase , tyrosine_hydroxylase and proenkephalin mRNAs by neural and hormonal mechanisms in cultured bovine adrenal medullary cells .
23669644	0	Copper	0,6	APP	16,19	Copper	APP	MESH:D003300	351	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|dimerization dimerization|compound|END_ENTITY	Copper enhances APP dimerization and promotes Ab production .
21473932	0	Copper	0,6	ATP7A	25,30	Copper	ATP7A	MESH:D003300	1769	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|mRNA mRNA|compound|END_ENTITY	Copper induces Cu-ATPase ATP7A mRNA in a fish cell line , SAF1 .
10973814	0	Copper	0,6	ATP7B	56,61	Copper	ATP7B	MESH:D003300	540	Chemical	Gene	alter|nsubj|START_ENTITY alter|dobj|distribution distribution|nmod|END_ENTITY	Copper does not alter the intracellular distribution of ATP7B , a copper-transporting ATPase .
15134922	0	Copper	0,6	ATP7B	72,77	Copper	ATP7B	MESH:D003300	540	Chemical	Gene	transfer|compound|START_ENTITY transfer|nmod|domain domain|nmod|protein protein|appos|END_ENTITY	Copper transfer to the N-terminal domain of the Wilson_disease protein -LRB- ATP7B -RRB- : X-ray absorption spectroscopy of reconstituted and chaperone-loaded metal_binding_domains and their interaction with exogenous ligands .
16939419	0	Copper	0,6	ATP7B	147,152	Copper	ATP7B	MESH:D003300	540	Chemical	Gene	essential|nsubj|START_ENTITY essential|nmod|trafficking trafficking|nmod|protein protein|appos|END_ENTITY	Copper binding to the N-terminal metal-binding sites or the CPC motif is not essential for copper-induced trafficking of the human Wilson protein -LRB- ATP7B -RRB- .
17786364	0	Copper	0,6	ATP7B	27,32	Copper	ATP7B	MESH:D003300	540	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Copper efflux transporter -LRB- ATP7B -RRB- contributes to the acquisition of cisplatin-resistance in human oral squamous cell lines .
26758278	0	Copper	18,24	ATP7B	87,92	Copper	ATP7B	MESH:D003300	540	Chemical	Gene	Subtypes|compound|START_ENTITY Subtypes|dep|Study Study|nmod|Frequency Frequency|compound|END_ENTITY	Non-Ceruloplasmin Copper Distincts Subtypes in Alzheimer 's _ Disease : a Genetic Study of ATP7B Frequency .
26797276	0	Copper	0,6	ATP7B	75,80	Copper	ATP7B	MESH:D003300	540	Chemical	Gene	binding|compound|START_ENTITY triggers|nsubj|binding triggers|nmod|tail tail|nmod|END_ENTITY	Copper binding triggers compaction in N-terminal tail of human copper pump ATP7B .
26819212	0	Copper	30,36	ATP7B	99,104	Copper	ATP7B	MESH:D003300	540	Chemical	Gene	Subtypes|compound|START_ENTITY Erratum|dep|Subtypes Erratum|dep|Study Study|nmod|Frequency Frequency|compound|END_ENTITY	Erratum to : Non-Ceruloplasmin Copper Distincts Subtypes in Alzheimer 's _ Disease : a Genetic Study of ATP7B Frequency .
9794921	0	Copper	0,6	ATP7B	102,107	Copper	ATP7B	MESH:D003300	540	Chemical	Gene	resistant|advmod|START_ENTITY lines|amod|resistant overexpress|nsubj|lines overexpress|dobj|END_ENTITY	Copper resistant human hepatoblastoma mutant cell lines without metallothionein induction overexpress ATP7B .
23468063	0	Copper	0,6	Bmi-1	100,105	Copper	Bmi-1	MESH:D003300	648	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|downregulation downregulation|nmod|END_ENTITY	Copper induces cellular senescence in human glioblastoma_multiforme cells through downregulation of Bmi-1 .
24485600	0	Copper	0,6	CTR1	46,50	Copper	CTR1	MESH:D003300	1317	Chemical	Gene	hormones|compound|START_ENTITY influence|nsubj|hormones influence|dobj|transporter transporter|compound|END_ENTITY	Copper and lactational hormones influence the CTR1 copper transporter in PMC42-LA mammary epithelial cell culture models .
24792335	0	Copper	0,6	CTR1	19,23	Copper	CTR1	MESH:D003300	1317	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|nsubj|transporter	Copper transporter CTR1 expression and tissue platinum concentration in non-small_cell_lung_cancer .
19088072	0	Copper	0,6	Ctr1	35,39	Copper	Ctr1	MESH:D003300	856241(Tax:4932)	Chemical	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Copper transport activity of yeast Ctr1 is down-regulated via its C terminus in response to excess copper .
25794362	0	Copper	128,134	Ctr1	148,152	Copper	Ctr1	MESH:D003300	1317	Chemical	Gene	Transporter|compound|START_ENTITY Domain|nmod|Transporter Interacts|nmod|Domain Protein|appos|Interacts END_ENTITY|nsubj|Protein	EPR Spectroscopy Shows that the Blood Carrier Protein , Human Serum Albumin , Closely Interacts with the N-Terminal Domain of the Copper Transporter , Ctr1 .
12011036	0	Copper	0,6	Ctr1p	119,124	Copper	Ctr1p	MESH:D003300	856241(Tax:4932)	Chemical	Gene	Mac1p|compound|START_ENTITY controls|nsubj|Mac1p controls|dobj|degradation degradation|nmod|END_ENTITY	Copper ion-sensing transcription factor Mac1p post-translationally controls the degradation of its target gene product Ctr1p .
3027598	0	Copper	0,6	LHRH	22,26	Copper	LHRH	MESH:D003300	25194(Tax:10116)	Chemical	Gene	stimulation|compound|START_ENTITY stimulation|nmod|END_ENTITY	Copper stimulation of LHRH release from median eminence explants .
3093908	0	Copper	0,6	LHRH	22,26	Copper	LHRH	MESH:D003300	25194(Tax:10116)	Chemical	Gene	stimulation|compound|START_ENTITY stimulation|nmod|END_ENTITY	Copper stimulation of LHRH release from median eminence explants .
3543716	0	Copper	0,6	LHRH	22,26	Copper	LHRH	MESH:D003300	2796	Chemical	Gene	stimulation|compound|START_ENTITY stimulation|nmod|END_ENTITY	Copper stimulation of LHRH release from median eminence explants .
19747488	0	Copper	0,6	NF-kappaB	21,30	Copper	NF-kappaB	MESH:D003300	4790	Chemical	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Copper activation of NF-kappaB signaling in HepG2 cells .
11483731	0	Copper	0,6	PrP	22,25	Copper	PrP	MESH:D003300	5621	Chemical	Gene	START_ENTITY|nmod|isoforms isoforms|compound|END_ENTITY	Copper binding to the PrP isoforms : a putative marker of their conformation and function .
14642846	0	Copper	0,6	PrPC	18,22	Copper	PrPC	MESH:D003300	5621	Chemical	Gene	START_ENTITY|amod|binding binding|nmod|END_ENTITY	Copper binding to PrPC may inhibit prion_disease propagation .
23144499	0	Copper	53,59	Prion_Protein	82,95	Copper	Prion Protein	MESH:D003300	5621	Chemical	Gene	Electrochemistry|nmod|START_ENTITY Sites|nsubj|Electrochemistry Sites|nmod|END_ENTITY	The Rich Electrochemistry and Redox Reactions of the Copper Sites in the Cellular Prion_Protein .
25541747	0	Copper	30,36	Prion_Protein	77,90	Copper	Prion Protein	MESH:D003300	5621	Chemical	Gene	Binding|compound|START_ENTITY Binding|nmod|Region Region|nmod|END_ENTITY	Calorimetric Investigation of Copper Binding in the N-Terminal Region of the Prion_Protein at Low Copper Loading : Evidence for an Entropically Favorable First Binding Event .
25541747	0	Copper	98,104	Prion_Protein	77,90	Copper	Prion Protein	MESH:D003300	5621	Chemical	Gene	Loading|compound|START_ENTITY END_ENTITY|nmod|Loading	Calorimetric Investigation of Copper Binding in the N-Terminal Region of the Prion_Protein at Low Copper Loading : Evidence for an Entropically Favorable First Binding Event .
7657651	0	Copper	0,6	S-adenosylhomocysteine_hydrolase	30,62	Copper	S-adenosylhomocysteine hydrolase	MESH:D003300	269378(Tax:10090)	Chemical	Gene	binding|nsubj|START_ENTITY binding|nmod|END_ENTITY	Copper binding to mouse liver S-adenosylhomocysteine_hydrolase and the effects of copper on its levels .
16766622	0	Copper	0,6	S100A13	27,34	Copper	S100A13	MESH:D003300	6284	Chemical	Gene	affinity|compound|START_ENTITY affinity|nmod|END_ENTITY	Copper binding affinity of S100A13 , a key component of the FGF-1 nonclassical copper-dependent release complex .
10944535	0	Copper	0,6	SOD1	45,49	Copper	SOD1	MESH:D003300	853568(Tax:4932)	Chemical	Gene	activation|compound|START_ENTITY activation|appos|END_ENTITY	Copper activation of superoxide_dismutase_1 -LRB- SOD1 -RRB- in vivo .
19122104	0	Copper	67,73	SQUAMOSA_Promoter_Binding_Protein-Like7	0,39	Copper	SQUAMOSA Promoter Binding Protein-Like7	MESH:D003300	832001(Tax:3702)	Chemical	Gene	Homeostasis|compound|START_ENTITY Regulator|nmod|Homeostasis Regulator|nsubj|END_ENTITY	SQUAMOSA_Promoter_Binding_Protein-Like7 Is a Central Regulator for Copper Homeostasis in Arabidopsis .
17520746	0	Copper	0,6	TrkB	17,21	Copper	TrkB	MESH:D003300	4915	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Copper activates TrkB in cortical neurons in a metalloproteinase-dependent manner .
24473150	0	Copper	0,6	acetylcholinesterase	49,69	Copper	acetylcholinesterase	MESH:D003300	43	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|END_ENTITY	Copper , aluminum , iron and calcium inhibit human acetylcholinesterase in vitro .
9224688	0	Copper	0,6	activator_protein_1	57,76	Copper	activator protein 1	MESH:D003300	3726	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Copper and cell-oxidized low-density lipoprotein induces activator_protein_1 in fibroblasts , endothelial and smooth muscle cells .
16203684	0	Copper	0,6	amyloid_precursor_protein	34,59	Copper	amyloid precursor protein	MESH:D003300	351	Chemical	Gene	homeostasis|compound|START_ENTITY homeostasis|dep|role role|nmod|END_ENTITY	Copper brain homeostasis : role of amyloid_precursor_protein and prion_protein .
20213275	0	Copper	0,6	carboxy-terminus_of_trefoil_protein_1	17,54	Copper	carboxy-terminus of trefoil protein 1	MESH:D003300	117270(Tax:10116)	Chemical	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Copper binds the carboxy-terminus_of_trefoil_protein_1 -LRB- TFF1 -RRB- , favoring its homodimerization and motogenic activity .
15032831	0	Copper	0,6	cytochrome_b	17,29	Copper	cytochrome b	MESH:D003300	4519	Chemical	Gene	effect|compound|START_ENTITY effect|nmod|END_ENTITY	Copper effect on cytochrome_b of photosystem II under photoinhibitory conditions .
7037371	0	Copper	0,6	luteinizing_hormone_releasing_hormone	33,70	Copper	luteinizing hormone releasing hormone	MESH:D003300	25194(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|nmod|END_ENTITY	Copper stimulates the release of luteinizing_hormone_releasing_hormone from isolated hypothalamic granules .
10716185	0	Copper	0,6	prion_protein	45,58	Copper	prion protein	MESH:D003300	5621	Chemical	Gene	START_ENTITY|amod|binding binding|nmod|peptides peptides|nmod|END_ENTITY	Copper binding to octarepeat peptides of the prion_protein monitored by mass spectrometry .
10720484	0	Copper	0,6	prion_protein	34,47	Copper	prion protein	MESH:D003300	19122(Tax:10090)	Chemical	Gene	has|nsubj|START_ENTITY has|dobj|effect effect|nmod|END_ENTITY	Copper has differential effect on prion_protein with polymorphism of position 129 .
11027613	0	Copper	0,6	prion_protein	20,33	Copper	prion protein	MESH:D003300	19122(Tax:10090)	Chemical	Gene	refolding|compound|START_ENTITY refolding|nmod|END_ENTITY	Copper refolding of prion_protein .
11278539	0	Copper	0,6	prion_protein	29,42	Copper	prion protein	MESH:D003300	19122(Tax:10090)	Chemical	Gene	converts|nsubj|START_ENTITY converts|dobj|END_ENTITY	Copper converts the cellular prion_protein into a protease-resistant species that is distinct from the scrapie isoform .
12454014	0	Copper	0,6	prion_protein	41,54	Copper	prion protein	MESH:D003300	5621	Chemical	Gene	START_ENTITY|nmod|octarepeats octarepeats|nmod|END_ENTITY	Copper binding to the octarepeats of the prion_protein .
12779334	0	Copper	0,6	prion_protein	52,65	Copper	prion protein	MESH:D003300	101829062	Chemical	Gene	coordination|compound|START_ENTITY coordination|nmod|END_ENTITY	Copper coordination in the full-length , recombinant prion_protein .
14511113	0	Copper	0,6	prion_protein	38,51	Copper	prion protein	MESH:D003300	5621	Chemical	Gene	delivery|compound|START_ENTITY delivery|nmod|END_ENTITY	Copper and zinc cause delivery of the prion_protein from the plasma membrane to a subset of early endosomes and the Golgi .
14969585	0	Copper	0,6	prion_protein	77,90	Copper	prion protein	MESH:D003300	5621	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|content content|nmod|PrPVRQ PrPVRQ|compound|END_ENTITY	Copper induces increased beta-sheet content in the scrapie-susceptible ovine prion_protein PrPVRQ compared with the resistant allelic variant PrPARR .
16084105	0	Copper	0,6	prion_protein	47,60	Copper	prion protein	MESH:D003300	5621	Chemical	Gene	binding|compound|START_ENTITY determinant|nsubj|binding determinant|nmod|turnover turnover|compound|END_ENTITY	Copper binding is the governing determinant of prion_protein turnover .
17371047	0	Copper	0,6	prion_protein	107,120	Copper	prion protein	MESH:D003300	5621	Chemical	Gene	promote|nsubj|START_ENTITY promote|dobj|interactions interactions|nmod|peptides peptides|nmod|domain domain|nmod|END_ENTITY	Copper and zinc promote interactions between membrane-anchored peptides of the metal binding domain of the prion_protein .
17876822	0	Copper	0,6	prion_protein	55,68	Copper	prion protein	MESH:D003300	19122(Tax:10090)	Chemical	Gene	sites|compound|START_ENTITY sites|nmod|domain domain|nmod|END_ENTITY	Copper binding sites in the C-terminal domain of mouse prion_protein : A hybrid -LRB- QM/MM -RRB- molecular dynamics study .
17922496	0	Copper	0,6	prion_protein	69,82	Copper	prion protein	MESH:D003300	5621	Chemical	Gene	START_ENTITY|nmod|octarepeats octarepeats|nmod|END_ENTITY	Copper binding and conformation of the N-terminal octarepeats of the prion_protein in the presence of DPC micelles as membrane mimetic .
19538144	0	Copper	0,6	prion_protein	57,70	Copper	prion protein	MESH:D003300	5621	Chemical	Gene	extrinsic|compound|START_ENTITY extrinsic|nmod|region region|nmod|END_ENTITY	Copper binding extrinsic to the octarepeat region in the prion_protein .
19883942	0	Copper	0,6	prion_protein	36,49	Copper	prion protein	MESH:D003300	5621	Chemical	Gene	START_ENTITY|amod|binding binding|nmod|regions regions|compound|END_ENTITY	Copper binding to chicken and human prion_protein amylodogenic regions : differences and similarities revealed by Ni2 + as a diamagnetic probe .
20515743	0	Copper	0,6	prion_protein	42,55	Copper	prion protein	MESH:D003300	5621	Chemical	Gene	START_ENTITY|appos|processing processing|nmod|signalling signalling|compound|END_ENTITY	Copper , endoproteolytic processing of the prion_protein and cell signalling .
21707094	0	Copper	0,6	prion_protein	28,41	Copper	prion protein	MESH:D003300	5621	Chemical	Gene	cycling|compound|START_ENTITY cycling|nmod|END_ENTITY	Copper redox cycling in the prion_protein depends critically on binding mode .
21900252	0	Copper	0,6	prion_protein	38,51	Copper	prion protein	MESH:D003300	5621	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|behavior behavior|nmod|END_ENTITY	Copper alters aggregation behavior of prion_protein and induces novel interactions between its N - and C-terminal regions .
7864852	0	Copper	0,6	prion_protein	78,91	Copper	prion protein	MESH:D003300	5621	Chemical	Gene	START_ENTITY|dep|regions regions|nmod|END_ENTITY	Copper binding to the N-terminal tandem repeat regions of mammalian and avian prion_protein .
9837873	0	Copper	0,6	prion_protein	37,50	Copper	prion protein	MESH:D003300	5621	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|endocytosis endocytosis|nmod|END_ENTITY	Copper stimulates endocytosis of the prion_protein .
10944535	0	Copper	0,6	superoxide_dismutase_1	21,43	Copper	superoxide dismutase 1	MESH:D003300	853568(Tax:4932)	Chemical	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Copper activation of superoxide_dismutase_1 -LRB- SOD1 -RRB- in vivo .
16914587	0	Copper	0,6	superoxide_dismutase_1	116,138	Copper	superoxide dismutase 1	MESH:D003300	6647	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|nmod|inhibition inhibition|nmod|END_ENTITY	Copper binding by tetrathiomolybdate attenuates angiogenesis and tumor cell proliferation through the inhibition of superoxide_dismutase_1 .
25224745	0	Copper	0,6	synaptotagmin-1	45,60	Copper	synaptotagmin-1	MESH:D003300	6857	Chemical	Gene	affinity|compound|START_ENTITY affinity|nmod|domain domain|nmod|END_ENTITY	Copper binding affinity of the C2B domain of synaptotagmin-1 and its potential role in the nonclassical secretion of acidic fibroblast growth factor .
26258261	0	Copper	92,98	tcrB	116,120	Copper	tcrB	MESH:D003300	106506754	Chemical	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Effects of In-Feed Copper , Chlortetracycline , and Tylosin on the Prevalence of Transferable Copper Resistance Gene , tcrB , Among Fecal Enterococci of Weaned Piglets .
18629952	0	Copper	0,6	transferrin	42,53	Copper	transferrin	MESH:D003300	7018	Chemical	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	Copper binding and release by immobilized transferrin : a new approach to heavy metal removal and recovery .
22572742	0	Copper-zinc_superoxide	0,22	SOD1	34,38	Copper-zinc superoxide	SOD1	null	24786(Tax:10116)	Chemical	Gene	dismutase|amod|START_ENTITY dismutase|appos|END_ENTITY	Copper-zinc_superoxide dismutase -LRB- SOD1 -RRB- is released by microglial cells and confers neuroprotection against 6-OHDA neurotoxicity .
24286368	0	Cordycepin	0,10	AMP-activated_protein_kinase	21,49	Cordycepin	AMP-activated protein kinase	MESH:C058120	5563	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Cordycepin activates AMP-activated_protein_kinase -LRB- AMPK -RRB- via interaction with the y1 subunit .
24086728	0	Cordycepin	0,10	GSK-3b	21,27	Cordycepin	GSK-3b	MESH:C058120	2932	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	Cordycepin regulates GSK-3b / b-catenin signaling in human leukemia cells .
19056796	0	Cordycepin	0,10	MMP-1	37,42	Cordycepin	MMP-1	MESH:C058120	4312	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Cordycepin inhibits IL-1beta-induced MMP-1 and MMP-3 expression in rheumatoid_arthritis synovial fibroblasts .
20043135	0	Cordycepin	0,10	matrix_metalloproteinase-9	32,58	Cordycepin	matrix metalloproteinase-9	MESH:C058120	4318	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Cordycepin inhibits TPA-induced matrix_metalloproteinase-9 expression by suppressing the MAPK/AP -1 pathway in MCF-7 human breast_cancer cells .
26946098	0	Corilagin	10,19	miR-21	27,33	Corilagin	miR-21	MESH:C049096	387140(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of Corilagin on the miR-21 / smad7/ERK signaling pathway in a schistosomiasis-induced hepatic_fibrosis mouse model .
15256748	0	Corosolic_acid	0,14	GLUT4	23,28	Corosolic acid	GLUT4	MESH:C113861	20528(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|translocation translocation|nummod|END_ENTITY	Corosolic_acid induces GLUT4 translocation in genetically type 2 diabetic mice .
19407218	0	Cortagine	0,9	CRF1	13,17	Cortagine	CRF1	MESH:C488590	58959(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Cortagine , a CRF1 agonist , induces stresslike alterations of colonic function and visceral_hypersensitivity in rodents primarily through peripheral pathways .
220011	0	Corticoliberin	0,14	CRF	16,19	Corticoliberin	CRF	MESH:D003346	81648(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Corticoliberin -LRB- CRF -RRB- activity of the rat neurohypophysis .
11997017	0	Corticosteroid	0,14	IL-4	24,28	Corticosteroid	IL-4	CHEBI:50858	3565	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Corticosteroid inhibits IL-4 signaling through down-regulation of IL-4_receptor and STAT6 activity .
11316238	0	Corticosteroid	0,14	IgA_nephropathy	40,55	Corticosteroid	IgA nephropathy	CHEBI:50858	60498	Chemical	Gene	therapy|amod|START_ENTITY therapy|nmod|END_ENTITY	Corticosteroid therapy in patients with IgA_nephropathy and impaired_renal_function .
23787555	0	Corticosteroid	0,14	IgA_nephropathy	26,41	Corticosteroid	IgA nephropathy	CHEBI:50858	60498	Chemical	Gene	therapy|amod|START_ENTITY therapy|nmod|END_ENTITY	Corticosteroid therapy in IgA_nephropathy with minimal change-like lesions : a single-centre cohort study .
16643899	0	Corticosteroid	0,14	MMP-9	40,45	Corticosteroid	MMP-9	CHEBI:50858	17395(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Corticosteroid and doxycycline suppress MMP-9 and inflammatory cytokine expression , MAPK activation in the corneal epithelium in experimental dry_eye .
25413040	0	Corticosteroid	0,14	Occludin	36,44	Corticosteroid	Occludin	CHEBI:50858	100506658	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Corticosteroid Regulates Epithelial Occludin Expression in Nasal Polyps through a MKP-1-Dependent Pathway .
21239442	0	Corticosteroid	0,14	P-glycoprotein	29,43	Corticosteroid	P-glycoprotein	CHEBI:50858	5243	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Corticosteroid regulation of P-glycoprotein in the developing blood-brain barrier .
23114370	0	Corticosteroid	0,14	ST-11	35,40	Corticosteroid	ST-11	CHEBI:50858	8466	Chemical	Gene	therapy|amod|START_ENTITY therapy|nmod|END_ENTITY	Corticosteroid therapy in genotype ST-11 meningococcal_infections .
20237346	0	Corticosteroid	0,14	VEGF-A	30,36	Corticosteroid	VEGF-A	CHEBI:50858	22339(Tax:10090)	Chemical	Gene	suppression|amod|START_ENTITY suppression|nmod|END_ENTITY	Corticosteroid suppression of VEGF-A in infantile_hemangioma-derived stem cells .
17490617	0	Corticosteroid	0,14	heme_oxygenase-1	24,40	Corticosteroid	heme oxygenase-1	CHEBI:50858	3162	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|amod|END_ENTITY	Corticosteroid enhances heme_oxygenase-1 production by circulating monocytes by up-regulating hemoglobin_scavenger_receptor and amplifying the receptor-mediated uptake of hemoglobin-haptoglobin complex .
18650268	0	Corticosteroids	0,15	COX-2	23,28	Corticosteroids	COX-2	MESH:D000305	17709(Tax:10090)	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|compound|END_ENTITY	Corticosteroids induce COX-2 expression in cardiomyocytes : role of glucocorticoid receptor and C/EBP-beta .
18599619	0	Corticosteroids	0,15	cyclooxygenase_1	23,39	Corticosteroids	cyclooxygenase 1	MESH:D000305	5742	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|amod|END_ENTITY	Corticosteroids induce cyclooxygenase_1 expression in cardiomyocytes : role of glucocorticoid_receptor and Sp3_transcription_factor .
8703481	0	Corticosteroids	0,15	interleukin-1_receptor_antagonist	37,70	Corticosteroids	interleukin-1 receptor antagonist	MESH:D000305	3557	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|amod|END_ENTITY	Corticosteroids induce intracellular interleukin-1_receptor_antagonist type I expression by a human airway epithelial cell line .
17395587	0	Corticosteroids	0,15	interleukin-6	78,91	Corticosteroids	interleukin-6	MESH:D000305	3569	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	Corticosteroids and beta2 agonists differentially regulate rhinovirus-induced interleukin-6 via distinct Cis-acting elements .
4363642	0	Corticosterone	0,14	ACTH	30,34	Corticosterone	ACTH	MESH:D003345	5443	Chemical	Gene	suppression|amod|START_ENTITY suppression|nmod|secretion secretion|compound|END_ENTITY	Corticosterone suppression of ACTH secretion : actinomycin_D sensitive and insensitive components of the response .
10938578	0	Corticosterone	0,14	BDNF	26,30	Corticosterone	BDNF	MESH:D003345	24225(Tax:10116)	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|expression expression|amod|END_ENTITY	Corticosterone effects on BDNF mRNA expression in the rat hippocampus during morris water maze training .
10938581	0	Corticosterone	0,14	BDNF	26,30	Corticosterone	BDNF	MESH:D003345	24225(Tax:10116)	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|expression expression|compound|END_ENTITY	Corticosterone effects on BDNF expression in the hippocampus .
22244747	0	Corticosterone	0,14	BDNF	81,85	Corticosterone	BDNF	MESH:D003345	24225(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	Corticosterone reduces brain mitochondrial function and expression of mitofusin , BDNF in depression-like rodents regardless of exercise preconditioning .
9169859	0	Corticosterone	0,14	BDNF	39,43	Corticosterone	BDNF	MESH:D003345	24225(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|mRNA mRNA|amod|END_ENTITY	Corticosterone regulates expression of BDNF and trkB but not NT-3 and trkC mRNA in the rat hippocampus .
26915917	0	Corticosterone	53,67	Bcl-xL	27,33	Corticosterone	Bcl-xL	MESH:D003345	24888(Tax:10116)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|Expression Expression|compound|END_ENTITY	Differential Regulation of Bcl-xL Gene Expression by Corticosterone , Progesterone , and Retinoic_Acid .
16504399	0	Corticosterone	0,14	CCL2	39,43	Corticosterone	CCL2	MESH:D003345	24770(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Corticosterone regulates expression of CCL2 in the intact and chemically injured hippocampus .
8414172	0	Corticosterone	0,14	CRF	123,126	Corticosterone	CRF	MESH:D003345	81648(Tax:10116)	Chemical	Gene	response|amod|START_ENTITY independent|nsubj|response independent|dep|END_ENTITY	Corticosterone response to the serotonergic agonist D-fenfluramine may be independent from corticotropin-releasing_factor -LRB- CRF -RRB- .
8347826	0	Corticosterone	0,14	FGF-2	25,30	Corticosterone	FGF-2	MESH:D003345	54250(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Corticosterone increases FGF-2 -LRB- bFGF -RRB- immunoreactivity in the substantia nigra of the rat .
16473474	0	Corticosterone	0,14	GLT-1	75,80	Corticosterone	GLT-1	MESH:D003345	29482(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Corticosterone inhibits expression of the microglial glutamate_transporter GLT-1 in vitro .
1626640	0	Corticosterone	0,14	alcohol_dehydrogenase	33,54	Corticosterone	alcohol dehydrogenase	MESH:D003345	78959(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|mRNA mRNA|compound|END_ENTITY	Corticosterone induces rat liver alcohol_dehydrogenase mRNA but not enzyme protein or activity .
7554116	0	Corticosterone	0,14	angiotensin_II	41,55	Corticosterone	angiotensin II	MESH:D003345	24179(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|receptors receptors|amod|END_ENTITY	Corticosterone metabolism and effects on angiotensin_II receptors in vascular smooth muscle .
12359311	0	Corticosterone	0,14	bax	40,43	Corticosterone	bax	MESH:D003345	24887(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|levels levels|amod|END_ENTITY	Corticosterone differentially regulates bax , bcl-2 and bcl-x mRNA levels in the rat hippocampus .
8004437	0	Corticosterone	0,14	corticotropin-releasing_hormone	26,57	Corticosterone	corticotropin-releasing hormone	MESH:D003345	81648(Tax:10116)	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|mRNA mRNA|amod|END_ENTITY	Corticosterone effects on corticotropin-releasing_hormone mRNA in the central nucleus of the amygdala and the parvocellular region of the paraventricular nucleus of the hypothalamus .
7731495	0	Corticosterone	0,14	growth_hormone-releasing_factor	25,56	Corticosterone	growth hormone-releasing factor	MESH:D003345	29446(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Corticosterone modulates growth_hormone-releasing_factor and somatostatin in fetal rat hypothalamic cultures .
22610366	0	Corticosterone	0,14	neuropeptide_Y	43,57	Corticosterone	neuropeptide Y	MESH:D003345	4852	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Corticosterone regulates the expression of neuropeptide_Y and reelin in MLO-Y4 cells .
20070865	0	Corticosterone	0,14	norepinephrine_transporter	55,81	Corticosterone	norepinephrine transporter	MESH:D003345	6530	Chemical	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|nmod|cells cells|amod|END_ENTITY	Corticosterone up-regulates expression and function of norepinephrine_transporter in SK-N-BE -LRB- 2 -RRB- C cells .
24111919	0	Corticosterone	0,14	norepinephrine_transporter	57,83	Corticosterone	norepinephrine transporter	MESH:D003345	83511(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Corticosterone administration up-regulated expression of norepinephrine_transporter and dopamine_b-hydroxylase in rat locus coeruleus and its terminal regions .
2178253	0	Corticotropin	0,13	GAP-43	91,97	Corticotropin	GAP-43	MESH:D000324	2596	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|proteolysis proteolysis|nmod|END_ENTITY	Corticotropin -LRB- ACTH -RRB- inhibits the specific proteolysis of the neuronal phosphoprotein B-50 / GAP-43 .
11261504	0	Corticotropin	0,13	corticotropin-releasing_hormone	72,103	Corticotropin	corticotropin-releasing hormone	MESH:D000324	1392	Chemical	Gene	acts|nsubj|START_ENTITY acts|nmod|expression expression|amod|END_ENTITY	Corticotropin -LRB- ACTH -RRB- acts directly on amygdala neurons to down-regulate corticotropin-releasing_hormone gene expression .
2174200	0	Corticotropin	0,13	corticotropin-releasing_hormone	66,97	Corticotropin	corticotropin-releasing hormone	MESH:D000324	1392	Chemical	Gene	responses|compound|START_ENTITY responses|nmod|END_ENTITY	Corticotropin , cortisol and beta-endorphin responses to the human corticotropin-releasing_hormone during melancholia and after unilateral electroconvulsive therapy .
14767873	0	Cortisol	178,186	ACTH	226,230	Cortisol	ACTH	MESH:D006854	5443	Chemical	Gene	response|amod|START_ENTITY response|nmod|END_ENTITY	Circulating adrenocorticotropic_hormone -LRB- ACTH -RRB- and cortisol concentrations in normal , appropriate-for-gestational-age newborns versus those with sepsis and respiratory_distress : Cortisol response to low-dose and standard-dose ACTH tests .
16233969	0	Cortisol	0,8	ACTH	67,71	Cortisol	ACTH	MESH:D006854	403659(Tax:9615)	Chemical	Gene	treated|advmod|START_ENTITY treated|nsubj|concentrations concentrations|compound|END_ENTITY	Cortisol , aldosterone , cortisol precursor , androgen and endogenous ACTH concentrations in dogs with pituitary-dependant hyperadrenocorticism treated with trilostane .
23490274	0	Cortisol	0,8	ACTH	44,48	Cortisol	ACTH	MESH:D006854	5443	Chemical	Gene	hyporesponsiveness|amod|START_ENTITY hyporesponsiveness|nmod|test test|compound|END_ENTITY	Cortisol hyporesponsiveness to the low dose ACTH test is a frequent finding in a pediatric population with type_1_diabetes_mellitus .
23729816	0	Cortisol	0,8	ACTH	10,14	Cortisol	ACTH	MESH:D006854	5443	Chemical	Gene	START_ENTITY|dep|ratio ratio|amod|END_ENTITY	Cortisol : ACTH ratio to test for primary_hypoadrenalism : a pilot study .
23865937	0	Cortisol	0,8	ACTH	87,91	Cortisol	ACTH	MESH:D006854	5443	Chemical	Gene	secretion|amod|START_ENTITY discovered|nsubj|secretion discovered|advcl|responsive responsive|xcomp|END_ENTITY	Cortisol secretion from adrenal_adenomas discovered as incidentalomas is responsive to ACTH .
2561010	0	Cortisol	0,8	ACTH	10,14	Cortisol	ACTH	MESH:D006854	5443	Chemical	Gene	START_ENTITY|dobj|responses responses|compound|END_ENTITY	Cortisol , ACTH , prolactin and beta-endorphin responses to fenfluramine administration in major-depressed patients .
2561495	0	Cortisol	0,8	ACTH	33,37	Cortisol	ACTH	MESH:D006854	5443	Chemical	Gene	feedback|amod|START_ENTITY feedback|nmod|END_ENTITY	Cortisol feedback on ovine fetal ACTH secretion during the last fifth of gestation .
24760986	0	Cortisol	0,8	CXCR4	19,24	Cortisol	CXCR4	MESH:D006854	7852	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Cortisol increases CXCR4 expression but does not affect CD62L and CCR7 levels on specific T cell subsets in humans .
11399505	0	Cortisol	0,8	HSP90	19,24	Cortisol	HSP90	MESH:D006854	30591(Tax:7955)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|compound|END_ENTITY	Cortisol modulates HSP90 mRNA expression in primary cultures of trout hepatocytes .
8691098	0	Cortisol	0,8	IGF-I	19,24	Cortisol	IGF-I	MESH:D006854	3479	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|levels levels|amod|END_ENTITY	Cortisol decreases IGF-I mRNA levels in human osteoblast-like cells .
8094292	0	Cortisol	0,8	P-glycoprotein	65,79	Cortisol	P-glycoprotein	MESH:D006854	5243	Chemical	Gene	transported|nsubjpass|START_ENTITY transported|nmod|END_ENTITY	Cortisol is transported by the multidrug resistance gene product P-glycoprotein .
22918179	0	Cortisol	0,8	POMC	80,84	Cortisol	POMC	MESH:D006854	5443	Chemical	Gene	response|amod|START_ENTITY leads|nsubj|response leads|nmod|END_ENTITY	Cortisol response to waterborne 4-nonylphenol exposure leads to increased brain POMC and HSP70 mRNA expressions and reduced total antioxidant capacity in juvenile sole -LRB- Solea solea -RRB- .
12152842	0	Cortisol	0,8	arginine-vasopressin	21,41	Cortisol	arginine-vasopressin	MESH:D006854	551	Chemical	Gene	response|amod|START_ENTITY response|nmod|END_ENTITY	Cortisol response to arginine-vasopressin does not compare with cortisol response to insulin-hypoglycemia in pituitary_tumors .
1620969	0	Cortisol	0,8	corticosteroid_binding_globulin	29,60	Cortisol	corticosteroid binding globulin	MESH:D006854	490838(Tax:9615)	Chemical	Gene	capacity|amod|START_ENTITY capacity|nmod|END_ENTITY	Cortisol binding capacity of corticosteroid_binding_globulin in hyperadrenocorticoid and healthy dogs .
15546899	0	Cortisol	0,8	corticotropin-releasing_hormone	27,58	Cortisol	corticotropin-releasing hormone	MESH:D006854	1392	Chemical	Gene	START_ENTITY|advcl|ovine ovine|dobj|END_ENTITY	Cortisol response to ovine corticotropin-releasing_hormone in a model of pregnancy and parturition in euthymic women with and without a history of postpartum_depression .
2389623	0	Cortisol	0,8	corticotropin-releasing_hormone	92,123	Cortisol	corticotropin-releasing hormone	MESH:D006854	1392	Chemical	Gene	release|nsubj|START_ENTITY release|nmod|pigs pigs|nmod|administration administration|nmod|END_ENTITY	Cortisol release in pigs following peripheral and central administration of ovine and human corticotropin-releasing_hormone .
7494465	0	Cortisol	0,8	corticotropin_releasing_factor	22,52	Cortisol	corticotropin releasing factor	MESH:D006854	1392	Chemical	Gene	up-regulates|amod|START_ENTITY END_ENTITY|nsubj|up-regulates	Cortisol up-regulates corticotropin_releasing_factor gene expression in the fetal ovine brainstem at 0.70 gestation .
12450642	0	Cortisol	0,8	growth_hormone	37,51	Cortisol	growth hormone	MESH:D006854	2688	Chemical	Gene	modulation|amod|START_ENTITY modulation|nmod|release release|compound|END_ENTITY	Cortisol modulation of 5-HT-mediated growth_hormone release in recovered depressed patients .
5435293	0	Cortisol	0,8	growth_hormone	24,38	Cortisol	growth hormone	MESH:D006854	2688	Chemical	Gene	stimulation|amod|START_ENTITY stimulation|nmod|production production|amod|END_ENTITY	Cortisol stimulation of growth_hormone production by human pituitary tissue in culture .
5823301	0	Cortisol	0,8	growth_hormone	22,36	Cortisol	growth hormone	MESH:D006854	81668(Tax:10116)	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|synthesis synthesis|amod|END_ENTITY	Cortisol induction of growth_hormone synthesis in a clonal line of rat pituitary_tumor cells in culture .
6734516	0	Cortisol	0,8	growth_hormone	31,45	Cortisol	growth hormone	MESH:D006854	2688	Chemical	Gene	augments|nsubj|START_ENTITY augments|dobj|synthesis synthesis|nmod|END_ENTITY	Cortisol augments synthesis of growth_hormone , but does not alter synthesis of prolactin and proopiomelanocortin , in the 120 - to 125-day fetal ovine pituitary .
8071650	0	Cortisol	0,8	growth_hormone	67,81	Cortisol	growth hormone	MESH:D006854	81668(Tax:10116)	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Cortisol inhibition of growth_hormone-releasing hormone-stimulated growth_hormone release from cultured sheep pituitary cells .
10652957	0	Cortisol	0,8	hepatocyte_growth_factor	19,43	Cortisol	hepatocyte growth factor	MESH:D006854	3082	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|levels levels|compound|END_ENTITY	Cortisol decreases hepatocyte_growth_factor levels in human osteoblast-like cells .
20660036	0	Cortisol	0,8	insulin	39,46	Cortisol	insulin	MESH:D006854	3630	Chemical	Gene	associated|nsubjpass|START_ENTITY associated|nmod|sensitivity sensitivity|compound|END_ENTITY	Cortisol is negatively associated with insulin sensitivity in overweight Latino youth .
21175444	0	Cortisol	0,8	insulin	43,50	Cortisol	insulin	MESH:D006854	3630	Chemical	Gene	response|amod|START_ENTITY response|nmod|infusions infusions|compound|END_ENTITY	Cortisol response to individualised graded insulin infusions : a reproducible biomarker for CNS compounds inhibiting HPA activation .
11607172	0	Cortisol	0,8	prolactin	25,34	Cortisol	prolactin	MESH:D006854	5617	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|release release|compound|END_ENTITY	Cortisol rapidly reduces prolactin release and cAMP and 45Ca2 + accumulation in the cichlid fish pituitary in vitro .
14711886	0	Cortisol	0,8	renin	28,33	Cortisol	renin	MESH:D006854	443310(Tax:9940)	Chemical	Gene	infusion|amod|START_ENTITY decreases|nsubj|infusion decreases|dobj|EP2 EP2|amod|END_ENTITY	Cortisol infusion decreases renin , but not PGHS-2 , EP2 , or EP4 mRNA expression in the kidney of the fetal sheep at days 109-116 .
8419910	0	Cortivazol	0,10	glucocorticoid_receptor	21,44	Cortivazol	glucocorticoid receptor	MESH:C005924	101844805	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Cortivazol increases glucocorticoid_receptor expression and inhibits growth of hamster pancreatic_cancer -LRB- H2T -RRB- in vivo .
21826053	0	Corydaline	0,10	cytochrome_P450	29,44	Corydaline	cytochrome P450	MESH:C452799	4051	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Corydaline inhibits multiple cytochrome_P450 and UDP-glucuronosyltransferase enzyme activities in human liver microsomes .
9731289	1	Corynebacterium	39,54	N-acetyl-beta-glucosaminidase	60,89	Corynebacterium	N-acetyl-beta-glucosaminidase	null	10724	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	nov. , a Corynebacterium with N-acetyl-beta-glucosaminidase activity from human clinical specimens .
18811972	0	Corynebacterium_ammoniagenes	43,71	FAD_synthetase	23,37	Corynebacterium ammoniagenes	FAD synthetase	null	80308	Chemical	Gene	analysis|nmod|START_ENTITY analysis|nmod|END_ENTITY	Structural analysis of FAD_synthetase from Corynebacterium_ammoniagenes .
21467650	0	Costunolide	0,11	Akt	97,100	Costunolide	Akt	MESH:C002602	207	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|inhibition inhibition|nmod|END_ENTITY	Costunolide induces apoptosis in human endometriotic cells through inhibition of the prosurvival Akt and nuclear factor kappa B signaling pathway .
27078502	0	Costunolide	0,11	P53	74,77	Costunolide	P53	MESH:C002602	7157	Chemical	Gene	Generation|compound|START_ENTITY Generation|nmod|END_ENTITY	Costunolide Induces Apoptosis through Generation of ROS and Activation of P53 in Human Esophageal Cancer Eca-109 Cells .
14672714	0	Costunolide	0,11	interleukin-1beta	21,38	Costunolide	interleukin-1beta	MESH:C002602	16176(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Costunolide inhibits interleukin-1beta expression by down-regulation of AP-1 and MAPK activity in LPS-stimulated RAW 264.7 cells .
18210237	0	Costunolide	0,11	tumor_necrosis_factor-alpha	35,62	Costunolide	tumor necrosis factor-alpha	MESH:C002602	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|nmod|END_ENTITY	Costunolide inhibits production of tumor_necrosis_factor-alpha and interleukin-6 by inducing heme_oxygenase-1 in RAW264 .7 macrophages .
19954971	0	Coumarins	0,9	17beta-hydroxysteroid_dehydrogenase_type_3	19,61	Coumarins	17beta-hydroxysteroid dehydrogenase type 3	MESH:D003374	3293	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Coumarins as novel 17beta-hydroxysteroid_dehydrogenase_type_3 inhibitors for potential treatment of prostate_cancer .
27053426	1	Coumarins	63,72	Thrombin	116,124	Coumarins	Thrombin	MESH:D003374	2147	Chemical	Gene	Regulation|compound|START_ENTITY Regulation|nmod|END_ENTITY	Sulfated Coumarins Induce Regulation , not just Inhibition , of Thrombin .
11543689	0	Coumarins	0,9	acetylcholinesterase	44,64	Coumarins	acetylcholinesterase	MESH:D003374	43	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|inhibitors inhibitors|nmod|END_ENTITY	Coumarins derivatives as dual inhibitors of acetylcholinesterase and monoamine oxidase .
26991852	0	Coumestrol	23,33	AKT	77,80	Coumestrol	AKT	MESH:D003375	100126861(Tax:9823)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Stimulatory Effects of Coumestrol on Embryonic and Fetal Development through AKT and ERK1/2 MAPK Signal Transduction .
24712520	0	Coumestrol	0,10	Sirt1	58,63	Coumestrol	Sirt1	MESH:D003375	23411	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|activating activating|dobj|END_ENTITY	Coumestrol induces mitochondrial biogenesis by activating Sirt1 in cultured skeletal muscle cells .
24768446	0	Coumestrol	0,10	hypoxia_inducible_factor_1a	22,49	Coumestrol	hypoxia inducible factor 1a	MESH:D003375	3091	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	Coumestrol suppresses hypoxia_inducible_factor_1a by inhibiting ROS mediated sphingosine_kinase_1 in hypoxic_PC-3_prostate_cancer cells .
18160770	0	Coumestrol	0,10	intestinal_alkaline_phosphatase	21,52	Coumestrol	intestinal alkaline phosphatase	MESH:D003375	11648(Tax:10090)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|activity activity|amod|END_ENTITY	Coumestrol decreases intestinal_alkaline_phosphatase activity in post-delivery mice but does not affect vitamin_D_receptor and calcium channels in post-delivery and neonatal mice .
17325651	0	Coxib	100,105	cyclooxygenase-2	72,88	Coxib	cyclooxygenase-2	null	29527(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Surface phospholipids in gastric_injury and protection when a selective cyclooxygenase-2 inhibitor -LRB- Coxib -RRB- is used in combination with aspirin .
21724179	0	CpG	41,44	B-cell_activating_factor	0,24	CpG	B-cell activating factor	null	504507(Tax:9913)	Chemical	Gene	activation|compound|START_ENTITY promotes|dobj|activation promotes|nsubj|END_ENTITY	B-cell_activating_factor -LRB- BAFF -RRB- promotes CpG ODN-induced B cell activation and proliferation .
9778046	0	CpG	34,37	BRCA1	28,33	CpG	BRCA1	null	672	Chemical	Gene	promoter|compound|START_ENTITY promoter|compound|END_ENTITY	Aberrant methylation of the BRCA1 CpG island promoter is associated with decreased BRCA1 mRNA in sporadic_breast_cancer cells .
15685542	0	CpG	10,13	CD27	46,50	CpG	CD27	null	939	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|nmod|END_ENTITY	Bacterial CpG induces hyper-IgM production in CD27 -LRB- + -RRB- memory B cells in primary_biliary_cirrhosis .
12203775	0	CpG	52,55	E-cadherin	26,36	CpG	E-cadherin	null	999	Chemical	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Epigenetic control of the E-cadherin gene -LRB- CDH1 -RRB- by CpG methylation in colectomy samples of patients with ulcerative_colitis .
16732935	0	CpG	39,42	E-cadherin	73,83	CpG	E-cadherin	null	999	Chemical	Gene	status|compound|START_ENTITY status|nmod|END_ENTITY	-LSB- Studies on gene expression and the 5 ' CpG islands methylation status of E-cadherin in acute_myeloid_leukemia -RSB- .
7543680	0	CpG	56,59	E-cadherin	17,27	CpG	E-cadherin	null	999	Chemical	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas .
11971021	5	CpG	885,888	ERK	902,905	CpG	ERK	null	26413(Tax:10090)	Chemical	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	In contrast , CpG DNA-mediated ERK activation was shown to suppress IL-12 production , but to be essential for the CpG DNA-induced IL-10 production .
26812280	0	CpG	36,39	HTR2A	79,84	CpG	HTR2A	null	3356	Chemical	Gene	Polymorphisms|compound|START_ENTITY Polymorphisms|nmod|Gene Gene|compound|END_ENTITY	Interaction between Methylation and CpG Single-Nucleotide Polymorphisms in the HTR2A Gene : Association Analysis with Suicide Attempt in Schizophrenia .
11884451	0	CpG	66,69	IFN-gamma	44,53	CpG	IFN-gamma	null	3458	Chemical	Gene	promoter|nmod|START_ENTITY promoter|amod|END_ENTITY	Differential patterns of methylation of the IFN-gamma promoter at CpG and non-CpG sites underlie differences in IFN-gamma gene expression between human neonatal and adult CD45RO - T cells .
12432235	0	CpG	0,3	IL-12_p40	16,25	CpG	IL-12 p40	null	16160(Tax:10090)	Chemical	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	CpG DNA induced IL-12_p40 gene activation is independent of STAT1 activation or production of interferon_consensus_sequence_binding_protein .
10602032	0	CpG	56,59	IL-6	105,109	CpG	IL-6	null	3569	Chemical	Gene	START_ENTITY|dobj|regulation regulation|nmod|expression expression|compound|END_ENTITY	Positive and negative regulatory elements contribute to CpG oligonucleotide-mediated regulation of human IL-6 gene expression .
23874506	0	CpG	0,3	IL2RA	35,40	CpG	IL2RA	null	3559	Chemical	Gene	START_ENTITY|nmod|promoter promoter|compound|END_ENTITY	CpG methylation changes within the IL2RA promoter in type 1 diabetes of childhood onset .
23000019	0	CpG	9,12	Lyn	43,46	CpG	Lyn	null	100152890(Tax:9823)	Chemical	Gene	status|compound|START_ENTITY status|nmod|END_ENTITY	Promoter CpG methylation status in porcine Lyn is associated with its expression levels .
23358417	0	CpG	132,135	MagohB	125,131	CpG	MagohB	null	66441(Tax:10090)	Chemical	Gene	promoter|compound|START_ENTITY promoter|compound|END_ENTITY	The histone methyltransferase KMT2B is required for RNA polymerase II association and protection from DNA methylation at the MagohB CpG island promoter .
26074794	4	CpG	665,668	NR3C1	659,664	CpG	NR3C1	null	2908	Chemical	Gene	sites|compound|START_ENTITY sites|compound|END_ENTITY	A factor analysis of NR3C1 CpG sites revealed two factors : one for CpG sites 1-4 and the other for sites 5-13 .
9315639	0	CpG	26,29	O6-methylguanine_DNA_methyltransferase	54,92	CpG	O6-methylguanine DNA methyltransferase	null	4255	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Aberrant silencing of the CpG island-containing human O6-methylguanine_DNA_methyltransferase gene is associated with the loss of nucleosome-like positioning .
22296786	0	CpG	91,94	P39	65,68	CpG	P39	null	12570(Tax:10090)	Chemical	Gene	protein|nmod|START_ENTITY protein|compound|END_ENTITY	Efficacy evaluation of live Escherichia_coli expression Brucella P39 protein combined with CpG oligodeoxynucleotides vaccine against Brucella_melitensis 16M , in BALB/c mice .
23722468	0	CpG	48,51	Somatostatin_receptor_1	0,23	CpG	Somatostatin receptor 1	null	6751	Chemical	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	Somatostatin_receptor_1 , a novel EBV-associated CpG hypermethylated gene , contributes to the pathogenesis of EBV-associated gastric_cancer .
12766768	0	CpG	0,3	T-bet	21,26	CpG	T-bet	null	57765(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	CpG directly induces T-bet expression and inhibits IgG1 and IgE switching in B cells .
20498358	0	CpG	27,30	TLR21	8,13	CpG	TLR21	null	415623(Tax:9031)	Chemical	Gene	receptor|compound|START_ENTITY receptor|nsubj|END_ENTITY	Chicken TLR21 is an innate CpG DNA receptor distinct from mammalian TLR9 .
16421948	0	CpG	0,3	TLR9	36,40	CpG	TLR9	null	54106	Chemical	Gene	START_ENTITY|dobj|activation activation|nmod|END_ENTITY	CpG motif-independent activation of TLR9 upon endosomal translocation of `` natural '' phosphodiester DNA .
21766476	0	CpG	63,66	TLR9	81,85	CpG	TLR9	null	81897(Tax:10090)	Chemical	Gene	binding|nmod|START_ENTITY binding|nmod|END_ENTITY	Competition by inhibitory oligonucleotides prevents binding of CpG to C-terminal TLR9 .
11971021	0	CpG	181,184	Th1	198,201	CpG	Th1	null	57314(Tax:10090)	Chemical	Gene	response|compound|START_ENTITY response|compound|END_ENTITY	Role of mitogen-activated protein kinases in CpG DNA-mediated IL-10 and IL-12 production : central role of extracellular_signal-regulated_kinase in the negative feedback loop of the CpG DNA-mediated Th1 response .
19034349	0	CpG	37,40	Toll-like_receptor_9	0,20	CpG	Toll-like receptor 9	null	54106	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Toll-like_receptor_9 activation with CpG oligodeoxynucleotides for asthma therapy .
9758623	0	CpG	31,34	VIII	55,59	CpG	VIII	null	1351	Chemical	Gene	sites|compound|START_ENTITY sites|nmod|END_ENTITY	Methylation levels at selected CpG sites in the factor VIII and FGFR3 genes , in mature female and male germ cells : implications for male-driven evolution .
3219291	0	CpG	20,23	coagulation_factor-IX	40,61	CpG	coagulation factor-IX	null	2158	Chemical	Gene	mutation|compound|START_ENTITY mutation|nmod|gene gene|amod|END_ENTITY	Identification of a CpG mutation in the coagulation_factor-IX gene by analysis of amplified DNA sequences .
22524805	0	CpG	0,3	estrogen_receptor_alpha	34,57	CpG	estrogen receptor alpha	null	2099	Chemical	Gene	profile|compound|START_ENTITY profile|nmod|END_ENTITY	CpG island methylation profile of estrogen_receptor_alpha in Iranian females with triple negative or non-triple negative breast_cancer : new marker of poor prognosis .
21870982	0	CpG	0,3	hexamerin_110	23,36	CpG	hexamerin 110	null	551648(Tax:7460)	Chemical	Gene	START_ENTITY|nmod|gene gene|amod|END_ENTITY	CpG methylation in the hexamerin_110 gene in the European honeybee , Apis_mellifera .
7969137	0	CpG	0,3	hypoxanthine_phosphoribosyltransferase	77,115	CpG	hypoxanthine phosphoribosyltransferase	null	3251	Chemical	Gene	START_ENTITY|nmod|gene gene|amod|END_ENTITY	CpG island promoter region methylation patterns of the inactive-X-chromosome hypoxanthine_phosphoribosyltransferase -LRB- Hprt -RRB- gene .
9654078	0	CpG	66,69	hypoxia-inducible_factor-1	87,113	CpG	hypoxia-inducible factor-1	null	3091	Chemical	Gene	site|compound|START_ENTITY site|amod|END_ENTITY	Oxygen-regulated erythropoietin gene expression is dependent on a CpG methylation-free hypoxia-inducible_factor-1 DNA-binding site .
23331101	0	CpG	0,3	matrix_metalloproteinase-13	16,43	CpG	matrix metalloproteinase-13	null	17386(Tax:10090)	Chemical	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	CpG ODN-induced matrix_metalloproteinase-13 expression is mediated via activation of the ERK and NF-kB signalling pathways in odontoblast cells .
26524015	0	CpG	25,28	miR-34b	58,65	CpG	miR-34b	null	407041	Chemical	Gene	Status|compound|START_ENTITY Status|nmod|END_ENTITY	-LSB- Expression and Promoter CpG Island Methylation Status of miR-34b in Leukemia Cell Lines and Their Clinical Significance -RSB- .
11602627	0	CpG	38,41	p15	59,62	CpG	p15	null	1030	Chemical	Gene	region|compound|START_ENTITY region|nmod|END_ENTITY	Dynamic DNA methylation change in the CpG island region of p15 during human myeloid development .
10357792	0	CpG	118,121	p53	135,138	CpG	p53	null	7157	Chemical	Gene	sites|compound|START_ENTITY sites|nmod|gene gene|compound|END_ENTITY	Use of UvrABC nuclease to quantify benzo -LSB- a -RSB- pyrene_diol_epoxide-DNA adduct formation at methylated versus unmethylated CpG sites in the p53 gene .
7731703	0	CpG	47,50	p53	64,67	CpG	p53	null	7157	Chemical	Gene	sites|compound|START_ENTITY sites|nmod|gene gene|compound|END_ENTITY	Complete and tissue-independent methylation of CpG sites in the p53 gene : implications for mutations in human cancers .
25071010	0	CpG	65,68	p73	34,37	CpG	p73	null	7161	Chemical	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Transcriptional regulation of the p73 gene by Nrf-2 and promoter CpG methylation in human breast_cancer .
16952134	0	CpG	91,94	toll-like_receptor_9	95,115	CpG	toll-like receptor 9	null	54106	Chemical	Gene	agonists|compound|START_ENTITY agonists|amod|END_ENTITY	Structure-activity relationship studies on the immune stimulatory effects of base-modified CpG toll-like_receptor_9 agonists .
26158860	0	CpG-685	25,32	interleukin-21_receptor	56,79	CpG-685	interleukin-21 receptor	null	50615	Chemical	Gene	upregulates|amod|START_ENTITY upregulates|amod|END_ENTITY	CpG oligodeoxynucleotide CpG-685 upregulates functional interleukin-21_receptor on chronic_lymphocytic_leukemia B cells through an NF-kB mediated pathway .
15640365	6	CpG-ODN	1172,1179	CD40	1135,1139	CpG-ODN	TLR9	MESH:C408982	81897(Tax:10090)	Chemical	Gene	response|nmod|START_ENTITY expression|nmod|response expression|nmod|END_ENTITY	Consistent with the receptor expression , AMs showed no sensitivity to CpG-ODN , whereas other macrophage populations secreted tumor_necrosis_factor_alpha , interleukin 12 p40 , and interleukin_6 , and enhanced expression of CD40 , CD80 , and CD86 , in response to CpG-ODN .
23533581	0	CpG-ODN	58,65	DNA-PKcs	15,23	CpG-ODN	DNA-PKcs	MESH:C408982	5591	Chemical	Gene	response|nmod|START_ENTITY END_ENTITY|nmod|response	Involvement of DNA-PKcs in the IL-6 and IL-12 response to CpG-ODN is mediated by its interaction with TRAF6 in dendritic cells .
25922914	0	CpG-ODN	115,122	IFA	128,131	CpG-ODN	IFA	MESH:C408982	111654(Tax:10090)	Chemical	Gene	treatment|compound|START_ENTITY treatment|compound|END_ENTITY	Expansion of myeloid-derived suppressor cells with arginase activity lasts longer in aged than in young mice after CpG-ODN plus IFA treatment .
23533581	0	CpG-ODN	58,65	IL-6	31,35	CpG-ODN	IL-6	MESH:C408982	3569	Chemical	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Involvement of DNA-PKcs in the IL-6 and IL-12 response to CpG-ODN is mediated by its interaction with TRAF6 in dendritic cells .
18304423	0	CpG-ODN	12,19	NF-kappa_B	87,97	CpG-ODN	NF-kappa B	MESH:C408982	18033(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of CpG-ODN combined with HBsAg on the phenotype , function and the activity of NF-kappa_B and AP-1 of monocyte-derived dendritic cells in chronic_hepatitis_B patients -RSB- .
19573862	0	CpG-ODN	67,74	TLR9	21,25	CpG-ODN	TLR9	MESH:C408982	54106	Chemical	Gene	predicts|nmod|START_ENTITY predicts|nsubj|level level|nmod|mRNA mRNA|compound|END_ENTITY	A threshold level of TLR9 mRNA predicts cellular responsiveness to CpG-ODN in haematological and non-haematological tumour cell lines .
21296339	0	CpG-ODN	133,140	TLR9	120,124	CpG-ODN	TLR9	MESH:C408982	54106	Chemical	Gene	ligand|appos|START_ENTITY ligand|nummod|END_ENTITY	B cells from common variable immunodeficiency patients fail to differentiate to antibody secreting cells in response to TLR9 ligand -LRB- CpG-ODN -RRB- or anti-CD40 + IL21 .
22085974	0	CpG-ODN	12,19	TLR9	0,4	CpG-ODN	TLR9	MESH:C408982	81897(Tax:10090)	Chemical	Gene	applied|nsubj|START_ENTITY ligand|ccomp|applied ligand|nsubj|END_ENTITY	TLR9 ligand CpG-ODN applied to the injured mouse cornea_elicits_retinal_inflammation .
22917564	0	CpG-ODN	0,7	TLR9	13,17	CpG-ODN	TLR9	MESH:C408982	81897(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	CpG-ODN , the TLR9 agonist , attenuates myocardial_ischemia / reperfusion injury : involving activation of PI3K/Akt signaling .
24721797	0	CpG-ODN	17,24	TLR9	4,8	CpG-ODN	TLR9	MESH:C408982	81897(Tax:10090)	Chemical	Gene	ligand|appos|START_ENTITY ligand|compound|END_ENTITY	The TLR9 ligand , CpG-ODN , induces protection against cerebral_ischemia / reperfusion injury via activation of PI3K/Akt signaling .
20725994	0	CpG-ODN	0,7	VEGF	33,37	CpG-ODN	VEGF	MESH:C408982	22339(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|release release|nmod|END_ENTITY	CpG-ODN increases the release of VEGF in a mouse model of lung_carcinoma .
8566964	0	CpG_dinucleotides	0,17	hMSH2	25,30	CpG dinucleotides	hMSH2	null	4436	Chemical	Gene	START_ENTITY|nmod|genes genes|amod|END_ENTITY	CpG_dinucleotides in the hMSH2 and hMLH1 genes are hotspots for HNPCC mutations .
7614480	0	CpG_dinucleotides	20,37	p53	45,48	CpG dinucleotides	p53	null	7157	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Base transitions at CpG_dinucleotides in the p53 gene are common in esophageal_adenocarcinoma .
10222348	0	CpG_dinucleotides	97,114	steroid_21-hydroxylase	133,155	CpG dinucleotides	steroid 21-hydroxylase	null	1589	Chemical	Gene	START_ENTITY|nmod|gene gene|amod|END_ENTITY	Single-nucleotide polymorphisms in intron 2 of CYP21P : evidence for a higher rate of mutation at CpG_dinucleotides in the functional steroid_21-hydroxylase gene and application to segregation analysis in congenital_adrenal_hyperplasia .
10078935	0	CpGs	24,28	O6-methylguanine-DNA_methyltransferase	42,80	CpGs	O6-methylguanine-DNA methyltransferase	null	4255	Chemical	Gene	START_ENTITY|nmod|region region|compound|END_ENTITY	Methylation of selected CpGs in the human O6-methylguanine-DNA_methyltransferase promoter region as a marker of gene silencing .
22117551	0	CpdA	63,67	glucocorticoid_receptor	32,55	CpdA	glucocorticoid receptor	null	2908	Chemical	Gene	ligand|dobj|START_ENTITY ligand|nsubj|effect effect|nmod|END_ENTITY	Antitumor effect of non-steroid glucocorticoid_receptor ligand CpdA on leukemia cell lines CEM and K562 .
22644605	11	Cr	1490,1492	SLC6A8	1483,1489	Cr	SLC6A8	null	6535	Chemical	Gene	properties|compound|START_ENTITY properties|compound|END_ENTITY	Although the mutations altered various domains of SLC6A8 Cr uptake and electrogenic properties were completely inhibited and could not be dissociated .
15892577	0	Cr	24,26	nitric_oxide_synthase	34,55	Cr	nitric oxide synthase	null	4842	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Reductive activation of Cr -LRB- Vi -RRB- by nitric_oxide_synthase .
1648096	0	CrATP	15,20	ATPase	81,87	CrATP	ATPase	MESH:D000255	1769	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of CrATP with the phosphorylation site of the sarcoplasmic reticulum ATPase .
26692374	0	CrB4	62,66	FeB4	86,90	CrB4	FeB4	null	84059	Chemical	Gene	START_ENTITY|nmod|comparison comparison|nmod|END_ENTITY	Structural variety beyond appearance : high-pressure phases of CrB4 in comparison with FeB4 .
24425244	0	Crassulacean_acid	21,38	CO2	13,16	Crassulacean acid	CO2	null	717	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	Recycling of CO2 via Crassulacean_acid metabolism in the rock outcrop succulent Sedum pulchellum Michx .
7375199	0	Creatine	1,9	CPK	18,21	Creatine	CPK	MESH:D003401	5286	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|dobj|END_ENTITY	-LSB- Creatine kinase -LRB- CPK -RRB- in congenital_hypothyroidism -RSB- .
25206338	0	Creatine	0,8	SLC6A8	22,28	Creatine	SLC6A8	MESH:D003401	102857(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY display|nsubj|transporter display|dep|END_ENTITY	Creatine transporter -LRB- SLC6A8 -RRB- knockout mice display an increased capacity for in vitro creatine biosynthesis in skeletal muscle .
21249153	0	Creatine	0,8	Slc6a8	27,33	Creatine	Slc6a8	MESH:D003401	102857(Tax:10090)	Chemical	Gene	transporter|amod|START_ENTITY transporter|dep|CrT CrT|dep|END_ENTITY	Creatine transporter -LRB- CrT ; Slc6a8 -RRB- knockout mice as a model of human CrT_deficiency .
17347380	0	Creatine	0,8	guanidinoacetate_methyltransferase	61,95	Creatine	guanidinoacetate methyltransferase	MESH:D003401	14431(Tax:10090)	Chemical	Gene	uptake|nsubj|START_ENTITY uptake|nmod|muscle muscle|nmod|mice mice|acl|lacking lacking|dobj|END_ENTITY	Creatine uptake in brain and skeletal muscle of mice lacking guanidinoacetate_methyltransferase assessed by magnetic resonance spectroscopy .
8813986	0	Creatine	0,8	guanidinoacetate_methyltransferase	32,66	Creatine	guanidinoacetate methyltransferase	MESH:D003401	2593	Chemical	Gene	START_ENTITY|nmod|deficiency deficiency|amod|END_ENTITY	Creatine replacement therapy in guanidinoacetate_methyltransferase deficiency , a novel inborn_error_of_metabolism .
25013643	0	Creatinine	81,91	Neutrophil_Gelatinase-associated_Lipocalin	20,62	Creatinine	Neutrophil Gelatinase-associated Lipocalin	MESH:D003404	3934	Chemical	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|END_ENTITY	Comparison of Serum Neutrophil_Gelatinase-associated_Lipocalin -LRB- NGAL -RRB- with Serum Creatinine in Prediction of Kidney Recovery after Renal Transplantation .
26174458	0	Creatinine	61,71	Neutrophil_Gelatinase-associated_Lipocalin	15,57	Creatinine	Neutrophil Gelatinase-associated Lipocalin	MESH:D003404	3934	Chemical	Gene	Ratio|acl|START_ENTITY Ratio|nmod|END_ENTITY	Urine Ratio of Neutrophil_Gelatinase-associated_Lipocalin to Creatinine as a Marker for Early Detection of Cisplatin-associated Nephrotoxicity .
26096867	0	Creatinine	52,62	Neutrophil_Gelatinase_Associated_Lipocalin	6,48	Creatinine	Neutrophil Gelatinase Associated Lipocalin	MESH:D003404	3934	Chemical	Gene	Ratio|compound|START_ENTITY END_ENTITY|nmod|Ratio	Urine Neutrophil_Gelatinase_Associated_Lipocalin to Creatinine Ratio : A Novel Index for Steroid Response in Idiopathic_Nephrotic_Syndrome .
24227820	0	Crenolanib	0,10	FLT3	36,40	Crenolanib	FLT3	MESH:C577197	2322	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Crenolanib is a potent inhibitor of FLT3 with activity against resistance-conferring point mutants .
25328409	0	Crenolanib	0,10	PDGFR	14,19	Crenolanib	PDGFR	MESH:C577197	5159	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Crenolanib , a PDGFR inhibitor , suppresses lung_cancer cell proliferation and inhibits tumor growth in vivo .
21838707	0	Crizotinib	65,75	ALK	11,14	Crizotinib	ALK	MESH:C551994	238	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubj|mutations mutations|compound|END_ENTITY	Activating ALK mutations found in neuroblastoma are inhibited by Crizotinib and NVP-TAE684 .
24885803	0	Crizotinib	216,226	ALK	0,3	Crizotinib	ALK	MESH:C551994	238	Chemical	Gene	Treatment|compound|START_ENTITY Eligible|nmod|Treatment Screening|nmod|Eligible Hybridization|nmod|Screening Comparison|acl:relcl|Hybridization Rearrangement|dep|Comparison Rearrangement|compound|END_ENTITY	ALK Rearrangement in a Large Series of Consecutive Non-Small_Cell_Lung_Cancers : Comparison Between a New Immunohistochemical Approach and Fluorescence In Situ Hybridization for the Screening of Patients Eligible for Crizotinib Treatment .
25193856	0	Crizotinib	0,10	ALK	52,55	Crizotinib	ALK	MESH:C551994	11682(Tax:10090)	Chemical	Gene	exhibits|nsubj|START_ENTITY exhibits|advcl|targeting targeting|advcl|signaling signaling|nsubj|END_ENTITY	Crizotinib exhibits antitumor activity by targeting ALK signaling not c-MET in pancreatic_cancer .
25322323	0	Crizotinib	46,56	ALK	0,3	Crizotinib	ALK	MESH:C551994	238	Chemical	Gene	Inhibitors|dep|START_ENTITY Inhibitors|compound|END_ENTITY	ALK Inhibitors in Non-Small_Cell_Lung_Cancer : Crizotinib and Beyond .
25326243	0	Crizotinib	0,10	ALK	80,83	Crizotinib	ALK	MESH:C551994	266802(Tax:10116)	Chemical	Gene	Reduces|nsubj|START_ENTITY Reduces|nmod|Independent Independent|nmod|Inhibition Inhibition|compound|END_ENTITY	Crizotinib Reduces the Rate of Dark Adaptation in the Rat Retina Independent of ALK Inhibition .
25393798	0	Crizotinib	71,81	ALK	36,39	Crizotinib	ALK	MESH:C551994	238	Chemical	Gene	confer|nmod|START_ENTITY confer|nsubj|mutations mutations|nmod|I1171 I1171|nmod|gene gene|compound|END_ENTITY	Secondary mutations at I1171 in the ALK gene confer resistance to both Crizotinib and Alectinib .
25520569	0	Crizotinib	86,96	ALK	23,26	Crizotinib	ALK	MESH:C551994	238	Chemical	Gene	Therapy|compound|START_ENTITY Eligibility|nmod|Therapy FISH|nmod|Eligibility Testing|nmod|FISH Testing|compound|END_ENTITY	Micro-cost Analysis of ALK Rearrangement Testing by FISH to Determine Eligibility for Crizotinib Therapy in NSCLC : Implications for Cost Effectiveness of Testing and Treatment .
25676398	0	Crizotinib	98,108	ALK	28,31	Crizotinib	ALK	MESH:C551994	238	Chemical	Gene	-RSB-|compound|START_ENTITY Treatment|nmod|-RSB- Treatment|nmod|Non-small_Cell_Lung_Cancer Non-small_Cell_Lung_Cancer|compound|END_ENTITY	-LSB- Treatment of Patients with ALK Gene Rearranged Non-small_Cell_Lung_Cancer after Resistance to Crizotinib . -RSB-
25676401	0	Crizotinib	1,11	ALK	57,60	Crizotinib	ALK	MESH:C551994	238	Chemical	Gene	Treatment|compound|START_ENTITY Treatment|nmod|Gene Gene|compound|END_ENTITY	-LSB- Crizotinib Treatment in a Lung_Adenocarcinoma Harboring ALK Fusion Gene with Bone_Marrow_Metastasis : Case Report and Literature Review . -RSB-
25899913	0	Crizotinib	10,20	ALK	58,61	Crizotinib	ALK	MESH:C551994	238	Chemical	Gene	schedule|compound|START_ENTITY schedule|nmod|patient patient|nmod|END_ENTITY	Effective Crizotinib schedule for an elderly patient with ALK rearranged non-small-cell_lung_cancer : a case report .
26001146	0	Crizotinib	74,84	ALK	43,46	Crizotinib	ALK	MESH:C551994	238	Chemical	Gene	Metastases|nmod|START_ENTITY Metastases|nmod|Patient Patient|compound|END_ENTITY	Diffuse Hemorrhagic_Brain Metastases in an ALK Fusion Positive Patient on Crizotinib .
26001146	0	Crizotinib	74,84	ALK	43,46	Crizotinib	ALK	MESH:C551994	238	Chemical	Gene	Metastases|nmod|START_ENTITY Metastases|nmod|Patient Patient|compound|END_ENTITY	Diffuse Hemorrhagic_Brain Metastases in an ALK Fusion Positive Patient on Crizotinib .
26001147	0	Crizotinib	97,107	ALK	34,37	Crizotinib	ALK	MESH:C551994	238	Chemical	Gene	Responds|nmod|START_ENTITY Responds|nsubj|BIRC6-ALK BIRC6-ALK|appos|Gene Gene|nmod|Lung_Adenocarcinoma Lung_Adenocarcinoma|compound|END_ENTITY	BIRC6-ALK , a Novel Fusion Gene in ALK Break-Apart FISH-Negative Lung_Adenocarcinoma , Responds to Crizotinib .
26001147	0	Crizotinib	97,107	ALK	34,37	Crizotinib	ALK	MESH:C551994	238	Chemical	Gene	Responds|nmod|START_ENTITY Responds|nsubj|BIRC6-ALK BIRC6-ALK|appos|Gene Gene|nmod|Lung_Adenocarcinoma Lung_Adenocarcinoma|compound|END_ENTITY	BIRC6-ALK , a Novel Fusion Gene in ALK Break-Apart FISH-Negative Lung_Adenocarcinoma , Responds to Crizotinib .
26568289	1	Crizotinib	280,290	ALK	229,232	Crizotinib	ALK	MESH:C551994	238	Chemical	Gene	development|nmod|START_ENTITY revolutionized|nmod|development revolutionized|nsubjpass|UNASSIGNED UNASSIGNED|appos|END_ENTITY	UNASSIGNED : The treatment of patients with advanced non-small_cell_lung_cancer -LRB- NSCLC -RRB- harboring chromosomal rearrangements of anaplastic_lymphoma_kinase -LRB- ALK -RRB- has been revolutionized by the development of Crizotinib , a small molecule inhibitor of ALK , ROS1 , and MET .
26698910	0	Crizotinib	19,29	ALK	48,51	Crizotinib	ALK	MESH:C551994	238	Chemical	Gene	Resensitization|nmod|START_ENTITY Resensitization|nmod|L1198F L1198F|compound|END_ENTITY	Resensitization to Crizotinib by the Lorlatinib ALK Resistance Mutation L1198F .
26935372	0	Crizotinib	20,30	ALK	62,65	Crizotinib	ALK	MESH:C551994	238	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Promising Effect of Crizotinib on Anaplastic_Lymphoma Kinase -LRB- ALK -RRB- - Positive Non-Small_Cell_Lung_Cancer in an Elderly Patient with a Poor Performance Status : A Case Report and Literature Review .
26532540	0	Crizotinib	95,105	Alk	33,36	Crizotinib	Alk	MESH:C551994	238	Chemical	Gene	Burden|nmod|START_ENTITY Burden|nmod|Cancer Cancer|compound|END_ENTITY	Economic Burden of Patients with Alk + Mutation non-Small Cell Lung Cancer After Treatment with Crizotinib : a Canadian Retrospective Observational Study .
26677850	0	Crizotinib	26,36	MTH1	44,48	Crizotinib	MTH1	MESH:C551994	4521	Chemical	Gene	START_ENTITY|nmod|Activity Activity|compound|END_ENTITY	Influence of Chirality of Crizotinib on Its MTH1 Protein Inhibitory Activity : Insight from Molecular Dynamics Simulations and Binding Free Energy Calculations .
25193856	0	Crizotinib	0,10	c-MET	70,75	Crizotinib	c-MET	MESH:C551994	17295(Tax:10090)	Chemical	Gene	exhibits|nsubj|START_ENTITY exhibits|advcl|targeting targeting|advcl|signaling signaling|dobj|END_ENTITY	Crizotinib exhibits antitumor activity by targeting ALK signaling not c-MET in pancreatic_cancer .
21154129	0	Crizotinib	0,10	c-Met	51,56	Crizotinib	c-Met	MESH:C551994	4233	Chemical	Gene	kinases|advmod|START_ENTITY kinases|nsubj|inhibitor inhibitor|nmod|END_ENTITY	Crizotinib , a small-molecule dual inhibitor of the c-Met and ALK receptor tyrosine kinases .
24140933	0	Crizotinib	0,10	c-Met	14,19	Crizotinib	c-Met	MESH:C551994	17295(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Crizotinib , a c-Met inhibitor , prevents metastasis in a metastatic uveal_melanoma model .
24140933	2	Crizotinib	265,275	c-Met	293,298	Crizotinib	c-Met	MESH:C551994	4233	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|kinase kinase|amod|END_ENTITY	Crizotinib , an inhibitor of c-Met , anaplastic_lymphoma kinase -LRB- ALK -RRB- , and ROS1 , inhibited the phosphorylation of the c-Met receptor but not of ALK or ROS1 in uveal_melanoma cells and tumor tissue .
20041429	0	Crocetin	0,8	cyclin_D1	65,74	Crocetin	cyclin D1	MESH:C010561	595	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Crocetin inhibits cell cycle G1/S transition through suppressing cyclin_D1 and elevating p27kip1 in vascular smooth muscle cells .
16804126	0	Crocetin	0,8	tumor_necrosis_factor-alpha	38,65	Crocetin	tumor necrosis factor-alpha	MESH:C010561	24835(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Crocetin inhibits mRNA expression for tumor_necrosis_factor-alpha , interleukin-1beta , and inducible_nitric_oxide_synthase in hemorrhagic_shock .
27084772	0	Crocin	0,6	CX3CR1	19,25	Crocin	CX3CR1	MESH:C029036	1524	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Crocin Upregulates CX3CR1 Expression by Suppressing NF-kB/YY1 Signaling and Inhibiting Lipopolysaccharide-Induced Microglial Activation .
24839356	0	Crocin	0,6	inducible_nitric_oxide_synthase	47,78	Crocin	inducible nitric oxide synthase	MESH:C029036	4843	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|nmod|END_ENTITY	Crocin suppresses LPS-stimulated expression of inducible_nitric_oxide_synthase by upregulation of heme_oxygenase-1 via calcium/calmodulin-dependent protein kinase 4 .
24070736	0	Crotonaldehyde	0,14	heat_shock_protein_72	23,44	Crotonaldehyde	heat shock protein 72	MESH:C012796	3303	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Crotonaldehyde induces heat_shock_protein_72 expression that mediates anti-apoptotic effects in human endothelial cells .
26552209	0	Crypotanshione	1,15	metadherin	42,52	Crypotanshione	metadherin	null	92140	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|nmod|END_ENTITY	-LSB- Crypotanshione reduces the expression of metadherin in DU145_prostate_cancer cells -RSB- .
22490436	0	Cryptotanshinone	0,16	Erk1/2	48,54	Cryptotanshinone	Erk1/2	MESH:C037886	5595;5594	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Cryptotanshinone activates p38/JNK and inhibits Erk1/2 leading to caspase-independent cell death in tumor cells .
23740516	0	Cryptotanshinone	0,16	STAT3	73,78	Cryptotanshinone	STAT3	MESH:C037886	6774	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|suppressing suppressing|dobj|signaling signaling|compound|END_ENTITY	Cryptotanshinone inhibits human glioma cell proliferation by suppressing STAT3 signaling .
26902408	0	Cryptotanshinone	0,16	STAT3	151,156	Cryptotanshinone	STAT3	MESH:C037886	20848(Tax:10090)	Chemical	Gene	inhibits|advmod|START_ENTITY inhibits|nmod|regulation regulation|nmod|expression expression|nmod|signaling signaling|compound|END_ENTITY	Cryptotanshinone , a compound of Salvia miltiorrhiza inhibits pre-adipocytes differentiation by regulation of adipogenesis-related genes expression via STAT3 signaling .
25912550	0	Cryptotanshinone	0,16	Stat3	20,25	Cryptotanshinone	Stat3	MESH:C037886	6774	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Cryptotanshinone , a Stat3 inhibitor , suppresses colorectal_cancer proliferation and growth in vitro .
26728374	0	Cryptotanshinone	1,17	VEGF	51,55	Cryptotanshinone	VEGF	MESH:C037886	7422	Chemical	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|nmod|END_ENTITY	-LSB- Cryptotanshinone down-regulates the expression of VEGF and inhibits angiogenesis in U2OS_osteosarcoma cells -RSB- .
19774505	0	Cryptotanshinone	0,16	acetylcholinesterase	21,41	Cryptotanshinone	acetylcholinesterase	MESH:C037886	83817(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Cryptotanshinone , an acetylcholinesterase inhibitor from Salvia miltiorrhiza , ameliorates scopolamine-induced amnesia in Morris water maze task .
22052438	0	Cryptotanshinone	0,16	androgen_receptor	32,49	Cryptotanshinone	androgen receptor	MESH:C037886	367	Chemical	Gene	down-regulates|amod|START_ENTITY END_ENTITY|nsubj|down-regulates	Cryptotanshinone down-regulates androgen_receptor signaling by modulating lysine-specific_demethylase_1 function .
16989810	0	Cryptotanshinone	0,16	cyclooxygenase-2	26,42	Cryptotanshinone	cyclooxygenase-2	MESH:C037886	5743	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Cryptotanshinone inhibits cyclooxygenase-2 enzyme activity but not its expression .
16289876	0	Cryptotanshinone	0,16	endothelin-1	26,38	Cryptotanshinone	endothelin-1	MESH:C037886	1906	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Cryptotanshinone inhibits endothelin-1 expression and stimulates nitric_oxide production in human vascular endothelial cells .
25605261	0	Cryptotanshinone	22,38	nuclear_factor_kappa_B	92,114	Cryptotanshinone	nuclear factor kappa B	MESH:C037886	309165(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Therapeutic effect of Cryptotanshinone on collagen-induced_arthritis in rats via inhibiting nuclear_factor_kappa_B signaling pathway .
10693638	0	CsA	94,97	TGF-beta1	24,33	CsA	TGF-beta1	CHEBI:55379	7040	Chemical	Gene	converted|nmod|START_ENTITY converted|nsubj|study study|nmod|levels levels|compound|END_ENTITY	A longitudinal study of TGF-beta1 protein levels in renal allograft recipients converted from CsA to MMF or AZA .
12198207	12	CsA	2321,2324	TGF-beta1	2243,2252	CsA	TGF-beta1	CHEBI:55379	59086(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|advcl|mediated mediated|nmod|END_ENTITY	Whereas up-regulation of PAI-1 is mediated by TGF-beta1 , up-regulation of FN is-at least in part-either directly induced by CsA or mediated by factors other than TGF-beta1 .
9112364	4	CsA	603,606	TGF-beta1	630,639	CsA	TGF-beta1	CHEBI:55379	21803(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	RESULTS : CsA pretreatment augmented TGF-beta1 protein expression and increased intrarenal display of TGF-beta1 mRNA .
10766745	0	CtBP	25,29	Ikaros	0,6	CtBP	Ikaros	null	10320	Chemical	Gene	interactions|nmod|START_ENTITY interactions|amod|END_ENTITY	Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity .
16547505	0	CtBP	93,97	TCF-4	0,5	CtBP	TCF-4	null	6925	Chemical	Gene	isoforms|nmod|START_ENTITY isoforms|nsubj|END_ENTITY	TCF-4 isoforms absent in TCF-4 mutated MSI-H_colorectal_cancer cells colocalize with nuclear CtBP and repress TCF-4-mediated transcription .
11313276	0	CtBP	16,20	transforming_growth_factor_beta	53,84	CtBP	transforming growth factor beta	null	7040	Chemical	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The corepressor CtBP interacts with Evi-1 to repress transforming_growth_factor_beta signaling .
20595380	0	Cu	0,2	COMMD1	68,74	Cu	COMMD1	null	150684	Chemical	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Cu , Zn_superoxide dismutase maturation and activity are regulated by COMMD1 .
23126503	0	Cu	61,63	LOX-1	94,99	Cu	LOX-1	null	4973	Chemical	Gene	complex|compound|START_ENTITY complex|nmod|site site|nmod|END_ENTITY	Comparative binding effects of aspirin and anti-inflammatory Cu complex in the active site of LOX-1 .
15296261	0	Cu	87,89	LiF	80,83	Cu	LiF	null	3976	Chemical	Gene	Effect|dep|START_ENTITY Effect|nmod|END_ENTITY	Effect of reader and oven annealing on the glow curve structure and fading of a LiF : Mg , Cu , P_TL dosimeter .
21683603	0	Cu	64,66	LiF	57,60	Cu	LiF	null	3976	Chemical	Gene	effect|dep|START_ENTITY effect|nmod|END_ENTITY	Heating rate effect on thermoluminescence glow curves of LiF : Mg , Cu , P+PTFE phosphor .
11561030	3	Cu	715,717	SOD1	745,749	Cu	SOD1	null	6647	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	METHOD : Using the statistical technique of motor unit number estimation , a cross sectional study was performed on a group of asymptomatic carriers of the Cu , Zn_superoxide dimutase 1 -LRB- SOD1 -RRB- gene .
21548977	0	Cu	0,2	SOD1	31,35	Cu	SOD1	null	6647	Chemical	Gene	dismutase|compound|START_ENTITY dismutase|appos|END_ENTITY	Cu , Zn-superoxide dismutase 1 -LRB- SOD1 -RRB- is a novel target of Puromycin-sensitive aminopeptidase -LRB- PSA/NPEPPS -RRB- : PSA/NPEPPS is a possible modifier of amyotrophic_lateral_sclerosis .
1342926	0	Cu	30,32	Sod	36,39	Cu	Sod	null	101451855	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Structure and sequence of the Cu , Zn Sod gene in the Mediterranean_fruit_fly , Ceratitis_capitata : intron insertion/deletion and evolution of the gene .
14637279	0	Cu-Zn_superoxide	47,63	glutathione_reductase	24,45	Cu-Zn superoxide	glutathione reductase	null	2936	Chemical	Gene	activities|amod|START_ENTITY activities|amod|END_ENTITY	Glutathione peroxidase , glutathione_reductase , Cu-Zn_superoxide dismutase activities , glutathione , nitric_oxide , and malondialdehyde concentrations in serum of patients with chronic_lymphocytic_leukemia .
8385487	0	CuA	31,34	cytochrome_c_oxidase	43,63	CuA	cytochrome c oxidase	null	282199(Tax:9913)	Chemical	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Resonance Raman studies on the CuA site of cytochrome_c_oxidase using a multichannel scanning Raman spectrometer with a CCD detector .
14564556	0	CuB	39,42	cytochrome_c	46,58	CuB	cytochrome c	null	54205	Chemical	Gene	START_ENTITY|nmod|oxidase oxidase|amod|END_ENTITY	Could the tyrosine-histidine ligand to CuB in cytochrome_c oxidase be coordinatively labile ?
11880116	0	CuCl2	10,15	alpha-L-iduronidase	45,64	CuCl2	alpha-L-iduronidase	MESH:C029892	3425	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of CuCl2 , NaCl and EDTA on the enzyme alpha-L-iduronidase in the plasma of normal individuals and heterozygotes for MPS_I .
19700240	0	Cucurbitacin_B	0,14	STAT3	24,29	Cucurbitacin B	STAT3	MESH:C041246	6774	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Cucurbitacin_B inhibits STAT3 and the Raf/MEK/ERK pathway in leukemia cell line K562 .
24316209	0	Cucurbitacin_B	0,14	STAT3	91,96	Cucurbitacin B	STAT3	MESH:C041246	20848(Tax:10090)	Chemical	Gene	suppress|nsubj|START_ENTITY suppress|nmod|inhibition inhibition|nmod|signaling signaling|compound|END_ENTITY	Cucurbitacin_B and cucurbitacin_I suppress adipocyte differentiation through inhibition of STAT3 signaling .
20483353	0	Cucurbitacin_B	0,14	Stat3	50,55	Cucurbitacin B	Stat3	MESH:C041246	6774	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Cucurbitacin_B , a small molecule inhibitor of the Stat3 signaling pathway , enhances the chemosensitivity of laryngeal_squamous_cell_carcinoma cells to cisplatin .
24333213	0	Cucurbitacin_B	0,14	hypoxia-inducible_factor-1a	56,83	Cucurbitacin B	hypoxia-inducible factor-1a	MESH:C041246	3091	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Cucurbitacin_B inhibits the translational expression of hypoxia-inducible_factor-1a .
23478800	0	Cucurbitacin_I	0,14	Janus_tyrosine_kinase_2	132,155	Cucurbitacin I	Janus tyrosine kinase 2	MESH:C038106	3717	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	Cucurbitacin_I inhibits Rac1 activation in breast_cancer cells by a reactive oxygen species-mediated mechanism and independently of Janus_tyrosine_kinase_2 and P-Rex1 .
23478800	0	Cucurbitacin_I	0,14	Rac1	24,28	Cucurbitacin I	Rac1	MESH:C038106	5879	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	Cucurbitacin_I inhibits Rac1 activation in breast_cancer cells by a reactive oxygen species-mediated mechanism and independently of Janus_tyrosine_kinase_2 and P-Rex1 .
18200050	0	Cucurbitacin_I	0,14	Stat3	24,29	Cucurbitacin I	Stat3	MESH:C038106	6774	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Cucurbitacin_I inhibits Stat3 and induces apoptosis in S zary cells .
15735720	0	Cucurbitacin_Q	0,14	STAT3	28,33	Cucurbitacin Q	STAT3	MESH:C500746	20848(Tax:10090)	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Cucurbitacin_Q : a selective STAT3 activation inhibitor with potent antitumor activity .
23843889	0	Cucurbitane_Triterpenoid	0,24	Peroxisome_Proliferator-Activated_Receptor	123,165	Cucurbitane Triterpenoid	Peroxisome Proliferator-Activated Receptor	null	5465	Chemical	Gene	START_ENTITY|nmod|Activation Activation|compound|END_ENTITY	Cucurbitane_Triterpenoid from Momordica charantia Induces Apoptosis and Autophagy in Breast_Cancer Cells , in Part , through Peroxisome_Proliferator-Activated_Receptor y Activation .
24117066	0	Curcumin	0,8	ABCA1	17,22	Curcumin	ABCA1	MESH:D003474	313210(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Curcumin induces ABCA1 expression and apolipoprotein_A-I-mediated cholesterol transmembrane in the chronic cerebral_hypoperfusion aging rats .
25445048	0	Curcumin	0,8	AMPK	93,97	Curcumin	AMPK	MESH:D003474	5563	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|pathway pathway|compound|END_ENTITY	Curcumin regulates peroxisome_proliferator-activated_receptor-y coactivator-1a expression by AMPK pathway in hepatic stellate cells in vitro .
19018768	0	Curcumin	0,8	AhR	126,129	Curcumin	AhR	MESH:D003474	196	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|nmod|END_ENTITY	Curcumin attenuates cytochrome P450 induction in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin by ROS-dependently degrading AhR and ARNT .
17218783	0	Curcumin	0,8	Akt	107,110	Curcumin	Akt	MESH:D003474	207	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|modulating modulating|dobj|END_ENTITY	Curcumin induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian_cancer cells by modulating Akt and p38 MAPK .
25875220	0	Curcumin	0,8	Albumin	41,48	Curcumin	Albumin	MESH:D003474	213	Chemical	Gene	Excretion|compound|START_ENTITY Excretion|nmod|END_ENTITY	Curcumin Attenuates Urinary Excretion of Albumin in Type II Diabetic Patients with Enhancing Nuclear_Factor_Erythroid-Derived_2-Like_2 -LRB- Nrf2 -RRB- System and Repressing Inflammatory Signaling Efficacies .
25875220	0	Curcumin	0,8	Albumin	41,48	Curcumin	Albumin	MESH:D003474	213	Chemical	Gene	Excretion|compound|START_ENTITY Excretion|nmod|END_ENTITY	Curcumin Attenuates Urinary Excretion of Albumin in Type II Diabetic Patients with Enhancing Nuclear_Factor_Erythroid-Derived_2-Like_2 -LRB- Nrf2 -RRB- System and Repressing Inflammatory Signaling Efficacies .
24083709	0	Curcumin	0,8	Bax	103,106	Curcumin	Bax	MESH:D003474	581	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|regulation regulation|nmod|END_ENTITY	Curcumin inhibits human non-small_cell_lung_cancer A549 cell proliferation through regulation of Bcl-2 / Bax and cytochrome_C .
11756235	0	Curcumin	0,8	Bcl-2	160,165	Curcumin	Bcl-2	MESH:D003474	596	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|release release|dep|suppression suppression|nmod|expression expression|nmod|END_ENTITY	Curcumin -LRB- diferuloylmethane -RRB- induces apoptosis through activation of caspase-8 , BID cleavage and cytochrome_c release : its suppression by ectopic expression of Bcl-2 and Bcl-xl .
17392282	0	Curcumin	0,8	Bcl-2	74,79	Curcumin	Bcl-2	MESH:D003474	596	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|dobj|apoptosis apoptosis|nmod|induction induction|compound|END_ENTITY	Curcumin prevents tumor-induced T cell apoptosis through Stat-5a-mediated Bcl-2 induction .
19086645	0	Curcumin	1,9	Bcl-2	106,111	Curcumin	Bcl-2	MESH:D003474	596	Chemical	Gene	inhibits|nsubj|START_ENTITY induces|ccomp|inhibits induces|advcl|regulating regulating|dobj|/ /|compound|END_ENTITY	-LSB- Curcumin inhibits growth , induces G1_arrest and apoptosis on human prostatic stromal cells by regulating Bcl-2 / Bax -RSB- .
19283527	0	Curcumin	0,8	Bcl-2	103,108	Curcumin	Bcl-2	MESH:D003474	596	Chemical	Gene	sensitizes|nsubj|START_ENTITY sensitizes|nmod|degradation degradation|compound|END_ENTITY	Curcumin sensitizes lung_cancer cells to cisplatin-induced apoptosis through superoxide anion-mediated Bcl-2 degradation .
19288022	0	Curcumin	0,8	Bcl-2	71,76	Curcumin	Bcl-2	MESH:D003474	596	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|increasing increasing|dobj|ratio ratio|amod|END_ENTITY	Curcumin inhibits proliferation and migration by increasing the Bax to Bcl-2 ratio and decreasing NF-kappaBp65 expression in breast_cancer MDA-MB-231 cells .
19908170	0	Curcumin	0,8	Bcl-2	35,40	Curcumin	Bcl-2	MESH:D003474	596	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|nmod|END_ENTITY	Curcumin reduces the expression of Bcl-2 by upregulating miR-15a and miR-16 in MCF-7 cells .
20127174	0	Curcumin	0,8	Bcl-2	101,106	Curcumin	Bcl-2	MESH:D003474	596	Chemical	Gene	sensitizes|nsubj|START_ENTITY sensitizes|nmod|downregulation downregulation|compound|END_ENTITY	Curcumin sensitizes non-small_cell_lung_cancer cell anoikis through reactive oxygen species-mediated Bcl-2 downregulation .
21595920	0	Curcumin	0,8	Bcl-2	31,36	Curcumin	Bcl-2	MESH:D003474	596	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|nmod|END_ENTITY	Curcumin reduces expression of Bcl-2 , leading to apoptosis in daunorubicin-insensitive CD34 + acute_myeloid_leukemia cell lines and primary sorted CD34 + acute_myeloid_leukemia cells .
24083709	0	Curcumin	0,8	Bcl-2	97,102	Curcumin	Bcl-2	MESH:D003474	596	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|regulation regulation|nmod|Bax Bax|compound|END_ENTITY	Curcumin inhibits human non-small_cell_lung_cancer A549 cell proliferation through regulation of Bcl-2 / Bax and cytochrome_C .
24743574	0	Curcumin	0,8	Bcl-2	171,176	Curcumin	Bcl-2	MESH:D003474	596	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|ccomp|apoptosis apoptosis|nmod|down-regulation down-regulation|nmod|expression expression|compound|END_ENTITY	Curcumin significantly enhances dual PI3K/Akt and mTOR inhibitor NVP-BEZ235-induced apoptosis in human renal_carcinoma Caki cells through down-regulation of p53-dependent Bcl-2 expression and inhibition of Mcl-1 protein stability .
19360344	0	Curcumin	0,8	CCL2	98,102	Curcumin	CCL2	MESH:D003474	6347	Chemical	Gene	blocks|compound|START_ENTITY CCL2-induced|nsubj|blocks CCL2-induced|nmod|down-regulation down-regulation|nmod|expression expression|nummod|END_ENTITY	Curcumin blocks CCL2-induced adhesion , motility and invasion , in part , through down-regulation of CCL2 expression and proteolytic activity .
22410671	0	Curcumin	0,8	CCL2	30,34	Curcumin	CCL2	MESH:D003474	24770(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Curcumin inhibits LPS-induced CCL2 expression via JNK pathway in C6 rat astrocytoma cells .
23609161	0	Curcumin	0,8	CCN2	32,36	Curcumin	CCN2	MESH:D003474	1490	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Curcumin inhibits TGFb1-induced CCN2 via Src , JNK , and Smad3 in gingiva .
24223665	0	Curcumin	0,8	CD133	64,69	Curcumin	CD133	MESH:D003474	8842	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|cells cells|amod|END_ENTITY	Curcumin enhances the effectiveness of cisplatin by suppressing CD133 -LRB- + -RRB- cancer stem cells in laryngeal_carcinoma treatment .
22511637	0	Curcumin	0,8	CD36	93,97	Curcumin	CD36	MESH:D003474	948	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|up-regulation up-regulation|nmod|expression expression|compound|END_ENTITY	Curcumin enhances non-opsonic phagocytosis of Plasmodium_falciparum through up-regulation of CD36 surface expression on monocytes/macrophages .
23603106	0	Curcumin	0,8	CD36	32,36	Curcumin	CD36	MESH:D003474	12491(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Curcumin inhibits oxLDL-induced CD36 expression and foam cell formation through the inhibition of p38_MAPK phosphorylation .
12807725	0	Curcumin	0,8	COX-2	195,200	Curcumin	COX-2	MESH:D003474	4513	Chemical	Gene	cigarette|compound|START_ENTITY cigarette|dep|correlation correlation|nmod|suppression suppression|nmod|END_ENTITY	Curcumin -LRB- diferuloylmethane -RRB- down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells : correlation with suppression of COX-2 , MMP-9 and cyclin_D1 .
16000872	0	Curcumin	0,8	COX-2	36,41	Curcumin	COX-2	MESH:D003474	5743	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Curcumin inhibits the expression of COX-2 in UVB-irradiated human keratinocytes -LRB- HaCaT -RRB- by inhibiting activation of AP-1 : p38 MAP kinase and JNK as potential upstream targets .
17276891	0	Curcumin	0,8	COX-2	75,80	Curcumin	COX-2	MESH:D003474	26198(Tax:10116)	Chemical	Gene	acts|nsubj|START_ENTITY acts|advcl|modulating modulating|dobj|expression expression|amod|END_ENTITY	Curcumin , a Curcuma longa constituent , acts on MAPK p38 pathway modulating COX-2 and iNOS expression in chronic experimental colitis .
22256765	0	Curcumin	1,9	CX3CR1	25,31	Curcumin	CX3CR1	MESH:D003474	171056(Tax:10116)	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	-LSB- Curcumin down-regulates CX3CR1 expression in spinal cord dorsal horn and DRG in neuropathic_pain rats -RSB- .
17918158	0	Curcumin	0,8	EGFR	131,135	Curcumin	EGFR	MESH:D003474	1956	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|advcl|mediating mediating|advcl|modulating modulating|dobj|END_ENTITY	Curcumin enhances the effects of 5-fluorouracil and oxaliplatin in mediating growth inhibition of colon_cancer cells by modulating EGFR and IGF-1R .
21858220	0	Curcumin	0,8	EGFR	17,21	Curcumin	EGFR	MESH:D003474	1956	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|degradation degradation|amod|END_ENTITY	Curcumin induces EGFR degradation in lung_adenocarcinoma and modulates p38 activation in intestine : the versatile adjuvant for gefitinib therapy .
23023821	0	Curcumin	0,8	EGFR	83,87	Curcumin	EGFR	MESH:D003474	1956	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|inhibition inhibition|nmod|expression expression|amod|END_ENTITY	Curcumin induces apoptosis of triple-negative breast_cancer cells by inhibition of EGFR expression .
25400722	0	Curcumin	0,8	EGFR	78,82	Curcumin	EGFR	MESH:D003474	1956	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|proliferation proliferation|nmod|END_ENTITY	Curcumin inhibits oral_squamous_cell_carcinoma proliferation and invasion via EGFR signaling pathways .
25893361	0	Curcumin	19,27	EGFR	0,4	Curcumin	EGFR	MESH:D003474	1956	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|compound|END_ENTITY	EGFR Inhibition by Curcumin in Cancer Cells : A Dual Mode of Action .
26505786	0	Curcumin	25,33	EGFR	139,143	Curcumin	EGFR	MESH:D003474	1956	Chemical	Gene	Effects|nmod|START_ENTITY Effects|dep|Regulation Regulation|nmod|END_ENTITY	Combinatorial Effects of Curcumin with an Anti-Neoplastic Agent on Head_and_Neck_Squamous_Cell_Carcinoma -LRB- HNSCC -RRB- Through the Regulation of EGFR - ERK1/2 and Apoptotic Signaling Pathways .
25241044	0	Curcumin	0,8	EMMPRIN	18,25	Curcumin	EMMPRIN	MESH:D003474	682	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Curcumin inhibits EMMPRIN and MMP-9 expression through AMPK-MAPK and PKC signaling in PMA induced macrophages .
19766691	0	Curcumin	0,8	ERK	89,92	Curcumin	ERK	MESH:D003474	5594	Chemical	Gene	phorbol_myristate_acetate|compound|START_ENTITY phorbol_myristate_acetate|dep|expression expression|acl|inhibiting inhibiting|dobj|END_ENTITY	Curcumin inhibits phorbol_myristate_acetate -LRB- PMA -RRB- - induced MCP-1 expression by inhibiting ERK and NF-kappaB transcriptional activity .
23317243	0	Curcumin	0,8	ERK	60,63	Curcumin	ERK	MESH:D003474	5594	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Curcumin inhibits TGF-b1-induced MMP-9 and invasion through ERK and Smad signaling in breast_cancer MDA - MB-231 cells .
20385124	0	Curcumin	0,8	EZH2	36,40	Curcumin	EZH2	MESH:D003474	2146	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|down-regulation down-regulation|nmod|expression expression|compound|END_ENTITY	Curcumin induces down-regulation of EZH2 expression through the MAPK pathway in MDA-MB-435 human breast_cancer cells .
23888319	0	Curcumin	0,8	FOXO1	78,83	Curcumin	FOXO1	MESH:D003474	2308	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|induction induction|nmod|END_ENTITY	Curcumin inhibits lung_cancer progression and metastasis through induction of FOXO1 .
27039889	0	Curcumin	0,8	GLUT1	53,58	Curcumin	GLUT1	MESH:D003474	20525(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	Curcumin directly inhibits the transport activity of GLUT1 .
17143561	1	Curcumin	124,132	HO-1	210,214	Curcumin	HO-1	MESH:D003474	3162	Chemical	Gene	compound|nsubj|START_ENTITY compound|ccomp|known known|xcomp|induce induce|dobj|heme_oxygenase_1 heme_oxygenase_1|appos|END_ENTITY	Curcumin is a naturally occurring compound which is known to induce heme_oxygenase_1 -LRB- HO-1 -RRB- , although the underlying mechanism has not been fully elucidated .
19445907	0	Curcumin	0,8	HO-1	48,52	Curcumin	HO-1	MESH:D003474	24451(Tax:10116)	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|Nrf2 Nrf2|appos|expression expression|compound|END_ENTITY	Curcumin upregulates transcription factor Nrf2 , HO-1 expression and protects rat brains against focal ischemia .
26294283	0	Curcumin	0,8	HSP70	19,24	Curcumin	HSP70	MESH:D003474	266759(Tax:10116)	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Curcumin Increases HSP70 Expression in Primary Rat Cortical Neuronal Apoptosis Induced by gp120 V3 Loop Peptide .
19177192	0	Curcumin	31,39	Heme_Oxygenase-1	58,74	Curcumin	Heme Oxygenase-1	MESH:D003474	3162	Chemical	Gene	Analogue|compound|START_ENTITY Dimethoxycurcumin|appos|Analogue Induces|nsubj|Dimethoxycurcumin Induces|dobj|Expression Expression|compound|END_ENTITY	Dimethoxycurcumin , a Synthetic Curcumin Analogue , Induces Heme_Oxygenase-1 Expression through Nrf2 Activation in RAW264 .7 Macrophages .
18357586	0	Curcumin	58,66	Heme_oxygenase-1	0,16	Curcumin	Heme oxygenase-1	MESH:D003474	3162	Chemical	Gene	effect|nmod|START_ENTITY mediates|dobj|effect mediates|nsubj|END_ENTITY	Heme_oxygenase-1 mediates the anti-inflammatory effect of Curcumin within LPS-stimulated human monocytes .
20125031	0	Curcumin	0,8	Hsp27	151,156	Curcumin	Hsp27	MESH:D003474	24471(Tax:10116)	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|expression expression|nmod|END_ENTITY	Curcumin protects rat myocardium against isoproterenol-induced ischemic_injury : attenuation of ventricular_dysfunction through increased expression of Hsp27 along with strengthening antioxidant defense system .
18093618	0	Curcumin	0,8	Hsp70	89,94	Curcumin	Hsp70	MESH:D003474	15511(Tax:10090)	Chemical	Gene	treatment|compound|START_ENTITY enhances|nsubj|treatment enhances|nmod|induction induction|amod|END_ENTITY	Curcumin treatment enhances islet recovery by induction of heat_shock response proteins , Hsp70 and heme_oxygenase-1 , during cryopreservation .
23977989	0	Curcumin	0,8	ICAM-1	35,41	Curcumin	ICAM-1	MESH:D003474	3383	Chemical	Gene	ameliorates|nsubj|START_ENTITY ameliorates|dobj|expression expression|compound|END_ENTITY	Curcumin ameliorates TNF-a-induced ICAM-1 expression and subsequent THP-1 adhesiveness via the induction of heme_oxygenase-1 in the HaCaT cells .
20127863	0	Curcumin	0,8	IGFBP-5	67,74	Curcumin	IGFBP-5	MESH:D003474	16011(Tax:10090)	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	Curcumin upregulates insulin-like_growth_factor_binding_protein-5 -LRB- IGFBP-5 -RRB- and C/EBPalpha during oral_cancer suppression .
17273796	0	Curcumin	0,8	IL-1beta	38,46	Curcumin	IL-1beta	MESH:D003474	3553	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|nmod|END_ENTITY	Curcumin attenuates the expression of IL-1beta , IL-6 , and TNF-alpha as well as cyclin E in TNF-alpha-treated HaCaT cells ; NF-kappaB and MAPKs as potential upstream targets .
25944087	0	Curcumin	0,8	IL-4	57,61	Curcumin	IL-4	MESH:D003474	287287(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Curcumin induces M2 macrophage polarization by secretion IL-4 and/or IL-13 .
9439980	0	Curcumin	0,8	IL1_alpha	18,27	Curcumin	IL1 alpha	MESH:D003474	3552	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|induction induction|amod|END_ENTITY	Curcumin inhibits IL1_alpha and TNF-alpha induction of AP-1 and NF-kB DNA-binding activity in bone marrow stromal cells .
18704882	0	Curcumin	0,8	LDL_receptor	22,34	Curcumin	LDL receptor	MESH:D003474	3949	Chemical	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|compound|END_ENTITY	Curcumin up-regulates LDL_receptor expression via the sterol regulatory element pathway in HepG2 cells .
17112893	0	Curcumin	0,8	MCP-1	27,32	Curcumin	MCP-1	MESH:D003474	20296(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|release release|amod|END_ENTITY	Curcumin inhibits in vitro MCP-1 release from mouse pancreatic islets .
19766691	0	Curcumin	0,8	MCP-1	58,63	Curcumin	MCP-1	MESH:D003474	6347	Chemical	Gene	phorbol_myristate_acetate|compound|START_ENTITY phorbol_myristate_acetate|dep|expression expression|compound|END_ENTITY	Curcumin inhibits phorbol_myristate_acetate -LRB- PMA -RRB- - induced MCP-1 expression by inhibiting ERK and NF-kappaB transcriptional activity .
22005927	0	Curcumin	0,8	MCP-1	33,38	Curcumin	MCP-1	MESH:D003474	24770(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Curcumin inhibits ox-LDL-induced MCP-1 expression by suppressing the p38MAPK and NF-kB pathways in rat vascular smooth muscle cells .
17341208	0	Curcumin	0,8	MMP-2	35,40	Curcumin	MMP-2	MESH:D003474	4313	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|HEp2 HEp2|amod|END_ENTITY	Curcumin , a potential inhibitor of MMP-2 in human laryngeal_squamous_carcinoma cells HEp2 .
23259320	0	Curcumin	0,8	MMP-2	56,61	Curcumin	MMP-2	MESH:D003474	17390(Tax:10090)	Chemical	Gene	delays|compound|START_ENTITY endometriosis|nsubj|delays endometriosis|advcl|inhibiting inhibiting|dobj|activity activity|compound|END_ENTITY	Curcumin delays endometriosis development by inhibiting MMP-2 activity .
26036622	0	Curcumin	0,8	Matrix_Metalloproteinase_2	118,144	Curcumin	Matrix Metalloproteinase 2	MESH:D003474	4313	Chemical	Gene	Invasiveness|compound|START_ENTITY Through|nsubj|Invasiveness Through|xcomp|Reducing Reducing|dobj|END_ENTITY	Curcumin Inhibits Invasiveness and Epithelial-Mesenchymal Transition in Oral_Squamous_Cell_Carcinoma Through Reducing Matrix_Metalloproteinase_2 , 9 and Modulating p53-E-Cadherin Pathway .
21663638	0	Curcumin	0,8	NF-kB	59,64	Curcumin	NF-kB	MESH:D003474	81736(Tax:10116)	Chemical	Gene	ameliorates|nsubj|START_ENTITY ameliorates|advcl|inhibiting inhibiting|dobj|activation activation|amod|END_ENTITY	Curcumin ameliorates macrophage infiltration by inhibiting NF-kB activation and proinflammatory cytokines in streptozotocin induced-diabetic_nephropathy .
25912594	0	Curcumin	14,22	NF-kB	26,31	Curcumin	NF-kB	MESH:D003474	309165(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|amod|END_ENTITY	The effect of Curcumin on NF-kB expression in rat with lumbar intervertebral_disc_degeneration .
25912594	0	Curcumin	14,22	NF-kB	26,31	Curcumin	NF-kB	MESH:D003474	309165(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|amod|END_ENTITY	The effect of Curcumin on NF-kB expression in rat with lumbar intervertebral_disc_degeneration .
26111829	0	Curcumin	0,8	NF-kB	63,68	Curcumin	NF-kB	MESH:D003474	81736(Tax:10116)	Chemical	Gene	alleviates|nsubj|START_ENTITY alleviates|advcl|inhibiting inhibiting|dobj|pathway pathway|amod|END_ENTITY	Curcumin alleviates lung_injury in diabetic rats by inhibiting NF-kB pathway .
26686249	0	Curcumin	0,8	NF-kB	28,33	Curcumin	NF-kB	MESH:D003474	81736(Tax:10116)	Chemical	Gene	START_ENTITY|acl|regulating regulating|dobj|END_ENTITY	Curcumin by down regulating NF-kB and elevating Nrf2 , reduces brain_edema and neurological_dysfunction after cerebral I/R .
12297018	0	Curcumin	0,8	NF-kappaB	34,43	Curcumin	NF-kappaB	MESH:D003474	4790	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|activation activation|nmod|END_ENTITY	Curcumin suppresses activation of NF-kappaB and AP-1 induced by phorbol_ester in cultured human promyelocytic_leukemia cells .
12807725	0	Curcumin	0,8	NF-kappaB	68,77	Curcumin	NF-kappaB	MESH:D003474	4790	Chemical	Gene	cigarette|compound|START_ENTITY cigarette|acl|smoke-induced smoke-induced|dobj|activation activation|amod|END_ENTITY	Curcumin -LRB- diferuloylmethane -RRB- down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells : correlation with suppression of COX-2 , MMP-9 and cyclin_D1 .
15582125	0	Curcumin	0,8	NF-kappaB	18,27	Curcumin	NF-kappaB	MESH:D003474	18033(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	Curcumin inhibits NF-kappaB activation and reduces the severity of experimental steatohepatitis in mice .
17885582	0	Curcumin	0,8	NF-kappaB	52,61	Curcumin	NF-kappaB	MESH:D003474	18033(Tax:10090)	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|activity activity|nmod|END_ENTITY	Curcumin downregulates the constitutive activity of NF-kappaB and induces apoptosis in novel mouse melanoma cells .
18638545	0	Curcumin	0,8	NF-kappaB	98,107	Curcumin	NF-kappaB	MESH:D003474	4790	Chemical	Gene	protects|nsubj|START_ENTITY protects|parataxis|effects effects|nmod|END_ENTITY	Curcumin protects cardiac cells against ischemia-reperfusion injury : effects on oxidative stress , NF-kappaB , and JNK pathways .
19735878	0	Curcumin	0,8	NF-kappaB	109,118	Curcumin	NF-kappaB	MESH:D003474	4790	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|advcl|suppressing suppressing|dobj|activity activity|amod|END_ENTITY	Curcumin modulates the radiosensitivity of colorectal_cancer cells by suppressing constitutive and inducible NF-kappaB activity .
19445907	0	Curcumin	0,8	Nrf2	42,46	Curcumin	Nrf2	MESH:D003474	83619(Tax:10116)	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	Curcumin upregulates transcription factor Nrf2 , HO-1 expression and protects rat brains against focal ischemia .
22645638	0	Curcumin	0,8	Nrf2	20,24	Curcumin	Nrf2	MESH:D003474	18024(Tax:10090)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|END_ENTITY	Curcumin attenuates Nrf2 signaling defect , oxidative stress in muscle and glucose_intolerance in high fat diet-fed mice .
25444713	0	Curcumin	0,8	Nrf2	63,67	Curcumin	Nrf2	MESH:D003474	18024(Tax:10090)	Chemical	Gene	protects|nsubj|START_ENTITY protects|advcl|activating activating|dobj|END_ENTITY	Curcumin protects hearts from FFA-induced injury by activating Nrf2 and inactivating NF-kB both in vitro and in vivo .
24511364	0	Curcumin	0,8	P-Glycoprotein	46,60	Curcumin	P-Glycoprotein	MESH:D003474	287115(Tax:10116)	Chemical	Gene	Colon_Cancer|compound|START_ENTITY Colon_Cancer|nmod|END_ENTITY	Curcumin Regulates Colon_Cancer by Inhibiting P-Glycoprotein in In-situ Cancerous Colon Perfusion Rat Model .
19294764	0	Curcumin	0,8	PPARdelta	20,29	Curcumin	PPARdelta	MESH:D003474	5467	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Curcumin suppresses PPARdelta expression and related genes in HT-29 cells .
19444642	0	Curcumin	0,8	Pokemon	37,44	Curcumin	Pokemon	MESH:D003474	51341	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|nmod|END_ENTITY	Curcumin decreases the expression of Pokemon by suppressing the binding activity of the Sp1 protein in human lung_cancer cells .
26983836	0	Curcumin	71,79	Protein_Kinase_C	24,40	Curcumin	Protein Kinase C	MESH:D003474	112476	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|END_ENTITY	Selective Modulation of Protein_Kinase_C a over Protein_Kinase_C by Curcumin and Its Derivatives in CHO-K1 Cells .
26983836	0	Curcumin	71,79	Protein_Kinase_C	48,64	Curcumin	Protein Kinase C	MESH:D003474	112476	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|Protein_Kinase_C Protein_Kinase_C|nmod|END_ENTITY	Selective Modulation of Protein_Kinase_C a over Protein_Kinase_C by Curcumin and Its Derivatives in CHO-K1 Cells .
21529317	0	Curcumin	0,8	RANTES	52,58	Curcumin	RANTES	MESH:D003474	81780(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|nmod|END_ENTITY	Curcumin attenuates the expression and secretion of RANTES after spinal_cord_injury in vivo and lipopolysaccharide-induced astrocyte reactivation in vitro .
21994947	0	Curcumin	0,8	SMILE	99,104	Curcumin	SMILE	MESH:D003474	58487	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Curcumin differentially regulates endoplasmic reticulum stress through transcriptional corepressor SMILE -LRB- small_heterodimer_partner-interacting_leucine_zipper_protein -RRB- - mediated inhibition of CREBH -LRB- cAMP_responsive_element-binding_protein_H -RRB- .
20235152	0	Curcumin	0,8	STAT-3	47,53	Curcumin	STAT-3	MESH:D003474	6774	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|activation activation|nmod|END_ENTITY	Curcumin suppresses constitutive activation of STAT-3 by up-regulating protein inhibitor of activated STAT-3 -LRB- PIAS-3 -RRB- in ovarian and endometrial_cancer cells .
14500688	0	Curcumin	0,8	STAT3	70,75	Curcumin	STAT3	MESH:D003474	6774	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Curcumin -LRB- diferuloylmethane -RRB- inhibits constitutive and IL-6-inducible STAT3 phosphorylation in human multiple_myeloma cells .
19724924	0	Curcumin	0,8	STAT3	35,40	Curcumin	STAT3	MESH:D003474	6774	Chemical	Gene	GO-Y030|compound|START_ENTITY inhibits|nsubj|GO-Y030 inhibits|dobj|activity activity|compound|END_ENTITY	Curcumin analogue GO-Y030 inhibits STAT3 activity and cell growth in breast_and_pancreatic_carcinomas .
20121547	0	Curcumin	0,8	STAT3	31,36	Curcumin	STAT3	MESH:D003474	6774	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Curcumin inhibits constitutive STAT3 phosphorylation in human pancreatic_cancer cell lines and downregulation of survivin/BIRC5 gene expression .
23856612	0	Curcumin	0,8	STAT3	85,90	Curcumin	STAT3	MESH:D003474	20848(Tax:10090)	Chemical	Gene	ameliorates|nsubj|START_ENTITY ameliorates|advcl|blocking blocking|dobj|END_ENTITY	Curcumin ameliorates dextran sulfate sodium-induced experimental colitis by blocking STAT3 signaling pathway .
24692720	0	Curcumin	0,8	STAT3	92,97	Curcumin	STAT3	MESH:D003474	6774	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|inhibition inhibition|compound|END_ENTITY	Curcumin suppresses vasculogenic mimicry capacity of hepatocellular_carcinoma cells through STAT3 and PI3K/AKT inhibition .
25337545	0	Curcumin	0,8	STAT3	18,23	Curcumin	STAT3	MESH:D003474	20848(Tax:10090)	Chemical	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	Curcumin Inhibits STAT3 Signaling in the Colon of Dextran Sulfate Sodium-treated Mice .
26815506	0	Curcumin	0,8	STAT3	69,74	Curcumin	STAT3	MESH:D003474	20848(Tax:10090)	Chemical	Gene	analogue|compound|START_ENTITY exhibits|nsubj|analogue exhibits|dobj|effect effect|nmod|END_ENTITY	Curcumin analogue , A13 , exhibits anti-leukemia effect via inhibiting STAT3 .
22156994	0	Curcumin	0,8	Stat3	18,23	Curcumin	Stat3	MESH:D003474	20848(Tax:10090)	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Curcumin : a novel Stat3 pathway inhibitor for chemoprevention of lung_cancer .
26677679	0	Curcumin	11,19	TGF-b2	23,29	Curcumin	TGF-b2	MESH:D003474	21808(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|Pathway Pathway|compound|END_ENTITY	-LSB- Effect of Curcumin on TGF-b2 Regulated PPAR-y/PDGF-b Signaling Pathway in Lung Fibroblasts of Mice -RSB- .
12515914	0	Curcumin	0,8	TGF-beta1	34,43	Curcumin	TGF-beta1	MESH:D003474	59086(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Curcumin differentially regulates TGF-beta1 , its receptors and nitric_oxide synthase during impaired wound healing .
21855605	0	Curcumin	0,8	TRPA1	131,136	Curcumin	TRPA1	MESH:D003474	8989	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Curcumin -LRB- -LRB- E , E -RRB- -1,7 - bis -LRB- 4-hydroxy-3-methoxyphenyl -RRB- -1,6 - heptadiene-3 ,5 - dione -RRB- activates and desensitizes the nociceptor ion channel TRPA1 .
20040737	0	Curcumin	0,8	TRPV1	63,68	Curcumin	TRPV1	MESH:D003474	7442	Chemical	Gene	produces|nsubj|START_ENTITY produces|dobj|effect effect|nmod|antagonism antagonism|nmod|END_ENTITY	Curcumin produces an antihyperalgesic effect via antagonism of TRPV1 .
18467956	0	Curcumin	0,8	VEGF	43,47	Curcumin	VEGF	MESH:D003474	7422	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|nmod|END_ENTITY	Curcumin inhibits MPA-induced secretion of VEGF from T47-D human breast_cancer cells .
21479462	0	Curcumin	0,8	VEGF	80,84	Curcumin	VEGF	MESH:D003474	7422	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|advcl|abrogating abrogating|dobj|expression expression|amod|END_ENTITY	Curcumin suppresses breast_tumor angiogenesis by abrogating osteopontin-induced VEGF expression .
21538854	0	Curcumin	0,8	VEGF	80,84	Curcumin	VEGF	MESH:D003474	22339(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|nmod|vascular_endothelial_growth_factor vascular_endothelial_growth_factor|appos|END_ENTITY	Curcumin reduces pulmonary_tumorigenesis in vascular_endothelial_growth_factor -LRB- VEGF -RRB- - overexpressing transgenic_mice .
21942294	0	Curcumin	0,8	VEGF	125,129	Curcumin	VEGF	MESH:D003474	7422	Chemical	Gene	heals|nsubj|START_ENTITY heals|nmod|stimulation stimulation|nmod|fibers fibers|nmod|END_ENTITY	Curcumin heals indomethacin-induced gastric_ulceration by stimulation of angiogenesis and restitution of collagen fibers via VEGF and MMP-2 mediated signaling .
26254223	0	Curcumin	0,8	VEGF	93,97	Curcumin	VEGF	MESH:D003474	22339(Tax:10090)	Chemical	Gene	inhibits|compound|START_ENTITY angiogenesis|nsubj|inhibits angiogenesis|dobj|hematopoiesis hematopoiesis|acl|induced induced|nmod|END_ENTITY	Curcumin inhibits angiogenesis and improves defective hematopoiesis induced by tumor-derived VEGF in tumor model through modulating VEGF-VEGFR2 signaling pathway .
26254223	0	Curcumin	0,8	VEGF	93,97	Curcumin	VEGF	MESH:D003474	22339(Tax:10090)	Chemical	Gene	inhibits|compound|START_ENTITY angiogenesis|nsubj|inhibits angiogenesis|dobj|hematopoiesis hematopoiesis|acl|induced induced|nmod|END_ENTITY	Curcumin inhibits angiogenesis and improves defective hematopoiesis induced by tumor-derived VEGF in tumor model through modulating VEGF-VEGFR2 signaling pathway .
22880132	0	Curcumin	0,8	Vps36	70,75	Curcumin	Vps36	MESH:D003474	851135(Tax:4932)	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|nmod|END_ENTITY	Curcumin prevents formation of polyglutamine aggregates by inhibiting Vps36 , a component of the ESCRT-II complex .
16490174	0	Curcumin	0,8	WT1	18,21	Curcumin	WT1	MESH:D003474	7490	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Curcumin inhibits WT1 gene expression in human leukemic K562 cells .
27026405	0	Curcumin	0,8	X-ray_repair_cross-complement_group_1	42,79	Curcumin	X-ray repair cross-complement group 1	MESH:D003474	7515	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|compound|END_ENTITY	Curcumin downregulates p38 MAPK-dependent X-ray_repair_cross-complement_group_1 -LRB- XRCC1 -RRB- expression to enhance cisplatin-induced cytotoxicity in human lung_cancer cells .
17583825	0	Curcumin	0,8	acid_sphingomyelinase	19,40	Curcumin	acid sphingomyelinase	MESH:D003474	6609	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|activity activity|amod|END_ENTITY	Curcumin decreases acid_sphingomyelinase activity in colon_cancer Caco-2 cells .
15037818	0	Curcumin	0,8	activator_protein_1	89,108	Curcumin	activator protein 1	MESH:D003474	16476(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	Curcumin suppresses lipopolysaccharide-induced cyclooxygenase-2 expression by inhibiting activator_protein_1 and nuclear factor kappab bindings in BV2 microglial cells .
18189141	0	Curcumin	0,8	alpha-synuclein	33,48	Curcumin	alpha-synuclein	MESH:D003474	6622	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|aggregation aggregation|nmod|END_ENTITY	Curcumin inhibits aggregation of alpha-synuclein .
20433710	0	Curcumin	0,8	alpha-synuclein	17,32	Curcumin	alpha-synuclein	MESH:D003474	6622	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	Curcumin reduces alpha-synuclein induced cytotoxicity in Parkinson 's _ disease cell model .
23735000	0	Curcumin	0,8	aquaporin-1	23,34	Curcumin	aquaporin-1	MESH:D003474	25240(Tax:10116)	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	Curcumin downregulates aquaporin-1 expression in cultured rat choroid plexus cells .
17880909	0	Curcumin	0,8	aryl_hydrocarbon_receptor	45,70	Curcumin	aryl hydrocarbon receptor	MESH:D003474	11622(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|transformation transformation|nmod|END_ENTITY	Curcumin suppresses the transformation of an aryl_hydrocarbon_receptor through its phosphorylation .
18420184	0	Curcumin	0,8	brain-derived_neurotrophic_factor	98,131	Curcumin	brain-derived neurotrophic factor	MESH:D003474	24225(Tax:10116)	Chemical	Gene	protects|nsubj|START_ENTITY protects|advcl|increasing increasing|dobj|level level|amod|END_ENTITY	Curcumin protects against glutamate excitotoxicity in rat cerebral cortical neurons by increasing brain-derived_neurotrophic_factor level and activating TrkB .
19879308	0	Curcumin	0,8	brain-derived_neurotrophic_factor	57,90	Curcumin	brain-derived neurotrophic factor	MESH:D003474	627	Chemical	Gene	produces|nsubj|START_ENTITY produces|dobj|effects effects|acl|activating activating|dobj|MAPK MAPK|amod|END_ENTITY	Curcumin produces neuroprotective effects via activating brain-derived_neurotrophic_factor / TrkB-dependent MAPK and PI-3K cascades in rodent cortical neurons .
17178109	0	Curcumin	0,8	calreticulin	88,100	Curcumin	calreticulin	MESH:D003474	100689096	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Curcumin enhances cystic fibrosis transmembrane regulator expression by down-regulating calreticulin .
22841393	0	Curcumin	0,8	cathelicidin_antimicrobial_peptide	23,57	Curcumin	cathelicidin antimicrobial peptide	MESH:D003474	820	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Curcumin induces human cathelicidin_antimicrobial_peptide gene expression through a vitamin_D_receptor-independent pathway .
16306131	0	Curcumin	0,8	connective_tissue_growth_factor	134,165	Curcumin	connective tissue growth factor	MESH:D003474	1490	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|nmod|genes genes|nmod|cells cells|acl|inhibiting inhibiting|dobj|expression expression|nmod|END_ENTITY	Curcumin suppresses the expression of extracellular matrix genes in activated hepatic stellate cells by inhibiting gene expression of connective_tissue_growth_factor .
17965732	0	Curcumin	0,8	connective_tissue_growth_factor	18,49	Curcumin	connective tissue growth factor	MESH:D003474	1490	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Curcumin inhibits connective_tissue_growth_factor gene expression in activated hepatic stellate cells in vitro by blocking NF-kappaB and ERK signalling .
10190560	0	Curcumin	0,8	cyclooxygenase-2	18,34	Curcumin	cyclooxygenase-2	MESH:D003474	5743	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|transcription transcription|amod|END_ENTITY	Curcumin inhibits cyclooxygenase-2 transcription in bile_acid - and phorbol_ester-treated human gastrointestinal epithelial cells .
12844482	0	Curcumin	0,8	cyclooxygenase-2	54,70	Curcumin	cyclooxygenase-2	MESH:D003474	19225(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Curcumin inhibits phorbol_ester-induced expression of cyclooxygenase-2 in mouse skin through suppression of extracellular_signal-regulated_kinase activity and NF-kappaB activation .
15037818	0	Curcumin	0,8	cyclooxygenase-2	47,63	Curcumin	cyclooxygenase-2	MESH:D003474	19225(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Curcumin suppresses lipopolysaccharide-induced cyclooxygenase-2 expression by inhibiting activator_protein_1 and nuclear factor kappab bindings in BV2 microglial cells .
20838026	0	Curcumin	0,8	cyclooxygenase-2	107,123	Curcumin	cyclooxygenase-2	MESH:D003474	5743	Chemical	Gene	Inhibits|nsubj|START_ENTITY Inhibits|advcl|suppressing suppressing|dobj|upregulation upregulation|amod|END_ENTITY	Curcumin Inhibits the proteinase-activated_receptor-2-triggered prostaglandin_E2 production by suppressing cyclooxygenase-2 upregulation and Akt-dependent activation of nuclear factor-kB in human lung epithelial cells .
21437112	0	Curcumin	0,8	cyclooxygenase-2	83,99	Curcumin	cyclooxygenase-2	MESH:D003474	29527(Tax:10116)	Chemical	Gene	improves|nsubj|START_ENTITY improves|nmod|arteries arteries|acl|associated associated|nmod|suppression suppression|amod|END_ENTITY	Curcumin improves prostanoid ratio in diabetic mesenteric arteries associated with cyclooxygenase-2 and NF-kB suppression .
23494805	0	Curcumin	0,8	cyclooxygenase-2	20,36	Curcumin	cyclooxygenase-2	MESH:D003474	5743	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|amod|END_ENTITY	Curcumin attenuates cyclooxygenase-2 expression via inhibition of the NF-kB pathway in lipopolysaccharide-stimulated human gingival fibroblasts .
24534491	0	Curcumin	0,8	delta-like_homolog_1	19,39	Curcumin	delta-like homolog 1	MESH:D003474	114587(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Curcumin regulates delta-like_homolog_1 expression in activated hepatic stellate cell .
25333322	0	Curcumin	0,8	elastin	83,90	Curcumin	elastin	MESH:D003474	2006	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|amod|END_ENTITY	Curcumin enhances the production of major structural components of elastic fibers , elastin , and fibrillin-1 , in normal human fibroblast cells .
10851300	2	Curcumin	64,72	epidermal_growth_factor_receptor	110,142	Curcumin	epidermal growth factor receptor	MESH:D003474	1956	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	Curcumin inhibits tyrosine kinase activity of epidermal_growth_factor_receptor and depletes the protein .
23660191	0	Curcumin	0,8	glucagon-like_peptide-1	20,43	Curcumin	glucagon-like peptide-1	MESH:D003474	2641	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|amod|END_ENTITY	Curcumin stimulates glucagon-like_peptide-1 secretion in GLUTag cells via Ca2 + / calmodulin-dependent kinase II activation .
17449203	0	Curcumin	0,8	glutathione_S-transferase_P1	25,53	Curcumin	glutathione S-transferase P1	MESH:D003474	2950	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|amod|END_ENTITY	Curcumin activates human glutathione_S-transferase_P1 expression through antioxidant response element .
22101212	0	Curcumin	0,8	hERG	18,22	Curcumin	hERG	MESH:D003474	2078	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Curcumin inhibits hERG potassium channels in vitro .
12570874	0	Curcumin	0,8	haem_oxygenase-1	23,39	Curcumin	haem oxygenase-1	MESH:D003474	3162	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|gene gene|amod|END_ENTITY	Curcumin activates the haem_oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element .
18006204	0	Curcumin	0,8	heme_oxygenase-1	104,120	Curcumin	heme oxygenase-1	MESH:D003474	24451(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|nmod|induction induction|nmod|END_ENTITY	Curcumin attenuates dimethylnitrosamine-induced liver_injury in rats through Nrf2-mediated induction of heme_oxygenase-1 .
20080166	0	Curcumin	0,8	heme_oxygenase-1	75,91	Curcumin	heme oxygenase-1	MESH:D003474	24451(Tax:10116)	Chemical	Gene	alleviates|nsubj|START_ENTITY alleviates|dobj|damage damage|nmod|induction induction|amod|END_ENTITY	Curcumin alleviates ethanol-induced hepatocytes oxidative damage involving heme_oxygenase-1 induction .
20938987	0	Curcumin	0,8	heme_oxygenase-1	17,33	Curcumin	heme oxygenase-1	MESH:D003474	3162	Chemical	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Curcumin induces heme_oxygenase-1 in normal human skin fibroblasts through redox signaling : relevance for anti-aging intervention .
22392462	0	Curcumin	0,8	heme_oxygenase-1	93,109	Curcumin	heme oxygenase-1	MESH:D003474	3162	Chemical	Gene	ameliorates|nsubj|START_ENTITY ameliorates|advcl|upregulating upregulating|dobj|expression expression|amod|END_ENTITY	Curcumin ameliorates hydrogen_peroxide-induced epithelial barrier disruption by upregulating heme_oxygenase-1 expression in human intestinal epithelial cells .
22539869	0	Curcumin	0,8	heme_oxygenase-1	93,109	Curcumin	heme oxygenase-1	MESH:D003474	3162	Chemical	Gene	protects|nsubj|START_ENTITY protects|dobj|cells cells|nmod|stress stress|nmod|induction induction|nmod|expression expression|amod|END_ENTITY	Curcumin protects retinal pigment epithelial cells against oxidative stress via induction of heme_oxygenase-1 expression and reduction of reactive oxygen .
22922731	0	Curcumin	0,8	heme_oxygenase-1	50,66	Curcumin	heme oxygenase-1	MESH:D003474	3162	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|induction induction|nmod|END_ENTITY	Curcumin inhibits HCV replication by induction of heme_oxygenase-1 and suppression of AKT .
23494637	0	Curcumin	0,8	heme_oxygenase-1	96,112	Curcumin	heme oxygenase-1	MESH:D003474	24451(Tax:10116)	Chemical	Gene	ameliorates|nsubj|START_ENTITY ameliorates|nmod|cells cells|amod|hypoxia hypoxia|advcl|upregulating upregulating|dobj|expression expression|amod|END_ENTITY	Curcumin ameliorates the permeability of the blood-brain barrier during hypoxia by upregulating heme_oxygenase-1 expression in brain microvascular endothelial cells .
23710741	0	Curcumin	1,9	heme_oxygenase-1	66,82	Curcumin	heme oxygenase-1	MESH:D003474	24451(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|advcl|upregulating upregulating|dobj|expression expression|amod|END_ENTITY	-LSB- Curcumin attenuates contrast-induced_nephropathy by upregulating heme_oxygenase-1 expression in rat -RSB- .
23977989	0	Curcumin	0,8	heme_oxygenase-1	108,124	Curcumin	heme oxygenase-1	MESH:D003474	3162	Chemical	Gene	ameliorates|nsubj|START_ENTITY ameliorates|dobj|expression expression|nmod|induction induction|nmod|cells cells|amod|END_ENTITY	Curcumin ameliorates TNF-a-induced ICAM-1 expression and subsequent THP-1 adhesiveness via the induction of heme_oxygenase-1 in the HaCaT cells .
25823828	0	Curcumin	0,8	heme_oxygenase-1	150,166	Curcumin	heme oxygenase-1	MESH:D003474	24451(Tax:10116)	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|upregulation upregulation|nmod|END_ENTITY	Curcumin protects renal tubular epithelial cells from high glucose-induced epithelial-to-mesenchymal transition through Nrf2-mediated upregulation of heme_oxygenase-1 .
25891083	0	Curcumin	0,8	heme_oxygenase-1	64,80	Curcumin	heme oxygenase-1	MESH:D003474	3162	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|apoptosis apoptosis|acl|upregulating upregulating|dobj|expression expression|amod|END_ENTITY	Curcumin inhibits appoptosin-induced apoptosis via upregulating heme_oxygenase-1 expression in SH-SY5Y cells .
16221204	0	Curcumin	0,8	heme_oxygenase_1	83,99	Curcumin	heme oxygenase 1	MESH:D003474	24451(Tax:10116)	Chemical	Gene	blocks|nsubj|START_ENTITY blocks|nmod|up-regulation up-regulation|nmod|END_ENTITY	Curcumin blocks fibrosis in anti-Thy_1 glomerulonephritis through up-regulation of heme_oxygenase_1 .
17143561	0	Curcumin	0,8	heme_oxygenase_1	17,33	Curcumin	heme oxygenase 1	MESH:D003474	3162	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Curcumin induces heme_oxygenase_1 through generation of reactive oxygen species , p38 activation and phosphatase inhibition .
24606484	0	Curcumin	0,8	inhibitor_of_DNA_binding_1	32,58	Curcumin	inhibitor of DNA binding 1	MESH:D003474	3397	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Curcumin inhibits expression of inhibitor_of_DNA_binding_1 in PC3 cells and xenografts .
21695461	0	Curcumin	0,8	intercellular_adhesion_molecule-1	91,124	Curcumin	intercellular adhesion molecule-1	MESH:D003474	15894(Tax:10090)	Chemical	Gene	protects|nsubj|START_ENTITY protects|advcl|inhibiting inhibiting|dobj|END_ENTITY	Curcumin protects mice against concanavalin A-induced hepatitis by inhibiting intrahepatic intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- and CXCL10 expression .
17000667	0	Curcumin	0,8	interleukin-8	39,52	Curcumin	interleukin-8	MESH:D003474	3576	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Curcumin inhibits neurotensin-mediated interleukin-8 production and migration of HCT116 human colon_cancer cells .
12216086	0	Curcumin	0,8	interleukin_8	18,31	Curcumin	interleukin 8	MESH:D003474	3576	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Curcumin inhibits interleukin_8 production and enhances interleukin_8 receptor expression on the cell surface : impact on human pancreatic_carcinoma cell growth by autocrine regulation .
20163327	0	Curcumin	0,8	lectin-like_oxidised_LDL_receptor-1	35,70	Curcumin	lectin-like oxidised LDL receptor-1	MESH:D003474	4973	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Curcumin inhibits TNFalpha-induced lectin-like_oxidised_LDL_receptor-1 -LRB- LOX-1 -RRB- expression and suppresses the inflammatory response in human umbilical vein endothelial cells -LRB- HUVECs -RRB- by an antioxidant mechanism .
25866478	0	Curcumin	0,8	leptin	18,24	Curcumin	leptin	MESH:D003474	3952	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Curcumin inhibits leptin gene expression and secretion in breast_cancer cells by estrogen receptors .
24926361	0	Curcumin	0,8	matrix_metalloproteinase-2	52,78	Curcumin	matrix metalloproteinase-2	MESH:D003474	81686(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Curcumin suppresses tumor_necrosis_factor-a-induced matrix_metalloproteinase-2 expression and activity in rat vascular smooth muscle cells via the NF-kB pathway .
16102725	0	Curcumin	0,8	matrix_metalloproteinase-9	42,68	Curcumin	matrix metalloproteinase-9	MESH:D003474	4318	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Curcumin suppresses phorbol_ester-induced matrix_metalloproteinase-9 expression by inhibiting the PKC to MAPK signaling pathways in human astroglioma cells .
19374255	0	Curcumin	0,8	matrix_metalloproteinase-9	52,78	Curcumin	matrix metalloproteinase-9	MESH:D003474	17395(Tax:10090)	Chemical	Gene	arrests|compound|START_ENTITY endometriosis|nsubj|arrests endometriosis|nmod|downregulation downregulation|nmod|activity activity|amod|END_ENTITY	Curcumin arrests endometriosis by downregulation of matrix_metalloproteinase-9 activity .
9663426	0	Curcumin	0,8	matrix_metalloproteinase-9	90,116	Curcumin	matrix metalloproteinase-9	MESH:D003474	4318	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|invasion invasion|nmod|secretion secretion|amod|END_ENTITY	Curcumin inhibits SK-Hep-1 hepatocellular_carcinoma cell invasion in vitro and suppresses matrix_metalloproteinase-9 secretion .
20815812	0	Curcumin	0,8	miR-21	19,25	Curcumin	miR-21	MESH:D003474	406991	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Curcumin regulates miR-21 expression and inhibits invasion and metastasis in colorectal_cancer .
26116834	0	Curcumin	0,8	miR-21	123,129	Curcumin	miR-21	MESH:D003474	406991	Chemical	Gene	inhibits|compound|START_ENTITY inhibits|dep|role role|nmod|disposal disposal|nmod|END_ENTITY	Curcumin inhibits in vitro and in vivo chronic myelogenous_leukemia cells growth : a possible role for exosomal disposal of miR-21 .
27050372	0	Curcumin	0,8	miR-21	116,122	Curcumin	miR-21	MESH:D003474	406991	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|ccomp|composition composition|dobj|phenotype phenotype|nmod|END_ENTITY	Curcumin modulates chronic_myelogenous_leukemia exosomes composition and affects angiogenic phenotype , via exosomal miR-21 .
16081677	0	Curcumin	0,8	microsomal_prostaglandin_E_synthase_1	47,84	Curcumin	microsomal prostaglandin E synthase 1	MESH:D003474	9536	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	Curcumin suppresses interleukin 1beta-mediated microsomal_prostaglandin_E_synthase_1 by altering early_growth_response_gene_1 and other signaling pathways .
11967955	0	Curcumin	0,8	p21	95,98	Curcumin	p21	MESH:D003474	1026	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|advcl|inducing inducing|dobj|END_ENTITY	Curcumin enhances cytotoxicity of chemotherapeutic agents in prostate_cancer cells by inducing p21 -LRB- WAF1/CIP1 -RRB- and C/EBPbeta expressions and suppressing NF-kappaB activation .
17240359	0	Curcumin	0,8	p21	144,147	Curcumin	p21	MESH:D003474	1026	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|pathway pathway|amod|END_ENTITY	Curcumin induces the degradation of cyclin E expression through ubiquitin-dependent pathway and up-regulates cyclin-dependent kinase inhibitors p21 and p27 in multiple human tumor cell lines .
21633290	0	Curcumin	0,8	p21	51,54	Curcumin	p21	MESH:D003474	12575(Tax:10090)	Chemical	Gene	stimulate|nsubj|START_ENTITY stimulate|dobj|END_ENTITY	Curcumin and resveratrol synergistically stimulate p21 and regulate cox-2 by maintaining adequate zinc levels during lung_carcinogenesis .
26531053	0	Curcumin	0,8	p21	88,91	Curcumin	p21	MESH:D003474	644914	Chemical	Gene	improves|nsubj|START_ENTITY improves|advcl|targeting targeting|nmod|END_ENTITY	Curcumin improves the efficacy of cisplatin by targeting cancer stem-like cells through p21 and cyclin_D1-mediated tumour cell inhibition in non-small_cell_lung_cancer cell lines .
26985469	0	Curcumin	24,32	p21	168,171	Curcumin	p21	MESH:D003474	644914	Chemical	Gene	notice|nmod|START_ENTITY induces|dep|notice induces|nmod|pathway pathway|amod|END_ENTITY	Retraction notice to Curcumin induces the degradation of cyclin E expression through ubiquitin-dependent pathway and up-regulates cyclin-dependent kinase inhibitors p21 and p27 in multiple human tumor cell lines -LSB- Biochem .
23352975	0	Curcumin	0,8	p38	48,51	Curcumin	p38	MESH:D003474	1432	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|amod|END_ENTITY	Curcumin induces FasL-related apoptosis through p38 activation in human hepatocellular_carcinoma Huh7 cells .
27026405	0	Curcumin	0,8	p38	23,26	Curcumin	p38	MESH:D003474	1432	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	Curcumin downregulates p38 MAPK-dependent X-ray_repair_cross-complement_group_1 -LRB- XRCC1 -RRB- expression to enhance cisplatin-induced cytotoxicity in human lung_cancer cells .
24926560	0	Curcumin	0,8	p38_mitogen-activated_protein_kinase	65,101	Curcumin	p38 mitogen-activated protein kinase	MESH:D003474	1432	Chemical	Gene	increases|nsubj|START_ENTITY increases|nmod|END_ENTITY	Curcumin increases gelatinase activity in human neutrophils by a p38_mitogen-activated_protein_kinase -LRB- MAPK -RRB- - independent mechanism .
11716543	0	Curcumin	0,8	p53	107,110	Curcumin	p53	MESH:D003474	7157	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|-8 -8|nmod|END_ENTITY	Curcumin induces apoptosis in human melanoma cells through a Fas receptor/caspase -8 pathway independent of p53 .
15090465	0	Curcumin	0,8	p53	34,37	Curcumin	p53	MESH:D003474	7157	Chemical	Gene	impairs|nsubj|START_ENTITY impairs|dobj|function function|compound|END_ENTITY	Curcumin impairs tumor suppressor p53 function in colon_cancer cells .
16302093	0	Curcumin	0,8	p53	79,82	Curcumin	p53	MESH:D003474	7157	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|activating activating|dobj|END_ENTITY	Curcumin induces human HT-29 colon_adenocarcinoma cell apoptosis by activating p53 and regulating apoptosis-related protein expression .
25860911	0	Curcumin	20,28	p53	65,68	Curcumin	p53	MESH:D003474	22060(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Long Term Effect of Curcumin in Restoration of Tumour Suppressor p53 and Phase-II Antioxidant Enzymes via Activation of Nrf2 Signalling and Modulation of Inflammation in Prevention of Cancer .
21078213	0	Curcumin	0,8	paraoxonase_1	17,30	Curcumin	paraoxonase 1	MESH:D003474	18979(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Curcumin induces paraoxonase_1 in cultured hepatocytes in vitro but not in mouse liver in vivo .
19644570	0	Curcumin	0,8	peroxisome_proliferator-activated_receptor-y	29,73	Curcumin	peroxisome proliferator-activated receptor-y	MESH:D003474	5468	Chemical	Gene	ligand|nsubj|START_ENTITY ligand|advcl|shown shown|nsubjpass|Curcumin Curcumin|amod|END_ENTITY	Curcumin is not a ligand for peroxisome_proliferator-activated_receptor-y Curcumin , a compound found in the spice turmeric , has been shown to possess a number of beneficial biological activities exerted through a variety of different mechanisms .
25445048	0	Curcumin	0,8	peroxisome_proliferator-activated_receptor-y	19,63	Curcumin	peroxisome proliferator-activated receptor-y	MESH:D003474	5468	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Curcumin regulates peroxisome_proliferator-activated_receptor-y coactivator-1a expression by AMPK pathway in hepatic stellate cells in vitro .
16782535	0	Curcumin	0,8	peroxisome_proliferator-activated_receptor_gamma	90,138	Curcumin	peroxisome proliferator-activated receptor gamma	MESH:D003474	25664(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|activation activation|nmod|END_ENTITY	Curcumin inhibits trinitrobenzene_sulphonic_acid-induced colitis in rats by activation of peroxisome_proliferator-activated_receptor_gamma .
7511111	0	Curcumin	0,8	phosphorylase_kinase	57,77	Curcumin	phosphorylase kinase	MESH:D003474	5256	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Curcumin is a non-competitive and selective inhibitor of phosphorylase_kinase .
24144778	0	Curcumin	0,8	pre-mRNA_processing_factor_4	86,114	Curcumin	pre-mRNA processing factor 4	MESH:D003474	9128	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|modulating modulating|dobj|END_ENTITY	Curcumin induces radiosensitivity of in vitro and in vivo cancer models by modulating pre-mRNA_processing_factor_4 -LRB- Prp4 -RRB- .
18719352	0	Curcumin	0,8	receptor_activator_of_nuclear_factor-kappaB_ligand	51,101	Curcumin	receptor activator of nuclear factor-kappaB ligand	MESH:D003474	8600	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Curcumin inhibits osteoclastogenesis by decreasing receptor_activator_of_nuclear_factor-kappaB_ligand -LRB- RANKL -RRB- in bone marrow stromal cells .
19808779	0	Curcumin	0,8	srebp-2	18,25	Curcumin	srebp-2	MESH:D003474	6721	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Curcumin inhibits srebp-2 expression in activated hepatic stellate cells in vitro by reducing the activity of specificity_protein-1 .
12745871	0	Curcumin	0,8	sulfotransferase	41,57	Curcumin	sulfotransferase	MESH:D003474	6818	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Curcumin is a potent inhibitor of phenol sulfotransferase -LRB- SULT1A1 -RRB- in human liver and extrahepatic tissues .
20599422	0	Curcumin	0,8	toll-like_receptor-2	19,39	Curcumin	toll-like receptor-2	MESH:D003474	7097	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|amod|END_ENTITY	Curcumin decreases toll-like_receptor-2 gene expression and function in human monocytes and neutrophils .
9586949	0	Curcumin	0,8	tumor_necrosis_factor	43,64	Curcumin	tumor necrosis factor	MESH:D003474	7124	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Curcumin -LRB- Diferuloylmethane -RRB- inhibition of tumor_necrosis_factor -LRB- TNF -RRB- - mediated adhesion of monocytes to endothelial cells by suppression of cell surface expression of adhesion molecules and of nuclear factor-kappaB activation .
23083815	0	Curcumin	0,8	tumor_necrosis_factor-a	44,67	Curcumin	tumor necrosis factor-a	MESH:D003474	7124	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|lipolysis lipolysis|acl|stimulated stimulated|nmod|END_ENTITY	Curcumin attenuates lipolysis stimulated by tumor_necrosis_factor-a or isoproterenol in 3T3-L1 adipocytes .
27025786	0	Curcumin	0,8	tumor_necrosis_factor-a	29,52	Curcumin	tumor necrosis factor-a	MESH:D003474	7124	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|levels levels|amod|END_ENTITY	Curcumin downregulates human tumor_necrosis_factor-a levels : A systematic review and meta-analysis ofrandomized controlled trials .
21538854	0	Curcumin	0,8	vascular_endothelial_growth_factor	44,78	Curcumin	vascular endothelial growth factor	MESH:D003474	22339(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|nmod|END_ENTITY	Curcumin reduces pulmonary_tumorigenesis in vascular_endothelial_growth_factor -LRB- VEGF -RRB- - overexpressing transgenic_mice .
20461157	0	Curcuminoids	0,12	thioredoxin_reductase	30,51	Curcuminoids	thioredoxin reductase	null	25824	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Curcuminoids as inhibitors of thioredoxin_reductase : a receptor based pharmacophore study with distance mapping of the active site .
19218461	4	Cx32	737,741	Nrg1	711,715	Cx32	Nrg1	MESH:C576660	211323(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Primary cultures of purified SCs from newborn mouse sciatic nerve were used to characterize both the role of Nrg1 in the expression of Cx32 and , conversely , the role of Cx32 in SC responsiveness to Nrg1 .
10379628	0	Cyanamide	0,9	catalase	24,32	Cyanamide	catalase	MESH:D003484	12359(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	Cyanamide reduces brain catalase and ethanol-induced locomotor activity : is there a functional link ?
21838543	0	Cyanate	0,7	icam-1	42,48	Cyanate	icam-1	CHEBI:29195	3383	Chemical	Gene	inducer|nsubj|START_ENTITY inducer|nmod|expression expression|amod|END_ENTITY	Cyanate is a novel inducer of endothelial icam-1 expression .
22427114	0	Cyanate	0,7	insulin	19,26	Cyanate	insulin	CHEBI:29195	3630	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|secretion secretion|compound|END_ENTITY	Cyanate attenuates insulin secretion in cultured pancreatic b cells .
2550034	0	Cyanide	0,7	myeloperoxidase	26,41	Cyanide	myeloperoxidase	CHEBI:17514	4353	Chemical	Gene	START_ENTITY|xcomp|binding binding|nmod|END_ENTITY	Cyanide binding to canine myeloperoxidase .
20096264	0	Cyanidin	0,8	COX-2	42,47	Cyanidin	COX-2	MESH:C017154	5743	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Cyanidin suppresses ultraviolet B-induced COX-2 expression in epidermal cells by targeting MKK4 , MEK1 , and Raf-1 .
18619979	0	Cyanidin-3-O-beta-glucoside	0,27	iNOS	37,41	Cyanidin-3-O-beta-glucoside	iNOS	MESH:C114438	4843	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Cyanidin-3-O-beta-glucoside inhibits iNOS and COX-2 expression by inducing liver X receptor alpha activation in THP-1 macrophages .
20494459	0	Cyclic-AMP	0,10	CREB	45,49	Cyclic-AMP	CREB	MESH:D000242	1385	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Cyclic-AMP response element binding protein -LRB- CREB -RRB- in the neutrophils of depressed patients .
11689885	0	Cyclic_ADP-ribose	0,17	CD38	32,36	Cyclic ADP-ribose	CD38	MESH:D036563	952	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Cyclic_ADP-ribose production by CD38 regulates intracellular calcium release , extracellular calcium influx and chemotaxis in neutrophils and is required for bacterial clearance in vivo .
12475890	0	Cyclic_ADP-ribose	0,17	CD38	32,36	Cyclic ADP-ribose	CD38	MESH:D036563	952	Chemical	Gene	generation|amod|START_ENTITY generation|nmod|END_ENTITY	Cyclic_ADP-ribose generation by CD38 improves human hemopoietic stem cell engraftment into NOD/SCID mice .
21740519	0	Cyclic_ADP-ribose	0,17	CD38	27,31	Cyclic ADP-ribose	CD38	MESH:D036563	12494(Tax:10090)	Chemical	Gene	requires|nsubj|START_ENTITY requires|dobj|END_ENTITY	Cyclic_ADP-ribose requires CD38 to regulate the release of ATP in visceral smooth muscle .
11278269	0	Cyclic_AMP	0,10	Akt	20,23	Cyclic AMP	Akt	MESH:D000242	207	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	Cyclic_AMP inhibits Akt activity by blocking the membrane localization of PDK1 .
12753285	0	Cyclic_AMP	0,10	B-Raf	21,26	Cyclic AMP	B-Raf	MESH:D000242	673	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Cyclic_AMP activates B-Raf and ERK in cyst epithelial cells from autosomal-dominant_polycystic_kidneys .
15278365	0	Cyclic_AMP	0,10	B-Raf	147,152	Cyclic AMP	B-Raf	MESH:D000242	673	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|ERK ERK|acl|activation activation|advcl|pattern pattern|nmod|END_ENTITY	Cyclic_AMP differentially regulates cell proliferation of normal human keratinocytes through ERK activation depending on the expression pattern of B-Raf .
8383817	0	Cyclic_AMP	0,10	CA1	45,48	Cyclic AMP	CA1	MESH:D000242	310218(Tax:10116)	Chemical	Gene	potentiation|amod|START_ENTITY potentiation|nmod|region region|compound|END_ENTITY	Cyclic_AMP and long-term potentiation in the CA1 region of rat hippocampus .
1827668	0	Cyclic_AMP	0,10	CRE-BP1	45,52	Cyclic AMP	CRE-BP1	MESH:D000242	1386	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Cyclic_AMP response element-binding protein , CRE-BP1 , mediates the E1A-induced but not the Tax-induced trans-activation .
11345520	0	Cyclic_AMP	0,10	CREB	45,49	Cyclic AMP	CREB	MESH:D000242	81646(Tax:10116)	Chemical	Gene	element|amod|START_ENTITY element|dep|protein protein|appos|END_ENTITY	Cyclic_AMP response element binding protein -LRB- CREB -RRB- and CREB_binding_protein -LRB- CBP -RRB- in global cerebral_ischemia .
12956721	0	Cyclic_AMP	0,10	CREB	37,41	Cyclic AMP	CREB	MESH:D000242	1385	Chemical	Gene	element-binding|amod|START_ENTITY element-binding|appos|END_ENTITY	Cyclic_AMP response element-binding -LRB- CREB -RRB- - like proteins in a molluscan brain : cellular localization and learning-induced phosphorylation .
16878996	0	Cyclic_AMP	0,10	CREB	45,49	Cyclic AMP	CREB	MESH:D000242	1385	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Cyclic_AMP response element-binding protein -LRB- CREB -RRB- and CAAT/enhancer-binding _ protein beta -LRB- C/EBPbeta -RRB- bind chimeric DNA sites with high affinity .
22119240	0	Cyclic_AMP	0,10	CREB	45,49	Cyclic AMP	CREB	MESH:D000242	1385	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	Cyclic_AMP response element-binding protein -LRB- CREB -RRB- phosphorylation : a mechanistic marker in the development of memory enhancing Alzheimer 's _ disease therapeutics .
24257117	0	Cyclic_AMP	0,10	CREB	37,41	Cyclic AMP	CREB	MESH:D000242	1385	Chemical	Gene	element|amod|START_ENTITY element|dep|acts acts|amod|binding binding|dep|END_ENTITY	Cyclic_AMP response element binding -LRB- CREB -RRB- protein acts as a positive regulator of SOX3 gene expression in NT2/D1 cells .
2573431	0	Cyclic_AMP	0,10	CREB	76,80	Cyclic AMP	CREB	MESH:D000242	81646(Tax:10116)	Chemical	Gene	stimulates|amod|START_ENTITY somatostatin|nsubj|stimulates somatostatin|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Cyclic_AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133 .
8336722	0	Cyclic_AMP	147,157	CREB	88,92	Cyclic AMP	CREB	MESH:D000242	1385	Chemical	Gene	regulates|nsubj|START_ENTITY Coupling|acl:relcl|regulates Coupling|nmod|factor factor|acl:relcl|limited limited|nsubj|END_ENTITY	Coupling of hormonal stimulation and transcription via the cyclic_AMP-responsive factor CREB is rate limited by nuclear entry of protein kinase A. Cyclic_AMP -LRB- cAMP -RRB- regulates a number of eukaryotic genes by mediating the protein kinase A -LRB- PKA -RRB- - dependent phosphorylation of the CREB transcription factor at Ser-133 .
9247115	0	Cyclic_AMP	0,10	CREB	64,68	Cyclic AMP	CREB	MESH:D000242	1385	Chemical	Gene	signalling|amod|START_ENTITY signalling|dep|regulation regulation|nmod|END_ENTITY	Cyclic_AMP signalling and cellular proliferation : regulation of CREB and CREM .
9685213	0	Cyclic_AMP	0,10	CREB	141,145	Cyclic AMP	CREB	MESH:D000242	1385	Chemical	Gene	differentiation|amod|START_ENTITY differentiation|dep|involvement involvement|nmod|END_ENTITY	Cyclic_AMP potentiates growth_hormone-dependent differentiation of 3T3-F442A preadipocytes : possible involvement of the transcription factor CREB .
24231725	0	Cyclic_AMP	0,10	EPAC	18,22	Cyclic AMP	EPAC	MESH:D000242	10411	Chemical	Gene	START_ENTITY|dobj|proteins proteins|compound|END_ENTITY	Cyclic_AMP sensor EPAC proteins and energy homeostasis .
26941424	0	Cyclic_AMP	0,10	EPAC	18,22	Cyclic AMP	EPAC	MESH:D000242	10411	Chemical	Gene	START_ENTITY|dobj|Proteins Proteins|compound|END_ENTITY	Cyclic_AMP Sensor EPAC Proteins and Their Role in Cardiovascular Function and Disease .
15278365	0	Cyclic_AMP	0,10	ERK	93,96	Cyclic AMP	ERK	MESH:D000242	5594	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Cyclic_AMP differentially regulates cell proliferation of normal human keratinocytes through ERK activation depending on the expression pattern of B-Raf .
15078890	0	Cyclic_AMP	0,10	ERK1/2	180,186	Cyclic AMP	ERK1/2	MESH:D000242	5595;5594	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Cyclic_AMP promotes cAMP-responsive element-binding protein-dependent induction of cellular_inhibitor_of_apoptosis_protein-2 and suppresses apoptosis of colon_cancer cells through ERK1/2 and p38 MAPK .
12578910	0	Cyclic_AMP	0,10	Epac	59,63	Cyclic AMP	Epac	MESH:D000242	10411	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Cyclic_AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the beta 2-adrenergic receptor .
18391018	0	Cyclic_AMP	0,10	Epac	103,107	Cyclic AMP	Epac	MESH:D000242	10411	Chemical	Gene	START_ENTITY|dep|stimulation stimulation|nmod|differentiation differentiation|acl:relcl|requires requires|dobj|action action|nmod|END_ENTITY	Cyclic_AMP -LRB- cAMP -RRB- - mediated stimulation of adipocyte differentiation requires the synergistic action of Epac - and cAMP-dependent protein kinase-dependent processes .
6244345	0	Cyclic_AMP	0,10	Fc_receptor	25,36	Cyclic AMP	Fc receptor	MESH:D000242	338062(Tax:9913)	Chemical	Gene	modulation|amod|START_ENTITY modulation|nmod|expression expression|compound|END_ENTITY	Cyclic_AMP modulation of Fc_receptor expression on a pre-B cell lymphoma .
12210727	0	Cyclic_AMP	0,10	GSTP1	20,25	Cyclic AMP	GSTP1	MESH:D000242	2950	Chemical	Gene	activation|amod|START_ENTITY activation|compound|END_ENTITY	Cyclic_AMP mediated GSTP1 gene activation in tumor cells involves the interaction of activated CREB-1 with the GSTP1 CRE : a novel mechanism of cellular GSTP1 gene regulation .
19481766	0	Cyclic_AMP	0,10	IL-1beta	20,28	Cyclic AMP	IL-1beta	MESH:D000242	3553	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Cyclic_AMP inhibits IL-1beta plus IFNgamma-induced NF-kappaB translocation in hepatocytes by a PKA independent mechanism .
1848580	0	Cyclic_AMP	0,10	IL-2_receptor	29,42	Cyclic AMP	IL-2 receptor	MESH:D000242	3560	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Cyclic_AMP directly inhibits IL-2_receptor expression in human T cells : expression of both p55 and p75 subunits is affected .
16793321	0	Cyclic_AMP	0,10	MEG3	22,26	Cyclic AMP	MEG3	MESH:D000242	55384	Chemical	Gene	stimulates|amod|START_ENTITY END_ENTITY|nsubj|stimulates	Cyclic_AMP stimulates MEG3 gene expression in cells through a cAMP-response element -LRB- CRE -RRB- in the MEG3 proximal promoter region .
20203059	0	Cyclic_AMP	0,10	Mrp2	22,26	Cyclic AMP	Mrp2	MESH:D000242	25303(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|translocation translocation|amod|END_ENTITY	Cyclic_AMP stimulates Mrp2 translocation by activating p38 -LCB- alpha -RCB- MAPK in hepatic cells .
7925490	0	Cyclic_AMP	0,10	NCAM	21,25	Cyclic AMP	NCAM	MESH:D000242	17967(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Cyclic_AMP regulates NCAM expression and phosphorylation in cultured mouse astrocytes .
19481766	0	Cyclic_AMP	0,10	NF-kappaB	51,60	Cyclic AMP	NF-kappaB	MESH:D000242	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|IL-1beta IL-1beta|nmod|translocation translocation|amod|END_ENTITY	Cyclic_AMP inhibits IL-1beta plus IFNgamma-induced NF-kappaB translocation in hepatocytes by a PKA independent mechanism .
17586635	0	Cyclic_AMP	0,10	NasP	30,34	Cyclic AMP	NasP	MESH:D000242	4678	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Cyclic_AMP directly activates NasP , an N-acyl_amino_acid antibiotic biosynthetic enzyme cloned from an uncultured beta-proteobacterium .
16888226	0	Cyclic_AMP	0,10	PACAP	51,56	Cyclic AMP	PACAP	MESH:D000242	116	Chemical	Gene	formation|amod|START_ENTITY formation|dep|effect effect|nmod|END_ENTITY	Cyclic_AMP formation in C6_glioma cells : effect of PACAP and VIP in early and late passages .
8710181	0	Cyclic_AMP	0,10	PACAP	67,72	Cyclic AMP	PACAP	MESH:D000242	24166(Tax:10116)	Chemical	Gene	polypeptide|amod|START_ENTITY polypeptide|appos|END_ENTITY	Cyclic_AMP and pituitary adenylate cyclase-activating polypeptide -LRB- PACAP -RRB- prevent programmed cell death of cultured rat cerebellar granule cells .
16413017	0	Cyclic_AMP	0,10	RFC40	65,70	Cyclic AMP	RFC40	MESH:D000242	5982	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|translocation translocation|nmod|END_ENTITY	Cyclic_AMP regulates the expression and nuclear translocation of RFC40 in MCF7 cells .
18487435	0	Cyclic_AMP	0,10	Rap1	24,28	Cyclic AMP	Rap1	MESH:D000242	5906	Chemical	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	Cyclic_AMP acts through Rap1 and JNK signaling to increase expression of cutaneous smooth muscle alpha2C-adrenoceptors .
25713071	0	Cyclic_AMP	0,10	Sirtuin_6	29,38	Cyclic AMP	sirtuin 6	MESH:D000242	51548	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Cyclic_AMP Signaling Reduces Sirtuin_6 Expression in Non-small_Cell_Lung_Cancer Cells by Promoting Ubiquitin-Proteasomal Degradation via Inhibition of the Raf-MEK-ERK Pathway .
23349840	0	Cyclic_AMP	0,10	TGFb	20,24	Cyclic AMP	TGFb	MESH:D000242	7040	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|responses responses|compound|END_ENTITY	Cyclic_AMP enhances TGFb responses of breast_cancer cells by upregulating TGFb receptor I expression .
22865690	4	Cyclic_AMP	803,813	TNF-a	783,788	Cyclic AMP	TNF-a	MESH:D000242	7124	Chemical	Gene	suppressed|nmod|START_ENTITY suppressed|nmod|END_ENTITY	TNF-a or IL-1b stimulation produced a profound reduction -LRB- > 90 % -RRB- of cyclic_AMP within EOC2 microglia from 30 min that then recovered after IL-1b but remained suppressed with TNF-a through 24 h. Cyclic_AMP was also reduced in TNF-a-stimulated primary microglia , albeit to a lesser extent .
8940040	0	Cyclic_AMP	0,10	apolipoprotein_E	19,35	Cyclic AMP	apolipoprotein E	MESH:D000242	348	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|activity activity|amod|END_ENTITY	Cyclic_AMP induces apolipoprotein_E binding activity and promotes cholesterol efflux from a macrophage cell line to apolipoprotein acceptors .
12783871	0	Cyclic_AMP	0,10	aquaporin_5	21,32	Cyclic AMP	aquaporin 5	MESH:D000242	11830(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Cyclic_AMP regulates aquaporin_5 expression at both transcriptional and post-transcriptional levels through a protein kinase A pathway .
15050422	0	Cyclic_AMP	0,10	bradykinin	21,31	Cyclic AMP	bradykinin	MESH:D000242	3827	Chemical	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	Cyclic_AMP increases bradykinin receptor binding affinity in human endothelial cells .
8200990	0	Cyclic_AMP	0,10	bradykinin	32,42	Cyclic AMP	bradykinin	MESH:D000242	3827	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|synthesis synthesis|amod|END_ENTITY	Cyclic_AMP selectively enhances bradykinin receptor synthesis and expression in cultured arterial smooth muscle .
12810757	0	Cyclic_AMP	0,10	c-fos	85,90	Cyclic AMP	c-fos	MESH:D000242	2353	Chemical	Gene	mediates|amod|START_ENTITY reactive|nsubj|mediates reactive|xcomp|oxygen oxygen|dobj|expression expression|amod|END_ENTITY	Cyclic_AMP response element-binding protein mediates reactive oxygen species-induced c-fos expression .
8276117	0	Cyclic_AMP	0,10	c-myc	25,30	Cyclic AMP	c-myc	MESH:D000242	4609	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	Cyclic_AMP downregulates c-myc expression by inhibition of transcript initiation in human B-precursor Reh cells .
14744867	0	Cyclic_AMP	0,10	extracellular_signal-regulated_kinases_1_and_2	29,75	Cyclic AMP	extracellular signal-regulated kinases 1 and 2	MESH:D000242	5594	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Cyclic_AMP activation of the extracellular_signal-regulated_kinases_1_and_2 : implications for intestinal cell survival through the transient inhibition of apoptosis .
8905627	0	Cyclic_AMP	0,10	heparan_sulfate_proteoglycan	39,67	Cyclic AMP	heparan sulfate proteoglycan	MESH:D000242	25615(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Cyclic_AMP regulates basement membrane heparan_sulfate_proteoglycan , perlecan , metabolism in rat glomerular epithelial cells .
10415364	0	Cyclic_AMP	0,10	hydroxyindole-O-methyltransferase	21,54	Cyclic AMP	hydroxyindole-O-methyltransferase	MESH:D000242	396286(Tax:9031)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|amod|END_ENTITY	Cyclic_AMP increases hydroxyindole-O-methyltransferase mRNA levels in the chicken pineal gland , but is not required for circadian rhythmicity of this transcript .
8603101	0	Cyclic_AMP	0,10	insulin	97,104	Cyclic AMP	insulin	MESH:D000242	3630	Chemical	Gene	synthesis|amod|START_ENTITY additive|nsubj|synthesis additive|nmod|those those|nmod|END_ENTITY	Cyclic_AMP stimulates protein synthesis in L6 myoblasts and its effects are additive to those of insulin , vasopressin and 12-0-tetradecanoylphorbol-13-acetate .
10385254	0	Cyclic_AMP	0,10	interleukin-5	22,35	Cyclic AMP	interleukin-5	MESH:D000242	3567	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|synthesis synthesis|amod|END_ENTITY	Cyclic_AMP suppresses interleukin-5 synthesis by human helper T cells via the downregulation of the calcium mobilization pathway .
2847154	0	Cyclic_AMP	0,10	interleukin_1	50,63	Cyclic AMP	interleukin 1	MESH:D000242	111343(Tax:10090)	Chemical	Gene	START_ENTITY|dep|messenger messenger|nmod|END_ENTITY	Cyclic_AMP -- an intracellular second messenger for interleukin_1 .
20357815	0	Cyclic_AMP	0,10	matrix_metalloproteinase-1	22,48	Cyclic AMP	matrix metalloproteinase-1	MESH:D000242	4312	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Cyclic_AMP suppresses matrix_metalloproteinase-1 expression through inhibition of MAPK and GSK-3beta .
6306142	0	Cyclic_AMP	0,10	myosin	25,31	Cyclic AMP	myosin	MESH:D000242	79784	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Cyclic_AMP regulation of myosin isozymes in mammalian cardiac muscle .
11067915	0	Cyclic_AMP	0,10	p38	21,24	Cyclic AMP	p38	MESH:D000242	26416(Tax:10090)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|kinase kinase|amod|END_ENTITY	Cyclic_AMP activates p38 mitogen-activated protein kinase in Th2 cells : phosphorylation of GATA-3 and stimulation of Th2 cytokine gene expression .
16449637	0	Cyclic_AMP	0,10	p38	20,23	Cyclic AMP	p38	MESH:D000242	1432	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	Cyclic_AMP inhibits p38 activation via CREB-induced dynein light chain .
199422	0	Cyclic_AMP	0,10	parathyroid_hormone	80,99	Cyclic AMP	parathyroid hormone	MESH:D000242	24694(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY production|dep|prostaglandins prostaglandins|nmod|END_ENTITY	Cyclic_AMP production in rat calvaria in vitro : interaction prostaglandins with parathyroid_hormone .
2435393	0	Cyclic_AMP	0,10	parathyroid_hormone	38,57	Cyclic AMP	parathyroid hormone	MESH:D000242	24694(Tax:10116)	Chemical	Gene	START_ENTITY|dep|action action|nmod|END_ENTITY	Cyclic_AMP and the vascular action of parathyroid_hormone .
6323091	0	Cyclic_AMP	0,10	parathyroid_hormone	24,43	Cyclic AMP	parathyroid hormone	MESH:D000242	5741	Chemical	Gene	responses|amod|START_ENTITY responses|nmod|END_ENTITY	Cyclic_AMP responses to parathyroid_hormone and glucagon during lithium treatment .
7508894	0	Cyclic_AMP	0,10	parathyroid_hormone-related_protein	36,71	Cyclic AMP	parathyroid hormone-related protein	MESH:D000242	5744	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|release release|nmod|END_ENTITY	Cyclic_AMP increases the release of parathyroid_hormone-related_protein from a lung-cancer cell line .
8223983	0	Cyclic_AMP	0,10	parathyroid_hormone-related_protein	75,110	Cyclic AMP	parathyroid hormone-related protein	MESH:D000242	24695(Tax:10116)	Chemical	Gene	formation|amod|START_ENTITY stimulated|nsubjpass|formation stimulated|nmod|1-34 1-34|amod|END_ENTITY	Cyclic_AMP formation in rat bone and kidney cells is stimulated equally by parathyroid_hormone-related_protein -LRB- PTHrP -RRB- 1-34 and PTH 1-34 .
6086627	0	Cyclic_AMP	0,10	pro-vasoactive_intestinal_polypeptide	25,62	Cyclic AMP	pro-vasoactive intestinal polypeptide	MESH:D000242	7432	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Cyclic_AMP regulation of pro-vasoactive_intestinal_polypeptide / PHM-27 synthesis in human neuroblastoma cells .
2573431	0	Cyclic_AMP	0,10	somatostatin	22,34	Cyclic AMP	somatostatin	MESH:D000242	24797(Tax:10116)	Chemical	Gene	stimulates|amod|START_ENTITY END_ENTITY|nsubj|stimulates	Cyclic_AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133 .
2989368	0	Cyclic_AMP	0,10	terminal_deoxynucleotidyl_transferase	19,56	Cyclic AMP	terminal deoxynucleotidyl transferase	MESH:D000242	1791	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Cyclic_AMP induces terminal_deoxynucleotidyl_transferase in immature B_cell_leukemia lines .
1700492	0	Cyclic_AMP	0,10	thrombomodulin	21,35	Cyclic AMP	thrombomodulin	MESH:D000242	7056	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Cyclic_AMP increases thrombomodulin expression on membrane surface of cultured human umbilical vein endothelial cells .
1711842	0	Cyclic_AMP	0,10	transferrin	26,37	Cyclic AMP	transferrin	MESH:D000242	7018	Chemical	Gene	stimulation|amod|START_ENTITY stimulation|nmod|secretion secretion|compound|END_ENTITY	Cyclic_AMP stimulation of transferrin secretion by breast_cancer cell grown on extracellular matrix or in two-compartment culture chambers .
12606779	0	Cyclic_AMP	0,10	tumor_necrosis_factor_alpha	25,52	Cyclic AMP	tumor necrosis factor alpha	MESH:D000242	7124	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|production production|compound|END_ENTITY	Cyclic_AMP inhibition of tumor_necrosis_factor_alpha production induced by amyloidogenic C-terminal peptide of Alzheimer 's amyloid precursor protein in macrophages : involvement of multiple intracellular pathways and cyclic_AMP response element binding protein .
26720467	0	Cyclic_Adenosine_Monophosphate	0,30	Apolipoprotein_A1	49,66	Cyclic Adenosine Monophosphate	Apolipoprotein A1	null	335	Chemical	Gene	START_ENTITY|dobj|Expression Expression|compound|END_ENTITY	Cyclic_Adenosine_Monophosphate Activates Retinal Apolipoprotein_A1 Expression and Inhibits Myopic Eye Growth .
2873213	0	Cyclic_GMP	0,10	atrial_natriuretic_factor	48,73	Cyclic GMP	atrial natriuretic factor	MESH:D006152	24602(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|marker marker|nmod|END_ENTITY	Cyclic_GMP as mediator and biological marker of atrial_natriuretic_factor .
7575564	0	Cyclic_GMP	0,10	growth_hormone	22,36	Cyclic GMP	growth hormone	MESH:D006152	81668(Tax:10116)	Chemical	Gene	stimulates|amod|START_ENTITY END_ENTITY|nsubj|stimulates	Cyclic_GMP stimulates growth_hormone release in rat anterior pituitary cells .
2555724	0	Cyclic_GMP	0,10	vasopressin	26,37	Cyclic GMP	vasopressin	MESH:D006152	396995(Tax:9823)	Chemical	Gene	stimulation|amod|START_ENTITY stimulation|nmod|END_ENTITY	Cyclic_GMP stimulation by vasopressin in LLC-PK1 kidney epithelial cells is L-arginine-dependent .
8728355	0	Cyclic_adenosine_monophosphate	0,30	IL-4	63,67	Cyclic adenosine monophosphate	IL-4	null	3565	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Cyclic_adenosine_monophosphate -LRB- cAMP -RRB- differentially regulates IL-4 in thymocyte subsets .
1648785	0	Cyclic_adenosine_monophosphate	0,30	interleukin-1_beta	95,113	Cyclic adenosine monophosphate	interleukin-1 beta	null	3553	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|secretion secretion|nmod|END_ENTITY	Cyclic_adenosine_monophosphate decreases the secretion , but not the cell-associated levels , of interleukin-1_beta in lipopolysaccharide-activated human monocytes .
15149737	0	Cyclic_adenosine_monophosphate	0,30	natriuretic_peptide_receptor_C	48,78	Cyclic adenosine monophosphate	natriuretic peptide receptor C	null	4883	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Cyclic_adenosine_monophosphate -LRB- cAMP -RRB- increases natriuretic_peptide_receptor_C -LRB- NPR-C -RRB- expression in human aortic smooth muscle cells .
6857602	0	Cyclic_amides	0,13	thrombin	103,111	Cyclic amides	thrombin	CHEBI:23443	2147	Chemical	Gene	START_ENTITY|dep|inhibitors inhibitors|nmod|END_ENTITY	Cyclic_amides of N_alpha-arylsulfonylaminoacylated_4-amidinophenylalanine -- tight binding inhibitors of thrombin .
423205	0	Cyclic_amidine	0,14	indolamine_N-methyltransferase	29,59	Cyclic amidine	indolamine N-methyltransferase	null	100008695(Tax:9986)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Cyclic_amidine inhibitors of indolamine_N-methyltransferase .
11459670	0	Cyclic_imides	0,13	alpha-1A_adrenergic_receptor	38,66	Cyclic imides	alpha-1A adrenergic receptor	null	146	Chemical	Gene	START_ENTITY|nmod|antagonists antagonists|amod|END_ENTITY	Cyclic_imides as potent and selective alpha-1A_adrenergic_receptor antagonists .
2465812	0	Cyclic_nucleotides	0,18	parathyroid_hormone	87,106	Cyclic nucleotides	parathyroid hormone	MESH:D009712	280903(Tax:9913)	Chemical	Gene	uptake|nsubj|START_ENTITY uptake|nmod|END_ENTITY	Cyclic_nucleotides and the rapid inhibitions of bone 45Ca uptake in response to bovine parathyroid_hormone and 16,16-dimethyl _ prostaglandin_E2 in chicks .
2506761	0	Cyclic_nucleotides	0,18	prolactin	37,46	Cyclic nucleotides	prolactin	MESH:D009712	19109(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|stimulation stimulation|compound|END_ENTITY	Cyclic_nucleotides and polyamines in prolactin stimulation of lactose biosynthesis .
26007326	0	Cyclic_phosphatidic_acid	0,24	peroxisome_proliferator-activated_receptor_gamma	148,196	Cyclic phosphatidic acid	peroxisome proliferator-activated receptor gamma	null	5468	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Cyclic_phosphatidic_acid inhibits the secretion of vascular_endothelial_growth_factor from diabetic human coronary artery endothelial cells through peroxisome_proliferator-activated_receptor_gamma .
26007326	0	Cyclic_phosphatidic_acid	0,24	vascular_endothelial_growth_factor	51,85	Cyclic phosphatidic acid	vascular endothelial growth factor	null	7422	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|nmod|END_ENTITY	Cyclic_phosphatidic_acid inhibits the secretion of vascular_endothelial_growth_factor from diabetic human coronary artery endothelial cells through peroxisome_proliferator-activated_receptor_gamma .
12139017	0	Cyclipostins	0,12	hormone-sensitive_lipase	20,44	Cyclipostins	hormone-sensitive lipase	null	3991	Chemical	Gene	START_ENTITY|appos|inhibitors inhibitors|amod|END_ENTITY	Cyclipostins , novel hormone-sensitive_lipase inhibitors from Streptomyces sp .
16806857	0	Cyclodextrins	0,13	insulin	115,122	Cyclodextrins	insulin	MESH:D003505	3630	Chemical	Gene	START_ENTITY|dep|development development|nmod|powders powders|nmod|release release|nmod|END_ENTITY	Cyclodextrins in the production of large porous particles : development of dry powders for the sustained release of insulin to the lungs .
11929792	6	Cycloheximide	886,899	HGF	930,933	Cycloheximide	HGF	MESH:D003513	3082	Chemical	Gene	affect|nsubj|START_ENTITY affect|dobj|release release|nmod|END_ENTITY	Cycloheximide did not affect the release of HGF .
23357584	0	Cyclopamine	0,11	COX-2	31,36	Cyclopamine	COX-2	MESH:C000541	5743	Chemical	Gene	overexpression|amod|START_ENTITY overexpression|compound|END_ENTITY	Cyclopamine and jervine induce COX-2 overexpression in human erythroleukemia cells but only cyclopamine has a pro-apoptotic effect .
25368233	0	Cyclopamine	0,11	Sonic_Hedgehog	40,54	Cyclopamine	Sonic Hedgehog	MESH:C000541	6469	Chemical	Gene	decreased|nsubj|START_ENTITY decreased|dobj|expression expression|nmod|END_ENTITY	Cyclopamine decreased the expression of Sonic_Hedgehog and its downstream genes in colon_cancer stem cells .
10926779	0	Cyclopamine	0,11	Sonic_hedgehog	26,40	Cyclopamine	Sonic hedgehog	MESH:C000541	6469	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|transduction transduction|compound|END_ENTITY	Cyclopamine inhibition of Sonic_hedgehog signal transduction is not mediated through effects on cholesterol transport .
22798670	0	Cyclophilin_B	0,13	B_cell_lymphoma-3	119,136	Cyclophilin B	B cell lymphoma-3	null	602	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|nmod|induction induction|nmod|END_ENTITY	Cyclophilin_B attenuates the expression of TNF-a in lipopolysaccharide-stimulated macrophages through the induction of B_cell_lymphoma-3 .
22798670	0	Cyclophilin_B	0,13	TNF-a	43,48	Cyclophilin B	TNF-a	null	7124	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|nmod|END_ENTITY	Cyclophilin_B attenuates the expression of TNF-a in lipopolysaccharide-stimulated macrophages through the induction of B_cell_lymphoma-3 .
26544874	0	Cyclophosphamide	61,77	CYP2B6	42,48	Cyclophosphamide	CYP2B6	MESH:D003520	1555	Chemical	Gene	Bioactivation|compound|START_ENTITY Activity|nmod|Bioactivation Activity|compound|END_ENTITY	Cytochrome P450 Oxidoreductase Influences CYP2B6 Activity in Cyclophosphamide Bioactivation .
7534745	0	Cyclophosphamide	0,16	G-CSF	41,46	Cyclophosphamide	G-CSF	MESH:D003520	1440	Chemical	Gene	therapy|amod|START_ENTITY therapy|nmod|END_ENTITY	Cyclophosphamide -LRB- 3.6 g/m2 -RRB- therapy with G-CSF support for resistant myeloma .
25556071	0	Cyclophosphamide	10,26	MMP-9	44,49	Cyclophosphamide	MMP-9	MESH:D003520	81687(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of Cyclophosphamide on Expression of MMP-9 and TGF-b1 in Renal Tissue of Rats with Diabetes_Mellitus .
24036158	6	Cyclophosphamide	1137,1153	OAT1	1165,1169	Cyclophosphamide	MRP2	MESH:D003520	1244	Chemical	Gene	stimulated|compound|START_ENTITY END_ENTITY|nsubj|stimulated	Cyclophosphamide stimulated OAT1 , but did not affect OAT3 .
25778658	0	Cyclophosphamide	140,156	VEGF-A	50,56	Cyclophosphamide	VEGF-A	MESH:D003520	83785(Tax:10116)	Chemical	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of Vascular_Endothelial_Growth_Factor -LRB- VEGF-A -RRB- in Rat Mandibular Salivary Gland during Paraneoplastic Process and Treatment with Cyclophosphamide and Melatonin .
25778658	0	Cyclophosphamide	140,156	Vascular_Endothelial_Growth_Factor	14,48	Cyclophosphamide	Vascular Endothelial Growth Factor	MESH:D003520	83785(Tax:10116)	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of Vascular_Endothelial_Growth_Factor -LRB- VEGF-A -RRB- in Rat Mandibular Salivary Gland during Paraneoplastic Process and Treatment with Cyclophosphamide and Melatonin .
3196160	0	Cyclophosphamide	0,16	acetylcholinesterase	49,69	Cyclophosphamide	acetylcholinesterase	MESH:D003520	11423(Tax:10090)	Chemical	Gene	effects|amod|START_ENTITY END_ENTITY|nsubj|effects	Cyclophosphamide effects on fetal mouse cephalic acetylcholinesterase .
19637093	0	Cyclophosphamide	0,16	dectin-1	25,33	Cyclophosphamide	dectin-1	MESH:D003520	56644(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|amod|END_ENTITY	Cyclophosphamide reduces dectin-1 expression in the lungs of naive and Aspergillus_fumigatus-infected mice .
16797508	0	Cyclophosphamide	0,16	thioredoxin_reductase	28,49	Cyclophosphamide	thioredoxin reductase	MESH:D003520	25824	Chemical	Gene	suppresses|amod|START_ENTITY END_ENTITY|nsubj|suppresses	Cyclophosphamide suppresses thioredoxin_reductase in bladder tissue and its adaptive response via inductions of thioredoxin_reductase and glutathione peroxidase .
9521749	0	Cyclopiazonic_acid	0,18	ATPase	96,102	Cyclopiazonic acid	ATPase	MESH:C000543	1769	Chemical	Gene	effect|amod|START_ENTITY effect|dep|states states|nmod|END_ENTITY	Cyclopiazonic_acid effect on Ca2 + - dependent conformational states of the sarcoplasmic reticulum ATPase .
15350552	0	Cycloprodigiosin	0,16	inducible_nitric_oxide_synthase	30,61	Cycloprodigiosin	inducible nitric oxide synthase	MESH:C108328	24599(Tax:10116)	Chemical	Gene	up-regulates|compound|START_ENTITY END_ENTITY|nsubj|up-regulates	Cycloprodigiosin up-regulates inducible_nitric_oxide_synthase gene expression in hepatocytes stimulated by interleukin-1beta .
26133542	0	Cyclopropane	0,12	serine_racemase	44,59	Cyclopropane	serine racemase	MESH:C030797	63826	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|inhibitors inhibitors|compound|END_ENTITY	Cyclopropane derivatives as potential human serine_racemase inhibitors : unveiling novel insights into a difficult target .
2201500	0	Cyclosporin	0,11	IDDM	47,51	Cyclosporin	IDDM	MESH:D016572	3630	Chemical	Gene	therapy|compound|START_ENTITY therapy|nmod|END_ENTITY	Cyclosporin therapy for prevention and cure of IDDM .
22471287	0	Cyclosporin	0,11	chemokine_receptor	40,58	Cyclosporin	chemokine receptor	MESH:D016572	7852	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Cyclosporin but not everolimus inhibits chemokine_receptor expression on CD4 + T cell subsets circulating in the peripheral blood of renal transplant recipients .
7909900	0	Cyclosporin	0,11	erythropoietin	16,30	Cyclosporin	erythropoietin	MESH:D016572	2056	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	Cyclosporin for erythropoietin resistance .
9155951	0	Cyclosporin	0,11	intercellular_adhesion_molecule-1	21,54	Cyclosporin	intercellular adhesion molecule-1	MESH:D016572	15894(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Cyclosporin inhibits intercellular_adhesion_molecule-1 expression and reduces mast cell numbers in the asebia_mouse_model_of_chronic_skin_inflammation .
17760822	0	Cyclosporin-A	0,13	cyclooxygenase-2	41,57	Cyclosporin-A	cyclooxygenase-2	MESH:D016572	29527(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Cyclosporin-A inhibits the expression of cyclooxygenase-2 in gingiva .
18322274	0	Cyclosporin_A	0,13	AP1	124,127	Cyclosporin A	AP1	MESH:D016572	3726	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Cyclosporin_A promotes growth and invasiveness in vitro of human first-trimester trophoblast cells via MAPK3/MAPK1-mediated AP1 and Ca2 + / calcineurin/NFAT signaling pathways .
8814265	0	Cyclosporin_A	0,13	CD4	119,122	Cyclosporin A	CD4	MESH:D016572	920	Chemical	Gene	sensitivity|compound|START_ENTITY identifies|nsubj|sensitivity identifies|dobj|pathways pathways|acl|activated activated|nmod|triggering triggering|compound|END_ENTITY	Cyclosporin_A sensitivity of the HIV-1 long terminal repeat identifies distinct p56lck-dependent pathways activated by CD4 triggering .
17117422	0	Cyclosporin_A	38,51	P-glycoprotein	12,26	Cyclosporin A	P-glycoprotein	MESH:D016572	287115(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Effect of a P-glycoprotein inhibitor , Cyclosporin_A , on the disposition in rodent brain and blood of the 5-HT1A receptor radioligand , -LSB- 11C -RSB- -LRB- R -RRB- - -LRB- - -RRB- - RWAY .
8928836	0	Cyclosporin_A	0,13	P-glycoprotein	50,64	Cyclosporin A	P-glycoprotein	MESH:D016572	287115(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY induces|nsubj|treatment induces|dobj|overexpression overexpression|nmod|END_ENTITY	Cyclosporin_A treatment induces overexpression of P-glycoprotein in the kidney and other tissues .
9651111	0	Cyclosporin_A	0,13	P-glycoprotein	92,106	Cyclosporin A	P-glycoprotein	MESH:D016572	5243	Chemical	Gene	has|nsubj|START_ENTITY has|dobj|potency potency|nmod|inhibitor inhibitor|nmod|cells cells|acl|expressing expressing|dobj|levels levels|nmod|END_ENTITY	Cyclosporin_A has low potency as a calcineurin inhibitor in cells expressing high levels of P-glycoprotein .
16040734	0	Cyclosporin_A	0,13	PLCbeta1	43,51	Cyclosporin A	PLCbeta1	MESH:D016572	23236	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|END_ENTITY	Cyclosporin_A specifically affects nuclear PLCbeta1 in immunodepressed heart transplant patients with gingival_overgrowth .
17032751	0	Cyclosporin_A	0,13	apolipoprotein_AI	23,40	Cyclosporin A	apolipoprotein AI	MESH:D016572	335	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Cyclosporin_A inhibits apolipoprotein_AI gene expression .
2113532	0	Cyclosporin_A	0,13	c-fos	43,48	Cyclosporin A	c-fos	MESH:D016572	2353	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Cyclosporin_A suppresses cisplatin-induced c-fos gene expression in ovarian_carcinoma cells .
10999939	0	Cyclosporin_A	0,13	cyclooxygenase-2	51,67	Cyclosporin A	cyclooxygenase-2	MESH:D016572	29527(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|transcription transcription|amod|END_ENTITY	Cyclosporin_A selectively inhibits mitogen-induced cyclooxygenase-2 gene transcription in vascular smooth muscle cells .
9743504	0	Cyclosporin_A	0,13	cytochrome_C	85,97	Cyclosporin A	cytochrome C	MESH:D016572	54205	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|preventing preventing|dobj|release release|nmod|END_ENTITY	Cyclosporin_A inhibits apoptosis of human endothelial cells by preventing release of cytochrome_C from mitochondria .
12214041	0	Cyclosporin_A	0,13	cytochrome_c	34,46	Cyclosporin A	cytochrome c	MESH:D016572	100341175(Tax:9986)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|amod|END_ENTITY	Cyclosporin_A inhibits Al-induced cytochrome_c release from mitochondria in aged rabbits .
15383526	0	Cyclosporin_A	0,13	endothelial_nitric-oxide_synthase	51,84	Cyclosporin A	endothelial nitric-oxide synthase	MESH:D016572	287024(Tax:9913)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	Cyclosporin_A inhibits flow-mediated activation of endothelial_nitric-oxide_synthase by altering cholesterol content in caveolae .
7674231	0	Cyclosporin_A	0,13	insulin-like_growth_factor_I	38,66	Cyclosporin A	insulin-like growth factor I	MESH:D016572	3479	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|compound|END_ENTITY	Cyclosporin_A increases somatomedin_C insulin-like_growth_factor_I levels in chronic rheumatic_diseases .
2832109	0	Cyclosporin_A	0,13	interleukin_2	92,105	Cyclosporin A	interleukin 2	MESH:D016572	3558	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|nmod|END_ENTITY	Cyclosporin_A and prednisolone do not inhibit the expression of high-affinity receptors for interleukin_2 .
8031258	0	Cyclosporin_A	1,14	interleukin_5	24,37	Cyclosporin A	interleukin 5	MESH:D016572	3567	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	-LSB- Cyclosporin_A inhibits interleukin_5 -LRB- IL-5 -RRB- production from human peripheral lymphocytes -RSB- .
7674231	0	Cyclosporin_A	0,13	somatomedin_C	24,37	Cyclosporin A	somatomedin C	MESH:D016572	3479	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|amod|END_ENTITY	Cyclosporin_A increases somatomedin_C insulin-like_growth_factor_I levels in chronic rheumatic_diseases .
17935163	0	Cyclosporin_A	0,13	tax	30,33	Cyclosporin A	tax	MESH:D016572	1491938(Tax:11908)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Cyclosporin_A inhibits HTLV-I tax expression and shows anti-tumor effects in combination with VP-16 .
8366291	0	Cyclosporin_A	0,13	tumor_necrosis_factor	76,97	Cyclosporin A	tumor necrosis factor	MESH:D016572	21926(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Cyclosporin_A inhibits nitric_oxide production by L929 cells in response to tumor_necrosis_factor and interferon-gamma .
18569092	0	Cyclosporin_a	0,13	B7-DC	27,32	Cyclosporin a	B7-DC	MESH:D016572	80380	Chemical	Gene	Up-regulates|compound|START_ENTITY END_ENTITY|nsubj|Up-regulates	Cyclosporin_a Up-regulates B7-DC expression on dendritic cells in an IL-4-dependent manner in vitro , which is associated with decreased allostimulatory capacity of dendritic cells .
24522145	0	Cyclosporine	63,75	CYP3A	35,40	Cyclosporine	CYP3A	MESH:D016572	1576	Chemical	Gene	Genotypes|nmod|START_ENTITY Genotypes|compound|END_ENTITY	Effect of CYP3A4 * 22 , CYP3A5 * 3 , and CYP3A Combined Genotypes on Cyclosporine , Everolimus , and Tacrolimus Pharmacokinetics in Renal Transplantation .
10491310	0	Cyclosporine	0,12	Fas_ligand	27,37	Cyclosporine	Fas ligand	MESH:D016572	356	Chemical	Gene	downregulates|amod|START_ENTITY END_ENTITY|nsubj|downregulates	Cyclosporine downregulates Fas_ligand expression on vascular endothelial cells : implication for accelerated vasculopathy by immunosuppressive therapy .
12176916	0	Cyclosporine	0,12	P-glycoprotein	27,41	Cyclosporine	P-glycoprotein	MESH:D016572	5243	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Cyclosporine inhibition of P-glycoprotein in chronic myeloid_leukemia blast phase .
12612437	0	Cyclosporine	0,12	P-glycoprotein	24,38	Cyclosporine	P-glycoprotein	MESH:D016572	287115(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|expression expression|amod|END_ENTITY	Cyclosporine a augments P-glycoprotein expression in the regenerating rat liver .
18604533	0	Cyclosporine	0,12	P-glycoprotein	16,30	Cyclosporine	P-glycoprotein	MESH:D016572	287115(Tax:10116)	Chemical	Gene	START_ENTITY|appos|modulator modulator|amod|END_ENTITY	Cyclosporine , a P-glycoprotein modulator , increases -LSB- 18F -RSB- MPPF uptake in rat brain and peripheral tissues : microPET and ex vivo studies .
1549853	0	Cyclosporine	0,12	P450IIIA	27,35	Cyclosporine	P450IIIA	MESH:D016572	25642(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|nmod|END_ENTITY	Cyclosporine metabolism by P450IIIA in rat enterocytes -- another determinant of oral bioavailability ?
11349731	0	Cyclosporine	0,12	connective_tissue_growth_factor	32,63	Cyclosporine	connective tissue growth factor	MESH:D016572	64032(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Cyclosporine induces myocardial connective_tissue_growth_factor in spontaneously hypertensive rats on high-sodium diet .
15194301	0	Cyclosporine	0,12	endothelin-1	23,35	Cyclosporine	endothelin-1	MESH:D016572	1906	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|amod|END_ENTITY	Cyclosporine increases endothelin-1 plasma levels in renal transplant recipients .
19839837	0	Cyclosporine	0,12	endothelin-1	21,33	Cyclosporine	endothelin-1	MESH:D016572	1906	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|synthesis synthesis|amod|END_ENTITY	Cyclosporine induces endothelin-1 mRNA synthesis and nitric_oxide production in human proximal tubular epithelial cell cultures .
2183445	0	Cyclosporine	0,12	insulin	27,34	Cyclosporine	insulin	MESH:D016572	3630	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|secretion secretion|compound|END_ENTITY	Cyclosporine inhibition of insulin secretion : effect of tolbutamide and extracellular calcium concentration .
11817607	0	Cyclosporine	0,12	interleukin-15	54,68	Cyclosporine	interleukin-15	MESH:D016572	3600	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Cyclosporine differentially regulates interleukin-10 , interleukin-15 , and tumor_necrosis_factor_a production by rheumatoid synoviocytes .
21168695	0	Cyclosporine	0,12	interleukin-4	45,58	Cyclosporine	interleukin-4	MESH:D016572	3565	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|effects effects|nmod|END_ENTITY	Cyclosporine inhibits profibrotic effects of interleukin-4 and transforming growth factor b on human intrahepatic fibroblasts cultured in vitro .
23953581	0	Cyclosporine	0,12	interleukin_2	36,49	Cyclosporine	interleukin 2	MESH:D016572	16183(Tax:10090)	Chemical	Gene	START_ENTITY|acl|combined combined|nmod|END_ENTITY	Cyclosporine combined with nonlytic interleukin_2 / Fc fusion protein improves immune response to hepatitis_B vaccination in a mouse skin transplantation model .
10342319	0	Cyclosporine	0,12	p21	60,63	Cyclosporine	p21	MESH:D016572	644914	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Cyclosporine induces the expression of the cyclin inhibitor p21 .
12115224	0	Cyclosporine	0,12	vascular_endothelial_growth_factor	27,61	Cyclosporine	vascular endothelial growth factor	MESH:D016572	7422	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|production production|compound|END_ENTITY	Cyclosporine inhibition of vascular_endothelial_growth_factor production in rheumatoid synovial fibroblasts .
22205779	0	Cyclosporine_A	0,14	CYP3A4	54,60	Cyclosporine A	CYP3A4	MESH:D016572	1576	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Cyclosporine_A - and tacrolimus-mediated inhibition of CYP3A4 and CYP3A5 in vitro .
17161467	0	Cyclosporine_A	0,14	IL-17	38,43	Cyclosporine A	IL-17	MESH:D016572	3605	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	Cyclosporine_A inhibits IL-15-induced IL-17 production in CD4 + T cells via down-regulation of PI3K/Akt and NF-kappaB .
2735909	0	Cyclosporine_A	0,14	TNF	24,27	Cyclosporine A	TNF	MESH:D016572	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	Cyclosporine_A inhibits TNF production without decreasing TNF mRNA levels .
12633900	0	Cyclosporine_A	0,14	acetylcholinesterase	24,44	Cyclosporine A	acetylcholinesterase	MESH:D016572	83817(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Cyclosporine_A inhibits acetylcholinesterase activity in selected parts of the rat brain .
17467222	0	Cyclosporine_A	0,14	acetylcholinesterase	24,44	Cyclosporine A	acetylcholinesterase	MESH:D016572	83817(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Cyclosporine_A inhibits acetylcholinesterase activity in rats experimentally demyelinated with ethidium_bromide .
12239231	0	Cyclosporine_A	0,14	cyclooxygenase-2	26,42	Cyclosporine A	cyclooxygenase-2	MESH:D016572	29527(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Cyclosporine_A suppresses cyclooxygenase-2 expression in the rat kidney .
16316327	0	Cyclosporine_A	0,14	inducible_nitric_oxide_synthase	30,61	Cyclosporine A	inducible nitric oxide synthase	MESH:D016572	24599(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Cyclosporine_A and NAC on the inducible_nitric_oxide_synthase expression and nitric_oxide synthesis in rat renal artery cultured cells .
8796279	0	Cyclosporine_A	0,14	kallikrein	25,35	Cyclosporine A	kallikrein	MESH:D016572	408211(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|compound|END_ENTITY	Cyclosporine_A decreases kallikrein and BK2 mRNA expression in the rat renal cortex .
21912224	0	Cyclosporine_A	0,14	nerve_growth_factor	23,42	Cyclosporine A	nerve growth factor	MESH:D016572	4803	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Cyclosporine_A induces nerve_growth_factor expression via activation of MAPK p38 and NFAT5 .
3292818	0	Cyclosporine_A	0,14	renin	24,29	Cyclosporine A	renin	MESH:D016572	24715(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|secretion secretion|compound|END_ENTITY	Cyclosporine_A enhances renin secretion and production in isolated juxtaglomerular cells .
17636278	0	Cyclosporine_A	0,14	titin	23,28	Cyclosporine A	titin	MESH:D016572	7273	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Cyclosporine_A induces titin expression via MAPK/ERK signalling and improves proliferative and invasive potential of human trophoblast cells .
25894999	0	Cyclotide_Psysol	58,74	Prolyl_Oligopeptidase	20,41	Cyclotide Psysol	Prolyl Oligopeptidase	null	5550	Chemical	Gene	Activity|nmod|START_ENTITY Activity|compound|END_ENTITY	Inhibition of Human Prolyl_Oligopeptidase Activity by the Cyclotide_Psysol 2 Isolated from Psychotria solitudinum .
20333308	0	Cyclotraxin-B	0,13	TrkB	53,57	Cyclotraxin-B	TrkB	MESH:C554840	18212(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Cyclotraxin-B , the first highly potent and selective TrkB inhibitor , has anxiolytic properties in mice .
22560237	0	Cyclotraxin-B	0,13	TrkB	21,25	Cyclotraxin-B	TrkB	MESH:C554840	18212(Tax:10090)	Chemical	Gene	prevent|advmod|START_ENTITY prevent|nsubj|antagonist antagonist|compound|END_ENTITY	Cyclotraxin-B , a new TrkB antagonist , and glial blockade by propentofylline , equally prevent and reverse cold allodynia induced by BDNF or partial infraorbital_nerve_constriction in mice .
21783638	0	Cypermethrin	0,12	Glial_Fibrillary_Acidic_Protein	20,51	Cypermethrin	Glial Fibrillary Acidic Protein	MESH:C017160	24387(Tax:10116)	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|levels levels|amod|END_ENTITY	Cypermethrin alters Glial_Fibrillary_Acidic_Protein levels in the rat brain .
12206409	0	Cypermethrin	0,12	glutathione_S-transferase	21,46	Cypermethrin	glutathione S-transferase	MESH:C017160	373156	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|activity activity|amod|END_ENTITY	Cypermethrin induces glutathione_S-transferase activity in the shore crab , Carcinus maenas .
220278	0	Cyproheptadine	0,14	ACTH	69,73	Cyproheptadine	ACTH	MESH:D003533	5443	Chemical	Gene	treatment|amod|START_ENTITY treatment|dep|restoration restoration|nmod|END_ENTITY	Cyproheptadine treatment of Nelson 's _ syndrome : restoration of plasma ACTH circadian periodicity and reversal of response to TRF .
2832287	0	Cyproheptadine	0,14	corticotropin_releasing_hormone	28,59	Cyproheptadine	corticotropin releasing hormone	MESH:D003533	1392	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Cyproheptadine inhibits the corticotropin_releasing_hormone -LRB- CRH -RRB- -- induced hormone release in normal subjects .
22279581	0	Cys	32,35	HOGG1	16,21	Cys	HOGG1	CHEBI:17561	4968	Chemical	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	Contribution of HOGG1 Ser Cys polymorphism to the development of prostate_cancer in smokers : meta-analysis of 2779 cases and 3484 controls .
10064736	0	Cys	32,35	LDL_receptor	52,64	Cys	LDL receptor	CHEBI:17561	396801(Tax:9823)	Chemical	Gene	mutation|compound|START_ENTITY mutation|nmod|END_ENTITY	Identification of a novel Arg -- > Cys mutation in the LDL_receptor that contributes to spontaneous hypercholesterolemia in pigs .
18034822	0	Cys	9,12	factor_VIII	33,44	Cys	factor VIII	CHEBI:17561	2157	Chemical	Gene	results|compound|START_ENTITY results|nmod|END_ENTITY	Tyr346 -- > Cys mutation results in factor_VIII : C assay discrepancy and a normal bleeding phenotype - is this mild haemophilia_A ?
11181569	0	Cys	13,16	fibroblast_growth_factor_receptor_3	29,64	Cys	fibroblast growth factor receptor 3	CHEBI:17561	14184(Tax:10090)	Chemical	Gene	mutation|compound|START_ENTITY mutation|nmod|END_ENTITY	A Ser -LRB- 365 -RRB- -- > Cys mutation of fibroblast_growth_factor_receptor_3 in mouse downregulates Ihh/PTHrP signals and causes severe achondroplasia .
12493760	0	Cys	14,17	fucosyltransferase_III	81,103	Cys	fucosyltransferase III	CHEBI:17561	2525	Chemical	Gene	Importance|nmod|START_ENTITY Importance|nmod|END_ENTITY	Importance of Cys , Gln , and Tyr from the transmembrane domain of human alpha 3/4 fucosyltransferase_III for its localization and sorting in the Golgi of baby hamster kidney cells .
11992556	0	Cys	14,17	hOGG1	0,5	Cys	hOGG1	CHEBI:17561	4968	Chemical	Gene	START_ENTITY|nsubj|Ser Ser|compound|END_ENTITY	hOGG1 Ser -LRB- 326 -RRB- Cys polymorphism and modification by environmental factors of stomach_cancer risk in Chinese .
9559741	0	Cys	89,92	kerato-epithelin	109,125	Cys	kerato-epithelin	CHEBI:17561	7045	Chemical	Gene	mutation|compound|START_ENTITY mutation|nmod|gene gene|amod|END_ENTITY	Lattice corneal_dystrophy_type_1 in a Canadian kindred is associated with the Arg124 _ -- > _ Cys mutation in the kerato-epithelin gene .
8486765	0	Cys	116,119	lipoprotein_lipase	136,154	Cys	lipoprotein lipase	CHEBI:17561	4023	Chemical	Gene	mutation|compound|START_ENTITY mutation|nmod|gene gene|amod|END_ENTITY	Gene-environment interaction in the conversion of a mild-to-severe phenotype in a patient homozygous for a Ser172 -- > Cys mutation in the lipoprotein_lipase gene .
1314592	0	Cysteamine	0,10	Y2_receptor	45,56	Cysteamine	Y2 receptor	MESH:D003543	281943(Tax:9913)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|amod|END_ENTITY	Cysteamine selectively enhances neuropeptide Y2_receptor binding activity .
3081777	0	Cysteamine	0,10	prolactin	114,123	Cysteamine	prolactin	MESH:D003543	280901(Tax:9913)	Chemical	Gene	modify|nsubj|START_ENTITY modify|parataxis|suggests suggests|nsubj|comparison comparison|nmod|effects effects|nmod|END_ENTITY	Cysteamine , zinc , and thiols modify detectability of rat pituitary prolactin : a comparison with effects on bovine prolactin suggests differences in hormone storage .
3081777	0	Cysteamine	0,10	prolactin	67,76	Cysteamine	prolactin	MESH:D003543	24683(Tax:10116)	Chemical	Gene	modify|nsubj|START_ENTITY modify|dobj|detectability detectability|nmod|END_ENTITY	Cysteamine , zinc , and thiols modify detectability of rat pituitary prolactin : a comparison with effects on bovine prolactin suggests differences in hormone storage .
6479101	0	Cysteamine	0,10	prolactin	20,29	Cysteamine	prolactin	MESH:D003543	24683(Tax:10116)	Chemical	Gene	depletes|nsubj|START_ENTITY depletes|dobj|END_ENTITY	Cysteamine depletes prolactin -LRB- PRL -RRB- but does not alter the structure of PRL-containing granules in the anterior pituitary .
6832077	0	Cysteamine	0,10	prolactin	20,29	Cysteamine	prolactin	MESH:D003543	24683(Tax:10116)	Chemical	Gene	depletes|nsubj|START_ENTITY depletes|dobj|END_ENTITY	Cysteamine depletes prolactin in young and old hyperprolactinemic rats .
7089575	0	Cysteamine	0,10	prolactin	56,65	Cysteamine	prolactin	MESH:D003543	5617	Chemical	Gene	START_ENTITY|dep|depletor depletor|nmod|END_ENTITY	Cysteamine : a potent and specific depletor of pituitary prolactin .
3079953	0	Cysteamine	0,10	thyrotropin-releasing_hormone	49,78	Cysteamine	thyrotropin-releasing hormone	MESH:D003543	7200	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|xcomp|END_ENTITY	Cysteamine decreases prolactin responsiveness to thyrotropin-releasing_hormone in normal men .
26745957	0	Cysteine	49,57	ASL	31,34	Cysteine	ASL	MESH:D003545	435	Chemical	Gene	Proteins|nmod|START_ENTITY Proteins|compound|END_ENTITY	Effect of Cysteamine on Mutant ASL Proteins with Cysteine for Arginine Substitutions .
26290606	0	Cysteine	9,17	Calcium-Sensing_Receptor	39,63	Cysteine	Calcium-Sensing Receptor	MESH:D003545	100520980	Chemical	Gene	Residues|compound|START_ENTITY Residues|nmod|END_ENTITY	Critical Cysteine Residues in Both the Calcium-Sensing_Receptor and the Allosteric Activator AMG_416 Underlie the Mechanism of Action .
26290606	0	Cysteine	9,17	Calcium-Sensing_Receptor	39,63	Cysteine	Calcium-Sensing Receptor	MESH:D003545	100520980	Chemical	Gene	Residues|compound|START_ENTITY Residues|nmod|END_ENTITY	Critical Cysteine Residues in Both the Calcium-Sensing_Receptor and the Allosteric Activator AMG_416 Underlie the Mechanism of Action .
22798952	0	Cysteine	23,31	Cathepsin_B	94,105	Cysteine	Cathepsin B	MESH:D003545	13030(Tax:10090)	Chemical	Gene	Cathepsins|compound|START_ENTITY Impact|nmod|Cathepsins Impact|dep|END_ENTITY	Differential Impact of Cysteine Cathepsins on Genetic Mouse Models of De novo Carcinogenesis : Cathepsin_B as Emerging Therapeutic Target .
26101100	0	Cysteine	0,8	IGF-I	66,71	Cysteine	IGF-I	MESH:D003545	16000(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Cysteine induces longitudinal bone growth in mice by upregulating IGF-I .
26654692	0	Cysteine	86,94	Neonatal_Fc_Receptor	0,20	Cysteine	Neonatal Fc Receptor	MESH:D003545	2217	Chemical	Gene	Tolerance|nmod|START_ENTITY Tolerance|compound|END_ENTITY	Neonatal_Fc_Receptor Binding Tolerance toward the Covalent Conjugation of Payloads to Cysteine 34 of Human Albumin Variants .
25452301	0	Cysteine	32,40	RCC1	54,58	Cysteine	RCC1	MESH:D003545	1104	Chemical	Gene	Oxidation|compound|START_ENTITY Oxidation|nmod|END_ENTITY	Disruption of the Ran System by Cysteine Oxidation of RCC1 .
11463334	0	Cysteine	0,8	SNAP-25	21,28	Cysteine	SNAP-25	MESH:D003545	25012(Tax:10116)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Cysteine residues of SNAP-25 are required for SNARE disassembly and exocytosis , but not for membrane targeting .
26593911	0	Cysteine	20,28	Selenium_Binding_Protein-1	63,89	Cysteine	Selenium Binding Protein-1	MESH:D003545	8991	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	A Critical Role for Cysteine 57 in the Biological Functions of Selenium_Binding_Protein-1 .
15805548	0	Cysteine	0,8	apolipoprotein_A-I	26,44	Cysteine	apolipoprotein A-I	MESH:D003545	335	Chemical	Gene	mutants|amod|START_ENTITY mutants|nmod|END_ENTITY	Cysteine mutants of human apolipoprotein_A-I : a study of secondary structural and functional properties .
9779840	0	Cysteine	0,8	cathepsin_K	20,31	Cysteine	cathepsin K	MESH:D003545	1513	Chemical	Gene	mRNA|amod|START_ENTITY mRNA|compound|END_ENTITY	Cysteine proteinase cathepsin_K mRNA is expressed in synovium of patients with rheumatoid_arthritis and is detected at sites of synovial bone_destruction .
11287364	0	Cysteine	0,8	cysteine_dioxygenase	33,53	Cysteine	cysteine dioxygenase	MESH:D003545	81718(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Cysteine regulates expression of cysteine_dioxygenase and gamma-glutamylcysteine_synthetase in cultured rat hepatocytes .
12949352	0	Cysteine	0,8	cysteine_dioxygenase	79,99	Cysteine	cysteine dioxygenase	MESH:D003545	81718(Tax:10116)	Chemical	Gene	signal|nsubj|START_ENTITY signal|amod|responsible responsible|nmod|regulation regulation|nmod|END_ENTITY	Cysteine is the metabolic signal responsible for dietary regulation of hepatic cysteine_dioxygenase and glutamate_cysteine ligase in intact rats .
21454633	0	Cysteine	0,8	huntingtin	44,54	Cysteine	huntingtin	MESH:D003545	15194(Tax:10090)	Chemical	Gene	oxidation|amod|START_ENTITY oxidation|nmod|END_ENTITY	Cysteine oxidation within N-terminal mutant huntingtin promotes oligomerization and delays clearance of soluble protein .
9076992	0	Cysteine	0,8	serine_acetyltransferase	62,86	Cysteine	serine acetyltransferase	MESH:D003545	842043(Tax:3702)	Chemical	Gene	synthesis|amod|START_ENTITY synthesis|dep|interactions interactions|nmod|END_ENTITY	Cysteine synthesis in plants : protein-protein interactions of serine_acetyltransferase from Arabidopsis_thaliana .
10866303	0	Cysteine	0,8	tumor_necrosis_factor-related_apoptosis-inducing_ligand	23,78	Cysteine	tumor necrosis factor-related apoptosis-inducing ligand	MESH:D003545	8743	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activity activity|amod|END_ENTITY	Cysteine 230 modulates tumor_necrosis_factor-related_apoptosis-inducing_ligand activity .
7578014	0	Cysteines	0,9	glucocorticoid_receptor	61,84	Cysteines	glucocorticoid receptor	null	2908	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Cysteines 638 and 665 in the hormone binding domain of human glucocorticoid_receptor define the specificity to glucocorticoids .
25594724	0	Cysteinyl	42,51	Flap	67,71	Cysteinyl	Flap	CHEBI:23511	241	Chemical	Gene	Residue|compound|START_ENTITY Residue|nmod|END_ENTITY	Inhibition of Urease by Modification of a Cysteinyl Residue in the Flap Covering the Active Site .
597100	0	Cytochalasin_B	20,34	TA3	38,41	Cytochalasin B	TA3	MESH:D003571	134860	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	In vitro effects of Cytochalasin_B on TA3 tumor cells .
8409756	0	Cytochalasin_D	0,14	tumor_necrosis_factor	51,72	Cytochalasin D	tumor necrosis factor	MESH:D015638	21926(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	Cytochalasin_D inhibits lipopolysaccharide-induced tumor_necrosis_factor production in macrophages .
10396288	0	Cytokeratin	0,11	E-12	20,24	Cytokeratin	E-12	null	64100	Chemical	Gene	START_ENTITY|dobj|immunoreactivity immunoreactivity|compound|END_ENTITY	Cytokeratin 34 beta E-12 immunoreactivity in benign prostatic acini .
24312098	0	Cytokines	102,111	IL-1	87,91	Cytokines	IL-1	MESH:D016207	3552	Chemical	Gene	Family|nmod|START_ENTITY Family|compound|END_ENTITY	The Interleukin-1a Precursor is Biologically Active and is Likely a Key Alarmin in the IL-1 Family of Cytokines .
16581899	0	Cytosine_arabinoside	0,20	caspase-3	75,84	Cytosine arabinoside	caspase-3	MESH:D003561	836	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|pathway pathway|amod|END_ENTITY	Cytosine_arabinoside induces programmed endothelial cell death through the caspase-3 pathway .
10559474	0	Cytostatin	0,10	phosphatase_2A	96,110	Cytostatin	phosphatase 2A	MESH:C088526	19052(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Cytostatin , an inhibitor of cell adhesion to extracellular matrix , selectively inhibits protein phosphatase_2A .
10728786	0	D,L-alpha-difluoromethylornithine	0,33	ornithine_decarboxylase	64,87	D,L-alpha-difluoromethylornithine	ornithine decarboxylase	null	18263(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	D,L-alpha-difluoromethylornithine , an irreversible inhibitor of ornithine_decarboxylase , induces differentiation in MEL cells .
18561912	0	D-161	0,5	monoamine_transporter	34,55	D-161	monoamine transporter	null	25549(Tax:10116)	Chemical	Gene	START_ENTITY|appos|blocker blocker|compound|END_ENTITY	D-161 , a novel pyran-based triple monoamine_transporter blocker : behavioral pharmacological evidence for antidepressant-like action .
26046462	0	D-2-hydroxyglutarate	19,39	IDH1	58,62	D-2-hydroxyglutarate	IDH1	null	3417	Chemical	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	The oncometabolite D-2-hydroxyglutarate induced by mutant IDH1 or -2 blocks osteoblast differentiation in vitro and in vivo .
9802959	0	D-22888	39,46	PDE4	23,27	D-22888	PDE4	MESH:C116972	5141	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Effects of a selective PDE4 inhibitor , D-22888 , on human airways and eosinophils in vitro and late phase allergic pulmonary eosinophilia in guinea_pigs .
6127039	0	D-2343	38,44	beta_2-adrenoceptor	8,27	D-2343	beta 2-adrenoceptor	MESH:C033651	154	Chemical	Gene	agonists|amod|START_ENTITY agonists|amod|END_ENTITY	Two new beta_2-adrenoceptor agonists , D-2343 and QH_25 , studied in asthmatic patients .
7735141	0	D-3-hydroxybutyrate	98,117	BDH	133,136	D-3-hydroxybutyrate	BDH	CHEBI:10983	117099(Tax:10116)	Chemical	Gene	dehydrogenase|compound|START_ENTITY dehydrogenase|appos|END_ENTITY	Effect of peroxisomes proliferators and hypolipemic agents on mitochondrial inner membrane linked D-3-hydroxybutyrate dehydrogenase -LRB- BDH -RRB- .
9195044	0	D-3-hydroxybutyrate	37,56	BDH	72,75	D-3-hydroxybutyrate	BDH	CHEBI:10983	117099(Tax:10116)	Chemical	Gene	dehydrogenase|compound|START_ENTITY site|nmod|dehydrogenase site|appos|END_ENTITY	Alkylation at the active site of the D-3-hydroxybutyrate dehydrogenase -LRB- BDH -RRB- , a membrane phospholipid-dependent enzyme , by 3-chloroacetyl_pyridine_adenine_dinucleotide -LRB- 3-CAPAD -RRB- .
202692	0	D-3-mercapto-2-methylpropanoyl-l-proline	11,51	angiotensin_I-converting_enzyme	89,120	D-3-mercapto-2-methylpropanoyl-l-proline	angiotensin I-converting enzyme	CHEBI:3380	1636	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	SQ 14,225 -LRB- D-3-mercapto-2-methylpropanoyl-l-proline -RRB- , a novel orally active inhibitor of angiotensin_I-converting_enzyme .
21425255	0	D-4F	0,4	apoA-I	9,15	D-4F	apoA-I	null	11806(Tax:10090)	Chemical	Gene	START_ENTITY|appos|peptide peptide|amod|END_ENTITY	D-4F , an apoA-I mimetic peptide , inhibits proliferation and tumorigenicity of epithelial_ovarian_cancer cells by upregulating the antioxidant enzyme MnSOD .
7003099	0	D-600	10,15	renin	42,47	D-600	renin	MESH:D005711	24715(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Effect of D-600 on inhibition of in vitro renin release in the rat by high extracellular potassium and angiotensin_II .
7304195	0	D-Ala2-met-enkephalinamide	10,36	choline_acetyltransferase	69,94	D-Ala2-met-enkephalinamide	choline acetyltransferase	null	290567(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|nmod|END_ENTITY	Effect of D-Ala2-met-enkephalinamide and morphine on the activity of choline_acetyltransferase and acetylcholinesterase in rat brain .
6618761	0	D-Ala5	0,6	elastin	21,28	D-Ala5	elastin	null	2006	Chemical	Gene	analog|amod|START_ENTITY analog|nmod|END_ENTITY	D-Ala5 analog of the elastin polypentapeptide .
20648222	0	D-Amino_Acid	29,41	DAAO	51,55	D-Amino Acid	DAAO	CHEBI:16733	1610	Chemical	Gene	Inhibitors|amod|START_ENTITY Inhibitors|appos|END_ENTITY	The Therapeutic Potential of D-Amino_Acid Oxidase -LRB- DAAO -RRB- Inhibitors .
12135762	0	D-Amino_acid	0,12	C-type_natriuretic_peptide	28,54	D-Amino acid	C-type natriuretic peptide	CHEBI:16733	4880	Chemical	Gene	residue|amod|START_ENTITY residue|nmod|END_ENTITY	D-Amino_acid residue in the C-type_natriuretic_peptide from the venom of the mammal , Ornithorhynchus_anatinus , the Australian platypus .
17303072	0	D-DOPA	20,26	D-amino_acid_oxidase	40,60	D-DOPA	D-amino acid oxidase	CHEBI:49169	1610	Chemical	Gene	oxidation|amod|START_ENTITY oxidation|nmod|END_ENTITY	Structural basis of D-DOPA oxidation by D-amino_acid_oxidase : alternative pathway for dopamine biosynthesis .
10218785	0	D-Fenfluramine	0,14	Fos	42,45	D-Fenfluramine	Fos	null	314322(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	D-Fenfluramine induces serotonin-mediated Fos expression in corticotropin-releasing_factor and oxytocin neurons of the hypothalamus , and serotonin-independent Fos expression in enkephalin and neurotensin neurons of the amygdala .
9061466	0	D-MePhe-Pro-Arg	199,214	thrombin	225,233	D-MePhe-Pro-Arg	thrombin	null	2147	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Narrow-bore liquid chromatography-tandem mass spectrometry with simultaneous radioactivity monitoring for partially characterizing the biliary metabolites of an arginine_fluoroalkyl_ketone analog of D-MePhe-Pro-Arg , a potent thrombin inhibitor .
22200571	0	D-PDMP	110,116	insulin_receptor	20,36	D-PDMP	insulin receptor	null	3643	Chemical	Gene	Dissociation|nmod|START_ENTITY Dissociation|nmod|END_ENTITY	Dissociation of the insulin_receptor from caveolae during TNFa-induced insulin resistance and its recovery by D-PDMP .
12781189	0	D-Phe-Pro-Arg	0,13	thrombin	19,27	D-Phe-Pro-Arg	thrombin	null	2147	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	D-Phe-Pro-Arg type thrombin inhibitors : unexpected selectivity by modification of the P1 moiety .
17655880	0	D-Psicose	0,9	MCP-1	37,42	D-Psicose	MCP-1	MESH:C003243	6347	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	D-Psicose inhibits the expression of MCP-1 induced by high-glucose stimulation in HUVECs .
26941605	0	D-Serine	0,8	PSD-95	49,55	D-Serine	PSD-95	CHEBI:16523	1742	Chemical	Gene	Associated|nsubj|START_ENTITY Associated|nmod|END_ENTITY	D-Serine and Serine_Racemase Are Associated with PSD-95 and Glutamatergic Synapse Stability .
7541770	0	D-Trp-6-GnRH	55,67	gonadotropin-releasing-hormone	15,45	D-Trp-6-GnRH	gonadotropin-releasing-hormone	CHEBI:63633	2796	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Effects of the gonadotropin-releasing-hormone agonist , D-Trp-6-GnRH , on prolactin secretion in healthy young men .
26865911	0	D-Xylose	0,8	phosphoenolpyruvate_carboxylase	77,108	D-Xylose	phosphoenolpyruvate carboxylase	MESH:D014994	362282(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	D-Xylose as a sugar complement regulates blood glucose levels by suppressing phosphoenolpyruvate_carboxylase -LRB- PEPCK -RRB- in streptozotocin-nicotinamide-induced diabetic rats and by enhancing glucose uptake in vitro .
18930000	0	D-allose	11,19	HuH-7	113,118	D-allose	HuH-7	CHEBI:40822	284424	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Rare sugar D-allose enhances anti-tumor effect of 5-fluorouracil on the human hepatocellular_carcinoma cell line HuH-7 .
2859127	0	D-alpha-tocopherol	59,77	ornithine_decarboxylase	81,104	D-alpha-tocopherol	ornithine decarboxylase	CHEBI:18145	18263(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|induction induction|amod|END_ENTITY	Inhibitory effects of glutathione level-raising agents and D-alpha-tocopherol on ornithine_decarboxylase induction and mouse skin_tumor promotion by 12-O-tetradecanoylphorbol-13-acetate .
19823762	0	D-amino_acid	10,22	CA4	71,74	D-amino acid	CA4	CHEBI:16733	762	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Increased D-amino_acid oxidase expression in the bilateral hippocampal CA4 of schizophrenic patients : a post-mortem study .
19591808	0	D-amino_acid	45,57	DAAO	67,71	D-amino acid	DAAO	CHEBI:16733	1610	Chemical	Gene	oxidase|amod|START_ENTITY oxidase|appos|END_ENTITY	Commentary : genome-based CNS drug discovery : D-amino_acid oxidase -LRB- DAAO -RRB- as a novel target for antipsychotic medications : progress and challenges .
18455394	0	D-amino_acid	65,77	DAO	87,90	D-amino acid	DAO	CHEBI:16733	1610	Chemical	Gene	oxidase|amod|START_ENTITY oxidase|appos|END_ENTITY	The discovery of fused pyrrole_carboxylic_acids as novel , potent D-amino_acid oxidase -LRB- DAO -RRB- inhibitors .
9401756	0	D-amino_acid	16,28	DAO	38,41	D-amino acid	DAO	CHEBI:16733	114027(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Distribution of D-amino_acid oxidase -LRB- DAO -RRB- activity in the medulla and thoracic spinal cord of the rat : implications for a role for D-serine in autonomic function .
13782	0	D-amino_acid	60,72	Dao	88,91	D-amino acid	Dao	CHEBI:16733	13142(Tax:10090)	Chemical	Gene	oxidase|amod|START_ENTITY locus|amod|oxidase locus|appos|END_ENTITY	Genetics of peroxisomal enzymes in the mouse : nonlinkage of D-amino_acid oxidase locus -LRB- Dao -RRB- to catalase -LRB- Cs -RRB- and L-alpha-hydroxyacid oxidase -LRB- Hao-1 -RRB- loci on chromosome 2 .
400927	0	D-amino_acid	141,153	beta-endorphin	187,201	D-amino acid	beta-endorphin	CHEBI:16733	5443	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Metabolism of potent enkephalin analogs -LRB- FK_33-824 , D-Ala2 , _ pentafluorophenylalanine-4-enkephalinamide and a dimer of D-Ala2-enkephalin -RRB- and D-amino_acid substituted derivatives of human beta-endorphin .
16470869	0	D-amphetamine	91,104	AChE	26,30	D-amphetamine	AChE	MESH:D003913	114549(Tax:7955)	Chemical	Gene	identification|nmod|START_ENTITY identification|nmod|END_ENTITY	Genetic identification of AChE as a positive modulator of addiction to the psychostimulant D-amphetamine in zebrafish .
14574438	0	D-amphetamine	0,13	catechol-O-methyltransferase	27,55	D-amphetamine	catechol-O-methyltransferase	MESH:D003913	12846(Tax:10090)	Chemical	Gene	responses|amod|START_ENTITY responses|nmod|END_ENTITY	D-amphetamine responses in catechol-O-methyltransferase -LRB- COMT -RRB- disrupted mice .
8788863	0	D-amphetamine	11,24	neurotensin	91,102	D-amphetamine	neurotensin	MESH:D003913	299757(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of D-amphetamine and phencyclidine on behavior and extracellular concentrations of neurotensin and dopamine in the ventral striatum and the medial prefrontal cortex of the rat .
20031274	0	D-aspartate	23,34	D-aspartate_oxidase	38,57	D-aspartate	D-aspartate oxidase	CHEBI:29994	70503(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Persistent increase of D-aspartate in D-aspartate_oxidase mutant mice induces a precocious hippocampal age-dependent synaptic plasticity and spatial memory decay .
20564559	0	D-aspartyl	42,52	elastin	69,76	D-aspartyl	elastin	CHEBI:48094	2006	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Oxidative stress induces the formation of D-aspartyl residues in the elastin mimic peptides .
2570694	0	D-beta-aminoglutaryl-L-alanine	46,76	gamma-Glutamylcyclotransferase	0,30	D-beta-aminoglutaryl-L-alanine	gamma-Glutamylcyclotransferase	null	79017	Chemical	Gene	inhibition|nmod|START_ENTITY END_ENTITY|dep|inhibition	gamma-Glutamylcyclotransferase : inhibition by D-beta-aminoglutaryl-L-alanine and analysis of the solvent kinetic isotope effect .
22711011	0	D-chiro-inositol	0,16	NFATc1	101,107	D-chiro-inositol	NFATc1	null	4772	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	D-chiro-inositol negatively regulates the formation of multinucleated osteoclasts by down-regulating NFATc1 .
9542792	0	D-fenfluramine	22,36	Prolactin	0,9	D-fenfluramine	Prolactin	null	5617	Chemical	Gene	challenge|amod|START_ENTITY response|nmod|challenge response|compound|END_ENTITY	Prolactin response to D-fenfluramine challenge test as a predictor of treatment response to haloperidol in acute schizophrenia .
9704866	0	D-fenfluramine	22,36	Prolactin	0,9	D-fenfluramine	Prolactin	null	5617	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Prolactin response to D-fenfluramine in outpatients with major_depression .
8052154	0	D-fenfluramine	48,62	growth_hormone	76,90	D-fenfluramine	growth hormone	null	2688	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|END_ENTITY	The effect of hypocaloric diet with and without D-fenfluramine treatment on growth_hormone release after growth_hormone-releasing factor stimulation in patients with android_obesity .
10101728	0	D-fenfluramine	51,65	prolactin	29,38	D-fenfluramine	prolactin	null	5617	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Seasonal variation in plasma prolactin response to D-fenfluramine in healthy subjects .
12943959	0	D-fenfluramine	30,44	prolactin	8,17	D-fenfluramine	prolactin	null	5617	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Blunted prolactin response to D-fenfluramine in post-stroke major_depression .
8373918	0	D-fenfluramine	47,61	prolactin	25,34	D-fenfluramine	prolactin	null	5617	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Effect of lithium on the prolactin response to D-fenfluramine in healthy subjects .
9723152	0	D-fenfluramine	29,43	prolactin	7,16	D-fenfluramine	prolactin	null	5617	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Plasma prolactin response to D-fenfluramine is blunted in bulimic patients with frequent binge episodes .
7805769	0	D-fenfluramine	8,22	serotonin_transporter	33,54	D-fenfluramine	serotonin transporter	null	6532	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|compound|END_ENTITY	Chronic D-fenfluramine decreases serotonin_transporter messenger RNA expression in dorsal raphe nucleus .
11454339	1	D-fructose	92,102	GLUT5	116,121	D-fructose	GLUT5	CHEBI:48095	6518	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Access to 5-thio-D-fructose and interaction with the D-fructose transporter , GLUT5 .
14687582	0	D-fructose	45,55	tumor_necrosis_factor-alpha	14,41	D-fructose	tumor necrosis factor-alpha	CHEBI:48095	100009088(Tax:9986)	Chemical	Gene	transport|amod|START_ENTITY effect|nmod|transport effect|nmod|END_ENTITY	The effect of tumor_necrosis_factor-alpha on D-fructose intestinal transport in rabbits .
602771	0	D-galactosamine	14,29	LCAT	33,37	D-galactosamine	LCAT	CHEBI:60313	24530(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|amod|END_ENTITY	The effect of D-galactosamine on LCAT secretion and ultrastructure of isolated rat hepatocytes .
18004231	0	D-galactosamine	109,124	iNOS	91,95	D-galactosamine	iNOS	CHEBI:60313	24599(Tax:10116)	Chemical	Gene	rats|amod|START_ENTITY END_ENTITY|nmod|rats	Insulin-like_growth_factor_1 prevents liver_injury through the inhibition of TNF-alpha and iNOS induction in D-galactosamine and LPS-treated rats .
22514887	0	D-galactosamine	46,61	p53	14,17	D-galactosamine	p53	CHEBI:60313	301300(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Expression Expression|nmod|END_ENTITY	Expression of p53 during apoptosis induced by D-galactosamine and the protective role of PGE1 in cultured rat hepatocytes .
23980368	0	D-galactose	116,127	Toll_receptors	59,73	D-galactose	Toll receptors	MESH:D005690	29260(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of total paeony glucosides on mRNA expressions of Toll_receptors and interleukin-33 in the brain tissue of D-galactose induced aging rats : an experimental research -RSB- .
9886976	0	D-galactose	75,86	insulin-like_growth_factor_I	10,38	D-galactose	insulin-like growth factor I	MESH:D005690	24482(Tax:10116)	Chemical	Gene	absorption|nmod|START_ENTITY END_ENTITY|nmod|absorption	Effect of insulin-like_growth_factor_I on in vivo intestinal absorption of D-galactose in cirrhotic rats .
16707226	0	D-galactose	11,22	peripheral-type_benzodiazepine_receptor	56,95	D-galactose	peripheral-type benzodiazepine receptor	MESH:D005690	24230(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of D-galactose on the expression of hippocampal peripheral-type_benzodiazepine_receptor and spatial memory performances in rats .
2881656	0	D-galactose	26,37	somatostatin	10,22	D-galactose	somatostatin	MESH:D005690	24797(Tax:10116)	Chemical	Gene	transport|amod|START_ENTITY Effect|nmod|transport Effect|nmod|END_ENTITY	Effect of somatostatin on D-galactose transport across the small intestine of rats .
6114077	0	D-glucaric_acid	37,52	gamma-glutamyl_transpeptidase	6,35	D-glucaric acid	gamma-glutamyl transpeptidase	MESH:D005937	92086	Chemical	Gene	excretion|amod|START_ENTITY excretion|amod|END_ENTITY	Serum gamma-glutamyl_transpeptidase , D-glucaric_acid excretion and plasma half-life of antipyrine in newborns with severe jaundice of unknown etiology and due to glucose-6-phosphate_dehydrogenase deficiency in Greece .
19254699	0	D-glucosamine	0,13	HIF-1alpha	29,39	D-glucosamine	HIF-1alpha	CHEBI:28393	3091	Chemical	Gene	down-regulates|amod|START_ENTITY END_ENTITY|nsubj|down-regulates	D-glucosamine down-regulates HIF-1alpha through inhibition of protein translation in DU145 prostate_cancer cells .
17892867	0	D-glucosamine	104,117	interleukin-2	67,80	D-glucosamine	interleukin-2	CHEBI:28393	3558	Chemical	Gene	production|amod|START_ENTITY production|compound|END_ENTITY	2,5-Deoxyfructosazine , a D-glucosamine derivative , inhibits T-cell interleukin-2 production better than D-glucosamine .
11147780	0	D-glucose	64,73	Bcl-2	23,28	D-glucose	Bcl-2	MESH:D005947	24224(Tax:10116)	Chemical	Gene	exposed|nmod|START_ENTITY exposed|nsubj|Expression Expression|nmod|END_ENTITY	Expression and role of Bcl-2 in rat blastocysts exposed to high D-glucose .
16685426	0	D-glucose	19,28	GLP-1	10,15	D-glucose	GLP-1	MESH:D005947	100125288	Chemical	Gene	transport|amod|START_ENTITY END_ENTITY|nmod|transport	Effect of GLP-1 on D-glucose transport , lipolysis and lipogenesis in adipocytes of obese subjects .
9166676	0	D-glucose	0,9	GLUT1	36,41	D-glucose	GLUT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|nummod|END_ENTITY	D-glucose stimulates mesangial cell GLUT1 expression and basal and IGF-I-sensitive glucose uptake in rat mesangial cells : implications for diabetic_nephropathy .
10419651	0	D-glucose	46,55	Interleukin_1beta	0,17	D-glucose	Interleukin 1beta	MESH:D005947	16176(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY mediates|dobj|effect mediates|nsubj|END_ENTITY	Interleukin_1beta mediates the effect of high D-glucose on the secretion of TNF-alpha by mouse uterine epithelial cells .
8914021	0	D-glucose	37,46	TGF-beta_1	13,23	D-glucose	TGF-beta 1	MESH:D005947	7040	Chemical	Gene	synthesis|nmod|START_ENTITY synthesis|compound|END_ENTITY	Induction of TGF-beta_1 synthesis in D-glucose primed human proximal tubular cells by IL-1_beta and TNF_alpha .
10419651	0	D-glucose	46,55	TNF-alpha	76,85	D-glucose	TNF-alpha	MESH:D005947	21926(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|nmod|END_ENTITY	Interleukin_1beta mediates the effect of high D-glucose on the secretion of TNF-alpha by mouse uterine epithelial cells .
1671193	0	D-glucose	150,159	aminopeptidase	109,123	D-glucose	aminopeptidase	MESH:D005947	10404	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Differential modulation of human small intestinal brush-border membrane hemileaflet fluidity affects leucine aminopeptidase activity and transport of D-glucose and L-glutamate .
12455831	0	D-glucose	81,90	hexokinase_type_III	45,64	D-glucose	hexokinase type III	MESH:D005947	3101	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|END_ENTITY	The overexpressed hexahistidine-tagged human hexokinase_type_III is inhibited by D-glucose .
2182358	0	D-glucose	21,30	insulin	10,17	D-glucose	insulin	MESH:D005947	3630	Chemical	Gene	transport|amod|START_ENTITY Effect|nmod|transport Effect|nmod|END_ENTITY	Effect of insulin on D-glucose transport by human placental brush border membranes .
8342636	4	D-glucose	623,632	mg/100	654,660	D-glucose	mg/100	MESH:D005947	875247(Tax:243273)	Chemical	Gene	concentration|amod|START_ENTITY concentration|nmod|END_ENTITY	Exposure to a D-glucose concentration of 200 mg/100 ml had no effect on vasodilation to ACh .
10494783	0	D-glucose	0,9	tissue-type_plasminogen_activator	37,70	D-glucose	tissue-type plasminogen activator	MESH:D005947	5327	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|synthesis synthesis|nmod|END_ENTITY	D-glucose increases the synthesis of tissue-type_plasminogen_activator -LRB- t-PA -RRB- in human peritoneal mesothelial cells .
10386367	0	D-glutamate	82,93	murI	17,21	D-glutamate	murI	CHEBI:29986	6382267(Tax:562)	Chemical	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Isolation of the murI gene from Brevibacterium_lactofermentum ATCC 13869 encoding D-glutamate racemase .
2483548	0	D-histidine	33,44	substance_P	113,124	D-histidine	substance P	CHEBI:27947	21333(Tax:10090)	Chemical	Gene	antagonize|nsubj|START_ENTITY antagonize|dobj|effects effects|nmod|END_ENTITY	Substance_P analogues containing D-histidine antagonize the behavioural effects of intrathecally co-administered substance_P in mice .
40557	0	D-lysergic_acid_diethylamide	10,38	choline_acetyltransferase	51,76	D-lysergic acid diethylamide	choline acetyltransferase	CHEBI:6605	290567(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|compound|END_ENTITY	Effect of D-lysergic_acid_diethylamide on striatal choline_acetyltransferase activity in the rat .
11254873	0	D-mannoheptulose	0,16	hexokinase	36,46	D-mannoheptulose	hexokinase	null	851167(Tax:4932)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	D-mannoheptulose phosphorylation by hexokinase isoenzymes .
24884664	0	D-mannose	55,64	IL-10	32,37	D-mannose	IL-10	MESH:D008358	25325(Tax:10116)	Chemical	Gene	delivery|nmod|START_ENTITY delivery|compound|END_ENTITY	Improvement of spinal non-viral IL-10 gene delivery by D-mannose as a transgene adjuvant to control chronic neuropathic_pain .
1578372	0	D-methyl-phenylalanyl-prolyl-arginal	93,129	thrombin	73,81	D-methyl-phenylalanyl-prolyl-arginal	thrombin	MESH:C064289	2147	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Pharmacological assessment of the antithrombotic activity of the peptide thrombin inhibitor , D-methyl-phenylalanyl-prolyl-arginal -LRB- GYKI-14766 -RRB- , in a canine model of coronary_artery_thrombosis .
2112569	0	D-penicillamine	44,59	interferon_gamma	81,97	D-penicillamine	interferon gamma	MESH:D010396	3458	Chemical	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	In vitro effects of two gold compounds , and D-penicillamine on the production of interferon_gamma .
6315067	0	D-penicillamine	14,29	myeloperoxidase	39,54	D-penicillamine	myeloperoxidase	MESH:D010396	4353	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of D-penicillamine on human myeloperoxidase , a mechanism for the efficacy of the drug in rheumatoid_arthritis .
3515291	0	D-phenylalanine	0,15	enkephalinase	28,41	D-phenylalanine	enkephalinase	CHEBI:16998	24590(Tax:10116)	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	D-phenylalanine : a putative enkephalinase inhibitor studied in a primate acute pain model .
6128872	0	D-phenylalanine	0,15	enkephalinase	26,39	D-phenylalanine	enkephalinase	CHEBI:16998	4311	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	D-phenylalanine and other enkephalinase inhibitors as pharmacological agents : implications for some important therapeutic application .
23981568	0	D-serine	93,101	A2AR	134,138	D-serine	A2AR	CHEBI:16523	11540(Tax:10090)	Chemical	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Fractalkine -LRB- CX3CL1 -RRB- enhances hippocampal N-methyl-D-aspartate_receptor -LRB- NMDAR -RRB- function via D-serine and adenosine receptor type A2 -LRB- A2AR -RRB- activity .
16452318	0	D-serine	68,76	D-amino_acid_oxidase	30,50	D-serine	D-amino acid oxidase	CHEBI:16523	114027(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY role|nmod|metabolism role|nmod|END_ENTITY	Potential role for astroglial D-amino_acid_oxidase in extracellular D-serine metabolism and cytotoxicity .
24971930	0	D-serine	10,18	ERK	89,92	D-serine	ERK	CHEBI:16523	692466(Tax:7091)	Chemical	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	Effect of D-serine on spermatogenesis and extracellular signal-regulated protein kinase -LRB- ERK -RRB- phosphorylation in the testis of the silkworm , Bombyx_mori .
26553873	0	D-serine	58,66	Serine_Racemase	32,47	D-serine	Serine Racemase	CHEBI:16523	63826	Chemical	Gene	Production|compound|START_ENTITY Production|compound|END_ENTITY	Nuclear Compartmentalization of Serine_Racemase Regulates D-serine Production : Implications for N-methyl-D-aspartate -LRB- NMDA -RRB- Receptor Activation .
10557334	0	D-serine	45,53	Serine_racemase	0,15	D-serine	Serine racemase	CHEBI:16523	63826	Chemical	Gene	synthesizing|xcomp|START_ENTITY enzyme|acl|synthesizing END_ENTITY|dep|enzyme	Serine_racemase : a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission .
15219883	0	D-serine	104,112	Serine_racemase	0,15	D-serine	Serine racemase	CHEBI:16523	63826	Chemical	Gene	gradient|nmod|START_ENTITY transport|nmod|gradient transport|amod|END_ENTITY	Serine_racemase and D-serine transport in human placenta and evidence for a transplacental gradient for D-serine in humans .
15536068	0	D-serine	40,48	Serine_racemase	0,15	D-serine	Serine racemase	CHEBI:16523	63826	Chemical	Gene	levels|amod|START_ENTITY intracellular|dobj|levels intracellular|nsubj|modulates modulates|amod|END_ENTITY	Serine_racemase modulates intracellular D-serine levels through an alpha,beta-elimination activity .
11054547	7	D-serine	904,912	serine_racemase	958,973	D-serine	Serine racemase	CHEBI:16523	63826	Chemical	Gene	synthesis|nmod|START_ENTITY detected|nsubjpass|synthesis detected|nmod|cells cells|acl|transfected transfected|nmod|END_ENTITY	Robust synthesis of D-serine was detected in cells transfected with human serine_racemase , demonstrating the conservation of D-amino_acid metabolism in humans .
11309496	0	D-serine	92,100	serine_racemase	125,140	D-serine	serine racemase	CHEBI:16523	63826	Chemical	Gene	synthesis|amod|START_ENTITY inhibition|nmod|synthesis inhibition|advcl|converting converting|dobj|END_ENTITY	A new strategy to decrease N-methyl-D-aspartate -LRB- NMDA -RRB- receptor coactivation : inhibition of D-serine synthesis by converting serine_racemase into an eliminase .
16182447	0	D-serine	42,50	serine_racemase	14,29	D-serine	serine racemase	CHEBI:16523	63826	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|activity activity|amod|END_ENTITY	Regulation of serine_racemase activity by D-serine and nitric_oxide in human glioblastoma cells .
16714286	0	D-serine	14,22	serine_racemase	81,96	D-serine	serine racemase	CHEBI:16523	63826	Chemical	Gene	levels|amod|START_ENTITY Modulation|nmod|levels Modulation|nmod|END_ENTITY	Modulation of D-serine levels via ubiquitin-dependent proteasomal degradation of serine_racemase .
17293453	0	D-serine	78,86	serine_racemase	28,43	D-serine	serine racemase	CHEBI:16523	63826	Chemical	Gene	formation|amod|START_ENTITY inhibition|nmod|formation mediating|dobj|inhibition END_ENTITY|xcomp|mediating	Nitric_oxide S-nitrosylates serine_racemase , mediating feedback inhibition of D-serine formation .
18603832	0	D-serine	48,56	serine_racemase	132,147	D-serine	serine racemase	CHEBI:16523	303306(Tax:10116)	Chemical	Gene	content|amod|START_ENTITY increases|dobj|content increases|advcl|regulating regulating|dobj|expressions expressions|nmod|END_ENTITY	Long-term treatment with morphine increases the D-serine content in the rat brain by regulating the mRNA and protein expressions of serine_racemase and D-amino_acid_oxidase .
19380732	0	D-serine	25,33	serine_racemase	87,102	D-serine	serine racemase	CHEBI:16523	303306(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY inactivation|nmod|synthesis Feedback|dobj|inactivation Feedback|nmod|translocation translocation|nmod|END_ENTITY	Feedback inactivation of D-serine synthesis by NMDA receptor-elicited translocation of serine_racemase to the membrane .
20493854	0	D-serine	51,59	serine_racemase	25,40	D-serine	serine racemase	CHEBI:16523	27364(Tax:10090)	Chemical	Gene	synthesis|amod|START_ENTITY regulates|dobj|synthesis regulates|nsubj|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation of mouse serine_racemase regulates D-serine synthesis .
21906644	0	D-serine	10,18	serine_racemase	57,72	D-serine	serine racemase	CHEBI:16523	27364(Tax:10090)	Chemical	Gene	Levels|nmod|START_ENTITY Levels|nmod|mice mice|amod|END_ENTITY	Levels of D-serine in the brain and peripheral organs of serine_racemase -LRB- Srr -RRB- knock-out mice .
21939517	0	D-serine	66,74	serine_racemase	18,33	D-serine	serine racemase	CHEBI:16523	303306(Tax:10116)	Chemical	Gene	Overexpression|nmod|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of serine_racemase in retina and overproduction of D-serine in eyes of streptozotocin-induced diabetic_retinopathy .
22990841	0	D-serine	35,43	serine_racemase	64,79	D-serine	serine racemase	CHEBI:16523	27364(Tax:10090)	Chemical	Gene	amounts|nmod|START_ENTITY Alteration|nmod|amounts Alteration|acl|lacking lacking|xcomp|END_ENTITY	Alteration of intrinsic amounts of D-serine in the mice lacking serine_racemase and D-amino_acid_oxidase .
25782690	0	D-serine	49,57	serine_racemase	9,24	D-serine	serine racemase	CHEBI:16523	27364(Tax:10090)	Chemical	Gene	levels|amod|START_ENTITY regulates|dobj|levels regulates|nsubj|END_ENTITY	Neuronal serine_racemase regulates extracellular D-serine levels in the adult mouse hippocampus .
9892700	0	D-serine	68,76	serine_racemase	16,31	D-serine	serine racemase	CHEBI:16523	303306(Tax:10116)	Chemical	Gene	biosynthesis|nmod|START_ENTITY Purification|dep|biosynthesis Purification|nmod|END_ENTITY	Purification of serine_racemase : biosynthesis of the neuromodulator D-serine .
26055638	0	D156844	33,40	DcpS	18,22	D156844	DcpS	null	69305(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|inhibitor inhibitor|compound|END_ENTITY	The effect of the DcpS inhibitor D156844 on the protective action of follistatin in mice with spinal_muscular_atrophy .
16407243	0	D4	38,40	Bcl-2	111,116	D4	Bcl-2	null	596	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	The inflammatory mediator leukotriene D4 induces beta-catenin signaling and its association with antiapoptotic Bcl-2 in intestinal epithelial cells .
20625316	0	D4-F	16,20	ABCA1	24,29	D4-F	ABCA1	null	19	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Contribution of D4-F to ABCA1 expression and cholesterol efflux in THP-1 macrophage-derived foam cells .
20625316	0	D4-F	16,20	THP-1	67,72	D4-F	THP-1	null	2736	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Contribution of D4-F to ABCA1 expression and cholesterol efflux in THP-1 macrophage-derived foam cells .
14710188	0	D4476	0,5	CK1	36,39	D4476	CK1	MESH:C493177	122011	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	D4476 , a cell-permeant inhibitor of CK1 , suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a .
19728363	0	D4Z4	29,33	FSHD	87,91	D4Z4	FSHD	null	2489	Chemical	Gene	changes|nmod|START_ENTITY END_ENTITY|nsubj|changes	Common epigenetic changes of D4Z4 in contraction-dependent and contraction-independent FSHD .
18688177	0	D609	0,4	cytosolic_phospholipase_A2	86,112	D609	cytosolic phospholipase A2	MESH:C046498	525072(Tax:9913)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	D609 , an inhibitor of phosphatidylcholine-specific phospholipase C , inhibits group IV cytosolic_phospholipase_A2 .
14969338	0	DA-11004	25,33	IDPc	47,51	DA-11004	IDPc	MESH:C492688	15926(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Anti-diabetic effects of DA-11004 , a synthetic IDPc inhibitor in high fat high sucrose diet-fed C57BL/6J mice .
22056373	0	DA-1229	0,7	DPP4	28,32	DA-1229	DPP4	MESH:C557982	13482(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	DA-1229 , a novel and potent DPP4 inhibitor , improves insulin resistance and delays the onset of diabetes .
22943970	0	DA-1229	87,94	dipeptidyl_peptidase_IV	98,121	DA-1229	dipeptidyl peptidase IV	MESH:C557982	1803	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Evaluation of the pharmacokinetics , food effect , pharmacodynamics , and tolerability of DA-1229 , a dipeptidyl_peptidase_IV inhibitor , in healthy volunteers : first-in-human study .
25336915	0	DA-1229	67,74	dipeptidyl_peptidase_IV	85,108	DA-1229	dipeptidyl peptidase IV	MESH:C557982	1803	Chemical	Gene	evogliptin|appos|START_ENTITY pharmacokinetics|nmod|evogliptin pharmacokinetics|appos|inhibitor inhibitor|amod|END_ENTITY	Multiple-dose pharmacokinetics and pharmacodynamics of evogliptin -LRB- DA-1229 -RRB- , a novel dipeptidyl_peptidase_IV inhibitor , in healthy volunteers .
26878135	0	DA-1229	0,7	dipeptidyl_peptidase_IV	11,34	DA-1229	dipeptidyl peptidase IV	MESH:C557982	13482(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	DA-1229 , a dipeptidyl_peptidase_IV inhibitor , protects against renal_injury by preventing podocyte damage in an animal model of progressive renal_injury .
11059826	0	DA-8159	72,79	phosphodiesterase_type_5	36,60	DA-8159	phosphodiesterase type 5	MESH:C419664	171115(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Erectogenic effect of the selective phosphodiesterase_type_5 inhibitor , DA-8159 .
16625282	0	DA-8159	65,72	phosphodiesterase_type_5	29,53	DA-8159	phosphodiesterase type 5	MESH:C419664	171115(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Erectile potentials of a new phosphodiesterase_type_5 inhibitor , DA-8159 , in diet-induced obese rats .
21793913	0	DA6034	0,6	mTOR	80,84	DA6034	mTOR	MESH:C121889	21977(Tax:10090)	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|pathway pathway|compound|END_ENTITY	DA6034 promotes gastric epithelial cell migration and wound-healing through the mTOR pathway .
8536221	0	DAB	52,55	rhodanese	28,37	DAB	rhodanese	null	22117(Tax:10090)	Chemical	Gene	liver|nmod|START_ENTITY END_ENTITY|nmod|liver	Mitochondrial and cytosolic rhodanese from liver of DAB treated mice .
11303954	0	DADLE	47,52	enkephalin	62,72	DADLE	enkephalin	MESH:D016308	29237(Tax:10116)	Chemical	Gene	START_ENTITY|appos|analogue analogue|compound|END_ENTITY	Development of novel lipophilic derivatives of DADLE -LRB- leucine enkephalin analogue -RRB- : intestinal permeability characateristics of DADLE derivatives in rats .
16356668	0	DADS	69,73	CYP2E1	78,84	DADS	CYP2E1	MESH:C025953	1571	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|compound|END_ENTITY	Human hepatocytes are protected from ethanol-induced cytotoxicity by DADS via CYP2E1 inhibition .
23233092	0	DADS	0,4	cofilin	49,56	DADS	cofilin	MESH:C025953	1072	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	DADS downregulates the Rac1-ROCK1 / PAK1-LIMK1-ADF / cofilin signaling pathway , inhibiting cell migration and invasion .
10677040	4	DAG	656,659	DGK-1	631,636	DAG	goa-1	null	172505(Tax:6239)	Chemical	Gene	kinase|compound|START_ENTITY END_ENTITY|appos|kinase	The effects of serotonin on synaptic transmission were mediated by GOA-1 -LRB- a Galpha0 subunit -RRB- and DGK-1 -LRB- a diacylglycerol -LSB- DAG -RSB- kinase -RRB- , both of which act in the ventral cord motor neurons .
17162664	0	DAMGO	57,62	CXCR4	23,28	DAMGO	CXCR4	MESH:D020875	7852	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|END_ENTITY	Modulation of neuronal CXCR4 by the micro-opioid agonist DAMGO .
22357543	0	DAN	0,3	BMP2	36,40	DAN	BMP2	CHEBI:73276	29373(Tax:10116)	Chemical	Gene	antagonizes|nsubj|START_ENTITY antagonizes|dobj|END_ENTITY	DAN -LRB- NBL1 -RRB- specifically antagonizes BMP2 and BMP4 and modulates the actions of GDF9 , BMP2 , and BMP4 in the rat ovary .
18662245	0	DAPT	30,34	cdk5	50,54	DAPT	cdk5	MESH:C028145|MESH:C048518	140908(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|activity activity|amod|END_ENTITY	The Notch signaling inhibitor DAPT down-regulates cdk5 activity and modulates the distribution of neuronal cytoskeletal proteins .
1425931	0	DAT-582	37,44	5-HT3_receptor	0,14	DAT-582	5-HT3 receptor	MESH:C073385	79246(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|amod|END_ENTITY	5-HT3_receptor antagonist effects of DAT-582 , -LRB- R -RRB- enantiomer of AS-5370 .
16637709	0	DATS	0,4	iNOS	25,29	DATS	iNOS	null	4843	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|iobj|END_ENTITY	DATS reduces LPS-induced iNOS expression , NO production , oxidative stress , and NF-kappaB activation in RAW 264.7 macrophages .
7903377	0	DAU_6215	0,8	5-HT3-receptor	18,32	DAU 6215	5-HT3-receptor	MESH:C070191	79246(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	DAU_6215 , a novel 5-HT3-receptor antagonist , selectively antagonizes scopolamine-induced deficit in a passive-avoidance task , but not scopolamine-induced hypermotility in rats .
1529806	0	DAU_6215	13,21	5-HT3_receptor	31,45	DAU 6215	5-HT3 receptor	MESH:C070191	79246(Tax:10116)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|appos|antagonist antagonist|amod|END_ENTITY	Influence of DAU_6215 , a novel 5-HT3_receptor antagonist , on the cardiovascular system in anaesthetized and pithed rats .
1582449	0	DAU_6215	23,31	5-HT3_receptor	39,53	DAU 6215	5-HT3 receptor	MESH:C070191	79246(Tax:10116)	Chemical	Gene	treatment|nmod|START_ENTITY treatment|appos|antagonist antagonist|amod|END_ENTITY	Chronic treatment with DAU_6215 , a new 5-HT3_receptor antagonist , causes a selective decrease in the number of spontaneously active dopaminergic neurons in the rat ventral tegmental area .
7617146	0	DAU_6215	108,116	5-HT3_receptor	120,134	DAU 6215	5-HT3 receptor	MESH:C070191	79246(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Selective reduction of extracellular dopamine in the rat nucleus accumbens following chronic treatment with DAU_6215 , a 5-HT3_receptor antagonist .
8115433	0	DAU_6215	10,18	5-HT3_receptor	28,42	DAU 6215	5-HT3 receptor	MESH:C070191	79246(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Effect of DAU_6215 , a novel 5-HT3_receptor antagonist , on scopolamine-induced amnesia in the rat in a spatial learning task .
8295658	0	DAU_6215	0,8	5-HT3_receptor	18,32	DAU 6215	5-HT3 receptor	MESH:C070191	79246(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	DAU_6215 , a novel 5-HT3_receptor antagonist , improves performance in the aged rat in the Morris water maze task .
25749514	0	DC120	0,5	AKT	15,18	DC120	AKT	MESH:C575445	207	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	DC120 , a novel AKT inhibitor , preferentially suppresses nasopharyngeal_carcinoma cancer stem-like cells by downregulating Sox2 .
25749514	0	DC120	0,5	Sox2	122,126	DC120	Sox2	MESH:C575445	6657	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	DC120 , a novel AKT inhibitor , preferentially suppresses nasopharyngeal_carcinoma cancer stem-like cells by downregulating Sox2 .
20888730	0	DC260126	0,8	GPR40	41,46	DC260126	GPR40	null	266607(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|nmod|END_ENTITY	DC260126 , a small-molecule antagonist of GPR40 , improves insulin tolerance but not glucose tolerance in obese Zucker rats .
18206410	8	DCA	1313,1316	PDH	1327,1330	DCA	PDH	null	54704	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Exposure for 24h to 5mM DCA increased PDH activity in non-transduced control -LRB- mean 37 % increase -RRB- and PDH_deficient -LRB- mean 44 % increase -RRB- cells .
12182892	0	DCG-IV	0,6	BDNF	80,84	DCG-IV	BDNF	MESH:C082313	24225(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	DCG-IV but not other group-II metabotropic receptor agonists induces microglial BDNF mRNA expression in the rat striatum .
1875283	0	DCN_203-922	165,176	prolactin	108,117	DCN 203-922	prolactin	MESH:C053770	5617	Chemical	Gene	effect|nmod|START_ENTITY effect|amod|END_ENTITY	Mathematical model for in vivo pharmacodynamics integrating fluctuation of the response : application to the prolactin suppressant effect of the dopaminomimetic drug DCN_203-922 .
23257360	0	DCs	73,76	MYD88	54,59	DCs	MYD88	null	17874(Tax:10090)	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Treg-mediated suppression of atherosclerosis requires MYD88 signaling in DCs .
17106228	0	DDA	11,14	IFN-gamma	53,62	DDA	IFN-gamma	MESH:C000849	396054(Tax:9031)	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of DDA , CpG-ODN , and plasmid-encoded chicken IFN-gamma on protective immunity by a DNA vaccine against IBDV in chickens .
2106687	0	DDAVP	50,55	VIII	101,105	DDAVP	VIII	MESH:D003894	1351	Chemical	Gene	cryoprecipitate|nmod|START_ENTITY stimulation|amod|cryoprecipitate donation|nmod|stimulation donation|dep|source source|nmod|factor factor|nummod|END_ENTITY	Plasma exchange donation of cryoprecipitate after DDAVP stimulation : an alternative source of factor VIII .
2860491	0	DDAVP	63,68	VIII	14,18	DDAVP	VIII	MESH:D003894	1351	Chemical	Gene	analogue|appos|START_ENTITY END_ENTITY|nmod|analogue	Absent factor VIII response to synthetic vasopressin analogue -LRB- DDAVP -RRB- in nephrogenic_diabetes_insipidus .
3918556	0	DDAVP	50,55	VIII	117,121	DDAVP	VIII	MESH:D003894	1351	Chemical	Gene	effect|appos|START_ENTITY END_ENTITY|nsubj|effect	The effect of 1-deamino_8_D-arginine_vasopressin -LRB- DDAVP -RRB- in a nonhaemophilic patient with an acquired type II factor VIII inhibitor .
6777902	0	DDAVP	36,41	VIII	25,29	DDAVP	VIII	MESH:D003894	1351	Chemical	Gene	infusion|compound|START_ENTITY END_ENTITY|nmod|infusion	Properties of the factor VIII after DDAVP -LRB- 1-deamino-8-D-arginine_vasopressin -RRB- infusion in normal subjects .
3118500	0	DDAVP	61,66	factor_VIII	25,36	DDAVP	factor VIII	MESH:D003894	403875(Tax:9615)	Chemical	Gene	concentrations|nmod|START_ENTITY concentrations|nmod|END_ENTITY	Plasma concentrations of factor_VIII after administration of DDAVP to conscious dogs .
489197	0	DDAVP	10,15	renin	26,31	DDAVP	renin	MESH:D003894	5972	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|compound|END_ENTITY	Effect of DDAVP on plasma renin activity in man .
2510348	0	DDAVP	0,5	urokinase-type_plasminogen_activator	34,70	DDAVP	urokinase-type plasminogen activator	MESH:D003894	5328	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|release release|nmod|END_ENTITY	DDAVP induces systemic release of urokinase-type_plasminogen_activator .
23577625	0	DDC	21,24	CYP2E1	4,10	DDC	CYP2E1	CHEBI:10101	1571	Chemical	Gene	START_ENTITY|nsubj|inhibitor inhibitor|compound|END_ENTITY	The CYP2E1 inhibitor DDC up-regulates MMP-1 expression in hepatic stellate cells via an ERK1/2 - and Akt-dependent mechanism .
23577625	7	DDC	1247,1250	ERK1/2	1132,1138	DDC	ERK1/2	CHEBI:10101	5595;5594	Chemical	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	ERK1/2 -LRB- extracellular_signal-regulated_kinase_1 / 2 -RRB- , Akt -LRB- protein_kinase_B -RRB- and p38 were significantly activated by DDC .
7507399	0	DDC	18,21	LHRH	35,39	DDC	LHRH	CHEBI:10101	25194(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY treatment|nmod|END_ENTITY	Effect of chronic DDC treatment on LHRH and substance P amidation processes in the rat .
23577625	0	DDC	21,24	MMP-1	38,43	DDC	MMP-1	CHEBI:10101	4312	Chemical	Gene	START_ENTITY|dobj|expression expression|compound|END_ENTITY	The CYP2E1 inhibitor DDC up-regulates MMP-1 expression in hepatic stellate cells via an ERK1/2 - and Akt-dependent mechanism .
25316167	0	DDE	0,3	AhR	64,67	DDE	AhR	MESH:D003633	196	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|appos|END_ENTITY	DDE and PCB_153 independently induce aryl_hydrocarbon_receptor -LRB- AhR -RRB- expression in peripheral blood mononuclear cells .
22230338	0	DDE	38,41	DDT	14,17	DDE	DDT	MESH:D003633	615999(Tax:9913)	Chemical	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The effect of DDT and its metabolite -LRB- DDE -RRB- on prostaglandin secretion from epithelial cells and on contractions of the smooth muscle of the bovine oviduct in vitro .
22282017	0	DDE	19,22	DDT	14,17	DDE	DDT	MESH:D003633	1652	Chemical	Gene	Assessment|appos|START_ENTITY Assessment|nmod|END_ENTITY	Assessment of DDT , DDE , and_1-hydroxypyrene levels in blood and urine samples in children from Chiapas Mexico .
11134333	0	DDE	4,7	RAG-1	17,22	DDE	RAG-1	MESH:D003633	5896	Chemical	Gene	motif|compound|START_ENTITY motif|nmod|END_ENTITY	The DDE motif in RAG-1 is contributed in trans to a single active site that catalyzes the nicking and transesterification steps of V -LRB- D -RRB- J recombination .
25316167	0	DDE	0,3	aryl_hydrocarbon_receptor	37,62	DDE	aryl hydrocarbon receptor	MESH:D003633	196	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|amod|END_ENTITY	DDE and PCB_153 independently induce aryl_hydrocarbon_receptor -LRB- AhR -RRB- expression in peripheral blood mononuclear cells .
23132776	0	DDT	23,26	COX-2	44,49	DDT	COX-2	MESH:D003634	4513	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|compound|END_ENTITY	Differential effect of DDT , DDE , and DDD on COX-2 expression in the human trophoblast derived HTR-8 / SVneo cells .
15030474	0	DDT	103,106	Cyp6a2	89,95	DDT	Cyp6a2	MESH:D003634	35587(Tax:7227)	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|compound|END_ENTITY	Point mutations associated with insecticide resistance in the Drosophila cytochrome P450 Cyp6a2 enable DDT metabolism .
12144699	0	DDT	93,96	cytochrome_P450	56,71	DDT	cytochrome P450	MESH:D003634	36316(Tax:7227)	Chemical	Gene	genes|nmod|START_ENTITY genes|amod|END_ENTITY	Differential expression and induction of two Drosophila cytochrome_P450 genes near the Rst -LRB- 2 -RRB- DDT locus .
18801367	0	DDT	45,48	estrogen_receptor_alpha	82,105	DDT	estrogen receptor alpha	MESH:D003634	2099	Chemical	Gene	influence|nmod|START_ENTITY influence|nmod|END_ENTITY	The influence of non-toxic concentrations of DDT and DDE on the old world vulture estrogen_receptor_alpha .
16696175	0	DDT	25,28	interleukin-2	53,66	DDT	interleukin-2	MESH:D003634	3558	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Coumestrol , bisphenol-A , DDT , and TCDD modulation of interleukin-2 expression in activated CD +4 Jurkat T cells .
16382143	0	DEAH	30,34	Prp43p	20,26	DEAH	Prp43p	null	1665	Chemical	Gene	ATPase|compound|START_ENTITY END_ENTITY|appos|ATPase	The splicing factor Prp43p , a DEAH box ATPase , functions in ribosome biogenesis .
14751452	0	DEET	39,43	acetylcholinesterase	116,136	DEET	acetylcholinesterase	MESH:D003671	83817(Tax:10116)	Chemical	Gene	permethrin|amod|START_ENTITY Co-exposure|nmod|permethrin causes|nsubj|Co-exposure causes|dobj|deficit deficit|nmod|activity activity|compound|END_ENTITY	Co-exposure to pyridostigmine_bromide , DEET , and/or permethrin causes sensorimotor deficit and alterations in brain acetylcholinesterase activity .
26985901	0	DEHP	29,33	PPARy	42,47	DEHP	PPARy	MESH:D004051	5468	Chemical	Gene	Response|nmod|START_ENTITY Response|nmod|END_ENTITY	The Inflammation Response to DEHP through PPARy in Endometrial Cells .
1394843	7	DEN	1274,1277	mouse	1257,1262	DEN	K-ras	CHEBI:34873	16653(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Therefore , _ lung_tumors from the A/J mouse induced by DEN and ENU could be initiated by the interaction of reactive metabolites with specific sites in the K-ras gene .
22179681	0	DENSPM	26,32	SSAT	18,22	DENSPM	SSAT	MESH:C059685	6303	Chemical	Gene	treatment|compound|START_ENTITY END_ENTITY|nmod|treatment	Overexpression of SSAT by DENSPM treatment induces cell detachment and apoptosis in glioblastoma .
11683179	0	DES	104,107	p38	85,88	DES	p38	CHEBI:37628	5594	Chemical	Gene	stimulation|nmod|START_ENTITY stimulation|amod|END_ENTITY	Differential activation of MAPK during M __ llerian_duct growth and apoptosis : JNK and p38 stimulation by DES blocks tissue death .
7418660	0	DES	30,33	prolactin	54,63	DES	prolactin	CHEBI:37628	19109(Tax:10090)	Chemical	Gene	treatment|compound|START_ENTITY effects|nmod|treatment effects|nmod|END_ENTITY	Long-term effects of neonatal DES treatment on plasma prolactin in female mice .
9574835	0	DEX	169,172	VIP	194,197	DEX	VIP	null	7432	Chemical	Gene	modulation|nmod|START_ENTITY modulation|nmod|END_ENTITY	A suppressive effect of dexamethasone -LRB- DEX -RRB- on adrenocorticotropin -LRB- ACTH -RRB- response to vasoactive intestinal peptide -LRB- VIP -RRB- in Cushing 's _ disease : a parallel modulation by DEX of ACTH responses to VIP and corticotropin-releasing_hormone .
26592483	0	DF2755A	0,7	CXCR1/2	57,64	DF2755A	CXCR1/2	null	3577;3579	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	DF2755A , a novel non-competitive allosteric inhibitor of CXCR1/2 , reduces inflammatory and post-operative pain .
16397051	0	DFU	82,85	cyclooxygenase-2	54,70	DFU	cyclooxygenase-2	null	29527(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Mechanical analysis of tumor growth regression by the cyclooxygenase-2 inhibitor , DFU , in a Walker256 rat tumor model : importance of monocyte_chemoattractant_protein-1 modulation .
17985314	0	DFU	83,86	cyclooxygenase-2	100,116	DFU	cyclooxygenase-2	null	29527(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Association of maternal pancreatic function and foetal growth in rats treated with DFU , a selective cyclooxygenase-2 inhibitor .
15585326	0	DFU	31,34	vascular_endothelial_growth_factor	45,79	DFU	vascular endothelial growth factor	null	7422	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	New cyclooxygenase-2 inhibitor DFU regulates vascular_endothelial_growth_factor expression in rheumatoid_synoviocytes .
18362895	0	DF_2162	15,22	CXCR1/2	66,73	DF 2162	CXCR1/2	MESH:C528719	227288;12765	Chemical	Gene	Treatment|nmod|START_ENTITY Treatment|appos|inhibitor inhibitor|nmod|END_ENTITY	Treatment with DF_2162 , a non-competitive allosteric inhibitor of CXCR1/2 , diminishes neutrophil influx and inflammatory hypernociception in mice .
12673795	0	DGGE	40,44	ATRX	27,31	DGGE	ATRX	null	546	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Mutational analysis of the ATRX gene by DGGE : a powerful diagnostic approach for the ATRX_syndrome .
18801371	0	DH-PH	4,9	UNC-89	38,44	DH-PH	UNC-89	null	171990(Tax:6239)	Chemical	Gene	region|amod|START_ENTITY region|nmod|END_ENTITY	The DH-PH region of the giant protein UNC-89 activates RHO-1 GTPase in Caenorhabditis_elegans body wall muscle .
19855194	0	DH166	0,5	PLK1	68,72	DH166	PLK1	MESH:C551241	5347	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	DH166 , a beta-carboline derivative , inhibits the kinase activity of PLK1 .
16677716	0	DH82	91,95	interleukin-6	63,76	DH82	interleukin-6	null	403985(Tax:9615)	Chemical	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Effect of dehydroepiandrosterone on lipopolysaccharide-induced interleukin-6 production in DH82 cultured canine macrophage cells .
21367920	10	DHA	1316,1319	NF-kB	1384,1389	DHA	NF-kB	CHEBI:16016	81736(Tax:10116)	Chemical	Gene	decreased|nsubj|START_ENTITY decreased|dobj|expression expression|nmod|END_ENTITY	DHA and EPA decreased p-ERK expression and nuclear translocation of NF-kB , both of which are necessary for TNF-a-stimulated MCP-1 expression .
2143469	0	DHA-S	11,16	3_beta-hydroxysteroid_dehydrogenase	30,65	DHA-S	3 beta-hydroxysteroid dehydrogenase	MESH:C027493	3283	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|concentrations concentrations|amod|END_ENTITY	Effects of DHA-S on placental 3_beta-hydroxysteroid_dehydrogenase activity , progesterone and 20 alpha-dihydroprogesterone concentrations in placenta and serum .
21565288	1	DHBP	173,177	RIB3	188,192	DHBP	RIB3	null	852098(Tax:4932)	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Reversible S-glutathionylation of DHBP synthase -LRB- RIB3 -RRB- .
17643555	0	DHEA	20,24	3beta-HSD	0,9	DHEA	3beta-HSD	MESH:D003687	3283	Chemical	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	3beta-HSD activates DHEA in the songbird brain .
17503469	0	DHEA	60,64	Androgen_receptor	0,17	DHEA	Androgen receptor	MESH:D003687	367	Chemical	Gene	-|compound|START_ENTITY -|dep|END_ENTITY	Androgen_receptor or estrogen receptor-beta blockade alters DHEA - , DHT - , and E -LRB- 2 -RRB- - induced proliferation and PSA production in human prostate_cancer cells .
12482595	0	DHEA	116,120	DHEA-S	139,145	DHEA	DHEA-S	MESH:D003687	6822	Chemical	Gene	dehydroepiandrosterone|appos|START_ENTITY dehydroepiandrosterone|appos|END_ENTITY	In vivo activation of the constitutive androstane receptor beta -LRB- CARbeta -RRB- by treatment with dehydroepiandrosterone -LRB- DHEA -RRB- or DHEA sulfate -LRB- DHEA-S -RRB- .
14586159	0	DHEA	99,103	DHEA-S	141,147	DHEA	DHEA-S	MESH:D003687	6822	Chemical	Gene	dehydroepiandrosterone|appos|START_ENTITY dehydroepiandrosterone|appos|END_ENTITY	Three-month treatment course of methylphenidate increases plasma levels of dehydroepiandrosterone -LRB- DHEA -RRB- and dehydroepiandrosterone-sulfate -LRB- DHEA-S -RRB- in attention_deficit_hyperactivity_disorder .
22430044	0	DHEA	10,14	IGF-1	40,45	DHEA	IGF-1	MESH:D003687	3479	Chemical	Gene	Effect|nmod|START_ENTITY supplementation|nsubj|Effect supplementation|nmod|END_ENTITY	Effect of DHEA supplementation on serum IGF-1 , osteocalcin , and bone mineral density in postmenopausal , glucocorticoid-treated women .
11167994	0	DHEA	61,65	IL-6	128,132	DHEA	IL-6	MESH:D003687	3569	Chemical	Gene	dehydroepiandrosterone|appos|START_ENTITY effect|nmod|dehydroepiandrosterone studies|nmod|effect studies|dep|expression expression|amod|END_ENTITY	Preliminary studies on the effect of dehydroepiandrosterone -LRB- DHEA -RRB- on both constitutive and phytohaemagglutinin -LRB- PHA -RRB- - inducible IL-6 and IL-2 mRNA expression and cytokine production in human spleen mononuclear cell suspensions in vitro .
21729423	0	DHEA	50,54	IL-6	75,79	DHEA	IL-6	MESH:D003687	3569	Chemical	Gene	dehydroepiandrosterone|appos|START_ENTITY dehydroepiandrosterone|appos|END_ENTITY	Increased serum levels of dehydroepiandrosterone -LRB- DHEA -RRB- and interleukin-6 -LRB- IL-6 -RRB- in women with mild to moderate Alzheimer 's _ disease .
9626133	0	DHEA	116,120	IL-6	130,134	DHEA	IL-6	MESH:D003687	3569	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|compound|END_ENTITY	Serum dehydroepiandrosterone -LRB- DHEA -RRB- and DHEA_sulfate are negatively correlated with serum interleukin-6 -LRB- IL-6 -RRB- , and DHEA inhibits IL-6 secretion from mononuclear cells in man in vitro : possible link between endocrinosenescence and immunosenescence .
9626133	0	DHEA	30,34	IL-6	105,109	DHEA	IL-6	MESH:D003687	3569	Chemical	Gene	dehydroepiandrosterone|appos|START_ENTITY correlated|nsubjpass|dehydroepiandrosterone correlated|nmod|interleukin-6 interleukin-6|appos|END_ENTITY	Serum dehydroepiandrosterone -LRB- DHEA -RRB- and DHEA_sulfate are negatively correlated with serum interleukin-6 -LRB- IL-6 -RRB- , and DHEA inhibits IL-6 secretion from mononuclear cells in man in vitro : possible link between endocrinosenescence and immunosenescence .
15934093	0	DHEA	87,91	Tumor_necrosis_factor	0,21	DHEA	Tumor necrosis factor	MESH:D003687	7124	Chemical	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	Tumor_necrosis_factor inhibits conversion of dehydroepiandrosterone_sulfate -LRB- DHEAS -RRB- to DHEA in rheumatoid_arthritis synovial cells : a prerequisite for local androgen_deficiency .
18036596	0	DHEA	20,24	VIP	64,67	DHEA	VIP	MESH:D003687	7432	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nsubj|effects	Combined effects of DHEA and fadrozole on aggression and neural VIP immunoreactivity in the non-breeding male song sparrow .
16990659	0	DHEA-sulfate	10,22	adiponectin	26,37	DHEA-sulfate	adiponectin	MESH:D019314	9370	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of DHEA-sulfate on adiponectin gene expression in adipose tissue from different fat depots in morbidly obese humans .
17381481	7	DHEAS	1015,1020	IGF-I	1052,1057	DHEAS	DHEAS	CHEBI:16814	6822	Chemical	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	DHEAS was positively associated with IGF-I and negatively with age , in both men and women .
9268186	0	DHG	55,58	tissue_factor_pathway_inhibitor	63,94	DHG	tissue factor pathway inhibitor	null	7035	Chemical	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of depolymerized holothurian glycosaminoglycan -LRB- DHG -RRB- on tissue_factor_pathway_inhibitor : in vitro and in vivo studies .
23900151	0	DHMEQ	88,93	HMGB1	67,72	DHMEQ	HMGB1	null	15289(Tax:10090)	Chemical	Gene	suppression|nmod|START_ENTITY suppression|compound|END_ENTITY	Efficacy of DHMEQ , a NF-kB inhibitor , in islet transplantation : I. HMGB1 suppression by DHMEQ prevents early islet graft damage .
17310217	0	DHMEQ	70,75	IkappaBalpha	0,12	DHMEQ	IkappaBalpha	null	18035(Tax:10090)	Chemical	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	IkappaBalpha independent induction of NF-kappaB and its inhibition by DHMEQ in Hodgkin/Reed-Sternberg cells .
15956280	0	DHMEQ	75,80	NF-kappaB	118,127	DHMEQ	NF-kappaB	null	4790	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Dual targeting of transformed and untransformed HTLV-1-infected T cells by DHMEQ , a potent and selective inhibitor of NF-kappaB , as a strategy for chemoprevention and therapy of adult T-cell_leukemia .
16211219	0	DHMEQ	91,96	NF-kappaB	101,110	DHMEQ	NF-kappaB	null	4790	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Enhancement of the caspase-independent apoptotic sensitivity of pancreatic_cancer cells by DHMEQ , an NF-kappaB inhibitor .
16525497	0	DHMEQ	0,5	NF-kappaB	13,22	DHMEQ	NF-kappaB	null	4790	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	DHMEQ , a new NF-kappaB inhibitor , induces apoptosis and enhances fludarabine effects on chronic_lymphocytic_leukemia cells .
16865289	0	DHMEQ	0,5	NF-kappaB	15,24	DHMEQ	NF-kappaB	null	4790	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	DHMEQ , a novel NF-kappaB inhibitor , induces apoptosis and cell-cycle arrest in human hepatoma cells .
17310217	0	DHMEQ	70,75	NF-kappaB	38,47	DHMEQ	NF-kappaB	null	18033(Tax:10090)	Chemical	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	IkappaBalpha independent induction of NF-kappaB and its inhibition by DHMEQ in Hodgkin/Reed-Sternberg cells .
19275643	5	DHMEQ	857,862	NF-kappaB	836,845	DHMEQ	NF-kappaB	null	4790	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	A novel NF-kappaB inhibitor , DHMEQ -LRB- dehydroxymethylepoxyquinomicin -RRB- , inhibits the translocation of NF-kappaB into the nucleus as well as inhibits DNA binding of NF-kappaB components and was shown to be a potent chemo - and immuno-sensitizing agent and in combination with cytotoxic therapeutics resulted in significant reversal of resistance and tumor cell death .
17192695	0	DHMEQ	32,37	NFkappaB	12,20	DHMEQ	NFkappaB	null	18033(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	A selective NFkappaB inhibitor , DHMEQ , reduced atherosclerosis in ApoE-deficient mice .
18385532	0	DHMEQ	11,16	nuclear_factor-kappab	26,47	DHMEQ	nuclear factor-kappab	null	4790	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|inhibitor inhibitor|amod|END_ENTITY	Effects of DHMEQ , a novel nuclear_factor-kappab inhibitor , on beta cell dysfunction in INS-1 cells .
12047400	0	DHT	44,47	HSL	18,21	DHT	HSL	CHEBI:16330	3991	Chemical	Gene	expression|nmod|START_ENTITY expression|nsubj|regulation regulation|nmod|END_ENTITY	The regulation of HSL and LPL expression by DHT and flutamide in human subcutaneous adipose tissue .
16368782	0	DHT	0,3	IGF-I	66,71	DHT	IGF-I	CHEBI:16330	3479	Chemical	Gene	modulate|nsubj|START_ENTITY modulate|dobj|END_ENTITY	DHT and testosterone , but not DHEA or E2 , differentially modulate IGF-I , IGFBP-2 , and IGFBP-3 in human prostatic stromal cells .
25347962	0	DHT	0,3	Seladin-1	60,69	DHT	Seladin-1	CHEBI:16330	1718	Chemical	Gene	Inhibits|nsubj|START_ENTITY Inhibits|nmod|Regulation Regulation|nmod|bax bax|compound|END_ENTITY	DHT Inhibits the Ab25-35-Induced Apoptosis by Regulation of Seladin-1 , Survivin , XIAP , bax , and bcl-xl Expression Through a Rapid PI3-K/Akt Signaling in C6 Glial Cell Lines .
25347962	0	DHT	0,3	bax	87,90	DHT	bax	CHEBI:16330	581	Chemical	Gene	Inhibits|nsubj|START_ENTITY Inhibits|nmod|Regulation Regulation|nmod|END_ENTITY	DHT Inhibits the Ab25-35-Induced Apoptosis by Regulation of Seladin-1 , Survivin , XIAP , bax , and bcl-xl Expression Through a Rapid PI3-K/Akt Signaling in C6 Glial Cell Lines .
1482343	0	DIDS	29,33	TNF-alpha	63,72	DIDS	TNF-alpha	MESH:D017878	7124	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|nmod|END_ENTITY	The stilbene_disulfonic_acid DIDS stimulates the production of TNF-alpha in human lymphocytes .
15574364	0	DIM	57,60	AKT	76,79	DIM	AKT	CHEBI:50182	207	Chemical	Gene	effects|nmod|START_ENTITY mediated|nsubjpass|effects mediated|nmod|END_ENTITY	Selective growth regulatory and pro-apoptotic effects of DIM is mediated by AKT and NF-kappaB pathways in prostate_cancer cells .
15735741	0	DIM	0,3	IFNgamma	15,23	DIM	IFNgamma	CHEBI:50182	3458	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	DIM stimulates IFNgamma gene expression in human breast_cancer cells via the specific activation of JNK and p38 pathways .
19470787	5	DIM	1083,1086	p75	1067,1070	DIM	NTR	CHEBI:50182	4923	Chemical	Gene	treatment|compound|START_ENTITY END_ENTITY|nmod|treatment	Transfection of the PC-3 prostate cell line with a dominant-negative form of p75 -LRB- NTR -RRB- before DIM treatment significantly rescued cell survival demonstrating a cause and effect relationship between DIM induction of p75 -LRB- NTR -RRB- levels and inhibition of survival .
19470787	5	DIM	1187,1190	p75	1067,1070	DIM	NTR	CHEBI:50182	4923	Chemical	Gene	induction|compound|START_ENTITY relationship|nmod|induction demonstrating|dobj|relationship rescued|xcomp|demonstrating rescued|nsubj|Transfection Transfection|nmod|line line|nmod|form form|nmod|END_ENTITY	Transfection of the PC-3 prostate cell line with a dominant-negative form of p75 -LRB- NTR -RRB- before DIM treatment significantly rescued cell survival demonstrating a cause and effect relationship between DIM induction of p75 -LRB- NTR -RRB- levels and inhibition of survival .
12414442	0	DITPA	0,5	bFGF	17,21	DITPA	bFGF	null	54250(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	DITPA stimulates bFGF , VEGF , angiopoietin , and Tie-2 and facilitates coronary arteriolar growth .
6416746	0	DL-alpha-difluoro-methylornithine	29,62	ornithine_decarboxylase	93,116	DL-alpha-difluoro-methylornithine	ornithine decarboxylase	null	4953	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|inhibitor inhibitor|nmod|END_ENTITY	Contragestational effects of DL-alpha-difluoro-methylornithine , an irreversible inhibitor of ornithine_decarboxylase , in the hamster .
3101528	0	DL-alpha-difluoromethylornithine	50,82	ornithine_decarboxylase	15,38	DL-alpha-difluoromethylornithine	ornithine decarboxylase	null	4953	Chemical	Gene	inhibitors|dobj|START_ENTITY inhibitors|nsubj|Effects Effects|nmod|END_ENTITY	Effects of the ornithine_decarboxylase inhibitors DL-alpha-difluoromethylornithine and alpha-monofluoromethyldehydroornithine_methyl_ester alone and in combination with suramin against Trypanosoma_brucei_brucei_central_nervous_system_models .
18645008	0	DMAG	17,21	HSP90	0,5	DMAG	HSP90	null	3320	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|nummod|END_ENTITY	HSP90 inhibitor , DMAG , synergizes with radiation of lung_cancer cells by interfering with base excision and ATM-mediated DNA repair .
25893034	0	DMAT	50,54	CK2	36,39	DMAT	CK2	null	13000(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Inhibitor Inhibitor|compound|END_ENTITY	Tenfibgen-DMAT Nanocapsule Delivers CK2 Inhibitor DMAT to Prostate_Cancer Xenograft Tumors Causing Inhibition of Cell Proliferation .
25893034	0	DMAT	50,54	CK2	36,39	DMAT	CK2	null	13000(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Inhibitor Inhibitor|compound|END_ENTITY	Tenfibgen-DMAT Nanocapsule Delivers CK2 Inhibitor DMAT to Prostate_Cancer Xenograft Tumors Causing Inhibition of Cell Proliferation .
24199196	0	DMBA	52,56	connexin_43	60,71	DMBA	connexin 43	MESH:D015127	14609(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Higher incidence of lung_adenocarcinomas induced by DMBA in connexin_43 heterozygous knockout mice .
25247550	0	DMH1	0,4	Akt	53,56	DMH1	Akt	null	24185(Tax:10116)	Chemical	Gene	Metabolism|compound|START_ENTITY Metabolism|nmod|END_ENTITY	DMH1 Increases Glucose Metabolism through Activating Akt in L6 Rat Skeletal Muscle Cells .
11927182	0	DMP696	41,47	CRF	25,28	DMP696	CRF	MESH:C404928	81648(Tax:10116)	Chemical	Gene	Effects|appos|START_ENTITY Effects|nmod|antagonist antagonist|compound|END_ENTITY	Effects of a non-peptide CRF antagonist -LRB- DMP696 -RRB- on the behavioral and endocrine sequelae of maternal separation .
7811738	0	DMPC	14,18	phospholipase_A2	41,57	DMPC	phospholipase A2	MESH:D004134	151056	Chemical	Gene	Hydrolysis|nmod|START_ENTITY Hydrolysis|nmod|END_ENTITY	Hydrolysis of DMPC or DPPC by pancreatic phospholipase_A2 is slowed down when -LRB- perfluoroalkyl -RRB- alkanes are incorporated into the liposomal membrane .
9831902	0	DMPPO	10,15	phosphodiesterase_type_5	19,43	DMPPO	phosphodiesterase type 5	CHEBI:63412	171115(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effect of DMPPO , a phosphodiesterase_type_5 inhibitor , on hypoxic pulmonary hypertension in rats .
21745495	0	DMQ	12,15	clk-1	44,49	DMQ	clk-1	null	175729(Tax:6239)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of DMQ -LRB- 9 -RRB- in the long-lived mutant clk-1 .
17762443	0	DMSA	120,124	Calcitonin_Gene-Related_Peptide	22,53	DMSA	Calcitonin Gene-Related Peptide	MESH:D004113	796	Chemical	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	The potential role of Calcitonin_Gene-Related_Peptide -LRB- CGRP -RRB- in breast carcinogenesis and its correlation with 99mTc - -LRB- V -RRB- DMSA scintimammography .
8456058	0	DMSO	73,77	5-Lipoxygenase	0,14	DMSO	5-Lipoxygenase	MESH:D004121	240	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	5-Lipoxygenase gene expression in HL60 cells during differentiation with DMSO .
9716453	0	DMSO	0,4	CSF-1_receptor	13,27	DMSO	CSF-1 receptor	MESH:D004121	12978(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|levels levels|compound|END_ENTITY	DMSO reduces CSF-1_receptor levels and causes apoptosis in v-myc immortalized mouse macrophages .
3127594	3	DMSO	648,652	H-2Kk	619,624	DMSO	Thy-1	MESH:D004121	21838(Tax:10090)	Chemical	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	H-2Kk and H-2Dd induction by DMSO was equal to pretreatment of YAC-1 cells with 50-100 and 10-20 U/ml interferon -LRB- IFN -RRB- - gamma , respectively , but the T-cell differentiation antigens Lyt-1 , Lyt-2 , Thy-1 , and L3T4 remained unaffected .
1464282	0	DN-1417	25,32	thyrotropin-releasing_hormone	50,79	DN-1417	thyrotropin-releasing hormone	MESH:C029762	25569(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|derivative derivative|nmod|END_ENTITY	Anticonvulsant effect of DN-1417 , a derivative of thyrotropin-releasing_hormone , and liposome-entrapped DN-1417 , on amygdaloid-kindled rats .
2986054	0	DN-1417	10,17	thyrotropin-releasing_hormone	31,60	DN-1417	thyrotropin-releasing hormone	MESH:C029762	25569(Tax:10116)	Chemical	Gene	START_ENTITY|appos|analogue analogue|amod|END_ENTITY	Effect of DN-1417 , a synthetic thyrotropin-releasing_hormone analogue , on -LSB- 3H -RSB- GABA binding in the cerebellum of ataxic rats .
3035097	0	DN-1417	22,29	thyrotropin-releasing_hormone	73,102	DN-1417	thyrotropin-releasing hormone	MESH:C029762	25569(Tax:10116)	Chemical	Gene	Lack|nmod|START_ENTITY Lack|nmod|END_ENTITY	Lack of usefulness of DN-1417 for characterization of a CNS receptor for thyrotropin-releasing_hormone .
3081836	0	DN-1417	57,64	thyrotropin-releasing_hormone	17,46	DN-1417	thyrotropin-releasing hormone	MESH:C029762	25569(Tax:10116)	Chemical	Gene	Effects|appos|START_ENTITY Effects|nmod|analogue analogue|amod|END_ENTITY	Effects of a new thyrotropin-releasing_hormone analogue -LRB- DN-1417 -RRB- on evoked responses and long-term potentiation in the dentate gyrus of rat .
6428117	0	DN-1417	82,89	thyrotropin-releasing_hormone	35,64	DN-1417	thyrotropin-releasing hormone	MESH:C029762	25569(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	In vitro thyrotrophin release with thyrotropin-releasing_hormone and an analogue , DN-1417 .
6434294	0	DN-1417	79,86	thyrotropin-releasing_hormone	25,54	DN-1417	thyrotropin-releasing hormone	MESH:C029762	7200	Chemical	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Antiepileptic effects of thyrotropin-releasing_hormone and its new derivative , DN-1417 , examined in feline amygdaloid kindling preparation .
6439851	0	DN-1417	83,90	thyrotropin-releasing_hormone	106,135	DN-1417	thyrotropin-releasing hormone	MESH:C029762	25569(Tax:10116)	Chemical	Gene	gamma-butyrolactone-gamma-carbonyl-L-histidyl-L-prolinamide_citrate|appos|START_ENTITY Absorption|nmod|gamma-butyrolactone-gamma-carbonyl-L-histidyl-L-prolinamide_citrate Absorption|appos|analog analog|nmod|END_ENTITY	Absorption of gamma-butyrolactone-gamma-carbonyl-L-histidyl-L-prolinamide_citrate -LRB- DN-1417 -RRB- , an analog of thyrotropin-releasing_hormone , in rats and dogs .
17643252	5	DNCB	1031,1035	CD4	1044,1047	DNCB	CD4	MESH:D004137	404704(Tax:9823)	Chemical	Gene	proliferation|compound|START_ENTITY proliferation|compound|END_ENTITY	Treatment of DCs with PS liposomes also suppressed DNCB induced CD4 + T cell proliferation and IFN-gamma production .
15871903	0	DNCP	93,97	TGFbeta-1	45,54	DNCP	TGFbeta-1	null	7040	Chemical	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of transforming_growth_factor_beta1 -LRB- TGFbeta-1 -RRB- and dentin non-collagenous proteins -LRB- DNCP -RRB- on human embryonic ectomesenchymal cells in a three-dimensional culture system .
15896946	0	DNFB	0,4	CD40	37,41	DNFB	CD40	MESH:D004139	21939(Tax:10090)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	DNFB activates MAPKs and upregulates CD40 in skin-derived dendritic cells .
10819899	6	DNQX	1455,1459	Fos	1421,1424	DNQX	Fos	MESH:C056723	314322(Tax:10116)	Chemical	Gene	due|nmod|START_ENTITY due|nsubj|expression expression|compound|END_ENTITY	In 6-OHDA-lesioned rats , systemic injections of the DA D1 receptor agonist SKF38393 -LRB- 0.5 mg/kg , i.p. -RRB- increased striatal Fos expression due to intranigral DNQX .
8741770	0	DNQX	14,18	Fos	49,52	DNQX	Fos	MESH:C056723	314322(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Intrastriatal DNQX induces rotation and pallidal Fos in the 6-OHDA model of Parkinson 's _ disease .
3311501	0	DOCA	14,18	renin	56,61	DOCA	renin	MESH:D003900	24715(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|content content|compound|END_ENTITY	The effect of DOCA and 9_alpha-fludrocortisone on renal renin content and production .
9931125	0	DOCA-salt	27,36	ACE	10,13	DOCA-salt	ACE	null	11421(Tax:10090)	Chemical	Gene	inhibitor|nmod|START_ENTITY inhibitor|compound|END_ENTITY	Effect of ACE inhibitor on DOCA-salt - and aortic_coarctation-induced hypertension in mice : do kinin_B2 receptors play a role ?
23159275	0	DOI	45,48	5-HT2A	18,24	DOI	5-HT2A	null	29595(Tax:10116)	Chemical	Gene	effect|dep|START_ENTITY effect|nmod|END_ENTITY	The effect of the 5-HT2A / 2C receptor agonist DOI on micturition in rats with chronic spinal_cord_injury .
23380172	0	DOI	34,37	5-HT2A	0,6	DOI	5-HT2A	null	3356	Chemical	Gene	alleviates|compound|START_ENTITY alleviates|nummod|END_ENTITY	5-HT2A serotonin receptor agonist DOI alleviates cytotoxicity in neuroblastoma cells : role of the ERK pathway .
880865	0	DOPA	9,13	acetylcholinesterase	41,61	DOPA	acetylcholinesterase	MESH:D004295	83817(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY END_ENTITY|nsubj|Role	-LSB- Role of DOPA and dopamine in activating acetylcholinesterase in rat neostriatum -RSB- .
1473213	0	DOPAC	93,98	dopamine_D-1_and_D-2	16,36	DOPAC	dopamine D-1 and D-2	MESH:D015102	29484(Tax:10116)	Chemical	Gene	effects|appos|START_ENTITY effects|nmod|antagonists antagonists|amod|END_ENTITY	-LSB- The effects of dopamine_D-1_and_D-2 receptor antagonists on 3,4-dihydroxyphenylacetic _ acid -LRB- DOPAC -RRB- in rat striatum with differential normal pulse voltammetry -RSB- .
18818058	0	DOPC	42,46	PLA2	34,38	DOPC	PLA2	MESH:C017251	5319	Chemical	Gene	substrates|compound|START_ENTITY END_ENTITY|nmod|substrates	Comparative study of lipolysis by PLA2 of DOPC substrates organized as monolayers , bilayer vesicles and nanocapsules .
24378707	0	DOTA	1,5	Somatostatin-14	6,21	DOTA	Somatostatin-14	CHEBI:61028	6750	Chemical	Gene	analogs|compound|START_ENTITY analogs|compound|END_ENTITY	-LSB- DOTA -RSB- Somatostatin-14 analogs and their -LRB- 111 -RRB- In-radioligands : effects of decreasing ring-size on sst1-5 profile , stability and tumor targeting .
26214576	0	DOTAM-alkyl	71,82	Tm3	66,69	DOTAM-alkyl	Tm3	null	22003(Tax:10090)	Chemical	Gene	complexes|compound|START_ENTITY complexes|amod|END_ENTITY	Introduction of peripheral carboxylates to decrease the charge on Tm3 + DOTAM-alkyl complexes : Implications for de-tection sensitivity and in vivo toxicity of PARACEST MRI contrast agents .
17452449	0	DOUBLETIME	2,12	PERIOD	53,59	DOUBLETIME	PERIOD	null	31251(Tax:7227)	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|protein protein|compound|END_ENTITY	A DOUBLETIME kinase binding domain on the Drosophila PERIOD protein is essential for its hyperphosphorylation , transcriptional repression , and circadian clock function .
19442784	6	DOX	781,784	MMP-9	807,812	DOX	MMP-2	null	4313	Chemical	Gene	decreased|nsubj|START_ENTITY decreased|dobj|END_ENTITY	DOX decreased endometrial MMP-9 at 1 and 6 months compared to baseline and PL -LRB- p < .05 -RRB- .
25725375	0	DPA-714	19,26	translocator_protein	62,82	DPA-714	translocator protein	MESH:C530129	24230(Tax:10116)	Chemical	Gene	analogues|nmod|START_ENTITY analogues|nmod|END_ENTITY	Ether analogues of DPA-714 with subnanomolar affinity for the translocator_protein -LRB- TSPO -RRB- .
12751387	8	DPD	847,850	RCC	874,877	DPD	DPD	null	1806	Chemical	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	DPD activity in Stage I/II RCC was approximately 2-fold higher than that in Stage III/IV RCC .
18355441	0	DPPC	0,4	COX-2	15,20	DPPC	COX-2	CHEBI:40265	4513	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	DPPC regulates COX-2 expression in monocytes via phosphorylation of CREB .
24289115	0	DQ786243	7,15	CREB	37,41	DQ786243	CREB	null	1385	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|END_ENTITY	LncRNA DQ786243 affects Treg related CREB and Foxp3 expression in Crohn 's _ disease .
2481522	0	DRB	34,37	nucleolin	75,84	DRB	nucleolin	MESH:D004004	4691	Chemical	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The effect of adenosine analogue -LRB- DRB -RRB- on a major nucleolar phosphoprotein nucleolin .
12877572	0	DRF-4367	45,53	COX-2	61,66	DRF-4367	COX-2	MESH:C482791	26198(Tax:10116)	Chemical	Gene	bioavailability|nmod|START_ENTITY bioavailability|appos|inhibitor inhibitor|compound|END_ENTITY	Oral bioavailability and pharmacokinetics of DRF-4367 , a new COX-2 inhibitor in rats .
15326524	0	DRF-4367	95,103	COX-2	123,128	DRF-4367	COX-2	MESH:C482791	4513	Chemical	Gene	benzenesulfonamide|appos|START_ENTITY 2-hydroxymethyl-4|dep|benzenesulfonamide 2-hydroxymethyl-4|dep|inhibitor inhibitor|compound|END_ENTITY	2-hydroxymethyl-4 - -LSB- 5 - -LRB- 4-methoxyphenyl -RRB- -3 - trifluoromethyl-1H-1-pyrazolyl -RSB- -1 - benzenesulfonamide -LRB- DRF-4367 -RRB- : an orally active COX-2 inhibitor identified through pharmacophoric modulation .
17315542	0	DRF-4367	51,59	COX-2	69,74	DRF-4367	COX-2	MESH:C482791	4513	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Glucuronidation of DRF-6574 , hydroxy metabolite of DRF-4367 -LRB- a novel COX-2 inhibitor -RRB- by pooled human liver , intestinal microsomes and recombinant human UDP-glucuronosyltransferases -LRB- UGT -RRB- : role of UGT1A1 , 1A3 and 1A8 .
16019950	0	DRF_4367	27,35	COX-2	45,50	DRF 4367	COX-2	MESH:C482791	17709(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Pre-clinical assessment of DRF_4367 , a novel COX-2 inhibitor : evaluation of pharmacokinetics , absolute oral bioavailability and metabolism in mice and comparative inter-species in vitro metabolism .
9463471	0	DRNFLRFamide	87,99	Protein_kinase_C	0,16	DRNFLRFamide	Protein kinase C	MESH:C088642	112476	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Protein_kinase_C is required for long-lasting synaptic enhancement by the neuropeptide DRNFLRFamide in crayfish .
20415690	0	DSP-7238	26,34	DPP_IV	86,92	DSP-7238	DPP IV	null	13482(Tax:10090)	Chemical	Gene	administration|nmod|START_ENTITY administration|appos|inhibitor inhibitor|compound|END_ENTITY	Chronic administration of DSP-7238 , a novel , potent , specific and substrate-selective DPP_IV inhibitor , improves glycaemic control and beta-cell damage in diabetic mice .
23269193	0	DTCM-G	29,35	mTOR	62,66	DTCM-G	mTOR	null	21977(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Immunosuppressive effects of DTCM-G , a novel inhibitor of the mTOR downstream signaling pathway .
16928136	5	DTGC	706,710	tyrosinase	741,751	DTGC	tyrosinase	null	7299	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|dobj|END_ENTITY	The results showed that DTGC significantly inhibited human tyrosinase in a complex manner -LRB- slope-parabolic mixed-type inhibition -RRB- , which was comparable to mushroom tyrosinase .
15970518	6	DTX	830,833	p53	868,871	DTX	p53	null	7157	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|nmod|END_ENTITY	Interestingly , we have found that DTX reduces the expression of mutated p53 in HT-29 and increases the expression of wild type in KB and HCC1937 cells .
20106953	0	DUF283	43,49	DCL4	38,42	DUF283	DCL4	null	832154(Tax:3702)	Chemical	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	Structure of the Arabidopsis_thaliana DCL4 DUF283 domain reveals a noncanonical double-stranded RNA-binding fold for protein-protein interaction .
1358253	0	DUP_753	57,64	angiotensin_II	30,44	DUP 753	angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	properties|appos|START_ENTITY properties|nmod|antagonist antagonist|amod|END_ENTITY	Antianxiety properties of the angiotensin_II antagonist , DUP_753 , in the rat using the elevated plus-maze .
9219625	0	DV-7028	10,17	serotonin_5-HT2_receptor	27,51	DV-7028	serotonin 5-HT2 receptor	MESH:C073727	29595(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|antagonist antagonist|amod|END_ENTITY	Effect of DV-7028 , a novel serotonin_5-HT2_receptor antagonist on the cardiovascular system in rats .
24361696	0	DW09849	0,7	PI3K	52,56	DW09849	PI3K	null	5293	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|appos|END_ENTITY	DW09849 , a selective phosphatidylinositol_3-kinase -LRB- PI3K -RRB- inhibitor , prevents PI3K signaling and preferentially inhibits proliferation of cells containing the oncogenic mutation p110a -LRB- H1047R -RRB- .
24361696	0	DW09849	0,7	phosphatidylinositol_3-kinase	21,50	DW09849	phosphatidylinositol 3-kinase	null	5293	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	DW09849 , a selective phosphatidylinositol_3-kinase -LRB- PI3K -RRB- inhibitor , prevents PI3K signaling and preferentially inhibits proliferation of cells containing the oncogenic mutation p110a -LRB- H1047R -RRB- .
26806300	0	DW10075	0,7	VEGFR	59,64	DW10075	VEGFR	null	3791	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	DW10075 , a novel selective and small-molecule inhibitor of VEGFR , exhibits antitumor activities both in vitro and in vivo .
15815881	0	DX-9065a	95,103	factor_Xa	128,137	DX-9065a	factor Xa	MESH:C086910	2159	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Vascular endothelial tissue_factor_pathway_inhibitor kinetics in culture following exposure to DX-9065a -- a selective and direct factor_Xa inhibitor .
8983124	0	DX-9065a	87,95	factor_Xa	66,75	DX-9065a	factor Xa	MESH:C086910	2159	Chemical	Gene	effect|amod|START_ENTITY effect|nmod|END_ENTITY	The antithrombotic effect of synthetic low molecular weight human factor_Xa inhibitor , DX-9065a , on He-Ne laser-induced thrombosis in rat mesenteric microvessels .
20178811	8	DX600	1497,1502	ACE2	1507,1511	DX600	ACE2	null	302668(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Moreover , PASMCs from 6-month exposed rats proliferated more rapidly than those from 3-month exposed or control rats , and cells grew even more rapidly in the presence of DX600 , an ACE2 inhibitor .
15741800	0	DX9065a	159,166	thrombin	220,228	DX9065a	thrombin	MESH:C086910	2147	Chemical	Gene	Determination|nmod|START_ENTITY Determination|nmod|END_ENTITY	Determination of prothombinase activation after adding human purified prothrombin to human clot : comparison of hirudin , an activated factor II inhibitor , with DX9065a , an activated factor X inhibitor , on clot-associated thrombin and on prothrombin activation .
18636161	0	DXR	175,178	Bax	62,65	DXR	Bax	null	581	Chemical	Gene	association|nmod|START_ENTITY association|nmod|END_ENTITY	The association of deamidation of Bcl-xL and translocation of Bax to the mitochondria through activation of JNK in the induction of apoptosis by treatment with GSH-conjugated DXR .
18636161	0	DXR	175,178	Bcl-xL	34,40	DXR	Bcl-xL	null	598	Chemical	Gene	association|nmod|START_ENTITY association|nmod|END_ENTITY	The association of deamidation of Bcl-xL and translocation of Bax to the mitochondria through activation of JNK in the induction of apoptosis by treatment with GSH-conjugated DXR .
18636161	0	DXR	175,178	JNK	108,111	DXR	JNK	null	5599	Chemical	Gene	association|nmod|START_ENTITY association|nmod|END_ENTITY	The association of deamidation of Bcl-xL and translocation of Bax to the mitochondria through activation of JNK in the induction of apoptosis by treatment with GSH-conjugated DXR .
16049129	0	DY-9760e	49,57	p450	246,250	DY-9760e	p450	MESH:C109602	1555	Chemical	Gene	metabolism|nmod|START_ENTITY involvement|nmod|metabolism involvement|nmod|END_ENTITY	In vitro metabolism of the calmodulin antagonist DY-9760e -LRB- 3 - -LSB- 2 - -LSB- 4 - -LRB- 3-chloro-2-methylphenyl -RRB- -1 - piperazinyl -RSB- ethyl -RSB- -5,6 - dimethoxy-1 - -LRB- 4-imidazolylmethyl -RRB- -1 H-indazole_dihydrochloride_3 .5 _ hydrate -RRB- by human liver microsomes : involvement of cytochromes p450 in atypical kinetics and potential drug interactions .
22761044	0	DYZ-2-90	0,8	JNK	134,137	DYZ-2-90	JNK	null	5599	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|activating activating|dobj|END_ENTITY	DYZ-2-90 , a novel neo-tanshinlactone ring-opened compound , induces ERK-mediated mitotic_arrest and subsequent apoptosis by activating JNK in human colorectal_cancer cells .
24374810	0	DZ2002	23,29	SAHH	44,48	DZ2002	SAHH	MESH:C509291	269378(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Therapeutic effects of DZ2002 , a reversible SAHH inhibitor , on lupus-prone NZB NZW F1 mice via interference with TLR-mediated APC response .
25023204	0	Dabigatran	41,51	Thrombin	22,30	Dabigatran	Thrombin	MESH:C554682	29251(Tax:10116)	Chemical	Gene	Pressure|compound|START_ENTITY Pressure|compound|END_ENTITY	Oral Warfarin and the Thrombin Inhibitor Dabigatran Increase Blood Pressure in Rats : Hidden Danger of Anticoagulants ?
25502064	0	Dabigatran	12,22	Thrombin	44,52	Dabigatran	Thrombin	MESH:C554682	14061(Tax:10090)	Chemical	Gene	Effects|compound|START_ENTITY Reversal|nmod|Effects Reversal|nmod|Generation Generation|compound|END_ENTITY	Reversal of Dabigatran Effects in Models of Thrombin Generation and Hemostasis by Factor VIIa and Prothrombin Complex Concentrate .
25918026	0	Dabigatran	17,27	Thrombin	72,80	Dabigatran	Thrombin	MESH:C554682	2147	Chemical	Gene	Concentration|compound|START_ENTITY Concentration|nmod|Assessed Assessed|acl|Using Using|dobj|Assay Assay|compound|END_ENTITY	Relation Between Dabigatran Concentration , as Assessed Using the Direct Thrombin Inhibitor Assay , and Activated Clotting Time/Activated Partial Thromboplastin Time in Patients With Atrial_Fibrillation .
25918026	0	Dabigatran	17,27	Thrombin	72,80	Dabigatran	Thrombin	MESH:C554682	2147	Chemical	Gene	Concentration|compound|START_ENTITY Concentration|nmod|Assessed Assessed|acl|Using Using|dobj|Assay Assay|compound|END_ENTITY	Relation Between Dabigatran Concentration , as Assessed Using the Direct Thrombin Inhibitor Assay , and Activated Clotting Time/Activated Partial Thromboplastin Time in Patients With Atrial_Fibrillation .
22494098	0	Dabigatran	0,10	ribosyldihydronicotinamide_dehydrogenase	60,100	Dabigatran	ribosyldihydronicotinamide dehydrogenase	MESH:C554682	4835	Chemical	Gene	START_ENTITY|dep|inhibitors inhibitors|nmod|END_ENTITY	Dabigatran and dabigatran_ethyl_ester : potent inhibitors of ribosyldihydronicotinamide_dehydrogenase -LRB- NQO2 -RRB- .
19877031	0	Dabigatran	0,10	thrombin	21,29	Dabigatran	thrombin	MESH:C554682	2147	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Dabigatran , a direct thrombin inhibitor , demonstrates antifibrotic effects on lung fibroblasts .
20671233	0	Dabigatran	0,10	thrombin	68,76	Dabigatran	thrombin	MESH:C554682	2147	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	Dabigatran : an oral novel potent reversible nonpeptide inhibitor of thrombin .
21533567	0	Dabigatran	0,10	thrombin	27,35	Dabigatran	thrombin	MESH:C554682	2147	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Dabigatran : an oral direct thrombin inhibitor for use in atrial_fibrillation .
23242974	0	Dabigatran	0,10	thrombin	22,30	Dabigatran	thrombin	MESH:C554682	2147	Chemical	Gene	generation|compound|START_ENTITY generation|compound|END_ENTITY	Dabigatran attenuates thrombin generation to a lesser extent than warfarin : could this explain their differential effects on intracranial_hemorrhage and myocardial_infarction ?
23690810	0	Dabigatran	0,10	thrombin	21,29	Dabigatran	thrombin	MESH:C554682	2147	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Dabigatran , a direct thrombin inhibitor , can be a life-saving treatment in heparin-induced thrombocytopenia .
23920075	0	Dabigatran	16,26	thrombin	37,45	Dabigatran	thrombin	MESH:C554682	2147	Chemical	Gene	Implications|nmod|START_ENTITY Implications|appos|inhibitor inhibitor|compound|END_ENTITY	Implications of Dabigatran , a direct thrombin inhibitor , for oral surgery practice .
25669912	0	Dabigatran	0,10	thrombin	72,80	Dabigatran	thrombin	MESH:C554682	14061(Tax:10090)	Chemical	Gene	abrogates|nsubj|START_ENTITY abrogates|nmod|END_ENTITY	Dabigatran abrogates brain endothelial cell permeability in response to thrombin .
25981140	0	Dabigatran	38,48	thrombin	60,68	Dabigatran	thrombin	MESH:C554682	2147	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|generation generation|compound|END_ENTITY	From laboratory to clinical practice : Dabigatran effects on thrombin generation and coagulation in patient samples .
25981140	0	Dabigatran	38,48	thrombin	60,68	Dabigatran	thrombin	MESH:C554682	2147	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|generation generation|compound|END_ENTITY	From laboratory to clinical practice : Dabigatran effects on thrombin generation and coagulation in patient samples .
26320153	0	Dabigatran	38,48	thrombin	19,27	Dabigatran	thrombin	MESH:C554682	14061(Tax:10090)	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|Effect Effect|nmod|END_ENTITY	Effect of the oral thrombin inhibitor Dabigatran on allergic_lung_inflammation induced by repeated house dust mite administration in mice .
15333033	0	Dabigatran_etexilate	160,180	thrombin	50,58	Dabigatran etexilate	thrombin	MESH:C453962	2147	Chemical	Gene	inhibitor|nsubj|START_ENTITY escalating|parataxis|inhibitor escalating|dobj|study study|nmod|inhibitor inhibitor|compound|END_ENTITY	Dose escalating safety study of a new oral direct thrombin inhibitor , dabigatran_etexilate , in patients undergoing total hip replacement : BISTRO I. BACKGROUND : Dabigatran_etexilate -LRB- BIBR_1048 -RRB- is an oral direct thrombin inhibitor undergoing evaluation for the prevention of venous_thromboembolism -LRB- VTE -RRB- following total hip replacement .
17729188	0	Dabigatran_etexilate	0,20	thrombin	24,32	Dabigatran etexilate	thrombin	MESH:C453962	2147	Chemical	Gene	inhibitor|advmod|START_ENTITY inhibitor|nsubj|END_ENTITY	Dabigatran_etexilate , a thrombin inhibitor for the prevention of venous_thromboembolism and stroke .
18956996	0	Dabigatran_etexilate	0,20	thrombin	37,45	Dabigatran etexilate	thrombin	MESH:C453962	2147	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Dabigatran_etexilate : an oral direct thrombin inhibitor for prophylaxis and treatment of thromboembolic_diseases .
20352166	0	Dabigatran_etexilate	0,20	thrombin	55,63	Dabigatran etexilate	thrombin	MESH:C453962	2147	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Dabigatran_etexilate -- a novel , reversible , oral direct thrombin inhibitor : interpretation of coagulation assays and reversal of anticoagulant activity .
20367591	0	Dabigatran_etexilate	0,20	thrombin	28,36	Dabigatran etexilate	thrombin	MESH:C453962	2147	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Dabigatran_etexilate : a new thrombin inhibitor .
20446854	0	Dabigatran_etexilate	0,20	thrombin	40,48	Dabigatran etexilate	thrombin	MESH:C453962	2147	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Dabigatran_etexilate , a new oral direct thrombin inhibitor , for stroke prevention in patients with atrial_fibrillation .
21540406	0	Dabigatran_etexilate	0,20	thrombin	35,43	Dabigatran etexilate	thrombin	MESH:C453962	2147	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Dabigatran_etexilate : a novel oral thrombin inhibitor for thromboembolic_disease .
21817082	0	Dabigatran_etexilate	0,20	thrombin	42,50	Dabigatran etexilate	thrombin	MESH:C453962	2147	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Dabigatran_etexilate : A novel oral direct thrombin inhibitor .
22444784	0	Dabigatran_etexilate	0,20	thrombin	37,45	Dabigatran etexilate	thrombin	MESH:C453962	2147	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Dabigatran_etexilate : an oral direct thrombin inhibitor for the management of thromboembolic_disorders .
23031422	0	Dabrafenib	25,35	BRAF	61,65	Dabrafenib	BRAF	MESH:C561627	673	Chemical	Gene	START_ENTITY|nmod|malignant_melanoma malignant_melanoma|amod|patient patient|nmod|END_ENTITY	Overwhelming response to Dabrafenib in a patient with double BRAF mutation -LRB- V600E ; V600M -RRB- metastatic malignant_melanoma .
23846776	1	Dabrafenib	142,152	BRAF	231,235	Dabrafenib	BRAF	MESH:C561627	673	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Dabrafenib is an orally bioavailable , potent , and selective inhibitor of human wild-type BRAF and CRAF kinases as well as mutant forms of BRAF kinase .
24971404	0	Dabrafenib	0,10	BRAF	37,41	Dabrafenib	BRAF	MESH:C561627	673	Chemical	Gene	START_ENTITY|nmod|mutation mutation|compound|END_ENTITY	Dabrafenib in advanced melanoma with BRAF V600E mutation .
25014231	0	Dabrafenib	0,10	BRAF	32,36	Dabrafenib	BRAF	MESH:C561627	673	Chemical	Gene	START_ENTITY|nmod|treatment treatment|nmod|melanoma melanoma|compound|END_ENTITY	Dabrafenib for the treatment of BRAF V600-positive melanoma : a safety evaluation .
25287827	0	Dabrafenib	15,25	BRAF	144,148	Dabrafenib	BRAF	MESH:C561627	673	Chemical	Gene	BRAF|appos|START_ENTITY BRAF|acl|experiencing experiencing|nmod|inhibitor inhibitor|amod|END_ENTITY	Combined BRAF -LRB- Dabrafenib -RRB- and MEK inhibition -LRB- Trametinib -RRB- in patients with BRAFV600-mutant melanoma experiencing progression with single-agent BRAF inhibitor .
25488880	0	Dabrafenib	22,32	BRAF	76,80	Dabrafenib	BRAF	MESH:C561627	673	Chemical	Gene	Effectiveness|nmod|START_ENTITY Effectiveness|nmod|Patients Patients|nmod|Unresectable Unresectable|compound|END_ENTITY	Cost Effectiveness of Dabrafenib as a First-Line Treatment in Patients with BRAF V600 Mutation-Positive Unresectable or Metastatic_Melanoma in Canada .
25651238	0	Dabrafenib	41,51	BRAF	9,13	Dabrafenib	BRAF	MESH:C561627	673	Chemical	Gene	Treatment|compound|START_ENTITY Melanomas|dep|Treatment Melanomas|compound|END_ENTITY	Multiple BRAF Wild-Type Melanomas During Dabrafenib Treatment for Metastatic BRAF-Mutant Melanoma .
25795886	0	Dabrafenib	94,104	BRAF	30,34	Dabrafenib	BRAF	MESH:C561627	673	Chemical	Gene	found|nmod|START_ENTITY found|nsubj|LBA2Investigation LBA2Investigation|nmod|mutations mutations|compound|END_ENTITY	LBA2Investigation of non-V600 BRAF mutations commonly found in NSCLC for their sensitivity to Dabrafenib or Trametinib .
25839886	0	Dabrafenib	74,84	BRAF	58,62	Dabrafenib	BRAF	MESH:C561627	673	Chemical	Gene	Therapy|appos|START_ENTITY Therapy|compound|END_ENTITY	Panniculitis With Necrotizing Granulomata in a Patient on BRAF Inhibitor -LRB- Dabrafenib -RRB- Therapy for Metastatic_Melanoma .
26392102	0	Dabrafenib	38,48	BRAF	67,71	Dabrafenib	BRAF	MESH:C561627	673	Chemical	Gene	BRAF|nmod|START_ENTITY BRAF|nmod|Colorectal_Cancer Colorectal_Cancer|compound|END_ENTITY	Combined BRAF and MEK Inhibition With Dabrafenib and Trametinib in BRAF V600-Mutant Colorectal_Cancer .
27080216	0	Dabrafenib	0,10	BRAF	28,32	Dabrafenib	BRAF	MESH:C561627	673	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	Dabrafenib in patients with BRAF -LRB- V600E -RRB- - positive advanced non-small-cell_lung_cancer : a single-arm , multicentre , open-label , phase 2 trial .
17986791	0	Daedalin_A	24,34	tyrosinase	2,12	Daedalin A	tyrosinase	MESH:C526356	7299	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	A tyrosinase inhibitor , Daedalin_A , from mycelial culture of Daedalea dickinsii .
21992804	0	Daedalols_A-C	0,13	BACE1	30,35	Daedalols A-C	BACE1	null	23621	Chemical	Gene	START_ENTITY|appos|inhibitors inhibitors|compound|END_ENTITY	Daedalols_A-C , fungal-derived BACE1 inhibitors .
22057127	0	Dafadine	0,8	DAF-9	18,23	Dafadine	DAF-9	null	180889(Tax:6239)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis_elegans .
26558782	0	Daidzein	0,8	ApoE	46,50	Daidzein	ApoE	MESH:C004742	348	Chemical	Gene	Homeostasis|compound|START_ENTITY Homeostasis|nmod|END_ENTITY	Daidzein Augments Cholesterol Homeostasis via ApoE to Promote Functional Recovery in Chronic_Stroke .
24632845	0	Daidzein	0,8	Cxcl2	47,52	Daidzein	Cxcl2	MESH:C004742	20310(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	Daidzein suppresses pro-inflammatory chemokine Cxcl2 transcription in TNF-a-stimulated murine lung epithelial cells via depressing PARP-1 activity .
20708703	0	Daidzein	0,8	mucin	64,69	Daidzein	mucin	MESH:C004742	100508689	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Daidzein regulates secretion , production and gene expression of mucin from airway epithelial cells stimulated by proinflammatory factor and growth factor .
22725099	0	Dalcetrapib	0,11	cholesteryl_ester_transfer_protein	16,50	Dalcetrapib	cholesteryl ester transfer protein	MESH:C411602	1071	Chemical	Gene	START_ENTITY|appos|modulator modulator|compound|END_ENTITY	Dalcetrapib , a cholesteryl_ester_transfer_protein modulator .
20472439	0	Dammaranes	0,10	protein_tyrosine_phosphatase_1B	92,123	Dammaranes	protein tyrosine phosphatase 1B	null	5770	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Dammaranes from Gynostemma pentaphyllum and synthesis of their derivatives as inhibitors of protein_tyrosine_phosphatase_1B .
26048912	0	Danazol	0,7	Cytochrome_P450_2J2	17,36	Danazol	Cytochrome P450 2J2	MESH:D003613	1573	Chemical	Gene	Inhibits|nsubj|START_ENTITY Inhibits|dobj|Activity Activity|amod|END_ENTITY	Danazol Inhibits Cytochrome_P450_2J2 Activity in a Substrate-independent Manner .
1311660	0	Danazol	0,7	insulin	35,42	Danazol	insulin	MESH:D003613	3630	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Danazol induces resistance to both insulin and glucagon in young women .
19463751	0	Dansyl-PQRamide	0,15	NPFF	42,46	Dansyl-PQRamide	NPFF	MESH:C402061	60337(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|nmod|receptors receptors|compound|END_ENTITY	Dansyl-PQRamide , a putative antagonist of NPFF receptors , reduces anxiety-like behavior of ethanol withdrawal in a plus-maze test in rats .
11835998	0	Dansyl-PQRamide	0,15	neuropeptide_FF	28,43	Dansyl-PQRamide	neuropeptide FF	MESH:C402061	60337(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Dansyl-PQRamide , a possible neuropeptide_FF receptor antagonist , induces conditioned place preference .
24764253	0	Dantrolene	42,52	Acetylcholinesterase	18,38	Dantrolene	Acetylcholinesterase	MESH:D003620	43	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	The Inhibition of Acetylcholinesterase by Dantrolene and Ondansetron .
9341133	0	Dantrolene	0,10	Ca2	48,51	Dantrolene	Ca2	MESH:D003620	100154873(Tax:9823)	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Dantrolene inhibition of sarcoplasmic reticulum Ca2 + release by direct and specific action at skeletal_muscle_ryanodine_receptors .
25920678	0	Dantrolene	50,60	RyR	32,35	Dantrolene	RyR	MESH:D003620	20190(Tax:10090)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|compound|END_ENTITY	Essential Role of Calmodulin in RyR Inhibition by Dantrolene .
11236903	0	Dantrolene	0,10	TNFalpha	25,33	Dantrolene	TNFalpha	MESH:D003620	24835(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	Dantrolene reduces serum TNFalpha and corticosterone levels and muscle calcium , calpain gene expression , and protein breakdown in septic rats .
18981569	0	Dantrolene	0,10	glutathione_reductase	38,59	Dantrolene	glutathione reductase	MESH:D003620	2936	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Dantrolene inhibits human erythrocyte glutathione_reductase .
1522747	0	Dantrolene	0,10	renin	22,27	Dantrolene	renin	MESH:D003620	24715(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|compound|END_ENTITY	Dantrolene stimulates renin secretion by rat renal cortical slices but fails to block calcium-dependent inhibition .
24444523	0	Dapagliflozin	1,14	SGLT-2	26,32	Dapagliflozin	SGLT-2	MESH:C529054	6524	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	-LSB- Dapagliflozin , the first SGLT-2 inhibitor in the treatment of type 2 diabetes -RSB- .
18356408	0	Dapagliflozin	0,13	SGLT2	27,32	Dapagliflozin	SGLT2	MESH:C529054	64522(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Dapagliflozin , a selective SGLT2 inhibitor , improves glucose homeostasis in normal and diabetic rats .
19129748	0	Dapagliflozin	0,13	SGLT2	23,28	Dapagliflozin	SGLT2	MESH:C529054	6524	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Dapagliflozin , a novel SGLT2 inhibitor , induces dose-dependent glucosuria in healthy subjects .
19129749	0	Dapagliflozin	0,13	SGLT2	34,39	Dapagliflozin	SGLT2	MESH:C529054	6524	Chemical	Gene	START_ENTITY|appos|novel novel|appos|inhibitor inhibitor|compound|END_ENTITY	Dapagliflozin , a novel , selective SGLT2 inhibitor , improved glycemic control over 2 weeks in patients with type_2_diabetes_mellitus .
20609956	0	Dapagliflozin	0,13	SGLT2	18,23	Dapagliflozin	SGLT2	MESH:C529054	6524	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Dapagliflozin , an SGLT2 inhibitor , for diabetes .
23724409	0	Dapagliflozin	0,13	SGLT2	18,23	Dapagliflozin	SGLT2	MESH:C529054	6524	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Dapagliflozin , an SGLT2 inhibitor for the treatment of type 2 diabetes .
25694411	0	Dapagliflozin	0,13	sodium-glucose_cotransporter_2	21,51	Dapagliflozin	sodium-glucose cotransporter 2	MESH:C529054	6524	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Dapagliflozin : A new sodium-glucose_cotransporter_2 inhibitor for treatment of type 2 diabetes .
22392830	0	Dapagliflozin	0,13	sodium-glucose_cotransporter_type_2	23,58	Dapagliflozin	sodium-glucose cotransporter type 2	MESH:C529054	6524	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Dapagliflozin : a novel sodium-glucose_cotransporter_type_2 inhibitor for the treatment of type 2 diabetes_mellitus .
21436242	0	Dapsone	0,7	IL-8	17,21	Dapsone	IL-8	MESH:D003622	3576	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|compound|END_ENTITY	Dapsone inhibits IL-8 secretion from human bronchial epithelial cells stimulated with lipopolysaccharide and resolves airway inflammation in the ferret .
19664375	0	Darapladib	0,10	lipoprotein-associated_phospholipase_A2	46,85	Darapladib	lipoprotein-associated phospholipase A2	MESH:C529040	7941	Chemical	Gene	plaque|amod|START_ENTITY plaque|dep|target target|nsubj|END_ENTITY	Darapladib and atherosclerotic plaque : should lipoprotein-associated_phospholipase_A2 be a therapeutic target ?
19790016	0	Darapladib	0,10	lipoprotein-associated_phospholipase_A2	25,64	Darapladib	lipoprotein-associated phospholipase A2	MESH:C529040	7941	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Darapladib , a reversible lipoprotein-associated_phospholipase_A2 inhibitor , for the oral treatment of atherosclerosis and coronary_artery_disease .
23754514	0	Darexaban	0,9	factor_Xa	34,43	Darexaban	factor Xa	MESH:C569750	2159	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Darexaban -LRB- YM150 -RRB- , an oral direct factor_Xa inhibitor , has no effect on the pharmacokinetics of digoxin .
20383201	0	Dasatinib	0,9	Ack1	82,86	Dasatinib	Ack1	MESH:C488369	10188	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Dasatinib inhibits site-specific tyrosine phosphorylation of androgen_receptor by Ack1 and Src kinases .
25418056	0	Dasatinib	42,51	BCRP	74,78	Dasatinib	BCRP	MESH:C488369	9429	Chemical	Gene	Inhibition|compound|START_ENTITY Inhibition|nmod|END_ENTITY	Ingredients in Fruit Juices Interact with Dasatinib Through Inhibition of BCRP : A New Mechanism of Beverage-Drug Interaction .
23888243	0	Dasatinib	56,65	SMAD4	87,92	Dasatinib	SMAD4	MESH:C488369	4089	Chemical	Gene	START_ENTITY|nmod|Mutation Mutation|compound|END_ENTITY	Recurrent Gastrointestinal_Hemorrhage in Treatment with Dasatinib in a Patient Showing SMAD4 Mutation with Acute Lymphoblastic_Leukemia Philadelphia Positive and Juvenile_Polyposis Hereditary Hemorrhagic_Telangiectasia Syndrome .
20226597	0	Dasatinib	0,9	SRC	20,23	Dasatinib	SRC	MESH:C488369	6714	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Dasatinib : a potent SRC inhibitor in clinical development for the treatment of solid tumors .
24407585	0	Dasatinib	0,9	SRC	138,141	Dasatinib	SRC	MESH:C488369	6714	Chemical	Gene	interacts|nsubj|START_ENTITY interacts|nmod|docetaxel docetaxel|nmod|cells cells|nmod|activation activation|compound|END_ENTITY	Dasatinib -LRB- BMS-35482 -RRB- interacts synergistically with docetaxel , gemcitabine , topotecan , and doxorubicin in ovarian_cancer cells with high SRC pathway activation and protein expression .
20585448	7	Dasatinib	1299,1308	STAT5	1282,1287	Dasatinib	STAT5	MESH:C488369	6776	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Similarly , the NF-kappaB inhibitor , BMS-345541 , and the STAT5 inhibitor , Dasatinib , significantly enhanced cell sensitivity to carboplatin .
20406945	0	Dasatinib	0,9	Src	128,131	Dasatinib	Src	MESH:C488369	6714	Chemical	Gene	active|nsubj|START_ENTITY active|nmod|transitional_cell_carcinoma transitional_cell_carcinoma|nmod|urothelium urothelium|nmod|signaling signaling|compound|END_ENTITY	Dasatinib is preclinically active against Src-overexpressing human transitional_cell_carcinoma of the urothelium with activated Src signaling .
21226671	0	Dasatinib	0,9	Src	36,39	Dasatinib	Src	MESH:C488369	6714	Chemical	Gene	START_ENTITY|dep|agent agent|nmod|inhibition inhibition|compound|END_ENTITY	Dasatinib : an anti-tumour agent via Src inhibition .
23142123	0	Dasatinib	0,9	Src	45,48	Dasatinib	Src	MESH:C488369	6714	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|kinase kinase|compound|END_ENTITY	Dasatinib , a small molecule inhibitor of the Src kinase , reduces the growth and activates apoptosis in pre-neoplastic Barrett 's _ esophagus cell lines : evidence for a noninvasive treatment of high-grade dysplasia .
25975261	0	Dasatinib	0,9	Src	78,81	Dasatinib	Src	MESH:C488369	20779(Tax:10090)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|signaling signaling|compound|END_ENTITY	Dasatinib enhances antitumor activity of paclitaxel in ovarian_cancer through Src signaling .
17431118	0	Dasatinib	0,9	Stat5	32,37	Dasatinib	Stat5	MESH:C488369	6776	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Dasatinib -LRB- BMS-354825 -RRB- inhibits Stat5 signaling associated with apoptosis in chronic_myelogenous_leukemia cells .
19786067	0	Dasatinib	0,9	TNF-alpha	36,45	Dasatinib	TNF-alpha	MESH:C488369	21926(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|nmod|END_ENTITY	Dasatinib inhibits the secretion of TNF-alpha following TLR stimulation in vitro and in vivo .
20383201	0	Dasatinib	0,9	androgen_receptor	61,78	Dasatinib	androgen receptor	MESH:C488369	367	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Dasatinib inhibits site-specific tyrosine phosphorylation of androgen_receptor by Ack1 and Src kinases .
25083322	0	Dasatinib	0,9	granzyme_B	41,51	Dasatinib	granzyme B	MESH:C488369	3002	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Dasatinib promotes Th1-type responses in granzyme_B expressing T-cells .
17268817	0	Dasatinib	0,9	src	65,68	Dasatinib	src	MESH:C488369	6714	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Dasatinib , an orally active small molecule inhibitor of both the src and abl kinases , selectively inhibits growth of basal-type / `` triple-negative '' breast_cancer cell lines growing in vitro .
18158072	0	Dasatinib	0,9	tyrosine_kinase	13,28	Dasatinib	tyrosine kinase	MESH:C488369	7294	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Dasatinib : a tyrosine_kinase inhibitor for the treatment of chronic_myelogenous_leukemia and philadelphia_chromosome-positive_acute_lymphoblastic_leukemia .
25864625	0	Daucosterol	0,11	IGF1	106,110	Daucosterol	IGF1	MESH:C011015	3479	Chemical	Gene	protects|nsubj|START_ENTITY protects|advcl|activating activating|dobj|END_ENTITY	Daucosterol protects neurons against oxygen-glucose deprivation/reperfusion-mediated injury by activating IGF1 signaling pathway .
9148901	0	Daunorubicin	0,12	NFkappaB	23,31	Daunorubicin	NFkappaB	MESH:D003630	4790	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Daunorubicin activates NFkappaB and induces kappaB-dependent gene expression in HL-60 promyelocytic and Jurkat T_lymphoma cells .
19236267	0	Debio_025	43,52	cyclophilin	21,32	Debio 025	cyclophilin	MESH:C509971	9360	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|evaluation evaluation|nmod|END_ENTITY	An evaluation of the cyclophilin inhibitor Debio_025 and its potential as a treatment for chronic hepatitis_C .
24604074	0	Debio_0932	0,10	hsp90	23,28	Debio 0932	hsp90	null	3320	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Debio_0932 , a new oral hsp90 inhibitor , alleviates psoriasis in a xenograft transplantation model .
18311929	0	Decabromobiphenyl	0,17	aryl_hydrocarbon_receptor	42,67	Decabromobiphenyl	aryl hydrocarbon receptor	MESH:C575674	25690(Tax:10116)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Decabromobiphenyl -LRB- PBB-209 -RRB- activates the aryl_hydrocarbon_receptor while decachlorobiphenyl -LRB- PCB-209 -RRB- is inactive : experimental evidence and computational rationalization of the different behavior of some halogenated_biphenyls .
7748810	0	Decapeptyl	10,20	TGF-alpha	80,89	Decapeptyl	TGF-alpha	MESH:D017329	7039	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of Decapeptyl -LRB- a GnRH analogue -RRB- and of transforming_growth_factor-alpha -LRB- TGF-alpha -RRB- , in the presence of heparin , on the sulfatase activity of human breast_cancer cells .
15122921	0	Decavanadate	0,12	myosin	106,112	Decavanadate	myosin	MESH:D014638	79784	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	Decavanadate binding to a high affinity site near the myosin catalytic centre inhibits F-actin-stimulated myosin ATPase activity .
11019816	0	Decavanadate	0,12	ribonuclease_A	35,49	Decavanadate	ribonuclease A	MESH:D014638	282340(Tax:9913)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Decavanadate inhibits catalysis by ribonuclease_A .
26179333	0	Decitabine	11,21	miR-200c	61,69	Decitabine	miR-200c	MESH:C014347	406985	Chemical	Gene	Effects|nmod|START_ENTITY Effects|acl|END_ENTITY	Effects of Decitabine on Invasion and Exosomal Expression of miR-200c and miR-141 in Oxaliplatin-Resistant Colorectal_Cancer_Cells .
26264445	0	Decitabine	0,10	stem_cell_antigen-1	20,39	Decitabine	stem cell antigen-1	MESH:C014347	110454(Tax:10090)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Decitabine enhances stem_cell_antigen-1 expression in cigarette_smoke_extract-induced emphysema in animal model .
16462021	0	Decline	0,7	glucokinase	11,22	Decline	glucokinase	null	24385(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Decline in glucokinase activity in the arcuate nucleus of streptozotocin-induced diabetic rats .
11673829	0	Decline	0,7	maspin	61,67	Decline	maspin	null	5268	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Decline in the expression of the serine proteinase inhibitor maspin is associated with tumour progression in ductal_carcinomas of the breast .
24472739	0	Decorin	0,7	AMPK	18,22	Decorin	AMPK	null	5562	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Decorin activates AMPK , an energy sensor kinase , to induce autophagy in endothelial cells .
26577249	0	Deferoxamine	0,12	LDLR	24,28	Deferoxamine	LDLR	MESH:D003676	3949	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Deferoxamine stimulates LDLR expression and LDL uptake in HepG2 cells .
16837131	0	Deferoxamine	0,12	interferon-gamma	51,67	Deferoxamine	interferon-gamma	MESH:D003676	3458	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|effect effect|nmod|END_ENTITY	Deferoxamine enhances anti-proliferative effect of interferon-gamma against hepatocellular_carcinoma cells .
7660147	0	Defibrotide	0,11	PAI-2	29,34	Defibrotide	PAI-2	MESH:C036901	5055	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|activity activity|amod|END_ENTITY	Defibrotide reduces monocyte PAI-2 and procoagulant activity .
12414641	0	Defibrotide	0,11	granulocyte_colony-stimulating_factor	32,69	Defibrotide	granulocyte colony-stimulating factor	MESH:C036901	1440	Chemical	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	Defibrotide in combination with granulocyte_colony-stimulating_factor significantly enhances the mobilization of primitive and committed peripheral blood progenitor cells in mice .
8052971	0	Defibrotide	0,11	thrombomodulin	37,51	Defibrotide	thrombomodulin	MESH:C036901	7056	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|nmod|END_ENTITY	Defibrotide stimulates expression of thrombomodulin in human endothelial cells .
19012509	0	Deforolimus	0,11	mTOR	30,34	Deforolimus	mTOR	MESH:C515074	21977(Tax:10090)	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Deforolimus -LRB- AP23573 -RRB- a novel mTOR inhibitor in clinical development .
26272616	0	Degenerate	0,10	Leucyl-tRNA_Synthetase	47,69	Degenerate	Leucyl-tRNA Synthetase	null	51520	Chemical	Gene	Domain|compound|START_ENTITY Domain|nmod|END_ENTITY	Degenerate CP1 Domain from Human Mitochondrial Leucyl-tRNA_Synthetase .
17015749	0	Deguelin	0,8	Akt	13,16	Deguelin	Akt	MESH:C107676	207	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Deguelin , an Akt inhibitor , suppresses IkappaBalpha kinase activation leading to suppression of NF-kappaB-regulated gene expression , potentiation of apoptosis , and inhibition of cellular invasion .
22623043	0	Deguelin	0,8	Akt	13,16	Deguelin	Akt	MESH:C107676	11651(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Deguelin , an Akt inhibitor , down-regulates NF-kB signaling and induces apoptosis in colon_cancer cells and inhibits tumor growth in mice .
25741219	0	Deguelin	0,8	Akt	84,87	Deguelin	Akt	MESH:C107676	207	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|regulating regulating|dobj|END_ENTITY	Deguelin induces the apoptosis of lung_cancer cells through regulating a ROS driven Akt pathway .
25674226	0	Dehydroabietic_acid	0,19	FOXO1	61,66	Dehydroabietic acid	FOXO1	MESH:C013913	56458(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|activation activation|nmod|END_ENTITY	Dehydroabietic_acid reverses TNF-a-induced the activation of FOXO1 and suppression of TGF-b1 / Smad signaling in human adult dermal fibroblasts .
25674226	0	Dehydroabietic_acid	0,19	TGF-b1	86,92	Dehydroabietic acid	TGF-b1	MESH:C013913	21803(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|activation activation|nmod|END_ENTITY	Dehydroabietic_acid reverses TNF-a-induced the activation of FOXO1 and suppression of TGF-b1 / Smad signaling in human adult dermal fibroblasts .
10942777	0	Dehydroaltenusin	0,16	DNA_polymerase_alpha	30,50	Dehydroaltenusin	DNA polymerase alpha	MESH:C095645	5422	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Dehydroaltenusin , a mammalian DNA_polymerase_alpha inhibitor .
26356821	0	Dehydroandrographolide	0,22	iNOS	27,31	Dehydroandrographolide	iNOS	MESH:C478098	51477	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Dehydroandrographolide , an iNOS inhibitor , extracted from from Andrographis paniculata -LRB- Burm.f . -RRB-
25066549	0	Dehydrocostuslactone	0,20	hemeoxygenase-1	89,104	Dehydrocostuslactone	hemeoxygenase-1	MESH:C083030	15368(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|induction induction|nmod|END_ENTITY	Dehydrocostuslactone inhibits LPS-induced inflammation by p38MAPK-dependent induction of hemeoxygenase-1 in vitro and improves survival of mice in CLP-induced sepsis in vivo .
15639233	0	Dehydrodiisoeugenol	0,19	nuclear_factor_kappa_B	81,103	Dehydrodiisoeugenol	nuclear factor kappa B	MESH:C496603	18033(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|compound|END_ENTITY	Dehydrodiisoeugenol , an isoeugenol dimer , inhibits lipopolysaccharide-stimulated nuclear_factor_kappa_B activation and cyclooxygenase-2 expression in macrophages .
10077344	0	Dehydroepiandrosterone	0,22	ACTH	47,51	Dehydroepiandrosterone	ACTH	MESH:D003687	5443	Chemical	Gene	response|amod|START_ENTITY END_ENTITY|nsubj|response	Dehydroepiandrosterone -LRB- DHEA -RRB- response to i.v. ACTH in patients with chronic_fatigue_syndrome .
14572450	0	Dehydroepiandrosterone	0,22	BACE	58,62	Dehydroepiandrosterone	BACE	MESH:D003687	23621	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|nmod|END_ENTITY	Dehydroepiandrosterone reduces expression and activity of BACE in NT2 neurons exposed to oxidative stress .
21152205	0	Dehydroepiandrosterone	18,40	BDNF	12,16	Dehydroepiandrosterone	BDNF	MESH:D003687	24225(Tax:10116)	Chemical	Gene	DHEA-Sulfate|appos|START_ENTITY DHEA-Sulfate|appos|END_ENTITY	Monoamines , BDNF , Dehydroepiandrosterone , DHEA-Sulfate , and Childhood Depression-An Animal Model Study .
17591676	0	Dehydroepiandrosterone	0,22	CYP2B6	37,43	Dehydroepiandrosterone	CYP2B6	MESH:D003687	1555	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Dehydroepiandrosterone induces human CYP2B6 through the constitutive_androstane_receptor .
14628495	0	Dehydroepiandrosterone	0,22	DHEA-S	78,84	Dehydroepiandrosterone	DHEA-S	MESH:D003687	6822	Chemical	Gene	replacement|amod|START_ENTITY replacement|nmod|men men|nmod|decline decline|nmod|END_ENTITY	Dehydroepiandrosterone replacement in healthy men with age-related decline of DHEA-S : effects on fat distribution , insulin sensitivity and lipid metabolism .
26758459	0	Dehydroepiandrosterone	0,22	DHEA-S	74,80	Dehydroepiandrosterone	DHEA-S	MESH:D003687	6822	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Dehydroepiandrosterone -LRB- DHEA -RRB- supplementation results in supraphysiologic DHEA-S serum levels and progesterone assay interference that may impact clinical management in IVF .
18718910	0	Dehydroepiandrosterone	0,22	FoxO1	53,58	Dehydroepiandrosterone	FoxO1	MESH:D003687	2308	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Dehydroepiandrosterone stimulates phosphorylation of FoxO1 in vascular endothelial cells via phosphatidylinositol 3-kinase - and protein kinase A-dependent signaling pathways to regulate ET-1 synthesis and secretion .
1833106	0	Dehydroepiandrosterone	0,22	IL2	32,35	Dehydroepiandrosterone	IL2	MESH:D003687	3558	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|compound|END_ENTITY	Dehydroepiandrosterone enhances IL2 production and cytotoxic effector function of human T cells .
7736787	0	Dehydroepiandrosterone	0,22	STD	46,49	Dehydroepiandrosterone	STD	MESH:D003687	7535	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Dehydroepiandrosterone sulfotransferase gene -LRB- STD -RRB- : localization to human chromosome band 19q13 .3 .
17591676	0	Dehydroepiandrosterone	0,22	constitutive_androstane_receptor	56,88	Dehydroepiandrosterone	constitutive androstane receptor	MESH:D003687	9970	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Dehydroepiandrosterone induces human CYP2B6 through the constitutive_androstane_receptor .
16150906	0	Dehydroepiandrosterone	0,22	growth_hormone	38,52	Dehydroepiandrosterone	growth hormone	MESH:D003687	81668(Tax:10116)	Chemical	Gene	restoration|amod|START_ENTITY restoration|nmod|expression expression|amod|END_ENTITY	Dehydroepiandrosterone restoration of growth_hormone gene expression in aging female rats , in vivo and in vitro : evidence for actions via estrogen receptors .
16849414	0	Dehydroepiandrosterone	0,22	growth_hormone	114,128	Dehydroepiandrosterone	growth hormone	MESH:D003687	2688	Chemical	Gene	improves|nsubj|START_ENTITY improves|nmod|patients patients|nmod|replacement replacement|compound|END_ENTITY	Dehydroepiandrosterone improves psychological well-being in male and female_hypopituitary patients on maintenance growth_hormone replacement .
17054472	0	Dehydroepiandrosterone	0,22	growth_hormone	50,64	Dehydroepiandrosterone	growth hormone	MESH:D003687	2688	Chemical	Gene	replacement|amod|START_ENTITY reduces|nsubj|replacement reduces|dobj|requirement requirement|amod|END_ENTITY	Dehydroepiandrosterone -LRB- DHEA -RRB- replacement reduces growth_hormone -LRB- GH -RRB- dose requirement in female_hypopituitary patients on GH replacement .
11888843	0	Dehydroepiandrosterone	0,22	interleukin-6	166,179	Dehydroepiandrosterone	interleukin-6	MESH:D003687	3569	Chemical	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Dehydroepiandrosterone in relation to other adrenal hormones during an acute inflammatory stressful disease state compared with chronic inflammatory disease : role of interleukin-6 and tumour_necrosis_factor .
15547086	0	Dehydroepiandrosterone	0,22	interleukin_10	34,48	Dehydroepiandrosterone	interleukin 10	MESH:D003687	3586	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|synthesis synthesis|amod|END_ENTITY	Dehydroepiandrosterone suppresses interleukin_10 synthesis in women with systemic_lupus_erythematosus .
12488352	0	Dehydroepiandrosterone	0,22	peroxisome_proliferator-activated_receptor_gamma	56,104	Dehydroepiandrosterone	peroxisome proliferator-activated receptor gamma	MESH:D003687	25664(Tax:10116)	Chemical	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|nmod|END_ENTITY	Dehydroepiandrosterone down-regulates the expression of peroxisome_proliferator-activated_receptor_gamma in adipocytes .
8615394	0	Dehydroepiandrosterone	0,22	plasminogen_activator_inhibitor_type_1	38,76	Dehydroepiandrosterone	plasminogen activator inhibitor type 1	MESH:D003687	5054	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	Dehydroepiandrosterone reduces plasma plasminogen_activator_inhibitor_type_1 and tissue_plasminogen_activator antigen in men .
12195234	0	Dehydroepiandrosterone	0,22	prolactin	37,46	Dehydroepiandrosterone	prolactin	MESH:D003687	24683(Tax:10116)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Dehydroepiandrosterone regulation of prolactin gene expression in the anterior pituitary does not depend on galanin induction .
15130511	0	Dehydroepiandrosterone	0,22	resistin	36,44	Dehydroepiandrosterone	resistin	MESH:D003687	246250(Tax:10116)	Chemical	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|compound|END_ENTITY	Dehydroepiandrosterone up-regulates resistin gene expression in white_adipose_tissue .
8137159	0	Dehydroepiandrosterone_sulfate	0,30	CA1	66,69	Dehydroepiandrosterone sulfate	CA1	MESH:D019314	759	Chemical	Gene	alters|nsubj|START_ENTITY alters|nmod|END_ENTITY	Dehydroepiandrosterone_sulfate alters synaptic potentials in area CA1 of the hippocampal slice .
23988737	0	Dehydroepiandrosterone_sulfate	0,30	CREB	76,80	Dehydroepiandrosterone sulfate	CREB	MESH:D019314	1385	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|nmod|END_ENTITY	Dehydroepiandrosterone_sulfate mediates activation of transcription factors CREB and ATF-1 via a Ga11-coupled receptor in the spermatogenic cell line GC-2 .
10079390	0	Dehydroepiandrosterone_sulfate	0,30	DHEAS	32,37	Dehydroepiandrosterone sulfate	DHEAS	MESH:D019314	6822	Chemical	Gene	secretion|amod|START_ENTITY secretion|appos|END_ENTITY	Dehydroepiandrosterone_sulfate -LRB- DHEAS -RRB- secretion in early and advanced solid neoplasms : selective deficiency in metastatic_disease .
16256973	0	Dehydroepiandrosterone_sulfate	0,30	insulin	118,125	Dehydroepiandrosterone sulfate	insulin	MESH:D019314	3630	Chemical	Gene	distribution|amod|START_ENTITY distribution|dep|relationship relationship|nmod|concentrations concentrations|compound|END_ENTITY	Dehydroepiandrosterone_sulfate -LRB- DHEA-S -RRB- distribution in Spanish prepuberal children : relationship with fasting plasma insulin concentrations and insulin resistance .
8938473	0	Dehydroepiandrosterone_sulfate	0,30	interleukin-8	57,70	Dehydroepiandrosterone sulfate	interleukin-8	MESH:D019314	100009129(Tax:9986)	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|effect effect|nmod|END_ENTITY	Dehydroepiandrosterone_sulfate potentiates the effect of interleukin-8 on the cervix .
23001207	0	Dehydroepiandrosterone_sulfate	2,32	osteoprotegerin	34,49	Dehydroepiandrosterone sulfate	osteoprotegerin	MESH:D019314	4982	Chemical	Gene	ligand|advmod|START_ENTITY ligand|nsubj|END_ENTITY	Dehydroepiandrosterone_sulfate , osteoprotegerin and its soluble ligand sRANKL and bone metabolism in girls with anorexia_nervosa .
20172962	0	Dehydroepiandrosterone_sulfate	0,30	protein_kinase_C-beta	50,71	Dehydroepiandrosterone sulfate	protein kinase C-beta	MESH:D019314	5579	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Dehydroepiandrosterone_sulfate directly activates protein_kinase_C-beta to increase human neutrophil superoxide generation .
17082909	0	Dehydroepiandrosterone_sulphate	0,31	IgG	41,44	Dehydroepiandrosterone sulphate	IgG	CHEBI:16814	16059(Tax:10090)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|compound|END_ENTITY	Dehydroepiandrosterone_sulphate enhances IgG and Interferon-gamma production during immunization to tuberculosis in young but not aged mice .
16020669	0	Dehydroxymethylepoxyquinomicin	0,30	nuclear_factor-kappaB	40,61	Dehydroxymethylepoxyquinomicin	nuclear factor-kappaB	MESH:C464444	18033(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Dehydroxymethylepoxyquinomicin , a novel nuclear_factor-kappaB inhibitor , induces apoptosis in multiple_myeloma cells in an IkappaBalpha-independent manner .
25000305	0	Delphinidin	0,11	MMP-9	35,40	Delphinidin	MMP-9	MESH:C017185	4318	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Delphinidin suppresses PMA-induced MMP-9 expression by blocking the NF-kB activation through MAPK signaling pathways in MCF-7 human breast_carcinoma cells .
20801663	0	Delphinidin	0,11	glyoxalase_I	69,81	Delphinidin	glyoxalase I	MESH:C017185	2739	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Delphinidin , a dietary anthocyanidin in berry fruits , inhibits human glyoxalase_I .
25962102	0	Delphinidin_3-Rutinoside	16,40	Glucagon-Like_Peptide-1	52,75	Delphinidin 3-Rutinoside	Glucagon-Like Peptide-1	MESH:C010705	14526(Tax:10090)	Chemical	Gene	Stimulates|nsubj|START_ENTITY Stimulates|dobj|Secretion Secretion|compound|END_ENTITY	The Anthocyanin Delphinidin_3-Rutinoside Stimulates Glucagon-Like_Peptide-1 Secretion in Murine GLUTag Cell Line via the Ca2 + / Calmodulin-Dependent Kinase II Pathway .
2871232	0	Delta-9-tetrahydrocannabinol	0,28	ABP	40,43	Delta-9-tetrahydrocannabinol	ABP	MESH:D013759	65029(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|compound|END_ENTITY	Delta-9-tetrahydrocannabinol stimulates ABP secretion from rat Sertoli cells in vitro .
18789920	0	Delta-9-tetrahydrocannabinol	0,28	c-Fos	58,63	Delta-9-tetrahydrocannabinol	c-Fos	MESH:D013759	314322(Tax:10116)	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|expression expression|amod|END_ENTITY	Delta-9-tetrahydrocannabinol differently affects striatal c-Fos expression following haloperidol or clozapine administration .
25706085	0	Delta-aminolevulinic_acid	0,25	ALA-D	48,53	Delta-aminolevulinic acid	ALA-D	MESH:D000622	210	Chemical	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Delta-aminolevulinic_acid dehydratase activity -LRB- ALA-D -RRB- in red mullet -LRB- Mullus barbatus -RRB- from Mediterranean waters as biomarker of lead exposure .
10029897	0	Delta-aminolevulinic_acid	0,25	ALAD	39,43	Delta-aminolevulinic acid	ALAD	MESH:D000622	210	Chemical	Gene	dehydratase|amod|START_ENTITY dehydratase|appos|END_ENTITY	Delta-aminolevulinic_acid dehydratase -LRB- ALAD -RRB- activity in blood of Bufo arenarum -LRB- Anura -RRB- .
15474621	0	Delta-aminolevulinic_acid	0,25	ALAD	39,43	Delta-aminolevulinic acid	ALAD	MESH:D000622	210	Chemical	Gene	dehydratase|amod|START_ENTITY dehydratase|appos|END_ENTITY	Delta-aminolevulinic_acid dehydratase -LRB- ALAD -RRB- polymorphism and susceptibility of workers exposed to inorganic lead and its effects on neurobehavioral functions .
25460652	0	Delta-aminolevulinic_acid	0,25	ALAD	39,43	Delta-aminolevulinic acid	ALAD	MESH:D000622	210	Chemical	Gene	dehydratase|amod|START_ENTITY dehydratase|appos|END_ENTITY	Delta-aminolevulinic_acid dehydratase -LRB- ALAD -RRB- polymorphism in lead exposed Bangladeshi children and its effect on urinary aminolevulinic_acid -LRB- ALA -RRB- .
25569843	0	Delta-aminolevulinic_acid	0,25	ALAD	41,45	Delta-aminolevulinic acid	ALAD	MESH:D000622	210	Chemical	Gene	dehydratase|amod|START_ENTITY dehydratase|appos|END_ENTITY	Delta-aminolevulinic_acid dehydratase -LRB- ALAD -RRB- activity in four free-living bird species exposed to different levels of lead under natural conditions .
6678320	0	Delta-aminolevulinic_acid	1,26	ALAD	40,44	Delta-aminolevulinic acid	ALAD	MESH:D000622	100356141(Tax:9986)	Chemical	Gene	dehydratase|amod|START_ENTITY dehydratase|appos|END_ENTITY	-LSB- Delta-aminolevulinic_acid dehydratase -LRB- ALAD -RRB- activity in red blood cells in different ages -LRB- 2nd report -RRB- .
2848693	0	Delta-guanidinovaleric_acid	0,27	GABA-receptor	58,71	Delta-guanidinovaleric acid	GABA-receptor	MESH:C053509	11337	Chemical	Gene	START_ENTITY|nmod|antagonist antagonist|amod|END_ENTITY	Delta-guanidinovaleric_acid as an endogenous and specific GABA-receptor antagonist : electroencephalographic study .
15194490	0	Delta12-Prostaglandin_J2	0,24	UCH-L1	58,64	Delta12-Prostaglandin J2	UCH-L1	MESH:C499810	7345	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Delta12-Prostaglandin_J2 inhibits the ubiquitin hydrolase UCH-L1 and elicits ubiquitin-protein aggregation without proteasome inhibition .
15557816	0	Delta12-prostaglandin_J2	110,134	Sox-4	15,20	Delta12-prostaglandin J2	Sox-4	MESH:C499810	6659	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of Sox-4 in the cytochrome_c-dependent AIF-independent apoptotic pathway in HeLa cells induced by Delta12-prostaglandin_J2 .
19406241	0	Delta7-sterol	122,135	Dhcr7	147,152	Delta7-sterol	Dhcr7	null	13360(Tax:10090)	Chemical	Gene	reductase|compound|START_ENTITY reductase|appos|END_ENTITY	Steroid production and excretion by the pregnant mouse , particularly in relation to pregnancies with fetuses deficient in Delta7-sterol reductase -LRB- Dhcr7 -RRB- , the enzyme associated with Smith-Lemli-Opitz_syndrome .
9751146	0	Delta9-tetrahydrocannabinol	0,27	AP-1	56,60	Delta9-tetrahydrocannabinol	AP-1	MESH:D013759	24516(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|activity activity|compound|END_ENTITY	Delta9-tetrahydrocannabinol increases sequence-specific AP-1 DNA-binding activity and Fos-related_antigens in the rat brain .
12791597	0	Delta9-tetrahydrocannabinol	0,27	CB1	48,51	Delta9-tetrahydrocannabinol	CB1	MESH:D013759	1268	Chemical	Gene	acts|nsubj|START_ENTITY acts|nmod|receptors receptors|nummod|END_ENTITY	Delta9-tetrahydrocannabinol selectively acts on CB1 receptors in specific regions of dorsal vagal complex to inhibit emesis in ferrets .
18454173	0	Delta9-tetrahydrocannabinol	52,79	JunD	0,4	Delta9-tetrahydrocannabinol	JunD	MESH:D013759	3727	Chemical	Gene	effect|nmod|START_ENTITY involved|nmod|effect involved|nsubjpass|END_ENTITY	JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast_cancer cells .
10771154	0	Deltamethrin	0,12	P53	43,46	Deltamethrin	P53	MESH:C017180	301300(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Deltamethrin induces altered expression of P53 , Bax and Bcl-2 in rat brain .
19422808	0	Demethoxycurcumin	0,17	Bcl-2	26,31	Demethoxycurcumin	Bcl-2	MESH:C050229	596	Chemical	Gene	induces|nsubj|START_ENTITY induces|ccomp|mediated mediated|nsubj|END_ENTITY	Demethoxycurcumin induces Bcl-2 mediated G2/M arrest and apoptosis in human glioma U87 cells .
25052989	0	Denbinobin	0,10	miR-146a	23,31	Denbinobin	miR-146a	MESH:C436544	406938	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Denbinobin upregulates miR-146a expression and attenuates IL-1b-induced upregulation of ICAM-1 and VCAM-1 expressions in osteoarthritis fibroblast-like synoviocytes .
25950728	0	Dendritic_Spines	76,92	fmr1	96,100	Dendritic Spines	fmr1	null	14265(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|Mice Mice|amod|END_ENTITY	Deficit in Motor Training-Induced Clustering , but Not Stabilization , of New Dendritic_Spines in fmr1 Knock-Out Mice .
16026582	0	DeoxyArbutin	0,12	tyrosinase	33,43	DeoxyArbutin	tyrosinase	MESH:C504954	7299	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	DeoxyArbutin : a novel reversible tyrosinase inhibitor with effective in vivo skin lightening potency .
23134995	0	DeoxyArbutin	0,12	tyrosinase	41,51	DeoxyArbutin	tyrosinase	MESH:C504954	7299	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|activity activity|amod|END_ENTITY	DeoxyArbutin and its derivatives inhibit tyrosinase activity and melanin synthesis without inducing reactive_oxygen_species or apoptosis .
12925308	0	Deoxycholate	0,12	BRCA-1	77,83	Deoxycholate	BRCA-1	MESH:D003840	672	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|compound|END_ENTITY	Deoxycholate , an endogenous_tumor promoter and DNA damaging agent , modulates BRCA-1 expression in apoptosis-sensitive epithelial cells : loss of BRCA-1 expression in colonic_adenocarcinomas .
19534809	0	Deoxycholate	0,12	COX-2	21,26	Deoxycholate	COX-2	MESH:D003840	4513	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Deoxycholate induces COX-2 expression via Erk1/2 - , p38-MAPK and AP-1-dependent mechanisms in esophageal_cancer cells .
19534809	0	Deoxycholate	0,12	Erk1/2	42,48	Deoxycholate	Erk1/2	MESH:D003840	5595;5594	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Deoxycholate induces COX-2 expression via Erk1/2 - , p38-MAPK and AP-1-dependent mechanisms in esophageal_cancer cells .
15004225	0	Deoxycholic_acid	0,16	beta-catenin	27,39	Deoxycholic acid	beta-catenin	MESH:D003840	1499	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Deoxycholic_acid activates beta-catenin signaling pathway and increases colon_cell_cancer growth and invasiveness .
11553704	0	Deoxycholic_acid	0,16	epidermal_growth_factor_receptor	63,95	Deoxycholic acid	epidermal growth factor receptor	MESH:D003840	1956	Chemical	Gene	causes|nsubj|START_ENTITY causes|dobj|activation activation|nmod|END_ENTITY	Deoxycholic_acid -LRB- DCA -RRB- causes ligand-independent activation of epidermal_growth_factor_receptor -LRB- EGFR -RRB- and FAS receptor in primary hepatocytes : inhibition of EGFR/mitogen-activated protein kinase-signaling module enhances DCA-induced apoptosis .
11375905	0	Deoxycholic_acid	0,16	p53	28,31	Deoxycholic acid	p53	MESH:D003840	7157	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	Deoxycholic_acid suppresses p53 by stimulating proteasome-mediated p53 protein degradation .
11375905	0	Deoxycholic_acid	0,16	p53	67,70	Deoxycholic acid	p53	MESH:D003840	7157	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|advcl|stimulating stimulating|dobj|degradation degradation|compound|END_ENTITY	Deoxycholic_acid suppresses p53 by stimulating proteasome-mediated p53 protein degradation .
25434397	0	Deoxycholic_acid	0,16	p53	78,81	Deoxycholic acid	p53	MESH:D003840	7157	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|growth growth|nmod|cells cells|nmod|END_ENTITY	Deoxycholic_acid inhibits the growth of BGC-823 gastric_carcinoma cells via a p53 - mediated pathway .
26082486	0	Deoxyhypusine	0,13	eIF5A	30,35	Deoxyhypusine	eIF5A	CHEBI:50038	1984	Chemical	Gene	modification|amod|START_ENTITY modification|nmod|END_ENTITY	Deoxyhypusine modification of eIF5A is essential for Trypanosoma_brucei growth and for expression of polyprolyl-containing proteins .
20045926	0	Deoxypodophyllotoxin	0,20	intercellular_adhesion_molecule-1	48,81	Deoxypodophyllotoxin	intercellular adhesion molecule-1	MESH:C014451	15894(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Deoxypodophyllotoxin inhibits the expression of intercellular_adhesion_molecule-1 induced by tumor_necrosis_factor-alpha in murine lung epithelial cells .
4914081	0	Deoxyribonucleic_acid	0,21	lon	55,58	Deoxyribonucleic acid	lon	CHEBI:16991	20466934	Chemical	Gene	synthesis|amod|START_ENTITY synthesis|nmod|END_ENTITY	Deoxyribonucleic_acid synthesis and cell division in a lon - mutant of Escherichia_coli .
20664957	0	Deoxyschisandrin	0,16	nuclear_factor-kappaB	99,120	Deoxyschisandrin	nuclear factor-kappaB	MESH:C034734	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Deoxyschisandrin inhibits H2O2-induced apoptotic cell death in intestinal epithelial cells through nuclear_factor-kappaB .
23737816	0	Deoxyshikonin	112,125	HIF-1a	65,71	Deoxyshikonin	HIF-1a	MESH:C056013	3091	Chemical	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	Enhancement of Lymphangiogenesis In Vitro via the Regulations of HIF-1a Expression and Nuclear Translocation by Deoxyshikonin .
10952785	0	Deoxyuridine	0,12	dUTPase	29,36	Deoxyuridine	dUTPase	MESH:D003857	34529(Tax:7227)	Chemical	Gene	triphosphatase|nsubj|START_ENTITY triphosphatase|parataxis|END_ENTITY	Deoxyuridine triphosphatase -LRB- dUTPase -RRB- expression and sensitivity to the thymidylate_synthase -LRB- TS -RRB- inhibitor ZD9331 .
1658311	0	Deprenyl	0,8	MAO-B	35,40	Deprenyl	MAO-B	MESH:D012642	4129	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Deprenyl -LRB- selegiline -RRB- , a selective MAO-B inhibitor with active metabolites ; effects on locomotor activity , dopaminergic neurotransmission and firing rate of nigral dopamine neurons .
96466	0	Deprenyl	0,8	monoamine_oxidase_B	44,63	Deprenyl	monoamine oxidase B	MESH:D012642	4129	Chemical	Gene	administration|amod|START_ENTITY administration|dep|inhibitor inhibitor|compound|END_ENTITY	Deprenyl administration in man : a selective monoamine_oxidase_B inhibitor without the ` cheese effect ' .
9551765	0	Deramciclane	0,12	serotonin_5-HT2C_receptor	47,72	Deramciclane	serotonin 5-HT2C receptor	MESH:C060555	3358	Chemical	Gene	agonist|nsubj|START_ENTITY agonist|amod|END_ENTITY	Deramciclane , a putative anxiolytic drug , is a serotonin_5-HT2C_receptor inverse agonist but fails to induce 5-HT2C receptor down-regulation .
21833458	0	Dermatan_sulfate	0,16	monocyte_chemoattractant_protein_1	25,59	Dermatan sulfate	monocyte chemoattractant protein 1	MESH:D003871	20296(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	Dermatan_sulfate reduces monocyte_chemoattractant_protein_1 and TGF-b production , as well as macrophage recruitment and myofibroblast accumulation in mice with unilateral ureteral_obstruction .
8091383	0	Dermatan_sulfate	0,16	thrombin	58,66	Dermatan sulfate	thrombin	MESH:D003871	2147	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Dermatan_sulfate is a more potent inhibitor of clot-bound thrombin than unfractionated and low molecular weight heparins .
6504268	0	Dermorphin	0,10	prolactin	22,31	Dermorphin	prolactin	MESH:C030058	24683(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|compound|END_ENTITY	Dermorphin stimulates prolactin secretion in the rat .
7176064	0	Desaminocysteine-D-arginine	0,27	vasopressin	28,39	Desaminocysteine-D-arginine	vasopressin	null	551	Chemical	Gene	test|amod|START_ENTITY test|compound|END_ENTITY	Desaminocysteine-D-arginine vasopressin test inthe evaluation and postoperative followup of obstructed kidneys in infancy and childhood .
3005409	0	Desferoxamine	0,13	IL_2	21,25	Desferoxamine	IL 2	null	3558	Chemical	Gene	blocks|nsubj|START_ENTITY blocks|dobj|expression expression|compound|END_ENTITY	Desferoxamine blocks IL_2 receptor expression on human T lymphocytes .
25075254	0	Desferrioxamine	0,15	HIF-1_alpha	26,37	Desferrioxamine	HIF-1 alpha	MESH:D003676	29560(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Desferrioxamine regulates HIF-1_alpha expression in neonatal rat brain after hypoxia-ischemia .
11239825	0	Desferrioxamine	0,15	cyclooxygenase-2	47,63	Desferrioxamine	cyclooxygenase-2	MESH:D003676	5743	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Desferrioxamine , an iron chelator , upregulates cyclooxygenase-2 expression and prostaglandin production in a human macrophage cell line .
16527254	0	Desferrioxamine	0,15	cyclooxygenase-2	72,88	Desferrioxamine	cyclooxygenase-2	MESH:D003676	5743	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|accumulation accumulation|nmod|pathway pathway|amod|END_ENTITY	Desferrioxamine , an iron chelator , enhances HIF-1alpha accumulation via cyclooxygenase-2 signaling pathway .
1857480	0	Desferrioxamine	0,15	erythropoietin	54,68	Desferrioxamine	erythropoietin	MESH:D003676	2056	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Desferrioxamine enhances the haemopoietic response to erythropoietin , but adverse events are common .
8260699	0	Desferrioxamine	0,15	erythropoietin	24,38	Desferrioxamine	erythropoietin	MESH:D003676	2056	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible_factor_1 DNA-binding activity : implications for models of hypoxia signal transduction .
15962935	0	Desferrioxamine	0,15	myoglobin	78,87	Desferrioxamine	myoglobin	MESH:D003676	4151	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Desferrioxamine inhibits production of cytotoxic heme to protein cross-linked myoglobin : a mechanism to protect against oxidative stress without iron chelation .
19921381	0	Desflurane	0,10	transient_receptor_potential_A1	59,90	Desflurane	transient receptor potential A1	MESH:C053562	8989	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Desflurane induces airway contraction mainly by activating transient_receptor_potential_A1 of sensory C-fibers .
17510525	0	Desipramine	0,11	Bcl-2	22,27	Desipramine	Bcl-2	MESH:D003891	24224(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Desipramine activated Bcl-2 expression and inhibited lipopolysaccharide-induced apoptosis in hippocampus-derived adult neural stem cells .
2667015	0	Desipramine	0,11	growth_hormone	34,48	Desipramine	growth hormone	MESH:D003891	2688	Chemical	Gene	increases|nsubj|START_ENTITY increases|xcomp|circulating circulating|dobj|END_ENTITY	Desipramine increases circulating growth_hormone in elderly depressed patients : a pilot study .
19818834	0	Desipramine	0,11	norepinephrine_transporter	35,61	Desipramine	norepinephrine transporter	MESH:D003891	83511(Tax:10116)	Chemical	Gene	induced|nsubj|START_ENTITY induced|nmod|END_ENTITY	Desipramine induced changes in the norepinephrine_transporter , alpha - and gamma-synuclein in the hippocampus , amygdala and striatum .
26135009	0	Desloratadine	162,175	UGT2B10	202,209	Desloratadine	UGT2B10	MESH:C121345	7365	Chemical	Gene	START_ENTITY|nmod|Inhibitor Inhibitor|compound|END_ENTITY	Further Characterization of the Metabolism of Desloratadine and its Cytochrome_P450 and UDP-Glucuronosyltransferase -LRB- UGT -RRB- Inhibition Potential : Identification of Desloratadine as a Relatively Selective UGT2B10 Inhibitor .
26455479	0	Desloratadine	0,13	histamine_H1_receptor	51,72	Desloratadine	histamine H1 receptor	MESH:C121345	100135539(Tax:10141)	Chemical	Gene	injection|amod|START_ENTITY injection|appos|antagonist antagonist|amod|END_ENTITY	Desloratadine citrate disodium injection , a potent histamine_H1_receptor antagonist , inhibits chemokine production in ovalbumin-induced allergic_rhinitis guinea_pig model and histamine-induced human nasal epithelial cells via inhibiting the ERK1/2 and NF-kappa_B signal cascades .
9243353	0	Desmethylselegiline	0,19	monoamine_oxidase_type_B	81,105	Desmethylselegiline	monoamine oxidase type B	MESH:C017861	4129	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Desmethylselegiline , a metabolite of selegiline , is an irreversible inhibitor of monoamine_oxidase_type_B in humans .
7545469	0	Desmopressin	0,12	P-selectin	33,43	Desmopressin	P-selectin	MESH:D003894	6403	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Desmopressin induces endothelial P-selectin expression and leukocyte rolling in postcapillary venules .
7561450	0	Desmopressin	0,12	P-selectin	42,52	Desmopressin	P-selectin	MESH:D003894	6403	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|nmod|END_ENTITY	Desmopressin stimulates the expression of P-selectin on human platelets in vitro .
19064279	0	Desmopressin	0,12	VWF	150,153	Desmopressin	VWF	MESH:D003894	7450	Chemical	Gene	therapy|compound|START_ENTITY therapy|dep|END_ENTITY	Desmopressin therapy to assist the functional identification and characterisation of von_Willebrand disease : differential utility from combining two -LRB- VWF : CB and VWF : RCo -RRB- von_Willebrand factor activity assays ?
15056873	0	Destruxin_E	0,11	cyclin_D1	53,62	Destruxin E	cyclin D1	MESH:C040425	595	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|levels levels|amod|END_ENTITY	Destruxin_E , a cyclodepsipeptide antibiotic , reduces cyclin_D1 levels and inhibits anchorage-independent growth of v-Ki-ras-expressed pMAM-ras-REF cells .
21785598	0	Determine	35,44	Snf2-Related_CBP_Activator_Protein	73,107	Determine	Snf2-Related CBP Activator Protein	null	10847;6597	Chemical	Gene	Activity|compound|START_ENTITY Activity|nmod|END_ENTITY	Loss of H2A.Z Is Not Sufficient to Determine Transcriptional Activity of Snf2-Related_CBP_Activator_Protein or p400 Complexes .
10912661	11	Devazepide	1354,1364	CCK	1384,1387	Devazepide	CCK	MESH:D020109	25298(Tax:10116)	Chemical	Gene	affect|nsubj|START_ENTITY affect|dobj|level level|compound|END_ENTITY	Devazepide did not affect the CCK level but decreased the pancreatic weight by 24 % compared with BSA-infused rats .
19407653	0	Devazepide	0,10	CCK	39,42	Devazepide	CCK	MESH:D020109	885	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|nmod|receptors receptors|compound|END_ENTITY	Devazepide , a nonpeptide antagonist of CCK receptors , induces apoptosis and inhibits Ewing_tumor growth .
9476995	0	Devazepide	0,10	CCK	14,17	Devazepide	CCK	MESH:D020109	25298(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Devazepide , a CCK -LRB- A -RRB- antagonist , attenuates the satiating but not the preference conditioning effects of intestinal carbohydrate infusions in rats .
24336651	9	Dex	1338,1341	miR-23a	1367,1374	Dex	miR-23a	D003907	387216(Tax:10090)	Chemical	Gene	suppress|nsubj|START_ENTITY suppress|xcomp|END_ENTITY	Dex did not further suppress miR-23a in myotubes from Cn-deficient mice .
9210472	0	Dexamethasone	0,13	5-lipoxygenase	38,52	Dexamethasone	5-lipoxygenase	MESH:D003907	240	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Dexamethasone increases expression of 5-lipoxygenase and its activating protein in human monocytes and THP-1 cells .
18692485	0	Dexamethasone	0,13	ABCG2	29,34	Dexamethasone	ABCG2	MESH:D003907	9429	Chemical	Gene	START_ENTITY|dobj|levels levels|compound|END_ENTITY	Dexamethasone down-regulates ABCG2 expression levels in breast_cancer cells .
2545993	0	Dexamethasone	0,13	ACTH	25,29	Dexamethasone	ACTH	MESH:D003907	5443	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|release release|amod|END_ENTITY	Dexamethasone suppresses ACTH release without attenuating pituitary cyclic_AMP response to stress in vivo .
6280027	5	Dexamethasone	725,738	ACTH	782,786	Dexamethasone	ACTH	MESH:D003907	5443	Chemical	Gene	blocks|nsubj|START_ENTITY blocks|advcl|decreasing decreasing|dobj|END_ENTITY	Dexamethasone blocks this periodicity without decreasing ACTH significantly .
14736953	0	Dexamethasone	0,13	AP-1	24,28	Dexamethasone	AP-1	MESH:D003907	3726	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	Dexamethasone regulates AP-1 to repress TNF-alpha induced MCP-1 production in human glomerular endothelial cells .
18316202	0	Dexamethasone	0,13	BAFF	23,27	Dexamethasone	BAFF	MESH:D003907	10673	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Dexamethasone inhibits BAFF expression in fibroblast-like synoviocytes from patients with rheumatoid_arthritis .
19911699	0	Dexamethasone	0,13	BCRP	28,32	Dexamethasone	BCRP	MESH:D003907	9429	Chemical	Gene	downregulates|amod|START_ENTITY END_ENTITY|nsubj|downregulates	Dexamethasone downregulates BCRP mRNA and protein expression in breast_cancer cell lines .
19995710	0	Dexamethasone	0,13	Bax	25,28	Dexamethasone	Bax	MESH:D003907	12028(Tax:10090)	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|expression expression|compound|END_ENTITY	Dexamethasone effects on Bax expression in the mouse testicular germ cells .
16699951	0	Dexamethasone	0,13	Bcl-XL	84,90	Dexamethasone	Bcl-XL	MESH:D003907	598	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|expression expression|nmod|END_ENTITY	Dexamethasone inhibits apoptosis in C6 glioma cells through increased expression of Bcl-XL .
17116261	0	Dexamethasone	0,13	C-type_Natriuretic_Peptide	39,65	Dexamethasone	C-type Natriuretic Peptide	MESH:D003907	4880	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|nmod|END_ENTITY	Dexamethasone stimulates expression of C-type_Natriuretic_Peptide in chondrocytes .
18472871	0	Dexamethasone	0,13	CD11b	45,50	Dexamethasone	CD11b	MESH:D003907	3684	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|levels levels|nmod|END_ENTITY	Dexamethasone reduces cell surface levels of CD11b on human eosinophils .
9172010	0	Dexamethasone	0,13	CD2	24,27	Dexamethasone	CD2	MESH:D003907	914	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|compound|END_ENTITY	Dexamethasone modulates CD2 expression .
11679924	0	Dexamethasone	0,13	CD4	23,26	Dexamethasone	CD4	MESH:D003907	920	Chemical	Gene	deletion|compound|START_ENTITY deletion|compound|END_ENTITY	Dexamethasone inhibits CD4 T cell deletion mediated by macrophages from human_immunodeficiency_virus-infected persons .
23272037	0	Dexamethasone	0,13	CFTR	24,28	Dexamethasone	CFTR	MESH:D003907	1080	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Dexamethasone regulates CFTR expression in Calu-3 cells with the involvement of chaperones HSP70 and HSP90 .
23671328	0	Dexamethasone	0,13	CRH	86,89	Dexamethasone	CRH	MESH:D003907	1392	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|complex complex|nmod|promoter promoter|compound|END_ENTITY	Dexamethasone induces a putative repressor complex and chromatin modifications in the CRH promoter .
10526580	0	Dexamethasone	0,13	CTLA-4	23,29	Dexamethasone	CTLA-4	MESH:D003907	12477(Tax:10090)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	Dexamethasone enhances CTLA-4 expression during T cell activation .
15467356	0	Dexamethasone	0,13	CXCR4	47,52	Dexamethasone	CXCR4	MESH:D003907	60628(Tax:10116)	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	Dexamethasone downregulates chemokine receptor CXCR4 and exerts neuroprotection against hypoxia/ischemia-induced brain_injury in neonatal rats .
8643461	0	Dexamethasone	0,13	CYP3A	65,70	Dexamethasone	CYP3A	MESH:D003907	1576	Chemical	Gene	responsiveness|amod|START_ENTITY responsiveness|nmod|gene gene|compound|END_ENTITY	Dexamethasone responsiveness of a major glucocorticoid-inducible CYP3A gene is mediated by elements unrelated to a glucocorticoid_receptor binding motif .
15608142	0	Dexamethasone	0,13	Dok-1	58,63	Dexamethasone	Dok-1	MESH:D003907	312477(Tax:10116)	Chemical	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|END_ENTITY	Dexamethasone up-regulates the inhibitory adaptor protein Dok-1 and suppresses downstream activation of the mitogen-activated protein kinase pathway in antigen-stimulated RBL-2H3 mast cells .
20667622	0	Dexamethasone	0,13	FOXP3	26,31	Dexamethasone	FOXP3	MESH:D003907	50943	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	Dexamethasone upregulates FOXP3 expression without increasing regulatory activity .
9645706	0	Dexamethasone	0,13	GH	38,40	Dexamethasone	GH	MESH:D003907	81668(Tax:10116)	Chemical	Gene	growth_hormone|amod|START_ENTITY growth_hormone|appos|END_ENTITY	Dexamethasone impairs growth_hormone -LRB- GH -RRB- - stimulated growth by suppression of local insulin-like_growth_factor _ -LRB- IGF -RRB- - I production and expression of GH - and IGF-I-receptor in cultured rat chondrocytes .
9013557	0	Dexamethasone	0,13	GLUT2	55,60	Dexamethasone	GLUT2	MESH:D003907	25351(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|degradation degradation|nmod|END_ENTITY	Dexamethasone induces posttranslational degradation of GLUT2 and inhibition of insulin secretion in isolated pancreatic beta cells .
8863182	0	Dexamethasone	0,13	GLUT_1	108,114	Dexamethasone	GLUT 1	MESH:D003907	24778(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	Dexamethasone modulates insulin_receptor expression and subcellular distribution of the glucose transporter GLUT_1 in UMR 106-01 , a clonal osteogenic_sarcoma cell line .
21822780	0	Dexamethasone	0,13	ICAM-1	23,29	Dexamethasone	ICAM-1	MESH:D003907	25464(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Dexamethasone inhibits ICAM-1 and MMP-9 expression and reduces brain_edema in intracerebral_hemorrhagic rats .
9374718	0	Dexamethasone	0,13	IFN-gamma	65,74	Dexamethasone	IFN-gamma	MESH:D003907	3458	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|apoptosis apoptosis|acl|induced induced|nmod|END_ENTITY	Dexamethasone inhibits lung epithelial cell apoptosis induced by IFN-gamma and Fas .
9679857	0	Dexamethasone	0,13	IL-13	59,64	Dexamethasone	IL-13	MESH:D003907	3596	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|nmod|END_ENTITY	Dexamethasone suppresses gene expression and production of IL-13 by human mast cell line and lung mast cells .
23904364	0	Dexamethasone	0,13	IL-17	22,27	Dexamethasone	IL-17	MESH:D003907	16171(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|amod|END_ENTITY	Dexamethasone reduces IL-17 and Tim-3 expression in BALF of asthmatic mice .
10936515	0	Dexamethasone	0,13	IL-1_beta	23,32	Dexamethasone	IL-1 beta	MESH:D003907	16176(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Dexamethasone inhibits IL-1_beta gene expression in LPS-stimulated RAW 264.7 cells by blocking NF-kappa_B / Rel and AP-1 activation .
7922784	0	Dexamethasone	0,13	IL-1_beta	24,33	Dexamethasone	IL-1 beta	MESH:D003907	3553	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|amod|END_ENTITY	Dexamethasone regulates IL-1_beta and TNF-alpha-induced interleukin-8 production in human bone marrow stromal and osteoblast-like cells .
1991962	0	Dexamethasone	0,13	IL-1_or_tumor_necrosis_factor	93,122	Dexamethasone	IL-1 or tumor necrosis factor	MESH:D003907	3552;7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Dexamethasone inhibits the induction of monocyte chemotactic-activating factor production by IL-1_or_tumor_necrosis_factor .
9218566	0	Dexamethasone	0,13	IL-1beta	54,62	Dexamethasone	IL-1beta	MESH:D003907	3553	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	Dexamethasone potently enhances phorbol_ester-induced IL-1beta gene expression and nuclear factor NF-kappaB activation .
15527103	0	Dexamethasone	0,13	IL-2	43,47	Dexamethasone	IL-2	MESH:D003907	16183(Tax:10090)	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Dexamethasone mediated inhibition of local IL-2 immunotherapy is dose dependent in experimental brain_tumors .
26670431	0	Dexamethasone	0,13	IL-29	24,29	Dexamethasone	IL-29	MESH:D003907	282618	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|compound|END_ENTITY	Dexamethasone decreases IL-29 expression in house_dust_mite-stimulated human bronchial epithelial cells .
9734662	0	Dexamethasone	0,13	IL-6	38,42	Dexamethasone	IL-6	MESH:D003907	3569	Chemical	Gene	decrease|nsubj|START_ENTITY decrease|dobj|receptor receptor|compound|END_ENTITY	Dexamethasone plus retinoids decrease IL-6 / IL-6 receptor and induce apoptosis in myeloma cells .
9734662	0	Dexamethasone	0,13	IL-6	43,47	Dexamethasone	IL-6	MESH:D003907	3569	Chemical	Gene	decrease|nsubj|START_ENTITY decrease|dobj|receptor receptor|compound|END_ENTITY	Dexamethasone plus retinoids decrease IL-6 / IL-6 receptor and induce apoptosis in myeloma cells .
15840176	0	Dexamethasone	0,13	IL-9	23,27	Dexamethasone	IL-9	MESH:D003907	3578	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	Dexamethasone inhibits IL-9 production by human T cells .
26956216	0	Dexamethasone	0,13	Interleukin-1a	95,109	Dexamethasone	Interleukin-1a	MESH:D003907	3552	Chemical	Gene	Release|compound|START_ENTITY Release|nmod|END_ENTITY	Dexamethasone Release from Within Engineered Cartilage as a Chondroprotective Strategy Against Interleukin-1a .
8938730	0	Dexamethasone	0,13	Kv1	36,39	Dexamethasone	Kv1	MESH:D003907	25470(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|expression expression|amod|END_ENTITY	Dexamethasone and stress upregulate Kv1 .5 K + channel gene expression in rat ventricular myocytes .
12967943	0	Dexamethasone	0,13	L-selectin	64,74	Dexamethasone	L-selectin	MESH:D003907	6402	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Dexamethasone enhances interaction of endogenous annexin_1 with L-selectin and triggers shedding of L-selectin in the monocytic cell line U-937 .
9390113	0	Dexamethasone	0,13	L-selectin	47,57	Dexamethasone	L-selectin	MESH:D003907	6402	Chemical	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|nmod|END_ENTITY	Dexamethasone down-regulates the expression of L-selectin on the surface of neutrophils and lymphocytes in humans .
24064060	0	Dexamethasone	0,13	LRRK2	40,45	Dexamethasone	LRRK2	MESH:D003907	120892	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Dexamethasone induces the expression of LRRK2 and a-synuclein , two genes that when mutated cause Parkinson 's _ disease in an autosomal dominant manner .
26525635	0	Dexamethasone	0,13	MUC5AC	28,34	Dexamethasone	MUC5AC	MESH:D003907	4586	Chemical	Gene	modulation|amod|START_ENTITY modulation|nmod|expression expression|compound|END_ENTITY	Dexamethasone modulation of MUC5AC and MUC2 gene expression in a generalized model of middle_ear_inflammation .
25830874	0	Dexamethasone	0,13	Myelin_Protein_Zero	76,95	Dexamethasone	Myelin Protein Zero	MESH:D003907	17528(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|Expression Expression|nmod|END_ENTITY	Dexamethasone Regulates Cochlear Expression of Deafness-associated Proteins Myelin_Protein_Zero and Heat_Shock_Protein_70 , as Revealed by iTRAQ Proteomics .
15755560	0	Dexamethasone	0,13	NT-3	23,27	Dexamethasone	NT-3	MESH:D003907	81737(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	Dexamethasone enhances NT-3 expression in rat hippocampus after traumatic_brain_injury .
21928335	0	Dexamethasone	0,13	Ndrg2	33,38	Dexamethasone	Ndrg2	MESH:D003907	171114(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Dexamethasone indirectly induces Ndrg2 expression in rat astrocytes .
25171190	0	Dexamethasone	0,13	Nox1	26,30	Dexamethasone	Nox1	MESH:D003907	114243(Tax:10116)	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Dexamethasone upregulates Nox1 expression in vascular smooth muscle cells .
16641216	0	Dexamethasone	0,13	Nuclear_Factor-kappaB	39,60	Dexamethasone	Nuclear Factor-kappaB	MESH:D003907	18033(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|nmod|END_ENTITY	Dexamethasone suppresses expression of Nuclear_Factor-kappaB in the cells of tracheobronchial lavage fluid in premature neonates with respiratory distress .
10537053	0	Dexamethasone	0,13	P-glycoprotein	28,42	Dexamethasone	P-glycoprotein	MESH:D003907	287115(Tax:10116)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|activity activity|amod|END_ENTITY	Dexamethasone regulation of P-glycoprotein activity in an immortalized rat brain endothelial cell line , GPNT .
19379318	0	Dexamethasone	0,13	P-glycoprotein	110,124	Dexamethasone	P-glycoprotein	MESH:D003907	5243	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|expression expression|amod|END_ENTITY	Dexamethasone treatment of a canine , but not human , tumour cell line increases chemoresistance independent of P-glycoprotein and multidrug resistance-related protein expression .
25882702	0	Dexamethasone	8,21	Progesterone_Receptor	78,99	Dexamethasone	Progesterone Receptor	MESH:D003907	18667(Tax:10090)	Chemical	Gene	Inhibition|compound|START_ENTITY Inhibition|nmod|END_ENTITY	Maximal Dexamethasone Inhibition of Luminal Epithelial Proliferation Involves Progesterone_Receptor -LRB- PR -RRB- - and Non-PR-Mediated Mechanisms in Neonatal Mouse Uterus .
17157265	0	Dexamethasone	0,13	SGK1	82,86	Dexamethasone	SGK1	MESH:D003907	20393(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|nmod|END_ENTITY	Dexamethasone increases Na + / K + ATPase activity in insulin secreting cells through SGK1 .
26094588	0	Dexamethasone	0,13	SLC7A5	28,34	Dexamethasone	SLC7A5	MESH:D003907	8140	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Dexamethasone Downregulates SLC7A5 Expression and Promotes Cell Cycle Arrest , Autophagy and Apoptosis in BeWo Cells .
25356121	0	Dexamethasone	0,13	TGF-b	73,78	Dexamethasone	TGF-b	MESH:D003907	21803(Tax:10090)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|nmod|END_ENTITY	Dexamethasone attenuates bleomycin-induced lung fibrosis in mice through TGF-b , Smad3 and JAK-STAT pathway .
10233182	0	Dexamethasone	0,13	TGF-beta1	116,125	Dexamethasone	TGF-beta1	MESH:D003907	59086(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|cells cells|nmod|pathway pathway|amod|END_ENTITY	Dexamethasone inhibits IFNgamma-induced MHC class II expression of intestinal epithelial cells independently of the TGF-beta1 regulatory pathway .
1880152	5	Dexamethasone	1026,1039	TGF-beta_1	1097,1107	Dexamethasone	TGF-beta 1	MESH:D003907	59086(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|nmod|END_ENTITY	Dexamethasone -LRB- Dex -RRB- , on the other hand , inhibits the secretion of both TGF-beta_1 and TGF-beta_2 in A549 cells , while selectively inhibiting TGF-beta_1 secretion in NRK-49F cells .
17317742	0	Dexamethasone	0,13	TIMP-1	68,74	Dexamethasone	TIMP-1	MESH:D003907	7076	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Dexamethasone induces the expression of metalloproteinase inhibitor TIMP-1 in the murine cerebral vascular endothelial cell line cEND .
11161842	0	Dexamethasone	0,13	TNF-alpha	21,30	Dexamethasone	TNF-alpha	MESH:D003907	21926(Tax:10090)	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|expression expression|amod|END_ENTITY	Dexamethasone alters TNF-alpha expression in retinopathy .
14512725	0	Dexamethasone	0,13	TNF-alpha	23,32	Dexamethasone	TNF-alpha	MESH:D003907	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|synthesis synthesis|amod|END_ENTITY	Dexamethasone inhibits TNF-alpha synthesis more effectively in Alzheimer 's _ disease patients than in healthy individuals .
8774068	0	Dexamethasone	0,13	TNF_alpha	71,80	Dexamethasone	TNF alpha	MESH:D003907	24835(Tax:10116)	Chemical	Gene	attenuates_hypoglycemia|amod|START_ENTITY treated|nsubj|attenuates_hypoglycemia treated|nmod|END_ENTITY	Dexamethasone attenuates_hypoglycemia in ten day old rats treated with TNF_alpha .
24350219	0	Dexamethasone	0,13	Triggering_Receptor_Expressed_on_Myeloid_Cells-1	43,91	Dexamethasone	Triggering Receptor Expressed on Myeloid Cells-1	MESH:D003907	54210	Chemical	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	Dexamethasone Down-Regulates Expression of Triggering_Receptor_Expressed_on_Myeloid_Cells-1 : Evidence for a TNFa-Related Effect .
10739632	0	Dexamethasone	0,13	TrkA	22,26	Dexamethasone	TrkA	MESH:D003907	59109(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Dexamethasone induces TrkA and p75NTR immunoreactivity in the cerebral cortex and hippocampus .
16575391	0	Dexamethasone	0,13	VEGF	78,82	Dexamethasone	VEGF	MESH:D003907	7422	Chemical	Gene	START_ENTITY|nmod|suppression suppression|nmod|expression expression|amod|END_ENTITY	Dexamethasone induction of keloid regression through effective suppression of VEGF expression and keloid fibroblast proliferation .
20204302	0	Dexamethasone	0,13	VEGF	33,37	Dexamethasone	VEGF	MESH:D003907	7422	Chemical	Gene	treatment|amod|START_ENTITY inhibits|nsubj|treatment inhibits|dobj|production production|amod|END_ENTITY	Dexamethasone treatment inhibits VEGF production via suppression of STAT3 in a head_and_neck_cancer cell line .
23426970	0	Dexamethasone	0,13	VEGF	105,109	Dexamethasone	VEGF	MESH:D003907	7422	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Dexamethasone induces caveolin-1 in vascular endothelial cells : implications for attenuated responses to VEGF .
23451215	0	Dexamethasone	0,13	VEGF	25,29	Dexamethasone	VEGF	MESH:D003907	22339(Tax:10090)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|compound|END_ENTITY	Dexamethasone attenuates VEGF expression and inflammation but not barrier dysfunction in a murine model of ventilator-induced lung_injury .
4048265	0	Dexamethasone	0,13	aid	37,40	Dexamethasone	aid	MESH:D003907	57379	Chemical	Gene	suppression|compound|START_ENTITY test|nsubj|suppression test|nmod|END_ENTITY	Dexamethasone suppression test as an aid for selection of specific antidepressant drugs in patients with endogenous_depression .
2409527	0	Dexamethasone	0,13	alpha-fetoprotein	23,40	Dexamethasone	alpha-fetoprotein	MESH:D003907	24177(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|transcription transcription|amod|END_ENTITY	Dexamethasone inhibits alpha-fetoprotein gene transcription in neonatal rat liver and isolated nuclei .
1718836	0	Dexamethasone	0,13	alpha_2-macroglobulin	24,45	Dexamethasone	alpha 2-macroglobulin	MESH:D003907	24153(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	Dexamethasone modulates alpha_2-macroglobulin and apolipoprotein_E gene expression in cultured rat liver fat-storing -LRB- Ito -RRB- cells .
18485896	0	Dexamethasone	0,13	angiopoietin-1	37,51	Dexamethasone	angiopoietin-1	MESH:D003907	284	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	Dexamethasone coordinately regulates angiopoietin-1 and VEGF : a mechanism of glucocorticoid-induced stabilization of blood-brain barrier .
1328818	0	Dexamethasone	0,13	apolipoprotein_A-I	24,42	Dexamethasone	apolipoprotein A-I	MESH:D003907	335	Chemical	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	Dexamethasone increases apolipoprotein_A-I concentrations in medium and apolipoprotein_A-I mRNA abundance from Hep G2 cells .
26578982	0	Dexamethasone	0,13	aquaporin-2	24,35	Dexamethasone	aquaporin-2	MESH:D003907	359	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Dexamethasone increases aquaporin-2 protein expression in ex vivo inner medullary collecting duct suspensions .
17240062	0	Dexamethasone	0,13	aquaporin-4	34,45	Dexamethasone	aquaporin-4	MESH:D003907	25293(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY modulates|nsubj|treatment modulates|dobj|expression expression|amod|END_ENTITY	Dexamethasone treatment modulates aquaporin-4 expression after intracerebral_hemorrhage in rats .
9427511	0	Dexamethasone	0,13	basic_fibroblast_growth_factor	24,54	Dexamethasone	basic fibroblast growth factor	MESH:D003907	2247	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Dexamethasone regulates basic_fibroblast_growth_factor , nerve_growth_factor and S100beta expression in cultured hippocampal astrocytes .
1313684	0	Dexamethasone	0,13	beta-endorphin	52,66	Dexamethasone	beta-endorphin	MESH:D003907	5443	Chemical	Gene	suppression|amod|START_ENTITY induced|nsubj|suppression induced|dobj|secretion secretion|amod|END_ENTITY	Dexamethasone suppression of the calcitonin induced beta-endorphin , ACTH and cortisol secretion .
6250217	0	Dexamethasone	0,13	beta-endorphin	32,46	Dexamethasone	beta-endorphin	MESH:D003907	5443	Chemical	Gene	fails|nsubj|START_ENTITY fails|xcomp|suppress suppress|dobj|concentrations concentrations|amod|END_ENTITY	Dexamethasone fails to suppress beta-endorphin plasma concentrations in humans and rhesus_monkeys .
14688340	0	Dexamethasone	0,13	c-Jun_N-terminal_kinase	133,156	Dexamethasone	c-Jun N-terminal kinase	MESH:D003907	5599	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|down-regulating down-regulating|dobj|activity activity|nmod|END_ENTITY	Dexamethasone inhibits IL-12p40 production in lipopolysaccharide-stimulated human monocytic cells by down-regulating the activity of c-Jun_N-terminal_kinase , the activation protein-1 , and NF-kappa B transcription factors .
16167066	0	Dexamethasone	0,13	cFLIP	110,115	Dexamethasone	cFLIP	MESH:D003907	12633(Tax:10090)	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|upregulation upregulation|nmod|END_ENTITY	Dexamethasone protects primary cultured hepatocytes from death receptor-mediated apoptosis by upregulation of cFLIP .
23271276	0	Dexamethasone	0,13	carboxylesterase_1	51,69	Dexamethasone	carboxylesterase 1	MESH:D003907	29225(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Dexamethasone regulates differential expression of carboxylesterase_1 and carboxylesterase_2 through activation of nuclear receptors .
23426970	0	Dexamethasone	0,13	caveolin-1	22,32	Dexamethasone	caveolin-1	MESH:D003907	857	Chemical	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Dexamethasone induces caveolin-1 in vascular endothelial cells : implications for attenuated responses to VEGF .
25688118	0	Dexamethasone	0,13	caveolin-1	28,38	Dexamethasone	caveolin-1	MESH:D003907	12389(Tax:10090)	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|muscle_atrophy muscle_atrophy|amod|END_ENTITY	Dexamethasone downregulates caveolin-1 causing muscle_atrophy via inhibited insulin signaling .
16507889	0	Dexamethasone	0,13	connective_tissue_growth_factor	22,53	Dexamethasone	connective tissue growth factor	MESH:D003907	14219(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Dexamethasone induces connective_tissue_growth_factor expression in renal tubular epithelial cells in a mouse_strain-specific manner .
11093784	0	Dexamethasone	0,13	constitutive_androstane_receptor	23,55	Dexamethasone	constitutive androstane receptor	MESH:D003907	9970	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	Dexamethasone enhances constitutive_androstane_receptor expression in human hepatocytes : consequences on cytochrome P450 gene regulation .
3499580	0	Dexamethasone	0,13	corticotropin-releasing_factor	23,53	Dexamethasone	corticotropin-releasing factor	MESH:D003907	81648(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Dexamethasone inhibits corticotropin-releasing_factor gene expression in the rat paraventricular nucleus .
20080405	0	Dexamethasone	0,13	dysferlin	22,31	Dexamethasone	dysferlin	MESH:D003907	26903(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Dexamethasone induces dysferlin in myoblasts and enhances their myogenic differentiation .
10484530	0	Dexamethasone	0,13	eNOS	24,28	Dexamethasone	eNOS	MESH:D003907	24600(Tax:10116)	Chemical	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	Dexamethasone increases eNOS gene expression and prevents renal vasoconstriction induced by cyclosporin .
15598872	0	Dexamethasone	0,13	eNOS	25,29	Dexamethasone	eNOS	MESH:D003907	18127(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	Dexamethasone suppresses eNOS and CAT-1 and induces oxidative stress in mouse resistance arterioles .
8024561	0	Dexamethasone	0,13	elastin	25,32	Dexamethasone	elastin	MESH:D003907	2006	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Dexamethasone suppresses elastin gene expression in human skin fibroblasts in culture .
12573655	0	Dexamethasone	0,13	endothelin-1	24,36	Dexamethasone	endothelin-1	MESH:D003907	1906	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|receptors receptors|amod|END_ENTITY	Dexamethasone regulates endothelin-1 and endothelin receptors in human_non-pigmented_ciliary_epithelial -LRB- HNPE -RRB- cells .
1381021	0	Dexamethasone	0,13	endothelin-1	73,85	Dexamethasone	endothelin-1	MESH:D003907	1906	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|production production|nmod|inositol_trisphosphate inositol_trisphosphate|acl|evoked evoked|nmod|cells cells|amod|END_ENTITY	Dexamethasone potentiates production of inositol_trisphosphate evoked by endothelin-1 in vascular smooth muscle cells .
22209709	0	Dexamethasone	0,13	endothelin-1	25,37	Dexamethasone	endothelin-1	MESH:D003907	13614(Tax:10090)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Dexamethasone stimulates endothelin-1 gene expression in renal collecting_duct cells .
19137832	0	Dexamethasone	0,13	fas_ligand	25,35	Dexamethasone	fas ligand	MESH:D003907	14103(Tax:10090)	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|expression expression|amod|END_ENTITY	Dexamethasone effects on fas_ligand expression in mouse testicular germ cells .
14698533	0	Dexamethasone	0,13	gastrin-releasing_peptide_receptor	28,62	Dexamethasone	gastrin-releasing peptide receptor	MESH:D003907	2925	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Dexamethasone regulation of gastrin-releasing_peptide_receptor in human lung cells .
22120831	0	Dexamethasone	0,13	ghrelin	43,50	Dexamethasone	ghrelin	MESH:D003907	59301(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|nmod|END_ENTITY	Dexamethasone stimulates the expression of ghrelin and its receptor in rat hypothalamic 4B cells .
16792589	0	Dexamethasone	0,13	glucocorticoid-induced_leucine_zipper	34,71	Dexamethasone	glucocorticoid-induced leucine zipper	MESH:D003907	1831	Chemical	Gene	stimulate|nsubj|START_ENTITY stimulate|dobj|synthesis synthesis|amod|END_ENTITY	Dexamethasone and IL-10 stimulate glucocorticoid-induced_leucine_zipper synthesis by human mast cells .
12639897	0	Dexamethasone	0,13	glucocorticoid_receptor	177,200	Dexamethasone	glucocorticoid receptor	MESH:D003907	2908	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|serine-phosphorylation serine-phosphorylation|nmod|annexin_1 annexin_1|nmod|line line|nmod|mechanism mechanism|nmod|END_ENTITY	Dexamethasone induces rapid serine-phosphorylation and membrane translocation of annexin_1 in a human folliculostellate cell line via a novel nongenomic mechanism involving the glucocorticoid_receptor , protein_kinase_C , phosphatidylinositol 3-kinase , and mitogen-activated protein kinase .
12781044	0	Dexamethasone	11,24	glucocorticoid_receptor	28,51	Dexamethasone	glucocorticoid receptor	MESH:D003907	2908	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effects of Dexamethasone on glucocorticoid_receptor expression in a human ovarian_carcinoma cell line 3AO .
1342065	0	Dexamethasone	0,13	glucocorticoid_receptor	23,46	Dexamethasone	glucocorticoid receptor	MESH:D003907	2908	Chemical	Gene	reverses|nsubj|START_ENTITY reverses|dobj|depression depression|compound|END_ENTITY	Dexamethasone reverses glucocorticoid_receptor RNA depression in multi-drug resistant -LRB- MDR -RRB- myeloma cell lines .
15572593	0	Dexamethasone	0,13	glucocorticoid_receptor	149,172	Dexamethasone	glucocorticoid receptor	MESH:D003907	2908	Chemical	Gene	resistance|amod|START_ENTITY occurs|nsubj|resistance occurs|dobj|downstream downstream|nmod|translocation translocation|nmod|END_ENTITY	Dexamethasone resistance in B-cell precursor childhood acute_lymphoblastic_leukemia occurs downstream of ligand-induced nuclear translocation of the glucocorticoid_receptor .
19153071	0	Dexamethasone	0,13	glucocorticoid_receptor	82,105	Dexamethasone	glucocorticoid receptor	MESH:D003907	2908	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|acl|regardless regardless|nmod:npmod|END_ENTITY	Dexamethasone enhances basal and TNF-alpha-stimulated production of PAI-1 via the glucocorticoid_receptor regardless of 11beta-hydroxysteroid dehydrogenase 2 status in human proximal renal tubular cells .
22237309	0	Dexamethasone	0,13	glucocorticoid_receptor	87,110	Dexamethasone	glucocorticoid receptor	MESH:D003907	2908	Chemical	Gene	expression|amod|START_ENTITY marker|nsubj|expression marker|nmod|resistance resistance|compound|END_ENTITY	Dexamethasone stimulated gene expression in peripheral blood is a sensitive marker for glucocorticoid_receptor resistance in depressed patients .
8643461	0	Dexamethasone	0,13	glucocorticoid_receptor	115,138	Dexamethasone	glucocorticoid receptor	MESH:D003907	2908	Chemical	Gene	responsiveness|amod|START_ENTITY mediated|nsubjpass|responsiveness mediated|nmod|elements elements|amod|unrelated unrelated|nmod|motif motif|compound|END_ENTITY	Dexamethasone responsiveness of a major glucocorticoid-inducible CYP3A gene is mediated by elements unrelated to a glucocorticoid_receptor binding motif .
8418701	0	Dexamethasone	0,13	glutaminase	29,40	Dexamethasone	glutaminase	MESH:D003907	24398(Tax:10116)	Chemical	Gene	stimulation|amod|START_ENTITY stimulation|nmod|expression expression|amod|END_ENTITY	Dexamethasone stimulation of glutaminase expression in mesenteric lymph nodes .
7835947	0	Dexamethasone	0,13	granulocyte-macrophage_colony-stimulating_factor	27,75	Dexamethasone	granulocyte-macrophage colony-stimulating factor	MESH:D003907	1437	Chemical	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|amod|END_ENTITY	Dexamethasone up-regulates granulocyte-macrophage_colony-stimulating_factor receptor expression on human monocytes .
1373684	0	Dexamethasone	0,13	granulocyte_colony-stimulating_factor	53,90	Dexamethasone	granulocyte colony-stimulating factor	MESH:D003907	1440	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|ccomp|necrosis necrosis|dobj|production production|amod|END_ENTITY	Dexamethasone inhibits tumor necrosis factor-induced granulocyte_colony-stimulating_factor production in human endothelial cells .
9367827	0	Dexamethasone	0,13	granulocyte_colony-stimulating_factor	82,119	Dexamethasone	granulocyte colony-stimulating factor	MESH:D003907	1440	Chemical	Gene	potently|amod|START_ENTITY synergize|nsubj|potently synergize|xcomp|stimulate stimulate|dobj|production production|nmod|END_ENTITY	Dexamethasone and interleukin-1 potently synergize to stimulate the production of granulocyte_colony-stimulating_factor in differentiated THP-1 cells .
10502457	0	Dexamethasone	0,13	growth_hormone	28,42	Dexamethasone	growth hormone	MESH:D003907	81668(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Dexamethasone inhibits both growth_hormone -LRB- GH -RRB- - induction of insulin-like_growth_factor-I -LRB- IGF-I -RRB- mRNA and GH_receptor -LRB- GHR -RRB- mRNA levels in rat primary cultured hepatocytes .
1955500	0	Dexamethasone	0,13	growth_hormone	58,72	Dexamethasone	growth hormone	MESH:D003907	2688	Chemical	Gene	treatment|amod|START_ENTITY induces|nsubj|treatment induces|dobj|changes changes|nmod|END_ENTITY	Dexamethasone treatment in man induces changes in 24-hour growth_hormone -LRB- GH -RRB- secretion profile without altering total GH released .
2583364	0	Dexamethasone	0,13	growth_hormone	25,39	Dexamethasone	growth hormone	MESH:D003907	81668(Tax:10116)	Chemical	Gene	control|amod|START_ENTITY control|nmod|levels levels|amod|END_ENTITY	Dexamethasone control of growth_hormone mRNA levels in GH3 pituitary cells is cycloheximide-sensitive and primarily posttranscriptional .
7678792	0	Dexamethasone	0,13	growth_hormone	31,45	Dexamethasone	growth hormone	MESH:D003907	81668(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Dexamethasone induces advanced growth_hormone expression in the fetal rat pituitary gland in vivo .
9579236	0	Dexamethasone	0,13	growth_hormone	43,57	Dexamethasone	growth hormone	MESH:D003907	2688	Chemical	Gene	START_ENTITY|nmod|work-up work-up|nmod|deficiency deficiency|amod|END_ENTITY	Dexamethasone in the diagnostic work-up of growth_hormone deficiency .
11508649	0	Dexamethasone	0,13	iNOS	25,29	Dexamethasone	iNOS	MESH:D003907	24599(Tax:10116)	Chemical	Gene	suppresses|amod|START_ENTITY END_ENTITY|nsubj|suppresses	Dexamethasone suppresses iNOS gene expression by inhibiting NF-kappaB in vascular smooth muscle cells .
19373131	0	Dexamethasone	0,13	iNOS	40,44	Dexamethasone	iNOS	MESH:D003907	24599(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|induction induction|nmod|expression expression|amod|END_ENTITY	Dexamethasone inhibits the induction of iNOS gene expression through destabilization of its mRNA in proinflammatory cytokine-stimulated hepatocytes .
9435553	0	Dexamethasone	0,13	iNOS	25,29	Dexamethasone	iNOS	MESH:D003907	24599(Tax:10116)	Chemical	Gene	suppresses|amod|START_ENTITY END_ENTITY|nsubj|suppresses	Dexamethasone suppresses iNOS gene expression by upregulating I-kappa_B_alpha and inhibiting NF-kappa B. Cytokine-stimulated inducible nitric_oxide synthase -LRB- iNOS -RRB- gene expression is dependent on nuclear factor-kappa B -LRB- NF-kappa B -RRB- activation and is suppressed by glucocorticoids -LRB- GC -RRB- .
12181447	0	Dexamethasone	0,13	inducible_nitric-oxide_synthase	23,54	Dexamethasone	inducible nitric-oxide synthase	MESH:D003907	18126(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Dexamethasone inhibits inducible_nitric-oxide_synthase expression and nitric_oxide production by destabilizing mRNA in lipopolysaccharide-treated macrophages .
11517149	0	Dexamethasone	0,13	insulin	59,66	Dexamethasone	insulin	MESH:D003907	3630	Chemical	Gene	exacerbates|nsubj|START_ENTITY exacerbates|dobj|resistance resistance|compound|END_ENTITY	Dexamethasone during late gestation exacerbates peripheral insulin resistance and selectively targets glucose-sensitive functions in beta cell and liver .
2169394	0	Dexamethasone	0,13	insulin	23,30	Dexamethasone	insulin	MESH:D003907	3630	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|biosynthesis biosynthesis|compound|END_ENTITY	Dexamethasone inhibits insulin biosynthesis by destabilizing insulin messenger ribonucleic acid in hamster_insulinoma cells .
2169394	0	Dexamethasone	0,13	insulin	61,68	Dexamethasone	insulin	MESH:D003907	3630	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|acid acid|compound|END_ENTITY	Dexamethasone inhibits insulin biosynthesis by destabilizing insulin messenger ribonucleic acid in hamster_insulinoma cells .
2651092	0	Dexamethasone	0,13	insulin	109,116	Dexamethasone	insulin	MESH:D003907	3630	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|system system|dep|mechanisms mechanisms|nmod|resistance resistance|compound|END_ENTITY	Dexamethasone regulates the glucose transport system in primary cultured adipocytes : different mechanisms of insulin resistance after acute and chronic exposure .
3522357	5	Dexamethasone	939,952	insulin	1032,1039	Dexamethasone	insulin	MESH:D003907	3630	Chemical	Gene	amplification|amod|START_ENTITY amplification|nmod|response response|nmod|range range|nmod|concentrations concentrations|compound|END_ENTITY	Dexamethasone amplification of the insulin-stimulated DNA synthetic response over a range of insulin concentrations -LRB- i.e. 1.6-66 .6 nM -RRB- expressed no differences between the two donor groups .
9136082	0	Dexamethasone	0,13	insulin	88,95	Dexamethasone	insulin	MESH:D003907	3630	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|parataxis|inhibition inhibition|nmod|END_ENTITY	Dexamethasone stimulates leptin release from human adipocytes : unexpected inhibition by insulin .
10502457	0	Dexamethasone	0,13	insulin-like_growth_factor-I	61,89	Dexamethasone	insulin-like growth factor-I	MESH:D003907	24482(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|growth_hormone growth_hormone|dep|induction induction|nmod|mRNA mRNA|compound|END_ENTITY	Dexamethasone inhibits both growth_hormone -LRB- GH -RRB- - induction of insulin-like_growth_factor-I -LRB- IGF-I -RRB- mRNA and GH_receptor -LRB- GHR -RRB- mRNA levels in rat primary cultured hepatocytes .
2059879	0	Dexamethasone	0,13	insulin-like_growth_factor-I	65,93	Dexamethasone	insulin-like growth factor-I	MESH:D003907	24482(Tax:10116)	Chemical	Gene	2_vitamin_D3|compound|START_ENTITY modulate|nsubj|2_vitamin_D3 modulate|dobj|synthesis synthesis|nmod|END_ENTITY	Dexamethasone and 1,25 -LRB- OH -RRB- 2_vitamin_D3 modulate the synthesis of insulin-like_growth_factor-I in osteoblast-like cells .
24464002	0	Dexamethasone	0,13	insulin-like_growth_factor-I	24,52	Dexamethasone	insulin-like growth factor-I	MESH:D003907	24482(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|END_ENTITY	Dexamethasone decreases insulin-like_growth_factor-I and - II via a glucocorticoid receptor dependent mechanism in developing rat brain .
7525827	0	Dexamethasone	0,13	insulin-like_growth_factor-I	52,80	Dexamethasone	insulin-like growth factor-I	MESH:D003907	3479	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|effect effect|nmod|END_ENTITY	Dexamethasone potentiates the stimulatory effect of insulin-like_growth_factor-I on collagen production in cultured human fibroblasts .
1696886	0	Dexamethasone	0,13	insulin-like_growth_factor_binding_protein-1	32,76	Dexamethasone	insulin-like growth factor binding protein-1	MESH:D003907	25685(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|mRNA mRNA|amod|END_ENTITY	Dexamethasone increases hepatic insulin-like_growth_factor_binding_protein-1 -LRB- IGFBP-1 -RRB- mRNA and serum IGFBP-1 concentrations in the rat .
6358216	0	Dexamethasone	0,13	insulin_receptor	25,41	Dexamethasone	insulin receptor	MESH:D003907	24954(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|synthesis synthesis|compound|END_ENTITY	Dexamethasone stimulates insulin_receptor synthesis in cultured rat hepatocytes .
7815387	0	Dexamethasone	0,13	insulin_receptor	40,56	Dexamethasone	insulin receptor	MESH:D003907	3643	Chemical	Gene	mediated|nsubj|START_ENTITY mediated|dobj|stabilization stabilization|nmod|mRNA mRNA|compound|END_ENTITY	Dexamethasone mediated stabilization of insulin_receptor mRNA .
8863182	0	Dexamethasone	0,13	insulin_receptor	24,40	Dexamethasone	insulin receptor	MESH:D003907	24954(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|compound|END_ENTITY	Dexamethasone modulates insulin_receptor expression and subcellular distribution of the glucose transporter GLUT_1 in UMR 106-01 , a clonal osteogenic_sarcoma cell line .
8300578	0	Dexamethasone	0,13	insulin_receptor_substrate-1	33,61	Dexamethasone	insulin receptor substrate-1	MESH:D003907	3667	Chemical	Gene	down-regulation|amod|START_ENTITY down-regulation|nmod|END_ENTITY	Dexamethasone down-regulation of insulin_receptor_substrate-1 in 3T3-L1 adipocytes .
10696826	0	Dexamethasone	0,13	intercellular_adhesion_molecule-1	73,106	Dexamethasone	intercellular adhesion molecule-1	MESH:D003907	3383	Chemical	Gene	represses|nsubj|START_ENTITY represses|parataxis|ECV ECV|nsubj|expression expression|nmod|line line|amod|END_ENTITY	Dexamethasone represses 3,5,3 ' - triiodothyronine-stimulated expression of intercellular_adhesion_molecule-1 in the human cell line ECV 304 .
9274931	0	Dexamethasone	0,13	intercellular_adhesion_molecule-1	40,73	Dexamethasone	intercellular adhesion molecule-1	MESH:D003907	3383	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|up-regulation up-regulation|amod|END_ENTITY	Dexamethasone inhibits cytokine-induced intercellular_adhesion_molecule-1 up-regulation on endothelial cell lines .
10517906	0	Dexamethasone	0,13	intercellular_adhesion_molecule_1	96,129	Dexamethasone	intercellular adhesion molecule 1	MESH:D003907	25464(Tax:10116)	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|dep|role role|nmod|END_ENTITY	Dexamethasone inhibition of leucocyte adhesion to rat mesenteric postcapillary venules : role of intercellular_adhesion_molecule_1 and KC .
11022126	0	Dexamethasone	0,13	interleukin-15	47,61	Dexamethasone	interleukin-15	MESH:D003907	3600	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|expression expression|amod|END_ENTITY	Dexamethasone and cyclosporin_A do not inhibit interleukin-15 expression in the human lung_carcinoma cell line A549 .
1451738	0	Dexamethasone	0,13	interleukin-1_beta	63,81	Dexamethasone	interleukin-1 beta	MESH:D003907	3553	Chemical	Gene	attenuates|amod|START_ENTITY altered|nsubj|attenuates altered|dobj|secretion secretion|acl|elicited elicited|nmod|cells cells|amod|END_ENTITY	Dexamethasone attenuates altered insulin secretion elicited by interleukin-1_beta in HIT cells .
1756393	0	Dexamethasone	0,13	interleukin-1_beta	71,89	Dexamethasone	interleukin-1 beta	MESH:D003907	24494(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|suppression suppression|acl|induced induced|nmod|doses doses|nmod|intracerebroventricularly intracerebroventricularly|amod|END_ENTITY	Dexamethasone inhibits food intake suppression induced by low doses of interleukin-1_beta administered intracerebroventricularly .
19664145	0	Dexamethasone	0,13	interleukin-22	25,39	Dexamethasone	interleukin-22	MESH:D003907	500836(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	Dexamethasone suppresses interleukin-22 associated with bacterial_infection in vitro and in vivo .
7922784	0	Dexamethasone	0,13	interleukin-8	56,69	Dexamethasone	interleukin-8	MESH:D003907	3576	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|amod|END_ENTITY	Dexamethasone regulates IL-1_beta and TNF-alpha-induced interleukin-8 production in human bone marrow stromal and osteoblast-like cells .
7528007	0	Dexamethasone	0,13	interleukin_1_beta	37,55	Dexamethasone	interleukin 1 beta	MESH:D003907	3553	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|expression expression|amod|END_ENTITY	Dexamethasone differentially affects interleukin_1_beta - and cyclic_AMP-induced nitric_oxide synthase mRNA expression in renal mesangial cells .
2022743	0	Dexamethasone	0,13	interleukin_2	29,42	Dexamethasone	interleukin 2	MESH:D003907	3558	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Dexamethasone inhibits human interleukin_2 but not interleukin_2 receptor gene expression in vitro at the level of nuclear transcription .
21292384	0	Dexamethasone	0,13	leptin	43,49	Dexamethasone	leptin	MESH:D003907	3952	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|nmod|cells cells|compound|END_ENTITY	Dexamethasone stimulates the expression of leptin and 11b-HSD2 in primary human placental trophoblastic cells .
25049989	0	Dexamethasone	0,13	leptin	47,53	Dexamethasone	leptin	MESH:D003907	280836(Tax:9913)	Chemical	Gene	modulate|nsubj|START_ENTITY modulate|dobj|END_ENTITY	Dexamethasone and acetate modulate cytoplasmic leptin in bovine preadipocytes .
26662513	0	Dexamethasone	0,13	leptin	40,46	Dexamethasone	leptin	MESH:D003907	16846(Tax:10090)	Chemical	Gene	alters|amod|START_ENTITY observed|nsubj|alters observed|advmod|as as|nmod:npmod|insulin insulin|appos|END_ENTITY	Dexamethasone treatment alters insulin , leptin , and adiponectin levels in male mice as observed in DIO but does not lead to alterations of metabolic phenotypes in the offspring .
9013746	0	Dexamethasone	0,13	leptin	65,71	Dexamethasone	leptin	MESH:D003907	3952	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|circulating circulating|dobj|levels levels|compound|END_ENTITY	Dexamethasone induces an acute and sustained rise in circulating leptin levels in normal human subjects .
9141563	0	Dexamethasone	0,13	leptin	24,30	Dexamethasone	leptin	MESH:D003907	3952	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Dexamethasone increases leptin expression in humans in vivo .
8559285	0	Dexamethasone	0,13	lipocortin_1	91,103	Dexamethasone	lipocortin 1	MESH:D003907	25380(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|mechanisms mechanisms|amod|END_ENTITY	Dexamethasone suppresses the release of prolactin from the rat anterior pituitary gland by lipocortin_1 dependent and independent mechanisms .
17707523	9	Dexamethasone	1214,1227	mPGES-1	1275,1282	Dexamethasone	mPGES-1	MESH:D003907	64292(Tax:10090)	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|dobj|expression expression|amod|END_ENTITY	Dexamethasone and MK-886 both inhibited the cytokine-induced mPGES-1 expression while mPGES-2 and cPGES expression remained unaffected .
9492032	0	Dexamethasone	0,13	macrophage_colony-stimulating_factor	52,88	Dexamethasone	macrophage colony-stimulating factor	MESH:D003907	12977(Tax:10090)	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|nmod|END_ENTITY	Dexamethasone promotes expression of membrane-bound macrophage_colony-stimulating_factor in murine osteoblast-like cells .
11357885	0	Dexamethasone	0,13	macrophage_colony_stimulating_factor	51,87	Dexamethasone	macrophage colony stimulating factor	MESH:D003907	1435	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Dexamethasone increases the expression of membrane macrophage_colony_stimulating_factor from retrovirally transduced tumor cells expressing macrophage_colony_stimulating_factor .
10799303	0	Dexamethasone	0,13	macrophage_inflammatory_protein-2	73,106	Dexamethasone	macrophage inflammatory protein-2	MESH:D003907	20310(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Dexamethasone inhibits tumor_necrosis_factor-alpha-induced expression of macrophage_inflammatory_protein-2 and adhesion of neutrophils to endothelial cells .
7737418	0	Dexamethasone	0,13	macrophage_inflammatory_protein-2	56,89	Dexamethasone	macrophage inflammatory protein-2	MESH:D003907	114105(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Dexamethasone inhibits ozone-induced gene expression of macrophage_inflammatory_protein-2 in rat lung .
8666007	0	Dexamethasone	0,13	macrophage_inflammatory_protein_2	41,74	Dexamethasone	macrophage inflammatory protein 2	MESH:D003907	114105(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|nmod|END_ENTITY	Dexamethasone inhibits the production of macrophage_inflammatory_protein_2 in the leukocytes in rat allergic_inflammation .
24244697	0	Dexamethasone	0,13	microRNA-155	47,59	Dexamethasone	microRNA-155	MESH:D003907	387173(Tax:10090)	Chemical	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|nmod|END_ENTITY	Dexamethasone down-regulates the expression of microRNA-155 in the livers of septic mice .
17403137	0	Dexamethasone	0,13	monocyte_chemoattractant_protein-1	25,59	Dexamethasone	monocyte chemoattractant protein-1	MESH:D003907	24770(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|production production|amod|END_ENTITY	Dexamethasone suppresses monocyte_chemoattractant_protein-1 production via mitogen_activated_protein_kinase_phosphatase-1 dependent inhibition of Jun_N-terminal_kinase and p38_mitogen-activated_protein_kinase in activated rat microglia .
9040477	0	Dexamethasone	0,13	monocyte_chemotactic_protein-1	84,114	Dexamethasone	monocyte chemotactic protein-1	MESH:D003907	6347	Chemical	Gene	modulation|compound|START_ENTITY modulation|amod|END_ENTITY	Dexamethasone and cyclosporin_A modulation of human_retinal_pigment_epithelial cell monocyte_chemotactic_protein-1 and interleukin-8 .
10359641	0	Dexamethasone	0,13	multidrug-resistance_protein_2	58,88	Dexamethasone	multidrug-resistance protein 2	MESH:D003907	24891(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Dexamethasone - and osmolarity-dependent expression of the multidrug-resistance_protein_2 in cultured rat hepatocytes .
1319504	0	Dexamethasone	0,13	nerve_growth_factor_receptor	54,82	Dexamethasone	nerve growth factor receptor	MESH:D003907	24596(Tax:10116)	Chemical	Gene	blocks|nsubj|START_ENTITY blocks|dobj|induction induction|nmod|mRNA mRNA|compound|END_ENTITY	Dexamethasone blocks nerve_growth_factor induction of nerve_growth_factor_receptor mRNA in PC12 cells .
8760093	0	Dexamethasone	0,13	neuropeptide_Y	45,59	Dexamethasone	neuropeptide Y	MESH:D003907	109648(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|secretion secretion|compound|END_ENTITY	Dexamethasone rapidly increases hypothalamic neuropeptide_Y secretion in adrenalectomized ob/ob mice .
4061114	0	Dexamethasone	0,13	neurotensin	45,56	Dexamethasone	neurotensin	MESH:D003907	299757(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|release release|nmod|END_ENTITY	Dexamethasone reduces fat-induced release of neurotensin in the rat .
8505856	0	Dexamethasone	0,13	neutral_endopeptidase	47,68	Dexamethasone	neutral endopeptidase	MESH:D003907	4311	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Dexamethasone increases airway epithelial cell neutral_endopeptidase by enhancing transcription and new protein synthesis .
19121329	0	Dexamethasone	0,13	parathyroid_hormone-related_protein	46,81	Dexamethasone	parathyroid hormone-related protein	MESH:D003907	5744	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|nmod|END_ENTITY	Dexamethasone downregulates the expression of parathyroid_hormone-related_protein -LRB- PTHrP -RRB- in mesenchymal stem cells .
9397964	0	Dexamethasone	0,13	parathyroid_hormone-related_protein	28,63	Dexamethasone	parathyroid hormone-related protein	MESH:D003907	5744	Chemical	Gene	START_ENTITY|dobj|regulation regulation|nmod|expression expression|amod|END_ENTITY	Dexamethasone regulation of parathyroid_hormone-related_protein -LRB- PTHrP -RRB- expression in a squamous cancer cell line .
11048649	0	Dexamethasone	0,13	phospholipase_D	23,38	Dexamethasone	phospholipase D	MESH:D003907	2822	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|amod|END_ENTITY	Dexamethasone enhances phospholipase_D activity in M-1 cells .
18568889	0	Dexamethasone	0,13	pigment_epithelium-derived_factor	24,57	Dexamethasone	pigment epithelium-derived factor	MESH:D003907	57104	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Dexamethasone increases pigment_epithelium-derived_factor in perfused human eyes .
15627839	0	Dexamethasone	0,13	plasminogen_activator_inhibitor-1	24,57	Dexamethasone	plasminogen activator inhibitor-1	MESH:D003907	5054	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Dexamethasone increased plasminogen_activator_inhibitor-1 expression on human umbilical vein endothelial cells : an additive effect to tumor_necrosis_factor-alpha .
10908304	0	Dexamethasone	0,13	pregnane_X_receptor	22,41	Dexamethasone	pregnane X receptor	MESH:D003907	8856	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Dexamethasone induces pregnane_X_receptor and retinoid_X_receptor-alpha expression in human hepatocytes : synergistic increase of CYP3A4 induction by pregnane_X_receptor activators .
20599767	0	Dexamethasone	0,13	pregnane_X_receptor	64,83	Dexamethasone	pregnane X receptor	MESH:D003907	84385(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Dexamethasone transcriptionally increases the expression of the pregnane_X_receptor and synergistically enhances pyrethroid_esfenvalerate in the induction of cytochrome P450 3A23 .
12450312	0	Dexamethasone	0,13	prolactin	47,56	Dexamethasone	prolactin	MESH:D003907	5617	Chemical	Gene	START_ENTITY|dobj|secretion secretion|compound|END_ENTITY	Dexamethasone and adrenocorticotropin suppress prolactin secretion in humans .
3930250	0	Dexamethasone	0,13	prolactin	64,73	Dexamethasone	prolactin	MESH:D003907	5617	Chemical	Gene	suppression|amod|START_ENTITY suppression|dep|TSH TSH|dep|END_ENTITY	Dexamethasone suppression and multiple hormonal responses -LRB- TSH , prolactin and growth_hormone -RRB- to TRH in some psychiatric_disorders .
8559285	0	Dexamethasone	0,13	prolactin	40,49	Dexamethasone	prolactin	MESH:D003907	24683(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|release release|nmod|END_ENTITY	Dexamethasone suppresses the release of prolactin from the rat anterior pituitary gland by lipocortin_1 dependent and independent mechanisms .
3863150	0	Dexamethasone	0,13	prostaglandin-9-ketoreductase	30,59	Dexamethasone	prostaglandin-9-ketoreductase	MESH:D003907	100009528(Tax:9986)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Dexamethasone effect on renal prostaglandin-9-ketoreductase activity in the rabbit .
10926554	0	Dexamethasone	0,13	ras-recision	23,35	Dexamethasone	ras-recision	MESH:D003907	16948(Tax:10090)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Dexamethasone enhances ras-recision gene expression in cultured murine fetal lungs : role in development .
11000527	0	Dexamethasone	0,13	ribosomal_protein_L32	25,46	Dexamethasone	ribosomal protein L32	MESH:D003907	28298(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|transcription transcription|amod|END_ENTITY	Dexamethasone stimulates ribosomal_protein_L32 gene transcription in rat myoblasts .
11169201	0	Dexamethasone	0,13	serum_amyloid_A	59,74	Dexamethasone	serum amyloid A	MESH:D003907	6287	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	Dexamethasone , but not IL-1 alone , upregulates acute-phase serum_amyloid_A gene expression and production by cultured human aortic smooth muscle cells .
7902961	0	Dexamethasone	0,13	somatostatin	24,36	Dexamethasone	somatostatin	MESH:D003907	24797(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|levels levels|compound|END_ENTITY	Dexamethasone decreases somatostatin mRNA levels in the periventricular nucleus of the rat hypothalamus .
25150176	0	Dexamethasone	0,13	substance_P	24,35	Dexamethasone	substance P	MESH:D003907	6863	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|compound|END_ENTITY	Dexamethasone decreases substance_P expression in human tendon cells : an in vitro study .
26198442	0	Dexamethasone	0,13	thymic_stromal_lymphopoietin	58,86	Dexamethasone	thymic stromal lymphopoietin	MESH:D003907	53603(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Dexamethasone but not tacrolimus suppresses TNF-a-induced thymic_stromal_lymphopoietin expression in lesional keratinocytes of atopic_dermatitis model .
26198442	0	Dexamethasone	0,13	thymic_stromal_lymphopoietin	58,86	Dexamethasone	thymic stromal lymphopoietin	MESH:D003907	53603(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Dexamethasone but not tacrolimus suppresses TNF-a-induced thymic_stromal_lymphopoietin expression in lesional keratinocytes of atopic_dermatitis model .
6141568	0	Dexamethasone	0,13	transglutaminase	41,57	Dexamethasone	transglutaminase	MESH:D003907	7051	Chemical	Gene	inhibition|amod|START_ENTITY END_ENTITY|nsubj|inhibition	Dexamethasone inhibition of DMSO-induced transglutaminase activity and differentiation of leukemic cells .
1722406	0	Dexamethasone	0,13	tumor_necrosis_factor	68,89	Dexamethasone	tumor necrosis factor	MESH:D003907	103694380	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|dobj|effects effects|nmod|END_ENTITY	Dexamethasone prevents the growth inhibitory effects of recombinant tumor_necrosis_factor in a rat hepatoma cell line Reuber-RC-3 : an association with the changes in the messenger RNA levels for multidrug_resistance gene .
1879140	0	Dexamethasone	0,13	tumor_necrosis_factor	40,61	Dexamethasone	tumor necrosis factor	MESH:D003907	100033834(Tax:9796)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|production production|compound|END_ENTITY	Dexamethasone reduces endotoxin-induced tumor_necrosis_factor activity production in vitro by equine peritoneal macrophages .
2788206	0	Dexamethasone	0,13	tumor_necrosis_factor	58,79	Dexamethasone	tumor necrosis factor	MESH:D003907	21926(Tax:10090)	Chemical	Gene	modulation|nsubj|START_ENTITY modulation|nmod|effects effects|nmod|endotoxin endotoxin|appos|END_ENTITY	Dexamethasone modulation of in vivo effects of endotoxin , tumor_necrosis_factor , and interleukin-1 on liver cytochrome_P-450 , plasma fibrinogen , and serum iron .
3040777	0	Dexamethasone	0,13	tumor_necrosis_factor	72,93	Dexamethasone	tumor necrosis factor	MESH:D003907	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|regulation regulation|nmod|activity activity|nmod|END_ENTITY	Dexamethasone inhibits feedback regulation of the mitogenic activity of tumor_necrosis_factor , interleukin-1 , and epidermal_growth_factor in human fibroblasts .
3377783	0	Dexamethasone	0,13	tumor_necrosis_factor	49,70	Dexamethasone	tumor necrosis factor	MESH:D003907	21926(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	Dexamethasone inhibits the cytotoxic activity of tumor_necrosis_factor .
10807495	0	Dexamethasone	0,13	tumor_necrosis_factor-alpha	76,103	Dexamethasone	tumor necrosis factor-alpha	MESH:D003907	21926(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Dexamethasone inhibits arteriolar leukocyte rolling and adhesion induced by tumor_necrosis_factor-alpha in vivo .
15627839	0	Dexamethasone	0,13	tumor_necrosis_factor-alpha	134,161	Dexamethasone	tumor necrosis factor-alpha	MESH:D003907	7124	Chemical	Gene	expression|amod|START_ENTITY expression|dep|effect effect|nmod|END_ENTITY	Dexamethasone increased plasminogen_activator_inhibitor-1 expression on human umbilical vein endothelial cells : an additive effect to tumor_necrosis_factor-alpha .
21571041	0	Dexamethasone	0,13	tumor_necrosis_factor-alpha	27,54	Dexamethasone	tumor necrosis factor-alpha	MESH:D003907	24835(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|END_ENTITY	Dexamethasone treatment of tumor_necrosis_factor-alpha challenged organ of Corti explants activates nuclear_factor_kappa_B signaling that induces changes in gene expression that favor hair cell survival .
7943184	0	Dexamethasone	0,13	tumor_necrosis_factor-alpha	42,69	Dexamethasone	tumor necrosis factor-alpha	MESH:D003907	24835(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|induction induction|nmod|mRNA mRNA|compound|END_ENTITY	Dexamethasone inhibits induction of liver tumor_necrosis_factor-alpha mRNA and liver growth induced by lead nitrate and ethylene_dibromide .
18670086	0	Dexamethasone	0,13	vascular_endothelial_growth_factor	135,169	Dexamethasone	vascular endothelial growth factor	MESH:D003907	83785(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|accumulation accumulation|nmod|retina retina|nmod|rats rats|acl|reducing reducing|dobj|expression expression|amod|END_ENTITY	Dexamethasone inhibits leukocyte accumulation and vascular permeability in retina of streptozotocin-induced diabetic rats via reducing vascular_endothelial_growth_factor and intercellular_adhesion_molecule-1 expression .
21311201	0	Dexamethasone	0,13	vascular_endothelial_growth_factor	77,111	Dexamethasone	vascular endothelial growth factor	MESH:D003907	83785(Tax:10116)	Chemical	Gene	START_ENTITY|dep|differences differences|nmod|expression expression|compound|END_ENTITY	Dexamethasone and betamethasone for prenatal lung maturation : differences in vascular_endothelial_growth_factor expression and alveolarization in rats .
10484475	0	Dexfenfluramine	0,15	Ca2	71,74	Dexfenfluramine	Ca2	MESH:D020372	54231(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Dexfenfluramine increases pulmonary artery smooth muscle intracellular Ca2 + , independent of membrane potential .
22150679	0	Dexmedetomidine	0,15	AKT	116,119	Dexmedetomidine	AKT	MESH:D020927	24185(Tax:10116)	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|pathway pathway|compound|END_ENTITY	Dexmedetomidine protects against oxygen-glucose_deprivation-induced injury through the I2 imidazoline receptor-PI3K / AKT pathway in rat C6 glioma cells .
26899608	0	Dexmedetomidine	11,26	Interleukin-6	36,49	Dexmedetomidine	Interleukin-6	MESH:D020927	3569	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of Dexmedetomidine on Serum Interleukin-6 , Hemodynamic Stability , and Postoperative_Pain Relief in Elderly Patients under Spinal Anesthesia .
22939552	0	Dexmedetomidine	0,15	high_mobility_group_box_1	42,67	Dexmedetomidine	high mobility group box 1	MESH:D020927	3146	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|nmod|END_ENTITY	Dexmedetomidine inhibits the secretion of high_mobility_group_box_1 from lipopolysaccharide-activated macrophages in vitro .
25082544	0	Dexmedetomidine	0,15	inducible_nitric_oxide_synthase	25,56	Dexmedetomidine	inducible nitric oxide synthase	MESH:D020927	4843	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Dexmedetomidine inhibits inducible_nitric_oxide_synthase in lipopolysaccharide-stimulated microglia by suppression of extracellular_signal-regulated_kinase .
25069417	0	Dexmedetomidine	0,15	interleukin-6	50,63	Dexmedetomidine	interleukin-6	MESH:D020927	24498(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|synthesis synthesis|amod|END_ENTITY	Dexmedetomidine suppresses interleukin-1b-induced interleukin-6 synthesis in rat glial cells .
24429914	0	Dexmedetomidine	0,15	tumor_necrosis_factor-alpha	25,52	Dexmedetomidine	tumor necrosis factor-alpha	MESH:D020927	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Dexmedetomidine inhibits tumor_necrosis_factor-alpha and interleukin_6 in lipopolysaccharide-stimulated astrocytes by suppression of c-Jun N-terminal kinases .
8053597	0	Dextromethorphan	0,16	c-fos	43,48	Dextromethorphan	c-fos	MESH:D003915	2353	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Dextromethorphan inhibits ischemia-induced c-fos expression and delayed neuronal_death in hippocampal neurons .
11502351	0	Dextromethorphan	0,16	tyrosine_hydroxylase	27,47	Dextromethorphan	tyrosine hydroxylase	MESH:D003915	25085(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|mRNA mRNA|amod|END_ENTITY	Dextromethorphan increases tyrosine_hydroxylase mRNA in the mesencephalon of adolescent rats .
15901914	0	Di-n-butyl_phthalate	0,20	constitutive_androstane_receptor	31,63	Di-n-butyl phthalate	constitutive androstane receptor	MESH:D003993	65035(Tax:10116)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Di-n-butyl_phthalate activates constitutive_androstane_receptor and pregnane_X_receptor and enhances the expression of steroid-metabolizing enzymes in the liver of rat fetuses .
15922967	0	DiC14-amidine	87,100	p_1	49,52	DiC14-amidine	p 1	MESH:C089665	22673(Tax:10090)	Chemical	Gene	complexed|nmod|START_ENTITY END_ENTITY|acl|complexed	Vaccination with the recombinant allergen ProDer p_1 complexed with the cationic lipid DiC14-amidine prevents allergic responses to house dust mite .
26035033	0	Diacerein	25,34	IL-1b	58,63	Diacerein	IL-1b	MESH:C025292	3553	Chemical	Gene	Responses|compound|START_ENTITY Responses|compound|END_ENTITY	Combination Therapies of Diacerein and Febuxostat Inhibit IL-1b Responses and Improve Clinical Symptoms in Patients With Refractory Gout .
24816162	0	Diacetyl	0,8	amphiregulin	17,29	Diacetyl	amphiregulin	MESH:D003931	374	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Diacetyl induces amphiregulin shedding in pulmonary epithelial cells and in experimental bronchiolitis_obliterans .
21802511	0	Diacylglycerol	0,14	GPR30	201,206	Diacylglycerol	GPR30	CHEBI:41847	2852	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|nmod|END_ENTITY	Diacylglycerol kinase a mediates 17-b-estradiol-induced proliferation , motility , and anchorage-independent growth of Hec-1A endometrial_cancer cell line through the G protein-coupled estrogen receptor GPR30 .
21294865	0	Diacylglycerol	0,14	TRPC6	70,75	Diacylglycerol	TRPC6	CHEBI:41847	22068(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|vasoconstriction vasoconstriction|nmod|END_ENTITY	Diacylglycerol regulates acute hypoxic pulmonary vasoconstriction via TRPC6 .
3533683	0	Diacylglycerol	0,14	insulin_receptor	29,45	Diacylglycerol	insulin receptor	CHEBI:41847	3643	Chemical	Gene	modulation|amod|START_ENTITY modulation|nmod|END_ENTITY	Diacylglycerol modulation of insulin_receptor from cultured human mononuclear cells .
3391275	0	Diacylglycerol	0,14	phospholipase_A2	26,42	Diacylglycerol	phospholipase A2	CHEBI:41847	151056	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Diacylglycerol stimulates phospholipase_A2 from Swiss 3T3 fibroblasts .
8063019	0	Diacylglycerol	0,14	phospholipase_A2	57,73	Diacylglycerol	phospholipase A2	CHEBI:41847	151056	Chemical	Gene	stimulate|amod|START_ENTITY ram|nsubj|stimulate ram|dobj|END_ENTITY	Diacylglycerol and alkylacylglycerol stimulate ram sperm phospholipase_A2 .
19416640	0	Diacylglycerol	0,14	receptor_for_activated_C_kinase_1	44,77	Diacylglycerol	receptor for activated C kinase 1	CHEBI:41847	10399	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|nmod|END_ENTITY	Diacylglycerol kinase delta associates with receptor_for_activated_C_kinase_1 , RACK1 .
8581560	0	Dialkyldithiocarbamates	0,23	tyrosine_hydroxylase	32,52	Dialkyldithiocarbamates	tyrosine hydroxylase	null	25085(Tax:10116)	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|activity activity|amod|END_ENTITY	Dialkyldithiocarbamates inhibit tyrosine_hydroxylase activity in PC12 cells and in fibroblasts that express tyrosine_hydroxylase .
24922637	0	Diallyl_disulfide	0,17	CCL2	40,44	Diallyl disulfide	CCL2	MESH:C028009	6347	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|compound|END_ENTITY	Diallyl_disulfide inhibits TNFa-induced CCL2 release by MDA-MB-231 cells .
12949385	0	Diallyl_disulfide	0,17	ERK	26,29	Diallyl disulfide	ERK	MESH:C028009	5594	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Diallyl_disulfide induces ERK phosphorylation and alters gene expression profiles in human colon_tumor cells .
21618303	0	Diallyl_disulfide	0,17	ERK2	47,51	Diallyl disulfide	ERK2	MESH:C028009	5594	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Diallyl_disulfide induces MUC5B expression via ERK2 in human airway epithelial cells .
21038848	0	Diallyl_disulfide	0,17	JNK	88,91	Diallyl disulfide	JNK	MESH:C028009	5599	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Diallyl_disulfide induces apoptosis in human leukemia HL-60 cells through activation of JNK mediated by reactive oxygen .
21618303	0	Diallyl_disulfide	0,17	MUC5B	26,31	Diallyl disulfide	MUC5B	MESH:C028009	727897	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nummod|END_ENTITY	Diallyl_disulfide induces MUC5B expression via ERK2 in human airway epithelial cells .
11925476	0	Diallyl_disulfide	0,17	NSAID-activated_gene	53,73	Diallyl disulfide	NSAID-activated gene	MESH:C028009	9518	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Diallyl_disulfide -LRB- DADS -RRB- induces the antitumorigenic NSAID-activated_gene -LRB- NAG-1 -RRB- by a p53-dependent mechanism in human colorectal HCT 116 cells .
23851184	0	Diallyl_disulfide	0,17	Wnt-1	97,102	Diallyl disulfide	Wnt-1	MESH:C028009	7471	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	Diallyl_disulfide suppresses proliferation and induces apoptosis in human gastric_cancer through Wnt-1 signaling pathway by up-regulation of miR-200b and miR-22 .
15474518	0	Diallyl_disulfide	0,17	multidrug_resistance-associated_protein_2	62,103	Diallyl disulfide	multidrug resistance-associated protein 2	MESH:C028009	1244	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Diallyl_disulfide , a chemopreventive agent in garlic , induces multidrug_resistance-associated_protein_2 expression .
20932246	0	Diallyl_disulfide	0,17	p53	141,144	Diallyl disulfide	p53	MESH:C028009	22060(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Diallyl_disulfide induces caspase-dependent apoptosis via mitochondria-mediated intrinsic pathway in B16F-10 melanoma cells by up-regulating p53 , caspase-3 and down-regulating pro-inflammatory cytokines and nuclear factor-kb-mediated Bcl-2 activation .
17804871	0	Diallyl_disulfide	0,17	signal_transducer_and_activator_of_transcription_1	26,76	Diallyl disulfide	signal transducer and activator of transcription 1	MESH:C028009	6772	Chemical	Gene	induced|nsubj|START_ENTITY induced|dobj|expression expression|amod|END_ENTITY	Diallyl_disulfide induced signal_transducer_and_activator_of_transcription_1 expression in human colon_cancer colo 205 cells using differential display RT-PCR .
11350212	0	Diallyl_sulfide	0,15	CYP2E1	30,36	Diallyl sulfide	CYP2E1	MESH:C038491	25086(Tax:10116)	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Diallyl_sulfide inhibition of CYP2E1 does not rescue diabetic rats from thioacetamide-induced mortality .
15542064	0	Diallyl_sulfide	0,15	heme_oxygenase-1	24,40	Diallyl sulfide	heme oxygenase-1	MESH:C038491	3162	Chemical	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Diallyl_sulfide induces heme_oxygenase-1 through MAPK pathway .
21424116	0	Diallyl_sulfide	0,15	p53	104,107	Diallyl sulfide	p53	MESH:C038491	7157	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Diallyl_sulfide induces cell cycle arrest and apoptosis in HeLa human cervical_cancer cells through the p53 , caspase - and mitochondria-dependent pathways .
23530650	0	Diallyl_sulfide	0,15	p53	55,58	Diallyl sulfide	p53	MESH:C038491	7157	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|expression expression|compound|END_ENTITY	Diallyl_sulfide promotes cell-cycle arrest through the p53 expression and triggers induction of apoptosis via caspase - and mitochondria-dependent signaling pathways in human cervical_cancer Ca Ski cells .
23046979	0	Diallyl_tetrasulfane	0,20	eIF2a	40,45	Diallyl tetrasulfane	eIF2a	null	1965	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Diallyl_tetrasulfane activates both the eIF2a and Nrf2/HO -1 pathways .
18800351	0	Diallyl_trisulfide	0,18	Bax	38,41	Diallyl trisulfide	Bax	MESH:C042577	581	Chemical	Gene	causes|nsubj|START_ENTITY causes|dobj|apoptosis apoptosis|amod|END_ENTITY	Diallyl_trisulfide selectively causes Bax - and Bak-mediated apoptosis in human lung_cancer cells .
22981381	0	Diallyl_trisulfide	0,18	JNK	101,104	Diallyl trisulfide	JNK	MESH:C042577	5599	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Diallyl_trisulfide induces apoptosis in human breast_cancer cells through ROS-mediated activation of JNK and AP-1 .
24487688	0	Diallyl_trisulfide	0,18	estrogen_receptor-a	28,47	Diallyl trisulfide	estrogen receptor-a	MESH:C042577	2099	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Diallyl_trisulfide inhibits estrogen_receptor-a activity in human breast_cancer cells .
20959517	0	Diallyl_trisulfide	0,18	signal_transducer_and_activator_of_transcription_3	42,92	Diallyl trisulfide	signal transducer and activator of transcription 3	MESH:C042577	6774	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	Diallyl_trisulfide inhibits activation of signal_transducer_and_activator_of_transcription_3 in prostate_cancer cells in culture and in vivo .
16110831	0	Diallyl_trisulfide	0,18	tumor_necrosis_factor-alpha	28,55	Diallyl trisulfide	tumor necrosis factor-alpha	MESH:C042577	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Diallyl_trisulfide inhibits tumor_necrosis_factor-alpha expression in inflammed mucosa of ulcerative_colitis .
16484575	0	Diallylsulfide	0,14	CYP2E1	104,110	Diallylsulfide	CYP2E1	MESH:C038491	1571	Chemical	Gene	effective|nsubj|START_ENTITY effective|advcl|inhibiting inhibiting|dobj|protein protein|compound|END_ENTITY	Diallylsulfide and allylmethylsulfide are uniquely effective among organosulfur compounds in inhibiting CYP2E1 protein in animal models .
1794265	0	Diamicron	14,23	insulin	55,62	Diamicron	insulin	MESH:D005907	3630	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|nmod|END_ENTITY	The effect of Diamicron on the secretion and action of insulin .
19525110	0	Diaminocyclobutenediones	0,24	CXCR2	59,64	Diaminocyclobutenediones	CXCR2	null	3579	Chemical	Gene	START_ENTITY|nmod|antagonists antagonists|amod|END_ENTITY	Diaminocyclobutenediones as potent and orally bioavailable CXCR2 receptor antagonists : SAR in the phenolic_amide region .
22540007	0	Diammonium_glycyrrhizinate	0,26	PGC-1a	39,45	Diammonium glycyrrhizinate	PGC-1a	MESH:D019695	19017(Tax:10090)	Chemical	Gene	upregulates|amod|START_ENTITY END_ENTITY|nsubj|upregulates	Diammonium_glycyrrhizinate upregulates PGC-1a and protects against Ab1-42-induced neurotoxicity .
24270971	0	Diaryl-substituted_ortho-carboranes	0,35	hypoxia_inducible_factor-1a	54,81	Diaryl-substituted ortho-carboranes	hypoxia inducible factor-1a	null	3091	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Diaryl-substituted_ortho-carboranes as a new class of hypoxia_inducible_factor-1a inhibitors .
21120579	0	Diarylheptanoid_hirsutenone	0,27	TRAIL	57,62	Diarylheptanoid hirsutenone	TRAIL	null	8743	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|effect effect|nmod|END_ENTITY	Diarylheptanoid_hirsutenone enhances apoptotic effect of TRAIL on epithelial_ovarian_carcinoma cell lines via activation of death receptor and mitochondrial pathway .
27000851	0	Diarylurea	17,27	TRPV1	57,62	Diarylurea	TRPV1	null	7442	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|nmod|END_ENTITY	Multi-Functional Diarylurea Small Molecule Inhibitors of TRPV1 with Therapeutic Potential for Neuroinflammation .
6712779	0	Diazepam	0,8	ACAT	57,61	Diazepam	ACAT	MESH:D003975	100009537(Tax:9986)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Diazepam inhibits cholesterol esterification by arterial ACAT and plasma LCAT , in vitro .
10363938	0	Diazepam	0,8	FGF-2	17,22	Diazepam	FGF-2	MESH:D003975	54250(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Diazepam induces FGF-2 and its mRNA in the spinal cord .
11113582	0	Diazepam	0,8	FGF-2	17,22	Diazepam	FGF-2	MESH:D003975	2247	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|mRNA mRNA|compound|END_ENTITY	Diazepam induces FGF-2 mRNA in the hippocampus and striatum .
16757081	0	Diazinon	0,8	P450	77,81	Diazinon	P450	MESH:D003976	1555	Chemical	Gene	metabolised|nsubjpass|START_ENTITY metabolised|nmod|END_ENTITY	Diazinon , chlorpyrifos and parathion are metabolised by multiple cytochromes P450 in human liver .
25751089	0	Diazirine	0,9	FTO	47,50	Diazirine	FTO	MESH:D003978	79068	Chemical	Gene	Complexes|compound|START_ENTITY Complexes|compound|END_ENTITY	Diazirine Photocrosslinking Recruits Activated FTO Demethylase Complexes for Specific N -LRB- 6 -RRB- - methyladenosine Recognition .
17402858	0	Diazoxide	0,9	HSP25	80,85	Diazoxide	HSP25	MESH:D003981	24471(Tax:10116)	Chemical	Gene	increases|advmod|START_ENTITY increases|dobj|END_ENTITY	Diazoxide , as a postconditioning and delayed preconditioning trigger , increases HSP25 and HSP70 in the central nervous system following combined cerebral_stroke and hemorrhagic_shock .
18222477	0	Diazoxide	0,9	HSP25	37,42	Diazoxide	HSP25	MESH:D003981	24471(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Diazoxide increases liver and kidney HSP25 and HSP70 after shock and stroke .
11390019	0	Diazoxide	0,9	NPY	57,60	Diazoxide	NPY	MESH:D003981	24604(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|content content|compound|END_ENTITY	Diazoxide effects on hypothalamic and extra-hypothalamic NPY content in Zucker rats .
12865318	0	Diazoxide	0,9	insulin	60,67	Diazoxide	insulin	MESH:D003981	3630	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|nmod|release release|compound|END_ENTITY	Diazoxide attenuates glucose-induced defects in first-phase insulin release and pulsatile insulin secretion in human islets .
8826981	0	Diazoxide	0,9	insulin	48,55	Diazoxide	insulin	MESH:D003981	3630	Chemical	Gene	treatment|amod|START_ENTITY preserves|nsubj|treatment preserves|dobj|secretion secretion|compound|END_ENTITY	Diazoxide treatment at onset preserves residual insulin secretion in adults with autoimmune diabetes .
1223945	0	Diazoxide	1,10	renin	90,95	Diazoxide	renin	MESH:D003981	5972	Chemical	Gene	test|nsubj|START_ENTITY test|nmod|diagnosis diagnosis|dep|modifications modifications|nmod|levels levels|nmod|END_ENTITY	-LSB- Diazoxide test in the diagnosis of arterial hypertension : modifications in the levels of renin and aldosterone in blood of patients with various restrains of the renal function -RSB- .
22496480	0	Dibenzophenanthridines	0,22	glutaminase_C	40,53	Dibenzophenanthridines	glutaminase C	null	2744	Chemical	Gene	START_ENTITY|nmod|proliferation proliferation|compound|END_ENTITY	Dibenzophenanthridines as inhibitors of glutaminase_C and cancer cell proliferation .
23270382	0	Dibenzosuberones	0,16	p38	20,23	Dibenzosuberones	p38	null	1432	Chemical	Gene	START_ENTITY|nmod|protein protein|amod|END_ENTITY	Dibenzosuberones as p38 mitogen-activated protein kinase inhibitors with low ATP competitiveness and outstanding whole blood activity .
12646199	0	Dibenzoylmethane	0,16	HIF-1_alpha	54,65	Dibenzoylmethane	HIF-1 alpha	MESH:C061481	3091	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Dibenzoylmethane , a natural dietary compound , induces HIF-1_alpha and increases expression of VEGF .
12646199	0	Dibenzoylmethane	0,16	VEGF	94,98	Dibenzoylmethane	VEGF	MESH:C061481	7422	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Dibenzoylmethane , a natural dietary compound , induces HIF-1_alpha and increases expression of VEGF .
2155693	0	Dibutyryl_cyclic_AMP	0,20	vimentin	29,37	Dibutyryl cyclic AMP	vimentin	MESH:D003994	22352(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Dibutyryl_cyclic_AMP induces vimentin and GFAP expression in cultured medulloblastoma cells .
17177968	0	Diclofenac	0,10	CD63	61,65	Diclofenac	CD63	MESH:D004008	967	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|expression expression|compound|END_ENTITY	Diclofenac induces basophil degranulation without increasing CD63 expression in sensitive patients .
21268133	0	Diclofenac	0,10	COX-2	24,29	Diclofenac	COX-2	MESH:D004008	29527(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Diclofenac , a selective COX-2 inhibitor , inhibits DMH-induced colon tumorigenesis through suppression of MCP-1 , MIP-1a and VEGF .
23322320	0	Diclofenac	0,10	aquaporin-4	53,64	Diclofenac	aquaporin-4	MESH:D004008	361	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Diclofenac enhances proinflammatory cytokine-induced aquaporin-4 expression in cultured astrocyte .
11221916	0	Diclofenac	0,10	cyclooxygenase-2	35,51	Diclofenac	cyclooxygenase-2	MESH:D004008	397590(Tax:9823)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Diclofenac and NS-398 , a selective cyclooxygenase-2 inhibitor , decrease agonist-induced contractions of the pig isolated ureter .
18347135	0	Dicoumarol	0,10	Hsp90	84,89	Dicoumarol	Hsp90	MESH:D001728	3320	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Dicoumarol down-regulates human PTTG1/Securin mRNA expression through inhibition of Hsp90 .
11709300	0	Dicyclic_and_tricyclic_diaminopyrimidine	0,40	dihydrofolate_reductase	100,123	Dicyclic and tricyclic diaminopyrimidine	dihydrofolate reductase	null	1719	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|inhibitors inhibitors|nmod|END_ENTITY	Dicyclic_and_tricyclic_diaminopyrimidine derivatives as potent inhibitors of Cryptosporidium_parvum dihydrofolate_reductase : structure-activity and structure-selectivity correlations .
23537712	0	Didecyldimethylammonium_chloride	0,32	TGF-b	80,85	Didecyldimethylammonium chloride	TGF-b	MESH:C027118	21803(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Didecyldimethylammonium_chloride induces pulmonary_fibrosis in association with TGF-b signaling in mice .
25767055	0	Dienogest	0,9	HSD17b1	18,25	Dienogest	HSD17b1	MESH:C023635	3292	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|amod|END_ENTITY	Dienogest reduces HSD17b1 expression and activity in endometriosis .
22014880	0	Dienogest	0,9	Toll-like_receptor_4	19,39	Dienogest	Toll-like receptor 4	MESH:C023635	7099	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Dienogest inhibits Toll-like_receptor_4 expression induced by costimulation of lipopolysaccharide and high-mobility_group_box_1 in endometrial epithelial cells .
19142217	0	Diethyl_dithiocarbamic_acid	0,27	nuclear_factor_kappa_B	40,62	Diethyl dithiocarbamic acid	nuclear factor kappa B	MESH:D004050	18033(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Diethyl_dithiocarbamic_acid , a possible nuclear_factor_kappa_B inhibitor , attenuates ischemic postconditioning-induced attenuation of cerebral_ischemia-reperfusion injury in mice .
3296835	0	Diethyl_ether	0,13	alcohol_dehydrogenase	70,91	Diethyl ether	alcohol dehydrogenase	MESH:D004986	78959(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|interaction interaction|nmod|END_ENTITY	Diethyl_ether inhibits ethanol metabolism in vivo by interaction with alcohol_dehydrogenase .
3340079	0	Diethyl_ether	0,13	cytochrome_P-450	59,75	Diethyl ether	cytochrome P-450	MESH:D004986	25251(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|substrate substrate|nmod|END_ENTITY	Diethyl_ether as a substrate for acetone/ethanol-inducible cytochrome_P-450 and as an inducer for cytochrome -LRB- s -RRB- P-450 .
23977034	0	Diethylhexyl_phthalates	0,23	insulin	43,50	Diethylhexyl phthalates	insulin	null	3630	Chemical	Gene	associated|nsubjpass|START_ENTITY associated|nmod|resistance resistance|compound|END_ENTITY	Diethylhexyl_phthalates is associated with insulin resistance via oxidative stress in the elderly : a panel study .
7250488	0	Diethylpyrocarbonate	0,20	estradiol_receptor	35,53	Diethylpyrocarbonate	estradiol receptor	MESH:D004047	407238(Tax:9913)	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Diethylpyrocarbonate inhibition of estradiol_receptor binding to oligonucleotides .
22934511	0	Diethylstilbestrol	1,19	LGR8	28,32	Diethylstilbestrol	LGR8	MESH:D004054	140498(Tax:10090)	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|expression expression|nummod|END_ENTITY	-LSB- Diethylstilbestrol affects LGR8 expression in mouse gubernaculum testis -RSB- .
26855023	0	Diethylstilbestrol	0,18	LGR8	47,51	Diethylstilbestrol	LGR8	MESH:D004054	140498(Tax:10090)	Chemical	Gene	Regulates|nsubj|START_ENTITY Regulates|dobj|Expression Expression|nmod|END_ENTITY	Diethylstilbestrol Regulates the Expression of LGR8 in Mouse Gubernaculum Testis Cells .
26457333	0	Diethylstilbestrol	85,103	Msx-2	33,38	Diethylstilbestrol	Msx-2	MESH:D004054	17702(Tax:10090)	Chemical	Gene	Response|nmod|START_ENTITY END_ENTITY|dobj|Response	Homeodomain Transcription Factor Msx-2 Regulates Uterine Progenitor Cell Response to Diethylstilbestrol .
9586949	0	Diferuloylmethane	10,27	tumor_necrosis_factor	43,64	Diferuloylmethane	tumor necrosis factor	MESH:D003474	7124	Chemical	Gene	inhibition|appos|START_ENTITY inhibition|nmod|END_ENTITY	Curcumin -LRB- Diferuloylmethane -RRB- inhibition of tumor_necrosis_factor -LRB- TNF -RRB- - mediated adhesion of monocytes to endothelial cells by suppression of cell surface expression of adhesion molecules and of nuclear factor-kappaB activation .
25191940	0	Difluoro-dioxolo-benzoimidazol-benzamides	0,41	CK1	66,69	Difluoro-dioxolo-benzoimidazol-benzamides	CK1	null	122011	Chemical	Gene	START_ENTITY|nmod|Inhibitors Inhibitors|nmod|END_ENTITY	Difluoro-dioxolo-benzoimidazol-benzamides As Potent Inhibitors of CK1 and with Nanomolar Inhibitory Activity on Cancer Cell Proliferation .
26247418	0	Difluorosialic_acids	0,20	neuraminidase	51,64	Difluorosialic acids	neuraminidase	null	4758	Chemical	Gene	START_ENTITY|appos|inhibitors inhibitors|compound|END_ENTITY	Difluorosialic_acids , potent novel influenza virus neuraminidase inhibitors , induce fewer drug resistance-associated neuraminidase mutations than does oseltamivir .
21139994	0	Digitoxin	0,9	EGR1	20,24	Digitoxin	EGR1	MESH:D004074	1958	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Digitoxin activates EGR1 and synergizes with paclitaxel on human breast_cancer cells .
19020076	0	Digoxin	0,7	HIF-1alpha	45,55	Digoxin	HIF-1alpha	MESH:D004077	3091	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|synthesis synthesis|compound|END_ENTITY	Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth .
20065104	0	Digoxin	0,7	HIF-1alpha	42,52	Digoxin	HIF-1alpha	MESH:D004077	15251(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Digoxin inhibits retinal_ischemia-induced HIF-1alpha expression and ocular_neovascularization .
26514315	0	Digoxin	51,58	P-Glycoprotein	62,76	Digoxin	P-Glycoprotein	MESH:D004077	5243	Chemical	Gene	START_ENTITY|appos|Substrate Substrate|compound|END_ENTITY	Effects of Fostamatinib on the Pharmacokinetics of Digoxin -LRB- a P-Glycoprotein Substrate -RRB- : Results From in Vitro and Phase I Clinical Studies .
6991446	0	Digoxin	0,7	renin	26,31	Digoxin	renin	MESH:D004077	5972	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	Digoxin without effect on renin release in healthy subjects .
2572425	0	Dihydrexidine	0,13	dopamine_D-1_receptor	51,72	Dihydrexidine	dopamine D-1 receptor	MESH:C061532	1812	Chemical	Gene	potency|advmod|START_ENTITY potency|dobj|agonist agonist|amod|END_ENTITY	Dihydrexidine , a novel selective high potency full dopamine_D-1_receptor agonist .
15492773	0	Dihydrexidine	0,13	dopamine_D1_receptor	30,50	Dihydrexidine	dopamine D1 receptor	MESH:C061532	1812	Chemical	Gene	START_ENTITY|dep|agonist agonist|amod|END_ENTITY	Dihydrexidine -- the first full dopamine_D1_receptor agonist .
8100195	0	Dihydrexidine	0,13	dopamine_D1_receptor	39,59	Dihydrexidine	dopamine D1 receptor	MESH:C061532	1812	Chemical	Gene	START_ENTITY|dep|agonist agonist|amod|END_ENTITY	Dihydrexidine : a new potent peripheral dopamine_D1_receptor agonist .
26545100	0	Dihydroagarofuranoid_Sesquiterpenes	0,35	Acetylcholinesterase	39,59	Dihydroagarofuranoid Sesquiterpenes	Acetylcholinesterase	null	43	Chemical	Gene	START_ENTITY|nmod|Inhibitors Inhibitors|compound|END_ENTITY	Dihydroagarofuranoid_Sesquiterpenes as Acetylcholinesterase Inhibitors from Celastraceae Plants : Maytenus disticha and Euonymus japonicus .
26784960	0	Dihydroartemisinin	0,18	STAT3	33,38	Dihydroartemisinin	STAT3	MESH:C039060	6774	Chemical	Gene	START_ENTITY|nmod|Inhibitor Inhibitor|compound|END_ENTITY	Dihydroartemisinin as a Putative STAT3 Inhibitor , Suppresses the Growth of Head_and_Neck_Squamous_Cell_Carcinoma by Targeting Jak2/STAT3 Signaling .
25027631	0	Dihydroartemisinin	0,18	Toll-like_receptor_4	46,66	Dihydroartemisinin	Toll-like receptor 4	MESH:C039060	21898(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	Dihydroartemisinin inhibits activation of the Toll-like_receptor_4 signaling pathway and production of type I interferon in spleen cells from lupus-prone MRL/lpr mice .
25482945	0	Dihydroartemisinin	0,18	VEGFR2	27,33	Dihydroartemisinin	VEGFR2	MESH:C039060	16542(Tax:10090)	Chemical	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Dihydroartemisinin targets VEGFR2 via the NF-kB pathway in endothelial cells to inhibit angiogenesis .
18822958	0	Dihydroartemisinin	1,19	transferrin_receptor	53,73	Dihydroartemisinin	transferrin receptor	MESH:C039060	7037	Chemical	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|nmod|END_ENTITY	-LSB- Dihydroartemisinin down-regulates the expression of transferrin_receptor in myeloid_leukemia cells -RSB- .
16075280	0	Dihydroartemisinin	0,18	vascular_endothelial_growth_factor	33,67	Dihydroartemisinin	vascular endothelial growth factor	MESH:C039060	7422	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|compound|END_ENTITY	Dihydroartemisinin downregulates vascular_endothelial_growth_factor expression and induces apoptosis in chronic_myeloid_leukemia K562 cells .
16499092	0	Dihydroartemisinin	1,19	vascular_endothelial_growth_factor	47,81	Dihydroartemisinin	vascular endothelial growth factor	MESH:C039060	7422	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	-LSB- Dihydroartemisinin inhibits the expression of vascular_endothelial_growth_factor in K562 cells -RSB- .
16926633	0	Dihydroartemisinin	0,18	vascular_endothelial_growth_factor	131,165	Dihydroartemisinin	vascular endothelial growth factor	MESH:C039060	7422	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|angiogenesis angiogenesis|acl|induced induced|nmod|conditions conditions|nmod|downregulation downregulation|nmod|expression expression|compound|END_ENTITY	Dihydroartemisinin inhibits angiogenesis induced by multiple_myeloma RPMI8226 cells under hypoxic conditions via downregulation of vascular_endothelial_growth_factor expression and suppression of vascular_endothelial_growth_factor secretion .
16926633	0	Dihydroartemisinin	0,18	vascular_endothelial_growth_factor	196,230	Dihydroartemisinin	vascular endothelial growth factor	MESH:C039060	7422	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|angiogenesis angiogenesis|acl|induced induced|nmod|conditions conditions|nmod|downregulation downregulation|nmod|secretion secretion|compound|END_ENTITY	Dihydroartemisinin inhibits angiogenesis induced by multiple_myeloma RPMI8226 cells under hypoxic conditions via downregulation of vascular_endothelial_growth_factor expression and suppression of vascular_endothelial_growth_factor secretion .
7586928	0	Dihydrocodeine	0,14	CYP2D6	59,65	Dihydrocodeine	CYP2D6	MESH:C014481	1565	Chemical	Gene	START_ENTITY|dep|substrate substrate|nmod|END_ENTITY	Dihydrocodeine : a new opioid substrate for the polymorphic CYP2D6 in humans .
17727612	0	Dihydrodipicolinate	0,19	CRR1	44,48	Dihydrodipicolinate	CRR1	CHEBI:14148	835286(Tax:3702)	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Dihydrodipicolinate reductase-like protein , CRR1 , is essential for chloroplast NAD -LRB- P -RRB- H dehydrogenase in Arabidopsis .
1663596	0	Dihydroergotamine	0,17	CGRP	54,58	Dihydroergotamine	CGRP	MESH:D004087	24241(Tax:10116)	Chemical	Gene	levels|amod|START_ENTITY levels|nmod|END_ENTITY	Dihydroergotamine and sumatriptan attenuate levels of CGRP in plasma in rat superior sagittal sinus during electrical stimulation of the trigeminal ganglion .
26368530	0	Dihydrolipoamide	28,44	Lpd	60,63	Dihydrolipoamide	Lpd	MESH:C007409	65059	Chemical	Gene	Dehydrogenase|compound|START_ENTITY Dehydrogenase|appos|END_ENTITY	Pseudomonas_aeruginosa Uses Dihydrolipoamide Dehydrogenase -LRB- Lpd -RRB- to Bind to the Human Terminal Pathway Regulators Vitronectin and Clusterin to Inhibit Terminal Pathway Complement Attack .
26054747	0	Dihydromyricetin	0,16	irisin	28,34	Dihydromyricetin	irisin	MESH:C472036	252995	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|compound|END_ENTITY	Dihydromyricetin stimulates irisin secretion partially via the PGC-1a pathway .
25026750	0	Dihydropirymidine	1,18	DPD	34,37	Dihydropirymidine	DPD	null	1806	Chemical	Gene	dehydrogenase|compound|START_ENTITY dehydrogenase|appos|END_ENTITY	-LSB- Dihydropirymidine dehydrogenase -LRB- DPD -RRB- -- a toxicity marker for 5-fluorouracil ? -RSB- .
20349157	0	Dihydroprogesterone	0,19	myelin_basic_protein	53,73	Dihydroprogesterone	myelin basic protein	MESH:D004092	24547(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Dihydroprogesterone increases the gene expression of myelin_basic_protein in spinal cord of diabetic rats .
26985285	0	Dihydropteridinone	0,18	BRD4	33,37	Dihydropteridinone	BRD4	null	23476	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|nmod|END_ENTITY	Dihydropteridinone Inhibitors of BRD4 .
21252456	0	Dihydropteroate	0,15	DHPS	26,30	Dihydropteroate	DHPS	MESH:C000978	1725	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	Dihydropteroate synthase -LRB- DHPS -RRB- gene mutation study in HIV-Infected Indian patients with Pneumocystis jirovecii pneumonia .
2164016	0	Dihydropyridine	0,15	acetylcholinesterase	39,59	Dihydropyridine	acetylcholinesterase	MESH:C038806	43	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Dihydropyridine receptor regulation of acetylcholinesterase biosynthesis .
26460788	0	Dihydropyridinone	16,33	P2X7_Receptor	34,47	Dihydropyridinone	P2X7 Receptor	null	5027	Chemical	Gene	Antagonists|compound|START_ENTITY Antagonists|compound|END_ENTITY	Novel Series of Dihydropyridinone P2X7_Receptor Antagonists .
22306127	0	Dihydropyrimidine	0,17	DPD	33,36	Dihydropyrimidine	DPD	null	1806	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|dep|END_ENTITY	Dihydropyrimidine dehydrogenase -LRB- DPD -RRB- expression is negatively regulated by certain microRNAs in human lung tissues .
26022839	0	Dihydropyrrolopyrazol-6-one	0,27	MCHR1	28,33	Dihydropyrrolopyrazol-6-one	MCHR1	null	2847	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|compound|END_ENTITY	Dihydropyrrolopyrazol-6-one MCHR1 antagonists for the treatment of obesity : Insights on in vivo efficacy from a novel FLIPR assay setup .
16539403	0	Dihydropyrrolopyrazole	0,22	transforming_growth_factor-beta_type_I_receptor	23,70	Dihydropyrrolopyrazole	transforming growth factor-beta type I receptor	null	7046	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Dihydropyrrolopyrazole transforming_growth_factor-beta_type_I_receptor kinase domain inhibitors : a novel benzimidazole series with selectivity versus transforming growth factor-beta type II receptor kinase and mixed_lineage_kinase-7 .
16278291	0	Dihydrosphingosine_1-phosphate	0,30	MMP1	42,46	Dihydrosphingosine 1-phosphate	MMP1	MESH:C060504	4312	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	Dihydrosphingosine_1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets 1 pathway in human fibroblasts .
26282490	0	Dihydrotanshinone_I	0,19	hypoxia-inducible_factor-1a	61,88	Dihydrotanshinone I	hypoxia-inducible factor-1a	null	3091	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Dihydrotanshinone_I inhibits the translational expression of hypoxia-inducible_factor-1a .
6218182	0	Dihydrotestosterone	0,19	5_alpha-reductase	31,48	Dihydrotestosterone	5 alpha-reductase	MESH:D013196	6715	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|amod|END_ENTITY	Dihydrotestosterone stimulates 5_alpha-reductase activity in pubic skin fibroblasts .
19729001	0	Dihydrotestosterone	0,19	CREB	30,34	Dihydrotestosterone	CREB	MESH:D013196	81646(Tax:10116)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Dihydrotestosterone activates CREB signaling in cultured hippocampal neurons .
23153363	0	Dihydrotestosterone	0,19	SREBP-1	28,35	Dihydrotestosterone	SREBP-1	MESH:D013196	6720	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Dihydrotestosterone induces SREBP-1 expression and lipogenesis through the phosphoinositide 3-kinase/Akt pathway in HaCaT cells .
10913783	0	Dihydrotestosterone	0,19	androgen-receptor	57,74	Dihydrotestosterone	androgen-receptor	MESH:D013196	24208(Tax:10116)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Dihydrotestosterone and estrogen regulation of rat brain androgen-receptor immunoreactivity .
18547308	0	Dihydrotestosterone	0,19	androgen_receptor	56,73	Dihydrotestosterone	androgen receptor	MESH:D013196	11835(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|growth growth|nmod|END_ENTITY	Dihydrotestosterone inhibits murine hair growth via the androgen_receptor .
20103743	0	Dihydrotestosterone	0,19	cyclooxygenase-2	27,43	Dihydrotestosterone	cyclooxygenase-2	MESH:D013196	5743	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|levels levels|amod|END_ENTITY	Dihydrotestosterone alters cyclooxygenase-2 levels in human coronary artery smooth muscle cells .
19040620	0	Dihydrotestosterone	0,19	gonadotropin-releasing_hormone	40,70	Dihydrotestosterone	gonadotropin-releasing hormone	MESH:D013196	2796	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|amod|END_ENTITY	Dihydrotestosterone and leptin regulate gonadotropin-releasing_hormone -LRB- GnRH -RRB- expression and secretion in human GnRH-secreting neuroblasts .
22040886	0	Dihydrotestosterone	0,19	interleukin-1a	29,43	Dihydrotestosterone	interleukin-1a	MESH:D013196	3552	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Dihydrotestosterone inhibits interleukin-1a or tumor_necrosis_factor a-induced proinflammatory cytokine production via androgen_receptor-dependent inhibition of nuclear factor-kB activation in rheumatoid fibroblast-like synovial cell line .
21503567	0	Dihydrotestosterone	0,19	p27	28,31	Dihydrotestosterone	p27	MESH:D013196	10534	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|degradation degradation|amod|END_ENTITY	Dihydrotestosterone induces p27 degradation via direct binding with SKP2 in ovarian_and_breast_cancer .
11836106	0	Dihydroxybergamottin_caproate	0,29	CYP3A4	53,59	Dihydroxybergamottin caproate	CYP3A4	null	1576	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|compound|END_ENTITY	Dihydroxybergamottin_caproate as a potent and stable CYP3A4 inhibitor .
16524888	0	Dihydroxyphenylethanol	0,22	PP2A	92,96	Dihydroxyphenylethanol	PP2A	null	5524	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|activating activating|dobj|END_ENTITY	Dihydroxyphenylethanol induces apoptosis by activating serine/threonine protein phosphatase PP2A and promotes the endoplasmic reticulum stress response in human colon_carcinoma cells .
25542144	0	Diindolylmethane	0,16	CYP3A4	58,64	Diindolylmethane	CYP3A4	MESH:C444299	1576	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Diindolylmethane , a naturally occurring compound , induces CYP3A4 and MDR1 gene expression by activating human PXR .
25542144	0	Diindolylmethane	0,16	PXR	110,113	Diindolylmethane	PXR	MESH:C444299	8856	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|activating activating|dobj|END_ENTITY	Diindolylmethane , a naturally occurring compound , induces CYP3A4 and MDR1 gene expression by activating human PXR .
12186818	0	Diisocyanate	0,12	monocyte_chemoattractant_protein-1	32,66	Diisocyanate	monocyte chemoattractant protein-1	CHEBI:53213	6347	Chemical	Gene	synthesis|amod|START_ENTITY synthesis|amod|END_ENTITY	Diisocyanate antigen-stimulated monocyte_chemoattractant_protein-1 synthesis has greater test efficiency than specific antibodies for identification of diisocyanate asthma .
9723671	0	Diisocyanate	0,12	monocyte_chemoattractant_protein-1	44,78	Diisocyanate	monocyte chemoattractant protein-1	CHEBI:53213	6347	Chemical	Gene	START_ENTITY|dobj|production production|nmod|END_ENTITY	Diisocyanate antigen-enhanced production of monocyte_chemoattractant_protein-1 , IL-8 , and tumor_necrosis_factor-alpha by peripheral mononuclear cells of workers with occupational_asthma .
24865588	0	Diisopropylamine_dichloroacetate	0,32	pyruvate_dehydrogenase_kinase_4	42,73	Diisopropylamine dichloroacetate	pyruvate dehydrogenase kinase 4	MESH:C001002	27273(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Diisopropylamine_dichloroacetate , a novel pyruvate_dehydrogenase_kinase_4 inhibitor , as a potential therapeutic agent for metabolic_disorders and multiorgan_failure in severe influenza .
1645120	0	Diisopropylfluorophosphate	0,26	acetylcholinesterase	36,56	Diisopropylfluorophosphate	acetylcholinesterase	MESH:D007531	114549(Tax:7955)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Diisopropylfluorophosphate inhibits acetylcholinesterase activity and disrupts somitogenesis in the zebrafish .
1673267	0	Diisopropylfluorophosphate	0,26	prolactin	47,56	Diisopropylfluorophosphate	prolactin	MESH:D007531	24683(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	Diisopropylfluorophosphate -LRB- DFP -RRB- reduces serum prolactin , thyrotropin , luteinizing hormone , and growth_hormone and increases adrenocorticotropin and corticosterone in rats : involvement of dopaminergic and somatostatinergic as well as cholinergic pathways .
11174004	0	Dilazep_hydrochloride	0,21	IL-6	102,106	Dilazep hydrochloride	IL-6	null	16193(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|compound|END_ENTITY	Dilazep_hydrochloride , an antiplatelet drug , inhibits lipopolysaccharide-induced mouse mesangial cell IL-6 secretion and proliferation .
21494320	0	Dileucine	12,21	Organic_Anion_Transporter_1	62,89	Dileucine	Organic Anion Transporter 1	null	9356	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	The Role of Dileucine in the Expression and Function of Human Organic_Anion_Transporter_1 -LRB- hOAT1 -RRB- .
11689017	0	Dilinoleoylphosphatidylcholine	0,30	cytochrome_P4502E1	57,75	Dilinoleoylphosphatidylcholine	cytochrome P4502E1	MESH:C002448	25086(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|END_ENTITY	Dilinoleoylphosphatidylcholine decreases ethanol-induced cytochrome_P4502E1 .
20336709	0	Dilinoleoylphosphatidylcholine	0,30	heme_oxygenase-1	79,95	Dilinoleoylphosphatidylcholine	heme oxygenase-1	MESH:C002448	547612(Tax:3847)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Dilinoleoylphosphatidylcholine induces the expression of the anti-inflammatory heme_oxygenase-1 in RAW264 .7 macrophages .
1907699	0	Diltiazem	0,9	IL-2	19,23	Diltiazem	IL-2	MESH:D004110	16183(Tax:10090)	Chemical	Gene	restores|nsubj|START_ENTITY restores|dobj|END_ENTITY	Diltiazem restores IL-2 , IL-3 , IL-6 , and IFN-gamma synthesis and decreases host susceptibility to sepsis following hemorrhage .
15801939	0	Diltiazem	0,9	cytochrome_P450_3A	36,54	Diltiazem	cytochrome P450 3A	MESH:D004110	1576	Chemical	Gene	inhibits|advmod|START_ENTITY inhibits|nsubj|END_ENTITY	Diltiazem inhibits human intestinal cytochrome_P450_3A -LRB- CYP3A -RRB- activity in vivo without altering the expression of intestinal mRNA or protein .
11605028	0	Diltiazem	0,9	matrix_metalloproteinase-1	42,68	Diltiazem	matrix metalloproteinase-1	MESH:D004110	4312	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Diltiazem , a calcium antagonist , inhibits matrix_metalloproteinase-1 -LRB- tissue collagenase -RRB- production and collagenolytic activity in human vascular smooth muscle cells .
2432398	0	Diltiazem	0,9	transferrin_receptor	19,39	Diltiazem	transferrin receptor	MESH:D004110	7037	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Diltiazem inhibits transferrin_receptor expression and causes G1 arrest in normal and neoplastic_T cells .
26797869	0	Dimethoate	75,85	Acetylcholinesterase	33,53	Dimethoate	Acetylcholinesterase	MESH:D004117	43	Chemical	Gene	Resistance|compound|START_ENTITY Aphis|nmod|Resistance Aphis|nsubj|Mutations Mutations|nmod|Associated Associated|compound|END_ENTITY	Multiple Mutations on the Second Acetylcholinesterase Gene Associated With Dimethoate Resistance in the Melon Aphid , Aphis gossypii -LRB- Hemiptera : Aphididae -RRB- .
18725288	0	Dimethoxyaurones	0,16	ABCG2	39,44	Dimethoxyaurones	ABCG2	null	9429	Chemical	Gene	START_ENTITY|dep|inhibitors inhibitors|nmod|END_ENTITY	Dimethoxyaurones : Potent inhibitors of ABCG2 -LRB- breast_cancer_resistance_protein -RRB- .
19177192	0	Dimethoxycurcumin	0,17	Heme_Oxygenase-1	58,74	Dimethoxycurcumin	Heme Oxygenase-1	MESH:C521105	3162	Chemical	Gene	Induces|nsubj|START_ENTITY Induces|dobj|Expression Expression|compound|END_ENTITY	Dimethoxycurcumin , a Synthetic Curcumin Analogue , Induces Heme_Oxygenase-1 Expression through Nrf2 Activation in RAW264 .7 Macrophages .
19177192	0	Dimethoxycurcumin	0,17	Nrf2	94,98	Dimethoxycurcumin	Nrf2	MESH:C521105	4780	Chemical	Gene	Induces|nsubj|START_ENTITY Induces|nmod|Activation Activation|compound|END_ENTITY	Dimethoxycurcumin , a Synthetic Curcumin Analogue , Induces Heme_Oxygenase-1 Expression through Nrf2 Activation in RAW264 .7 Macrophages .
25839861	0	Dimethyl_Fumarate	51,68	PML	0,3	Dimethyl Fumarate	PML	MESH:C056020	5371	Chemical	Gene	Treated|nmod|START_ENTITY END_ENTITY|nmod|Treated	PML in a Patient with Lymphocytopenia Treated with Dimethyl_Fumarate .
26244324	0	Dimethyl_Fumarate	29,46	PML	0,3	Dimethyl Fumarate	PML	MESH:C056020	5371	Chemical	Gene	Treated|nmod|START_ENTITY Treated|nsubj|END_ENTITY	PML in Patients Treated with Dimethyl_Fumarate .
26244324	0	Dimethyl_Fumarate	29,46	PML	0,3	Dimethyl Fumarate	PML	MESH:C056020	5371	Chemical	Gene	Treated|nmod|START_ENTITY Treated|nsubj|END_ENTITY	PML in Patients Treated with Dimethyl_Fumarate .
26244325	0	Dimethyl_Fumarate	29,46	PML	0,3	Dimethyl Fumarate	PML	MESH:C056020	5371	Chemical	Gene	Treated|nmod|START_ENTITY Treated|nsubj|END_ENTITY	PML in Patients Treated with Dimethyl_Fumarate .
26244326	0	Dimethyl_Fumarate	29,46	PML	0,3	Dimethyl Fumarate	PML	MESH:C056020	5371	Chemical	Gene	Treated|nmod|START_ENTITY Treated|nsubj|END_ENTITY	PML in Patients Treated with Dimethyl_Fumarate .
26244326	0	Dimethyl_Fumarate	29,46	PML	0,3	Dimethyl Fumarate	PML	MESH:C056020	5371	Chemical	Gene	Treated|nmod|START_ENTITY Treated|nsubj|END_ENTITY	PML in Patients Treated with Dimethyl_Fumarate .
26789899	0	Dimethyl_Fumarate	37,54	PML	8,11	Dimethyl Fumarate	PML	MESH:C056020	5371	Chemical	Gene	More|nmod|START_ENTITY More|nmod|END_ENTITY	More on PML in Patients Treated with Dimethyl_Fumarate .
26789900	0	Dimethyl_Fumarate	37,54	PML	8,11	Dimethyl Fumarate	PML	MESH:C056020	5371	Chemical	Gene	More|nmod|START_ENTITY More|nmod|END_ENTITY	More on PML in Patients Treated with Dimethyl_Fumarate .
26798867	0	Dimethyl_Fumarate	37,54	PML	8,11	Dimethyl Fumarate	PML	MESH:C056020	5371	Chemical	Gene	More|nmod|START_ENTITY More|nmod|END_ENTITY	More on PML in Patients Treated with Dimethyl_Fumarate .
26582046	0	Dimethyl_Sulfoxide	0,18	Insulin	93,100	Dimethyl Sulfoxide	Insulin	MESH:D004121	3630	Chemical	Gene	Destabilization|compound|START_ENTITY Destabilization|nmod|Monitored Monitored|compound|END_ENTITY	Dimethyl_Sulfoxide Induced Destabilization and Disassembly of Various Structural Variants of Insulin Fibrils Monitored by Vibrational Circular Dichroism .
24569076	0	Dimethyl_fumarate	0,17	HIF-1a	87,93	Dimethyl fumarate	HIF-1a	MESH:C056020	15251(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Dimethyl_fumarate inhibits the expression and function of hypoxia-inducible factor-1a -LRB- HIF-1a -RRB- .
11444834	0	Dimethyl_sulfide	0,16	tyrosinase	80,90	Dimethyl sulfide	tyrosinase	MESH:C004784	7299	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Dimethyl_sulfide , a volatile flavor constituent , is a slow-binding inhibitor of tyrosinase .
8039880	0	Dimethyl_sulfoxide	0,18	NF-kappa_B	29,39	Dimethyl sulfoxide	NF-kappa B	MESH:D004121	18033(Tax:10090)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activation activation|amod|END_ENTITY	Dimethyl_sulfoxide modulates NF-kappa_B and cytokine activation in lipopolysaccharide-treated murine macrophages .
6704158	0	Dimethyl_sulfoxide	0,18	acetylcholinesterase	34,54	Dimethyl sulfoxide	acetylcholinesterase	MESH:D004121	43	Chemical	Gene	START_ENTITY|dep|inhibition inhibition|nmod|END_ENTITY	Dimethyl_sulfoxide : inhibition of acetylcholinesterase in the mammalian heart .
6294827	0	Dimethyl_sulfoxide	0,18	epidermal_growth_factor_receptor	76,108	Dimethyl sulfoxide	epidermal growth factor receptor	MESH:D004121	24329(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Dimethyl_sulfoxide stimulates tyrosine residue phosphorylation of rat liver epidermal_growth_factor_receptor .
21533649	0	Dimethyl_sulfoxide	0,18	heme_oxygenase-1	27,43	Dimethyl sulfoxide	heme oxygenase-1	MESH:D004121	3162	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Dimethyl_sulfoxide induces heme_oxygenase-1 expression via JNKs and Nrf2 pathways in human umbilical vein endothelial cells .
24415199	0	Dimethyl_sulfoxide	0,18	heme_oxygenase-1	85,101	Dimethyl sulfoxide	heme oxygenase-1	MESH:D004121	3162	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|injury_in_cardiomyocytes injury_in_cardiomyocytes|nmod|END_ENTITY	Dimethyl_sulfoxide attenuates hydrogen_peroxide-induced injury_in_cardiomyocytes via heme_oxygenase-1 .
15135155	0	Dimethylaminopurine	0,19	insulin	50,57	Dimethylaminopurine	insulin	MESH:C001020	3630	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|effects effects|nmod|END_ENTITY	Dimethylaminopurine inhibits metabolic effects of insulin in primary adipocytes .
17292729	0	Dimethylarginines	0,17	insulin	38,45	Dimethylarginines	insulin	null	3630	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	Dimethylarginines at the crossroad of insulin resistance and atherosclerosis .
20688046	0	Dimethylcelecoxib	0,17	mPGES-1	27,34	Dimethylcelecoxib	mPGES-1	null	64292(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Dimethylcelecoxib inhibits mPGES-1 promoter activity by influencing EGR1 and NF-kB .
11886496	0	Dimethylfumarate	0,16	CD62E	56,61	Dimethylfumarate	CD62E	MESH:C056020	6401	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Dimethylfumarate inhibits tumor-necrosis-factor-induced CD62E expression in an NF-kappa_B-dependent manner .
22790915	0	Dimethylfumarate	0,16	CXCL10	26,32	Dimethylfumarate	CXCL10	MESH:C056020	3627	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Dimethylfumarate inhibits CXCL10 via haem oxygenase-1 in airway smooth muscle .
9168952	0	Dimethylfumarate	0,16	VCAM-1	65,71	Dimethylfumarate	VCAM-1	MESH:C056020	7412	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Dimethylfumarate is an inhibitor of cytokine-induced E-selectin , VCAM-1 , and ICAM-1 expression in human endothelial cells .
21788833	0	Dimethyloxalylglycine	0,21	HIF-1a	33,39	Dimethyloxalylglycine	HIF-1a	null	3091	Chemical	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	Dimethyloxalylglycine stabilizes HIF-1a in cultured human endothelial cells and increases random-pattern skin flap survival in vivo .
23959549	0	Diminazene_aceturate	0,20	angiotensin-converting_enzyme_2	30,61	Diminazene aceturate	angiotensin-converting enzyme 2	MESH:C003915	302668(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|amod|END_ENTITY	Diminazene_aceturate enhances angiotensin-converting_enzyme_2 activity and attenuates_ischemia-induced cardiac pathophysiology .
26300056	0	Dinaciclib	0,10	ABCB1	73,78	Dinaciclib	ABCB1	MESH:C553669	5243	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Dinaciclib , a cyclin-dependent kinase inhibitor , is a substrate of human ABCB1 and ABCG2 and an inhibitor of human ABCC1 in vitro .
26876677	0	Dioctanoyl_Glycerate	34,54	Trypsin_Inhibitor	72,89	Dioctanoyl Glycerate	Trypsin Inhibitor	null	83716	Chemical	Gene	Synthesis|nmod|START_ENTITY Synthesis|nmod|END_ENTITY	Synthesis and Characterization of Dioctanoyl_Glycerate as Water-soluble Trypsin_Inhibitor .
2022306	0	Dioctanoylglycerol	0,18	Ca2	43,46	Dioctanoylglycerol	Ca2	null	760	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Dioctanoylglycerol regulation of cytosolic Ca2 + by protein_kinase_C-independent mechanism in HIT T-15 islet cells .
9927381	0	Dioleylphosphatidylglycerol	0,27	type_II_phospholipase_A2	55,79	Dioleylphosphatidylglycerol	type II phospholipase A2	null	100135599(Tax:10141)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Dioleylphosphatidylglycerol inhibits the expression of type_II_phospholipase_A2 in macrophages .
24680847	0	Dioscin	0,7	MDR1	60,64	Dioscin	MDR1	MESH:C019357	5243	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Dioscin enhances methotrexate absorption by down-regulating MDR1 in vitro and in vivo .
23107741	0	Dioscin	0,7	tyrosinase	23,33	Dioscin	tyrosinase	MESH:C019357	7299	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Dioscin : a synergistic tyrosinase inhibitor from the roots of Smilax china .
22461009	0	Diosgenin	0,9	ERK1/2	102,108	Diosgenin	ERK1/2	MESH:D004144	50689;116590	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Diosgenin promotes oligodendrocyte progenitor cell differentiation through estrogen receptor-mediated ERK1/2 activation to accelerate remyelination .
20053498	0	Diosgenin	0,9	STAT3	41,46	Diosgenin	STAT3	MESH:D004144	6774	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Diosgenin , a steroidal_saponin , inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular_carcinoma cells .
25429088	0	Diosgenin	0,9	TM4	25,28	Diosgenin	TM4	MESH:D004144	24852(Tax:10116)	Chemical	Gene	Proliferation|compound|START_ENTITY Proliferation|compound|END_ENTITY	Diosgenin Stimulates Rat TM4 Cell Proliferation Through Activating Plasma Membrane Translocation and Transcriptional Activity of Estrogen Receptors .
24377630	0	Diosgenin	0,9	hTERT	19,24	Diosgenin	hTERT	MESH:D004144	7015	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Diosgenin inhibits hTERT gene expression in the A549_lung_cancer cell line .
23419394	0	Diosmin	0,7	TNF-a	106,111	Diosmin	TNF-a	MESH:D004145	24835(Tax:10116)	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|hepatic_injury_via_alleviation_of_inflammation hepatic_injury_via_alleviation_of_inflammation|nmod|activation activation|amod|END_ENTITY	Diosmin protects against ethanol-induced hepatic_injury_via_alleviation_of_inflammation and regulation of TNF-a and NF-kB activation .
8831761	0	Dioxabicyclooctanyl_naphthalenenitriles	0,39	5-lipoxygenase	52,66	Dioxabicyclooctanyl naphthalenenitriles	5-lipoxygenase	null	240	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Dioxabicyclooctanyl_naphthalenenitriles as nonredox 5-lipoxygenase inhibitors : structure-activity relationship study directed toward the improvement of metabolic stability .
14684744	0	Dioxin	0,6	C/EBPbeta	17,26	Dioxin	C/EBPbeta	CHEBI:28119	12608(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|transcription transcription|compound|END_ENTITY	Dioxin increases C/EBPbeta transcription by activating cAMP/protein kinase A .
24243026	0	Dioxin	0,6	acetylcholinesterase	42,62	Dioxin	acetylcholinesterase	CHEBI:28119	43	Chemical	Gene	compounds|compound|START_ENTITY suppress|nsubj|compounds suppress|dobj|activity activity|amod|END_ENTITY	Dioxin and dioxin-like compounds suppress acetylcholinesterase activity via transcriptional downregulations in vitro .
2033054	0	Dioxin	0,6	transforming_growth_factor-alpha	15,47	Dioxin	transforming growth factor-alpha	CHEBI:28119	7124	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Dioxin induces transforming_growth_factor-alpha in human keratinocytes .
26577067	0	Dioxygen	0,8	JMJD2A	59,65	Dioxygen	JMJD2A	MESH:D010100	9682	Chemical	Gene	Binding|compound|START_ENTITY Binding|nmod|END_ENTITY	Dioxygen Binding in the Active Site of Histone Demethylase JMJD2A and the Role of the Protein Environment .
26663343	0	Dioxygen	0,8	JMJD2A	59,65	Dioxygen	JMJD2A	MESH:D010100	9682	Chemical	Gene	Binding|compound|START_ENTITY Binding|nmod|END_ENTITY	Dioxygen Binding in the Active Site of Histone Demethylase JMJD2A and the Role of the Protein Environment .
18278872	0	Dioxygen	0,8	cystathionine_beta-synthase	64,91	Dioxygen	cystathionine beta-synthase	MESH:D010100	875	Chemical	Gene	reactivity|amod|START_ENTITY reactivity|nmod|END_ENTITY	Dioxygen reactivity and heme redox potential of truncated human cystathionine_beta-synthase .
572704	0	Dioxygen	0,8	myoglobin	33,42	Dioxygen	myoglobin	MESH:D010100	4151	Chemical	Gene	reaction|compound|START_ENTITY reaction|nmod|END_ENTITY	Dioxygen replacement reaction in myoglobin .
2115332	0	Dipalmitoylphosphatidylcholine	0,30	phospholipase_A2	61,77	Dipalmitoylphosphatidylcholine	phospholipase A2	MESH:D015060	151056	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|amod|END_ENTITY	Dipalmitoylphosphatidylcholine -LRB- L-alpha-lecithin -RRB- stimulates phospholipase_A2 activity in human amnion .
19422802	0	Dipentamethylene_thiuram_monosulfide	0,36	Pin1	61,65	Dipentamethylene thiuram monosulfide	Pin1	MESH:C541134	5300	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Dipentamethylene_thiuram_monosulfide is a novel inhibitor of Pin1 .
26083974	0	Dipeptide	40,49	Tyrosinase	69,79	Dipeptide	Tyrosinase	CHEBI:46761	7299	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|nmod|END_ENTITY	Discovery of Potent Cysteine-Containing Dipeptide Inhibitors against Tyrosinase : A Comprehensive Investigation of 20 * 20 Dipeptides in Inhibiting Dopachrome Formation .
14980679	0	Dipeptidyl_aspartyl_fluoromethylketones	0,39	caspase-3	50,59	Dipeptidyl aspartyl fluoromethylketones	caspase-3	null	836	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Dipeptidyl_aspartyl_fluoromethylketones as potent caspase-3 inhibitors : SAR of the P2 amino_acid .
19515558	0	Dipeptidyl_nitrile	0,18	Cathepsin_L	33,44	Dipeptidyl nitrile	Cathepsin L	null	1514	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Dipeptidyl_nitrile inhibitors of Cathepsin_L .
21558882	0	Diphenyl_diselenide	0,19	LDLr	67,71	Diphenyl diselenide	LDLr	MESH:C061132	16835(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|nmod|END_ENTITY	Diphenyl_diselenide effectively reduces atherosclerotic_lesions in LDLr - / - mice by attenuation of oxidative stress and inflammation .
16970403	0	Diphenyl_phosphonate	0,20	urokinase-type_plasminogen_activator	40,76	Diphenyl phosphonate	urokinase-type plasminogen activator	null	5328	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Diphenyl_phosphonate inhibitors for the urokinase-type_plasminogen_activator : optimization of the P4 position .
22403640	0	Diphenyl_urea	0,13	transketolase	43,56	Diphenyl urea	transketolase	CHEBI:41320	7086	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|inhibitors inhibitors|nmod|END_ENTITY	Diphenyl_urea derivatives as inhibitors of transketolase : a structure-based virtual screening .
22493432	0	Diphenylarsinic_acid	0,20	Lon_protease	76,88	Diphenylarsinic acid	Lon protease	MESH:C493087	9361	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Diphenylarsinic_acid promotes degradation of glutaminase_C by mitochondrial Lon_protease .
17184774	0	Diphenyleneiodonium	0,19	p53	44,47	Diphenyleneiodonium	p53	MESH:C007517	7157	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Diphenyleneiodonium induces ROS-independent p53 expression and apoptosis in human RPE cells .
22650305	0	Diphenylpyridylethanamine	0,25	CETP	84,88	Diphenylpyridylethanamine	CETP	null	1071	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Diphenylpyridylethanamine -LRB- DPPE -RRB- derivatives as cholesteryl_ester transfer protein -LRB- CETP -RRB- inhibitors .
17334477	0	Diphereline	67,78	gonadotropin-releasing_hormone	28,58	Diphereline	gonadotropin-releasing hormone	null	2796	Chemical	Gene	analog|appos|START_ENTITY analog|amod|END_ENTITY	Comparison of the effect of gonadotropin-releasing_hormone analog -LRB- Diphereline -RRB- and Cabergoline -LRB- Dostinex -RRB- treatment on uterine_myoma regression .
22427771	0	Diphereline	63,74	gonadotropin-releasing_hormone	23,53	Diphereline	gonadotropin-releasing hormone	null	2796	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Half-dose , long-acting gonadotropin-releasing_hormone agonist -LRB- Diphereline -RRB- is comparable with daily injections of short-acting gonadotropin-releasing_hormone agonist -LRB- Suprefact -RRB- in IVF/ICSI cycles .
18765564	0	Diphthamide	0,11	eEF2	28,32	Diphthamide	eEF2	CHEBI:15949	13629(Tax:10090)	Chemical	Gene	modification|amod|START_ENTITY modification|nmod|END_ENTITY	Diphthamide modification of eEF2 requires a J-domain protein and is essential for normal development .
22869748	0	Diphthamide	0,11	eukaryotic_elongation_factor_2	28,58	Diphthamide	eukaryotic elongation factor 2	CHEBI:15949	13629(Tax:10090)	Chemical	Gene	modification|amod|START_ENTITY modification|nmod|END_ENTITY	Diphthamide modification on eukaryotic_elongation_factor_2 is needed to assure fidelity of mRNA translation and mouse development .
26253686	0	Dipotassium_glycyrrhizate	0,25	HMGB1	30,35	Dipotassium glycyrrhizate	HMGB1	null	15289(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|signaling signaling|compound|END_ENTITY	Dipotassium_glycyrrhizate via HMGB1 or AMPK signaling suppresses oxidative stress during intestinal_inflammation .
25894775	0	Diprotin_A	10,20	Dipeptidyl_Peptidase_IV	38,61	Diprotin A	Dipeptidyl Peptidase IV	MESH:C041445	1803	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|Inhibitor Inhibitor|nmod|END_ENTITY	Effect of Diprotin_A , an Inhibitor of Dipeptidyl_Peptidase_IV , on Immunological Parameters of Lymphocytes in Intact Animals and Animals with Experimental Autoimmune Process .
26670079	0	Diptoindonesin_G	63,79	ERa	25,28	Diptoindonesin G	ERa	MESH:C543798	26284	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|Stability Stability|compound|END_ENTITY	Reciprocal Regulation of ERa and ERb Stability and Activity by Diptoindonesin_G .
18435922	0	Dipyrithione	0,12	iNOS	49,53	Dipyrithione	iNOS	MESH:C032196	18126(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Dipyrithione inhibits lipopolysaccharide-induced iNOS and COX-2 up-regulation in macrophages and protects against endotoxic_shock in mice .
7774024	0	Disaccharides	0,13	endomannosidase	17,32	Disaccharides	endomannosidase	MESH:D004187	79694	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Disaccharides as endomannosidase inhibitors : syntheses of alpha-homomannojirimycin and beta-homomannojirimycin linked to D-glucose and D-mannose .
27020590	0	Discoidin_domain	0,16	DDR1	29,33	Discoidin domain	DDR1	null	780	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Discoidin_domain receptor 1 -LRB- DDR1 -RRB- , a promising biomarker , induces epithelial to mesenchymal transition in renal_cancer_cells .
20167483	0	Discovery_of_substituted_biphenyl_imidazoles	0,44	bombesin_receptor_subtype-3	69,96	Discovery of substituted biphenyl imidazoles	bombesin receptor subtype-3	null	680	Chemical	Gene	START_ENTITY|nmod|agonists agonists|amod|END_ENTITY	Discovery_of_substituted_biphenyl_imidazoles as potent , bioavailable bombesin_receptor_subtype-3 agonists .
16600855	0	Discrete	0,8	synaptotagmin_I	41,56	Discrete	synaptotagmin I	null	6857	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Discrete residues in the c -LRB- 2 -RRB- b domain of synaptotagmin_I independently specify endocytic rate and synaptic vesicle size .
5357024	0	Disequilibrium	0,14	triose_phosphate_isomerase	22,48	Disequilibrium	triose phosphate isomerase	null	500959(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|system system|amod|END_ENTITY	Disequilibrium in the triose_phosphate_isomerase system in rat liver .
25031598	0	Disodium_Hydrogen_Phosphate	106,133	BMP-2	137,142	Disodium Hydrogen Phosphate	BMP-2	CHEBI:34683	650	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|Production Production|compound|END_ENTITY	Effect of Mineral Trioxide Aggregate , Calcium-Enriched Mixture Cement and Mineral Trioxide Aggregate with Disodium_Hydrogen_Phosphate on BMP-2 Production .
4183038	0	Disodium_cromoglycate	0,21	phospholipase_A	95,110	Disodium cromoglycate	phospholipase A	MESH:D004205	57110	Chemical	Gene	induced|advmod|START_ENTITY induced|nmod|END_ENTITY	Disodium_cromoglycate , an inhibitor of mas cell degranulation and histamine release induced by phospholipase_A .
22821864	0	Disparate	0,9	Igf1	10,14	Disparate	Igf1	null	3479	Chemical	Gene	START_ENTITY|dobj|expression expression|amod|END_ENTITY	Disparate Igf1 expression and growth in the fore - and hind limbs of a marsupial mammal -LRB- Monodelphis_domestica -RRB- .
14575835	0	Disparate	0,9	endostatin	21,31	Disparate	endostatin	null	80781	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|END_ENTITY	Disparate effects of endostatin on tumor vascular perfusion and hypoxia in two murine mammary carcinomas .
8408651	0	Disparate	0,9	insulin	21,28	Disparate	insulin	null	100009181(Tax:9986)	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|END_ENTITY	Disparate effects of insulin on isolated rabbit afferent and efferent arterioles .
11594788	0	Disparate	0,9	interleukin_11	21,35	Disparate	interleukin 11	null	16156(Tax:10090)	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|END_ENTITY	Disparate effects of interleukin_11 and thrombopoietin on megakaryocytopoiesis in vitro .
2206128	0	Disparate	0,9	interleukin_4	114,127	Disparate	interleukin 4	null	3565	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Disparate regulation of interleukin_8 gene expression from blood monocytes , endothelial cells , and fibroblasts by interleukin_4 .
2206128	0	Disparate	0,9	interleukin_8	24,37	Disparate	interleukin 8	null	3576	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Disparate regulation of interleukin_8 gene expression from blood monocytes , endothelial cells , and fibroblasts by interleukin_4 .
2905268	0	Disparate	0,9	neuropeptide_Y	21,35	Disparate	neuropeptide Y	null	24604(Tax:10116)	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|END_ENTITY	Disparate effects of neuropeptide_Y and clonidine on the excretion of sodium and water in the rat .
3495589	0	Disparate	0,9	tumor_necrosis_factor-alpha	21,48	Disparate	tumor necrosis factor-alpha	null	7124	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|END_ENTITY	Disparate effects of tumor_necrosis_factor-alpha / cachectin and tumor_necrosis_factor-beta / lymphotoxin on hematopoietic_growth_factor production and neutrophil adhesion molecule expression by cultured human endothelial cells .
21040934	0	Dispo85E	152,160	HGF	165,168	Dispo85E	HGF	MESH:C559486	15234(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inducer inducer|compound|END_ENTITY	Hepatocyte_growth_factor has a role in the amelioration of diabetic_vascular_complications via autophagic clearance of advanced glycation end products : Dispo85E , an HGF inducer , as a potential botanical drug .
25568284	0	Disproportionate	0,16	Serotonin_Transporter	30,51	Disproportionate	Serotonin Transporter	null	6532	Chemical	Gene	Reduction|compound|START_ENTITY Reduction|nmod|END_ENTITY	Disproportionate Reduction of Serotonin_Transporter May Predict the Response and Adherence to Antidepressants in Patients with Major_Depressive_Disorder : A Positron Emission Tomography Study with 4 - -LSB- 18F -RSB- - ADAM .
7449767	0	Disproportionate	0,16	myosin	33,39	Disproportionate	myosin	null	79784	Chemical	Gene	accumulation|amod|START_ENTITY accumulation|nmod|END_ENTITY	Disproportionate accumulation of myosin and tropomyosin in cultured muscle cells .
8349412	1	Disulfide	63,72	BDNF	107,111	Disulfide	BDNF	CHEBI:48343	627	Chemical	Gene	structure|amod|START_ENTITY structure|nmod|END_ENTITY	Disulfide structure and characterization of BDNF expressed in CHO cells .
8437238	0	Disulfide	0,9	Nef	68,71	Disulfide	Nef	CHEBI:48343	156110(Tax:11676)	Chemical	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	Disulfide bond formation in the human_immunodeficiency_virus_type_1 Nef protein .
25697356	0	Disulfide	35,44	PDI	56,59	Disulfide	PDI	CHEBI:48343	64714	Chemical	Gene	Isomerase|compound|START_ENTITY Isomerase|appos|END_ENTITY	Proapoptotic Activities of Protein Disulfide Isomerase -LRB- PDI -RRB- and PDIA3 Protein , a Role of the Bcl-2 Protein Bak .
10604596	0	Disulfide	0,9	agouti-related_protein	56,78	Disulfide	agouti-related protein	CHEBI:48343	181	Chemical	Gene	assignment|amod|START_ENTITY assignment|nmod|knot knot|nmod|END_ENTITY	Disulfide assignment of the C-terminal cysteine knot of agouti-related_protein -LRB- AGRP -RRB- by direct sequencing analysis .
2403360	0	Disulfide	0,9	glia_maturation_factor_beta	34,61	Disulfide	glia maturation factor beta	CHEBI:48343	2764	Chemical	Gene	isoforms|amod|START_ENTITY isoforms|nmod|END_ENTITY	Disulfide isoforms of recombinant glia_maturation_factor_beta .
1328685	0	Disulfide	0,9	glycoprotein_D	28,42	Disulfide	glycoprotein D	CHEBI:48343	2532	Chemical	Gene	structure|amod|START_ENTITY structure|nmod|END_ENTITY	Disulfide bond structure of glycoprotein_D of herpes simplex virus types 1 and 2 .
2463792	0	Disulfide	0,9	granulocyte_colony_stimulating_factor	56,93	Disulfide	granulocyte colony stimulating factor	CHEBI:48343	1440	Chemical	Gene	structures|amod|START_ENTITY structures|nmod|END_ENTITY	Disulfide and secondary structures of recombinant human granulocyte_colony_stimulating_factor .
2472117	0	Disulfide	0,9	interleukin-6	30,43	Disulfide	interleukin-6	CHEBI:48343	3569	Chemical	Gene	structures|amod|START_ENTITY structures|nmod|END_ENTITY	Disulfide structures of human interleukin-6 are similar to those of human granulocyte_colony_stimulating_factor .
10066782	0	Disulfide	0,9	interleukin-6_receptor	92,114	Disulfide	interleukin-6 receptor	CHEBI:48343	3570	Chemical	Gene	structure|amod|START_ENTITY structure|nmod|END_ENTITY	Disulfide bond structure and N-glycosylation sites of the extracellular domain of the human interleukin-6_receptor .
24193513	0	Disulfiram	0,10	O6-methylguanine-DNA_methyltransferase	53,91	Disulfiram	O6-methylguanine-DNA methyltransferase	MESH:D004221	4255	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Disulfiram is a direct and potent inhibitor of human O6-methylguanine-DNA_methyltransferase -LRB- MGMT -RRB- in brain_tumor cells and mouse brain and markedly increases the alkylating DNA damage .
25937029	0	Disulfiram	0,10	O6-methylguanine-DNA_methyltransferase	76,114	Disulfiram	O6-methylguanine-DNA methyltransferase	MESH:D004221	4255	Chemical	Gene	sensitizes|nsubj|START_ENTITY sensitizes|xcomp|temozolomide temozolomide|advcl|regulating regulating|dobj|expression expression|compound|END_ENTITY	Disulfiram sensitizes pituitary_adenoma cells to temozolomide by regulating O6-methylguanine-DNA_methyltransferase expression .
17579916	0	Disulfiram	0,10	monoacylglycerol_lipase	45,68	Disulfiram	monoacylglycerol lipase	MESH:D004221	11343	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Disulfiram is an inhibitor of human purified monoacylglycerol_lipase , the enzyme regulating 2-arachidonoylglycerol signaling .
1406260	0	Disulphide	0,10	beta-lactamase	66,80	Disulphide	beta-lactamase	null	7872529(Tax:562)	Chemical	Gene	formation|amod|START_ENTITY END_ENTITY|nsubj|formation	Disulphide bridge formation in the periplasm of Escherichia_coli : beta-lactamase : : human IgG3 hinge fusions as a model system .
1314883	0	Dithiocarbamates	0,16	nuclear_factor_kappa_B	41,63	Dithiocarbamates	nuclear factor kappa B	null	4790	Chemical	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Dithiocarbamates as potent inhibitors of nuclear_factor_kappa_B activation in intact cells .
9536450	0	Divalproex_sodium	0,17	growth_hormone	29,43	Divalproex sodium	growth hormone	MESH:D014635	2688	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|response response|amod|END_ENTITY	Divalproex_sodium attenuates growth_hormone response to baclofen in healthy human males .
16551428	0	Dobesilate	0,10	signal_transducer_and_activator_of_transcription_3	38,88	Dobesilate	signal transducer and activator of transcription 3	null	25125(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	Dobesilate inhibits the activation of signal_transducer_and_activator_of_transcription_3 , and the expression of cyclin_D1 and bcl-XL in glioma cells .
11288970	0	Dobutamine	0,10	angiotensin-converting_enzyme	24,53	Dobutamine	angiotensin-converting enzyme	MESH:D004280	1636	Chemical	Gene	START_ENTITY|nmod|therapy therapy|amod|END_ENTITY	Dobutamine as bridge to angiotensin-converting_enzyme inhibitor-nitrate therapy in endstage_heart_failure .
12818967	0	Dobutamine	0,10	monocyte_chemoattractant_protein-1	20,54	Dobutamine	monocyte chemoattractant protein-1	MESH:D004280	6347	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Dobutamine inhibits monocyte_chemoattractant_protein-1 production and chemotaxis in human monocytes .
17308071	5	Docetaxel	574,583	Bax	603,606	Docetaxel	Bax	MESH:C067311	581	Chemical	Gene	induced|compound|START_ENTITY changes|nsubj|induced changes|nmod|END_ENTITY	Docetaxel induced changes in Bax that correlated with sensitivity to docetaxel-induced apoptosis .
25683983	0	Docetaxel	109,118	Prostate-Specific_Antigen	20,45	Docetaxel	Prostate-Specific Antigen	MESH:C067311	354	Chemical	Gene	Chemotherapy|compound|START_ENTITY Flare|nmod|Chemotherapy Rise|nmod|Flare Rise|nmod|END_ENTITY	Exponential Rise in Prostate-Specific_Antigen -LRB- PSA -RRB- during Anti-Androgen Withdrawal Predicts PSA Flare after Docetaxel Chemotherapy in Patients with Castration-Resistant Prostate_Cancer .
21185827	0	Docetaxel	0,9	cyclooxygenase-2	19,35	Docetaxel	cyclooxygenase-2	MESH:C067311	29527(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|induction induction|amod|END_ENTITY	Docetaxel inhibits cyclooxygenase-2 induction in vascular smooth muscle cells .
21455255	0	Docetaxel	0,9	p53	63,66	Docetaxel	p53	MESH:C067311	7157	Chemical	Gene	START_ENTITY|dobj|injection injection|nmod|END_ENTITY	Docetaxel plus trans-tracheal injection of adenoviral-mediated p53 versus docetaxel alone in patients with previously treated non-small-cell_lung_cancer .
22445862	0	Docetaxel	0,9	p53	42,45	Docetaxel	p53	MESH:C067311	7157	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|transcription transcription|compound|END_ENTITY	Docetaxel and 5-fluorouracil induce human p53 tumor suppressor gene transcription via a short sequence at core promoter element .
15837994	0	Docetaxel	0,9	prostate-specific_antigen	69,94	Docetaxel	prostate-specific antigen	MESH:C067311	354	Chemical	Gene	followed|nsubj|START_ENTITY followed|nmod|men men|acl|experiencing experiencing|dobj|END_ENTITY	Docetaxel followed by hormone therapy in men experiencing increasing prostate-specific_antigen after primary local treatments for prostate_cancer .
21490806	0	Docosahexaenoic_Acid	69,89	Serum_Response_Factor	14,35	Docosahexaenoic Acid	Serum Response Factor	CHEBI:28125	6722	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of Serum_Response_Factor and Adiponectin by PPARy Agonist Docosahexaenoic_Acid .
19217763	0	Docosahexaenoic_acid	0,20	ACAT1	40,45	Docosahexaenoic acid	ACAT1	CHEBI:28125	38	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Docosahexaenoic_acid is a substrate for ACAT1 and inhibits cholesteryl_ester formation from oleic_acid in MCF-10A cells .
19737538	0	Docosahexaenoic_acid	0,20	Nox_4	48,53	Docosahexaenoic acid	Nox 4	CHEBI:28125	50507	Chemical	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|END_ENTITY	Docosahexaenoic_acid down-regulates endothelial Nox_4 through a sPLA2 signalling pathway .
19799960	0	Docosahexaenoic_acid	0,20	PPARalpha	106,115	Docosahexaenoic acid	PPARalpha	CHEBI:28125	19013(Tax:10090)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	Docosahexaenoic_acid modulates the expression of T-bet and GATA-3 transcription factors , independently of PPARalpha , through suppression of MAP kinase activation .
25044948	0	Docosahexaenoic_acid	0,20	PPARy	101,106	Docosahexaenoic acid	PPARy	CHEBI:28125	5468	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|nmod|END_ENTITY	Docosahexaenoic_acid reduces linoleic_acid induced monocyte_chemoattractant_protein-1 expression via PPARy and nuclear factor-kB pathway in retinal pigment epithelial cells .
25921297	0	Docosahexaenoic_acid	0,20	TNFa	44,48	Docosahexaenoic acid	TNFa	CHEBI:28125	21926(Tax:10090)	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|expression expression|compound|END_ENTITY	Docosahexaenoic_acid differentially affects TNFa and IL-6 expression in LPS-stimulated RAW 264.7 murine macrophages .
20573493	0	Docosahexaenoic_acid	0,20	VCAM-1	32,38	Docosahexaenoic acid	VCAM-1	CHEBI:28125	7412	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|compound|END_ENTITY	Docosahexaenoic_acid attenuates VCAM-1 expression and NF-kB activation in TNF-a-treated human aortic endothelial cells .
19571381	0	Docosahexaenoic_acid	0,20	adipose_differentiation-related_protein	29,68	Docosahexaenoic acid	adipose differentiation-related protein	CHEBI:28125	123	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Docosahexaenoic_acid induces adipose_differentiation-related_protein through activation of retinoid_x_receptor in human choriocarcinoma BeWo cells .
21653803	0	Docosahexaenoic_acid	0,20	apolipoprotein_A-I	32,50	Docosahexaenoic acid	apolipoprotein A-I	CHEBI:28125	335	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Docosahexaenoic_acid suppresses apolipoprotein_A-I gene expression through hepatocyte nuclear factor-3b .
17183061	0	Docosahexaenoic_acid	0,20	beta-catenin	65,77	Docosahexaenoic acid	beta-catenin	CHEBI:28125	1499	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|degradation degradation|nmod|END_ENTITY	Docosahexaenoic_acid induces proteasome-dependent degradation of beta-catenin , down-regulation of survivin and apoptosis in human colorectal_cancer cells not expressing COX-2 .
17192613	0	Docosahexaenoic_acid	0,20	choline_acetyltransferase	60,85	Docosahexaenoic acid	choline acetyltransferase	CHEBI:28125	12647(Tax:10090)	Chemical	Gene	supports|nsubj|START_ENTITY supports|dobj|growth growth|nmod|receptors receptors|amod|END_ENTITY	Docosahexaenoic_acid supports cell growth and expression of choline_acetyltransferase and muscarinic receptors in NG108-15 cell line .
18803253	0	Docosahexaenoic_acid	0,20	cytochrome_P450_2B1	57,76	Docosahexaenoic acid	cytochrome P450 2B1	CHEBI:28125	24300(Tax:10116)	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	Docosahexaenoic_acid downregulates phenobarbital-induced cytochrome_P450_2B1 gene expression in rat primary hepatocytes via the c-Jun_NH2-terminal_kinase mitogen-activated protein kinase pathway .
25044948	0	Docosahexaenoic_acid	0,20	monocyte_chemoattractant_protein-1	51,85	Docosahexaenoic acid	monocyte chemoattractant protein-1	CHEBI:28125	6347	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|amod|END_ENTITY	Docosahexaenoic_acid reduces linoleic_acid induced monocyte_chemoattractant_protein-1 expression via PPARy and nuclear factor-kB pathway in retinal pigment epithelial cells .
11082155	0	Docosahexaenoic_acid	0,20	peroxisome_proliferator-activated_receptor-alpha	24,72	Docosahexaenoic acid	peroxisome proliferator-activated receptor-alpha	CHEBI:28125	25747(Tax:10116)	Chemical	Gene	START_ENTITY|appos|ligand ligand|amod|END_ENTITY	Docosahexaenoic_acid , a peroxisome_proliferator-activated_receptor-alpha ligand , induces apoptosis in vascular smooth muscle cells by stimulation of p38 mitogen-activated protein kinase .
19571381	0	Docosahexaenoic_acid	0,20	retinoid_x_receptor	91,110	Docosahexaenoic acid	retinoid x receptor	CHEBI:28125	6256	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Docosahexaenoic_acid induces adipose_differentiation-related_protein through activation of retinoid_x_receptor in human choriocarcinoma BeWo cells .
19369048	0	Docosahexaenoic_acid	0,20	serum_amyloid_A_protein	31,54	Docosahexaenoic acid	serum amyloid A protein	CHEBI:28125	6288	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	Docosahexaenoic_acid regulates serum_amyloid_A_protein to promote lipolysis through down regulation of perilipin .
3622595	0	Domperidone	0,11	prolactin	107,116	Domperidone	prolactin	MESH:D004294	5617	Chemical	Gene	antagonizes|amod|START_ENTITY bromoergocriptine|amod|antagonizes bromoergocriptine|acl|induced induced|xcomp|nausea_and_vomiting nausea_and_vomiting|advcl|affecting affecting|dobj|inhibition inhibition|nmod|secretion secretion|compound|END_ENTITY	Domperidone antagonizes bromoergocriptine -- induced nausea_and_vomiting without affecting its inhibition of prolactin secretion in puerperal women .
9292204	0	Domperidone	0,11	prolactin	23,32	Domperidone	prolactin	MESH:D004294	24683(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|compound|END_ENTITY	Domperidone stimulates prolactin secretion in rats with complete destruction of the mediobasal_hypothalamus .
10849891	0	Donepezil	0,9	acetylcholinesterase	30,50	Donepezil	acetylcholinesterase	MESH:C076946	83817(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Donepezil , a centrally acting acetylcholinesterase inhibitor , alleviates learning_deficits in hypocholinergic models in rats .
18501884	0	Donepezil	0,9	acetylcholinesterase	14,34	Donepezil	acetylcholinesterase	MESH:C076946	83817(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Donepezil , an acetylcholinesterase inhibitor , enhances adult hippocampal neurogenesis .
20522977	0	Donepezil	0,9	acetylcholinesterase	20,40	Donepezil	acetylcholinesterase	MESH:C076946	43	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Donepezil , a potent acetylcholinesterase inhibitor , induces caspase-dependent apoptosis in human promyelocytic_leukemia HL-60 cells .
23231479	0	Donepezil	0,9	acetylcholinesterase	14,34	Donepezil	acetylcholinesterase	MESH:C076946	83817(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Donepezil , an acetylcholinesterase inhibitor , attenuates nicotine self-administration and reinstatement of nicotine seeking in rats .
8642415	0	Dopamine	0,8	5-HT2A	60,66	Dopamine	5-HT2A	MESH:D004298	29595(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY agonists|nsubj|receptor agonists|xcomp|regulate regulate|dobj|levels levels|nmod|receptor receptor|nummod|END_ENTITY	Dopamine receptor agonists regulate levels of the serotonin 5-HT2A receptor and its mRNA in a subpopulation of rat striatal neurons .
12388598	0	Dopamine	0,8	Akt	56,59	Dopamine	Akt	MESH:D004298	207	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|nmod|END_ENTITY	Dopamine induces a PI3-kinase-independent activation of Akt in striatal neurons : a new route to cAMP_response_element-binding_protein phosphorylation .
22065948	0	Dopamine	47,55	Akt	31,34	Dopamine	Akt	MESH:D004298	207	Chemical	Gene	Receptors|compound|START_ENTITY Regulation|nmod|Receptors Regulation|nmod|END_ENTITY	Beyond cAMP : The Regulation of Akt and GSK3 by Dopamine Receptors .
11338187	0	Dopamine	0,8	BDNF	54,58	Dopamine	BDNF	MESH:D004298	12064(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|appos|END_ENTITY	Dopamine regulates brain-derived_neurotrophic_factor -LRB- BDNF -RRB- expression in cultured embryonic mouse striatal cells .
22428025	0	Dopamine	0,8	BDNF	125,129	Dopamine	BDNF	MESH:D004298	627	Chemical	Gene	heteromer|amod|START_ENTITY heteromer|dep|regulation regulation|nmod|END_ENTITY	Dopamine D1-D2 receptor heteromer in dual phenotype GABA/glutamate-coexpressing striatal medium spiny neurons : regulation of BDNF , GAD67 and VGLUT1/2 .
22723051	0	Dopamine	0,8	BDNF	74,78	Dopamine	BDNF	MESH:D004298	627	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Dopamine induces LTP differentially in apical and basal dendrites through BDNF and voltage-dependent calcium channels .
19073433	0	Dopamine	0,8	Cdk2	77,81	Dopamine	Cdk2	MESH:D004298	12566(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|up-regulation up-regulation|amod|END_ENTITY	Dopamine induces supernumerary centrosomes and subsequent cell death through Cdk2 up-regulation in dopaminergic neuronal cells .
26656295	0	Dopamine	18,26	Chorein	0,7	Dopamine	Chorein	MESH:D004298	309243(Tax:10116)	Chemical	Gene	Release|compound|START_ENTITY Release|compound|END_ENTITY	Chorein Sensitive Dopamine Release from Pheochromocytoma -LRB- PC12 -RRB- Cells .
22581798	0	Dopamine	0,8	Cryptochrome	22,34	Dopamine	Cryptochrome	MESH:D004298	42305(Tax:7227)	Chemical	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	Dopamine acts through Cryptochrome to promote acute arousal in Drosophila .
2565360	0	Dopamine	0,8	D-2	9,12	Dopamine	D-2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|compound|END_ENTITY	Dopamine D-2 antagonists reverse apomorphine-induced decreased water intake in the rat : prediction of antipsychotic drugs with few extrapyramidal_side-effects ?
2893738	0	Dopamine	0,8	D-2	9,12	Dopamine	D-2	MESH:D004298	28503	Chemical	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	Dopamine D-2 receptors in canine brain : ionic effects on -LSB- 3H -RSB- neuroleptic binding .
2949991	0	Dopamine	0,8	D-2	59,62	Dopamine	D-2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	agonists|amod|START_ENTITY agonists|nmod|quinpirole quinpirole|compound|END_ENTITY	Dopamine D-1 receptor agonists combined with the selective D-2 agonist quinpirole facilitate the expression of oral stereotyped behaviour in rats .
11134516	0	Dopamine	0,8	D1/D5	9,14	Dopamine	D1/D5	MESH:D004298	25802	Chemical	Gene	modulation|compound|START_ENTITY modulation|compound|END_ENTITY	Dopamine D1/D5 receptor modulation of excitatory synaptic inputs to layer V prefrontal cortex neurons .
15689153	0	Dopamine	0,8	D1/D5	9,14	Dopamine	D1/D5	MESH:D004298	25802	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|compound|END_ENTITY	Dopamine D1/D5 receptor antagonists with improved pharmacokinetics : design , synthesis , and biological evaluation of phenol bioisosteric analogues of benzazepine D1/D5 antagonists .
10025578	0	Dopamine	0,8	D1_and_D2	9,18	Dopamine	D1 and D2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	agents|amod|START_ENTITY agents|amod|END_ENTITY	Dopamine D1_and_D2 receptor agents and their interaction influence the synaptic density of the rat prefrontal cortex .
1449252	0	Dopamine	0,8	D1_and_D2	9,18	Dopamine	D1 and D2	MESH:D004298	25802;28503	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Dopamine D1_and_D2 receptors in progressive_supranuclear_palsy : an autoradiographic study .
16023708	0	Dopamine	0,8	D1_and_D2	9,18	Dopamine	D1 and D2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|contributions contributions|amod|END_ENTITY	Dopamine D1_and_D2 receptor contributions to L-DOPA-induced_dyskinesia in the dopamine-depleted rat .
17184754	0	Dopamine	0,8	D1_and_D2	9,18	Dopamine	D1 and D2	MESH:D004298	25802;28503	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Dopamine D1_and_D2 receptors regulate extracellular lactate and glucose concentrations in the nucleus accumbens .
1829682	0	Dopamine	0,8	D1_and_D2	9,18	Dopamine	D1 and D2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Dopamine D1_and_D2 receptors mediate opposite functions in seizures induced by lithium-pilocarpine .
1968237	0	Dopamine	0,8	D1_and_D2	9,18	Dopamine	D1 and D2	MESH:D004298	13370(Tax:10090)	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Dopamine D1_and_D2 receptors mediate opposite effects of apomorphine on the body temperature of reserpinized mice .
20001111	0	Dopamine	0,8	D1_and_D2	9,18	Dopamine	D1 and D2	MESH:D004298	25802;28503	Chemical	Gene	START_ENTITY|dobj|effects effects|amod|END_ENTITY	Dopamine D1_and_D2 antagonist effects on response likelihood and duration .
2006243	0	Dopamine	0,8	D1_and_D2	9,18	Dopamine	D1 and D2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|mediation mediation|amod|END_ENTITY	Dopamine D1_and_D2 mediation of the discriminative stimulus properties of d-amphetamine and cocaine .
2961976	0	Dopamine	0,8	D1_and_D2	9,18	Dopamine	D1 and D2	MESH:D004298	25802;28503	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Dopamine D1_and_D2 receptors are sensitive to the cationic form of apomorphine .
7974202	0	Dopamine	0,8	D1_and_D2	77,86	Dopamine	D1 and D2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	displays|nsubj|START_ENTITY displays|dobj|affinity affinity|nmod|receptors receptors|amod|END_ENTITY	Dopamine displays an identical apparent affinity towards functional dopamine D1_and_D2 receptors in rat striatal slices : possible implications for the regulatory role of D2 receptors .
7886117	0	Dopamine	0,8	D1_and_D2_receptor	9,27	Dopamine	D1 and D2 receptor	MESH:D004298	13488;13489	Chemical	Gene	ligands|amod|START_ENTITY ligands|amod|END_ENTITY	Dopamine D1_and_D2_receptor ligands modulate the behaviour of mice in the elevated plus-maze .
20456009	0	Dopamine	0,8	D1_and_D3	9,18	Dopamine	D1 and D3	MESH:D004298	226695(Tax:10090)	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Dopamine D1_and_D3 receptors are differentially involved in cue-elicited cocaine seeking .
25429131	0	Dopamine	0,8	D1_and_D5	9,18	Dopamine	D1 and D5	MESH:D004298	13370(Tax:10090)	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Dopamine D1_and_D5 receptors modulate spike_timing-dependent_plasticity at medial perforant path to dentate granule cell synapses .
10890919	0	Dopamine	0,8	D1_and_adenosine_A1	9,28	Dopamine	D1 and adenosine A1	MESH:D004298	25802	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Dopamine D1_and_adenosine_A1 receptors form functionally interacting heteromeric complexes .
25073922	0	Dopamine	0,8	D1_and_corticotrophin_releasing_hormone	9,48	Dopamine	D1 and corticotrophin releasing hormone	MESH:D004298	25802	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Dopamine D1_and_corticotrophin_releasing_hormone type-2a receptors assemble into functionally interacting complexes in living cells .
11716810	0	Dopamine	0,8	D2	9,11	Dopamine	D2	MESH:D004298	28503	Chemical	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Dopamine D2 receptor-mediated G-protein activation in rat striatum : functional autoradiography and influence of unilateral 6-hydroxydopamine lesions of the substantia nigra .
9721018	0	Dopamine	0,8	D2_and_D4_receptor	9,27	Dopamine	D2 and D4 receptor	MESH:D004298	1815	Chemical	Gene	ligands|amod|START_ENTITY ligands|amod|END_ENTITY	Dopamine D2_and_D4_receptor ligands : relation to antipsychotic action .
12496946	0	Dopamine	0,8	D2_receptor	24,35	Dopamine	D2 receptor	MESH:D004298	13489(Tax:10090)	Chemical	Gene	D1|compound|START_ENTITY D1|nmod|END_ENTITY	Dopamine D1 rather than D2_receptor agonists disrupt prepulse inhibition of startle in mice .
26446938	0	Dopamine	0,8	D2_receptor	64,75	Dopamine	D2 receptor	MESH:D004298	1813	Chemical	Gene	binds|nsubj|START_ENTITY binds|nmod|autoregulation autoregulation|nmod|END_ENTITY	Dopamine binds calmodulin during autoregulation of dopaminergic D2_receptor signaling through CaMKIIa-calmodulin complex .
1352429	0	Dopamine	0,8	DA1	9,12	Dopamine	DA1	MESH:D004298	294269(Tax:10116)	Chemical	Gene	agonist|compound|START_ENTITY agonist|compound|END_ENTITY	Dopamine DA1 receptor agonist , fenoldopam , reverses glycine-induced hyperfiltration in rats .
2707038	0	Dopamine	0,8	DA1	79,82	Dopamine	DA1	MESH:D004298	294269(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|dep|characterization characterization|nmod|sites sites|compound|END_ENTITY	Dopamine receptors in rabbit and rat eye : characterization and localization of DA1 and DA2 binding sites .
7906663	0	Dopamine	0,8	DA1	9,12	Dopamine	DA1	MESH:D004298	294269(Tax:10116)	Chemical	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Dopamine DA1 receptor activation reduces experimentally-induced gastritis in rats .
8092305	0	Dopamine	0,8	DA1	9,12	Dopamine	DA1	MESH:D004298	294269(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	Dopamine DA1 receptors on vascular smooth muscle cells are regulated by glucocorticoid and sodium_chloride .
23185343	0	Dopamine	0,8	DAT	104,107	Dopamine	DAT	MESH:D004298	6531	Chemical	Gene	D1|compound|START_ENTITY D1|appos|END_ENTITY	Dopamine D1 , D2 , D3 receptors , vesicular_monoamine_transporter_type-2 -LRB- VMAT2 -RRB- and dopamine_transporter -LRB- DAT -RRB- densities in aged human brain .
25402186	0	Dopamine	25,33	DAT	47,50	Dopamine	DAT	MESH:D004298	6531	Chemical	Gene	Transporter|compound|START_ENTITY Transporter|appos|END_ENTITY	Presence and Function of Dopamine Transporter -LRB- DAT -RRB- in Stallion Sperm : Dopamine Modulates Sperm Motility and Acrosomal Integrity .
25402186	0	Dopamine	71,79	DAT	47,50	Dopamine	DAT	MESH:D004298	6531	Chemical	Gene	Motility|compound|START_ENTITY Presence|dep|Motility Presence|nmod|Transporter Transporter|appos|END_ENTITY	Presence and Function of Dopamine Transporter -LRB- DAT -RRB- in Stallion Sperm : Dopamine Modulates Sperm Motility and Acrosomal Integrity .
26783754	0	Dopamine	0,8	DAT	122,125	Dopamine	DAT	MESH:D004298	6531	Chemical	Gene	START_ENTITY|dep|Differences Differences|nmod|Predicted Predicted|nmod|Interactions Interactions|nmod|END_ENTITY	Dopamine and the Creative Mind : Individual Differences in Creativity Are Predicted by Interactions between Dopamine Genes DAT and COMT .
26793549	0	Dopamine	4,12	DAT	26,29	Dopamine	DAT	MESH:D004298	6531	Chemical	Gene	Depletion|compound|START_ENTITY Depletion|nmod|Scan Scan|compound|END_ENTITY	Can Dopamine Depletion at DAT Scan in a Non Parkinson Patient be the Cause a Refractory Overactive Bladder ?
23905040	1	Dopamine	150,158	DRD1	159,163	Dopamine	DRD1	MESH:D004298	1812	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Dopamine DRD1 receptor regulates renal function and vascular resistance .
11765615	0	Dopamine	1,9	DRD2	25,29	Dopamine	DRD2	MESH:D004298	1813	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	-LSB- Dopamine receptor gene -LRB- DRD2 -RRB- polymorphism in patients with endogenous psychoses with regard to their clinical heterogeneity -RSB- .
12151753	0	Dopamine	0,8	DRD2	9,13	Dopamine	DRD2	MESH:D004298	1813	Chemical	Gene	I|compound|START_ENTITY I|compound|END_ENTITY	Dopamine DRD2 Taq I polymorphism associates with caudate nucleus volume and cognitive performance in memory_impaired subjects .
15492764	0	Dopamine	0,8	DRD2	18,22	Dopamine	DRD2	MESH:D004298	1813	Chemical	Gene	START_ENTITY|dobj|genotype genotype|compound|END_ENTITY	Dopamine receptor DRD2 genotype and smoking cessation outcome following treatment with bupropion_SR .
16085504	0	Dopamine	0,8	DRD2	19,23	Dopamine	DRD2	MESH:D004298	1813	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Dopamine receptor -LRB- DRD2 -RRB- genotype-dependent effects of nicotine on attention and distraction during rapid visual information processing .
19321766	0	Dopamine	0,8	DRD2	9,13	Dopamine	DRD2	MESH:D004298	1813	Chemical	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	Dopamine DRD2 polymorphism alters reversal learning and associated neural activity .
25415204	0	Dopamine	40,48	DRD2	64,68	Dopamine	DRD2	MESH:D004298	1813	Chemical	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Suicidal Behavior and Haplotypes of the Dopamine Receptor Gene -LRB- DRD2 -RRB- and ANKK1 Gene Polymorphisms in Patients with Alcohol Dependence - Preliminary Report .
25941120	0	Dopamine	4,12	DRD2	39,43	Dopamine	DRD2	MESH:D004298	1813	Chemical	Gene	Polymorphism|compound|START_ENTITY Polymorphism|appos|TaqIA TaqIA|compound|END_ENTITY	The Dopamine D2 Receptor Polymorphism -LRB- DRD2 TaqIA -RRB- Interacts with Maternal Parenting in Predicting Early Adolescent Depressive Symptoms : Evidence of Differential Susceptibility and Age Differences .
11673801	0	Dopamine	0,8	DRD3	22,26	Dopamine	DRD3	MESH:D004298	1814	Chemical	Gene	D3_receptor|amod|START_ENTITY associated|nsubjpass|D3_receptor associated|dep|END_ENTITY	Dopamine D3_receptor -LRB- DRD3 -RRB- gene polymorphism is associated with the intensity of eye movement_disturbances in schizophrenic patients and healthy subjects .
17407504	0	Dopamine	0,8	DRD3	31,35	Dopamine	DRD3	MESH:D004298	1814	Chemical	Gene	genes|amod|START_ENTITY genes|appos|DRD2 DRD2|dep|END_ENTITY	Dopamine receptor genes -LRB- DRD2 , DRD3 and DRD4 -RRB- and gene-gene interactions associated with smoking-related behaviors .
20236178	0	Dopamine	0,8	DRD3	21,25	Dopamine	DRD3	MESH:D004298	1814	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Dopamine receptor 3 -LRB- DRD3 -RRB- polymorphism and risk for migraine .
21963356	0	Dopamine	0,8	DRD3	18,22	Dopamine	DRD3	MESH:D004298	1814	Chemical	Gene	codes|amod|START_ENTITY codes|compound|END_ENTITY	Dopamine receptor DRD3 codes for trait aggression as Mendelian recessive .
23113067	0	Dopamine	32,40	DRD3	41,45	Dopamine	DRD3	MESH:D004298	1814	Chemical	Gene	Polymorphism|compound|START_ENTITY Polymorphism|compound|END_ENTITY	Genetic Association Analysis of Dopamine DRD3 Ser9Gly Polymorphism and Schizophrenia in Malay Population .
15662148	0	Dopamine	0,8	DRD4	21,25	Dopamine	DRD4	MESH:D004298	1815	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Dopamine receptor 4 -LRB- DRD4 -RRB- 7-repeat allele predicts methylphenidate dose response in children with attention_deficit_hyperactivity_disorder : a pharmacogenetic study .
26174753	0	Dopamine	0,8	DRD4	18,22	Dopamine	DRD4	MESH:D004298	1815	Chemical	Gene	START_ENTITY|dobj|gene gene|compound|END_ENTITY	Dopamine receptor DRD4 gene and stressful life events in persistent attention deficit hyperactivity disorder .
9011752	0	Dopamine	0,8	Dat	22,25	Dopamine	Dat	MESH:D004298	6531	Chemical	Gene	START_ENTITY|dobj|transporter transporter|appos|END_ENTITY	Dopamine transporter -LRB- Dat -RRB- and synaptic vesicle amine transporter -LRB- VMAT2 -RRB- gene expression in the substantia nigra of control and Parkinson 's _ disease .
26645629	0	Dopamine	24,32	Dopamine_D2_Receptor	85,105	Dopamine	Dopamine D2 Receptor	MESH:D004298	1813	Chemical	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Binding Interactions of Dopamine and Apomorphine in D2High and D2Low States of Human Dopamine_D2_Receptor Using Computational and Experimental Techniques .
19685014	0	Dopamine	0,8	GLT1	63,67	Dopamine	GLT1	MESH:D004298	6506	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Dopamine regulates the expression of the glutamate transporter GLT1 but not GLAST in developing striatal astrocytes .
25220264	0	Dopamine	115,123	Monoamine_Oxidase_B	71,90	Dopamine	Monoamine Oxidase B	MESH:D004298	4129	Chemical	Gene	Simulations|nmod|START_ENTITY Simulations|nmod|Metabolism Metabolism|compound|END_ENTITY	Empirical Valence Bond Simulations of the Hydride Transfer Step in the Monoamine_Oxidase_B Catalyzed Metabolism of Dopamine .
27010708	0	Dopamine	109,117	Monoamine_Oxidase_B	62,81	Dopamine	Monoamine Oxidase B	MESH:D004298	4129	Chemical	Gene	Decomposition|nmod|START_ENTITY Decomposition|compound|END_ENTITY	Path Integral Simulation of the H/D Kinetic Isotope Effect in Monoamine_Oxidase_B Catalyzed Decomposition of Dopamine .
14633135	0	Dopamine	0,8	NHE3	58,62	Dopamine	NHE3	MESH:D004298	105243(Tax:10090)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|protein protein|compound|END_ENTITY	Dopamine acutely decreases apical membrane Na/H exchanger NHE3 protein in mouse renal proximal tubule .
10595790	0	Dopamine	0,8	PTH	45,48	Dopamine	PTH	MESH:D004298	24694(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|effect effect|nmod|END_ENTITY	Dopamine enhances the phosphaturic effect of PTH during acute respiratory_alkalosis .
11941158	0	Dopamine	12,20	Prolactin	40,49	Dopamine	Prolactin	MESH:D004298	5617	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|Release Release|compound|END_ENTITY	The Role of Dopamine in Seizure-Induced Prolactin Release in Humans .
26132331	0	Dopamine	42,50	Prolactin	11,20	Dopamine	Prolactin	MESH:D004298	19109(Tax:10090)	Chemical	Gene	Neurones|compound|START_ENTITY Effects|nmod|Neurones Effects|nmod|END_ENTITY	Effects of Prolactin and Lactation on A15 Dopamine Neurones in the Rostral Preoptic Area of Female Mice .
26132331	0	Dopamine	42,50	Prolactin	11,20	Dopamine	Prolactin	MESH:D004298	19109(Tax:10090)	Chemical	Gene	Neurones|compound|START_ENTITY Effects|nmod|Neurones Effects|nmod|END_ENTITY	Effects of Prolactin and Lactation on A15 Dopamine Neurones in the Rostral Preoptic Area of Female Mice .
15090051	0	Dopamine	0,8	RGS2	41,45	Dopamine	RGS2	MESH:D004298	84583(Tax:10116)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|mRNA mRNA|compound|END_ENTITY	Dopamine receptor-mediated regulation of RGS2 and RGS4 mRNA differentially depends on ascending dopamine projections and time .
25212851	0	Dopamine	0,8	SLC6A3	21,27	Dopamine	SLC6A3	MESH:D004298	6531	Chemical	Gene	genotype|amod|START_ENTITY genotype|compound|END_ENTITY	Dopamine transporter SLC6A3 genotype affects cortico-striatal activity of set-shifts in Parkinson 's _ disease .
21552197	0	Dopamine	0,8	TNF-alpha	58,67	Dopamine	TNF-alpha	MESH:D004298	21926(Tax:10090)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Dopamine selectively modulates lipopolysaccharide-induced TNF-alpha , IFN-gamma and IL-10 within mice tissues .
17921876	0	Dopamine	0,8	TNFalpha	17,25	Dopamine	TNFalpha	MESH:D004298	7124	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Dopamine induces TNFalpha and TNF-R1 expression in SH-SY5Y human neuroblastoma cells .
19116261	0	Dopamine	0,8	UDP-glucuronosyltransferase_1A10	72,104	Dopamine	UDP-glucuronosyltransferase 1A10	MESH:D004298	54575	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Dopamine is a low-affinity and high-specificity substrate for the human UDP-glucuronosyltransferase_1A10 .
8868304	0	Dopamine	0,8	VIP	38,41	Dopamine	VIP	MESH:D004298	117064(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|release release|nmod|END_ENTITY	Dopamine inhibits in vitro release of VIP and proliferation of VIP-immunoreactive pituitary cells .
18720517	0	Dopamine	0,8	VMAT2	76,81	Dopamine	VMAT2	MESH:D004298	25549(Tax:10116)	Chemical	Gene	striatal|amod|START_ENTITY striatal|dep|11C 11C|dep|sensitive sensitive|nsubj|binding binding|compound|END_ENTITY	Dopamine modulating drugs influence striatal -LRB- + -RRB- - -LSB- 11C -RSB- DTBZ binding in rats : VMAT2 binding is sensitive to changes in vesicular dopamine concentration .
26203154	0	Dopamine	9,17	VPS35	0,5	Dopamine	VPS35	MESH:D004298	65114(Tax:10090)	Chemical	Gene	Neurons|compound|START_ENTITY END_ENTITY|nmod|Neurons	VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a , a Receptor of Chaperone-Mediated Autophagy That Is Critical for a-Synuclein Degradation and Prevention of Pathogenesis of Parkinson 's _ Disease .
26203154	0	Dopamine	9,17	VPS35	0,5	Dopamine	VPS35	MESH:D004298	65114(Tax:10090)	Chemical	Gene	Neurons|compound|START_ENTITY END_ENTITY|nmod|Neurons	VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a , a Receptor of Chaperone-Mediated Autophagy That Is Critical for a-Synuclein Degradation and Prevention of Pathogenesis of Parkinson 's _ Disease .
20303975	0	Dopamine	0,8	alkaline_phosphatase	36,56	Dopamine	alkaline phosphatase	MESH:D004298	43671(Tax:7227)	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Dopamine down-regulates activity of alkaline_phosphatase in Drosophila : the role of D2-like receptors .
3009325	0	Dopamine	0,8	angiotensin_II	55,69	Dopamine	angiotensin II	MESH:D004298	183	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Dopamine selectively inhibits aldosterone responses to angiotensin_II in humans .
3467880	0	Dopamine	0,8	angiotensin_II	48,62	Dopamine	angiotensin II	MESH:D004298	24179(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|nmod|END_ENTITY	Dopamine attenuates the contractile response to angiotensin_II in isolated rat glomeruli and cultured mesangial cells .
3882312	0	Dopamine	0,8	angiotensin_II	70,84	Dopamine	angiotensin II	MESH:D004298	183	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|nmod|END_ENTITY	Dopamine reduces aldosterone and 18-hydroxycorticosterone response to angiotensin_II in patients with essential low-renin hypertension and idiopathic_hyperaldosteronism .
6100739	0	Dopamine	0,8	angiotensin_II	55,69	Dopamine	angiotensin II	MESH:D004298	183	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Dopamine selectively inhibits aldosterone responses to angiotensin_II in man .
6373591	0	Dopamine	0,8	angiotensin_II	61,75	Dopamine	angiotensin II	MESH:D004298	183	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	Dopamine modulates sodium-dependent aldosterone responses to angiotensin_II in humans .
8386474	0	Dopamine	0,8	angiotensin_II	36,50	Dopamine	angiotensin II	MESH:D004298	183	Chemical	Gene	antagonizes|nsubj|START_ENTITY antagonizes|dobj|actions actions|nmod|END_ENTITY	Dopamine antagonizes the actions of angiotensin_II in renal brush-border membrane .
8675685	0	Dopamine	0,8	angiotensin_II	40,54	Dopamine	angiotensin II	MESH:D004298	24179(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|nmod|receptors receptors|compound|END_ENTITY	Dopamine decreases expression of type-1 angiotensin_II receptors in renal proximal tubule .
3158789	0	Dopamine	0,8	atrial_natriuretic_factor	66,91	Dopamine	atrial natriuretic factor	MESH:D004298	24602(Tax:10116)	Chemical	Gene	antagonists|amod|START_ENTITY inhibit|nsubj|antagonists inhibit|nmod|END_ENTITY	Dopamine receptor antagonists inhibit the natriuretic response to atrial_natriuretic_factor -LRB- ANF -RRB- .
11338187	0	Dopamine	0,8	brain-derived_neurotrophic_factor	19,52	Dopamine	brain-derived neurotrophic factor	MESH:D004298	12064(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Dopamine regulates brain-derived_neurotrophic_factor -LRB- BDNF -RRB- expression in cultured embryonic mouse striatal cells .
19295451	0	Dopamine	0,8	brain-derived_neurotrophic_factor	45,78	Dopamine	brain-derived neurotrophic factor	MESH:D004298	24225(Tax:10116)	Chemical	Gene	activation|amod|START_ENTITY induces|nsubj|activation induces|dobj|expression expression|amod|END_ENTITY	Dopamine D1-like receptor activation induces brain-derived_neurotrophic_factor protein expression .
15763138	0	Dopamine	0,8	c-Fos	50,55	Dopamine	c-Fos	MESH:D004298	2353	Chemical	Gene	production|amod|START_ENTITY production|amod|END_ENTITY	Dopamine and norepinephrine_transporter-dependent c-Fos production in vitro : relevance to neuroadaptation .
8361339	0	Dopamine	0,8	carboxypeptidase_E	42,60	Dopamine	carboxypeptidase E	MESH:D004298	25669(Tax:10116)	Chemical	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	Dopamine antagonist haloperidol increases carboxypeptidase_E mRNA in rat neurointermediate pituitary but not in various other rat tissues .
19017537	0	Dopamine	0,8	clock	51,56	Dopamine	clock	MESH:D004298	12753(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|regulation regulation|nmod|expression expression|compound|END_ENTITY	Dopamine receptor-mediated regulation of neuronal `` clock '' gene expression .
9016916	0	Dopamine	0,8	dopamine_D3_receptor	110,130	Dopamine	dopamine D3 receptor	MESH:D004298	29238(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY involved|nsubjpass|receptors involved|nmod|drugs drugs|dep|comparison comparison|nmod|GR103691 GR103691|amod|END_ENTITY	Dopamine D3 receptors are not involved in the induction of c-fos mRNA by neuroleptic drugs : comparison of the dopamine_D3_receptor antagonist GR103691 with typical and atypical neuroleptics .
2296581	0	Dopamine	0,8	enkephalin	37,47	Dopamine	enkephalin	MESH:D004298	29237(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Dopamine receptor gene expression by enkephalin neurons in rat forebrain .
8487949	0	Dopamine	0,8	enkephalin	28,38	Dopamine	enkephalin	MESH:D004298	29237(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|turnover turnover|compound|END_ENTITY	Dopamine decreases striatal enkephalin turnover and proenkephalin messenger RNA abundance via D2 receptor activation in primary striatal cell cultures .
22027511	0	Dopamine	0,8	epidermal_growth_factor	20,43	Dopamine	epidermal growth factor	MESH:D004298	1950	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|compound|END_ENTITY	Dopamine stimulates epidermal_growth_factor release from adult neural precursor cells derived from the subventricular zone by a disintegrin and metalloprotease .
7908600	0	Dopamine	0,8	fos	41,44	Dopamine	fos	MESH:D004298	314322(Tax:10116)	Chemical	Gene	control|compound|START_ENTITY control|nmod|expression expression|compound|END_ENTITY	Dopamine D2 receptor control of pallidal fos expression : comparisons between intact and 6-hydroxydopamine-treated hemispheres .
1491791	0	Dopamine	0,8	gonadotropin-releasing_hormone	23,53	Dopamine	gonadotropin-releasing hormone	MESH:D004298	25194(Tax:10116)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Dopamine regulation of gonadotropin-releasing_hormone -LRB- GnRH -RRB- gene expression in the female rat brain .
8284103	0	Dopamine	0,8	growth_hormone	18,32	Dopamine	growth hormone	MESH:D004298	2688	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|compound|END_ENTITY	Dopamine inhibits growth_hormone and prolactin secretion in the human newborn .
9359974	0	Dopamine	0,8	growth_hormone	52,66	Dopamine	growth hormone	MESH:D004298	2688	Chemical	Gene	function|amod|START_ENTITY function|dep|response response|amod|END_ENTITY	Dopamine function in obsessive-compulsive_disorder : growth_hormone response to apomorphine stimulation .
11115065	0	Dopamine	0,8	heme_oxygenase-1	35,51	Dopamine	heme oxygenase-1	MESH:D004298	3162	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Dopamine induces the expression of heme_oxygenase-1 by human endothelial cells in vitro .
24888351	0	Dopamine	0,8	insulin_receptor	134,150	Dopamine	insulin receptor	MESH:D004298	24954(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY inhibit|nsubj|receptors inhibit|dobj|proliferation proliferation|nmod|cells cells|acl|induced induced|nmod|insulin insulin|nmod|down-regulation down-regulation|nmod|expression expression|compound|END_ENTITY	Dopamine D receptors inhibit proliferation and migration of vascular smooth muscle cells induced by insulin via down-regulation of insulin_receptor expression .
8664982	0	Dopamine	0,8	interleukin_6	19,32	Dopamine	interleukin 6	MESH:D004298	24498(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|release release|amod|END_ENTITY	Dopamine increases interleukin_6 release and inhibits tumor_necrosis_factor release from rat adrenal zona glomerulosa cells in vitro .
8813364	0	Dopamine	0,8	monoamine_oxidase	56,73	Dopamine	monoamine oxidase	MESH:D004298	29253(Tax:10116)	Chemical	Gene	degraded|nsubjpass|START_ENTITY degraded|nmod|END_ENTITY	Dopamine produced from L-DOPA is degraded by endogenous monoamine_oxidase in neurons of the dorsal raphe nucleus of the rat : an immunohistochemical study .
10095083	0	Dopamine	0,8	neurotensin	35,46	Dopamine	neurotensin	MESH:D004298	4922	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|mRNA mRNA|compound|END_ENTITY	Dopamine D-1 regulation of caudate neurotensin mRNA in the presence or absence of the nigrostriatal dopamine pathway .
2532557	0	Dopamine	0,8	neurotensin	59,70	Dopamine	neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY exert|nsubj|receptors exert|nmod|systems systems|compound|END_ENTITY	Dopamine D2 receptors exert tonic regulation over discrete neurotensin systems of the rat brain .
11784783	0	Dopamine	0,8	norepinephrine_transporter	28,54	Dopamine	norepinephrine transporter	MESH:D004298	20538(Tax:10090)	Chemical	Gene	uptake|amod|START_ENTITY uptake|nmod|END_ENTITY	Dopamine uptake through the norepinephrine_transporter in brain regions with low levels of the dopamine_transporter : evidence from knock-out mouse lines .
12590617	0	Dopamine	40,48	part_1	32,38	Dopamine	part 1	MESH:D004298	25859	Chemical	Gene	hitchhiker|nsubj|START_ENTITY hitchhiker|advmod|END_ENTITY	Neurotransmission of cognition , part_1 , Dopamine is a hitchhiker in frontal cortex : norepinephrine transporters regulate dopamine .
10516317	0	Dopamine	0,8	parvalbumin	17,28	Dopamine	parvalbumin	MESH:D004298	25269(Tax:10116)	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|expression expression|compound|END_ENTITY	Dopamine affects parvalbumin expression during cortical development in vitro .
8961281	0	Dopamine	0,8	progesterone_receptor	33,54	Dopamine	progesterone receptor	MESH:D004298	18667(Tax:10090)	Chemical	Gene	requires|nsubj|START_ENTITY requires|dobj|END_ENTITY	Dopamine requires the unoccupied progesterone_receptor to induce sexual_behavior in mice .
117385	0	Dopamine	0,8	prolactin	46,55	Dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|potentials potentials|nmod|line line|compound|END_ENTITY	Dopamine inhibition of action potentials in a prolactin secreting cell line is modulated by oestrogen .
12535623	0	Dopamine	0,8	prolactin	129,138	Dopamine	prolactin	MESH:D004298	100303694(Tax:9103)	Chemical	Gene	infusion|amod|START_ENTITY intestinal|nsubj|infusion intestinal|dobj|END_ENTITY	Dopamine infusion into the third ventricle increases gene expression of hypothalamic vasoactive intestinal peptide and pituitary prolactin and luteinizing_hormone_beta_subunit in the turkey .
15708766	0	Dopamine	0,8	prolactin	62,71	Dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	treatment|amod|START_ENTITY reduces|nsubj|treatment reduces|dobj|concentration concentration|compound|END_ENTITY	Dopamine agonist treatment before and after the birth reduces prolactin concentration but does not impair paternal responsiveness in Djungarian hamsters , Phodopus campbelli .
1662167	0	Dopamine	0,8	prolactin	40,49	Dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Dopamine inhibits cell swelling-induced prolactin secretion in MMQ cells by blocking Ca2 + influx .
20553721	0	Dopamine	3,11	prolactin	87,96	Dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	subtype|compound|START_ENTITY mediates|nsubj|subtype mediates|nmod|release release|compound|END_ENTITY	D2 Dopamine receptor subtype mediates the inhibitory effect of dopamine on TRH-induced prolactin release from the bullfrog pituitary .
2813444	0	Dopamine	0,8	prolactin	104,113	Dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	speeds|amod|START_ENTITY speeds|dep|evidence evidence|nmod|involvement involvement|compound|END_ENTITY	Dopamine antagonist speeds up tail regeneration in lizards exposed to continuous darkness : evidence for prolactin involvement .
487998	0	Dopamine	0,8	prolactin	72,81	Dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	levels|amod|START_ENTITY levels|nmod|secretion secretion|compound|END_ENTITY	Dopamine levels in hypophysial stalk plasma of the rat during surges of prolactin secretion induced by cervical stimulation .
55861	0	Dopamine	8,16	prolactin	35,44	Dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Letter : Dopamine and inhibition of prolactin and growth-hormone secretion .
58180	0	Dopamine	0,8	prolactin	27,36	Dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Dopamine and inhibition of prolactin and growth-hormone secretion .
6133307	0	Dopamine	0,8	prolactin	106,115	Dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	serotonin|amod|START_ENTITY receptor|compound|serotonin receptor|acl|blocking blocking|nmod|level level|compound|END_ENTITY	Dopamine , serotonin and alpha-adrenergic receptor blocking activities in serum and their relationships to prolactin level in schizophrenic patients receiving long-term chlorpromazine treatment .
6151431	0	Dopamine	0,8	prolactin	20,29	Dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	control|amod|START_ENTITY control|nmod|secretion secretion|compound|END_ENTITY	Dopamine control of prolactin secretion in multiple_endocrine_neoplasia_type_I .
7007906	0	Dopamine	0,8	prolactin	21,30	Dopamine	prolactin	MESH:D004298	707052(Tax:9544)	Chemical	Gene	START_ENTITY|dep|effects effects|nmod|END_ENTITY	Dopamine : effects on prolactin and luteinizing hormone secretion in ovariectomized rhesus_macaques after transection of the pituitary stalk .
8371076	0	Dopamine	0,8	prolactin	58,67	Dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	analogues|compound|START_ENTITY act|nsubj|analogues act|xcomp|centrally centrally|xcomp|stimulate stimulate|dobj|secretion secretion|compound|END_ENTITY	Dopamine D1 receptor analogues act centrally to stimulate prolactin secretion in ewes .
9173350	2	Dopamine	124,132	prolactin	155,164	Dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	control|amod|START_ENTITY control|nmod|secretion secretion|compound|END_ENTITY	Dopamine inhibitory control of prolactin secretion -RSB- .
2963967	0	Dopamine	0,8	proopiomelanocortin	23,42	Dopamine	proopiomelanocortin	MESH:D004298	24664(Tax:10116)	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|expression expression|compound|END_ENTITY	Dopamine inhibition of proopiomelanocortin gene expression in the intermediate lobe of the pituitary .
2566577	2	Dopamine	230,238	renin	274,279	Dopamine	renin	MESH:D004298	24715(Tax:10116)	Chemical	Gene	stimulated|nsubj|START_ENTITY stimulated|dobj|release release|compound|END_ENTITY	Dopamine -LRB- 10 -LRB- -5 -RRB- M -RRB- significantly stimulated renin release compared with control .
21525301	0	Dopamine	0,8	serotonin_transporter	26,47	Dopamine	serotonin transporter	MESH:D004298	25553(Tax:10116)	Chemical	Gene	transport|amod|START_ENTITY transport|nmod|END_ENTITY	Dopamine transport by the serotonin_transporter : a mechanistically distinct mode of substrate translocation .
2118609	0	Dopamine	0,8	thyrotropin-releasing_hormone	71,100	Dopamine	thyrotropin-releasing hormone	MESH:D004298	7200	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|acl|stimulated stimulated|nmod|END_ENTITY	Dopamine inhibits the arachidonate and prolactin release stimulated by thyrotropin-releasing_hormone through an islet-activating_protein-sensitive GTP-binding protein in anterior pituitary cells .
2503364	0	Dopamine	0,8	thyrotropin-releasing_hormone	36,65	Dopamine	thyrotropin-releasing hormone	MESH:D004298	25569(Tax:10116)	Chemical	Gene	withdrawal|amod|START_ENTITY withdrawal|nmod|translocation translocation|amod|END_ENTITY	Dopamine withdrawal and addition of thyrotropin-releasing_hormone stimulate membrane translocation of protein_kinase-C and phosphorylation of an endogenous 80K substrate in enriched lactotrophs .
3108135	0	Dopamine	0,8	thyrotropin-releasing_hormone	18,47	Dopamine	thyrotropin-releasing hormone	MESH:D004298	25569(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|amod|END_ENTITY	Dopamine inhibits thyrotropin-releasing_hormone release from rat adrenal gland in vitro .
3141796	0	Dopamine	0,8	thyrotropin-releasing_hormone	26,55	Dopamine	thyrotropin-releasing hormone	MESH:D004298	25569(Tax:10116)	Chemical	Gene	has|nsubj|START_ENTITY has|dobj|effect effect|nmod|mobilization mobilization|amod|END_ENTITY	Dopamine has no effect on thyrotropin-releasing_hormone mobilization of calcium from intracellular stores in rat anterior pituitary cells .
1680579	0	Dopamine	0,8	tyrosine_hydroxylase	37,57	Dopamine	tyrosine hydroxylase	MESH:D004298	25085(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|decarboxylase decarboxylase|amod|END_ENTITY	Dopamine increases the expression of tyrosine_hydroxylase and aromatic_amino_acid decarboxylase in primary cultures of fetal neurons .
22509170	0	Dopamine	0,8	tyrosine_hydroxylase	74,94	Dopamine	tyrosine hydroxylase	MESH:D004298	7054	Chemical	Gene	pathology|amod|START_ENTITY pathology|dep|analysis analysis|nmod|END_ENTITY	Dopamine pathology in schizophrenia : analysis of total and phosphorylated tyrosine_hydroxylase in the substantia nigra .
2565375	0	Dopamine	0,8	tyrosine_hydroxylase	55,75	Dopamine	tyrosine hydroxylase	MESH:D004298	25085(Tax:10116)	Chemical	Gene	autoreceptors|amod|START_ENTITY modulate|nsubj|autoreceptors modulate|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Dopamine autoreceptors modulate the phosphorylation of tyrosine_hydroxylase in rat striatal slices .
26225746	0	Dopamine	0,8	tyrosine_hydroxylase	94,114	Dopamine	tyrosine hydroxylase	MESH:D004298	25085(Tax:10116)	Chemical	Gene	potentiates|amod|START_ENTITY phosphorylation|nsubj|potentiates phosphorylation|nmod|Ser Ser|nmod|END_ENTITY	Dopamine or biopterin deficiency potentiates phosphorylation at -LRB- 40 -RRB- Ser and ubiquitination of tyrosine_hydroxylase to be degraded by the ubiquitin proteasome system .
9823482	0	Dopamine	0,8	tyrosine_hydroxylase	117,137	Dopamine	tyrosine hydroxylase	MESH:D004298	7054	Chemical	Gene	innervation|amod|START_ENTITY innervation|dep|analysis analysis|nmod|structures structures|compound|END_ENTITY	Dopamine innervation of a subclass of local circuit neurons in monkey prefrontal cortex : ultrastructural analysis of tyrosine_hydroxylase and parvalbumin immunoreactive structures .
22230479	0	Dovitinib	0,9	STAT3	143,148	Dovitinib	STAT3	MESH:C500007	6774	Chemical	Gene	sensitizes|nsubj|START_ENTITY sensitizes|nmod|inhibition inhibition|nmod|END_ENTITY	Dovitinib sensitizes hepatocellular_carcinoma cells to TRAIL and tigatuzumab , a novel anti-DR5 antibody , through SHP-1-dependent inhibition of STAT3 .
22230479	0	Dovitinib	0,9	TRAIL	55,60	Dovitinib	TRAIL	MESH:C500007	8743	Chemical	Gene	sensitizes|nsubj|START_ENTITY sensitizes|nmod|END_ENTITY	Dovitinib sensitizes hepatocellular_carcinoma cells to TRAIL and tigatuzumab , a novel anti-DR5 antibody , through SHP-1-dependent inhibition of STAT3 .
22581827	0	Dox	15,18	FOXM1	0,5	Dox	FOXM1	null	2305	Chemical	Gene	resistance|compound|START_ENTITY mediates|dobj|resistance mediates|nsubj|END_ENTITY	FOXM1 mediates Dox resistance in breast_cancer by enhancing DNA repair .
10726718	0	Doxazosin	0,9	Bcl-2	19,24	Doxazosin	Bcl-2	MESH:D017292	24224(Tax:10116)	Chemical	Gene	modifies|nsubj|START_ENTITY modifies|dobj|expression expression|amod|END_ENTITY	Doxazosin modifies Bcl-2 and Bax protein expression in the left ventricle of spontaneously hypertensive rats .
16631627	0	Doxazosin	0,9	GADD153	32,39	Doxazosin	GADD153	MESH:D017292	1649	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|nmod|END_ENTITY	Doxazosin induces activation of GADD153 and cleavage of focal_adhesion_kinase in cardiomyocytes en route to apoptosis .
16631627	0	Doxazosin	0,9	focal_adhesion_kinase	56,77	Doxazosin	focal adhesion kinase	MESH:D017292	5747	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|nmod|END_ENTITY	Doxazosin induces activation of GADD153 and cleavage of focal_adhesion_kinase in cardiomyocytes en route to apoptosis .
1826187	0	Doxazosin	0,9	insulin	21,28	Doxazosin	insulin	MESH:D017292	3630	Chemical	Gene	effects|compound|START_ENTITY effects|nmod|END_ENTITY	Doxazosin effects on insulin and glucose in hypertensive patients .
8269449	0	Doxazosin	0,9	insulin	19,26	Doxazosin	insulin	MESH:D017292	3630	Chemical	Gene	improves|nsubj|START_ENTITY improves|dobj|sensitivity sensitivity|compound|END_ENTITY	Doxazosin improves insulin sensitivity in hypertensive patients .
15112179	0	Doxercalciferol	0,15	PTH	34,37	Doxercalciferol	PTH	MESH:C042533	5741	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|levels levels|compound|END_ENTITY	Doxercalciferol safely suppresses PTH levels in patients with secondary_hyperparathyroidism associated with chronic_kidney_disease stages 3 and 4 .
20689763	0	Doxorubicin	31,42	Artemin	0,7	Doxorubicin	Artemin	MESH:D004317	9048	Chemical	Gene	Sensitivity|nmod|START_ENTITY Sensitivity|compound|END_ENTITY	Artemin Reduces Sensitivity to Doxorubicin and Paclitaxel in Endometrial_Carcinoma Cells through Specific Regulation of CD24 .
20626886	0	Doxorubicin	0,11	B7-H1	39,44	Doxorubicin	B7-H1	MESH:D004317	29126	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|compound|END_ENTITY	Doxorubicin downregulates cell surface B7-H1 expression and upregulates its nuclear expression in breast_cancer cells : role of B7-H1 as an anti-apoptotic molecule .
26504757	0	Doxorubicin	0,11	Bax	20,23	Doxorubicin	Bax	MESH:D004317	581	Chemical	Gene	Ratio|compound|START_ENTITY Ratio|compound|END_ENTITY	Doxorubicin Changes Bax / Bcl-xL Ratio , Caspase-8_and_9 in Breast_Cancer Cells .
26504757	0	Doxorubicin	0,11	Bcl-xL	25,31	Doxorubicin	Bcl-xL	MESH:D004317	598	Chemical	Gene	Ratio|compound|START_ENTITY Ratio|compound|END_ENTITY	Doxorubicin Changes Bax / Bcl-xL Ratio , Caspase-8_and_9 in Breast_Cancer Cells .
20689763	0	Doxorubicin	31,42	CD24	120,124	Doxorubicin	CD24	MESH:D004317	100133941	Chemical	Gene	Sensitivity|nmod|START_ENTITY Sensitivity|nmod|END_ENTITY	Artemin Reduces Sensitivity to Doxorubicin and Paclitaxel in Endometrial_Carcinoma Cells through Specific Regulation of CD24 .
16878501	0	Doxorubicin	62,73	CD38	15,19	Doxorubicin	CD38	MESH:D004317	952	Chemical	Gene	induced|nmod|START_ENTITY expression|acl|induced expression|compound|END_ENTITY	-LSB- Alteration of CD38 expression and NAD + metabolism induced by Doxorubicin in bone marrow cells -RSB- .
26839832	0	Doxorubicin	70,81	Catalase	113,121	Doxorubicin	Catalase	MESH:D004317	24248(Tax:10116)	Chemical	Gene	Co-Chemotherapy|compound|START_ENTITY Fruit|nmod|Co-Chemotherapy Fraction|nmod|Fruit Fraction|dep|Evaluation Evaluation|nmod|END_ENTITY	Polysaccharide-Rich Fraction of Noni Fruit -LRB- Morinda citrifolia L. -RRB- as Doxorubicin Co-Chemotherapy : Evaluation of Catalase , Macrophages , and TCD8 + Lymphocytes .
15340041	0	Doxorubicin	0,11	DNMT1	21,26	Doxorubicin	DNMT1	MESH:D004317	1786	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Doxorubicin inhibits DNMT1 , resulting in conditional apoptosis .
18347152	0	Doxorubicin	0,11	FOXO3a	22,28	Doxorubicin	FOXO3a	MESH:D004317	2309	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Doxorubicin activates FOXO3a to induce the expression of multidrug resistance gene ABCB1 -LRB- MDR1 -RRB- in K562 leukemic cells .
26759238	0	Doxorubicin	64,75	HER2	5,9	Doxorubicin	HER2	MESH:D004317	2064	Chemical	Gene	Targeting|nmod|START_ENTITY Targeting|compound|END_ENTITY	Dual HER2 Targeting with Trastuzumab and Liposomal-Encapsulated Doxorubicin -LRB- MM-302 -RRB- Demonstrates Synergistic Antitumor Activity in Breast and Gastric_Cancer .
8095141	0	Doxorubicin	0,11	MDR-1	48,53	Doxorubicin	MDR-1	MESH:D004317	5243	Chemical	Gene	resistance|compound|START_ENTITY resistance|dep|END_ENTITY	Doxorubicin resistance in human melanoma cells : MDR-1 and glutathione_S-transferase pi gene expression .
26101222	0	Doxorubicin	131,142	Mammalian_Target_of_Rapamycin	56,85	Doxorubicin	Mammalian Target of Rapamycin	MESH:D004317	2475	Chemical	Gene	Sensitizes|xcomp|START_ENTITY Sensitizes|nsubj|END_ENTITY	Targeted Inhibition of Phosphoinositide_3-Kinase -LRB- PI3K -RRB- / Mammalian_Target_of_Rapamycin -LRB- mTOR -RRB- Sensitizes Pancreatic_Cancer Cells to Doxorubicin without Exacerbating Cardiac_Toxicity .
26927339	0	Doxorubicin	26,37	Myostatin	0,9	Doxorubicin	Myostatin	MESH:D004317	29152(Tax:10116)	Chemical	Gene	Damage|compound|START_ENTITY END_ENTITY|nmod|Damage	Myostatin as a Marker for Doxorubicin Induced Cardiac Damage .
26295136	0	Doxorubicin	18,29	P-Glycoprotein	92,106	Doxorubicin	P-Glycoprotein	MESH:D004317	5243	Chemical	Gene	Multidrug|compound|START_ENTITY Micelles|nmod|Multidrug Resistance|nsubj|Micelles Resistance|advcl|Inhibiting Inhibiting|dobj|Expression Expression|nmod|END_ENTITY	Mixed Micelles of Doxorubicin Overcome Multidrug Resistance by Inhibiting the Expression of P-Glycoprotein .
1684906	0	Doxorubicin	0,11	P-glycoprotein	171,185	Doxorubicin	P-glycoprotein	MESH:D004317	5243	Chemical	Gene	selected|nsubj|START_ENTITY selected|ccomp|characterised characterised|nmod|verapamil verapamil|nmod|absence absence|nmod|overexpression overexpression|amod|END_ENTITY	Doxorubicin selected multidrug-resistant small_cell_lung_cancer cell lines characterised by elevated cytoplasmic Ca2 + and resistance modulation by verapamil in absence of P-glycoprotein overexpression .
19383919	0	Doxorubicin	0,11	P-glycoprotein	104,118	Doxorubicin	P-glycoprotein	MESH:D004317	5243	Chemical	Gene	nanoparticles|amod|START_ENTITY overcome|nsubj|nanoparticles overcome|ccomp|multidrug multidrug|advcl|inhibiting inhibiting|dobj|END_ENTITY	Doxorubicin and paclitaxel-loaded lipid-based nanoparticles overcome multidrug resistance by inhibiting P-glycoprotein and depleting ATP .
9585065	0	Doxorubicin	0,11	P-glycoprotein	34,48	Doxorubicin	P-glycoprotein	MESH:D004317	5243	Chemical	Gene	induced|nsubj|START_ENTITY induced|dobj|expression expression|nmod|END_ENTITY	Doxorubicin induced expression of P-glycoprotein in a canine osteosarcoma cell line .
26503561	0	Doxorubicin	20,31	STAT3	59,64	Doxorubicin	STAT3	MESH:D004317	6774	Chemical	Gene	Sensitivity|compound|START_ENTITY Sensitivity|nmod|END_ENTITY	Berberine Increases Doxorubicin Sensitivity by Suppressing STAT3 in Lung_Cancer .
26536361	0	Doxorubicin	94,105	STAT3	83,88	Doxorubicin	STAT3	MESH:D004317	20848(Tax:10090)	Chemical	Gene	Toxicity|compound|START_ENTITY END_ENTITY|nmod|Toxicity	FL3 , a Synthetic Flavagline and Ligand of Prohibitins , Protects Cardiomyocytes via STAT3 from Doxorubicin Toxicity .
20442777	0	Doxorubicin	0,11	TGFbeta	40,47	Doxorubicin	TGFbeta	MESH:D004317	21803(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|combination combination|nmod|inhibitor inhibitor|compound|END_ENTITY	Doxorubicin in combination with a small TGFbeta inhibitor : a potential novel therapy for metastatic breast_cancer in mouse models .
15289869	0	Doxorubicin	0,11	TRAIL	24,29	Doxorubicin	TRAIL	MESH:D004317	8743	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|cytotoxicity cytotoxicity|amod|END_ENTITY	Doxorubicin potentiates TRAIL cytotoxicity and apoptosis and can overcome TRAIL-resistance in rhabdomyosarcoma cells .
27062773	0	Doxorubicin	11,22	abcb4	26,31	Doxorubicin	abcb4	MESH:D004317	100136865(Tax:7955)	Chemical	Gene	START_ENTITY|nmod|Expression Expression|compound|END_ENTITY	-LSB- Effect of Doxorubicin on abcb4 Gene Expression in Zebrafish -LRB- Danio_rerio -RRB- Embryos -RSB- .
10601122	0	Doxorubicin	0,11	atrial_natriuretic_peptide	46,72	Doxorubicin	atrial natriuretic peptide	MESH:D004317	24602(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|brain brain|nmod|expression expression|amod|END_ENTITY	Doxorubicin selectively inhibits brain versus atrial_natriuretic_peptide gene expression in cultured neonatal rat myocytes .
15880572	0	Doxorubicin	0,11	c-jun_N-terminal_kinase	126,149	Doxorubicin	c-jun N-terminal kinase	MESH:D004317	5599	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|pathway pathway|amod|END_ENTITY	Doxorubicin induces expression of multidrug_resistance-associated_protein_1 in human small cell lung_cancer cell lines by the c-jun_N-terminal_kinase pathway .
16766856	0	Doxorubicin	0,11	caspase-3	47,56	Doxorubicin	caspase-3	MESH:D004317	25402(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Doxorubicin induces apoptosis by activation of caspase-3 in cultured cardiomyocytes in vitro and rat cardiac ventricles in vivo .
26743901	0	Doxorubicin	68,79	eIF2a	36,41	Doxorubicin	eIF2a	MESH:D004317	1965	Chemical	Gene	Sensitivity|compound|START_ENTITY Sensitivity|amod|END_ENTITY	Salubrinal-Mediated Upregulation of eIF2a Phosphorylation Increases Doxorubicin Sensitivity in MCF-7 / ADR Cells .
20709190	0	Doxorubicin	0,11	endothelin-1	69,81	Doxorubicin	endothelin-1	MESH:D004317	1906	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|nmod|END_ENTITY	Doxorubicin selectively suppresses mRNA expression and production of endothelin-1 in endothelial cells .
16635388	0	Doxorubicin	51,62	heat_shock_protein_72	26,47	Doxorubicin	heat shock protein 72	MESH:D004317	24472(Tax:10116)	Chemical	Gene	-LSB-|nmod|START_ENTITY -LSB-|dobj|effect effect|nmod|END_ENTITY	-LSB- The protective effect of heat_shock_protein_72 by Doxorubicin in cold ischemia-reperfusion_injury of the rat liver -RSB- .
26101222	0	Doxorubicin	131,142	mTOR	87,91	Doxorubicin	mTOR	MESH:D004317	21977(Tax:10090)	Chemical	Gene	Sensitizes|xcomp|START_ENTITY Sensitizes|nsubj|Mammalian_Target_of_Rapamycin Mammalian_Target_of_Rapamycin|appos|END_ENTITY	Targeted Inhibition of Phosphoinositide_3-Kinase -LRB- PI3K -RRB- / Mammalian_Target_of_Rapamycin -LRB- mTOR -RRB- Sensitizes Pancreatic_Cancer Cells to Doxorubicin without Exacerbating Cardiac_Toxicity .
21556506	0	Doxorubicin	126,137	p-glycoprotein	13,27	Doxorubicin	p-glycoprotein	MESH:D004317	18704(Tax:10090)	Chemical	Gene	cell-lines|nmod|START_ENTITY cell-lines|nsubj|Induction Induction|acl|END_ENTITY	Induction of p-glycoprotein , glutathione-s-transferase-pi , catalase , C-fos and C-erbb1 in rodent cell-lines after exposure to Doxorubicin , ethanol and caffeine .
21566973	0	Doxorubicin	0,11	p-glycoprotein	45,59	Doxorubicin	p-glycoprotein	MESH:D004317	287115(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|nmod|activity activity|amod|END_ENTITY	Doxorubicin enhances transient expression of p-glycoprotein and modulates activity and isoform expression of protein-kinase-C in ah66 rat hepatoma-cells .
21573380	0	Doxorubicin	14,25	p-glycoprotein	51,65	Doxorubicin	p-glycoprotein	MESH:D004317	5243	Chemical	Gene	sensitivity|compound|START_ENTITY sensitivity|nmod|expression expression|amod|END_ENTITY	Modulation of Doxorubicin sensitivity and level of p-glycoprotein expression in human colon-carcinoma cells by ectopic and orthotopic environments in nude-mice .
12049655	0	Doxorubicin	0,11	p53	64,67	Doxorubicin	p53	MESH:D004317	7157	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|product product|nmod|END_ENTITY	Doxorubicin and octreotide induce a 40 kDa breakdown product of p53 in human hepatoma and tumoral colon cell lines .
12698197	0	Doxorubicin	0,11	p53	50,53	Doxorubicin	p53	MESH:D004317	7157	Chemical	Gene	act|nsubj|START_ENTITY act|nmod|expression expression|compound|END_ENTITY	Doxorubicin and vinorelbine act independently via p53 expression and p38 activation respectively in breast_cancer cell lines .
18269916	0	Doxorubicin	55,66	p53	27,30	Doxorubicin	p53	MESH:D004317	7157	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|Induction Induction|nmod|p21 p21|nmod|p65 p65|nmod|cells cells|nummod|END_ENTITY	Induction of p21 by p65 in p53 null cells treated with Doxorubicin .
24801380	0	Doxorubicin	0,11	p53	84,87	Doxorubicin	p53	MESH:D004317	7157	Chemical	Gene	START_ENTITY|acl|induced induced|dobj|activity activity|nmod|END_ENTITY	Doxorubicin and 5-fluorouracil induced accumulation and transcriptional activity of p53 are independent of the phosphorylation at serine 15 in MCF-7 breast_cancer cells .
25501132	0	Doxorubicin	111,122	p53	66,69	Doxorubicin	p53	MESH:D004317	7157	Chemical	Gene	Delivers|nmod|START_ENTITY Delivers|nmod|Reactivation Reactivation|compound|END_ENTITY	CD99 Triggering in Ewing_Sarcoma Delivers a Lethal Signal through p53 Pathway Reactivation and Cooperates with Doxorubicin .
11855807	0	Doxorubicin	0,11	ryanodine_receptor	49,67	Doxorubicin	ryanodine receptor	MESH:D004317	100009439(Tax:9986)	Chemical	Gene	effects|compound|START_ENTITY effects|nmod|expression expression|compound|END_ENTITY	Doxorubicin and C-13_deoxydoxorubicin effects on ryanodine_receptor gene expression .
22382681	0	Doxorubicin	0,11	transglutaminase_2	63,81	Doxorubicin	transglutaminase 2	MESH:D004317	7052	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|nmod|END_ENTITY	Doxorubicin induces the persistent activation of intracellular transglutaminase_2 that protects from cell death .
22844460	0	Doxycycline	0,11	AKT	35,38	Doxycycline	AKT	MESH:D004318	11651(Tax:10090)	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Doxycycline regulated induction of AKT in murine prostate drives proliferation independently of p27 cyclin dependent kinase inhibitor downregulation .
26087309	0	Doxycycline	0,11	DNA-PK	27,33	Doxycycline	DNA-PK	MESH:D004318	5591	Chemical	Gene	down-regulates|amod|START_ENTITY END_ENTITY|nsubj|down-regulates	Doxycycline down-regulates DNA-PK and radiosensitizes tumor initiating cells : Implications for more effective radiation therapy .
7978787	0	Doxycycline	0,11	MMP-2	72,77	Doxycycline	MMP-2	MESH:D004318	4313	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|xcomp|gelatinase gelatinase|dobj|expression expression|appos|END_ENTITY	Doxycycline and chemically modified tetracyclines inhibit gelatinase A -LRB- MMP-2 -RRB- gene expression in human skin keratinocytes .
22232712	0	Doxycycline	14,25	MMP-9	62,67	Doxycycline	MMP-9	MESH:D004318	4318	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|Expression Expression|nmod|END_ENTITY	The Effect of Doxycycline on PMA-Induced MUC5B Expression via MMP-9 and p38 in NCI-H292 Cells .
22232712	0	Doxycycline	14,25	MUC5B	41,46	Doxycycline	MUC5B	MESH:D004318	727897	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|Expression Expression|compound|END_ENTITY	The Effect of Doxycycline on PMA-Induced MUC5B Expression via MMP-9 and p38 in NCI-H292 Cells .
11850258	0	Doxycycline	0,11	P_glycoprotein	34,48	Doxycycline	P glycoprotein	MESH:D004318	5243	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Doxycycline induces expression of P_glycoprotein in MCF-7 breast_carcinoma cells .
15256372	0	Doxycycline	0,11	SERCA2a	36,43	Doxycycline	SERCA2a	MESH:D004318	11938(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Doxycycline inducible expression of SERCA2a improves calcium handling and reverts cardiac_dysfunction in pressure overload-induced cardiac_hypertrophy .
18606869	0	Doxycycline	0,11	VE-cadherin	43,54	Doxycycline	VE-cadherin	MESH:D004318	1003	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Doxycycline induces membrane expression of VE-cadherin on endothelial cells and prevents vascular_hyperpermeability .
15647741	0	Doxycycline	0,11	caspase-3	28,37	Doxycycline	caspase-3	MESH:D004318	836	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|activation activation|amod|END_ENTITY	Doxycycline reduces cleaved caspase-3 and microglial activation in an animal model of neonatal_hypoxia-ischemia .
10937565	0	Doxycycline	0,11	interleukin-1	26,39	Doxycycline	interleukin-1	MESH:D004318	3552	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Doxycycline inhibition of interleukin-1 in the corneal epithelium .
21876619	0	Doxycycline	0,11	matrix_metalloproteinase-2	47,73	Doxycycline	matrix metalloproteinase-2	MESH:D004318	81686(Tax:10116)	Chemical	Gene	blocks|amod|START_ENTITY gastric_ulcer|nsubj|blocks gastric_ulcer|advcl|regulating regulating|dobj|activity activity|amod|END_ENTITY	Doxycycline blocks gastric_ulcer by regulating matrix_metalloproteinase-2 activity and oxidative stress .
23928836	0	Doxycycline	0,11	matrix_metalloproteinase-2	28,54	Doxycycline	matrix metalloproteinase-2	MESH:D004318	4313	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|activity activity|amod|END_ENTITY	Doxycycline reduces cardiac matrix_metalloproteinase-2 activity but does not ameliorate myocardial_dysfunction during reperfusion in coronary artery bypass patients undergoing cardiopulmonary bypass .
16809218	0	Doxycycline	0,11	monocyte_chemoattractant_protein-1	22,56	Doxycycline	monocyte chemoattractant protein-1	MESH:D004318	6347	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|xcomp|END_ENTITY	Doxycycline decreases monocyte_chemoattractant_protein-1 in human lung epithelial cells .
10556567	0	Draculin	0,8	factor_X	116,124	Draculin	factor X	MESH:C094183	2159	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Draculin , the anticoagulant factor in vampire bat saliva , is a tight-binding , noncompetitive inhibitor of activated factor_X .
25371698	0	Droperidol	90,100	Connexin43	76,86	Droperidol	Connexin43	MESH:D004329	24392(Tax:10116)	Chemical	Gene	Rats|compound|START_ENTITY END_ENTITY|nmod|Rats	P6 Electroacupuncture Improved QTc Interval Prolongation by Upregulation of Connexin43 in Droperidol Treated Rats .
14581969	0	Drotrecogin	0,11	protein_C	46,55	Drotrecogin	protein C	null	5624	Chemical	Gene	alfa|compound|START_ENTITY alfa|appos|END_ENTITY	Drotrecogin alfa -LRB- recombinant human activated protein_C -RRB- in severe sepsis -- a New Zealand viewpoint .
26947884	0	Droxinostat	0,11	Histone_Deacetylase	15,34	Droxinostat	Histone Deacetylase	MESH:C554680	9734	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|compound|END_ENTITY	Droxinostat , a Histone_Deacetylase Inhibitor , Induces Apoptosis in Hepatocellular_Carcinoma Cell Lines via Activation of the Mitochondrial Pathway and Downregulation of FLIP .
8639859	0	Du	69,71	RhD	55,58	Du	RhD	null	6007	Chemical	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Molecular basis of the altered antigenic expression of RhD in weak D -LRB- Du -RRB- and RhC/e in RN phenotypes .
21438784	0	Du-14	27,32	TNF-a	67,72	Du-14	TNF-a	MESH:C103321	7124	Chemical	Gene	Effects|dep|START_ENTITY Effects|nmod|END_ENTITY	Effects of some acupoints -LRB- Du-14 , Li-11 , St-36 , and Sp-6 -RRB- on serum TNF-a and hsCRP levels in healthy young subjects .
27039732	0	DuP-697	93,100	COX-2	101,106	DuP-697	COX-2	MESH:C064874	4513	Chemical	Gene	Inhibitor|compound|START_ENTITY Inhibitor|compound|END_ENTITY	Effects of a Multikinase Inhibitor Motesanib -LRB- AMG_706 -RRB- Alone and Combined with the Selective DuP-697 COX-2 Inhibitor on Colorectal_Cancer_Cells .
9024174	0	DuP_532	0,7	angiotensin_II	12,26	DuP 532	angiotensin II	MESH:C069045	183	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	DuP_532 , an angiotensin_II receptor antagonist : first administration and comparison with losartan .
1527721	0	DuP_753	85,92	Angiotensin_II	0,14	DuP 753	Angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	losartan|appos|START_ENTITY effect|nmod|losartan END_ENTITY|dep|effect	Angiotensin_II and monocrotaline-induced pulmonary_hypertension : effect of losartan -LRB- DuP_753 -RRB- , a nonpeptide angiotensin type 1 receptor antagonist .
7884581	0	DuP_753	27,34	Angiotensin_II	0,14	DuP 753	Angiotensin II	MESH:D019808	183	Chemical	Gene	antagonists|dobj|START_ENTITY antagonists|nsubj|END_ENTITY	Angiotensin_II antagonists DuP_753 and TCV_116 .
8240673	0	DuP_753	106,113	Angiotensin_II	0,14	DuP 753	Angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	studies|nmod|START_ENTITY isoforms|dep|studies isoforms|compound|END_ENTITY	Angiotensin_II receptor isoforms in the rat adrenal gland : studies with the selective subtype antagonists DuP_753 and CGP42112A .
1425998	0	DuP_753	25,32	angiotensin_II	42,56	DuP 753	angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	Enhancement|appos|START_ENTITY Enhancement|acl|induced induced|dobj|antagonism antagonism|amod|END_ENTITY	Enhancement of losartan -LRB- DuP_753 -RRB- - induced angiotensin_II receptor antagonism by PD123177 in rats .
1474085	0	DuP_753	22,29	angiotensin_II	58,72	DuP 753	angiotensin II	MESH:D019808	183	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|responses responses|nmod|END_ENTITY	Inhibitory effects of DuP_753 and EXP3174 on responses to angiotensin_II in pulmonary vascular bed of the cat .
1618259	0	DuP_753	124,131	angiotensin_II	46,60	DuP 753	angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	blocked|nmod|START_ENTITY blocked|nsubjpass|Drinking Drinking|acl|induced induced|nmod|injection injection|nmod|END_ENTITY	Drinking induced by subcutaneous injection of angiotensin_II in the rat is blocked by the selective AT1 receptor antagonist DuP_753 but not by the selective AT2 receptor antagonist WL_19 .
1810594	0	DuP_753	36,43	angiotensin_II	57,71	DuP 753	angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|receptors receptors|compound|END_ENTITY	Access of peripherally administered DuP_753 to rat brain angiotensin_II receptors .
1854456	0	DuP_753	0,7	angiotensin_II	45,59	DuP 753	angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	antagonist|nsubj|START_ENTITY antagonist|nmod|receptors receptors|amod|END_ENTITY	DuP_753 is a potent nonpeptide antagonist of angiotensin_II receptors in isolated perfused rat kidney and cultured renal cells .
1854457	0	DuP_753	82,89	angiotensin_II	55,69	DuP 753	angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Characterization of the renal microvascular effects of angiotensin_II antagonist , DuP_753 : studies in isolated perfused hydronephrotic kidneys .
1994182	0	DuP_753	89,96	angiotensin_II	62,76	DuP 753	angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	Differential regional haemodynamic effects of the non-peptide angiotensin_II antagonist , DuP_753 , in water-replete and water-deprived Brattleboro rats .
2013151	0	DuP_753	23,30	angiotensin_II	43,57	DuP 753	angiotensin II	MESH:D019808	183	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Oral administration of DuP_753 , a specific angiotensin_II receptor antagonist , to normal male volunteers .
2017158	0	DuP_753	0,7	angiotensin_II	38,52	DuP 753	angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	antagonize|nsubj|START_ENTITY antagonize|dobj|effects effects|nmod|END_ENTITY	DuP_753 can antagonize the effects of angiotensin_II in rat liver .
2069778	0	DuP_753	20,27	angiotensin_II	42,56	DuP 753	angiotensin II	MESH:D019808	183	Chemical	Gene	effects|nmod|START_ENTITY vascular|nmod|effects vascular|nsubj|antagonist antagonist|amod|END_ENTITY	In vitro effects of DuP_753 , a nonpeptide angiotensin_II receptor antagonist , on human platelets and rat vascular smooth muscle cells .
2185150	0	DuP_753	22,29	angiotensin_II	34,48	DuP 753	angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Hypotensive action of DuP_753 , an angiotensin_II antagonist , in spontaneously hypertensive rats .
2232490	0	DuP_753	38,45	angiotensin_II	60,74	DuP 753	angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	START_ENTITY|appos|receptor receptor|compound|END_ENTITY	Proximal nephron and renal effects of DuP_753 , a nonpeptide angiotensin_II receptor antagonist .
2243344	0	DuP_753	83,90	angiotensin_II	33,47	DuP 753	angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	studies|dep|START_ENTITY studies|nmod|ligands ligands|compound|END_ENTITY	Functional studies of nonpeptide angiotensin_II receptor subtype-specific ligands : DuP_753 -LRB- AII-1 -RRB- and PD123177 -LRB- AII-2 -RRB- .
8385523	0	DuP_753	35,42	angiotensin_II	48,62	DuP 753	angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	losartan|appos|START_ENTITY losartan|appos|antagonist antagonist|amod|END_ENTITY	Renin release induced by losartan -LRB- DuP_753 -RRB- , an angiotensin_II receptor antagonist .
8450454	0	DuP_753	38,45	angiotensin_II	75,89	DuP 753	angiotensin II	MESH:D019808	183	Chemical	Gene	effects|nmod|START_ENTITY Analysis|nmod|effects Analysis|nmod|responses responses|nmod|END_ENTITY	Analysis of the inhibitory effects of DuP_753 and EXP_3174 on responses to angiotensin_II in the feline hindquarters vascular bed .
17999062	0	Dup-697	0,7	COX-2	20,25	Dup-697	COX-2	MESH:C064874	4513	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Dup-697 , a specific COX-2 inhibitor , suppresses growth and induces apoptosis on K562 leukemia cells by cell-cycle arrest and caspase-8 activation .
15510237	0	Dutasteride	0,11	5-alpha-reductase	40,57	Dutasteride	5-alpha-reductase	MESH:C108373	6715	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	Dutasteride : a potent dual inhibitor of 5-alpha-reductase for benign_prostatic_hyperplasia .
14627182	0	Dutasteride	0,11	5-alpha_reductase	19,36	Dutasteride	5-alpha reductase	MESH:C108373	6715	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Dutasteride : a new 5-alpha_reductase inhibitor for men with lower urinary tract symptoms secondary to benign_prostatic_hyperplasia .
15945422	0	Dutasteride	1,12	5-alpha_reductase	32,49	Dutasteride	5-alpha reductase	MESH:C108373	6715	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	-LSB- Dutasteride -LRB- Avodart -RRB- : a novel 5-alpha_reductase inhibitor for treatment of benign_prostate_hypertrophy -RSB- .
16569804	0	Dutasteride	0,11	5-alpha_reductase	20,37	Dutasteride	5-alpha reductase	MESH:C108373	6715	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Dutasteride : a dual 5-alpha_reductase inhibitor for the treatment of symptomatic benign_prostatic_hyperplasia .
23815285	0	Dutasteride	88,99	5-alpha_reductase	58,75	Dutasteride	5-alpha reductase	MESH:C108373	6715	Chemical	Gene	events|dep|START_ENTITY events|nmod|inhibitor inhibitor|amod|END_ENTITY	Systematic review evaluating cardiovascular events of the 5-alpha_reductase inhibitor - Dutasteride .
14716738	0	Dutasteride	0,11	5alpha-reductase	22,38	Dutasteride	5alpha-reductase	MESH:C108373	6715	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Dutasteride , the dual 5alpha-reductase inhibitor , inhibits androgen action and promotes cell death in the LNCaP_prostate_cancer cell line .
15757426	0	Dutasteride	0,11	5alpha-reductase	39,55	Dutasteride	5alpha-reductase	MESH:C108373	6715	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	Dutasteride : a novel dual inhibitor of 5alpha-reductase for benign_prostatic_hyperplasia .
20380656	0	Dutogliptin	0,11	DPP4	25,29	Dutogliptin	DPP4	MESH:C552164	1803	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Dutogliptin , a selective DPP4 inhibitor , improves glycaemic control in patients with type 2 diabetes : a 12-week , double-blind , randomized , placebo-controlled , multicentre trial .
20336594	0	Dutogliptin	0,11	dipeptidyl_peptidase-4	15,37	Dutogliptin	dipeptidyl peptidase-4	MESH:C552164	1803	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Dutogliptin , a dipeptidyl_peptidase-4 inhibitor for the treatment of type_2_diabetes_mellitus .
17587400	0	Dydrogesterone	0,14	lipoprotein_lipase	57,75	Dydrogesterone	lipoprotein lipase	MESH:D004394	4023	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Dydrogesterone and norethisterone regulate expression of lipoprotein_lipase and hormone-sensitive_lipase in human subcutaneous abdominal adipocytes .
19710132	0	Dynamin	0,7	decay-accelerating_factor	43,68	Dynamin	decay-accelerating factor	null	1604	Chemical	Gene	entry|amod|START_ENTITY entry|nmod|END_ENTITY	Dynamin - and lipid raft-dependent entry of decay-accelerating_factor -LRB- DAF -RRB- - binding and non-DAF-binding coxsackieviruses into nonpolarized cells .
2565237	0	Dynorphin	0,9	ANP	36,39	Dynorphin	ANP	MESH:D004399	24602(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|nmod|END_ENTITY	Dynorphin stimulates the release of ANP from isolated rat atria .
18942066	0	Dynorphin	0,9	NEP	19,22	Dynorphin	NEP	MESH:D004399	17380(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	Dynorphin inhibits NEP activity in R1 .1 mouse thymoma cells .
7702795	0	E-3174	40,46	angiotensin_II	51,65	E-3174	angiotensin II	MESH:C066026	183	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Pharmacodynamic activity of intravenous E-3174 , an angiotensin_II antagonist , in patients with essential hypertension .
21212416	0	E-3810	0,6	VEGFR	37,42	E-3810	VEGFR	MESH:C569877|MESH:C063129	3791	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	E-3810 is a potent dual inhibitor of VEGFR and FGFR that exerts antitumor activity in multiple preclinical models .
11264663	0	E-5842	72,78	Fibroblast_growth_factor-2	0,26	E-5842	Fibroblast growth factor-2	MESH:C117757	54250(Tax:10116)	Chemical	Gene	modulated|nmod|START_ENTITY modulated|nsubjpass|END_ENTITY	Fibroblast_growth_factor-2 is selectively modulated in the rat brain by E-5842 , a preferential sigma-1_receptor ligand and putative atypical antipsychotic .
9881578	0	E-5842	14,20	Fos	87,90	E-5842	Fos	MESH:C117757	314322(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|compound|END_ENTITY	The effect of E-5842 , a sigma receptor ligand and potential atypical antipsychotic , on Fos expression in rat forebrain .
15069660	0	E-6087	39,45	COX-2	53,58	E-6087	COX-2	MESH:C427706	4513	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Enantioselective HPLC determination of E-6087 , a new COX-2 inhibitor , in human plasma : Validation and pharmacokinetic application .
8764357	0	E2011	0,5	monoamine_oxidase_type_A	53,77	E2011	monoamine oxidase type A	MESH:C091708	29253(Tax:10116)	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	E2011 a novel , selective and reversible inhibitor of monoamine_oxidase_type_A .
10368299	0	E2020	49,54	acetylcholinesterase	13,33	E2020	acetylcholinesterase	MESH:C076946	11423(Tax:10090)	Chemical	Gene	complexed|nmod|START_ENTITY END_ENTITY|acl|complexed	Structure of acetylcholinesterase complexed with E2020 -LRB- Aricept -RRB- : implications for the design of new anti-Alzheimer drugs .
8535413	0	E2020	134,139	acetylcholinesterase	35,55	E2020	acetylcholinesterase	MESH:C076946	43	Chemical	Gene	methylpiperidine_hydrochloride|appos|START_ENTITY yl|dep|methylpiperidine_hydrochloride study|dep|yl study|nmod|inhibition inhibition|nmod|END_ENTITY	Kinetic study on the inhibition of acetylcholinesterase by 1-benzyl-4 - -LSB- -LRB- 5,6-dimethoxy-1-indanon -RRB- -2 - yl -RSB- methylpiperidine_hydrochloride -LRB- E2020 -RRB- .
8734490	0	E2020	70,75	acetylcholinesterase	39,59	E2020	acetylcholinesterase	MESH:C076946	83817(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|inhibitor inhibitor|compound|END_ENTITY	The effect of the selective reversible acetylcholinesterase inhibitor E2020 on extracellular acetylcholine and biogenic amine levels in rat cortex .
7794791	0	E2F	38,41	c-myc	45,50	E2F	c-myc	null	4609	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	A direct role of transcription factor E2F in c-myc gene expression during granulocytic and macrophage-like differentiation of HL60 cells .
7760804	9	E2F-1	917,922	E2F-5	853,858	E2F-1	E2F-1	null	1869	Chemical	Gene	related|nmod|START_ENTITY related|nsubj|END_ENTITY	E2F-5 is more closely related to E2F-4 -LRB- 78 % similarity -RRB- than to E2F-1 -LRB- 57 % similarity -RRB- .
7760804	9	E2F-4	886,891	E2F-5	853,858	E2F-4	E2F-1	null	1869	Chemical	Gene	related|nmod|START_ENTITY related|nsubj|END_ENTITY	E2F-5 is more closely related to E2F-4 -LRB- 78 % similarity -RRB- than to E2F-1 -LRB- 57 % similarity -RRB- .
15580623	0	E2F4	69,73	fibroblast_growth_factor_receptor_1	14,49	E2F4	fibroblast growth factor receptor 1	null	39564(Tax:7227)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Repression of fibroblast_growth_factor_receptor_1 gene expression by E2F4 in skeletal muscle cells .
16973152	0	E3024	0,5	dipeptidyl_peptidase-IV	139,162	E3024	dipeptidyl peptidase-IV	MESH:C515375	25253(Tax:10116)	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|amod|END_ENTITY	E3024 , 3-but-2-ynyl-5-methyl-2-piperazin-1-yl-3 ,5 - dihydro-4H-imidazo -LSB- 4,5-d -RSB- pyridazin-4-one_tosylate , is a novel , selective and competitive dipeptidyl_peptidase-IV inhibitor .
7802694	0	E3810	32,37	proton_pump	9,20	E3810	proton pump	MESH:C569877|MESH:C063129	24216(Tax:10116)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Specific proton_pump inhibitors E3810 and lansoprazole affect the recovery process of gastric secretion in rats differently .
8913512	0	E4177	79,84	angiotensin_II_type_1_receptor	36,66	E4177	angiotensin II type 1 receptor	MESH:C083778	81638(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Localization of a novel non-peptide angiotensin_II_type_1_receptor antagonist , E4177 , in rat adrenal glomerulosa .
15833764	0	E5564	33,38	Toll-like_receptor_4	0,20	E5564	Toll-like receptor 4	MESH:C404742	21898(Tax:10090)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Toll-like_receptor_4 antagonist -LRB- E5564 -RRB- prevents the chronic airway response to inhaled lipopolysaccharide .
19661804	0	E5564	39,44	toll-like_receptor_4	49,69	E5564	toll-like receptor 4	MESH:C404742	7099	Chemical	Gene	trial|appos|START_ENTITY trial|appos|antagonist antagonist|amod|END_ENTITY	Phase 2 trial of eritoran_tetrasodium -LRB- E5564 -RRB- , a toll-like_receptor_4 antagonist , in patients with severe sepsis .
22872782	0	E5564	183,188	toll-like_receptor_4	51,71	E5564	toll-like receptor 4	MESH:C404742	7099	Chemical	Gene	lipopolysaccharide|appos|START_ENTITY inhibited|nmod|lipopolysaccharide inhibited|nsubjpass|fusion fusion|amod|END_ENTITY	Respiratory_syncytial_virus fusion protein-induced toll-like_receptor_4 -LRB- TLR4 -RRB- signaling is inhibited by the TLR4 antagonists Rhodobacter_sphaeroides lipopolysaccharide and eritoran -LRB- E5564 -RRB- and requires direct interaction with MD-2 .
19255727	0	E6020	76,81	TLR4	62,66	E6020	TLR4	null	21898(Tax:10090)	Chemical	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	MF59 emulsion is an effective delivery system for a synthetic TLR4 agonist -LRB- E6020 -RRB- .
22832252	0	E6020	73,78	TLR4	59,63	E6020	TLR4	null	7099	Chemical	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	MF59 oil-in-water emulsion in combination with a synthetic TLR4 agonist -LRB- E6020 -RRB- is a potent adjuvant for a combination Meningococcus vaccine .
17931157	0	E6020	0,5	Toll-like_receptor_4	19,39	E6020	Toll-like receptor 4	null	7099	Chemical	Gene	START_ENTITY|dep|agonist agonist|compound|END_ENTITY	E6020 : a synthetic Toll-like_receptor_4 agonist as a vaccine adjuvant .
1479538	0	E6080	106,111	uridine_diphosphate-glucuronyltransferase	46,87	E6080	uridine diphosphate-glucuronyltransferase	MESH:C064507	24861(Tax:10116)	Chemical	Gene	activities|nmod|START_ENTITY activities|amod|END_ENTITY	Species difference and tissue distribution of uridine_diphosphate-glucuronyltransferase activities toward E6080 , 1-naphthol and 4-hydroxybiphenyl .
26822154	0	E6201	28,33	FLT3	129,133	E6201	FLT3	MESH:C545120	2322	Chemical	Gene	Activity|compound|START_ENTITY Activity|nmod|END_ENTITY	The Dual MEK/FLT3 Inhibitor E6201 Exerts Cytotoxic Activity against Acute Myeloid_Leukemia Cells Harboring Resistance-Conferring FLT3 Mutations .
17449905	10	EB1089	1381,1387	DKK-1	1396,1401	EB1089	DKK-1	MESH:C078903	13380(Tax:10090)	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Remarkably , in vivo treatment with the vitamin_D analogue EB1089 induced DKK-1 protein expression in SW480-ADH cells xenografted in immunodeficient mice , and a correlation was observed in the expression of VDR and DKK-1 RNA in a series of 32 human colorectal_tumours .
16115727	0	EB1089	0,6	vitamin_D_receptor	10,28	EB1089	vitamin D receptor	MESH:C078903	22337(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	EB1089 , a vitamin_D_receptor agonist , reduces proliferation and decreases_tumor growth rate in a mouse model of hormone-induced mammary cancer .
9099905	0	EB1089	36,42	vitamin_D_receptor	82,100	EB1089	vitamin D receptor	MESH:C078903	7421	Chemical	Gene	interact|amod|START_ENTITY analogues|dobj|interact analogues|nmod|END_ENTITY	The noncalcemic vitamin_D analogues EB1089 and 22-oxacalcitriol interact with the vitamin_D_receptor and suppress parathyroid_hormone-related_peptide gene expression .
10777214	0	EBNA-3	43,49	XAP-2	56,61	EBNA-3	XAP-2	null	9049	Chemical	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Epstein-Barr_virus encoded nuclear protein EBNA-3 binds XAP-2 , a protein associated with Hepatitis_B virus X antigen .
24429368	0	EBNA3C	37,43	H2AX	55,59	EBNA3C	H2AX	null	3014	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|compound|END_ENTITY	Epstein-Barr_virus essential antigen EBNA3C attenuates H2AX expression .
21131419	0	EC144	0,5	heat_shock_protein_90	32,53	EC144	heat shock protein 90	MESH:C555354	104408(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	EC144 , a synthetic inhibitor of heat_shock_protein_90 , blocks innate and adaptive immune responses in models of inflammation and autoimmunity .
71853	0	EDTA	40,44	neuraminidase	61,74	EDTA	neuraminidase	MESH:D004492	4758	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nsubj|effect	Enhancement and stabilization effect of EDTA on Sendai_virus neuraminidase activity .
8299406	0	EDTA	23,27	parathyroid_hormone	47,66	EDTA	parathyroid hormone	MESH:D004492	5741	Chemical	Gene	treatment|compound|START_ENTITY Effects|nmod|treatment Effects|nmod|END_ENTITY	Effects of intravenous EDTA treatment on serum parathyroid_hormone -LRB- 1-84 -RRB- and biochemical markers of bone turnover .
10049331	0	EDTA	14,18	parvalbumin	26,37	EDTA	parvalbumin	MESH:D004492	25269(Tax:10116)	Chemical	Gene	mimics|nsubj|START_ENTITY mimics|dobj|END_ENTITY	Intracellular EDTA mimics parvalbumin in the promotion of skeletal muscle relaxation .
402166	0	EDTA	15,19	renin	32,37	EDTA	renin	MESH:D004492	24715(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|secretion secretion|compound|END_ENTITY	The effects of EDTA and EGTA on renin secretion .
6769499	0	EDTA	55,59	transferrin	40,51	EDTA	transferrin	MESH:D004492	7018	Chemical	Gene	release|nmod|START_ENTITY release|nmod|END_ENTITY	The kinetics of iron release from human transferrin by EDTA .
2905267	0	EEDQ	24,28	dopamine_D-1_receptor	36,57	EEDQ	dopamine D-1 receptor	MESH:C000470	1812	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Differential effects of EEDQ on the dopamine_D-1_receptor in vivo and in vitro .
9746574	0	EF5668	153,159	PspA	143,147	EF5668	PspA	null	20387(Tax:10090)	Chemical	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|END_ENTITY	Comparison of the PspA sequence from Streptococcus_pneumoniae EF5668 to the previously identified PspA sequence from strain Rx1 and ability of PspA from EF5668 to elicit protection against pneumococci of different capsular types .
9746574	0	EF5668	62,68	PspA	143,147	EF5668	PspA	null	20387(Tax:10090)	Chemical	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|END_ENTITY	Comparison of the PspA sequence from Streptococcus_pneumoniae EF5668 to the previously identified PspA sequence from strain Rx1 and ability of PspA from EF5668 to elicit protection against pneumococci of different capsular types .
19325462	0	EF6265	0,6	thrombin-activatable_fibrinolysis_inhibitor	39,82	EF6265	thrombin-activatable fibrinolysis inhibitor	MESH:C487111	113936(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	EF6265 , a novel inhibitor of activated thrombin-activatable_fibrinolysis_inhibitor , protects against sepsis-induced organ_dysfunction in rats .
16513643	0	EG3287	71,77	NP-1	53,57	EG3287	NP-1	MESH:C511613	8829	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|appos|END_ENTITY	Characterization of a bicyclic peptide neuropilin-1 -LRB- NP-1 -RRB- antagonist -LRB- EG3287 -RRB- reveals importance of vascular_endothelial_growth_factor exon 8 for NP-1 binding and role of NP-1 in KDR signaling .
16513643	0	EG3287	71,77	neuropilin-1	39,51	EG3287	neuropilin-1	MESH:C511613	8829	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Characterization of a bicyclic peptide neuropilin-1 -LRB- NP-1 -RRB- antagonist -LRB- EG3287 -RRB- reveals importance of vascular_endothelial_growth_factor exon 8 for NP-1 binding and role of NP-1 in KDR signaling .
16797120	0	EGCG	20,24	AMPK	57,61	EGCG	AMPK	CHEBI:4806	5563	Chemical	Gene	START_ENTITY|nmod|cells cells|nmod|END_ENTITY	Apoptotic effect of EGCG in HT-29 colon_cancer cells via AMPK signal pathway .
22521609	0	EGCG	0,4	AhR	91,94	EGCG	AhR	CHEBI:4806	196	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|inhibition inhibition|nmod|END_ENTITY	EGCG protects endothelial cells against PCB_126-induced inflammation through inhibition of AhR and induction of Nrf2-regulated genes .
23141425	0	EGCG	0,4	CTGF	14,18	EGCG	CTGF	CHEBI:4806	64032(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	EGCG inhibits CTGF expression via blocking NF-kB activation in cardiac fibroblast .
15327833	0	EGCG	10,14	Ets-1	69,74	EGCG	Ets-1	CHEBI:4806	2113	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	Effect of EGCG , a major component of green tea , on the expression of Ets-1 , c-Fos , and c-Jun during angiogenesis in vitro .
26293782	0	EGCG	0,4	G-CSF	13,18	EGCG	G-CSF	CHEBI:4806	1440	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	EGCG induces G-CSF expression and neutrophilia in experimental sepsis .
16416603	0	EGCG	0,4	HER3	28,32	EGCG	HER3	CHEBI:4806	2065	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	EGCG inhibits activation of HER3 and expression of cyclooxygenase-2 in human colon_cancer cells .
24965403	0	EGCG	0,4	HIF-1a	33,39	EGCG	HIF-1a	CHEBI:4806	3091	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|nmod|END_ENTITY	EGCG decreases the expression of HIF-1a and VEGF and cell growth in MCF-7 breast_cancer cells .
21787753	0	EGCG	0,4	IL-1RI	19,25	EGCG	IL-1RI	CHEBI:4806	3554	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|compound|END_ENTITY	EGCG downregulates IL-1RI expression and suppresses IL-1-induced tumorigenic factors in human pancreatic_adenocarcinoma cells .
22082235	0	EGCG	0,4	MMP-2	90,95	EGCG	MMP-2	CHEBI:4806	4313	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|expression expression|compound|END_ENTITY	EGCG inhibits the invasion of highly invasive CL1-5 lung_cancer cells through suppressing MMP-2 expression via JNK signaling and induces G2/M arrest .
16114557	0	EGCG	11,15	MnSOD	32,37	EGCG	MnSOD	CHEBI:4806	6648	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	-LSB- Effect of EGCG on H2O2-induced MnSOD gene expression in cultured spiral_ganglion cells -RSB- .
22348037	0	EGCG	0,4	STAT3	82,87	EGCG	STAT3	CHEBI:4806	6774	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|advcl|inhibiting inhibiting|dobj|END_ENTITY	EGCG enhances the therapeutic potential of gemcitabine and CP690550 by inhibiting STAT3 signaling pathway in human pancreatic_cancer .
11259102	0	EGCG	0,4	VEGF	75,79	EGCG	VEGF	CHEBI:4806	7422	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|inhibiting inhibiting|dobj|induction induction|amod|END_ENTITY	EGCG , a major component of green tea , inhibits tumour growth by inhibiting VEGF induction in human colon_carcinoma cells .
12811578	0	EGCG	51,55	VEGF	84,88	EGCG	VEGF	CHEBI:4806	7422	Chemical	Gene	tea|appos|START_ENTITY polyphenols|nmod|tea polyphenols|nmod|END_ENTITY	Comparative effects of polyphenols from green tea -LRB- EGCG -RRB- and soybean -LRB- genistein -RRB- on VEGF and IL-8 release from normal human keratinocytes stimulated with the proinflammatory cytokine TNFalpha .
14996703	0	EGCG	118,122	VEGF	0,4	EGCG	VEGF	CHEBI:4806	7422	Chemical	Gene	epigallocatechin-3-gallate|appos|START_ENTITY component|appos|epigallocatechin-3-gallate modulated|nmod|component modulated|nsubjpass|status status|compound|END_ENTITY	VEGF receptor phosphorylation status and apoptosis is modulated by a green tea component , epigallocatechin-3-gallate -LRB- EGCG -RRB- , in B-cell_chronic_lymphocytic_leukemia .
15817996	0	EGCG	0,4	VEGF	47,51	EGCG	VEGF	CHEBI:4806	397157(Tax:9823)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	EGCG , a major component of green tea , inhibits VEGF production by swine granulosa cells .
15327833	0	EGCG	10,14	c-Fos	76,81	EGCG	c-Fos	CHEBI:4806	2353	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of EGCG , a major component of green tea , on the expression of Ets-1 , c-Fos , and c-Jun during angiogenesis in vitro .
16416603	0	EGCG	0,4	cyclooxygenase-2	51,67	EGCG	cyclooxygenase-2	CHEBI:4806	5743	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	EGCG inhibits activation of HER3 and expression of cyclooxygenase-2 in human colon_cancer cells .
15794642	10	EGCG	1632,1636	hsp90	1657,1662	EGCG	hsp90	CHEBI:4806	3320	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|nmod|END_ENTITY	These data implicate a model in which EGCG inhibits release of hsp90 from the AhR , stabilizing the complex in an intermediary state associated with XAP2 .
16053920	0	EGCG	0,4	insulin-like_growth_factor-1_receptor	32,69	EGCG	insulin-like growth factor-1 receptor	CHEBI:4806	3480	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	EGCG inhibits activation of the insulin-like_growth_factor-1_receptor in human colon_cancer cells .
18719023	0	EGCG	0,4	p27kip1	16,23	EGCG	p27kip1	CHEBI:4806	1027	Chemical	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	EGCG stabilizes p27kip1 in E2-stimulated MCF-7 cells through down-regulation of the Skp2 protein .
15107597	0	EGIS-7625	11,20	5-HT2B_receptor	50,65	EGIS-7625	5-HT2B receptor	MESH:C489704	3357	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Effects of EGIS-7625 , a selective and competitive 5-HT2B_receptor antagonist .
21215314	0	EGT1442	0,7	SGLT2	32,37	EGT1442	SGLT2	null	246787(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	EGT1442 , a potent and selective SGLT2 inhibitor , attenuates blood_glucose and HbA -LRB- 1c -RRB- levels in db/db mice and prolongs the survival of stroke-prone rats .
15901353	0	EGb_761	32,39	cytochrome_P450	53,68	EGb 761	cytochrome P450	MESH:C063170	25251(Tax:10116)	Chemical	Gene	extract|dobj|START_ENTITY extract|nmod|END_ENTITY	Influence of the Ginkgo extract EGb_761 on rat liver cytochrome_P450 and steroid metabolism and excretion in rats and man .
22189672	0	EGb_761	40,47	cytochrome_P450	59,74	EGb 761	cytochrome P450	MESH:C063170	4051	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effect of Ginkgo_biloba special extract EGb_761 on human cytochrome_P450 activity : a cocktail interaction study in healthy volunteers .
8940403	0	EGb_761	116,123	peripheral-type_benzodiazepine_receptor	22,61	EGb 761	peripheral-type benzodiazepine receptor	MESH:C063170	24230(Tax:10116)	Chemical	Gene	synthesis|nmod|START_ENTITY synthesis|nsubj|regulation regulation|nmod|END_ENTITY	In vivo regulation of peripheral-type_benzodiazepine_receptor and glucocorticoid synthesis by Ginkgo_biloba extract EGb_761 and isolated ginkgolides .
19135347	0	EGb_761	88,95	vascular_endothelial_growth_factor	15,49	EGb 761	vascular endothelial growth factor	MESH:C063170	7422	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Inhibitions of vascular_endothelial_growth_factor expression and foam cell formation by EGb_761 , a special extract of Ginkgo_biloba , in oxidatively modified low-density lipoprotein-induced human THP-1 monocytes cells .
25725286	0	EHT_1864	0,8	Ras-related_C3_botulinum_toxin_substrate_1	40,82	EHT 1864	Ras-related C3 botulinum toxin substrate 1	MESH:C506907	5879	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	EHT_1864 , a small molecule inhibitor of Ras-related_C3_botulinum_toxin_substrate_1 -LRB- Rac1 -RRB- , attenuates glucose-stimulated insulin secretion in pancreatic b-cells .
25725286	0	EHT_1864	0,8	insulin	121,128	EHT 1864	insulin	MESH:C506907	3630	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|secretion secretion|compound|END_ENTITY	EHT_1864 , a small molecule inhibitor of Ras-related_C3_botulinum_toxin_substrate_1 -LRB- Rac1 -RRB- , attenuates glucose-stimulated insulin secretion in pancreatic b-cells .
1886174	0	EK-399	57,63	enkephalin	38,48	EK-399	enkephalin	MESH:C057683	29237(Tax:10116)	Chemical	Gene	self-administration|amod|START_ENTITY self-administration|nmod|END_ENTITY	Intravenous self-administration of an enkephalin analog , EK-399 , by rats .
16324698	0	EK-6136	0,7	Cdc25B	73,79	EK-6136	Cdc25B	MESH:C508437	994	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	EK-6136 -LRB- 3-methyl-4 - -LRB- O-methyl-oximino -RRB- -1 - phenylpyrazolin-5-one -RRB- : a novel Cdc25B inhibitor with antiproliferative activity .
14749472	0	EKB-569	215,222	epidermal_growth_factor_receptor	171,203	EKB-569	epidermal growth factor receptor	MESH:C413879	1956	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Phosphorylation of extracellular_signal-regulated_kinase_1_and_2 , protein kinase B , and signal_transducer_and_activator_of_transcription_3 are differently inhibited by an epidermal_growth_factor_receptor inhibitor , EKB-569 , in tumor cells and normal human keratinocytes .
16364494	0	EKB-569	0,7	epidermal_growth_factor_receptor	28,60	EKB-569	epidermal growth factor receptor	MESH:C413879	1956	Chemical	Gene	tyrosine|ccomp|START_ENTITY tyrosine|nsubj|END_ENTITY	EKB-569 , a new irreversible epidermal_growth_factor_receptor tyrosine kinase inhibitor , with clinical activity in patients with non-small_cell_lung_cancer with acquired resistance to gefitinib .
16710023	0	EKB-569	17,24	epidermal_growth_factor_receptor	59,91	EKB-569	epidermal growth factor receptor	MESH:C413879	1956	Chemical	Gene	study|nmod|START_ENTITY study|appos|inhibitor inhibitor|nmod|END_ENTITY	Phase I study of EKB-569 , an irreversible inhibitor of the epidermal_growth_factor_receptor , in patients with advanced solid tumors .
18172273	0	EKB-569	49,56	epidermal_growth_factor_receptor	91,123	EKB-569	epidermal growth factor receptor	MESH:C413879	1956	Chemical	Gene	study|nmod|START_ENTITY Phase|xcomp|study kinase|advcl|Phase kinase|nsubj|inhibitor inhibitor|nmod|tyrosine tyrosine|compound|END_ENTITY	Phase I pharmacokinetic/pharmacodynamic study of EKB-569 , an irreversible inhibitor of the epidermal_growth_factor_receptor tyrosine kinase , in combination with irinotecan , 5-fluorouracil , and leucovorin -LRB- FOLFIRI -RRB- in first-line treatment of patients with metastatic colorectal_cancer .
1944188	0	EM-523	28,34	motilin	11,18	EM-523	motilin	MESH:C061752	481748(Tax:9615)	Chemical	Gene	Effect|appos|START_ENTITY Effect|nmod|agonist agonist|compound|END_ENTITY	-LSB- Effect of motilin agonist , EM-523 on gastrointestinal_motility -RSB- .
8536863	0	EM523	37,42	motilin	21,28	EM523	motilin	MESH:C061752	481748(Tax:9615)	Chemical	Gene	agonist|dobj|START_ENTITY agonist|nsubj|Effect Effect|nmod|END_ENTITY	Effect of nonpeptide motilin agonist EM523 on release of gut and pancreatic hormones in conscious dogs .
9088872	0	EM574	0,5	motilin	40,47	EM574	motilin	MESH:C090116	100009276(Tax:9986)	Chemical	Gene	agonist|nsubj|START_ENTITY agonist|amod|END_ENTITY	EM574 , an erythromycin derivative , is a motilin receptor agonist in the rabbit .
26111701	0	EMA401	92,98	Angiotensin_II_type_2_receptor	43,73	EMA401	Angiotensin II type 2 receptor	null	186	Chemical	Gene	antagonist|dobj|START_ENTITY antagonist|nsubj|efficacy efficacy|nmod|END_ENTITY	Mechanisms underlying clinical efficacy of Angiotensin_II_type_2_receptor -LRB- AT2R -RRB- antagonist EMA401 in neuropathic_pain : clinical tissue and in vitro studies .
21865856	0	EMD638683	0,9	SGK	19,22	EMD638683	SGK	MESH:C569030	20393(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	EMD638683 , a novel SGK inhibitor with antihypertensive potency .
2439795	0	EMD_33512	12,21	beta_1-adrenoceptor	43,62	EMD 33512	beta 1-adrenoceptor	MESH:D017298	153	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Bisoprolol -LRB- EMD_33512 -RRB- , a highly selective beta_1-adrenoceptor antagonist : in vitro and in vivo studies .
9623723	0	EMD_57033	48,57	Ca2	73,76	EMD 57033	Ca2	MESH:C070609	477928(Tax:9615)	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Different chronotropic and inotropic effects of EMD_57033 and EMD_53998 , Ca2 + sensitizers , on isolated , blood-perfused dog heart preparations .
10831238	0	EMD_58265	62,71	renin	46,51	EMD 58265	renin	MESH:C094806	100358545(Tax:9986)	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|inhibitor inhibitor|compound|END_ENTITY	Greater blood pressure-lowering effect of the renin inhibitor EMD_58265 than an angiotensin-converting enzyme inhibitor in two-kidney one-clip Goldblatt rabbit .
9518537	0	ENA713	30,36	acetylcholinesterase	46,66	ENA713	acetylcholinesterase	MESH:C072506	83817(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Cerebro-protective effects of ENA713 , a novel acetylcholinesterase inhibitor , in closed_head_injury in the rat .
10485959	0	ENA_713	36,43	acetylcholinesterase	4,24	ENA 713	acetylcholinesterase	MESH:C072506	83817(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	The acetylcholinesterase inhibitor , ENA_713 -LRB- Exelon -RRB- , attenuates the working memory_impairment induced by scopolamine in an operant DNMTP task in rats .
24495669	0	ENMD-1068	0,9	protease-activated_receptor_2	13,42	ENMD-1068	protease-activated receptor 2	MESH:C518710	14063(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	ENMD-1068 , a protease-activated_receptor_2 antagonist , inhibits the development of endometriosis in a mouse model .
26636018	0	ENU	15,18	Otogelin	6,14	ENU	Otogelin	CHEBI:23995	18419(Tax:10090)	Chemical	Gene	model|compound|START_ENTITY model|compound|END_ENTITY	A new Otogelin ENU mouse model for autosomal-recessive nonsyndromic moderate hearing_impairment .
25892270	0	EPA	119,122	PPARy2	14,20	EPA	PPARy2	CHEBI:28364	5468	Chemical	Gene	induced|nmod|START_ENTITY Activation|acl|induced Activation|nmod|END_ENTITY	Activation of PPARy2 by PPARy1 through a functional PPRE in transdifferentiation of myoblasts to adipocytes induced by EPA .
17196878	0	EPA	11,14	p53	32,35	EPA	p53	CHEBI:28364	7157	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Conjugated EPA activates mutant p53 via lipid peroxidation and induces p53-dependent apoptosis in DLD-1 colorectal_adenocarcinoma human cells .
23199523	0	EPA	11,14	prostate-specific_antigen	58,83	EPA	prostate-specific antigen	CHEBI:28364	354	Chemical	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	Effects of EPA , y-linolenic_acid or coenzyme_Q10 on serum prostate-specific_antigen levels : a randomised , double-blind trial .
26965637	0	EPI-X4	56,62	CXCR4	92,97	EPI-X4	CXCR4	null	7852	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|nmod|END_ENTITY	Proteolytic processing of human serum albumin generates EPI-X4 , an endogenous antagonist of CXCR4 .
26645404	0	EPZ-5676	65,73	DOT1L	34,39	EPZ-5676	DOT1L	MESH:C583893	362831(Tax:10116)	Chemical	Gene	Metabolism|appos|START_ENTITY Metabolism|nmod|inhibitor inhibitor|compound|END_ENTITY	Metabolism and disposition of the DOT1L inhibitor , pinometostat -LRB- EPZ-5676 -RRB- , in rat , dog and human .
26005520	0	EPZ011989	0,9	EZH2	38,42	EPZ011989	EZH2	null	2146	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|compound|END_ENTITY	EPZ011989 , A Potent , Orally-Available EZH2 Inhibitor with Robust in Vivo Activity .
26228443	0	EPZ015666	37,46	PRMT5	108,113	EPZ015666	PRMT5	null	480242(Tax:9615)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|appos|END_ENTITY	Species differences in metabolism of EPZ015666 , an oxetane-containing protein_arginine_methyltransferase-5 -LRB- PRMT5 -RRB- inhibitor .
26294260	0	EPZ015666	37,46	PRMT5	108,113	EPZ015666	PRMT5	null	480242(Tax:9615)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|appos|END_ENTITY	Species differences in metabolism of EPZ015666 , an oxetane-containing protein_arginine_methyltransferase-5 -LRB- PRMT5 -RRB- inhibitor .
26228443	0	EPZ015666	37,46	protein_arginine_methyltransferase-5	70,106	EPZ015666	protein arginine methyltransferase-5	null	480242(Tax:9615)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Species differences in metabolism of EPZ015666 , an oxetane-containing protein_arginine_methyltransferase-5 -LRB- PRMT5 -RRB- inhibitor .
26294260	0	EPZ015666	37,46	protein_arginine_methyltransferase-5	70,106	EPZ015666	protein arginine methyltransferase-5	null	480242(Tax:9615)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Species differences in metabolism of EPZ015666 , an oxetane-containing protein_arginine_methyltransferase-5 -LRB- PRMT5 -RRB- inhibitor .
26985287	0	EPZ031686	44,53	SMYD3	100,105	EPZ031686	SMYD3	null	69726(Tax:10090)	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|compound|END_ENTITY	Novel Oxindole_Sulfonamides and Sulfamides : EPZ031686 , the First Orally Bioavailable Small Molecule SMYD3 Inhibitor .
23880196	0	EP_80317	0,8	CD36	12,16	EP 80317	CD36	MESH:C468852	12491(Tax:10090)	Chemical	Gene	START_ENTITY|appos|ligand ligand|compound|END_ENTITY	EP_80317 , a CD36 selective ligand , promotes reverse_cholesterol_transport in apolipoprotein_E-deficient mice .
19447495	0	ERB-041	0,7	ER_beta	21,28	ERB-041	ER beta	MESH:C478102	2100	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	ERB-041 , a selective ER_beta agonist , inhibits iNOS production in LPS-activated peritoneal macrophages of endometriosis via suppression of NF-kappaB activation .
20556817	0	ERB-041	64,71	estrogen_receptor_b	35,54	ERB-041	estrogen receptor b	MESH:C478102	2100	Chemical	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	Efficacy and safety of a selective estrogen_receptor_b agonist , ERB-041 , in patients with rheumatoid_arthritis : a 12-week , randomized , placebo-controlled , phase II study .
19447495	0	ERB-041	0,7	iNOS	47,51	ERB-041	iNOS	MESH:C478102	4843	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	ERB-041 , a selective ER_beta agonist , inhibits iNOS production in LPS-activated peritoneal macrophages of endometriosis via suppression of NF-kappaB activation .
1962804	0	ES-1005	34,41	renin	74,79	ES-1005	renin	MESH:C056080	5972	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|nmod|gene gene|compound|END_ENTITY	The effect of the renin inhibitor ES-1005 on the expression of the kidney renin gene in sodium-depleted marmosets .
2198366	0	ES-1005	28,35	renin	11,16	ES-1005	renin	MESH:C056080	5972	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	-LSB- Effect of renin inhibitor -LRB- ES-1005 -RRB- on expression of the kidney renin gene in sodium-depleted marmosets -RSB- .
2198366	0	ES-1005	28,35	renin	65,70	ES-1005	renin	MESH:C056080	5972	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|nmod|expression expression|nmod|gene gene|compound|END_ENTITY	-LSB- Effect of renin inhibitor -LRB- ES-1005 -RRB- on expression of the kidney renin gene in sodium-depleted marmosets -RSB- .
2485069	0	ES-1005	85,92	renin	29,34	ES-1005	renin	MESH:C056080	5972	Chemical	Gene	inhibitor|appos|START_ENTITY vitro|nsubj|inhibitor vitro|dobj|inhibition inhibition|nmod|END_ENTITY	In vitro inhibition of human renin by statine-containing tripeptide renin inhibitor -LRB- ES-1005 -RRB- .
2485069	0	ES-1005	85,92	renin	68,73	ES-1005	renin	MESH:C056080	5972	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	In vitro inhibition of human renin by statine-containing tripeptide renin inhibitor -LRB- ES-1005 -RRB- .
17951987	0	ES-1273	41,48	DNA_gyrase	27,37	ES-1273	DNA gyrase	null	7153	Chemical	Gene	Mechanism|nmod|START_ENTITY Mechanism|nmod|END_ENTITY	Mechanism of inhibition of DNA_gyrase by ES-1273 , a novel DNA_gyrase inhibitor .
17951987	0	ES-1273	41,48	DNA_gyrase	58,68	ES-1273	DNA gyrase	null	7153	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Mechanism of inhibition of DNA_gyrase by ES-1273 , a novel DNA_gyrase inhibitor .
1663967	0	ES-8891	27,34	renin	10,15	ES-8891	renin	MESH:C064483	5972	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Effect of renin inhibitor , ES-8891 , on renal renin secretion and storage in the marmoset : comparison with captopril .
1663967	0	ES-8891	27,34	renin	45,50	ES-8891	renin	MESH:C064483	5972	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|nmod|secretion secretion|compound|END_ENTITY	Effect of renin inhibitor , ES-8891 , on renal renin secretion and storage in the marmoset : comparison with captopril .
2112512	0	ES-8891	0,7	renin	45,50	ES-8891	renin	MESH:C064483	5972	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	ES-8891 , an orally active inhibitor of human renin .
6397732	0	ES52	11,15	enkephalinase	20,33	ES52	enkephalinase	MESH:C040246	24590(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effects of ES52 , an enkephalinase inhibitor , on responses of ventrobasal thalamic neurons in rat .
23459418	0	ESI-09	23,29	EPAC	61,65	ESI-09	EPAC	MESH:C579558	10411	Chemical	Gene	START_ENTITY|appos|Antagonist Antagonist|compound|END_ENTITY	Efficient Synthesis of ESI-09 , A Novel Non-cyclic Nucleotide EPAC Antagonist .
25791905	0	ESI-09	53,59	EPAC	66,70	ESI-09	EPAC	MESH:C579558	223864(Tax:10090)	Chemical	Gene	characterizations|nmod|START_ENTITY based|nsubj|characterizations based|dep|defining defining|nsubj|inhibitors inhibitors|compound|END_ENTITY	Biochemical and pharmacological characterizations of ESI-09 based EPAC inhibitors : defining the ESI-09 `` therapeutic window '' .
25791905	0	ESI-09	96,102	EPAC	66,70	ESI-09	EPAC	MESH:C579558	223864(Tax:10090)	Chemical	Gene	window|amod|START_ENTITY defining|dobj|window defining|nsubj|inhibitors inhibitors|compound|END_ENTITY	Biochemical and pharmacological characterizations of ESI-09 based EPAC inhibitors : defining the ESI-09 `` therapeutic window '' .
15816524	0	ET-18-OCH3	0,10	p70_S6_kinase	58,71	ET-18-OCH3	p70 S6 kinase	MESH:C026659	6198	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	ET-18-OCH3 inhibits the phosphorylation and activation of p70_S6_kinase in MCF-7 cells .
19742314	0	ET-743	30,36	ZNF93	0,5	ET-743	ZNF93	MESH:C099150	81931	Chemical	Gene	increases|nmod|START_ENTITY increases|nsubj|END_ENTITY	ZNF93 increases resistance to ET-743 -LRB- Trabectedin ; Yondelis -RRB- and PM00104 -LRB- Zalypsis -RRB- in human cancer cell lines .
21051136	0	ETP-45299	23,32	PI3K	87,91	ETP-45299	PI3K	MESH:C554740	5293	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|inhibition inhibition|compound|END_ENTITY	Pim_1 kinase inhibitor ETP-45299 suppresses cellular proliferation and synergizes with PI3K inhibition .
21492125	0	ETV6-LYN	30,38	STAT5	21,26	ETV6-LYN	STAT5	null	20850(Tax:10090)	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|nmod|protein	Direct activation of STAT5 by ETV6-LYN fusion protein promotes induction of myeloproliferative_neoplasm with myelofibrosis .
19129751	0	EVT_301	128,135	MAO-B	111,116	EVT 301	MAO-B	MESH:C540298	4129	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Assessment of MAO-B occupancy in the brain with PET and -LSB- 11C -RSB- - L-deprenyl-D2 : a dose-finding study with a novel MAO-B inhibitor , EVT_301 .
19129751	0	EVT_301	128,135	MAO-B	14,19	EVT 301	MAO-B	MESH:C540298	4129	Chemical	Gene	inhibitor|appos|START_ENTITY study|nmod|inhibitor L-deprenyl-D2|dep|study Assessment|dep|L-deprenyl-D2 Assessment|nmod|occupancy occupancy|amod|END_ENTITY	Assessment of MAO-B occupancy in the brain with PET and -LSB- 11C -RSB- - L-deprenyl-D2 : a dose-finding study with a novel MAO-B inhibitor , EVT_301 .
21852112	0	EW-7195	0,7	ALK5	30,34	EW-7195	ALK5	MESH:C568967	21812(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|kinase kinase|compound|END_ENTITY	EW-7195 , a novel inhibitor of ALK5 kinase inhibits EMT and breast_cancer metastasis to lung .
22968147	6	EX527	933,938	SIRT1	951,956	EX527	SIRT1	MESH:C550547	309757(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	In addition , resveratrol improved glucose-stimulated insulin secretion decreased by palmitate , which was abrogated by EX527 , a specific SIRT1 inhibitor .
23311358	0	EX527	124,129	SIRT1	36,41	EX527	SIRT1	MESH:C550547	23411	Chemical	Gene	analogue|compound|START_ENTITY nicotinamide_adenine_dinucleotide|appos|analogue bound|nmod|nicotinamide_adenine_dinucleotide domain|acl|bound domain|compound|END_ENTITY	The 2.5 crystal structure of the SIRT1 catalytic domain bound to nicotinamide_adenine_dinucleotide -LRB- NAD + -RRB- and an indole -LRB- EX527 analogue -RRB- reveals a novel mechanism of histone deacetylase inhibition .
19687349	0	EXP3179	85,92	PPARgamma	97,106	EXP3179	PPARgamma	MESH:C073600	5468	Chemical	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	Chronic treatment with losartan results in sufficient serum levels of the metabolite EXP3179 for PPARgamma activation .
7988654	0	EXP597	0,6	angiotensin_II	21,35	EXP597	angiotensin II	MESH:C090811	24179(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	EXP597 , a nonpeptide angiotensin_II receptor antagonist with high affinities for the angiotensin AT1 and AT2 receptor subtypes .
24292632	0	EZN-2968	15,23	HIF-1a	101,107	EZN-2968	HIF-1a	MESH:C533794	3091	Chemical	Gene	trial|nmod|START_ENTITY trial|appos|END_ENTITY	Pilot trial of EZN-2968 , an antisense oligonucleotide inhibitor of hypoxia-inducible_factor-1_alpha -LRB- HIF-1a -RRB- , in patients with refractory solid tumors .
24292632	0	EZN-2968	15,23	hypoxia-inducible_factor-1_alpha	67,99	EZN-2968	hypoxia-inducible factor-1 alpha	MESH:C533794	3091	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Pilot trial of EZN-2968 , an antisense oligonucleotide inhibitor of hypoxia-inducible_factor-1_alpha -LRB- HIF-1a -RRB- , in patients with refractory solid tumors .
24923332	0	EZN-3042	24,32	Survivin	0,8	EZN-3042	Survivin	MESH:C552302	442936(Tax:9615)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Survivin inhibition via EZN-3042 in canine lymphoma and osteosarcoma .
20391197	0	EZN-3042	81,89	survivin	19,27	EZN-3042	survivin	MESH:C552302	11799(Tax:10090)	Chemical	Gene	vivo|nmod|START_ENTITY growth|nmod|vivo Down-modulation|nmod|growth Down-modulation|nmod|expression expression|compound|END_ENTITY	Down-modulation of survivin expression and inhibition of tumor growth in vivo by EZN-3042 , a locked nucleic acid antisense oligonucleotide .
19321044	0	Ebastine	0,8	IFN-gamma	19,28	Ebastine	IFN-gamma	MESH:C058249	3458	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|production production|amod|END_ENTITY	Ebastine increases IFN-gamma production in patients with persistent_allergic_rhinitis .
26158899	0	Ebselen	0,7	QSOX1	17,22	Ebselen	QSOX1	MESH:C042986	5768	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	Ebselen inhibits QSOX1 enzymatic activity and suppresses invasion of pancreatic_and_renal_cancer cell lines .
18709644	0	Ebselen	0,7	Tumor_Necrosis_Factor	41,62	Ebselen	Tumor Necrosis Factor	MESH:C042986	7124	Chemical	Gene	sensitizes|nsubj|START_ENTITY sensitizes|nmod|END_ENTITY	Ebselen sensitizes glioblastoma cells to Tumor_Necrosis_Factor -LRB- TNFalpha -RRB- - induced apoptosis through two distinct pathways involving NF-kappaB downregulation and Fas-mediated formation of death inducing signaling complex .
14720501	0	Ebselen	0,7	c-Jun_N-terminal_kinase	53,76	Ebselen	c-Jun N-terminal kinase	MESH:C042986	5599	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|compound|END_ENTITY	Ebselen inhibits tumor_necrosis_factor-alpha-induced c-Jun_N-terminal_kinase activation and adhesion molecule expression in endothelial cells .
10933877	0	Ebselen	0,7	interleukin-6	22,35	Ebselen	interleukin-6	MESH:C042986	24498(Tax:10116)	Chemical	Gene	lowers|nsubj|START_ENTITY lowers|dobj|levels levels|amod|END_ENTITY	Ebselen lowers plasma interleukin-6 levels and glial heme_oxygenase-1 expression after focal photothrombotic brain_ischemia .
15125192	0	Ecdysone	1,9	cytochrome_P450	39,54	Ecdysone	cytochrome P450	MESH:D004440	4051	Chemical	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	-LSB- Ecdysone 20-monooxygenase activity of cytochrome_P450 in plants and cell culture of Ajuga reptans L -RSB- .
26696544	0	Ecdysteroid	0,11	c-Myc	90,95	Ecdysteroid	c-Myc	MESH:D026461	100862782	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|activation activation|nmod|END_ENTITY	Ecdysteroid promotes cell cycle progression in the Bombyx wing disc through activation of c-Myc .
6146468	0	Ecdysterone	0,11	acetylcholinesterase	20,40	Ecdysterone	acetylcholinesterase	MESH:D004441	83817(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Ecdysterone induces acetylcholinesterase in mammalian brain .
12668620	0	Echinoid	21,29	Neuroglian	0,10	Echinoid	Neuroglian	null	31792(Tax:7227)	Chemical	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Neuroglian activates Echinoid to antagonize the Drosophila EGF receptor signaling pathway .
16204079	0	Echinomycin	0,11	hypoxia-inducible_factor-1	43,69	Echinomycin	hypoxia-inducible factor-1	MESH:D004448	3091	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|activity activity|amod|END_ENTITY	Echinomycin , a small-molecule inhibitor of hypoxia-inducible_factor-1 DNA-binding activity .
21985601	0	Echinomycin	0,11	vascular_endothelial_growth_factor	35,69	Echinomycin	vascular endothelial growth factor	MESH:D004448	22339(Tax:10090)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|induction induction|nmod|regeneration regeneration|compound|END_ENTITY	Echinomycin decreases induction of vascular_endothelial_growth_factor and hepatocyte regeneration in acetaminophen toxicity in mice .
8142399	0	Ecotin	0,6	factor_Xa	75,84	Ecotin	factor Xa	null	2159	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Ecotin is a potent anticoagulant and reversible tight-binding inhibitor of factor_Xa .
20477754	0	Ecstasy	0,7	brain-derived_neurotrophic_factor	64,97	Ecstasy	brain-derived neurotrophic factor	null	627	Chemical	Gene	START_ENTITY|dep|levels levels|nmod|END_ENTITY	Ecstasy -LRB- MDMA -RRB- - addicted subjects show increased serum levels of brain-derived_neurotrophic_factor , independently from a rise of drug-induced psychotic_symptoms .
16184764	0	Ectoine	0,7	hsp70	65,70	Ectoine	hsp70	CHEBI:27592	3308	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Ectoine from halophilic microorganisms induces the expression of hsp70 and hsp70B ' in human keratinocytes modulating the proinflammatory response .
25282183	0	Edaravone	11,20	MMP-9	73,78	Edaravone	MMP-9	MESH:C005435	4318	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of Edaravone , a Free Radical Scavenger , on Circulating Levels of MMP-9 and Hemorrhagic_Transformation in Patients with Intravenous Thrombolysis Using Low-dose Alteplase .
25850013	0	Edaravone	0,9	brain-derived_neurotrophic_factor	19,52	Edaravone	brain-derived neurotrophic factor	MESH:C005435	12064(Tax:10090)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|amod|END_ENTITY	Edaravone enhances brain-derived_neurotrophic_factor production in the ischemic mouse brain .
18496239	0	Edaravone	0,9	iNOS	36,40	Edaravone	iNOS	MESH:C005435	18126(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|induction induction|nmod|expression expression|amod|END_ENTITY	Edaravone inhibits the induction of iNOS gene expression at transcriptional and posttranscriptional steps in murine macrophages .
17889387	0	Edaravone	0,9	vascular_endothelial_growth_factor	37,71	Edaravone	vascular endothelial growth factor	MESH:C005435	7422	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Edaravone inhibits the expression of vascular_endothelial_growth_factor in human astrocytes exposed to hypoxia .
26535021	0	Edoxaban	0,8	Factor_Xa	22,31	Edoxaban	Factor Xa	MESH:C552171	2159	Chemical	Gene	START_ENTITY|dep|Inhibitor Inhibitor|compound|END_ENTITY	Edoxaban -LRB- Savaysa -RRB- : A Factor_Xa Inhibitor .
26856226	0	Edoxaban	0,8	Factor_Xa	182,191	Edoxaban	Factor Xa	MESH:C552171	2159	Chemical	Gene	warfarin|compound|START_ENTITY warfarin|dep|analysis analysis|nmod|trial trial|dep|Anticoagulation Anticoagulation|nmod|Generation Generation|compound|END_ENTITY	Edoxaban vs warfarin in patients with nonvalvular atrial_fibrillation in the US Food and Drug Administration approval population : An analysis from the Effective Anticoagulation with Factor_Xa Next Generation in Atrial_Fibrillation-Thrombolysis in Myocardial_Infarction 48 -LRB- ENGAGE AF-TIMI 48 -RRB- trial .
24459178	0	Edoxaban	0,8	P-glycoprotein	23,37	Edoxaban	P-glycoprotein	MESH:C552171	5243	Chemical	Gene	transport|compound|START_ENTITY transport|nmod|END_ENTITY	Edoxaban transport via P-glycoprotein is a key factor for the drug 's disposition .
26962981	0	Edoxaban	0,8	factor_Xa	19,28	Edoxaban	factor Xa	MESH:C552171	2159	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Edoxaban , a direct factor_Xa inhibitor , suppresses tissue-factor induced human platelet_aggregation and clot-bound factor_Xa in vitro : Comparison with an antithrombin-dependent factor_Xa inhibitor , fondaparinux .
21861537	0	Edoxaban	0,8	factor_xa	28,37	Edoxaban	factor Xa	MESH:C552171	2159	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Edoxaban : a new oral direct factor_xa inhibitor .
25034361	0	Edoxaban	0,8	factor_xa	43,52	Edoxaban	factor xa	MESH:C552171	2159	Chemical	Gene	START_ENTITY|dep|update update|nmod|inhibitor inhibitor|compound|END_ENTITY	Edoxaban : an update on the new oral direct factor_xa inhibitor .
20477063	0	Eicosanoids	0,11	COX-2	52,57	Eicosanoids	COX-2	MESH:D015777	4513	Chemical	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Eicosanoids in inflammation and cancer : the role of COX-2 .
21871881	0	Eicosapentaenoic_acid	0,21	IkBa	32,36	Eicosapentaenoic acid	IkBa	MESH:D015118	4792	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Eicosapentaenoic_acid regulates IkBa and prevents tubulointerstitial_injury in kidney .
16784840	0	Eicosapentaenoic_acid	0,21	Lnk	49,52	Eicosapentaenoic acid	Lnk	MESH:D015118	10019	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Eicosapentaenoic_acid inhibits TNF-alpha-induced Lnk expression in human umbilical vein endothelial cells : involvement of the PI3K/Akt pathway .
15930517	0	Eicosapentaenoic_acid	0,21	MMP-1	42,47	Eicosapentaenoic acid	MMP-1	MESH:D015118	4312	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Eicosapentaenoic_acid inhibits UV-induced MMP-1 expression in human dermal fibroblasts .
21131061	0	Eicosapentaenoic_acid	0,21	TNF-a	32,37	Eicosapentaenoic acid	TNF-a	MESH:D015118	21926(Tax:10090)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|END_ENTITY	Eicosapentaenoic_acid decreases TNF-a and protects dystrophic muscles of mdx mice from degeneration .
25697344	0	Eicosapentaenoic_acid	0,21	VEGF-A	34,40	Eicosapentaenoic acid	VEGF-A	MESH:D015118	7422	Chemical	Gene	upregulates|amod|START_ENTITY END_ENTITY|nsubj|upregulates	Eicosapentaenoic_acid upregulates VEGF-A through both GPR120 and PPARy mediated pathways in 3T3-L1 adipocytes .
20814411	0	Eicosapentaenoic_acid	0,21	adiponectin	49,60	Eicosapentaenoic acid	adiponectin	MESH:D015118	9370	Chemical	Gene	increase|amod|START_ENTITY END_ENTITY|nsubj|increase	Eicosapentaenoic_acid and rosiglitazone increase adiponectin in an additive and PPARy-dependent manner in human adipocytes .
20352620	0	Eicosapentaenoic_acid	0,21	apelin	35,41	Eicosapentaenoic acid	apelin	MESH:D015118	30878(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|secretion secretion|compound|END_ENTITY	Eicosapentaenoic_acid up-regulates apelin secretion and gene expression in 3T3-L1 adipocytes .
11562765	0	Eicosapentaenoic_acid	0,21	cyclin	32,38	Eicosapentaenoic acid	cyclin	MESH:D015118	5111	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|compound|END_ENTITY	Eicosapentaenoic_acid modulates cyclin expression and arrests cell cycle progression in human leukemic K-562 cells .
10954131	0	Eicosapentaenoic_acid	0,21	endothelin-1	57,69	Eicosapentaenoic acid	endothelin-1	MESH:D015118	281137(Tax:9913)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|release release|nmod|cells cells|amod|END_ENTITY	Eicosapentaenoic_acid reduces thrombin-evoked release of endothelin-1 in cultured bovine endothelial cells .
14567505	0	Eicosapentaenoic_acid	0,21	endothelin-1	62,74	Eicosapentaenoic acid	endothelin-1	MESH:D015118	1906	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|production production|amod|END_ENTITY	Eicosapentaenoic_acid suppresses basal and insulin-stimulated endothelin-1 production in human endothelial cells .
9569962	0	Eicosapentaenoic_acid	0,21	endothelin-1	47,59	Eicosapentaenoic acid	endothelin-1	MESH:D015118	281137(Tax:9913)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Eicosapentaenoic_acid inhibits mitogen-induced endothelin-1 production and DNA synthesis in cultured bovine mesangial cells .
23900468	0	Eicosapentaenoic_acid	0,21	insulin	31,38	Eicosapentaenoic acid	insulin	MESH:D015118	3630	Chemical	Gene	improves|nsubj|START_ENTITY improves|dobj|sensitivity sensitivity|compound|END_ENTITY	Eicosapentaenoic_acid improves insulin sensitivity and blood sugar in overweight type 2 diabetes_mellitus patients : a double-blind randomised clinical trial .
18762411	0	Eicosapentaenoic_acid	0,21	interleukin-6	31,44	Eicosapentaenoic acid	interleukin-6	MESH:D015118	3569	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Eicosapentaenoic_acid inhibits interleukin-6 production in interleukin-1beta-stimulated C6 glioma cells through peroxisome_proliferator-activated_receptor-gamma .
7923869	0	Eicosapentaenoic_acid	0,21	leukotriene_B4_receptor	43,66	Eicosapentaenoic acid	leukotriene B4 receptor	MESH:D015118	1241	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	Eicosapentaenoic_acid modulates neutrophil leukotriene_B4_receptor expression in cystic_fibrosis .
2843588	0	Eicosapentaenoic_acid	0,21	neuropeptide_Y	90,104	Eicosapentaenoic acid	neuropeptide Y	MESH:D015118	100301542(Tax:9986)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|effects effects|nmod|END_ENTITY	Eicosapentaenoic_acid inhibits vasoconstrictor - and noradrenaline-potentiating effects of neuropeptide_Y in the isolated rabbit ear .
18762411	0	Eicosapentaenoic_acid	0,21	peroxisome_proliferator-activated_receptor-gamma	112,160	Eicosapentaenoic acid	peroxisome proliferator-activated receptor-gamma	MESH:D015118	5468	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Eicosapentaenoic_acid inhibits interleukin-6 production in interleukin-1beta-stimulated C6 glioma cells through peroxisome_proliferator-activated_receptor-gamma .
12055328	0	Eicosapentaenoic_acid	0,21	peroxisome_proliferator-activated_receptor_gamma	49,97	Eicosapentaenoic acid	peroxisome proliferator-activated receptor gamma	MESH:D015118	5468	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Eicosapentaenoic_acid induces mRNA expression of peroxisome_proliferator-activated_receptor_gamma .
10102382	0	Eicosatrienoic_acid	0,19	E-cadherin	58,68	Eicosatrienoic acid	E-cadherin	CHEBI:53460	999	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Eicosatrienoic_acid -LRB- 20:3 n-9 -RRB- inhibits the expression of E-cadherin and desmoglein in human squamous_cell_carcinoma in vitro .
22110681	0	Eis	31,34	Rv2416c	36,43	Eis	Rv2416c	CHEBI:73498	885903(Tax:83332)	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Thermostable hexameric form of Eis -LRB- Rv2416c -RRB- protein of M. _ tuberculosis plays an important role for enhanced intracellular survival within macrophages .
1989620	0	Elafin	0,6	proteinase_3	32,44	Elafin	proteinase 3	MESH:D053492	5657	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Elafin is a potent inhibitor of proteinase_3 .
22736460	0	Elaidyl-sulfamide	0,17	PPARa	50,55	Elaidyl-sulfamide	PPARa	MESH:C577145	25747(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Elaidyl-sulfamide , an oleoylethanolamide-modelled PPARa agonist , reduces body weight_gain and plasma cholesterol in rats .
19958867	0	Elinogrel	307,316	P2Y12	117,122	Elinogrel	P2Y12	MESH:C549473	64805	Chemical	Gene	platelet_thromboSis|nmod|START_ENTITY ReversAl|nmod|platelet_thromboSis Safety|dep|ReversAl Safety|appos|antagonist antagonist|compound|END_ENTITY	Safety and feasibility of adjunctive antiplatelet therapy with intravenous elinogrel , a direct-acting and reversible P2Y12 ADP-receptor antagonist , before primary percutaneous intervention in patients with ST-elevation_myocardial_infarction : the Early Rapid ReversAl of platelet_thromboSis with intravenous Elinogrel before PCI to optimize reperfusion in acute Myocardial_Infarction -LRB- ERASE MI -RRB- pilot trial .
20178048	0	Elinogrel	0,9	P2Y12_receptor	24,38	Elinogrel	P2Y12 receptor	MESH:C549473	64805	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Elinogrel , a reversible P2Y12_receptor antagonist for the treatment of acute_coronary_syndrome and prevention of secondary thrombotic events .
25929447	0	Ellagic_Acid	0,12	Macrophage_Migration_Inhibitory_Factor	75,113	Ellagic Acid	Macrophage Migration Inhibitory Factor	MESH:D004610	4282	Chemical	Gene	Inhibits|nsubj|START_ENTITY Inhibits|dobj|Activity Activity|nmod|END_ENTITY	Ellagic_Acid , a Dietary Polyphenol , Inhibits Tautomerase Activity of Human Macrophage_Migration_Inhibitory_Factor and Its Pro-inflammatory Responses in Human Peripheral Blood Mononuclear Cells .
24877639	0	Ellagic_acid	0,12	NF-kB	17,22	Ellagic acid	NF-kB	MESH:D004610	81736(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Ellagic_acid , an NF-kB inhibitor , ameliorates renal function in experimental diabetic_nephropathy .
22350787	0	Ellagic_acid	0,12	VEGFR-2	72,79	Ellagic acid	VEGFR-2	MESH:D004610	395323(Tax:9031)	Chemical	Gene	exerts|nsubj|START_ENTITY exerts|dobj|effects effects|nmod|END_ENTITY	Ellagic_acid , a phenolic compound , exerts anti-angiogenesis effects via VEGFR-2 signaling pathway in breast_cancer .
18595134	0	Ellagic_acid	0,12	nuclear_factor_kappa_B	53,75	Ellagic acid	nuclear factor kappa B	MESH:D004610	4790	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|inhibition inhibition|nmod|END_ENTITY	Ellagic_acid induces apoptosis through inhibition of nuclear_factor_kappa_B in pancreatic_cancer cells .
697921	0	Ellipticines	0,12	aryl_hydrocarbon_hydroxylase	37,65	Ellipticines	aryl hydrocarbon hydroxylase	MESH:D004611	1544	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Ellipticines as potent inhibitors of aryl_hydrocarbon_hydroxylase : their binding to microsomal cytochromes P450 and protective effect against benzo -LRB- a -RRB- pyrene mutagenicity .
16957418	0	Elocalcitol	132,143	vitamin_D_receptor	96,114	Elocalcitol	vitamin D receptor	MESH:C487049	7421	Chemical	Gene	BXL-628|appos|START_ENTITY BXL-628|compound|END_ENTITY	Pre-clinical evidence and clinical translation of benign_prostatic_hyperplasia treatment by the vitamin_D_receptor agonist BXL-628 -LRB- Elocalcitol -RRB- .
20625944	0	Embelin	0,7	XIAP	53,57	Embelin	XIAP	MESH:C010945	331	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|down-regulation down-regulation|nmod|END_ENTITY	Embelin induces apoptosis through down-regulation of XIAP in human leukemia cells .
26732982	0	Embelin	0,7	neuroserpin	23,34	Embelin	neuroserpin	MESH:C010945	5274	Chemical	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Embelin binds to human neuroserpin and impairs its polymerisation .
26376435	0	Embelin	22,29	p53	68,71	Embelin	p53	MESH:C010945	7157	Chemical	Gene	Activation|compound|START_ENTITY Activation|nmod|END_ENTITY	Targeting Mortalin by Embelin Causes Activation of Tumor Suppressor p53 and Deactivation of Metastatic Signaling in Human Breast_Cancer Cells .
22649478	0	Emodin	0,6	AMP-Activated_Protein_Kinase	95,123	Emodin	AMP-Activated Protein Kinase	MESH:D004642	78975(Tax:10116)	Chemical	Gene	Ameliorates|nsubj|START_ENTITY Ameliorates|nmod|END_ENTITY	Emodin , a Naturally Occurring Anthraquinone Derivative , Ameliorates Dyslipidemia by Activating AMP-Activated_Protein_Kinase in High-Fat-Diet-Fed Rats .
26131983	0	Emodin	0,6	C-Reactive_Protein	37,55	Emodin	C-Reactive Protein	MESH:D004642	25419(Tax:10116)	Chemical	Gene	Generation|compound|START_ENTITY Generation|compound|END_ENTITY	Emodin Inhibits Homocysteine-Induced C-Reactive_Protein Generation in Vascular Smooth Muscle Cells by Regulating PPARy Expression and ROS-ERK1 / 2/p38 Signal Pathway .
23046742	0	Emodin	0,6	ERCC1	15,20	Emodin	ERCC1	MESH:D004642	2067	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|expression expression|nummod|END_ENTITY	Emodin affects ERCC1 expression in breast_cancer cells .
24028150	0	Emodin	0,6	IL-1b	28,33	Emodin	IL-1b	MESH:D004642	24494(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|compound|END_ENTITY	Emodin inhibits ATP-induced IL-1b secretion , ROS production and phagocytosis attenuation in rat peritoneal macrophages via antagonizing P2X receptor .
16959273	0	Emodin	0,6	MMP-1	34,39	Emodin	MMP-1	MESH:D004642	4312	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Emodin inhibits TNF_alpha-induced MMP-1 expression through suppression of activator_protein-1 -LRB- AP-1 -RRB- .
9780008	0	Emodin	0,6	NF-kappaB	69,78	Emodin	NF-kappaB	MESH:D004642	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	Emodin -LRB- 3-methyl-1 ,6,8 - trihydroxyanthraquinone -RRB- inhibits TNF-induced NF-kappaB activation , IkappaB degradation , and expression of cell surface adhesion proteins in human vascular endothelial cells .
17174269	0	Emodin	0,6	PPARgamma	12,21	Emodin	PPARgamma	MESH:D004642	19016(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Emodin with PPARgamma ligand-binding activity promotes adipocyte differentiation and increases glucose uptake in 3T3-Ll cells .
26628989	0	Emodin	0,6	SIRT1	85,90	Emodin	SIRT1	MESH:D004642	23411	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|regulating regulating|dobj|END_ENTITY	Emodin inhibits HMGB1-induced tumor angiogenesis in human osteosarcoma by regulating SIRT1 .
26524020	0	Emodin	11,17	TGF-b	93,98	Emodin	TGF-b	MESH:D004642	7040	Chemical	Gene	Effect|nmod|START_ENTITY Effect|acl|END_ENTITY	-LSB- Effect of Emodin Combined with AZT on the Proliferation and the Expression of BCL-2 , NF-kB , TGF-b in the Leukemia Stem Cells-KG-1a cells -RSB- .
24140264	0	Emodin	0,6	TGF-b1	39,45	Emodin	TGF-b1	MESH:D004642	7040	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|END_ENTITY	Emodin attenuates high glucose-induced TGF-b1 and fibronectin expression in mesangial cells through inhibition of NF-kB pathway .
10083837	0	Emodin	0,6	casein_kinase_II	119,135	Emodin	casein kinase II	MESH:D004642	1457	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	Emodin , an anthraquinone derivative isolated from the rhizomes of Rheum palmatum , selectively inhibits the activity of casein_kinase_II as a competitive inhibitor .
25064046	0	Emodin	0,6	inducible_nitric_oxide_synthase	16,47	Emodin	inducible nitric oxide synthase	MESH:D004642	24599(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Emodin inhibits inducible_nitric_oxide_synthase in a rat model of craniocerebral_explosive_injury .
19357036	0	Emodin	0,6	stromal_derived_factor-1	40,64	Emodin	stromal derived factor-1	MESH:D004642	24772(Tax:10116)	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|expression expression|amod|END_ENTITY	Emodin and baicalein inhibit pancreatic stromal_derived_factor-1 expression in rats with acute pancreatitis .
23588681	0	Emodin-6-O-b-D-glucoside	0,24	endothelial_protein_C_receptor	40,70	Emodin-6-O-b-D-glucoside	endothelial protein C receptor	null	10544	Chemical	Gene	down-regulates|amod|START_ENTITY END_ENTITY|nsubj|down-regulates	Emodin-6-O-b-D-glucoside down-regulates endothelial_protein_C_receptor shedding .
21985634	0	Empagliflozin	0,13	SGLT-2	127,133	Empagliflozin	SGLT-2	MESH:C570240	6524	Chemical	Gene	START_ENTITY|dep|characterisation characterisation|nmod|inhibitors inhibitors|compound|END_ENTITY	Empagliflozin , a novel selective sodium_glucose cotransporter-2 -LRB- SGLT-2 -RRB- inhibitor : characterisation and comparison with other SGLT-2 inhibitors .
21985634	0	Empagliflozin	0,13	SGLT-2	65,71	Empagliflozin	SGLT-2	MESH:C570240	6524	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|appos|END_ENTITY	Empagliflozin , a novel selective sodium_glucose cotransporter-2 -LRB- SGLT-2 -RRB- inhibitor : characterisation and comparison with other SGLT-2 inhibitors .
22268612	0	Empagliflozin	0,13	SGLT-2	44,50	Empagliflozin	SGLT-2	MESH:C570240	64522(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Empagliflozin , a novel potent and selective SGLT-2 inhibitor , improves glycaemic control alone and in combination with insulin in streptozotocin-induced diabetic rats , a model of type_1_diabetes_mellitus .
24991224	0	Empagliflozin	0,13	SGLT2	54,59	Empagliflozin	SGLT2	MESH:C570240	6524	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|appos|END_ENTITY	Empagliflozin : a new sodium-glucose_co-transporter_2 -LRB- SGLT2 -RRB- inhibitor for the treatment of type 2 diabetes .
25712444	0	Empagliflozin	0,13	SGLT2	18,23	Empagliflozin	SGLT2	MESH:C570240	6524	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|compound|END_ENTITY	Empagliflozin , an SGLT2 Inhibitor for the Treatment of Type_2_Diabetes_Mellitus : A Review of the Evidence .
25813264	0	Empagliflozin	1,14	SGLT2	44,49	Empagliflozin	SGLT2	MESH:C570240	6524	Chemical	Gene	START_ENTITY|dep|representative representative|nmod|inhibitors inhibitors|nummod|END_ENTITY	-LSB- Empagliflozin - the new representative of SGLT2 transporter inhibitors for the treatment of patients with diabetes 2 type -RSB- .
26045645	0	Empagliflozin	0,13	SGLT2	35,40	Empagliflozin	SGLT2	MESH:C570240	6524	Chemical	Gene	START_ENTITY|dep|Inhibitor Inhibitor|compound|END_ENTITY	Empagliflozin -LRB- Jardiance -RRB- : A Novel SGLT2 Inhibitor for the Treatment of Type-2 Diabetes .
26629271	0	Empagliflozin	11,24	SGLT2	30,35	Empagliflozin	SGLT2	MESH:C570240	6524	Chemical	Gene	Jardiance|appos|START_ENTITY Jardiance|appos|Inhibitor Inhibitor|compound|END_ENTITY	Jardiance -LRB- Empagliflozin -RRB- , an SGLT2 Inhibitor , Receives FDA Approval for the Treatment of Patients with Type 2 Diabetes .
26807719	0	Empagliflozin	15,28	SGLT2	33,38	Empagliflozin	SGLT2	MESH:C570240	246787(Tax:10090)	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|compound|END_ENTITY	The Effects of Empagliflozin , an SGLT2 Inhibitor , on Pancreatic b-Cell Mass and Glucose Homeostasis in Type 1 Diabetes .
25611208	0	Empagliflozin	0,13	Sodium-Glucose_Cotransporter_2	31,61	Empagliflozin	Sodium-Glucose Cotransporter 2	MESH:C570240	64522(Tax:10116)	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|nmod|END_ENTITY	Empagliflozin , an Inhibitor of Sodium-Glucose_Cotransporter_2 Exerts Anti-Inflammatory and Antifibrotic Effects on Experimental Diabetic_Nephropathy Partly by Suppressing AGEs-Receptor Axis .
24991224	0	Empagliflozin	0,13	sodium-glucose_co-transporter_2	21,52	Empagliflozin	sodium-glucose co-transporter 2	MESH:C570240	6524	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Empagliflozin : a new sodium-glucose_co-transporter_2 -LRB- SGLT2 -RRB- inhibitor for the treatment of type 2 diabetes .
26541949	0	Empagliflozin	0,13	sodium-glucose_cotransporter_2	17,47	Empagliflozin	sodium-glucose cotransporter 2	MESH:C570240	6524	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Empagliflozin : A sodium-glucose_cotransporter_2 inhibitor for treatment of type 2 diabetes .
18692133	0	Emtricitabine	0,13	multidrug_resistance_associated_protein	42,81	Emtricitabine	multidrug resistance associated protein	MESH:C122114	8714	Chemical	Gene	START_ENTITY|dep|Inhibitor Inhibitor|nmod|END_ENTITY	Emtricitabine : Inhibitor and substrate of multidrug_resistance_associated_protein .
6089307	0	Enalapril	0,9	angiotensin-converting-enzyme	104,133	Enalapril	angiotensin-converting-enzyme	MESH:D004656	1636	Chemical	Gene	START_ENTITY|dep|effects effects|nmod|END_ENTITY	Enalapril and lisinopril in renovascular_hypertension -- antihypertensive and hormonal effects of two new angiotensin-converting-enzyme -LRB- ACE -RRB- inhibitors .
2982541	0	Enalapril	0,9	angiotensin-converting_enzyme	27,56	Enalapril	angiotensin-converting enzyme	MESH:D004656	1636	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Enalapril , a nonsulfhydryl angiotensin-converting_enzyme inhibitor .
1566884	0	Enalapril	0,9	elastin	44,51	Enalapril	elastin	MESH:D004656	25043(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|accumulation accumulation|nmod|END_ENTITY	Enalapril suppresses normal accumulation of elastin and collagen in cardiovascular tissues of growing rats .
21423293	0	Enalapril	0,9	endothelin-1	95,107	Enalapril	endothelin-1	MESH:D004656	24323(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|advcl|affecting affecting|dobj|expression expression|acl|END_ENTITY	Enalapril decreases cardiac mass and fetal gene expression without affecting the expression of endothelin-1 , transforming_growth_factor_b-1 , or cardiotrophin-1 in the healthy normotensive rat .
7645558	0	Enalapril	0,9	erythropoietin	90,104	Enalapril	erythropoietin	MESH:D004656	2056	Chemical	Gene	treatment|amod|START_ENTITY treatment|dep|independent independent|acl|circulating circulating|dobj|levels levels|compound|END_ENTITY	Enalapril treatment of posttransplant erythrocytosis : efficacy independent of circulating erythropoietin levels .
2560316	0	Enalapril	0,9	prolactin	27,36	Enalapril	prolactin	MESH:D004656	24683(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|levels levels|compound|END_ENTITY	Enalapril decreases plasma prolactin levels in hypertensive patients .
26586345	0	Encorafenib	0,11	BRAF	31,35	Encorafenib	BRAF	MESH:C000601108	673	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Encorafenib -LRB- LGX818 -RRB- , a potent BRAF inhibitor , induces senescence accompanied by autophagy in BRAFV600E melanoma cells .
16131814	1	Endocannabinoids	107,123	CB1	134,137	Endocannabinoids	CB1	MESH:D063388	12801(Tax:10090)	Chemical	Gene	START_ENTITY|acl|acting acting|nmod|receptors receptors|nummod|END_ENTITY	Endocannabinoids acting at CB1 cannabinoid receptors -LRB- CB1 -RRB- increase appetite .
17272273	0	Endofin	0,7	Smad4	47,52	Endofin	Smad4	null	4089	Chemical	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Endofin , a FYVE domain protein , interacts with Smad4 and facilitates transforming_growth_factor-beta signaling .
10657505	0	Endomorphin-1	0,13	fos	42,45	Endomorphin-1	fos	MESH:C105293	314322(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|compound|END_ENTITY	Endomorphin-1 reduces carrageenan-induced fos expression in the rat spinal dorsal horn .
20156196	1	Endostatin	95,105	TG-2	157,161	Endostatin	TG-2	MESH:D043169	7052	Chemical	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Endostatin , a C-terminal fragment of collagen XVIII , binds to TG-2 -LRB- transglutaminase-2 -RRB- in a cation-dependent manner .
20846515	0	Endostatin	0,10	nerve_growth_factor	17,36	Endostatin	nerve growth factor	MESH:D043169	310738(Tax:10116)	Chemical	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Endostatin binds nerve_growth_factor and thereby inhibits neurite outgrowth and neuronal migration in-vitro .
25199686	0	Endosulfan	0,10	COX-2	19,24	Endosulfan	COX-2	MESH:D004726	19225(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Endosulfan induces COX-2 expression via NADPH oxidase and the ROS , MAPK , and Akt pathways .
14575683	0	Endosulfan	0,10	malate_dehydrogenase	29,49	Endosulfan	malate dehydrogenase	MESH:D004726	4200	Chemical	Gene	effects|compound|START_ENTITY effects|nmod|END_ENTITY	Endosulfan effects on muscle malate_dehydrogenase of the freshwater catfish Clarias batrachus .
7849246	0	Endothelin	0,10	ETA	91,94	Endothelin	ETA	MESH:D016232	24326(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|END_ENTITY	Endothelin stimulates mitogen-activated protein kinase activity in mesangial cells through ETA .
11754215	0	Endothelin	0,10	GLAST	51,56	Endothelin	GLAST	MESH:D016232	6507	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	Endothelin downregulates the glutamate transporter GLAST in cAMP-differentiated astrocytes in vitro .
7929159	0	Endothelin	0,10	Shc	68,71	Endothelin	Shc	MESH:D016232	6464	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Endothelin induces tyrosine phosphorylation and GRB2 association of Shc in astrocytes .
2172556	0	Endothelin	0,10	angiotensin_I	22,35	Endothelin	angiotensin I	MESH:D016232	183	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Endothelin stimulates angiotensin_I to angiotensin_II conversion in cultured pulmonary artery endothelial cells .
2141098	0	Endothelin	0,10	atrial_natriuretic_factor	33,58	Endothelin	atrial natriuretic factor	MESH:D016232	24602(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|nmod|END_ENTITY	Endothelin stimulates release of atrial_natriuretic_factor in anesthetized rats .
1831328	0	Endothelin	0,10	atrial_natriuretic_peptide	52,78	Endothelin	atrial natriuretic peptide	MESH:D016232	24602(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|synthesis synthesis|nmod|END_ENTITY	Endothelin increases the synthesis and secretion of atrial_natriuretic_peptide in neonatal rat cardiocytes .
2136728	0	Endothelin	0,10	atrial_natriuretic_peptide	48,74	Endothelin	atrial natriuretic peptide	MESH:D016232	24602(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|amod|END_ENTITY	Endothelin stimulates basal and stretch-induced atrial_natriuretic_peptide secretion from the perfused rat heart .
2163306	0	Endothelin	0,10	atrial_natriuretic_peptide	33,59	Endothelin	atrial natriuretic peptide	MESH:D016232	24602(Tax:10116)	Chemical	Gene	START_ENTITY|dep|stimulus stimulus|nmod|secretion secretion|amod|END_ENTITY	Endothelin : a potent stimulus of atrial_natriuretic_peptide secretion by superfused rat atria and its dependency on calcium .
2458103	0	Endothelin	0,10	atrial_natriuretic_peptide	40,66	Endothelin	atrial natriuretic peptide	MESH:D016232	24602(Tax:10116)	Chemical	Gene	secretagogue|nsubj|START_ENTITY secretagogue|nmod|END_ENTITY	Endothelin is a potent secretagogue for atrial_natriuretic_peptide in cultured rat atrial myocytes .
7503296	0	Endothelin	0,10	atrial_natriuretic_peptide	60,86	Endothelin	atrial natriuretic peptide	MESH:D016232	4878	Chemical	Gene	acts|nsubj|START_ENTITY acts|nmod|regulator regulator|nmod|release release|compound|END_ENTITY	Endothelin acts as a paracrine regulator of stretch-induced atrial_natriuretic_peptide release .
3139457	0	Endothelin	0,10	c-fos	22,27	Endothelin	c-fos	MESH:D016232	314322(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Endothelin stimulates c-fos and c-myc expression and proliferation of vascular smooth muscle cells .
15113749	0	Endothelin	0,10	endothelial_nitric_oxide_synthase	22,55	Endothelin	endothelial nitric oxide synthase	MESH:D016232	4846	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Endothelin stimulates endothelial_nitric_oxide_synthase expression in the thick ascending limb .
10402223	0	Endothelin	0,10	p125FAK	50,57	Endothelin	p125FAK	MESH:D016232	25614(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Endothelin stimulates tyrosine phosphorylation of p125FAK and p130Cas in rat cerebral cortex .
8344196	0	Endothelin	0,10	prolactin	52,61	Endothelin	prolactin	MESH:D016232	5617	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|nmod|END_ENTITY	Endothelin inhibits basal and stimulated release of prolactin by human decidual cells .
9488241	0	Endothelin	0,10	renin	22,27	Endothelin	renin	MESH:D016232	5972	Chemical	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	Endothelin and active renin levels in essential hypertension and hypertension with renal_artery_stenosis before and after percutaneous transluminal renal angioplasty .
8897839	0	Endotoxin	0,9	HSP70	26,31	Endotoxin	HSP70	null	266759(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Endotoxin induces cardiac HSP70 and resistance to endotoxemic_myocardial_depression in rats .
1848608	0	Endotoxin	0,9	angiotensin-converting_enzyme	83,112	Endotoxin	angiotensin-converting enzyme	null	24310(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|nmod|END_ENTITY	Endotoxin reduces specific pulmonary uptake of radiolabeled monoclonal antibody to angiotensin-converting_enzyme .
8190518	0	Endotoxin	0,9	glutathione_reductase	18,39	Endotoxin	glutathione reductase	null	14782(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|activity activity|amod|END_ENTITY	Endotoxin induces glutathione_reductase activity in lungs of mice .
14551234	0	Endotoxin	0,9	gonadotropin-releasing_hormone	42,72	Endotoxin	gonadotropin-releasing hormone	null	2796	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|nmod|END_ENTITY	Endotoxin inhibits the surge secretion of gonadotropin-releasing_hormone via a prostaglandin-independent pathway .
1423908	0	Endotoxin	0,9	interleukin-6	21,34	Endotoxin	interleukin-6	null	3569	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|amod|END_ENTITY	Endotoxin stimulates interleukin-6 production by human Kupffer cells .
7986158	0	Endotoxin	0,9	interleukin-6	21,34	Endotoxin	interleukin-6	null	24498(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|amod|END_ENTITY	Endotoxin stimulates interleukin-6 production in intestinal epithelial cells .
8564528	0	Endotoxin	0,9	interleukin-6	32,45	Endotoxin	interleukin-6	null	24498(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Endotoxin induced production of interleukin-6 is enhanced by vitamin_E deficiency and reduced by black tea extract .
12629120	0	Endotoxin	0,9	leptin	21,27	Endotoxin	leptin	null	3952	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Endotoxin stimulates leptin in the human and nonhuman primate .
15727690	0	Endotoxin	11,20	peroxisome_proliferator-activated_receptor_alpha	42,90	Endotoxin	peroxisome proliferator-activated receptor alpha	null	25747(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of Endotoxin on the expression of peroxisome_proliferator-activated_receptor_alpha in the development of nonalcoholic_steatohepatitis in rats -RSB- .
17008589	0	Endotoxin	0,9	toll-like_receptor_4	18,38	Endotoxin	toll-like receptor 4	null	7099	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Endotoxin induces toll-like_receptor_4 expression in vascular smooth muscle cells via NADPH oxidase activation and mitogen-activated protein kinase signaling pathways .
9200478	0	Endotoxin	0,9	type_II_phospholipase_A2	32,56	Endotoxin	type II phospholipase A2	null	100135599(Tax:10141)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Endotoxin induces expression of type_II_phospholipase_A2 in macrophages during acute_lung_injury in guinea_pigs : involvement of TNF-alpha in lipopolysaccharide-induced type_II_phospholipase_A2 synthesis .
21148080	0	Endoxifen	0,9	P-glycoprotein	88,102	Endoxifen	P-glycoprotein	MESH:C055492	5243	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Endoxifen , the active metabolite of tamoxifen , is a substrate of the efflux transporter P-glycoprotein -LRB- multidrug_resistance_1 -RRB- .
16531327	0	Engystol	39,47	interferon-gamma	51,67	Engystol	interferon-gamma	null	3458	Chemical	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Effects of the homeopathic preparation Engystol on interferon-gamma production by human T-lymphocytes .
10561307	0	Eniluracil	0,10	dihydropyrimidine_dehydrogenase	44,75	Eniluracil	dihydropyrimidine dehydrogenase	MESH:C073482	1806	Chemical	Gene	treatment|amod|START_ENTITY inactivates|nsubj|treatment inactivates|dobj|END_ENTITY	Eniluracil treatment completely inactivates dihydropyrimidine_dehydrogenase in colorectal_tumors .
11060767	0	Eniluracil	0,10	dihydropyrimidine_dehydrogenase	41,72	Eniluracil	dihydropyrimidine dehydrogenase	MESH:C073482	1806	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	Eniluracil : an irreversible inhibitor of dihydropyrimidine_dehydrogenase .
1679665	0	Enkephalin	0,10	biotinidase	37,48	Enkephalin	biotinidase	MESH:D004745	686	Chemical	Gene	hydrolysis|nsubj|START_ENTITY hydrolysis|nmod|END_ENTITY	Enkephalin hydrolysis by human serum biotinidase .
218204	0	Enkephalin	0,10	substance_P	31,42	Enkephalin	substance P	MESH:D004745	6863	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|nmod|END_ENTITY	Enkephalin inhibits release of substance_P from sensory neurons in culture and decreases action potential duration .
7503804	0	Enoxacin	0,8	CYP1A2	26,32	Enoxacin	CYP1A2	MESH:D015365	24297(Tax:10116)	Chemical	Gene	inducer|nsubj|START_ENTITY inducer|nmod|END_ENTITY	Enoxacin is an inducer of CYP1A2 in rat liver .
11940541	0	Enoxaparin	0,10	antithrombin	25,37	Enoxaparin	antithrombin	MESH:D017984	462	Chemical	Gene	START_ENTITY|nmod|therapy therapy|compound|END_ENTITY	Enoxaparin as adjunctive antithrombin therapy for ST-elevation myocardial_infarction : results of the ENTIRE-Thrombolysis in Myocardial_Infarction -LRB- TIMI -RRB- 23 Trial .
11440283	0	Entacapone	0,10	catechol-O-methyltransferase	14,42	Entacapone	catechol-O-methyltransferase	MESH:C071192	1312	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Entacapone : a catechol-O-methyltransferase inhibitor for the adjunctive treatment of Parkinson 's _ disease .
15992091	0	Entacapone	0,10	catechol-O-methyltransferase	14,42	Entacapone	catechol-O-methyltransferase	MESH:C071192	1312	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Entacapone , a catechol-O-methyltransferase inhibitor for treating Parkinson 's _ disease : review and current status .
19879254	0	Entacapone	0,10	catechol-O-methyltransferase	14,42	Entacapone	catechol-O-methyltransferase	MESH:C071192	24267(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Entacapone , a catechol-O-methyltransferase inhibitor , improves the motor activity and dopamine content of basal ganglia in a rat model of Parkinson 's _ disease induced by Japanese_encephalitis_virus .
9537825	0	Entacapone	0,10	catechol-O-methyltransferase	20,48	Entacapone	catechol-O-methyltransferase	MESH:C071192	12846(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Entacapone , a novel catechol-O-methyltransferase inhibitor for Parkinson 's _ disease , does not impair mitochondrial energy production .
20150427	0	Entacapone	0,10	catechol_O-methyltransferase	30,58	Entacapone	catechol O-methyltransferase	MESH:C071192	1312	Chemical	Gene	START_ENTITY|appos|inhibitors inhibitors|amod|END_ENTITY	Entacapone and tolcapone , two catechol_O-methyltransferase inhibitors , block fibril formation of alpha-synuclein and beta-amyloid and protect against amyloid-induced toxicity .
25224377	0	Entecavir	0,9	furin	24,29	Entecavir	furin	MESH:C413685	5045	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|compound|END_ENTITY	Entecavir combined with furin inhibitor simultaneously reduces hepatitis_B_virus replication and e antigen secretion .
12779078	0	Enterolactone	0,13	EGF	53,56	Enterolactone	EGF	MESH:C029497	1950	Chemical	Gene	START_ENTITY|dep|correlation correlation|nmod|END_ENTITY	Enterolactone in breast_cyst fluid : correlation with EGF and breast_cancer risk .
18567745	0	Enterolactone	0,13	heme_oxygenase-1	22,38	Enterolactone	heme oxygenase-1	MESH:C029497	3162	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Enterolactone induces heme_oxygenase-1 expression through nuclear_factor-E2-related_factor_2 activation in endothelial cells .
19211828	0	Enterolactone	0,13	insulin-like_growth_factor-1_receptor	23,60	Enterolactone	insulin-like growth factor-1 receptor	MESH:C029497	3480	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Enterolactone inhibits insulin-like_growth_factor-1_receptor signaling in human prostatic_carcinoma PC-3 cells .
18567745	0	Enterolactone	0,13	nuclear_factor-E2-related_factor_2	58,92	Enterolactone	nuclear factor-E2-related factor 2	MESH:C029497	4780	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|amod|END_ENTITY	Enterolactone induces heme_oxygenase-1 expression through nuclear_factor-E2-related_factor_2 activation in endothelial cells .
15713687	0	Enterostatin	0,12	UCP2	47,51	Enterostatin	UCP2	null	54315(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|levels levels|compound|END_ENTITY	Enterostatin decreases postprandial pancreatic UCP2 mRNA levels and increases plasma insulin and amylin .
24451109	3	Enzalutamide	373,385	AR	390,392	Enzalutamide	AR	MESH:C540278	367	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Enzalutamide , an AR inhibitor that impairs nuclear localization of AR , was used to elucidate the role of AR in preclinical models of ER positive and negative breast_cancer .
25484141	0	Enzalutamide	73,85	Androgen_Receptor	14,31	Enzalutamide	Androgen Receptor	MESH:C540278	367	Chemical	Gene	Targeting|nmod|START_ENTITY Targeting|dobj|Confers Confers|compound|END_ENTITY	Targeting the Androgen_Receptor Confers In Vivo Cross-resistance Between Enzalutamide and Docetaxel , But Not Cabazitaxel , in Castration-resistant Prostate_Cancer .
25713333	0	Enzalutamide	113,125	Androgen_Receptor	80,97	Enzalutamide	Androgen Receptor	MESH:C540278	367	Chemical	Gene	Subtypes|acl|START_ENTITY Subtypes|nmod|Rely Rely|nmod|END_ENTITY	Multiple Molecular Subtypes of Triple-Negative Breast_Cancer Critically Rely on Androgen_Receptor and Respond to Enzalutamide In Vivo .
26215602	1	Enzalutamide	148,160	Androgen_Receptor	89,106	Enzalutamide	Androgen Receptor	MESH:C540278	367	Chemical	Gene	Targeting|nmod|START_ENTITY Targeting|dobj|Confers Confers|compound|END_ENTITY	Targeting the Androgen_Receptor Confers In Vivo Cross-resistance Between Enzalutamide and Docetaxel , But Not Cabazitaxel , in Castration-resistant Prostate_Cancer .
26233533	1	Enzalutamide	213,225	Androgen_Receptor	154,171	Enzalutamide	Androgen Receptor	MESH:C540278	367	Chemical	Gene	Targeting|nmod|START_ENTITY Targeting|dobj|Confers Confers|compound|END_ENTITY	Targeting the Androgen_Receptor Confers In Vivo Cross-resistance Between Enzalutamide and Docetaxel , But Not Cabazitaxel , in Castration-resistant Prostate_Cancer .
26857528	0	Enzalutamide	82,94	Androgen_Receptor	107,124	Enzalutamide	Androgen Receptor	MESH:C540278	367	Chemical	Gene	START_ENTITY|nmod|V7 V7|compound|END_ENTITY	Potential Role for YB-1 in Castration-Resistant Prostate Cancer and Resistance to Enzalutamide Through the Androgen_Receptor V7 .
26857528	0	Enzalutamide	82,94	YB-1	19,23	Enzalutamide	YB-1	MESH:C540278	4904	Chemical	Gene	Role|acl|START_ENTITY Role|nmod|END_ENTITY	Potential Role for YB-1 in Castration-Resistant Prostate Cancer and Resistance to Enzalutamide Through the Androgen_Receptor V7 .
23341368	0	Enzalutamide	0,12	androgen_receptor	34,51	Enzalutamide	androgen receptor	MESH:C540278	367	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Enzalutamide , a second generation androgen_receptor antagonist : development and clinical applications in prostate_cancer .
25638257	0	Enzalutamide	0,12	androgen_receptor	65,82	Enzalutamide	androgen receptor	MESH:C540278	367	Chemical	Gene	START_ENTITY|dep|prostate_cancer prostate_cancer|acl|targeted targeted|dobj|therapy therapy|nmod|END_ENTITY	Enzalutamide : A new prostate_cancer targeted therapy against the androgen_receptor .
19913408	0	Enzastaurin	0,11	H2AX	20,24	Enzastaurin	H2AX	MESH:C504878	3014	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Enzastaurin induces H2AX phosphorylation to regulate apoptosis via MAPK signalling in malignant_glioma cells .
19043530	0	Enzastaurin	0,11	PKCbeta	29,36	Enzastaurin	PKCbeta	MESH:C504878	5579	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Enzastaurin , an inhibitor of PKCbeta , Enhances Antiangiogenic Effects and Cytotoxicity of Radiation against Endothelial Cells .
24924767	0	Eomesodermin	9,21	nodal	40,45	Eomesodermin	nodal	null	18119(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Maternal Eomesodermin regulates zygotic nodal gene expression for mesendoderm induction in zebrafish embryos .
7530047	0	Eosin	0,5	Na-Ca_exchanger	87,102	Eosin	Na-Ca exchanger	MESH:D004801	6546	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|END_ENTITY	Eosin , a potent inhibitor of the plasma membrane Ca pump , does not inhibit the cardiac Na-Ca_exchanger .
11004584	0	Eosin	0,5	alpha-synuclein	21,36	Eosin	alpha-synuclein	MESH:D004801	6622	Chemical	Gene	interaction|compound|START_ENTITY interaction|nmod|END_ENTITY	Eosin interaction of alpha-synuclein leading to protein self-oligomerization .
10706854	0	Eotaxin	0,7	ERK2	86,90	Eotaxin	ERK2	null	5594	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Eotaxin induces degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen-activated protein kinases .
26990117	0	Epacadostat	131,142	IDO1	147,151	Epacadostat	IDO1	null	3620	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|compound|END_ENTITY	Potential Under-Prediction of Warfarin Drug Interaction from Conventional Interaction Studies _ Risk Mitigation : A Case Study with Epacadostat , an IDO1 Inhibitor .
23416460	0	Ephedrine	0,9	thioredoxin-1	18,31	Ephedrine	thioredoxin-1	MESH:D004809	116484(Tax:10116)	Chemical	Gene	START_ENTITY|acl|induced induced|dobj|expression expression|amod|END_ENTITY	Ephedrine induced thioredoxin-1 expression through b-adrenergic receptor/cyclic _ AMP/protein kinase A/dopamine - and cyclic_AMP-regulated phosphoprotein signaling pathway .
8632316	0	Epibatidine	0,11	nicotinic_acetylcholine_receptor	15,47	Epibatidine	nicotinic acetylcholine receptor	MESH:C082748	170945(Tax:10116)	Chemical	Gene	START_ENTITY|dep|agonist agonist|compound|END_ENTITY	Epibatidine : a nicotinic_acetylcholine_receptor agonist releases monoaminergic neurotransmitters : in vitro and in vivo evidence in rats .
19300393	0	Epicatechin	0,11	IL-6	23,27	Epicatechin	IL-6	MESH:D002392	3569	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|production production|amod|END_ENTITY	Epicatechin suppresses IL-6 , IL-8 and enhances IL-10 production with NF-kappaB nuclear translocation in whole blood stimulated system .
18586007	0	Epigallocatechin	0,16	haem_oxygenase-1	27,43	Epigallocatechin	haem oxygenase-1	MESH:C057580	3162	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|amod|END_ENTITY	Epigallocatechin activates haem_oxygenase-1 expression via protein kinase Cdelta and Nrf2 .
24353864	0	Epigallocatechin-3-Gallate	10,36	MUC5B	52,57	Epigallocatechin-3-Gallate	MUC5B	MESH:C045651	727897	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|Expression Expression|compound|END_ENTITY	Effect of Epigallocatechin-3-Gallate on PMA-Induced MUC5B Expression in Human Airway Epithelial Cells .
26968114	0	Epigallocatechin-3-Gallate	0,26	Myeloperoxidase	41,56	Epigallocatechin-3-Gallate	Myeloperoxidase	MESH:C045651	17523(Tax:10090)	Chemical	Gene	Inhibition|compound|START_ENTITY Inhibition|nmod|END_ENTITY	Epigallocatechin-3-Gallate Inhibition of Myeloperoxidase and Its Counter-Regulation by Dietary Iron and Lipocalin_2 in Murine Model of Gut Inflammation .
22111071	0	Epigallocatechin-3-Gallate	11,37	TGF-b1	59,65	Epigallocatechin-3-Gallate	TGF-b1	MESH:C045651	7040	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of Epigallocatechin-3-Gallate on the Expression of TGF-b1 , PKC_a / bII , and NF-kB in High-Glucose-Stimulated Glomerular Epithelial Cells .
26754091	0	Epigallocatechin-3-O-gallate	0,28	microRNA-let-7b	42,57	Epigallocatechin-3-O-gallate	microRNA-let-7b	MESH:C045651	406884	Chemical	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|amod|END_ENTITY	Epigallocatechin-3-O-gallate up-regulates microRNA-let-7b expression by activating 67-kDa_laminin_receptor signaling in melanoma cells .
18397796	0	Epigallocatechin-3-O-gallate	0,28	monocyte_chemotactic_protein-1	55,85	Epigallocatechin-3-O-gallate	monocyte chemotactic protein-1	CHEBI:4806	281043(Tax:9913)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Epigallocatechin-3-O-gallate inhibits TNFalpha-induced monocyte_chemotactic_protein-1 production from vascular endothelial cells .
24039182	0	Epigallocatechin-3-gallate	0,26	DYRK1A	30,36	Epigallocatechin-3-gallate	DYRK1A	MESH:C045651	13548(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Epigallocatechin-3-gallate , a DYRK1A inhibitor , rescues cognitive_deficits in Down syndrome_mouse models and in humans .
20537126	0	Epigallocatechin-3-gallate	0,26	HSP70	56,61	Epigallocatechin-3-gallate	HSP70	MESH:C045651	3308	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|nmod|END_ENTITY	Epigallocatechin-3-gallate suppresses the expression of HSP70 and HSP90 and exhibits anti-tumor activity in vitro and in vivo .
23884787	0	Epigallocatechin-3-gallate	0,26	Kruppel-like_factor_4	55,76	Epigallocatechin-3-gallate	Kruppel-like factor 4	MESH:C045651	9314	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Epigallocatechin-3-gallate regulates the expression of Kruppel-like_factor_4 through myocyte enhancer factor 2A .
23912478	0	Epigallocatechin-3-gallate	0,26	MMP-1	55,60	Epigallocatechin-3-gallate	MMP-1	MESH:C045651	4312	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|dobj|expression expression|compound|END_ENTITY	Epigallocatechin-3-gallate prevents heat_shock-induced MMP-1 expression by inhibiting AP-1 activity in human dermal fibroblasts .
21170718	0	Epigallocatechin-3-gallate	0,26	MMP-9	60,65	Epigallocatechin-3-gallate	MMP-9	MESH:C045651	4318	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	Epigallocatechin-3-gallate -LRB- EGCG -RRB- downregulates EGF-induced MMP-9 in breast_cancer cells : involvement of integrin receptor a5b1 in the process .
18155512	0	Epigallocatechin-3-gallate	0,26	MUC5AC	62,68	Epigallocatechin-3-gallate	MUC5AC	MESH:C045651	4586	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Epigallocatechin-3-gallate inhibits interleukin-1beta-induced MUC5AC gene expression and MUC5AC secretion in normal human nasal epithelial cells .
15319365	0	Epigallocatechin-3-gallate	0,26	STAT-1	36,42	Epigallocatechin-3-gallate	STAT-1	MESH:C045651	25124(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|compound|END_ENTITY	Epigallocatechin-3-gallate inhibits STAT-1 activation and protects cardiac_myocytes from ischemia/reperfusion-induced apoptosis .
16100442	0	Epigallocatechin-3-gallate	0,26	TNF-alpha	106,115	Epigallocatechin-3-gallate	TNF-alpha	MESH:C045651	7124	Chemical	Gene	suppresses|amod|START_ENTITY suppresses|dep|,4 ,4|dep|expression expression|nmod|END_ENTITY	Epigallocatechin-3-gallate suppresses galactose-alpha1 ,4 - galactose-1beta ,4 - glucose ceramide expression in TNF-alpha stimulated human intestinal epithelial cells through inhibition of MAPKs and NF-kappaB .
17135765	0	Epigallocatechin-3-gallate	0,26	TNF-alpha	49,58	Epigallocatechin-3-gallate	TNF-alpha	MESH:C045651	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|nmod|END_ENTITY	Epigallocatechin-3-gallate inhibits secretion of TNF-alpha , IL-6 and IL-8 through the attenuation of ERK and NF-kappaB in HMC-1 cells .
25925964	0	Epigallocatechin-3-gallate	0,26	VCAM-1	36,42	Epigallocatechin-3-gallate	VCAM-1	MESH:C045651	7412	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Epigallocatechin-3-gallate inhibits VCAM-1 expression and apoptosis induction associated with LC3 expressions in TNFa-stimulated human endothelial cells .
12440226	0	Epigallocatechin-3-gallate	0,26	VEGF	37,41	Epigallocatechin-3-gallate	VEGF	MESH:C045651	7422	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|production production|amod|END_ENTITY	Epigallocatechin-3-gallate decreases VEGF production in head and neck and breast_carcinoma cells by inhibiting EGFR-related pathways of signal transduction .
17016658	0	Epigallocatechin-3-gallate	0,26	VEGF	53,57	Epigallocatechin-3-gallate	VEGF	MESH:C045651	7422	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Epigallocatechin-3-gallate inhibits the PDGF-induced VEGF expression in human vascular smooth muscle cells via blocking PDGF receptor and Erk-1 / 2 .
23087143	0	Epigallocatechin-3-gallate	0,26	angiotensin_II	36,50	Epigallocatechin-3-gallate	angiotensin II	MESH:C045651	183	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Epigallocatechin-3-gallate inhibits angiotensin_II and interleukin-6-induced C-reactive_protein production in macrophages .
21328612	0	Epigallocatechin-3-gallate	0,26	apoptosis_signal-regulating_kinase_1	88,124	Epigallocatechin-3-gallate	apoptosis signal-regulating kinase 1	MESH:C045651	4217	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|pathway pathway|amod|END_ENTITY	Epigallocatechin-3-gallate induces cell apoptosis of human chondrosarcoma cells through apoptosis_signal-regulating_kinase_1 pathway .
12507586	0	Epigallocatechin-3-gallate	0,26	c-Jun_N-terminal_kinase	130,153	Epigallocatechin-3-gallate	c-Jun N-terminal kinase	MESH:C045651	5599	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	Epigallocatechin-3-gallate selectively inhibits interleukin-1beta-induced activation of mitogen activated protein kinase subgroup c-Jun_N-terminal_kinase in human osteoarthritis chondrocytes .
24445011	0	Epigallocatechin-3-gallate	0,26	connective_tissue_growth_factor	69,100	Epigallocatechin-3-gallate	connective tissue growth factor	MESH:C045651	1490	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Epigallocatechin-3-gallate inhibits lysophosphatidic_acid-stimulated connective_tissue_growth_factor via JNK and Smad3 suppression in human gingival fibroblasts .
14701854	0	Epigallocatechin-3-gallate	0,26	epidermal_growth_factor_receptor	36,68	Epigallocatechin-3-gallate	epidermal growth factor receptor	MESH:C045651	1956	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Epigallocatechin-3-gallate inhibits epidermal_growth_factor_receptor signaling pathway .
20527725	0	Epigallocatechin-3-gallate	0,26	gelatinase-B	48,60	Epigallocatechin-3-gallate	gelatinase-B	MESH:C045651	17395(Tax:10090)	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	Epigallocatechin-3-gallate -LRB- EGCG -RRB- downregulates gelatinase-B -LRB- MMP-9 -RRB- by involvement of FAK/ERK/NFkappaB and AP-1 in the human breast_cancer cell line MDA-MB-231 .
20100497	0	Epigallocatechin-3-gallate	0,26	interleukin-6	36,49	Epigallocatechin-3-gallate	interleukin-6	MESH:C045651	24498(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Epigallocatechin-3-gallate inhibits interleukin-6 - and angiotensin_II-induced production of C-reactive protein in vascular smooth muscle cells .
15657356	0	Epigallocatechin-3-gallate	0,26	p53	144,147	Epigallocatechin-3-gallate	p53	MESH:C045651	7157	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|expression expression|nmod|END_ENTITY	Epigallocatechin-3-gallate induces apoptosis in estrogen_receptor-negative human breast_carcinoma cells via modulation in protein expression of p53 and Bax and caspase-3 activation .
25732404	0	Epigallocatechin_Gallate	0,24	67_kDa_Laminin_Receptor	111,134	Epigallocatechin Gallate	67 kDa Laminin Receptor	MESH:C045651	3921	Chemical	Gene	Suppresses|nsubj|START_ENTITY Suppresses|dobj|Activity Activity|nmod|END_ENTITY	Epigallocatechin_Gallate -LRB- EGCG -RRB- Suppresses Lipopolysaccharide-Induced Toll-like_Receptor_4 -LRB- TLR4 -RRB- Activity via 67_kDa_Laminin_Receptor -LRB- 67LR -RRB- in 3T3-L1 Adipocytes .
25732404	0	Epigallocatechin_Gallate	0,24	Toll-like_Receptor_4	70,90	Epigallocatechin Gallate	Toll-like Receptor 4	MESH:C045651	7099	Chemical	Gene	Suppresses|nsubj|START_ENTITY Suppresses|dobj|Activity Activity|compound|END_ENTITY	Epigallocatechin_Gallate -LRB- EGCG -RRB- Suppresses Lipopolysaccharide-Induced Toll-like_Receptor_4 -LRB- TLR4 -RRB- Activity via 67_kDa_Laminin_Receptor -LRB- 67LR -RRB- in 3T3-L1 Adipocytes .
14610487	0	Epigallocatechin_gallate	0,24	CD4	73,76	Epigallocatechin gallate	CD4	MESH:C045651	920	Chemical	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Epigallocatechin_gallate , the main component of tea polyphenol , binds to CD4 and interferes with gp120 binding .
24366444	0	Epigallocatechin_gallate	0,24	EGFR	92,96	Epigallocatechin gallate	EGFR	MESH:C045651	1956	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	Epigallocatechin_gallate inhibits the growth of human lung_cancer by directly targeting the EGFR signaling pathway .
17139264	0	Epigallocatechin_gallate	0,24	MMP7	53,57	Epigallocatechin gallate	MMP7	MESH:C045651	4316	Chemical	Gene	effect|nsubj|START_ENTITY effect|nmod|END_ENTITY	Epigallocatechin_gallate 's protective effect against MMP7 in recessive_dystrophic_epidermolysis_bullosa patients .
17404063	0	Epigallocatechin_gallate	0,24	NF-kappa_B	70,80	Epigallocatechin gallate	NF-kappa B	MESH:C045651	18033(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	Epigallocatechin_gallate inhibits phorbol_ester-induced activation of NF-kappa_B and CREB in mouse skin : role of p38_MAPK .
21300025	0	Epigallocatechin_gallate	0,24	mTOR	101,105	Epigallocatechin gallate	mTOR	MESH:C045651	21977(Tax:10090)	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|compound|END_ENTITY	Epigallocatechin_gallate -LRB- EGCG -RRB- , a major component of green tea , is a dual phosphoinositide-3-kinase / mTOR inhibitor .
19269153	0	Epigallocatechin_gallate	0,24	miR-16	42,48	Epigallocatechin gallate	miR-16	MESH:C045651	51573	Chemical	Gene	up-regulation|amod|START_ENTITY up-regulation|nmod|END_ENTITY	Epigallocatechin_gallate up-regulation of miR-16 and induction of apoptosis in human cancer cells .
18948169	0	Epigalocatechin-3-gallate	0,25	PEA15	47,52	Epigalocatechin-3-gallate	PEA15	null	8682	Chemical	Gene	downregulates|amod|START_ENTITY END_ENTITY|nsubj|downregulates	Epigalocatechin-3-gallate -LRB- EGCG -RRB- downregulates PEA15 and thereby augments TRAIL-mediated apoptosis in malignant_glioma .
16568663	0	Epimedii_Flavone	17,33	OPG	51,54	Epimedii Flavone	OPG	MESH:C046314	25341(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of Herba Epimedii_Flavone on expression of OPG and RANKL in rat osteoblasts -RSB- .
19408755	0	Epimedium	28,37	OPG	60,63	Epimedium	OPG	null	25341(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of total flavone of Epimedium on expression of bone OPG , OPGL mRNA in ovariectomized rats -RSB- .
9435641	0	Epinephrine	0,11	IL-1_beta	39,48	Epinephrine	IL-1 beta	MESH:D004837	3553	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	Epinephrine inhibits endotoxin-induced IL-1_beta production : roles of tumor_necrosis_factor-alpha and IL-10 .
21818153	0	Epinephrine	0,11	PDK4	20,24	Epinephrine	PDK4	MESH:D004837	89813(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Epinephrine induces PDK4 mRNA expression in adipose tissue from obese , insulin resistant rats .
25171187	0	Epinephrine	0,11	Renalase	19,27	Epinephrine	Renalase	MESH:D004837	55328	Chemical	Gene	Secretion|compound|START_ENTITY Secretion|compound|END_ENTITY	Epinephrine Evokes Renalase Secretion via a-Adrenoceptor/NF-kB Pathways in Renal Proximal Tubular Epithelial Cells .
26161982	0	Epinephrine	0,11	b2-Adrenoceptor	30,45	Epinephrine	b2-Adrenoceptor	MESH:D004837	154	Chemical	Gene	Activation|compound|START_ENTITY Activation|nmod|END_ENTITY	Epinephrine Activation of the b2-Adrenoceptor Is Required for IL-13-Induced Mucin Production in Human Bronchial Epithelial Cells .
2527244	0	Epinephrine	0,11	beta-endorphin	73,87	Epinephrine	beta-endorphin	MESH:D004837	5443	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	Epinephrine suppresses stress-induced increases in plasma immunoreactive beta-endorphin in humans .
17855349	0	Epinephrine	0,11	endothelial_nitric-oxide_synthase	30,63	Epinephrine	endothelial nitric-oxide synthase	MESH:D004837	287024(Tax:9913)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Epinephrine regulation of the endothelial_nitric-oxide_synthase : roles of RAC1 and beta3-adrenergic receptors in endothelial NO signaling .
2535942	0	Epinephrine	0,11	fibrinogen	29,39	Epinephrine	fibrinogen	MESH:D004837	2244	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Epinephrine induces platelet fibrinogen receptor expression , fibrinogen binding , and aggregation in whole blood in the absence of other excitatory agonists .
7904912	0	Epinephrine	0,11	gastrin	23,30	Epinephrine	gastrin	MESH:D004837	445524(Tax:9823)	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|END_ENTITY	Epinephrine effects on gastrin and gastric secretions in normal and stress-susceptible pigs and in dogs .
2569829	0	Epinephrine	0,11	insulin	75,82	Epinephrine	insulin	MESH:D004837	3630	Chemical	Gene	effect|nmod:poss|START_ENTITY independent|nsubj|effect independent|nmod|changes changes|nmod|END_ENTITY	Epinephrine 's effect on metabolic rate is independent of changes in plasma insulin or glucagon .
4938132	0	Epinephrine	0,11	insulin	47,54	Epinephrine	insulin	MESH:D004837	3630	Chemical	Gene	START_ENTITY|dep|inhibition inhibition|nmod|response response|compound|END_ENTITY	Epinephrine : selective inhibition of the acute insulin response to glucose .
6348987	0	Epinephrine	0,11	insulin	45,52	Epinephrine	insulin	MESH:D004837	3630	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|dobj|resistance resistance|compound|END_ENTITY	Epinephrine acutely mediates skeletal muscle insulin resistance .
1738372	0	Epinephrine	0,11	lipoprotein_lipase	21,39	Epinephrine	lipoprotein lipase	MESH:D004837	24539(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Epinephrine inhibits lipoprotein_lipase gene expression in rat adipocytes through multiple steps in posttranscriptional processing .
17698731	0	Epinephrine	0,11	phenylethanolamine_N-methyltransferase	77,115	Epinephrine	phenylethanolamine N-methyltransferase	MESH:D004837	18948(Tax:10090)	Chemical	Gene	required|nsubjpass|START_ENTITY required|xcomp|stress stress|nmod|mouse mouse|amod|END_ENTITY	Epinephrine is required for normal cardiovascular responses to stress in the phenylethanolamine_N-methyltransferase knockout mouse .
11163531	0	Epinephrine	0,11	superoxide_dismutase	24,44	Epinephrine	superoxide dismutase	MESH:D004837	6647	Chemical	Gene	upregulates|amod|START_ENTITY END_ENTITY|nsubj|upregulates	Epinephrine upregulates superoxide_dismutase in human coronary artery endothelial cells .
23679263	0	Epirubicin	0,10	CD25	28,32	Epirubicin	CD25	MESH:D015251	3559	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|compound|END_ENTITY	Epirubicin inhibits soluble CD25 secretion by Treg cells isolated from diffuse_large_B-cell_lymphoma patients .
22131069	0	Epirubicin	0,10	TRAIL	76,81	Epirubicin	TRAIL	MESH:D015251	8743	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|expression expression|compound|END_ENTITY	Epirubicin potentiates recombinant adeno-associated_virus_type_2 / 5-mediated TRAIL expression in fibroblast-like synoviocytes and augments the antiarthritic effects of rAAV2/5-TRAIL .
24682467	0	Epirubicin	0,10	UDP_glucuronosyltransferase_2B7	23,54	Epirubicin	UDP glucuronosyltransferase 2B7	MESH:D015251	7364	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Epirubicin upregulates UDP_glucuronosyltransferase_2B7 expression in liver_cancer cells via the p53 pathway .
21292834	0	Eplerenone	0,10	NOX-4	62,67	Eplerenone	NOX-4	MESH:C414690	85431(Tax:10116)	Chemical	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	Eplerenone suppresses aldosterone / salt-induced expression of NOX-4 .
20571278	0	Eplerenone	0,10	Vascular_Endothelial_Growth_Factor	35,69	Eplerenone	Vascular Endothelial Growth Factor	MESH:C414690	83785(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|Expression Expression|compound|END_ENTITY	Eplerenone Suppresses Salt-Induced Vascular_Endothelial_Growth_Factor Expression in the Kidney .
15590870	0	Eplerenone	0,10	aldosterone_receptor	24,44	Eplerenone	aldosterone receptor	MESH:C414690	4306	Chemical	Gene	START_ENTITY|dep|antagonist antagonist|compound|END_ENTITY	Eplerenone : a selective aldosterone_receptor antagonist for patients with heart_failure .
18585409	0	Eplerenone	0,10	angiotensin_II	64,78	Eplerenone	angiotensin II	MESH:C414690	183	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|actions actions|nmod|END_ENTITY	Eplerenone inhibits the intracrine and extracellular actions of angiotensin_II on the inward calcium current in the failing heart .
8436556	0	Epocarbazolins_A_and_B	0,22	5-lipoxygenase	30,44	Epocarbazolins A and B	5-lipoxygenase	null	25290(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitors inhibitors|amod|END_ENTITY	Epocarbazolins_A_and_B , novel 5-lipoxygenase inhibitors .
10942406	0	Epolones	0,8	erythropoietin	16,30	Epolones	erythropoietin	null	2056	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|compound|END_ENTITY	Epolones induce erythropoietin expression via hypoxia-inducible_factor-1_alpha activation .
9589059	0	Epostatin	0,9	dipeptidyl_peptidase_II	28,51	Epostatin	dipeptidyl peptidase II	MESH:C112180	29952	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Epostatin , new inhibitor of dipeptidyl_peptidase_II , produced by Streptomyces sp .
20674962	0	Epothilone_B	0,12	EpCAM	30,35	Epothilone B	EpCAM	MESH:C093788	4072	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	Epothilone_B enhances surface EpCAM expression in ovarian_cancer Hey cells .
15047209	0	Epothilone_B	53,65	Tumor_necrosis_factor-alpha	0,27	Epothilone B	Tumor necrosis factor-alpha	MESH:C093788	21926(Tax:10090)	Chemical	Gene	related|nmod|START_ENTITY related|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha related gene response to Epothilone_B in ovarian_cancer .
11062148	0	Epoxide	0,7	CYP2E1	58,64	Epoxide	CYP2E1	CHEBI:32955	13106(Tax:10090)	Chemical	Gene	formation|amod|START_ENTITY associated|nsubjpass|formation associated|nmod|inactivation inactivation|compound|END_ENTITY	Epoxide formation from diallyl_sulfone is associated with CYP2E1 inactivation in murine and human lungs .
18603781	0	Epoxyquinol_B	0,13	NF-kappaB	65,74	Epoxyquinol B	NF-kappaB	MESH:C469247	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Epoxyquinol_B , a naturally occurring pentaketide dimer , inhibits NF-kappaB signaling by crosslinking TAK1 .
12108551	0	Epoxysuccinyl	0,13	cathepsin_B	30,41	Epoxysuccinyl	cathepsin B	null	1508	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Epoxysuccinyl peptide-derived cathepsin_B inhibitors : modulating membrane permeability by conjugation with the C-terminal heptapeptide segment of penetratin .
11479257	0	Eptifibatide	0,12	thrombospondin	117,131	Eptifibatide	thrombospondin	MESH:C086648	7057	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|nmod|END_ENTITY	Eptifibatide and 7E3 , but not tirofiban , inhibit alpha -LRB- v -RRB- beta -LRB- 3 -RRB- integrin-mediated binding of smooth muscle cells to thrombospondin and prothrombin .
23725111	0	Equol	0,5	adiponectin	7,18	Equol	adiponectin	MESH:D060754	9370	Chemical	Gene	START_ENTITY|appos|levels levels|compound|END_ENTITY	Equol , adiponectin , insulin levels and risk of breast_cancer .
1439474	1	Ergometrine	69,80	oxytocin	114,122	Ergometrine	oxytocin	MESH:D004874	5020	Chemical	Gene	combined|nsubj|START_ENTITY combined|nmod|-RSB- -RSB-|compound|END_ENTITY	Ergometrine versus ergometrine combined with oxytocin -RSB- .
12646250	0	Ergothioneine	0,13	NF-kappa_B	63,73	Ergothioneine	NF-kappa B	MESH:D004880	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|compound|END_ENTITY	Ergothioneine inhibits oxidative stress - and TNF-alpha-induced NF-kappa_B activation and interleukin-8 release in alveolar epithelial cells .
26010889	0	Eriocalyxin_B	0,13	STAT3	116,121	Eriocalyxin B	STAT3	MESH:C516552	6774	Chemical	Gene	Signaling|compound|START_ENTITY Signaling|nmod|END_ENTITY	Eriocalyxin_B Inhibits STAT3 Signaling by Covalently Targeting STAT3 and Blocking Phosphorylation and Activation of STAT3 .
26010889	0	Eriocalyxin_B	0,13	STAT3	116,121	Eriocalyxin B	STAT3	MESH:C516552	6774	Chemical	Gene	Signaling|compound|START_ENTITY Signaling|nmod|END_ENTITY	Eriocalyxin_B Inhibits STAT3 Signaling by Covalently Targeting STAT3 and Blocking Phosphorylation and Activation of STAT3 .
26010889	0	Eriocalyxin_B	0,13	STAT3	23,28	Eriocalyxin B	STAT3	MESH:C516552	6774	Chemical	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	Eriocalyxin_B Inhibits STAT3 Signaling by Covalently Targeting STAT3 and Blocking Phosphorylation and Activation of STAT3 .
26010889	0	Eriocalyxin_B	0,13	STAT3	23,28	Eriocalyxin B	STAT3	MESH:C516552	6774	Chemical	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	Eriocalyxin_B Inhibits STAT3 Signaling by Covalently Targeting STAT3 and Blocking Phosphorylation and Activation of STAT3 .
26010889	0	Eriocalyxin_B	0,13	STAT3	63,68	Eriocalyxin B	STAT3	MESH:C516552	6774	Chemical	Gene	Signaling|compound|START_ENTITY Signaling|nmod|END_ENTITY	Eriocalyxin_B Inhibits STAT3 Signaling by Covalently Targeting STAT3 and Blocking Phosphorylation and Activation of STAT3 .
26010889	0	Eriocalyxin_B	0,13	STAT3	63,68	Eriocalyxin B	STAT3	MESH:C516552	6774	Chemical	Gene	Signaling|compound|START_ENTITY Signaling|nmod|END_ENTITY	Eriocalyxin_B Inhibits STAT3 Signaling by Covalently Targeting STAT3 and Blocking Phosphorylation and Activation of STAT3 .
22465804	0	Eriodictyol-7-O-glucoside	0,25	Nrf2	35,39	Eriodictyol-7-O-glucoside	Nrf2	null	4780	Chemical	Gene	START_ENTITY|appos|activator activator|amod|END_ENTITY	Eriodictyol-7-O-glucoside , a novel Nrf2 activator , confers protection against cisplatin-induced toxicity .
24466583	0	Eriodictyol-7-O-glucoside	0,25	Nrf2	36,40	Eriodictyol-7-O-glucoside	Nrf2	null	83619(Tax:10116)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Eriodictyol-7-O-glucoside activates Nrf2 and protects against cerebral_ischemic_injury .
23056346	0	Erioflorin	0,10	Pdcd4	43,48	Erioflorin	Pdcd4	null	18569(Tax:10090)	Chemical	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	Erioflorin stabilizes the tumor suppressor Pdcd4 by inhibiting its interaction with the E3-ligase b-TrCP1 .
26938194	0	Eritadenine	0,11	Angiotensin_Converting_Enzyme	55,84	Eritadenine	Angiotensin Converting Enzyme	MESH:C100029	1636	Chemical	Gene	START_ENTITY|nmod|Activity Activity|nmod|END_ENTITY	Eritadenine from Edible Mushrooms Inhibits Activity of Angiotensin_Converting_Enzyme in Vitro .
18006847	0	Erlotinib	0,9	ATP-binding_cassette_subfamily_B_member_1	41,82	Erlotinib	ATP-binding cassette subfamily B member 1	MESH:C400278	5243	Chemical	Gene	antagonizes|nsubj|START_ENTITY antagonizes|dobj|END_ENTITY	Erlotinib -LRB- Tarceva , OSI-774 -RRB- antagonizes ATP-binding_cassette_subfamily_B_member_1 and ATP-binding cassette subfamily G member 2-mediated drug resistance .
18524889	0	Erlotinib	0,9	BAX	223,226	Erlotinib	BAX	MESH:C400278	581	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Erlotinib induces mitochondrial-mediated apoptosis in human H3255 non-small-cell_lung_cancer cells with epidermal growth factor receptorL858R mutation through mitochondrial oxidative phosphorylation-dependent activation of BAX and BAK .
25479544	0	Erlotinib	67,76	BCRP	27,31	Erlotinib	BCRP	MESH:C400278	9429	Chemical	Gene	Role|nmod|START_ENTITY Expression|dep|Role Expression|compound|END_ENTITY	The EGFR Pathway Regulates BCRP Expression in NSCLC Cells : Role of Erlotinib .
21273611	0	Erlotinib	78,87	C-erbB-3	0,8	Erlotinib	C-erbB-3	MESH:C400278	2065	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|expression expression|amod|END_ENTITY	C-erbB-3 expression in non-small_cell_lung_cancer -LRB- NSCLC -RRB- patients treated by Erlotinib .
19267104	0	Erlotinib	0,9	EGFR	82,86	Erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	START_ENTITY|nmod|thymic_carcinoma thymic_carcinoma|nmod|overexpression overexpression|nmod|END_ENTITY	Erlotinib in advanced well-differentiated thymic_carcinoma with overexpression of EGFR : a case report .
20512075	0	Erlotinib	0,9	EGFR	72,76	Erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	mg|nsubj|START_ENTITY mg|nmod|non-small_cell_lung_cancers non-small_cell_lung_cancers|nmod|mutations mutations|amod|END_ENTITY	Erlotinib at a dose of 25 mg daily for non-small_cell_lung_cancers with EGFR mutations .
20723376	0	Erlotinib	34,43	EGFR	94,98	Erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	Monotherapy|compound|START_ENTITY Monotherapy|nmod|Epidermal_Growth_Factor_Receptor Epidermal_Growth_Factor_Receptor|appos|END_ENTITY	-LSB- Pooled Analysis of the Trials of Erlotinib Monotherapy for Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- - mutant Advanced Non-small_Cell_Lung_Cancer . -RSB- .
21783417	0	Erlotinib	0,9	EGFR	81,85	Erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	START_ENTITY|nmod|non-small-cell_lung_cancer non-small-cell_lung_cancer|amod|chemotherapy chemotherapy|nmod|treatment treatment|nmod|patients patients|nmod|END_ENTITY	Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell_lung_cancer -LRB- OPTIMAL , CTONG-0802 -RRB- : a multicentre , open-label , randomised , phase 3 study .
22285168	0	Erlotinib	0,9	EGFR	99,103	Erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	START_ENTITY|nmod|chemotherapy chemotherapy|nmod|treatment treatment|nmod|patients patients|nmod|non-small-cell_lung_cancer non-small-cell_lung_cancer|amod|END_ENTITY	Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell_lung_cancer -LRB- EURTAC -RRB- : a multicentre , open-label , randomised phase 3 trial .
22399641	0	Erlotinib	0,9	EGFR	103,107	Erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|lung_adenocarcinoma lung_adenocarcinoma|nmod|alterations alterations|amod|END_ENTITY	Erlotinib treatment in patients with advanced lung_adenocarcinoma with CISH-positive and CISH-negative EGFR gene alterations .
23101586	0	Erlotinib	0,9	EGFR	62,66	Erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	binds|nsubj|START_ENTITY binds|dobj|conformations conformations|nmod|domain domain|amod|END_ENTITY	Erlotinib binds both inactive and active conformations of the EGFR tyrosine kinase domain .
23466741	0	Erlotinib	104,113	EGFR	13,17	Erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	Therapy|compound|START_ENTITY Detection|nmod|Therapy Detection|nmod|Mutation Mutation|compound|END_ENTITY	Detection of EGFR T790M Mutation in Pericardial Effusion from a Non-Small_Cell_Lung_Cancer Patient with Erlotinib Therapy .
23626560	0	Erlotinib	25,34	EGFR	39,43	Erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	START_ENTITY|nmod|Non-Small_Cell_Lung_Cancer Non-Small_Cell_Lung_Cancer|compound|END_ENTITY	Long-Term Treatment with Erlotinib for EGFR Wild-Type Non-Small_Cell_Lung_Cancer : A Case Report .
23945392	0	Erlotinib	0,9	EGFR	85,89	Erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	START_ENTITY|nmod|mutation mutation|nmod|END_ENTITY	Erlotinib response in an NSCLC patient with a novel compound G719D + L861R mutation in EGFR .
24772316	0	Erlotinib	0,9	EGFR	54,58	Erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	START_ENTITY|nmod|pemetrexed/cisplatin pemetrexed/cisplatin|nmod|patients patients|nmod|lung_adenocarcinoma lung_adenocarcinoma|amod|END_ENTITY	Erlotinib with pemetrexed/cisplatin for patients with EGFR wild-type lung_adenocarcinoma with brain_metastases .
25175099	0	Erlotinib	0,9	EGFR	135,139	Erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	mutations|amod|START_ENTITY mutations|compound|END_ENTITY	Erlotinib alone or with bevacizumab as first-line therapy in patients with advanced non-squamous non-small-cell_lung_cancer harbouring EGFR mutations -LRB- JO25567 -RRB- : an open-label , randomised , multicentre , phase 2 study .
25479544	0	Erlotinib	67,76	EGFR	4,8	Erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	Role|nmod|START_ENTITY Expression|dep|Role Expression|compound|END_ENTITY	The EGFR Pathway Regulates BCRP Expression in NSCLC Cells : Role of Erlotinib .
25522765	0	Erlotinib	27,36	EGFR	99,103	Erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	Growth|compound|START_ENTITY Onartuzumab|nmod|Growth Onartuzumab|nmod|Mutations Mutations|compound|END_ENTITY	Combining Onartuzumab with Erlotinib Inhibits Growth of Non-Small_Cell_Lung_Cancer with Activating EGFR Mutations and HGF Overexpression .
25561229	0	Erlotinib	61,70	EGFR	26,30	Erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	Responsive|nmod|START_ENTITY Responsive|compound|END_ENTITY	Gene Mutation Analysis in EGFR Wild Type NSCLC Responsive to Erlotinib : Are There Features to Guide Patient Selection ?
25829397	0	Erlotinib	166,175	EGFR	33,37	Erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	Treated|nmod|START_ENTITY Outcomes|nmod|Treated Changes|nmod|Outcomes Changes|nmod|Mutations Mutations|compound|END_ENTITY	Detection and Dynamic Changes of EGFR Mutations from Circulating Tumor DNA as a Predictor of Survival Outcomes in NSCLC Patients Treated with First-line Intercalated Erlotinib and Chemotherapy .
25967687	0	Erlotinib	0,9	EGFR	14,18	Erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Erlotinib : An EGFR inhibitor with therapeutic benefit in non-small_cell_lung_cancer .
26004768	0	Erlotinib	96,105	EGFR	34,38	Erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	Observation|compound|START_ENTITY Biomarkers|nmod|Observation Biomarkers|appos|END_ENTITY	Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- Pathway Biomarkers in the Randomized Phase III Trial of Erlotinib Versus Observation in Ovarian_Cancer Patients with No Evidence of Disease Progression after First-Line Platinum-Based Chemotherapy .
26053020	0	Erlotinib	68,77	EGFR	124,128	Erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	START_ENTITY|nmod|Lung_Cancer Lung_Cancer|appos|END_ENTITY	Exogenous Restoration of TUSC2 Expression Induces Responsiveness to Erlotinib in Wildtype Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- Lung_Cancer Cells through Context Specific Pathways Resulting in Enhanced Therapeutic Efficacy .
26081300	0	Erlotinib	79,88	EGFR	98,102	Erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	Cost-Effectiveness|nmod|START_ENTITY Based|nsubj|Cost-Effectiveness Based|nmod|Testing Testing|compound|END_ENTITY	Cost-Effectiveness of an Individualized First-Line Treatment Strategy Offering Erlotinib Based on EGFR Mutation Testing in Advanced Lung_Adenocarcinoma Patients in Germany .
26195767	0	Erlotinib	0,9	EGFR	71,75	Erlotinib	EGFR	MESH:C400278	13649(Tax:10090)	Chemical	Gene	protects|nsubj|START_ENTITY protects|advcl|needs needs|dobj|END_ENTITY	Erlotinib protects against LPS-induced Endotoxicity because TLR4 needs EGFR to signal .
26195767	0	Erlotinib	0,9	EGFR	71,75	Erlotinib	EGFR	MESH:C400278	13649(Tax:10090)	Chemical	Gene	protects|nsubj|START_ENTITY protects|advcl|needs needs|dobj|END_ENTITY	Erlotinib protects against LPS-induced Endotoxicity because TLR4 needs EGFR to signal .
26207207	0	Erlotinib	0,9	EGFR	134,138	Erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	mutations|amod|START_ENTITY mutations|compound|END_ENTITY	Erlotinib alone or with bevacizumab as first-line therapy in patients with advanced non-squamous non-small-cell_lung_cancer harboring EGFR mutations -LRB- JO25567 -RRB- : an open-label , randomized , multicenter , phase II study .
26341921	0	Erlotinib	67,76	EGFR	119,123	Erlotinib	EGFR	MESH:C400278	13649(Tax:10090)	Chemical	Gene	Resistance|acl|START_ENTITY Resistance|nmod|Lung_Adenocarcinoma Lung_Adenocarcinoma|compound|END_ENTITY	Afatinib plus Cetuximab Delays Resistance Compared to Single-Agent Erlotinib or Afatinib in Mouse Models of TKI-Na ve EGFR L858R-Induced Lung_Adenocarcinoma .
26380188	0	Erlotinib	0,9	EGFR	74,78	Erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	therapy|amod|START_ENTITY therapy|nmod|therapy therapy|nmod|patients patients|nmod|non-small_cell_lung_cancer non-small_cell_lung_cancer|amod|END_ENTITY	Erlotinib therapy after initial platinum doublet therapy in patients with EGFR wild type non-small_cell_lung_cancer : results of a combined patient-level analysis of the NCIC CTG BR .21 and SATURN trials .
26409604	0	Erlotinib	47,56	EGFR	130,134	Erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	Cost-Effectiveness|nmod|START_ENTITY Cost-Effectiveness|nmod|Treatment Treatment|nmod|Cancer Cancer|compound|END_ENTITY	Cost-Effectiveness and Value of Information of Erlotinib , Afatinib , and Cisplatin-Pemetrexed for First-Line Treatment of Advanced EGFR Mutation-Positive Non-Small-Cell Lung Cancer in the United States .
26536620	0	Erlotinib	48,57	EGFR	80,84	Erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	Strategies|compound|START_ENTITY Strategies|nmod|Patients Patients|compound|END_ENTITY	Dose-Dependent Mutation Rates Determine Optimum Erlotinib Dosing Strategies for EGFR Mutant Non-Small_Cell_Lung_Cancer Patients .
26722080	0	Erlotinib	18,27	EGFR	128,132	Erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	START_ENTITY|nmod|Gene Gene|compound|END_ENTITY	Pemetrexed Versus Erlotinib in the Second-line Treatment of Patients with Advanced-stage Non-squamous NSCLC Harboring Wild-type EGFR Gene .
26773740	0	Erlotinib	34,43	EGFR	126,130	Erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	Outcomes|nmod|START_ENTITY Examining|dobj|Outcomes Examining|nmod|Patients Patients|nmod|Mutations Mutations|compound|END_ENTITY	Examining Treatment Outcomes with Erlotinib in Patients with Advanced Non-Small_Cell_Lung_Cancer_Whose_Tumors Harbor Uncommon EGFR Mutations .
26805738	0	Erlotinib	13,22	EGFR	56,60	Erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	START_ENTITY|nmod|Mutation Mutation|compound|END_ENTITY	-LSB- Response of Erlotinib in Lung_Adenocarcinoma Harboring EGFR Sensitive Mutation in Cerebrospinal Fluid : Case Report -RSB- .
26944770	0	Erlotinib	78,87	EGFR	166,170	Erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	Impact|nmod|START_ENTITY Impact|nmod|Patients Patients|nmod|Mutations Mutations|compound|END_ENTITY	Clinical Impact of Gastric Acid-Suppressing Medication Use on the Efficacy of Erlotinib and Gefitinib in Patients With Advanced Non-Small-Cell Lung Cancer Harboring EGFR Mutations .
26958085	0	Erlotinib	68,77	EGFR	36,40	Erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	Synergize|compound|START_ENTITY Inhibitor|appos|Synergize Inhibitor|compound|END_ENTITY	Ganoderma lucidum Combined with the EGFR Tyrosine Kinase Inhibitor , Erlotinib Synergize to Reduce Inflammatory Breast Cancer Progression .
27032107	0	Erlotinib	37,46	EGFR	117,121	Erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	START_ENTITY|nmod|Non-Small_Cell_Lung_Cancer Non-Small_Cell_Lung_Cancer|acl|Carrying Carrying|dobj|Mutation Mutation|compound|END_ENTITY	Prospective Evaluation of First-Line Erlotinib in Advanced Non-Small_Cell_Lung_Cancer -LRB- NSCLC -RRB- Carrying an Activating EGFR Mutation : A Multicenter Academic Phase II Study in Caucasian Patients -LRB- FIELT -RRB- .
27056749	0	Erlotinib	108,117	EGFR	46,50	Erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	Observation|compound|START_ENTITY Biomarkers|nmod|Observation Biomarkers|dep|END_ENTITY	Erratum to : Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- Pathway Biomarkers in the Randomized Phase III Trial of Erlotinib Versus Observation in Ovarian_Cancer Patients with No Evidence of Disease Progression after First-Line Platinum-Based Chemotherapy .
26961350	0	Erlotinib	27,36	EGF_Receptor	0,12	Erlotinib	EGF Receptor	MESH:C400278	13649(Tax:10090)	Chemical	Gene	Reabsorption|compound|START_ENTITY Inhibition|nmod|Reabsorption Inhibition|compound|END_ENTITY	EGF_Receptor Inhibition by Erlotinib Increases Aquaporin_2-Mediated Renal Water Reabsorption .
20477246	0	Erlotinib	0,9	EGF_receptor	14,26	Erlotinib	EGF receptor	MESH:C400278	1956	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Erlotinib : an EGF_receptor tyrosine kinase inhibitor in non-small-cell lung_cancer treatment .
20723376	0	Erlotinib	34,43	Epidermal_Growth_Factor_Receptor	60,92	Erlotinib	Epidermal Growth Factor Receptor	MESH:C400278	1956	Chemical	Gene	Monotherapy|compound|START_ENTITY Monotherapy|nmod|END_ENTITY	-LSB- Pooled Analysis of the Trials of Erlotinib Monotherapy for Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- - mutant Advanced Non-small_Cell_Lung_Cancer . -RSB- .
26004768	0	Erlotinib	96,105	Epidermal_Growth_Factor_Receptor	0,32	Erlotinib	Epidermal Growth Factor Receptor	MESH:C400278	1956	Chemical	Gene	Observation|compound|START_ENTITY Biomarkers|nmod|Observation END_ENTITY|dobj|Biomarkers	Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- Pathway Biomarkers in the Randomized Phase III Trial of Erlotinib Versus Observation in Ovarian_Cancer Patients with No Evidence of Disease Progression after First-Line Platinum-Based Chemotherapy .
26053020	0	Erlotinib	68,77	Epidermal_Growth_Factor_Receptor	90,122	Erlotinib	Epidermal Growth Factor Receptor	MESH:C400278	1956	Chemical	Gene	START_ENTITY|nmod|Lung_Cancer Lung_Cancer|compound|END_ENTITY	Exogenous Restoration of TUSC2 Expression Induces Responsiveness to Erlotinib in Wildtype Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- Lung_Cancer Cells through Context Specific Pathways Resulting in Enhanced Therapeutic Efficacy .
26336854	0	Erlotinib	112,121	Epidermal_Growth_Factor_Receptor	12,44	Erlotinib	Epidermal Growth Factor Receptor	MESH:C400278	1956	Chemical	Gene	Treated|nmod|START_ENTITY Treated|nsubj|Analysis Analysis|nmod|Mutations Mutations|compound|END_ENTITY	Analysis of Epidermal_Growth_Factor_Receptor Mutations in Serum Among Japanese Patients Treated With First-Line Erlotinib for Advanced Non-Small-Cell_Lung_Cancer .
27056749	0	Erlotinib	108,117	Epidermal_Growth_Factor_Receptor	12,44	Erlotinib	Epidermal Growth Factor Receptor	MESH:C400278	1956	Chemical	Gene	Observation|compound|START_ENTITY Biomarkers|nmod|Observation END_ENTITY|xcomp|Biomarkers	Erratum to : Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- Pathway Biomarkers in the Randomized Phase III Trial of Erlotinib Versus Observation in Ovarian_Cancer Patients with No Evidence of Disease Progression after First-Line Platinum-Based Chemotherapy .
26291013	0	Erlotinib	80,89	PTPRF	0,5	Erlotinib	PTPRF	MESH:C400278	5792	Chemical	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	PTPRF Expression as a Potential Prognostic/Predictive Marker for Treatment with Erlotinib in Non-Small-Cell Lung_Cancer .
26291013	0	Erlotinib	80,89	PTPRF	0,5	Erlotinib	PTPRF	MESH:C400278	5792	Chemical	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	PTPRF Expression as a Potential Prognostic/Predictive Marker for Treatment with Erlotinib in Non-Small-Cell Lung_Cancer .
12820772	0	Erlotinib	0,9	epidermal_growth_factor_receptor	48,80	Erlotinib	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	START_ENTITY|dep|drug drug|acl|targeting targeting|dobj|kinase kinase|compound|END_ENTITY	Erlotinib -LRB- Tarceva -RRB- : a promising drug targeting epidermal_growth_factor_receptor tyrosine kinase .
17283159	0	Erlotinib	0,9	epidermal_growth_factor_receptor	107,139	Erlotinib	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|cells cells|acl|lacking lacking|dobj|expression expression|compound|END_ENTITY	Erlotinib directly inhibits HER2 kinase activation and downstream signaling events in intact cells lacking epidermal_growth_factor_receptor expression .
17456787	0	Erlotinib	0,9	epidermal_growth_factor_receptor	24,56	Erlotinib	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Erlotinib , an effective epidermal_growth_factor_receptor tyrosine kinase inhibitor , induces p27KIP1 up-regulation and nuclear translocation in association with cell growth inhibition and G1/S phase arrest in human non-small-cell_lung_cancer cell lines .
21847041	0	Erlotinib	0,9	epidermal_growth_factor_receptor	163,195	Erlotinib	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	accumulation|amod|START_ENTITY accumulation|dep|visualization visualization|nmod|tomography tomography|nmod|patient patient|acl|harboring harboring|dobj|mutation mutation|nmod|END_ENTITY	Erlotinib accumulation in brain metastases from non-small_cell_lung_cancer : visualization by positron emission tomography in a patient harboring a mutation in the epidermal_growth_factor_receptor .
22170031	0	Erlotinib	0,9	epidermal_growth_factor_receptor	89,121	Erlotinib	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|nmod|expression expression|compound|END_ENTITY	Erlotinib prevents experimental metastases of human small cell lung_cancer cells with no epidermal_growth_factor_receptor expression .
23210009	0	Erlotinib	0,9	epidermal_growth_factor_receptor	43,75	Erlotinib	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	eradicates|nsubj|START_ENTITY eradicates|nmod|non-small_cell_lung_cancer non-small_cell_lung_cancer|amod|END_ENTITY	Erlotinib eradicates brain metastases from epidermal_growth_factor_receptor mutant non-small_cell_lung_cancer .
24250733	0	Erlotinib	0,9	epidermal_growth_factor_receptor	23,55	Erlotinib	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	START_ENTITY|nmod|non-small_cell_lung_cancer non-small_cell_lung_cancer|compound|END_ENTITY	Erlotinib in wild type epidermal_growth_factor_receptor non-small_cell_lung_cancer : A systematic review .
24868098	0	Erlotinib	52,61	epidermal_growth_factor_receptor	137,169	Erlotinib	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	START_ENTITY|nmod|treatment treatment|nmod|non-small_cell_lung_cancer non-small_cell_lung_cancer|nmod|exon exon|compound|END_ENTITY	U.S. Food and Drug Administration approval summary : Erlotinib for the first-line treatment of metastatic non-small_cell_lung_cancer with epidermal_growth_factor_receptor exon 19 deletions or exon 21 -LRB- L858R -RRB- substitution mutations .
26046796	0	Erlotinib	0,9	epidermal_growth_factor_receptor	49,81	Erlotinib	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	effective|nsubj|START_ENTITY effective|nmod|pancreatic_cancer pancreatic_cancer|nmod|mutations mutations|compound|END_ENTITY	Erlotinib is effective in pancreatic_cancer with epidermal_growth_factor_receptor mutations : a randomized , open-label , prospective trial .
17407812	0	Ertiprotafib	16,28	IkappaB_kinase_beta	59,78	Ertiprotafib	IkappaB kinase beta	MESH:C498182	3551	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	PTP1B inhibitor Ertiprotafib is also a potent inhibitor of IkappaB_kinase_beta -LRB- IKK-beta -RRB- .
9230759	0	Erythromycin	0,12	IL-8	23,27	Erythromycin	IL-8	MESH:D004917	3576	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|compound|END_ENTITY	Erythromycin modulates IL-8 expression in normal and inflamed human bronchial epithelial cells .
10543746	0	Erythromycin	0,12	NF-kappaB	52,61	Erythromycin	NF-kappaB	MESH:D004917	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	Erythromycin inhibits transcriptional activation of NF-kappaB , but not NFAT , through calcineurin-independent signaling in T cells .
14994385	0	Erythromycin	0,12	cyclooxygenase-2	42,58	Erythromycin	cyclooxygenase-2	MESH:D004917	5743	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|nmod|END_ENTITY	Erythromycin suppresses the expression of cyclooxygenase-2 in rheumatoid synovial cells .
10926336	0	Erythromycin	0,12	interleukin-8	63,76	Erythromycin	interleukin-8	MESH:D004917	3576	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|appos|release release|amod|END_ENTITY	Erythromycin inhibits beta2-integrins -LRB- CD11b/CD18 -RRB- expression , interleukin-8 release and intracellular oxidative metabolism in neutrophils .
7763252	0	Erythromycin	0,12	interleukin_6	24,37	Erythromycin	interleukin 6	MESH:D004917	3569	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Erythromycin suppresses interleukin_6 expression by human bronchial epithelial cells : a potential mechanism of its anti-inflammatory action .
2782416	0	Erythromycin	0,12	motilin	18,25	Erythromycin	motilin	MESH:D004917	4295	Chemical	Gene	agonist|nsubj|START_ENTITY agonist|amod|END_ENTITY	Erythromycin is a motilin receptor agonist .
6507625	0	Erythromycin	0,12	motilin	30,37	Erythromycin	motilin	MESH:D004917	481748(Tax:9615)	Chemical	Gene	mimics|nsubj|START_ENTITY mimics|dobj|END_ENTITY	Erythromycin mimics exogenous motilin in gastrointestinal contractile activity in the dog .
8470625	0	Erythromycin	0,12	motilin	16,23	Erythromycin	motilin	MESH:D004917	4295	Chemical	Gene	START_ENTITY|dep|agonist agonist|compound|END_ENTITY	Erythromycin : a motilin agonist and gastrointestinal prokinetic agent .
8780573	0	Erythromycin	0,12	motilin	68,75	Erythromycin	motilin	MESH:D004917	100009276(Tax:9986)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|rabbit rabbit|nmod|receptors receptors|compound|END_ENTITY	Erythromycin inhibits rabbit pyloric smooth muscle through neuronal motilin receptors .
9612923	0	Erythromycin	0,12	motilin	16,23	Erythromycin	motilin	MESH:D004917	4295	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Erythromycin , a motilin agonist , increases postprandial gallbladder emptying during therapy with ursodeoxycholic_acid .
1416647	0	Erythromycin	0,12	tumor_necrosis_factor_alpha	57,84	Erythromycin	tumor necrosis factor alpha	MESH:D004917	7124	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|production production|compound|END_ENTITY	Erythromycin inhibition of lipopolysaccharide-stimulated tumor_necrosis_factor_alpha production by human monocytes in vitro .
25675906	0	Escitalopram	87,99	TREK-1	50,56	Escitalopram	TREK-1	MESH:D015283	170899(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	The Role of the Two-Pore Domain Potassium Channel TREK-1 in the Therapeutic Effects of Escitalopram in a Rat Model of Poststroke_Depression .
24045971	0	Escitalopram	0,12	hERG	22,26	Escitalopram	hERG	MESH:D015283	2078	Chemical	Gene	block|amod|START_ENTITY block|nmod|channels channels|amod|END_ENTITY	Escitalopram block of hERG potassium channels .
18789789	0	Escitalopram	1,13	serotonin_transporter	69,90	Escitalopram	serotonin transporter	MESH:D015283	25553(Tax:10116)	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Escitalopram : a selective inhibitor and allosteric modulator of the serotonin_transporter -RSB- .
21901317	0	Escitalopram	0,12	serotonin_transporter	65,86	Escitalopram	serotonin transporter	MESH:D015283	6532	Chemical	Gene	START_ENTITY|appos|antidepressant antidepressant|nmod|effect effect|nmod|END_ENTITY	Escitalopram , an antidepressant with an allosteric effect at the serotonin_transporter -- a review of current understanding of its mechanism of action .
24991788	0	Esculentic_acid	0,15	COX-2	39,44	Esculentic acid	COX-2	null	17709(Tax:10090)	Chemical	Gene	inhibitor|advcl|START_ENTITY inhibitor|nsubj|END_ENTITY	Esculentic_acid , a novel and selective COX-2 inhibitor with anti-inflammatory effect in vivo and in vitro .
26983245	0	Esculentoside_A	11,26	AQP2	44,48	Esculentoside A	AQP2	MESH:C076297	25386(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|Expression Expression|nmod|END_ENTITY	-LSB- Effect of Esculentoside_A on Expression of AQP2 and AQP4 Protein of Kidney in Water-Loaded Rats -RSB- .
9566020	0	Esculentoside_A	0,15	tumor_necrosis_factor	25,46	Esculentoside A	tumor necrosis factor	MESH:C076297	21926(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Esculentoside_A inhibits tumor_necrosis_factor , interleukin-1 , and interleukin-6 production induced by lipopolysaccharide in mice .
22581442	0	Esculetin	0,9	type_I_procollagen	19,37	Esculetin	type I procollagen	MESH:C007628	1278	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|compound|END_ENTITY	Esculetin promotes type_I_procollagen expression in human dermal fibroblasts through MAPK and PI3K/Akt pathways .
7957532	0	Esmolol	0,7	beta_1-adrenoceptor	41,60	Esmolol	beta 1-adrenoceptor	MESH:C036604	153	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Esmolol , an ultrashort-acting , selective beta_1-adrenoceptor antagonist : pharmacodynamic and pharmacokinetic properties .
22253635	0	Esomeprazole	119,131	Substance_P	15,26	Esomeprazole	Substance P	MESH:D064098	6863	Chemical	Gene	Therapy|compound|START_ENTITY Effect|nmod|Therapy END_ENTITY|dep|Effect	Induced Sputum Substance_P in Children with Difficult-to-Treat Bronchial Asthma and Gastroesophageal Reflux : Effect of Esomeprazole Therapy .
12191493	0	Estradiol	0,9	Akt	19,22	Estradiol	Akt	MESH:D004958	24185(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activation activation|compound|END_ENTITY	Estradiol enhances Akt activation in cortical explant cultures following neuronal_injury .
12554767	0	Estradiol	0,9	Akt	28,31	Estradiol	Akt	MESH:D004958	207	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Estradiol rapidly activates Akt via the ErbB2 signaling pathway .
16087293	0	Estradiol	0,9	Akt	50,53	Estradiol	Akt	MESH:D004958	24185(Tax:10116)	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|dobj|phosphorylation phosphorylation|compound|decrease decrease|nmod|END_ENTITY	Estradiol prevents the injury-induced decrease of Akt activation and Bad phosphorylation .
19265681	0	Estradiol	0,9	Akt	21,24	Estradiol	Akt	MESH:D004958	24185(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Estradiol stimulates Akt , AMP-activated protein kinase -LRB- AMPK -RRB- and TBC1D1/4 , but not glucose uptake in rat soleus .
24832603	0	Estradiol	0,9	Akt	93,96	Estradiol	Akt	MESH:D004958	11651(Tax:10090)	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|addiction addiction|nmod|reactivation reactivation|nmod|END_ENTITY	Estradiol promotes pentose_phosphate pathway addiction and cell survival via reactivation of Akt in mTORC1 hyperactive cells .
11725052	0	Estradiol	11,20	Androgen_Receptor	86,103	Estradiol	Androgen Receptor	MESH:D004958	367	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|Synthesis Synthesis|nmod|END_ENTITY	Effects of Estradiol and Testosterone on the Synthesis , Expression and Degradation of Androgen_Receptor in Human Uterine Endometrial Fibroblasts .
19117054	0	Estradiol	0,9	BTG2	54,58	Estradiol	BTG2	MESH:D004958	7832	Chemical	Gene	downregulation|amod|START_ENTITY downregulation|nmod|END_ENTITY	Estradiol downregulation of the tumor suppressor gene BTG2 requires estrogen_receptor-alpha and the REA corepressor .
9559922	0	Estradiol	0,9	Bcl-2	22,27	Estradiol	Bcl-2	MESH:D004958	24224(Tax:10116)	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	Estradiol upregulates Bcl-2 expression in adult brain neurons .
24807244	0	Estradiol	0,9	CCL20	76,81	Estradiol	CCL20	MESH:D004958	20297(Tax:10090)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Estradiol regulation of constitutive and keratinocyte_growth_factor-induced CCL20 and CXCL1 secretion by mouse uterine epithelial cells .
15050739	0	Estradiol	0,9	CD36	25,29	Estradiol	CD36	MESH:D004958	948	Chemical	Gene	down-regulates|amod|START_ENTITY END_ENTITY|nsubj|down-regulates	Estradiol down-regulates CD36 expression in human breast_cancer cells .
12645950	0	Estradiol	0,9	CD4	44,47	Estradiol	CD4	MESH:D004958	12504(Tax:10090)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|responses responses|compound|END_ENTITY	Estradiol enhances primary antigen-specific CD4 T cell responses and Th1 development in vivo .
24280132	0	Estradiol	0,9	CIP2A	19,24	Estradiol	CIP2A	MESH:D004958	57650	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	Estradiol enhances CIP2A expression by the activation of p70 S6 kinase .
26919293	0	Estradiol	0,9	Connexin_43	42,53	Estradiol	Connexin 43	MESH:D004958	24392(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|Expression Expression|compound|END_ENTITY	Estradiol Receptors Regulate Differential Connexin_43 Expression in F98 and C6 Glioma Cell Lines .
8039302	0	Estradiol	0,9	E-cadherin	20,30	Estradiol	E-cadherin	MESH:D004958	12550(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|levels levels|amod|END_ENTITY	Estradiol regulates E-cadherin mRNA levels in the surface epithelium of the mouse ovary .
8841417	0	Estradiol	0,9	E-cadherin	18,28	Estradiol	E-cadherin	MESH:D004958	12550(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|degradation degradation|amod|END_ENTITY	Estradiol induces E-cadherin degradation in mouse uterine epithelium during the estrous cycle and early pregnancy .
20347979	0	Estradiol	0,9	ER-beta	112,119	Estradiol	ER-beta	MESH:D004958	25149(Tax:10116)	Chemical	Gene	antagonize|nsubj|START_ENTITY antagonize|nmod|expression expression|nmod|pathways pathways|amod|END_ENTITY	Estradiol and genistein antagonize the ovariectomy effects on skeletal muscle myosin heavy chain expression via ER-beta mediated pathways .
19395996	0	Estradiol	0,9	G-protein-coupled_receptor_30	84,113	Estradiol	G-protein-coupled receptor 30	MESH:D004958	2852	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|nmod|END_ENTITY	Estradiol attenuates EGF-induced rapid uPAR mobilization and cell migration via the G-protein-coupled_receptor_30 in ovarian_cancer cells .
12130584	0	Estradiol	0,9	GDNF	21,25	Estradiol	GDNF	MESH:D004958	2668	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Estradiol stimulates GDNF expression in developing hypothalamic neurons .
11413861	0	Estradiol	0,9	GFAP	30,34	Estradiol	GFAP	MESH:D004958	24387(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Estradiol inhibits astrocytic GFAP expression in an animal model of neuroinflammation .
14602794	0	Estradiol	0,9	GH	84,86	Estradiol	GH	MESH:D004958	2688	Chemical	Gene	supplementation|amod|START_ENTITY enhances|nsubj|supplementation enhances|dobj|drive drive|nmod|secretion secretion|appos|END_ENTITY	Estradiol supplementation enhances submaximal feed-forward drive of growth_hormone -LRB- GH -RRB- secretion by recombinant human GH-releasing hormone-1 ,44 - amide in a putatively somatostatin-withdrawn milieu .
14715838	0	Estradiol	0,9	GH	98,100	Estradiol	GH	MESH:D004958	2688	Chemical	Gene	supplementation|amod|START_ENTITY doubles|nsubj|supplementation doubles|dobj|release release|nmod|growth_hormone growth_hormone|appos|END_ENTITY	Estradiol supplementation in postmenopausal women doubles rebound-like release of growth_hormone -LRB- GH -RRB- triggered by sequential infusion and withdrawal of somatostatin : evidence that estrogen facilitates endogenous GH-releasing hormone drive .
15001627	0	Estradiol	0,9	GH	52,54	Estradiol	GH	MESH:D004958	2688	Chemical	Gene	modulates|amod|START_ENTITY growth_hormone|nsubj|modulates growth_hormone|dobj|waveform waveform|appos|END_ENTITY	Estradiol supplementation modulates growth_hormone -LRB- GH -RRB- secretory-burst waveform and recombinant human insulin-like growth factor-I-enforced suppression of endogenously driven GH release in postmenopausal women .
27082452	0	Estradiol	0,9	GH	62,64	Estradiol	GH	MESH:D004958	2688	Chemical	Gene	stimulate|nsubj|START_ENTITY stimulate|dobj|proliferation proliferation|nmod|line line|compound|END_ENTITY	Estradiol and corticosterone stimulate the proliferation of a GH cell line , MtT/S : Proliferation of growth_hormone cells .
24114435	0	Estradiol	0,9	GH-releasing_hormone	61,81	Estradiol	GH-releasing hormone	MESH:D004958	2691	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Estradiol regulates GH-releasing peptide 's interactions with GH-releasing_hormone and somatostatin in postmenopausal women .
24097558	0	Estradiol	0,9	G_protein-coupled_estrogen_receptor	81,116	Estradiol	G protein-coupled estrogen receptor	MESH:D004958	171104(Tax:10116)	Chemical	Gene	activates|nsubj|START_ENTITY activates|nmod|END_ENTITY	Estradiol activates epithelial sodium channels in rat alveolar cells through the G_protein-coupled_estrogen_receptor .
25928008	0	Estradiol	0,9	HOTAIR	18,24	Estradiol	HOTAIR	MESH:D004958	100124700	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|levels levels|amod|END_ENTITY	Estradiol induces HOTAIR levels via GPER-mediated miR-148a inhibition in breast_cancer .
10982795	0	Estradiol	0,9	IGF-1	20,25	Estradiol	IGF-1	MESH:D004958	24482(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|amod|END_ENTITY	Estradiol decreases IGF-1 and IGF-1_receptor expression in rat aortic smooth muscle cells .
19109168	0	Estradiol	0,9	IL-8	20,24	Estradiol	IL-8	MESH:D004958	3576	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|secretion secretion|compound|END_ENTITY	Estradiol increases IL-8 secretion of normal human breast tissue and breast_cancer in vivo .
11676497	0	Estradiol	0,9	IRS-1	20,25	Estradiol	IRS-1	MESH:D004958	16367(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Estradiol increases IRS-1 gene expression and insulin signaling in breast_cancer cells .
366445	0	Estradiol	0,9	LH-RH	49,54	Estradiol	LH-RH	MESH:D004958	25194(Tax:10116)	Chemical	Gene	potentiation|amod|START_ENTITY potentiation|nmod|END_ENTITY	Estradiol potentiation of hypothalamic uptake of LH-RH from the CSF .
26982332	0	Estradiol	0,9	Leptin	69,75	Estradiol	Leptin	MESH:D004958	3952	Chemical	Gene	Agonists|nsubj|START_ENTITY Agonists|dobj|Actions Actions|nmod|END_ENTITY	Estradiol and Estrogen_Receptor Agonists Oppose Oncogenic Actions of Leptin in HepG2 Cells .
11872210	0	Estradiol	0,9	MCP-1	25,30	Estradiol	MCP-1	MESH:D004958	6347	Chemical	Gene	START_ENTITY|dobj|expression expression|compound|END_ENTITY	Estradiol down-regulates MCP-1 expression in human coronary artery endothelial cells .
9763529	0	Estradiol	0,9	MCP-1	21,26	Estradiol	MCP-1	MESH:D004958	100009130(Tax:9986)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Estradiol suppresses MCP-1 expression In vivo : implications for atherosclerosis .
18728002	0	Estradiol	0,9	MICA	20,24	Estradiol	MICA	MESH:D004958	100507436	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Estradiol regulates MICA expression in human endometrial cells .
7758243	0	Estradiol	0,9	N-cadherin	20,30	Estradiol	N-cadherin	MESH:D004958	12558(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|levels levels|amod|END_ENTITY	Estradiol regulates N-cadherin mRNA levels in the mouse ovary .
20351193	0	Estradiol	0,9	NF-kappa_B	21,31	Estradiol	NF-kappa B	MESH:D004958	4790	Chemical	Gene	suppresses|amod|START_ENTITY END_ENTITY|nsubj|suppresses	Estradiol suppresses NF-kappa_B activation through coordinated regulation of let-7a and miR-125b in primary human macrophages .
18258403	0	Estradiol	0,9	NMU	21,24	Estradiol	NMU	MESH:D004958	63887(Tax:10116)	Chemical	Gene	suppresses|amod|START_ENTITY END_ENTITY|nsubj|suppresses	Estradiol suppresses NMU mRNA expression during sexual maturation in the female rat pituitary .
19813763	0	Estradiol	0,9	P-gp	50,54	Estradiol	P-gp	MESH:D004958	5243	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Estradiol and progesterone-mediated regulation of P-gp in P-gp overexpressing cells -LRB- NCI-ADR-RES -RRB- and placental cells -LRB- JAR -RRB- .
19813763	0	Estradiol	0,9	P-gp	58,62	Estradiol	P-gp	MESH:D004958	5243	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|cells cells|compound|END_ENTITY	Estradiol and progesterone-mediated regulation of P-gp in P-gp overexpressing cells -LRB- NCI-ADR-RES -RRB- and placental cells -LRB- JAR -RRB- .
22975709	0	Estradiol	0,9	PAT1	73,77	Estradiol	PAT1	MESH:D004958	206358	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	Estradiol inhibits the activity of proton-coupled amino_acid transporter PAT1 expressed in Xenopus oocytes .
19210392	0	Estradiol	32,41	Prolactin	166,175	Estradiol	Prolactin	MESH:D004958	24683(Tax:10116)	Chemical	Gene	Exposure|nmod|START_ENTITY Effects|nmod|Exposure Effects|dep|Comparison Comparison|nmod|Deficiency Deficiency|compound|END_ENTITY	Effects of Neonatal Exposure to Estradiol on Prolactin Secretion and Activity of the Tubero-lnfundibular Dopamine System in Young Adulthood : Comparison with Neonatal Prolactin Deficiency * .
19210392	0	Estradiol	32,41	Prolactin	45,54	Estradiol	Prolactin	MESH:D004958	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|Secretion Secretion|compound|END_ENTITY	Effects of Neonatal Exposure to Estradiol on Prolactin Secretion and Activity of the Tubero-lnfundibular Dopamine System in Young Adulthood : Comparison with Neonatal Prolactin Deficiency * .
21315800	0	Estradiol	0,9	TGF-b1	20,26	Estradiol	TGF-b1	MESH:D004958	7040	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|compound|END_ENTITY	Estradiol modulates TGF-b1 expression and its signaling pathway in thyroid stromal cells .
21252492	0	Estradiol	0,9	TNF-a	38,43	Estradiol	TNF-a	MESH:D004958	24835(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Estradiol increases the expression of TNF-a and TNF_receptor_1 in lactotropes .
25627546	0	Estradiol	0,9	VCAM-1	50,56	Estradiol	VCAM-1	MESH:D004958	7412	Chemical	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	Estradiol Inhibits Cytokine-Induced Expression of VCAM-1 and ICAM-1 in Cultured Human Endothelial Cells Via AMPK/PPARa Activation .
16568303	0	Estradiol	0,9	VEGF	20,24	Estradiol	VEGF	MESH:D004958	7422	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Estradiol increases VEGF in human breast studied by whole-tissue culture .
18499749	7	Estradiol	1232,1241	VEGF	1257,1261	Estradiol	VEGF	MESH:D004958	7422	Chemical	Gene	replacement|amod|START_ENTITY replacement|nmod|marmosets marmosets|amod|END_ENTITY	Estradiol replacement in VEGF Trap-treated marmosets resulted in only a small increase in endothelial cell proliferation that remained significantly below control values .
25608994	0	Estradiol	1,10	VEGF	64,68	Estradiol	VEGF	MESH:D004958	7422	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|MAPK MAPK|acl|signaling signaling|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Estradiol activates MAPK signaling pathway by estrogen induced VEGF and bFGF in endometrial_cancer cells . -RSB-
6163790	0	Estradiol	0,9	alpha-fetoprotein	73,90	Estradiol	alpha-fetoprotein	MESH:D004958	11576(Tax:10090)	Chemical	Gene	chromatography|amod|START_ENTITY chromatography|dep|application application|nmod|purification purification|nmod|END_ENTITY	Estradiol affinity chromatography : application to purification of murine alpha-fetoprotein .
16707209	0	Estradiol	0,9	androgen-binding_protein	18,42	Estradiol	androgen-binding protein	MESH:D004958	24775(Tax:10116)	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|expression expression|amod|END_ENTITY	Estradiol affects androgen-binding_protein expression and fertilizing ability of spermatozoa in adult male rats .
17589598	0	Estradiol	0,9	androgen_receptor	36,53	Estradiol	androgen receptor	MESH:D004958	11835(Tax:10090)	Chemical	Gene	stimulate|nsubj|START_ENTITY stimulate|dobj|expression expression|compound|END_ENTITY	Estradiol and Bisphenol_A stimulate androgen_receptor and estrogen receptor gene expression in fetal mouse prostate mesenchyme cells .
15637314	0	Estradiol	0,9	angiopoietin-1	20,34	Estradiol	angiopoietin-1	MESH:D004958	11600(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Estradiol regulates angiopoietin-1 mRNA expression through estrogen_receptor-alpha in a rodent experimental stroke model .
20484461	0	Estradiol	0,9	apolipoprotein_A-IV	52,71	Estradiol	apolipoprotein A-IV	MESH:D004958	337	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|effect effect|nmod|END_ENTITY	Estradiol increases the anorectic effect of central apolipoprotein_A-IV .
25051443	0	Estradiol	0,9	apolipoprotein_A-IV	21,40	Estradiol	apolipoprotein A-IV	MESH:D004958	25080(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Estradiol stimulates apolipoprotein_A-IV gene expression in the nucleus of the solitary tract through estrogen receptor-a .
23584859	0	Estradiol	0,9	arginine-vasopressin	36,56	Estradiol	arginine-vasopressin	MESH:D004958	551	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Estradiol and testosterone regulate arginine-vasopressin expression in SH-SY5Y human female neuroblastoma cells through estrogen_receptors-a_and _ - b .
20176079	0	Estradiol	0,9	aryl_hydrocarbon_receptor	20,45	Estradiol	aryl hydrocarbon receptor	MESH:D004958	25690(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Estradiol regulates aryl_hydrocarbon_receptor expression in the rat uterus .
24650733	0	Estradiol	0,9	brain-derived_neurotrophic_factor	38,71	Estradiol	brain-derived neurotrophic factor	MESH:D004958	24225(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Estradiol increases expression of the brain-derived_neurotrophic_factor after acute administration of ethanol in the neonatal rat cerebellum .
11506987	0	Estradiol	0,9	c-Fos	46,51	Estradiol	c-Fos	MESH:D004958	314322(Tax:10116)	Chemical	Gene	increases|amod|START_ENTITY feeding-induced|nsubj|increases feeding-induced|dobj|expression expression|amod|END_ENTITY	Estradiol treatment increases feeding-induced c-Fos expression in the brains of ovariectomized rats .
12429561	0	Estradiol	0,9	c-Fos	42,47	Estradiol	c-Fos	MESH:D004958	314322(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY increases|nsubj|treatment increases|dobj|expression expression|amod|END_ENTITY	Estradiol treatment increases CCK-induced c-Fos expression in the brains of ovariectomized rats .
14627632	0	Estradiol	0,9	c-Fos	35,40	Estradiol	c-Fos	MESH:D004958	314322(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Estradiol differentially regulates c-Fos after focal cerebral_ischemia .
18753261	0	Estradiol	0,9	c-Fos	57,62	Estradiol	c-Fos	MESH:D004958	314322(Tax:10116)	Chemical	Gene	replacement|amod|START_ENTITY enhances|nsubj|replacement enhances|dobj|END_ENTITY	Estradiol replacement enhances sleep_deprivation-induced c-Fos immunoreactivity in forebrain arousal regions of ovariectomized rats .
10919270	0	Estradiol	0,9	c-fos	25,30	Estradiol	c-fos	MESH:D004958	314322(Tax:10116)	Chemical	Gene	stimulation|amod|START_ENTITY stimulation|nmod|expressions expressions|amod|END_ENTITY	Estradiol stimulation of c-fos and c-jun expressions and activator_protein-1 deoxyribonucleic acid binding activity in rat white adipocyte .
18765271	0	Estradiol	0,9	c-fos	31,36	Estradiol	c-fos	MESH:D004958	314322(Tax:10116)	Chemical	Gene	replacement|amod|START_ENTITY modifies|nsubj|replacement modifies|dobj|expression expression|amod|END_ENTITY	Estradiol replacement modifies c-fos expression at the spinomedullary junction evoked by temporomandibular_joint stimulation in ovariectomized female rats .
8314777	0	Estradiol	0,9	c-fos	151,156	Estradiol	c-fos	MESH:D004958	2353	Chemical	Gene	increases|amod|START_ENTITY antagonize|nsubj|increases antagonize|advcl|affecting affecting|dobj|synthesis synthesis|amod|END_ENTITY	Estradiol increases and anti-estrogens antagonize the growth factor-induced activator_protein-1 activity in MCF7 breast_cancer cells without affecting c-fos and c-jun synthesis .
7734397	0	Estradiol	0,9	c-myc	21,26	Estradiol	c-myc	MESH:D004958	4609	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Estradiol stimulates c-myc proto-oncogene expression in normal human breast epithelial cells in culture .
23535532	0	Estradiol	0,9	calreticulin	35,47	Estradiol	calreticulin	MESH:D004958	811	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Estradiol differentially regulates calreticulin : a potential link with abnormal T cell function in systemic_lupus_erythematosus ?
2990988	0	Estradiol	0,9	choline_acetyltransferase	20,45	Estradiol	choline acetyltransferase	MESH:D004958	290567(Tax:10116)	Chemical	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	Estradiol increases choline_acetyltransferase activity in specific basal forebrain nuclei and projection areas of female rats .
17947358	0	Estradiol	0,9	corticotropin-releasing_hormone_gene	20,56	Estradiol	corticotropin-releasing hormone gene	MESH:D004958	1392	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Estradiol regulates corticotropin-releasing_hormone_gene -LRB- crh -RRB- expression in a rapid and phasic manner that parallels estrogen_receptor-alpha_and _ - beta recruitment to a 3 ' ,5 ' - cyclic_adenosine_5 ' - monophosphate regulatory region of the proximal crh promoter .
17947358	0	Estradiol	0,9	crh	58,61	Estradiol	crh	MESH:D004958	1392	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|appos|END_ENTITY	Estradiol regulates corticotropin-releasing_hormone_gene -LRB- crh -RRB- expression in a rapid and phasic manner that parallels estrogen_receptor-alpha_and _ - beta recruitment to a 3 ' ,5 ' - cyclic_adenosine_5 ' - monophosphate regulatory region of the proximal crh promoter .
22982060	0	Estradiol	0,9	dimethylarginine_dimethylaminohydrolase	60,99	Estradiol	dimethylarginine dimethylaminohydrolase	MESH:D004958	23576	Chemical	Gene	restores|nsubj|START_ENTITY restores|dobj|activity activity|amod|END_ENTITY	Estradiol , acting through estrogen_receptor_alpha , restores dimethylarginine_dimethylaminohydrolase activity and nitric_oxide production in oxLDL-treated human arterial endothelial cells .
10077589	0	Estradiol	0,9	endothelial_nitric_oxide_synthase	57,90	Estradiol	endothelial nitric oxide synthase	MESH:D004958	287024(Tax:9913)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|translocation translocation|nmod|END_ENTITY	Estradiol induces the calcium-dependent translocation of endothelial_nitric_oxide_synthase .
2129303	0	Estradiol	0,9	epidermal_growth_factor	36,59	Estradiol	epidermal growth factor	MESH:D004958	25313(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|the the|nmod|END_ENTITY	Estradiol stimulates the binding of epidermal_growth_factor in cultured rat granulosa cells .
22493503	0	Estradiol	0,9	epidermal_growth_factor	85,108	Estradiol	epidermal growth factor	MESH:D004958	13645(Tax:10090)	Chemical	Gene	protects|nsubj|START_ENTITY protects|advcl|photoaging photoaging|nmod|release release|nmod|END_ENTITY	Estradiol protects dermal hyaluronan/versican matrix during photoaging by release of epidermal_growth_factor from keratinocytes .
10611355	0	Estradiol	0,9	estrogen_receptor	75,92	Estradiol	estrogen receptor	MESH:D004958	2099	Chemical	Gene	repression|amod|START_ENTITY requires|nsubj|repression requires|xcomp|function-2 function-2|nsubj|activation activation|compound|END_ENTITY	Estradiol repression of tumor_necrosis_factor-alpha transcription requires estrogen_receptor activation function-2 and is enhanced by coactivators .
1712910	0	Estradiol	0,9	estrogen_receptor	142,159	Estradiol	estrogen receptor	MESH:D004958	2099	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|absence absence|nmod|site site|nmod|END_ENTITY	Estradiol inhibits transcription of the human glycoprotein hormone alpha-subunit gene despite the absence of a high affinity binding site for estrogen_receptor .
7476978	0	Estradiol	0,9	estrogen_receptor	77,94	Estradiol	estrogen receptor	MESH:D004958	2099	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Estradiol and phorbol_ester cause phosphorylation of serine 118 in the human estrogen_receptor .
8129752	0	Estradiol	0,9	estrogen_receptor	97,114	Estradiol	estrogen receptor	MESH:D004958	2099	Chemical	Gene	derivatives|amod|START_ENTITY antagonize|nsubj|derivatives antagonize|dobj|association association|nmod|END_ENTITY	Estradiol derivatives bearing the side-chain of tamoxifen antagonize the association between the estrogen_receptor and calmodulin .
9719445	0	Estradiol	0,9	estrogen_receptor	20,37	Estradiol	estrogen receptor	MESH:D004958	2099	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|stability stability|compound|END_ENTITY	Estradiol regulates estrogen_receptor mRNA stability .
11157695	0	Estradiol	0,9	estrogen_receptor-alpha	75,98	Estradiol	estrogen receptor-alpha	MESH:D004958	13982(Tax:10090)	Chemical	Gene	accelerates|nsubj|START_ENTITY accelerates|ccomp|carotid carotid|nmod|END_ENTITY	Estradiol accelerates reendothelialization in mouse carotid artery through estrogen_receptor-alpha but not estrogen_receptor-beta .
15637314	0	Estradiol	0,9	estrogen_receptor-alpha	59,82	Estradiol	estrogen receptor-alpha	MESH:D004958	13982(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Estradiol regulates angiopoietin-1 mRNA expression through estrogen_receptor-alpha in a rodent experimental stroke model .
17084457	0	Estradiol	0,9	estrogen_receptor-alpha	49,72	Estradiol	estrogen receptor-alpha	MESH:D004958	13982(Tax:10090)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|cells cells|nmod|END_ENTITY	Estradiol activates mast cells via a non-genomic estrogen_receptor-alpha and calcium influx .
17596438	0	Estradiol	0,9	estrogen_receptor-alpha	128,151	Estradiol	estrogen receptor-alpha	MESH:D004958	2099	Chemical	Gene	targets|nsubj|START_ENTITY targets|xcomp|induce induce|dobj|formation formation|dep|role role|nmod|END_ENTITY	Estradiol targets synaptic proteins to induce glutamatergic synapse formation in cultured hippocampal neurons : critical role of estrogen_receptor-alpha .
18258268	0	Estradiol	0,9	estrogen_receptor-alpha	44,67	Estradiol	estrogen receptor-alpha	MESH:D004958	13982(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|splicing splicing|nmod|mRNA mRNA|amod|END_ENTITY	Estradiol regulates alternative splicing of estrogen_receptor-alpha mRNA in differentiated NG108-15 neuronal cells .
19117054	0	Estradiol	0,9	estrogen_receptor-alpha	68,91	Estradiol	estrogen receptor-alpha	MESH:D004958	2099	Chemical	Gene	downregulation|amod|START_ENTITY requires|nsubj|downregulation requires|dobj|END_ENTITY	Estradiol downregulation of the tumor suppressor gene BTG2 requires estrogen_receptor-alpha and the REA corepressor .
21498588	0	Estradiol	0,9	estrogen_receptor-alpha	55,78	Estradiol	estrogen receptor-alpha	MESH:D004958	13982(Tax:10090)	Chemical	Gene	administration|amod|START_ENTITY controls|nsubj|administration controls|nmod|activation activation|amod|END_ENTITY	Estradiol administration controls eosinophilia through estrogen_receptor-alpha activation during acute peritoneal inflammation .
25394658	0	Estradiol	0,9	estrogen_receptor-alpha	91,114	Estradiol	estrogen receptor-alpha	MESH:D004958	13982(Tax:10090)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|advcl|reducing reducing|dobj|liver liver|amod|cysteine_sulfinic_acid_decarboxylase cysteine_sulfinic_acid_decarboxylase|nmod|END_ENTITY	Estradiol decreases taurine level by reducing cysteine_sulfinic_acid_decarboxylase via the estrogen_receptor-alpha in female mice liver .
9858497	0	Estradiol	0,9	estrogen_receptor-alpha	23,46	Estradiol	estrogen receptor-alpha	MESH:D004958	443228(Tax:9940)	Chemical	Gene	up-regulates|amod|START_ENTITY END_ENTITY|nsubj|up-regulates	Estradiol up-regulates estrogen_receptor-alpha messenger ribonucleic acid in sheep endometrium by increasing its stability .
24726465	0	Estradiol	0,9	estrogen_receptor_a	92,111	Estradiol	estrogen receptor a	MESH:D004958	13982(Tax:10090)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|advcl|activating activating|dobj|END_ENTITY	Estradiol enhances object recognition memory in Swiss female mice by activating hippocampal estrogen_receptor_a .
10803594	0	Estradiol	0,9	estrogen_receptor_alpha	65,88	Estradiol	estrogen receptor alpha	MESH:D004958	2099	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|activating activating|dobj|END_ENTITY	Estradiol induces differential neuronal phenotypes by activating estrogen_receptor_alpha or beta .
17481887	0	Estradiol	0,9	estrone_sulfatase	23,40	Estradiol	estrone sulfatase	MESH:D004958	412	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Estradiol inhibits the estrone_sulfatase activity in normal and cancerous human breast tissues .
10342850	0	Estradiol	0,9	galanin	18,25	Estradiol	galanin	MESH:D004958	14419(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Estradiol induces galanin gene expression in the pituitary of the mouse in an estrogen_receptor_alpha-dependent manner .
24473434	0	Estradiol	0,9	ghrelin	47,54	Estradiol	ghrelin	MESH:D004958	58991(Tax:10090)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	Estradiol modulates Kiss1 neuronal response to ghrelin .
11796520	0	Estradiol	0,9	glial_fibrillary_acidic_protein	56,87	Estradiol	glial fibrillary acidic protein	MESH:D004958	24387(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|advcl|repressing repressing|dobj|expression expression|compound|END_ENTITY	Estradiol -LRB- E2 -RRB- enhances neurite outgrowth by repressing glial_fibrillary_acidic_protein expression and reorganizing laminin .
3567632	0	Estradiol	0,9	glial_fibrillary_acidic_protein	37,68	Estradiol	glial fibrillary acidic protein	MESH:D004958	24387(Tax:10116)	Chemical	Gene	START_ENTITY|dep|redistribution redistribution|nmod|immunoreactivity immunoreactivity|compound|END_ENTITY	Estradiol -- induced redistribution of glial_fibrillary_acidic_protein immunoreactivity in the rat brain .
11358672	0	Estradiol	0,9	glucocorticoid_receptor	19,42	Estradiol	glucocorticoid receptor	MESH:D004958	2908	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Estradiol inhibits glucocorticoid_receptor expression and induces glucocorticoid resistance in MCF-7 human breast_cancer cells .
11159828	0	Estradiol	0,9	gonadotropin-releasing_hormone	20,50	Estradiol	gonadotropin-releasing hormone	MESH:D004958	2796	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Estradiol regulates gonadotropin-releasing_hormone -LRB- GnRH -RRB- and its receptor gene expression and antagonizes the growth inhibitory effects of GnRH in human ovarian surface epithelial and ovarian_cancer cells .
19176881	0	Estradiol	0,9	gonadotropin-releasing_hormone	51,81	Estradiol	gonadotropin-releasing hormone	MESH:D004958	14714(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|neurons neurons|amod|END_ENTITY	Estradiol suppresses glutamatergic transmission to gonadotropin-releasing_hormone neurons in a model of negative feedback in mice .
20580637	0	Estradiol	0,9	gonadotropin-releasing_hormone	81,111	Estradiol	gonadotropin-releasing hormone	MESH:D004958	14714(Tax:10090)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|currents currents|nmod|neurons neurons|amod|END_ENTITY	Estradiol attenuates multiple tetrodotoxin-sensitive sodium currents in isolated gonadotropin-releasing_hormone neurons .
2163319	0	Estradiol	0,9	gonadotropin-releasing_hormone	38,68	Estradiol	gonadotropin-releasing hormone	MESH:D004958	2796	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|effectiveness effectiveness|nmod|END_ENTITY	Estradiol alters the effectiveness of gonadotropin-releasing_hormone -LRB- GnRH -RRB- in ovine pituitary cultures : GnRH_receptors versus responsiveness to GnRH .
22209345	0	Estradiol	0,9	gonadotropin-releasing_hormone	91,121	Estradiol	gonadotropin-releasing hormone	MESH:D004958	14714(Tax:10090)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|nmod|neurons neurons|amod|END_ENTITY	Estradiol directly attenuates sodium currents and depolarizing afterpotentials in isolated gonadotropin-releasing_hormone neurons .
3316263	0	Estradiol	0,9	gonadotropin-releasing_hormone	67,97	Estradiol	gonadotropin-releasing hormone	MESH:D004958	2796	Chemical	Gene	sensitization|amod|START_ENTITY cultured|nsubj|sensitization cultured|nmod|END_ENTITY	Estradiol sensitization of cultured human fetal pituitary cells to gonadotropin-releasing_hormone .
7545440	0	Estradiol	0,9	gonadotropin-releasing_hormone	86,116	Estradiol	gonadotropin-releasing hormone	MESH:D004958	2796	Chemical	Gene	influence|nsubj|START_ENTITY influence|dobj|synthesis synthesis|nmod|gonadotropins gonadotropins|nmod|absence absence|nmod|END_ENTITY	Estradiol and progesterone influence the synthesis of gonadotropins in the absence of gonadotropin-releasing_hormone in the ewe .
8445015	0	Estradiol	0,9	gonadotropin-releasing_hormone	103,133	Estradiol	gonadotropin-releasing hormone	MESH:D004958	2796	Chemical	Gene	amplifies|nsubj|START_ENTITY amplifies|dobj|amount amount|nmod|hormone hormone|acl|secreted secreted|nmod|doses doses|nmod|END_ENTITY	Estradiol amplifies the amount of luteinizing hormone -LRB- LH -RRB- secreted in response to increasing doses of gonadotropin-releasing_hormone by specifically augmenting the duration of evoked LH secretory events and hence their mass .
9389526	0	Estradiol	0,9	gonadotropin-releasing_hormone	60,90	Estradiol	gonadotropin-releasing hormone	MESH:D004958	2796	Chemical	Gene	requirements|amod|START_ENTITY requirements|nmod|surge surge|amod|END_ENTITY	Estradiol requirements for induction and maintenance of the gonadotropin-releasing_hormone surge : implications for neuroendocrine processing of the estradiol signal .
1332908	0	Estradiol	0,9	gonadotropin-releasing_hormone_receptor	20,59	Estradiol	gonadotropin-releasing hormone receptor	MESH:D004958	2798	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|amod|END_ENTITY	Estradiol regulates gonadotropin-releasing_hormone_receptor number , growth and inositol_phosphate production in alpha T3-1 cells .
11967186	0	Estradiol	0,9	growth_hormone	24,38	Estradiol	growth hormone	MESH:D004958	2688	Chemical	Gene	modulation|amod|START_ENTITY modulation|nmod|secretion secretion|amod|END_ENTITY	Estradiol modulation of growth_hormone secretion in the ewe : no growth_hormone-releasing hormone neurons and few somatotropes express estradiol receptor alpha .
14602794	0	Estradiol	0,9	growth_hormone	68,82	Estradiol	growth hormone	MESH:D004958	2688	Chemical	Gene	supplementation|amod|START_ENTITY enhances|nsubj|supplementation enhances|dobj|drive drive|nmod|secretion secretion|amod|END_ENTITY	Estradiol supplementation enhances submaximal feed-forward drive of growth_hormone -LRB- GH -RRB- secretion by recombinant human GH-releasing hormone-1 ,44 - amide in a putatively somatostatin-withdrawn milieu .
14715838	0	Estradiol	0,9	growth_hormone	82,96	Estradiol	growth hormone	MESH:D004958	2688	Chemical	Gene	supplementation|amod|START_ENTITY doubles|nsubj|supplementation doubles|dobj|release release|nmod|END_ENTITY	Estradiol supplementation in postmenopausal women doubles rebound-like release of growth_hormone -LRB- GH -RRB- triggered by sequential infusion and withdrawal of somatostatin : evidence that estrogen facilitates endogenous GH-releasing hormone drive .
15001627	0	Estradiol	0,9	growth_hormone	36,50	Estradiol	growth hormone	MESH:D004958	2688	Chemical	Gene	modulates|amod|START_ENTITY END_ENTITY|nsubj|modulates	Estradiol supplementation modulates growth_hormone -LRB- GH -RRB- secretory-burst waveform and recombinant human insulin-like growth factor-I-enforced suppression of endogenously driven GH release in postmenopausal women .
16804038	0	Estradiol	0,9	growth_hormone	51,65	Estradiol	growth hormone	MESH:D004958	2688	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|secretion secretion|compound|END_ENTITY	Estradiol potentiates ghrelin-stimulated pulsatile growth_hormone secretion in postmenopausal women .
18728158	0	Estradiol	0,9	growth_hormone	86,100	Estradiol	growth hormone	MESH:D004958	2688	Chemical	Gene	supplementation|amod|START_ENTITY attenuates|nsubj|supplementation attenuates|dobj|suppression suppression|nmod|END_ENTITY	Estradiol supplementation in postmenopausal women attenuates suppression of pulsatile growth_hormone secretion by recombinant human insulin-like growth factor type I. BACKGROUND : Why pulsatile GH secretion declines in estrogen-deficient postmenopausal individuals remains unknown .
27082452	0	Estradiol	0,9	growth_hormone	100,114	Estradiol	growth hormone	MESH:D004958	2688	Chemical	Gene	stimulate|nsubj|START_ENTITY stimulate|dobj|proliferation proliferation|dep|Proliferation Proliferation|nmod|cells cells|amod|END_ENTITY	Estradiol and corticosterone stimulate the proliferation of a GH cell line , MtT/S : Proliferation of growth_hormone cells .
4046732	0	Estradiol	0,9	growth_hormone	20,34	Estradiol	growth hormone	MESH:D004958	81668(Tax:10116)	Chemical	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	Estradiol increases growth_hormone secretion in rats exposed to swimming stress or reserpine treatment .
7958400	0	Estradiol	0,9	growth_hormone_receptor	19,42	Estradiol	growth hormone receptor	MESH:D004958	100009325(Tax:9986)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Estradiol inhibits growth_hormone_receptor gene expression in rabbit liver .
2282978	0	Estradiol	0,9	heat_shock_protein	50,68	Estradiol	heat shock protein	MESH:D004958	3320	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Estradiol increases phosphorylation of the 90 kDa heat_shock_protein not associated with estradiol receptor in MCF-7 cells in culture .
17261577	0	Estradiol	0,9	heparanase-1	18,30	Estradiol	heparanase-1	MESH:D004958	10855	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Estradiol induces heparanase-1 expression and heparan_sulphate_proteoglycan degradation in human endometrium .
1709814	0	Estradiol	0,9	hepatic_lipase	37,51	Estradiol	hepatic lipase	MESH:D004958	24538(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|secretion secretion|nmod|END_ENTITY	Estradiol increases the secretion of hepatic_lipase by rat hepatocyte cultures .
21901291	0	Estradiol	0,9	hyaluronic_acid_synthase_1	19,45	Estradiol	hyaluronic acid synthase 1	MESH:D004958	3036	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Estradiol inhibits hyaluronic_acid_synthase_1 expression in human vascular smooth muscle cells .
18483013	0	Estradiol	0,9	inducible_nitric_oxide_synthase	44,75	Estradiol	inducible nitric oxide synthase	MESH:D004958	4843	Chemical	Gene	modulate|nsubj|START_ENTITY modulate|dobj|expression expression|amod|END_ENTITY	Estradiol 17-beta and progesterone modulate inducible_nitric_oxide_synthase and high_mobility_group_box_1 expression in human endometrium .
17045571	0	Estradiol	0,9	insulin-like_growth_factor-I	24,52	Estradiol	insulin-like growth factor-I	MESH:D004958	3479	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Estradiol regulates the insulin-like_growth_factor-I -LRB- IGF-I -RRB- signalling pathway : a crucial role of phosphatidylinositol 3-kinase -LRB- PI 3-kinase -RRB- in estrogens requirement for growth of MCF-7 human breast_carcinoma cells .
1944304	0	Estradiol	0,9	insulin-like_growth_factor-I	24,52	Estradiol	insulin-like growth factor-I	MESH:D004958	24482(Tax:10116)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Estradiol regulation of insulin-like_growth_factor-I expression in osteoblastic cells : evidence for transcriptional control .
7867584	0	Estradiol	0,9	insulin-like_growth_factor-I	45,73	Estradiol	insulin-like growth factor-I	MESH:D004958	24482(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|effect effect|nmod|END_ENTITY	Estradiol enhances the stimulatory effect of insulin-like_growth_factor-I -LRB- IGF-I -RRB- on mammary development and growth_hormone-induced IGF-I messenger ribonucleic acid .
19341330	0	Estradiol	0,9	insulin-like_growth_factor_binding_protein-3	71,115	Estradiol	insulin-like growth factor binding protein-3	MESH:D004958	16009(Tax:10090)	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|amod|END_ENTITY	Estradiol , progesterone , and transforming_growth_factor_alpha regulate insulin-like_growth_factor_binding_protein-3 -LRB- IGFBP3 -RRB- expression in mouse endometrial cells .
12518068	0	Estradiol	0,9	lipocalin-type_prostaglandin_D_synthase	35,74	Estradiol	lipocalin-type prostaglandin D synthase	MESH:D004958	19215(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|levels levels|amod|END_ENTITY	Estradiol differentially regulates lipocalin-type_prostaglandin_D_synthase transcript levels in the rodent brain : Evidence from high-density oligonucleotide arrays and in situ hybridization .
1369603	0	Estradiol	0,9	luteinizing_hormone-releasing_hormone	59,96	Estradiol	luteinizing hormone-releasing hormone	MESH:D004958	613033(Tax:9544)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|release release|amod|END_ENTITY	Estradiol enhances the action of neuropeptide_Y on in vivo luteinizing_hormone-releasing_hormone release in the ovariectomized rhesus_monkey .
7690119	0	Estradiol	0,9	luteinizing_hormone-releasing_hormone	114,151	Estradiol	luteinizing hormone-releasing hormone	MESH:D004958	25194(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|parataxis|studies studies|nmod|END_ENTITY	Estradiol modulates the LH release response to N-methyl-D-aspartate in adult female rats : studies on hypothalamic luteinizing_hormone-releasing_hormone and neurotransmitter release .
19264808	0	Estradiol	0,9	miR-21	24,30	Estradiol	miR-21	MESH:D004958	406991	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	Estradiol downregulates miR-21 expression and increases miR-21 target gene expression in MCF-7 breast_cancer cells .
10690908	0	Estradiol	0,9	monocyte_chemotactic_protein-1	42,72	Estradiol	monocyte chemotactic protein-1	MESH:D004958	6347	Chemical	Gene	amplifies|nsubj|START_ENTITY amplifies|dobj|expression expression|amod|END_ENTITY	Estradiol amplifies interleukin-1-induced monocyte_chemotactic_protein-1 expression by ectopic endometrial cells of women with endometriosis .
21914782	0	Estradiol	0,9	natriuretic_peptide_receptor_2	60,90	Estradiol	natriuretic peptide receptor 2	MESH:D004958	230103(Tax:10090)	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|nmod|END_ENTITY	Estradiol promotes and maintains cumulus cell expression of natriuretic_peptide_receptor_2 -LRB- NPR2 -RRB- and meiotic arrest in mouse oocytes in vitro .
20807822	0	Estradiol	0,9	neural_cell_adhesion_molecule	47,76	Estradiol	neural cell adhesion molecule	MESH:D004958	4684	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Estradiol regulates expression of polysialated neural_cell_adhesion_molecule by human vascular endothelial cells .
25255977	0	Estradiol	0,9	osteoprotegerin	18,33	Estradiol	osteoprotegerin	MESH:D004958	4982	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Estradiol induces osteoprotegerin expression by human dental pulp cells .
8726808	0	Estradiol	0,9	p53	21,24	Estradiol	p53	MESH:D004958	7157	Chemical	Gene	influences|nsubj|START_ENTITY influences|dobj|expression expression|compound|END_ENTITY	Estradiol influences p53 expression in a human endometrial_adenocarcinoma heterotransplanted into nude_mice .
26676302	0	Estradiol	0,9	progesterone_receptor	33,54	Estradiol	progesterone receptor	MESH:D004958	18667(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Estradiol differentially induces progesterone_receptor isoforms expression through alternative promoter regulation in a mouse embryonic_hypothalamic cell line .
16595727	0	Estradiol	0,9	prolactin	92,101	Estradiol	prolactin	MESH:D004958	24683(Tax:10116)	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|secretion secretion|compound|END_ENTITY	Estradiol and its membrane-impermeable conjugate estradiol-BSA inhibit tamoxifen-stimulated prolactin secretion in incubated rat pituitaries .
2573549	0	Estradiol	0,9	prolactin	21,30	Estradiol	prolactin	MESH:D004958	24683(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|secretion secretion|amod|END_ENTITY	Estradiol attenuates prolactin secretion and phosphoinositide hydrolysis in MMQ cells .
3586660	0	Estradiol	0,9	prolactin	21,30	Estradiol	prolactin	MESH:D004958	24683(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|transcription transcription|compound|END_ENTITY	Estradiol stimulates prolactin gene transcription in primary cultures of rat anterior pituitary cells .
3942209	0	Estradiol	0,9	prolactin	57,66	Estradiol	prolactin	MESH:D004958	24683(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|shift shift|acl:relcl|release release|dobj|END_ENTITY	Estradiol induces a shift in cultured cells that release prolactin or growth_hormone .
514455	0	Estradiol	0,9	prolactin	30,39	Estradiol	prolactin	MESH:D004958	24683(Tax:10116)	Chemical	Gene	generates|nsubj|START_ENTITY generates|dobj|pulses pulses|nmod|secretion secretion|compound|END_ENTITY	Estradiol generates pulses of prolactin secretion in castrated male rats .
7053988	0	Estradiol	0,9	prolactin	19,28	Estradiol	prolactin	MESH:D004958	5617	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Estradiol inhibits prolactin induced alpha-lactalbumin production in normal primate mammary tissue in vitro .
7061411	0	Estradiol	0,9	prolactin	45,54	Estradiol	prolactin	MESH:D004958	24683(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|nmod|gene gene|compound|END_ENTITY	Estradiol regulates the transcription of the prolactin gene .
7606249	0	Estradiol	0,9	prolactin	132,141	Estradiol	prolactin	MESH:D004958	24683(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|pituitary pituitary|nmod|levels levels|compound|END_ENTITY	Estradiol induces vasoactive intestinal peptide and prolactin gene expression in the rat anterior pituitary independently of plasma prolactin levels .
12477494	0	Estradiol	0,9	prolactin_receptor	45,63	Estradiol	prolactin receptor	MESH:D004958	5618	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|nmod|isoforms isoforms|compound|END_ENTITY	Estradiol stimulates expression of two human prolactin_receptor isoforms with alternative exons-1 in T47D breast_cancer cells .
1620284	0	Estradiol	0,9	proopiomelanocortin	24,43	Estradiol	proopiomelanocortin	MESH:D004958	24664(Tax:10116)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Estradiol regulation of proopiomelanocortin gene expression and peptide content in the hypothalamus .
8083498	0	Estradiol	0,9	renin	28,33	Estradiol	renin	MESH:D004958	443310(Tax:9940)	Chemical	Gene	effects|amod|START_ENTITY END_ENTITY|nsubj|effects	Estradiol effects on plasma renin activity and aldosterone in chronically catheterized castrated sheep .
1935773	0	Estradiol	0,9	secretogranin_II	31,47	Estradiol	secretogranin II	MESH:D004958	24765(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Estradiol negatively regulates secretogranin_II and chromogranin_A messenger ribonucleic_acid levels in the female rat pituitary but not in the adrenal .
10439005	0	Estradiol	0,9	sex_hormone-binding_globulin	38,66	Estradiol	sex hormone-binding globulin	MESH:D004958	6462	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|production production|nmod|END_ENTITY	Estradiol increases the production of sex_hormone-binding_globulin but not insulin-like_growth_factor_binding_protein-1 in cultured human hepatoma cells .
9054366	0	Estradiol	0,9	sex_hormone-binding_globulin	119,147	Estradiol	sex hormone-binding globulin	MESH:D004958	6462	Chemical	Gene	activates|nsubj|START_ENTITY activates|nmod|intermediacy intermediacy|nmod|END_ENTITY	Estradiol activates the prostate androgen receptor and prostate-specific_antigen secretion through the intermediacy of sex_hormone-binding_globulin .
11209068	0	Estradiol	0,9	soluble_guanylyl_cyclase	27,51	Estradiol	soluble guanylyl cyclase	MESH:D004958	497757(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Estradiol rapidly inhibits soluble_guanylyl_cyclase expression in rat uterus .
15312910	0	Estradiol	0,9	spinophilin	18,29	Estradiol	spinophilin	MESH:D004958	84686(Tax:10116)	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|protein protein|compound|END_ENTITY	Estradiol affects spinophilin protein differently in gonadectomized males and females .
10773741	0	Estradiol	0,9	tyrosine_hydroxylase	68,88	Estradiol	tyrosine hydroxylase	MESH:D004958	25085(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|increase increase|nmod|activity activity|compound|END_ENTITY	Estradiol attenuates the forskolin-induced increase in hypothalamic tyrosine_hydroxylase activity .
7912958	0	Estradiol	0,9	tyrosine_hydroxylase	20,40	Estradiol	tyrosine hydroxylase	MESH:D004958	7054	Chemical	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	Estradiol increases tyrosine_hydroxylase activity of the A15 nucleus dopaminergic neurons during long days in the ewe .
14520689	0	Estradiol	0,9	vascular_endothelial_growth_factor	44,78	Estradiol	vascular endothelial growth factor	MESH:D004958	7422	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|nmod|END_ENTITY	Estradiol increases extracellular levels of vascular_endothelial_growth_factor in vivo in murine mammary cancer .
19693777	0	Estradiol	0,9	xanthine_dehydrogenase	20,42	Estradiol	xanthine dehydrogenase	MESH:D004958	7498	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|activity activity|amod|END_ENTITY	Estradiol decreases xanthine_dehydrogenase enzyme activity and protein expression in non-tumorigenic and malignant human mammary epithelial cells .
15280218	0	Estradiol_3-glucuronide	0,23	multidrug_resistance-associated_protein_2	46,87	Estradiol 3-glucuronide	multidrug resistance-associated protein 2	MESH:C025482	25303(Tax:10116)	Chemical	Gene	transported|nsubjpass|START_ENTITY transported|nmod|END_ENTITY	Estradiol_3-glucuronide is transported by the multidrug_resistance-associated_protein_2 but does not activate the allosteric site bound by estradiol_17-glucuronide .
25734362	0	Estradiol_Benzoate	22,40	GnRH	94,98	Estradiol Benzoate	GnRH	MESH:C074283	613033(Tax:9544)	Chemical	Gene	Infusion|nmod|START_ENTITY Infusion|nmod|END_ENTITY	Prolonged Infusion of Estradiol_Benzoate Into the Stalk Median Eminence Stimulates Release of GnRH and Kisspeptin in Ovariectomized Female Rhesus_Macaques .
1371564	0	Estramustine	0,12	prostate_specific_antigen	37,62	Estramustine	prostate specific antigen	MESH:D004961	354	Chemical	Gene	START_ENTITY|dep|use use|nmod|END_ENTITY	Estramustine and vinblastine : use of prostate_specific_antigen as a clinical trial end point for hormone refractory prostatic_cancer .
2501380	0	Estriol	0,7	prolactin	16,25	Estriol	prolactin	MESH:D004964	24683(Tax:10116)	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|secretion secretion|compound|END_ENTITY	Estriol affects prolactin and LH secretion in rats .
26585164	0	Estrogen	52,60	AID	44,47	Estrogen	AID	MESH:D004967	57379	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of Activation_Induced_Deaminase -LRB- AID -RRB- by Estrogen .
26116361	0	Estrogen	34,42	AKT	0,3	Estrogen	AKT	MESH:D004967	207	Chemical	Gene	Function|compound|START_ENTITY Influences|dobj|Function Influences|nsubj|AZD5363 AZD5363|compound|END_ENTITY	AKT Antagonist AZD5363 Influences Estrogen Receptor Function in Endocrine-Resistant Breast Cancer and Synergizes with Fulvestrant -LRB- ICI182780 -RRB- In Vivo .
26783290	0	Estrogen	111,119	AKT	23,26	Estrogen	AKT	MESH:D004967	207	Chemical	Gene	Breast_Cancer|compound|START_ENTITY Women|nmod|Breast_Cancer Therapy|nmod|Women I|nmod|Therapy I|dobj|Study Study|nmod|MK-2206 MK-2206|compound|END_ENTITY	A Phase I Study of the AKT Inhibitor MK-2206 in Combination with Hormonal Therapy in Postmenopausal Women with Estrogen Receptor Positive Metastatic Breast_Cancer .
15544836	0	Estrogen	0,8	AT1	42,45	Estrogen	AT1	MESH:D004967	24180(Tax:10116)	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	Estrogen upregulates renal angiotensin II AT1 and AT2 receptors in the rat .
19477925	0	Estrogen	0,8	ATR	18,21	Estrogen	ATR	MESH:D004967	545	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Estrogen inhibits ATR signaling to cell cycle checkpoints and DNA repair .
26585164	0	Estrogen	52,60	Activation_Induced_Deaminase	14,42	Estrogen	Activation Induced Deaminase	MESH:D004967	57379	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of Activation_Induced_Deaminase -LRB- AID -RRB- by Estrogen .
11435923	0	Estrogen	0,8	Akt	105,108	Estrogen	Akt	MESH:D004967	24185(Tax:10116)	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|activation activation|nmod|END_ENTITY	Estrogen protects against beta-amyloid-induced neurotoxicity in rat hippocampal neurons by activation of Akt .
12657693	0	Estrogen	0,8	Akt	72,75	Estrogen	Akt	MESH:D004967	24185(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY regulate|nsubj|levels regulate|dobj|distribution distribution|nmod|END_ENTITY	Estrogen levels regulate the subcellular distribution of phosphorylated Akt in hippocampal CA1 dendrites .
18258266	3	Estrogen	304,312	Akt	333,336	Estrogen	Akt	MESH:D004967	11651(Tax:10090)	Chemical	Gene	known|nsubjpass|START_ENTITY known|xcomp|augment augment|dobj|END_ENTITY	Estrogen is known to augment Akt , but the possibility that Akt plays a differential role in the male and female brain has yet to be evaluated .
18562618	0	Estrogen	0,8	Akt	56,59	Estrogen	Akt	MESH:D004967	207	Chemical	Gene	facilitates|nsubj|START_ENTITY facilitates|dobj|END_ENTITY	Estrogen facilitates both phosphatidylinositol_3-kinase / Akt and ERK1/2 mitogen-activated protein kinase membrane signaling required for long-term neuropeptide_Y transcriptional regulation in clonal , immortalized neurons .
19287985	0	Estrogen	0,8	Akt	105,108	Estrogen	Akt	MESH:D004967	207	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|advcl|signaling signaling|nsubj|lines lines|nmod|activation activation|nmod|END_ENTITY	Estrogen and progestin regulate HIF-1alpha expression in ovarian_cancer cell lines via the activation of Akt signaling transduction pathway .
24396487	0	Estrogen	0,8	Akt	91,94	Estrogen	Akt	MESH:D004967	207	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|pathway pathway|compound|END_ENTITY	Estrogen protects SGC7901 cells from endoplasmic_reticulum_stress-induced apoptosis by the Akt pathway .
12168011	0	Estrogen	59,67	Angiotensinogen	77,92	Estrogen	angiotensinogen	MESH:D004967	183	Chemical	Gene	START_ENTITY|nmod|Expression Expression|compound|END_ENTITY	Analysis of a cis-Acting Element Involved in Regulation by Estrogen of Human Angiotensinogen Gene Expression .
26372666	0	Estrogen	86,94	Aryl_Hydrocarbon_Receptor	57,82	Estrogen	Aryl Hydrocarbon Receptor	MESH:D004967	25690(Tax:10116)	Chemical	Gene	Signaling|compound|START_ENTITY END_ENTITY|nmod|Signaling	Cross-Talk in the Female Rat Mammary Gland : Influence of Aryl_Hydrocarbon_Receptor on Estrogen Receptor Signaling .
17505058	0	Estrogen	0,8	BCAS3	31,36	Estrogen	BCAS3	MESH:D004967	54828	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Estrogen induces expression of BCAS3 , a novel estrogen_receptor-alpha coactivator , through proline - , glutamic_acid - , and leucine-rich protein-1 -LRB- PELP1 -RRB- .
14502089	0	Estrogen	0,8	BDNF	17,21	Estrogen	BDNF	MESH:D004967	24225(Tax:10116)	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|expression expression|amod|END_ENTITY	Estrogen affects BDNF expression following chronic constriction_nerve_injury .
9655254	0	Estrogen	0,8	BRCA1	25,30	Estrogen	BRCA1	MESH:D004967	672	Chemical	Gene	upregulation|compound|START_ENTITY upregulation|nmod|expression expression|compound|END_ENTITY	Estrogen upregulation of BRCA1 expression with no effect on localization .
10694576	0	Estrogen	0,8	Bcl-2	22,27	Estrogen	Bcl-2	MESH:D004967	12043(Tax:10090)	Chemical	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|induction induction|compound|END_ENTITY	Estrogen up-regulates Bcl-2 and blocks tolerance induction of naive B cells .
11744098	0	Estrogen	0,8	Bcl-2	49,54	Estrogen	Bcl-2	MESH:D004967	596	Chemical	Gene	neuroprotection|compound|START_ENTITY neuroprotection|dep|involvement involvement|nmod|BNIP2 BNIP2|amod|binding binding|amod|END_ENTITY	Estrogen neuroprotection : the involvement of the Bcl-2 binding protein BNIP2 .
16598173	0	Estrogen	0,8	Bcl-2	19,24	Estrogen	Bcl-2	MESH:D004967	24224(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|proteins proteins|compound|END_ENTITY	Estrogen modulates Bcl-2 family proteins in ischemic brain_injury .
18164816	0	Estrogen	0,8	Bcl-2	19,24	Estrogen	Bcl-2	MESH:D004967	24224(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|compound|END_ENTITY	Estrogen modulates Bcl-2 family protein expression in the sexually dimorphic nucleus of the preoptic area of postnatal rats .
18655204	0	Estrogen	0,8	Bcl-2	27,32	Estrogen	Bcl-2	MESH:D004967	24224(Tax:10116)	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|levels levels|nmod|protein protein|compound|END_ENTITY	Estrogen affects levels of Bcl-2 protein and mRNA in medial amygdala of ovariectomized rats .
24971890	0	Estrogen	0,8	Bcl-2	38,43	Estrogen	Bcl-2	MESH:D004967	596	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Estrogen regulation of anti-apoptotic Bcl-2 family member Mcl-1 expression in breast_cancer cells .
7641210	0	Estrogen	0,8	Bcl-2	76,81	Estrogen	Bcl-2	MESH:D004967	596	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|mechanism mechanism|nmod|expression expression|compound|END_ENTITY	Estrogen promotes chemotherapeutic drug resistance by a mechanism involving Bcl-2 proto-oncogene expression in human breast_cancer cells .
9872411	0	Estrogen	0,8	Bcl-2	95,100	Estrogen	Bcl-2	MESH:D004967	12043(Tax:10090)	Chemical	Gene	regression|compound|START_ENTITY prevented|nsubjpass|regression prevented|nmod|END_ENTITY	Estrogen withdrawal-induced human breast_cancer tumour regression in nude_mice is prevented by Bcl-2 .
10098861	0	Estrogen	0,8	Bcl-xL	28,34	Estrogen	Bcl-xL	MESH:D004967	598	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	Estrogen modulates neuronal Bcl-xL expression and beta-amyloid-induced apoptosis : relevance to Alzheimer 's _ disease .
11075820	0	Estrogen	0,8	CAR	51,54	Estrogen	CAR	MESH:D004967	12355(Tax:10090)	Chemical	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Estrogen activation of the nuclear orphan receptor CAR -LRB- constitutive_active_receptor -RRB- in induction of the mouse Cyp2b10 gene .
12378635	0	Estrogen	0,8	CCL4	17,21	Estrogen	CCL4	MESH:D004967	116637(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	Estrogen reduces CCL4 - induced liver fibrosis in rats .
14605002	0	Estrogen	0,8	CCN5	17,21	Estrogen	CCN5	MESH:D004967	29576(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nummod|END_ENTITY	Estrogen induces CCN5 expression in the rat uterus in vivo .
21200384	0	Estrogen	0,8	CD4	35,38	Estrogen	CD4	MESH:D004967	920	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|functions functions|nmod|Foxp3 Foxp3|amod|END_ENTITY	Estrogen enhances the functions of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cells that suppress osteoclast differentiation and bone resorption in vitro .
20869048	0	Estrogen	0,8	CXCL12	54,60	Estrogen	CXCL12	MESH:D004967	6387	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|compound|END_ENTITY	Estrogen induces stromal cell-derived factor 1 -LRB- SDF-1 / CXCL12 -RRB- production in human endometrial stromal cells : a possible role of endometrial epithelial cell growth .
22638611	0	Estrogen	0,8	CYP19A1	25,32	Estrogen	CYP19A1	MESH:D004967	1588	Chemical	Gene	genes|amod|START_ENTITY genes|dep|END_ENTITY	Estrogen synthesis genes CYP19A1 , HSD3B1 , and HSD3B2 in hypertensive disorders of pregnancy .
19107573	0	Estrogen	0,8	DNA_methyltransferase_3B	19,43	Estrogen	DNA methyltransferase 3B	MESH:D004967	1789	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Estrogen regulates DNA_methyltransferase_3B expression in Ishikawa endometrial_adenocarcinoma cells .
23261660	0	Estrogen	0,8	Dkk1	23,27	Estrogen	Dkk1	MESH:D004967	22943	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Estrogen regulation of Dkk1 and Wnt/b-Catenin signaling in neurodegenerative_disease .
24872356	0	Estrogen	0,8	ENaC	19,23	Estrogen	ENaC	MESH:D004967	20276(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|activity activity|amod|END_ENTITY	Estrogen increases ENaC activity via PKC signaling in renal cortical_collecting_duct cells .
16290959	0	Estrogen	87,95	ERA	159,162	Estrogen	ERA	MESH:D004967	2099	Chemical	Gene	Replacement|compound|START_ENTITY Replacement|nmod|Progression Progression|nmod|trial trial|appos|END_ENTITY	Hormone therapy , C-reactive_protein , and progression of atherosclerosis : data from the Estrogen Replacement on Progression of Coronary_Artery_Atherosclerosis -LRB- ERA -RRB- trial .
16375935	0	Estrogen	0,8	ERK1/2	53,59	Estrogen	ERK1/2	MESH:D004967	5595;5594	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Estrogen induces phospholipase A2 activation through ERK1/2 to mobilize intracellular calcium in MCF-7 cells .
22068927	0	Estrogen	0,8	ERK1/2	109,115	Estrogen	ERK1/2	MESH:D004967	5595;5594	Chemical	Gene	receptor|amod|START_ENTITY receptor|dep|estradiol estradiol|nmod|END_ENTITY	Estrogen receptor -LRB- ER -RRB- expression and function in the pregnant human myometrium : estradiol via ERa activates ERK1/2 signaling in term myometrium .
23024694	0	Estrogen	79,87	ERK1/2	128,134	Estrogen	ERK1/2	MESH:D004967	50689;116590	Chemical	Gene	Receptors|compound|START_ENTITY Receptors|nmod|Activation Activation|nmod|END_ENTITY	Ginsenoside_Rb1 Prevents MPP -LRB- + -RRB- - Induced Apoptosis in PC12 Cells by Stimulating Estrogen Receptors with Consequent Activation of ERK1/2 , Akt and Inhibition of SAPK/JNK , p38 MAPK .
26069273	0	Estrogen	0,8	ERK1/2	46,52	Estrogen	ERK1/2	MESH:D004967	5595;5594	Chemical	Gene	ESR1|compound|START_ENTITY mediates|nsubj|ESR1 mediates|dobj|activation activation|nmod|END_ENTITY	Estrogen receptor ESR1 mediates activation of ERK1/2 , CREB , and ELK1 in the corpus_of_the_epididymis .
18234909	0	Estrogen	0,8	ERRalpha	42,50	Estrogen	ERRalpha	MESH:D004967	2101	Chemical	Gene	alpha|amod|START_ENTITY alpha|appos|END_ENTITY	Estrogen receptor-related receptor alpha -LRB- ERRalpha -RRB- regulates osteopontin expression through a non-canonical ERRalpha response element in a cell context-dependent manner .
20446107	0	Estrogen	15,23	ER_beta	68,75	Estrogen	ER beta	MESH:D004967	13983(Tax:10090)	Chemical	Gene	140|compound|START_ENTITY 140|nmod|END_ENTITY	Interaction of Estrogen Receptor Associated Protein -LRB- ERAP -RRB- 140 with ER_beta decreases but its expression increases in aging mouse cerebral cortex .
22068927	0	Estrogen	0,8	ERa	95,98	Estrogen	ERa	MESH:D004967	2099	Chemical	Gene	receptor|amod|START_ENTITY receptor|dep|estradiol estradiol|nmod|ERK1/2 ERK1/2|compound|END_ENTITY	Estrogen receptor -LRB- ER -RRB- expression and function in the pregnant human myometrium : estradiol via ERa activates ERK1/2 signaling in term myometrium .
23804112	0	Estrogen	0,8	ERa	83,86	Estrogen	ERa	MESH:D004967	13982(Tax:10090)	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Estrogen mediates neuroprotection and anti-inflammatory effects during EAE through ERa signaling on astrocytes but not through ERb signaling on astrocytes or neurons .
24188405	0	Estrogen	0,8	ERa	20,23	Estrogen	ERa	MESH:D004967	2099	Chemical	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Estrogen receptors -LRB- ERa versus ERb -RRB- : friends or foes in human biology ?
26152119	0	Estrogen	0,8	ERa	81,84	Estrogen	ERa	MESH:D004967	13982(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|activating activating|dobj|END_ENTITY	Estrogen induces two distinct cholesterol crystallization pathways by activating ERa and GPR30 in female mice .
26487511	0	Estrogen	56,64	ERa	9,12	Estrogen	ERa	MESH:D004967	26284	Chemical	Gene	Complex|compound|START_ENTITY Effects|nmod|Complex END_ENTITY|dep|Effects	The Dual ERa Inhibitory Effects of the Tissue-Selective Estrogen Complex for Endometrial and Breast Safety .
26744532	0	Estrogen	135,143	ERa	32,35	Estrogen	ERa	MESH:D004967	2099	Chemical	Gene	Cells|nmod|START_ENTITY Infiltrating|nmod|Cells Infiltrating|dobj|Expression Expression|compound|END_ENTITY	Infiltrating Macrophages Induce ERa Expression through an IL17A-mediated Epigenetic Mechanism to Sensitize Endometrial_Cancer Cells to Estrogen .
26917440	0	Estrogen	27,35	ERa	68,71	Estrogen	ERa	MESH:D004967	13982(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Osteoprotective Effects of Estrogen in the Maxillary Bone Depend on ERa .
10537130	0	Estrogen	0,8	ERalpha	111,118	Estrogen	ERalpha	MESH:D004967	24890(Tax:10116)	Chemical	Gene	respresses|nsubj|START_ENTITY respresses|dobj|gene gene|appos|END_ENTITY	Estrogen directly respresses gonadotropin-releasing_hormone -LRB- GnRH -RRB- gene expression in estrogen receptor-alpha -LRB- ERalpha -RRB- - and ERbeta-expressing GT1-7 GnRH neurons .
10623650	0	Estrogen	0,8	ERalpha	43,50	Estrogen	ERalpha	MESH:D004967	2099	Chemical	Gene	beta|compound|START_ENTITY coexpressed|nsubjpass|beta coexpressed|nmod|END_ENTITY	Estrogen receptor beta is coexpressed with ERalpha and PR and associated with nodal status , grade , and proliferation rate in breast_cancer .
10683408	0	Estrogen	0,8	ERalpha	57,64	Estrogen	ERalpha	MESH:D004967	24890(Tax:10116)	Chemical	Gene	binding|nmod:npmod|START_ENTITY binding|appos|END_ENTITY	Estrogen binding and estrogen receptor characterization -LRB- ERalpha and ERbeta -RRB- in the cholinergic neurons of the rat basal forebrain .
14505348	0	Estrogen	0,8	ERalpha	127,134	Estrogen	ERalpha	MESH:D004967	2099	Chemical	Gene	regulation|compound|START_ENTITY regulation|acl|expressing expressing|dobj|END_ENTITY	Estrogen receptor isoform-specific regulation of endogenous gene expression in human osteoblastic cell lines expressing either ERalpha or ERbeta .
15285303	0	Estrogen	0,8	ERalpha	112,119	Estrogen	ERalpha	MESH:D004967	2099	Chemical	Gene	beta|compound|START_ENTITY expression|compound|beta correlated|nsubjpass|expression correlated|nmod|estrogen_receptor_alpha estrogen_receptor_alpha|appos|END_ENTITY	Estrogen receptor beta -LRB- ERbeta -RRB- expression in breast_carcinomas is not correlated with estrogen_receptor_alpha -LRB- ERalpha -RRB- and prognosis : the Greek experience .
15345745	0	Estrogen	0,8	ERalpha	154,161	Estrogen	ERalpha	MESH:D004967	2099	Chemical	Gene	receptor|compound|START_ENTITY receptor|dep|effects effects|nmod|END_ENTITY	Estrogen receptor -LRB- ER -RRB- - mediated transcriptional regulation of the human corticotropin-releasing hormone-binding protein promoter : differential effects of ERalpha and ERbeta .
15530885	0	Estrogen	0,8	ERalpha	119,126	Estrogen	ERalpha	MESH:D004967	13982(Tax:10090)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|nmod|lack lack|nmod|receptors receptors|appos|END_ENTITY	Estrogen attenuates the MPTP-induced loss of dopamine neurons from the mouse SNc despite a lack of estrogen receptors -LRB- ERalpha and ERbeta -RRB- .
15772903	0	Estrogen	0,8	ERalpha	62,69	Estrogen	ERalpha	MESH:D004967	407238(Tax:9913)	Chemical	Gene	beta|compound|START_ENTITY expressed|nsubjpass|beta expressed|nmod|END_ENTITY	Estrogen receptor beta -LRB- ERbeta -RRB- is expressed differently from ERalpha in bovine placentomes .
16007178	0	Estrogen	0,8	ERalpha	25,32	Estrogen	ERalpha	MESH:D004967	2099	Chemical	Gene	alfa|compound|START_ENTITY alfa|appos|END_ENTITY	Estrogen receptors alfa -LRB- ERalpha -RRB- and beta -LRB- ERbeta -RRB- differentially regulate proliferation and apoptosis of the normal murine mammary epithelial cell line HC11 .
16126407	0	Estrogen	0,8	ERalpha	62,69	Estrogen	ERalpha	MESH:D004967	2099	Chemical	Gene	action|amod|START_ENTITY action|nmod|formation formation|nmod|END_ENTITY	Estrogen rapid action via protein complex formation involving ERalpha and Src .
19668239	0	Estrogen	0,8	ERalpha	131,138	Estrogen	ERalpha	MESH:D004967	2099	Chemical	Gene	treatment|compound|START_ENTITY decreases|nsubj|treatment decreases|nmod|estrogen_receptor_alpha estrogen_receptor_alpha|appos|END_ENTITY	Estrogen treatment decreases matrix_metalloproteinase _ -LRB- MMP -RRB- -9 in autoimmune_demyelinating_disease through estrogen_receptor_alpha -LRB- ERalpha -RRB- .
22810004	0	Estrogen	0,8	ERb	24,27	Estrogen	ERb	MESH:D004967	2100	Chemical	Gene	beta|compound|START_ENTITY beta|appos|END_ENTITY	Estrogen receptor beta -LRB- ERb -RRB- produces autophagy and necroptosis in human seminoma cell line through the binding of the Sp1 on the phosphatase and tensin homolog deleted from chromosome 10 -LRB- PTEN -RRB- promoter gene .
23150547	0	Estrogen	0,8	ERb	42,45	Estrogen	ERb	MESH:D004967	13983(Tax:10090)	Chemical	Gene	function|amod|START_ENTITY function|nmod|END_ENTITY	Estrogen dependent activation function of ERb is essential for the sexual behavior of mouse females .
11457488	0	Estrogen	0,8	ERbeta	24,30	Estrogen	ERbeta	MESH:D004967	574110(Tax:9544)	Chemical	Gene	beta|compound|START_ENTITY beta|appos|END_ENTITY	Estrogen receptor beta -LRB- ERbeta -RRB- mRNA and protein in serotonin neurons of macaques .
15141349	0	Estrogen	0,8	ERbeta	24,30	Estrogen	ERbeta	MESH:D004967	2100	Chemical	Gene	beta|compound|START_ENTITY beta|appos|END_ENTITY	Estrogen receptor beta -LRB- ERbeta -RRB- is expressed in brain astrocytic_tumors and declines with dedifferentiation_of_the_neoplasm .
15285303	0	Estrogen	0,8	ERbeta	24,30	Estrogen	ERbeta	MESH:D004967	2100	Chemical	Gene	beta|compound|START_ENTITY beta|appos|END_ENTITY	Estrogen receptor beta -LRB- ERbeta -RRB- expression in breast_carcinomas is not correlated with estrogen_receptor_alpha -LRB- ERalpha -RRB- and prognosis : the Greek experience .
15722789	0	Estrogen	0,8	ERbeta	62,68	Estrogen	ERbeta	MESH:D004967	2100	Chemical	Gene	beta|compound|START_ENTITY beta|dep|associations associations|nmod|END_ENTITY	Estrogen receptor beta in breast_cancer : associations between ERbeta , hormonal receptors , and other prognostic biomarkers .
15772903	0	Estrogen	0,8	ERbeta	24,30	Estrogen	ERbeta	MESH:D004967	281146(Tax:9913)	Chemical	Gene	beta|compound|START_ENTITY beta|appos|END_ENTITY	Estrogen receptor beta -LRB- ERbeta -RRB- is expressed differently from ERalpha in bovine placentomes .
15882902	0	Estrogen	0,8	ERbeta	144,150	Estrogen	ERbeta	MESH:D004967	25149(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|nmod|receptor-beta receptor-beta|appos|END_ENTITY	Estrogen stimulates galanin expression within luteinizing_hormone-releasing_hormone-immunoreactive -LRB- LHRH-i -RRB- neurons via estrogen receptor-beta -LRB- ERbeta -RRB- in the female rat brain .
16292491	0	Estrogen	0,8	ERbeta	24,30	Estrogen	ERbeta	MESH:D004967	2100	Chemical	Gene	beta|compound|START_ENTITY beta|appos|END_ENTITY	Estrogen receptor beta -LRB- ERbeta -RRB- protein expression correlates with BAG-1 and prognosis in brain_glial_tumours .
17023111	0	Estrogen	0,8	ERbeta	24,30	Estrogen	ERbeta	MESH:D004967	2100	Chemical	Gene	beta|compound|START_ENTITY beta|appos|END_ENTITY	Estrogen receptor beta -LRB- ERbeta -RRB- and inhibition of prostate_cancer cell proliferation : studies on the possible mechanism of action in DU145 cells .
19460433	0	Estrogen	0,8	ERbeta	24,30	Estrogen	ERbeta	MESH:D004967	2100	Chemical	Gene	receptor|nsubj|START_ENTITY receptor|dobj|activation activation|appos|END_ENTITY	Estrogen receptor beta -LRB- ERbeta -RRB- subtype-specific ligands increase transcription , p44/p42 mitogen activated protein kinase -LRB- MAPK -RRB- activation and growth in human non-small_cell_lung_cancer cells .
16939403	0	Estrogen	0,8	ESR1	89,93	Estrogen	ESR1	MESH:D004967	2099	Chemical	Gene	polymorphisms|amod|START_ENTITY polymorphisms|nmod|interaction interaction|nmod|estrogen_receptor_alpha estrogen_receptor_alpha|appos|END_ENTITY	Estrogen receptor beta -LRB- ESR2 -RRB- polymorphisms in interaction with estrogen_receptor_alpha -LRB- ESR1 -RRB- and insulin-like_growth_factor_I -LRB- IGF1 -RRB- variants influence the risk of fracture in postmenopausal women .
18569528	0	Estrogen	0,8	ESR1	26,30	Estrogen	ESR1	MESH:D004967	2099	Chemical	Gene	alpha|compound|START_ENTITY alpha|appos|END_ENTITY	Estrogen receptors alpha -LRB- ESR1 -RRB- and beta -LRB- ESR2 -RRB- are expressed in circulating human lymphocytes .
22367588	0	Estrogen	0,8	ESR1	59,63	Estrogen	ESR1	MESH:D004967	13982(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY offsets|nsubj|receptor offsets|dobj|absence absence|nmod|END_ENTITY	Estrogen receptor -LRB- ESR -RRB- 2 partially offsets the absence of ESR1 in gonadotropes of pituitary-specific Esr1 knockout female mice .
25979954	0	Estrogen	76,84	ESR1	57,61	Estrogen	ESR1	MESH:D004967	2099	Chemical	Gene	Breast_Cancer|compound|START_ENTITY Mutations|nmod|Breast_Cancer Mutations|appos|END_ENTITY	Noninvasive Detection of Activating Estrogen_Receptor_1 -LRB- ESR1 -RRB- Mutations in Estrogen Receptor-Positive Metastatic Breast_Cancer .
15280642	0	Estrogen	0,8	ESR2	24,28	Estrogen	ESR2	MESH:D004967	2100	Chemical	Gene	beta|compound|START_ENTITY beta|appos|END_ENTITY	Estrogen receptor beta -LRB- ESR2 -RRB- polymorphisms and endometrial_cancer -LRB- United States -RRB- .
16261413	0	Estrogen	0,8	ESR2	24,28	Estrogen	ESR2	MESH:D004967	2100	Chemical	Gene	beta|compound|START_ENTITY beta|appos|END_ENTITY	Estrogen receptor beta -LRB- ESR2 -RRB- polymorphisms in familial and sporadic breast_cancer .
16939403	0	Estrogen	0,8	ESR2	24,28	Estrogen	ESR2	MESH:D004967	2100	Chemical	Gene	polymorphisms|amod|START_ENTITY polymorphisms|appos|END_ENTITY	Estrogen receptor beta -LRB- ESR2 -RRB- polymorphisms in interaction with estrogen_receptor_alpha -LRB- ESR1 -RRB- and insulin-like_growth_factor_I -LRB- IGF1 -RRB- variants influence the risk of fracture in postmenopausal women .
20135064	0	Estrogen	0,8	Endoglin	93,101	Estrogen	Endoglin	MESH:D004967	2022	Chemical	Gene	therapy|compound|START_ENTITY therapy|nmod|END_ENTITY	Estrogen therapy for hereditary_haemorrhagic_telangiectasia -LRB- HHT -RRB- : Effects of raloxifene , on Endoglin and ALK1 expression in endothelial cells .
23227363	0	Estrogen	0,8	Erythropoietin	40,54	Estrogen	Erythropoietin	MESH:D004967	24335(Tax:10116)	Chemical	Gene	Abolishes|nsubj|START_ENTITY Abolishes|dobj|Effect Effect|nmod|END_ENTITY	Estrogen Abolishes Protective Effect of Erythropoietin against Cisplatin-Induced Nephrotoxicity in Ovariectomized Rats .
22367588	0	Estrogen	0,8	Esr1	102,106	Estrogen	Esr1	MESH:D004967	13982(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY offsets|nsubj|receptor offsets|nmod|gonadotropes gonadotropes|nmod|mice mice|amod|END_ENTITY	Estrogen receptor -LRB- ESR -RRB- 2 partially offsets the absence of ESR1 in gonadotropes of pituitary-specific Esr1 knockout female mice .
12174283	0	Estrogen	60,68	Estrogen_Receptor	39,56	Estrogen	Estrogen Receptor	MESH:D004967	2099	Chemical	Gene	Element|compound|START_ENTITY Enhance|nmod|Element Enhance|dobj|Binding Binding|nmod|END_ENTITY	Nuclear Factors Enhance the Binding of Estrogen_Receptor to Estrogen Response Element .
25633552	0	Estrogen	0,8	Estrogen_Receptor_Alpha	58,81	Estrogen	Estrogen Receptor Alpha	MESH:D004967	2099	Chemical	Gene	Regulation|compound|START_ENTITY Regulation|dep|Role Role|nmod|END_ENTITY	Estrogen and Body Weight Regulation in Women : The Role of Estrogen_Receptor_Alpha -LRB- ER-a -RRB- on Adipocyte Lipolysis .
17803905	0	Estrogen	0,8	Fas_ligand	73,83	Estrogen	Fas ligand	MESH:D004967	14103(Tax:10090)	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|dobj|bone_loss bone_loss|nmod|END_ENTITY	Estrogen prevents bone_loss via estrogen_receptor_alpha and induction of Fas_ligand in osteoclasts .
18219273	0	Estrogen	0,8	Fas_ligand	35,45	Estrogen	Fas ligand	MESH:D004967	356	Chemical	Gene	protects|nsubj|START_ENTITY protects|advcl|inducing inducing|dobj|END_ENTITY	Estrogen protects bone by inducing Fas_ligand in osteoblasts to regulate osteoclast survival .
26062603	0	Estrogen	0,8	Fas_ligand	19,29	Estrogen	Fas ligand	MESH:D004967	356	Chemical	Gene	preserves|nsubj|START_ENTITY preserves|dobj|levels levels|compound|END_ENTITY	Estrogen preserves Fas_ligand levels by inhibiting microRNA-181a in bone marrow-derived mesenchymal stem cells to maintain bone remodeling balance .
26817205	0	Estrogen	0,8	GDNF	28,32	Estrogen	GDNF	MESH:D004967	14573(Tax:10090)	Chemical	Gene	Immunoreactivity|compound|START_ENTITY Immunoreactivity|compound|END_ENTITY	Estrogen Increases Striatal GDNF Immunoreactivity with no Effect on Striatal FGF-2 Immunoreactivity of MPTP-Treated Mice .
11095449	0	Estrogen	0,8	GH	43,45	Estrogen	GH	MESH:D004967	2688	Chemical	Gene	effect|compound|START_ENTITY effect|nmod|test test|amod|growth_hormone growth_hormone|dep|END_ENTITY	Estrogen priming effect on growth_hormone -LRB- GH -RRB- provocative test : a useful tool for the diagnosis of GH_deficiency .
12552091	0	Estrogen	0,8	GH	18,20	Estrogen	GH	MESH:D004967	2688	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation , an effect mediated by SOCS-2 .
26199431	0	Estrogen	0,8	GH	147,149	Estrogen	GH	MESH:D004967	2688	Chemical	Gene	Antagonism|compound|START_ENTITY uncovers|nsubj|Antagonism uncovers|nmod|END_ENTITY	Estrogen Receptor Antagonism uncovers gender-dimorphic suppression of whole body fat oxidation in humans : differential effects of tamoxifen on the GH and gonadal axes .
26199431	0	Estrogen	0,8	GH	147,149	Estrogen	GH	MESH:D004967	2688	Chemical	Gene	Antagonism|compound|START_ENTITY uncovers|nsubj|Antagonism uncovers|nmod|END_ENTITY	Estrogen Receptor Antagonism uncovers gender-dimorphic suppression of whole body fat oxidation in humans : differential effects of tamoxifen on the GH and gonadal axes .
24530924	0	Estrogen	0,8	GPER	36,40	Estrogen	GPER	MESH:D004967	76854(Tax:10090)	Chemical	Gene	biology|compound|START_ENTITY biology|dep|insights insights|nmod|function function|amod|END_ENTITY	Estrogen biology : new insights into GPER function and clinical opportunities .
25893606	0	Estrogen	0,8	GPER	39,43	Estrogen	GPER	MESH:D004967	2852	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|signaling signaling|nmod|END_ENTITY	Estrogen regulates Hippo signaling via GPER in breast_cancer .
26432358	0	Estrogen	0,8	GPER	56,60	Estrogen	GPER	MESH:D004967	2852	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|axis axis|compound|END_ENTITY	Estrogen suppresses breast_cancer proliferation through GPER / p38 MAPK axis during hypoxia .
26536245	0	Estrogen	29,37	GPER	48,52	Estrogen	GPER	MESH:D004967	171104(Tax:10116)	Chemical	Gene	Receptor|compound|START_ENTITY Receptor|appos|END_ENTITY	Pregnancy Augments G Protein Estrogen Receptor -LRB- GPER -RRB- Induced Vasodilation in Rat Uterine Arteries via the Nitric_Oxide - cGMP Signaling Pathway .
26585158	0	Estrogen	37,45	GPER	0,4	Estrogen	GPER	MESH:D004967	2852	Chemical	Gene	Effects|nmod|START_ENTITY Effects|compound|END_ENTITY	GPER Mediates Non-Genomic Effects of Estrogen .
18271749	0	Estrogen	0,8	GPR30	72,77	Estrogen	GPR30	MESH:D004967	2852	Chemical	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Estrogen signaling through the transmembrane G protein-coupled receptor GPR30 .
19344720	0	Estrogen	0,8	GPR30	84,89	Estrogen	GPR30	MESH:D004967	171104(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|visceral_hypersensitivity visceral_hypersensitivity|nmod|END_ENTITY	Estrogen rapidly modulates 5-hydroxytrytophan-induced visceral_hypersensitivity via GPR30 in rats .
21655374	0	Estrogen	17,25	GPR30	68,73	Estrogen	GPR30	MESH:D004967	2852	Chemical	Gene	Receptor|compound|START_ENTITY Receptor|appos|G_Protein G_Protein|dep|Coupled_Receptor_30 Coupled_Receptor_30|appos|END_ENTITY	The Cell Surface Estrogen Receptor , G_Protein - _ Coupled_Receptor_30 -LRB- GPR30 -RRB- , is Markedly Down Regulated During Breast Tumorigenesis .
24440569	0	Estrogen	0,8	GPR30	170,175	Estrogen	GPR30	MESH:D004967	2852	Chemical	Gene	fulvestrant|compound|START_ENTITY augment|nsubj|fulvestrant augment|nmod|protein protein|acl|coupled coupled|dobj|receptor receptor|appos|END_ENTITY	Estrogen and pure antiestrogen fulvestrant -LRB- ICI_182_780 -RRB- augment cell-matrigel adhesion of MCF-7 breast_cancer cells through a novel G protein coupled estrogen receptor -LRB- GPR30 -RRB- - to-calpain signaling axis .
25820689	0	Estrogen	34,42	GPR30	0,5	Estrogen	GPR30	MESH:D004967	76854(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Mediates|dobj|Effect Mediates|nsubj|END_ENTITY	GPR30 Mediates the Fast Effect of Estrogen on Mouse Blastocyst and its Role in Implantation .
26731262	0	Estrogen	46,54	GPR30	56,61	Estrogen	GPR30	MESH:D004967	2852	Chemical	Gene	Inhibition|nmod|START_ENTITY Pathway|nmod|Inhibition Pathway|parataxis|Leads Leads|nsubj|Activation Activation|compound|END_ENTITY	A New Signaling Pathway for HCV Inhibition by Estrogen : GPR30 Activation Leads to Cleavage of Occludin by MMP-9 .
24062489	0	Estrogen	0,8	G_protein-coupled_estrogen_receptor	31,66	Estrogen	G protein-coupled estrogen receptor	MESH:D004967	2852	Chemical	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Estrogen signaling through the G_protein-coupled_estrogen_receptor regulates granulocyte activation in fish .
24921706	0	Estrogen	0,8	G_protein-coupled_estrogen_receptor	87,122	Estrogen	G protein-coupled estrogen receptor	MESH:D004967	171104(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Estrogen rapidly enhances incisional pain of ovariectomized rats primarily through the G_protein-coupled_estrogen_receptor .
26850467	0	Estrogen	0,8	G_protein-coupled_receptor_30	139,168	Estrogen	G protein-coupled receptor 30	MESH:D004967	2852	Chemical	Gene	involves|nsubj|START_ENTITY involves|dobj|crosstalk crosstalk|nmod|beta beta|compound|END_ENTITY	Estrogen stimulated migration and invasion of estrogen_receptor-negative breast_cancer cells involves an ezrin-dependent crosstalk between G_protein-coupled_receptor_30 and estrogen_receptor beta signaling .
10537130	0	Estrogen	0,8	GnRH	61,65	Estrogen	GnRH	MESH:D004967	25194(Tax:10116)	Chemical	Gene	respresses|nsubj|START_ENTITY respresses|dobj|gene gene|appos|END_ENTITY	Estrogen directly respresses gonadotropin-releasing_hormone -LRB- GnRH -RRB- gene expression in estrogen receptor-alpha -LRB- ERalpha -RRB- - and ERbeta-expressing GT1-7 GnRH neurons .
15062568	0	Estrogen	0,8	GnRH	24,28	Estrogen	GnRH	MESH:D004967	2796	Chemical	Gene	down-regulates|compound|START_ENTITY END_ENTITY|nsubj|down-regulates	Estrogen down-regulates GnRH gene expression in human placental cytotrophoblast cells .
19428988	0	Estrogen	0,8	GnRH	42,46	Estrogen	GnRH	MESH:D004967	14714(Tax:10090)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|nmod|END_ENTITY	Estrogen regulation of gene expression in GnRH neurons .
8674569	0	Estrogen	0,8	GnRH	46,50	Estrogen	GnRH	MESH:D004967	2796	Chemical	Gene	content|compound|START_ENTITY content|nmod|END_ENTITY	Estrogen and progesterone_receptor content of GnRH analogue pretreated and untreated uterine_leiomyomata .
26729430	0	Estrogen	11,19	Gonadotropin-Releasing_Hormone	37,67	Estrogen	Gonadotropin-Releasing Hormone	MESH:D004967	2796	Chemical	Gene	Suppression|nsubj|START_ENTITY Suppression|nmod|Efficacy Efficacy|compound|END_ENTITY	Incomplete Estrogen Suppression With Gonadotropin-Releasing_Hormone Agonists May Reduce Clinical Efficacy in Premenopausal Women With Early Breast Cancer .
19287985	0	Estrogen	0,8	HIF-1alpha	32,42	Estrogen	HIF-1alpha	MESH:D004967	3091	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|compound|END_ENTITY	Estrogen and progestin regulate HIF-1alpha expression in ovarian_cancer cell lines via the activation of Akt signaling transduction pathway .
11788335	0	Estrogen	0,8	HSP70	33,38	Estrogen	HSP70	MESH:D004967	266759(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|compound|END_ENTITY	Estrogen attenuates postexercise HSP70 expression in skeletal muscle .
22427208	0	Estrogen	0,8	IGF-1	25,30	Estrogen	IGF-1	MESH:D004967	3479	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	Estrogen upregulates the IGF-1 signaling pathway in lung_cancer through estrogen receptor-b .
12944101	0	Estrogen	0,8	IGF-I	124,129	Estrogen	IGF-I	MESH:D004967	3479	Chemical	Gene	agonists/antagonists|compound|START_ENTITY growth_hormone|nsubj|agonists/antagonists growth_hormone|xcomp|signaling signaling|nmod|hepatocytes hepatocytes|dep|explanation explanation|nmod|impact impact|nmod|END_ENTITY	Estrogen agonists/antagonists may down-regulate growth_hormone signaling in hepatocytes -- an explanation for their impact on IGF-I , IGFBP-1 , and lipoprotein -LRB- a -RRB- .
23094148	0	Estrogen	0,8	IGF-I	90,95	Estrogen	IGF-I	MESH:D004967	3479	Chemical	Gene	Genes|compound|START_ENTITY Genes|nmod|Kinase Kinase|compound|END_ENTITY	Estrogen Regulates MAPK-Related Genes through Genomic and Nongenomic Interactions between IGF-I Receptor Tyrosine Kinase and Estrogen_Receptor-Alpha Signaling Pathways in Human Uterine Leiomyoma Cells .
9264503	0	Estrogen	0,8	IGF-I	50,55	Estrogen	IGF-I	MESH:D004967	100008668(Tax:9986)	Chemical	Gene	effects|compound|START_ENTITY effects|nmod|insulin-like_growth_factor-I insulin-like_growth_factor-I|appos|END_ENTITY	Estrogen effects on insulin-like_growth_factor-I -LRB- IGF-I -RRB- - induced cell proliferation and IGF-I expression in native and allograft vessels .
16939403	0	Estrogen	0,8	IGF1	129,133	Estrogen	IGF1	MESH:D004967	3479	Chemical	Gene	polymorphisms|amod|START_ENTITY polymorphisms|nmod|interaction interaction|nmod|estrogen_receptor_alpha estrogen_receptor_alpha|appos|END_ENTITY	Estrogen receptor beta -LRB- ESR2 -RRB- polymorphisms in interaction with estrogen_receptor_alpha -LRB- ESR1 -RRB- and insulin-like_growth_factor_I -LRB- IGF1 -RRB- variants influence the risk of fracture in postmenopausal women .
24960169	0	Estrogen	0,8	IL-6	30,34	Estrogen	IL-6	MESH:D004967	16193(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	Estrogen inhibits LPS-induced IL-6 production in macrophages partially via the nongenomic pathway .
17656465	0	Estrogen	0,8	KiSS1	19,24	Estrogen	KiSS1	MESH:D004967	3814	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Estrogen regulates KiSS1 gene expression through estrogen_receptor_alpha and SP protein complexes .
2956530	0	Estrogen	0,8	LHRH	108,112	Estrogen	LHRH	MESH:D004967	25194(Tax:10116)	Chemical	Gene	priming|compound|START_ENTITY affects|nsubj|priming affects|xcomp|microiontophoretically microiontophoretically|dobj|END_ENTITY	Estrogen priming affects the sensitivity of midbrain central gray neurons to microiontophoretically applied LHRH but not beta-endorphin .
6816851	0	Estrogen	0,8	LHRH	32,36	Estrogen	LHRH	MESH:D004967	2796	Chemical	Gene	induced|nsubj|START_ENTITY induced|dobj|enhancement enhancement|nmod|clearance clearance|compound|END_ENTITY	Estrogen induced enhancement of LHRH clearance in amenorrheic women .
23870474	0	Estrogen	0,8	MMP2/9	22,28	Estrogen	MMP2/9	MESH:D004967	4313;4318	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Estrogen up-regulates MMP2/9 expression in endometrial epithelial cell via VEGF-ERK1 / 2 pathway .
12972607	0	Estrogen	0,8	NF-kappaB	28,37	Estrogen	NF-kappaB	MESH:D004967	4790	Chemical	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Estrogen withdrawal-induced NF-kappaB activity and bcl-3 expression in breast_cancer cells : roles in growth and hormone independence .
24796879	0	Estrogen	0,8	Ndrg2	37,42	Estrogen	Ndrg2	MESH:D004967	29811(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Estrogen regulates the expression of Ndrg2 in astrocytes .
25172557	0	Estrogen	0,8	Nrf2	19,23	Estrogen	Nrf2	MESH:D004967	4780	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|activity activity|amod|END_ENTITY	Estrogen increases Nrf2 activity through activation of the PI3K pathway in MCF-7 breast_cancer cells .
25665485	0	Estrogen	15,23	PCSK9	68,73	Estrogen	PCSK9	MESH:D004967	255738	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	The Effects of Estrogen on Serum Level and Hepatocyte Expression of PCSK9 .
2404751	1	Estrogen	174,182	PR	257,259	Estrogen	PR	MESH:D004967	5241	Chemical	Gene	known|nsubjpass|START_ENTITY known|xcomp|stimulator stimulator|nmod|synthesis synthesis|appos|END_ENTITY	Estrogen -LRB- E -RRB- is well known to be an important stimulator of progesterone_receptor -LRB- PR -RRB- synthesis in target cells .
19748493	0	Estrogen	0,8	PTEN	34,38	Estrogen	PTEN	MESH:D004967	5728	Chemical	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|END_ENTITY	Estrogen partially down-regulates PTEN to prevent apoptosis in VSC4 .1 motoneurons following exposure to IFN-gamma .
9632110	0	Estrogen	0,8	PTHrP	20,25	Estrogen	PTHrP	MESH:D004967	24695(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Estrogen stimulates PTHrP but not PTH/PTHrP receptor gene expression in the kidney of ovariectomized rat .
12560069	0	Estrogen	0,8	Pak1	23,27	Estrogen	Pak1	MESH:D004967	5058	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Estrogen regulation of Pak1 and FKHR pathways in breast_cancer cells .
26691151	0	Estrogen	8,16	Prolactin	47,56	Estrogen	Prolactin	MESH:D004967	5617	Chemical	Gene	Element|compound|START_ENTITY Element|nmod|Gene Gene|compound|END_ENTITY	Role of Estrogen Response Element in the Human Prolactin Gene : Transcriptional Response and Timing .
20869048	0	Estrogen	0,8	SDF-1	48,53	Estrogen	SDF-1	MESH:D004967	6387	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|compound|END_ENTITY	Estrogen induces stromal cell-derived factor 1 -LRB- SDF-1 / CXCL12 -RRB- production in human endometrial stromal cells : a possible role of endometrial epithelial cell growth .
26015225	0	Estrogen	0,8	SOX4	36,40	Estrogen	SOX4	MESH:D004967	6659	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Estrogen induces androgen-repressed SOX4 expression to promote progression of prostate_cancer cells .
17230544	0	Estrogen	0,8	SULT1E1	27,34	Estrogen	SULT1E1	MESH:D004967	6783	Chemical	Gene	sulfotransferase|compound|START_ENTITY sulfotransferase|appos|END_ENTITY	Estrogen sulfotransferase -LRB- SULT1E1 -RRB- expression in benign and malignant human bone_tumors .
23384540	0	Estrogen	0,8	SULT1E1	27,34	Estrogen	SULT1E1	MESH:D004967	6783	Chemical	Gene	sulfotransferase|compound|START_ENTITY sulfotransferase|appos|END_ENTITY	Estrogen sulfotransferase -LRB- SULT1E1 -RRB- regulates inflammatory response and lipid metabolism of human endothelial cells via PPARy .
25837159	0	Estrogen	0,8	Sclerostin	54,64	Estrogen	Sclerostin	MESH:D004967	50964	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Estrogen Modulates Bone_Morphogenetic_Protein-Induced Sclerostin Expression Through the Wnt Signaling Pathway .
18550773	0	Estrogen	0,8	Snail	19,24	Estrogen	Snail	MESH:D004967	6615	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Estrogen regulates Snail and Slug in the down-regulation of E-cadherin and induces metastatic potential of ovarian_cancer cells through estrogen_receptor_alpha .
26804240	0	Estrogen	0,8	SphK1	100,105	Estrogen	SphK1	MESH:D004967	170897(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Estrogen regulates excitatory amino_acid carrier 1 -LRB- EAAC1 -RRB- expression through sphingosine_kinase_1 -LRB- SphK1 -RRB- transacting FGFR-mediated ERK signaling in rat C6 astroglial cells .
9010318	0	Estrogen	0,8	TGF-alpha	22,31	Estrogen	TGF-alpha	MESH:D004967	7039	Chemical	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	Estrogen induction of TGF-alpha is mediated by an estrogen response element composed of two imperfect palindromes .
25534329	0	Estrogen	0,8	TGF-b1	20,26	Estrogen	TGF-b1	MESH:D004967	59086(Tax:10116)	Chemical	Gene	Attenuates|compound|START_ENTITY END_ENTITY|nsubj|Attenuates	Estrogen Attenuates TGF-b1 Induced Elastogenesis in Rat Urethral Smooth Muscle Cells by Inhibiting Smad Response Elements .
25833830	0	Estrogen	48,56	TGFb	8,12	Estrogen	TGFb	MESH:D004967	7040	Chemical	Gene	Response|compound|START_ENTITY Response|compound|END_ENTITY	Loss of TGFb Receptor Type 2 Expression Impairs Estrogen Response and Confers Tamoxifen Resistance .
10449442	0	Estrogen	0,8	TNF	19,22	Estrogen	TNF	MESH:D004967	21926(Tax:10090)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|compound|END_ENTITY	Estrogen decreases TNF gene expression by blocking JNK activity and the resulting production of c-Jun and JunD .
11418693	0	Estrogen	0,8	TNF-alpha	34,43	Estrogen	TNF-alpha	MESH:D004967	21926(Tax:10090)	Chemical	Gene	treatment|compound|START_ENTITY down-regulates|nsubj|treatment down-regulates|dobj|production production|amod|END_ENTITY	Estrogen treatment down-regulates TNF-alpha production and reduces the severity of experimental autoimmune encephalomyelitis in cytokine knockout mice .
11890714	0	Estrogen	0,8	TNF-alpha	48,57	Estrogen	TNF-alpha	MESH:D004967	21926(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Estrogen inhibits systemic T cell expression of TNF-alpha and recruitment of TNF-alpha -LRB- + -RRB- T cells and macrophages into the CNS of mice developing experimental encephalomyelitis .
17936319	0	Estrogen	0,8	TNF-alpha	19,28	Estrogen	TNF-alpha	MESH:D004967	7124	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|END_ENTITY	Estrogen decreases TNF-alpha and oxidized LDL induced apoptosis in endothelial cells .
21543429	0	Estrogen	0,8	TNF-alpha	106,115	Estrogen	TNF-alpha	MESH:D004967	7124	Chemical	Gene	sulfotransferase|compound|START_ENTITY expressed|nsubjpass|sulfotransferase expressed|nmod|END_ENTITY	Estrogen sulfotransferase is expressed in subcutaneous adipose tissue of obese humans in association with TNF-alpha and SOCS3 .
20482834	0	Estrogen	0,8	TRPM8	23,28	Estrogen	TRPM8	MESH:D004967	79054	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Estrogen regulation of TRPM8 expression in breast_cancer cells .
22398379	0	Estrogen	0,8	Th2	20,23	Estrogen	Th2	MESH:D004967	15111(Tax:10090)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|amod|END_ENTITY	Estrogen stimulates Th2 cytokine production and regulates the compartmentalisation of eosinophils during allergen challenge in a mouse model of asthma .
24737445	0	Estrogen	0,8	Tnfaip1	33,40	Estrogen	Tnfaip1	MESH:D004967	21927(Tax:10090)	Chemical	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	Estrogen is a novel regulator of Tnfaip1 in mouse hippocampus .
24905577	0	Estrogen	0,8	Vav1	17,21	Estrogen	Vav1	MESH:D004967	7409	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Estrogen induces Vav1 expression in human breast_cancer cells .
21297881	0	Estrogen	0,8	X-box_binding_protein-1	23,46	Estrogen	X-box binding protein-1	MESH:D004967	7494	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Estrogen regulation of X-box_binding_protein-1 and its role in estrogen induced growth of breast and endometrial_cancer cells .
24504099	0	Estrogen	0,8	a2-Heremans-Schmid-glycoprotein	46,77	Estrogen	a2-Heremans-Schmid-glycoprotein	MESH:D004967	197	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|transcription transcription|nmod|END_ENTITY	Estrogen increases the transcription of human a2-Heremans-Schmid-glycoprotein by an interplay of estrogen_receptor_a and activator_protein-1 .
19159662	0	Estrogen	0,8	activity-regulated_cytoskeleton_associated_protein	20,70	Estrogen	activity-regulated cytoskeleton associated protein	MESH:D004967	23237	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Estrogen stimulates activity-regulated_cytoskeleton_associated_protein -LRB- Arc -RRB- expression via the MAPK - and PI-3K-dependent pathways in SH-SY5Y cells .
9886828	0	Estrogen	0,8	adenosine_deaminase	17,36	Estrogen	adenosine deaminase	MESH:D004967	100	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Estrogen induces adenosine_deaminase gene expression in MCF-7 human breast_cancer cells : role of estrogen_receptor-Sp1 interactions .
1370936	0	Estrogen	0,8	alcohol_dehydrogenase	22,43	Estrogen	alcohol dehydrogenase	MESH:D004967	101804381	Chemical	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	Estrogen induction of alcohol_dehydrogenase in the uropygial gland of mallard_ducks .
20668027	0	Estrogen	0,8	amiloride-binding_protein_1	19,46	Estrogen	amiloride-binding protein 1	MESH:D004967	76507(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	Estrogen regulates amiloride-binding_protein_1 through CCAAT/enhancer-binding protein-beta in mouse uterus during embryo implantation and decidualization .
25961250	0	Estrogen	0,8	amphiregulin	28,40	Estrogen	amphiregulin	MESH:D004967	374	Chemical	Gene	START_ENTITY|acl|signalling signalling|nmod|END_ENTITY	Estrogen signalling through amphiregulin may be implicated in human hepatocellular_carcinoma .
7649107	0	Estrogen	0,8	amphiregulin	37,49	Estrogen	amphiregulin	MESH:D004967	374	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|compound|END_ENTITY	Estrogen and phorbol_esters regulate amphiregulin expression by two separate mechanisms in human breast_cancer cell lines .
14750653	0	Estrogen	0,8	amyloid_precursor_protein	16,41	Estrogen	amyloid precursor protein	MESH:D004967	11820(Tax:10090)	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|END_ENTITY	Estrogen alters amyloid_precursor_protein as well as dendritic and cholinergic markers in a mouse model of Down_syndrome .
15663894	0	Estrogen	0,8	amyloid_precursor_protein	40,65	Estrogen	amyloid precursor protein	MESH:D004967	54226(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|nmod|END_ENTITY	Estrogen stimulates release of secreted amyloid_precursor_protein from primary rat cortical neurons via protein kinase C pathway .
10433226	0	Estrogen	0,8	androgen_receptor	39,56	Estrogen	androgen receptor	MESH:D004967	24208(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Estrogen , but not androgens , regulates androgen_receptor messenger ribonucleic acid expression in the developing male rat forebrain .
24552459	0	Estrogen	0,8	androgen_receptor	44,61	Estrogen	androgen receptor	MESH:D004967	367	Chemical	Gene	beta|compound|START_ENTITY beta|nmod|action action|compound|END_ENTITY	Estrogen receptor beta as a novel target of androgen_receptor action in breast_cancer cell lines .
9931124	0	Estrogen	0,8	angiotensin-converting_enzyme	23,52	Estrogen	angiotensin-converting enzyme	MESH:D004967	24310(Tax:10116)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|mRNA mRNA|amod|END_ENTITY	Estrogen regulation of angiotensin-converting_enzyme mRNA .
8142296	0	Estrogen	0,8	angiotensinogen	40,55	Estrogen	angiotensinogen	MESH:D004967	183	Chemical	Gene	action|compound|START_ENTITY action|nmod|synthesis synthesis|nmod|END_ENTITY	Estrogen action on hepatic synthesis of angiotensinogen and IGF-I : direct and indirect estrogen effects .
15033916	0	Estrogen	0,8	apolipoprotein_E	43,59	Estrogen	apolipoprotein E	MESH:D004967	11816(Tax:10090)	Chemical	Gene	facilitates|nsubj|START_ENTITY facilitates|dobj|extension extension|nmod|END_ENTITY	Estrogen facilitates neurite extension via apolipoprotein_E in cultured adult mouse cortical neurons .
6812967	0	Estrogen	0,8	apolipoprotein_E	56,72	Estrogen	apolipoprotein E	MESH:D004967	348	Chemical	Gene	treatment|compound|START_ENTITY changes|nsubj|treatment changes|dobj|distribution distribution|nmod|END_ENTITY	Estrogen treatment changes the cellular distribution of apolipoprotein_E in the liver .
9407129	0	Estrogen	0,8	apolipoprotein_E	22,38	Estrogen	apolipoprotein E	MESH:D004967	11816(Tax:10090)	Chemical	Gene	up-regulates|compound|START_ENTITY END_ENTITY|nsubj|up-regulates	Estrogen up-regulates apolipoprotein_E -LRB- ApoE -RRB- gene expression by increasing ApoE mRNA in the translating pool via the estrogen_receptor_alpha-mediated pathway .
11588579	0	Estrogen	0,8	bcl-x	19,24	Estrogen	bcl-x	MESH:D004967	24888(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Estrogen regulates bcl-x expression in rat hippocampus .
7476964	0	Estrogen	0,8	beta_3	105,111	Estrogen	beta 3	MESH:D004967	1934	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|precursors precursors|nmod|stabilization stabilization|nmod|mRNA mRNA|amod|END_ENTITY	Estrogen enhances alpha v beta_3 integrin expression by avian osteoclast precursors via stabilization of beta_3 integrin mRNA .
7476964	0	Estrogen	0,8	beta_3	26,32	Estrogen	beta 3	MESH:D004967	1934	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Estrogen enhances alpha v beta_3 integrin expression by avian osteoclast precursors via stabilization of beta_3 integrin mRNA .
12829444	0	Estrogen	0,8	biglycan	19,27	Estrogen	biglycan	MESH:D004967	25181(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|compound|END_ENTITY	Estrogen decreases biglycan mRNA expression in resistance blood vessels .
11592117	0	Estrogen	0,8	brain-derived_neurotrophic_factor	20,53	Estrogen	brain-derived neurotrophic factor	MESH:D004967	12064(Tax:10090)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Estrogen stimulates brain-derived_neurotrophic_factor expression in embryonic mouse midbrain neurons through a membrane-mediated and calcium-dependent mechanism .
11860494	0	Estrogen	0,8	brain-derived_neurotrophic_factor	43,76	Estrogen	brain-derived neurotrophic factor	MESH:D004967	627	Chemical	Gene	interact|nsubj|START_ENTITY interact|xcomp|regulate regulate|dobj|mRNA mRNA|amod|END_ENTITY	Estrogen and exercise interact to regulate brain-derived_neurotrophic_factor mRNA and protein expression in the hippocampus .
11923430	0	Estrogen	0,8	brain-derived_neurotrophic_factor	38,71	Estrogen	brain-derived neurotrophic factor	MESH:D004967	24225(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|development development|nmod|mRNA mRNA|amod|END_ENTITY	Estrogen regulates the development of brain-derived_neurotrophic_factor mRNA and protein in the rat hippocampus .
12960034	0	Estrogen	0,8	brain-derived_neurotrophic_factor	42,75	Estrogen	brain-derived neurotrophic factor	MESH:D004967	627	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|transport transport|nmod|END_ENTITY	Estrogen enhances retrograde transport of brain-derived_neurotrophic_factor in the rodent forebrain .
16020928	0	Estrogen	0,8	brain-derived_neurotrophic_factor	38,71	Estrogen	brain-derived neurotrophic factor	MESH:D004967	24225(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Estrogen increases nociception-evoked brain-derived_neurotrophic_factor gene expression in the female rat .
25662808	0	Estrogen	0,8	brain-derived_neurotrophic_factor	36,69	Estrogen	brain-derived neurotrophic factor	MESH:D004967	12064(Tax:10090)	Chemical	Gene	induced|compound|START_ENTITY changes|nsubj|induced changes|nmod|END_ENTITY	Estrogen induced changes in uterine brain-derived_neurotrophic_factor and its receptors .
11124587	0	Estrogen	0,8	c-Fos	42,47	Estrogen	c-Fos	MESH:D004967	314322(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Estrogen increases angiotensin_II-induced c-Fos expression in the vasopressinergic neurons of the paraventricular nucleus in the female rat .
16545785	0	Estrogen	0,8	c-Fos	16,21	Estrogen	c-Fos	MESH:D004967	314322(Tax:10116)	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|response response|amod|END_ENTITY	Estrogen alters c-Fos response to immobilization stress in the brain of ovariectomized rats .
21358146	0	Estrogen	0,8	c-Fos	19,24	Estrogen	c-Fos	MESH:D004967	314322(Tax:10116)	Chemical	Gene	Increases|compound|START_ENTITY END_ENTITY|nsubj|Increases	Estrogen Increases c-Fos expression in the paraventricular nucleus along with its anorexic effect in developing rats .
9662718	0	Estrogen	0,8	c-Fos	41,46	Estrogen	c-Fos	MESH:D004967	314322(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|amod|END_ENTITY	Estrogen reduces cholecystokinin-induced c-Fos expression in the rat brain .
15607540	0	Estrogen	0,8	c-Myc	138,143	Estrogen	c-Myc	MESH:D004967	4609	Chemical	Gene	stimulate|nsubj|START_ENTITY stimulate|nmod|regulation regulation|nmod|END_ENTITY	Estrogen and insulin/IGF -1 cooperatively stimulate cell cycle progression in MCF-7 breast_cancer cells through differential regulation of c-Myc and cyclin_D1 .
19564413	0	Estrogen	0,8	c-Myc	60,65	Estrogen	c-Myc	MESH:D004967	4609	Chemical	Gene	regulation|compound|START_ENTITY requires|nsubj|regulation requires|xcomp|END_ENTITY	Estrogen regulation of cyclin_E2 requires cyclin_D1 but not c-Myc .
8685038	0	Estrogen	0,8	c-erbB-2	37,45	Estrogen	c-erbB-2	MESH:D004967	2064	Chemical	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Estrogen and progesterone receptors , c-erbB-2 , p53 , and Bcl-2 in thirty-three invasive micropapillary_breast_carcinomas .
12051724	0	Estrogen	0,8	c-fos	23,28	Estrogen	c-fos	MESH:D004967	2353	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Estrogen regulation of c-fos gene expression through phosphatidylinositol-3-kinase-dependent activation of serum_response_factor in MCF-7 breast_cancer cells .
1902094	0	Estrogen	0,8	c-fos	17,22	Estrogen	c-fos	MESH:D004967	314322(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Estrogen induces c-fos expression specifically in the luminal and glandular epithelia of adult rat uterus .
3141795	0	Estrogen	0,8	c-fos	23,28	Estrogen	c-fos	MESH:D004967	314322(Tax:10116)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Estrogen regulation of c-fos messenger ribonucleic acid .
3173352	0	Estrogen	0,8	c-fos	31,36	Estrogen	c-fos	MESH:D004967	314322(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|protooncogenes protooncogenes|amod|END_ENTITY	Estrogen induces expression of c-fos and c-myc protooncogenes in rat uterus .
8701784	0	Estrogen	0,8	c-fos	31,36	Estrogen	c-fos	MESH:D004967	2353	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Estrogen induces expression of c-fos and c-jun via activation of protein_kinase_C in an endometrial_cancer cell line and fibroblasts derived from human uterine endometrium .
8788311	0	Estrogen	0,8	c-fos	35,40	Estrogen	c-fos	MESH:D004967	2353	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|genes genes|amod|END_ENTITY	Estrogen induces the expression of c-fos and c-jun genes in fibroblasts derived from human uterine endometrium .
9811905	0	Estrogen	0,8	c-fos	39,44	Estrogen	c-fos	MESH:D004967	314322(Tax:10116)	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|expression expression|compound|END_ENTITY	Estrogen alters behavior and forebrain c-fos expression in ovariectomized rats subjected to the forced swim test .
21835891	0	Estrogen	0,8	c-myc	17,22	Estrogen	c-myc	MESH:D004967	4609	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Estrogen induces c-myc gene expression via an upstream enhancer activated by the estrogen_receptor and the AP-1 transcription factor .
16611827	0	Estrogen	0,8	cAMP_response_element-binding_protein	51,88	Estrogen	cAMP response element-binding protein	MESH:D004967	12912(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Estrogen induces estrogen receptor alpha-dependent cAMP_response_element-binding_protein phosphorylation via mitogen activated protein kinase pathway in basal forebrain cholinergic neurons in vivo .
8612562	0	Estrogen	0,8	cAMP_response_element_binding_protein	52,89	Estrogen	cAMP response element binding protein	MESH:D004967	81646(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Estrogen rapidly induces the phosphorylation of the cAMP_response_element_binding_protein in rat brain .
1537319	0	Estrogen	0,8	calbindin-D28k	18,32	Estrogen	calbindin-D28k	MESH:D004967	12307(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Estrogen inhibits calbindin-D28k expression in mouse uterus .
26709452	0	Estrogen	0,8	carbonic_anhydrase_II	50,71	Estrogen	carbonic anhydrase II	MESH:D004967	54231(Tax:10116)	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	Estrogen and progesterone differentially regulate carbonic_anhydrase_II , III , IX , XII , and XIII in ovariectomized rat uteri .
18451179	0	Estrogen	0,8	carbonic_anhydrase_XII	32,54	Estrogen	carbonic anhydrase XII	MESH:D004967	76459(Tax:10090)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Estrogen receptor regulation of carbonic_anhydrase_XII through a distal enhancer in breast_cancer .
12003841	0	Estrogen	0,8	caveolin-3	62,72	Estrogen	caveolin-3	MESH:D004967	29161(Tax:10116)	Chemical	Gene	modulation|compound|START_ENTITY modulation|nmod|END_ENTITY	Estrogen modulation of eNOS activity and its association with caveolin-3 and calmodulin in rat hearts .
25403608	0	Estrogen	0,8	chymase	28,35	Estrogen	chymase	MESH:D004967	29265(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|compound|END_ENTITY	Estrogen inhibits mast cell chymase release to prevent pressure overload-induced adverse_cardiac_remodeling .
1168985	0	Estrogen	0,8	conjugase	24,33	Estrogen	conjugase	MESH:D004967	25455(Tax:10116)	Chemical	Gene	stimulation|compound|START_ENTITY stimulation|nmod|activity activity|amod|END_ENTITY	Estrogen stimulation of conjugase activity in the uterus of ovariectomized rats .
11075820	0	Estrogen	0,8	constitutive_active_receptor	56,84	Estrogen	constitutive active receptor	MESH:D004967	12355(Tax:10090)	Chemical	Gene	activation|compound|START_ENTITY activation|appos|END_ENTITY	Estrogen activation of the nuclear orphan receptor CAR -LRB- constitutive_active_receptor -RRB- in induction of the mouse Cyp2b10 gene .
2284002	0	Estrogen	0,8	creatine_kinase-B	23,40	Estrogen	creatine kinase-B	MESH:D004967	24264(Tax:10116)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Estrogen regulation of creatine_kinase-B in the rat uterus .
10500157	0	Estrogen	0,8	cyclin_D1	26,35	Estrogen	cyclin D1	MESH:D004967	595	Chemical	Gene	induction|compound|START_ENTITY induction|nmod|promoter promoter|amod|END_ENTITY	Estrogen induction of the cyclin_D1 promoter : involvement of a cAMP response-like element .
11410592	0	Estrogen	0,8	cyclin_D1	23,32	Estrogen	cyclin D1	MESH:D004967	595	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Estrogen regulation of cyclin_D1 gene expression in ZR-75 breast_cancer cells involves multiple enhancer elements .
19564413	0	Estrogen	0,8	cyclin_D1	42,51	Estrogen	cyclin D1	MESH:D004967	595	Chemical	Gene	regulation|compound|START_ENTITY requires|nsubj|regulation requires|xcomp|c-Myc c-Myc|dep|END_ENTITY	Estrogen regulation of cyclin_E2 requires cyclin_D1 but not c-Myc .
19564413	0	Estrogen	0,8	cyclin_E2	23,32	Estrogen	cyclin E2	MESH:D004967	9134	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Estrogen regulation of cyclin_E2 requires cyclin_D1 but not c-Myc .
15136101	0	Estrogen	0,8	cyclooxygenase-2	22,38	Estrogen	cyclooxygenase-2	MESH:D004967	5743	Chemical	Gene	up-regulates|nsubj|START_ENTITY up-regulates|xcomp|END_ENTITY	Estrogen up-regulates cyclooxygenase-2 via estrogen receptor in human uterine microvascular endothelial cells .
15937092	0	Estrogen	0,8	cyclooxygenase-2	86,102	Estrogen	cyclooxygenase-2	MESH:D004967	29527(Tax:10116)	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|advcl|enhancing enhancing|dobj|function function|amod|END_ENTITY	Estrogen potentiates vasopressin-induced contraction of female rat aorta by enhancing cyclooxygenase-2 and thromboxane function .
18310519	0	Estrogen	0,8	cyclooxygenase-2	92,108	Estrogen	cyclooxygenase-2	MESH:D004967	29527(Tax:10116)	Chemical	Gene	potentiates|compound|START_ENTITY prostanoid|nsubj|potentiates prostanoid|nmod|upregulation upregulation|nmod|expression expression|amod|END_ENTITY	Estrogen potentiates constrictor prostanoid function in female rat aorta by upregulation of cyclooxygenase-2 and thromboxane pathway expression .
19318151	0	Estrogen	0,8	cyclooxygenase-2	32,48	Estrogen	cyclooxygenase-2	MESH:D004967	5743	Chemical	Gene	receptor-beta|compound|START_ENTITY mediates|nsubj|receptor-beta mediates|dobj|expression expression|amod|END_ENTITY	Estrogen receptor-beta mediates cyclooxygenase-2 expression and vascular prostanoid levels in human placental villous endothelial cells .
22542504	0	Estrogen	0,8	cyclooxygenase-2	65,81	Estrogen	cyclooxygenase-2	MESH:D004967	5743	Chemical	Gene	receptor|nsubj|START_ENTITY receptor|dobj|attenuation attenuation|nmod|END_ENTITY	Estrogen receptor beta dependent attenuation of cytokine-induced cyclooxygenase-2 by androgens in human brain vascular smooth muscle cells and rat mesenteric arteries .
14764809	0	Estrogen	0,8	cystatin_C	18,28	Estrogen	cystatin C	MESH:D004967	574313(Tax:9544)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Estrogen enhances cystatin_C expression in the macaque vagina .
1373180	0	Estrogen	0,8	cytochrome_c_oxidase_subunit_III	22,54	Estrogen	cytochrome c oxidase subunit III	MESH:D004967	26204(Tax:10116)	Chemical	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	Estrogen induction of cytochrome_c_oxidase_subunit_III in rat hippocampus .
12963642	0	Estrogen	0,8	dimethylarginine_dimethylaminohydrolase	20,59	Estrogen	dimethylarginine dimethylaminohydrolase	MESH:D004967	23576	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|amod|END_ENTITY	Estrogen stimulates dimethylarginine_dimethylaminohydrolase activity and the metabolism of asymmetric dimethylarginine .
12003841	0	Estrogen	0,8	eNOS	23,27	Estrogen	eNOS	MESH:D004967	24600(Tax:10116)	Chemical	Gene	modulation|compound|START_ENTITY modulation|nmod|activity activity|amod|END_ENTITY	Estrogen modulation of eNOS activity and its association with caveolin-3 and calmodulin in rat hearts .
11044445	0	Estrogen	0,8	endothelial_nitric-oxide_synthase	49,82	Estrogen	endothelial nitric-oxide synthase	MESH:D004967	4846	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|nmod|END_ENTITY	Estrogen induces the Akt-dependent activation of endothelial_nitric-oxide_synthase in vascular endothelial cells .
10671543	0	Estrogen	0,8	endothelial_nitric_oxide_synthase	53,86	Estrogen	endothelial nitric oxide synthase	MESH:D004967	4846	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|xcomp|END_ENTITY	Estrogen stimulates heat shock protein 90 binding to endothelial_nitric_oxide_synthase in human vascular endothelial cells .
11589505	0	Estrogen	0,8	endothelial_nitric_oxide_synthase	37,70	Estrogen	endothelial nitric oxide synthase	MESH:D004967	4846	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|dobj|destabilization destabilization|nmod|mRNA mRNA|amod|END_ENTITY	Estrogen prevents destabilization of endothelial_nitric_oxide_synthase mRNA induced by tumor_necrosis_factor_alpha through estrogen receptor mediated system .
12053012	0	Estrogen	0,8	endothelial_nitric_oxide_synthase	19,52	Estrogen	endothelial nitric oxide synthase	MESH:D004967	24600(Tax:10116)	Chemical	Gene	increases|nummod|START_ENTITY END_ENTITY|nmod:npmod|increases	Estrogen increases endothelial_nitric_oxide_synthase via estrogen receptors in rat cerebral blood vessels : effect preserved after concurrent treatment with medroxyprogesterone_acetate or progesterone .
25553642	0	Estrogen	0,8	endothelial_nitric_oxide_synthase	79,112	Estrogen	endothelial nitric oxide synthase	MESH:D004967	18127(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|nmod|expression expression|compound|END_ENTITY	Estrogen increases the severity of anaphylaxis in female mice through enhanced endothelial_nitric_oxide_synthase expression and nitric_oxide production .
8831924	0	Estrogen	0,8	endothelin-1	18,30	Estrogen	endothelin-1	MESH:D004967	24323(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Estrogen inhibits endothelin-1 production and c-fos gene expression in rat aorta .
9790900	0	Estrogen	0,8	endothelin-1	20,32	Estrogen	endothelin-1	MESH:D004967	281137(Tax:9913)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|production production|amod|END_ENTITY	Estrogen attenuates endothelin-1 production by bovine endothelial cells via estrogen receptor .
2342484	0	Estrogen	0,8	epidermal_growth_factor	36,59	Estrogen	epidermal growth factor	MESH:D004967	13645(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|synthesis synthesis|nmod|END_ENTITY	Estrogen regulates the synthesis of epidermal_growth_factor in mouse uterine epithelial cells .
7595145	0	Estrogen	0,8	epidermal_growth_factor	34,57	Estrogen	epidermal growth factor	MESH:D004967	25313(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|release release|nmod|END_ENTITY	Estrogen increases the release of epidermal_growth_factor from individual pituitary cells in female rats .
1672626	0	Estrogen	0,8	epidermal_growth_factor_receptor	19,51	Estrogen	epidermal growth factor receptor	MESH:D004967	24329(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|ploidy ploidy|compound|END_ENTITY	Estrogen receptor , epidermal_growth_factor_receptor and cellular ploidy in elutriated subpopulations of hepatocytes during liver_tumor promotion by 17 alpha-ethinylestradiol in rats .
3398852	0	Estrogen	0,8	epidermal_growth_factor_receptor	23,55	Estrogen	epidermal growth factor receptor	MESH:D004967	1956	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Estrogen regulation of epidermal_growth_factor_receptor messenger ribonucleic acid .
21624334	0	Estrogen	0,8	epithelial_sodium_channel	50,75	Estrogen	epithelial sodium channel	MESH:D004967	20276(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Estrogen regulates the expression and activity of epithelial_sodium_channel in mouse osteoblasts .
12960079	0	Estrogen	0,8	estrogen-related_receptor_alpha	20,51	Estrogen	estrogen-related receptor alpha	MESH:D004967	2101	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Estrogen stimulates estrogen-related_receptor_alpha gene expression through conserved hormone response elements .
18174157	0	Estrogen	0,8	estrogen-related_receptor_alpha	17,48	Estrogen	estrogen-related receptor alpha	MESH:D004967	2101	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Estrogen induces estrogen-related_receptor_alpha gene expression and chromatin structural changes in estrogen_receptor -LRB- ER -RRB- - positive and ER-negative breast_cancer cells .
11014249	0	Estrogen	0,8	estrogen_receptor	52,69	Estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	agonist|nsubj|START_ENTITY agonist|dobj|action action|nmod|END_ENTITY	Estrogen agonist and antagonist action on the human estrogen_receptor in Drosophila .
1472945	0	Estrogen	0,8	estrogen_receptor	33,50	Estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Estrogen dependent regulation of estrogen_receptor gene expression in normal mammary gland and its relationship to estrogenic sensitivity .
15585566	0	Estrogen	0,8	estrogen_receptor	23,40	Estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	modulators|amod|START_ENTITY modulators|compound|END_ENTITY	Estrogen and selective estrogen_receptor modulators exert neuroprotective effects and stimulate the expression of selective Alzheimer 's _ disease indicator-1 , a recently discovered antiapoptotic gene , in human neuroblast long-term cell cultures .
18473908	0	Estrogen	0,8	estrogen_receptor	64,81	Estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	regulation|compound|START_ENTITY regulation|dep|involvement involvement|nmod|isoforms isoforms|compound|END_ENTITY	Estrogen regulation of adipose tissue functions : involvement of estrogen_receptor isoforms .
21615412	0	Estrogen	0,8	estrogen_receptor	86,103	Estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|cells cells|acl|displaying displaying|dobj|b b|compound|END_ENTITY	Estrogen regulates DNA synthesis in human gingival epithelial cells displaying strong estrogen_receptor b immunoreactivity .
21835891	0	Estrogen	0,8	estrogen_receptor	81,98	Estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|enhancer enhancer|acl|activated activated|nmod|END_ENTITY	Estrogen induces c-myc gene expression via an upstream enhancer activated by the estrogen_receptor and the AP-1 transcription factor .
22119000	0	Estrogen	0,8	estrogen_receptor	48,65	Estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|inhibition inhibition|compound|END_ENTITY	Estrogen protects against amyloid-b toxicity by estrogen_receptor a-mediated inhibition of Daxx translocation .
2458728	0	Estrogen	0,8	estrogen_receptor	29,46	Estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	induced|nsubj|START_ENTITY induced|dobj|increase increase|nmod|RNA RNA|compound|END_ENTITY	Estrogen induced increase of estrogen_receptor RNA in human breast_cancer cells .
3347042	0	Estrogen	0,8	estrogen_receptor	43,60	Estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	interaction|compound|START_ENTITY interaction|nmod|END_ENTITY	Estrogen and antiestrogen interaction with estrogen_receptor of MCF-7 cells -- relationship between processing and estrogenicity .
7720671	0	Estrogen	0,8	estrogen_receptor	80,97	Estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	tissue|compound|START_ENTITY determines|nsubj|tissue determines|dobj|utilization utilization|nmod|gene gene|compound|END_ENTITY	Estrogen target tissue determines alternative promoter utilization of the human estrogen_receptor gene in osteoblasts and tumor cell lines .
8835380	0	Estrogen	0,8	estrogen_receptor	30,47	Estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	Estrogen enhances endometrial estrogen_receptor gene expression by a posttranscriptional mechanism in the ovariectomized ewe .
8904314	0	Estrogen	0,8	estrogen_receptor	104,121	Estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	response|compound|START_ENTITY transfected|nsubj|response transfected|nmod|gene gene|compound|END_ENTITY	Estrogen response in the hFOB_1 .19 human fetal osteoblastic cell line stably transfected with the human estrogen_receptor gene .
9405735	0	Estrogen	0,8	estrogen_receptor	117,134	Estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	effects|nsubj|START_ENTITY effects|nmod|expression expression|nmod|line line|nmod|levels levels|nmod|END_ENTITY	Estrogen effects on insulin-like growth factor gene expression in a human osteoblastic cell line with high levels of estrogen_receptor .
9883989	0	Estrogen	0,8	estrogen_receptor	30,47	Estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	causes|nsubj|START_ENTITY causes|dobj|death death|nmod|cells cells|amod|END_ENTITY	Estrogen causes cell death of estrogen_receptor stably transfected cells via apoptosis .
25663821	0	Estrogen	0,8	estrogen_receptor-a	103,122	Estrogen	estrogen receptor-a	MESH:D004967	2099	Chemical	Gene	mediated|nsubj|START_ENTITY mediated|nmod|signaling signaling|amod|END_ENTITY	Estrogen mediated expression of nucleophosmin_1 in human endometrial_carcinoma clinical stages through estrogen_receptor-a signaling .
11719281	0	Estrogen	0,8	estrogen_receptor-alpha	57,80	Estrogen	estrogen receptor-alpha	MESH:D004967	2099	Chemical	Gene	binding|compound|START_ENTITY induces|nsubj|binding induces|nmod|conformation conformation|amod|END_ENTITY	Estrogen response element binding induces alterations in estrogen_receptor-alpha conformation as revealed by susceptibility to partial proteolysis .
15296482	0	Estrogen	0,8	estrogen_receptor-alpha	61,84	Estrogen	estrogen receptor-alpha	MESH:D004967	13982(Tax:10090)	Chemical	Gene	START_ENTITY|acl|increases_coagulation_factor_V increases_coagulation_factor_V|dobj|levels levels|nmod|END_ENTITY	Estrogen increases_coagulation_factor_V mRNA levels via both estrogen_receptor-alpha and - beta in murine bone marrow/bone .
15984004	0	Estrogen	0,8	estrogen_receptor-alpha	62,85	Estrogen	estrogen receptor-alpha	MESH:D004967	2099	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Estrogen regulation of cell proliferation and distribution of estrogen_receptor-alpha in the brains of adult female prairie and meadow voles .
17505058	0	Estrogen	0,8	estrogen_receptor-alpha	46,69	Estrogen	estrogen receptor-alpha	MESH:D004967	2099	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|appos|coactivator coactivator|amod|END_ENTITY	Estrogen induces expression of BCAS3 , a novel estrogen_receptor-alpha coactivator , through proline - , glutamic_acid - , and leucine-rich protein-1 -LRB- PELP1 -RRB- .
17617929	0	Estrogen	0,8	estrogen_receptor-alpha	65,88	Estrogen	estrogen receptor-alpha	MESH:D004967	2099	Chemical	Gene	START_ENTITY|dobj|receptor-beta receptor-beta|dep|influence influence|nmod|breast_cancer breast_cancer|amod|END_ENTITY	Estrogen receptor-beta : why may it influence clinical outcome in estrogen_receptor-alpha positive breast_cancer ?
19331827	0	Estrogen	0,8	estrogen_receptor-alpha	135,158	Estrogen	estrogen receptor-alpha	MESH:D004967	2099	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|interaction interaction|nmod|END_ENTITY	Estrogen inhibits RANKL-stimulated osteoclastic differentiation of human monocytes through estrogen and RANKL-regulated interaction of estrogen_receptor-alpha with BCAR1 and Traf6 .
26592768	0	Estrogen	0,8	estrogen_receptor_a	49,68	Estrogen	estrogen receptor a	MESH:D004967	2099	Chemical	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Estrogen induced the expression of ADAM9 through estrogen_receptor_a but not estrogen receptor b in cultured human neuronal cells .
11306182	0	Estrogen	0,8	estrogen_receptor_alpha	92,115	Estrogen	estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	sequence|compound|START_ENTITY impacts|nsubj|sequence impacts|dobj|activity activity|nmod|END_ENTITY	Estrogen response element sequence impacts the conformation and transcriptional activity of estrogen_receptor_alpha .
11455579	0	Estrogen	0,8	estrogen_receptor_alpha	19,42	Estrogen	estrogen receptor alpha	MESH:D004967	13982(Tax:10090)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|compound|END_ENTITY	Estrogen modulates estrogen_receptor_alpha and beta expression , osteogenic activity , and apoptosis in mesenchymal stem cells -LRB- MSCs -RRB- of osteoporotic mice .
11507058	0	Estrogen	0,8	estrogen_receptor_alpha	81,104	Estrogen	estrogen receptor alpha	MESH:D004967	13982(Tax:10090)	Chemical	Gene	imprinting|compound|START_ENTITY mediated|nsubjpass|imprinting mediated|nmod|END_ENTITY	Estrogen imprinting of the developing prostate gland is mediated through stromal estrogen_receptor_alpha : studies with alphaERKO and betaERKO mice .
12488349	0	Estrogen	0,8	estrogen_receptor_alpha	54,77	Estrogen	estrogen receptor alpha	MESH:D004967	13982(Tax:10090)	Chemical	Gene	activity|compound|START_ENTITY activity|nmod|mice mice|nmod|END_ENTITY	Estrogen increases locomotor activity in mice through estrogen_receptor_alpha : specificity for the type of activity .
14592957	0	Estrogen	0,8	estrogen_receptor_alpha	96,119	Estrogen	estrogen receptor alpha	MESH:D004967	13982(Tax:10090)	Chemical	Gene	regulation|compound|START_ENTITY mediated|nsubjpass|regulation mediated|nmod|END_ENTITY	Estrogen regulation of neurokinin_B gene expression in the mouse arcuate nucleus is mediated by estrogen_receptor_alpha .
14647449	0	Estrogen	0,8	estrogen_receptor_alpha	126,149	Estrogen	estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	regulation|compound|START_ENTITY breast_cancer|nsubj|regulation breast_cancer|nmod|interaction interaction|nmod|proteins proteins|compound|END_ENTITY	Estrogen regulation of vascular_endothelial_growth_factor gene expression in ZR-75 breast_cancer cells through interaction of estrogen_receptor_alpha and SP proteins .
15070958	0	Estrogen	0,8	estrogen_receptor_alpha	119,142	Estrogen	estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	controls|nsubj|START_ENTITY controls|advcl|up-regulating up-regulating|nmod|END_ENTITY	Estrogen controls lipolysis by up-regulating alpha2A-adrenergic receptors directly in human adipose tissue through the estrogen_receptor_alpha .
15285303	0	Estrogen	0,8	estrogen_receptor_alpha	87,110	Estrogen	estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	beta|compound|START_ENTITY expression|compound|beta correlated|nsubjpass|expression correlated|nmod|END_ENTITY	Estrogen receptor beta -LRB- ERbeta -RRB- expression in breast_carcinomas is not correlated with estrogen_receptor_alpha -LRB- ERalpha -RRB- and prognosis : the Greek experience .
15541729	0	Estrogen	0,8	estrogen_receptor_alpha	54,77	Estrogen	estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|proteins proteins|compound|END_ENTITY	Estrogen regulation of trefoil factor 1 expression by estrogen_receptor_alpha and Sp proteins .
16343790	0	Estrogen	0,8	estrogen_receptor_alpha	57,80	Estrogen	estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|role role|nmod|beta beta|compound|END_ENTITY	Estrogen activates rapid signaling in the brain : role of estrogen_receptor_alpha and estrogen receptor beta in neurons and glia .
16939403	0	Estrogen	0,8	estrogen_receptor_alpha	64,87	Estrogen	estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	polymorphisms|amod|START_ENTITY polymorphisms|nmod|interaction interaction|nmod|END_ENTITY	Estrogen receptor beta -LRB- ESR2 -RRB- polymorphisms in interaction with estrogen_receptor_alpha -LRB- ESR1 -RRB- and insulin-like_growth_factor_I -LRB- IGF1 -RRB- variants influence the risk of fracture in postmenopausal women .
17440111	0	Estrogen	0,8	estrogen_receptor_alpha	68,91	Estrogen	estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	beta2|compound|START_ENTITY regulates|nsubj|beta2 regulates|dobj|transactivation transactivation|nmod|END_ENTITY	Estrogen receptor beta2 negatively regulates the transactivation of estrogen_receptor_alpha in human breast_cancer cells .
17656465	0	Estrogen	0,8	estrogen_receptor_alpha	49,72	Estrogen	estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|complexes complexes|compound|END_ENTITY	Estrogen regulates KiSS1 gene expression through estrogen_receptor_alpha and SP protein complexes .
17803905	0	Estrogen	0,8	estrogen_receptor_alpha	32,55	Estrogen	estrogen receptor alpha	MESH:D004967	13982(Tax:10090)	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|dobj|bone_loss bone_loss|nmod|END_ENTITY	Estrogen prevents bone_loss via estrogen_receptor_alpha and induction of Fas_ligand in osteoclasts .
18455292	0	Estrogen	0,8	estrogen_receptor_alpha	95,118	Estrogen	estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	modulator|nsubj|START_ENTITY modulator|xcomp|protection protection|nmod|death death|nmod|END_ENTITY	Estrogen and the selective estrogen receptor modulator -LRB- SERM -RRB- protection against cell death in estrogen_receptor_alpha and beta expressing U2OS cells .
19084502	0	Estrogen	0,8	estrogen_receptor_alpha	30,53	Estrogen	estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	Estrogen and hypoxia regulate estrogen_receptor_alpha in a synergistic manner .
19398483	0	Estrogen	0,8	estrogen_receptor_alpha	109,132	Estrogen	estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	regulation|compound|START_ENTITY regulation|dep|role role|nmod|END_ENTITY	Estrogen regulation of vascular_endothelial_growth_factor in breast_cancer in vitro and in vivo : the role of estrogen_receptor_alpha and c-Myc .
19668239	0	Estrogen	0,8	estrogen_receptor_alpha	106,129	Estrogen	estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	treatment|compound|START_ENTITY decreases|nsubj|treatment decreases|nmod|END_ENTITY	Estrogen treatment decreases matrix_metalloproteinase _ -LRB- MMP -RRB- -9 in autoimmune_demyelinating_disease through estrogen_receptor_alpha -LRB- ERalpha -RRB- .
19703124	0	Estrogen	0,8	estrogen_receptor_alpha	60,83	Estrogen	estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	beta|compound|START_ENTITY beta|dep|marker marker|nmod|breast_cancer breast_cancer|compound|END_ENTITY	Estrogen receptor beta -- an independent prognostic marker in estrogen_receptor_alpha and progesterone_receptor-positive breast_cancer ?
20043825	0	Estrogen	0,8	estrogen_receptor_alpha	35,58	Estrogen	estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	modulate|nsubj|START_ENTITY modulate|dobj|expression expression|compound|END_ENTITY	Estrogen and inflammation modulate estrogen_receptor_alpha expression in specific tissues of the temporomandibular_joint .
23451233	0	Estrogen	0,8	estrogen_receptor_alpha	70,93	Estrogen	estrogen receptor alpha	MESH:D004967	13982(Tax:10090)	Chemical	Gene	signalling|amod|START_ENTITY signalling|dep|targeting targeting|dobj|action action|compound|END_ENTITY	Estrogen signalling and the metabolic_syndrome : targeting the hepatic estrogen_receptor_alpha action .
2334684	0	Estrogen	0,8	gamma-fibrinogen	38,54	Estrogen	gamma-fibrinogen	MESH:D004967	380331(Tax:8355)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Estrogen regulation of Xenopus_laevis gamma-fibrinogen gene expression .
15063011	0	Estrogen	0,8	ghrelin	19,26	Estrogen	ghrelin	MESH:D004967	59301(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|compound|END_ENTITY	Estrogen modulates ghrelin expression in the female rat stomach .
10537130	0	Estrogen	0,8	gonadotropin-releasing_hormone	29,59	Estrogen	gonadotropin-releasing hormone	MESH:D004967	25194(Tax:10116)	Chemical	Gene	respresses|nsubj|START_ENTITY respresses|dobj|gene gene|amod|END_ENTITY	Estrogen directly respresses gonadotropin-releasing_hormone -LRB- GnRH -RRB- gene expression in estrogen receptor-alpha -LRB- ERalpha -RRB- - and ERbeta-expressing GT1-7 GnRH neurons .
6413811	0	Estrogen	0,8	gonadotropin-releasing_hormone	70,100	Estrogen	gonadotropin-releasing hormone	MESH:D004967	2796	Chemical	Gene	dependence|compound|START_ENTITY dependence|acl|END_ENTITY	Estrogen dependence of the periovulatory plasma prolactin response to gonadotropin-releasing_hormone in normal women .
8045961	0	Estrogen	0,8	gonadotropin-releasing_hormone	41,71	Estrogen	gonadotropin-releasing hormone	MESH:D004967	2796	Chemical	Gene	replacement|compound|START_ENTITY potentiate|nsubj|replacement potentiate|dobj|suppression suppression|amod|END_ENTITY	Estrogen replacement does not potentiate gonadotropin-releasing_hormone agonist-induced androgen suppression in treatment of hirsutism .
11095449	0	Estrogen	0,8	growth_hormone	27,41	Estrogen	growth hormone	MESH:D004967	2688	Chemical	Gene	effect|compound|START_ENTITY effect|nmod|test test|amod|END_ENTITY	Estrogen priming effect on growth_hormone -LRB- GH -RRB- provocative test : a useful tool for the diagnosis of GH_deficiency .
12944101	0	Estrogen	0,8	growth_hormone	48,62	Estrogen	growth hormone	MESH:D004967	2688	Chemical	Gene	agonists/antagonists|compound|START_ENTITY END_ENTITY|nsubj|agonists/antagonists	Estrogen agonists/antagonists may down-regulate growth_hormone signaling in hepatocytes -- an explanation for their impact on IGF-I , IGFBP-1 , and lipoprotein -LRB- a -RRB- .
15466938	0	Estrogen	0,8	growth_hormone	23,37	Estrogen	growth hormone	MESH:D004967	2688	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|action action|amod|END_ENTITY	Estrogen regulation of growth_hormone action .
19145065	0	Estrogen	0,8	growth_hormone	61,75	Estrogen	growth hormone	MESH:D004967	81668(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY involved|nsubjpass|receptors involved|nmod|induction induction|nmod|END_ENTITY	Estrogen receptors are involved in xenoestrogen induction of growth_hormone in the rat pituitary gland .
1915059	0	Estrogen	0,8	growth_hormone	22,36	Estrogen	growth hormone	MESH:D004967	81668(Tax:10116)	Chemical	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	Estrogen induction of growth_hormone in the thyroidectomized rat .
6825920	0	Estrogen	0,8	growth_hormone	48,62	Estrogen	growth hormone	MESH:D004967	14599(Tax:10090)	Chemical	Gene	development|compound|START_ENTITY development|nmod|absence absence|nmod|END_ENTITY	Estrogen receptor development in the absence of growth_hormone and prolactin : studies in dwarf mice .
9390018	0	Estrogen	0,8	growth_hormone	18,32	Estrogen	growth hormone	MESH:D004967	81668(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Estrogen enhances growth_hormone receptor expression and growth_hormone action in rat_osteosarcoma cells and human osteoblast-like cells .
20663978	0	Estrogen	0,8	hMLH1	59,64	Estrogen	hMLH1	MESH:D004967	4292	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|nmod|END_ENTITY	Estrogen stimulates the expression of mismatch repair gene hMLH1 in colonic epithelial cells .
15081317	0	Estrogen	0,8	heat_shock_protein	27,45	Estrogen	heat shock protein	MESH:D004967	290549(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Estrogen and regulation of heat_shock_protein expression in female cardiomyocytes : cross-talk with NF kappa B signaling .
11451387	0	Estrogen	0,8	hepatic_lipase	19,33	Estrogen	hepatic lipase	MESH:D004967	15450(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|amod|END_ENTITY	Estrogen increases hepatic_lipase levels in inbred strains of mice : a possible mechanism for estrogen-dependent lowering of high density lipoprotein .
12193555	0	Estrogen	0,8	hepatocyte_growth_factor	116,140	Estrogen	hepatocyte growth factor	MESH:D004967	15234(Tax:10090)	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|nmod|culture culture|nmod|END_ENTITY	Estrogen mediates mammary epithelial cell proliferation in serum-free culture indirectly via mammary stroma-derived hepatocyte_growth_factor .
15831511	0	Estrogen	0,8	hepatocyte_growth_factor	79,103	Estrogen	hepatocyte growth factor	MESH:D004967	3082	Chemical	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Estrogen and progesterone_receptor expression in macrophages and regulation of hepatocyte_growth_factor by ovarian steroids in women with endometriosis .
12181148	0	Estrogen	0,8	iNOS	19,23	Estrogen	iNOS	MESH:D004967	4843	Chemical	Gene	increases|compound|START_ENTITY END_ENTITY|nsubj|increases	Estrogen increases iNOS expression in the ovine coronary artery .
2484720	0	Estrogen	0,8	insulin-like_growth_factor-I	17,45	Estrogen	insulin-like growth factor-I	MESH:D004967	24482(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Estrogen induces insulin-like_growth_factor-I expression in the rat uterus .
9264503	0	Estrogen	0,8	insulin-like_growth_factor-I	20,48	Estrogen	insulin-like growth factor-I	MESH:D004967	100008668(Tax:9986)	Chemical	Gene	effects|compound|START_ENTITY effects|nmod|END_ENTITY	Estrogen effects on insulin-like_growth_factor-I -LRB- IGF-I -RRB- - induced cell proliferation and IGF-I expression in native and allograft vessels .
16034191	0	Estrogen	0,8	interleukin-18	18,32	Estrogen	interleukin-18	MESH:D004967	16173(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Estrogen inhibits interleukin-18 mRNA expression in the mouse uterus .
10875254	0	Estrogen	0,8	interleukin-6	47,60	Estrogen	interleukin-6	MESH:D004967	3569	Chemical	Gene	modulates|compound|START_ENTITY parathyroid|nsubj|modulates parathyroid|dobj|production production|amod|END_ENTITY	Estrogen modulates parathyroid hormone-induced interleukin-6 production in vivo and in vitro .
11739551	0	Estrogen	0,8	interleukin-6	76,89	Estrogen	interleukin-6	MESH:D004967	16193(Tax:10090)	Chemical	Gene	restores|nsubj|START_ENTITY restores|nmod|mice mice|nmod|suppression suppression|nmod|production production|amod|END_ENTITY	Estrogen restores cellular immunity in injured male mice via suppression of interleukin-6 production .
20043322	0	Estrogen	0,8	interleukin-6	51,64	Estrogen	interleukin-6	MESH:D004967	16193(Tax:10090)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Estrogen stimulates female biliary epithelial cell interleukin-6 expression in mice and humans .
21302136	0	Estrogen	0,8	interleukin-6	82,95	Estrogen	interleukin-6	MESH:D004967	24498(Tax:10116)	Chemical	Gene	suppresses|compound|START_ENTITY metastasis|nsubj|suppresses metastasis|advcl|decreasing decreasing|dobj|expression expression|amod|END_ENTITY	Estrogen suppresses metastasis in rat hepatocellular_carcinoma through decreasing interleukin-6 and hepatocyte_growth_factor expression .
8822343	0	Estrogen	0,8	interleukin-6	18,31	Estrogen	interleukin-6	MESH:D004967	3569	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Estrogen inhibits interleukin-6 production and gene expression in a human osteoblastic cell line with high levels of estrogen receptors .
9712363	0	Estrogen	0,8	interleukin-6	44,57	Estrogen	interleukin-6	MESH:D004967	3569	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Estrogen inhibits interleukin-1beta-induced interleukin-6 production by human osteoblast-like cells .
10750034	0	Estrogen	0,8	keratinocyte_growth_factor	37,63	Estrogen	keratinocyte growth factor	MESH:D004967	14178(Tax:10090)	Chemical	Gene	treatment|compound|START_ENTITY increases|nsubj|treatment increases|dobj|expression expression|compound|END_ENTITY	Estrogen treatment in vivo increases keratinocyte_growth_factor expression in the mammary gland .
8593824	0	Estrogen	0,8	kidney_androgen-regulated_protein	52,85	Estrogen	kidney androgen-regulated protein	MESH:D004967	24937(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Estrogen regulates the stage-specific expression of kidney_androgen-regulated_protein in rat uterus during reproductive cycle and pregnancy .
1584212	0	Estrogen	0,8	lactoferrin	38,49	Estrogen	lactoferrin	MESH:D004967	17002(Tax:10090)	Chemical	Gene	module|compound|START_ENTITY module|nmod|gene gene|compound|END_ENTITY	Estrogen response module of the mouse lactoferrin gene contains overlapping chicken ovalbumin upstream promoter transcription factor and estrogen receptor-binding elements .
11416051	0	Estrogen	0,8	luteinizing_hormone-releasing_hormone	43,80	Estrogen	luteinizing hormone-releasing hormone	MESH:D004967	25194(Tax:10116)	Chemical	Gene	receptor-beta|compound|START_ENTITY immunoreactivity|nsubj|receptor-beta immunoreactivity|nmod|neurons neurons|amod|END_ENTITY	Estrogen receptor-beta immunoreactivity in luteinizing_hormone-releasing_hormone neurons of the rat brain .
11171561	0	Estrogen	0,8	myosin_heavy_chain	37,55	Estrogen	myosin heavy chain	MESH:D004967	100009284(Tax:9986)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	Estrogen modulates the expression of myosin_heavy_chain in detrusor smooth muscle .
14592957	0	Estrogen	0,8	neurokinin_B	23,35	Estrogen	neurokinin B	MESH:D004967	6866	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Estrogen regulation of neurokinin_B gene expression in the mouse arcuate nucleus is mediated by estrogen_receptor_alpha .
12493572	0	Estrogen	0,8	neuromedin_B	19,31	Estrogen	neuromedin B	MESH:D004967	499194(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|effects effects|amod|END_ENTITY	Estrogen modulates neuromedin_B effects on thyrotropin and prolactin release in vitro .
2471980	0	Estrogen	0,8	neuropeptide	34,46	Estrogen	neuropeptide	MESH:D004967	379044(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Estrogen differentially regulates neuropeptide gene expression in a sexually dimorphic olfactory pathway .
17174101	0	Estrogen	0,8	neuropeptide_Y	22,36	Estrogen	neuropeptide Y	MESH:D004967	4852	Chemical	Gene	receptors|compound|START_ENTITY receptors|nmod|neurons neurons|amod|END_ENTITY	Estrogen receptors in neuropeptide_Y neurons : at the crossroads of feeding and reproduction .
9449657	0	Estrogen	0,8	nitric_oxide_synthase	46,67	Estrogen	nitric oxide synthase	MESH:D004967	4843	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	Estrogen upregulates endothelial constitutive nitric_oxide_synthase expression in human osteoblast-like cells .
10465311	0	Estrogen	0,8	osteoprotegerin	62,77	Estrogen	osteoprotegerin	MESH:D004967	4982	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|nmod|END_ENTITY	Estrogen stimulates gene expression and protein production of osteoprotegerin in human osteoblastic cells .
15806305	0	Estrogen	0,8	osteoprotegerin	62,77	Estrogen	osteoprotegerin	MESH:D004967	4982	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|nmod|END_ENTITY	Estrogen specifically stimulates expression and production of osteoprotegerin from rheumatoid synovial fibroblasts .
18771377	0	Estrogen	0,8	osteoprotegerin	33,48	Estrogen	osteoprotegerin	MESH:D004967	4982	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Estrogen regulates expression of osteoprotegerin and RANKL in human periodontal ligament cells through estrogen receptor beta .
19210440	0	Estrogen	0,8	oxytocin	16,24	Estrogen	oxytocin	MESH:D004967	25504(Tax:10116)	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|levels levels|amod|END_ENTITY	Estrogen alters oxytocin mRNA levels in the preoptic area .
7852522	0	Estrogen	0,8	oxytocin	20,28	Estrogen	oxytocin	MESH:D004967	5020	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	Estrogen stimulates oxytocin gene expression in human chorio-decidua .
8713972	0	Estrogen	0,8	oxytocin	23,31	Estrogen	oxytocin	MESH:D004967	18429(Tax:10090)	Chemical	Gene	modulation|compound|START_ENTITY modulation|nmod|END_ENTITY	Estrogen modulation of oxytocin and its relation to behavior .
16254027	0	Estrogen	0,8	oxytocin_receptor	46,63	Estrogen	oxytocin receptor	MESH:D004967	5021	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|nmod|gene gene|compound|END_ENTITY	Estrogen regulates transcription of the ovine oxytocin_receptor gene through GC-rich SP1 promoter elements .
20301197	0	Estrogen	0,8	p21	37,40	Estrogen	p21	MESH:D004967	1026	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|gene gene|amod|END_ENTITY	Estrogen regulated expression of the p21 Waf1/Cip1 gene in estrogen receptor positive human breast_cancer cells .
16900438	0	Estrogen	0,8	p27kip1	56,63	Estrogen	p27kip1	MESH:D004967	83571(Tax:10116)	Chemical	Gene	decrease|nsubj|START_ENTITY decrease|dobj|expression expression|nmod|END_ENTITY	Estrogen and ghrelin decrease cytoplasmic expression of p27kip1 , a cellular marker of ageing , in the striated anal sphincter and levator muscle of ovariectomized rats .
23029392	0	Estrogen	0,8	p27kip1	35,42	Estrogen	p27kip1	MESH:D004967	1027	Chemical	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Estrogen and progesterone regulate p27kip1 levels via the ubiquitin-proteasome system : pathogenic and therapeutic implications for endometrial_cancer .
12377734	0	Estrogen	0,8	p38	95,98	Estrogen	p38	MESH:D004967	1432	Chemical	Gene	regulation|compound|START_ENTITY regulation|dep|role role|nmod|END_ENTITY	Estrogen regulation of endothelial and smooth muscle cell migration and proliferation : role of p38 and p42/44 mitogen-activated protein kinase .
21475909	0	Estrogen	0,8	p75NTR	56,62	Estrogen	p75NTR	MESH:D004967	4804	Chemical	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	Estrogen in combination with 5-azacitidine up-regulates p75NTR expression and induces apoptosis in 22Rv1 prostate_cancer cells .
20713969	0	Estrogen	0,8	parvalbumin	18,29	Estrogen	parvalbumin	MESH:D004967	19293(Tax:10090)	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|compound|END_ENTITY	Estrogen promotes parvalbumin expression in arcuate nucleus POMC neurons .
8977427	0	Estrogen	0,8	peptidylglycine_alpha-amidating_monooxygenase	23,68	Estrogen	peptidylglycine alpha-amidating monooxygenase	MESH:D004967	25508(Tax:10116)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Estrogen regulation of peptidylglycine_alpha-amidating_monooxygenase expression in anterior pituitary gland .
18562618	0	Estrogen	0,8	phosphatidylinositol_3-kinase	26,55	Estrogen	phosphatidylinositol 3-kinase	MESH:D004967	5293	Chemical	Gene	facilitates|nsubj|START_ENTITY facilitates|dobj|Akt Akt|amod|END_ENTITY	Estrogen facilitates both phosphatidylinositol_3-kinase / Akt and ERK1/2 mitogen-activated protein kinase membrane signaling required for long-term neuropeptide_Y transcriptional regulation in clonal , immortalized neurons .
23872150	0	Estrogen	0,8	plasminogen	19,30	Estrogen	plasminogen	MESH:D004967	5340	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activity activity|amod|END_ENTITY	Estrogen modulates plasminogen promoter activity .
9149111	0	Estrogen	0,8	pro-opiomelanocortin	31,51	Estrogen	pro-opiomelanocortin	MESH:D004967	24664(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Estrogen inhibits hypothalamic pro-opiomelanocortin gene expression in hypothalamic neuronal_cultures .
2464133	0	Estrogen	0,8	proenkephalin	19,32	Estrogen	proenkephalin	MESH:D004967	29237(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|ccomp|ribonucleic_acid ribonucleic_acid|nsubj|messenger messenger|compound|END_ENTITY	Estrogen increases proenkephalin messenger ribonucleic_acid levels in the ventromedial hypothalamus of the rat .
2927283	0	Estrogen	0,8	proenkephalin	23,36	Estrogen	proenkephalin	MESH:D004967	29237(Tax:10116)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Estrogen regulation of proenkephalin gene expression in the ventromedial hypothalamus of the rat : temporal qualities and synergism with progesterone .
9147295	0	Estrogen	0,8	proenkephalin	80,93	Estrogen	proenkephalin	MESH:D004967	5179	Chemical	Gene	interact|nsubj|START_ENTITY interact|xcomp|regulate regulate|dobj|expression expression|nmod|gene gene|amod|END_ENTITY	Estrogen and stress interact to regulate the hypothalamic expression of a human proenkephalin promoter-beta-galactosidase fusion gene in a site-specific and sex-specific manner .
9295199	0	Estrogen	0,8	proenkephalin	16,29	Estrogen	proenkephalin	MESH:D004967	29237(Tax:10116)	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|RNAs RNAs|compound|END_ENTITY	Estrogen alters proenkephalin RNAs in the paraventricular nucleus of the hypothalamus following stress .
748014	0	Estrogen	0,8	progesterone_receptor	20,41	Estrogen	progesterone receptor	MESH:D004967	5241	Chemical	Gene	control|compound|START_ENTITY control|nmod|END_ENTITY	Estrogen control of progesterone_receptor in human breast_cancer : role of estradiol and antiestrogen .
11075818	0	Estrogen	0,8	prolactin	23,32	Estrogen	prolactin	MESH:D004967	24683(Tax:10116)	Chemical	Gene	modulation|compound|START_ENTITY modulation|nmod|expression expression|amod|END_ENTITY	Estrogen modulation of prolactin gene expression requires an intact mitogen-activated protein kinase signal transduction pathway in cultured rat pituitary cells .
17558189	0	Estrogen	0,8	prolactin	53,62	Estrogen	prolactin	MESH:D004967	19109(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|level level|nmod|END_ENTITY	Estrogen regulates the serum level of phosphorylated prolactin in mice .
18832099	0	Estrogen	0,8	prolactin	72,81	Estrogen	prolactin	MESH:D004967	24683(Tax:10116)	Chemical	Gene	receptor-alpha|compound|START_ENTITY mediates|nsubj|receptor-alpha mediates|dobj|expression expression|compound|END_ENTITY	Estrogen receptor-alpha mediates the epidermal_growth_factor-stimulated prolactin expression and release in lactotrophs .
2602387	0	Estrogen	0,8	prolactin	25,34	Estrogen	prolactin	MESH:D004967	24683(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Estrogen stimulates both prolactin and growth_hormone mRNAs expression in the MtT/F4 transplantable pituitary_tumor .
282615	0	Estrogen	0,8	prolactin	20,29	Estrogen	prolactin	MESH:D004967	24683(Tax:10116)	Chemical	Gene	control|compound|START_ENTITY control|nmod|synthesis synthesis|compound|END_ENTITY	Estrogen control of prolactin synthesis in vitro .
2909367	0	Estrogen	0,8	prolactin	23,32	Estrogen	prolactin	MESH:D004967	24683(Tax:10116)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|transcription transcription|compound|END_ENTITY	Estrogen regulation of prolactin gene transcription in vivo : paradoxical effects of 17_beta-estradiol dose .
3996322	0	Estrogen	0,8	prolactin	48,57	Estrogen	prolactin	MESH:D004967	24683(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|nmod|gene gene|compound|END_ENTITY	Estrogen regulates the transcription of the rat prolactin gene in vivo through at least two independent mechanisms .
4092669	0	Estrogen	0,8	prolactin	17,26	Estrogen	prolactin	MESH:D004967	24683(Tax:10116)	Chemical	Gene	induced|nsubj|START_ENTITY induced|dobj|accumulation accumulation|amod|END_ENTITY	Estrogen induced prolactin mRNA accumulation in adult male rat pituitary as revealed by in situ hybridization .
6201347	0	Estrogen	0,8	prolactin	20,29	Estrogen	prolactin	MESH:D004967	24683(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|transcription transcription|amod|END_ENTITY	Estrogen stimulates prolactin gene transcription by a mechanism independent of pituitary protein synthesis .
7619813	0	Estrogen	0,8	prolactin	84,93	Estrogen	prolactin	MESH:D004967	24683(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY receptor|dep|affinity affinity|nmod|elements elements|nmod|gene gene|compound|END_ENTITY	Estrogen receptor binding to DNA : affinity for nonpalindromic elements from the rat prolactin gene .
9879662	0	Estrogen	0,8	raf-1	19,24	Estrogen	raf-1	MESH:D004967	5894	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|kinase kinase|amod|END_ENTITY	Estrogen activates raf-1 kinase and induces expression of Egr-1 in MCF-7 breast_cancer cells .
11121427	0	Estrogen	0,8	receptor_activator_of_NF-kappa_B_ligand	59,98	Estrogen	receptor activator of NF-kappa B ligand	MESH:D004967	21943(Tax:10090)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|nmod|END_ENTITY	Estrogen decreases osteoclast formation by down-regulating receptor_activator_of_NF-kappa_B_ligand -LRB- RANKL -RRB- - induced JNK activation .
3721058	0	Estrogen	0,8	retinol-binding_protein	23,46	Estrogen	retinol-binding protein	MESH:D004967	5950	Chemical	Gene	modulation|compound|START_ENTITY modulation|nmod|END_ENTITY	Estrogen modulation of retinol-binding_protein in immature chicks : comparison with riboflavin_carrier_protein .
22302680	0	Estrogen	0,8	reversion-inducing_cysteine-rich_protein_with_Kazal_motifs	73,131	Estrogen	reversion-inducing cysteine-rich protein with Kazal motifs	MESH:D004967	53614(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|nmod|END_ENTITY	Estrogen suppresses expression of the matrix metalloproteinase inhibitor reversion-inducing_cysteine-rich_protein_with_Kazal_motifs -LRB- RECK -RRB- within the mouse uterus .
15044260	0	Estrogen	0,8	secretory_leukocyte_protease_inhibitor	31,69	Estrogen	secretory leukocyte protease inhibitor	MESH:D004967	84386(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Estrogen induces expression of secretory_leukocyte_protease_inhibitor in rat uterus .
12051724	0	Estrogen	0,8	serum_response_factor	107,128	Estrogen	serum response factor	MESH:D004967	6722	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Estrogen regulation of c-fos gene expression through phosphatidylinositol-3-kinase-dependent activation of serum_response_factor in MCF-7 breast_cancer cells .
2278857	0	Estrogen	0,8	sex_hormone_binding_globulin	36,64	Estrogen	sex hormone binding globulin	MESH:D004967	6462	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Estrogen and androgen regulation of sex_hormone_binding_globulin secretion by a human liver cell line .
25664066	0	Estrogen	0,8	stromal_cell_derived_factor-1	32,61	Estrogen	stromal cell derived factor-1	MESH:D004967	6387	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|secretion secretion|nmod|END_ENTITY	Estrogen increases secretion of stromal_cell_derived_factor-1 in human breast_cancer cells .
19391135	0	Estrogen	0,8	thrombospondin-1	23,39	Estrogen	thrombospondin-1	MESH:D004967	7057	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Estrogen regulation of thrombospondin-1 in human breast_cancer cells .
9609507	0	Estrogen	0,8	thyrotropin-releasing_hormone	49,78	Estrogen	thyrotropin-releasing hormone	MESH:D004967	25569(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	Estrogen suppresses gastric motility response to thyrotropin-releasing_hormone and stress in awake rats .
2500332	0	Estrogen	0,8	tissue_plasminogen_activator	59,87	Estrogen	tissue plasminogen activator	MESH:D004967	100128998	Chemical	Gene	regulation|compound|START_ENTITY line|nsubj|regulation line|dobj|END_ENTITY	Estrogen regulation of human breast_cancer cell line MCF-7 tissue_plasminogen_activator .
3087011	0	Estrogen	0,8	tissue_plasminogen_activator	23,51	Estrogen	tissue plasminogen activator	MESH:D004967	100128998	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Estrogen regulation of tissue_plasminogen_activator in a human melanoma cell line .
12459033	0	Estrogen	0,8	transferrin	23,34	Estrogen	transferrin	MESH:D004967	7018	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Estrogen regulation of transferrin gene expression in MCF-7 human breast_cancer cells .
3785157	0	Estrogen	0,8	transferrin	33,44	Estrogen	transferrin	MESH:D004967	22041(Tax:10090)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|gene gene|compound|END_ENTITY	Estrogen regulation of the avian transferrin gene in transgenic_mice .
15076322	0	Estrogen	0,8	transforming_growth_factor-beta	100,131	Estrogen	transforming growth factor-beta	MESH:D004967	7040	Chemical	Gene	induction|compound|START_ENTITY mediated|nsubjpass|induction mediated|nmod|END_ENTITY	Estrogen induction of smooth muscle differentiation of human prostatic stromal cells is mediated by transforming_growth_factor-beta .
11306168	0	Estrogen	0,8	transforming_growth_factorbeta	37,67	Estrogen	transforming growth factorbeta	MESH:D004967	7040	Chemical	Gene	actions|compound|START_ENTITY actions|nmod|END_ENTITY	Estrogen and antiestrogen actions on transforming_growth_factorbeta -LRB- TGFbeta -RRB- in normal human breast epithelial -LRB- HBE -RRB- cells .
15345812	0	Estrogen	0,8	transthyretin	57,70	Estrogen	transthyretin	MESH:D004967	22139(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Estrogen increases brain expression of the mRNA encoding transthyretin , an amyloid beta scavenger protein .
16118792	0	Estrogen	0,8	trkA	16,20	Estrogen	trkA	MESH:D004967	59109(Tax:10116)	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|expression expression|compound|END_ENTITY	Estrogen alters trkA and p75 neurotrophin receptor expression within sympathetic neurons .
22669426	0	Estrogen	0,8	tropoelastin	26,38	Estrogen	tropoelastin	MESH:D004967	2006	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Estrogen inhibits vaginal tropoelastin and TGF-b1 production .
16458260	0	Estrogen	0,8	tryptophan_hydroxylase-2	31,55	Estrogen	tryptophan hydroxylase-2	MESH:D004967	317675(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Estrogen selectively increases tryptophan_hydroxylase-2 mRNA expression in distinct subregions of rat midbrain raphe nucleus : association between gene expression and anxiety_behavior in the open field .
24033289	0	Estrogen	0,8	tryptophan_hydroxylase-2	36,60	Estrogen	tryptophan hydroxylase-2	MESH:D004967	121278	Chemical	Gene	receptor-b|compound|START_ENTITY regulates|nsubj|receptor-b regulates|dobj|END_ENTITY	Estrogen receptor-b regulates human tryptophan_hydroxylase-2 through an estrogen response element in the 5 ' untranslated region .
2281828	0	Estrogen	0,8	tumor_necrosis_factor	29,50	Estrogen	tumor necrosis factor	MESH:D004967	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|nmod|END_ENTITY	Estrogen inhibits release of tumor_necrosis_factor from peripheral blood mononuclear cells in postmenopausal women .
12231436	0	Estrogen	0,8	tumor_necrosis_factor-alpha	20,47	Estrogen	tumor necrosis factor-alpha	MESH:D004967	24835(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|amod|END_ENTITY	Estrogen attenuates tumor_necrosis_factor-alpha expression to provide ischemic neuroprotection in female rats .
16288994	0	Estrogen	0,8	tumor_necrosis_factor-alpha	44,71	Estrogen	tumor necrosis factor-alpha	MESH:D004967	21926(Tax:10090)	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|expression expression|amod|END_ENTITY	Estrogen receptor-independent inhibition of tumor_necrosis_factor-alpha gene expression by phytoestrogen equol is mediated by blocking nuclear factor-kappaB activation in mouse macrophages .
16403479	0	Estrogen	0,8	tumor_necrosis_factor-alpha	76,103	Estrogen	tumor necrosis factor-alpha	MESH:D004967	24835(Tax:10116)	Chemical	Gene	improves|nsubj|START_ENTITY improves|nmod|END_ENTITY	Estrogen improves cardiac recovery after ischemia/reperfusion by decreasing tumor_necrosis_factor-alpha .
12555275	0	Estrogen	0,8	tyrosine_hydroxylase	19,39	Estrogen	tyrosine hydroxylase	MESH:D004967	21823(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Estrogen regulates tyrosine_hydroxylase expression in the neonate mouse midbrain .
12429382	0	Estrogen	0,8	vascular_endothelial_growth_factor	17,51	Estrogen	vascular endothelial growth factor	MESH:D004967	22339(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|amod|END_ENTITY	Estrogen reduces vascular_endothelial_growth_factor -LRB- 164 -RRB- expression in the mouse nucleus paraventricularis of the hypothalamus .
14647449	0	Estrogen	0,8	vascular_endothelial_growth_factor	23,57	Estrogen	vascular endothelial growth factor	MESH:D004967	7422	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Estrogen regulation of vascular_endothelial_growth_factor gene expression in ZR-75 breast_cancer cells through interaction of estrogen_receptor_alpha and SP proteins .
19398483	0	Estrogen	0,8	vascular_endothelial_growth_factor	23,57	Estrogen	vascular endothelial growth factor	MESH:D004967	7422	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Estrogen regulation of vascular_endothelial_growth_factor in breast_cancer in vitro and in vivo : the role of estrogen_receptor_alpha and c-Myc .
19828145	0	Estrogen	0,8	vascular_endothelial_growth_factor	108,142	Estrogen	vascular endothelial growth factor	MESH:D004967	7422	Chemical	Gene	modulators|nsubj|START_ENTITY modulators|xcomp|regulate regulate|dobj|receptor receptor|compound|END_ENTITY	Estrogen and selective estrogen receptor modulators regulate vascular_endothelial_growth_factor and soluble vascular_endothelial_growth_factor receptor 1 in human endometrial stromal cells .
19828145	0	Estrogen	0,8	vascular_endothelial_growth_factor	61,95	Estrogen	vascular endothelial growth factor	MESH:D004967	7422	Chemical	Gene	modulators|nsubj|START_ENTITY modulators|xcomp|regulate regulate|dobj|receptor receptor|compound|END_ENTITY	Estrogen and selective estrogen receptor modulators regulate vascular_endothelial_growth_factor and soluble vascular_endothelial_growth_factor receptor 1 in human endometrial stromal cells .
20666947	0	Estrogen	0,8	vascular_endothelial_growth_factor	90,124	Estrogen	vascular endothelial growth factor	MESH:D004967	22339(Tax:10090)	Chemical	Gene	administration|compound|START_ENTITY increases|nsubj|administration increases|dobj|quality quality|nmod|synthase synthase|compound|END_ENTITY	Estrogen administration during superovulation increases oocyte quality and expressions of vascular_endothelial_growth_factor and nitric_oxide synthase in the ovary .
24938798	0	Estrogen	0,8	vitellogenin_II	50,65	Estrogen	vitellogenin II	MESH:D004967	424533(Tax:9031)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|nmod|END_ENTITY	Estrogen stimulates expression of chicken hepatic vitellogenin_II and very low-density apolipoprotein II through ER-a .
3244357	0	Estrogen	0,8	vitellogenin_II	64,79	Estrogen	vitellogenin II	MESH:D004967	424533(Tax:9031)	Chemical	Gene	sites|compound|START_ENTITY sites|nmod|gene gene|compound|END_ENTITY	Estrogen and progesterone_receptor-binding sites on the chicken vitellogenin_II gene : synergism of steroid hormone action .
20571400	0	Estrogens	0,9	FGF23	62,67	Estrogens	FGF23	MESH:D004967	8074	Chemical	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Estrogens and bone_disease in chronic_kidney_disease : role of FGF23 .
21153241	0	Estrogens	0,9	corticotropin-releasing_factor	37,67	Estrogens	corticotropin-releasing factor	MESH:D004967	81648(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|gene gene|amod|END_ENTITY	Estrogens decrease expression of the corticotropin-releasing_factor gene in the hypothalamic paraventricular nucleus and of the proopiomelanocortin gene in the anterior pituitary of ovariectomized rats .
1572285	0	Estrogens	0,9	estrogen_receptor	100,117	Estrogens	estrogen receptor	MESH:D004967	2099	Chemical	Gene	modulate|nsubj|START_ENTITY modulate|dobj|responsiveness responsiveness|nmod|cells cells|acl|transfected transfected|nmod|END_ENTITY	Estrogens modulate the responsiveness of osteoblast-like cells -LRB- ROS 17/2 .8 -RRB- stably transfected with estrogen_receptor .
23761784	0	Estrogens	0,9	growth_hormone	42,56	Estrogens	growth hormone	MESH:D004967	2688	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|effects effects|nmod|END_ENTITY	Estrogens regulate the hepatic effects of growth_hormone , a hormonal interplay with multiple fates .
10884367	0	Estrogens	0,9	vascular_cell_adhesion_molecule-1	50,83	Estrogens	vascular cell adhesion molecule-1	MESH:D004967	7412	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|expression expression|amod|END_ENTITY	Estrogens and glucocorticoids inhibit endothelial vascular_cell_adhesion_molecule-1 expression by different transcriptional mechanisms .
18395502	0	Estrogens	0,9	vascular_endothelial_growth_factor	110,144	Estrogens	vascular endothelial growth factor	MESH:D004967	7422	Chemical	Gene	stimulate|nsubj|START_ENTITY stimulate|advcl|inducing inducing|dobj|expression expression|nmod|END_ENTITY	Estrogens stimulate the proliferation of human cholangiocarcinoma by inducing the expression and secretion of vascular_endothelial_growth_factor .
20004694	0	Estrogens	0,9	visfatin	17,25	Estrogens	visfatin	MESH:D004967	59027(Tax:10090)	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|compound|END_ENTITY	Estrogens induce visfatin expression in 3T3-L1 cells .
6581863	0	Estrone	0,7	sulfatase	35,44	Estrone	sulfatase	MESH:D004970	347527	Chemical	Gene	START_ENTITY|dobj|activities activities|amod|END_ENTITY	Estrone and dehydroepiandrosterone sulfatase activities and plasma estrone_sulfate levels in human breast_carcinoma .
7792836	0	Estrone_sulfate	0,15	estrone_sulfatase	27,44	Estrone sulfate	estrone sulfatase	MESH:C017296	412	Chemical	Gene	analogs|nsubj|START_ENTITY analogs|nmod|inhibitors inhibitors|amod|END_ENTITY	Estrone_sulfate analogs as estrone_sulfatase inhibitors .
2298851	0	Estrone_sulfate	0,15	sulfatase	16,25	Estrone sulfate	sulfatase	MESH:C017296	347527	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Estrone_sulfate sulfatase activity is increased during in vitro decidualization of stromal cells from human endometrium .
10065532	0	Et2SnCl2	15,23	GMP	43,46	Et2SnCl2	GMP	null	22978	Chemical	Gene	Interaction|nmod|START_ENTITY END_ENTITY|nsubj|Interaction	Interaction of Et2SnCl2 with 5 ' - IMP and 5 ' - GMP .
24296323	0	Etamicastat	0,11	dopamine_b-hydroxylase	21,43	Etamicastat	dopamine b-hydroxylase	MESH:C509002	1621	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Etamicastat , a novel dopamine_b-hydroxylase inhibitor : tolerability , pharmacokinetics , and pharmacodynamics in patients with hypertension .
23082001	0	Ethacrynic_acid	0,15	glutathione_S-transferase_p1-1	128,158	Ethacrynic acid	glutathione S-transferase p1-1	MESH:D004976	2950	Chemical	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Ethacrynic_acid and a derivative enhance apoptosis in arsenic_trioxide-treated myeloid_leukemia and lymphoma cells : the role of glutathione_S-transferase_p1-1 .
3597427	0	Ethanenitronate	0,15	catalase	62,70	Ethanenitronate	catalase	MESH:C053154	531682(Tax:9913)	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Ethanenitronate is a peroxide-dependent suicide substrate for catalase .
19356968	0	Ethanol	0,7	ALDH2	22,27	Ethanol	ALDH2	MESH:D000431	11669(Tax:10090)	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|nmod|mice mice|compound|END_ENTITY	Ethanol metabolism in ALDH2 knockout mice -- blood acetate levels .
25524103	0	Ethanol	69,76	Alcohol_Dehydrogenase	37,58	Ethanol	Alcohol Dehydrogenase	MESH:D000431	13909458	Chemical	Gene	Production|compound|START_ENTITY Production|compound|END_ENTITY	Fusion of Pyruvate Decarboxylase and Alcohol_Dehydrogenase Increases Ethanol Production in Escherichia_coli .
17236798	0	Ethanol	0,7	Aldh9	19,24	Ethanol	Aldh9	MESH:D000431	100049493(Tax:8090)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|amod|END_ENTITY	Ethanol attenuates Aldh9 mRNA expression in Japanese_medaka -LRB- Oryzias_latipes -RRB- embryogenesis .
21051534	0	Ethanol	0,7	CYP2A5	21,27	Ethanol	CYP2A5	MESH:D000431	13087(Tax:10090)	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Ethanol induction of CYP2A5 : permissive role for CYP2E1 .
22552773	0	Ethanol	0,7	CYP2A5	21,27	Ethanol	CYP2A5	MESH:D000431	13087(Tax:10090)	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Ethanol induction of CYP2A5 : role of CYP2E1-ROS-Nrf2 pathway .
10718635	0	Ethanol	0,7	CYP2E1	108,114	Ethanol	CYP2E1	MESH:D000431	25086(Tax:10116)	Chemical	Gene	produce|nsubj|START_ENTITY produce|nmod|levels levels|nmod|END_ENTITY	Ethanol and arachidonic_acid produce toxicity in hepatocytes from pyrazole-treated rats with high levels of CYP2E1 .
11755313	0	Ethanol	0,7	CYP2E1	27,33	Ethanol	CYP2E1	MESH:D000431	25086(Tax:10116)	Chemical	Gene	withdrawal|amod|START_ENTITY withdrawal|acl|induced induced|dobj|degradation degradation|compound|END_ENTITY	Ethanol withdrawal induced CYP2E1 degradation in vivo , blocked by proteasomal inhibitor PS-341 .
17660004	0	Ethanol	0,7	CYP2E1	97,103	Ethanol	CYP2E1	MESH:D000431	1571	Chemical	Gene	enhanced|nsubj|START_ENTITY enhanced|nmod|induction induction|nummod|END_ENTITY	Ethanol enhanced the genotoxicity of acrylamide in human , metabolically competent HepG2 cells by CYP2E1 induction and glutathione depletion .
21051534	0	Ethanol	0,7	CYP2E1	49,55	Ethanol	CYP2E1	MESH:D000431	13106(Tax:10090)	Chemical	Gene	induction|amod|START_ENTITY induction|dep|role role|nmod|END_ENTITY	Ethanol induction of CYP2A5 : permissive role for CYP2E1 .
8530344	0	Ethanol	0,7	CYP2E1	16,22	Ethanol	CYP2E1	MESH:D000431	1571	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Ethanol induces CYP2E1 by protein stabilization .
19177030	0	Ethanol	0,7	Cyp2e1	77,83	Ethanol	Cyp2e1	MESH:D000431	13106(Tax:10090)	Chemical	Gene	intake|amod|START_ENTITY intake|nmod|mice mice|amod|END_ENTITY	Ethanol intake and ethanol-induced locomotion_and_locomotor_sensitization in Cyp2e1 knockout mice .
26727525	0	Ethanol	19,26	Cytochrome_P450	93,108	Ethanol	Cytochrome P450	MESH:D000431	4051	Chemical	Gene	Darunavir/Ritonavir|compound|START_ENTITY Effects|nmod|Darunavir/Ritonavir Effects|dep|Regulation Regulation|nmod|END_ENTITY	Chronic Effects of Ethanol and/or Darunavir/Ritonavir on U937 Monocytic Cells : Regulation of Cytochrome_P450 and Antioxidant Enzymes , Oxidative Stress , and Cytotoxicity .
15547463	0	Ethanol	0,7	EAAT1	57,62	Ethanol	EAAT1	MESH:D000431	29483(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Ethanol induces expression of the glutamate transporters EAAT1 and EAAT2 in organotypic cortical slice cultures .
15729141	0	Ethanol	0,7	GAD67	16,21	Ethanol	GAD67	MESH:D000431	24379(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Ethanol induces GAD67 and VGAT in slice cultures of newborn rat cerebral cortex .
16009711	0	Ethanol	0,7	H-Ras	94,99	Ethanol	H-Ras	MESH:D000431	3265	Chemical	Gene	alters|nsubj|START_ENTITY alters|nmod|END_ENTITY	Ethanol alters trafficking and functional N-methyl-D-aspartate receptor NR2 subunit ratio via H-Ras .
26079697	0	Ethanol	0,7	HMGB1	25,30	Ethanol	HMGB1	MESH:D000431	3146	Chemical	Gene	induced|nsubj|START_ENTITY induced|dobj|release release|compound|END_ENTITY	Ethanol directly induced HMGB1 release through NOX2/NLRP1 inflammasome in neuronal cells .
8408032	0	Ethanol	0,7	IGF-1	78,83	Ethanol	IGF-1	MESH:D000431	3479	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|autophosphorylation autophosphorylation|nmod|receptor receptor|appos|END_ENTITY	Ethanol inhibits the autophosphorylation of the insulin-like_growth_factor_1 -LRB- IGF-1 -RRB- receptor and IGF-1-mediated proliferation of 3T3 cells .
9450501	0	Ethanol	0,7	IGF-1	37,42	Ethanol	IGF-1	MESH:D000431	24482(Tax:10116)	Chemical	Gene	blocks|nsubj|START_ENTITY blocks|dobj|action action|nmod|END_ENTITY	Ethanol blocks the central action of IGF-1 to induce luteinizing hormone secretion in the prepubertal female rat .
16343492	0	Ethanol	0,7	JNK	37,40	Ethanol	JNK	MESH:D000431	116554(Tax:10116)	Chemical	Gene	causes|nsubj|START_ENTITY causes|dobj|activation activation|nmod|END_ENTITY	Ethanol rapidly causes activation of JNK associated with ER stress under inhibition of ADH .
22454661	0	Ethanol	0,7	JNK	172,175	Ethanol	JNK	MESH:D000431	5599	Chemical	Gene	extracts|amod|START_ENTITY extracts|acl|migration migration|advcl|inhibiting inhibiting|xcomp|matrix_metalloproteinase-2 matrix_metalloproteinase-2|nmod|END_ENTITY	Ethanol extracts of fruiting bodies of Antrodia cinnamomea suppress CL1-5 human lung_adenocarcinoma cells migration by inhibiting matrix_metalloproteinase-2 / 9 through ERK , JNK , p38 , and PI3K/Akt signaling pathways .
11079460	0	Ethanol	0,7	NFkappaB	37,45	Ethanol	NFkappaB	MESH:D000431	4790	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activation activation|compound|END_ENTITY	Ethanol enhances TNF-alpha-inducible NFkappaB activation and HIV-1-LTR transcription in CD4 + Jurkat T lymphocytes .
24244322	0	Ethanol	0,7	NLRP3	31,36	Ethanol	NLRP3	MESH:D000431	114548	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	Ethanol inhibits activation of NLRP3 and AIM2 inflammasomes in human macrophages -- a novel anti-inflammatory action of alcohol .
9922992	0	Ethanol	0,7	P450	43,47	Ethanol	P450	MESH:D000431	1555	Chemical	Gene	interactions|amod|START_ENTITY interactions|nmod|END_ENTITY	Ethanol interactions with other cytochrome P450 substrates including drugs , xenobiotics , and carcinogens .
25099937	0	Ethanol	0,7	PGC-1a	19,25	Ethanol	PGC-1a	MESH:D000431	10891	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Ethanol suppresses PGC-1a expression by interfering with the cAMP-CREB pathway in neuronal cells .
12163172	0	Ethanol	0,7	STAT3	32,37	Ethanol	STAT3	MESH:D000431	6774	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|compound|END_ENTITY	Ethanol inhibits leptin-induced STAT3 activation in Huh7 cells .
17074062	0	Ethanol	0,7	TRPM8	39,44	Ethanol	TRPM8	MESH:D000431	79054	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Ethanol inhibits cold-menthol receptor TRPM8 by modulating its interaction with membrane phosphatidylinositol_4 ,5 - bisphosphate .
22995443	0	Ethanol	0,7	TrkB	105,109	Ethanol	TrkB	MESH:D000431	25054(Tax:10116)	Chemical	Gene	extracts|amod|START_ENTITY attenuate|nsubj|extracts attenuate|dobj|decreases decreases|nmod|levels levels|amod|END_ENTITY	Ethanol extracts from Hemerocallis citrina attenuate the decreases of brain-derived_neurotrophic_factor , TrkB levels in rat induced by corticosterone administration .
17077538	0	Ethanol	144,151	acetylcholinesterase	77,97	Ethanol	acetylcholinesterase	MESH:D000431	43	Chemical	Gene	extract|compound|START_ENTITY activity|nmod|extract activity|amod|END_ENTITY	8-hydroxydihydrochelerythrine and 8-hydroxydihydrosanguinarine with a potent acetylcholinesterase inhibitory activity from Chelidonium majus L. Ethanol extract of the aerial portion of Chelidonium majus L. inhibited acetylcholinesterase -LRB- AChE -RRB- activity without a significant inhibition of butyrylcholinesterase -LRB- BuChE -RRB- .
17888594	0	Ethanol	0,7	acetylcholinesterase	15,35	Ethanol	acetylcholinesterase	MESH:D000431	114549(Tax:7955)	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|activity activity|amod|END_ENTITY	Ethanol alters acetylcholinesterase activity and gene expression in zebrafish brain .
3391254	0	Ethanol	0,7	acetylcholinesterase	149,169	Ethanol	acetylcholinesterase	MESH:D000431	83817(Tax:10116)	Chemical	Gene	exposure|amod|START_ENTITY alters|nsubj|exposure alters|parataxis|analysis analysis|nmod|histochemistry histochemistry|amod|END_ENTITY	Ethanol exposure following unilateral entorhinal deafferentation alters synaptic reorganization in the rat dentate gyrus : a quantitative analysis of acetylcholinesterase histochemistry .
21166830	0	Ethanol	0,7	alcohol_dehydrogenase	55,76	Ethanol	alcohol dehydrogenase	MESH:D000431	10327	Chemical	Gene	metabolism|amod|START_ENTITY transduced|nsubj|metabolism transduced|nmod|isoenzymes isoenzymes|compound|END_ENTITY	Ethanol metabolism by HeLa cells transduced with human alcohol_dehydrogenase isoenzymes : control of the pathway by acetaldehyde concentration .
25447342	0	Ethanol	0,7	alcohol_dehydrogenase	68,89	Ethanol	alcohol dehydrogenase	MESH:D000431	58810(Tax:10090)	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|END_ENTITY	Ethanol at low concentrations protects glomerular podocytes through alcohol_dehydrogenase and 20-HETE .
463453	0	Ethanol	0,7	alcohol_dehydrogenase	60,81	Ethanol	alcohol dehydrogenase	MESH:D000431	78959(Tax:10116)	Chemical	Gene	elimination|amod|START_ENTITY elimination|dep|roles roles|nmod|END_ENTITY	Ethanol elimination in regenerating rat liver : the roles of alcohol_dehydrogenase and acetaldehyde .
6987987	0	Ethanol	0,7	alcohol_dehydrogenase	58,79	Ethanol	alcohol dehydrogenase	MESH:D000431	10327	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|amod|deficient deficient|nmod|END_ENTITY	Ethanol metabolism in Peromyscus genetically deficient in alcohol_dehydrogenase .
8003657	0	Ethanol	0,7	alcohol_dehydrogenase	60,81	Ethanol	alcohol dehydrogenase	MESH:D000431	78959(Tax:10116)	Chemical	Gene	consumption|amod|START_ENTITY related|nsubjpass|consumption related|nmod|activity activity|compound|END_ENTITY	Ethanol consumption by rats is inversely related to hepatic alcohol_dehydrogenase activity .
8214435	0	Ethanol	0,7	alcohol_dehydrogenase	53,74	Ethanol	alcohol dehydrogenase	MESH:D000431	10327	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|dep|role role|nmod|END_ENTITY	Ethanol metabolism in deermice : role of extrahepatic alcohol_dehydrogenase .
992568	0	Ethanol	0,7	alcohol_dehydrogenase	87,108	Ethanol	alcohol dehydrogenase	MESH:D000431	78959(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|dep|involvement involvement|nmod|END_ENTITY	Ethanol metabolism in perfused rat liver at low ethanol concentrations : involvement of alcohol_dehydrogenase in the adaptive increase in ethanol metabolism due to chronic pretreatment with ethanol .
10448196	0	Ethanol	0,7	beta-endorphin	76,90	Ethanol	beta-endorphin	MESH:D000431	18976(Tax:10090)	Chemical	Gene	self-administration|amod|START_ENTITY increased|nsubjpass|self-administration increased|nmod|expression expression|amod|END_ENTITY	Ethanol oral self-administration is increased in mutant mice with decreased beta-endorphin expression .
2958786	0	Ethanol	0,7	beta-endorphin	25,39	Ethanol	beta-endorphin	MESH:D000431	18976(Tax:10090)	Chemical	Gene	treatment|amod|START_ENTITY alters|nsubj|treatment alters|dobj|metabolism metabolism|amod|END_ENTITY	Ethanol treatment alters beta-endorphin metabolism by purified synaptosomal plasma membranes .
11948666	0	Ethanol	0,7	brain-derived_neurotrophic_factor	80,113	Ethanol	brain-derived neurotrophic factor	MESH:D000431	627	Chemical	Gene	exposure|amod|START_ENTITY enhances|nsubj|exposure enhances|nmod|cortex cortex|dep|role role|nmod|END_ENTITY	Ethanol exposure enhances cell death in the developing cerebral cortex : role of brain-derived_neurotrophic_factor and its signaling pathways .
16938627	0	Ethanol	0,7	brain-derived_neurotrophic_factor	17,50	Ethanol	brain-derived neurotrophic factor	MESH:D000431	627	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|stimulation stimulation|amod|END_ENTITY	Ethanol inhibits brain-derived_neurotrophic_factor stimulation of extracellular signal-regulated/mitogen-activated protein kinase in cerebellar granule cells .
22995443	0	Ethanol	0,7	brain-derived_neurotrophic_factor	70,103	Ethanol	brain-derived neurotrophic factor	MESH:D000431	24225(Tax:10116)	Chemical	Gene	extracts|amod|START_ENTITY attenuate|nsubj|extracts attenuate|dobj|decreases decreases|nmod|levels levels|amod|END_ENTITY	Ethanol extracts from Hemerocallis citrina attenuate the decreases of brain-derived_neurotrophic_factor , TrkB levels in rat induced by corticosterone administration .
20004340	0	Ethanol	0,7	c-Fos	34,39	Ethanol	c-Fos	MESH:D000431	2353	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|expressions expressions|nmod|END_ENTITY	Ethanol alters the expressions of c-Fos and myelin_basic_protein in differentiating oligodendrocytes .
2107390	0	Ethanol	0,7	c-fos	46,51	Ethanol	c-fos	MESH:D000431	14281(Tax:10090)	Chemical	Gene	withdrawal_seizures|amod|START_ENTITY produce|nsubj|withdrawal_seizures produce|dobj|mRNA mRNA|amod|END_ENTITY	Ethanol withdrawal_seizures produce increased c-fos mRNA in mouse brain .
15276784	0	Ethanol	0,7	catalase	58,66	Ethanol	catalase	MESH:D000431	12359(Tax:10090)	Chemical	Gene	intake|amod|START_ENTITY intake|dep|role role|nmod|activity activity|compound|END_ENTITY	Ethanol intake and motor sensitization : the role of brain catalase activity in mice with different genotypes .
18797246	0	Ethanol	0,7	catalase	118,126	Ethanol	catalase	MESH:D000431	24248(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|stimulation stimulation|dep|effect effect|acl|prevented prevented|nmod|inhibition inhibition|amod|END_ENTITY	Ethanol injected into the hypothalamic arcuate nucleus induces behavioral stimulation in rats : an effect prevented by catalase inhibition and naltrexone .
3426685	0	Ethanol	0,7	catalase	126,134	Ethanol	catalase	MESH:D000431	847	Chemical	Gene	metabolism|amod|START_ENTITY mediated|nsubjpass|metabolism mediated|advcl|system system|nmod|END_ENTITY	Ethanol metabolism in alcohol dehydrogenase deficient deermice is mediated by the microsomal ethanol oxidizing system , not by catalase .
12242633	0	Ethanol	0,7	cob	29,32	Ethanol	cob	MESH:D000431	4055802(Tax:381124)	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Ethanol production from corn cob hydrolysates by Escherichia_coli_KO11 .
21487655	0	Ethanol	0,7	corticotropin-releasing_factor	86,116	Ethanol	corticotropin-releasing factor	MESH:D000431	12918(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|drinking drinking|nmod|type type|compound|END_ENTITY	Ethanol concentration-dependent effects and the role of stress on ethanol drinking in corticotropin-releasing_factor type 1 and double type 1 and 2 receptor knockout mice .
26220687	0	Ethanol	0,7	cyclooxygenase-2	33,49	Ethanol	cyclooxygenase-2	MESH:D000431	5743	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Ethanol enhances arsenic-induced cyclooxygenase-2 expression via both NFAT and NF-kB signalings in colorectal_cancer cells .
17084997	0	Ethanol	0,7	cytochrome_P450	60,75	Ethanol	cytochrome P450	MESH:D000431	4051	Chemical	Gene	oxidation|amod|START_ENTITY oxidation|nmod|isoforms isoforms|amod|END_ENTITY	Ethanol oxidation into acetaldehyde by 16 recombinant human cytochrome_P450 isoforms : role of CYP2C isoforms in human liver microsomes .
7595552	0	Ethanol	0,7	cytochrome_P4502E1	18,36	Ethanol	cytochrome P4502E1	MESH:D000431	1571	Chemical	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	Ethanol increases cytochrome_P4502E1 and induces oxidative stress in astrocytes .
8074729	0	Ethanol	0,7	cytochrome_P4502E1	48,66	Ethanol	cytochrome P4502E1	MESH:D000431	1571	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|content content|nmod|END_ENTITY	Ethanol increases content and activity of human cytochrome_P4502E1 in a transduced HepG2 cell line .
8798623	0	Ethanol	0,7	cytochrome_P4502E1	71,89	Ethanol	cytochrome P4502E1	MESH:D000431	1571	Chemical	Gene	START_ENTITY|nmod|line line|acl|expressing expressing|dobj|END_ENTITY	Ethanol cytotoxicity to a transfected HepG2 cell line expressing human cytochrome_P4502E1 .
10770928	0	Ethanol	0,7	cytochrome_P450_2E1	114,133	Ethanol	cytochrome P450 2E1	MESH:D000431	25086(Tax:10116)	Chemical	Gene	increase|amod|START_ENTITY collagen|nsubj|increase collagen|xcomp|overexpressing overexpressing|dobj|END_ENTITY	Ethanol and arachidonic_acid increase alpha 2 -LRB- I -RRB- collagen expression in rat hepatic stellate cells overexpressing cytochrome_P450_2E1 .
16337197	0	Ethanol	0,7	cytochrome_P450_2E1	32,51	Ethanol	cytochrome P450 2E1	MESH:D000431	13106(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Ethanol increases mitochondrial cytochrome_P450_2E1 in mouse liver and rat hepatocytes .
21999510	0	Ethanol	0,7	cytochrome_P450_2E1	29,48	Ethanol	cytochrome P450 2E1	MESH:D000431	25086(Tax:10116)	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Ethanol induced induction of cytochrome_P450_2E1 and activation of mitogen activated protein kinases in peripheral blood lymphocytes .
8264548	0	Ethanol	0,7	delta-opioid_receptor	18,39	Ethanol	delta-opioid receptor	MESH:D000431	18386(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Ethanol increases delta-opioid_receptor gene expression in neuronal cell lines .
8750843	0	Ethanol	0,7	diazepam_binding_inhibitor	19,45	Ethanol	diazepam binding inhibitor	MESH:D000431	1622	Chemical	Gene	stimulates|amod|START_ENTITY END_ENTITY|nsubj|stimulates	Ethanol stimulates diazepam_binding_inhibitor -LRB- DBI -RRB- mRNA expression in primary cultured neurons .
11739621	0	Ethanol	0,7	dopamine_transporter	46,66	Ethanol	dopamine transporter	MESH:D000431	6531	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|function function|nmod|END_ENTITY	Ethanol potentiates the function of the human dopamine_transporter expressed in Xenopus oocytes .
7685006	0	Ethanol	0,7	endothelial_nitric_oxide_synthase	21,54	Ethanol	endothelial nitric oxide synthase	MESH:D000431	287024(Tax:9913)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|response response|amod|END_ENTITY	Ethanol enhances the endothelial_nitric_oxide_synthase response to agonists .
23797280	0	Ethanol	0,7	endothelin-1	30,42	Ethanol	endothelin-1	MESH:D000431	24323(Tax:10116)	Chemical	Gene	consumption|amod|START_ENTITY increases|nsubj|consumption increases|dobj|expression expression|amod|END_ENTITY	Ethanol consumption increases endothelin-1 expression and reactivity in the rat cavernosal smooth muscle .
12818715	0	Ethanol	0,7	galanin	25,32	Ethanol	galanin	MESH:D000431	29141(Tax:10116)	Chemical	Gene	mRNA|amod|START_ENTITY mRNA|compound|END_ENTITY	Ethanol intake increases galanin mRNA in the hypothalamus and withdrawal decreases it .
20382889	0	Ethanol	0,7	glucocorticoid-induced_leucine_zipper	20,57	Ethanol	glucocorticoid-induced leucine zipper	MESH:D000431	1831	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Ethanol upregulates glucocorticoid-induced_leucine_zipper expression and modulates cellular inflammatory responses in lung epithelial cells .
6365088	0	Ethanol	0,7	glucose_6-phosphate_dehydrogenase	65,98	Ethanol	glucose 6-phosphate dehydrogenase	MESH:D000431	24377(Tax:10116)	Chemical	Gene	modulation|amod|START_ENTITY modulation|nmod|regulation regulation|nmod|activity activity|amod|END_ENTITY	Ethanol modulation of the hormonal and nutritional regulation of glucose_6-phosphate_dehydrogenase activity in primary cultures of rat hepatocytes .
18336632	0	Ethanol	0,7	hPepT1	83,89	Ethanol	hPepT1	MESH:D000431	6564	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	Ethanol inhibits functional activity of the human intestinal dipeptide transporter hPepT1 expressed in Xenopus oocytes .
11173986	0	Ethanol	0,7	iNOS	34,38	Ethanol	iNOS	MESH:D000431	4843	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Ethanol inhibits cytokine-induced iNOS and sPLA2 in immortalized astrocytes : evidence for posttranscriptional site of ethanol action .
19860806	0	Ethanol	0,7	iNOS	20,24	Ethanol	iNOS	MESH:D000431	24599(Tax:10116)	Chemical	Gene	upregulates|amod|START_ENTITY END_ENTITY|nsubj|upregulates	Ethanol upregulates iNOS expression in colon through activation of nuclear factor-kappa B in rats .
26500219	0	Ethanol	0,7	inducible_nitric_oxide_synthase	52,83	Ethanol	inducible nitric oxide synthase	MESH:D000431	24599(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|vasorelaxation vasorelaxation|nmod|inhibition inhibition|nmod|END_ENTITY	Ethanol attenuates vasorelaxation via inhibition of inducible_nitric_oxide_synthase in rat artery exposed to interleukin-1b .
7538755	0	Ethanol	0,7	inducible_nitric_oxide_synthase	50,81	Ethanol	inducible nitric oxide synthase	MESH:D000431	24599(Tax:10116)	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|expression expression|compound|END_ENTITY	Ethanol potentiates interleukin-1_beta-stimulated inducible_nitric_oxide_synthase expression in cultured vascular smooth muscle cells .
12148691	0	Ethanol	0,7	insulin	24,31	Ethanol	insulin	MESH:D000431	3630	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|secretion secretion|compound|END_ENTITY	Ethanol decreases basal insulin secretion from HIT-T15 cells .
1583907	0	Ethanol	0,7	interferon-gamma	17,33	Ethanol	interferon-gamma	MESH:D000431	3458	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|amod|END_ENTITY	Ethanol inhibits interferon-gamma secretion by human peripheral lymphocytes .
9402932	0	Ethanol	0,7	interleukin-6	22,35	Ethanol	interleukin-6	MESH:D000431	3569	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|promoter promoter|amod|END_ENTITY	Ethanol activates the interleukin-6 promoter in a human bone marrow stromal cell line .
6755122	0	Ethanol	0,7	luteinizing_hormone-releasing_hormone	49,86	Ethanol	luteinizing hormone-releasing hormone	MESH:D000431	25194(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|nmod|END_ENTITY	Ethanol inhibits the naloxone-induced release of luteinizing_hormone-releasing_hormone from the hypothalamus of the male rat .
8413822	0	Ethanol	0,7	luteinizing_hormone_releasing_hormone	62,99	Ethanol	luteinizing hormone releasing hormone	MESH:D000431	25194(Tax:10116)	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|secretion secretion|nmod|END_ENTITY	Ethanol alters N-methyl-DL-aspartic_acid-induced secretion of luteinizing_hormone_releasing_hormone and the onset of puberty in the female rat .
23978445	0	Ethanol	0,7	matrix_metalloproteinase-12	18,45	Ethanol	matrix metalloproteinase-12	MESH:D000431	17381(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Ethanol increases matrix_metalloproteinase-12 expression via NADPH oxidase-dependent ROS production in macrophages .
16465419	0	Ethanol	0,7	matrix_metalloproteinases_2_and_9	36,69	Ethanol	matrix metalloproteinases 2 and 9	MESH:D000431	4313;4318	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|nmod|END_ENTITY	Ethanol stimulates the secretion of matrix_metalloproteinases_2_and_9 in MCF-7 human breast_cancer cells .
10761214	0	Ethanol	1,8	monoamine_oxidase_type_B	27,51	Ethanol	monoamine oxidase type B	MESH:D000431	4129	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	-LSB- Ethanol inhibits platelet monoamine_oxidase_type_B activity in patients with alcoholism -RSB- .
15908470	0	Ethanol	0,7	monocyte_chemotactic_protein-1	17,47	Ethanol	monocyte chemotactic protein-1	MESH:D000431	6347	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Ethanol inhibits monocyte_chemotactic_protein-1 expression in interleukin-1 -LCB- beta -RCB- - activated human endothelial cells .
3716884	0	Ethanol	0,7	myoglobin	16,25	Ethanol	myoglobin	MESH:D000431	4151	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|release release|compound|END_ENTITY	Ethanol reduces myoglobin release during isokinetic muscle exercise .
26622576	0	Ethanol	0,7	nerve_growth_factor_receptor	36,64	Ethanol	nerve growth factor receptor	MESH:D000431	4804	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|upregulation upregulation|nmod|CD271 CD271|compound|END_ENTITY	Ethanol induces upregulation of the nerve_growth_factor_receptor CD271 in human melanoma cells via nuclear factor-kB activation .
9267539	0	Ethanol	0,7	nerve_growth_factor_receptor	34,62	Ethanol	nerve growth factor receptor	MESH:D000431	24596(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|nmod|END_ENTITY	Ethanol reduces expression of the nerve_growth_factor_receptor , but not nerve_growth_factor protein levels in the neonatal rat cerebellum .
21985251	0	Ethanol	0,7	p190RhoGAP	18,28	Ethanol	p190RhoGAP	MESH:D000431	306400(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|activity activity|amod|END_ENTITY	Ethanol increases p190RhoGAP activity , leading to actin cytoskeleton rearrangements .
11329487	0	Ethanol	0,7	p21	32,35	Ethanol	p21	MESH:D000431	644914	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Ethanol decreases expression of p21 and increases hyperphosphorylated pRb in cell lines of squamous_cell_carcinomas of the head and neck .
16226824	0	Ethanol	0,7	p38	16,19	Ethanol	p38	MESH:D000431	81649(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|activation activation|amod|END_ENTITY	Ethanol reduces p38 kinase activation and cyclin_D1 protein expression after partial hepatectomy in rats .
16820725	0	Ethanol	0,7	pituitary_adenylate_cyclase_activating_polypeptide	36,86	Ethanol	pituitary adenylate cyclase activating polypeptide	MESH:D000431	24166(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|nmod|END_ENTITY	Ethanol decreases the expression of pituitary_adenylate_cyclase_activating_polypeptide in rat testes .
12351938	0	Ethanol	0,7	prolactin	49,58	Ethanol	prolactin	MESH:D000431	24683(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|release release|compound|END_ENTITY	Ethanol induces hyperprolactinemia by increasing prolactin release and lactotrope growth in female rats .
17067358	0	Ethanol	0,7	proopiomelanocortin	40,59	Ethanol	proopiomelanocortin	MESH:D000431	24664(Tax:10116)	Chemical	Gene	suppression|amod|START_ENTITY suppression|nmod|level level|compound|END_ENTITY	Ethanol suppression of the hypothalamic proopiomelanocortin level and the splenic NK cell cytolytic activity is associated with a reduction in the expression of proinflammatory cytokines but not anti-inflammatory cytokines in neuroendocrine and immune cells .
23408117	0	Ethanol	0,7	protein_kinase_A	22,38	Ethanol	protein kinase A	MESH:D000431	25636(Tax:10116)	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Ethanol activation of protein_kinase_A regulates GABAA a1 receptor function and trafficking in cultured cerebral cortical neurons .
1665014	0	Ethanol	0,7	protein_kinase_C	57,73	Ethanol	protein kinase C	MESH:D000431	112476	Chemical	Gene	has|nsubj|START_ENTITY has|dobj|phosphorylation phosphorylation|amod|- -|amod|END_ENTITY	Ethanol has no effect on cAMP-dependent protein kinase - , protein_kinase_C - , or Ca -LRB- 2 + -RRB- - calmodulin-dependent protein kinase II-stimulated phosphorylation of highly purified substrates in vitro .
10835432	0	Ethanol	0,7	protein_kinase_C_delta	46,68	Ethanol	protein kinase C delta	MESH:D000431	170538(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Ethanol regulates calcium channel subunits by protein_kinase_C_delta - dependent and - independent mechanisms .
16084468	0	Ethanol	0,7	protein_kinase_C_epsilon	86,110	Ethanol	protein kinase C epsilon	MESH:D000431	29340(Tax:10116)	Chemical	Gene	allodynia|amod|START_ENTITY allodynia|dep|regulation regulation|nmod|isoenzymes isoenzymes|compound|END_ENTITY	Ethanol withdrawal-associated allodynia and hyperalgesia : age-dependent regulation by protein_kinase_C_epsilon and gamma isoenzymes .
21212859	0	Ethanol	0,7	proteolipid_protein	48,67	Ethanol	proteolipid protein	MESH:D000431	24943(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Ethanol down regulates the expression of myelin proteolipid_protein in the rat hippocampus .
23991167	0	Ethanol	0,7	serum_glucocorticoid_kinase_1	22,51	Ethanol	serum glucocorticoid kinase 1	MESH:D000431	20393(Tax:10090)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Ethanol regulation of serum_glucocorticoid_kinase_1 expression in DBA2/J mouse prefrontal cortex .
12892842	0	Ethanol	0,7	steroidogenic_acute_regulatory_protein	24,62	Ethanol	steroidogenic acute regulatory protein	MESH:D000431	25557(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Ethanol rapidly induces steroidogenic_acute_regulatory_protein expression and translocation in rat adrenal gland .
9660311	0	Ethanol	0,7	t-PA	38,42	Ethanol	t-PA	MESH:D000431	5327	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	Ethanol transcriptionally upregulates t-PA and u-PA gene expression in cultured human endothelial cells .
8464328	0	Ethanol	0,7	tumor_necrosis_factor	22,43	Ethanol	tumor necrosis factor	MESH:D000431	21926(Tax:10090)	Chemical	Gene	modulation|amod|START_ENTITY modulation|nmod|END_ENTITY	Ethanol modulation of tumor_necrosis_factor and gamma interferon production by murine splenocytes and macrophages .
10656197	0	Ethanol	0,7	tumor_necrosis_factor-alpha	43,70	Ethanol	tumor necrosis factor-alpha	MESH:D000431	24835(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|effect effect|nmod|END_ENTITY	Ethanol increases the neurotoxic effect of tumor_necrosis_factor-alpha in cultured rat astrocytes .
10760953	0	Ethanol	0,7	tumor_necrosis_factor-alpha	32,59	Ethanol	tumor necrosis factor-alpha	MESH:D000431	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|prolactin prolactin|dep|END_ENTITY	Ethanol inhibits prolactin - and tumor_necrosis_factor-alpha - , but not gamma interferon-induced expression of intercellular_adhesion_molecule-1 in human astrocytoma cells .
10796891	0	Ethanol	0,7	tumor_necrosis_factor-alpha	20,47	Ethanol	tumor necrosis factor-alpha	MESH:D000431	24835(Tax:10116)	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|cytotoxicity cytotoxicity|amod|END_ENTITY	Ethanol potentiates tumor_necrosis_factor-alpha cytotoxicity in hepatoma cells and primary rat hepatocytes by promoting induction of the mitochondrial permeability transition .
15353169	0	Ethanol	0,7	tumor_necrosis_factor-alpha	18,45	Ethanol	tumor necrosis factor-alpha	MESH:D000431	7124	Chemical	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	Ethanol increases tumor_necrosis_factor-alpha receptor-1 -LRB- TNF-R1 -RRB- levels in hepatic , intestinal , and cardiac cells .
7783663	0	Ethanol	0,7	xanthine_dehydrogenase	13,35	Ethanol	xanthine dehydrogenase	MESH:D000431	7498	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|amod|END_ENTITY	Ethanol as a xanthine_dehydrogenase inhibitor .
16618207	0	Ethanolamine	0,12	epidermal_growth_factor_receptor	45,77	Ethanolamine	epidermal growth factor receptor	MESH:D019856	24329(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	Ethanolamine modulates DNA synthesis through epidermal_growth_factor_receptor in rat primary hepatocytes .
22210352	0	Ethaselen	0,9	thioredoxin_reductase_1	30,53	Ethaselen	thioredoxin reductase 1	MESH:C478160	7296	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Ethaselen : a potent mammalian thioredoxin_reductase_1 inhibitor and novel organoselenium anticancer agent .
12231879	0	Ethephon	128,136	Ornithine_Decarboxylase	20,43	Ethephon	Ornithine Decarboxylase	MESH:C005073	544209(Tax:4081)	Chemical	Gene	Correlation|nmod|START_ENTITY Correlation|nmod|END_ENTITY	Correlation between Ornithine_Decarboxylase and Putrescine in Tomato Plants Infected by Citrus Exocortis Viroid or Treated with Ethephon .
16839531	0	Ethidium_bromide	0,16	acetylcholinesterase	36,56	Ethidium bromide	acetylcholinesterase	MESH:D004996	83817(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	Ethidium_bromide inhibits rat brain acetylcholinesterase activity in vitro .
23867992	0	Ethionine	0,9	LPA_receptor-3	49,63	Ethionine	LPA receptor-3	MESH:D005001	66025(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Ethionine regulates cell motile activity through LPA_receptor-3 in liver epithelial WB-F344 cells .
197084	0	Ethionine	0,9	ribosomal_protein_S6	37,57	Ethionine	ribosomal protein S6	MESH:D005001	29304(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Ethionine and the phosphorylation of ribosomal_protein_S6 .
16041399	0	Ethyl_caffeate	0,14	NF-kappaB	26,35	Ethyl caffeate	NF-kappaB	MESH:C032773	18033(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|activation activation|amod|END_ENTITY	Ethyl_caffeate suppresses NF-kappaB activation and its downstream inflammatory mediators , iNOS , COX-2 , and PGE2 in vitro or in mouse skin .
15345140	0	Ethyl_ferulate	0,14	HO-1	49,53	Ethyl ferulate	HO-1	MESH:C099085	24451(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Ethyl_ferulate , a lipophilic polyphenol , induces HO-1 and protects rat neurons against oxidative stress .
24018486	0	Ethyl_gallate	0,13	Nrf2	51,55	Ethyl gallate	Nrf2	MESH:C048734	4780	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|nmod|END_ENTITY	Ethyl_gallate attenuates acute_lung_injury through Nrf2 signaling .
8605290	0	Ethyl_octylphosphonofluoridate	0,30	neuropathy_target_esterase	68,94	Ethyl octylphosphonofluoridate	neuropathy target esterase	MESH:C100419	10908	Chemical	Gene	START_ENTITY|dep|inhibitors inhibitors|nmod|END_ENTITY	Ethyl_octylphosphonofluoridate and analogs : optimized inhibitors of neuropathy_target_esterase .
19454652	0	Ethyl_pyruvate	0,14	HMGB1	25,30	Ethyl pyruvate	HMGB1	MESH:C046522	15289(Tax:10090)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|release release|compound|END_ENTITY	Ethyl_pyruvate decreases HMGB1 release and ameliorates murine colitis .
24246904	0	Ethyl_pyruvate	0,14	HMGB1	24,29	Ethyl pyruvate	HMGB1	MESH:C046522	3146	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Ethyl_pyruvate inhibits HMGB1 phosphorylation and secretion in activated microglia and in the postischemic brain .
20338685	0	Ethyl_pyruvate	0,14	hypoxia-inducible_factor_1_alpha	26,58	Ethyl pyruvate	hypoxia-inducible factor 1 alpha	MESH:C046522	3091	Chemical	Gene	stabilizes|nsubj|START_ENTITY stabilizes|xcomp|END_ENTITY	Ethyl_pyruvate stabilizes hypoxia-inducible_factor_1_alpha via stimulation of the TCA cycle .
26410794	0	Ethylene	26,34	ACS4	102,106	Ethylene	ACS4	MESH:C036216	816812(Tax:3702)	Chemical	Gene	Production|compound|START_ENTITY Production|nmod|END_ENTITY	Abscisic_Acid Antagonizes Ethylene Production through the ABI4-Mediated Transcriptional Repression of ACS4 and ACS8 in Arabidopsis .
26109425	0	Ethylene	0,8	AUX1	65,69	Ethylene	AUX1	MESH:C036216	818390(Tax:3702)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Ethylene inhibits root elongation during alkaline stress through AUX1 and associated changes in auxin accumulation .
7569898	0	Ethylene	0,8	ERS	48,51	Ethylene	ERS	MESH:C036216	836526(Tax:3702)	Chemical	Gene	conferred|nsubj|START_ENTITY conferred|nmod|gene gene|compound|END_ENTITY	Ethylene insensitivity conferred by Arabidopsis ERS gene .
10938361	0	Ethylene	0,8	ERS1	27,31	Ethylene	ERS1	MESH:C036216	818693(Tax:3702)	Chemical	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	Ethylene perception by the ERS1 protein in Arabidopsis .
26160962	0	Ethylene	75,83	ETHYLENE_RESPONSE1	56,74	Ethylene	ETHYLENE RESPONSE1	MESH:C036216	842951(Tax:3702)	Chemical	Gene	Receptor|compound|START_ENTITY Receptor|compound|END_ENTITY	Identification of Regions in the Receiver Domain of the ETHYLENE_RESPONSE1 Ethylene Receptor of Arabidopsis Important for Functional Divergence .
17071649	0	Ethylene	0,8	ETR1	56,60	Ethylene	ETR1	MESH:C036216	842951(Tax:3702)	Chemical	Gene	stimulates|amod|START_ENTITY nutations|nsubj|stimulates nutations|ccomp|dependent dependent|nmod|receptor receptor|compound|END_ENTITY	Ethylene stimulates nutations that are dependent on the ETR1 receptor .
19825547	0	Ethylene	0,8	ETR1	90,94	Ethylene	ETR1	MESH:C036216	842951(Tax:3702)	Chemical	Gene	controls|nsubj|START_ENTITY controls|dobj|autophosphorylation autophosphorylation|nmod|domain domain|nmod|END_ENTITY	Ethylene controls autophosphorylation of the histidine kinase domain in ethylene receptor ETR1 .
22145846	0	Ethylene	0,8	EXPA5	30,35	Ethylene	EXPA5	MESH:C036216	822543(Tax:3702)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nummod|END_ENTITY	Ethylene negatively regulates EXPA5 expression in Arabidopsis_thaliana .
22692214	0	Ethylene	97,105	etr1	21,25	Ethylene	etr1	MESH:C036216	842951(Tax:3702)	Chemical	Gene	Responses|compound|START_ENTITY Inhibition|nmod|Responses Role|nmod|Inhibition Sufficient|dobj|Role Sufficient|nsubj|receptor receptor|appos|END_ENTITY	ethylene receptor 1 -LRB- etr1 -RRB- Is Sufficient and Has the Predominant Role in Mediating Inhibition of Ethylene Responses by Silver in Arabidopsis_thaliana .
3816612	0	Ethylene_glycol_monomethyl_ether	0,32	ornithine_decarboxylase	60,83	Ethylene glycol monomethyl ether	ornithine decarboxylase	MESH:C005219	24609(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Ethylene_glycol_monomethyl_ether -LRB- EGME -RRB- inhibits rat embryo ornithine_decarboxylase -LRB- ODC -RRB- activity .
20473363	0	Ethynyl	0,7	Cytochrome_P450	41,56	Ethynyl	Cytochrome P450	CHEBI:30085	4051	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|nmod|END_ENTITY	Ethynyl and Propynylpyrene Inhibitors of Cytochrome_P450 .
16554369	0	Ethynylestradiol	0,16	MRP3	64,68	Ethynylestradiol	MRP3	MESH:D004997	140668(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Ethynylestradiol increases expression and activity of rat liver MRP3 .
26510670	0	Ethynylphenyl_carbonates	0,24	acetylcholinesterase	55,75	Ethynylphenyl carbonates	acetylcholinesterase	null	43	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Ethynylphenyl_carbonates and carbamates as dual-action acetylcholinesterase inhibitors and anti-inflammatory agents .
10599049	0	Etidronate	0,10	IL-6	38,42	Etidronate	IL-6	MESH:D012968	3569	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|nmod|END_ENTITY	Etidronate inhibits the production of IL-6 by osteoblast-like cells .
16391837	0	Etodolac	0,8	cyclooxygenase-2	22,38	Etodolac	cyclooxygenase-2	MESH:D017308	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Etodolac , a selective cyclooxygenase-2 inhibitor , inhibits liver metastasis of colorectal_cancer cells via the suppression of MMP-9 activity .
6604560	0	Etomidate	0,9	prolactin	19,28	Etomidate	prolactin	MESH:D005045	24683(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|compound|END_ENTITY	Etomidate inhibits prolactin release but not through a dopaminergic mechanism .
18431490	0	Etoposide	0,9	AMPK	65,69	Etoposide	AMPK	MESH:D005047	5563	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|compound|END_ENTITY	Etoposide induces ATM-dependent mitochondrial biogenesis through AMPK activation .
8080673	0	Etoposide	0,9	EAP	38,41	Etoposide	EAP	MESH:D005047	2028	Chemical	Gene	treatment|compound|START_ENTITY treatment|compound|END_ENTITY	Etoposide , doxorubicin and cisplatin -LRB- EAP -RRB- treatment in advanced gastric_carcinoma : a multicentre study of the Italian Trials in Medical Oncology -LRB- I.T.M.O. -RRB- Group .
19956877	0	Etoposide	0,9	androgen_receptor	45,62	Etoposide	androgen receptor	MESH:D005047	367	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Etoposide induces growth_arrest and disrupts androgen_receptor signaling in prostate_cancer cells .
24436715	11	Etoposide	1666,1675	caspase-8	1725,1734	Etoposide	caspase-9	MESH:D005047	842	Chemical	Gene	START_ENTITY|dep|apoptosis apoptosis|acl|END_ENTITY	In the human NP cells , NCCM inhibits Etoposide - mediated apoptosis via suppression of activated caspase-8 , caspase-9 , and mainly caspase-3 / 7 .
15314975	0	Etoposide	121,130	p21	14,17	Etoposide	p21	MESH:D005047	1026	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|proteins proteins|amod|END_ENTITY	Expression of p21 and bcl-2 proteins in paraffin-embedded preparations of non-small_cell_lung_cancer in stage IIIA after Etoposide and Cisplatin induced chemotherapy .
15827069	0	Etoricoxib	0,10	COX-2	31,36	Etoricoxib	COX-2	MESH:C422649	5743	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Etoricoxib : a highly selective COX-2 inhibitor .
11160644	0	Etoricoxib	0,10	cyclooxygenase-2	100,116	Etoricoxib	cyclooxygenase-2	MESH:C422649	5743	Chemical	Gene	START_ENTITY|dep|profile profile|acl:relcl|inhibit inhibit|xcomp|END_ENTITY	Etoricoxib -LRB- MK-0663 -RRB- : preclinical profile and comparison with other agents that selectively inhibit cyclooxygenase-2 .
25773735	0	Eucalyptol	0,10	matrix_metalloproteinase-9	22,48	Eucalyptol	matrix metalloproteinase-9	MESH:C010087	17395(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Eucalyptol suppresses matrix_metalloproteinase-9 expression through an extracellular signal-regulated kinase-dependent nuclear factor-kappa B pathway to exert anti-inflammatory effects in an acute_lung_inflammation model .
17889685	0	Eugenol	0,7	cyclooxygenase-2	18,34	Eugenol	cyclooxygenase-2	MESH:D005054	5743	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	Eugenol modulates cyclooxygenase-2 expression through the activation of nuclear_factor_kappa_B in human osteoblasts .
17889685	0	Eugenol	0,7	nuclear_factor_kappa_B	72,94	Eugenol	nuclear factor kappa B	MESH:D005054	4790	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|nmod|activation activation|nmod|END_ENTITY	Eugenol modulates cyclooxygenase-2 expression through the activation of nuclear_factor_kappa_B in human osteoblasts .
23118554	0	Eupatilin	25,34	5-Lipoxygenase	86,100	Eupatilin	5-Lipoxygenase	MESH:C045325	240	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	The Protective Effect of Eupatilin against Hydrogen_Peroxide-Induced Injury Involving 5-Lipoxygenase in Feline Esophageal Epithelial Cells .
26947172	0	Everolimus	17,27	HER2	83,87	Everolimus	HER2	MESH:C107135	2064	Chemical	Gene	Monotherapy|compound|START_ENTITY Effectiveness|nmod|Monotherapy mBC|nsubj|Effectiveness mBC|nmod|+ +|dep|END_ENTITY	Effectiveness of Everolimus Versus Endocrine Monotherapy or Chemotherapy Among HR + / HER2 - mBC Patients With Multiple Metastatic Sites .
19496707	0	Everolimus	0,10	mTOR	24,28	Everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Everolimus -LRB- RAD001 -RRB- : an mTOR inhibitor for the treatment of metastatic_renal_cell_carcinoma .
19643477	0	Everolimus	23,33	mTOR	0,4	Everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	RAD001|appos|START_ENTITY RAD001|compound|END_ENTITY	mTOR inhibitor RAD001 -LRB- Everolimus -RRB- enhances the effects of imatinib in chronic_myeloid_leukemia by raising the nuclear expression of c-ABL protein .
20569486	0	Everolimus	26,36	mTOR	4,8	Everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	decreases|nsubj|START_ENTITY kinase|ccomp|decreases kinase|nsubj|END_ENTITY	The mTOR kinase inhibitor Everolimus decreases S6 kinase phosphorylation but fails to reduce mutant huntingtin levels in brain and is not neuroprotective in the R6/2 mouse model of Huntington 's _ disease .
21916571	0	Everolimus	0,10	mTOR	15,19	Everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Everolimus : an mTOR inhibitor for the treatment of tuberous_sclerosis .
24738962	0	Everolimus	53,63	mTOR	37,41	Everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Renal function preservation with the mTOR inhibitor , Everolimus , after lung transplant .
25580277	0	Everolimus	153,163	mTOR	42,46	Everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	Results|nmod|START_ENTITY Associated|dep|Results Associated|nmod|Inhibitors Inhibitors|compound|END_ENTITY	Interstitial_Lung_Disease Associated with mTOR Inhibitors in Solid Organ Transplant Recipients : Results from a Large Phase III Clinical Trial Program of Everolimus and Review of the Literature .
25682485	0	Everolimus	22,32	mTOR	7,11	Everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	START_ENTITY|dep|Use Use|nmod|END_ENTITY	Use of mTOR Inhibitor Everolimus in Three Neonates for Treatment of Tumor Lesions Associated With Tuberous_Sclerosis Complex .
25724525	0	Everolimus	41,51	mTOR	26,30	Everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	Phase|dep|START_ENTITY Phase|dep|Study Study|nmod|END_ENTITY	A Phase I/II Study of the mTOR Inhibitor Everolimus in Combination with HyperCVAD Chemotherapy in Patients with Relapsed / Refractory Acute_Lymphoblastic_Leukemia .
26148118	0	Everolimus	66,76	mTOR	51,55	Everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Potentiation Potentiation|nmod|Responses Responses|nmod|Inhibitor Inhibitor|compound|END_ENTITY	Potentiation of Growth Inhibitory Responses of the mTOR Inhibitor Everolimus by Dual mTORC1/2 Inhibitors in Cultured Breast_Cancer Cell Lines .
26172931	0	Everolimus	0,10	mTOR	15,19	Everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Everolimus , an mTOR pathway inhibitor , is highly successful on ovarian_hyperstimulation_syndrome by reducing ovarian weight and progesterone levels : a preclinical experimental randomized controlled study .
26821351	0	Everolimus	30,40	mTOR	14,18	Everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	Complex|nmod|START_ENTITY Complex|csubj|Targeting Targeting|dobj|END_ENTITY	Targeting the mTOR Complex by Everolimus in NRAS Mutant Neuroblastoma .
18245553	0	Everolimus	76,86	mammalian_target_of_rapamycin	28,57	Everolimus	mammalian target of rapamycin	MESH:C107135	2475	Chemical	Gene	RAD001|appos|START_ENTITY RAD001|compound|END_ENTITY	Antiangiogenic therapy with mammalian_target_of_rapamycin inhibitor RAD001 -LRB- Everolimus -RRB- increases radiosensitivity in solid cancer .
21177421	0	Everolimus	0,10	mammalian_target_of_rapamycin	18,47	Everolimus	mammalian target of rapamycin	MESH:C107135	2475	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Everolimus : a new mammalian_target_of_rapamycin inhibitor for the treatment of advanced_renal_cell_carcinoma .
23032719	0	Evodiamine	0,10	STAT3	20,25	Evodiamine	STAT3	MESH:C049639	6774	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Evodiamine inhibits STAT3 signaling by inducing phosphatase shatterproof 1 in hepatocellular_carcinoma cells .
25333675	0	Evodiamine	0,10	TRAIL	48,53	Evodiamine	TRAIL	MESH:C049639	8743	Chemical	Gene	sensitizes|nsubj|START_ENTITY sensitizes|nmod|END_ENTITY	Evodiamine sensitizes U87 glioblastoma cells to TRAIL via the death receptor pathway .
15305207	0	Evodiamine	0,10	TRPV1	62,67	Evodiamine	TRPV1	MESH:C049639	83810(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|agonist agonist|nmod|END_ENTITY	Evodiamine functions as an agonist for the vanilloid receptor TRPV1 .
22942745	0	Evodiamine	27,37	TRPV1	64,69	Evodiamine	TRPV1	MESH:C049639	7442	Chemical	Gene	Prediction|nmod|START_ENTITY Binding|dobj|Prediction Binding|nmod|END_ENTITY	Binding Mode Prediction of Evodiamine within Vanilloid Receptor TRPV1 .
21246637	0	Evodiamine	0,10	activator_protein_1	65,84	Evodiamine	activator protein 1	MESH:C049639	3726	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|transactivation transactivation|compound|END_ENTITY	Evodiamine inhibits 12-O-tetradecanoylphorbol-13-acetate-induced activator_protein_1 transactivation and cell transformation in human hepatocytes .
26633898	0	Evogliptin	22,32	Dipeptidyl_Peptidase_4	42,64	Evogliptin	Dipeptidyl Peptidase 4	null	13482(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|Inhibitor Inhibitor|compound|END_ENTITY	Beneficial Effects of Evogliptin , a Novel Dipeptidyl_Peptidase_4 Inhibitor , on Adiposity with Increased Ppargc1a in White Adipose Tissue in Obese Mice .
26525891	7	Ex527	1079,1084	SIRT1	1059,1064	Ex527	SIRT1	MESH:C550547	309757(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Moreover , pharmacological SIRT1 inhibition by Ex527 induced HMGB1 translocation and release , whereas SIRT1 activation by resveratrol or SalB reversed this trend .
17027257	0	Exemestane	75,85	COX-2	95,100	Exemestane	COX-2	MESH:C056516	5743	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|compound|END_ENTITY	A feasibility study of the efficacy and tolerability of the combination of Exemestane with the COX-2 inhibitor Celecoxib in post-menopausal patients with advanced_breast_cancer .
26386291	0	Exenatide	0,9	TNF-a	18,23	Exenatide	TNF-a	MESH:C074031	24835(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|amod|END_ENTITY	Exenatide reduces TNF-a expression and improves hippocampal neuron numbers and memory in streptozotocin treated rats .
16782054	0	Exenatide	0,9	thioredoxin-interacting_protein	53,84	Exenatide	thioredoxin-interacting protein	MESH:C074031	56338(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Exenatide inhibits beta-cell apoptosis by decreasing thioredoxin-interacting_protein .
17165752	0	Exiguamine_A	0,12	IDO	46,49	Exiguamine A	IDO	MESH:C516830	3620	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|appos|END_ENTITY	Exiguamine_A , an indoleamine-2 ,3 - dioxygenase -LRB- IDO -RRB- inhibitor isolated from the marine sponge Neopetrosia exigua .
27051238	0	Ezetimibe	39,48	CD36	92,96	Ezetimibe	CD36	MESH:C108606	29184(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	The Glucotoxicity Protecting Effect of Ezetimibe in Pancreatic Beta Cells via Inhibition of CD36 .
25704082	0	Ezetimibe	0,9	Glucagon-Like_Peptide_1	32,55	Ezetimibe	Glucagon-Like Peptide 1	MESH:C108606	2641	Chemical	Gene	Secretion|compound|START_ENTITY Secretion|compound|END_ENTITY	Ezetimibe Stimulates Intestinal Glucagon-Like_Peptide_1 Secretion Via the MEK/ERK Pathway Rather Than Dipeptidyl_Peptidase_4 Inhibition .
20875380	0	Ezetimibe	0,9	HDL3	46,50	Ezetimibe	HDL3	MESH:C108606	53369	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|nmod|END_ENTITY	Ezetimibe decreases serum_amyloid_A levels in HDL3 in hemodialysis patients .
18837641	0	Ezetimibe	0,9	LDL-C	35,40	Ezetimibe	LDL-C	MESH:C108606	22796	Chemical	Gene	mg|amod|START_ENTITY mg|acl|lowering lowering|dobj|END_ENTITY	Ezetimibe 5 and 10 mg for lowering LDL-C : potential billion-dollar savings with improved tolerability .
20673929	0	Ezetimibe	0,9	SREBP-1c	20,28	Ezetimibe	SREBP-1c	MESH:C108606	20787(Tax:10090)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|compound|END_ENTITY	Ezetimibe decreases SREBP-1c expression in liver and reverses hepatic insulin resistance in mice fed a high-fat diet .
19777283	0	Ezetimibe	0,9	acid_sphingomyelinase	33,54	Ezetimibe	acid sphingomyelinase	MESH:C108606	6609	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Ezetimibe inhibits expression of acid_sphingomyelinase in liver and intestine .
22850130	0	Ezetimibe	0,9	cholesteryl_ester_transfer_protein	69,103	Ezetimibe	cholesteryl ester transfer protein	MESH:C108606	1071	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|END_ENTITY	Ezetimibe , an inhibitor of Niemann-Pick C1-like 1 protein , decreases cholesteryl_ester_transfer_protein in type_2_diabetes_mellitus .
25969718	0	Ezetimibe	0,9	insulin	68,75	Ezetimibe	insulin	MESH:C108606	3630	Chemical	Gene	improves|nsubj|START_ENTITY improves|dobj|resistance resistance|compound|END_ENTITY	Ezetimibe combined with standard diet and exercise therapy improves insulin resistance and atherosclerotic markers in patients with metabolic_syndrome .
20875380	0	Ezetimibe	0,9	serum_amyloid_A	20,35	Ezetimibe	serum amyloid A	MESH:C108606	6287	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|levels levels|compound|END_ENTITY	Ezetimibe decreases serum_amyloid_A levels in HDL3 in hemodialysis patients .
19621636	0	F01WB-1315_A_and_B	1,19	dihydroorotate_dehydrogenase	25,53	F01WB-1315 A and B	dihydroorotate dehydrogenase	null	1723	Chemical	Gene	START_ENTITY|appos|inhibitors inhibitors|amod|END_ENTITY	-LSB- F01WB-1315_A_and_B , two dihydroorotate_dehydrogenase inhibitors from microbial metabolites -RSB- .
11291309	0	F12511	73,79	ACAT	57,61	F12511	ACAT	MESH:C418062	110446(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Overexpression of SR-BI in hamsters treated with a novel ACAT inhibitor -LRB- F12511 -RRB- .
20876359	0	F1296	15,20	CFTR	34,38	F1296	CFTR	null	373725(Tax:8355)	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of F1296 and N1303 of CFTR in induced-fit conformational change in response to ATP binding at NBD2 .
22147258	0	F13640	97,103	5-HT1A	130,136	F13640	5-HT1A	MESH:C473959	24473(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|receptors receptors|amod|END_ENTITY	In vivo electrophysiological and neurochemical effects of the selective 5-HT1A receptor agonist , F13640 , at pre - and postsynaptic 5-HT1A receptors in the rat .
16921393	0	F13714	121,127	5-HT1A	105,111	F13714	5-HT1A	MESH:C119079	24473(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Rapid desensitization of somatodendritic 5-HT1A receptors by chronic administration of the high-efficacy 5-HT1A agonist , F13714 : a microdialysis study in the rat .
16921393	0	F13714	121,127	5-HT1A	41,47	F13714	5-HT1A	MESH:C119079	24473(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY administration|nmod|agonist receptors|nmod|administration receptors|amod|END_ENTITY	Rapid desensitization of somatodendritic 5-HT1A receptors by chronic administration of the high-efficacy 5-HT1A agonist , F13714 : a microdialysis study in the rat .
23828155	0	F15599	31,37	5-HT1A_receptor	57,72	F15599	5-HT1A receptor	MESH:C524188	15550(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Aggression-reducing effects of F15599 , a novel selective 5-HT1A_receptor agonist , after microinjection into the ventral orbital prefrontal cortex , but not in infralimbic cortex in male mice .
10640319	0	FA-70	0,5	monoamine_oxidase-A	42,61	FA-70	monoamine oxidase-A	MESH:C404150	17161(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	FA-70 , a novel selective and irreversible monoamine_oxidase-A inhibitor : effect on monoamine metabolism in mouse cerebral cortex .
14555654	0	FAD	114,117	Flx1p	97,102	FAD	Flx1p	MESH:D005182	854672(Tax:4932)	Chemical	Gene	export|compound|START_ENTITY carrier|nmod|export carrier|amod|END_ENTITY	Riboflavin uptake and FAD synthesis in Saccharomyces_cerevisiae mitochondria : involvement of the Flx1p carrier in FAD export .
18279395	0	FAD	118,121	Flx1p	135,140	FAD	Flx1p	MESH:D005182	854672(Tax:4932)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Succinate dehydrogenase flavoprotein subunit expression in Saccharomyces_cerevisiae -- involvement of the mitochondrial FAD transporter , Flx1p .
2777772	0	FAD	30,33	xanthine_dehydrogenase	92,114	FAD	xanthine dehydrogenase	MESH:D005182	497811(Tax:10116)	Chemical	Gene	Differences|nmod|START_ENTITY Differences|nmod|END_ENTITY	Differences in environment of FAD between NAD-dependent and O2-dependent types of rat liver xanthine_dehydrogenase shown by active site probe study .
20699715	0	FAD286	0,6	aldosterone_synthase	11,31	FAD286	aldosterone synthase	MESH:D017316	13072(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	FAD286 , an aldosterone_synthase inhibitor , reduced atherosclerosis and inflammation in apolipoprotein_E-deficient mice .
11549463	0	FAUC_179	154,162	dopamine_D4_receptor	116,136	FAUC 179	dopamine D4 receptor	MESH:C448503	1815	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Benzamide bioisosteres incorporating dihydroheteroazole substructures : EPC synthesis and SAR leading to a selective dopamine_D4_receptor partial agonist -LRB- FAUC_179 -RRB- .
15007532	0	FAUC_213	0,8	dopamine_D4_receptor	29,49	FAUC 213	dopamine D4 receptor	MESH:C477900	1815	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	FAUC_213 , a highly selective dopamine_D4_receptor full antagonist , exhibits atypical antipsychotic properties in behavioural and neurochemical models of schizophrenia .
11495580	0	FAUC_213	177,185	dopamine_d4_receptor	46,66	FAUC 213	dopamine d4 receptor	MESH:C477900	1815	Chemical	Gene	pyridine|appos|START_ENTITY based|nsubj|pyridine based|dobj|tuning tuning|nmod|END_ENTITY	Rationally based efficacy tuning of selective dopamine_d4_receptor ligands leading to the complete antagonist 2 - -LSB- 4 - -LRB- 4-chlorophenyl -RRB- piperazin-1-ylmethyl -RSB- pyrazolo -LSB- 1,5-a -RSB- pyridine -LRB- FAUC_213 -RRB- .
12963489	0	FAUC_329	141,149	dopamine_D3-receptor	104,124	FAUC 329	dopamine D3-receptor	MESH:C477900	13490(Tax:10090)	Chemical	Gene	agonist|acl|START_ENTITY agonist|amod|END_ENTITY	Attenuation of 1-methyl-4-phenyl-1 ,2,3,6 - tetrahydropyridine -LRB- MPTP -RRB- neurotoxicity by the novel selective dopamine_D3-receptor partial agonist FAUC_329 predominantly in the nucleus accumbens of mice .
22447116	0	FB2	51,54	P-glycoprotein	8,22	FB2	P-glycoprotein	null	287115(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of P-glycoprotein in intestinal absorption of FB2 , a promising Abl/Src dual tyrosine kinase inhibitor .
26620764	0	FC-99	22,27	TLR2	37,41	FC-99	TLR2	MESH:C051585	24088(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dep|signaling signaling|nsubj|END_ENTITY	Benzenediamine analog FC-99 inhibits TLR2 and TLR4 signaling in peritoneal macrophage in vitro .
24903157	0	FC-99	38,43	TLR3	55,59	FC-99	TLR3	MESH:C051585	142980(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	A novel 1,2-benzenediamine derivative FC-99 suppresses TLR3 expression and ameliorates disease symptoms in a mouse model of sepsis .
12743452	0	FC12	25,29	IL-1beta	33,41	FC12	IL-1beta	MESH:C007782	3553	Chemical	Gene	a|compound|START_ENTITY a|appos|END_ENTITY	Genetic variants of TNF - -LSB- FC12 -RSB- a , IL-1beta , IL-4 receptor -LSB- FC12 -RSB- a-chain , IL-6 and IL-10 genes are not risk factors for sepsis in low-birth-weight infants .
2516584	0	FCE_24304	60,69	Aromatase	0,9	FCE 24304	Aromatase	MESH:C056516	25147(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY END_ENTITY|dobj|activity	Aromatase inhibition and experimental antitumor activity of FCE_24304 , MDL_18962 and SH_489 .
1173769	0	FD-008	26,32	dopamine_beta-hydroxylase	40,65	FD-008	dopamine beta-hydroxylase	MESH:C009958	25699(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Pharmacological action of FD-008 , a new dopamine_beta-hydroxylase inhibitor .
15061261	0	FDG	45,48	P-glycoprotein	0,14	FDG	P-glycoprotein	null	5243	Chemical	Gene	uptake|compound|START_ENTITY associated|nmod|uptake associated|nsubjpass|expression expression|amod|END_ENTITY	P-glycoprotein expression is associated with FDG uptake and cell differentiation in patients with untreated lung_cancer .
19408578	0	FDG	21,24	glucose_transporter_type_1	51,77	FDG	glucose transporter type 1	null	6513	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|END_ENTITY	Relationship between FDG uptake and expressions of glucose_transporter_type_1 , type 3 , and hexokinase-II in Reed-Sternberg cells of Hodgkin_lymphoma .
12006367	0	FFA	19,22	IGF-I	10,15	FFA	IGF-I	CHEBI:42638	3479	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of IGF-I on FFA and glucose metabolism in control and type 2 diabetic subjects .
7715845	0	FG_7142	44,51	cholecystokinin	60,75	FG 7142	cholecystokinin	MESH:C035874	25298(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	The benzodiazepine receptor inverse agonist FG_7142 induces cholecystokinin gene expression in rat brain .
22392998	0	FICZ	77,81	aryl_hydrocarbon_receptor	119,144	FICZ	aryl hydrocarbon receptor	null	196	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Inhibition of cytochrome P4501-dependent clearance of the endogenous agonist FICZ as a mechanism for activation of the aryl_hydrocarbon_receptor .
23700428	0	FK-16	0,5	LL-37	42,47	FK-16	LL-37	null	820	Chemical	Gene	START_ENTITY|acl|derived derived|nmod|END_ENTITY	FK-16 derived from the anticancer peptide LL-37 induces caspase-independent apoptosis and autophagic cell death in colon_cancer cells .
1384862	0	FK-506	15,21	IL-2	102,106	FK-506	IL-2	MESH:D016559	3558	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|response response|nmod|END_ENTITY	The effects of FK-506 and cyclosporin_A on the proliferation of PHA-stimulated T cells in response to IL-2 , IL-4 or IL-6 .
1377361	0	FK-506	0,6	interleukin-2	44,57	FK-506	interleukin-2	MESH:D016559	3558	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	FK-506 - and CsA-sensitive activation of the interleukin-2 promoter by calcineurin .
16125538	0	FK-614	0,6	peroxisome_proliferator-activated_receptor_gamma	20,68	FK-614	peroxisome proliferator-activated receptor gamma	null	403606(Tax:9615)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	FK-614 , a selective peroxisome_proliferator-activated_receptor_gamma agonist , improves peripheral glucose utilization while decreasing hepatic insulin extraction in alloxan-induced diabetic dogs .
18602914	0	FK1706	0,6	neurophilin	38,49	FK1706	neurophilin	MESH:C505380	25501(Tax:10116)	Chemical	Gene	START_ENTITY|appos|ligand ligand|compound|END_ENTITY	FK1706 , a novel non-immunosuppressant neurophilin ligand , ameliorates motor_dysfunction following spinal_cord_injury through its neuroregenerative action .
9117514	0	FK224	41,46	NK1_receptor	15,27	FK224	NK1 receptor	MESH:C075570	100135626(Tax:10141)	Chemical	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	The effects of NK1_receptor antagonists -LRB- FK224 and FK888 -RRB- on agonist - and antigen-induced nasal microvascular leakage in guinea_pigs .
9243258	0	FK224	22,27	substance_P	52,63	FK224	substance P	MESH:C075570	6863	Chemical	Gene	neurokinin_A|compound|START_ENTITY neurokinin_A|dep|END_ENTITY	Tachykinin antagonist FK224 inhibits neurokinin_A - , substance_P - and capsaicin-induced human bronchial contraction .
16278420	0	FK228	30,35	Prdx1	63,68	FK228	Prdx1	MESH:C087123	5052	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Histone deacetylase inhibitor FK228 activates tumor suppressor Prdx1 with apoptosis induction in esophageal_cancer cells .
11192923	0	FK3311	41,47	cyclooxygenase-2	14,30	FK3311	cyclooxygenase-2	MESH:C085566	442942(Tax:9615)	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|inhibitor inhibitor|amod|END_ENTITY	The effect of cyclooxygenase-2 inhibitor FK3311 on ischemia-reperfusion injury in a canine total hepatic vascular exclusion model .
17523312	0	FK3311	45,51	cyclooxygenase-2	17,33	FK3311	cyclooxygenase-2	MESH:C085566	29527(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	The effects of a cyclooxygenase-2 inhibitor , FK3311 , on total hepatic_ischemia-reperfusion injury of the rat .
12706475	0	FK3657	10,16	bradykinin_B2_receptor	32,54	FK3657	bradykinin B2 receptor	null	100135486(Tax:10141)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|antagonist antagonist|amod|END_ENTITY	Effect of FK3657 , a non-peptide bradykinin_B2_receptor antagonist , on allergic airway_disease models .
9667521	0	FK480	41,46	CCK-A_receptor	50,64	FK480	CCK-A receptor	MESH:C082966	24889(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Augmentation of the inhibitory effect of FK480 , a CCK-A_receptor antagonist , on pancreatic exocrine secretion by achlorhydria .
9788545	0	FK480	10,15	CCK-A_receptor	19,33	FK480	CCK-A receptor	MESH:C082966	24889(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Effect of FK480 , a CCK-A_receptor antagonist , on spontaneously developed chronic_pancreatitis in WBN/Kob rats .
23867624	0	FK506	0,5	BMPR2	16,21	FK506	BMPR2	MESH:D016559	140590(Tax:10116)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	FK506 activates BMPR2 , rescues endothelial_dysfunction , and reverses pulmonary_hypertension .
21941688	0	FK506	11,16	CA1	32,35	FK506	CA1	MESH:D016559	310218(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|Cells Cells|compound|END_ENTITY	Effects of FK506 on Hippocampal CA1 Cells Following Transient Global_Ischemia / Reperfusion in Wistar Rat .
15598440	0	FK506	0,5	E-selectin	17,27	FK506	E-selectin	MESH:D016559	6401	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	FK506 suppresses E-selectin , ICAM-1 and VCAM-1 expression on vascular endothelial cells by inhibiting tumor_necrosis_factor_alpha secretion from peripheral blood mononuclear cells .
7533090	0	FK506	54,59	FK506_binding_protein_12	0,24	FK506	FK506 binding protein 12	MESH:D016559	14225(Tax:10090)	Chemical	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	FK506_binding_protein_12 mediates sensitivity to both FK506 and rapamycin in murine mast cells .
1375171	0	FK506	22,27	FKBP-12	37,44	FK506	FKBP-12	MESH:D016559	2285	Chemical	Gene	structure|nmod|START_ENTITY bound|nsubj|structure bound|nmod|END_ENTITY	Solution structure of FK506 bound to FKBP-12 .
11557049	2	FK506	479,484	FKBP12	363,369	FK506	FKBP12	MESH:D016559	2285	Chemical	Gene	displaced|nmod|START_ENTITY microsomes|acl:relcl|displaced demonstrated|nmod|microsomes demonstrated|nsubj|END_ENTITY	FKBP12 demonstrated a very tight , high affinity association with skeletal muscle microsomes , which was displaced by FK506 .
12085010	0	FK506	19,24	FKBP12	0,6	FK506	FKBP12	MESH:D016559	14225(Tax:10090)	Chemical	Gene	protein|compound|START_ENTITY protein|nsubj|END_ENTITY	FKBP12 is the only FK506 binding protein mediating T-cell inhibition by the immunosuppressant FK506 .
12085010	0	FK506	94,99	FKBP12	0,6	FK506	FKBP12	MESH:D016559	14225(Tax:10090)	Chemical	Gene	mediating|nmod|START_ENTITY protein|acl|mediating protein|nsubj|END_ENTITY	FKBP12 is the only FK506 binding protein mediating T-cell inhibition by the immunosuppressant FK506 .
15299839	0	FK506	125,130	FKBP12	65,71	FK506	FKBP12	MESH:D016559	2285	Chemical	Gene	protein|nmod|START_ENTITY Design|appos|protein Design|nmod|inhibitors inhibitors|nmod|END_ENTITY	Design , synthesis and structure of non-macrocyclic inhibitors of FKBP12 , the major binding protein for the immunosuppressant FK506 .
19361439	0	FK506	129,134	FKBP12	81,87	FK506	FKBP12	MESH:D016559	2285	Chemical	Gene	binding|dobj|START_ENTITY END_ENTITY|acl|binding	Differential responses of the backbone and side-chain conformational dynamics in FKBP12 upon binding the transition-state analog FK506 : implications for transition-state stabilization and target protein recognition .
8545894	0	FK506	68,73	FKBP12	28,34	FK506	FKBP12	MESH:D016559	2285	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Inhibitory effect of plasma FKBP12 on immunosuppressive activity of FK506 .
8563622	0	FK506	109,114	FKBP12	60,66	FK506	FKBP12	MESH:D016559	2285	Chemical	Gene	complexes|nmod|START_ENTITY complexes|compound|END_ENTITY	Structure comparison of native and mutant human recombinant FKBP12 complexes with the immunosuppressant drug FK506 -LRB- tacrolimus -RRB- .
9223178	0	FK506	45,50	FKBP12	23,29	FK506	FKBP12	MESH:D016559	2285	Chemical	Gene	complexes|nmod|START_ENTITY complexes|nummod|END_ENTITY	Mean field analysis of FKBP12 complexes with FK506 and rapamycin : implications for a role of crystallographic water molecules in molecular recognition and specificity .
26749369	0	FK506	85,90	FKBP25	62,68	FK506	FKBP25	MESH:D016559	2287	Chemical	Gene	complex|nmod|START_ENTITY END_ENTITY|nmod|complex	Crystal structure of the FK506 binding domain -LRB- FKBD -RRB- of human FKBP25 in complex with FK506 .
12169765	0	FK506	10,15	GAP-43	62,68	FK506	GAP-43	MESH:D016559	29423(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of FK506 on neurotransmitter content and expression of GAP-43 in neurotoxin-lesioned peripheral sensory and sympathetic neurons .
9502207	0	FK506	22,27	GAP-43	38,44	FK506	GAP-43	MESH:D016559	29423(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|compound|END_ENTITY	The immunosuppressant FK506 increases GAP-43 mRNA levels in axotomized sensory neurons .
9878202	0	FK506	12,17	GAP-43	52,58	FK506	GAP-43	MESH:D016559	29423(Tax:10116)	Chemical	Gene	Tacrolimus|appos|START_ENTITY increases|nsubj|Tacrolimus increases|dobj|expression expression|nmod|END_ENTITY	Tacrolimus -LRB- FK506 -RRB- increases neuronal expression of GAP-43 and improves functional recovery after spinal_cord_injury in rats .
17067582	0	FK506	21,26	HIF1alpha	43,52	FK506	HIF1alpha	MESH:D016559	3091	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|expression expression|amod|END_ENTITY	Immunophilin-ligands FK506 and CsA inhibit HIF1alpha expression by a VHL - and ubiquitin-independent mechanism .
11357886	0	FK506	11,16	IL-6	97,101	FK506	IL-6	MESH:D016559	3569	Chemical	Gene	Effects|nmod|START_ENTITY mediated|nsubj|Effects mediated|dobj|production production|amod|END_ENTITY	Effects of FK506 and other immunosuppressive anti-rheumatic agents on T cell activation mediated IL-6 and IgM production in vitro .
18475583	0	FK506	0,5	IL-6	32,36	FK506	IL-6	MESH:D016559	3569	Chemical	Gene	Production|compound|START_ENTITY Production|compound|END_ENTITY	FK506 and Cyclosporin_A Enhance IL-6 Production in Monocytes : A single-Cell Assay .
10329481	0	FK506	27,32	IL-8	42,46	FK506	IL-8	MESH:D016559	3576	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	A potent immunosuppressant FK506 inhibits IL-8 expression in human eosinophils .
25580011	0	FK506	89,94	Imp2	0,4	FK506	Imp2	MESH:D016559	319765(Tax:10090)	Chemical	Gene	affects|nmod|START_ENTITY affects|nsubj|END_ENTITY	Imp2 , the PSTPIP homolog in fission_yeast , affects sensitivity to the immunosuppressant FK506 and membrane trafficking in fission_yeast .
10928971	0	FK506	0,5	TNF-alpha	50,59	FK506	TNF-alpha	MESH:D016559	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	FK506 potently inhibits T cell activation induced TNF-alpha and IL-1beta production in vitro by human peripheral blood mononuclear cells .
26823720	0	FK506	0,5	TRPC6	84,89	FK506	TRPC6	MESH:D016559	89823(Tax:10116)	Chemical	Gene	ameliorates|nsubj|START_ENTITY ameliorates|nmod|END_ENTITY	FK506 ameliorates podocyte injury in type 2 diabetic_nephropathy by down-regulating TRPC6 and NFAT expression .
11408029	0	FK506	0,5	alpha1-acid_glycoprotein	33,57	FK506	alpha1-acid glycoprotein	MESH:D016559	24614(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	FK506 -LRB- tacrolimus -RRB- increases rat alpha1-acid_glycoprotein expression in liver and primary cultured hepatocytes .
12427484	0	FK506	10,15	bone_morphogenetic_protein-2	55,83	FK506	bone morphogenetic protein-2	MESH:D016559	650	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of FK506 on osteoinduction by recombinant human bone_morphogenetic_protein-2 .
1283385	0	FK506	45,50	cyclosporin_A	96,109	FK506	cyclosporin A	MESH:D016559	1161	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of the new immunosuppressive drug FK506 on the formation of secondary metabolites of cyclosporin_A .
21310938	0	FK506	17,22	endoglin	33,41	FK506	endoglin	MESH:D016559	2022	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Immunosuppressor FK506 increases endoglin and activin receptor-like kinase 1 expression and modulates transforming_growth_factor-b1 signaling in endothelial cells .
8603582	0	FK506	24,29	growth_hormone	41,55	FK506	growth hormone	MESH:D016559	81668(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|amod|END_ENTITY	Immunosuppressant agent FK506 stimulates growth_hormone -LRB- GH -RRB- secretion and gene expression of hypothalamic GH-releasing hormone in the rat .
18480987	0	FK506	10,15	hepatocyte_growth_factor	33,57	FK506	hepatocyte growth factor	MESH:D016559	15234(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of FK506 on expression of hepatocyte_growth_factor in murine spinal cord following peripheral_nerve_injury .
19500470	0	FK506	21,26	insulin	87,94	FK506	insulin	MESH:D016559	3630	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	Different effects of FK506 , rapamycin , and mycophenolate_mofetil on glucose-stimulated insulin release and apoptosis in human islets .
7678356	0	FK506	103,108	insulin	33,40	FK506	insulin	MESH:D016559	3630	Chemical	Gene	analog|nmod|START_ENTITY release|nmod|analog release|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of glucose-stimulated insulin release from beta_TC3 cells and rodent islets by an analog of FK506 .
8965835	0	FK506	111,116	interferon-gamma	10,26	FK506	interferon-gamma	MESH:D016559	15978(Tax:10090)	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|expression expression|amod|END_ENTITY	Increased interferon-gamma mRNA expression following alloincompatible myoblast transplantation is inhibited by FK506 .
15860218	0	FK506	0,5	interleukin-1beta	77,94	FK506	interleukin-1beta	MESH:D016559	16176(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	FK506 suppresses the stimulation of matrix_metalloproteinase_13 synthesis by interleukin-1beta in rheumatoid synovial fibroblasts .
7528280	0	FK506	0,5	interleukin_6	48,61	FK506	interleukin 6	MESH:D016559	3569	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	FK506 , an immunosuppressant , partially inhibits interleukin_6 production by adherent rheumatoid synovial cells .
16303143	0	FK506	18,23	matrix_metalloproteinase-9	33,59	FK506	matrix metalloproteinase-9	MESH:D016559	4318	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|induction induction|amod|END_ENTITY	Immunosuppressant FK506 inhibits matrix_metalloproteinase-9 induction in TNF-alpha-stimulated human hepatic stellate cells .
15377358	0	FK506	0,5	nitric_oxide_synthase	92,113	FK506	nitric oxide synthase	MESH:D016559	4843	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	FK506 independently upregulates transforming_growth_factor_beta and downregulates inducible nitric_oxide_synthase in cultured human keratinocytes : possible mechanisms of how tacrolimus ointment interacts with atopic skin .
23800841	0	FK506	0,5	prion_protein	23,36	FK506	prion protein	MESH:D016559	19122(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	FK506 reduces abnormal prion_protein through the activation of autolysosomal degradation and prolongs survival in prion-infected mice .
1284044	0	FK506	30,35	progesterone_receptor	69,90	FK506	progesterone receptor	MESH:D016559	100009094(Tax:9986)	Chemical	Gene	START_ENTITY|nmod|function function|nmod|END_ENTITY	-LSB- Effect of immunosuppressants FK506 and rapamycin on the function of progesterone_receptor : protein `` p59-HBI '' , intersection between immunology and endocrinology ? -RSB- .
7476967	0	FK506	67,72	progesterone_receptor	19,40	FK506	progesterone receptor	MESH:D016559	5241	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of the progesterone_receptor with binding proteins for FK506 and cyclosporin_A .
7510997	0	FK506	30,35	progesterone_receptor	86,107	FK506	progesterone receptor	MESH:D016559	5241	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|form form|nmod|END_ENTITY	Effects of immunosuppressants FK506 and rapamycin on the heterooligomeric form of the progesterone_receptor .
8251509	0	FK506	39,44	rotamase	18,26	FK506	rotamase	MESH:D016559	60681	Chemical	Gene	protein|compound|START_ENTITY activity|nmod|protein activity|amod|END_ENTITY	Mechanism for the rotamase activity of FK506 binding protein from molecular dynamics simulations .
21995851	0	FK506	0,5	thioredoxin	66,77	FK506	thioredoxin	MESH:D016559	116484(Tax:10116)	Chemical	Gene	neuroprotection|nummod|START_ENTITY mediated|nsubjpass|neuroprotection mediated|nmod|systems systems|compound|END_ENTITY	FK506 neuroprotection after cavernous nerve_injury is mediated by thioredoxin and glutathione redox systems .
21995851	0	FK506	0,5	thioredoxin	66,77	FK506	thioredoxin	MESH:D016559	116484(Tax:10116)	Chemical	Gene	neuroprotection|nummod|START_ENTITY mediated|nsubjpass|neuroprotection mediated|nmod|systems systems|compound|END_ENTITY	FK506 neuroprotection after cavernous nerve_injury is mediated by thioredoxin and glutathione redox systems .
7577807	0	FK506	83,88	thioredoxin	58,69	FK506	thioredoxin	MESH:D016559	7295	Chemical	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	Suppression of adult_T_cell_leukemia-derived_factor / human thioredoxin induction by FK506 and cyclosporin_A : a new mechanism of immune modulation via redox control .
7515742	0	FK565	79,84	interleukin-6	17,30	FK565	interleukin-6	MESH:C039537	16193(Tax:10090)	Chemical	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	The induction of interleukin-6 -LRB- IL-6 -RRB- and colony-stimulating factors -LRB- CSFs -RRB- by FK565 and its thrombopoietic activity following in vivo administration .
16314690	0	FK614	0,5	peroxisome_proliferator-activated_receptor_gamma	15,63	FK614	peroxisome proliferator-activated receptor gamma	null	5468	Chemical	Gene	START_ENTITY|appos|modulator modulator|amod|END_ENTITY	FK614 , a novel peroxisome_proliferator-activated_receptor_gamma modulator , induces differential transactivation through a unique ligand-specific interaction with transcriptional coactivators .
17391165	0	FK614	107,112	peroxisome_proliferator-activated_receptor_gamma	49,97	FK614	peroxisome proliferator-activated receptor gamma	null	25664(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	Mechanism by which a novel non-thiazolidinedione peroxisome_proliferator-activated_receptor_gamma agonist , FK614 , ameliorates insulin resistance in Zucker fatty rats .
9733156	0	FK633	35,40	fibrinogen	57,67	FK633	fibrinogen	MESH:C103087	2244	Chemical	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	Characterization of the binding of FK633 to the platelet fibrinogen receptor .
15919520	0	FK778	22,27	NF-kappaB	51,60	FK778	NF-kappaB	MESH:C115284	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	The malononitrilamide FK778 inhibits activation of NF-kappaB in human dendritic cells .
22728882	0	FK866	31,36	NAMPT	14,19	FK866	NAMPT	MESH:C480543	10135	Chemical	Gene	pathway|nmod|START_ENTITY pathway|amod|END_ENTITY	Inhibition of NAMPT pathway by FK866 activates the function of p53 in HEK293T cells .
21743967	0	FK866	95,100	Nampt	18,23	FK866	Nampt	MESH:C480543	10135	Chemical	Gene	Overexpression|nmod|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of Nampt in gastric_cancer and chemopotentiating effects of the Nampt inhibitor FK866 in combination with fluorouracil .
14612543	0	FK866	0,5	nicotinamide_phosphoribosyltransferase	53,91	FK866	nicotinamide phosphoribosyltransferase	MESH:C480543	10135	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	FK866 , a highly specific noncompetitive inhibitor of nicotinamide_phosphoribosyltransferase , represents a novel mechanism for induction of tumor cell apoptosis .
24169192	0	FK866	0,5	visfatin	9,17	FK866	visfatin	MESH:C480543	59027(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	FK866 , a visfatin inhibitor , protects against acute_lung_injury after intestinal_ischemia-reperfusion in mice via NF-kB pathway .
15863919	0	FK888	92,97	NK1	99,102	FK888	NK1	MESH:C078949	6869	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Effect of structural relaxation on the physical and aerosol properties of amorphous form of FK888 -LRB- NK1 antagonist -RRB- .
7692529	0	FK888	34,39	NK1	59,62	FK888	NK1	MESH:C078949	6869	Chemical	Gene	properties|nmod|START_ENTITY dipeptide|nsubj|properties dipeptide|dobj|antagonist antagonist|compound|END_ENTITY	The pharmacological properties of FK888 , a novel dipeptide NK1 antagonist .
1282073	0	FK888	78,83	NK1_receptor	53,65	FK888	NK1 receptor	MESH:C078949	100135626(Tax:10141)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Pharmacological profile of a high affinity dipeptide NK1_receptor antagonist , FK888 .
7686493	0	FK888	39,44	NK1_receptor	14,26	FK888	NK1 receptor	MESH:C078949	100135626(Tax:10141)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Effects of an NK1_receptor antagonist , FK888 , on constriction and plasma extravasation induced in guinea_pig airway by neurokinins and capsaicin .
8255547	0	FK888	23,28	NK1_receptor	48,60	FK888	NK1 receptor	MESH:C078949	24807(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY dipeptide|nsubj|Effects dipeptide|dobj|antagonist antagonist|amod|END_ENTITY	Effects of intrathecal FK888 , a novel dipeptide NK1_receptor antagonist , on the formalin test in the rat .
8364945	0	FK906	29,34	renin	50,55	FK906	renin	MESH:C083010	5972	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Antihypertensive efficacy of FK906 , a novel human renin inhibitor .
9608396	0	FK906	42,47	renin	26,31	FK906	renin	MESH:C083010	5972	Chemical	Gene	START_ENTITY|nsubj|Microencapsulation Microencapsulation|nmod|inhibitor inhibitor|compound|END_ENTITY	Microencapsulation of the renin inhibitor FK906 by phase separation of ethylcellulose in cyclohexane .
7862614	0	FK_33-824	48,57	growth_hormone	7,21	FK 33-824	growth hormone	MESH:D005405	378781(Tax:9031)	Chemical	Gene	response|nmod|START_ENTITY END_ENTITY|dobj|response	Plasma growth_hormone and prolactin response to FK_33-824 , a synthetic opioid agonist , in broiler chickens .
3770354	0	FK_33-824	40,49	motilin	61,68	FK 33-824	motilin	MESH:D005405	4295	Chemical	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of methionine-enkephalin analog -LRB- FK_33-824 -RRB- on plasma motilin .
8061811	0	FK_480	44,50	cholecystokinin	16,31	FK 480	cholecystokinin	MESH:C082966	25298(Tax:10116)	Chemical	Gene	Effect|appos|START_ENTITY Effect|nmod|antagonist antagonist|compound|END_ENTITY	Effect of a new cholecystokinin antagonist -LRB- FK_480 -RRB- on gene expression of cholecystokinin and secretin in rat intestine .
7517020	0	FK_506	0,6	vascular_permeability_factor	11,39	FK 506	vascular permeability factor	MESH:D016559	7422	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	FK_506 for vascular_permeability_factor production in minimal change_nephrotic_syndrome .
24565895	0	FL442	28,33	androgen_receptor	56,73	FL442	androgen receptor	null	367	Chemical	Gene	START_ENTITY|appos|modulator modulator|compound|END_ENTITY	Preclinical pharmacology of FL442 , a novel nonsteroidal androgen_receptor modulator .
7136724	0	FLA-57	48,54	dopamine-beta-hydroxylase	11,36	FLA-57	dopamine-beta-hydroxylase	MESH:C015590	25699(Tax:10116)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Effects of dopamine-beta-hydroxylase inhibitors FLA-57 and FLA-63 on ethanol metabolism and aldehyde_dehydrogenase activity in rats .
7826903	0	FLAC	26,30	GM-CSF	183,189	FLAC	GM-CSF	null	1437	Chemical	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	A dose intensity study of FLAC -LRB- 5-fluorouracil , leucovorin , doxorubicin , cyclophosphamide -RRB- chemotherapy and Escherichia_coli-derived granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- in advanced breast_cancer patients .
20818158	0	FLLL32	50,56	STAT3	79,84	FLLL32	STAT3	MESH:C548902	6774	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	IL-6 , a risk factor for hepatocellular_carcinoma : FLLL32 inhibits IL-6-induced STAT3 phosphorylation in human hepatocellular_cancer cells .
16619525	0	FLT3-ITD	80,88	FLT3	0,4	FLT3-ITD	FLT3	null	2322	Chemical	Gene	overexpression|nmod|START_ENTITY overexpression|nsubj|END_ENTITY	FLT3 overexpression in acute_promyelocytic_leukemia patients without detectable FLT3-ITD or codon 835-836 mutations : a pilot study .
21537333	0	FLT3-ITD	21,29	NPM1	38,42	FLT3-ITD	NPM1	null	4869	Chemical	Gene	load|compound|START_ENTITY load|nmod|END_ENTITY	Prognostic impact of FLT3-ITD load in NPM1 mutated acute myeloid_leukemia .
22517899	0	FLT3-ITD	22,30	SOCS1	0,5	FLT3-ITD	SOCS1	null	12703(Tax:10090)	Chemical	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	SOCS1 cooperates with FLT3-ITD in the development of myeloproliferative_disease by promoting the escape from external cytokine control .
21527514	0	FLT3-ITD	25,33	p90RSK2	0,7	FLT3-ITD	p90RSK2	null	6197	Chemical	Gene	essential|nmod|START_ENTITY essential|nsubj|END_ENTITY	p90RSK2 is essential for FLT3-ITD - but dispensable for BCR-ABL-induced myeloid_leukemia .
23943874	0	FLT3_ITD	72,80	K-Ras	97,102	FLT3 ITD	K-Ras	null	3845	Chemical	Gene	signals|nsubj|START_ENTITY signals|nmod|END_ENTITY	Features of Ras activation by a mislocalized oncogenic tyrosine kinase : FLT3_ITD signals through K-Ras at the plasma membrane of acute_myeloid_leukemia cells .
26464656	0	FLZ	24,27	ICAM-1	51,57	FLZ	ICAM-1	null	3383	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Squamosamide derivative FLZ inhibits TNF-a-induced ICAM-1 expression via down-regulation of the NF-kB signaling pathway in ARPE-19 cells .
6618342	0	FM-100	47,53	gastrin	78,85	FM-100	gastrin	MESH:C035049	25320(Tax:10116)	Chemical	Gene	administration|amod|START_ENTITY administration|nmod|levels levels|compound|END_ENTITY	-LSB- Effects of single and combined administration FM-100 and cimetidine on serum gastrin levels in rats -RSB- .
7087261	0	FM100	11,16	gastrin	56,63	FM100	gastrin	MESH:C035049	25320(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|concentration concentration|compound|END_ENTITY	Effects of FM100 , a fraction of licorice root , on serum gastrin concentration in rats and dogs .
8988517	0	FMRFamide	33,42	LPa2	84,88	FMRFamide	LPa2	MESH:D019835	9170	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Direct and modulatory effects of FMRFamide , SKPYMRFamide and acety1-SKPYMRFamide on LPa2 , LPa3 , and RPa3 identified neurons of Helix lucorum .
17334410	0	FR-167653	0,9	p38	23,26	FR-167653	p38	MESH:C104334	81649(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	FR-167653 , a selective p38 MAPK inhibitor , exerts salutary effect on liver cirrhosis through downregulation of Runx2 .
12060566	0	FR-167653	22,31	p38_MAPK	2,10	FR-167653	p38 MAPK	MESH:C104334	26416(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	A p38_MAPK inhibitor , FR-167653 , ameliorates murine bleomycin-induced pulmonary_fibrosis .
1382375	0	FR110302	28,36	5-lipoxygenase	2,16	FR110302	5-lipoxygenase	MESH:C074243	25290(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	A 5-lipoxygenase inhibitor , FR110302 , suppresses airway_hyperresponsiveness_and_lung_eosinophilia induced by Sephadex particles in rats .
9810693	2	FR110302	106,114	5-lipoxygenase	147,161	FR110302	5-lipoxygenase	MESH:C074243	25290(Tax:10116)	Chemical	Gene	resolution|nmod|START_ENTITY Discovery|appos|resolution Discovery|appos|inhibitor inhibitor|amod|END_ENTITY	Discovery , optical resolution and enantioselective synthesis of FR110302 , a highly potent non-redox type 5-lipoxygenase inhibitor .
7901036	0	FR121196	82,90	somatostatin	8,20	FR121196	somatostatin	MESH:C077882	100730851	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of somatostatin in the augmentation of hippocampal long-term potentiation by FR121196 , a putative cognitive_enhancer .
11834626	0	FR122047	23,31	cyclo-oxygenase-1	45,62	FR122047	cyclo-oxygenase-1	MESH:C085131	24693(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Differential effect of FR122047 , a selective cyclo-oxygenase-1 inhibitor , in rat chronic models of arthritis .
10720634	0	FR122047	32,40	cyclooxygenase-1	54,70	FR122047	cyclooxygenase-1	MESH:C085131	19224(Tax:10090)	Chemical	Gene	profile|nmod|START_ENTITY profile|appos|inhibitor inhibitor|amod|END_ENTITY	The analgesic effect profile of FR122047 , a selective cyclooxygenase-1 inhibitor , in chemical nociceptive models .
15627832	0	FR122047	41,49	cyclooxygenase_1	63,79	FR122047	cyclooxygenase 1	MESH:C085131	100009407(Tax:9986)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effects of intravenous administration of FR122047 -LRB- a selective cyclooxygenase_1 inhibitor -RRB- and FR188582 -LRB- a selective cyclooxygenase_2 inhibitor -RRB- on prostaglandin-E2-induced aqueous flare elevation in pigmented rabbits .
15627832	0	FR122047	41,49	cyclooxygenase_2	117,133	FR122047	cyclooxygenase 2	MESH:C085131	100009248(Tax:9986)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effects of intravenous administration of FR122047 -LRB- a selective cyclooxygenase_1 inhibitor -RRB- and FR188582 -LRB- a selective cyclooxygenase_2 inhibitor -RRB- on prostaglandin-E2-induced aqueous flare elevation in pigmented rabbits .
8088357	0	FR128998	10,18	PAF_receptor	28,40	FR128998	PAF receptor	MESH:C089484	58949(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|antagonist antagonist|compound|END_ENTITY	Effect of FR128998 , a novel PAF_receptor antagonist , on endotoxin-induced disseminated_intravascular_coagulation .
1366258	0	FR139317	102,110	ETA	77,80	FR139317	ETA	MESH:C079574	24326(Tax:10116)	Chemical	Gene	START_ENTITY|compound|endothelin endothelin|appos|END_ENTITY	Inhibition of endothelin -LRB- ET-1 -RRB- induced pressor responses by the endothelin -LRB- ETA -RRB- receptor antagonist FR139317 in the pithed rat .
7791103	0	FR139317	96,104	ETA	80,83	FR139317	ETA	MESH:C079574	24326(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	Regulation of ion transport by endothelins in rat colonic mucosa : effects of an ETA antagonist -LRB- FR139317 -RRB- and an ETB agonist -LRB- IRL1620 -RRB- .
7862251	0	FR139317	0,8	endothelin-1	95,107	FR139317	endothelin-1	MESH:C079574	24323(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	FR139317 , a specific ETA-receptor antagonist , inhibits cerebral activation by intraventricular endothelin-1 in conscious rats .
8075866	0	FR139317	39,47	endothelin-1	87,99	FR139317	endothelin-1	MESH:C079574	24323(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY Effects|nmod|antagonist Effects|nmod|responses responses|nmod|Ac-endothelin-1 Ac-endothelin-1|amod|END_ENTITY	Effects of an ET1-receptor antagonist , FR139317 , on regional haemodynamic responses to endothelin-1 and -LSB- Ala11 ,15 -RSB- Ac-endothelin-1 -LRB- 6-21 -RRB- in conscious rats .
11749771	0	FR139317	44,52	endothelin_receptor_A	11,32	FR139317	endothelin receptor A	MESH:C079574	24326(Tax:10116)	Chemical	Gene	antagonist|dobj|START_ENTITY antagonist|nsubj|Effects Effects|nmod|END_ENTITY	Effects of endothelin_receptor_A antagonist FR139317 on rats with congestive_heart_failure .
10864144	0	FR140423	28,36	cyclo-oxygenase-2	56,73	FR140423	cyclo-oxygenase-2	MESH:C108904	29527(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Anti-inflammatory effect of FR140423 , a novel selective cyclo-oxygenase-2 inhibitor , in rat adjuvant arthritis without gastrointestinal_side_effects .
11785783	0	FR140423	76,84	cyclooxygenase-2	48,64	FR140423	cyclooxygenase-2	MESH:C108904	29527(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Anti-inflammatory activity of a novel selective cyclooxygenase-2 inhibitor , FR140423 , on type II collagen-induced arthritis in Lewis rats .
8541332	0	FR145237	10,18	ACAT	28,32	FR145237	ACAT	MESH:C097564	100009537(Tax:9986)	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of FR145237 , a novel ACAT inhibitor , on atherogenesis in cholesterol-fed and WHHL rabbits .
9203620	0	FR167344	67,75	bradykinin	35,45	FR167344	bradykinin	MESH:C106745	3827	Chemical	Gene	antagonists|nummod|START_ENTITY antagonists|compound|END_ENTITY	Novel subtype-selective nonpeptide bradykinin receptor antagonists FR167344 and FR173657 .
9311664	0	FR167344	106,114	bradykinin	71,81	FR167344	bradykinin	MESH:C106745	3827	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Pharmacological characterization of a novel , orally active , nonpeptide bradykinin B2 receptor antagonist , FR167344 .
10100888	0	FR167344	59,67	bradykinin_B2_receptor	24,46	FR167344	bradykinin B2 receptor	MESH:C106745	100135486(Tax:10141)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Effects of a nonpeptide bradykinin_B2_receptor antagonist , FR167344 , on guinea-pig tracheal smooth muscle bradykinin receptors .
21886782	0	FR167653	48,56	P38	0,3	FR167653	P38	MESH:C104334	26416(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|nummod|END_ENTITY	P38 mitogen-activated protein kinase inhibitor , FR167653 , inhibits parathyroid_hormone_related_protein-induced osteoclastogenesis and bone resorption .
16307221	0	FR167653	25,33	TNF-alpha	55,64	FR167653	TNF-alpha	MESH:C104334	21926(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|inhibitor inhibitor|nmod|END_ENTITY	Effect and mechanisms of FR167653 , a dual inhibitor of TNF-alpha and IL-1 , on BCG plus LPS induced-liver_injury .
14744598	0	FR167653	23,31	calreticulin	82,94	FR167653	calreticulin	MESH:C104334	811	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|compound|END_ENTITY	Suppressive effects of FR167653 , an inhibitor of p38 mitogen-activated kinase , on calreticulin mRNA expression induced by endoplasmic_reticulum_stresses .
15454115	0	FR167653	26,34	interleukin-1_and_tumor_necrosis_factor	56,95	FR167653	interleukin-1 and tumor necrosis factor	MESH:C104334	103694380	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|inhibitor inhibitor|nmod|END_ENTITY	Effects and mechanisms of FR167653 , a dual inhibitor of interleukin-1_and_tumor_necrosis_factor , on adjuvant_arthritis in rats .
24383773	0	FR167653	11,19	interleukin-1_and_tumor_necrosis_factor	41,80	FR167653	interleukin-1 and tumor necrosis factor	MESH:C104334	103694380	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|inhibitor inhibitor|nmod|END_ENTITY	Effects of FR167653 , a dual inhibitor of interleukin-1_and_tumor_necrosis_factor , on adjuvant_arthritis in rats .
9200556	0	FR167653	0,8	interleukin-1_and_tumor_necrosis_factor-alpha	30,75	FR167653	interleukin-1 and tumor necrosis factor-alpha	MESH:C104334	100009088(Tax:9986)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	FR167653 , a dual inhibitor of interleukin-1_and_tumor_necrosis_factor-alpha , ameliorates endotoxin-induced shock .
12242095	0	FR167653	29,37	p38	41,44	FR167653	p38	MESH:C104334	26416(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Anti-inflammatory potency of FR167653 , a p38 mitogen-activated protein kinase inhibitor , in mouse models of acute inflammation .
14741738	0	FR167653	68,76	p38	13,16	FR167653	p38	MESH:C104334	26416(Tax:10090)	Chemical	Gene	keeps|nsubj|START_ENTITY inhibitor|ccomp|keeps inhibitor|nsubj|kinase kinase|amod|END_ENTITY	The specific p38 mitogen-activated protein kinase pathway inhibitor FR167653 keeps insulitis benign in nonobese_diabetic mice .
14744598	0	FR167653	23,31	p38	49,52	FR167653	p38	MESH:C104334	1432	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|inhibitor inhibitor|nmod|kinase kinase|amod|END_ENTITY	Suppressive effects of FR167653 , an inhibitor of p38 mitogen-activated kinase , on calreticulin mRNA expression induced by endoplasmic_reticulum_stresses .
15573069	0	FR167653	65,73	p38	23,26	FR167653	p38	MESH:C104334	81649(Tax:10116)	Chemical	Gene	kinase|nmod|START_ENTITY kinase|amod|END_ENTITY	Specific inhibition of p38 mitogen-activated protein kinase with FR167653 attenuates vascular proliferation in monocrotaline-induced pulmonary_hypertension in rats .
18589173	0	FR167653	22,30	p38	78,81	FR167653	p38	MESH:C104334	81649(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY nephropathy|nsubj|effects nephropathy|advcl|inhibiting inhibiting|dobj|MAPK MAPK|amod|END_ENTITY	Protective effects of FR167653 on chronic allograft nephropathy by inhibiting p38 MAPK in rats .
26456460	0	FR171456	0,8	NSDHL	46,51	FR171456	NSDHL	MESH:C487953	50814	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	FR171456 is a specific inhibitor of mammalian NSDHL and yeast Erg26p .
10079013	0	FR173657	76,84	bradykinin_B2_receptor	41,63	FR173657	bradykinin B2 receptor	MESH:C105311	100135486(Tax:10141)	Chemical	Gene	Effects|appos|START_ENTITY Effects|nmod|antagonist antagonist|amod|END_ENTITY	Effects of the orally active non-peptide bradykinin_B2_receptor antagonist , FR173657 , on plasma extravasation in guinea_pig airways .
9051299	0	FR173657	86,94	bradykinin_B2_receptor	51,73	FR173657	bradykinin B2 receptor	MESH:C105311	100135486(Tax:10141)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	The identification of an orally active , nonpeptide bradykinin_B2_receptor antagonist , FR173657 .
17123065	0	FR180204	0,8	extracellular_signal-regulated_kinase	45,82	FR180204	extracellular signal-regulated kinase	MESH:C505241	26413(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	FR180204 , a novel and selective inhibitor of extracellular_signal-regulated_kinase , ameliorates collagen-induced_arthritis in mice .
11286400	0	FR188582	32,40	cyclooxygenase-2	74,90	FR188582	cyclooxygenase-2	MESH:C430892	29527(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|inhibitor inhibitor|nmod|END_ENTITY	The anti-inflammatory effect of FR188582 , a highly selective inhibitor of cyclooxygenase-2 , with an ulcerogenic sparing effect in rats .
17187252	0	FR202126	32,40	V-ATPase	12,20	FR202126	V-ATPase	MESH:C508362	242341(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Effect of a V-ATPase inhibitor , FR202126 , in syngeneic mouse model of experimental bone metastasis .
20227822	0	FR235222	30,38	Annexin_A1	124,134	FR235222	Annexin A1	MESH:C474179	301	Chemical	Gene	sensitizes|nsubj|START_ENTITY sensitizes|nmod|up-regulation up-regulation|nmod|END_ENTITY	Histone deacetylase inhibitor FR235222 sensitizes human prostate_adenocarcinoma cells to apoptosis through up-regulation of Annexin_A1 .
18295477	0	FR235222	11,19	annexin_A1	115,125	FR235222	annexin A1	MESH:C474179	301	Chemical	Gene	Effects|nmod|START_ENTITY Effects|dep|role role|nmod|END_ENTITY	Effects of FR235222 , a novel HDAC inhibitor , in proliferation and apoptosis of human leukaemia cell lines : role of annexin_A1 .
9794227	0	FR901228	18,26	c-Myc	36,41	FR901228	c-Myc	MESH:C087123	4609	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Fungal metabolite FR901228 inhibits c-Myc and Fas_ligand expression .
11443220	0	FR901228	71,79	histone_deacetylase	26,45	FR901228	histone deacetylase	MESH:C087123	9734	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Low concentrations of the histone_deacetylase inhibitor , depsipeptide -LRB- FR901228 -RRB- , increase expression of the Na -LRB- + -RRB- / I -LRB- - -RRB- _ symporter and iodine accumulation in poorly differentiated thyroid_carcinoma cells .
12569581	0	FR901228	63,71	histone_deacetylase	33,52	FR901228	histone deacetylase	MESH:C087123	9734	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Antiproliferative effects of the histone_deacetylase inhibitor FR901228 on small-cell_lung_cancer lines and drug-resistant sublines .
11929951	0	FR901228	91,99	p53	14,17	FR901228	p53	MESH:C087123	7157	Chemical	Gene	expression|nmod|START_ENTITY expression|nsubj|Modulation Modulation|nmod|END_ENTITY	Modulation of p53 , ErbB1 , ErbB2 , and Raf-1 expression in lung_cancer cells by depsipeptide FR901228 .
7844030	0	FR901451	0,8	human_leukocyte_elastase	31,55	FR901451	human leukocyte elastase	MESH:C091806	1991	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	FR901451 , a novel inhibitor of human_leukocyte_elastase from Flexibacter sp .
26774265	0	FRAX597	0,7	PAK1	11,15	FRAX597	PAK1	MESH:C584676	5058	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	FRAX597 , a PAK1 inhibitor , synergistically reduces pancreatic_cancer growth when combined with gemcitabine .
7509019	0	FRG-8813	53,61	mucin	74,79	FRG-8813	mucin	MESH:C076948	65202(Tax:10116)	Chemical	Gene	Effects|amod|START_ENTITY Effects|nmod|END_ENTITY	Effects of the new histamine H2 receptor antagonist , FRG-8813 , on gastric mucin in rats with or without acidified ethanol-induced gastric_damage .
8851171	0	FRG-8813	59,67	mucin	15,20	FRG-8813	mucin	MESH:C076948	65202(Tax:10116)	Chemical	Gene	mucosa|nmod|START_ENTITY biosynthesis|nmod|mucosa biosynthesis|nsubj|Stimulation Stimulation|nmod|END_ENTITY	Stimulation of mucin biosynthesis in rat gastric mucosa by FRG-8813 and its structural analogs .
26316589	0	FRUCTOSE	18,26	KHK	87,90	FRUCTOSE	KHK	MESH:D005632	25659(Tax:10116)	Chemical	Gene	EFFECT|nmod|START_ENTITY EFFECT|nmod|END_ENTITY	EFFECT OF DIETARY FRUCTOSE ON PORTAL AND SYSTEMIC SERUM FRUCTOSE LEVELS IN RATS AND IN KHK - / - AND GLUT5 - / - MICE .
26316589	0	FRUCTOSE	56,64	KHK	87,90	FRUCTOSE	KHK	MESH:D005632	25659(Tax:10116)	Chemical	Gene	LEVELS|compound|START_ENTITY FRUCTOSE|nmod|LEVELS EFFECT|nmod|FRUCTOSE EFFECT|nmod|END_ENTITY	EFFECT OF DIETARY FRUCTOSE ON PORTAL AND SYSTEMIC SERUM FRUCTOSE LEVELS IN RATS AND IN KHK - / - AND GLUT5 - / - MICE .
9095082	0	FR_173657	0,9	B2_receptor	43,54	FR 173657	B2 receptor	MESH:C105311	624	Chemical	Gene	START_ENTITY|dep|antagonist antagonist|amod|END_ENTITY	FR_173657 : a new , potent , nonpeptide kinin B2_receptor antagonist .
10596851	0	FR_173657	91,100	bradykinin_B2_receptor	32,54	FR 173657	bradykinin B2 receptor	MESH:C105311	100328963(Tax:9986)	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Characterization of non-peptide bradykinin_B2_receptor agonist -LRB- FR_190997 -RRB- and antagonist -LRB- FR_173657 -RRB- .
10596851	0	FR_190997	64,73	bradykinin_B2_receptor	32,54	FR 190997	bradykinin B2 receptor	MESH:C107104	100328963(Tax:9986)	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Characterization of non-peptide bradykinin_B2_receptor agonist -LRB- FR_190997 -RRB- and antagonist -LRB- FR_173657 -RRB- .
12700894	0	FTI-277	30,37	BDNF	96,100	FTI-277	BDNF	MESH:C096856	627	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|nmod|END_ENTITY	Farnesyltransferase inhibitor FTI-277 prevents autocrine growth stimulation of neuroblastoma by BDNF .
26587345	0	FTM080	29,35	Kisspeptin_receptor	0,19	FTM080	Kisspeptin receptor	null	100144753(Tax:9940)	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Kisspeptin_receptor agonist -LRB- FTM080 -RRB- increased plasma concentrations of luteinizing hormone in anestrous ewes .
22042694	0	FTY720	0,6	CD74	17,21	FTY720	CD74	MESH:C098720	972	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	FTY720 increases CD74 expression and sensitizes mantle_cell_lymphoma cells to milatuzumab-mediated cell death .
25843953	0	FTY720	0,6	DR5	58,61	FTY720	DR5	MESH:C098720	8795	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	FTY720 enhances TRAIL-mediated apoptosis by up-regulating DR5 and down-regulating Mcl-1 in cancer cells .
11950011	0	FTY720	11,17	MRL-lpr/lpr	21,32	FTY720	MRL-lpr/lpr	MESH:C098720	14102(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Effects of FTY720 in MRL-lpr/lpr mice : therapeutic potential in systemic_lupus_erythematosus .
22799042	0	FTY720	51,57	S1P1	29,33	FTY720	S1P1	MESH:C098720	13609(Tax:10090)	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Immunosuppressive effect of S1P1 receptor agonist FTY720 -RSB- .
21519925	0	FTY720	19,25	SREBP2	77,83	FTY720	SREBP2	MESH:C098720	6721	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|activating activating|dobj|END_ENTITY	Non-phosphorylated FTY720 induces apoptosis of human microglia by activating SREBP2 .
16093248	0	FTY720	73,79	Sphingosine_kinase_2	0,20	FTY720	Sphingosine kinase 2	MESH:C098720	56632(Tax:10090)	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Sphingosine_kinase_2 is required for modulation of lymphocyte traffic by FTY720 .
18378389	0	FTY720	23,29	autotaxin	62,71	FTY720	autotaxin	MESH:C098720	18606(Tax:10090)	Chemical	Gene	activity|nmod|START_ENTITY phosphorylated|nsubj|activity phosphorylated|ccomp|inhibits inhibits|dobj|END_ENTITY	Anticancer activity of FTY720 : phosphorylated FTY720 inhibits autotaxin , a metastasis-enhancing and angiogenic lysophospholipase D. FTY720 is an immunomodulator that is phosphorylated in vivo and inhibits lymphocyte mobilization by targeting sphingosine 1-phospate receptors .
18378389	0	FTY720	46,52	autotaxin	62,71	FTY720	autotaxin	MESH:C098720	18606(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Anticancer activity of FTY720 : phosphorylated FTY720 inhibits autotaxin , a metastasis-enhancing and angiogenic lysophospholipase D. FTY720 is an immunomodulator that is phosphorylated in vivo and inhibits lymphocyte mobilization by targeting sphingosine 1-phospate receptors .
20566326	0	FTY720	72,78	autotaxin	155,164	FTY720	autotaxin	MESH:C098720	84050(Tax:10116)	Chemical	Gene	analogue|nmod|START_ENTITY FTY720-vinylphosphonate|appos|analogue pan-antagonist|nsubj|FTY720-vinylphosphonate pan-antagonist|nmod|GPCR GPCR|acl|signaling signaling|dobj|activity activity|compound|END_ENTITY	-LRB- S -RRB- - FTY720-vinylphosphonate , an analogue of the immunosuppressive agent FTY720 , is a pan-antagonist of sphingosine_1-phosphate GPCR signaling and inhibits autotaxin activity .
17008548	0	FTY720	27,33	phospholipase_A2	53,69	FTY720	phospholipase A2	MESH:C098720	151056	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	The immunosuppressant drug FTY720 inhibits cytosolic phospholipase_A2 independently of sphingosine-1-phosphate receptors .
2303313	0	FUT-175	14,21	C4a	51,54	FUT-175	C4a	MESH:C032855	100356976(Tax:9986)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of FUT-175 -LRB- Nafamstat_Mesilate -RRB- on C3a , C4a and C5a generation in vitro and inflammatory reactions in vivo .
10440571	0	FUT-175	0,7	IL-6	35,39	FUT-175	IL-6	MESH:C032855	3569	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|nmod|END_ENTITY	FUT-175 inhibits the production of IL-6 and IL-8 in human monocytes .
8872815	0	FV_Q506	30,37	Factor_V_Leiden	0,15	FV Q506	Factor V Leiden	null	2153	Chemical	Gene	polymorphism|appos|START_ENTITY polymorphism|compound|END_ENTITY	Factor_V_Leiden polymorphism -LRB- FV_Q506 -RRB- in patients with ischaemic_heart_disease , and in different populations groups .
11562341	0	FXV673	65,71	factor_Xa	44,53	FXV673	factor Xa	MESH:C435830	2159	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Pharmacological characterization of a novel factor_Xa inhibitor , FXV673 .
15933230	0	FYX-051	68,75	xanthine_oxidoreductase	79,102	FYX-051	xanthine oxidoreductase	MESH:C504882	497811(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Simultaneous treatment with citrate prevents nephropathy induced by FYX-051 , a xanthine_oxidoreductase inhibitor , in rats .
17084874	0	FYX-051	107,114	xanthine_oxidoreductase	118,141	FYX-051	xanthine oxidoreductase	MESH:C504882	497811(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Strain differences in the responsiveness between Sprague-Dawley and Fischer rats to nephropathy induced by FYX-051 , a xanthine_oxidoreductase inhibitor .
17761779	0	FYX-051	108,115	xanthine_oxidoreductase	124,147	FYX-051	xanthine oxidoreductase	MESH:C504882	7498	Chemical	Gene	pyridine-2-carbonitrile|appos|START_ENTITY Characterization|dep|pyridine-2-carbonitrile Characterization|dep|END_ENTITY	Characterization of N-glucuronidation of 4 - -LRB- 5-pyridin-4-yl-1H - -LSB- 1,2,4 -RSB- triazol-3-yl -RRB- _ pyridine-2-carbonitrile -LRB- FYX-051 -RRB- : a new xanthine_oxidoreductase inhibitor .
19336671	0	FYX-051	0,7	xanthine_oxidoreductase	11,34	FYX-051	xanthine oxidoreductase	MESH:C504882	497811(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	FYX-051 , a xanthine_oxidoreductase inhibitor , induces nephropathy in rats , but not in monkeys .
19783139	0	FYX-051	65,72	xanthine_oxidoreductase	77,100	FYX-051	xanthine oxidoreductase	MESH:C504882	497811(Tax:10116)	Chemical	Gene	triazole|appos|START_ENTITY Discovery|dep|triazole Discovery|dep|inhibitor inhibitor|amod|END_ENTITY	Discovery of 3 - -LRB- 2-cyano-4-pyridyl -RRB- -5 - -LRB- 4-pyridyl -RRB- -1,2,4 - triazole , FYX-051 - a xanthine_oxidoreductase inhibitor for the treatment of hyperuricemia -LSB- corrected -RSB- .
20936465	0	FYX-051	55,62	xanthine_oxidoreductase	66,89	FYX-051	xanthine oxidoreductase	MESH:C504882	497811(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Study on species differences in nephropathy induced by FYX-051 , a xanthine_oxidoreductase inhibitor .
20952484	0	FYX-051	0,7	xanthine_oxidoreductase	53,76	FYX-051	xanthine oxidoreductase	MESH:C504882	497811(Tax:10116)	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	FYX-051 : a novel and potent hybrid-type inhibitor of xanthine_oxidoreductase .
21105859	0	FYX-051	97,104	xanthine_oxidoreductase	108,131	FYX-051	xanthine oxidoreductase	MESH:C504882	497811(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Establishment of simultaneous treatment model with citrate for preventing nephropathy induced by FYX-051 , a xanthine_oxidoreductase inhibitor , in rats .
21314469	0	FYX-051	77,84	xanthine_oxidoreductase	88,111	FYX-051	xanthine oxidoreductase	MESH:C504882	497811(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Study on toxicological aspects of crystal-mediated nephrotoxicity induced by FYX-051 , a xanthine_oxidoreductase inhibitor , in rats .
2570079	0	F_101468	192,200	dopamine_D2_receptor	204,224	F 101468	dopamine D2 receptor	null	1813	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Application of thermospray liquid chromatography-mass spectrometry and liquid chromatography-tandem mass spectrometry for the identification of cynomolgus_monkey and human metabolites of SK _ F_101468 , a dopamine_D2_receptor agonist .
10381763	0	F_11356	0,7	5-HT1B	117,123	F 11356	5-HT1B	MESH:C120143	3351	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	F_11356 , a novel 5-hydroxytryptamine -LRB- 5-HT -RRB- derivative with potent , selective , and unique high intrinsic activity at 5-HT1B / 1D receptors in models relevant to migraine .
9765347	0	F_11440	0,7	5-HT1A_receptor	44,59	F 11440	5-HT1A receptor	MESH:C115127	3350	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	F_11440 , a potent , selective , high efficacy 5-HT1A_receptor agonist with marked anxiolytic and antidepressant potential .
12742639	0	F_13640	63,70	c-Fos	79,84	F 13640	c-Fos	MESH:C473959	314322(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	The novel analgesic and high-efficacy 5-HT1A receptor agonist , F_13640 induces c-Fos protein expression in spinal cord dorsal horn neurons .
15910798	0	F_13640	54,61	c-Fos	92,97	F 13640	c-Fos	MESH:C473959	314322(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY Effects|nmod|agonist Effects|dep|study study|amod|END_ENTITY	Effects of the high-efficacy 5-HT1A receptor agonist , F_13640 in the formalin pain model : a c-Fos study .
19344702	0	F_16618	34,41	PAR1	17,21	F 16618	PAR1	MESH:C542252	25439(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	Effects of a new PAR1 antagonist , F_16618 , on smooth muscle cell contraction .
20188709	0	F_16618	27,34	PAR1	42,46	F 16618	PAR1	MESH:C542252	25439(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Antithrombotic activity of F_16618 , a new PAR1 antagonist evaluated in extracorporeal arterio-venous shunt in the rat .
6132343	0	F_64139	22,29	phenylethanolamine-N-methyltransferase	33,71	F 64139	phenylethanolamine-N-methyltransferase	null	24661(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	The influence of SK _ F_64139 , a phenylethanolamine-N-methyltransferase inhibitor , on centrally mediated cardiovascular effects of alpha-methyldopa and clonidine .
20206138	0	Falcarinol	0,10	CB1	37,40	Falcarinol	CB1	MESH:C018541	1268	Chemical	Gene	antagonist|nsubj|START_ENTITY antagonist|compound|END_ENTITY	Falcarinol is a covalent cannabinoid CB1 receptor antagonist and induces pro-allergic effects in skin .
22512725	0	Famotidine	0,10	glycogen_synthase_kinase-3b	20,47	Famotidine	glycogen synthase kinase-3b	MESH:D015738	2932	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Famotidine inhibits glycogen_synthase_kinase-3b : an investigation by docking simulation and experimental validation .
25872479	0	Fangchinoline	0,13	PI3K	22,26	Fangchinoline	PI3K	MESH:C060802	5293	Chemical	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	Fangchinoline targets PI3K and suppresses PI3K/AKT signaling pathway in SGC7901 cells .
25872479	0	Fangchinoline	0,13	PI3K	22,26	Fangchinoline	PI3K	MESH:C060802	5293	Chemical	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	Fangchinoline targets PI3K and suppresses PI3K/AKT signaling pathway in SGC7901 cells .
16540091	0	Farnesol	0,8	beta1	48,53	Farnesol	beta1	MESH:D005204	3779	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Farnesol induces thyroid hormone receptor -LRB- THR -RRB- beta1 but inhibits THR-mediated signaling in MCF-7 human breast_cancer cells .
7646076	0	Farnesyl_pyrophosphate	0,22	lupin	43,48	Farnesyl pyrophosphate	lupin	MESH:C004808	51251	Chemical	Gene	synthase|amod|START_ENTITY synthase|nmod|END_ENTITY	Farnesyl_pyrophosphate synthase from white lupin : molecular cloning , expression , and purification of the expressed protein .
21500191	0	Farnesylthiosalicylic_acid	0,26	Rheb	48,52	Farnesylthiosalicylic acid	Rheb	MESH:C093323	6009	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Farnesylthiosalicylic_acid -LRB- salirasib -RRB- inhibits Rheb in TSC2-null ELT3 cells : a potential treatment for lymphangioleiomyomatosis .
15459249	0	Farnesylthiosalicylic_acid	0,26	mammalian_target_of_rapamycin	36,65	Farnesylthiosalicylic acid	mammalian target of rapamycin	MESH:C093323	2475	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Farnesylthiosalicylic_acid inhibits mammalian_target_of_rapamycin -LRB- mTOR -RRB- activity both in cells and in vitro by promoting dissociation of the mTOR-raptor complex .
15957161	0	Farnesylthiosalicylic_acid	0,26	mammalian_target_of_rapamycin	34,63	Farnesylthiosalicylic acid	mammalian target of rapamycin	MESH:C093323	2475	Chemical	Gene	blocks|amod|START_ENTITY END_ENTITY|nsubj|blocks	Farnesylthiosalicylic_acid blocks mammalian_target_of_rapamycin signaling in breast_cancer cells .
26615574	0	Farrerol	0,8	IL-6	18,22	Farrerol	IL-6	MESH:C015881	3569	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Farrerol inhibits IL-6 and IL-8 production in LPS-stimulated human gingival fibroblasts by suppressing PI3K/AKT/NF-kB signaling pathway .
24726849	0	Farrerol	0,8	occludin	19,27	Farrerol	occludin	MESH:C015881	100506658	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Farrerol regulates occludin expression in hydrogen_peroxide-induced EA.hy926 cells by modulating ERK1/2 activity .
16816972	0	Fascaplysin	0,11	CDK4	25,29	Fascaplysin	CDK4	null	1019	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Fascaplysin , a selective CDK4 inhibitor , exhibit anti-angiogenic activity in vitro and in vivo .
24905175	0	Fasudil	0,7	GFAP	16,20	Fasudil	GFAP	MESH:C049347	2670	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|compound|END_ENTITY	Fasudil reduces GFAP expression after hypoxic_injury .
17122957	0	Fasudil	0,7	Rho-kinase	11,21	Fasudil	Rho-kinase	MESH:C049347	19878(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Fasudil , a Rho-kinase inhibitor , inhibits leukocyte adhesion in inflamed large blood vessels in vivo .
21126559	0	Fasudil	0,7	Rho-kinase	119,129	Fasudil	Rho-kinase	MESH:C049347	19878(Tax:10090)	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|inhibition inhibition|nmod|END_ENTITY	Fasudil protects cultured N1E-115 cells against lysophosphatidic_acid-induced neurite retraction through inhibition of Rho-kinase .
24405591	0	Fasudil	15,22	TNF-a	53,58	Fasudil	TNF-a	MESH:C049347	21926(Tax:10090)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	-LSB- Inhibition of Fasudil on lipopolysaccharide-induced TNF-a and IL-1b expressions through TLR4 pathway in murine_BV-2 cells in vitro -RSB- .
22942703	0	Fasudil	0,7	rho-kinase	11,21	Fasudil	rho-kinase	MESH:C049347	19878(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Fasudil , a rho-kinase inhibitor , attenuates bleomycin-induced pulmonary_fibrosis in mice .
24348024	0	Fatty_Acid	42,52	CD36	98,102	Fatty Acid	CD36	CHEBI:35366	948	Chemical	Gene	Site|compound|START_ENTITY Prediction|nmod|Site Prediction|nmod|END_ENTITY	Three Dimensional Structure Prediction of Fatty_Acid Binding Site on Human Transmembrane Receptor CD36 .
25555908	0	Fatty_Acid	80,90	CD36	0,4	Fatty Acid	CD36	CHEBI:35366	948	Chemical	Gene	Binding|compound|START_ENTITY Oxidized|nmod|Binding Oxidized|nsubj|Binds Binds|compound|END_ENTITY	CD36 Binds Oxidized Low Density Lipoprotein -LRB- LDL -RRB- in a Mechanism Dependent upon Fatty_Acid Binding .
25049644	0	Fatty_Acid	129,139	FABP4	122,127	Fatty Acid	FABP4	CHEBI:35366	281759(Tax:9913)	Chemical	Gene	Protein|compound|START_ENTITY END_ENTITY|dep|Protein	Identification of the SNP -LRB- Single Nucleotide Polymorphism -RRB- for Fatty_Acid Composition Associated with Beef Flavor-related FABP4 -LRB- Fatty_Acid Binding Protein 4 -RRB- in Korean Cattle .
25049644	0	Fatty_Acid	63,73	FABP4	122,127	Fatty Acid	FABP4	CHEBI:35366	281759(Tax:9913)	Chemical	Gene	Associated|compound|START_ENTITY Associated|nmod|END_ENTITY	Identification of the SNP -LRB- Single Nucleotide Polymorphism -RRB- for Fatty_Acid Composition Associated with Beef Flavor-related FABP4 -LRB- Fatty_Acid Binding Protein 4 -RRB- in Korean Cattle .
26752184	0	Fatty_Acid	22,32	FABP4	50,55	Fatty Acid	FABP4	CHEBI:35366	2167	Chemical	Gene	Protein|compound|START_ENTITY Protein|appos|END_ENTITY	Circulating Adipocyte Fatty_Acid Binding Protein -LRB- FABP4 -RRB- Levels Are Associated with Irisin in the Middle-Aged General Chinese Population .
26020772	0	Fatty_Acid	9,19	FABP5	39,44	Fatty Acid	FABP5	CHEBI:35366	2171	Chemical	Gene	Protein|compound|START_ENTITY Level|nmod|Protein Level|appos|END_ENTITY	Level of Fatty_Acid Binding Protein 5 -LRB- FABP5 -RRB- Is Increased in Sputum of Allergic Asthmatics and Links to Airway Remodeling and Inflammation .
26020772	0	Fatty_Acid	9,19	FABP5	39,44	Fatty Acid	FABP5	CHEBI:35366	2171	Chemical	Gene	Protein|compound|START_ENTITY Level|nmod|Protein Level|appos|END_ENTITY	Level of Fatty_Acid Binding Protein 5 -LRB- FABP5 -RRB- Is Increased in Sputum of Allergic Asthmatics and Links to Airway Remodeling and Inflammation .
25386691	0	Fatty_Acid	18,28	FAD2	72,76	Fatty Acid	FAD2	CHEBI:35366	105163532	Chemical	Gene	Composition|compound|START_ENTITY Composition|nmod|Region Region|compound|END_ENTITY	Variation in Seed Fatty_Acid Composition and Sequence Divergence in the FAD2 Gene Coding Region between Wild and Cultivated Sesame .
24705214	0	Fatty_Acid	17,27	FADS	40,44	Fatty Acid	FADS	CHEBI:35366	6319	Chemical	Gene	Desaturase|compound|START_ENTITY Desaturase|appos|END_ENTITY	Polymorphisms in Fatty_Acid Desaturase -LRB- FADS -RRB- Gene Cluster : Effects on Glycemic Controls Following an Omega-3 Polyunsaturated Fatty_Acids -LRB- PUFA -RRB- Supplementation .
24977108	0	Fatty_Acid	80,90	FADS	24,28	Fatty Acid	FADS	CHEBI:35366	6319	Chemical	Gene	Intake|compound|START_ENTITY Recommendations|nmod|Intake Implications|nmod|Recommendations Variants|dep|Implications Variants|nmod|Gene Gene|compound|END_ENTITY	Genetic Variants in the FADS Gene : Implications for Dietary Recommendations for Fatty_Acid Intake .
26633493	0	Fatty_Acid	123,133	FADS	39,43	Fatty Acid	FADS	CHEBI:35366	4593	Chemical	Gene	Composition|compound|START_ENTITY Associated|nmod|Composition Associated|nsubj|Polymorphisms Polymorphisms|nmod|Cluster Cluster|compound|END_ENTITY	Single Nucleotide Polymorphisms in the FADS Gene Cluster but not the ELOVL2 Gene are Associated with Serum Polyunsaturated Fatty_Acid Composition and Development of Allergy -LRB- in a Swedish Birth Cohort -RRB- .
25655684	0	Fatty_Acid	30,40	FASN	51,55	Fatty Acid	FASN	CHEBI:35366	14104(Tax:10090)	Chemical	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	TSH/TSHR Signaling Suppresses Fatty_Acid Synthase -LRB- FASN -RRB- Expression in Adipocytes .
22837665	0	Fatty_Acid	62,72	FATP4	94,99	Fatty Acid	FATP4	CHEBI:35366	417220(Tax:9031)	Chemical	Gene	Protein|compound|START_ENTITY Pattern|nmod|Protein Pattern|appos|END_ENTITY	Ontogenic Expression Pattern and Genetic Polymorphisms of the Fatty_Acid Transport Protein 4 -LRB- FATP4 -RRB- Gene in Chinese Chicken Populations .
25883112	0	Fatty_Acid	20,30	Insulin	60,67	Fatty Acid	Insulin	CHEBI:35366	3630	Chemical	Gene	Storage|compound|START_ENTITY Storage|dep|Effects Effects|nmod|Control Control|compound|END_ENTITY	Adipose Tissue Free Fatty_Acid Storage in vivo - Effects of Insulin versus Niacin as a Control for Suppression of Lipolysis .
26629522	0	Fatty_Acid	28,38	Insulin	86,93	Fatty Acid	Insulin	CHEBI:35366	3630	Chemical	Gene	Profile|compound|START_ENTITY Relationship|nmod|Profile Relationship|nmod|Resistance Resistance|compound|END_ENTITY	Relationship of Circulating Fatty_Acid Profile to Metabolic_Disorders Associated with Insulin Resistance .
26752184	0	Fatty_Acid	22,32	Irisin	84,90	Fatty Acid	Irisin	CHEBI:35366	252995	Chemical	Gene	Protein|compound|START_ENTITY Levels|nsubj|Protein Levels|dobj|Associated Associated|nmod|END_ENTITY	Circulating Adipocyte Fatty_Acid Binding Protein -LRB- FABP4 -RRB- Levels Are Associated with Irisin in the Middle-Aged General Chinese Population .
23533380	0	Fatty_Acid	14,24	L-FABP	112,118	Fatty Acid	L-FABP	CHEBI:35366	14080(Tax:10090)	Chemical	Gene	PPAR_a|compound|START_ENTITY Inhibitors|nmod|PPAR_a Inhibitors|dep|Genes Genes|dep|Roles Roles|nmod|END_ENTITY	Inhibitors of Fatty_Acid Synthesis Induce PPAR_a - Regulated Fatty_Acid b - Oxidative Genes : Synergistic Roles of L-FABP and Glucose .
23533380	0	Fatty_Acid	60,70	L-FABP	112,118	Fatty Acid	L-FABP	CHEBI:35366	14080(Tax:10090)	Chemical	Gene	Inhibitors|dep|START_ENTITY Inhibitors|dep|Genes Genes|dep|Roles Roles|nmod|END_ENTITY	Inhibitors of Fatty_Acid Synthesis Induce PPAR_a - Regulated Fatty_Acid b - Oxidative Genes : Synergistic Roles of L-FABP and Glucose .
25501331	0	Fatty_Acid	70,80	Lipoprotein_lipase	0,18	Fatty Acid	Lipoprotein lipase	CHEBI:35366	100860750	Chemical	Gene	synthesis|compound|START_ENTITY related|nmod|synthesis related|advmod|END_ENTITY	Lipoprotein_lipase , tissue expression and effects on genes related to Fatty_Acid synthesis in goat mammary epithelial cells .
25753425	0	Fatty_Acid	32,42	M-CSF	0,5	Fatty Acid	M-CSF	CHEBI:35366	12977(Tax:10090)	Chemical	Gene	Synthase|compound|START_ENTITY END_ENTITY|nmod|Synthase	M-CSF from Cancer Cells Induces Fatty_Acid Synthase and PPARb / Activation in Tumor Myeloid Cells , Leading to Tumor Progression .
25049536	0	Fatty_Acid	54,64	Milk	76,80	Fatty Acid	Milk	CHEBI:35366	100532204	Chemical	Gene	Profile|compound|START_ENTITY Mobilization|nmod|Profile Effect|nmod|Mobilization Effect|nmod|END_ENTITY	The Effect of Body Energy Reserve Mobilization on the Fatty_Acid Profile of Milk in High-yielding Cows .
25049969	0	Fatty_Acid	32,42	Milk	87,91	Fatty Acid	Milk	CHEBI:35366	100532204	Chemical	Gene	START_ENTITY|nmod|Expression Expression|nmod|Associated Associated|nmod|Fat Fat|compound|END_ENTITY	Effects of Saturated Long-chain Fatty_Acid on mRNA Expression of Genes Associated with Milk Fat and Protein Biosynthesis in Bovine Mammary Epithelial Cells .
26305244	0	Fatty_Acid	0,10	Milk	22,26	Fatty Acid	Milk	CHEBI:35366	100532204	Chemical	Gene	Profile|compound|START_ENTITY Profile|nmod|END_ENTITY	Fatty_Acid Profile of Milk and Cheese from Dairy Cows Supplemented a Diet with Palm Kernel Cake .
26305244	0	Fatty_Acid	0,10	Milk	22,26	Fatty Acid	Milk	CHEBI:35366	100532204	Chemical	Gene	Profile|compound|START_ENTITY Profile|nmod|END_ENTITY	Fatty_Acid Profile of Milk and Cheese from Dairy Cows Supplemented a Diet with Palm Kernel Cake .
26444286	0	Fatty_Acid	20,30	Milk	42,46	Fatty Acid	Milk	CHEBI:35366	100532204	Chemical	Gene	Profile|compound|START_ENTITY Profile|nmod|END_ENTITY	Kefir Grains Change Fatty_Acid Profile of Milk during Fermentation and Storage .
26336578	0	Fatty_Acid	64,74	OATP1B1	37,44	Fatty Acid	OATP1B1	CHEBI:35366	10599	Chemical	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	Role of miR-511 in the Regulation of OATP1B1 Expression by Free Fatty_Acid .
23533380	0	Fatty_Acid	60,70	PPAR_a	42,48	Fatty Acid	PPAR a	CHEBI:35366	19013(Tax:10090)	Chemical	Gene	Inhibitors|dep|START_ENTITY Inhibitors|nmod|END_ENTITY	Inhibitors of Fatty_Acid Synthesis Induce PPAR_a - Regulated Fatty_Acid b - Oxidative Genes : Synergistic Roles of L-FABP and Glucose .
26875495	0	Fatty_Acid	20,30	Peroxisome_Proliferator-Activated_Receptor_a	70,114	Fatty Acid	Peroxisome Proliferator-Activated Receptor a	CHEBI:35366	19013(Tax:10090)	Chemical	Gene	Oxidation|compound|START_ENTITY Oxidation|nmod|Up-Regulation Up-Regulation|nmod|END_ENTITY	Propionate Promotes Fatty_Acid Oxidation through the Up-Regulation of Peroxisome_Proliferator-Activated_Receptor_a in Intestinal Epithelial Cells .
23825152	0	Fatty_Acid	90,100	Resistin	61,69	Fatty Acid	Resistin	CHEBI:35366	246250(Tax:10116)	Chemical	Gene	Composition|compound|START_ENTITY Composition|compound|END_ENTITY	Anthocyanin-Rich Juice Lowers Serum Cholesterol , Leptin , and Resistin and Improves Plasma Fatty_Acid Composition in Fischer Rats .
26789108	0	Fatty_Acid	8,18	SIRT3	95,100	Fatty Acid	SIRT3	CHEBI:35366	64384(Tax:10090)	Chemical	Gene	4/aP2|compound|START_ENTITY Loss|nmod|4/aP2 Reduces|nsubj|Loss Reduces|xcomp|Inflammation Inflammation|dep|Activation Activation|nmod|END_ENTITY	Loss of Fatty_Acid Binding Protein 4/aP2 Reduces Macrophage Inflammation Through Activation of SIRT3 .
26427794	0	Fatty_Acid	42,52	miR-33	26,32	Fatty Acid	miR-33	CHEBI:35366	723897(Tax:10090)	Chemical	Gene	Oxidation|compound|START_ENTITY Oxidation|amod|END_ENTITY	Therapeutic Inhibition of miR-33 Promotes Fatty_Acid Oxidation but Does Not Ameliorate Metabolic Dysfunction in Diet-Induced Obesity .
25143856	0	Fatty_Acid	0,10	ren	90,93	Fatty Acid	ren	CHEBI:35366	100544109	Chemical	Gene	composition|amod|START_ENTITY END_ENTITY|nsubj|composition	Fatty_Acid composition of the muscle_lipids of five fish species in i kl and karaca ren dam lake , Turkey .
22639704	0	Fatty_Acid_Amide	38,54	FAAH	66,70	Fatty Acid Amide	FAAH	null	2166	Chemical	Gene	Hydrolase|compound|START_ENTITY Hydrolase|appos|END_ENTITY	a-Ketoheterocycle-based Inhibitors of Fatty_Acid_Amide Hydrolase -LRB- FAAH -RRB- .
26593700	0	Fatty_Acid_Amide	29,45	FAAH	57,61	Fatty Acid Amide	FAAH	null	2166	Chemical	Gene	Hydrolase|compound|START_ENTITY Hydrolase|appos|END_ENTITY	The Molecular Basis for Dual Fatty_Acid_Amide Hydrolase -LRB- FAAH -RRB- / Cyclooxygenase -LRB- COX -RRB- Inhibition .
26632945	0	Fatty_Acid_Propyl_Esters	23,47	Aid	76,79	Fatty Acid Propyl Esters	Aid	null	57379	Chemical	Gene	START_ENTITY|nmod|Analysis Analysis|nmod|END_ENTITY	Assignment of Milk Fat Fatty_Acid_Propyl_Esters by GC-FID Analysis with the Aid of Ag-ion Solid-phase Extraction .
26423681	0	Fatty_Acids	11,22	CYP2A5	26,32	Fatty Acids	CYP2A5	MESH:D005227	13087(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|Expression Expression|compound|END_ENTITY	Effects of Fatty_Acids on CYP2A5 and Nrf2 Expression in Mouse Primary Hepatocytes .
26725438	0	Fatty_Acids	37,48	PPAR	128,132	Fatty Acids	PPAR	MESH:D005227	19013(Tax:10090)	Chemical	Gene	Metabolism|nmod|START_ENTITY Metabolism|appos|END_ENTITY	Boiogito Increases the Metabolism of Fatty_Acids in Proximal Tubular Cells through Peroxisome_Proliferators-Activated_Receptor -LRB- PPAR -RRB- a Agonistic Activity .
26725438	0	Fatty_Acids	37,48	Peroxisome_Proliferators-Activated_Receptor	83,126	Fatty Acids	Peroxisome Proliferators-Activated Receptor	MESH:D005227	19013(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|Cells Cells|nmod|END_ENTITY	Boiogito Increases the Metabolism of Fatty_Acids in Proximal Tubular Cells through Peroxisome_Proliferators-Activated_Receptor -LRB- PPAR -RRB- a Agonistic Activity .
26599760	0	Fatty_Acids	30,41	Sterol_Regulatory_Element-Binding_Protein1	64,106	Fatty Acids	Sterol Regulatory Element-Binding Protein1	MESH:D005227	539361(Tax:9913)	Chemical	Gene	Mediated|compound|START_ENTITY Mediated|nmod|END_ENTITY	b-Hydroxybutyrate Facilitates Fatty_Acids Synthesis Mediated by Sterol_Regulatory_Element-Binding_Protein1 in Bovine Mammary Epithelial Cells .
17904092	0	Fatty_acid	0,10	CD36	94,98	Fatty acid	CD36	CHEBI:35366	12491(Tax:10090)	Chemical	Gene	oxidation|amod|START_ENTITY unaffected|nsubj|oxidation unaffected|nmod|deletion deletion|nmod|END_ENTITY	Fatty_acid oxidation in cardiac_and_skeletal_muscle mitochondria is unaffected by deletion of CD36 .
21147770	0	Fatty_acid	0,10	CD36	121,125	Fatty acid	CD36	CHEBI:35366	12491(Tax:10090)	Chemical	Gene	transport|amod|START_ENTITY unbound|nsubj|transport unbound|ccomp|mediated mediated|nmod|pump pump|acl|modulated modulated|nmod|protein protein|compound|END_ENTITY	Fatty_acid -LRB- FFA -RRB- transport in cardiomyocytes revealed by imaging unbound FFA is mediated by an FFA pump modulated by the CD36 protein .
26070408	0	Fatty_acid	0,10	FABP4	30,35	Fatty acid	FABP4	CHEBI:35366	11770(Tax:10090)	Chemical	Gene	protein-4|amod|START_ENTITY protein-4|appos|END_ENTITY	Fatty_acid binding protein-4 -LRB- FABP4 -RRB- is a hypoxia inducible gene that sensitizes mice to liver_ischemia / reperfusion injury .
10638339	0	Fatty_acid	0,10	FABPpm	25,31	Fatty acid	FABPpm	CHEBI:35366	2806	Chemical	Gene	transporters|amod|START_ENTITY transporters|appos|END_ENTITY	Fatty_acid transporters -LRB- FABPpm , FAT , FATP -RRB- in human muscle .
21513558	0	Fatty_acid	0,10	FADS	23,27	Fatty acid	FADS	CHEBI:35366	6319	Chemical	Gene	polymorphisms|amod|START_ENTITY polymorphisms|appos|END_ENTITY	Fatty_acid desaturase -LRB- FADS -RRB- gene polymorphisms and insulin resistance in association with serum phospholipid polyunsaturated_fatty_acid composition in healthy Korean men : cross-sectional study .
10228495	0	Fatty_acid	0,10	FAS	21,24	Fatty acid	FAS	CHEBI:35366	2194	Chemical	Gene	synthase|nsubj|START_ENTITY synthase|dobj|strength strength|appos|END_ENTITY	Fatty_acid synthase -LRB- FAS -RRB- predictive strength in poorly differentiated early breast_carcinomas .
11323104	0	Fatty_acid	0,10	FAS	21,24	Fatty acid	FAS	CHEBI:35366	2194	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	Fatty_acid synthase -LRB- FAS -RRB- expression in human breast_cancer cell culture supernatants and in breast_cancer patients .
15736468	0	Fatty_acid	0,10	FAS	21,24	Fatty acid	FAS	CHEBI:35366	2194	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	Fatty_acid synthase -LRB- FAS -RRB- is a marker of increased risk of recurrence in lung_carcinoma .
8631008	0	Fatty_acid	0,10	FAS	21,24	Fatty acid	FAS	CHEBI:35366	2194	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	Fatty_acid synthase -LRB- FAS -RRB- : a target for cytotoxic antimetabolites in HL60 promyelocytic_leukemia cells .
21773945	0	Fatty_acid	0,10	FASN	98,102	Fatty acid	FASN	CHEBI:35366	281152(Tax:9913)	Chemical	Gene	composition|amod|START_ENTITY associated|nsubjpass|composition associated|nmod|variants variants|nmod|END_ENTITY	Fatty_acid composition of beef is associated with exonic nucleotide variants of the gene encoding FASN .
24430360	0	Fatty_acid	0,10	FASN	21,25	Fatty acid	FASN	CHEBI:35366	2194	Chemical	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Fatty_acid synthase -LRB- FASN -RRB- levels in serum of colorectal_cancer patients : correlation with clinical outcomes .
10638339	0	Fatty_acid	0,10	FAT	33,36	Fatty acid	FAT	CHEBI:35366	948	Chemical	Gene	transporters|amod|START_ENTITY transporters|appos|FABPpm FABPpm|dep|END_ENTITY	Fatty_acid transporters -LRB- FABPpm , FAT , FATP -RRB- in human muscle .
15677505	0	Fatty_acid	0,10	FAT/CD36	24,32	Fatty acid	FAT/CD36	CHEBI:35366	948	Chemical	Gene	translocase|amod|START_ENTITY translocase|appos|END_ENTITY	Fatty_acid translocase -LRB- FAT/CD36 -RRB- is localized on insulin-containing granules in human pancreatic beta-cells and mediates fatty_acid effects on insulin secretion .
10638339	0	Fatty_acid	0,10	FATP	38,42	Fatty acid	FATP	CHEBI:35366	376497	Chemical	Gene	transporters|amod|START_ENTITY transporters|appos|FABPpm FABPpm|dep|END_ENTITY	Fatty_acid transporters -LRB- FABPpm , FAT , FATP -RRB- in human muscle .
16925585	0	Fatty_acid	0,10	Rv2212	42,48	Fatty acid	Rv2212	CHEBI:35366	887979(Tax:83332)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Fatty_acid regulation of adenylyl cyclase Rv2212 from Mycobacterium_tuberculosis_H37Rv .
25127353	0	Fatty_acid	0,10	UCP2	32,36	Fatty acid	UCP2	CHEBI:35366	7351	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Fatty_acid flippase activity of UCP2 is essential for its proton transport in mitochondria .
21244856	0	Fatty_acid	0,10	Wnt1	27,31	Fatty acid	Wnt1	CHEBI:35366	7471	Chemical	Gene	modification|amod|START_ENTITY modification|nmod|END_ENTITY	Fatty_acid modification of Wnt1 and Wnt3a at serine is prerequisite for lipidation at cysteine and is essential for Wnt signalling .
1862684	0	Fatty_acid	0,10	albumin	28,35	Fatty acid	albumin	CHEBI:35366	213	Chemical	Gene	START_ENTITY|xcomp|binding binding|xcomp|serum serum|dobj|END_ENTITY	Fatty_acid binding to serum albumin in type I_insulin-dependent_diabetes_mellitus .
26048999	0	Fatty_acid	0,10	albumin	65,72	Fatty acid	albumin	CHEBI:35366	213	Chemical	Gene	START_ENTITY|nmod|site site|nmod|END_ENTITY	Fatty_acid binding into the highest affinity site of human serum albumin observed in molecular dynamics simulation .
6995332	0	Fatty_acid	0,10	albumin	34,41	Fatty acid	albumin	CHEBI:35366	213	Chemical	Gene	sites|amod|START_ENTITY sites|nmod|END_ENTITY	Fatty_acid binding sites of serum albumin as membrane receptor analogs for streptococcal lipoteichoic_acid .
12021372	0	Fatty_acid	0,10	coxsackievirus_and_adenovirus_receptor	31,69	Fatty acid	coxsackievirus and adenovirus receptor	CHEBI:35366	1525	Chemical	Gene	modification|amod|START_ENTITY modification|nmod|END_ENTITY	Fatty_acid modification of the coxsackievirus_and_adenovirus_receptor .
8386433	0	Fatty_acid	0,10	delta-6-desaturase	57,75	Fatty acid	delta-6-desaturase	CHEBI:35366	9415	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|dep|role role|nmod|END_ENTITY	Fatty_acid metabolism in health and disease : the role of delta-6-desaturase .
14969504	0	Fatty_acid	0,10	fats	26,30	Fatty acid	fats	CHEBI:35366	118611	Chemical	Gene	composition|amod|START_ENTITY composition|nmod|END_ENTITY	Fatty_acid composition of fats is an early determinant of childhood obesity : a short review and an opinion .
11734578	0	Fatty_acid	0,10	hormone-sensitive_lipase	26,50	Fatty acid	hormone-sensitive lipase	CHEBI:35366	25330(Tax:10116)	Chemical	Gene	specificity|amod|START_ENTITY specificity|nmod|END_ENTITY	Fatty_acid specificity of hormone-sensitive_lipase .
11925664	0	Fatty_acid	1,11	insulin	65,72	Fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	composition|compound|START_ENTITY composition|nmod|END_ENTITY	-LSB- Fatty_acid composition of serum phospholipids and the effect of insulin in patients with type 2 diabetes -RSB- .
15256315	0	Fatty_acid	0,10	insulin	66,73	Fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	composition|amod|START_ENTITY related|nsubjpass|composition related|nmod|levels levels|compound|END_ENTITY	Fatty_acid composition of erythrocyte phospholipids is related to insulin levels , secretion and resistance in obese_type_2 diabetics on Metformin .
18269178	0	Fatty_acid	0,10	insulin	58,65	Fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	transport|amod|START_ENTITY transport|nmod|resistance resistance|compound|END_ENTITY	Fatty_acid transport in adipocytes and the development of insulin resistance .
19181734	0	Fatty_acid	0,10	insulin	38,45	Fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	synthase|amod|START_ENTITY synthase|dep|association association|nmod|resistance resistance|compound|END_ENTITY	Fatty_acid synthase : association with insulin resistance , type 2 diabetes , and cancer .
11832362	0	Fatty_acid	0,10	leptin	79,85	Fatty acid	leptin	CHEBI:35366	25608(Tax:10116)	Chemical	Gene	oxidation|amod|START_ENTITY enhanced|nsubjpass|oxidation enhanced|nmod|treatment treatment|compound|END_ENTITY	Fatty_acid oxidation and triacylglycerol hydrolysis are enhanced after chronic leptin treatment in rats .
2300584	0	Fatty_acid	0,10	lipoprotein_lipase	22,40	Fatty acid	lipoprotein lipase	CHEBI:35366	280843(Tax:9913)	Chemical	Gene	control|amod|START_ENTITY control|nmod|END_ENTITY	Fatty_acid control of lipoprotein_lipase : a link between energy metabolism and lipid transport .
9565883	0	Fatty_acid	0,10	milk	26,30	Fatty acid	milk	CHEBI:35366	100532204	Chemical	Gene	composition|amod|START_ENTITY composition|nmod|END_ENTITY	Fatty_acid composition of milk from Holstein cows fed oleamide or canola oil .
7980870	0	Fatty_acid	0,10	myoglobin	22,31	Fatty acid	myoglobin	CHEBI:35366	418056(Tax:9031)	Chemical	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	Fatty_acid binding of myoglobin depends on its oxygenation .
7626496	0	Fatty_acid	0,10	peroxisome_proliferator-activated_receptor	25,67	Fatty acid	peroxisome proliferator-activated receptor	CHEBI:35366	5465	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Fatty_acid activation of peroxisome_proliferator-activated_receptor -LRB- PPAR -RRB- .
9070252	0	Fatty_acid_sulfonyl_fluorides	0,29	cannabinoid_receptor	76,96	Fatty acid sulfonyl fluorides	cannabinoid receptor	null	1268	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|nmod|END_ENTITY	Fatty_acid_sulfonyl_fluorides inhibit anandamide metabolism and bind to the cannabinoid_receptor .
1753215	1	Fatty_acids	47,58	aP2	79,82	Fatty acids	aP2	MESH:D005227	7020	Chemical	Gene	inducers|nsubj|START_ENTITY inducers|nmod|expression expression|amod|END_ENTITY	I. Fatty_acids are inducers of the aP2 gene expression .
2451542	0	Fatty_acids	0,11	alpha-fetoprotein	21,38	Fatty acids	alpha-fetoprotein	MESH:D005227	24177(Tax:10116)	Chemical	Gene	bound|nsubj|START_ENTITY bound|nmod|END_ENTITY	Fatty_acids bound to alpha-fetoprotein and albumin during rat development .
19843871	0	Fatty_acids	0,11	amylin	19,25	Fatty acids	amylin	MESH:D005227	15874(Tax:10090)	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|amod|END_ENTITY	Fatty_acids induce amylin expression and secretion by pancreatic beta-cells .
17916272	0	Fatty_acids	0,11	cAMP-response-element-binding-protein-binding_protein	63,116	Fatty acids	cAMP-response-element-binding-protein-binding protein	MESH:D005227	54244(Tax:10116)	Chemical	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	Fatty_acids in component of milk enhance the expression of the cAMP-response-element-binding-protein-binding_protein -LRB- CBP -RRB- / p300 gene in developing rats .
9782155	0	Fatty_acids	0,11	cholecystokinin	22,37	Fatty acids	cholecystokinin	MESH:D005227	885	Chemical	Gene	secretion|amod|START_ENTITY secretion|compound|END_ENTITY	Fatty_acids stimulate cholecystokinin secretion via an acyl chain length-specific , Ca2 + - dependent mechanism in the enteroendocrine cell line STC-1 .
11415460	0	Fatty_acids	0,11	diacylglycerol_kinase_alpha	42,69	Fatty acids	diacylglycerol kinase alpha	MESH:D005227	1606	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|activation activation|compound|END_ENTITY	Fatty_acids inhibit growth-factor-induced diacylglycerol_kinase_alpha activation in vascular smooth-muscle cells .
19820026	0	Fatty_acids	120,131	insulin	4,11	Fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	concentrations|nmod|START_ENTITY associated|nmod|concentrations associated|nsubjpass|effect effect|compound|END_ENTITY	The insulin effect on cerebrocortical theta activity is associated with serum concentrations of saturated nonesterified Fatty_acids .
23094143	0	Fatty_acids	47,58	insulin	62,69	Fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	Effects of metformin on the regulation of free Fatty_acids in insulin resistance : a double-blind , placebo-controlled study .
23551952	0	Fatty_acids	12,23	lipoprotein-associated_phospholipase_A2	58,97	Fatty acids	lipoprotein-associated phospholipase A2	MESH:D005227	7941	Chemical	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	n-3 and n-6 Fatty_acids are independently associated with lipoprotein-associated_phospholipase_A2 in the Multi-Ethnic Study of Atherosclerosis .
25156249	0	Fatty_acids	23,34	pancreatic_polypeptide	89,111	Fatty acids	pancreatic polypeptide	MESH:D005227	5539	Chemical	Gene	Position|nmod|START_ENTITY affect|nsubj|Position affect|dobj|pattern pattern|nmod|analogues analogues|compound|END_ENTITY	Position and length of Fatty_acids strongly affect receptor selectivity pattern of human pancreatic_polypeptide analogues .
23606724	0	Fatty_acids	0,11	perilipin5	21,31	Fatty acids	perilipin5	MESH:D005227	66968(Tax:10090)	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	Fatty_acids regulate perilipin5 in muscle by activating PPAR .
12824279	0	Fatty_acids	0,11	transforming_growth_factor-beta	21,52	Fatty acids	transforming growth factor-beta	MESH:D005227	7040	Chemical	Gene	modulate|nsubj|START_ENTITY modulate|dobj|activity activity|amod|END_ENTITY	Fatty_acids modulate transforming_growth_factor-beta activity and plasma clearance .
14739285	0	Fatty_acids	0,11	tyrosinase	65,75	Fatty acids	tyrosinase	MESH:D005227	7299	Chemical	Gene	pigmentation|amod|START_ENTITY pigmentation|nmod|degradation degradation|nmod|END_ENTITY	Fatty_acids regulate pigmentation via proteasomal degradation of tyrosinase : a new aspect of ubiquitin-proteasome function .
17478558	0	Fatty_acids	104,115	uncoupling_protein_3	60,80	Fatty acids	uncoupling protein 3	MESH:D005227	25708(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY Differential|dep|role Differential|dep|regulation regulation|nmod|transcription transcription|amod|END_ENTITY	Differential 3,5,3 ' - triiodothyronine-mediated regulation of uncoupling_protein_3 transcription : role of Fatty_acids .
3708859	0	Fatty_acyl	0,10	HDL2	53,57	Fatty acyl	HDL2	null	57338	Chemical	Gene	composition|amod|START_ENTITY composition|nmod|END_ENTITY	Fatty_acyl composition of the major lipid classes of HDL2 and HDL3 of human serum .
1064857	0	FdUMP	27,32	thymidylate_synthetase	49,71	FdUMP	thymidylate synthetase	MESH:D005468	7298	Chemical	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Amino_acid sequence at the FdUMP binding site of thymidylate_synthetase .
22580691	0	Fe	23,25	hub	16,19	Fe	hub	null	1993	Chemical	Gene	signaling|compound|START_ENTITY END_ENTITY|nmod|signaling	Looking for the hub in Fe signaling .
17506526	0	Fe-S	87,91	IscU	81,85	Fe-S	IscU	null	23479	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	In vitro activation of apo-aconitase using a -LSB- 4Fe-4S -RSB- cluster-loaded form of the IscU -LSB- Fe-S -RSB- cluster scaffolding protein .
1935949	0	Fe-S	70,74	NADH-coenzyme_Q_reductase	86,111	Fe-S	NADH-coenzyme Q reductase	null	374291	Chemical	Gene	protein|compound|START_ENTITY protein|nmod|END_ENTITY	Determination of the cDNA sequence for the human mitochondrial 75-kDa Fe-S protein of NADH-coenzyme_Q_reductase .
21776984	0	Fe-S	122,126	frataxin	83,91	Fe-S	frataxin	null	2395	Chemical	Gene	complex|compound|START_ENTITY END_ENTITY|nmod|complex	Structure-function analysis of Friedreich 's _ ataxia mutants reveals determinants of frataxin binding and activation of the Fe-S assembly complex .
8349646	0	Fe-S	23,27	iron-responsive_element-binding_protein	67,106	Fe-S	iron-responsive element-binding protein	null	48	Chemical	Gene	residue|compound|START_ENTITY residue|nmod|END_ENTITY	Modification of a free Fe-S cluster cysteine residue in the active iron-responsive_element-binding_protein prevents RNA binding .
10771495	0	Fedotozine	0,10	Fos	69,72	Fedotozine	Fos	MESH:C067749	314322(Tax:10116)	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|dobj|expression expression|compound|END_ENTITY	Fedotozine , a kappa-opioid agonist , prevents spinal and supra-spinal Fos expression induced by a noxious visceral stimulus in the rat .
22959895	0	Feglymycin	0,10	gp120	118,123	Feglymycin	gp120	null	155971(Tax:11676)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	Feglymycin , a unique natural bacterial antibiotic peptide , inhibits HIV entry by targeting the viral envelope protein gp120 .
9918753	0	Fenfluramine	0,12	endothelin-1	60,72	Fenfluramine	endothelin-1	MESH:D005277	403424(Tax:9615)	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|nmod|END_ENTITY	Fenfluramine potentiates canine pulmonary vasoreactivity to endothelin-1 .
1603884	0	Fenfluramine	0,12	prolactin	28,37	Fenfluramine	prolactin	MESH:D005277	5617	Chemical	Gene	stimulation|amod|START_ENTITY stimulation|nmod|END_ENTITY	Fenfluramine stimulation of prolactin in obsessive-compulsive_disorder .
16873727	0	Fenofibrate	0,11	ApoE	37,41	Fenofibrate	ApoE	MESH:D011345	11816(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|iobj|atherogenesis atherogenesis|nmod|END_ENTITY	Fenofibrate reduces atherogenesis in ApoE * 3Leiden mice : evidence for multiple antiatherogenic effects besides lowering plasma cholesterol .
23236325	0	Fenofibrate	0,11	C-reactive_protein	20,38	Fenofibrate	C-reactive protein	MESH:D011345	1401	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|levels levels|amod|END_ENTITY	Fenofibrate reduces C-reactive_protein levels in hypertriglyceridemic patients with high risks for cardiovascular_diseases .
24523730	0	Fenofibrate	65,76	HMGB1	0,5	Fenofibrate	HMGB1	MESH:D011345	15289(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Involved|nmod|Effect Involved|nsubjpass|END_ENTITY	HMGB1 Is Involved in the Protective Effect of the PPAR_a Agonist Fenofibrate against Cardiac_Hypertrophy .
26693220	0	Fenofibrate	15,26	Irisin	43,49	Fenofibrate	Irisin	MESH:D011345	252995	Chemical	Gene	Levels|compound|START_ENTITY Levels|compound|END_ENTITY	PPAR-a Agonist Fenofibrate Decreased Serum Irisin Levels in Type 2 Diabetes Patients with Hypertriglyceridemia .
26282199	0	Fenofibrate	0,11	Nrf2	22,26	Fenofibrate	Nrf2	MESH:D011345	4780	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Fenofibrate activates Nrf2 through p62-dependent Keap1 degradation .
26282199	0	Fenofibrate	0,11	Nrf2	22,26	Fenofibrate	Nrf2	MESH:D011345	4780	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Fenofibrate activates Nrf2 through p62-dependent Keap1 degradation .
12611907	0	Fenofibrate	0,11	PAF-AH	35,41	Fenofibrate	PAF-AH	MESH:D011345	5048	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Fenofibrate induces HDL-associated PAF-AH but attenuates enzyme activity associated with apoB-containing lipoproteins .
22190909	0	Fenofibrate	15,26	PPAR-a	0,6	Fenofibrate	PPAR-a	MESH:D011345	5465	Chemical	Gene	Level|compound|START_ENTITY Level|compound|END_ENTITY	PPAR-a Agonist Fenofibrate Upregulates Tetrahydrobiopterin Level through Increasing the Expression of Guanosine_5 ' - Triphosphate Cyclohydrolase-I in Human Umbilical Vein Endothelial Cells .
26693220	0	Fenofibrate	15,26	PPAR-a	0,6	Fenofibrate	PPAR-a	MESH:D011345	5465	Chemical	Gene	Levels|compound|START_ENTITY Levels|compound|END_ENTITY	PPAR-a Agonist Fenofibrate Decreased Serum Irisin Levels in Type 2 Diabetes Patients with Hypertriglyceridemia .
26944934	0	Fenofibrate	15,26	PPAR-a	0,6	Fenofibrate	PPAR-a	MESH:D011345	5465	Chemical	Gene	Levels|compound|START_ENTITY Levels|compound|END_ENTITY	PPAR-a Agonist Fenofibrate Decreased RANTES Levels in Type 2 Diabetes Patients with Hypertriglyceridemia .
21270762	0	Fenofibrate	0,11	PPARa	15,20	Fenofibrate	PPARa	MESH:D011345	19013(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Fenofibrate , a PPARa agonist , has renoprotective effects in mice by enhancing renal lipolysis .
25241646	0	Fenofibrate	14,25	PPARa	0,5	Fenofibrate	PPARa	MESH:D011345	25747(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Agonist Agonist|compound|END_ENTITY	PPARa Agonist Fenofibrate Ameliorates Learning and Memory_Deficits in Rats Following Global Cerebral_Ischemia .
26617775	0	Fenofibrate	0,11	PPARa	15,20	Fenofibrate	PPARa	MESH:D011345	5465	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Fenofibrate , a PPARa agonist , protect proximal tubular cells from albumin-bound fatty_acids induced apoptosis via the activation of NF-kB .
12576508	0	Fenofibrate	0,11	PPARalpha	26,35	Fenofibrate	PPARalpha	MESH:D011345	19013(Tax:10090)	Chemical	Gene	START_ENTITY|appos|ligand ligand|nmod|END_ENTITY	Fenofibrate , a ligand for PPARalpha , inhibits aromatase cytochrome P450 expression in the ovary of mouse .
19322024	0	Fenofibrate	0,11	PPARalpha	88,97	Fenofibrate	PPARalpha	MESH:D011345	19013(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|hypertrophy hypertrophy|acl|activating activating|dobj|END_ENTITY	Fenofibrate inhibits adipocyte hypertrophy and insulin resistance by activating adipose PPARalpha in high fat diet-induced obese mice .
25576856	0	Fenofibrate	0,11	PPARalpha	13,22	Fenofibrate	PPARalpha	MESH:D011345	19013(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Fenofibrate -LRB- PPARalpha agonist -RRB- induces beige cell formation in subcutaneous white adipose tissue from diet-induced male obese mice .
26944934	0	Fenofibrate	15,26	RANTES	37,43	Fenofibrate	RANTES	MESH:D011345	6352	Chemical	Gene	Levels|compound|START_ENTITY Levels|compound|END_ENTITY	PPAR-a Agonist Fenofibrate Decreased RANTES Levels in Type 2 Diabetes Patients with Hypertriglyceridemia .
26622498	0	Fenofibrate	0,11	VEGFC	39,44	Fenofibrate	VEGFC	MESH:D011345	7424	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Fenofibrate inhibits the expression of VEGFC and VEGFR-3 in retinal pigmental epithelial cells exposed to hypoxia .
17457016	0	Fenofibrate	0,11	adiponectin	44,55	Fenofibrate	adiponectin	MESH:D011345	9370	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Fenofibrate increases high molecular weight adiponectin in subjects with hypertriglyceridemia .
19023279	5	Fenofibrate	1672,1683	adiponectin	1704,1715	Fenofibrate	adiponectin	MESH:D011345	9370	Chemical	Gene	raised|nsubj|START_ENTITY raised|dobj|levels levels|compound|END_ENTITY	Fenofibrate -LRB- 160 mg/day -RRB- raised adiponectin levels in patients with hypertriglyceridemia and the metabolic_syndrome .
23329136	0	Fenofibrate	0,11	endothelin-1	21,33	Fenofibrate	endothelin-1	MESH:D011345	1906	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Fenofibrate inhibits endothelin-1 expression by peroxisome proliferator-activated receptor a-dependent and independent mechanisms in human endothelial cells .
10460070	0	Fenofibrate	0,11	fibrinogen	29,39	Fenofibrate	fibrinogen	MESH:D011345	2244	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|END_ENTITY	Fenofibrate decreases plasma fibrinogen , improves lipid profile , and reduces uricemia .
24331137	0	Fenofibrate	0,11	insulin	24,31	Fenofibrate	insulin	MESH:D011345	3630	Chemical	Gene	ameliorates|nsubj|START_ENTITY ameliorates|dobj|markers markers|compound|END_ENTITY	Fenofibrate ameliorates insulin resistance , hypertension and novel oxidative stress markers in patients with metabolic_syndrome .
26343046	0	Fenofibrate	21,32	p53	135,138	Fenofibrate	p53	MESH:D011345	22060(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|END_ENTITY	Protective effect of Fenofibrate in renal_ischemia reperfusion injury : Involved in suppressing kinase 2 -LRB- JAK2 -RRB- / transcription 3 -LRB- STAT3 -RRB- / p53 signaling activation .
19054409	0	Fenofibrate	0,11	peroxisome_proliferator-activated_receptor-alpha	15,63	Fenofibrate	peroxisome proliferator-activated receptor-alpha	MESH:D011345	25747(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Fenofibrate , a peroxisome_proliferator-activated_receptor-alpha agonist , exerts anticonvulsive properties .
24211584	0	Fenofibrate	0,11	peroxisome_proliferator-activated_receptor_a	15,59	Fenofibrate	peroxisome proliferator-activated receptor a	MESH:D011345	19013(Tax:10090)	Chemical	Gene	START_ENTITY|appos|ligand ligand|amod|END_ENTITY	Fenofibrate , a peroxisome_proliferator-activated_receptor_a ligand , prevents abnormal_liver_function induced by a fasting-refeeding process .
12236317	0	Fenofibrate	0,11	peroxisome_proliferator-activated_receptor_alpha	15,63	Fenofibrate	peroxisome proliferator-activated receptor alpha	MESH:D011345	25747(Tax:10116)	Chemical	Gene	START_ENTITY|appos|activator activator|amod|END_ENTITY	Fenofibrate , a peroxisome_proliferator-activated_receptor_alpha activator , suppresses experimental autoimmune myocarditis by stimulating the interleukin-10 pathway in rats .
16087294	0	Fenofibrate	0,11	peroxisome_proliferator-activated_receptor_alpha	15,63	Fenofibrate	peroxisome proliferator-activated receptor alpha	MESH:D011345	25747(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Fenofibrate , a peroxisome_proliferator-activated_receptor_alpha agonist , exerts neuroprotective effects in traumatic_brain_injury .
20204774	0	Fenofibrate	0,11	peroxisome_proliferator-activated_receptor_alpha	15,63	Fenofibrate	peroxisome proliferator-activated receptor alpha	MESH:D011345	19013(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Fenofibrate , a peroxisome_proliferator-activated_receptor_alpha agonist , improves hepatic microcirculatory patency and oxygen availability in a high-fat-diet-induced fatty_liver in mice .
19088257	0	Fenofibrate	0,11	retinol-binding_protein-4	26,51	Fenofibrate	retinol-binding protein-4	MESH:D011345	5950	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|xcomp|END_ENTITY	Fenofibrate reduces serum retinol-binding_protein-4 by suppressing its expression in adipose tissue .
23918212	0	Fenofibrate	0,11	vaspin	28,34	Fenofibrate	vaspin	MESH:D011345	145264	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Fenofibrate increases serum vaspin by upregulating its expression in adipose tissue .
8297388	0	Fenofibric_acid	0,15	apolipoprotein_A-IV	36,55	Fenofibric acid	apolipoprotein A-IV	MESH:C006012	337	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	Fenofibric_acid modulates the human apolipoprotein_A-IV gene expression in HepG2 cells .
2831108	0	Fenoterol	0,9	a_beta	69,75	Fenoterol	a beta	MESH:D005280	351	Chemical	Gene	stimulation|amod|START_ENTITY stimulation|dep|END_ENTITY	Fenoterol stimulation of sodium transport in the isolated toad skin : a_beta adrenergic effect .
10583037	0	Fenoterol	0,9	erythropoietin	27,41	Fenoterol	erythropoietin	MESH:D005280	2056	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|compound|END_ENTITY	Fenoterol stimulates human erythropoietin production via activation of the renin angiotensin system .
9209250	0	Fenoterol	0,9	erythropoietin	39,53	Fenoterol	erythropoietin	MESH:D005280	2056	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|production production|compound|END_ENTITY	Fenoterol but not dobutamine increases erythropoietin production in humans .
24357007	0	Fenretinide	0,11	stearoyl-CoA_desaturase	67,90	Fenretinide	stearoyl-CoA desaturase	MESH:D017313	6319	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|degradation degradation|nmod|END_ENTITY	Fenretinide induces ubiquitin-dependent proteasomal degradation of stearoyl-CoA_desaturase in human retinal pigment epithelial cells .
8072000	0	Fentanyl	0,8	atrial_natriuretic_peptide	20,46	Fentanyl	atrial natriuretic peptide	MESH:D005283	24602(Tax:10116)	Chemical	Gene	stimulates|amod|START_ENTITY END_ENTITY|nsubj|stimulates	Fentanyl stimulates atrial_natriuretic_peptide secretion .
16946257	0	Fermentation_acids	0,18	MD1	76,79	Fermentation acids	MD1	null	4095	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|nmod|END_ENTITY	Fermentation_acids inhibit amino_acid deamination by Clostridium sporogenes MD1 via a mechanism involving a decline in intracellular glutamate rather than protonmotive force .
16664015	0	Ferredoxin	10,20	Diaphorase	28,38	Ferredoxin	Diaphorase	CHEBI:5017	1738	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|Activity Activity|compound|END_ENTITY	Effect of Ferredoxin on the Diaphorase Activity of Cyanobacterial Ferredoxin-NADP_Reductase .
16664015	0	Ferredoxin	10,20	Ferredoxin-NADP_Reductase	66,91	Ferredoxin	Ferredoxin-NADP Reductase	CHEBI:5017	2232	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of Ferredoxin on the Diaphorase Activity of Cyanobacterial Ferredoxin-NADP_Reductase .
25956617	0	Ferulic_acid	0,12	GLUT2	31,36	Ferulic acid	GLUT2	MESH:C004999	25351(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Ferulic_acid regulates hepatic GLUT2 gene expression in high fat and fructose-induced type-2 diabetic adult male rat .
25677620	0	Ferulic_acid	0,12	PARP	33,37	Ferulic acid	PARP	MESH:C004999	11545(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|compound|END_ENTITY	Ferulic_acid in combination with PARP inhibitor sensitizes breast_cancer cells as chemotherapeutic strategy .
21782921	0	Ferulic_acid	0,12	cyclin_D1	76,85	Ferulic acid	cyclin D1	MESH:C004999	595	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Ferulic_acid promotes endothelial cells proliferation through up-regulating cyclin_D1 and VEGF .
21043551	0	Ferulic_acid	0,12	extracellular_regulated_kinase	86,116	Ferulic acid	extracellular regulated kinase	MESH:C004999	5594	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|END_ENTITY	Ferulic_acid protects lymphocytes from radiation-predisposed oxidative stress through extracellular_regulated_kinase .
22466441	0	Ferulic_acid	0,12	heme_oxygenase-1	21,37	Ferulic acid	heme oxygenase-1	MESH:C004999	3162	Chemical	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Ferulic_acid induces heme_oxygenase-1 via activation of ERK and Nrf2 .
24582902	0	Ferulic_acid	0,12	peroxiredoxin-2	73,88	Ferulic acid	peroxiredoxin-2	MESH:C004999	29338(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|decrease decrease|nmod|expression expression|amod|END_ENTITY	Ferulic_acid attenuates the cerebral ischemic injury-induced decrease in peroxiredoxin-2 and thioredoxin expression .
25953731	0	Fexofenadine	10,22	P-Glycoprotein	111,125	Fexofenadine	P-Glycoprotein	MESH:C093230	5243	Chemical	Gene	Prodrugs|compound|START_ENTITY Design|nmod|Prodrugs Based|nsubj|Design Based|nmod|END_ENTITY	Design of Fexofenadine Prodrugs Based on Tissue-Specific Esterase Activity and Their Dissimilar Recognition by P-Glycoprotein .
15125696	0	Fexofenadine	0,12	P-glycoprotein	76,90	Fexofenadine	P-glycoprotein	MESH:C093230	5243	Chemical	Gene	affect|nsubj|START_ENTITY affect|parataxis|substrates substrates|amod|END_ENTITY	Fexofenadine does not affect omeprazole pharmacokinetics : both are putative P-glycoprotein substrates .
19114463	0	Fexofenadine	0,12	P-glycoprotein	69,83	Fexofenadine	P-glycoprotein	MESH:C093230	67078(Tax:10090)	Chemical	Gene	exposure|amod|START_ENTITY END_ENTITY|nsubj|exposure	Fexofenadine brain exposure and the influence of blood-brain barrier P-glycoprotein after fexofenadine and terfenadine administration .
26282541	0	Fibrin	0,6	GPVI	17,21	Fibrin	GPVI	null	51206	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Fibrin activates GPVI in human and mouse platelets .
26282541	0	Fibrin	0,6	GPVI	17,21	Fibrin	GPVI	null	51206	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Fibrin activates GPVI in human and mouse platelets .
11287277	0	Fibrin	0,6	IL-8	15,19	Fibrin	IL-8	null	3576	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Fibrin induces IL-8 expression from human oral_squamous_cell_carcinoma cells .
2976994	0	Fibrin	0,6	tissue-type_plasminogen_activator	95,128	Fibrin	tissue-type plasminogen activator	null	5327	Chemical	Gene	metabolism|nsubj|START_ENTITY metabolism|nmod|END_ENTITY	Fibrin metabolism in patients with acute_myocardial_infarction during and after treatment with tissue-type_plasminogen_activator .
9175247	0	Fibrinopeptide_A	0,16	fibrinogen	44,54	Fibrinopeptide A	fibrinogen	MESH:D005344	2244	Chemical	Gene	release|compound|START_ENTITY release|nmod|END_ENTITY	Fibrinopeptide_A release from intraplatelet fibrinogen is related to thrombin platelet activation .
16243292	0	Fibrocystin	0,11	CAML	27,31	Fibrocystin	CAML	null	819	Chemical	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Fibrocystin interacts with CAML , a protein involved in Ca2 + signaling .
11698153	0	Fibronectin	0,11	A_beta	26,32	Fibronectin	A beta	null	54226(Tax:10116)	Chemical	Gene	modulation|compound|START_ENTITY modulation|nmod|END_ENTITY	Fibronectin modulation by A_beta amyloid peptide -LRB- 25-35 -RRB- in cultured astrocytes of newborn rat cortex .
23261429	0	Fibronectin	0,11	MMP2	20,24	Fibronectin	MMP2	null	4313	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nummod|END_ENTITY	Fibronectin induces MMP2 expression in human prostate_cancer cells .
25208219	0	Fibronectin	0,11	MMP2	30,34	Fibronectin	MMP2	null	4313	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|expression expression|compound|END_ENTITY	Fibronectin affects transient MMP2 gene expression through DNA demethylation changes in non-invasive breast_cancer cell lines .
2023218	0	Fibronectin	0,11	TGF-beta	87,95	Fibronectin	TGF-beta	null	7040	Chemical	Gene	release|nsubj|START_ENTITY release|nmod|END_ENTITY	Fibronectin release by systemic_sclerosis and normal dermal fibroblasts in response to TGF-beta .
11339502	0	Fibronectin	0,11	TGF-beta1	55,64	Fibronectin	TGF-beta1	null	7040	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Fibronectin regulates the activation of THP-1 cells by TGF-beta1 .
25657110	0	Fibronectin	0,11	mTOR	61,65	Fibronectin	mTOR	null	21977(Tax:10090)	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Fibronectin promotes cell proliferation and invasion through mTOR signaling pathway activation in gallbladder_cancer .
20156194	0	Filamin_associates	0,18	MKK7	50,54	Filamin associates	MKK7	null	5609	Chemical	Gene	kinases|nsubj|START_ENTITY kinases|dobj|END_ENTITY	Filamin_associates with stress signalling kinases MKK7 and MKK4 and regulates JNK activation .
26482170	0	Filgotinib	94,104	JAK1	129,133	Filgotinib	JAK1	null	3716	Chemical	Gene	Pharmacokinetics|nmod|START_ENTITY Pharmacokinetics|appos|Inhibitor Inhibitor|compound|END_ENTITY	Author 's Reply to Srinivas : `` Pharmacokinetics and Pharmacokinetic/Pharmacodynamic Modeling of Filgotinib -LRB- GLPG0634 -RRB- , a Selective JAK1 Inhibitor , in Support of Phase IIB Dose Selection '' .
26640409	0	Fimasartan	0,10	Nrf2	166,170	Fimasartan	Nrf2	MESH:C558933	18024(Tax:10090)	Chemical	Gene	START_ENTITY|dep|Role Role|nmod|END_ENTITY	Fimasartan , a Novel Angiotensin-Receptor Blocker , Protects against Renal_Inflammation and Fibrosis in Mice with Unilateral Ureteral Obstruction : the Possible Role of Nrf2 .
1371291	0	Finasteride	0,11	5_alpha-reductase	29,46	Finasteride	5 alpha-reductase	MESH:D018120	6715	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Finasteride , an inhibitor of 5_alpha-reductase , suppresses prostatic dihydrotestosterone in men with benign_prostatic_hyperplasia .
7679063	0	Finasteride	0,11	5_alpha-reductase	15,32	Finasteride	5 alpha-reductase	MESH:D018120	6715	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Finasteride : a 5_alpha-reductase inhibitor .
7689728	0	Finasteride	0,11	5_alpha-reductase	23,40	Finasteride	5 alpha-reductase	MESH:D018120	6715	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Finasteride : the first 5_alpha-reductase inhibitor .
8389191	0	Finasteride	0,11	5_alpha-reductase	28,45	Finasteride	5 alpha-reductase	MESH:D018120	6715	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Finasteride : a slow-binding 5_alpha-reductase inhibitor .
8537164	0	Finasteride	0,11	5_alpha-reductase	21,38	Finasteride	5 alpha-reductase	MESH:D018120	6715	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Finasteride inhibits 5_alpha-reductase activity in human dermal fibroblasts : prediction of its therapeutic application in androgen-related skin_diseases .
9827060	0	Finasteride	9,20	5_alpha-reductase	31,48	Finasteride	5 alpha-reductase	MESH:D018120	6715	Chemical	Gene	Proscar|appos|START_ENTITY inhibits|nsubj|Proscar inhibits|dobj|activity activity|amod|END_ENTITY	Proscar -LRB- Finasteride -RRB- inhibits 5_alpha-reductase activity in the ovaries and testes of Lytechinus variegatus Lamarck -LRB- Echinodermata : Echinoidea -RRB- .
15992088	0	Finasteride	0,11	5alpha-reductase	22,38	Finasteride	5alpha-reductase	MESH:D018120	6715	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Finasteride , a Type 2 5alpha-reductase inhibitor , in the treatment of men with androgenetic_alopecia .
25765414	0	Finasteride	4,15	Androgen_Receptor	49,66	Finasteride	Androgen Receptor	MESH:D018120	367	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Re : Finasteride Treatment Alters Tissue Specific Androgen_Receptor Expression in Prostate Tissues .
24250563	0	Finasteride	52,63	BCL-2	0,5	Finasteride	BCL-2	MESH:D018120	24224(Tax:10116)	Chemical	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	BCL-2 and Bax Expression in Skin Flaps Treated with Finasteride or Azelaic_Acid .
18360719	0	Finasteride	0,11	Bcl-2	34,39	Finasteride	Bcl-2	MESH:D018120	596	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|apoptosis apoptosis|nmod|proteins proteins|amod|END_ENTITY	Finasteride induces apoptosis via Bcl-2 , Bcl-xL , Bax and caspase-3 proteins in LNCaP human prostate_cancer cell line .
9426721	10	Finasteride	1905,1916	PSA	1949,1952	Finasteride	PSA	MESH:D018120	354	Chemical	Gene	appears|nsubj|START_ENTITY appears|xcomp|lower lower|dobj|levels levels|compound|END_ENTITY	CONCLUSIONS : Finasteride appears to lower total and free PSA levels equally in men with BPH and does not appear to change the ratio of free to total serum PSA .
21557276	0	Finasteride	0,11	androgen_receptor	38,55	Finasteride	androgen receptor	MESH:D018120	367	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Finasteride upregulates expression of androgen_receptor in hyperplastic prostate and LNCaP cells : implications for chemoprevention of prostate_cancer .
24789081	0	Finasteride	0,11	androgen_receptor	45,62	Finasteride	androgen receptor	MESH:D018120	367	Chemical	Gene	alters|amod|START_ENTITY tissue|nsubj|alters tissue|dobj|expression expression|compound|END_ENTITY	Finasteride treatment alters tissue specific androgen_receptor expression in prostate tissues .
22891354	0	Fingolimod	0,10	BDNF	68,72	Fingolimod	BDNF	MESH:C098720	12064(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|amod|END_ENTITY	Fingolimod , a sphingosine-1 phosphate receptor modulator , increases BDNF levels and improves symptoms of a mouse model of Rett_syndrome .
26224441	0	Firocoxib	22,31	Cyclooxygenase_2	58,74	Firocoxib	Cyclooxygenase 2	MESH:C487384	19225(Tax:10090)	Chemical	Gene	Efficacy|nmod|START_ENTITY Efficacy|appos|Inhibitor Inhibitor|nmod|END_ENTITY	Analgesic Efficacy of Firocoxib , a Selective Inhibitor of Cyclooxygenase_2 , in a Mouse Model of Incisional Pain .
7684734	0	Fiscalins	0,9	substance_P	15,26	Fiscalins	substance P	null	6863	Chemical	Gene	START_ENTITY|dep|inhibitors inhibitors|compound|END_ENTITY	Fiscalins : new substance_P inhibitors produced by the fungus Neosartorya_fischeri .
18662803	0	Fisetin	0,7	CD36	39,43	Fisetin	CD36	MESH:C017875	948	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Fisetin , morin and myricetin attenuate CD36 expression and oxLDL uptake in U937-derived macrophages .
21520244	0	Fisetin	0,7	HO-1	30,34	Fisetin	HO-1	MESH:C017875	3162	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Fisetin induces Nrf2-mediated HO-1 expression through PKC - ___ and_p38 in human umbilical vein endothelial cells .
25286082	0	Fisetin	0,7	SIRT1	151,156	Fisetin	SIRT1	MESH:C017875	93759(Tax:10090)	Chemical	Gene	up-regulates|nsubj|START_ENTITY up-regulates|nmod|adipocytes adipocytes|nmod|activation activation|nmod|silent_mating_type_information_regulation_2_homologue_1 silent_mating_type_information_regulation_2_homologue_1|appos|END_ENTITY	Fisetin up-regulates the expression of adiponectin in 3T3-L1 adipocytes via the activation of silent_mating_type_information_regulation_2_homologue_1 -LRB- SIRT1 -RRB- - deacetylase and peroxisome_proliferator-activated_receptors -LRB- PPARs -RRB- .
26499075	0	Fisetin	0,7	Sirt1	16,21	Fisetin	Sirt1	MESH:C017875	93759(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Fisetin induces Sirt1 expression while inhibiting early adipogenesis in 3T3-L1 cells .
17387141	0	Fisetin	0,7	cyclin-dependent_kinase_6	25,50	Fisetin	cyclin-dependent kinase 6	MESH:C017875	1021	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Fisetin , an inhibitor of cyclin-dependent_kinase_6 , down-regulates nuclear factor-kappaB-regulated cell proliferation , antiapoptotic and metastatic gene products through the suppression of TAK-1_and_receptor-interacting_protein-regulated_IkappaBalpha kinase activation .
23818290	0	Fisetin	0,7	miR-378	63,70	Fisetin	miR-378	MESH:C017875	723889(Tax:10090)	Chemical	Gene	protects|nsubj|START_ENTITY protects|advcl|inhibiting inhibiting|xcomp|END_ENTITY	Fisetin protects against hepatosteatosis in mice by inhibiting miR-378 .
21054790	0	Fisetin	0,7	p53	92,95	Fisetin	p53	MESH:C017875	7157	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Fisetin , a dietary flavonoid , induces cell cycle arrest and apoptosis through activation of p53 and inhibition of NF-kappa_B pathways in bladder_cancer cells .
18263703	0	Flagellin	0,9	S100A7c	64,71	Flagellin	S100A7c	null	6278	Chemical	Gene	inducer|nsubj|START_ENTITY inducer|nmod|END_ENTITY	Flagellin is the principal inducer of the antimicrobial peptide S100A7c -LRB- psoriasin -RRB- in human epidermal keratinocytes exposed to Escherichia_coli .
15324458	0	Flagellin	0,9	TLR5	21,25	Flagellin	TLR5	null	7100	Chemical	Gene	START_ENTITY|acl|acting acting|nmod|END_ENTITY	Flagellin acting via TLR5 is the major activator of key signaling pathways leading to NF-kappa_B and proinflammatory gene program activation in intestinal epithelial cells .
22013117	0	Flagellin	0,9	TLR5	13,17	Flagellin	TLR5	null	7100	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Flagellin , a TLR5 agonist , reduces graft-versus-host disease in allogeneic hematopoietic stem cell transplantation recipients while enhancing antiviral immunity .
24442437	0	Flagellin	0,9	TLR5	47,51	Flagellin	TLR5	null	53791(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|pathway pathway|amod|END_ENTITY	Flagellin induces antibody responses through a TLR5 - and inflammasome-independent pathway .
27025921	0	Flavanoids	0,10	NEDD-4	24,30	Flavanoids	NEDD-4	null	4734	Chemical	Gene	START_ENTITY|nmod|Inhibitors Inhibitors|compound|END_ENTITY	Flavanoids as Potential NEDD-4 Inhibitors : In Silico Discovery Using Molecular Docking and ADME Studies .
25735399	0	Flavanones	14,24	TNF-a	123,128	Flavanones	TNF-a	MESH:D044950	7124	Chemical	Gene	START_ENTITY|nmod|Production Production|amod|END_ENTITY	C-Geranylated Flavanones from Paulownia tomentosa Fruits as Potential Anti-inflammatory Compounds Acting via Inhibition of TNF-a Production .
2404494	0	Flavin	0,6	glutathione_reductase	45,66	Flavin	glutathione reductase	MESH:C024132	2936	Chemical	Gene	analogs|nsubj|START_ENTITY analogs|nmod|inhibitors inhibitors|amod|END_ENTITY	Flavin analogs with antimalarial activity as glutathione_reductase inhibitors .
21971443	0	Flavin_adenine_dinucleotide	0,27	quinone_reductase_2	39,58	Flavin adenine dinucleotide	quinone reductase 2	MESH:D005182	4835	Chemical	Gene	content|amod|START_ENTITY content|nmod|END_ENTITY	Flavin_adenine_dinucleotide content of quinone_reductase_2 : analysis and optimization for structure-function studies .
21765617	0	Flavocoxid	0,10	COX-2	117,122	Flavocoxid	COX-2	MESH:C544478	26198(Tax:10116)	Chemical	Gene	A2|compound|START_ENTITY modifies|nsubj|A2 modifies|dobj|expression expression|compound|END_ENTITY	Flavocoxid inhibits phospholipase A2 , peroxidase moieties of the cyclooxygenases -LRB- COX -RRB- , and 5-lipoxygenase , modifies COX-2 gene expression , and acts as an antioxidant .
22356547	0	Flavocoxid	0,10	COX-2	32,37	Flavocoxid	COX-2	MESH:C544478	17709(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Flavocoxid , a dual inhibitor of COX-2 and 5-LOX of natural origin , attenuates the inflammatory response and protects mice from sepsis .
19681869	0	Flavocoxid	0,10	cyclooxygenase_and_5-lipoxygenase	32,65	Flavocoxid	cyclooxygenase and 5-lipoxygenase	MESH:C544478	25290(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Flavocoxid , a dual inhibitor of cyclooxygenase_and_5-lipoxygenase , blunts pro-inflammatory phenotype activation in endotoxin-stimulated macrophages .
17643414	0	Flavone	0,7	PARP-1	11,17	Flavone	PARP-1	MESH:C043562	142	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|compound|END_ENTITY	Flavone as PARP-1 inhibitor : its effect on lipopolysaccharide induced gene-expression .
26302339	0	Flavone	4,11	SREBP-2	32,39	Flavone	SREBP-2	MESH:C043562	6721	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	The Flavone Luteolin Suppresses SREBP-2 Expression and Post-Translational Activation in Hepatic Cells .
25680459	0	Flavone	0,7	nitric_oxide_synthase	17,38	Flavone	nitric oxide synthase	MESH:C043562	4843	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Flavone inhibits nitric_oxide_synthase -LRB- NOS -RRB- activity , nitric_oxide production and protein S-nitrosylation in breast_cancer cells .
11834736	0	Flavonoid	0,9	sodium-dependent_vitamin_C_transporter_1	24,64	Flavonoid	sodium-dependent vitamin C transporter 1	CHEBI:47916	50621(Tax:10116)	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Flavonoid inhibition of sodium-dependent_vitamin_C_transporter_1 -LRB- SVCT1 -RRB- and glucose_transporter_isoform_2 -LRB- GLUT2 -RRB- , intestinal transporters for vitamin_C and Glucose .
22842046	0	Flavonoid	0,9	transthyretin	34,47	Flavonoid	transthyretin	CHEBI:47916	7276	Chemical	Gene	interactions|amod|START_ENTITY interactions|nmod|END_ENTITY	Flavonoid interactions with human transthyretin : combined structural and thermodynamic analysis .
24853561	0	Flavonoid	0,9	tyrosinase	32,42	Flavonoid	tyrosinase	CHEBI:47916	7299	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|inhibitors inhibitors|compound|END_ENTITY	Flavonoid derivatives as potent tyrosinase inhibitors - a survey of recent findings between 2008-2013 .
12565887	0	Flavonoid_glycoside	0,19	DNA_polymerase_alpha	51,71	Flavonoid glycoside	DNA polymerase alpha	null	5422	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	Flavonoid_glycoside : a new inhibitor of eukaryotic DNA_polymerase_alpha and a new carrier for inhibitor-affinity chromatography .
12097654	0	Flavonoids	0,10	5-lipoxygenase	46,60	Flavonoids	5-lipoxygenase	MESH:D005419	240	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|END_ENTITY	Flavonoids of cocoa inhibit recombinant human 5-lipoxygenase .
12357401	0	Flavonoids	0,10	COX-1	32,37	Flavonoids	COX-1	MESH:D005419	4512	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Flavonoids and stilbenoids with COX-1 and COX-2 inhibitory activity from Dracaena loureiri .
23188647	0	Flavonoids	0,10	CYP3A4	38,44	Flavonoids	CYP3A4	MESH:D005419	1576	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	Flavonoids and polymer derivatives as CYP3A4 inhibitors for improved oral drug bioavailability .
25873069	0	Flavonoids	100,110	Hypoxia-inducible_Factor-1a	14,41	Flavonoids	Hypoxia-inducible Factor-1a	MESH:D005419	3091	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of Hypoxia-inducible_Factor-1a and Vascular_Endothelial_Growth_Factor Signaling by Plant Flavonoids .
12044887	0	Flavonoids	0,10	ICAM-1	53,59	Flavonoids	ICAM-1	MESH:D005419	3383	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|compound|END_ENTITY	Flavonoids differentially regulate IFN_gamma-induced ICAM-1 expression in human keratinocytes : molecular mechanisms of action .
25187688	0	Flavonoids	43,53	NS1	64,67	Flavonoids	NS1	MESH:D005419	10625	Chemical	Gene	START_ENTITY|nmod|Inhibitors Inhibitors|compound|END_ENTITY	Molecular Docking Based Screening of Plant Flavonoids as Dengue NS1 Inhibitors .
22272764	0	Flavonoids	0,10	Nrf2	61,65	Flavonoids	Nrf2	MESH:D005419	18024(Tax:10090)	Chemical	Gene	protect|nsubj|START_ENTITY protect|nmod|END_ENTITY	Flavonoids protect cerebrovascular endothelial cells through Nrf2 and PI3K from b-amyloid peptide-induced oxidative damage .
25004882	0	Flavonoids	0,10	TNF-a	41,46	Flavonoids	TNF-a	MESH:D005419	24835(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|secretion secretion|amod|END_ENTITY	Flavonoids from Litsea coreana decreases TNF-a secretion from peritoneal macrophages in adjuvant-induced arthritis rats via UPR pathway .
6418162	0	Flavonoids	0,10	arachidonate_5-lipoxygenase	33,60	Flavonoids	arachidonate 5-lipoxygenase	MESH:D005419	404074(Tax:9913)	Chemical	Gene	START_ENTITY|dep|inhibitors inhibitors|nmod|END_ENTITY	Flavonoids : potent inhibitors of arachidonate_5-lipoxygenase .
14644660	0	Flavonoids	0,10	aryl_hydrocarbon_receptor	14,39	Flavonoids	aryl hydrocarbon receptor	MESH:D005419	196	Chemical	Gene	START_ENTITY|nmod|agonists/antagonists agonists/antagonists|compound|END_ENTITY	Flavonoids as aryl_hydrocarbon_receptor agonists/antagonists : effects of structure and cell context .
20649574	0	Flavonoids	0,10	cyclooxygenase_2	48,64	Flavonoids	cyclooxygenase 2	MESH:D005419	29527(Tax:10116)	Chemical	Gene	exert|nsubj|START_ENTITY exert|nmod|END_ENTITY	Flavonoids exert distinct modulatory actions on cyclooxygenase_2 and NF-kappaB in an intestinal epithelial cell line -LRB- IEC18 -RRB- .
21309574	0	Flavonoids	0,10	hypoxia-inducible_factor-1a	136,163	Flavonoids	hypoxia-inducible factor-1a	MESH:D005419	3091	Chemical	Gene	induce|nsubj|START_ENTITY induce|parataxis|mediated mediated|nmod|accumulation accumulation|nmod|END_ENTITY	Flavonoids from Radix Astragali induce the expression of erythropoietin in cultured cells : a signaling mediated via the accumulation of hypoxia-inducible_factor-1a .
24768712	0	Flavonoids	0,10	iNOS	19,23	Flavonoids	iNOS	MESH:D005419	18126(Tax:10090)	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|production production|amod|END_ENTITY	Flavonoids inhibit iNOS production via mitogen activated proteins in lipoteichoic acid stimulated cardiomyoblasts .
9246576	0	Flavonoids	0,10	phospholipase_A2	110,126	Flavonoids	phospholipase A2	MESH:D005419	151056	Chemical	Gene	START_ENTITY|dep|importance importance|nmod|structure structure|nmod|inhibition inhibition|nmod|END_ENTITY	Flavonoids as phospholipase_A2 inhibitors : importance of their structure for selective inhibition of group II phospholipase_A2 .
9246576	0	Flavonoids	0,10	phospholipase_A2	14,30	Flavonoids	phospholipase A2	MESH:D005419	151056	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Flavonoids as phospholipase_A2 inhibitors : importance of their structure for selective inhibition of group II phospholipase_A2 .
20117183	0	Flavonoids	0,10	prolyl_oligopeptidase	16,37	Flavonoids	prolyl oligopeptidase	MESH:D005419	5550	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Flavonoids with prolyl_oligopeptidase inhibitory activity isolated from Scutellaria racemosa Pers .
9287415	0	Flavonoids	0,10	tumor_necrosis_factor-alpha	61,88	Flavonoids	tumor necrosis factor-alpha	MESH:D005419	21926(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|cytotoxicity cytotoxicity|nmod|END_ENTITY	Flavonoids as inhibitors or enhancers of the cytotoxicity of tumor_necrosis_factor-alpha in L-929 tumor cells .
18386491	0	Flavonoids	0,10	type_I_DNA_topoisomerase	56,80	Flavonoids	type I DNA topoisomerase	MESH:D005419	7150	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|END_ENTITY	Flavonoids in Helichrysum pamphylicum inhibit mammalian type_I_DNA_topoisomerase .
16448205	0	Flavonoids	0,10	tyrosinase	23,33	Flavonoids	tyrosinase	MESH:D005419	7299	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Flavonoids as mushroom tyrosinase inhibitors : a fluorescence quenching study .
18729255	0	Flavonoids	0,10	tyrosinase	87,97	Flavonoids	tyrosinase	MESH:D005419	22173(Tax:10090)	Chemical	Gene	attenuate|advmod|START_ENTITY attenuate|advcl|increasing increasing|dobj|levels levels|amod|END_ENTITY	Flavonoids , taxifolin and luteolin attenuate cellular melanogenesis despite increasing tyrosinase protein levels .
18295609	0	Flavonols	0,9	BACE-1	26,32	Flavonols	BACE-1	MESH:D044948	23621	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Flavonols and flavones as BACE-1 inhibitors : structure-activity relationship in cell-free , cell-based and in silico studies reveal novel pharmacophore features .
10552777	0	Flavonols	0,9	tyrosinase	31,41	Flavonols	tyrosinase	MESH:D044948	7299	Chemical	Gene	START_ENTITY|dep|activity activity|amod|END_ENTITY	Flavonols from saffron flower : tyrosinase inhibitory activity and inhibition mechanism .
10976523	0	Flavonols	0,9	tyrosinase	38,48	Flavonols	tyrosinase	MESH:D044948	7299	Chemical	Gene	START_ENTITY|dep|activity activity|amod|END_ENTITY	Flavonols from Heterotheca inuloides : tyrosinase inhibitory activity and structural criteria .
22391209	0	Flavopiridol	0,12	AKT	40,43	Flavopiridol	AKT	MESH:C077990	207	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Flavopiridol induces phosphorylation of AKT in a human glioblastoma cell line , in contrast to siRNA-mediated silencing of Cdk9 : Implications for drug design and development .
21728742	0	Flavopiridol	0,12	BCL-2	21,26	Flavopiridol	BCL-2	MESH:C077990	596	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Flavopiridol induces BCL-2 expression and represses oncogenic transcription factors in leukemic blasts from adults with refractory acute_myeloid_leukemia .
12457721	0	Flavopiridol	0,12	Bcl-x	89,94	Flavopiridol	Bcl-x	MESH:C077990	598	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|regulating regulating|dobj|END_ENTITY	Flavopiridol , a cyclin dependent kinase -LRB- CDK -RRB- inhibitor , induces apoptosis by regulating Bcl-x in oral_cancer cells .
14630924	0	Flavopiridol	0,12	NF-kappaB	22,31	Flavopiridol	NF-kappaB	MESH:C077990	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation : abrogation of cyclin_D1 , cyclooxygenase-2 , and matrix metalloprotease-9 .
12688354	0	Flavopiridol	0,12	p38	87,90	Flavopiridol	p38	MESH:C077990	1432	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Flavopiridol induces apoptosis in B-cell_chronic_lymphocytic_leukaemia cells through a p38 and ERK MAP kinase-dependent mechanism .
11482875	0	Flavopiridol	0,12	p53	128,131	Flavopiridol	p53	MESH:C077990	7157	Chemical	Gene	induces|nsubj|START_ENTITY induces|dep|containing containing|dobj|genes genes|compound|END_ENTITY	Flavopiridol induces apoptosis and caspase-3 activation of a newly characterized Burkitt 's _ lymphoma cell line containing mutant p53 genes .
15150125	0	Flavopiridol	0,12	p53	21,24	Flavopiridol	p53	MESH:C077990	7157	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Flavopiridol induces p53 via initial inhibition of Mdm2 and p21 and , independently of p53 , sensitizes apoptosis-reluctant cells to tumor necrosis factor .
15150125	0	Flavopiridol	0,12	p53	86,89	Flavopiridol	p53	MESH:C077990	7157	Chemical	Gene	induces|nsubj|START_ENTITY induces|dep|END_ENTITY	Flavopiridol induces p53 via initial inhibition of Mdm2 and p21 and , independently of p53 , sensitizes apoptosis-reluctant cells to tumor necrosis factor .
18640498	0	Flavopiridol	0,12	p53	99,102	Flavopiridol	p53	MESH:C077990	7157	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|effects effects|acl:relcl|mutated mutated|nsubjpass|END_ENTITY	Flavopiridol potentiates the cytotoxic effects of radiation in radioresistant tumor cells in which p53 is mutated or Bcl-2 is overexpressed .
9808574	0	Flavopiridol	0,12	p53	162,165	Flavopiridol	p53	MESH:C077990	7157	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|apoptosis apoptosis|nmod|cells cells|nmod|activation activation|nmod|END_ENTITY	Flavopiridol induces apoptosis in chronic_lymphocytic_leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53 .
12115498	0	Flavopiridol	0,12	vascular_endothelial_growth_factor	22,56	Flavopiridol	vascular endothelial growth factor	MESH:C077990	7422	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	Flavopiridol inhibits vascular_endothelial_growth_factor production induced by hypoxia or picolinic_acid in human neuroblastoma .
24599044	0	Flecainide	0,10	SCN5A	119,124	Flecainide	SCN5A	MESH:D005424	6331	Chemical	Gene	provocation|compound|START_ENTITY reveals|nsubj|provocation reveals|nmod|family family|nmod|mutation mutation|nmod|END_ENTITY	Flecainide provocation reveals concealed brugada_syndrome in a long_QT_syndrome family with a novel L1786Q mutation in SCN5A .
26299935	0	Flubendazole	62,74	Atg4B	47,52	Flubendazole	Atg4B	MESH:C018945	23192	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Systems biology-based discovery of a potential Atg4B agonist -LRB- Flubendazole -RRB- that induces autophagy in breast_cancer .
19429397	0	Fluconazole	0,11	CYP26	19,24	Fluconazole	CYP26	MESH:D015725	13082(Tax:10090)	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|expression expression|compound|END_ENTITY	Fluconazole alters CYP26 gene expression in mouse embryos .
20951697	0	Fluconazole	0,11	hERG	21,25	Fluconazole	hERG	MESH:D015725	2078	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Fluconazole inhibits hERG K -LRB- + -RRB- channel by direct block and disruption of protein trafficking .
17961496	0	Fludarabine	0,11	VEGF	57,61	Fludarabine	VEGF	MESH:C024352	7422	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|nmod|END_ENTITY	Fludarabine reduces survivability of HepG2 cells through VEGF under hypoxia .
16030145	1	Fludelone	169,178	Flu	180,183	Fludelone	Flu	MESH:C506241	51364	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|appos|END_ENTITY	26-Trifluoro - -LRB- E -RRB- -9,10 - dehydro-12 ,13 - desoxyepothilone_B -LSB- Fludelone -LRB- Flu -RRB- -RSB- has shown broad antitumor activity in solid_tumor models .
8985717	0	Flumazenil	0,10	CRH	48,51	Flumazenil	CRH	MESH:D005442	1392	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|nmod|END_ENTITY	Flumazenil attenuates the pituitary response to CRH in healthy males .
7814832	0	Flumazenil	0,10	growth_hormone	22,36	Flumazenil	growth hormone	MESH:D005442	2688	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|response response|amod|END_ENTITY	Flumazenil effects on growth_hormone response to gamma-hydroxybutyric_acid .
16485034	0	Flunarizine	0,11	heme_oxygenase-1	64,80	Flunarizine	heme oxygenase-1	MESH:D005444	24451(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|nmod|END_ENTITY	Flunarizine induces Nrf2-mediated transcriptional activation of heme_oxygenase-1 in protection of auditory cells from cisplatin .
10574680	0	Flunitrazepam	0,13	CYP2C19	77,84	Flunitrazepam	CYP2C19	MESH:D005445	1557	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|dep|involvement involvement|nmod|END_ENTITY	Flunitrazepam oxidative metabolism in human liver microsomes : involvement of CYP2C19 and CYP3A4 .
7643631	0	Fluo-3	80,86	P-glycoprotein	13,27	Fluo-3	P-glycoprotein	MESH:C059715	5243	Chemical	Gene	using|dobj|START_ENTITY END_ENTITY|acl|using	Detection of P-glycoprotein with a rapid flow cytometric functional assay using Fluo-3 : evaluation of sensitivity , specificity and feasibility in multiparametric analysis .
19284324	0	Fluocinolone	0,12	VEGF	22,26	Fluocinolone	VEGF	MESH:C035394	7422	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Fluocinolone inhibits VEGF expression via glucocorticoid_receptor in human retinal pigment epithelial -LRB- ARPE-19 -RRB- cells and TNF-alpha-induced angiogenesis in chick_chorioallantoic_membrane -LRB- CAM -RRB- .
19284324	0	Fluocinolone	0,12	glucocorticoid_receptor	42,65	Fluocinolone	glucocorticoid receptor	MESH:C035394	2908	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Fluocinolone inhibits VEGF expression via glucocorticoid_receptor in human retinal pigment epithelial -LRB- ARPE-19 -RRB- cells and TNF-alpha-induced angiogenesis in chick_chorioallantoic_membrane -LRB- CAM -RRB- .
16665312	1	Fluoride	80,88	ATPase	92,98	Fluoride	ATPase	MESH:D005459	1769	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|Activity Activity|compound|END_ENTITY	Effects of Fluoride on ATPase Activity and Transport .
26055717	0	Fluoride	41,49	FEX1	6,10	Fluoride	FEX1	MESH:D005459	854572(Tax:4932)	Chemical	Gene	Channel|compound|START_ENTITY Channel|nsubj|END_ENTITY	Yeast FEX1 is a Constitutively Expressed Fluoride Channel with Functional Asymmetry of its Two Homologous Domains .
9437512	0	Fluoride	0,8	IGF-I	47,52	Fluoride	IGF-I	MESH:D005459	24482(Tax:10116)	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|effects effects|nmod|END_ENTITY	Fluoride potentiates the osteogenic effects of IGF-I in aged ovariectomized rats .
26431905	0	Fluoride	0,8	JNK	75,78	Fluoride	JNK	MESH:D005459	26419(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Fluoride induces oxidative damage and SIRT1/autophagy through ROS-mediated JNK signaling .
26381618	0	Fluoride	0,8	Parathyroid_Hormone	19,38	Fluoride	Parathyroid Hormone	MESH:D005459	19226(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|Secretion Secretion|compound|END_ENTITY	Fluoride Modulates Parathyroid_Hormone Secretion in vivo and in vitro .
20399260	0	Fluoride	0,8	THP1	99,103	Fluoride	THP1	MESH:D005459	2736	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Fluoride as a pro-inflammatory factor and inhibitor of ATP bioavailability in differentiated human THP1 monocytic cells .
10959797	0	Fluoride	0,8	caspase-3	30,39	Fluoride	caspase-3	MESH:D005459	836	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|amod|END_ENTITY	Fluoride induces apoptosis by caspase-3 activation in human leukemia HL-60 cells .
9100584	0	Fluoride	0,8	p44mapk	62,69	Fluoride	p44mapk	MESH:D005459	5595	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|nmod|END_ENTITY	Fluoride at mitogenic doses induces a sustained activation of p44mapk , but not p42mapk , in human TE85 osteosarcoma cells .
19679481	0	Fluorinated_indazoles	0,21	nitric_oxide_synthase	55,76	Fluorinated indazoles	nitric oxide synthase	null	4843	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Fluorinated_indazoles as novel selective inhibitors of nitric_oxide_synthase -LRB- NOS -RRB- : synthesis and biological evaluation .
19996411	0	Fluorinated_per-acetylated_GalNAc	0,33	PSGL-1	86,92	Fluorinated per-acetylated GalNAc	PSGL-1	null	6404	Chemical	Gene	alters|nsubj|START_ENTITY alters|nmod|END_ENTITY	Fluorinated_per-acetylated_GalNAc metabolically alters glycan structures on leukocyte PSGL-1 and reduces cell binding to selectins .
9556630	0	Fluoroaluminate	0,15	Src	54,57	Fluoroaluminate	Src	MESH:C053629	20779(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|nmod|END_ENTITY	Fluoroaluminate induces activation and association of Src and Pyk2 tyrosine kinases in osteoblastic MC3T3-E1 cells .
10498193	0	Fluorobenzamidrazone	0,20	thrombin	21,29	Fluorobenzamidrazone	thrombin	null	29251(Tax:10116)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Fluorobenzamidrazone thrombin inhibitors : influence of fluorine on enhancing oral absorption .
19714451	0	Fluorocurcumins	0,15	cyclooxygenase-2	19,35	Fluorocurcumins	cyclooxygenase-2	null	19225(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|amod|END_ENTITY	Fluorocurcumins as cyclooxygenase-2 inhibitor : molecular docking , pharmacokinetics and tissue distribution in mice .
25853522	0	Fluorodeoxyglucose	113,131	Hypoxia-Inducible_Factor_1a	68,95	Fluorodeoxyglucose	Hypoxia-Inducible Factor 1a	null	3091	Chemical	Gene	Uptake|nmod|START_ENTITY END_ENTITY|nmod|Uptake	The Effect of Lentiviral Vector-Mediated RNA Interference Targeting Hypoxia-Inducible_Factor_1a on the Uptake of Fluorodeoxyglucose -LRB- -LRB- 18 -RRB- F -RRB- in the Human Pancreatic_Cancer Cell Line , Patu8988 .
25853522	0	Fluorodeoxyglucose	113,131	Hypoxia-Inducible_Factor_1a	68,95	Fluorodeoxyglucose	Hypoxia-Inducible Factor 1a	null	3091	Chemical	Gene	Uptake|nmod|START_ENTITY END_ENTITY|nmod|Uptake	The Effect of Lentiviral Vector-Mediated RNA Interference Targeting Hypoxia-Inducible_Factor_1a on the Uptake of Fluorodeoxyglucose -LRB- -LRB- 18 -RRB- F -RRB- in the Human Pancreatic_Cancer Cell Line , Patu8988 .
16951200	0	Fluorodeoxyuridine	0,18	uracil-DNA_glycosylase	88,110	Fluorodeoxyuridine	uracil-DNA glycosylase	MESH:D005467	7374	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	Fluorodeoxyuridine modulates cellular expression of the DNA base excision repair enzyme uracil-DNA_glycosylase .
19947172	0	Fluorofenidone	0,14	CTGF	42,46	Fluorofenidone	CTGF	MESH:C511655	14219(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Fluorofenidone inhibits TGF-beta1 induced CTGF via MAPK pathways in mouse mesangial cells .
20159052	0	Fluorofenidone	0,14	TNF-alpha	79,88	Fluorofenidone	TNF-alpha	MESH:C511655	21926(Tax:10090)	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|inhibition inhibition|nmod|END_ENTITY	Fluorofenidone protects mice from lethal endotoxemia through the inhibition of TNF-alpha and IL-1beta release .
23256506	0	Fluoroketone	0,12	phospholipase_A2	46,62	Fluoroketone	phospholipase A2	null	151056	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|dep|END_ENTITY	Fluoroketone inhibition of Ca -LRB- 2 + -RRB- - independent phospholipase_A2 through binding pocket association defined by hydrogen/deuterium exchange and molecular_dynamics .
26869881	0	Fluoxetine	0,10	Aquaporin-4	40,51	Fluoxetine	Aquaporin-4	MESH:D005473	25293(Tax:10116)	Chemical	Gene	Requires|nsubj|START_ENTITY Requires|dobj|END_ENTITY	Fluoxetine Requires the Endfeet Protein Aquaporin-4 to Enhance Plasticity of Astrocyte Processes .
21852994	0	Fluoxetine	0,10	Bcl-xL	24,30	Fluoxetine	Bcl-xL	MESH:D005473	24888(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|Expression Expression|compound|END_ENTITY	Fluoxetine Up-Regulates Bcl-xL Expression in Rat C6 Glioma Cells .
26340669	0	Fluoxetine	0,10	CES1	19,23	Fluoxetine	CES1	MESH:D005473	1066	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|iobj|END_ENTITY	Fluoxetine reduces CES1 , CES2 , and CYP3A4 expression through decreasing PXR and increasing DEC1 in HepG2 cells .
24569517	0	Fluoxetine	0,10	CYP2D6	117,123	Fluoxetine	CYP2D6	MESH:D005473	1565	Chemical	Gene	interactions|amod|START_ENTITY interactions|dep|correlation correlation|nmod|effects effects|nmod|END_ENTITY	Fluoxetine - and norfluoxetine-mediated complex drug-drug interactions : in vitro to in vivo correlation of effects on CYP2D6 , CYP2C19 , and CYP3A4 .
23565802	0	Fluoxetine	0,10	CYP3A4	25,31	Fluoxetine	CYP3A4	MESH:D005473	1576	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Fluoxetine inhibition of CYP3A4 potentiating adrenal suppression and peptic ulcer disease from intra-articular triamcinolone injections .
10812043	0	Fluoxetine	0,10	HSP70	43,48	Fluoxetine	HSP70	MESH:D005473	266759(Tax:10116)	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|dobj|expression expression|compound|END_ENTITY	Fluoxetine prevents PCP - and MK801-induced HSP70 expression in injured limbic cortical neurons of rats .
26494447	0	Fluoxetine	0,10	IL-10	40,45	Fluoxetine	IL-10	MESH:D005473	25325(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|compound|END_ENTITY	Fluoxetine stimulates anti-inflammatory IL-10 cytokine production and attenuates sensory deficits in a rat model of decompression_sickness .
26340669	0	Fluoxetine	0,10	PXR	72,75	Fluoxetine	PXR	MESH:D005473	8856	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|nmod|END_ENTITY	Fluoxetine reduces CES1 , CES2 , and CYP3A4 expression through decreasing PXR and increasing DEC1 in HepG2 cells .
11408041	0	Fluoxetine	0,10	S100beta	57,65	Fluoxetine	S100beta	MESH:D005473	25742(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|content content|nmod|END_ENTITY	Fluoxetine increases the content of neurotrophic protein S100beta in the rat hippocampus .
19409390	0	Fluoxetine	0,10	corticotropin-releasing_factor	38,68	Fluoxetine	corticotropin-releasing factor	MESH:D005473	1392	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|effects effects|nmod|END_ENTITY	Fluoxetine potentiates the effects of corticotropin-releasing_factor on locomotor activity and serotonergic systems in the roughskin newt , Taricha granulosa .
24061129	0	Fluoxetine	0,10	glutathione_reductase	21,42	Fluoxetine	glutathione reductase	MESH:D005473	116686(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|xcomp|END_ENTITY	Fluoxetine decreases glutathione_reductase in erythrocytes of chronically isolated wistar_rats .
22448962	0	Fluoxetine	0,10	hypoxia-inducible_factor-1a	97,124	Fluoxetine	hypoxia-inducible factor-1a	MESH:D005473	29560(Tax:10116)	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|inhibition inhibition|nmod|END_ENTITY	Fluoxetine protects against monocrotaline-induced pulmonary_arterial_remodeling by inhibition of hypoxia-inducible_factor-1a and vascular_endothelial_growth_factor .
26522512	0	Fluoxetine	0,10	mTOR	21,25	Fluoxetine	mTOR	MESH:D005473	21977(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Fluoxetine regulates mTOR signalling in a region-dependent manner in depression-like mice .
19189865	0	Fluoxetine	0,10	serotonin_transporter	38,59	Fluoxetine	serotonin transporter	MESH:D005473	25553(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY modifies|nsubj|treatment modifies|dobj|END_ENTITY	Fluoxetine treatment to rats modifies serotonin_transporter and cAMP in lymphocytes , CD4 + and CD8 + subpopulations and interleukins 2 and 4 .
19641126	0	Fluoxetine	0,10	serotonin_transporter	31,52	Fluoxetine	serotonin transporter	MESH:D005473	6532	Chemical	Gene	START_ENTITY|amod|binding binding|nmod|END_ENTITY	Fluoxetine -LRB- Prozac -RRB- binding to serotonin_transporter is modulated by chloride and conformational changes .
22900600	0	Fluoxetine	0,10	serotonin_transporter	110,131	Fluoxetine	serotonin transporter	MESH:D005473	25553(Tax:10116)	Chemical	Gene	attenuates|amod|START_ENTITY attenuates|dep|involvement involvement|nmod|receptor receptor|compound|END_ENTITY	Fluoxetine attenuates chronic methamphetamine-induced pulmonary_arterial_remodelling : possible involvement of serotonin_transporter and serotonin 1B receptor .
24480874	0	Fluoxetine	0,10	serotonin_transporter	60,81	Fluoxetine	serotonin transporter	MESH:D005473	6532	Chemical	Gene	START_ENTITY|dep|effects effects|nmod|END_ENTITY	Fluoxetine administered to juvenile monkeys : effects on the serotonin_transporter and behavior .
6418046	0	Flurazepam	0,10	CO2	46,49	Flurazepam	CO2	MESH:D005479	717	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|nmod|END_ENTITY	Flurazepam attenuates the arousal response to CO2 during sleep in normal subjects .
23075731	0	Flurbiprofen_axetil	0,19	peroxisome_proliferator-activated_receptor_gamma	71,119	Flurbiprofen axetil	peroxisome proliferator-activated receptor gamma	MESH:C504422	25664(Tax:10116)	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|activation activation|nmod|END_ENTITY	Flurbiprofen_axetil promotes neuroprotection by activation of cerebral peroxisome_proliferator-activated_receptor_gamma after focal cerebral_ischemia in rats .
26147897	0	Fluspirilene	84,96	CDK2	112,116	Fluspirilene	CDK2	MESH:D005484	1017	Chemical	Gene	START_ENTITY|nmod|Inhibitor Inhibitor|compound|END_ENTITY	In Silico Identification and In Vitro and In Vivo Validation of Anti-Psychotic Drug Fluspirilene as a Potential CDK2 Inhibitor and a Candidate Anti-Cancer Drug .
26265743	0	Flutamide	72,81	Androgen_Receptor	42,59	Flutamide	Androgen Receptor	MESH:D005485	367	Chemical	Gene	Antagonist|appos|START_ENTITY Antagonist|compound|END_ENTITY	A Screen of Approved Drugs Identifies the Androgen_Receptor Antagonist , Flutamide , and its Pharmacologically Active Metabolite , 2-Hydroxy-Flutamide , as Heterotropic Activators of CYP 3A In vitro and In vivo .
12762338	0	Fluticasone	0,11	IL-6	20,24	Fluticasone	IL-6	MESH:C065382	3569	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|production production|amod|END_ENTITY	Fluticasone reduces IL-6 and IL-8 production of cystic_fibrosis bronchial epithelial cells via IKK-beta kinase pathway .
18221360	0	Fluvastatin	0,11	Bcl-2	89,94	Fluvastatin	Bcl-2	MESH:C065180	596	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|nmod|END_ENTITY	Fluvastatin reduces oxidative damage in human vascular endothelial cells by upregulating Bcl-2 .
10822898	0	Fluvastatin	0,11	P-selectin	28,38	Fluvastatin	P-selectin	MESH:C065180	6403	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|levels levels|amod|END_ENTITY	Fluvastatin reduces soluble P-selectin and ICAM-1 levels in hypercholesterolemic patients : role of nitric_oxide .
17383753	0	Fluvastatin	0,11	Toll-like_receptor_4	45,65	Fluvastatin	Toll-like receptor 4	MESH:C065180	7099	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|compound|END_ENTITY	Fluvastatin reduces increased blood monocyte Toll-like_receptor_4 expression in whole blood from patients with chronic_heart_failure .
21862649	0	Fluvastatin	0,11	VEGF-A	26,32	Fluvastatin	VEGF-A	MESH:C065180	22339(Tax:10090)	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	Fluvastatin downregulates VEGF-A expression in TNF-a-induced retinal vessel tortuosity .
10988259	0	Fluvastatin	0,11	matrix_metalloproteinase-1	21,47	Fluvastatin	matrix metalloproteinase-1	MESH:C065180	4312	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Fluvastatin inhibits matrix_metalloproteinase-1 expression in human vascular endothelial cells .
15698590	0	Fluvastatin	0,11	nuclear_factor-kappaB	85,106	Fluvastatin	nuclear factor-kappaB	MESH:C065180	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Fluvastatin inhibits the expression of tumor_necrosis_factor-alpha and activation of nuclear_factor-kappaB in human endothelial cells stimulated by C-reactive_protein .
10928471	0	Fluvastatin	0,11	plasminogen_activator_inhibitor_1	42,75	Fluvastatin	plasminogen activator inhibitor 1	MESH:C065180	5054	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Fluvastatin inhibits basal and stimulated plasminogen_activator_inhibitor_1 , but induces tissue type plasminogen activator in cultured human endothelial cells .
10669153	0	Fluvastatin	0,11	thrombomodulin	30,44	Fluvastatin	thrombomodulin	MESH:C065180	7056	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|END_ENTITY	Fluvastatin decreases soluble thrombomodulin in cardiac transplant recipients .
15698590	0	Fluvastatin	0,11	tumor_necrosis_factor-alpha	39,66	Fluvastatin	tumor necrosis factor-alpha	MESH:C065180	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Fluvastatin inhibits the expression of tumor_necrosis_factor-alpha and activation of nuclear_factor-kappaB in human endothelial cells stimulated by C-reactive_protein .
20164019	0	Fluvastatin	0,11	tyrosinase	22,32	Fluvastatin	tyrosinase	MESH:C065180	22173(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|synthesis synthesis|amod|END_ENTITY	Fluvastatin increases tyrosinase synthesis induced by UVB irradiation of B16F10 melanoma cells .
20360626	0	Fluvastatin	0,11	tyrosinase	22,32	Fluvastatin	tyrosinase	MESH:C065180	22173(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|synthesis synthesis|amod|END_ENTITY	Fluvastatin increases tyrosinase synthesis induced by alpha-melanocyte-stimulating_hormone in B16F10 melanoma cells .
25032855	0	Fluvoxamine	0,11	Sigma-1_receptor	50,66	Fluvoxamine	Sigma-1 receptor	MESH:D016666	18391(Tax:10090)	Chemical	Gene	alleviates|amod|START_ENTITY ER|nsubj|alleviates ER|dobj|stress stress|nmod|induction induction|nmod|END_ENTITY	Fluvoxamine alleviates ER stress via induction of Sigma-1_receptor .
8466541	0	Fluvoxamine	0,11	cytochrome_P4501A2	37,55	Fluvoxamine	cytochrome P4501A2	MESH:D016666	1544	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Fluvoxamine is a potent inhibitor of cytochrome_P4501A2 .
8780042	0	Fmoc-aminoacylpyrrolidine-2-nitriles	39,75	prolyl_oligopeptidase	14,35	Fmoc-aminoacylpyrrolidine-2-nitriles	prolyl oligopeptidase	null	19072(Tax:10090)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of prolyl_oligopeptidase by Fmoc-aminoacylpyrrolidine-2-nitriles .
24616563	0	Folate	9,15	Dihydrofolate_Reductase	34,57	Folate	Dihydrofolate Reductase	MESH:D005492	1719	Chemical	Gene	Domain|compound|START_ENTITY Domain|nmod|END_ENTITY	Study on Folate Binding Domain of Dihydrofolate_Reductase in Different Plant species and Human beings .
26269242	0	Folate	84,90	Dihydrofolate_Reductase	4,27	Folate	Dihydrofolate Reductase	MESH:D005492	1719	Chemical	Gene	Status|compound|START_ENTITY Associated|nmod|Status bp|ccomp|Associated bp|nsubj|END_ENTITY	The Dihydrofolate_Reductase 19 bp Polymorphism Is Not Associated with Biomarkers of Folate Status in Healthy Young Adults , Irrespective of Folic_Acid Intake .
25816016	0	Folate	0,6	FOLR1	19,24	Folate	FOLR1	MESH:D005492	2348	Chemical	Gene	Receptor-a|compound|START_ENTITY Receptor-a|appos|END_ENTITY	Folate Receptor-a -LRB- FOLR1 -RRB- Expression and Function in Triple_Negative_Tumors .
25928305	0	Folate	12,18	FOLR1	31,36	Folate	FOLR1	MESH:D005492	2348	Chemical	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	Correction : Folate Receptor-a -LRB- FOLR1 -RRB- Expression and Function in Triple_Negative_Tumors .
25904506	0	Folate	11,17	FRa	30,33	Folate	FRa	MESH:D005492	8061	Chemical	Gene	Receptor-a|compound|START_ENTITY Receptor-a|appos|END_ENTITY	IMGN853 , a Folate Receptor-a -LRB- FRa -RRB- - Targeting Antibody-Drug Conjugate , Exhibits Potent Targeted Antitumor Activity against FRa-Expressing Tumors .
11440783	0	Folate	0,6	MTHFR	75,80	Folate	MTHFR	MESH:D005492	4524	Chemical	Gene	levels|amod|START_ENTITY levels|dep|genotype genotype|appos|END_ENTITY	Folate levels and N -LRB- 5 -RRB- , N -LRB- 10 -RRB- - methylenetetrahydrofolate_reductase genotype -LRB- MTHFR -RRB- in mothers of offspring with neural tube defects : a case-control study .
12430180	0	Folate	0,6	MTHFR	92,97	Folate	MTHFR	MESH:D005492	4524	Chemical	Gene	START_ENTITY|dep|role role|nmod|polymorphisms polymorphisms|nmod|methylenetetrahydrofolate_reductase methylenetetrahydrofolate_reductase|appos|END_ENTITY	Folate and breast_cancer : the role of polymorphisms in methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- .
14717963	0	Folate	0,6	MTHFR	66,71	Folate	MTHFR	MESH:D005492	4524	Chemical	Gene	levels|amod|START_ENTITY levels|appos|methylenetetrahydrofolate_reductase methylenetetrahydrofolate_reductase|appos|END_ENTITY	Folate , homocysteine levels , methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- 677C _ -- > _ T variant , and the risk of myocardial_infarction in young women : effect of female hormones on homocysteine levels .
21334854	0	Folate	0,6	MTHFR	61,66	Folate	MTHFR	MESH:D005492	4524	Chemical	Gene	supplementation|amod|START_ENTITY supplementation|dep|role role|nmod|genotype genotype|amod|END_ENTITY	Folate supplementation in schizophrenia : a possible role for MTHFR genotype .
23125859	0	Folate	0,6	MTHFR	15,20	Folate	MTHFR	MESH:D005492	4524	Chemical	Gene	Intake|compound|START_ENTITY Intake|appos|Polymorphisms Polymorphisms|compound|END_ENTITY	Folate Intake , MTHFR Polymorphisms , and the Risk of Colorectal_Cancer : A Systematic Review and Meta-Analysis .
23227261	0	Folate	0,6	MTHFR	65,70	Folate	MTHFR	MESH:D005492	4524	Chemical	Gene	reductase|amod|START_ENTITY reductase|appos|END_ENTITY	Folate metabolism gene 5,10-methylenetetrahydrofolate reductase -LRB- MTHFR -RRB- is associated with ADHD in myelomeningocele patients .
23295071	0	Folate	0,6	MTHFR	37,42	Folate	MTHFR	MESH:D005492	4524	Chemical	Gene	gene|amod|START_ENTITY polymorphisms|nsubj|gene polymorphisms|dobj|C677T C677T|compound|END_ENTITY	Folate metabolism gene polymorphisms MTHFR C677T and A1298C and risk for Down syndrome offspring : a meta-analysis .
24596472	0	Folate	0,6	MTHFR	45,50	Folate	MTHFR	MESH:D005492	4524	Chemical	Gene	Levels|compound|START_ENTITY Levels|nmod|END_ENTITY	Folate Levels and Polymorphisms in the Genes MTHFR , MTR , and TS in Colorectal_Cancer .
25297611	0	Folate	137,143	MTHFR	93,98	Folate	MTHFR	MESH:D005492	4524	Chemical	Gene	Homocysteine|compound|START_ENTITY Levels|nmod|Homocysteine Genotype|nmod|Levels Genotype|nsubj|Study Study|acl|Find Find|dobj|Relationship Relationship|nmod|C677T C677T|appos|END_ENTITY	A Cross-Sectional Study to Find Out the Relationship of Methylenetetrahydrofolate_Reductase -LRB- MTHFR -RRB- C677T Genotype with Plasma Levels of Folate and Total Homocysteine by Daily Folate Intake in Japanese .
25297611	0	Folate	176,182	MTHFR	93,98	Folate	MTHFR	MESH:D005492	4524	Chemical	Gene	Intake|compound|START_ENTITY Genotype|nmod|Intake Genotype|nsubj|Study Study|acl|Find Find|dobj|Relationship Relationship|nmod|C677T C677T|appos|END_ENTITY	A Cross-Sectional Study to Find Out the Relationship of Methylenetetrahydrofolate_Reductase -LRB- MTHFR -RRB- C677T Genotype with Plasma Levels of Folate and Total Homocysteine by Daily Folate Intake in Japanese .
25302494	0	Folate	58,64	MTHFR	88,93	Folate	MTHFR	MESH:D005492	4524	Chemical	Gene	Explain|compound|START_ENTITY Women|nmod|Explain Methylation|nmod|Women Degree|nmod|Methylation Associated|nsubj|Degree Associated|compound|END_ENTITY	A Lower Degree of PBMC L1 Methylation in Women with Lower Folate Status May Explain the MTHFR C677T Polymorphism Associated Higher Risk of CIN in the US Post Folic Acid Fortification Era .
25422209	0	Folate	0,6	MTHFR	20,25	Folate	MTHFR	MESH:D005492	4524	Chemical	Gene	Polymorphism|compound|START_ENTITY Polymorphism|compound|END_ENTITY	Folate Pathway Gene MTHFR C677T Polymorphism and Risk of Lung_Cancer in Asian Populations .
25758986	0	Folate	0,6	MTHFR	37,42	Folate	MTHFR	MESH:D005492	4524	Chemical	Gene	gene|amod|START_ENTITY polymorphisms|nsubj|gene polymorphisms|dobj|C677T C677T|compound|END_ENTITY	Folate metabolism gene polymorphisms MTHFR C677T and A1298C and risk for preeclampsia : a meta-analysis .
26140186	0	Folate	23,29	MTHFR	75,80	Folate	MTHFR	MESH:D005492	4524	Chemical	Gene	Intake|compound|START_ENTITY Intake|appos|C677T C677T|appos|END_ENTITY	Maternal Supplementary Folate Intake , Methylenetetrahydrofolate_Reductase -LRB- MTHFR -RRB- C677T and A1298C Polymorphisms and the Risk of Orofacial Cleft in Iranian Children .
26140186	0	Folate	23,29	MTHFR	75,80	Folate	MTHFR	MESH:D005492	4524	Chemical	Gene	Intake|compound|START_ENTITY Intake|appos|C677T C677T|appos|END_ENTITY	Maternal Supplementary Folate Intake , Methylenetetrahydrofolate_Reductase -LRB- MTHFR -RRB- C677T and A1298C Polymorphisms and the Risk of Orofacial Cleft in Iranian Children .
26561410	0	Folate	120,126	MTHFR	89,94	Folate	MTHFR	MESH:D005492	4524	Chemical	Gene	Status|compound|START_ENTITY Polymorphism|nmod|Status Polymorphisms|dep|Polymorphism Polymorphisms|dep|Effect Effect|nmod|_ _|amod|END_ENTITY	Common Polymorphisms That Affect Folate Transport or Metabolism Modify the Effect of the MTHFR 677C _ > _ T Polymorphism on Folate Status .
26561410	0	Folate	33,39	MTHFR	89,94	Folate	MTHFR	MESH:D005492	4524	Chemical	Gene	Transport|compound|START_ENTITY Polymorphisms|dep|Transport Polymorphisms|dep|Effect Effect|nmod|_ _|amod|END_ENTITY	Common Polymorphisms That Affect Folate Transport or Metabolism Modify the Effect of the MTHFR 677C _ > _ T Polymorphism on Folate Status .
14717963	0	Folate	0,6	methylenetetrahydrofolate_reductase	29,64	Folate	methylenetetrahydrofolate reductase	MESH:D005492	4524	Chemical	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Folate , homocysteine levels , methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- 677C _ -- > _ T variant , and the risk of myocardial_infarction in young women : effect of female hormones on homocysteine levels .
16178442	0	Folate	1,7	monocyte_chemoattractant_protein-1	16,50	Folate	monocyte chemoattractant protein-1	MESH:D005492	24770(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|amod|END_ENTITY	-LSB- Folate reduces monocyte_chemoattractant_protein-1 expression in rats with hyperhomocysteinemia -RSB- .
26310574	0	Folic_acid	0,10	Akt	87,90	Folic acid	Akt	MESH:D005492	11651(Tax:10090)	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Folic_acid promotes the myogenic differentiation of C2C12 murine myoblasts through the Akt signaling pathway .
22611939	0	Folic_acid	1,11	Bcl-2	21,26	Folic acid	Bcl-2	MESH:D005492	24224(Tax:10116)	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|dobj|hypomethylation hypomethylation|compound|END_ENTITY	-LSB- Folic_acid prevents Bcl-2 hypomethylation in rats with hyperhomocysteinemia -RSB- .
16728583	0	Folic_acid	0,10	IGF-I_receptor	40,54	Folic acid	IGF-I receptor	MESH:D005492	3480	Chemical	Gene	modulate|nsubj|START_ENTITY modulate|dobj|expression expression|amod|END_ENTITY	Folic_acid and its metabolites modulate IGF-I_receptor gene expression in colon_cancer cells in a p53-dependent manner .
17868882	0	Folic_acid	0,10	MCP-1	29,34	Folic acid	MCP-1	MESH:D005492	24770(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|iobj|END_ENTITY	Folic_acid reduces chemokine MCP-1 release and expression in rats with hyperhomocystinemia .
25841994	0	Folic_acid	0,10	STAT3	51,56	Folic acid	STAT3	MESH:D005492	6774	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|nmod|END_ENTITY	Folic_acid mediates activation of the pro-oncogene STAT3 via the Folate_Receptor_alpha .
25841994	0	Folic_acid	0,10	STAT3	51,56	Folic acid	STAT3	MESH:D005492	6774	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|nmod|END_ENTITY	Folic_acid mediates activation of the pro-oncogene STAT3 via the Folate_Receptor_alpha .
2036994	0	Follistatin	0,11	activin	26,33	Follistatin	activin	null	83729	Chemical	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Follistatin binds to both activin and inhibin through the common subunit .
23408121	0	Foretinib	0,9	c-MET	19,24	Foretinib	c-MET	MESH:C544831	4233	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Foretinib -LRB- XL880 -RRB- : c-MET inhibitor with activity in papillary_renal_cell_cancer .
22466127	0	Formaldehyde	0,12	TRPV1	26,31	Formaldehyde	TRPV1	MESH:D005557	83810(Tax:10116)	Chemical	Gene	up-regulates|amod|START_ENTITY END_ENTITY|nsubj|up-regulates	Formaldehyde up-regulates TRPV1 through MAPK and PI3K signaling pathways in a rat model of bone_cancer_pain .
26900062	0	Formaldehyde	67,79	TRPV1	109,114	Formaldehyde	TRPV1	MESH:D005557	7442	Chemical	Gene	Bone_Cancer_Pain|compound|START_ENTITY Bone_Cancer_Pain|nmod|Activation Activation|compound|END_ENTITY	New Mechanism of Bone_Cancer_Pain : Tumor Tissue-Derived Endogenous Formaldehyde Induced Bone_Cancer_Pain via TRPV1 Activation .
22085862	0	Formononetin	0,12	ADAM10	91,97	Formononetin	ADAM10	MESH:C007768	102	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|upregulation upregulation|nmod|END_ENTITY	Formononetin protects neurons against hypoxia-induced cytotoxicity through upregulation of ADAM10 and sAbPPa .
16108819	0	Formononetin	0,12	AP-1	125,129	Formononetin	AP-1	MESH:C007768	3726	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Formononetin , a phyto-oestrogen , and its metabolites up-regulate interleukin-4 production in activated T cells via increased AP-1 DNA binding activity .
26575424	0	Formononetin	0,12	FGFR2	22,27	Formononetin	FGFR2	MESH:C007768	25022(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Formononetin , a novel FGFR2 inhibitor , potently inhibits angiogenesis and tumor growth in preclinical models .
1348219	0	Formoterol	0,10	beta_2	30,36	Formoterol	beta 2	MESH:C012629	10242	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Formoterol , a new long-acting beta_2 agonist , inhaled twice daily , in stable asthmatic subjects .
1972599	0	Formoterol	0,10	beta_2	30,36	Formoterol	beta 2	MESH:C012629	10242	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Formoterol , a new long acting beta_2 agonist for inhalation twice daily , compared with salbutamol in the treatment of asthma .
9600780	0	Formoterol	0,10	c-fos	36,41	Formoterol	c-fos	MESH:C012629	2353	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|amod|END_ENTITY	Formoterol and isoproterenol induce c-fos gene expression in osteoblast-like cells by activating beta2-adrenergic receptors .
12222549	0	Formoterol	0,10	chronic_obstructive_pulmonary_disease	23,60	Formoterol	chronic obstructive pulmonary disease	MESH:C012629	260431	Chemical	Gene	therapy|amod|START_ENTITY therapy|nmod|END_ENTITY	Formoterol therapy for chronic_obstructive_pulmonary_disease : a review of the literature .
2544117	0	Formoterol_fumarate	0,19	beta_2-adrenoceptor	27,46	Formoterol fumarate	beta 2-adrenoceptor	MESH:C012629	154	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Formoterol_fumarate , a new beta_2-adrenoceptor agonist .
26378785	0	Formyl	59,65	FPR1	84,88	Formyl	FPR1	CHEBI:42485	14293(Tax:10090)	Chemical	Gene	Receptor|compound|START_ENTITY Receptor|appos|END_ENTITY	Gliadin Induces Neutrophil Migration via Engagement of the Formyl Peptide Receptor , FPR1 .
8147868	0	Formylmethanofuran	0,18	dehydrogenase	51,64	Formylmethanofuran	dehydrogenase	MESH:C050842	9704029	Chemical	Gene	synthesis|compound|START_ENTITY END_ENTITY|nsubj|synthesis	Formylmethanofuran synthesis by formylmethanofuran dehydrogenase from Methanobacterium_thermoautotrophicum_Marburg .
25902045	0	Forskolin	0,9	Actinin_4	71,80	Forskolin	Actinin 4	MESH:D005576	81	Chemical	Gene	Channel|compound|START_ENTITY Channel|nmod|END_ENTITY	Forskolin Regulates L-Type Calcium Channel through Interaction between Actinin_4 and b3 Subunit in Osteoblasts .
14709151	0	Forskolin	0,9	CYP19	34,39	Forskolin	CYP19	MESH:D005576	1588	Chemical	Gene	START_ENTITY|dobj|activity activity|appos|END_ENTITY	Forskolin up-regulates aromatase -LRB- CYP19 -RRB- activity and gene transcripts in the human adrenocortical_carcinoma cell line H295R .
15817919	0	Forskolin	0,9	CYP19	62,67	Forskolin	CYP19	MESH:D005576	1588	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|appos|END_ENTITY	Forskolin and dexamethasone synergistically induce aromatase -LRB- CYP19 -RRB- expression in the human osteoblastic cell line SV-HFO .
12022018	0	Forskolin	0,9	NOS	26,29	Forskolin	NOS	MESH:D005576	4842	Chemical	Gene	upregulation|compound|START_ENTITY upregulation|nmod|expression expression|compound|END_ENTITY	Forskolin upregulation of NOS I protein expression in porcine ciliary processes : a new aspect of aqueous_humor regulation .
6540196	0	Forskolin	0,9	VIP	81,84	Forskolin	VIP	MESH:D005576	7432	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|parataxis|interaction interaction|nmod|END_ENTITY	Forskolin stimulates adenylate cyclase in human colonic crypts : interaction with VIP .
16924422	0	Forskolin	0,9	acetylcholinesterase	44,64	Forskolin	acetylcholinesterase	MESH:D005576	11423(Tax:10090)	Chemical	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|amod|END_ENTITY	Forskolin , an inducer of cAMP , up-regulates acetylcholinesterase expression and protects against organophosphate exposure in neuro 2A cells .
9922228	0	Forskolin	0,9	cyclin_D1	19,28	Forskolin	cyclin D1	MESH:D005576	524530(Tax:9913)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Forskolin inhibits cyclin_D1 expression in cultured airway smooth-muscle cells .
12401517	0	Forskolin	0,9	insulin	21,28	Forskolin	insulin	MESH:D005576	3630	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|transcription transcription|compound|END_ENTITY	Forskolin suppresses insulin gene transcription in islet beta-cells through a protein kinase A-independent pathway .
6207575	0	Forskolin	0,9	neurotensin	40,51	Forskolin	neurotensin	MESH:D005576	299757(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Forskolin inhibits histamine release by neurotensin in the rat perfused hind limb .
10620710	0	Forskolin	0,9	rPer1	47,52	Forskolin	rPer1	MESH:D005576	287422(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Forskolin induces circadian gene expression of rPer1 , rPer2 and dbp in mammalian rat-1 fibroblasts .
11854791	0	Fosinopril	37,47	ACE	105,108	Fosinopril	ACE	MESH:D017328	1636	Chemical	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|Patients Patients|nmod|History History|nmod|Cough Cough|compound|END_ENTITY	A Comparison of the Cough Profile of Fosinopril and Enalapril in Hypertensive Patients with a History of ACE Inhibitor-Associated Cough .
22107891	0	Fosinopril	0,10	ACE	62,65	Fosinopril	ACE	MESH:D017328	11421(Tax:10090)	Chemical	Gene	START_ENTITY|appos|angiotensin-converting_enzyme angiotensin-converting_enzyme|appos|END_ENTITY	Fosinopril and zofenopril , two angiotensin-converting_enzyme -LRB- ACE -RRB- inhibitors , potentiate the anticonvulsant activity of antiepileptic_drugs against audiogenic_seizures in DBA/2 mice .
21051829	0	Fosinopril	0,10	Klotho	60,66	Fosinopril	Klotho	MESH:D017328	83504(Tax:10116)	Chemical	Gene	intervention|compound|START_ENTITY intervention|nmod|END_ENTITY	Fosinopril and valsartan intervention in gene expression of Klotho , MMP-9 , TIMP-1 , and PAI-1 in the kidney of spontaneously hypertensive rats .
1283429	0	Fosinopril	0,10	angiotensin-converting_enzyme	32,61	Fosinopril	angiotensin-converting enzyme	MESH:D017328	1636	Chemical	Gene	START_ENTITY|dep|generation generation|nmod|inhibitors inhibitors|amod|END_ENTITY	Fosinopril : a new generation of angiotensin-converting_enzyme inhibitors .
2481187	0	Fosinopril	0,10	angiotensin_I_converting_enzyme	43,74	Fosinopril	angiotensin I converting enzyme	MESH:D017328	24310(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Fosinopril , a phosphinic_acid inhibitor of angiotensin_I_converting_enzyme : in vitro and preclinical in vivo pharmacology .
21646815	0	Fosinopril	0,10	klotho	33,39	Fosinopril	klotho	MESH:D017328	83504(Tax:10116)	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|gene gene|compound|END_ENTITY	Fosinopril and losartan regulate klotho gene and nicotinamide_adenine_dinucleotide_phosphate oxidase expression in kidneys of spontaneously hypertensive rats .
25748087	0	Fostamatinib	42,54	Spleen_Tyrosine_Kinase	14,36	Fostamatinib	Spleen Tyrosine Kinase	MESH:C523665	6850	Chemical	Gene	Targeting|nmod|START_ENTITY Targeting|dobj|END_ENTITY	Targeting the Spleen_Tyrosine_Kinase with Fostamatinib as a Strategy Against Waldenstr m 's Macroglobulinemia .
19333898	0	Fostamatinib	0,12	Syk	16,19	Fostamatinib	Syk	MESH:C523665	6850	Chemical	Gene	START_ENTITY|dep|prodrug prodrug|nsubj|inhibitor inhibitor|compound|END_ENTITY	Fostamatinib , a Syk inhibitor prodrug for the treatment of inflammatory diseases .
10652441	0	Fractalkine	0,11	TNF-alpha	22,31	Fractalkine	TNF-alpha	MESH:D054428	24835(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|secretion secretion|amod|END_ENTITY	Fractalkine modulates TNF-alpha secretion and neurotoxicity induced by microglial activation .
17060465	0	Francisella_acid	10,26	AcpA	0,4	Francisella acid	AcpA	null	5657	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|nsubj|END_ENTITY	AcpA is a Francisella_acid phosphatase that affects intramacrophage survival and virulence .
24525020	0	Fructose	0,8	GLP-1	20,25	Fructose	GLP-1	MESH:D005632	14526(Tax:10090)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Fructose stimulates GLP-1 but not GIP secretion in mice , rats , and humans .
12820898	0	Fructose	0,8	GLUT5	19,24	Fructose	GLUT5	MESH:D005632	6518	Chemical	Gene	stability|compound|START_ENTITY stability|compound|END_ENTITY	Fructose modulates GLUT5 mRNA stability in differentiated Caco-2 cells : role of cAMP-signalling pathway and PABP -LRB- polyadenylated-binding_protein -RRB- - interacting protein -LRB- Paip -RRB- _ 2 .
15362482	0	Fructose	0,8	GLUT5	79,84	Fructose	GLUT5	MESH:D005632	65197(Tax:10116)	Chemical	Gene	transport|amod|START_ENTITY transport|dep|activity activity|compound|END_ENTITY	Fructose transport and metabolism in adipose tissue of Zucker rats : diminished GLUT5 activity during obesity and insulin resistance .
1634504	0	Fructose	0,8	GLUT5	65,70	Fructose	GLUT5	MESH:D005632	6518	Chemical	Gene	transporter|amod|START_ENTITY END_ENTITY|nsubj|transporter	Fructose transporter in human spermatozoa and small intestine is GLUT5 .
21165569	0	Fructose	0,8	GLUT5	21,26	Fructose	GLUT5	MESH:D005632	6518	Chemical	Gene	START_ENTITY|dobj|expression expression|compound|END_ENTITY	Fructose transporter GLUT5 expression in clear_renal_cell_carcinoma .
24918004	0	Fructose	0,8	GLUT5	22,27	Fructose	GLUT5	MESH:D005632	6518	Chemical	Gene	transporters|nsubj|START_ENTITY transporters|dobj|expression expression|compound|END_ENTITY	Fructose transporters GLUT5 and GLUT2 expression in adult patients with fructose intolerance .
9686924	0	Fructose	0,8	GLUT5	35,40	Fructose	GLUT5	MESH:D005632	65197(Tax:10116)	Chemical	Gene	uptake|amod|START_ENTITY uptake|dep|expression expression|nummod|END_ENTITY	Fructose uptake in rat adipocytes : GLUT5 expression and the effects of streptozotocin-induced diabetes .
18508964	0	Fructose	0,8	ICAM-1	43,49	Fructose	ICAM-1	MESH:D005632	25464(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Fructose induces the inflammatory molecule ICAM-1 in endothelial cells .
23016136	0	Fructose	0,8	PAI-1	67,72	Fructose	PAI-1	MESH:D005632	24617(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY production|appos|END_ENTITY	Fructose rich diet-induced high plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- production in the adult female rat : protective effect of progesterone .
20934606	0	Fructose	0,8	adiponectin	16,27	Fructose	adiponectin	MESH:D005632	9370	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|expression expression|compound|END_ENTITY	Fructose alters adiponectin , haptoglobin and angiotensinogen gene expression in 3T3-L1 adipocytes .
26358358	7	Fructose	1477,1485	apolipoprotein_B	1521,1537	Fructose	apolipoprotein B	MESH:D005632	338	Chemical	Gene	had|nsubj|START_ENTITY had|dobj|effect effect|nmod|END_ENTITY	Fructose had no effect on LDL-C , non-HDL-C , apolipoprotein_B , triglycerides , or HDL-C in isocaloric trials .
26417408	0	Fructose	0,8	glucose-dependent_insulinotropic_polypeptide	17,61	Fructose	glucose-dependent insulinotropic polypeptide	MESH:D005632	14607(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|secretion secretion|compound|END_ENTITY	Fructose induces glucose-dependent_insulinotropic_polypeptide , glucagon-like_peptide-1 and insulin secretion : Role of adenosine_triphosphate-sensitive K -LRB- + -RRB- channels .
15723702	0	Fructose	0,8	insulin	10,17	Fructose	insulin	MESH:D005632	3630	Chemical	Gene	START_ENTITY|appos|resistance resistance|compound|END_ENTITY	Fructose , insulin resistance , and metabolic_dyslipidemia .
5086141	0	Fructose	0,8	insulin	25,32	Fructose	insulin	MESH:D005632	3630	Chemical	Gene	START_ENTITY|dobj|potentiation potentiation|nmod|secretion secretion|compound|END_ENTITY	Fructose potentiation of insulin secretion .
23016136	0	Fructose	0,8	plasminogen_activator_inhibitor-1	32,65	Fructose	plasminogen activator inhibitor-1	MESH:D005632	24617(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY production|compound|END_ENTITY	Fructose rich diet-induced high plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- production in the adult female rat : protective effect of progesterone .
3746225	0	Fructose-6-phosphate	0,20	glucose-6-phosphate_dehydrogenase	44,77	Fructose-6-phosphate	glucose-6-phosphate dehydrogenase	MESH:C027618	855480(Tax:4932)	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Fructose-6-phosphate is not a substrate for glucose-6-phosphate_dehydrogenase .
6375797	0	Frusemide	0,9	renin	19,24	Frusemide	renin	MESH:D005665	24715(Tax:10116)	Chemical	Gene	releases|nsubj|START_ENTITY releases|dobj|END_ENTITY	Frusemide releases renin in the rat kidney when prostacyclin synthesis is suppressed .
26190891	0	Fucoidan	31,39	ASK1	107,111	Fucoidan	ASK1	MESH:C007789	4217	Chemical	Gene	Activity|nmod|START_ENTITY Activity|nmod|END_ENTITY	Anti-Proliferation Activity of Fucoidan in MKN45 Gastric_Cancer Cells and Downregulation of Phosphorylated ASK1 , a Cell Cycle-Regulated Kinase .
3021129	0	Fucosterol	0,10	angiotensin_converting_enzyme	21,50	Fucosterol	angiotensin converting enzyme	MESH:C015896	509484(Tax:9913)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|levels levels|amod|END_ENTITY	Fucosterol decreases angiotensin_converting_enzyme levels with reduction of glucocorticoid receptors in endothelial cells .
20594983	0	Fucoxanthin	0,11	Bcl-xL	83,89	Fucoxanthin	Bcl-xL	MESH:C025164	598	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|pathway pathway|amod|END_ENTITY	Fucoxanthin induces apoptosis in human leukemia HL-60 cells through a ROS-mediated Bcl-xL pathway .
22399598	0	Fucoxanthin	0,11	GADD45A	20,27	Fucoxanthin	GADD45A	MESH:C025164	1647	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Fucoxanthin induces GADD45A expression and G1 arrest with SAPK/JNK activation in LNCap human prostate_cancer cells .
21919437	0	Fucoxanthin	0,11	HO-1	21,25	Fucoxanthin	HO-1	MESH:C025164	15368(Tax:10090)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	Fucoxanthin enhances HO-1 and NQO1 expression in murine hepatic BNL_CL .2 cells through activation of the Nrf2/ARE system partially by its pro-oxidant activity .
22363234	0	Fucoxanthin	0,11	cytochrome_P450_3A4	40,59	Fucoxanthin	cytochrome P450 3A4	MESH:C025164	1576	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|END_ENTITY	Fucoxanthin attenuates rifampin-induced cytochrome_P450_3A4 -LRB- CYP3A4 -RRB- and multiple_drug_resistance_1 -LRB- MDR1 -RRB- gene expression through pregnane_X_receptor -LRB- PXR -RRB- - mediated pathways in human hepatoma HepG2 and colon_adenocarcinoma LS174T cells .
25187415	0	Fucoxanthin	0,11	p21	102,105	Fucoxanthin	p21	MESH:C025164	1026	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|up-regulation up-regulation|nmod|END_ENTITY	Fucoxanthin induces growth_arrest and apoptosis in human bladder_cancer T24 cells by up-regulation of p21 and down-regulation of mortalin .
19053887	0	Fudosteine	0,10	mucin	22,27	Fudosteine	mucin	MESH:C113797	100508689	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Fudosteine effects on mucin production .
10556911	0	Fumagillin	141,151	Ets-1	85,90	Fumagillin	Ets-1	MESH:C026211	396235(Tax:9031)	Chemical	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	Inhibition of Angiogenesis In Vivo by ets-1 Antisense Oligonucleotides-Inhibition of Ets-1 Transcription Factor Expression by the Antibiotic Fumagillin .
10556911	0	Fumagillin	141,151	ets-1	38,43	Fumagillin	ets-1	MESH:C026211	396235(Tax:9031)	Chemical	Gene	Expression|nmod|START_ENTITY Inhibition|nmod|Expression Inhibition|nmod|Vivo Vivo|nmod|Oligonucleotides-Inhibition Oligonucleotides-Inhibition|amod|END_ENTITY	Inhibition of Angiogenesis In Vivo by ets-1 Antisense Oligonucleotides-Inhibition of Ets-1 Transcription Factor Expression by the Antibiotic Fumagillin .
10851042	0	Fumaric_acid	0,12	lipoxygenase	54,66	Fumaric acid	lipoxygenase	MESH:C032005	543232(Tax:4565)	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Fumaric_acid is a competitive inhibitor of wheat germ lipoxygenase .
24098549	0	Fumaric_acid_esters	0,19	HIF-1a	65,71	Fumaric acid esters	HIF-1a	MESH:D005650	15251(Tax:10090)	Chemical	Gene	stimulate|nsubj|START_ENTITY stimulate|nmod|END_ENTITY	Fumaric_acid_esters stimulate astrocytic VEGF expression through HIF-1a and Nrf2 .
21762706	0	Fumigaclavine_C	0,15	tumor_necrosis_factor_a	25,48	Fumigaclavine C	tumor necrosis factor a	MESH:C492995	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	Fumigaclavine_C inhibits tumor_necrosis_factor_a production via suppression of toll-like_receptor_4 and nuclear factor kB activation in macrophages .
25796170	0	Fumosorinone	0,12	PTP1B	22,27	Fumosorinone	PTP1B	null	19246(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Fumosorinone , a novel PTP1B inhibitor , activates insulin signaling in insulin-resistance HepG2 cells and shows anti-diabetic effect in diabetic KKAy mice .
25788143	0	Furanochalcones	57,72	Monoamine_Oxidase-B	90,109	Furanochalcones	Monoamine Oxidase-B	null	4129	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|nmod|END_ENTITY	Pharmacophore Modeling , 3D-QSAR and Molecular Docking of Furanochalcones as Inhibitors of Monoamine_Oxidase-B .
11135058	0	Furosemide	0,10	cyclooxygenase-2	35,51	Furosemide	cyclooxygenase-2	MESH:D005665	29527(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Furosemide stimulates macula densa cyclooxygenase-2 expression in rats .
1053468	0	Furosemide	0,10	renin	22,27	Furosemide	renin	MESH:D005665	5972	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Furosemide and plasma renin activity in essential hypertension .
6785094	3	Furosemide	390,400	renin	485,490	Furosemide	renin	MESH:D005665	5972	Chemical	Gene	change|nsubj|START_ENTITY change|dobj|END_ENTITY	Furosemide -LRB- n = 10 -RRB- , 40 mg i.v. , and upright posture -LRB- n = 8 -RRB- did not change active or inactive renin in the anephric state .
8255723	0	Furosemide	0,10	renin	22,27	Furosemide	renin	MESH:D005665	24715(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	Furosemide stimulates renin expression in the kidneys of salt-supplemented rats .
24799378	0	G19	16,19	epidermal_growth_factor	97,120	G19	epidermal growth factor	null	1950	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	Oligosaccharide G19 inhibits U-87 MG human glioma cells growth in vitro and in vivo by targeting epidermal_growth_factor -LRB- EGF -RRB- and activating p53/p21 signaling .
17334933	0	G20210A	0,7	Prothrombin	8,19	G20210A	Prothrombin	null	2147	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	G20210A Prothrombin gene variant in Turkish patients with angiographically documented coronary_artery_disease .
12505422	8	GAA	1171,1174	GABA	1189,1193	GAA	GAMT	null	14431(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|receptors receptors|compound|END_ENTITY	The interaction of GAA with neuronal GABA -LRB- A -RRB- receptors represents a candidate mechanism explaining neurological_dysfunction in GAMT_deficiency .
19160495	0	GABA	20,24	AgRP	28,32	GABA	AgRP	MESH:D005680	11604(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|neurons neurons|compound|END_ENTITY	Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance .
15681656	0	GABA	35,39	Angiotensin_II	0,14	GABA	Angiotensin II	MESH:D005680	24179(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY attenuates|dobj|release attenuates|nsubj|END_ENTITY	Angiotensin_II attenuates synaptic GABA release and excites paraventricular-rostral ventrolateral medulla output neurons .
19749158	0	GABA	24,28	Angiotensin_II	0,14	GABA	Angiotensin II	MESH:D005680	24179(Tax:10116)	Chemical	Gene	enhances|dobj|START_ENTITY enhances|nsubj|END_ENTITY	Angiotensin_II enhances GABA -LRB- B -RRB- receptor-mediated responses and expression in nucleus tractus solitarii of rats .
10698011	0	GABA	0,4	BDNF	152,156	GABA	BDNF	MESH:D005680	24225(Tax:10116)	Chemical	Gene	elevate|nsubj|START_ENTITY elevate|dobj|levels levels|nmod|nerve_growth_factor nerve_growth_factor|appos|END_ENTITY	GABA -LRB- B -RRB- receptor antagonists elevate both mRNA and protein levels of the neurotrophins nerve_growth_factor -LRB- NGF -RRB- and brain-derived_neurotrophic_factor -LRB- BDNF -RRB- but not neurotrophin-3 -LRB- NT-3 -RRB- in brain and spinal cord of rats .
10876028	0	GABA	49,53	BDNF	103,107	GABA	BDNF	MESH:D005680	24225(Tax:10116)	Chemical	Gene	manipulation|nmod|START_ENTITY effects|nmod|manipulation receptors|nsubj|effects receptors|nmod|expression expression|nmod|END_ENTITY	Sex-specific effects of in utero manipulation of GABA -LRB- A -RRB- receptors on pre - and postnatal expression of BDNF in rats .
11298792	0	GABA	83,87	BDNF	0,4	GABA	BDNF	MESH:D005680	24225(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY downregulation|nmod|receptor reduces|nmod|downregulation reduces|nsubj|END_ENTITY	BDNF reduces miniature inhibitory postsynaptic currents by rapid downregulation of GABA -LRB- A -RRB- receptor surface expression .
12163549	0	GABA	22,26	BDNF	36,40	GABA	BDNF	MESH:D005680	627	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Excitatory actions of GABA increase BDNF expression via a MAPK-CREB-dependent mechanism -- a positive feedback circuit in developing neurons .
12359151	0	GABA	69,73	BDNF	0,4	GABA	BDNF	MESH:D005680	24225(Tax:10116)	Chemical	Gene	transmission|compound|START_ENTITY facilitation|nmod|transmission modulates|nmod|facilitation modulates|nsubj|END_ENTITY	BDNF modulates sensory neuron synaptic activity by a facilitation of GABA transmission in the dorsal horn .
12470709	10	GABA	1317,1321	BDNF	1376,1380	GABA	BDNF	MESH:D005680	627	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|nmod|content content|compound|END_ENTITY	In addition , GABA also inhibited the stimulatory effect of glutamate on BDNF peptide content .
15672445	0	GABA	77,81	BDNF	29,33	GABA	BDNF	MESH:D005680	12064(Tax:10090)	Chemical	Gene	underlies|nmod|START_ENTITY underlies|dobj|potentiation potentiation|compound|END_ENTITY	PLCgamma signaling underlies BDNF potentiation of Purkinje cell responses to GABA .
16901909	0	GABA	130,134	BDNF	35,39	GABA	BDNF	MESH:D005680	627	Chemical	Gene	receptor|compound|START_ENTITY Brain-derived_neurotrophic_factor|dep|receptor Brain-derived_neurotrophic_factor|appos|END_ENTITY	Brain-derived_neurotrophic_factor -LRB- BDNF -RRB- - induced synthesis of early_growth_response_factor_3 -LRB- Egr3 -RRB- controls the levels of type A GABA receptor alpha 4 subunits in hippocampal neurons .
17074038	0	GABA	34,38	BDNF	79,83	GABA	BDNF	MESH:D005680	12064(Tax:10090)	Chemical	Gene	reduction|nmod|START_ENTITY reduction|nmod|effect effect|nmod|END_ENTITY	Dark-rearing-induced reduction of GABA and GAD and prevention of the effect by BDNF in the mouse retina .
17074039	0	GABA	14,18	BDNF	0,4	GABA	BDNF	MESH:D005680	24225(Tax:10116)	Chemical	Gene	inhibition|compound|START_ENTITY occludes|dobj|inhibition occludes|nsubj|END_ENTITY	BDNF occludes GABA receptor-mediated inhibition of GABA release in rat hippocampal CA1 pyramidal neurons .
17074039	0	GABA	51,55	BDNF	0,4	GABA	BDNF	MESH:D005680	24225(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY inhibition|nmod|release occludes|dobj|inhibition occludes|nsubj|END_ENTITY	BDNF occludes GABA receptor-mediated inhibition of GABA release in rat hippocampal CA1 pyramidal neurons .
19164851	0	GABA	49,53	BDNF	146,150	GABA	BDNF	MESH:D005680	24225(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY receptor|nsubj|expression receptor|nmod|END_ENTITY	Different postischemic protein expression of the GABA -LRB- A -RRB- receptor alpha2 subunit and the plasticity-associated protein MAP1B after treatment with BDNF versus G-CSF in the rat brain .
19244539	0	GABA	109,113	BDNF	151,155	GABA	BDNF	MESH:D005680	24225(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY release|nmod|PKA PKA|compound|END_ENTITY	At immature mossy-fiber-CA3 synapses , correlated presynaptic and postsynaptic activity persistently enhances GABA release and network excitability via BDNF and cAMP-dependent PKA .
19759312	0	GABA	0,4	BDNF	37,41	GABA	BDNF	MESH:D005680	12064(Tax:10090)	Chemical	Gene	triggers|nsubj|START_ENTITY triggers|dobj|release release|amod|END_ENTITY	GABA -LRB- B -RRB- receptor activation triggers BDNF release and promotes the maturation of GABAergic synapses .
20826313	0	GABA	98,102	BDNF	9,13	GABA	BDNF	MESH:D005680	24225(Tax:10116)	Chemical	Gene	inhibition|compound|START_ENTITY suppressing|dobj|inhibition facilitates|advcl|suppressing facilitates|nsubj|END_ENTITY	Elevated BDNF after cocaine withdrawal facilitates LTP in medial prefrontal cortex by suppressing GABA inhibition .
21900885	0	GABA	0,4	BDNF	82,86	GABA	BDNF	MESH:D005680	627	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|advcl|increasing increasing|dobj|levels levels|compound|END_ENTITY	GABA -LRB- A -RRB- receptor blockade enhances memory consolidation by increasing hippocampal BDNF levels .
21969376	0	GABA	50,54	BDNF	35,39	GABA	BDNF	MESH:D005680	24225(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY enhances|dobj|transport enhances|nsubj|Brain-derived_neurotrophic_factor Brain-derived_neurotrophic_factor|appos|END_ENTITY	Brain-derived_neurotrophic_factor -LRB- BDNF -RRB- enhances GABA transport by modulating the trafficking of GABA_transporter-1 -LRB- GAT-1 -RRB- from the plasma membrane of rat cortical astrocytes .
24068823	0	GABA	143,147	BDNF	15,19	GABA	BDNF	MESH:D005680	12064(Tax:10090)	Chemical	Gene	dependent|nmod|START_ENTITY dependent|nsubj|ability ability|nmod|END_ENTITY	The ability of BDNF to modify neurogenesis and depressive-like behaviors is dependent upon phosphorylation of tyrosine residues 365/367 in the GABA -LRB- A -RRB- - receptor y2 subunit .
24853771	0	GABA	90,94	BDNF	8,12	GABA	BDNF	MESH:D005680	12064(Tax:10090)	Chemical	Gene	inhibition|compound|START_ENTITY reducing|dobj|inhibition enhances|advcl|reducing enhances|nsubj|Loss Loss|nmod|END_ENTITY	Loss of BDNF signaling in D1R-expressing NAc neurons enhances morphine reward by reducing GABA inhibition .
26452489	0	GABA	71,75	BDNF	53,57	GABA	BDNF	MESH:D005680	24225(Tax:10116)	Chemical	Gene	determinant|nmod|START_ENTITY determinant|nmod|actions actions|compound|END_ENTITY	Adenosine_A2A_receptor activation is determinant for BDNF actions upon GABA and glutamate release from rat hippocampal synaptosomes .
18499087	0	GABA	21,25	BNP	14,17	GABA	BNP	MESH:D005680	25105(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY END_ENTITY|nmod|receptors	Modulation by BNP of GABA receptors on ON-type rod bipolar cells is dependent on subcellular sites .
16901909	0	GABA	130,134	Brain-derived_neurotrophic_factor	0,33	GABA	Brain-derived neurotrophic factor	MESH:D005680	627	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|dep|receptor	Brain-derived_neurotrophic_factor -LRB- BDNF -RRB- - induced synthesis of early_growth_response_factor_3 -LRB- Egr3 -RRB- controls the levels of type A GABA receptor alpha 4 subunits in hippocampal neurons .
21969376	0	GABA	50,54	Brain-derived_neurotrophic_factor	0,33	GABA	Brain-derived neurotrophic factor	MESH:D005680	24225(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY enhances|dobj|transport enhances|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor -LRB- BDNF -RRB- enhances GABA transport by modulating the trafficking of GABA_transporter-1 -LRB- GAT-1 -RRB- from the plasma membrane of rat cortical astrocytes .
10087082	0	GABA	107,111	CA1	125,128	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY modulate|dobj|release modulate|nmod|interneurons interneurons|nummod|END_ENTITY	Choline and selective antagonists identify two subtypes of nicotinic acetylcholine receptors that modulate GABA release from CA1 interneurons in rat hippocampal slices .
10465428	0	GABA	27,31	CA1	56,59	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	Alterations|nmod|START_ENTITY synapses|nsubj|Alterations synapses|nmod|interneurons interneurons|compound|END_ENTITY	Alterations of perisomatic GABA synapses on hippocampal CA1 inhibitory interneurons and pyramidal cells in the kainate model of epilepsy .
10561426	0	GABA	70,74	CA1	111,114	GABA	CA1	MESH:D005680	759	Chemical	Gene	transmission|compound|START_ENTITY transmission|nmod|END_ENTITY	Evidence for endogenous excitatory amino_acids as mediators in DSI of GABA -LRB- A -RRB- ergic transmission in hippocampal CA1 .
10587089	0	GABA	19,23	CA1	57,60	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	transmission|compound|START_ENTITY transmission|nmod|END_ENTITY	Late maturation of GABA -LRB- B -RRB- synaptic transmission in area CA1 of the rat hippocampus .
10648698	0	GABA	55,59	CA1	76,79	GABA	CA1	MESH:D005680	759	Chemical	Gene	receptors|compound|START_ENTITY differences|nmod|receptors differences|nmod|cells cells|nummod|END_ENTITY	Kinetic differences between synaptic and extrasynaptic GABA -LRB- A -RRB- receptors in CA1 pyramidal cells .
10741429	0	GABA	22,26	CA1	42,45	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|nmod|neurones neurones|nummod|END_ENTITY	Spontaneously opening GABA -LRB- A -RRB- channels in CA1 pyramidal neurones of rat hippocampus .
10802037	0	GABA	34,38	CA1	71,74	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|nmod|area area|compound|END_ENTITY	Taurine activates GABA -LRB- A -RRB- but not GABA -LRB- B -RRB- receptors in rat hippocampal CA1 area .
11239438	0	GABA	58,62	CA1	66,69	GABA	CA1	MESH:D005680	759	Chemical	Gene	release|nmod|START_ENTITY enhance|dobj|release enhance|nmod|interneurons interneurons|nummod|END_ENTITY	Presynaptic kainate receptors that enhance the release of GABA on CA1 hippocampal interneurons .
11245701	0	GABA	0,4	CA1	54,57	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	receptors|nsubj|START_ENTITY receptors|xcomp|containing containing|ccomp|regulate regulate|nsubj|subunits subunits|nmod|END_ENTITY	GABA -LRB- A -RRB- receptors containing -LRB- alpha -RRB- 5 subunits in the CA1 and CA3 hippocampal fields regulate ethanol-motivated behaviors : an extended ethanol reward circuitry .
11893914	0	GABA	49,53	CA1	109,112	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	cross-inhibition|nmod|START_ENTITY hippocampal|nsubj|cross-inhibition hippocampal|dobj|neurons neurons|nummod|END_ENTITY	State-dependent cross-inhibition between anionic GABA -LRB- A -RRB- and glycine ionotropic receptors in rat hippocampal CA1 neurons .
12438512	0	GABA	67,71	CA1	131,134	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|dep|currents currents|nmod|region region|amod|END_ENTITY	Ethanol antagonizes kainate receptor-mediated inhibition of evoked GABA -LRB- A -RRB- inhibitory postsynaptic currents in the rat hippocampal CA1 region .
12464453	0	GABA	30,34	CA1	89,92	GABA	CA1	MESH:D005680	759	Chemical	Gene	START_ENTITY|acl|mediated mediated|nmod|region region|compound|END_ENTITY	Gamma-hydroxybutyrate reduces GABA -LRB- A -RRB- - mediated inhibitory postsynaptic potentials in the CA1 region of hippocampus .
12558566	0	GABA	27,31	CA1	158,161	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY involved|nsubj|expression involved|nmod|metabolism metabolism|nmod|cells cells|compound|END_ENTITY	Differential expression of GABA and glutamate-receptor subunits and enzymes involved in GABA metabolism between electrophysiologically identified hippocampal CA1 pyramidal cells and interneurons .
12558566	0	GABA	88,92	CA1	158,161	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|nmod|cells cells|compound|END_ENTITY	Differential expression of GABA and glutamate-receptor subunits and enzymes involved in GABA metabolism between electrophysiologically identified hippocampal CA1 pyramidal cells and interneurons .
12562998	0	GABA	75,79	CA1	54,57	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY interneurones|nmod|receptor interneurones|compound|END_ENTITY	Modulation of inhibitory autapses and synapses on rat CA1 interneurones by GABA -LRB- A -RRB- receptor ligands .
12574411	0	GABA	38,42	CA1	102,105	GABA	CA1	MESH:D005680	12346(Tax:10090)	Chemical	Gene	gamma|compound|START_ENTITY Interaction|nmod|gamma produces|nsubj|Interaction produces|nmod|synapses synapses|nummod|END_ENTITY	Interaction of calcineurin and type-A GABA receptor gamma 2 subunits produces long-term depression at CA1 inhibitory synapses .
12640007	0	GABA	22,26	CA1	117,120	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	BDNF|nmod|START_ENTITY currents|amod|BDNF action|nmod|currents changes|nsubj|action changes|advcl|potentiating potentiating|xcomp|suppressing suppressing|nmod|maturation maturation|nmod|neurons neurons|compound|END_ENTITY	The action of BDNF on GABA -LRB- A -RRB- currents changes from potentiating to suppressing during maturation of rat hippocampal CA1 pyramidal neurons .
12763087	0	GABA	11,15	CA1	98,101	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	input|compound|START_ENTITY drives|nsubj|input drives|dobj|synchronization synchronization|nmod|cells cells|compound|END_ENTITY	Excitatory GABA input directly drives seizure-like rhythmic synchronization in mature hippocampal CA1 pyramidal cells .
1337191	0	GABA	32,36	CA1	131,134	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY effect|nmod|uptake Comparison|nmod|effect Comparison|nmod|efficacy efficacy|nmod|neurones neurones|compound|END_ENTITY	Comparison of the effect of the GABA uptake blockers , tiagabine and nipecotic_acid , on inhibitory synaptic efficacy in hippocampal CA1 neurones .
1337196	0	GABA	66,70	CA1	33,36	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	withdrawal|compound|START_ENTITY slices|nmod|withdrawal slices|nsubj|Hyperexcitability Hyperexcitability|nmod|region region|compound|END_ENTITY	Hyperexcitability of hippocampal CA1 region in brain slices after GABA withdrawal .
14550784	0	GABA	14,18	CA1	78,81	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY modulated|nsubjpass|channels modulated|nmod|neurons neurons|nummod|END_ENTITY	Extrasynaptic GABA -LRB- A -RRB- channels activated by THIP are modulated by diazepam in CA1 pyramidal neurons in the rat brain hippocampal slice .
15459240	0	GABA	49,53	CA1	70,73	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY release|nmod|END_ENTITY	The effect of simulated ischaemia on spontaneous GABA release in area CA1 of the juvenile rat hippocampus .
15615867	0	GABA	61,65	CA1	102,105	GABA	CA1	MESH:D005680	759	Chemical	Gene	activity|compound|START_ENTITY activity|nmod|neurons neurons|compound|END_ENTITY	Differential GABAB Receptor Modulation of Ethanol Effects on GABA -LRB- A -RRB- synaptic activity in hippocampal CA1 neurons .
15959457	0	GABA	57,61	CA1	65,68	GABA	CA1	MESH:D005680	759	Chemical	Gene	START_ENTITY|nmod|cells cells|nummod|END_ENTITY	Depressed responses to applied and synaptically-released GABA in CA1 pyramidal cells , but not in CA1 interneurons , after transient forebrain_ischemia .
16154723	0	GABA	11,15	CA1	49,52	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	uptake|nsubj|START_ENTITY uptake|nmod|synapses synapses|nmod|END_ENTITY	Functional GABA uptake at inhibitory synapses in CA1 of chronically epileptic rats .
16248884	0	GABA	72,76	CA1	117,120	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY octanoic_acid|dobj|release octanoic_acid|nmod|interneurons interneurons|acl|projecting projecting|xcomp|END_ENTITY	8 - -LSB- 2 - -LRB- 2-pentyl-cyclopropylmethyl -RRB- - cyclopropyl -RSB- - octanoic_acid stimulates GABA release from interneurons projecting to CA1 pyramidal neurons in the rat hippocampus via pre-synaptic alpha7 acetylcholine receptors .
16342056	0	GABA	12,16	CA1	60,63	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|nmod|terminals terminals|nmod|cells cells|nummod|END_ENTITY	Presynaptic GABA -LRB- B -RRB- receptors on glutamatergic terminals of CA1 pyramidal cells decrease in efficacy after partial hippocampal kindling .
16411229	0	GABA	0,4	CA1	74,77	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY inhibit|nsubj|receptors inhibit|xcomp|backpropagating backpropagating|nmod|cells cells|compound|END_ENTITY	GABA -LRB- B -RRB- receptors inhibit backpropagating dendritic spikes in hippocampal CA1 pyramidal cells in vivo .
1656687	0	GABA	15,19	CA1	101,104	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	Enhancement|nmod|START_ENTITY reduces|nsubj|Enhancement reduces|dobj|loss loss|nmod|cells cells|compound|END_ENTITY	Enhancement of GABA neurotransmission after cerebral_ischemia in the rat reduces loss of hippocampal CA1 pyramidal cells .
16624534	0	GABA	0,4	CA1	33,36	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|nmod|regions regions|compound|END_ENTITY	GABA -LRB- A -RRB- receptors of hippocampal CA1 regions are involved in the acquisition and expression of morphine-induced place preference .
16914680	0	GABA	31,35	CA1	97,100	GABA	CA1	MESH:D005680	759	Chemical	Gene	regulation|nmod|START_ENTITY release|nsubj|regulation release|nmod|cycle cycle|nmod|END_ENTITY	Dynamic regulation of synaptic GABA release by the glutamate-glutamine cycle in hippocampal area CA1 .
17053036	0	GABA	57,61	CA1	144,147	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY origin|nmod|inhibition release|nsubj|origin release|xcomp|pyramidal pyramidal|nmod|region region|compound|END_ENTITY	Postsynaptic origin of CB1-dependent tonic inhibition of GABA release at cholecystokinin-positive basket cell to pyramidal cell synapses in the CA1 region of the rat hippocampus .
17074039	0	GABA	14,18	CA1	83,86	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	inhibition|compound|START_ENTITY occludes|dobj|inhibition occludes|nmod|neurons neurons|compound|END_ENTITY	BDNF occludes GABA receptor-mediated inhibition of GABA release in rat hippocampal CA1 pyramidal neurons .
17074039	0	GABA	51,55	CA1	83,86	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY inhibition|nmod|release occludes|dobj|inhibition occludes|nmod|neurons neurons|compound|END_ENTITY	BDNF occludes GABA receptor-mediated inhibition of GABA release in rat hippocampal CA1 pyramidal neurons .
17687407	0	GABA	89,93	CA1	57,60	GABA	CA1	MESH:D005680	759	Chemical	Gene	Cl|compound|START_ENTITY current|nsubj|Cl potentiating|xcomp|current inhibits|advcl|potentiating inhibits|dobj|activity activity|nmod|neurons neurons|compound|END_ENTITY	Urotensin_II inhibits electrical activity of hippoCampal CA1 neurons by potentiating the GABA -LRB- A -RRB- receptor-mediated Cl -LRB- - -RRB- current .
18030617	0	GABA	48,52	CA1	92,95	GABA	CA1	MESH:D005680	759	Chemical	Gene	immunoreactivities|nmod|START_ENTITY changes|nmod|immunoreactivities course|nmod|changes degradation|nsubj|course degradation|nmod|region region|compound|END_ENTITY	Time course of changes in immunoreactivities of GABA degradation enzymes in the hippocampal CA1 region after adrenalectomy in gerbils .
18272677	0	GABA	110,114	CA1	79,82	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY role|nmod|receptors effects|dep|role effects|nmod|seizures seizures|nmod|signaling signaling|nmod|neurons neurons|nummod|END_ENTITY	Dissociated gender-specific effects of recurrent seizures on GABA signaling in CA1 pyramidal neurons : role of GABA -LRB- A -RRB- receptors .
18272677	0	GABA	61,65	CA1	79,82	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	signaling|compound|START_ENTITY signaling|nmod|neurons neurons|nummod|END_ENTITY	Dissociated gender-specific effects of recurrent seizures on GABA signaling in CA1 pyramidal neurons : role of GABA -LRB- A -RRB- receptors .
18805463	0	GABA	44,48	CA1	103,106	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	reduction|nmod|START_ENTITY receptor-mediated|nsubj|reduction receptor-mediated|nmod|neurons neurons|compound|END_ENTITY	Chronic benzodiazepine-induced reduction in GABA -LRB- A -RRB- receptor-mediated synaptic currents in hippocampal CA1 pyramidal neurons prevented by prior nimodipine injection .
19394921	0	GABA	98,102	CA1	123,126	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY expression|nmod|receptors regulate|dobj|expression regulate|nmod|hippocampus hippocampus|nummod|END_ENTITY	Progesterone and medroxyprogesterone_acetate differentially regulate alpha4 subunit expression of GABA -LRB- A -RRB- receptors in the CA1 hippocampus of female rats .
19428695	0	GABA	157,161	CA1	40,43	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	impact|nmod|START_ENTITY reveal|dobj|impact reveal|nsubj|profiles profiles|nmod|cells cells|nummod|END_ENTITY	Membrane potential response profiles of CA1 pyramidal cells probed with voltage-sensitive_dye optical imaging in rat hippocampal slices reveal the impact of GABA -LRB- A -RRB- - mediated feed-forward inhibition in signal propagation .
19617859	0	GABA	41,45	CA1	106,109	GABA	CA1	MESH:D005680	759	Chemical	Gene	timing|nmod|START_ENTITY control|nmod|timing receptor-mediated|nsubj|control receptor-mediated|nmod|neurons neurons|nummod|END_ENTITY	Bidirectional control of spike timing by GABA -LRB- A -RRB- receptor-mediated inhibition during theta oscillation in CA1 pyramidal neurons .
19879261	0	GABA	32,36	CA1	78,81	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	potential|compound|START_ENTITY plasticity|nmod|potential hippocampal|nsubj|plasticity hippocampal|dobj|neurons neurons|nummod|END_ENTITY	Activity-mediated plasticity of GABA equilibrium potential in rat hippocampal CA1 neurons .
19941877	0	GABA	26,30	CA1	101,104	GABA	CA1	MESH:D005680	12346(Tax:10090)	Chemical	Gene	mediate|nsubj|START_ENTITY mediate|dobj|current current|nmod|neurons neurons|nummod|END_ENTITY	alpha5 Subunit-containing GABA -LRB- A -RRB- receptors mediate a slowly decaying inhibitory synaptic current in CA1 pyramidal neurons following Schaffer collateral activation .
20345910	0	GABA	24,28	CA1	113,116	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY cannabinoid|nsubj|release cannabinoid|nmod|synapses synapses|nmod|END_ENTITY	Asynchronous release of GABA via tonic cannabinoid receptor activation at identified interneuron synapses in rat CA1 .
21453759	0	GABA	60,64	CA1	92,95	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	a-chloralose|nmod|START_ENTITY effects|nmod|a-chloralose release|nsubj|effects release|nmod|neurons neurons|compound|END_ENTITY	Different effects of a-chloralose on spontaneous and evoked GABA release in rat hippocampal CA1 neurons .
2167134	0	GABA	69,73	CA1	130,133	GABA	CA1	MESH:D005680	12346(Tax:10090)	Chemical	Gene	administration|compound|START_ENTITY administration|nmod|dendrites dendrites|nmod|field field|compound|END_ENTITY	-LSB- Tetrodotoxin -- a sensitive component of the depolarizing response to GABA administration to the pyramidal neuron dendrites of the CA1 field of the hippocampus -RSB- .
21799926	0	GABA	25,29	CA1	127,130	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY distributions|nmod|receptors studied|nsubj|distributions studied|xcomp|uncaging uncaging|nmod|dendrites dendrites|nmod|neurons neurons|nummod|END_ENTITY	Spatial distributions of GABA receptors and local inhibition of Ca2 + transients studied with GABA uncaging in the dendrites of CA1 pyramidal neurons .
21799926	0	GABA	93,97	CA1	127,130	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	studied|nmod|START_ENTITY studied|xcomp|uncaging uncaging|nmod|dendrites dendrites|nmod|neurons neurons|nummod|END_ENTITY	Spatial distributions of GABA receptors and local inhibition of Ca2 + transients studied with GABA uncaging in the dendrites of CA1 pyramidal neurons .
22107761	0	GABA	25,29	CA1	103,106	GABA	CA1	MESH:D005680	759	Chemical	Gene	amount|nmod|START_ENTITY correlates|nsubj|amount correlates|nmod|degree degree|nmod|inhibition inhibition|nmod|END_ENTITY	The amount of astrocytic GABA positively correlates with the degree of tonic inhibition in hippocampal CA1 and cerebellum .
22213233	0	GABA	85,89	CA1	159,162	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY levels|nmod|receptor express|iobj|levels express|dobj|a4 a4|nmod|membrane membrane|nmod|spines spines|compound|END_ENTITY	Adolescent female rats exhibiting activity-based anorexia express elevated levels of GABA -LRB- A -RRB- receptor a4 and subunits at the plasma membrane of hippocampal CA1 spines .
23071770	0	GABA	52,56	CA1	83,86	GABA	CA1	MESH:D005680	759	Chemical	Gene	origins|nmod|START_ENTITY origins|dep|excitation excitation|nmod|neurons neurons|nummod|END_ENTITY	Computational modeling reveals dendritic origins of GABA -LRB- A -RRB- - mediated excitation in CA1 pyramidal neurons .
23098796	0	GABA	0,4	CA1	35,38	GABA	CA1	MESH:D005680	12346(Tax:10090)	Chemical	Gene	receptor|nsubj|START_ENTITY receptor|nmod|area area|compound|END_ENTITY	GABA -LRB- A -RRB- receptor activation in the CA1 area of the dorsal hippocampus impairs consolidation of conditioned contextual fear in C57BL/6J mice .
23564259	0	GABA	50,54	CA1	46,49	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	GET73 increases rat extracellular hippocampal CA1 GABA levels through a possible involvement of local mGlu5 receptor .
26389591	0	GABA	14,18	CA1	70,73	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	Equilibrium|compound|START_ENTITY Regulation|nmod|Equilibrium Potential|nsubj|Regulation Potential|nmod|mGluRs mGluRs|nmod|Neurons Neurons|compound|END_ENTITY	Regulation of GABA Equilibrium Potential by mGluRs in Rat Hippocampal CA1 Neurons .
26389591	0	GABA	14,18	CA1	70,73	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	Equilibrium|compound|START_ENTITY Regulation|nmod|Equilibrium Potential|nsubj|Regulation Potential|nmod|mGluRs mGluRs|nmod|Neurons Neurons|compound|END_ENTITY	Regulation of GABA Equilibrium Potential by mGluRs in Rat Hippocampal CA1 Neurons .
26562832	0	GABA	26,30	CA1	82,85	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	Potential|compound|START_ENTITY Potential|nmod|mGluRs mGluRs|nmod|Neurons Neurons|compound|END_ENTITY	Correction : Regulation of GABA Equilibrium Potential by mGluRs in Rat Hippocampal CA1 Neurons .
3008925	0	GABA	137,141	CA1	26,29	GABA	CA1	MESH:D005680	759	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|Loss Loss|nmod|inhibition inhibition|nmod|region region|compound|END_ENTITY	Loss of inhibition in the CA1 region of the kainic_acid lesioned hippocampus is not associated with changes in postsynaptic responses to GABA .
3533598	0	GABA	11,15	CA1	130,133	GABA	CA1	MESH:D005680	759	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|reductions reductions|nmod|calcium calcium|nmod|END_ENTITY	Effects of GABA and bicuculline on N-methyl-D-aspartate - and quisqualate-induced reductions in extracellular free calcium in area CA1 of the hippocampal slice .
6089047	0	GABA	0,4	CA1	71,74	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	reduce|nsubj|START_ENTITY reduce|dobj|changes changes|nmod|calcium calcium|nmod|END_ENTITY	GABA and baclofen reduce changes in extracellular free calcium in area CA1 of rat hippocampal slices .
6266598	0	GABA	26,30	CA1	34,37	GABA	CA1	MESH:D005680	759	Chemical	Gene	response|nmod|START_ENTITY response|nmod|END_ENTITY	The dendritic response to GABA in CA1 of the hippocampal slice .
7472344	0	GABA	69,73	CA1	90,93	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY involvement|nmod|inhibition release|nsubj|involvement release|nmod|END_ENTITY	Calcium channel involvement in GABAB receptor-mediated inhibition of GABA release in area CA1 of the rat hippocampus .
8836210	0	GABA	33,37	CA1	61,64	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	actions|nmod|START_ENTITY actions|nmod|cells cells|nummod|END_ENTITY	Multiple postsynaptic actions of GABA via GABAB receptors on CA1 pyramidal cells of rat hippocampal slices .
8985682	0	GABA	73,77	CA1	94,97	GABA	CA1	MESH:D005680	12346(Tax:10090)	Chemical	Gene	reduction|nmod|START_ENTITY points|nmod|reduction kinetics|nmod|points Analysis|nmod|kinetics release|nsubj|Analysis release|nmod|END_ENTITY	Analysis of the kinetics of synaptic inhibition points to a reduction in GABA release in area CA1 of the genetically epileptic mouse , El .
8994057	0	GABA	61,65	CA1	96,99	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY release|nsubj|inhibition release|nmod|cells cells|compound|END_ENTITY	GABAB receptor-mediated inhibition of tetrodotoxin-resistant GABA release in rodent hippocampal CA1 pyramidal cells .
9109521	0	GABA	78,82	CA1	115,118	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY sensitivity|nmod|receptors increases|dobj|sensitivity increases|nmod|neurons neurons|compound|END_ENTITY	Elevation of basal protein_kinase_C activity increases ethanol sensitivity of GABA -LRB- A -RRB- receptors in rat hippocampal CA1 pyramidal neurons .
9114256	0	GABA	9,13	CA1	99,102	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	inhibition|compound|START_ENTITY reveals|nsubj|inhibition reveals|dobj|responses responses|nmod|region region|compound|END_ENTITY	Blocking GABA -LRB- A -RRB- inhibition reveals AMPA - and NMDA-receptor-mediated polysynaptic responses in the CA1 region of the rat hippocampus .
9114269	0	GABA	35,39	CA1	60,63	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY mediated|nmod|receptors mediated|nmod|neurons neurons|compound|END_ENTITY	Posttetanic excitation mediated by GABA -LRB- A -RRB- receptors in rat CA1 pyramidal neurons .
9223540	0	GABA	27,31	CA1	160,163	GABA	CA1	MESH:D005680	759	Chemical	Gene	transmission|amod|START_ENTITY methylmercury|nmod|transmission Action|nmod|methylmercury responsible|nsubj|Action responsible|nmod|transmission transmission|compound|END_ENTITY	Action of methylmercury on GABA -LRB- A -RRB- receptor-mediated inhibitory synaptic transmission is primarily responsible for its early stimulatory effects on hippocampal CA1 excitatory synaptic transmission .
9284063	0	GABA	19,23	CA1	83,86	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	receptor-mediated|nsubj|START_ENTITY receptor-mediated|ccomp|underlie underlie|dobj|excitability excitability|compound|END_ENTITY	Shortened-duration GABA -LRB- A -RRB- receptor-mediated synaptic potentials underlie enhanced CA1 excitability in a chronic model of temporal_lobe_epilepsy .
9654362	0	GABA	0,4	CA1	54,57	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|transmission transmission|compound|END_ENTITY	GABA -LRB- b -RRB- receptors differentially regulate hippocampal CA1 excitatory synaptic transmission across postnatal development in the rat .
9662142	0	GABA	11,15	CA1	77,80	GABA	CA1	MESH:D005680	759	Chemical	Gene	inhibition|compound|START_ENTITY Effects|nmod|inhibition Effects|nmod|expression expression|nmod|potentiation potentiation|nmod|cells cells|nummod|END_ENTITY	Effects of GABA -LRB- A -RRB- inhibition on the expression of long-term potentiation in CA1 pyramidal cells are dependent on tetanization parameters .
9758157	0	GABA	28,32	CA1	106,109	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	receptor-mediated|nsubj|START_ENTITY receptor-mediated|xcomp|depolarizing depolarizing|nmod|cells cells|compound|END_ENTITY	Neuroactive steroids induce GABA -LRB- A -RRB- receptor-mediated depolarizing postsynaptic potentials in hippocampal CA1 pyramidal cells of the rat .
9769410	0	GABA	22,26	CA1	62,65	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|END_ENTITY	Laminar difference in GABA uptake and GAT-1 expression in rat CA1 .
9839776	0	GABA	18,22	CA1	39,42	GABA	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	loss|nmod|START_ENTITY neurons|nsubj|loss neurons|nmod|END_ENTITY	Selective loss of GABA neurons in area CA1 of the rat hippocampus after intraventricular kainate .
15076763	0	GABA	53,57	CA3	83,86	GABA	CA3	MESH:D005680	54232(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|nmod|END_ENTITY	Inhibition of GABA release by presynaptic ionotropic GABA receptors in hippocampal CA3 .
18216229	0	GABA	0,4	CA3	33,36	GABA	CA3	MESH:D005680	761	Chemical	Gene	actions|compound|START_ENTITY actions|nmod|END_ENTITY	GABA actions in hippocampal area CA3 during postnatal development : differential shift from depolarizing to hyperpolarizing in somatic and dendritic compartments .
20851745	0	GABA	55,59	CREB	70,74	GABA	CREB	MESH:D005680	81646(Tax:10116)	Chemical	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Hypoglycemia induced behavioural deficit and decreased GABA receptor , CREB expression in the cerebellum of streptozoticin induced diabetic rats .
12495621	0	GABA	82,86	Ca2	43,46	GABA	Ca2	MESH:D005680	12349(Tax:10090)	Chemical	Gene	release|nmod|START_ENTITY release|amod|END_ENTITY	Paracrine intercellular communication by a Ca2 + - and SNARE-independent release of GABA and glutamate prior to synapse formation .
12617940	0	GABA	22,26	Ca2	70,73	GABA	Ca2	MESH:D005680	54231(Tax:10116)	Chemical	Gene	actions|nmod|START_ENTITY mediated|nsubjpass|actions mediated|nmod|channels channels|amod|END_ENTITY	Excitatory actions of GABA in developing brain are mediated by l-type Ca2 + channels and dependent on age , sex , and brain region .
2331617	0	GABA	74,78	Ca2	35,38	GABA	Ca2	MESH:D005680	54231(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY increases|dep|release increases|dep|END_ENTITY	Kindling increases the K -LRB- + -RRB- - evoked Ca2 -LRB- + -RRB- - dependent release of endogenous GABA in area CA1 of rat hippocampus .
23974706	0	GABA	0,4	Ca2	81,84	GABA	Ca2	MESH:D005680	54231(Tax:10116)	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|+ +|amod|END_ENTITY	GABA promotes the competitive selection of dendritic spines by controlling local Ca2 + signaling .
8730588	0	GABA	110,114	Ca2	15,18	GABA	Ca2	MESH:D005680	54231(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY activation|nmod|receptors +|nmod|activation +|nsubj|END_ENTITY	High-threshold Ca2 + currents in rat hippocampal interneurones and their selective inhibition by activation of GABA -LRB- B -RRB- receptors .
19332484	0	GABA	30,34	CaMKII	0,6	GABA	CaMKII	MESH:D005680	818	Chemical	Gene	receptor|compound|START_ENTITY phosphorylation|nmod|receptor phosphorylation|compound|END_ENTITY	CaMKII phosphorylation of the GABA -LRB- A -RRB- receptor : receptor subtype - and synapse-specific modulation .
10651144	0	GABA	32,36	Cholecystokinin	0,15	GABA	Cholecystokinin	MESH:D005680	25298(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY increases|dobj|release increases|nsubj|END_ENTITY	Cholecystokinin -LRB- CCK -RRB- increases GABA release in the rat anterior nucleus accumbens via CCK -LRB- B -RRB- receptors located on glutamatergic interneurons .
9185537	0	GABA	26,30	Cholecystokinin	0,15	GABA	Cholecystokinin	MESH:D005680	25298(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY increases|dobj|release increases|nsubj|END_ENTITY	Cholecystokinin increases GABA release by inhibiting a resting K + conductance in hippocampal interneurons .
19036986	0	GABA	41,45	Corticotropin-releasing_factor	0,30	GABA	Corticotropin-releasing factor	MESH:D005680	81648(Tax:10116)	Chemical	Gene	activity|compound|START_ENTITY increases|dobj|activity increases|nsubj|END_ENTITY	Corticotropin-releasing_factor increases GABA synaptic activity and induces inward current in 5-hydroxytryptamine dorsal raphe neurons .
17113947	0	GABA	22,26	Fos	82,85	GABA	Fos	MESH:D005680	314322(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY Zolpidem|appos|receptor induces|nsubj|Zolpidem induces|dobj|expression expression|compound|END_ENTITY	Zolpidem , a selective GABA -LRB- A -RRB- receptor alpha1 subunit agonist , induces comparable Fos expression in oxytocinergic neurons of the hypothalamic paraventricular and accessory but not supraoptic nuclei in the rat .
10448817	0	GABA	80,84	GABA-transaminase	105,122	GABA	GABA-transaminase	MESH:D005680	81632(Tax:10116)	Chemical	Gene	course|nmod|START_ENTITY related|nsubjpass|course related|xcomp|platelet platelet|dobj|inhibition inhibition|amod|END_ENTITY	Time course of the GABAergic effects of vigabatrin : is the time course of brain GABA related to platelet GABA-transaminase inhibition ?
11578600	0	GABA	12,16	GABA-transaminase	56,73	GABA	GABA-transaminase	MESH:D005680	81632(Tax:10116)	Chemical	Gene	rate|compound|START_ENTITY Decrease|nmod|rate Decrease|nmod|cortex cortex|nmod|correlates correlates|amod|END_ENTITY	Decrease in GABA synthesis rate in rat cortex following GABA-transaminase inhibition correlates with the decrease in GAD -LRB- 67 -RRB- protein .
11701133	0	GABA	37,41	GABA-transaminase	93,110	GABA	GABA-transaminase	MESH:D005680	81632(Tax:10116)	Chemical	Gene	synthesis|compound|START_ENTITY synthesis|nmod|neocortex neocortex|nmod|vivo vivo|nmod|inhibition inhibition|amod|END_ENTITY	Glutamine is the major precursor for GABA synthesis in rat neocortex in vivo following acute GABA-transaminase inhibition .
12694932	0	GABA	10,14	GABA-transaminase	31,48	GABA	GABA-transaminase	MESH:D005680	18	Chemical	Gene	Uptake|nmod|START_ENTITY Uptake|nmod|END_ENTITY	Uptake of GABA and activity of GABA-transaminase in platelets from epileptic patients .
16517019	0	GABA	33,37	GABA-transaminase	55,72	GABA	GABA-transaminase	MESH:D005680	81632(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY levels|nmod|inhibition inhibition|amod|END_ENTITY	Acute regulation of steady-state GABA levels following GABA-transaminase inhibition in rat cerebral cortex .
2051176	0	GABA	37,41	GABA-transaminase	100,117	GABA	GABA-transaminase	MESH:D005680	81632(Tax:10116)	Chemical	Gene	identification|nmod|START_ENTITY located|nsubj|identification located|nmod|inhibition inhibition|nmod|END_ENTITY	Immunocytochemical identification of GABA in astrocytes located in white matter after inhibition of GABA-transaminase with gamma-acetylenic_GABA .
3676726	0	GABA	102,106	GABA-transaminase	39,56	GABA	GABA-transaminase	MESH:D005680	81632(Tax:10116)	Chemical	Gene	levels|nmod|START_ENTITY decarboxylase|nmod|levels decarboxylase|nsubj|effects effects|nmod|inactivation inactivation|nmod|END_ENTITY	The effects of in vivo inactivation of GABA-transaminase and glutamic_acid decarboxylase on levels of GABA in the rat retina .
6258106	0	GABA	121,125	GABA-transaminase	88,105	GABA	GABA-transaminase	MESH:D005680	18	Chemical	Gene	increased|dobj|START_ENTITY increased|nsubj|Treatment Treatment|nmod|inhibitor inhibitor|nmod|END_ENTITY	Treatment of Huntington_disease with gamma-acetylenic_GABA an irreversible inhibitor of GABA-transaminase : increased CSF GABA and homocarnosine without clinical amelioration .
6475496	0	GABA	81,85	GABA-transaminase	19,36	GABA	GABA-transaminase	MESH:D005680	81632(Tax:10116)	Chemical	Gene	barrier|nmod|START_ENTITY involvement|nmod|barrier involvement|nmod|END_ENTITY	The involvement of GABA-transaminase in the blood-brain barrier to radiolabelled GABA .
6662342	0	GABA	15,19	GABA-transaminase	98,115	GABA	GABA-transaminase	MESH:D005680	18	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|effect effect|nmod|gamma-acetylenic_GABA gamma-acetylenic_GABA|appos|inhibitor inhibitor|nmod|END_ENTITY	Involvement of GABA in the antinociceptive effect of gamma-acetylenic_GABA -LRB- GAG -RRB- , an inhibitor of GABA-transaminase .
6686689	0	GABA	0,4	GABA-transaminase	52,69	GABA	GABA-transaminase	MESH:D005680	81632(Tax:10116)	Chemical	Gene	START_ENTITY|dep|reversal reversal|acl|overeating overeating|nmod|inhibition inhibition|amod|END_ENTITY	GABA and feeding : reversal of overeating by central GABA-transaminase inhibition .
7914662	0	GABA	15,19	GABA-transaminase	30,47	GABA	GABA-transaminase	MESH:D005680	81632(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|amod|END_ENTITY	Measurement of GABA following GABA-transaminase inhibition by gabaculine : a 1H and 31P NMR spectroscopic study of rat brain in vivo .
8937445	0	GABA	75,79	GABA-transaminase	39,56	GABA	GABA-transaminase	MESH:D005680	81632(Tax:10116)	Chemical	Gene	system|compound|START_ENTITY Effects|nmod|system Effects|nmod|treatment treatment|nmod|inhibitors inhibitors|amod|END_ENTITY	Effects of chronic oral treatment with GABA-transaminase inhibitors on the GABA system in brain , liver , kidney , and plasma of the rat .
9554704	0	GABA	22,26	GABA-transaminase	47,64	GABA	GABA-transaminase	MESH:D005680	18	Chemical	Gene	START_ENTITY|dep|effects effects|nmod|inhibition inhibition|amod|END_ENTITY	Measuring human brain GABA in vivo : effects of GABA-transaminase inhibition with vigabatrin .
15532543	0	GABA	10,14	GABA_transaminase	31,48	GABA	GABA transaminase	MESH:D005680	18	Chemical	Gene	Uptake|nmod|START_ENTITY Uptake|nmod|END_ENTITY	Uptake of GABA and activity of GABA_transaminase in blood platelets from children with absence_epilepsy .
15619231	0	GABA	20,24	GABA_transaminase	114,131	GABA	GABA transaminase	MESH:D005680	81632(Tax:10116)	Chemical	Gene	correlates|compound|START_ENTITY endogenous|dobj|correlates endogenous|nmod|signals signals|nmod|brain brain|nmod|inhibition inhibition|nmod|END_ENTITY	Elevated endogenous GABA level correlates with decreased fMRI signals in the rat brain during acute inhibition of GABA_transaminase .
19540876	0	GABA	21,25	GABA_transaminase	60,77	GABA	GABA transaminase	MESH:D005680	18	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	Detection of reduced GABA synthesis following inhibition of GABA_transaminase using in vivo magnetic resonance signal of -LSB- 13C -RSB- GABA C1 .
2897054	0	GABA	63,67	GABA_transaminase	0,17	GABA	GABA transaminase	MESH:D005680	81632(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY enhance|dobj|release enhance|nsubj|inhibitors inhibitors|amod|END_ENTITY	GABA_transaminase inhibitors enhance the release of endogenous GABA but decrease the release of beta-alanine evoked by electrical stimulation of slices of the rat medulla oblongata .
7722510	0	GABA	141,145	GABA_transaminase	41,58	GABA	GABA transaminase	MESH:D005680	81632(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY gamma-vinyl-GABA|nmod|release inhibitors|dobj|gamma-vinyl-GABA inhibitors|nsubj|effect effect|nmod|treatment treatment|nmod|END_ENTITY	The effect of chronic treatment with the GABA_transaminase inhibitors gamma-vinyl-GABA and ethanolamine-O-sulphate on the in vivo release of GABA from rat hippocampus .
9351512	0	GABA	127,131	GABA_transaminase	37,54	GABA	GABA transaminase	MESH:D005680	81632(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY inhibitors|nmod|release inhibitors|nsubj|Effect Effect|nmod|treatment treatment|nmod|END_ENTITY	Effect of chronic treatment with the GABA_transaminase inhibitors gamma-vinyl_GABA and ethanolamine_O-sulphate on the in vitro GABA release from rat hippocampus .
15229234	0	GABA	0,4	GABA_transporter-1	16,34	GABA	GABA transporter-1	MESH:D005680	50676(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|END_ENTITY	GABA uptake via GABA_transporter-1 modulates GABAergic transmission in the immature hippocampus .
19261879	0	GABA	91,95	GABRA1	108,114	GABA	GABRA1	MESH:D005680	2554	Chemical	Gene	mutation|compound|START_ENTITY mutation|compound|END_ENTITY	Two molecular pathways -LRB- NMD and ERAD -RRB- contribute to a genetic_epilepsy associated with the GABA -LRB- A -RRB- receptor GABRA1 PTC mutation , 975delC , S326fs328X .
12080446	0	GABA	24,28	GABRA6	61,67	GABA	GABRA6	MESH:D005680	2559	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Allelic variants in the GABA -LRB- A -RRB- alpha6 receptor subunit gene -LRB- GABRA6 -RRB- is associated with abdominal_obesity and cortisol secretion .
23864674	0	GABA	95,99	GAD1	90,94	GABA	GAD1	MESH:D005680	14415(Tax:10090)	Chemical	Gene	enzyme|compound|START_ENTITY enzyme|compound|END_ENTITY	Conserved chromosome 2q31 conformations are associated with transcriptional regulation of GAD1 GABA synthesis enzyme and altered in prefrontal cortex of subjects with schizophrenia .
10441235	0	GABA	58,62	GAD65	17,22	GABA	GAD65	MESH:D005680	2572	Chemical	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|END_ENTITY	Up-regulation of GAD65 and GAD67 in remaining hippocampal GABA neurons in a model of temporal_lobe_epilepsy .
10353341	0	GABA	30,34	GAT-1	49,54	GABA	GAT-1	MESH:D005680	6529	Chemical	Gene	transporters|compound|START_ENTITY Immunoreactivity|nmod|transporters Immunoreactivity|appos|END_ENTITY	Immunoreactivity for multiple GABA transporters -LRB- GAT-1 , GAT-2 , GAT-3 -RRB- in the gerbil pineal gland .
10443590	3	GABA	836,840	GAT-1	852,857	GABA	GAT-1	MESH:D005680	6529	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|END_ENTITY	DPB substituted THPO displayed higher inhibitory potency than the parent compound regarding the ability to inhibit GABA uptake via GAT-1 and GAT-2 .
15248296	0	GABA	11,15	GAT-1	103,108	GABA	GAT-1	MESH:D005680	50676(Tax:10116)	Chemical	Gene	transporters|compound|START_ENTITY Changes|nmod|transporters hippocampus|nsubj|Changes hippocampus|dobj|decrease decrease|nmod|END_ENTITY	Changes in GABA transporters in the rat hippocampus after kainate-induced neuronal_injury : decrease in GAT-1 and GAT-3 but upregulation of betaine/GABA transporter BGT-1 .
15365220	0	GABA	0,4	GAT-1	18,23	GABA	GAT-1	MESH:D005680	6529	Chemical	Gene	transporters|nsubj|START_ENTITY transporters|xcomp|END_ENTITY	GABA transporters GAT-1 and GAT-3 in the human dorsolateral prefrontal cortex in schizophrenia .
15821932	0	GABA	31,35	GAT-1	49,54	GABA	GAT-1	MESH:D005680	50676(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY transporters|nsubj|expression transporters|xcomp|END_ENTITY	Differential expression of the GABA transporters GAT-1 and GAT-3 in brains of rats , cats , monkeys and humans .
16766089	0	GABA	18,22	GAT-1	55,60	GABA	GAT-1	MESH:D005680	6529	Chemical	Gene	uptake|compound|START_ENTITY inhibitors|nsubj|uptake inhibitors|xcomp|selective selective|nmod|END_ENTITY	New highly potent GABA uptake inhibitors selective for GAT-1 and GAT-3 derived from -LRB- R -RRB- - _ and _ -LRB- S -RRB- - proline and homologous pyrrolidine-2-alkanoic_acids .
17099065	0	GABA	68,72	GAT-1	101,106	GABA	GAT-1	MESH:D005680	6529	Chemical	Gene	plasma|compound|START_ENTITY express|dobj|plasma distribution|acl:relcl|express membrane|nsubj|distribution membrane|dobj|END_ENTITY	The distribution of chandelier cell axon terminals that express the GABA plasma membrane transporter GAT-1 in the human neocortex .
17298599	0	GABA	28,32	GAT-1	0,5	GABA	GAT-1	MESH:D005680	50676(Tax:10116)	Chemical	Gene	limit|dobj|START_ENTITY acts|xcomp|limit acts|nsubj|END_ENTITY	GAT-1 acts to limit a tonic GABA -LRB- A -RRB- current in rat CA3 pyramidal neurons at birth .
18248614	0	GABA	38,42	GAT-1	0,5	GABA	GAT-1	MESH:D005680	232333(Tax:10090)	Chemical	Gene	inhibition|compound|START_ENTITY regulates|dobj|inhibition regulates|nsubj|END_ENTITY	GAT-1 regulates both tonic and phasic GABA -LRB- A -RRB- receptor-mediated inhibition in the cerebral cortex .
19200339	0	GABA	32,36	GAT-1	101,106	GABA	GAT-1	MESH:D005680	6529	Chemical	Gene	transport|compound|START_ENTITY enhance|dobj|transport enhance|advcl|restraining restraining|dobj|inhibition inhibition|nmod|END_ENTITY	Adenosine A2A receptors enhance GABA transport into nerve terminals by restraining PKC inhibition of GAT-1 .
21503156	0	GABA	32,36	GAT-1	11,16	GABA	GAT-1	MESH:D005680	232333(Tax:10090)	Chemical	Gene	Homeostasis|compound|START_ENTITY Role|nmod|Homeostasis Role|nmod|END_ENTITY	A Role for GAT-1 in Presynaptic GABA Homeostasis ?
21969376	0	GABA	50,54	GAT-1	118,123	GABA	GAT-1	MESH:D005680	50676(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY enhances|dobj|transport enhances|advcl|modulating modulating|dobj|trafficking trafficking|nmod|GABA_transporter-1 GABA_transporter-1|appos|END_ENTITY	Brain-derived_neurotrophic_factor -LRB- BDNF -RRB- enhances GABA transport by modulating the trafficking of GABA_transporter-1 -LRB- GAT-1 -RRB- from the plasma membrane of rat cortical astrocytes .
23090943	0	GABA	11,15	GAT-1	28,33	GABA	GAT-1	MESH:D005680	50676(Tax:10116)	Chemical	Gene	transporter|nsubj|START_ENTITY transporter|dobj|dysfunction dysfunction|compound|END_ENTITY	Astrocytic GABA transporter GAT-1 dysfunction in experimental absence_seizures .
7472524	0	GABA	23,27	GAT-1	0,5	GABA	GAT-1	MESH:D005680	50676(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|appos|transporter	GAT-1 , a high-affinity GABA plasma membrane transporter , is localized to neurons and astroglia in the cerebral cortex .
7823186	0	GABA	22,26	GAT-1	16,21	GABA	GAT-1	MESH:D005680	50676(Tax:10116)	Chemical	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	Localization of GAT-1 GABA transporter mRNA in rat striatum : cellular coexpression with GAD67 mRNA , GAD67 immunoreactivity , and parvalbumin mRNA .
7961138	0	GABA	84,88	GAT-1	46,51	GABA	GAT-1	MESH:D005680	50676(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY limited|nsubjpass|uptake evidence|dep|limited Distribution|dep|evidence Distribution|nmod|mRNA mRNA|nmod|END_ENTITY	Distribution of mRNA for the GABA transporter GAT-1 in the rat brain : evidence that GABA uptake is not limited to presynaptic neurons .
8731228	0	GABA	0,4	GAT-1	35,40	GABA	GAT-1	MESH:D005680	50676(Tax:10116)	Chemical	Gene	transporters|compound|START_ENTITY transporters|amod|END_ENTITY	GABA plasma membrane transporters , GAT-1 and GAT-3 , display different distributions in the rat hippocampus .
9088561	0	GABA	21,25	GAT-1	55,60	GABA	GAT-1	MESH:D005680	50676(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Immunoreactivity for GABA plasma membrane transporter , GAT-1 , in the developing rat cerebral cortex : transient presence in the somata of neocortical and hippocampal neurons .
9261563	0	GABA	50,54	GAT-1	73,78	GABA	GAT-1	MESH:D005680	232333(Tax:10090)	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Characterization of 5 ' - proximal sequence of mouse GABA transporter gene -LRB- GAT-1 -RRB- .
9459570	0	GABA	136,140	GAT-1	153,158	GABA	GAT-1	MESH:D005680	50676(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|dep|transporter	Effects of phenelzine and imipramine on the steady-state levels of mRNAs that encode glutamic_acid decarboxylase -LRB- GAD67 and GAD65 -RRB- , the GABA transporter GAT-1 and GABA_transaminase in rat cortex .
10353341	0	GABA	30,34	GAT-2	56,61	GABA	GAT-2	MESH:D005680	6540	Chemical	Gene	transporters|compound|START_ENTITY Immunoreactivity|nmod|transporters Immunoreactivity|appos|GAT-1 GAT-1|dep|END_ENTITY	Immunoreactivity for multiple GABA transporters -LRB- GAT-1 , GAT-2 , GAT-3 -RRB- in the gerbil pineal gland .
17502375	0	GABA	76,80	GAT-2	101,106	GABA	GAT-2	MESH:D005680	6539	Chemical	Gene	transporter|appos|START_ENTITY transporter|appos|END_ENTITY	Cloning and characterization of a functional human gamma-aminobutyric_acid -LRB- GABA -RRB- transporter , human GAT-2 .
10353341	0	GABA	30,34	GAT-3	63,68	GABA	GAT-3	MESH:D005680	6540	Chemical	Gene	transporters|compound|START_ENTITY Immunoreactivity|nmod|transporters Immunoreactivity|appos|GAT-1 GAT-1|dep|END_ENTITY	Immunoreactivity for multiple GABA transporters -LRB- GAT-1 , GAT-2 , GAT-3 -RRB- in the gerbil pineal gland .
24324407	0	GABA	99,103	GAT-3	120,125	GABA	GAT-3	MESH:D005680	243616(Tax:10090)	Chemical	Gene	release|nsubj|START_ENTITY release|nmod|END_ENTITY	Reduced tonic inhibition in striatal output neurons from Huntington_mice due to loss of astrocytic GABA release through GAT-3 .
8057281	0	GABA	196,200	GAT-3	213,218	GABA	GAT-3	MESH:D005680	6540	Chemical	Gene	affinity|nmod|START_ENTITY ligand|nmod|affinity END_ENTITY|amod|ligand	Design , synthesis and evaluation of substituted triarylnipecotic_acid derivatives as GABA uptake inhibitors : identification of a ligand with moderate affinity and selectivity for the cloned human GABA transporter GAT-3 .
8057281	0	GABA	85,89	GAT-3	213,218	GABA	GAT-3	MESH:D005680	6540	Chemical	Gene	inhibitors|compound|START_ENTITY derivatives|nmod|inhibitors Design|nmod|derivatives Design|dep|identification identification|nmod|END_ENTITY	Design , synthesis and evaluation of substituted triarylnipecotic_acid derivatives as GABA uptake inhibitors : identification of a ligand with moderate affinity and selectivity for the cloned human GABA transporter GAT-3 .
8815906	0	GABA	23,27	GAT-3	0,5	GABA	GAT-3	MESH:D005680	79213(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|appos|transporter	GAT-3 , a high-affinity GABA plasma membrane transporter , is localized to astrocytic processes , and it is not confined to the vicinity of GABAergic synapses in the cerebral cortex .
11248347	0	GABA	25,29	GAT1	43,47	GABA	GAT1	MESH:D005680	50676(Tax:10116)	Chemical	Gene	changes|nmod|START_ENTITY transporter|nsubj|changes transporter|dobj|expressions expressions|appos|END_ENTITY	Developmental changes in GABA transporter -LRB- GAT1 and GAT3 -RRB- mRNA expressions in the rat olfactory bulb .
16683252	0	GABA	30,34	GAT1	58,62	GABA	GAT1	MESH:D005680	232333(Tax:10090)	Chemical	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Mice with genetically altered GABA transporter subtype I -LRB- GAT1 -RRB- expression show altered behavioral responses to ethanol .
19073797	0	GABA	64,68	GAT1	17,21	GABA	GAT1	MESH:D005680	50676(Tax:10116)	Chemical	Gene	synapses|compound|START_ENTITY spillover|nmod|synapses prevents|dobj|spillover prevents|nsubj|END_ENTITY	GABA transporter GAT1 prevents spillover at proximal and distal GABA synapses onto primate prefrontal cortex neurons .
21775701	0	GABA	0,4	GAT1	53,57	GABA	GAT1	MESH:D005680	446294(Tax:8355)	Chemical	Gene	transport|compound|START_ENTITY transport|nmod|END_ENTITY	GABA reverse transport by the neuronal cotransporter GAT1 : influence of internal chloride depletion .
22689508	0	GABA	152,156	GAT1	173,177	GABA	GAT1	MESH:D005680	6529	Chemical	Gene	y-aminobutyric_acid|dep|START_ENTITY transporter_1|amod|y-aminobutyric_acid transporter_1|appos|END_ENTITY	Library screening by means of mass spectrometry -LRB- MS -RRB- binding assays-exemplarily demonstrated for a pseudostatic library addressing y-aminobutyric_acid -LRB- GABA -RRB- _ transporter_1 -LRB- GAT1 -RRB- .
25150942	0	GABA	14,18	GAT1	38,42	GABA	GAT1	MESH:D005680	232333(Tax:10090)	Chemical	Gene	uptake|nsubj|START_ENTITY uptake|nmod|transporters transporters|compound|END_ENTITY	High-affinity GABA uptake by neuronal GAT1 transporters provokes release of -LSB- -LRB- 3 -RRB- H -RSB- GABA by homoexchange and through GAT1-independent Ca -LRB- 2 + -RRB- - mediated mechanisms .
7498491	0	GABA	182,186	GAT1	33,37	GABA	GAT1	MESH:D005680	6529	Chemical	Gene	gamma-aminobutyric_acid|appos|START_ENTITY expressing|dobj|gamma-aminobutyric_acid downregulated|xcomp|expressing downregulated|nsubjpass|END_ENTITY	The recombinant GABA transporter GAT1 is downregulated upon activation of protein kinase C. Treatment of human embryonic kidney 293 cells expressing the rat gamma-aminobutyric_acid -LRB- GABA -RRB- transporter 1 -LRB- GAT1 -RRB- with the protein kinase C -LRB- PKC -RRB- activator phorbol_12-myristate_13-acetate -LRB- PMA -RRB- was found to decrease the velocity of specific -LSB- 3H -RSB- GABA uptake .
7854065	0	GABA	42,46	GAT1	69,73	GABA	GAT1	MESH:D005680	6529	Chemical	Gene	subtypes|compound|START_ENTITY subtypes|appos|END_ENTITY	Production of specific antibodies against GABA transporter subtypes -LRB- GAT1 , GAT2 , GAT3 -RRB- and their application to immunocytochemistry .
8058205	0	GABA	98,102	GAT1	116,120	GABA	GAT1	MESH:D005680	446294(Tax:8355)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Phorbol_ester-induced inhibition of GABA uptake by synaptosomes and by Xenopus oocytes expressing GABA transporter -LRB- GAT1 -RRB- .
8738166	0	GABA	39,43	GAT1	58,62	GABA	GAT1	MESH:D005680	50676(Tax:10116)	Chemical	Gene	transporters|compound|START_ENTITY localization|nmod|transporters localization|appos|END_ENTITY	Neuronal and glial localization of two GABA transporters -LRB- GAT1 and GAT3 -RRB- in the rat cerebellum .
12107427	6	GABA	948,952	GAT2	988,992	GABA	GAT1	MESH:D005680	50676(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|nsubj|transporter	GAT2 was colocalized in these structures with the glial cell marker p75 -LRB- NTR -RRB- , suggesting that the predominant high affinity GABA transporter within enteric glia is GAT2 .
12196556	0	GABA	44,48	GB2	25,28	GABA	GB2	MESH:D005680	9568	Chemical	Gene	receptor|compound|START_ENTITY subunit|nmod|receptor subunit|amod|binding binding|nmod|END_ENTITY	No ligand binding in the GB2 subunit of the GABA -LRB- B -RRB- receptor is required for activation and allosteric interaction between the subunits .
20237276	0	GABA	120,124	Gat1	148,152	GABA	Gat1	MESH:D005680	232333(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY promoter|nmod|transporter module|nmod|promoter Identification|nmod|module subtype|nsubj|Identification subtype|xcomp|gene gene|nsubj|I I|appos|END_ENTITY	Identification of a Smad4/YY1-recognized and BMP2-responsive transcriptional regulatory module in the promoter of mouse GABA transporter subtype I -LRB- Gat1 -RRB- gene .
22516108	0	GABA	147,151	GluK2	107,112	GABA	GluK2	MESH:D005680	54257(Tax:10116)	Chemical	Gene	pathway|nmod|START_ENTITY pathway|amod|END_ENTITY	Neuroprotection of GluK1 kainate receptor agonist ATPA against ischemic_neuronal_injury through inhibiting GluK2 kainate receptor-JNK3 pathway via GABA -LRB- A -RRB- receptors .
17190904	0	GABA	35,39	Glucagon-like_peptide-1	0,23	GABA	Glucagon-like peptide-1	MESH:D005680	24952(Tax:10116)	Chemical	Gene	formation|compound|START_ENTITY stimulates|dobj|formation stimulates|nsubj|END_ENTITY	Glucagon-like_peptide-1 stimulates GABA formation by pancreatic beta-cells at the level of glutamate_decarboxylase .
11029619	0	GABA	33,37	GnRH	71,75	GABA	GnRH	MESH:D005680	14714(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY reorganization|nmod|receptor reorganization|acl|signalling signalling|nmod|neurons neurons|compound|END_ENTITY	Late postnatal reorganization of GABA -LRB- A -RRB- receptor signalling in native GnRH neurons .
11596866	0	GABA	19,23	GnRH	55,59	GABA	GnRH	MESH:D005680	2796	Chemical	Gene	involvement|nmod|START_ENTITY receptors|nsubj|involvement receptors|nmod|control control|nmod|END_ENTITY	The involvement of GABA -LRB- A -RRB- receptors in the control of GnRH and beta-endorphin release , and catecholaminergic activity in the ventromedial-infundibular region of hypothalamus in anestrous ewes .
11694762	0	GABA	35,39	GnRH	122,126	GABA	GnRH	MESH:D005680	14714(Tax:10090)	Chemical	Gene	gamma-aminobutyric_acid|dep|START_ENTITY gamma-aminobutyric_acid|dep|expression expression|nmod|neurons neurons|appos|END_ENTITY	Profiling gamma-aminobutyric_acid -LRB- GABA -LRB- A -RRB- -RRB- receptor subunit mRNA expression in postnatal gonadotropin-releasing_hormone -LRB- GnRH -RRB- neurons of the male mouse with single cell RT-PCR .
11897704	0	GABA	10,14	GnRH	18,22	GABA	GnRH	MESH:D005680	14714(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|neurons neurons|compound|END_ENTITY	Effect of GABA on GnRH neurons switches from depolarization to hyperpolarization at puberty in the female mouse .
12411736	7	GABA	1729,1733	GnRH	1768,1772	GABA	GnRH	MESH:D005680	25194(Tax:10116)	Chemical	Gene	neurons|compound|START_ENTITY involve|dobj|neurons involve|xcomp|generate generate|dobj|release release|compound|END_ENTITY	In light of the in vivo studies performed previously , we suggest that the GnRH pulse generator , which probably consists of a small population of GnRH neurons in the culture , does not involve GABA neurons to generate the pulsatile GnRH release , although it may be responsive to the inhibitory transmitter GABA .
12411736	7	GABA	1842,1846	GnRH	1768,1772	GABA	GnRH	MESH:D005680	25194(Tax:10116)	Chemical	Gene	responsive|nmod|START_ENTITY involve|advcl|responsive involve|xcomp|generate generate|dobj|release release|compound|END_ENTITY	In light of the in vivo studies performed previously , we suggest that the GnRH pulse generator , which probably consists of a small population of GnRH neurons in the culture , does not involve GABA neurons to generate the pulsatile GnRH release , although it may be responsive to the inhibitory transmitter GABA .
12654529	0	GABA	12,16	GnRH	98,102	GABA	GnRH	MESH:D005680	2796	Chemical	Gene	role|nmod|START_ENTITY receptors|nsubj|role receptors|nmod|systems systems|nmod|area area|nmod|control control|nmod|release release|compound|END_ENTITY	The role of GABA -LRB- A -RRB- receptors in the neural systems of the medial preoptic area in the control of GnRH release in ewes during follicular phase .
16781054	0	GABA	15,19	GnRH	51,55	GABA	GnRH	MESH:D005680	2796	Chemical	Gene	Development|nmod|START_ENTITY Development|acl|signaling signaling|nmod|neuron neuron|compound|END_ENTITY	Development of GABA and glutamate signaling at the GnRH neuron in relation to puberty .
17551263	0	GABA	0,4	GnRH	57,61	GABA	GnRH	MESH:D005680	2796	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|production production|nmod|neurons neurons|compound|END_ENTITY	GABA inhibition of cyclic_AMP production in immortalized GnRH neurons is mediated by calcineurin-dependent dephosphorylation of adenylyl_cyclase_9 .
18434046	0	GABA	11,15	GnRH	60,64	GABA	GnRH	MESH:D005680	2796	Chemical	Gene	receptor|compound|START_ENTITY Effects|nmod|receptor modulation|nsubj|Effects modulation|nmod|expression expression|nmod|gene gene|compound|END_ENTITY	Effects of GABA -LRB- A -RRB- receptor modulation on the expression of GnRH gene and GnRH_receptor -LRB- GnRH-R -RRB- gene in the hypothalamus and GnRH-R gene in the anterior pituitary gland of follicular-phase ewes .
20009027	0	GABA	19,23	GnRH	44,48	GABA	GnRH	MESH:D005680	14714(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY Lack|nmod|receptors alters|nsubj|Lack alters|dobj|physiology physiology|compound|END_ENTITY	Lack of functional GABA -LRB- B -RRB- receptors alters GnRH physiology and sexual dimorphic expression of GnRH and GAD-67 in the brain .
20009027	0	GABA	19,23	GnRH	95,99	GABA	GnRH	MESH:D005680	14714(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY Lack|nmod|receptors alters|nsubj|Lack alters|dobj|physiology physiology|nmod|END_ENTITY	Lack of functional GABA -LRB- B -RRB- receptors alters GnRH physiology and sexual dimorphic expression of GnRH and GAD-67 in the brain .
25506316	0	GABA	12,16	GnRH	38,42	GABA	GnRH	MESH:D005680	2796	Chemical	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	The role of GABA in the regulation of GnRH neurons .
3061570	0	GABA	33,37	GnRH	101,105	GABA	GnRH	MESH:D005680	25194(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|release release|nmod|gonadotropin-releasing_hormone gonadotropin-releasing_hormone|appos|END_ENTITY	Pre - and postsynaptic actions of GABA on the release of hypothalamic gonadotropin-releasing_hormone -LRB- GnRH -RRB- .
18091016	0	GABA	36,40	Growth_hormone	0,14	GABA	Growth hormone	MESH:D005680	2688	Chemical	Gene	ingestion|compound|START_ENTITY END_ENTITY|nmod|ingestion	Growth_hormone isoform responses to GABA ingestion at rest and after exercise .
25878279	0	GABA	18,22	KCC2	26,30	GABA	KCC2	MESH:D005680	57468	Chemical	Gene	START_ENTITY|nmod|signaling signaling|compound|END_ENTITY	Engagement of the GABA to KCC2 signaling pathway contributes to the analgesic effects of A3AR agonists in neuropathic_pain .
10698011	0	GABA	0,4	NGF	108,111	GABA	NGF	MESH:D005680	310738(Tax:10116)	Chemical	Gene	elevate|nsubj|START_ENTITY elevate|dobj|levels levels|nmod|nerve_growth_factor nerve_growth_factor|appos|END_ENTITY	GABA -LRB- B -RRB- receptor antagonists elevate both mRNA and protein levels of the neurotrophins nerve_growth_factor -LRB- NGF -RRB- and brain-derived_neurotrophic_factor -LRB- BDNF -RRB- but not neurotrophin-3 -LRB- NT-3 -RRB- in brain and spinal cord of rats .
17521572	0	GABA	45,49	Neuregulin-1	0,12	GABA	Neuregulin-1	MESH:D005680	3084	Chemical	Gene	release|compound|START_ENTITY enhances|dobj|release enhances|nsubj|END_ENTITY	Neuregulin-1 enhances depolarization-induced GABA release .
19244539	0	GABA	109,113	PKA	175,178	GABA	PKA	MESH:D005680	25636(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY release|nmod|END_ENTITY	At immature mossy-fiber-CA3 synapses , correlated presynaptic and postsynaptic activity persistently enhances GABA release and network excitability via BDNF and cAMP-dependent PKA .
10526339	0	GABA	31,35	PKCepsilon	87,97	GABA	PKCepsilon	MESH:D005680	18754(Tax:10090)	Chemical	Gene	Supersensitivity|nmod|START_ENTITY modulators|amod|Supersensitivity modulators|acl|lacking lacking|dobj|END_ENTITY	Supersensitivity to allosteric GABA -LRB- A -RRB- receptor modulators and alcohol in mice lacking PKCepsilon .
10757500	0	GABA	43,47	PKCepsilon	19,29	GABA	PKCepsilon	MESH:D005680	18754(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	Co-localization of PKCepsilon with various GABA -LRB- A -RRB- receptor subunits in the mouse limbic system .
19864580	0	GABA	39,43	Proopiomelanocortin	0,19	GABA	Proopiomelanocortin	MESH:D005680	18976(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Proopiomelanocortin expression in both GABA and glutamate neurons .
10679579	0	GABA	57,61	Protein_kinase	0,14	GABA	Protein kinase	MESH:D005680	380361(Tax:8355)	Chemical	Gene	modulation|nmod|START_ENTITY modulation|amod|END_ENTITY	Protein_kinase and phosphatase modulation of quail brain GABA -LRB- A -RRB- and non-NMDA receptors co-expressed in Xenopus oocytes .
10952672	0	GABA	98,102	RDL	113,116	GABA	RDL	MESH:D005680	39054(Tax:7227)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Single channel analysis of the blocking actions of BIDN and fipronil on a Drosophila_melanogaster GABA receptor -LRB- RDL -RRB- stably expressed in a Drosophila cell line .
15748149	0	GABA	91,95	RDL	87,90	GABA	RDL	MESH:D005680	6737389(Tax:7240)	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	Resistance to fipronil in Drosophila_simulans : influence of two point mutations in the RDL GABA receptor subunit .
17729251	0	GABA	102,106	RDL	164,167	GABA	RDL	MESH:D005680	39054(Tax:7227)	Chemical	Gene	localization|nmod|START_ENTITY receptors|nsubj|localization receptors|nmod|END_ENTITY	gamma-Aminobutyric_acid -LRB- GABA -RRB- signaling components in Drosophila : immunocytochemical localization of GABA -LRB- B -RRB- receptors in relation to the GABA -LRB- A -RRB- receptor subunit RDL and a vesicular_GABA_transporter .
17729251	0	GABA	25,29	RDL	164,167	GABA	RDL	MESH:D005680	39054(Tax:7227)	Chemical	Gene	gamma-Aminobutyric_acid|appos|START_ENTITY signaling|nsubj|gamma-Aminobutyric_acid signaling|parataxis|receptors receptors|nmod|END_ENTITY	gamma-Aminobutyric_acid -LRB- GABA -RRB- signaling components in Drosophila : immunocytochemical localization of GABA -LRB- B -RRB- receptors in relation to the GABA -LRB- A -RRB- receptor subunit RDL and a vesicular_GABA_transporter .
19230663	0	GABA	4,8	RDL	21,24	GABA	RDL	MESH:D005680	39054(Tax:7227)	Chemical	Gene	_|nsubj|START_ENTITY _|dobj|acts acts|compound|END_ENTITY	The GABA -LRB- A -RRB- _ receptor RDL acts in peptidergic PDF neurons to promote sleep in Drosophila .
8625394	0	GABA	72,76	RDL	95,98	GABA	RDL	MESH:D005680	39054(Tax:7227)	Chemical	Gene	subunit|compound|START_ENTITY antibody|nmod|subunit mapping|nmod|antibody END_ENTITY|nsubj|mapping	Immunocytochemical mapping of a C-terminus anti-peptide antibody to the GABA receptor subunit , RDL in the nervous system in Drosophila_melanogaster .
7898754	0	GABA	76,80	Rdl	91,94	GABA	Rdl	MESH:D005680	39054(Tax:7227)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Actions of agonists and convulsant antagonists on a Drosophila_melanogaster GABA receptor -LRB- Rdl -RRB- homo-oligomer expressed in Xenopus oocytes .
8601436	1	GABA	131,135	Rdl	127,130	GABA	Rdl	MESH:D005680	39054(Tax:7227)	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Promoters for efficient expression of Drosophila and mosquito Rdl GABA receptors in stably transformed mosquito cell lines .
9372130	0	GABA	31,35	Rdl	53,56	GABA	Rdl	MESH:D005680	39054(Tax:7227)	Chemical	Gene	subunit|compound|START_ENTITY Immunocytochemistry|nmod|subunit END_ENTITY|nsubj|Immunocytochemistry	Immunocytochemistry of a novel GABA receptor subunit Rdl in Drosophila_melanogaster .
9862468	0	GABA	23,27	Rdl	19,22	GABA	Rdl	MESH:D005680	6737389(Tax:7240)	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Duplication of the Rdl GABA receptor subunit gene in an insecticide-resistant aphid , Myzus persicae .
19077666	0	GABA	95,99	SLC6A1	88,94	GABA	SLC6A1	MESH:D005680	6529	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Twenty-one-base-pair insertion polymorphism creates an enhancer element and potentiates SLC6A1 GABA transporter promoter activity .
16571735	0	GABA	43,47	Somatostatin	0,12	GABA	Somatostatin	MESH:D005680	24797(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY inhibits|dobj|release inhibits|nsubj|END_ENTITY	Somatostatin presynaptically inhibits both GABA and glutamate release onto rat basal forebrain cholinergic neurons .
3216948	0	GABA	92,96	THPO	71,75	GABA	THPO	MESH:D005680	21832(Tax:10090)	Chemical	Gene	level|compound|START_ENTITY END_ENTITY|nmod|level	Amplification by glycine of the effect of the GABA transport inhibitor THPO on synaptosomal GABA level .
22726831	0	GABA	110,114	TREK1	101,106	GABA	TREK1	MESH:D005680	3776	Chemical	Gene	signaling|compound|START_ENTITY END_ENTITY|nmod|signaling	Optical control of endogenous proteins with a photoswitchable conditional subunit reveals a role for TREK1 in GABA -LRB- B -RRB- signaling .
6431450	0	GABA	169,173	TRH	196,199	GABA	TRH	MESH:D005680	7200	Chemical	Gene	action|compound|START_ENTITY action|nmod|END_ENTITY	Comparison of the CNS effects induced by TRH and bicuculline after microinjection into medial septum , substantia nigra and inferior colliculus : absence of support for a GABA antagonist action for TRH .
16990402	0	GABA	40,44	Thyrotropin-releasing_hormone	0,29	GABA	Thyrotropin-releasing hormone	MESH:D005680	25569(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|increases increases|amod|END_ENTITY	Thyrotropin-releasing_hormone increases GABA release in rat hippocampus .
21371425	0	GABA	0,4	UGA1	31,35	GABA	UGA1	MESH:D005680	852902(Tax:4932)	Chemical	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	GABA metabolism pathway genes , UGA1 and GAD1 , regulate replicative lifespan in Saccharomyces_cerevisiae .
12642390	0	GABA	73,77	UNC-49	66,72	GABA	UNC-49	MESH:D005680	176472(Tax:6239)	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Pharmacological characterization of the homomeric and heteromeric UNC-49 GABA receptors in C. _ elegans .
20180830	0	GABA	10,14	UNC-49	3,9	GABA	UNC-49	MESH:D005680	176472(Tax:6239)	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	An UNC-49 GABA receptor subunit from the parasitic nematode Haemonchus_contortus is associated with enhanced GABA sensitivity in nematode heteromeric channels .
20180830	0	GABA	109,113	UNC-49	3,9	GABA	UNC-49	MESH:D005680	176472(Tax:6239)	Chemical	Gene	sensitivity|compound|START_ENTITY associated|nmod|sensitivity associated|nsubjpass|subunit subunit|compound|END_ENTITY	An UNC-49 GABA receptor subunit from the parasitic nematode Haemonchus_contortus is associated with enhanced GABA sensitivity in nematode heteromeric channels .
9250617	0	GABA	7,11	VDCC	46,50	GABA	VDCC	MESH:D005680	56827(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY mediated|nsubjpass|release mediated|nmod|END_ENTITY	Evoked GABA release is not mediated by N-type VDCC in the frontal cortex of awake rats : effects of neomycin .
12850545	1	GABA	401,405	VGAT	441,445	GABA	VGAT	MESH:D005680	140679	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Changes in vesicular gamma-aminobutyric_acid -LRB- GABA -RRB- transporter -LRB- VGAT -RRB- expression in the gerbil hippocampus after treatment with baclofen -LRB- GABA -LRB- B -RRB- receptor agonist -RRB- or phaclofen -LRB- GABA -LRB- B -RRB- receptor antagonist -RRB- were investigated to identify the GABA -LRB- B -RRB- receptor-mediated regulation of VGAT expression .
10716236	0	GABA	48,52	adenosine_A2A_receptor	10,32	GABA	adenosine A2A receptor	MESH:D005680	25369(Tax:10116)	Chemical	Gene	stimulation|nmod|START_ENTITY stimulation|amod|END_ENTITY	Effect of adenosine_A2A_receptor stimulation on GABA release from the striatum of young and aged rats in vivo .
7760061	0	GABA	23,27	adenosine_A2a_receptor	43,65	GABA	adenosine A2a receptor	MESH:D005680	135	Chemical	Gene	release|compound|START_ENTITY release|nmod|END_ENTITY	Inhibition of striatal GABA release by the adenosine_A2a_receptor is not mediated by increases in cyclic_AMP .
15990198	0	GABA	39,43	alpha-MSH	18,27	GABA	alpha-MSH	MESH:D005680	5443	Chemical	Gene	release|nmod|START_ENTITY release|amod|END_ENTITY	The regulation of alpha-MSH release by GABA is mediated by a chloride-dependent -LSB- Ca2 + -RSB- c increase in frog melanotrope cells .
2552350	0	GABA	82,86	alpha-melanocyte-stimulating_hormone	105,141	GABA	alpha-melanocyte-stimulating hormone	MESH:D005680	5443	Chemical	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	Central-type benzodiazepines and the octadecaneuropeptide modulate the effects of GABA on the release of alpha-melanocyte-stimulating_hormone from frog neurointermediate lobe in vitro .
9754930	0	GABA	48,52	alpha1	30,36	GABA	alpha1	MESH:D005680	146	Chemical	Gene	receptors|compound|START_ENTITY subunit|nmod|receptors subunit|amod|END_ENTITY	Amino_acid residue 200 on the alpha1 subunit of GABA -LRB- A -RRB- receptors affects the interaction with selected benzodiazepine binding site ligands .
11290383	0	GABA	71,75	alpha1/gamma2	98,111	GABA	alpha1/gamma2	MESH:D005680	146;7453	Chemical	Gene	subunits|compound|START_ENTITY subunits|appos|END_ENTITY	Molecular determinants of desensitization and assembly of the chimeric GABA -LRB- A -RRB- receptor subunits -LRB- alpha1/gamma2 -RRB- and -LRB- gamma2/alpha1 -RRB- in combinations with beta2 and gamma2 .
10078620	0	GABA	0,4	alpha4	17,23	GABA	alpha4	MESH:D005680	18518(Tax:10090)	Chemical	Gene	receptor|nsubj|START_ENTITY receptor|dobj|subunit subunit|amod|END_ENTITY	GABA -LRB- A -RRB- receptor alpha4 subunit in DBA/2J and C57BL/6J mice .
17081691	0	GABA	65,69	alpha4	43,49	GABA	alpha4	MESH:D005680	3476	Chemical	Gene	receptor|compound|START_ENTITY subunit|nmod|receptor subunit|amod|END_ENTITY	Steroid requirements for regulation of the alpha4 subunit of the GABA -LRB- A -RRB- receptor in an in vitro model .
19285093	0	GABA	47,51	alpha4	25,31	GABA	alpha4	MESH:D005680	3476	Chemical	Gene	receptor|compound|START_ENTITY subunit|nmod|receptor subunit|amod|END_ENTITY	Expression levels of the alpha4 subunit of the GABA -LRB- A -RRB- receptor in differentiated neuroblastoma cells are correlated with GABA-gated current .
8606368	0	GABA	40,44	alpha_1	25,32	GABA	alpha 1	MESH:D005680	146	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Rapid desensitization of alpha_1 beta 1 GABA A receptors expressed in Sf9 cells under optimized conditions .
3768735	0	GABA	116,120	angiotensin_II	76,90	GABA	angiotensin II	MESH:D005680	24179(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY injected|nsubj|effects elicited|parataxis|injected elicited|nmod|administration administration|nmod|END_ENTITY	Cardiovascular and drinking responses elicited by central administration of angiotensin_II : differential effects of GABA injected into the ventral tegmental area and spiperone injected into the nucleus accumbens .
6514131	0	GABA	0,4	angiotensin_II	75,89	GABA	angiotensin II	MESH:D005680	24179(Tax:10116)	Chemical	Gene	agonists|compound|START_ENTITY inhibit|nsubj|agonists inhibit|dobj|effects effects|nmod|END_ENTITY	GABA agonists inhibit the vasopressin-dependent pressor effects of central angiotensin_II .
6871675	0	GABA	0,4	angiotensin_II	27,41	GABA	angiotensin II	MESH:D005680	24179(Tax:10116)	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	GABA inhibition of central angiotensin_II and hypertonic CSF pressor responses .
8157090	0	GABA	154,158	angiotensin_II	11,25	GABA	angiotensin II	MESH:D005680	24179(Tax:10116)	Chemical	Gene	gamma-aminobutyric_acid|appos|START_ENTITY involvement|nmod|gamma-aminobutyric_acid area|dep|involvement exerted|nmod|area exerted|nsubjpass|Effects Effects|nmod|END_ENTITY	Effects of angiotensin_II and atrial_natriuretic_peptide on LH release are exerted in the preoptic area : possible involvement of gamma-aminobutyric_acid -LRB- GABA -RRB- .
10501199	0	GABA	75,79	beta3	92,97	GABA	beta3	MESH:D005680	14402(Tax:10090)	Chemical	Gene	mice|amod|START_ENTITY mice|nummod|END_ENTITY	Increased acute cocaine sensitivity and decreased cocaine sensitization in GABA -LRB- A -RRB- receptor beta3 subunit knockout mice .
10646536	0	GABA	110,114	beta3	85,90	GABA	beta3	MESH:D005680	14402(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Identification of an amino_acid defining the distinct properties of murine beta1 and beta3 subunit-containing GABA -LRB- A -RRB- receptors .
10670447	0	GABA	118,122	beta3	97,102	GABA	beta3	MESH:D005680	14402(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY subunit|nmod|receptor subunit|amod|END_ENTITY	Sensory thresholds and the antinociceptive effects of GABA receptor agonists in mice lacking the beta3 subunit of the GABA -LRB- A -RRB- receptor .
10728882	0	GABA	60,64	beta3	31,36	GABA	beta3	MESH:D005680	1934	Chemical	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	The influence of an endogenous beta3 subunit on recombinant GABA -LRB- A -RRB- receptor assembly and pharmacology in WSS-1 cells and transiently transfected HEK293 cells .
12183328	0	GABA	66,70	beta3	83,88	GABA	beta3	MESH:D005680	14402(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|subunit subunit|amod|END_ENTITY	An N-terminal histidine regulates Zn -LRB- 2 + -RRB- inhibition on the murine GABA -LRB- A -RRB- receptor beta3 subunit .
12485409	0	GABA	48,52	beta3	65,70	GABA	beta3	MESH:D005680	1934	Chemical	Gene	sequence|nmod|START_ENTITY Identification|nmod|sequence receptor|nsubj|Identification receptor|dobj|subunits subunits|amod|END_ENTITY	Identification of an amino_acid sequence within GABA -LRB- A -RRB- receptor beta3 subunits that is important for receptor assembly .
12522165	0	GABA	0,4	beta3	17,22	GABA	beta3	MESH:D005680	14402(Tax:10090)	Chemical	Gene	receptor|nsubj|START_ENTITY receptor|ccomp|decreases decreases|nsubj|deletion deletion|amod|END_ENTITY	GABA -LRB- A -RRB- receptor beta3 subunit deletion decreases alpha2/3 subunits and IPSC duration .
16393151	0	GABA	67,71	beta3	81,86	GABA	beta3	MESH:D005680	14402(Tax:10090)	Chemical	Gene	functioning|nmod|START_ENTITY evidence|nmod|functioning receptor|nsubj|evidence receptor|dobj|mice mice|amod|END_ENTITY	Pharmacologic evidence for abnormal thalamocortical functioning in GABA receptor beta3 subunit-deficient mice , a model of Angelman_syndrome .
9464918	0	GABA	77,81	beta3	71,76	GABA	beta3	MESH:D005680	14402(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Pharmacological and physiological characterization of murine homomeric beta3 GABA -LRB- A -RRB- receptors .
9545084	0	GABA	73,77	beta_3	97,103	GABA	beta 3	MESH:D005680	1934	Chemical	Gene	subunits|amod|START_ENTITY subunits|amod|END_ENTITY	Granule cells of the internal granule layer have increased expression of GABA -LRB- A -RRB- _ receptor_beta_2 / beta_3 subunits .
16407567	0	GABA	43,47	brain_natriuretic_peptide	14,39	GABA	brain natriuretic peptide	MESH:D005680	25105(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY END_ENTITY|nmod|receptors	Modulation by brain_natriuretic_peptide of GABA receptors on rat retinal ON-type bipolar cells .
15451404	0	GABA	68,72	calbindin-D-28k	34,49	GABA	calbindin-D-28k	MESH:D005680	12307(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Altered hippocampal expression of calbindin-D-28k and calretinin in GABA -LRB- B -LRB- 1 -RRB- -RRB- - deficient mice .
21236282	0	GABA	0,4	corticotropin_releasing_hormone	15,46	GABA	corticotropin releasing hormone	MESH:D005680	12918(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|levels levels|amod|END_ENTITY	GABA regulates corticotropin_releasing_hormone levels in the paraventricular nucleus of the hypothalamus in newborn mice .
20938761	0	GABA	62,66	fos	44,47	GABA	fos	MESH:D005680	314322(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Detection of conspecific pheromones elicits fos expression in GABA and calcium-binding cells of the rat vomeronasal system-medial extended amygdala .
20233604	0	GABA	58,62	gamma2	75,81	GABA	gamma2	MESH:D005680	14406(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|subunit subunit|amod|END_ENTITY	Fyn kinase contributes to tyrosine phosphorylation of the GABA -LRB- A -RRB- receptor gamma2 subunit .
10727622	0	GABA	20,24	gb2	45,48	GABA	gb2	MESH:D005680	83633(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY Distribution|nmod|receptor subunit|nsubj|Distribution subunit|dobj|END_ENTITY	Distribution of the GABA -LRB- B -RRB- receptor subunit gb2 in rat CNS .
17179652	0	GABA	15,19	gonadotropin-releasing_hormone	33,63	GABA	gonadotropin-releasing hormone	MESH:D005680	25194(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|neurons neurons|amod|END_ENTITY	The Effects of GABA on embryonic gonadotropin-releasing_hormone neurons in rat hypothalamic primary culture .
12767456	1	GABA	57,61	insulin	82,89	GABA	insulin	MESH:D005680	3630	Chemical	Gene	TNF-alpha|dep|START_ENTITY TNF-alpha|dep|END_ENTITY	A discussion on the role of ras , GABA , acetylcholine , NO , insulin , TNF-alpha , and long-chain polyunsaturated_fatty_acids in memory formation and consolidation .
21353350	0	GABA	59,63	mGAT3	43,48	GABA	mGAT3	MESH:D005680	243616(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY uptake|nummod|END_ENTITY	Development of imidazole_alkanoic_acids as mGAT3 selective GABA uptake inhibitors .
12364505	0	GABA	31,35	mGluR5	14,20	GABA	mGluR5	MESH:D005680	14805(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Activation of mGluR5 modulates GABA -LRB- A -RRB- _ receptor function in retinal amacrine cells .
18155073	0	GABA	101,105	mGluR7	39,45	GABA	mGluR7	MESH:D005680	14807(Tax:10090)	Chemical	Gene	agonist|amod|START_ENTITY agonist|compound|END_ENTITY	The metabotropic glutamate receptor 7 -LRB- mGluR7 -RRB- allosteric agonist AMN082 modulates nucleus accumbens GABA and glutamate , but not dopamine , in rats .
17962336	6	GABA	858,862	mice	880,884	GABA	TAUT	MESH:D005680	21366(Tax:10090)	Chemical	Gene	level|compound|START_ENTITY level|nmod|END_ENTITY	The striatal GABA level in TAUT KO mice was unchanged .
26471792	0	GABA	0,4	mucin-1	27,34	GABA	mucin-1	MESH:D005680	397382(Tax:9823)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	GABA selectively increases mucin-1 expression in isolated pig jejunum .
9585130	0	GABA	50,54	neurokinin-1_receptor	14,35	GABA	neurokinin-1 receptor	MESH:D005680	24807(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY expression|nmod|receptor expression|amod|END_ENTITY	Regulation of neurokinin-1_receptor expression by GABA -LRB- B -RRB- receptor agonists .
7936192	0	GABA	16,20	neurotensin	32,43	GABA	neurotensin	MESH:D005680	299757(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY release|nmod|END_ENTITY	Facilitation of GABA release by neurotensin is associated with a reduction of dopamine release in rat nucleus accumbens .
481679	2	GABA	69,73	ornithine_decarboxylase	77,100	GABA	ornithine decarboxylase	MESH:D005680	24609(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|amod|END_ENTITY	Effect of GABA on ornithine_decarboxylase and putrescine levels in cell culture .
7091360	0	GABA	10,14	ornithine_decarboxylase	36,59	GABA	ornithine decarboxylase	MESH:D005680	24609(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|metabolism metabolism|amod|END_ENTITY	Effect of GABA and isogabaculine on ornithine_decarboxylase and putrescine metabolism .
11867528	0	GABA	64,68	p130	56,60	GABA	p130	MESH:D005680	70769(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	Role of the PLC-related , catalytically inactive protein p130 in GABA -LRB- A -RRB- receptor function .
6261177	0	GABA	0,4	prolactin	41,50	GABA	prolactin	MESH:D005680	24683(Tax:10116)	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|release release|nmod|END_ENTITY	GABA and muscimol inhibit the release of prolactin from dispersed rat anterior pituitary cells .
14973227	0	GABA	0,4	proopiomelanocortin	18,37	GABA	proopiomelanocortin	MESH:D005680	5443	Chemical	Gene	release|nsubj|START_ENTITY release|nmod|neurons neurons|compound|END_ENTITY	GABA release from proopiomelanocortin neurons .
19912829	0	GABA	18,22	proopiomelanocortin	67,86	GABA	proopiomelanocortin	MESH:D005680	24664(Tax:10116)	Chemical	Gene	Activation|nmod|START_ENTITY inhibits|nsubj|Activation inhibits|dobj|expression expression|compound|END_ENTITY	Activation of the GABA -LRB- A -RRB- - benzodiazepine receptor complex inhibits proopiomelanocortin gene expression in the rat arcuate nucleus .
22442070	0	GABA	14,18	proopiomelanocortin	46,65	GABA	proopiomelanocortin	MESH:D005680	18976(Tax:10090)	Chemical	Gene	Regulation|nmod|START_ENTITY release|nsubj|Regulation release|nmod|terminals terminals|amod|END_ENTITY	Regulation of GABA and glutamate release from proopiomelanocortin neuron terminals in intact hypothalamic networks .
3737446	0	GABA	0,4	proopiomelanocortin	53,72	GABA	proopiomelanocortin	MESH:D005680	24664(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|pituitary pituitary|amod|END_ENTITY	GABA differentially regulates the gene expression of proopiomelanocortin in rat intermediate and anterior pituitary .
18945815	0	GABA	76,80	protein_kinase_A	12,28	GABA	protein kinase A	MESH:D005680	25636(Tax:10116)	Chemical	Gene	increase|nmod|START_ENTITY END_ENTITY|nmod|increase	The role of protein_kinase_A in the ethanol-induced increase in spontaneous GABA release onto cerebellar Purkinje neurons .
3937548	0	GABA	50,54	thyrotropin_releasing_hormone	11,40	GABA	thyrotropin releasing hormone	MESH:D005680	22044(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY Effect|nmod|metabolism Effect|nmod|END_ENTITY	-LSB- Effect of thyrotropin_releasing_hormone -LRB- TRH -RRB- on GABA -LRB- gamma_aminobutyric_acid -RRB- metabolism in mouse and rat brains : as to the activities of GAD -LRB- glutamic_acid decarboxylase -RRB- , GABA-T -LRB- GABA-transaminase -RRB- and GABA re-uptake -RSB- .
1981253	0	GABA	0,4	tyrosine_hydroxylase	28,48	GABA	tyrosine hydroxylase	MESH:D005680	25085(Tax:10116)	Chemical	Gene	modulation|compound|START_ENTITY modulation|nmod|expression expression|amod|END_ENTITY	GABA receptor modulation of tyrosine_hydroxylase gene expression in the rat adrenal gland .
10414952	0	GABA	96,100	unc-47	89,95	GABA	unc-47	MESH:D005680	176431(Tax:6239)	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	Coordinated transcriptional regulation of the unc-25 glutamic_acid decarboxylase and the unc-47 GABA vesicular transporter by the Caenorhabditis_elegans UNC-30 homeodomain protein .
22727682	0	GABA	64,68	unc-49	36,42	GABA	unc-49	MESH:D005680	176472(Tax:6239)	Chemical	Gene	y-aminobutyric_acid|appos|START_ENTITY y-aminobutyric_acid|amod|END_ENTITY	Decreased_emodepside_sensitivity in unc-49 y-aminobutyric_acid -LRB- GABA -RRB- - receptor-deficient Caenorhabditis_elegans .
24694609	0	GANT61	4,10	GLI	14,17	GANT61	GLI	MESH:C551027	2735	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	The GANT61 , a GLI inhibitor , induces caspase-independent apoptosis of SK-N-LO cells .
8773564	13	GBR12909	1661,1669	DAT	1695,1698	GBR12909	DAT	MESH:C043425	24898(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	GBR12909 , a specific inhibitor of DAT , blocked the -LSB- 3H -RSB- - dopamine at a concentration of 10 -LRB- -7 -RRB- M .
15140185	0	GBR12909	105,113	dopamine_transporter	36,56	GBR12909	dopamine transporter	MESH:C043425	6531	Chemical	Gene	interaction|nmod|START_ENTITY mode|nmod|interaction opposed|nsubj|mode reveals|xcomp|opposed reveals|nsubj|Mutation Mutation|nmod|Trp84 Trp84|nmod|END_ENTITY	Mutation of Trp84 and Asp313 of the dopamine_transporter reveals similar mode of binding interaction for GBR12909 and benztropine as opposed to cocaine .
25612063	0	GBR12909	76,84	dopamine_transporter	44,64	GBR12909	dopamine transporter	MESH:C043425	24898(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Pharmacological MRI response to a selective dopamine_transporter inhibitor , GBR12909 , in awake and anesthetized rats .
8097720	0	GBR_12909	60,69	dopamine_D1_and_D2_receptors	13,41	GBR 12909	dopamine D1 and D2 receptors	MESH:C043425	13488;13489	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nmod|effects	Mediation of dopamine_D1_and_D2_receptors in the effects of GBR_12909 on latent learning and locomotor activity in mice .
3022176	0	GB_52	29,34	enkephalinase	4,17	GB 52	enkephalinase	MESH:C050512	4311	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	The enkephalinase inhibitor , GB_52 , does not affect nociceptive flexion reflexes nor pain sensation in humans .
23287563	0	GDC-0068	29,37	Akt	20,23	GDC-0068	Akt	null	207	Chemical	Gene	Targeting|nmod|START_ENTITY Targeting|dobj|END_ENTITY	Targeting activated Akt with GDC-0068 , a novel selective Akt inhibitor that is efficacious in multiple_tumor models .
19509167	0	GDC-0941	85,93	PI3K	94,98	GDC-0941	PI3K	MESH:C532162	5293	Chemical	Gene	combinations|nmod|START_ENTITY cells|nmod|combinations growth|nmod|cells Suppression|nmod|growth END_ENTITY|nsubj|Suppression	Suppression of HER2/HER3-mediated growth of breast_cancer cells with combinations of GDC-0941 PI3K inhibitor , trastuzumab , and pertuzumab .
21838594	0	GDC-0941	57,65	PI3K	42,46	GDC-0941	PI3K	MESH:C532162	5293	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|pharmacokinetics pharmacokinetics|nmod|END_ENTITY	Preclinical pharmacokinetics of the novel PI3K inhibitor GDC-0941 and prediction of its pharmacokinetics and efficacy in human .
21994956	0	GDC-0941	0,8	PI3K	116,120	GDC-0941	PI3K	MESH:C532162	5295	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|kinase kinase|appos|END_ENTITY	GDC-0941 inhibits metastatic characteristics of thyroid_carcinomas by targeting both the phosphoinositide-3 kinase -LRB- PI3K -RRB- and hypoxia-inducible_factor-1a -LRB- HIF-1a -RRB- pathways .
22287727	0	GDC-0941	61,69	PI3K	45,49	GDC-0941	PI3K	MESH:C532162	18708(Tax:10090)	Chemical	Gene	multi-treatments|appos|START_ENTITY multi-treatments|amod|efficacy efficacy|nmod|END_ENTITY	Quantitative MRI establishes the efficacy of PI3K inhibitor -LRB- GDC-0941 -RRB- multi-treatments in PTEN-deficient_mice_lymphoma .
23231951	0	GDC-0941	50,58	PI3K	34,38	GDC-0941	PI3K	MESH:C532162	5293	Chemical	Gene	Inhibitor|appos|START_ENTITY Inhibitor|compound|END_ENTITY	A potent combination of the novel PI3K Inhibitor , GDC-0941 , with imatinib in gastrointestinal_stromal_tumor xenografts : long-lasting responses after treatment withdrawal .
25370471	0	GDC-0941	44,52	PI3K	107,111	GDC-0941	PI3K	MESH:C532162	5290	Chemical	Gene	Pictilisib|appos|START_ENTITY Study|nmod|Pictilisib Study|appos|Pan-Class Pan-Class|dep|Inhibitor Inhibitor|appos|END_ENTITY	First-in-Human Phase I Study of Pictilisib -LRB- GDC-0941 -RRB- , a Potent Pan-Class I Phosphatidylinositol-3-Kinase -LRB- PI3K -RRB- Inhibitor , in Patients with Advanced_Solid_Tumors .
24601221	0	GDC-0941	46,54	PIK3CA	77,83	GDC-0941	PIK3CA	MESH:C532162	5290	Chemical	Gene	efficacy|nmod|START_ENTITY efficacy|nmod|mutation mutation|compound|END_ENTITY	More antitumor efficacy of the PI3K inhibitor GDC-0941 in breast_cancer with PIK3CA mutation or HER2 amplification status in vitro .
14583477	0	GDP	16,19	BCAR3	7,12	GDP	BCAR3	MESH:D006153	8412	Chemical	Gene	factor|compound|START_ENTITY END_ENTITY|appos|factor	AND-34 / BCAR3 , a GDP exchange factor whose overexpression confers antiestrogen resistance , activates Rac , PAK1 , and the cyclin_D1 promoter .
1325662	0	GDP	50,53	Epidermal_growth_factor	0,23	GDP	Epidermal growth factor	MESH:D006153	1950	Chemical	Gene	release|nmod|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Epidermal_growth_factor stimulates the release of GDP induced by isoproterenol from isolated liver membrane .
8072545	0	GDP	6,9	Gs_alpha	23,31	GDP	Gs alpha	MESH:D006153	2778	Chemical	Gene	release|nsubj|START_ENTITY release|nmod|END_ENTITY	Rapid GDP release from Gs_alpha in patients with gain and loss of endocrine function .
20713063	0	GDP	124,127	IF2	101,104	GDP	IF2	MESH:D006153	9669	Chemical	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	Thermodynamic characterization of ppGpp binding to EF-G or IF2 and of initiator tRNA binding to free IF2 in the presence of GDP , GTP , or ppGpp .
8263034	0	GDP	19,22	Insulin	0,7	GDP	Insulin	MESH:D006153	3630	Chemical	Gene	release|compound|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Insulin stimulates GDP release from G proteins in the rat and human liver plasma membranes .
15196914	0	GDP	39,42	Rab9	21,25	GDP	Rab9	MESH:D006153	9367	Chemical	Gene	complexed|nmod|START_ENTITY END_ENTITY|acl|complexed	Crystal structure of Rab9 complexed to GDP reveals a dimer with an active conformation of switch II .
24352424	0	GDP	43,46	eIF2B	0,5	GDP	eIF2B	MESH:D006153	8890	Chemical	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	eIF2B promotes eIF5 dissociation from eIF2 * GDP to facilitate guanine_nucleotide exchange for translation initiation .
11574461	0	GDP	90,93	elongation_factor_1alpha	49,73	GDP	elongation factor 1alpha	MESH:D006153	24866820	Chemical	Gene	complex|nmod|START_ENTITY END_ENTITY|nmod|complex	The crystal structure of Sulfolobus_solfataricus elongation_factor_1alpha in complex with GDP reveals novel features in nucleotide binding and exchange .
2508560	0	GDP	33,36	elongation_factor_Tu	65,85	GDP	elongation factor Tu	MESH:D006153	1915	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Site-directed mutagenesis of the GDP binding domain of bacterial elongation_factor_Tu .
3651421	0	GDP	69,72	elongation_factor_Tu	26,46	GDP	elongation factor Tu	MESH:D006153	1915	Chemical	Gene	Ts|compound|START_ENTITY fluorescence|nmod|Ts fluorescence|nmod|END_ENTITY	Intrinsic fluorescence of elongation_factor_Tu in its complexes with GDP and elongation factor Ts .
1637501	2	GDP	134,137	p21	107,110	GDP	p21	MESH:D006153	644914	Chemical	Gene	complexed|nmod|START_ENTITY complexed|nsubj|structure structure|nmod|protein protein|amod|END_ENTITY	An energy-refined structure for the normal p21 protein complexed with GDP .
2164357	0	GDP	98,101	p21	110,113	GDP	p21	MESH:D006153	644914	Chemical	Gene	proteins|compound|START_ENTITY proteins|compound|END_ENTITY	Electron paramagnetic resonance measurements of the hydration of Mn -LRB- II -RRB- in ternary complexes with GDP and ras p21 proteins .
8142406	0	GDP	147,150	p21	39,42	GDP	p21	MESH:D006153	644914	Chemical	Gene	forms|compound|START_ENTITY comparisons|nmod|forms Characterization|dep|comparisons Characterization|nmod|site site|nmod|ras ras|amod|END_ENTITY	Characterization of the active site of p21 ras by electron spin-echo envelope modulation spectroscopy with selective labeling : comparisons between GDP and GTP forms .
8393791	0	GDP	76,79	p21	29,32	GDP	p21	MESH:D006153	644914	Chemical	Gene	labeling|nmod|START_ENTITY labeling|nmod|elements elements|amod|END_ENTITY	Affinity labeling of c-H-ras p21 consensus elements with periodate-oxidized GDP and GTP .
8593186	0	GDP	85,88	p21	114,117	GDP	p21	MESH:D006153	644914	Chemical	Gene	bound|nmod|START_ENTITY structures|dep|bound Comparison|nmod|structures Comparison|nmod|protein protein|amod|END_ENTITY	Comparison of the computed three-dimensional structures of oncogenic forms -LRB- bound to GDP -RRB- of the ras-gene-encoded p21 protein with the structure of the normal -LRB- non-transforming -RRB- wild-type protein .
8810926	0	GDP	110,113	p21	131,134	GDP	p21	MESH:D006153	644914	Chemical	Gene	forms|compound|START_ENTITY forms|nmod|ras ras|amod|END_ENTITY	High frequency -LRB- 139.5 GHz -RRB- electron paramagnetic resonance characterization of Mn -LRB- II -RRB- - H2 -LRB- 17 -RRB- O interactions in GDP and GTP forms of p21 ras .
18440775	3	GF109203X	732,741	PKC	717,720	GF109203X	PKD	MESH:C070515	5587	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	The PKC inhibitor , GF109203X , partially reduced VEGF-induced HSP27 serine 82 phosphorylation , and SB203580 plus GF109203X abolished phosphorylation .
9405068	9	GF109203X	1494,1503	PKC	1479,1482	GF109203X	NMB	MESH:C070515	499194(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Pretreatment with the selective PKC inhibitor , GF109203X , inhibited TPA-induced p125 -LRB- FAK -RRB- tyrosine phosphorylation , but it had no effect on the NMB stimulation .
10573204	0	GF120918	61,69	P-glycoprotein	98,112	GF120918	P-glycoprotein	MESH:C083501	5243	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Clinical pharmacokinetics of doxorubicin in combination with GF120918 , a potent inhibitor of MDR1 P-glycoprotein .
15056727	0	GF120918	94,102	P-glycoprotein	46,60	GF120918	P-glycoprotein	MESH:C083501	287115(Tax:10116)	Chemical	Gene	salt|nmod|START_ENTITY properties|dep|salt properties|nmod|GF120918A GF120918A|amod|END_ENTITY	Preclinical pharmacokinetic properties of the P-glycoprotein inhibitor GF120918A -LRB- HCl salt of GF120918 , 9,10-dihydro-5-methoxy-9-oxo-N - -LSB- 4 - -LSB- 2 - -LRB- 1,2,3,4-tetrahydro-6 ,7 - dimethoxy-2-isoquinolinyl -RRB- ethyl -RSB- phenyl -RSB- -4 - acridine-carboxamide -RRB- in the mouse , rat , dog , and monkey .
21816979	0	GFT505	42,48	PPAR_a	24,30	GFT505	PPAR a	null	5465	Chemical	Gene	Effects|dep|START_ENTITY Effects|nmod|END_ENTITY	Effects of the new dual PPAR_a / agonist GFT505 on lipid and glucose homeostasis in abdominally_obese patients with combined_dyslipidemia or impaired_glucose_metabolism .
20195240	0	GG-52	31,36	NF-kappaB	46,55	GG-52	NF-kappaB	null	18033(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|signaling signaling|compound|END_ENTITY	Novel guggulsterone derivative GG-52 inhibits NF-kappaB signaling in intestinal epithelial cells and attenuates acute murine colitis .
8548018	0	GG167	109,114	neuraminidase	84,97	GG167	neuraminidase	MESH:D053243	4758	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Automated high-performance liquid chromatographic method for the determination of a neuraminidase inhibitor -LRB- GG167 -RRB- in human serum by pre-column fluorescence derivatisation using benzoin .
9819384	0	GGTI-298	75,83	p21	0,3	GGTI-298	p21	MESH:C102521	1026	Chemical	Gene	upregulated|nmod|START_ENTITY upregulated|nsubjpass|END_ENTITY	p21 -LRB- WAF1/CIP1 -RRB- is upregulated by the geranylgeranyltransferase I inhibitor GGTI-298 through a transforming_growth_factor_beta - and Sp1-responsive element : involvement of the small GTPase rhoA .
1592893	0	GH-releasing_hormone	107,127	GH	81,83	GH-releasing hormone	GH	null	2688	Chemical	Gene	response|nmod|START_ENTITY response|appos|END_ENTITY	Sleep , awakenings , and insulin-like_growth_factor-I modulate the growth_hormone -LRB- GH -RRB- secretory response to GH-releasing_hormone .
1592893	0	GH-releasing_hormone	107,127	growth_hormone	65,79	GH-releasing hormone	growth hormone	null	2688	Chemical	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Sleep , awakenings , and insulin-like_growth_factor-I modulate the growth_hormone -LRB- GH -RRB- secretory response to GH-releasing_hormone .
15246968	0	GI181771X	29,38	CCK-1	15,20	GI181771X	CCK-1	MESH:C488719	56477	Chemical	Gene	agonist|dobj|START_ENTITY agonist|nsubj|Effect Effect|nmod|END_ENTITY	Effect of oral CCK-1 agonist GI181771X on fasting and postprandial gastric functions in healthy volunteers .
12187934	0	GI262570X	20,29	PPAR-gamma	31,41	GI262570X	PPAR-gamma	null	25664(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Vascular effects of GI262570X -LRB- PPAR-gamma agonist -RRB- in the brown adipose tissue of Han Wistar_rats : a review of 1-month , 13-week , 27-week and 2-year oral toxicity studies .
10498596	0	GI5402	45,51	tumor_necrosis_factor-alpha	56,83	GI5402	tumor necrosis factor-alpha	null	7124	Chemical	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The effect of a metalloproteinase inhibitor -LRB- GI5402 -RRB- on tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- and TNF-alpha receptors during human endotoxemia .
23604466	0	GK13	47,51	transglutaminase_2	57,75	GK13	transglutaminase 2	MESH:C056415	100379228(Tax:10141)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|inhibitor inhibitor|amod|END_ENTITY	Anti-cancer effect of a quinoxaline derivative GK13 as a transglutaminase_2 inhibitor .
23848532	0	GKT136901	21,30	NOX1/4	4,10	GKT136901	NOX1/4	MESH:C554850	27035;50507	Chemical	Gene	START_ENTITY|nsubj|inhibitor inhibitor|compound|END_ENTITY	The NOX1/4 inhibitor GKT136901 as selective and direct scavenger of peroxynitrite .
12593853	0	GL331	0,5	HIF-1alpha	15,25	GL331	HIF-1alpha	MESH:C121391	3091	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	GL331 inhibits HIF-1alpha expression in a lung_cancer model .
22950522	0	GLPG0259	46,54	MAPKAPK5	119,127	GLPG0259	MAPKAPK5	null	8550	Chemical	Gene	Pharmacokinetics|nmod|START_ENTITY Pharmacokinetics|appos|inhibitor inhibitor|appos|END_ENTITY	Pharmacokinetics , safety , and tolerability of GLPG0259 , a mitogen-activated_protein_kinase-activated_protein_kinase_5 -LRB- MAPKAPK5 -RRB- inhibitor , given as single and multiple doses to healthy male subjects .
22950522	0	GLPG0259	46,54	mitogen-activated_protein_kinase-activated_protein_kinase_5	58,117	GLPG0259	mitogen-activated protein kinase-activated protein kinase 5	null	8550	Chemical	Gene	Pharmacokinetics|nmod|START_ENTITY Pharmacokinetics|appos|inhibitor inhibitor|amod|END_ENTITY	Pharmacokinetics , safety , and tolerability of GLPG0259 , a mitogen-activated_protein_kinase-activated_protein_kinase_5 -LRB- MAPKAPK5 -RRB- inhibitor , given as single and multiple doses to healthy male subjects .
23523664	0	GLPG0492	0,8	androgen_receptor	28,45	GLPG0492	androgen receptor	MESH:C577110	11835(Tax:10090)	Chemical	Gene	START_ENTITY|appos|modulator modulator|compound|END_ENTITY	GLPG0492 , a novel selective androgen_receptor modulator , improves muscle performance in the exercised-mdx mouse model of muscular_dystrophy .
24006460	0	GLPG0634	32,40	JAK1	67,71	GLPG0634	JAK1	null	3716	Chemical	Gene	characterization|nmod|START_ENTITY characterization|appos|inhibitor inhibitor|nmod|END_ENTITY	Preclinical characterization of GLPG0634 , a selective inhibitor of JAK1 , for the treatment of inflammatory diseases .
22708523	0	GLUCOSE	42,49	AMP-ACTIVATED_PROTEIN_KINASE	0,28	GLUCOSE	AMP-ACTIVATED PROTEIN KINASE	MESH:D005947	78975(Tax:10116)	Chemical	Gene	UPTAKE|compound|START_ENTITY END_ENTITY|dobj|UPTAKE	AMP-ACTIVATED_PROTEIN_KINASE UP REGULATES GLUCOSE UPTAKE IN THYROID PCCL3 CELLS INDEPENDENT OF THYROTROPIN .
25505362	0	GLUCOSE	22,29	INSULIN	35,42	GLUCOSE	INSULIN	MESH:D005947	3630	Chemical	Gene	LEVELS|advmod|START_ENTITY LEVELS|nsubj|END_ENTITY	FASTING PLASMA LIPID , GLUCOSE , AND INSULIN LEVELS IN PRADER-WILLI SYNDROME AND OBESE INDIVIDUALS .
26827493	0	GLUTAMATE	58,67	ERK1/2	25,31	GLUTAMATE	ERK1/2	D018698	50689;116590	Chemical	Gene	REGULATION|nmod|START_ENTITY REGULATION|compound|END_ENTITY	-LSB- MOLECULAR MECHANISMS OF ERK1/2 KINASES REGULATION IN THE GLUTAMATE - AND GABA-ERGIC NEURONS DURING SEIZURE EXPRESSION IN KRUSHINSKY-MOLODKINA RATS -RSB- .
17431782	0	GM-611	35,41	motilin	11,18	GM-611	motilin	MESH:C103741	574099(Tax:9544)	Chemical	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of motilin and mitemcinal -LRB- GM-611 -RRB- on gastrointestinal contractile activity in rhesus_monkeys in vivo and in vitro .
2839511	1	GM3	68,71	epidermal_growth_factor_receptor	120,152	GM3	epidermal growth factor receptor	CHEBI:15681	1956	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Specific effects of GM3 and lyso-GM3 in tyrosine phosphorylation of the epidermal_growth_factor_receptor .
8997244	0	GM611	60,65	motilin	43,50	GM611	motilin	MESH:C103741	100009276(Tax:9986)	Chemical	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	Electrophysiological characterization of a motilin agonist , GM611 , on rabbit duodenal smooth muscle .
22570471	0	GMX1778	88,95	NAMPT	54,59	GMX1778	NAMPT	MESH:C401312	10135	Chemical	Gene	activity|nmod|START_ENTITY activity|appos|END_ENTITY	Inhibition of nicotinamide_phosphoribosyltransferase -LRB- NAMPT -RRB- activity by small molecule GMX1778 regulates reactive oxygen species -LRB- ROS -RRB- - mediated cytotoxicity in a p53 - and nicotinic_acid phosphoribosyltransferase1 -LRB- NAPRT1 -RRB- - dependent manner .
22570471	0	GMX1778	88,95	nicotinamide_phosphoribosyltransferase	14,52	GMX1778	nicotinamide phosphoribosyltransferase	MESH:C401312	10135	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Inhibition of nicotinamide_phosphoribosyltransferase -LRB- NAMPT -RRB- activity by small molecule GMX1778 regulates reactive oxygen species -LRB- ROS -RRB- - mediated cytotoxicity in a p53 - and nicotinic_acid phosphoribosyltransferase1 -LRB- NAPRT1 -RRB- - dependent manner .
16773192	0	GN963	64,69	Src	40,43	GN963	Src	MESH:C521618	6714	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Inhibition of PDGFR phosphorylation and Src and Akt activity by GN963 leads to therapy of human pancreatic_cancer growing orthotopically in nude_mice .
24900443	0	GNF-5837	13,21	TRK	35,38	GNF-5837	TRK	null	18211(Tax:10090)	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|compound|END_ENTITY	Discovery of GNF-5837 , a Selective TRK Inhibitor with Efficacy in Rodent Cancer_Tumor Models .
21272158	0	GO-Y030	16,23	IKKb	48,52	GO-Y030	IKKb	MESH:C541015	3551	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Curcumin analog GO-Y030 is a novel inhibitor of IKKb that suppresses NF-kB signaling and induces apoptosis .
19724924	0	GO-Y030	18,25	STAT3	35,40	GO-Y030	STAT3	MESH:C541015	6774	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	Curcumin analogue GO-Y030 inhibits STAT3 activity and cell growth in breast_and_pancreatic_carcinomas .
21321532	7	GP130	1211,1216	IL-6	1205,1209	GP130	IL-6	MESH:C005759	16193(Tax:10090)	Chemical	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	Although hepatic IL-6 / GP130 signaling was activated in chow-fed db/db mice , this was suppressed in MCD diet-fed db/db mice , accompanied by downregulation of hepatic IL-6 receptor and GP130 mRNA expression .
9731623	0	GP683	54,59	adenosine_kinase	26,42	GP683	adenosine kinase	MESH:C108064	25368(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Delayed treatment with an adenosine_kinase inhibitor , GP683 , attenuates infarct size in rats with temporary_middle_cerebral_artery_occlusion .
7671828	0	GPA	49,52	GPAR_alpha	63,73	GPA	GPAR alpha	null	395885(Tax:9031)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Analysis of function and expression of the chick GPA receptor -LRB- GPAR_alpha -RRB- suggests multiple roles in neuronal development .
20724252	0	GPI-1046	0,8	presenilin-1	19,31	GPI-1046	presenilin-1	MESH:C104949	29192(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	GPI-1046 increases presenilin-1 expression and restores NMDA channel activity .
11561062	0	GPI5232	121,128	N-acetylated-alpha-linked_acidic_dipeptidase	65,109	GPI5232	N-acetylated-alpha-linked acidic dipeptidase	MESH:C436737	85309(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Electroencephalogram analysis and neuroprotective profile of the N-acetylated-alpha-linked_acidic_dipeptidase inhibitor , GPI5232 , in normal and brain-injured rats .
2592377	0	GPIIb-IIIa	61,71	thrombospondin	19,33	GPIIb-IIIa	thrombospondin	null	7057	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	The interaction of thrombospondin with platelet glycoprotein GPIIb-IIIa .
8012689	0	GR117289	26,34	AT1	56,59	GR117289	AT1	MESH:C078790	24180(Tax:10116)	Chemical	Gene	START_ENTITY|appos|receptor receptor|compound|END_ENTITY	Cardiovascular effects of GR117289 , a novel angiotensin AT1 receptor antagonist .
9088589	0	GR117289C	53,62	angiotensin_II	26,40	GR117289C	angiotensin II	null	183	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Effect of the non peptide angiotensin_II antagonist , GR117289C on the vasoconstrictor actions of angiotensin_II in the human forearm .
8788495	0	GR127935	0,8	5-HT1D	33,39	GR127935	5-HT1D	MESH:C090701	403963(Tax:9615)	Chemical	Gene	START_ENTITY|dep|antagonist antagonist|amod|END_ENTITY	GR127935 : a potent and selective 5-HT1D receptor antagonist .
7566469	0	GR127935	15,23	5-HT1D_receptor	36,51	GR127935	5-HT1D receptor	MESH:C090701	100379622(Tax:10141)	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|antagonist antagonist|amod|END_ENTITY	The effects of GR127935 , a putative 5-HT1D_receptor antagonist , on brain 5-HT metabolism , extracellular 5-HT concentration and behaviour in the guinea_pig .
7853190	0	GR138950	27,35	AT1	57,60	GR138950	AT1	MESH:C089586	24180(Tax:10116)	Chemical	Gene	START_ENTITY|appos|receptor receptor|compound|END_ENTITY	Pharmacological effects of GR138950 , a novel angiotensin AT1 receptor antagonist .
11709200	0	GR144053F	42,51	fibrinogen	11,21	GR144053F	fibrinogen	MESH:C090662	2244	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|antagonist antagonist|amod|END_ENTITY	Effects of fibrinogen receptor antagonist GR144053F and aurintricarboxylic_acid on platelet activation and degranulation .
8545524	0	GR159897	32,40	NK2_receptor	56,68	GR159897	NK2 receptor	MESH:C092990	6865	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	The anxiolytic-like activity of GR159897 , a non-peptide NK2_receptor antagonist , in rodent and primate models of anxiety .
9809472	0	GR203040	11,19	NK1	24,27	GR203040	NK1	MESH:C097591	6869	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Effects of GR203040 , an NK1 antagonist , on radiation - and cisplatin-induced tissue_damage in the ferret .
17897851	0	GR205171A	66,75	Fos	79,82	GR205171A	Fos	MESH:C496429	2353	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	The effects of ibuprofen and the neurokinin-1 receptor antagonist GR205171A on Fos expression in the ferret trigeminal nucleus following tooth pulp stimulation .
2962686	0	GR38032F	42,50	5-HT3_receptor	15,29	GR38032F	5-HT3 receptor	MESH:D017294	79246(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Effects of the 5-HT3_receptor antagonist , GR38032F , on raised dopaminergic activity in the mesolimbic system of the rat and marmoset brain .
1905233	0	GR70982	45,52	renin	29,34	GR70982	renin	MESH:C069475	5972	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|effects effects|nmod|END_ENTITY	Acute and chronic effects of renin inhibitor GR70982 in the conscious marmoset .
19010489	0	GRC-6211	0,8	TRPV1	30,35	GRC-6211	TRPV1	MESH:C572329	83810(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	GRC-6211 , a new oral specific TRPV1 antagonist , decreases_bladder_overactivity and noxious bladder input in cystitis animal models .
7537572	4	GRN	607,610	IL-6	584,588	GRN	IL-6	null	16193(Tax:10090)	Chemical	Gene	treatment|nmod|START_ENTITY END_ENTITY|nmod|treatment	Enhancement of the mRNA level of IL-6 by treatment with GRN was detected by reverse transcriptase-polymerase chain reaction -LRB- RT-PCR -RRB- .
8733580	0	GR_127935	64,73	5-HT1D_receptor	87,102	GR 127935	5-HT1D receptor	MESH:C090701	397309(Tax:9823)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Blockade of porcine carotid vascular response to sumatriptan by GR_127935 , a selective 5-HT1D_receptor antagonist .
22210877	0	GS-1101	18,25	PI3K	0,4	GS-1101	PI3K	MESH:C552946	5293	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|nummod|END_ENTITY	PI3K inhibitor , GS-1101 -LRB- CAL-101 -RRB- , attenuates pathway signaling , induces apoptosis , and overcomes signals from the microenvironment in cellular models of Hodgkin_lymphoma .
12419376	0	GS-4071	60,67	neuraminidase	23,36	GS-4071	neuraminidase	MESH:D053139	4758	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Design , synthesis , and neuraminidase inhibitory activity of GS-4071 analogues that utilize a novel hydrophobic paradigm .
25696919	0	GS-9973	46,53	Syk	68,71	GS-9973	Syk	null	6850	Chemical	Gene	trial|appos|START_ENTITY trial|appos|inhibitor inhibitor|compound|END_ENTITY	An open-label phase 2 trial of entospletinib -LRB- GS-9973 -RRB- , a selective Syk inhibitor , in chronic_lymphocytic_leukemia .
9514938	0	GS4071	0,6	neuraminidase	48,61	GS4071	neuraminidase	MESH:D053139	4758	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	GS4071 is a slow-binding inhibitor of influenza neuraminidase from both A and B strains .
24455189	0	GSB-106	43,50	BDNF	96,100	GSB-106	BDNF	null	24225(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Antidepressant Effect of Dimeric Dipeptide GSB-106 , an Original Low-Molecular-Weight Mimetic of BDNF .
9227791	0	GSH	38,41	GSH-Px	50,56	GSH	GSH-Px	CHEBI:16856	24404(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	The effect of iron supplementation on GSH levels , GSH-Px , and SOD activities of erythrocytes in L-thyroxine administration .
25037722	0	GSH	63,66	SOD1	24,28	GSH	SOD1	CHEBI:16856	853568(Tax:4932)	Chemical	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Secretion expression of SOD1 and its overlapping function with GSH in brewing yeast_strain for better flavor and anti-aging ability .
23496883	0	GSH	19,22	Sod1	50,54	GSH	Sod1	CHEBI:16856	6647	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	The involvement of GSH in the activation of human Sod1 linked to FALS in chronologically aged yeast cells .
1417970	1	GSH	47,50	cholesterol_7_alpha-hydroxylase	109,140	GSH	cholesterol 7 alpha-hydroxylase	CHEBI:16856	1581	Chemical	Gene	content|compound|START_ENTITY Effect|nmod|content Effect|nmod|END_ENTITY	Effect of GSH content of HepG2 cells on the activity and mRNA levels of cholesterol_7_alpha-hydroxylase .
17227450	0	GSH	96,99	gamma-glutamyl_transpeptidase	28,57	GSH	gamma-glutamyl transpeptidase	CHEBI:16856	92086	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	The effect of modulation of gamma-glutamyl_transpeptidase and nitric_oxide synthase activity on GSH homeostasis in HepG2 cells .
21393247	0	GSH	99,102	interleukin_6	77,90	GSH	interleukin 6	CHEBI:16856	16193(Tax:10090)	Chemical	Gene	release|compound|START_ENTITY release|amod|END_ENTITY	Intertissue flow of glutathione -LRB- GSH -RRB- as a tumor growth-promoting mechanism : interleukin_6 induces GSH release from hepatocytes in metastatic B16 melanoma-bearing mice .
20582872	0	GSK-1605786	0,11	CCR9	58,62	GSK-1605786	CCR9	null	10803	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|nmod|receptor receptor|compound|END_ENTITY	GSK-1605786 , a selective small-molecule antagonist of the CCR9 chemokine receptor for the treatment of Crohn 's _ disease .
21866096	0	GSK1018921	31,41	GlyT1	55,60	GSK1018921	GlyT1	MESH:C562323	6536	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	First-time-in-human study with GSK1018921 , a selective GlyT1 inhibitor : relationship between exposure and dizziness .
19284385	0	GSK1070916	32,42	Aurora_B	80,88	GSK1070916	Aurora B	MESH:C544308	20877(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|C C|compound|END_ENTITY	Biochemical characterization of GSK1070916 , a potent and selective inhibitor of Aurora_B and Aurora C kinases with an extremely long residence time1 .
19567821	0	GSK1070916	0,10	Aurora_B	21,29	GSK1070916	Aurora B	MESH:C544308	9212	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	GSK1070916 , a potent Aurora_B / C kinase inhibitor with broad antitumor activity in tissue culture cells and human tumor xenograft models .
20420387	0	GSK1070916	13,23	Aurora_B	61,69	GSK1070916	Aurora B	MESH:C544308	9212	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|C C|compound|END_ENTITY	Discovery of GSK1070916 , a potent and selective inhibitor of Aurora_B / C kinase .
21762492	0	GSK1070916	133,143	Aurora_B	115,123	GSK1070916	Aurora B	MESH:C544308	9212	Chemical	Gene	predictor|nmod|START_ENTITY predictor|nmod|inhibition inhibition|nmod|END_ENTITY	High chromosome number in hematological_cancer cell lines is a negative predictor of response to the inhibition of Aurora_B and C by GSK1070916 .
25195567	0	GSK1120212	26,36	MEK	11,14	GSK1120212	MEK	MESH:C560077	5609	Chemical	Gene	inhibitors|dobj|START_ENTITY inhibitors|nsubj|Effects Effects|nmod|END_ENTITY	Effects of MEK inhibitors GSK1120212 and PD0325901 in vivo using 10-plex quantitative proteomics and phosphoproteomics .
23067311	0	GSK1144814	99,109	NK1	70,73	GSK1144814	NK1	null	6869	Chemical	Gene	effects|dep|START_ENTITY effects|nmod|END_ENTITY	Pharmacokinetics and central nervous system effects of the novel dual NK1 / NK3_receptor antagonist GSK1144814 in alcohol-intoxicated volunteers .
26898301	0	GSK126	26,32	EZH2	10,14	GSK126	EZH2	MESH:C577920	2146	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	The novel EZH2 inhibitor , GSK126 , suppresses cell migration and angiogenesis via down-regulating VEGF-A .
24699248	0	GSK1292263	52,62	GPR119	36,42	GSK1292263	GPR119	null	139760	Chemical	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	Gut hormone pharmacology of a novel GPR119 agonist -LRB- GSK1292263 -RRB- , metformin , and sitagliptin in type_2_diabetes_mellitus : results from two randomized studies .
23641215	0	GSK1440115	45,55	Urotensin_II_Receptor	11,32	GSK1440115	Urotensin II Receptor	MESH:C554432	2837	Chemical	Gene	Antagonist|appos|START_ENTITY Antagonist|compound|END_ENTITY	Effects of Urotensin_II_Receptor Antagonist , GSK1440115 , in Asthma .
20718751	0	GSK1562590	0,10	urotensin-II_receptor	34,55	GSK1562590	urotensin-II receptor	MESH:C554431	57305(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	GSK1562590 , a slowly dissociating urotensin-II_receptor antagonist , exhibits prolonged pharmacodynamic activity ex vivo .
21778696	0	GSK1614343	0,10	ghrelin	20,27	GSK1614343	ghrelin	MESH:C556802	59301(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	GSK1614343 , a novel ghrelin receptor antagonist , produces an unexpected increase of food intake and body weight in rodents and dogs .
21034740	0	GSK1614343	69,79	ghrelin_receptor	40,56	GSK1614343	ghrelin receptor	MESH:C556802	84022(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	Pharmacological characterization of the ghrelin_receptor antagonist , GSK1614343 in rat RC-4B / C cells natively expressing GHS type 1a receptors .
26238593	0	GSK1838705A	0,11	IGF-1R	16,22	GSK1838705A	IGF-1R	MESH:C546191	3480	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	GSK1838705A , an IGF-1R inhibitor , inhibits glioma_cell_proliferation_and_suppresses_tumor growth in vivo .
25926740	0	GSK1838705A	0,11	insulin-like_growth_factor-1_receptor	16,53	GSK1838705A	insulin-like growth factor-1 receptor	MESH:C546191	3480	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	GSK1838705A , an insulin-like_growth_factor-1_receptor / insulin receptor inhibitor , induces apoptosis and reduces viability of docetaxel-resistant prostate_cancer cells both in vitro and in vivo .
24900589	0	GSK1842799	32,42	S1P1	58,62	GSK1842799	S1P1	null	1901	Chemical	Gene	START_ENTITY|nmod|Agonist Agonist|compound|END_ENTITY	Discovery of Clinical Candidate GSK1842799 As a Selective S1P1 Receptor Agonist -LRB- Prodrug -RRB- for Multiple_Sclerosis .
24333186	0	GSK2190915	29,39	FLAP	13,17	GSK2190915	FLAP	null	241	Chemical	Gene	Effects|appos|START_ENTITY Effects|nmod|inhibitor inhibitor|compound|END_ENTITY	Effects of a FLAP inhibitor , GSK2190915 , in asthmatics with high sputum neutrophils .
25486573	0	GSK2256098	39,49	FAK	17,20	GSK2256098	FAK	MESH:C000600809	5747	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	A small molecule FAK kinase inhibitor , GSK2256098 , inhibits growth and survival of pancreatic_ductal_adenocarcinoma cells .
23678871	0	GSK2330672	101,111	apical_sodium-dependent_bile_acid_transporter	44,89	GSK2330672	apical sodium-dependent bile acid transporter	null	6555	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Discovery of a highly potent , nonabsorbable apical_sodium-dependent_bile_acid_transporter inhibitor -LRB- GSK2330672 -RRB- for treatment of type 2 diabetes .
26179090	0	GSK2374697	0,10	GLP-1	128,133	GSK2374697	GLP-1	null	2641	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	GSK2374697 , a long duration glucagon-like_peptide-1 -LRB- GLP-1 -RRB- _ receptor agonist , reduces postprandial circulating endogenous total GLP-1 and peptide_YY in healthy subjects .
23701262	0	GSK256073	0,9	G-protein_coupled_receptor_109A	34,65	GSK256073	G-protein coupled receptor 109A	null	338442	Chemical	Gene	reduces|advmod|START_ENTITY reduces|nsubj|agonist agonist|nmod|END_ENTITY	GSK256073 , a selective agonist of G-protein_coupled_receptor_109A -LRB- GPR109A -RRB- reduces serum glucose in subjects with type_2_diabetes_mellitus .
22863203	0	GSK2578215A	0,11	LRRK2	90,95	GSK2578215A	LRRK2	null	66725(Tax:10090)	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	GSK2578215A ; a potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor .
27055521	0	GSK2586184	84,94	JAK1	69,73	GSK2586184	JAK1	null	3716	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|efficacy efficacy|nmod|END_ENTITY	Safety , tolerability , efficacy and pharmacodynamics of the selective JAK1 inhibitor GSK2586184 in patients with systemic_lupus_erythematosus .
24401334	0	GSK2656157	58,68	PERK	101,105	GSK2656157	PERK	null	9451	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Evidence for eIF2a phosphorylation-independent effects of GSK2656157 , a novel catalytic inhibitor of PERK with clinical implications .
26135714	0	GSK2795039	13,23	NADPH_Oxidase_2	48,63	GSK2795039	NADPH Oxidase 2	null	13058(Tax:10090)	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|compound|END_ENTITY	Discovery of GSK2795039 , a Novel Small Molecule NADPH_Oxidase_2 Inhibitor .
26832796	0	GSK2830371	75,85	p53	33,36	GSK2830371	p53	MESH:C587624	7157	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Chemical inhibition of wild-type p53 induced phosphatase 1 -LRB- WIP1/PPM1D -RRB- by GSK2830371 potentiates the sensitivity to MDM2 inhibitors in a p53-dependent manner .
25192198	0	GSK461364	75,84	Polo-like_Kinase_1	110,128	GSK461364	Polo-like Kinase 1	MESH:C561573	5347	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|nmod|END_ENTITY	Overexpression of Human ABCB1 in Cancer Cells Leads to Reduced Activity of GSK461364 , a Specific Inhibitor of Polo-like_Kinase_1 .
21459796	0	GSK461364	17,26	Polo-like_kinase_1	55,73	GSK461364	polo-like kinase 1	MESH:C561573	5347	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Phase I study of GSK461364 , a specific and competitive Polo-like_kinase_1 inhibitor , in patients with advanced solid malignancies .
18800763	0	GSK690693	150,159	AKT	183,186	GSK690693	AKT	MESH:C528328	207	Chemical	Gene	methyl-3-butyn-2-ol|appos|START_ENTITY methyl-3-butyn-2-ol|appos|inhibitor inhibitor|nmod|kinase kinase|compound|END_ENTITY	Identification of 4 - -LRB- 2 - -LRB- 4-amino-1 ,2,5 - oxadiazol-3-yl -RRB- -1 - ethyl-7 - -LCB- -LSB- -LRB- 3S -RRB- -3 - piperidinylmethyl -RSB- oxy -RCB- -1 H-imidazo -LSB- 4,5-c -RSB- pyridin-4-yl -RRB- -2 - methyl-3-butyn-2-ol -LRB- GSK690693 -RRB- , a novel inhibitor of AKT kinase .
19064730	0	GSK690693	15,24	AKT	0,3	GSK690693	AKT	MESH:C528328	207	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	AKT inhibitor , GSK690693 , induces growth inhibition and apoptosis in acute_lymphoblastic_leukemia cell lines .
20075391	0	GSK690693	0,9	Akt	102,105	GSK690693	Akt	MESH:C528328	11651(Tax:10090)	Chemical	Gene	delays|compound|START_ENTITY tumor|nsubj|delays tumor|xcomp|expressing expressing|dobj|END_ENTITY	GSK690693 delays tumor onset and progression in genetically defined mouse models expressing activated Akt .
19949058	0	GSK812397	46,55	CXCR4	81,86	GSK812397	CXCR4	null	7852	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Blockade of X4-tropic HIV-1 cellular entry by GSK812397 , a potent noncompetitive CXCR4 receptor antagonist .
22020315	0	GSK923295	29,38	CENP-E	106,112	GSK923295	CENP-E	MESH:C571460	1062	Chemical	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	First-time-in-human study of GSK923295 , a novel antimitotic inhibitor of centromere-associated_protein_E -LRB- CENP-E -RRB- , in patients with refractory_cancer .
24900171	0	GSK923295	90,99	Centromere-Associated_Protein_E	57,88	GSK923295	Centromere-Associated Protein E	MESH:C571460	1062	Chemical	Gene	Discovery|dep|START_ENTITY Discovery|nmod|END_ENTITY	Discovery of the First Potent and Selective Inhibitor of Centromere-Associated_Protein_E : GSK923295 .
22020315	0	GSK923295	29,38	centromere-associated_protein_E	73,104	GSK923295	centromere-associated protein E	MESH:C571460	1062	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	First-time-in-human study of GSK923295 , a novel antimitotic inhibitor of centromere-associated_protein_E -LRB- CENP-E -RRB- , in patients with refractory_cancer .
21584937	0	GSK923295A	40,50	CENP-E	23,29	GSK923295A	CENP-E	MESH:C571460	229841(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|testing testing|nmod|inhibitor inhibitor|compound|END_ENTITY	Initial testing of the CENP-E inhibitor GSK923295A by the pediatric preclinical testing program .
21895874	0	GSK962040	0,9	motilin	28,35	GSK962040	motilin	MESH:C541863	100009276(Tax:9986)	Chemical	Gene	START_ENTITY|dep|agonist agonist|compound|END_ENTITY	GSK962040 : a small molecule motilin receptor agonist which increases gastrointestinal_motility in conscious dogs .
18049312	0	GSPE	21,25	RAGE	29,33	GSPE	RAGE	null	177	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Inhibitory effect of GSPE on RAGE expression induced by advanced glycation end products in endothelial cells .
9517946	0	GS_4104	18,25	neuraminidase	83,96	GS 4104	neuraminidase	MESH:D053139	4758	Chemical	Gene	Identification|nmod|START_ENTITY END_ENTITY|nsubj|Identification	Identification of GS_4104 as an orally bioavailable prodrug of the influenza virus neuraminidase inhibitor GS_4071 .
25837937	0	GT-0198	20,27	glycine_transporter_2	50,71	GT-0198	glycine transporter 2	null	104245(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Analgesic effect of GT-0198 , a structurally novel glycine_transporter_2 inhibitor , in a mouse model of neuropathic_pain .
23911318	0	GTP	16,19	AMPD2	0,5	GTP	AMPD2	MESH:D006160	271	Chemical	Gene	synthesis|compound|START_ENTITY regulates|dobj|synthesis regulates|nsubj|END_ENTITY	AMPD2 regulates GTP synthesis and is mutated in a potentially treatable neurodegenerative brainstem_disorder .
26630542	12	GTP	1627,1630	ATP	1646,1649	GTP	NDK	MESH:D006160	129607	Chemical	Gene	synthesis|compound|START_ENTITY synthesis|nmod|END_ENTITY	Mutant NDK , partially deficient in GTP synthesis from ATP and GDP , triggered low level of polymerisation of MsFtsZ , but not of MtFtsZ .
23019516	0	GTP	0,3	Death_Associated_Protein_Kinase_1	63,96	GTP	Death Associated Protein Kinase 1	MESH:D006160	1612	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	GTP binding and intramolecular regulation by the ROC domain of Death_Associated_Protein_Kinase_1 .
16166657	0	GTP	78,81	EF-Tu	99,104	GTP	EF-Tu	MESH:D006160	7284	Chemical	Gene	hydrolyzed|nsubjpass|START_ENTITY hydrolyzed|nmod|END_ENTITY	Deacylated tRNA is released from the E site upon A site occupation but before GTP is hydrolyzed by EF-Tu .
3181143	0	GTP	40,43	EF-Tu	62,67	GTP	EF-Tu	MESH:D006160	1915	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Structure-function relationships in the GTP binding domain of EF-Tu : mutation of Val20 , the residue homologous to position 12 in p21 .
6127109	0	GTP	99,102	EF-Tu	70,75	GTP	EF-Tu	MESH:D006160	7284	Chemical	Gene	hydrolysis|compound|START_ENTITY hydrolysis|compound|END_ENTITY	Effect of thiostrepton and 3 ' - terminal fragments of aminoacyl-tRNA on EF-Tu and ribosome-dependent GTP hydrolysis .
6751396	0	GTP	60,63	EF-Tu	33,38	GTP	EF-Tu	MESH:D006160	7284	Chemical	Gene	gamma-amides|nmod|START_ENTITY END_ENTITY|nmod|gamma-amides	Interaction of elongation factor EF-Tu with gamma-amides of GTP and beta-amides of GDP bearing the azidoaryl group or the chloroethylaminoaryl group placed at the terminal phosphate .
19707569	5	GTP	960,963	GBF1	983,987	GTP	GBF1	MESH:D006160	36337(Tax:7227)	Chemical	Gene	mutant|compound|START_ENTITY mutant|nmod|END_ENTITY	Correspondingly , a GTP exchange mutant of GBF1 has altered ABD RFP localization in the evanescent field and is impaired in fluid phase uptake .
10391901	0	GTP	43,46	Galphaq	61,68	GTP	Galphaq	MESH:D006160	2776	Chemical	Gene	hydrolysis|compound|START_ENTITY hydrolysis|nmod|END_ENTITY	Phospholipase_C-beta1 directly accelerates GTP hydrolysis by Galphaq and acceleration is inhibited by Gbeta gamma subunits .
1932038	0	GTP	37,40	H-ras	53,58	GTP	H-ras	MESH:D006160	3265	Chemical	Gene	cleavage|compound|START_ENTITY cleavage|nmod|END_ENTITY	Is there a rate-limiting step before GTP cleavage by H-ras p21 ?
26184075	0	GTP	35,38	K-Ras	73,78	GTP	K-Ras	MESH:D006160	16653(Tax:10090)	Chemical	Gene	analogue|compound|START_ENTITY analogue|nmod|END_ENTITY	Interaction of a novel fluorescent GTP analogue with the small G-protein K-Ras .
10921930	0	GTP	72,75	Mog1p	51,56	GTP	Mog1p	MESH:D006160	853537(Tax:4932)	Chemical	Gene	release|compound|START_ENTITY stimulation|nmod|release stimulation|amod|END_ENTITY	Yrb1p interaction with the gsp1p C terminus blocks Mog1p stimulation of GTP release from Gsp1p .
25295396	0	GTP	45,48	MxA	32,35	GTP	MxA	MESH:D006160	4599	Chemical	Gene	Hydrolysis|compound|START_ENTITY Hydrolysis|compound|END_ENTITY	Transient Dimerization of Human MxA Promotes GTP Hydrolysis , Resulting in a Mechanical Power Stroke .
12506145	0	GTP	39,42	P53	0,3	GTP	P53	MESH:D006160	301300(Tax:10116)	Chemical	Gene	mediates|advcl|START_ENTITY mediates|nsubj|END_ENTITY	P53 mediates the apoptotic response to GTP depletion after renal_ischemia-reperfusion : protective role of a p53 inhibitor .
26774281	0	GTP	45,48	PI5P4Kb	17,24	GTP	PI5P4Kb	MESH:D006160	8396	Chemical	Gene	Sensor|compound|START_ENTITY Sensor|nsubj|END_ENTITY	The Lipid Kinase PI5P4Kb Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis .
16880209	0	GTP	54,57	Rab27	82,87	GTP	Rab27	MESH:D006160	5873	Chemical	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Constitutive GDP/GTP exchange and secretion-dependent GTP hydrolysis activity for Rab27 in platelets .
11879192	0	GTP	0,3	Rab3A	13,18	GTP	Rab3A	MESH:D006160	5864	Chemical	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	GTP binds to Rab3A in a complex with Ca2 + / calmodulin .
7929154	0	GTP	0,3	Rab3A	46,51	GTP	Rab3A	MESH:D006160	5864	Chemical	Gene	cleavage|compound|START_ENTITY cleavage|nmod|END_ENTITY	GTP cleavage by the small GTP-binding protein Rab3A is associated with exocytosis of synaptic vesicles induced by alpha-latrotoxin .
10381206	0	GTP	14,17	Rac2	29,33	GTP	Rac2	MESH:D006160	5880	Chemical	Gene	START_ENTITY|amod|binding binding|nmod|END_ENTITY	Inhibition of GTP binding to Rac2 by peroxynitrite : potential role for tyrosine modification .
10911995	0	GTP	0,3	Ran	18,21	GTP	Ran	MESH:D006160	100189578(Tax:8355)	Chemical	Gene	hydrolysis|compound|START_ENTITY hydrolysis|nmod|END_ENTITY	GTP hydrolysis by Ran is required for nuclear envelope assembly .
7593180	0	GTP	0,3	Ran	18,21	GTP	Ran	MESH:D006160	5901	Chemical	Gene	hydrolysis|compound|START_ENTITY hydrolysis|nmod|END_ENTITY	GTP hydrolysis by Ran occurs at the nuclear pore complex in an early step of protein import .
3289616	0	GTP	29,32	RecA	36,40	GTP	RecA	MESH:D006160	5888	Chemical	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	ATP-stimulated hydrolysis of GTP by RecA protein : kinetic consequences of cooperative RecA protein-ATP interactions .
22819219	0	GTP	43,46	Rheb	61,65	GTP	Rheb	MESH:D006160	6009	Chemical	Gene	hydrolysis|compound|START_ENTITY hydrolysis|nmod|END_ENTITY	An autoinhibited noncanonical mechanism of GTP hydrolysis by Rheb maintains mTORC1 homeostasis .
8641285	0	GTP	73,76	Rho1p	61,66	GTP	Rho1p	MESH:D006160	856294(Tax:4932)	Chemical	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	Rom1p and Rom2p are GDP/GTP exchange proteins -LRB- GEPs -RRB- for the Rho1p small GTP binding protein in Saccharomyces_cerevisiae .
1569938	0	GTP	14,17	Sec4	21,25	GTP	Sec4	MESH:D006160	850543(Tax:4932)	Chemical	Gene	START_ENTITY|nmod|protein protein|amod|END_ENTITY	Hydrolysis of GTP by Sec4 protein plays an important role in vesicular transport and is stimulated by a GTPase-activating protein in Saccharomyces_cerevisiae .
2504727	0	GTP	50,53	Sec4	71,75	GTP	Sec4	MESH:D006160	850543(Tax:4932)	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	The Sec15 protein responds to the function of the GTP binding protein , Sec4 , to control vesicular traffic in yeast .
2829820	0	GTP	65,68	angiotensin_II	38,52	GTP	angiotensin II	MESH:D006160	24179(Tax:10116)	Chemical	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Different effects of phorbol_ester on angiotensin_II - and stable GTP analogue-induced activation of polyphosphoinositide phosphodiesterase in membranes isolated from rat renal mesangial cells .
10464099	0	GTP	0,3	class_II_transactivator	15,38	GTP	class II transactivator	MESH:D006160	4261	Chemical	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	GTP binding by class_II_transactivator : role in nuclear import .
8407925	0	GTP	0,3	eEF-2	33,38	GTP	eEF-2	MESH:D006160	29565(Tax:10116)	Chemical	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	GTP binding to elongation factor eEF-2 unmasks a tryptophan residue required for biological activity .
10216940	3	GTP	289,292	eIF2	302,306	GTP	eIF2	MESH:D006160	8894	Chemical	Gene	START_ENTITY|acl|bound bound|nmod|END_ENTITY	At the end of the initiation process , GTP bound to eIF2 is hydrolyzed to GDP and the eIF2.GDP complex is released from the ribosome .
11600502	0	GTP	22,25	glutamate_dehydrogenase	48,71	GTP	glutamate dehydrogenase	MESH:D006160	2746	Chemical	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Identification of the GTP binding site of human glutamate_dehydrogenase by cassette mutagenesis and photoaffinity labeling .
16292343	0	GTP	65,68	mDia1	18,23	GTP	mDia1	MESH:D006160	13367(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|END_ENTITY	The regulation of mDia1 by autoinhibition and its release by Rho * GTP .
9405048	0	GTP	4,7	ornithine_decarboxylase	25,48	GTP	ornithine decarboxylase	MESH:D006160	4953	Chemical	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	The GTP effector site of ornithine_decarboxylase from Lactobacillus 30a : kinetic and structural characterization .
7935432	0	GTP	56,59	p190_RhoGAP	0,11	GTP	p190 RhoGAP	MESH:D006160	2909	Chemical	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	p190_RhoGAP , the major RasGAP-associated protein , binds GTP directly .
1447167	0	GTP	64,67	p21	89,92	GTP	p21	MESH:D006160	644914	Chemical	Gene	complex|compound|START_ENTITY complex|nmod|END_ENTITY	A mouse CDC25-like product enhances the formation of the active GTP complex of human ras p21 and Saccharomyces_cerevisiae RAS2 proteins .
1883817	0	GTP	0,3	p21	33,36	GTP	p21	MESH:D006160	644914	Chemical	Gene	hydrolysis|nsubj|START_ENTITY hydrolysis|nmod|END_ENTITY	GTP hydrolysis mechanisms in ras p21 and in the ras-GAP complex studied by fluorescence measurements on tryptophan mutants .
2111712	0	GTP	29,32	rab2	15,19	GTP	rab2	MESH:D006160	65158(Tax:10116)	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	The product of rab2 , a small GTP binding protein , increases neuronal_adhesion , and neurite growth in vitro .
10398417	0	GTP	14,17	rab3a	35,40	GTP	rab3a	MESH:D006160	19339(Tax:10090)	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	The monomeric GTP binding protein , rab3a , is associated with the acrosome in mouse sperm .
8855260	0	GTP	56,59	synexin	24,31	GTP	synexin	MESH:D006160	310	Chemical	Gene	sensor|compound|START_ENTITY END_ENTITY|nmod|sensor	Membrane fusion protein synexin -LRB- annexin_VII -RRB- as a Ca2 + / GTP sensor in exocytotic secretion .
2820381	0	GTP	157,160	thrombin	129,137	GTP	thrombin	MESH:D006160	100009146(Tax:9986)	Chemical	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	Activation of phospholipase_C associated with isolated rabbit platelet membranes by guanosine_5 ' - -LSB- gamma-thio -RSB- triphosphate and by thrombin in the presence of GTP .
8573173	0	GTP	0,3	tissue_transglutaminase	24,47	GTP	tissue transglutaminase	MESH:D006160	7052	Chemical	Gene	hydrolysis|nsubj|START_ENTITY hydrolysis|nmod|END_ENTITY	GTP hydrolysis by human tissue_transglutaminase homologue .
12475976	0	GTP	107,110	trio	39,43	GTP	trio	MESH:D006160	7204	Chemical	Gene	activates|advcl|START_ENTITY activates|nsubj|END_ENTITY	The guanine_nucleotide exchange factor trio activates the phagocyte NADPH oxidase in the absence of GDP to GTP exchange on Rac .
25009619	0	GTS-21	0,6	a7-nicotinic_acetylcholine_receptor	11,46	GTS-21	a7-nicotinic acetylcholine receptor	MESH:C088936	1139	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	GTS-21 , an a7-nicotinic_acetylcholine_receptor agonist , modulates Th1 differentiation in CD4 -LRB- + -RRB- T cells from patients with rheumatoid_arthritis .
23341496	0	GW-9508	23,30	G_protein-coupled_receptor_40	44,73	GW-9508	G protein-coupled receptor 40	MESH:C515630	233081(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Multiple mechanisms of GW-9508 , a selective G_protein-coupled_receptor_40 agonist , in the regulation of glucose homeostasis and insulin sensitivity .
21244753	0	GW0742	0,6	PPAR-b	24,30	GW0742	PPAR-b	MESH:C479979	19015(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	GW0742 , a high affinity PPAR-b / agonist reduces lung_inflammation induced by bleomycin instillation in mice .
18097603	0	GW1929	33,39	PPARgamma	15,24	GW1929	PPARgamma	MESH:C120099	19016(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|agonist agonist|compound|END_ENTITY	Effects of the PPARgamma agonist GW1929 on muscle wasting in tumour-bearing mice .
24412748	0	GW1929	0,6	nAChR	19,24	GW1929	nAChR	MESH:C120099	1137	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	GW1929 inhibits a7 nAChR expression through PPARy-independent activation of p38 MAPK and inactivation of PI3-K/mTOR : The role of Egr-1 .
12393067	0	GW274150	22,30	iNOS	75,79	GW274150	iNOS	MESH:C409004	18126(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|inhibitor inhibitor|nmod|activity activity|amod|END_ENTITY	Beneficial effects of GW274150 , a novel , potent and selective inhibitor of iNOS activity , in a rodent model of collagen-induced arthritis .
12631066	0	GW274150	0,8	iNOS	53,57	GW274150	iNOS	MESH:C409004	18126(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	GW274150 , a potent and highly selective inhibitor of iNOS , reduces experimental renal_ischemia / reperfusion injury .
14769784	0	GW274150	11,19	iNOS	56,60	GW274150	iNOS	MESH:C409004	24599(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|inhibitor inhibitor|nmod|activity activity|amod|END_ENTITY	Effects of GW274150 , a novel and selective inhibitor of iNOS activity , in acute_lung_inflammation .
16360270	0	GW274150	0,8	iNOS	100,104	GW274150	iNOS	MESH:C409004	24599(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|isoform isoform|nmod|synthase synthase|appos|END_ENTITY	GW274150 , a novel and highly selective inhibitor of the inducible isoform of nitric_oxide synthase -LRB- iNOS -RRB- , shows analgesic effects in rat models of inflammatory and neuropathic_pain .
16699825	0	GW274150	72,80	iNOS	56,60	GW274150	iNOS	MESH:C409004	18126(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	y + _ LAT-1 mediates transport of the potent and selective iNOS inhibitor , GW274150 , in control J774 macrophages .
20974604	0	GW274150	49,57	iNOS	34,38	GW274150	iNOS	MESH:C409004	51477	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|Lack Lack|nmod|efficacy efficacy|nmod|END_ENTITY	Lack of efficacy of the selective iNOS inhibitor GW274150 in prophylaxis of migraine_headache .
21185368	0	GW274150	48,56	iNOS	33,37	GW274150	iNOS	MESH:C409004	4843	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|Neuroprotection Neuroprotection|nmod|END_ENTITY	Neuroprotection by the selective iNOS inhibitor GW274150 in a model of Parkinson_disease .
15691827	3	GW280264X	714,723	ADAM17	696,702	GW280264X	ADAM17	MESH:C492546	11491(Tax:10090)	Chemical	Gene	inhibitors|dobj|START_ENTITY inhibitors|nsubj|END_ENTITY	This shedding was inhibited by the broad range metalloproteinase inhibitor GM6001 , the two potent ADAM17 inhibitors GW280264X and TAPI-2 , and was absent in mice lacking functional ADAM17 -LRB- ADAM17 lacking Zn-binding domain ; ADAM17 -LRB- DeltaZn/DeltaZn -RRB- -RRB- .
23446231	0	GW3965	18,24	LXR	0,3	GW3965	LXR	MESH:C473027	22259(Tax:10090)	Chemical	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	LXR activation by GW3965 alters fat tissue distribution and adipose tissue inflammation in ob/ob female mice .
21889608	0	GW3965	16,22	apoA-I	33,39	GW3965	apoA-I	MESH:C473027	11806(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|amod|END_ENTITY	The LXR agonist GW3965 increases apoA-I protein levels in the central nervous system independent of ABCA1 .
23349715	0	GW3965	29,35	apolipoprotein_E	121,137	GW3965	apolipoprotein E	MESH:C473027	11816(Tax:10090)	Chemical	Gene	improves|nsubj|START_ENTITY improves|nmod|END_ENTITY	The liver X receptor agonist GW3965 improves recovery from mild repetitive traumatic_brain_injury in mice partly through apolipoprotein_E .
20863899	0	GW405833	60,68	CB2	39,42	GW405833	CB2	MESH:C463040	57302(Tax:10116)	Chemical	Gene	agonist|dobj|START_ENTITY agonist|nsubj|effects effects|nmod|receptor receptor|compound|END_ENTITY	Paradoxical effects of the cannabinoid CB2 receptor agonist GW405833 on rat osteoarthritic knee joint pain .
17055166	0	GW406381	0,8	COX-2	18,23	GW406381	COX-2	MESH:C469818	29527(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	GW406381 , a novel COX-2 inhibitor , attenuates spontaneous ectopic discharge in sural nerves of rats following chronic constriction_injury .
19409858	0	GW406381	85,93	COX-2	68,73	GW406381	COX-2	MESH:C469818	4513	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	A randomized , double-blind , placebo-controlled trial of a selective COX-2 inhibitor , GW406381 , in patients with postherpetic_neuralgia .
18312401	0	GW406381	101,109	cyclooxygenase-2	73,89	GW406381	cyclooxygenase-2	MESH:C469818	5743	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	A double-blind , randomized , placebo-controlled , single-dose study of the cyclooxygenase-2 inhibitor , GW406381 , as a treatment for acute migraine .
25725071	0	GW4064	0,6	Farnesoid_X_Receptor	22,42	GW4064	Farnesoid X Receptor	MESH:C412815	9971	Chemical	Gene	START_ENTITY|appos|Agonist Agonist|nmod|END_ENTITY	GW4064 , an Agonist of Farnesoid_X_Receptor -LRB- FXR -RRB- , Represses CYP3A4 Expression in Human Hepatocytes .
14623915	0	GW4064	53,59	farnesoid_X_receptor	24,44	GW4064	farnesoid X receptor	MESH:C412815	60351(Tax:10116)	Chemical	Gene	agonist|dobj|START_ENTITY agonist|nsubj|Hepatoprotection Hepatoprotection|nmod|END_ENTITY	Hepatoprotection by the farnesoid_X_receptor agonist GW4064 in rat models of intra - and extrahepatic cholestasis .
19410460	0	GW4064	68,74	farnesoid_X_receptor	33,53	GW4064	farnesoid X receptor	MESH:C412815	9971	Chemical	Gene	agonist|dobj|START_ENTITY agonist|nsubj|analogs analogs|nmod|END_ENTITY	Substituted isoxazole analogs of farnesoid_X_receptor -LRB- FXR -RRB- agonist GW4064 .
21660973	0	GW4064	89,95	farnesoid_X_receptor	59,79	GW4064	farnesoid X receptor	MESH:C412815	9971	Chemical	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	A formulation-enabled preclinical efficacy assessment of a farnesoid_X_receptor agonist , GW4064 , in hamsters and cynomolgus_monkeys .
23101941	0	GW4064	22,28	farnesoid_X_receptor	40,60	GW4064	farnesoid X receptor	MESH:C412815	9971	Chemical	Gene	pathways|nmod|START_ENTITY pathways|nmod|END_ENTITY	Unbinding pathways of GW4064 from human farnesoid_X_receptor as revealed by molecular_dynamics simulations .
25400456	0	GW4064	0,6	farnesoid_X_receptor	10,30	GW4064	farnesoid X receptor	MESH:C412815	20186(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	GW4064 , a farnesoid_X_receptor agonist , upregulates adipokine expression in preadipocytes and HepG2 cells .
25499883	0	GW4064	32,38	farnesoid_X_receptor	42,62	GW4064	farnesoid X receptor	MESH:C412815	9971	Chemical	Gene	scaffolds|nmod|START_ENTITY scaffolds|nmod|agonists agonists|compound|END_ENTITY	Novel heterocyclic scaffolds of GW4064 as farnesoid_X_receptor agonists .
25934227	0	GW4064	17,23	farnesoid_X_receptor	55,75	GW4064	farnesoid X receptor	MESH:C412815	9971	Chemical	Gene	Fragmentation|nmod|START_ENTITY led|nsubj|Fragmentation led|nmod|agonist agonist|compound|END_ENTITY	Fragmentation of GW4064 led to a highly potent partial farnesoid_X_receptor agonist with improved drug-like properties .
19266055	0	GW501516	18,26	PPAR	4,8	GW501516	PPAR	MESH:C425931	19013(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY ligand|ccomp|reduces ligand|nsubj|END_ENTITY	The PPAR ligand GW501516 reduces growth but not apoptosis in mouse inner medullary collecting_duct cells .
21966476	0	GW501516	0,8	PPAR	12,16	GW501516	PPAR	MESH:C425931	19013(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	GW501516 , a PPAR agonist , ameliorates tubulointerstitial inflammation in proteinuric_kidney_disease via inhibition of TAK1-NFkB pathway in mice .
22179221	0	GW501516	67,75	PPAR	48,52	GW501516	PPAR	MESH:C425931	5465	Chemical	Gene	inhibits|advmod|START_ENTITY agonist|dep|inhibits peroxisome_proliferator-activated_receptor|dep|agonist peroxisome_proliferator-activated_receptor|appos|END_ENTITY	The peroxisome_proliferator-activated_receptor -LRB- PPAR -RRB- b / agonist GW501516 inhibits IL-6-induced signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- activation and insulin resistance in human liver cells .
24708238	0	GW501516	76,84	PPAR	59,63	GW501516	PPAR	MESH:C425931	25747(Tax:10116)	Chemical	Gene	Effects|dep|START_ENTITY Effects|nmod|peroxisome_proliferator-activated_receptor peroxisome_proliferator-activated_receptor|appos|END_ENTITY	Effects of the peroxisome_proliferator-activated_receptor -LRB- PPAR -RRB- - agonist GW501516 on bone and muscle in ovariectomized rats .
25943561	0	GW501516	42,50	PPAR	27,31	GW501516	PPAR	MESH:C425931	19013(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|study study|nmod|agonist agonist|amod|END_ENTITY	A metabolomic study of the PPAR agonist GW501516 for enhancing running endurance in Kunming mice .
25943561	0	GW501516	42,50	PPAR	27,31	GW501516	PPAR	MESH:C425931	19013(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|study study|nmod|agonist agonist|amod|END_ENTITY	A metabolomic study of the PPAR agonist GW501516 for enhancing running endurance in Kunming mice .
16574099	0	GW501516	46,54	PPARdelta	56,65	GW501516	PPARdelta	MESH:C425931	19015(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Effects of bezafibrate , PPAR pan-agonist , and GW501516 , PPARdelta agonist , on development of steatohepatitis in mice fed a methionine - _ and_choline-deficient diet .
17869249	0	GW501516	23,31	PPARdelta	4,13	GW501516	PPARdelta	MESH:C425931	25682(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	The PPARdelta agonist , GW501516 , promotes fatty_acid oxidation but has no direct effect on glucose utilisation or insulin sensitivity in rat L6 skeletal muscle cells .
24708238	0	GW501516	76,84	peroxisome_proliferator-activated_receptor	15,57	GW501516	peroxisome proliferator-activated receptor	MESH:C425931	25747(Tax:10116)	Chemical	Gene	Effects|dep|START_ENTITY Effects|nmod|END_ENTITY	Effects of the peroxisome_proliferator-activated_receptor -LRB- PPAR -RRB- - agonist GW501516 on bone and muscle in ovariectomized rats .
16750187	0	GW5074	97,103	Raf-1	80,85	GW5074	Raf-1	MESH:C489251	5894	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Chronic morphine-mediated adenylyl cyclase superactivation is attenuated by the Raf-1 inhibitor , GW5074 .
23512845	0	GW803430	40,48	MCHR1	22,27	GW803430	MCHR1	MESH:C540748	207911(Tax:10090)	Chemical	Gene	Effects|appos|START_ENTITY Effects|nmod|antagonist antagonist|compound|END_ENTITY	Effects of a specific MCHR1 antagonist -LRB- GW803430 -RRB- on energy budget and glucose metabolism in diet-induced obese mice .
22242153	0	GW8510	0,6	insulin	17,24	GW8510	insulin	MESH:C500810	3630	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	GW8510 increases insulin expression in pancreatic alpha cells through activation of p53 transcriptional activity .
15533890	0	GW9662	0,6	PPARgamma	31,40	GW9662	PPARgamma	MESH:C457499	5468	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|nmod|END_ENTITY	GW9662 , a potent antagonist of PPARgamma , inhibits growth of breast_tumour cells and promotes the anticancer effects of the PPARgamma agonist rosiglitazone , independently of PPARgamma activation .
17096328	3	GW9662	661,667	PPARgamma	753,762	GW9662	PPARgamma	MESH:C457499	5468	Chemical	Gene	T0070907|dep|START_ENTITY doses|appos|T0070907 affect|nsubj|doses affect|advcl|caused caused|nsubj|doses doses|nmod|inhibitors inhibitors|compound|END_ENTITY	Low doses -LRB- 0.1-1 microM -RRB- of PPARgamma inhibitors -LRB- T0070907 , GW9662 and BADGE -RRB- did not affect cell survival , while higher doses -LRB- 10-100 microM -RRB- of all 3 PPARgamma inhibitors caused caspase-dependent apoptosis in HT-29 , Caco-2 and LoVo CRC cell lines .
23001870	0	GW9662	17,23	estrogen_receptor	43,60	GW9662	estrogen receptor	MESH:C457499	2099	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	PPARy antagonist GW9662 induces functional estrogen_receptor in mouse mammary organ culture : potential translational significance .
20538760	0	GX15-070	92,100	Bcl-2	60,65	GX15-070	Bcl-2	MESH:C520962	596	Chemical	Gene	START_ENTITY|amod|homology homology|amod|END_ENTITY	The combination of a histone deacetylase inhibitor with the Bcl-2 homology domain-3 mimetic GX15-070 has synergistic antileukemia activity by activating both apoptosis and autophagy .
21822052	0	GX15-070	76,84	DR5	42,45	GX15-070	DR5	MESH:C520962	8795	Chemical	Gene	inhibition|appos|START_ENTITY inhibition|nmod|END_ENTITY	Mcl-1 and YY1 inhibition and induction of DR5 by the BH3-mimetic Obatoclax -LRB- GX15-070 -RRB- contribute in the sensitization of B-NHL cells to TRAIL apoptosis .
21822052	0	GX15-070	76,84	Mcl-1	0,5	GX15-070	Mcl-1	MESH:C520962	4170	Chemical	Gene	inhibition|appos|START_ENTITY inhibition|compound|END_ENTITY	Mcl-1 and YY1 inhibition and induction of DR5 by the BH3-mimetic Obatoclax -LRB- GX15-070 -RRB- contribute in the sensitization of B-NHL cells to TRAIL apoptosis .
1578372	0	GYKI-14766	131,141	thrombin	73,81	GYKI-14766	thrombin	MESH:C064289	2147	Chemical	Gene	assessment|appos|START_ENTITY assessment|nmod|activity activity|nmod|inhibitor inhibitor|compound|END_ENTITY	Pharmacological assessment of the antithrombotic activity of the peptide thrombin inhibitor , D-methyl-phenylalanyl-prolyl-arginal -LRB- GYKI-14766 -RRB- , in a canine model of coronary_artery_thrombosis .
7976393	0	GYKI-14766	58,68	thrombin	35,43	GYKI-14766	thrombin	MESH:C064289	2147	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|effect effect|nmod|END_ENTITY	Biochemical effect and kinetics of thrombin inhibition by GYKI-14766 .
21938414	0	GZ-793A	39,46	VMAT2	22,27	GZ-793A	VMAT2	MESH:C573789	25549(Tax:10116)	Chemical	Gene	effect|amod|START_ENTITY effect|nmod|END_ENTITY	The effect of a novel VMAT2 inhibitor , GZ-793A , on methamphetamine reward in rats .
22638813	0	GZ-793A	30,37	VMAT2	14,19	GZ-793A	VMAT2	MESH:C573789	25549(Tax:10116)	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|effect effect|nmod|END_ENTITY	The effect of VMAT2 inhibitor GZ-793A on the reinstatement of methamphetamine-seeking in rats .
23597792	0	GZ-793A	23,30	VMAT2	113,118	GZ-793A	VMAT2	MESH:C573789	6571	Chemical	Gene	analogs|nmod|START_ENTITY analogs|dep|synthesis synthesis|nmod|inhibitors inhibitors|nmod|vesicular_monoamine_transporter-2 vesicular_monoamine_transporter-2|appos|END_ENTITY	Pyrrolidine analogs of GZ-793A : synthesis and evaluation as inhibitors of the vesicular_monoamine_transporter-2 -LRB- VMAT2 -RRB- .
16360136	0	GaC-Tf-FeN	51,61	transferrin	20,31	GaC-Tf-FeN	transferrin	null	7018	Chemical	Gene	transport|amod|START_ENTITY transport|amod|END_ENTITY	Characterization of transferrin receptor-dependent GaC-Tf-FeN transport in human leukemic HL60 cells .
23795861	0	Gaba	0,4	SLC6A11	17,24	Gaba	SLC6A11	MESH:D005680	6538	Chemical	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	Gaba transporter SLC6A11 gene polymorphism associated with tardive_dyskinesia .
17873287	0	Gabapentin	0,10	c-Fos	60,65	Gabapentin	c-Fos	MESH:C040029	314322(Tax:10116)	Chemical	Gene	attenuated|nsubj|START_ENTITY attenuated|dobj|morphine morphine|acl|induced induced|dobj|expression expression|amod|END_ENTITY	Gabapentin completely attenuated the acute morphine induced c-Fos expression in the rat striatum .
20734160	0	Gabapentin	0,10	c-Fos	60,65	Gabapentin	c-Fos	MESH:C040029	314322(Tax:10116)	Chemical	Gene	attenuated|nsubj|START_ENTITY attenuated|dobj|expression expression|amod|END_ENTITY	Gabapentin completely attenuated the acute morphine-induced c-Fos expression in the rat nucleus accumbens .
24247277	0	Gabapentin	0,10	interleukin-10	49,63	Gabapentin	interleukin-10	MESH:C040029	25325(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|advcl|END_ENTITY	Gabapentin attenuates morphine tolerance through interleukin-10 .
19766246	0	Gabexate_mesilate	0,17	HMGB1	45,50	Gabexate mesilate	HMGB1	MESH:D016670	25459(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Gabexate_mesilate inhibits the expression of HMGB1 in lipopolysaccharide-induced acute_lung_injury .
2412725	0	Gabexate_mesilate	0,17	phospholipase_A2	51,67	Gabexate mesilate	phospholipase A2	MESH:D016670	151056	Chemical	Gene	START_ENTITY|dep|inhibitors inhibitors|nmod|END_ENTITY	Gabexate_mesilate and camostate : new inhibitors of phospholipase_A2 and their influence on the alpha-amylase activity in serum of patients with acute_pancreatitis .
12649382	0	Gabexate_mesilate	0,17	tumor_necrosis_factor-alpha	87,114	Gabexate mesilate	tumor necrosis factor-alpha	MESH:D016670	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Gabexate_mesilate , a synthetic protease inhibitor , inhibits lipopolysaccharide-induced tumor_necrosis_factor-alpha production by inhibiting activation of both nuclear_factor-kappaB and activator_protein-1 in human monocytes .
9394032	0	Gadolinium_chloride	0,19	microsomal_epoxide_hydrolase	46,74	Gadolinium chloride	microsomal epoxide hydrolase	MESH:C038958	25315(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|inhibition inhibition|nmod|END_ENTITY	Gadolinium_chloride inhibition of rat hepatic microsomal_epoxide_hydrolase and glutathione_S-transferase gene expression .
1400309	1	GalNAc	87,93	beta_1	133,139	GalNAc	beta 1	CHEBI:28037	10678	Chemical	Gene	moiety|amod|START_ENTITY moiety|nmod|END_ENTITY	The enzymatic transfer of Gal in beta_1 ,3 linkage to the GalNAc moiety of the core structure R1-GlcNAc beta_1 ,6 GalNAc alpha-O-R2 .
10926297	0	Galactose	0,9	galactose-1-phosphate_uridyltransferase	39,78	Galactose	galactose-1-phosphate uridyltransferase	MESH:D005690	14430(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mouse mouse|nmod|deficiency deficiency|amod|END_ENTITY	Galactose metabolism by the mouse with galactose-1-phosphate_uridyltransferase deficiency .
10960497	0	Galactose	0,9	galactose-1-phosphate_uridyltransferase	58,97	Galactose	galactose-1-phosphate uridyltransferase	MESH:D005690	2592	Chemical	Gene	testing|amod|START_ENTITY distinguishes|nsubj|testing distinguishes|dobj|genotypes genotypes|amod|END_ENTITY	Galactose breath testing distinguishes variant and severe galactose-1-phosphate_uridyltransferase genotypes .
11286504	0	Galactose	0,9	galactose-1-phosphate_uridyltransferase	34,73	Galactose	galactose-1-phosphate uridyltransferase	MESH:D005690	14430(Tax:10090)	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|nmod|mice mice|nmod|deficiency deficiency|amod|END_ENTITY	Galactose metabolism in mice with galactose-1-phosphate_uridyltransferase deficiency : sucklings and 7-week-old animals fed a high-galactose diet .
2105103	0	Galactose	0,9	lactase	19,26	Galactose	lactase	MESH:D005690	226413(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Galactose inhibits lactase expression by mouse jejunal enterocytes .
24028940	0	Galangin	0,8	AMPK	61,65	Galangin	AMPK	MESH:C037032	5563	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|activating activating|dobj|END_ENTITY	Galangin inhibits proliferation of HepG2 cells by activating AMPK via increasing the AMP/TAN ratio in a LKB1-independent manner .
20452337	0	Galangin	0,8	acetylcholinesterase	73,93	Galangin	acetylcholinesterase	MESH:C037032	43	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Galangin , a flavonol derived from Rhizoma Alpiniae Officinarum , inhibits acetylcholinesterase activity in vitro .
22575016	0	Galangin	0,8	caspase_8	73,82	Galangin	caspase 8	MESH:C037032	841	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|pathway pathway|amod|END_ENTITY	Galangin induces apoptosis in hepatocellular_carcinoma cells through the caspase_8 / t-Bid mitochondrial pathway .
17143559	0	Galanin	0,7	GAL-R1	108,114	Galanin	GAL-R1	MESH:D019004	50577(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|advcl|dispersed dispersed|nmod|activation activation|nmod|receptors receptors|compound|END_ENTITY	Galanin enhances corticosterone secretion from dispersed rat adrenocortical cells through the activation of GAL-R1 and GAL-R2 receptors coupled to the adenylate cyclase-dependent signaling cascade .
23142608	0	Galanin	0,7	GalR1	17,22	Galanin	GalR1	MESH:D019004	50577(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|nmod|END_ENTITY	Galanin , through GalR1 but not GalR2 receptors , decreases motivation at times of high appetitive behavior .
15944007	0	Galanin	0,7	GalR3	24,29	Galanin	GalR3	MESH:D019004	29235(Tax:10116)	Chemical	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Galanin -LRB- 2-11 -RRB- binds to GalR3 in transfected cell lines : limitations for pharmacological definition of receptor subtypes .
7688586	0	Galanin	0,7	cholecystokinin	34,49	Galanin	cholecystokinin	MESH:D019004	25298(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|nmod|END_ENTITY	Galanin stimulates the release of cholecystokinin from nerve fibres in the pituitary_neurointermediate_lobe .
1692187	0	Galanin	0,7	gastrin	17,24	Galanin	gastrin	MESH:D019004	25320(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|compound|END_ENTITY	Galanin inhibits gastrin release from isolated rat gastric G-cells .
1283476	0	Galanin	0,7	growth_hormone	72,86	Galanin	growth hormone	MESH:D019004	2688	Chemical	Gene	affect|nsubj|START_ENTITY affect|dobj|secretion secretion|compound|END_ENTITY	Galanin does not affect the growth_hormone-releasing_hormone-stimulated growth_hormone secretion in patients with hyperthyroidism .
2452948	0	Galanin	0,7	growth_hormone	33,47	Galanin	growth hormone	MESH:D019004	81668(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|xcomp|rat rat|dobj|secretion secretion|amod|END_ENTITY	Galanin stimulates rat pituitary growth_hormone secretion in vitro .
7532779	0	Galanin	0,7	growth_hormone	65,79	Galanin	growth hormone	MESH:D019004	81668(Tax:10116)	Chemical	Gene	counteracts|nsubj|START_ENTITY counteracts|dobj|effects effects|nmod|glucocorticoids glucocorticoids|nmod|secretion secretion|amod|END_ENTITY	Galanin counteracts the inhibitory effects of glucocorticoids on growth_hormone secretion in the rat .
1707723	0	Galanin	0,7	insulin	17,24	Galanin	insulin	MESH:D019004	3630	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|compound|END_ENTITY	Galanin inhibits insulin and corticosterone release after injection into the PVN .
2430570	0	Galanin	0,7	insulin	36,43	Galanin	insulin	MESH:D019004	3630	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|compound|END_ENTITY	Galanin inhibits glucose-stimulated insulin release by a mechanism involving hyperpolarization and lowering of cytoplasmic free Ca2 + concentration .
7541102	0	Galanin	0,7	neurokinin_A_and_B	39,57	Galanin	neurokinin A and B	MESH:D019004	29191(Tax:10116)	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	Galanin and somatostatin inhibition of neurokinin_A_and_B induced airway mucus secretion in the rat .
1718017	0	Galanin	0,7	pancreatic_amylase	17,35	Galanin	pancreatic amylase	MESH:D019004	497039(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|amod|END_ENTITY	Galanin inhibits pancreatic_amylase secretion in the pentobarbital-anesthetized rat .
12423254	0	Galanin	0,7	tyrosine_hydroxylase	17,37	Galanin	tyrosine hydroxylase	MESH:D019004	25085(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Galanin inhibits tyrosine_hydroxylase expression in midbrain dopaminergic neurons .
2452388	0	Galanin	0,7	vasoactive_intestinal_polypeptide	34,67	Galanin	vasoactive intestinal polypeptide	MESH:D019004	117064(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|nmod|END_ENTITY	Galanin stimulates the release of vasoactive_intestinal_polypeptide from perifused hypothalamic fragments in vitro and from periventricular structures into the cerebrospinal fluid in vivo in the rat .
11172080	0	Galantamine	0,11	acetylcholinesterase	51,71	Galantamine	acetylcholinesterase	MESH:D005702	100009390(Tax:9986)	Chemical	Gene	START_ENTITY|dep|effect effect|amod|inhibition inhibition|amod|END_ENTITY	Galantamine : effect on nicotinic receptor binding , acetylcholinesterase inhibition , and learning .
22669169	0	Galantamine	0,11	acetylcholinesterase	16,36	Galantamine	acetylcholinesterase	MESH:D005702	83817(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Galantamine , an acetylcholinesterase inhibitor and positive allosteric modulator of nicotinic_acetylcholine_receptors , attenuates nicotine taking and seeking in rats .
24972037	0	Galantamine	0,11	acetylcholinesterase	16,36	Galantamine	acetylcholinesterase	MESH:D005702	83817(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Galantamine , an acetylcholinesterase inhibitor , reduces brain_damage induced by hypoxia-ischemia in newborn rats .
22932776	0	Galantamine	0,11	insulin-like_growth_factor_2	34,62	Galantamine	insulin-like growth factor 2	MESH:D005702	16002(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Galantamine increases hippocampal insulin-like_growth_factor_2 expression via a7 nicotinic acetylcholine receptors in mice .
2626444	0	Galanthamine	0,12	acetylcholinesterase	17,37	Galanthamine	acetylcholinesterase	MESH:D005702	11423(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Galanthamine , an acetylcholinesterase inhibitor : a time course of the effects on performance and neurochemical parameters in mice .
20889190	0	Galaxolide	15,25	estrogen_receptor-a	53,72	Galaxolide	estrogen receptor-a	MESH:C033119	2099	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of Galaxolide with the human and trout estrogen_receptor-a .
21328348	0	Galbanic_acid	0,13	androgen_receptor	24,41	Galbanic acid	androgen receptor	MESH:C048972	367	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|END_ENTITY	Galbanic_acid decreases androgen_receptor abundance and signaling and induces G1_arrest in prostate_cancer cells .
24874833	0	Galeterone	0,10	androgen_receptor	20,37	Galeterone	androgen receptor	null	367	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|dobj|END_ENTITY	Galeterone prevents androgen_receptor binding to chromatin and enhances degradation of mutant androgen_receptor .
24755219	0	Galiellalactone	0,15	STAT3	66,71	Galiellalactone	STAT3	MESH:C416043	6774	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Galiellalactone is a direct inhibitor of the transcription factor STAT3 in prostate_cancer cells .
26144873	0	Galiellalactone	20,35	STAT3	4,9	Galiellalactone	STAT3	MESH:C416043	20848(Tax:10090)	Chemical	Gene	Growth|compound|START_ENTITY Growth|compound|END_ENTITY	The STAT3 Inhibitor Galiellalactone Effectively Reduces Tumor Growth and Metastatic Spread in an Orthotopic Xenograft Mouse Model of Prostate_Cancer .
18163422	0	Galiellalactone	0,15	Stat3	113,118	Galiellalactone	Stat3	MESH:C416043	6774	Chemical	Gene	candidate|nsubj|START_ENTITY candidate|nmod|hormone-refractory_prostate_cancer hormone-refractory_prostate_cancer|acl|expressing expressing|dobj|END_ENTITY	Galiellalactone is a novel therapeutic candidate against hormone-refractory_prostate_cancer expressing activated Stat3 .
24722818	0	Gallic_acid	0,11	TRPA1	27,32	Gallic acid	TRPA1	MESH:D005707	277328(Tax:10090)	Chemical	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	Gallic_acid functions as a TRPA1 antagonist with relevant antinociceptive and antiedematogenic effects in mice .
16988841	0	Gallium	0,7	transferrin	18,29	Gallium	transferrin	MESH:D005708	7018	Chemical	Gene	uptake|nsubj|START_ENTITY uptake|nmod|END_ENTITY	Gallium uptake by transferrin and interaction with receptor 1 .
8097242	0	Gallium_arsenide	0,16	CD25	84,88	Gallium arsenide	CD25	MESH:C043055	16184(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|proliferation proliferation|nmod|END_ENTITY	Gallium_arsenide selectively inhibits T cell proliferation and alters expression of CD25 -LRB- IL-2R / p55 -RRB- .
25175164	0	Gamabufotalin	0,13	COX-2	68,73	Gamabufotalin	COX-2	null	17709(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Gamabufotalin , a bufadienolide compound from toad venom , suppresses COX-2 expression through targeting IKKb/NF-kB signaling pathway in lung_cancer cells .
26657289	0	Gamabufotalin	0,13	VEGFR-2	102,109	Gamabufotalin	VEGFR-2	null	16542(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Gamabufotalin , a major derivative of bufadienolide , inhibits VEGF-induced angiogenesis by suppressing VEGFR-2 signaling pathway .
22732400	0	Gambogic_acid	0,13	AMP-activated_protein_kinase	24,52	Gambogic acid	AMP-activated protein kinase	MESH:C052659	5563	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Gambogic_acid activates AMP-activated_protein_kinase in mammalian cells .
23665322	0	Gambogic_acid	0,13	EGFR	22,26	Gambogic acid	EGFR	MESH:C052659	1956	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|degradation degradation|amod|END_ENTITY	Gambogic_acid induces EGFR degradation and Akt/mTORC1 inhibition through AMPK dependent-LRIG1 upregulation in cultured U87 glioma cells .
21074517	0	Gambogic_acid	0,13	Hsp90	23,28	Gambogic acid	Hsp90	MESH:C052659	3320	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Gambogic_acid inhibits Hsp90 and deregulates TNF-a/NF-kB in HeLa cells .
21486005	0	Gambogic_acid	0,13	Hsp90	46,51	Gambogic acid	Hsp90	MESH:C052659	3320	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Gambogic_acid , a natural product inhibitor of Hsp90 .
19821083	0	Gambogic_acid	10,23	hERG	45,49	Gambogic acid	hERG	MESH:C052659	2078	Chemical	Gene	Effect|nmod|START_ENTITY Effect|acl|END_ENTITY	Effect of Gambogic_acid on the regulation of hERG channel in K562 cells in vitro .
25712642	0	Gambogic_amide	0,14	TrkA	39,43	Gambogic amide	TrkA	MESH:C545053	18211(Tax:10090)	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	Gambogic_amide selectively upregulates TrkA expression and triggers its activation .
15763439	0	Gamma-Linolenic_acid	0,20	SPARC	63,68	Gamma-Linolenic acid	SPARC	MESH:D017965	6678	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Gamma-Linolenic_acid regulates the expression and secretion of SPARC in human cancer cells .
12111824	0	Gamma-aminobutyric_acid	0,23	BGT-1	37,42	Gamma-aminobutyric acid	BGT-1	MESH:D005680	6539	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Gamma-aminobutyric_acid transporter -LRB- BGT-1 -RRB- expressed in human astrocytoma U373 MG cells : pharmacological and molecular characterization and phorbol_ester-induced inhibition .
6721733	0	Gamma-aminobutyric_acid	0,23	CSF	67,70	Gamma-aminobutyric acid	CSF	MESH:D005680	1437	Chemical	Gene	concentration|amod|START_ENTITY concentration|nmod|END_ENTITY	Gamma-aminobutyric_acid and homovanillic_acid concentration in the CSF of patients with senile_dementia of Alzheimer 's _ type .
15040890	0	Gamma-aminobutyric_acid	56,79	GAT1	95,99	Gamma-aminobutyric acid	GAT1	MESH:D005680	232333(Tax:10090)	Chemical	Gene	I|amod|START_ENTITY I|appos|END_ENTITY	Impaired reproduction in transgenic_mice overexpressing Gamma-aminobutyric_acid transporter I -LRB- GAT1 -RRB- .
3287209	0	Gamma-aminobutyric_acid	0,23	angiotensin_II_and_renin	70,94	Gamma-aminobutyric acid	angiotensin II and renin	MESH:D005680	24179(Tax:10116)	Chemical	Gene	antagonize|nsubj|START_ENTITY antagonize|dobj|effects effects|nmod|END_ENTITY	Gamma-aminobutyric_acid and taurine antagonize the central effects of angiotensin_II_and_renin on the intake of water and salt , and on blood pressure in rats .
18679050	0	Gamma-aminobutyric_acid	0,23	interleukin-6	45,58	Gamma-aminobutyric acid	interleukin-6	MESH:D005680	24498(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|amod|END_ENTITY	Gamma-aminobutyric_acid inhibits synergistic interleukin-6 release but not transcriptional activation in astrocytoma cells .
19180667	0	Gamma-linolenic_acid	0,20	Ku80	28,32	Gamma-linolenic acid	Ku80	MESH:D017965	363247(Tax:10116)	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|END_ENTITY	Gamma-linolenic_acid alters Ku80 , E2F1 , and bax expression and induces micronucleus formation in C6 glioma cells in vitro .
25534317	0	Gamma-linolenic_acid	0,20	PAI-1	38,43	Gamma-linolenic acid	PAI-1	MESH:D017965	18787(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Gamma-linolenic_acid inhibits hepatic PAI-1 expression by inhibiting p38_MAPK-dependent activator protein and mitochondria-mediated apoptosis pathway .
17114179	0	Gamma-tocotrienol	0,17	nuclear_factor-kappaB	27,48	Gamma-tocotrienol	nuclear factor-kappaB	MESH:C013649	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Gamma-tocotrienol inhibits nuclear_factor-kappaB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis .
7623315	0	Gamma_amino-butyric_acid	0,24	GnRH	44,48	Gamma amino-butyric acid	GnRH	MESH:D005680	443529(Tax:9940)	Chemical	Gene	control|amod|START_ENTITY control|nmod|END_ENTITY	Gamma_amino-butyric_acid and the control of GnRH secretion in sheep .
21544400	0	Gamma_linolenic_acid	0,20	focal_adhesion_kinase	58,79	Gamma linolenic acid	focal adhesion kinase	MESH:D017965	5747	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Gamma_linolenic_acid inhibits tyrosine phosphorylation of focal_adhesion_kinase and paxillin and tumour cell matrix interaction .
21169918	0	Ganciclovir	29,40	ICAM-1	44,50	Ganciclovir	ICAM-1	MESH:D015774	3383	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|compound|END_ENTITY	Direct inhibitory effects of Ganciclovir on ICAM-1 expression and proliferation in human coronary vascular cells -LRB- SI/MPL-ratio : > 1 -RRB- .
22806877	0	Ganetespib	0,10	HSP90	41,46	Ganetespib	HSP90	MESH:C533237	104434(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Ganetespib -LRB- STA-9090 -RRB- , a nongeldanamycin HSP90 inhibitor , has potent antitumor activity in in vitro and in vivo models of non-small_cell_lung_cancer .
26010604	0	Ganetespib	20,30	HSP90	4,9	Ganetespib	HSP90	MESH:C533237	3320	Chemical	Gene	Lung_Adenocarcinoma|compound|START_ENTITY Lung_Adenocarcinoma|compound|END_ENTITY	The HSP90 Inhibitor Ganetespib Radiosensitizes Human Lung_Adenocarcinoma Cells .
26010604	0	Ganetespib	20,30	HSP90	4,9	Ganetespib	HSP90	MESH:C533237	3320	Chemical	Gene	Lung_Adenocarcinoma|compound|START_ENTITY Lung_Adenocarcinoma|compound|END_ENTITY	The HSP90 Inhibitor Ganetespib Radiosensitizes Human Lung_Adenocarcinoma Cells .
22144665	0	Ganetespib	0,10	Hsp90	43,48	Ganetespib	Hsp90	MESH:C533237	3320	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Ganetespib , a unique triazolone-containing Hsp90 inhibitor , exhibits potent antitumor activity and a superior safety profile for cancer therapy .
25444464	0	Ganetespib	0,10	Hsp90	20,25	Ganetespib	Hsp90	MESH:C533237	3320	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|compound|END_ENTITY	Ganetespib , a Novel Hsp90 Inhibitor in Patients With KRAS Mutated and Wild Type , Refractory Metastatic Colorectal_Cancer .
8549425	0	Ganglioside	0,11	GD3	20,23	Ganglioside	GD3	CHEBI:28892	117189	Chemical	Gene	markers|nsubj|START_ENTITY markers|dobj|END_ENTITY	Ganglioside markers GD3 , GD2 , and A2B5 in fetal human neurons and glial cells in culture .
11168800	0	Ganglioside	0,11	epidermal_growth_factor_receptor	44,76	Ganglioside	epidermal growth factor receptor	CHEBI:28892	1956	Chemical	Gene	modulates|amod|START_ENTITY ligand|nsubj|modulates ligand|xcomp|binding binding|nmod|END_ENTITY	Ganglioside modulates ligand binding to the epidermal_growth_factor_receptor .
12354760	0	Ganglioside	0,11	epidermal_growth_factor_receptor	71,103	Ganglioside	epidermal growth factor receptor	CHEBI:28892	1956	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Ganglioside induces caveolin-1 redistribution and interaction with the epidermal_growth_factor_receptor .
2150416	0	Ganglioside	0,11	plasmin	33,40	Ganglioside	plasmin	CHEBI:28892	5340	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|dep|END_ENTITY	Ganglioside inhibition of -LRB- 125I -RRB- - plasmin binding to colorectal_carcinoma cells .
20663960	0	Ganglioside_DSGb5	0,17	Siglec-7	40,48	Ganglioside DSGb5	Siglec-7	null	27036	Chemical	Gene	START_ENTITY|appos|ligand ligand|nmod|END_ENTITY	Ganglioside_DSGb5 , preferred ligand for Siglec-7 , inhibits NK cell cytotoxicity against renal_cell_carcinoma cells .
9202301	0	Ganglioside_GM1	0,15	Erk2	63,67	Ganglioside GM1	Erk2	MESH:D005677	5594	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Ganglioside_GM1 activates the mitogen-activated protein kinase Erk2 and p70_S6_kinase in U-1242 MG human glioma cells .
22331905	0	Ganglioside_GM1	0,15	huntingtin	50,60	Ganglioside GM1	huntingtin	MESH:D005677	15194(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Ganglioside_GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington_disease mice .
14512423	0	Ganglioside_GM3	0,15	epidermal_growth_factor_receptor	41,73	Ganglioside GM3	epidermal growth factor receptor	MESH:D005679	1956	Chemical	Gene	blocks|nsubj|START_ENTITY blocks|dobj|activation activation|nmod|END_ENTITY	Ganglioside_GM3 blocks the activation of epidermal_growth_factor_receptor induced by integrin at specific tyrosine sites .
12724312	0	Ganglioside_GM3	0,15	matrix_metalloproteinase-9	25,51	Ganglioside GM3	matrix metalloproteinase-9	MESH:D005679	4318	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	Ganglioside_GM3 inhibits matrix_metalloproteinase-9 activation and disrupts its association with integrin .
1827496	0	Gangliosides	0,12	glucosylceramide_synthase	21,46	Gangliosides	glucosylceramide synthase	MESH:D005732	22234(Tax:10090)	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|END_ENTITY	Gangliosides inhibit glucosylceramide_synthase : a possible role in ganglioside therapy .
11859933	0	Gangliosides	0,12	interleukin-1beta	36,53	Gangliosides	interleukin-1beta	MESH:D005732	3553	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|release release|nmod|cells cells|amod|END_ENTITY	Gangliosides inhibit the release of interleukin-1beta in amyloid beta-protein-treated human monocytic cells .
7751022	0	Gangliosides	0,12	interleukin-4	27,40	Gangliosides	interleukin-4	MESH:D005732	16189(Tax:10090)	Chemical	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	Gangliosides interact with interleukin-4 and inhibit interleukin-4-stimulated helper T-cell proliferation .
9091332	0	Ganirelix	122,131	gonadotropin-releasing_hormone	79,109	Ganirelix	gonadotropin-releasing hormone	MESH:C061018	2796	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Dose-related suppression of serum luteinizing hormone in women by a potent new gonadotropin-releasing_hormone antagonist -LRB- Ganirelix -RRB- administered by intranasal spray .
26400206	0	Garcinol	0,8	Notch1	23,29	Garcinol	Notch1	MESH:C054597	4851	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	Garcinol downregulates Notch1 signaling via modulating miR-200c and suppresses oncogenic properties of PANC-1 cancer stem-like cells .
25955534	0	Gartanin	0,8	JNK	35,38	Gartanin	JNK	null	5599	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|compound|END_ENTITY	Gartanin induces autophagy through JNK activation which extenuates caspase-dependent apoptosis .
6674915	0	Gastric_acid	0,12	gastrin	23,30	Gastric acid	gastrin	null	2520	Chemical	Gene	START_ENTITY|dobj|response response|compound|END_ENTITY	Gastric_acid and serum gastrin response to sham feeding , and the effect of cimetidine on the response to sham feeding in duodenal ulcer patients .
6771180	0	Gastric_acid	0,12	gastrin	75,82	Gastric acid	gastrin	null	2520	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Gastric_acid and pepsin-stimulating activity of non-sulphated fragments of gastrin in the cat .
7075932	0	Gastric_acid	0,12	gastrin	30,37	Gastric acid	gastrin	null	2520	Chemical	Gene	secretion|amod|START_ENTITY secretion|appos|END_ENTITY	Gastric_acid secretion , serum gastrin and parietal cell histology in hyperthyroidism .
7075933	0	Gastric_acid	0,12	gastrin	30,37	Gastric acid	gastrin	null	25320(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY secretion|appos|END_ENTITY	Gastric_acid secretion , serum gastrin and parietal cell histology in rat hyperthyroidism .
7101324	0	Gastric_acid	0,12	gastrin	34,41	Gastric acid	gastrin	null	2520	Chemical	Gene	START_ENTITY|dobj|response response|compound|END_ENTITY	Gastric_acid secretion and plasma gastrin response to test meal in patients with gastric_cancer .
7227767	0	Gastric_acid	0,12	gastrin	33,40	Gastric acid	gastrin	null	2520	Chemical	Gene	START_ENTITY|dobj|levels levels|compound|END_ENTITY	Gastric_acid secretion and serum gastrin levels in chronic_pancreatitis .
769199	0	Gastric_acid	0,12	gastrin	23,30	Gastric acid	gastrin	null	2520	Chemical	Gene	START_ENTITY|dobj|secretion secretion|compound|END_ENTITY	Gastric_acid and serum gastrin secretion before and after bypass of the small intestine for morbid obesity .
6814927	0	Gastric_acid	0,12	secretin	45,53	Gastric acid	secretin	null	6343	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|release release|nmod|END_ENTITY	Gastric_acid regulates the release of plasma secretin in man .
26987953	0	Gastrodin	0,9	BACE1	21,26	Gastrodin	BACE1	MESH:C045345	23821(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Gastrodin suppresses BACE1 expression under oxidative stress condition via inhibition of the PKR/eIF2a pathway in Alzheimer 's _ disease .
23783886	0	Gastrodin	0,9	connexin_43	60,71	Gastrodin	connexin 43	MESH:C045345	2697	Chemical	Gene	ameliorates|nsubj|START_ENTITY ameliorates|nmod|END_ENTITY	Gastrodin ameliorates Parkinson 's _ disease by downregulating connexin_43 .
17727838	0	Gatifloxacin	0,12	GLUT1	21,26	Gatifloxacin	GLUT1	MESH:C078049	6513	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|expression expression|nummod|END_ENTITY	Gatifloxacin affects GLUT1 gene expression and disturbs glucose homeostasis in vitro .
18816111	0	Gedunin	0,7	hsp90	17,22	Gedunin	hsp90	MESH:C106014	3320	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Gedunin , a novel hsp90 inhibitor : semisynthesis of derivatives and preliminary structure-activity relationships .
24457609	0	Gefitinib	0,9	ABCG2	87,92	Gefitinib	ABCG2	MESH:C419708	9429	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|advcl|inhibiting inhibiting|dobj|END_ENTITY	Gefitinib enhances the antitumor activity of CPT-11 in vitro and in vivo by inhibiting ABCG2 but not ABCB1 : a new clue to circumvent gastrointestinal_toxicity risk .
24965408	0	Gefitinib	0,9	AMPK	74,78	Gefitinib	AMPK	MESH:C419708	5563	Chemical	Gene	activates|nsubj|START_ENTITY activates|nmod|END_ENTITY	Gefitinib , an EGFR tyrosine kinase inhibitor , activates autophagy through AMPK in human lung_cancer cells .
16229013	0	Gefitinib	0,9	Bax	95,98	Gefitinib	Bax	MESH:C419708	581	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Gefitinib , a selective EGFR tyrosine kinase inhibitor , induces apoptosis through activation of Bax in human gallbladder_adenocarcinoma cells .
15660382	0	Gefitinib	0,9	EGFR	14,18	Gefitinib	EGFR	MESH:C419708	24329(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Gefitinib , an EGFR inhibitor , prevents hepatocellular_carcinoma development in the rat liver with cirrhosis .
16229013	0	Gefitinib	0,9	EGFR	23,27	Gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Gefitinib , a selective EGFR tyrosine kinase inhibitor , induces apoptosis through activation of Bax in human gallbladder_adenocarcinoma cells .
16407879	0	Gefitinib	0,9	EGFR	83,87	Gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	response|amod|START_ENTITY response|dep|role role|nmod|mutation mutation|amod|END_ENTITY	Gefitinib response of erlotinib-refractory lung cancer involving meninges -- role of EGFR mutation .
17203166	0	Gefitinib	0,9	EGFR	91,95	Gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|mutation mutation|amod|END_ENTITY	Gefitinib induces premature senescence in non-small_cell_lung_cancer cells with or without EGFR gene mutation .
19201048	0	Gefitinib	108,117	EGFR	17,21	Gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	treated|nmod|START_ENTITY patients|acl|treated predict|nmod|patients predict|nsubj|Polymorphisms Polymorphisms|nmod|END_ENTITY	Polymorphisms of EGFR predict clinical outcome in advanced non-small-cell_lung_cancer patients treated with Gefitinib .
20088784	0	Gefitinib	0,9	EGFR	18,22	Gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	targets|nsubj|START_ENTITY targets|dobj|dimerization dimerization|amod|END_ENTITY	Gefitinib targets EGFR dimerization and ERK1/2 phosphorylation to inhibit pleural_mesothelioma cell proliferation .
21274259	0	Gefitinib	80,89	EGFR	14,18	Gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	Treated|nmod|START_ENTITY Screening|nmod|Treated Screening|nmod|Mutations Mutations|compound|END_ENTITY	Screening for EGFR Mutations in Patients with Head_and_Neck_Cancer Treated with Gefitinib on a Compassionate-Use Program : A Hellenic Cooperative Oncology Group Study .
21512416	0	Gefitinib	0,9	EGFR	133,137	Gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	START_ENTITY|advcl|testing testing|nmod|mutations mutations|appos|END_ENTITY	Gefitinib therapy in patients with advanced non-small_cell_lung_cancer with or without testing for epidermal_growth_factor_receptor -LRB- EGFR -RRB- mutations .
21859544	0	Gefitinib	70,79	EGFR	37,41	Gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of rs2293347 Polymorphism in EGFR on the Clinical Efficacy of Gefitinib in Patients with Non-small_Cell_Lung_Cancer -RSB- .
21875483	0	Gefitinib	70,79	EGFR	22,26	Gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	efficacy|nmod|START_ENTITY END_ENTITY|nmod|efficacy	-LSB- Association of serum EGFR protein concentration with the efficacy of Gefitinib in the treatment of advanced non-small_cell_lung_cancer -RSB- .
22449680	0	Gefitinib	0,9	EGFR	99,103	Gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	START_ENTITY|nmod|squamous_cell_carcinoma squamous_cell_carcinoma|nmod|lung lung|acl|harboring harboring|dobj|mutation mutation|amod|END_ENTITY	Gefitinib for a poor performance status patient with squamous_cell_carcinoma of the lung harboring EGFR mutation .
22963131	1	Gefitinib	174,183	EGFR	365,369	Gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	treatment|nsubj|START_ENTITY treatment|nmod|patients patients|appos|END_ENTITY	BACKGROUND : Gefitinib , a tyrosine kinase inhibitor , is an effective treatment in advanced non-small_cell_lung_cancer -LRB- NSCLC -RRB- patients with an activating mutation in the epidermal_growth_factor_receptor -LRB- EGFR -RRB- .
23313300	0	Gefitinib	84,93	EGFR	8,12	Gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|Role Role|nmod|SNPs SNPs|compound|END_ENTITY	Role of EGFR SNPs in survival of advanced lung_adenocarcinoma patients treated with Gefitinib .
23548963	0	Gefitinib	100,109	EGFR	16,20	Gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	Analysis|nmod|START_ENTITY Analysis|nmod|status status|amod|END_ENTITY	Analysis of the EGFR mutation status in head_and_neck_squamous_cell_carcinoma before treatment with Gefitinib .
24492164	0	Gefitinib	5,14	EGFR	31,35	Gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	Effects|nsubj|START_ENTITY Effects|nmod|Thymoma Thymoma|compound|END_ENTITY	Does Gefitinib Have Effects on EGFR Mutation-Positive Thymoma ?
25122430	0	Gefitinib	0,9	EGFR	116,120	Gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	treatment|amod|START_ENTITY treatment|dep|DNA DNA|nmod|surrogate surrogate|nmod|determination determination|nmod|status status|amod|END_ENTITY	Gefitinib treatment in EGFR mutated caucasian NSCLC : circulating-free tumor DNA as a surrogate for determination of EGFR status .
25122430	0	Gefitinib	0,9	EGFR	23,27	Gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|NSCLC NSCLC|compound|END_ENTITY	Gefitinib treatment in EGFR mutated caucasian NSCLC : circulating-free tumor DNA as a surrogate for determination of EGFR status .
25591596	0	Gefitinib	0,9	EGFR	90,94	Gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	therapy|amod|START_ENTITY therapy|nmod|patients patients|nmod|mutations mutations|amod|END_ENTITY	Gefitinib maintenance therapy in Chinese advanced-stage_lung_adenocarcinoma patients with EGFR mutations treated with prior chemotherapy .
25695221	0	Gefitinib	18,27	EGFR	138,142	Gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	START_ENTITY|nmod|Combination Combination|nmod|Bevacizumab Bevacizumab|nmod|Therapy Therapy|nmod|Lung_Cancer Lung_Cancer|nmod|Mutations Mutations|compound|END_ENTITY	Phase II Trial of Gefitinib in Combination with Bevacizumab as First-Line Therapy for Advanced Non-Small Cell Lung_Cancer with Activating EGFR Gene Mutations : The Okayama Lung_Cancer Study Group Trial 1001 .
25795832	0	Gefitinib	61,70	EGFR	105,109	Gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	START_ENTITY|nmod|Enriched Enriched|nmod|Mutation Mutation|compound|END_ENTITY	P1 .12 A Phase I Dose Defining Study for MK-2206 Combined with Gefitinib in NSCLC Population Enriched with EGFR Mutation .
25818798	0	Gefitinib	1,10	EGFR	79,83	Gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Gefitinib versus Erlotinib as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell_lung_cancer -RSB- .
26001153	0	Gefitinib	39,48	EGFR	9,13	Gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	Resistance|compound|START_ENTITY Exon|dep|Resistance Exon|compound|END_ENTITY	Uncommon EGFR Exon 19 Mutations Confer Gefitinib Resistance in Advanced Lung_Adenocarcinoma .
26001153	0	Gefitinib	39,48	EGFR	9,13	Gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	Resistance|compound|START_ENTITY Exon|dep|Resistance Exon|compound|END_ENTITY	Uncommon EGFR Exon 19 Mutations Confer Gefitinib Resistance in Advanced Lung_Adenocarcinoma .
26200273	0	Gefitinib	68,77	EGFR	133,137	Gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	Outcomes|compound|START_ENTITY Outcomes|nmod|Cancer Cancer|nmod|Mutation Mutation|compound|END_ENTITY	Total Lesion Glycolysis in Positron Emission Tomography Can Predict Gefitinib Outcomes in Non-Small-Cell Lung Cancer with Activating EGFR Mutation .
26200273	0	Gefitinib	68,77	EGFR	133,137	Gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	Outcomes|compound|START_ENTITY Outcomes|nmod|Cancer Cancer|nmod|Mutation Mutation|compound|END_ENTITY	Total Lesion Glycolysis in Positron Emission Tomography Can Predict Gefitinib Outcomes in Non-Small-Cell Lung Cancer with Activating EGFR Mutation .
26228025	0	Gefitinib	20,29	EGFR	95,99	Gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	Concentration|compound|START_ENTITY Dissociation|nmod|Concentration Dissociation|nmod|Mutations Mutations|compound|END_ENTITY	The Dissociation of Gefitinib Trough Concentration and Clinical Outcome in NSCLC Patients with EGFR Sensitive Mutations .
26571844	0	Gefitinib	1,10	EGFR	75,79	Gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	therapy|compound|START_ENTITY therapy|nmod|lung_cancer lung_cancer|nmod|patients patients|nmod|mutations mutations|amod|END_ENTITY	-LSB- Gefitinib therapy in advanced non-small cell lung_cancer in patients with EGFR mutations : cost-effectiveness analysis -RSB- .
26967328	0	Gefitinib	85,94	EGFR	0,4	Gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	Therapy|compound|START_ENTITY Associated|dep|Therapy Associated|nsubj|Deletion Deletion|compound|END_ENTITY	EGFR Exon 19 Deletion is Associated With Favorable Overall Survival After First-line Gefitinib Therapy in Advanced Non-Small_Cell_Lung_Cancer Patients .
26980062	0	Gefitinib	16,25	EGFR	72,76	Gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	Approval|nmod|START_ENTITY Approval|nmod|Patients Patients|nmod|Non-Small_Cell_Lung_Cancer Non-Small_Cell_Lung_Cancer|compound|END_ENTITY	FDA Approval of Gefitinib for the Treatment of Patients with Metastatic EGFR Mutation-Positive Non-Small_Cell_Lung_Cancer .
27006151	0	Gefitinib	15,24	EGFR	112,116	Gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	Combination|nmod|START_ENTITY prevents|nsubj|Combination prevents|advcl|carrying carrying|dobj|mutation mutation|amod|END_ENTITY	Combination of Gefitinib and Pemetrexed prevents the acquisition of TKI-resistance in NSCLC cell lines carrying EGFR activating mutation .
27073548	0	Gefitinib	0,9	EGFR	59,63	Gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	START_ENTITY|nmod|therapy therapy|nmod|patients patients|nmod|non-small-cell_lung_cancer non-small-cell_lung_cancer|amod|END_ENTITY	Gefitinib as first line therapy in Malaysian patients with EGFR mutation-positive non-small-cell_lung_cancer : A single-center retrospective study .
26532507	0	Gefitinib	33,42	Egfr	97,101	Gefitinib	Egfr	MESH:C419708	1956	Chemical	Gene	Analysis|nmod|START_ENTITY Analysis|nmod|Mutation Mutation|compound|END_ENTITY	A Cost-Effectiveness Analysis of Gefitinib as the First Line Treatment in Patients With Positive Egfr Mutation In Metastatic or Locally Advanced non-Small Cell .
21216488	0	Gefitinib	0,9	Epidermal_Growth_Factor_Receptor	104,136	Gefitinib	Epidermal Growth Factor Receptor	MESH:C419708	1956	Chemical	Gene	START_ENTITY|nmod|treatment treatment|nmod|patients patients|nmod|lung_cancer lung_cancer|nmod|mutation mutation|compound|END_ENTITY	Gefitinib as first-line treatment for patients with advanced non-small-cell lung_cancer with activating Epidermal_Growth_Factor_Receptor mutation : implications for clinical practice and open issues .
24707260	0	Gefitinib	190,199	Epidermal_Growth_Factor_Receptor	108,140	Gefitinib	Epidermal Growth Factor Receptor	MESH:C419708	1956	Chemical	Gene	Treatment|compound|START_ENTITY Resected|nmod|Treatment Resected|nmod|Image Image|nmod|Harboring Harboring|dep|Mutation Mutation|compound|END_ENTITY	Discrepancy between the Clinical Image and Pathological Findings of Non-Small_Cell_Lung_Cancer Harboring an Epidermal_Growth_Factor_Receptor Gene Mutation That Was Surgically Resected after Gefitinib Treatment .
25979647	0	Gefitinib	63,72	Epidermal_Growth_Factor_Receptor	90,122	Gefitinib	Epidermal Growth Factor Receptor	MESH:C419708	1956	Chemical	Gene	Overcomes|nmod|START_ENTITY Overcomes|nmod|Cells Cells|compound|END_ENTITY	Autophagy Inhibition Overcomes the Antagonistic Effect Between Gefitinib and Cisplatin in Epidermal_Growth_Factor_Receptor Mutant Non-Small-Cell Lung_Cancer Cells .
26288223	0	Gefitinib	0,9	Epidermal_Growth_Factor_Receptor	103,135	Gefitinib	Epidermal Growth Factor Receptor	MESH:C419708	1956	Chemical	Gene	Lead|nsubj|START_ENTITY Lead|nmod|Phosphorylation Phosphorylation|nmod|END_ENTITY	Gefitinib and Erlotinib Lead to Phosphorylation of Eukaryotic Initiation Factor 2 Alpha Independent of Epidermal_Growth_Factor_Receptor in A549 Cells .
26335629	0	Gefitinib	45,54	Epidermal_Growth_Factor_Receptor	120,152	Gefitinib	Epidermal Growth Factor Receptor	MESH:C419708	1956	Chemical	Gene	Impact|nmod|START_ENTITY Impact|nmod|Patients Patients|nmod|Mutations Mutations|compound|END_ENTITY	Impact of Smoking History on the Efficacy of Gefitinib in Patients with Non-Small_Cell_Lung_Cancer Harboring Activating Epidermal_Growth_Factor_Receptor Mutations .
25593344	0	Gefitinib	54,63	HDAC1	28,33	Gefitinib	HDAC1	MESH:C419708	3065	Chemical	Gene	Sensitivity|compound|START_ENTITY Sensitivity|compound|END_ENTITY	DUSP1 Expression Induced by HDAC1 Inhibition Mediates Gefitinib Sensitivity in Non-Small_Cell_Lung_Cancers .
21177177	0	Gefitinib	1,10	a-smooth_muscle_actin	20,41	Gefitinib	a-smooth muscle actin	MESH:C419708	11475(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	-LSB- Gefitinib inhibits a-smooth_muscle_actin expression in mice with bleomycin-induced lung_fibrosis -RSB- .
26170696	0	Gefitinib	0,9	death_receptor_5	22,38	Gefitinib	death receptor 5	MESH:C419708	8795	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Gefitinib upregulates death_receptor_5 expression to mediate rmhTRAIL-induced apoptosis in Gefitinib-sensitive NSCLC cell line .
14607328	0	Gefitinib	0,9	epidermal_growth_factor_receptor	25,57	Gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Gefitinib -LRB- ` Iressa ' -RRB- , an epidermal_growth_factor_receptor tyrosine kinase inhibitor , mediates the inhibition of lymph node metastasis in oral_cancer cells .
14662414	0	Gefitinib	0,9	epidermal_growth_factor_receptor	33,65	Gefitinib	epidermal growth factor receptor	MESH:C419708	13649(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Gefitinib -LRB- ` Iressa ' , ZD1839 -RRB- , an epidermal_growth_factor_receptor tyrosine kinase inhibitor , up-regulates p27KIP1 and induces G1_arrest in oral_squamous_cell_carcinoma cell lines .
15735043	0	Gefitinib	0,9	epidermal_growth_factor_receptor	33,65	Gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Gefitinib -LRB- `` Iressa '' , ZD1839 -RRB- , an epidermal_growth_factor_receptor tyrosine kinase inhibitor , reverses breast_cancer_resistance_protein / ABCG2-mediated drug resistance .
15753373	0	Gefitinib	128,137	epidermal_growth_factor_receptor	69,101	Gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	ZD1839|dep|START_ENTITY Iressa|appos|ZD1839 Multidrug|nsubj|Iressa Multidrug|dep|prevents prevents|dobj|death death|acl|induced induced|nmod|inhibitor inhibitor|compound|END_ENTITY	Multidrug transporter ABCG2 prevents tumor cell death induced by the epidermal_growth_factor_receptor inhibitor Iressa -LRB- ZD1839 , Gefitinib -RRB- .
16288045	0	Gefitinib	129,138	epidermal_growth_factor_receptor	19,51	Gefitinib	epidermal growth factor receptor	MESH:C419708	13649(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY defines|nmod|effect defines|nsubj|Uncoupling Uncoupling|nmod|signals signals|compound|END_ENTITY	Uncoupling between epidermal_growth_factor_receptor and downstream signals defines resistance to the antiproliferative effect of Gefitinib in bladder_cancer cells .
16508686	0	Gefitinib	0,9	epidermal_growth_factor_receptor	14,46	Gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	START_ENTITY|appos|agent agent|compound|END_ENTITY	Gefitinib , an epidermal_growth_factor_receptor blockade agent , shows additional or synergistic effects on the radiosensitivity of esophageal_cancer cells in vitro .
16568376	0	Gefitinib	0,9	epidermal_growth_factor_receptor	69,101	Gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	pathways|nsubj|START_ENTITY pathways|dobj|downstream downstream|nmod|END_ENTITY	Gefitinib and the modulation of the signaling pathways downstream of epidermal_growth_factor_receptor in human liver_cancer cells .
16675591	0	Gefitinib	0,9	epidermal_growth_factor_receptor	140,172	Gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|growth growth|acl:relcl|dependent dependent|nmod|activation activation|compound|END_ENTITY	Gefitinib inhibits the growth and invasion of urothelial_carcinoma cell lines in which Akt and MAPK activation is dependent on constitutive epidermal_growth_factor_receptor activation .
17106442	0	Gefitinib	0,9	epidermal_growth_factor_receptor	55,87	Gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	START_ENTITY|nmod|mutations mutations|compound|END_ENTITY	Gefitinib for non-small-cell_lung_cancer patients with epidermal_growth_factor_receptor gene mutations screened by peptide nucleic acid-locked nucleic acid PCR clamp .
17597605	0	Gefitinib	177,186	epidermal_growth_factor_receptor	4,36	Gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	treated|nmod|START_ENTITY advanced_lung_cancer|acl|treated patients|nmod|advanced_lung_cancer outcome|nmod|patients predictor|nmod|outcome n|ccomp|predictor n|nsubj|intron1 intron1|compound|END_ENTITY	The epidermal_growth_factor_receptor intron1 -LRB- CA -RRB- n microsatellite polymorphism is a potential predictor of treatment outcome in patients with advanced_lung_cancer treated with Gefitinib .
17902048	0	Gefitinib	145,154	epidermal_growth_factor_receptor	44,76	Gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	response|compound|START_ENTITY implication|nmod|response involvement|dep|implication involvement|nmod|END_ENTITY	Insulin_receptor_substrate-1 involvement in epidermal_growth_factor_receptor and insulin-like growth factor receptor signalling : implication for Gefitinib -LRB- ` Iressa ' -RRB- response and resistance .
18377894	0	Gefitinib	133,142	epidermal_growth_factor_receptor	89,121	Gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	The role of repair protein Rad51 in synergistic cytotoxicity and mutagenicity induced by epidermal_growth_factor_receptor inhibitor -LRB- Gefitinib , IressaR -RRB- and benzo -LSB- a -RSB- pyrene in human lung_cancer .
20022809	0	Gefitinib	0,9	epidermal_growth_factor_receptor	114,146	Gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	docetaxel|compound|START_ENTITY docetaxel|nmod|patients patients|nmod|mutations mutations|nmod|END_ENTITY	Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung_cancer harbouring mutations of the epidermal_growth_factor_receptor -LRB- WJTOG3405 -RRB- : an open label , randomised phase 3 trial .
21216486	0	Gefitinib	0,9	epidermal_growth_factor_receptor	104,136	Gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	START_ENTITY|nmod|treatment treatment|nmod|patients patients|nmod|non-small-cell_lung_cancer non-small-cell_lung_cancer|nmod|mutation mutation|compound|END_ENTITY	Gefitinib as first-line treatment for patients with advanced non-small-cell_lung_cancer with activating epidermal_growth_factor_receptor mutation : Review of the evidence .
21512416	0	Gefitinib	0,9	epidermal_growth_factor_receptor	99,131	Gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	START_ENTITY|advcl|testing testing|nmod|mutations mutations|amod|END_ENTITY	Gefitinib therapy in patients with advanced non-small_cell_lung_cancer with or without testing for epidermal_growth_factor_receptor -LRB- EGFR -RRB- mutations .
21931838	0	Gefitinib	0,9	epidermal_growth_factor_receptor	18,50	Gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|dimers dimers|compound|END_ENTITY	Gefitinib induces epidermal_growth_factor_receptor dimers which alters the interaction characteristics with I-EGF .
22659964	0	Gefitinib	0,9	epidermal_growth_factor_receptor	122,154	Gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|cytotoxicities cytotoxicities|nmod|agents agents|nmod|cells cells|acl|exhibiting exhibiting|dobj|mutation mutation|compound|END_ENTITY	Gefitinib enhances cytotoxicities of antimicrotubule agents in non-small-cell_lung_cancer cells exhibiting no sensitizing epidermal_growth_factor_receptor mutation .
23849826	0	Gefitinib	136,145	epidermal_growth_factor_receptor	12,44	Gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	signalling|nmod|START_ENTITY factor-mediated|xcomp|signalling growth|acl|factor-mediated inhibition|nmod|growth expression|dep|inhibition expression|compound|END_ENTITY	Evidence of epidermal_growth_factor_receptor expression in uveal_melanoma : inhibition of epidermal growth factor-mediated signalling by Gefitinib and Cetuximab triggered antibody-dependent_cellular_cytotoxicity .
25953679	0	Gefitinib	0,9	epidermal_growth_factor_receptor	98,130	Gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	treatment|amod|START_ENTITY lung_cancer|nsubj|treatment lung_cancer|xcomp|harboring harboring|dobj|mutations mutations|compound|END_ENTITY	Gefitinib treatment in patients with postoperative recurrent non-small-cell lung_cancer harboring epidermal_growth_factor_receptor gene mutations .
25228008	0	Gefitinib	0,9	p27	65,68	Gefitinib	p27	MESH:C419708	10671	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|translocation translocation|nmod|END_ENTITY	Gefitinib induces cytoplasmic translocation of the CDK inhibitor p27 and its binding to a cleaved intermediate of caspase_8 in non-small_cell_lung_cancer cells .
14662414	0	Gefitinib	0,9	p27KIP1	106,113	Gefitinib	p27KIP1	MESH:C419708	12576(Tax:10090)	Chemical	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|END_ENTITY	Gefitinib -LRB- ` Iressa ' , ZD1839 -RRB- , an epidermal_growth_factor_receptor tyrosine kinase inhibitor , up-regulates p27KIP1 and induces G1_arrest in oral_squamous_cell_carcinoma cell lines .
22371501	0	Gekko-sulfated_glycopeptide	0,27	basic_fibroblast_growth_factor	69,99	Gekko-sulfated glycopeptide	basic fibroblast growth factor	null	14173(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	Gekko-sulfated_glycopeptide inhibits tumor angiogenesis by targeting basic_fibroblast_growth_factor .
11280726	0	Geldanamycin	0,12	Bcr-Abl	76,83	Geldanamycin	Bcr-Abl	MESH:C001277	25	Chemical	Gene	lowers|nsubj|START_ENTITY lowers|dobj|levels levels|amod|END_ENTITY	Geldanamycin and its analogue 17-allylamino-17-demethoxygeldanamycin lowers Bcr-Abl levels and induces apoptosis and differentiation of Bcr-Abl-positive human leukemic_blasts .
17324379	0	Geldanamycin	0,12	Cdc2	85,89	Geldanamycin	Cdc2	MESH:C001277	983	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|downregulation downregulation|nmod|END_ENTITY	Geldanamycin induces G2_arrest in U87MG glioblastoma cells through downregulation of Cdc2 and cyclin_B1 .
10632574	0	Geldanamycin	0,12	HSF1	73,77	Geldanamycin	HSF1	MESH:C001277	3297	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Geldanamycin induces heat_shock protein expression through activation of HSF1 in K562 erythroleukemic cells .
15090481	0	Geldanamycin	0,12	HSP70	139,144	Geldanamycin	HSP70	MESH:C001277	15511(Tax:10090)	Chemical	Gene	treatment|compound|START_ENTITY inhibits|nsubj|treatment inhibits|parataxis|role role|nmod|END_ENTITY	Geldanamycin treatment inhibits hemorrhage-induced increases in KLF6 and iNOS expression in unresuscitated mouse organs : role of inducible HSP70 .
16565416	0	Geldanamycin	0,12	HSP70	78,83	Geldanamycin	HSP70	MESH:C001277	15511(Tax:10090)	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|advcl|overexpressing overexpressing|dobj|END_ENTITY	Geldanamycin prevents hemorrhage-induced ATP loss by overexpressing inducible HSP70 and activating pyruvate dehydrogenase .
18534054	0	Geldanamycin	0,12	HSP70	58,63	Geldanamycin	HSP70	MESH:C001277	266759(Tax:10116)	Chemical	Gene	protects|nsubj|START_ENTITY protects|xcomp|rat rat|nmod|overexpression overexpression|nmod|END_ENTITY	Geldanamycin protects rat brain through overexpression of HSP70 and reducing brain_edema after cerebral_focal_ischemia .
14999769	0	Geldanamycin	0,12	HSP90	56,61	Geldanamycin	HSP90	MESH:C001277	3320	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|activity activity|nmod|END_ENTITY	Geldanamycin , an inhibitor of the chaperone activity of HSP90 , induces MAPK-independent cell cycle arrest .
17870069	0	Geldanamycin	0,12	HSP90	16,21	Geldanamycin	HSP90	MESH:C001277	3320	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Geldanamycin , a HSP90 inhibitor , attenuates the hypoxia-induced vascular_endothelial_growth_factor expression in retinal pigment epithelium cells in vitro .
15358157	0	Geldanamycin	0,12	Hsp70	21,26	Geldanamycin	Hsp70	MESH:C001277	3308	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Geldanamycin induces Hsp70 and prevents alpha-synuclein aggregation and toxicity in vitro .
15950770	0	Geldanamycin	0,12	Hsp70	23,28	Geldanamycin	Hsp70	MESH:C001277	3308	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|response response|amod|END_ENTITY	Geldanamycin activates Hsp70 response and attenuates okadaic_acid-induced cytotoxicity in human retinal pigment epithelial cells .
19995547	0	Geldanamycin	0,12	Hsp70	62,67	Geldanamycin	Hsp70	MESH:C001277	3308	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|TGF-beta TGF-beta|acl|signaling signaling|nmod|induction induction|nmod|END_ENTITY	Geldanamycin inhibits TGF-beta signaling through induction of Hsp70 .
14713575	0	Geldanamycin	0,12	Hsp90	30,35	Geldanamycin	Hsp90	MESH:C001277	3320	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Geldanamycin , an inhibitor of Hsp90 , sensitizes human tumour cells to radiation .
16513847	0	Geldanamycin	0,12	Hsp90	30,35	Geldanamycin	Hsp90	MESH:C001277	3320	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Geldanamycin , an inhibitor of Hsp90 , potentiates cytochrome P4502E1-mediated toxicity in HepG2 cells .
17233535	0	Geldanamycin	0,12	Hsp90	30,35	Geldanamycin	Hsp90	MESH:C001277	3320	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Geldanamycin , an inhibitor of Hsp90 , blocks cytoplasmic retention of progesterone receptors and glucocorticoid receptors via their respective ligand binding domains .
17382893	0	Geldanamycin	0,12	Hsp90	30,35	Geldanamycin	Hsp90	MESH:C001277	3320	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Geldanamycin , an inhibitor of Hsp90 increases cytochrome_P450_2E1 mediated toxicity in HepG2 cells through sustained activation of the p38MAPK pathway .
12471618	0	Geldanamycin	0,12	Raf-1	23,28	Geldanamycin	Raf-1	MESH:C001277	5894	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|levels levels|amod|END_ENTITY	Geldanamycin decreases Raf-1 and Akt levels and induces apoptosis in neuroblastomas .
19995547	0	Geldanamycin	0,12	TGF-beta	22,30	Geldanamycin	TGF-beta	MESH:C001277	7040	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Geldanamycin inhibits TGF-beta signaling through induction of Hsp70 .
11245482	0	Geldanamycin	0,12	beta-catenin	67,79	Geldanamycin	beta-catenin	MESH:C001277	1499	Chemical	Gene	abrogates|nsubj|START_ENTITY abrogates|nmod|END_ENTITY	Geldanamycin abrogates ErbB2 association with proteasome-resistant beta-catenin in melanoma cells , increases beta-catenin-E-cadherin association , and decreases beta-catenin-sensitive transcription .
9201920	0	Geldanamycin	0,12	glucocorticoid_receptor	118,141	Geldanamycin	glucocorticoid receptor	MESH:C001277	2908	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|translocation translocation|nmod|END_ENTITY	Geldanamycin , a heat_shock protein 90-binding benzoquinone_ansamycin , inhibits steroid-dependent translocation of the glucocorticoid_receptor from the cytoplasm to the nucleus .
12681446	0	Geldanamycin	0,12	grp78	26,31	Geldanamycin	grp78	MESH:C001277	25617(Tax:10116)	Chemical	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	Geldanamycin induction of grp78 requires activation of reactive oxygen species via ER stress responsive elements in 9L rat brain_tumour cells .
19723345	0	Geldanamycin	0,12	heat_shock_protein_70	35,56	Geldanamycin	heat shock protein 70	MESH:C001277	266759(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|nmod|END_ENTITY	Geldanamycin induces production of heat_shock_protein_70 and partially attenuates ototoxicity caused by gentamicin in the organ of Corti explants .
10960063	0	Geldanamycin	0,12	heat_shock_protein_90	30,51	Geldanamycin	heat shock protein 90	MESH:C001277	104434(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Geldanamycin , an inhibitor of heat_shock_protein_90 -LRB- Hsp90 -RRB- mediated signal transduction has anti-inflammatory effects and interacts with glucocorticoid receptor in vivo .
14982777	0	Geldanamycin	0,12	heat_shock_protein_90	26,47	Geldanamycin	heat shock protein 90	MESH:C001277	3320	Chemical	Gene	START_ENTITY|appos|ligand ligand|nmod|END_ENTITY	Geldanamycin , a ligand of heat_shock_protein_90 , inhibits the replication of herpes_simplex_virus_type_1 in vitro .
17870069	0	Geldanamycin	0,12	vascular_endothelial_growth_factor	64,98	Geldanamycin	vascular endothelial growth factor	MESH:C001277	7422	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|compound|END_ENTITY	Geldanamycin , a HSP90 inhibitor , attenuates the hypoxia-induced vascular_endothelial_growth_factor expression in retinal pigment epithelium cells in vitro .
26254348	0	Gemcitabine	62,73	AKT	38,41	Gemcitabine	AKT	MESH:C056507	207	Chemical	Gene	Activity|compound|START_ENTITY Enhances|dobj|Activity Enhances|nsubj|Triciribine_Phosphate_Monohydrate Triciribine_Phosphate_Monohydrate|appos|Inhibitor Inhibitor|compound|END_ENTITY	Triciribine_Phosphate_Monohydrate , an AKT Inhibitor , Enhances Gemcitabine Activity in Pancreatic_Cancer Cells .
21850211	0	Gemcitabine	0,11	Akt	105,108	Gemcitabine	Akt	MESH:C056507	207	Chemical	Gene	Erlotinib|compound|START_ENTITY Resistance|nsubj|Erlotinib Resistance|nmod|Downregulation Downregulation|nmod|END_ENTITY	Gemcitabine Overcomes Erlotinib Resistance in EGFR-Overexpressing Cancer Cells through Downregulation of Akt .
24713296	0	Gemcitabine	0,11	Akt	59,62	Gemcitabine	Akt	MESH:C056507	207	Chemical	Gene	START_ENTITY|nmod|agent agent|acl:relcl|blocks blocks|dobj|cascade cascade|compound|END_ENTITY	Gemcitabine as a molecular targeting agent that blocks the Akt cascade in platinum-resistant ovarian_cancer .
26141863	0	Gemcitabine	32,43	CHK1	0,4	Gemcitabine	CHK1	MESH:C056507	1111	Chemical	Gene	Synergizes|nmod|START_ENTITY Synergizes|nsubj|Inhibition Inhibition|compound|END_ENTITY	CHK1 Inhibition Synergizes with Gemcitabine Initially by Destabilizing the DNA Replication Apparatus .
26280109	0	Gemcitabine	152,163	Deoxycytidine_Kinase	55,75	Gemcitabine	Deoxycytidine Kinase	MESH:C056507	1633	Chemical	Gene	Treatment|compound|START_ENTITY Survival|nmod|Treatment Correlates|nmod|Survival Correlates|compound|END_ENTITY	Quantitative Targeted Proteomics of Pancreatic_Cancer : Deoxycytidine_Kinase Protein Level Correlates to Progression-Free Survival of Patients Receiving Gemcitabine Treatment .
26280109	0	Gemcitabine	152,163	Deoxycytidine_Kinase	55,75	Gemcitabine	Deoxycytidine Kinase	MESH:C056507	1633	Chemical	Gene	Treatment|compound|START_ENTITY Survival|nmod|Treatment Correlates|nmod|Survival Correlates|compound|END_ENTITY	Quantitative Targeted Proteomics of Pancreatic_Cancer : Deoxycytidine_Kinase Protein Level Correlates to Progression-Free Survival of Patients Receiving Gemcitabine Treatment .
20719134	0	Gemcitabine	94,105	ERCC1	26,31	Gemcitabine	ERCC1	MESH:C056507	2067	Chemical	Gene	Chemotherapy|compound|START_ENTITY Cancer|nmod|Chemotherapy Trend|nmod|Cancer Effects|nmod|Trend Effects|nmod|RRM1 RRM1|compound|END_ENTITY	-LSB- Effects of Expression of ERCC1 , RRM1 on Survival Trend of Lung Cancer with Cisplatin Combine Gemcitabine Chemotherapy after Surgical Resection . -RSB- .
18813828	5	Gemcitabine	901,912	HCC	986,989	Gemcitabine	MEK	MESH:C056507	5609	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Gemcitabine induced differential activation of checkpoint kinases , Chk2 and Chk1 , in HCC and CCC cells , respectively and gemcitabine activated extracellular_signal-regulated_kinase _ -LRB- ERK -RRB- 1/2 in both cell types .
25275019	0	Gemcitabine	47,58	MUC4	88,92	Gemcitabine	MUC4	MESH:C056507	4585	Chemical	Gene	START_ENTITY|nmod|Expression Expression|compound|END_ENTITY	Apicidin Sensitizes Pancreatic_Cancer Cells to Gemcitabine by Epigenetically Regulating MUC4 Expression .
26709920	0	Gemcitabine	16,27	TM4SF1	0,6	Gemcitabine	TM4SF1	MESH:C056507	4071	Chemical	Gene	Resistance|compound|START_ENTITY Resistance|compound|END_ENTITY	TM4SF1 Promotes Gemcitabine Resistance of Pancreatic_Cancer In Vitro and In Vivo .
21607557	0	Gemcitabine	0,11	WT1	39,42	Gemcitabine	WT1	MESH:C056507	7490	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	Gemcitabine enhances Wilms ' _ tumor_gene WT1 expression and sensitizes human pancreatic_cancer cells with WT1-specific T-cell-mediated antitumor immune response .
16551864	0	Gemcitabine	0,11	cytidine_deaminase	30,48	Gemcitabine	cytidine deaminase	MESH:C056507	978	Chemical	Gene	pharmacogenomics|amod|START_ENTITY pharmacogenomics|dep|genomics genomics|amod|END_ENTITY	Gemcitabine pharmacogenomics : cytidine_deaminase and deoxycytidylate_deaminase gene resequencing and functional genomics .
16463058	0	Gemcitabine	0,11	deoxycytidine_kinase	30,50	Gemcitabine	deoxycytidine kinase	MESH:C056507	1633	Chemical	Gene	resistance|amod|START_ENTITY resistance|amod|due due|nmod|deficiency deficiency|amod|END_ENTITY	Gemcitabine resistance due to deoxycytidine_kinase deficiency can be reverted by fruitfly deoxynucleoside kinase , DmdNK , in human uterine_sarcoma cells .
18556440	0	Gemcitabine	0,11	deoxycytidine_kinase	30,50	Gemcitabine	deoxycytidine kinase	MESH:C056507	100348589(Tax:9986)	Chemical	Gene	pharmacogenomics|amod|START_ENTITY pharmacogenomics|dep|genomics genomics|amod|END_ENTITY	Gemcitabine pharmacogenomics : deoxycytidine_kinase and cytidylate kinase gene resequencing and functional genomics .
8494545	0	Gemcitabine	48,59	deoxycytidine_kinase	81,101	Gemcitabine	deoxycytidine kinase	MESH:C056507	1633	Chemical	Gene	difluorodeoxycytidine|appos|START_ENTITY difluorodeoxycytidine|acl|purified purified|dobj|END_ENTITY	Kinetic studies on 2 ' ,2 ' - difluorodeoxycytidine -LRB- Gemcitabine -RRB- with purified human deoxycytidine_kinase and cytidine_deaminase .
19796794	0	Gemcitabine	15,26	inducible_nitric_oxide_synthase	46,77	Gemcitabine	inducible nitric oxide synthase	MESH:C056507	4843	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of Gemcitabine and Vinorelbine on inducible_nitric_oxide_synthase -LRB- iNOS -RRB- and endothelial_nitric_oxide_synthase -LRB- eNOS -RRB- distribution of MCF-7_breast_cancer cells .
9327717	0	Gemfibrozil	0,11	insulin	93,100	Gemfibrozil	insulin	MESH:D015248	3630	Chemical	Gene	treatment|amod|START_ENTITY treatment|dep|improvement improvement|nmod|fibrinolysis fibrinolysis|nmod|change change|nmod|resistance resistance|compound|END_ENTITY	Gemfibrozil treatment of hypertriglyceridemia : improvement on fibrinolysis without change of insulin resistance .
15194707	0	Gemfibrozil	0,11	organic_anion_transporting_polypeptide_2	44,84	Gemfibrozil	organic anion transporting polypeptide 2	MESH:D015248	10599	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|END_ENTITY	Gemfibrozil and its glucuronide inhibit the organic_anion_transporting_polypeptide_2 -LRB- OATP2/OATP1B1 : SLC21A6 -RRB- - mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin : analysis of the mechanism of the clinically relevant drug-drug interaction between cerivastatin and gemfibrozil .
22685291	0	Gemfibrozil	0,11	suppressor_of_cytokine_signaling	44,76	Gemfibrozil	suppressor of cytokine signaling	MESH:D015248	12700(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Gemfibrozil , a lipid-lowering drug , induces suppressor_of_cytokine_signaling 3 in glial cells : implications for neurodegenerative_disorders .
12763281	0	Gemfibrozil	0,11	tumor_necrosis_factor-alpha	31,58	Gemfibrozil	tumor necrosis factor-alpha	MESH:D015248	7124	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|release release|nmod|END_ENTITY	Gemfibrozil reduces release of tumor_necrosis_factor-alpha in peripheral blood mononuclear cells from healthy subjects and patients with coronary_heart_disease .
26195223	0	Gemfibrozil_acyl-glucuronide	84,112	CYP2C8	147,153	Gemfibrozil acyl-glucuronide	CYP2C8	null	1558	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Underlying mechanism of drug-drug interaction between pioglitazone and gemfibrozil : Gemfibrozil_acyl-glucuronide is a mechanism-based inhibitor of CYP2C8 .
26195223	0	Gemfibrozil_acyl-glucuronide	84,112	CYP2C8	147,153	Gemfibrozil acyl-glucuronide	CYP2C8	null	1558	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Underlying mechanism of drug-drug interaction between pioglitazone and gemfibrozil : Gemfibrozil_acyl-glucuronide is a mechanism-based inhibitor of CYP2C8 .
25448307	0	Gemigliptin	0,11	dipeptidyl_peptidase-4	21,43	Gemigliptin	dipeptidyl peptidase-4	MESH:C534891	13482(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Gemigliptin , a novel dipeptidyl_peptidase-4 inhibitor , exhibits potent anti-glycation properties in vitro and in vivo .
26391252	0	Gemigliptin	0,11	dipeptidyl_peptidase-4	15,37	Gemigliptin	dipeptidyl peptidase-4	MESH:C534891	13482(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Gemigliptin , a dipeptidyl_peptidase-4 inhibitor , inhibits retinal pericyte injury in db/db mice and retinal_neovascularization in mice with ischemic_retinopathy .
24557363	0	Genipin	0,7	CCL20	31,36	Genipin	CCL20	MESH:C007834	6364	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Genipin inhibits IL-1b-induced CCL20 and IL-6 production from human periodontal ligament cells .
25457105	0	Genipin	0,7	MMP-1	17,22	Genipin	MMP-1	MESH:C007834	4312	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|amod|END_ENTITY	Genipin inhibits MMP-1 and MMP-3 release from TNF-a-stimulated human periodontal ligament cells .
26659006	0	Genipin	0,7	NLRP3	17,22	Genipin	NLRP3	MESH:C007834	216799(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|compound|END_ENTITY	Genipin inhibits NLRP3 and NLRC4 inflammasome activation via autophagy suppression .
24296130	0	Genipin	0,7	cyclooxygenase-2	16,32	Genipin	cyclooxygenase-2	MESH:C007834	19225(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Genipin induces cyclooxygenase-2 expression via NADPH oxidase , MAPKs , AP-1 , and NF-kB in RAW 264.7 cells .
26830672	0	Geniposide	0,10	AMPK	53,57	Geniposide	AMPK	MESH:C007835	5563	Chemical	Gene	Production|compound|START_ENTITY Production|nmod|END_ENTITY	Geniposide Suppresses Hepatic Glucose Production via AMPK in HepG2 Cells .
17629357	0	Geniposide	0,10	GLP-1_receptor	32,46	Geniposide	GLP-1 receptor	MESH:C007835	25051(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|nmod|END_ENTITY	Geniposide , a novel agonist for GLP-1_receptor , prevents PC12 cells from oxidative damage via MAP kinase pathway .
20686520	0	Geniposide	0,10	NF-kappaB	67,76	Geniposide	NF-kappaB	MESH:C007835	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Geniposide inhibits high glucose-induced cell adhesion through the NF-kappaB signaling pathway in human umbilical vein endothelial cells .
25445441	0	Geniposide	0,10	TLR4	72,76	Geniposide	TLR4	MESH:C007835	21898(Tax:10090)	Chemical	Gene	Inhibited|nsubj|START_ENTITY Inhibited|nmod|END_ENTITY	Geniposide Inhibited Lipopolysaccharide-induced Apoptosis by Modulating TLR4 and Apoptosis-related Factors in Mouse Mammary Glands .
21048309	0	Geniposide	0,10	heme_oxygenase-1	37,53	Geniposide	heme oxygenase-1	MESH:C007835	3162	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Geniposide induces the expression of heme_oxygenase-1 via PI3K/Nrf2-signaling to enhance the antioxidant capacity in primary hippocampal neurons .
23244428	0	Geniposide	0,10	insulin-degrading_enzyme	21,45	Geniposide	insulin-degrading enzyme	MESH:C007835	3416	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Geniposide regulates insulin-degrading_enzyme expression to inhibit the cytotoxicity of Ab in cortical neurons .
20091087	0	Geniposide	0,10	interleukin-6	20,33	Geniposide	interleukin-6	MESH:C007835	3569	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Geniposide inhibits interleukin-6 and interleukin-8 production in lipopolysaccharide-induced human umbilical vein endothelial cells by blocking p38 and ERK1/2 signaling pathways .
18598300	0	Geniposide	0,10	stem_cell_factor	37,53	Geniposide	stem cell factor	MESH:C007835	4254	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Geniposide enhances melanogenesis by stem_cell_factor / c-Kit signalling in norepinephrine-exposed normal human epidermal melanocyte .
26703673	0	Genistein	0,9	ABCC2	36,41	Genistein	ABCC2	MESH:D019833	1244	Chemical	Gene	Effects|compound|START_ENTITY Effects|nmod|END_ENTITY	Genistein and Glyceollin Effects on ABCC2 -LRB- MRP2 -RRB- and ABCG2 -LRB- BCRP -RRB- in Caco-2 Cells .
26164719	0	Genistein	110,119	Angiotensin_II	86,100	Genistein	Angiotensin II	MESH:D019833	24179(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Inhibition|dep|Role Inhibition|nmod|Induced Induced|nmod|END_ENTITY	Inhibition of TRPM7 Attenuates Rat Aortic Smooth Muscle Cell Proliferation Induced by Angiotensin_II : Role of Genistein .
12095417	0	Genistein	0,9	C/EBPbeta	56,65	Genistein	C/EBPbeta	MESH:D019833	1051	Chemical	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Genistein inhibits CCAAT/enhancer-binding _ protein_beta -LRB- C/EBPbeta -RRB- activity and 3T3-L1 adipogenesis by increasing C/EBP homologous protein expression .
15996659	0	Genistein	85,94	CFTR	63,67	Genistein	CFTR	MESH:D019833	1080	Chemical	Gene	description|dep|START_ENTITY description|nmod|activation activation|nmod|END_ENTITY	A quantitative description of the activation and inhibition of CFTR by potentiators : Genistein .
9196038	0	Genistein	0,9	CFTR	35,39	Genistein	CFTR	MESH:D019833	100135647(Tax:10141)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|current current|amod|END_ENTITY	Genistein directly induces cardiac CFTR chloride current by a tyrosine kinase-independent and protein kinase A-independent pathway in guinea_pig ventricular myocytes .
9277373	0	Genistein	0,9	CFTR	20,24	Genistein	CFTR	MESH:D019833	1080	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|Cl Cl|compound|END_ENTITY	Genistein activates CFTR Cl - channels via a tyrosine kinase - and protein phosphatase-independent mechanism .
12732287	0	Genistein	0,9	CYP24	42,47	Genistein	CYP24	MESH:D019833	1591	Chemical	Gene	inhibits|compound|START_ENTITY vitamin_D|nsubj|inhibits vitamin_D|dobj|expression expression|amod|hydroxylases hydroxylases|dep|END_ENTITY	Genistein inhibits vitamin_D hydroxylases CYP24 and CYP27B1 expression in prostate cells .
15955619	0	Genistein	0,9	CYP24	151,156	Genistein	CYP24	MESH:D019833	1591	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|effects effects|dep|role role|nmod|inhibition inhibition|nmod|activity activity|compound|END_ENTITY	Genistein potentiates the growth inhibitory effects of 1,25-dihydroxyvitamin _ D3 in DU145 human prostate_cancer cells : role of the direct inhibition of CYP24 enzyme activity .
26081033	0	Genistein	0,9	Cytochrome_P450_1B1	18,37	Genistein	Cytochrome P450 1B1	MESH:D019833	1545	Chemical	Gene	Induces|nsubj|START_ENTITY Induces|dobj|Expression Expression|compound|END_ENTITY	Genistein Induces Cytochrome_P450_1B1 Gene Expression and Cell Proliferation in Human Breast Cancer MCF-7 Cells .
25136773	0	Genistein	0,9	Glucocorticoid_Receptor	19,42	Genistein	Glucocorticoid Receptor	MESH:D019833	2908	Chemical	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	Genistein Disrupts Glucocorticoid_Receptor Signaling in Human Uterine Endometrial Ishikawa Cells .
26576346	0	Genistein	10,19	HMG-COA_Reductase	91,108	Genistein	HMG-COA Reductase	MESH:D019833	3156	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|Expression Expression|nmod|END_ENTITY	Effect of Genistein and L-Carnitine and Their Combination on Gene Expression of Hepatocyte HMG-COA_Reductase and LDL_Receptor in Experimental Nephrotic Syndrome .
22521737	0	Genistein	0,9	IL-1_beta	24,33	Genistein	IL-1 beta	MESH:D019833	3553	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Genistein regulates the IL-1_beta induced activation of MAPKs in human periodontal ligament cells through G_protein-coupled_receptor_30 .
21505982	0	Genistein	0,9	JNK	101,104	Genistein	JNK	MESH:D019833	5599	Chemical	Gene	reverses|nsubj|START_ENTITY reverses|advcl|targeting targeting|dobj|END_ENTITY	Genistein reverses free fatty_acid-induced insulin resistance in HepG2 hepatocytes through targeting JNK .
25620059	0	Genistein	0,9	NF-kB	38,43	Genistein	NF-kB	MESH:D019833	81736(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	Genistein modulates the expression of NF-kB and MAPK -LRB- p-38 and ERK1/2 -RRB- , thereby attenuating d-Galactosamine induced fulminant hepatic_failure in Wistar_rats .
16640785	0	Genistein	0,9	NF-kappaB	51,60	Genistein	NF-kappaB	MESH:D019833	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	Genistein inhibits radiation-induced activation of NF-kappaB in prostate_cancer cells promoting apoptosis and G2/M cell cycle arrest .
10693171	0	Genistein	0,9	NF-kappa_B	19,29	Genistein	NF-kappa B	MESH:D019833	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	Genistein inhibits NF-kappa_B activation in prostate_cancer cells .
12963487	0	Genistein	0,9	NF-kappa_B	18,28	Genistein	NF-kappa B	MESH:D019833	18033(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	Genistein reduces NF-kappa_B in T_lymphoma cells via a caspase-mediated cleavage of I_kappa_B_alpha .
10433940	0	Genistein	0,9	NFkappaB	46,54	Genistein	NFkappaB	MESH:D019833	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|compound|END_ENTITY	Genistein inhibits constitutive and inducible NFkappaB activation and decreases IL-8 production by human cystic_fibrosis bronchial gland cells .
22272764	8	Genistein	1161,1170	Nrf2	1269,1273	Genistein	PI3K	MESH:D019833	18708(Tax:10090)	Chemical	Gene	reverse|nsubj|START_ENTITY reverse|dobj|down-regulation down-regulation|nmod|protein protein|nmod|NF-E2-related_factor_2 NF-E2-related_factor_2|appos|END_ENTITY	Genistein could reverse the down-regulation of total protein and mRNA expression of NF-E2-related_factor_2 -LRB- Nrf2 -RRB- , nuclear Nrf2 , y-glutamylcysteine synthetase -LRB- y-GCS -RRB- , phosphatidylinositol_3-kinase -LRB- PI3K -RRB- induced by Ab25-35 ; while PI3K inhibitor LY294002 could attenuate the activation effects of genistein on Nrf2 , especially for the promotion of nuclear translocation .
17449569	0	Genistein	0,9	SREBP-1	24,31	Genistein	SREBP-1	MESH:D019833	6720	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	Genistein downregulates SREBP-1 regulated gene expression by inhibiting site-1_protease expression in HepG2 cells .
23291378	0	Genistein	0,9	VCAM-1	34,40	Genistein	VCAM-1	MESH:D019833	7412	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Genistein inhibits ox-LDL-induced VCAM-1 , ICAM-1 and MCP-1 expression of HUVECs through heme_oxygenase-1 .
18852123	0	Genistein	0,9	androgen_receptor	25,42	Genistein	androgen receptor	MESH:D019833	367	Chemical	Gene	down-regulates|compound|START_ENTITY END_ENTITY|nsubj|down-regulates	Genistein down-regulates androgen_receptor by modulating HDAC6-Hsp90 chaperone function .
10406836	0	Genistein	0,9	c-fos	50,55	Genistein	c-fos	MESH:D019833	314322(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Genistein inhibits pressure-induced expression of c-fos in isolated mesenteric arteries .
19840237	0	Genistein	0,9	cAMP_response_element-binding_protein	37,74	Genistein	cAMP response element-binding protein	MESH:D019833	81646(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Genistein induces phosphorylation of cAMP_response_element-binding_protein in neonatal hypothalamus in vivo .
21816468	0	Genistein	0,9	corticotropin-releasing_hormone	32,63	Genistein	corticotropin-releasing hormone	MESH:D019833	12918(Tax:10090)	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Genistein upregulates placental corticotropin-releasing_hormone expression in lipopolysaccharide-sensitized mice .
21205922	0	Genistein	0,9	cytochrome_P450_4F2	87,106	Genistein	cytochrome P450 4F2	MESH:D019833	8529	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|amod|END_ENTITY	Genistein , resveratrol , and 5-aminoimidazole-4-carboxamide-1-b-D-ribofuranoside induce cytochrome_P450_4F2 expression through an AMP-activated_protein_kinase-dependent pathway .
19288574	0	Genistein	0,9	epidermal_growth_factor_receptor	33,65	Genistein	epidermal growth factor receptor	MESH:D019833	1956	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|effect effect|nmod|inhibitors inhibitors|compound|END_ENTITY	Genistein enhances the effect of epidermal_growth_factor_receptor tyrosine kinase inhibitors and inhibits nuclear_factor_kappa_B in nonsmall_cell_lung_cancer cell lines .
21111822	0	Genistein	0,9	epidermal_growth_factor_receptor	96,128	Genistein	epidermal growth factor receptor	MESH:D019833	24329(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|transactivation transactivation|nmod|END_ENTITY	Genistein enhances relaxation of the spontaneously hypertensive rat aorta by transactivation of epidermal_growth_factor_receptor following binding to membrane estrogen receptors-a and activation of a G protein-coupled , endothelial nitric_oxide synthase-dependent pathway .
21603581	0	Genistein	0,9	epidermal_growth_factor_receptor	20,52	Genistein	epidermal growth factor receptor	MESH:D019833	1956	Chemical	Gene	increases|compound|START_ENTITY END_ENTITY|nsubj|increases	Genistein increases epidermal_growth_factor_receptor signaling and promotes tumor progression in advanced human prostate_cancer .
9309250	0	Genistein	0,9	epidermal_growth_factor_receptor	32,64	Genistein	epidermal growth factor receptor	MESH:D019833	1956	Chemical	Gene	analogues|compound|START_ENTITY analogues|dep|effects effects|nmod|kinase kinase|compound|END_ENTITY	Genistein analogues : effects on epidermal_growth_factor_receptor tyrosine kinase and on stress-activated pathways .
25931004	0	Genistein	0,9	estrogen_receptor	20,37	Genistein	estrogen receptor	MESH:D019833	2099	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Genistein increases estrogen_receptor beta expression in prostate_cancer via reducing its promoter methylation .
16579725	0	Genistein	0,9	glucose-regulated_protein_78	18,46	Genistein	glucose-regulated protein 78	MESH:D019833	3309	Chemical	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Genistein induces glucose-regulated_protein_78 in mammary_tumor cells .
15834450	0	Genistein	0,9	hypoxia-inducible_factor-1alpha	20,51	Genistein	hypoxia-inducible factor-1alpha	MESH:D019833	3091	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|dobj|expression expression|amod|END_ENTITY	Genistein inhibited hypoxia-inducible_factor-1alpha expression induced by hypoxia and cobalt_chloride in human retinal pigment epithelium cells .
1310987	0	Genistein	0,9	insulin	107,114	Genistein	insulin	MESH:D019833	3630	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|inhibiting inhibiting|dobj|kinase kinase|compound|END_ENTITY	Genistein differentially inhibits postreceptor effects of insulin in rat adipocytes without inhibiting the insulin receptor kinase .
1310987	0	Genistein	0,9	insulin	58,65	Genistein	insulin	MESH:D019833	3630	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|effects effects|nmod|END_ENTITY	Genistein differentially inhibits postreceptor effects of insulin in rat adipocytes without inhibiting the insulin receptor kinase .
1851473	0	Genistein	0,9	interleukin-2	67,80	Genistein	interleukin-2	MESH:D019833	3558	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	Genistein , a selective protein_tyrosine_kinase inhibitor , inhibits interleukin-2 and leukotriene B4 production from human mononuclear cells .
17658479	0	Genistein	0,9	kangai-1	44,52	Genistein	kangai-1	MESH:D019833	3732	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Genistein induces the metastasis suppressor kangai-1 which mediates its anti-invasive effects in TRAMP cancer cells .
16772519	0	Genistein	0,9	matrix_metalloproteinase_type_2	19,50	Genistein	matrix metalloproteinase type 2	MESH:D019833	4313	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	Genistein inhibits matrix_metalloproteinase_type_2 activation and prostate_cancer cell invasion by blocking the transforming_growth_factor_beta-mediated activation of mitogen-activated protein kinase-activated protein kinase 2-27-kDa heat_shock protein pathway .
25871428	0	Genistein	0,9	miR-95	65,71	Genistein	miR-95	MESH:D019833	407052	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Genistein inhibits human colorectal_cancer growth and suppresses miR-95 , Akt and SGK1 .
21843532	0	Genistein	0,9	p21	105,108	Genistein	p21	MESH:D019833	1026	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|dobj|formation formation|nmod|centrosomes centrosomes|nmod|up-regulation up-regulation|amod|END_ENTITY	Genistein , isoflavonoids in soybeans , prevents the formation of excess radiation-induced centrosomes via p21 up-regulation .
9790949	0	Genistein	0,9	p21	18,21	Genistein	p21	MESH:D019833	12575(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Genistein induces p21 -LRB- Cip1/WAF1 -RRB- expression and blocks the G1 to S phase transition in mouse fibroblast and melanoma cells .
12514295	0	Genistein	0,9	p38	20,23	Genistein	p38	MESH:D019833	5594	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|kinase kinase|nummod|END_ENTITY	Genistein activates p38 mitogen-activated protein kinase , inactivates ERK1/ERK2 and decreases Cdc25C expression in immortalized human mammary epithelial cells .
15833883	0	Genistein	0,9	p38	19,22	Genistein	p38	MESH:D019833	1432	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	Genistein inhibits p38 map kinase activation , matrix_metalloproteinase_type_2 , and cell invasion in human prostate epithelial cells .
24290959	0	Genistein	0,9	p38	75,78	Genistein	p38	MESH:D019833	26416(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|inducing inducing|dobj|activation activation|amod|END_ENTITY	Genistein induces morphology change and G2/M cell cycle arrest by inducing p38 MAPK activation in macrophages .
22304296	0	Genistein	0,9	paraoxonase-1	64,77	Genistein	paraoxonase-1	MESH:D019833	84024(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inducer inducer|nmod|END_ENTITY	Genistein as a potential inducer of the anti-atherogenic enzyme paraoxonase-1 : studies in cultured hepatocytes in vitro and in rat liver in vivo .
22304296	0	Genistein	0,9	paraoxonase-1	64,77	Genistein	paraoxonase-1	MESH:D019833	84024(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inducer inducer|nmod|END_ENTITY	Genistein as a potential inducer of the anti-atherogenic enzyme paraoxonase-1 : studies in cultured hepatocytes in vitro and in rat liver in vivo .
16768824	0	Genistein	0,9	parathyroid_hormone	35,54	Genistein	parathyroid hormone	MESH:D019833	5741	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|effects effects|nmod|END_ENTITY	Genistein modulates the effects of parathyroid_hormone in human osteoblastic SaOS-2 cells .
22038372	0	Genistein	0,9	presenilin_1	24,36	Genistein	presenilin 1	MESH:D019833	5663	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	Genistein downregulates presenilin_1 and ubiquilin_1 expression .
1851473	0	Genistein	0,9	protein_tyrosine_kinase	23,46	Genistein	protein tyrosine kinase	MESH:D019833	2264	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Genistein , a selective protein_tyrosine_kinase inhibitor , inhibits interleukin-2 and leukotriene B4 production from human mononuclear cells .
21570948	0	Genistein	0,9	protein_tyrosine_kinase	106,129	Genistein	protein tyrosine kinase	MESH:D019833	2264	Chemical	Gene	inhibit|dep|START_ENTITY inhibit|nsubj|channels channels|acl|expressed expressed|nmod|cells cells|nmod|inhibition inhibition|amod|END_ENTITY	Genistein and tyrphostin_AG556 inhibit inwardly-rectifying Kir2 .1 channels expressed in HEK 293 cells via protein_tyrosine_kinase inhibition .
24504368	0	Genistein	0,9	sFRP1	55,60	Genistein	sFRP1	MESH:D019833	6422	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	Genistein downregulates onco-miR-1260b and upregulates sFRP1 and Smad4 via demethylation and histone modification in prostate_cancer cells .
10845426	0	Genistein	0,9	transforming_growth_factor-alpha	24,56	Genistein	transforming growth factor-alpha	MESH:D019833	24827(Tax:10116)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Genistein regulation of transforming_growth_factor-alpha , epidermal_growth_factor -LRB- EGF -RRB- , and EGF receptor expression in the rat uterus and vagina .
21220916	0	Gensenoside_Rg3	0,15	VEGF	41,45	Gensenoside Rg3	VEGF	null	7422	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Gensenoside_Rg3 inhibits hypoxia-induced VEGF expression in human cancer cells .
17699551	0	Gentamicin	0,10	TNF-alpha	39,48	Gentamicin	TNF-alpha	MESH:D005839	7124	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|production production|amod|END_ENTITY	Gentamicin suppresses endotoxin-driven TNF-alpha production in human and mouse proximal tubule cells .
22896926	0	Gentamicin	0,10	connexin_26	19,30	Gentamicin	connexin 26	MESH:D005839	394266(Tax:10116)	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|expression expression|amod|END_ENTITY	Gentamicin affects connexin_26 expression in the cochlear lateral wall .
25423092	0	Gentiolactone	0,13	TNF-a	72,77	Gentiolactone	TNF-a	null	21926(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Gentiolactone , a secoiridoid_dilactone from Gentiana triflora , inhibits TNF-a , iNOS and Cox-2 mRNA expression and blocks NF-kB promoter activity in murine macrophages .
25423092	0	Gentiolactone	0,13	iNOS	79,83	Gentiolactone	iNOS	null	18126(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Gentiolactone , a secoiridoid_dilactone from Gentiana triflora , inhibits TNF-a , iNOS and Cox-2 mRNA expression and blocks NF-kB promoter activity in murine macrophages .
21415217	0	Genz-644282	0,11	topoisomerase_I	38,53	Genz-644282	topoisomerase I	MESH:C560916	7150	Chemical	Gene	inhibitor|advmod|START_ENTITY inhibitor|nsubj|END_ENTITY	Genz-644282 , a novel non-camptothecin topoisomerase_I inhibitor for cancer treatment .
21636699	0	Genz-644282	91,102	topoisomerase_I	65,80	Genz-644282	topoisomerase I	MESH:C560916	7150	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|pharmacology pharmacology|nmod|END_ENTITY	Molecular and cellular pharmacology of the novel noncamptothecin topoisomerase_I inhibitor Genz-644282 .
1978370	0	Gepirone	0,8	5-HT1A	14,20	Gepirone	5-HT1A	MESH:C039979	3350	Chemical	Gene	START_ENTITY|nmod|agonist agonist|amod|END_ENTITY	Gepirone as a 5-HT1A agonist in the treatment of major_depression .
25682949	0	Geranyl_Dihydrochalcone	52,75	STAT3	84,89	Geranyl Dihydrochalcone	STAT3	null	6774	Chemical	Gene	Activity|compound|START_ENTITY Activity|compound|END_ENTITY	Artocarpus altilis -LRB- Parkinson -RRB- Fosberg Extracts and Geranyl_Dihydrochalcone Inhibit STAT3 Activity in Prostate_Cancer DU145 Cells .
22019459	0	Geranylgeranyl_pyrophosphate	0,28	PPARy	40,45	Geranylgeranyl pyrophosphate	PPARy	MESH:C002963	5468	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	Geranylgeranyl_pyrophosphate stimulates PPARy expression and adipogenesis through the inhibition of osteoblast differentiation .
26345206	0	Geranylgeranylacetone	0,21	HSP70	47,52	Geranylgeranylacetone	HSP70	MESH:C031049	3308	Chemical	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Geranylgeranylacetone selectively binds to the HSP70 of Helicobacter_pylori and alters its coccoid morphology .
26345206	0	Geranylgeranylacetone	0,21	HSP70	47,52	Geranylgeranylacetone	HSP70	MESH:C031049	3308	Chemical	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Geranylgeranylacetone selectively binds to the HSP70 of Helicobacter_pylori and alters its coccoid morphology .
17404846	0	Geranylgeranylacetone	0,21	cyclooxygenase-2	30,46	Geranylgeranylacetone	cyclooxygenase-2	MESH:C031049	29527(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Geranylgeranylacetone induces cyclooxygenase-2 expression in cultured rat gastric epithelial cells through NF-kappaB .
16406313	0	Geranylgeranylacetone	0,21	heat_shock_protein	37,55	Geranylgeranylacetone	heat shock protein	MESH:C031049	290549(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inducer inducer|compound|END_ENTITY	Geranylgeranylacetone , a noninvasive heat_shock_protein inducer , induces protein kinase C and leads to neuroprotection against cerebral_infarction in rats .
18703712	0	Germline	0,8	TGFBR1	39,45	Germline	TGFBR1	null	7046	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Germline allele-specific expression of TGFBR1 confers an increased risk of colorectal_cancer .
9869411	0	Gibberellin	0,11	GAST1	39,44	Gibberellin	GAST1	CHEBI:28833	101248254	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|compound|END_ENTITY	Gibberellin and abscisic_acid regulate GAST1 expression at the level of transcription .
25738547	0	Gibberellin	0,11	PIF4	51,55	Gibberellin	PIF4	CHEBI:28833	818903(Tax:3702)	Chemical	Gene	requires|nsubj|START_ENTITY requires|dobj|END_ENTITY	Gibberellin driven growth in elf3 mutants requires PIF4 and PIF5 .
21668582	0	Gimeracil	0,9	dihydropyrimidine_dehydrogenase	27,58	Gimeracil	dihydropyrimidine dehydrogenase	MESH:C104201	1806	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Gimeracil , an inhibitor of dihydropyrimidine_dehydrogenase , inhibits the early step in homologous recombination .
24069345	0	Ginkgolide_B	0,12	LOX-1	21,26	Ginkgolide B	LOX-1	MESH:C045856	4973	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|compound|END_ENTITY	Ginkgolide_B reduces LOX-1 expression by inhibiting Akt phosphorylation and increasing Sirt1 expression in oxidized LDL-stimulated human umbilical vein endothelial cells .
19609067	0	Ginkgolide_B	0,12	intercellular_adhesion_molecule-1	24,57	Ginkgolide B	intercellular adhesion molecule-1	MESH:C045856	3383	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Ginkgolide_B suppresses intercellular_adhesion_molecule-1 expression via blocking nuclear_factor-kappaB activation in human vascular endothelial cells stimulated by oxidized low-density lipoprotein .
21122802	0	Ginsenoside-Rd	0,14	apoE	98,102	Ginsenoside-Rd	apoE	MESH:C049863	11816(Tax:10090)	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|dobj|atherosclerosis atherosclerosis|nmod|mice mice|amod|END_ENTITY	Ginsenoside-Rd , a purified component from panax notoginseng saponins , prevents atherosclerosis in apoE knockout mice .
17008323	0	Ginsenoside-Rg1	0,15	Akt	144,147	Ginsenoside-Rg1	Akt	MESH:C035054	207	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Ginsenoside-Rg1 induces vascular_endothelial_growth_factor expression through the glucocorticoid_receptor-related phosphatidylinositol_3-kinase / Akt and beta-catenin/T-cell factor-dependent pathway in human endothelial cells .
17008323	0	Ginsenoside-Rg1	0,15	vascular_endothelial_growth_factor	24,58	Ginsenoside-Rg1	vascular endothelial growth factor	MESH:C035054	7422	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Ginsenoside-Rg1 induces vascular_endothelial_growth_factor expression through the glucocorticoid_receptor-related phosphatidylinositol_3-kinase / Akt and beta-catenin/T-cell factor-dependent pathway in human endothelial cells .
22692056	0	Ginsenoside_Rb	0,14	peroxisome_proliferator-activated_receptor-delta	61,109	Ginsenoside Rb	peroxisome proliferator-activated receptor-delta	null	5467	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Ginsenoside_Rb induces type I collagen expression through peroxisome_proliferator-activated_receptor-delta .
26645822	0	Ginsenoside_Rb1	55,70	Connexin40	15,25	Ginsenoside Rb1	Connexin40	MESH:C442759	14613(Tax:10090)	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of Connexin40 in the Protective Effects of Ginsenoside_Rb1 Against Traumatic_Brain_Injury .
20678598	0	Ginsenoside_Rb1	0,15	IL-8	92,96	Ginsenoside Rb1	IL-8	MESH:C442759	3576	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|END_ENTITY	Ginsenoside_Rb1 and paeoniflorin inhibit transient_receptor_potential_vanilloid-1-activated IL-8 and PGE production in a human keratinocyte cell line HaCaT .
26062798	0	Ginsenoside_Rb1	0,15	matrix_metalloproteinase_13	25,52	Ginsenoside Rb1	matrix metalloproteinase 13	MESH:C442759	171052(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Ginsenoside_Rb1 inhibits matrix_metalloproteinase_13 through down-regulating Notch signaling pathway in osteoarthritis .
20934608	0	Ginsenoside_Rb1	0,15	protein_kinase_A	89,105	Ginsenoside Rb1	protein kinase A	MESH:C442759	25636(Tax:10116)	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|pathway pathway|compound|END_ENTITY	Ginsenoside_Rb1 promotes PC12 cell cycle kinetics through an adenylate cyclase-dependent protein_kinase_A pathway .
18981572	0	Ginsenoside_Rb1	0,15	vascular_cell_adhesion_molecule-1	61,94	Ginsenoside Rb1	vascular cell adhesion molecule-1	MESH:C442759	7412	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Ginsenoside_Rb1 inhibits tumor_necrosis_factor-alpha-induced vascular_cell_adhesion_molecule-1 expression in human endothelial cells .
24376419	0	Ginsenoside_Rd	0,14	GLT-1	89,94	Ginsenoside Rd	GLT-1	MESH:C049863	29482(Tax:10116)	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Ginsenoside_Rd promotes glutamate clearance by up-regulating glial glutamate transporter GLT-1 via PI3K/AKT and ERK1/2 pathways .
18819875	0	Ginsenoside_Rg1	1,16	COX-2	27,32	Ginsenoside Rg1	COX-2	MESH:C035054	19225(Tax:10090)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|compound|END_ENTITY	-LSB- Ginsenoside_Rg1 modulates COX-2 expression in the substantia nigra of mice with MPTP-induced Parkinson_disease through the P38 signaling pathway -RSB- .
25716562	0	Ginsenoside_Rg1	0,15	Caspase-3	46,55	Ginsenoside Rg1	Caspase-3	MESH:C035054	25402(Tax:10116)	Chemical	Gene	Activation|compound|START_ENTITY Activation|compound|END_ENTITY	Ginsenoside_Rg1 Attenuates Isoflurane-induced Caspase-3 Activation via Inhibiting Mitochondrial Dysfunction .
24053327	0	Ginsenoside_Rg1	0,15	TSLP	29,33	Ginsenoside Rg1	TSLP	MESH:C035054	53603(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	Ginsenoside_Rg1 inhibits the TSLP production in allergic_rhinitis mice .
24287922	0	Ginsenoside_Rg1	0,15	neprilysin	101,111	Ginsenoside Rg1	neprilysin	MESH:C035054	17380(Tax:10090)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|neurofibrillary_tangles_accumulation neurofibrillary_tangles_accumulation|nmod|model model|amod|retina retina|advcl|regulating regulating|dobj|activities activities|nmod|END_ENTITY	Ginsenoside_Rg1 decreases neurofibrillary_tangles_accumulation in retina by regulating activities of neprilysin and PKA in retinal cells of AD mice model .
22062806	0	Ginsenoside_Rg2	0,15	SHP	48,51	Ginsenoside Rg2	SHP	MESH:C026474	8431	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Ginsenoside_Rg2 induces orphan nuclear receptor SHP gene expression and inactivates GSK3b via AMP-activated protein kinase to inhibit hepatic_glucose_production in HepG2 cells .
26636541	0	Ginsenoside_Rg3	0,15	FUT4	112,116	Ginsenoside Rg3	FUT4	MESH:C097367	14345(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Ginsenoside_Rg3 inhibits epithelial-mesenchymal transition -LRB- EMT -RRB- and invasion of lung_cancer by down-regulating FUT4 .
24966925	0	Ginsenoside_Rg3	0,15	HIF-1a	25,31	Ginsenoside Rg3	HIF-1a	MESH:C097367	3091	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Ginsenoside_Rg3 inhibits HIF-1a and VEGF expression in patient with acute_leukemia via inhibiting the activation of PI3K/Akt and ERK1/2 pathways .
22314224	0	Ginsenoside_Rh1	0,15	matrix_metalloproteinase-1	27,53	Ginsenoside Rh1	matrix metalloproteinase-1	MESH:C425564	4312	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Ginsenoside_Rh1 suppresses matrix_metalloproteinase-1 expression through inhibition of activator_protein-1 and mitogen-activated protein kinase signaling pathway in human hepatocellular_carcinoma cells .
25835975	0	Ginsenoside_Rh2	0,15	MMP13	85,90	Ginsenoside Rh2	MMP13	MESH:C055305	4322	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Ginsenoside_Rh2 inhibits metastasis of glioblastoma multiforme through Akt-regulated MMP13 .
22026999	0	Ginsenoside_Rh2	0,15	PKD	119,122	Ginsenoside Rh2	PKD	MESH:C055305	18760(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Ginsenoside_Rh2 -LRB- S -RRB- induces the differentiation and mineralization of osteoblastic MC3T3-E1 cells through activation of PKD and p38_MAPK pathways .
26783250	0	Ginsenoside_Rh2	0,15	b-catenin	58,67	Ginsenoside Rh2	b-catenin	MESH:C055305	1499	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Ginsenoside_Rh2 inhibits hepatocellular_carcinoma through b-catenin and autophagy .
25431263	0	Ginsenoside_Rh2	0,15	mTor	67,71	Ginsenoside Rh2	mTor	MESH:C055305	21977(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Ginsenoside_Rh2 inhibits growth of glioblastoma multiforme through mTor .
21194832	0	Ginsenoside_Rh2	0,15	p53	114,117	Ginsenoside Rh2	p53	MESH:C055305	7157	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Ginsenoside_Rh2 induces apoptosis and paraptosis-like cell death in colorectal_cancer cells through activation of p53 .
25908625	0	Ginsenoside_Ro	0,14	NF-kB	110,115	Ginsenoside Ro	NF-kB	MESH:C064378	309165(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	Ginsenoside_Ro suppresses interleukin-1b-induced apoptosis and inflammation in rat chondrocytes by inhibiting NF-kB .
26923348	0	Ginsenosides	39,51	Cyp1a2	23,29	Ginsenosides	Cyp1a2	MESH:D036145	13077(Tax:10090)	Chemical	Gene	Suppression|nmod|START_ENTITY Suppression|nmod|END_ENTITY	Suppression of Hepatic Cyp1a2 by Total Ginsenosides in Lipopolysaccharide-Treated Mice and Primary Mouse Hepatocytes .
23486342	0	Givinostat	33,43	IL-1b	60,65	Givinostat	IL-1b	MESH:C575255	24494(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	The lysine deacetylase inhibitor Givinostat inhibits b-cell IL-1b induced IL-1b transcription and processing .
23486342	0	Givinostat	33,43	IL-1b	74,79	Givinostat	IL-1b	MESH:C575255	24494(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|IL-1b IL-1b|acl|induced induced|dobj|transcription transcription|amod|END_ENTITY	The lysine deacetylase inhibitor Givinostat inhibits b-cell IL-1b induced IL-1b transcription and processing .
22579713	0	Givinostat	19,29	NFE2	80,84	Givinostat	NFE2	MESH:C575255	4778	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	The HDAC inhibitor Givinostat modulates the hematopoietic transcription factors NFE2 and C-MYB in JAK2 -LRB- V617F -RRB- myeloproliferative_neoplasm cells .
19295535	0	Gl181771X	48,57	cholecystokinin-A	15,32	Gl181771X	cholecystokinin-A	null	886	Chemical	Gene	receptors|nmod|START_ENTITY receptors|amod|END_ENTITY	Stimulation of cholecystokinin-A receptors with Gl181771X : a failed clinical trial that did not test the pharmacogenetic hypothesis for reduction_of_food_intake .
8794734	0	Gla	28,31	coagulation_factor_X	51,71	Gla	coagulation factor X	CHEBI:28661	2159	Chemical	Gene	domains|compound|START_ENTITY domains|nmod|END_ENTITY	The relative orientation of Gla and EGF domains in coagulation_factor_X is altered by Ca2 + binding to the first EGF domain .
12590456	0	Glabrene	0,8	tyrosinase	34,44	Glabrene	tyrosinase	MESH:C439678	7299	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Glabrene and isoliquiritigenin as tyrosinase inhibitors from licorice roots .
25737160	0	Glabridin	0,9	iNOS	58,62	Glabridin	iNOS	MESH:C107601	18126(Tax:10090)	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	Glabridin , an isoflavan from licorice root , downregulates iNOS expression and activity under high-glucose stress and inflammation .
16354764	0	Glabridin	0,9	intercellular_adhesion_molecule-1	21,54	Glabridin	intercellular adhesion molecule-1	MESH:C107601	3383	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Glabridin suppresses intercellular_adhesion_molecule-1 expression in tumor_necrosis_factor-alpha-stimulated human umbilical vein endothelial cells by blocking sphingosine kinase pathway : implications of Akt , extracellular_signal-regulated_kinase , and nuclear factor-kappaB/Rel signaling pathways .
26455358	0	Glabridin	0,9	paraoxonase_2	56,69	Glabridin	paraoxonase 2	MESH:C107601	330260(Tax:10090)	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Glabridin , an isoflavan from licorice root , upregulates paraoxonase_2 expression under hyperglycemia and protects it from oxidation .
26641551	0	Glafenine	33,42	SLC4A11	121,128	Glafenine	SLC4A11	MESH:D005897	83959	Chemical	Gene	START_ENTITY|nmod|Mutants Mutants|nmod|END_ENTITY	High Throughput Assay Identifies Glafenine as a Corrector for the Folding Defect in Corneal_Dystrophy-Causing Mutants of SLC4A11 .
11389171	0	Glatiramer_acetate	0,18	RANTES	69,75	Glatiramer acetate	RANTES	MESH:C089995	6352	Chemical	Gene	inhibition|amod|START_ENTITY END_ENTITY|nsubj|inhibition	Glatiramer_acetate inhibition of tumor_necrosis_factor-alpha-induced RANTES expression and release from U-251_MG human astrocytic cells .
21046275	0	Glatiramer_acetate	0,18	TNF-a	29,34	Glatiramer acetate	TNF-a	MESH:C089995	24835(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|secretion secretion|amod|END_ENTITY	Glatiramer_acetate modulates TNF-a and IL-10 secretion in microglia and promotes their phagocytic activity .
9548401	0	Glatiramer_acetate	0,18	interferon-gamma	59,75	Glatiramer acetate	interferon-gamma	MESH:C089995	3458	Chemical	Gene	blocks|nsubj|START_ENTITY blocks|nmod|END_ENTITY	Glatiramer_acetate blocks the activation of THP-1 cells by interferon-gamma .
11548979	0	Glatiromer_acetate	116,134	myelin_basic_protein	74,94	Glatiromer acetate	myelin basic protein	null	4155	Chemical	Gene	patients|nmod|START_ENTITY END_ENTITY|nmod|patients	Glatiramer_acetate induces a Th2-biased response and crossreactivity with myelin_basic_protein in patients with MS. Glatiromer_acetate -LRB- GA -RRB- is an approved treatment for multiple_sclerosis -LRB- MS -RRB- .
24289581	0	Glaucocalyxin_A	0,15	FasL	26,30	Glaucocalyxin A	FasL	MESH:C055124	356	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Glaucocalyxin_A activates FasL and induces apoptosis through activation of the JNK pathway in human breast_cancer cells .
12107080	0	GlcNAc	24,30	GlcNAc6ST-2	53,64	GlcNAc	GlcNAc6ST-2	CHEBI:506227	10164	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Ectopic expression of a GlcNAc 6-O-sulfotransferase , GlcNAc6ST-2 , in colonic mucinous_adenocarcinoma .
12626393	0	GlcNAc	79,85	beta1,6N-acetylglucosaminyltransferase	93,131	GlcNAc	beta1,6N-acetylglucosaminyltransferase	CHEBI:506227	64043(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|-RSB- -RSB-|amod|END_ENTITY	Purification and cDNA cloning of UDP-GlcNAc : GlcNAcbeta1-3Galbeta1-4Glc -LRB- NAc -RRB- - R -LSB- GlcNAc to Gal -RSB- beta1,6N-acetylglucosaminyltransferase from rat small intestine : a major carrier of dIGnT activity in rat small intestine .
20822912	0	GlcNAc-selenazoline	18,37	OGA	0,3	GlcNAc-selenazoline	OGA	null	10724	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|END_ENTITY	OGA inhibition by GlcNAc-selenazoline .
17177381	0	GlcNAcstatin	0,12	O-GlcNAcase	37,48	GlcNAcstatin	O-GlcNAcase	null	10724	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	GlcNAcstatin : a picomolar , selective O-GlcNAcase inhibitor that modulates intracellular O-glcNAcylation levels .
10441486	0	Glibenclamide	0,13	CFTR	107,111	Glibenclamide	CFTR	MESH:D005905	1080	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|inhibition inhibition|nmod|channels channels|appos|END_ENTITY	Glibenclamide induces apoptosis through inhibition of cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- Cl -LRB- - -RRB- channels and intracellular Ca -LRB- 2 + -RRB- release in HepG2 human hepatoblastoma cells .
8770056	0	Glibenclamide	0,13	CFTR	26,30	Glibenclamide	CFTR	MESH:D005905	1080	Chemical	Gene	START_ENTITY|dobj|blockade blockade|nmod|channels channels|amod|END_ENTITY	Glibenclamide blockade of CFTR chloride channels .
8254041	5	Glibenclamide	1078,1091	bradykinin	1138,1148	Glibenclamide	bradykinin	MESH:D005905	3827	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|nmod|END_ENTITY	Glibenclamide did not inhibit membrane hyperpolarization to bradykinin .
9283792	0	Glibenclamide	0,13	insulin	88,95	Glibenclamide	insulin	MESH:D005905	3630	Chemical	Gene	increases|nsubj|START_ENTITY increases|ccomp|parallel parallel|nmod|changes changes|nmod|END_ENTITY	Glibenclamide , but not acarbose , increases leptin concentrations parallel to changes in insulin in subjects with NIDDM .
2143093	0	Glibenclamide	0,13	thromboxane_A2_receptor	49,72	Glibenclamide	thromboxane A2 receptor	MESH:D005905	485056(Tax:9615)	Chemical	Gene	antagonist|nsubj|START_ENTITY antagonist|nmod|END_ENTITY	Glibenclamide is a competitive antagonist of the thromboxane_A2_receptor in dog coronary artery in vitro .
26534614	0	Glibenclamide_And_Gliclazide	135,163	Insulin	115,122	Glibenclamide And Gliclazide	Insulin	null	3630	Chemical	Gene	Insulin|appos|START_ENTITY Insulin|appos|END_ENTITY	Efficacy And Safety of Antidiabetic Drugs Available on Brazilian Public Health System -LRB- Sus -RRB- - Regular Insulin , Nph Insulin , Metformin , Glibenclamide_And_Gliclazide - In Treatment of Type 2 Diabetes -LRB- T2dm -RRB- - Systematic Review And Meta-Analysis .
10407367	0	Glibornuride	14,26	Atrial_Natriuretic_Factor	37,62	Glibornuride	Atrial Natriuretic Factor	MESH:C073323	4878	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|Levels Levels|compound|END_ENTITY	The Effect of Glibornuride on Plasma Atrial_Natriuretic_Factor Levels in Patients with Newly Diagnosed NIDDM .
11151028	0	Gliclazide	0,10	insulin	55,62	Gliclazide	insulin	MESH:D005907	3630	Chemical	Gene	insulin|amod|START_ENTITY efficient|nsubj|insulin efficient|nmod|END_ENTITY	Gliclazide and bedtime insulin are more efficient than insulin alone for type 2 diabetic patients with sulfonylurea secondary failure .
11456286	0	Gliclazide	0,10	insulin	26,33	Gliclazide	insulin	MESH:D005907	3630	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|secretion secretion|compound|END_ENTITY	Gliclazide mainly affects insulin secretion in second phase of type_2_diabetes_mellitus .
3882491	0	Gliclazide	0,10	insulin	66,73	Gliclazide	insulin	MESH:D005907	3630	Chemical	Gene	therapy|amod|START_ENTITY associated|nsubjpass|therapy associated|nmod|potentiation potentiation|acl|postbinding postbinding|dobj|action action|compound|END_ENTITY	Gliclazide therapy is associated with potentiation of postbinding insulin action in obese , non-insulin-dependent diabetic subjects .
3915271	0	Gliclazide	0,10	insulin	42,49	Gliclazide	insulin	MESH:D005907	3630	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|response response|compound|END_ENTITY	Gliclazide on long-term therapy increases insulin response to glucose of type_II_diabetics .
24952384	0	Glimepiride	0,11	CD14	20,24	Glimepiride	CD14	MESH:C057619	12475(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|compound|END_ENTITY	Glimepiride reduces CD14 expression and cytokine secretion from macrophages .
20011040	0	Glimepiride	0,11	PrPc	38,42	Glimepiride	PrPc	MESH:C057619	5621	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|nmod|END_ENTITY	Glimepiride reduces the expression of PrPc , prevents PrPSc formation and protects against prion mediated neurotoxicity in cell lines .
14633838	0	Glimepiride	0,11	adiponectin	22,33	Glimepiride	adiponectin	MESH:C057619	9370	Chemical	Gene	level|compound|START_ENTITY level|compound|END_ENTITY	Glimepiride and serum adiponectin level in type 2 diabetic subjects : response to Nagasaka et al. .
18564176	0	Glimepiride	0,11	eNOS	24,28	Glimepiride	eNOS	MESH:C057619	4846	Chemical	Gene	upregulates|amod|START_ENTITY END_ENTITY|nsubj|upregulates	Glimepiride upregulates eNOS activity and inhibits cytokine-induced NF-kappaB activation through a phosphoinoside 3-kinase-Akt-dependent pathway .
12196435	0	Glimepiride	0,11	insulin	53,60	Glimepiride	insulin	MESH:C057619	3630	Chemical	Gene	improves|nsubj|START_ENTITY improves|dobj|phases phases|nmod|secretion secretion|compound|END_ENTITY	Glimepiride improves both first and second phases of insulin secretion in type 2 diabetes .
12809451	0	Glimepiride	0,11	insulin	34,41	Glimepiride	insulin	MESH:C057619	3630	Chemical	Gene	START_ENTITY|advcl|glargine glargine|compound|END_ENTITY	Glimepiride combined with morning insulin glargine , bedtime neutral protamine hagedorn insulin , or bedtime insulin glargine in patients with type 2 diabetes .
15694373	0	Glimepiride	0,11	peroxisome_proliferator-activated_receptor-gamma	31,79	Glimepiride	peroxisome proliferator-activated receptor-gamma	MESH:C057619	5468	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|amod|END_ENTITY	Glimepiride enhances intrinsic peroxisome_proliferator-activated_receptor-gamma activity in 3T3-L1 adipocytes .
23278106	0	Gliotoxin	0,9	NOTCH2	22,28	Gliotoxin	NOTCH2	MESH:D005912	4853	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|compound|END_ENTITY	Gliotoxin is a potent NOTCH2 transactivation inhibitor and efficiently induces apoptosis in chronic_lymphocytic_leukaemia -LRB- CLL -RRB- cells .
1777653	4	Glipizide	1131,1140	insulin	1167,1174	Glipizide	insulin	MESH:D005913	3630	Chemical	Gene	augmented|nsubj|START_ENTITY augmented|dobj|response response|compound|END_ENTITY	Glipizide augmented the first-phase insulin response without changing the slope of the regression line relating plasma insulin to glucose concentrations .
6376145	0	Glipizide	0,9	insulin	27,34	Glipizide	insulin	MESH:D005913	3630	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Glipizide increases plasma insulin but not C-peptide level after a standardized breakfast in type 2 diabetic patients .
17292862	0	Gln	8,11	CYP27A1	24,31	Gln	CYP27A1	CHEBI:32668	1593	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of Gln 85 of human CYP27A1 in 25-hydroxyvitamin_D -LRB- 3 -RRB- - binding and protein folding .
23771542	4	Gln	715,718	SAP	704,707	Gln	Bax	CHEBI:32668	24887(Tax:10116)	Chemical	Gene	group|compound|START_ENTITY group|compound|END_ENTITY	MATERIALS AND METHODS : Eighty male SD rats were randomly divided into five groups : sham-operated group , SAP + parenteral_nutrition -LRB- PN -RRB- group , SAP + enteral nutrition -LRB- EN -RRB- group , SAP + EN + Gln group , and SAP + PN + Gln group .
15481890	0	Gln	30,33	alpha1	35,41	Gln	alpha1	CHEBI:32668	146	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|appos|END_ENTITY	Hb Buffalo -LSB- alpha89 -LRB- FG1 -RRB- His -- > Gln -LRB- alpha1 -RRB- -RSB- , observed solely and in the presence of an Hb S -LSB- beta6 -LRB- A3 -RRB- Glu -- > Val -RSB- heterozygosity .
12135568	0	Gln	13,16	myelin_basic_protein	46,66	Gln	myelin basic protein	CHEBI:32668	17196(Tax:10090)	Chemical	Gene	mutant|compound|START_ENTITY mutant|nmod|END_ENTITY	An Arg/Lys -- > Gln mutant of recombinant murine myelin_basic_protein as a mimic of the deiminated form implicated in multiple_sclerosis .
8097111	0	Glu	74,77	glutathione_reductase	96,117	Glu	glutathione reductase	CHEBI:18237	2936	Chemical	Gene	exchange|nsubj|START_ENTITY exchange|nmod|END_ENTITY	Folding of the four domains and dimerization are impaired by the Gly446 -- > Glu exchange in human glutathione_reductase .
1716370	0	Glu-His-Ile-Pro-Ala	12,31	fibrinogen	38,48	Glu-His-Ile-Pro-Ala	fibrinogen	MESH:C070903	2244	Chemical	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	The peptide Glu-His-Ile-Pro-Ala binds fibrinogen and inhibits platelet_aggregation and adhesion to fibrinogen and vitronectin .
11724637	0	Glucan_phosphate	0,16	interferon-gamma	47,63	Glucan phosphate	interferon-gamma	MESH:C480175	15978(Tax:10090)	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|expression expression|amod|END_ENTITY	Glucan_phosphate potentiates endotoxin-induced interferon-gamma expression in immunocompetent mice , but attenuates induction of endotoxin tolerance .
22829921	0	Glucopyranosyl_Lipid_Adjuvant	0,29	TLR4	49,53	Glucopyranosyl Lipid Adjuvant	TLR4	null	7099	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Glucopyranosyl_Lipid_Adjuvant -LRB- GLA -RRB- , a Synthetic TLR4 agonist , promotes potent systemic and mucosal responses to intranasal immunization with HIVgp140 .
17440993	0	Glucosamine	0,11	COX-2	33,38	Glucosamine	COX-2	MESH:D005944	19225(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Glucosamine inhibits LPS-induced COX-2 and iNOS expression in mouse macrophage cells -LRB- RAW 264.7 -RRB- by inhibition of p38-MAP kinase and transcription factor NF-kappaB .
22427561	0	Glucosamine	0,11	ICAM-1	36,42	Glucosamine	ICAM-1	MESH:D005944	3383	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|compound|END_ENTITY	Glucosamine modulates TNF-a-induced ICAM-1 expression and function through O-linked_and_N-linked_glycosylation in human retinal pigment epithelial cells .
19626664	0	Glucosamine	0,11	IL-8	39,43	Glucosamine	IL-8	MESH:D005944	3576	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	Glucosamine inhibits IL-1beta-mediated IL-8 production in prostate_cancer cells by MAPK attenuation .
12681956	0	Glucosamine	0,11	NFkappaB	38,46	Glucosamine	NFkappaB	MESH:D005944	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|compound|END_ENTITY	Glucosamine inhibits IL-1beta-induced NFkappaB activation in human osteoarthritic chondrocytes .
26852666	0	Glucosamine	0,11	REDD1	20,25	Glucosamine	REDD1	MESH:D005944	54541	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Glucosamine induces REDD1 to suppress insulin action in retinal M ller cells .
7926284	0	Glucosamine	0,11	glucokinase	21,32	Glucosamine	glucokinase	MESH:D005944	24385(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Glucosamine inhibits glucokinase in vitro and produces a glucose-specific impairment of in vivo insulin secretion in rats .
14768176	0	Glucosamine	1,12	insulin	84,91	Glucosamine	insulin	MESH:D005944	3630	Chemical	Gene	concentration|compound|START_ENTITY concentration|nmod|serum serum|nmod|persons persons|nmod|levels levels|compound|END_ENTITY	-LSB- Glucosamine concentration in serum of old persons with hyperinsulinemia and normal insulin levels -RSB- .
12746299	0	Glucosamine	0,11	insulin-like_growth_factor_I	34,62	Glucosamine	insulin-like growth factor I	MESH:D005944	3479	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Glucosamine induces resistance to insulin-like_growth_factor_I -LRB- IGF-I -RRB- and insulin in Hep G2 cell cultures : biological significance of IGF-I/insulin hybrid receptors .
18636175	0	Glucosamine	0,11	interleukin-8	23,36	Glucosamine	interleukin-8	MESH:D005944	3576	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|production production|amod|END_ENTITY	Glucosamine suppresses interleukin-8 production and ICAM-1 expression by TNF-alpha-stimulated human colonic epithelial HT-29 cells .
10905498	0	Glucosamine	0,11	plasminogen_activator_inhibitor_1	26,59	Glucosamine	plasminogen activator inhibitor 1	MESH:D005944	5054	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|promoter promoter|amod|END_ENTITY	Glucosamine activates the plasminogen_activator_inhibitor_1 gene promoter through Sp1 DNA binding sites in glomerular mesangial cells .
18804908	0	Glucosamine	0,11	transglutaminase_2	49,67	Glucosamine	transglutaminase 2	MESH:D005944	7052	Chemical	Gene	chemo-sensitizer|nsubj|START_ENTITY chemo-sensitizer|nmod|inhibition inhibition|amod|END_ENTITY	Glucosamine is an effective chemo-sensitizer via transglutaminase_2 inhibition .
17635918	0	Glucosamine_hydrochloride	0,25	COX-2	48,53	Glucosamine hydrochloride	COX-2	null	4513	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Glucosamine_hydrochloride specifically inhibits COX-2 by preventing COX-2 N-glycosylation and by increasing COX-2 protein turnover in a proteasome-dependent manner .
17238806	0	Glucosamine_sulfate	0,19	icam-1	62,68	Glucosamine sulfate	icam-1	MESH:D005944	3383	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Glucosamine_sulfate inhibits proinflammatory cytokine-induced icam-1 production in human conjunctival cells in vitro .
17970214	0	Glucosaminylmuramyl_dipeptide	0,29	tumor_necrosis_factor-alpha	57,84	Glucosaminylmuramyl dipeptide	tumor necrosis factor-alpha	MESH:C063429	7124	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|effects effects|nmod|END_ENTITY	Glucosaminylmuramyl_dipeptide potentiates the effects of tumor_necrosis_factor-alpha and cisplatin on transformed cells in vitro .
24237322	0	Glucose	0,7	ABA_INSENSITIVE_5	42,59	Glucose	ABA INSENSITIVE 5	MESH:D005947	818199(Tax:3702)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|growth growth|nmod|END_ENTITY	Glucose inhibits root meristem growth via ABA_INSENSITIVE_5 , which represses PIN1 accumulation and auxin activity in Arabidopsis .
25250787	0	Glucose	30,37	AMP-Activated_Protein_Kinase	87,115	Glucose	AMP-Activated Protein Kinase	MESH:D005947	5563	Chemical	Gene	Utilization|amod|START_ENTITY Increase|dobj|Utilization Increase|nmod|Activation Activation|nmod|END_ENTITY	Xanthene Derivatives Increase Glucose Utilization through Activation of LKB1-Dependent AMP-Activated_Protein_Kinase .
25756788	0	Glucose	110,117	AMP-Activated_Protein_Kinase	65,93	Glucose	AMP-Activated Protein Kinase	MESH:D005947	5563	Chemical	Gene	Uptake|compound|START_ENTITY Activity|dep|Uptake Activity|nmod|Regulation Regulation|nmod|END_ENTITY	Dibenzoylmethane Exerts Metabolic Activity through Regulation of AMP-Activated_Protein_Kinase -LRB- AMPK -RRB- - Mediated Glucose Uptake and Adipogenesis Pathways .
12829626	0	Glucose	0,7	AMP-activated_protein_kinase	68,96	Glucose	AMP-activated protein kinase	MESH:D005947	78975(Tax:10116)	Chemical	Gene	autoregulates|nsubj|START_ENTITY autoregulates|parataxis|involvement involvement|nmod|END_ENTITY	Glucose autoregulates its uptake in skeletal muscle : involvement of AMP-activated_protein_kinase .
15640157	0	Glucose	0,7	AMP-activated_protein_kinase	105,133	Glucose	AMP-activated protein kinase	MESH:D005947	5563	Chemical	Gene	deprivation|compound|START_ENTITY increases|nsubj|deprivation increases|nmod|activation activation|nmod|END_ENTITY	Glucose deprivation increases mRNA stability of vascular_endothelial_growth_factor through activation of AMP-activated_protein_kinase in DU145 prostate_carcinoma .
17551002	0	Glucose	0,7	AMPK	84,88	Glucose	AMPK	MESH:D005947	100145903(Tax:9823)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|process process|amod|END_ENTITY	Glucose stimulates protein synthesis in skeletal muscle of neonatal pigs through an AMPK - and mTOR-independent process .
18262491	0	Glucose	0,7	AMPK	85,89	Glucose	AMPK	MESH:D005947	78975(Tax:10116)	Chemical	Gene	deprivation|compound|START_ENTITY accelerates|nsubj|deprivation accelerates|nmod|activation activation|compound|END_ENTITY	Glucose deprivation accelerates VLDL_receptor-mediated TG-rich lipoprotein uptake by AMPK activation in skeletal muscle cells .
22359610	0	Glucose	0,7	AMPK	56,60	Glucose	AMPK	MESH:D005947	5563	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|leptin leptin|acl|signaling signaling|nmod|modulation modulation|nmod|activity activity|compound|END_ENTITY	Glucose enhances leptin signaling through modulation of AMPK activity .
23095119	4	Glucose	728,735	AMPK	746,750	Glucose	AMPK	MESH:D005947	78975(Tax:10116)	Chemical	Gene	decreased|nsubj|START_ENTITY decreased|ccomp|antagonistic antagonistic|nsubj|activity activity|compound|END_ENTITY	Glucose decreased AMPK activity and effects of palmitate and glucose on AMPK activity were antagonistic .
24240094	0	Glucose	0,7	AMPK	90,94	Glucose	AMPK	MESH:D005947	5563	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|metabolism metabolism|nmod|AMP-activated_kinase AMP-activated_kinase|appos|END_ENTITY	Glucose regulates hypothalamic long-chain fatty_acid metabolism via AMP-activated_kinase -LRB- AMPK -RRB- in neurons and astrocytes .
25683712	0	Glucose	78,85	AMPK	57,61	Glucose	AMPK	MESH:D005947	5562	Chemical	Gene	Deprivation|compound|START_ENTITY Activity|nmod|Deprivation Activity|compound|END_ENTITY	HIGD1A Regulates Oxygen Consumption , ROS Production , and AMPK Activity during Glucose Deprivation to Modulate Cell Survival and Tumor Growth .
25756788	0	Glucose	110,117	AMPK	95,99	Glucose	AMPK	MESH:D005947	5563	Chemical	Gene	Uptake|compound|START_ENTITY Activity|dep|Uptake Activity|nmod|Regulation Regulation|nmod|AMP-Activated_Protein_Kinase AMP-Activated_Protein_Kinase|appos|END_ENTITY	Dibenzoylmethane Exerts Metabolic Activity through Regulation of AMP-Activated_Protein_Kinase -LRB- AMPK -RRB- - Mediated Glucose Uptake and Adipogenesis Pathways .
25826445	0	Glucose	35,42	AMPK	79,83	Glucose	AMPK	MESH:D005947	5563	Chemical	Gene	Uptake|compound|START_ENTITY Uptake|nmod|Cells Cells|nmod|END_ENTITY	Irisin , a Novel Myokine , Regulates Glucose Uptake in Skeletal Muscle Cells via AMPK .
26071020	0	Glucose	0,7	AMPK	43,47	Glucose	AMPK	MESH:D005947	5563	Chemical	Gene	regulates|compound|START_ENTITY amyloid|nsubj|regulates amyloid|dobj|production production|nmod|END_ENTITY	Glucose regulates amyloid b production via AMPK .
26784927	0	Glucose	0,7	AMPK	47,51	Glucose	AMPK	MESH:D005947	5564	Chemical	Gene	Independent|compound|START_ENTITY Independent|nmod|Whereas Whereas|compound|END_ENTITY	Glucose Alters Per2 Rhythmicity Independent of AMPK , Whereas AMPK Inhibitor Compound_C Causes Profound Repression of Clock Genes and AgRP in mHypoE-37 Hypothalamic Neurons .
26784927	0	Glucose	0,7	AMPK	61,65	Glucose	AMPK	MESH:D005947	5564	Chemical	Gene	Independent|compound|START_ENTITY END_ENTITY|nsubj|Independent	Glucose Alters Per2 Rhythmicity Independent of AMPK , Whereas AMPK Inhibitor Compound_C Causes Profound Repression of Clock Genes and AgRP in mHypoE-37 Hypothalamic Neurons .
26830672	0	Glucose	30,37	AMPK	53,57	Glucose	AMPK	MESH:D005947	5563	Chemical	Gene	Production|compound|START_ENTITY Production|nmod|END_ENTITY	Geniposide Suppresses Hepatic Glucose Production via AMPK in HepG2 Cells .
6347193	0	Glucose	0,7	ATP_citrate_lyase	46,63	Glucose	ATP citrate lyase	MESH:D005947	24159(Tax:10116)	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Glucose - and insulin-independent induction of ATP_citrate_lyase in primary cultures of rat hepatocytes .
17785505	0	Glucose	0,7	Akt	89,92	Glucose	Akt	MESH:D005947	24185(Tax:10116)	Chemical	Gene	infusion|amod|START_ENTITY causes|nsubj|infusion causes|nmod|changes changes|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Glucose infusion causes insulin resistance in skeletal muscle of rats without changes in Akt and AS160 phosphorylation .
18394773	0	Glucose	0,7	Akt	89,92	Glucose	Akt	MESH:D005947	207	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|dep|activation activation|nmod|END_ENTITY	Glucose metabolism and angiogenesis in granulosa_cell_tumors of the ovary : activation of Akt , expression of M2PK , TKTL1 and VEGF .
21178318	0	Glucose	0,7	Akt	169,172	Glucose	Akt	MESH:D005947	24185(Tax:10116)	Chemical	Gene	uptake|amod|START_ENTITY increased|nsubjpass|uptake increased|nmod|current current|nmod|activation activation|nmod|END_ENTITY	Glucose uptake in rat skeletal muscle L6 cells is increased by low-intensity electrical current through the activation of the phosphatidylinositol-3-OH_kinase -LRB- PI-3K -RRB- / Akt pathway .
25247550	0	Glucose	15,22	Akt	53,56	Glucose	Akt	MESH:D005947	24185(Tax:10116)	Chemical	Gene	Metabolism|compound|START_ENTITY Metabolism|nmod|END_ENTITY	DMH1 Increases Glucose Metabolism through Activating Akt in L6 Rat Skeletal Muscle Cells .
25288788	0	Glucose	5,12	Akt	57,60	Glucose	Akt	MESH:D005947	11651(Tax:10090)	Chemical	Gene	Forces|nsubj|START_ENTITY Forces|dobj|Kinase Kinase|compound|END_ENTITY	High Glucose Forces a Positive Feed Back Loop Connecting Akt Kinase and FoxO1 to Activate mTORC1 for Mesangial Cell Hypertrophy and Matrix Protein Expression .
25621554	0	Glucose	28,35	Akt	124,127	Glucose	Akt	MESH:D005947	11651(Tax:10090)	Chemical	Gene	Proliferation|compound|START_ENTITY Concentrations|nmod|Proliferation Via|nsubj|Concentrations Via|dobj|Pathway Pathway|compound|END_ENTITY	Different Concentrations of Glucose Regulate Proliferation and Osteogenic Differentiation of Osteoblasts Via the PI3_Kinase / Akt Pathway .
25894669	0	Glucose	62,69	Akt	99,102	Glucose	Akt	MESH:D005947	207	Chemical	Gene	Uptake|compound|START_ENTITY Uptake|nmod|Activation Activation|nmod|END_ENTITY	Pentacyclic_Triterpenoids from Astilbe rivularis that Enhance Glucose Uptake via the Activation of Akt and Erk1/2 in C2C12 Myotubes .
25325797	0	Glucose	88,95	Angiopoietin-like_Protein_8	12,39	Glucose	Angiopoietin-like protein 8	MESH:D005947	624219(Tax:10090)	Chemical	Gene	Associated|nmod|START_ENTITY Associated|nsubj|END_ENTITY	Circulating Angiopoietin-like_Protein_8 Is Independently Associated With Fasting Plasma Glucose and Type_2_Diabetes_Mellitus .
26181633	0	Glucose	160,167	Angiotensin_II	0,14	Glucose	Angiotensin II	MESH:D005947	183	Chemical	Gene	Conditions|compound|START_ENTITY Cells|nmod|Conditions MircroRNA-145|nmod|Cells MircroRNA-145|nsubj|Downregulates Downregulates|compound|END_ENTITY	Angiotensin_II Downregulates MircroRNA-145 to Regulate Kruppel-like_Factor_4 and Myocardin Expression in Human Coronary Arterial Smooth Muscle Cells under High Glucose Conditions .
25948295	0	Glucose	35,42	BRAF	0,4	Glucose	BRAF	MESH:D005947	673	Chemical	Gene	Uptake|compound|START_ENTITY Uptake|compound|END_ENTITY	BRAF Inhibition Decreases Cellular Glucose Uptake in Melanoma in Association with Reduction in Cell Volume .
18156767	0	Glucose	110,117	C-Reactive_Protein	43,61	Glucose	C-Reactive Protein	MESH:D005947	1401	Chemical	Gene	Level|compound|START_ENTITY -LSB-|nmod|Level -LSB-|dobj|Relationship Relationship|nmod|END_ENTITY	-LSB- The Relationship between High Sensitivity C-Reactive_Protein and Metabolic Syndrome according to the Fasting Glucose Level at Medical Checkups . -RSB- .
24784714	0	Glucose	93,100	C-reactive_Protein	31,49	Glucose	C-reactive Protein	MESH:D005947	1401	Chemical	Gene	Tolerance|compound|START_ENTITY END_ENTITY|nmod|Tolerance	First-Trimester Maternal Serum C-reactive_Protein as a Predictor of Third-Trimester Impaired Glucose Tolerance .
24146103	0	Glucose	0,7	CD133	36,41	Glucose	CD133	MESH:D005947	8842	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Glucose transporter-1 expression in CD133 + laryngeal_carcinoma Hep-2 cells .
11433350	0	Glucose	45,52	CD36	77,81	Glucose	CD36	MESH:D005947	948	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	A link between diabetes and atherosclerosis : Glucose regulates expression of CD36 at the level of translation .
16126902	0	Glucose	0,7	CD4	68,71	Glucose	CD4	MESH:D005947	920	Chemical	Gene	expression|amod|START_ENTITY identifies|nsubj|expression identifies|dobj|population population|acl|cycling cycling|dobj|CD8 CD8|compound|END_ENTITY	Glucose transporter 1 expression identifies a population of cycling CD4 + CD8 + human thymocytes with high CXCR4-induced chemotaxis .
26608911	0	Glucose	0,7	CD4	34,37	Glucose	CD4	MESH:D005947	12504(Tax:10090)	Chemical	Gene	Oxidation|compound|START_ENTITY Critical|nsubjpass|Oxidation Critical|nmod|Activation Activation|compound|END_ENTITY	Glucose Oxidation Is Critical for CD4 + T Cell Activation in a Mouse Model of Systemic_Lupus_Erythematosus .
26832214	0	Glucose	20,27	CD44	12,16	Glucose	CD44	MESH:D005947	960	Chemical	Gene	Metabolism|compound|START_ENTITY Role|nmod|Metabolism Role|nmod|END_ENTITY	The Role of CD44 in Glucose Metabolism in Prostatic Small_Cell_Neuroendocrine_Carcinoma .
17416350	0	Glucose	0,7	CDK7	22,26	Glucose	CDK7	MESH:D005947	171150(Tax:10116)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Glucose regulation of CDK7 , a putative thiol related gene , in experimental diabetic_nephropathy .
3885954	0	Glucose	0,7	Ca2	28,31	Glucose	Ca2	MESH:D005947	54231(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|activity activity|amod|END_ENTITY	Glucose increases cytosolic Ca2 + activity in pancreatic islet cells .
16375857	0	Glucose	0,7	ChREBP	22,28	Glucose	ChREBP	MESH:D005947	51085	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Glucose activation of ChREBP in hepatocytes occurs via a two-step mechanism .
18591247	0	Glucose	0,7	ChREBP	18,24	Glucose	ChREBP	MESH:D005947	51085	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Glucose activates ChREBP by increasing its rate of nuclear entry and relieving repression of its transcriptional activity .
19660458	0	Glucose	0,7	ChREBP	46,52	Glucose	ChREBP	MESH:D005947	171078(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|compound|END_ENTITY	Glucose induces FGF21 mRNA expression through ChREBP activation in rat hepatocytes .
26181104	0	Glucose	4,11	ChREBP	19,25	Glucose	ChREBP	MESH:D005947	51085	Chemical	Gene	Novo|compound|START_ENTITY Novo|compound|END_ENTITY	The Glucose Sensor ChREBP Links De Novo Lipogenesis to PPARy Activity and Adipocyte Differentiation .
12746446	0	Glucose	0,7	Crk-associated_substrate	51,75	Glucose	Crk-associated substrate	MESH:D005947	25414(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Glucose stimulates the tyrosine phosphorylation of Crk-associated_substrate in pancreatic beta-cells .
26161955	0	Glucose	32,39	DAPIT	0,5	Glucose	DAPIT	MESH:D005947	84833	Chemical	Gene	Metabolism|compound|START_ENTITY Metabolism|compound|END_ENTITY	DAPIT Over-Expression Modulates Glucose Metabolism and Cell Behaviour in HEK293T Cells .
26469334	0	Glucose	44,51	DAPIT	12,17	Glucose	DAPIT	MESH:D005947	84833	Chemical	Gene	Metabolism|compound|START_ENTITY Metabolism|compound|END_ENTITY	Correction : DAPIT Over-Expression Modulates Glucose Metabolism and Cell Behaviour in HEK293T Cells .
26562021	0	Glucose	44,51	DAPIT	12,17	Glucose	DAPIT	MESH:D005947	84833	Chemical	Gene	Metabolism|compound|START_ENTITY Metabolism|compound|END_ENTITY	Correction : DAPIT Over-Expression Modulates Glucose Metabolism and Cell Behaviour in HEK293T Cells .
10064100	0	Glucose	0,7	Egr-1	44,49	Glucose	Egr-1	MESH:D005947	24330(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Glucose induces early growth response gene -LRB- Egr-1 -RRB- expression in pancreatic beta cells .
19660458	0	Glucose	0,7	FGF21	16,21	Glucose	FGF21	MESH:D005947	170580(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nummod|END_ENTITY	Glucose induces FGF21 mRNA expression through ChREBP activation in rat hepatocytes .
26439155	0	Glucose	86,93	FGF21	34,39	Glucose	FGF21	MESH:D005947	26291	Chemical	Gene	Control|compound|START_ENTITY Effect|nmod|Control Response|dep|Effect Response|compound|END_ENTITY	Letter to the Editor : Comment on `` FGF21 Response to Critical_Illness : Effect of Blood Glucose Control and Relation With Cellular Stress and Survival '' by Thiessen S.E. , et al. .
26858359	0	Glucose	66,73	Fgf21	42,47	Glucose	Fgf21	MESH:D005947	56636(Tax:10090)	Chemical	Gene	Homeostasis|compound|START_ENTITY Levels|nmod|Homeostasis Levels|nsubj|END_ENTITY	Dietary Betaine Supplementation Increases Fgf21 Levels to Improve Glucose Homeostasis and Reduce Hepatic Lipid Accumulation in Mice .
26052839	0	Glucose	107,114	FoxO1	27,32	Glucose	FoxO1	MESH:D005947	2308	Chemical	Gene	Conditions|compound|START_ENTITY Lentiviral|nmod|Conditions Lentiviral|dobj|Secretion Secretion|compound|END_ENTITY	Lentiviral Vector-Mediated FoxO1 Overexpression Inhibits Extracellular Matrix Protein Secretion under High Glucose Conditions in Mesangial Cells .
16731820	0	Glucose	0,7	Foxo1	18,23	Glucose	Foxo1	MESH:D005947	56458(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Glucose regulates Foxo1 through insulin_receptor signaling in the pancreatic islet beta-cell .
25576059	0	Glucose	86,93	Foxo1	47,52	Glucose	Foxo1	MESH:D005947	56458(Tax:10090)	Chemical	Gene	Regulates|dobj|START_ENTITY Regulates|nsubj|Differentially Differentially|compound|END_ENTITY	A Mutant Allele Encoding DNA-Binding-Deficient Foxo1 Differentially Regulates Hepatic Glucose and Lipid Metabolism .
1464667	0	Glucose	0,7	GAD65	38,43	Glucose	GAD65	MESH:D005947	2572	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Glucose regulation of the autoantigen GAD65 in human pancreatic islets .
14700554	0	Glucose	0,7	GH	70,72	Glucose	GH	MESH:D005947	2688	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|dep|year year|nmod|replacement replacement|compound|END_ENTITY	Glucose metabolism and visceral fat in GH_deficient adults : 1 year of GH replacement .
25538323	0	Glucose	151,158	GIP	64,67	Glucose	GIP	MESH:D005947	2695	Chemical	Gene	Tolerance|compound|START_ENTITY Effect|nmod|Tolerance Effect|nmod|Administrations Administrations|nmod|END_ENTITY	Effect of Exogenous Intravenous Administrations of GLP-1 and/or GIP on Circulating Pro-Atrial Natriuretic Peptide in Subjects With Different Stages of Glucose Tolerance .
26221611	0	Glucose	16,23	GIP	53,56	Glucose	GIP	MESH:D005947	2695	Chemical	Gene	Levels|compound|START_ENTITY Effects|nmod|Levels Effects|nmod|Responsiveness Responsiveness|compound|END_ENTITY	Effects of High Glucose Levels and Glycated Serum on GIP Responsiveness in the Pancreatic Beta Cell Line HIT-T15 .
26221611	0	Glucose	16,23	GIP	53,56	Glucose	GIP	MESH:D005947	2695	Chemical	Gene	Levels|compound|START_ENTITY Effects|nmod|Levels Effects|nmod|Responsiveness Responsiveness|compound|END_ENTITY	Effects of High Glucose Levels and Glycated Serum on GIP Responsiveness in the Pancreatic Beta Cell Line HIT-T15 .
15558323	0	Glucose	0,7	GLP-1	126,131	Glucose	GLP-1	MESH:D005947	24952(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|dep|effect effect|acl|counteracted counteracted|nmod|END_ENTITY	Glucose stimulates the expression and activities of nitric_oxide synthases in incubated rat islets : an effect counteracted by GLP-1 through the cyclic_AMP / PKA pathway .
19758106	0	Glucose	0,7	GLP-1	75,80	Glucose	GLP-1	MESH:D005947	100125288	Chemical	Gene	lowering|compound|START_ENTITY lowering|dep|analogues analogues|compound|END_ENTITY	Glucose lowering and anti-atherogenic effects of incretin-based therapies : GLP-1 analogues and DPP-4-inhibitors .
25538323	0	Glucose	151,158	GLP-1	51,56	Glucose	GLP-1	MESH:D005947	100125288	Chemical	Gene	Tolerance|compound|START_ENTITY Effect|nmod|Tolerance Effect|nmod|Administrations Administrations|nmod|GIP GIP|compound|END_ENTITY	Effect of Exogenous Intravenous Administrations of GLP-1 and/or GIP on Circulating Pro-Atrial Natriuretic Peptide in Subjects With Different Stages of Glucose Tolerance .
25677912	0	Glucose	23,30	GLP-1	0,5	Glucose	GLP-1	MESH:D005947	100125288	Chemical	Gene	Response|nmod|START_ENTITY Response|compound|END_ENTITY	GLP-1 Response to Oral Glucose Is Reduced in Prediabetes , Screen-Detected Type 2 Diabetes , and Obesity and Influenced by Sex : The ADDITION-PRO Study .
26225223	0	Glucose	109,116	GLP-1	17,22	Glucose	GLP-1	MESH:D005947	2641	Chemical	Gene	Model|compound|START_ENTITY Diabetes_Mellitus|nmod|Model Diabetes_Mellitus|nsubj|Effects Effects|nmod|Analog Analog|compound|END_ENTITY	The Effects of a GLP-1 Analog on Glucose Homeostasis in Type 2 Diabetes_Mellitus Quantified by an Integrated Glucose Insulin Model .
26225223	0	Glucose	33,40	GLP-1	17,22	Glucose	GLP-1	MESH:D005947	2641	Chemical	Gene	Homeostasis|compound|START_ENTITY Analog|nmod|Homeostasis Analog|compound|END_ENTITY	The Effects of a GLP-1 Analog on Glucose Homeostasis in Type 2 Diabetes_Mellitus Quantified by an Integrated Glucose Insulin Model .
26294437	1	Glucose	48,55	GLP-1	25,30	Glucose	GLP-1	MESH:D005947	100125288	Chemical	Gene	Response|nmod|START_ENTITY Response|compound|END_ENTITY	GLP-1 Response to Oral Glucose Is Reduced in Prediabetes , Screen-Detected Type 2 Diabetes , and Obesity and Influenced by Sex : The ADDITION-PRO Study .
26294438	1	Glucose	60,67	GLP-1	37,42	Glucose	GLP-1	MESH:D005947	100125288	Chemical	Gene	Response|nmod|START_ENTITY Response|compound|END_ENTITY	GLP-1 Response to Oral Glucose Is Reduced in Prediabetes , Screen-Detected Type 2 Diabetes , and Obesity and Influenced by Sex : The ADDITION-PRO Study .
26607841	0	Glucose	0,7	GLP-1	44,49	Glucose	GLP-1	MESH:D005947	100125288	Chemical	Gene	Variability|compound|START_ENTITY Variability|dep|Response Response|nmod|CSII CSII|compound|END_ENTITY	Glucose Variability and b - Cell Response by GLP-1 Analogue added-on CSII for Patients with Poorly Controlled Type 2 Diabetes .
1520263	0	Glucose	0,7	GLUT-1	101,107	Glucose	GLUT-1	MESH:D005947	6513	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|advcl|modulating modulating|dobj|trafficking trafficking|nmod|END_ENTITY	Glucose regulates its transport in L8 myocytes by modulating cellular trafficking of the transporter GLUT-1 .
17657332	0	Glucose	1,8	GLUT-1	49,55	Glucose	GLUT-1	MESH:D005947	6513	Chemical	Gene	transponer|nsubj|START_ENTITY transponer|ccomp|deficiency_s deficiency_s|dobj|ndrome ndrome|appos|SD SD|compound|END_ENTITY	-LSB- Glucose transponer type 1 deficiency_s __ ndrome -LRB- GLUT-1 SD -RRB- treated with ketogenic diet .
9124334	0	Glucose	0,7	GLUT-1	53,59	Glucose	GLUT-1	MESH:D005947	20525(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|proteins proteins|amod|END_ENTITY	Glucose utilization and glucose transporter proteins GLUT-1 and GLUT-3 in brains of diabetic -LRB- db/db -RRB- mice .
11171596	0	Glucose	0,7	GLUT-4	65,71	Glucose	GLUT-4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|acl|overexpressing overexpressing|dobj|transporter transporter|compound|END_ENTITY	Glucose metabolism in perfused mouse hearts overexpressing human GLUT-4 glucose transporter .
8770023	0	Glucose	0,7	GLUT-4	35,41	Glucose	GLUT-4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|protein protein|compound|END_ENTITY	Glucose transport and cell surface GLUT-4 protein in skeletal muscle of the obese Zucker rat .
10983690	0	Glucose	0,7	GLUT1	23,28	Glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY associated|nsubjpass|transporter associated|dep|END_ENTITY	Glucose transporter 1 -LRB- GLUT1 -RRB- expression is associated with intestinal type of gastric_carcinoma .
12234775	0	Glucose	0,7	GLUT1	39,44	Glucose	GLUT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	mediated|nsubj|START_ENTITY mediated|ccomp|decrease decrease|nsubj|infection infection|compound|END_ENTITY	Glucose uptake and adenoviral mediated GLUT1 infection decrease hypoxia-induced HIF-1alpha levels in cardiac myocytes .
1544434	0	Glucose	0,7	GLUT1	84,89	Glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	binding|compound|START_ENTITY enhances|nsubj|binding enhances|dobj|susceptibility susceptibility|nmod|loop loop|nmod|transporter transporter|compound|END_ENTITY	Glucose binding enhances the papain susceptibility of the intracellular loop of the GLUT1 glucose transporter .
16782269	0	Glucose	0,7	GLUT1	29,34	Glucose	GLUT1	MESH:D005947	443461(Tax:9940)	Chemical	Gene	proteins|amod|START_ENTITY proteins|acl:relcl|like like|nsubj|END_ENTITY	Glucose transporter proteins GLUT1 and GLUT3 like immunoreactivities in the fetal sheep brain are not reduced by maternal betamethasone treatment .
17405828	10	Glucose	959,966	GLUT1	983,988	Glucose	GLUT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	transport|amod|START_ENTITY transporters|nsubj|transport transporters|compound|END_ENTITY	Glucose transport is by GLUT1 and GLUT4 transporters in 3T3-L1 adipocyte and by the GLUT1 transporter in Clone 9 cells .
19465749	0	Glucose	0,7	GLUT1	20,25	Glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Glucose transporter GLUT1 expression is an stage-independent predictor of clinical outcome in adrenocortical_carcinoma .
20558154	0	Glucose	0,7	GLUT1	71,76	Glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|up-regulation up-regulation|nmod|gene gene|nummod|END_ENTITY	Glucose metabolism activation by SHIP2 inhibitors via up-regulation of GLUT1 gene in L6 myotubes .
23336592	0	Glucose	0,7	GLUT1	162,167	Glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	metabolism|amod|START_ENTITY down-regulates|nsubj|metabolism down-regulates|dobj|uptake uptake|dep|-2 -2|dep|model model|amod|mediated mediated|nmod|glucose_transporter_1_isoform glucose_transporter_1_isoform|appos|END_ENTITY	Glucose metabolism down-regulates the uptake of 6 - -LRB- N - -LRB- 7-nitrobenz-2-oxa-1 ,3 - diazol-4-yl -RRB- amino -RRB- -2 - deoxyglucose -LRB- 6-NBDG -RRB- mediated by glucose_transporter_1_isoform -LRB- GLUT1 -RRB- : theory and simulations using the symmetric four-state carrier model .
25339765	0	Glucose	81,88	GLUT1	109,114	Glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	Type|compound|START_ENTITY Type|appos|END_ENTITY	Separate Cellular Localizations of Human_T-Lymphotropic_Virus_1 -LRB- HTLV-1 -RRB- Env and Glucose Transporter Type 1 -LRB- GLUT1 -RRB- Are Required for HTLV-1 Env-Mediated Fusion and Infection .
25385184	0	Glucose	0,7	GLUT1	74,79	Glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	uptake|amod|START_ENTITY dependent|nsubj|uptake dependent|nmod|translocation translocation|compound|END_ENTITY	Glucose uptake in brown fat cells is dependent on mTOR complex 2-promoted GLUT1 translocation .
25982116	0	Glucose	58,65	GLUT1	44,49	Glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	Transport|compound|START_ENTITY Transport|compound|END_ENTITY	A Protein Kinase C Phosphorylation Motif in GLUT1 Affects Glucose Transport and is Mutated in GLUT1 Deficiency Syndrome .
26821218	0	Glucose	27,34	GLUT1	57,62	Glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	Transport|compound|START_ENTITY Study|nmod|Transport Mediated|nsubj|Study Mediated|nmod|END_ENTITY	Mechanistic Study of Human Glucose Transport Mediated by GLUT1 .
26886772	0	Glucose	49,56	GLUT1	43,48	Glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	Transporter|compound|START_ENTITY Transporter|compound|END_ENTITY	Prolactin-induced Subcellular Targeting of GLUT1 Glucose Transporter in Living Mammary Epithelial Cells .
8034582	0	Glucose	0,7	GLUT1	83,88	Glucose	GLUT1	MESH:D005947	20525(Tax:10090)	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Glucose transport activity in skeletal muscles from transgenic_mice overexpressing GLUT1 .
8147898	0	Glucose	0,7	GLUT1	20,25	Glucose	GLUT1	MESH:D005947	20525(Tax:10090)	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Glucose transporter GLUT1 mRNA expression in the ontogeny of glucose incorporation in mouse preimplantation embryos .
8216230	0	Glucose	0,7	GLUT1	140,145	Glucose	GLUT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	transporters|amod|START_ENTITY transporters|dep|stimulation stimulation|nmod|END_ENTITY	Glucose transporters and in vivo glucose uptake in skeletal and cardiac muscle : fasting , insulin stimulation and immunoisolation studies of GLUT1 and GLUT4 .
8369652	0	Glucose	0,7	GLUT1	92,97	Glucose	GLUT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	stimulation|amod|START_ENTITY stimulation|dep|role role|nmod|transcription transcription|compound|END_ENTITY	Glucose transport stimulation by thyroid_hormone in ARL_15 cells : partial role of increased GLUT1 glucose transporter gene transcription .
8408071	0	Glucose	0,7	GLUT1	49,54	Glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transport|amod|START_ENTITY myoblasts|nsubj|transport myoblasts|xcomp|overexpressing overexpressing|dobj|END_ENTITY	Glucose transport in L6 myoblasts overexpressing GLUT1 and GLUT4 .
8452538	0	Glucose	0,7	GLUT1	193,198	Glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	activity|amod|START_ENTITY activity|dep|forskolin forskolin|nmod|END_ENTITY	Glucose transport activity and photolabelling with 3 - -LSB- 125I -RSB- iodo-4-azidophenethylamido-7-O-succinyldeacetyl -LRB- IAPS -RRB- - forskolin of two mutants at tryptophan-388 and -412 of the glucose transporter GLUT1 : dissociation of the binding domains of forskolin and glucose .
8969278	0	Glucose	0,7	GLUT1	70,75	Glucose	GLUT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	transporters|amod|START_ENTITY transporters|dep|expression expression|nmod|END_ENTITY	Glucose transporters in rat peripheral nerve : paranodal expression of GLUT1 and GLUT3 .
9228080	0	Glucose	0,7	GLUT1	29,34	Glucose	GLUT1	MESH:D005947	100753506	Chemical	Gene	transporter|compound|START_ENTITY isoforms|nsubj|transporter isoforms|ccomp|transport transport|nsubj|END_ENTITY	Glucose transporter isoforms GLUT1 and GLUT3 transport dehydroascorbic_acid .
9855361	0	Glucose	0,7	GLUT1	20,25	Glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	localization|amod|START_ENTITY localization|compound|END_ENTITY	Glucose transporter GLUT1 localization in human foetus telencephalon .
9140080	0	Glucose	0,7	GLUT2	34,39	Glucose	GLUT2	MESH:D005947	25351(Tax:10116)	Chemical	Gene	correlates|amod|START_ENTITY correlates|nmod|END_ENTITY	Glucose transport correlates with GLUT2 abundance in rat liver during altered thyroid status .
26086828	0	Glucose	38,45	GLUT3	32,37	Glucose	GLUT3	MESH:D005947	6515	Chemical	Gene	Transporter|compound|START_ENTITY Transporter|compound|END_ENTITY	Regulation of Human Trophoblast GLUT3 Glucose Transporter by Mammalian Target of Rapamycin Signaling .
10403566	0	Glucose	0,7	GLUT4	42,47	Glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|content content|compound|END_ENTITY	Glucose rapidly decreases plasma membrane GLUT4 content in rat skeletal muscle .
21740425	0	Glucose	0,7	GLUT4	21,26	Glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	transporters|nsubj|START_ENTITY transporters|ccomp|upregulated upregulated|nsubjpass|END_ENTITY	Glucose transporters GLUT4 and GLUT8 are upregulated after facial_nerve_axotomy in adult mice .
25561724	0	Glucose	62,69	GLUT4	56,61	Glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	Transporters|compound|START_ENTITY Transporters|compound|END_ENTITY	Acetylation of TUG Protein Promotes the Accumulation of GLUT4 Glucose Transporters in an Insulin-responsive Intracellular Compartment .
25647228	0	Glucose	181,188	GLUT4	225,230	Glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	Uptake|compound|START_ENTITY Uptake|nmod|Transporters Transporters|compound|END_ENTITY	Aqueous Fraction of Beta vulgaris Ameliorates Hyperglycemia in Diabetic Mice due to Enhanced Glucose Stimulated Insulin Secretion , Mediated by Acetylcholine and GLP-1 , and Elevated Glucose Uptake via Increased Membrane Bound GLUT4 Transporters .
26286522	0	Glucose	0,7	GLUT4	55,60	Glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	uptake|nsubj|START_ENTITY uptake|nmod|translocation translocation|nmod|END_ENTITY	Glucose uptake through translocation and activation of GLUT4 in PI3K/Akt signaling pathway by asiatic_acid in diabetic rats .
26503060	0	Glucose	49,56	GLUT4	106,111	Glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	Metabolism|compound|START_ENTITY Effect|nmod|Metabolism Effect|dep|Involvement Involvement|nmod|Expression Expression|nmod|END_ENTITY	Effect of Intermittent Hypoxia and Rimonabant on Glucose Metabolism in Rats : Involvement of Expression of GLUT4 in Skeletal Muscle .
26951104	0	Glucose	60,67	GLUT4	54,59	Glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	Transporter|compound|START_ENTITY Transporter|compound|END_ENTITY	Metabolic Control of Type 2 Diabetes by Targeting the GLUT4 Glucose Transporter : Intervention Approaches .
8546674	0	Glucose	0,7	GLUT4	71,76	Glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	transport|amod|START_ENTITY transport|nmod|muscle muscle|nmod|END_ENTITY	Glucose transport and GLUT4 protein distribution in skeletal muscle of GLUT4 transgenic_mice .
8690151	0	Glucose	0,7	GLUT4	25,30	Glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	ingestion|compound|START_ENTITY causes|nsubj|ingestion causes|dobj|translocation translocation|nummod|END_ENTITY	Glucose ingestion causes GLUT4 translocation in human skeletal muscle .
14994344	0	Glucose	0,7	GLUT8	20,25	Glucose	GLUT8	MESH:D005947	56017(Tax:10090)	Chemical	Gene	translocation|amod|START_ENTITY translocation|compound|END_ENTITY	Glucose transporter GLUT8 translocation in neurons is not insulin responsive .
17226116	0	Glucose	0,7	GLUT8	20,25	Glucose	GLUT8	MESH:D005947	29988	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Glucose transporter GLUT8 mRNA expression in intestinal Caco-2 cells is regulated by growth and metabolism .
22840238	0	Glucose	0,7	GLUT_4	74,80	Glucose	GLUT 4	MESH:D005947	6517	Chemical	Gene	uptake|nsubj|START_ENTITY uptake|dobj|effect effect|nmod|cells cells|amod|4-hydroxypipecolic_acid 4-hydroxypipecolic_acid|nmod|translocation translocation|compound|END_ENTITY	Glucose uptake stimulatory effect of 4-hydroxypipecolic_acid by increased GLUT_4 translocation in skeletal muscle cells .
21267538	0	Glucose	0,7	GMRP1	38,43	Glucose	GMRP1	MESH:D005947	68815(Tax:10090)	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Glucose metabolism-related protein 1 -LRB- GMRP1 -RRB- regulates pancreatic beta cell proliferation and apoptosis via activation of Akt signalling pathway in rats and mice .
9792193	0	Glucose	0,7	GRP78	22,27	Glucose	GRP78	MESH:D005947	14828(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|regulation regulation|nmod|expression expression|compound|END_ENTITY	Glucose regulation of GRP78 gene expression .
25288673	0	Glucose	109,116	Glucagon-like_Peptide-1_Receptor	62,94	Glucose	Glucagon-like Peptide-1 Receptor	MESH:D005947	14652(Tax:10090)	Chemical	Gene	Production|compound|START_ENTITY END_ENTITY|nmod|Production	Absence of Glucagon and Insulin Action Reveals a Role for the Glucagon-like_Peptide-1_Receptor in Endogenous Glucose Production .
26020795	0	Glucose	66,73	Glucagon_Receptor	0,17	Glucose	Glucagon Receptor	MESH:D005947	14527(Tax:10090)	Chemical	Gene	Blockade|nmod|START_ENTITY Blockade|compound|END_ENTITY	Glucagon_Receptor Blockade With a Human Antibody Normalizes Blood Glucose in Diabetic Mice and Monkeys .
24294411	0	Glucose	76,83	Glucokinase	46,57	Glucose	Glucokinase	MESH:D005947	2645	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Small-Molecule Allosteric Activation of Human Glucokinase in the Absence of Glucose .
11888207	0	Glucose	0,7	Glut-1	98,104	Glucose	Glut-1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	uptake|nsubj|START_ENTITY uptake|xcomp|overexpressing overexpressing|dobj|transporter transporter|compound|END_ENTITY	Glucose uptake and lactate production in cells exposed to CoCl -LRB- 2 -RRB- and in cells overexpressing the Glut-1 glucose transporter .
25596527	0	Glucose	62,69	Glut4	104,109	Glucose	Glut4	MESH:D005947	6517	Chemical	Gene	Uptake|compound|START_ENTITY Uptake|appos|END_ENTITY	Zinc_Finger_Protein_407 -LRB- ZFP407 -RRB- Regulates Insulin-stimulated Glucose Uptake and Glucose Transporter 4 -LRB- Glut4 -RRB- mRNA .
9383041	0	Glucose	0,7	Glut_5	20,26	Glucose	Glut 5	MESH:D005947	6518	Chemical	Gene	START_ENTITY|dobj|expression expression|amod|END_ENTITY	Glucose transporter Glut_5 expression in microglial cells .
25532036	0	Glucose	18,25	Growth_Hormone	74,88	Glucose	Growth Hormone	MESH:D005947	2688	Chemical	Gene	Use|nmod|START_ENTITY Monitoring|nsubj|Use Monitoring|nmod|Dysregulation Dysregulation|nmod|Syndrome Syndrome|compound|END_ENTITY	Use of Continuous Glucose Monitoring to Identify Glucose Dysregulation in Growth_Hormone Insensitivity Syndrome .
25532036	0	Glucose	49,56	Growth_Hormone	74,88	Glucose	Growth Hormone	MESH:D005947	2688	Chemical	Gene	Dysregulation|compound|START_ENTITY Dysregulation|nmod|Syndrome Syndrome|compound|END_ENTITY	Use of Continuous Glucose Monitoring to Identify Glucose Dysregulation in Growth_Hormone Insensitivity Syndrome .
8967474	0	Glucose	0,7	HC9	53,56	Glucose	HC9	MESH:D005947	15158(Tax:10090)	Chemical	Gene	metabolism|amod|START_ENTITY END_ENTITY|nsubj|metabolism	Glucose metabolism and insulin release in mouse beta HC9 cells , as model for wild-type pancreatic beta-cells .
18266932	0	Glucose	0,7	HIF-1_alpha	21,32	Glucose	HIF-1 alpha	MESH:D005947	29560(Tax:10116)	Chemical	Gene	up-regulates|amod|START_ENTITY END_ENTITY|nsubj|up-regulates	Glucose up-regulates HIF-1_alpha expression in primary cortical neurons in response to hypoxia through maintaining cellular redox status .
26175156	0	Glucose	5,12	HIF-1a	41,47	Glucose	HIF-1a	MESH:D005947	29560(Tax:10116)	Chemical	Gene	ADAM17|compound|START_ENTITY ADAM17|nmod|END_ENTITY	High Glucose Up-regulates ADAM17 through HIF-1a in Mesangial Cells .
26339797	0	Glucose	56,63	HIF-1a	24,30	Glucose	HIF-1a	MESH:D005947	3091	Chemical	Gene	Treatment|compound|START_ENTITY Combined|nmod|Treatment Combined|nsubj|Effect Effect|nmod|Inhibition Inhibition|compound|END_ENTITY	The Apoptotic Effect of HIF-1a Inhibition Combined with Glucose plus Insulin Treatment on Gastric_Cancer under Hypoxic Conditions .
25593311	0	Glucose	45,52	Hexokinase	107,117	Glucose	Hexokinase	MESH:D005947	851167(Tax:4932)	Chemical	Gene	Signaling|compound|START_ENTITY Signaling|nmod|Saccharomyces_cerevisiae Saccharomyces_cerevisiae|nmod|Level Level|nmod|Phosphorylation Phosphorylation|compound|END_ENTITY	Protein Kinase Ymr291w/Tda1 Is Essential for Glucose Signaling in Saccharomyces_cerevisiae on the Level of Hexokinase Isoenzyme ScHxk2 Phosphorylation * .
18818743	0	Glucose	9,16	HuH-7	55,60	Glucose	HuH-7	MESH:D005947	284424	Chemical	Gene	Requirement|compound|START_ENTITY Requirement|nmod|END_ENTITY	Enhanced Glucose Requirement in Human Hepatoma-derived HuH-7 Cells by Forced Expression of the bcl-2 Gene .
24821015	0	Glucose	0,7	Hxt1	69,73	Glucose	Hxt1	MESH:D005947	856494(Tax:4932)	Chemical	Gene	turnover|amod|START_ENTITY glucose|nsubj|turnover glucose|dobj|END_ENTITY	Glucose starvation-induced turnover of the yeast glucose transporter Hxt1 .
25816250	0	Glucose	10,17	Hxt1	65,69	Glucose	Hxt1	MESH:D005947	856494(Tax:4932)	Chemical	Gene	Uptake|compound|START_ENTITY Assessing|dobj|Uptake Assessing|nmod|Hexose_Transporter_1 Hexose_Transporter_1|appos|END_ENTITY	Assessing Glucose Uptake through the Yeast Hexose_Transporter_1 -LRB- Hxt1 -RRB- .
10708553	0	Glucose	0,7	IGF-I	27,32	Glucose	IGF-I	MESH:D005947	24482(Tax:10116)	Chemical	Gene	starvation|compound|START_ENTITY reduces|nsubj|starvation reduces|dobj|mRNA mRNA|amod|END_ENTITY	Glucose starvation reduces IGF-I mRNA in tumor cells : evidence for an effect on mRNA stability .
26331550	0	Glucose	53,60	IGF-I	7,12	Glucose	IGF-I	MESH:D005947	3479	Chemical	Gene	Diabetes|compound|START_ENTITY Measured|nmod|Diabetes Measured|nsubj|END_ENTITY	Tissue IGF-I Measured by Microdialysis Reflects Body Glucose Utilization After rhIGF-I Injection in Type 1 Diabetes .
7828554	0	Glucose	0,7	IGF-I	19,24	Glucose	IGF-I	MESH:D005947	3479	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Glucose stimulates IGF-I gene expression in C6 glioma cells .
12037718	0	Glucose	0,7	INS-1	27,32	Glucose	INS-1	MESH:D005947	2305	Chemical	Gene	desensitization|amod|START_ENTITY desensitization|nmod|cells cells|compound|END_ENTITY	Glucose desensitization in INS-1 cells : evidence of impaired function caused by glucose metabolite -LRB- s -RRB- rather than by the glucose molecule per se .
19672815	0	Glucose	0,7	INS-1	95,100	Glucose	INS-1	MESH:D005947	2305	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|nmod|cell cell|compound|END_ENTITY	Glucose , metformin , and AICAR regulate the expression of G protein-coupled receptor members in INS-1 beta cell .
20532020	0	Glucose	14,21	INS-1	63,68	Glucose	INS-1	MESH:D005947	2305	Chemical	Gene	Fluctuation|compound|START_ENTITY Effect|nmod|Fluctuation Effect|nmod|Cells Cells|compound|END_ENTITY	The Effect of Glucose Fluctuation on Apoptosis and Function of INS-1 Pancreatic Beta Cells .
25310693	0	Glucose	96,103	INS-1	64,69	Glucose	INS-1	MESH:D005947	2305	Chemical	Gene	Dependence|nmod|START_ENTITY Dependence|nmod|Beta-Cells Beta-Cells|compound|END_ENTITY	Cytoskeletal Dependence of Insulin Granule Movement Dynamics in INS-1 Beta-Cells in Response to Glucose .
8103051	0	Glucose	0,7	INS-1	89,94	Glucose	INS-1	MESH:D005947	2305	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|line line|appos|END_ENTITY	Glucose regulates acetyl-CoA carboxylase gene expression in a pancreatic beta-cell line -LRB- INS-1 -RRB- .
10542398	0	Glucose	50,57	Insulin	72,79	Glucose	Insulin	MESH:D005947	3630	Chemical	Gene	Metabolism|compound|START_ENTITY Metabolism|nmod|END_ENTITY	Spatial Compartmentalization in the Regulation of Glucose Metabolism by Insulin .
18823654	0	Glucose	0,7	Insulin	45,52	Glucose	Insulin	MESH:D005947	3630	Chemical	Gene	homeostasis|amod|START_ENTITY homeostasis|dep|resistance resistance|amod|END_ENTITY	Glucose homeostasis during canine pregnancy : Insulin resistance , ketosis , and hypoglycemia .
20148062	0	Glucose	32,39	Insulin	96,103	Glucose	Insulin	MESH:D005947	3630	Chemical	Gene	Data|compound|START_ENTITY Analysis|nmod|Data Analysis|nmod|Sensitivity Sensitivity|compound|END_ENTITY	DISTq : An Iterative Analysis of Glucose Data for Low-Cost , Real-Time and Accurate Estimation of Insulin Sensitivity .
22187651	0	Glucose	68,75	Insulin	88,95	Glucose	Insulin	MESH:D005947	3630	Chemical	Gene	Lowering|compound|START_ENTITY Lowering|nmod|Glargine Glargine|compound|END_ENTITY	Effects of Selected Anionic_b-Cyclodextrins on Persistence of Blood Glucose Lowering by Insulin Glargine after Subcutaneous Injection to Rats .
22567007	0	Glucose	19,26	Insulin	71,78	Glucose	Insulin	MESH:D005947	3630	Chemical	Gene	START_ENTITY|nmod|Deterioration Deterioration|nmod|Secretion Secretion|compound|END_ENTITY	1-Hour OGTT Plasma Glucose as a Marker of Progressive Deterioration of Insulin Secretion and Action in Pregnant Women .
22736405	0	Glucose	33,40	Insulin	72,79	Glucose	Insulin	MESH:D005947	3630	Chemical	Gene	Cost|nmod|START_ENTITY Cost|nmod|Patients Patients|nmod|Regimen Regimen|compound|END_ENTITY	Cost of Self-Monitoring of Blood Glucose in Canada among Patients on an Insulin Regimen for Diabetes .
23805253	0	Glucose	120,127	Insulin	53,60	Glucose	Insulin	MESH:D005947	3630	Chemical	Gene	Expression|compound|START_ENTITY Myotubes|nmod|Expression Resistance|nmod|Myotubes Resistance|amod|END_ENTITY	Lifelong Physical Activity Prevents Aging-Associated Insulin Resistance in Human Skeletal Muscle Myotubes via Increased Glucose Transporter Expression .
24876556	0	Glucose	15,22	Insulin	50,57	Glucose	Insulin	MESH:D005947	3630	Chemical	Gene	System|compound|START_ENTITY Use|nmod|System Use|nmod|Dosing Dosing|compound|END_ENTITY	Use of a Smart Glucose Monitoring System to Guide Insulin Dosing in Patients With Diabetes in Regular Clinical Practice .
24876557	0	Glucose	28,35	Insulin	62,69	Glucose	Insulin	MESH:D005947	3630	Chemical	Gene	Use|nmod|START_ENTITY Monitoring|dep|Use Monitoring|nmod|Patients Patients|nmod|Therapy Therapy|compound|END_ENTITY	Use of Real-Time Continuous Glucose Monitoring in Patients on Insulin Pump Therapy : Real-Life Experience in an Endocrinology Office .
24876621	0	Glucose	4,11	Insulin	64,71	Glucose	Insulin	MESH:D005947	3630	Chemical	Gene	Accurately|nsubj|START_ENTITY Accurately|nmod|Site Site|nmod|Delivery Delivery|compound|END_ENTITY	Can Glucose Be Monitored Accurately at the Site of Subcutaneous Insulin Delivery ?
25310693	0	Glucose	96,103	Insulin	27,34	Glucose	Insulin	MESH:D005947	3630	Chemical	Gene	Dependence|nmod|START_ENTITY Dependence|nmod|Dynamics Dynamics|compound|END_ENTITY	Cytoskeletal Dependence of Insulin Granule Movement Dynamics in INS-1 Beta-Cells in Response to Glucose .
25323013	0	Glucose	76,83	Insulin	23,30	Glucose	Insulin	MESH:D005947	3630	Chemical	Gene	Secondary|xcomp|START_ENTITY Secondary|nsubj|Impact Impact|nmod|Therapy Therapy|compound|END_ENTITY	The Negative Impact of Insulin Therapy for Acute Hyperglycemia Secondary to Glucose Load on Plasma Amino_Acid Profiles in a Rat Model of Sepsis .
25792745	0	Glucose	70,77	Insulin	0,7	Glucose	Insulin	MESH:D005947	3630	Chemical	Gene	Modulate|dobj|START_ENTITY Modulate|nsubj|END_ENTITY	Insulin and Insulin-like_Growth_Factor_1 -LRB- IGF-1 -RRB- Modulate Cytoplasmic Glucose and Glycogen Levels but Not Glucose Transport across the Membrane in Astrocytes .
25897187	0	Glucose	72,79	Insulin	47,54	Glucose	Insulin	MESH:D005947	3630	Chemical	Gene	Control|compound|START_ENTITY END_ENTITY|nmod|Control	Adding GLP-1_Receptor Agonist Therapy to Basal Insulin for Postprandial Glucose Control .
25918231	0	Glucose	32,39	Insulin	63,70	Glucose	Insulin	MESH:D005947	3630	Chemical	Gene	START_ENTITY|dep|Secretion Secretion|compound|END_ENTITY	Toll-Like_Receptor_3 Influences Glucose Homeostasis And b-Cell Insulin Secretion .
25918231	0	Glucose	32,39	Insulin	63,70	Glucose	Insulin	MESH:D005947	3630	Chemical	Gene	START_ENTITY|dep|Secretion Secretion|compound|END_ENTITY	Toll-Like_Receptor_3 Influences Glucose Homeostasis And b-Cell Insulin Secretion .
26214150	0	Glucose	48,55	Insulin	15,22	Glucose	Insulin	MESH:D005947	3630	Chemical	Gene	Uptake|compound|START_ENTITY Resistance|nmod|Uptake Resistance|nsubj|Association Association|nmod|END_ENTITY	Association of Insulin Resistance With Cerebral Glucose Uptake in Late Middle-Aged Adults at Risk for Alzheimer_Disease .
26225223	0	Glucose	109,116	Insulin	117,124	Glucose	Insulin	MESH:D005947	3630	Chemical	Gene	Model|compound|START_ENTITY Model|compound|END_ENTITY	The Effects of a GLP-1 Analog on Glucose Homeostasis in Type 2 Diabetes_Mellitus Quantified by an Integrated Glucose Insulin Model .
26225223	0	Glucose	33,40	Insulin	117,124	Glucose	Insulin	MESH:D005947	3630	Chemical	Gene	Homeostasis|compound|START_ENTITY Analog|nmod|Homeostasis Effects|nmod|Analog Diabetes_Mellitus|nsubj|Effects Diabetes_Mellitus|nmod|Model Model|compound|END_ENTITY	The Effects of a GLP-1 Analog on Glucose Homeostasis in Type 2 Diabetes_Mellitus Quantified by an Integrated Glucose Insulin Model .
26360670	0	Glucose	25,32	Insulin	0,7	Glucose	Insulin	MESH:D005947	3630	Chemical	Gene	Control|nmod|START_ENTITY Control|compound|END_ENTITY	Insulin Control of Blood Glucose and GLUT4 Expression in the Skeletal Muscle of Septic Rats .
26487791	0	Glucose	55,62	Insulin	105,112	Glucose	Insulin	MESH:D005947	3630	Chemical	Gene	Management|nmod|START_ENTITY Options|nmod|Management Diabetes|nsubj|Options Diabetes|nmod|END_ENTITY	Therapeutic Options for the Management of Postprandial Glucose in Patients With Type 2 Diabetes on Basal Insulin .
26587020	0	Glucose	48,55	Insulin	157,164	Glucose	Insulin	MESH:D005947	3630	Chemical	Gene	Self-Monitoring|nmod|START_ENTITY Self-Monitoring|nmod|Patients Patients|nmod|Type_2_Diabetes_Treated Type_2_Diabetes_Treated|nmod|END_ENTITY	Four-Point Preprandial Self-Monitoring of Blood Glucose for the Assessment of Glycemic Control and Variability in Patients with Type_2_Diabetes_Treated with Insulin and Vildagliptin .
26623647	0	Glucose	0,7	Insulin	25,32	Glucose	Insulin	MESH:D005947	3630	Chemical	Gene	Law|compound|START_ENTITY Law|dep|Predicts Predicts|compound|END_ENTITY	Glucose Homeostatic Law : Insulin Clearance Predicts the Progression of Glucose Intolerance in Humans .
26623647	0	Glucose	71,78	Insulin	25,32	Glucose	Insulin	MESH:D005947	3630	Chemical	Gene	Intolerance|compound|START_ENTITY Progression|nmod|Intolerance Predicts|dep|Progression Predicts|compound|END_ENTITY	Glucose Homeostatic Law : Insulin Clearance Predicts the Progression of Glucose Intolerance in Humans .
26625003	0	Glucose	12,19	Insulin	178,185	Glucose	Insulin	MESH:D005947	3630	Chemical	Gene	Levels|compound|START_ENTITY Diabetic|nsubj|Levels Diabetic|dobj|Therapy Therapy|compound|END_ENTITY	Can Fasting Glucose Levels or Post-Breakfast Glucose Fluctuations Predict the Occurrence of Nocturnal Asymptomatic Hypoglycemia in Type 1 Diabetic Patients Receiving Basal-Bolus Insulin Therapy with Long-Acting Insulin ?
26625003	0	Glucose	12,19	Insulin	211,218	Glucose	Insulin	MESH:D005947	3630	Chemical	Gene	Levels|compound|START_ENTITY Diabetic|nsubj|Levels Diabetic|dobj|Therapy Therapy|nmod|END_ENTITY	Can Fasting Glucose Levels or Post-Breakfast Glucose Fluctuations Predict the Occurrence of Nocturnal Asymptomatic Hypoglycemia in Type 1 Diabetic Patients Receiving Basal-Bolus Insulin Therapy with Long-Acting Insulin ?
26646072	0	Glucose	61,68	Insulin	93,100	Glucose	Insulin	MESH:D005947	3630	Chemical	Gene	Therapy|compound|START_ENTITY Therapy|compound|END_ENTITY	Cost-Effectiveness of Sensor-Augmented Pump Therapy with Low Glucose Suspend Versus Standard Insulin Pump Therapy in Two Different Patient Populations with Type 1 Diabetes in France .
26650926	0	Glucose	15,22	Insulin	107,114	Glucose	Insulin	MESH:D005947	3630	Chemical	Gene	Hypometabolism|compound|START_ENTITY Hypometabolism|dep|Link Link|nmod|Resistance Resistance|compound|END_ENTITY	Regional Brain Glucose Hypometabolism in Young Women with Polycystic_Ovary_Syndrome : Possible Link to Mild Insulin Resistance .
26721672	0	Glucose	36,43	Insulin	0,7	Glucose	Insulin	MESH:D005947	3630	Chemical	Gene	Homeostasis|compound|START_ENTITY Signaling|nmod|Homeostasis Signaling|compound|END_ENTITY	Insulin Signaling in the Control of Glucose and Lipid Homeostasis .
26770991	0	Glucose	111,118	Insulin	14,21	Glucose	Insulin	MESH:D005947	3630	Chemical	Gene	Tolerance|compound|START_ENTITY Hyperinsulinemia|nmod|Tolerance Tolerance|appos|Hyperinsulinemia Resistance|nmod|Tolerance Resistance|nsubj|Assessment Assessment|nmod|END_ENTITY	Assessment of Insulin Resistance in Subjects with Normal Glucose Tolerance , Hyperinsulinemia with Normal Blood Glucose Tolerance , Impaired_Glucose_Tolerance , and Newly Diagnosed Type 2 Diabetes -LRB- Prediabetes Insulin Resistance Research -RRB- .
26770991	0	Glucose	111,118	Insulin	207,214	Glucose	Insulin	MESH:D005947	3630	Chemical	Gene	Tolerance|compound|START_ENTITY Tolerance|appos|Research Research|compound|END_ENTITY	Assessment of Insulin Resistance in Subjects with Normal Glucose Tolerance , Hyperinsulinemia with Normal Blood Glucose Tolerance , Impaired_Glucose_Tolerance , and Newly Diagnosed Type 2 Diabetes -LRB- Prediabetes Insulin Resistance Research -RRB- .
26770991	0	Glucose	57,64	Insulin	14,21	Glucose	Insulin	MESH:D005947	3630	Chemical	Gene	Tolerance|compound|START_ENTITY Resistance|nmod|Tolerance Resistance|nsubj|Assessment Assessment|nmod|END_ENTITY	Assessment of Insulin Resistance in Subjects with Normal Glucose Tolerance , Hyperinsulinemia with Normal Blood Glucose Tolerance , Impaired_Glucose_Tolerance , and Newly Diagnosed Type 2 Diabetes -LRB- Prediabetes Insulin Resistance Research -RRB- .
26770991	0	Glucose	57,64	Insulin	207,214	Glucose	Insulin	MESH:D005947	3630	Chemical	Gene	Tolerance|compound|START_ENTITY Tolerance|appos|Hyperinsulinemia Hyperinsulinemia|nmod|Tolerance Tolerance|appos|Research Research|compound|END_ENTITY	Assessment of Insulin Resistance in Subjects with Normal Glucose Tolerance , Hyperinsulinemia with Normal Blood Glucose Tolerance , Impaired_Glucose_Tolerance , and Newly Diagnosed Type 2 Diabetes -LRB- Prediabetes Insulin Resistance Research -RRB- .
26788515	0	Glucose	77,84	Insulin	0,7	Glucose	Insulin	MESH:D005947	3630	Chemical	Gene	Defect|nmod|START_ENTITY Defect|compound|END_ENTITY	Insulin Secretory Defect and Insulin Resistance in Isolated Impaired Fasting Glucose and Isolated Impaired_Glucose_Tolerance .
26886065	0	Glucose	120,127	Insulin	20,27	Glucose	Insulin	MESH:D005947	3630	Chemical	Gene	Tolerance|compound|START_ENTITY Individuals|nmod|Tolerance Test|nmod|Individuals Test|nsubj|Effect Effect|nmod|Patterns Patterns|compound|END_ENTITY	Effect of Different Insulin Response Patterns During Oral Glucose Tolerance Test on Glycemia in Individuals with Normal Glucose Tolerance .
26886065	0	Glucose	58,65	Insulin	20,27	Glucose	Insulin	MESH:D005947	3630	Chemical	Gene	Tolerance|compound|START_ENTITY Test|nmod|Tolerance Test|nsubj|Effect Effect|nmod|Patterns Patterns|compound|END_ENTITY	Effect of Different Insulin Response Patterns During Oral Glucose Tolerance Test on Glycemia in Individuals with Normal Glucose Tolerance .
26907513	0	Glucose	90,97	Insulin	50,57	Glucose	Insulin	MESH:D005947	3630	Chemical	Gene	Management|compound|START_ENTITY Prevention|nmod|Management Prevention|nmod|System System|compound|END_ENTITY	Hypoglycemia Prevention and User Acceptance of an Insulin Pump System with Predictive Low Glucose Management .
26942445	0	Glucose	55,62	Insulin	22,29	Glucose	Insulin	MESH:D005947	3630	Chemical	Gene	Response|nmod|START_ENTITY Response|compound|END_ENTITY	Mechanisms Regulating Insulin Response to Intragastric Glucose in Lean and Non-Diabetic Obese Subjects : A Randomized , Double-Blind , Parallel-Group Trial .
26982011	0	Glucose	78,85	Insulin	20,27	Glucose	Insulin	MESH:D005947	3630	Chemical	Gene	Syndrome|nmod|START_ENTITY Syndrome|compound|END_ENTITY	Novel Management of Insulin Autoimmune Syndrome with Rituximab and Continuous Glucose Monitoring .
27069678	0	Glucose	57,64	Insulin	66,73	Glucose	Insulin	MESH:D005947	3630	Chemical	Gene	VEGF-A|compound|START_ENTITY VEGF-A|appos|END_ENTITY	Unhealthy Phenotype as Indicated by Salivary Biomarkers : Glucose , Insulin , VEGF-A , and IL-12p70 in Obese Kuwaiti Adolescents .
27081191	0	Glucose	55,62	Insulin	165,172	Glucose	Insulin	MESH:D005947	3630	Chemical	Gene	START_ENTITY|xcomp|Monitoring Monitoring|dep|Injections Injections|compound|END_ENTITY	Design and Methods of a Randomized Trial of Continuous Glucose Monitoring in Persons With Type_1_Diabetes With Impaired Glycemic Control Treated With Multiple Daily Insulin Injections -LRB- GOLD Study -RRB- .
26190026	0	Glucose	42,49	Insulin_Receptor	97,113	Glucose	Insulin Receptor	MESH:D005947	16337(Tax:10090)	Chemical	Gene	Homeostasis|compound|START_ENTITY Exposure|nmod|Homeostasis Exposure|nmod|Pathway Pathway|compound|END_ENTITY	Chronic Exposure to Aroclor_1254 Disrupts Glucose Homeostasis in Male Mice via Inhibition of the Insulin_Receptor Signal Pathway .
25826445	0	Glucose	35,42	Irisin	0,6	Glucose	Irisin	MESH:D005947	252995	Chemical	Gene	Uptake|compound|START_ENTITY Regulates|dobj|Uptake Regulates|nsubj|END_ENTITY	Irisin , a Novel Myokine , Regulates Glucose Uptake in Skeletal Muscle Cells via AMPK .
12829655	0	Glucose	0,7	LOX-1	29,34	Glucose	LOX-1	MESH:D005947	4973	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	Glucose enhances endothelial LOX-1 expression : role for LOX-1 in glucose-induced human monocyte adhesion to endothelium .
12829655	0	Glucose	0,7	LOX-1	56,61	Glucose	LOX-1	MESH:D005947	4973	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|dep|role role|nmod|END_ENTITY	Glucose enhances endothelial LOX-1 expression : role for LOX-1 in glucose-induced human monocyte adhesion to endothelium .
15001526	0	Glucose	0,7	LOX-1	34,39	Glucose	LOX-1	MESH:D005947	4973	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	Glucose enhances human macrophage LOX-1 expression : role for LOX-1 in glucose-induced macrophage foam cell formation .
15001526	0	Glucose	0,7	LOX-1	61,66	Glucose	LOX-1	MESH:D005947	4973	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|dep|role role|nmod|END_ENTITY	Glucose enhances human macrophage LOX-1 expression : role for LOX-1 in glucose-induced macrophage foam cell formation .
25855193	0	Glucose	24,31	LRP1	9,13	Glucose	LRP1	MESH:D005947	16971(Tax:10090)	Chemical	Gene	Metabolism|compound|START_ENTITY Metabolism|compound|END_ENTITY	Neuronal LRP1 Regulates Glucose Metabolism and Insulin Signaling in the Brain .
12136196	0	Glucose	0,7	Leptin	29,35	Glucose	Leptin	MESH:D005947	3952	Chemical	Gene	Regulate|nsubj|START_ENTITY Regulate|dobj|Expression Expression|compound|END_ENTITY	Glucose and Insulin Regulate Leptin Expression in 3T3-F442A Adipocytes .
26315697	0	Glucose	37,44	Leptin	20,26	Glucose	Leptin	MESH:D005947	3952	Chemical	Gene	Absorption|compound|START_ENTITY Appearance|nmod|Absorption Appearance|nmod|Effect Effect|compound|END_ENTITY	The Appearance of a Leptin Effect on Glucose Absorption in Caco2 Cells Depends on Their Differentiation Level .
26445459	0	Glucose	23,30	Leptin	0,6	Glucose	Leptin	MESH:D005947	16846(Tax:10090)	Chemical	Gene	Homeostasis|compound|START_ENTITY Required|nmod|Homeostasis Required|nsubjpass|END_ENTITY	Leptin Is Required for Glucose Homeostasis after Roux-en-Y Gastric Bypass in Mice .
26816939	0	Glucose	17,24	Leptin	83,89	Glucose	Leptin	MESH:D005947	25608(Tax:10116)	Chemical	Gene	Homeostasis|compound|START_ENTITY Homeostasis|nmod|Administration Administration|nmod|END_ENTITY	Dysregulation of Glucose Homeostasis Following Chronic Exogenous Administration of Leptin in Healthy Sprague-Dawley_Rats .
25784555	0	Glucose	49,56	Lipoprotein_Lipase	21,39	Glucose	Lipoprotein Lipase	MESH:D005947	16956(Tax:10090)	Chemical	Gene	Metabolism|compound|START_ENTITY Metabolism|compound|END_ENTITY	Increasing Adipocyte Lipoprotein_Lipase Improves Glucose Metabolism in High Fat Diet-induced Obesity .
17142462	0	Glucose	0,7	MafA	16,20	Glucose	MafA	MESH:D005947	389692	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Glucose induces MafA expression in pancreatic beta cell lines via the hexosamine biosynthetic pathway .
18458340	0	Glucose	0,7	Mlx	26,29	Glucose	Mlx	MESH:D005947	6945	Chemical	Gene	sensing|compound|START_ENTITY sensing|dep|END_ENTITY	Glucose sensing by MondoA : Mlx complexes : a role for hexokinases and direct regulation of thioredoxin-interacting_protein expression .
20068143	14	Glucose	1689,1696	NAMPT	1732,1737	Glucose	SIRT1	MESH:D005947	23411	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|END_ENTITY	Glucose - and palmitate-mediated effects on NAMPT and SIRT1 were prevented by resveratrol in vitro .
5639608	0	Glucose	0,7	NGF	72,75	Glucose	NGF	MESH:D005947	4803	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|dep|effect effect|nmod|-RSB- -RSB-|compound|END_ENTITY	Glucose metabolism in embryonic ganglia : effect of nerve_growth_factor -LSB- NGF -RSB- and insulin .
25660144	0	Glucose	42,49	NPC1L1	8,14	Glucose	NPC1L1	MESH:D005947	237636(Tax:10090)	Chemical	Gene	Metabolism|compound|START_ENTITY Metabolism|compound|END_ENTITY	Hepatic NPC1L1 Overexpression Ameliorates Glucose Metabolism in Diabetic Mice Via Suppression of Gluconeogenesis .
25404734	0	Glucose	43,50	Nephrin	66,73	Glucose	Nephrin	MESH:D005947	4868	Chemical	Gene	Phosphorylation|compound|START_ENTITY Phosphorylation|compound|END_ENTITY	Increased SHP-1 Protein Expression by High Glucose Levels Reduces Nephrin Phosphorylation in Podocytes .
18174169	0	Glucose	0,7	O-GlcNAc	31,39	Glucose	O-GlcNAc	MESH:D005947	8473	Chemical	Gene	stimulates|amod|START_ENTITY END_ENTITY|nsubj|stimulates	Glucose deprivation stimulates O-GlcNAc modification of proteins through up-regulation of O-linked_N-acetylglucosaminyltransferase .
24995978	0	Glucose	0,7	O-GlcNAc_transferase	68,88	Glucose	O-GlcNAc transferase	MESH:D005947	8473	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Glucose regulates mitochondrial motility via Milton modification by O-GlcNAc_transferase .
25873961	0	Glucose	15,22	Osteocalcin	64,75	Glucose	Osteocalcin	MESH:D005947	632	Chemical	Gene	Metabolism|compound|START_ENTITY Bone|dobj|Metabolism Bone|nmod|END_ENTITY	Bone Regulates Glucose Metabolism as an Endocrine Organ through Osteocalcin .
25873961	0	Glucose	15,22	Osteocalcin	64,75	Glucose	Osteocalcin	MESH:D005947	632	Chemical	Gene	Metabolism|compound|START_ENTITY Bone|dobj|Metabolism Bone|nmod|END_ENTITY	Bone Regulates Glucose Metabolism as an Endocrine Organ through Osteocalcin .
26109922	0	Glucose	34,41	Osteocalcin	0,11	Glucose	Osteocalcin	MESH:D005947	12097(Tax:10090)	Chemical	Gene	Metabolism|compound|START_ENTITY END_ENTITY|nmod|Metabolism	Osteocalcin and the Regulation of Glucose Metabolism .
11522022	0	Glucose	0,7	P-selectin	82,92	Glucose	P-selectin	MESH:D005947	6403	Chemical	Gene	modulate|nsubj|START_ENTITY modulate|xcomp|express express|dobj|END_ENTITY	Glucose and insulin modulate the capacity of endothelial cells -LRB- HUVEC -RRB- to express P-selectin and bind a monocytic cell line -LRB- U937 -RRB- .
26219917	0	Glucose	0,7	P38	54,57	Glucose	P38	MESH:D005947	1432	Chemical	Gene	increases|amod|START_ENTITY tau|nsubj|increases tau|dobj|phosphorylation phosphorylation|nmod|kinase kinase|compound|END_ENTITY	Glucose deprivation increases tau phosphorylation via P38 mitogen-activated protein kinase .
25621554	0	Glucose	28,35	PI3_Kinase	113,123	Glucose	PI3 Kinase	MESH:D005947	18708(Tax:10090)	Chemical	Gene	Proliferation|compound|START_ENTITY Concentrations|nmod|Proliferation Via|nsubj|Concentrations Via|dobj|Pathway Pathway|compound|END_ENTITY	Different Concentrations of Glucose Regulate Proliferation and Osteogenic Differentiation of Osteoblasts Via the PI3_Kinase / Akt Pathway .
22654830	0	Glucose	32,39	PPARy	64,69	Glucose	PPARy	MESH:D005947	5468	Chemical	Gene	Control|nmod|START_ENTITY Control|nmod|END_ENTITY	Control of Brown Adipose Tissue Glucose and Lipid Metabolism by PPARy .
27100993	0	Glucose	82,89	PPARy	121,126	Glucose	PPARy	MESH:D005947	5468	Chemical	Gene	Uptake|compound|START_ENTITY triquetrum|appos|Uptake Phenylpropanoid_Glucosides|nmod|triquetrum Phenylpropanoid_Glucosides|nmod|END_ENTITY	Tadehaginosides_A-J , Phenylpropanoid_Glucosides from Tadehagi triquetrum , Enhance Glucose Uptake via the Upregulation of PPARy and GLUT-4 in C2C12 Myotubes .
26440364	0	Glucose	24,31	PPP2R5C	0,7	Glucose	PPP2R5C	MESH:D005947	5527	Chemical	Gene	Couples|dobj|START_ENTITY Couples|nsubj|END_ENTITY	PPP2R5C Couples Hepatic Glucose and Lipid Homeostasis .
24953606	0	Glucose	0,7	Pax6	18,22	Glucose	Pax6	MESH:D005947	25509(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	Glucose modulates Pax6 expression through the JNK/p38 MAP kinase pathway in pancreatic beta-cells .
12213820	0	Glucose	0,7	Per1	23,27	Glucose	Per1	MESH:D005947	287422(Tax:10116)	Chemical	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|END_ENTITY	Glucose down-regulates Per1 and Per2 mRNA levels and induces circadian gene expression in cultured Rat-1 fibroblasts .
26784927	0	Glucose	0,7	Per2	15,19	Glucose	Per2	MESH:D005947	8864	Chemical	Gene	Independent|compound|START_ENTITY Independent|compound|END_ENTITY	Glucose Alters Per2 Rhythmicity Independent of AMPK , Whereas AMPK Inhibitor Compound_C Causes Profound Repression of Clock Genes and AgRP in mHypoE-37 Hypothalamic Neurons .
23690860	0	Glucose	27,34	Peroxisome_Proliferator-Activated_Receptor_Gamma	56,104	Glucose	Peroxisome Proliferator-Activated Receptor Gamma	MESH:D005947	19016(Tax:10090)	Chemical	Gene	Uptake|nsubj|START_ENTITY Uptake|nmod|END_ENTITY	Boehmeria nivea Stimulates Glucose Uptake by Activating Peroxisome_Proliferator-Activated_Receptor_Gamma in C2C12 Cells and Improves Glucose Intolerance in Mice Fed a High-Fat Diet .
26023239	0	Glucose	152,159	Phosphatidylinositol_3-Kinase	22,51	Glucose	Phosphatidylinositol 3-Kinase	MESH:D005947	5293	Chemical	Gene	Transporter|compound|START_ENTITY mediated|nmod|Transporter Glycolysis|acl|mediated Responsible|nmod|Glycolysis mTOR|acl:relcl|Responsible mTOR|dep|Signaling Signaling|nmod|END_ENTITY	Signaling through the Phosphatidylinositol_3-Kinase -LRB- PI3K -RRB- / Mammalian_Target_of_Rapamycin -LRB- mTOR -RRB- Axis is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- - mutated Lung_Adenocarcinoma .
26023239	0	Glucose	152,159	Phosphatidylinositol_3-Kinase	22,51	Glucose	Phosphatidylinositol 3-Kinase	MESH:D005947	5293	Chemical	Gene	Transporter|compound|START_ENTITY mediated|nmod|Transporter Glycolysis|acl|mediated Responsible|nmod|Glycolysis mTOR|acl:relcl|Responsible mTOR|dep|Signaling Signaling|nmod|END_ENTITY	Signaling through the Phosphatidylinositol_3-Kinase -LRB- PI3K -RRB- / Mammalian_Target_of_Rapamycin -LRB- mTOR -RRB- Axis is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- - mutated Lung_Adenocarcinoma .
26383638	0	Glucose	68,75	Phosphoenolpyruvate_Carboxykinase	0,33	Glucose	Phosphoenolpyruvate Carboxykinase	MESH:D005947	5106	Chemical	Gene	Enzyme|dep|START_ENTITY END_ENTITY|appos|Enzyme	Phosphoenolpyruvate_Carboxykinase , a Key Enzyme That Controls Blood Glucose , Is a Target of Retinoic_Acid Receptor-Related Orphan Receptor a. UNASSIGNED : Phosphoenolpyruvate_carboxykinase -LRB- PEPCK -RRB- catalyzes a committed and rate-limiting step in hepatic gluconeogenesis , and its activity is tightly regulated to maintain blood glucose levels within normal limits .
26420624	0	Glucose	49,56	Proinsulin	16,26	Glucose	Proinsulin	MESH:D005947	3630	Chemical	Gene	Progressive|compound|START_ENTITY Levels|dep|Progressive Levels|compound|END_ENTITY	Elevated Intact Proinsulin Levels During an Oral Glucose Challenge Indicate Progressive - Cell Dysfunction and May Be Predictive for Development of Type 2 Diabetes .
26808535	0	Glucose	0,7	Protein_Tyrosine_Phosphatase_1B	148,179	Glucose	Protein Tyrosine Phosphatase 1B	MESH:D005947	19246(Tax:10090)	Chemical	Gene	Activities|compound|START_ENTITY _|nsubj|Activities _|dobj|Ether Ether|appos|Product Product|nmod|Odonthaliacorymbifera Odonthaliacorymbifera|nmod|Inhibition Inhibition|compound|END_ENTITY	Glucose Uptake Activities of Bis _ -LRB- 2 , _ 3-Dibromo-4 , _ 5-Dihydroxybenzyl -RRB- _ Ether , a Novel Marine Natural Product from Red Alga Odonthaliacorymbifera with Protein_Tyrosine_Phosphatase_1B Inhibition , In Vitro and In Vivo .
21432623	0	Glucose	0,7	RMI1	18,22	Glucose	RMI1	MESH:D005947	80010	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Glucose regulates RMI1 expression through the E2F pathways in adipose cells .
12042442	0	Glucose	0,7	SGLT-1	19,25	Glucose	SGLT-1	MESH:D005947	492300(Tax:9940)	Chemical	Gene	uptake|amod|START_ENTITY uptake|nmod|END_ENTITY	Glucose uptake via SGLT-1 is stimulated by beta -LRB- 2 -RRB- - adrenoceptors in the ruminal epithelium of sheep .
20980548	0	Glucose	0,7	SGLT1	62,67	Glucose	SGLT1	MESH:D005947	6523	Chemical	Gene	transport|amod|START_ENTITY transport|parataxis|cotransporters cotransporters|dobj|END_ENTITY	Glucose transport by human renal Na + / D-glucose cotransporters SGLT1 and SGLT2 .
25898949	0	Glucose	0,7	SGLT1	94,99	Glucose	SGLT1	MESH:D005947	25552(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|mechanisms mechanisms|nmod|END_ENTITY	Glucose stimulates neurotensin secretion from the rat small intestine by mechanisms involving SGLT1 and GLUT2 leading to cell depolarization and calcium influx .
26121582	0	Glucose	62,69	SGLT1	14,19	Glucose	SGLT1	MESH:D005947	6523	Chemical	Gene	Uptake|compound|START_ENTITY Expression|nmod|Uptake Expression|nmod|END_ENTITY	Expression of SGLT1 in Human Hearts and Impairment of Cardiac Glucose Uptake by Phlorizin during Ischemia-Reperfusion_Injury in Mice .
25563886	0	Glucose	0,7	SLC2A1	23,29	Glucose	SLC2A1	MESH:D005947	6513	Chemical	Gene	START_ENTITY|dobj|Transporter Transporter|appos|END_ENTITY	Glucose Transporter 1 -LRB- SLC2A1 -RRB- and Vascular_Endothelial_Growth_Factor_A -LRB- VEGFA -RRB- Predict Survival After Resection of Colorectal_Cancer_Liver_Metastasis .
24200979	0	Glucose	0,7	T1R3	91,95	Glucose	T1R3	MESH:D005947	83756	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|advcl|acting acting|nmod|END_ENTITY	Glucose promotes its own metabolism by acting on the cell-surface glucose-sensing receptor T1R3 .
25947913	0	Glucose	69,76	T1R3	25,29	Glucose	T1R3	MESH:D005947	83756	Chemical	Gene	Activated|nmod|START_ENTITY END_ENTITY|dep|Activated	Glucose-Sensing Receptor T1R3 : A New Signaling Receptor Activated by Glucose in Pancreatic b-Cells .
25969708	0	Glucose	29,36	T1R3	76,80	Glucose	T1R3	MESH:D005947	83771(Tax:10090)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Return of the glucoreceptor : Glucose activates the glucose-sensing receptor T1R3 and facilitates metabolism in pancreatic b-cells .
25983343	0	Glucose	63,70	T1R3	23,27	Glucose	T1R3	MESH:D005947	83771(Tax:10090)	Chemical	Gene	Metabolism|compound|START_ENTITY Involvement|nmod|Metabolism Involvement|nmod|Protein Protein|compound|END_ENTITY	The Involvement of the T1R3 Receptor Protein in the Control of Glucose Metabolism in Mice at Different Levels of Glycemia .
25983343	0	Glucose	63,70	T1R3	23,27	Glucose	T1R3	MESH:D005947	83771(Tax:10090)	Chemical	Gene	Metabolism|compound|START_ENTITY Involvement|nmod|Metabolism Involvement|nmod|Protein Protein|compound|END_ENTITY	The Involvement of the T1R3 Receptor Protein in the Control of Glucose Metabolism in Mice at Different Levels of Glycemia .
21383163	0	Glucose	0,7	T1r3	103,107	Glucose	T1r3	MESH:D005947	83771(Tax:10090)	Chemical	Gene	transporters|amod|START_ENTITY taste|nsubj|transporters taste|dep|expressing expressing|nsubj|receptor receptor|appos|END_ENTITY	Glucose transporters and ATP-gated K + -LRB- KATP -RRB- metabolic sensors are present in type 1 taste receptor 3 -LRB- T1r3 -RRB- - expressing taste cells .
24879834	0	Glucose	54,61	TBC1D1	89,95	Glucose	TBC1D1	MESH:D005947	23216	Chemical	Gene	Uptake|nsubj|START_ENTITY Uptake|advcl|Interacting Interacting|nmod|END_ENTITY	The Adaptor Protein APPL2 Inhibits Insulin-Stimulated Glucose Uptake by Interacting With TBC1D1 in Skeletal Muscle .
27049325	0	Glucose	87,94	TCF7L2	65,71	Glucose	TCF7L2	MESH:D005947	6934	Chemical	Gene	Levels|compound|START_ENTITY Levels|compound|END_ENTITY	Risk Alleles in/near ADCY5 , ADRA2A , CDKAL1 , CDKN2A/B , GRB10 , and TCF7L2 Elevate Plasma Glucose Levels at Birth and in Early Childhood : Results from the FAMILY Study .
27010330	0	Glucose	54,61	TGF-b1	105,111	Glucose	TGF-b1	MESH:D005947	59086(Tax:10116)	Chemical	Gene	Induced|nmod|START_ENTITY Induced|nmod|END_ENTITY	Oxymatrine Inhibits Renal Tubular EMT Induced by High Glucose via Upregulation of SnoN and Inhibition of TGF-b1 / Smad Signaling Pathway .
24731445	0	Glucose	0,7	TRPC6	31,36	Glucose	TRPC6	MESH:D005947	89823(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nummod|END_ENTITY	Glucose specifically regulates TRPC6 expression in the podocyte in an AngII-dependent manner .
26405273	0	Glucose	20,27	Toll	11,15	Glucose	Toll	MESH:D005947	7099	Chemical	Gene	Regulation|compound|START_ENTITY END_ENTITY|nmod|Regulation	Paying the Toll for Glucose Regulation : A Central Role for TLR3 .
25896065	0	Glucose	60,67	Toll-Like_Receptor_4	0,20	Glucose	Toll-Like Receptor 4	MESH:D005947	7099	Chemical	Gene	Transduction|compound|START_ENTITY Complex|nmod|Transduction END_ENTITY|parataxis|Complex	Toll-Like_Receptor_4 / Spleen Tyrosine_Kinase Complex in High Glucose Signal Transduction of Proximal Tubular Epithelial Cells .
15814533	0	Glucose	0,7	VEGF	109,113	Glucose	VEGF	MESH:D005947	7422	Chemical	Gene	products|amod|START_ENTITY downregulate|nsubj|products downregulate|nmod|cells cells|dep|role role|nmod|END_ENTITY	Glucose degradation products downregulate ZO-1 expression in human peritoneal mesothelial cells : the role of VEGF .
7490534	0	Glucose	0,7	acetyl-CoA_carboxylase	22,44	Glucose	acetyl-CoA carboxylase	MESH:D005947	31	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Glucose activation of acetyl-CoA_carboxylase in association with insulin secretion in a pancreatic beta-cell line .
2925258	0	Glucose	0,7	apolipoprotein_A_and_B	37,59	Glucose	apolipoprotein A and B	MESH:D005947	338	Chemical	Gene	metabolism|amod|START_ENTITY END_ENTITY|nsubj|metabolism	Glucose metabolism , lipidic pattern , apolipoprotein_A_and_B during hemodialysis with cuprophan and hemodialysis-hemoperfusion .
11729249	0	Glucose	0,7	basic_fibroblast_growth_factor	31,61	Glucose	basic fibroblast growth factor	MESH:D005947	2247	Chemical	Gene	alter|nsubj|START_ENTITY alter|dobj|expression expression|compound|END_ENTITY	Glucose and prednisolone alter basic_fibroblast_growth_factor expression in peritoneal mesothelial cells and fibroblasts .
1845801	0	Glucose	0,7	bradykinin	33,43	Glucose	bradykinin	MESH:D005947	3827	Chemical	Gene	stimulation|amod|START_ENTITY stimulation|nmod|END_ENTITY	Glucose transport stimulation by bradykinin in Swiss 3T3 fibroblasts : a pertussis toxin-sensitive mechanism operates without involvement of arachidonic_acid and cyclic_AMP .
9092950	0	Glucose	0,7	c-myc	107,112	Glucose	c-myc	MESH:D005947	4609	Chemical	Gene	cytotoxicity|amod|START_ENTITY cytotoxicity|dep|cells cells|dep|role role|acl|END_ENTITY	Glucose deprivation-induced cytotoxicity in drug resistant human breast_carcinoma MCF-7 / ADR cells : role of c-myc and bcl-2 in apoptotic cell death .
7203846	0	Glucose	0,7	catalase	49,57	Glucose	catalase	MESH:D005947	24248(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inactivation inactivation|amod|END_ENTITY	Glucose and dietary vitamin_E protection against catalase inactivation in the red cells of rats .
19965590	0	Glucose	0,7	cholesterol_7alpha-hydroxylase	19,49	Glucose	cholesterol 7alpha-hydroxylase	MESH:D005947	1581	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|transcription transcription|amod|END_ENTITY	Glucose stimulates cholesterol_7alpha-hydroxylase gene transcription in human hepatocytes .
21521747	0	Glucose	0,7	cyclin_D2	18,27	Glucose	cyclin D2	MESH:D005947	894	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Glucose regulates cyclin_D2 expression in quiescent and replicating pancreatic b-cells through glycolysis and calcium channels .
18671716	0	Glucose	0,7	dipeptidyl_peptidase_IV	22,45	Glucose	dipeptidyl peptidase IV	MESH:D005947	1803	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Glucose regulation of dipeptidyl_peptidase_IV gene expression is mediated by hepatocyte nuclear factor-1alpha in epithelial intestinal cells .
8567668	0	Glucose	0,7	eIF-2B	74,80	Glucose	eIF-2B	MESH:D005947	117019(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|xcomp|END_ENTITY	Glucose stimulates the activity of the guanine_nucleotide-exchange factor eIF-2B in isolated rat islets of Langerhans .
1628711	0	Glucose	0,7	erythropoietin	54,68	Glucose	erythropoietin	MESH:D005947	24335(Tax:10116)	Chemical	Gene	uptake|amod|START_ENTITY uptake|dep|effects effects|nmod|END_ENTITY	Glucose uptake by rat erythroid cells : the effects of erythropoietin and dexamethasone .
11007796	0	Glucose	0,7	extracellular_signal-regulated_kinase	52,89	Glucose	extracellular signal-regulated kinase	MESH:D005947	5594	Chemical	Gene	activates|nsubj|START_ENTITY activates|dep|END_ENTITY	Glucose activates mitogen-activated protein kinase -LRB- extracellular_signal-regulated_kinase -RRB- through proline-rich_tyrosine_kinase-2 and the Glut1 glucose transporter .
15047603	0	Glucose	0,7	farnesoid_X_receptor	40,60	Glucose	farnesoid X receptor	MESH:D005947	60351(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Glucose regulates the expression of the farnesoid_X_receptor in liver .
24037988	0	Glucose	0,7	farnesoid_X_receptor	81,101	Glucose	farnesoid X receptor	MESH:D005947	9971	Chemical	Gene	O-GlcNAcylation|compound|START_ENTITY regulates|nsubj|O-GlcNAcylation regulates|dobj|END_ENTITY	Glucose sensing O-GlcNAcylation pathway regulates the nuclear bile_acid receptor farnesoid_X_receptor -LRB- FXR -RRB- .
17327226	0	Glucose	0,7	fibroblast_growth_factor-2	36,62	Glucose	fibroblast growth factor-2	MESH:D005947	2247	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Glucose modulates basement membrane fibroblast_growth_factor-2 via alterations in endothelial cell permeability .
9361993	0	Glucose	0,7	gastrin	89,96	Glucose	gastrin	MESH:D005947	25320(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|advcl|affecting affecting|dobj|levels levels|compound|END_ENTITY	Glucose suppresses the activity of rat oxyntic histidine_decarboxylase without affecting gastrin levels .
21097901	0	Glucose	0,7	ghrelin	51,58	Glucose	ghrelin	MESH:D005947	100861189	Chemical	Gene	control|nsubj|START_ENTITY control|nmod|mice mice|nmod|inhibitor inhibitor|compound|END_ENTITY	Glucose and weight control in mice with a designed ghrelin O-acyltransferase inhibitor .
16888215	0	Glucose	0,7	glucagon_receptor	26,43	Glucose	glucagon receptor	MESH:D005947	24953(Tax:10116)	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|gene gene|compound|END_ENTITY	Glucose activation of the glucagon_receptor gene : functional dissimilarity with several other glucose response elements .
18370405	0	Glucose	0,7	glucokinase	22,33	Glucose	glucokinase	MESH:D005947	2645	Chemical	Gene	modulation|amod|START_ENTITY modulation|nmod|END_ENTITY	Glucose modulation of glucokinase activation by small molecules .
2211598	0	Glucose	0,7	glucokinase	18,29	Glucose	glucokinase	MESH:D005947	24385(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	Glucose regulates glucokinase activity in cultured islets from rat pancreas .
7958490	0	Glucose	0,7	glucokinase	90,101	Glucose	glucokinase	MESH:D005947	2645	Chemical	Gene	potentiation|amod|START_ENTITY impaired|nsubjpass|potentiation impaired|nmod|subjects subjects|nmod|mutation mutation|amod|END_ENTITY	Glucose potentiation of arginine-induced insulin secretion is impaired in subjects with a glucokinase Glu256Lys mutation .
8446591	0	Glucose	0,7	glucokinase	64,75	Glucose	glucokinase	MESH:D005947	2645	Chemical	Gene	sensing|compound|START_ENTITY sensing|dep|role role|nmod|END_ENTITY	Glucose sensing in pancreatic islet beta cells : the key role of glucokinase and the glycolytic intermediates .
8690154	0	Glucose	0,7	glucokinase	44,55	Glucose	glucokinase	MESH:D005947	24385(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|velocities velocities|nmod|utilization utilization|compound|END_ENTITY	Glucose regulates the maximal velocities of glucokinase and glucose utilization in the immature fetal rat pancreatic islet .
9662046	0	Glucose	0,7	glucokinase	89,100	Glucose	glucokinase	MESH:D005947	103988(Tax:10090)	Chemical	Gene	modulation|amod|START_ENTITY END_ENTITY|nsubj|modulation	Glucose modulation of ATP-sensitive K-currents in wild-type , homozygous and heterozygous glucokinase knock-out mice .
20228249	0	Glucose	0,7	glucose-6-phosphate_dehydrogenase	102,135	Glucose	glucose-6-phosphate dehydrogenase	MESH:D005947	2539	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|sources sources|dep|role role|nmod|END_ENTITY	Glucose regulates enzymatic sources of mitochondrial NADPH in skeletal muscle cells ; a novel role for glucose-6-phosphate_dehydrogenase .
3776114	0	Glucose	1,8	glucose-6-phosphate_dehydrogenase	37,70	Glucose	glucose-6-phosphate dehydrogenase	MESH:D005947	24377(Tax:10116)	Chemical	Gene	utilization|compound|START_ENTITY utilization|nmod|dehydrogenase dehydrogenase|amod|END_ENTITY	-LSB- Glucose utilization and activity of glucose-6-phosphate_dehydrogenase , isocitrate dehydrogenase and malate dehydrogenase in rat erythrocytes after treatment with tuberculostatic agents -RSB- .
7496544	0	Glucose	0,7	glucose-6-phosphate_dehydrogenase	87,120	Glucose	glucose-6-phosphate dehydrogenase	MESH:D005947	2539	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|dep|engineering engineering|nmod|construction construction|nmod|mutant mutant|amod|END_ENTITY	Glucose metabolism in ` Sphingomonas elodea ' : pathway engineering via construction of a glucose-6-phosphate_dehydrogenase insertion mutant .
11309343	0	Glucose	0,7	glut-1	20,26	Glucose	glut-1	MESH:D005947	6513	Chemical	Gene	transporter|nsubj|START_ENTITY transporter|dobj|correlates correlates|amod|END_ENTITY	Glucose transporter glut-1 expression correlates with tumor hypoxia and predicts metastasis-free survival in advanced carcinoma_of_the_cervix .
8504736	0	Glucose	0,7	glut_1	18,24	Glucose	glut 1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|function function|amod|END_ENTITY	Glucose regulates glut_1 function and expression in fetal rat lung and muscle in vitro .
11735099	0	Glucose	0,7	glycosylphosphatidylinositol-specific_phospholipase_D	29,82	Glucose	glycosylphosphatidylinositol-specific phospholipase D	MESH:D005947	14756(Tax:10090)	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|amod|END_ENTITY	Glucose and insulin regulate glycosylphosphatidylinositol-specific_phospholipase_D expression in islet beta cells .
10603743	0	Glucose	1,8	growth_hormone	90,104	Glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	metabolism|compound|START_ENTITY treated|nsubj|metabolism treated|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Glucose metabolism and insulin sensitivity in patients with Turner_syndrome treated with growth_hormone -RSB- .
10626560	0	Glucose	0,7	growth_hormone	75,89	Glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	homeostasis|nsubj|START_ENTITY homeostasis|nmod|implications implications|nmod|therapy therapy|amod|END_ENTITY	Glucose homeostasis in Prader-Willi_syndrome and potential implications of growth_hormone therapy .
14970004	0	Glucose	0,7	growth_hormone	73,87	Glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	homeostasis|amod|START_ENTITY homeostasis|dep|hyperresponsiveness hyperresponsiveness|acl|END_ENTITY	Glucose homeostasis in abdominal_obesity : hepatic hyperresponsiveness to growth_hormone action .
2019924	0	Glucose	0,7	growth_hormone	66,80	Glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	tolerance|amod|START_ENTITY tolerance|nmod|treatment treatment|amod|END_ENTITY	Glucose tolerance in children with renal allografts and effect of growth_hormone treatment .
24360789	0	Glucose	0,7	growth_hormone	79,93	Glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	homeostasis|amod|START_ENTITY homeostasis|nmod|adults adults|nmod|Prader-Willi_syndrome Prader-Willi_syndrome|nmod|treatment treatment|nmod|END_ENTITY	Glucose homeostasis in adults with Prader-Willi_syndrome during treatment with growth_hormone : results from a 12-month prospective study .
5101781	0	Glucose	0,7	growth_hormone	54,68	Glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	homeostasis|nsubj|START_ENTITY homeostasis|nmod|absence absence|nmod|END_ENTITY	Glucose and lipid homeostasis in the absence of human growth_hormone .
579023	1	Glucose	86,93	growth_hormone	113,127	Glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	START_ENTITY|appos|levels levels|compound|END_ENTITY	I. Glucose , insulin and human growth_hormone levels during oral glucose tolerance tests .
7046459	0	Glucose	0,7	growth_hormone	51,65	Glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	transport|advmod|START_ENTITY transport|nmod|END_ENTITY	Glucose transport in adipocytes and its control by growth_hormone in vivo .
7559892	0	Glucose	0,7	growth_hormone	9,23	Glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	aged|advmod|START_ENTITY aged|nsubj|END_ENTITY	Glucose , growth_hormone , cortisol , and insulin responses to glucagon injection in normal infants , aged 0.5-12 months .
7665372	0	Glucose	0,7	growth_hormone	42,56	Glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	modulation|amod|START_ENTITY modulation|nmod|hormone hormone|amod|END_ENTITY	Glucose and free fatty_acid modulation of growth_hormone and luteinizing hormone secretion by cultured porcine pituitary cells .
9691211	0	Glucose	0,7	growth_hormone	82,96	Glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	START_ENTITY|nmod|treatment treatment|compound|END_ENTITY	Glucose tolerance and insulin secretion in children before and during recombinant growth_hormone treatment .
26303164	0	Glucose	5,12	hERG	23,27	Glucose	hERG	MESH:D005947	2078	Chemical	Gene	Represses|nsubj|START_ENTITY Represses|xcomp|END_ENTITY	High Glucose Represses hERG K Channel Expression through Trafficking Inhibition .
26303164	0	Glucose	5,12	hERG	23,27	Glucose	hERG	MESH:D005947	2078	Chemical	Gene	Represses|nsubj|START_ENTITY Represses|xcomp|END_ENTITY	High Glucose Represses hERG K Channel Expression through Trafficking Inhibition .
18758746	0	Glucose	0,7	hepatic_lipase	18,32	Glucose	hepatic lipase	MESH:D005947	24538(Tax:10116)	Chemical	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	Glucose increases hepatic_lipase expression in HepG2 liver cells through upregulation of upstream stimulatory factors 1 and 2 .
15766720	0	Glucose	0,7	hexokinase	81,91	Glucose	hexokinase	MESH:D005947	851167(Tax:4932)	Chemical	Gene	sensing|compound|START_ENTITY based|nsubj|sensing based|nmod|fluorescence fluorescence|nmod|END_ENTITY	Glucose sensing based on the intrinsic fluorescence of sol-gel immobilized yeast hexokinase .
3053666	0	Glucose	0,7	hexokinase	109,119	Glucose	hexokinase	MESH:D005947	851167(Tax:4932)	Chemical	Gene	uptake|amod|START_ENTITY uptake|dep|effect effect|nmod|mutations mutations|nmod|genes genes|amod|END_ENTITY	Glucose uptake in Saccharomyces_cerevisiae grown under anaerobic conditions : effect of null mutations in the hexokinase and glucokinase structural genes .
9361993	0	Glucose	0,7	histidine_decarboxylase	47,70	Glucose	histidine decarboxylase	MESH:D005947	24443(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|activity activity|nmod|END_ENTITY	Glucose suppresses the activity of rat oxyntic histidine_decarboxylase without affecting gastrin levels .
16253768	0	Glucose	0,7	hypoxia-inducible_factor-1alpha	48,79	Glucose	hypoxia-inducible factor-1alpha	MESH:D005947	3091	Chemical	Gene	requirement|amod|START_ENTITY requirement|nmod|END_ENTITY	Glucose requirement for hypoxic accumulation of hypoxia-inducible_factor-1alpha -LRB- HIF-1alpha -RRB- .
10091158	0	Glucose	0,7	insulin	19,26	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|amod|START_ENTITY tolerance|appos|secretion secretion|nmod:npmod|END_ENTITY	Glucose tolerance , insulin secretion and peripheral sensitivity in thalassaemia major .
10102686	0	Glucose	0,7	insulin	45,52	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	entrainment|amod|START_ENTITY entrainment|nmod|END_ENTITY	Glucose entrainment of high-frequency plasma insulin oscillations in control and type 2 diabetic subjects .
10413738	0	Glucose	0,7	insulin	58,65	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	transporters|amod|START_ENTITY transporters|dep|implications implications|nmod|resistance resistance|compound|END_ENTITY	Glucose transporters and insulin action -- implications for insulin resistance and diabetes_mellitus .
10694797	0	Glucose	0,7	insulin	38,45	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Glucose regulated production of human insulin in rat hepatocytes .
10720074	0	Glucose	0,7	insulin	31,38	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|nmod|END_ENTITY	Glucose metabolism rather than insulin is a main determinant of leptin secretion in humans .
10868963	0	Glucose	0,7	insulin	22,29	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	modulation|amod|START_ENTITY modulation|nmod|levels levels|compound|END_ENTITY	Glucose modulation of insulin mRNA levels is dependent on transcription factor PDX-1 and occurs independently of changes in intracellular Ca2 + .
1185889	0	Glucose	0,7	insulin	25,32	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|amod|START_ENTITY tolerance|appos|END_ENTITY	Glucose tolerance , serum insulin and lipid_abnormalities in patients with coronary_heart_disease .
11914108	0	Glucose	0,7	insulin	87,94	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	flux|compound|START_ENTITY normalized|nsubjpass|flux normalized|nmod|resistance resistance|compound|END_ENTITY	Glucose flux is normalized by compensatory hyperinsulinaemia in growth_hormone-induced insulin resistance in healthy subjects , while skeletal muscle protein synthesis remains unchanged .
11959047	0	Glucose	0,7	insulin	8,15	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	infusion|amod|START_ENTITY infusion|compound|END_ENTITY	Glucose insulin potassium infusion improves systolic function in patients with chronic ischemic_cardiomyopathy .
12490950	0	Glucose	0,7	insulin	45,52	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	recycling|amod|START_ENTITY recycling|nmod|response response|nmod|END_ENTITY	Glucose transporter recycling in response to insulin is facilitated by myosin Myo1c .
12574208	0	Glucose	0,7	insulin	29,36	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	stimulates|amod|START_ENTITY pulsatile|nsubj|stimulates pulsatile|dobj|secretion secretion|compound|END_ENTITY	Glucose stimulates pulsatile insulin secretion from human pancreatic islets by increasing secretory burst mass : dose-response relationships .
12760905	0	Glucose	0,7	insulin	94,101	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|modulation modulation|nmod|Cdc42 Cdc42|acl|cycling cycling|xcomp|stimulate stimulate|dobj|secretion secretion|compound|END_ENTITY	Glucose regulates the cortical actin network through modulation of Cdc42 cycling to stimulate insulin secretion .
1423910	18	Glucose	2138,2145	insulin	2184,2191	Glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	rates|amod|START_ENTITY increased|nsubj|rates increased|nmod|infusion infusion|compound|END_ENTITY	Glucose infusion rates -LRB- GIR -RRB- increased during insulin infusion but were not different between groups at any insulin infusion rate .
15166251	0	Glucose	0,7	insulin	22,29	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Glucose regulation of insulin gene expression requires the recruitment of p300 by the beta-cell-specific transcription factor Pdx-1 .
1553183	0	Glucose	0,7	insulin	9,16	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	START_ENTITY|dep|polypeptide polypeptide|compound|END_ENTITY	Glucose , insulin , gastric inhibitory polypeptide , and pancreatic_polypeptide responses to polycose during pregnancy .
1604880	0	Glucose	1,8	insulin	46,53	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY tolerance|dep|changes changes|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Glucose tolerance in the elderly -- changes in insulin , C-peptide and glucagon secretion -RSB- .
1608023	0	Glucose	0,7	insulin	9,16	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	serum|advmod|START_ENTITY serum|nsubj|levels levels|compound|END_ENTITY	Glucose , insulin , HGH and IGF-I levels in maternal_serum , amniotic_fluid and umbilical venous serum : a comparison between late normal pregnancy and pregnancies complicated with diabetes and fetal_growth_retardation .
17239301	0	Glucose	1,8	insulin	107,114	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	START_ENTITY|dep|application application|nmod|index index|compound|END_ENTITY	-LSB- Glucose and insulin concentrations during oral glucose tolerance test in healthy children -- application of insulin resistance index according to Belfiore in the developmental age -RSB- .
17327454	0	Glucose	0,7	insulin	22,29	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|transcription transcription|compound|END_ENTITY	Glucose regulation of insulin gene transcription and pre-mRNA processing in human islets .
17427110	0	Glucose	0,7	insulin	20,27	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|appos|secretion secretion|compound|END_ENTITY	Glucose metabolism , insulin secretion and insulin sensitivity in juvenile_hemochromatosis .
17646121	0	Glucose	0,7	insulin	54,61	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|nsubj|START_ENTITY control|nmod|critical_illness critical_illness|acl|using using|dobj|calculator calculator|compound|END_ENTITY	Glucose control in critical_illness using a web-based insulin dose calculator .
18778246	0	Glucose	0,7	insulin	22,29	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Glucose regulation of insulin gene expression in pancreatic beta-cells .
1892901	0	Glucose	0,7	insulin	76,83	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	START_ENTITY|dep|levels levels|nmod|END_ENTITY	Glucose : a more powerful modulator of fructose_2 ,6 - bisphosphate levels than insulin in human hepatocytes .
19205780	0	Glucose	0,7	insulin	156,163	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	responses|compound|START_ENTITY breakfasts|nsubj|responses breakfasts|dobj|varying varying|dep|study study|nmod|women women|nmod|risk risk|nmod|resistance resistance|compound|END_ENTITY	Glucose and insulin responses to whole grain breakfasts varying in soluble fiber , beta-glucan : a dose response study in obese women with increased risk for insulin resistance .
19819962	0	Glucose	0,7	insulin	29,36	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	generates|nsubj|START_ENTITY generates|dobj|END_ENTITY	Glucose generates coincident insulin and somatostatin pulses and antisynchronous glucagon pulses from human pancreatic islets .
20074859	0	Glucose	0,7	insulin	49,56	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|dep|role role|nmod|hormones hormones|compound|END_ENTITY	Glucose metabolism in burn patients : the role of insulin and other endocrine hormones .
20144488	0	Glucose	0,7	insulin	71,78	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|amod|START_ENTITY based|nsubj|control based|nmod|frequency frequency|nmod|administration administration|compound|END_ENTITY	Glucose control in patients with type 2 diabetes based on frequency of insulin glargine administration .
2019259	0	Glucose	0,7	insulin	29,36	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|sensitivity sensitivity|compound|END_ENTITY	Glucose and insulin regulate insulin sensitivity in primary cultured adipocytes without affecting insulin receptor kinase activity .
2019259	0	Glucose	0,7	insulin	98,105	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|advcl|affecting affecting|dobj|activity activity|compound|END_ENTITY	Glucose and insulin regulate insulin sensitivity in primary cultured adipocytes without affecting insulin receptor kinase activity .
206144	1	Glucose	145,152	insulin	154,161	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	START_ENTITY|appos|growth_hormone growth_hormone|compound|END_ENTITY	Glucose , insulin , growth_hormone , triglycerides , and Premarin .
22181063	0	Glucose	0,7	insulin	145,152	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|amod|START_ENTITY control|dep|study study|acl|controlled controlled|nmod|system system|acl|comparing comparing|dobj|use use|nmod|glargine glargine|compound|END_ENTITY	Glucose control in acute_myocardial_infarction : a pilot randomized study controlled by continuous glucose monitoring system comparing the use of insulin glargine with standard of care .
230061	0	Glucose	0,7	insulin	26,33	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|amod|START_ENTITY tolerance|appos|END_ENTITY	Glucose tolerance , plasma insulin and alpha-lipoproteins in young male myocardial_infarction survivors compared with controls matched on serum cholesterol concentration .
25382150	0	Glucose	0,7	insulin	59,66	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|acl|expressing expressing|nmod|promoter promoter|compound|END_ENTITY	Glucose metabolism in pigs expressing human genes under an insulin promoter .
25500952	0	Glucose	0,7	insulin	78,85	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	uptake|amod|START_ENTITY impaired|nsubjpass|uptake impaired|nmod|resistance resistance|compound|END_ENTITY	Glucose uptake in human brown adipose tissue is impaired upon fasting-induced insulin resistance .
3282149	0	Glucose	0,7	insulin	72,79	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|dep|effects effects|nmod|END_ENTITY	Glucose and amino_acid metabolism in aging man : differential effects of insulin .
3282149	6	Glucose	1159,1166	insulin	1284,1291	Glucose	Insulin	MESH:D005947	3630	Chemical	Gene	rates|amod|START_ENTITY lower|nsubj|rates lower|nmod|rates rates|amod|elderly elderly|nmod|infusion infusion|amod|young young|nmod|END_ENTITY	Glucose disposal rates adjusted for lean body mass -LRB- LBM -RRB- were lower in the elderly than in the young at the 6 , 10 , and 30 mU insulin infusion rates and similar in the two age groups in the 400 mU studies .
3322728	0	Glucose	0,7	insulin	45,52	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	responses|compound|START_ENTITY responses|nmod|relation relation|nmod|dose dose|compound|END_ENTITY	Glucose and insulin responses in relation to insulin dose and caloric intake 12 h after acute physical exercise in men with IDDM .
3514652	0	Glucose	0,7	insulin	51,58	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	storage|amod|START_ENTITY resistance|nsubj|storage resistance|compound|END_ENTITY	Glucose storage is a major determinant of in vivo `` insulin resistance '' in subjects with normal glucose tolerance .
382871	0	Glucose	0,7	insulin	50,57	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	technique|amod|START_ENTITY technique|dep|method method|acl|quantifying quantifying|dobj|secretion secretion|compound|END_ENTITY	Glucose clamp technique : a method for quantifying insulin secretion and resistance .
3886210	0	Glucose	0,7	insulin	44,51	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY immunoreactive|nsubj|tolerance immunoreactive|dobj|levels levels|compound|END_ENTITY	Glucose tolerance and plasma immunoreactive insulin levels in acromegalics before and after selective transsphenoidal surgery .
3905643	0	Glucose	0,7	insulin	54,61	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	transport|advmod|START_ENTITY transport|nmod|END_ENTITY	Glucose transport in adipocytes and its regulation by insulin .
3905735	0	Glucose	0,7	insulin	30,37	Glucose	insulin	MESH:D005947	280829(Tax:9913)	Chemical	Gene	response|amod|START_ENTITY response|nmod|END_ENTITY	Glucose response to exogenous insulin and kinetics of insulin metabolism in obese and lean heifers .
3905735	0	Glucose	0,7	insulin	54,61	Glucose	insulin	MESH:D005947	280829(Tax:9913)	Chemical	Gene	response|amod|START_ENTITY response|nmod|metabolism metabolism|compound|END_ENTITY	Glucose response to exogenous insulin and kinetics of insulin metabolism in obese and lean heifers .
3933479	0	Glucose	0,7	insulin	63,70	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	uptake|amod|START_ENTITY uptake|dep|studies studies|nmod|role role|nmod|END_ENTITY	Glucose uptake in isolated heart cells : studies on the role of insulin .
4375573	0	Glucose	14,21	insulin	37,44	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	stimulation|compound|START_ENTITY stimulation|nmod|secretion secretion|compound|END_ENTITY	-LSB- Proceedings : Glucose stimulation of insulin secretion and resultant changes of cyclic_AMP volumes in the Langerhans ' islands -RSB- .
521009	0	Glucose	0,7	insulin	68,75	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	infusion|compound|START_ENTITY infusion|nmod|determination determination|nmod|resistance resistance|compound|END_ENTITY	Glucose , insulin and somatostatin infusion for the determination of insulin resistance in liver_cirrhosis .
579023	1	Glucose	86,93	insulin	95,102	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	START_ENTITY|appos|levels levels|compound|END_ENTITY	I. Glucose , insulin and human growth_hormone levels during oral glucose tolerance tests .
6055423	0	Glucose	0,7	insulin	46,53	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|amod|START_ENTITY stimulated|nsubj|metabolism stimulated|nmod|END_ENTITY	Glucose metabolism in fat cells stimulated by insulin and dependent on sodium .
6254792	0	Glucose	0,7	insulin	70,77	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	oxidation|amod|START_ENTITY affected|nsubjpass|oxidation affected|nmod|END_ENTITY	Glucose oxidation in the ventromedial hypothalamus is not affected by insulin or ouabain but depressed by alloxan treatment .
6263727	0	Glucose	0,7	insulin	19,26	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	controlled|advmod|START_ENTITY controlled|nsubj|system system|compound|END_ENTITY	Glucose controlled insulin infusion system -LRB- Biostator -RRB- application during surgery for a presumed pancreatic_microinsulinoma .
6342138	0	Glucose	0,7	insulin	51,58	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	stimulation|amod|START_ENTITY stimulation|nmod|effect effect|nmod|END_ENTITY	Glucose stimulation of the antilipolytic effect of insulin in humans .
6357915	0	Glucose	0,7	insulin	120,127	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	utilization|amod|START_ENTITY utilization|dep|Evidence Evidence|nmod|defect defect|amod|reversible reversible|nmod|elevations elevations|nmod|END_ENTITY	Glucose utilization in Type 1 -LRB- insulin-dependent -RRB- diabetes : Evidence for a defect not reversible by acute elevations of insulin .
6361735	0	Glucose	0,7	insulin	9,16	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	kinetics|advmod|START_ENTITY kinetics|nsubj|END_ENTITY	Glucose , insulin and C-peptide kinetics during continuous ambulatory peritoneal dialysis .
6380207	0	Glucose	0,7	insulin	9,16	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	START_ENTITY|appos|pathology pathology|compound|END_ENTITY	Glucose , insulin and inner ear pathology .
6387483	0	Glucose	0,7	insulin	40,47	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	START_ENTITY|dobj|counterregulation counterregulation|nmod|END_ENTITY	Glucose counterregulation and waning of insulin in the Somogyi_phenomenon -LRB- posthypoglycemic hyperglycemia -RRB- .
6759265	0	Glucose	0,7	insulin	22,29	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	modulation|amod|START_ENTITY modulation|nmod|END_ENTITY	Glucose modulation of insulin and glucagon secretion in nondiabetic and diabetic man .
6802653	0	Glucose	0,7	insulin	46,53	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|amod|START_ENTITY tolerance|dep|role role|nmod|END_ENTITY	Glucose tolerance in the elderly : the role of insulin and its receptor .
6994381	0	Glucose	1,8	insulin	23,30	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	assimilation|compound|START_ENTITY assimilation|appos|secretion secretion|compound|END_ENTITY	-LSB- Glucose assimilation , insulin secretion and insulin sensititivy in psoriasis patients -RSB- .
6999010	0	Glucose	0,7	insulin	62,69	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	kinetics|amod|START_ENTITY kinetics|dep|fasting fasting|nmod|resistance resistance|compound|END_ENTITY	Glucose kinetics in leprechaunism : accelerated fasting due to insulin resistance .
7033268	0	Glucose	0,7	insulin	23,30	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	enhancement|amod|START_ENTITY enhancement|nmod|action action|compound|END_ENTITY	Glucose enhancement of insulin action : elevated glucose levels increase insulin stimulation of 2-deoxyglucose uptake in cultured human fibroblasts .
7033268	0	Glucose	0,7	insulin	72,79	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	enhancement|amod|START_ENTITY enhancement|dep|levels levels|dep|stimulation stimulation|compound|END_ENTITY	Glucose enhancement of insulin action : elevated glucose levels increase insulin stimulation of 2-deoxyglucose uptake in cultured human fibroblasts .
7037850	0	Glucose	0,7	insulin	59,66	Glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	ingestion|amod|START_ENTITY alters|nsubj|ingestion alters|dobj|extraction extraction|nmod|END_ENTITY	Glucose ingestion in dogs alters the hepatic extraction of insulin .
7041240	0	Glucose	0,7	insulin	26,33	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|amod|START_ENTITY tolerance|appos|END_ENTITY	Glucose tolerance , plasma insulin and C-peptide during chloroquine treatment of rheumatoid_arthritis .
7128971	0	Glucose	0,7	insulin	120,127	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|advmod|START_ENTITY control|nsubj|1 1|dep|patients patients|nmod|means means|nmod|feedback feedback|acl|controlled controlled|dobj|system system|compound|END_ENTITY	Glucose control in mobile type 1 -LRB- insulin-dependent -RRB- diabetic patients by means of a semi-automatic feedback controlled insulin infusion system .
7172986	0	Glucose	0,7	insulin	69,76	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	characteristics|amod|START_ENTITY characteristics|nmod|delivery delivery|compound|END_ENTITY	Glucose sensor characteristics for miniaturized portable closed-loop insulin delivery : a step toward implantation .
723635	0	Glucose	0,7	insulin	93,100	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|dep|responsiveness responsiveness|nmod|END_ENTITY	Glucose metabolism in intact man : the responsiveness of splanchnic and peripheral tissues to insulin .
7490534	0	Glucose	0,7	insulin	65,72	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|secretion secretion|compound|END_ENTITY	Glucose activation of acetyl-CoA_carboxylase in association with insulin secretion in a pancreatic beta-cell line .
7617595	0	Glucose	1,8	insulin	20,27	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY tolerance|appos|resistance resistance|compound|END_ENTITY	-LSB- Glucose tolerance , insulin resistance and arterial_hypertension in patients with obstructive_sleep_apnea_syndrome -RSB- .
7775622	0	Glucose	0,7	insulin	22,29	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	modulation|amod|START_ENTITY modulation|nmod|secretion secretion|compound|END_ENTITY	Glucose modulation of insulin and glucagon secretion is altered in impaired_glucose_tolerance .
7921578	0	Glucose	0,7	insulin	9,16	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolites|advmod|START_ENTITY metabolites|nsubj|END_ENTITY	Glucose , insulin and other plasma metabolites shortly after injury .
7958490	0	Glucose	0,7	insulin	41,48	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	potentiation|amod|START_ENTITY potentiation|nmod|secretion secretion|compound|END_ENTITY	Glucose potentiation of arginine-induced insulin secretion is impaired in subjects with a glucokinase Glu256Lys mutation .
8149032	0	Glucose	0,7	insulin	71,78	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	infusion|amod|START_ENTITY reduces|nsubj|infusion reduces|dobj|resistance resistance|compound|END_ENTITY	Glucose infusion instead of preoperative fasting reduces postoperative insulin resistance .
8252839	6	Glucose	924,931	insulin	973,980	Glucose	insulin	MESH:D005947	280829(Tax:9913)	Chemical	Gene	rates|amod|START_ENTITY rates|dep|responsiveness responsiveness|nmod|END_ENTITY	Glucose infusion rates -LRB- tissue responsiveness to insulin -RRB- were similar -LRB- 3.2 mg.kgBW-1 .
8552445	0	Glucose	0,7	insulin	23,30	Glucose	insulin	MESH:D005947	105613195	Chemical	Gene	suppression|amod|START_ENTITY suppression|nmod|secretion secretion|compound|END_ENTITY	Glucose suppression of insulin secretion in chronically hyperglycemic fetal sheep .
856655	0	Glucose	0,7	insulin	25,32	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|amod|START_ENTITY control|nmod|END_ENTITY	Glucose control of basal insulin secretion in diabetes .
9101062	0	Glucose	0,7	insulin	55,62	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|dep|role role|nmod|END_ENTITY	Glucose metabolism during exercise in man : the role of insulin and glucagon in the regulation of hepatic glucose production and gluconeogenesis .
9101063	0	Glucose	0,7	insulin	55,62	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|dep|role role|nmod|END_ENTITY	Glucose metabolism during exercise in man : the role of insulin in the regulation of glucose utilization .
9844735	0	Glucose	0,7	insulin	35,42	Glucose	insulin	MESH:D005947	3630	Chemical	Gene	secretion|amod|START_ENTITY secretion|compound|END_ENTITY	Glucose - and phorbol_ester-induced insulin secretion in human insulinoma cells -- association with protein kinase C activation .
19396426	0	Glucose	0,7	insulin-degrading_enzyme	55,79	Glucose	insulin-degrading enzyme	MESH:D005947	3416	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	Glucose inhibits the insulin-induced activation of the insulin-degrading_enzyme in HepG2 cells .
16052330	0	Glucose	0,7	insulin_receptor	81,97	Glucose	insulin receptor	MESH:D005947	24954(Tax:10116)	Chemical	Gene	concentration|amod|START_ENTITY regulate|nsubj|concentration regulate|dobj|expression expression|nmod|members members|compound|END_ENTITY	Glucose concentration and AMP-dependent kinase activation regulate expression of insulin_receptor family members in rat islets and INS-1E beta cells .
16731820	0	Glucose	0,7	insulin_receptor	32,48	Glucose	insulin receptor	MESH:D005947	16337(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Glucose regulates Foxo1 through insulin_receptor signaling in the pancreatic islet beta-cell .
1694071	0	Glucose	0,7	insulin_receptor	55,71	Glucose	insulin receptor	MESH:D005947	3643	Chemical	Gene	starvation|amod|START_ENTITY reduce|nsubj|starvation reduce|dobj|expression expression|compound|END_ENTITY	Glucose starvation and glycosylation inhibitors reduce insulin_receptor gene expression : characterization and potential mechanism in human cells .
19554259	0	Glucose	0,7	insulin_receptor	21,37	Glucose	insulin receptor	MESH:D005947	24954(Tax:10116)	Chemical	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Glucose binds to the insulin_receptor affecting the mutual affinity of insulin and its receptor .
2229049	0	Glucose	0,7	insulin_receptor	22,38	Glucose	insulin receptor	MESH:D005947	3643	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|affinity affinity|compound|END_ENTITY	Glucose regulation of insulin_receptor affinity in primary cultured adipocytes .
8549754	0	Glucose	0,7	insulin_receptor	52,68	Glucose	insulin receptor	MESH:D005947	24954(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Glucose - and insulin-induced phosphorylation of the insulin_receptor and its primary substrates IRS-1 and IRS-2 in rat pancreatic islets .
11399523	0	Glucose	0,7	interleukin-1_beta	20,38	Glucose	interleukin-1 beta	MESH:D005947	24494(Tax:10116)	Chemical	Gene	potentiates|amod|START_ENTITY potentiates|dep|IL-1_beta IL-1_beta|amod|END_ENTITY	Glucose potentiates interleukin-1_beta -LRB- IL-1_beta -RRB- - induced p38 mitogen-activated protein kinase activity in rat pancreatic islets of Langerhans .
12702735	0	Glucose	0,7	interleukin-6	29,42	Glucose	interleukin-6	MESH:D005947	3569	Chemical	Gene	ingestion|compound|START_ENTITY attenuates|nsubj|ingestion attenuates|dobj|release release|amod|END_ENTITY	Glucose ingestion attenuates interleukin-6 release from contracting skeletal muscle in humans .
15145956	0	Glucose	0,7	interleukin-8	18,31	Glucose	interleukin-8	MESH:D005947	20309(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|amod|END_ENTITY	Glucose regulates interleukin-8 production in aortic endothelial cells through activation of the p38 mitogen-activated protein kinase pathway in diabetes .
10720074	0	Glucose	0,7	leptin	64,70	Glucose	leptin	MESH:D005947	3952	Chemical	Gene	metabolism|amod|START_ENTITY determinant|nsubj|metabolism determinant|nmod|secretion secretion|compound|END_ENTITY	Glucose metabolism rather than insulin is a main determinant of leptin secretion in humans .
17332528	0	Glucose	0,7	leptin	160,166	Glucose	leptin	MESH:D005947	3952	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|neurons neurons|acl|expressing expressing|dobj|proopiomelanocortin proopiomelanocortin|dep|effects effects|nmod|END_ENTITY	Glucose regulates AMP-activated protein kinase activity and gene expression in clonal , hypothalamic neurons expressing proopiomelanocortin : additive effects of leptin or insulin .
18645661	0	Glucose	1,8	leptin	97,103	Glucose	leptin	MESH:D005947	25608(Tax:10116)	Chemical	Gene	submitted|nsubj|START_ENTITY submitted|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Glucose and insulin levels in Wistar_rats submitted to high fat diet and treatment with mimetic leptin peptides -RSB- .
25385184	0	Glucose	0,7	mTOR	50,54	Glucose	mTOR	MESH:D005947	21977(Tax:10090)	Chemical	Gene	uptake|amod|START_ENTITY dependent|nsubj|uptake dependent|nmod|translocation translocation|compound|END_ENTITY	Glucose uptake in brown fat cells is dependent on mTOR complex 2-promoted GLUT1 translocation .
19305497	0	Glucose	0,7	mTORC1	109,115	Glucose	mTORC1	MESH:D005947	382056(Tax:10090)	Chemical	Gene	amplifies|nsubj|START_ENTITY amplifies|nmod|beta-cells beta-cells|nmod|activation activation|nmod|END_ENTITY	Glucose amplifies fatty_acid-induced endoplasmic_reticulum_stress in pancreatic beta-cells via activation of mTORC1 .
25288788	0	Glucose	5,12	mTORC1	90,96	Glucose	mTORC1	MESH:D005947	382056(Tax:10090)	Chemical	Gene	Forces|nsubj|START_ENTITY Forces|nmod|Activate Activate|nummod|END_ENTITY	High Glucose Forces a Positive Feed Back Loop Connecting Akt Kinase and FoxO1 to Activate mTORC1 for Mesangial Cell Hypertrophy and Matrix Protein Expression .
25414024	1	Glucose	140,147	mTORC2	119,125	Glucose	mTORC2	MESH:D005947	74343(Tax:10090)	Chemical	Gene	Uptake|compound|START_ENTITY END_ENTITY|dobj|Uptake	Improving Type 2 Diabetes Through a Distinct Adrenergic Signaling Pathway Involving mTORC2 That Mediates Glucose Uptake in Skeletal Muscle .
18801338	0	Glucose	0,7	microRNA-1	48,58	Glucose	microRNA-1	MESH:D005947	100314077(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|apoptosis apoptosis|nmod|cardiomyocytes cardiomyocytes|nmod|END_ENTITY	Glucose induces apoptosis of cardiomyocytes via microRNA-1 and IGF-1 .
6373862	0	Glucose	0,7	milk	38,42	Glucose	milk	MESH:D005947	100532204	Chemical	Gene	levels|amod|START_ENTITY levels|nmod|END_ENTITY	Glucose levels in normal and mastitic milk .
16644033	0	Glucose	0,7	nerve_growth_factor	36,55	Glucose	nerve growth factor	MESH:D005947	310738(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Glucose regulates expression of the nerve_growth_factor -LRB- NGF -RRB- receptors TrkA and p75NTR in rat islets and INS-1E beta-cells .
5639608	0	Glucose	0,7	nerve_growth_factor	51,70	Glucose	nerve growth factor	MESH:D005947	4803	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|dep|effect effect|nmod|-RSB- -RSB-|compound|END_ENTITY	Glucose metabolism in embryonic ganglia : effect of nerve_growth_factor -LSB- NGF -RSB- and insulin .
25898949	0	Glucose	0,7	neurotensin	19,30	Glucose	neurotensin	MESH:D005947	299757(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|compound|END_ENTITY	Glucose stimulates neurotensin secretion from the rat small intestine by mechanisms involving SGLT1 and GLUT2 leading to cell depolarization and calcium influx .
12502500	0	Glucose	0,7	orexin-a	33,41	Glucose	orexin-a	MESH:D005947	25723(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|release release|nmod|END_ENTITY	Glucose regulates the release of orexin-a from the endocrine pancreas .
15502635	0	Glucose	0,7	p130Cas	47,54	Glucose	p130Cas	MESH:D005947	25414(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|END_ENTITY	Glucose stimulates the association of Crk with p130Cas in pancreatic beta cells .
11399523	0	Glucose	0,7	p38	59,62	Glucose	p38	MESH:D005947	81649(Tax:10116)	Chemical	Gene	potentiates|amod|START_ENTITY potentiates|dep|activity activity|amod|END_ENTITY	Glucose potentiates interleukin-1_beta -LRB- IL-1_beta -RRB- - induced p38 mitogen-activated protein kinase activity in rat pancreatic islets of Langerhans .
15145956	0	Glucose	0,7	p38	97,100	Glucose	p38	MESH:D005947	26416(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|activation activation|nmod|pathway pathway|amod|END_ENTITY	Glucose regulates interleukin-8 production in aortic endothelial cells through activation of the p38 mitogen-activated protein kinase pathway in diabetes .
9916130	0	Glucose	0,7	p38	30,33	Glucose	p38	MESH:D005947	81649(Tax:10116)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|kinase kinase|amod|END_ENTITY	Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways .
23102272	0	Glucose	0,7	p53	55,58	Glucose	p53	MESH:D005947	22060(Tax:10090)	Chemical	Gene	Tolerance|compound|START_ENTITY Linked|nsubjpass|Tolerance Linked|nmod|Dose Dose|nmod|Domain Domain|compound|END_ENTITY	Glucose Tolerance in Mice is Linked to the Dose of the p53 Transactivation Domain .
12409145	0	Glucose	0,7	plasminogen_activator_inhibitor-1	20,53	Glucose	plasminogen activator inhibitor-1	MESH:D005947	24617(Tax:10116)	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Glucose upregulates plasminogen_activator_inhibitor-1 gene expression in vascular smooth muscle cells .
3030804	0	Glucose	0,7	preproinsulin	18,31	Glucose	preproinsulin	MESH:D005947	3630	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|levels levels|amod|END_ENTITY	Glucose regulates preproinsulin messenger RNA levels in a clonal cell line of simian_virus_40-transformed B cells .
3287379	0	Glucose	0,7	proinsulin	19,29	Glucose	proinsulin	MESH:D005947	3630	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|biosynthesis biosynthesis|compound|END_ENTITY	Glucose stimulates proinsulin biosynthesis by a dose-dependent recruitment of pancreatic beta cells .
6749627	0	Glucose	0,7	prolactin	52,61	Glucose	prolactin	MESH:D005947	24683(Tax:10116)	Chemical	Gene	tolerance|amod|START_ENTITY elevated|nsubj|tolerance elevated|xcomp|circulating circulating|dobj|levels levels|compound|END_ENTITY	Glucose tolerance in rats with elevated circulating prolactin levels .
7711007	0	Glucose	0,7	prolactin	41,50	Glucose	prolactin	MESH:D005947	5617	Chemical	Gene	administration|amod|START_ENTITY modulate|nsubj|administration modulate|dobj|response response|compound|END_ENTITY	Glucose administration does not modulate prolactin response to exercise , TRH or haloperidol injection .
11007796	0	Glucose	0,7	proline-rich_tyrosine_kinase-2	99,129	Glucose	proline-rich tyrosine kinase-2	MESH:D005947	2185	Chemical	Gene	activates|nsubj|START_ENTITY activates|nmod|END_ENTITY	Glucose activates mitogen-activated protein kinase -LRB- extracellular_signal-regulated_kinase -RRB- through proline-rich_tyrosine_kinase-2 and the Glut1 glucose transporter .
23207906	0	Glucose	0,7	protein_targeting_to_glycogen	16,45	Glucose	protein targeting to glycogen	MESH:D005947	5507	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Glucose induces protein_targeting_to_glycogen in hepatocytes by fructose_2 ,6 - bisphosphate-mediated recruitment of MondoA to the promoter .
17509747	0	Glucose	0,7	protein_tyrosine_phosphatase_1B	17,48	Glucose	protein tyrosine phosphatase 1B	MESH:D005947	5770	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|transcription transcription|amod|END_ENTITY	Glucose enhances protein_tyrosine_phosphatase_1B gene transcription in hepatocytes .
17263682	0	Glucose	0,7	pyruvate_carboxylase	63,83	Glucose	pyruvate carboxylase	MESH:D005947	25104(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|dep|estimation estimation|nmod|flux flux|amod|END_ENTITY	Glucose metabolism after traumatic_brain_injury : estimation of pyruvate_carboxylase and pyruvate dehydrogenase flux by mass isotopomer analysis .
20001964	0	Glucose	0,7	pyruvate_carboxylase	34,54	Glucose	pyruvate carboxylase	MESH:D005947	25104(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Glucose induces expression of rat pyruvate_carboxylase through a carbohydrate response element in the distal gene promoter .
9627098	0	Glucose	0,7	renin	19,24	Glucose	renin	MESH:D005947	24715(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|compound|END_ENTITY	Glucose stimulates renin secretion via adrenergic mechanisms in the rat .
11572020	8	Glucose	1070,1077	secretin	1228,1236	Glucose	Secretin	MESH:D005947	24769(Tax:10116)	Chemical	Gene	administration|amod|START_ENTITY increased|nsubj|administration increased|nmod|animals animals|acl|infused infused|nmod|rats rats|acl|given given|dobj|dose dose|nmod|END_ENTITY	Glucose administration increased duodenal blood flow in animals infused with saline and both duodenal_and_colonic_blood_flow in rats given the lowest dose of secretin .
6108275	0	Glucose	0,7	somatostatin	23,35	Glucose	somatostatin	MESH:D005947	24797(Tax:10116)	Chemical	Gene	stimulation|amod|START_ENTITY stimulation|nmod|END_ENTITY	Glucose stimulation of somatostatin and insulin release from the isolated , perfused rat pancreas .
11720139	0	Glucose	0,7	thrombin	58,66	Glucose	thrombin	MESH:D005947	2147	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|fatty_acids fatty_acids|nmod|END_ENTITY	Glucose suppresses the enhancement by free fatty_acids on thrombin - stimulated production of prostacyclin in cultured aortic endothelial cells .
8232303	0	Glucose	0,7	transforming_growth_factor-alpha	22,54	Glucose	transforming growth factor-alpha	MESH:D005947	24827(Tax:10116)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Glucose regulation of transforming_growth_factor-alpha expression is mediated by products of the hexosamine biosynthesis pathway .
23717413	0	Glucose	0,7	transglutaminase_2	31,49	Glucose	transglutaminase 2	MESH:D005947	21817(Tax:10090)	Chemical	Gene	homeostasis|amod|START_ENTITY independent|nsubj|homeostasis independent|advmod|END_ENTITY	Glucose homeostasis in mice is transglutaminase_2 independent .
15640157	0	Glucose	0,7	vascular_endothelial_growth_factor	48,82	Glucose	vascular endothelial growth factor	MESH:D005947	7422	Chemical	Gene	deprivation|compound|START_ENTITY increases|nsubj|deprivation increases|dobj|stability stability|nmod|END_ENTITY	Glucose deprivation increases mRNA stability of vascular_endothelial_growth_factor through activation of AMP-activated_protein_kinase in DU145 prostate_carcinoma .
24223971	0	Glucose-6-phosphate	0,19	G6PD	35,39	Glucose-6-phosphate	G6PD	MESH:D019298	2539	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	Glucose-6-phosphate dehydrogenase -LRB- G6PD -RRB- - deficient epithelial cells are less tolerant to infection by Staphylococcus_aureus .
8020625	0	Glucose_phosphate	0,17	GPI	29,32	Glucose phosphate	GPI	CHEBI:21008	2821	Chemical	Gene	isomerase|amod|START_ENTITY isomerase|appos|END_ENTITY	Glucose_phosphate isomerase -LRB- GPI -RRB- `` Morcone '' : a new variant from Italy .
26973671	0	Glucosinolate	16,29	Cytochrome_P450_83A1_Monooxygenase	50,84	Glucosinolate	Cytochrome P450 83A1 Monooxygenase	CHEBI:24279	827011(Tax:3702)	Chemical	Gene	Accumulation|compound|START_ENTITY Accumulation|compound|END_ENTITY	Mutation of the Glucosinolate Biosynthesis Enzyme Cytochrome_P450_83A1_Monooxygenase Increases Camalexin Accumulation and Powdery Mildew Resistance .
1355388	0	Glutamate	0,9	AP4	44,47	Glutamate	AP4	CHEBI:29987	445541(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	Glutamate release and presynaptic action of AP4 during inspiratory drive to phrenic motoneurons .
12106087	0	Glutamate	66,75	CA1	124,127	Glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	Applications|compound|START_ENTITY Evoked|nmod|Applications Evoked|nmod|Lacunosum-Moleculare Lacunosum-Moleculare|nmod|Cells Cells|compound|END_ENTITY	Bicuculline - and Phaclofen-Resistant Hyperpolarizations Evoked by Glutamate Applications to Stratum Lacunosum-Moleculare in CA1 Pyramidal Cells of the Rat Hippocampus In Vitro .
1282929	0	Glutamate	0,9	CA1	53,56	Glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	channels|amod|START_ENTITY channels|nmod|patches patches|nmod|END_ENTITY	Glutamate receptor channels in isolated patches from CA1 and CA3 pyramidal cells of rat hippocampal slices .
26446209	0	Glutamate	108,117	CA1	33,36	Glutamate	CA1	D018698	310218(Tax:10116)	Chemical	Gene	Receptors|compound|START_ENTITY Interactions|nmod|Receptors Induction|dep|Interactions Induction|nmod|LTP LTP|nmod|Interneurons Interneurons|compound|END_ENTITY	Induction of Anti-Hebbian LTP in CA1 Stratum Oriens Interneurons : Interactions between Group I Metabotropic Glutamate Receptors and M1 Muscarinic Receptors .
7687331	0	Glutamate	0,9	CA1	117,120	Glutamate	CA1	CHEBI:29987	759	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|frequency frequency|nmod|openings openings|nmod|neurons neurons|compound|END_ENTITY	Glutamate induces long-term increase in the frequency of single N-methyl-D-aspartate channel openings in hippocampal CA1 neurons examined in situ .
7823086	0	Glutamate	0,9	CA1	93,96	Glutamate	CA1	CHEBI:29987	759	Chemical	Gene	receptors|amod|START_ENTITY increase|nsubj|receptors increase|dobj|Ca Ca|dep|current current|nmod|neurons neurons|nummod|END_ENTITY	Glutamate metabotropic receptors increase a Ca -LRB- 2 + -RRB- - activated nonspecific cationic current in CA1 hippocampal neurons .
8097032	0	Glutamate	0,9	CA1	85,88	Glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	enhance|nsubj|START_ENTITY enhance|nmod|neurons neurons|nummod|END_ENTITY	Glutamate and theta-rhythm stimulation selectively enhance NMDA component of EPSC in CA1 neurons of young rats .
9013789	0	Glutamate	0,9	CA1	100,103	Glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY correlates|nsubj|release correlates|nmod|region region|compound|END_ENTITY	Glutamate release correlates with brain-derived_neurotrophic_factor and trkB mRNA expression in the CA1 region of rat hippocampus .
12106103	0	Glutamate	57,66	CA3	74,77	Glutamate	CA3	CHEBI:29987	54232(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|Neurons Neurons|compound|END_ENTITY	Galanin and Glibenclamide Modulate the Anoxic Release of Glutamate in Rat CA3 Hippocampal Neurons .
12106302	0	Glutamate	61,70	CA3	88,91	Glutamate	CA3	CHEBI:29987	54232(Tax:10116)	Chemical	Gene	Receptors|compound|START_ENTITY Receptors|nmod|Cells Cells|compound|END_ENTITY	Reduction of Potassium Conductances Mediated by Metabotropic Glutamate Receptors in Rat CA3 Pyramidal Cells Does Not Require Protein Kinase C or Protein_Kinase_A .
26669191	0	Glutamate	87,96	Cx_43	60,65	Glutamate	Cx 43	D018698	24392(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of Electroacupuncture Intervention on Expression of Cx_43 and Concentration of Glutamate in the Striatum of Rats with Parkinson 's _ Disease -RSB- .
10931942	0	Glutamate	0,9	EAAC1	62,67	Glutamate	EAAC1	CHEBI:29987	6505	Chemical	Gene	translocation|amod|START_ENTITY translocation|nmod|END_ENTITY	Glutamate translocation of the neuronal glutamate transporter EAAC1 occurs within milliseconds .
14749132	0	Glutamate	0,9	EAAT1	37,42	Glutamate	EAAT1	CHEBI:29987	6507	Chemical	Gene	transporters|amod|START_ENTITY transporters|dep|decrease decrease|nummod|END_ENTITY	Glutamate transporters in platelets : EAAT1 decrease in aging and in Alzheimer 's _ disease .
11071482	0	Glutamate	0,9	EAAT2	22,27	Glutamate	EAAT2	CHEBI:29987	6506	Chemical	Gene	variants|compound|START_ENTITY variants|compound|END_ENTITY	Glutamate transporter EAAT2 splice variants occur not only in ALS , but also in AD and controls .
17122424	0	Glutamate	51,60	EAAT2	76,81	Glutamate	EAAT2	CHEBI:29987	6506	Chemical	Gene	Upregulation|compound|START_ENTITY Upregulation|appos|END_ENTITY	Pharmacological Induction of Ischemic Tolerance by Glutamate Transporter-1 -LRB- EAAT2 -RRB- Upregulation .
18314905	0	Glutamate	0,9	EAAT2	22,27	Glutamate	EAAT2	CHEBI:29987	6506	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Glutamate transporter EAAT2 expression is up-regulated in reactive astrocytes in human periventricular_leukomalacia .
26628388	0	Glutamate	57,66	EAAT2	51,56	Glutamate	EAAT2	D018698	20511(Tax:10090)	Chemical	Gene	Transporter|compound|START_ENTITY Transporter|compound|END_ENTITY	Seladin-1 / DHCR24 Is Neuroprotective by Associating EAAT2 Glutamate Transporter to Lipid Rafts in Experimental Stroke .
23049999	0	Glutamate	0,9	EAAT4	23,28	Glutamate	EAAT4	CHEBI:29987	20513(Tax:10090)	Chemical	Gene	transporters|nsubj|START_ENTITY transporters|ccomp|expressed expressed|nsubjpass|END_ENTITY	Glutamate transporters EAAT4 and EAAT5 are expressed in vestibular hair cells and calyx endings .
19997873	0	Glutamate	0,9	EGFR	34,38	Glutamate	EGFR	CHEBI:29987	1956	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Glutamate promotes cell growth by EGFR signaling on U-87MG human glioblastoma cell line .
18022816	0	Glutamate	0,9	ERK1/2	53,59	Glutamate	ERK1/2	CHEBI:29987	5595;5594	Chemical	Gene	accelerates|nsubj|START_ENTITY accelerates|nmod|activation activation|nummod|END_ENTITY	Glutamate accelerates RPE cell proliferation through ERK1/2 activation via distinct receptor-specific mechanisms .
11746393	0	Glutamate	0,9	FAK	26,29	Glutamate	FAK	CHEBI:29987	396416(Tax:9031)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Glutamate activates PP125 -LRB- FAK -RRB- through AMPA/kainate receptors in Bergmann glia .
22304712	0	Glutamate	0,9	GCPII	71,76	Glutamate	GCPII	CHEBI:29987	2346	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|compound|END_ENTITY	Glutamate in CNS neurodegeneration and cognition and its regulation by GCPII inhibition .
7488747	0	Glutamate	0,9	GDNF	24,28	Glutamate	GDNF	CHEBI:29987	25453(Tax:10116)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Glutamate regulation of GDNF gene expression in the striatum and primary striatal astrocytes .
16647773	0	Glutamate	0,9	GLAST	144,149	Glutamate	GLAST	CHEBI:29987	20512(Tax:10090)	Chemical	Gene	transporters|nsubj|START_ENTITY transporters|ccomp|regulate regulate|dobj|death death|dep|study study|acl|using using|nmod|mice mice|acl|lacking lacking|dobj|END_ENTITY	Glutamate transporters GLAST and EAAT4 regulate postischemic Purkinje cell death : an in vivo study using a cardiac_arrest model in mice lacking GLAST or EAAT4 .
16647773	0	Glutamate	0,9	GLAST	23,28	Glutamate	GLAST	CHEBI:29987	20512(Tax:10090)	Chemical	Gene	transporters|nsubj|START_ENTITY transporters|ccomp|regulate regulate|nsubj|END_ENTITY	Glutamate transporters GLAST and EAAT4 regulate postischemic Purkinje cell death : an in vivo study using a cardiac_arrest model in mice lacking GLAST or EAAT4 .
9051792	0	Glutamate	0,9	GLAST	62,67	Glutamate	GLAST	CHEBI:29987	6507	Chemical	Gene	receptor|amod|START_ENTITY agonists|nsubj|receptor agonists|dobj|END_ENTITY	Glutamate receptor agonists up-regulate glutamate transporter GLAST in astrocytes .
22220274	0	Glutamate	0,9	GLT-1	22,27	Glutamate	GLT-1	CHEBI:29987	6506	Chemical	Gene	Nociception|compound|START_ENTITY Nociception|compound|END_ENTITY	Glutamate Transporter GLT-1 Upregulation Attenuates Visceral Nociception and Hyperalgesia via Spinal Mechanisms Not Related to Anti-Inflammatory or Probiotic Effects .
25274824	0	Glutamate	22,31	GLT-1	7,12	Glutamate	GLT-1	CHEBI:29987	29482(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|EAAT2 EAAT2|appos|END_ENTITY	EAAT2 -LRB- GLT-1 ; slc1a2 -RRB- Glutamate Transporters Reconstituted in Liposomes Argues against Heteroexchange Being Substantially Faster than Net Uptake .
26483543	0	Glutamate	133,142	GLT-1	155,160	Glutamate	GLT-1	D018698	6506	Chemical	Gene	SLC1A2|compound|START_ENTITY SLC1A2|compound|END_ENTITY	The Hydroxyl Side Chain of a Highly Conserved Serine Residue is Required for Cation Selectivity and Substrate Transport in the Glial Glutamate Transporter GLT-1 / SLC1A2 .
9843150	0	Glutamate	0,9	GLT-1	78,83	Glutamate	GLT-1	CHEBI:29987	6506	Chemical	Gene	transport|amod|START_ENTITY transport|dep|presence presence|nmod|immunoreactivity immunoreactivity|compound|END_ENTITY	Glutamate transport in cultures from developing avian cerebellum : presence of GLT-1 immunoreactivity in Purkinje neurons .
25492561	0	Glutamate	54,63	GLT1	76,80	Glutamate	GLT1	CHEBI:29987	6506	Chemical	Gene	Function|compound|START_ENTITY Function|compound|END_ENTITY	Transplantation of Glial Progenitors That Overexpress Glutamate Transporter GLT1 Preserves Diaphragm Function Following Cervical SCI .
16526023	0	Glutamate	0,9	GRIA1	40,45	Glutamate	GRIA1	CHEBI:29987	2890	Chemical	Gene	subunit|compound|START_ENTITY subunit|dep|gene gene|appos|END_ENTITY	Glutamate AMPA receptor subunit 1 gene -LRB- GRIA1 -RRB- and DSM-IV-TR schizophrenia : a pilot case-control association study in an Italian sample .
19324536	0	Glutamate	0,9	GRIN2B	25,31	Glutamate	GRIN2B	CHEBI:29987	2904	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Glutamate receptor gene -LRB- GRIN2B -RRB- associated with reduced anterior cingulate glutamatergic concentration in pediatric obsessive-compulsive_disorder .
24412196	0	Glutamate	0,9	GluR1	57,62	Glutamate	GluR1	D018698	14799(Tax:10090)	Chemical	Gene	transporter|amod|START_ENTITY regulates|nsubj|transporter regulates|dobj|trafficking trafficking|compound|END_ENTITY	Glutamate transporter type 3 regulates mouse hippocampal GluR1 trafficking .
25466458	0	Glutamate	72,81	GluR1	92,97	Glutamate	GluR1	CHEBI:29987	2890	Chemical	Gene	Receptor|compound|START_ENTITY Receptor|appos|END_ENTITY	Determination of binding capacity and adsorption enthalpy between Human Glutamate Receptor -LRB- GluR1 -RRB- peptide fragments and kynurenic_acid by surface plasmon resonance experiments .
9581975	0	Glutamate	0,9	GluR1	19,24	Glutamate	GluR1	CHEBI:29987	14799(Tax:10090)	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Glutamate receptor GluR1 expression is altered selectively by chronic audiogenic_seizures in the Frings mouse brain .
14559151	0	Glutamate	0,9	GluR2	56,61	Glutamate	GluR2	CHEBI:29987	2891	Chemical	Gene	editing|compound|START_ENTITY editing|dep|analysis analysis|nmod|END_ENTITY	Glutamate receptor RNA editing : a molecular analysis of GluR2 , GluR5 and GluR6 in human brain tissues and in NT2 cells following in vitro neural differentiation .
17207582	0	Glutamate	0,9	GluR2	139,144	Glutamate	GluR2	CHEBI:29987	29627(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|advcl|regulate regulate|dobj|expression expression|nmod|END_ENTITY	Glutamate stimulates glutamate_receptor_interacting_protein_1 degradation by ubiquitin-proteasome system to regulate surface expression of GluR2 .
9254673	0	Glutamate	0,9	GluR5	28,33	Glutamate	GluR5	CHEBI:29987	29559(Tax:10116)	Chemical	Gene	subunits|amod|START_ENTITY subunits|amod|END_ENTITY	Glutamate receptor subunits GluR5 and KA-2 are coexpressed in rat trigeminal_ganglion neurons .
19224535	0	Glutamate	0,9	GluR6	56,61	Glutamate	GluR6	CHEBI:29987	2898	Chemical	Gene	receptors|amod|START_ENTITY receptors|dep|END_ENTITY	Glutamate receptors on myelinated spinal cord axons : I. GluR6 kainate receptors .
12231779	0	Glutamate	46,55	Glutamine_Synthetase	0,20	Glutamate	Glutamine Synthetase	CHEBI:29987	542746(Tax:4577)	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Glutamine_Synthetase and Ferredoxin-Dependent Glutamate Synthase Expression in the Maize -LRB- Zea_mays -RRB- Root Primary Response to Nitrate -LRB- Evidence for an Organ-Specific Response -RRB- .
20807514	0	Glutamate	0,9	GnRH	24,28	Glutamate	GnRH	CHEBI:29987	14714(Tax:10090)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Glutamate regulation of GnRH neuron excitability .
19075349	0	Glutamate	0,9	IL-10	37,42	Glutamate	IL-10	CHEBI:29987	3586	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|secretion secretion|nmod|END_ENTITY	Glutamate decreases the secretion of IL-10 by peripheral blood lymphocytes in persons with autoimmune_thyroiditis .
11839523	0	Glutamate	0,9	NR2B	61,65	Glutamate	NR2B	CHEBI:29987	2904	Chemical	Gene	receptors|amod|START_ENTITY receptors|dep|subunits subunits|compound|END_ENTITY	Glutamate receptors and persistent pain : targeting forebrain NR2B subunits .
22001275	0	Glutamate	11,20	NR2B	61,65	Glutamate	NR2B	CHEBI:29987	2904	Chemical	Gene	Signaling|compound|START_ENTITY Signaling|nmod|END_ENTITY	WITHDRAWN : Glutamate Attenuates IGF-1 Receptor Signaling via NR2B containing NMDA Receptors 3 and neuronal Nitric_Oxide Synthase .
15234189	0	Glutamate	0,9	P-glycoprotein	23,37	Glutamate	P-glycoprotein	CHEBI:29987	287115(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Glutamate up-regulates P-glycoprotein expression in rat brain microvessel endothelial cells by an NMDA receptor-mediated mechanism .
26195627	0	Glutamate	22,31	Rhodopsin_1	69,80	Glutamate	Rhodopsin 1	D018698	42367(Tax:7227)	Chemical	Gene	Analysis|nmod|START_ENTITY Analysis|nmod|END_ENTITY	Analysis of Conserved Glutamate and Aspartate Residues in Drosophila Rhodopsin_1 and Their Influence on Spectral Tuning .
20155310	0	Glutamate	0,9	SLC1A1	28,34	Glutamate	SLC1A1	CHEBI:29987	6505	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Glutamate transporter gene -LRB- SLC1A1 -RRB- single nucleotide polymorphism -LRB- rs301430 -RRB- and repetitive_behaviors and anxiety in children with autism_spectrum_disorder .
25749299	0	Glutamate	25,34	TAAR1	0,5	Glutamate	TAAR1	D018698	111174(Tax:10090)	Chemical	Gene	Function|compound|START_ENTITY Function|compound|END_ENTITY	TAAR1 Modulates Cortical Glutamate NMDA Receptor Function .
17304580	0	Glutamate	0,9	c-Fos	144,149	Glutamate	c-Fos	CHEBI:29987	314322(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY associated|nsubj|receptors associated|parataxis|inhibits inhibits|dobj|expression expression|amod|END_ENTITY	Glutamate and metabotropic glutamate receptors associated with innervation of the uterine cervix during pregnancy : receptor antagonism inhibits c-Fos expression in rat lumbosacral spinal cord at parturition .
15522236	0	Glutamate	0,9	c-fos	42,47	Glutamate	c-fos	CHEBI:29987	2353	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Glutamate receptor-mediated regulation of c-fos expression in cultured microglia .
17120244	0	Glutamate	0,9	c-fos	20,25	Glutamate	c-fos	CHEBI:29987	314322(Tax:10116)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Glutamate activates c-fos in glial cells via a novel mechanism involving the glutamate receptor subtype mGlu5 and the transcriptional repressor DREAM .
8845939	0	Glutamate	0,9	c-fos	18,23	Glutamate	c-fos	CHEBI:29987	2353	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Glutamate induces c-fos proto-oncogene expression and inhibits proliferation in oligodendrocyte progenitors : receptor characterization .
12739245	0	Glutamate	0,9	caspase-3	19,28	Glutamate	caspase-3	CHEBI:29987	25402(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|immunoreactivity immunoreactivity|amod|END_ENTITY	Glutamate enhances caspase-3 immunoreactivity in cultured spinal cord neurons of newborn rats .
21458428	0	Glutamate	0,9	connexin_43	26,37	Glutamate	connexin 43	CHEBI:29987	2697	Chemical	Gene	release|nsubj|START_ENTITY release|nmod|END_ENTITY	Glutamate release through connexin_43 by cultured astrocytes in a stimulated hypertonicity model .
15895827	0	Glutamate	0,9	dystrophin-71	20,33	Glutamate	dystrophin-71	CHEBI:29987	13405(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|levels levels|amod|END_ENTITY	Glutamate regulates dystrophin-71 levels in glia cells .
7981632	0	Glutamate	0,9	glial_fibrillary_acidic_protein	44,75	Glutamate	glial fibrillary acidic protein	CHEBI:29987	24387(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Glutamate stimulates the phosphorylation of glial_fibrillary_acidic_protein in slices of immature rat hippocampus via a metabotropic receptor .
25373904	0	Glutamate	0,9	insulin	93,100	Glutamate	insulin	D018698	3630	Chemical	Gene	acts|nsubj|START_ENTITY acts|nmod|signal signal|acl|linking linking|advcl|incretin/cAMP incretin/cAMP|advcl|amplify amplify|dobj|secretion secretion|compound|END_ENTITY	Glutamate acts as a key signal linking glucose metabolism to incretin/cAMP action to amplify insulin secretion .
25950516	0	Glutamate	25,34	mGlu3	62,67	Glutamate	mGlu3	D018698	108069(Tax:10090)	Chemical	Gene	Deletion|nmod|START_ENTITY Receptors|nsubj|Deletion Receptors|dobj|2 2|appos|END_ENTITY	Deletion of Metabotropic Glutamate Receptors 2 and 3 -LRB- mGlu2 _ mGlu3 -RRB- in Mice Disrupts Sleep and Wheel-Running Activity , and Increases the Sensitivity of the Circadian System to Light .
23115168	0	Glutamate	0,9	mGluR1	74,80	Glutamate	mGluR1	CHEBI:29987	14799(Tax:10090)	Chemical	Gene	receptor|nsubj|START_ENTITY receptor|nmod|END_ENTITY	Glutamate receptor 2 associates with metabotropic glutamate receptor 1 -LRB- mGluR1 -RRB- , protein kinase Cy , and canonical transient receptor potential 3 and regulates mGluR1-mediated synaptic transmission in cerebellar Purkinje neurons .
26076143	0	Glutamate	61,70	mGluR1	91,97	Glutamate	mGluR1	D018698	14799(Tax:10090)	Chemical	Gene	Subtype|compound|START_ENTITY Subtype|appos|END_ENTITY	Improved Visualization and Specific Binding for Metabotropic Glutamate Receptor Subtype 1 -LRB- mGluR1 -RRB- Using -LSB- 11C -RSB- ITMM with Ultra-High Specific Activity in Small-Animal PET .
25657067	0	Glutamate	30,39	mGluR2/3	51,59	Glutamate	mGluR2/3	CHEBI:29987	108068;108069;14800;53623	Chemical	Gene	Receptors|compound|START_ENTITY Receptors|appos|END_ENTITY	Role of Group II Metabotropic Glutamate Receptors -LRB- mGluR2/3 -RRB- Blockade on Long-Term Potentiation in the Dentate Gyrus Region of Hippocampus in Rats Fed with High-Fat Diet .
25829143	0	Glutamate	31,40	mGluR5	100,106	Glutamate	mGluR5	D018698	14805(Tax:10090)	Chemical	Gene	mGluR1|compound|START_ENTITY Currents|nsubj|mGluR1 Currents|nmod|Activating Activating|nummod|END_ENTITY	Cocaine Decreases Metabotropic Glutamate Receptor mGluR1 Currents in Dopamine Neurons by Activating mGluR5 .
26059827	0	Glutamate	75,84	mGluR5	97,103	Glutamate	mGluR5	D018698	14805(Tax:10090)	Chemical	Gene	Receptor|compound|START_ENTITY Treated|nmod|Receptor Skin_Lesions|nmod|Treated Skin_Lesions|appos|END_ENTITY	Drug-induced Skin_Lesions in Cynomolgus Macaques Treated with Metabotropic Glutamate Receptor 5 -LRB- mGluR5 -RRB- Negative Allosteric Modulators .
25386457	0	Glutamate	17,26	mGluR_7	39,46	Glutamate	mGluR 7	CHEBI:29987	14807(Tax:10090)	Chemical	Gene	Receptor|compound|START_ENTITY Receptor|dep|END_ENTITY	Can Metabotropic Glutamate Receptor 7 -LRB- mGluR_7 -RRB- be a Novel Target for Analgesia ?
20138844	0	Glutamate	0,9	neurotrophic_factor	18,37	Glutamate	neurotrophic factor	CHEBI:29987	4908	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|compound|END_ENTITY	Glutamate induces neurotrophic_factor production from microglia via protein kinase C pathway .
16040010	0	Glutamate	0,9	tumor_necrosis_factor-alpha	48,75	Glutamate	tumor necrosis factor-alpha	CHEBI:29987	24835(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Glutamate induces the expression and release of tumor_necrosis_factor-alpha in cultured hypothalamic cells .
25405480	0	Glutamic_Acid	39,52	CD4	14,17	Glutamic Acid	CD4	CHEBI:18237	920	Chemical	Gene	Responses|acl|START_ENTITY Responses|compound|END_ENTITY	Assessment of CD4 + T Cell Responses to Glutamic_Acid Decarboxylase 65 Using DQ8 Tetramers Reveals a Pathogenic Role of GAD65 121-140 and GAD65 250-266 in T1D Development .
15927466	0	Glutamic_acid	0,13	dipeptidyl_peptidase_IV	34,57	Glutamic acid	dipeptidyl peptidase IV	CHEBI:18237	1803	Chemical	Gene	analogues|nsubj|START_ENTITY analogues|nmod|END_ENTITY	Glutamic_acid analogues as potent dipeptidyl_peptidase_IV and 8 inhibitors .
26833123	0	Glutamine	45,54	EPHA2	14,19	Glutamine	EPHA2	D018698	1969	Chemical	Gene	Metabolism|compound|START_ENTITY Metabolism|compound|END_ENTITY	The Ephrin-A1 / EPHA2 Signaling Axis Regulates Glutamine Metabolism in HER2-Positive Breast_Cancer .
24352239	0	Glutamine	0,9	H2A	33,36	Glutamine	H2A	CHEBI:28300	8337	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification .
26797129	0	Glutamine	43,52	HEMK2	29,34	Glutamine	HEMK2	D018698	29104	Chemical	Gene	Methyltransferase|compound|START_ENTITY Methyltransferase|compound|END_ENTITY	Substrate Specificity of the HEMK2 Protein Glutamine Methyltransferase and Identification of Novel Substrates .
24976418	0	Glutamine	0,9	Hsp72	21,26	Glutamine	Hsp72	CHEBI:28300	3303	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	Glutamine suppresses Hsp72 not Hsp90a and is not inducing Th1 , Th2 , or Th17 cytokine responses in human septic PBMCs .
24976418	0	Glutamine	0,9	Hsp90a	31,37	Glutamine	Hsp90a	CHEBI:28300	3324	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	Glutamine suppresses Hsp72 not Hsp90a and is not inducing Th1 , Th2 , or Th17 cytokine responses in human septic PBMCs .
23498057	0	Glutamine	0,9	IL-6	71,75	Glutamine	IL-6	CHEBI:28300	3569	Chemical	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Glutamine and alanine-induced differential expression of intracellular IL-6 , IL-8 , and TNF-a in LPS-stimulated monocytes in human whole-blood .
24106489	0	Glutamine	45,54	Slc38a3	72,79	Glutamine	Slc38a3	CHEBI:28300	10991	Chemical	Gene	SN1|compound|START_ENTITY SN1|appos|END_ENTITY	Protein_Kinase_C Phosphorylates the System N Glutamine Transporter SN1 -LRB- Slc38a3 -RRB- and Regulates Its Membrane Trafficking and Degradation .
24952788	0	Glutamine	0,9	TLR-2	24,29	Glutamine	TLR-2	CHEBI:28300	310553(Tax:10116)	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	Glutamine downregulates TLR-2 and TLR-4 expression and protects intestinal tract in preterm neonatal rats with necrotizing_enterocolitis .
18807160	0	Glutamine	0,9	TNF-alpha	18,27	Glutamine	TNF-alpha	CHEBI:28300	24835(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	Glutamine reduces TNF-alpha by enhancing glutathione synthesis in lipopolysaccharide-stimulated alveolar epithelial cells of rats .
14570901	0	Glutamine	0,9	argininosuccinate_synthetase	21,49	Glutamine	argininosuccinate synthetase	CHEBI:28300	445	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Glutamine stimulates argininosuccinate_synthetase gene expression through cytosolic O-glycosylation of Sp1 in Caco-2 cells .
15365617	0	Glutamine	0,9	glucagon-like_peptide-1	30,53	Glutamine	glucagon-like peptide-1	CHEBI:28300	2641	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|amod|END_ENTITY	Glutamine potently stimulates glucagon-like_peptide-1 secretion from GLUTag cells .
11421603	0	Glutamine	0,9	growth_hormone	45,59	Glutamine	growth hormone	CHEBI:28300	81668(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|effect effect|nmod|END_ENTITY	Glutamine enhances the gut-trophic effect of growth_hormone in rat after massive small bowel resection .
11356807	0	Glutamine	0,9	heat_shock_protein	18,36	Glutamine	heat shock protein	CHEBI:28300	290549(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Glutamine induces heat_shock_protein and protects against endotoxin shock in the rat .
15723751	0	Glutamine	0,9	heat_shock_protein_70	94,115	Glutamine	heat shock protein 70	CHEBI:28300	266759(Tax:10116)	Chemical	Gene	attenuates|amod|START_ENTITY attenuates|dep|role role|nmod|END_ENTITY	Glutamine attenuates endotoxin-induced lung metabolic_dysfunction : potential role of enhanced heat_shock_protein_70 .
17234954	0	Glutamine	0,9	heat_shock_protein_70	70,91	Glutamine	heat shock protein 70	CHEBI:28300	15511(Tax:10090)	Chemical	Gene	protection|nmod:poss|START_ENTITY dependent|nsubj|protection dependent|nmod|expression expression|amod|END_ENTITY	Glutamine 's protection against sepsis and lung_injury is dependent on heat_shock_protein_70 expression .
19776393	0	Glutamine	0,9	heat_shock_protein_70	19,40	Glutamine	heat shock protein 70	CHEBI:28300	15511(Tax:10090)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Glutamine enhances heat_shock_protein_70 expression via increased hexosamine_biosynthetic_pathway activity .
25701159	0	Glutamine	0,9	heat_shock_protein_70	21,42	Glutamine	heat shock protein 70	CHEBI:28300	3308	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|END_ENTITY	Glutamine effects on heat_shock_protein_70 and interleukines 6 and 10 : Randomized trial of glutamine supplementation versus standard parenteral nutrition in critically ill children .
12096924	0	Glutamine	0,9	interleukin-8	20,33	Glutamine	interleukin-8	CHEBI:28300	3576	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|production production|amod|END_ENTITY	Glutamine decreases interleukin-8 and interleukin-6 but not nitric_oxide and prostaglandins_e -LRB- 2 -RRB- production by human gut in-vitro .
21737777	0	Glutamine	0,9	peroxisome_proliferator-activated_receptor-y	20,64	Glutamine	peroxisome proliferator-activated receptor-y	CHEBI:28300	5468	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Glutamine activates peroxisome_proliferator-activated_receptor-y in intestinal epithelial cells via 15-S-HETE and 13-OXO-ODE : a novel mechanism .
12507630	0	Glutamine	0,9	tumor_necrosis_factor-alpha	21,48	Glutamine	tumor necrosis factor-alpha	CHEBI:28300	7124	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|release release|amod|END_ENTITY	Glutamine attenuates tumor_necrosis_factor-alpha release and enhances heat_shock_protein_72 in human peripheral blood mononuclear cells .
26053025	0	Glutathione	72,83	ABCB10	41,47	Glutathione	ABCB10	MESH:D005978	23456	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	ATP Binding and Hydrolysis Properties of ABCB10 and Their Regulation by Glutathione .
25931127	0	Glutathione	29,40	ATF4	102,106	Glutathione	ATF4	MESH:D005978	468	Chemical	Gene	Regulated|nsubjpass|START_ENTITY Regulated|nmod|END_ENTITY	Human CHAC1 Protein Degrades Glutathione and mRNA Induction is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF/CRE Element .
26187465	0	Glutathione	14,25	CD36	56,60	Glutathione	CD36	MESH:D005978	12491(Tax:10090)	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Inhibition of Glutathione Production Induces Macrophage CD36 Expression and Enhances Cellular-oxidized Low Density Lipoprotein -LRB- oxLDL -RRB- Uptake .
9688865	0	Glutathione	0,11	CFTR	28,32	Glutathione	CFTR	MESH:D005978	1080	Chemical	Gene	START_ENTITY|dobj|permeability permeability|nmod|END_ENTITY	Glutathione permeability of CFTR .
12942544	0	Glutathione	0,11	COX-2	36,41	Glutathione	COX-2	MESH:D005978	3283880(Tax:9913)	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|dobj|expression expression|compound|END_ENTITY	Glutathione mediates LPS-stimulated COX-2 expression via early transient p42/44 MAPK activation .
10421891	0	Glutathione	83,94	Extracellular_glutathione_peroxidase	0,36	Glutathione	Extracellular glutathione peroxidase	MESH:D005978	2878	Chemical	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Extracellular_glutathione_peroxidase from the blood-sucking bug , rhodnius prolixus Glutathione peroxidase -LRB- GPX -RRB- activity was measured in several tissues of the blood-sucking bug , Rhodnius prolixus .
25784163	0	Glutathione	94,105	Hgt1p	119,124	Glutathione	Hgt1p	MESH:D005978	853218(Tax:4932)	Chemical	Gene	Transporter|compound|START_ENTITY Scanning|nmod|Transporter Scanning|appos|END_ENTITY	Charged/Polar-Residue Scanning of the Hydrophobic Face of Transmembrane Domain 9 of the Yeast Glutathione Transporter , Hgt1p , Reveals a Conformationally Critical Region for Substrate Transport .
1976305	0	Glutathione	0,11	LHRH	112,116	Glutathione	LHRH	MESH:D005978	25194(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|injection injection|nmod|END_ENTITY	Glutathione and gamma-glutamyl_transpeptidase in the adult female rat brain after intraventricular injection of LHRH and somatostatin .
21358121	0	Glutathione	0,11	Nrf2	83,87	Glutathione	Nrf2	MESH:D005978	83619(Tax:10116)	Chemical	Gene	biosynthesis|amod|START_ENTITY biosynthesis|nmod|activation activation|nmod|END_ENTITY	Glutathione biosynthesis via activation of the nuclear_factor_E2-related_factor_2 -LRB- Nrf2 -RRB- -- antioxidant-response element -LRB- ARE -RRB- pathway is essential for neuroprotective effects of sulforaphane and 6 - -LRB- methylsulfinyl -RRB- _ hexyl_isothiocyanate .
17890327	0	Glutathione	0,11	PAI-1	40,45	Glutathione	PAI-1	MESH:D005978	18787(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Glutathione suppresses TGF-beta-induced PAI-1 expression by inhibiting p38 and JNK MAPK and the binding of AP-1 , SP-1 , and Smad to the PAI-1 promoter .
25904794	0	Glutathione	55,66	Protein_Interacting_with_C-Kinase_1	0,35	Glutathione	Protein Interacting with C-Kinase 1	MESH:D005978	18693(Tax:10090)	Chemical	Gene	Synthesis|compound|START_ENTITY Synthesis|compound|END_ENTITY	Protein_Interacting_with_C-Kinase_1 Deficiency Impairs Glutathione Synthesis and Increases Oxidative Stress via Reduction of Surface Excitatory Amino_Acid Carrier 1 .
25238629	0	Glutathione	159,170	Ras2	120,124	Glutathione	Ras2	MESH:D005978	855625(Tax:4932)	Chemical	Gene	mediated|nmod|START_ENTITY mediated|nmod|END_ENTITY	Protection against cisplatin in calorie-restricted Saccharomyces_cerevisiae is mediated by the nutrient-sensor proteins Ras2 , Tor1 , or Sch9 through its target Glutathione .
11667665	0	Glutathione	87,98	Somatostatin	69,81	Glutathione	Somatostatin	MESH:D005978	6750	Chemical	Gene	Kinetics|nmod|START_ENTITY Kinetics|nmod|END_ENTITY	Kinetics and Equilibria of the Thiol/Disulfide Exchange Reactions of Somatostatin with Glutathione .
16112416	0	Glutathione	0,11	catalase	51,59	Glutathione	catalase	MESH:D005978	847	Chemical	Gene	START_ENTITY|dobj|levels levels|compound|oxidase oxidase|amod|END_ENTITY	Glutathione peroxidase , glutathione-S-transferase , catalase , xanthine oxidase , Cu-Zn_superoxide dismutase activities , total glutathione , nitric_oxide , and malondialdehyde levels in erythrocytes of patients with small cell and non-small_cell_lung_cancer .
3277619	0	Glutathione	0,11	glucose-6-phosphate_dehydrogenase	65,98	Glutathione	glucose-6-phosphate dehydrogenase	MESH:D005978	855480(Tax:4932)	Chemical	Gene	reductase|amod|START_ENTITY mediates|nsubj|reductase mediates|xcomp|END_ENTITY	Glutathione reductase directly mediates the stimulation of yeast glucose-6-phosphate_dehydrogenase by GSSG .
16112416	0	Glutathione	0,11	glutathione-S-transferase	24,49	Glutathione	glutathione-S-transferase	MESH:D005978	373156	Chemical	Gene	START_ENTITY|dobj|levels levels|compound|oxidase oxidase|amod|END_ENTITY	Glutathione peroxidase , glutathione-S-transferase , catalase , xanthine oxidase , Cu-Zn_superoxide dismutase activities , total glutathione , nitric_oxide , and malondialdehyde levels in erythrocytes of patients with small cell and non-small_cell_lung_cancer .
2230538	0	Glutathione	0,11	glutathione_S-transferase	13,38	Glutathione	glutathione S-transferase	MESH:D005978	373156	Chemical	Gene	conjugate|advmod|START_ENTITY conjugate|nsubj|transport transport|amod|END_ENTITY	Glutathione , glutathione_S-transferase , and transmembrane transport of glutathione conjugate in human neutrophil leukocytes .
22532120	0	Glutathione	0,11	glutathione_S-transferase	13,38	Glutathione	glutathione S-transferase	MESH:D005978	373156	Chemical	Gene	stress|advmod|START_ENTITY stress|nsubj|END_ENTITY	Glutathione , glutathione_S-transferase , and glutathione conjugates , complementary markers of oxidative stress in aquatic biota .
7755575	0	Glutathione	0,11	glutathione_S-transferase	59,84	Glutathione	glutathione S-transferase	MESH:D005978	373156	Chemical	Gene	analogues|nsubj|START_ENTITY analogues|nmod|inhibitors inhibitors|nmod|isoenzymes isoenzymes|amod|END_ENTITY	Glutathione analogues as novel inhibitors of rat and human glutathione_S-transferase isoenzymes , as well as of glutathione conjugation in isolated rat hepatocytes and in the rat in vivo .
14637279	0	Glutathione	0,11	glutathione_reductase	24,45	Glutathione	glutathione reductase	MESH:D005978	2936	Chemical	Gene	peroxidase|amod|START_ENTITY peroxidase|appos|activities activities|amod|END_ENTITY	Glutathione peroxidase , glutathione_reductase , Cu-Zn_superoxide dismutase activities , glutathione , nitric_oxide , and malondialdehyde concentrations in serum of patients with chronic_lymphocytic_leukemia .
7806433	0	Glutathione	0,11	interleukin-2	22,35	Glutathione	interleukin-2	MESH:D005978	3558	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|production production|compound|END_ENTITY	Glutathione increases interleukin-2 production in human lymphocytes .
24737944	0	Glutathione	0,11	nrf2	107,111	Glutathione	nrf2	MESH:D005978	4780	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|stress stress|nmod|expression expression|amod|END_ENTITY	Glutathione protects brain endothelial cells from hydrogen_peroxide-induced oxidative stress by increasing nrf2 expression .
15507438	0	Glutathione	0,11	oxidoreductase	32,46	Glutathione	oxidoreductase	MESH:D005978	7296	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	Glutathione directly reduces an oxidoreductase in the endoplasmic reticulum of mammalian cells .
24247155	0	Glutathione	0,11	sodium-dependent_dicarboxylate_transporter	53,95	Glutathione	sodium-dependent dicarboxylate transporter	MESH:D005978	284111	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Glutathione is a low-affinity substrate of the human sodium-dependent_dicarboxylate_transporter .
27011512	0	Glutathione_S	55,68	GSTT1	83,88	Glutathione S	GSTT1	null	2952	Chemical	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Prospective Case-Control Study to Evaluate the Role of Glutathione_S Transferases -LRB- GSTT1 and GSTM1 -RRB- Gene Deletion in Breast_Carcinoma and Its Prognostic Significance .
25858298	0	Gly	54,57	A13	49,52	Gly	A13	MESH:C066286	28888	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|appos|END_ENTITY	Fortuitous description of haemoglobin A2 ' -LSB- 16 -LRB- A13 -RRB- Gly _ > _ Arg -LRB- GGC _ > _ CGC -RRB- -RSB- in a Tunisian family : study of the molecular defect and its origin .
23285694	0	Gly-Gly-His	10,21	IL-6	85,89	Gly-Gly-His	IL-6	MESH:C037026	3569	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of Gly-Gly-His , Gly-His-Lys and their copper complexes on TNF-alpha-dependent IL-6 secretion in normal human dermal fibroblasts .
17020538	0	Gly-Phe-CHN2	98,110	dipeptidyl_peptidase_I	31,53	Gly-Phe-CHN2	dipeptidyl peptidase I	MESH:C089960	1075	Chemical	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	The crystal structure of human dipeptidyl_peptidase_I -LRB- cathepsin_C -RRB- in complex with the inhibitor Gly-Phe-CHN2 .
8219036	0	Gly-Pro-Glu	53,64	IGF-1	11,16	Gly-Pro-Glu	IGF-1	MESH:C062053	24482(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of IGF-1 , truncated IGF-1 and the tripeptide Gly-Pro-Glu on acetylcholine release from parietal cortex of rat brain .
10341844	0	Gly-Pro-Hyp	31,42	Gp_VI	77,82	Gly-Pro-Hyp	Gp VI	MESH:C088188	51206	Chemical	Gene	specific|nsubj|START_ENTITY specific|nmod|END_ENTITY	Collagen-platelet interaction : Gly-Pro-Hyp is uniquely specific for platelet Gp_VI and mediates platelet activation by collagen .
1744103	0	Gly-Pro-Leu-Tyr	21,36	insulin_receptor	92,108	Gly-Pro-Leu-Tyr	insulin receptor	null	3643	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Amino_acid sequences Gly-Pro-Leu-Tyr and Asn-Pro-Glu-Tyr in the submembranous domain of the insulin_receptor are required for normal endocytosis .
26437013	0	Glyburide	0,9	Insulin	13,20	Glyburide	Insulin	MESH:D005905	3630	Chemical	Gene	vs|nsubj|START_ENTITY vs|dobj|END_ENTITY	Glyburide vs Insulin and Adverse Pregnancy Outcomes-Reply .
8123030	0	Glyburide	0,9	insulin	19,26	Glyburide	insulin	MESH:D005905	3630	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	Glyburide enhances insulin gene expression and glucose-induced insulin release in isolated rat islets .
26296158	0	Glyceollin	0,10	MRP2	22,26	Glyceollin	MRP2	MESH:C017343	1244	Chemical	Gene	Effects|compound|START_ENTITY Effects|nmod|END_ENTITY	Glyceollin Effects on MRP2 and BCRP in Caco-2 Cells , and Implications for Metabolic and Transport Interactions .
22847419	0	Glyceraldehyde-3-phosphate	0,26	GAPDH	42,47	Glyceraldehyde-3-phosphate	GAPDH	MESH:D005986	2597	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	Glyceraldehyde-3-phosphate dehydrogenase -LRB- GAPDH -RRB- induces cancer cell senescence by interacting with telomerase RNA component .
21760877	0	Glyceraldehyde_3-Phosphate	99,125	GAPDHS	141,147	Glyceraldehyde 3-Phosphate	GAPDHS	MESH:D005986	26330	Chemical	Gene	Dehydrogenase|compound|START_ENTITY Dehydrogenase|appos|END_ENTITY	Development and Implementation of a High Throughput Screen for the Human Sperm-Specific Isoform of Glyceraldehyde_3-Phosphate Dehydrogenase -LRB- GAPDHS -RRB- .
26024902	0	Glycerol	18,26	Fps1	35,39	Glycerol	Fps1	MESH:D005990	850683(Tax:4932)	Chemical	Gene	Functions|compound|START_ENTITY Functions|compound|END_ENTITY	Rgc2 Regulator of Glycerol Channel Fps1 Functions as Homo - _ and_Hetero-dimers with Rgc1 .
9113273	0	Glycerol	0,8	cytochrome_P-4502E1	49,68	Glycerol	cytochrome P-4502E1	MESH:D005990	1571	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|content content|nmod|END_ENTITY	Glycerol increases content and activity of human cytochrome_P-4502E1 in a transduced HepG2 cell line by protein stabilization .
21536471	0	Glycerol	0,8	glycerol_kinase	39,54	Glycerol	glycerol kinase	MESH:D005990	14933(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Glycerol homeostasis and metabolism in glycerol_kinase carrier mice .
26873514	0	Glycerol_Monolaurate	0,20	Lipase	30,36	Glycerol Monolaurate	Lipase	MESH:C020777	17374477	Chemical	Gene	Production|compound|START_ENTITY Production|compound|END_ENTITY	Glycerol_Monolaurate Inhibits Lipase Production by Clinical Ocular Isolates Without Affecting Bacterial Cell Viability .
17716865	0	Glycerophosphoinositol-4-phosphate	0,34	Vav	120,123	Glycerophosphoinositol-4-phosphate	Vav	MESH:C062528	7409	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|activation activation|nmod|END_ENTITY	Glycerophosphoinositol-4-phosphate enhances SDF-1alpha-stimulated T-cell chemotaxis through PTK-dependent activation of Vav .
11742226	0	Glyceryl_trinitrate	0,19	soluble_guanylyl_cyclase	43,67	Glyceryl trinitrate	soluble guanylyl cyclase	MESH:D005996	25206(Tax:10116)	Chemical	Gene	up-regulates|amod|START_ENTITY END_ENTITY|nsubj|up-regulates	Glyceryl_trinitrate treatment up-regulates soluble_guanylyl_cyclase in rat dura mater .
26722042	0	Glycine	65,72	GLDC	59,63	Glycine	GLDC	D005998	2731	Chemical	Gene	Dehydrogenase|compound|START_ENTITY Silencing|appos|Dehydrogenase Silencing|nmod|END_ENTITY	Epigenetic Silencing of the Putative Tumor Suppressor Gene GLDC -LRB- Glycine Dehydrogenase -RRB- in Gastric_Carcinoma .
11159884	0	Glycine	0,7	GLYT1	74,79	Glycine	GLYT1	CHEBI:57305	6536	Chemical	Gene	supply|amod|START_ENTITY mediated|nsubj|supply mediated|nmod|END_ENTITY	Glycine supply to human enterocytes mediated by high-affinity basolateral GLYT1 .
11259500	0	Glycine	0,7	GLYT1	28,33	Glycine	GLYT1	CHEBI:57305	14664(Tax:10090)	Chemical	Gene	taken|nsubjpass|START_ENTITY taken|nmod|transporters transporters|compound|END_ENTITY	Glycine is taken up through GLYT1 and GLYT2 transporters into mouse spinal cord axon terminals and causes vesicular and carrier-mediated release of its proposed co-transmitter GABA .
15588724	0	Glycine	0,7	GLYT1	25,30	Glycine	GLYT1	CHEBI:57305	14664(Tax:10090)	Chemical	Gene	START_ENTITY|acl|taken taken|nmod|heterotransporters heterotransporters|compound|END_ENTITY	Glycine taken up through GLYT1 and GLYT2 heterotransporters into glutamatergic axon terminals of mouse spinal cord elicits release of glutamate by homotransporter reversal and through anion channels .
20637735	0	Glycine	0,7	GlyT1	21,26	Glycine	GlyT1	CHEBI:57305	14664(Tax:10090)	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Glycine transporter -LRB- GlyT1 -RRB- inhibitors with reduced residence time increase prepulse inhibition without inducing hyperlocomotion in DBA/2 mice .
23194655	0	Glycine	0,7	GlyT1	112,117	Glycine	GlyT1	CHEBI:57305	6536	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|dep|focus focus|nmod|glycine_transporter_1 glycine_transporter_1|appos|END_ENTITY	Glycine reuptake inhibition as a new therapeutic approach in schizophrenia : focus on the glycine_transporter_1 -LRB- GlyT1 -RRB- .
25301276	0	Glycine	0,7	GlyT1	21,26	Glycine	GlyT1	CHEBI:57305	100126661(Tax:8355)	Chemical	Gene	transporters|amod|START_ENTITY transporters|acl:relcl|modulated modulated|nsubjpass|END_ENTITY	Glycine transporters GlyT1 and GlyT2 are differentially modulated by glycogen synthase kinase 3b Inhibitory glycinergic neurotransmission is terminated by the specific glycine transporters GlyT1 and GlyT2 which actively reuptake glycine from the synaptic cleft .
25486018	0	Glycine	84,91	PPARa	16,21	Glycine	PPARa	CHEBI:57305	25747(Tax:10116)	Chemical	Gene	Turnover|nmod|START_ENTITY Turnover|compound|END_ENTITY	Pharmacological PPARa Activation Markedly Alters Plasma Turnover of the Amino_Acids Glycine , Serine and Arginine in the Rat .
15060063	0	Glycine	0,7	SR-BI	56,61	Glycine	SR-BI	CHEBI:57305	949	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Glycine 420 near the C-terminal transmembrane domain of SR-BI is critical for proper delivery and metabolism of high density lipoprotein cholesteryl_ester .
10658629	0	Glycine	0,7	gephyrin	18,26	Glycine	gephyrin	CHEBI:57305	64845(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Glycine receptor -LRB- gephyrin -RRB- immunoreactivity is present on cholinergic neurons in the dorsal vagal complex .
7376793	0	Glycine	0,7	growth_hormone	19,33	Glycine	growth hormone	CHEBI:57305	2688	Chemical	Gene	stimulated|compound|START_ENTITY END_ENTITY|nsubj|stimulated	Glycine stimulated growth_hormone release in man .
9331923	0	Glycine	0,7	neurokinin1_receptor	31,51	Glycine	neurokinin1 receptor	CHEBI:57305	24807(Tax:10116)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Glycine receptor regulation of neurokinin1_receptor function in rat dorsal horn neurones .
17174337	0	Glycochenodeoxycholate	0,22	iNOS	56,60	Glycochenodeoxycholate	iNOS	MESH:D005999	24599(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Glycochenodeoxycholate -LRB- GCDC -RRB- inhibits cytokine induced iNOS expression in rat hepatocytes .
17132480	0	Glycodelin	0,10	vascular_endothelial_growth_factor	36,70	Glycodelin	vascular endothelial growth factor	null	7422	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Glycodelin mediates the increase in vascular_endothelial_growth_factor in response to oxidative stress in the endometrium .
11310976	0	Glycophorin_A	0,13	congenital_dyserythropoietic_anemia_type_I_and_type_II	35,89	Glycophorin A	congenital dyserythropoietic anemia type I and type II	MESH:D006021	146059	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	Glycophorin_A in two patients with congenital_dyserythropoietic_anemia_type_I_and_type_II is partly unglycosylated .
1451177	0	Glycophorin_A	0,13	interleukin-2	29,42	Glycophorin A	interleukin-2	MESH:D006021	3558	Chemical	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Glycophorin_A interacts with interleukin-2 and inhibits interleukin-2-dependent T-lymphocyte proliferation .
24556877	0	Glycopyrronium	67,81	COPD	103,107	Glycopyrronium	COPD	null	260431	Chemical	Gene	START_ENTITY|nmod|treatment treatment|nmod|END_ENTITY	Efficacy and safety of a fixed-dose combination of indacaterol and Glycopyrronium for the treatment of COPD : a systematic review .
10939638	0	Glycosylphosphatidylinositol	0,28	TGF-beta1	83,92	Glycosylphosphatidylinositol	TGF-beta1	MESH:D017261	100008645(Tax:9986)	Chemical	Gene	hydrolysis|nsubj|START_ENTITY hydrolysis|nmod|END_ENTITY	Glycosylphosphatidylinositol -LRB- GPI -RRB- hydrolysis by transforming_growth_factor-beta1 -LRB- TGF-beta1 -RRB- as a potential early step in the inhibition of epithelial cell proliferation .
8283474	0	Glycyl-L-glutamine	0,18	acetylcholinesterase	58,78	Glycyl-L-glutamine	acetylcholinesterase	MESH:C039788	83817(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|forms forms|amod|END_ENTITY	Glycyl-L-glutamine regulates the expression of asymmetric acetylcholinesterase molecular forms in cultured cardiac post-natal myocytes .
20418897	0	Glycyrrhetinic_acid	0,19	ICAM-1	29,35	Glycyrrhetinic acid	ICAM-1	MESH:D006034	3383	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Glycyrrhetinic_acid inhibits ICAM-1 expression via blocking JNK and NF-kappaB pathways in TNF-alpha-activated endothelial cells .
20011054	0	Glycyrrhizic_Acid	11,28	Peroxisome_Proliferator-Activated_Receptor_Gamma	32,80	Glycyrrhizic Acid	Peroxisome Proliferator-Activated Receptor Gamma	MESH:D019695	25664(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of Glycyrrhizic_Acid on Peroxisome_Proliferator-Activated_Receptor_Gamma -LRB- PPARgamma -RRB- , Lipoprotein_Lipase -LRB- LPL -RRB- , Serum Lipid and HOMA-IR in Rats .
24486211	0	Glycyrrhizin	0,12	CYP3A	75,80	Glycyrrhizin	CYP3A	MESH:D019695	170509(Tax:10116)	Chemical	Gene	accelerates|nsubj|START_ENTITY accelerates|nmod|induction induction|nmod|END_ENTITY	Glycyrrhizin accelerates the metabolism of triptolide through induction of CYP3A in rats .
25526376	0	Glycyrrhizin	21,33	HMGB1	64,69	Glycyrrhizin	HMGB1	MESH:D019695	15289(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|Releasing Releasing|compound|END_ENTITY	Inhibition Effect of Glycyrrhizin in Lipopolysaccharide Induced HMGB1 Releasing and Expression from RAW264 .7 Cells .
25541713	0	Glycyrrhizin	0,12	HMGB1	43,48	Glycyrrhizin	HMGB1	MESH:D019695	25459(Tax:10116)	Chemical	Gene	Suppresses|compound|START_ENTITY Suppresses|dep|Expressions Expressions|nmod|END_ENTITY	Glycyrrhizin Suppresses the Expressions of HMGB1 and Relieves the Severity of Traumatic Pancreatitis in Rats .
25812767	0	Glycyrrhizin	0,12	HMGB1	21,26	Glycyrrhizin	HMGB1	MESH:D019695	15289(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|secretion secretion|nummod|END_ENTITY	Glycyrrhizin reduces HMGB1 secretion in lipopolysaccharide-activated RAW 264.7 cells and endotoxemic mice by p38/Nrf2-dependent induction of HO-1 .
26045910	0	Glycyrrhizin	123,135	HMGB1	50,55	Glycyrrhizin	HMGB1	MESH:D019695	3146	Chemical	Gene	Death|compound|START_ENTITY Increase|nmod|Death Increase|nmod|Level Level|nmod|END_ENTITY	Increase in the Level of Proinflammatory Cytokine HMGB1 in Nasal Fluids of Patients With Rhinitis and its Sequestration by Glycyrrhizin Induces Eosinophil Cell Death .
25420924	0	Glycyrrhizin	0,12	high_mobility_group_box-1	27,52	Glycyrrhizin	high mobility group box-1	MESH:D019695	25459(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Glycyrrhizin , inhibitor of high_mobility_group_box-1 , attenuates monocrotaline-induced pulmonary_hypertension and vascular remodeling in rats .
14614603	0	Glycyrrhizin	0,12	interleukin-10	22,36	Glycyrrhizin	interleukin-10	MESH:D019695	16153(Tax:10090)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|amod|END_ENTITY	Glycyrrhizin enhances interleukin-10 production by liver dendritic cells in mice with hepatitis .
8406577	0	Glycyrrhizin	0,12	interleukin-2	63,76	Glycyrrhizin	interleukin-2	MESH:D019695	3558	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Glycyrrhizin as a promoter of the late signal transduction for interleukin-2 production by splenic lymphocytes .
18344608	0	Glycyrrhizin	0,12	interleukin-8	22,35	Glycyrrhizin	interleukin-8	MESH:D019695	3576	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Glycyrrhizin inhibits interleukin-8 production and nuclear factor-kappaB activity in lung epithelial cells , but not through glucocorticoid receptors .
22002176	0	Glyphosate	0,10	acetylcholinesterase	17,37	Glyphosate	acetylcholinesterase	CHEBI:27744	43	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|amod|END_ENTITY	Glyphosate as an acetylcholinesterase inhibitor in Cnesterodon decemmaculatus .
22626647	0	GnIH	75,79	GnRH	47,51	GnIH	GnRH	null	14714(Tax:10090)	Chemical	Gene	pathway|compound|START_ENTITY END_ENTITY|nmod|pathway	Neonatal dexamethasone exposure down-regulates GnRH expression through the GnIH pathway in female mice .
16488906	0	GnRH	81,85	Abl_interactor_2	18,34	GnRH	Abl interactor 2	MESH:D007987	10152	Chemical	Gene	analogue|compound|START_ENTITY END_ENTITY|nmod|analogue	The expression of Abl_interactor_2 in leiomyoma and myometrium and regulation by GnRH analogue and transforming growth factor-beta .
26973595	0	GnRH	69,73	Ankrd_26	21,29	GnRH	Ankrd 26	MESH:D007987	312667(Tax:10116)	Chemical	Gene	Neurons|compound|START_ENTITY Expression|nmod|Neurons Expression|compound|END_ENTITY	Kisspeptin Activates Ankrd_26 Gene Expression in Migrating Embryonic GnRH Neurons .
25925352	0	GnRH	59,63	E-selectin	0,10	GnRH	E-selectin	MESH:D007987	6401	Chemical	Gene	levels|nmod|START_ENTITY levels|amod|END_ENTITY	E-selectin , resistin and reactive oxygen species levels in GnRH - agonist and - antagonist protocols in IVF/ICSI : a prospective cohort study .
11875099	0	GnRH	0,4	ERK1/2	15,21	GnRH	ERK1/2	MESH:D007987	5595;5594	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	GnRH activates ERK1/2 leading to the induction of c-fos and LHbeta protein expression in LbetaT2 cells .
26238084	0	GnRH	50,54	ERK1/2	29,35	GnRH	ERK1/2	MESH:D007987	50689;116590	Chemical	Gene	activation|nmod|START_ENTITY activation|nsubj|Role Role|nmod|END_ENTITY	Role of PI4K and PI3K-AKT in ERK1/2 activation by GnRH in the pituitary gonadotropes .
26835742	0	GnRH	0,4	ERK1/2	69,75	GnRH	ERK1/2	MESH:D007987	50689;116590	Chemical	Gene	Control|compound|START_ENTITY Mediated|nsubj|Control Mediated|nmod|Regulation Regulation|compound|END_ENTITY	GnRH Pulse Frequency Control of Fshb Gene Expression Is Mediated via ERK1/2 Regulation of ICER .
26835742	0	GnRH	0,4	Fshb	32,36	GnRH	Fshb	MESH:D007987	25447(Tax:10116)	Chemical	Gene	Control|compound|START_ENTITY Control|nmod|Expression Expression|compound|END_ENTITY	GnRH Pulse Frequency Control of Fshb Gene Expression Is Mediated via ERK1/2 Regulation of ICER .
20301509	0	GnRH	124,128	Gonadotropin-Releasing_Hormone	9,39	GnRH	Gonadotropin-Releasing Hormone	MESH:D007987	2796	Chemical	Gene	deficiency|appos|START_ENTITY characterized|nsubjpass|deficiency Isolated|ccomp|characterized Isolated|nsubj|END_ENTITY	Isolated Gonadotropin-Releasing_Hormone -LRB- GnRH -RRB- Deficiency DISEASE CHARACTERISTICS : Isolated gonadotropin-releasing_hormone -LRB- GnRH -RRB- deficiency -LRB- IGD -RRB- is characterized by inappropriately low serum concentrations of the gonadotropins LH -LRB- luteinizing hormone -RRB- and FSH -LRB- follicle-stimulating hormone -RRB- in the setting of hypogonadism .
7546241	0	GnRH	32,36	Gonadotropin_releasing_hormone	0,30	GnRH	Gonadotropin releasing hormone	MESH:D007987	2796	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Gonadotropin_releasing_hormone -LRB- GnRH -RRB- agonist induces down-regulation of the CD3 + CD25 + lymphocyte subpopulation in peripheral blood .
14723883	0	GnRH	151,155	Jun	0,3	GnRH	Jun	MESH:D007987	3725	Chemical	Gene	forms|amod|START_ENTITY carried|nmod|forms localization|parataxis|carried localization|nsubj|END_ENTITY	Jun localization in cytosolic and nuclear compartments in brain-pituitary system of the frog , Rana esculenta : an analysis carried out in parallel with GnRH molecular forms during the annual reproductive cycle .
22446101	0	GnRH	0,4	Jun	19,22	GnRH	Jun	MESH:D007987	16476(Tax:10090)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	GnRH regulation of Jun and Atf3 requires calcium , calcineurin , and NFAT .
21409515	0	GnRH	218,222	LH_beta	253,260	GnRH	LH beta	MESH:D007987	25329(Tax:10116)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|transcription transcription|compound|END_ENTITY	GnRH pulse frequency differentially regulates steroidogenic_factor_1 -LRB- SF1 -RRB- , dosage-sensitive_sex_reversal-AHC critical region on the X chromosome gene 1 -LRB- DAX1 -RRB- , and serum_response_factor -LRB- SRF -RRB- : potential mechanism for GnRH pulse frequency regulation of LH_beta transcription in the rat .
10614541	0	GnRH	81,85	Leptin	0,6	GnRH	Leptin	MESH:D007987	3952	Chemical	Gene	therapy|compound|START_ENTITY puberty|nmod|therapy puberty|nsubj|concentrations concentrations|compound|END_ENTITY	Leptin concentrations in precocious puberty or untimely puberty with and without GnRH analogue therapy .
21325051	2	GnRH	227,231	Leptin	211,217	GnRH	leptin	MESH:D007987	16846(Tax:10090)	Chemical	Gene	function|amod|START_ENTITY promotes|dobj|function promotes|nsubj|END_ENTITY	Leptin promotes GnRH function via an indirect action on forebrain neurons .
3131748	0	GnRH	99,103	NPY	64,67	GnRH	NPY	MESH:D007987	100301542(Tax:9986)	Chemical	Gene	release|nmod|START_ENTITY END_ENTITY|nmod|release	Release of hypothalamic neuropeptide Y and effects of exogenous NPY on the release of hypothalamic GnRH and pituitary gonadotropins in intact and ovariectomized does in vitro .
3293982	0	GnRH	171,175	NPY	30,33	GnRH	NPY	MESH:D007987	24604(Tax:10116)	Chemical	Gene	hormone|appos|START_ENTITY releasing|dobj|hormone priming|advcl|releasing participates|advcl|priming participates|nsubj|Evidence Evidence|dep|released released|nsubj|neuropeptide_Y neuropeptide_Y|appos|END_ENTITY	Evidence that neuropeptide_Y -LRB- NPY -RRB- released into the hypophysial-portal circulation participates in priming gonadotropes to the effects of gonadotropin releasing hormone -LRB- GnRH -RRB- .
7735299	7	GnRH	1201,1205	NPY	1194,1197	GnRH	NPY	MESH:D007987	574114(Tax:9544)	Chemical	Gene	release|amod|START_ENTITY examine|nmod|release examine|dobj|effects effects|nmod|infusion infusion|nmod|END_ENTITY	This study utilized the push-pull perfusion -LRB- PPP -RRB- technique to examine the effects of either ime or icv infusion of NPY on GnRH release in OVX monkeys treated with or without both ovarian steroids .
8951106	0	GnRH	51,55	NPY	77,80	GnRH	NPY	MESH:D007987	396464(Tax:9031)	Chemical	Gene	gonadotropin-releasing_hormone|appos|START_ENTITY gonadotropin-releasing_hormone|appos|END_ENTITY	Joint migration of gonadotropin-releasing_hormone -LRB- GnRH -RRB- and neuropeptide_Y -LRB- NPY -RRB- neurons from olfactory placode to central nervous system .
20573725	0	GnRH	24,28	Neurokinin_B	0,12	GnRH	Neurokinin B	MESH:D007987	6866	Chemical	Gene	release|amod|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Neurokinin_B stimulates GnRH release in the male monkey -LRB- Macaca_mulatta -RRB- and is colocalized with kisspeptin in the arcuate nucleus .
23393128	0	GnRH	26,30	Neurokinin_B	0,12	GnRH	Neurokinin B	MESH:D007987	6866	Chemical	Gene	secretion|compound|START_ENTITY acute|dep|secretion causes|xcomp|acute causes|nsubj|END_ENTITY	Neurokinin_B causes acute GnRH secretion and repression of GnRH transcription in GT1-7 GnRH neurons .
23393128	0	GnRH	59,63	Neurokinin_B	0,12	GnRH	Neurokinin B	MESH:D007987	6866	Chemical	Gene	transcription|compound|START_ENTITY secretion|nmod|transcription acute|dep|secretion causes|xcomp|acute causes|nsubj|END_ENTITY	Neurokinin_B causes acute GnRH secretion and repression of GnRH transcription in GT1-7 GnRH neurons .
23393128	0	GnRH	87,91	Neurokinin_B	0,12	GnRH	Neurokinin B	MESH:D007987	6866	Chemical	Gene	neurons|compound|START_ENTITY transcription|nmod|neurons secretion|nmod|transcription acute|dep|secretion causes|xcomp|acute causes|nsubj|END_ENTITY	Neurokinin_B causes acute GnRH secretion and repression of GnRH transcription in GT1-7 GnRH neurons .
19342443	0	GnRH	0,4	PACAP	30,35	GnRH	PACAP	MESH:D007987	24166(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|nmod|END_ENTITY	GnRH stimulates expression of PACAP in the pituitary gonadotropes via both the PKA and PKC signaling systems .
23899713	0	GnRH	119,123	PACAP	52,57	GnRH	PACAP	MESH:D007987	116	Chemical	Gene	expression|appos|START_ENTITY increases|dobj|expression increases|nsubj|polypeptide polypeptide|appos|END_ENTITY	Pituitary adenylate cyclase-activating polypeptide -LRB- PACAP -RRB- increases expression of the gonadotropin-releasing_hormone _ -LRB- GnRH -RRB- _ receptor in GnRH-producing GT1-7 cells overexpressing PACAP_type_I_receptor .
24095645	0	GnRH	16,20	PACAP	0,5	GnRH	PACAP	MESH:D007987	116	Chemical	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	PACAP modulates GnRH signaling in gonadotropes .
23664792	0	GnRH	46,50	ghrelin	6,13	GnRH	ghrelin	MESH:D007987	442996(Tax:9940)	Chemical	Gene	decreases|nmod|START_ENTITY decreases|nsubj|END_ENTITY	Human ghrelin decreases pituitary response to GnRH in superovulated ewes .
10843154	0	GnRH	44,48	gonadotropin-releasing_hormone	12,42	GnRH	gonadotropin-releasing hormone	MESH:D007987	2796	Chemical	Gene	Decrease|appos|START_ENTITY Decrease|nmod|END_ENTITY	Decrease in gonadotropin-releasing_hormone -LRB- GnRH -RRB- pulse frequency with aging in postmenopausal women .
11026571	0	GnRH	119,123	gonadotropin-releasing_hormone	80,110	GnRH	gonadotropin-releasing hormone	MESH:D007987	2796	Chemical	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Molecular cloning , distribution and pharmacological characterization of a novel gonadotropin-releasing_hormone -LRB- -LSB- Trp8 -RSB- GnRH -RRB- in frog brain .
1332845	0	GnRH	78,82	gonadotropin-releasing_hormone	46,76	GnRH	gonadotropin-releasing hormone	MESH:D007987	2796	Chemical	Gene	desensitization|appos|START_ENTITY desensitization|acl|END_ENTITY	Development of gonadotrope desensitization to gonadotropin-releasing_hormone -LRB- GnRH -RRB- and recovery are not coupled to inositol_phosphate production or GnRH_receptor number .
15471890	0	GnRH	122,126	gonadotropin-releasing_hormone	90,120	GnRH	gonadotropin-releasing hormone	MESH:D007987	2796	Chemical	Gene	activity|appos|START_ENTITY activity|nmod|END_ENTITY	The product of X-linked_Kallmann 's _ syndrome gene -LRB- KAL1 -RRB- affects the migratory activity of gonadotropin-releasing_hormone -LRB- GnRH -RRB- - producing neurons .
1693373	0	GnRH	105,109	gonadotropin-releasing_hormone	73,103	GnRH	gonadotropin-releasing hormone	MESH:D007987	2796	Chemical	Gene	stimulation|appos|START_ENTITY stimulation|amod|END_ENTITY	Utility of free_alpha-subunit as an alternative neuroendocrine marker of gonadotropin-releasing_hormone -LRB- GnRH -RRB- stimulation of the gonadotroph in the human : evidence from normal and GnRH-deficient men .
18249372	0	GnRH	122,126	gonadotropin-releasing_hormone	90,120	GnRH	gonadotropin-releasing hormone	MESH:D007987	2796	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Follicular fluid anti-M llerian hormone and inhibin_B concentrations : comparison between gonadotropin-releasing_hormone -LRB- GnRH -RRB- agonist and GnRH antagonist cycles .
2150203	0	GnRH	57,61	gonadotropin-releasing_hormone	25,55	GnRH	gonadotropin-releasing hormone	MESH:D007987	2796	Chemical	Gene	analogue|appos|START_ENTITY analogue|amod|END_ENTITY	Ovarian stimulation with gonadotropin-releasing_hormone -LRB- GnRH -RRB- analogue improves the in vitro fertilization -LRB- IVF -RRB- pregnancy rate with both transvaginal and laparoscopic oocyte recovery .
24597289	0	GnRH	131,135	gonadotropin-releasing_hormone	27,57	GnRH	gonadotropin-releasing hormone	MESH:D007987	2796	Chemical	Gene	maturation|nmod|START_ENTITY gonadotropin|nmod|maturation agonist|nmod|gonadotropin agonist|amod|END_ENTITY	Combined administration of gonadotropin-releasing_hormone agonist with human chorionic gonadotropin for final oocyte maturation in GnRH antagonist cycles for in_vitro_fertilization .
7799311	0	GnRH	114,118	growth_hormone	66,80	GnRH	growth hormone	MESH:D007987	2688	Chemical	Gene	stimulation|nmod|START_ENTITY stimulation|amod|END_ENTITY	Plasma concentrations of FSH , LH , thyroid-stimulating hormone and growth_hormone after exogenous stimulation with GnRH , TRH and GHRH in Booroola ewes that are homozygous carriers or non-carriers of the FecB gene .
10090130	0	GnRH	78,82	leptin	6,12	GnRH	leptin	MESH:D007987	3952	Chemical	Gene	START_ENTITY|nsubj|levels levels|compound|END_ENTITY	Serum leptin levels in males with delayed_puberty during short-term pulsatile GnRH administration .
15132726	0	GnRH	52,56	leptin	18,24	GnRH	leptin	MESH:D007987	3952	Chemical	Gene	administration|amod|START_ENTITY Increase|nmod|administration Increase|nmod|END_ENTITY	Increase of serum leptin after short-term pulsatile GnRH administration in children with delayed puberty .
9662716	0	GnRH	13,17	leptin	32,38	GnRH	leptin	MESH:D007987	25608(Tax:10116)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Evidence for GnRH regulation by leptin : leptin administration prevents reduced pulsatile LH secretion during fasting .
9662716	0	GnRH	13,17	leptin	40,46	GnRH	leptin	MESH:D007987	25608(Tax:10116)	Chemical	Gene	regulation|amod|START_ENTITY regulation|dep|administration administration|compound|END_ENTITY	Evidence for GnRH regulation by leptin : leptin administration prevents reduced pulsatile LH secretion during fasting .
22822163	0	GnRH	43,47	progesterone_receptor_membrane_component_1	70,112	GnRH	progesterone receptor membrane component 1	MESH:D007987	53328(Tax:10090)	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Progesterone directly and rapidly inhibits GnRH neuronal activity via progesterone_receptor_membrane_component_1 .
16787696	0	GnRH-Ag	75,82	gonadotropin-releasing_hormone	34,64	GnRH-Ag	gonadotropin-releasing hormone	null	2796	Chemical	Gene	agonists|appos|START_ENTITY agonists|amod|END_ENTITY	A brief review of the addition of gonadotropin-releasing_hormone agonists -LRB- GnRH-Ag -RRB- to growth_hormone -LRB- GH -RRB- treatment of children with idiopathic growth_hormone deficiency : Previously published studies from America .
22512052	0	GnRHa	10,15	VEGF	44,48	GnRHa	VEGF	CHEBI:63533	7422	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of GnRHa on apoptosis and release of VEGF in endometrial cell cultures from patients with adenomyosis .
19304415	0	GnRHa	154,159	gonadotropin-releasing_hormone	114,144	GnRHa	gonadotropin-releasing hormone	CHEBI:63533	2796	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Proliferation and apoptosis of male germ cells in captive Atlantic bluefin tuna -LRB- Thunnus thynnus L. -RRB- treated with gonadotropin-releasing_hormone agonist -LRB- GnRHa -RRB- .
23077235	0	GnRHa	99,104	gonadotropin-releasing_hormone	59,89	GnRHa	gonadotropin-releasing hormone	CHEBI:63533	2796	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Predicting successful induction of oocyte maturation after gonadotropin-releasing_hormone agonist -LRB- GnRHa -RRB- trigger .
24854484	0	GnRHa	80,85	gonadotropin-releasing_hormone	40,70	GnRHa	gonadotropin-releasing hormone	CHEBI:63533	2796	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Triggering final oocyte maturation with gonadotropin-releasing_hormone agonist -LRB- GnRHa -RRB- versus human chorionic_gonadotropin _ -LRB- hCG -RRB- in breast_cancer patients undergoing fertility preservation : an extended experience .
1548045	0	GnRHa	181,186	gonadotropin_releasing_hormone	141,171	GnRHa	gonadotropin releasing hormone	CHEBI:63533	2796	Chemical	Gene	predictive|appos|START_ENTITY predictive|nmod|outcome outcome|dep|effect effect|nmod|agonist agonist|amod|END_ENTITY	Embryo associated immunosuppressor factor -LRB- s -RRB- secreted by preembryo and serum estradiol levels are predictive of pregnancy outcome : effect of gonadotropin_releasing_hormone agonist -LRB- GnRHa -RRB- treatment of patients undergoing in vitro fertilization and embryo transfer -LRB- IVF-ET -RRB- .
2114421	0	GnRHa	147,152	gonadotropin_releasing_hormone	107,137	GnRHa	gonadotropin releasing hormone	CHEBI:63533	2796	Chemical	Gene	effect|appos|START_ENTITY effect|nmod|agonist agonist|amod|END_ENTITY	Immunosuppressive activity in human embryo growth media is associated with successful pregnancy : effect of gonadotropin_releasing_hormone agonist -LRB- GnRHa -RRB- treatment of patients undergoing in vitro fertilization and embryo transfer -LRB- IVF-ET -RRB- .
2127603	0	GnRHa	51,56	gonadotropin_releasing_hormone	11,41	GnRHa	gonadotropin releasing hormone	CHEBI:63533	2796	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	The use of gonadotropin_releasing_hormone agonist -LRB- GnRHa -RRB- in good responders undergoing repeat in vitro fertilization/embryo transfer -LRB- IVF/ET -RRB- .
25322976	0	GnRHa	132,137	gonadotropin_releasing_hormone	92,122	GnRHa	gonadotropin releasing hormone	CHEBI:63533	2796	Chemical	Gene	analogs|appos|START_ENTITY analogs|amod|END_ENTITY	Prevention of Early Menopause Study -LRB- POEMS -RRB- : is it possible to preserve ovarian function by gonadotropin_releasing_hormone analogs -LRB- GnRHa -RRB- ?
12723623	0	Gnetol	0,6	tyrosinase	19,29	Gnetol	tyrosinase	MESH:C476734	22173(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|compound|END_ENTITY	Gnetol as a potent tyrosinase inhibitor from genus Gnetum .
15313909	0	Go6976	38,44	Protein_kinase_C_alpha	0,22	Go6976	Protein kinase C alpha	MESH:C081021	5578	Chemical	Gene	promotes|nsubj|START_ENTITY END_ENTITY|parataxis|promotes	Protein_kinase_C_alpha / beta inhibitor Go6976 promotes formation of cell junctions and inhibits invasion of urinary_bladder_carcinoma cells .
20504936	0	Golgicide_A	53,64	GBF1	37,41	Golgicide A	GBF1	MESH:C539165	8729	Chemical	Gene	inhibitors|dobj|START_ENTITY inhibitors|nsubj|effects effects|nmod|END_ENTITY	Differential effects of the putative GBF1 inhibitors Golgicide_A and AG1478 on enterovirus replication .
24749675	0	Gomisin_A	0,9	iNOS	50,54	Gomisin A	iNOS	MESH:C033585	18126(Tax:10090)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|nmod|END_ENTITY	Gomisin_A decreases the LPS-induced expression of iNOS and COX-2 and activation of RIP2/NF-kB in mouse peritoneal macrophages .
25677216	0	Gonadotropin-Releasing_Hormone	42,72	Neurokinin_B	14,26	Gonadotropin-Releasing Hormone	Neurokinin B	MESH:D007987	443213(Tax:9940)	Chemical	Gene	Secretion|compound|START_ENTITY Secretion|compound|END_ENTITY	Evidence that Neurokinin_B Controls Basal Gonadotropin-Releasing_Hormone Secretion but Is Not Critical for Estrogen-Positive Feedback in Sheep .
23767409	0	Goniothalamin	0,13	caspase-3	82,91	Goniothalamin	caspase-3	MESH:C103280	836	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|amod|END_ENTITY	Goniothalamin selectively induces apoptosis on human hepatoblastoma cells through caspase-3 activation .
20633548	0	Gossypol	0,8	Bcl-2	37,42	Gossypol	Bcl-2	MESH:D006072	596	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Gossypol inhibits phosphorylation of Bcl-2 in human leukemia HL-60 cells .
25231749	0	Gossypol	0,8	Mcl-1	104,109	Gossypol	Mcl-1	MESH:D006072	4170	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|inhibition inhibition|nmod|END_ENTITY	Gossypol induces apoptosis in multiple myeloma cells by inhibition of interleukin-6 signaling and Bcl-2 / Mcl-1 pathway .
18314260	0	Gossypol	0,8	NF-kappaB	20,29	Gossypol	NF-kappaB	MESH:D006072	4790	Chemical	Gene	suppresses|amod|START_ENTITY END_ENTITY|nsubj|suppresses	Gossypol suppresses NF-kappaB activity and NF-kappaB-related gene expression in human leukemia U937 cells .
24778183	0	Gossypol	0,8	NOXA	68,72	Gossypol	NOXA	MESH:D006072	5366	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Gossypol increases expression of the pro-apoptotic BH3-only protein NOXA through a novel mechanism involving phospholipase_A2 , cytoplasmic calcium , and endoplasmic reticulum stress .
6416323	0	Gossypol	0,8	acrosin	23,30	Gossypol	acrosin	MESH:D006072	49	Chemical	Gene	START_ENTITY|dobj|inhibition inhibition|nmod|END_ENTITY	Gossypol inhibition of acrosin and proacrosin , and oocyte penetration by human spermatozoa .
9218727	0	Gossypol	0,8	cyclin_D1	32,41	Gossypol	cyclin D1	MESH:D006072	595	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Gossypol inhibition of mitosis , cyclin_D1 and Rb protein in human mammary_cancer cells and cyclin-D1 transfected human fibrosarcoma cells .
21223991	0	Gossypol	0,8	intercellular_adhesion_molecule-1	51,84	Gossypol	intercellular adhesion molecule-1	MESH:D006072	3383	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|amod|END_ENTITY	Gossypol decreases tumor_necrosis_factor-a-induced intercellular_adhesion_molecule-1 expression via suppression of NF-kB activity .
20124455	0	Gossypol	0,8	p53	41,44	Gossypol	p53	MESH:D006072	7157	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|activating activating|dobj|END_ENTITY	Gossypol induces apoptosis by activating p53 in prostate_cancer cells and prostate_tumor-initiating cells .
26253866	0	Graphene_Oxides	59,74	CO2	4,7	Graphene Oxides	CO2	null	717	Chemical	Gene	Capacity|nmod|START_ENTITY Capacity|compound|END_ENTITY	The CO2 Storage Capacity of the Intercalated Diaminoalkane Graphene_Oxides : A Combination of Experimental and Simulation Studies .
23734789	0	Graphene_oxide	0,14	toll-like_receptor_4	23,43	Graphene oxide	toll-like receptor 4	null	7099	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Graphene_oxide induces toll-like_receptor_4 -LRB- TLR4 -RRB- - dependent necrosis in macrophages .
24591193	0	Grassypeptolides	0,16	dipeptidyl_peptidase_8	42,64	Grassypeptolides	dipeptidyl peptidase 8	null	54878	Chemical	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Grassypeptolides as natural inhibitors of dipeptidyl_peptidase_8 and T-cell activation .
19715320	0	Grassystatins_A-C	0,17	cathepsin_E	52,63	Grassystatins A-C	cathepsin E	null	1510	Chemical	Gene	inhibitors|advcl|START_ENTITY inhibitors|nsubj|END_ENTITY	Grassystatins_A-C from marine cyanobacteria , potent cathepsin_E inhibitors that reduce antigen presentation .
26805806	0	Graveoline	0,10	Acetylcholinesterase	40,60	Graveoline	Acetylcholinesterase	MESH:C487585	43	Chemical	Gene	Activity|compound|START_ENTITY Activity|compound|END_ENTITY	Graveoline Analogs Exhibiting Selective Acetylcholinesterase Inhibitory Activity as Potential Lead Compounds for the Treatment of Alzheimer 's _ Disease .
10670836	0	Grepafloxacin	0,13	interleukin-8	59,72	Grepafloxacin	interleukin-8	MESH:C075375	3576	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Grepafloxacin inhibits tumor_necrosis_factor-alpha-induced interleukin-8 expression in human airway epithelial cells .
20943371	0	Grifolin	0,8	DAPK1	92,97	Grifolin	DAPK1	MESH:C058858	1612	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	Grifolin , a potent antitumour natural product upregulates death-associated_protein_kinase_1 DAPK1 via p53 in nasopharyngeal_carcinoma cells .
26516701	0	Grifolin	0,8	ERK1/2	26,32	Grifolin	ERK1/2	MESH:C058858	26417;26413	Chemical	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Grifolin directly targets ERK1/2 to epigenetically suppress cancer cell metastasis .
12127591	0	Guaianolides	0,12	NF-kappaB	69,78	Guaianolides	NF-kappaB	null	4790	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|END_ENTITY	Guaianolides from Viguiera gardneri inhibit the transcription factor NF-kappaB .
11375656	0	Guanidine_hydrochloride	0,23	Hsp104	33,39	Guanidine hydrochloride	Hsp104	MESH:D019791	850633(Tax:4932)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Guanidine_hydrochloride inhibits Hsp104 activity in vivo : a possible explanation for its effect in curing yeast prions .
18437545	0	Guanidinoacetate	0,16	acetylcholinesterase	42,62	Guanidinoacetate	acetylcholinesterase	CHEBI:24438	83817(Tax:10116)	Chemical	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	Guanidinoacetate administration increases acetylcholinesterase activity in striatum of rats and impairs retention of an inhibitory avoidance task .
25750125	0	Guanine	4,11	Asef2	45,50	Guanine	Asef2	MESH:D006147	221178	Chemical	Gene	Factor|compound|START_ENTITY END_ENTITY|nsubj|Factor	The Guanine Nucleotide Exchange Factor -LRB- GEF -RRB- Asef2 Promotes Dendritic Spine Formation via Rac Activation and Spinophilin-Dependent Targeting .
26542736	0	Guanine_nucleotide	0,18	Cdc42	52,57	Guanine nucleotide	Cdc42	CHEBI:61292	998	Chemical	Gene	change|amod|START_ENTITY change|nmod|END_ENTITY	Guanine_nucleotide induced conformational change of Cdc42 revealed by hydrogen/deuterium exchange mass spectrometry .
6757248	0	Guanine_nucleotide	0,18	cyc	33,36	Guanine nucleotide	cyc	CHEBI:61292	110998(Tax:10090)	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Guanine_nucleotide inhibition of cyc - S49 mouse_lymphoma cell membrane adenylyl cyclase .
2110451	0	Guanine_nucleotide	0,18	rap1	41,45	Guanine nucleotide	rap1	CHEBI:61292	5906	Chemical	Gene	properties|amod|START_ENTITY properties|nmod|END_ENTITY	Guanine_nucleotide binding properties of rap1 purified from human neutrophils .
17202332	0	Guanosine	0,9	CD40	19,23	Guanosine	CD40	MESH:D006151	21939(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Guanosine inhibits CD40 receptor expression and function induced by cytokines and beta amyloid in mouse microglia cells .
25596300	0	Guanosine	12,21	CD40	31,35	Guanosine	CD40	MESH:D006151	21939(Tax:10090)	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Retraction : Guanosine Inhibits CD40 Receptor Expression and Function Induced by Cytokines and b Amyloid in Mouse Microglia Cells .
7830071	0	Guanosine_triphosphate	0,22	microtubule-associated_protein_tau	96,130	Guanosine triphosphate	microtubule-associated protein tau	MESH:D006160	4137	Chemical	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	Guanosine_triphosphate binding to beta-subunit of tubulin in Alzheimer 's _ disease brain : role of microtubule-associated_protein_tau .
19000789	0	Guggulsterone	0,13	IRF3	64,68	Guggulsterone	IRF3	MESH:C023617	3661	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|activation activation|nmod|END_ENTITY	Guggulsterone suppresses the activation of transcription factor IRF3 induced by TLR3 or TLR4 agonists .
15322087	0	Guggulsterone	0,13	NF-kappaB	23,32	Guggulsterone	NF-kappaB	MESH:C023617	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	Guggulsterone inhibits NF-kappaB and IkappaBalpha kinase activation , suppresses expression of anti-apoptotic gene products , and enhances apoptosis .
22095074	0	Guggulsterone	0,13	Nrf2	72,76	Guggulsterone	Nrf2	MESH:C023617	4780	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Guggulsterone induces heme_oxygenase-1 expression through activation of Nrf2 in human mammary epithelial cells : PTEN as a putative target .
18519703	0	Guggulsterone	0,13	SHP-1	155,160	Guggulsterone	SHP-1	MESH:C023617	5777	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|induction induction|nmod|END_ENTITY	Guggulsterone , a farnesoid X receptor antagonist , inhibits constitutive and inducible STAT3 activation through induction of a protein tyrosine phosphatase SHP-1 .
18519703	0	Guggulsterone	0,13	STAT3	86,91	Guggulsterone	STAT3	MESH:C023617	6774	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|compound|END_ENTITY	Guggulsterone , a farnesoid X receptor antagonist , inhibits constitutive and inducible STAT3 activation through induction of a protein tyrosine phosphatase SHP-1 .
19020709	0	Guggulsterone	0,13	STAT3	48,53	Guggulsterone	STAT3	MESH:C023617	6774	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|blocking blocking|dobj|expression expression|compound|END_ENTITY	Guggulsterone inhibits angiogenesis by blocking STAT3 and VEGF expression in colon_cancer cells .
20651339	0	Guggulsterone	0,13	caudal-related_homeobox_2	60,85	Guggulsterone	caudal-related homeobox 2	MESH:C023617	1045	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Guggulsterone suppresses bile_acid-induced and constitutive caudal-related_homeobox_2 expression in gut-derived adenocarcinoma cells .
12525500	0	Guggulsterone	0,13	farnesoid_X_receptor	19,39	Guggulsterone	farnesoid X receptor	MESH:C023617	9971	Chemical	Gene	antagonist|nsubj|START_ENTITY antagonist|compound|END_ENTITY	Guggulsterone is a farnesoid_X_receptor antagonist in coactivator association assays but acts to enhance transcription of bile_salt export pump .
22095074	0	Guggulsterone	0,13	heme_oxygenase-1	22,38	Guggulsterone	heme oxygenase-1	MESH:C023617	3162	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Guggulsterone induces heme_oxygenase-1 expression through activation of Nrf2 in human mammary epithelial cells : PTEN as a putative target .
21500777	0	Gusanlungionosides_A-D	0,22	tyrosinase	34,44	Gusanlungionosides A-D	tyrosinase	null	7299	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Gusanlungionosides_A-D , potential tyrosinase inhibitors from Arcangelisia gusanlung .
19681589	0	Guttiferones_O	0,14	MAPKAPK-2	46,55	Guttiferones O	MAPKAPK-2	null	9261	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Guttiferones_O and P , prenylated benzophenone MAPKAPK-2 inhibitors from Garcinia solomonensis .
20831919	0	Gymnasterkoreayne_F	0,19	NFATc1	65,71	Gymnasterkoreayne F	NFATc1	MESH:C556221	4772	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Gymnasterkoreayne_F inhibits osteoclast formation by suppressing NFATc1 and DC-STAMP expression .
24491353	0	Gymnopilins	0,11	nicotinic_acetylcholine_receptor	65,97	Gymnopilins	nicotinic acetylcholine receptor	null	170945(Tax:10116)	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|END_ENTITY	Gymnopilins , a product of a hallucinogenic mushroom , inhibit the nicotinic_acetylcholine_receptor .
17434475	0	Gypenoside_XLIX	0,15	PPAR-alpha	39,49	Gypenoside XLIX	PPAR-alpha	MESH:C517623	5465	Chemical	Gene	START_ENTITY|appos|activator activator|amod|END_ENTITY	Gypenoside_XLIX , a naturally occurring PPAR-alpha activator , inhibits cytokine-induced vascular_cell_adhesion_molecule-1 expression and activity in human endothelial cells .
17434475	0	Gypenoside_XLIX	0,15	vascular_cell_adhesion_molecule-1	87,120	Gypenoside XLIX	vascular cell adhesion molecule-1	MESH:C517623	7412	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Gypenoside_XLIX , a naturally occurring PPAR-alpha activator , inhibits cytokine-induced vascular_cell_adhesion_molecule-1 expression and activity in human endothelial cells .
20193962	0	H	78,79	Bax_inhibitor-1	110,125	H	Bax inhibitor-1	null	7009	Chemical	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Cardiolipin , phosphatidylserine , and BH4 domain of Bcl-2 family regulate Ca2 + / H + antiporter activity of human Bax_inhibitor-1 .
20633955	0	H	34,35	CAX1	48,52	H	CAX1	null	818395(Tax:3702)	Chemical	Gene	variant|compound|START_ENTITY variant|compound|END_ENTITY	Expression of an Arabidopsis Ca2 + / H + antiporter CAX1 variant in petunia enhances cadmium tolerance and accumulation .
17228902	0	H	49,50	HCN	68,71	H	HCN	null	378938	Chemical	Gene	study|dep|START_ENTITY study|nmod|END_ENTITY	Computational study of the reactions of SiH3X -LRB- X = H , Cl , Br , I -RRB- with HCN .
21469095	0	H	10,11	IL-6	56,60	H	IL-6	null	16193(Tax:10090)	Chemical	Gene	activation|compound|START_ENTITY enhances|nsubj|activation enhances|dobj|production production|compound|END_ENTITY	Histamine H receptor activation enhances LPS-induced IL-6 production in mast cells via ERK and PI3K activation .
21378324	0	H	29,30	NHE	42,45	H	NHE	null	285335	Chemical	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Oxidative stress reduces Na + / H + exchange -LRB- NHE -RRB- activity in a biliary_epithelial_cancer cell line -LRB- Mz-Cha-1 -RRB- .
14669395	0	H	60,61	NHE-1	64,69	H	NHE-1	null	6548	Chemical	Gene	exchanger|compound|START_ENTITY exchanger|appos|END_ENTITY	-LSB- Morphologic parameters of blood platelets and activity NA + / H + -LRB- NHE-1 -RRB- exchanger in normal pregnancy and pregnancy complicated with preeclampsia -RSB- .
11417219	0	H	23,24	NHE-3	45,50	H	NHE-3	null	24784(Tax:10116)	Chemical	Gene	isoform|compound|START_ENTITY isoform|appos|END_ENTITY	An apical membrane Na + / H + exchanger isoform , NHE-3 , is present in the rat epididymal epithelium .
14608410	0	H	16,17	NHE1	30,34	H	NHE1	null	24782(Tax:10116)	Chemical	Gene	exchanger|compound|START_ENTITY exchanger|appos|END_ENTITY	Role of the Na + - H + _ exchanger -LRB- NHE1 -RRB- in heart muscle function during transient acidosis .
18321853	0	H	130,131	NHE1	143,147	H	NHE1	null	24782(Tax:10116)	Chemical	Gene	isoform|compound|START_ENTITY isoform|compound|END_ENTITY	Calcineurin B homologous protein 3 promotes the biosynthetic maturation , cell surface stability , and optimal transport of the Na + / H + exchanger NHE1 isoform .
26304834	0	H	50,51	NHE1	64,68	H	NHE1	D006859	6548	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	Physiological Functions and Regulation of the Na + / H + _ Exchanger -LSB- NHE1 -RSB- in Renal Tubule Epithelial Cells .
12205089	0	H	71,72	NHE5	84,88	H	NHE5	null	192215(Tax:10116)	Chemical	Gene	isoform|compound|START_ENTITY isoform|compound|END_ENTITY	Clathrin-mediated endocytosis and recycling of the neuron-specific Na + / H + exchanger NHE5 isoform .
21296876	0	H	72,73	NHE5	85,89	H	NHE5	null	6553	Chemical	Gene	isoform|compound|START_ENTITY isoform|compound|END_ENTITY	CK2 phosphorylation of an acidic Ser/Thr di-isoleucine motif in the Na + / H + exchanger NHE5 isoform promotes association with beta-arrestin2 and endocytosis .
19276089	0	H	92,93	Secretory_Carrier_Membrane_Protein_2	0,36	H	Secretory Carrier Membrane Protein 2	null	10066	Chemical	Gene	Targeting|nmod|START_ENTITY Targeting|compound|END_ENTITY	Secretory_Carrier_Membrane_Protein_2 Regulates Cell-surface Targeting of Brain-enriched Na + / H + Exchanger NHE5 .
26867566	0	H	16,17	Stat3	99,104	H	Stat3	D006859	20848(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|suppression suppression|nmod|END_ENTITY	Deletion of Na + / H + exchanger regulatory factor 2 represses colon_cancer progress by suppression of Stat3 and CD24 .
22528205	0	H	54,55	bradykinin	31,41	H	bradykinin	null	3827	Chemical	Gene	+|compound|START_ENTITY +|amod|END_ENTITY	Conformational distribution of bradykinin -LSB- bk + 2 H -RSB- 2 + revealed by cold ion spectroscopy coupled with FAIMS .
8892355	0	H	16,17	cyclooxygenase-2	30,46	H	cyclooxygenase-2	null	5743	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Prostaglandin_G / H synthase-2 -LRB- cyclooxygenase-2 -RRB- mRNA expression is decreased in Alzheimer 's _ disease .
10841183	0	H	105,106	interleukin-1	132,145	H	interleukin-1	null	111343(Tax:10090)	Chemical	Gene	synthase|nsubj|START_ENTITY synthase|nmod|END_ENTITY	Involvement of CCAAT_enhancer_binding_protein transcription factors in the regulation of prostaglandin_G / H synthase 2 expression by interleukin-1 in osteoblastic MC3T3-E1 cells .
9661070	0	H	30,31	interleukin-1	57,70	H	interleukin-1	null	3552	Chemical	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Regulation of prostaglandin_G / H synthase-2 expression by interleukin-1 in human osteoblast-like cells .
18559527	0	H	23,24	multidrug_resistance_protein_4	93,123	H	multidrug resistance protein 4	null	10257	Chemical	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Down-regulation of Na + / H + exchanger regulatory factor 1 increases expression and function of multidrug_resistance_protein_4 .
10090570	0	H	25,26	proton-pump	36,47	H	proton-pump	null	24216(Tax:10116)	Chemical	Gene	ATPase|compound|START_ENTITY ATPase|appos|END_ENTITY	Postnatal development of H + ATPase -LRB- proton-pump -RRB- - rich cells in rat epididymis .
7536192	0	H	39,40	stem_cell_factor	55,71	H	stem cell factor	null	17311(Tax:10090)	Chemical	Gene	synthase|nsubj|START_ENTITY synthase|nmod|END_ENTITY	Selective induction of prostaglandin_G / H synthase I by stem_cell_factor and dexamethasone in mast cells .
6140568	0	H-142	40,45	renin	60,65	H-142	renin	MESH:C039583	5972	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Reduction of blood pressure in man with H-142 , a potent new renin inhibitor .
11149024	0	H-7	28,31	hepatoma-derived_growth_factor	66,96	H-7	hepatoma-derived growth factor	MESH:D019307	3068	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|activity activity|nmod|END_ENTITY	Protein kinase C inhibitor , H-7 suppresses the growth activity of hepatoma-derived_growth_factor .
7040240	0	H-77	0,4	renin	19,24	H-77	renin	MESH:C034503	403838(Tax:9615)	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	H-77 : a potent new renin inhibitor .
8287370	0	H-87	38,42	MDR1	14,18	H-87	MDR1	MESH:C063509	18669(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Inhibition of MDR1 gene expression by H-87 , a selective inhibitor of cAMP-dependent protein kinase .
11833426	8	H-89	1436,1440	PKA	1589,1592	H-89	PKA	MESH:C063509	25636(Tax:10116)	Chemical	Gene	VSMCs|nmod|START_ENTITY Pre-treatment|nmod|VSMCs abolished|nsubj|Pre-treatment abolished|advcl|implying implying|ccomp|mediated mediated|nmod|END_ENTITY	Pre-treatment of VSMCs with 100 nmol/L H-89 , a protein_kinase_A -LRB- PKA -RRB- inhibitor , abolished the desensitization of CGRP-acting receptor , implying that this desensitization was mediated through PKA .
9458736	0	H-89	15,19	PKA	0,3	H-89	PKA	MESH:C063509	25636(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	PKA inhibitor , H-89 , affects the intracellular transit of regulated secretory proteins in rat lacrimal glands .
125273	0	H-meromyosin	84,96	ATPase	61,67	H-meromyosin	ATPase	null	1769	Chemical	Gene	treatment|nmod|START_ENTITY END_ENTITY|nmod|treatment	Desensitization of substrate inhibition of acto-H-meromyosin ATPase by treatment of H-meromyosin with rho-chloromercuribenzoate .
11819564	0	H-rasp21	34,42	p53	29,32	H-rasp21	p53	null	7157	Chemical	Gene	protein|dep|START_ENTITY protein|compound|END_ENTITY	Immunohistochemical study on p53 , H-rasp21 , c-erbB-2 protein and PCNA expression in HCC tissues of Han and minority ethnic patients .
23427531	0	H2	38,40	NaK	80,83	H2	NaK	null	29110	Chemical	Gene	START_ENTITY|nmod|transfer transfer|nmod|END_ENTITY	-LSB- Rovibrational state distributions of H2 in collisional energy transfer between NaK -LRB- 6 -LRB- 1 -RRB- sigma -LRB- + -RRB- -RRB- and H2 -RSB- .
21544615	0	H2	0,2	lectin-like_oxidized_LDL_receptor-1	26,61	H2	lectin-like oxidized LDL receptor-1	null	108078(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	H2 inhibits TNF-a-induced lectin-like_oxidized_LDL_receptor-1 expression by inhibiting nuclear factor kB activation in endothelial cells .
1358235	0	H2-blockade	14,25	gastrin	36,43	H2-blockade	gastrin	null	2520	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|concentration concentration|compound|END_ENTITY	The effect of H2-blockade on plasma gastrin concentration in patients with an achlorhydric_stomach .
15970663	0	H2B	0,3	Ser10	5,10	H2B	Ser10	null	3190220(Tax:176280)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|appos|END_ENTITY	H2B -LRB- Ser10 -RRB- phosphorylation is induced during apoptosis and meiosis in S. _ cerevisiae .
16239733	0	H2O	100,103	gammaE-crystallin	79,96	H2O	gammaE-crystallin	CHEBI:33813	24279(Tax:10116)	Chemical	Gene	comparison|nmod|START_ENTITY comparison|nmod|END_ENTITY	A comparison of refined X-ray structures of hydrogenated and perdeuterated rat gammaE-crystallin in H2O and D2O .
5274441	0	H2O	58,61	myoglobin	45,54	H2O	myoglobin	CHEBI:33813	100054434(Tax:9796)	Chemical	Gene	studies|nmod|START_ENTITY studies|nmod|END_ENTITY	Proton nuclear magnetic resonance studies of myoglobin in H2O .
24934860	2	H2O2	320,324	ATM	380,383	H2O2	p53	CHEBI:16240	7157	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Here , we showed that exogenous H2O2 induces a rapid phosphorylation and co-localization of ATM , H2A.X , 53BP1 leading to DNA damage response -LRB- DDR -RRB- activation .
12721309	0	H2O2	35,39	Bcl-xL	14,20	H2O2	Bcl-xL	CHEBI:16240	24888(Tax:10116)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of Bcl-xL expression by H2O2 in cardiac myocytes .
25582859	0	H2O2	14,18	Cxcl8	29,34	H2O2	Cxcl8	CHEBI:16240	100002946(Tax:7955)	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Duox1-Derived H2O2 Modulates Cxcl8 Expression and Neutrophil Recruitment via JNK/c-JUN/AP -1 Signaling and Chromatin Modifications .
22807997	0	H2O2	0,4	FLT3	30,34	H2O2	FLT3	CHEBI:16240	2322	Chemical	Gene	downstream|compound|START_ENTITY downstream|nmod|END_ENTITY	H2O2 production downstream of FLT3 is mediated by p22phox in the endoplasmic reticulum and is required for STAT5 signalling .
12244106	1	H2O2	109,113	Glutaredoxin	52,64	H2O2	Glutaredoxin	CHEBI:16240	2745	Chemical	Gene	mediated|nmod|START_ENTITY mediated|nsubj|END_ENTITY	Glutaredoxin as a sensor of oxidative stress mediated by H2O2 .
18467915	0	H2O2	160,164	Glutathione_peroxidase_2	0,24	H2O2	Glutathione peroxidase 2	CHEBI:16240	14776(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Glutathione_peroxidase_2 and aquaporin_8 as new markers for colonic_inflammation in experimental colitis and inflammatory_bowel_diseases : an important role for H2O2 ?
15950497	0	H2O2	55,59	IL-1beta	23,31	H2O2	IL-1beta	CHEBI:16240	281251(Tax:9913)	Chemical	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Comparative effects of IL-1beta and hydrogen_peroxide -LRB- H2O2 -RRB- on catabolic and anabolic gene expression in juvenile bovine chondrocytes .
2509562	0	H2O2	14,18	IL-4	0,4	H2O2	IL-4	CHEBI:16240	3565	Chemical	Gene	production|compound|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	IL-4 inhibits H2O2 production and antileishmanial capacity of human cultured monocytes mediated by IFN-gamma .
22923033	0	H2O2	21,25	LGR5	13,17	H2O2	LGR5	CHEBI:16240	8549	Chemical	Gene	treatment|compound|START_ENTITY END_ENTITY|nmod|treatment	Induction of LGR5 by H2O2 treatment is associated with cell proliferation via the JNK signaling pathway in colon_cancer cells .
24323505	0	H2O2	16,20	MPK1/2	61,67	H2O2	MPK1/2	CHEBI:16240	543792;543879	Chemical	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	RBOH1-dependent H2O2 production and subsequent activation of MPK1/2 play an important role in acclimation-induced cross-tolerance in tomato .
14753751	0	H2O2	63,67	NF-kappaB	31,40	H2O2	NF-kappaB	CHEBI:16240	4790	Chemical	Gene	induced|nmod|START_ENTITY activation|acl|induced activation|amod|END_ENTITY	Aspirin prevents apoptosis and NF-kappaB activation induced by H2O2 in hela cells .
17339489	0	H2O2	48,52	NF-kappaB	24,33	H2O2	NF-kappaB	CHEBI:16240	4790	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	A quantitative study of NF-kappaB activation by H2O2 : relevance in inflammation and synergy with TNF-alpha .
22135900	2	H2O2	125,129	NF-kappaB	147,156	H2O2	NF-kappaB	CHEBI:16240	4790	Chemical	Gene	induction|nummod|START_ENTITY induction|nmod|pathway pathway|amod|END_ENTITY	-LRB- Agaricomycetideae -RRB- substances interfere with H2O2 induction of the NF-kappaB pathway through inhibition of Ikappaalpha phosphorylation in MCF7 breast_cancer cells .
23555559	0	H2O2	17,21	NOX4	35,39	H2O2	NOX4	CHEBI:16240	50507	Chemical	Gene	role|nmod|START_ENTITY generated|nsubj|role generated|nmod|END_ENTITY	Critical role of H2O2 generated by NOX4 during cellular response under glucose_deprivation .
14966267	0	H2O2	76,80	Nox4	28,32	H2O2	Nox4	CHEBI:16240	50507	Chemical	Gene	generation|nmod|START_ENTITY modulates|dobj|generation modulates|nsubj|oxidase oxidase|acl|homolog homolog|dobj|END_ENTITY	The NAD -LRB- P -RRB- H oxidase homolog Nox4 modulates insulin-stimulated generation of H2O2 and plays an integral role in insulin signal transduction .
15848200	0	H2O2	0,4	Nox4	15,19	H2O2	Nox4	CHEBI:16240	50507	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	H2O2 activates Nox4 through PLA2-dependent arachidonic_acid production in adult cardiac_fibroblasts .
22037513	0	H2O2	44,48	Nrf2	21,25	H2O2	Nrf2	CHEBI:16240	4780	Chemical	Gene	astrocytes|nmod|START_ENTITY END_ENTITY|nmod|astrocytes	Polyphenols activate Nrf2 in astrocytes via H2O2 , semiquinones , and quinones .
25943695	0	H2O2	32,36	Prdx4	0,5	H2O2	Prdx4	D006861	10549	Chemical	Gene	sensor|compound|START_ENTITY sensor|nsubj|END_ENTITY	Prdx4 is a compartment-specific H2O2 sensor that regulates neurogenesis by controlling surface expression of GDE2 .
25943695	0	H2O2	32,36	Prdx4	0,5	H2O2	Prdx4	D006861	10549	Chemical	Gene	sensor|compound|START_ENTITY sensor|nsubj|END_ENTITY	Prdx4 is a compartment-specific H2O2 sensor that regulates neurogenesis by controlling surface expression of GDE2 .
14572613	0	H2O2	32,36	Prdx6	18,23	H2O2	Prdx6	CHEBI:16240	11758(Tax:10090)	Chemical	Gene	reduces|dobj|START_ENTITY reduces|nsubj|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of Prdx6 reduces H2O2 but does not prevent diet-induced atherosclerosis in the aortic root .
16207710	0	H2O2	100,104	SMO	17,20	H2O2	SMO	CHEBI:16240	6608	Chemical	Gene	source|nmod|START_ENTITY source|nsubj|END_ENTITY	Spermine oxidase SMO -LRB- PAOh1 -RRB- , Not N1-acetylpolyamine oxidase PAO , is the primary source of cytotoxic H2O2 in polyamine analogue-treated human breast_cancer cell lines .
26655928	0	H2O2	88,92	TGF-b	97,102	H2O2	TGF-b	D006861	7040	Chemical	Gene	START_ENTITY|nmod|pathway pathway|amod|END_ENTITY	Akbu-LAAO exhibits potent anti-tumor activity to HepG2 cells partially through produced H2O2 via TGF-b signal pathway .
26907473	0	H2O2	45,49	TRPV1	27,32	H2O2	TRPV1	D006861	193034(Tax:10090)	Chemical	Gene	channels|nmod|START_ENTITY channels|nummod|END_ENTITY	Differential regulation of TRPV1 channels by H2O2 : implications for diabetic_microvascular_dysfunction .
11013218	0	H2O2	0,4	Yap1	38,42	H2O2	Yap1	CHEBI:16240	855005(Tax:4932)	Chemical	Gene	START_ENTITY|acl|sensing sensing|nmod|oxidation oxidation|nmod|factor factor|amod|END_ENTITY	H2O2 sensing through oxidation of the Yap1 transcription factor .
17707237	0	H2O2	87,91	Yap1	38,42	H2O2	Yap1	CHEBI:16240	855005(Tax:4932)	Chemical	Gene	signal|compound|START_ENTITY sensing|nmod|signal required|nmod|sensing required|nsubjpass|formation formation|nmod|END_ENTITY	Multistep disulfide bond formation in Yap1 is required for sensing and transduction of H2O2 stress signal .
20971184	0	H2O2	19,23	Yap1	0,4	H2O2	Yap1	CHEBI:16240	855005(Tax:4932)	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Yap1 activation by H2O2 or thiol-reactive chemicals elicits distinct adaptive gene responses .
1725105	0	H2O2	99,103	alpha-2-macroglobulin	69,90	H2O2	alpha-2-macroglobulin	CHEBI:16240	2	Chemical	Gene	release|compound|START_ENTITY release|amod|END_ENTITY	The main serum protease inhibitors ; alpha-1-proteinase inhibitor and alpha-2-macroglobulin inhibit H2O2 release from human polymorphonuclear leukocytes stimulated with phorbol_myristate_acetate .
26543792	0	H2O2	60,64	caspase-3	47,56	H2O2	caspase-3	D006861	100194892(Tax:8030)	Chemical	Gene	induced|compound|START_ENTITY END_ENTITY|nmod|induced	Hydrolyzed fish proteins reduced activation of caspase-3 in H2O2 induced oxidative stressed liver cells isolated from Atlantic_salmon -LRB- Salmo_salar -RRB- .
7144739	0	H2O2	77,81	cytochrome_P-450	103,119	H2O2	cytochrome P-450	CHEBI:16240	25251(Tax:10116)	Chemical	Gene	START_ENTITY|acl|generated generated|nmod|END_ENTITY	The opposing effects of N-hydroxyamphetamine and N-hydroxyphentermine on the H2O2 generated by hepatic cytochrome_P-450 .
9675879	0	H2O2	47,51	cytochrome_c	34,46	H2O2	cytochrome c	CHEBI:16240	54205	Chemical	Gene	system|compound|START_ENTITY system|amod|END_ENTITY	Production of melanin pigments by cytochrome_c / H2O2 system .
17150203	0	H2O2	15,19	hCG	33,36	H2O2	hCG	CHEBI:16240	3342	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Dual action of H2O2 on placental hCG secretion : implications for oxidative stress in preeclampsia .
2823714	0	H2O2	88,92	lactoperoxidase	62,77	H2O2	lactoperoxidase	CHEBI:16240	4025	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of hydroxyl radicals in irreversible inactivation of lactoperoxidase by excess H2O2 .
9829991	0	H2O2	90,94	low_molecular_weight_phosphotyrosine-protein_phosphatase	30,86	H2O2	low molecular weight phosphotyrosine-protein phosphatase	CHEBI:16240	52	Chemical	Gene	mechanism|nmod|START_ENTITY mechanism|nmod|END_ENTITY	The inactivation mechanism of low_molecular_weight_phosphotyrosine-protein_phosphatase by H2O2 .
24036910	0	H2O2	127,131	macrophage_migration_inhibitory_factor	77,115	H2O2	macrophage migration inhibitory factor	CHEBI:16240	17319(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Involvement of Src tyrosine kinase and protein_kinase_C in the expression of macrophage_migration_inhibitory_factor induced by H2O2 in HL-1 mouse cardiac muscle cells .
15023565	0	H2O2	48,52	p38	54,57	H2O2	p38	CHEBI:16240	5594	Chemical	Gene	Kinase|compound|START_ENTITY Kinase|amod|END_ENTITY	Native LDL induces interleukin-8 expression via H2O2 , p38 Kinase , and activator_protein-1 in human aortic smooth muscle cells .
26150388	0	H2O2	31,35	peroxiredoxin_I	45,60	H2O2	peroxiredoxin I	D006861	5052	Chemical	Gene	level|compound|START_ENTITY level|nmod|END_ENTITY	Control of the pericentrosomal H2O2 level by peroxiredoxin_I is critical for mitotic progression .
15313177	0	H2O2	48,52	phenylalanine_hydroxylase	6,31	H2O2	phenylalanine hydroxylase	CHEBI:16240	5053	Chemical	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	Human phenylalanine_hydroxylase is activated by H2O2 : a novel mechanism for increasing the L-tyrosine supply for melanogenesis in melanocytes .
8063203	0	H2O2	11,15	protein_tyrosine_phosphatase	19,47	H2O2	protein tyrosine phosphatase	CHEBI:16240	26191	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|amod|END_ENTITY	Effects of H2O2 on protein_tyrosine_phosphatase activity in HER14 cells .
20211239	0	H2O2	76,80	telomerase_reverse_transcriptase	32,64	H2O2	telomerase reverse transcriptase	CHEBI:16240	7015	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Downregulation of mitochondrial telomerase_reverse_transcriptase induced by H2O2 is Src kinase dependent .
24336065	0	H2S	15,18	CYP2B6	40,46	H2S	CYP2B6	CHEBI:36945	286953(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activities activities|nmod|END_ENTITY	The effects of H2S on the activities of CYP2B6 , CYP2D6 , CYP3A4 , CYP2C19 and CYP2C9 in vivo in rat .
20067446	0	H2S	0,3	IL-6	23,27	H2S	IL-6	CHEBI:36945	3569	Chemical	Gene	blocks|nsubj|START_ENTITY blocks|dobj|expression expression|compound|END_ENTITY	H2S transiently blocks IL-6 expression in rheumatoid arthritic fibroblast-like synoviocytes and deactivates p44/42 mitogen-activated protein kinase .
17989210	0	H2S	0,3	PKC	28,31	H2S	PKC	CHEBI:36945	24681(Tax:10116)	Chemical	Gene	activation|nummod|START_ENTITY activation|compound|END_ENTITY	H2S preconditioning-induced PKC activation regulates intracellular calcium handling in rat cardiomyocytes .
16222244	0	H3_serine	8,17	Aurora_B	40,48	H3 serine	Aurora B	null	9212	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Histone H3_serine 10 phosphorylation by Aurora_B causes HP1 dissociation from heterochromatin .
23409115	0	HA-1077	31,38	ROCK	42,46	HA-1077	ROCK	MESH:C049347	43916(Tax:7227)	Chemical	Gene	administration|nmod|START_ENTITY administration|appos|inhibitor inhibitor|compound|END_ENTITY	Intravitreal administration of HA-1077 , a ROCK inhibitor , improves retinal function in a mouse model of huntington_disease .
8740642	0	HAMA	117,121	CA125	101,106	HAMA	CA125	null	94025	Chemical	Gene	caused|nmod|START_ENTITY END_ENTITY|acl|caused	Immunoglobulin Inhibiting Reagent : evaluation of a new method for eliminating spurious elevations in CA125 caused by HAMA .
23750020	0	HAMI_3379	0,9	CysLT2	13,19	HAMI 3379	CysLT2	MESH:C549635	57105	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	HAMI_3379 , a CysLT2 receptor antagonist , attenuates ischemia-like neuronal_injury by inhibiting microglial activation .
6220772	0	HB_699	85,91	pancreatic_polypeptide	100,122	HB 699	pancreatic polypeptide	MESH:C030516	490944(Tax:9615)	Chemical	Gene	derivative|nmod|START_ENTITY Effect|nmod|derivative Effect|nmod|secretion secretion|amod|END_ENTITY	-LSB- Effect of chronic administration of an acylamino_alcoyl derivative of benzoic_acid , HB_699 , on the pancreatic_polypeptide secretion in the dog -RSB- .
6340523	0	HB_699	81,87	pancreatic_polypeptide	15,37	HB 699	pancreatic polypeptide	MESH:C030516	490944(Tax:9615)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Stimulation Stimulation|nmod|END_ENTITY	Stimulation of pancreatic_polypeptide secretion in the dog by hypoglycemic agent HB_699 .
18954467	0	HC-030031	0,9	TRPA1	13,18	HC-030031	TRPA1	MESH:C552888	8989	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	HC-030031 , a TRPA1 selective antagonist , attenuates inflammatory - and neuropathy-induced mechanical hypersensitivity .
11698238	0	HCO	24,27	Neurotrophin-3	0,14	HCO	Neurotrophin-3	CHEBI:17478	81737(Tax:10116)	Chemical	Gene	absorption|compound|START_ENTITY inhibits|dobj|absorption inhibits|nsubj|END_ENTITY	Neurotrophin-3 inhibits HCO absorption via a cAMP-dependent pathway in renal thick ascending limb .
10330055	0	HCO-3	24,29	Angiotensin_II	0,14	HCO-3	Angiotensin II	CHEBI:17544	24179(Tax:10116)	Chemical	Gene	absorption|compound|START_ENTITY inhibits|dobj|absorption inhibits|nsubj|END_ENTITY	Angiotensin_II inhibits HCO-3 absorption via a cytochrome_P-450-dependent pathway in MTAL .
441571	0	HCO-3	36,41	CSF	31,34	HCO-3	CSF	CHEBI:17544	403923(Tax:9615)	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	Role of PCO2 as determinant of CSF -LSB- HCO-3 -RSB- in metabolic_acidosis .
939224	0	HCO-3	52,57	pyruvate_carboxylase	76,96	HCO-3	pyruvate carboxylase	CHEBI:17544	5091	Chemical	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Apparent co-operative effect of hydrogen_carbonate -LRB- HCO-3 -RRB- on pigeon kidney pyruvate_carboxylase .
18060642	0	HCPT	21,25	HIF-1alpha	43,53	HCPT	HIF-1alpha	MESH:C120029	3091	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|nmod|END_ENTITY	Inhibitory effect of HCPT on expression of HIF-1alpha and downstream genes in hypoxic human cervical SiHa_cancer cells .
15686492	0	HCT1026	133,140	peroxisome_proliferator-activated_receptor-gamma	17,65	HCT1026	peroxisome proliferator-activated receptor-gamma	MESH:C095631	25664(Tax:10116)	Chemical	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	Nuclear receptor peroxisome_proliferator-activated_receptor-gamma is activated in rat microglial cells by the anti-inflammatory drug HCT1026 , a derivative of flurbiprofen .
15674237	0	HCl	38,41	5-HT1A_receptor	45,60	HCl	5-HT1A receptor	CHEBI:17883	3350	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Neuroprotective efficacy of repinotan HCl , a 5-HT1A_receptor agonist , in animal models of stroke and traumatic_brain_injury .
21607240	0	HCl	70,73	Cl2	52,55	HCl	Cl2	CHEBI:17883	100862695	Chemical	Gene	oxidation|compound|START_ENTITY END_ENTITY|nmod|oxidation	A delafossite-based copper catalyst for sustainable Cl2 production by HCl oxidation .
25925258	0	HCl	27,30	ENaC	0,4	HCl	ENaC	CHEBI:17883	20276(Tax:10090)	Chemical	Gene	secretion|compound|START_ENTITY secretion|amod|END_ENTITY	ENaC inhibition stimulates HCl secretion in the mouse cortical collecting duct I : stilbene-sensitive Cl - secretion .
23916045	0	HCl	28,31	familial_hypercholesterolemia	65,94	HCl	familial hypercholesterolemia	CHEBI:17883	3949	Chemical	Gene	START_ENTITY|nmod|treatment treatment|nmod|END_ENTITY	The efficacy of colesevelam HCl in the treatment of heterozygous familial_hypercholesterolemia in pediatric and adult patients .
2887352	0	HCl	43,46	mucin	22,27	HCl	mucin	CHEBI:17883	442975(Tax:9615)	Chemical	Gene	response|nmod|START_ENTITY END_ENTITY|nmod|response	Intestinal release of mucin in response to HCl and taurocholate : effect of indomethacin .
6994510	0	HCl	33,36	renin	14,19	HCl	renin	CHEBI:17883	403838(Tax:9615)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Inhibition of renin secretion by HCl is related to chloride in both dog and rat .
7805235	0	HCl	55,58	renin	30,35	HCl	renin	CHEBI:17883	403838(Tax:9615)	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|zankiren zankiren|compound|END_ENTITY	Dose-dependent effects of the renin inhibitor zankiren HCl after a single oral dose in mildly sodium-depleted normotensive subjects .
4815082	0	HCl	43,46	secretin	89,97	HCl	secretin	CHEBI:17883	483407(Tax:9615)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|acl|circulating circulating|dobj|END_ENTITY	Effects of intraduodenal administration of HCl and glucose on circulating immunoreactive secretin and insulin concentrations .
21072520	0	HDAC42	25,31	histone_deacetylase	58,77	HDAC42	histone deacetylase	MESH:C524513	9734	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Antitumor effects of -LRB- S -RRB- - HDAC42 , a phenylbutyrate-derived histone_deacetylase inhibitor , in multiple_myeloma cells .
23010268	0	HEA	50,53	BACE-1	55,61	HEA	BACE-1	CHEBI:16000	23621	Chemical	Gene	inhibitors|appos|START_ENTITY inhibitors|compound|END_ENTITY	Design and synthesis of potent hydroxyethylamine -LRB- HEA -RRB- BACE-1 inhibitors carrying prime side 4,5,6,7-tetrahydrobenzazole and 4,5,6,7-tetrahydropyridinoazole templates .
26915506	0	HEA	37,40	BACE1	56,61	HEA	BACE1	CHEBI:16000	23621	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	Interaction mechanism exploration of HEA derivatives as BACE1 inhibitors by in silico analysis .
15825077	9	HEPH	1168,1172	CDX2	1147,1151	HEPH	HEPH	null	9843	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Activation of CDX2 rapidly induced HEPH expression , and RNA interference-mediated inhibition of CDX2 led to lower HEPH expression .
11714595	0	HET0016	54,61	20-HETE_synthase	88,104	HET0016	20-HETE synthase	MESH:C433446	1579	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|amod|END_ENTITY	Discovery of a N ' - hydroxyphenylformamidine derivative HET0016 as a potent and selective 20-HETE_synthase inhibitor .
23103566	0	HFCS-55	55,62	PPAR	73,77	HFCS-55	PPAR	null	19013(Tax:10090)	Chemical	Gene	intake|compound|START_ENTITY intake|nmod|END_ENTITY	Reversal of the deleterious effects of chronic dietary HFCS-55 intake by PPAR - agonism correlates with impaired NLRP3 inflammasome activation .
10566233	0	HI-6	99,103	acetylcholinesterase	137,157	HI-6	acetylcholinesterase	MESH:C022870	83817(Tax:10116)	Chemical	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|END_ENTITY	-LSB- Comparison of the reactivating effect of BI-6 , a new asymmetrical bispyridinium_oxime , with oxime HI-6 and obidoxime on soman-inhibited acetylcholinesterase in the diaphragm and various parts of the brain in rats -RSB- .
12907237	0	HI-6	33,37	acetylcholinesterase	96,116	HI-6	acetylcholinesterase	MESH:C022870	11423(Tax:10090)	Chemical	Gene	molecule|compound|START_ENTITY orientations|nmod|molecule orientations|nmod|reactivation reactivation|nmod|END_ENTITY	Two possible orientations of the HI-6 molecule in the reactivation of organophosphate-inhibited acetylcholinesterase .
16876764	0	HI-6	59,63	acetylcholinesterase	22,42	HI-6	acetylcholinesterase	MESH:C022870	11423(Tax:10090)	Chemical	Gene	complex|nmod|START_ENTITY END_ENTITY|nmod|complex	Crystal structures of acetylcholinesterase in complex with HI-6 , Ortho-7 and obidoxime : structural basis for differences in the ability to reactivate tabun conjugates .
18254274	0	HI-6	65,69	acetylcholinesterase	116,136	HI-6	acetylcholinesterase	MESH:C022870	43	Chemical	Gene	obidoxime|compound|START_ENTITY pralidoxime|dep|obidoxime oximes|appos|pralidoxime oximes|nmod|END_ENTITY	Evaluation of potency of known oximes -LRB- pralidoxime , trimedoxime , HI-6 , methoxime , obidoxime -RRB- to in vitro reactivate acetylcholinesterase inhibited by pesticides -LRB- chlorpyrifos and methylchlorpyrifos -RRB- and nerve agent -LRB- Russian VX -RRB- .
21054236	0	HI-6	93,97	acetylcholinesterase	42,62	HI-6	acetylcholinesterase	MESH:C022870	83817(Tax:10116)	Chemical	Gene	oximes|dep|START_ENTITY END_ENTITY|nmod|oximes	A comparison of tabun-inhibited rat brain acetylcholinesterase reactivation by three oximes -LRB- HI-6 , obidoxime , and K048 -RRB- in vivo detected by biochemical and histochemical techniques .
23376121	0	HI-6	120,124	acetylcholinesterase	68,88	HI-6	acetylcholinesterase	MESH:C022870	43	Chemical	Gene	specificity|compound|START_ENTITY implications|nmod|specificity equilibrium|dep|implications equilibrium|nmod|adducts adducts|nmod|END_ENTITY	Catalytic-site conformational equilibrium in nerve-agent adducts of acetylcholinesterase : possible implications for the HI-6 antidote substrate specificity .
27083141	0	HI-6	0,4	acetylcholinesterase	44,64	HI-6	acetylcholinesterase	MESH:C022870	11423(Tax:10090)	Chemical	Gene	assisted|nsubj|START_ENTITY assisted|nmod|mutants mutants|amod|choline choline|amod|END_ENTITY	HI-6 assisted catalytic scavenging of VX by acetylcholinesterase choline binding site mutants .
3951676	0	HI-6	10,14	acetylcholinesterase	81,101	HI-6	acetylcholinesterase	MESH:C022870	83817(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|inhibition inhibition|nmod|END_ENTITY	Effect of HI-6 , applied into the cerebral ventricles , on the inhibition of brain acetylcholinesterase by soman in rats .
17048025	0	HI-TEX	40,46	PARP	47,51	HI-TEX	PARP	null	142	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Reconstruction of a crushed chest with HI-TEX PARP NT implant -RSB- .
14256808	0	HISTAMINE	14,23	GASTRIN	53,60	HISTAMINE	GASTRIN	MESH:D006632	25320(Tax:10116)	Chemical	Gene	CATABOLISM|compound|START_ENTITY CATABOLISM|nmod|END_ENTITY	INHIBITORS OF HISTAMINE CATABOLISM AND THE ACTION OF GASTRIN IN THE RAT .
7869831	0	HL-004	11,17	ACAT	27,31	HL-004	ACAT	MESH:C092284	100009537(Tax:9986)	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of HL-004 , a novel ACAT inhibitor , on cholesterol accumulation and removal in cultured smooth muscle cells from stroke-prone spontaneously hypertensive rats -LRB- SHRSP -RRB- .
9765329	0	HL-004	140,146	ACAT	133,137	HL-004	ACAT	MESH:C092284	100009537(Tax:9986)	Chemical	Gene	acyltransferase|appos|START_ENTITY acyltransferase|appos|END_ENTITY	Stimulation of cholesterol release from rabbit foam cells by the action of a new inhibitor for acyl_CoA : cholesterol acyltransferase -LRB- ACAT -RRB- , HL-004 .
22621254	0	HL07	60,64	RhoA	44,48	HL07	RhoA	null	387	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	The effect of first-in-class small molecule RhoA inhibitor , HL07 , on the phenylephrine-induced artery contraction .
26866467	0	HLA-Bw4	68,75	KIR3DL1	40,47	HLA-Bw4	KIR3DL1	MESH:C042388	3811	Chemical	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	The killer immunoglobulin-like receptor KIR3DL1 in combination with HLA-Bw4 is protective against multiple_sclerosis in African Americans .
26416336	0	HM01	78,82	ghrelin_receptor	52,68	HM01	ghrelin receptor	null	84022(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	Site and mechanism of the colokinetic action of the ghrelin_receptor agonist , HM01 .
25855895	0	HM30181	0,7	Breast_Cancer_Resistance_Protein	68,100	HM30181	Breast Cancer Resistance Protein	MESH:C521083	9429	Chemical	Gene	Derivatives|compound|START_ENTITY Derivatives|nmod|END_ENTITY	HM30181 Derivatives as Novel Potent and Selective Inhibitors of the Breast_Cancer_Resistance_Protein -LRB- BCRP/ABCG2 -RRB- .
22284902	0	HM30181	69,76	P-glycoprotein	43,57	HM30181	P-glycoprotein	MESH:C521083	5243	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Tolerability and pharmacokinetics of a new P-glycoprotein inhibitor , HM30181 , in healthy Korean male volunteers : single - and multiple-dose randomized , placebo-controlled studies .
23022332	0	HM30181	15,22	P-glycoprotein	28,42	HM30181	P-glycoprotein	MESH:C521083	67078(Tax:10090)	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of HM30181 with P-glycoprotein at the murine blood-brain barrier assessed with positron emission tomography .
23829508	0	HM30181	89,96	P-glycoprotein	100,114	HM30181	P-glycoprotein	MESH:C521083	5243	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|compound|END_ENTITY	Sustained Increase in the Oral Bioavailability of Loperamide after a Single Oral Dose of HM30181 , a P-glycoprotein Inhibitor , in Healthy Male Participants .
23829508	0	HM30181	89,96	P-glycoprotein	100,114	HM30181	P-glycoprotein	MESH:C521083	5243	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|compound|END_ENTITY	Sustained Increase in the Oral Bioavailability of Loperamide after a Single Oral Dose of HM30181 , a P-glycoprotein Inhibitor , in Healthy Male Participants .
24602137	0	HM30181	11,18	P-glycoprotein	22,36	HM30181	P-glycoprotein	MESH:C521083	5243	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effects of HM30181 , a P-glycoprotein inhibitor , on the pharmacokinetics and pharmacodynamics of loperamide in healthy volunteers .
10856751	2	HMA	361,364	gag	357,360	HMA	env	null	30816	Chemical	Gene	subtype|compound|START_ENTITY subtype|compound|END_ENTITY	There was complete concordance between the gag HMA assigned subtype and the subtype known from gag or env sequence data or env HMA .
19327767	0	HMG-CoA	16,23	HMGCR	35,40	HMG-CoA	HMGCR	MESH:C008047	3156	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Variants in the HMG-CoA reductase -LRB- HMGCR -RRB- gene influence component phenotypes in polycystic_ovary_syndrome .
8236126	0	HMG-CoA	47,54	fibrinogen	86,96	HMG-CoA	fibrinogen	MESH:C008047	2244	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Effect of three fibrate derivatives and of two HMG-CoA reductase inhibitors on plasma fibrinogen level in patients with primary_hypercholesterolemia .
24919794	0	HMJ-30	19,25	death_receptor_5	116,132	HMJ-30	death receptor 5	MESH:C560913	8795	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Quinazoline analog HMJ-30 inhibits angiogenesis : involvement of endothelial cell apoptosis through ROS-JNK-mediated death_receptor_5 signaling .
15518626	0	HMR_3339	10,18	C-reactive_protein	70,88	HMR 3339	C-reactive protein	MESH:C495287	1401	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|amod|END_ENTITY	Effect of HMR_3339 , a novel selective estrogen receptor modulator , on C-reactive_protein levels in healthy postmenopausal women .
8165627	0	HN-11500	0,8	thromboxane_A2_receptor	18,41	HN-11500	thromboxane A2 receptor	MESH:C090807	6915	Chemical	Gene	START_ENTITY|dep|antagonist antagonist|amod|END_ENTITY	HN-11500 -- a novel thromboxane_A2_receptor antagonist with antithrombotic activity in humans at arterial blood flow conditions .
10763850	0	HN-56249	56,64	cyclooxygenase-2	28,44	HN-56249	cyclooxygenase-2	null	5743	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Pharmacology of a selective cyclooxygenase-2 inhibitor , HN-56249 : a novel compound exhibiting a marked preference for the human enzyme in intact cells .
8703667	0	HN-65021	14,22	angiotensin_II	39,53	HN-65021	angiotensin II	MESH:C098801	183	Chemical	Gene	START_ENTITY|nmod|responses responses|nmod|END_ENTITY	The effect of HN-65021 on responses to angiotensin_II in human forearm vasculature .
26466521	5	HNK	723,726	STAT3	756,761	HNK	STAT3	null	6774	Chemical	Gene	decreased|nsubj|START_ENTITY decreased|dobj|END_ENTITY	HNK decreased the phosphorylated STAT3 but not the total STAT3 through increasing the expression of SHP1 .
23919584	0	HNO	0,3	SERCA2a	13,20	HNO	SERCA2a	null	11938(Tax:10090)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|amod|END_ENTITY	HNO enhances SERCA2a activity and cardiomyocyte function by promoting redox-dependent phospholamban oligomerization .
22863710	0	HNO	83,86	calcitonin_gene-related_peptide	29,60	HNO	calcitonin gene-related peptide	null	796	Chemical	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	Photoinduced upregulation of calcitonin_gene-related_peptide in A549 cells through HNO release from a hydrophilic photocontrollable HNO donor .
21885917	0	HO-3867	0,7	STAT3	117,122	HO-3867	STAT3	MESH:C541427	6774	Chemical	Gene	sensitizes|nsubj|START_ENTITY sensitizes|advcl|leading leading|nmod|inhibition inhibition|compound|END_ENTITY	HO-3867 , a curcumin analog , sensitizes cisplatin-resistant ovarian_carcinoma , leading to therapeutic synergy through STAT3 inhibition .
22801507	0	HO-3867	0,7	STAT3	11,16	HO-3867	STAT3	MESH:C541427	6774	Chemical	Gene	induces|ccomp|START_ENTITY induces|nsubj|inhibitor inhibitor|compound|END_ENTITY	HO-3867 , a STAT3 inhibitor induces apoptosis by inactivation of STAT3 activity in BRCA1-mutated ovarian_cancer cells .
22801507	0	HO-3867	0,7	STAT3	64,69	HO-3867	STAT3	MESH:C541427	6774	Chemical	Gene	induces|ccomp|START_ENTITY induces|nmod|inactivation inactivation|nmod|activity activity|nummod|END_ENTITY	HO-3867 , a STAT3 inhibitor induces apoptosis by inactivation of STAT3 activity in BRCA1-mutated ovarian_cancer cells .
24590057	0	HO-3867	0,7	STAT3	16,21	HO-3867	STAT3	MESH:C541427	6774	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	HO-3867 , a safe STAT3 inhibitor , is selectively cytotoxic to ovarian_cancer .
25038288	0	HO-3867	80,87	STAT3	97,102	HO-3867	STAT3	MESH:C541427	6774	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Aberrantly activated pSTAT3-Ser727 in human endometrial_cancer is suppressed by HO-3867 , a novel STAT3 inhibitor .
1321719	0	HOCl	45,49	myeloperoxidase	12,27	HOCl	myeloperoxidase	CHEBI:24757	4353	Chemical	Gene	Reaction|nmod|START_ENTITY Reaction|nmod|END_ENTITY	Reaction of myeloperoxidase with its product HOCl .
3023553	0	HOE498	124,130	renin	48,53	HOE498	renin	MESH:D017257	5972	Chemical	Gene	changes|appos|START_ENTITY changes|nmod|END_ENTITY	Twenty-four hour changes in active and inactive renin after various oral doses of the converting enzyme inhibitor ramipril -LRB- HOE498 -RRB- in normal man .
12574004	0	HOE_140	105,112	bradykinin	139,149	HOE 140	bradykinin	MESH:C065679	3827	Chemical	Gene	efficacy|nmod|START_ENTITY increase|dobj|efficacy increase|dep|not not|nmod|END_ENTITY	Changes in amino-terminal portion of human B2_receptor selectively increase efficacy of synthetic ligand HOE_140 but not of cognate ligand bradykinin .
3019702	0	HOE_498	112,119	angiotensin_converting_enzyme	62,91	HOE 498	angiotensin converting enzyme	MESH:D017257	1636	Chemical	Gene	Studies|appos|START_ENTITY Studies|nmod|effect effect|nmod|doses doses|nmod|ramipril ramipril|amod|END_ENTITY	Studies on the antihypertensive effect of single doses of the angiotensin_converting_enzyme inhibitor ramipril -LRB- HOE_498 -RRB- in man .
3034016	0	HOE_498	106,113	angiotensin_converting_enzyme	55,84	HOE 498	angiotensin converting enzyme	MESH:D017257	1636	Chemical	Gene	effects|appos|START_ENTITY effects|nmod|inhibitor inhibitor|compound|END_ENTITY	Efficacy , tolerance and hormonal effects of a new oral angiotensin_converting_enzyme inhibitor , ramipril -LRB- HOE_498 -RRB- , in mild to moderate primary hypertension .
6097458	0	HOE_498	104,111	angiotensin_converting_enzyme	63,92	HOE 498	angiotensin converting enzyme	MESH:D017257	1636	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Pharmacokinetics and pharmacodynamics of a novel orally active angiotensin_converting_enzyme inhibitor -LRB- HOE_498 -RRB- in healthy subjects .
2987705	0	HOE_498	46,53	renin	61,66	HOE 498	renin	MESH:D017257	5972	Chemical	Gene	START_ENTITY|nmod|system system|amod|END_ENTITY	The effect of the converting enzyme inhibitor HOE_498 on the renin angiotensin system of normal volunteers .
3089762	0	HOE_766	84,91	gonadotropin-releasing_hormone	45,75	HOE 766	gonadotropin-releasing hormone	MESH:D002064	2796	Chemical	Gene	analog|appos|START_ENTITY analog|amod|END_ENTITY	In vivo and in vitro stimulatory effect of a gonadotropin-releasing_hormone analog -LRB- HOE_766 -RRB- on spermatogonial multiplication in the frog , Rana esculenta .
16726114	0	HOG	170,173	GnRH	130,134	HOG	GnRH	null	2796	Chemical	Gene	gonadotropin-releasing_hormone|appos|START_ENTITY gonadotropin-releasing_hormone|appos|END_ENTITY	Progesterone secretion by induced corpora lutea -LRB- CL -RRB- of anestrous bitches after administration of gonadotropin-releasing_hormone -LRB- GnRH -RRB- and human chorionic gonadotropin -LRB- HOG -RRB- .
23691217	0	HPP593	55,61	Peroxisome_proliferator-activated_receptor	0,42	HPP593	Peroxisome proliferator-activated receptor	null	25747(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Peroxisome_proliferator-activated_receptor agonist , HPP593 , prevents renal_necrosis under chronic ischemia .
16547010	0	HQL-79	46,52	prostaglandin_D_synthase	107,131	HQL-79	prostaglandin D synthase	MESH:C116322	5730	Chemical	Gene	characterization|nmod|START_ENTITY characterization|appos|inhibitor inhibitor|nmod|END_ENTITY	Structural and functional characterization of HQL-79 , an orally selective inhibitor of human hematopoietic prostaglandin_D_synthase .
24819705	0	HS-104	0,6	PI3K	10,14	HS-104	PI3K	MESH:C571803	5293	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	HS-104 , a PI3K inhibitor , enhances the anticancer efficacy of gemcitabine in pancreatic_cancer .
22902995	0	HS-104	83,89	phosphoinositide_3-kinase	99,124	HS-104	phosphoinositide 3-kinase	MESH:C571803	5293	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Suppression of tumor proliferation and angiogenesis of hepatocellular_carcinoma by HS-104 , a novel phosphoinositide_3-kinase inhibitor .
22929971	0	HS-173	0,6	PI3K	47,51	HS-173	PI3K	MESH:C577242	5290	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|appos|END_ENTITY	HS-173 , a novel phosphatidylinositol_3-kinase -LRB- PI3K -RRB- inhibitor , has anti-tumor activity through promoting apoptosis and inhibiting angiogenesis .
24326778	0	HS-173	0,6	PI3K	16,20	HS-173	PI3K	MESH:C577242	5293	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	HS-173 , a novel PI3K inhibitor , attenuates the activation of hepatic stellate cells in liver fibrosis .
22929971	0	HS-173	0,6	phosphatidylinositol_3-kinase	16,45	HS-173	phosphatidylinositol 3-kinase	MESH:C577242	5290	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	HS-173 , a novel phosphatidylinositol_3-kinase -LRB- PI3K -RRB- inhibitor , has anti-tumor activity through promoting apoptosis and inhibiting angiogenesis .
23587795	0	HS-345	22,28	tropomyosin-related_kinase_A	36,64	HS-345	tropomyosin-related kinase A	null	4914	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Anti-cancer effect of HS-345 , a new tropomyosin-related_kinase_A inhibitor , on human pancreatic_cancer .
9832440	0	HS024	83,88	melanocortin-4_receptor	47,70	HS024	melanocortin-4 receptor	MESH:C116098	25635(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Discovery of a novel superpotent and selective melanocortin-4_receptor antagonist -LRB- HS024 -RRB- : evaluation in vitro and in vivo .
10214984	0	HSP-117	56,63	NK-1_receptor	31,44	HSP-117	NK-1 receptor	MESH:C119466	6869	Chemical	Gene	antagonist|dobj|START_ENTITY antagonist|nsubj|effects effects|nmod|END_ENTITY	Anti-emetic effects of a novel NK-1_receptor antagonist HSP-117 in ferrets .
8836620	0	HSR-81	94,100	beta_2-adrenoceptor	65,84	HSR-81	beta 2-adrenoceptor	MESH:C103510	24176(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Potent inhibition of spontaneous rhythmic contraction by a novel beta_2-adrenoceptor agonist , HSR-81 , in pregnant rat uterus .
12899667	0	HU-210	38,44	CB1	4,7	HU-210	CB1	MESH:C062018	25248(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	The CB1 cannabinoid receptor agonist , HU-210 , reduces levodopa-induced rotations in 6-hydroxydopamine-lesioned rats .
16148449	0	HU-210	98,104	CB1	85,88	HU-210	CB1	MESH:C062018	25248(Tax:10116)	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|withdrawal withdrawal|nmod|treatment treatment|nmod|END_ENTITY	Behavioural effects of quinpirole following withdrawal of chronic treatment with the CB1 agonist , HU-210 , in rats .
9263588	0	HVA	15,18	CA1	57,60	HVA	CA1	CHEBI:545959	310218(Tax:10116)	Chemical	Gene	currents|compound|START_ENTITY Development|nmod|currents Development|nmod|neurons neurons|compound|END_ENTITY	Development of HVA and LVA calcium currents in pyramidal CA1 neurons in the hippocampus of the rat .
9858027	0	HVA	14,17	CSF	0,3	HVA	CSF	CHEBI:545959	1437	Chemical	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	CSF levels of HVA and 5-HIAA in drug-free schizophrenic patients and healthy controls : a prospective study focused on their predictive value for outcome in schizophrenia .
24759688	0	HWY336	28,34	MKK4	56,60	HWY336	MKK4	null	6416	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	A Protoberberine derivative HWY336 selectively inhibits MKK4 and MKK7 in mammalian cells : the importance of activation loop on selectivity .
15857749	0	HX531	0,5	retinoid_X_receptor	9,28	HX531	retinoid X receptor	MESH:C438269	6256	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	HX531 , a retinoid_X_receptor antagonist , inhibited the 9-cis retinoic_acid-induced binding with steroid_receptor_coactivator-1 as detected by surface plasmon resonance .
12488138	5	H_2_O_2	864,871	NO_2	834,838	H 2 O 2	SP-A	CHEBI:16240	653509	Chemical	Gene	_|appos|START_ENTITY _|compound|END_ENTITY	Moreover , both horseradish peroxidase and myeloperoxidase -LRB- MPO -RRB- can utilize NO_2 _ - _ and hydrogen_peroxide -LRB- H_2_O_2 -RRB- as substrates to catalyze tyrosine nitration in SP-A and inhibit its lipid aggregation function .
21423692	0	Hachimijiogan	10,23	Hypoxia-Inducible_Factor-1a	69,96	Hachimijiogan	Hypoxia-Inducible Factor-1a	MESH:C054591	29560(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of Hachimijiogan against Renal Dysfunction and Involvement of Hypoxia-Inducible_Factor-1a in the Remnant Kidney Model .
3979549	1	Haemagglutinin	57,71	neuraminidase	87,100	Haemagglutinin	neuraminidase	null	4758	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Haemagglutinin inhibits viral neuraminidase .
23729583	0	Haishengsu	27,37	mdr1	69,73	Haishengsu	mdr1	MESH:C532636	18669(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|nmod|END_ENTITY	Tegillarca granosa extract Haishengsu -LRB- HSS -RRB- suppresses expression of mdr1 , BCR/ABL and sorcin in drug-resistant K562/ADM tumors in mice .
10385214	0	Halofantrine	0,12	CYP_3A4	60,67	Halofantrine	CYP 3A4	MESH:C023768	1576	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|dep|role role|nmod|END_ENTITY	Halofantrine metabolism in microsomes in man : major role of CYP_3A4 and CYP_3A5 .
26099922	0	Halofuginone	0,12	SMAD-2	41,47	Halofuginone	SMAD-2	MESH:C010176	17126(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Halofuginone inhibits phosphorylation of SMAD-2 reducing angiogenesis and leukemia burden in an acute_promyelocytic_leukemia mouse model .
12919180	0	Haloperidol	0,11	CYP2D6	91,97	Haloperidol	CYP2D6	MESH:D006220	1565	Chemical	Gene	concentration|amod|START_ENTITY concentration|nmod|END_ENTITY	Haloperidol plasma concentration in Japanese psychiatric subjects with gene duplication of CYP2D6 .
25868121	0	Haloperidol	110,121	CYP3A4	21,27	Haloperidol	CYP3A4	MESH:D006220	1576	Chemical	Gene	Pimozide|appos|START_ENTITY Concentrations|nmod|Pimozide Influence|nmod|Concentrations Influence|nmod|END_ENTITY	The Influence of the CYP3A4 * 22 Polymorphism and CYP2D6 Polymorphisms on Serum Concentrations of Aripiprazole , Haloperidol , Pimozide , and Risperidone in Psychiatric Patients .
24861518	0	Haloperidol	0,11	DCC	36,39	Haloperidol	DCC	MESH:D006220	13176(Tax:10090)	Chemical	Gene	downregulates|amod|START_ENTITY END_ENTITY|nsubj|downregulates	Haloperidol treatment downregulates DCC expression in the ventral tegmental area .
10415370	0	Haloperidol	0,11	Fos	20,23	Haloperidol	Fos	MESH:D006220	102143716	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Haloperidol induces Fos expression in the globus pallidus and substantia nigra of cynomolgus_monkeys .
2148276	0	Haloperidol	0,11	Fos	20,23	Haloperidol	Fos	MESH:D006220	2353	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|molecules molecules|amod|END_ENTITY	Haloperidol induces Fos and related molecules in intrastriatal grafts derived from fetal striatal primordia .
20304506	0	Haloperidol	0,11	Homer1a	27,34	Haloperidol	Homer1a	MESH:D006220	9456	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Haloperidol induces higher Homer1a expression than risperidone , olanzapine and sulpiride in striatal sub-regions .
20226844	0	Haloperidol	0,11	S100B	35,40	Haloperidol	S100B	MESH:D006220	6285	Chemical	Gene	START_ENTITY|dobj|release release|compound|END_ENTITY	Haloperidol and clozapine decrease S100B release from glial cells .
7905609	0	Haloperidol	0,11	c-myc	34,39	Haloperidol	c-myc	MESH:D006220	24577(Tax:10116)	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|amod|END_ENTITY	Haloperidol and oestrogens induce c-myc and c-fos expression in the anterior pituitary gland of the rat .
21250933	0	Haloperidol	0,11	clock	29,34	Haloperidol	clock	MESH:D006220	12753(Tax:10090)	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|expression expression|compound|END_ENTITY	Haloperidol alters circadian clock gene product expression in the mouse brain .
7931352	0	Haloperidol	0,11	junB	36,40	Haloperidol	junB	MESH:D006220	24517(Tax:10116)	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|amod|END_ENTITY	Haloperidol and fluphenazine induce junB gene expression in rat striatum and nucleus accumbens .
2054626	0	Haloperidol	0,11	neurotensin	44,55	Haloperidol	neurotensin	MESH:D006220	299757(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|number number|nmod|neurons neurons|amod|END_ENTITY	Haloperidol rapidly increases the number of neurotensin mRNA-expressing neurons in neostriatum of the rat brain .
9221926	0	Haloperidol	0,11	neurotensin	22,33	Haloperidol	neurotensin	MESH:D006220	67405(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Haloperidol regulates neurotensin gene expression in striatum of c-fos-deficient mice .
3580841	0	Haloperidol	0,11	proenkephalin	22,35	Haloperidol	proenkephalin	MESH:D006220	29237(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|amod|END_ENTITY	Haloperidol increases proenkephalin mRNA levels in the caudate-putamen of the rat : a quantitative study at the cellular level using in situ hybridization .
23643747	0	Haloperidol	0,11	ribosomal_protein_S6	57,77	Haloperidol	ribosomal protein S6	MESH:D006220	6194	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Haloperidol promotes mTORC1-dependent phosphorylation of ribosomal_protein_S6 via dopamine - _ and_cAMP-regulated_phosphoprotein_of_32_kDa and inhibition of protein phosphatase-1 .
1741499	0	Halothane	0,9	Ca2	42,45	Halothane	Ca2	MESH:D006221	54231(Tax:10116)	Chemical	Gene	control|amod|START_ENTITY control|nmod|END_ENTITY	Halothane alters control of intracellular Ca2 + mobilization in single rat ventricular myocytes .
10913255	0	Halothane	0,9	G_protein_coupled_receptor	23,49	Halothane	G protein coupled receptor	MESH:D006221	10663	Chemical	Gene	START_ENTITY|xcomp|binding binding|nmod|END_ENTITY	Halothane binding to a G_protein_coupled_receptor in retinal membranes by photoaffinity labeling .
8873559	0	Halothane	0,9	c-fos	48,53	Halothane	c-fos	MESH:D006221	314322(Tax:10116)	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|expression expression|amod|END_ENTITY	Halothane and diazepam inhibit ketamine-induced c-fos expression in the rat cingulate cortex .
15203158	0	Halothiophene_benzimidazoles	0,28	factor_Xa	81,90	Halothiophene benzimidazoles	factor Xa	null	2159	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Halothiophene_benzimidazoles as P1 surrogates of inhibitors of blood_coagulation factor_Xa .
16339216	0	Hamartin	0,8	polo-like_kinase_1	72,90	Hamartin	polo-like kinase 1	null	5347	Chemical	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Hamartin , the tuberous_sclerosis complex 1 gene product , interacts with polo-like_kinase_1 in a phosphorylation-dependent manner .
22037238	0	Harmaline	0,9	CYP1A1	64,70	Harmaline	CYP1A1	MESH:D006246	1543	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|END_ENTITY	Harmaline and harmalol inhibit the carcinogen-activating enzyme CYP1A1 via transcriptional and posttranslational mechanisms .
19796173	0	Harmine	0,7	DYRK1A	45,51	Harmine	DYRK1A	MESH:D006247	1859	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite formation .
21185805	0	Harmine	0,7	Dyrk1A	107,113	Harmine	Dyrk1A	MESH:D006247	1859	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|dual-specificity_tyrosine_phosphorylation-regulated_kinase_1A dual-specificity_tyrosine_phosphorylation-regulated_kinase_1A|appos|END_ENTITY	Harmine is an ATP-competitive inhibitor for dual-specificity_tyrosine_phosphorylation-regulated_kinase_1A -LRB- Dyrk1A -RRB- .
21185805	0	Harmine	0,7	dual-specificity_tyrosine_phosphorylation-regulated_kinase_1A	44,105	Harmine	dual-specificity tyrosine phosphorylation-regulated kinase 1A	MESH:D006247	1859	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Harmine is an ATP-competitive inhibitor for dual-specificity_tyrosine_phosphorylation-regulated_kinase_1A -LRB- Dyrk1A -RRB- .
19318910	0	Harmol	0,6	caspase-8	28,37	Harmol	caspase-8	MESH:C001326	841	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|amod|END_ENTITY	Harmol induces apoptosis by caspase-8 activation independently of Fas/Fas _ ligand interaction in human lung_carcinoma H596 cells .
27082319	0	Harpagoside	0,11	IL-6	23,27	Harpagoside	IL-6	MESH:C033249	3569	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Harpagoside suppresses IL-6 expression in primary human osteoarthritis chondrocytes .
16203115	0	Harpagoside	0,11	iNOS	50,54	Harpagoside	iNOS	MESH:C033249	18126(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	Harpagoside suppresses lipopolysaccharide-induced iNOS and COX-2 expression through inhibition of NF-kappa_B activation .
9348104	0	Helenalin	0,9	NF-kappaB	109,118	Helenalin	NF-kappaB	MESH:C001329	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Helenalin , an anti-inflammatory sesquiterpene_lactone from Arnica , selectively inhibits transcription factor NF-kappaB .
18789903	0	Helioxanthin	0,12	MIP-1_beta	49,59	Helioxanthin	MIP-1 beta	MESH:C505802	6351	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	Helioxanthin inhibits interleukin-1_beta-induced MIP-1_beta production by reduction of c-jun expression and binding of the c-jun/CREB1 complex to the AP-1 / CRE site of the MIP-1_beta promoter in Huh7 cells .
24954031	0	Hellebrigenin	0,13	Akt	122,125	Hellebrigenin	Akt	MESH:C001330	207	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|inhibition inhibition|nmod|END_ENTITY	Hellebrigenin induces cell cycle arrest and apoptosis in human hepatocellular_carcinoma HepG2 cells through inhibition of Akt .
3678365	0	Helodermin	0,10	prolactin	22,31	Helodermin	prolactin	MESH:C040442	24683(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|compound|END_ENTITY	Helodermin stimulates prolactin secretion in the rat .
22359619	0	Hemagglutinin	0,13	Janus_kinase_3	44,58	Hemagglutinin	Janus kinase 3	MESH:D006388	3718	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Hemagglutinin from the H5N1 virus activates Janus_kinase_3 to dysregulate innate immunity .
24008396	0	Hematein	0,8	casein_kinase_II	12,28	Hematein	casein kinase II	MESH:C007915	13000(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Hematein , a casein_kinase_II inhibitor , inhibits lung_cancer tumor growth in a murine xenograft model .
11243852	0	Hematein	0,8	vascular_cell_adhesion_molecule-1	54,87	Hematein	vascular cell adhesion molecule-1	MESH:C007915	7412	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Hematein inhibits tumor necrotic factor-alpha-induced vascular_cell_adhesion_molecule-1 and NF-kappaB-dependent gene expression in human vascular endothelial cells .
12236576	0	Hematoporphyrin	0,15	myoglobin	31,40	Hematoporphyrin	myoglobin	MESH:D006415	4151	Chemical	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Hematoporphyrin interacts with myoglobin and alters its functions .
11387216	0	Heme	0,4	Bach1	104,109	Heme	Bach1	MESH:D006418	571	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Heme mediates derepression of Maf recognition element through direct binding to transcription repressor Bach1 .
14660636	0	Heme	0,4	Bach1	115,120	Heme	Bach1	MESH:D006418	571	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Heme positively regulates the expression of beta-globin at the locus control region via the transcriptional factor Bach1 in erythroid cells .
14747657	0	Heme	0,4	Bach1	39,44	Heme	Bach1	MESH:D006418	12013(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|exchange exchange|nmod|END_ENTITY	Heme regulates the dynamic exchange of Bach1 and NF-E2-related factors in the Maf transcription factor network .
15175654	0	Heme	0,4	Bach1	78,83	Heme	Bach1	MESH:D006418	571	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|advcl|triggering triggering|dobj|export export|nmod|END_ENTITY	Heme regulates gene expression by triggering Crm1-dependent nuclear export of Bach1 .
17682061	0	Heme	0,4	Bach1	72,77	Heme	Bach1	MESH:D006418	12013(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|ubiquitination ubiquitination|nmod|END_ENTITY	Heme induces ubiquitination and degradation of the transcription factor Bach1 .
20179090	0	Heme	0,4	Bach1	58,63	Heme	Bach1	MESH:D006418	12013(Tax:10090)	Chemical	Gene	controls|nsubj|START_ENTITY controls|dobj|transcription transcription|nmod|END_ENTITY	Heme controls ferroportin1 -LRB- FPN1 -RRB- transcription involving Bach1 , Nrf2 and a MARE/ARE sequence motif at position -7007 of the FPN1 promoter .
6301690	0	Heme	0,4	CYC1	36,40	Heme	CYC1	MESH:D006418	853507(Tax:4932)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|nmod|gene gene|compound|END_ENTITY	Heme regulates transcription of the CYC1 gene of S. _ cerevisiae via an upstream activation site .
26880746	0	Heme	23,27	Cytochrome_P450	39,54	Heme	Cytochrome P450	MESH:D006418	4051	Chemical	Gene	Protein|compound|START_ENTITY Protein|nmod|END_ENTITY	Selective Targeting of Heme Protein in Cytochrome_P450 and Nitric_Oxide Synthase by Diphenyleneiodonium .
17947394	0	Heme	0,4	HCP-1	22,27	Heme	HCP-1	MESH:D006418	113235	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Heme carrier protein -LRB- HCP-1 -RRB- spatially interacts with the CD163 hemoglobin uptake pathway and is a target of inflammatory macrophage activation .
17785431	0	Heme	0,4	Hap1	35,39	Heme	Hap1	MESH:D006418	850958(Tax:4932)	Chemical	Gene	levels|amod|START_ENTITY switch|nsubj|levels switch|dobj|function function|nmod|END_ENTITY	Heme levels switch the function of Hap1 of Saccharomyces_cerevisiae between transcriptional activator and transcriptional repressor .
25496210	0	Heme	21,25	Heme_Oxygenase-1	37,53	Heme	Heme Oxygenase-1	MESH:D006418	24451(Tax:10116)	Chemical	Gene	Binding|compound|START_ENTITY Binding|nmod|END_ENTITY	Distal Regulation of Heme Binding of Heme_Oxygenase-1 Mediated by Conformational Fluctuations .
9402154	0	Heme	0,4	ICAM-1	50,56	Heme	ICAM-1	MESH:D006418	3383	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Heme induces the expression of adhesion molecules ICAM-1 , VCAM-1 , and E_selectin in vascular endothelial cells .
24464629	0	Heme	0,4	IL-1b	13,18	Heme	IL-1b	MESH:D006418	16176(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|secretion secretion|compound|END_ENTITY	Heme induces IL-1b secretion through activating NLRP3 in kidney_inflammation .
25835505	0	Heme	35,39	Myeloperoxidase	19,34	Heme	Myeloperoxidase	MESH:D006418	4353	Chemical	Gene	Destruction|compound|START_ENTITY Destruction|compound|END_ENTITY	Melatonin Prevents Myeloperoxidase Heme Destruction and the Generation of Free Iron Mediated by Self-Generated Hypochlorous_Acid .
25392956	0	Heme	105,109	Myoglobin	53,62	Heme	Myoglobin	MESH:D006418	102975021	Chemical	Gene	Proteins|compound|START_ENTITY Modification|nmod|Proteins Linkage|dep|Modification Linkage|nmod|END_ENTITY	A Novel Tyrosine-Heme C O Covalent Linkage in F43Y Myoglobin : A New Post-translational Modification of Heme Proteins .
25451928	0	Heme	132,136	Myoglobin	49,58	Heme	Myoglobin	MESH:D006418	102975021	Chemical	Gene	Histidine|nmod|START_ENTITY Mimic|nmod|Histidine Engineered|acl|Mimic Engineered|compound|END_ENTITY	Significantly Enhanced Heme Retention Ability of Myoglobin Engineered to Mimic the Third Covalent Linkage by Non-Axial Histidine to Heme -LRB- Vinyl -RRB- in Synechocystis Hemoglobin .
25451928	0	Heme	23,27	Myoglobin	49,58	Heme	Myoglobin	MESH:D006418	102975021	Chemical	Gene	Ability|compound|START_ENTITY Ability|nmod|Engineered Engineered|compound|END_ENTITY	Significantly Enhanced Heme Retention Ability of Myoglobin Engineered to Mimic the Third Covalent Linkage by Non-Axial Histidine to Heme -LRB- Vinyl -RRB- in Synechocystis Hemoglobin .
25525834	0	Heme	45,49	Myoglobin	75,84	Heme	Myoglobin	MESH:D006418	4151	Chemical	Gene	START_ENTITY|nmod|Dichroism Dichroism|nmod|END_ENTITY	Involvement of Propionate_Side Chains of the Heme in Circular Dichroism of Myoglobin : Experimental and Theoretical Analyses .
26814981	0	Heme	11,15	Myoglobin	110,119	Heme	Myoglobin	MESH:D006418	102975021	Chemical	Gene	Structure|compound|START_ENTITY Effects|nmod|Structure Effects|nmod|END_ENTITY	Effects of Heme Electronic Structure and Distal Polar Interaction on Functional and Vibrational Properties of Myoglobin .
24464629	0	Heme	0,4	NLRP3	48,53	Heme	NLRP3	MESH:D006418	216799(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|activating activating|dobj|END_ENTITY	Heme induces IL-1b secretion through activating NLRP3 in kidney_inflammation .
12453873	0	Heme	0,4	Nrf2	82,86	Heme	Nrf2	MESH:D006418	83619(Tax:10116)	Chemical	Gene	activates|nsubj|START_ENTITY activates|nmod|END_ENTITY	Heme activates the heme_oxygenase-1 gene in renal epithelial cells by stabilizing Nrf2 .
22262768	0	Heme	0,4	TNF	66,69	Heme	TNF	MESH:D006418	21926(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production .
21454703	0	Heme	0,4	c1q	20,23	Heme	c1q	MESH:D006418	712	Chemical	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Heme interacts with c1q and inhibits the classical complement pathway .
19722721	0	Heme	0,4	cystathionine_beta-synthase	25,52	Heme	cystathionine beta-synthase	MESH:D006418	875	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|activity activity|amod|END_ENTITY	Heme regulation of human cystathionine_beta-synthase activity : insights from fluorescence and Raman spectroscopy .
16877519	0	Heme	0,4	cytochrome_C	45,57	Heme	cytochrome C	MESH:D006418	54205	Chemical	Gene	states|amod|START_ENTITY ferrous|nsubj|states ferrous|xcomp|END_ENTITY	Heme coordination states of unfolded ferrous cytochrome_C .
23023396	0	Heme	0,4	cytochrome_c	61,73	Heme	cytochrome c	MESH:D006418	54205	Chemical	Gene	plane|amod|START_ENTITY orientation|nsubj|plane orientation|dobj|transfer transfer|nmod|electrodes electrodes|amod|END_ENTITY	Heme plane orientation dependent direct electron transfer of cytochrome_c at SAMs/Au electrodes with different wettability .
22471307	0	Heme	0,4	factor_VIII	14,25	Heme	factor VIII	MESH:D006418	2157	Chemical	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Heme binds to factor_VIII and inhibits its interaction with activated factor IX .
12453873	0	Heme	0,4	heme_oxygenase-1	19,35	Heme	heme oxygenase-1	MESH:D006418	24451(Tax:10116)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|gene gene|amod|END_ENTITY	Heme activates the heme_oxygenase-1 gene in renal epithelial cells by stabilizing Nrf2 .
15345152	0	Heme	135,139	heme_oxygenase-1	14,30	Heme	heme oxygenase-1	MESH:D006418	3162	Chemical	Gene	Oxygenase|compound|START_ENTITY Conference|nmod|Oxygenase advances|nmod|Conference Regulation|dep|advances Regulation|nmod|transcription transcription|amod|END_ENTITY	Regulation of heme_oxygenase-1 gene transcription : recent advances and highlights from the International Conference -LRB- Uppsala , 2003 -RRB- on Heme Oxygenase .
22859313	0	Heme	0,4	heme_oxygenase-1	48,64	Heme	heme oxygenase-1	MESH:D006418	15368(Tax:10090)	Chemical	Gene	biosynthesis|compound|START_ENTITY intermediates|nsubj|biosynthesis intermediates|xcomp|induce induce|xcomp|END_ENTITY	Heme and heme biosynthesis intermediates induce heme_oxygenase-1 and cytochrome_P450_2A5 , enzymes with putative sequential roles in heme and bilirubin metabolism : different requirement for transcription factor nuclear factor erythroid - derived 2-like 2 .
21868703	0	Heme	0,4	heme_oxygenase_1	13,29	Heme	heme oxygenase 1	MESH:D006418	3162	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Heme induces heme_oxygenase_1 via Nrf2 : role in the homeostatic macrophage response to intraplaque hemorrhage .
10981817	0	Heme	0,4	hemopexin	16,25	Heme	hemopexin	MESH:D006418	3263	Chemical	Gene	evidence|dep|START_ENTITY evidence|dep|binding binding|nmod|END_ENTITY	Heme binding by hemopexin : evidence for multiple modes of binding and functional implications .
8262649	0	Heme	110,114	hemopexin	57,66	Heme	hemopexin	MESH:D006418	100009541(Tax:9986)	Chemical	Gene	receptor|nmod|START_ENTITY receptor|compound|END_ENTITY	Identification and characterization of an iron-regulated hemopexin receptor in Haemophilus_influenzae type b. Heme can serve Haemophilus_influenzae as a source of both essential porphyrin and iron .
16042409	0	Heme	0,4	myoglobin	70,79	Heme	myoglobin	MESH:D006418	4151	Chemical	Gene	START_ENTITY|nmod|transfer transfer|nmod|END_ENTITY	Heme reduction by intramolecular electron transfer in cysteine mutant myoglobin under carbon_monoxide atmosphere .
6270470	0	Heme	0,4	tryptophan_pyrrolase	30,50	Heme	tryptophan pyrrolase	MESH:D006418	64206(Tax:10116)	Chemical	Gene	utilization|amod|START_ENTITY END_ENTITY|nsubj|utilization	Heme utilization by rat liver tryptophan_pyrrolase as a screening test for exacerbation of hepatic_porphyrias by drugs .
17925394	0	Hemin	0,5	prion_protein	70,83	Hemin	prion protein	MESH:D006427	5621	Chemical	Gene	interactions|amod|START_ENTITY interactions|nmod|END_ENTITY	Hemin interactions and alterations of the subcellular localization of prion_protein .
19693771	0	Hemoglobin	0,10	PI3K	110,114	Hemoglobin	PI3K	CHEBI:5656	5293	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Hemoglobin induces the expression of indoleamine_2 ,3 - dioxygenase in dendritic cells through the activation of PI3K , PKC , and NF-kappaB and the generation of reactive oxygen species .
12851530	0	Hemoglobin	0,10	matrix_metalloproteinase-9	49,75	Hemoglobin	matrix metalloproteinase-9	CHEBI:5656	4318	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|nmod|END_ENTITY	Hemoglobin induces the production and release of matrix_metalloproteinase-9 from human malignant cells .
14530380	0	Heparan_sulfate	0,15	BACE1	66,71	Heparan sulfate	BACE1	MESH:D006497	23621	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Heparan_sulfate regulates amyloid_precursor_protein processing by BACE1 , the Alzheimer 's beta-secretase .
2973992	0	Heparan_sulphate	0,16	antithrombin_III	38,54	Heparan sulphate	antithrombin III	CHEBI:28815	462	Chemical	Gene	START_ENTITY|nmod|affinity affinity|nmod|END_ENTITY	Heparan_sulphate with no affinity for antithrombin_III and the control of haemostasis .
17004727	0	Heparin	0,7	BACE-1	37,43	Heparin	BACE-1	MESH:D006493	23621	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|inhibitors inhibitors|nmod|END_ENTITY	Heparin derivatives as inhibitors of BACE-1 , the Alzheimer 's beta-secretase , with reduced activity against factor_Xa and other proteases .
26495958	0	Heparin	0,7	COX-2	24,29	Heparin	COX-2	MESH:D006493	4513	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Heparin and LPS-induced COX-2 expression in airway cells : a link between its anti-inflammatory effects and GAG sulfation .
22912725	0	Heparin	0,7	Hepatocyte_Growth_Factor	17,41	Heparin	Hepatocyte Growth Factor	MESH:D006493	3082	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Heparin inhibits Hepatocyte_Growth_Factor induced motility and invasion of hepatocellular_carcinoma cells through early growth response protein 1 .
10861269	0	Heparin	0,7	TNF-alpha	19,28	Heparin	TNF-alpha	MESH:D006493	24835(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|END_ENTITY	Heparin attenuates TNF-alpha induced inflammatory response through a CD11b dependent mechanism .
12640331	0	Heparin	0,7	bFGF	33,37	Heparin	bFGF	MESH:D006493	2247	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|nmod|END_ENTITY	Heparin stimulates production of bFGF and TGF-beta_1 by human normal , keloid , and fetal dermal fibroblasts .
7508153	0	Heparin	0,7	basic_fibroblast_growth_factor	114,144	Heparin	basic fibroblast growth factor	MESH:D006493	281161(Tax:9913)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|activation activation|nmod|END_ENTITY	Heparin stimulates the proliferation of bovine aortic endothelial cells probably through activation of endogenous basic_fibroblast_growth_factor .
16716081	0	Heparin	0,7	beta-secretase	18,32	Heparin	beta-secretase	MESH:D006493	23621	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Heparin activates beta-secretase -LRB- BACE1 -RRB- of Alzheimer 's _ disease and increases autocatalysis of the enzyme .
17004727	0	Heparin	0,7	beta-secretase	61,75	Heparin	beta-secretase	MESH:D006493	23621	Chemical	Gene	derivatives|compound|START_ENTITY END_ENTITY|nsubj|derivatives	Heparin derivatives as inhibitors of BACE-1 , the Alzheimer 's beta-secretase , with reduced activity against factor_Xa and other proteases .
1443220	0	Heparin	0,7	endothelin-1	19,31	Heparin	endothelin-1	MESH:D006493	24323(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|action action|amod|END_ENTITY	Heparin suppresses endothelin-1 action and production in spontaneously hypertensive rats .
8011978	0	Heparin	0,7	endothelin-1	19,31	Heparin	endothelin-1	MESH:D006493	24323(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|peptide peptide|amod|END_ENTITY	Heparin suppresses endothelin-1 peptide and mRNA expression in cultured endothelial cells of spontaneously hypertensive rats .
8127002	0	Heparin	0,7	endothelin-1	17,29	Heparin	endothelin-1	MESH:D006493	24323(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Heparin inhibits endothelin-1 production in cultured rat mesangial cells .
9595512	0	Heparin	0,7	endothelin-1	40,52	Heparin	endothelin-1	MESH:D006493	24323(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|synthesis synthesis|amod|END_ENTITY	Heparin suppresses cyclosporine-induced endothelin-1 synthesis in rat endothelial cells .
7509997	0	Heparin	0,7	endothelin-1_and_proto-oncogene_c-fos	17,54	Heparin	endothelin-1 and proto-oncogene c-fos	MESH:D006493	281137(Tax:9913)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Heparin inhibits endothelin-1_and_proto-oncogene_c-fos gene expression in cultured bovine endothelial cells .
9506849	0	Heparin	0,7	ornithine_decarboxylase	39,62	Heparin	ornithine decarboxylase	MESH:D006493	4953	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Heparin inhibits phorbol_ester-induced ornithine_decarboxylase gene expression in endothelial cells .
9352356	0	Heparin_disaccharides	0,21	tumor_necrosis_factor-alpha	30,57	Heparin disaccharides	tumor necrosis factor-alpha	null	7124	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|production production|amod|END_ENTITY	Heparin_disaccharides inhibit tumor_necrosis_factor-alpha production by macrophages and arrest immune inflammation in rodents .
19380872	0	Hepcidin	0,8	alpha-2-macroglobulin	67,88	Hepcidin	alpha-2-macroglobulin	MESH:C428463	232345(Tax:10090)	Chemical	Gene	bound|nsubjpass|START_ENTITY bound|nmod|END_ENTITY	Hepcidin , the hormone of iron metabolism , is bound specifically to alpha-2-macroglobulin in blood .
26676750	0	Herbacetin	0,10	ornithine_decarboxylase	46,69	Herbacetin	ornithine decarboxylase	MESH:C581534	18263(Tax:10090)	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Herbacetin is a novel allosteric inhibitor of ornithine_decarboxylase with antitumor activity .
7556623	0	Herbimycin_A	0,12	JAK2	78,82	Herbimycin A	JAK2	MESH:C020754	3717	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|activation activation|nmod|END_ENTITY	Herbimycin_A suppresses NF-kappa_B activation and tyrosine phosphorylation of JAK2 and the subsequent induction of nitric_oxide synthase in C6 glioma cells .
1544454	0	Herbimycin_A	0,12	NF-kappa_B	33,43	Herbimycin A	NF-kappa B	MESH:C020754	18033(Tax:10090)	Chemical	Gene	blocks|compound|START_ENTITY IL-1-induced|nsubj|blocks IL-1-induced|dobj|activity activity|amod|END_ENTITY	Herbimycin_A blocks IL-1-induced NF-kappa_B DNA-binding activity in lymphoid cell lines .
7556623	0	Herbimycin_A	0,12	NF-kappa_B	24,34	Herbimycin A	NF-kappa B	MESH:C020754	4790	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|activation activation|amod|END_ENTITY	Herbimycin_A suppresses NF-kappa_B activation and tyrosine phosphorylation of JAK2 and the subsequent induction of nitric_oxide synthase in C6 glioma cells .
8514886	0	Herbimycin_A	0,12	pp60c-src	16,25	Herbimycin A	pp60c-src	MESH:C020754	20779(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Herbimycin_A , a pp60c-src tyrosine kinase inhibitor , inhibits osteoclastic bone resorption in vitro and hypercalcemia in vivo .
8797110	0	Herbimycin_A	0,12	tyrosine_kinase	16,31	Herbimycin A	tyrosine kinase	MESH:C020754	7294	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Herbimycin_A , a tyrosine_kinase inhibitor , impairs hypercalcemia associated with a human squamous_cancer producing interleukin-6 in nude_mice .
26442368	0	Heroin	11,17	DLG4	21,25	Heroin	DLG4	MESH:D003932	29495(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|Expression Expression|compound|END_ENTITY	-LSB- Effect of Heroin on DLG4 Expression in Hippocampus , Amygdala and Frontal Cortex of Rats -RSB- .
27072068	0	Heroin	15,21	IL-1	61,65	Heroin	IL-1	MESH:D003932	3552	Chemical	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	Acquisition of Heroin Conditioned Immunosuppression Requires IL-1 Signaling in the Dorsal Hippocampus .
10741899	0	Heroin	0,6	inducible_nitric_oxide_synthase	35,66	Heroin	inducible nitric oxide synthase	MESH:D003932	24599(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	Heroin modulates the expression of inducible_nitric_oxide_synthase .
12707311	0	Hesperadin	19,29	Aurora_B	49,57	Hesperadin	Aurora B	MESH:C474723	9212	Chemical	Gene	reveals|nsubj|START_ENTITY reveals|dobj|role role|nmod|END_ENTITY	The small molecule Hesperadin reveals a role for Aurora_B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint .
24009869	0	Hesperetin	0,10	Cholecystokinin	22,37	Hesperetin	Cholecystokinin	MESH:C013015	885	Chemical	Gene	Secretion|compound|START_ENTITY Secretion|compound|END_ENTITY	Hesperetin Stimulates Cholecystokinin Secretion in Enteroendocrine STC-1 Cells .
23153811	0	Hesperetin	0,10	transforming_growth_factor-b	32,60	Hesperetin	transforming growth factor-b	MESH:C013015	7040	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	Hesperetin : an inhibitor of the transforming_growth_factor-b -LRB- TGF-b -RRB- signaling pathway .
19110045	0	Hesperidin	0,10	matrix_metalloproteinase-9	42,68	Hesperidin	matrix metalloproteinase-9	MESH:D006569	4318	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|dobj|expression expression|amod|END_ENTITY	Hesperidin inhibited acetaldehyde-induced matrix_metalloproteinase-9 gene expression in human hepatocellular_carcinoma cells .
22182498	0	Heteroaromatic-aminomethyl_quinolones	0,37	iNOS	60,64	Heteroaromatic-aminomethyl quinolones	iNOS	null	18126(Tax:10090)	Chemical	Gene	START_ENTITY|dep|inhibitors inhibitors|compound|END_ENTITY	Heteroaromatic-aminomethyl_quinolones : potent and selective iNOS inhibitors .
21801384	0	Heteroarylketones	0,17	interleukin-6	37,50	Heteroarylketones	interleukin-6	null	16193(Tax:10090)	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|expression expression|amod|END_ENTITY	Heteroarylketones inhibit astroglial interleukin-6 expression via a STAT3/NF-kB signaling pathway .
27029998	0	Heterocyclic_Aromatic_Amines	13,41	Bisphenol-A	65,76	Heterocyclic Aromatic Amines	Bisphenol-A	null	667	Chemical	Gene	Level|compound|START_ENTITY Level|nmod|END_ENTITY	Formation of Heterocyclic_Aromatic_Amines and Migration Level of Bisphenol-A in Sous-Vide-Cooked Trout Fillets at Different Cooking Temperatures and Cooking Levels .
17466352	0	Hexachlorobenzene	0,17	CYP1A2	86,92	Hexachlorobenzene	CYP1A2	MESH:D006581	13077(Tax:10090)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|END_ENTITY	Hexachlorobenzene stimulates uroporphyria in low affinity AHR mice without increasing CYP1A2 .
25093615	0	Hexachlorobenzene	0,17	TGF-b1	26,32	Hexachlorobenzene	TGF-b1	MESH:D006581	59086(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Hexachlorobenzene induces TGF-b1 expression , which is a regulator of p27 and cyclin_D1 modifications .
16735606	0	Hexachlorophene	0,15	beta-catenin	77,89	Hexachlorophene	beta-catenin	MESH:D006582	1499	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|promoting promoting|dobj|degradation degradation|amod|END_ENTITY	Hexachlorophene inhibits Wnt/beta-catenin pathway by promoting Siah-mediated beta-catenin degradation .
19091460	0	Hexachlorophene	0,15	beta-catenin	27,39	Hexachlorophene	beta-catenin	MESH:D006582	1499	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Hexachlorophene suppresses beta-catenin expression by up-regulation of Siah-1 in EBV-infected B_lymphoma cells .
19029824	0	Hexamethylene_bisacetamide	0,26	AKT	57,60	Hexamethylene bisacetamide	AKT	MESH:C014026	207	Chemical	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Hexamethylene_bisacetamide -LRB- HMBA -RRB- simultaneously targets AKT and MAPK pathway and represses NF_kappaB activity : implications for cancer therapy .
10450830	0	Hexamethylene_bisacetamide	0,26	thyroglobulin	44,57	Hexamethylene bisacetamide	thyroglobulin	MESH:C014026	21819(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|compound|END_ENTITY	Hexamethylene_bisacetamide -LRB- HMBA -RRB- increases thyroglobulin levels in porcine thyroid cells without increasing cyclic-AMP .
10650339	0	Hexamethylenebisacetamide	0,25	thyroglobulin	40,53	Hexamethylenebisacetamide	thyroglobulin	MESH:C014026	21819(Tax:10090)	Chemical	Gene	modulation|amod|START_ENTITY modulation|nmod|levels levels|compound|END_ENTITY	Hexamethylenebisacetamide modulation of thyroglobulin and protein levels in thyroid cells is not mediated by phosphatidylinositol-3-kinase : a study with wortmannin .
9250581	0	Hexarelin	0,9	GH	61,63	Hexarelin	GH	MESH:C086184	81668(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|appos|END_ENTITY	Hexarelin , a novel GHRP-6 analog , stimulates growth_hormone -LRB- GH -RRB- release in a GH-secreting rat cell line -LRB- GH1 -RRB- insensitive to GH-releasing hormone .
23861368	0	Hexarelin	0,9	ghrelin	28,35	Hexarelin	ghrelin	MESH:C086184	58991(Tax:10090)	Chemical	Gene	treatment|compound|START_ENTITY treatment|nmod|mice mice|compound|END_ENTITY	Hexarelin treatment in male ghrelin knockout mice after myocardial_infarction .
15361691	0	Hexarelin	0,9	growth_hormone	38,52	Hexarelin	growth hormone	MESH:C086184	81668(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|mRNA mRNA|amod|END_ENTITY	Hexarelin modulates the expression of growth_hormone secretagogue receptor type 1a mRNA at hypothalamic and pituitary sites .
8548947	0	Hexarelin	0,9	growth_hormone	18,32	Hexarelin	growth hormone	MESH:C086184	2688	Chemical	Gene	induced|compound|START_ENTITY END_ENTITY|nsubj|induced	Hexarelin induced growth_hormone release is influenced by exogenous growth_hormone .
8548947	0	Hexarelin	0,9	growth_hormone	68,82	Hexarelin	growth hormone	MESH:C086184	2688	Chemical	Gene	induced|compound|START_ENTITY growth_hormone|nsubj|induced growth_hormone|ccomp|influenced influenced|nmod|END_ENTITY	Hexarelin induced growth_hormone release is influenced by exogenous growth_hormone .
8921821	0	Hexarelin	48,57	growth_hormone	109,123	Hexarelin	growth hormone	MESH:C086184	2688	Chemical	Gene	administration|nmod|START_ENTITY desensitize|nsubj|administration desensitize|dobj|responsiveness responsiveness|amod|END_ENTITY	Short-term administration of intranasal or oral Hexarelin , a synthetic hexapeptide , does not desensitize the growth_hormone responsiveness in human aging .
9250581	0	Hexarelin	0,9	growth_hormone	45,59	Hexarelin	growth hormone	MESH:C086184	81668(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|amod|END_ENTITY	Hexarelin , a novel GHRP-6 analog , stimulates growth_hormone -LRB- GH -RRB- release in a GH-secreting rat cell line -LRB- GH1 -RRB- insensitive to GH-releasing hormone .
9534309	0	Hexarelin	0,9	growth_hormone	129,143	Hexarelin	growth hormone	MESH:C086184	81668(Tax:10116)	Chemical	Gene	discloses|nsubj|START_ENTITY discloses|nmod|cardiovascular_damage cardiovascular_damage|nmod|rats rats|nmod|deficiency deficiency|compound|END_ENTITY	Hexarelin , a growth_hormone-releasing_peptide , discloses protectant activity against cardiovascular_damage in rats with isolated growth_hormone deficiency .
7910650	0	Hexarelin	25,34	growth_hormone_releasing_peptide	42,74	Hexarelin	growth hormone releasing peptide	MESH:C086184	51738	Chemical	Gene	activity|nmod|START_ENTITY activity|appos|END_ENTITY	GH-releasing activity of Hexarelin , a new growth_hormone_releasing_peptide , in infant and adult rats .
11564705	0	Hexosamines	0,11	leptin	39,45	Hexosamines	leptin	MESH:D006595	3952	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|production production|compound|END_ENTITY	Hexosamines and nutrient excess induce leptin production and leptin receptor activation in pancreatic_islets and clonal beta-cells .
25240424	0	HgCl2	17,22	CYP1A1	88,94	HgCl2	CYP1A1	MESH:D008627	140634(Tax:7955)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Toxic effects of HgCl2 on activities of SOD , AchE and relative expression of SOD , AChE , CYP1A1 of zebrafish .
6234074	0	HgCl2	0,5	methemoglobin	20,33	HgCl2	methemoglobin	MESH:D008627	3048	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|activity activity|amod|END_ENTITY	HgCl2 increases the methemoglobin prooxidant activity .
17490898	0	HgCl2	11,16	porphobilinogen-synthase	20,44	HgCl2	porphobilinogen-synthase	MESH:D008627	25374(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effects of HgCl2 on porphobilinogen-synthase -LRB- E.C. 4.2.1.24 -RRB- activity and on mercury levels in rats exposed during different precocious periods of postnatal life .
25231763	0	Hh	20,22	Ptc	37,40	Hh	Ptc	null	35851(Tax:7227)	Chemical	Gene	signaling|compound|START_ENTITY signaling|nmod|END_ENTITY	Ihog and Boi elicit Hh signaling via Ptc but do not aid Ptc in sequestering the Hh ligand .
22183510	0	Higenamine	0,10	HMGB1	19,24	Higenamine	HMGB1	MESH:C012348	25459(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	Higenamine reduces HMGB1 during hypoxia-induced brain_injury by induction of heme_oxygenase-1 through PI3K/Akt/Nrf -2 signal pathways .
24557342	0	High	0,4	NHE-1	38,43	High	NHE-1	null	478171(Tax:9615)	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	High glucose concentration stimulates NHE-1 activity in distal nephron cells : the role of the Mek/Erk1/2 / p90RSK and p38MAPK signaling pathways .
24370180	0	Hinokitiol	0,10	ERK	75,78	Hinokitiol	ERK	MESH:C009479	5594	Chemical	Gene	increases|nsubj|START_ENTITY increases|nmod|END_ENTITY	Hinokitiol increases the angiogenic potential of dental pulp cells through ERK and p38MAPK activation and hypoxia-inducible_factor-1a -LRB- HIF-1a -RRB- upregulation .
18537078	0	Hinokitiol	0,10	TNF-alpha	53,62	Hinokitiol	TNF-alpha	MESH:C009479	21926(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Hinokitiol , a natural tropolone derivative , inhibits TNF-alpha production in LPS-activated macrophages via suppression of NF-kappaB .
8652101	0	Hippuryl-L-histidyl-L-leucine	0,29	angiotensin_converting_enzyme	47,76	Hippuryl-L-histidyl-L-leucine	angiotensin converting enzyme	MESH:C010980	1636	Chemical	Gene	START_ENTITY|appos|substrate substrate|nmod|END_ENTITY	Hippuryl-L-histidyl-L-leucine , a substrate for angiotensin_converting_enzyme .
25213146	0	Hirsutenone	0,11	akt	38,41	Hirsutenone	akt	MESH:C508777	207	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	Hirsutenone in Alnus extract inhibits akt activity and suppresses_prostate_cancer cell proliferation .
26331426	0	Hirsutinolide	0,13	Stat3	29,34	Hirsutinolide	Stat3	null	6774	Chemical	Gene	START_ENTITY|dobj|Activity Activity|compound|END_ENTITY	Hirsutinolide Series Inhibit Stat3 Activity , Alter GCN1 , MAP1B , Hsp105 , G6PD , Vimentin , TrxR1 , and Importin a-2 Expression , and Induce Antitumor Effects against Human_Glioma .
7080954	0	His-Phe	10,17	histidine_decarboxylase	46,69	His-Phe	histidine decarboxylase	MESH:C022144	24443(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Effect of His-Phe , a competitive inhibitor of histidine_decarboxylase , on gastric_acid secretion in chronic gastric_fistula rats : delay in acid secretion response to pentagastrin .
26275107	0	Hispidulin	19,29	Pim-1	99,104	Hispidulin	Pim-1	MESH:C055957	5292	Chemical	Gene	Synthesis|nmod|START_ENTITY Synthesis|nmod|END_ENTITY	Total Synthesis of Hispidulin and the Structural Basis for Its Inhibition of Proto-oncogene Kinase Pim-1 .
7248769	0	Histamine	0,9	CA3	46,49	Histamine	CA3	MESH:D006632	761	Chemical	Gene	reactivity|amod|START_ENTITY reactivity|nmod|END_ENTITY	Histamine modulates reactivity of hippocampal CA3 neurons to afferent stimulation in vitro .
14499251	4	Histamine	413,422	CD14	500,504	Histamine	CD14	MESH:D006632	929	Chemical	Gene	decreased|nsubj|START_ENTITY decreased|dobj|expression expression|nmod|END_ENTITY	Histamine concentration - and time-dependently decreased the expression of cell surface CD14 , whereas histamine did not decrease mRNA for CD14 nor increase soluble CD14 -LRB- sCD14 -RRB- .
22394590	0	Histamine	0,9	CD200R1	30,37	Histamine	CD200R1	MESH:D006632	57781(Tax:10090)	Chemical	Gene	release|nsubj|START_ENTITY release|dobj|END_ENTITY	Histamine release and surface CD200R1 staining as sensitive methods for assessing murine mast cell activation .
11342615	0	Histamine	0,9	CD86	18,22	Histamine	CD86	MESH:D006632	942	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Histamine induces CD86 expression and chemokine production by human immature dendritic cells .
1381044	0	Histamine	0,9	Ca2	30,33	Histamine	Ca2	MESH:D006632	760	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|+ +|amod|END_ENTITY	Histamine increases cytosolic Ca2 + in HL-60 promyelocytes predominantly via H2 receptors with an unique agonist/antagonist profile and induces functional differentiation .
18682391	0	Histamine	0,9	Egr-1	18,23	Histamine	Egr-1	MESH:D006632	1958	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Histamine induces Egr-1 expression in human aortic endothelial cells via the H1 receptor-mediated protein kinase Cdelta-dependent ERK activation pathway .
17470620	0	Histamine	0,9	GM-CSF	63,69	Histamine	GM-CSF	MESH:D006632	1437	Chemical	Gene	modulate|nsubj|START_ENTITY modulate|dobj|END_ENTITY	Histamine and tryptase modulate asthmatic airway smooth muscle GM-CSF and RANTES release .
12477078	0	Histamine	0,9	H1_and_H2	109,118	Histamine	H1 and H2	MESH:D006632	3009;6019	Chemical	Gene	release|amod|START_ENTITY release|dep|prophylaxis prophylaxis|nmod|antihistamines antihistamines|amod|END_ENTITY	Histamine release in mesenteric_traction_syndrome during abdominal_aortic_aneurysm surgery : prophylaxis with H1_and_H2 antihistamines .
15986084	0	Histamine	0,9	H1_and_H2	32,41	Histamine	H1 and H2	MESH:D006632	3009;6019	Chemical	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Histamine , histamine receptors -LRB- H1_and_H2 -RRB- , and histidine_decarboxylase expression by chondrocytes of osteoarthritic cartilage : an immunohistochemical study .
11574888	0	Histamine	0,9	H1_and_H2_receptors	80,99	Histamine	H1 and H2 receptors	MESH:D006632	109740(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|expression expression|nmod|END_ENTITY	Histamine regulates T-cell and antibody responses by differential expression of H1_and_H2_receptors .
19913013	0	Histamine	0,9	H1_receptor	20,31	Histamine	H1 receptor	MESH:D006632	3269	Chemical	Gene	acting|advmod|START_ENTITY acting|nmod|END_ENTITY	Histamine acting on H1_receptor promotes inhibition of proliferation via PLC , RAC , and JNK-dependent pathways .
6192308	0	Histamine	0,9	HGT-1	102,107	Histamine	HGT-1	MESH:D006632	8034	Chemical	Gene	interactions|nsubj|START_ENTITY interactions|nmod|END_ENTITY	Histamine and VIP interactions with receptor-cyclic_AMP systems in the human gastric_cancer cell line HGT-1 .
9475663	0	Histamine	0,9	IFN-alpha	30,39	Histamine	IFN-alpha	MESH:D006632	3439	Chemical	Gene	response|amod|START_ENTITY response|nmod|END_ENTITY	Histamine and the response to IFN-alpha in chronic hepatitis_C .
8325995	0	Histamine	0,9	IL-1	46,50	Histamine	IL-1	MESH:D006632	3553	Chemical	Gene	START_ENTITY|dep|induced induced|dobj|expression expression|compound|END_ENTITY	Histamine enhances interleukin -LRB- IL -RRB- -1 - induced IL-1 gene expression and protein synthesis via H2 receptors in peripheral blood mononuclear cells .
10843724	0	Histamine	0,9	IL-18	33,38	Histamine	IL-18	MESH:D006632	3606	Chemical	Gene	inducer|nsubj|START_ENTITY inducer|nmod|END_ENTITY	Histamine is a potent inducer of IL-18 and IFN-gamma in human peripheral blood mononuclear cells .
22389321	0	Histamine	0,9	IL-27	25,30	Histamine	IL-27	MESH:D006632	246778	Chemical	Gene	START_ENTITY|dobj|production production|compound|END_ENTITY	Histamine down-regulates IL-27 production in antigen-presenting cells .
20228932	0	Histamine	27,36	IL-3	11,15	Histamine	IL-3	MESH:D006632	24495(Tax:10116)	Chemical	Gene	Kinetics|compound|START_ENTITY Effects|nmod|Kinetics Effects|nmod|END_ENTITY	Effects of IL-3 and SCF on Histamine Production Kinetics and Cell Phenotype in Rat Bone Marrow-derived Mast Cells .
17276885	0	Histamine	0,9	IL-4	117,121	Histamine	IL-4	MESH:D006632	16189(Tax:10090)	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|phosphorylation phosphorylation|dep|role role|nmod|receptors receptors|nmod|regulation regulation|nmod|production production|compound|END_ENTITY	Histamine affects STAT6 phosphorylation via its effects on IL-4 secretion : role of H1 receptors in the regulation of IL-4 production .
17276885	0	Histamine	0,9	IL-4	59,63	Histamine	IL-4	MESH:D006632	16189(Tax:10090)	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|phosphorylation phosphorylation|nmod|effects effects|nmod|secretion secretion|compound|END_ENTITY	Histamine affects STAT6 phosphorylation via its effects on IL-4 secretion : role of H1 receptors in the regulation of IL-4 production .
18829118	0	Histamine	0,9	IL-4	130,134	Histamine	IL-4	MESH:D006632	100034225(Tax:9796)	Chemical	Gene	bronchoprovocation|amod|START_ENTITY affect|nsubj|bronchoprovocation affect|dobj|expression expression|nmod|END_ENTITY	Histamine bronchoprovocation does not affect bronchoalveolar lavage fluid cytology , gene expression and protein concentrations of IL-4 , IL-8 and IFN-gamma .
7879707	0	Histamine	0,9	IL-5	37,41	Histamine	IL-5	MESH:D006632	3567	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|production production|compound|END_ENTITY	Histamine increases anti-CD3 induced IL-5 production of TH2-type T cells via histamine H2-receptors .
21469095	0	Histamine	0,9	IL-6	56,60	Histamine	IL-6	MESH:D006632	16193(Tax:10090)	Chemical	Gene	activation|compound|START_ENTITY enhances|nsubj|activation enhances|dobj|production production|compound|END_ENTITY	Histamine H receptor activation enhances LPS-induced IL-6 production in mast cells via ERK and PI3K activation .
7511596	0	Histamine	0,9	IL-6	46,50	Histamine	IL-6	MESH:D006632	3569	Chemical	Gene	START_ENTITY|dep|induced induced|dobj|expression expression|compound|END_ENTITY	Histamine enhances interleukin -LRB- IL -RRB- -1 - induced IL-6 gene expression and protein synthesis via H2 receptors in peripheral blood mononuclear cells .
7955543	0	Histamine	0,9	IL-6	18,22	Histamine	IL-6	MESH:D006632	3569	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|compound|END_ENTITY	Histamine induces IL-6 production by human endothelial cells .
9763305	0	Histamine	0,9	IL-6	31,35	Histamine	IL-6	MESH:D006632	3569	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|compound|END_ENTITY	Histamine enhances UVB-induced IL-6 production by human keratinocytes .
24247593	0	Histamine	0,9	IP-10	53,58	Histamine	IP-10	MESH:D006632	3627	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	Histamine downregulates the Th1-associated chemokine IP-10 in monocytes and myeloid dendritic cells .
6205544	0	Histamine	0,9	IgE	108,111	Histamine	IgE	MESH:D006632	3497	Chemical	Gene	release|amod|START_ENTITY release|dep|relationship relationship|nmod|age age|appos|age age|nmod|levels levels|compound|END_ENTITY	Histamine release from whole blood induced by anti-IgE : relationship to patient age , age at onset and serum IgE levels .
11728449	0	Histamine	0,9	LOX-1	38,43	Histamine	LOX-1	MESH:D006632	4973	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Histamine increases the expression of LOX-1 via H2 receptor in human monocytic THP-1 cells .
1370686	2	Histamine	321,330	MCAF	342,346	Histamine	MCAF	MESH:D006632	6347	Chemical	Gene	release|compound|START_ENTITY release|nmod|END_ENTITY	The peak of activity was reached at 10 -LRB- -7 -RRB- M. Histamine release by MCAF was rapid with an initial rate comparable with histamine release by an optimal dose of anti-IgE .
4126255	0	Histamine	0,9	MCDP	21,25	Histamine	MCDP	MESH:D006632	406134(Tax:7460)	Chemical	Gene	release|nsubj|START_ENTITY release|nmod|END_ENTITY	Histamine release by MCDP -LRB- 401 -RRB- , a peptide from the venom of the honey_bee .
17622767	0	Histamine	0,9	MUC5AC	18,24	Histamine	MUC5AC	MESH:D006632	4586	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nummod|END_ENTITY	Histamine induces MUC5AC expression via a hCLCA1 pathway .
7631812	3	Histamine	424,433	NCA	487,490	Histamine	NCA	MESH:D006632	1089	Chemical	Gene	induced|nsubj|START_ENTITY induced|dobj|release release|nmod|END_ENTITY	Histamine weakly but significantly induced the release of both NCA and MCA in a similar fashion .
22674155	0	Histamine	0,9	RANKL	35,40	Histamine	RANKL	MESH:D006632	8600	Chemical	Gene	contributes|nsubj|START_ENTITY contributes|nmod|END_ENTITY	Histamine contributes to increased RANKL to osteoprotegerin ratio through altered nuclear receptor 4A activity in human chondrocytes .
8240385	0	Histamine	0,9	SSAO	72,76	Histamine	SSAO	MESH:D006632	29473(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Histamine lipolytic activity and semicarbazide-sensitive amine oxidase -LRB- SSAO -RRB- of rat white_adipose_tissue -LRB- WAT -RRB- .
21418040	0	Histamine	0,9	TLR2	47,51	Histamine	TLR2	MESH:D006632	7097	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|nmod|END_ENTITY	Histamine promotes the expression of receptors TLR2 and TLR4 and amplifies sensitivity to lipopolysaccharide and lipoteichoic_acid treatment in human gingival fibroblasts .
24709960	0	Histamine	40,49	TRPC6	69,74	Histamine	TRPC6	MESH:D006632	22068(Tax:10090)	Chemical	Gene	Activity|compound|START_ENTITY Activity|compound|END_ENTITY	PKC-dependent Phosphorylation of the H1 Histamine Receptor Modulates TRPC6 Activity .
11306965	0	Histamine	0,9	Th1	22,25	Histamine	Th1	MESH:D006632	51497	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	Histamine upregulates Th1 and downregulates Th2 responses due to different patterns of surface histamine 1 and 2 receptor expression .
15379983	0	Histamine	0,9	Toll-like_receptor_2_and_4	18,44	Histamine	Toll-like receptor 2 and 4	MESH:D006632	7097;7099	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Histamine induces Toll-like_receptor_2_and_4 expression in endothelial cells and enhances sensitivity to Gram-positive and Gram-negative bacterial cell wall components .
8859220	0	Histamine	0,9	VCAM-1	19,25	Histamine	VCAM-1	MESH:D006632	7412	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Histamine augments VCAM-1 expression on IL-4 - _ and_TNF-alpha-stimulated human umbilical vein endothelial cells .
9003354	0	Histamine	0,9	ZO-1	18,22	Histamine	ZO-1	MESH:D006632	7082	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|iobj|END_ENTITY	Histamine reduces ZO-1 tight-junction protein expression in cultured retinal microvascular endothelial cells .
25781725	0	Histamine	0,9	aquaporin_5	24,35	Histamine	aquaporin 5	MESH:D006632	362	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	Histamine downregulates aquaporin_5 in human nasal epithelial cells .
1695464	0	Histamine	0,9	bradykinin	52,62	Histamine	bradykinin	MESH:D006632	3827	Chemical	Gene	secretion|amod|START_ENTITY stimulated|nsubj|secretion stimulated|nmod|END_ENTITY	Histamine secretion from mast cells stimulated with bradykinin .
8275963	0	Histamine	0,9	c-fos	21,26	Histamine	c-fos	MESH:D006632	2353	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Histamine stimulates c-fos expression in hypothalamic vasopressin - , _ oxytocin - , _ and_corticotropin-releasing_hormone-containing neurons .
9187264	0	Histamine	0,9	c-fos	38,43	Histamine	c-fos	MESH:D006632	2353	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	Histamine modulates the expression of c-fos through cyclic_AMP production via the H2 receptor in the human promonocytic cell line U937 .
1331840	0	Histamine	0,9	corticotropin-releasing_hormone	83,114	Histamine	corticotropin-releasing hormone	MESH:D006632	81648(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY secretion|dep|involvement involvement|nmod|END_ENTITY	Histamine - and stress-induced secretion of ACTH and beta-endorphin : involvement of corticotropin-releasing_hormone and vasopressin .
21605904	0	Histamine	0,9	cyclooxygenase_2	20,36	Histamine	cyclooxygenase 2	MESH:D006632	5743	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|amod|END_ENTITY	Histamine regulates cyclooxygenase_2 gene activation through Orai1-mediated NFkB activation in lung_cancer cells .
6428188	0	Histamine	0,9	diamine_oxidase	19,34	Histamine	diamine oxidase	MESH:D006632	26	Chemical	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Histamine content , diamine_oxidase activity and histamine methyltransferase activity in human tissues : fact or fictions ?
18339882	0	Histamine	0,9	fibulin-5_and_insulin-like_growth_factor-II_receptor	21,73	Histamine	fibulin-5 and insulin-like growth factor-II receptor	MESH:D006632	23876;16004	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Histamine suppresses fibulin-5_and_insulin-like_growth_factor-II_receptor expression in melanoma .
2487969	0	Histamine	0,9	gastrin	44,51	Histamine	gastrin	MESH:D006632	25320(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY synthesis|nmod|END_ENTITY	Histamine synthesis after administration of gastrin and blockade of acid secretion in the rat stomach .
6134446	0	Histamine	0,9	gastrin	81,88	Histamine	gastrin	MESH:D006632	100685087	Chemical	Gene	able|nsubj|START_ENTITY able|xcomp|suppress suppress|dobj|effect effect|nmod|somatostatin somatostatin|nmod|END_ENTITY	Histamine is able to suppress the inhibitory effect of somatostatin on exogenous gastrin : comparison between extractive antral_histamine and synthetic histamine .
23791559	0	Histamine	0,9	glutamate_transporter_1	34,57	Histamine	glutamate transporter 1	MESH:D006632	29482(Tax:10116)	Chemical	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|END_ENTITY	Histamine up-regulates astrocytic glutamate_transporter_1 and protects neurons against ischemic_injury .
7789322	0	Histamine	0,9	gonadotropin-releasing_hormone	30,60	Histamine	gonadotropin-releasing hormone	MESH:D006632	2796	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|amod|END_ENTITY	Histamine directly stimulates gonadotropin-releasing_hormone secretion from GT1-1 cells via H1 receptors coupled to phosphoinositide hydrolysis .
23932072	0	Histamine	0,9	histamine_4_receptor	98,118	Histamine	histamine 4 receptor	MESH:D006632	59340	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Histamine induces proliferation in keratinocytes from patients with atopic_dermatitis through the histamine_4_receptor .
2442980	0	Histamine	0,9	histamine_releasing_factor	64,90	Histamine	histamine releasing factor	MESH:D006632	7178	Chemical	Gene	release|amod|START_ENTITY induced|nsubj|release induced|nmod|END_ENTITY	Histamine release from mast cells of various species induced by histamine_releasing_factor from human lymphocytes .
11718724	0	Histamine	0,9	histidine_decarboxylase	100,123	Histamine	histidine decarboxylase	MESH:D006632	15186(Tax:10090)	Chemical	Gene	deficiency|amod|START_ENTITY induces|nsubj|deficiency induces|nmod|mice mice|amod|END_ENTITY	Histamine deficiency induces tissue-specific down-regulation of histamine H2 receptor expression in histidine_decarboxylase knockout mice .
15099528	0	Histamine	0,9	histidine_decarboxylase	60,83	Histamine	histidine decarboxylase	MESH:D006632	15186(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY production|nmod|induction induction|nmod|END_ENTITY	Histamine production via mast cell-independent induction of histidine_decarboxylase in response to lipopolysaccharide and interleukin-1 .
16790022	0	Histamine	0,9	histidine_decarboxylase	66,89	Histamine	histidine decarboxylase	MESH:D006632	3067	Chemical	Gene	mediated|dep|START_ENTITY regulation|amod|mediated regulation|nmod|gene gene|amod|END_ENTITY	Histamine , histidine , and growth-phase mediated regulation of the histidine_decarboxylase gene in lactic_acid bacteria isolated from wine .
21618884	0	Histamine	0,9	histidine_decarboxylase	45,68	Histamine	histidine decarboxylase	MESH:D006632	15186(Tax:10090)	Chemical	Gene	synthesis|amod|START_ENTITY learned|nsubj|synthesis learned|nmod|mice mice|amod|END_ENTITY	Histamine synthesis and lessons learned from histidine_decarboxylase deficient mice .
21710252	0	Histamine	0,9	histidine_decarboxylase	69,92	Histamine	histidine decarboxylase	MESH:D006632	15186(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY expression|appos|plasticity plasticity|nmod|mice mice|amod|END_ENTITY	Histamine receptor expression , hippocampal plasticity and ammonia in histidine_decarboxylase knockout mice .
21713686	0	Histamine	0,9	histidine_decarboxylase	45,68	Histamine	histidine decarboxylase	MESH:D006632	15186(Tax:10090)	Chemical	Gene	synthesis|amod|START_ENTITY learned|nsubj|synthesis learned|nmod|mice mice|amod|END_ENTITY	Histamine synthesis and lessons learned from histidine_decarboxylase deficient mice .
2616033	0	Histamine	0,9	histidine_decarboxylase	69,92	Histamine	histidine decarboxylase	MESH:D006632	24443(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY regulated|nsubjpass|synthesis regulated|nmod|END_ENTITY	Histamine synthesis in rat hypothalamus is not acutely regulated via histidine_decarboxylase .
2784410	0	Histamine	0,9	histidine_decarboxylase	59,82	Histamine	histidine decarboxylase	MESH:D006632	15186(Tax:10090)	Chemical	Gene	synthesis|amod|START_ENTITY lymphocytes|nsubj|synthesis lymphocytes|nmod|END_ENTITY	Histamine synthesis by mouse T lymphocytes through induced histidine_decarboxylase .
3111193	0	Histamine	0,9	histidine_decarboxylase	33,56	Histamine	histidine decarboxylase	MESH:D006632	3067	Chemical	Gene	levels|amod|START_ENTITY levels|nmod|END_ENTITY	Histamine levels and activity of histidine_decarboxylase -LRB- HD -RRB- and histamine-methyltransferase -LRB- HMT -RRB- in neonate and adult human brain .
3263312	0	Histamine	0,9	histidine_decarboxylase	77,100	Histamine	histidine decarboxylase	MESH:D006632	15186(Tax:10090)	Chemical	Gene	synthesis|nsubj|START_ENTITY synthesis|nmod|induction induction|nmod|END_ENTITY	Histamine synthesis by non-mast cells through mitogen-dependent induction of histidine_decarboxylase .
6017372	0	Histamine	0,9	histidine_decarboxylase	21,44	Histamine	histidine decarboxylase	MESH:D006632	3067	Chemical	Gene	formation|amod|START_ENTITY formation|dep|determination determination|amod|END_ENTITY	Histamine formation : histidine_decarboxylase determination using carboxyl-14-C-labeled histidine .
871094	0	Histamine	0,9	histidine_decarboxylase	143,166	Histamine	histidine decarboxylase	MESH:D006632	24443(Tax:10116)	Chemical	Gene	haemorrhagic_lesions|amod|START_ENTITY haemorrhagic_lesions|dep|catechin catechin|appos|inhibitor inhibitor|nmod|END_ENTITY	Histamine and acute haemorrhagic_lesions in rat gastric mucosa : prevention of stress ulcer formation by -LRB- + -RRB- - catechin , an inhibitor of specific histidine_decarboxylase in vitro .
11752121	0	Histamine	0,9	intercellular_adhesion_molecule-1	105,138	Histamine	intercellular adhesion molecule-1	MESH:D006632	3383	Chemical	Gene	regulation|amod|START_ENTITY associated|nsubjpass|regulation associated|nmod|down-regulation down-regulation|nmod|expression expression|amod|END_ENTITY	Histamine regulation of interleukin-18-initiating cytokine cascade is associated with down-regulation of intercellular_adhesion_molecule-1 expression in human peripheral blood mononuclear cells .
8102141	0	Histamine	0,9	intercellular_adhesion_molecule-1	103,136	Histamine	intercellular adhesion molecule-1	MESH:D006632	3383	Chemical	Gene	tumor_necrosis_factor-alpha|amod|START_ENTITY mediated|nsubj|tumor_necrosis_factor-alpha mediated|dobj|induction induction|nmod|expression expression|amod|END_ENTITY	Histamine and cis-urocanic_acid augment tumor_necrosis_factor-alpha mediated induction of keratinocyte intercellular_adhesion_molecule-1 expression .
2944612	0	Histamine	0,9	interferon-gamma	19,35	Histamine	interferon-gamma	MESH:D006632	3458	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Histamine inhibits interferon-gamma production via suppression of interleukin_2 synthesis .
3939107	0	Histamine	0,9	interferon-gamma	38,54	Histamine	interferon-gamma	MESH:D006632	3458	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|production production|nmod|END_ENTITY	Histamine modulates the production of interferon-gamma and interleukin-2 by mitogen-activated human mononuclear blood cells .
10569698	0	Histamine	0,9	interferon_gamma	88,104	Histamine	interferon gamma	MESH:D006632	3458	Chemical	Gene	antagonists|amod|START_ENTITY modify|nsubj|antagonists modify|dobj|expression expression|nmod|END_ENTITY	Histamine and histamine-receptor antagonists modify gene expression and biosynthesis of interferon_gamma in peripheral human blood mononuclear cells and in CD19-depleted cell subsets .
9569243	0	Histamine	0,9	interleukin-4	18,31	Histamine	interleukin-4	MESH:D006632	3565	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|END_ENTITY	Histamine affects interleukin-4 , interleukin-5 , and interferon-gamma production by human T cell clones from the airways and blood .
17122961	0	Histamine	0,9	interleukin-6	18,31	Histamine	interleukin-6	MESH:D006632	3569	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Histamine induces interleukin-6 expression in the human synovial_sarcoma cell line -LRB- SW982 -RRB- through the H1 receptor .
19907186	0	Histamine	0,9	interleukin-6	21,34	Histamine	interleukin-6	MESH:D006632	3569	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|amod|END_ENTITY	Histamine stimulates interleukin-6 production through histamine H1 receptors in human amnion cells .
2897711	0	Histamine	0,9	interleukin_1	19,32	Histamine	interleukin 1	MESH:D006632	3552	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Histamine inhibits interleukin_1 production by lipopolysaccharide-stimulated human peripheral blood monocytes .
22582780	0	Histamine	0,9	mucin	20,25	Histamine	mucin	MESH:D006632	100508689	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Histamine regulates mucin expression through H1 receptor in airway epithelial cells .
6174350	0	Histamine	0,9	neurotensin	29,40	Histamine	neurotensin	MESH:D006632	299757(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY induced|nsubj|release induced|nmod|END_ENTITY	Histamine release induced by neurotensin from rat peritoneal mast cells .
6208534	0	Histamine	0,9	neurotensin	21,32	Histamine	neurotensin	MESH:D006632	299757(Tax:10116)	Chemical	Gene	release|nsubj|START_ENTITY release|nmod|END_ENTITY	Histamine release by neurotensin in the rat hindquarter : structure-activity studies .
2323037	0	Histamine	0,9	ornithine_decarboxylase	20,43	Histamine	ornithine decarboxylase	MESH:D006632	4953	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|activity activity|amod|END_ENTITY	Histamine increases ornithine_decarboxylase activity in primary cultures of cerebellar granule cells .
2450844	0	Histamine	0,9	platelet-activating_factor	43,69	Histamine	platelet-activating factor	MESH:D006632	9768	Chemical	Gene	release|nsubj|START_ENTITY release|nmod|END_ENTITY	Histamine release from human leukocytes by platelet-activating_factor .
2889511	0	Histamine	0,9	prolactin	65,74	Histamine	prolactin	MESH:D006632	24683(Tax:10116)	Chemical	Gene	sites|amod|START_ENTITY sites|dep|role role|nmod|release release|compound|END_ENTITY	Histamine sensitive sites in hippocampus : their probable role on prolactin release in male rats .
580536	0	Histamine	0,9	prolactin	21,30	Histamine	prolactin	MESH:D006632	5617	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|compound|END_ENTITY	Histamine stimulates prolactin release in norman men .
7921229	0	Histamine	0,9	prolactin	30,39	Histamine	prolactin	MESH:D006632	24683(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY secretion|compound|END_ENTITY	Histamine - and stress-induced prolactin secretion : importance of vasopressin V1 - and V2-receptors .
20435034	0	Histamine	0,9	substance_P	89,100	Histamine	substance P	MESH:D006632	21333(Tax:10090)	Chemical	Gene	potentiates|amod|START_ENTITY potentiates|dep|role role|compound|END_ENTITY	Histamine H3 receptor activation potentiates peripheral opioid-mediated antinociception : substance_P role in peripheral inflammation in mice .
2425383	0	Histamine	0,9	substance_P	63,74	Histamine	substance P	MESH:D006632	6863	Chemical	Gene	release|amod|START_ENTITY release|nmod|tachykinins tachykinins|compound|END_ENTITY	Histamine release and local responses of rat and human skin to substance_P and other mammalian tachykinins .
2427144	0	Histamine	0,9	substance_P	35,46	Histamine	substance P	MESH:D006632	6863	Chemical	Gene	released|nsubjpass|START_ENTITY released|nmod|END_ENTITY	Histamine is released from skin by substance_P but does not act as the final vasodilator in the axon reflex .
6187030	0	Histamine	0,9	substance_P	37,48	Histamine	substance P	MESH:D006632	6863	Chemical	Gene	release|nsubj|START_ENTITY release|nmod|sequences sequences|compound|END_ENTITY	Histamine release from mast cells by substance_P and substance_P sequences .
12646554	0	Histamine	0,9	tumor_necrosis_factor	22,43	Histamine	tumor necrosis factor	MESH:D006632	7124	Chemical	Gene	antagonizes|nsubj|START_ENTITY antagonizes|dobj|END_ENTITY	Histamine antagonizes tumor_necrosis_factor -LRB- TNF -RRB- signaling by stimulating TNF receptor shedding from the cell surface and Golgi storage pool .
2056280	0	Histamine	0,9	tumor_necrosis_factor_alpha	54,81	Histamine	tumor necrosis factor alpha	MESH:D006632	7124	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|nmod|END_ENTITY	Histamine suppresses gene expression and synthesis of tumor_necrosis_factor_alpha via histamine H2 receptors .
8652190	0	Histamine	0,9	tumor_necrosis_factor_alpha	19,46	Histamine	tumor necrosis factor alpha	MESH:D006632	24835(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|compound|END_ENTITY	Histamine inhibits tumor_necrosis_factor_alpha release by mast cells through H2 and H3 receptors .
17635071	0	Histamine	0,9	uncoupling_protein_2	36,56	Histamine	uncoupling protein 2	MESH:D006632	22228(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Histamine induces the expression of uncoupling_protein_2 -LRB- UCP2 -RRB- and acid-binding_protein -LRB- aP2 -RRB- in white adipocytes .
27046830	0	Histidine	9,18	CKI1	4,8	Histidine	CKI1	CHEBI:27570	819356(Tax:3702)	Chemical	Gene	Kinase|compound|START_ENTITY Kinase|compound|END_ENTITY	The CKI1 Histidine Kinase Specifies the Female Gametic Precursor of the Endosperm .
22467798	0	Histidine	0,9	ETR1	51,55	Histidine	ETR1	CHEBI:27570	842951(Tax:3702)	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Histidine kinase activity of the ethylene receptor ETR1 facilitates the ethylene response in Arabidopsis .
9636235	0	Histidine	0,9	ETR1	33,37	Histidine	ETR1	CHEBI:27570	842951(Tax:3702)	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|dobj|activity activity|nmod|receptor receptor|compound|END_ENTITY	Histidine kinase activity of the ETR1 ethylene receptor from Arabidopsis .
16719907	0	Histidine	50,59	FHIT	67,71	Histidine	FHIT	CHEBI:27570	692183(Tax:9913)	Chemical	Gene	Triad|compound|START_ENTITY mapping|nmod|Triad mapping|appos|END_ENTITY	Comparative genomic mapping of the bovine Fragile Histidine Triad -LRB- FHIT -RRB- tumour suppressor gene : characterization of a 2 Mb BAC contig covering the locus , complete annotation of the gene , analysis of cDNA and of physiological expression profiles .
25451928	0	Histidine	119,128	Myoglobin	49,58	Histidine	Myoglobin	CHEBI:27570	102975021	Chemical	Gene	Mimic|nmod|START_ENTITY Engineered|acl|Mimic Engineered|compound|END_ENTITY	Significantly Enhanced Heme Retention Ability of Myoglobin Engineered to Mimic the Third Covalent Linkage by Non-Axial Histidine to Heme -LRB- Vinyl -RRB- in Synechocystis Hemoglobin .
7543025	0	Histidine	0,9	P-selectin	29,39	Histidine	P-selectin	CHEBI:27570	6403	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Histidine phosphorylation of P-selectin upon stimulation of human platelets : a novel pathway for activation-dependent signal transduction .
24865971	0	Histidine	0,9	Rpl3p	49,54	Histidine	Rpl3p	CHEBI:27570	854229(Tax:4932)	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	Histidine methylation of yeast ribosomal protein Rpl3p is required for proper 60S subunit assembly .
3126084	0	Histidine	0,9	carbonic_anhydrase_II	70,91	Histidine	carbonic anhydrase II	CHEBI:27570	760	Chemical	Gene	required|nsubjpass|START_ENTITY required|nmod|activity activity|nmod|END_ENTITY	Histidine 64 is not required for high CO2 hydration activity of human carbonic_anhydrase_II .
9398308	0	Histidine	0,9	carbonic_anhydrase_II	75,96	Histidine	carbonic anhydrase II	CHEBI:27570	760	Chemical	Gene	START_ENTITY|dep|substitutions substitutions|nmod|site site|nmod|END_ENTITY	Histidine -- > carboxamide ligand substitutions in the zinc binding site of carbonic_anhydrase_II alter metal coordination geometry but retain catalytic activity .
17701542	0	Histidine	0,9	myoglobin	106,115	Histidine	myoglobin	CHEBI:27570	102975021	Chemical	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	Histidine and not tyrosine is required for the peroxide-induced formation of haem to protein cross-linked myoglobin .
7999129	0	Histidyl	0,8	P36	28,31	Histidyl	P36	CHEBI:37906	56611(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Histidyl phosphorylation of P36 in rat hepatoma Fao cells in vitro and in vivo .
3088606	0	Histidyl-proline	0,16	thyrotropin_releasing_hormone	51,80	Histidyl-proline	thyrotropin releasing hormone	MESH:C035699	25569(Tax:10116)	Chemical	Gene	START_ENTITY|appos|metabolite metabolite|nmod|END_ENTITY	Histidyl-proline , a rapidly degraded metabolite of thyrotropin_releasing_hormone , has behavioural activity .
19172749	0	Histone_chaperone	0,17	Rtt109	33,39	Histone chaperone	Rtt109	null	850658(Tax:4932)	Chemical	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Histone_chaperone specificity in Rtt109 activation .
3790371	0	Histydyl-proline_diketopiperazine	1,34	thyrotropin-releasing_hormone	58,87	Histydyl-proline diketopiperazine	thyrotropin-releasing hormone	null	25569(Tax:10116)	Chemical	Gene	START_ENTITY|appos|metabolite metabolite|nmod|END_ENTITY	-LSB- Histydyl-proline_diketopiperazine -LRB- HPD -RRB- , a metabolite of thyrotropin-releasing_hormone -LRB- TRH -RRB- , improves the ataxic gait in 3-acetylpyridine -LRB- 3-AP -RRB- treated rats -RSB- .
17306151	0	Ho-MTHFR	142,150	methylenetetrahydrofolate_reductase	100,135	Ho-MTHFR	methylenetetrahydrofolate reductase	null	4524	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Clinical comments on genetic marker prevalence -LRB- factor_V_Leiden , prothrombin 20210A and homozygous methylenetetrahydrofolate_reductase form -LSB- Ho-MTHFR -RSB- -RRB- : based on a study conducted in Health Department No. 19 of the Valencian Community -RSB- .
6820372	0	Hoe-766	121,128	LHRH	107,111	Hoe-766	LHRH	MESH:D002064	2796	Chemical	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	Sensitivity of luteinizing hormone and gonadal steroid responses to single intranasal administration of an LHRH agonist -LRB- Hoe-766 -RRB- in young normal adult men .
11139431	0	Hoe_140	78,85	bradykinin	41,51	Hoe 140	bradykinin	MESH:C065679	3827	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	In various tumour cell lines the peptide bradykinin B -LRB- 2 -RRB- receptor antagonist , Hoe_140 -LRB- Icatibant -RRB- , may act as mitogenic agonist .
11972749	0	Hoe_140	111,118	bradykinin	69,79	Hoe 140	bradykinin	MESH:C065679	3827	Chemical	Gene	antagonist|dobj|START_ENTITY antagonist|nsubj|Synthesis Synthesis|nmod|derivatives derivatives|nmod|receptor receptor|compound|END_ENTITY	Synthesis and analysis of potent , more lipophilic derivatives of the bradykinin B2 receptor antagonist peptide Hoe_140 .
8032609	8	Hoe_140	949,956	bradykinin	959,969	Hoe 140	bradykinin	MESH:C065679	3827	Chemical	Gene	des-Arg9-bradykinin|compound|START_ENTITY des-Arg9-bradykinin|compound|END_ENTITY	In both healthy and squamous-carcinoma preparations , bradykinin analogues displace -LSB- 3H -RSB- - bradykinin binding with the following relative order of potency : Hoe_140 > bradykinin > kallidin > D-Arg0 -LSB- Hyp3,D-Phe7 -RSB- bradykinin > des-Arg9-bradykinin .
8319757	0	Hoe_140	22,29	bradykinin	58,68	Hoe 140	bradykinin	MESH:C065679	3827	Chemical	Gene	effects|nmod|START_ENTITY effects|acl|END_ENTITY	Inhibitory effects of Hoe_140 on vasodilator responses to bradykinin in the mesenteric vascular bed of the cat .
8876263	0	Hoe_140	55,62	bradykinin	14,24	Hoe 140	bradykinin	MESH:C065679	3827	Chemical	Gene	antagonist|dobj|START_ENTITY antagonist|nsubj|effect effect|nmod|END_ENTITY	The effect of bradykinin and the bradykinin antagonist Hoe_140 on kinematic parameters of human spermatozoa .
8922758	0	Hoe_140	98,105	bradykinin	24,34	Hoe 140	bradykinin	MESH:C065679	3827	Chemical	Gene	-RSB-|dep|START_ENTITY the|nmod|-RSB- using|dobj|the airway|xcomp|using airway|nsubj|Characterization Characterization|nmod|receptor receptor|compound|END_ENTITY	Characterization of the bradykinin receptor in the human nasal airway using the binding of -LSB- 125I -RSB- - Hoe_140 .
6097272	0	Hoe_498	188,195	angiotensin_converting_enzyme	38,67	Hoe 498	angiotensin converting enzyme	MESH:D017257	1636	Chemical	Gene	Tolerance|dep|START_ENTITY Tolerance|nmod|inhibitor inhibitor|amod|END_ENTITY	Tolerance and pharmacodynamics of the angiotensin_converting_enzyme inhibitor 2 - -LSB- N - -LSB- -LRB- S -RRB- -1 - ethoxycarbonyl-3-phenylpropyl -RSB- - L-alanyl -RSB- - -LRB- 1S ,3 S ,5 S -RRB- -2 - _ azabicyclo -LSB- 3.3.0 -RSB- octane-3-carboxylic_acid -LRB- Hoe_498 -RRB- in healthy volunteers .
9105411	0	Hoechst_33342	23,36	P-glycoprotein	77,91	Hoechst 33342	P-glycoprotein	MESH:C017807	5243	Chemical	Gene	transport|amod|START_ENTITY Effect|nmod|transport Effect|nmod|END_ENTITY	Effect of quercetin on Hoechst_33342 transport by purified and reconstituted P-glycoprotein .
15704253	0	Homocysteine	0,12	C-reactive_protein	28,46	Homocysteine	C-reactive protein	MESH:D006710	1401	Chemical	Gene	START_ENTITY|nmod|cholesterol cholesterol|compound|END_ENTITY	Homocysteine in relation to C-reactive_protein and low-density lipoprotein cholesterol in assessment of cardiovascular risk .
23485152	0	Homocysteine	0,12	COX-2	21,26	Homocysteine	COX-2	MESH:D006710	17709(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Homocysteine induces COX-2 expression in macrophages through ROS generated by NMDA receptor-calcium signaling pathways .
18237028	0	Homocysteine	0,12	GPx-1	57,62	Homocysteine	GPx-1	MESH:D006710	2876	Chemical	Gene	START_ENTITY|nmod|activity activity|appos|END_ENTITY	Homocysteine effects on cellular_glutathione_peroxidase -LRB- GPx-1 -RRB- activity under in vitro conditions .
17020760	0	Homocysteine	0,12	Herp	37,41	Homocysteine	Herp	MESH:D006710	9709	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Homocysteine regulates expression of Herp by DNA methylation involving the AARE and CREB binding sites .
25982096	0	Homocysteine	0,12	LOX-1	25,30	Homocysteine	LOX-1	MESH:D006710	4973	Chemical	Gene	activation|amod|START_ENTITY activation|compound|END_ENTITY	Homocysteine facilitates LOX-1 activation and endothelial death through the PKCb and SIRT1/HSF1 mechanism : relevance to human hyperhomocysteinaemia .
25982096	0	Homocysteine	0,12	LOX-1	25,30	Homocysteine	LOX-1	MESH:D006710	4973	Chemical	Gene	activation|amod|START_ENTITY activation|compound|END_ENTITY	Homocysteine facilitates LOX-1 activation and endothelial death through the PKCb and SIRT1/HSF1 mechanism : relevance to human hyperhomocysteinaemia .
22326992	0	Homocysteine	0,12	MMP-9	22,27	Homocysteine	MMP-9	MESH:D006710	17395(Tax:10090)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|compound|END_ENTITY	Homocysteine enhances MMP-9 production in murine macrophages via ERK and Akt signaling pathways .
16144556	0	Homocysteine	0,12	MTHFR	14,19	Homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	START_ENTITY|appos|polymorphism polymorphism|compound|END_ENTITY	Homocysteine , MTHFR C677T gene polymorphism , folic_acid and vitamin_B 12 in patients with retinal_vein_occlusion .
16244782	0	Homocysteine	0,12	MTHFR	40,45	Homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	levels|amod|START_ENTITY associated|nsubjpass|levels associated|nmod|polymorphism polymorphism|compound|END_ENTITY	Homocysteine levels are associated with MTHFR A1298C polymorphism in Indian population .
18670064	0	Homocysteine	0,12	MTHFR	14,19	Homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	START_ENTITY|appos|polymorphisms polymorphisms|amod|END_ENTITY	Homocysteine , MTHFR gene polymorphisms , and cardio-cerebrovascular risk .
19793004	0	Homocysteine	0,12	MTHFR	114,119	Homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	levels|amod|START_ENTITY associated|nsubjpass|levels associated|nmod|cervical_cancer cervical_cancer|nmod|polymorphisms polymorphisms|appos|END_ENTITY	Homocysteine levels are associated with cervical_cancer independent of methylene_tetrahydrofolate reductase gene -LRB- MTHFR -RRB- polymorphisms in Indian population .
20890573	0	Homocysteine	1,13	MTHFR	42,47	Homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	levels|compound|START_ENTITY levels|nmod|genes genes|compound|END_ENTITY	-LSB- Homocysteine levels and polymorphisms of MTHFR and CBS genes in Colombian patients with superficial and deep_venous_thrombosis -RSB- .
22363213	0	Homocysteine	0,12	MTHFR	58,63	Homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	START_ENTITY|dep|meta-analysis meta-analysis|nmod|studies studies|amod|END_ENTITY	Homocysteine and coronary_heart_disease : meta-analysis of MTHFR case-control studies , avoiding publication bias .
24532985	0	Homocysteine	0,12	MTHFR	81,86	Homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	START_ENTITY|nmod|Related Related|nmod|END_ENTITY	Homocysteine Level and Mechanisms_of_Injury in Parkinson 's _ Disease as Related to MTHFR , MTR , and MTHFD1 Genes Polymorphisms and L-Dopa Treatment .
25115547	0	Homocysteine	0,12	MTHFR	49,54	Homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	levels|amod|START_ENTITY modulated|nsubjpass|levels modulated|nmod|polymorphism polymorphism|compound|END_ENTITY	Homocysteine and nitrite levels are modulated by MTHFR 677C > T polymorphism in obese women treated with simvastatin .
25297611	0	Homocysteine	154,166	MTHFR	93,98	Homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	Levels|nmod|START_ENTITY Genotype|nmod|Levels Genotype|nsubj|Study Study|acl|Find Find|dobj|Relationship Relationship|nmod|C677T C677T|appos|END_ENTITY	A Cross-Sectional Study to Find Out the Relationship of Methylenetetrahydrofolate_Reductase -LRB- MTHFR -RRB- C677T Genotype with Plasma Levels of Folate and Total Homocysteine by Daily Folate Intake in Japanese .
26266420	0	Homocysteine	0,12	MTHFR	44,49	Homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	Jointly|compound|START_ENTITY Jointly|dep|C677T C677T|compound|END_ENTITY	Homocysteine Metabolism Gene Polymorphisms -LRB- MTHFR C677T , MTHFR A1298C , MTR A2756G and MTRR A66G -RRB- Jointly Elevate the Risk of Folate_Deficiency .
25297611	0	Homocysteine	154,166	Methylenetetrahydrofolate_Reductase	56,91	Homocysteine	Methylenetetrahydrofolate Reductase	MESH:D006710	4524	Chemical	Gene	Levels|nmod|START_ENTITY Genotype|nmod|Levels Genotype|nsubj|Study Study|acl|Find Find|dobj|Relationship Relationship|nmod|C677T C677T|compound|END_ENTITY	A Cross-Sectional Study to Find Out the Relationship of Methylenetetrahydrofolate_Reductase -LRB- MTHFR -RRB- C677T Genotype with Plasma Levels of Folate and Total Homocysteine by Daily Folate Intake in Japanese .
23567851	0	Homocysteine	0,12	Nrf2	74,78	Homocysteine	Nrf2	MESH:D006710	4780	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Homocysteine induces heme_oxygenase-1 expression via transcription factor Nrf2 activation in HepG2 cell .
12631082	0	Homocysteine	0,12	TIMP-1	22,28	Homocysteine	TIMP-1	MESH:D006710	116510(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	Homocysteine enhances TIMP-1 expression and cell proliferation associated with NADH oxidase in rat mesangial cells .
17586618	0	Homocysteine	0,12	VCAM-1	21,27	Homocysteine	VCAM-1	MESH:D006710	7412	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Homocysteine induces VCAM-1 gene expression through NF-kappaB and NAD -LRB- P -RRB- H oxidase activation : protective role of Mediterranean diet polyphenolic antioxidants .
20018221	0	Homocysteine	0,12	X-box-binding_protein_1	21,44	Homocysteine	X-box-binding protein 1	MESH:D006710	22433(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Homocysteine induces X-box-binding_protein_1 splicing in the mice brain .
14567469	0	Homocysteine	0,12	butyrylcholinesterase	22,43	Homocysteine	butyrylcholinesterase	MESH:D006710	65036(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Homocysteine inhibits butyrylcholinesterase activity in rat serum .
15734734	0	Homocysteine	0,12	cellular_glutathione_peroxidase	28,59	Homocysteine	cellular glutathione peroxidase	MESH:D006710	2876	Chemical	Gene	down-regulates|amod|START_ENTITY END_ENTITY|nsubj|down-regulates	Homocysteine down-regulates cellular_glutathione_peroxidase -LRB- GPx1 -RRB- by decreasing translation .
18237028	0	Homocysteine	0,12	cellular_glutathione_peroxidase	24,55	Homocysteine	cellular glutathione peroxidase	MESH:D006710	2876	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Homocysteine effects on cellular_glutathione_peroxidase -LRB- GPx-1 -RRB- activity under in vitro conditions .
17944991	0	Homocysteine	0,12	connective_tissue_growth_factor	21,52	Homocysteine	connective tissue growth factor	MESH:D006710	64032(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Homocysteine induces connective_tissue_growth_factor expression in vascular smooth muscle cells .
17698632	0	Homocysteine	0,12	cyclin_A	77,85	Homocysteine	cyclin A	MESH:D006710	890	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|growth growth|nmod|hypomethylation hypomethylation|nmod|gene gene|compound|END_ENTITY	Homocysteine inhibits endothelial cell growth via DNA hypomethylation of the cyclin_A gene .
10406944	0	Homocysteine	0,12	endothelin-1	23,35	Homocysteine	endothelin-1	MESH:D006710	1906	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|production production|amod|END_ENTITY	Homocysteine decreases endothelin-1 production by cultured human endothelial cells .
12208352	0	Homocysteine	0,12	endothelin-1	23,35	Homocysteine	endothelin-1	MESH:D006710	1906	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|amod|END_ENTITY	Homocysteine decreases endothelin-1 expression by interfering with the AP-1 signaling pathway .
15504311	0	Homocysteine	1,13	growth_hormone	24,38	Homocysteine	growth hormone	MESH:D006710	2688	Chemical	Gene	levels|compound|START_ENTITY levels|nmod|END_ENTITY	-LSB- Homocysteine levels in growth_hormone deficient children and adolescents before and after one year of recombinant human growth_hormone -LRB- GH -RRB- replacement therapy -RSB- .
23567851	0	Homocysteine	0,12	heme_oxygenase-1	21,37	Homocysteine	heme oxygenase-1	MESH:D006710	3162	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Homocysteine induces heme_oxygenase-1 expression via transcription factor Nrf2 activation in HepG2 cell .
25520741	0	Homocysteine	0,12	heme_oxygenase-1	46,62	Homocysteine	heme oxygenase-1	MESH:D006710	15368(Tax:10090)	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|nmod|END_ENTITY	Homocysteine downregulates gene expression of heme_oxygenase-1 in hepatocytes .
12619887	0	Homocysteine	0,12	inducible_nitric_oxide_synthase	24,55	Homocysteine	inducible nitric oxide synthase	MESH:D006710	4843	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Homocysteine stimulates inducible_nitric_oxide_synthase expression in macrophages : antagonizing effect of ginkgolides and bilobalide .
11806465	0	Homocysteine	0,12	insulin	61,68	Homocysteine	insulin	MESH:D006710	3630	Chemical	Gene	levels|amod|START_ENTITY associated|nsubjpass|levels associated|nmod|resistance resistance|compound|END_ENTITY	Homocysteine plasma levels are independently associated with insulin resistance in normal weight , overweight and obese pre-menopausal women .
19369240	0	Homocysteine	0,12	lysyl_oxidase	136,149	Homocysteine	lysyl oxidase	MESH:D006710	4015	Chemical	Gene	levels|amod|START_ENTITY levels|dep|role role|nmod|END_ENTITY	Homocysteine levels in the vitreous of proliferative_diabetic_retinopathy and rhegmatogenous_retinal_detachment : its modulating role on lysyl_oxidase .
21148317	0	Homocysteine	0,12	lysyl_oxidase	68,81	Homocysteine	lysyl oxidase	MESH:D006710	16948(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|nmod|END_ENTITY	Homocysteine suppresses the expression of the collagen cross-linker lysyl_oxidase involving IL-6 , Fli1 , and epigenetic DNA methylation .
15842806	0	Homocysteine	1,13	macrophage_inflammatory_protein-1alpha	22,60	Homocysteine	macrophage inflammatory protein-1alpha	MESH:D006710	6348	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	-LSB- Homocysteine induces macrophage_inflammatory_protein-1alpha expression by activating NF-kappaB in THP-1 monocytes -RSB- .
16411407	0	Homocysteine	0,12	matrix_metalloproteinase-2	31,57	Homocysteine	matrix metalloproteinase-2	MESH:D006710	4313	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Homocysteine rapidly increases matrix_metalloproteinase-2 expression and activity in cultured human vascular smooth muscle cells .
12574198	0	Homocysteine	0,12	methylenetetrahydrofolate_reductase	46,81	Homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	levels|amod|START_ENTITY levels|nmod|END_ENTITY	Homocysteine levels and C677T polymorphism of methylenetetrahydrofolate_reductase in women with polycystic_ovary_syndrome .
14604831	0	Homocysteine	0,12	methylenetetrahydrofolate_reductase	41,76	Homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	status|amod|START_ENTITY status|nmod|END_ENTITY	Homocysteine status and polymorphisms of methylenetetrahydrofolate_reductase are not associated with restenosis after stenting in coronary arteries .
15210385	0	Homocysteine	129,141	methylenetetrahydrofolate_reductase	30,65	Homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	Study|compound|START_ENTITY Associations|dep|Study Associations|nmod|polymorphisms polymorphisms|compound|END_ENTITY	Associations between maternal methylenetetrahydrofolate_reductase polymorphisms and adverse outcomes of pregnancy : the Hordaland Homocysteine Study .
17298693	0	Homocysteine	0,12	methylenetetrahydrofolate_reductase	72,107	Homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	levels|amod|START_ENTITY associated|nsubjpass|levels associated|nmod|genotype genotype|amod|END_ENTITY	Homocysteine levels in children and adolescents are associated with the methylenetetrahydrofolate_reductase 677C > T genotype , but not with physical activity , fitness or fatness : the European Youth Heart Study .
19729099	0	Homocysteine	0,12	methylenetetrahydrofolate_reductase	14,49	Homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	START_ENTITY|appos|polymorphism polymorphism|amod|END_ENTITY	Homocysteine , methylenetetrahydrofolate_reductase C677T polymorphism , and risk of retinal_vein_occlusion : a meta-analysis .
25428529	0	Homocysteine	0,12	methylenetetrahydrofolate_reductase	14,49	Homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	C677T|advmod|START_ENTITY C677T|nsubj|END_ENTITY	Homocysteine , methylenetetrahydrofolate_reductase C677T polymorphism , and risk of retinal_vein_occlusion : an updated meta-analysis .
9733454	0	Homocysteine	0,12	methylenetetrahydrofolate_reductase	14,49	Homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	START_ENTITY|appos|polymorphism polymorphism|amod|END_ENTITY	Homocysteine , methylenetetrahydrofolate_reductase polymorphism , antiphospholipid antibodies , and thromboembolic events in systemic_lupus_erythematosus : a retrospective cohort study .
11216856	0	Homocysteine	0,12	monocyte_chemoattractant_protein-1	42,76	Homocysteine	monocyte chemoattractant protein-1	MESH:D006710	6347	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|nmod|chemotaxis chemotaxis|amod|END_ENTITY	Homocysteine stimulates the expression of monocyte_chemoattractant_protein-1 in endothelial cells leading to enhanced monocyte chemotaxis .
11356643	0	Homocysteine	0,12	monocyte_chemoattractant_protein-1	21,55	Homocysteine	monocyte chemoattractant protein-1	MESH:D006710	6347	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Homocysteine induces monocyte_chemoattractant_protein-1 expression by activating NF-kappaB in THP-1 macrophages .
11390343	0	Homocysteine	0,12	monocyte_chemoattractant_protein-1	49,83	Homocysteine	monocyte chemoattractant protein-1	MESH:D006710	6347	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|acl|END_ENTITY	Homocysteine induces expression and secretion of monocyte_chemoattractant_protein-1 and interleukin-8 in human aortic endothelial cells : implications for vascular_disease .
12881478	0	Homocysteine	0,12	monocyte_chemoattractant_protein-1	50,84	Homocysteine	monocyte chemoattractant protein-1	MESH:D006710	6347	Chemical	Gene	mediated|nsubj|START_ENTITY mediated|dobj|expression expression|acl|END_ENTITY	Homocysteine mediated expression and secretion of monocyte_chemoattractant_protein-1 and interleukin-8 in human monocytes .
15525462	0	Homocysteine	0,12	monocyte_chemoattractant_protein-1	35,69	Homocysteine	monocyte chemoattractant protein-1	MESH:D006710	6347	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|acl|END_ENTITY	Homocysteine induces production of monocyte_chemoattractant_protein-1 and interleukin-8 in cultured human whole blood .
17977907	0	Homocysteine	0,12	monocyte_chemoattractant_protein-1	24,58	Homocysteine	monocyte chemoattractant protein-1	MESH:D006710	24770(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Homocysteine stimulates monocyte_chemoattractant_protein-1 expression in the kidney via nuclear factor-kappaB activation .
18024959	0	Homocysteine	0,12	monocyte_chemoattractant_protein-1	21,55	Homocysteine	monocyte chemoattractant protein-1	MESH:D006710	24770(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Homocysteine induces monocyte_chemoattractant_protein-1 expression in hepatocytes mediated via activator_protein-1 activation .
18418435	0	Homocysteine	0,12	monocyte_chemoattractant_protein-1	24,58	Homocysteine	monocyte chemoattractant protein-1	MESH:D006710	6347	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Homocysteine stimulates monocyte_chemoattractant_protein-1 expression in mesangial cells via NF-kappaB activation .
11415454	0	Homocysteine	0,12	monocyte_chemoattractant_protein-1_receptor	42,85	Homocysteine	monocyte chemoattractant protein-1 receptor	MESH:D006710	729230	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|nmod|END_ENTITY	Homocysteine stimulates the expression of monocyte_chemoattractant_protein-1_receptor -LRB- CCR2 -RRB- in human monocytes : possible involvement of oxygen free radicals .
11104691	0	Homocysteine	0,12	nuclear_factor_kappaB	24,45	Homocysteine	nuclear factor kappaB	MESH:D006710	4790	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Homocysteine stimulates nuclear_factor_kappaB activity and monocyte_chemoattractant_protein-1 expression in vascular smooth-muscle cells : a possible role for protein_kinase_C .
15878736	0	Homocysteine	0,12	osteocalcin	42,53	Homocysteine	osteocalcin	MESH:D006710	12097(Tax:10090)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|nmod|END_ENTITY	Homocysteine attenuates the expression of osteocalcin but enhances osteopontin in MC3T3-E1 preosteoblastic cells .
22354938	0	Homocysteine	0,12	soluble_epoxide_hydrolase	25,50	Homocysteine	soluble epoxide hydrolase	MESH:D006710	2053	Chemical	Gene	upregulates|amod|START_ENTITY END_ENTITY|nsubj|upregulates	Homocysteine upregulates soluble_epoxide_hydrolase in vascular endothelium in vitro and in vivo .
11950695	0	Homocysteine	0,12	vascular_cell_adhesion_molecule-1	25,58	Homocysteine	vascular cell adhesion molecule-1	MESH:D006710	7412	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Homocysteine upregulates vascular_cell_adhesion_molecule-1 expression in cultured human aortic endothelial cells and enhances monocyte adhesion .
12957716	0	Homocysteine	0,12	vascular_endothelial_growth_factor	21,55	Homocysteine	vascular endothelial growth factor	MESH:D006710	7422	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Homocysteine induces vascular_endothelial_growth_factor expression in differentiated THP-1 macrophages .
14747470	0	Homocysteine	0,12	vascular_endothelial_growth_factor	41,75	Homocysteine	vascular endothelial growth factor	MESH:D006710	7422	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Homocysteine increases the expression of vascular_endothelial_growth_factor by a mechanism involving endoplasmic reticulum stress and transcription factor ATF4 .
25442261	9	Honokiol	1232,1240	EGFR	1283,1287	Honokiol	MEK2	MESH:C005499	5605	Chemical	Gene	bound|nsubj|START_ENTITY bound|nmod|END_ENTITY	Honokiol bound with comparable binding energies to EGFR -LRB- -7.30 0.01 kcal/mol -RRB- as the control drugs erlotinib -LRB- -7.50 0.30 kcal/mol -RRB- and gefitinib -LRB- -8.30 0.10 kcal/mol -RRB- .
16181613	0	Honokiol	0,8	NF-kappaB	39,48	Honokiol	NF-kappaB	MESH:C005499	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|compound|END_ENTITY	Honokiol inhibits TNF-alpha-stimulated NF-kappaB activation and NF-kappaB-regulated gene expression through suppression of IKK activation .
20388852	0	Honokiol	0,8	epidermal_growth_factor_receptor	18,50	Honokiol	epidermal growth factor receptor	MESH:C005499	1956	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Honokiol inhibits epidermal_growth_factor_receptor signaling and enhances the antitumor effects of epidermal_growth_factor_receptor inhibitors .
26020804	0	Honokiol	0,8	epidermal_growth_factor_receptor	83,115	Honokiol	epidermal growth factor receptor	MESH:C005499	1956	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	Honokiol inhibits the growth of head_and_neck_squamous_cell_carcinoma by targeting epidermal_growth_factor_receptor .
26020804	0	Honokiol	0,8	epidermal_growth_factor_receptor	83,115	Honokiol	epidermal growth factor receptor	MESH:C005499	1956	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	Honokiol inhibits the growth of head_and_neck_squamous_cell_carcinoma by targeting epidermal_growth_factor_receptor .
10720088	0	Hormone	0,7	interleukin-6	60,73	Hormone	interleukin-6	MESH:D006728	3569	Chemical	Gene	therapy|amod|START_ENTITY therapy|nmod|END_ENTITY	Hormone replacement therapy and interrelation between serum interleukin-6 and body mass index in postmenopausal women : a population-based study .
12106281	0	Hormones	15,23	Nerve_Growth_Factor	44,63	Hormones	Nerve Growth Factor	MESH:D006728	310738(Tax:10116)	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Glucocorticoid Hormones Negatively Regulate Nerve_Growth_Factor Expression In Vivo and in Cultured Rat Fibroblasts .
12106348	0	Hormones	107,115	Nerve_Growth_Factor	27,46	Hormones	Nerve Growth Factor	MESH:D006728	310738(Tax:10116)	Chemical	Gene	Synthesis|nmod|START_ENTITY Synthesis|nsubj|Regulation Regulation|nmod|END_ENTITY	Differential Regulation of Nerve_Growth_Factor -LRB- NGF -RRB- Synthesis in Neurons and Astrocytes by Glucocorticoid Hormones .
22525372	0	Houttuyninum	0,12	receptor_tyrosine_kinase	101,125	Houttuyninum	receptor tyrosine kinase	MESH:C572988	5979	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Houttuyninum , an active constituent of Chinese herbal medicine , inhibits phosphorylation of HER2/neu receptor_tyrosine_kinase and the tumor growth of HER2/neu-overexpressing cancer cells .
8865662	0	Hox	11,14	Sea	0,3	Hox	Sea	CHEBI:46904	3772221(Tax:7227)	Chemical	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	Sea urchin Hox genes : insights into the ancestral Hox cluster .
13296399	0	Huguenin	18,26	Ren	12,15	Huguenin	Ren	null	5972	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Professeur Ren Huguenin -RSB- .
12670303	0	Humanin	57,64	TRIM11	27,33	Humanin	TRIM11	null	81559	Chemical	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	A tripartite motif protein TRIM11 binds and destabilizes Humanin , a neuroprotective peptide against Alzheimer 's _ disease-relevant insults .
14560399	0	Humic_acid	0,10	PPAR-gamma	90,100	Humic acid	PPAR-gamma	null	5468	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Humic_acid induces the expression of ox-LDL receptor in HL-60 cells through activation of PPAR-gamma .
1534419	0	Humic_acid	0,10	plasmin	25,32	Humic acid	plasmin	null	5340	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	Humic_acid : inhibitor of plasmin .
9576176	0	Humic_acid	0,10	thrombomodulin	61,75	Humic acid	thrombomodulin	null	7056	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|activity activity|nmod|END_ENTITY	Humic_acid reduces protein-C-activating cofactor activity of thrombomodulin of human umbilical vein endothelial cells .
17372274	0	Humulone	0,8	COX-2	40,45	Humulone	COX-2	MESH:C007966	19225(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Humulone inhibits phorbol_ester-induced COX-2 expression in mouse skin by blocking activation of NF-kappaB and AP-1 : IkappaB kinase and c-Jun-N-terminal_kinase as respective potential upstream targets .
24067473	0	Huperzine_A	0,11	CCL2	21,25	Huperzine A	CCL2	MESH:C050426	20296(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	Huperzine_A inhibits CCL2 production in experimental_autoimmune_encephalomyelitis mice and in cultured astrocyte .
17305579	0	Huperzine_A	30,41	acetylcholinesterase	45,65	Huperzine A	acetylcholinesterase	MESH:C050426	43	Chemical	Gene	derived|nmod|START_ENTITY derived|nmod|inhibitors inhibitors|amod|END_ENTITY	Bivalent ligands derived from Huperzine_A as acetylcholinesterase inhibitors .
23440190	0	Huperzine_A	49,60	acetylcholinesterase	64,84	Huperzine A	acetylcholinesterase	MESH:C050426	43	Chemical	Gene	process|nmod|START_ENTITY landscape|nmod|process landscape|acl|END_ENTITY	Free energy landscape for the binding process of Huperzine_A to acetylcholinesterase .
26472141	0	Huperzine_A	80,91	acetylcholinesterase	49,69	Huperzine A	acetylcholinesterase	MESH:C050426	83817(Tax:10116)	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|Assessment Assessment|nmod|effects effects|nmod|END_ENTITY	Assessment of the neuroprotective effects of the acetylcholinesterase inhibitor Huperzine_A in an experimental spinal_cord_trauma model .
16111675	0	Huperzine_A	0,11	nerve_growth_factor	84,103	Huperzine A	nerve growth factor	MESH:C050426	4803	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|damage damage|nmod|production production|compound|END_ENTITY	Huperzine_A protects SHSY5Y neuroblastoma cells against oxidative stress damage via nerve_growth_factor production .
21533413	0	Hyaluronate	0,11	CD44	104,108	Hyaluronate	CD44	CHEBI:16336	960	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|phosphorylation phosphorylation|nmod|proteins proteins|nmod|kinase kinase|nmod|END_ENTITY	Hyaluronate activates tyrosine phosphorylation of cellular proteins including focal adhesion kinase via CD44 in human glioma cells .
7515923	0	Hyaluronate	0,11	CD44	78,82	Hyaluronate	CD44	CHEBI:16336	960	Chemical	Gene	costimulatory|nsubj|START_ENTITY costimulatory|xcomp|END_ENTITY	Hyaluronate is costimulatory for human T cell effector functions and binds to CD44 on activated T cells .
25210633	0	Hydralazine	0,11	myeloperoxidase	20,35	Hydralazine	myeloperoxidase	MESH:D006830	4353	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Hydralazine induces myeloperoxidase and proteinase_3 anti-neutrophil cytoplasmic antibody vasculitis and leads to pulmonary_renal_syndrome .
6993250	0	Hydralazine	0,11	renin	100,105	Hydralazine	renin	MESH:D006830	5972	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Hydralazine and oxprenolol in the treatment of hypertension and the effect of these drugs on plasma renin activity .
25704883	0	Hydrazinobenzoylcurcumin	0,24	androgen_receptor	34,51	Hydrazinobenzoylcurcumin	androgen receptor	null	11835(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	Hydrazinobenzoylcurcumin inhibits androgen_receptor activity and growth of castration-resistant_prostate_cancer in mice .
3093271	0	Hydrazone	0,9	diamine_oxidase	98,113	Hydrazone	diamine oxidase	CHEBI:38532	26	Chemical	Gene	formation|amod|START_ENTITY END_ENTITY|nsubj|formation	Hydrazone formation of 2,4-dinitrophenylhydrazine with pyrroloquinoline_quinone in porcine kidney diamine_oxidase .
3103131	0	Hydrocarbon	0,11	cytochrome_P-450	69,85	Hydrocarbon	cytochrome P-450	CHEBI:24632	100328948(Tax:9986)	Chemical	Gene	formation|compound|START_ENTITY formation|nmod|hydroperoxides hydroperoxides|nmod|END_ENTITY	Hydrocarbon formation in the reductive cleavage of hydroperoxides by cytochrome_P-450 .
12853844	0	Hydrochloric_acid	0,17	macrophage_migration_inhibitory_factor	37,75	Hydrochloric acid	macrophage migration inhibitory factor	MESH:D006851	103694877	Chemical	Gene	induced|nsubj|START_ENTITY induced|nmod|END_ENTITY	Hydrochloric_acid induced changes in macrophage_migration_inhibitory_factor in the bladder , peripheral and central nervous system of the rat .
22258466	0	Hydrochlorothiazide	66,85	Renin	44,49	Hydrochlorothiazide	Renin	MESH:D006852	5972	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|compound|END_ENTITY	Central Pressure and Biomarker Responses to Renin Inhibition with Hydrochlorothiazide and Ramipril in Obese Hypertensives : The ATTAIN Study .
21332024	0	Hydrochlorothiazide	0,19	serum_amyloid_A	121,136	Hydrochlorothiazide	serum amyloid A	MESH:D006852	6287	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Hydrochlorothiazide compared to candesartan treatment increases adipose tissue gene expression and circulating levels of serum_amyloid_A in hypertensive patients .
17805209	0	Hydrocortisone	0,14	EGF-R	52,57	Hydrocortisone	EGF-R	MESH:D006854	1956	Chemical	Gene	modulate|nsubj|START_ENTITY modulate|dobj|END_ENTITY	Hydrocortisone and indomethacin negatively modulate EGF-R signaling in human fetal intestine .
24518547	0	Hydrocortisone	0,14	Toll-like_receptor_4	23,43	Hydrocortisone	Toll-like receptor 4	MESH:D006854	7099	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|compound|END_ENTITY	Hydrocortisone reduces Toll-like_receptor_4 expression on peripheral CD14 + monocytes in patients undergoing percutaneous coronary intervention .
7686489	0	Hydrocortisone	0,14	alpha_2-macroglobulin	40,61	Hydrocortisone	alpha 2-macroglobulin	MESH:D006854	24153(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|synthesis synthesis|nmod|cells cells|amod|END_ENTITY	Hydrocortisone induces the synthesis of alpha_2-macroglobulin by rat mammary myoepithelial cells .
1980345	0	Hydrocortisone	0,14	arylsulfatase_A	25,40	Hydrocortisone	arylsulfatase A	MESH:D006854	11883(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Hydrocortisone regulates arylsulfatase_A -LRB- cerebroside-3-sulfate-3-sulfohydrolase -RRB- by decreasing the quantity of the enzyme in cultures of cells dissociated from embryonic mouse cerebra .
9845380	0	Hydrocortisone	0,14	granulocyte-macrophage_colony-stimulating_factor	24,72	Hydrocortisone	granulocyte-macrophage colony-stimulating factor	MESH:D006854	1437	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Hydrocortisone inhibits granulocyte-macrophage_colony-stimulating_factor production from normal human peripheral blood mononuclear cells and CD3 + T cells .
1493933	0	Hydrocortisone	0,14	interleukin-4	35,48	Hydrocortisone	interleukin-4	MESH:D006854	3565	Chemical	Gene	START_ENTITY|dobj|inhibition inhibition|nmod|END_ENTITY	Hydrocortisone inhibition of human interleukin-4 .
3386234	0	Hydrogen	0,8	C-3	61,64	Hydrogen	C-3	MESH:D006859	24232(Tax:10116)	Chemical	Gene	exchange|nsubj|START_ENTITY exchange|nmod|END_ENTITY	Hydrogen exchange during oxidoreduction and epimerization at C-3 of C19 steroid_sulphates in the rat .
21109867	0	Hydrogen	0,8	Mg2	62,65	Hydrogen	Mg2	MESH:D006859	4589	Chemical	Gene	properties|compound|START_ENTITY properties|nmod|END_ENTITY	Hydrogen storage properties and neutron scattering studies of Mg2 -LRB- dobdc -RRB- -- a metal-organic framework with open Mg2 + adsorption sites .
23475767	0	Hydrogen	0,8	Nrf2	51,55	Hydrogen	Nrf2	MESH:D006859	18024(Tax:10090)	Chemical	Gene	gas|compound|START_ENTITY reduces|nsubj|gas reduces|dobj|lung_injury lung_injury|nmod|pathway pathway|amod|END_ENTITY	Hydrogen gas reduces hyperoxic lung_injury via the Nrf2 pathway in vivo .
8294406	0	Hydrogen	0,8	TRH_receptor	107,119	Hydrogen	TRH receptor	MESH:D006859	7201	Chemical	Gene	interaction|compound|START_ENTITY interaction|nmod|END_ENTITY	Hydrogen bonding interaction of thyrotropin-releasing_hormone -LRB- TRH -RRB- with transmembrane_tyrosine 106 of the TRH_receptor .
19810732	0	Hydrogen	0,8	TiH2	49,53	Hydrogen	TiH2	MESH:D006859	10856	Chemical	Gene	properties|amod|START_ENTITY properties|nmod|END_ENTITY	Hydrogen storage properties of nanosized MgH2-0 .1 TiH2 prepared by ultrahigh-energy-high-pressure milling .
12604217	0	Hydrogen	0,8	aldose_reductase	38,54	Hydrogen	aldose reductase	MESH:D006859	231	Chemical	Gene	interactions|amod|START_ENTITY interactions|nmod|END_ENTITY	Hydrogen bonding interactions between aldose_reductase complexed with NADP -LRB- H -RRB- and inhibitor tolrestat studied by molecular dynamics simulations and binding assay .
5893923	2	Hydrogen	48,56	insulin	93,100	Hydrogen	insulin	MESH:D006859	3630	Chemical	Gene	bonding|compound|START_ENTITY bonding|nmod|molecule molecule|compound|END_ENTITY	Hydrogen bonding of tyrosine residues in the insulin molecule .
9445403	0	Hydrogen	0,8	rhodopsin	56,65	Hydrogen	rhodopsin	MESH:D006859	6010	Chemical	Gene	changes|amod|START_ENTITY changes|nmod|END_ENTITY	Hydrogen bonding changes of internal water molecules in rhodopsin during metarhodopsin I and metarhodopsin II formation .
8294406	0	Hydrogen	0,8	thyrotropin-releasing_hormone	32,61	Hydrogen	thyrotropin-releasing hormone	MESH:D006859	7200	Chemical	Gene	interaction|compound|START_ENTITY interaction|nmod|END_ENTITY	Hydrogen bonding interaction of thyrotropin-releasing_hormone -LRB- TRH -RRB- with transmembrane_tyrosine 106 of the TRH_receptor .
25220136	0	Hydrogen_Peroxide	0,17	CFTR	33,37	Hydrogen Peroxide	CFTR	MESH:D006861	1080	Chemical	Gene	Stimulation|compound|START_ENTITY Stimulation|nmod|END_ENTITY	Hydrogen_Peroxide Stimulation of CFTR Reveals an EPAC-Mediated , Soluble Adenylyl Cyclase Dependent cAMP Amplification Pathway Common to GPCR Signaling .
24684506	0	Hydrogen_Sulfide	0,16	EGFR	25,29	Hydrogen Sulfide	EGFR	MESH:D006862	24329(Tax:10116)	Chemical	Gene	Residues|compound|START_ENTITY Residues|compound|END_ENTITY	Hydrogen_Sulfide Targets EGFR Cys797/Cys798 Residues to Induce Na -LRB- + -RRB- / K -LRB- + -RRB- - ATPase Endocytosis and Inhibition in Renal Tubular Epithelial Cells and Increase Sodium Excretion in Chronic Salt-Loaded Rats .
26880412	0	Hydrogen_Sulfide	0,16	Erythropoietin	25,39	Hydrogen Sulfide	Erythropoietin	MESH:D006862	2056	Chemical	Gene	Synthesis|compound|START_ENTITY Synthesis|compound|END_ENTITY	Hydrogen_Sulfide Induced Erythropoietin Synthesis Is Regulated by HIF Proteins .
26154696	0	Hydrogen_Sulfide	0,16	IL-6	62,66	Hydrogen Sulfide	IL-6	MESH:D006862	16193(Tax:10090)	Chemical	Gene	Hepcidin|compound|START_ENTITY Hepcidin|acl|Reducing Reducing|dobj|Secretion Secretion|compound|END_ENTITY	Hydrogen_Sulfide Attenuates Inflammatory Hepcidin by Reducing IL-6 Secretion and Promoting SIRT1-Mediated STAT3 Deacetylation .
26237624	0	Hydrogen_Sulfide	38,54	PF6	66,69	Hydrogen Sulfide	PF6	MESH:D006862	200162	Chemical	Gene	START_ENTITY|nmod|-RSB- -RSB-|compound|END_ENTITY	Solvation Thermodynamic Properties of Hydrogen_Sulfide in -LSB- C4mim -RSB- -LSB- PF6 -RSB- , -LSB- C4mim -RSB- -LSB- BF4 -RSB- , and -LSB- C4mim -RSB- -LSB- Cl -RSB- Ionic Liquids , Determined by Molecular Simulations .
25758951	0	Hydrogen_Sulfide	0,16	TFAM	78,82	Hydrogen Sulfide	TFAM	MESH:D006862	21780(Tax:10090)	Chemical	Gene	Replication|compound|START_ENTITY Replication|nmod|END_ENTITY	Hydrogen_Sulfide Maintains Mitochondrial DNA Replication via Demethylation of TFAM .
25405338	0	Hydrogen_Sulfide	54,70	miR-34a	12,19	Hydrogen Sulfide	miR-34a	MESH:D006862	100314015(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	The Role of miR-34a in the Hepatoprotective Effect of Hydrogen_Sulfide on Ischemia/Reperfusion Injury in Young and Old Rats .
20159686	0	Hydrogen_dioxide	1,17	vascular_endothelial_growth_factor	46,80	Hydrogen dioxide	vascular endothelial growth factor	CHEBI:25935	7422	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	-LSB- Hydrogen_dioxide increases the expression of vascular_endothelial_growth_factor in human bronchiolar epithelium cell via a PI3K-dependent pathway -RSB- .
11728469	0	Hydrogen_peroxide	0,17	ABI1	36,40	Hydrogen peroxide	ABI1	MESH:D006861	828714(Tax:3702)	Chemical	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	Hydrogen_peroxide is a regulator of ABI1 , a protein phosphatase 2C from Arabidopsis .
18081811	0	Hydrogen_peroxide	0,17	AMP-activated_protein_kinase	55,83	Hydrogen peroxide	AMP-activated protein kinase	MESH:D006861	78975(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Hydrogen_peroxide induces expression and activation of AMP-activated_protein_kinase in a dental pulp cell line .
24332816	0	Hydrogen_peroxide	0,17	DUOX1	31,36	Hydrogen peroxide	DUOX1	MESH:D006861	53905	Chemical	Gene	START_ENTITY|acl|generated generated|nmod|END_ENTITY	Hydrogen_peroxide generated by DUOX1 regulates the expression levels of specific differentiation markers in normal human keratinocytes .
24462874	0	Hydrogen_peroxide	0,17	ERK5	32,36	Hydrogen peroxide	ERK5	MESH:D006861	5598	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Hydrogen_peroxide activation of ERK5 confers resistance to Jurkat cells against apoptosis induced by the extrinsic pathway .
15327748	0	Hydrogen_peroxide	0,17	GADD153	26,33	Hydrogen peroxide	GADD153	MESH:D006861	1649	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Hydrogen_peroxide induces GADD153 in Jurkat cells through the protein kinase C-dependent pathway .
10946242	0	Hydrogen_peroxide	0,17	HPRT	43,47	Hydrogen peroxide	HPRT	MESH:D006861	3251	Chemical	Gene	mutations|amod|START_ENTITY mutations|nmod|END_ENTITY	Hydrogen_peroxide induced mutations at the HPRT locus in primary human T-lymphocytes .
11893856	0	Hydrogen_peroxide	0,17	IL-5	27,31	Hydrogen peroxide	IL-5	MESH:D006861	3567	Chemical	Gene	reverses|nsubj|START_ENTITY reverses|dobj|END_ENTITY	Hydrogen_peroxide reverses IL-5 afforded eosinophil survival and promotes constitutive human eosinophil apoptosis .
23510996	0	Hydrogen_peroxide	0,17	LPA_receptor-3	58,72	Hydrogen peroxide	LPA receptor-3	MESH:D006861	66025(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|END_ENTITY	Hydrogen_peroxide stimulates cell motile activity through LPA_receptor-3 in liver epithelial WB-F344 cells .
18474597	0	Hydrogen_peroxide	0,17	NF-kappaB	51,60	Hydrogen peroxide	NF-kappaB	MESH:D006861	4790	Chemical	Gene	prolongs|nsubj|START_ENTITY prolongs|dobj|localization localization|nmod|END_ENTITY	Hydrogen_peroxide prolongs nuclear localization of NF-kappaB in activated cells by suppressing negative regulatory mechanisms .
12711606	0	Hydrogen_peroxide	0,17	NF-kappa_B	28,38	Hydrogen peroxide	NF-kappa B	MESH:D006861	4790	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|kinase kinase|amod|END_ENTITY	Hydrogen_peroxide activates NF-kappa_B through tyrosine phosphorylation of I_kappa_B_alpha and serine phosphorylation of p65 : evidence for the involvement of I_kappa_B_alpha kinase and Syk protein-tyrosine kinase .
11491660	0	Hydrogen_peroxide	0,17	NFkappaB	28,36	Hydrogen peroxide	NFkappaB	MESH:D006861	4790	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Hydrogen_peroxide activates NFkappaB and the interleukin-6 promoter through NFkappaB-inducing_kinase .
11491660	0	Hydrogen_peroxide	0,17	NFkappaB-inducing_kinase	76,100	Hydrogen peroxide	NFkappaB-inducing kinase	MESH:D006861	9020	Chemical	Gene	activates|nsubj|START_ENTITY activates|nmod|END_ENTITY	Hydrogen_peroxide activates NFkappaB and the interleukin-6 promoter through NFkappaB-inducing_kinase .
26603095	0	Hydrogen_peroxide	0,17	RPSA	67,71	Hydrogen peroxide	RPSA	MESH:D006861	3921	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Hydrogen_peroxide regulates cell adhesion through the redox sensor RPSA .
15475011	0	Hydrogen_peroxide	0,17	S6K1	46,50	Hydrogen peroxide	S6K1	MESH:D006861	83840(Tax:10116)	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|nmod|END_ENTITY	Hydrogen_peroxide mediates Rac1 activation of S6K1 .
10551813	0	Hydrogen_peroxide	0,17	S6k	32,35	Hydrogen peroxide	S6k	MESH:D006861	72508(Tax:10090)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Hydrogen_peroxide activates p70 -LRB- S6k -RRB- signaling pathway .
16941746	0	Hydrogen_peroxide	0,17	TNF-related_apoptosis-inducing_ligand	30,67	Hydrogen peroxide	TNF-related apoptosis-inducing ligand	MESH:D006861	8743	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Hydrogen_peroxide upregulates TNF-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- expression in human astroglial cells , and augments apoptosis of T cells .
16199533	0	Hydrogen_peroxide	0,17	activator_protein-1	110,129	Hydrogen peroxide	activator protein-1	MESH:D006861	3725	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|activation activation|nmod|END_ENTITY	Hydrogen_peroxide stimulates proliferation and migration of human prostate_cancer cells through activation of activator_protein-1 and up-regulation of the heparin_affin_regulatory_peptide gene .
12063315	0	Hydrogen_peroxide	0,17	bradykinin	80,90	Hydrogen peroxide	bradykinin	MESH:D006861	3827	Chemical	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	Hydrogen_peroxide acts as an EDHF in the piglet pial vasculature in response to bradykinin .
10936514	0	Hydrogen_peroxide	0,17	c-Jun_N-terminal_kinase	102,125	Hydrogen peroxide	c-Jun N-terminal kinase	MESH:D006861	26419(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|response response|acl|lipopolysaccharide lipopolysaccharide|advcl|attenuating attenuating|advcl|signaling signaling|nmod|END_ENTITY	Hydrogen_peroxide inhibits the immune response to lipopolysaccharide by attenuating signaling through c-Jun_N-terminal_kinase and p38 associated with protein kinase C .
12939259	0	Hydrogen_peroxide	0,17	c-Jun_N-terminal_kinase	102,125	Hydrogen peroxide	c-Jun N-terminal kinase	MESH:D006861	26419(Tax:10090)	Chemical	Gene	leads|nsubj|START_ENTITY leads|nmod|activation activation|nmod|END_ENTITY	Hydrogen_peroxide signaling through tumor_necrosis_factor_receptor_1 leads to selective activation of c-Jun_N-terminal_kinase .
11033421	0	Hydrogen_peroxide	0,17	caspase-3	65,74	Hydrogen peroxide	caspase-3	MESH:D006861	836	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	Hydrogen_peroxide inhibits activation , not activity , of cellular caspase-3 in vivo .
11891305	0	Hydrogen_peroxide	0,17	catalase	51,59	Hydrogen peroxide	catalase	MESH:D006861	847	Chemical	Gene	homeostasis|amod|START_ENTITY homeostasis|dep|activation activation|nmod|END_ENTITY	Hydrogen_peroxide homeostasis : activation of plant catalase by calcium/calmodulin .
1646749	0	Hydrogen_peroxide	0,17	catalase	55,63	Hydrogen peroxide	catalase	MESH:D006861	24248(Tax:10116)	Chemical	Gene	START_ENTITY|dep|effect effect|nmod|inhibition inhibition|amod|END_ENTITY	Hydrogen_peroxide and ischemic_renal_injury : effect of catalase inhibition .
23643711	0	Hydrogen_peroxide	0,17	catalase	111,119	Hydrogen peroxide	catalase	MESH:D006861	847	Chemical	Gene	production|amod|START_ENTITY regulates|nsubj|production regulates|dobj|function function|dep|effect effect|nmod|overexpression overexpression|amod|END_ENTITY	Hydrogen_peroxide production regulates the mitochondrial function in insulin resistant muscle cells : effect of catalase overexpression .
2881544	0	Hydrogen_peroxide	0,17	catalase	141,149	Hydrogen peroxide	catalase	MESH:D006861	531682(Tax:9913)	Chemical	Gene	activation|amod|START_ENTITY cyclase|nsubj|activation cyclase|nmod|mechanism mechanism|acl|associated associated|nmod|END_ENTITY	Hydrogen_peroxide elicits activation of bovine pulmonary arterial soluble guanylate cyclase by a mechanism associated with its metabolism by catalase .
8667243	0	Hydrogen_peroxide	0,17	catalase	172,180	Hydrogen peroxide	catalase	MESH:D006861	847	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|parataxis|END_ENTITY	Hydrogen_peroxide mediates the killing of U937 tumor cells elicited by pharmacologically attainable concentrations of ascorbic_acid : cell death prevention by extracellular catalase or catalase from cocultured erythrocytes or fibroblasts .
9863948	0	Hydrogen_peroxide	0,17	catalase	89,97	Hydrogen peroxide	catalase	MESH:D006861	847	Chemical	Gene	determination|amod|START_ENTITY determination|acl|using using|dobj|biosensor biosensor|compound|END_ENTITY	Hydrogen_peroxide determination in pharmaceutical formulations and cosmetics using a new catalase biosensor .
11409888	0	Hydrogen_peroxide	0,17	connective_tissue_growth_factor	40,71	Hydrogen peroxide	connective tissue growth factor	MESH:D006861	1490	Chemical	Gene	inducer|nsubj|START_ENTITY inducer|nmod|END_ENTITY	Hydrogen_peroxide is a novel inducer of connective_tissue_growth_factor .
18272918	0	Hydrogen_peroxide	0,17	copper_amine_oxidase	31,51	Hydrogen peroxide	copper amine oxidase	MESH:D006861	8639	Chemical	Gene	START_ENTITY|acl|generated generated|nmod|END_ENTITY	Hydrogen_peroxide generated by copper_amine_oxidase is involved in abscisic_acid-induced stomatal closure in Vicia faba .
14989826	0	Hydrogen_peroxide	1,18	cyclooxygenase-2	57,73	Hydrogen peroxide	cyclooxygenase-2	MESH:D006861	5743	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	-LSB- Hydrogen_peroxide upregulates interleukin-1beta-induced cyclooxygenase-2 expression in human pulmonary epithelial cells -RSB- .
20665602	0	Hydrogen_peroxide	0,17	cyclooxygenase-2	74,90	Hydrogen peroxide	cyclooxygenase-2	MESH:D006861	5743	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|mechanism mechanism|amod|dependent dependent|amod|END_ENTITY	Hydrogen_peroxide regulates glucose-regulated_protein_78 expression via a cyclooxygenase-2 dependent mechanism .
18556800	0	Hydrogen_peroxide	0,17	endothelial_nitric_oxide_synthase	28,61	Hydrogen peroxide	endothelial nitric oxide synthase	MESH:D006861	4846	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|activity activity|amod|END_ENTITY	Hydrogen_peroxide decreases endothelial_nitric_oxide_synthase promoter activity through the inhibition of AP-1 activity .
19105596	0	Hydrogen_peroxide	0,17	endothelial_nitric_oxide_synthase	28,61	Hydrogen peroxide	endothelial nitric oxide synthase	MESH:D006861	4846	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|activity activity|amod|END_ENTITY	Hydrogen_peroxide decreases endothelial_nitric_oxide_synthase promoter activity through the inhibition of Sp1 activity .
10656288	0	Hydrogen_peroxide	0,17	epidermal_growth_factor_receptor	27,59	Hydrogen peroxide	epidermal growth factor receptor	MESH:D006861	1956	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|internalization internalization|compound|END_ENTITY	Hydrogen_peroxide inhibits epidermal_growth_factor_receptor internalization in human fibroblasts .
11346883	0	Hydrogen_peroxide	0,17	epidermal_growth_factor_receptor	109,141	Hydrogen peroxide	epidermal growth factor receptor	MESH:D006861	24329(Tax:10116)	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|activation activation|nmod|END_ENTITY	Hydrogen_peroxide promotes transformation of rat liver non-neoplastic epithelial cells through activation of epidermal_growth_factor_receptor .
7805884	0	Hydrogen_peroxide	0,17	epidermal_growth_factor_receptor	74,106	Hydrogen peroxide	epidermal growth factor receptor	MESH:D006861	1956	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Hydrogen_peroxide preferentially enhances the tyrosine phosphorylation of epidermal_growth_factor_receptor .
17442163	0	Hydrogen_peroxide	1,18	erythropoietin	59,73	Hydrogen peroxide	erythropoietin	MESH:D006861	2056	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	-LSB- Hydrogen_peroxide induces expression and transcription of erythropoietin in the human retinal pigment epithelium cells -RSB- .
8756058	0	Hydrogen_peroxide	0,17	erythropoietin	39,53	Hydrogen peroxide	erythropoietin	MESH:D006861	2056	Chemical	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Hydrogen_peroxide in the regulation of erythropoietin -LRB- Epo -RRB- gene expression in hepatocellular_carcinoma cells .
10409242	0	Hydrogen_peroxide	0,17	focal_adhesion_kinase	57,78	Hydrogen peroxide	focal adhesion kinase	MESH:D006861	506270(Tax:9913)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Hydrogen_peroxide stimulates tyrosine phosphorylation of focal_adhesion_kinase in vascular endothelial cells .
20665602	0	Hydrogen_peroxide	0,17	glucose-regulated_protein_78	28,56	Hydrogen peroxide	glucose-regulated protein 78	MESH:D006861	3309	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Hydrogen_peroxide regulates glucose-regulated_protein_78 expression via a cyclooxygenase-2 dependent mechanism .
22931605	0	Hydrogen_peroxide	1,18	high_mobility_group_box_1_release	27,60	Hydrogen peroxide	high mobility group box 1 release	MESH:D006861	3146	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	-LSB- Hydrogen_peroxide induces high_mobility_group_box_1_release in human bronchial epithelial cells -RSB- .
9227632	0	Hydrogen_peroxide	0,17	iNOS	54,58	Hydrogen peroxide	iNOS	MESH:D006861	24599(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Hydrogen_peroxide downregulates IL-1-driven mesangial iNOS activity : implications for glomerulonephritis .
2833239	0	Hydrogen_peroxide	0,17	insulin_receptor	61,77	Hydrogen peroxide	insulin receptor	MESH:D006861	24954(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Hydrogen_peroxide stimulates tyrosine phosphorylation of the insulin_receptor and its tyrosine kinase activity in intact cells .
19539716	0	Hydrogen_peroxide	0,17	mTOR	105,109	Hydrogen peroxide	mTOR	MESH:D006861	21977(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|death death|nmod|cells cells|nmod|suppression suppression|nmod|pathway pathway|compound|END_ENTITY	Hydrogen_peroxide induces autophagic cell death in C6 glioma cells via BNIP3-mediated suppression of the mTOR pathway .
20142804	0	Hydrogen_peroxide	0,17	mTOR	27,31	Hydrogen peroxide	mTOR	MESH:D006861	21977(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Hydrogen_peroxide inhibits mTOR signaling by activation of AMPKalpha leading to apoptosis of neuronal cells .
21067284	0	Hydrogen_peroxide	0,17	mTOR	88,92	Hydrogen peroxide	mTOR	MESH:D006861	21977(Tax:10090)	Chemical	Gene	induces|dep|START_ENTITY induces|dep|suppressing suppressing|dobj|pathway pathway|compound|END_ENTITY	Hydrogen_peroxide induces Beclin 1-independent autophagic cell death by suppressing the mTOR pathway via promoting the ubiquitination and degradation of Rheb in GSH-depleted RAW 264.7 cells .
12726922	0	Hydrogen_peroxide	0,17	nitric_oxide_synthase	119,140	Hydrogen peroxide	nitric oxide synthase	MESH:D006861	4843	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|induction induction|nmod|activity activity|compound|END_ENTITY	Hydrogen_peroxide stimulates tetrahydrobiopterin synthesis through the induction of GTP-cyclohydrolase_I and increases nitric_oxide_synthase activity in vascular endothelial cells .
19076167	0	Hydrogen_peroxide	0,17	osteopontin	27,38	Hydrogen peroxide	osteopontin	MESH:D006861	6696	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	Hydrogen_peroxide enhances osteopontin expression and matrix metalloproteinase activity in aortic vascular smooth muscle cells .
20069554	0	Hydrogen_peroxide	0,17	p16	26,29	Hydrogen peroxide	p16	MESH:D006861	1029	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Hydrogen_peroxide induces p16 -LRB- INK4a -RRB- through an AUF1-dependent manner .
10064887	0	Hydrogen_peroxide	0,17	p53	51,54	Hydrogen peroxide	p53	MESH:D006861	7157	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|translocation translocation|nmod|END_ENTITY	Hydrogen_peroxide induces nuclear translocation of p53 and apoptosis in cells of oligodendroglia origin .
17593873	0	Hydrogen_peroxide	0,17	pigment_epithelium-derived_factor	29,62	Hydrogen peroxide	pigment epithelium-derived factor	MESH:D006861	57104	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|gene gene|amod|END_ENTITY	Hydrogen_peroxide stimulates pigment_epithelium-derived_factor gene and protein expression in the human hepatocyte cell line OUMS-29 .
12939259	0	Hydrogen_peroxide	0,17	tumor_necrosis_factor_receptor_1	36,68	Hydrogen peroxide	tumor necrosis factor receptor 1	MESH:D006861	21937(Tax:10090)	Chemical	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Hydrogen_peroxide signaling through tumor_necrosis_factor_receptor_1 leads to selective activation of c-Jun_N-terminal_kinase .
21998720	0	Hydrogen_sulfide	0,16	ERK1/2	94,100	Hydrogen sulfide	ERK1/2	MESH:D006862	50689;116590	Chemical	Gene	protects|nsubj|START_ENTITY protects|advcl|inhibiting inhibiting|dobj|END_ENTITY	Hydrogen_sulfide protects against chemical hypoxia-induced injury by inhibiting ROS-activated ERK1/2 and p38MAPK signaling pathways in PC12 cells .
20211170	0	Hydrogen_sulfide	0,16	ICAM-1	25,31	Hydrogen sulfide	ICAM-1	MESH:D006862	15894(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Hydrogen_sulfide induces ICAM-1 expression and neutrophil adhesion to caerulein-treated pancreatic acinar cells through NF-kappaB and Src-family kinases pathway .
26760196	0	Hydrogen_sulfide	0,16	IL-6	109,113	Hydrogen sulfide	IL-6	MESH:D006862	24498(Tax:10116)	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|advcl|suppressing suppressing|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Hydrogen_sulfide prevents OGD/R-induced apoptosis by suppressing the phosphorylation of p38 and secretion of IL-6 in PC12 cells .
21297080	0	Hydrogen_sulfide	0,16	IL-8	55,59	Hydrogen sulfide	IL-8	MESH:D006862	3576	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|proliferation proliferation|nmod|END_ENTITY	Hydrogen_sulfide inhibits proliferation and release of IL-8 from human airway_smooth_muscle cells .
21555999	0	Hydrogen_sulfide	0,16	IL-8	26,30	Hydrogen sulfide	IL-8	MESH:D006862	3576	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Hydrogen_sulfide inhibits IL-8 expression in human keratinocytes via MAP kinase signaling .
23974514	0	Hydrogen_sulfide	0,16	MMP-8	46,51	Hydrogen sulfide	MMP-8	MESH:D006862	63849(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|nmod|END_ENTITY	Hydrogen_sulfide suppresses the expression of MMP-8 , MMP-13 , and TIMP-1 in left ventricles of rats with cardiac volume_overload .
17209138	0	Hydrogen_sulfide	0,16	NF-kappaB	167,176	Hydrogen sulfide	NF-kappaB	MESH:D006862	18033(Tax:10090)	Chemical	Gene	acts|nsubj|START_ENTITY acts|advcl|upregulating upregulating|dobj|production production|nmod|cytokines cytokines|nmod|END_ENTITY	Hydrogen_sulfide acts as an inflammatory mediator in cecal_ligation_and_puncture-induced sepsis in mice by upregulating the production of cytokines and chemokines via NF-kappaB .
20211170	0	Hydrogen_sulfide	0,16	NF-kappaB	120,129	Hydrogen sulfide	NF-kappaB	MESH:D006862	18033(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|pathway pathway|compound|END_ENTITY	Hydrogen_sulfide induces ICAM-1 expression and neutrophil adhesion to caerulein-treated pancreatic acinar cells through NF-kappaB and Src-family kinases pathway .
19608979	0	Hydrogen_sulfide	0,16	Nrf2	51,55	Hydrogen sulfide	Nrf2	MESH:D006862	18024(Tax:10090)	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Hydrogen_sulfide mediates cardioprotection through Nrf2 signaling .
23297114	0	Hydrogen_sulfide	0,16	TNF-a	107,112	Hydrogen sulfide	TNF-a	MESH:D006862	7124	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|activation activation|amod|END_ENTITY	Hydrogen_sulfide reduces cell adhesion and relevant inflammatory triggering by preventing ADAM17-dependent TNF-a activation .
24665821	0	Hydrogen_sulfide	0,16	glutamate-cysteine_ligase_catalytic_subunit	29,72	Hydrogen sulfide	glutamate-cysteine ligase catalytic subunit	MESH:D006862	2729	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	Hydrogen_sulfide upregulates glutamate-cysteine_ligase_catalytic_subunit , glutamate-cysteine_ligase_modifier_subunit , and glutathione and inhibits interleukin-1b secretion in monocytes exposed to high glucose levels .
16781459	0	Hydrogen_sulfide	0,16	heme_oxygenase-1	80,96	Hydrogen sulfide	heme oxygenase-1	MESH:D006862	3162	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|nmod|expression expression|amod|END_ENTITY	Hydrogen_sulfide inhibits nitric_oxide production and nuclear factor-kappaB via heme_oxygenase-1 expression in RAW264 .7 macrophages stimulated with lipopolysaccharide .
23852531	0	Hydrogen_sulfide	0,16	heme_oxygenase-1	25,41	Hydrogen sulfide	heme oxygenase-1	MESH:D006862	3162	Chemical	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Hydrogen_sulfide induces heme_oxygenase-1 in human kidney cells .
24648967	0	Hydrogen_sulfide	0,16	heme_oxygenase-1	29,45	Hydrogen sulfide	heme oxygenase-1	MESH:D006862	24451(Tax:10116)	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Hydrogen_sulfide upregulates heme_oxygenase-1 expression in rats with volume_overload-induced heart_failure .
19889840	0	Hydrogen_sulfide	0,16	hypoxia-inducible_factor-1	27,53	Hydrogen sulfide	hypoxia-inducible factor-1	MESH:D006862	180359(Tax:6239)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|activity activity|amod|END_ENTITY	Hydrogen_sulfide increases hypoxia-inducible_factor-1 activity independently of von_Hippel-Lindau_tumor suppressor-1 in C. _ elegans .
22831549	0	Hydrogen_sulfide	0,16	hypoxia-inducible_factor-1a	58,85	Hydrogen sulfide	hypoxia-inducible factor-1a	MESH:D006862	3091	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Hydrogen_sulfide inhibits the translational expression of hypoxia-inducible_factor-1a .
23676335	0	Hydrogen_sulfide	0,16	intercellular_adhesion_molecule-1	63,96	Hydrogen sulfide	intercellular adhesion molecule-1	MESH:D006862	3383	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|nmod|END_ENTITY	Hydrogen_sulfide suppresses high glucose-induced expression of intercellular_adhesion_molecule-1 in endothelial cells .
26760196	0	Hydrogen_sulfide	0,16	p38	88,91	Hydrogen sulfide	p38	MESH:D006862	81649(Tax:10116)	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|advcl|suppressing suppressing|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Hydrogen_sulfide prevents OGD/R-induced apoptosis by suppressing the phosphorylation of p38 and secretion of IL-6 in PC12 cells .
20360313	0	Hydrogen_sulfide	0,16	renin	33,38	Hydrogen sulfide	renin	MESH:D006862	24715(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	Hydrogen_sulfide inhibits plasma renin activity .
15129224	0	Hydroquinone	0,12	GM-CSF	27,33	Hydroquinone	GM-CSF	MESH:C031927	1437	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Hydroquinone modulates the GM-CSF signaling pathway in TF-1 cells .
18409047	0	Hydroquinone	0,12	IFN-gamma	60,69	Hydroquinone	IFN-gamma	MESH:C031927	3458	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|production production|amod|END_ENTITY	Hydroquinone , a major component in cigarette smoke , reduces IFN-gamma production in antigen-primed lymphocytes .
10890505	0	Hydroquinone	0,12	NFkappaB	48,56	Hydroquinone	NFkappaB	MESH:C031927	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	Hydroquinone inhibits PMA-induced activation of NFkappaB in primary human CD19 + B lymphocytes .
23290930	0	Hydroquinone	0,12	hemeoxygenase-1	23,38	Hydroquinone	hemeoxygenase-1	MESH:C031927	3162	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Hydroquinone regulates hemeoxygenase-1 expression via modulation of Src kinase activity through thiolation of cysteine residues .
12153512	0	Hydroquinone	0,12	interleukin-4	57,70	Hydroquinone	interleukin-4	MESH:C031927	16189(Tax:10090)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|compound|END_ENTITY	Hydroquinone , a reactive metabolite of benzene , enhances interleukin-4 production in CD4 + T cells and increases immunoglobulin E levels in antigen-primed mice .
23940045	0	Hydroquinone	0,12	ten_eleven_translocation_1	65,91	Hydroquinone	ten eleven translocation 1	MESH:C031927	80312	Chemical	Gene	increases|nsubj|START_ENTITY increases|nmod|END_ENTITY	Hydroquinone increases 5-hydroxymethylcytosine formation through ten_eleven_translocation_1 -LRB- TET1 -RRB- 5-methylcytosine dioxygenase .
2308149	0	Hydroxamic_acid	0,15	5-lipoxygenase	30,44	Hydroxamic acid	5-lipoxygenase	MESH:D006877	240	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Hydroxamic_acid inhibitors of 5-lipoxygenase : quantitative structure-activity relationships .
3820229	0	Hydroxamic_acid	0,15	5-lipoxygenase	30,44	Hydroxamic acid	5-lipoxygenase	MESH:D006877	240	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Hydroxamic_acid inhibitors of 5-lipoxygenase .
1793063	0	Hydroxamic_acids	0,16	5-lipoxygenase	54,68	Hydroxamic acids	5-lipoxygenase	MESH:D006877	240	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Hydroxamic_acids and hydroxyureas as novel , selective 5-lipoxygenase inhibitors for possible use in asthma .
17767493	0	Hydroxy-alpha-sanshool	0,22	TRPV1	33,38	Hydroxy-alpha-sanshool	TRPV1	null	193034(Tax:10090)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Hydroxy-alpha-sanshool activates TRPV1 and TRPA1 in sensory neurons .
21454438	1	Hydroxy-carboxylic_Acid	99,122	GPR81	134,139	Hydroxy-carboxylic Acid	GPR81	CHEBI:24669	27198	Chemical	Gene	Receptors|amod|START_ENTITY Receptors|dep|END_ENTITY	LXXXII : Nomenclature and Classification of Hydroxy-carboxylic_Acid Receptors -LRB- GPR81 , GPR109A , and GPR109B -RRB- .
3341750	0	Hydroxyamino_acid	0,17	smooth_muscle_myosin_light_chain_kinase	33,72	Hydroxyamino acid	smooth muscle myosin light chain kinase	CHEBI:24662	4638	Chemical	Gene	specificity|amod|START_ENTITY specificity|nmod|END_ENTITY	Hydroxyamino_acid specificity of smooth_muscle_myosin_light_chain_kinase .
24900524	0	Hydroxybenzoic_Acids	18,38	GPR81	70,75	Hydroxybenzoic Acids	GPR81	MESH:D062385	243270(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|Receptor Receptor|appos|END_ENTITY	Identification of Hydroxybenzoic_Acids as Selective Lactate Receptor -LRB- GPR81 -RRB- Agonists with Antilipolytic Effects .
23761079	0	Hydroxycamptothecin	0,19	PERK	93,97	Hydroxycamptothecin	PERK	null	9451	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|activating activating|dobj|END_ENTITY	Hydroxycamptothecin induces apoptosis of human tenon 's capsule fibroblasts by activating the PERK signaling pathway .
21943109	0	Hydroxychavicol	0,15	JNK	134,137	Hydroxychavicol	JNK	MESH:C051268	5599	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Hydroxychavicol , a Piper betle leaf component , induces apoptosis of CML cells through mitochondrial reactive oxygen species-dependent JNK and endothelial nitric_oxide synthase activation and overrides imatinib resistance .
19965621	0	Hydroxychloroquine	0,18	annexin_A5	32,42	Hydroxychloroquine	annexin A5	MESH:D006886	308	Chemical	Gene	protects|nsubj|START_ENTITY protects|dobj|shield shield|amod|END_ENTITY	Hydroxychloroquine protects the annexin_A5 anticoagulant shield from disruption by antiphospholipid antibodies : evidence for a novel effect for an old antimalarial drug .
21871597	0	Hydroxychloroquine	0,18	annexin_A5	103,113	Hydroxychloroquine	annexin A5	MESH:D006886	308	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|amod|END_ENTITY	Hydroxychloroquine reduces binding of antiphospholipid antibodies to syncytiotrophoblasts and restores annexin_A5 expression .
26437446	0	Hydroxyflutamide	0,16	connexin_43	25,36	Hydroxyflutamide	connexin 43	MESH:C014290	24392(Tax:10116)	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|END_ENTITY	Hydroxyflutamide affects connexin_43 via the activation of PI3K/Akt-dependent pathway but has no effect on the crosstalk between PI3K/Akt and ERK1/2 pathways at the Raf-1 kinase level in primary rat Sertoli cells .
15451060	0	Hydroxyl	0,8	cytochrome_c	30,42	Hydroxyl	cytochrome c	MESH:D017665	54205	Chemical	Gene	oxidation|amod|START_ENTITY oxidation|nmod|END_ENTITY	Hydroxyl radical oxidation of cytochrome_c by aerobic radiolysis .
24462868	0	Hydroxylamine	0,13	insulin_receptor_substrate_1	95,123	Hydroxylamine	insulin receptor substrate 1	MESH:D019811	16367(Tax:10090)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|activation activation|nmod|END_ENTITY	Hydroxylamine enhances glucose uptake in C2C12 skeletal muscle cells through the activation of insulin_receptor_substrate_1 .
4830258	0	Hydroxyproline	0,14	bradykinin	26,36	Hydroxyproline	bradykinin	CHEBI:18095	3827	Chemical	Gene	analogs|amod|START_ENTITY analogs|nmod|END_ENTITY	Hydroxyproline analogs of bradykinin .
20542424	0	Hydroxysafflor_Yellow_A	0,23	thrombin	35,43	Hydroxysafflor Yellow A	thrombin	MESH:C085278	29251(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|generation generation|amod|END_ENTITY	Hydroxysafflor_Yellow_A suppresses thrombin generation and inflammatory responses following focal cerebral_ischemia-reperfusion in rats .
27086971	0	Hydroxysafflor_yellow_A	0,23	BDNF	34,38	Hydroxysafflor yellow A	BDNF	MESH:C085278	24225(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Hydroxysafflor_yellow_A increases BDNF and NMDARs in the hippocampus in A vascular_dementia rat model .
22745065	0	Hydroxysafflor_yellow_A	0,23	ERK5	103,107	Hydroxysafflor yellow A	ERK5	MESH:C085278	114509(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|advcl|inhibiting inhibiting|dobj|signaling signaling|compound|END_ENTITY	Hydroxysafflor_yellow_A attenuates carbon_tetrachloride-induced hepatic_fibrosis in rats by inhibiting ERK5 signaling .
18717335	0	Hydroxysafflor_yellow_A	1,24	HIF-1alpha	38,48	Hydroxysafflor yellow A	HIF-1alpha	MESH:C085278	3091	Chemical	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|END_ENTITY	-LSB- Hydroxysafflor_yellow_A up-regulates HIF-1alpha via inhibition of VHL and p53 in Eahy 926 cell line exposed to hypoxia -RSB- .
18848665	0	Hydroxytyrosol	0,14	norepinephrine_transporter	25,51	Hydroxytyrosol	norepinephrine transporter	MESH:C005975	83511(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|function function|compound|END_ENTITY	Hydroxytyrosol increases norepinephrine_transporter function in pheochromocytoma cells .
26053062	0	Hydroxyurea	69,80	BCL11A	97,103	Hydroxyurea	BCL11A	MESH:D006918	53335	Chemical	Gene	Associated|compound|START_ENTITY Associated|nmod|END_ENTITY	Variation in Gamma-Globin Expression before and after Induction with Hydroxyurea Associated with BCL11A , KLF1 and TAL1 .
27056246	0	Hydroxyurea	0,11	BCL11A	27,33	Hydroxyurea	BCL11A	MESH:D006918	53335	Chemical	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|END_ENTITY	Hydroxyurea down-regulates BCL11A , KLF-1 and MYB through miRNA-mediated actions to induce y-globin expression : implications for new therapeutic approaches of sickle_cell_disease .
16049920	0	Hydroxyurea	0,11	SMN2	21,25	Hydroxyurea	SMN2	MESH:D006918	6607	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	Hydroxyurea enhances SMN2 gene expression in spinal_muscular_atrophy cells .
12931135	0	Hydroxyurea	0,11	endothelin-1	26,38	Hydroxyurea	endothelin-1	MESH:D006918	1906	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	Hydroxyurea downregulates endothelin-1 gene expression and upregulates ICAM-1 gene expression in cultured human endothelial cells .
24836177	0	Hydroxyurea	0,11	p53	123,126	Hydroxyurea	p53	MESH:D006918	22060(Tax:10090)	Chemical	Gene	Induces|nsubj|START_ENTITY Induces|nmod|Acetylation Acetylation|nmod|END_ENTITY	Hydroxyurea Induces a Hypersensitive Apoptotic Response in Mouse Embryonic Stem Cells Through p38-Dependent Acetylation of p53 .
11513327	0	Hyperbaric_O2	0,13	TNF-alpha	62,71	Hyperbaric O2	TNF-alpha	null	24835(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|production production|amod|END_ENTITY	Hyperbaric_O2 reduces intestinal_ischemia-reperfusion-induced TNF-alpha production and lung neutrophil sequestration .
21998731	0	Hyperforin	0,10	Akt1	20,24	Hyperforin	Akt1	MESH:C001654	207	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Hyperforin inhibits Akt1 kinase activity and promotes caspase-mediated apoptosis involving Bad and Noxa activation in human myeloid_tumor cells .
15622447	0	Hyperforin	0,10	IL-8	61,65	Hyperforin	IL-8	MESH:C001654	3576	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Hyperforin , the active component of St. John 's wort , induces IL-8 expression in human intestinal epithelial cells via a MAPK-dependent , NF-kappaB-independent pathway .
16467866	0	Hyperforin	0,10	MMP-9	20,25	Hyperforin	MMP-9	MESH:C001654	4318	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|compound|END_ENTITY	Hyperforin inhibits MMP-9 secretion by B-CLL cells and microtubule formation by endothelial cells .
17289834	0	Hyperforin	0,10	matrix_metalloproteinase-9	43,69	Hyperforin	matrix metalloproteinase-9	MESH:C001654	4318	Chemical	Gene	blocks|nsubj|START_ENTITY blocks|dobj|activation activation|nmod|END_ENTITY	Hyperforin blocks neutrophil activation of matrix_metalloproteinase-9 , motility and recruitment , and restrains inflammation-triggered angiogenesis and lung_fibrosis .
24252909	0	Hyperoside	0,10	receptor_for_advanced_glycation_end_products	29,73	Hyperoside	receptor for advanced glycation end products	MESH:C021304	177	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	Hyperoside downregulates the receptor_for_advanced_glycation_end_products -LRB- RAGE -RRB- and promotes proliferation in ECV304 cells via the c-Jun_N-terminal_kinases -LRB- JNK -RRB- pathway following stimulation by advanced glycation end-products in vitro .
11640916	0	Hypochlorous_acid	0,17	GST_P1-1	43,51	Hypochlorous acid	GST P1-1	MESH:D006997	2950	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Hypochlorous_acid is a potent inhibitor of GST_P1-1 .
9799559	0	Hypochlorous_acid	0,17	p53	57,60	Hypochlorous acid	p53	MESH:D006997	7157	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Hypochlorous_acid activates the tumor suppressor protein p53 in cultured human skin fibroblasts .
23643651	0	Hypocretin	0,10	HCRT	49,53	Hypocretin	HCRT	MESH:C110857	3060	Chemical	Gene	_|compound|START_ENTITY _|appos|END_ENTITY	Hypocretin _ -LRB- orexin -RRB- _ neuropeptide_precursor gene , HCRT , polymorphisms in early-onset narcolepsy with cataplexy .
590655	0	Hypoglycin	0,10	insulin	22,29	Hypoglycin	insulin	MESH:C041757	100009181(Tax:9986)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|compound|END_ENTITY	Hypoglycin stimulates insulin secretion .
26371861	0	Hypothemycin	0,12	tumor_necrosis_factor-a	22,45	Hypothemycin	tumor necrosis factor-a	MESH:C120440	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Hypothemycin inhibits tumor_necrosis_factor-a production by tristetraprolin-dependent down-regulation of mRNA stability in lipopolysaccharide-stimulated macrophages .
26593410	0	Hypoxanthine	10,22	ENT1	73,77	Hypoxanthine	ENT1	MESH:D019271	2030	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|Activity Activity|nmod|END_ENTITY	Effect of Hypoxanthine on Functional Activity of Nucleoside Transporters ENT1 and ENT2 in Caco-2 Polar Epithelial Intestinal Cells .
16504657	0	Hypoxanthine	0,12	catalase	51,59	Hypoxanthine	catalase	MESH:D019271	847	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|amod|END_ENTITY	Hypoxanthine as a graft ischemia marker stimulates catalase activity in the renal vein during reperfusion in humans .
24859008	0	I-BET151	0,8	IL-6	31,35	I-BET151	IL-6	MESH:C568713	16193(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|compound|END_ENTITY	I-BET151 selectively regulates IL-6 production .
6337313	0	I-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine	28,76	renin	87,92	I-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine	renin	null	24715(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Antihypertensive effects of I-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine on plasma renin activity and catecholamine responses in spontaneously hypertensive rats .
12672912	0	I3C	28,31	PC3	49,52	I3C	PC3	null	3853	Chemical	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	Gene expression profiles of I3C - and DIM-treated PC3 human prostate_cancer cells determined by cDNA microarray analysis .
26318106	0	IAXO-102	40,48	TLR4	23,27	IAXO-102	TLR4	null	7099	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	A novel small molecule TLR4 antagonist -LRB- IAXO-102 -RRB- negatively regulates non-hematopoietic toll_like_receptor_4 signalling and inhibits aortic_aneurysms development .
10437623	0	IBMX	32,36	TNF-alpha	48,57	IBMX	TNF-alpha	MESH:D015056	7124	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	The phosphodiesterase inhibitor IBMX suppresses TNF-alpha expression in human adipocyte precursor cells : a possible explanation for its adipogenic effect .
12101267	4	IBMX	611,615	TNF-alpha	676,685	IBMX	TNF-alpha	MESH:D015056	7124	Chemical	Gene	inhibitor|appos|START_ENTITY presence|nmod|inhibitor reversed|nsubj|presence reversed|dobj|effects effects|amod|END_ENTITY	The presence of a phosphodiesterase -LRB- PDE -RRB- inhibitor -LRB- IBMX -RRB- and cAMP analogs -LRB- 8Br-cAMP , Db-cAMP -RRB- reversed the observed TNF-alpha effects .
7545278	4	IBMX	720,724	cAMP	745,749	IBMX	ET-1	MESH:D015056	1906	Chemical	Gene	production|amod|START_ENTITY production|compound|END_ENTITY	Basal cAMP content , IBMX - and PTH-stimulated cAMP production were unaffected by ET-1 -LRB- 10 -LRB- -8 -RRB- M -RRB- .
26665394	0	IBUPROFEN	14,23	bFGF	27,31	IBUPROFEN	bFGF	MESH:D007052	2247	Chemical	Gene	EFFECT|nmod|START_ENTITY EFFECT|nmod|END_ENTITY	THE EFFECT OF IBUPROFEN ON bFGF , VEGF SECRETION AND CELL PROLIFERATION IN THE PRESENCE OF LPS IN HMEC-1 CELLS .
23238536	0	ICA-105574	30,40	hERG	14,18	ICA-105574	hERG	MESH:C576778	2078	Chemical	Gene	activator|appos|START_ENTITY activator|amod|END_ENTITY	Effects of an hERG activator , ICA-105574 , on electrophysiological properties of canine hearts .
7913381	0	ICI-215001	57,67	beta_2-adrenoceptor	12,31	ICI-215001	beta 2-adrenoceptor	MESH:C076355	100722663	Chemical	Gene	activities|nmod|START_ENTITY activities|amod|END_ENTITY	Beta 1 - and beta_2-adrenoceptor antagonist activities of ICI-215001 , a putative beta_3-adrenoceptor agonist .
890012	0	ICIG_1163	44,53	rpcnu	37,42	ICIG 1163	rpcnu	MESH:C023479	66368(Tax:10090)	Chemical	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of the nitrosourea derivative rpcnu -LRB- ICIG_1163 -RRB- on the development of Friend_leukemia in mice .
3320184	0	ICI_118551	87,97	beta_2_adrenoceptor	55,74	ICI 118551	beta 2 adrenoceptor	MESH:C026777	154	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	A double-blind placebo controlled trial of a selective beta_2_adrenoceptor antagonist -LRB- ICI_118551 -RRB- in chronic anxiety .
2942018	0	ICI_118630	35,45	LH-RH	20,25	ICI 118630	LH-RH	MESH:D017273	2796	Chemical	Gene	-RSB-|compound|START_ENTITY agonist|appos|-RSB- agonist|amod|END_ENTITY	-LSB- Phase I study with LH-RH agonist , ICI_118630 -RSB- .
6230077	0	ICI_118630	111,121	luteinizing-hormone-releasing_hormone	52,89	ICI 118630	luteinizing-hormone-releasing hormone	MESH:D017273	25194(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Stimulation of cholesterol side-chain cleavage by a luteinizing-hormone-releasing_hormone -LRB- luliberin -RRB- agonist -LRB- ICI_118630 -RRB- in rat Leydig cells .
380618	0	ICI_118630	24,34	luteinizing_hormone-releasing_hormone	49,86	ICI 118630	luteinizing hormone-releasing hormone	MESH:D017273	25194(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Anti-tumour activity of ICI_118630 , a new potent luteinizing_hormone-releasing_hormone agonist .
6324760	0	ICI_118630	70,80	luteinizing_hormone-releasing_hormone	23,60	ICI 118630	luteinizing hormone-releasing hormone	MESH:D017273	25194(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	The role of calcium in luteinizing_hormone-releasing_hormone agonist -LRB- ICI_118630 -RRB- - stimulated steroidogenesis in rat Leydig cells .
2823997	0	ICI_174864	72,82	neurotensin	14,25	ICI 174864	neurotensin	MESH:C040643	299757(Tax:10116)	Chemical	Gene	antagonist|dobj|START_ENTITY antagonist|nsubj|effect effect|nmod|END_ENTITY	The effect of neurotensin , TRH and the delta-opioid receptor antagonist ICI_174864 on alcohol-induced narcosis in rats .
12161509	0	ICI_182780	51,61	CRH	83,86	ICI 182780	CRH	MESH:C070081	1392	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	Estrogen represses whereas the estrogen-antagonist ICI_182780 stimulates placental CRH gene expression .
15743524	0	ICI_182780	11,21	estrogen_receptor	25,42	ICI 182780	estrogen receptor	MESH:C070081	2099	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of ICI_182780 on estrogen_receptor expression , fluid absorption and sperm motility in the epididymis of the bonnet monkey .
9816164	0	ICI_182780	88,98	insulin-like_growth_factor_I	14,42	ICI 182780	insulin-like growth factor I	MESH:C070081	3479	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of insulin-like_growth_factor_I receptor expression by the pure antiestrogen ICI_182780 .
8930399	0	ICI_182780	108,118	insulin-like_growth_factor_binding_protein_5	11,55	ICI 182780	insulin-like growth factor binding protein 5	MESH:C070081	3488	Chemical	Gene	action|nmod|START_ENTITY role|nmod|action role|nmod|END_ENTITY	A role for insulin-like_growth_factor_binding_protein_5 in the antiproliferative action of the antiestrogen ICI_182780 .
1596289	0	ICI_D1694	27,36	thymidylate_synthase	78,98	ICI D1694	thymidylate synthase	MESH:C068874	22171(Tax:10090)	Chemical	Gene	characteristics|nmod|START_ENTITY characteristics|dep|antifolate antifolate|acl:relcl|inhibits inhibits|xcomp|END_ENTITY	Kinetic characteristics of ICI_D1694 : a quinazoline antifolate which inhibits thymidylate_synthase .
1913676	0	ICI_D1694	0,9	thymidylate_synthase	36,56	ICI D1694	thymidylate synthase	MESH:C068874	22171(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	ICI_D1694 , a quinazoline antifolate thymidylate_synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo : a new agent for clinical study .
7680860	0	ICI_D1694	84,93	thymidylate_synthase	52,72	ICI D1694	thymidylate synthase	MESH:C068874	22171(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	The measurement of polyglutamate metabolites of the thymidylate_synthase inhibitor , ICI_D1694 , in mouse and human cultured cells .
1334748	0	ICI_D2138	29,38	5-lipoxygenase	86,100	ICI D2138	5-lipoxygenase	MESH:C075799	240	Chemical	Gene	pharmacology|nmod|START_ENTITY pharmacology|appos|inhibitor inhibitor|nmod|END_ENTITY	Pre-clinical pharmacology of ICI_D2138 , a potent orally-active non-redox inhibitor of 5-lipoxygenase .
8395247	0	ICI_D2138	65,74	5-lipoxygenase	127,141	ICI D2138	5-lipoxygenase	MESH:C075799	240	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Structure and activity relationships leading to the discovery of ICI_D2138 , a selective , potent and orally active inhibitor of 5-lipoxygenase .
7800658	0	ICI_D7114	33,42	beta_3-adrenoceptor	56,75	ICI D7114	beta 3-adrenoceptor	MESH:C071909	25645(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Effect of chronic treatment with ICI_D7114 , a selective beta_3-adrenoceptor agonist , on macronutrient selection and brown adipose tissue thermogenesis in Sprague-Dawley_rats .
12832072	0	ICRF-193	116,124	DNA_topoisomerase_IIbeta	58,82	ICRF-193	DNA topoisomerase IIbeta	MESH:C070899	7155	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	The SUMO pathway is required for selective degradation of DNA_topoisomerase_IIbeta induced by a catalytic inhibitor ICRF-193 -LRB- 1 -RRB- .
8089930	0	IFO	42,45	monoamine_oxidase-B	78,97	IFO	monoamine oxidase-B	null	109731(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	A study of the biological pharmacology of IFO , a new selective and reversible monoamine_oxidase-B inhibitor .
16762314	0	IK682	0,5	TACE	36,40	IK682	TACE	MESH:C468787	6868	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	IK682 , a tight binding inhibitor of TACE .
12006511	0	IMC-C225	89,97	CPT-11	130,136	IMC-C225	CPT-11	null	963084(Tax:115711)	Chemical	Gene	activity|nmod|START_ENTITY activity|appos|END_ENTITY	Enhanced antitumor activity of anti-epidermal_growth_factor_receptor monoclonal antibody IMC-C225 in combination with irinotecan -LRB- CPT-11 -RRB- against human colorectal_tumor xenografts .
10897003	0	IMC-C225	54,62	Epidermal_growth_factor_receptor	0,32	IMC-C225	Epidermal growth factor receptor	null	1956	Chemical	Gene	blockade|nmod|START_ENTITY blockade|amod|END_ENTITY	Epidermal_growth_factor_receptor blockade by antibody IMC-C225 inhibits growth of a human pancreatic_carcinoma xenograft in nude_mice .
18849610	0	IMD-0354	86,94	I_kappaB_kinase_beta	54,74	IMD-0354	I kappaB kinase beta	MESH:C492919	16150(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Antiallergic and anti-inflammatory effects of a novel I_kappaB_kinase_beta inhibitor , IMD-0354 , in a mouse model of allergic_inflammation .
15561889	0	IMD-0354	29,37	NF-kappaB	8,17	IMD-0354	NF-kappaB	MESH:C492919	4790	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	A novel NF-kappaB inhibitor , IMD-0354 , suppresses neoplastic proliferation of human mast cells with constitutively activated c-kit receptors .
18421620	0	IN-1130	78,85	ALK5	127,131	IN-1130	ALK5	MESH:C530153	7046	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|appos|END_ENTITY	Identification of human cytochrome_P450 enzymes involved in the metabolism of IN-1130 , a novel activin_receptor-like_kinase-5 -LRB- ALK5 -RRB- inhibitor .
18421620	0	IN-1130	78,85	activin_receptor-like_kinase-5	95,125	IN-1130	activin receptor-like kinase-5	MESH:C530153	7046	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Identification of human cytochrome_P450 enzymes involved in the metabolism of IN-1130 , a novel activin_receptor-like_kinase-5 -LRB- ALK5 -RRB- inhibitor .
20308445	0	IN-1233	0,7	ALK-5	12,17	IN-1233	ALK-5	MESH:C538835	29591(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	IN-1233 , an ALK-5 inhibitor : prevention of granulation tissue formation after bare metallic stent placement in a rat urethral model .
26138303	0	INC280	0,6	c-MET	56,61	INC280	c-MET	null	4233	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	INC280 , an orally available small molecule inhibitor of c-MET , reduces migration and adhesion in ovarian cancer cell models .
26138303	0	INC280	0,6	c-MET	56,61	INC280	c-MET	null	4233	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	INC280 , an orally available small molecule inhibitor of c-MET , reduces migration and adhesion in ovarian cancer cell models .
20373256	0	INCB-13739	0,10	11beta-hydroxysteroid_dehydrogenase_type_1	15,57	INCB-13739	11beta-hydroxysteroid dehydrogenase type 1	MESH:C552933	3290	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	INCB-13739 , an 11beta-hydroxysteroid_dehydrogenase_type_1 inhibitor for the treatment of type 2 diabetes .
20843246	0	INCB018424	23,33	JAK1	37,41	INCB018424	JAK1	MESH:C540383	3716	Chemical	Gene	Safety|nmod|START_ENTITY Safety|appos|inhibitor inhibitor|compound|END_ENTITY	Safety and efficacy of INCB018424 , a JAK1 and JAK2 inhibitor , in myelofibrosis .
20072651	0	INCB16562	0,9	JAK1/2	13,19	INCB16562	JAK1/2	MESH:C549231	3716	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	INCB16562 , a JAK1/2 selective inhibitor , is efficacious against multiple_myeloma cells and reverses the protective effects of cytokine and stromal cell support .
16210643	0	INCB3344	89,97	CCR2	72,76	INCB3344	CCR2	MESH:C505875	12772(Tax:10090)	Chemical	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Discovery and pharmacological characterization of a novel rodent-active CCR2 antagonist , INCB3344 .
19576173	0	INCB3344	36,44	CCR2	83,87	INCB3344	CCR2	MESH:C505875	729230	Chemical	Gene	characterization|nmod|START_ENTITY characterization|appos|antagonist antagonist|nmod|END_ENTITY	Pharmacological characterization of INCB3344 , a small molecule antagonist of human CCR2 .
21036044	0	INCB3344	13,21	CCR2	98,102	INCB3344	CCR2	MESH:C505875	12772(Tax:10090)	Chemical	Gene	Discovery|nmod|START_ENTITY Discovery|appos|antagonist antagonist|nmod|END_ENTITY	Discovery of INCB3344 , a potent , selective and orally bioavailable antagonist of human and murine CCR2 .
22205983	0	INCB3344	95,103	CCR2	78,82	INCB3344	CCR2	MESH:C505875	12772(Tax:10090)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	Suppression and regression of choroidal_neovascularization in mice by a novel CCR2 antagonist , INCB3344 .
25990456	0	INK-128	39,46	mTORC1	18,24	INK-128	mTORC1	MESH:C572449	382056(Tax:10090)	Chemical	Gene	Dual|nmod|START_ENTITY Dual|nmod|END_ENTITY	Dual targeting of mTORC1 and mTORC2 by INK-128 potently inhibits human prostate_cancer cell growth in vitro and in vivo .
27031383	0	ION-353382	54,64	Alpha-2-Macroglobulin	107,128	ION-353382	Alpha-2-Macroglobulin	null	232345(Tax:10090)	Chemical	Gene	Investigations|nmod|START_ENTITY Investigations|dep|END_ENTITY	Pharmacokinetic and Pharmacodynamic Investigations of ION-353382 , a Model Antisense Oligonucleotide : Using Alpha-2-Macroglobulin and Murinoglobulin Double-Knockout Mice .
21737509	0	IPI-493	27,34	HSP90	10,15	IPI-493	HSP90	MESH:C112765	3320	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	The Novel HSP90 inhibitor , IPI-493 , is highly effective in human gastrostrointestinal_stromal_tumor xenografts carrying heterogeneous KIT mutations .
17624530	0	IPI-504	0,7	HSP-90	29,35	IPI-504	HSP-90	MESH:C112765	3320	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	IPI-504 , a novel and soluble HSP-90 inhibitor , blocks the unfolded protein response in multiple_myeloma cells .
20940188	0	IPI-504	12,19	heat-shock_protein_90	29,50	IPI-504	heat-shock protein 90	MESH:C112765	3320	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Activity of IPI-504 , a novel heat-shock_protein_90 inhibitor , in patients with molecularly defined non-small-cell_lung_cancer .
19671750	0	IPI-504	22,29	heat_shock_protein_90	43,64	IPI-504	heat shock protein 90	MESH:C112765	3320	Chemical	Gene	efficacy|nmod|START_ENTITY efficacy|appos|inhibitor inhibitor|amod|END_ENTITY	Antitumor efficacy of IPI-504 , a selective heat_shock_protein_90 inhibitor against human epidermal_growth_factor_receptor_2-positive human xenograft models as a single agent and in combination with trastuzumab or lapatinib .
19065668	0	IRC-083864	0,10	CDC25	45,50	IRC-083864	CDC25	MESH:C535248	995	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	IRC-083864 , a novel bis quinone inhibitor of CDC25 phosphatases active against human cancer cells .
21959172	0	IRL-1620	31,39	Endothelin_B_receptor	0,21	IRL-1620	Endothelin B receptor	MESH:C074308	50672(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Endothelin_B_receptor agonist , IRL-1620 , reduces neurological_damage following permanent middle_cerebral_artery_occlusion in rats .
22580085	0	IRL-1620	31,39	Endothelin_B_receptor	0,21	IRL-1620	Endothelin B receptor	MESH:C074308	50672(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Endothelin_B_receptor agonist , IRL-1620 , provides long-term neuroprotection in cerebral_ischemia in rats .
23850649	0	IRL-1620	31,39	Endothelin_B_receptor	0,21	IRL-1620	Endothelin B receptor	MESH:C074308	50672(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Endothelin_B_receptor agonist , IRL-1620 , enhances angiogenesis and neurogenesis following cerebral_ischemia in rats .
7791103	0	IRL1620	126,133	ETA	80,83	IRL1620	ETA	MESH:C074308	24326(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	Regulation of ion transport by endothelins in rat colonic mucosa : effects of an ETA antagonist -LRB- FR139317 -RRB- and an ETB agonist -LRB- IRL1620 -RRB- .
8449230	0	IRL_1038	25,33	ETB	0,3	IRL 1038	ETB	MESH:C077420	50672(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	ETB receptor antagonist , IRL_1038 , selectively inhibits the endothelin-induced endothelium-dependent vascular relaxation .
7849060	0	IRL_1620	84,92	ETB	97,100	IRL 1620	ETB	MESH:C074308	1910	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	1H NMR studies of sarafotoxin SRTb , a nonselective endothelin receptor agonist , and IRL_1620 , an ETB receptor-specific agonist .
16244791	0	IRL_1620	31,39	Endothelin_B_receptor	0,21	IRL 1620	Endothelin B receptor	MESH:C074308	50672(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Endothelin_B_receptor agonist , IRL_1620 , enhances the anti-tumor efficacy of paclitaxel in breast_tumor rats .
7957593	0	IRL_1620	37,45	endothelin_ETB_receptor	4,27	IRL 1620	endothelin ETB receptor	MESH:C074308	100009477(Tax:9986)	Chemical	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	The endothelin_ETB_receptor agonist , IRL_1620 , causes vasodilatation and inhibits ex vivo platelet_aggregation in the anaesthetised rabbit .
8587424	0	IRL_2500	77,85	endothelin-B_receptor	43,64	IRL 2500	endothelin-B receptor	MESH:C098287	50672(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Characterization of a potent and selective endothelin-B_receptor antagonist , IRL_2500 .
18443121	0	IS1008	63,69	blaOXA-58	31,40	IS1008	blaOXA-58	null	6155789(Tax:470)	Chemical	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Acquisition of a plasmid-borne blaOXA-58 gene with an upstream IS1008 insertion conferring a high level of carbapenem resistance to Acinetobacter_baumannii .
15992159	0	ISIS_2302	0,9	intercellular_adhesion_molecule_1	37,70	ISIS 2302	intercellular adhesion molecule 1	MESH:C089753	3383	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	ISIS_2302 , an antisense inhibitor of intercellular_adhesion_molecule_1 .
20485865	0	ISO-1	0,5	macrophage_migration_inhibitory_factor	9,47	ISO-1	macrophage migration inhibitory factor	null	17319(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	ISO-1 , a macrophage_migration_inhibitory_factor antagonist , inhibits airway remodeling in a murine model of chronic_asthma .
24594933	0	ISU201	50,56	BST2	111,115	ISU201	BST2	null	684	Chemical	Gene	START_ENTITY|appos|form form|nmod|END_ENTITY	Anti-inflammatory and anti-remodelling effects of ISU201 , a modified form of the extracellular domain of human BST2 , in experimental models of asthma : association with inhibition of histone acetylation .
19933214	0	ITE	43,46	AhR	31,34	ITE	AhR	null	11622(Tax:10090)	Chemical	Gene	ligand|advmod|START_ENTITY ligand|nsubj|END_ENTITY	TCDD and a putative endogenous AhR ligand , ITE , elicit the same immediate changes in gene expression in mouse lung fibroblasts .
20300007	0	ITF2357	34,41	CXCR4	60,65	ITF2357	CXCR4	MESH:C502418	7852	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|END_ENTITY	The histone deacetylase inhibitor ITF2357 decreases surface CXCR4 and CCR5 expression on CD4 -LRB- + -RRB- T-cells and monocytes and is superior to valproic_acid for latent HIV-1 expression in vitro .
19542681	0	ITZ-1	28,33	matrix_metalloproteinase-13	69,96	ITZ-1	matrix metalloproteinase-13	null	4322	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	The chondroprotective agent ITZ-1 inhibits interleukin-1beta-induced matrix_metalloproteinase-13 production and suppresses nitric_oxide-induced chondrocyte death .
9736913	0	IT_9302	0,7	interleukin-10	21,35	IT 9302	interleukin-10	MESH:C114519	100008701(Tax:9986)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	IT_9302 , a synthetic interleukin-10 agonist , diminishes acute_lung_injury in rabbits with acute_necrotizing_pancreatitis .
11198353	0	IV-TPN	45,51	ICAM-1	20,26	IV-TPN	ICAM-1	null	15894(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Modulation of organ ICAM-1 expression during IV-TPN with glutamine and bombesin .
3079804	0	Ia	27,29	IFN-gamma	110,119	Ia	IFN-gamma	null	15978(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Differential expression of Ia and Ia-associated_invariant_chain in mouse tissues after in vivo treatment with IFN-gamma .
22525315	0	Ianthellamide_A	0,15	kynurenine-3-hydroxylase	29,53	Ianthellamide A	kynurenine-3-hydroxylase	null	59113(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Ianthellamide_A , a selective kynurenine-3-hydroxylase inhibitor from the Australian marine sponge Ianthella quadrangulata .
25911186	0	Ibandronate	0,11	sclerostin	22,32	Ibandronate	sclerostin	MESH:C073007	50964	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|amod|END_ENTITY	Ibandronate increases sclerostin levels and bone strength in male patients with idiopathic_osteoporosis .
22200647	0	Ibogaine	0,8	acetylcholinesterase	31,51	Ibogaine	acetylcholinesterase	MESH:D007050	43	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Ibogaine and the inhibition of acetylcholinesterase .
2996714	0	Ibotenic_acid	0,13	thyrotropin-releasing_hormone_receptor	24,62	Ibotenic acid	thyrotropin-releasing hormone receptor	MESH:D007051	25570(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|END_ENTITY	Ibotenic_acid decreases thyrotropin-releasing_hormone_receptor binding in the rat amygdala .
24659631	0	Ibrutinib	0,9	BCR	19,22	Ibrutinib	BCR	MESH:C551803	613	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dep|signaling signaling|nsubj|END_ENTITY	Ibrutinib inhibits BCR and NF-kB signaling and reduces tumor proliferation in tissue-resident cells of patients with CLL .
26348529	0	Ibrutinib	31,40	BTK	14,17	Ibrutinib	BTK	MESH:C551803	12229(Tax:10090)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of BTK and ITK with Ibrutinib Is Effective in the Prevention of Chronic_Graft-versus-Host_Disease in Mice .
26348529	0	Ibrutinib	31,40	BTK	14,17	Ibrutinib	BTK	MESH:C551803	12229(Tax:10090)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of BTK and ITK with Ibrutinib Is Effective in the Prevention of Chronic_Graft-versus-Host_Disease in Mice .
25565020	0	Ibrutinib	0,9	p65	36,39	Ibrutinib	p65	MESH:C551803	5970	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Ibrutinib inhibits BTK-driven NF-kB p65 activity to overcome bortezomib-resistance in multiple myeloma .
26859874	0	Ibudilast	52,61	Toll-Like_Receptor_4	19,39	Ibudilast	Toll-Like Receptor 4	MESH:C038366	29260(Tax:10116)	Chemical	Gene	Antagonist|appos|START_ENTITY Antagonist|compound|END_ENTITY	The Effects of the Toll-Like_Receptor_4 Antagonist , Ibudilast , on Sevoflurane 's Minimum Alveolar Concentration and the Delayed Remifentanil-Induced Increase in the Minimum Alveolar Concentration in Rats .
18374906	0	Ibuprofen	0,9	Abeta	18,23	Ibuprofen	Abeta	MESH:D007052	14961(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	Ibuprofen reduces Abeta , hyperphosphorylated tau_and_memory_deficits in Alzheimer_mice .
26424593	0	Ibuprofen	7,16	Farnesoid_X_Receptor	67,87	Ibuprofen	Farnesoid X Receptor	MESH:D007052	9971	Chemical	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	NSAIDs Ibuprofen , Indometacin , and Diclofenac do not interact with Farnesoid_X_Receptor .
21931204	0	Ibuprofen	10,19	IL-1b	23,28	Ibuprofen	IL-1b	MESH:D007052	3553	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Effect of Ibuprofen on IL-1b , TNF-a and PGE2 levels in periapical exudates : a double blinded clinical trial .
25542161	0	Ibuprofen	64,73	S-100B	92,98	Ibuprofen	S-100B	MESH:D007052	6285	Chemical	Gene	START_ENTITY|nmod|Release Release|nmod|END_ENTITY	Impact of Patent Ductus Arter osus and Subsequent Therapy with Ibuprofen on The Release of S-100B and Ox dat ve Stress Index in Preterm Infants .
8649201	0	Ibuprofen	0,9	VCAM-1	51,57	Ibuprofen	VCAM-1	MESH:D007052	7412	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Ibuprofen inhibits pyrogen-dependent expression of VCAM-1 and ICAM-1 on human endothelial cells .
9246021	0	Ibuprofen	0,9	beta-endorphin	34,48	Ibuprofen	beta-endorphin	MESH:D007052	5443	Chemical	Gene	elevates|nsubj|START_ENTITY elevates|dobj|levels levels|amod|END_ENTITY	Ibuprofen elevates immunoreactive beta-endorphin levels in humans during surgical stress .
20726987	0	Ibuprofen	0,9	hPEPT1	116,122	Ibuprofen	hPEPT1	MESH:D007052	6564	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|hPEPT1 hPEPT1|dep|interactions interactions|nmod|substrates substrates|amod|END_ENTITY	Ibuprofen is a non-competitive inhibitor of the peptide transporter hPEPT1 -LRB- SLC15A1 -RRB- : possible interactions between hPEPT1 substrates and ibuprofen .
20726987	0	Ibuprofen	0,9	hPEPT1	68,74	Ibuprofen	hPEPT1	MESH:D007052	6564	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Ibuprofen is a non-competitive inhibitor of the peptide transporter hPEPT1 -LRB- SLC15A1 -RRB- : possible interactions between hPEPT1 substrates and ibuprofen .
9406924	0	Ibuprofen	0,9	inducible_nitric_oxide_synthase	21,52	Ibuprofen	inducible nitric oxide synthase	MESH:D007052	24599(Tax:10116)	Chemical	Gene	START_ENTITY|dep|effect effect|nmod|END_ENTITY	Ibuprofen : effect on inducible_nitric_oxide_synthase .
1757329	0	Ibuprofen	0,9	tumor_necrosis_factor	28,49	Ibuprofen	tumor necrosis factor	MESH:D007052	397086(Tax:9823)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|activity activity|compound|END_ENTITY	Ibuprofen attenuates plasma tumor_necrosis_factor activity during sepsis-induced acute_lung_injury .
24550686	0	Icariin	0,7	APP	36,39	Icariin	APP	MESH:C056599	11820(Tax:10090)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|nmod|END_ENTITY	Icariin decreases the expression of APP and BACE-1 and reduces the b-amyloid burden in an APP transgenic mouse model of Alzheimer 's _ disease .
24940396	0	Icariin	0,7	JNK	139,142	Icariin	JNK	MESH:C056599	116554(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|nmod|END_ENTITY	Icariin attenuates angiotensin_II-induced hypertrophy and apoptosis in H9c2 cardiomyocytes by inhibiting reactive oxygen species-dependent JNK and p38 pathways .
25806530	0	Icariin	0,7	NFE2L1	46,52	Icariin	NFE2L1	MESH:C056599	360610(Tax:10116)	Chemical	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	Icariin Induces Synoviolin Expression through NFE2L1 to Protect Neurons from ER Stress-Induced Apoptosis .
17883938	0	Icariin	0,7	PGC-1alpha	31,41	Icariin	PGC-1alpha	MESH:C056599	19017(Tax:10090)	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|nmod|END_ENTITY	Icariin promotes expression of PGC-1alpha , PPARalpha , and NRF-1 during cardiomyocyte differentiation of murine embryonic stem cells in vitro .
19303870	0	Icariin	0,7	SIRT1	86,91	Icariin	SIRT1	MESH:C056599	23411	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Icariin enhances neuronal survival after oxygen_and_glucose_deprivation by increasing SIRT1 .
20533910	0	Icariin	0,7	catalase	99,107	Icariin	catalase	MESH:C056599	847	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Icariin inhibits hydrogen_peroxide-mediated cytotoxicity by up-regulating sirtuin type 1-dependent catalase and peroxiredoxin .
24513083	0	Icariin	0,7	phosphodiesterase-5	11,30	Icariin	phosphodiesterase-5	MESH:C056599	242202(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Icariin , a phosphodiesterase-5 inhibitor , improves learning and memory in APP/PS1 transgenic_mice by stimulation of NO/cGMP signalling .
21538629	0	Icariin	0,7	toll-like_receptor_9	34,54	Icariin	toll-like receptor 9	MESH:C056599	81897(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Icariin induces the expression of toll-like_receptor_9 in ana-1 murine macrophages .
20560114	0	Icaritin	0,8	JNK1	50,54	Icaritin	JNK1	MESH:C499403	5599	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|apoptosis apoptosis|nmod|cells cells|nmod|END_ENTITY	Icaritin induces apoptosis of HepG2 cells via the JNK1 signaling pathway independent of the estrogen_receptor .
22112293	0	Icotinib	0,8	EGFR	30,34	Icotinib	EGFR	MESH:C531470	1956	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Icotinib -LRB- BPI-2009H -RRB- , a novel EGFR tyrosine kinase inhibitor , displays potent efficacy in preclinical studies .
26141219	0	Icotinib	0,8	EGFR	124,128	Icotinib	EGFR	MESH:C531470	1956	Chemical	Gene	effective|nsubj|START_ENTITY effective|nmod|mutations mutations|compound|END_ENTITY	Icotinib might be effective for the treatment of leptomeningeal_carcinomatosis in non-small_cell_lung_cancer with sensitive EGFR mutations .
26980473	0	Icotinib	0,8	EGFR	86,90	Icotinib	EGFR	MESH:C531470	1956	Chemical	Gene	START_ENTITY|nmod|Patients Patients|nmod|Esophageal_Squamous_Cell_Carcinoma Esophageal_Squamous_Cell_Carcinoma|nmod|Overexpression Overexpression|compound|END_ENTITY	Icotinib in Patients with Pretreated Advanced Esophageal_Squamous_Cell_Carcinoma with EGFR Overexpression or EGFR Gene Amplification : A Single-Arm , Multicenter Phase 2 Study .
25675121	0	Icotinib	0,8	EGF_receptor	22,34	Icotinib	EGF receptor	MESH:C531470	1956	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Icotinib , a selective EGF_receptor tyrosine kinase inhibitor , for the treatment of non-small-cell_lung_cancer .
25712626	0	Idelalisib	0,10	PI3K	14,18	Idelalisib	PI3K	MESH:C552946	5293	Chemical	Gene	START_ENTITY|dep|agent agent|compound|END_ENTITY	Idelalisib - a PI3K targeting agent for B-cell malignancies .
26185276	0	Idelalisib	0,10	PI3K	20,24	Idelalisib	PI3K	null	5293	Chemical	Gene	START_ENTITY|dep|Inhibitor Inhibitor|compound|END_ENTITY	Idelalisib : A Novel PI3K Inhibitor for Chronic_Lymphocytic_Leukemia .
19224818	0	Ifenprodil	0,10	NR2B	67,71	Ifenprodil	NR2B	MESH:C010739	24410(Tax:10116)	Chemical	Gene	induced|compound|START_ENTITY induced|acl|antinociception antinociception|dobj|expression expression|nmod|subunits subunits|nummod|END_ENTITY	Ifenprodil induced antinociception and decreased the expression of NR2B subunits in the dorsal horn after chronic dorsal root ganglia compression in rats .
26220217	0	Ifosfamide	44,54	IL-1	21,25	Ifosfamide	IL-1	MESH:D007069	111343(Tax:10090)	Chemical	Gene	Induced|compound|START_ENTITY Induced|compound|END_ENTITY	Target Inhibition of IL-1 Receptor Prevents Ifosfamide Induced Hemorrhagic_Cystitis in Mice .
11145658	0	Ig	57,59	CD40	8,12	Ig	CD40	null	21939(Tax:10090)	Chemical	Gene	production|compound|START_ENTITY Role|nmod|production Role|nmod|END_ENTITY	Role of CD40 in a T cell-mediated negative regulation of Ig production .
21059893	0	Ig	43,45	DREAM	60,65	Ig	DREAM	null	56461(Tax:10090)	Chemical	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Increased B cell proliferation and reduced Ig production in DREAM transgenic_mice .
2212655	0	Ig	36,38	Platelet-activating_factor	0,26	Ig	Platelet-activating factor	null	9768	Chemical	Gene	production|compound|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	Platelet-activating_factor enhances Ig production in B lymphoblastoid cell lines .
1903417	0	Ig	62,64	Transforming_growth_factor-beta	0,31	Ig	Transforming growth factor-beta	null	7040	Chemical	Gene	production|compound|START_ENTITY suppresses|dobj|production suppresses|nsubj|END_ENTITY	Transforming_growth_factor-beta suppresses human B lymphocyte Ig production by inhibiting synthesis and the switch from the membrane form to the secreted form of Ig mRNA .
8666891	4	Ii	730,732	p41	718,721	Ii	p41	null	5594	Chemical	Gene	form|nmod|START_ENTITY form|amod|END_ENTITY	We have previously isolated a noncovalent complex of the lysosomal cysteine protease cathepsin_L with a peptide fragment derived from the p41 form of Ii from human kidney .
19695241	0	Ile-Pro-Ile	23,34	dipeptidyl_peptidase_IV	72,95	Ile-Pro-Ile	dipeptidyl peptidase IV	MESH:C041445	25253(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Intrathecally injected Ile-Pro-Ile , an inhibitor of membrane ectoenzyme dipeptidyl_peptidase_IV , is antihyperalgesic in rats by switching the enzyme from hydrolase to synthase functional mode to generate endomorphin 2 .
18579388	0	Illudalic_acid	0,14	LAR	30,33	Illudalic acid	LAR	MESH:C532762	5792	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|compound|END_ENTITY	Illudalic_acid as a potential LAR inhibitor : synthesis , SAR , and preliminary studies on the mechanism of action .
26905124	0	Imatinib	152,160	BCR-ABL	54,61	Imatinib	BCR-ABL	MESH:C097613	25	Chemical	Gene	resistance|compound|START_ENTITY END_ENTITY|nmod|resistance	Simple multiplex RT-PCR for identifying common fusion BCR-ABL transcript types and evaluation of molecular response of the a2b2 and a2b3 transcripts to Imatinib resistance in north Indian chronic_myeloid_leukemia patients .
16983347	0	Imatinib	0,8	Bcl-2	98,103	Imatinib	Bcl-2	MESH:C097613	596	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|advcl|END_ENTITY	Imatinib enhances human melanoma cell susceptibility to TRAIL-induced cell death : Relationship to Bcl-2 family and caspase activation .
26317515	0	Imatinib	126,134	Bcr-Abl	145,152	Imatinib	Bcr-Abl	MESH:C097613	25	Chemical	Gene	START_ENTITY|nmod|Proliferation Proliferation|compound|END_ENTITY	Ribavirin Inhibits the Activity of mTOR/eIF4E , ERK/Mnk1/eIF4E Signaling Pathway and Synergizes with Tyrosine Kinase Inhibitor Imatinib to Impair Bcr-Abl Mediated Proliferation and Apoptosis in Ph + Leukemia .
20109338	0	Imatinib	91,99	C-KIT	0,5	Imatinib	C-KIT	MESH:C097613	3815	Chemical	Gene	overexpression|nmod|START_ENTITY overexpression|amod|END_ENTITY	C-KIT overexpression and mutation in nasopharyngeal_carcinoma cell lines and reactivity of Imatinib on these cell lines .
22815156	0	Imatinib	61,69	C-KIT	0,5	Imatinib	C-KIT	MESH:C097613	3815	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|mutations mutations|amod|END_ENTITY	C-KIT mutations were closely associated with the response to Imatinib in Chinese advanced gastrointestinal_stromal_tumor patients .
21773872	7	Imatinib	1385,1393	Ccn3	1351,1355	Imatinib	CCN3	MESH:C097613	4856	Chemical	Gene	treated|nmod|START_ENTITY treated|nmod|END_ENTITY	Wild type K562 cells treated with recombinant human Ccn3 -LRB- 10 nM -RRB- in combination with Imatinib -LRB- 5 M -RRB- also displayed enhanced cell kill -LRB- p = 0.008 -RRB- .
22388075	0	Imatinib	0,8	H2AX	17,21	Imatinib	H2AX	MESH:C097613	3014	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Imatinib induces H2AX phosphorylation and apoptosis in chronic_myelogenous_leukemia cells in vitro via caspase-3 / Mst1 pathway .
15725473	0	Imatinib	0,8	KIT	73,76	Imatinib	KIT	MESH:C097613	3815	Chemical	Gene	mesylate|nsubj|START_ENTITY mesylate|nmod|mutations mutations|compound|END_ENTITY	Imatinib mesylate in the treatment of Core_Binding_Factor_leukemias with KIT mutations .
21561667	0	Imatinib	0,8	KIT	139,142	Imatinib	KIT	MESH:C097613	403811(Tax:9615)	Chemical	Gene	elicited|nsubj|START_ENTITY elicited|nmod|mast_cell_tumor mast_cell_tumor|acl|carrying carrying|dobj|mutation mutation|nmod|suppression suppression|nmod|activation activation|compound|END_ENTITY	Imatinib elicited a favorable response in a dog with a mast_cell_tumor carrying a c-kit c. 1523A > T mutation via suppression of constitutive KIT activation .
23567324	1	Imatinib	76,84	KIT	47,50	Imatinib	KIT	MESH:C097613	3815	Chemical	Gene	responds|nmod|START_ENTITY GIST|acl:relcl|responds END_ENTITY|nmod|GIST	A novel double-mutant KIT in GIST that responds to Imatinib .
24687822	0	Imatinib	60,68	KRAS	0,4	Imatinib	KRAS	MESH:C097613	3845	Chemical	Gene	Resistance|compound|START_ENTITY Resistance|compound|END_ENTITY	KRAS and KIT Gatekeeper Mutations Confer Polyclonal Primary Imatinib Resistance in GI Stromal Tumors : Relevance of Concomitant Phosphatidylinositol 3-Kinase/AKT Dysregulation .
15815724	0	Imatinib	0,8	Par-4	70,75	Imatinib	Par-4	MESH:C097613	347745	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|expression expression|nmod|END_ENTITY	Imatinib induces apoptosis in CLL lymphocytes with high expression of Par-4 .
26576593	0	Imatinib	44,52	S0502	0,5	Imatinib	S0502	MESH:C097613	1076938(Tax:198215)	Chemical	Gene	Study|nmod|START_ENTITY Study|dep|END_ENTITY	S0502 : A SWOG Phase III Randomized Study of Imatinib , With or Without Bevacizumab , in Patients With Untreated Metastatic or Unresectable Gastrointestinal_Stromal_Tumors .
18056005	0	Imatinib	0,8	c-KIT	78,83	Imatinib	c-KIT	MESH:C097613	3815	Chemical	Gene	mesylate|nsubj|START_ENTITY mesylate|nmod|treatment treatment|nmod|acute_myeloid_leukemia acute_myeloid_leukemia|amod|END_ENTITY	Imatinib mesylate in the treatment of newly diagnosed or refractory/resistant c-KIT positive acute_myeloid_leukemia .
20339585	0	Imatinib	51,59	c-KIT	20,25	Imatinib	c-KIT	MESH:C097613	3815	Chemical	Gene	Response|compound|START_ENTITY Associated|nmod|Response Associated|nsubj|Mutation Mutation|nmod|Exon Exon|amod|END_ENTITY	A V530I Mutation in c-KIT Exon 10 Is Associated to Imatinib Response in Extraabdominal_Aggressive_Fibromatosis .
24292246	0	Imatinib	0,8	c-KIT	79,84	Imatinib	c-KIT	MESH:C097613	3815	Chemical	Gene	responsiveness|nsubj|START_ENTITY responsiveness|nmod|mast_cell_tumors mast_cell_tumors|acl|carrying carrying|dobj|mutations mutations|nmod|exon exon|compound|END_ENTITY	Imatinib responsiveness in canine mast_cell_tumors carrying novel mutations of c-KIT exon 11 .
15722647	0	Imatinib	0,8	c-Kit	109,114	Imatinib	c-Kit	MESH:C097613	16590(Tax:10090)	Chemical	Gene	blocks|nsubj|START_ENTITY blocks|parataxis|inhibition inhibition|nmod|signaling signaling|amod|END_ENTITY	Imatinib blocks spontaneous mechanical activities in the adult mouse small intestine : possible inhibition of c-Kit signaling .
25621158	0	Imatinib	0,8	c-Kit	45,50	Imatinib	c-Kit	MESH:C097613	3815	Chemical	Gene	START_ENTITY|dep|inhibition inhibition|amod|END_ENTITY	Imatinib in pulmonary_arterial_hypertension : c-Kit inhibition .
15659505	0	Imatinib	0,8	c-kit	92,97	Imatinib	c-kit	MESH:C097613	3815	Chemical	Gene	mesylate|amod|START_ENTITY glands|nsubj|mesylate glands|xcomp|expressing expressing|dobj|END_ENTITY	Imatinib mesylate in patients with adenoid_cystic_cancers of the salivary glands expressing c-kit : a Princess Margaret Hospital phase II consortium study .
15812822	0	Imatinib	0,8	c-kit	73,78	Imatinib	c-kit	MESH:C097613	3815	Chemical	Gene	mesylate|compound|START_ENTITY lacks|nsubj|mesylate lacks|nmod|small_cell_lung_carcinoma small_cell_lung_carcinoma|acl|expressing expressing|dobj|protein protein|amod|END_ENTITY	Imatinib mesylate lacks activity in small_cell_lung_carcinoma expressing c-kit protein : a phase II clinical trial .
18843975	0	Imatinib	1,9	c-kit	18,23	Imatinib	c-kit	MESH:C097613	3815	Chemical	Gene	induces|nsubj|START_ENTITY induces|ccomp|apoptosis apoptosis|nsubj|cells cells|amod|END_ENTITY	-LSB- Imatinib induces c-kit positive myeloma cells apoptosis -RSB- .
21561667	0	Imatinib	0,8	c-kit	82,87	Imatinib	c-kit	MESH:C097613	403811(Tax:9615)	Chemical	Gene	elicited|nsubj|START_ENTITY elicited|nmod|mast_cell_tumor mast_cell_tumor|acl|carrying carrying|dobj|mutation mutation|amod|END_ENTITY	Imatinib elicited a favorable response in a dog with a mast_cell_tumor carrying a c-kit c. 1523A > T mutation via suppression of constitutive KIT activation .
23972517	0	Imatinib_Mesylate	44,61	JNK	70,73	Imatinib Mesylate	JNK	MESH:C097613	5599	Chemical	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	Wnt5a enhances the response of CML cells to Imatinib_Mesylate through JNK activation and y-catenin inhibition .
19568828	0	Imatinib_mesylate	0,17	Akt	126,129	Imatinib mesylate	Akt	MESH:C097613	24185(Tax:10116)	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|nmod|END_ENTITY	Imatinib_mesylate inhibited rat adjuvant arthritis and PDGF-dependent growth of synovial fibroblast via interference with the Akt signaling pathway .
18981115	0	Imatinib_mesylate	0,17	CD25	32,36	Imatinib mesylate	CD25	MESH:C097613	16184(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	Imatinib_mesylate inhibits CD4 + CD25 + regulatory T cell activity and enhances active immunotherapy against BCR-ABL - _ tumors .
18981115	0	Imatinib_mesylate	0,17	CD4	27,30	Imatinib mesylate	CD4	MESH:C097613	12504(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	Imatinib_mesylate inhibits CD4 + CD25 + regulatory T cell activity and enhances active immunotherapy against BCR-ABL - _ tumors .
15251980	0	Imatinib_mesylate	0,17	breast_cancer_resistance_protein	50,82	Imatinib mesylate	breast cancer resistance protein	MESH:C097613	9429	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Imatinib_mesylate -LRB- STI571 -RRB- is a substrate for the breast_cancer_resistance_protein -LRB- BCRP -RRB- / ABCG2 drug pump .
12496355	0	Imatinib_mesylate	0,17	vascular_endothelial_growth_factor	53,87	Imatinib mesylate	vascular endothelial growth factor	MESH:C097613	7422	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|secretion secretion|compound|END_ENTITY	Imatinib_mesylate -LRB- STI-571 -RRB- reduces Bcr-Abl-mediated vascular_endothelial_growth_factor secretion in chronic_myelogenous_leukemia .
18080902	0	Imidacloprid	0,12	glial_fibrillary_acidic_protein	74,105	Imidacloprid	glial fibrillary acidic protein	MESH:C082359	24387(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Imidacloprid induces neurobehavioral_deficits and increases expression of glial_fibrillary_acidic_protein in the motor cortex and hippocampus in offspring rats following in utero exposure .
10535386	0	Imidapril	0,9	angiotensin-converting_enzyme	14,43	Imidapril	angiotensin-converting enzyme	MESH:C065166	24310(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Imidapril , an angiotensin-converting_enzyme inhibitor , improves insulin sensitivity by enhancing signal transduction via insulin receptor substrate proteins and improving vascular resistance in the Zucker fatty rat .
9274926	0	Imidapril	0,9	transforming_growth_factor-beta1	29,61	Imidapril	transforming growth factor-beta1	MESH:C065166	59086(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Imidapril inhibits increased transforming_growth_factor-beta1 expression in remnant kidney model .
20356739	0	Imidazoacridin-6-ones	0,21	NQO2	72,76	Imidazoacridin-6-ones	NQO2	null	4835	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Imidazoacridin-6-ones as novel inhibitors of the quinone oxidoreductase NQO2 .
16275025	0	Imidazole	0,9	nNOS	66,70	Imidazole	nNOS	MESH:C029899	4842	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Imidazole derivatives as antioxidants and selective inhibitors of nNOS .
2995119	0	Imidazolyl	0,10	angiotensin_converting_enzyme	49,78	Imidazolyl	angiotensin converting enzyme	null	1636	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|inhibitors inhibitors|compound|END_ENTITY	Imidazolyl derivatives of enalapril as potential angiotensin_converting_enzyme inhibitors .
21420860	0	Imidazopyridine	0,15	CB2	16,19	Imidazopyridine	CB2	CHEBI:46908	57302(Tax:10116)	Chemical	Gene	agonists|amod|START_ENTITY agonists|compound|END_ENTITY	Imidazopyridine CB2 agonists : optimization of CB2/CB1 selectivity and implications for in vivo analgesic efficacy .
19589677	0	Imidazopyridine	0,15	Polo-like_kinase	52,68	Imidazopyridine	Polo-like kinase	CHEBI:46908	25515(Tax:10116)	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Imidazopyridine derivatives as potent and selective Polo-like_kinase -LRB- PLK -RRB- inhibitors .
26381330	0	Imidazotriazines	0,16	Spleen_Tyrosine_Kinase	18,40	Imidazotriazines	Spleen Tyrosine Kinase	CHEBI:46906	6850	Chemical	Gene	START_ENTITY|dep|Inhibitors Inhibitors|compound|END_ENTITY	Imidazotriazines : Spleen_Tyrosine_Kinase -LRB- Syk -RRB- Inhibitors Identified by Free-Energy Perturbation -LRB- FEP -RRB- .
25147615	0	Imigliptin	13,23	DPP-4	43,48	Imigliptin	DPP-4	null	1803	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|compound|END_ENTITY	Discovery of Imigliptin , a Novel Selective DPP-4 Inhibitor for the Treatment of Type 2 Diabetes .
18006322	0	Imine	0,5	CB2	46,49	Imine	CB2	CHEBI:24783	57302(Tax:10116)	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Imine derivatives as new potent and selective CB2 cannabinoid receptor agonists with an analgesic action .
16759106	0	Imino-tetrahydro-benzothiazole	0,30	p53	46,49	Imino-tetrahydro-benzothiazole	p53	null	7157	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|inhibitors inhibitors|compound|END_ENTITY	Imino-tetrahydro-benzothiazole derivatives as p53 inhibitors : discovery of a highly potent in vivo inhibitor and its action mechanism .
25156823	0	Imipramine	0,10	Brain-derived_Neurotrophic_Factor	70,103	Imipramine	Brain-derived Neurotrophic Factor	MESH:D007099	24225(Tax:10116)	Chemical	Gene	Emotion|compound|START_ENTITY Emotion|nmod|END_ENTITY	Imipramine Ameliorates Pain-related Negative Emotion via Induction of Brain-derived_Neurotrophic_Factor .
22026997	0	Imipramine	0,10	PEP-1-Catalase	46,60	Imipramine	PEP-1-Catalase	MESH:D007099	847	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|effect effect|nmod|END_ENTITY	Imipramine enhances neuroprotective effect of PEP-1-Catalase against ischemic_neuronal_damage .
23076128	0	Imipramine	0,10	brain-derived_neurotrophic_factor	19,52	Imipramine	brain-derived neurotrophic factor	MESH:D007099	24225(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Imipramine induces brain-derived_neurotrophic_factor mRNA expression in cultured astrocytes .
21354245	0	Imipramine	0,10	glial_cell_line-derived_neurotrophic_factor	21,64	Imipramine	glial cell line-derived neurotrophic factor	MESH:D007099	14573(Tax:10090)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Imipramine activates glial_cell_line-derived_neurotrophic_factor via early growth response gene 1 in astrocytes .
20043526	0	Imipramine	0,10	prolactin	32,41	Imipramine	prolactin	MESH:D007099	5617	Chemical	Gene	elevation|compound|START_ENTITY elevation|nmod|levels levels|compound|END_ENTITY	Imipramine induced elevation of prolactin levels in patients with HIV/AIDS improved their immune status .
21953855	0	Imiquimod	28,37	Toll-like_receptor-7	0,20	Imiquimod	Toll-like receptor-7	MESH:C056493	170743(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY ligand|ccomp|induces ligand|nsubj|END_ENTITY	Toll-like_receptor-7 ligand Imiquimod induces type I interferon and antimicrobial peptides to ameliorate dextran sodium_sulfate-induced acute_colitis .
27043440	0	Imperatorin	0,11	BAA-1717	87,95	Imperatorin	BAA-1717	MESH:C031534	7852842(Tax:592021)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Imperatorin inhibits the expression of alpha-hemolysin in Staphylococcus_aureus strain BAA-1717 -LRB- USA300 -RRB- .
6449204	0	Impromidine	0,11	histamine_methyltransferase	35,62	Impromidine	histamine methyltransferase	MESH:D017446	3176	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Impromidine , a potent inhibitor of histamine_methyltransferase -LRB- HMT -RRB- and diamine_oxidase -LRB- DAO -RRB- .
15210067	0	Imrecoxib	0,9	cyclooxygenase_2	33,49	Imrecoxib	cyclooxygenase 2	MESH:C488833	29527(Tax:10116)	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Imrecoxib : a novel and selective cyclooxygenase_2 inhibitor with anti-inflammatory effect .
26809306	0	Inappropriate	22,35	Antidiuretic_Hormone	49,69	Inappropriate	Antidiuretic Hormone	null	551	Chemical	Gene	Secretion|compound|START_ENTITY Secretion|nmod|END_ENTITY	-LSB- Onset of Syndrome of Inappropriate Secretion of Antidiuretic_Hormone in a Gastric_Cancer Patient on SOX Treatment -RSB- .
17653089	0	Inappropriate	0,13	androgen_receptor	28,45	Inappropriate	androgen receptor	null	367	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Inappropriate activation of androgen_receptor by relaxin via beta-catenin pathway .
1052263	0	Inappropriate	0,13	insulin	51,58	Inappropriate	insulin	null	3630	Chemical	Gene	levels|amod|START_ENTITY levels|nmod|END_ENTITY	Inappropriate counter-regulatory hormone levels in insulin treated diabetes .
1052833	0	Inappropriate	0,13	insulin	51,58	Inappropriate	insulin	null	3630	Chemical	Gene	levels|amod|START_ENTITY levels|nmod|END_ENTITY	Inappropriate counter-regulatory hormone levels in insulin treated diabetes .
7239450	0	Inappropriate	0,13	mucin	14,19	Inappropriate	mucin	null	100508689	Chemical	Gene	production|amod|START_ENTITY production|compound|END_ENTITY	Inappropriate mucin production in gall_bladder_metaplasia and neoplasia -- an immunohistological study .
22331558	0	Inauhzin	17,25	SIRT1	35,40	Inauhzin	SIRT1	MESH:C573921	23411	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53 .
16019130	0	Incadronate	0,11	aminopeptidase_N	21,37	Incadronate	aminopeptidase N	MESH:C071542	290	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Incadronate inhibits aminopeptidase_N expression in prostatic PC-3 cells .
1656721	0	Indapamide	0,10	bradykinin	97,107	Indapamide	bradykinin	MESH:D007190	3827	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|nmod|END_ENTITY	Indapamide potentiates the endothelium-dependent production of cyclic_guanosine_monophosphate by bradykinin in the canine femoral artery .
20971001	0	Indazole	0,8	bradykinin_B1_receptor	30,52	Indazole	bradykinin B1 receptor	CHEBI:36669	623	Chemical	Gene	START_ENTITY|nmod|antagonists antagonists|amod|END_ENTITY	Indazole derivatives as novel bradykinin_B1_receptor antagonists .
24955776	0	Indazole	0,8	monoamine_oxidase_B	62,81	Indazole	monoamine oxidase B	CHEBI:36669	4129	Chemical	Gene	START_ENTITY|dep|inhibitors inhibitors|compound|END_ENTITY	Indazole - and indole-5-carboxamides : selective and reversible monoamine_oxidase_B inhibitors with subnanomolar potency .
12712244	0	Indinavir	0,9	GLUT4	46,51	Indinavir	GLUT4	MESH:D019469	20528(Tax:10090)	Chemical	Gene	uncovers|nsubj|START_ENTITY uncovers|dobj|contributions contributions|nmod|END_ENTITY	Indinavir uncovers different contributions of GLUT4 and GLUT1 towards glucose uptake in muscle and fat cells and tissues .
11919487	0	Indinavir	0,9	Glut4	51,56	Indinavir	Glut4	MESH:D019469	25139(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Indinavir inhibits the glucose transporter isoform Glut4 at physiologic concentrations .
22721997	0	Indirubin	0,9	EGFR	61,65	Indirubin	EGFR	MESH:C027185	1956	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	Indirubin , an acting component of indigo naturalis , inhibits EGFR activation and EGF-induced CDC25B gene expression in epidermal keratinocytes .
20153646	0	Indirubin	0,9	FLT3	32,36	Indirubin	FLT3	MESH:C027185	2322	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	Indirubin derivatives as potent FLT3 inhibitors with anti-proliferative activity of acute_myeloid_leukemic cells .
26987505	0	Indirubin	0,9	pregnane_X_receptor	93,112	Indirubin	pregnane X receptor	MESH:C027185	8856	Chemical	Gene	activates|nsubj|START_ENTITY activates|nmod|END_ENTITY	Indirubin , a component of Ban-Lan-Gen , activates CYP3A4 gene transcription through the human pregnane_X_receptor .
2024472	0	Indiscriminate	0,14	B19	33,36	Indiscriminate	B19	null	30811	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Indiscriminate activity from the B19 parvovirus p6 promoter in nonpermissive cells .
17336065	0	Indole	0,6	5-lipoxygenase	43,57	Indole	5-lipoxygenase	MESH:C030374	25290(Tax:10116)	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|inhibitors inhibitors|nmod|END_ENTITY	Indole derivatives as potent inhibitors of 5-lipoxygenase : design , synthesis , biological evaluation , and molecular modeling .
26214135	0	Indole	42,48	Matrix_Metalloproteinase-13	63,90	Indole	Matrix Metalloproteinase-13	MESH:C030374	4322	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|nmod|END_ENTITY	Correction to Fragment-Based Discovery of Indole Inhibitors of Matrix_Metalloproteinase-13 .
14552795	0	Indole-2-carboxamides	0,21	NR2B	31,35	Indole-2-carboxamides	NR2B	null	2904	Chemical	Gene	START_ENTITY|dobj|antagonists antagonists|nummod|END_ENTITY	Indole-2-carboxamides as novel NR2B selective NMDA receptor antagonists .
16213709	0	Indole-2-carboxamidines	0,23	NR2B	33,37	Indole-2-carboxamidines	NR2B	null	14812(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|antagonists antagonists|nummod|END_ENTITY	Indole-2-carboxamidines as novel NR2B selective NMDA receptor antagonists .
23580227	0	Indole-3-Carbinol	41,58	TRAIL	78,83	Indole-3-Carbinol	TRAIL	MESH:C016517	8743	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	The synergistic apoptotic interaction of Indole-3-Carbinol and Genistein with TRAIL on endometrial_cancer cells .
16660936	0	Indole-3-acetic_Acid	40,60	Peroxidase	71,81	Indole-3-acetic Acid	Peroxidase	MESH:C030737	543959(Tax:4081)	Chemical	Gene	Oxidation|nmod|START_ENTITY Oxidation|nmod|END_ENTITY	Hydrogen_Peroxide-mediated Oxidation of Indole-3-acetic_Acid by Tomato Peroxidase and Molecular Oxygen .
16152627	0	Indole-3-carbinol	0,17	ATM	32,35	Indole-3-carbinol	ATM	MESH:C016517	472	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Indole-3-carbinol activates the ATM signaling pathway independent of DNA damage to stabilize p53 and induce G1 arrest of human mammary epithelial cells .
11489435	0	Indole-3-carbinol	0,17	CYP1A1	55,61	Indole-3-carbinol	CYP1A1	MESH:C016517	100135512(Tax:10141)	Chemical	Gene	modulation|amod|START_ENTITY monooxygenases|nsubj|modulation monooxygenases|dobj|END_ENTITY	Indole-3-carbinol modulation of hepatic monooxygenases CYP1A1 , CYP1A2 and FMO1 in guinea_pig , mouse and rabbit .
23330137	0	Indole-3-carbinol	0,17	CYP1A1	31,37	Indole-3-carbinol	CYP1A1	MESH:C016517	24296(Tax:10116)	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Indole-3-carbinol induction of CYP1A1 , CYP1A2 , and CYP3A1 activity and gene expression in rat liver under conditions of different fat content in the diet .
25795137	0	Indole-3-carbinol	0,17	Nrf2	120,124	Indole-3-carbinol	Nrf2	MESH:C016517	4780	Chemical	Gene	START_ENTITY|advcl|blocking blocking|dobj|END_ENTITY	Indole-3-carbinol as inhibitors of glucocorticoid-induced apoptosis in osteoblastic cells through blocking ROS-mediated Nrf2 pathway .
22986685	0	Indole-3-carbinol	0,17	SIRT1	35,40	Indole-3-carbinol	SIRT1	MESH:C016517	93759(Tax:10090)	Chemical	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Indole-3-carbinol directly targets SIRT1 to inhibit adipocyte differentiation .
15958518	0	Indole-3-carbinol	0,17	androgen_receptor	32,49	Indole-3-carbinol	androgen receptor	MESH:C016517	367	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|expression expression|compound|END_ENTITY	Indole-3-carbinol inhibition of androgen_receptor expression and downregulation of androgen responsiveness in human prostate_cancer cells .
9461564	0	Indole-3-carbinol	0,17	cyclin-dependent_kinase-6	45,70	Indole-3-carbinol	cyclin-dependent kinase-6	MESH:C016517	1021	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Indole-3-carbinol inhibits the expression of cyclin-dependent_kinase-6 and induces a G1 cell cycle arrest of human breast_cancer cells independent of estrogen_receptor signaling .
16806864	0	Indole-3-carbinol	0,17	cytochrome_P450_1A1	35,54	Indole-3-carbinol	cytochrome P450 1A1	MESH:C016517	24296(Tax:10116)	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|END_ENTITY	Indole-3-carbinol alters placental cytochrome_P450_1A1 and P-glycoprotein levels in rats : a potential role in intensifying fetal intrauterine growth-retardation produced by tobacco smoke .
11110848	0	Indole-3-carbinol	0,17	estrogen_receptor-alpha	45,68	Indole-3-carbinol	estrogen receptor-alpha	MESH:C016517	2099	Chemical	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	Indole-3-carbinol is a negative regulator of estrogen_receptor-alpha signaling in human tumor cells .
16152627	0	Indole-3-carbinol	0,17	p53	93,96	Indole-3-carbinol	p53	MESH:C016517	7157	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|ATM ATM|acl|signaling signaling|xcomp|stabilize stabilize|dobj|END_ENTITY	Indole-3-carbinol activates the ATM signaling pathway independent of DNA damage to stabilize p53 and induce G1 arrest of human mammary epithelial cells .
16970927	0	Indole-3-carbinol	0,17	p53	127,130	Indole-3-carbinol	p53	MESH:C016517	7157	Chemical	Gene	mediated|nsubj|START_ENTITY mediated|ccomp|requires requires|dobj|production production|nmod|protein protein|compound|END_ENTITY	Indole-3-carbinol mediated cell cycle arrest of LNCaP human prostate_cancer cells requires the induced production of activated p53 tumor suppressor protein .
20060030	0	Indole-3-carbinol	0,17	p53	44,47	Indole-3-carbinol	p53	MESH:C016517	7157	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Indole-3-carbinol induces apoptosis through p53 and activation of caspase-8 pathway in lung_cancer A549 cells .
25113875	0	Indole-3-ethylsulfamoylphenylacrylamides	0,40	histone_deacetylase	49,68	Indole-3-ethylsulfamoylphenylacrylamides	histone deacetylase	null	9734	Chemical	Gene	START_ENTITY|dep|inhibitors inhibitors|compound|END_ENTITY	Indole-3-ethylsulfamoylphenylacrylamides : potent histone_deacetylase inhibitors with anti-inflammatory activity .
16380256	0	Indole-glucosides	0,17	sodium_glucose_co-transporter_2	27,58	Indole-glucosides	sodium glucose co-transporter 2	null	64522(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Indole-glucosides as novel sodium_glucose_co-transporter_2 -LRB- SGLT2 -RRB- inhibitors .
15063631	0	Indoleamine	0,11	IDO	29,32	Indoleamine	IDO	CHEBI:28626	3620	Chemical	Gene	supports|advmod|START_ENTITY supports|nsubj|expression expression|appos|END_ENTITY	Indoleamine 2,3-dioxygenase -LRB- IDO -RRB- expression in invasive extravillous trophoblast supports role of the enzyme for materno-fetal tolerance .
22803643	0	Indoleamine	0,11	IDO	29,32	Indoleamine	IDO	CHEBI:28626	3620	Chemical	Gene	2,3-dioxygenase|amod|START_ENTITY 2,3-dioxygenase|appos|END_ENTITY	Indoleamine 2,3-dioxygenase -LRB- IDO -RRB- induced by Leishmania_infection of human dendritic cells .
23926466	0	Indoleamine	0,11	IDO	29,32	Indoleamine	IDO	CHEBI:28626	15930(Tax:10090)	Chemical	Gene	2,3-dioxygenase|amod|START_ENTITY 2,3-dioxygenase|appos|END_ENTITY	Indoleamine 2,3-dioxygenase -LRB- IDO -RRB- is expressed at feto-placental unit throughout mouse gestation : An immunohistochemical study .
25292102	0	Indoleamine	13,24	IDO	42,45	Indoleamine	IDO	CHEBI:28626	3620	Chemical	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of Indoleamine 2,3-dioxygenase -LRB- IDO -RRB- Enzymatic Activity Contributes to Interferon-Gamma Induced Apoptosis and Death_Receptor_5 Expression in Human Non-small_Cell_Lung_Cancer Cells .
25042109	0	Indolyldiketopiperazines	13,37	NBS	43,46	Indolyldiketopiperazines	NBS	null	4683	Chemical	Gene	Synthesis|nmod|START_ENTITY Synthesis|nmod|END_ENTITY	Synthesis of Indolyldiketopiperazines with NBS .
10486359	0	Indomethacin	0,12	CD18	36,40	Indomethacin	CD18	MESH:D007213	16414(Tax:10090)	Chemical	Gene	induced|nsubj|START_ENTITY induced|nmod|END_ENTITY	Indomethacin induced gastropathy in CD18 , intercellular_adhesion_molecule_1 , or P-selectin deficient mice .
26927686	0	Indomethacin	0,12	COX-2	147,152	Indomethacin	COX-2	MESH:D007213	4513	Chemical	Gene	based|nsubj|START_ENTITY based|nmod|line line|acl|related related|nmod|inhibition inhibition|compound|END_ENTITY	Indomethacin based new triazolothiadiazine derivatives : Synthesis , evaluation of their anticancer effects on T98 human glioma cell line related to COX-2 inhibition and docking studies .
8393395	0	Indomethacin	0,12	CRH	108,111	Indomethacin	CRH	MESH:D007213	1392	Chemical	Gene	alter|nsubj|START_ENTITY alter|nmod|corticotropin-releasing_hormone corticotropin-releasing_hormone|appos|END_ENTITY	Indomethacin and meclofenamate do not alter ACTH and cortisol responses to corticotropin-releasing_hormone -LRB- CRH -RRB- in normal subjects .
25212253	0	Indomethacin	0,12	LAMP-2	24,30	Indomethacin	LAMP-2	MESH:D007213	24944(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Indomethacin suppresses LAMP-2 expression and induces lipophagy and lipoapoptosis in rat enterocytes via the ER stress pathway .
9258207	0	Indomethacin	0,12	atrial_natriuretic_factor	45,70	Indomethacin	atrial natriuretic factor	MESH:D007213	608289(Tax:9615)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|actions actions|nmod|END_ENTITY	Indomethacin attenuates the renal actions of atrial_natriuretic_factor in dogs with chronic_heart_failure .
11756231	0	Indomethacin	0,12	beta-catenin	48,60	Indomethacin	beta-catenin	MESH:D007213	1499	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|genes genes|amod|END_ENTITY	Indomethacin induces differential expression of beta-catenin , gamma-catenin and T-cell_factor target genes in human colorectal_cancer cells .
2500119	0	Indomethacin	0,12	c-fos	32,37	Indomethacin	c-fos	MESH:D007213	2353	Chemical	Gene	shifts|nsubj|START_ENTITY shifts|dobj|peak peak|nmod|expression expression|amod|END_ENTITY	Indomethacin shifts the peak of c-fos , egr-1 , and c-myc gene expression in confluent fibroblasts induced by phorbol_myristate_acetate .
2500119	0	Indomethacin	0,12	egr-1	39,44	Indomethacin	egr-1	MESH:D007213	1958	Chemical	Gene	shifts|nsubj|START_ENTITY shifts|dobj|peak peak|nmod|expression expression|amod|END_ENTITY	Indomethacin shifts the peak of c-fos , egr-1 , and c-myc gene expression in confluent fibroblasts induced by phorbol_myristate_acetate .
25110317	0	Indomethacin	0,12	endothelial_nitric_oxide_synthase	36,69	Indomethacin	endothelial nitric oxide synthase	MESH:D007213	24600(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	Indomethacin inhibits activation of endothelial_nitric_oxide_synthase in the rat kidney : Possible role of this effect in the pathogenesis of indomethacin-induced renal_damage .
8549878	0	Indomethacin	0,12	epidermal_growth_factor	29,52	Indomethacin	epidermal growth factor	MESH:D007213	1950	Chemical	Gene	interferes|nsubj|START_ENTITY interferes|nmod|binding binding|nmod:npmod|END_ENTITY	Indomethacin interferes with epidermal_growth_factor binding and proliferative response of gastric KATO III cells .
8458923	0	Indomethacin	0,12	gonadotrophin-releasing_hormone	91,122	Indomethacin	gonadotrophin-releasing hormone	MESH:D007213	2796	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Indomethacin in vivo inhibits the enhancement of the progesterone secretion in response to gonadotrophin-releasing_hormone by human corpus luteum .
2240004	0	Indomethacin	0,12	growth_hormone	30,44	Indomethacin	growth hormone	MESH:D007213	2688	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|compound|END_ENTITY	Indomethacin increases plasma growth_hormone levels in man .
3923840	0	Indomethacin	0,12	insulin	47,54	Indomethacin	insulin	MESH:D007213	483665(Tax:9615)	Chemical	Gene	modulate|nsubj|START_ENTITY modulate|dobj|effect effect|nmod|END_ENTITY	Indomethacin and salicylate modulate effect of insulin on glucose kinetics in dogs .
6989847	0	Indomethacin	0,12	insulin	71,78	Indomethacin	insulin	MESH:D007213	3630	Chemical	Gene	prevent|nsubj|START_ENTITY prevent|dobj|fall fall|nmod|END_ENTITY	Indomethacin and aspirin prevent the starvation-induced fall in plasma insulin .
9700679	0	Indomethacin	0,12	interleukin-1_beta	95,113	Indomethacin	interleukin-1 beta	MESH:D007213	24494(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|nmod|END_ENTITY	Indomethacin attenuates oxytocin and hypothalamic-pituitary-adrenal_axis responses to systemic interleukin-1_beta .
6428199	0	Indomethacin	0,12	prolactin	24,33	Indomethacin	prolactin	MESH:D007213	5617	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|release release|compound|END_ENTITY	Indomethacin suppresses prolactin release in men .
23582181	0	Indomethacin	0,12	prostaglandin_D2	46,62	Indomethacin	prostaglandin D2	MESH:D007213	5730	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Indomethacin inhibits eosinophil migration to prostaglandin_D2 : therapeutic potential of CRTH2 desensitization for eosinophilic_pustular_folliculitis .
7686103	0	Indomethacin	0,12	substance_P	21,32	Indomethacin	substance P	MESH:D007213	6863	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|levels levels|compound|END_ENTITY	Indomethacin reduces substance_P levels in human ocular_aqueous_humor .
25376195	0	Indoxyl_Sulfate	0,15	IL-6	24,28	Indoxyl Sulfate	IL-6	MESH:D007200	3569	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Indoxyl_Sulfate Induces IL-6 Expression in Vascular Endothelial and Smooth Muscle Cells through OAT3-Mediated Uptake and Activation of AhR/NF-kB Pathway .
25556305	0	Indoxyl_Sulfate	0,15	p65	70,73	Indoxyl Sulfate	p65	MESH:D007200	5970	Chemical	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	Indoxyl_Sulfate Upregulates Prorenin Expression via Nuclear Factor-kB p65 , Signal_Transducer_and_Activator_of_Transcription_3 , and Reactive Oxygen Species in Proximal Tubular Cells .
20937831	0	Indoxyl_sulfate	0,15	E-selectin	84,94	Indoxyl sulfate	E-selectin	MESH:D007200	6401	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|up-regulation up-regulation|nmod|END_ENTITY	Indoxyl_sulfate induces leukocyte-endothelial interactions through up-regulation of E-selectin .
26659566	0	Indoxyl_sulfate	0,15	E-selectin	39,49	Indoxyl sulfate	E-selectin	MESH:D007200	6401	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Indoxyl_sulfate enhances IL-1b-induced E-selectin expression in endothelial cells in acute_kidney_injury by the ROS/MAPKs/NFkB / AP-1 pathway .
23874392	0	Indoxyl_sulfate	0,15	GATA3	76,81	Indoxyl sulfate	GATA3	MESH:D007200	85471(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|up-regulation up-regulation|nmod|END_ENTITY	Indoxyl_sulfate down-regulates SLCO4C1 transporter through up-regulation of GATA3 .
21389697	0	Indoxyl_sulfate	0,15	Klotho	50,56	Indoxyl sulfate	Klotho	MESH:D007200	83504(Tax:10116)	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|nmod|END_ENTITY	Indoxyl_sulfate downregulates renal expression of Klotho through production of ROS and activation of nuclear factor - B. BACKGROUND/AIM : Klotho , an anti-aging gene , is expressed in the kidneys , and its renal expression is decreased_in_chronic_kidney_disease -LRB- CKD -RRB- .
23496811	0	Indoxyl_sulfate	0,15	NF-kB	94,99	Indoxyl sulfate	NF-kB	MESH:D007200	309165(Tax:10116)	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|nmod|activation activation|nmod|END_ENTITY	Indoxyl_sulfate , a uremic toxin , downregulates renal expression of Nrf2 through activation of NF-kB .
23496811	0	Indoxyl_sulfate	0,15	Nrf2	67,71	Indoxyl sulfate	Nrf2	MESH:D007200	83619(Tax:10116)	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|nmod|END_ENTITY	Indoxyl_sulfate , a uremic toxin , downregulates renal expression of Nrf2 through activation of NF-kB .
26068716	0	Indoxyl_sulfate	0,15	aryl_hydrocarbon_receptor	63,88	Indoxyl sulfate	aryl hydrocarbon receptor	MESH:D007200	196	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|nmod|END_ENTITY	Indoxyl_sulfate suppresses hepatic fetuin-A expression via the aryl_hydrocarbon_receptor in HepG2 cells .
26068716	0	Indoxyl_sulfate	0,15	fetuin-A	35,43	Indoxyl sulfate	fetuin-A	MESH:D007200	197	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Indoxyl_sulfate suppresses hepatic fetuin-A expression via the aryl_hydrocarbon_receptor in HepG2 cells .
20818133	0	Indoxyl_sulfate	0,15	monocyte_chemoattractant_protein-1	27,61	Indoxyl sulfate	monocyte chemoattractant protein-1	MESH:D007200	6347	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Indoxyl_sulfate stimulates monocyte_chemoattractant_protein-1 expression in human umbilical vein endothelial cells by inducing oxidative stress through activation of the NADPH oxidase-nuclear factor-kB pathway .
22555846	0	Indoxyl_sulfate	0,15	p53	85,88	Indoxyl sulfate	p53	MESH:D007200	301300(Tax:10116)	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|xcomp|vascular vascular|dobj|senescence senescence|nmod|upregulation upregulation|nmod|END_ENTITY	Indoxyl_sulfate promotes vascular smooth muscle cell senescence with upregulation of p53 , p21 , and prelamin_A through oxidative stress .
12176808	0	Infliximab	0,10	cyclosporin_A	41,54	Infliximab	cyclosporin A	null	1161	Chemical	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	Infliximab treatment in combination with cyclosporin_A in patients with severe refractory_rheumatoid_arthritis .
11026448	0	Innate	0,6	interleukin-10	21,35	Innate	interleukin-10	null	3586	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Innate production of interleukin-10 and tumor_necrosis_factor affects the risk of multiple_sclerosis .
26121039	0	Inosine_Monophosphate	75,96	NUDT16	46,52	Inosine Monophosphate	NUDT16	MESH:D007291	131870	Chemical	Gene	Basis|nmod|START_ENTITY Basis|nmod|END_ENTITY	Structural Basis for the Specificity of Human NUDT16 and Its Regulation by Inosine_Monophosphate .
25968438	0	Inosine_triphosphate	0,20	ITPA	143,147	Inosine triphosphate	ITPA	MESH:D007293	3704	Chemical	Gene	activity|amod|START_ENTITY activity|dep|predictor predictor|nmod|anemia anemia|nmod|patients patients|nmod|genotype genotype|compound|END_ENTITY	Inosine_triphosphate pyrophosphohydrolase activity : more accurate predictor for ribavirin-induced anemia in hepatitis_C infected patients than ITPA genotype .
27004129	0	Inositol	0,8	AtINT2	22,28	Inositol	AtINT2	MESH:D007294	839902(Tax:3702)	Chemical	Gene	transporters|nsubj|START_ENTITY transporters|ccomp|regulate regulate|nsubj|END_ENTITY	Inositol transporters AtINT2 and AtINT4 regulate arsenic accumulation in Arabidopsis seeds .
23805271	0	Inositol	21,29	INPP5B	44,50	Inositol	INPP5B	MESH:D007294	3633	Chemical	Gene	Role|nmod|START_ENTITY END_ENTITY|nsubj|Role	Compensatory Role of Inositol 5-Phosphatase INPP5B to OCRL in Primary Cilia Formation in Oculocerebrorenal_Syndrome_of_Lowe .
20810657	0	Inositol	155,163	SHIP1	180,185	Inositol	SHIP1	MESH:D007294	3635	Chemical	Gene	activity|nmod|START_ENTITY activity|appos|END_ENTITY	A key role for the phosphorylation of Ser440 by the cyclic_AMP-dependent protein kinase in regulating the activity of the Src homology 2 domain-containing Inositol 5 ' - phosphatase -LRB- SHIP1 -RRB- .
1770982	0	Inositol	0,8	bradykinin	52,62	Inositol	bradykinin	MESH:D007294	3827	Chemical	Gene	START_ENTITY|nmod|stimulation stimulation|compound|END_ENTITY	Inositol phosphates and intracellular calcium after bradykinin stimulation in fibroblasts from young , normal aged and Alzheimer donors .
1317169	0	Inositol	0,8	filamin	88,95	Inositol	filamin	MESH:D007294	2318	Chemical	Gene	suppression|amod|START_ENTITY suppression|nmod|END_ENTITY	Inositol phospholipid-induced suppression of F-actin-gelating activity of smooth muscle filamin .
2543408	0	Inositol	0,8	vasopressin	29,40	Inositol	vasopressin	MESH:D007294	551	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|nmod|END_ENTITY	Inositol lipid metabolism in vasopressin stimulated hepatocytes from rats infused with tumor necrosis factor .
10403548	0	Inositol_hexaphosphate	0,22	ornithine_decarboxylase	76,99	Inositol hexaphosphate	ornithine decarboxylase	MESH:D010833	18263(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|amod|END_ENTITY	Inositol_hexaphosphate reduces 12-O-tetradecanoylphorbol-13-acetate-induced ornithine_decarboxylase independent of protein kinase C isoform expression in keratinocytes .
14755253	0	Inositol_pentakisphosphate	0,26	Akt	65,68	Inositol pentakisphosphate	Akt	MESH:C013571	207	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|pathway pathway|compound|END_ENTITY	Inositol_pentakisphosphate promotes apoptosis through the PI_3-K / Akt pathway .
14755253	0	Inositol_pentakisphosphate	0,26	PI_3-K	58,64	Inositol pentakisphosphate	PI 3-K	MESH:C013571	5293	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|pathway pathway|compound|END_ENTITY	Inositol_pentakisphosphate promotes apoptosis through the PI_3-K / Akt pathway .
3223917	0	Inositol_phosphate	0,18	thrombin	108,116	Inositol phosphate	thrombin	CHEBI:24846	2147	Chemical	Gene	production|amod|START_ENTITY stimulated|nsubj|production stimulated|nmod|END_ENTITY	Inositol_phosphate production and Ca2 + mobilization in human umbilical-vein endothelial cells stimulated by thrombin and histamine .
8608601	0	Inositol_trisphosphate	0,22	Ca2	65,68	Inositol trisphosphate	Ca2	null	760	Chemical	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	Inositol_trisphosphate and cyclic_ADP-ribose-mediated release of Ca2 + from single isolated pancreatic zymogen granules .
20432191	0	Intedanib	0,9	VEGFR	40,45	Intedanib	VEGFR	null	3791	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Intedanib , a triple kinase inhibitor of VEGFR , FGFR and PDGFR for the treatment of cancer and idiopathic_pulmonary_fibrosis .
1761529	0	Interferon	0,10	tryptophanyl-tRNA_synthetase	19,47	Interferon	tryptophanyl-tRNA synthetase	MESH:D007372	7453	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Interferon induces tryptophanyl-tRNA_synthetase expression in human fibroblasts .
9625761	0	Interferon	0,10	vascular_cell_adhesion_molecule_1	50,83	Interferon	vascular cell adhesion molecule 1	MESH:D007372	7412	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	Interferon enhances tumor_necrosis_factor-induced vascular_cell_adhesion_molecule_1 -LRB- CD106 -RRB- expression in human endothelial cells by an interferon-related factor 1-dependent pathway .
25173752	0	Intestine	66,75	Glucagon-Like_Peptide_2	0,23	Intestine	Glucagon-Like Peptide 2	null	2641	Chemical	Gene	Release|nmod|START_ENTITY Release|compound|END_ENTITY	Glucagon-Like_Peptide_2 Regulates Release of Chylomicron from the Intestine .
9160859	0	Intracrine	0,10	basic_fibroblast_growth_factor	36,66	Intracrine	basic fibroblast growth factor	null	14173(Tax:10090)	Chemical	Gene	effects|compound|START_ENTITY effects|nmod|END_ENTITY	Intracrine and autocrine effects of basic_fibroblast_growth_factor in vascular smooth muscle cells .
25736326	0	Intrauterine	27,39	Myostatin	14,23	Intrauterine	Myostatin	null	2660	Chemical	Gene	Restriction|compound|START_ENTITY END_ENTITY|nmod|Restriction	Expression of Myostatin in Intrauterine Growth Restriction and Preeclampsia Complicated Pregnancies and Alterations to Cytokine Production by First-Trimester Placental Explants Following Myostatin Treatment .
22690802	0	Intrauterine	0,12	insulin	13,20	Intrauterine	insulin	null	3630	Chemical	Gene	START_ENTITY|dobj|resistance resistance|compound|END_ENTITY	Intrauterine insulin resistance in fetuses of overweight mothers .
16839256	0	Iodide	0,6	vascular_endothelial_growth_factor-A	16,52	Iodide	vascular endothelial growth factor-A	CHEBI:16382	7422	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Iodide inhibits vascular_endothelial_growth_factor-A expression in cultured human thyroid follicles : a microarray search for effects of thyrotropin and iodide on angiogenesis factors .
24707288	0	Iodine	0,6	IP-10	24,29	Iodine	IP-10	MESH:D007455	245920(Tax:10116)	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Iodine Intake Increases IP-10 Expression in the Serum and Thyroids of Rats with Experimental Autoimmune_Thyroiditis .
26587031	0	Iodine	73,79	Milk	97,101	Iodine	Milk	MESH:D007455	100532204	Chemical	Gene	Concentration|compound|START_ENTITY Concentration|nmod|END_ENTITY	Heating Process in Pasteurization and not in Sterilization Decreases the Iodine Concentration of Milk .
26802650	0	Iodine	34,40	NDRG2	18,23	Iodine	NDRG2	MESH:D007455	57447	Chemical	Gene	Uptake|compound|START_ENTITY Uptake|compound|END_ENTITY	Overexpression of NDRG2 Increases Iodine Uptake and Inhibits Thyroid_Carcinoma Cell Growth In Situ and In Vivo .
8257866	0	Iodine	0,6	endothelin-1	21,33	Iodine	endothelin-1	MESH:D007455	1906	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Iodine regulation of endothelin-1 gene expression in cultured porcine thyroid cells : possible involvement in autoregulation of the thyroid .
1472632	0	Iodine	0,6	thyroglobulin	22,35	Iodine	thyroglobulin	MESH:D007455	24826(Tax:10116)	Chemical	Gene	content|amod|START_ENTITY content|nmod|END_ENTITY	Iodine content of rat thyroglobulin affects its antigenicity in inducing lymphocytic_thyroiditis in the BB/Wor rat .
20687399	0	Iodine	0,6	thyroglobulin	18,31	Iodine	thyroglobulin	MESH:D007455	21819(Tax:10090)	Chemical	Gene	content|amod|START_ENTITY content|nmod|END_ENTITY	Iodine content of thyroglobulin in Nod.H2h4 mice developing iodine-accelerated autoimmune_thyroiditis .
4018393	0	Iodine	0,6	thyroglobulin	30,43	Iodine	thyroglobulin	MESH:D007455	24826(Tax:10116)	Chemical	Gene	content|amod|START_ENTITY content|nmod|END_ENTITY	Iodine content and density of thyroglobulin investigated by isopycnic centrifugation .
6630417	0	Iodine	0,6	thyroglobulin	24,37	Iodine	thyroglobulin	MESH:D007455	7038	Chemical	Gene	content|amod|START_ENTITY content|nmod|END_ENTITY	Iodine content of serum thyroglobulin in normal individuals and patients with thyroid_tumors .
6449564	0	Iodoacetate	0,11	glyceraldehyde-3-phosphate_dehydrogenase	26,66	Iodoacetate	glyceraldehyde-3-phosphate dehydrogenase	null	2597	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Iodoacetate inhibition of glyceraldehyde-3-phosphate_dehydrogenase as a model of human myophosphorylase_deficiency -LRB- McArdle 's _ disease -RRB- and phosphofructokinase_deficiency -LRB- Tarui 's _ disease -RRB- .
580134	0	Iodoamino_acid	0,14	thyroglobulin	53,66	Iodoamino acid	thyroglobulin	CHEBI:24862	7038	Chemical	Gene	composition|amod|START_ENTITY composition|nmod|END_ENTITY	Iodoamino_acid composition of poorly iodinated human thyroglobulin fractionated by isopycnic centrifugation .
25585347	0	Iopromide	0,9	IFN-y	30,35	Iopromide	IFN-y	MESH:C038192	3458	Chemical	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	Iopromide in combination with IFN-y induces the activation of HMC-1 cells via IL-4 and MCP-1 expression .
35794	0	Iopronic_acid	0,13	cytochrome_P-450	50,66	Iopronic acid	cytochrome P-450	MESH:C006754	4051	Chemical	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	Iopronic_acid interaction with hepatic microsomal cytochrome_P-450 : relationship between chemical structure and binding .
6431500	0	Iothalamate	0,11	lipoxygenase	58,70	Iothalamate	lipoxygenase	MESH:D007483	547836(Tax:3847)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|END_ENTITY	Iothalamate stimulates hydroperoxide formation by soybean lipoxygenase .
9849822	0	Ipamorelin	0,10	growth_hormone	32,46	Ipamorelin	growth hormone	MESH:C114611	81668(Tax:10116)	Chemical	Gene	START_ENTITY|appos|secretagogue secretagogue|compound|END_ENTITY	Ipamorelin , the first selective growth_hormone secretagogue .
22507206	0	Ipragliflozin	13,26	SGLT2	147,152	Ipragliflozin	SGLT2	MESH:C572941	64522(Tax:10116)	Chemical	Gene	Discovery|nmod|START_ENTITY Discovery|dep|inhibitor inhibitor|appos|END_ENTITY	Discovery of Ipragliflozin -LRB- ASP1941 -RRB- : a novel C-glucoside with benzothiophene structure as a potent and selective sodium_glucose co-transporter 2 -LRB- SGLT2 -RRB- inhibitor for the treatment of type_2_diabetes_mellitus .
23563279	0	Ipragliflozin	0,13	SGLT2	56,61	Ipragliflozin	SGLT2	MESH:C572941	6524	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Ipragliflozin and other sodium-glucose_cotransporter-2 -LRB- SGLT2 -RRB- inhibitors in the treatment of type 2 diabetes : preclinical and clinical data .
25701721	0	Ipragliflozin	0,13	SGLT2	18,23	Ipragliflozin	SGLT2	MESH:C572941	64522(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Ipragliflozin , an SGLT2 inhibitor , exhibits a prophylactic effect on hepatic_steatosis and fibrosis induced by choline-deficient l-amino_acid-defined diet in rats .
26914659	0	Ipragliflozin	17,30	Sodium-Glucose_Co-transporter_2	34,65	Ipragliflozin	Sodium-Glucose Co-transporter 2	MESH:C572941	6524	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|compound|END_ENTITY	Effectiveness of Ipragliflozin , a Sodium-Glucose_Co-transporter_2 Inhibitor , as a Second-line Treatment for Non-Alcoholic Fatty Liver_Disease Patients with Type_2_Diabetes_Mellitus Who Do Not Respond to Incretin-Based Therapies Including Glucagon-like_Peptide-1 Analogs and Dipeptidyl_Peptidase-4 Inhibitors .
23563279	0	Ipragliflozin	0,13	sodium-glucose_cotransporter-2	24,54	Ipragliflozin	sodium-glucose cotransporter-2	MESH:C572941	6524	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Ipragliflozin and other sodium-glucose_cotransporter-2 -LRB- SGLT2 -RRB- inhibitors in the treatment of type 2 diabetes : preclinical and clinical data .
25685284	0	Ipragliflozin	0,13	sodium-glucose_cotransporter_2	23,53	Ipragliflozin	sodium-glucose cotransporter 2	MESH:C572941	6524	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Ipragliflozin : A novel sodium-glucose_cotransporter_2 inhibitor developed in Japan .
27025708	0	Ipragliflozin	0,13	sodium-glucose_cotransporter_2	17,47	Ipragliflozin	sodium-glucose cotransporter 2	MESH:C572941	64522(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Ipragliflozin , a sodium-glucose_cotransporter_2 inhibitor , ameliorates the development of liver_fibrosis in diabetic Otsuka Long-Evans Tokushima fatty rats .
16625543	0	Ipratropium_bromide	0,19	beta-2	40,46	Ipratropium bromide	beta-2	MESH:D009241	10242	Chemical	Gene	START_ENTITY|nmod|agonists agonists|amod|END_ENTITY	Ipratropium_bromide versus short acting beta-2 agonists for stable chronic_obstructive_pulmonary_disease .
16856113	0	Ipratropium_bromide	0,19	beta-2	39,45	Ipratropium bromide	beta-2	MESH:D009241	10242	Chemical	Gene	START_ENTITY|nmod|agonists agonists|amod|END_ENTITY	Ipratropium_bromide versus long-acting beta-2 agonists for stable chronic_obstructive_pulmonary_disease .
15852487	0	Ipriflavone	0,11	IGF-I	22,27	Ipriflavone	IGF-I	MESH:C018986	24482(Tax:10116)	Chemical	Gene	modulates|amod|START_ENTITY END_ENTITY|nsubj|modulates	Ipriflavone modulates IGF-I but is unable to restore bone in rats .
7870997	0	Ipsapirone	0,10	5-HT1A	87,93	Ipsapirone	5-HT1A	MESH:C043077	24473(Tax:10116)	Chemical	Gene	reduce|nsubj|START_ENTITY reduce|dobj|preference preference|dep|involvement involvement|nmod|receptors receptors|amod|END_ENTITY	Ipsapirone and 8-OH-DPAT reduce ethanol preference in rats : involvement of presynaptic 5-HT1A receptors .
8813534	0	Ipsapirone	0,10	5-HT1A	45,51	Ipsapirone	5-HT1A	MESH:C043077	24473(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|outflow outflow|nmod|receptors receptors|nummod|END_ENTITY	Ipsapirone enhances the dopamine outflow via 5-HT1A receptors in the rat prefrontal cortex .
8840346	0	Ipsapirone	0,10	5-HT1A	14,20	Ipsapirone	5-HT1A	MESH:C043077	3350	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Ipsapirone , a 5-HT1A agonist , suppresses REM sleep equally in unmedicated depressed patients and normal controls .
6195108	0	Ir	11,13	insulin	65,72	Ir	insulin	null	280829(Tax:9913)	Chemical	Gene	control|nsubj|START_ENTITY control|nmod|END_ENTITY	RT1-linked Ir and Is genes control the immune response to bovine insulin in the rat .
12184030	1	Irbesartan	95,105	AT1	202,205	Irbesartan	AT1	MESH:C081309	185	Chemical	Gene	antagonist|nsubj|START_ENTITY antagonist|nmod|angiotensin_II_type_1_receptor angiotensin_II_type_1_receptor|appos|END_ENTITY	Irbesartan -LRB- SR_47436 ; BMS-186295 -RRB- is a selective non-peptide antagonist of angiotensin_II_type_1_receptor -LRB- AT1 -RRB- .
18687761	0	Irbesartan	0,10	BMP-2	37,42	Irbesartan	BMP-2	MESH:C081309	650	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|compound|END_ENTITY	Irbesartan attenuates Ang_II-induced BMP-2 expression in human umbilical vein endothelial cells .
21575596	0	Irbesartan	0,10	CCR2	67,71	Irbesartan	CCR2	MESH:C081309	729230	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|nmod|inhibition inhibition|nmod|END_ENTITY	Irbesartan attenuates ischemic brain_damage by inhibition of MCP-1 / CCR2 signaling pathway beyond AT receptor blockade .
26394118	0	Irbesartan	10,20	Chemerin	24,32	Irbesartan	Chemerin	MESH:C081309	297073(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of Irbesartan on Chemerin in the Renal Tissues of Diabetic Rats .
26400537	0	Irbesartan	0,10	ICAM-1	36,42	Irbesartan	ICAM-1	MESH:C081309	3383	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|END_ENTITY	Irbesartan attenuates TNF-a-induced ICAM-1 , VCAM-1 , and E-selectin expression through suppression of NF-kB pathway in HUVECs .
26027837	0	Irciniastatin_a	0,15	extracellular_signal-regulated_kinase	59,96	Irciniastatin a	extracellular signal-regulated kinase	MESH:C498383	5594	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|nmod|END_ENTITY	Irciniastatin_a induces potent and sustained activation of extracellular_signal-regulated_kinase and thereby promotes ectodomain shedding of tumor necrosis factor receptor 1 in human lung_carcinoma a549 cells .
24374121	0	Irinotecan	60,70	CPT-11	72,78	Irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	distribution|nmod|START_ENTITY evaluations|nmod|distribution evaluations|appos|END_ENTITY	Image-based evaluations of distribution and cytotoxicity of Irinotecan -LRB- CPT-11 -RRB- in a multi-compartment micro-cell coculture device .
8120919	0	Irinotecan	0,10	CPT-11	12,18	Irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	escalation|compound|START_ENTITY escalation|compound|END_ENTITY	Irinotecan -LRB- CPT-11 -RRB- high-dose escalation using intensive high-dose loperamide to control diarrhea .
21945893	0	Irinotecan	0,10	S-1	127,130	Irinotecan	S-1	MESH:C051890	5707	Chemical	Gene	START_ENTITY|nmod|agent agent|nmod|treatment treatment|nmod|gastric_cancer gastric_cancer|nmod|failure failure|nmod|END_ENTITY	Irinotecan as the key chemotherapeutic agent in second-line treatment of metastatic gastric_cancer after failure of first-line S-1 or S-1 / CDDP therapy .
12800608	0	Irinotecan	0,10	UGT1A1	45,51	Irinotecan	UGT1A1	MESH:C051890	54658	Chemical	Gene	treatment|compound|START_ENTITY treatment|nmod|patients patients|nmod|END_ENTITY	Irinotecan treatment in cancer patients with UGT1A1 polymorphisms .
17609585	0	Irinotecan	0,10	p53	21,24	Irinotecan	p53	MESH:C051890	7157	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Irinotecan activates p53 with its active metabolite , resulting in human hepatocellular_carcinoma apoptosis .
21733184	0	Irinotecan	0,10	steroid_and_xenobiotic_receptor	19,50	Irinotecan	steroid and xenobiotic receptor	MESH:C051890	8856	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Irinotecan induces steroid_and_xenobiotic_receptor -LRB- SXR -RRB- signaling to detoxification pathway in colon_cancer cells .
26870964	0	Irisin	0,6	Urotensin_II	26,38	Irisin	Urotensin II	null	10911	Chemical	Gene	Associated|nsubj|START_ENTITY Associated|nmod|END_ENTITY	Irisin is Associated with Urotensin_II and Protein Energy Wasting in Hemodialysis Patients .
8428931	0	Iron	0,4	5-lipoxygenase	22,36	Iron	5-lipoxygenase	MESH:D007501	240	Chemical	Gene	content|amod|START_ENTITY content|nmod|END_ENTITY	Iron content of human 5-lipoxygenase , effects of mutations regarding conserved histidine residues .
17936676	0	Iron	0,4	AP-1	54,58	Iron	AP-1	MESH:D007501	3725	Chemical	Gene	increases|nsubj|START_ENTITY increases|nmod|activation activation|nmod|END_ENTITY	Iron increases MMP-9 expression through activation of AP-1 via ERK/Akt pathway in human head and neck squamous_carcinoma cells .
26890748	0	Iron	0,4	Apolipoprotein_E	15,31	Iron	Apolipoprotein E	MESH:D007501	348	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Iron Regulates Apolipoprotein_E Expression and Secretion in Neurons and Astrocytes .
21292994	0	Iron	0,4	Atm	41,44	Iron	Atm	MESH:D007501	11920(Tax:10090)	Chemical	Gene	loading|compound|START_ENTITY loading|nmod|END_ENTITY	Iron loading and oxidative_stress in the Atm - / - mouse liver .
11264898	0	Iron	0,4	Bcl-2	13,18	Iron	Bcl-2	MESH:D007501	596	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Iron induces Bcl-2 expression in human dermal microvascular endothelial cells .
25835049	0	Iron	33,37	DCYTB	23,28	Iron	DCYTB	MESH:D007501	79901	Chemical	Gene	Metabolism|compound|START_ENTITY Duodenal_Cytochrome_b|nmod|Metabolism Duodenal_Cytochrome_b|appos|END_ENTITY	Duodenal_Cytochrome_b -LRB- DCYTB -RRB- in Iron Metabolism : An Update on Function and Regulation .
11925462	0	Iron	0,4	DMT1	29,33	Iron	DMT1	MESH:D007501	4891	Chemical	Gene	treatment|compound|START_ENTITY downregulates|nsubj|treatment downregulates|dobj|expression expression|compound|END_ENTITY	Iron treatment downregulates DMT1 and IREG1 mRNA expression in Caco-2 cells .
14531808	0	Iron	0,4	DMT1	69,73	Iron	DMT1	MESH:D007501	24906(Tax:10116)	Chemical	Gene	handling|compound|START_ENTITY handling|nmod|transporter transporter|appos|END_ENTITY	Iron handling and gene expression of the divalent metal transporter , DMT1 , in the kidney of the anemic Belgrade -LRB- b -RRB- rat .
20007457	0	Iron	0,4	DMT1	96,100	Iron	DMT1	MESH:D007501	4891	Chemical	Gene	supply|compound|START_ENTITY determines|nsubj|supply determines|dobj|distribution distribution|nmod|transporters transporters|amod|END_ENTITY	Iron supply determines apical/basolateral membrane distribution of intestinal iron transporters DMT1 and ferroportin_1 .
22068728	0	Iron	0,4	DMT1	78,82	Iron	DMT1	MESH:D007501	4891	Chemical	Gene	START_ENTITY|dep|inhibition inhibition|nmod|divalent_metal_transporter_1 divalent_metal_transporter_1|appos|END_ENTITY	Iron , copper , and zinc transport : inhibition of divalent_metal_transporter_1 -LRB- DMT1 -RRB- and human copper_transporter_1 -LRB- hCTR1 -RRB- by shRNA .
26464252	0	Iron	13,17	DMT1	37,41	Iron	DMT1	MESH:D007501	24906(Tax:10116)	Chemical	Gene	Supplementation|compound|START_ENTITY Supplementation|nmod|END_ENTITY	Influence of Iron Supplementation on DMT1 -LRB- IRE -RRB- - induced Transport of Lead by Brain Barrier Systems in vivo .
12016214	0	Iron	0,4	DNA-binding_protein	56,75	Iron	DNA-binding protein	MESH:D007501	18157783	Chemical	Gene	properties|compound|START_ENTITY properties|nmod|END_ENTITY	Iron and hydrogen_peroxide detoxification properties of DNA-binding_protein from starved cells .
25835049	0	Iron	33,37	Duodenal_Cytochrome_b	0,21	Iron	Duodenal Cytochrome b	MESH:D007501	79901	Chemical	Gene	Metabolism|compound|START_ENTITY END_ENTITY|nmod|Metabolism	Duodenal_Cytochrome_b -LRB- DCYTB -RRB- in Iron Metabolism : An Update on Function and Regulation .
26845567	0	Iron	26,30	Erythropoietin	10,24	Iron	Erythropoietin	MESH:D007501	13856(Tax:10090)	Chemical	Gene	Deficiency|appos|START_ENTITY Deficiency|compound|END_ENTITY	Effect of Erythropoietin , Iron Deficiency and Iron Overload on Liver Matriptase-2 -LRB- TMPRSS6 -RRB- Protein Content in Mice and Rats .
22639604	0	Iron	4,8	FEA1	31,35	Iron	FEA1	MESH:D007501	5719589(Tax:3055)	Chemical	Gene	Protein|compound|START_ENTITY Protein|appos|END_ENTITY	The Iron Assimilatory Protein , FEA1 , from Chlamydomonas_reinhardtii Facilitates Iron-Specific Metal Uptake in Yeast and Plants .
22993514	0	Iron	0,4	FEA1	111,115	Iron	FEA1	MESH:D007501	5719589(Tax:3055)	Chemical	Gene	Biofortification|compound|START_ENTITY Biofortification|dep|Gene Gene|appos|END_ENTITY	Iron Biofortification and Homeostasis in Transgenic Cassava Roots Expressing the Algal Iron Assimilatory Gene , FEA1 .
22993514	0	Iron	87,91	FEA1	111,115	Iron	FEA1	MESH:D007501	5719589(Tax:3055)	Chemical	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Iron Biofortification and Homeostasis in Transgenic Cassava Roots Expressing the Algal Iron Assimilatory Gene , FEA1 .
15447900	0	Iron	0,4	HFE	48,51	Iron	HFE	MESH:D007501	3077	Chemical	Gene	absorption|compound|START_ENTITY absorption|nmod|carriers carriers|nmod|mutation mutation|compound|END_ENTITY	Iron absorption by heterozygous carriers of the HFE C282Y mutation associated with hemochromatosis .
15464655	0	Iron	0,4	HFE	10,13	Iron	HFE	MESH:D007501	3077	Chemical	Gene	START_ENTITY|appos|gene gene|compound|END_ENTITY	Iron , the HFE gene , and hepatitis_C .
16174659	0	Iron	0,4	HFE	46,49	Iron	HFE	MESH:D007501	3077	Chemical	Gene	loading|compound|START_ENTITY loading|nmod|relatives relatives|nmod|homozygotes homozygotes|compound|END_ENTITY	Iron loading and morbidity among relatives of HFE C282Y homozygotes identified either by population genetic testing or presenting as patients .
17181986	0	Iron	0,4	HFE	77,80	Iron	HFE	MESH:D007501	3077	Chemical	Gene	Overload|compound|START_ENTITY Overload|nmod|Attention Attention|nmod|Patients Patients|compound|END_ENTITY	Iron Overload -LRB- with Attention to Genetic Testing and Diagnosis/Management of HFE Wild Type Patients -RRB- .
19254564	0	Iron	0,4	HFE	31,34	Iron	HFE	MESH:D007501	3077	Chemical	Gene	sensing|compound|START_ENTITY sensing|dep|END_ENTITY	Iron sensing as a partnership : HFE and transferrin_receptor_2 .
20675164	0	Iron	0,4	HFE	36,39	Iron	HFE	MESH:D007501	3077	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|nmod|macrophages macrophages|nmod|END_ENTITY	Iron metabolism in macrophages from HFE hemochromatosis patients .
21659727	0	Iron	0,4	HFE	53,56	Iron	HFE	MESH:D007501	3077	Chemical	Gene	chelation|nsubj|START_ENTITY chelation|nmod|hemochromatosis hemochromatosis|compound|END_ENTITY	Iron chelation with deferasirox in two patients with HFE hemochromatosis and chronic_anemia .
25520556	0	Iron	34,38	HFE	71,74	Iron	HFE	MESH:D007501	3077	Chemical	Gene	Class|compound|START_ENTITY Influence|nmod|Class Evidence|nmod|Influence I|nsubj|Evidence I|dobj|END_ENTITY	Evidence for the Influence of the Iron Regulatory MHC Class I Molecule HFE on Tumor Progression in Experimental Models and Clinical Populations .
25654085	0	Iron	47,51	HFE	0,3	Iron	HFE	MESH:D007501	3077	Chemical	Gene	Indices|compound|START_ENTITY Genotyping|nmod|Indices Genotyping|compound|END_ENTITY	HFE Genotyping in Patients with Elevated Serum Iron Indices and Liver_Diseases .
26501199	0	Iron	78,82	HFE	31,34	Iron	HFE	MESH:D007501	3077	Chemical	Gene	Overload|compound|START_ENTITY Risk|nmod|Overload Have|dobj|Risk Have|nsubj|Carriers Carriers|nmod|c. c.|compound|END_ENTITY	Carriers of the Complex Allele HFE c. -LSB- 187C > G ; 340 +4 T > C -RSB- Have Increased Risk of Iron Overload in S o Miguel Island Population -LRB- Azores , Portugal -RRB- .
19777608	0	Iron	0,4	HMOX1	15,20	Iron	HMOX1	MESH:D007501	3162	Chemical	Gene	increases|compound|START_ENTITY END_ENTITY|nsubj|increases	Iron increases HMOX1 and decreases hepatitis_C viral expression in HCV-expressing cells .
26610684	0	Iron	5,9	Heme	0,4	Iron	Heme	MESH:D007501	100307951(Tax:9913)	Chemical	Gene	Release|compound|START_ENTITY Release|compound|END_ENTITY	Heme Iron Release from Alginate Beads at In Vitro Simulated Gastrointestinal Conditions .
11943867	0	Iron	0,4	Hfe	71,74	Iron	Hfe	MESH:D007501	15216(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY impaired|nsubjpass|uptake impaired|nmod|mouse mouse|compound|END_ENTITY	Iron uptake from plasma transferrin by the duodenum is impaired in the Hfe knockout mouse .
19348938	0	Iron	0,4	Hfe	25,28	Iron	Hfe	MESH:D007501	15216(Tax:10090)	Chemical	Gene	study|amod|START_ENTITY study|nmod|tissues tissues|compound|END_ENTITY	Iron speciation study in Hfe knockout mice tissues : magnetic and ultrastructural characterisation .
25761647	0	Iron	0,4	Hfe	36,39	Iron	Hfe	MESH:D007501	3077	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|hepcidin hepcidin|nmod|END_ENTITY	Iron regulation of hepcidin through Hfe and Hjv : Common or distinct pathways ?
25778985	0	Iron	14,18	IRT1	29,33	Iron	IRT1	MESH:D007501	199	Chemical	Gene	Uptake|compound|START_ENTITY Uptake|nmod|END_ENTITY	Regulation of Iron Uptake by IRT1 : Endocytosis Pulls the Trigger .
17936676	0	Iron	0,4	MMP-9	15,20	Iron	MMP-9	MESH:D007501	4318	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Iron increases MMP-9 expression through activation of AP-1 via ERK/Akt pathway in human head and neck squamous_carcinoma cells .
12376346	0	Iron	0,4	MTP1	49,53	Iron	MTP1	MESH:D007501	30061	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Iron increases expression of iron-export protein MTP1 in lung cells .
26762582	0	Iron	40,44	Matriptase-2	64,76	Iron	Matriptase-2	MESH:D007501	164656	Chemical	Gene	Diseases|compound|START_ENTITY Options|nmod|Diseases Route|nmod|Options Route|dep|END_ENTITY	En Route to New Therapeutic Options for Iron Overload Diseases : Matriptase-2 as a Target for Kunitz-Type Inhibitors .
26845567	0	Iron	26,30	Matriptase-2	69,81	Iron	Matriptase-2	MESH:D007501	71753(Tax:10090)	Chemical	Gene	Deficiency|appos|START_ENTITY Effect|nmod|Deficiency END_ENTITY|nsubj|Effect	Effect of Erythropoietin , Iron Deficiency and Iron Overload on Liver Matriptase-2 -LRB- TMPRSS6 -RRB- Protein Content in Mice and Rats .
26972048	0	Iron	0,4	Mox	44,47	Iron	Mox	MESH:D007501	26002	Chemical	Gene	profile|compound|START_ENTITY profile|nmod|END_ENTITY	Iron gene expression profile in atherogenic Mox macrophages .
26968114	0	Iron	95,99	Myeloperoxidase	41,56	Iron	Myeloperoxidase	MESH:D007501	17523(Tax:10090)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Epigallocatechin-3-Gallate Inhibition of Myeloperoxidase and Its Counter-Regulation by Dietary Iron and Lipocalin_2 in Murine Model of Gut Inflammation .
26776506	0	Iron	34,38	NCOA4	0,5	Iron	NCOA4	MESH:D007501	27057(Tax:10090)	Chemical	Gene	Homeostasis|compound|START_ENTITY Homeostasis|compound|END_ENTITY	NCOA4 Deficiency Impairs Systemic Iron Homeostasis .
27037625	0	Iron	8,12	Nrf2	21,25	Iron	Nrf2	MESH:D007501	18024(Tax:10090)	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Ferrous Iron Induces Nrf2 Expression in Mouse Brain Astrocytes to Prevent Neurotoxicity .
24867923	0	Iron	111,115	OPT3	0,4	Iron	OPT3	MESH:D007501	827332(Tax:3702)	Chemical	Gene	Signaling|nmod|START_ENTITY Essential|nmod|Signaling Transporter|acl:relcl|Essential Transporter|nsubj|END_ENTITY	OPT3 Is a Phloem-Specific Iron Transporter That Is Essential for Systemic Iron Signaling and Redistribution of Iron and Cadmium in Arabidopsis .
24867923	0	Iron	111,115	OPT3	0,4	Iron	OPT3	MESH:D007501	827332(Tax:3702)	Chemical	Gene	Signaling|nmod|START_ENTITY Essential|nmod|Signaling Transporter|acl:relcl|Essential Transporter|nsubj|END_ENTITY	OPT3 Is a Phloem-Specific Iron Transporter That Is Essential for Systemic Iron Signaling and Redistribution of Iron and Cadmium in Arabidopsis .
24867923	0	Iron	26,30	OPT3	0,4	Iron	OPT3	MESH:D007501	827332(Tax:3702)	Chemical	Gene	Transporter|compound|START_ENTITY Transporter|nsubj|END_ENTITY	OPT3 Is a Phloem-Specific Iron Transporter That Is Essential for Systemic Iron Signaling and Redistribution of Iron and Cadmium in Arabidopsis .
24867923	0	Iron	26,30	OPT3	0,4	Iron	OPT3	MESH:D007501	827332(Tax:3702)	Chemical	Gene	Transporter|compound|START_ENTITY Transporter|nsubj|END_ENTITY	OPT3 Is a Phloem-Specific Iron Transporter That Is Essential for Systemic Iron Signaling and Redistribution of Iron and Cadmium in Arabidopsis .
24867923	0	Iron	74,78	OPT3	0,4	Iron	OPT3	MESH:D007501	827332(Tax:3702)	Chemical	Gene	Signaling|compound|START_ENTITY Essential|nmod|Signaling Transporter|acl:relcl|Essential Transporter|nsubj|END_ENTITY	OPT3 Is a Phloem-Specific Iron Transporter That Is Essential for Systemic Iron Signaling and Redistribution of Iron and Cadmium in Arabidopsis .
24867923	0	Iron	74,78	OPT3	0,4	Iron	OPT3	MESH:D007501	827332(Tax:3702)	Chemical	Gene	Signaling|compound|START_ENTITY Essential|nmod|Signaling Transporter|acl:relcl|Essential Transporter|nsubj|END_ENTITY	OPT3 Is a Phloem-Specific Iron Transporter That Is Essential for Systemic Iron Signaling and Redistribution of Iron and Cadmium in Arabidopsis .
25572394	0	Iron	30,34	Prion_Protein	0,13	Iron	Prion Protein	MESH:D007501	19122(Tax:10090)	Chemical	Gene	Uptake|compound|START_ENTITY Uptake|compound|END_ENTITY	Prion_Protein Promotes Kidney Iron Uptake via Its Ferrireductase Activity .
11829747	8	Iron	1204,1208	SMF3	1223,1227	Iron	AFT1	MESH:D007501	852809(Tax:4932)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Iron regulation of SMF3 was dramatically reduced , but not completely eliminated , in strains lacking both the AFT1 and AFT2 iron regulatory factors .
11945174	0	Iron	0,4	TGF-beta1	128,137	Iron	TGF-beta1	MESH:D007501	7040	Chemical	Gene	arrest|amod|START_ENTITY arrest|dep|association association|nmod|transforming_growth_factor_beta1 transforming_growth_factor_beta1|appos|END_ENTITY	Iron chelation-induced senescence-like growth arrest in hepatocyte cell lines : association of transforming_growth_factor_beta1 -LRB- TGF-beta1 -RRB- - mediated p27Kip1 expression .
15550525	0	Iron	0,4	TGF-beta1	92,101	Iron	TGF-beta1	MESH:D007501	59086(Tax:10116)	Chemical	Gene	chelation|compound|START_ENTITY suppress|nsubj|chelation suppress|dobj|upregulation upregulation|nmod|END_ENTITY	Iron chelation and a free radical scavenger suppress angiotensin_II-induced upregulation of TGF-beta1 in the heart .
1587306	0	Iron	0,4	THP-1	78,83	Iron	THP-1	MESH:D007501	2736	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|effects effects|nmod|END_ENTITY	Iron modulates interferon-gamma effects in the human myelomonocytic cell line THP-1 .
11841920	0	Iron	0,4	TNFalpha	38,46	Iron	TNFalpha	MESH:D007501	7124	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Iron regulation of hepatic macrophage TNFalpha expression .
16429607	0	Iron	87,91	Transferrin	92,103	Iron	Transferrin	MESH:D007501	7018	Chemical	Gene	Oxalate|compound|START_ENTITY Oxalate|compound|END_ENTITY	Electron Spin Relaxation Rates for High-Spin Fe -LRB- III -RRB- in Iron Transferrin_Carbonate and Iron Transferrin Oxalate .
25290693	0	Iron	23,27	Transferrin	45,56	Iron	Transferrin	MESH:D007501	280705(Tax:9913)	Chemical	Gene	Acquisition|compound|START_ENTITY Acquisition|nmod|END_ENTITY	Pyrophosphate-Mediated Iron Acquisition from Transferrin in Neisseria_meningitidis Does Not Require TonB Activity .
25588002	0	Iron	17,21	Transferrin	55,66	Iron	Transferrin	MESH:D007501	7018	Chemical	Gene	Desaturation|nsubj|START_ENTITY Desaturation|compound|END_ENTITY	Decreased Plasma Iron in Alzheimer 's _ Disease Is Due to Transferrin Desaturation .
26131803	0	Iron	13,17	Transferrin	62,73	Iron	Transferrin	MESH:D007501	7018	Chemical	Gene	Deficiency_in_Inflammatory_Bowel_Disease|compound|START_ENTITY Diagnosis|nmod|Deficiency_in_Inflammatory_Bowel_Disease Diagnosis|nmod|Index Index|compound|END_ENTITY	Diagnosis of Iron Deficiency_in_Inflammatory_Bowel_Disease by Transferrin Receptor-Ferritin Index .
26024204	0	Iron	90,94	Tyrosine_Hydroxylase	98,118	Iron	Tyrosine Hydroxylase	MESH:D007501	7054	Chemical	Gene	Analysis|nmod|START_ENTITY Analysis|nmod|END_ENTITY	HYSCORE Analysis of the Effects of Substrates on Coordination of Water to the Active Site Iron in Tyrosine_Hydroxylase .
22556412	0	Iron	0,4	activation-induced_cytidine_deaminase	14,51	Iron	activation-induced cytidine deaminase	MESH:D007501	57379	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Iron inhibits activation-induced_cytidine_deaminase enzymatic activity and modulates immunoglobulin class switch DNA recombination .
1654090	0	Iron	0,4	apoferritin	29,40	Iron	apoferritin	MESH:D007501	100062811(Tax:9796)	Chemical	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	Iron binding to horse spleen apoferritin : a vanadyl ENDOR spin probe study .
1715280	0	Iron	0,4	apoferritin	33,44	Iron	apoferritin	MESH:D007501	100062811(Tax:9796)	Chemical	Gene	route|amod|START_ENTITY route|nmod|END_ENTITY	Iron entry route in horse spleen apoferritin .
2982843	0	Iron	0,4	apoferritin	19,30	Iron	apoferritin	MESH:D007501	2495	Chemical	Gene	deposition|nsubj|START_ENTITY deposition|nmod|END_ENTITY	Iron deposition in apoferritin .
3759957	0	Iron	0,4	apoferritin	24,35	Iron	apoferritin	MESH:D007501	2495	Chemical	Gene	incorporation|nsubj|START_ENTITY incorporation|nmod|END_ENTITY	Iron incorporation into apoferritin .
22068728	0	Iron	0,4	divalent_metal_transporter_1	48,76	Iron	divalent metal transporter 1	MESH:D007501	4891	Chemical	Gene	START_ENTITY|dep|inhibition inhibition|nmod|END_ENTITY	Iron , copper , and zinc transport : inhibition of divalent_metal_transporter_1 -LRB- DMT1 -RRB- and human copper_transporter_1 -LRB- hCTR1 -RRB- by shRNA .
21147099	0	Iron	0,4	dopamine_transporter	30,50	Iron	dopamine transporter	MESH:D007501	6531	Chemical	Gene	down-regulates|compound|START_ENTITY END_ENTITY|nsubj|down-regulates	Iron chelation down-regulates dopamine_transporter expression by decreasing mRNA stability and increasing endocytosis in N2a cells .
10037058	0	Iron	0,4	erythropoietin	46,60	Iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	depletion|nsubj|START_ENTITY depletion|nmod|phlebotomy phlebotomy|nmod|END_ENTITY	Iron depletion by phlebotomy with recombinant erythropoietin prior to allogeneic transplantation to prevent liver_toxicity .
10394459	0	Iron	1,5	erythropoietin	54,68	Iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	supplementation|compound|START_ENTITY treated|nsubj|supplementation treated|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Iron supplementation in preterm infants treated with erythropoietin -RSB- .
1361849	0	Iron	0,4	erythropoietin	58,72	Iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|END_ENTITY	Iron dextran treatment in peritoneal_dialysis patients on erythropoietin .
15737895	0	Iron	0,4	erythropoietin	21,35	Iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	requirements|amod|START_ENTITY requirements|nmod|therapy therapy|compound|END_ENTITY	Iron requirements in erythropoietin therapy .
16080798	0	Iron	0,4	erythropoietin	42,56	Iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	absorption|compound|START_ENTITY stress|nsubj|absorption stress|nmod|therapy therapy|compound|END_ENTITY	Iron absorption and oxidant stress during erythropoietin therapy in very low birth weight premature infants : a cohort study .
17373276	0	Iron	1,5	erythropoietin	34,48	Iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	pre|nsubj|START_ENTITY pre|dobj|-RSB- -RSB-|compound|END_ENTITY	-LSB- Iron metabolism pre and post the erythropoietin era -RSB- .
1747454	0	Iron	0,4	erythropoietin	41,55	Iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	balance|amod|START_ENTITY balance|nmod|therapy therapy|compound|END_ENTITY	Iron balance following recombinant human erythropoietin therapy for anemia associated with chronic_renal_failure .
1772785	0	Iron	0,4	erythropoietin	112,126	Iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	metabolism|nsubj|START_ENTITY metabolism|nmod|END_ENTITY	Iron metabolism in patients with the anaemia of end-stage_renal_disease during treatment with recombinant human erythropoietin .
2709674	0	Iron	0,4	erythropoietin	34,48	Iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	status|amod|START_ENTITY status|acl|receiving receiving|dobj|END_ENTITY	Iron status in patients receiving erythropoietin for dialysis-associated anemia .
2757026	0	Iron	0,4	erythropoietin	41,55	Iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	management|amod|START_ENTITY management|nmod|therapy therapy|compound|END_ENTITY	Iron management during recombinant human erythropoietin therapy .
7618648	0	Iron	0,4	erythropoietin	79,93	Iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	metabolism|compound|START_ENTITY indices|nsubj|metabolism indices|nmod|therapy therapy|compound|END_ENTITY	Iron metabolism indices for early prediction of the response and resistance to erythropoietin therapy in maintenance_hemodialysis patients .
7950165	0	Iron	0,4	erythropoietin	45,59	Iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|nmod|therapy therapy|compound|END_ENTITY	Iron metabolism and iron substitution during erythropoietin therapy .
8126248	0	Iron	0,4	erythropoietin	56,70	Iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	management|amod|START_ENTITY management|nmod|END_ENTITY	Iron management during treatment with recombinant human erythropoietin in chronic_renal_failure .
8184571	0	Iron	1,5	erythropoietin	84,98	Iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	stores|compound|START_ENTITY treated|nsubj|stores treated|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Iron stores in patients with chronic_kidney_failure treated with recombinant human erythropoietin -RSB- .
8904876	0	Iron	0,4	erythropoietin	27,41	Iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	deprivation|compound|START_ENTITY increases|nsubj|deprivation increases|dobj|production production|compound|END_ENTITY	Iron deprivation increases erythropoietin production in vitro , in normal subjects and patients with malignancy .
9029007	0	Iron	0,4	erythropoietin	92,106	Iron	erythropoietin	MESH:D007501	13856(Tax:10090)	Chemical	Gene	metabolism|nsubj|START_ENTITY metabolism|nmod|hypoplastic_anaemia_due_to_incomplete_deficiency hypoplastic_anaemia_due_to_incomplete_deficiency|nmod|END_ENTITY	Iron metabolism in transgenic_mice with hypoplastic_anaemia_due_to_incomplete_deficiency of erythropoietin .
9072885	0	Iron	1,5	erythropoietin	29,43	Iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	supplementation|nsubj|START_ENTITY supplementation|nmod|therapy therapy|compound|END_ENTITY	-LSB- Iron supplementation during erythropoietin therapy in patients on hemodialysis -RSB- .
9797624	0	Iron	0,4	erythropoietin	74,88	Iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	supplementation|compound|START_ENTITY enhances|nsubj|supplementation enhances|nmod|doses doses|nmod|END_ENTITY	Iron supplementation enhances response to high doses of recombinant human erythropoietin in preterm infants .
23787363	0	Iron	0,4	ferrochelatase	49,63	Iron	ferrochelatase	MESH:D007501	2235	Chemical	Gene	modulates|compound|START_ENTITY aberrant|nsubj|modulates aberrant|xcomp|splicing splicing|nmod|Jmjd6 Jmjd6|amod|END_ENTITY	Iron availability modulates aberrant splicing of ferrochelatase through the iron - and 2-oxoglutarate dependent dioxygenase Jmjd6 and U2AF -LRB- 65 . -RRB- .
12907459	0	Iron	0,4	ferroportin_1	46,59	Iron	ferroportin 1	MESH:D007501	30061	Chemical	Gene	loading|compound|START_ENTITY increase|nsubj|loading increase|dobj|expression expression|amod|END_ENTITY	Iron loading and erythrophagocytosis increase ferroportin_1 -LRB- FPN1 -RRB- expression in J774 macrophages .
15665091	0	Iron	0,4	ferroportin_1	75,88	Iron	ferroportin 1	MESH:D007501	53945(Tax:10090)	Chemical	Gene	release|nsubj|START_ENTITY release|advcl|up-regulated up-regulated|nmod|overexpression overexpression|amod|END_ENTITY	Iron release from macrophages after erythrophagocytosis is up-regulated by ferroportin_1 overexpression and down-regulated by hepcidin .
18974313	0	Iron	0,4	ferroportin_1	21,34	Iron	ferroportin 1	MESH:D007501	170840(Tax:10116)	Chemical	Gene	feeding|compound|START_ENTITY induces|nsubj|feeding induces|dobj|migration migration|amod|END_ENTITY	Iron feeding induces ferroportin_1 and hephaestin migration and interaction in rat duodenal epithelium .
25120608	0	Iron	0,4	ferroportin_1	33,46	Iron	ferroportin 1	MESH:D007501	30061	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Iron regulates the expression of ferroportin_1 in the cultured hFOB_1 .19 osteoblast cell line .
22068728	0	Iron	0,4	hCTR1	116,121	Iron	hCTR1	MESH:D007501	1317	Chemical	Gene	START_ENTITY|dep|inhibition inhibition|nmod|divalent_metal_transporter_1 divalent_metal_transporter_1|appos|END_ENTITY	Iron , copper , and zinc transport : inhibition of divalent_metal_transporter_1 -LRB- DMT1 -RRB- and human copper_transporter_1 -LRB- hCTR1 -RRB- by shRNA .
10101013	0	Iron	0,4	heme_oxygenase_1	41,57	Iron	heme oxygenase 1	MESH:D007501	3162	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Iron regulates hyperoxia-dependent human heme_oxygenase_1 gene expression in pulmonary endothelial cells .
23834908	0	Iron	0,4	hemoglobin	30,40	Iron	hemoglobin	MESH:D007501	541815(Tax:4577)	Chemical	Gene	bioavailability|amod|START_ENTITY bioavailability|nmod|END_ENTITY	Iron bioavailability of maize hemoglobin in a Caco-2 cell culture model .
1587306	0	Iron	0,4	interferon-gamma	15,31	Iron	interferon-gamma	MESH:D007501	3458	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|effects effects|amod|END_ENTITY	Iron modulates interferon-gamma effects in the human myelomonocytic cell line THP-1 .
12482971	0	Iron	0,4	lactoferrin	54,65	Iron	lactoferrin	MESH:D007501	17002(Tax:10090)	Chemical	Gene	status|amod|START_ENTITY status|acl|carrying carrying|dobj|disruption disruption|nmod|END_ENTITY	Iron status in mice carrying a targeted disruption of lactoferrin .
2345681	0	Iron	0,4	lactoferrin	28,39	Iron	lactoferrin	MESH:D007501	301034(Tax:10116)	Chemical	Gene	required|nsubjpass|START_ENTITY required|nmod|stimulation stimulation|compound|END_ENTITY	Iron is not required in the lactoferrin stimulation of thymidine incorporation into the DNA of rat crypt enterocytes .
8500909	0	Iron	0,4	lactoferrin	61,72	Iron	lactoferrin	MESH:D007501	280846(Tax:9913)	Chemical	Gene	acquisition|amod|START_ENTITY acquisition|dep|importance importance|nmod|END_ENTITY	Iron acquisition by Helicobacter_pylori : importance of human lactoferrin .
20719010	0	Iron	1,5	matriptase-2	34,46	Iron	matriptase-2	MESH:D007501	164656	Chemical	Gene	anaemia|compound|START_ENTITY anaemia|dep|due due|nmod|mutation mutation|amod|END_ENTITY	-LSB- Iron deficiency anaemia due to a matriptase-2 mutation -RSB- .
12688510	0	Iron	0,4	melanotransferrin	82,99	Iron	melanotransferrin	MESH:D007501	4241	Chemical	Gene	uptake|nsubj|START_ENTITY uptake|nmod|form form|nmod|homologue homologue|appos|END_ENTITY	Iron uptake by melanoma cells from the soluble form of the transferrin homologue , melanotransferrin .
26318828	0	Iron	0,4	neutrophil_gelatinase-associated_lipocalin	34,76	Iron	neutrophil gelatinase-associated lipocalin	MESH:D007501	3934	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|nmod|END_ENTITY	Iron metabolism and regulation by neutrophil_gelatinase-associated_lipocalin in cardiomyopathy .
26757915	0	Iron	0,4	neutrophil_gelatinase-associated_lipocalin	81,123	Iron	neutrophil gelatinase-associated lipocalin	MESH:D007501	3934	Chemical	Gene	depletion|nsubj|START_ENTITY depletion|parataxis|utilizing utilizing|dobj|roles roles|nmod|protein protein|amod|END_ENTITY	Iron depletion strategy for targeted cancer therapy : utilizing the dual roles of neutrophil_gelatinase-associated_lipocalin protein .
3172	0	Iron	0,4	phosvitin	44,53	Iron	phosvitin	MESH:D007501	100873151	Chemical	Gene	oxidation|compound|START_ENTITY oxidation|nmod|END_ENTITY	Iron oxidation and transferrin formation by phosvitin .
3711888	0	Iron	0,4	phosvitin	16,25	Iron	phosvitin	MESH:D007501	1460	Chemical	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	Iron binding by phosvitin : variation of rate of iron release as a function of the degree of saturation of iron binding sites .
7188938	0	Iron	0,4	phosvitin	16,25	Iron	phosvitin	MESH:D007501	1460	Chemical	Gene	binding|nsubj|START_ENTITY binding|nmod|END_ENTITY	Iron binding by phosvitin and its conformational consequences .
10772765	0	Iron	0,4	transferrin	19,30	Iron	transferrin	MESH:D007501	7018	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|synthesis synthesis|compound|END_ENTITY	Iron regulation of transferrin synthesis in the human hepatoma cell line HepG2 .
1080420	0	Iron	0,4	transferrin	18,29	Iron	transferrin	MESH:D007501	7018	Chemical	Gene	removal|nsubj|START_ENTITY removal|nmod|END_ENTITY	Iron removal from transferrin by a cell-free amphibian system .
11335103	0	Iron	0,4	transferrin	43,54	Iron	transferrin	MESH:D007501	7018	Chemical	Gene	uptake|nsubj|START_ENTITY uptake|nmod|END_ENTITY	Iron and gallium increase iron uptake from transferrin by human melanoma cells : further examination of the ferric_ammonium_citrate-activated iron uptake process .
11943867	0	Iron	0,4	transferrin	24,35	Iron	transferrin	MESH:D007501	22041(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|END_ENTITY	Iron uptake from plasma transferrin by the duodenum is impaired in the Hfe knockout mouse .
12688510	0	Iron	0,4	transferrin	59,70	Iron	transferrin	MESH:D007501	7018	Chemical	Gene	uptake|nsubj|START_ENTITY uptake|nmod|form form|nmod|homologue homologue|compound|END_ENTITY	Iron uptake by melanoma cells from the soluble form of the transferrin homologue , melanotransferrin .
12742718	0	Iron	0,4	transferrin	80,91	Iron	transferrin	MESH:D007501	7018	Chemical	Gene	acquisition|amod|START_ENTITY acquisition|dep|identification identification|nmod|proteins proteins|amod|END_ENTITY	Iron acquisition by Actinobacillus suis : identification and characterization of transferrin receptor proteins and encoding genes .
1415806	0	Iron	0,4	transferrin	27,38	Iron	transferrin	MESH:D007501	24825(Tax:10116)	Chemical	Gene	uptake|nsubj|START_ENTITY uptake|nmod|degradation degradation|compound|END_ENTITY	Iron uptake in relation to transferrin degradation in brain and other tissues of rats .
14972637	0	Iron	0,4	transferrin	23,34	Iron	transferrin	MESH:D007501	7018	Chemical	Gene	tests|amod|START_ENTITY tests|dep|vis vis|nsubj|receptor receptor|compound|END_ENTITY	Iron assessment tests : transferrin receptor vis - - vis zinc_protoporphyrin .
1530145	0	Iron	0,4	transferrin	17,28	Iron	transferrin	MESH:D007501	24825(Tax:10116)	Chemical	Gene	uptake|nsubj|START_ENTITY uptake|nmod|END_ENTITY	Iron uptake from transferrin and asialotransferrin by hepatocytes from chronically alcohol-fed rats .
1588135	0	Iron	0,4	transferrin	64,75	Iron	transferrin	MESH:D007501	7018	Chemical	Gene	acquisition|amod|START_ENTITY acquisition|dep|receptors receptors|nmod|END_ENTITY	Iron acquisition in Haemophilus_influenzae : receptors for human transferrin .
16113264	0	Iron	0,4	transferrin	22,33	Iron	transferrin	MESH:D007501	7018	Chemical	Gene	acquisition|amod|START_ENTITY acquisition|nmod|END_ENTITY	Iron acquisition from transferrin by Candida_albicans depends on the reductive pathway .
16798643	0	Iron	0,4	transferrin	23,34	Iron	transferrin	MESH:D007501	7018	Chemical	Gene	mobilization|nsubj|START_ENTITY mobilization|nmod|END_ENTITY	Iron mobilization from transferrin and non-transferrin-bound-iron by deferiprone .
17163184	0	Iron	1,5	transferrin	54,65	Iron	transferrin	MESH:D007501	7018	Chemical	Gene	status|nsubj|START_ENTITY status|nmod|consideration consideration|nmod|receptors receptors|compound|END_ENTITY	-LSB- Iron status with particular consideration of soluble transferrin receptors in children and youth with gastritis , with or without Helicobacter_pylori_infection -RSB- .
19087	0	Iron	0,4	transferrin	22,33	Iron	transferrin	MESH:D007501	7018	Chemical	Gene	exchange|amod|START_ENTITY exchange|nmod|molecules molecules|compound|END_ENTITY	Iron exchange between transferrin molecules mediated by phosphate compounds and other cell metabolites .
1945070	0	Iron	0,4	transferrin	23,34	Iron	transferrin	MESH:D007501	22041(Tax:10090)	Chemical	Gene	modulation|compound|START_ENTITY modulation|nmod|gene gene|compound|END_ENTITY	Iron modulation of the transferrin gene .
20133002	0	Iron	0,4	transferrin	24,35	Iron	transferrin	MESH:D007501	22041(Tax:10090)	Chemical	Gene	uptake|nsubj|START_ENTITY uptake|nmod|END_ENTITY	Iron uptake from plasma transferrin by a transferrin_receptor_2 mutant mouse model of haemochromatosis .
2039817	0	Iron	0,4	transferrin	93,104	Iron	transferrin	MESH:D007501	7018	Chemical	Gene	uptake|nsubj|START_ENTITY uptake|nmod|reticulocytes reticulocytes|nmod|concentrations concentrations|nmod|END_ENTITY	Iron uptake by human reticulocytes at physiologic and sub-physiologic concentrations of iron transferrin : the effect of interaction with aluminum_transferrin .
22155077	0	Iron	0,4	transferrin	23,34	Iron	transferrin	MESH:D007501	7018	Chemical	Gene	mobilization|nsubj|START_ENTITY mobilization|nmod|END_ENTITY	Iron mobilization from transferrin by therapeutic iron chelating agents .
2333967	0	Iron	0,4	transferrin	17,28	Iron	transferrin	MESH:D007501	24825(Tax:10116)	Chemical	Gene	uptake|nsubj|START_ENTITY uptake|nmod|END_ENTITY	Iron uptake from transferrin and lactoferrin by rat intestinal brush-border membrane vesicles .
2365453	0	Iron	0,4	transferrin	96,107	Iron	transferrin	MESH:D007501	280705(Tax:9913)	Chemical	Gene	acquisition|amod|START_ENTITY acquisition|dep|expression expression|nmod|receptor receptor|compound|END_ENTITY	Iron acquisition in Pasteurella_haemolytica : expression and identification of a bovine-specific transferrin receptor .
24418516	0	Iron	0,4	transferrin	47,58	Iron	transferrin	MESH:D007501	7018	Chemical	Gene	uptake|nsubj|START_ENTITY uptake|nmod|END_ENTITY	Iron uptake and transfer from ceruloplasmin to transferrin .
2490073	0	Iron	0,4	transferrin	18,29	Iron	transferrin	MESH:D007501	7018	Chemical	Gene	release|nsubj|START_ENTITY release|nmod|END_ENTITY	Iron release from transferrin induced by mixed ligand complexes of copper -LRB- II -RRB- .
3478338	0	Iron	0,4	transferrin	17,28	Iron	transferrin	MESH:D007501	7018	Chemical	Gene	uptake|nsubj|START_ENTITY uptake|nmod|cycle cycle|compound|END_ENTITY	Iron uptake from transferrin and transferrin endocytic cycle in Friend erythroleukemia cells .
3569539	0	Iron	0,4	transferrin	31,42	Iron	transferrin	MESH:D007501	7018	Chemical	Gene	transfer|nsubj|START_ENTITY transfer|nmod|END_ENTITY	Iron transfer from ferritin to transferrin .
3738220	0	Iron	0,4	transferrin	41,52	Iron	transferrin	MESH:D007501	24825(Tax:10116)	Chemical	Gene	absorption|compound|START_ENTITY absorption|nmod|END_ENTITY	Iron absorption and biliary excretion of transferrin in rats .
3772222	0	Iron	0,4	transferrin	18,29	Iron	transferrin	MESH:D007501	7018	Chemical	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	Iron release from transferrin : synergistic interaction between adenosine_triphosphate and an ammonium_sulfate fraction of hemolysate .
3817292	0	Iron	0,4	transferrin	82,93	Iron	transferrin	MESH:D007501	7018	Chemical	Gene	supports|nsubj|START_ENTITY supports|advcl|does does|dobj|END_ENTITY	Iron supports myogenic cell differentiation to the same degree as does iron-bound transferrin .
6377380	0	Iron	1,5	transferrin	51,62	Iron	transferrin	MESH:D007501	100009267(Tax:9986)	Chemical	Gene	content|compound|START_ENTITY content|nmod|blood blood|nmod|END_ENTITY	-LSB- Iron content of the blood and saturation of serum transferrin with iron as affected by roentgen rays -RSB- .
6517927	0	Iron	0,4	transferrin	17,28	Iron	transferrin	MESH:D007501	24825(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|END_ENTITY	Iron uptake from transferrin by isolated hepatocytes : effect of ethanol .
6734743	0	Iron	0,4	transferrin	54,65	Iron	transferrin	MESH:D007501	7018	Chemical	Gene	uptake|nsubj|START_ENTITY uptake|nmod|END_ENTITY	Iron uptake by Chinese_hamster fibroblasts from human transferrin .
711859	0	Iron	0,4	transferrin	28,39	Iron	transferrin	MESH:D007501	24825(Tax:10116)	Chemical	Gene	uptake|nsubj|START_ENTITY uptake|nmod|END_ENTITY	Iron uptake from rat plasma transferrin by rat reticulocytes .
728460	0	Iron	0,4	transferrin	32,43	Iron	transferrin	MESH:D007501	7018	Chemical	Gene	uptake|nsubj|START_ENTITY uptake|advcl|Chang Chang|dobj|cells cells|nmod|complexes complexes|compound|END_ENTITY	Iron uptake by Chang cells from transferrin , nitriloacetate and citrate complexes : the effects of iron-loading and chelation with desferrioxamine .
7578047	0	Iron	0,4	transferrin	58,69	Iron	transferrin	MESH:D007501	7018	Chemical	Gene	release|nsubj|START_ENTITY release|nmod|N-lobe N-lobe|nmod|END_ENTITY	Iron release from recombinant N-lobe and mutants of human transferrin .
7592626	0	Iron	0,4	transferrin	19,30	Iron	transferrin	MESH:D007501	7018	Chemical	Gene	START_ENTITY|acl|acquired acquired|nmod|END_ENTITY	Iron acquired from transferrin by K562 cells is delivered into a cytoplasmic pool of chelatable iron -LRB- II -RRB- .
7925932	0	Iron	0,4	transferrin	19,30	Iron	transferrin	MESH:D007501	7018	Chemical	Gene	START_ENTITY|acl|released released|nmod|END_ENTITY	Iron released from transferrin at acidic pH can catalyse the oxidation of low density lipoprotein .
870073	0	Iron	0,4	transferrin	18,29	Iron	transferrin	MESH:D007501	7018	Chemical	Gene	removal|amod|START_ENTITY removal|nmod|END_ENTITY	Iron removal from transferrin .
9371699	0	Iron	0,4	transferrin	77,88	Iron	transferrin	MESH:D007501	7018	Chemical	Gene	release|nsubj|START_ENTITY release|dobj|mutants mutants|nmod|END_ENTITY	Iron release from recombinant N-lobe and single point Asp63 mutants of human transferrin by EDTA .
18367876	0	Iron	0,4	transferrin_receptor	69,89	Iron	transferrin receptor	MESH:D007501	7037	Chemical	Gene	chelator-based|nsubj|START_ENTITY chelator-based|nmod|improved improved|nmod|END_ENTITY	Iron chelator-based amplification strategy for improved targeting of transferrin_receptor with SPIO .
9046063	0	Iron	0,4	transferrin_receptor	96,116	Iron	transferrin receptor	MESH:D007501	22042(Tax:10090)	Chemical	Gene	deprivation|compound|START_ENTITY deprivation|dep|view view|acl|beginning beginning|nmod|studies studies|nmod|antibodies antibodies|nmod|END_ENTITY	Iron deprivation and cancer : a view beginning with studies of monoclonal antibodies against the transferrin_receptor .
16935854	0	Iron	0,4	transferrin_receptor_2	59,81	Iron	transferrin receptor 2	MESH:D007501	50765(Tax:10090)	Chemical	Gene	absorption|compound|START_ENTITY increased|nsubjpass|absorption increased|nmod|model model|amod|END_ENTITY	Iron absorption and hepatic iron uptake are increased in a transferrin_receptor_2 -LRB- Y245X -RRB- mutant mouse model of hemochromatosis type 3 .
20133002	0	Iron	0,4	transferrin_receptor_2	41,63	Iron	transferrin receptor 2	MESH:D007501	50765(Tax:10090)	Chemical	Gene	uptake|nsubj|START_ENTITY uptake|nmod|model model|amod|END_ENTITY	Iron uptake from plasma transferrin by a transferrin_receptor_2 mutant mouse model of haemochromatosis .
21745449	0	Iron	0,4	transferrin_receptor_2	83,105	Iron	transferrin receptor 2	MESH:D007501	50765(Tax:10090)	Chemical	Gene	regulation|amod|START_ENTITY attenuated|nsubj|regulation attenuated|dobj|Smad1 Smad1|acl|signaling signaling|nmod|END_ENTITY	Iron regulation of hepcidin despite attenuated Smad1 ,5,8 signaling in mice without transferrin_receptor_2 or Hfe .
7539275	0	Iron	0,4	tumor_necrosis_factor-alpha	57,84	Iron	tumor necrosis factor-alpha	MESH:D007501	24835(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY species|nmod|response response|amod|END_ENTITY	Iron and reactive oxygen species in the asbestos-induced tumor_necrosis_factor-alpha response from alveolar macrophages .
7056739	0	Iron	0,4	uteroferrin	45,56	Iron	uteroferrin	MESH:D007501	397414(Tax:9823)	Chemical	Gene	transfer|nsubj|START_ENTITY transfer|nmod|END_ENTITY	Iron transfer between the purple phosphatase uteroferrin and transferrin and its possible role in iron metabolism of the fetal pig .
27040361	0	Iron_Together	0,13	Ceruloplasmin	57,70	Iron Together	Ceruloplasmin	null	12870(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|Levels Levels|nmod|END_ENTITY	Iron_Together with Lipid Downregulates Protein Levels of Ceruloplasmin in Macrophages Associated with Rapid Foam Cell Formation .
22053840	0	Iron_oxide	0,10	epidermal_growth_factor_receptor	32,64	Iron oxide	epidermal growth factor receptor	MESH:C000499	1956	Chemical	Gene	START_ENTITY|dobj|expression expression|compound|END_ENTITY	Iron_oxide nanoparticle-induced epidermal_growth_factor_receptor expression in human stem cells for tumor therapy .
12480089	0	Isatin	0,6	MAO	22,25	Isatin	MAO	MESH:D007510	29253(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Isatin , an endogenous MAO inhibitor , improves bradykinesia and dopamine levels in a rat model of Parkinson 's _ disease induced by Japanese_encephalitis_virus .
24316276	0	Isatin	66,72	tumor_necrosis_factor-alpha	14,41	Isatin	tumor necrosis factor-alpha	MESH:D007510	24835(Tax:10116)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of tumor_necrosis_factor-alpha and cyclooxigenase-2 by Isatin : a molecular mechanism of protection against TNBS-induced colitis in rats .
16116638	0	Isatoribine	0,11	TLR7	27,31	Isatoribine	TLR7	MESH:C061136	51284	Chemical	Gene	START_ENTITY|appos|agonist agonist|nmod|END_ENTITY	Isatoribine , an agonist of TLR7 , reduces plasma virus concentration in chronic hepatitis_C infection .
7495108	0	Isbogrel	30,38	CV-4151	21,28	Isbogrel	CV-4151	MESH:C045446	2549726(Tax:243365)	Chemical	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Beneficial effect of CV-4151 -LRB- Isbogrel -RRB- , a thromboxane_A2 synthase inhibitor , in a rat middle cerebral artery_thrombosis model .
24104352	0	Isoangustone_A	0,14	PI3K	84,88	Isoangustone A	PI3K	MESH:C551631	5293	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	Isoangustone_A , a novel licorice compound , inhibits cell proliferation by targeting PI3K , MKK4 , and MKK7 in human melanoma .
20167420	0	Isobavachalcone	31,46	Akt	14,17	Isobavachalcone	Akt	MESH:C468754	207	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Abrogation of Akt signaling by Isobavachalcone contributes to its anti-proliferative effects towards human cancer cells .
25704611	0	Isobavachalcone	0,15	ICAM-1	54,60	Isobavachalcone	ICAM-1	MESH:C468754	3383	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|compound|END_ENTITY	Isobavachalcone attenuates lipopolysaccharide-induced ICAM-1 expression in brain endothelial cells through blockade of toll-like_receptor_4 signaling pathways .
3363677	2	Isocitrate	310,320	DTNB	406,410	Isocitrate	DTNB	MESH:C034219	534119(Tax:9913)	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|END_ENTITY	Isocitrate rather than NADP and MnCl2 protects two SH-groups of the enzyme from modification by DTNB and attendant inactivation .
25432631	0	Isocitrate	0,10	IDH1	38,42	Isocitrate	IDH1	MESH:C034219	3417	Chemical	Gene	dehydrogenase|nsubj|START_ENTITY dehydrogenase|dobj|mutations mutations|appos|END_ENTITY	Isocitrate dehydrogenase 1 mutations -LRB- IDH1 -RRB- and p16/CDKN2A copy number change in conventional chondrosarcomas .
26904961	0	Isocryptotanshinone	0,19	STAT3	23,28	Isocryptotanshinone	STAT3	null	6774	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Isocryptotanshinone , a STAT3 inhibitor , induces apoptosis and pro-death autophagy in A549_lung_cancer cells .
22449077	0	Isodesacetyluvaricin	0,20	cyclooxygenase-2	90,106	Isodesacetyluvaricin	cyclooxygenase-2	MESH:C573518	5743	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Isodesacetyluvaricin , an Annonaceous acetogenin , specifically inhibits gene expression of cyclooxygenase-2 .
19203849	0	Isoflavone	0,10	vascular_endothelial_growth_factor_expression	21,66	Isoflavone	vascular endothelial growth factor expression	CHEBI:18220	83785(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Isoflavone regulates vascular_endothelial_growth_factor_expression in urinary tract of castrated rats .
16490810	0	Isoflavones	0,11	CYP2A6	60,66	Isoflavones	CYP2A6	MESH:D007529	1548	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|nmod|END_ENTITY	Isoflavones inhibit nicotine_C-oxidation catalyzed by human CYP2A6 .
26594764	0	Isoflavones	21,32	Glyoxalase_I	126,138	Isoflavones	Glyoxalase I	MESH:D007529	2739	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Inhibitory Effect of Isoflavones from Erythrina poeppigiana on the Growth of HL-60 Human Leukemia Cells through Inhibition of Glyoxalase_I .
27043500	0	Isoflavones	60,71	b-Cyclodextrin	40,54	Isoflavones	b-Cyclodextrin	MESH:D007529	285440	Chemical	Gene	Study|nmod|START_ENTITY Study|nmod|END_ENTITY	NMR Study on the Inclusion Complexes of b-Cyclodextrin with Isoflavones .
16249675	0	Isoflurane	0,10	Akt	101,104	Isoflurane	Akt	MESH:D007530	24185(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|activating activating|dobj|END_ENTITY	Isoflurane inhibits cardiac myocyte apoptosis during oxidative and inflammatory stress by activating Akt and enhancing Bcl-2 expression .
20053797	0	Isoflurane	0,10	TGF-beta1	15,24	Isoflurane	TGF-beta1	MESH:D007530	7040	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	Isoflurane via TGF-beta1 release increases caveolae formation and organizes sphingosine kinase signaling in renal proximal tubules .
12456428	0	Isoflurane	0,10	c-fos	41,46	Isoflurane	c-fos	MESH:D007530	314322(Tax:10116)	Chemical	Gene	depresses|nsubj|START_ENTITY depresses|dobj|expression expression|amod|END_ENTITY	Isoflurane , but not halothane , depresses c-fos expression in rat spinal cord at concentrations that suppress reflex movement after supramaximal noxious stimulation .
15595580	0	Isoflurane	0,10	cardiac_troponin_I	43,61	Isoflurane	cardiac troponin I	MESH:D007530	7137	Chemical	Gene	influence|nsubj|START_ENTITY influence|dobj|release release|compound|END_ENTITY	Isoflurane may not influence postoperative cardiac_troponin_I release and clinical outcome in adult cardiac surgery .
10592290	0	Isoflurane	0,10	dopamine_transporter	81,101	Isoflurane	dopamine transporter	MESH:D007530	6531	Chemical	Gene	anesthesia|compound|START_ENTITY enhances|nsubj|anesthesia enhances|nmod|END_ENTITY	Isoflurane anesthesia enhances the inhibitory effects of cocaine and GBR12909 on dopamine_transporter : PET studies in combination with microdialysis in the monkey brain .
15170819	0	Isoflurane	0,10	dopamine_transporter	19,39	Isoflurane	dopamine transporter	MESH:D007530	6531	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|trafficking trafficking|compound|END_ENTITY	Isoflurane induces dopamine_transporter trafficking into the cell cytoplasm .
15505448	0	Isoflurane	0,10	dopamine_transporter	32,52	Isoflurane	dopamine transporter	MESH:D007530	6531	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|amount amount|nmod|END_ENTITY	Isoflurane alters the amount of dopamine_transporter expressed on the plasma membrane in humans .
21453462	0	Isoflurane	0,10	heme_oxygenase-1	85,101	Isoflurane	heme oxygenase-1	MESH:D007530	24451(Tax:10116)	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|effects effects|nmod|reperfusion reperfusion|amod|END_ENTITY	Isoflurane preconditioning at clinically relevant doses induce protective effects of heme_oxygenase-1 on hepatic_ischemia reperfusion in rats .
23919323	0	Isoflurane	0,10	heme_oxygenase-1	87,103	Isoflurane	heme oxygenase-1	MESH:D007530	24451(Tax:10116)	Chemical	Gene	post-treatment|amod|START_ENTITY improves|nsubj|post-treatment improves|dobj|permeability permeability|nmod|upregulation upregulation|nmod|END_ENTITY	Isoflurane post-treatment improves pulmonary vascular permeability via upregulation of heme_oxygenase-1 .
23604542	0	Isoflurane	0,10	interleukin-6	36,49	Isoflurane	interleukin-6	MESH:D007530	16193(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|levels levels|amod|END_ENTITY	Isoflurane and sevoflurane increase interleukin-6 levels through the nuclear factor-kappa B pathway in neuroglioma cells .
24661914	0	Isoflurane	0,10	occludin	20,28	Isoflurane	occludin	MESH:D007530	100506658	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Isoflurane inhibits occludin expression via up-regulation of hypoxia-inducible_factor_1a .
20880454	0	Isoflurane	0,10	vascular_endothelial_growth_factor	33,67	Isoflurane	vascular endothelial growth factor	MESH:D007530	83785(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Isoflurane induces expression of vascular_endothelial_growth_factor through activating protein_kinase_C in myocardial cells .
20930381	0	Isofraxidin	0,11	matrix_metalloproteinase-7	73,99	Isofraxidin	matrix metalloproteinase-7	MESH:C008182	4316	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Isofraxidin , a coumarin component from Acanthopanax_senticosus , inhibits matrix_metalloproteinase-7 expression and cell invasion of human hepatoma cells .
17761896	0	Isoginkgetin	0,12	adiponectin	22,33	Isoginkgetin	adiponectin	MESH:C452984	9370	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|secretion secretion|compound|END_ENTITY	Isoginkgetin enhances adiponectin secretion from differentiated adiposarcoma_cells via a novel pathway involving AMP-activated protein kinase .
21314128	0	Isoindolinone	0,13	murine_double_minute_2	32,54	Isoindolinone	murine double minute 2	null	17246(Tax:10090)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Isoindolinone inhibitors of the murine_double_minute_2 -LRB- MDM2 -RRB- - p53 protein-protein interaction : structure-activity studies leading to improved potency .
610425	0	Isolated_acid	0,13	neuraminidase	14,27	Isolated acid	neuraminidase	null	4758	Chemical	Gene	deficiency|amod|START_ENTITY deficiency|compound|END_ENTITY	Isolated_acid neuraminidase deficiency : a distinct lysosomal_storage_disease .
17473376	0	Isoliquiritigenin	0,17	ErbB3	33,38	Isoliquiritigenin	ErbB3	MESH:C040920	2065	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Isoliquiritigenin -LRB- ISL -RRB- inhibits ErbB3 signaling in prostate_cancer cells .
26904149	0	Isoliquiritigenin	26,43	Nrf2	135,139	Isoliquiritigenin	Nrf2	MESH:C040920	4780	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|Activation Activation|compound|END_ENTITY	The Protective Effects of Isoliquiritigenin and Glycyrrhetinic_Acid against Triptolide-Induced Oxidative Stress in HepG2 Cells Involve Nrf2 Activation .
19169644	0	Isoliquiritigenin	0,17	heme_oxygenase-1	76,92	Isoliquiritigenin	heme oxygenase-1	MESH:C040920	3162	Chemical	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|amod|END_ENTITY	Isoliquiritigenin , from Dalbergia odorifera , up-regulates anti-inflammatory heme_oxygenase-1 expression in RAW264 .7 macrophages .
22959247	0	Isomannide	0,10	kallikrein_7	60,72	Isomannide	kallikrein 7	MESH:C502182	5650	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|inhibitors inhibitors|nmod|END_ENTITY	Isomannide derivatives as new class of inhibitors for human kallikrein_7 .
22846601	0	Isoniazid	0,9	myeloperoxidase	42,57	Isoniazid	myeloperoxidase	MESH:D007538	4353	Chemical	Gene	START_ENTITY|nmod|substrate substrate|nmod|END_ENTITY	Isoniazid as a substrate and inhibitor of myeloperoxidase : identification of amine adducts and the influence of superoxide dismutase on their formation .
26669106	0	Isoorientin	0,11	Cyclooxygenase-2	38,54	Isoorientin	Cyclooxygenase-2	MESH:C057912	5743	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|nmod|END_ENTITY	Isoorientin , a Selective Inhibitor of Cyclooxygenase-2 -LRB- COX-2 -RRB- from the Tubers_of_Pueraria_tuberosa .
26791751	0	Isoprenylated_Flavonoids	0,24	PTP1B	30,35	Isoprenylated Flavonoids	PTP1B	null	5770	Chemical	Gene	START_ENTITY|nmod|Inhibition Inhibition|compound|END_ENTITY	Isoprenylated_Flavonoids with PTP1B Inhibition from Macaranga denticulata .
26882676	0	Isoprenylated_Flavonoids	0,24	PTP1B	30,35	Isoprenylated Flavonoids	PTP1B	null	5770	Chemical	Gene	START_ENTITY|nmod|Inhibition Inhibition|compound|END_ENTITY	Isoprenylated_Flavonoids with PTP1B Inhibition from Ficus tikoua .
11112800	0	Isoproterenol	0,13	CREB	24,28	Isoproterenol	CREB	MESH:D007545	81646(Tax:10116)	Chemical	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	Isoproterenol increases CREB phosphorylation and olfactory nerve-evoked potentials in normal and 5-HT-depleted olfactory bulbs in rat pups only at doses that produce odor preference learning .
20207737	0	Isoproterenol	0,13	ERK	29,32	Isoproterenol	ERK	MESH:D007545	24338(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Isoproterenol and cAMP block ERK phosphorylation and enhance -LSB- Ca2 + -RSB- i increases and oxygen consumption by muscarinic receptor stimulation in rat parotid and submandibular acinar cells .
9443838	0	Isoproterenol	0,13	Il-10	23,28	Isoproterenol	Il-10	MESH:D007545	16153(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Isoproterenol inhibits Il-10 , TNF-alpha , and nitric_oxide production in RAW 264.7 macrophages .
9026523	0	Isoproterenol	0,13	LDL_receptor	24,36	Isoproterenol	LDL receptor	MESH:D007545	300438(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|compound|END_ENTITY	Isoproterenol decreases LDL_receptor expression in rat adipose cells : activation of cyclic_AMP-dependent proteolysis .
17027916	0	Isoproterenol	0,13	RANTES	42,48	Isoproterenol	RANTES	MESH:D007545	6352	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	Isoproterenol suppresses cytokine-induced RANTES secretion in human lung epithelial cells through the inhibition of c-jun_N-terminal_kinase pathway .
1531103	0	Isoproterenol	0,13	atrial_natriuretic_peptide	33,59	Isoproterenol	atrial natriuretic peptide	MESH:D007545	24602(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|release release|nmod|END_ENTITY	Isoproterenol induces release of atrial_natriuretic_peptide from rat atrium in vitro .
10827015	0	Isoproterenol	0,13	brain_natriuretic_peptide	47,72	Isoproterenol	brain natriuretic peptide	MESH:D007545	4879	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|gene gene|compound|END_ENTITY	Isoproterenol and cAMP regulation of the human brain_natriuretic_peptide gene involves Src and Rac .
8529629	0	Isoproterenol	0,13	insulin_receptor	74,90	Isoproterenol	insulin receptor	MESH:D007545	3643	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Isoproterenol inhibits insulin-stimulated tyrosine phosphorylation of the insulin_receptor without increasing its serine/threonine phosphorylation .
10348493	0	Isoproterenol	0,13	leptin	24,30	Isoproterenol	leptin	MESH:D007545	3952	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|compound|END_ENTITY	Isoproterenol decreases leptin expression in adipose tissue of obese humans .
14644552	0	Isoproterenol	0,13	lipoprotein_lipase	31,49	Isoproterenol	lipoprotein lipase	MESH:D007545	24539(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Isoproterenol increases active lipoprotein_lipase in adipocyte medium and in rat plasma .
22947212	0	Isoproterenol	0,13	matrix_metalloproteinase-2	24,50	Isoproterenol	matrix metalloproteinase-2	MESH:D007545	81686(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Isoproterenol modulates matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- and its tissue inhibitor-2 -LRB- TIMP-2 -RRB- in rat parotid gland .
16644035	0	Isoproterenol	0,13	monocyte_chemoattractant_protein-1	25,59	Isoproterenol	monocyte chemoattractant protein-1	MESH:D007545	6347	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Isoproterenol stimulates monocyte_chemoattractant_protein-1 expression and secretion in 3T3-L1 adipocytes .
11434927	0	Isoproterenol	0,13	resistin	23,31	Isoproterenol	resistin	MESH:D007545	56729	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Isoproterenol inhibits resistin gene expression through a G -LRB- S -RRB- - protein-coupled pathway in 3T3-L1 adipocytes .
11261622	0	Isoproterenol	0,13	tumor_necrosis_factor-alpha	74,101	Isoproterenol	tumor necrosis factor-alpha	MESH:D007545	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|nmod|END_ENTITY	Isoproterenol inhibits bacterial lipopolysaccharide-stimulated release of tumor_necrosis_factor-alpha from human heart tissue .
9038718	0	Isoproterenol	0,13	tumour_necrosis_factor	24,46	Isoproterenol	tumour necrosis factor	MESH:D007545	24835(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|amod|END_ENTITY	Isoproterenol regulates tumour_necrosis_factor , interleukin-10 , interleukin-6 and nitric_oxide production and protects against the development of vascular_hyporeactivity in endotoxaemia .
2994673	0	Isoproterenol	0,13	tyrosinase	27,37	Isoproterenol	tyrosinase	MESH:D007545	7299	Chemical	Gene	oxidation|amod|START_ENTITY oxidation|nmod|END_ENTITY	Isoproterenol oxidation by tyrosinase : intermediates characterization and kinetic study .
1078945	0	Isoproterenol	0,13	vasopressin	47,58	Isoproterenol	vasopressin	MESH:D007545	551	Chemical	Gene	START_ENTITY|nmod|effects effects|nmod|END_ENTITY	Isoproterenol in offsetting adverse effects of vasopressin in cirrhotic patients .
24490657	0	Isoquercitrin	0,13	AMP-activated_protein_kinase	28,56	Isoquercitrin	AMP-activated protein kinase	MESH:C016527	78975(Tax:10116)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|pathway pathway|amod|END_ENTITY	Isoquercitrin activates the AMP-activated_protein_kinase -LRB- AMPK -RRB- signal pathway in rat H4IIE cells .
26400396	0	Isoquinoline_Alkaloids	40,62	CYP2C19	29,36	Isoquinoline Alkaloids	CYP2C19	CHEBI:24921	1557	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Time-Dependent Inhibition of CYP2C19 by Isoquinoline_Alkaloids - In Vitro And In Silico Analysis .
24211276	0	Isorhamnetin	0,12	Nrf2	61,65	Isorhamnetin	Nrf2	MESH:C047368	4780	Chemical	Gene	protects|nsubj|START_ENTITY protects|advcl|activating activating|dobj|END_ENTITY	Isorhamnetin protects against oxidative stress by activating Nrf2 and inducing the expression of its target genes .
24398569	0	Isorhamnetin	0,12	mTOR	74,78	Isorhamnetin	mTOR	MESH:C047368	21977(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	Isorhamnetin suppresses colon_cancer cell growth through the PI3K - Akt - mTOR pathway .
16675095	0	Isosorbide_mononitrate	0,22	cyclooxygenase-2	64,80	Isosorbide mononitrate	cyclooxygenase-2	MESH:C030397	5743	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Isosorbide_mononitrate induces increased cervical expression of cyclooxygenase-2 , but not of cyclooxygenase-1 , at term .
18037290	0	Isothiazolidinone	0,17	PTP1B	32,37	Isothiazolidinone	PTP1B	MESH:C512915	5770	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Isothiazolidinone inhibitors of PTP1B containing imidazoles and imidazolines .
16227401	0	Isothiazolones	0,14	PCAF	32,36	Isothiazolones	PCAF	null	8850	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Isothiazolones as inhibitors of PCAF and p300 histone acetyltransferase activity .
21267493	0	Isothiazolones	0,14	cathepsin_B	63,74	Isothiazolones	cathepsin B	null	1508	Chemical	Gene	START_ENTITY|dep|inhibitors inhibitors|nmod|END_ENTITY	Isothiazolones ; thiol-reactive inhibitors of cysteine protease cathepsin_B and histone_acetyltransferase_PCAF .
25712054	0	Isothiocyanates	52,67	CXCR4	0,5	Isothiocyanates	CXCR4	MESH:D017879	12767(Tax:10090)	Chemical	Gene	Target|nmod|START_ENTITY Target|nsubj|END_ENTITY	CXCR4 Is a Novel Target of Cancer Chemopreventative Isothiocyanates in Prostate_Cancer Cells .
21466536	0	Isotretinoin	0,12	neutrophil_gelatinase-associated_lipocalin	46,88	Isotretinoin	neutrophil gelatinase-associated lipocalin	MESH:D015474	3934	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|nmod|END_ENTITY	Isotretinoin increases skin-surface levels of neutrophil_gelatinase-associated_lipocalin in patients treated for severe acne .
24900758	0	Isoxazole	39,48	BET	57,60	Isoxazole	BET	CHEBI:35595	92737	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|compound|END_ENTITY	Discovery , Design , and Optimization of Isoxazole Azepine BET Inhibitors .
23763364	0	Istaroxime	0,10	SERCA2a	22,29	Istaroxime	SERCA2a	MESH:C468128	403878(Tax:9615)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Istaroxime stimulates SERCA2a and accelerates calcium cycling in heart_failure by relieving phospholamban inhibition .
16004599	0	Istradefylline	0,14	adenosine_A2A_receptor	24,46	Istradefylline	adenosine A2A receptor	MESH:C111599	135	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Istradefylline , a novel adenosine_A2A_receptor antagonist , for the treatment of Parkinson 's _ disease .
24495175	0	Itraconazole	0,12	CXCL10	36,42	Itraconazole	CXCL10	MESH:D017964	3627	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Itraconazole inhibits TNF-a-induced CXCL10 expression in oral fibroblasts .
25907295	0	Itraconazole	0,12	P-glycoprotein	40,54	Itraconazole	P-glycoprotein	MESH:D017964	5243	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|activity activity|amod|END_ENTITY	Itraconazole and clarithromycin inhibit P-glycoprotein activity in primary human sinonasal epithelial cells .
20574995	0	Ivermectin	0,10	ABCG2	32,37	Ivermectin	ABCG2	MESH:D007559	9429	Chemical	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Ivermectin interacts with human ABCG2 .
11132606	0	J-105859	128,136	ETA	103,106	J-105859	ETA	MESH:C422782	1909	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	Marked reduction of mortality in salt-loaded Dahl salt-sensitive rats by the new , selective endothelin ETA receptor antagonist , J-105859 .
7647984	0	JB-9322	0,7	histamine_H2-receptor	25,46	JB-9322	histamine H2-receptor	MESH:C095323	100135540(Tax:10141)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	JB-9322 , a new selective histamine_H2-receptor antagonist with potent gastric mucosal protective properties .
11053478	0	JB3	0,3	IGF-I_receptor	8,22	JB3	IGF-I receptor	null	25718(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	JB3 , an IGF-I_receptor antagonist , inhibits early renal growth in diabetic and uninephrectomized rats .
22728397	0	JBP485	21,27	OAT1	81,85	JBP485	OAT1	MESH:C412308	9356	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|inhibition inhibition|nmod|END_ENTITY	Inhibitory effect of JBP485 on renal excretion of acyclovir by the inhibition of OAT1 and OAT3 .
22521734	0	JBP485	10,16	Oat1	75,79	JBP485	Oat1	MESH:C412308	29509(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY related|nsubjpass|Effect related|nmod|regulation regulation|nmod|END_ENTITY	Effect of JBP485 on obstructive_jaundice is related to regulation of renal Oat1 , Oat3 and Mrp2 expression in ANIT-treated rats .
22992436	0	JBP485	111,117	Oat1	31,35	JBP485	Oat1	MESH:C412308	29509(Tax:10116)	Chemical	Gene	Changes|nmod|START_ENTITY Changes|nmod|END_ENTITY	Changes in expression of renal Oat1 , Oat3 and Mrp2 in cisplatin-induced acute_renal_failure after treatment of JBP485 in rats .
23707770	0	JBP485	0,6	Oat1	100,104	JBP485	Oat1	MESH:C412308	29509(Tax:10116)	Chemical	Gene	improves|nsubj|START_ENTITY improves|advcl|regulating regulating|dobj|expression expression|nmod|END_ENTITY	JBP485 improves gentamicin-induced acute_renal_failure by regulating the expression and function of Oat1 and Oat3 in rats .
21262302	0	JBP485	36,42	PEPT1	46,51	JBP485	PEPT1	MESH:C412308	6564	Chemical	Gene	Uptake|nmod|START_ENTITY Uptake|nmod|END_ENTITY	Uptake , transport and regulation of JBP485 by PEPT1 in vitro and in vivo .
21310202	0	JBP485	11,17	PEPT1	52,57	JBP485	PEPT1	MESH:C412308	117261(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of JBP485 on the expression and function of PEPT1 in indomethacin-induced intestinal_injury in rats and damage in Caco-2 cells .
21712612	0	JBP485	47,53	PEPT1	105,110	JBP485	PEPT1	MESH:C412308	117261(Tax:10116)	Chemical	Gene	absorption|nmod|START_ENTITY zinc|nmod|absorption effect|nmod|zinc effect|appos|END_ENTITY	Inhibitory effect of zinc on the absorption of JBP485 via the gastrointestinal oligopeptide transporter -LRB- PEPT1 -RRB- in rats .
24903899	0	JBP485	48,54	PEPT1	191,196	JBP485	PEPT1	MESH:C412308	6564	Chemical	Gene	dipeptides|appos|START_ENTITY determination|nmod|dipeptides lysates|nsubj|determination lysates|parataxis|identify identify|dobj|function function|nmod|cell cell|compound|END_ENTITY	Simultaneous determination of three dipeptides -LRB- JBP485 , Gly-Sar and JBP923 -RRB- in the cell lysates by liquid chromatography-tandem mass spectrometry : application to identify the function of the PEPT1 transfected cell .
23899525	0	JGK-263	10,17	glycogen_synthase_kinase-3b	27,54	JGK-263	glycogen synthase kinase-3b	null	2932	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|amod|END_ENTITY	Effect of JGK-263 as a new glycogen_synthase_kinase-3b inhibitor on extrinsic apoptosis pathway in motor neuronal cells .
26365907	0	JI-101	17,23	VEGFR-2	41,48	JI-101	VEGFR-2	MESH:C561574	3791	Chemical	Gene	study|nmod|START_ENTITY study|appos|inhibitor inhibitor|nmod|END_ENTITY	A pilot study of JI-101 , an inhibitor of VEGFR-2 , PDGFR-b , and EphB4 receptors , in combination with everolimus and as a single agent in an ovarian_cancer expansion cohort .
9820175	0	JM216	57,62	cytochrome_P450	38,53	JM216	cytochrome P450	MESH:C081294	4051	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Potent and non-specific inhibition of cytochrome_P450 by JM216 , a new oral platinum agent .
26319159	0	JMV_2959	65,73	growth_hormone_secretagogue_receptor	12,48	JMV 2959	growth hormone secretagogue receptor	MESH:C569751	2693	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Blockade of growth_hormone_secretagogue_receptor 1A signaling by JMV_2959 attenuates the NMDAR antagonist , phencyclidine-induced impairments in prepulse inhibition .
16528290	0	JNJ-10280205	0,12	PDE5	37,41	JNJ-10280205	PDE5	MESH:C514864	8654	Chemical	Gene	START_ENTITY|dep|inhibitors inhibitors|compound|END_ENTITY	JNJ-10280205 and JNJ-10287069 : Novel PDE5 inhibitors as clinical candidates for erectile_dysfunction .
22300007	0	JNJ-26070109	46,58	CCK2_receptor	20,33	JNJ-26070109	CCK2 receptor	MESH:C560626	25706(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	The cholecystokinin CCK2_receptor antagonist , JNJ-26070109 , inhibits gastric_acid secretion and prevents omeprazole-induced acid rebound in the rat .
19682743	0	JNJ-26481585	37,49	histone_deacetylase	78,97	JNJ-26481585	histone deacetylase	MESH:C541788	9734	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Preclinical antileukemia activity of JNJ-26481585 , a potent second-generation histone_deacetylase inhibitor .
24038993	0	JNJ-26481585	77,89	histone_deacetylase	33,52	JNJ-26481585	histone deacetylase	MESH:C541788	9734	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Initial testing -LRB- stage 1 -RRB- of the histone_deacetylase inhibitor , quisinostat -LRB- JNJ-26481585 -RRB- , by the Pediatric Preclinical Testing Program .
23820125	0	JNJ-26854165	27,39	ABCA1	122,127	JNJ-26854165	ABCA1	MESH:C568210	19	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|inhibition inhibition|nmod|END_ENTITY	The novel anticancer agent JNJ-26854165 induces cell death through inhibition of cholesterol transport and degradation of ABCA1 .
16715516	0	JNJ-27553292	45,57	CCR2	61,65	JNJ-27553292	CCR2	null	729230	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Elucidation of the absolute configuration of JNJ-27553292 , a CCR2 receptor antagonist , by vibrational circular dichroism analysis of two precursors .
21145691	0	JNJ-31020028	77,89	neuropeptide_Y_Y2_receptor	38,64	JNJ-31020028	neuropeptide Y Y2 receptor	MESH:C547250	66024(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	The novel , selective , brain-penetrant neuropeptide_Y_Y2_receptor antagonist , JNJ-31020028 , tested in animal models of alcohol consumption , relapse , and anxiety .
22290934	0	JNJ-37822681	69,81	dopamine_D2_receptor	35,55	JNJ-37822681	dopamine D2 receptor	MESH:C576398	1813	Chemical	Gene	occupancy|nmod|START_ENTITY occupancy|amod|END_ENTITY	In vivo quantification of striatal dopamine_D2_receptor occupancy by JNJ-37822681 using -LSB- 11C -RSB- raclopride and positron emission tomography .
22340428	0	JNJ-38431055	11,23	GPR119	33,39	JNJ-38431055	GPR119	null	139760	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Effects of JNJ-38431055 , a novel GPR119 receptor agonist , in randomized , double-blind , placebo-controlled studies in subjects with type 2 diabetes .
25018015	0	JNJ-40929837	11,23	leukotriene_A4_hydrolase	27,51	JNJ-40929837	leukotriene A4 hydrolase	null	4048	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effects of JNJ-40929837 , a leukotriene_A4_hydrolase inhibitor , in a bronchial allergen challenge model of asthma .
26177655	0	JNJ-42847922	20,32	Orexin-2_Receptor	46,63	JNJ-42847922	Orexin-2 Receptor	null	25605(Tax:10116)	Chemical	Gene	START_ENTITY|appos|Antagonist Antagonist|compound|END_ENTITY	Characterization of JNJ-42847922 , a Selective Orexin-2_Receptor Antagonist , as a Clinical Candidate for the Treatment of Insomnia .
21122808	0	JNJ16259685	53,64	mGluR1	34,40	JNJ16259685	mGluR1	MESH:C495417	14799(Tax:10090)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Characterization of the selective mGluR1 antagonist , JNJ16259685 , in rodent models of movement and coordination .
18815616	0	JNJ39659100	61,72	PPAR-gamma	82,92	JNJ39659100	PPAR-gamma	null	5468	Chemical	Gene	START_ENTITY|dep|Agonist Agonist|compound|END_ENTITY	Cross-Species Differential Plasma Protein Binding of MBX-102 / JNJ39659100 : A Novel PPAR-gamma Agonist .
16939498	0	JSI-124	0,7	Janus_kinase-3	34,48	JSI-124	Janus kinase-3	MESH:C038106	3718	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|kinase kinase|amod|END_ENTITY	JSI-124 -LRB- cucurbitacin_I -RRB- inhibits Janus_kinase-3 / signal_transducer_and_activator_of_transcription-3 signalling , downregulates nucleophosmin-anaplastic_lymphoma kinase -LRB- ALK -RRB- , and induces apoptosis in ALK-positive_anaplastic_large_cell_lymphoma cells .
14623124	0	JTC-801	10,17	nociceptin	19,29	JTC-801	nociceptin	MESH:C433236	25516(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|antagonist antagonist|compound|END_ENTITY	Effect of JTC-801 -LRB- nociceptin antagonist -RRB- on neuropathic_pain in a rat model .
11815367	0	JTC-801	88,95	opioid_receptor-like1	36,57	JTC-801	opioid receptor-like1	MESH:C433236	4987	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	Pharmacological profiles of a novel opioid_receptor-like1 -LRB- ORL -LRB- 1 -RRB- -RRB- receptor antagonist , JTC-801 .
10604722	0	JTE-522	95,102	COX-2	78,83	JTE-522	COX-2	MESH:C110453	17709(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Inhibition of haematogenous metastasis of colon_cancer in mice by a selective COX-2 inhibitor , JTE-522 .
10783317	0	JTE-522	110,117	COX-2	93,98	JTE-522	COX-2	MESH:C110453	19225(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Suppression of polypogenesis in a new mouse_strain with a truncated Apc -LRB- Delta474 -RRB- by a novel COX-2 inhibitor , JTE-522 .
11285187	0	JTE-522	98,105	COX-2	119,124	JTE-522	COX-2	MESH:C110453	29527(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY Suppression|acl|induced Suppression|appos|inhibitor inhibitor|compound|END_ENTITY	Suppression of N-nitrosomethylbenzylamine -LRB- NMBA -RRB- - induced esophageal tumorigenesis in F344 rats by JTE-522 , a selective COX-2 inhibitor .
11906292	0	JTE-522	245,252	COX-2	229,234	JTE-522	COX-2	MESH:C110453	5743	Chemical	Gene	START_ENTITY|amod|selectivity selectivity|nmod|introduction introduction|nmod|atom atom|nmod|inhibitor inhibitor|compound|END_ENTITY	4 - -LRB- 4-cycloalkyl/aryl-oxazol -5 - yl -RRB- benzenesulfonamides as selective cyclooxygenase-2 inhibitors : enhancement of the selectivity by introduction of a fluorine atom and identification of a potent , highly selective , and orally active COX-2 inhibitor JTE-522 -LRB- 1 -RRB- .
12100758	0	JTE-522	0,7	COX-2	21,26	JTE-522	COX-2	MESH:C110453	4513	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	JTE-522 , a selective COX-2 inhibitor , inhibits cell proliferation and induces apoptosis in RL95-2 cells .
15386343	0	JTE-522	0,7	COX-2	21,26	JTE-522	COX-2	MESH:C110453	26198(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	JTE-522 , a selective COX-2 inhibitor , interferes with the growth of lung metastases from colorectal_cancer in rats due to inhibition_of_neovascularization : a vascular cast model study .
15743541	0	JTE-522	0,7	COX-2	21,26	JTE-522	COX-2	MESH:C110453	26198(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	JTE-522 , a selective COX-2 inhibitor , inhibits growth of pulmonary metastases of colorectal_cancer in rats .
11205258	0	JTE-522	26,33	cyclooxygenase-2	46,62	JTE-522	cyclooxygenase-2	MESH:C110453	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Induction of apoptosis by JTE-522 , a specific cyclooxygenase-2 inhibitor , in human gastric_cancer cell lines .
11906292	0	JTE-522	245,252	cyclooxygenase-2	66,82	JTE-522	cyclooxygenase-2	MESH:C110453	5743	Chemical	Gene	enhancement|nmod|START_ENTITY 4|dep|enhancement 4|dep|benzenesulfonamides benzenesulfonamides|nmod|inhibitors inhibitors|amod|END_ENTITY	4 - -LRB- 4-cycloalkyl/aryl-oxazol -5 - yl -RRB- benzenesulfonamides as selective cyclooxygenase-2 inhibitors : enhancement of the selectivity by introduction of a fluorine atom and identification of a potent , highly selective , and orally active COX-2 inhibitor JTE-522 -LRB- 1 -RRB- .
12445023	0	JTE-522	31,38	cyclooxygenase-2	58,74	JTE-522	cyclooxygenase-2	MESH:C110453	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Pharmacokinetics and safety of JTE-522 , a novel selective cyclooxygenase-2 inhibitor , in healthy male volunteers .
12891558	0	JTE-522	0,7	cyclooxygenase-2	11,27	JTE-522	cyclooxygenase-2	MESH:C110453	29527(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	JTE-522 , a cyclooxygenase-2 inhibitor , is an effective chemopreventive agent against rat experimental liver_fibrosis1 .
14643021	0	JTE-522	26,33	cyclooxygenase-2	47,63	JTE-522	cyclooxygenase-2	MESH:C110453	29527(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|inhibitor inhibitor|amod|END_ENTITY	Chemopreventive effect of JTE-522 , a selective cyclooxygenase-2 inhibitor , on 1 , _ 2-dimethylhydrazine-induced rat colon_carcinogenesis .
15373703	0	JTE-522	71,78	cyclooxygenase-2	92,108	JTE-522	cyclooxygenase-2	MESH:C110453	29527(Tax:10116)	Chemical	Gene	Inhibition|amod|START_ENTITY Inhibition|appos|inhibitor inhibitor|amod|END_ENTITY	Inhibition of azoxymethane-induced colon_carcinogenesis in rats due to JTE-522 , a selective cyclooxygenase-2 inhibitor .
15455344	0	JTE-522	0,7	cyclooxygenase-2	21,37	JTE-522	cyclooxygenase-2	MESH:C110453	29527(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	JTE-522 , a selective cyclooxygenase-2 inhibitor , inhibits induction but not growth and invasion of 1,2-dimethylhydrazine-induced tubular_adenocarcinomas of colon in rats .
17914586	0	JTE-522	43,50	cyclooxygenase-2	64,80	JTE-522	cyclooxygenase-2	MESH:C110453	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Mechanisms of anti-proliferative effect of JTE-522 , a selective cyclooxygenase-2 inhibitor , on human liver_cancer cells .
20434301	0	JTE-522	21,28	cyclooxygenase-2	42,58	JTE-522	cyclooxygenase-2	MESH:C110453	29527(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Preventive effect of JTE-522 , a selective cyclooxygenase-2 inhibitor , on DEN-induced hepatocarcinogenesis in rats .
9600662	0	JTE-522	11,18	cyclooxygenase-2	44,60	JTE-522	cyclooxygenase-2	MESH:C110453	29527(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|inhibitor inhibitor|nmod|END_ENTITY	Effects of JTE-522 , a specific inhibitor of cyclooxygenase-2 , on the recurrence of allergic_inflammation in rats .
9869271	0	JTE-522	11,18	cyclooxygenase-2	30,46	JTE-522	cyclooxygenase-2	MESH:C110453	5743	Chemical	Gene	Profile|nmod|START_ENTITY Profile|nmod|inhibitor inhibitor|amod|END_ENTITY	Profile of JTE-522 as a human cyclooxygenase-2 inhibitor .
10616795	0	JTP-2942	10,18	thyrotropin-releasing_hormone	28,57	JTP-2942	thyrotropin-releasing hormone	MESH:C080784	25569(Tax:10116)	Chemical	Gene	START_ENTITY|appos|analog analog|amod|END_ENTITY	Effect of JTP-2942 , a novel thyrotropin-releasing_hormone analog , on motor_deficits after chronic focal cerebral_ischemia in rats .
11368951	0	JTP-2942	38,46	thyrotropin-releasing_hormone	56,85	JTP-2942	thyrotropin-releasing hormone	MESH:C080784	25569(Tax:10116)	Chemical	Gene	START_ENTITY|appos|analogue analogue|amod|END_ENTITY	Effect of long-term administration of JTP-2942 , a novel thyrotropin-releasing_hormone analogue , on neurological outcome , local cerebral blood flow and glucose utilization in a rat focal cerebral_ischemia .
7781687	0	JTP-2942	10,18	thyrotropin-releasing_hormone	28,57	JTP-2942	thyrotropin-releasing hormone	MESH:C080784	25569(Tax:10116)	Chemical	Gene	START_ENTITY|appos|analogue analogue|amod|END_ENTITY	Effect of JTP-2942 , a novel thyrotropin-releasing_hormone analogue , on pentobarbital-induced anesthesia in rats .
8472746	0	JTP-2942	59,67	thyrotropin-releasing_hormone	19,48	JTP-2942	thyrotropin-releasing hormone	MESH:C080784	25569(Tax:10116)	Chemical	Gene	analogue|appos|START_ENTITY analogue|amod|END_ENTITY	Effects of a novel thyrotropin-releasing_hormone analogue , JTP-2942 , on extracellular acetylcholine and choline levels in the rat frontal cortex and hippocampus .
9696053	0	JTP-2942	0,8	thyrotropin-releasing_hormone	18,47	JTP-2942	thyrotropin-releasing hormone	MESH:C080784	22044(Tax:10090)	Chemical	Gene	START_ENTITY|appos|analogue analogue|amod|END_ENTITY	JTP-2942 , a novel thyrotropin-releasing_hormone analogue , protects against spinal motor neuron_degeneration in the wobbler mouse .
7540663	0	JTP-4819	50,58	prolyl_endopeptidase	18,38	JTP-4819	prolyl endopeptidase	MESH:C094211	83471(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY END_ENTITY|dobj|inhibitor	Effect of a novel prolyl_endopeptidase inhibitor , JTP-4819 , on prolyl_endopeptidase activity and substance P - and arginine-vasopressin-like immunoreactivity in the brains of aged rats .
7540663	0	JTP-4819	50,58	prolyl_endopeptidase	63,83	JTP-4819	prolyl endopeptidase	MESH:C094211	83471(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|nmod|activity activity|amod|END_ENTITY	Effect of a novel prolyl_endopeptidase inhibitor , JTP-4819 , on prolyl_endopeptidase activity and substance P - and arginine-vasopressin-like immunoreactivity in the brains of aged rats .
9062674	0	JTP-4819	40,48	prolyl_endopeptidase	8,28	JTP-4819	prolyl endopeptidase	MESH:C094211	83471(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY END_ENTITY|dobj|inhibitor	A novel prolyl_endopeptidase inhibitor , JTP-4819 , with potential for treating Alzheimer 's _ disease .
9205821	0	JTP-4819	31,39	prolyl_endopeptidase	72,92	JTP-4819	prolyl endopeptidase	MESH:C094211	5550	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Pharmacokinetics and safety of JTP-4819 , a novel specific orally active prolyl_endopeptidase inhibitor , in healthy male volunteers .
9476982	0	JTP-4819	44,52	prolyl_endopeptidase	12,32	JTP-4819	prolyl endopeptidase	MESH:C094211	83471(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Effect of a prolyl_endopeptidase inhibitor , JTP-4819 , on radial maze performance in hippocampal-lesioned rats .
9683325	0	JTP-4819	40,48	prolyl_endopeptidase	8,28	JTP-4819	prolyl endopeptidase	MESH:C094211	5550	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	A novel prolyl_endopeptidase inhibitor , JTP-4819 -- its behavioral and neurochemical properties for the treatment of Alzheimer 's _ disease .
23728381	0	JTS-653	48,55	TRPV1	30,35	JTS-653	TRPV1	MESH:C576953	83810(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	Orally administered selective TRPV1 antagonist , JTS-653 , attenuates chronic_pain refractory to non-steroidal anti-inflammatory drugs in rats and mice including post-herpetic pain .
21139060	0	JTT-130	0,7	microsomal_triglyceride_transfer_protein	49,89	JTT-130	microsomal triglyceride transfer protein	MESH:C556241	310900(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	JTT-130 , a novel intestine-specific inhibitor of microsomal_triglyceride_transfer_protein , suppresses food intake and gastric emptying with the elevation of plasma peptide_YY and glucagon-like_peptide-1 in a dietary fat-dependent manner .
21255216	0	JTT-130	0,7	microsomal_triglyceride_transfer_protein	49,89	JTT-130	microsomal triglyceride transfer protein	MESH:C556241	310900(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	JTT-130 , a novel intestine-specific inhibitor of microsomal_triglyceride_transfer_protein , suppresses high fat diet-induced obesity and glucose_intolerance in Sprague-Dawley_rats .
21362121	0	JTT-130	0,7	microsomal_triglyceride_transfer_protein	49,89	JTT-130	microsomal triglyceride transfer protein	MESH:C556241	310900(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	JTT-130 , a novel intestine-specific inhibitor of microsomal_triglyceride_transfer_protein , ameliorates impaired_glucose_and_lipid_metabolism in Zucker diabetic fatty rats .
21810422	0	JTT-305	0,7	calcium-sensing_receptor	26,50	JTT-305	calcium-sensing receptor	MESH:C568849	24247(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	JTT-305 , an orally active calcium-sensing_receptor antagonist , stimulates transient parathyroid_hormone release and bone formation in ovariectomized rats .
21810422	0	JTT-305	0,7	parathyroid_hormone	84,103	JTT-305	parathyroid hormone	MESH:C568849	24694(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|compound|END_ENTITY	JTT-305 , an orally active calcium-sensing_receptor antagonist , stimulates transient parathyroid_hormone release and bone formation in ovariectomized rats .
20380650	0	JTT-551	79,86	protein_tyrosine_phosphatase_1B	36,67	JTT-551	protein tyrosine phosphatase 1B	MESH:C556903	19246(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Pharmacological profiles of a novel protein_tyrosine_phosphatase_1B inhibitor , JTT-551 .
24987707	0	JTT-551	27,34	protein_tyrosine_phosphatase_1B	44,75	JTT-551	protein tyrosine phosphatase 1B	MESH:C556903	19246(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Pharmacological effects of JTT-551 , a novel protein_tyrosine_phosphatase_1B inhibitor , in diet-induced obesity mice .
11994249	0	JTT-705	77,84	cholesteryl_ester_transfer_protein	31,65	JTT-705	cholesteryl ester transfer protein	MESH:C411602	1071	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Efficacy and safety of a novel cholesteryl_ester_transfer_protein inhibitor , JTT-705 , in humans : a randomized phase II dose-response study .
12679151	0	JTT-705	10,17	cholesteryl_ester_transfer_protein	21,55	JTT-705	cholesteryl ester transfer protein	MESH:C411602	1071	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|compound|END_ENTITY	Effect of JTT-705 on cholesteryl_ester_transfer_protein and plasma lipid levels in normolipidemic animals .
15331428	0	JTT-705	61,68	cholesteryl_ester_transfer_protein	14,48	JTT-705	cholesteryl ester transfer protein	MESH:C411602	100327267(Tax:9986)	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Inhibition of cholesteryl_ester_transfer_protein activity by JTT-705 increases apolipoprotein_E-containing high-density lipoprotein and favorably affects the function and enzyme composition of high-density lipoprotein in rabbits .
15842977	0	JTT-705	69,76	cholesteryl_ester_transfer_protein	31,65	JTT-705	cholesteryl ester transfer protein	MESH:C411602	1071	Chemical	Gene	Effectiveness|nmod|START_ENTITY Effectiveness|nmod|END_ENTITY	Effectiveness of inhibition of cholesteryl_ester_transfer_protein by JTT-705 in combination with pravastatin in type_II_dyslipidemia .
11675032	0	JTV-803	21,28	factor_Xa	68,77	JTV-803	factor Xa	MESH:C442639	2159	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Inhibitory effect of JTV-803 , a new cyclic_guanidine derivative , on factor_Xa in vitro and in vivo .
12516682	0	JTV-803	44,51	factor_Xa	23,32	JTV-803	factor Xa	MESH:C442639	2159	Chemical	Gene	Effects|appos|START_ENTITY Effects|nmod|inhibitor inhibitor|compound|END_ENTITY	Effects of a synthetic factor_Xa inhibitor -LRB- JTV-803 -RRB- on various laboratory tests .
17185040	0	JWH-015	34,41	CB2	0,3	JWH-015	CB2	MESH:C402944	1269	Chemical	Gene	agonist|appos|START_ENTITY agonist|nummod|END_ENTITY	CB2 cannabinoid receptor agonist , JWH-015 , triggers apoptosis in immune cells : potential role for CB2-selective ligands as immunosuppressive agents .
26842917	0	JWH-133	0,7	CB2	33,36	JWH-133	CB2	MESH:C432747	1269	Chemical	Gene	START_ENTITY|appos|Agonist Agonist|compound|END_ENTITY	JWH-133 , a Selective Cannabinoid CB2 Receptor Agonist , Exerts Toxic Effects on Neuroblastoma SH-SY5Y Cells .
22921769	0	JWH015	27,33	CB1	76,79	JWH015	CB1	MESH:C402944	12801(Tax:10090)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	The CB2-preferring agonist JWH015 also potently and efficaciously activates CB1 in autaptic hippocampal neurons .
17912054	0	JWH133	80,86	CB2	46,49	JWH133	CB2	MESH:C432747	12802(Tax:10090)	Chemical	Gene	agonist|appos|START_ENTITY agonist|nummod|END_ENTITY	Influence of nicotinic receptor modulators on CB2 cannabinoid receptor agonist -LRB- JWH133 -RRB- - induced antinociception in mice .
16847144	0	JX401	0,5	p38alpha	9,17	JX401	p38alpha	null	1432	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	JX401 , A p38alpha inhibitor containing a 4-benzylpiperidine motif , identified via a novel screening system in yeast .
26530088	0	Jasmonate	73,82	JAZ3	41,45	Jasmonate	JAZ3	MESH:C011006	821055(Tax:3702)	Chemical	Gene	Responses|nmod|START_ENTITY Responses|compound|END_ENTITY	FILAMENTOUS_FLOWER Is a Direct Target of JAZ3 and Modulates Responses to Jasmonate .
26986569	0	Javamide-II	82,93	Sirt1/2	120,127	Javamide-II	Sirt1/2	null	22933	Chemical	Gene	START_ENTITY|nmod|Inhibitor Inhibitor|compound|END_ENTITY	Finding Potent Sirt Inhibitor in Coffee : Isolation , Confirmation and Synthesis of Javamide-II -LRB- N-Caffeoyltryptophan -RRB- as Sirt1/2 Inhibitor .
11160900	0	Juglone	0,7	Pin1	55,59	Juglone	Pin1	MESH:C005134	5300	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Juglone , an inhibitor of the peptidyl-prolyl isomerase Pin1 , also directly blocks transcription .
26039047	0	Juglone	15,22	Pin1	0,4	Juglone	Pin1	MESH:C005134	5300	Chemical	Gene	Effects|compound|START_ENTITY Effects|compound|END_ENTITY	Pin1 Inhibitor Juglone Exerts Anti-Oncogenic Effects on LNCaP and DU145 Cells despite the Patterns of Gene Regulation by Pin1 Differing between These Cell Lines .
26039047	0	Juglone	15,22	Pin1	121,125	Juglone	Pin1	MESH:C005134	5300	Chemical	Gene	Effects|compound|START_ENTITY Cells|nsubj|Effects Cells|nmod|Differing Differing|compound|END_ENTITY	Pin1 Inhibitor Juglone Exerts Anti-Oncogenic Effects on LNCaP and DU145 Cells despite the Patterns of Gene Regulation by Pin1 Differing between These Cell Lines .
16021692	0	Juliflorine	0,11	acetylcholinesterase	75,95	Juliflorine	acetylcholinesterase	MESH:C048175	43	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	Juliflorine : a potent natural peripheral anionic-site-binding inhibitor of acetylcholinesterase with calcium-channel blocking potential , a leading candidate for Alzheimer 's _ disease therapy .
17855771	0	Juxtacrine	0,10	EGFR	25,29	Juxtacrine	EGFR	null	404306(Tax:9615)	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Juxtacrine activation of EGFR regulates claudin expression and increases transepithelial resistance .
20195385	7	K	1336,1337	ATP	1338,1341	K	Sur	null	34350(Tax:7227)	Chemical	Gene	channels|compound|START_ENTITY channels|appos|END_ENTITY	The presence of functional K -LRB- ATP -RRB- channels in adult IPCs is further substantiated by in situ hybridization detecting the transcript for the sulfonylurea_receptor -LRB- Sur -RRB- subunit of the K -LRB- ATP -RRB- channel in those cells .
20450563	6	K	950,951	ATP	952,955	K	SBP	null	25540(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	The current densities of K -LRB- ATP -RRB- channel between F4 and T4 group , F12 and T12 group were compared under 0 mV of test potential .
21162257	0	K	40,41	CA1	66,69	K	CA1	null	759	Chemical	Gene	channels|compound|START_ENTITY channels|nmod|END_ENTITY	-LSB- Protection mechanisms of ATP-sensitive K channels on hippocampal CA1 neurons during chronic severe hypoxia -RSB- .
19059420	0	K	31,32	CA3	27,30	K	CA3	null	12350(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Involvement of hippocampal CA3 K -LRB- ATP -RRB- channels in contextual memory .
16891388	0	K	44,45	CFTR	23,27	K	CFTR	null	1080	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of ENaC and CFTR expression with K + channel modulators and effect on fluid absorption across alveolar epithelial cells .
19481058	0	K	52,53	Caveolin-3	0,10	K	Caveolin-3	null	859	Chemical	Gene	channels|compound|START_ENTITY regulates|dobj|channels regulates|nsubj|END_ENTITY	Caveolin-3 negatively regulates recombinant cardiac K -LRB- ATP -RRB- channels .
15604124	0	K	92,93	EP3	112,115	K	EP3	null	24929(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|nmod|receptor receptor|compound|END_ENTITY	Prostacyclin attenuates oxidative damage of myocytes by opening mitochondrial ATP-sensitive K + channels via the EP3 receptor .
18671941	0	K	51,52	Insulin-like_growth_factor-I	0,28	K	Insulin-like growth factor-I	null	24482(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY inhibits|dobj|channels inhibits|nsubj|END_ENTITY	Insulin-like_growth_factor-I inhibits rat arterial K -LRB- ATP -RRB- channels through pI 3-kinase .
23626843	0	K	34,35	KCNJ11	50,56	K	KCNJ11	null	3767	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Gain-of-function mutations in the K -LRB- ATP -RRB- channel -LRB- KCNJ11 -RRB- impair coordinated hand-eye tracking .
10903994	0	K	38,39	NDP	40,43	K	NDP	null	363443(Tax:10116)	Chemical	Gene	subtype|compound|START_ENTITY subtype|appos|END_ENTITY	Inhibition by protein_kinase_C of the K -LRB- NDP -RRB- subtype of vascular smooth muscle ATP-sensitive potassium channel .
24944475	0	K	19,20	NKCC1	46,51	K	NKCC1	D011188	6558	Chemical	Gene	Role|nmod|START_ENTITY Role|dep|END_ENTITY	Role of the Na / K / 2Cl cotransporter NKCC1 in cell cycle progression in human esophageal_squamous_cell_carcinoma .
15684589	0	K	72,73	Prolactin	0,9	K	Prolactin	null	5617	Chemical	Gene	channels|compound|START_ENTITY inhibits|dobj|channels inhibits|nsubj|END_ENTITY	Prolactin , an activator of epithelial Na + channel , inhibits basolateral K + channels in adult tree frog skin .
12359308	0	K	31,32	Protein_kinase_G	0,16	K	Protein kinase G	null	5592	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Protein_kinase_G activation of K -LRB- ATP -RRB- channels in human-cultured prostatic_stromal cells .
12122112	0	K	83,84	Sur2	78,82	K	Sur2	null	20928(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Episodic coronary_artery_vasospasm and hypertension develop in the absence of Sur2 K -LRB- ATP -RRB- channels .
12163544	0	K	37,38	TGFbeta1	55,63	K	TGFbeta1	null	100873157	Chemical	Gene	channels|compound|START_ENTITY channels|nmod|END_ENTITY	Developmental regulation of neuronal K -LRB- Ca -RRB- channels by TGFbeta1 : an essential role for PI3 kinase signaling and membrane insertion .
20332621	0	K	35,36	caveolin-3	54,64	K	caveolin-3	null	29161(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|nmod|END_ENTITY	Role for SUR2A in coupling cardiac K -LRB- ATP -RRB- channels to caveolin-3 .
11945020	0	K	125,126	iNOS	102,106	K	iNOS	null	18126(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Late preconditioning elicited by activation of adenosine_A -LRB- 3 -RRB- _ receptor in heart : role of NF - _ kappa_B , iNOS and mitochondrial K -LRB- ATP -RRB- channel .
21602835	0	K	25,26	insulin	71,78	K	insulin	null	3630	Chemical	Gene	channels|compound|START_ENTITY understanding|nmod|channels understanding|dep|focus focus|nmod|disorders disorders|compound|END_ENTITY	Current understanding of K ATP channels in neonatal_diseases : focus on insulin secretion disorders .
11600677	0	K	85,86	protein_kinase_A	104,120	K	protein kinase A	null	25636(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|nmod|END_ENTITY	Evidence for involvement of A-kinase anchoring protein in activation of rat arterial K -LRB- ATP -RRB- channels by protein_kinase_A .
15328158	0	K-11706	23,30	GATA	40,44	K-11706	GATA	null	76563(Tax:10090)	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Oral administration of K-11706 inhibits GATA binding activity , enhances hypoxia-inducible_factor_1 binding activity , and restores indicators in an in vivo mouse model of anemia_of_chronic_disease .
22659587	0	K-134	0,5	phosphodiesterase_3	9,28	K-134	phosphodiesterase 3	null	498900(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	K-134 , a phosphodiesterase_3 inhibitor , improves gait disturbance and hindlimb blood flow_impairment in rat peripheral artery_disease models .
23110051	0	K-134	0,5	phosphodiesterase_3	9,28	K-134	phosphodiesterase 3	null	498900(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	K-134 , a phosphodiesterase_3 inhibitor , prevents brain_damage by inhibiting thrombus formation in a rat cerebral_infarction model .
26015437	0	K-312	19,24	CETP	4,8	K-312	CETP	null	1071	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	New CETP Inhibitor K-312 Reduces PCSK9 Expression : A Potential Effect on LDL Cholesterol Metabolism .
26015437	0	K-312	19,24	PCSK9	33,38	K-312	PCSK9	null	255738	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	New CETP Inhibitor K-312 Reduces PCSK9 Expression : A Potential Effect on LDL Cholesterol Metabolism .
16820149	0	K-604	30,35	ACAT-1	12,18	K-604	ACAT-1	MESH:C520671	38	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	A selective ACAT-1 inhibitor , K-604 , suppresses fatty_streak_lesions in fat-fed hamsters without affecting plasma cholesterol levels .
20843517	0	K-604	30,35	ACAT-1	12,18	K-604	ACAT-1	MESH:C520671	110446(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	A selective ACAT-1 inhibitor , K-604 , stimulates collagen production in cultured smooth muscle cells and alters plaque phenotype in apolipoprotein_E-knockout mice .
24162023	0	K-685	0,5	TRPV1	9,14	K-685	TRPV1	null	83810(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	K-685 , a TRPV1 antagonist , blocks PKC-sensitized TRPV1 activation and improves the inflammatory_pain in a rat complete Freund 's adjuvant model .
10942735	0	K-Cl	19,23	KCC2	14,18	K-Cl	KCC2	CHEBI:32588	57468	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Dependence of KCC2 K-Cl cotransporter activity on a conserved carboxy terminus tyrosine residue .
10600773	0	K-Cl	65,69	KCC3	53,57	K-Cl	KCC3	CHEBI:32588	9990	Chemical	Gene	cotransporter|amod|START_ENTITY END_ENTITY|appos|cotransporter	Molecular cloning and functional characterization of KCC3 , a new K-Cl cotransporter .
14748409	0	K027	62,66	acetylcholinesterase	25,45	K027	acetylcholinesterase	null	43	Chemical	Gene	using|dobj|START_ENTITY END_ENTITY|acl|using	In vitro reactivation of acetylcholinesterase using the oxime K027 .
19713720	0	K327	59,63	CCR4	67,71	K327	CCR4	null	12773(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|cell cell|compound|END_ENTITY	Inhibitory effect of the new orally active CCR4 antagonist K327 on CCR4 + CD4 + T cell migration into the lung of mice with ovalbumin-induced lung_allergic_inflammation .
10213168	0	KA-672	0,6	acetylcholinesterase	26,46	KA-672	acetylcholinesterase	MESH:C112452	83817(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	KA-672 inhibits rat brain acetylcholinesterase in vitro but not in vivo .
9586571	0	KAA-276	90,97	histamine_H1_receptor	56,77	KAA-276	histamine H1 receptor	MESH:C112798	100135539(Tax:10141)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Pharmacological characterization of a novel long-acting histamine_H1_receptor antagonist , KAA-276 .
7566499	0	KAE-393	85,92	5-HT3_receptor	43,57	KAE-393	5-HT3 receptor	MESH:C085986	79246(Tax:10116)	Chemical	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Comparative study of the affinities of the 5-HT3_receptor antagonists , YM060 , YM114 -LRB- KAE-393 -RRB- , granisetron and ondansetron in rat vagus nerve and cerebral cortex .
849647	0	KAF	38,41	C3b	23,26	KAF	C3b	null	100862689	Chemical	Gene	deficiency|appos|START_ENTITY deficiency|compound|END_ENTITY	A second case of human C3b inhibitor -LRB- KAF -RRB- deficiency .
19174156	0	KB-34	0,5	activator_protein-1	183,202	KB-34	activator protein-1	null	3727	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|nmod|END_ENTITY	KB-34 , a newly synthesized chalcone derivative , inhibits lipopolysaccharide-stimulated nitric_oxide production in RAW 264.7 macrophages via heme_oxygenase-1 induction and blockade of activator_protein-1 .
10480662	0	KB-R6933	72,80	5-HT3_receptor	90,104	KB-R6933	5-HT3 receptor	MESH:C121292	79246(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Improvement of cisplatin-induced emesis and delayed gastric_emptying by KB-R6933 , a novel 5-HT3_receptor antagonist .
20096662	0	KB-R7943	0,8	ICAM-1	51,57	KB-R7943	ICAM-1	MESH:C101670	3383	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	KB-R7943 inhibits high glucose-induced endothelial ICAM-1 expression and monocyte-endothelial adhesion .
19445901	0	KBH-A42	58,65	histone_deacetylase	27,46	KBH-A42	histone deacetylase	MESH:C534553	9734	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	A novel delta-lactam-based histone_deacetylase inhibitor , KBH-A42 , induces cell cycle arrest and apoptosis in colon_cancer cells .
17099729	0	KCC009	30,36	Transglutaminase_2	0,18	KCC009	Transglutaminase 2	MESH:C510621	7052	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Transglutaminase_2 inhibitor , KCC009 , disrupts fibronectin assembly in the extracellular matrix and sensitizes orthotopic_glioblastomas to chemotherapy .
14527827	0	KCH-1110	82,90	dopamine_D3_receptor	49,69	KCH-1110	dopamine D3 receptor	MESH:C488454	13490(Tax:10090)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Pharmacological actions of a novel and selective dopamine_D3_receptor antagonist , KCH-1110 .
25580149	0	KCHO-1	0,6	Heme_Oxygenase-1	131,147	KCHO-1	Heme Oxygenase-1	null	3162	Chemical	Gene	Inhibits|nsubj|START_ENTITY Inhibits|nmod|Expression Expression|compound|END_ENTITY	KCHO-1 , a Novel Antineuroinflammatory Agent , Inhibits Lipopolysaccharide-Induced Neuroinflammatory Responses through Nrf2-Mediated Heme_Oxygenase-1 Expression in Mouse BV2 Microglia Cells .
15274670	0	KC_11458	30,38	motilin	14,21	KC 11458	motilin	MESH:C493967	4295	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|agonist agonist|compound|END_ENTITY	Effect of the motilin agonist KC_11458 on gastric emptying in diabetic_gastroparesis .
15030385	0	KCl	0,3	cholecystokinin	46,61	KCl	cholecystokinin	CHEBI:32588	885	Chemical	Gene	up-regulate|nsubj|START_ENTITY up-regulate|dobj|expression expression|compound|END_ENTITY	KCl and forskolin synergistically up-regulate cholecystokinin gene expression via coordinate activation of CREB and the co-activator CBP .
2069772	0	KCl	18,21	renin	59,64	KCl	renin	CHEBI:32588	5972	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|compound|END_ENTITY	Chronic effect of KCl on black-white differences in plasma renin activity , aldosterone , and urinary electrolytes .
11928723	0	KD3-671	26,33	angiotensin_II_type_1_receptor	38,68	KD3-671	angiotensin II type 1 receptor	MESH:C121117	81638(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|antagonist antagonist|amod|END_ENTITY	Antiproteinuric effect of KD3-671 , an angiotensin_II_type_1_receptor antagonist , in rats with accelerated passive Heymann_nephritis .
12808291	0	KD3-671	11,18	angiotensin_II_type_1_receptor	23,53	KD3-671	angiotensin II type 1 receptor	MESH:C121117	81638(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Effects of KD3-671 , an angiotensin_II_type_1_receptor antagonist , on anti-thy-1 nephritis in rats .
18483295	0	KD5170	0,6	histone_deacetylase	37,56	KD5170	histone deacetylase	MESH:C530801	9734	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	KD5170 , a novel mercaptoketone-based histone_deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo .
12635495	0	KE-758	0,6	THP-1	147,152	KE-758	THP-1	MESH:C102509	2736	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	KE-758 , an active metabolite of the new anti-rheumatic drug KE-298 , suppresses production of tumor_necrosis_factor-alpha and interleukin-1_beta in THP-1 , a human monocyte cell line .
11841839	0	KE-758	71,77	thioredoxin	94,105	KE-758	thioredoxin	MESH:C102509	7295	Chemical	Gene	START_ENTITY|nmod|secretion secretion|nmod|END_ENTITY	Effects of a new anti-rheumatic drug KE-298 and its active metabolite : KE-758 on secretion of thioredoxin and on the level of intracellular glutathione in human monocytes and T cells .
12479017	0	KF-950	29,35	acrosin	39,46	KF-950	acrosin	null	49	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	-LSB- Effect of acrosin inhibitor KF-950 on acrosin activity and acrosome of human sperm -RSB- .
8045270	0	KF17837	0,7	adenosine_A2A_receptor	27,49	KF17837	adenosine A2A receptor	MESH:C081198	135	Chemical	Gene	START_ENTITY|dep|antagonist antagonist|amod|END_ENTITY	KF17837 : a novel selective adenosine_A2A_receptor antagonist with anticataleptic activity .
8121082	0	KF18259	30,37	5-HT3-receptor	47,61	KF18259	5-HT3-receptor	MESH:C086124	79246(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Pharmacological properties of KF18259 , a novel 5-HT3-receptor antagonist , in rats : inhibition of the distal colonic function .
15021978	0	KF19514	0,7	GM-CSF	75,81	KF19514	GM-CSF	MESH:C106878	1437	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	KF19514 , a phosphodiesterase 4 and 1 inhibitor , inhibits TNF-alpha-induced GM-CSF production by a human bronchial epithelial cell line via inhibition of PDE4 .
11752117	0	KF24345	0,7	tumor_necrosis_factor-alpha	78,105	KF24345	tumor necrosis factor-alpha	MESH:C444645	21926(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|production production|amod|END_ENTITY	KF24345 , an adenosine uptake inhibitor , suppresses lipopolysaccharide-induced tumor_necrosis_factor-alpha production and leukopenia via endogenous adenosine in mice .
3934441	0	KF4939	0,6	phospholipase_C	58,73	KF4939	phospholipase C	MESH:C037861	100009319(Tax:9986)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	KF4939 , a new anti-platelet agent , inhibits activation of phospholipase_C and A2 in rabbit platelets .
3093434	2	KF8940	40,46	5-lipoxygenase	124,138	KF8940	5-lipoxygenase	MESH:C001333	25290(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	KF8940 -LRB- 2-n-heptyl-4-hydroxyquinoline-N-oxide -RRB- , a potent and selective inhibitor of 5-lipoxygenase , produced by Pseudomonas_methanica .
12696182	0	KFA-1411	44,52	factor_Xa	82,91	KFA-1411	factor Xa	MESH:C487858	2159	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Characteristics of the hemostatic action of KFA-1411 , an inhibitor of coagulation factor_Xa -LRB- FXa -RRB- , in humans and various animals .
17404068	0	KG-135	0,6	COX-2	16,21	KG-135	COX-2	null	5743	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	KG-135 inhibits COX-2 expression by blocking the activation of JNK and AP-1 in phorbol_ester-stimulated human breast epithelial cells .
23748470	0	KGP94	45,50	Cathepsin_L	0,11	KGP94	Cathepsin L	MESH:C581086	1514	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Cathepsin_L inhibition by the small molecule KGP94 suppresses tumor microenvironment enhanced metastasis associated cell functions of prostate and breast_cancer cells .
23168380	0	KGP94	49,54	cathepsin_L	117,128	KGP94	cathepsin L	MESH:C581086	1514	Chemical	Gene	activity|nmod|START_ENTITY evaluation|nmod|activity evaluation|appos|inhibitor inhibitor|nmod|END_ENTITY	Initial evaluation of the antitumour activity of KGP94 , a functionalized benzophenone_thiosemicarbazone inhibitor of cathepsin_L .
11477664	0	KIAA0128	53,61	Septin_6	44,52	KIAA0128	Septin 6	null	23157	Chemical	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	An ins -LRB- X ; 11 -RRB- -LRB- q24 ; q23 -RRB- fuses the MLL and the Septin_6 / KIAA0128 gene in an infant with AML-M2 .
19666101	0	KIOM-79	0,7	TGF-beta1	31,40	KIOM-79	TGF-beta1	MESH:C517978	21803(Tax:10090)	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|dobj|END_ENTITY	KIOM-79 prevents S100b-induced TGF-beta1 and fibronectin expression in mouse mesangial cells .
16806764	0	KIOM-79	0,7	iNOS	29,33	KIOM-79	iNOS	MESH:C517978	18126(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	KIOM-79 inhibits LPS-induced iNOS gene expression by blocking NF-kappaB/Rel and p38 kinase activation in murine macrophages .
23748899	0	KIST101029	66,76	activator_protein-1	81,100	KIST101029	activator protein-1	null	16476(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Inhibitory effects of a new 1H-pyrrolo -LSB- 3,2-c -RSB- pyridine derivative , KIST101029 , on activator_protein-1 activity and neoplastic cell transformation induced by insulin-like_growth_factor-1 .
22875710	7	KM-233	928,934	GBM	913,916	KM-233	MEK	MESH:C512823	5609	Chemical	Gene	cells|nmod|START_ENTITY cells|compound|END_ENTITY	Treatment of U87MG human GBM cells with KM-233 caused a time dependent change in the phosphorylation profiles of MEK , ERK1/2 , Akt , BAD , STAT3 , and p70S6K .
11260350	0	KMD-3213	10,18	alpha1A-adrenoceptor	23,43	KMD-3213	alpha1A-adrenoceptor	MESH:C095285	403866(Tax:9615)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Effect of KMD-3213 , an alpha1A-adrenoceptor antagonist , on the prostatic urethral pressure and blood pressure in male decerebrate dogs .
9274928	0	KMD-3213	0,8	alpha1A-adrenoceptor	18,38	KMD-3213	alpha1A-adrenoceptor	MESH:C095285	148	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	KMD-3213 , a novel alpha1A-adrenoceptor antagonist , potently inhibits the functional alpha1-adrenoceptor in human prostate .
12419883	0	KMD-3213	11,19	alpha_1A-adrenoceptor	36,57	KMD-3213	alpha 1A-adrenoceptor	MESH:C095285	29412(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Effects of KMD-3213 , a uroselective alpha_1A-adrenoceptor antagonist , on the tilt-induced blood pressure response in normotensive rats .
14643307	0	KMI-008	0,7	beta-secretase	17,31	KMI-008	beta-secretase	MESH:C488219	23621	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	KMI-008 , a novel beta-secretase inhibitor containing a hydroxymethylcarbonyl isostere as a transition-state mimic : design and synthesis of substrate-based octapeptides .
25702135	0	KMS04014	58,66	NQO1	13,17	KMS04014	NQO1	null	18104(Tax:10090)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of NQO1 and Neuroprotection by a Novel Compound KMS04014 in Parkinson 's _ Disease Models .
21165333	0	KN-62	17,22	CaMKII	0,6	KN-62	CaMKII	MESH:C063302	818	Chemical	Gene	Tumor|compound|START_ENTITY Tumor|compound|END_ENTITY	CaMKII Inhibitor KN-62 Blunts Tumor Response to Hypoxia by Inhibiting HIF-1a in Hepatoma Cells .
7733984	0	KN-62	78,83	angiotensin_II	14,28	KN-62	angiotensin II	MESH:C063302	183	Chemical	Gene	secretion|nmod|START_ENTITY secretion|amod|END_ENTITY	Inhibition of angiotensin_II - and potassium-mediated aldosterone secretion by KN-62 suggests involvement of Ca -LRB- 2 + -RRB- - calmodulin dependent protein kinase II in aldosterone secretion .
8519682	0	KN-93	67,72	CaMK-II	90,97	KN-93	CaMK-II	MESH:C072105	12325(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	G1 cell cycle arrest and apoptosis are induced in NIH 3T3 cells by KN-93 , an inhibitor of CaMK-II -LRB- the multifunctional Ca2 + / CaM kinase -RRB- .
17457979	0	KN-93	0,5	CaMKII	31,37	KN-93	CaMKII	MESH:C072105	818	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	KN-93 , a specific inhibitor of CaMKII inhibits human hepatic stellate cell proliferation in vitro .
10341733	0	KN-93	38,43	calmodulin-dependent_protein_kinase_II	61,99	KN-93	calmodulin-dependent protein kinase II	MESH:C072105	108058(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|inhibitor inhibitor|nmod|END_ENTITY	Biochemical and biological effects of KN-93 , an inhibitor of calmodulin-dependent_protein_kinase_II , on the initial events of mouse egg activation induced by ethanol .
10762053	0	KN62	55,59	P2X7-receptor	88,101	KN62	P2X7-receptor	MESH:C063302	5027	Chemical	Gene	Synthesis|nmod|START_ENTITY Synthesis|nmod|END_ENTITY	Synthesis of conformationally constrained analogues of KN62 , a potent antagonist of the P2X7-receptor .
12040970	0	KN62	153,157	P2X7-receptor	186,199	KN62	P2X7-receptor	MESH:C063302	5027	Chemical	Gene	activity|nmod|START_ENTITY activity|nmod|END_ENTITY	Synthesis , biological activity and molecular modeling studies of 1,2,3,4-tetrahydroisoquinoline derivatives as conformationally constrained analogues of KN62 , a potent antagonist of the P2X7-receptor containing a tyrosine moiety .
18957419	5	KN93	1285,1289	CamKII	1266,1272	KN93	CamKII	MESH:C072105	818	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|appos|END_ENTITY	Further downstream , the Ca2 + / calmodulin-dependent_protein_kinase_II -LRB- CamKII -RRB- inhibitor , KN93 , inhibited betaAR - and Epac-mediated CICR in PLCepsilon + / + but not PLCepsilon - / - myocytes .
17681842	0	KNK437	15,21	heat_shock_protein	79,97	KNK437	heat shock protein	MESH:C410027	398343(Tax:8355)	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|expression expression|compound|END_ENTITY	Examination of KNK437 - and quercetin-mediated inhibition of heat_shock-induced heat_shock_protein gene expression in Xenopus_laevis cultured cells .
20111068	0	KOS-1022	67,75	heat_shock_protein_90	21,42	KOS-1022	heat shock protein 90	MESH:C448659	3320	Chemical	Gene	alvespimycin|appos|START_ENTITY alvespimycin|amod|END_ENTITY	Phase I study of the heat_shock_protein_90 inhibitor alvespimycin -LRB- KOS-1022 , 17-DMAG -RRB- administered intravenously twice weekly to patients with acute_myeloid_leukemia .
8804723	0	KP-102	37,43	c-fos	52,57	KP-102	c-fos	MESH:C091874	314322(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	The growth hormone-releasing peptide KP-102 induces c-fos expression in the arcuate nucleus .
24797784	0	KP1019	17,23	Hog1	32,36	KP1019	Hog1	MESH:C499292	850803(Tax:4932)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|amod|END_ENTITY	Anti-cancer drug KP1019 induces Hog1 phosphorylation and protein ubiquitylation in Saccharomyces_cerevisiae .
10081661	0	KP102	68,73	growth_hormone	35,49	KP102	growth hormone	MESH:C091874	102171600	Chemical	Gene	release|nummod|START_ENTITY secretagogue|dobj|release secretagogue|nsubj|administration administration|nmod|END_ENTITY	Oral administration of peptidergic growth_hormone -LRB- GH -RRB- secretagogue KP102 stimulates GH release in goats .
11164332	0	KP102	93,98	growth_hormone	7,21	KP102	growth hormone	MESH:C091874	102171600	Chemical	Gene	administration|nmod|START_ENTITY END_ENTITY|nmod|administration	Plasma growth_hormone -LRB- GH -RRB- responses after administration of the peptidergic GH secretagogue KP102 into the oral cavity , rumen , abomasum and duodenum in adult goats .
15870708	0	KP372-1	18,25	Akt	37,40	KP372-1	Akt	MESH:C501199	207	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|activity activity|compound|END_ENTITY	The Akt inhibitor KP372-1 suppresses Akt activity and cell proliferation and induces apoptosis in thyroid_cancer cells .
26620414	0	KPT-330	0,7	XPO-1	44,49	KPT-330	XPO-1	MESH:C585161	103573(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|appos|END_ENTITY	KPT-330 , a potent and selective exportin-1 -LRB- XPO-1 -RRB- inhibitor , shows antitumor effects modulating the expression of cyclin_D1 and surviving in prostate_cancer models .
26753765	0	KPT-330	12,19	XPO-1	56,61	KPT-330	XPO-1	MESH:C585161	7514	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|appos|END_ENTITY	Erratum to : KPT-330 , a potent and selective exportin-1 -LRB- XPO-1 -RRB- inhibitor , shows antitumor effects modulating the expression of cyclin_D1 and survivin in prostate_cancer models .
26753765	0	KPT-330	12,19	exportin-1	44,54	KPT-330	exportin-1	MESH:C585161	7514	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Erratum to : KPT-330 , a potent and selective exportin-1 -LRB- XPO-1 -RRB- inhibitor , shows antitumor effects modulating the expression of cyclin_D1 and survivin in prostate_cancer models .
20132813	0	KR-003048	0,9	p38_mitogen-activated_protein_kinase	48,84	KR-003048	p38 mitogen-activated protein kinase	MESH:C550450	1432	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	KR-003048 , a potent , orally active inhibitor of p38_mitogen-activated_protein_kinase .
16106524	0	KR-62436	0,8	DPP-IV	132,138	KR-62436	DPP-IV	MESH:C503941	13482(Tax:10090)	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|appos|END_ENTITY	KR-62436 , 6 - -LCB- 2 - -LSB- 2 - -LRB- 5-cyano-4 ,5 - dihydropyrazol-1-yl -RRB- -2 - oxoethylamino -RSB- ethylamino -RCB- nicotinonitrile , is a novel dipeptidyl_peptidase-IV -LRB- DPP-IV -RRB- inhibitor with anti-hyperglycemic activity .
16106524	0	KR-62436	0,8	dipeptidyl_peptidase-IV	107,130	KR-62436	dipeptidyl peptidase-IV	MESH:C503941	13482(Tax:10090)	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|amod|END_ENTITY	KR-62436 , 6 - -LCB- 2 - -LSB- 2 - -LRB- 5-cyano-4 ,5 - dihydropyrazol-1-yl -RRB- -2 - oxoethylamino -RSB- ethylamino -RCB- nicotinonitrile , is a novel dipeptidyl_peptidase-IV -LRB- DPP-IV -RRB- inhibitor with anti-hyperglycemic activity .
19347570	0	KR-62776	28,36	PPAR_gamma	0,10	KR-62776	PPAR gamma	MESH:C534486	19016(Tax:10090)	Chemical	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	PPAR_gamma partial agonist , KR-62776 , inhibits adipocyte differentiation via activation of ERK .
16797489	0	KR-62980	0,8	peroxisome_proliferator-activated_receptor_gamma	18,66	KR-62980	peroxisome proliferator-activated receptor gamma	MESH:C513115	19016(Tax:10090)	Chemical	Gene	START_ENTITY|dep|agonist agonist|amod|END_ENTITY	KR-62980 : a novel peroxisome_proliferator-activated_receptor_gamma agonist with weak adipogenic effects .
14757158	0	KR61639	64,71	protein_tyrosine_phosphatase-1B	21,52	KR61639	protein tyrosine phosphatase-1B	MESH:C491551	5770	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Discovery of a novel protein_tyrosine_phosphatase-1B inhibitor , KR61639 : potential development as an antihyperglycemic agent .
25912878	0	KRC-108	11,18	Aurora_A	26,34	KRC-108	Aurora A	MESH:C572621	6790	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|compound|END_ENTITY	Effects of KRC-108 on the Aurora_A activity and growth of colorectal_cancer cells .
23348694	0	KRC-408	0,7	c-Met	17,22	KRC-408	c-Met	MESH:C580772	4233	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	KRC-408 , a novel c-Met inhibitor , suppresses cell proliferation and angiogenesis of gastric_cancer .
22772800	0	KRH-3955	58,66	CXCR4	40,45	KRH-3955	CXCR4	MESH:C541387	102142487	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	Single oral administration of the novel CXCR4 antagonist , KRH-3955 , induces an efficient and long-lasting increase of white blood cell count in normal macaques , and prevents CD4 depletion in SHIV-infected macaques : a preliminary study .
2666609	0	KRI-1314	77,85	renin	17,22	KRI-1314	renin	MESH:C060500	5972	Chemical	Gene	dipeptide|appos|START_ENTITY inhibitor|dep|dipeptide inhibitor|compound|END_ENTITY	An orally active renin inhibitor : cyclohexylnorstatine-containing dipeptide -LRB- KRI-1314 -RRB- .
8175079	0	KRI-1314	45,53	renin	29,34	KRI-1314	renin	MESH:C060500	5972	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|action action|nmod|END_ENTITY	-LSB- Hypotensive action of human renin inhibitor KRI-1314 in the common_marmoset -RSB- .
8271523	0	KRI-1314	0,8	renin	49,54	KRI-1314	renin	MESH:C060500	5972	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	KRI-1314 : an orally effective inhibitor of human renin .
21078672	0	KRIBB11	0,7	HSP70	17,22	KRIBB11	HSP70	MESH:C556094	3308	Chemical	Gene	synthesis|compound|START_ENTITY synthesis|compound|END_ENTITY	KRIBB11 inhibits HSP70 synthesis through inhibition of heat_shock factor 1 function by impairing the recruitment of positive transcription elongation factor b to the hsp70 promoter .
10761713	0	KRN5500	26,33	P-glycoprotein	86,100	KRN5500	P-glycoprotein	MESH:C092296	5243	Chemical	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The novel anticancer drug KRN5500 interacts with , but is hardly transported by , human P-glycoprotein .
15634658	0	KRN633	0,6	vascular_endothelial_growth_factor	33,67	KRN633	vascular endothelial growth factor	MESH:C508488	7422	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|kinase kinase|amod|END_ENTITY	KRN633 : A selective inhibitor of vascular_endothelial_growth_factor receptor-2 tyrosine kinase that suppresses tumor angiogenesis and growth .
23780833	0	KRN633	0,6	vascular_endothelial_growth_factor	24,58	KRN633	vascular endothelial growth factor	MESH:C508488	22339(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|kinase kinase|compound|END_ENTITY	KRN633 , an inhibitor of vascular_endothelial_growth_factor receptor tyrosine kinase , induces intrauterine_growth_restriction in mice .
10421076	0	KRN8602	20,27	MX2	28,31	KRN8602	MX2	MESH:C053537	4600	Chemical	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	A phase II study of KRN8602 -LRB- MX2 -RRB- , a novel morpholino anthracycline derivative , in patients with recurrent malignant_glioma .
11083079	0	KRN8602	34,41	MX2	43,46	KRN8602	MX2	MESH:C053537	4600	Chemical	Gene	trial|nmod|START_ENTITY trial|appos|END_ENTITY	Phase II trial of pre-irradiation KRN8602 -LRB- MX2 -RRB- in malignant_glioma patients .
9644314	0	KRN8602	19,26	MX2	28,31	KRN8602	MX2	MESH:C053537	4600	Chemical	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	-LSB- Phase II study of KRN8602 -LRB- MX2 -RRB- for malignant_lymphoma -RSB- .
9987504	0	KRN8602	30,37	MX2	39,42	KRN8602	MX2	MESH:C053537	4600	Chemical	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	-LSB- Pilot late phase II study of KRN8602 -LRB- MX2 -RRB- , a novel anthracycline derivative , for acute_leukemia -- a dose finding study in combination -RSB- .
16982756	0	KRN951	0,6	vascular_endothelial_growth_factor	37,71	KRN951	vascular endothelial growth factor	MESH:C553176	7422	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|kinases kinases|compound|END_ENTITY	KRN951 , a highly potent inhibitor of vascular_endothelial_growth_factor receptor tyrosine kinases , has antitumor activities and affects functional vascular properties .
15151518	0	KRN_1493	23,31	parathyroid_hormone	46,65	KRN 1493	parathyroid hormone	MESH:C476217	5741	Chemical	Gene	lowers|nsubj|START_ENTITY lowers|dobj|END_ENTITY	The calcimimetic agent KRN_1493 lowers plasma parathyroid_hormone and ionized calcium concentrations in patients with chronic_renal_failure on haemodialysis both on the day of haemodialysis and on the day without haemodialysis .
8690301	0	KSG-504	11,18	CCK-A-receptor	26,40	KSG-504	CCK-A-receptor	MESH:C085253	24889(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	-LSB- Effect of KSG-504 , a new CCK-A-receptor antagonist , on experimental acute pancreatitis in rats and mice -RSB- .
8720295	0	KSG-504	23,30	CCK-A_receptor	38,52	KSG-504	CCK-A receptor	MESH:C085253	488846(Tax:9615)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	-LSB- Behavioral studies of KSG-504 , a new CCK-A_receptor antagonist -RSB- .
8720296	0	KSG-504	12,19	CCK-A_receptor	27,41	KSG-504	CCK-A receptor	MESH:C085253	24889(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	-LSB- Effects of KSG-504 , a new CCK-A_receptor antagonist , on gallbladder and gastrointestinal functions -RSB- .
7506805	0	KSG-504	27,34	cholecystokinin-A-receptor	42,68	KSG-504	cholecystokinin-A-receptor	MESH:C085253	24889(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Pharmacological profile of KSG-504 , a new cholecystokinin-A-receptor antagonist .
8866756	0	KSG-504	11,18	cholecystokinin-A-receptor	26,52	KSG-504	cholecystokinin-A-receptor	MESH:C085253	24889(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Effects of KSG-504 , a new cholecystokinin-A-receptor antagonist , on pancreatic exocrine and endocrine secretions in rats .
2325635	0	KT5926	0,6	myosin_light_chain_kinase	44,69	KT5926	myosin light chain kinase	MESH:C063769	100009143(Tax:9986)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	KT5926 , a potent and selective inhibitor of myosin_light_chain_kinase .
20722489	0	KTO-7924	0,8	Beta3-adrenergic_receptor	12,37	KTO-7924	Beta3-adrenergic receptor	null	11556(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	KTO-7924 , a Beta3-adrenergic_receptor agonist , reduces hyperglycemia , and protects beta-cells in the islets of langerhans of db/db mice .
22576130	0	KU-0060648	38,48	DNA-PK	70,76	KU-0060648	DNA-PK	MESH:C576809	5591	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Chemosensitization of cancer cells by KU-0060648 , a dual inhibitor of DNA-PK and PI-3K .
26933997	3	KU-0060648	549,559	DNA-PKcs	447,455	KU-0060648	DNA-PKcs	MESH:C576809	5591	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	DNA-PKcs -LRB- DNA-activated_protein_kinase_catalytic_subunit -RRB- is an important but not exclusive target of KU-0060648 .
25939977	0	KU675	0,5	Hsp90	53,58	KU675	Hsp90	null	3320	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|nmod|END_ENTITY	KU675 , a Concomitant Heat-Shock Protein Inhibitor of Hsp90 and Hsc70 that Manifests Isoform Selectivity for Hsp90a in Prostate_Cancer Cells .
14696094	0	KW-2189	45,52	hnRNP_L	0,7	KW-2189	hnRNP L	MESH:C086920	3191	Chemical	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	hnRNP_L enhances sensitivity of the cells to KW-2189 .
1381543	0	KW-2228	65,72	granulocyte-colony-stimulating_factor	26,63	KW-2228	granulocyte-colony-stimulating factor	MESH:C072115	1440	Chemical	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Enhanced effect of mutant granulocyte-colony-stimulating_factor -LRB- KW-2228 -RRB- on the growth of normal and leukemic hemopoietic progenitor cells in comparison with recombinant human granulocyte-colony-stimulating_factor -LRB- G-CSF -RRB- .
21474579	0	KW-2449	72,79	BCR/ABL	116,123	KW-2449	BCR/ABL	MESH:C543891	25;613	Chemical	Gene	START_ENTITY|nmod|cells cells|amod|END_ENTITY	HDAC inhibitors potentiate the activity of the BCR/ABL kinase inhibitor KW-2449 in imatinib-sensitive or - resistant BCR/ABL + leukemia cells in vitro and in vivo .
22829970	0	KW-2478	63,70	Hsp90	75,80	KW-2478	Hsp90	MESH:C551428	3320	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Anti-tumor activity against multiple_myeloma by combination of KW-2478 , an Hsp90 inhibitor , with bortezomib .
26695442	0	KW-2478	17,24	Hsp90	34,39	KW-2478	Hsp90	MESH:C551428	3320	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Phase I study of KW-2478 , a novel Hsp90 inhibitor , in patients with B-cell malignancies .
7967232	0	KW-3635	26,33	thromboxane_A2-receptor	37,60	KW-3635	thromboxane A2-receptor	MESH:C065729	100717592	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Antithrombotic effects of KW-3635 , a thromboxane_A2-receptor antagonist , in guinea_pigs .
8121085	0	KW-3635	21,28	thromboxane_A2-receptor	36,59	KW-3635	thromboxane A2-receptor	MESH:C065729	100717592	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Inhibitory effect of KW-3635 , a new thromboxane_A2-receptor antagonist , on arterial thrombosis in guinea_pigs .
8483302	0	KW-3902	32,39	adenosine_A1-receptor	49,70	KW-3902	adenosine A1-receptor	MESH:C073525	29290(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Renal tubular site of action of KW-3902 , a novel adenosine_A1-receptor antagonist , in anesthetized rats .
8839965	0	KW-3902	11,18	adenosine_A1-receptor	68,89	KW-3902	adenosine A1-receptor	MESH:C073525	29290(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Effects of KW-3902 -LRB- 8 - -LRB- noradamantan-3-yl -RRB- -1,3 - dipropylxanthine -RRB- , an adenosine_A1-receptor antagonist , on urinary excretions of various electrolytes in rats .
17923351	0	KW-3902	14,21	adenosine_A1_receptor	26,47	KW-3902	adenosine A1 receptor	MESH:C073525	134	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	The effect of KW-3902 , an adenosine_A1_receptor antagonist , on renal function and renal plasma flow in ambulatory patients with heart_failure and renal_impairment .
8130772	0	KW-3902	20,27	adenosine_A1_receptor	82,103	KW-3902	adenosine A1 receptor	MESH:C073525	403961(Tax:9615)	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|antagonist antagonist|amod|END_ENTITY	Diuretic effects of KW-3902 -LRB- 8 - -LRB- noradamantan-3-yl -RRB- -1,3 - dipropylxanthine -RRB- , a novel adenosine_A1_receptor antagonist , in conscious dogs .
15755479	0	KW-6002	0,7	MPTP	22,26	KW-6002	MPTP	MESH:C111599	19255(Tax:10090)	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|END_ENTITY	KW-6002 protects from MPTP induced dopaminergic toxicity in the mouse .
14663020	0	KW6002	100,106	adenosine_A2A_receptor	56,78	KW6002	adenosine A2A receptor	MESH:C111599	135	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Progress in pursuit of therapeutic A2A antagonists : the adenosine_A2A_receptor selective antagonist KW6002 : research and development toward a novel nondopaminergic therapy for Parkinson 's _ disease .
21509526	0	KX-01	0,5	Src	15,18	KX-01	Src	MESH:C578068	6714	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	KX-01 , a novel Src kinase inhibitor directed toward the peptide substrate site , synergizes with tamoxifen in estrogen_receptor_a positive breast_cancer .
15038459	0	KY-455	106,112	ACAT	90,94	KY-455	ACAT	MESH:C483406	100009537(Tax:9986)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Hypolipidemic and antioxidant activity of the novel acyl-CoA : cholesterol_acyltransferase -LRB- ACAT -RRB- inhibitor KY-455 in rabbits and hamsters .
22233220	0	KYP-2047	35,43	prolyl_oligopeptidase	2,23	KYP-2047	prolyl oligopeptidase	null	19072(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	A prolyl_oligopeptidase inhibitor , KYP-2047 , reduces a-synuclein protein levels and aggregates in cellular and animal models of Parkinson 's _ disease .
24746855	0	KYP-2047	60,68	prolyl_oligopeptidase	27,48	KYP-2047	prolyl oligopeptidase	null	19072(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	The beneficial effect of a prolyl_oligopeptidase inhibitor , KYP-2047 , on alpha-synuclein clearance and autophagy in A30P transgenic mouse .
2469633	0	KZ-1026	22,29	CCl4	63,67	KZ-1026	CCl4	MESH:C059615	116637(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY induced|nsubj|effect induced|nmod|END_ENTITY	-LSB- Preventive effect of KZ-1026 on acute_liver_injury induced by CCl4 in rats : histochemical , enzyme-histochemical and ultrastructural studies -RSB- .
20599768	0	Kaempferol	0,10	COX-2	32,37	Kaempferol	COX-2	MESH:C006552	19225(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Kaempferol inhibits UVB-induced COX-2 expression by suppressing Src kinase activity .
18949556	0	Kaempferol	0,10	ERK	38,41	Kaempferol	ERK	MESH:C006552	5594	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Kaempferol induces cell death through ERK and Akt-dependent down-regulation of XIAP and survivin in human glioma cells .
24278338	0	Kaempferol	0,10	ERK1/2	76,82	Kaempferol	ERK1/2	MESH:C006552	5595;5594	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|nmod|END_ENTITY	Kaempferol reduces matrix metalloproteinase-2 expression by down-regulating ERK1/2 and the activator_protein-1 signaling pathways in oral_cancer cells .
25870037	0	Kaempferol	0,10	FOXP3	73,78	Kaempferol	FOXP3	MESH:C006552	317382(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|advcl|inhibiting inhibiting|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Kaempferol enhances the suppressive function of Treg cells by inhibiting FOXP3 phosphorylation .
25808405	0	Kaempferol	0,10	FoxP3	59,64	Kaempferol	FoxP3	MESH:C006552	20371(Tax:10090)	Chemical	Gene	Tolerance|compound|START_ENTITY Tolerance|nmod|END_ENTITY	Kaempferol Promotes Transplant Tolerance by Sustaining CD4 + FoxP3 + Regulatory T Cells in the Presence of Calcineurin_Inhibitor .
17785825	0	Kaempferol	0,10	JAK3	76,80	Kaempferol	JAK3	MESH:C006552	3718	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	Kaempferol inhibits IL-4-induced STAT6 activation by specifically targeting JAK3 .
26956522	0	Kaempferol	0,10	Krt-14	19,25	Kaempferol	Krt-14	MESH:C006552	287701(Tax:10116)	Chemical	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	Kaempferol targets Krt-14 and induces cytoskeletal mineralization in osteoblasts : A mechanistic approach .
26821152	0	Kaempferol	0,10	MAO-A	30,35	Kaempferol	MAO-A	MESH:C006552	4128	Chemical	Gene	START_ENTITY|nmod|Inhibitor Inhibitor|compound|END_ENTITY	Kaempferol as Selective Human MAO-A Inhibitor : Analytical Detection in Calabrian Red Wines , Biological and Molecular Modeling Studies .
24994661	0	Kaempferol	0,10	RSK2	19,23	Kaempferol	RSK2	MESH:C006552	110651(Tax:10090)	Chemical	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Kaempferol targets RSK2 and MSK1 to suppress UV radiation-induced skin_cancer .
17785825	0	Kaempferol	0,10	STAT6	33,38	Kaempferol	STAT6	MESH:C006552	6778	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|compound|END_ENTITY	Kaempferol inhibits IL-4-induced STAT6 activation by specifically targeting JAK3 .
21927533	0	Kaempferol	0,10	VEGF	20,24	Kaempferol	VEGF	MESH:C006552	7422	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Kaempferol inhibits VEGF expression and in vitro angiogenesis through a novel ERK-NFkB-cMyc-p21 pathway .
26446489	0	Kaempferol	0,10	VEGF	129,133	Kaempferol	VEGF	MESH:C006552	30682(Tax:7955)	Chemical	Gene	Identified|compound|START_ENTITY versipellis|nsubj|Identified versipellis|nmod|Pathways Pathways|compound|END_ENTITY	Kaempferol Identified by Zebrafish Assay and Fine Fractionations Strategy from Dysosma versipellis Inhibits Angiogenesis through VEGF and FGF Pathways .
20564228	0	Kaempferol	0,10	bone_sialoprotein	22,39	Kaempferol	bone sialoprotein	MESH:C006552	24477(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|transcription transcription|amod|END_ENTITY	Kaempferol stimulates bone_sialoprotein gene transcription and new bone formation .
21625365	0	Kaempferol	0,10	p53	72,75	Kaempferol	p53	MESH:C006552	7157	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|activating activating|dobj|END_ENTITY	Kaempferol induces apoptosis in ovarian_cancer cells through activating p53 in the intrinsic pathway .
25783411	0	Kaempferol-3-O-rutinoside	0,25	FAK	90,93	Kaempferol-3-O-rutinoside	FAK	MESH:C492687	5747	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Kaempferol-3-O-rutinoside from Afgekia mahidoliae promotes keratinocyte migration through FAK and Rac1 activation .
9596803	0	Kainate	0,7	Ca2	52,55	Kainate	Ca2	MESH:D007608	54231(Tax:10116)	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Kainate receptor-mediated inhibition of presynaptic Ca2 + influx and EPSP in area CA1 of the rat hippocampus .
12909680	0	Kainate	0,7	GluR5	18,23	Kainate	GluR5	MESH:D007608	29559(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Kainate receptor -LRB- GluR5 -RRB- - mediated disinhibition of responses in rat ventrobasal thalamus allows a novel sensory processing mechanism .
9680256	0	Kainate	0,7	GluR5	8,13	Kainate	GluR5	MESH:D007608	29559(Tax:10116)	Chemical	Gene	subtype|amod|START_ENTITY subtype|amod|END_ENTITY	Kainate GluR5 receptor subtype mediates the nociceptive response to formalin in the rat .
20221278	0	Kainic_Acid	76,87	Akt	45,48	Kainic Acid	Akt	MESH:D007608	11651(Tax:10090)	Chemical	Gene	Induced|nmod|START_ENTITY Induced|compound|END_ENTITY	Inhibition of eNOS/sGC/PKG Pathway Decreases Akt Phosphorylation Induced by Kainic_Acid in Mouse Hippocampus .
26993296	0	Kainic_Acid	0,11	Elmo1	51,56	Kainic Acid	Elmo1	MESH:D007608	9844	Chemical	Gene	Induces|nsubj|START_ENTITY Induces|dobj|Expression Expression|nmod|END_ENTITY	Kainic_Acid Induces mTORC1-Dependent Expression of Elmo1 in Hippocampal Neurons .
15130707	0	Kainic_acid	0,11	CA3	28,31	Kainic acid	CA3	MESH:D007608	54232(Tax:10116)	Chemical	Gene	affect|nsubj|START_ENTITY affect|dobj|cells cells|nummod|END_ENTITY	Kainic_acid does not affect CA3 hippocampal region pyramidal cells in hypothyroid rats .
7272757	0	Kainic_acid	0,11	CA3	39,42	Kainic acid	CA3	MESH:D007608	761	Chemical	Gene	produces|nsubj|START_ENTITY produces|dobj|depolarization depolarization|nmod|cells cells|nummod|END_ENTITY	Kainic_acid produces depolarization of CA3 pyramidal cells in the vitro hippocampal slice .
18286384	0	Kainic_acid	0,11	NOP	27,30	Kainic acid	NOP	MESH:D007608	5368	Chemical	Gene	down-regulates|amod|START_ENTITY END_ENTITY|nsubj|down-regulates	Kainic_acid down-regulates NOP receptor density and gene expression in human neuroblastoma SH-SY5Y cells .
9466404	0	Kainic_acid	0,11	brain-derived_neurotrophic_factor	59,92	Kainic acid	brain-derived neurotrophic factor	MESH:D007608	627	Chemical	Gene	modulate|advcl|START_ENTITY modulate|dobj|expression expression|nmod|END_ENTITY	Kainic_acid , tetrodotoxin and light modulate expression of brain-derived_neurotrophic_factor in developing avian retinal_ganglion cells and their tectal target .
2761781	0	Kainic_acid	0,11	cholecystokinin	21,36	Kainic acid	cholecystokinin	MESH:D007608	25298(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|compound|END_ENTITY	Kainic_acid inhibits cholecystokinin release from rat hippocampal slices .
8891276	0	Kainic_acid	0,11	furin	67,72	Kainic acid	furin	MESH:D007608	18550(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Kainic_acid increases the expression of the prohormone convertases furin and PC1 in the mouse hippocampus .
12414122	0	Kainic_acid	0,11	leukemia_inhibitory_factor	20,46	Kainic acid	leukemia inhibitory factor	MESH:D007608	60584(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Kainic_acid induces leukemia_inhibitory_factor mRNA expression in the rat brain : differences in the time course of mRNA expression between the dentate gyrus and hippocampal CA1/CA3 subfields .
10471204	0	Kainic_acid	0,11	neuropeptide_Y	35,49	Kainic acid	neuropeptide Y	MESH:D007608	24604(Tax:10116)	Chemical	Gene	suppression|amod|START_ENTITY suppression|nmod|END_ENTITY	Kainic_acid seizure suppression by neuropeptide_Y is not correlated to immediate early gene mRNA levels in rats .
14600489	0	Kainic_acid	0,11	uncoupling_protein-2	24,44	Kainic acid	uncoupling protein-2	MESH:D007608	22228(Tax:10090)	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Kainic_acid upregulates uncoupling_protein-2 mRNA expression in the mouse brain .
2005421	0	Kallidin	0,8	prolactin	20,29	Kallidin	prolactin	MESH:D007609	24683(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|compound|END_ENTITY	Kallidin stimulates prolactin secretion from individual rat anterior pituitary cells .
24244819	0	Kalopanaxsaponin_A	0,18	JNK	113,116	Kalopanaxsaponin A	JNK	MESH:C460644	5599	Chemical	Gene	Effects|compound|START_ENTITY Effects|nmod|END_ENTITY	Kalopanaxsaponin_A Exerts Anti-Inflammatory Effects in Lipopolysaccharide-Stimulated Microglia via Inhibition of JNK and NF-kB/AP -1 Pathways .
23117333	0	Kalopanaxsaponin_B	0,18	IRAK1	67,72	Kalopanaxsaponin B	IRAK1	MESH:C064714	16179(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|inhibiting inhibiting|dobj|Kinase Kinase|compound|END_ENTITY	Kalopanaxsaponin_B inhibits LPS-induced inflammation by inhibiting IRAK1 Kinase .
26781327	0	Kamebakaurin	0,12	hypoxia-inducible_factor-1a	40,67	Kamebakaurin	hypoxia-inducible factor-1a	MESH:C047382	3091	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Kamebakaurin inhibits the expression of hypoxia-inducible_factor-1a and its target genes to confer antitumor activity .
1437181	0	Kanamycin	0,9	ODC	34,37	Kanamycin	ODC	MESH:D007612	24609(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Kanamycin inhibits cochlear-renal ODC in neonatal rats .
12403813	0	Karyopherins	0,12	Kap121p	52,59	Karyopherins	Kap121p	null	855356(Tax:4932)	Chemical	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Karyopherins in nuclear pore biogenesis : a role for Kap121p in the assembly of Nup53p into nuclear pore complexes .
11877450	0	Kaurane_diterpene	0,17	NF-kappa_B	42,52	Kaurane diterpene	NF-kappa B	null	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Kaurane_diterpene , kamebakaurin , inhibits NF-kappa_B by directly targeting the DNA-binding activity of p50 and blocks the expression of antiapoptotic NF-kappa_B target genes .
26408387	0	Kaurenoic_Acid	11,25	Flap	54,58	Kaurenoic Acid	Flap	MESH:C051436	29624(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of Kaurenoic_Acid and Arginine on Random Skin Flap Oxidative Stress , Inflammation , and Cytokines in Rats .
21062899	0	Kazrin	8,14	RhoGAP	64,70	Kazrin	RhoGAP	null	380247(Tax:8355)	Chemical	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Xenopus Kazrin interacts with ARVCF-catenin , spectrin and p190B RhoGAP , and modulates RhoA activity and epithelial integrity .
26660497	0	Ketamine	0,8	Brain-Derived_Neurotrophic_Factor	51,84	Ketamine	Brain-Derived Neurotrophic Factor	MESH:D007649	24225(Tax:10116)	Chemical	Gene	Release|compound|START_ENTITY Release|nmod|END_ENTITY	Ketamine Inhibits ATP-Evoked Exocytotic Release of Brain-Derived_Neurotrophic_Factor from Vesicles in Cultured Rat Astrocytes .
17522812	0	Ketamine	0,8	CD11b	46,51	Ketamine	CD11b	MESH:D007649	25021(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Ketamine inhibits polymorphonuclear leucocyte CD11b expression and respiratory burst activity in endotoxemic rats .
18655812	0	Ketamine	0,8	CO2	119,122	Ketamine	CO2	MESH:D007649	717	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|fields fields|acl|associated associated|nmod|area area|nmod|stimulation stimulation|compound|END_ENTITY	Ketamine , not fentanyl , suppresses pain-related magnetic fields associated with trigeminally innervated area following CO2 laser stimulation .
24874581	0	Ketamine	80,88	ErbB4	90,95	Ketamine	ErbB4	MESH:D007649	2066	Chemical	Gene	Signaling|nmod|START_ENTITY Signaling|amod|END_ENTITY	Downregulation of Neuregulin_1-ErbB4 Signaling and Antidepressant Properties of Ketamine : ErbB4 Expressing Pyramidal Neurons May Play a Role .
25807407	0	Ketamine	0,8	HMGB1	29,34	Ketamine	HMGB1	MESH:D007649	3146	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	Ketamine reduces LPS-induced HMGB1 via activation of the Nrf2/HO -1 pathway and NF-kB suppression .
26722488	0	Ketamine	0,8	HMGB1	19,24	Ketamine	HMGB1	MESH:D007649	25459(Tax:10116)	Chemical	Gene	effect|amod|START_ENTITY effect|nmod|expression expression|compound|END_ENTITY	Ketamine effect on HMGB1 and TLR4 expression in rats with acute_lung_injury .
11032280	0	Ketamine	0,8	NF-kappaB	38,47	Ketamine	NF-kappaB	MESH:D007649	4790	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Ketamine suppresses endotoxin-induced NF-kappaB expression .
17167854	0	Ketamine	0,8	TLR4	31,35	Ketamine	TLR4	MESH:D007649	29260(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Ketamine suppresses intestinal TLR4 expression and NF-kappaB activity in lipopolysaccharide-treated rats .
26072083	0	Ketamine	0,8	TLR4	50,54	Ketamine	TLR4	MESH:D007649	21898(Tax:10090)	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|expression expression|compound|END_ENTITY	Ketamine promotes inflammation through increasing TLR4 expression in RAW264 .7 cells .
20185670	0	Ketamine	0,8	activator_protein_1	40,59	Ketamine	activator protein 1	MESH:D007649	3726	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Ketamine inhibits transcription factors activator_protein_1 and nuclear_factor-kappaB , interleukin-8 production , as well as CD11b and CD16 expression : studies in human leukocytes and leukocytic cell lines .
20185670	0	Ketamine	0,8	activator_protein_1	40,59	Ketamine	activator protein 1	MESH:D007649	3726	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Ketamine inhibits transcription factors activator_protein_1 and nuclear_factor-kappaB , interleukin-8 production , as well as CD11b and CD16 expression : studies in human leukocytes and leukocytic cell lines .
12567337	0	Ketamine	0,8	beta-endorphin	33,47	Ketamine	beta-endorphin	MESH:D007649	18976(Tax:10090)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|nmod|END_ENTITY	Ketamine stimulates secretion of beta-endorphin from a mouse pituitary cell line .
18191973	0	Ketamine	0,8	c-Jun	179,184	Ketamine	c-Jun	MESH:D007649	3725	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|suppression suppression|nmod|phosphorylation phosphorylation|amod|END_ENTITY	Ketamine inhibits tumor_necrosis_factor-alpha and interleukin-6 gene expressions in lipopolysaccharide-stimulated macrophages through suppression of toll-like_receptor_4-mediated c-Jun N-terminal kinase phosphorylation and activator_protein-1 activation .
25737710	0	Ketamine	0,8	c-Jun	18,23	Ketamine	c-Jun	MESH:D007649	16476(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Ketamine inhibits c-Jun protein expression in mouse hippocampus following cerebral_ischemia / reperfusion injury .
10454158	0	Ketamine	0,8	c-fos	20,25	Ketamine	c-fos	MESH:D007649	314322(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Ketamine suppresses c-fos expression in dorsal horn neurons after acute constrictive sciatic_nerve_injury in the rat .
16153419	0	Ketamine	0,8	cyclooxygenase-2	68,84	Ketamine	cyclooxygenase-2	MESH:D007649	29527(Tax:10116)	Chemical	Gene	attenuates|amod|START_ENTITY attenuates|dep|role role|nmod|END_ENTITY	Ketamine attenuates liver_injury attributed to endotoxemia : role of cyclooxygenase-2 .
23696345	0	Ketamine	0,8	cytochrome_p450_aromatase	20,45	Ketamine	cytochrome p450 aromatase	MESH:D007649	60640(Tax:7955)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|amod|END_ENTITY	Ketamine attenuates cytochrome_p450_aromatase gene expression and estradiol-17b levels in zebrafish early life stages .
10553955	0	Ketamine	0,8	dopamine_transporter	40,60	Ketamine	dopamine transporter	MESH:D007649	6531	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Ketamine stereoselectively inhibits rat dopamine_transporter .
11746726	0	Ketamine	0,8	dopamine_transporter	45,65	Ketamine	dopamine transporter	MESH:D007649	574143(Tax:9544)	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|availability availability|nmod|END_ENTITY	Ketamine alters the availability of striatal dopamine_transporter as measured by -LSB- -LRB- 11 -RRB- C -RSB- beta-CFT and -LSB- -LRB- 11 -RRB- C -RSB- beta-CIT-FE in the monkey brain .
9706914	0	Ketamine	0,8	interleukin-6	24,37	Ketamine	interleukin-6	MESH:D007649	3569	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|response response|amod|END_ENTITY	Ketamine attenuates the interleukin-6 response after cardiopulmonary bypass .
18191973	0	Ketamine	0,8	tumor_necrosis_factor-alpha	18,45	Ketamine	tumor necrosis factor-alpha	MESH:D007649	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expressions expressions|amod|END_ENTITY	Ketamine inhibits tumor_necrosis_factor-alpha and interleukin-6 gene expressions in lipopolysaccharide-stimulated macrophages through suppression of toll-like_receptor_4-mediated c-Jun N-terminal kinase phosphorylation and activator_protein-1 activation .
9015328	0	Ketanserin	0,10	NGFI-A	62,68	Ketanserin	NGFI-A	MESH:D007650	24330(Tax:10116)	Chemical	Gene	blocks|nsubj|START_ENTITY blocks|nmod|END_ENTITY	Ketanserin selectively blocks acute stress-induced changes in NGFI-A and mineralocorticoid receptor gene expression in hippocampal neurons .
8569225	0	Ketanserin	0,10	erythropoietin	18,32	Ketanserin	erythropoietin	MESH:D007650	2056	Chemical	Gene	lowers|nsubj|START_ENTITY lowers|dobj|concentration concentration|compound|END_ENTITY	Ketanserin lowers erythropoietin concentration in hemodialyzed patients treated with the hormone .
3380081	0	Ketanserin	0,10	monoamine_transporter	24,45	Ketanserin	monoamine transporter	MESH:D007650	214084(Tax:10090)	Chemical	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Ketanserin binds to the monoamine_transporter of chromaffin granules and of synaptic vesicles .
16628140	0	Ketoconazole	0,12	CYP3A	26,31	Ketoconazole	CYP3A	MESH:D007654	1576	Chemical	Gene	renders|nsubj|START_ENTITY renders|dobj|status status|compound|END_ENTITY	Ketoconazole renders poor CYP3A phenotype status with midazolam as probe drug .
21895978	3	Ketoconazole	384,396	CYP3A	422,427	Ketoconazole	CYP3A	MESH:D007654	170509(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Ketoconazole , a chemical inhibitor of CYP3A , was used as positive control .
1526623	0	Ketoconazole	0,12	androgen_receptor	32,49	Ketoconazole	androgen receptor	MESH:D007654	367	Chemical	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Ketoconazole binds to the human androgen_receptor .
3111839	0	Ketoconazole	0,12	cytochrome_P-450	50,66	Ketoconazole	cytochrome P-450	MESH:D007654	4051	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|nmod|enzymes enzymes|amod|dependent dependent|amod|END_ENTITY	Ketoconazole as a possible universal inhibitor of cytochrome_P-450 dependent enzymes : its mode of inhibition .
1472102	0	Ketoconazole	0,12	cytochrome_P450c17	44,62	Ketoconazole	cytochrome P450c17	MESH:D007654	25146(Tax:10116)	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Ketoconazole inhibition of the bifunctional cytochrome_P450c17 does not affect androgen formation from the endogenous lyase substrate .
12244568	0	Ketoconazole	0,12	cytochrome_p450_3A4	99,118	Ketoconazole	cytochrome p450 3A4	MESH:D007654	1576	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|nmod|inhibition inhibition|nmod|activity activity|amod|END_ENTITY	Ketoconazole potentiates terfenadine-induced apoptosis in human Hep G2 cells through inhibition of cytochrome_p450_3A4 activity .
12230500	0	Ketoconazole	0,12	interleukin-4	24,37	Ketoconazole	interleukin-4	MESH:D007654	3565	Chemical	Gene	suppresses|amod|START_ENTITY END_ENTITY|nsubj|suppresses	Ketoconazole suppresses interleukin-4 plus anti-CD40-induced IgE class switching in surface IgE negative B cells from patients with atopic_dermatitis .
12540234	0	Ketones	0,7	neuraminidase	78,91	Ketones	neuraminidase	MESH:D007659	4758	Chemical	Gene	START_ENTITY|dep|inhibitors inhibitors|compound|END_ENTITY	Ketones as building blocks for dynamic combinatorial libraries : highly active neuraminidase inhibitors generated via selection pressure of the biological target .
19105229	0	Ketoprofen	0,10	matrix_metalloproteinase-2	48,74	Ketoprofen	matrix metalloproteinase-2	MESH:D007660	17390(Tax:10090)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|amod|END_ENTITY	Ketoprofen in topical formulation decreases the matrix_metalloproteinase-2 expression and pulmonary metastatic incidence in nude_mice with osteosarcoma .
8737754	0	Ketotifen	0,9	TNF-alpha	74,83	Ketotifen	TNF-alpha	MESH:D007665	7124	Chemical	Gene	START_ENTITY|dep|effects effects|nmod|END_ENTITY	Ketotifen in HIV-infected patients : effects on body weight and release of TNF-alpha .
8963630	0	Ki-67	14,19	MIB-1	21,26	Ki-67	MIB-1	null	57534	Chemical	Gene	Evaluation|nmod|START_ENTITY Evaluation|appos|END_ENTITY	Evaluation of Ki-67 -LRB- MIB-1 -RRB- in placentas with hydropic_change and partial and complete hydatidiform mole .
20134116	0	Ki19003	44,51	CC-chemokine_receptor_3	8,31	Ki19003	CC-chemokine receptor 3	MESH:C549482	12771(Tax:10090)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	A novel CC-chemokine_receptor_3 antagonist , Ki19003 , inhibits airway eosinophilia and subepithelial/peribronchial fibrosis induced by repeated antigen challenge in mice .
18085662	0	Ki20227	64,71	c-Fms	32,37	Ki20227	c-Fms	MESH:C517050	12978(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY kinase|ccomp|inhibits kinase|nsubj|tyrosine tyrosine|amod|END_ENTITY	The orally-active and selective c-Fms tyrosine kinase inhibitor Ki20227 inhibits disease progression in a collagen-induced arthritis mouse model .
17121910	0	Ki20227	35,42	c-fms	2,7	Ki20227	c-fms	MESH:C517050	1436	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	A c-fms tyrosine kinase inhibitor , Ki20227 , suppresses osteoclast differentiation and osteolytic_bone_destruction in a bone metastasis model .
21482024	0	Ki23057	19,26	FGFR2	2,7	Ki23057	FGFR2	MESH:C515425	2263	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	A FGFR2 inhibitor , Ki23057 , enhances the chemosensitivity of drug-resistant_gastric_cancer cells .
20079721	0	Kinamycin_F	0,11	cyclin_D3	26,35	Kinamycin F	cyclin D3	MESH:C059021	896	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	Kinamycin_F downregulates cyclin_D3 in human leukemia K562 cells .
12802729	0	Kinobeon_A	0,10	tyrosinase	23,33	Kinobeon A	tyrosinase	MESH:C477467	7299	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|compound|END_ENTITY	Kinobeon_A as a potent tyrosinase inhibitor from cell culture of safflower : in vitro comparisons of kinobeon_A with other putative inhibitors .
16895905	0	Kir2	123,127	gamma-aminobutyric_acid_receptor-interacting_factor_1	18,71	Kir2	gamma-aminobutyric acid receptor-interacting factor 1	null	66008	Chemical	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification of gamma-aminobutyric_acid_receptor-interacting_factor_1 -LRB- TRAK2 -RRB- as a trafficking factor for the K + channel Kir2 .1 .
21745559	0	Kirenol	0,7	annexin-1	28,37	Kirenol	annexin-1	MESH:C560087	25380(Tax:10116)	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	Kirenol upregulates nuclear annexin-1 which interacts with NF-kB to attenuate synovial inflammation of collagen-induced_arthritis in rats .
15546952	7	Ko143	1158,1163	ABCG2	1141,1146	Ko143	ABCG2	MESH:C541506	26357(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	This modulating activity was abrogated by treatment with a specific ABCG2 inhibitor , Ko143 , implying that PPIX may be a direct substrate for the transporter .
26148857	0	Ko143	14,19	ABCG2	40,45	Ko143	ABCG2	MESH:C541506	9429	Chemical	Gene	specific|nsubj|START_ENTITY specific|nmod|END_ENTITY	The inhibitor Ko143 is not specific for ABCG2 .
25916324	0	Kojic_Acid	39,49	Tyrosinase	98,108	Kojic Acid	Tyrosinase	MESH:C011890	7299	Chemical	Gene	Containing|compound|START_ENTITY Containing|dep|Inhibitors Inhibitors|compound|END_ENTITY	Synthesis and Biological Evaluation of Kojic_Acid Derivatives Containing 1,2,4-triazole as Potent Tyrosinase Inhibitors .
7714722	0	Kojic_acid	0,10	tyrosinase	100,110	Kojic acid	tyrosinase	MESH:C011890	7299	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|activity activity|nmod|END_ENTITY	Kojic_acid , a cosmetic skin whitening agent , is a slow-binding inhibitor of catecholase activity of tyrosinase .
17211869	0	Kojic_acid-tripeptide_amide	0,27	tyrosinase	37,47	Kojic acid-tripeptide amide	tyrosinase	null	7299	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|compound|END_ENTITY	Kojic_acid-tripeptide_amide as a new tyrosinase inhibitor .
27028885	0	Kongensin_A	16,27	HSP90	47,52	Kongensin A	HSP90	null	3320	Chemical	Gene	Inhibitor|nsubj|START_ENTITY Inhibitor|compound|END_ENTITY	Natural Product Kongensin_A is a Non-Canonical HSP90 Inhibitor that Blocks RIP3-dependent Necroptosis .
9166744	0	Koningic_acid	0,13	glyceraldehyde-3-phosphate_dehydrogenase	24,64	Koningic acid	glyceraldehyde-3-phosphate dehydrogenase	MESH:C027285	14433(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Koningic_acid -LRB- a potent glyceraldehyde-3-phosphate_dehydrogenase inhibitor -RRB- - induced fragmentation and condensation of DNA in NG108-15 cells .
17983638	0	Koninginins	0,11	phospholipase_A2	13,29	Koninginins	phospholipase A2	null	151056	Chemical	Gene	START_ENTITY|appos|inhibitors inhibitors|amod|END_ENTITY	Koninginins , phospholipase_A2 inhibitors from endophytic fungus Trichoderma koningii .
9396811	0	Kr	14,16	HUB1	0,4	Kr	HUB1	null	8427	Chemical	Gene	protein|amod|START_ENTITY END_ENTITY|appos|protein	HUB1 , a novel Kr ppel type zinc finger protein , represses the human T_cell_leukemia virus type I long terminal repeat-mediated expression .
19402821	0	Ku-0063794	0,10	mammalian_target_of_rapamycin	42,71	Ku-0063794	mammalian target of rapamycin	MESH:C541932	2475	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Ku-0063794 is a specific inhibitor of the mammalian_target_of_rapamycin -LRB- mTOR -RRB- .
17951038	0	Kurarinol	0,9	tyrosinase	11,21	Kurarinol	tyrosinase	MESH:C526229	7299	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Kurarinol , tyrosinase inhibitor isolated from the root of Sophora flavescens .
24548855	0	L-054	55,60	somatostatin_receptor_type_2	18,46	L-054	somatostatin receptor type 2	null	54305(Tax:10116)	Chemical	Gene	agonist|amod|START_ENTITY agonist|amod|END_ENTITY	Injections of the somatostatin_receptor_type_2 agonist L-054 ,264 into the amygdala block expression but not acquisition of conditioned fear in rats .
15993	0	L-2-amino-4-oxo-5-chloropentanoate	24,58	gamma-glutamylcysteine_synthetase	88,121	L-2-amino-4-oxo-5-chloropentanoate	gamma-glutamylcysteine synthetase	null	2729	Chemical	Gene	START_ENTITY|nmod|site site|nmod|END_ENTITY	Covalent interaction of L-2-amino-4-oxo-5-chloropentanoate at glutamate binding site of gamma-glutamylcysteine_synthetase .
690141	0	L-2-amino-4-oxo-5-chloropentanoic_acid	24,62	glutaminase	98,109	L-2-amino-4-oxo-5-chloropentanoic acid	glutaminase	MESH:C021959	24398(Tax:10116)	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Covalent interaction of L-2-amino-4-oxo-5-chloropentanoic_acid with rat renal phosphate-dependent glutaminase .
1327404	0	L-2-amino-4-phosphonobutanoic_acid	50,84	AP4	118,121	L-2-amino-4-phosphonobutanoic acid	AP4	MESH:C012729	445541(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	Structure-function relationships for analogues of L-2-amino-4-phosphonobutanoic_acid on the quisqualic_acid-sensitive AP4 receptor of the rat hippocampus .
6940159	0	L-2-oxothiazolidine-4-carboxylate	66,99	5-oxo-L-prolinase	103,120	L-2-oxothiazolidine-4-carboxylate	5-oxo-L-prolinase	MESH:C029536	75475(Tax:10090)	Chemical	Gene	START_ENTITY|appos|substrate substrate|amod|END_ENTITY	Stimulation of hepatic glutathione formation by administration of L-2-oxothiazolidine-4-carboxylate , a 5-oxo-L-prolinase substrate .
22732220	0	L-2-oxothiazolidine-4-carboxylic_acid	25,62	nuclear_factor_erythroid_2-related_factor_2	81,124	L-2-oxothiazolidine-4-carboxylic acid	nuclear factor erythroid 2-related factor 2	null	83619(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Anti-fibrotic effects of L-2-oxothiazolidine-4-carboxylic_acid via modulation of nuclear_factor_erythroid_2-related_factor_2 in rats .
8612042	0	L-3-chloroalanine_hydroxamate	60,89	gamma-aminobutyric_acid_aminotransferase	16,56	L-3-chloroalanine hydroxamate	gamma-aminobutyric acid aminotransferase	null	18	Chemical	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of gamma-aminobutyric_acid_aminotransferase by L-3-chloroalanine_hydroxamate .
11430884	0	L-3-hydroxyacyl-coenzyme_A	97,123	ERAB	139,143	L-3-hydroxyacyl-coenzyme A	ERAB	null	3028	Chemical	Gene	dehydrogenase|compound|START_ENTITY dehydrogenase|appos|END_ENTITY	Deposition of Alzheimer 's vascular amyloid-beta is associated with decreased expression of brain L-3-hydroxyacyl-coenzyme_A dehydrogenase -LRB- ERAB -RRB- .
12621125	0	L-3-hydroxyacyl_CoA	74,93	LCHAD	109,114	L-3-hydroxyacyl CoA	LCHAD	null	3030	Chemical	Gene	dehydrogenase|compound|START_ENTITY dehydrogenase|appos|END_ENTITY	Accumulation of 3-hydroxy-fatty_acids in the culture medium of long-chain L-3-hydroxyacyl_CoA dehydrogenase -LRB- LCHAD -RRB- and mitochondrial trifunctional protein-deficient skin fibroblasts : implications for medium chain triglyceride dietary treatment of LCHAD_deficiency .
8769975	0	L-364	39,44	CCK	24,27	L-364	CCK	null	885	Chemical	Gene	antagonist|dobj|START_ENTITY antagonist|nsubj|effects effects|nmod|END_ENTITY	Exocrine effects of the CCK antagonist L-364 ,718 in canine pancreatic autografts .
3378566	0	L-364	116,121	cholecystokinin	89,104	L-364	cholecystokinin	null	25298(Tax:10116)	Chemical	Gene	antagonist|amod|START_ENTITY antagonist|compound|END_ENTITY	Enhancement of morphine analgesia and prevention of morphine tolerance in the rat by the cholecystokinin antagonist L-364 ,718 .
2073589	0	L-365	31,36	CCK-B	12,17	L-365	CCK-B	null	887	Chemical	Gene	receptors|nmod|START_ENTITY receptors|amod|END_ENTITY	Blockade of CCK-B receptors by L-365 ,260 induces analgesia in the squirrel monkey .
1893248	0	L-365	79,84	CCK-B_receptor	53,67	L-365	CCK-B receptor	null	25706(Tax:10116)	Chemical	Gene	antagonist|amod|START_ENTITY antagonist|amod|END_ENTITY	The CCK-A_receptor antagonist devazepide but not the CCK-B_receptor antagonist L-365 ,260 reverses the effects of chronic clozapine and haloperidol on midbrain dopamine neurons .
2311658	0	L-365	40,45	CCK-B_receptor	14,28	L-365	CCK-B receptor	null	25706(Tax:10116)	Chemical	Gene	antagonist|amod|START_ENTITY antagonist|amod|END_ENTITY	The selective CCK-B_receptor antagonist L-365 ,260 enhances morphine analgesia and prevents morphine tolerance in the rat .
8887988	0	L-5-hydroxytryptophan	23,44	beta-endorphin	66,80	L-5-hydroxytryptophan	beta-endorphin	CHEBI:17780	5443	Chemical	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	Stimulatory effects of L-5-hydroxytryptophan on postdexamethasone beta-endorphin levels in major_depression .
2948652	0	L-5HTP	11,17	beta-endorphin	55,69	L-5HTP	beta-endorphin	null	5443	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of L-5HTP with and without carbidopa on plasma beta-endorphin and pain perception .
1088302	0	L-5_hydroxytryptophan-ethyl-ester	24,57	prolactin	124,133	L-5 hydroxytryptophan-ethyl-ester	prolactin	null	5617	Chemical	Gene	effect|nmod|START_ENTITY combined|nsubj|effect combined|nmod|END_ENTITY	An unexpected effect of L-5_hydroxytryptophan-ethyl-ester combined with a peripheral decarboxylase inhibitor on human serum prolactin .
1981666	0	L-6-ketopiperidine-2-carbonyl-L-leucyl-L-proline_amide	84,138	thyrotropin-releasing_hormone	153,182	L-6-ketopiperidine-2-carbonyl-L-leucyl-L-proline amide	thyrotropin-releasing hormone	null	25569(Tax:10116)	Chemical	Gene	START_ENTITY|appos|analogue analogue|amod|END_ENTITY	Memory_deficits following internal capsule lesions in rats and their improvement by L-6-ketopiperidine-2-carbonyl-L-leucyl-L-proline_amide -LRB- RGH-2202 -RRB- , a thyrotropin-releasing_hormone analogue .
8895247	0	L-733	90,95	NK1_receptor	66,78	L-733	NK1 receptor	null	6869	Chemical	Gene	antagonist|amod|START_ENTITY antagonist|amod|END_ENTITY	Enantioselective inhibition of the formalin paw late phase by the NK1_receptor antagonist L-733 ,060 in gerbils .
8839061	0	L-739	54,59	5-lipoxygenase	29,43	L-739	5-lipoxygenase	null	25290(Tax:10116)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Microsomal metabolism of the 5-lipoxygenase inhibitor L-739 ,010 : evidence for furan bioactivation .
8689939	0	L-746	55,60	5-lipoxygenase	29,43	L-746	5-lipoxygenase	null	25290(Tax:10116)	Chemical	Gene	inhibitors|dep|START_ENTITY inhibitors|amod|END_ENTITY	Microsomal metabolism of the 5-lipoxygenase inhibitors L-746 ,530 and L-739 ,010 to reactive intermediates that covalently bind to protein : the role of the 6,8-dioxabicyclo -LSB- 3.2.1 -RSB- octanyl moiety .
11050305	0	L-750355	0,8	beta3-adrenoceptor	18,36	L-750355	beta3-adrenoceptor	MESH:C417215	155	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	L-750355 , a human beta3-adrenoceptor agonist ; in vitro pharmacology and profile of activity in vivo in the rhesus_monkey .
16141790	0	L-796	43,48	PPARgamma	25,34	L-796	PPARgamma	null	25664(Tax:10116)	Chemical	Gene	agonist|amod|START_ENTITY agonist|compound|END_ENTITY	The nonthiazolidinedione PPARgamma agonist L-796 ,449 is neuroprotective in experimental stroke .
20012265	0	L-826	127,132	EP3	103,106	L-826	EP3	null	24929(Tax:10116)	Chemical	Gene	antagonist|amod|START_ENTITY antagonist|compound|END_ENTITY	Prostaglandins of the E series inhibit monoamine release via EP3 receptors : proof with the competitive EP3 receptor antagonist L-826 ,266 .
16020631	0	L-97-1	42,48	A1_adenosine_receptor	8,29	L-97-1	A1 adenosine receptor	null	100328615(Tax:9986)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	A novel A1_adenosine_receptor antagonist , L-97-1 -LSB- 3 - -LSB- 2 - -LRB- 4-aminophenyl -RRB- - ethyl -RSB- -8 - benzyl-7 - -LCB- 2-ethyl - -LRB- 2-hydroxy-ethyl -RRB- - amino -RSB- - ethyl -RCB- -1 - propyl-3 ,7 - dihydro-purine-2 ,6 - dione -RSB- , reduces allergic responses to house dust mite in an allergic rabbit model of asthma .
2984024	0	L-AMP-PCP	0,9	ATP_receptor	14,26	L-AMP-PCP	ATP receptor	null	100135591(Tax:10141)	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	L-AMP-PCP , an ATP_receptor agonist in guinea-pig bladder , is inactive on taenia coli .
14592619	0	L-AP4	58,63	mGluR4	11,17	L-AP4	mGluR4	MESH:C114785	14802(Tax:10090)	Chemical	Gene	Changes|nmod|START_ENTITY Changes|nmod|END_ENTITY	Changes of mGluR4 and the effects of its specific agonist L-AP4 in a rodent model of diffuse_brain_injury .
25335675	0	L-ARGININE	10,20	INSULIN	40,47	L-ARGININE	INSULIN	CHEBI:16467	3630	Chemical	Gene	SUPPLEMENTATION|compound|START_ENTITY SUPPLEMENTATION|nmod|RESISTANCE RESISTANCE|compound|END_ENTITY	EFFECT OF L-ARGININE SUPPLEMENTATION ON INSULIN RESISTANCE AND ADIPOCITOKINES LEVELS IN HEAD AND NECK CANCER NON DIABETIC PATIENTS AFTER SURGERY .
6761713	0	L-Alanyl-L-alanine_phenylamides	139,170	dipeptidyl_peptidase_IV	90,113	L-Alanyl-L-alanine phenylamides	dipeptidyl peptidase IV	null	1803	Chemical	Gene	activities|nmod|START_ENTITY activities|amod|END_ENTITY	Judging models in QSAR - and LFE-like studies if there are no replications : correlation of dipeptidyl_peptidase_IV hydrolytic activities of L-Alanyl-L-alanine_phenylamides .
23965885	0	L-Arg	12,17	PI3K	35,39	L-Arg	PI3K	CHEBI:16467	298947(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of L-Arg on expression of PI3K and PKB in liver among low-birth-weight newborn rats -RSB- .
11300497	0	L-Arginine	0,10	CD3zeta	71,78	L-Arginine	CD3zeta	CHEBI:16467	919	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	L-Arginine regulates the expression of the T-cell_receptor_zeta_chain -LRB- CD3zeta -RRB- in Jurkat cells .
15922712	0	L-Arginine	0,10	CD3zeta	21,28	L-Arginine	CD3zeta	CHEBI:16467	919	Chemical	Gene	modulates|amod|START_ENTITY END_ENTITY|nsubj|modulates	L-Arginine modulates CD3zeta expression and T cell function in activated human T lymphocytes .
25501750	0	L-Arginine	27,37	SIRT-1	17,23	L-Arginine	SIRT-1	CHEBI:16467	309757(Tax:10116)	Chemical	Gene	Protection|compound|START_ENTITY Role|nmod|Protection Role|nmod|END_ENTITY	A Novel Role for SIRT-1 in L-Arginine Protection against STZ Induced Myocardial_Fibrosis in Rats .
22137265	0	L-Arginine	0,10	mTOR	26,30	L-Arginine	mTOR	CHEBI:16467	21977(Tax:10090)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	L-Arginine stimulates the mTOR signaling pathway and protein synthesis in porcine trophectoderm cells .
8905031	0	L-Asparagine	0,12	L-asparaginase	143,157	L-Asparagine	L-asparaginase	CHEBI:17196	80150	Chemical	Gene	depletion|amod|START_ENTITY depletion|nmod|END_ENTITY	L-Asparagine depletion in plasma and cerebro-spinal fluid of children with acute_lymphoblastic_leukemia during subsequent exposures to Erwinia L-asparaginase .
10575305	0	L-Carnitine	0,11	erythropoietin	58,72	L-Carnitine	erythropoietin	MESH:D002331	24335(Tax:10116)	Chemical	Gene	effects|amod|START_ENTITY treated|nsubj|effects treated|nmod|END_ENTITY	L-Carnitine effects on anemia in uremic rats treated with erythropoietin .
17055656	0	L-DOPA	50,56	JunD	22,26	L-DOPA	JunD	MESH:D007980	24518(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY END_ENTITY|nmod|treatment	Expression pattern of JunD after acute or chronic L-DOPA treatment : comparison with deltaFosB .
10773222	0	L-DOPA	31,37	L-amino_acid_decarboxylase	110,136	L-DOPA	L-amino acid decarboxylase	MESH:D007980	24311(Tax:10116)	Chemical	Gene	derivative|nmod|START_ENTITY fails|nsubj|derivative fails|xcomp|inhibit inhibit|dobj|END_ENTITY	The O-methylated derivative of L-DOPA , 3-O-methyl-L-DOPA , fails to inhibit neuronal and non-neuronal aromatic L-amino_acid_decarboxylase .
15836622	0	L-DOPA	137,143	L-amino_acid_decarboxylase	64,90	L-DOPA	L-amino acid decarboxylase	MESH:D007980	1644	Chemical	Gene	toxicity|amod|START_ENTITY cultures|nmod|toxicity protects|dobj|cultures protects|nsubj|transfer transfer|nmod|END_ENTITY	Adeno-associated virus-mediated gene transfer of human aromatic L-amino_acid_decarboxylase protects mixed striatal primary cultures from L-DOPA toxicity .
20542064	0	L-DOPA	173,179	L-amino_acid_decarboxylase	96,122	L-DOPA	L-amino acid decarboxylase	MESH:D007980	24311(Tax:10116)	Chemical	Gene	actions|nmod|START_ENTITY evidence|nmod|actions response|dep|evidence response|acl|L-DOPA L-DOPA|nmod|rats rats|nmod|inhibition inhibition|nmod|END_ENTITY	Locomotor response to L-DOPA in reserpine-treated rats following central inhibition of aromatic L-amino_acid_decarboxylase : further evidence for non-dopaminergic actions of L-DOPA and its metabolites .
20542064	0	L-DOPA	22,28	L-amino_acid_decarboxylase	96,122	L-DOPA	L-amino acid decarboxylase	MESH:D007980	24311(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|rats rats|nmod|inhibition inhibition|nmod|END_ENTITY	Locomotor response to L-DOPA in reserpine-treated rats following central inhibition of aromatic L-amino_acid_decarboxylase : further evidence for non-dopaminergic actions of L-DOPA and its metabolites .
6983619	0	L-DOPA	94,100	L-amino_acid_decarboxylase	53,79	L-DOPA	L-amino acid decarboxylase	MESH:D007980	24311(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Effect of pyridoxal_phosphate deficiency on aromatic L-amino_acid_decarboxylase activity with L-DOPA and L-5-hydroxytryptophan as substrates in rats .
7697371	0	L-DOPA	92,98	L-amino_acid_decarboxylase	157,183	L-DOPA	L-amino acid decarboxylase	MESH:D007980	24311(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|involvement involvement|nmod|END_ENTITY	Immunohistochemical evidence that central serotonin neurons produce dopamine from exogenous L-DOPA in the rat , with reference to the involvement of aromatic L-amino_acid_decarboxylase .
18752647	0	L-DOPA	67,73	RPTP-zeta/beta	22,36	L-DOPA	RPTP-zeta/beta	MESH:D007980	25613(Tax:10116)	Chemical	Gene	up-regulated|nmod|START_ENTITY up-regulated|nsubjpass|expression expression|amod|END_ENTITY	Pleiotrophin receptor RPTP-zeta/beta expression is up-regulated by L-DOPA in striatal medium spiny neurons of parkinsonian rats .
10400088	0	L-DOPA	132,138	TNF-alpha	146,155	L-DOPA	TNF-alpha	MESH:D007980	24835(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|induction induction|amod|END_ENTITY	Increase in level of tumor_necrosis_factor _ -LRB- TNF -RRB- - alpha in 6-hydroxydopamine-lesioned striatum in rats without influence of systemic L-DOPA on the TNF-alpha induction .
9113132	0	L-DOPA	52,58	catalase	14,22	L-DOPA	catalase	MESH:D007980	24248(Tax:10116)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of catalase in mesencephalic cultures by L-DOPA and dopamine .
11412836	0	L-DOPA	88,94	catechol-O-methyltransferase	19,47	L-DOPA	catechol-O-methyltransferase	MESH:D007980	24267(Tax:10116)	Chemical	Gene	availability|nmod|START_ENTITY enhances|dobj|availability enhances|nsubj|BIA_3-202 BIA_3-202|appos|inhibitor inhibitor|amod|END_ENTITY	BIA_3-202 , a novel catechol-O-methyltransferase inhibitor , enhances the availability of L-DOPA to the brain and reduces its O-methylation .
12660477	0	L-DOPA	99,105	catechol-O-methyltransferase	19,47	L-DOPA	catechol-O-methyltransferase	MESH:D007980	24267(Tax:10116)	Chemical	Gene	O-methylation|nmod|START_ENTITY reduces|dobj|O-methylation reduces|nsubj|BIA_3-202 BIA_3-202|appos|inhibitor inhibitor|amod|END_ENTITY	BIA_3-202 , a novel catechol-O-methyltransferase inhibitor , reduces the peripheral O-methylation of L-DOPA and enhances its availability to the brain .
19930170	0	L-DOPA	61,67	catechol-O-methyltransferase	29,57	L-DOPA	catechol-O-methyltransferase	MESH:D007980	12846(Tax:10090)	Chemical	Gene	metabolism|amod|START_ENTITY END_ENTITY|nmod|metabolism	Importance of membrane-bound catechol-O-methyltransferase in L-DOPA metabolism : a pharmacokinetic study in two types of Comt gene modified mice .
8615170	0	L-DOPA	85,91	catechol-O-methyltransferase	11,39	L-DOPA	catechol-O-methyltransferase	MESH:D007980	1312	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|inhibition inhibition|amod|END_ENTITY	Effects of catechol-O-methyltransferase -LRB- COMT -RRB- inhibition on the pharmacokinetics of L-DOPA .
14751427	0	L-DOPA	109,115	growth_hormone	82,96	L-DOPA	growth hormone	MESH:D007980	2688	Chemical	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Effects of antidepressant treatment on thyrotropin-releasing_hormone stimulation , growth_hormone response to L-DOPA , and dexamethasone suppression tests in major depressive patients .
406134	0	L-DOPA	83,89	growth_hormone	29,43	L-DOPA	growth hormone	MESH:D007980	2688	Chemical	Gene	administration|amod|START_ENTITY Effect|nmod|administration Effect|nmod|END_ENTITY	Effect of sulpiride on serum growth_hormone and prolactin concentrations following L-DOPA administration in man .
4673195	0	L-DOPA	106,112	growth_hormone	41,55	L-DOPA	growth hormone	MESH:D007980	2688	Chemical	Gene	Fluctuations|nmod|START_ENTITY Fluctuations|nmod|concentration concentration|nmod|END_ENTITY	-LSB- Fluctuations of plasma concentration of growth_hormone -LRB- GH -RRB- and cortisol in man during administration of L-DOPA .
23607456	0	L-DOPA	0,6	prolactin	18,27	L-DOPA	prolactin	MESH:D007980	280901(Tax:9913)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|secretion secretion|compound|END_ENTITY	L-DOPA attenuates prolactin secretion in response to isolation stress in Holstein steers .
4216257	0	L-DOPA	0,6	prolactin	26,35	L-DOPA	prolactin	MESH:D007980	5617	Chemical	Gene	control|amod|START_ENTITY control|nmod|secretion secretion|compound|END_ENTITY	L-DOPA and the control of prolactin secretion .
10849837	0	L-DOPA	0,6	tyrosinase	33,43	L-DOPA	tyrosinase	MESH:D007980	7299	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	L-DOPA production by immobilized tyrosinase .
18624322	0	L-DOPA	0,6	tyrosinase	23,33	L-DOPA	tyrosinase	MESH:D007980	7299	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	L-DOPA production from tyrosinase immobilized on nylon_6 ,6 .
9326301	0	L-DOPA	0,6	tyrosine_hydroxylase	26,46	L-DOPA	tyrosine hydroxylase	MESH:D007980	7054	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	L-DOPA is a substrate for tyrosine_hydroxylase .
16363132	0	L-Glutamic_acid	1,16	tumor_necrosis_factor	51,72	L-Glutamic acid	tumor necrosis factor	CHEBI:16015	7124	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|effect effect|nmod|END_ENTITY	-LSB- L-Glutamic_acid modulates the cytotoxic effect of tumor_necrosis_factor in the HL-60 cell line -RSB- .
11785976	0	L-Lactate	13,22	LldP	56,60	L-Lactate	LldP	CHEBI:16651	3654502(Tax:562)	Chemical	Gene	Transport|nmod|START_ENTITY Transport|nmod|END_ENTITY	Transport of L-Lactate , D-Lactate , and glycolate by the LldP and GlcA membrane carriers of Escherichia_coli .
2156551	0	L-Lactate	0,9	cytochrome_c	10,22	L-Lactate	cytochrome c	CHEBI:16651	54205	Chemical	Gene	reductase|amod|START_ENTITY reductase|amod|END_ENTITY	L-Lactate cytochrome_c reductase : rapid kinetic studies of electron transfers within the flavocytochrome b2-cytochrome_c assembly .
12219997	0	L-NAME	11,17	IL-1beta	41,49	L-NAME	IL-1beta	null	100008990(Tax:9986)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|amod|END_ENTITY	Effects of L-NAME and timolol on aqueous IL-1beta , IL-6 , IL-8 , TNF-alpha and NO levels after Nd : YAG laser iridotomy in rabbits .
9722036	0	L-NAME	10,16	IL-6	78,82	L-NAME	IL-6	null	3569	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|nmod|END_ENTITY	Effect of L-NAME , an inhibitor of nitric_oxide synthesis , on plasma levels of IL-6 , IL-8 , TNF_alpha and nitrite/nitrate in human septic_shock .
15284344	0	L-NAME	38,44	Nitric_oxide_synthase	0,21	L-NAME	Nitric oxide synthase	null	4843	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Nitric_oxide_synthase inhibition with L-NAME reduces maximal oxygen uptake but not gas exchange threshold during incremental cycle exercise in man .
11549221	0	L-NAME	37,43	nitric_oxide_synthase	4,25	L-NAME	nitric oxide synthase	null	18125(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	The nitric_oxide_synthase inhibitor , L-NAME , block phencyclidine-induced disruption of prepulse inhibition in mice .
9141060	0	L-NAME	61,67	nitric_oxide_synthase	71,92	L-NAME	nitric oxide synthase	null	4843	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Blockade_of_joint_inflammation and secondary hyperalgesia by L-NAME , a nitric_oxide_synthase inhibitor .
8938822	0	L-NAME	32,38	prodynorphin	68,80	L-NAME	prodynorphin	null	29190(Tax:10116)	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|dobj|expression expression|compound|END_ENTITY	Nitric_oxide synthase inhibitor L-NAME prevents amphetamine-induced prodynorphin gene expression in the rat .
22995863	0	L-NIL	16,21	iNOS	0,4	L-NIL	iNOS	null	24599(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	iNOS inhibitor , L-NIL , reverses burn-induced glycogen_synthase_kinase-3b activation in skeletal muscle of rats .
20480196	0	L-Phe	31,36	phenylalanine_hydroxylase	40,65	L-Phe	phenylalanine hydroxylase	null	174401(Tax:6239)	Chemical	Gene	binding|nmod|START_ENTITY binding|acl|END_ENTITY	Superstoichiometric binding of L-Phe to phenylalanine_hydroxylase from Caenorhabditis_elegans : evolutionary implications .
11340646	0	L-Serine	0,8	3-phosphoglycerate_dehydrogenase	85,117	L-Serine	3-phosphoglycerate dehydrogenase	CHEBI:33384	58835(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activities activities|acl:relcl|express express|dobj|level level|nmod|END_ENTITY	L-Serine regulates the activities of microglial cells that express very low level of 3-phosphoglycerate_dehydrogenase , an enzyme for L-Serine biosynthesis .
11340646	0	L-Serine	133,141	3-phosphoglycerate_dehydrogenase	85,117	L-Serine	3-phosphoglycerate dehydrogenase	CHEBI:33384	58835(Tax:10116)	Chemical	Gene	biosynthesis|amod|START_ENTITY enzyme|nmod|biosynthesis END_ENTITY|appos|enzyme	L-Serine regulates the activities of microglial cells that express very low level of 3-phosphoglycerate_dehydrogenase , an enzyme for L-Serine biosynthesis .
24103518	0	L-Threonine	0,11	heat_shock_protein	20,38	L-Threonine	heat shock protein	CHEBI:16857	290549(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	L-Threonine induces heat_shock_protein expression and decreases apoptosis in heat-stressed intestinal epithelial cells .
15890358	0	L-Thyroxine	0,11	Akt	22,25	L-Thyroxine	Akt	MESH:D013974	24185(Tax:10116)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	L-Thyroxine activates Akt signaling in the heart .
26349500	0	L-Tryptophan	113,125	GPR139	0,6	L-Tryptophan	GPR139	CHEBI:16828	293545(Tax:10116)	Chemical	Gene	Activated|nmod|START_ENTITY Activated|nsubjpass|END_ENTITY	GPR139 , an Orphan_Receptor Highly Enriched in the Habenula and Septum , is Activated by the Essential Amino_Acids L-Tryptophan and L-Phenylalanine .
7460826	0	L-Tryptophan	0,12	growth_hormone	42,56	L-Tryptophan	growth hormone	CHEBI:16828	81668(Tax:10116)	Chemical	Gene	injection|amod|START_ENTITY enhances|nsubj|injection enhances|dobj|secretion secretion|compound|END_ENTITY	L-Tryptophan injection enhances pulsatile growth_hormone secretion in the rat .
8740629	0	L-acetylcarnitine	84,101	Acetylcholinesterase	0,20	L-acetylcarnitine	Acetylcholinesterase	CHEBI:57589	83817(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY activity|dep|effect activity|amod|END_ENTITY	Acetylcholinesterase activity of synaptic plasma membranes during ageing : effect of L-acetylcarnitine .
25284	0	L-alanine	17,26	BHK-21-C13	59,69	L-alanine	BHK-21-C13	CHEBI:16977	3229	Chemical	Gene	transport|nmod|START_ENTITY transport|nmod|END_ENTITY	The transport of L-alanine by the hamster kidney cell line BHK-21-C13 .
10567848	0	L-alanine	54,63	epidermal_growth_factor	10,33	L-alanine	epidermal growth factor	CHEBI:16977	397083(Tax:9823)	Chemical	Gene	transport|amod|START_ENTITY Effect|nmod|transport Effect|nmod|END_ENTITY	Effect of epidermal_growth_factor on sodium-dependent L-alanine transport in LLC-PK1 cells .
3827951	0	L-alanosyl-5-aminoimidazole-4-carboxylic_acid_ribonucleotide	40,100	adenylosuccinate_lyase	14,36	L-alanosyl-5-aminoimidazole-4-carboxylic acid ribonucleotide	adenylosuccinate lyase	null	315150(Tax:10116)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of adenylosuccinate_lyase by L-alanosyl-5-aminoimidazole-4-carboxylic_acid_ribonucleotide -LRB- alanosyl-AICOR -RRB- .
26014704	0	L-alanyl-L-glutamine	11,31	insulin-like_growth_factor-1	49,77	L-alanyl-L-glutamine	insulin-like growth factor-1	CHEBI:73788	24482(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Effect of L-alanyl-L-glutamine on expression of insulin-like_growth_factor-1 in intestinal tissues of low-birth-weight newborn rats with hypoxia/reoxygenation-induced intestinal_injury -RSB- .
17245368	0	L-alpha-amino-acid	53,71	GPRC6A	42,48	L-alpha-amino-acid	GPRC6A	CHEBI:15705	210198(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY END_ENTITY|appos|receptor	Pharmacological characterization of mouse GPRC6A , an L-alpha-amino-acid receptor modulated by divalent cations .
3932344	0	L-alpha-dipalmitoylphosphatidylcholine	73,111	apolipoprotein_A-I	19,37	L-alpha-dipalmitoylphosphatidylcholine	apolipoprotein A-I	null	335	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	The interaction of apolipoprotein_A-I with small unilamellar vesicles of L-alpha-dipalmitoylphosphatidylcholine .
8152614	0	L-alpha-glyceryl_phosphorylcholine	78,112	choline_acetyltransferase	126,151	L-alpha-glyceryl phosphorylcholine	choline acetyltransferase	MESH:D005997	290567(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|END_ENTITY	Effect of ipsilateral lesioning of the nucleus basalis magnocellularis and of L-alpha-glyceryl_phosphorylcholine treatment on choline_acetyltransferase and acetylcholinesterase in the rat fronto-parietal cortex .
4691682	0	L-alpha-methyldopahydrazine	61,88	DOPA_decarboxylase	120,138	L-alpha-methyldopahydrazine	DOPA decarboxylase	CHEBI:39585	1644	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Treatment of Parkinson 's _ disease with levodopa combined with L-alpha-methyldopahydrazine , an inhibitor of extracerebral DOPA_decarboxylase .
1875781	0	L-amino_acid	42,54	Catechol-O-methyltransferase	0,28	L-amino acid	Catechol-O-methyltransferase	CHEBI:15705	1312	Chemical	Gene	activities|amod|START_ENTITY activities|amod|END_ENTITY	Catechol-O-methyltransferase and aromatic L-amino_acid decarboxylase activities in human gastrointestinal tissues .
8996517	0	L-amino_acid	0,12	LOX	22,25	L-amino acid	LOX	CHEBI:15705	14204(Tax:10090)	Chemical	Gene	oxidase|amod|START_ENTITY oxidase|appos|END_ENTITY	L-amino_acid oxidase -LRB- LOX -RRB- modulation of melphalan activity against intracranial_glioma .
12428172	0	L-amino_acid	0,12	calcium-sensing_receptor	28,52	L-amino acid	calcium-sensing receptor	CHEBI:15705	846	Chemical	Gene	sensing|amod|START_ENTITY sensing|nmod|END_ENTITY	L-amino_acid sensing by the calcium-sensing_receptor : a general mechanism for coupling protein and calcium metabolism ?
11263376	0	L-amino_acid	52,64	tyrosine_hydroxylase	18,38	L-amino acid	tyrosine hydroxylase	CHEBI:15705	7054	Chemical	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Cotransduction of tyrosine_hydroxylase and aromatic L-amino_acid decarboxylase genes into cultured striatal cells using adeno-associated virus vectors .
21067292	0	L-arginine	10,20	Bcl-2	42,47	L-arginine	Bcl-2	CHEBI:16467	596	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	Effect of L-arginine on the expression of Bcl-2 and Bax in the placenta of fetal_growth_restriction .
8662674	1	L-arginine	113,123	CAT-1	155,160	L-arginine	CAT-1	CHEBI:16467	25648(Tax:10116)	Chemical	Gene	transport|amod|START_ENTITY Regulation|nmod|transport Regulation|nmod|END_ENTITY	Regulation of L-arginine transport and no production by CAT-1 , CAT-2A , and CAT-2B .
11950832	0	L-arginine	58,68	CD3zeta	30,37	L-arginine	CD3zeta	CHEBI:16467	919	Chemical	Gene	chain|nmod|START_ENTITY chain|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of T cell receptor CD3zeta chain expression by L-arginine .
23959939	0	L-arginine	5,15	GLP-1	27,32	L-arginine	GLP-1	CHEBI:16467	14526(Tax:10090)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|compound|END_ENTITY	Oral L-arginine stimulates GLP-1 secretion to improve glucose tolerance in male mice .
23557067	0	L-arginine	10,20	HSP70	24,29	L-arginine	HSP70	CHEBI:16467	3308	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of L-arginine on HSP70 expression in liver in weanling piglets .
24049535	0	L-arginine	13,23	HSP70	41,46	L-arginine	HSP70	CHEBI:16467	266759(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Influence of L-arginine on expression of HSP70 and p-53 proteins - early biomarkers of cellular danger in renal tubular cells .
21839495	0	L-arginine	102,112	IGFBP-4	60,67	L-arginine	IGFBP-4	CHEBI:16467	16010(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Expression Expression|nmod|END_ENTITY	Expression of insulin-like_growth_factor_binding_protein-4 -LRB- IGFBP-4 -RRB- in acute pancreatitis induced by L-arginine in mice .
21871446	0	L-arginine	27,37	Insulin	0,7	L-arginine	Insulin	CHEBI:16467	3630	Chemical	Gene	transport|amod|START_ENTITY stimulates|dobj|transport stimulates|nsubj|END_ENTITY	Insulin rapidly stimulates L-arginine transport in human aortic endothelial cells via Akt .
16216417	15	L-arginine	773,783	NOS_1	794,799	L-arginine	NOS 2	CHEBI:16467	4843	Chemical	Gene	absence|nmod|START_ENTITY END_ENTITY|nmod|absence	In the absence of L-arginine , however , NOS_1 generation of O2 .
21342627	0	L-arginine	11,21	Pax2	25,29	L-arginine	Pax2	CHEBI:16467	293992(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	-LSB- Effect of L-arginine on Pax2 expression in the kidneys of pup rats with intrauterine_growth_retardation -RSB- .
15834311	0	L-arginine	68,78	Prolactin	0,9	L-arginine	Prolactin	CHEBI:16467	24683(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY involvement|nmod|synthase secretion|dep|involvement secretion|compound|END_ENTITY	Prolactin secretion in hypothyroid endotoxemic rats : involvement of L-arginine and nitric_oxide synthase .
9527396	0	L-arginine	0,10	RANTES	63,69	L-arginine	RANTES	CHEBI:16467	81780(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|nmod|END_ENTITY	L-arginine suppresses lipopolysaccharide-induced expression of RANTES in glomeruli .
21972595	0	L-arginine	1,11	Th1	21,24	L-arginine	Th1	CHEBI:16467	57314(Tax:10090)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|response response|amod|END_ENTITY	-LSB- L-arginine enhances Th1 immune response against Plasmodium_yoelii 17XL infection in DBA/2 mice via activation of dendritic cells -RSB- .
8889032	0	L-arginine	82,92	angiotensin_II	19,33	L-arginine	angiotensin II	CHEBI:16467	24179(Tax:10116)	Chemical	Gene	infusion|amod|START_ENTITY END_ENTITY|nmod|infusion	Role of endogenous angiotensin_II in renal hemodynamic and excretory responses to L-arginine infusion .
15452864	0	L-arginine	0,10	dopamine_transporter	21,41	L-arginine	dopamine transporter	CHEBI:16467	24898(Tax:10116)	Chemical	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	L-arginine increases dopamine_transporter activity in rat striatum via a nitric_oxide_synthase-dependent mechanism .
10051127	0	L-arginine	53,63	iNOS	8,12	L-arginine	iNOS	CHEBI:16467	24599(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Role Role|nmod|END_ENTITY	Role of iNOS in the vasodilator responses induced by L-arginine in the middle cerebral artery from normotensive and hypertensive rats .
13678705	0	L-arginine	56,66	nitric_oxide_synthase	14,35	L-arginine	nitric oxide synthase	CHEBI:16467	4843	Chemical	Gene	conversion|nmod|START_ENTITY conversion|amod|END_ENTITY	Inhibition of nitric_oxide_synthase -LRB- NOS -RRB- conversion of L-arginine to nitric_oxide -LRB- NO -RRB- decreases low density mononuclear cell -LRB- LD MNC -RRB- trans-endothelial migration and cytokine output .
15748708	0	L-arginine	0,10	nitric_oxide_synthase	30,51	L-arginine	nitric oxide synthase	CHEBI:16467	4842	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|compound|END_ENTITY	L-arginine regulates neuronal nitric_oxide_synthase production of superoxide and hydrogen_peroxide .
16169754	0	L-arginine	0,10	nitric_oxide_synthase	54,75	L-arginine	nitric oxide synthase	CHEBI:16467	4843	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|dobj|expression expression|nmod|END_ENTITY	L-arginine prevents reduced expression of endothelial nitric_oxide_synthase -LRB- NOS -RRB- in pulmonary arterioles of broilers exposed to cool temperatures .
7499198	0	L-arginine	75,85	nitric_oxide_synthase	140,161	L-arginine	nitric oxide synthase	CHEBI:16467	4843	Chemical	Gene	interactions|nmod|START_ENTITY resonance|nmod|interactions Characterization|nmod|resonance Characterization|nmod|region region|nmod|END_ENTITY	Characterization by electron paramagnetic resonance of the interactions of L-arginine and L-thiocitrulline with the heme cofactor region of nitric_oxide_synthase .
7519607	0	L-arginine	0,10	nitric_oxide_synthase	77,98	L-arginine	nitric oxide synthase	CHEBI:16467	4843	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	L-arginine and calmodulin regulation of the heme_iron reactivity in neuronal nitric_oxide_synthase .
10739497	0	L-arginine	15,25	prolactin	44,53	L-arginine	prolactin	CHEBI:16467	5617	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|release release|nmod|END_ENTITY	The effects of L-arginine on the release of prolactin from decidual explants in vitro .
11593518	0	L-arginine	8,18	vascular_cell_adhesion_molecule-1	44,77	L-arginine	vascular cell adhesion molecule-1	CHEBI:16467	25361(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|nmod|END_ENTITY	Dietary L-arginine attenuates expression of vascular_cell_adhesion_molecule-1 in the aortae of hypercholesterolemic rats .
11085948	0	L-aromatic_amino_acids	36,58	dopa_decarboxylase	12,30	L-aromatic amino acids	dopa decarboxylase	null	1644	Chemical	Gene	Reaction|nmod|START_ENTITY Reaction|nmod|END_ENTITY	Reaction of dopa_decarboxylase with L-aromatic_amino_acids under aerobic and anaerobic conditions .
23293470	0	L-ascorbic_Acid	10,25	hsp70	33,38	L-ascorbic Acid	hsp70	MESH:D001205	44920(Tax:7227)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|Expression Expression|amod|END_ENTITY	Effect of L-ascorbic_Acid on the hsp70 Expression and Tissue Damage in the Third Instar Larvae of Transgenic Drosophila_melanogaster -LRB- hsp70-lacZ -RRB- Bg -LRB- 9 -RRB- .
2833447	0	L-ascorbic_acid	0,15	5-lipoxygenase	26,40	L-ascorbic acid	5-lipoxygenase	MESH:D001205	240	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activity activity|amod|END_ENTITY	L-ascorbic_acid modulates 5-lipoxygenase activity in human polymorphonuclear leukocytes .
15368354	0	L-ascorbic_acid	0,15	NF-kappaB	53,62	L-ascorbic acid	NF-kappaB	MESH:D001205	4790	Chemical	Gene	represses|amod|START_ENTITY constitutive|nsubj|represses constitutive|dobj|activation activation|nmod|expression expression|amod|END_ENTITY	L-ascorbic_acid represses constitutive activation of NF-kappaB and COX-2 expression in human acute_myeloid_leukemia , HL-60 .
17664058	0	L-ascorbic_acid	46,61	alkaline_phosphatase	13,33	L-ascorbic acid	alkaline phosphatase	MESH:D001205	250	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Induction of alkaline_phosphatase activity by L-ascorbic_acid in human osteoblastic cells : a potential role for CK2 and Ikaros .
8216233	0	L-ascorbic_acid	10,25	tyrosinase	59,69	L-ascorbic acid	tyrosinase	MESH:D001205	7299	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|nmod|END_ENTITY	Effect of L-ascorbic_acid on the monophenolase activity of tyrosinase .
1742729	0	L-asparagine	21,33	L-asparaginase	53,67	L-asparagine	L-asparaginase	CHEBI:17196	80150	Chemical	Gene	START_ENTITY|nmod|presence presence|nmod|END_ENTITY	Measurement of serum L-asparagine in the presence of L-asparaginase requires the presence of an L-asparaginase inhibitor .
11557236	0	L-aspartate	19,30	EAAC-1	59,65	L-aspartate	EAAC-1	CHEBI:29991	25550(Tax:10116)	Chemical	Gene	transport|amod|START_ENTITY transport|nmod|END_ENTITY	Characteristics of L-aspartate transport and expression of EAAC-1 in sarcolemmal vesicles and isolated cells from rat heart .
8348975	1	L-aspartate	130,141	L-asparaginase	104,118	L-aspartate	L-asparaginase	CHEBI:29991	80150	Chemical	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Crystal structure of Erwinia chrysanthemi L-asparaginase with bound L-aspartate .
9309222	0	L-canaline	48,58	ornithine_aminotransferase	6,32	L-canaline	ornithine aminotransferase	MESH:C001926	4942	Chemical	Gene	complexed|nmod|START_ENTITY END_ENTITY|acl|complexed	Human ornithine_aminotransferase complexed with L-canaline and gabaculine : structural basis for substrate recognition .
12064516	0	L-canavanine	133,145	TRH	35,38	L-canavanine	TRH	CHEBI:405237	7200	Chemical	Gene	effect|nmod|START_ENTITY secretion|dep|effect secretion|nmod|END_ENTITY	Cell swelling induced secretion of TRH by posterior pituitary , hypothalamic paraventricular nucleus and pancreatic islets : effect of L-canavanine .
23624824	4	L-canavanine	682,694	iNOS	708,712	L-canavanine	nNOS	CHEBI:405237	24598(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	L-canavanine , a selective iNOS inhibitor , partly blocked CoCl2-induced cytotoxicity , apoptosis and mitochondrial insult .
11230720	0	L-canavanine	0,12	inducible_NO_synthase	39,60	L-canavanine	inducible NO synthase	CHEBI:405237	403822(Tax:9615)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	L-canavanine , a selective inhibitor of inducible_NO_synthase , increases plasma endothelin-1 concentrations in dogs with endotoxic_shock .
19406626	0	L-carnitine	34,45	ACE	56,59	L-carnitine	ACE	MESH:D002331	24310(Tax:10116)	Chemical	Gene	treatment|nmod|START_ENTITY Effect|nmod|treatment END_ENTITY|nsubj|Effect	Effect of short term treatment of L-carnitine on tissue ACE activity in streptozotocin-induced diabetic rats .
23139833	0	L-carnitine	0,11	HDAC	29,33	L-carnitine	HDAC	MESH:D002331	9734	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|compound|END_ENTITY	L-carnitine is an endogenous HDAC inhibitor selectively inhibiting cancer cell growth in vivo and in vitro .
17432542	0	L-carnitine	131,142	HSP70	27,32	L-carnitine	HSP70	MESH:D002331	266759(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY expression|dep|role expression|nmod|END_ENTITY	Differential expression of HSP70 and ultrastructure of heart and liver tissues of rats treated with adriamycin : protective role of L-carnitine .
15877203	0	L-carnitine	0,11	MCAD	82,86	L-carnitine	MCAD	MESH:D002331	34	Chemical	Gene	tolerance|amod|START_ENTITY tolerance|appos|END_ENTITY	L-carnitine and exercise tolerance in medium-chain acyl-coenzyme_A_dehydrogenase _ -LRB- MCAD -RRB- _ deficiency : a pilot study .
11406104	0	L-carnitine	27,38	OCTN2	79,84	L-carnitine	OCTN2	MESH:D002331	6584	Chemical	Gene	transport|nmod|START_ENTITY transport|nmod|END_ENTITY	Na -LRB- + -RRB- - coupled transport of L-carnitine via high-affinity carnitine transporter OCTN2 and its subcellular localization in kidney .
11739607	0	L-carnitine	77,88	OCTN2	46,51	L-carnitine	OCTN2	MESH:D002331	29726(Tax:10116)	Chemical	Gene	distribution|nmod|START_ENTITY END_ENTITY|nmod|distribution	Functional relevance of carnitine transporter OCTN2 to brain distribution of L-carnitine and acetyl-L-carnitine across the blood-brain barrier .
24986327	0	L-carnitine	104,115	P53	0,3	L-carnitine	P53	MESH:D002331	301300(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	P53 , Bcl-2 and CD68 expression in response to amethopterin-induced lung_injury and ameliorating role of L-carnitine .
18194084	0	L-carnitine	36,47	acetylcholinesterase	92,112	L-carnitine	acetylcholinesterase	MESH:D002331	43	Chemical	Gene	supplementation|amod|START_ENTITY supplementation|nmod|END_ENTITY	The in vivo and in vitro effects of L-carnitine supplementation on the erythrocyte membrane acetylcholinesterase , Na + , K + - ATPase and Mg2 + - ATPase activities in basketball players .
11095004	0	L-carnitine	5,16	erythropoietin	35,49	L-carnitine	erythropoietin	MESH:D002331	2056	Chemical	Gene	decrease|nsubj|START_ENTITY decrease|dobj|requirement requirement|compound|END_ENTITY	Oral L-carnitine does not decrease erythropoietin requirement in pediatric dialysis .
11114574	0	L-carnitine	11,22	erythropoietin	77,91	L-carnitine	erythropoietin	MESH:D002331	2056	Chemical	Gene	Effects|nmod|START_ENTITY supplementation|nsubj|Effects supplementation|nmod|END_ENTITY	Effects of L-carnitine supplementation on renal_anemia in poor responders to erythropoietin .
1436358	0	L-carnitine	23,34	erythropoietin	72,86	L-carnitine	erythropoietin	MESH:D002331	2056	Chemical	Gene	START_ENTITY|nmod|response response|nmod|END_ENTITY	Effect of low doses of L-carnitine on the response to recombinant human erythropoietin in hemodialyzed children : about two cases .
21901057	0	L-carnitine	10,21	erythropoietin	45,59	L-carnitine	erythropoietin	MESH:D002331	2056	Chemical	Gene	administration|amod|START_ENTITY reduces|nsubj|administration reduces|xcomp|minor minor|nsubj|resistance resistance|compound|END_ENTITY	Long-term L-carnitine administration reduces erythropoietin resistance in chronic hemodialysis patients with thalassemia minor .
7485128	0	L-carnitine	0,11	erythropoietin	68,82	L-carnitine	erythropoietin	MESH:D002331	2056	Chemical	Gene	effects|amod|START_ENTITY treated|nsubj|effects treated|nmod|END_ENTITY	L-carnitine effects on anemia in hemodialyzed patients treated with erythropoietin .
15591012	0	L-carnitine	22,33	glucocorticoid_receptor	37,60	L-carnitine	glucocorticoid receptor	MESH:D002331	2908	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activity activity|compound|END_ENTITY	Modulatory effects of L-carnitine on glucocorticoid_receptor activity .
12003327	0	L-carnitine	8,19	insulin-like_growth_factor-I	37,65	L-carnitine	insulin-like growth factor-I	MESH:D002331	3479	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|concentration concentration|compound|END_ENTITY	Dietary L-carnitine increases plasma insulin-like_growth_factor-I concentration in chicks fed a diet with adequate dietary protein level .
18930039	0	L-carnitine	11,22	myoglobin	43,52	L-carnitine	myoglobin	MESH:D002331	4151	Chemical	Gene	Serum|dobj|START_ENTITY Serum|nmod|association association|nmod|END_ENTITY	Serum free L-carnitine in association with myoglobin as a diagnostic marker of acute_myocardial_infarction .
8820505	0	L-carnitine	15,26	myoglobin	36,45	L-carnitine	myoglobin	MESH:D002331	4151	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of oral L-carnitine on serum myoglobin in hemodialysis patients .
22435679	0	L-carnitine	11,22	peroxisome_proliferator-activated_receptor_alpha	85,133	L-carnitine	peroxisome proliferator-activated receptor alpha	MESH:D002331	5465	Chemical	Gene	Effects|nmod|START_ENTITY Effects|dep|involvement involvement|nmod|END_ENTITY	Effects of L-carnitine against oxidative stress in human hepatocytes : involvement of peroxisome_proliferator-activated_receptor_alpha .
17601992	0	L-carnosine	0,11	carnosinase-1	28,41	L-carnosine	carnosinase-1	null	84735	Chemical	Gene	START_ENTITY|appos|substrate substrate|nmod|END_ENTITY	L-carnosine , a substrate of carnosinase-1 , influences glucose metabolism .
18584487	0	L-carnosine	0,11	nm23-H1	144,151	L-carnosine	nm23-H1	null	4830	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	L-carnosine inhibits metastasis of SK-Hep-1 cells by inhibition of matrix metaoproteinase-9 expression and induction of an antimetastatic gene , nm23-H1 .
23454231	0	L-carnosine	0,11	signal_transducer_and_activator_of_transcription_3	53,103	L-carnosine	signal transducer and activator of transcription 3	null	25125(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	L-carnosine inhibits neuronal cell apoptosis through signal_transducer_and_activator_of_transcription_3 signaling pathway after acute focal cerebral_ischemia .
24611509	0	L-carvone	0,9	p53	18,21	L-carvone	p53	CHEBI:15400	7157	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	L-carvone induces p53 , caspase_3 mediated apoptosis and inhibits the migration of breast_cancer cell lines .
17524640	0	L-cysteine	39,49	Eg5	81,84	L-cysteine	Eg5	MESH:D003545	3832	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Synthesis and biological evaluation of L-cysteine derivatives as mitotic kinesin Eg5 inhibitors .
838265	0	L-cysteine	17,27	Oxytocinase	44,55	L-cysteine	Oxytocinase	MESH:D003545	4012	Chemical	Gene	aminopeptidase|amod|START_ENTITY aminopeptidase|appos|END_ENTITY	-LSB- The activity of L-cysteine aminopeptidase -LRB- Oxytocinase -RRB- during premature_labour and tocolytic treatment -LRB- author 's transl -RRB- -RSB- .
10542068	0	L-cysteine	97,107	acetyltransferase	76,93	L-cysteine	acetyltransferase	MESH:D003545	20468107	Chemical	Gene	required|nmod|START_ENTITY required|nmod|inhibition inhibition|nmod|END_ENTITY	Determination of the sites required for the allosteric inhibition of serine acetyltransferase by L-cysteine in plants .
10719747	0	L-cysteine	24,34	mucin	78,83	L-cysteine	mucin	MESH:D003545	65202(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Augmentative effects of L-cysteine and methylmethionine_sulfonium_chloride on mucin secretion in rabbit gastric mucous cells .
10343976	0	L-deprenyl	0,10	L-amino_acid_decarboxylase	28,54	L-deprenyl	L-amino acid decarboxylase	MESH:D012642	24311(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|mRNA mRNA|compound|END_ENTITY	L-deprenyl induces aromatic L-amino_acid_decarboxylase -LRB- AADC -RRB- mRNA in the rat substantia nigra and ventral tegmentum .
6793694	0	L-deprenyl	11,21	growth_hormone	31,45	L-deprenyl	growth hormone	MESH:D012642	2688	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of L-deprenyl on human growth_hormone secretion .
4042254	0	L-dihexanoylphosphatidylcholine	102,133	phospholipase_A2	71,87	L-dihexanoylphosphatidylcholine	phospholipase A2	null	151056	Chemical	Gene	hydrolysis|nmod|START_ENTITY hydrolysis|amod|END_ENTITY	D-dihexanoylphosphatidylcholine is not a pure competitive inhibitor of phospholipase_A2 hydrolysis of L-dihexanoylphosphatidylcholine .
15180924	0	L-dihydroxyphenylalanine	23,47	rBAT	94,98	L-dihydroxyphenylalanine	rBAT	null	29725(Tax:10116)	Chemical	Gene	transported|nsubjpass|START_ENTITY transported|nmod|END_ENTITY	The dopamine precursor L-dihydroxyphenylalanine is transported by the amino_acid transporters rBAT and LAT2 in renal cortex .
1549240	0	L-dopa	59,65	Catechol-O-methyltransferase	0,28	L-dopa	Catechol-O-methyltransferase	MESH:D007980	24267(Tax:10116)	Chemical	Gene	striatal|dobj|START_ENTITY striatal|nsubj|increases increases|amod|END_ENTITY	Catechol-O-methyltransferase inhibition increases striatal L-dopa and dopamine : an in vivo study in rats .
1255091	0	L-dopa	31,37	Prolactin	0,9	L-dopa	Prolactin	MESH:D007980	24683(Tax:10116)	Chemical	Gene	test|nmod|START_ENTITY test|compound|END_ENTITY	Prolactin inhibition test with L-dopa : decrease and restoration of plasma prolactin levels in the rat by a peripheral process .
21771855	0	L-dopa	53,59	Vascular_endothelial_growth_factor	0,34	L-dopa	Vascular endothelial growth factor	MESH:D007980	7422	Chemical	Gene	upregulated|nmod|START_ENTITY upregulated|nsubjpass|END_ENTITY	Vascular_endothelial_growth_factor is upregulated by L-dopa in the parkinsonian brain : implications for the development of dyskinesia .
7737328	0	L-dopa	96,102	catechol-O-methyltransferase	30,58	L-dopa	catechol-O-methyltransferase	MESH:D007980	24267(Tax:10116)	Chemical	Gene	metabolism|nmod|START_ENTITY Effects|nmod|metabolism Effects|nmod|tolcapone tolcapone|appos|inhibitor inhibitor|amod|END_ENTITY	Effects of tolcapone , a novel catechol-O-methyltransferase inhibitor , on striatal metabolism of L-dopa and dopamine in rats .
1903481	0	L-dopa	48,54	tyrosinase	23,33	L-dopa	tyrosinase	MESH:D007980	7299	Chemical	Gene	mechanism|nmod|START_ENTITY mechanism|nmod|regulation regulation|amod|END_ENTITY	Molecular mechanism of tyrosinase regulation by L-dopa in hamster melanoma cells .
8112501	0	L-dopa	21,27	tyrosinase	62,72	L-dopa	tyrosinase	MESH:D007980	308800(Tax:10116)	Chemical	Gene	levels|amod|START_ENTITY increase|nmod|levels increase|nmod|END_ENTITY	Specific increase of L-dopa levels in plasma upon infusion of tyrosinase containing liposomes .
778710	0	L-dopa_and_clomiphene_citrate	14,43	luteinizing_hormone-releasing_factor	75,111	L-dopa and clomiphene citrate	luteinizing hormone-releasing factor	null	153222	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of L-dopa_and_clomiphene_citrate on peripheral plasma levels of luteinizing_hormone-releasing_factor .
9508791	0	L-glutamate	60,71	Dip5p	0,5	L-glutamate	Dip5p	CHEBI:29985	855863(Tax:4932)	Chemical	Gene	transport|nmod|START_ENTITY mediates|dobj|transport mediates|nsubj|END_ENTITY	Dip5p mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate in Saccharomyces_cerevisiae .
10087511	0	L-glutamate	4,15	EAAT1	36,41	L-glutamate	EAAT1	CHEBI:29985	29483(Tax:10116)	Chemical	Gene	GLAST|amod|START_ENTITY GLAST|appos|END_ENTITY	The L-glutamate transporters GLAST -LRB- EAAT1 -RRB- and GLT-1 -LRB- EAAT2 -RRB- : expression and regulation in rat lactating mammary gland .
8531222	0	L-glutamate/L-aspartate	15,38	GLAST	52,57	L-glutamate/L-aspartate	GLAST	null	29483(Tax:10116)	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Coincidence of L-glutamate/L-aspartate _ transporter -LRB- GLAST -RRB- and glutamine_synthetase -LRB- GS -RRB- immunoreactions in retinal glia : evidence for coupling of GLAST and GS in transmitter clearance .
9450691	0	L-glutamate/L-aspartate	130,153	GLAST	167,172	L-glutamate/L-aspartate	GLAST	null	398856(Tax:8355)	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Inhibitory activity of a naturally occurring heterocyclic beta-substituted alanine , beta - -LRB- isoxazolin-5-on-4-yl -RRB- - L-alanine , on the L-glutamate/L-aspartate _ transporter -LRB- GLAST -RRB- expressed in Xenopus oocytes .
23466488	0	L-glutamine	5,16	GLP-1	34,39	L-glutamine	GLP-1	CHEBI:18050	24952(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|secretion secretion|amod|END_ENTITY	Oral L-glutamine increases active GLP-1 -LRB- 7-36 -RRB- amide secretion and improves glycemic control in stretpozotocin-nicotinamide induced diabetic rats .
3536706	0	L-glutamine	21,32	insulin	107,114	L-glutamine	insulin	CHEBI:18050	3630	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|secretion secretion|compound|END_ENTITY	Protective effect of L-glutamine against the inhibitory action of 2-cyclohexene-1-one upon Ba2 + - stimulated insulin secretion .
20448142	0	L-glutamine	24,35	leptin	8,14	L-glutamine	leptin	CHEBI:18050	25608(Tax:10116)	Chemical	Gene	transport|amod|START_ENTITY inhibits|dobj|transport inhibits|nsubj|END_ENTITY	Luminal leptin inhibits L-glutamine transport in rat small intestine : involvement of ASCT2 and B0AT1 .
7518015	0	L-homoarginine	50,64	intestinal_alkaline_phosphatase	15,46	L-homoarginine	intestinal alkaline phosphatase	CHEBI:27747	248	Chemical	Gene	Sensitivity|nmod|START_ENTITY Sensitivity|nmod|END_ENTITY	Sensitivity of intestinal_alkaline_phosphatase to L-homoarginine and its regulation by subunit-subunit interaction .
1478665	0	L-isoaspartyl/D-aspartyl	4,28	PCMT1	61,66	L-isoaspartyl/D-aspartyl	PCMT1	null	5110	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The L-isoaspartyl/D-aspartyl protein methyltransferase gene -LRB- PCMT1 -RRB- maps to human chromosome 6q22.3-6q24 and the syntenic region of mouse chromosome 10 .
1497671	0	L-lactate	49,58	epsilon-crystallin	25,43	L-lactate	epsilon-crystallin	CHEBI:16651	101801152	Chemical	Gene	activity|amod|START_ENTITY END_ENTITY|nmod|activity	Kinetic analysis of duck epsilon-crystallin with L-lactate dehydrogenase activity : determination of kinetic constants and comparison of substrate specificity .
26729373	0	L-leucine	44,53	mTORC1	69,75	L-leucine	mTORC1	CHEBI:15603	382056(Tax:10090)	Chemical	Gene	stimulation|amod|START_ENTITY stimulation|nmod|END_ENTITY	Improved transcription and translation with L-leucine stimulation of mTORC1 in Roberts_syndrome .
22210321	0	L-leucine	0,9	mTor	72,76	L-leucine	mTor	CHEBI:15603	21977(Tax:10090)	Chemical	Gene	alters|nsubj|START_ENTITY alters|nmod|END_ENTITY	L-leucine alters pancreatic b-cell differentiation and function via the mTor signaling pathway .
8745065	0	L-leucine	25,34	motilin	10,17	L-leucine	motilin	CHEBI:15603	100009276(Tax:9986)	Chemical	Gene	transport|amod|START_ENTITY Effect|nmod|transport Effect|nmod|END_ENTITY	Effect of motilin on the L-leucine transport in rabbit jejunum .
6416254	0	L-leucinthiol	0,13	aminopeptidase	46,60	L-leucinthiol	aminopeptidase	null	10404	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	L-leucinthiol - a potent inhibitor of leucine aminopeptidase .
3111463	0	L-lysinethiol	0,13	aminopeptidase_B	43,59	L-lysinethiol	aminopeptidase B	null	6051	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	L-lysinethiol : a subnanomolar inhibitor of aminopeptidase_B .
11824623	0	L-methionine	182,194	GMP	126,129	L-methionine	GMP	MESH:D008715	22978	Chemical	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	Application of capillary electrophoresis-mass spectrometry for the investigation of the binding behavior of oxaliplatin to 5 ' - GMP in the presence of the sulfur-containing amino_acid L-methionine .
24786562	0	L-mimosine	0,10	vascular_endothelial_growth_factor	39,73	L-mimosine	vascular endothelial growth factor	CHEBI:29063	7422	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|production production|nmod|END_ENTITY	L-mimosine increases the production of vascular_endothelial_growth_factor in human tooth slice organ culture model .
9618932	0	L-phenylalanine	0,15	acetylcholinesterase	36,56	L-phenylalanine	acetylcholinesterase	CHEBI:58095	83817(Tax:10116)	Chemical	Gene	effect|amod|START_ENTITY effect|nmod|END_ENTITY	L-phenylalanine effect on rat brain acetylcholinesterase and Na + , K -LRB- + -RRB- - ATPase .
9933971	0	L-phenylalanine	0,15	acetylcholinesterase	40,60	L-phenylalanine	acetylcholinesterase	CHEBI:58095	83817(Tax:10116)	Chemical	Gene	effect|amod|START_ENTITY effect|nmod|END_ENTITY	L-phenylalanine effect on rat diaphragm acetylcholinesterase and Na + , K -LRB- + -RRB- - ATPase .
12056888	0	L-phenylalanine	0,15	phenylalanine_hydroxylase	57,82	L-phenylalanine	phenylalanine hydroxylase	CHEBI:58095	5053	Chemical	Gene	binding|amod|START_ENTITY binding|nmod|END_ENTITY	L-phenylalanine binding and domain organization in human phenylalanine_hydroxylase : a differential scanning calorimetry study .
22711289	0	L-proline	13,22	PAT2	68,72	L-proline	PAT2	CHEBI:60039	246049(Tax:10090)	Chemical	Gene	Transport|nmod|START_ENTITY Transport|nmod|END_ENTITY	Transport of L-proline by the proton-coupled amino_acid transporter PAT2 in differentiated 3T3-L1 cells .
12893300	0	L-proline	70,79	tyrosinase	40,50	L-proline	tyrosinase	CHEBI:60039	7299	Chemical	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	Catalytic oxidation of acetaminophen by tyrosinase in the presence of L-proline : a kinetic study .
5465	0	L-prolyl-L-leucyl-glycine_amide	13,44	growth_hormone	48,62	L-prolyl-L-leucyl-glycine amide	growth hormone	null	2688	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|secretion secretion|amod|END_ENTITY	Influence of L-prolyl-L-leucyl-glycine_amide on growth_hormone secretion in normal and acromegalic subjects .
11055895	0	L-serine	125,133	3-phosphoglycerate_dehydrogenase	30,62	L-serine	3-phosphoglycerate dehydrogenase	CHEBI:33384	26227	Chemical	Gene	biosynthesis|amod|START_ENTITY associated|nmod|biosynthesis neurometabolic_disorder|acl|associated characterization|dep|neurometabolic_disorder characterization|nmod|deficiency deficiency|amod|END_ENTITY	Molecular characterization of 3-phosphoglycerate_dehydrogenase deficiency -- a neurometabolic_disorder associated with reduced L-serine biosynthesis .
17510490	0	L-serine	42,50	3-phosphoglycerate_dehydrogenase	71,103	L-serine	3-phosphoglycerate dehydrogenase	CHEBI:33384	236539(Tax:10090)	Chemical	Gene	enzyme|amod|START_ENTITY enzyme|amod|END_ENTITY	Segmental and complementary expression of L-serine biosynthetic enzyme 3-phosphoglycerate_dehydrogenase and neutral amino_acid transporter ASCT1 in the mouse kidney .
18751891	0	L-serine	14,22	3-phosphoglycerate_dehydrogenase	43,75	L-serine	3-phosphoglycerate dehydrogenase	CHEBI:33384	236539(Tax:10090)	Chemical	Gene	enzyme|amod|START_ENTITY enzyme|amod|END_ENTITY	Expression of L-serine biosynthetic enzyme 3-phosphoglycerate_dehydrogenase -LRB- Phgdh -RRB- and neutral amino_acid transporter ASCT1 following an excitotoxic lesion in the mouse hippocampus .
9708551	0	L-serine	22,30	3-phosphoglycerate_dehydrogenase	76,108	L-serine	3-phosphoglycerate dehydrogenase	CHEBI:33384	26227	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|management management|nmod|seizures seizures|nmod|deficiency deficiency|amod|END_ENTITY	Beneficial effects of L-serine and glycine in the management of seizures in 3-phosphoglycerate_dehydrogenase deficiency .
15641688	0	L-tetrahydropalmatine	11,32	bcl-2	55,60	L-tetrahydropalmatine	bcl-2	CHEBI:16563	24224(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expressions expressions|nmod|END_ENTITY	Effects of L-tetrahydropalmatine on the expressions of bcl-2 and bax in rat after acute global cerebral_ischemia and reperfusion .
1684912	0	L-threonine	32,43	ASC	66,69	L-threonine	ASC	CHEBI:16857	29108	Chemical	Gene	interaction|nmod|START_ENTITY END_ENTITY|nsubj|interaction	The preferential interaction of L-threonine with transport system ASC in cultured human fibroblasts .
11194708	0	L-thyroxine	86,97	TRH	69,72	L-thyroxine	TRH	MESH:D013974	7200	Chemical	Gene	treatment|amod|START_ENTITY restore|nmod|treatment restore|nmod|inhibited inhibited|compound|END_ENTITY	Pyridostigmine and metoclopramide do not restore the TSH response to TRH inhibited by L-thyroxine treatment in children with goiter .
1248450	0	L-thyroxine	14,25	growth_hormone	115,129	L-thyroxine	growth hormone	MESH:D013974	81668(Tax:10116)	Chemical	Gene	Conversion|nmod|START_ENTITY Conversion|nmod|L-thyroxine L-thyroxine|dep|measured measured|nmod|changes changes|nmod|END_ENTITY	Conversion of L-thyroxine to triiodo-L-thyronine and biological activity of L-thyroxine , as measured by changes in growth_hormone .
1248450	0	L-thyroxine	76,87	growth_hormone	115,129	L-thyroxine	growth hormone	MESH:D013974	81668(Tax:10116)	Chemical	Gene	START_ENTITY|dep|measured measured|nmod|changes changes|nmod|END_ENTITY	Conversion of L-thyroxine to triiodo-L-thyronine and biological activity of L-thyroxine , as measured by changes in growth_hormone .
15921183	0	L-thyroxine	80,91	growth_hormone	7,21	L-thyroxine	growth hormone	MESH:D013974	2688	Chemical	Gene	agonist|nmod|START_ENTITY agonist|nsubj|Use Use|nmod|END_ENTITY	Use of growth_hormone and gonadotropin_releasing_hormone agonist in addition to L-thyroxine to attain normal adult height in two patients with severe Hashimoto 's _ thyroiditis .
2989081	0	L-thyroxine	11,22	growth_hormone	33,47	L-thyroxine	growth hormone	MESH:D013974	2688	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of L-thyroxine and ovine growth_hormone on smoltification of amago salmon -LRB- Oncorhynchus rhodurus -RRB- .
49266	0	L-thyroxine	39,50	growth_hormone	78,92	L-thyroxine	growth hormone	MESH:D013974	81668(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Rapid effects of single small doses of L-thyroxine and triiodo-L-thyronine on growth_hormone , as studied in the rat by radioimmunoassy .
939463	0	L-thyroxine	89,100	growth_hormone	20,34	L-thyroxine	growth hormone	MESH:D013974	81668(Tax:10116)	Chemical	Gene	doses|nmod|START_ENTITY treated|nmod|doses rats|acl|treated content|nmod|rats END_ENTITY|xcomp|content	Decreased pituitary growth_hormone content in rats treated neonatally with high doses of L-thyroxine .
7143091	0	L-thyroxine	56,67	myoglobin	6,15	L-thyroxine	myoglobin	MESH:D013974	4151	Chemical	Gene	therapy|amod|START_ENTITY END_ENTITY|nmod|therapy	Serum myoglobin in primary hypothyroidism and effect of L-thyroxine therapy .
6159441	0	L-thyroxine	19,30	pancreatic_amylase	47,65	L-thyroxine	pancreatic amylase	MESH:D013974	497039(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Permissive role of L-thyroxine in induction of pancreatic_amylase by cortisol in neonatal rats .
23168675	0	L-trans-PDC	34,45	glutamate_transporter	63,84	L-trans-PDC	glutamate transporter	null	29483(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|inhibitor inhibitor|nmod|END_ENTITY	Supraspinal and spinal effects of L-trans-PDC , an inhibitor of glutamate_transporter , on the micturition reflex in rats .
447817	0	L-tryptophan	23,35	growth_hormone	64,78	L-tryptophan	growth hormone	CHEBI:16828	2688	Chemical	Gene	secretion|amod|START_ENTITY secretion|amod|END_ENTITY	Effect of melatonin on L-tryptophan - and apomorphine-stimulated growth_hormone secretion in man .
7208604	0	L-tryptophan	10,22	growth_hormone	46,60	L-tryptophan	growth hormone	CHEBI:16828	2688	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of L-tryptophan on apomorphine-induced growth_hormone secretion in normal subjects .
2411326	0	L-tryptophan	119,131	monoamine_oxidase-A	64,83	L-tryptophan	monoamine oxidase-A	CHEBI:16828	29253(Tax:10116)	Chemical	Gene	amiflamine|nmod|START_ENTITY amiflamine|nsubj|activity activity|nmod|rat rat|nmod|L-tryptophan L-tryptophan|nmod|inhibitor inhibitor|amod|END_ENTITY	Increased total activity in the rat after L-tryptophan plus the monoamine_oxidase-A inhibitor amiflamine but not after L-tryptophan plus clorgyline .
2411326	0	L-tryptophan	42,54	monoamine_oxidase-A	64,83	L-tryptophan	monoamine oxidase-A	CHEBI:16828	29253(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|amod|END_ENTITY	Increased total activity in the rat after L-tryptophan plus the monoamine_oxidase-A inhibitor amiflamine but not after L-tryptophan plus clorgyline .
2006240	0	L-tryptophan	73,85	prolactin	19,28	L-tryptophan	prolactin	CHEBI:16828	5617	Chemical	Gene	decreases|nmod|START_ENTITY decreases|dobj|responses responses|compound|END_ENTITY	Pindolol decreases prolactin and growth_hormone responses to intravenous L-tryptophan .
2991963	0	L-tryptophan	45,57	prolactin	13,22	L-tryptophan	prolactin	CHEBI:16828	5617	Chemical	Gene	infusion|amod|START_ENTITY Responses|nmod|infusion Responses|nmod|END_ENTITY	Responses of prolactin and growth_hormone to L-tryptophan infusion : effects in normal subjects and schizophrenic patients receiving neuroleptics .
3016787	0	L-tryptophan	64,76	prolactin	22,31	L-tryptophan	prolactin	CHEBI:16828	5617	Chemical	Gene	enhances|nmod|START_ENTITY enhances|dobj|responses responses|compound|END_ENTITY	Clomipramine enhances prolactin and growth_hormone responses to L-tryptophan .
4541674	0	L-tryptophan	68,80	prolactin	21,30	L-tryptophan	prolactin	CHEBI:16828	5617	Chemical	Gene	infusion|nmod|START_ENTITY secretion|nmod|infusion secretion|nsubj|Stimulation Stimulation|nmod|END_ENTITY	Stimulation of human prolactin secretion by intravenous infusion of L-tryptophan .
591625	0	L-tryptophan	11,23	prolactin	37,46	L-tryptophan	prolactin	CHEBI:16828	5617	Chemical	Gene	Failure|nmod|START_ENTITY Failure|acl|stimulate stimulate|dobj|secretion secretion|compound|END_ENTITY	Failure of L-tryptophan to stimulate prolactin secretion in man .
6815695	0	L-tryptophan	17,29	prolactin	33,42	L-tryptophan	prolactin	CHEBI:16828	5617	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of IV L-tryptophan on prolactin , growth_hormone , and mood in healthy subjects .
467418	0	L-tryptophan	27,39	tryptophanyl-tRNA_synthetase	43,71	L-tryptophan	tryptophanyl-tRNA synthetase	CHEBI:16828	7453	Chemical	Gene	binding|nmod|START_ENTITY binding|acl|END_ENTITY	Anticooperative binding of L-tryptophan to tryptophanyl-tRNA_synthetase from beef pancreas .
2508784	0	L-tyrosine	0,10	MSH	58,61	L-tyrosine	MSH	CHEBI:17895	4488	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|END_ENTITY	L-tyrosine stimulates induction of tyrosinase activity by MSH and reduces cooperative interactions between MSH receptors in hamster melanoma cells .
23046746	0	L-tyrosine	0,10	acetylcholinesterase	36,56	L-tyrosine	acetylcholinesterase	CHEBI:17895	83817(Tax:10116)	Chemical	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	L-tyrosine administration increases acetylcholinesterase activity in rats .
23690230	0	L-tyrosine	46,56	nerve_growth_factor	60,79	L-tyrosine	nerve growth factor	CHEBI:17895	310738(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|compound|END_ENTITY	Effect of acute and chronic administration of L-tyrosine on nerve_growth_factor levels in rat brain .
1906010	0	L-tyrosine	0,10	tyrosinase	19,29	L-tyrosine	tyrosinase	CHEBI:17895	22173(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	L-tyrosine induces tyrosinase expression via a posttranscriptional mechanism .
25086898	0	L-tyrosine	52,62	tyrosinase	87,97	L-tyrosine	tyrosinase	CHEBI:17895	7299	Chemical	Gene	templated|nmod|START_ENTITY templated|nmod|END_ENTITY	Novel synthesis of gold nanoclusters templated with L-tyrosine for selective analyzing tyrosinase .
2508784	0	L-tyrosine	0,10	tyrosinase	35,45	L-tyrosine	tyrosinase	CHEBI:17895	7299	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|induction induction|nmod|activity activity|amod|END_ENTITY	L-tyrosine stimulates induction of tyrosinase activity by MSH and reduces cooperative interactions between MSH receptors in hamster melanoma cells .
25297374	0	L-tyrosine	93,103	tyrosinase	68,78	L-tyrosine	tyrosinase	CHEBI:17895	7299	Chemical	Gene	generated|nmod|START_ENTITY generated|nmod|reaction reaction|amod|END_ENTITY	Alleviation effect of arbutin on oxidative stress generated through tyrosinase reaction with L-tyrosine and L-DOPA .
1371960	0	L-tyrosine_phosphate	51,71	tyrosinase	13,23	L-tyrosine phosphate	tyrosinase	null	7299	Chemical	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	Induction of tyrosinase in human melanoma cells by L-tyrosine_phosphate and cytochalasin D. Pigmentation of RVH_421 human melanoma cells is induced when cell division is inhibited by cytochalasin D or L-tyrosine_phosphate .
2458681	0	L364	42,46	CCK	26,29	L364	CCK	null	25298(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	Characterization of a new CCK antagonist , L364 ,718 : in vitro and in vivo studies .
2452436	0	L364718	10,17	CCK	25,28	L364718	CCK	MESH:D020109	25298(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|antagonist antagonist|compound|END_ENTITY	Effect of L364718 , a new CCK antagonist , on amylase secretion in isolated rat pancreatic acini .
3441445	0	L364718	0,7	CCK	15,18	L364718	CCK	MESH:D020109	609547(Tax:9615)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	L364718 , a new CCK antagonist , inhibits biological actions of CCK in conscious dogs .
3441445	0	L364718	0,7	CCK	62,65	L364718	CCK	MESH:D020109	609547(Tax:9615)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|actions actions|nmod|END_ENTITY	L364718 , a new CCK antagonist , inhibits biological actions of CCK in conscious dogs .
21144278	0	L9981	115,120	GSK-3b	50,56	L9981	GSK-3b	null	2932	Chemical	Gene	-RSB-|compound|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- Effects of nm23-H1 point mutation on activity of GSK-3b in human high-metastatic large cell lung_cancer cell line L9981 -RSB- .
22040120	0	LA-12	40,45	retinol_binding_protein_4	54,79	LA-12	retinol binding protein 4	null	25703(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	The new platinum-based anticancer agent LA-12 induces retinol_binding_protein_4 in vivo .
8465478	0	LAK	34,37	IL2	28,31	LAK	IL2	null	3558	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|compound|END_ENTITY	Influence of immunotherapy -LRB- IL2 + LAK + inhibition of prostaglandin synthesis -RRB- on peripheral blood immune parameters and in vitro cytokine production in metastatic renal_cell_carcinoma .
14578462	0	LAQ824	30,36	Her-2	52,57	LAQ824	Her-2	MESH:C477361	2064	Chemical	Gene	down-regulates|compound|START_ENTITY END_ENTITY|nsubj|down-regulates	Histone deacetylase inhibitor LAQ824 down-regulates Her-2 and sensitizes human breast_cancer cells to trastuzumab , taxotere , gemcitabine , and epothilone_B .
24941071	0	LASSBio-1135	0,12	TRPV1	21,26	LASSBio-1135	TRPV1	null	100462763	Chemical	Gene	START_ENTITY|dep|antagonist antagonist|compound|END_ENTITY	LASSBio-1135 : a dual TRPV1 antagonist and anti-TNF-alpha compound orally effective in models of inflammatory and neuropathic_pain .
11248787	0	LB-30057	25,33	thrombin	61,69	LB-30057	thrombin	MESH:C116605	100009146(Tax:9986)	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|inhibitor inhibitor|compound|END_ENTITY	Antithrombotic effect of LB-30057 -LRB- CI-1028 -RRB- , a new synthetic thrombin inhibitor , in a rabbit model of thrombosis : comparison with inogatran .
12510842	0	LB30057	0,7	thrombin	73,81	LB30057	thrombin	MESH:C116605	2147	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|relaxation relaxation|acl|induced induced|nmod|END_ENTITY	LB30057 inhibits platelet_aggregation and vascular relaxation induced by thrombin .
12540960	0	LB30057	27,34	thrombin	63,71	LB30057	thrombin	MESH:C116605	2147	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Antithrombotic activity of LB30057 , a newly synthesized direct thrombin inhibitor .
12723936	0	LB30057	0,7	thrombin	36,44	LB30057	thrombin	MESH:C116605	29251(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	LB30057 , an orally effective direct thrombin inhibitor , prevents arterial and venous_thrombosis in rats and dogs .
9681152	0	LB30057	64,71	thrombin	44,52	LB30057	thrombin	MESH:C116605	2147	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Structural modification of an orally active thrombin inhibitor , LB30057 : replacement of the D-pocket-binding naphthyl moiety .
9871573	0	LB30057	13,20	thrombin	60,68	LB30057	thrombin	MESH:C116605	2147	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Discovery of LB30057 , a benzamidrazone-based selective oral thrombin inhibitor .
25673087	0	LB30870	54,61	thrombin	78,86	LB30870	thrombin	MESH:C476981	2147	Chemical	Gene	pharmacodynamics|nmod|START_ENTITY Pharmacokinetics|appos|pharmacodynamics Pharmacokinetics|appos|inhibitor inhibitor|compound|END_ENTITY	Pharmacokinetics , pharmacodynamics and food effect of LB30870 , a novel direct thrombin inhibitor , after single oral doses in healthy men .
19179889	0	LBH589	32,38	XIAP	53,57	LBH589	XIAP	MESH:C496932	331	Chemical	Gene	downregulates|compound|START_ENTITY END_ENTITY|nsubj|downregulates	A histone deacetylase inhibitor LBH589 downregulates XIAP in mesothelioma cell lines which is likely responsible for increased apoptosis with TRAIL .
19188154	0	LBH589	80,86	aurora_A	20,28	LBH589	aurora A	MESH:C496932	6790	Chemical	Gene	kinases|nmod|START_ENTITY kinases|compound|END_ENTITY	Dual degradation of aurora_A and B kinases by the histone deacetylase inhibitor LBH589 induces G2-M arrest and apoptosis of renal_cancer cells .
16537804	0	LBH589	93,99	tyrosine_kinase	26,41	LBH589	tyrosine kinase	MESH:C496932	7294	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|effects effects|nmod|END_ENTITY	Combined effects of novel tyrosine_kinase inhibitor AMN107 and histone deacetylase inhibitor LBH589 against Bcr-Abl-expressing human leukemia cells .
26722027	0	LC-0296	29,36	Sirtuin-3	8,17	LC-0296	Sirtuin-3	null	23410	Chemical	Gene	Inhibitor|appos|START_ENTITY Inhibitor|compound|END_ENTITY	A Novel Sirtuin-3 Inhibitor , LC-0296 , Inhibits Cell Survival and Proliferation , and Promotes Apoptosis of Head_and_Neck_Cancer Cells .
20002082	0	LC15-0444	41,50	dipeptidyl_peptidase_IV	60,83	LC15-0444	dipeptidyl peptidase IV	MESH:C534891	1803	Chemical	Gene	Pharmacokinetics|nmod|START_ENTITY END_ENTITY|nsubj|Pharmacokinetics	Pharmacokinetics and pharmacodynamics of LC15-0444 , a novel dipeptidyl_peptidase_IV inhibitor , after multiple dosing in healthy volunteers .
22192641	0	LC15-0444	92,101	dipeptidyl_peptidase_IV	58,81	LC15-0444	dipeptidyl peptidase IV	MESH:C534891	1803	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Evaluation of the pharmacokinetic interaction between the dipeptidyl_peptidase_IV inhibitor LC15-0444 and pioglitazone in healthy volunteers .
25808463	0	LCB03-0110	54,64	VEGFR-2	78,85	LCB03-0110	VEGFR-2	MESH:C571281	16542(Tax:10090)	Chemical	Gene	activity|nmod|START_ENTITY activity|nmod|END_ENTITY	Anti-angiogenic activity of thienopyridine derivative LCB03-0110 by targeting VEGFR-2 and JAK/STAT3 Signalling .
22085492	0	LCH-7749944	0,11	p21-activated_kinase_4	32,54	LCH-7749944	p21-activated kinase 4	MESH:C570630	10298	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	LCH-7749944 , a novel and potent p21-activated_kinase_4 inhibitor , suppresses proliferation and invasion in human gastric_cancer cells .
20837883	0	LCI699	37,43	Aldosterone_synthase	0,20	LCI699	Aldosterone synthase	MESH:C553306	1585	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Aldosterone_synthase inhibition with LCI699 : a proof-of-concept study in patients with primary_aldosteronism .
24976294	0	LCL161	37,43	IAP	23,26	LCL161	IAP	MESH:C574246	248	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|effects effects|nmod|END_ENTITY	Synergistic effects of IAP inhibitor LCL161 and paclitaxel on hepatocellular_carcinoma cells .
18768150	0	LCL385	16,22	BCL-2	39,44	LCL385	BCL-2	MESH:C539749	24224(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|compound|END_ENTITY	Anti-ceramidase LCL385 acutely reduces BCL-2 expression in the hippocampus but is not associated with an increase of learned helplessness in rats .
25411367	0	LDK1229	82,89	CB1	110,113	LDK1229	CB1	null	1268	Chemical	Gene	START_ENTITY|dep|agonist agonist|compound|END_ENTITY	-LRB- 4 - -LRB- Bis -LRB- 4-fluorophenyl -RRB- methyl -RRB- piperazin-1-yl -RRB- -LRB- cyclohexyl -RRB- methanone_hydrochloride -LRB- LDK1229 -RRB- : a new cannabinoid CB1 receptor inverse agonist from the class of benzhydryl_piperazine analogs .
15641790	0	LDS-751	15,22	P-glycoprotein	28,42	LDS-751	P-glycoprotein	MESH:C057718	5243	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of LDS-751 with P-glycoprotein and mapping of the location of the R drug binding site .
16229491	0	LDS-751	15,22	P-glycoprotein	46,60	LDS-751	P-glycoprotein	MESH:C057718	5243	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of LDS-751 and rhodamine_123 with P-glycoprotein : evidence for simultaneous binding of both drugs .
19818729	0	LDS-751	15,22	P-glycoprotein	53,67	LDS-751	P-glycoprotein	MESH:C057718	5243	Chemical	Gene	START_ENTITY|nmod|site site|nmod|END_ENTITY	Interaction of LDS-751 with the drug-binding site of P-glycoprotein : a Trp fluorescence steady-state and lifetime study .
9652412	0	LDS-751	13,20	P-glycoprotein	112,126	LDS-751	P-glycoprotein	MESH:C057718	5243	Chemical	Gene	Transport|nmod|START_ENTITY membrane|nsubj|Transport membrane|nmod|site site|nmod|END_ENTITY	Transport of LDS-751 from the cytoplasmic leaflet of the plasma membrane by the rhodamine-123-selective site of P-glycoprotein .
8564552	0	LEX032	22,28	serine_protease_inhibitor	50,75	LEX032	serine protease inhibitor	MESH:C095800	299282(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Beneficial effects of LEX032 , a novel recombinant serine_protease_inhibitor , in murine traumatic_shock .
15618295	0	LFA703	23,29	ICAM-1	101,107	LFA703	ICAM-1	MESH:C430123	3383	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Differential effect of LFA703 , pravastatin , and fluvastatin on production of IL-18 and expression of ICAM-1 and CD40 in human monocytes .
15618295	0	LFA703	23,29	IL-18	77,82	LFA703	IL-18	MESH:C430123	3606	Chemical	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	Differential effect of LFA703 , pravastatin , and fluvastatin on production of IL-18 and expression of ICAM-1 and CD40 in human monocytes .
15833882	0	LGD1069	44,51	cyclooxygenase-2	68,84	LGD1069	cyclooxygenase-2	MESH:C095105	5743	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	The retinoid_X_receptor-selective retinoid , LGD1069 , down-regulates cyclooxygenase-2 expression in human breast cells through transcription factor crosstalk : implications for molecular-based chemoprevention .
11520053	0	LL-Z1271alpha	0,13	interleukin-1beta	18,35	LL-Z1271alpha	interleukin-1beta	MESH:C013363	3553	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	LL-Z1271alpha : an interleukin-1beta production inhibitor .
22469483	0	LMP-420	0,7	TNF-a	40,45	LMP-420	TNF-a	MESH:C511928	21926(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	LMP-420 , a small molecular inhibitor of TNF-a , prolongs islet allograft survival by induction of suppressor_of_cytokine_signaling-1 : synergistic effect with cyclosporin-A .
21536655	0	LOX-PP	28,34	Hsp70	50,55	LOX-PP	Hsp70	null	3308	Chemical	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The Ras signaling inhibitor LOX-PP interacts with Hsp70 and c-Raf to reduce Erk activation and transformed phenotype of breast_cancer cells .
15618220	0	LPA	103,106	AKT/PKB	157,164	LPA	AKT/PKB	CHEBI:52288	207	Chemical	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Lysophosphatidic_acid -LRB- LPA -RRB- protects primary chronic_lymphocytic_leukemia cells from apoptosis through LPA receptor activation of the anti-apoptotic protein AKT/PKB .
15618220	0	LPA	23,26	AKT/PKB	157,164	LPA	AKT/PKB	CHEBI:52288	207	Chemical	Gene	Lysophosphatidic_acid|appos|START_ENTITY protects|nsubj|Lysophosphatidic_acid protects|nmod|activation activation|nmod|END_ENTITY	Lysophosphatidic_acid -LRB- LPA -RRB- protects primary chronic_lymphocytic_leukemia cells from apoptosis through LPA receptor activation of the anti-apoptotic protein AKT/PKB .
18261210	0	LPA	56,59	Autotaxin	0,9	LPA	Autotaxin	CHEBI:52288	18606(Tax:10090)	Chemical	Gene	lysophosphatidic_acid|appos|START_ENTITY enzyme|nmod|lysophosphatidic_acid END_ENTITY|appos|enzyme	Autotaxin , a synthetic enzyme of lysophosphatidic_acid -LRB- LPA -RRB- , mediates the induction of nerve-injured neuropathic_pain .
20495010	0	LPA	14,17	Autotaxin	0,9	LPA	Autotaxin	CHEBI:52288	5168	Chemical	Gene	enzyme|compound|START_ENTITY END_ENTITY|dep|enzyme	Autotaxin -- an LPA producing enzyme with diverse functions .
21971049	0	LPA	77,80	Autotaxin	0,9	LPA	Autotaxin	CHEBI:52288	100332039(Tax:7955)	Chemical	Gene	receptors|appos|START_ENTITY development|nmod|receptors regulates|dobj|development regulates|nsubj|END_ENTITY	Autotaxin regulates vascular development via multiple lysophosphatidic_acid -LRB- LPA -RRB- receptors in zebrafish .
22159277	0	LPA	0,3	DRA	26,29	LPA	DRA	CHEBI:52288	1811	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|transcription transcription|compound|END_ENTITY	LPA stimulates intestinal DRA gene transcription via LPA2 receptor , PI3K/AKT , and c-Fos-dependent pathway .
26299613	0	LPA	32,35	FOXM1	0,5	LPA	FOXM1	CHEBI:52288	2305	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	FOXM1 is a downstream target of LPA and YAP oncogenic signaling pathways in high grade serous ovarian_cancer .
20044439	0	LPA	0,3	IL-6	12,16	LPA	IL-6	CHEBI:52288	3569	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|secretion secretion|compound|END_ENTITY	LPA induces IL-6 secretion from aortic smooth muscle cells via an LPA1-regulated , PKC-dependent , and p38alpha-mediated pathway .
21430287	0	LPA	73,76	NHE3	92,96	LPA	NHE3	CHEBI:52288	105243(Tax:10090)	Chemical	Gene	stimulation|compound|START_ENTITY stimulation|nmod|END_ENTITY	NHERF2 is necessary for basal activity , second messenger inhibition , and LPA stimulation of NHE3 in mouse distal ileum .
17554559	0	LPA	100,103	autotaxin	160,169	LPA	autotaxin	CHEBI:52288	5168	Chemical	Gene	lysophosphatidic_acid|appos|START_ENTITY production|nmod|lysophosphatidic_acid contribute|nmod|production contribute|nmod|secretion secretion|nmod|END_ENTITY	Submucosal connective tissue-type mast cells contribute to the production of lysophosphatidic_acid -LRB- LPA -RRB- in the gastrointestinal tract through the secretion of autotaxin -LRB- ATX -RRB- / lysophospholipase_D -LRB- lysoPLD -RRB- .
18082408	0	LPA	51,54	autotaxin	58,67	LPA	autotaxin	CHEBI:52288	5168	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	alpha - _ and_beta-substituted_phosphonate analogs of LPA as autotaxin inhibitors .
20360563	0	LPA	68,71	autotaxin	32,41	LPA	autotaxin	CHEBI:52288	18606(Tax:10090)	Chemical	Gene	turnover|nmod|START_ENTITY reveals|dobj|turnover reveals|nsubj|inhibitor inhibitor|nmod|END_ENTITY	Boronic_acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation .
21289650	0	LPA	75,78	autotaxin	54,63	LPA	autotaxin	CHEBI:52288	5168	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Location , location , location : a crystal-clear view of autotaxin saturating LPA receptors .
23069371	0	LPA	284,287	autotaxin	36,45	LPA	autotaxin	CHEBI:52288	5168	Chemical	Gene	lysophosphatidic_acid|appos|START_ENTITY produce|dobj|lysophosphatidic_acid lysophospholipase|xcomp|produce pyrophosphatase/phosphodiesterase|dep|lysophospholipase pyrophosphatase/phosphodiesterase|nsubj|relationships relationships|nmod|END_ENTITY	Structure-function relationships of autotaxin , a secreted lysophospholipase D. Autotaxin -LRB- ATX or ENPP2 -RRB- is an ectonucleotide pyrophosphatase/phosphodiesterase -LRB- ENPP -RRB- that functions as a secreted lysophospholipase D to produce the multifunctional lipid mediator lysophosphatidic_acid -LRB- LPA -RRB- from more complex lysophospholipids .
23486563	0	LPA	0,3	p130Cas	38,45	LPA	p130Cas	CHEBI:52288	9564	Chemical	Gene	Stimulates|nsubj|START_ENTITY Stimulates|dobj|Phosphorylation Phosphorylation|nmod|END_ENTITY	LPA Stimulates the Phosphorylation of p130Cas via Gai2 in Ovarian_Cancer Cells .
18483305	0	LS104	0,5	JAK2	57,61	LS104	JAK2	MESH:C530802	3717	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	LS104 , a non-ATP-competitive small-molecule inhibitor of JAK2 , is potently inducing apoptosis in JAK2V617F-positive cells .
7589187	0	LSL_60101	0,9	glial_fibrillary_acidic_protein	63,94	LSL 60101	glial fibrillary acidic protein	MESH:C095677	24387(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|concentration concentration|compound|END_ENTITY	LSL_60101 , a selective ligand for imidazoline I2 receptors , on glial_fibrillary_acidic_protein concentration .
26051858	3	LTB4	398,402	BLT2	380,384	LTB4	BLT2	MESH:D007975	57260(Tax:10090)	Chemical	Gene	receptor|nmod|START_ENTITY receptor|compound|END_ENTITY	The low affinity BLT2 receptor for LTB4 may transduce additional pro-atherogenic signaling , but combined BLT1 and BLT2 receptor antagonism has not previously been explored in atherosclerosis .
26035589	0	LTB4	30,34	p38	73,76	LTB4	p38	MESH:D007975	81649(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|Phosphorylation Phosphorylation|compound|END_ENTITY	EETs Attenuate Ox-LDL-Induced LTB4 Production and Activity by Inhibiting p38 MAPK Phosphorylation and 5-LO/BLT1 Receptor Expression in Rat Pulmonary Arterial Endothelial Cells .
16868834	0	LU-135252	34,43	Endothelin-1	0,12	LU-135252	Endothelin-1	MESH:C107831	24323(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Endothelin-1 receptor antagonist -LRB- LU-135252 -RRB- improves the microcirculation and course of TNBS_colitis in rats .
10536675	0	LU_135252	124,133	ETA	99,102	LU 135252	ETA	MESH:C107831	397457(Tax:9823)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	Altered endothelin-1 binding following balloon angioplasty of pig coronary arteries : effect of the ETA receptor antagonist , LU_135252 .
11057440	0	LU_135252	152,161	endothelin_A_receptor	118,139	LU 135252	endothelin A receptor	MESH:C107831	24326(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	Improvement of renal_dysfunction in rats with chronic_heart_failure after myocardial_infarction by treatment with the endothelin_A_receptor antagonist , LU_135252 .
23487174	0	LX4211	0,6	SGLT1	113,118	LX4211	SGLT1	MESH:C575681	20537(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|advcl|reducing reducing|dobj|cotransporter_1 cotransporter_1|appos|END_ENTITY	LX4211 increases serum glucagon-like_peptide_1 and peptide_YY levels by reducing sodium/glucose _ cotransporter_1 -LRB- SGLT1 -RRB- - mediated absorption of intestinal glucose .
23630033	0	LX4211	54,60	SGLT1	82,87	LX4211	SGLT1	MESH:C575681	6523	Chemical	Gene	trial|nmod|START_ENTITY design|nmod|trial design|appos|inhibitor inhibitor|nmod|END_ENTITY	Study design and rationale of a dose-ranging trial of LX4211 , a dual inhibitor of SGLT1 and SGLT2 , in type 2 diabetes inadequately controlled on metformin monotherapy .
25216510	0	LX4211	67,73	SGLT1	95,100	LX4211	SGLT1	MESH:C575681	6523	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|nmod|END_ENTITY	Greater Dose-Ranging Effects on A1C Levels Than on Glucosuria With LX4211 , a Dual Inhibitor of SGLT1 and SGLT2 , in Patients With Type 2 Diabetes on Metformin Monotherapy .
23487174	0	LX4211	0,6	glucagon-like_peptide_1	23,46	LX4211	glucagon-like peptide 1	MESH:C575681	14526(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	LX4211 increases serum glucagon-like_peptide_1 and peptide_YY levels by reducing sodium/glucose _ cotransporter_1 -LRB- SGLT1 -RRB- - mediated absorption of intestinal glucose .
23911260	0	LX4211	11,17	glucagon-like_peptide_1	119,142	LX4211	glucagon-like peptide 1	MESH:C575681	2641	Chemical	Gene	Effects|nmod|START_ENTITY cotransporters|nsubj|Effects cotransporters|dobj|inhibitor inhibitor|nmod|END_ENTITY	Effects of LX4211 , a dual sodium-dependent glucose cotransporters 1 and 2 inhibitor , on postprandial glucose , insulin , glucagon-like_peptide_1 , and peptide tyrosine_tyrosine in a dose-timing study in healthy subjects .
18849442	0	LXA4	0,4	ZO-1	16,20	LXA4	ZO-1	MESH:C040527	7082	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	LXA4 stimulates ZO-1 expression and transepithelial electrical resistance in human airway epithelial -LRB- 16HBE14o - -RRB- cells .
15131758	0	LY117018	53,61	growth_hormone	65,79	LY117018	growth hormone	MESH:C025430	2688	Chemical	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	Effects of the selective estrogen receptor modulator LY117018 on growth_hormone secretion : In vitro studies .
2502794	0	LY134046	36,44	phenylethanolamine_N-methyltransferase	62,100	LY134046	phenylethanolamine N-methyltransferase	MESH:C028625	24661(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Activation in young rats induced by LY134046 , an inhibitor of phenylethanolamine_N-methyltransferase .
2962555	0	LY141865	51,59	specific_D-1_and_D-2	11,31	LY141865	specific D-1 and D-2	null	29484(Tax:10116)	Chemical	Gene	agonists|appos|START_ENTITY agonists|amod|END_ENTITY	Effects of specific_D-1_and_D-2 dopamine agonists -LRB- LY141865 and SKF-38393 -RRB- and pergolide on urinary output of rats .
2946929	0	LY195115	0,8	cyclic_nucleotide_phosphodiesterase	43,78	LY195115	cyclic nucleotide phosphodiesterase	MESH:C050325	5140	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	LY195115 : a potent , selective inhibitor of cyclic_nucleotide_phosphodiesterase located in the sarcoplasmic reticulum .
22006998	0	LY2109761	60,69	TGF-b	12,17	LY2109761	TGF-b	MESH:C530108	7040	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Blockade of TGF-b signaling by the TGFbR-I kinase inhibitor LY2109761 enhances radiation response and prolongs survival in glioblastoma .
16866524	0	LY2183240	47,56	FAAH	82,86	LY2183240	FAAH	MESH:C522826	2166	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases .
21251179	0	LY2189265	0,9	glucagon-like_peptide-1	25,48	LY2189265	glucagon-like peptide-1	null	2641	Chemical	Gene	START_ENTITY|appos|analogue analogue|amod|END_ENTITY	LY2189265 , a long-acting glucagon-like_peptide-1 analogue , showed a dose-dependent effect on insulin secretion in healthy subjects .
21251180	0	LY2189265	15,24	glucagon-like_peptide-1	40,63	LY2189265	glucagon-like peptide-1	null	2641	Chemical	Gene	START_ENTITY|appos|analogue analogue|amod|END_ENTITY	The effects of LY2189265 , a long-acting glucagon-like_peptide-1 analogue , in a randomized , placebo-controlled , double-blind study of overweight/obese patients with type 2 diabetes : the EGO study .
26581242	0	LY2228820_Dimesylate	76,96	p38	43,46	LY2228820 Dimesylate	p38	MESH:C580958	1432	Chemical	Gene	Study|appos|START_ENTITY Study|nmod|Inhibitor Inhibitor|compound|END_ENTITY	A First-in-Human Phase I Study of the Oral p38 MAPK Inhibitor , Ralimetinib -LRB- LY2228820_Dimesylate -RRB- , in Patients with Advanced_Cancer .
23335506	0	LY2228820_dimesylate	0,20	p38	47,50	LY2228820 dimesylate	p38	MESH:C580958	1432	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|kinase kinase|amod|END_ENTITY	LY2228820_dimesylate , a selective inhibitor of p38 mitogen-activated protein kinase , reduces angiogenic endothelial cord formation in vitro and in vivo .
24356814	0	LY2228820_dimesylate	20,40	p38	78,81	LY2228820 dimesylate	p38	MESH:C580958	26416(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Characterization of LY2228820_dimesylate , a potent and selective inhibitor of p38 MAPK with antitumor activity .
24727324	0	LY2510924	19,28	CXCR4	32,37	LY2510924	CXCR4	null	7852	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	A phase I trial of LY2510924 , a CXCR4 peptide antagonist , in patients with advanced_cancer .
25504752	0	LY2510924	18,27	CXCR4	52,57	LY2510924	CXCR4	null	7852	Chemical	Gene	START_ENTITY|appos|Antagonist Antagonist|compound|END_ENTITY	Identification of LY2510924 , a Novel Cyclic Peptide CXCR4 Antagonist That Exhibits Antitumor Activities in Solid Tumor and Breast Cancer Metastatic Models .
24752449	0	LY2523355	36,45	Eg5	63,66	LY2523355	Eg5	null	3832	Chemical	Gene	study|nmod|START_ENTITY study|appos|inhibitor inhibitor|amod|END_ENTITY	A phase 1 and dose-finding study of LY2523355 -LRB- litronesib -RRB- , an Eg5 inhibitor , in Japanese patients with advanced solid tumors .
26304237	0	LY2523355	23,32	Eg5	8,11	LY2523355	Eg5	null	3832	Chemical	Gene	Inhibitor|appos|START_ENTITY Inhibitor|compound|END_ENTITY	A Novel Eg5 Inhibitor -LRB- LY2523355 -RRB- Causes Mitotic_Arrest and Apoptosis in Cancer Cells and Shows Potent Antitumor Activity in Xenograft Tumor Models .
1316967	0	LY255283	41,49	Leukotriene_B4_receptor	0,23	LY255283	Leukotriene B4 receptor	MESH:C063823	1241	Chemical	Gene	series|compound|START_ENTITY antagonists|dep|series antagonists|amod|END_ENTITY	Leukotriene_B4_receptor antagonists : the LY255283 series of hydroxyacetophenones .
1329112	0	LY255283	82,90	leukotriene_B4_receptor	45,68	LY255283	leukotriene B4 receptor	MESH:C063823	1241	Chemical	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Flow cytometric evaluation of the effects of leukotriene_B4_receptor antagonists -LRB- LY255283 and SC-41930 -RRB- on calcium mobilization and integrin expression of activated human neutrophils .
1335877	0	LY255283	21,29	leukotriene_B4_receptor	33,56	LY255283	leukotriene B4 receptor	MESH:C063823	100379538(Tax:10141)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Pulmonary actions of LY255283 , a leukotriene_B4_receptor antagonist .
26288133	0	LY2603618	17,26	CHK1	30,34	LY2603618	CHK1	null	1111	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Phase I study of LY2603618 , a CHK1 inhibitor , in combination with gemcitabine in Japanese patients with solid tumors .
26612134	0	LY2603618	0,9	CHK1	23,27	LY2603618	CHK1	MESH:C582547	1111	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	LY2603618 , a selective CHK1 inhibitor , enhances the anti-tumor effect of gemcitabine in xenograft tumor models .
27044938	0	LY2606368	17,26	Checkpoint_Kinase_1	30,49	LY2606368	Checkpoint Kinase 1	null	1111	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|amod|END_ENTITY	Phase I Study of LY2606368 , a Checkpoint_Kinase_1 Inhibitor , in Patients With Advanced_Cancer .
26954567	0	LY2624587	23,32	CXCR4	14,19	LY2624587	CXCR4	null	7852	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of CXCR4 by LY2624587 , a Fully Humanized Anti-CXCR4 Antibody Induces Apoptosis of Hematologic_Malignancies .
2366187	0	LY277359_maleate	0,16	5-HT3_receptor	41,55	LY277359 maleate	5-HT3 receptor	MESH:C064877	79246(Tax:10116)	Chemical	Gene	START_ENTITY|dep|antagonist antagonist|amod|END_ENTITY	LY277359_maleate : a potent and selective 5-HT3_receptor antagonist without gastroprokinetic activity .
26757360	0	LY2801653	19,28	c-MET	10,15	LY2801653	c-MET	MESH:C586252	4233	Chemical	Gene	Targeting|nmod|START_ENTITY Targeting|dobj|END_ENTITY	Targeting c-MET by LY2801653 for treatment of cholangiocarcinoma .
7786309	0	LY293111	136,144	leukotriene_B4_receptor	155,178	LY293111	leukotriene B4 receptor	MESH:C094099	1241	Chemical	Gene	benzoic_acid|appos|START_ENTITY benzoic_acid|appos|antagonist antagonist|amod|END_ENTITY	Blockade of human neutrophil activation by 2 - -LSB- 2-propyl-3 - -LSB- 3 - -LSB- 2-ethyl-4 - -LRB- 4-fluorophenyl -RRB- -5 - _ hydroxyphenoxy -RSB- propoxy -RSB- phenoxy -RSB- benzoic_acid -LRB- LY293111 -RRB- , a novel leukotriene_B4_receptor antagonist .
8994512	0	LY293111	48,56	leukotriene_B4_receptor	12,35	LY293111	leukotriene B4 receptor	MESH:C094099	1241	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Effect of a leukotriene_B4_receptor antagonist , LY293111 , on allergen induced responses in asthma .
11339501	0	LY293111Na	47,57	leukotriene_B4_receptor	11,34	LY293111Na	leukotriene B4 receptor	null	100379538(Tax:10141)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Effects of leukotriene_B4_receptor antagonist , LY293111Na , on antigen-induced bronchial_hyperresponsiveness and leukocyte infiltration in sensitized guinea_pigs .
8613940	0	LY293111Na	15,25	leukotriene_B4_receptor	29,52	LY293111Na	leukotriene B4 receptor	null	716055(Tax:9544)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	The effects of LY293111Na , a leukotriene_B4_receptor antagonist , on the pulmonary_neutrophilia and CD11b expression caused by inhalation of a leukotriene B4 aerosol in rhesus_monkeys .
16489044	0	LY294002	87,95	Activating_transcription_factor_3	0,33	LY294002	Activating transcription factor 3	MESH:C085911	467	Chemical	Gene	targets|nmod|START_ENTITY targets|nsubj|END_ENTITY	Activating_transcription_factor_3 and early_growth_response_1 are the novel targets of LY294002 in a phosphatidylinositol_3-kinase-independent pathway .
18657281	0	LY294002	0,8	COX-2	41,46	LY294002	COX-2	MESH:C085911	4513	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	LY294002 inhibits glucocorticoid-induced COX-2 gene expression in cardiomyocytes through a phosphatidylinositol_3_kinase-independent mechanism .
20446020	4	LY294002	657,665	COX-2	848,853	LY294002	COX-2	MESH:C085911	5743	Chemical	Gene	inhibitors|nmod|START_ENTITY administration|nmod|inhibitors found|nmod|administration found|dobj|END_ENTITY	After administration of inhibitors including LY294002 -LRB- Akt activation inhibitor -RRB- , U0126 -LRB- ERK1/2 inhibitor -RRB- , SB203580 -LRB- p38 MAPK inhibitor -RRB- , SP600125 -LRB- JNK1/2 inhibitor -RRB- , or QNZ -LRB- NFkappaB inhibitor -RRB- , we found that PGE2 treatment increases COX-2 via Akt and ERK1/2 pathways , thus promoting cellular motility in human LoVo_cancer cells .
22285490	0	LY294002	0,8	IFN-b	34,39	LY294002	IFN-b	MESH:C085911	3456	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	LY294002 inhibits TLR3/4-mediated IFN-b production via inhibition of IRF3 activation with a PI3K-independent mechanism .
16773206	0	LY294002	0,8	PI-3K	26,31	LY294002	PI-3K	MESH:C085911	5293	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	LY294002 , an inhibitor of PI-3K , enhances heat_sensitivity independently of p53 status in human lung_cancer cells .
18423117	0	LY294002	48,56	PI-3K	20,25	LY294002	PI-3K	MESH:C085911	5293	Chemical	Gene	Akt|dobj|START_ENTITY effect|parataxis|Akt effect|nmod|END_ENTITY	-LSB- Reversal effect of PI-3K / Akt pathway inhibitor LY294002 on multidrug resistance of ovarian_cancer cell line A2780/Taxol -RSB- .
10686085	10	LY294002	1387,1395	PI3K	1370,1374	LY294002	GDNF	MESH:C085911	2668	Chemical	Gene	inhibitors|appos|START_ENTITY inhibitors|nummod|END_ENTITY	Similarly , the specific PI3K inhibitors , LY294002 and wortmannin , were able to inhibit the promotion of motor axon outgrowth by GDNF , but did not affect neuroprotective activity .
11854287	6	LY294002	1001,1009	PI3K	985,989	LY294002	PI3K	MESH:C085911	18708(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	The exposure of cells expressing exogenous TGase to the PI3K inhibitor , LY294002 , reduced the ability of TGase to be photoaffinity-labeled with -LSB- alpha - -LRB- 32 -RRB- P -RSB- GTP , providing evidence that PI3K regulates the GTP binding activity of TGase as well as its expression .
12788194	0	LY294002	95,103	PI3K	84,88	LY294002	PI3K	MESH:C085911	5293	Chemical	Gene	using|dobj|START_ENTITY sensitization|dep|using sensitization|acl|inhibiting inhibiting|dobj|activity activity|nmod|END_ENTITY	Radiation sensitization of human cancer cells in vivo by inhibiting the activity of PI3K using LY294002 .
21223717	0	LY294002	25,33	PI3K	10,14	LY294002	PI3K	MESH:C085911	5293	Chemical	Gene	START_ENTITY|dep|Study Study|nmod|END_ENTITY	-LSB- Study on PI3K inhibitor LY294002 for chemotherapeutic sensitization in diffuse large B cell lymphoma cell lines . -RSB-
23931732	0	LY294002	72,80	PI3K	53,57	LY294002	PI3K	MESH:C085911	842344(Tax:3702)	Chemical	Gene	coupled|nmod|START_ENTITY coupled|nmod|inhibition inhibition|compound|END_ENTITY	Vesicular trafficking and stress response coupled to PI3K inhibition by LY294002 as revealed by proteomic and cell biological analysis .
24072614	6	LY294002	1012,1020	PI3K	1053,1057	LY294002	PI3K	MESH:C085911	5293	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	We further show that LY294002 and Rapamycin , the inhibitor of PI3K and mTOR respectively , promote CVB3-induced CPE and apoptosis .
24244375	8	LY294002	1323,1331	PI3K	1333,1337	LY294002	PI3K	MESH:C085911	5293	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Pre-treatment with SC514 -LRB- NF-kB inhibitor -RRB- , LY294002 -LRB- PI3K inhibitor -RRB- , AG490 -LRB- JAK2 inhibitor -RRB- and Janex-1 -LRB- JAK3 inhibitor -RRB- showed partial reduction of the Tat-mediated induction of CCL5 suggesting involvement of JAK , PI3K/Akt and NF-kB in CCL5 expression .
25036402	8	LY294002	1486,1494	PI3K	1470,1474	LY294002	Jab1	MESH:C085911	10987	Chemical	Gene	START_ENTITY|amod|phosphatidylinositol_3-kinase phosphatidylinositol_3-kinase|dep|END_ENTITY	Treatment of phosphatidylinositol_3-kinase -LRB- PI3K -RRB- inhibitor LY294002 could diminish Jab1 expression but increase BRSK1 expression .
25929181	4	LY294002	690,698	PI3K	724,728	LY294002	IL-4	MESH:C085911	16189(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	LY294002 , a specific inhibitor of PI3K , was given intratracheally 1h before each challenge .
26639237	0	LY294002	29,37	PI3K	14,18	LY294002	PI3K	MESH:C085911	5293	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|effect effect|nmod|END_ENTITY	The effect of PI3K inhibitor LY294002 and gemcitabine_hydrochloride combined with ionizing radiation on the formation of vasculogenic mimicry of Panc-1 cells in vitro and in vivo .
15735908	0	LY294002	63,71	PKB/Akt	0,7	LY294002	PKB/Akt	MESH:C085911	207	Chemical	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	PKB/Akt mediates radiosensitization by the signaling inhibitor LY294002 in human malignant_gliomas .
16397049	0	LY294002	44,52	Phosphatidylinositol_3-kinase	0,29	LY294002	Phosphatidylinositol 3-kinase	MESH:C085911	5293	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Phosphatidylinositol_3-kinase inhibition by LY294002 radiosensitizes human cervical_cancer cell lines .
22240122	0	LY294002	24,32	inducible_nitric_oxide_synthase	51,82	LY294002	inducible nitric oxide synthase	MESH:C085911	4843	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|amod|END_ENTITY	Differential effects of LY294002 and wortmannin on inducible_nitric_oxide_synthase expression in glomerular mesangial cells .
14960322	0	LY294002	0,8	monocyte_chemoattractant_protein-1	18,52	LY294002	monocyte chemoattractant protein-1	MESH:C085911	6347	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	LY294002 inhibits monocyte_chemoattractant_protein-1 expression through a phosphatidylinositol_3-kinase-independent mechanism .
10741711	0	LY294002	103,111	phosphatidylinositol_3-kinase	62,91	LY294002	phosphatidylinositol 3-kinase	MESH:C085911	18708(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	In vivo and in vitro ovarian_carcinoma growth inhibition by a phosphatidylinositol_3-kinase inhibitor -LRB- LY294002 -RRB- .
15894110	0	LY294002	0,8	phosphatidylinositol_3-kinase	115,144	LY294002	phosphatidylinositol 3-kinase	MESH:C085911	18708(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|parataxis|mechanism mechanism|nmod|END_ENTITY	LY294002 inhibits LPS-induced NO production through a inhibition of NF-kappaB activation : independent mechanism of phosphatidylinositol_3-kinase .
23124851	0	LY294002	23,31	phosphatidylinositol_3-kinase	49,78	LY294002	phosphatidylinositol 3-kinase	MESH:C085911	298947(Tax:10116)	Chemical	Gene	treatment|nmod|START_ENTITY treatment|appos|inhibitor inhibitor|nmod|END_ENTITY	Chronic treatment with LY294002 , an inhibitor of phosphatidylinositol_3-kinase , attenuates ischemia/reperfusion-induced cardiac_dysfunction in normotensive and hypertensive diabetic animals .
16836907	0	LY294002	14,22	protein_kinase_B	26,42	LY294002	protein kinase B	MESH:C085911	2185	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|expression expression|amod|END_ENTITY	-LSB- Influence of LY294002 on protein_kinase_B expression in salivary adenoid_cystic_carcinoma -LRB- SACC -RRB- -83 and SACC-LM cells -RSB- .
17016665	0	LY294005	31,39	Akt	17,20	LY294005	Akt	MESH:C477931	207	Chemical	Gene	START_ENTITY|nsubj|Potential Potential|nmod|inhibitor inhibitor|compound|END_ENTITY	Potential of the Akt inhibitor LY294005 to antagonize the efficacy of Cisplatin against HCT116_tumor cells in a DNA mismatch repair-dependent manner .
14593497	0	LY317615	0,8	VEGF	26,30	LY317615	VEGF	null	7422	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|levels levels|compound|END_ENTITY	LY317615 decreases plasma VEGF levels in human tumor xenograft-bearing mice .
9435190	0	LY320135	0,8	CB1	30,33	LY320135	CB1	MESH:C110158	12801(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	LY320135 , a novel cannabinoid CB1 receptor antagonist , unmasks coupling of the CB1 receptor to stimulation of cAMP accumulation .
9435190	0	LY320135	0,8	CB1	79,82	LY320135	CB1	MESH:C110158	12801(Tax:10090)	Chemical	Gene	unmasks|nsubj|START_ENTITY unmasks|dobj|coupling coupling|nmod|receptor receptor|compound|END_ENTITY	LY320135 , a novel cannabinoid CB1 receptor antagonist , unmasks coupling of the CB1 receptor to stimulation of cAMP accumulation .
10937586	0	LY333531	20,28	PKC-beta	0,8	LY333531	PKC-beta	MESH:C099154	25023(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	PKC-beta inhibitor -LRB- LY333531 -RRB- attenuates leukocyte entrapment in retinal microcirculation of diabetic rats .
16891764	0	LY333531	32,40	intercellular_adhesion_molecule-1	52,85	LY333531	intercellular adhesion molecule-1	MESH:C099154	25464(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|amod|END_ENTITY	Protein kinase C beta inhibitor LY333531 attenuates intercellular_adhesion_molecule-1 and monocyte_chemotactic_protein-1 expression in the kidney in diabetic rats .
9641544	0	LY334370	62,70	5-HT1A	24,30	LY334370	5-HT1A	MESH:C108218	3350	Chemical	Gene	receptors|nmod|START_ENTITY receptors|nummod|END_ENTITY	G-protein activation at 5-HT1A receptors by the 5-ht1F ligand LY334370 in guinea-pig brain sections and recombinant cell lines .
12455064	0	LY335979	79,87	MRP1	37,41	LY335979	MRP1	MESH:C095179	8714	Chemical	Gene	resistance|nmod|START_ENTITY resistance|amod|END_ENTITY	Modulation of P-glycoprotein but not MRP1 - or BCRP-mediated drug resistance by LY335979 .
11172691	0	LY335979	66,74	P-glycoprotein	40,54	LY335979	P-glycoprotein	MESH:C095179	67078(Tax:10090)	Chemical	Gene	modulator|appos|START_ENTITY modulator|amod|END_ENTITY	Reversal of multidrug resistance by the P-glycoprotein modulator , LY335979 , from the bench to the clinic .
9849663	0	LY339434	0,8	GluR5	12,17	LY339434	GluR5	null	2897	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	LY339434 , a GluR5 kainate receptor agonist .
16023151	0	LY341495	78,86	mGlu2/3	158,165	LY341495	mGlu2/3	MESH:C114624	108069(Tax:10090)	Chemical	Gene	brain|nmod|START_ENTITY induction|nmod|brain Comparison|nmod|induction Comparison|dep|evidence evidence|nmod|tone tone|nmod|receptors receptors|amod|END_ENTITY	Comparison of c-Fos induction in the brain by the mGlu2/3 receptor antagonist LY341495 and agonist LY354740 : evidence for widespread endogenous tone at brain mGlu2/3 receptors in vivo .
16043198	0	LY341495	46,54	mGlu2/3	17,24	LY341495	mGlu2/3	MESH:C114624	108069(Tax:10090)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	The preferential mGlu2/3 receptor antagonist , LY341495 , reduces the frequency of spike-wave_discharges in the WAG/Rij rat model of absence_epilepsy .
11406193	0	LY392098	59,67	BDNF	14,18	LY392098	BDNF	MESH:C434043	627	Chemical	Gene	expression|nmod|START_ENTITY expression|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of BDNF expression in primary neuron culture by LY392098 , a novel AMPA receptor potentiator .
26341392	0	LY395756	0,8	mGluR2	13,19	LY395756	mGluR2	null	14800(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	LY395756 , an mGluR2 agonist and mGluR3 antagonist , enhances NMDA receptor expression and function in the normal adult rat prefrontal cortex , but fails to improve working memory and reverse MK801-induced working memory_impairment .
15682298	0	LY456236	153,161	mGluR1	134,140	LY456236	mGluR1	MESH:C504780	14799(Tax:10090)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	The antinociceptive and anxiolytic-like effects of the metabotropic glutamate receptor 5 -LRB- mGluR5 -RRB- antagonists , MPEP and MTEP , and the mGluR1 antagonist , LY456236 , in rodents : a comparison of efficacy and side-effect profiles .
17408408	0	LY517717	49,57	factor_Xa	29,38	LY517717	factor Xa	MESH:C507963	2159	Chemical	Gene	START_ENTITY|nsubj|study study|nmod|inhibitor inhibitor|compound|END_ENTITY	A phase II study of the oral factor_Xa inhibitor LY517717 for the prevention of venous_thromboembolism after hip or knee replacement .
21346003	0	LY654322	14,22	growth_hormone_secretagogue	26,53	LY654322	growth hormone secretagogue	MESH:C568909	403587(Tax:9615)	Chemical	Gene	Metabolism|nmod|START_ENTITY Metabolism|appos|END_ENTITY	Metabolism of LY654322 , a growth_hormone_secretagogue , to an unusual diimidazopyridine metabolite .
15447994	0	LY900003	22,30	protein_kinase_C-alpha	58,80	LY900003	protein kinase C-alpha	MESH:C108494	5578	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	A phase I/II study of LY900003 , an antisense inhibitor of protein_kinase_C-alpha , in combination with cisplatin and gemcitabine in patients with advanced non-small_cell_lung_cancer .
16133798	0	LY900003	43,51	protein_kinase_C-alpha	80,102	LY900003	protein kinase C-alpha	MESH:C108494	5578	Chemical	Gene	aprinocarsen|appos|START_ENTITY aprinocarsen|appos|inhibitor inhibitor|nmod|END_ENTITY	A phase I trial of aprinocarsen -LRB- ISIS_3521 / LY900003 -RRB- , an antisense inhibitor of protein_kinase_C-alpha administered as a 24-hour weekly infusion schedule in patients with advanced_cancer .
25528375	0	LYSOPHOSPHATIDIC_ACID	99,120	LYSOPHOSPHOLIPASE	124,141	LYSOPHOSPHATIDIC ACID	LYSOPHOSPHOLIPASE	MESH:C032881	5321	Chemical	Gene	ACTIVITY|compound|START_ENTITY ACTIVITY|compound|END_ENTITY	New Members of the Mammalian Glycerophosphodiester Phosphodiesterase Family : GDE4 AND GDE7 PRODUCE LYSOPHOSPHATIDIC_ACID BY LYSOPHOSPHOLIPASE D ACTIVITY .
3903538	0	LY_134046	140,149	phenylethanolamine_N-methyltransferase	154,192	LY 134046	phenylethanolamine N-methyltransferase	MESH:C028625	24661(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|nmod|END_ENTITY	Reduction of central epinephrine concentrations is consistent with the continued occurrence of ovulation in rats treated with an inhibitor -LRB- LY_134046 -RRB- of phenylethanolamine_N-methyltransferase .
1797560	0	LY_277359	32,41	5-HT3_receptor	55,69	LY 277359	5-HT3 receptor	MESH:C064877	79246(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|antagonist antagonist|amod|END_ENTITY	The effect of acute and chronic LY_277359 , a selective 5-HT3_receptor antagonist , on the number of spontaneously active midbrain dopamine neurons .
18836485	0	La	23,25	Akt	0,3	La	Akt	null	11651(Tax:10090)	Chemical	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Akt phosphorylation of La regulates specific mRNA translation in glial progenitors .
26786855	0	La0.5Sr0.5Mn1-xAxO3	67,86	CO2	155,158	La0.5Sr0.5Mn1-xAxO3	CO2	null	717	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Beneficial effects of substituting trivalent ions in the B-site of La0.5Sr0.5Mn1-xAxO3 -LRB- A = Al , Ga , Sc -RRB- on the thermochemical generation of CO and H2 from CO2 and H2O .
16852428	0	La2O3	21,26	CCl4	62,66	La2O3	CCl4	MESH:C103829	6351	Chemical	Gene	activity|nmod|START_ENTITY activity|nmod|END_ENTITY	Relative activity of La2O3 , LaOCl , and LaCl3 in reaction with CCl4 studied with infrared spectroscopy and density functional theory calculations .
23839987	0	Laccaic_acid_A	0,14	DNA_methyltransferase_1	57,80	Laccaic acid A	DNA methyltransferase 1	null	1786	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Laccaic_acid_A is a direct , DNA-competitive inhibitor of DNA_methyltransferase_1 .
25610063	0	Lacidipine	11,21	BNP	55,58	Lacidipine	BNP	MESH:C060285	25105(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|Levels Levels|compound|END_ENTITY	Effects of Lacidipine , Ramipril and Valsartan on Serum BNP Levels in Acute and Chronic Periods Following Isoproterenol-Induced Myocardial_Infarction in Rats .
9488215	0	Lacidipine	0,10	NF-kappaB	63,72	Lacidipine	NF-kappaB	MESH:C060285	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	Lacidipine inhibits the activation of the transcription factor NF-kappaB and the expression of adhesion molecules induced by pro-oxidant signals on endothelial cells .
25931268	0	Lacosamide	0,10	HDAC	19,23	Lacosamide	HDAC	MESH:C403507	9734	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|levels levels|compound|END_ENTITY	Lacosamide reduces HDAC levels in the brain and improves memory : Potential for treatment of Alzheimer 's _ disease .
26729049	0	Lacosamide	0,10	calcitonin_gene-related_peptide	20,51	Lacosamide	calcitonin gene-related peptide	MESH:C403507	24241(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Lacosamide inhibits calcitonin_gene-related_peptide production and release at trigeminal level in the rat .
8885994	0	Lactacystin	0,11	LDL_receptor	22,34	Lactacystin	LDL receptor	MESH:C067713	3949	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|level level|compound|END_ENTITY	Lactacystin increases LDL_receptor level on HepG2 cells .
11399945	0	Lactacystin	0,11	cathepsin_A	21,32	Lactacystin	cathepsin A	MESH:C067713	19025(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	Lactacystin inhibits cathepsin_A activity in melanoma cell lines .
24194865	0	Lactadherin	0,11	secretory_phospholipase_A2	21,47	Lactadherin	secretory phospholipase A2	null	5320	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Lactadherin inhibits secretory_phospholipase_A2 activity on pre-apoptotic leukemia cells .
26769382	0	Lactate	0,7	FGF21	16,21	Lactate	FGF21	MESH:D019344	56636(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nummod|END_ENTITY	Lactate induces FGF21 expression in adipocytes through a p38-MAPK pathway .
23082126	0	Lactate	0,7	HIF-1	18,23	Lactate	HIF-1	MESH:D019344	3091	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Lactate activates HIF-1 in oxidative but not in Warburg-phenotype human tumor cells .
18521687	0	Lactate	0,7	HIF-1alpha	111,121	Lactate	HIF-1alpha	MESH:D019344	3091	Chemical	Gene	START_ENTITY|dobj|association association|appos|END_ENTITY	Lactate dehydrogenase-5 -LRB- LDH-5 -RRB- expression in human gastric_cancer : association with hypoxia-inducible factor -LRB- HIF-1alpha -RRB- pathway , angiogenic factors production and poor prognosis .
10981713	0	Lactate	0,7	MCT1	86,90	Lactate	MCT1	MESH:D019344	25027(Tax:10116)	Chemical	Gene	transport|amod|START_ENTITY transport|dep|identification identification|nmod|transporter transporter|appos|END_ENTITY	Lactate transport in rat adipocytes : identification of monocarboxylate transporter 1 -LRB- MCT1 -RRB- and its modulation during streptozotocin-induced diabetes .
17395833	0	Lactate	0,7	MCT1	74,78	Lactate	MCT1	MESH:D019344	6566	Chemical	Gene	network|amod|START_ENTITY network|dep|activation activation|nmod|biogenesis biogenesis|compound|END_ENTITY	Lactate sensitive transcription factor network in L6 cells : activation of MCT1 and mitochondrial biogenesis .
21300765	0	Lactate	0,7	MCT1	72,76	Lactate	MCT1	MESH:D019344	6566	Chemical	Gene	influx|amod|START_ENTITY monocarboxylate|nsubj|influx monocarboxylate|ccomp|supports supports|nsubj|END_ENTITY	Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-kB/IL -8 pathway that drives tumor angiogenesis .
22323521	0	Lactate	0,7	histone_deacetylase	54,73	Lactate	histone deacetylase	MESH:D019344	9734	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Lactate , a product of glycolytic metabolism , inhibits histone_deacetylase activity and promotes changes in gene expression .
10333080	0	Lactate	0,7	insulin	19,26	Lactate	insulin	MESH:D019344	3630	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|compound|END_ENTITY	Lactate stimulates insulin secretion without blocking the K + channels in HIT-T15_insulinoma cells .
16896001	0	Lactate	0,7	vascular_endothelial_growth_factor	113,147	Lactate	vascular endothelial growth factor	MESH:D019344	7422	Chemical	Gene	expression|amod|START_ENTITY expression|dep|association association|nmod|pathway pathway|compound|END_ENTITY	Lactate dehydrogenase 5 expression in operable colorectal_cancer : strong association with survival and activated vascular_endothelial_growth_factor pathway -- a report of the Tumour Angiogenesis Research Group .
17116616	0	Lactate	0,7	vascular_endothelial_growth_factor	27,61	Lactate	vascular endothelial growth factor	MESH:D019344	7422	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	Lactate dehydrogenase , not vascular_endothelial_growth_factor or basic_fibroblast_growth_factor , positively correlates to bone_marrow_vascularity in acute_myeloid_leukemia .
20026743	0	Lactic_acid	0,11	TNF	38,41	Lactic acid	TNF	MESH:D019344	7124	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|secretion secretion|compound|END_ENTITY	Lactic_acid and acidification inhibit TNF secretion and glycolysis of human monocytes .
18406487	0	Lactic_acid	0,11	aquaporin_4	22,33	Lactic acid	aquaporin 4	MESH:D019344	25293(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Lactic_acid increases aquaporin_4 expression on the cell membrane of cultured rat astrocytes .
21118312	0	Lactic_acid	0,11	interleukin-23	23,37	Lactic acid	interleukin-23	MESH:D019344	27178	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|amod|END_ENTITY	Lactic_acid stimulates interleukin-23 production by peripheral blood mononuclear cells exposed to bacterial lipopolysaccharide .
26116537	0	Lactobionic_acid	0,16	galectin-1	95,105	Lactobionic acid	galectin-1	MESH:C005608	56646(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|nmod|inhibition inhibition|nmod|END_ENTITY	Lactobionic_acid reduces body weight_gain in diet-induced obese rats by targeted inhibition of galectin-1 .
23296204	0	Lactoferrin	0,11	BMP7	22,26	Lactoferrin	BMP7	null	655	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Lactoferrin activates BMP7 gene expression through the mitogen-activated protein kinase ERK pathway in articular cartilage .
11895948	0	Lactoferrin	0,11	interleukin-8	99,112	Lactoferrin	interleukin-8	null	3576	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Lactoferrin inhibits the lipopolysaccharide-induced expression and proteoglycan-binding ability of interleukin-8 in human endothelial cells .
6365377	0	Lactoferrin	0,11	leucocyte_migration_inhibitory_factor	41,78	Lactoferrin	leucocyte migration inhibitory factor	null	3976	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|nmod|END_ENTITY	Lactoferrin stimulates the production of leucocyte_migration_inhibitory_factor by human peripheral mononuclear leucocytes .
2834974	0	Lactoferrin	0,11	myeloperoxidase	13,28	Lactoferrin	myeloperoxidase	null	4353	Chemical	Gene	START_ENTITY|appos|protein protein|amod|END_ENTITY	Lactoferrin , myeloperoxidase , lysozyme and eosinophil cationic protein in exudate in delayed_type_hypersensitivity .
24881213	0	Lactoferrin	1,12	toll_like_receptor_4	45,65	Lactoferrin	toll like receptor 4	null	7099	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|nmod|END_ENTITY	-LSB- Lactoferrin downregulates the expression of toll_like_receptor_4 stimulated by lipopolysaccharide in human periodontal ligament cells -RSB- .
22382519	0	Lactogens	0,9	Janus_kinase-2	99,113	Lactogens	Janus kinase-2	null	3717	Chemical	Gene	protect|nsubj|START_ENTITY protect|nmod|END_ENTITY	Lactogens protect rodent and human beta cells against glucolipotoxicity-induced cell death through Janus_kinase-2 -LRB- JAK2 -RRB- / signal transducer and activator of transcription-5 -LRB- STAT5 -RRB- signalling .
18588125	0	Lactose	0,7	beta-galactosidase	34,52	Lactose	beta-galactosidase	MESH:D007785	2720	Chemical	Gene	hydrolysis|nsubj|START_ENTITY hydrolysis|nmod|END_ENTITY	Lactose hydrolysis by immobilized beta-galactosidase in capillary bed reactor .
9308365	0	Lactose	0,7	repressor	8,17	Lactose	repressor	MESH:D007785	3722458(Tax:562)	Chemical	Gene	protein|amod|START_ENTITY protein|compound|END_ENTITY	Lactose repressor protein : functional properties and structure .
19465542	0	Lactosylceramide	0,16	ERK1/2	81,87	Lactosylceramide	ERK1/2	MESH:C009744	5595;5594	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|activation activation|nmod|END_ENTITY	Lactosylceramide promotes cell migration and proliferation through activation of ERK1/2 in human aortic smooth muscle cells .
24520266	0	Lactuside_B	0,11	aquaporin-4	22,33	Lactuside B	aquaporin-4	MESH:C581344	25293(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|amod|END_ENTITY	Lactuside_B decreases aquaporin-4 and caspase-3 mRNA expression in the hippocampus and striatum following cerebral ischaemia-reperfusion injury in rats .
12577045	0	Lafutidine	0,10	calcitonin_gene-related_peptide	70,101	Lafutidine	calcitonin gene-related peptide	MESH:C076948	24241(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Lafutidine , a novel histamine_H2-receptor antagonist , increases serum calcitonin_gene-related_peptide in rats after water immersion-restraint stress .
18344609	0	Lafutidine	0,10	calcitonin_gene-related_peptide	23,54	Lafutidine	calcitonin gene-related peptide	MESH:C076948	24241(Tax:10116)	Chemical	Gene	facilitates|amod|START_ENTITY END_ENTITY|nsubj|facilitates	Lafutidine facilitates calcitonin_gene-related_peptide -LRB- CGRP -RRB- nerve-mediated vasodilation via vanilloid-1 receptors in rat mesenteric resistance arteries .
8393850	0	Lagunamycin	0,11	5-lipoxygenase	21,35	Lagunamycin	5-lipoxygenase	MESH:C082420	25290(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Lagunamycin , a novel 5-lipoxygenase inhibitor .
6841971	0	Laminin	0,7	C1300	26,31	Laminin	C1300	null	1034995(Tax:199310)	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Laminin in cultured mouse C1300 neuroblastoma cells : immunocytochemical localization by pre - and postembedding electron microscope procedures .
16690036	0	Laminin	0,7	CaMK-II	18,25	Laminin	CaMK-II	null	12323(Tax:10090)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Laminin activates CaMK-II to stabilize nascent embryonic axons .
18502047	0	Laminin	0,7	NF-kappaB	18,27	Laminin	NF-kappaB	null	18033(Tax:10090)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Laminin activates NF-kappaB in Schwann cells to enhance neurite outgrowth .
2973567	0	Laminin	0,7	VLA-6	46,51	Laminin	VLA-6	null	3655	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|nsubj|receptor	Laminin receptor on platelets is the integrin VLA-6 .
10878099	0	Laminin	0,7	beta_1_integrin	17,32	Laminin	beta 1 integrin	null	3688	Chemical	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	Laminin acts via beta_1_integrin signalling to alter cholinergic regulation of L-type Ca -LRB- 2 + -RRB- current in cat atrial myocytes .
12717831	0	Laminin	0,7	cytokeratin_19	34,48	Laminin	cytokeratin 19	null	3880	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Laminin induces the expression of cytokeratin_19 in hepatocellular_carcinoma cells growing in culture .
2867097	0	Laminin	0,7	tyrosine_hydroxylase	46,66	Laminin	tyrosine hydroxylase	null	280707(Tax:9913)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|nmod|END_ENTITY	Laminin increases both levels and activity of tyrosine_hydroxylase in calf adrenal chromaffin cells .
18784072	0	Laminin-332	0,11	hepsin	31,37	Laminin-332	hepsin	MESH:C076524	3249	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Laminin-332 is a substrate for hepsin , a protease associated with prostate_cancer progression .
26213157	0	Lamotrigine	60,71	ABCG2	17,22	Lamotrigine	ABCG2	MESH:C047781	9429	Chemical	Gene	concentrations|amod|START_ENTITY associated|nmod|concentrations associated|nsubjpass|Polymorphisms Polymorphisms|nmod|END_ENTITY	Polymorphisms of ABCG2 , ABCB1 and HNF4a are associated with Lamotrigine trough concentrations in epilepsy patients .
22227272	0	Lamotrigine	0,11	OCT1	31,35	Lamotrigine	OCT1	MESH:C047781	6580	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Lamotrigine is a substrate for OCT1 in brain endothelial cells .
18190784	0	Lamotrigine	0,11	TRESK	21,26	Lamotrigine	TRESK	MESH:C047781	332396(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Lamotrigine inhibits TRESK regulated by G-protein coupled receptor agonists .
9416765	0	Lamotrigine	0,11	tyrosine_hydroxylase	45,65	Lamotrigine	tyrosine hydroxylase	MESH:C047781	21823(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	Lamotrigine inhibits the in situ activity of tyrosine_hydroxylase in striatum of audiogenic seizure-prone and audiogenic seizure-resistant Balb/c mice .
21757445	0	Lanatoside_C	0,12	tumor_necrosis_factor-related_apoptosis-inducing_ligand	46,101	Lanatoside C	tumor necrosis factor-related apoptosis-inducing ligand	MESH:C018548	8743	Chemical	Gene	sensitizes|nsubj|START_ENTITY sensitizes|nmod|END_ENTITY	Lanatoside_C sensitizes glioblastoma cells to tumor_necrosis_factor-related_apoptosis-inducing_ligand and induces an alternative cell death pathway .
17717219	0	Landiolol	0,9	beta1-adrenoceptor	33,51	Landiolol	beta1-adrenoceptor	MESH:C077049	397355(Tax:9823)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Landiolol , an ultra short-acting beta1-adrenoceptor antagonist , does not alter the minimum alveolar anesthetic concentration of isoflurane in a swine model .
18791493	0	Landiolol	0,9	beta1-adrenoceptor	32,50	Landiolol	beta1-adrenoceptor	MESH:C077049	24925(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Landiolol , an ultrashort-acting beta1-adrenoceptor antagonist , has protective effects in an LPS-induced systemic inflammation model .
16567345	0	Landiolol	0,9	beta_1-adrenoceptor	33,52	Landiolol	beta 1-adrenoceptor	MESH:C077049	397355(Tax:9823)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Landiolol , an ultra-short-acting beta_1-adrenoceptor antagonist , does not alter the electroencephalographic effect of isoflurane in swine model .
21107016	0	Laninamivir	0,11	neuraminidase	50,63	Laninamivir	neuraminidase	MESH:C546918	4758	Chemical	Gene	START_ENTITY|dep|inhibitors inhibitors|compound|END_ENTITY	Laninamivir and its prodrug , CS-8958 : long-acting neuraminidase inhibitors for the treatment of influenza .
21973296	0	Laninamivir_octanoate	0,21	neuraminidase	41,54	Laninamivir octanoate	neuraminidase	MESH:C546918	4758	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Laninamivir_octanoate : a new long-acting neuraminidase inhibitor for the treatment of influenza .
25577284	0	Lanostanoids	0,12	acetylcholinesterase	18,38	Lanostanoids	acetylcholinesterase	null	43	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Lanostanoids with acetylcholinesterase inhibitory activity from the mushroom Haddowia longipes .
25844821	0	Lansoprazole	0,12	CYP2C19	78,85	Lansoprazole	CYP2C19	MESH:C058687	1557	Chemical	Gene	Associated|nsubj|START_ENTITY Associated|nmod|Control Control|nmod|Children Children|nmod|Phenotype Phenotype|compound|END_ENTITY	Lansoprazole Is Associated with Worsening Asthma Control in Children with the CYP2C19 Poor Metabolizer Phenotype .
12438555	0	Lansoprazole	0,12	cyclooxygenase-2	92,108	Lansoprazole	cyclooxygenase-2	MESH:C058687	29527(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|up-regulation up-regulation|nmod|END_ENTITY	Lansoprazole induces mucosal protection through gastrin receptor-dependent up-regulation of cyclooxygenase-2 in rats .
12438555	0	Lansoprazole	0,12	gastrin	48,55	Lansoprazole	gastrin	MESH:C058687	25320(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|up-regulation up-regulation|amod|END_ENTITY	Lansoprazole induces mucosal protection through gastrin receptor-dependent up-regulation of cyclooxygenase-2 in rats .
1355746	0	Lansoprazole	0,12	gastrin	59,66	Lansoprazole	gastrin	MESH:C058687	25320(Tax:10116)	Chemical	Gene	have|nsubj|START_ENTITY have|nmod|levels levels|compound|END_ENTITY	Lansoprazole and omeprazole have similar effects on plasma gastrin levels , enterochromaffin-like cells , gastrin cells and somatostatin cells in the rat stomach .
20233740	0	Lanthanum	0,9	calcium-sensing_receptor	20,44	Lanthanum	calcium-sensing receptor	MESH:D007811	846	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Lanthanum activates calcium-sensing_receptor and enhances sensitivity to calcium .
16502327	0	Lanthanum	0,9	extracellular_signal-regulated_kinase	18,55	Lanthanum	extracellular signal-regulated kinase	MESH:D007811	5594	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|amod|END_ENTITY	Lanthanum induces extracellular_signal-regulated_kinase phosphorylation through different mechanisms in HeLa cells and NIH 3T3 cells .
25556148	0	Lanthanum_Carbonate	95,114	Parathyroid_Hormone	162,181	Lanthanum Carbonate	Parathyroid Hormone	MESH:C119467	5741	Chemical	Gene	START_ENTITY|nmod|Patients Patients|nmod|END_ENTITY	Restoration of Parathyroid Function After Change of Phosphate Binder From Calcium_Carbonate to Lanthanum_Carbonate in Hemodialysis Patients With Suppressed Serum Parathyroid_Hormone .
21436379	0	Lanthanum_carbonate	0,19	FGF23	28,33	Lanthanum carbonate	FGF23	MESH:C119467	8074	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	Lanthanum_carbonate reduces FGF23 in chronic_kidney_disease Stage 3 patients .
17090605	0	Lanthanum_carbonate	0,19	PTH	30,33	Lanthanum carbonate	PTH	MESH:C119467	24694(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|compound|END_ENTITY	Lanthanum_carbonate decreases PTH gene expression with no hepatotoxicity in uraemic rats .
3089219	0	Lapachol	0,8	DT-diaphorase	23,36	Lapachol	DT-diaphorase	MESH:C008252	1728	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Lapachol inhibition of DT-diaphorase -LRB- NAD -LRB- P -RRB- H : quinone dehydrogenase -RRB- .
18587443	0	Lapaquistat_acetate	0,19	squalene_synthase	23,40	Lapaquistat acetate	squalene synthase	null	100345480(Tax:9986)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Lapaquistat_acetate , a squalene_synthase inhibitor , changes macrophage/lipid-rich coronary plaques of hypercholesterolaemic rabbits into fibrous_lesions .
17250463	0	Lapatinib	0,9	EGFR	31,35	Lapatinib	EGFR	MESH:C490728	1956	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|activity activity|compound|END_ENTITY	Lapatinib : a dual inhibitor of EGFR and HER2 tyrosine kinase activity .
19529774	0	Lapatinib	0,9	EGFR	137,141	Lapatinib	EGFR	MESH:C490728	1956	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|xcomp|thymidylate_synthase thymidylate_synthase|advcl|inhibiting inhibiting|dobj|translocation translocation|nmod|END_ENTITY	Lapatinib , a dual EGFR and HER2 tyrosine kinase inhibitor , downregulates thymidylate_synthase by inhibiting the nuclear translocation of EGFR and HER2 .
21106881	5	Lapatinib	839,848	EGFR	931,935	Lapatinib	EGFR	MESH:C490728	24329(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|epidermal_growth_factor_receptor epidermal_growth_factor_receptor|appos|END_ENTITY	Lapatinib , a dual tyrosine kinase inhibitor -LRB- TKI -RRB- of both epidermal_growth_factor_receptor -LRB- EGFR -RRB- / ErbB1 and HER2 , blocked receptor signaling , and suppressed PRL expression more than gefitinib , a TKI of EGFR/ErbB1 .
21293538	0	Lapatinib	0,9	EGFR	66,70	Lapatinib	EGFR	MESH:C490728	1956	Chemical	Gene	START_ENTITY|dep|significance significance|appos|END_ENTITY	Lapatinib in breast_cancer - the predictive significance of HER1 -LRB- EGFR -RRB- , HER2 , PTEN and PIK3CA genes and lapatinib plasma level assessment .
22293713	0	Lapatinib	0,9	EGFR	31,35	Lapatinib	EGFR	MESH:C490728	1956	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Lapatinib , a dual inhibitor of EGFR and HER2 , has synergistic effects with 5-fluorouracil on esophageal_carcinoma .
22885469	0	Lapatinib	0,9	EGFR	44,48	Lapatinib	EGFR	MESH:C490728	1956	Chemical	Gene	value|compound|START_ENTITY value|nmod|mutations mutations|amod|END_ENTITY	Lapatinib and potential prognostic value of EGFR mutations in a Gynecologic Oncology Group phase II trial of persistent or recurrent endometrial_cancer .
26114862	0	Lapatinib	56,65	EGFR	22,26	Lapatinib	EGFR	MESH:C490728	1956	Chemical	Gene	dual|nmod|START_ENTITY dual|nmod|END_ENTITY	The dual targeting of EGFR and ErbB2 with the inhibitor Lapatinib corrects high glucose-induced apoptosis and vascular_dysfunction by opposing multiple diabetes-induced signaling changes .
25348000	0	Lapatinib	221,230	Epidermal_Growth_Factor_Receptor	48,80	Lapatinib	Epidermal Growth Factor Receptor	MESH:C490728	1956	Chemical	Gene	Randomized|nmod|START_ENTITY Therapy|parataxis|Randomized Therapy|nmod|Inhibition Inhibition|nmod|END_ENTITY	Endocrine Therapy With or Without Inhibition of Epidermal_Growth_Factor_Receptor and Human_Epidermal_Growth_Factor_Receptor_2 : A Randomized , Double-Blind , Placebo-Controlled Phase III Trial of Fulvestrant With or Without Lapatinib for Postmenopausal Women With Hormone Receptor-Positive Advanced_Breast_Cancer-CALGB_40302 -LRB- Alliance -RRB- .
24669898	0	Lapatinib	1,10	HER-2	33,38	Lapatinib	HER-2	MESH:C490728	2064	Chemical	Gene	START_ENTITY|nmod|breast_cancer breast_cancer|compound|END_ENTITY	-LSB- Lapatinib plus transtuzumab for HER-2 positiva metastatic breast_cancer : experience of use -RSB- .
19060928	0	Lapatinib	0,9	HER2	13,17	Lapatinib	HER2	MESH:C490728	2064	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Lapatinib , a HER2 tyrosine kinase inhibitor , induces stabilization and accumulation of HER2 and potentiates trastuzumab-dependent cell cytotoxicity .
19060928	0	Lapatinib	0,9	HER2	87,91	Lapatinib	HER2	MESH:C490728	2064	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|stabilization stabilization|nmod|END_ENTITY	Lapatinib , a HER2 tyrosine kinase inhibitor , induces stabilization and accumulation of HER2 and potentiates trastuzumab-dependent cell cytotoxicity .
19153829	0	Lapatinib	0,9	HER2	58,62	Lapatinib	HER2	MESH:C490728	2064	Chemical	Gene	START_ENTITY|nmod|breast_cancer breast_cancer|amod|capecitabine capecitabine|nmod|END_ENTITY	Lapatinib plus capecitabine versus capecitabine alone for HER2 + -LRB- ErbB2 + -RRB- metastatic breast_cancer : quality-of-life assessment .
19394894	0	Lapatinib	0,9	HER2	153,157	Lapatinib	HER2	MESH:C490728	2064	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|relapsed relapsed|dep|results results|nmod|cohort cohort|compound|END_ENTITY	Lapatinib monotherapy in patients with HER2-overexpressing relapsed or refractory inflammatory_breast_cancer : final results and survival of the expanded HER2 + cohort in EGF103009 , a phase II study .
19593514	0	Lapatinib	0,9	HER2	29,33	Lapatinib	HER2	MESH:C490728	2064	Chemical	Gene	START_ENTITY|parataxis|directed directed|nsubj|directions directions|nmod|END_ENTITY	Lapatinib : new directions in HER2 directed therapy for early stage breast_cancer .
20457354	0	Lapatinib	0,9	HER2	69,73	Lapatinib	HER2	MESH:C490728	13866(Tax:10090)	Chemical	Gene	diminishes|nsubj|START_ENTITY diminishes|nmod|+ +|compound|END_ENTITY	Lapatinib in combination with radiation diminishes tumor regrowth in HER2 + and basal-like/EGFR + breast_tumor xenografts .
20658522	0	Lapatinib	0,9	HER2	82,86	Lapatinib	HER2	MESH:C490728	2064	Chemical	Gene	augments|nsubj|START_ENTITY augments|dobj|cleavage cleavage|nmod|domain domain|compound|END_ENTITY	Lapatinib , a dual HER1/HER2 tyrosine kinase inhibitor , augments basal cleavage of HER2 extracellular domain -LRB- ECD -RRB- to inhibit HER2-driven cancer cell growth .
21570197	0	Lapatinib	26,35	HER2	50,54	Lapatinib	HER2	MESH:C490728	2064	Chemical	Gene	resistance|compound|START_ENTITY resistance|nmod|cells cells|nummod|END_ENTITY	Autophagy facilitates the Lapatinib resistance of HER2 positive breast_cancer cells .
21868551	0	Lapatinib	0,9	HER2	112,116	Lapatinib	HER2	MESH:C490728	2064	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|up-regulation up-regulation|nmod|expression expression|compound|END_ENTITY	Lapatinib enhances herceptin-mediated antibody-dependent_cellular_cytotoxicity by up-regulation of cell surface HER2 expression .
22011930	0	Lapatinib	0,9	HER2	26,30	Lapatinib	HER2	MESH:C490728	13866(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|distribution distribution|nmod|END_ENTITY	Lapatinib distribution in HER2 overexpressing experimental brain metastases of breast_cancer .
22152751	0	Lapatinib	0,9	HER2	206,210	Lapatinib	HER2	MESH:C490728	2064	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|nmod|treatment treatment|nmod|breast_cancer breast_cancer|acl:relcl|over-expresses over-expresses|dobj|factor factor|dep|2 2|appos|END_ENTITY	Lapatinib and trastuzumab in combination with an aromatase inhibitor for the first-line treatment of metastatic hormone receptor-positive breast_cancer which over-expresses human epidermal growth factor 2 -LRB- HER2 -RRB- : a systematic review and economic analysis .
23024989	0	Lapatinib	0,9	HER2	166,170	Lapatinib	HER2	MESH:C490728	2064	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|nmod|treatment treatment|nmod|breast_cancer breast_cancer|acl:relcl|overexpresses overexpresses|dobj|END_ENTITY	Lapatinib or trastuzumab in combination with an aromatase inhibitor for first-line treatment of metastatic hormone-receptor-positive breast_cancer that overexpresses HER2 .
23948998	0	Lapatinib	0,9	HER2	59,63	Lapatinib	HER2	MESH:C490728	2064	Chemical	Gene	START_ENTITY|dobj|sensitivities sensitivities|nmod|lines lines|compound|END_ENTITY	Lapatinib sensitivities of two novel trastuzumab-resistant HER2 gene-amplified gastric_cancer cell lines .
24191208	0	Lapatinib	89,98	HER2	50,54	Lapatinib	HER2	MESH:C490728	2064	Chemical	Gene	Breast_Cancer|nmod|START_ENTITY Breast_Cancer|compound|END_ENTITY	Nearly Complete Response of Brain Metastases from HER2 Overexpressing Breast_Cancer with Lapatinib and Capecitabine after Whole Brain Irradiation .
25841741	0	Lapatinib	0,9	HER2	59,63	Lapatinib	HER2	MESH:C490728	2064	Chemical	Gene	START_ENTITY|nmod|breast_cancer breast_cancer|compound|END_ENTITY	Lapatinib as a therapeutic option in brain metastases from HER2 + breast_cancer .
25987098	0	Lapatinib	36,45	HER2	68,72	Lapatinib	HER2	MESH:C490728	2064	Chemical	Gene	START_ENTITY|nmod|Cancer Cancer|compound|END_ENTITY	Trastuzumab-based Retreatment after Lapatinib in Heavily Pretreated HER2 Positive Metastatic Breast Cancer : an Anatolian Society of Medical Oncology Study .
25987098	0	Lapatinib	36,45	HER2	68,72	Lapatinib	HER2	MESH:C490728	2064	Chemical	Gene	START_ENTITY|nmod|Cancer Cancer|compound|END_ENTITY	Trastuzumab-based Retreatment after Lapatinib in Heavily Pretreated HER2 Positive Metastatic Breast Cancer : an Anatolian Society of Medical Oncology Study .
26134366	0	Lapatinib	54,63	HER2	17,21	Lapatinib	HER2	MESH:C490728	2064	Chemical	Gene	Cells|nmod|START_ENTITY Cells|compound|END_ENTITY	Sensitization of HER2 Positive Breast_Cancer Cells to Lapatinib Using Plants-Derived Isothiocyanates .
26134366	0	Lapatinib	54,63	HER2	17,21	Lapatinib	HER2	MESH:C490728	2064	Chemical	Gene	Cells|nmod|START_ENTITY Cells|compound|END_ENTITY	Sensitization of HER2 Positive Breast_Cancer Cells to Lapatinib Using Plants-Derived Isothiocyanates .
26484410	0	Lapatinib	21,30	HER2	51,55	Lapatinib	HER2	MESH:C490728	2064	Chemical	Gene	START_ENTITY|nmod|treatment treatment|nmod|END_ENTITY	Molecular effects of Lapatinib in the treatment of HER2 overexpressing oesophago-gastric adenocarcinoma .
26503698	0	Lapatinib	0,9	HER2	101,105	Lapatinib	HER2	MESH:C490728	2064	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|antibody-dependent_cellular_cytotoxicity antibody-dependent_cellular_cytotoxicity|nmod|upregulation upregulation|nmod|END_ENTITY	Lapatinib enhances trastuzumab-mediated antibody-dependent_cellular_cytotoxicity via upregulation of HER2 in malignant mesothelioma cells .
23907131	0	Lapatinib	0,9	Kip1	22,26	Lapatinib	Kip1	MESH:C490728	1027	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Lapatinib induces p27 -LRB- Kip1 -RRB- - dependent G arrest through both transcriptional and post-translational mechanisms .
15374980	0	Lapatinib	75,84	epidermal_growth_factor_receptor	23,55	Lapatinib	epidermal growth factor receptor	MESH:C490728	1956	Chemical	Gene	GW572016|appos|START_ENTITY bound|nmod|GW572016 END_ENTITY|acl|bound	A unique structure for epidermal_growth_factor_receptor bound to GW572016 -LRB- Lapatinib -RRB- : relationships among protein conformation , inhibitor off-rate , and receptor activity in tumor cells .
18803986	0	Lapatinib	0,9	epidermal_growth_factor_receptor	37,69	Lapatinib	epidermal growth factor receptor	MESH:C490728	1956	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|kinases kinases|compound|END_ENTITY	Lapatinib : a dual inhibitor of human epidermal_growth_factor_receptor tyrosine kinases .
20110044	0	Lapatinib	0,9	epidermal_growth_factor_receptor	41,73	Lapatinib	epidermal growth factor receptor	MESH:C490728	1956	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|kinases kinases|compound|END_ENTITY	Lapatinib : a small-molecule inhibitor of epidermal_growth_factor_receptor and human epidermal_growth_factor_receptor-2 tyrosine kinases used in the treatment of breast_cancer .
22458639	0	Lapatinib	0,9	epidermal_growth_factor_receptor	31,63	Lapatinib	epidermal growth factor receptor	MESH:C490728	1956	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|epidermal_growth_factor_receptor_2 epidermal_growth_factor_receptor_2|compound|END_ENTITY	Lapatinib , a dual inhibitor of epidermal_growth_factor_receptor and human epidermal_growth_factor_receptor_2 , potentiates the antitumor effects of cisplatin on esophageal_carcinoma .
25513704	1	Lapatinib	12,21	epidermal_growth_factor_receptor	43,75	Lapatinib	epidermal growth factor receptor	MESH:C490728	1956	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Lapatinib , a dual inhibitor of epidermal_growth_factor_receptor and human epidermal_growth_factor_receptor 2 , potentiates the antitumor effects of cisplatin on esophageal_carcinoma .
26500253	0	Larixyl_Acetate	33,48	TRPC6	61,66	Larixyl Acetate	TRPC6	null	89823(Tax:10116)	Chemical	Gene	Identification|nmod|START_ENTITY Identification|nmod|Inhibitor Inhibitor|compound|END_ENTITY	Identification and Validation of Larixyl_Acetate as a Potent TRPC6 Inhibitor .
12164392	0	Lauryl_gallate	0,14	c-Src	64,69	Lauryl gallate	c-Src	MESH:C008259	6714	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	Lauryl_gallate inhibits the activity of protein_tyrosine_kinase c-Src purified from human platelets .
7931245	0	Lazabemide	0,10	MAO-B	59,64	Lazabemide	MAO-B	MESH:C059303	25750(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Lazabemide -LRB- Ro_19-6327 -RRB- , a reversible and highly sensitive MAO-B inhibitor : preclinical and clinical findings .
12359039	0	Lazabemide	0,10	monoamine_oxidase_B	36,55	Lazabemide	monoamine oxidase B	MESH:C059303	4129	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Lazabemide , a selective , reversible monoamine_oxidase_B inhibitor , as an aid to smoking cessation .
25957738	0	Lazaroid_U-74389G	0,17	glucocorticoid_receptor	117,140	Lazaroid U-74389G	glucocorticoid receptor	null	2908	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Lazaroid_U-74389G inhibits the osteoblastic differentiation of IL-1b-indcued aortic valve interstitial cells through glucocorticoid_receptor and inhibition of NF-kB pathway .
12662048	0	Le	97,99	PSGL-1	116,122	Le	PSGL-1	null	6404	Chemical	Gene	structure|compound|START_ENTITY structure|nmod|END_ENTITY	Complex oligosaccharide investigations : synthesis of an octasaccharide incorporating the dimeric Le -LRB- x -RRB- structure of PSGL-1 .
23024474	0	Lecithin	10,18	Bcl-2	101,106	Lecithin	Bcl-2	MESH:D054709	24224(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|amod|END_ENTITY	Effect of Lecithin on d-Galactosamine Induced Hepatotoxicity Through Mitochondrial Pathway Involving Bcl-2 and Bax .
9683394	0	Lecithin	0,8	fibrinogen	52,62	Lecithin	fibrinogen	MESH:D054709	2244	Chemical	Gene	has|nsubj|START_ENTITY has|dobj|effect effect|nmod|END_ENTITY	Lecithin has no effect on serum lipoprotein , plasma fibrinogen and macro molecular protein complex levels in hyperlipidaemic men in a double-blind controlled study .
19324522	0	Leflunomide	37,48	cytokine	52,60	Leflunomide	cytokine	MESH:C045463	943	Chemical	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Sex hormones modulate the effects of Leflunomide on cytokine production by cultures of differentiated monocyte/macrophages and synovial macrophages from rheumatoid_arthritis patients .
11166726	0	Leflunomide	0,11	inducible_nitric_oxide_synthase	35,66	Leflunomide	inducible nitric oxide synthase	MESH:C045463	24599(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	Leflunomide inhibits activation of inducible_nitric_oxide_synthase in rat astrocytes .
26131937	0	Lenalidomide	0,12	CK1a	55,59	Lenalidomide	CK1a	MESH:C467567	93687(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|ubiquitination ubiquitination|nmod|END_ENTITY	Lenalidomide induces ubiquitination and degradation of CK1a in del -LRB- 5q -RRB- MDS .
25610725	0	Lenalidomide	0,12	IKZF1	36,41	Lenalidomide	IKZF1	MESH:C467567	10320	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|degradation degradation|nmod|END_ENTITY	Lenalidomide induces degradation of IKZF1 and IKZF3 .
21935729	0	Leptazol	107,115	Glutamate_decarboxylase	0,23	Leptazol	Glutamate decarboxylase	null	24957(Tax:10116)	Chemical	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	Glutamate_decarboxylase and GABA_aminotransferase levels in different regions of rat brain on the onset of Leptazol induced convulsions .
12468543	0	Leptomycin_B	0,12	COX-2	73,78	Leptomycin B	COX-2	MESH:C038753	4513	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Leptomycin_B , an inhibitor of the nuclear export receptor CRM1 , inhibits COX-2 expression .
12468543	0	Leptomycin_B	0,12	CRM1	58,62	Leptomycin B	CRM1	MESH:C038753	7514	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Leptomycin_B , an inhibitor of the nuclear export receptor CRM1 , inhibits COX-2 expression .
23297231	0	Leptomycin_B	73,85	CRM1	89,93	Leptomycin B	CRM1	MESH:C038753	7514	Chemical	Gene	conjugation|nmod|START_ENTITY export|nmod|conjugation export|nmod|END_ENTITY	Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin_B by CRM1 .
9683540	0	Leptomycin_B	0,12	CRM1	79,83	Leptomycin B	CRM1	MESH:C038753	7514	Chemical	Gene	START_ENTITY|nmod|direct direct|nmod|END_ENTITY	Leptomycin_B inhibition of signal-mediated nuclear export by direct binding to CRM1 .
17088990	0	Leptomycin_B	0,12	inducible_nitric_oxide_synthase	71,102	Leptomycin B	inducible nitric oxide synthase	MESH:C038753	18126(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Leptomycin_B , a metabolite of Streptomyces , inhibits the expression of inducible_nitric_oxide_synthase in BV2 microglial cells .
21082990	0	Lestaurtinib	0,12	FLT3	31,35	Lestaurtinib	FLT3	MESH:C119379	2322	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Lestaurtinib : a multi-targeted FLT3 inhibitor .
17984313	0	Lestaurtinib	0,12	JAK2	27,31	Lestaurtinib	JAK2	MESH:C119379	3717	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|compound|END_ENTITY	Lestaurtinib -LRB- CEP701 -RRB- is a JAK2 inhibitor that suppresses JAK2/STAT5 signaling and the proliferation of primary erythroid cells from patients with myeloproliferative_disorders .
24550587	0	Lettuce_glycoside_B	0,19	nerve_growth_factor	83,102	Lettuce glycoside B	nerve growth factor	null	310738(Tax:10116)	Chemical	Gene	ameliorates|nsubj|START_ENTITY ameliorates|nmod|END_ENTITY	Lettuce_glycoside_B ameliorates cerebral_ischemia reperfusion injury by increasing nerve_growth_factor and neurotrophin-3 expression of cerebral cortex in rats .
17331595	0	Leu-Ile	108,115	glial_cell_line-derived_neurotrophic_factor	15,58	Leu-Ile	glial cell line-derived neurotrophic factor	CHEBI:74540	14573(Tax:10090)	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of glial_cell_line-derived_neurotrophic_factor in inhibitory effects of a hydrophobic dipeptide Leu-Ile on morphine-induced sensitization and rewarding effects .
6993683	0	Leu-Val-Phe-OCH3	41,57	renin	75,80	Leu-Val-Phe-OCH3	renin	null	5972	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	N - -LRB- alpha-Hydroxyalkanoyl -RRB- derivatives of Leu-Val-Phe-OCH3 as inhibitors of renin .
26019275	0	Leucine	33,40	C/EBP	58,63	Leucine	C/EBP	CHEBI:25017	1050	Chemical	Gene	Domain|compound|START_ENTITY Domain|nmod|END_ENTITY	A Novel In-Frame Deletion in the Leucine Zipper Domain of C/EBP Leads to Neutrophil-Specific Granule_Deficiency .
26019275	0	Leucine	33,40	C/EBP	58,63	Leucine	C/EBP	CHEBI:25017	1050	Chemical	Gene	Domain|compound|START_ENTITY Domain|nmod|END_ENTITY	A Novel In-Frame Deletion in the Leucine Zipper Domain of C/EBP Leads to Neutrophil-Specific Granule_Deficiency .
2529117	0	Leucine	0,7	CRE-BP1	40,47	Leucine	CRE-BP1	CHEBI:25017	1386	Chemical	Gene	structure|amod|START_ENTITY structure|nmod|END_ENTITY	Leucine zipper structure of the protein CRE-BP1 binding to the cyclic_AMP response element in brain .
18248013	0	Leucine	114,121	GCN4	109,113	Leucine	GCN4	CHEBI:25017	856709(Tax:4932)	Chemical	Gene	zipper|compound|START_ENTITY zipper|compound|END_ENTITY	Lattice model simulation of interchain protein interactions and the folding dynamics and dimerization of the GCN4 Leucine zipper .
17466941	0	Leucine	0,7	HGF	19,22	Leucine	HGF	CHEBI:25017	3082	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|compound|END_ENTITY	Leucine stimulates HGF production by hepatic stellate cells through mTOR pathway .
2857669	0	Leucine	20,27	Insulin	0,7	Leucine	Insulin	CHEBI:25017	483665(Tax:9615)	Chemical	Gene	turnover|compound|START_ENTITY effect|nmod|turnover effect|nmod:poss|END_ENTITY	Insulin 's effect on Leucine turnover changes during early fasting in the conscious dog .
533513	0	Leucine	0,7	LAP	24,27	Leucine	LAP	CHEBI:25017	289668(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|activity activity|appos|END_ENTITY	Leucine aminopeptidase -LRB- LAP -RRB- activity and sexual dimorphism in rat exorbital lacrimal gland .
26811944	0	Leucine	55,62	LeuT	75,79	Leucine	LeuT	CHEBI:25017	3343	Chemical	Gene	Proteomicelles|compound|START_ENTITY Proteomicelles|compound|END_ENTITY	Role of Annular Lipids in the Functional Properties of Leucine Transporter LeuT Proteomicelles .
25130464	0	Leucine	0,7	PP4C	43,47	Leucine	PP4C	CHEBI:25017	5531	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	Leucine methylation of protein phosphatase PP4C at C-terminal is critical for its cellular functions .
11750763	0	Leucine	0,7	SS-A/Ro	32,39	Leucine	SS-A/Ro	CHEBI:25017	6737	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Leucine zipper domain of 52 kDa SS-A/Ro promotes protein dimer formation and inhibits in vitro transcription activity .
27010498	0	Leucine	0,7	Sestrin2	37,45	Leucine	Sestrin2	CHEBI:25017	83667	Chemical	Gene	dephosphorylation|amod|START_ENTITY dephosphorylation|nmod|END_ENTITY	Leucine induced dephosphorylation of Sestrin2 promotes mTORC1 activation .
9435518	0	Leucine	0,7	TNF-alpha	22,31	Leucine	TNF-alpha	CHEBI:25017	24835(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|nmod|END_ENTITY	Leucine metabolism in TNF-alpha - and endotoxin-treated rats : contribution of hepatic tissue .
9061419	0	Leucine	0,7	aminopeptidase	8,22	Leucine	aminopeptidase	CHEBI:25017	10404	Chemical	Gene	enzymuria|amod|START_ENTITY enzymuria|compound|END_ENTITY	Leucine aminopeptidase enzymuria : quantification of renal tubular_damage following extracorporeal shock wave lithotripsy .
909874	0	Leucine	0,7	aminopeptidase	8,22	Leucine	aminopeptidase	CHEBI:25017	397520(Tax:9823)	Chemical	Gene	purification|dep|START_ENTITY purification|dep|END_ENTITY	Leucine aminopeptidase from swine kidney : purification , molecular weight , subunit and amino_acid composition .
8713290	0	Leucine	0,7	enkephalin	8,18	Leucine	enkephalin	CHEBI:25017	29237(Tax:10116)	Chemical	Gene	level|amod|START_ENTITY level|compound|END_ENTITY	Leucine enkephalin level in rat hypothalamus , striatum , hippocampus and adrenal glands in experimental rat uremia .
2645788	0	Leucine	0,7	insulin	46,53	Leucine	insulin	CHEBI:25017	3630	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|dep|effect effect|nmod|availability availability|compound|END_ENTITY	Leucine metabolism in aging humans : effect of insulin and substrate availability .
6137307	0	Leucine	0,7	insulin	78,85	Leucine	insulin	CHEBI:25017	3630	Chemical	Gene	uptake|amod|START_ENTITY uptake|dep|independence independence|nmod|levels levels|compound|END_ENTITY	Leucine uptake by splanchnic and leg tissues in man : relative independence of insulin levels .
8214049	0	Leucine	0,7	insulin	57,64	Leucine	insulin	CHEBI:25017	3630	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|dep|effect effect|nmod|availability availability|compound|END_ENTITY	Leucine metabolism in lactating and dry goats : effect of insulin and substrate availability .
8500731	0	Leucine	0,7	insulin	78,85	Leucine	insulin	CHEBI:25017	3630	Chemical	Gene	kinetics|compound|START_ENTITY kinetics|dep|effects effects|nmod|END_ENTITY	Leucine and phenylalanine kinetics in compensated liver_cirrhosis : effects of insulin .
20151325	0	Leucine	0,7	leptin_receptor	17,32	Leucine	leptin receptor	CHEBI:25017	16847(Tax:10090)	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|compound|END_ENTITY	Leucine promotes leptin_receptor expression in mouse C2C12 myotubes through the mTOR pathway .
16772439	0	Leucine	0,7	mTOR	78,82	Leucine	mTOR	CHEBI:25017	21977(Tax:10090)	Chemical	Gene	activates|nsubj|START_ENTITY activates|nmod|END_ENTITY	Leucine activates pancreatic translational machinery in rats and mice through mTOR independently of CCK and insulin .
17425063	0	Leucine	0,7	mTOR	31,35	Leucine	mTOR	CHEBI:25017	21977(Tax:10090)	Chemical	Gene	synthesis|compound|START_ENTITY synthesis|dep|END_ENTITY	Leucine and protein synthesis : mTOR and beyond .
17466941	0	Leucine	0,7	mTOR	68,72	Leucine	mTOR	CHEBI:25017	21977(Tax:10090)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|pathway pathway|compound|END_ENTITY	Leucine stimulates HGF production by hepatic stellate cells through mTOR pathway .
19401455	0	Leucine	0,7	mTOR	128,132	Leucine	mTOR	CHEBI:25017	21977(Tax:10090)	Chemical	Gene	restriction|amod|START_ENTITY inhibits|nsubj|restriction inhibits|nmod|mechanisms mechanisms|nmod|END_ENTITY	Leucine restriction inhibits chondrocyte proliferation and differentiation through mechanisms both dependent and independent of mTOR signaling .
20151325	0	Leucine	0,7	mTOR	80,84	Leucine	mTOR	CHEBI:25017	21977(Tax:10090)	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|pathway pathway|compound|END_ENTITY	Leucine promotes leptin_receptor expression in mouse C2C12 myotubes through the mTOR pathway .
21773813	0	Leucine	0,7	mTOR	41,45	Leucine	mTOR	CHEBI:25017	21977(Tax:10090)	Chemical	Gene	nutrition|amod|START_ENTITY nutrition|dep|END_ENTITY	Leucine nutrition in animals and humans : mTOR signaling and beyond .
22645144	0	Leucine	0,7	mTOR	118,122	Leucine	mTOR	CHEBI:25017	21977(Tax:10090)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|pathway pathway|amod|END_ENTITY	Leucine stimulates insulin secretion via down-regulation of surface expression of adrenergic a2A receptor through the mTOR -LRB- mammalian_target_of_rapamycin -RRB- pathway : implication in new-onset diabetes in renal transplantation .
22648621	0	Leucine	0,7	mTOR	83,87	Leucine	mTOR	CHEBI:25017	21977(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|control control|amod|dependent dependent|amod|END_ENTITY	Leucine induces myofibrillar protein accretion in cultured skeletal muscle through mTOR dependent and - independent control of myosin heavy chain mRNA levels .
26055918	0	Leucine	0,7	mTOR	107,111	Leucine	mTOR	CHEBI:25017	21977(Tax:10090)	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|synthesis synthesis|nmod|cells cells|nmod|END_ENTITY	Leucine and histidine independently regulate milk protein synthesis in bovine mammary epithelial cells via mTOR signaling pathway .
26334346	0	Leucine	0,7	mTOR	85,89	Leucine	mTOR	CHEBI:25017	21977(Tax:10090)	Chemical	Gene	supplementation|amod|START_ENTITY enhances|nsubj|supplementation enhances|dobj|activation activation|compound|END_ENTITY	Leucine supplementation of a chronically restricted protein and energy diet enhances mTOR pathway activation but not muscle protein synthesis in neonatal pigs .
18682538	0	Leucine	0,7	mTORC1	86,92	Leucine	mTORC1	CHEBI:25017	382056(Tax:10090)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|advcl|enhancing enhancing|dobj|activation activation|amod|END_ENTITY	Leucine stimulates protein synthesis in skeletal muscle of neonatal pigs by enhancing mTORC1 activation .
24806638	0	Leucine	0,7	mTORC1	116,122	Leucine	mTORC1	CHEBI:25017	382056(Tax:10090)	Chemical	Gene	facilitates|nsubj|START_ENTITY facilitates|dobj|uptake uptake|nmod|END_ENTITY	Leucine facilitates the insulin-stimulated glucose uptake and insulin signaling in skeletal muscle cells : involving mTORC1 and mTORC2 .
26007333	0	Leucine	0,7	mTORC1	106,112	Leucine	mTORC1	CHEBI:25017	382056(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|Pathway Pathway|amod|END_ENTITY	Leucine Promotes Proliferation and Differentiation of Primary Preterm Rat Satellite Cells in Part through mTORC1 Signaling Pathway .
26007333	0	Leucine	0,7	mTORC1	106,112	Leucine	mTORC1	CHEBI:25017	382056(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|Pathway Pathway|amod|END_ENTITY	Leucine Promotes Proliferation and Differentiation of Primary Preterm Rat Satellite Cells in Part through mTORC1 Signaling Pathway .
27010498	0	Leucine	0,7	mTORC1	55,61	Leucine	mTORC1	CHEBI:25017	382056(Tax:10090)	Chemical	Gene	dephosphorylation|amod|START_ENTITY promotes|nsubj|dephosphorylation promotes|dobj|activation activation|amod|END_ENTITY	Leucine induced dephosphorylation of Sestrin2 promotes mTORC1 activation .
17178807	0	Leucine	0,7	mammalian_target_of_rapamycin	19,48	Leucine	mammalian target of rapamycin	CHEBI:25017	2475	Chemical	Gene	stimulates|amod|START_ENTITY END_ENTITY|nsubj|stimulates	Leucine stimulates mammalian_target_of_rapamycin signaling in C2C12 myoblasts in part through inhibition of adenosine_monophosphate-activated protein kinase .
18435829	0	Leucine	0,7	p70S6K	50,56	Leucine	p70S6K	CHEBI:25017	6198	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Leucine induces phosphorylation and activation of p70S6K in cortical neurons via the system L amino_acid transporter .
1676997	0	Leuhistin	0,9	aminopeptidase_M	30,46	Leuhistin	aminopeptidase M	MESH:C069912	290	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Leuhistin , a new inhibitor of aminopeptidase_M , produced by Bacillus laterosporus BMI156-14F1 .
1676998	0	Leuhistin	0,9	aminopeptidase_M	30,46	Leuhistin	aminopeptidase M	MESH:C069912	290	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Leuhistin , a new inhibitor of aminopeptidase_M , produced by Bacillus laterosporus BMI156-14F1 .
7653518	0	Leukoregulin	0,12	plasminogen_activator_inhibitor_type_1	21,59	Leukoregulin	plasminogen activator inhibitor type 1	MESH:C044162	5054	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Leukoregulin induces plasminogen_activator_inhibitor_type_1 in human orbital fibroblasts .
15358656	0	Leukotriene_B4	0,14	BLT-1	25,30	Leukotriene B4	BLT-1	MESH:D007975	16995(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Leukotriene_B4 receptor -LRB- BLT-1 -RRB- modulates neutrophil influx into the peritoneum but not the lung and liver during surgically induced bacterial_peritonitis in mice .
16293697	0	Leukotriene_B4	0,14	BLT1	53,57	Leukotriene B4	BLT1	MESH:D007975	1241	Chemical	Gene	START_ENTITY|acl|signaling signaling|nmod|receptors receptors|compound|END_ENTITY	Leukotriene_B4 signaling through NF-kappaB-dependent BLT1 receptors on vascular smooth_muscle_cells in atherosclerosis and intimal hyperplasia .
26527063	0	Leukotriene_B4	0,14	BLT2	32,36	Leukotriene B4	BLT2	MESH:D007975	57260(Tax:10090)	Chemical	Gene	type|amod|START_ENTITY type|appos|END_ENTITY	Leukotriene_B4 receptor type 2 -LRB- BLT2 -RRB- enhances skin barrier function by regulating tight junction proteins .
1313226	0	Leukotriene_B4	0,14	c-fos	26,31	Leukotriene B4	c-fos	MESH:D007975	2353	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Leukotriene_B4 stimulates c-fos and c-jun gene transcription and AP-1 binding activity in human monocytes .
9398088	0	Leukotriene_B4	0,14	cytosolic_phospholipase_A2	93,119	Leukotriene B4	cytosolic phospholipase A2	MESH:D007975	5321	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|neutrophils neutrophils|nmod|action action|nmod|END_ENTITY	Leukotriene_B4 stimulates the release of arachidonate in human neutrophils via the action of cytosolic_phospholipase_A2 .
1323342	0	Leukotriene_B4	0,14	interleukin-6	24,37	Leukotriene B4	interleukin-6	MESH:D007975	3569	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|amod|END_ENTITY	Leukotriene_B4 enhances interleukin-6 -LRB- IL-6 -RRB- production and IL-6 messenger RNA accumulation in human monocytes in vitro : transcriptional and posttranscriptional mechanisms .
1327803	0	Leukotriene_B4	0,14	interleukin-6	43,56	Leukotriene B4	interleukin-6	MESH:D007975	3569	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|amod|END_ENTITY	Leukotriene_B4 transcriptionally activates interleukin-6 expression involving NK-chi B and NF-IL6 .
18565553	0	Leukotriene_C4	0,14	IL-8	47,51	Leukotriene C4	IL-8	MESH:D017997	396880(Tax:9823)	Chemical	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	Leukotriene_C4 release and gene expressions of IL-8 and MCP-1 in porcine alveolar epithelial type II cells .
16179583	0	Leukotriene_C4	0,14	TGF-beta1	23,32	Leukotriene C4	TGF-beta1	MESH:D017997	7040	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|compound|END_ENTITY	Leukotriene_C4 induces TGF-beta1 production in airway epithelium via p38 kinase pathway .
8997273	0	Leukotriene_D4	0,14	MMP-1	23,28	Leukotriene D4	MMP-1	MESH:D017998	4312	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Leukotriene_D4 induces MMP-1 , which functions as an IGFBP protease in human airway_smooth_muscle cells .
18323532	0	Leukotriene_D4	0,14	furin	28,33	Leukotriene D4	furin	MESH:D017998	5045	Chemical	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|compound|END_ENTITY	Leukotriene_D4 up-regulates furin expression through CysLT1 receptor signaling .
12071848	0	Leukotriene_D4	0,14	phospholipase_C-gamma1	55,77	Leukotriene D4	phospholipase C-gamma1	MESH:D017998	5335	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Leukotriene_D4 induces association of active RhoA with phospholipase_C-gamma1 in intestinal epithelial cells .
15947480	0	Leukotriene_D4	0,14	transforming_growth_factor-beta1	37,69	Leukotriene D4	transforming growth factor-beta1	MESH:D017998	7040	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|nmod|END_ENTITY	Leukotriene_D4 induces production of transforming_growth_factor-beta1 by eosinophils .
21482134	0	Leukotriene_D4	0,14	vascular_endothelial_growth_factor	56,90	Leukotriene D4	vascular endothelial growth factor	MESH:D017998	7422	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|compound|END_ENTITY	Leukotriene_D4 enhances tumor_necrosis_factor-a-induced vascular_endothelial_growth_factor production in human monocytes/macrophages .
8685049	0	Leuprolelin	33,44	luteinizing_hormone-releasing_hormone	48,85	Leuprolelin	luteinizing hormone-releasing hormone	null	25194(Tax:10116)	Chemical	Gene	START_ENTITY|appos|analog analog|amod|END_ENTITY	Influence of diethylstilbestrol , Leuprolelin -LRB- a luteinizing_hormone-releasing_hormone analog -RRB- , Finasteride -LRB- a 5 alpha-reductase inhibitor -RRB- , and castration on the lobar subdivisions of the rat prostate .
18068102	0	Leuprolide	0,10	GnRH	14,18	Leuprolide	GnRH	MESH:D016729	14714(Tax:10090)	Chemical	Gene	START_ENTITY|dep|agonist agonist|amod|END_ENTITY	Leuprolide -- a GnRH agonist -- prevents restraint stress-induced immunosuppression via sex steroid-independent peripheral mechanism in mice .
2429815	0	Leuprolide	0,10	gonadotropin-releasing_hormone	14,44	Leuprolide	gonadotropin-releasing hormone	MESH:D016729	2796	Chemical	Gene	START_ENTITY|dep|analog analog|amod|END_ENTITY	Leuprolide : a gonadotropin-releasing_hormone analog for the palliative treatment of prostatic_cancer .
9839481	0	Leuprolide	0,10	gonadotropin-releasing_hormone	14,44	Leuprolide	gonadotropin-releasing hormone	MESH:D016729	14714(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Leuprolide , a gonadotropin-releasing_hormone agonist , enhances colonization after spermatogonial transplantation into mouse testes .
22832949	0	Leuprolide_acetate	0,18	GnRH	22,26	Leuprolide acetate	GnRH	MESH:D016729	25194(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Leuprolide_acetate , a GnRH agonist , improves experimental_autoimmune_encephalomyelitis : a possible therapy for multiple_sclerosis .
26927633	0	Levetiracetam	30,43	Aquaporin_4	47,58	Levetiracetam	Aquaporin 4	MESH:C026098	25293(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|Expression Expression|compound|END_ENTITY	Effects of Different Doses of Levetiracetam on Aquaporin_4 Expression in Rats with Brain_Edema Following Fluid Percussion Injury .
24600432	0	Levetiracetam	0,13	CD95	36,40	Levetiracetam	CD95	MESH:C026098	355	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Levetiracetam Differentially Alters CD95 Expression of Neuronal Cells and the Mitochondrial Membrane Potential of Immune and Neuronal Cells in vitro .
12763257	0	Levetiracetam	137,150	brain-derived_neurotrophic_factor	14,47	Levetiracetam	brain-derived neurotrophic factor	MESH:C026098	24225(Tax:10116)	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|Expression Expression|nmod|END_ENTITY	Expression of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- and inducible_nitric_oxide_synthase -LRB- iNOS -RRB- in rat astrocyte cultures treated with Levetiracetam .
25017707	0	Levobupivacaine	0,15	high_mobility_group_box_1	52,77	Levobupivacaine	high mobility group box 1	MESH:C476513	15289(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|amod|END_ENTITY	Levobupivacaine inhibits lipopolysaccharide-induced high_mobility_group_box_1 release in vitro and in vivo .
19110001	0	Levocetirizine	0,14	ICAM-1	43,49	Levocetirizine	ICAM-1	MESH:C472067	3383	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Levocetirizine inhibits rhinovirus-induced ICAM-1 and cytokine expression and viral replication in airway epithelial cells .
21757851	0	Levormeloxifene	0,15	tropoelastin	33,45	Levormeloxifene	tropoelastin	MESH:C108255	2006	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Levormeloxifene inhibits vaginal tropoelastin and transforming_growth_factor_beta_1 production .
26528797	0	Levosimendan	0,12	Akt	77,80	Levosimendan	Akt	MESH:C076731	24185(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|activation activation|nmod|END_ENTITY	Levosimendan inhibits interleukin-1b-induced apoptosis through activation of Akt and inhibition of inducible nitric_oxide synthase in rat cardiac fibroblasts .
15771921	0	Levosimendan	0,12	B-type_natriuretic_peptide	28,54	Levosimendan	B-type natriuretic peptide	MESH:C076731	4879	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|plasma plasma|amod|END_ENTITY	Levosimendan reduces plasma B-type_natriuretic_peptide and interleukin_6 , and improves central hemodynamics in severe heart_failure patients .
10599717	0	Levothyroxine	0,13	thyroglobulin	29,42	Levothyroxine	thyroglobulin	MESH:D013974	7038	Chemical	Gene	suppression|amod|START_ENTITY suppression|nmod|END_ENTITY	Levothyroxine suppression of thyroglobulin in patients with differentiated_thyroid_carcinoma .
23941178	0	Lewis_acid	13,23	CO2	62,65	Lewis acid	CO2	CHEBI:39143	717	Chemical	Gene	START_ENTITY|nmod|reduction reduction|nmod|END_ENTITY	Roles of the Lewis_acid and base in the chemical reduction of CO2 catalyzed by frustrated Lewis_pairs .
19367569	0	Li-Fraumeni	0,11	p53	55,58	Li-Fraumeni	p53	null	7157	Chemical	Gene	mutations|amod|START_ENTITY mutations|nmod|END_ENTITY	Li-Fraumeni and Li-Fraumeni-like_syndrome mutations in p53 are associated with exonic methylation and splicing regulatory elements .
21504119	0	LiCl	0,4	GSK-3b	76,82	LiCl	GSK-3b	CHEBI:48607	2932	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|advcl|inhibiting inhibiting|dobj|END_ENTITY	LiCl attenuates thapsigargin-induced tau_hyperphosphorylation by inhibiting GSK-3b in vivo and in vitro .
25412347	0	LiCl	27,31	Interleukin_6	97,110	LiCl	Interleukin 6	CHEBI:48607	3569	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|Production Production|compound|END_ENTITY	The Combination Effects of LiCl and the Active Leflunomide Metabolite , A771726 , on Viral-Induced Interleukin_6 Production and EV-A71 Replication .
25535091	0	LiCl	24,28	PPT	15,18	LiCl	PPT	D018021	24806(Tax:10116)	Chemical	Gene	Treatment|compound|START_ENTITY END_ENTITY|nmod|Treatment	Combination of PPT with LiCl Treatment Prevented Bilateral Ovariectomy-Induced Hippocampal-Dependent Cognition Deficit in Rats .
20117981	0	Lianggesan	11,21	signal_transducer_and_activator_of_transcription_1	43,93	Lianggesan	signal transducer and activator of transcription 1	null	25124(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of Lianggesan on the expression of signal_transducer_and_activator_of_transcription_1 in a rat model of lipopolysaccharide-induced acute_lung_injury -RSB- .
24825427	0	Liarozole	0,9	transforming_growth_factor-b3	19,48	Liarozole	transforming growth factor-b3	MESH:C061121	7043	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Liarozole inhibits transforming_growth_factor-b3 -- mediated extracellular matrix formation in human three-dimensional leiomyoma cultures .
25710724	0	Licochalcone_A	0,14	COX-2	72,77	Licochalcone A	COX-2	MESH:C070840	4513	Chemical	Gene	Suppresses|nsubj|START_ENTITY Suppresses|dobj|Expression Expression|compound|END_ENTITY	Licochalcone_A , a Polyphenol Present in Licorice , Suppresses UV-Induced COX-2 Expression by Targeting PI3K , MEK1 , and B-Raf .
25381913	0	Licochalcone_A	0,14	Nrf2	25,29	Licochalcone A	Nrf2	MESH:C070840	4780	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Licochalcone_A activates Nrf2 in vitro and contributes to licorice extract-induced lowered cutaneous oxidative stress in vivo .
25586190	0	Licochalcone_A	0,14	Sp1	93,96	Licochalcone A	Sp1	MESH:C070840	6667	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|downregulation downregulation|nmod|END_ENTITY	Licochalcone_A induces apoptosis in malignant_pleural_mesothelioma through downregulation of Sp1 and subsequent activation of mitochondria-related apoptotic pathway .
24253317	0	Licochalcone_A	0,14	c-Jun_N-terminal_kinase_1	39,64	Licochalcone A	c-Jun N-terminal kinase 1	MESH:C070840	26419(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Licochalcone_A , a natural inhibitor of c-Jun_N-terminal_kinase_1 .
22480685	0	Lidamycin	0,9	Oct4	124,128	Lidamycin	Oct4	MESH:C058024	100846986	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|down-regulation down-regulation|nmod|END_ENTITY	Lidamycin induces neural differentiation of mouse embryonic_carcinoma cells through down-regulation of transcription factor Oct4 .
24709078	0	Lidamycin	0,9	Oct4	49,53	Lidamycin	Oct4	MESH:C058024	100846986	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|advcl|repressing repressing|dobj|transcription transcription|amod|END_ENTITY	Lidamycin regulates p53 expression by repressing Oct4 transcription .
24709078	0	Lidamycin	0,9	p53	20,23	Lidamycin	p53	MESH:C058024	22060(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Lidamycin regulates p53 expression by repressing Oct4 transcription .
25312651	0	Lidocaine	0,9	IL-10	51,56	Lidocaine	IL-10	MESH:D008012	16153(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Lidocaine increases the anti-inflammatory cytokine IL-10 following mechanical ventilation in healthy mice .
11876744	0	Lidocaine	0,9	IL-8	32,36	Lidocaine	IL-8	MESH:D008012	3576	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|nmod|END_ENTITY	Lidocaine inhibits secretion of IL-8 and IL-1beta and stimulates secretion of IL-1_receptor_antagonist by epithelial cells .
14570645	0	Lidocaine	0,9	monocyte_chemoattractant_protein-1	21,55	Lidocaine	monocyte chemoattractant protein-1	MESH:D008012	6347	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|production production|amod|END_ENTITY	Lidocaine attenuates monocyte_chemoattractant_protein-1 production and chemotaxis in human monocytes : possible mechanisms for its effect on inflammation .
1280232	0	Lidocaine	0,9	prolactin	19,28	Lidocaine	prolactin	MESH:D008012	24683(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|compound|END_ENTITY	Lidocaine inhibits prolactin secretion in GH4C1 cells by blocking calcium influx .
21457761	0	Ligustilide	0,11	iNOS	33,37	Ligustilide	iNOS	MESH:C027820	4843	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|dobj|expression expression|compound|END_ENTITY	Ligustilide prevents LPS-induced iNOS expression in RAW 264.7 macrophages by preventing ROS production and down-regulating the MAPK , NF-kB and AP-1 signaling pathways .
22702057	0	Ligustrazine	11,23	FoXO3a	42,48	Ligustrazine	FoXO3a	MESH:C017953	294515(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expressions expressions|nmod|END_ENTITY	-LSB- Effect of Ligustrazine on expressions of FoXO3a , MAFbx , and MuRF1 in denervated skeletal muscle_atrophy rats -RSB- .
15015632	0	Ligustrazine	15,27	bFGF	49,53	Ligustrazine	bFGF	MESH:C017953	14173(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of Ligustrazine on the expression of bFGF and bFGFR in bone marrow in radiation injured mice .
20307554	0	Linaclotide	0,11	guanylate_cyclase_C	38,57	Linaclotide	guanylate cyclase C	MESH:C523483	14917(Tax:10090)	Chemical	Gene	agonist|nsubj|START_ENTITY agonist|amod|END_ENTITY	Linaclotide is a potent and selective guanylate_cyclase_C agonist that elicits pharmacological effects locally in the gastrointestinal tract .
19947894	4	Linagliptin	623,634	DPP-4	693,698	Linagliptin	DPP-4	MESH:C568794	1803	Chemical	Gene	belongs|nsubj|START_ENTITY belongs|nmod|class class|nmod|inhibitors inhibitors|appos|END_ENTITY	Linagliptin belongs to a new chemical class of dipeptidyl_pepidase-4 -LRB- DPP-4 -RRB- inhibitors , which comprise xanthine-based compounds .
21059094	0	Linagliptin	0,11	DPP-4	46,51	Linagliptin	DPP-4	MESH:C568794	1803	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Linagliptin -LRB- BI_1356 -RRB- , a potent and selective DPP-4 inhibitor , is safe and efficacious in combination with metformin in patients with inadequately controlled Type 2 diabetes .
21680988	0	Linagliptin	0,11	DPP-4	19,24	Linagliptin	DPP-4	MESH:C568794	1803	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Linagliptin : a new DPP-4 inhibitor for the treatment of type_2_diabetes_mellitus .
22482239	0	Linagliptin	1,12	DPP-4	37,42	Linagliptin	DPP-4	MESH:C568794	1803	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	-LSB- Linagliptin -LRB- Trajenta -RRB- : a selective DPP-4 inhibitor with limited renal elimination -RSB- .
26010513	0	Linagliptin	16,27	DPP-4	0,5	Linagliptin	DPP-4	MESH:C568794	1803	Chemical	Gene	Cytotoxicity|compound|START_ENTITY Cytotoxicity|compound|END_ENTITY	DPP-4 Inhibitor Linagliptin Attenuates Ab-induced Cytotoxicity through Activation of AMPK in Neuronal Cells .
26826382	0	Linagliptin	0,11	DPP-4	92,97	Linagliptin	DPP-4	MESH:C568794	1803	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|xcomp|transforming transforming|dobj|activity activity|compound|END_ENTITY	Linagliptin but not Sitagliptin inhibited transforming growth factor-b2-induced endothelial DPP-4 activity and the endothelial-mesenchymal transition .
26618855	0	Linagliptin	37,48	Dipeptidyl_Peptidase-4	4,26	Linagliptin	Dipeptidyl Peptidase-4	MESH:C568794	25253(Tax:10116)	Chemical	Gene	Function|compound|START_ENTITY END_ENTITY|dep|Function	The Dipeptidyl_Peptidase-4 Inhibitor Linagliptin Preserves Endothelial Function in Mesenteric Arteries from Type 1 Diabetic Rats without Decreasing Plasma Glucose .
19777398	0	Linagliptin	0,11	dipeptidyl_peptidase-4	15,37	Linagliptin	dipeptidyl peptidase-4	MESH:C568794	1803	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Linagliptin , a dipeptidyl_peptidase-4 inhibitor for the treatment of type 2 diabetes .
19947894	0	Linagliptin	0,11	dipeptidyl_peptidase-4	30,52	Linagliptin	dipeptidyl peptidase-4	MESH:C568794	1803	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Linagliptin , a xanthine-based dipeptidyl_peptidase-4 inhibitor with an unusual profile for the treatment of type 2 diabetes .
20637971	0	Linagliptin	0,11	dipeptidyl_peptidase-4	15,37	Linagliptin	dipeptidyl peptidase-4	MESH:C568794	1803	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Linagliptin , a dipeptidyl_peptidase-4 inhibitor in development for the treatment of type_2_diabetes_mellitus : a Phase I , randomized , double-blind , placebo-controlled trial of single and multiple escalating doses in healthy adult male Japanese subjects .
22143285	0	Linagliptin	0,11	dipeptidyl_peptidase-4	24,46	Linagliptin	dipeptidyl peptidase-4	MESH:C568794	1803	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Linagliptin : the newest dipeptidyl_peptidase-4 inhibitor for type_2_diabetes_mellitus .
22149370	0	Linagliptin	0,11	dipeptidyl_peptidase-4	15,37	Linagliptin	dipeptidyl peptidase-4	MESH:C568794	1803	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Linagliptin , a dipeptidyl_peptidase-4 inhibitor with a unique pharmacological profile , and efficacy in a broad range of patients with type 2 diabetes .
22420306	0	Linagliptin	0,11	dipeptidyl_peptidase-4	50,72	Linagliptin	dipeptidyl peptidase-4	MESH:C568794	1803	Chemical	Gene	START_ENTITY|dep|methylxanthin methylxanthin|acl|based based|dobj|inhibitor inhibitor|amod|END_ENTITY	Linagliptin : a novel methylxanthin based approved dipeptidyl_peptidase-4 inhibitor .
21603986	0	Linagliptin	0,11	dipeptidyl_peptidase_4	21,43	Linagliptin	dipeptidyl peptidase 4	MESH:C568794	1803	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Linagliptin : a novel dipeptidyl_peptidase_4 inhibitor with a unique place in therapy .
25767681	0	Linoleic_Acid	66,79	ATF3	0,4	Linoleic Acid	ATF3	MESH:D019787	467	Chemical	Gene	Activity|nmod|START_ENTITY Activity|compound|END_ENTITY	ATF3 Mediates Anti-Cancer Activity of Trans-10 , cis-12-Conjugated Linoleic_Acid in Human Colon_Cancer Cells .
26879142	0	Linoleic_acid	0,13	AgRP	58,62	Linoleic acid	AgRP	MESH:D019787	11604(Tax:10090)	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|expression expression|compound|END_ENTITY	Linoleic_acid and stearic_acid elicit opposite effects on AgRP expression and secretion via TLR4-dependent signaling pathways in immortalized hypothalamic N38 cells .
2083720	0	Linoleic_acid	0,13	Ca2	34,37	Linoleic acid	Ca2	MESH:D019787	760	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|+ +|amod|END_ENTITY	Linoleic_acid increases cytosolic Ca2 + in lymphocytes .
12031258	0	Linoleic_acid	0,13	MCP-1	22,27	Linoleic acid	MCP-1	MESH:D019787	6347	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Linoleic_acid induces MCP-1 gene expression in human microvascular endothelial cells through an oxidative mechanism .
8602587	0	Linoleic_acid	0,13	nuclear_transcription_factor-kappa_B	24,60	Linoleic acid	nuclear transcription factor-kappa B	MESH:D019787	4790	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Linoleic_acid activates nuclear_transcription_factor-kappa_B -LRB- NF-kappa_B -RRB- and induces NF-kappa_B-dependent transcription in cultured endothelial cells .
17067544	0	Linoleoyl_lysophosphatidylcholine	0,33	lipoxygenase-1	72,86	Linoleoyl lysophosphatidylcholine	lipoxygenase-1	null	547923(Tax:3847)	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Linoleoyl_lysophosphatidylcholine is an efficient substrate for soybean lipoxygenase-1 .
9808084	0	Linoleyl_hydroperoxide	0,22	heme_oxygenase-1	53,69	Linoleyl hydroperoxide	heme oxygenase-1	null	3162	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Linoleyl_hydroperoxide transcriptionally upregulates heme_oxygenase-1 gene expression in human renal epithelial and aortic endothelial cells .
15492015	0	Linomide	49,57	Interleukin-10	0,14	Linomide	Interleukin-10	MESH:C045282	16153(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY mediates|dobj|effect mediates|nsubj|END_ENTITY	Interleukin-10 mediates the protective effect of Linomide by reducing CXC chemokine production in endotoxin-induced liver_injury .
8921440	0	Linomide	0,8	Th1	43,46	Linomide	Th1	MESH:C045282	51497	Chemical	Gene	cytokine|advmod|START_ENTITY cytokine|nsubj|immunomodulator immunomodulator|acl:relcl|inhibits inhibits|dobj|END_ENTITY	Linomide , an immunomodulator that inhibits Th1 cytokine gene expression .
9058774	0	Linomide	0,8	Th1	25,28	Linomide	Th1	MESH:C045282	51497	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|ccomp|cytokines cytokines|nsubj|END_ENTITY	Linomide suppresses both Th1 and Th2 cytokines in experimental autoimmune myasthenia_gravis .
9688338	0	Linomide	44,52	Th1	28,31	Linomide	Th1	MESH:C045282	57314(Tax:10090)	Chemical	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Selective downregulation of Th1 response by Linomide reduces autoimmunity but increases susceptibility to viral_infection in BALB/c and SJL mice .
10064056	0	Lipid_A	0,7	IL-4	26,30	Lipid A	IL-4	MESH:D008050	16189(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	Lipid_A directly inhibits IL-4 production by murine Th2 cells but does not inhibit IFN-gamma production by Th1 cells .
19215222	0	Lipid_phosphate	0,15	LPP1	41,45	Lipid phosphate	LPP1	null	19012(Tax:10090)	Chemical	Gene	type|amod|START_ENTITY type|appos|END_ENTITY	Lipid_phosphate phosphohydrolase type 1 -LRB- LPP1 -RRB- degrades extracellular lysophosphatidic_acid in vivo .
18562016	0	Lipoic_acid	0,11	EP2	47,50	Lipoic acid	EP2	MESH:D008063	5732	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|nmod|END_ENTITY	Lipoic_acid stimulates cAMP production via the EP2 and EP4 prostanoid receptors and inhibits IFN_gamma synthesis and cellular cytotoxicity in NK cells .
21315065	0	Lipoic_acid	0,11	HO-1	49,53	Lipoic acid	HO-1	MESH:D008063	3162	Chemical	Gene	ameliorates|nsubj|START_ENTITY ameliorates|dobj|expression expression|compound|END_ENTITY	Lipoic_acid ameliorates arsenic_trioxide-induced HO-1 expression and oxidative stress in THP-1 monocytes and macrophages .
16644024	0	Lipoic_acid	0,11	ICAM-1	35,41	Lipoic acid	ICAM-1	MESH:D008063	15894(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Lipoic_acid inhibits expression of ICAM-1 and VCAM-1 by CNS endothelial cells and T cell migration into the spinal cord in experimental_autoimmune_encephalomyelitis .
26063499	0	Lipoic_acid	0,11	Mcl-1	22,27	Lipoic acid	Mcl-1	MESH:D008063	4170	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|END_ENTITY	Lipoic_acid decreases Mcl-1 , Bcl-xL and up regulates Bim on ovarian_carcinoma cells leading to cell death .
26904958	0	Lipoic_acid	0,11	Nrf2	95,99	Lipoic acid	Nrf2	MESH:D008063	83619(Tax:10116)	Chemical	Gene	improve|nsubj|START_ENTITY improve|nmod|model model|dep|role role|nmod|inactivation inactivation|amod|END_ENTITY	Lipoic_acid does not improve renal function markers in 5/6 nephrectomy model : possible role of Nrf2 inactivation .
23307774	0	Lipoic_acid	0,11	adiponectin	21,32	Lipoic acid	adiponectin	MESH:D008063	9370	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	Lipoic_acid inhibits adiponectin production in 3T3-L1 adipocytes .
14687728	0	Lipopolysaccharide	0,18	4-1BB_ligand	42,54	Lipopolysaccharide	4-1BB ligand	CHEBI:16412	8744	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Lipopolysaccharide preferentially induces 4-1BB_ligand expression on human monocyte-derived dendritic cells .
14642780	0	Lipopolysaccharide	0,18	Akt	29,32	Lipopolysaccharide	Akt	CHEBI:16412	207	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Lipopolysaccharide activates Akt in vascular smooth muscle cells resulting in induction of inducible nitric_oxide synthase through nuclear_factor-kappa_B activation .
18182168	0	Lipopolysaccharide	0,18	Akt	138,141	Lipopolysaccharide	Akt	CHEBI:16412	207	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|cells cells|dep|involvement involvement|nmod|END_ENTITY	Lipopolysaccharide induces VCAM-1 expression and neutrophil adhesion to human tracheal smooth muscle cells : involvement of Src/EGFR/PI3-K / Akt pathway .
20458734	0	Lipopolysaccharide	0,18	BIRC2	45,50	Lipopolysaccharide	BIRC2	CHEBI:16412	329	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Lipopolysaccharide induces autophagy through BIRC2 in human umbilical vein endothelial cells .
10448100	0	Lipopolysaccharide	0,18	Cla-1	69,74	Lipopolysaccharide	Cla-1	CHEBI:16412	949	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Lipopolysaccharide inhibits the expression of the scavenger receptor Cla-1 in human monocytes and macrophages .
11997234	0	Lipopolysaccharide	0,18	ERK1/2	34,40	Lipopolysaccharide	ERK1/2	CHEBI:16412	26417;26413	Chemical	Gene	stimulation|amod|START_ENTITY stimulation|nmod|END_ENTITY	Lipopolysaccharide stimulation of ERK1/2 increases TNF-alpha production via Egr-1 .
17149706	0	Lipopolysaccharide	0,18	ERK1/2	122,128	Lipopolysaccharide	ERK1/2	CHEBI:16412	26417;26413	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|coupling coupling|nmod|cells cells|acl|targeting targeting|dep|END_ENTITY	Lipopolysaccharide reduces electrical coupling in microvascular endothelial cells by targeting connexin40 in a tyrosine - , ERK1/2 - , PKA - , and PKC-dependent manner .
19328847	0	Lipopolysaccharide	0,18	Fos	52,55	Lipopolysaccharide	Fos	CHEBI:16412	314322(Tax:10116)	Chemical	Gene	suppression|amod|START_ENTITY suppression|nmod|END_ENTITY	Lipopolysaccharide challenge-induced suppression of Fos in hypothalamic orexin neurons : their potential role in sickness behavior .
15789431	0	Lipopolysaccharide	0,18	GLT-1	40,45	Lipopolysaccharide	GLT-1	CHEBI:16412	29482(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Lipopolysaccharide increases microglial GLT-1 expression and glutamate uptake capacity in vitro by a mechanism dependent on TNF-alpha .
24595367	0	Lipopolysaccharide	0,18	HDAC2	58,63	Lipopolysaccharide	HDAC2	CHEBI:16412	84577(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Lipopolysaccharide induces up-regulation of TGF-a through HDAC2 in a rat model of bronchopulmonary_dysplasia .
10710530	0	Lipopolysaccharide	0,18	ICAM-1	38,44	Lipopolysaccharide	ICAM-1	CHEBI:16412	25464(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Lipopolysaccharide induces functional ICAM-1 expression in rat alveolar epithelial cells in vitro .
26747779	0	Lipopolysaccharide	0,18	ICAM-1	27,33	Lipopolysaccharide	ICAM-1	D008070	3383	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Lipopolysaccharide induces ICAM-1 expression via a c-Src/NADPH oxidase/ROS-dependent NF-kB pathway in human pulmonary alveolar epithelial cells .
11823533	0	Lipopolysaccharide	0,18	IL-10	47,52	Lipopolysaccharide	IL-10	CHEBI:16412	3586	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|nmod|END_ENTITY	Lipopolysaccharide induces rapid production of IL-10 by monocytes in the presence of apoptotic neutrophils .
10395693	0	Lipopolysaccharide	0,18	IL-1_beta	141,150	Lipopolysaccharide	IL-1 beta	CHEBI:16412	3553	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	Lipopolysaccharide modulates cyclooxygenase-2 transcriptionally and posttranscriptionally in human macrophages independently from endogenous IL-1_beta and TNF-alpha .
21668365	0	Lipopolysaccharide	0,18	IP-10	50,55	Lipopolysaccharide	IP-10	CHEBI:16412	3627	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|compound|END_ENTITY	Lipopolysaccharide inhibits Sindbis_virus-induced IP-10 release in human peripheral blood mononuclear cells .
8505309	0	Lipopolysaccharide	0,18	MAD3	46,50	Lipopolysaccharide	MAD3	CHEBI:16412	4792	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Lipopolysaccharide induces phosphorylation of MAD3 and activation of c-Rel and related NF-kappa_B proteins in human monocytic THP-1 cells .
25172547	0	Lipopolysaccharide	0,18	MDM2	77,81	Lipopolysaccharide	MDM2	CHEBI:16412	17246(Tax:10090)	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|nmod|activation activation|nmod|END_ENTITY	Lipopolysaccharide downregulates the expression of p53 through activation of MDM2 and enhances activation of nuclear factor-kappa B .
22842850	0	Lipopolysaccharide	0,18	MMP-9	29,34	Lipopolysaccharide	MMP-9	CHEBI:16412	4318	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Lipopolysaccharide regulates MMP-9 expression through TLR4/NF-kB signaling in human arterial smooth muscle cells .
21941410	0	Lipopolysaccharide	0,18	P2X7_receptor	56,69	Lipopolysaccharide	P2X7 receptor	D008070	5027	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	Lipopolysaccharide inhibits the channel activity of the P2X7_receptor .
21970823	0	Lipopolysaccharide	0,18	S100B	40,45	Lipopolysaccharide	S100B	CHEBI:16412	25742(Tax:10116)	Chemical	Gene	modulates|amod|START_ENTITY modulates|dep|secretion secretion|compound|END_ENTITY	Lipopolysaccharide modulates astrocytic S100B secretion : a study in cerebrospinal fluid and astrocyte cultures from rats .
18182168	0	Lipopolysaccharide	0,18	VCAM-1	27,33	Lipopolysaccharide	VCAM-1	CHEBI:16412	7412	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Lipopolysaccharide induces VCAM-1 expression and neutrophil adhesion to human tracheal smooth muscle cells : involvement of Src/EGFR/PI3-K / Akt pathway .
18085354	0	Lipopolysaccharide	0,18	adipose_differentiation-related_protein	27,66	Lipopolysaccharide	adipose differentiation-related protein	CHEBI:16412	11520(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Lipopolysaccharide induces adipose_differentiation-related_protein expression and lipid accumulation in the liver through inhibition of fatty_acid oxidation in mice .
10889349	0	Lipopolysaccharide	0,18	arginine-vasopressin	29,49	Lipopolysaccharide	arginine-vasopressin	CHEBI:16412	24221(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|release release|amod|END_ENTITY	Lipopolysaccharide increases arginine-vasopressin release from rat suprachiasmatic nucleus slice cultures .
19027716	0	Lipopolysaccharide	0,18	autotaxin	27,36	Lipopolysaccharide	autotaxin	CHEBI:16412	5168	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Lipopolysaccharide induces autotaxin expression in human monocytic THP-1 cells .
9427712	0	Lipopolysaccharide	0,18	caspase-1	29,38	Lipopolysaccharide	caspase-1	CHEBI:16412	834	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Lipopolysaccharide activates caspase-1 -LRB- interleukin-1-converting enzyme -RRB- in cultured monocytic and endothelial cells .
12492453	0	Lipopolysaccharide	0,18	cholesterol_7-alpha_hydroxylase	29,60	Lipopolysaccharide	cholesterol 7-alpha hydroxylase	CHEBI:16412	25428(Tax:10116)	Chemical	Gene	represses|nsubj|START_ENTITY represses|xcomp|END_ENTITY	Lipopolysaccharide represses cholesterol_7-alpha_hydroxylase and induces binding activity to the bile_acid response element II .
21135542	0	Lipopolysaccharide	0,18	corticotropin-releasing_hormone	46,77	Lipopolysaccharide	corticotropin-releasing hormone	CHEBI:16412	81648(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|nmod|END_ENTITY	Lipopolysaccharide increases plasma levels of corticotropin-releasing_hormone in rats .
10395693	0	Lipopolysaccharide	0,18	cyclooxygenase-2	29,45	Lipopolysaccharide	cyclooxygenase-2	CHEBI:16412	5743	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|transcriptionally transcriptionally|amod|END_ENTITY	Lipopolysaccharide modulates cyclooxygenase-2 transcriptionally and posttranscriptionally in human macrophages independently from endogenous IL-1_beta and TNF-alpha .
16365453	0	Lipopolysaccharide	0,18	cyclooxygenase-2	27,43	Lipopolysaccharide	cyclooxygenase-2	CHEBI:16412	29527(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Lipopolysaccharide induces cyclooxygenase-2 in intestinal epithelium via a noncanonical p38 MAPK pathway .
19647233	0	Lipopolysaccharide	0,18	cyclooxygenase-2	103,119	Lipopolysaccharide	cyclooxygenase-2	CHEBI:16412	5743	Chemical	Gene	promoted|nsubj|START_ENTITY promoted|dobj|proliferation proliferation|nmod|cells cells|nmod|induction induction|nmod|expression expression|amod|END_ENTITY	Lipopolysaccharide promoted proliferation and invasion of endometriotic stromal cells via induction of cyclooxygenase-2 expression .
9880592	0	Lipopolysaccharide	0,18	cyclooxygenase-2	90,106	Lipopolysaccharide	cyclooxygenase-2	CHEBI:16412	29527(Tax:10116)	Chemical	Gene	injected|nsubj|START_ENTITY injected|nmod|induction induction|nmod|cells cells|amod|END_ENTITY	Lipopolysaccharide injected into the cerebral ventricle evokes fever through induction of cyclooxygenase-2 in brain endothelial cells .
8603989	0	Lipopolysaccharide	0,18	cysteine-rich_intestinal_protein	29,61	Lipopolysaccharide	cysteine-rich intestinal protein	CHEBI:16412	691657(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Lipopolysaccharide regulates cysteine-rich_intestinal_protein , a zinc-finger protein , in immune cells and plasma .
10573519	0	Lipopolysaccharide	0,18	hepatocyte_growth_factor	45,69	Lipopolysaccharide	hepatocyte growth factor	CHEBI:16412	24446(Tax:10116)	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|effect effect|nmod|END_ENTITY	Lipopolysaccharide potentiates the effect of hepatocyte_growth_factor on hepatocyte replication in rats by augmenting AP-1 activity .
11319906	0	Lipopolysaccharide	0,18	hepatocyte_growth_factor	45,69	Lipopolysaccharide	hepatocyte growth factor	CHEBI:16412	24446(Tax:10116)	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|effect effect|nmod|END_ENTITY	Lipopolysaccharide potentiates the effect of hepatocyte_growth_factor upon replication in lung , thyroid , spleen , and colon in rats in vivo .
23146644	0	Lipopolysaccharide	0,18	miR-146a	85,93	Lipopolysaccharide	miR-146a	CHEBI:16412	406938	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Lipopolysaccharide induces the migration of human dental pulp cells by up-regulating miR-146a .
19894120	0	Lipopolysaccharide	0,18	multidrug_resistance-associated_protein_1	47,88	Lipopolysaccharide	multidrug resistance-associated protein 1	CHEBI:16412	4363	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Lipopolysaccharide increases the expression of multidrug_resistance-associated_protein_1 -LRB- MRP1 -RRB- in RAW 264.7 macrophages .
15620807	0	Lipopolysaccharide	0,18	myostatin	29,38	Lipopolysaccharide	myostatin	CHEBI:16412	100379652(Tax:7998)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Lipopolysaccharide regulates myostatin and MyoD independently of an increase in plasma cortisol in channel_catfish -LRB- Ictalurus_punctatus -RRB- .
25172547	0	Lipopolysaccharide	0,18	p53	51,54	Lipopolysaccharide	p53	CHEBI:16412	22060(Tax:10090)	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|nmod|END_ENTITY	Lipopolysaccharide downregulates the expression of p53 through activation of MDM2 and enhances activation of nuclear factor-kappa B .
8275961	0	Lipopolysaccharide	0,18	proenkephalin	27,40	Lipopolysaccharide	proenkephalin	CHEBI:16412	29237(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Lipopolysaccharide induces proenkephalin gene expression in rat lymph nodes and adrenal glands .
18323674	0	Lipopolysaccharide	0,18	proopiomelanocortin	30,49	Lipopolysaccharide	proopiomelanocortin	CHEBI:16412	18976(Tax:10090)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	Lipopolysaccharide stimulates proopiomelanocortin gene expression in AtT20 corticotroph cells .
12387885	0	Lipopolysaccharide	0,18	resistin	29,37	Lipopolysaccharide	resistin	CHEBI:16412	56729	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Lipopolysaccharide increases resistin gene expression in vivo and in vitro .
23969982	0	Lipopolysaccharide	0,18	resistin	46,54	Lipopolysaccharide	resistin	CHEBI:16412	246250(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Lipopolysaccharide inhibits the expression of resistin in adipocytes .
10679110	0	Lipopolysaccharide	0,18	scavenger_receptor_A	27,47	Lipopolysaccharide	scavenger receptor A	CHEBI:16412	20288(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Lipopolysaccharide induces scavenger_receptor_A expression in mouse macrophages : a divergent response relative to human THP-1 monocyte/macrophages .
15946254	0	Lipoteichoic_acid	0,17	Akt	131,134	Lipoteichoic acid	Akt	MESH:C009900	207	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|nmod|END_ENTITY	Lipoteichoic_acid induces nuclear factor-kappaB activation and nitric_oxide synthase expression via phosphatidylinositol 3-kinase , Akt , and p38 MAPK in RAW 264.7 macrophages .
17481719	0	Lipoteichoic_acid	0,17	FcepsilonRI	32,43	Lipoteichoic acid	FcepsilonRI	MESH:C009900	2205	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|compound|END_ENTITY	Lipoteichoic_acid downregulates FcepsilonRI expression on human mast cells through Toll-like_receptor_2 .
18802114	0	Lipoteichoic_acid	0,17	HO-1	26,30	Lipoteichoic acid	HO-1	MESH:C009900	3162	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Lipoteichoic_acid induces HO-1 expression via the TLR2/MyD88/c-Src / NADPH oxidase pathway and Nrf2 in human tracheal smooth muscle cells .
11527813	0	Lipoteichoic_acid	0,17	IL-2	42,46	Lipoteichoic acid	IL-2	MESH:C009900	3558	Chemical	Gene	interleukin-2|amod|START_ENTITY interleukin-2|appos|END_ENTITY	Lipoteichoic_acid inhibits interleukin-2 -LRB- IL-2 -RRB- function by direct binding to IL-2 .
11527813	0	Lipoteichoic_acid	0,17	IL-2	78,82	Lipoteichoic acid	IL-2	MESH:C009900	3558	Chemical	Gene	interleukin-2|amod|START_ENTITY function|nsubj|interleukin-2 function|nmod|direct direct|nmod|END_ENTITY	Lipoteichoic_acid inhibits interleukin-2 -LRB- IL-2 -RRB- function by direct binding to IL-2 .
18250466	0	Lipoteichoic_acid	0,17	TNF-alpha	92,101	Lipoteichoic acid	TNF-alpha	MESH:C009900	21926(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Lipoteichoic_acid isolated from Lactobacillus_plantarum inhibits lipopolysaccharide-induced TNF-alpha production in THP-1 cells and endotoxin shock in mice .
17481719	0	Lipoteichoic_acid	0,17	Toll-like_receptor_2	83,103	Lipoteichoic acid	Toll-like receptor 2	MESH:C009900	7097	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|nmod|END_ENTITY	Lipoteichoic_acid downregulates FcepsilonRI expression on human mast cells through Toll-like_receptor_2 .
26440284	0	Lipoteichoic_acid	0,17	Toll-like_receptor_2	114,134	Lipoteichoic acid	Toll-like receptor 2	MESH:C009900	24088(Tax:10090)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|nmod|cascade cascade|compound|END_ENTITY	Lipoteichoic_acid modulates inflammatory response in macrophages after phagocytosis of titanium particles through Toll-like_receptor_2 cascade and inflammasomes .
12766200	0	Lipoteichoic_acid	0,17	VEGF	31,35	Lipoteichoic acid	VEGF	MESH:C009900	22339(Tax:10090)	Chemical	Gene	up-regulates|amod|START_ENTITY END_ENTITY|nsubj|up-regulates	Lipoteichoic_acid up-regulates VEGF expression in macrophages and pulp cells .
9617441	0	Lipoteichoic_acid	0,17	hepatocyte_growth_factor	80,104	Lipoteichoic acid	hepatocyte growth factor	MESH:C009900	3082	Chemical	Gene	stimulate|nsubj|START_ENTITY stimulate|dobj|release release|nmod|END_ENTITY	Lipoteichoic_acid and protein-A from Staphylococcus_aureus stimulate release of hepatocyte_growth_factor -LRB- HGF -RRB- by human dermal fibroblasts .
18632923	0	Lipoteichoic_acid	0,17	interleukin-6	88,101	Lipoteichoic acid	interleukin-6	MESH:C009900	3569	Chemical	Gene	synergizes|nsubj|START_ENTITY synergizes|xcomp|stimulate stimulate|dobj|secretion secretion|nmod|cells cells|amod|END_ENTITY	Lipoteichoic_acid synergizes with glycosphingolipids to potently stimulate secretion of interleukin-6 from human blood cells .
24786530	0	Lipoteichoic_acid	0,17	platelet-activating_factor_receptor	74,109	Lipoteichoic acid	platelet-activating factor receptor	MESH:C009900	5724	Chemical	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Lipoteichoic_acid from Lactobacillus_plantarum inhibits the expression of platelet-activating_factor_receptor induced by Staphylococcus_aureus lipoteichoic acid or Escherichia_coli lipopolysaccharide in human monocyte-like cells .
19440307	0	Lipoteichoic_acid	0,17	toll-like_receptor_2	79,99	Lipoteichoic acid	toll-like receptor 2	MESH:C009900	24088(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|ligands ligands|amod|END_ENTITY	Lipoteichoic_acid induces unique inflammatory responses when compared to other toll-like_receptor_2 ligands .
26261553	0	Lipoxin_A4	0,10	ABCA1	20,25	Lipoxin A4	ABCA1	MESH:C040527	19	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|compound|END_ENTITY	Lipoxin_A4 promotes ABCA1 expression and cholesterol efflux through the LXRa signaling pathway in THP-1 macrophage-derived foam cells .
10679106	0	Lipoxin_A4	0,10	IL-6	38,42	Lipoxin A4	IL-6	MESH:C040527	3569	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Lipoxin_A4 inhibits IL-1_beta-induced IL-6 , IL-8 , and matrix metalloproteinase-3 production in human synovial fibroblasts and enhances synthesis of tissue inhibitors of metalloproteinases .
19357230	0	Lipoxin_A4	0,10	IL-8	37,41	Lipoxin A4	IL-8	MESH:C040527	3576	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Lipoxin_A4 inhibits IL-1beta-induced IL-8 and ICAM-1 expression in 1321N1 human astrocytoma cells .
26261553	0	Lipoxin_A4	0,10	LXRa	72,76	Lipoxin A4	LXRa	MESH:C040527	10062	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Lipoxin_A4 promotes ABCA1 expression and cholesterol efflux through the LXRa signaling pathway in THP-1 macrophage-derived foam cells .
25702137	0	Lipoxin_A4	0,10	Nrf2	21,25	Lipoxin A4	Nrf2	MESH:C040527	4780	Chemical	Gene	Pathway|compound|START_ENTITY Pathway|compound|END_ENTITY	Lipoxin_A4 Activates Nrf2 Pathway and Ameliorates Cell Damage in Cultured Cortical Astrocytes Exposed to Oxygen-Glucose Deprivation/Reperfusion Insults .
26072084	0	Lipoxin_A4	0,10	SOCS2	118,123	Lipoxin A4	SOCS2	MESH:C040527	8835	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Lipoxin_A4 inhibits lipopolysaccharide-induced production of inflammatory cytokines in keratinocytes by up-regulating SOCS2 and down-regulating TRAF6 .
24835059	0	Lipoxin_A4	0,10	estrogen_receptor	39,56	Lipoxin A4	estrogen receptor	MESH:C040527	2099	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Lipoxin_A4 regulates expression of the estrogen_receptor and inhibits 17b-estradiol induced p38_mitogen-activated_protein_kinase phosphorylation in human endometriotic stromal cells .
3680018	0	Lipstatin	0,9	pancreatic_lipase	27,44	Lipstatin	pancreatic lipase	MESH:C054164	69060(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Lipstatin , an inhibitor of pancreatic_lipase , produced by Streptomyces toxytricini .
22170854	0	Liquiritigenin	0,14	HIF-1a	38,44	Liquiritigenin	HIF-1a	MESH:C083152	3091	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Liquiritigenin inhibits serum-induced HIF-1a and VEGF expression via the AKT/mTOR-p 70S6K signalling pathway in HeLa cells .
24888902	0	Liquiritin	0,10	ERK	21,24	Liquiritin	ERK	MESH:C512196	24338(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Liquiritin modulates ERK - and AKT/GSK __ -3 b - dependent pathways to protect against glutamate - induced cell damage in differentiated PC12 cells .
18201212	0	Liraglutide	0,11	GLP-1	32,37	Liraglutide	GLP-1	MESH:C439759	100125288	Chemical	Gene	START_ENTITY|appos|analogue analogue|compound|END_ENTITY	Liraglutide , a once-daily human GLP-1 analogue , improves pancreatic B-cell function and arginine-stimulated insulin secretion during hyperglycaemia in patients with Type_2_diabetes_mellitus .
19317822	0	Liraglutide	0,11	GLP-1	32,37	Liraglutide	GLP-1	MESH:C439759	100125288	Chemical	Gene	produces|advmod|START_ENTITY produces|nsubj|analogue analogue|compound|END_ENTITY	Liraglutide , a once-daily human GLP-1 analogue , added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with Type 2 diabetes -LRB- LEAD-1 SU -RRB- .
21584160	0	Liraglutide	0,11	GLP-1	61,66	Liraglutide	GLP-1	MESH:C439759	2641	Chemical	Gene	START_ENTITY|dep|review review|nmod|use use|nmod|analog analog|compound|END_ENTITY	Liraglutide : A review of its therapeutic use as a once daily GLP-1 analog for the management of type_2_diabetes_mellitus .
22968320	0	Liraglutide	0,11	GLP-1	27,32	Liraglutide	GLP-1	MESH:C439759	2641	Chemical	Gene	inflammation|advmod|START_ENTITY inflammation|nsubj|mimetic mimetic|compound|END_ENTITY	Liraglutide , a long-acting GLP-1 mimetic , and its metabolite attenuate inflammation after intracerebral_hemorrhage .
25140997	0	Liraglutide	19,30	GLP-1	4,9	Liraglutide	GLP-1	MESH:C439759	24952(Tax:10116)	Chemical	Gene	Cardiomyocytes|compound|START_ENTITY Analogue|dobj|Cardiomyocytes Analogue|nsubj|END_ENTITY	The GLP-1 Analogue Liraglutide Protects Cardiomyocytes from High Glucose-induced Apoptosis by Activating the Epac-1 / Akt Pathway .
17636089	0	Liraglutide	0,11	glucagon-like_peptide-1	32,55	Liraglutide	glucagon-like peptide-1	MESH:C439759	2641	Chemical	Gene	START_ENTITY|appos|analog analog|amod|END_ENTITY	Liraglutide , a once-daily human glucagon-like_peptide-1 analog , minimizes food intake in severely obese minipigs .
21205128	0	Liraglutide	0,11	glucagon-like_peptide_1	32,55	Liraglutide	glucagon-like peptide 1	MESH:C439759	2641	Chemical	Gene	START_ENTITY|appos|analogue analogue|amod|END_ENTITY	Liraglutide , a once-daily human glucagon-like_peptide_1 analogue , provides sustained improvements in glycaemic control and weight for 2 years as monotherapy compared with glimepiride in patients with type 2 diabetes .
2822304	6	Lisinopril	703,713	ACE	730,733	Lisinopril	ACE	MESH:D017706	24310(Tax:10116)	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|dobj|END_ENTITY	Lisinopril inhibited brain ACE in the subfornical organ and organum vasculosum of the lamina terminalis , circumventricular organs , where the blood brain barrier is deficient .
11433128	0	Lisinopril	171,181	angiotensin_I-converting_enzyme	25,56	Lisinopril	angiotensin I-converting enzyme	MESH:D017706	1636	Chemical	Gene	Treatment|nmod|START_ENTITY Assessment|nmod|Treatment substudy|nmod|Assessment influence|dep|substudy influence|nmod|dose dose|nmod|inhibitor inhibitor|amod|END_ENTITY	The influence of dose of angiotensin_I-converting_enzyme inhibitor on systolic blood pressure variability in heart_failure : a substudy of the Assessment of Treatment with Lisinopril and Survival in heart_failure -LRB- ATLAS -RRB- trial .
9766448	0	Lisinopril	0,10	angiotensin_I-converting_enzyme	15,46	Lisinopril	angiotensin I-converting enzyme	MESH:D017706	11421(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Lisinopril , an angiotensin_I-converting_enzyme inhibitor , prevents entry of murine hematopoietic stem cells into the cell cycle after irradiation in vivo .
12816171	0	Lisinopril	162,172	angiotensin_converting_enzyme	22,51	Lisinopril	angiotensin converting enzyme	MESH:D017706	1636	Chemical	Gene	Assessment|nmod|START_ENTITY analysis|nmod|Assessment analysis|dep|High High|nmod|therapy therapy|amod|END_ENTITY	High - versus low-dose angiotensin_converting_enzyme inhibitor therapy in the treatment of heart_failure : an economic analysis of the Assessment of Treatment with Lisinopril and Survival -LRB- ATLAS -RRB- trial .
21911117	0	Lisinopril	0,10	endothelin-1	20,32	Lisinopril	endothelin-1	MESH:D017706	24323(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Lisinopril inhibits endothelin-1 in the early period of hepatic_reperfusion_injury in a partial hepatectomy model .
15058961	0	Lithiated_hydrocarbons	0,22	RLi	100,103	Lithiated hydrocarbons	RLi	null	6059	Chemical	Gene	START_ENTITY|dep|study study|nmod|END_ENTITY	Lithiated_hydrocarbons , their conjugate bases , and corresponding radicals : a computational study of RLi -LRB- R = CH3 , CH3CH2 , CH2 = CH , and HC triple bond C -RRB- .
17456772	0	Lithium	0,7	A_beta	44,50	Lithium	A beta	MESH:D008094	351	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	Lithium reduces tau phosphorylation but not A_beta or working memory_deficits in a transgenic model with both plaques and tangles .
15572521	0	Lithium	0,7	Akt	60,63	Lithium	Akt	MESH:D008094	11651(Tax:10090)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Lithium activates the Wnt and phosphatidylinositol 3-kinase Akt signaling pathways to promote cell survival in the absence of soluble survival factors .
18544676	0	Lithium	0,7	Akt	121,124	Lithium	Akt	MESH:D008094	24185(Tax:10116)	Chemical	Gene	protection|amod|START_ENTITY protection|dep|role role|nmod|pathways pathways|dep|END_ENTITY	Lithium protection of phencyclidine-induced neurotoxicity in developing brain : the role of phosphatidylinositol-3_kinase / Akt and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signaling pathways .
10411946	0	Lithium	0,7	Akt-1	46,51	Lithium	Akt-1	MESH:D008094	207	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons .
10826666	0	Lithium	0,7	Bcl-2	48,53	Lithium	Bcl-2	MESH:D008094	596	Chemical	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|END_ENTITY	Lithium up-regulates the cytoprotective protein Bcl-2 in the CNS in vivo : a role for neurotrophic and neuroprotective effects in manic depressive_illness .
16682503	0	Lithium	0,7	Bcl-2	85,90	Lithium	Bcl-2	MESH:D008094	596	Chemical	Gene	inhibits|advmod|START_ENTITY inhibits|nsubj|methylation methylation|appos|dephosphorylation dephosphorylation|compound|END_ENTITY	Lithium inhibits ceramide - and etoposide-induced protein phosphatase_2A methylation , Bcl-2 dephosphorylation , caspase-2 activation , and apoptosis .
17697959	0	Lithium	0,7	CXCR4	41,46	Lithium	CXCR4	MESH:D008094	7852	Chemical	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|nmod|END_ENTITY	Lithium down-regulates the expression of CXCR4 in human neutrophils .
21369697	0	Lithium	0,7	EGF	53,56	Lithium	EGF	MESH:D008094	1950	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|nmod|END_ENTITY	Lithium reduces tumorigenic potential in response to EGF signaling in human colorectal_cancer cells .
17686496	0	Lithium	0,7	ERK	46,49	Lithium	ERK	MESH:D008094	24338(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Lithium regulates hippocampal neurogenesis by ERK pathway and facilitates recovery of spatial learning and memory in rats after transient global cerebral_ischemia .
17574214	0	Lithium	0,7	FoxO3a	16,22	Lithium	FoxO3a	MESH:D008094	56484(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|activity activity|amod|END_ENTITY	Lithium reduces FoxO3a transcriptional activity by decreasing its intracellular content .
23948897	0	Lithium	0,7	GSK-3b	74,80	Lithium	GSK-3b	MESH:D008094	84027(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|nmod|inhibition inhibition|nmod|END_ENTITY	Lithium attenuates scopolamine-induced memory_deficits with inhibition of GSK-3b and preservation of postsynaptic components .
22053151	6	Lithium	920,927	GSK3	931,935	Lithium	FMRP	MESH:D008094	14265(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Lithium , a GSK3 inhibitor , improved function in the Drosophila model of FXS .
18983912	5	Lithium	547,554	GSK3beta	653,661	Lithium	GSK3beta	MESH:D008094	84027(Tax:10116)	Chemical	Gene	promote|nsubj|START_ENTITY promote|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Lithium and valproate promote but wortmannin and LY294002_attenuate PACAP-induced phosphorylation of both GSK3beta and ERK1/2 , whereas MEK inhibitor PD98059 inhibits nerve growth factor - but not PACAP-induced phosphorylation of GSK3beta , suggesting that GSK3beta operates downstream of Rapt_1 but upstream of ERK1/2 in PACAP signalling .
19339873	0	Lithium	0,7	GSK3beta	34,42	Lithium	GSK3beta	MESH:D008094	56637(Tax:10090)	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	Lithium and genetic inhibition of GSK3beta enhance the effect of methamphetamine on circadian rhythms in the mouse .
14684472	0	Lithium	0,7	GluR2	79,84	Lithium	GluR2	MESH:D008094	2891	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Lithium regulates total and synaptic expression of the AMPA glutamate receptor GluR2 in vitro and in vivo .
18932008	0	Lithium	0,7	Gsk3b	16,21	Lithium	Gsk3b	MESH:D008094	84027(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|levels levels|amod|END_ENTITY	Lithium reduces Gsk3b mRNA levels : implications for Alzheimer_Disease .
24043902	0	Lithium	0,7	IFN-b	19,24	Lithium	IFN-b	MESH:D008094	15977(Tax:10090)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|production production|amod|END_ENTITY	Lithium attenuates IFN-b production and antiviral response via inhibition of TANK-binding_kinase_1 kinase activity .
12932824	0	Lithium	0,7	N-methyl-D-aspartate_receptor_subunit_2A	16,56	Lithium	N-methyl-D-aspartate receptor subunit 2A	MESH:D008094	24409(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|compound|END_ENTITY	Lithium reduced N-methyl-D-aspartate_receptor_subunit_2A tyrosine phosphorylation and its interactions with Src and Fyn mediated by PSD-95 in rat hippocampus following cerebral_ischemia .
17451429	0	Lithium	0,7	PGC-1alpha	18,28	Lithium	PGC-1alpha	MESH:D008094	338446(Tax:9913)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Lithium increases PGC-1alpha expression and mitochondrial biogenesis in primary bovine aortic endothelial cells .
11432986	0	Lithium	0,7	PKB	63,66	Lithium	PKB	MESH:D008094	207	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	Lithium inhibits caspase_3 activation and dephosphorylation of PKB and GSK3 induced by K + deprivation in cerebellar granule cells .
12932824	0	Lithium	0,7	PSD-95	132,138	Lithium	PSD-95	MESH:D008094	29495(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY mediated|nsubj|phosphorylation mediated|nmod|END_ENTITY	Lithium reduced N-methyl-D-aspartate_receptor_subunit_2A tyrosine phosphorylation and its interactions with Src and Fyn mediated by PSD-95 in rat hippocampus following cerebral_ischemia .
17189987	0	Lithium	0,7	SERCA2	29,35	Lithium	SERCA2	MESH:D008094	29693(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	Lithium suppresses epidermal SERCA2 and PMR1 levels in the rat .
25617245	0	Lithium	30,37	SLC13A5	57,64	Lithium	SLC13A5	MESH:D008094	284111	Chemical	Gene	START_ENTITY|nmod|Activity Activity|nmod|END_ENTITY	Species-specific Influence of Lithium on the Activity of SLC13A5 -LRB- NaCT -RRB- : Lithium-induced Activation is Specific for the Transporter in Primates .
25925247	0	Lithium	0,7	SnF2	32,36	Lithium	SnF2	MESH:D008094	6597	Chemical	Gene	Storage|compound|START_ENTITY Storage|nmod|END_ENTITY	Lithium Storage in Heat-Treated SnF2 / Polyacrylonitrile Anode .
26857144	0	Lithium	0,7	TGFBIp	82,88	Lithium	TGFBIp	MESH:D008094	7045	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|inhibition inhibition|nmod|expression expression|amod|END_ENTITY	Lithium inhibits tumor lymphangiogenesis and metastasis through the inhibition of TGFBIp expression in cancer cells .
21721043	0	Lithium	0,7	VEGF	18,22	Lithium	VEGF	MESH:D008094	7422	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|amod|END_ENTITY	Lithium decreases VEGF mRNA expression in leukocytes of healthy subjects and patients with bipolar_disorder .
24525248	0	Lithium	0,7	adiponectin	25,36	Lithium	adiponectin	MESH:D008094	9370	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|levels levels|compound|END_ENTITY	Lithium decreases plasma adiponectin levels in bipolar_depression .
22724081	0	Lithium	0,7	akt	146,149	Lithium	akt	MESH:D008094	207	Chemical	Gene	treatment|amod|START_ENTITY reduces|nsubj|treatment reduces|ccomp|induced induced|dobj|importance importance|nmod|activity activity|compound|END_ENTITY	Lithium treatment reduces brain_injury induced by focal ischemia with partial reperfusion and the protective mechanisms dispute the importance of akt activity .
10913502	0	Lithium	0,7	bcl-2	88,93	Lithium	bcl-2	MESH:D008094	596	Chemical	Gene	increases|nsubj|START_ENTITY increases|nmod|evidence evidence|nmod|support support|nmod|effects effects|nmod:poss|END_ENTITY	Lithium increases N-acetyl-aspartate in the human brain : in vivo evidence in support of bcl-2 's neurotrophic effects ?
16413133	0	Lithium	0,7	bcl-2	18,23	Lithium	bcl-2	MESH:D008094	396282(Tax:9031)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Lithium increases bcl-2 expression in chick cochlear nucleus and protects against deafferentation-induced cell death .
24174697	0	Lithium	82,89	bcl-2	10,15	Lithium	bcl-2	MESH:D008094	24224(Tax:10116)	Chemical	Gene	Treatment|compound|START_ENTITY Levels|nmod|Treatment Levels|amod|END_ENTITY	Increased bcl-2 Protein Levels in Rat Primary Astrocyte Culture Following Chronic Lithium Treatment .
12504924	0	Lithium	0,7	brain-derived_neurotrophic_factor	16,49	Lithium	brain-derived neurotrophic factor	MESH:D008094	12064(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Lithium induces brain-derived_neurotrophic_factor and activates TrkB in rodent cortical neurons : an essential step for neuroprotection against glutamate_excitotoxicity .
16538178	0	Lithium	0,7	brain-derived_neurotrophic_factor	50,83	Lithium	brain-derived neurotrophic factor	MESH:D008094	627	Chemical	Gene	response|amod|START_ENTITY response|nmod|gene gene|amod|END_ENTITY	Lithium response and Val66Met polymorphism of the brain-derived_neurotrophic_factor gene in Japanese patients with bipolar_disorder .
19183259	0	Lithium	0,7	brain-derived_neurotrophic_factor	177,210	Lithium	brain-derived neurotrophic factor	MESH:D008094	24225(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|secretion secretion|nmod|END_ENTITY	Lithium enhances the neuronal differentiation of neural progenitor cells in vitro and after transplantation into the avulsed ventral horn of adult rats through the secretion of brain-derived_neurotrophic_factor .
21362460	0	Lithium	0,7	brain-derived_neurotrophic_factor	25,58	Lithium	brain-derived neurotrophic factor	MESH:D008094	627	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Lithium increases plasma brain-derived_neurotrophic_factor in acute bipolar_mania : a preliminary 4-week study .
20940044	0	Lithium	0,7	c-Ret	16,21	Lithium	c-Ret	MESH:D008094	19713(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Lithium induces c-Ret expression in mouse inner medullary collecting duct cells .
8298081	0	Lithium	0,7	c-fos	42,47	Lithium	c-fos	MESH:D008094	314322(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Lithium enhances 5-HT2A receptor-mediated c-fos expression in rat cerebral cortex .
11432986	0	Lithium	0,7	caspase_3	17,26	Lithium	caspase 3	MESH:D008094	836	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	Lithium inhibits caspase_3 activation and dephosphorylation of PKB and GSK3 induced by K + deprivation in cerebellar granule cells .
1718537	0	Lithium	0,7	fos	37,40	Lithium	fos	MESH:D008094	314322(Tax:10116)	Chemical	Gene	augments|nsubj|START_ENTITY augments|dobj|expression expression|compound|END_ENTITY	Lithium augments pilocarpine-induced fos gene expression in rat brain .
2119851	0	Lithium	0,7	fos	17,20	Lithium	fos	MESH:D008094	314322(Tax:10116)	Chemical	Gene	augments|nsubj|START_ENTITY augments|dobj|expression expression|compound|END_ENTITY	Lithium augments fos protoonocogene expression in PC12 pheochromocytoma cells : implications for therapeutic action of lithium .
401098	0	Lithium	0,7	gastrin	43,50	Lithium	gastrin	MESH:D008094	2520	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|compound|END_ENTITY	Lithium inhibits basal and food-stimulated gastrin secretion .
19799873	0	Lithium	0,7	glycogen_synthase_kinase-3	28,54	Lithium	glycogen synthase kinase-3	MESH:D008094	56637(Tax:10090)	Chemical	Gene	ameliorates|amod|START_ENTITY altered|nsubj|ameliorates altered|dobj|END_ENTITY	Lithium ameliorates altered glycogen_synthase_kinase-3 and behavior in a mouse model of fragile_X_syndrome .
8994831	0	Lithium	0,7	glycogen_synthase_kinase-3	17,43	Lithium	glycogen synthase kinase-3	MESH:D008094	31248(Tax:7227)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Lithium inhibits glycogen_synthase_kinase-3 activity and mimics wingless signalling in intact cells .
16806104	0	Lithium	0,7	glycogen_synthase_kinase-3beta	18,48	Lithium	glycogen synthase kinase-3beta	MESH:D008094	2932	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	Lithium regulates glycogen_synthase_kinase-3beta in human peripheral blood mononuclear cells : implication in the treatment of bipolar_disorder .
24967390	0	Lithium	0,7	glycogen_synthase_kinase_3b	71,98	Lithium	glycogen synthase kinase 3b	MESH:D008094	2932	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|advcl|inhibiting inhibiting|dobj|activation activation|amod|END_ENTITY	Lithium enhances axonal regeneration in peripheral_nerve by inhibiting glycogen_synthase_kinase_3b activation .
24165128	0	Lithium	0,7	histone_deacetylase_1	23,44	Lithium	histone deacetylase 1	MESH:D008094	3065	Chemical	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|END_ENTITY	Lithium down-regulates histone_deacetylase_1 -LRB- HDAC1 -RRB- and induces degradation of mutant huntingtin .
8301016	0	Lithium	0,7	interleukin-2	26,39	Lithium	interleukin-2	MESH:D008094	3558	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|compound|END_ENTITY	Lithium in vitro enhances interleukin-2 production by T cells from patients with systemic_lupus_erythematosus .
17103031	0	Lithium	0,7	p21	32,35	Lithium	p21	MESH:D008094	644914	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Lithium increases expression of p21 -LRB- WAF/Cip1 -RRB- and survivin in human glioblastoma cells .
10321495	0	Lithium	0,7	p53	19,22	Lithium	p53	MESH:D008094	7157	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|levels levels|compound|END_ENTITY	Lithium attenuates p53 levels in human neuroblastoma SH-SY5Y cells .
3372682	0	Lithium	0,7	parathyroid_hormone	40,59	Lithium	parathyroid hormone	MESH:D008094	5741	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|nmod|END_ENTITY	Lithium stimulates the release of human parathyroid_hormone in vitro .
7212107	0	Lithium	0,7	parathyroid_hormone	20,39	Lithium	parathyroid hormone	MESH:D008094	5741	Chemical	Gene	effect|nsubj|START_ENTITY effect|nmod|END_ENTITY	Lithium 's effect of parathyroid_hormone .
9612848	0	Lithium	0,7	prolactin	27,36	Lithium	prolactin	MESH:D008094	24683(Tax:10116)	Chemical	Gene	enhancement|amod|START_ENTITY enhancement|nmod|response response|compound|END_ENTITY	Lithium enhancement of the prolactin response to 5-hydroxytryptophan is not reversible by inositol .
19840776	0	Lithium	0,7	tryptophan_hydroxylase_2	18,42	Lithium	tryptophan hydroxylase 2	MESH:D008094	121278	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	Lithium modulates tryptophan_hydroxylase_2 gene expression and serotonin release in primary cultures of serotonergic raphe neurons .
18974377	0	Lithium	0,7	vascular_endothelial_growth_factor	20,54	Lithium	vascular endothelial growth factor	MESH:D008094	83785(Tax:10116)	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	Lithium upregulates vascular_endothelial_growth_factor in brain endothelial cells and astrocytes .
20932949	0	Lithium_chloride	0,16	BMP-2	28,33	Lithium chloride	BMP-2	MESH:D018021	12156(Tax:10090)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|END_ENTITY	Lithium_chloride attenuates BMP-2 signaling and inhibits osteogenic differentiation through a novel WNT/GSK3 - independent mechanism .
25451297	0	Lithium_chloride	0,16	PLP	28,31	Lithium chloride	PLP	MESH:D018021	18823(Tax:10090)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	Lithium_chloride stimulates PLP and MBP expression in oligodendrocytes via Wnt/b-catenin and Akt/CREB pathways .
23904208	0	Lithium_chloride	0,16	TNFa	25,29	Lithium chloride	TNFa	MESH:D018021	21926(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Lithium_chloride induces TNFa in mouse macrophages via MEK-ERK-dependent pathway .
24312905	0	Lithium_chloride	0,16	cathepsin_H	26,37	Lithium chloride	cathepsin H	MESH:D018021	13036(Tax:10090)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Lithium_chloride enhances cathepsin_H expression and BMP-4 degradation in C3H10T1/2 cells .
11739024	0	Lithium_chloride	0,16	insulin-like_growth_factor-binding_protein-1	58,102	Lithium chloride	insulin-like growth factor-binding protein-1	MESH:D018021	25685(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Lithium_chloride inhibits the expression and secretion of insulin-like_growth_factor-binding_protein-1 .
25053111	0	Lithium_chloride	0,16	matrix_metalloproteinase-9	41,67	Lithium chloride	matrix metalloproteinase-9	MESH:D018021	17395(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Lithium_chloride suppresses LPS-mediated matrix_metalloproteinase-9 expression in macrophages through phosphorylation of GSK-3b .
10364437	0	Lithium_chloride	0,16	tyrosine_hydroxylase	43,63	Lithium chloride	tyrosine hydroxylase	MESH:D018021	7054	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Lithium_chloride induces the expression of tyrosine_hydroxylase in hNT neurons .
16346142	0	Lithocholic_Acid	50,66	M41	88,91	Lithocholic Acid	M41	MESH:D008095	100506492	Chemical	Gene	Production|nmod|START_ENTITY Production|nmod|END_ENTITY	Microbial Production of Ursodeoxycholic_Acid from Lithocholic_Acid by Fusarium equiseti M41 .
9914784	0	Lithocholic_acid	0,16	DNA_polymerase_beta	64,83	Lithocholic acid	DNA polymerase beta	MESH:D008095	5423	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Lithocholic_acid , a putative tumor promoter , inhibits mammalian DNA_polymerase_beta .
23035244	0	Lithocholic_acid	0,16	MDM4	47,51	Lithocholic acid	MDM4	MESH:D008095	4194	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Lithocholic_acid is an endogenous inhibitor of MDM4 and MDM2 .
15821044	0	Lithocholic_acid	0,16	UGT2B7	41,47	Lithocholic acid	UGT2B7	MESH:D008095	7364	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Lithocholic_acid decreases expression of UGT2B7 in Caco-2 cells : a potential role for a negative farnesoid X receptor response element .
12052824	0	Lithocholic_acid	0,16	bile_salt_export_pump	41,62	Lithocholic acid	bile salt export pump	MESH:D008095	8647	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|nmod|END_ENTITY	Lithocholic_acid decreases expression of bile_salt_export_pump through farnesoid_X_receptor antagonist activity .
26759698	0	Lobaric_Acid	0,12	VCAM-1	22,28	Lobaric Acid	VCAM-1	MESH:C104417	22329(Tax:10090)	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Lobaric_Acid Inhibits VCAM-1 Expression in TNF-a-Stimulated Vascular Smooth Muscle Cells via Modulation of NF-kB and MAPK Signaling Pathways .
15911306	0	Lobelane	0,8	vesicular_monoamine_transporter-2	44,77	Lobelane	vesicular monoamine transporter-2	MESH:C540157	6571	Chemical	Gene	analogues|nsubj|START_ENTITY analogues|nmod|ligands ligands|nmod|END_ENTITY	Lobelane analogues as novel ligands for the vesicular_monoamine_transporter-2 .
15467440	0	Lonafarnib	34,44	Akt	133,136	Lonafarnib	Akt	MESH:C115354	207	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|downregulation downregulation|nmod|END_ENTITY	The farnesyltransferase inhibitor Lonafarnib induces growth_arrest or apoptosis of human lung_cancer cells without downregulation of Akt .
3024866	0	Loperamide	0,10	ACTH	48,52	Loperamide	ACTH	MESH:D008139	5443	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|levels levels|compound|END_ENTITY	Loperamide , an opiate analogue , inhibits plasma ACTH levels in patients with Addison 's _ disease .
25872171	0	Lornoxicam	14,24	TLR2	28,32	Lornoxicam	TLR2	MESH:C059451	7097	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	The Effect of Lornoxicam on TLR2 and TLR4 Messenger RNA Expression and Tumor_Necrosis_Factor-a , Interleukin-6 , and Interleukin-8 Secretion in Patients With Systemic Complications of Acute Pancreatitis .
9793603	0	Losartan	0,8	ACE	30,33	Losartan	ACE	MESH:D019808	1636	Chemical	Gene	START_ENTITY|nmod|alternative alternative|nmod|END_ENTITY	Losartan as an alternative to ACE inhibitors in patients with renal_dysfunction .
7922595	0	Losartan	74,82	AII	109,112	Losartan	AII	MESH:D019808	24179(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|nmod|receptors receptors|compound|END_ENTITY	Tonic neuronal inhibition by AII revealed by iontophoretic application of Losartan , a specific antagonist of AII type-1 receptors .
23456824	0	Losartan	0,8	AKT	28,31	Losartan	AKT	MESH:D019808	24185(Tax:10116)	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|END_ENTITY	Losartan affects glomerular AKT and mTOR phosphorylation in an experimental model of type 1 diabetic_nephropathy .
8301562	0	Losartan	0,8	ANF	46,49	Losartan	ANF	MESH:D019808	24602(Tax:10116)	Chemical	Gene	improves|nsubj|START_ENTITY improves|nmod|END_ENTITY	Losartan improves the natriuretic response to ANF in rats with high-output heart_failure .
16601194	0	Losartan	0,8	AT1	13,16	Losartan	AT1	MESH:D019808	11607(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Losartan , an AT1 antagonist , prevents aortic_aneurysm in a mouse model of Marfan_syndrome .
9152365	0	Losartan	0,8	AT1	43,46	Losartan	AT1	MESH:D019808	185	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|receptors receptors|compound|END_ENTITY	Losartan , a selective inhibitor of subtype AT1 receptors for angiotensin_II , inhibits the binding of N-formylmethionyl-leucyl-phenylalanine to neutrophil receptors .
26168042	0	Losartan	8,16	AT1R	40,44	Losartan	AT1R	MESH:D019808	81638(Tax:10116)	Chemical	Gene	Up-Regulates|compound|START_ENTITY END_ENTITY|nsubj|Up-Regulates	Chronic Losartan Treatment Up-Regulates AT1R and Increases the Heart Vulnerability to Acute Onset of Ischemia and Reperfusion Injury in Male Rats .
18037773	0	Losartan	163,171	Angiotensin_II	137,151	Losartan	Angiotensin II	MESH:D019808	183	Chemical	Gene	Therapy|compound|START_ENTITY Therapy|compound|END_ENTITY	Design and baseline characteristics of an observational study in Japanese patients with hypertension : Japan Hypertension Evaluation with Angiotensin_II Antagonist Losartan Therapy -LRB- J-HEALTH -RRB- .
18360050	0	Losartan	205,213	Angiotensin_II	179,193	Losartan	Angiotensin II	MESH:D019808	183	Chemical	Gene	Therapy|compound|START_ENTITY Therapy|compound|END_ENTITY	Efficacy and safety of long-term losartan therapy demonstrated by a prospective observational study in Japanese patients with hypertension : The Japan Hypertension Evaluation with Angiotensin_II Antagonist Losartan Therapy -LRB- J-HEALTH -RRB- study .
18497466	0	Losartan	165,173	Angiotensin_II	139,153	Losartan	Angiotensin II	MESH:D019808	183	Chemical	Gene	Therapy|compound|START_ENTITY Therapy|compound|END_ENTITY	Impact of blood pressure control on cardiovascular events in 26,512 Japanese hypertensive patients : the Japan Hypertension Evaluation with Angiotensin_II Antagonist Losartan Therapy -LRB- J-HEALTH -RRB- study , a prospective nationwide observational study .
19015598	0	Losartan	208,216	Angiotensin_II	182,196	Losartan	Angiotensin II	MESH:D019808	183	Chemical	Gene	Therapy|compound|START_ENTITY Therapy|compound|END_ENTITY	The importance of home blood pressure measurement for preventing stroke and cardiovascular_disease in hypertensive patients : a sub-analysis of the Japan Hypertension Evaluation with Angiotensin_II Antagonist Losartan Therapy -LRB- J-HEALTH -RRB- study , a prospective nationwide observational study .
21632472	0	Losartan	208,216	Angiotensin_II	182,196	Losartan	Angiotensin II	MESH:D019808	183	Chemical	Gene	Trial|compound|START_ENTITY Trial|compound|END_ENTITY	Effect of a reduction in uric_acid on renal outcomes during losartan treatment : a post hoc analysis of the reduction of endpoints in non-insulin-dependent_diabetes_mellitus with the Angiotensin_II Antagonist Losartan Trial .
19500499	0	Losartan	1,9	CTGF	40,44	Losartan	CTGF	MESH:D019808	14219(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	-LSB- Losartan inhibits high glucose-induced CTGF expression via ERK1/2 MAPK pathways in mouse mesangial cells -RSB- .
25272939	0	Losartan	0,8	IL-1beta	36,44	Losartan	IL-1beta	MESH:D019808	16176(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|compound|END_ENTITY	Losartan inhibits LPS + ATP-induced IL-1beta secretion from mouse primary macrophages by suppressing NALP3 inflammasome .
19230890	0	Losartan	0,8	PAI-1	72,77	Losartan	PAI-1	MESH:D019808	24617(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|nmod|END_ENTITY	Losartan reduces liver expression of plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- in a high fat-induced rat nonalcoholic fatty_liver_disease model .
22217266	0	Losartan	0,8	STAT1	18,23	Losartan	STAT1	MESH:D019808	6772	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|compound|END_ENTITY	Losartan inhibits STAT1 activation and protects human glomerular mesangial cells from angiotensin_II induced premature senescence .
10432413	0	Losartan	0,8	TGF-beta1	36,45	Losartan	TGF-beta1	MESH:D019808	7040	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|levels levels|nmod|END_ENTITY	Losartan decreases plasma levels of TGF-beta1 in transplant patients with chronic_allograft_nephropathy .
19416517	0	Losartan	0,8	angiotensin-II_type_1_receptor	13,43	Losartan	angiotensin-II type 1 receptor	MESH:D019808	81638(Tax:10116)	Chemical	Gene	START_ENTITY|appos|blocker blocker|amod|END_ENTITY	Losartan , an angiotensin-II_type_1_receptor blocker , attenuates the liver_fibrosis development of non-alcoholic_steatohepatitis in the rat .
11073110	0	Losartan	0,8	angiotensin_II	61,75	Losartan	angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|receptors receptors|nmod|END_ENTITY	Losartan , a selective inhibitor of subtype AT1 receptors for angiotensin_II , inhibits neutrophil recruitment in the lung triggered by fMLP .
14749145	0	Losartan	0,8	angiotensin_II	19,33	Losartan	angiotensin II	MESH:D019808	183	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|compound|END_ENTITY	Losartan and other angiotensin_II antagonists for nephropathy in type_2_diabetes_mellitus : a review of the clinical trial evidence .
1598061	0	Losartan	0,8	angiotensin_II	21,35	Losartan	angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Losartan , a specific angiotensin_II receptor antagonist , increases angiotensin I and angiotensin_II release from isolated rat hind legs : evidence for locally regulated renin-angiotensin system in vascular tissue .
18940180	0	Losartan	0,8	angiotensin_II	44,58	Losartan	angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|nmod|receptor receptor|nmod|END_ENTITY	Losartan , an antagonist of AT1 receptor for angiotensin_II , attenuates lipopolysaccharide-induced acute_lung_injury in rat .
19545435	0	Losartan	0,8	angiotensin_II	45,59	Losartan	angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	counteracts|nsubj|START_ENTITY counteracts|dobj|over-activation over-activation|amod|hyper-reactivity hyper-reactivity|nmod|END_ENTITY	Losartan counteracts the hyper-reactivity to angiotensin_II and ROCK1 over-activation in aortas isolated from streptozotocin-injected diabetic rats .
7895060	0	Losartan	0,8	angiotensin_II	132,146	Losartan	angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|ccomp|evoked evoked|nmod|END_ENTITY	Losartan , nonpeptide angiotensin_II-type 1 -LRB- AT1 -RRB- receptor antagonist , attenuates pressor and sympathoexcitatory responses evoked by angiotensin_II and L-glutamate in rostral ventrolateral medulla .
8456103	0	Losartan	10,18	angiotensin_II	33,47	Losartan	angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|antagonist antagonist|amod|END_ENTITY	Effect of Losartan , a nonpeptide angiotensin_II receptor antagonist , on drinking behavior and renal actions of centrally administered renin .
8589285	2	Losartan	425,433	angiotensin_II	301,315	Losartan	angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	given|dobj|START_ENTITY given|advcl|examine examine|dobj|role role|nmod|END_ENTITY	To examine the role of angiotensin_II in this model , rats on a low-salt diet were given CsA , CsA and the angiotensin_II receptor Type I antagonist Losartan -LRB- 10 mg/kg per day -RRB- , CsA and hydralazine/furosemide , or vehicle .
8952583	0	Losartan	0,8	angiotensin_II	60,74	Losartan	angiotensin II	MESH:D019808	183	Chemical	Gene	blocks|nsubj|START_ENTITY blocks|nmod|END_ENTITY	Losartan blocks aldosterone and renal vascular responses to angiotensin_II in humans .
9051700	0	Losartan	0,8	angiotensin_II	43,57	Losartan	angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	influences|nsubj|START_ENTITY influences|dobj|effects effects|nmod|END_ENTITY	Losartan influences behavioural effects of angiotensin_II in rats .
9152365	0	Losartan	0,8	angiotensin_II	61,75	Losartan	angiotensin II	MESH:D019808	183	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|receptors receptors|nmod|END_ENTITY	Losartan , a selective inhibitor of subtype AT1 receptors for angiotensin_II , inhibits the binding of N-formylmethionyl-leucyl-phenylalanine to neutrophil receptors .
9238761	0	Losartan	14,22	angiotensin_II	27,41	Losartan	angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	The effect of Losartan , an angiotensin_II antagonist , on cardiac function , mass and morphology in rats after repeated hyperbaric exposures .
9425616	0	Losartan	0,8	angiotensin_II	43,57	Losartan	angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	influences|nsubj|START_ENTITY influences|dobj|effects effects|nmod|END_ENTITY	Losartan influences behavioural effects of angiotensin_II -LRB- 3-7 -RRB- in rats .
20436376	0	Losartan	125,133	angiotensin_II_type_1_receptor	86,116	Losartan	angiotensin II type 1 receptor	MESH:D019808	185	Chemical	Gene	impairs|dobj|START_ENTITY impairs|nsubj|polymorphism polymorphism|nmod|alanine_to_threonine_at_position_163 alanine_to_threonine_at_position_163|nmod|END_ENTITY	A single-nucleotide polymorphism of alanine_to_threonine_at_position_163 of the human angiotensin_II_type_1_receptor impairs Losartan affinity .
22766267	0	Losartan	0,8	angiotensin_II_type_1_receptor	13,43	Losartan	angiotensin II type 1 receptor	MESH:D019808	81638(Tax:10116)	Chemical	Gene	START_ENTITY|appos|blocker blocker|amod|END_ENTITY	Losartan , an angiotensin_II_type_1_receptor blocker , ameliorates cerebral_ischemia-reperfusion injury via PI3K/Akt-mediated eNOS phosphorylation .
9621296	0	Losartan	0,8	angiotensin_II_type_1_receptor	13,43	Losartan	angiotensin II type 1 receptor	MESH:D019808	185	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Losartan , an angiotensin_II_type_1_receptor antagonist , lowers hematocrit in posttransplant erythrocytosis .
15655136	0	Losartan	0,8	bradykinin	19,29	Losartan	bradykinin	MESH:D019808	3827	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|compound|END_ENTITY	Losartan increases bradykinin levels in hypertensive humans .
9488222	0	Losartan	0,8	endothelin-1	42,54	Losartan	endothelin-1	MESH:D019808	24323(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|nmod|END_ENTITY	Losartan reduces constrictor responses to endothelin-1 and the thromboxane_A2 analogue in aortic rings from spontaneously hypertensive rats : role of nitric_oxide .
9622146	0	Losartan	0,8	endothelin-1	66,78	Losartan	endothelin-1	MESH:D019808	24323(Tax:10116)	Chemical	Gene	tissue|amod|START_ENTITY tissue|dep|increase increase|amod|END_ENTITY	Losartan but not verapamil inhibits angiotensin_II-induced tissue endothelin-1 increase : role of blood pressure and endothelial function .
11881132	0	Losartan	0,8	erythropoietin	22,36	Losartan	erythropoietin	MESH:D019808	2056	Chemical	Gene	modulate|nsubj|START_ENTITY modulate|dobj|production production|compound|END_ENTITY	Losartan may modulate erythropoietin production .
23299501	0	Losartan	0,8	insulin	26,33	Losartan	insulin	MESH:D019808	3630	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|delivery delivery|compound|END_ENTITY	Losartan increases muscle insulin delivery and rescues insulin 's metabolic action during lipid infusion via microvascular recruitment .
9205938	0	Losartan	0,8	insulin	33,40	Losartan	insulin	MESH:D019808	3630	Chemical	Gene	improvement|amod|START_ENTITY improvement|nmod|action action|compound|END_ENTITY	Losartan mediated improvement in insulin action is mainly due to an increase in non-oxidative glucose metabolism and blood flow in insulin-resistant hypertensive patients .
12133317	0	Losartan	1,9	monocyte_chemoattractant_protein-1	103,137	Losartan	monocyte chemoattractant protein-1	MESH:D019808	24770(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Losartan in the rat model of bleomycin-induced pulmonary_fibrosis and its impact on the expression of monocyte_chemoattractant_protein-1 and basic_fibroblast_growth_factor -RSB- .
16242797	0	Losartan	0,8	monocyte_chemoattractant_protein-1	17,51	Losartan	monocyte chemoattractant protein-1	MESH:D019808	24770(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|amod|END_ENTITY	Losartan reduces monocyte_chemoattractant_protein-1 expression in aortic tissues of 2K1C hypertensive rats .
11991216	0	Losartan	0,8	plasminogen_activator_inhibitor-1	43,76	Losartan	plasminogen activator inhibitor-1	MESH:D019808	5054	Chemical	Gene	effects|compound|START_ENTITY effects|nmod|END_ENTITY	Losartan and perindopril effects on plasma plasminogen_activator_inhibitor-1 and fibrinogen in hypertensive_type_2 diabetic patients .
19230890	0	Losartan	0,8	plasminogen_activator_inhibitor-1	37,70	Losartan	plasminogen activator inhibitor-1	MESH:D019808	24617(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|nmod|PAI-1 PAI-1|amod|END_ENTITY	Losartan reduces liver expression of plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- in a high fat-induced rat nonalcoholic fatty_liver_disease model .
8456103	0	Losartan	10,18	renin	134,139	Losartan	renin	MESH:D019808	24715(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|acl|drinking drinking|dobj|actions actions|nmod|END_ENTITY	Effect of Losartan , a nonpeptide angiotensin_II receptor antagonist , on drinking behavior and renal actions of centrally administered renin .
26185373	0	Losartan	0,8	sirtuin_1	19,28	Losartan	sirtuin 1	MESH:D019808	309757(Tax:10116)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Losartan activates sirtuin_1 in rat reduced-size orthotopic liver transplantation .
1397042	0	Losartan_potassium	0,18	angiotensin_II	47,61	Losartan potassium	angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	cross|advmod|START_ENTITY cross|nsubj|antagonist antagonist|nmod|END_ENTITY	Losartan_potassium , a nonpeptide antagonist of angiotensin_II , chronically administered p.o. does not readily cross the blood-brain barrier .
25965709	0	LosmApimod	28,38	p38	50,53	LosmApimod	p38	MESH:C543534	1432	Chemical	Gene	START_ENTITY|nmod|MAP MAP|compound|END_ENTITY	Rationale and design of the LosmApimod To Inhibit p38 MAP kinase as a TherapeUtic target and moDify outcomes after an acute_coronary_syndromE trial .
24930728	0	Losmapimod	0,10	p38	20,23	Losmapimod	p38	MESH:C543534	1432	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Losmapimod , a novel p38 mitogen-activated protein kinase inhibitor , in non-ST-segment elevation myocardial_infarction : a randomised phase 2 trial .
12885571	0	Lovastatin	0,10	Abeta	20,25	Lovastatin	Abeta	MESH:D008148	11820(Tax:10090)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|compound|END_ENTITY	Lovastatin enhances Abeta production and senile_plaque_deposition in female Tg2576 mice .
16472124	0	Lovastatin	0,10	CD40	51,55	Lovastatin	CD40	MESH:D008148	958	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|compound|END_ENTITY	Lovastatin reduces apoptosis and downregulates the CD40 expression induced by TNF-alpha in cerebral vascular endothelial cells .
14630701	0	Lovastatin	0,10	E-selectin	48,58	Lovastatin	E-selectin	MESH:D008148	6401	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Lovastatin inhibits Rho-regulated expression of E-selectin by TNFalpha and attenuates_tumor cell adhesion .
12213976	0	Lovastatin	0,10	ERK	42,45	Lovastatin	ERK	MESH:D008148	24338(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|compound|END_ENTITY	Lovastatin inhibits phenylephrine-induced ERK activation and growth of cardiac .
2043425	0	Lovastatin	0,10	H-ras	79,84	Lovastatin	H-ras	MESH:D008148	3265	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|ccomp|transformed transformed|nsubj|growth growth|nmod|oncogene oncogene|compound|END_ENTITY	Lovastatin , a cholesterol biosynthesis inhibitor , inhibits the growth of human H-ras oncogene transformed cells in nude_mice .
2645482	0	Lovastatin	0,10	HMG-CoA_reductase	15,32	Lovastatin	HMG-CoA reductase	MESH:D008148	3156	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Lovastatin : an HMG-CoA_reductase inhibitor for lowering cholesterol .
20375271	0	Lovastatin	0,10	Rheb	62,66	Lovastatin	Rheb	MESH:D008148	6009	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|inhibition inhibition|nmod|END_ENTITY	Lovastatin induces VSMC differentiation through inhibition of Rheb and mTOR .
19038009	0	Lovastatin	80,90	RhoA	58,62	Lovastatin	RhoA	MESH:D008148	11848(Tax:10090)	Chemical	Gene	suppression|nmod|START_ENTITY suppression|compound|END_ENTITY	Overexpression of RhoA enhances peritoneal dissemination : RhoA suppression with Lovastatin may be useful for ovarian_cancer .
8977253	0	Lovastatin	0,10	T-cell_antigen_receptor	20,43	Lovastatin	T-cell antigen receptor	MESH:D008148	6962	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dep|signaling signaling|nsubj|END_ENTITY	Lovastatin inhibits T-cell_antigen_receptor signaling independent of its effects on ras .
14630701	0	Lovastatin	0,10	TNFalpha	62,70	Lovastatin	TNFalpha	MESH:D008148	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Lovastatin inhibits Rho-regulated expression of E-selectin by TNFalpha and attenuates_tumor cell adhesion .
3162680	0	Lovastatin	0,10	apolipoprotein_B	78,94	Lovastatin	apolipoprotein B	MESH:D008148	338	Chemical	Gene	therapy|compound|START_ENTITY therapy|dep|effects effects|nmod|kinetics kinetics|nmod|END_ENTITY	Lovastatin therapy in familial_dysbetalipoproteinemia : effects on kinetics of apolipoprotein_B .
12593849	0	Lovastatin	0,10	bone_morphogenetic_protein-2	70,98	Lovastatin	bone morphogenetic protein-2	MESH:D008148	650	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|nmod|END_ENTITY	Lovastatin stimulates human vascular smooth muscle cell expression of bone_morphogenetic_protein-2 , a potent inhibitor of low-density lipoprotein-stimulated cell growth .
17586475	0	Lovastatin	0,10	erythropoietin_receptor	22,45	Lovastatin	erythropoietin receptor	MESH:D008148	2057	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Lovastatin suppresses erythropoietin_receptor surface expression through dual inhibition of glycosylation and geranylgeranylation .
8611028	0	Lovastatin	0,10	insulin	75,82	Lovastatin	insulin	MESH:D008148	3630	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Lovastatin inhibits the stimulation of mitogen-activated protein kinase by insulin in HIRcB fibroblasts .
9848777	0	Lovastatin	0,10	p27Kip1	53,60	Lovastatin	p27Kip1	MESH:D008148	1027	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|proliferation proliferation|nmod|END_ENTITY	Lovastatin inhibits mesangial cell proliferation via p27Kip1 .
16273297	0	Lovastatin	0,10	p75_TNF_receptor	22,38	Lovastatin	p75 TNF receptor	MESH:D008148	7133	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Lovastatin stimulates p75_TNF_receptor -LRB- TNFR2 -RRB- expression in primary human endothelial cells .
9220025	0	Lovastatin	0,10	prolactin	21,30	Lovastatin	prolactin	MESH:D008148	24683(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|compound|END_ENTITY	Lovastatin decreases prolactin and growth_hormone gene expression in GH4C1 cells through a cAMP dependent mechanism .
9305416	0	Loxiglumide	40,51	CCK-A	22,27	Loxiglumide	CCK-A	null	886	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Effects of a specific CCK-A antagonist , Loxiglumide , on postprandial mood and sleepiness .
11247838	0	Loxiglumide	0,11	CCK-A_receptor	15,29	Loxiglumide	CCK-A receptor	null	886	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Loxiglumide , a CCK-A_receptor antagonist , stimulates calorie intake and hunger feelings in humans .
7846294	0	Loxiglumide	0,11	cholecystokinin	21,36	Loxiglumide	cholecystokinin	null	885	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Loxiglumide inhibits cholecystokinin stimulated somatostatin secretion and simultaneously enhances gastric_acid secretion in humans .
26854577	0	Loxoprofen_sodium	0,17	C5a	55,58	Loxoprofen sodium	C5a	null	728	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|nmod|END_ENTITY	Loxoprofen_sodium induces the production of complement C5a in human serum .
2646376	0	Lu	43,45	p80	55,58	Lu	p80	null	8161	Chemical	Gene	START_ENTITY|dep|-RSB- -RSB-|amod|END_ENTITY	Monoclonal antibodies against the CD44 -LSB- In -LRB- Lu -RRB- - related p80 -RSB- , and Pgp-1 antigens in man recognize the Hermes class of lymphocyte homing receptors .
17689529	0	Lu_35-138	0,9	dopamine_D4_receptor	122,142	Lu 35-138	dopamine D4 receptor	MESH:C527164	25432(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Lu_35-138 -LRB- -LRB- + -RRB- - -LRB- S -RRB- -3 - -LCB- 1 - -LSB- 2 - -LRB- 1-acetyl-2 ,3 - dihydro-1H-indol-3-yl -RRB- ethyl -RSB- -3,6 - dihydro-2H-pyridin-4-yl -RCB- -6 - chloro-1H-indole -RRB- , a dopamine_D4_receptor antagonist and serotonin reuptake inhibitor : characterisation of its in vitro profile and pre-clinical antipsychotic potential .
21140215	0	Lubiprostone	0,12	CFTR	79,83	Lubiprostone	CFTR	MESH:C506401	1080	Chemical	Gene	Cl|compound|START_ENTITY Cl|parataxis|signaling signaling|dobj|END_ENTITY	Lubiprostone activates Cl - secretion via cAMP signaling and increases membrane CFTR in the human colon_carcinoma cell line , T84 .
22960173	0	Lubiprostone	0,12	CFTR	23,27	Lubiprostone	CFTR	MESH:C506401	100381094(Tax:8355)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Lubiprostone activates CFTR , but not ClC-2 , via the prostaglandin receptor -LRB- EP -LRB- 4 -RRB- -RRB- .
25521039	0	Lubiprostone	50,62	Mucin	15,20	Lubiprostone	Mucin	MESH:C506401	100508689	Chemical	Gene	Stimulation|nmod|START_ENTITY Stimulation|nmod|END_ENTITY	Stimulation of Mucin , Mucus , and Viscosity during Lubiprostone in Patients with Chronic Constipation may Potentially Lead to Increase of Lubrication .
17413599	0	Lubiprostone	0,12	chloride_channel	16,32	Lubiprostone	chloride channel	MESH:C506401	1181	Chemical	Gene	START_ENTITY|dep|activator activator|amod|END_ENTITY	Lubiprostone : a chloride_channel activator .
19194838	0	Lucidone	0,8	iNOS	18,22	Lucidone	iNOS	MESH:C529637	18126(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Lucidone inhibits iNOS and COX-2 expression in LPS-induced RAW 264.7 murine macrophage cells via NF-kappaB and MAPKs signaling pathways .
15311562	0	Lumiracoxib	0,11	COX-2	39,44	Lumiracoxib	COX-2	MESH:C473384	4513	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Lumiracoxib -LRB- Prexige -RRB- : a new selective COX-2 inhibitor .
26767626	0	Lupeol	0,6	NF-kappa_B	28,38	Lupeol	NF-kappa B	MESH:C010480	18033(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Lupeol inhibits LPS-induced NF-kappa_B signaling in intestinal epithelial cells and macrophages , and attenuates acute and chronic murine_colitis .
21712449	0	Lupeol	0,6	androgen_receptor	16,33	Lupeol	androgen receptor	MESH:C010480	367	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Lupeol , a novel androgen_receptor inhibitor : implications in prostate_cancer therapy .
21519792	0	Lupulone	0,8	p53	52,55	Lupulone	p53	MESH:C008299	7157	Chemical	Gene	triggers|nsubj|START_ENTITY triggers|dobj|activation activation|nmod|END_ENTITY	Lupulone triggers p38 MAPK-controlled activation of p53 and of the TRAIL receptor apoptotic pathway in human colon_cancer-derived metastatic cells .
26609426	0	Lutein	11,17	IL-8	61,65	Lutein	IL-8	MESH:D014975	3576	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|Secretion Secretion|nmod|END_ENTITY	Effects of Lutein and Zeaxanthin on LPS-Induced Secretion of IL-8 by Uveal Melanocytes and Relevant Signal Pathways .
23748778	0	Lutein	0,6	retinoic_acid_receptor	41,63	Lutein	retinoic acid receptor	MESH:D014975	5914	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Lutein , a nonprovitamin_A , activates the retinoic_acid_receptor to induce HAS3-dependent hyaluronan synthesis in keratinocytes .
7774708	0	Lutein	0,6	transthyretin	25,38	Lutein	transthyretin	MESH:D014975	7276	Chemical	Gene	START_ENTITY|acl|associated associated|nmod|END_ENTITY	Lutein associated with a transthyretin indicates carotenoid derivation and novel multiplicity of transthyretin ligands .
19509250	0	Luteolin	0,8	E-cadherin	64,74	Luteolin	E-cadherin	MESH:D047311	999	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Luteolin inhibits invasion of prostate_cancer PC3 cells through E-cadherin .
19809165	0	Luteolin	0,8	GRP94	37,42	Luteolin	GRP94	MESH:D047311	7184	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Luteolin increases the expression of GRP94 in HeLa cells .
26272613	0	Luteolin	32,40	Hepatocyte_Nuclear_Factor_4a	84,112	Luteolin	Hepatocyte Nuclear Factor 4a	MESH:D047311	3172	Chemical	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of the Flavonoid Luteolin as a Repressor of the Transcription Factor Hepatocyte_Nuclear_Factor_4a .
23145121	0	Luteolin	0,8	Hsp90	58,63	Luteolin	Hsp90	MESH:D047311	3320	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Luteolin induces carcinoma cell apoptosis through binding Hsp90 to suppress constitutive activation of STAT3 .
22269172	0	Luteolin	0,8	IGF-II	19,25	Luteolin	IGF-II	MESH:D047311	3481	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|production production|amod|END_ENTITY	Luteolin decreases IGF-II production and downregulates insulin-like_growth_factor-I_receptor signaling in HT-29 human colon_cancer cells .
18490655	0	Luteolin	0,8	IL-6	17,21	Luteolin	IL-6	MESH:D047311	16193(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|production production|compound|END_ENTITY	Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1 .
19854181	0	Luteolin	0,8	JNK	107,110	Luteolin	JNK	MESH:D047311	5599	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|advcl|inhibiting inhibiting|dobj|activation activation|compound|END_ENTITY	Luteolin , a food-derived flavonoid , suppresses adipocyte-dependent activation of macrophages by inhibiting JNK activation .
17977562	0	Luteolin	0,8	NF-kappaB	72,81	Luteolin	NF-kappaB	MESH:D047311	18033(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|advcl|blocking blocking|dobj|pathway pathway|amod|END_ENTITY	Luteolin suppresses inflammation-associated gene expression by blocking NF-kappaB and AP-1 activation pathway in mouse alveolar macrophages .
21402146	0	Luteolin	0,8	Nrf2	18,22	Luteolin	Nrf2	MESH:D047311	4780	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Luteolin inhibits Nrf2 leading to negative regulation of the Nrf2/ARE pathway and sensitization of human lung_carcinoma A549 cells to therapeutic drugs .
24024667	0	Luteolin	0,8	Nrf2	95,99	Luteolin	Nrf2	MESH:D047311	18024(Tax:10090)	Chemical	Gene	inhibits|advcl|START_ENTITY inhibits|nmod|activation activation|nmod|END_ENTITY	Luteolin , a bioflavonoid inhibits Azoxymethane-induced colorectal_cancer through activation of Nrf2 signaling .
24747074	0	Luteolin	0,8	Nrf2	22,26	Luteolin	Nrf2	MESH:D047311	18024(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dep|signaling signaling|nsubj|END_ENTITY	Luteolin inhibits the Nrf2 signaling pathway and tumor growth in vivo .
24761924	0	Luteolin	0,8	Nrf2	123,127	Luteolin	Nrf2	MESH:D047311	18024(Tax:10090)	Chemical	Gene	sensitizes|nsubj|START_ENTITY sensitizes|dobj|lines lines|nmod|drugs drugs|nmod|inhibition inhibition|nmod|pathway pathway|amod|END_ENTITY	Luteolin sensitizes two oxaliplatin-resistant colorectal_cancer cell lines to chemotherapeutic drugs via inhibition of the Nrf2 pathway .
25815323	0	Luteolin	10,18	Oct-4	53,58	Luteolin	Oct-4	MESH:D047311	5460	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|Expression Expression|nmod|END_ENTITY	Effect of Luteolin and Apigenin on the Expression of Oct-4 , Sox2 , and c-Myc in Dental Pulp Cells with In Vitro Culture .
23593654	0	Luteolin	0,8	RSK	45,48	Luteolin	RSK	MESH:D047311	6197	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|appos|END_ENTITY	Luteolin is a novel p90 ribosomal_S6_kinase -LRB- RSK -RRB- inhibitor that suppresses Notch4 signaling by blocking the activation of Y-box_binding_protein-1 -LRB- YB-1 -RRB- .
26302339	0	Luteolin	12,20	SREBP-2	32,39	Luteolin	SREBP-2	MESH:D047311	6721	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	The Flavone Luteolin Suppresses SREBP-2 Expression and Post-Translational Activation in Hepatic Cells .
23386290	0	Luteolin	0,8	catechol-O-methyltransferase	38,66	Luteolin	catechol-O-methyltransferase	MESH:D047311	1312	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Luteolin is a rare substrate of human catechol-O-methyltransferase favoring a para-methylation .
16702314	0	Luteolin	0,8	cyclooxygenase-2	44,60	Luteolin	cyclooxygenase-2	MESH:D047311	19225(Tax:10090)	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|expression expression|amod|END_ENTITY	Luteolin and chrysin differentially inhibit cyclooxygenase-2 expression and scavenge reactive oxygen species but similarly inhibit prostaglandin-E2 formation in RAW 264.7 cells .
21705614	0	Luteolin	0,8	cyclooxygenase-2	135,151	Luteolin	cyclooxygenase-2	MESH:D047311	19225(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Luteolin , a novel natural inhibitor of tumor_progression_locus_2 serine/threonine kinase , inhibits tumor_necrosis_factor-alpha-induced cyclooxygenase-2 expression in JB6 mouse epidermis cells .
16116295	0	Luteolin	0,8	endothelin-1	18,30	Luteolin	endothelin-1	MESH:D047311	1906	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|amod|END_ENTITY	Luteolin inhibits endothelin-1 secretion in cultured endothelial cells .
22916239	0	Luteolin	0,8	microRNA-132	17,29	Luteolin	microRNA-132	MESH:D047311	100314029(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Luteolin induces microRNA-132 expression and modulates neurite outgrowth in PC12 cells .
26517526	0	Luteolin	56,64	p300	14,18	Luteolin	p300	MESH:D047311	328572(Tax:10090)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activity activity|amod|END_ENTITY	Inhibition of p300 Lysine Acetyltransferase activity by Luteolin reduces tumor growth in head_and_neck_squamous_cell_carcinoma -LRB- HNSCC -RRB- xenograft mouse model .
16651438	0	Luteolin	0,8	signal_transducer_and_activator_of_transcription_3	33,83	Luteolin	signal transducer and activator of transcription 3	MESH:D047311	6774	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Luteolin promotes degradation in signal_transducer_and_activator_of_transcription_3 in human hepatoma cells : an implication for the antitumor potential of flavonoids .
21705614	0	Luteolin	0,8	tumor_progression_locus_2	39,64	Luteolin	tumor progression locus 2	MESH:D047311	26410(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|kinase kinase|amod|END_ENTITY	Luteolin , a novel natural inhibitor of tumor_progression_locus_2 serine/threonine kinase , inhibits tumor_necrosis_factor-alpha-induced cyclooxygenase-2 expression in JB6 mouse epidermis cells .
25933972	0	Luteolin_8-C-b-fucopyranoside	0,29	IL-6	44,48	Luteolin 8-C-b-fucopyranoside	IL-6	null	3569	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|compound|END_ENTITY	Luteolin_8-C-b-fucopyranoside downregulates IL-6 expression by inhibiting MAPKs and the NF-kB signaling pathway in human monocytic cells .
26795286	0	Lutetium-177	0,12	PSMA	13,17	Lutetium-177	PSMA	null	2346	Chemical	Gene	Therapy|compound|START_ENTITY Therapy|compound|END_ENTITY	Lutetium-177 PSMA Radioligand Therapy of Metastatic Castration-Resistant Prostate Cancer : Safety and Efficacy .
26655673	0	Ly-49	16,21	IFN-y	0,5	Ly-49	IFN-y	MESH:C105661	3458	Chemical	Gene	START_ENTITY|nsubj|modulates modulates|amod|END_ENTITY	IFN-y modulates Ly-49 receptors on NK cells in IFN-y-induced pregnancy failure .
11290784	1	Ly49	70,74	mice	189,193	Ly49	Ly49	MESH:C105661	17055(Tax:10090)	Chemical	Gene	family|amod|START_ENTITY characterized|nsubjpass|family characterized|nmod|END_ENTITY	The Ly49 family of NK cell receptors and its MHC-binding characteristics have only been well characterized in C57BL/6 -LRB- B6 -RRB- mice .
17641041	9	Ly49	1191,1195	mice	1229,1233	Ly49	Ly49	MESH:C105661	17055(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	The frequency of Ly49 expression in NF-kappaB/p52 null mice is slightly increased , indicating the specific role of NF-kappaB/p50 in Ly49 gene activation .
17641041	9	Ly49	1306,1310	mice	1229,1233	Ly49	Ly49	MESH:C105661	17055(Tax:10090)	Chemical	Gene	activation|amod|START_ENTITY NF-kappaB/p50|nmod|activation role|nmod|NF-kappaB/p50 indicating|dobj|role increased|xcomp|indicating increased|nsubjpass|frequency frequency|nmod|expression expression|nmod|END_ENTITY	The frequency of Ly49 expression in NF-kappaB/p52 null mice is slightly increased , indicating the specific role of NF-kappaB/p50 in Ly49 gene activation .
26928844	8	Ly49	1369,1373	mice	1392,1396	Ly49	Ly49	MESH:C105661	17055(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|nmod|END_ENTITY	Importantly , transgenic expression of an inhibitory self-MHC-I-specific Ly49 receptor in NKCKD mice restores WT influenza susceptibility , confirming a direct role for Ly49 .
26928844	8	Ly49	1464,1468	mice	1392,1396	Ly49	Ly49	MESH:C105661	17055(Tax:10090)	Chemical	Gene	confirming|nmod|START_ENTITY restores|xcomp|confirming restores|nsubj|expression expression|nmod|receptor receptor|nmod|END_ENTITY	Importantly , transgenic expression of an inhibitory self-MHC-I-specific Ly49 receptor in NKCKD mice restores WT influenza susceptibility , confirming a direct role for Ly49 .
23550271	0	Lycium_Barbarum_Polysaccharide	10,40	vascular_endothelial_growth_factor	58,92	Lycium Barbarum Polysaccharide	vascular endothelial growth factor	MESH:C500223	100008899(Tax:9986)	Chemical	Gene	Impact|nmod|START_ENTITY Impact|nmod|END_ENTITY	Impact of Lycium_Barbarum_Polysaccharide and Danshensu on vascular_endothelial_growth_factor in the process of retinal_neovascularization of rabbit .
18439578	0	Lycopene	0,8	ICAM-1	48,54	Lycopene	ICAM-1	MESH:C015329	3383	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Lycopene inhibits TNF-alpha-induced endothelial ICAM-1 expression and monocyte-endothelial adhesion .
21484151	0	Lycopene	0,8	IL-6	18,22	Lycopene	IL-6	MESH:C015329	3569	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Lycopene inhibits IL-6 expression in cerulein-stimulated pancreatic acinar cells .
25389438	0	Lycopene	15,23	PC3	119,122	Lycopene	PC3	MESH:C015329	57332	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	The Effects of Lycopene on the Methylation of the GSTP1 Promoter and Global Methylation in Prostatic_Cancer Cell Lines PC3 and LNCaP .
22648619	0	Lycopene	0,8	TNF-a	32,37	Lycopene	TNF-a	MESH:C015329	7124	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|secretion secretion|amod|END_ENTITY	Lycopene attenuates LPS-induced TNF-a secretion in macrophages and inflammatory markers in adipocytes exposed to macrophage-conditioned media .
22356815	0	Lycopene	0,8	caspase-3	18,27	Lycopene	caspase-3	MESH:C015329	25402(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Lycopene inhibits caspase-3 activity and reduces oxidative organ damage in a rat model of thermal_injury .
25932745	0	Lycopene	0,8	endothelin-1	40,52	Lycopene	endothelin-1	MESH:C015329	1906	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Lycopene inhibits cyclic strain-induced endothelin-1 expression through the suppression of reactive oxygen species generation and induction of heme_oxygenase-1 in human umbilical vein endothelial cells .
17049831	0	Lycopene	0,8	matrix_metalloproteinase-9	18,44	Lycopene	matrix metalloproteinase-9	MESH:C015329	4318	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Lycopene inhibits matrix_metalloproteinase-9 expression and down-regulates the binding activity of nuclear_factor-kappa_B and stimulatory_protein-1 .
22155741	0	Lycorine	0,8	iNOS	45,49	Lycorine	iNOS	MESH:C015330	18126(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|up-regulation up-regulation|amod|END_ENTITY	Lycorine inhibits lipopolysaccharide-induced iNOS and COX-2 up-regulation in RAW264 .7 cells through suppressing P38 and STATs activation and increases the survival rate of mice after LPS challenge .
3537459	0	Lymphokine	0,10	MIF	12,15	Lymphokine	MIF	null	780466(Tax:9940)	Chemical	Gene	production|amod|START_ENTITY production|appos|END_ENTITY	Lymphokine -LRB- MIF -RRB- production by glomerular T-lymphocytes in experimental glomerulonephritis .
18222087	0	Lysianadioic_acid	0,17	carboxypeptidase_B	21,39	Lysianadioic acid	carboxypeptidase B	MESH:C528726	57094	Chemical	Gene	inhibitor|advcl|START_ENTITY inhibitor|nsubj|END_ENTITY	Lysianadioic_acid , a carboxypeptidase_B inhibitor from Lysiana subfalcata .
21749932	0	Lysine	0,6	ABCA1	19,24	Lysine	ABCA1	CHEBI:25094	19	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Lysine residues of ABCA1 are required for the interaction with apoA-I .
12080090	0	Lysine	0,6	Dot1	63,67	Lysine	Dot1	CHEBI:25094	852050(Tax:4932)	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|domain domain|nmod|H3 H3|nmod|END_ENTITY	Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association .
22402663	0	Lysine	0,6	FOXO3	22,27	Lysine	FOXO3	CHEBI:25094	2309	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	Lysine methylation of FOXO3 regulates oxidative stress-induced neuronal cell death .
24036101	0	Lysine	0,6	IGF-I	19,24	Lysine	IGF-I	CHEBI:25094	3479	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Lysine residues of IGF-I are substrates for transglutaminases and modulate downstream IGF-I signalling .
25564517	0	Lysine	43,49	KDM4A	62,67	Lysine	KDM4A	CHEBI:25094	9682	Chemical	Gene	Associates|compound|START_ENTITY Associates|compound|END_ENTITY	A Coding Single-Nucleotide Polymorphism in Lysine Demethylase KDM4A Associates with Increased Sensitivity to mTOR Inhibitors .
21131967	0	Lysine	0,6	RelA	40,44	Lysine	RelA	CHEBI:25094	5970	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	Lysine methylation of the NF-kB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-kB signaling .
22043315	0	Lysine	0,6	USP46	32,37	Lysine	USP46	CHEBI:25094	69727(Tax:10090)	Chemical	Gene	residue|compound|START_ENTITY residue|nmod|END_ENTITY	Lysine 92 amino_acid residue of USP46 , a gene associated with ` behavioral despair ' in mice , influences the deubiquitinating enzyme activity .
16849322	0	Lysine	0,6	beta-catenin	37,49	Lysine	beta-catenin	CHEBI:25094	1499	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Lysine residues Lys-19 and Lys-49 of beta-catenin regulate its levels and function in T cell factor transcriptional activation and neoplastic_transformation .
11923477	0	Lysine	0,6	oxytocin_receptor	52,69	Lysine	oxytocin receptor	CHEBI:25094	5021	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Lysine 270 in the third intracellular domain of the oxytocin_receptor is an important determinant for G_alpha -LRB- q -RRB- coupling specificity .
7518267	0	Lysine	0,6	phospholipase_A2	29,45	Lysine	phospholipase A2	CHEBI:25094	406141(Tax:7460)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Lysine residues in bee venom phospholipase_A2 are important for binding to human monoclonal or polyclonal antibodies of the IgG4 isotope .
24415758	0	Lysine	0,6	progesterone_receptor	22,43	Lysine	progesterone receptor	CHEBI:25094	5241	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	Lysine methylation of progesterone_receptor at activation function 1 regulates both ligand-independent activity and ligand sensitivity of the receptor .
26473723	0	Lysophosphatidic_Acid	39,60	LPA1	71,75	Lysophosphatidic Acid	LPA1	MESH:C032881	1902	Chemical	Gene	Phosphorylation|nmod|START_ENTITY Receptors|nsubj|Phosphorylation Receptors|dobj|END_ENTITY	Phosphorylation and Internalization of Lysophosphatidic_Acid Receptors LPA1 , LPA2 , and LPA3 .
24049655	0	Lysophosphatidic_Acid	0,21	MCP-1	33,38	Lysophosphatidic Acid	MCP-1	MESH:C032881	20296(Tax:10090)	Chemical	Gene	Secretion|compound|START_ENTITY Secretion|compound|END_ENTITY	Lysophosphatidic_Acid Stimulates MCP-1 Secretion from C2C12 Myoblast .
15618220	0	Lysophosphatidic_acid	0,21	AKT/PKB	157,164	Lysophosphatidic acid	AKT/PKB	MESH:C032881	207	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|activation activation|nmod|END_ENTITY	Lysophosphatidic_acid -LRB- LPA -RRB- protects primary chronic_lymphocytic_leukemia cells from apoptosis through LPA receptor activation of the anti-apoptotic protein AKT/PKB .
18779657	0	Lysophosphatidic_acid	0,21	Akt1	81,85	Lysophosphatidic acid	Akt1	MESH:C032881	207	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Lysophosphatidic_acid induces cell migration through the selective activation of Akt1 .
26854204	0	Lysophosphatidic_acid	0,21	Arf6	32,36	Lysophosphatidic acid	Arf6	MESH:C032881	382	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Lysophosphatidic_acid activates Arf6 to promote the mesenchymal_malignancy of renal_cancer .
23036978	0	Lysophosphatidic_acid	0,21	BACE1	40,45	Lysophosphatidic acid	BACE1	MESH:C032881	23621	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Lysophosphatidic_acid induces increased BACE1 expression and Ab formation .
12488350	0	Lysophosphatidic_acid	0,21	C-type_natriuretic_peptide	31,57	Lysophosphatidic acid	C-type natriuretic peptide	MESH:C032881	4880	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	Lysophosphatidic_acid inhibits C-type_natriuretic_peptide activation of guanylyl cyclase-B .
21441463	0	Lysophosphatidic_acid	0,21	CD36	50,54	Lysophosphatidic acid	CD36	MESH:C032881	12491(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Lysophosphatidic_acid suppresses endothelial cell CD36 expression and promotes angiogenesis via a PKD-1-dependent signaling pathway .
12763014	0	Lysophosphatidic_acid	0,21	CREB	33,37	Lysophosphatidic acid	CREB	MESH:C032881	81646(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|xcomp|END_ENTITY	Lysophosphatidic_acid stimulates CREB through mitogen - _ and_stress-activated_protein_kinase-1 .
9705355	0	Lysophosphatidic_acid	0,21	EDG-1	64,69	Lysophosphatidic acid	EDG-1	MESH:C032881	1901	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Lysophosphatidic_acid stimulates the G-protein-coupled receptor EDG-1 as a low affinity agonist .
12670925	0	Lysophosphatidic_acid	0,21	LPA1	106,110	Lysophosphatidic acid	LPA1	MESH:C032881	1902	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Lysophosphatidic_acid -LRB- LPA -RRB- enhances the metastatic potential of human colon_carcinoma DLD1 cells through LPA1 .
14660630	0	Lysophosphatidic_acid	0,21	LPA1	110,114	Lysophosphatidic acid	LPA1	MESH:C032881	1902	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|END_ENTITY	Lysophosphatidic_acid -LRB- LPA -RRB- in malignant_ascites stimulates motility of human pancreatic_cancer cells through LPA1 .
14744855	0	Lysophosphatidic_acid	0,21	LPA1	107,111	Lysophosphatidic acid	LPA1	MESH:C032881	1902	Chemical	Gene	stimulate|nsubj|START_ENTITY stimulate|nmod|END_ENTITY	Lysophosphatidic_acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA1 .
17692995	0	Lysophosphatidic_acid	0,21	LPA1	65,69	Lysophosphatidic acid	LPA1	MESH:C032881	14745(Tax:10090)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|END_ENTITY	Lysophosphatidic_acid stimulates astrocyte proliferation through LPA1 .
17923111	0	Lysophosphatidic_acid	0,21	LPA1	94,98	Lysophosphatidic acid	LPA1	MESH:C032881	1902	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Lysophosphatidic_acid regulates inflammation-related genes in human endothelial cells through LPA1 and LPA3 .
19491366	0	Lysophosphatidic_acid	0,21	LPA1	107,111	Lysophosphatidic acid	LPA1	MESH:C032881	281136(Tax:9913)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|receptor receptor|compound|END_ENTITY	Lysophosphatidic_acid stimulates prostaglandin_E2 production in cultured stromal endometrial cells through LPA1 receptor .
20360252	0	Lysophosphatidic_acid	0,21	LPA1	32,36	Lysophosphatidic acid	LPA1	MESH:C032881	14745(Tax:10090)	Chemical	Gene	START_ENTITY|ccomp|promote promote|nsubj|END_ENTITY	Lysophosphatidic_acid receptors LPA1 and LPA3 promote CXCL12-mediated smooth muscle progenitor cell recruitment in neointima formation .
21102517	0	Lysophosphatidic_acid	0,21	LPA1	84,88	Lysophosphatidic acid	LPA1	MESH:C032881	1902	Chemical	Gene	augments|nsubj|START_ENTITY augments|nmod|receptor receptor|amod|END_ENTITY	Lysophosphatidic_acid augments human hepatocellular_carcinoma cell invasion through LPA1 receptor and MMP-9 expression .
24249637	0	Lysophosphatidic_acid	0,21	LPA1	55,59	Lysophosphatidic acid	LPA1	MESH:C032881	14745(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|vasodilation vasodilation|acl|mediated mediated|nmod|receptors receptors|nummod|END_ENTITY	Lysophosphatidic_acid induces vasodilation mediated by LPA1 receptors , phospholipase C , and endothelial_nitric_oxide_synthase .
22465231	0	Lysophosphatidic_acid	0,21	LPA3	63,67	Lysophosphatidic acid	LPA3	MESH:C032881	23566	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Lysophosphatidic_acid induces neurite branch formation through LPA3 .
21815729	0	Lysophosphatidic_acid	0,21	MCP-1	96,101	Lysophosphatidic acid	MCP-1	MESH:C032881	24770(Tax:10116)	Chemical	Gene	protect|nsubj|START_ENTITY protect|advcl|downregulating downregulating|dobj|END_ENTITY	Lysophosphatidic_acid and lovastatin might protect kidney in renal_I / R_injury by downregulating MCP-1 in rat .
23624721	0	Lysophosphatidic_acid	0,21	OC-STAMP	59,67	Lysophosphatidic acid	OC-STAMP	MESH:C032881	128506	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|END_ENTITY	Lysophosphatidic_acid stimulates osteoclast fusion through OC-STAMP and P2X7_receptor signaling .
22885106	0	Lysophosphatidic_acid	0,21	PDGF-B	88,94	Lysophosphatidic acid	PDGF-B	MESH:C032881	24628(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|secretion secretion|nmod|END_ENTITY	Lysophosphatidic_acid increases proximal tubule cell secretion of profibrotic cytokines PDGF-B and CTGF through LPA2 - and Gaq-mediated Rho and avb6 integrin-dependent activation of TGF-b .
15007093	0	Lysophosphatidic_acid	0,21	PPARgamma	58,67	Lysophosphatidic acid	PPARgamma	MESH:C032881	25664(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|compound|END_ENTITY	Lysophosphatidic_acid induces neointima formation through PPARgamma activation .
16402387	0	Lysophosphatidic_acid	0,21	RhoA	99,103	Lysophosphatidic acid	RhoA	MESH:C032881	387	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|activation activation|nmod|END_ENTITY	Lysophosphatidic_acid stimulates PC-3_prostate_cancer cell Matrigel invasion through activation of RhoA and NF-kappaB activity .
17442046	0	Lysophosphatidic_acid	0,21	RhoA	30,34	Lysophosphatidic acid	RhoA	MESH:C032881	117273(Tax:10116)	Chemical	Gene	rescues|nsubj|START_ENTITY rescues|dobj|activation activation|compound|END_ENTITY	Lysophosphatidic_acid rescues RhoA activation and phosphoinositides levels in astrocytes exposed to ethanol .
26662305	0	Lysophosphatidic_acid	0,21	RhoA	36,40	Lysophosphatidic acid	RhoA	MESH:C032881	387	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Lysophosphatidic_acid activates the RhoA and NF-kB through Akt/IkBa signaling and promotes prostate_cancer_invasion and progression by enhancing functional invadopodia formation .
21871564	0	Lysophosphatidic_acid	0,21	ST2	40,43	Lysophosphatidic acid	ST2	MESH:C032881	17082(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Lysophosphatidic_acid increases soluble ST2 expression in mouse lung and human bronchial epithelial cells .
19647363	0	Lysophosphatidic_acid	0,21	STAT3	30,35	Lysophosphatidic acid	STAT3	MESH:C032881	6774	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Lysophosphatidic_acid induces STAT3 phosphorylation and ovarian_cancer cell motility : their inhibition by curcumin .
9398658	0	Lysophosphatidic_acid	0,21	Stat1	63,68	Lysophosphatidic acid	Stat1	MESH:C032881	6772	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Lysophosphatidic_acid inhibits epidermal-growth-factor-induced Stat1 signaling in human epidermoid_carcinoma A431 cells .
22374302	0	Lysophosphatidic_acid	0,21	TGFBIp	32,38	Lysophosphatidic acid	TGFBIp	MESH:C032881	7045	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|amod|END_ENTITY	Lysophosphatidic_acid activates TGFBIp expression in human corneal fibroblasts through a TGF-b1-dependent pathway .
22101604	0	Lysophosphatidic_acid	0,21	TRPV1	41,46	Lysophosphatidic acid	TRPV1	MESH:C032881	193034(Tax:10090)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Lysophosphatidic_acid directly activates TRPV1 through a C-terminal binding site .
9407095	0	Lysophosphatidic_acid	0,21	Tiam1	59,64	Lysophosphatidic acid	Tiam1	MESH:C032881	7074	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Lysophosphatidic_acid induces threonine phosphorylation of Tiam1 in Swiss 3T3 fibroblasts via activation of protein kinase C .
16171822	0	Lysophosphatidic_acid	0,21	VEGF	72,76	Lysophosphatidic acid	VEGF	MESH:C032881	22339(Tax:10090)	Chemical	Gene	START_ENTITY|acl|induced induced|dobj|vascular_endothelial_growth_factor vascular_endothelial_growth_factor|appos|END_ENTITY	Lysophosphatidic_acid -LRB- LPA -RRB- - induced vascular_endothelial_growth_factor -LRB- VEGF -RRB- by mesothelial cells and quantification of host-derived VEGF in malignant ascites .
18396013	0	Lysophosphatidic_acid	0,21	VEGF	54,58	Lysophosphatidic acid	VEGF	MESH:C032881	7422	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Lysophosphatidic_acid -LRB- LPA -RRB- induces the expression of VEGF leading to protection against apoptosis in B-cell derived malignancies .
23707263	0	Lysophosphatidic_acid	0,21	VEGF	44,48	Lysophosphatidic acid	VEGF	MESH:C032881	83785(Tax:10116)	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|secretion secretion|nmod|END_ENTITY	Lysophosphatidic_acid promotes secretion of VEGF by increasing expression of 150-kD Oxygen-regulated_protein -LRB- ORP150 -RRB- in mesenchymal stem cells .
26306905	0	Lysophosphatidic_acid	0,21	autotaxin	62,71	Lysophosphatidic acid	autotaxin	MESH:C032881	5168	Chemical	Gene	generation|amod|START_ENTITY generation|nmod|END_ENTITY	Lysophosphatidic_acid generation by pulmonary NKT cell ENPP-2 / autotaxin exacerbates hyperoxic lung_injury .
22782863	0	Lysophosphatidic_acid	0,21	b-catenin	98,107	Lysophosphatidic acid	b-catenin	MESH:C032881	1499	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|pathway pathway|amod|END_ENTITY	Lysophosphatidic_acid induces migration of human lung-resident mesenchymal stem cells through the b-catenin pathway .
11939794	0	Lysophosphatidic_acid	0,21	endothelial_nitric-oxide_synthase	58,91	Lysophosphatidic acid	endothelial nitric-oxide synthase	MESH:C032881	287024(Tax:9913)	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Lysophosphatidic_acid and receptor-mediated activation of endothelial_nitric-oxide_synthase .
11741820	0	Lysophosphatidic_acid	0,21	epidermal_growth_factor_receptor	38,70	Lysophosphatidic acid	epidermal growth factor receptor	MESH:C032881	1956	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	Lysophosphatidic_acid upregulates the epidermal_growth_factor_receptor in human airway smooth muscle cells .
17251460	0	Lysophosphatidic_acid	0,21	epidermal_growth_factor_receptor	87,119	Lysophosphatidic acid	epidermal growth factor receptor	MESH:C032881	1956	Chemical	Gene	START_ENTITY|acl|promoting promoting|advcl|corneal_epithelial_wound_healing corneal_epithelial_wound_healing|nmod|transactivation transactivation|nmod|END_ENTITY	Lysophosphatidic_acid promoting corneal_epithelial_wound_healing by transactivation of epidermal_growth_factor_receptor .
18309089	0	Lysophosphatidic_acid	0,21	epidermal_growth_factor_receptor	63,95	Lysophosphatidic acid	epidermal growth factor receptor	MESH:C032881	1956	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Lysophosphatidic_acid induces rapid and sustained decreases in epidermal_growth_factor_receptor binding via different signaling pathways in BEAS-2B airway epithelial cells .
21832242	0	Lysophosphatidic_acid	0,21	epidermal_growth_factor_receptor	89,121	Lysophosphatidic acid	epidermal growth factor receptor	MESH:C032881	1956	Chemical	Gene	START_ENTITY|nsubj|H H|dep|exchanger_3 exchanger_3|nmod|END_ENTITY	Lysophosphatidic_acid 5 receptor induces activation of Na -LRB- + -RRB- / H -LRB- + -RRB- _ exchanger_3 via apical epidermal_growth_factor_receptor in intestinal epithelial cells .
15662527	0	Lysophosphatidic_acid	0,21	fas_ligand	33,43	Lysophosphatidic acid	fas ligand	MESH:C032881	356	Chemical	Gene	stimulates|amod|START_ENTITY END_ENTITY|nsubj|stimulates	Lysophosphatidic_acid stimulates fas_ligand microvesicle release from ovarian_cancer cells .
18802925	0	Lysophosphatidic_acid	0,21	hypoxia-inducible_factor-1alpha	75,106	Lysophosphatidic acid	hypoxia-inducible factor-1alpha	MESH:C032881	3091	Chemical	Gene	activates|nsubj|START_ENTITY activates|nmod|END_ENTITY	Lysophosphatidic_acid activates telomerase in ovarian_cancer cells through hypoxia-inducible_factor-1alpha and the PI3K pathway .
16199434	0	Lysophosphatidic_acid	0,21	interleukin-13	31,45	Lysophosphatidic acid	interleukin-13	MESH:C032881	3596	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Lysophosphatidic_acid enhances interleukin-13 gene expression and promoter activity in T cells .
17287216	0	Lysophosphatidic_acid	0,21	interleukin-13	30,44	Lysophosphatidic acid	interleukin-13	MESH:C032881	3596	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|receptor receptor|amod|END_ENTITY	Lysophosphatidic_acid induces interleukin-13 -LRB- IL-13 -RRB- receptor alpha2 expression and inhibits IL-13 signaling in primary human bronchial epithelial cells .
21915944	0	Lysophosphatidic_acid	0,21	lysophosphatidic_acid_receptor_3	64,96	Lysophosphatidic acid	lysophosphatidic acid receptor 3	MESH:C032881	23566	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Lysophosphatidic_acid induces erythropoiesis through activating lysophosphatidic_acid_receptor_3 .
23381130	0	Lysophosphatidic_acid	0,21	lysophospholipase_D	48,67	Lysophosphatidic acid	lysophospholipase D	MESH:C032881	5168	Chemical	Gene	START_ENTITY|acl|produced produced|nmod|END_ENTITY	Lysophosphatidic_acid produced by hen egg white lysophospholipase_D induces vascular development on extraembryonic membranes .
10595650	0	Lysophosphatidic_acid	0,21	nuclear_factor_kappa_B	32,54	Lysophosphatidic acid	nuclear factor kappa B	MESH:C032881	4790	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Lysophosphatidic_acid activates nuclear_factor_kappa_B and induces proinflammatory gene expression in endothelial cells .
15451027	0	Lysophosphatidic_acid	0,21	phospholipase_D	61,76	Lysophosphatidic acid	phospholipase D	MESH:C032881	2822	Chemical	Gene	increases|amod|START_ENTITY phosphatidic_acid|nsubj|increases phosphatidic_acid|dobj|activity activity|amod|END_ENTITY	Lysophosphatidic_acid increases phosphatidic_acid formation , phospholipase_D activity and degranulation by human neutrophils .
9428812	0	Lysophosphatidic_acid	0,21	phospholipase_D	33,48	Lysophosphatidic acid	phospholipase D	MESH:C032881	2822	Chemical	Gene	stimulates|amod|START_ENTITY END_ENTITY|nsubj|stimulates	Lysophosphatidic_acid stimulates phospholipase_D activity and cell proliferation in PC-3 human prostate_cancer cells .
15482469	0	Lysophosphatidic_acid	0,21	transforming_growth_factor-beta	37,68	Lysophosphatidic acid	transforming growth factor-beta	MESH:C032881	7040	Chemical	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Lysophosphatidic_acid interacts with transforming_growth_factor-beta signaling to mediate keratinocyte growth arrest and chemotaxis .
11353786	0	Lysophosphatidic_acid	0,21	vascular_endothelial_growth_factor	35,69	Lysophosphatidic acid	vascular endothelial growth factor	MESH:C032881	7422	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|expression expression|compound|END_ENTITY	Lysophosphatidic_acid induction of vascular_endothelial_growth_factor expression in human ovarian_cancer cells .
19081821	0	Lysophosphatidic_acid	0,21	vasodilator-stimulated_phosphoprotein	36,73	Lysophosphatidic acid	vasodilator-stimulated phosphoprotein	MESH:C032881	7408	Chemical	Gene	START_ENTITY|dep|mediates mediates|amod|END_ENTITY	Lysophosphatidic_acid -LRB- LPA -RRB- - induced vasodilator-stimulated_phosphoprotein mediates lamellipodia formation to initiate motility in PC-3_prostate_cancer cells .
11882599	0	Lysophosphatidylcholine	0,23	Akt	49,52	Lysophosphatidylcholine	Akt	MESH:D008244	24185(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|compound|END_ENTITY	Lysophosphatidylcholine inhibits insulin-induced Akt activation through protein_kinase_C-alpha in vascular smooth muscle cells .
19275966	0	Lysophosphatidylcholine	0,23	C-type_natriuretic_peptide	34,60	Lysophosphatidylcholine	C-type natriuretic peptide	MESH:D008244	4880	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Lysophosphatidylcholine increases C-type_natriuretic_peptide expression in human vascular smooth muscle cells via membrane distortion .
15178707	0	Lysophosphatidylcholine	0,23	CXCR4	37,42	Lysophosphatidylcholine	CXCR4	MESH:D008244	7852	Chemical	Gene	up-regulates|amod|START_ENTITY END_ENTITY|nsubj|up-regulates	Lysophosphatidylcholine up-regulates CXCR4 chemokine_receptor expression in human CD4 T cells .
17142754	0	Lysophosphatidylcholine	0,23	IL-1beta	35,43	Lysophosphatidylcholine	IL-1beta	MESH:D008244	3553	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|compound|END_ENTITY	Lysophosphatidylcholine stimulates IL-1beta release from microglia via a P2X7_receptor-independent mechanism .
9622278	0	Lysophosphatidylcholine	0,23	IL-1beta	50,58	Lysophosphatidylcholine	IL-1beta	MESH:D008244	3553	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|nmod|END_ENTITY	Lysophosphatidylcholine induces the production of IL-1beta by human monocytes .
11795279	0	Lysophosphatidylcholine	0,23	IP-10	64,69	Lysophosphatidylcholine	IP-10	MESH:D008244	3627	Chemical	Gene	CXC|compound|START_ENTITY chemokines|nsubj|CXC chemokines|dobj|END_ENTITY	Lysophosphatidylcholine inhibits T cell-specific CXC chemokines IP-10 , MIG , and I-TAC expression induced by IFN-gamma in human endothelial cells .
15621055	0	Lysophosphatidylcholine	0,23	IP-10	80,85	Lysophosphatidylcholine	IP-10	MESH:D008244	3627	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Lysophosphatidylcholine posttranscriptionally inhibits interferon-gamma-induced IP-10 , Mig and I-Tac expression in endothelial cells .
8622597	0	Lysophosphatidylcholine	0,23	MCP-1	68,73	Lysophosphatidylcholine	MCP-1	MESH:D008244	6347	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|nmod|END_ENTITY	Lysophosphatidylcholine stimulates the expression and production of MCP-1 by human vascular endothelial cells .
11575438	0	Lysophosphatidylcholine	0,23	NF-kappaB	55,64	Lysophosphatidylcholine	NF-kappaB	MESH:D008244	18033(Tax:10090)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Lysophosphatidylcholine activates transcription factor NF-kappaB and AP-1 in AR42J cells .
9518534	0	Lysophosphatidylcholine	0,23	apolipoprotein_B	34,50	Lysophosphatidylcholine	apolipoprotein B	MESH:D008244	338	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|secretion secretion|amod|END_ENTITY	Lysophosphatidylcholine increases apolipoprotein_B secretion by enhancing lipid synthesis and decreasing its intracellular degradation in HepG2 cells .
9130444	0	Lysophosphatidylcholine	0,23	heparin-binding_epidermal_growth_factor-like_growth_factor	48,106	Lysophosphatidylcholine	heparin-binding epidermal growth factor-like growth factor	MESH:D008244	1839	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Lysophosphatidylcholine increases expression of heparin-binding_epidermal_growth_factor-like_growth_factor in human T lymphocytes .
9734473	0	Lysophosphatidylcholine	0,23	interferon_gamma	50,66	Lysophosphatidylcholine	interferon gamma	MESH:D008244	3458	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	Lysophosphatidylcholine enhances cytokine-induced interferon_gamma expression in human T lymphocytes .
8828503	0	Lysophosphatidylcholine	0,23	interleukin-6	35,48	Lysophosphatidylcholine	interleukin-6	MESH:D008244	24498(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|amod|END_ENTITY	Lysophosphatidylcholine stimulates interleukin-6 release from rat anterior pituitary cells in vitro .
11223425	0	Lysophosphatidylcholine	0,23	matrix_metalloproteinase_2	51,77	Lysophosphatidylcholine	matrix metalloproteinase 2	MESH:D008244	282872(Tax:9913)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|secretion secretion|nmod|END_ENTITY	Lysophosphatidylcholine increases the secretion of matrix_metalloproteinase_2 through the activation of NADH/NADPH oxidase in cultured aortic endothelial cells .
12377739	0	Lysophosphatidylcholine	0,23	monocyte_chemoattractant_protein-1	35,69	Lysophosphatidylcholine	monocyte chemoattractant protein-1	MESH:D008244	24770(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Lysophosphatidylcholine stimulates monocyte_chemoattractant_protein-1 gene expression in rat aortic smooth muscle cells .
11872373	0	Lysophosphatidylcholine	0,23	prostacyclin_stimulating_factor	51,82	Lysophosphatidylcholine	prostacyclin stimulating factor	MESH:D008244	3490	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Lysophosphatidylcholine inhibits the expression of prostacyclin_stimulating_factor in cultured vascular smooth muscle cells .
11882599	0	Lysophosphatidylcholine	0,23	protein_kinase_C-alpha	72,94	Lysophosphatidylcholine	protein kinase C-alpha	MESH:D008244	24680(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Lysophosphatidylcholine inhibits insulin-induced Akt activation through protein_kinase_C-alpha in vascular smooth muscle cells .
15721275	0	Lysophosphatidylcholine	0,23	tPA	32,35	Lysophosphatidylcholine	tPA	MESH:D008244	5327	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Lysophosphatidylcholine induces tPA gene expression through CRE-dependent mechanism .
20051382	0	Lysophosphatidylinositol	0,24	GPR55	160,165	Lysophosphatidylinositol	GPR55	MESH:C025449	9290	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|cells cells|acl|expressing expressing|dobj|cells cells|compound|END_ENTITY	Lysophosphatidylinositol induces rapid phosphorylation of p38 mitogen-activated protein kinase and activating_transcription_factor_2 in HEK293 cells expressing GPR55 and IM-9 lymphoblastoid cells .
21904624	0	Lysophosphatidylinositol	0,24	GPR55	55,60	Lysophosphatidylinositol	GPR55	MESH:C025449	501177(Tax:10116)	Chemical	Gene	causes|nsubj|START_ENTITY causes|dobj|retraction retraction|nmod|END_ENTITY	Lysophosphatidylinositol causes neurite retraction via GPR55 , G13 and RhoA in PC12 cells .
17673218	0	Lysyl	0,5	LOX	15,18	Lysyl	LOX	CHEBI:32568	4015	Chemical	Gene	oxidase|amod|START_ENTITY oxidase|appos|END_ENTITY	Lysyl oxidase -LRB- LOX -RRB- down-regulation by TNFalpha : a new mechanism underlying TNFalpha-induced endothelial_dysfunction .
6450752	0	Lysyl	0,5	myosin	26,32	Lysyl	myosin	CHEBI:32568	396902(Tax:9823)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Lysyl residues of cardiac myosin accessible to labeling with a fluorescent reagent , N-methyl-2-anilino-6-naphthalenesulfonyl_chloride .
15286094	0	M100240	20,27	angiotensin-converting_enzyme	52,81	M100240	angiotensin-converting enzyme	MESH:C085683	1636	Chemical	Gene	Pharmacokinetics|nmod|START_ENTITY Pharmacokinetics|appos|inhibitor inhibitor|amod|END_ENTITY	Pharmacokinetics of M100240 and MDL 100,173 , a dual angiotensin-converting_enzyme / neutral_endopeptidase inhibitor , in healthy young and elderly volunteers .
12751274	0	M100240	140,147	neutral_endopeptidase	107,128	M100240	neutral endopeptidase	MESH:C085683	4311	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Pharmacoscintigraphic assessment of the regional drug absorption of the dual angiotensin-converting_enzyme / neutral_endopeptidase inhibitor , M100240 , in healthy volunteers .
15286094	0	M100240	20,27	neutral_endopeptidase	82,103	M100240	neutral endopeptidase	MESH:C085683	4311	Chemical	Gene	Pharmacokinetics|nmod|START_ENTITY Pharmacokinetics|appos|inhibitor inhibitor|compound|END_ENTITY	Pharmacokinetics of M100240 and MDL 100,173 , a dual angiotensin-converting_enzyme / neutral_endopeptidase inhibitor , in healthy young and elderly volunteers .
15545308	0	M100240	116,123	neutral_endopeptidase	83,104	M100240	neutral endopeptidase	MESH:C085683	4311	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	The effect of food on the pharmacokinetics of a dual angiotensin-converting_enzyme / neutral_endopeptidase inhibitor , M100240 .
15127084	0	M100907	42,49	5-HT2A	14,20	M100907	5-HT2A	MESH:C079049	29595(Tax:10116)	Chemical	Gene	START_ENTITY|amod|serotonin serotonin|dep|receptors receptors|nummod|END_ENTITY	The serotonin 5-HT2A receptors antagonist M100907 prevents impairment in attentional performance by NMDA receptor blockade in the rat prefrontal cortex .
9824229	0	M100907	47,54	5-HT2a	28,34	M100907	5-HT2a	MESH:C079049	29595(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Determination of a specific 5-HT2a antagonist -LRB- M100907 -RRB- in rat and dog plasma at the femtomole/milliliter level by gas chromatography-mass spectrometry .
11334850	0	M100907	0,7	Fos	84,87	M100907	Fos	MESH:C079049	314322(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|compound|END_ENTITY	M100907 , a selective 5-HT -LRB- 2A -RRB- receptor antagonist , attenuates phencyclidine-induced Fos expression in discrete regions of rat brain .
15220383	0	M40401	54,60	lectin-like_oxidized_low-density_lipoprotein_receptor-1	120,175	M40401	lectin-like oxidized low-density lipoprotein receptor-1	MESH:C426066	140914(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|role role|nmod|END_ENTITY	The protective effect of superoxide dismutase mimetic M40401 on balloon injury-related neointima formation : role of the lectin-like_oxidized_low-density_lipoprotein_receptor-1 .
15937404	0	M475271	30,37	Src	8,11	M475271	Src	MESH:C503850	6714	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	A novel Src kinase inhibitor , M475271 , inhibits VEGF-induced human umbilical vein endothelial cell proliferation and migration .
16974068	0	M475271	31,38	vascular_endothelial-cadherin	61,90	M475271	vascular endothelial-cadherin	MESH:C503850	1003	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	The novel Src kinase inhibitor M475271 inhibits VEGF-induced vascular_endothelial-cadherin and beta-catenin phosphorylation but increases their association .
17588563	0	M62812	52,58	Toll-like_receptor_4	0,20	M62812	Toll-like receptor 4	MESH:C525083	21898(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Toll-like_receptor_4 signal transduction inhibitor , M62812 , suppresses endothelial cell and leukocyte activation and prevents lethal septic_shock in mice .
23833955	0	M8046	11,16	COX-2	34,39	M8046	COX-2	null	26198(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of M8046 on expression of COX-2 / PGE2 in spinal cord and DRG in rats with neuropathic_pain -RSB- .
25049354	2	M8I	522,525	MMP-8	505,510	M8I	TNF-a	null	21926(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	In this article , we report that MMP-8 is upregulated in LPS-stimulated BV2 microglial cells and primary cultured microglia , and treatment of MMP-8 inhibitor -LRB- M8I -RRB- or MMP-8 short hairpin RNA suppresses proinflammatory molecules , particularly TNF-a secretion .
22169113	0	MBX-8025	31,39	PPAR	15,19	MBX-8025	PPAR	MESH:C572244	5465	Chemical	Gene	Effects|dep|START_ENTITY Effects|nmod|END_ENTITY	Effects of the PPAR - agonist MBX-8025 on atherogenic_dyslipidemia .
25857706	0	MBX_2168	58,66	TAOK3	0,5	MBX 2168	TAOK3	null	51347	Chemical	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	TAOK3 phosphorylates the methylenecyclopropane nucleoside MBX_2168 to its monophosphate .
16121987	0	MC-1	8,12	tissue_plasminogen_activator	43,71	MC-1	tissue plasminogen activator	null	25692(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of MC-1 alone and in combination with tissue_plasminogen_activator in focal ischemic_brain_injury in rats .
26041281	0	MC132	17,22	p65	94,97	MC132	p65	null	5970	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	Poxvirus protein MC132 from Molluscum_Contagiosum_Virus inhibits NFkB activation by targeting p65 for degradation .
11493620	0	MC148	0,5	CCR8	96,100	MC148	CCR8	null	12776(Tax:10090)	Chemical	Gene	antagonist|nsubj|START_ENTITY antagonist|nmod|END_ENTITY	MC148 encoded by human molluscum contagiosum poxvirus is an antagonist for human but not murine CCR8 .
1724761	0	MC903	0,5	nerve_growth_factor	75,94	MC903	nerve growth factor	MESH:C055085	4803	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|synthesis synthesis|nmod|END_ENTITY	MC903 , an analogue of 1,25-dihydroxyvitamin _ D3 , increases the synthesis of nerve_growth_factor .
2230347	0	MCA	0,3	CEA	53,56	MCA	CEA	CHEBI:34342	1084	Chemical	Gene	START_ENTITY|dep|correlation correlation|nmod|END_ENTITY	MCA in patients with breast_cancer : correlation with CEA and CA15-3 .
12708747	0	MCI-154	159,166	myosin	28,34	MCI-154	myosin	MESH:C052228	79784	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|dep|effects	Mg-ATPase and Ca + activated myosin AtPase activity in ventricular myofibrils from non-failing and diseased human hearts -- effects of calcium sensitizing agents MCI-154 , DPI 201-106 , and caffeine .
15868956	0	MCI-186	0,7	EGFR	53,57	MCI-186	EGFR	MESH:C005435	1956	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|suppression suppression|nmod|phosphorylation phosphorylation|amod|END_ENTITY	MCI-186 inhibits tumor growth through suppression of EGFR phosphorylation and cell cycle arrest .
10887938	0	MCI-225	47,54	5-HT3_receptor	110,124	MCI-225	5-HT3 receptor	MESH:C085298	79246(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|inhibitor inhibitor|nmod|END_ENTITY	Effects of acute and chronic administration of MCI-225 , a new selective noradrenaline reuptake inhibitor with 5-HT3_receptor blocking action , on extracellular noradrenaline levels in the hypothalamus of stressed rats .
11526964	0	MCI-225	30,37	5-HT3_receptor	78,92	MCI-225	5-HT3 receptor	MESH:C085298	79246(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|inhibitor inhibitor|nmod|antagonism antagonism|amod|END_ENTITY	The anxiolytic-like effect of MCI-225 , a selective NA reuptake inhibitor with 5-HT3_receptor antagonism .
2877508	0	MCI-9038	41,49	thrombin	22,30	MCI-9038	thrombin	MESH:C031942	100009146(Tax:9986)	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|Effect Effect|nmod|END_ENTITY	Effect of a selective thrombin inhibitor MCI-9038 on fibrinolysis in vitro and in vivo .
3603410	0	MCI-9038	41,49	thrombin	22,30	MCI-9038	thrombin	MESH:C031942	100009146(Tax:9986)	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|Effect Effect|nmod|END_ENTITY	Effect of a synthetic thrombin inhibitor MCI-9038 on experimental models of disseminated_intravascular_coagulation in rabbits .
15740781	0	MCL0129	94,101	melanocortin_4_receptor	58,81	MCL0129	melanocortin 4 receptor	MESH:C471542	4160	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Anxiolytic-like effect of a selective and non-peptidergic melanocortin_4_receptor antagonist , MCL0129 , in a social interaction test .
23413982	0	MCM-41	20,26	CO2	31,34	MCM-41	CO2	MESH:C509968	717	Chemical	Gene	START_ENTITY|nmod|capture capture|compound|END_ENTITY	Novel pore-expanded MCM-41 for CO2 capture : synthesis and characterization .
26608704	0	MCT	51,54	GABA-Transaminase	30,47	MCT	GABA-Transaminase	null	81632(Tax:10116)	Chemical	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	A study on the involvement of GABA-Transaminase in MCT induced pulmonary_hypertension .
2264021	0	MD805	41,46	thrombin	71,79	MD805	thrombin	MESH:C031942	2147	Chemical	Gene	START_ENTITY|nmod|reaction reaction|nmod|END_ENTITY	Effect of a synthetic thrombin-inhibitor MD805 on the reaction between thrombin and plasma antithrombin-III .
1682951	0	MDL72222	0,8	5-HT3_receptor	22,36	MDL72222	5-HT3 receptor	MESH:C042253	79246(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	MDL72222 , a serotonin 5-HT3_receptor antagonist , blocks MDMA 's ability to establish a conditioned place preference .
9488505	0	MDL72974	31,39	MAO-B	14,19	MDL72974	MAO-B	MESH:C058000	109731(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Effect of the MAO-B inhibitor , MDL72974 , on superoxide dismutase activity and lipid peroxidation levels in the mouse brain .
3084895	0	MDL_72145	100,109	MAO-B	136,141	MDL 72145	MAO-B	MESH:C040051	109731(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Prevention of 1-methyl-4-phenyl-1 ,2,3,6 - tetrahydropyridine-induced dopaminergic toxicity in mice by MDL_72145 , a selective inhibitor of MAO-B .
11823886	0	MDL_72222	26,35	5-HT3_receptor	0,14	MDL 72222	5-HT3 receptor	MESH:C042253	79246(Tax:10116)	Chemical	Gene	attenuates|nummod|START_ENTITY antagonist|dep|attenuates antagonist|amod|END_ENTITY	5-HT3_receptor antagonist MDL_72222 attenuates cocaine - and mazindol - , but not methylphenidate-induced neurochemical and behavioral effects in the rat .
1878073	0	MDL_72222	0,9	5-HT3_receptor	23,37	MDL 72222	5-HT3 receptor	MESH:C042253	79246(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	MDL_72222 , a selective 5-HT3_receptor antagonist , suppresses voluntary_ethanol_consumption in alcohol-preferring rats .
2059426	0	MDL_72222	0,9	5-HT3_receptor	23,37	MDL 72222	5-HT3 receptor	MESH:C042253	100009570(Tax:9986)	Chemical	Gene	START_ENTITY|dep|antagonist antagonist|amod|END_ENTITY	MDL_72222 -LRB- a selective 5-HT3_receptor antagonist -RRB- prevents stimulation of intrapulmonary C fibres by pulmonary embolization in anaesthetized rabbits .
8737967	0	MDL_72222	26,35	5-HT3_receptor	0,14	MDL 72222	5-HT3 receptor	MESH:C042253	79246(Tax:10116)	Chemical	Gene	dose-dependently|compound|START_ENTITY dose-dependently|amod|END_ENTITY	5-HT3_receptor antagonist MDL_72222 dose-dependently attenuates cocaine - and amphetamine-induced elevations of extracellular dopamine in the nucleus accumbens and the dorsal striatum .
9838105	0	MDL_72222	31,40	5-HT3_receptor	4,18	MDL 72222	5-HT3 receptor	MESH:C042253	79246(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	The 5-HT3_receptor antagonist , MDL_72222 , dose-dependently potentiates morphine-induced immediate-early gene expression in the rat caudate putamen .
7931254	0	MDL_72392	77,86	MAO-A	60,65	MDL 72392	MAO-A	MESH:C079104	29253(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY END_ENTITY|dobj|inhibitor	The acute effect of the bioprecursor of the selective brain MAO-A inhibitor , MDL_72392 , on rat pineal melatonin biosynthesis .
3780861	0	MDL_72394	75,84	monoamine_oxidase	115,132	MDL 72394	monoamine oxidase	null	29253(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Monoamine receptor sensitivity changes following chronic administration of MDL_72394 , a site-directed inhibitor of monoamine_oxidase .
2226625	0	MDL_72832	73,82	5-HT1A_receptor	96,111	MDL 72832	5-HT1A receptor	MESH:C056635	15550(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Stereospecific inhibition of non-opioid defeat analgesia in male mice by MDL_72832 , a selective 5-HT1A_receptor agonist .
23354536	0	MDMA	32,36	5HT1a	40,45	MDMA	5HT1a	MESH:D018817	3350	Chemical	Gene	START_ENTITY|nmod|function function|amod|END_ENTITY	Effects of repeated exposure to MDMA on 5HT1a autoreceptor function : behavioral and neurochemical responses to 8-OHDPAT .
19421742	9	MDMA	1561,1565	DAT	1544,1547	MDMA	DAT	MESH:D018817	574143(Tax:9544)	Chemical	Gene	occupancy|nmod|START_ENTITY occupancy|compound|END_ENTITY	The percent DAT occupancy of MDMA at a dose that suppressed operant behavior also was marginal and reflected low in vivo potency for DAT binding .
17689526	0	MDMA	0,4	IFN-gamma	39,48	MDMA	IFN-gamma	MESH:D018817	15978(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|response response|amod|END_ENTITY	MDMA -LRB- `` Ecstasy '' -RRB- suppresses the innate IFN-gamma response in vivo : a critical role for the anti-inflammatory cytokine IL-10 .
17689526	0	MDMA	0,4	IL-10	118,123	MDMA	IL-10	MESH:D018817	16153(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|parataxis|role role|nmod|END_ENTITY	MDMA -LRB- `` Ecstasy '' -RRB- suppresses the innate IFN-gamma response in vivo : a critical role for the anti-inflammatory cytokine IL-10 .
11672589	0	MDMA	31,35	IgG2a	76,81	MDMA	IgG2a	MESH:D018817	367586(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	Methylenedioxymethamphetamine -LRB- MDMA ; ` Ecstasy ' -RRB- suppresses antigen specific IgG2a and IFN-gamma production .
16552717	0	MDMA	29,33	P-glycoprotein	53,67	MDMA	P-glycoprotein	MESH:D018817	5243	Chemical	Gene	transport|nmod|START_ENTITY mediated|nsubjpass|transport mediated|nmod|END_ENTITY	Apparent active transport of MDMA is not mediated by P-glycoprotein : a comparison with MDCK and Caco-2 monolayers .
22038537	0	MDMA	0,4	Per2	19,23	MDMA	Per2	MESH:D018817	63840(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	MDMA induces Per1 , Per2 and c-fos gene expression in rat suprachiasmatic nuclei .
10814832	0	MDMA	70,74	c-fos	52,57	MDMA	c-fos	MESH:D018817	314322(Tax:10116)	Chemical	Gene	response|acl|START_ENTITY response|amod|END_ENTITY	Prior experience of morphine application alters the c-fos response to MDMA -LRB- ` ecstasy ' -RRB- and cocaine in the rat striatum .
22114930	0	MDMA	51,55	interleukin-1b	10,24	MDMA	interleukin-1b	MESH:D018817	24494(Tax:10116)	Chemical	Gene	levels|nmod|START_ENTITY levels|amod|END_ENTITY	Increased interleukin-1b levels following low dose MDMA induces tolerance against the 5-HT neurotoxicity produced by challenge MDMA .
24882155	0	MDMA	41,45	oxytocin	7,15	MDMA	oxytocin	MESH:D018817	5020	Chemical	Gene	concentrations|nmod|START_ENTITY END_ENTITY|dobj|concentrations	Plasma oxytocin concentrations following MDMA or intranasal oxytocin in humans .
10936509	7	MDP	1334,1337	CD69	1353,1357	MDP	CD19	CHEBI:59414	930	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|compound|END_ENTITY	LPS induced the expression of the early activation marker CD69 by a CD14-dependent but CD18-independent mechanism , whereas MDP did not induce CD69 expression .
24700593	0	MDP	29,32	NOD2	94,98	MDP	NOD2	CHEBI:59414	777696(Tax:7955)	Chemical	Gene	interaction|compound|START_ENTITY interaction|nmod|END_ENTITY	Structural insights into the MDP binding and CARD-CARD interaction in zebrafish -LRB- Danio_rerio -RRB- NOD2 : a molecular dynamics approach .
23842682	0	MDV3100	84,91	androgen_receptor	21,38	MDV3100	androgen receptor	MESH:C540278	367	Chemical	Gene	confers|nmod|START_ENTITY confers|nsubj|mutation mutation|nmod|END_ENTITY	An F876L mutation in androgen_receptor confers genetic and phenotypic resistance to MDV3100 -LRB- enzalutamide -RRB- .
3747265	1	MD_780236	132,141	monoamine_oxidase-B	101,120	MD 780236	monoamine oxidase-B	MESH:C037871	25750(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	I. Inhibition by a selective monoamine_oxidase-B inhibitor , MD_780236 .
6132973	0	MD_780236	91,100	monoamine_oxidase-B	40,59	MD 780236	monoamine oxidase-B	MESH:C037871	4129	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Different stereoselective inhibition of monoamine_oxidase-B by the R - and S-enantiomers of MD_780236 .
6133934	0	MD_780236	33,42	monoamine_oxidase-B	2,21	MD 780236	monoamine oxidase-B	MESH:C037871	25750(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	A monoamine_oxidase-B inhibitor , MD_780236 , metabolized essentially by the A form of the enzyme in the rat .
7768273	0	ME3221	27,33	angiotensin_II	43,57	ME3221	angiotensin II	MESH:C093897	24179(Tax:10116)	Chemical	Gene	START_ENTITY|appos|receptor receptor|compound|END_ENTITY	Pharmacological profile of ME3221 , a novel angiotensin_II receptor antagonist .
23172311	0	MEHD7945A	37,46	EGFR	18,22	MEHD7945A	EGFR	null	1956	Chemical	Gene	Dual|nmod|START_ENTITY Dual|nmod|END_ENTITY	Dual targeting of EGFR and HER3 with MEHD7945A overcomes acquired resistance to EGFR inhibitors and radiation .
26036283	7	MEHP	1034,1038	THP-1	1002,1007	MEHP	THP-1	MESH:C016599	2736	Chemical	Gene	cells|nmod|START_ENTITY cells|compound|END_ENTITY	RESULTS : Treatment of PM and THP-1 cells with 180 micromolar MEHP for 24 h significantly increased PGE2 release .
15621529	0	MEI-S332	65,73	POLO_kinase	0,11	MEI-S332	POLO kinase	null	40232(Tax:7227)	Chemical	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	POLO_kinase regulates the Drosophila centromere cohesion protein MEI-S332 .
25937299	0	MEK162	53,59	MEK	38,41	MEK162	MEK	MESH:C581313	5609	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Enhancing therapeutic efficacy of the MEK inhibitor , MEK162 , by blocking autophagy or inhibiting PI3K/Akt signaling in human lung_cancer cells .
23414587	0	MEK162	0,6	NRAS	54,58	MEK162	BRAF	MESH:C581313	673	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	MEK162 for patients with advanced_melanoma harbouring NRAS or Val600 BRAF mutations : a non-randomised , open-label phase 2 study .
25804768	0	MEKi-1	22,28	MEK1/2	4,10	MEKi-1	MEK1/2	null	5604;5605	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	The MEK1/2 inhibitor , MEKi-1 , induces cell death in chronic_lymphocytic_leukemia cells under conditions that mimic the tumor microenvironment and is synergistic with fludarabine .
16324696	0	MEN16132	0,8	B2_receptor	86,97	MEN16132	B2 receptor	MESH:C506838	624	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|nmod|END_ENTITY	MEN16132 , a novel potent and selective nonpeptide antagonist for the human bradykinin B2_receptor .
10422769	0	MEN_11467	10,19	NK1	38,41	MEN 11467	NK1	MESH:C121095	6869	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Effect of MEN_11467 , a new tachykinin NK1 receptor antagonist , in acute_rectocolitis induced by acetic_acid in guinea-pigs .
10812052	0	MET-88	22,28	gamma-butyrobetaine_hydroxylase	32,63	MET-88	gamma-butyrobetaine hydroxylase	MESH:C050147	64564(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|inhibitor inhibitor|amod|END_ENTITY	Beneficial effects of MET-88 , a gamma-butyrobetaine_hydroxylase inhibitor in rats with heart_failure following myocardial_infarction .
10864034	0	MET-88	11,17	gamma-butyrobetaine_hydroxylase	21,52	MET-88	gamma-butyrobetaine hydroxylase	MESH:C050147	64564(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effects of MET-88 , a gamma-butyrobetaine_hydroxylase inhibitor , on tissue carnitine and lipid levels in rats .
11093075	0	MET-88	28,34	gamma-butyrobetaine_hydroxylase	38,69	MET-88	gamma-butyrobetaine hydroxylase	MESH:C050147	64564(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Cardioprotective effects of MET-88 , a gamma-butyrobetaine_hydroxylase inhibitor , on cardiac_dysfunction induced by ischemia/reperfusion in isolated rat hearts .
11858482	0	MElagatran	217,227	THRombin	232,240	MElagatran	THRombin	MESH:C109573	2147	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|amod|END_ENTITY	A dose-ranging study of the oral direct thrombin inhibitor , ximelagatran , and its subcutaneous form , melagatran , compared with dalteparin in the prophylaxis of thromboembolism after hip or knee replacement : METHRO I. MElagatran for THRombin inhibition in Orthopaedic surgery .
11858482	0	MElagatran	217,227	thrombin	40,48	MElagatran	thrombin	MESH:C109573	2147	Chemical	Gene	study|dep|START_ENTITY study|nmod|inhibitor inhibitor|compound|END_ENTITY	A dose-ranging study of the oral direct thrombin inhibitor , ximelagatran , and its subcutaneous form , melagatran , compared with dalteparin in the prophylaxis of thromboembolism after hip or knee replacement : METHRO I. MElagatran for THRombin inhibition in Orthopaedic surgery .
19337958	0	MF-101	0,6	estrogen_receptor	11,28	MF-101	estrogen receptor	null	2099	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	MF-101 , an estrogen_receptor beta agonist for the treatment of vasomotor symptoms in peri - and postmenopausal women .
24001208	0	MFZ	27,30	mGluR5	8,14	MFZ	mGluR5	null	14805(Tax:10090)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	A novel mGluR5 antagonist , MFZ 10-7 , inhibits cocaine-taking and cocaine-seeking behavior in rats .
24789201	8	MG132	1363,1368	CAR	1346,1349	MG132	CAR	MESH:C072553	9970	Chemical	Gene	protein|nmod|START_ENTITY protein|compound|END_ENTITY	The elevation of cytoplasmic CAR protein with MG132 correlated with an increase of HSP70 , and to a lesser extent HSP60 .
20100472	6	MG132	1064,1069	caspase-3	1042,1051	MG132	Cu/Zn-SOD	MESH:C072553	20655(Tax:10090)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	NAC also decreased the caspase-3 activity of MG132 .
8638436	1	MG1363	92,98	chymosin	136,144	MG1363	chymosin	null	529879(Tax:9913)	Chemical	Gene	START_ENTITY|acl|released released|nmod|END_ENTITY	lactis MG1363 , released from bovine beta-casein by chymosin , trypsin or chymotrypsin .
19794038	0	MGCD290	12,19	Hos2	23,27	MGCD290	Hos2	null	852681(Tax:4932)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Activity of MGCD290 , a Hos2 histone deacetylase inhibitor , in combination with azole antifungals against opportunistic fungal pathogens .
25577571	0	MGN1703	0,7	TLR-9	54,59	MGN1703	TLR-9	null	54106	Chemical	Gene	START_ENTITY|appos|agonist agonist|appos|END_ENTITY	MGN1703 , an immunomodulator and toll-like_receptor_9 -LRB- TLR-9 -RRB- agonist : From bench to bedside .
23579026	5	MGO	892,895	G6PD	856,860	MGO	G6PD	CHEBI:31794	2539	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|END_ENTITY	In this study , the activities of isolated G6PD , IDH , and ME were inhibited by MGO -LRB- 0-2 .5 mM , 2-3h , 37 C -RRB- , in a dose - and time-dependent manner , with G6PD and IDH more sensitive to modification than ME .
7929528	0	MI-1544	66,73	gonadotropin-releasing-hormone	23,53	MI-1544	gonadotropin-releasing-hormone	MESH:C040278	2796	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Antitumour effect of a gonadotropin-releasing-hormone antagonist -LRB- MI-1544 -RRB- and its conjugate on human breast_cancer cells and their xenografts .
20944104	0	MI-219	27,33	MDM2	12,16	MI-219	MDM2	MESH:C574930	17246(Tax:10090)	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|Efficacy Efficacy|nmod|END_ENTITY	Efficacy of MDM2 inhibitor MI-219 against lung_cancer cells alone or in combination with MDM2 knockdown , a XIAP inhibitor or etoposide .
22989009	0	MI-219	16,22	p53	87,90	MI-219	p53	MESH:C574930	7157	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	HDM2 antagonist MI-219 -LRB- spiro-oxindole -RRB- , but not Nutlin-3 -LRB- cis-imidazoline -RRB- , regulates p53 through enhanced HDM2 autoubiquitination and degradation in human malignant_B-cell_lymphomas .
19958544	0	MI-319	20,26	MDM2	3,7	MI-319	MDM2	MESH:C548961	4193	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	An MDM2 antagonist -LRB- MI-319 -RRB- restores p53 functions and increases the life span of orally treated follicular_lymphoma bearing animals .
20423286	0	MI-63	31,36	p53	14,17	MI-63	p53	null	7157	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Activation of p53 signaling by MI-63 induces apoptosis in acute_myeloid_leukemia cells .
26852436	0	MISOPROSTOL	36,47	OXYTOCIN	67,75	MISOPROSTOL	OXYTOCIN	MESH:D016595	5020	Chemical	Gene	EFFECT|nmod|START_ENTITY VERSUS|nsubj|EFFECT VERSUS|dobj|END_ENTITY	EFFECT OF PRE-OPERATIVE SUB-LINGUAL MISOPROSTOL VERSUS INTRAVENOUS OXYTOCIN ON CAESAREAN OPERATION BLOOD LOSS .
23677180	0	MJ-56	55,60	EGFR	19,23	MJ-56	EGFR	null	1956	Chemical	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Dual inhibition of EGFR and c-Met kinase activation by MJ-56 reduces metastasis of HT29 human colorectal_cancer cells .
19887545	0	MK-1775	44,51	Wee1	29,33	MK-1775	Wee1	MESH:C549567	7465	Chemical	Gene	kinase|nmod|START_ENTITY kinase|amod|END_ENTITY	Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents .
20107315	0	MK-1775	0,7	Wee1	26,30	MK-1775	Wee1	MESH:C549567	7465	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	MK-1775 , a small molecule Wee1 inhibitor , enhances anti-tumor efficacy of various DNA-damaging agents , including 5-fluorouracil .
21389100	0	MK-1775	0,7	Wee1	18,22	MK-1775	Wee1	MESH:C549567	7465	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	MK-1775 , a potent Wee1 inhibitor , synergizes with gemcitabine to achieve tumor regressions , selectively in p53-deficient pancreatic_cancer xenografts .
21799033	0	MK-1775	0,7	Wee1	17,21	MK-1775	Wee1	MESH:C549567	7465	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	MK-1775 , a novel Wee1 kinase inhibitor , radiosensitizes p53-defective human tumor cells .
23520471	0	MK-1775	19,26	Wee1	0,4	MK-1775	Wee1	MESH:C549567	7465	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Wee1 inhibition by MK-1775 leads to tumor inhibition and enhances efficacy of gemcitabine in human sarcomas .
25964244	0	MK-1775	39,46	Wee1	51,55	MK-1775	Wee1	MESH:C549567	7465	Chemical	Gene	Study|appos|START_ENTITY Study|appos|Inhibitor Inhibitor|compound|END_ENTITY	Phase I Study of Single-Agent AZD1775 -LRB- MK-1775 -RRB- , a Wee1 Kinase Inhibitor , in Patients With Refractory_Solid_Tumors .
22911820	0	MK-2206	67,74	AKT	14,17	MK-2206	AKT	MESH:C548887	11651(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY END_ENTITY|nmod|inhibitor	Inhibition of AKT with the orally active allosteric AKT inhibitor , MK-2206 , sensitizes endometrial_cancer cells to progestin .
22911820	0	MK-2206	67,74	AKT	52,55	MK-2206	AKT	MESH:C548887	11651(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Inhibition of AKT with the orally active allosteric AKT inhibitor , MK-2206 , sensitizes endometrial_cancer cells to progestin .
22911820	6	MK-2206	1076,1083	AKT	1088,1091	MK-2206	PRB	MESH:C548887	18667(Tax:10090)	Chemical	Gene	specificity|nmod|START_ENTITY demonstrating|dobj|specificity demonstrating|nmod|END_ENTITY	MK-2206 inhibited levels of p -LRB- Thr308 -RRB- - AKT and a downstream target , p -LRB- Thr246 -RRB- - PRAS40 , but did not change levels of p -LRB- Thr202/Tyr204 -RRB- ERK or p -LRB- Thr13/Tyr185 -RRB- SAPK/JNK , demonstrating specificity of MK-2206 for AKT .
23147412	0	MK-2206	80,87	AKT	116,119	MK-2206	AKT	MESH:C548887	207	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Neuroendocrine phenotype alteration and growth suppression through apoptosis by MK-2206 , an allosteric inhibitor of AKT , in carcinoid cell lines in vitro .
23588885	0	MK-2206	41,48	AKT	22,25	MK-2206	AKT	MESH:C548887	207	Chemical	Gene	using|dobj|START_ENTITY Combined|acl|using Combined|nmod|END_ENTITY	Combined targeting of AKT and mTOR using MK-2206 and RAD001 is synergistic in the treatment of cholangiocarcinoma .
24002033	0	MK-2206	0,7	AKT	12,15	MK-2206	AKT	MESH:C548887	207	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	MK-2206 , an AKT inhibitor , promotes caspase-independent cell death and inhibits leiomyoma growth .
24252402	0	MK-2206	75,82	AKT	60,63	MK-2206	AKT	MESH:C548887	207	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	A phase 1 study evaluating the combination of an allosteric AKT inhibitor -LRB- MK-2206 -RRB- and trastuzumab in patients with HER2-positive_solid_tumors .
24583795	0	MK-2206	69,76	AKT	54,57	MK-2206	AKT	MESH:C548887	207	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Preclinical and early clinical evaluation of the oral AKT inhibitor , MK-2206 , for the treatment of acute_myelogenous_leukemia .
25336925	0	MK-2206	45,52	AKT	30,33	MK-2206	AKT	MESH:C548887	207	Chemical	Gene	Effects|appos|START_ENTITY Effects|nmod|inhibitor inhibitor|compound|END_ENTITY	Effects of an oral allosteric AKT inhibitor -LRB- MK-2206 -RRB- on human nasopharyngeal_cancer in vitro and in vivo .
25827820	0	MK-2206	17,24	AKT	53,56	MK-2206	AKT	MESH:C548887	207	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Phase 2 study of MK-2206 , an allosteric inhibitor of AKT , as second-line therapy for advanced gastric_and_gastroesophageal_junction_cancer : A SWOG cooperative group trial -LRB- S1005 -RRB- .
27059026	0	MK-2206	28,35	AKT	10,13	MK-2206	AKT	MESH:C548887	207	Chemical	Gene	Cells|compound|START_ENTITY Selective|nmod|Cells Selective|dobj|Inhibition Inhibition|compound|END_ENTITY	Selective AKT Inhibition by MK-2206 Represses Colorectal_Cancer-Initiating_Stem Cells .
20571069	0	MK-2206	0,7	Akt	23,26	MK-2206	Akt	MESH:C548887	207	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	MK-2206 , an allosteric Akt inhibitor , enhances antitumor efficacy by standard chemotherapeutic agents or molecular targeted drugs in vitro and in vivo .
21307130	0	MK-2206	147,154	Akt	76,79	MK-2206	Akt	MESH:C548887	207	Chemical	Gene	cytotoxicity|nmod|START_ENTITY modulating|dobj|cytotoxicity induced|xcomp|modulating induced|nmod|Inhibition Inhibition|compound|END_ENTITY	eEF-2_kinase dictates cross-talk between autophagy and apoptosis induced by Akt Inhibition , thereby modulating cytotoxicity of novel Akt inhibitor MK-2206 .
22057914	0	MK-2206	0,7	Akt	41,44	MK-2206	Akt	MESH:C548887	207	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	MK-2206 , a novel allosteric inhibitor of Akt , synergizes with gefitinib against malignant_glioma via modulating both autophagy and apoptosis .
22338016	0	MK-2206	15,22	Akt	0,3	MK-2206	Akt	MESH:C548887	207	Chemical	Gene	overcome|nsubj|START_ENTITY inhibitors|ccomp|overcome inhibitors|nsubj|END_ENTITY	Akt inhibitors MK-2206 and nelfinavir overcome mTOR inhibitor resistance in diffuse_large_B-cell_lymphoma .
22614243	0	MK-2206	47,54	Akt	32,35	MK-2206	Akt	MESH:C548887	207	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Cytotoxic activity of the novel Akt inhibitor , MK-2206 , in T-cell_acute_lymphoblastic_leukemia .
23917345	0	MK-2206	0,7	Akt	12,15	MK-2206	Akt	MESH:C548887	207	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	MK-2206 , an Akt inhibitor , enhances carboplatinum/paclitaxel efficacy in gastric_cancer cell lines .
24665203	0	MK-2206	49,56	Akt	34,37	MK-2206	Akt	MESH:C548887	207	Chemical	Gene	combination|amod|START_ENTITY combination|nmod|inhibitor inhibitor|compound|END_ENTITY	Additive effect by combination of Akt inhibitor , MK-2206 , and PDGFR inhibitor , tyrphostin_AG_1296 , in suppressing anaplastic_thyroid_carcinoma cell viability and motility .
25114899	0	MK-2206	155,162	Akt	57,60	MK-2206	Akt	MESH:C548887	207	Chemical	Gene	Sensitization|nmod|START_ENTITY Sensitization|nmod|END_ENTITY	Sensitization of cancer cells through reduction of total Akt and downregulation of salinomycin-induced pAkt , pGSk3b , pTSC2 , and p4EBP1 by cotreatment with MK-2206 .
20065019	3	MK-3207	774,781	CGRP	836,840	MK-3207	CGRP	MESH:C548781	700649(Tax:9544)	Chemical	Gene	antagonist|nsubj|START_ENTITY antagonist|nmod|receptors receptors|amod|END_ENTITY	In vitro , MK-3207 is a potent antagonist of the human and rhesus_monkey CGRP receptors -LRB- K -LRB- i -RRB- = 0.024 nM -RRB- .
20065019	0	MK-3207	30,37	calcitonin_gene-related_peptide	66,97	MK-3207	calcitonin gene-related peptide	MESH:C548781	700649(Tax:9544)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Pharmacological properties of MK-3207 , a potent and orally active calcitonin_gene-related_peptide receptor antagonist .
2203881	0	MK-329	72,78	CCK	82,85	MK-329	CCK	MESH:D020109	101096837	Chemical	Gene	promoted|nmod|START_ENTITY shows|ccomp|promoted shows|dep|antagonist antagonist|compound|END_ENTITY	A model of gastric emptying in cats shows solid emptying is promoted by MK-329 : a CCK antagonist .
2326329	0	MK-329	39,45	CCK	15,18	MK-329	CCK	MESH:D020109	397468(Tax:9823)	Chemical	Gene	antagonist|dobj|START_ENTITY antagonist|nsubj|Effects Effects|nmod|receptor receptor|compound|END_ENTITY	Effects of the CCK receptor antagonist MK-329 on food intake in pigs .
2362955	0	MK-329	185,191	CCK	74,77	MK-329	CCK	MESH:D020109	885	Chemical	Gene	L-364|appos|START_ENTITY antagonist|appos|L-364 Effect|nmod|antagonist Effect|nmod|injections injections|nmod|caerulein caerulein|appos|analogue analogue|compound|END_ENTITY	Effect of intracerebroventricular and systemic injections of caerulein , a CCK analogue , on electrical self-stimulation and its interaction with the CCKA receptor antagonist , L-364 ,718 -LRB- MK-329 -RRB- .
2794058	0	MK-329	62,68	CCK	36,39	MK-329	CCK	MESH:D020109	885	Chemical	Gene	Effects|amod|START_ENTITY Effects|nmod|receptor receptor|appos|END_ENTITY	Effects of a novel cholecystokinin -LRB- CCK -RRB- receptor antagonist , MK-329 , on gallbladder contraction and gastric emptying in humans .
2812281	0	MK-329	44,50	CCK	28,31	MK-329	CCK	MESH:D020109	12424(Tax:10090)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	Differential effects of the CCK antagonist , MK-329 , on analgesia induced by morphine , social conflict -LRB- opioid -RRB- and defeat experience -LRB- non-opioid -RRB- in male mice .
8090818	0	MK-329	39,45	CCK	15,18	MK-329	CCK	MESH:D020109	414884(Tax:9031)	Chemical	Gene	antagonist|dobj|START_ENTITY antagonist|nsubj|Effects Effects|nmod|receptor receptor|compound|END_ENTITY	Effects of the CCK receptor antagonist MK-329 on food intake in broiler chickens .
8768856	0	MK-386	10,16	5_alpha-reductase	46,63	MK-386	5 alpha-reductase	MESH:C090665	6715	Chemical	Gene	Effect|nmod|START_ENTITY Effect|amod|END_ENTITY	Effect of MK-386 , a novel inhibitor of type 1 5_alpha-reductase , alone and in combination with finasteride , on serum dihydrotestosterone concentrations in men .
6280900	0	MK-421	64,70	angiotensin_converting_enzyme	24,53	MK-421	angiotensin converting enzyme	MESH:D004656	1636	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|Effects Effects|nmod|END_ENTITY	Effects of the new oral angiotensin_converting_enzyme inhibitor MK-421 in human hypertension .
24900499	0	MK-4256	17,24	SSTR3	35,40	MK-4256	SSTR3	null	20607(Tax:10090)	Chemical	Gene	START_ENTITY|appos|Antagonist Antagonist|compound|END_ENTITY	The Discovery of MK-4256 , a Potent SSTR3 Antagonist as a Potential Treatment of Type 2 Diabetes .
24944750	0	MK-4409	13,20	FAAH	38,42	MK-4409	FAAH	null	2166	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|compound|END_ENTITY	Discovery of MK-4409 , a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic_Pain .
20053775	0	MK-5108	0,7	Aurora-A_kinase	28,43	MK-5108	Aurora-A kinase	MESH:C547876	6790	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	MK-5108 , a highly selective Aurora-A_kinase inhibitor , shows antitumor activity alone and in combination with docetaxel .
20524178	0	MK-5435	136,143	mGluR1	107,113	MK-5435	mGluR1	MESH:C557052	14799(Tax:10090)	Chemical	Gene	occupancy|nmod|START_ENTITY occupancy|amod|END_ENTITY	Synthesis , characterization , and monkey PET studies of -LSB- _____ F -RSB- MK-1312 , a PET tracer for quantification of mGluR1 receptor occupancy by MK-5435 .
20423086	0	MK-5596	154,161	cannabinoid-1_receptor	174,196	MK-5596	cannabinoid-1 receptor	MESH:C550156	1268	Chemical	Gene	START_ENTITY|nmod|agonist agonist|amod|END_ENTITY	Discovery of N - -LSB- -LRB- 4R -RRB- -6 - -LRB- 4-chlorophenyl -RRB- -7 - -LRB- 2,4-dichlorophenyl -RRB- -2,2 - dimethyl-3 ,4 - dihydro-2H-pyrano -LSB- 2,3-b -RSB- pyridin-4-yl -RSB- -5 - methyl-1H-pyrazole-3-carboxamide -LRB- MK-5596 -RRB- as a novel cannabinoid-1_receptor -LRB- CB1R -RRB- inverse agonist for the treatment of obesity .
1952571	0	MK-571	102,108	LTD4_receptor	76,89	MK-571	LTD4 receptor	MESH:C059141	10800	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Leukotriene -LRB- LT -RRB- D4 is involved in antigen-induced asthma : a study with the LTD4_receptor antagonist , MK-571 .
26703673	5	MK-571	822,828	MRP2	806,810	MK-571	BCRP	MESH:C059141	9429	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Glyceollins were shown to inhibit MRP2-mediated CDF transport , with activity similar to the MRP2 inhibitor , MK-571 .
21737272	0	MK-5710	18,25	part_1	249,255	MK-5710	part 1	MESH:C562332	25859	Chemical	Gene	Identification|nmod|START_ENTITY END_ENTITY|nsubj|Identification	Identification of MK-5710 -LRB- -LRB- 8aS -RRB- -8 a-methyl-1 ,3 - dioxo-2 - -LSB- -LRB- 1S ,2 R -RRB- -2 - phenylcyclopropyl -RSB- - N - -LRB- 1-phenyl-1H-pyrazol-5-yl -RRB- hexahydroimid_azo -LSB- 1,5-a -RSB- pyrazine-7 -LRB- 1H -RRB- - carboxamide -RRB- , a potent smoothened antagonist for use in Hedgehog pathway dependent malignancies , part_1 .
22530993	0	MK-626	0,6	dipeptidyl_peptidase-4	10,32	MK-626	dipeptidyl peptidase-4	null	13482(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	MK-626 , a dipeptidyl_peptidase-4 inhibitor , does not improve the hyperglycemia or hyperinsulinemia of nonobese diabetic MKR mice .
8820421	0	MK-639	51,57	cytochrome_P450_3A4	8,27	MK-639	cytochrome P450 3A4	MESH:D019469	1576	Chemical	Gene	metabolism|nmod|START_ENTITY END_ENTITY|nmod|metabolism	Role of cytochrome_P450_3A4 in human metabolism of MK-639 , a potent human immunodeficiency virus protease inhibitor .
9467542	0	MK-677	85,91	GH	68,70	MK-677	GH	MESH:C094817	2688	Chemical	Gene	growth_hormone|amod|START_ENTITY growth_hormone|appos|END_ENTITY	Two-month treatment of obese subjects with the oral growth_hormone -LRB- GH -RRB- secretagogue MK-677 increases GH secretion , fat-free mass , and energy expenditure .
25661195	0	MK-7123	37,44	CXCR2	19,24	MK-7123	CXCR2	null	3579	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|END_ENTITY	The effects of the CXCR2 antagonist , MK-7123 , on bone marrow functions in healthy subjects .
21301326	0	MK-7128	0,7	CB1	17,20	MK-7128	CB1	MESH:C558877	12801(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	MK-7128 , a novel CB1 receptor inverse agonist , improves scopolamine-induced learning_and_memory_deficits in mice .
115561	0	MK-771	11,17	thyrotropin-releasing_hormone	73,102	MK-771	thyrotropin-releasing hormone	MESH:C021597	7200	Chemical	Gene	cord|amod|START_ENTITY Effects|nmod|cord Effects|dep|comparison comparison|nmod|END_ENTITY	Effects of MK-771 on the isolated amphibian spinal cord : comparison with thyrotropin-releasing_hormone .
6431464	0	MK-771	67,73	thyrotropin-releasing_hormone	11,40	MK-771	thyrotropin-releasing hormone	MESH:C021597	7200	Chemical	Gene	Effects|amod|START_ENTITY Effects|nmod|END_ENTITY	Effects of thyrotropin-releasing_hormone -LRB- TRH -RRB- and a TRH analogue , MK-771 , on punished responding of squirrel monkeys .
10340631	0	MK-801	0,6	5-HT_transporter	28,44	MK-801	5-HT transporter	MESH:D016291	6532	Chemical	Gene	interaction|compound|START_ENTITY interaction|nmod|END_ENTITY	MK-801 interaction with the 5-HT_transporter : a real-time study in brain slices using fast cyclic voltammetry .
12089747	0	MK-801	11,17	C-Fos	41,46	MK-801	C-Fos	MESH:D016291	314322(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of MK-801 and morphine on spinal C-Fos expression during the development of neuropathic_pain .
17374554	0	MK-801	56,62	CAPE	89,93	MK-801	CAPE	MESH:D016291	362519(Tax:10116)	Chemical	Gene	effects|compound|START_ENTITY effects|nmod|END_ENTITY	Oxidative stress in prefrontal cortex of rat exposed to MK-801 and protective effects of CAPE .
7968357	0	MK-801	35,41	CRF	23,26	MK-801	CRF	MESH:D016291	81648(Tax:10116)	Chemical	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	Induction of c-fos and CRF mRNA by MK-801 in the parvocellular paraventricular nucleus of the rat hypothalamus .
7620608	0	MK-801	0,6	Fos	19,22	MK-801	Fos	MESH:D016291	396512(Tax:9031)	Chemical	Gene	blockade|compound|START_ENTITY blockade|nmod|END_ENTITY	MK-801 blockade of Fos and Jun expression following passive avoidance training in the chick .
8547590	0	MK-801	0,6	GAD65	39,44	MK-801	GAD65	MESH:D016291	24380(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|levels levels|compound|END_ENTITY	MK-801 decreases striatal and cortical GAD65 mRNA levels .
7957738	0	MK-801	81,87	GFAP	0,4	MK-801	GFAP	MESH:D016291	24387(Tax:10116)	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|expression expression|compound|END_ENTITY	GFAP expression in lumbar spinal cord of naive and neuropathic rats treated with MK-801 .
19125866	0	MK-801	78,84	Ts65Dn	27,33	MK-801	Ts65Dn	MESH:D016291	21101(Tax:10090)	Chemical	Gene	responses|nmod|START_ENTITY responses|nmod|END_ENTITY	Molecular responses of the Ts65Dn and Ts1Cje mouse models of Down syndrome to MK-801 .
8856698	0	MK-801	40,46	bFGF	0,4	MK-801	bFGF	MESH:D016291	2247	Chemical	Gene	effects|nmod|START_ENTITY enhances|dobj|effects enhances|nsubj|END_ENTITY	bFGF enhances the protective effects of MK-801 against ischemic_neuronal_injury in vitro .
14664909	0	MK-801	113,119	brain-derived_neurotrophic_factor	32,65	MK-801	brain-derived neurotrophic factor	MESH:D016291	24225(Tax:10116)	Chemical	Gene	administration|nmod|START_ENTITY inhibited|nmod|administration inhibited|nsubj|expression expression|amod|END_ENTITY	Spatial learning is delayed and brain-derived_neurotrophic_factor mRNA expression inhibited by administration of MK-801 in rats .
8405262	0	MK-801	24,30	brain-derived_neurotrophic_factor	34,67	MK-801	brain-derived neurotrophic factor	MESH:D016291	24225(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|levels levels|amod|END_ENTITY	Differential effects of MK-801 on brain-derived_neurotrophic_factor mRNA levels in different regions of the rat brain .
10534605	0	MK-801	29,35	c-Fos	47,52	MK-801	c-Fos	MESH:D016291	314322(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|amod|END_ENTITY	The NMDA receptor antagonist MK-801 attenuates c-Fos expression in the lumbosacral spinal cord following repetitive noxious and non-noxious colorectal_distention .
11999902	0	MK-801	11,17	c-Fos	49,54	MK-801	c-Fos	MESH:D016291	314322(Tax:10116)	Chemical	Gene	shock|amod|START_ENTITY Effects|nmod|shock Effects|nmod|expression expression|amod|END_ENTITY	Effects of MK-801 and electroconvulsive shock on c-Fos expression in the rat hippocampus and frontal cortex .
15342266	0	MK-801	18,24	c-Fos	35,40	MK-801	c-Fos	MESH:D016291	314322(Tax:10116)	Chemical	Gene	Administration|nmod|START_ENTITY decreases|nsubj|Administration decreases|dobj|expression expression|amod|END_ENTITY	Administration of MK-801 decreases c-Fos expression in the trigeminal_sensory_nuclear_complex but increases it in the midbrain during experimental movement of rat molars .
19121361	0	MK-801	47,53	c-Fos	57,62	MK-801	c-Fos	MESH:D016291	14281(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effects of acute and chronic administration of MK-801 on c-Fos protein expression in mice brain regions implicated in schizophrenia with or without clozapine .
14559159	0	MK-801	0,6	c-fos	39,44	MK-801	c-fos	MESH:D016291	314322(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|induction induction|nmod|levels levels|amod|END_ENTITY	MK-801 attenuates cocaine induction of c-fos and preprodynorphin mRNA levels in Fischer rats .
2110635	0	MK-801	0,6	c-fos	15,20	MK-801	c-fos	MESH:D016291	314322(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|protein protein|amod|END_ENTITY	MK-801 induces c-fos protein in thalamic and neocortical neurons of rat brain .
2124525	0	MK-801	109,115	c-fos	14,19	MK-801	c-fos	MESH:D016291	314322(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY blockade|nmod|treatment Expression|dep|blockade Expression|nmod|protein protein|amod|END_ENTITY	Expression of c-fos protein by N-methyl-D-aspartic_acid in hypothalamus of immature female rats : blockade by MK-801 or neonatal treatment with monosodium_glutamate .
2156188	0	MK-801	0,6	c-fos	65,70	MK-801	c-fos	MESH:D016291	314322(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|accumulation accumulation|amod|END_ENTITY	MK-801 , an antagonist of NMDA receptors , inhibits injury-induced c-fos protein accumulation in rat brain .
2157525	0	MK-801	101,107	c-fos	67,72	MK-801	c-fos	MESH:D016291	2353	Chemical	Gene	induces|nmod|START_ENTITY induces|dobj|reversal reversal|amod|END_ENTITY	Application of potassium_chloride to the brain surface induces the c-fos proto-oncogene : reversal by MK-801 .
8414186	0	MK-801	29,35	c-fos	70,75	MK-801	c-fos	MESH:D016291	14281(Tax:10090)	Chemical	Gene	markedly|nmod:npmod|START_ENTITY reduces|advmod|markedly reduces|dobj|induction induction|nmod|gene gene|amod|END_ENTITY	The NMDA receptor antagonist MK-801 markedly reduces the induction of c-fos gene by haloperidol in the mouse striatum .
8717354	0	MK-801	178,184	c-fos	31,36	MK-801	c-fos	MESH:D016291	314322(Tax:10116)	Chemical	Gene	affected|nmod|START_ENTITY affected|nsubjpass|expression expression|nmod|mRNA mRNA|amod|END_ENTITY	Caffeine-induced expression of c-fos mRNA and NGFI-A mRNA in caudate putamen and in nucleus accumbens are differentially affected by the N-methyl-D-aspartate receptor antagonist MK-801 .
9696479	0	MK-801	29,35	c-fos	62,67	MK-801	c-fos	MESH:D016291	314322(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|amod|END_ENTITY	The NMDA receptor antagonist MK-801 reduces capsaicin-induced c-fos expression within rat trigeminal nucleus caudalis .
9875729	0	MK-801	0,6	c-fos	30,35	MK-801	c-fos	MESH:D016291	14281(Tax:10090)	Chemical	Gene	odours|amod|START_ENTITY induce|nsubj|odours induce|dobj|expression expression|amod|END_ENTITY	MK-801 and male odours induce c-fos expression in the AOB of juvenile female mice .
11118808	0	MK-801	116,122	cyclooxygenase-2	27,43	MK-801	cyclooxygenase-2	MESH:D016291	29527(Tax:10116)	Chemical	Gene	suppression|nmod|START_ENTITY upregulation|dep|suppression upregulation|nmod|photothrombosis photothrombosis|amod|END_ENTITY	Unilateral upregulation of cyclooxygenase-2 following cerebral , cortical photothrombosis in the rat : suppression by MK-801 and co-distribution with enzymes involved in the oxidative stress cascade .
14985832	0	MK-801	1,7	cyclooxygenase-2	34,50	MK-801	cyclooxygenase-2	MESH:D016291	29527(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	-LSB- MK-801 inhibits formalin-induced cyclooxygenase-2 expression in the dorsal horn of the spinal cord in rats -RSB- .
20064280	0	MK-801	20,26	eIF4B	50,55	MK-801	eIF4B	MESH:D016291	300253(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY treatment|nmod|END_ENTITY	Effects of neonatal MK-801 treatment on p70S6K-S6 / eIF4B signal pathways and protein translation in the frontal cortex of the developing rat brain .
21661758	0	MK-8245	73,80	stearoyl-CoA_desaturase	32,55	MK-8245	stearoyl-CoA desaturase	MESH:C561635	6319	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|Development Development|nmod|END_ENTITY	Development of a liver-targeted stearoyl-CoA_desaturase -LRB- SCD -RRB- inhibitor -LRB- MK-8245 -RRB- to establish a therapeutic window for the treatment of diabetes and dyslipidemia .
11251007	0	MK-869	76,82	neurokinin-1	51,63	MK-869	neurokinin-1	MESH:C114556	6863	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Prevention of cisplatin-induced emesis by the oral neurokinin-1 antagonist , MK-869 , in combination with granisetron and dexamethasone or with dexamethasone alone .
22607672	0	MK-8825	0,7	CGRP	32,36	MK-8825	CGRP	MESH:C575097	24241(Tax:10116)	Chemical	Gene	START_ENTITY|dep|antagonist antagonist|compound|END_ENTITY	MK-8825 : a potent and selective CGRP receptor antagonist with good oral activity in rats .
25981890	0	MK-8825	83,90	CGRP	56,60	MK-8825	CGRP	MESH:C575097	796	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|appos|END_ENTITY	A potent and selective calcitonin_gene-related_peptide -LRB- CGRP -RRB- receptor antagonist , MK-8825 , inhibits responses to nociceptive trigeminal activation : Role of CGRP in orofacial_pain .
25981890	0	MK-8825	83,90	calcitonin_gene-related_peptide	23,54	MK-8825	calcitonin gene-related peptide	MESH:C575097	796	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	A potent and selective calcitonin_gene-related_peptide -LRB- CGRP -RRB- receptor antagonist , MK-8825 , inhibits responses to nociceptive trigeminal activation : Role of CGRP in orofacial_pain .
16545574	0	MK-886	51,57	5-LOX	34,39	MK-886	5-LOX	MESH:C060893	240	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|nummod|END_ENTITY	Pre-treatment of HT-29 cells with 5-LOX inhibitor -LRB- MK-886 -RRB- induces changes in cell cycle and increases apoptosis after photodynamic_therapy with hypericin .
18403121	0	MK-886	11,17	5-lipoxygenase	21,35	MK-886	5-lipoxygenase	MESH:C060893	11689(Tax:10090)	Chemical	Gene	START_ENTITY|appos|protein protein|amod|END_ENTITY	Effects of MK-886 , a 5-lipoxygenase activating protein -LRB- FLAP -RRB- inhibitor , and 5-lipoxygenase deficiency on the forced swimming behavior of mice .
9531055	0	MK-886	66,72	5-lipoxygenase	40,54	MK-886	5-lipoxygenase	MESH:C060893	25290(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Suppression of intimal hyperplasia by a 5-lipoxygenase inhibitor , MK-886 : studies with a photochemical model of endothelial injury .
19239910	0	MK-886	0,6	cyclooxygenase-1	72,88	MK-886	cyclooxygenase-1	MESH:C060893	5742	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	MK-886 , an inhibitor of the 5-lipoxygenase-activating protein , inhibits cyclooxygenase-1 activity and suppresses platelet_aggregation .
2550402	0	MK-906	10,16	5_alpha-reductase	29,46	MK-906	5 alpha-reductase	MESH:D018120	6715	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effect of MK-906 , a specific 5_alpha-reductase inhibitor , on serum androgens and androgen conjugates in normal men .
8693970	0	MK-906	51,57	5_alpha-reductase	76,93	MK-906	5 alpha-reductase	MESH:D018120	6715	Chemical	Gene	finasteride|appos|START_ENTITY administration|nmod|finasteride Effect|nmod|administration Effect|appos|inhibitor inhibitor|nmod|END_ENTITY	Effect of long-term administration of finasteride -LRB- MK-906 -RRB- , an inhibitor of 5_alpha-reductase , in patients with benign_prostatic_hyperplasia .
22084170	0	MK1775	0,6	Wee1	20,24	MK1775	Wee1	MESH:C549567	7465	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	MK1775 , a selective Wee1 inhibitor , shows single-agent antitumor activity against sarcoma cells .
7887949	0	MK571	41,46	MRP	70,73	MK571	MRP	MESH:C059141	4363	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	The leukotriene LTD4_receptor antagonist MK571 specifically modulates MRP associated multidrug resistance .
21072897	0	MK615	0,5	RAGE	16,20	MK615	RAGE	null	101669765	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|amod|END_ENTITY	MK615 decreases RAGE expression and inhibits TAGE-induced proliferation in hepatocellular_carcinoma cells .
8624709	0	MK801	11,16	Fos	20,23	MK801	Fos	MESH:D016291	314322(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of MK801 on Fos expression in the rat brainstem after unilateral labyrinthectomy .
2165580	0	MK801	0,5	c-fos	14,19	MK801	c-fos	MESH:D016291	314322(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|protein protein|amod|END_ENTITY	MK801 induces c-fos protein in thalamic and neocortical neurons of rat brain .
23467907	0	MK8033	25,31	c-Met	8,13	MK8033	c-Met	MESH:C581209	4233	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	A novel c-Met inhibitor , MK8033 , synergizes with carboplatin plus paclitaxel to inhibit ovarian_cancer cell growth .
8917356	0	MK886	40,45	5-lipoxygenase	24,38	MK886	5-lipoxygenase	MESH:C060893	240	Chemical	Gene	inhibitor|dep|START_ENTITY inhibitor|nmod|END_ENTITY	An in vivo inhibitor of 5-lipoxygenase , MK886 , at micromolar concentration induces apoptosis in U937 and CML cells .
1588765	0	MK954	78,83	angiotensin_II	42,56	MK954	angiotensin II	MESH:D019808	183	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	-LSB- Antihypertensive effect of a non-peptide angiotensin_II receptor antagonist , MK954 , in patients with essential hypertension -RSB- .
9517445	0	MKC-242	0,7	5-HT1A	17,23	MKC-242	5-HT1A	MESH:C096294	24473(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|nummod|END_ENTITY	MKC-242 , a novel 5-HT1A receptor agonist , facilitates cortical acetylcholine release by a mechanism different from that of 8-OH-DPAT in awake rats .
9863658	0	MKC-242	23,30	5-HT1A_receptor	44,59	MKC-242	5-HT1A receptor	MESH:C096294	3350	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Potentiating action of MKC-242 , a selective 5-HT1A_receptor agonist , on the photic entrainment of the circadian activity rhythm in hamsters .
24312699	0	MKT-077	67,74	Heat_Shock_Protein_70	26,47	MKT-077	Heat Shock Protein 70	MESH:C097880	3308	Chemical	Gene	Inhibitor|appos|START_ENTITY Inhibitor|compound|END_ENTITY	Analogs of the Allosteric Heat_Shock_Protein_70 -LRB- Hsp70 -RRB- Inhibitor , MKT-077 , as Anti-Cancer Agents .
21708173	0	MKT-077	56,63	Hsp70	75,80	MKT-077	Hsp70	MESH:C097880	3308	Chemical	Gene	START_ENTITY|nmod|chaperones chaperones|amod|END_ENTITY	Allosteric drugs : the interaction of antitumor compound MKT-077 with human Hsp70 chaperones .
24312699	0	MKT-077	67,74	Hsp70	49,54	MKT-077	Hsp70	MESH:C097880	3308	Chemical	Gene	Inhibitor|appos|START_ENTITY Inhibitor|appos|END_ENTITY	Analogs of the Allosteric Heat_Shock_Protein_70 -LRB- Hsp70 -RRB- Inhibitor , MKT-077 , as Anti-Cancer Agents .
2557748	0	MK_421	72,78	angiotensin_II	23,37	MK 421	angiotensin II	MESH:D004656	24179(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nmod|effect	Role of the endogenous angiotensin_II in the antihypertensive effect of MK_421 in rats made hypertensive by norepinephrine or vasopressin .
6185790	0	MK_421	30,36	angiotensin_II	38,52	MK 421	angiotensin II	MESH:D004656	183	Chemical	Gene	therapy|nmod|START_ENTITY therapy|dep|END_ENTITY	Antihypertensive therapy with MK_421 : angiotensin_II -- renin relationships to evaluate efficacy of converting enzyme blockade .
12392213	0	MK_801	0,6	c-Fos	18,23	MK 801	c-Fos	MESH:D016291	314322(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|amod|END_ENTITY	MK_801 attenuates c-Fos and c-Jun expression after in vitro ischemia in rat neuronal cell cultures but not in PC 12 cells .
7886620	0	MK_801	23,29	c-fos	49,54	MK 801	c-fos	MESH:D016291	314322(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Differential effect of MK_801 and scopolamine on c-fos expression induced by L-dopa in the striatum of 6-hydroxydopamine lesioned rats .
14985055	0	ML-9	0,4	myosin_light_chain_kinase	8,33	ML-9	myosin light chain kinase	MESH:C056218	100714177	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	ML-9 , a myosin_light_chain_kinase inhibitor , reduces intracellular Ca2 + concentration in guinea_pig trachealis .
2703279	0	ML-9	59,63	myosin_light_chain_kinase	90,115	ML-9	myosin light chain kinase	MESH:C056218	4638	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Inhibition of natural killer cell-mediated cytotoxicity by ML-9 , a selective inhibitor of myosin_light_chain_kinase .
23658967	3	ML224	620,625	TSHR	598,602	ML224	TSHR	null	7253	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Preliminary structure-activity relationship studies led to the discovery of a selective TSHR inverse agonist , ML224 , which could be a useful tool for studying TSHR functions ; it could also be a potential lead for development of drugs to treat TSHR-mediated hyperthyroidism caused by constitutively activating mutations or stimulating auto-antibodies associated with Graves ____ disease .
23905201	0	ML309	0,5	IDH1	42,46	ML309	IDH1	null	3417	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	ML309 : A potent inhibitor of R132H mutant IDH1 capable of reducing 2-hydroxyglutarate production in U87 MG_glioblastoma cells The emergence of the role of isocitrate_dehydrogenase -LRB- IDH -RRB- in cancer resulted from genomic sequencing for 22 glioma genomes that found recurrent mutation of IDH1 on chromosome 2q33 .
24260783	0	ML324	13,18	JMJD2	22,27	ML324	JMJD2	null	9682	Chemical	Gene	Discovery|nmod|START_ENTITY Discovery|appos|inhibitor inhibitor|compound|END_ENTITY	Discovery of ML324 , a JMJD2 demethylase inhibitor with demonstrated antiviral activity A critical and dynamic epigenetic post-translational modification involves N -LRB- -RRB- - methylation of histone lysine residues by histone methyltransferases .
24241037	0	ML3403	46,52	p38	79,82	ML3403	p38	MESH:C522498	81649(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|MAP MAP|amod|END_ENTITY	Efficacy and gastrointestinal tolerability of ML3403 , a selective inhibitor of p38 MAP kinase and CBS-3595 , a dual inhibitor of p38 MAP kinase and phosphodiesterase 4 in CFA-induced arthritis in rats .
17344341	0	ML3403	20,26	p38_mitogen-activated_protein_kinase	152,188	ML3403	p38 mitogen-activated protein kinase	MESH:C522498	1432	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Pharmacokinetics of ML3403 -LRB- -LCB- 4 - -LSB- 5 - -LRB- 4-fluorophenyl -RRB- -2 - methylsulfanyl-3H-imidazol-4-yl -RSB- - pyridin-2-yl -RCB- - -LRB- 1-phenylethyl -RRB- - amine -RRB- , a 4-Pyridinylimidazole-type p38_mitogen-activated_protein_kinase inhibitor .
25946346	0	ML358	13,18	SKN-1	64,69	ML358	SKN-1	null	177343(Tax:6239)	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|nmod|Pathway Pathway|compound|END_ENTITY	Discovery of ML358 , a Selective Small Molecule Inhibitor of the SKN-1 Pathway Involved in Drug Detoxification and Resistance in Nematodes .
25946346	0	ML358	13,18	SKN-1	64,69	ML358	SKN-1	null	177343(Tax:6239)	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|nmod|Pathway Pathway|compound|END_ENTITY	Discovery of ML358 , a Selective Small Molecule Inhibitor of the SKN-1 Pathway Involved in Drug Detoxification and Resistance in Nematodes .
25210004	0	ML395	48,53	PLD2	32,36	ML395	PLD2	null	5338	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Discovery of a highly selective PLD2 inhibitor -LRB- ML395 -RRB- : a new probe with improved physiochemical properties and broad-spectrum antiviral activity against influenza strains .
26887042	0	MLN-8237	0,8	aurora_A_and_B	30,44	MLN-8237	aurora A and B	MESH:C550258	6790;9212	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	MLN-8237 ; A dual inhibitor of aurora_A_and_B in soft tissue sarcomas .
23085766	0	MLN0128	21,28	TORC1/2	38,45	MLN0128	TORC1/2	null	23373;200186	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Investigational drug MLN0128 , a novel TORC1/2 inhibitor , demonstrates potent oral antitumor activity in human breast_cancer xenograft models .
23386687	0	MLN0128	77,84	mTOR	45,49	MLN0128	mTOR	null	21977(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Equivalent benefit of rapamycin and a potent mTOR ATP-competitive inhibitor , MLN0128 -LRB- INK128 -RRB- , in a mouse model of tuberous_sclerosis .
24243565	0	MLN0128	48,55	mTOR	32,36	MLN0128	mTOR	null	21977(Tax:10090)	Chemical	Gene	trial|appos|START_ENTITY trial|nmod|inhibitor inhibitor|compound|END_ENTITY	Preclinical trial of a new dual mTOR inhibitor , MLN0128 , using renal_cell_carcinoma tumorgrafts .
22609854	0	MLN0905	0,7	plk1	26,30	MLN0905	plk1	MESH:C570910	5347	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	MLN0905 , a small-molecule plk1 inhibitor , induces antitumor responses in human models of diffuse large B-cell_lymphoma .
17020997	0	MLN120B	0,7	IkappaB_kinase_beta	17,36	MLN120B	IkappaB kinase beta	null	3551	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	MLN120B , a novel IkappaB_kinase_beta inhibitor , blocks multiple_myeloma cell growth in vitro and in vivo .
17715391	0	MLN3897	0,7	CCR1	17,21	MLN3897	CCR1	null	1230	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	MLN3897 , a novel CCR1 inhibitor , impairs osteoclastogenesis and inhibits the interaction of multiple_myeloma cells and osteoclasts .
24713927	0	MLN4924	0,7	AKT	38,41	MLN4924	AKT	MESH:C539933	207	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	MLN4924 , an NAE inhibitor , suppresses AKT and mTOR signaling via upregulation of REDD1 in human myeloma cells .
26895833	0	MLN4924	0,7	IFN-b	72,77	MLN4924	IFN-b	MESH:C539933	15977(Tax:10090)	Chemical	Gene	Attenuates|nsubj|START_ENTITY Attenuates|dobj|Production Production|amod|END_ENTITY	MLN4924 , a First-in-Class NEDD8-Activating Enzyme Inhibitor , Attenuates IFN-b Production .
24691136	0	MLN4924	77,84	UBA3	13,17	MLN4924	UBA3	MESH:C539933	9039	Chemical	Gene	confer|nmod|START_ENTITY confer|nsubj|Mutations Mutations|nmod|END_ENTITY	Mutations in UBA3 confer resistance to the NEDD8-activating enzyme inhibitor MLN4924 in human leukemic cells .
25337909	0	MLN4924	89,96	UBA3	25,29	MLN4924	UBA3	MESH:C539933	9039	Chemical	Gene	Resistance|nmod|START_ENTITY Resistance|compound|END_ENTITY	Correction : Mutations in UBA3 Confer Resistance to the NEDD8-Activating Enzyme Inhibitor MLN4924 in Human Leukemic Cells .
15242881	0	MLN518	11,17	FLT3	26,30	MLN518	FLT3	MESH:C464670	2322	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of MLN518 , a dual FLT3 and KIT inhibitor , on normal and malignant hematopoiesis .
17438137	0	MLN8054	0,7	Aurora_A	39,47	MLN8054	Aurora A	MESH:C518940	6790	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	MLN8054 , a small-molecule inhibitor of Aurora_A , causes spindle pole and chromosome congression defects leading to aneuploidy .
26101564	0	MLN8054	0,7	Aurora_A	61,69	MLN8054	Aurora A	MESH:C518940	6790	Chemical	Gene	START_ENTITY|dep|Discovery Discovery|nmod|Inhibitors Inhibitors|compound|END_ENTITY	MLN8054 and Alisertib -LRB- MLN8237 -RRB- : Discovery of Selective Oral Aurora_A Inhibitors .
20607239	0	MLN8054	17,24	Aurora_A_kinase	51,66	MLN8054	Aurora A kinase	MESH:C518940	6790	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Phase 1 study of MLN8054 , a selective inhibitor of Aurora_A_kinase in patients with advanced solid tumors .
20426425	0	MLN8054	103,110	aurora_A	15,23	MLN8054	aurora A	MESH:C518940	6790	Chemical	Gene	inhibitors|dobj|START_ENTITY inhibitors|nsubj|mutants mutants|compound|END_ENTITY	Drug-resistant aurora_A mutants for cellular target validation of the small molecule kinase inhibitors MLN8054 and MLN8237 .
21514073	0	MLN8054	0,7	aurora_kinase_a	39,54	MLN8054	aurora kinase a	MESH:C518940	6790	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	MLN8054 , a small molecule inhibitor of aurora_kinase_a , sensitizes androgen-resistant_prostate_cancer to radiation .
22374334	0	MLN8237	20,27	Aurora_A	0,8	MLN8237	Aurora A	MESH:C550258	20878(Tax:10090)	Chemical	Gene	lethal|dep|START_ENTITY inhibitor|ccomp|lethal inhibitor|nsubj|END_ENTITY	Aurora_A inhibitor -LRB- MLN8237 -RRB- plus vincristine plus rituximab is synthetic lethal and a potential curative therapy in aggressive B-cell_non-Hodgkin_lymphoma .
26101564	0	MLN8237	23,30	Aurora_A	61,69	MLN8237	Aurora A	MESH:C550258	6790	Chemical	Gene	MLN8054|appos|START_ENTITY MLN8054|dep|Discovery Discovery|nmod|Inhibitors Inhibitors|compound|END_ENTITY	MLN8054 and Alisertib -LRB- MLN8237 -RRB- : Discovery of Selective Oral Aurora_A Inhibitors .
26567366	0	MLN8237	32,39	Aurora_A	12,20	MLN8237	Aurora A	MESH:C550258	6790	Chemical	Gene	Inhibitor|appos|START_ENTITY Inhibitor|compound|END_ENTITY	Correction : Aurora_A Inhibitor -LRB- MLN8237 -RRB- plus Vincristine plus Rituximab Is Synthetic Lethal and a Potential Curative Therapy in Aggressive_B-cell_Non-Hodgkin_Lymphoma .
26689566	0	MLN8237	99,106	Aurora_A_Kinase	62,77	MLN8237	Aurora A Kinase	MESH:C550258	6790	Chemical	Gene	Effect|appos|START_ENTITY Effect|nmod|Food Food|nmod|Pharmacokinetics Pharmacokinetics|nmod|Alisertib Alisertib|compound|END_ENTITY	Effect of Food on the Pharmacokinetics of the Investigational Aurora_A_Kinase Inhibitor Alisertib -LRB- MLN8237 -RRB- in Patients with Advanced_Solid_Tumors .
22772063	0	MLN8237	18,25	Aurora_A_kinase	58,73	MLN8237	Aurora A kinase	MESH:C550258	6790	Chemical	Gene	study|nmod|START_ENTITY study|appos|inhibitor inhibitor|compound|END_ENTITY	Phase II study of MLN8237 -LRB- alisertib -RRB- , an investigational Aurora_A_kinase inhibitor , in patients with platinum-resistant or - refractory epithelial ovarian , _ fallopian_tube , or primary_peritoneal_carcinoma .
24352795	0	MLN8237	17,24	Aurora_A_kinase	42,57	MLN8237	Aurora A kinase	MESH:C550258	6790	Chemical	Gene	study|nmod|START_ENTITY study|dep|inhibitor inhibitor|amod|END_ENTITY	Phase I study of MLN8237 -- investigational Aurora_A_kinase inhibitor -- in relapsed/refractory multiple myeloma , non-Hodgkin_lymphoma and chronic_lymphocytic_leukemia .
24879333	0	MLN8237	53,60	Aurora_A_kinase	16,31	MLN8237	Aurora A kinase	MESH:C550258	6790	Chemical	Gene	alisertib|appos|START_ENTITY alisertib|compound|END_ENTITY	Investigational Aurora_A_kinase inhibitor alisertib -LRB- MLN8237 -RRB- as an enteric-coated tablet formulation in non-hematologic_malignancies : Phase 1 dose-escalation study .
25068104	0	MLN8237	85,92	Aurora_A_kinase	48,63	MLN8237	Aurora A kinase	MESH:C550258	6790	Chemical	Gene	alisertib|appos|START_ENTITY alisertib|amod|END_ENTITY	An exploratory phase 2 study of investigational Aurora_A_kinase inhibitor alisertib -LRB- MLN8237 -RRB- in acute_myelogenous_leukemia and myelodysplastic_syndromes .
26073352	0	MLN8237	98,105	Aurora_A_kinase	61,76	MLN8237	Aurora A kinase	MESH:C550258	6790	Chemical	Gene	bioavailability|appos|START_ENTITY bioavailability|nmod|oral_solution oral_solution|nmod|alisertib alisertib|compound|END_ENTITY	Relative bioavailability of a prototype oral_solution of the Aurora_A_kinase inhibitor alisertib -LRB- MLN8237 -RRB- in patients with advanced solid tumors .
22988055	0	MLN8237	53,60	Aurora_kinase_A	124,139	MLN8237	Aurora kinase A	MESH:C550258	6790	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Pediatric phase I trial and pharmacokinetic study of MLN8237 , an investigational oral selective small-molecule inhibitor of Aurora_kinase_A : a Children 's Oncology Group Phase I Consortium study .
22016509	0	MLN8237	31,38	aurora_A	88,96	MLN8237	aurora A	MESH:C550258	6790	Chemical	Gene	Alisertib|appos|START_ENTITY Alisertib|appos|inhibitor inhibitor|nmod|END_ENTITY	Characterization of Alisertib -LRB- MLN8237 -RRB- , an investigational small-molecule inhibitor of aurora_A kinase using novel in vivo pharmacodynamic assays .
22753585	0	MLN8237	49,56	aurora_a_kinase	94,109	MLN8237	aurora a kinase	MESH:C550258	6790	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Phase I pharmacokinetic/pharmacodynamic study of MLN8237 , an investigational , oral , selective aurora_a_kinase inhibitor , in patients with advanced solid tumors .
15955032	0	MM-77	53,58	5HT1A	35,40	MM-77	5HT1A	MESH:C413583	15550(Tax:10090)	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|nummod|END_ENTITY	A comparison of the effects of the 5HT1A antagonists MM-77 and WAY-100635 on the mouse isolated vasa deferentia .
2578769	0	MMC	64,67	PEP	98,101	MMC	PEP	CHEBI:27504	5047	Chemical	Gene	administration|compound|START_ENTITY administration|appos|END_ENTITY	-LSB- Effects of bronchial artery infusion -LRB- B-AI -RRB- with single use of MMC after intravenous peplomycin -LRB- PEP -RRB- administration in lung_cancer -RSB- .
26293053	2	MMF	889,892	IL-15	923,928	MMF	NKG2D	CHEBI:8764	22914	Chemical	Gene	START_ENTITY|nmod|presence presence|nmod|END_ENTITY	After treatment of MMF in the presence or absence of IL-15 , HBsAg titer was also measured in C57BL/6JTgN -LRB- A1b1HBV -RRB- 44Bri -RRB- transgenic_mice .
10693638	0	MMF	101,104	TGF-beta1	24,33	MMF	TGF-beta1	CHEBI:8764	7040	Chemical	Gene	converted|nmod|START_ENTITY converted|nsubj|study study|nmod|levels levels|compound|END_ENTITY	A longitudinal study of TGF-beta1 protein levels in renal allograft recipients converted from CsA to MMF or AZA .
9552223	0	MMS-68	102,108	mucin	82,87	MMS-68	mucin	null	100508689	Chemical	Gene	secretagogue|appos|START_ENTITY secretagogue|compound|END_ENTITY	Mucin secretion in inflammatory_bowel_disease : comparison of a macrophage-derived mucin secretagogue -LRB- MMS-68 -RRB- to conventional secretagogues .
25785740	0	MNL8054	23,30	Aurora_A	0,8	MNL8054	Aurora A	null	41446(Tax:7227)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Aurora_A inhibition by MNL8054 promotes centriole elongation during Drosophila male meiosis .
12093789	7	MOCA	1212,1216	APP	1220,1223	MOCA	APP	MESH:D008753	351	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	It is concluded that MOCA plays a major role in APP metabolism and that the effect of MOCA on APP secretion and cell adhesion is a downstream consequence of MOCA-directed APP catabolism .
21741620	0	MP-124	0,6	PARP-1	47,53	MP-124	PARP-1	MESH:C560412	142	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|appos|END_ENTITY	MP-124 , a novel poly -LRB- ADP-ribose -RRB- _ polymerase-1 -LRB- PARP-1 -RRB- inhibitor , ameliorates ischemic brain_damage in a non-human primate model .
25868125	0	MP-124	49,55	PARP-1	96,102	MP-124	PARP-1	MESH:C560412	25591(Tax:10116)	Chemical	Gene	damage|nmod|START_ENTITY _|nsubj|damage _|dobj|inhibitor inhibitor|appos|END_ENTITY	Chromosomal damage and micronucleus induction by MP-124 , a novel poly -LRB- ADP-ribose -RRB- _ polymerase-1 -LRB- PARP-1 -RRB- inhibitor : Evidence for a non-DNA-reactive mode of action .
15853225	0	MPA	107,110	CPT-11	99,105	MPA	CPT-11	null	963084(Tax:115711)	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- A case of recurrent breast_cancer with bone_metastasis causing pancytopenia -- efficacy of low-dose CPT-11 + MPA -RSB- .
22913511	0	MPC-3100	137,145	Hsp90	163,168	MPC-3100	Hsp90	MESH:C577050	3320	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Discovery of -LRB- 2S -RRB- -1 - -LSB- 4 - -LRB- 2 - -LCB- 6-amino-8 - -LSB- -LRB- 6-bromo-1 ,3 - benzodioxol-5-yl -RRB- sulfanyl -RSB- -9 H-purin-9-yl -RCB- ethyl -RRB- piperidin-1-yl -RSB- -2 - hydroxypropan-1-one -LRB- MPC-3100 -RRB- , a purine-based Hsp90 inhibitor .
26483201	0	MPC-3100	64,72	Hsp90	47,52	MPC-3100	Hsp90	MESH:C577050	3320	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Discovery of an l-alanine_ester prodrug of the Hsp90 inhibitor , MPC-3100 .
15189351	0	MPEP	49,53	mGlu5R	31,37	MPEP	mGlu5R	CHEBI:64159	108071(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|antagonist antagonist|amod|END_ENTITY	Neuroprotective effects of the mGlu5R antagonist MPEP towards quinolinic_acid-induced striatal toxicity : involvement of pre - and post-synaptic mechanisms and lack of direct NMDA blocking activity .
15880742	0	MPEP	45,49	mGlu5R	197,203	MPEP	mGlu5R	CHEBI:64159	108071(Tax:10090)	Chemical	Gene	treatment|nmod|START_ENTITY reduces|nsubj|treatment reduces|parataxis|relevance relevance|nmod|effects effects|nmod|blockade blockade|amod|END_ENTITY	Chronic treatment with the mGlu5R antagonist MPEP reduces the functional effects of the mGlu5R agonist CHPG in the striatum of 6-hydroxydopamine-lesioned rats : possible relevance to the effects of mGlu5R blockade in Parkinson 's _ disease .
15880742	0	MPEP	45,49	mGlu5R	88,94	MPEP	mGlu5R	CHEBI:64159	108071(Tax:10090)	Chemical	Gene	treatment|nmod|START_ENTITY reduces|nsubj|treatment reduces|dobj|effects effects|nmod|agonist agonist|amod|END_ENTITY	Chronic treatment with the mGlu5R antagonist MPEP reduces the functional effects of the mGlu5R agonist CHPG in the striatum of 6-hydroxydopamine-lesioned rats : possible relevance to the effects of mGlu5R blockade in Parkinson 's _ disease .
12527470	0	MPEP	44,48	mGluR5	54,60	MPEP	mGluR5	CHEBI:64159	14805(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Morphine conditioned reward is inhibited by MPEP , the mGluR5 antagonist .
12682710	0	MPEP	22,26	mGluR5	4,10	MPEP	mGluR5	CHEBI:64159	14805(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|antagonist antagonist|amod|END_ENTITY	The mGluR5 antagonist MPEP decreased nicotine self-administration in rats and mice .
12907309	0	MPEP	26,30	mGluR5	44,50	MPEP	mGluR5	C121465	14805(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Neuroprotective action of MPEP , a selective mGluR5 antagonist , in methamphetamine-induced dopaminergic neurotoxicity is associated with a decrease in dopamine outflow and inhibition of hyperthermia in rats .
15024550	0	MPEP	59,63	mGluR5	4,10	MPEP	mGluR5	CHEBI:64159	14805(Tax:10090)	Chemical	Gene	pyridine|appos|START_ENTITY potentiates|nsubj|pyridine 2-methyl-6|parataxis|potentiates 2-methyl-6|amod|END_ENTITY	The mGluR5 antagonist 2-methyl-6 - -LRB- phenylethynyl -RRB- - pyridine -LRB- MPEP -RRB- potentiates PCP-induced cognitive_deficits in rats .
15381829	0	MPEP	22,26	mGluR5	31,37	MPEP	mGluR5	CHEBI:64159	14805(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Opposite influence of MPEP , an mGluR5 antagonist , on the locomotor_hyperactivity induced by PCP and amphetamine .
15591648	0	MPEP	10,14	mGluR5	28,34	MPEP	mGluR5	CHEBI:64159	14805(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Effect of MPEP , a selective mGluR5 antagonist , on the antielectroshock activity of conventional antiepileptic drugs .
15686891	0	MPEP	99,103	mGluR5	65,71	MPEP	mGluR5	CHEBI:64159	14805(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Functionalization Functionalization|nmod|position position|nmod|ring ring|nmod|antagonists antagonists|amod|END_ENTITY	Functionalization at position 3 of the phenyl ring of the potent mGluR5 noncompetitive antagonists MPEP .
15694927	0	MPEP	186,190	mGluR5	168,174	MPEP	mGluR5	CHEBI:64159	14805(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|treatment treatment|nmod|antagonist antagonist|amod|END_ENTITY	Protection but maintained dysfunction of nigral dopaminergic nerve cell bodies and striatal dopaminergic terminals in MPTP-lesioned mice after acute treatment with the mGluR5 antagonist MPEP .
15821750	0	MPEP	51,55	mGluR5	32,38	MPEP	mGluR5	CHEBI:64159	14805(Tax:10090)	Chemical	Gene	antagonists|acl:relcl|START_ENTITY antagonists|amod|END_ENTITY	Neuroprotective activity of the mGluR5 antagonists MPEP and MTEP against acute excitotoxicity differs and does not reflect actions at mGluR5 receptors .
15950993	0	MPEP	82,86	mGluR5	75,81	MPEP	mGluR5	CHEBI:64159	14805(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|action action|nmod|antagonist antagonist|nmod|END_ENTITY	Anticonvulsant action of an antagonist of metabotropic glutamate receptors mGluR5 MPEP in immature rats .
16023685	0	MPEP	52,56	mGluR5	33,39	MPEP	mGluR5	CHEBI:64159	14805(Tax:10090)	Chemical	Gene	attenuated|nsubj|START_ENTITY antagonist|ccomp|attenuated antagonist|nsubj|receptor receptor|appos|END_ENTITY	Metabotropic glutamate receptor -LRB- mGluR5 -RRB- antagonist MPEP attenuated cue - and schedule-induced reinstatement of nicotine self-administration behavior in rats .
16382209	0	MPEP	109,113	mGluR5	127,133	MPEP	mGluR5	CHEBI:64159	14805(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Application of magnetic resonance diffusion anisotropy imaging for the assessment neuroprotecting effects of MPEP , a selective mGluR5 antagonist , on the rat spinal_cord_injury in vivo .
17126859	0	MPEP	37,41	mGluR5	19,25	MPEP	mGluR5	CHEBI:64159	14805(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|antagonist antagonist|amod|END_ENTITY	The effects of the mGluR5 antagonist MPEP and the mGluR2/3 antagonist LY341495 on rats ' performance in the 5-choice serial reaction time task .
18242586	0	MPEP	33,37	mGluR5	88,94	MPEP	mGluR5	CHEBI:64159	14805(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|nmod|END_ENTITY	Neuroprotective effect caused by MPEP , an antagonist of metabotropic glutamate receptor mGluR5 , on seizures induced by pilocarpine in 21-day-old rats .
18619984	0	MPEP	174,178	mGluR5	156,162	MPEP	mGluR5	CHEBI:64159	14805(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|blockade blockade|nmod|antagonist antagonist|amod|END_ENTITY	Cue-induced reinstatement of alcohol-seeking behavior is associated with increased ERK1/2 phosphorylation in specific limbic brain regions : blockade by the mGluR5 antagonist MPEP .
19815944	0	MPEP	35,39	mGluR5	60,66	MPEP	mGluR5	CHEBI:64159	14805(Tax:10090)	Chemical	Gene	2-Methyl-6-phenylethynyl-pyridine|appos|START_ENTITY 2-Methyl-6-phenylethynyl-pyridine|appos|antagonist antagonist|amod|END_ENTITY	2-Methyl-6-phenylethynyl-pyridine -LRB- MPEP -RRB- , a non-competitive mGluR5 antagonist , differentially affects the anticonvulsant activity of four conventional antiepileptic drugs against amygdala-kindled seizures in rats .
20422403	0	MPEP	83,87	mGluR5	19,25	MPEP	mGluR5	CHEBI:64159	14805(Tax:10090)	Chemical	Gene	pyridine|appos|START_ENTITY phenylethynyl|dep|pyridine effects|dep|phenylethynyl effects|nmod|receptor receptor|amod|END_ENTITY	The effects of the mGluR5 receptor antagonist 6-methyl-2 - -LRB- phenylethynyl -RRB- - pyridine -LRB- MPEP -RRB- on behavioural responses to nicotine .
20579001	0	MPEP	59,63	mGluR5	4,10	MPEP	mGluR5	CHEBI:64159	14805(Tax:10090)	Chemical	Gene	place|appos|START_ENTITY -|dep|place -|amod|END_ENTITY	The mGluR5 antagonist 2-methyl-6 - -LRB- phenylethynyl -RRB- - pyridine -LRB- MPEP -RRB- potentiates conditioned place preference induced by various addictive and non-addictive drugs in rats .
21216262	0	MPEP	83,87	mGluR5	19,25	MPEP	mGluR5	CHEBI:64159	14805(Tax:10090)	Chemical	Gene	pyridine|appos|START_ENTITY phenylethynyl|dep|pyridine effects|dep|phenylethynyl effects|nmod|receptor receptor|amod|END_ENTITY	The effects of the mGluR5 receptor antagonist 6-methyl-2 - -LRB- phenylethynyl -RRB- - pyridine -LRB- MPEP -RRB- on the stimulation of dopamine release evoked by nicotine in the rat brain .
24279870	0	MPEP	33,37	mGluR5	15,21	MPEP	mGluR5	CHEBI:64159	14805(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|antagonist antagonist|amod|END_ENTITY	Effects of the mGluR5 antagonist MPEP on ethanol withdrawal induced anxiety-like_syndrome in rats .
25933979	0	MPEP	116,120	mGluR5	24,30	MPEP	mGluR5	C121465	14805(Tax:10090)	Chemical	Gene	MTEP|parataxis|START_ENTITY MTEP|nsubj|concentrations concentrations|nmod|modulator modulator|amod|END_ENTITY	Brain concentrations of mGluR5 negative allosteric modulator MTEP in relation to receptor occupancy - Comparison to MPEP .
26478256	0	MPEP	13,17	mGluR5	31,37	MPEP	mGluR5	C121465	14805(Tax:10090)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|appos|antagonist antagonist|amod|END_ENTITY	Influence of MPEP -LRB- a selective mGluR5 antagonist -RRB- on the anticonvulsant action of novel antiepileptic drugs against maximal electroshock-induced seizures in mice .
14666119	0	MPEP	64,68	neuropeptide_Y	78,92	MPEP	neuropeptide Y	CHEBI:64159	24604(Tax:10116)	Chemical	Gene	involves|nsubj|START_ENTITY involves|dobj|END_ENTITY	In the amygdala anxiolytic action of mGlu5 receptors antagonist MPEP involves neuropeptide_Y but not GABAA signaling .
21980130	0	MPI-0479605	58,69	Mps1	120,124	MPI-0479605	Mps1	MESH:C571997	7272	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Characterization of the cellular and antitumor effects of MPI-0479605 , a small-molecule inhibitor of the mitotic kinase Mps1 .
26312747	0	MPLA	79,83	Th1	92,95	MPLA	Th1	null	57314(Tax:10090)	Chemical	Gene	Responses|compound|START_ENTITY Responses|compound|END_ENTITY	A Novel Prime and Boost Regimen of HIV Virus-Like Particles with TLR4 Adjuvant MPLA Induces Th1 Oriented Immune Responses against HIV .
15178162	0	MPOA	34,38	Androgen_receptor	0,17	MPOA	Androgen receptor	null	24208(Tax:10116)	Chemical	Gene	blockade|nmod|START_ENTITY blockade|amod|END_ENTITY	Androgen_receptor blockade in the MPOA or VMN : effects on male sociosexual_behaviors .
19254732	0	MPP	41,44	ERalpha	21,28	MPP	ERalpha	CHEBI:34761	24890(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	Effect of a putative ERalpha antagonist , MPP , on food intake in cycling and ovariectomized rats .
26587975	0	MPT0G009	36,44	tumor_necrosis_factor-related_apoptosis-inducing_ligand	109,164	MPT0G009	tumor necrosis factor-related apoptosis-inducing ligand	MESH:C000597683	8743	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Novel histone deacetylase inhibitor MPT0G009 induces cell apoptosis and synergistic anticancer activity with tumor_necrosis_factor-related_apoptosis-inducing_ligand against human hepatocellular_carcinoma .
22198382	0	MPTP	66,70	Akt	22,25	MPTP	Akt	MESH:D015632	11651(Tax:10090)	Chemical	Gene	mediated|nmod|START_ENTITY END_ENTITY|acl|mediated	Redox modification of Akt mediated by the dopaminergic neurotoxin MPTP , in mouse midbrain , leads to down-regulation of pAkt .
17017526	0	MPTP	82,86	CYP_2E1	69,76	MPTP	CYP 2E1	MESH:D015632	13106(Tax:10090)	Chemical	Gene	toxicity|compound|START_ENTITY END_ENTITY|nmod|toxicity	Cytochrome_P450 and Parkinson 's _ disease : protective role of neuronal CYP_2E1 from MPTP toxicity .
9756328	0	MPTP	107,111	Glial_cell_line-derived_neurotrophic_factor	0,43	MPTP	Glial cell line-derived neurotrophic factor	MESH:D015632	14573(Tax:10090)	Chemical	Gene	tetrahydropyridine|appos|START_ENTITY protects|dep|tetrahydropyridine protects|compound|END_ENTITY	Glial_cell_line-derived_neurotrophic_factor protects against 1-methyl-4-phenyl-1 ,2,3,6 - tetrahydropyridine -LRB- MPTP -RRB- - induced neurotoxicity in C57BL/6 mice .
16154791	0	MPTP	100,104	IL1-beta	48,56	MPTP	IL1-beta	MESH:D015632	3553	Chemical	Gene	administration|compound|START_ENTITY END_ENTITY|nmod|administration	Increased plasma levels of TNF-alpha but not of IL1-beta in MPTP-treated monkeys one year after the MPTP administration .
25450660	0	MPTP	78,82	POLG	92,96	MPTP	POLG	MESH:D015632	18975(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|compound|END_ENTITY	Somatic mitochondrial DNA mutations do not increase neuronal vulnerability to MPTP in young POLG mutator mice .
17610816	0	MPTP	49,53	Prx2	41,45	MPTP	Prx2	MESH:D015632	51450	Chemical	Gene	toxicity|compound|START_ENTITY END_ENTITY|nmod|toxicity	Role of Cdk5-mediated phosphorylation of Prx2 in MPTP toxicity and Parkinson 's _ disease .
14729251	0	MPTP	91,95	TorsinA	0,7	MPTP	TorsinA	MESH:D015632	30931(Tax:10090)	Chemical	Gene	upregulated|nmod|START_ENTITY upregulated|nsubjpass|END_ENTITY	TorsinA , the gene linked to early-onset dystonia , is upregulated by the dopaminergic toxin MPTP in mice .
8965654	0	MPTP	15,19	calbindin-D28k	30,44	MPTP	calbindin-D28k	MESH:D015632	12307(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|amod|END_ENTITY	The neurotoxin MPTP increases calbindin-D28k levels in mouse midbrain dopaminergic neurons .
2785364	0	MPTP	31,35	cytochrome_P-450	91,107	MPTP	cytochrome P-450	MESH:D015632	4051	Chemical	Gene	START_ENTITY|nmod|system system|amod|END_ENTITY	Studies on the interactions of MPTP -LRB- 1-methyl-4-phenyl-1 ,2,3,6 - tetrahydropyridine -RRB- with the cytochrome_P-450 enzyme system -- clues to a possible aetiological factor in Parkinson 's _ disease .
10224310	0	MPTP	110,114	glial_cell_line-derived_neurotrophic_factor	14,57	MPTP	glial cell line-derived neurotrophic factor	MESH:D015632	14573(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of glial_cell_line-derived_neurotrophic_factor and its mRNA in the nigrostriatal pathway following MPTP treatment .
15910760	9	MPTP	1313,1317	mice	1382,1386	MPTP	IL-6	MESH:D015632	16193(Tax:10090)	Chemical	Gene	induced|nsubj|START_ENTITY induced|nmod|END_ENTITY	In left-pawed mice , MPTP induced a higher decrease of DA/DOPAC ratio than in right-pawed mice .
1641061	0	MPTP	31,35	monoamine_oxidase-B	79,98	MPTP	monoamine oxidase-B	MESH:D015632	4129	Chemical	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of the neurotoxin MPTP and its demethylated derivative -LRB- PTP -RRB- with monoamine_oxidase-B .
11090954	0	MPTP	22,26	monoamine_oxidase_B	44,63	MPTP	monoamine oxidase B	MESH:D015632	4129	Chemical	Gene	START_ENTITY|appos|substrate substrate|nmod|END_ENTITY	Cell death induced by MPTP , a substrate for monoamine_oxidase_B .
10817541	0	MP_3022	50,57	5-HT1A	63,69	MP 3022	5-HT1A	MESH:C088974	24473(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Some pharmacological properties of new analogs of MP_3022 , the 5-HT1A receptor antagonist .
2310417	0	MR889	67,72	leukocyte_elastase	45,63	MR889	leukocyte elastase	MESH:C062051	1991	Chemical	Gene	mechanism|nmod|START_ENTITY mechanism|nmod|END_ENTITY	The kinetic mechanism of inhibition of human leukocyte_elastase by MR889 , a new cyclic thiolic compound .
12871312	0	MRS2179	83,90	P2Y1_receptor	94,107	MRS2179	P2Y1 receptor	MESH:C111914	18441(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Inhibition of localized thrombosis in P2Y1-deficient mice and rodents treated with MRS2179 , a P2Y1_receptor antagonist .
19356737	0	MRS_2179	89,97	P2_purinoceptor	101,116	MRS 2179	P2 purinoceptor	MESH:C111914	5031	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	The NANC relaxation of the human ileal longitudinal and circular muscles is inhibited by MRS_2179 , a P2_purinoceptor antagonist .
8689231	0	MS-271	0,6	myosin_light_chain_kinase	50,75	MS-271	myosin light chain kinase	MESH:C100562	396445(Tax:9031)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	MS-271 , a novel inhibitor of calmodulin-activated myosin_light_chain_kinase from Streptomyces sp .
8689232	0	MS-271	0,6	myosin_light_chain_kinase	50,75	MS-271	myosin light chain kinase	MESH:C100562	4638	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	MS-271 , a novel inhibitor of calmodulin-activated myosin_light_chain_kinase from Streptomyces sp .
18394702	0	MS-275	0,6	FLT3	101,105	MS-275	FLT3	MESH:C118739	2322	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|degradation degradation|nmod|END_ENTITY	MS-275 , a novel histone deacetylase inhibitor with selectivity against HDAC1 , induces degradation of FLT3 via inhibition of chaperone function of heat_shock_protein_90 in AML cells .
26122536	0	MS-275	72,78	TRAIL	18,23	MS-275	TRAIL	MESH:C118739	8743	Chemical	Gene	resistance|nmod|START_ENTITY resistance|amod|END_ENTITY	The overriding of TRAIL resistance by the histone deacetylase inhibitor MS-275 involves c-myc up-regulation in cutaneous , uveal , and mucosal_melanoma .
11902904	0	MS-325	19,25	albumin	43,50	MS-325	albumin	MESH:C109932	213	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	The interaction of MS-325 with human serum albumin and its effect on proton relaxation rates .
7592060	0	MS-444	0,6	myosin_light_chain_kinase	27,52	MS-444	myosin light chain kinase	MESH:C096620	4638	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	MS-444 , a new inhibitor of myosin_light_chain_kinase from Micromonospora sp .
7592061	0	MS-444	27,33	myosin_light_chain_kinase	41,66	MS-444	myosin light chain kinase	MESH:C096620	4638	Chemical	Gene	determination|nmod|START_ENTITY determination|dep|inhibitor inhibitor|compound|END_ENTITY	Structure determination of MS-444 ; a new myosin_light_chain_kinase inhibitor .
10639370	0	MS-8209	11,18	tumor_necrosis_factor_alpha	53,80	MS-8209	tumor necrosis factor alpha	MESH:C074660	7124	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|synthesis synthesis|compound|END_ENTITY	Effects of MS-8209 , an amphotericin_B derivative , on tumor_necrosis_factor_alpha synthesis and human_immunodeficiency_virus replication in macrophages .
22266862	4	MS275	772,777	cFLIP	804,809	MS275	TRAIL	MESH:C118739	8743	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|nmod|END_ENTITY	Monitoring a panel of apoptosis-regulatory proteins revealed that MS275 reduces the expression of cFLIP -LRB- L -RRB- and cFLIP -LRB- S -RRB- .
26341629	4	MSA	762,765	ESCC	769,773	MSA	Nrf2	null	4780	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Previous studies demonstrated that the Kelch-like_ECH-associated_protein_1 -LRB- Keap1 -RRB- / Nuclear_factor_E2-related_factor_2 -LRB- Nrf2 -RRB- system plays a critical role in cancer prevention , but little is known about its association with MSA in ESCC cells .
6312718	0	MSA	47,50	multiplication-stimulating_activity	10,45	MSA	multiplication-stimulating activity	null	24483(Tax:10116)	Chemical	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of multiplication-stimulating_activity -LRB- MSA -RRB- on the cyclic_AMP level and proteoglycan synthesis in cultured chondrocytes .
26621632	0	MSG	120,123	TNF-a	96,101	MSG	TNF-a	CHEBI:64243	24835(Tax:10116)	Chemical	Gene	concentrations|nmod|START_ENTITY concentrations|amod|END_ENTITY	Taurine supplementation regulates Ik-Ba protein expression in adipose tissue and serum IL-4 and TNF-a concentrations in MSG obesity .
20075852	0	MSI-1436	38,46	PTP1B	14,19	MSI-1436	PTP1B	MESH:C441128	19246(Tax:10090)	Chemical	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of PTP1B by trodusquemine -LRB- MSI-1436 -RRB- causes fat-specific weight_loss in diet-induced obese mice .
23071812	0	MSM	0,3	GH	13,15	MSM	GH	null	81668(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|signaling signaling|compound|END_ENTITY	MSM enhances GH signaling via the Jak2/STAT5b pathway in osteoblast-like cells and osteoblast differentiation through the activation of STAT5b in MSCs .
23071812	0	MSM	0,3	STAT5b	136,142	MSM	STAT5b	null	25126(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|activation activation|nmod|END_ENTITY	MSM enhances GH signaling via the Jak2/STAT5b pathway in osteoblast-like cells and osteoblast differentiation through the activation of STAT5b in MSCs .
21781853	0	MTBE	84,88	Hsp60	14,19	MTBE	Hsp60	MESH:C043243	3329	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of Hsp60 , a stress protein , in human nasal septa cells after exposure to MTBE .
16040106	0	MTEP	40,44	mGluR5	76,82	MTEP	mGluR5	null	14805(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Potential antidepressant-like effect of MTEP , a potent and highly selective mGluR5 antagonist .
25043733	0	MTEP	52,56	mGluR5	34,40	MTEP	mGluR5	null	14805(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|antagonist antagonist|amod|END_ENTITY	Antidepressant-like effect of the mGluR5 antagonist MTEP in an astroglial_degeneration_model_of_depression .
24631968	0	MTEP	101,105	mTOR	18,22	MTEP	mTOR	null	21977(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Activation Activation|nmod|END_ENTITY	Activation of the mTOR signaling pathway in the antidepressant-like activity of the mGlu5 antagonist MTEP and the mGlu7 agonist AMN082 in the FST in rats .
9698520	0	MTP	10,13	TNF-alpha	17,26	MTP	TNF-alpha	null	24835(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of MTP on TNF-alpha in perfused rat liver after bacteremia and ischemia/reperfusion .
16278838	0	MTPA	4,8	Rh2	0,3	MTPA	Rh2	null	6005	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	Rh2 -LSB- MTPA -RSB- 4 , a dirhodium complex as NMR auxiliary for chiral recognition .
9793644	0	MTT	13,16	glutathione_S-transferase	20,45	MTT	glutathione S-transferase	CHEBI:53233	54486(Tax:10090)	Chemical	Gene	Reduction|nmod|START_ENTITY Reduction|nmod|END_ENTITY	Reduction of MTT by glutathione_S-transferase .
23622764	0	MTX	15,18	CD147	0,5	MTX	CD147	CHEBI:44185	682	Chemical	Gene	resistance|compound|START_ENTITY promotes|dobj|resistance promotes|nsubj|END_ENTITY	CD147 promotes MTX resistance by immune cells through up-regulating ABCG2 expression and function .
2837988	0	MTX	58,61	thymidylate_synthetase	13,35	MTX	thymidylate synthetase	CHEBI:44185	7298	Chemical	Gene	dose|nmod|START_ENTITY END_ENTITY|nmod|dose	-LSB- The role of thymidylate_synthetase in sequential dose of MTX and 5-FU in the advanced scirrhous type gastric_cancer -RSB- .
21822917	0	MVA-BN	19,25	HER2	28,32	MVA-BN	HER2	null	13866(Tax:10090)	Chemical	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Immunotherapy with MVA-BN - HER2 induces HER-2-specific Th1 immunity and alters the intratumoral balance of effector and regulatory T cells .
15313936	0	MX781	24,29	clusterin	38,47	MX781	clusterin	MESH:C115167	1191	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	The retinoid antagonist MX781 induces clusterin expression in prostate_cancer cells via heat_shock_factor-1_and_activator_protein-1 transcription factors .
12650855	0	MZ-4-71	18,25	GH-RH	0,5	MZ-4-71	GH-RH	MESH:C095215	14601(Tax:10090)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	GH-RH antagonist -LRB- MZ-4-71 -RRB- inhibits VEGF secretion and proliferation of murine endothelial cells .
22041656	0	MZ-5-156	16,24	AMPK	53,57	MZ-5-156	AMPK	MESH:C106656	5563	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	GHRH antagonist MZ-5-156 increases the expression of AMPK in A549 lung_cancer cells .
16909596	2	Ma	336,338	RXR	340,343	Ma	Bax	null	581	Chemical	Gene	START_ENTITY|dep|agonist agonist|compound|END_ENTITY	METHODS : The effects of 3 kinds of retinoids -LRB- 9-cis-RA , at-RA and 13-cis-RA -RRB- , of TTNPB -LRB- RAR agonist -RRB- and of Methoprene_acid -LRB- Ma , RXR agonist -RRB- on apoptosis of A375 cells were studied by detecting the expression of Bcl-2 / Bax and by using .
10021940	0	Macrocyclic_hexapeptide	0,23	PAR-1	60,65	Macrocyclic hexapeptide	PAR-1	null	2149	Chemical	Gene	analogues|amod|START_ENTITY analogues|appos|END_ENTITY	Macrocyclic_hexapeptide analogues of the thrombin receptor -LRB- PAR-1 -RRB- activation motif SFLLRN .
17935989	0	Macrocyclic_ureas	0,17	Chk1	42,46	Macrocyclic ureas	Chk1	null	1111	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Macrocyclic_ureas as potent and selective Chk1 inhibitors : an improved synthesis , kinome profiling , structure-activity relationships , and preliminary pharmacokinetics .
17061983	0	Macrolides	0,10	IL8	32,35	Macrolides	IL8	MESH:D018942	3576	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|END_ENTITY	Macrolides inhibit IL17-induced IL8 and 8-isoprostane release from human airway smooth muscle cells .
17268065	0	Macrostemonoside_A	0,18	visfatin	28,36	Macrostemonoside A	visfatin	MESH:C080645	59027(Tax:10090)	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|compound|END_ENTITY	Macrostemonoside_A promotes visfatin expression in 3T3-L1 cells .
20381648	0	Madecassoside	0,13	TNF-alpha	37,46	Madecassoside	TNF-alpha	MESH:C093443	24835(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|production production|amod|END_ENTITY	Madecassoside suppresses LPS-induced TNF-alpha production in cardiomyocytes through inhibition of ERK , p38 , and NF-kappaB activity .
2973151	0	Mafenide	0,8	plasmin	31,38	Mafenide	plasmin	MESH:D008272	5340	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Mafenide -LRB- Sulfamylon -RRB- inhibits plasmin fibrinolytic activity .
25772503	0	Magnesium	0,9	AtMRS2-10	46,55	Magnesium	AtMRS2-10	MESH:D008274	844430(Tax:3702)	Chemical	Gene	uptake|amod|START_ENTITY uptake|amod|END_ENTITY	Magnesium uptake of Arabidopsis transporters , AtMRS2-10 and AtMRS2-11 , expressed in Escherichia_coli mutants : Complementation and growth inhibition by aluminum .
26417155	0	Magnesium	21,30	Insulin	47,54	Magnesium	Insulin	MESH:D008274	3630	Chemical	Gene	Deficiency|compound|START_ENTITY Deficiency|nmod|Resistance Resistance|compound|END_ENTITY	Association of Serum Magnesium Deficiency with Insulin Resistance in Type_2_Diabetes_Mellitus .
11850416	0	Magnesium	0,9	alpha-synuclein	63,78	Magnesium	alpha-synuclein	MESH:D008274	6622	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|aggregation aggregation|nmod|END_ENTITY	Magnesium inhibits spontaneous and iron-induced aggregation of alpha-synuclein .
15617878	0	Magnesium	0,9	insulin	62,69	Magnesium	insulin	MESH:D008274	3630	Chemical	Gene	mediate|nsubj|START_ENTITY mediate|dobj|impact impact|nmod|grains grains|nmod|sensitivity sensitivity|compound|END_ENTITY	Magnesium may mediate the favorable impact of whole grains on insulin sensitivity by acting as a mild calcium antagonist .
17229895	0	Magnesium	0,9	insulin	40,47	Magnesium	insulin	MESH:D008274	3630	Chemical	Gene	intake|compound|START_ENTITY related|nsubjpass|intake related|nmod|homeostasis homeostasis|compound|END_ENTITY	Magnesium intake is related to improved insulin homeostasis in the framingham offspring cohort .
23758216	0	Magnesium	0,9	insulin	75,82	Magnesium	insulin	MESH:D008274	3630	Chemical	Gene	decreases|amod|START_ENTITY Type|nsubj|decreases Type|nmod|improvement improvement|nmod|resistance resistance|compound|END_ENTITY	Magnesium intake decreases Type 2 diabetes risk through the improvement of insulin resistance and inflammation : the Hisayama Study .
8861135	0	Magnesium	0,9	insulin	65,72	Magnesium	insulin	MESH:D008274	3630	Chemical	Gene	vivo|compound|START_ENTITY vivo|nmod|dose dose|nmod|END_ENTITY	Magnesium transport induced ex vivo by a pharmacological dose of insulin is impaired in non-insulin-dependent_diabetes_mellitus .
25006251	0	Magnesium	0,9	myosin	53,59	Magnesium	myosin	MESH:D008274	79784	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|binding binding|nmod|motors motors|compound|END_ENTITY	Magnesium modulates actin binding and ADP release in myosin motors .
15579901	0	Magnesium	0,9	myosin_V	42,50	Magnesium	myosin V	MESH:D008274	4644	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Magnesium regulates ADP dissociation from myosin_V .
1300331	0	Magnesium	0,9	parathyroid_hormone	43,62	Magnesium	parathyroid hormone	MESH:D008274	24694(Tax:10116)	Chemical	Gene	deficiency|amod|START_ENTITY enhances|nsubj|deficiency enhances|dobj|secretion secretion|nmod|END_ENTITY	Magnesium deficiency enhances secretion of parathyroid_hormone in normal and 5/6-nephrectomized uremic rats .
24103811	0	Magnesium	0,9	parathyroid_hormone	20,39	Magnesium	parathyroid hormone	MESH:D008274	24694(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|secretion secretion|amod|END_ENTITY	Magnesium modulates parathyroid_hormone secretion and upregulates parathyroid receptor expression at moderately low calcium concentration .
6276138	0	Magnesium	0,9	parathyroid_hormone	24,43	Magnesium	parathyroid hormone	MESH:D008274	24694(Tax:10116)	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|secretion secretion|amod|END_ENTITY	Magnesium promotes both parathyroid_hormone secretion and adenosine_3 ' ,5 ' - monophosphate production in rat parathyroid tissues and reverses the inhibitory effects of calcium on adenylate cyclase .
9675754	0	Magnesium	0,9	parathyroid_hormone	75,94	Magnesium	parathyroid hormone	MESH:D008274	5741	Chemical	Gene	deficit|amod|START_ENTITY deficit|dep|role role|nmod|resistance resistance|compound|END_ENTITY	Magnesium deficit in major burns : role in hypoparathyroidism and end-organ parathyroid_hormone resistance .
25691139	0	Magnesium_Isoglycyrrhizinate	30,58	Phospholipase_A2	81,97	Magnesium Isoglycyrrhizinate	Phospholipase A2	MESH:C521270	151056	Chemical	Gene	Activity|nmod|START_ENTITY Activity|nmod|END_ENTITY	Anti-inflammatory Activity of Magnesium_Isoglycyrrhizinate Through Inhibition of Phospholipase_A2 / Arachidonic_Acid Pathway .
26604644	0	Magnesium_isoglycyrrhizinate	0,28	STAT3	68,73	Magnesium isoglycyrrhizinate	STAT3	MESH:C521270	25125(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Magnesium_isoglycyrrhizinate inhibits inflammatory response through STAT3 pathway to protect remnant liver function .
22487382	0	Magnesium_sulfate	0,17	high_mobility_group_box_1	44,69	Magnesium sulfate	high mobility group box 1	MESH:D008278	3146	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|nmod|END_ENTITY	Magnesium_sulfate inhibits the secretion of high_mobility_group_box_1 from lipopolysaccharide-activated RAW264 .7 macrophages in vitro .
21757288	0	Magnolol	0,8	HER2	24,28	Magnolol	HER2	MESH:C005498	2064	Chemical	Gene	down-regulates|amod|START_ENTITY END_ENTITY|nsubj|down-regulates	Magnolol down-regulates HER2 gene expression , leading to inhibition of HER2-mediated metastatic potential in ovarian_cancer cells .
17240450	0	Magnolol	0,8	NF-kappaB	20,29	Magnolol	NF-kappaB	MESH:C005498	4790	Chemical	Gene	suppresses|amod|START_ENTITY END_ENTITY|nsubj|suppresses	Magnolol suppresses NF-kappaB activation and NF-kappaB regulated gene expression through inhibition of IkappaB kinase activation .
24052409	0	Mahanine	0,8	PTEN	100,104	Mahanine	PTEN	MESH:C465290	5728	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|activation activation|nmod|END_ENTITY	Mahanine synergistically enhances cytotoxicity of 5-fluorouracil through ROS-mediated activation of PTEN and p53/p73 in colon_carcinoma .
17698033	0	Mahanine	0,8	RASSF1A	67,74	Mahanine	RASSF1A	MESH:C465290	11186	Chemical	Gene	reverses|nsubj|START_ENTITY reverses|dobj|END_ENTITY	Mahanine reverses an epigenetically silenced tumor suppressor gene RASSF1A in human prostate_cancer cells .
24001151	0	Mahanine	0,8	RASSF1A	18,25	Mahanine	RASSF1A	MESH:C465290	11186	Chemical	Gene	restores|amod|START_ENTITY END_ENTITY|nsubj|restores	Mahanine restores RASSF1A expression by down-regulating DNMT1 and DNMT3B in prostate_cancer cells .
21398611	0	Mal	0,3	CREB	39,43	Mal	CREB	CHEBI:25121	12912(Tax:10090)	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|nmod|END_ENTITY	Mal mediates TLR-induced activation of CREB and expression of IL-10 .
25077631	0	Mal	45,48	heme_oxygenase-1	85,101	Mal	heme oxygenase-1	CHEBI:25121	3162	Chemical	Gene	START_ENTITY|nmod|induction induction|nmod|END_ENTITY	Macrophage-activating lipopeptide-2 requires Mal and PI3K for efficient induction of heme_oxygenase-1 .
22511233	0	Malabaricone_C	0,14	heme_oxygenase-1	116,132	Malabaricone C	heme oxygenase-1	MESH:C071787	24451(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|induction induction|nmod|END_ENTITY	Malabaricone_C inhibits PDGF-induced proliferation and migration of aortic smooth muscle cells through induction of heme_oxygenase-1 .
16661284	0	Malate	75,81	Phosphoenolpyruvate_Carboxylase	40,71	Malate	Phosphoenolpyruvate Carboxylase	MESH:C030298	5105	Chemical	Gene	Changes|acl|START_ENTITY Changes|nmod|Sensitivity Sensitivity|nmod|END_ENTITY	Day/Night Changes in the Sensitivity of Phosphoenolpyruvate_Carboxylase to Malate during Crassulacean_Acid Metabolism .
16665178	0	Malate	0,6	phosphoenolpyruvate_carboxylase	21,52	Malate	phosphoenolpyruvate carboxylase	MESH:C030298	5105	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Malate inhibition of phosphoenolpyruvate_carboxylase from crassula .
17364237	0	Malathion	0,9	acetylcholinesterase	75,95	Malathion	acetylcholinesterase	MESH:D008294	43	Chemical	Gene	carbofuran|compound|START_ENTITY sindanus|compound|carbofuran venom|nsubj|sindanus venom|dobj|butyrylcholinesterase butyrylcholinesterase|compound|END_ENTITY	Malathion , carbofuran and paraquat inhibit Bungarus sindanus -LRB- krait -RRB- venom acetylcholinesterase and human serum butyrylcholinesterase in vitro .
6701915	0	Malathion	0,9	acetylcholinesterase	42,62	Malathion	acetylcholinesterase	MESH:D008294	114549(Tax:7955)	Chemical	Gene	toxicity|compound|START_ENTITY toxicity|nmod|inhibition inhibition|nmod|Brachydanio_rerio Brachydanio_rerio|amod|END_ENTITY	Malathion toxicity : in vivo inhibition of acetylcholinesterase in the fish Brachydanio_rerio -LRB- Cyprinidae -RRB- .
21130747	0	Malondialdehyde	0,15	ALDH2	91,96	Malondialdehyde	ALDH2	MESH:D008315	24188(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|translocation translocation|nmod|END_ENTITY	Malondialdehyde inhibits an AMPK-mediated nuclear translocation and repression activity of ALDH2 in transcription .
26305464	0	Malondialdehyde	48,63	IL-17E	72,78	Malondialdehyde	IL-17E	MESH:D008315	64806	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	The Advanced Lipoxidation end Product Precursor Malondialdehyde Induces IL-17E Expression and Skews Lymphocytes to the th17 Subset .
12623287	0	Malondialdehyde	0,15	cartilage_collagen	29,47	Malondialdehyde	cartilage collagen	MESH:D008315	1280	Chemical	Gene	oxidation|amod|START_ENTITY oxidation|nmod|END_ENTITY	Malondialdehyde oxidation of cartilage_collagen by chondrocytes .
17523133	0	Malondialdehyde	0,15	myelin_oligodendrocyte_glycoprotein	32,67	Malondialdehyde	myelin oligodendrocyte glycoprotein	MESH:D008315	17441(Tax:10090)	Chemical	Gene	modification|amod|START_ENTITY modification|nmod|END_ENTITY	Malondialdehyde modification of myelin_oligodendrocyte_glycoprotein leads to increased immunogenicity and encephalitogenicity .
8185594	0	Malotilate	0,10	CYP2E1	43,49	Malotilate	CYP2E1	MESH:C024808	25086(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|nummod|END_ENTITY	Malotilate , a hepatoprotectant , suppresses CYP2E1 expression in rats .
26284970	0	Manganese	45,54	Alpha-Synuclein	0,15	Manganese	Alpha-Synuclein	MESH:D008345	6622	Chemical	Gene	Levels|nmod|START_ENTITY Levels|compound|END_ENTITY	Alpha-Synuclein Regulates Neuronal Levels of Manganese and Calcium .
26284970	0	Manganese	45,54	Alpha-Synuclein	0,15	Manganese	Alpha-Synuclein	MESH:D008345	6622	Chemical	Gene	Levels|nmod|START_ENTITY Levels|compound|END_ENTITY	Alpha-Synuclein Regulates Neuronal Levels of Manganese and Calcium .
10465100	0	Manganese	0,9	MnSOD	58,63	Manganese	MnSOD	MESH:D008345	20656(Tax:10090)	Chemical	Gene	correction|amod|START_ENTITY correction|appos|END_ENTITY	Manganese -LSB- correction of Magnesium -RSB- superoxide dismutase -LRB- MnSOD -RRB- plasmid/liposome pulmonary radioprotective gene therapy : modulation of irradiation-induced mRNA for IL-I , TNF-alpha , and TGF-beta correlates with delay of organizing_alveolitis / fibrosis .
21671088	0	Manganese	0,9	MnSOD	63,68	Manganese	MnSOD	MESH:D008345	6648	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|appos|END_ENTITY	Manganese regulates manganese-containing_superoxide_dismutase -LRB- MnSOD -RRB- expression in the primary broiler_myocardial_cells .
23357421	0	Manganese	0,9	SLC30A10	68,76	Manganese	SLC30A10	MESH:D008345	55532	Chemical	Gene	efflux|amod|START_ENTITY efflux|dep|insights insights|nmod|mutations mutations|compound|END_ENTITY	Manganese efflux in Parkinsonism : insights from newly characterized SLC30A10 mutations .
26628504	0	Manganese	78,87	SLC30A10	43,51	Manganese	SLC30A10	MESH:D008345	55532	Chemical	Gene	Associated|nmod|START_ENTITY Associated|nsubj|Polymorphisms Polymorphisms|nmod|END_ENTITY	Common Polymorphisms in the Solute Carrier SLC30A10 are Associated With Blood Manganese and Neurological Function .
23131343	0	Manganese	0,9	TRPC3	94,99	Manganese	TRPC3	MESH:D008345	7222	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Manganese inhibits ATP-induced calcium entry through the transient receptor potential channel TRPC3 in astrocytes .
22975163	0	Manganese	0,9	caspase-3	20,29	Manganese	caspase-3	MESH:D008345	25402(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	Manganese regulates caspase-3 gene promoter activity by inducing Sp1 phosphorylation in PC12 cells .
21783617	0	Manganese	0,9	dopamine_transporter	97,117	Manganese	dopamine transporter	MESH:D008345	13162(Tax:10090)	Chemical	Gene	accumulation|amod|START_ENTITY dependent|nsubj|accumulation dependent|nmod|END_ENTITY	Manganese accumulation in striatum of mice exposed to toxic doses is dependent upon a functional dopamine_transporter .
16417967	0	Manganese	0,9	iNOS	51,55	Manganese	iNOS	MESH:D008345	18126(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|appos|END_ENTITY	Manganese induces inducible_nitric_oxide_synthase -LRB- iNOS -RRB- expression via activation of both MAP kinase and PI3K/Akt pathways in BV2 microglial cells .
16417967	0	Manganese	0,9	inducible_nitric_oxide_synthase	18,49	Manganese	inducible nitric oxide synthase	MESH:D008345	18126(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Manganese induces inducible_nitric_oxide_synthase -LRB- iNOS -RRB- expression via activation of both MAP kinase and PI3K/Akt pathways in BV2 microglial cells .
17469137	0	Manganese	0,9	iron_regulatory_protein_2	44,69	Manganese	iron regulatory protein 2	MESH:D008345	3658	Chemical	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Manganese targets m-aconitase and activates iron_regulatory_protein_2 in AF5 GABAergic cells .
21671088	0	Manganese	0,9	manganese-containing_superoxide_dismutase	20,61	Manganese	manganese-containing superoxide dismutase	MESH:D008345	6648	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Manganese regulates manganese-containing_superoxide_dismutase -LRB- MnSOD -RRB- expression in the primary broiler_myocardial_cells .
22542671	0	Manganese	0,9	p21	18,21	Manganese	p21	MESH:D008345	24525(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Manganese induces p21 expression in PC12 cells at the transcriptional level .
18332141	0	Manganese	0,9	prion_protein	25,38	Manganese	prion protein	MESH:D008345	19122(Tax:10090)	Chemical	Gene	START_ENTITY|xcomp|binding binding|nmod|END_ENTITY	Manganese binding to the prion_protein .
15851472	0	Manganese	0,9	superoxide_dismutase_2	24,46	Manganese	superoxide dismutase 2	MESH:D008345	856399(Tax:4932)	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Manganese activation of superoxide_dismutase_2 in the mitochondria of Saccharomyces_cerevisiae .
26616112	0	Manganese_superoxide	0,20	MnSOD	32,37	Manganese superoxide	MnSOD	null	6648	Chemical	Gene	dismutase|amod|START_ENTITY dismutase|appos|END_ENTITY	Manganese_superoxide dismutase -LRB- MnSOD -RRB- is a malignant astrocytoma specific biomarker and associated with adverse prognosis in p53 expressing glioblastoma .
26396668	0	Mangiferin	0,10	CIA	22,25	Mangiferin	CIA	MESH:C013592	228869(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	Mangiferin suppresses CIA by suppressing the expression of TNF-a , IL-6 , IL-1b , and RANKL through inhibiting the activation of NF-kB and ERK1/2 .
25216336	0	Mangiferin	0,10	IL-1b	69,74	Mangiferin	IL-1b	MESH:C013592	100008990(Tax:9986)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|nmod|END_ENTITY	Mangiferin reduces the inhibition of chondrogenic differentiation by IL-1b in mesenchymal stem cells from subchondral bone and targets multiple aspects of the Smad and SOX9 pathways .
25901555	0	Mangiferin	0,10	MMP-9	112,117	Mangiferin	MMP-9	MESH:C013592	4318	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|induction induction|nmod|microRNA-15b microRNA-15b|nmod|expression expression|compound|END_ENTITY	Mangiferin regulates proliferation and apoptosis in glioma cells by induction of microRNA-15b and inhibition of MMP-9 expression .
24095822	0	Mangiferin	0,10	MPTP	22,26	Mangiferin	MPTP	MESH:C013592	19255(Tax:10090)	Chemical	Gene	attenuates|compound|START_ENTITY END_ENTITY|nsubj|attenuates	Mangiferin attenuates MPTP induced dopaminergic neurodegeneration and improves motor_impairment , redox balance and Bcl-2 / Bax expression in experimental Parkinson 's _ disease mice .
25499441	0	Mangiferin	0,10	NLRP3	92,97	Mangiferin	NLRP3	MESH:C013592	114548	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|compound|END_ENTITY	Mangiferin inhibits endoplasmic reticulum stress-associated thioredoxin-interacting_protein / NLRP3 inflammasome activation with regulation of AMPK in endothelial cells .
18621015	0	Mangiferin	0,10	cyclooxygenase-2	20,36	Mangiferin	cyclooxygenase-2	MESH:C013592	29527(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Mangiferin inhibits cyclooxygenase-2 expression and prostaglandin_E2 production in activated rat microglial cells .
24794713	0	Mangiferin	0,10	interleukin-6	21,34	Mangiferin	interleukin-6	MESH:C013592	16193(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	Mangiferin regulates interleukin-6 and cystathionine-b-synthase in lipopolysaccharide-induced brain_injury .
25499441	0	Mangiferin	0,10	thioredoxin-interacting_protein	60,91	Mangiferin	thioredoxin-interacting protein	MESH:C013592	10628	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	Mangiferin inhibits endoplasmic reticulum stress-associated thioredoxin-interacting_protein / NLRP3 inflammasome activation with regulation of AMPK in endothelial cells .
10319160	0	Mannich_bases	13,26	A10	45,48	Mannich bases	A10	MESH:D008352	28870	Chemical	Gene	Synthesis|nmod|START_ENTITY Synthesis|nmod|END_ENTITY	Synthesis of Mannich_bases of antineoplaston A10 and their antitumor activity .
26116388	0	Mannich_bases	64,77	Hsp90	81,86	Mannich bases	Hsp90	MESH:D008352	3320	Chemical	Gene	evaluation|nmod|START_ENTITY docking|dobj|evaluation docking|nmod|inhibitors inhibitors|amod|END_ENTITY	Molecular docking study , synthesis and biological evaluation of Mannich_bases as Hsp90 inhibitors .
19481941	0	Mannich_bases	95,108	dopamine_D4_receptor	22,42	Mannich bases	dopamine D4 receptor	MESH:D008352	1815	Chemical	Gene	activities|nmod|START_ENTITY activities|amod|END_ENTITY	Design , synthesis and dopamine_D4_receptor binding activities of new N-heteroaromatic 5/6-ring Mannich_bases .
26202986	0	Mannose	94,101	CD206	112,117	Mannose	CD206	MESH:D008358	4360	Chemical	Gene	Receptor|compound|START_ENTITY Receptor|appos|END_ENTITY	y-Tilmanocept , a New Radiopharmaceutical Tracer for Cancer Sentinel Lymph Nodes , Binds to the Mannose Receptor -LRB- CD206 -RRB- .
2158304	0	Mannose	0,7	insulin	71,78	Mannose	insulin	MESH:D008358	3630	Chemical	Gene	inhibit|advmod|START_ENTITY inhibit|dobj|effects effects|nmod|END_ENTITY	Mannose , glucosamine and inositol_monophosphate inhibit the effects of insulin on lipogenesis .
14978085	0	Mannose	0,7	pmel17	44,50	Mannose	pmel17	MESH:D008358	6490	Chemical	Gene	receptor|amod|START_ENTITY receptor|nmod|END_ENTITY	Mannose receptor targeting of tumor antigen pmel17 to human dendritic cells directs anti-melanoma T cell responses via multiple HLA molecules .
18604641	0	Mannose-6-phosphate	0,19	MPR_300	31,38	Mannose-6-phosphate	MPR 300	MESH:C027693	3482	Chemical	Gene	receptors|amod|START_ENTITY receptors|dep|END_ENTITY	Mannose-6-phosphate receptors -LRB- MPR_300 and 46 -RRB- from the highly evolved invertebrate Asterias rubens -LRB- Echinodermate -RRB- : biochemical and functional characterization of MPR_46 protein .
10481255	0	Mannose_6-phosphate	0,19	MPR_300	31,38	Mannose 6-phosphate	MPR 300	MESH:C027693	3482	Chemical	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Mannose_6-phosphate receptors -LRB- MPR_300 and MPR_46 -RRB- from a teleostean fish -LRB- trout -RRB- .
16773463	0	Mannose_6-phosphate	0,19	MPR_300	30,37	Mannose 6-phosphate	MPR 300	MESH:C027693	3482	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Mannose_6-phosphate receptor -LRB- MPR_300 -RRB- proteins from goat and chicken bind human IGF-II .
2974283	0	Mannose_6-phosphate	0,19	insulin-like_growth_factor_II	82,111	Mannose 6-phosphate	insulin-like growth factor II	MESH:C027693	3481	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|affinity affinity|nmod|receptor receptor|nmod|ligands ligands|amod|END_ENTITY	Mannose_6-phosphate increases the affinity of its cation-independent receptor for insulin-like_growth_factor_II by displacing inhibitory endogenous ligands .
2640487	0	Manoalide	1,10	phospholipase_A2	18,34	Manoalide	phospholipase A2	MESH:C045673	406141(Tax:7460)	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	-LSB- Manoalide : a new phospholipase_A2 inhibitor of marine origin with potential immunoregulatory effect -RSB- .
19409983	0	Manumycin	0,9	STAT3	19,24	Manumycin	STAT3	MESH:C054474	6774	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Manumycin inhibits STAT3 , telomerase activity , and growth of glioma cells by elevating intracellular reactive oxygen species generation .
26602157	0	Manumycin_A	0,11	TNF_alpha	68,77	Manumycin A	TNF alpha	MESH:C054474	7124	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|nmod|END_ENTITY	Manumycin_A downregulates release of proinflammatory cytokines from TNF_alpha stimulated human monocytes .
26352011	0	Manumycin_A	0,11	specificity_protein_1	108,129	Manumycin A	specificity protein 1	MESH:C054474	6667	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Manumycin_A from a new Streptomyces strain induces endoplasmic reticulum stress-mediated cell death through specificity_protein_1 signaling in human oral_squamous_cell_carcinoma .
17291488	0	Matrine	0,7	E2F-1	43,48	Matrine	E2F-1	MESH:C034244	1869	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	Matrine upregulates the cell cycle protein E2F-1 and triggers apoptosis via the mitochondrial pathway in K562 cells .
19346587	0	Matrine	0,7	MMP-1	29,34	Matrine	MMP-1	MESH:C034244	4312	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Matrine inhibits PMA-induced MMP-1 expression in human dermal fibroblasts .
23912239	0	Matrine	0,7	PTEN	18,22	Matrine	PTEN	MESH:C034244	5728	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Matrine activates PTEN to induce growth inhibition and apoptosis in V600EBRAF harboring melanoma cells .
26692928	0	Matrine	0,7	ULBP2	31,36	Matrine	ULBP2	MESH:C034244	80328	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Matrine increases NKG2D ligand ULBP2 in K562 cells via inhibiting JAK/STAT3 pathway : a potential mechanism underlying the immunotherapy of matrine in leukemia .
17823871	0	Matrine	0,7	eIF4E	52,57	Matrine	eIF4E	MESH:C034244	1977	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	Matrine inhibits the activity of translation factor eIF4E through dephosphorylation of 4E-BP1 in gastric MKN45 cells .
21409686	0	Matrine	0,7	matrix_metalloproteinase-9	17,43	Matrine	matrix metalloproteinase-9	MESH:C034244	4318	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Matrine inhibits matrix_metalloproteinase-9 expression and invasion of human hepatocellular_carcinoma cells .
4733681	0	McN-A-1293	33,43	histidine_decarboxylase	74,97	McN-A-1293	histidine decarboxylase	MESH:C006150	3067	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	4-imidazolyl-3-amino-2-butanone -LRB- McN-A-1293 -RRB- , a new specific inhibitor of histidine_decarboxylase .
728219	0	McN-A-1293	73,83	histidine_decarboxylase	110,133	McN-A-1293	histidine decarboxylase	MESH:C006150	3067	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Inhibition of gastric acid secretion by 4-imidazolyl-3-amino-2-butanone -LRB- McN-A-1293 -RRB- , a specific inhibitor of histidine_decarboxylase .
736993	0	McN-A-1293	122,132	histidine_decarboxylase	40,63	McN-A-1293	histidine decarboxylase	MESH:C006150	24443(Tax:10116)	Chemical	Gene	inhibitor|dep|START_ENTITY END_ENTITY|nmod|inhibitor	In vitro inhibition of rat hypothalamus histidine_decarboxylase by a specific inhibitor -- 4-imidazolyl-3-amino-2-butanone -LRB- McN-A-1293 -RRB- .
17490689	0	Me-UCH9	62,69	5-lipoxygenase	95,109	Me-UCH9	5-lipoxygenase	MESH:C521001	11689(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Evaluation of the anti-inflammatory and analgesic activity of Me-UCH9 , a dual cyclooxygenase-2 / 5-lipoxygenase inhibitor .
17490689	0	Me-UCH9	62,69	cyclooxygenase-2	78,94	Me-UCH9	cyclooxygenase-2	MESH:C521001	19225(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Evaluation of the anti-inflammatory and analgesic activity of Me-UCH9 , a dual cyclooxygenase-2 / 5-lipoxygenase inhibitor .
26239802	0	Meclizine	0,9	pregnane_X_receptor	13,32	Meclizine	pregnane X receptor	MESH:D008468	8856	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Meclizine , a pregnane_X_receptor agonist , is a direct inhibitor and mechanism-based inactivator of human cytochrome P450 3A .
15635049	0	Meconium	0,8	IL-8	17,21	Meconium	IL-8	null	396880(Tax:9823)	Chemical	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	Meconium induced IL-8 production and intratracheal albumin alleviated lung_injury in newborn pigs .
10328330	0	Meconium	0,8	cyclooxygenase-2	20,36	Meconium	cyclooxygenase-2	null	29527(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Meconium stimulates cyclooxygenase-2 expression in rat lungs .
11385144	0	Meconium	0,8	inducible_NO_synthase	31,52	Meconium	inducible NO synthase	null	24599(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Meconium induces expression of inducible_NO_synthase and activation of NF-kappaB in rat alveolar macrophages .
15301793	0	Meconium	0,8	platelet-activating_factor	18,44	Meconium	platelet-activating factor	null	300795(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|amod|END_ENTITY	Meconium enhances platelet-activating_factor and tumor necrosis factor production by rat alveolar macrophages .
10215037	0	Medrogestone	10,22	17beta-hydroxysteroid_dehydrogenase	26,61	Medrogestone	17beta-hydroxysteroid dehydrogenase	MESH:D008524	51478	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	Effect of Medrogestone on 17beta-hydroxysteroid_dehydrogenase activity in the hormone-dependent MCF-7 and T-47D human breast_cancer cell lines .
16189295	0	Medroxyprogesterone_acetate	0,27	glucocorticoid_receptor	38,61	Medroxyprogesterone acetate	glucocorticoid receptor	MESH:D017258	2908	Chemical	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Medroxyprogesterone_acetate binds the glucocorticoid_receptor to stimulate alpha-ENaC and sgk1 expression in renal collecting duct epithelia .
25202013	0	Medroxyprogesterone_acetate	0,27	glucocorticoid_receptor	133,156	Medroxyprogesterone acetate	glucocorticoid receptor	MESH:D017258	2908	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|line line|nmod|END_ENTITY	Medroxyprogesterone_acetate differentially regulates interleukin -LRB- IL -RRB- -12 and IL-10 in a human ectocervical epithelial cell line in a glucocorticoid_receptor -LRB- GR -RRB- - dependent manner .
11029784	0	Medroxyprogesterone_acetate	0,27	interleukin-6	49,62	Medroxyprogesterone acetate	interleukin-6	MESH:D017258	3569	Chemical	Gene	START_ENTITY|dep|involvement involvement|amod|END_ENTITY	Medroxyprogesterone_acetate and cancer_cachexia : interleukin-6 involvement .
12729473	0	Medroxyprogesterone_acetate	0,27	interleukin-6	51,64	Medroxyprogesterone acetate	interleukin-6	MESH:D017258	3569	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|secretion secretion|nmod|END_ENTITY	Medroxyprogesterone_acetate decreases secretion of interleukin-6 and parathyroid_hormone-related_protein in a new anaplastic thyroid_cancer cell line , KTC-2 .
8941005	0	Medroxyprogesterone_acetate	0,27	interleukin-6	52,65	Medroxyprogesterone acetate	interleukin-6	MESH:D017258	3569	Chemical	Gene	treatment|amod|START_ENTITY reduces|nsubj|treatment reduces|dobj|levels levels|amod|END_ENTITY	Medroxyprogesterone_acetate treatment reduces serum interleukin-6 levels in patients with metastatic breast_carcinoma .
10027341	0	Medroxyprogesterone_acetate	0,27	interleukin_6	37,50	Medroxyprogesterone acetate	interleukin 6	MESH:D017258	3569	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|amod|END_ENTITY	Medroxyprogesterone_acetate inhibits interleukin_6 secretion from KPL-4 human breast_cancer cells both in vitro and in vivo : a possible mechanism of the anticachectic effect .
21607504	0	Medroxyprogesterone_acetate	0,27	pai-1	44,49	Medroxyprogesterone acetate	pai-1	MESH:D017258	5054	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|secretion secretion|amod|END_ENTITY	Medroxyprogesterone_acetate -LRB- mpa -RRB- increases pai-1 secretion from huvec and elevates the plasma-levels of pai-I in-vivo .
21114983	0	Megestrol_acetate	0,17	C/EBPb	83,89	Megestrol acetate	C/EBPb	MESH:D019290	24253(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Megestrol_acetate inhibits the expression of cytoplasmic aromatase through nuclear C/EBPb in reperfusion_injury-induced ischemic rat hippocampus .
22546231	0	Melagatran	0,10	thrombin	21,29	Melagatran	thrombin	MESH:C109573	29251(Tax:10116)	Chemical	Gene	inhibitor|advmod|START_ENTITY inhibitor|nsubj|END_ENTITY	Melagatran , a direct thrombin inhibitor , but not edoxaban , a direct factor Xa inhibitor , nor heparin aggravates tissue factor-induced hypercoagulation in rats .
9869178	0	Melagatran	0,10	thrombin	35,43	Melagatran	thrombin	MESH:C109573	100144442(Tax:9823)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Melagatran , a low molecular weight thrombin inhibitor , counteracts endotoxin-induced haemodynamic_and_renal_dysfunctions in the pig .
9679561	0	Melanin	0,7	glutathione_S-transferase	38,63	Melanin	glutathione S-transferase	MESH:D008543	373156	Chemical	Gene	content|compound|START_ENTITY content|nmod|END_ENTITY	Melanin content and downregulation of glutathione_S-transferase contribute to the action of L-buthionine-S-sulfoximine on human melanoma .
1590783	0	Melanins	0,8	tyrosinase	40,50	Melanins	tyrosinase	MESH:D008543	7299	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Melanins production from enkephalins by tyrosinase .
19005892	0	Melatonin	0,9	ALA-S	46,51	Melatonin	ALA-S	MESH:D008550	65155(Tax:10116)	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|compound|END_ENTITY	Melatonin and environmental lighting regulate ALA-S gene expression and So_porphyrin biosynthesis in the rat harderian gland .
20157392	0	Melatonin	0,9	Akt	18,21	Melatonin	Akt	MESH:D008550	24185(Tax:10116)	Chemical	Gene	Phosphorylation|compound|START_ENTITY Phosphorylation|compound|END_ENTITY	Melatonin Induces Akt Phosphorylation through Melatonin Receptor - and PI3K-Dependent Pathways in Primary Astrocytes .
20157392	0	Melatonin	46,55	Akt	18,21	Melatonin	Akt	MESH:D008550	24185(Tax:10116)	Chemical	Gene	Receptor|compound|START_ENTITY Phosphorylation|nmod|Receptor Phosphorylation|compound|END_ENTITY	Melatonin Induces Akt Phosphorylation through Melatonin Receptor - and PI3K-Dependent Pathways in Primary Astrocytes .
11166706	0	Melatonin	0,9	Arg-vasopressin	19,34	Melatonin	Arg-vasopressin	MESH:D008550	24221(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|amod|END_ENTITY	Melatonin inhibits Arg-vasopressin release via MT -LRB- 2 -RRB- receptor in the suprachiasmatic nucleus-slice culture of rats .
24419931	0	Melatonin	0,9	BCL-xl	38,44	Melatonin	BCL-xl	MESH:D008550	12048(Tax:10090)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	Melatonin modulates the expression of BCL-xl and improve the development of vitrified embryos obtained by IVF in mice .
23701823	0	Melatonin	0,9	BMP-4	76,81	Melatonin	BMP-4	MESH:D008550	12159(Tax:10090)	Chemical	Gene	activation|compound|START_ENTITY suppresses|nsubj|activation suppresses|dobj|production production|nmod|action action|compound|END_ENTITY	Melatonin receptor activation suppresses adrenocorticotropin production via BMP-4 action by pituitary AtT20 cells .
15683462	0	Melatonin	0,9	Bax	45,48	Melatonin	Bax	MESH:D008550	24887(Tax:10116)	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|dobj|expression expression|compound|END_ENTITY	Melatonin prevents hydrogen_peroxide-induced Bax expression in cultured rat astrocytes .
25871298	0	Melatonin	25,34	Brain-Derived_Neurotrophic_Factor	76,109	Melatonin	Brain-Derived Neurotrophic Factor	MESH:D008550	24225(Tax:10116)	Chemical	Gene	Levels|compound|START_ENTITY Levels|nmod|END_ENTITY	Short - but Not Long-Term Melatonin Administration Reduces Central Levels of Brain-Derived_Neurotrophic_Factor in Rats with Inflammatory Pain .
18271676	0	Melatonin	0,9	C-peptide	37,46	Melatonin	C-peptide	MESH:D008550	3630	Chemical	Gene	correlates|nsubj|START_ENTITY correlates|nmod|END_ENTITY	Melatonin negatively correlates with C-peptide after food intake .
12829319	0	Melatonin	0,9	Cry1	18,22	Melatonin	Cry1	MESH:D008550	299691(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Melatonin induces Cry1 expression in the pars tuberalis of the rat .
16635015	0	Melatonin	0,9	ER_alpha	24,32	Melatonin	ER alpha	MESH:D008550	2099	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|compound|END_ENTITY	Melatonin inhibits both ER_alpha activation and breast_cancer cell proliferation induced by a metalloestrogen , cadmium .
1334199	0	Melatonin	0,9	Fos	21,24	Melatonin	Fos	MESH:D008550	314322(Tax:10116)	Chemical	Gene	influences|nsubj|START_ENTITY influences|dobj|expression expression|compound|END_ENTITY	Melatonin influences Fos expression in the rat suprachiasmatic .
23257900	0	Melatonin	0,9	FoxO3a	55,61	Melatonin	FoxO3a	MESH:D008550	2309	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Melatonin induces transcriptional regulation of Bim by FoxO3a in HepG2 cells .
26948666	0	Melatonin	0,9	GHRH	48,52	Melatonin	GHRH	MESH:D008550	419178(Tax:9031)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|compound|END_ENTITY	Melatonin modulates monochromatic light-induced GHRH expression in the hypothalamus and GH secretion in chicks .
25250716	0	Melatonin	0,9	Gaq	100,103	Melatonin	Gaq	MESH:D008550	2776	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Melatonin enhances the human mesenchymal stem cells motility via melatonin receptor 2 coupling with Gaq in skin wound healing .
19552765	0	Melatonin	0,9	HIF-1_alpha	25,36	Melatonin	HIF-1 alpha	MESH:D008550	3091	Chemical	Gene	down-regulates|compound|START_ENTITY END_ENTITY|nsubj|down-regulates	Melatonin down-regulates HIF-1_alpha expression through inhibition of protein translation in prostate_cancer cells .
26339621	0	Melatonin	26,35	Interleukin-1_b	0,15	Melatonin	Interleukin-1 b	MESH:D008550	3553	Chemical	Gene	Secretion|compound|START_ENTITY Secretion|compound|END_ENTITY	Interleukin-1_b Modulates Melatonin Secretion in Ovine Pineal Gland : Ex Vivo Study .
22856547	0	Melatonin	0,9	Kip1	68,72	Melatonin	Kip1	MESH:D008550	1027	Chemical	Gene	up-regulation|compound|START_ENTITY up-regulation|nmod|END_ENTITY	Melatonin MT1 receptor-induced transcriptional up-regulation of p27 -LRB- Kip1 -RRB- in prostate_cancer antiproliferation is mediated via inhibition of constitutively active nuclear factor kappa B -LRB- NF-kB -RRB- : potential implications on prostate_cancer chemoprevention and therapy .
8074686	0	Melatonin	0,9	LDL_receptor	19,31	Melatonin	LDL receptor	MESH:D008550	3949	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	Melatonin inhibits LDL_receptor activity and cholesterol synthesis in freshly isolated human mononuclear leukocytes .
12003644	0	Melatonin	0,9	MAdCAM-1	46,54	Melatonin	MAdCAM-1	MESH:D008550	8174	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|nmod|END_ENTITY	Melatonin reduces TNF-a induced expression of MAdCAM-1 via inhibition of NF-kappaB .
26732239	0	Melatonin	0,9	MMP-9	19,24	Melatonin	MMP-9	MESH:D008550	4318	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|transactivation transactivation|compound|END_ENTITY	Melatonin inhibits MMP-9 transactivation and renal_cell_carcinoma metastasis by suppressing Akt-MAPKs pathway and NF-kB-DNA - binding activity .
22619232	0	Melatonin	0,9	MMP9	32,36	Melatonin	MMP9	MESH:D008550	4318	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Melatonin inhibits IL1b-induced MMP9 expression and activity in human umbilical vein endothelial cells by suppressing NF-kB activation .
12932201	0	Melatonin	0,9	MT1	140,143	Melatonin	MT1	MESH:D008550	644314	Chemical	Gene	slowed|nsubj|START_ENTITY slowed|nmod|patient patient|dep|expressed expressed|dobj|subtype subtype|nummod|END_ENTITY	Melatonin slowed the early biochemical progression of hormone-refractory_prostate_cancer in a patient whose prostate_tumor tissue expressed MT1 receptor subtype .
18621029	0	Melatonin	0,9	MT1	75,78	Melatonin	MT1	MESH:D008550	17748(Tax:10090)	Chemical	Gene	granule|nsubj|START_ENTITY granule|nmod|END_ENTITY	Melatonin signaling in mouse cerebellar granule cells with variable native MT1 and MT2 melatonin receptors .
19261884	0	Melatonin	0,9	MT1	54,57	Melatonin	MT1	MESH:D008550	17748(Tax:10090)	Chemical	Gene	transmits|nsubj|START_ENTITY transmits|nmod|receptor receptor|compound|END_ENTITY	Melatonin transmits photoperiodic signals through the MT1 melatonin receptor .
19706469	0	Melatonin	0,9	MT1	83,86	Melatonin	MT1	MESH:D008550	17748(Tax:10090)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|function function|nmod|retina retina|nmod|receptor receptor|compound|END_ENTITY	Melatonin modulates visual function and cell viability in the mouse retina via the MT1 melatonin receptor .
21718361	0	Melatonin	0,9	MT1	105,108	Melatonin	MT1	MESH:D008550	644314	Chemical	Gene	modulation|compound|START_ENTITY modulation|dep|role role|nmod|receptor receptor|compound|END_ENTITY	Melatonin modulation of intracellular signaling pathways in hepatocarcinoma HepG2 cell line : role of the MT1 receptor .
21757639	0	Melatonin	0,9	MT1	85,88	Melatonin	MT1	MESH:D008550	24567(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|receptors receptors|amod|interaction interaction|nmod|END_ENTITY	Melatonin inhibits cholangiocyte hyperplasia in cholestatic rats by interaction with MT1 but not MT2 melatonin receptors .
22856547	0	Melatonin	0,9	MT1	10,13	Melatonin	MT1	MESH:D008550	644314	Chemical	Gene	up-regulation|compound|START_ENTITY up-regulation|compound|END_ENTITY	Melatonin MT1 receptor-induced transcriptional up-regulation of p27 -LRB- Kip1 -RRB- in prostate_cancer antiproliferation is mediated via inhibition of constitutively active nuclear factor kappa B -LRB- NF-kB -RRB- : potential implications on prostate_cancer chemoprevention and therapy .
22980085	0	Melatonin	0,9	MT1	115,118	Melatonin	MT1	MESH:D008550	539948(Tax:9913)	Chemical	Gene	suppresses|compound|START_ENTITY apoptosis|nsubj|suppresses apoptosis|nmod|cells cells|nmod|receptors receptors|appos|END_ENTITY	Melatonin suppresses apoptosis and stimulates progesterone production by bovine granulosa cells via its receptors -LRB- MT1 and MT2 -RRB- .
23537713	0	Melatonin	0,9	MT1	85,88	Melatonin	MT1	MESH:D008550	17773(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|progression progression|dep|c/caspase c/caspase|dep|loss loss|compound|END_ENTITY	Melatonin inhibits the caspase-1 / cytochrome c/caspase -3 cell death pathway , inhibits MT1 receptor loss and delays disease progression in a mouse model of amyotrophic_lateral_sclerosis .
24768045	0	Melatonin	0,9	MT1	91,94	Melatonin	MT1	MESH:D008550	539948(Tax:9913)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|development development|nmod|cells cells|nmod|END_ENTITY	Melatonin regulates the development and function of bovine Sertoli cells via its receptors MT1 and MT2 .
25514412	0	Melatonin	22,31	MT1	18,21	Melatonin	MT1	MESH:D008550	4499	Chemical	Gene	Receptor|compound|START_ENTITY Receptor|compound|END_ENTITY	Expression of the MT1 Melatonin Receptor in Ovarian_Cancer Cells .
25585597	0	Melatonin	0,9	MT1	79,82	Melatonin	MT1	MESH:D008550	644314	Chemical	Gene	influences|nsubj|START_ENTITY influences|nmod|receptors receptors|amod|pancreatic pancreatic|dep|cells cells|nmod|END_ENTITY	Melatonin influences somatostatin secretion from human pancreatic - cells via MT1 and MT2 receptors .
25638817	0	Melatonin	74,83	MT1	84,87	Melatonin	MT1	MESH:D008550	17748(Tax:10090)	Chemical	Gene	Mice|compound|START_ENTITY Mice|compound|END_ENTITY	Melancholic-Like Behaviors and Circadian Neurobiological Abnormalities in Melatonin MT1 Receptor Knockout Mice .
26514204	0	Melatonin	12,21	MT1	0,3	Melatonin	MT1	MESH:D008550	644314	Chemical	Gene	Receptors|compound|START_ENTITY Receptors|compound|END_ENTITY	MT1 and MT2 Melatonin Receptors : A Therapeutic Perspective .
15522910	0	Melatonin	0,9	MT2	34,37	Melatonin	MT2	MESH:D008550	4502	Chemical	Gene	desensitizes|compound|START_ENTITY endogenous|nsubj|desensitizes endogenous|dobj|receptors receptors|nummod|END_ENTITY	Melatonin desensitizes endogenous MT2 melatonin receptors in the rat suprachiasmatic nucleus : relevance for defining the periods of sensitivity of the mammalian circadian clock to melatonin .
16635021	0	Melatonin	0,9	MT2	134,137	Melatonin	MT2	MESH:D008550	4502	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|advcl|differentiating differentiating|dobj|cells cells|acl|grown grown|nmod|medium medium|nmod|receptors receptors|compound|END_ENTITY	Melatonin enhances alkaline_phosphatase activity in differentiating human adult mesenchymal stem cells grown in osteogenic medium via MT2 melatonin receptors and the MEK/ERK _ -LRB- 1/2 -RRB- signaling cascade .
20544829	0	Melatonin	0,9	MT2	103,106	Melatonin	MT2	MESH:D008550	4502	Chemical	Gene	action|nmod:poss|START_ENTITY associated|nsubjpass|action associated|nmod|up-regulation up-regulation|nmod|receptor receptor|compound|END_ENTITY	Melatonin 's protective action against ischemic neuronal_damage is associated with up-regulation of the MT2 melatonin receptor .
21094224	0	Melatonin	0,9	MT2	100,103	Melatonin	MT2	MESH:D008550	689415(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|channels channels|nmod|rod rod|nmod|cells cells|nmod|receptors receptors|nummod|END_ENTITY	Melatonin inhibits tetraethylammonium-sensitive potassium channels of rod ON type bipolar cells via MT2 receptors in rat retina .
21585522	0	Melatonin	0,9	MT2	134,137	Melatonin	MT2	MESH:D008550	4502	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|expressing expressing|dobj|END_ENTITY	Melatonin inhibits insulin secretion in rat insulinoma b-cells -LRB- INS-1 -RRB- heterologously expressing the human melatonin receptor isoform MT2 .
23519105	0	Melatonin	115,124	MT2	135,138	Melatonin	MT2	MESH:D008550	4502	Chemical	Gene	Receptor|compound|START_ENTITY Receptor|appos|END_ENTITY	Abnormal Skeletal Growth in Adolescent_Idiopathic_Scoliosis Is Associated with Abnormal Quantitative Expression of Melatonin Receptor , MT2 .
23698757	0	Melatonin	74,83	MT2	70,73	Melatonin	MT2	MESH:D008550	4502	Chemical	Gene	Receptors|compound|START_ENTITY Receptors|compound|END_ENTITY	New Radioligands for Describing the Molecular Pharmacology of MT1 and MT2 Melatonin Receptors .
25550330	0	Melatonin	0,9	MT2	107,110	Melatonin	MT2	MESH:D008550	17750(Tax:10090)	Chemical	Gene	Memory_Impairment|compound|START_ENTITY Induced|nsubj|Memory_Impairment Induced|nmod|Receptor Receptor|compound|END_ENTITY	Melatonin Attenuates Memory_Impairment Induced by Klotho Gene Deficiency Via Interactive Signaling Between MT2 Receptor , ERK , and Nrf2-Related Antioxidant Potential .
26334942	0	Melatonin	32,41	MT2	28,31	Melatonin	MT2	MESH:D008550	4502	Chemical	Gene	Full|compound|START_ENTITY Full|compound|END_ENTITY	Highly Potent and Selective MT2 Melatonin Receptor Full Agonists from Conformational Analysis of 1-Benzyl-2-acylaminomethyl-tetrahydroquinolines .
24892818	0	Melatonin	10,19	Mt2	75,78	Melatonin	Mt2	MESH:D008550	4502	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|Involvement Involvement|nmod|Receptor Receptor|compound|END_ENTITY	Effect of Melatonin and Analogues on Corneal Wound Healing : Involvement of Mt2 Melatonin Receptor .
24892818	0	Melatonin	79,88	Mt2	75,78	Melatonin	Mt2	MESH:D008550	4502	Chemical	Gene	Receptor|compound|START_ENTITY Receptor|compound|END_ENTITY	Effect of Melatonin and Analogues on Corneal Wound Healing : Involvement of Mt2 Melatonin Receptor .
22537289	0	Melatonin	0,9	MyD88	61,66	Melatonin	MyD88	MESH:D008550	17874(Tax:10090)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	Melatonin modulates TLR4-mediated inflammatory genes through MyD88 - and TRIF-dependent signaling pathways in lipopolysaccharide-stimulated RAW264 .7 cells .
25655081	0	Melatonin	0,9	MyD88	69,74	Melatonin	MyD88	MESH:D008550	301059(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|nmod|END_ENTITY	Melatonin attenuates the TLR4-mediated inflammatory response through MyD88 - and TRIF-dependent signaling pathways in an in vivo model of ovarian_cancer .
25835505	0	Melatonin	0,9	Myeloperoxidase	19,34	Melatonin	Myeloperoxidase	MESH:D008550	4353	Chemical	Gene	Destruction|compound|START_ENTITY Destruction|compound|END_ENTITY	Melatonin Prevents Myeloperoxidase Heme Destruction and the Generation of Free Iron Mediated by Self-Generated Hypochlorous_Acid .
19552759	0	Melatonin	0,9	NF-kB	88,93	Melatonin	NF-kB	MESH:D008550	309165(Tax:10116)	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|inhibition inhibition|nmod|END_ENTITY	Melatonin protects kidney grafts from ischemia/reperfusion injury through inhibition of NF-kB and apoptosis after experimental kidney transplantation .
11408087	0	Melatonin	0,9	PKC-alpha	20,29	Melatonin	PKC-alpha	MESH:D008550	18750(Tax:10090)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Melatonin activates PKC-alpha but not PKC-epsilon in N1E-115 cells .
19215392	0	Melatonin	17,26	Prolactin	82,91	Melatonin	Prolactin	MESH:D008550	5617	Chemical	Gene	Infusions|compound|START_ENTITY Effects|nmod|Infusions Effects|nmod|Nuclei Nuclei|nmod|Secretions Secretions|compound|END_ENTITY	Effects of Timed Melatonin Infusions and Lesions of the Suprachiasmatic Nuclei on Prolactin and Progesterone Secretions in Pregnant or Pseudopregnant Mink -LRB- Mustela vison -RRB- .
23030129	0	Melatonin	0,9	S100b	30,35	Melatonin	S100b	MESH:D008550	25742(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|levels levels|nmod|END_ENTITY	Melatonin decreases levels of S100b and NF B , increases levels of synaptophysin in a rat model of Alzheimer 's _ disease .
25052362	0	Melatonin	0,9	SIRT1	95,100	Melatonin	SIRT1	MESH:D008550	309757(Tax:10116)	Chemical	Gene	protection|amod|START_ENTITY protection|dep|injury injury|dep|role role|nmod|END_ENTITY	Melatonin receptor-mediated protection against myocardial_ischemia / reperfusion injury : role of SIRT1 .
26607398	0	Melatonin	0,9	SIRT1	106,111	Melatonin	SIRT1	MESH:D008550	93759(Tax:10090)	Chemical	Gene	facilitates|nsubj|START_ENTITY facilitates|xcomp|repair repair|dobj|heart heart|nmod|END_ENTITY	Melatonin facilitates adipose-derived mesenchymal stem cells to repair the murine infarcted heart via the SIRT1 signaling pathway .
26918354	0	Melatonin	0,9	SIRT1	88,93	Melatonin	SIRT1	MESH:D008550	23411	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|death death|nmod|pathway pathway|compound|END_ENTITY	Melatonin protects skin keratinocyte from hydrogen_peroxide-mediated cell death via the SIRT1 pathway .
21062352	0	Melatonin	0,9	Sirt1	19,24	Melatonin	Sirt1	MESH:D008550	23411	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Melatonin , a novel Sirt1 inhibitor , imparts antiproliferative effects against prostate_cancer in vitro in culture and in vivo in TRAMP model .
26921571	0	Melatonin	125,134	Somatostatin	51,63	Melatonin	Somatostatin	MESH:D008550	6750	Chemical	Gene	sulfate|appos|START_ENTITY sulfate|compound|END_ENTITY	Congenital_fibrosarcoma in complete remission with Somatostatin , Bromocriptine , Retinoids , Vitamin_D3 , Vitamin_E , Vitamin_C , Melatonin , Calcium , Chondroitin sulfate associated with low doses of Cyclophosphamide in a 14-year Follow up .
12003644	0	Melatonin	0,9	TNF-a	18,23	Melatonin	TNF-a	MESH:D008550	7124	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|amod|END_ENTITY	Melatonin reduces TNF-a induced expression of MAdCAM-1 via inhibition of NF-kappaB .
18289162	0	Melatonin	0,9	VEGF	38,42	Melatonin	VEGF	MESH:D008550	7422	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	Melatonin modulates the expression of VEGF and HIF-1_alpha induced by CoCl2 in cultured cancer cells .
20825493	7	Melatonin	1211,1220	ZT18	1201,1205	Melatonin	Cry1	MESH:D008550	12952(Tax:10090)	Chemical	Gene	concentration|compound|START_ENTITY concentration|compound|END_ENTITY	Nevertheless , a significant daily variation could be observed under DD , with a small increase at ZT6 and ZT18 h. Melatonin concentration was significantly suppressed by acute light pulse at ZT22 in wild-type mice but not in Cry1 -LRB- - / - -RRB- / Cry2 -LRB- - / - -RRB- mice .
16635021	0	Melatonin	0,9	alkaline_phosphatase	19,39	Melatonin	alkaline phosphatase	MESH:D008550	250	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|amod|END_ENTITY	Melatonin enhances alkaline_phosphatase activity in differentiating human adult mesenchymal stem cells grown in osteogenic medium via MT2 melatonin receptors and the MEK/ERK _ -LRB- 1/2 -RRB- signaling cascade .
15009507	0	Melatonin	0,9	caspase-3	97,106	Melatonin	caspase-3	MESH:D008550	12367(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|nmod|ischemia ischemia|nmod|mice mice|nmod|inhibition inhibition|nmod|END_ENTITY	Melatonin reduces disseminate neuronal_death after mild focal ischemia in mice via inhibition of caspase-3 and is suitable as an add-on treatment to tissue-plasminogen_activator .
21244482	0	Melatonin	0,9	caspase-3	66,75	Melatonin	caspase-3	MESH:D008550	836	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|apoptosis apoptosis|nmod|END_ENTITY	Melatonin promotes puromycin-induced apoptosis with activation of caspase-3 and 5 ' - adenosine_monophosphate-activated kinase-alpha in human leukemia HL-60 cells .
16609073	0	Melatonin	0,9	cyclooxygenase-2	32,48	Melatonin	cyclooxygenase-2	MESH:D008550	19225(Tax:10090)	Chemical	Gene	suppresses|compound|START_ENTITY macrophage|nsubj|suppresses macrophage|dobj|expression expression|amod|END_ENTITY	Melatonin suppresses macrophage cyclooxygenase-2 and inducible_nitric_oxide_synthase expression by inhibiting p52 acetylation and binding .
24628039	0	Melatonin	0,9	endothelin-1	18,30	Melatonin	endothelin-1	MESH:D008550	1906	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|amod|END_ENTITY	Melatonin reduces endothelin-1 expression and secretion in colon_cancer cells through the inactivation of FoxO-1 and NF-kb .
10224229	0	Melatonin	0,9	estrogen_receptor	35,52	Melatonin	estrogen receptor	MESH:D008550	2099	Chemical	Gene	blocks|nsubj|START_ENTITY blocks|dobj|activation activation|nmod|END_ENTITY	Melatonin blocks the activation of estrogen_receptor for DNA binding .
15229223	0	Melatonin	0,9	estrogen_receptor_alpha	47,70	Melatonin	estrogen receptor alpha	MESH:D008550	2099	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Melatonin , an endogenous-specific inhibitor of estrogen_receptor_alpha via calmodulin .
10463946	0	Melatonin	0,9	glucocorticoid_receptor	20,43	Melatonin	glucocorticoid receptor	MESH:D008550	2908	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Melatonin regulates glucocorticoid_receptor : an answer to its antiapoptotic action in thymus .
7714075	0	Melatonin	0,9	gonadotropin-releasing_hormone	89,119	Melatonin	gonadotropin-releasing hormone	MESH:D008550	2796	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|xcomp|END_ENTITY	Melatonin enhances the luteinizing hormone and follicle-stimulating hormone responses to gonadotropin-releasing_hormone in the follicular , but not in the luteal , menstrual phase .
24350898	0	Melatonin	0,9	growth-associated_protein-43	55,83	Melatonin	growth-associated protein-43	MESH:D008550	29423(Tax:10116)	Chemical	Gene	improves|nsubj|START_ENTITY improves|advcl|upregulating upregulating|dobj|END_ENTITY	Melatonin improves neuroplasticity by upregulating the growth-associated_protein-43 -LRB- GAP-43 -RRB- and NMDAR postsynaptic density-95 -LRB- PSD-95 -RRB- proteins in cultured neurons exposed to glutamate excitotoxicity and in rats subjected to transient focal cerebral_ischemia even during a long-term recovery period .
18063680	0	Melatonin	0,9	growth_hormone	36,50	Melatonin	growth hormone	MESH:D008550	2688	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|nmod|END_ENTITY	Melatonin stimulates the release of growth_hormone and prolactin by a possible induction of the expression of frog growth_hormone-releasing_peptide and its related peptide-2 in the amphibian hypothalamus .
21649718	0	Melatonin	0,9	growth_hormone	34,48	Melatonin	growth hormone	MESH:D008550	81668(Tax:10116)	Chemical	Gene	START_ENTITY|dep|physiology physiology|nmod|END_ENTITY	Melatonin , and to a lesser extent growth_hormone , restores colonic smooth muscle physiology in old rats .
8370132	0	Melatonin	0,9	growth_hormone	21,35	Melatonin	growth hormone	MESH:D008550	2688	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|amod|END_ENTITY	Melatonin stimulates growth_hormone secretion through pathways other than the growth_hormone-releasing_hormone .
12628486	0	Melatonin	0,9	hMT1	70,74	Melatonin	hMT1	MESH:D008550	56052	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	Melatonin differentially modulates the expression and function of the hMT1 and hMT2 melatonin receptors upon prolonged withdrawal .
21073519	0	Melatonin	0,9	heme_oxygenase-1	56,72	Melatonin	heme oxygenase-1	MESH:D008550	3162	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Melatonin synergistically increases resveratrol-induced heme_oxygenase-1 expression through the inhibition of ubiquitin-dependent proteasome pathway : a possible role in neuroprotection .
22288898	0	Melatonin	0,9	heme_oxygenase-1	30,46	Melatonin	heme oxygenase-1	MESH:D008550	15368(Tax:10090)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|xcomp|END_ENTITY	Melatonin enhances endogenous heme_oxygenase-1 and represses immune responses to ameliorate experimental murine membranous_nephropathy .
22288937	0	Melatonin	0,9	heme_oxygenase-1	75,91	Melatonin	heme oxygenase-1	MESH:D008550	24451(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|signaling signaling|nmod|toll-like_receptor_4 toll-like_receptor_4|nmod|induction induction|amod|END_ENTITY	Melatonin inhibits type 1 interferon signaling of toll-like_receptor_4 via heme_oxygenase-1 induction in hepatic_ischemia / reperfusion .
25000190	0	Melatonin	0,9	iNOS	72,76	Melatonin	iNOS	MESH:D008550	4843	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|advcl|inhibiting inhibiting|xcomp|signaling signaling|dep|END_ENTITY	Melatonin enhances the anti-tumor effect of fisetin by inhibiting COX-2 / iNOS and NF-kB/p300 signaling pathways .
26735612	0	Melatonin	0,9	interleukin-10	19,33	Melatonin	interleukin-10	MESH:D008550	3586	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Melatonin enhances interleukin-10 expression and suppresses chemotaxis to inhibit inflammation in situ and reduce the severity of experimental_autoimmune_encephalomyelitis .
17286740	0	Melatonin	0,9	interleukin-1_beta	81,99	Melatonin	interleukin-1 beta	MESH:D008550	16176(Tax:10090)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|xcomp|END_ENTITY	Melatonin decreases nitric_oxide production and lipid peroxidation and increases interleukin-1_beta in the brain of mice infected by the Venezuelan_equine_encephalomyelitis_virus .
15572654	0	Melatonin	0,9	leptin	19,25	Melatonin	leptin	MESH:D008550	25608(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	Melatonin enhances leptin expression by rat adipocytes in the presence of insulin .
6993981	0	Melatonin	0,9	luteinizing_hormone-releasing_hormone	58,95	Melatonin	luteinizing hormone-releasing hormone	MESH:D008550	25194(Tax:10116)	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|acl|END_ENTITY	Melatonin inhibition of the in vivo pituitary response to luteinizing_hormone-releasing_hormone in the neonatal rat .
7724042	0	Melatonin	0,9	luteinizing_hormone_releasing_hormone	19,56	Melatonin	luteinizing hormone releasing hormone	MESH:D008550	25194(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|induction induction|amod|END_ENTITY	Melatonin inhibits luteinizing_hormone_releasing_hormone -LRB- LHRH -RRB- induction of LH release from fetal rat pituitary cells .
20663046	0	Melatonin	0,9	matrix_metalloproteinase-9	32,58	Melatonin	matrix metalloproteinase-9	MESH:D008550	17395(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|postischemic postischemic|dep|activation activation|amod|END_ENTITY	Melatonin inhibits postischemic matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- activation via dual modulation of plasminogen/plasmin system and endogenous MMP inhibitor in mice subjected to transient focal cerebral_ischemia .
26980735	0	Melatonin	0,9	matrix_metalloproteinase-9	73,99	Melatonin	matrix metalloproteinase-9	MESH:D008550	4318	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|suppressing suppressing|dobj|activation activation|amod|END_ENTITY	Melatonin inhibits TPA-induced oral_cancer cell migration by suppressing matrix_metalloproteinase-9 activation through the histone acetylation .
10842331	0	Melatonin	0,9	mt1	113,116	Melatonin	mt1	MESH:D008550	644314	Chemical	Gene	induction|compound|START_ENTITY induction|nmod|structures structures|acl:relcl|dependent dependent|nmod|expression expression|nmod|receptor receptor|amod|END_ENTITY	Melatonin induction of filamentous structures in non-neuronal cells that is dependent on expression of the human mt1 melatonin receptor .
12519889	0	Melatonin	4,13	mt1	0,3	Melatonin	mt1	MESH:D008550	644314	Chemical	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	mt1 Melatonin receptor in the primate adrenal gland : inhibition of adrenocorticotropin-stimulated cortisol production by melatonin .
18237195	0	Melatonin	0,9	myeloperoxidase	36,51	Melatonin	myeloperoxidase	MESH:D008550	4353	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Melatonin is a potent inhibitor for myeloperoxidase .
18855270	0	Melatonin	0,9	myeloperoxidase	93,108	Melatonin	myeloperoxidase	MESH:D008550	303413(Tax:10116)	Chemical	Gene	protects|nsubj|START_ENTITY protects|parataxis|role role|nmod|activity activity|amod|END_ENTITY	Melatonin protects myocardium from ischemia-reperfusion injury in hypertensive rats : role of myeloperoxidase activity .
22512552	0	Melatonin	0,9	nitric_oxide_synthase	31,52	Melatonin	nitric oxide synthase	MESH:D008550	4842	Chemical	Gene	analogs|amod|START_ENTITY analogs|nmod|END_ENTITY	Melatonin synthetic analogs as nitric_oxide_synthase inhibitors .
10421427	0	Melatonin	0,9	p53	20,23	Melatonin	p53	MESH:D008550	7157	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Melatonin increases p53 and p21WAF1 expression in MCF-7 human breast_cancer cells in vitro .
10453534	0	Melatonin	1,10	prolactin	36,45	Melatonin	prolactin	MESH:D008550	24683(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	-LSB- Melatonin inhibits TRH-stimulating prolactin gene expression of anterior pituitary cells in newborn rat in vitro -RSB- .
10810509	0	Melatonin	0,9	prolactin	24,33	Melatonin	prolactin	MESH:D008550	443317(Tax:9940)	Chemical	Gene	modulation|compound|START_ENTITY modulation|nmod|secretion secretion|compound|END_ENTITY	Melatonin modulation of prolactin and gonadotrophin secretion .
2646422	0	Melatonin	0,9	prolactin	21,30	Melatonin	prolactin	MESH:D008550	24683(Tax:10116)	Chemical	Gene	effects|nsubj|START_ENTITY effects|nmod|secretion secretion|compound|END_ENTITY	Melatonin effects on prolactin secretion in pituitary-grafted male rats .
2656832	0	Melatonin	0,9	prolactin	21,30	Melatonin	prolactin	MESH:D008550	24683(Tax:10116)	Chemical	Gene	effects|nsubj|START_ENTITY effects|nmod|secretion secretion|compound|END_ENTITY	Melatonin effects on prolactin secretion in pituitary-grafted female rats .
8519656	0	Melatonin	0,9	prolactin	44,53	Melatonin	prolactin	MESH:D008550	5617	Chemical	Gene	blocks|nsubj|START_ENTITY blocks|dobj|effects effects|nmod|END_ENTITY	Melatonin blocks the stimulatory effects of prolactin on human breast_cancer cell growth in culture .
8548063	0	Melatonin	0,9	proopiomelanocortin	18,37	Melatonin	proopiomelanocortin	MESH:D008550	24664(Tax:10116)	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|expression expression|compound|END_ENTITY	Melatonin affects proopiomelanocortin gene expression in the immune organs of the rat .
17910598	0	Melatonin	0,9	quinone_reductase-2	51,70	Melatonin	quinone reductase-2	MESH:D008550	4835	Chemical	Gene	START_ENTITY|nmod|co-substrate co-substrate|nmod|END_ENTITY	Melatonin as a naturally occurring co-substrate of quinone_reductase-2 , the putative MT3 melatonin membrane receptor : hypothesis and significance .
20210852	0	Melatonin	0,9	serotonin_transporter	19,40	Melatonin	serotonin transporter	MESH:D008550	6532	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	Melatonin inhibits serotonin_transporter activity in intestinal epithelial cells .
19409439	0	Melatonin	0,9	synaptophysin	80,93	Melatonin	synaptophysin	MESH:D008550	24804(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|levels levels|compound|END_ENTITY	Melatonin attenuates methamphetamine-induced reduction_of_tyrosine_hydroxylase , synaptophysin and growth-associated_protein-43 levels in the neonatal rat brain .
21297449	0	Melatonin	0,9	tissue_factor_pathway_inhibitor	32,63	Melatonin	tissue factor pathway inhibitor	MESH:D008550	7035	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|nmod|END_ENTITY	Melatonin stimulates release of tissue_factor_pathway_inhibitor from the vascular endothelium .
12716016	0	Melatonin	0,9	tumor_necrosis_factor_alpha	52,79	Melatonin	tumor necrosis factor alpha	MESH:D008550	21926(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Melatonin increases interleukin-1beta and decreases tumor_necrosis_factor_alpha in the brain of mice infected with the Venezuelan_equine_encephalomyelitis virus .
11841594	0	Melatonin	0,9	tyrosine_hydroxylase	18,38	Melatonin	tyrosine hydroxylase	MESH:D008550	25085(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Melatonin induces tyrosine_hydroxylase mRNA expression in the ventral mesencephalon but not in the hypothalamus .
21913973	0	Melatonin	0,9	vascular_endothelial_growth_factor	146,180	Melatonin	vascular endothelial growth factor	MESH:D008550	7422	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|dobj|PANC-1-induced PANC-1-induced|acl:relcl|endothelial endothelial|advcl|inhibiting inhibiting|dobj|expression expression|compound|END_ENTITY	Melatonin prevents human pancreatic_carcinoma cell PANC-1-induced human umbilical vein endothelial cell proliferation and migration by inhibiting vascular_endothelial_growth_factor expression .
23358453	0	Melatonin	0,9	vascular_endothelial_growth_factor	37,71	Melatonin	vascular endothelial growth factor	MESH:D008550	7422	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Melatonin inhibits the expression of vascular_endothelial_growth_factor in pancreatic_cancer cells .
21078367	0	Melatonin	0,9	vesicular_monoamine_transporter-2	57,90	Melatonin	vesicular monoamine transporter-2	MESH:D008550	25549(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|decrease decrease|nmod|expression expression|amod|END_ENTITY	Melatonin attenuates the amphetamine-induced decrease in vesicular_monoamine_transporter-2 expression in postnatal rat striatum .
19800928	0	Melittin	0,8	phospholipase_A	79,94	Melittin	phospholipase A	MESH:D008555	57110	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|activation activation|nmod|END_ENTITY	Melittin promotes exocytosis in neuroendocrine cells through the activation of phospholipase_A .
11370672	0	Melittin	0,8	phospholipase_A2	118,134	Melittin	phospholipase A2	MESH:D008555	18784(Tax:10090)	Chemical	Gene	exerts|nsubj|START_ENTITY exerts|parataxis|lack lack|nmod|activation activation|nmod|END_ENTITY	Melittin exerts multiple effects on the release of free fatty_acids from L1210 cells : lack of selective activation of phospholipase_A2 by melittin .
1851918	0	Melittin	0,8	phospholipase_A2	115,131	Melittin	phospholipase A2	MESH:D008555	151056	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|parataxis|arachidonic_acid arachidonic_acid|nmod|link link|nmod|END_ENTITY	Melittin stimulates phosphoinositide hydrolysis and placental lactogen release : arachidonic_acid as a link between phospholipase_A2 and phospholipase C signal-transduction pathways .
14742370	0	Meloxicam	0,9	COX-2	22,27	Meloxicam	COX-2	MESH:C065757	26198(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Meloxicam , a specific COX-2 inhibitor , does not enhance the isoflurane minimum alveolar concentration reduction produced by morphine in the rat .
15989631	0	Meloxicam	0,9	COX-2	23,28	Meloxicam	COX-2	MESH:C065757	4513	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Meloxicam : a selective COX-2 inhibitor non-steroidal anti-inflammatory drug .
21757922	0	Meloxicam	0,9	COX-2	13,18	Meloxicam	COX-2	MESH:C065757	29527(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Meloxicam , a COX-2 inhibitor , ameliorates ischemia/reperfusion injury in non-heart-beating donor livers .
24675684	0	Meloxicam	0,9	COX-2	77,82	Meloxicam	COX-2	MESH:C065757	4513	Chemical	Gene	executes|nsubj|START_ENTITY executes|nmod|hepatocellular_carcinoma hepatocellular_carcinoma|nmod|END_ENTITY	Meloxicam executes its antitumor effects against hepatocellular_carcinoma in COX-2 - dependent and - independent pathways .
9219316	0	Meloxicam	0,9	COX-2	21,26	Meloxicam	COX-2	MESH:C065757	4513	Chemical	Gene	START_ENTITY|dep|inhibition inhibition|compound|END_ENTITY	Meloxicam : selective COX-2 inhibition in clinical practice .
17552878	0	Meloxicam	0,9	cyclooxygenase-2	27,43	Meloxicam	cyclooxygenase-2	MESH:C065757	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Meloxicam , an inhibitor of cyclooxygenase-2 , increases the level of serum G-CSF and might be usable as an auxiliary means in G-CSF therapy .
19078323	0	Meloxicam	0,9	cyclooxygenase-2	42,58	Meloxicam	cyclooxygenase-2	MESH:C065757	5743	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|amod|END_ENTITY	Meloxicam clinical data on a preferential cyclooxygenase-2 inhibitor .
11093076	0	Meloxicam	0,9	cyclooxygenase_2	53,69	Meloxicam	cyclooxygenase 2	MESH:C065757	29527(Tax:10116)	Chemical	Gene	inhibits|compound|START_ENTITY prostaglandin_E|nsubj|inhibits prostaglandin_E|dobj|generation generation|nmod|END_ENTITY	Meloxicam inhibits prostaglandin_E -LRB- 2 -RRB- generation via cyclooxygenase_2 in the inflammatory site but not that via cyclooxygenase_1 in the stomach .
16953674	0	Meloxicam	0,9	cyclooxygenase_2	13,29	Meloxicam	cyclooxygenase 2	MESH:C065757	19225(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Meloxicam , a cyclooxygenase_2 inhibitor , supports hematopoietic recovery in gamma-irradiated mice .
12649767	0	Melperone	0,9	CYP2D6	33,39	Melperone	CYP2D6	MESH:C008522	1565	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Melperone is an inhibitor of the CYP2D6 catalyzed O-demethylation of venlafaxine .
25940834	0	Melperone	0,9	CYP2D6	81,87	Melperone	CYP2D6	MESH:C008522	1565	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Melperone but not bisoprolol or metoprolol is a clinically relevant inhibitor of CYP2D6 : evidence from a therapeutic drug monitoring survey .
19551763	0	Melperone	0,9	prolactin	79,88	Melperone	prolactin	MESH:C008522	5617	Chemical	Gene	START_ENTITY|appos|drug drug|nmod|effect effect|nmod|END_ENTITY	Melperone , an aytpical antipsychotic drug with clozapine-like effect on plasma prolactin : contrast with typical neuroleptics .
17971830	0	Memantine	0,9	BDNF	22,26	Memantine	BDNF	MESH:D008559	627	Chemical	Gene	upregulates|amod|START_ENTITY END_ENTITY|nsubj|upregulates	Memantine upregulates BDNF and prevents dopamine deficits_in_SIV-infected macaques : a novel pharmacological action of memantine .
8973791	0	Memantine	0,9	HSP70	37,42	Memantine	HSP70	MESH:D008559	266759(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Memantine induces heat_shock protein HSP70 in the posterior cingulate cortex , retrosplenial cortex and dentate gyrus of rat brain .
25539933	0	Menthol	0,7	TRPM8	136,141	Menthol	TRPM8	MESH:D008610	171384(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|parataxis|role role|nmod|END_ENTITY	Menthol suppresses laryngeal C-fiber hypersensitivity to cigarette smoke in a rat model of gastroesophageal_reflux_disease : the role of TRPM8 .
15192105	0	Mepyramine	0,10	histamine_H1_receptor	14,35	Mepyramine	histamine H1 receptor	MESH:D011738	100135539(Tax:10141)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Mepyramine , a histamine_H1_receptor inverse agonist , binds preferentially to a G protein-coupled form of the receptor and sequesters G protein .
19386698	0	Mer	0,3	MerTK	21,26	Mer	MerTK	null	17289(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	Mer tyrosine kinase -LRB- MerTK -RRB- promotes macrophage survival following exposure to oxidative stress .
16434617	0	Merbarone	0,9	caspase-activated_DNase	32,55	Merbarone	caspase-activated DNase	MESH:C045459	1677	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|nmod|END_ENTITY	Merbarone induces activation of caspase-activated_DNase and excision of chromosomal DNA loops from the nuclear matrix .
8057292	0	Mercaptoacyl_amino_acid	0,23	atriopeptidase	38,52	Mercaptoacyl amino acid	atriopeptidase	null	4311	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Mercaptoacyl_amino_acid inhibitors of atriopeptidase .
25259884	0	Mercaptopteridine	27,44	CO2	0,3	Mercaptopteridine	CO2	null	717	Chemical	Gene	Catalyzed|nmod|START_ENTITY Catalyzed|nsubj|Reduction Reduction|compound|END_ENTITY	CO2 Reduction Catalyzed by Mercaptopteridine on Glassy Carbon .
8449215	0	Mercuric_chloride	0,17	interferon-gamma	40,56	Mercuric chloride	interferon-gamma	MESH:D008627	25712(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY production|compound|END_ENTITY	Mercuric_chloride down-regulates T cell interferon-gamma production in brown Norway but not in Lewis rats ; role of glutathione .
20837117	0	Mercury	0,7	CYP1A1	22,28	Mercury	CYP1A1	MESH:D008628	1543	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Mercury modulates the CYP1A1 at transcriptional and posttranslational levels in human hepatoma HepG2 cells .
25673500	0	Mercury	0,7	Neprilysin	42,52	Mercury	Neprilysin	MESH:D008628	4311	Chemical	Gene	Reduces|nsubj|START_ENTITY Reduces|dobj|Activity Activity|nmod|END_ENTITY	Mercury Reduces the Enzymatic Activity of Neprilysin in Differentiated SH-SY5Y Cells .
19879273	0	Mesalamine	0,10	beta-catenin	31,43	Mesalamine	beta-catenin	MESH:D019804	1499	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	Mesalamine inhibits epithelial beta-catenin activation in chronic ulcerative_colitis .
18495657	0	Mesalazine	0,10	CDC25A	32,38	Mesalazine	CDC25A	MESH:D019804	993	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nummod|END_ENTITY	Mesalazine negatively regulates CDC25A protein expression and promotes accumulation of colon_cancer cells in S phase .
26336590	0	Mesalazine	63,73	Cytochrome_P450	21,36	Mesalazine	Cytochrome P450	MESH:D019804	4051	Chemical	Gene	Induction|nmod|START_ENTITY Induction|compound|END_ENTITY	Measurement of Human Cytochrome_P450 Enzyme Induction Based on Mesalazine and Mosapride_Citrate Treatments Using a Luminescent Assay .
11151876	0	Mesalazine	0,10	NF-kappaB	55,64	Mesalazine	NF-kappaB	MESH:D019804	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	Mesalazine inhibits activation of transcription factor NF-kappaB in inflamed mucosa of patients with ulcerative_colitis .
26705539	0	Mesendogen	0,10	TRPM6	33,38	Mesendogen	TRPM6	null	140803	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Mesendogen , a novel inhibitor of TRPM6 , promotes mesoderm and definitive endoderm differentiation of human embryonic stem cells through alteration of magnesium homeostasis .
24279603	0	Meserine	0,8	AChE	28,32	Meserine	AChE	null	11423(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Meserine , a novel carbamate AChE inhibitor , ameliorates scopolamine-induced dementia and alleviates amyloidogenesis of APP/PS1 transgenic_mice .
16387763	0	Met3534-Ala4271	12,27	ryanodine_receptor	42,60	Met3534-Ala4271	ryanodine receptor	null	6261	Chemical	Gene	region|compound|START_ENTITY region|nmod|END_ENTITY	Role of the Met3534-Ala4271 region of the ryanodine_receptor in the regulation of Ca2 + release induced by calmodulin binding domain peptide .
11772408	0	Metallothionein	0,15	tumour_necrosis_factor	56,78	Metallothionein	tumour necrosis factor	null	21926(Tax:10090)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|compound|END_ENTITY	Metallothionein modulates lipopolysaccharide-stimulated tumour_necrosis_factor expression in mouse peritoneal macrophages .
22876963	0	Metavanadate	0,12	VHZ	51,54	Metavanadate	VHZ	MESH:D014638	54935	Chemical	Gene	START_ENTITY|nmod|site site|nmod|END_ENTITY	Metavanadate at the active site of the phosphatase VHZ .
12086935	0	Metformin	0,9	AMP-activated_protein_kinase	20,48	Metformin	AMP-activated protein kinase	MESH:D008687	78975(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|activity activity|amod|END_ENTITY	Metformin increases AMP-activated_protein_kinase activity in skeletal muscle of subjects with type 2 diabetes .
20854376	0	Metformin	0,9	AMP-activated_protein_kinase	20,48	Metformin	AMP-activated protein kinase	MESH:D008687	5563	Chemical	Gene	action|compound|START_ENTITY action|nmod|END_ENTITY	Metformin action on AMP-activated_protein_kinase : a translational research approach to understanding a potential new therapeutic target .
23523792	0	Metformin	0,9	AMP-activated_protein_kinase	79,107	Metformin	AMP-activated protein kinase	MESH:D008687	78975(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|activating activating|dobj|END_ENTITY	Metformin induces up-regulation of blood-brain barrier functions by activating AMP-activated_protein_kinase in rat brain microvascular endothelial cells .
22644486	0	Metformin	0,9	AMPK	25,29	Metformin	AMPK	MESH:D008687	5563	Chemical	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Metformin interacts with AMPK through binding to y subunit .
26196392	0	Metformin	0,9	AMPK	18,22	Metformin	AMPK	MESH:D008687	5562	Chemical	Gene	Induced|compound|START_ENTITY END_ENTITY|nsubj|Induced	Metformin Induced AMPK Activation , G0/G1 Phase Cell Cycle Arrest and the Inhibition of Growth of Esophageal_Squamous_Cell_Carcinomas In Vitro and In Vivo .
26196392	0	Metformin	0,9	AMPK	18,22	Metformin	AMPK	MESH:D008687	5562	Chemical	Gene	Induced|compound|START_ENTITY END_ENTITY|nsubj|Induced	Metformin Induced AMPK Activation , G0/G1 Phase Cell Cycle Arrest and the Inhibition of Growth of Esophageal_Squamous_Cell_Carcinomas In Vitro and In Vivo .
26962099	0	Metformin	0,9	Aquaporin_2	64,75	Metformin	Aquaporin 2	MESH:D008687	25386(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Metformin , an AMPK activator , stimulates the phosphorylation of Aquaporin_2 and Urea Transporter A1 in Inner Medullary Collecting Ducts .
26963617	0	Metformin	11,20	C-Reactive_Protein	126,144	Metformin	C-Reactive Protein	MESH:D008687	1401	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of Metformin on Tissue Oxidative and Dicarbonyl Stress in Transgenic Spontaneously Hypertensive Rats Expressing Human C-Reactive_Protein .
14557435	0	Metformin	0,9	C-reactive_protein	24,42	Metformin	C-reactive protein	MESH:D008687	1401	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|levels levels|amod|END_ENTITY	Metformin reduces serum C-reactive_protein levels in women with polycystic_ovary_syndrome .
16108864	0	Metformin	0,9	C-reactive_protein	18,36	Metformin	C-reactive protein	MESH:D008687	1401	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	Metformin reduces C-reactive_protein but not complement factor C3 in overweight patients with Type_2_diabetes_mellitus .
25110054	0	Metformin	0,9	CYP1A1	21,27	Metformin	CYP1A1	MESH:D008687	1543	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Metformin suppresses CYP1A1 and CYP1B1 expression in breast_cancer cells by down-regulating aryl_hydrocarbon_receptor expression .
26642701	0	Metformin	22,31	Chemerin	35,43	Metformin	Chemerin	MESH:D008687	5919	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Therapeutic Effect of Metformin on Chemerin in Non-Obese Patients with Non-Alcoholic_Fatty_Liver_Disease -LRB- NAFLD -RRB- .
26622703	0	Metformin	0,9	E-cadherin	22,32	Metformin	E-cadherin	MESH:D008687	12550(Tax:10090)	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	Metformin upregulates E-cadherin and inhibits B16F10 cell motility , invasion and migration .
10448935	0	Metformin	0,9	GLUT4	136,141	Metformin	GLUT4	MESH:D008687	6517	Chemical	Gene	interaction|compound|START_ENTITY using|nsubj|interaction using|advcl|expressing expressing|dobj|END_ENTITY	Metformin interaction with insulin-regulated glucose uptake , using the Xenopus_laevis oocyte model expressing the mammalian transporter GLUT4 .
23135276	0	Metformin	0,9	GLUT4	43,48	Metformin	GLUT4	MESH:D008687	20528(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|translocation translocation|appos|END_ENTITY	Metformin regulates glucose_transporter_4 -LRB- GLUT4 -RRB- translocation through AMP-activated protein kinase -LRB- AMPK -RRB- - mediated Cbl/CAP signaling in 3T3-L1 preadipocyte cells .
23595973	0	Metformin	0,9	GLUT4	117,122	Metformin	GLUT4	MESH:D008687	6517	Chemical	Gene	augments|nsubj|START_ENTITY augments|dobj|levels levels|nmod|molecules molecules|acl:relcl|regulate regulate|dobj|expression expression|nmod|END_ENTITY	Metformin augments the levels of molecules that regulate the expression of the insulin-dependent glucose transporter GLUT4 in the endometria of hyperinsulinemic PCOS patients .
8325447	0	Metformin	0,9	GLUT4	48,53	Metformin	GLUT4	MESH:D008687	25139(Tax:10116)	Chemical	Gene	blocks|nsubj|START_ENTITY blocks|dobj|downregulation downregulation|nmod|END_ENTITY	Metformin blocks downregulation of cell surface GLUT4 caused by chronic insulin treatment of rat adipocytes .
21769504	0	Metformin	0,9	Hsp60	32,37	Metformin	Hsp60	MESH:D008687	3329	Chemical	Gene	induced|nsubj|START_ENTITY induced|dobj|expression expression|nmod|END_ENTITY	Metformin induced expression of Hsp60 in human THP-1 monocyte cells .
27009398	0	Metformin	0,9	IGFBP-2	21,28	Metformin	IGFBP-2	MESH:D008687	16008(Tax:10090)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	Metformin stimulates IGFBP-2 gene expression through PPARalpha in diabetic states .
26152715	0	Metformin	0,9	IL-10	169,174	Metformin	IL-10	MESH:D008687	3586	Chemical	Gene	Inhibits|compound|START_ENTITY Inhibits|dep|Oxidoreductase Oxidoreductase|nmod|Induction Induction|nmod|Interleukin-1b Interleukin-1b|appos|END_ENTITY	Metformin Inhibits the Production of Reactive Oxygen Species from NADH : Ubiquinone Oxidoreductase to Limit Induction of Interleukin-1b -LRB- IL-1b -RRB- and Boosts Interleukin-10 -LRB- IL-10 -RRB- in Lipopolysaccharide -LRB- LPS -RRB- - activated Macrophages .
26152715	0	Metformin	0,9	IL-1b	135,140	Metformin	IL-1b	MESH:D008687	3553	Chemical	Gene	Inhibits|compound|START_ENTITY Inhibits|dep|Oxidoreductase Oxidoreductase|nmod|Induction Induction|nmod|Interleukin-1b Interleukin-1b|appos|END_ENTITY	Metformin Inhibits the Production of Reactive Oxygen Species from NADH : Ubiquinone Oxidoreductase to Limit Induction of Interleukin-1b -LRB- IL-1b -RRB- and Boosts Interleukin-10 -LRB- IL-10 -RRB- in Lipopolysaccharide -LRB- LPS -RRB- - activated Macrophages .
25370454	0	Metformin	0,9	IL-22	20,25	Metformin	IL-22	MESH:D008687	50929(Tax:10090)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|secretion secretion|compound|END_ENTITY	Metformin decreases IL-22 secretion to suppress tumor growth in an orthotopic mouse model of hepatocellular_carcinoma .
21316309	0	Metformin	0,9	IL-8	20,24	Metformin	IL-8	MESH:D008687	3576	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	Metformin modulates IL-8 , IL-1b , ICAM and IGFBP-1 expression in human endometrial stromal cells .
26534614	0	Metformin	124,133	Insulin	115,122	Metformin	Insulin	MESH:D008687	3630	Chemical	Gene	Insulin|appos|START_ENTITY Insulin|appos|END_ENTITY	Efficacy And Safety of Antidiabetic Drugs Available on Brazilian Public Health System -LRB- Sus -RRB- - Regular Insulin , Nph Insulin , Metformin , Glibenclamide_And_Gliclazide - In Treatment of Type 2 Diabetes -LRB- T2dm -RRB- - Systematic Review And Meta-Analysis .
26618447	0	Metformin	0,9	Insulin	68,75	Metformin	Insulin	MESH:D008687	3630	Chemical	Gene	Volume|compound|START_ENTITY Volume|nmod|Subjects Subjects|nmod|Resistance Resistance|compound|END_ENTITY	Metformin Decreases Thyroid Volume and Nodule Size in Subjects with Insulin Resistance : A Preliminary Study .
26831122	0	Metformin	11,20	Insulin	109,116	Metformin	Insulin	MESH:D008687	3630	Chemical	Gene	Training|compound|START_ENTITY Effects|nmod|Training Effects|nmod|Resistance Resistance|compound|END_ENTITY	Effects of Metformin and Exercise Training , Alone or in Combination , on Cardiac Function in Individuals with Insulin Resistance .
26075749	0	Metformin	0,9	NNAT	67,71	Metformin	NNAT	MESH:D008687	4826	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|pathway pathway|compound|END_ENTITY	Metformin induces ER stress-dependent apoptosis through miR-708-5p / NNAT pathway in prostate_cancer .
16272756	0	Metformin	0,9	OCT2	71,75	Metformin	OCT2	MESH:D008687	6582	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1 .
26327616	0	Metformin	93,102	OCT2	71,75	Metformin	OCT2	MESH:D008687	6582	Chemical	Gene	Comparison|nmod|START_ENTITY Inhibition|dep|Comparison Inhibition|nmod|END_ENTITY	Substrate-Dependent Inhibition of the Human Organic Cation Transporter OCT2 : A Comparison of Metformin with Experimental Substrates .
21054339	0	Metformin	0,9	P-glycoprotein	19,33	Metformin	P-glycoprotein	MESH:D008687	5243	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Metformin inhibits P-glycoprotein expression via the NF-kB pathway and CRE transcriptional activity through AMPK activation .
24288442	0	Metformin	0,9	PEDF	47,51	Metformin	PEDF	MESH:D008687	287526(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Metformin inhibits expression and secretion of PEDF in adipocyte and hepatocyte via promoting AMPK phosphorylation .
26987032	0	Metformin	0,9	PEDF	107,111	Metformin	PEDF	MESH:D008687	57104	Chemical	Gene	inhibits_prostate_cancer|nsubj|START_ENTITY inhibits_prostate_cancer|nmod|upregulation upregulation|nmod|expression expression|compound|END_ENTITY	Metformin inhibits_prostate_cancer cell proliferation , migration , and tumor growth through upregulation of PEDF expression .
24428821	0	Metformin	0,9	PGC-1a	18,24	Metformin	PGC-1a	MESH:D008687	19017(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Metformin induces PGC-1a expression and selectively affects hepatic PGC-1a functions .
16902066	0	Metformin	0,9	PGC-1alpha	24,34	Metformin	PGC-1alpha	MESH:D008687	83516(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|protein protein|compound|END_ENTITY	Metformin increases the PGC-1alpha protein and oxidative enzyme activities possibly via AMPK phosphorylation in skeletal muscle in vivo .
24480115	0	Metformin	0,9	PI3K	20,24	Metformin	PI3K	MESH:D008687	5293	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|compound|END_ENTITY	Metformin modulates PI3K and GLUT4 expression and Akt/PKB phosphorylation in human endometrial stromal cells after stimulation with androgen and insulin .
27009398	0	Metformin	0,9	PPARalpha	53,62	Metformin	PPARalpha	MESH:D008687	19013(Tax:10090)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|END_ENTITY	Metformin stimulates IGFBP-2 gene expression through PPARalpha in diabetic states .
21540236	0	Metformin	0,9	REDD1	86,91	Metformin	REDD1	MESH:D008687	54541	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Metformin , independent of AMPK , induces mTOR inhibition and cell-cycle arrest through REDD1 .
20857458	0	Metformin	0,9	Rab4	18,22	Metformin	Rab4	MESH:D008687	19341(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Metformin induces Rab4 through AMPK and modulates GLUT4 translocation in skeletal muscle cells .
17909097	0	Metformin	0,9	SHP	132,135	Metformin	SHP	MESH:D008687	23957(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|regulation regulation|nmod|END_ENTITY	Metformin inhibits hepatic gluconeogenesis through AMP-activated protein kinase-dependent regulation of the orphan nuclear receptor SHP .
24372553	0	Metformin	0,9	SIRT1	88,93	Metformin	SIRT1	MESH:D008687	93759(Tax:10090)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	Metformin modulates hyperglycaemia-induced endothelial senescence and apoptosis through SIRT1 .
23166782	0	Metformin	0,9	SIRT3	40,45	Metformin	SIRT3	MESH:D008687	64384(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|nmod|END_ENTITY	Metformin reduces hepatic expression of SIRT3 , the mitochondrial deacetylase controlling energy metabolism .
24762600	0	Metformin	0,9	SIRT3	97,102	Metformin	SIRT3	MESH:D008687	293615(Tax:10116)	Chemical	Gene	ameliorates|nsubj|START_ENTITY ameliorates|ccomp|rat rat|nmod|upregulation upregulation|nmod|END_ENTITY	Metformin ameliorates insulin resistance in L6 rat skeletal muscle cells through upregulation of SIRT3 .
18681789	1	Metformin	32,41	STK11	77,82	Metformin	STK11	MESH:D008687	6794	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Metformin , ovulation and polymorphism of the STK11 gene in polycystic_ovary_syndrome .
24823468	0	Metformin	0,9	StAR	19,23	Metformin	StAR	MESH:D008687	6770	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Metformin inhibits StAR expression in human endometriotic stromal cells via AMPK-mediated disruption of CREB-CRTC2 complex formation .
22189713	0	Metformin	0,9	Stat3	18,23	Metformin	Stat3	MESH:D008687	6774	Chemical	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Metformin targets Stat3 to inhibit cell growth and induce apoptosis in triple-negative breast_cancers .
24577086	0	Metformin	0,9	Stat3	99,104	Metformin	Stat3	MESH:D008687	6774	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Metformin promotes autophagy and apoptosis in esophageal_squamous_cell_carcinoma by downregulating Stat3 signaling .
26497205	0	Metformin	0,9	TGF-b	91,96	Metformin	TGF-b	MESH:D008687	7040	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|nmod|inhibition inhibition|nmod|END_ENTITY	Metformin attenuates gefitinib-induced exacerbation of pulmonary_fibrosis by inhibition of TGF-b signaling pathway .
21769504	0	Metformin	0,9	THP-1	47,52	Metformin	THP-1	MESH:D008687	2736	Chemical	Gene	induced|nsubj|START_ENTITY induced|dobj|expression expression|nmod|Hsp60 Hsp60|nmod|cells cells|compound|END_ENTITY	Metformin induced expression of Hsp60 in human THP-1 monocyte cells .
26117007	0	Metformin	11,20	THP-1	72,77	Metformin	THP-1	MESH:D008687	2736	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Effect of Metformin on Proliferation , Differentiation and Apoptosis of THP-1 Cells -RSB- .
26927374	0	Metformin	1,10	THP-1	20,25	Metformin	THP-1	MESH:D008687	2736	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	-LSB- Metformin inhibits THP-1 macrophage-derived foam cell formation induced by lipopolysaccharide -RSB- .
24009539	0	Metformin	0,9	TNF-a	25,30	Metformin	TNF-a	MESH:D008687	21926(Tax:10090)	Chemical	Gene	Secretion|compound|START_ENTITY Secretion|compound|END_ENTITY	Metformin Down-regulates TNF-a Secretion via Suppression of Scavenger Receptors in Macrophages .
25590211	0	Metformin	0,9	TNF-a	52,57	Metformin	TNF-a	MESH:D008687	7124	Chemical	Gene	Reverts|compound|START_ENTITY Reverts|dep|Secretion Secretion|nmod|Induced Induced|nmod|END_ENTITY	Metformin Reverts the Secretion of CXCL8 Induced by TNF-a in Primary Cultures of Human Thyroid Cells : An Additional Indirect Anti-Tumor Effect of the Drug .
16039647	0	Metformin	0,9	adiponectin	18,29	Metformin	adiponectin	MESH:D008687	9370	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|iobj|protein protein|compound|END_ENTITY	Metformin reduces adiponectin protein expression and release in 3T3-L1 adipocytes involving activation of AMP activated protein kinase .
21907790	0	Metformin	0,9	adiponectin	82,93	Metformin	adiponectin	MESH:D008687	9370	Chemical	Gene	protects|nsubj|START_ENTITY protects|dobj|involvement involvement|nmod|system system|amod|END_ENTITY	Metformin protects against doxorubicin-induced cardiotoxicity : involvement of the adiponectin cardiac system .
25894097	0	Metformin	0,9	androgen_receptor	94,111	Metformin	androgen receptor	MESH:D008687	367	Chemical	Gene	represses|nsubj|START_ENTITY represses|advcl|targeting targeting|dobj|END_ENTITY	Metformin represses androgen-dependent and androgen-independent prostate_cancers by targeting androgen_receptor .
25110054	0	Metformin	0,9	aryl_hydrocarbon_receptor	92,117	Metformin	aryl hydrocarbon receptor	MESH:D008687	196	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|expression expression|compound|END_ENTITY	Metformin suppresses CYP1A1 and CYP1B1 expression in breast_cancer cells by down-regulating aryl_hydrocarbon_receptor expression .
23987517	0	Metformin	0,9	corticotropin-releasing_hormone	36,67	Metformin	corticotropin-releasing hormone	MESH:D008687	1392	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|nmod|END_ENTITY	Metformin reduces the expression of corticotropin-releasing_hormone and urocortin in the endometrium of healthy women .
15039452	0	Metformin	0,9	dipeptidyl_peptidase_IV	122,145	Metformin	dipeptidyl peptidase IV	MESH:D008687	25253(Tax:10116)	Chemical	Gene	causes|nsubj|START_ENTITY causes|nmod|inhibitor inhibitor|amod|END_ENTITY	Metformin causes reduction of food intake and body weight_gain and improvement of glucose_intolerance in combination with dipeptidyl_peptidase_IV inhibitor in Zucker fa/fa rats .
26721779	0	Metformin	0,9	fms-like_tyrosine_kinase_1	79,105	Metformin	fms-like tyrosine kinase 1	MESH:D008687	2321	Chemical	Gene	START_ENTITY|dep|effects effects|nmod|END_ENTITY	Metformin as a prevention and treatment for preeclampsia : effects on soluble fms-like_tyrosine_kinase_1 and soluble endoglin secretion and endothelial_dysfunction .
23066988	0	Metformin	0,9	ghrelin	28,35	Metformin	ghrelin	MESH:D008687	59301(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|compound|END_ENTITY	Metformin directly inhibits ghrelin secretion through AMP-activated protein kinase in rat primary gastric cells .
11883961	0	Metformin	0,9	glucagon-like_peptide-1	59,82	Metformin	glucagon-like peptide-1	MESH:D008687	2641	Chemical	Gene	effects|compound|START_ENTITY effects|nmod|END_ENTITY	Metformin effects on dipeptidylpeptidase IV degradation of glucagon-like_peptide-1 .
11855850	0	Metformin	0,9	growth_hormone	51,65	Metformin	growth hormone	MESH:D008687	81668(Tax:10116)	Chemical	Gene	restores|nsubj|START_ENTITY restores|parataxis|END_ENTITY	Metformin restores responses to insulin but not to growth_hormone in Sprague-Dawley_rats .
23707609	0	Metformin	0,9	heme_oxygenase-1	19,35	Metformin	heme oxygenase-1	MESH:D008687	3162	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Metformin inhibits heme_oxygenase-1 expression in cancer cells through inactivation of Raf-ERK-Nrf2 signaling and AMPK-independent pathways .
10611182	0	Metformin	0,9	insulin	117,124	Metformin	insulin	MESH:D008687	3630	Chemical	Gene	treatment|compound|START_ENTITY reduces|nsubj|treatment reduces|dobj|response response|acl|human_chorionic_gonadotrophin human_chorionic_gonadotrophin|nmod|women women|nmod|polycystic_ovary_syndrome polycystic_ovary_syndrome|compound|END_ENTITY	Metformin treatment reduces ovarian cytochrome_P-450c17alpha response to human_chorionic_gonadotrophin in women with insulin resistance-related polycystic_ovary_syndrome .
11932281	0	Metformin	0,9	insulin	200,207	Metformin	insulin	MESH:D008687	3630	Chemical	Gene	therapy|compound|START_ENTITY therapy|dep|amelioration amelioration|acl|adrenocorticotropin adrenocorticotropin|nmod|resistance resistance|compound|END_ENTITY	Metformin therapy in obese adolescents with polycystic_ovary_syndrome and impaired_glucose_tolerance : amelioration of exaggerated adrenal response to adrenocorticotropin with reduction_of_insulinemia / insulin resistance .
12387512	0	Metformin	0,9	insulin	34,41	Metformin	insulin	MESH:D008687	3630	Chemical	Gene	therapy|compound|START_ENTITY therapy|nmod|END_ENTITY	Metformin adjunctive therapy with insulin improves glycemic control in patients with type_1_diabetes_mellitus : a pilot study .
14998944	0	Metformin	0,9	insulin	35,42	Metformin	insulin	MESH:D008687	3630	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	Metformin during pregnancy reduces insulin , insulin resistance , insulin secretion , weight , testosterone and development of gestational_diabetes : prospective longitudinal assessment of women with polycystic_ovary_syndrome from preconception throughout pregnancy .
15256315	0	Metformin	136,145	insulin	66,73	Metformin	insulin	MESH:D008687	3630	Chemical	Gene	diabetics|nmod|START_ENTITY related|nmod|diabetics related|nmod|levels levels|compound|END_ENTITY	Fatty_acid composition of erythrocyte phospholipids is related to insulin levels , secretion and resistance in obese_type_2 diabetics on Metformin .
16914073	0	Metformin	0,9	insulin	49,56	Metformin	insulin	MESH:D008687	3630	Chemical	Gene	START_ENTITY|dep|Effectively Effectively|acl|treating treating|dobj|resistance resistance|compound|END_ENTITY	Metformin and pioglitazone : Effectively treating insulin resistance .
1759920	0	Metformin	0,9	insulin	20,27	Metformin	insulin	MESH:D008687	3630	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|sensitivity sensitivity|compound|END_ENTITY	Metformin increases insulin sensitivity and basal glucose clearance in type 2 -LRB- non-insulin dependent -RRB- diabetes mellitus .
17984248	0	Metformin	0,9	insulin	84,91	Metformin	insulin	MESH:D008687	3630	Chemical	Gene	improves|nsubj|START_ENTITY improves|advmod|irrespective irrespective|nmod|resistance resistance|compound|END_ENTITY	Metformin improves polycystic_ovary_syndrome symptoms irrespective of pre-treatment insulin resistance .
19160294	0	Metformin	0,9	insulin	19,26	Metformin	insulin	MESH:D008687	3630	Chemical	Gene	added|nsubj|START_ENTITY added|nmod|therapy therapy|compound|END_ENTITY	Metformin added to insulin therapy for type_1_diabetes_mellitus in adolescents .
23928867	0	Metformin	0,9	insulin	29,36	Metformin	insulin	MESH:D008687	3630	Chemical	Gene	added|nsubj|START_ENTITY added|nmod|therapy therapy|compound|END_ENTITY	Metformin added to intensive insulin therapy reduces plasma levels of glycated but not oxidized low - density lipoprotein in young patients with type 1 diabetes and obesity in comparison with insulin alone : a pilot study .
25458330	0	Metformin	0,9	insulin	38,45	Metformin	insulin	MESH:D008687	3630	Chemical	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	Metformin in combination with various insulin secretagogues in type 2 diabetes and associated risk of cardiovascular_morbidity and mortality-A retrospective nationwide study .
25467617	0	Metformin	0,9	insulin	17,24	Metformin	insulin	MESH:D008687	3630	Chemical	Gene	START_ENTITY|nmod|treatment treatment|compound|END_ENTITY	Metformin versus insulin treatment in gestational_diabetes in pregnancy in a developing country .
3552772	0	Metformin	0,9	insulin	19,26	Metformin	insulin	MESH:D008687	3630	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|xcomp|binding binding|nsubj|END_ENTITY	Metformin enhances insulin binding to `` in vitro '' down regulated human fat cells .
6350337	0	Metformin	0,9	insulin	21,28	Metformin	insulin	MESH:D008687	3630	Chemical	Gene	normalizes|nsubj|START_ENTITY normalizes|dobj|END_ENTITY	Metformin normalizes insulin binding to monocytes from obese nondiabetic subjects and obese type II diabetic patients .
8339856	0	Metformin	0,9	insulin	47,54	Metformin	insulin	MESH:D008687	3630	Chemical	Gene	effects|nsubj|START_ENTITY effects|nmod|END_ENTITY	Metformin effects on peripheral sensitivity to insulin in non diabetic_obese subjects .
10456437	0	Metformin	0,9	insulin_receptor	20,36	Metformin	insulin receptor	MESH:D008687	3643	Chemical	Gene	modulates|compound|START_ENTITY END_ENTITY|nsubj|modulates	Metformin modulates insulin_receptor signaling in normal and cholesterol-treated human hepatoma cells -LRB- HepG2 -RRB- .
12629126	0	Metformin	0,9	insulin_receptor	28,44	Metformin	insulin receptor	MESH:D008687	3643	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|activation activation|compound|END_ENTITY	Metformin rapidly increases insulin_receptor activation in human liver and signals preferentially through insulin-receptor_substrate-2 .
15135305	0	Metformin	0,9	insulin_receptor	79,95	Metformin	insulin receptor	MESH:D008687	3643	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|acl|stimulate stimulate|dobj|kinase kinase|compound|END_ENTITY	Metformin -LRB- Glucophage -RRB- inhibits tyrosine phosphatase activity to stimulate the insulin_receptor tyrosine kinase .
1543016	0	Metformin	0,9	insulin_receptor	116,132	Metformin	insulin receptor	MESH:D008687	3643	Chemical	Gene	ameliorates|nsubj|START_ENTITY ameliorates|dobj|resistance resistance|nmod|patient patient|dep|description description|nmod|effects effects|compound|END_ENTITY	Metformin ameliorates extreme insulin resistance in a patient with anti-insulin_receptor antibodies : description of insulin_receptor and postreceptor effects in vivo and in vitro .
17658527	0	Metformin	0,9	leptin	42,48	Metformin	leptin	MESH:D008687	3952	Chemical	Gene	treatment|compound|START_ENTITY affect|nsubj|treatment affect|dobj|levels levels|compound|END_ENTITY	Metformin treatment does not affect total leptin levels and free leptin index in obese patients with polycystic_ovary_syndrome .
25681087	0	Metformin	95,104	mTOR	75,79	Metformin	mTOR	MESH:D008687	21977(Tax:10090)	Chemical	Gene	Signaling|nmod|START_ENTITY Signaling|compound|END_ENTITY	Prevention of Tumor Growth Driven by PIK3CA and HPV Oncogenes by Targeting mTOR Signaling with Metformin in Oral Squamous_Carcinomas Expressing OCT3 .
20444419	0	Metformin	0,9	mTORC1	41,47	Metformin	mTORC1	MESH:D008687	382056(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Metformin , independent of AMPK , inhibits mTORC1 in a rag GTPase-dependent manner .
23159620	0	Metformin	0,9	mTORC1	24,30	Metformin	mTORC1	MESH:D008687	382056(Tax:10090)	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|synthesis synthesis|amod|END_ENTITY	Metformin inhibition of mTORC1 activation , DNA synthesis and proliferation in pancreatic_cancer cells : dependence on glucose concentration and role of AMPK .
15652898	0	Metformin	0,9	mullerian-inhibiting_substance	24,54	Metformin	mullerian-inhibiting substance	MESH:D008687	268	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|levels levels|amod|END_ENTITY	Metformin reduces serum mullerian-inhibiting_substance levels in women with polycystic_ovary_syndrome after protracted treatment .
24791887	0	Metformin	0,9	nuclear_factor-kB	19,36	Metformin	nuclear factor-kB	MESH:D008687	309165(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	Metformin inhibits nuclear_factor-kB activation and inflammatory cytokines expression induced by high glucose via adenosine_monophosphate-activated protein kinase activation in rat glomerular mesangial cells in vitro .
21618594	0	Metformin	0,9	osteoprotegerin	21,36	Metformin	osteoprotegerin	MESH:D008687	25341(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Metformin stimulates osteoprotegerin and reduces RANKL expression in osteoblasts and ovariectomized rats .
25118792	0	Metformin	0,9	p38	24,27	Metformin	p38	MESH:D008687	1432	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|amod|END_ENTITY	Metformin combined with p38 MAPK inhibitor improves cisplatin sensitivity in cisplatin - resistant ovarian_cancer .
25760137	0	Metformin	0,9	p38	113,116	Metformin	p38	MESH:D008687	81649(Tax:10116)	Chemical	Gene	alleviates|nummod|START_ENTITY high|nmod:npmod|alleviates glucose|amod|high glucose|acl|mediated mediated|nmod|modulation modulation|nmod|expression expression|amod|END_ENTITY	Metformin alleviates high glucose - mediated oxidative stress in rat glomerular mesangial cells by modulation of p38 mitogen-activated protein kinase expression in vitro .
12669266	0	Metformin	0,9	plasminogen_activator_inhibitor-1	48,81	Metformin	plasminogen activator inhibitor-1	MESH:D008687	5054	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Metformin , but not thiazolidinediones , inhibits plasminogen_activator_inhibitor-1 production in human adipose tissue in vitro .
1713132	0	Metformin	0,9	plasminogen_activator_inhibitor-1	64,97	Metformin	plasminogen activator inhibitor-1	MESH:D008687	5054	Chemical	Gene	causes|nsubj|START_ENTITY causes|dobj|reduction reduction|nmod|occlusion occlusion|amod|END_ENTITY	Metformin causes a reduction in basal and post-venous occlusion plasminogen_activator_inhibitor-1 in type 2 diabetic patients .
9109854	0	Metformin	0,9	plasminogen_activator_inhibitor-1	58,91	Metformin	plasminogen activator inhibitor-1	MESH:D008687	5054	Chemical	Gene	therapy|compound|START_ENTITY associated|nsubjpass|therapy associated|nmod|decrease decrease|nmod|END_ENTITY	Metformin therapy is associated with a decrease in plasma plasminogen_activator_inhibitor-1 , lipoprotein -LRB- a -RRB- , and immunoreactive insulin levels in patients with the polycystic_ovary_syndrome .
21168492	0	Metformin	0,9	progesterone_receptor	19,40	Metformin	progesterone receptor	MESH:D008687	5241	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|compound|END_ENTITY	Metformin promotes progesterone_receptor expression via inhibition of mammalian_target_of_rapamycin -LRB- mTOR -RRB- in endometrial_cancer cells .
22424822	0	Metformin	0,9	resistin	27,35	Metformin	resistin	MESH:D008687	56729	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|concentrations concentrations|compound|END_ENTITY	Metformin decreases plasma resistin concentrations in pediatric patients with impaired_glucose_tolerance : a placebo-controlled randomized clinical trial .
26548416	0	Metformin	0,9	steroid_receptor_coactivator_2	120,150	Metformin	steroid receptor coactivator 2	MESH:D008687	10499	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Metformin inhibits hepatocellular glucose , lipid and cholesterol biosynthetic pathways by transcriptionally suppressing steroid_receptor_coactivator_2 -LRB- SRC-2 -RRB- .
18375437	0	Metformin	0,9	vaspin	34,40	Metformin	vaspin	MESH:D008687	145264	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|END_ENTITY	Metformin decreases the adipokine vaspin in overweight women with polycystic_ovary_syndrome concomitant with improvement in insulin sensitivity and a decrease in insulin resistance .
12023039	0	Methadone	0,9	CCR5	18,22	Methadone	CCR5	MESH:D008691	1234	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Methadone induces CCR5 and promotes AIDS_virus_infection .
20410453	0	Methadone	0,9	CYP19	56,61	Methadone	CYP19	MESH:D008691	1588	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	Methadone : a substrate and mechanism-based inhibitor of CYP19 -LRB- aromatase -RRB- .
16338275	0	Methadone	0,9	CYP2B6	36,42	Methadone	CYP2B6	MESH:D008691	1555	Chemical	Gene	genotypes|ccomp|START_ENTITY genotypes|nsubj|END_ENTITY	Methadone enantiomer plasma levels , CYP2B6 , CYP2C19 , and CYP2C9 genotypes , and response to treatment .
25897175	0	Methadone	15,24	CYP2B6	39,45	Methadone	CYP2B6	MESH:D008691	1555	Chemical	Gene	Metabolism|compound|START_ENTITY Differences|nmod|Metabolism Differences|nmod|Variants Variants|compound|END_ENTITY	Differences in Methadone Metabolism by CYP2B6 Variants .
26389554	0	Methadone	0,9	CYP2B6	28,34	Methadone	CYP2B6	MESH:D008691	1555	Chemical	Gene	Pharmacogenetics|compound|START_ENTITY Pharmacogenetics|dep|Concentrations Concentrations|compound|END_ENTITY	Methadone Pharmacogenetics : CYP2B6 Polymorphisms Determine Plasma Concentrations , Clearance , and Metabolism .
27010727	0	Methadone	37,46	CYP2B6	122,128	Methadone	CYP2B6	MESH:D008691	1555	Chemical	Gene	Treatment|compound|START_ENTITY Study|nmod|Treatment Identifies|nsubj|Study Identifies|dobj|rs17180299 rs17180299|nmod|SPON1 SPON1|compound|END_ENTITY	Genome-Wide Pharmacogenomic Study on Methadone Maintenance Treatment Identifies SNP rs17180299 and Multiple Haplotypes on CYP2B6 , SPON1 , and GSG1L Associated with Plasma Concentrations of Methadone_R - and S-enantiomers in Heroin-Dependent Patients .
22092298	0	Methadone	0,9	CYP2D6	19,25	Methadone	CYP2D6	MESH:D008691	1565	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Methadone inhibits CYP2D6 and UGT2B7/2B4 in vivo : a study using codeine in methadone - and buprenorphine-maintained subjects .
19520773	0	Methadone	0,9	pregnane_X_receptor	96,115	Methadone	pregnane X receptor	MESH:D008691	8856	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Methadone induces the expression of hepatic drug-metabolizing enzymes through the activation of pregnane_X_receptor and constitutive_androstane_receptor .
22166834	0	Methallyl_isothiocyanate	0,24	caspase-1	38,47	Methallyl isothiocyanate	caspase-1	null	834	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Methallyl_isothiocyanate inhibits the caspase-1 activity through the inhibition of intracellular calcium levels .
19945523	0	Methamphetamine	0,15	IL-1beta	58,66	Methamphetamine	IL-1beta	MESH:D008694	3553	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Methamphetamine cytotoxicity and effect on LPS-stimulated IL-1beta production by human monocytes .
22479453	0	Methamphetamine	0,15	IL-8	53,57	Methamphetamine	IL-8	MESH:D008694	3576	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Methamphetamine increases LPS-mediated expression of IL-8 , TNF-a and IL-1b in human macrophages through common signaling pathways .
24603327	0	Methamphetamine	0,15	Kappa_opioid_receptor	114,135	Methamphetamine	Kappa opioid receptor	MESH:D008694	4986	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Methamphetamine induces autophagy as a pro-survival response against apoptotic endothelial cell death through the Kappa_opioid_receptor .
26023064	0	Methamphetamine	23,38	Relaxin-3	82,91	Methamphetamine	Relaxin-3	MESH:D008694	212108(Tax:10090)	Chemical	Gene	Administration|compound|START_ENTITY Administration|nmod|END_ENTITY	Sensitivity to Chronic Methamphetamine Administration and Withdrawal in Mice with Relaxin-3 / RXFP3 Deficiency .
26023064	0	Methamphetamine	23,38	Relaxin-3	82,91	Methamphetamine	Relaxin-3	MESH:D008694	212108(Tax:10090)	Chemical	Gene	Administration|compound|START_ENTITY Administration|nmod|END_ENTITY	Sensitivity to Chronic Methamphetamine Administration and Withdrawal in Mice with Relaxin-3 / RXFP3 Deficiency .
26302754	0	Methamphetamine	0,15	TAAR1	59,64	Methamphetamine	TAAR1	MESH:D008694	134864	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|appos|END_ENTITY	Methamphetamine induces trace_amine-associated_receptor_1 -LRB- TAAR1 -RRB- expression in human T lymphocytes : role in immunomodulation .
25740289	0	Methamphetamine	48,63	Trace_Amine-Associated_Receptor_1	0,33	Methamphetamine	Trace Amine-Associated Receptor 1	MESH:D008694	111174(Tax:10090)	Chemical	Gene	Intake|compound|START_ENTITY Regulation|nmod|Intake Regulation|compound|END_ENTITY	Trace_Amine-Associated_Receptor_1 Regulation of Methamphetamine Intake and Related Traits .
25746685	0	Methamphetamine	78,93	Vesicular_Monoamine_Transporter_2	10,43	Methamphetamine	Vesicular Monoamine Transporter 2	MESH:D008694	214084(Tax:10090)	Chemical	Gene	Toxicity|compound|START_ENTITY Protects|nmod|Toxicity Protects|nsubj|END_ENTITY	Increased Vesicular_Monoamine_Transporter_2 -LRB- VMAT2 ; Slc18a2 -RRB- Protects against Methamphetamine Toxicity .
9795171	0	Methamphetamine	0,15	fos	24,27	Methamphetamine	fos	MESH:D008694	314322(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Methamphetamine induces fos expression in the striatum and the substantia nigra pars reticulata in a rat model of Parkinson 's _ disease .
19576919	0	Methamphetamine	0,15	heme_oxygenase-1	24,40	Methamphetamine	heme oxygenase-1	MESH:D008694	3162	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Methamphetamine induces heme_oxygenase-1 expression in cortical neurons and glia to prevent its toxicity .
8866720	0	Methamphetamine	0,15	neuropeptide_Y	42,56	Methamphetamine	neuropeptide Y	MESH:D008694	24604(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|nmod|END_ENTITY	Methamphetamine stimulates the release of neuropeptide_Y and noradrenaline from the paraventricular nucleus in rats .
21435178	0	Methamphetamine	0,15	occludin	23,31	Methamphetamine	occludin	MESH:D008694	100506658	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|expression expression|compound|END_ENTITY	Methamphetamine alters occludin expression via NADPH oxidase-induced oxidative insult and intact caveolae .
9988101	0	Methamphetamine	0,15	prodynorphin	23,35	Methamphetamine	prodynorphin	MESH:D008694	29190(Tax:10116)	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|expression expression|amod|END_ENTITY	Methamphetamine alters prodynorphin gene expression and dynorphin_A levels in rat hypothalamus .
26302754	0	Methamphetamine	0,15	trace_amine-associated_receptor_1	24,57	Methamphetamine	trace amine-associated receptor 1	MESH:D008694	134864	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Methamphetamine induces trace_amine-associated_receptor_1 -LRB- TAAR1 -RRB- expression in human T lymphocytes : role in immunomodulation .
17959316	0	Methamphetamine	0,15	tyrosine_hydroxylase	46,66	Methamphetamine	tyrosine hydroxylase	MESH:D008694	7054	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Methamphetamine induces ectopic expression of tyrosine_hydroxylase and increases noradrenaline levels within the cerebellar cortex .
12958151	0	Methanandamide	0,14	COX-2	25,30	Methanandamide	COX-2	MESH:C088155	17709(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Methanandamide increases COX-2 expression and tumor growth in murine lung_cancer .
26372346	0	Methane	5,12	Sink	13,17	Methane	Sink	MESH:D008697	57761	Chemical	Gene	Response|compound|START_ENTITY Response|compound|END_ENTITY	Soil Methane Sink Capacity Response to a Long-Term Wildfire Chronosequence in Northern Sweden .
15748872	0	Methanesulfonyl_fluoride	0,24	acetylcholinesterase	29,49	Methanesulfonyl fluoride	acetylcholinesterase	MESH:C005109	83817(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Methanesulfonyl_fluoride , an acetylcholinesterase inhibitor , attenuates simple learning and memory_deficits in ischemic rats .
17911406	0	Methimazole	0,11	CXC_chemokine_ligand_10	21,44	Methimazole	CXC chemokine ligand 10	MESH:D008713	3627	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|amod|END_ENTITY	Methimazole inhibits CXC_chemokine_ligand_10 secretion in human thyrocytes .
1794603	0	Methimazole	0,11	thyroglobulin	42,55	Methimazole	thyroglobulin	MESH:D008713	24826(Tax:10116)	Chemical	Gene	increase|amod|START_ENTITY END_ENTITY|nsubj|increase	Methimazole and propylthiouracil increase thyroglobulin gene expression in FRTL-5 cells .
25759391	0	Methionine	25,35	Apolipoprotein_A-I	84,102	Methionine	Apolipoprotein A-I	MESH:D008715	335	Chemical	Gene	Oxidation|compound|START_ENTITY Promotes|nsubj|Oxidation Promotes|dobj|Outcome Outcome|nmod|END_ENTITY	Myeloperoxidase-mediated Methionine Oxidation Promotes an Amyloidogenic Outcome for Apolipoprotein_A-I .
18719109	0	Methionine	0,10	apolipoprotein_A-I	62,80	Methionine	apolipoprotein A-I	MESH:D008715	335	Chemical	Gene	oxidation|compound|START_ENTITY impairs|nsubj|oxidation impairs|nmod|END_ENTITY	Methionine oxidation impairs reverse cholesterol transport by apolipoprotein_A-I .
20133843	0	Methionine	0,10	apolipoprotein_A-I	69,87	Methionine	apolipoprotein A-I	MESH:D008715	335	Chemical	Gene	oxidation|compound|START_ENTITY induces|nsubj|oxidation induces|nmod|END_ENTITY	Methionine oxidation induces amyloid fibril formation by full-length apolipoprotein_A-I .
6131372	0	Methionine	0,10	enkephalin	52,62	Methionine	enkephalin	MESH:D008715	29237(Tax:10116)	Chemical	Gene	oxidation|compound|START_ENTITY enhances|nsubj|oxidation enhances|dobj|activity activity|nmod|analog analog|compound|END_ENTITY	Methionine oxidation enhances opioid activity of an enkephalin analog .
11606777	0	Methionine_sulfoxide	0,20	MsrA	32,36	Methionine sulfoxide	MsrA	MESH:C013111	110265(Tax:10090)	Chemical	Gene	reductase|amod|START_ENTITY reductase|appos|END_ENTITY	Methionine_sulfoxide reductase -LRB- MsrA -RRB- is a regulator of antioxidant defense and lifespan in mammals .
19733220	0	Methionine_sulfoxide	0,20	MsrA	34,38	Methionine sulfoxide	MsrA	MESH:C013111	110265(Tax:10090)	Chemical	Gene	A|compound|START_ENTITY A|appos|END_ENTITY	Methionine_sulfoxide reductase A -LRB- MsrA -RRB- restores alpha-crystallin chaperone activity lost upon methionine oxidation .
20506347	0	Methionine_sulfoxide	0,20	MsrA	34,38	Methionine sulfoxide	MsrA	MESH:C013111	110265(Tax:10090)	Chemical	Gene	A|compound|START_ENTITY A|appos|END_ENTITY	Methionine_sulfoxide reductase A -LRB- MsrA -RRB- protects cultured mouse embryonic stem cells from H2O2-mediated oxidative stress .
26117066	0	Methionine_sulfoxide	0,20	MsrA	34,38	Methionine sulfoxide	MsrA	MESH:C013111	4482	Chemical	Gene	A|compound|START_ENTITY A|appos|END_ENTITY	Methionine_sulfoxide reductase A -LRB- MsrA -RRB- associated with bipolar_I_disorder and executive functions in A Han Chinese population .
26786779	0	Methionine_sulfoxide	0,20	MsrA	34,38	Methionine sulfoxide	MsrA	MESH:C013111	110265(Tax:10090)	Chemical	Gene	A|compound|START_ENTITY A|appos|END_ENTITY	Methionine_sulfoxide reductase A -LRB- MsrA -RRB- affects beta-amyloid solubility and mitochondrial function in a mouse model of Alzheimer 's _ disease .
16666918	0	Methomyl	40,48	Heat_Shock_Protein	0,18	Methomyl	Heat Shock Protein	MESH:D008724	100286241(Tax:4577)	Chemical	Gene	Induced|nmod|START_ENTITY Induced|compound|END_ENTITY	Heat_Shock_Protein Synthesis Induced by Methomyl in Maize -LRB- Zea_mays_L . -RRB-
26783755	0	Methotrexate	41,53	Ceramide_Synthase_6	0,19	Methotrexate	Ceramide Synthase 6	MESH:D008727	253782	Chemical	Gene	Target|nmod|START_ENTITY Target|nsubj|END_ENTITY	Ceramide_Synthase_6 Is a Novel Target of Methotrexate Mediating Its Antiproliferative Effect in a p53-Dependent Manner .
20026300	1	Methotrexate	100,112	DHFR	149,153	Methotrexate	HDAC	MESH:D008727	9734	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|appos|END_ENTITY	Methotrexate -LRB- MTX -RRB- is a dihydrofolate_reductase -LRB- DHFR -RRB- inhibitor widely used for treating human cancers , and overexpression of histone_deacetylase -LRB- HDAC -RRB- is usually found in tumors .
8111032	0	Methotrexate	0,12	DHFR	40,44	Methotrexate	DHFR	MESH:D008727	13361(Tax:10090)	Chemical	Gene	block|nsubj|START_ENTITY block|dobj|import import|nmod|protein protein|amod|END_ENTITY	Methotrexate does not block import of a DHFR fusion protein into chloroplasts .
26242737	0	Methotrexate	73,85	Dihydrofolate_Reductase	0,23	Methotrexate	Dihydrofolate Reductase	MESH:D008727	1719	Chemical	Gene	Interact|compound|START_ENTITY Transgenes|nmod|Interact Transgenes|nsubj|END_ENTITY	Dihydrofolate_Reductase and Thymidylate_Synthase Transgenes Resistant to Methotrexate Interact to Permit Novel Transgene Regulation .
26242737	0	Methotrexate	73,85	Dihydrofolate_Reductase	0,23	Methotrexate	Dihydrofolate Reductase	MESH:D008727	1719	Chemical	Gene	Interact|compound|START_ENTITY Transgenes|nmod|Interact Transgenes|nsubj|END_ENTITY	Dihydrofolate_Reductase and Thymidylate_Synthase Transgenes Resistant to Methotrexate Interact to Permit Novel Transgene Regulation .
22778921	0	Methotrexate	0,12	GLUT4	39,44	Methotrexate	GLUT4	MESH:D008727	20528(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|Expression Expression|compound|END_ENTITY	Methotrexate Increases Skeletal Muscle GLUT4 Expression and Improves Metabolic Control in Experimental Diabetes .
9777700	0	Methotrexate	0,12	ICAM-1	23,29	Methotrexate	ICAM-1	MESH:D008727	25464(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Methotrexate regulates ICAM-1 expression in recipients of rat cardiac allografts .
24444433	0	Methotrexate	0,12	IL-1	35,39	Methotrexate	IL-1	MESH:D008727	3552	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|nmod|END_ENTITY	Methotrexate induces production of IL-1 and IL-6 in the monocytic cell line U937 .
22197938	0	Methotrexate	0,12	MEK	54,57	Methotrexate	MEK	MESH:D008727	5609	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	Methotrexate modulates tight junctions through NF-kB , MEK , and JNK pathways .
10852985	0	Methotrexate	0,12	cyclooxygenase_2	31,47	Methotrexate	cyclooxygenase 2	MESH:D008727	5743	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|amod|END_ENTITY	Methotrexate as a preferential cyclooxygenase_2 inhibitor in whole blood of patients with rheumatoid_arthritis .
11896448	0	Methotrexate	0,12	dihydrofolate_reductase	146,169	Methotrexate	dihydrofolate reductase	MESH:D008727	1719	Chemical	Gene	selection|amod|START_ENTITY selection|nmod|retrovirus retrovirus|acl|containing containing|dobj|gene gene|compound|END_ENTITY	Methotrexate selection of long-term culture initiating cells following transduction of CD34 -LRB- + -RRB- cells with a retrovirus containing a mutated human dihydrofolate_reductase gene .
15857949	0	Methotrexate	0,12	dihydrofolate_reductase	144,167	Methotrexate	dihydrofolate reductase	MESH:D008727	13361(Tax:10090)	Chemical	Gene	preconditioning|amod|START_ENTITY allows|nsubj|preconditioning allows|dobj|engraftment engraftment|acl|confer confer|nmod|mice mice|dep|expressing expressing|dobj|activity activity|compound|END_ENTITY	Methotrexate preconditioning allows sufficient engraftment to confer drug resistance in mice transplanted with marrow expressing drug-resistant dihydrofolate_reductase activity .
19337845	0	Methotrexate	113,125	dihydrofolate_reductase	78,101	Methotrexate	dihydrofolate reductase	MESH:D008727	42003(Tax:7227)	Chemical	Gene	resistance|amod|START_ENTITY Selection|dep|resistance Selection|nmod|resistance resistance|nmod|cells cells|acl|bearing bearing|dobj|transgene transgene|compound|END_ENTITY	Selection for methotrexate resistance in mammalian cells bearing a Drosophila dihydrofolate_reductase transgene : Methotrexate resistance in transgenic mammalian cells .
2044765	0	Methotrexate	0,12	dihydrofolate_reductase	60,83	Methotrexate	dihydrofolate reductase	MESH:D008727	1719	Chemical	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Methotrexate binds in a non-productive orientation to human dihydrofolate_reductase in solution , based on NMR spectroscopy .
21468213	0	Methotrexate	0,12	dihydrofolate_reductase	108,131	Methotrexate	dihydrofolate reductase	MESH:D008727	1719	Chemical	Gene	supports|nsubj|START_ENTITY supports|advcl|expressing expressing|dobj|END_ENTITY	Methotrexate supports in vivo selection of human embryonic stem cell derived-hematopoietic cells expressing dihydrofolate_reductase .
2436625	0	Methotrexate	0,12	dihydrofolate_reductase	70,93	Methotrexate	dihydrofolate reductase	MESH:D008727	100689028	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|acl|lacking lacking|dobj|END_ENTITY	Methotrexate metabolism in mutant Chinese_hamster ovary cells lacking dihydrofolate_reductase .
7713922	0	Methotrexate	0,12	dihydrofolate_reductase	37,60	Methotrexate	dihydrofolate reductase	MESH:D008727	1719	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|proteolysis proteolysis|nmod|END_ENTITY	Methotrexate inhibits proteolysis of dihydrofolate_reductase by the N-end rule pathway .
8265628	0	Methotrexate	0,12	dihydrofolate_reductase	75,98	Methotrexate	dihydrofolate reductase	MESH:D008727	13361(Tax:10090)	Chemical	Gene	resistance|amod|START_ENTITY resistance|amod|due due|nmod|mutation mutation|compound|END_ENTITY	Methotrexate resistance in an in vivo mouse tumor due to a non-active-site dihydrofolate_reductase mutation .
25239859	0	Methotrexate	31,43	hOAT3	101,106	Methotrexate	hOAT3	MESH:D008727	9376	Chemical	Gene	Transport|compound|START_ENTITY Transport|nmod|END_ENTITY	Proton Pump Inhibitors Inhibit Methotrexate Transport by Renal Basolateral Organic Anion Transporter hOAT3 .
10708808	0	Methotrexate	0,12	interleukin-6	28,41	Methotrexate	interleukin-6	MESH:D008727	3569	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|generation generation|amod|END_ENTITY	Methotrexate suppresses the interleukin-6 induced generation of reactive oxygen species in the synoviocytes of rheumatoid_arthritis .
12739045	0	Methotrexate	0,12	interleukin-6	22,35	Methotrexate	interleukin-6	MESH:D008727	3569	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Methotrexate inhibits interleukin-6 production in patients with juvenile_rheumatoid_arthritis .
15868610	0	Methotrexate	0,12	interleukin_6	53,66	Methotrexate	interleukin 6	MESH:D008727	16193(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|agonist agonist|acl|induced induced|dobj|synthesis synthesis|amod|END_ENTITY	Methotrexate suppresses inflammatory agonist induced interleukin_6 synthesis in osteoblasts .
23660772	0	Methotrexate	0,12	thiopurine_S-methyltransferase	34,64	Methotrexate	thiopurine S-methyltransferase	MESH:D008727	7172	Chemical	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Methotrexate binds to recombinant thiopurine_S-methyltransferase and inhibits enzyme activity after high-dose infusions in childhood leukaemia .
9889412	0	Methotrexate	0,12	tumor_necrosis_factor	34,55	Methotrexate	tumor necrosis factor	MESH:D008727	21926(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	Methotrexate inhibits LPS-induced tumor_necrosis_factor production in vivo .
9973187	0	Methoxyresorufin	0,16	CYP1A2	49,55	Methoxyresorufin	CYP1A2	null	13077(Tax:10090)	Chemical	Gene	START_ENTITY|dep|substrate substrate|nmod|END_ENTITY	Methoxyresorufin : an inappropriate substrate for CYP1A2 in the mouse .
16530985	2	Methyl	369,375	MECP2	271,276	Methyl	MeCP2	CHEBI:32875	4204	Chemical	Gene	Domain|compound|START_ENTITY sharing|dobj|Domain codifying|advcl|sharing mutations|acl|codifying mutations|nmod|gene gene|compound|END_ENTITY	It is associated with mutations of the MECP2 gene , codifying for a methyl-CpG DNA_binding_protein of the MBDs family , sharing the common Methyl Binding Domain .
12949043	0	Methyl	0,6	MeCP2	70,75	Methyl	MeCP2	CHEBI:32875	29386(Tax:10116)	Chemical	Gene	deficiency|amod|START_ENTITY causes|nsubj|deficiency causes|dobj|reduction reduction|nmod|protein protein|appos|END_ENTITY	Methyl deficiency causes reduction of the methyl-CpG-binding protein , MeCP2 , in rat liver .
26596603	0	Methyl	79,85	SN2	75,78	Methyl	SN2	CHEBI:32875	92745	Chemical	Gene	Transfer|compound|START_ENTITY Transfer|compound|END_ENTITY	Kinetic Isotope Effects from QM/MM Subset Hessians : `` Cut-Off '' Analysis for SN2 Methyl Transfer in Solution .
26699931	0	Methyl-Parathion	70,86	StAR	15,19	Methyl-Parathion	StAR	MESH:D008743	63999(Tax:7955)	Chemical	Gene	exposed|nmod|START_ENTITY exposed|nsubj|END_ENTITY	Impaired brain StAR and HSP70 gene expression in zebrafish exposed to Methyl-Parathion based insecticide .
18478239	0	Methyl-beta-cyclodextrin	0,24	ERK	130,133	Methyl-beta-cyclodextrin	ERK	MESH:C108732	5594	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|activation activation|nmod|END_ENTITY	Methyl-beta-cyclodextrin , a specific cholesterol-binding agent , inhibits melanogenesis in human melanocytes through activation of ERK .
15262974	7	Methyl-beta-cyclodextrin	1328,1352	p38	1375,1378	Methyl-beta-cyclodextrin	p38	MESH:C108732	1432	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Methyl-beta-cyclodextrin induces activation of p38 and Cdc42 , but not Rac , in the nonstimulated PMN , yet inhibits subsequent lipopolysaccharide-induced activation of p38 and Cdc42 .
25579386	0	Methyl_CpG	74,84	Brain-Derived_Neurotrophic_Factor	30,63	Methyl CpG	Brain-Derived Neurotrophic Factor	null	627	Chemical	Gene	Protein|compound|START_ENTITY END_ENTITY|nmod|Protein	Transcriptional Regulation of Brain-Derived_Neurotrophic_Factor -LRB- BDNF -RRB- by Methyl_CpG Binding Protein 2 -LRB- MeCP2 -RRB- : a Novel Mechanism for Re-Myelination and/or Myelin Repair Involved in the Treatment of Multiple_Sclerosis -LRB- MS -RRB- .
25579386	0	Methyl_CpG	74,84	MeCP2	104,109	Methyl CpG	MeCP2	null	4204	Chemical	Gene	Protein|compound|START_ENTITY Protein|appos|END_ENTITY	Transcriptional Regulation of Brain-Derived_Neurotrophic_Factor -LRB- BDNF -RRB- by Methyl_CpG Binding Protein 2 -LRB- MeCP2 -RRB- : a Novel Mechanism for Re-Myelination and/or Myelin Repair Involved in the Treatment of Multiple_Sclerosis -LRB- MS -RRB- .
4082198	0	Methyl_ethyl_ketone_peroxide	0,28	cytochrome_P-450	39,55	Methyl ethyl ketone peroxide	cytochrome P-450	MESH:C011007	25251(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activities activities|amod|END_ENTITY	Methyl_ethyl_ketone_peroxide damage to cytochrome_P-450 peroxidase activities .
9297848	0	Methyl_jasmonate	0,16	O-methyltransferase	28,47	Methyl jasmonate	O-methyltransferase	MESH:C072239	548265(Tax:4513)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Methyl_jasmonate induces an O-methyltransferase in barley .
18525316	0	Methyl_jasmonate	0,16	proliferating_cell_nuclear_antigen	45,79	Methyl jasmonate	proliferating cell nuclear antigen	MESH:C072239	5111	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|nmod|END_ENTITY	Methyl_jasmonate downregulates expression of proliferating_cell_nuclear_antigen and induces apoptosis in human neuroblastoma cell lines .
19029078	0	Methyl_methacrylate	0,19	Gsta1	34,39	Methyl methacrylate	Gsta1	MESH:D020366	2938	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|promoter promoter|amod|END_ENTITY	Methyl_methacrylate activates the Gsta1 promoter .
8222061	0	Methyl_methanesulfonate	0,23	DHFR	59,63	Methyl methanesulfonate	DHFR	MESH:D008741	100689028	Chemical	Gene	START_ENTITY|nmod|gene gene|amod|END_ENTITY	Methyl_methanesulfonate adduct formation and repair in the DHFR gene and in mitochondrial DNA in hamster cells .
23117069	0	Methyl_methanesulfonate	0,23	caspase_2	91,100	Methyl methanesulfonate	caspase 2	MESH:D008741	835	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|pathway pathway|amod|END_ENTITY	Methyl_methanesulfonate induces apoptosis in p53-deficient H1299 and Hep3B cells through a caspase_2 - and mitochondria-associated pathway .
25733328	0	Methyl_protodioscin	0,19	ABCA1	30,35	Methyl protodioscin	ABCA1	MESH:C425324	19	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Methyl_protodioscin increases ABCA1 expression and cholesterol efflux while inhibiting gene expressions for synthesis of cholesterol and triglycerides by suppressing SREBP transcription and microRNA 33a/b levels .
19091749	0	Methylalpinumisoflavone	0,23	hypoxia-inducible_factor-1	33,59	Methylalpinumisoflavone	hypoxia-inducible factor-1	null	3091	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	Methylalpinumisoflavone inhibits hypoxia-inducible_factor-1 -LRB- HIF-1 -RRB- activation by simultaneously targeting multiple pathways .
1631902	0	Methylamine	0,11	semicarbazide-sensitive_amine_oxidase	51,88	Methylamine	semicarbazide-sensitive amine oxidase	MESH:C027451	29473(Tax:10116)	Chemical	Gene	metabolism|nsubj|START_ENTITY metabolism|nmod|END_ENTITY	Methylamine metabolism to formaldehyde by vascular semicarbazide-sensitive_amine_oxidase .
10693175	0	Methylcobalamin	0,15	androgen-induced_growth_factor	41,71	Methylcobalamin	androgen-induced growth factor	MESH:C019476	2253	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|levels levels|nmod|END_ENTITY	Methylcobalamin decreases mRNA levels of androgen-induced_growth_factor in androgen-dependent Shionogi_carcinoma 115 cells .
26941101	0	Methylene_Blue	45,59	MEF2D	0,5	Methylene Blue	MEF2D	MESH:D008751	17261(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Mediates|dobj|Effect Mediates|nsubj|END_ENTITY	MEF2D Mediates the Neuroprotective Effect of Methylene_Blue Against Glutamate-Induced Oxidative Damage in HT22 Hippocampal Cells .
25736558	0	Methylene_Blue	0,14	iNOS	26,30	Methylene Blue	iNOS	MESH:D008751	18126(Tax:10090)	Chemical	Gene	Attenuates|compound|START_ENTITY END_ENTITY|nsubj|Attenuates	Methylene_Blue Attenuates iNOS Induction Through Suppression of Transcriptional Factor Binding Amid iNOS mRNA Transcription .
25766590	0	Methylene_Tetrahydrofolate	52,78	Mthfr	90,95	Methylene Tetrahydrofolate	Mthfr	CHEBI:25297	17769(Tax:10090)	Chemical	Gene	Reductase|compound|START_ENTITY Reductase|appos|END_ENTITY	Retinal_Ganglion_Cell_Loss_and_Mild_Vasculopathy in Methylene_Tetrahydrofolate Reductase -LRB- Mthfr -RRB- - Deficient Mice : A Model of Mild Hyperhomocysteinemia .
10781649	0	Methylene_tetrahydrofolate	0,26	MTHFR	38,43	Methylene tetrahydrofolate	MTHFR	CHEBI:25297	4524	Chemical	Gene	reductase|amod|START_ENTITY reductase|appos|END_ENTITY	Methylene_tetrahydrofolate reductase -LRB- MTHFR -RRB- and nitric_oxide synthase -LRB- ecNOS -RRB- genes and risks of peripheral_arterial_disease and coronary_heart_disease : Edinburgh Artery Study .
24338216	0	Methylene_tetrahydrofolate	0,26	MTHFR	38,43	Methylene tetrahydrofolate	MTHFR	CHEBI:25297	4524	Chemical	Gene	polymorphisms|amod|START_ENTITY polymorphisms|appos|END_ENTITY	Methylene_tetrahydrofolate reductase -LRB- MTHFR -RRB- gene polymorphisms in chronic_myeloid_leukemia : an Egyptian study .
12008053	1	Methyleneaminoxymethyl	85,107	cyclooxygenase-2	148,164	Methyleneaminoxymethyl	cyclooxygenase-2	null	5743	Chemical	Gene	analogues|amod|START_ENTITY analogues|nmod|inhibitors inhibitors|amod|END_ENTITY	Methyleneaminoxymethyl -LRB- MAOM -RRB- analogues of diarylcyclopentenyl cyclooxygenase-2 inhibitors : synthesis and biological properties .
20077113	0	Methylglyoxal	0,13	Gcn2	24,28	Methylglyoxal	Gcn2	MESH:D011765	851877(Tax:4932)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Methylglyoxal activates Gcn2 to phosphorylate eIF2alpha independently of the TOR pathway in Saccharomyces_cerevisiae .
26965039	0	Methylglyoxal	0,13	Insulin	69,76	Methylglyoxal	Insulin	MESH:D011765	3630	Chemical	Gene	Associated|nsubj|START_ENTITY Associated|nmod|Resistance Resistance|compound|END_ENTITY	Methylglyoxal , A Metabolite Increased in Diabetes is Associated with Insulin Resistance , Vascular Dysfunction and Neuropathies .
11707430	0	Methylglyoxal	0,13	protein_kinase_Cdelta	68,89	Methylglyoxal	protein kinase Cdelta	MESH:D011765	5580	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|advcl|activating activating|dobj|END_ENTITY	Methylglyoxal enhances cisplatin-induced cytotoxicity by activating protein_kinase_Cdelta .
22740698	0	Methylglyoxal	0,13	transient_receptor_potential_channel_A1	44,83	Methylglyoxal	transient receptor potential channel A1	MESH:D011765	8989	Chemical	Gene	activates|nsubj|START_ENTITY activates|nmod|END_ENTITY	Methylglyoxal activates nociceptors through transient_receptor_potential_channel_A1 -LRB- TRPA1 -RRB- : a possible mechanism of metabolic neuropathies .
17152979	0	Methylketone	0,12	plasmin	27,34	Methylketone	plasmin	CHEBI:15347	5340	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Methylketone inhibitors of plasmin .
23208443	0	Methylmercury	0,13	CCL2	22,26	Methylmercury	CCL2	CHEBI:30785	6347	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Methylmercury induces CCL2 expression through activation of NF-kB in human 1321N1 astrocytes .
12644250	0	Methylmercury	0,13	TrkA	36,40	Methylmercury	TrkA	CHEBI:30785	59109(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|autophosphorylation autophosphorylation|compound|END_ENTITY	Methylmercury decreases NGF-induced TrkA autophosphorylation and neurite outgrowth in PC12 cells .
15013629	0	Methylmercury	0,13	TrkA	23,27	Methylmercury	TrkA	CHEBI:30785	59109(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Methylmercury inhibits TrkA signaling through the ERK1/2 cascade after NGF stimulation of PC12 cells .
25545984	0	Methylmercury	0,13	TrkA	72,76	Methylmercury	TrkA	CHEBI:30785	59109(Tax:10116)	Chemical	Gene	causes|nsubj|START_ENTITY causes|nmod|suppression suppression|nmod|pathway pathway|compound|END_ENTITY	Methylmercury causes neuronal cell death through the suppression of the TrkA pathway : In vitro and in vivo effects of TrkA pathway activators .
26108095	0	Methylmercury	0,13	prolactin	23,32	Methylmercury	prolactin	CHEBI:30785	5617	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|compound|END_ENTITY	Methylmercury inhibits prolactin release in a cell line of pituitary origin .
25817856	0	Methylphenidate	80,95	Dopamine_Transporter	112,132	Methylphenidate	Dopamine Transporter	MESH:D008774	13162(Tax:10090)	Chemical	Gene	Cortex|nmod|START_ENTITY Level|nmod|Cortex Improvement|nmod|Level Improvement|nmod|END_ENTITY	Improvement of Learning and Increase in Dopamine Level in the Frontal Cortex by Methylphenidate in Mice Lacking Dopamine_Transporter .
18514368	0	Methylphenidate	0,15	NCS-1	23,28	Methylphenidate	NCS-1	MESH:D008774	65153(Tax:10116)	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|expression expression|compound|END_ENTITY	Methylphenidate alters NCS-1 expression in rat brain .
15862622	0	Methylphenidate	0,15	c-fos	26,31	Methylphenidate	c-fos	MESH:D008774	314322(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Methylphenidate regulates c-fos and fosB expression in multiple regions of the immature rat brain .
15916815	0	Methylphenidate	0,15	c-fos	41,46	Methylphenidate	c-fos	MESH:D008774	314322(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Methylphenidate differentially regulates c-fos and fosB expression in the developing rat striatum .
12141399	0	Methylphenidate	0,15	cytochrome_P450	25,40	Methylphenidate	cytochrome P450	MESH:D008774	13079(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Methylphenidate inhibits cytochrome_P450 in the Swiss Webster mouse .
15945061	0	Methylphenidate	0,15	dopamine_transporter	103,123	Methylphenidate	dopamine transporter	MESH:D008774	24898(Tax:10116)	Chemical	Gene	analogs|amod|START_ENTITY interact|nsubj|analogs interact|nmod|END_ENTITY	Methylphenidate analogs with behavioral differences interact differently with arginine residues on the dopamine_transporter in rat striatum .
20211696	0	Methylphenidate	0,15	dopamine_transporter	36,56	Methylphenidate	dopamine transporter	MESH:D008774	24898(Tax:10116)	Chemical	Gene	normalizes|amod|START_ENTITY elevated|nsubj|normalizes elevated|dobj|densities densities|compound|END_ENTITY	Methylphenidate normalizes elevated dopamine_transporter densities in an animal model of the attention-deficit/hyperactivity _ disorder combined type , but not to the same extent in one of the attention-deficit/hyperactivity _ disorder inattentive type .
977729	0	Methylphenidate	0,15	growth_hormone	32,46	Methylphenidate	growth hormone	MESH:D008774	2688	Chemical	Gene	increases|amod|START_ENTITY serum|nsubj|increases serum|dobj|concentrations concentrations|amod|END_ENTITY	Methylphenidate increases serum growth_hormone concentrations .
26485919	0	Methylprednisolone	62,80	BDNF	105,109	Methylprednisolone	BDNF	MESH:D008775	24225(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|Levels Levels|nmod|END_ENTITY	-LSB- Effect of Herba Lycopodii Alcohol Extracted Granule Combined Methylprednisolone on Expression Levels of BDNF and NMDA and Behavior of Traumatic Spinal_Cord_Injury Rats -RSB- .
20003332	0	Methylprednisolone	0,18	IFN-gamma	28,37	Methylprednisolone	IFN-gamma	MESH:D008775	25712(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Methylprednisolone inhibits IFN-gamma and IL-17 expression and production by cells infiltrating central nervous system in experimental_autoimmune_encephalomyelitis .
8870704	0	Methylprednisolone	0,18	IL-10	44,49	Methylprednisolone	IL-10	MESH:D008775	16153(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|amod|END_ENTITY	Methylprednisolone differentially regulates IL-10 and tumour_necrosis_factor -LRB- TNF -RRB- production during murine endotoxaemia .
25206681	0	Methylprednisolone	0,18	Nogo-A	28,34	Methylprednisolone	Nogo-A	MESH:D008775	83765(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Methylprednisolone inhibits Nogo-A protein expression after acute spinal_cord_injury .
8870704	0	Methylprednisolone	0,18	TNF	78,81	Methylprednisolone	TNF	MESH:D008775	21926(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|amod|IL-10 IL-10|dep|END_ENTITY	Methylprednisolone differentially regulates IL-10 and tumour_necrosis_factor -LRB- TNF -RRB- production during murine endotoxaemia .
9729336	0	Methylprednisolone	0,18	TNF-alpha	33,42	Methylprednisolone	TNF-alpha	MESH:D008775	24835(Tax:10116)	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|expression expression|amod|END_ENTITY	Methylprednisolone inhibition of TNF-alpha expression and NF-kB activation after spinal_cord_injury in rats .
2027030	0	Methylprednisolone	0,18	dystrophin	29,39	Methylprednisolone	dystrophin	MESH:D008775	1756	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|compound|END_ENTITY	Methylprednisolone increases dystrophin levels by inhibiting myotube_death during myogenesis of normal human muscle in vitro .
8437700	0	Methylprednisolone	0,18	dystrophin	39,49	Methylprednisolone	dystrophin	MESH:D008775	1756	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|expression expression|compound|END_ENTITY	Methylprednisolone selectively affects dystrophin expression in human muscle cultures .
10629165	0	Methylprednisolone	0,18	growth_hormone	51,65	Methylprednisolone	growth hormone	MESH:D008775	81668(Tax:10116)	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|release release|nmod|END_ENTITY	Methylprednisolone does not inhibit the release of growth_hormone after intravenous injection of a novel growth_hormone secretagogue in rats .
18700009	0	Methylprednisolone	0,18	interleukin-17	28,42	Methylprednisolone	interleukin-17	MESH:D008775	301289(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Methylprednisolone inhibits interleukin-17 and interferon-gamma expression by both naive and primed T cells .
10965934	0	Methylprednisolone	0,18	leptin	36,42	Methylprednisolone	leptin	MESH:D008775	3952	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|compound|END_ENTITY	Methylprednisolone increases plasma leptin levels in Graves ' hyperthyroidism patients with active Graves ' ophthalmopathy .
11393256	0	Methylprednisolone	0,18	tumor_necrosis_factor-alpha	72,99	Methylprednisolone	tumor necrosis factor-alpha	MESH:D008775	24835(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|advcl|affecting affecting|dobj|production production|amod|END_ENTITY	Methylprednisolone reduces spinal_cord_injury in rats without affecting tumor_necrosis_factor-alpha production .
26648017	0	Methylsulfonylmethane	0,21	HER2	31,35	Methylsulfonylmethane	HER2	MESH:C025910	2064	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Methylsulfonylmethane inhibits HER2 expression through STAT5b in breast_cancer cells .
22485142	0	Methylsulfonylmethane	0,21	STAT3	73,78	Methylsulfonylmethane	STAT3	MESH:C025910	6774	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	Methylsulfonylmethane suppresses breast_cancer growth by down-regulating STAT3 and STAT5b pathways .
26648017	0	Methylsulfonylmethane	0,21	STAT5b	55,61	Methylsulfonylmethane	STAT5b	MESH:C025910	6777	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Methylsulfonylmethane inhibits HER2 expression through STAT5b in breast_cancer cells .
24319502	0	Methylthiomorpholin_Phenols	19,46	Angiotensin-Converting_Enzyme	68,97	Methylthiomorpholin Phenols	Angiotensin-Converting Enzyme	null	1636	Chemical	Gene	Studies|nmod|START_ENTITY Studies|nmod|END_ENTITY	Docking Studies of Methylthiomorpholin_Phenols -LRB- LQM300 Series -RRB- with Angiotensin-Converting_Enzyme -LRB- ACE -RRB- .
117953	0	Metoclopramide	0,14	growth_hormone	38,52	Metoclopramide	growth hormone	MESH:D008787	2688	Chemical	Gene	stimulation|amod|START_ENTITY stimulation|dep|test test|nmod|reserve reserve|amod|END_ENTITY	Metoclopramide stimulation : a test of growth_hormone reserve in adolescent males .
519873	0	Metoclopramide	0,14	growth_hormone	23,37	Metoclopramide	growth hormone	MESH:D008787	2688	Chemical	Gene	induced|compound|START_ENTITY END_ENTITY|nsubj|induced	Metoclopramide induced growth_hormone release in hypogonadal males .
777023	0	Metoclopramide	0,14	prolactin	26,35	Metoclopramide	prolactin	MESH:D008787	5617	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|compound|END_ENTITY	Metoclopramide stimulates prolactin secretion in man .
3734042	0	Metoclopramide	0,14	vasopressin	25,36	Metoclopramide	vasopressin	MESH:D008787	551	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|secretion secretion|compound|END_ENTITY	Metoclopramide increases vasopressin secretion .
7542717	0	Metoprine	0,9	histamine_N-methyltransferase	27,56	Metoprine	histamine N-methyltransferase	MESH:C006308	81676(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Metoprine , an inhibitor of histamine_N-methyltransferase but not catechol-O-methyltransferase , suppresses feeding in sated and in food deprived rats .
14520486	0	Metoprolol	0,10	beta-1	14,20	Metoprolol	beta-1	MESH:D008790	3779	Chemical	Gene	START_ENTITY|appos|blocker blocker|amod|END_ENTITY	Metoprolol , a beta-1 selective blocker , can be used safely in coronary_artery_disease patients with chronic_obstructive_pulmonary_disease .
8820427	0	Metoprolol	0,10	cytochrome_P4502D6	26,44	Metoprolol	cytochrome P4502D6	MESH:D008790	1565	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|nmod|END_ENTITY	Metoprolol metabolism via cytochrome_P4502D6 in ethnic populations .
7027889	0	Metoprolol	0,10	renin	19,24	Metoprolol	renin	MESH:D008790	5972	Chemical	Gene	START_ENTITY|nmod|hypertension hypertension|compound|END_ENTITY	Metoprolol in high renin hypertension .
16687942	0	Metoprolol_succinate	0,20	insulin	76,83	Metoprolol succinate	insulin	MESH:C402833	3630	Chemical	Gene	has|nsubj|START_ENTITY has|dobj|effect effect|nmod|sensitivity sensitivity|compound|END_ENTITY	Metoprolol_succinate , a selective beta-adrenergic blocker , has no effect on insulin sensitivity .
8102782	0	Metrazole	0,9	c-fos	47,52	Metrazole	c-fos	MESH:D010433	314322(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|nmod|END_ENTITY	Metrazole induces the sequential activation of c-fos , proenkephalin , and tyrosine_hydroxylase gene expression in the rat adrenal gland : modulation by glucocorticoid and adrenocorticotropic hormone .
8255173	0	Metrazole	0,9	c-fos	23,28	Metrazole	c-fos	MESH:D010433	314322(Tax:10116)	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Metrazole induction of c-fos and proenkephalin gene expression in the rat adrenal and hippocampus : pharmacological characterization .
2174517	0	Metyrapone	0,10	beta-endorphin	22,36	Metyrapone	beta-endorphin	MESH:D008797	5443	Chemical	Gene	effects|nsubj|START_ENTITY effects|nmod|levels levels|amod|END_ENTITY	Metyrapone effects on beta-endorphin , ACTH and cortisol levels after chronic opiate receptor stimulation in man .
21304979	0	Mevalonate	0,10	p53	98,101	Mevalonate	p53	MESH:D008798	7157	Chemical	Gene	regulation|amod|START_ENTITY regulation|dep|role role|nmod|END_ENTITY	Mevalonate cascade regulation of airway mesenchymal cell autophagy and apoptosis : a dual role for p53 .
12947334	0	Mevastatin	0,10	THP-1	96,101	Mevastatin	THP-1	MESH:C012258	2736	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|activation activation|nmod|END_ENTITY	Mevastatin suppresses lipopolysaccharide-induced Rac activation in the human monocyte cell line THP-1 .
24197266	0	Mg	17,19	FCP	87,90	Mg	FCP	null	2221	Chemical	Gene	Influence|nmod|START_ENTITY END_ENTITY|nsubj|Influence	Influence of pH , Mg , and lipid composition on the aggregation state of the diatom FCP in comparison to the LHCII of vascular plants .
21199822	0	Mg	48,50	LiF	44,47	Mg	LiF	null	3976	Chemical	Gene	effect|dep|START_ENTITY effect|nmod|END_ENTITY	Pre - and post-irradiation fading effect for LiF : Mg , Ti and LiF : Mg , Cu , P materials used in routine monitoring .
26503857	0	Mg	21,23	LiF	17,20	Mg	LiF	D008274	3976	Chemical	Gene	EFFECT|dep|START_ENTITY EFFECT|nmod|END_ENTITY	FADING EFFECT OF LiF : Mg , Ti AND LiF : Mg , Cu , P Ext-Rad AND WHOLE-BODY DETECTORS .
26748081	0	Mg	16,18	MRS2-4	32,38	Mg	MRS2-4	D008274	825066(Tax:3702)	Chemical	Gene	Transporter|compound|START_ENTITY Transporter|appos|END_ENTITY	The Arabidopsis Mg Transporter , MRS2-4 , is Essential for Mg Homeostasis Under Both Low and High Mg Conditions .
26748081	0	Mg	57,59	MRS2-4	32,38	Mg	MRS2-4	D008274	825066(Tax:3702)	Chemical	Gene	Homeostasis|compound|START_ENTITY Essential|nmod|Homeostasis Essential|nsubj|Transporter Transporter|appos|END_ENTITY	The Arabidopsis Mg Transporter , MRS2-4 , is Essential for Mg Homeostasis Under Both Low and High Mg Conditions .
26748081	4	Mg	541,543	MRS2-4	530,536	Mg	MRS2-4	D008274	825066(Tax:3702)	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|appos|transporter	The causal gene of the mutant encodes MRS2-4 , an Mg transporter .
15709756	0	MgADP	182,187	MF1	213,216	MgADP	MF1	MESH:D000244	2237	Chemical	Gene	START_ENTITY|nmod|structures structures|nmod|END_ENTITY	The characteristics of the -LRB- alpha V371C -RRB- 3 -LRB- beta R337C -RRB- 3 gamma double mutant subcomplex of the TF1-ATPase indicate that the catalytic site at the alpha TP-beta TP interface with bound MgADP in crystal structures of MF1 represents a catalytic site containing inhibitory MgADP .
10722048	0	MgADP	21,26	myosin	30,36	MgADP	myosin	MESH:D000244	79784	Chemical	Gene	binding|nmod|START_ENTITY binding|nmod|END_ENTITY	Anomalous binding of MgADP to myosin of skeletal muscle .
8930391	0	MgATP	38,43	SNAP-25	16,23	MgATP	SNAP-25	MESH:D000255	6616	Chemical	Gene	Dissociation|nmod|START_ENTITY Dissociation|nmod|END_ENTITY	Dissociation of SNAP-25 and VAMP-2 by MgATP in permeabilized adrenal chromaffin cells .
6606429	0	MgATP	70,75	cholesterol_7_alpha-hydroxylase	35,66	MgATP	cholesterol 7 alpha-hydroxylase	MESH:D000255	25428(Tax:10116)	Chemical	Gene	microsomal|nmod|START_ENTITY microsomal|xcomp|END_ENTITY	Regulation of rat liver microsomal cholesterol_7_alpha-hydroxylase by MgATP : effect of pH. Cholesterol_7_alpha-hydroxylase when assayed under conditions that favour phosphorylation can be activated or inactivated by MgATP , depending on ATP concentration and the pH of the incubation medium .
25225655	0	MgCl2	21,26	CO2	110,113	MgCl2	CO2	MESH:D015636	717	Chemical	Gene	roles|nmod|START_ENTITY roles|nmod|END_ENTITY	The crucial roles of MgCl2 as a non-innocent additive in the Ni-catalyzed carboxylation of benzyl_halide with CO2 .
19303209	0	Mg_chloride	58,69	CO2	49,52	Mg chloride	CO2	null	717	Chemical	Gene	solution|compound|START_ENTITY END_ENTITY|nmod|solution	Synthesis of nesquehonite by reaction of gaseous CO2 with Mg_chloride solution : its potential role in the sequestration of carbon_dioxide .
23962556	0	MiR-101	0,7	MITF	71,75	MiR-101	MITF	null	4286	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MiR-101 inhibits melanoma cell invasion and proliferation by targeting MITF and EZH2 .
23250910	0	MiR-124	0,7	Slug	16,20	MiR-124	Slug	null	6591	Chemical	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	MiR-124 targets Slug to regulate epithelial-mesenchymal transition and metastasis of breast_cancer .
24279510	0	MiR-124	0,7	SphK1	81,86	MiR-124	SphK1	null	8877	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	MiR-124 inhibits the migration and invasion of ovarian_cancer cells by targeting SphK1 .
25218344	0	MiR-124	0,7	amotL1	70,76	MiR-124	amotL1	null	154810	Chemical	Gene	represses|nsubj|START_ENTITY represses|advcl|targeting targeting|dobj|END_ENTITY	MiR-124 represses vasculogenic mimicry and cell motility by targeting amotL1 in cervical_cancer cells .
25716201	0	MiR-129	0,7	MMP9	18,22	MiR-129	MMP9	null	4318	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	MiR-129 regulates MMP9 to control metastasis of non-small_cell_lung_cancer .
26283050	0	MiR-138	0,7	GIT1	132,136	MiR-138	GIT1	null	28964	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MiR-138 inhibits cell proliferation and reverses epithelial-mesenchymal transition in non-small_cell_lung_cancer cells by targeting GIT1 and SEMA4C .
21875287	0	MiR-138	0,7	HIF-1a	62,68	MiR-138	HIF-1a	null	3091	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|nmod|END_ENTITY	MiR-138 suppresses expression of hypoxia-inducible_factor_1a -LRB- HIF-1a -RRB- in clear_cell_renal_cell_carcinoma 786-O cells .
24057215	0	MiR-138	0,7	RMND5A	66,72	MiR-138	RMND5A	null	64795	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|nmod|END_ENTITY	MiR-138 downregulates miRNA processing in HeLa cells by targeting RMND5A and decreasing Exportin-5 stability .
23811549	0	MiR-143	0,7	AIM2	30,34	MiR-143	AIM2	null	9447	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	MiR-143 induces expression of AIM2 and ASC in Jurkat cell line .
22396742	0	MiR-194	0,7	Sox5	96,100	MiR-194	Sox5	null	6660	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	MiR-194 regulates chondrogenic differentiation of human adipose-derived stem cells by targeting Sox5 .
24022342	0	MiR-199a	0,8	HIF1a	108,113	MiR-199a	HIF1a	null	3091	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	MiR-199a suppresses the hypoxia-induced proliferation of non-small cell lung_cancer cells through targeting HIF1a .
22766851	0	MiR-218	0,7	LEF1	105,109	MiR-218	LEF1	null	51176	Chemical	Gene	reverses|nsubj|START_ENTITY reverses|advcl|targeting targeting|dobj|END_ENTITY	MiR-218 reverses high invasiveness of glioblastoma cells by targeting the oncogenic transcription factor LEF1 .
22185756	0	MiR-365	0,7	thyroid_transcription_factor_1	53,83	MiR-365	thyroid transcription factor 1	null	7080	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	MiR-365 regulates lung_cancer and developmental gene thyroid_transcription_factor_1 .
26333174	0	MiR-622	0,7	K-Ras	77,82	MiR-622	K-Ras	null	24525(Tax:10116)	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|nmod|END_ENTITY	MiR-622 inhibited colorectal_cancer occurrence and metastasis by suppressing K-Ras .
18686603	0	MiR-9	1,6	CBX7	35,39	MiR-9	CBX7	null	23492	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	-LSB- MiR-9 regulates the expression of CBX7 in human glioma -RSB- .
24413174	0	MiR-9	0,5	Cthrc1	51,57	MiR-9	Cthrc1	null	282836(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MiR-9 inhibits Schwann cell migration by targeting Cthrc1 following sciatic nerve_injury .
24283529	0	Mianserin	0,9	5-HT2_receptor	13,27	Mianserin	5-HT2 receptor	MESH:D008803	3356	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Mianserin , a 5-HT2_receptor antagonist , in the treatment of delirium : an open study .
10226769	0	Mibefradil	0,10	CYP3A	21,26	Mibefradil	CYP3A	MESH:D020748	1576	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Mibefradil , a potent CYP3A inhibitor , does not alter pravastatin pharmacokinetics .
10546924	0	Mibefradil	0,10	CYP3A4	86,92	Mibefradil	CYP3A4	MESH:D020748	1576	Chemical	Gene	elevates|nsubj|START_ENTITY elevates|dobj|concentrations concentrations|nmod|triazolam triazolam|compound|END_ENTITY	Mibefradil but not isradipine substantially elevates the plasma concentrations of the CYP3A4 substrate triazolam .
20417621	0	MicroRNA-1285	0,13	p53	41,44	MicroRNA-1285	p53	null	7157	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	MicroRNA-1285 inhibits the expression of p53 by directly targeting its 3 ' untranslated region .
24375253	0	MicroRNA-218	0,12	KIT	84,87	MicroRNA-218	KIT	null	3815	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-218 inhibits gastrointestinal_stromal_tumor cell and invasion by targeting KIT .
16574659	0	Microcin_C	72,82	Aspartyl-tRNA_synthetase	0,24	Microcin C	Aspartyl-tRNA synthetase	null	1615	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Aspartyl-tRNA_synthetase is the target of peptide nucleotide antibiotic Microcin_C .
15845749	0	Midazolam	0,9	CYP3A4	98,104	Midazolam	CYP3A4	MESH:D008874	1576	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|nmod|END_ENTITY	Midazolam and cyclosporin_a metabolism in transgenic_mice with liver-specific expression of human CYP3A4 .
16372144	0	Midazolam	0,9	Fos	37,40	Midazolam	Fos	MESH:D008874	314322(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Midazolam inhibits neophobia-induced Fos expression in the rat hippocampus .
15717703	0	Midazolam	0,9	P-selectin	51,61	Midazolam	P-selectin	MESH:D008874	6403	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|amod|END_ENTITY	Midazolam attenuates adenosine_diphosphate-induced P-selectin expression and platelet-leucocyte aggregation .
12145054	0	Midazolam	0,9	c-Fos	32,37	Midazolam	c-Fos	MESH:D008874	314322(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Midazolam induces expression of c-Fos and EGR-1 by a non-GABAergic mechanism .
7788644	0	Midazolam	0,9	c-fos	146,151	Midazolam	c-fos	MESH:D008874	2353	Chemical	Gene	attenuate|nsubj|START_ENTITY attenuate|dobj|expression expression|nmod|mRNA mRNA|amod|END_ENTITY	Midazolam and the N-methyl-D-aspartate -LRB- NMDA -RRB- receptor antagonist 2-amino-7-phosphonoheptanoic_acid -LRB- AP-7 -RRB- attenuate stress-induced expression of c-fos mRNA in the dentate gyrus .
21682888	0	Midazolam	0,9	interleukin-6	44,57	Midazolam	interleukin-6	MESH:D008874	24498(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|release release|amod|END_ENTITY	Midazolam suppresses interleukin-1b-induced interleukin-6 release from rat glial cells .
24988461	0	Midazolam	0,9	translocator_protein	109,129	Midazolam	translocator protein	MESH:D008874	12257(Tax:10090)	Chemical	Gene	ameliorates|nsubj|START_ENTITY ameliorates|nmod|END_ENTITY	Midazolam ameliorates the behavior deficits of a rat posttraumatic stress_disorder model through dual 18 kDa translocator_protein and central benzodiazepine receptor and neurosteroidogenesis .
12717136	0	Midazolam	0,9	vascular_endothelial_growth_factor	21,55	Midazolam	vascular endothelial growth factor	MESH:D008874	83785(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY release|compound|END_ENTITY	Midazolam stimulates vascular_endothelial_growth_factor release in aortic smooth muscle cells : role of the mitogen-activated_protein kinase superfamily .
18390992	0	Mifepristone	0,12	ACTH	25,29	Mifepristone	ACTH	MESH:D015735	5443	Chemical	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	Mifepristone for ectopic ACTH secretion in metastatic endocrine carcinomas : report of two cases .
25013998	0	Mifepristone	164,176	ACTH	18,22	Mifepristone	ACTH	MESH:D015735	5443	Chemical	Gene	START_ENTITY|nsubj|Changes Changes|nmod|Levels Levels|compound|END_ENTITY	Changes in Plasma ACTH Levels and Corticotroph Tumor Size in Patients With Cushing 's _ Disease During Long-term Treatment With the Glucocorticoid Receptor Antagonist Mifepristone .
18819906	0	Mifepristone	1,13	glucosylceramide_synthase	24,49	Mifepristone	glucosylceramide synthase	MESH:D015735	7357	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	-LSB- Mifepristone modulates glucosylceramide_synthase expression and reverse multidrug resistance in ovarian_cancer cells -RSB- .
2744189	0	Mifepristone	70,82	placental_protein_14	22,42	Mifepristone	placental protein 14	MESH:D015735	5047	Chemical	Gene	levels|nmod|START_ENTITY levels|nmod|END_ENTITY	Circulating levels of placental_protein_14 and progesterone following Mifepristone -LRB- RU38486 -RRB- and Gemeprost for termination of first trimester pregnancy .
17950094	0	Miglitol	0,8	adiponectin	23,34	Miglitol	adiponectin	MESH:C045621	9370	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|level level|compound|END_ENTITY	Miglitol increases the adiponectin level and decreases urinary albumin excretion in patients with type_2_diabetes_mellitus .
21898126	0	Miglitol	0,8	glucagon-like_peptide-1	63,86	Miglitol	glucagon-like peptide-1	MESH:C045621	2641	Chemical	Gene	increased|nsubj|START_ENTITY increased|iobj|plasma plasma|amod|END_ENTITY	Miglitol administered before breakfast increased plasma active glucagon-like_peptide-1 -LRB- GLP-1 -RRB- levels after lunch in patients with type 2 diabetes treated with sitagliptin .
18702958	0	Miglitol	0,8	interleukin_6	49,62	Miglitol	interleukin 6	MESH:C045621	3569	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	Miglitol suppresses the postprandial increase in interleukin_6 and enhances active glucagon-like_peptide_1 secretion in viscerally_obese subjects .
24669882	0	Miglitol	0,8	uncoupling_protein_1	54,74	Miglitol	uncoupling protein 1	MESH:C045621	22227(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|nmod|END_ENTITY	Miglitol increases energy expenditure by upregulating uncoupling_protein_1 of brown adipose tissue and reduces obesity in dietary-induced obese mice .
20504633	0	Milacemide	0,10	monoamine_oxidase_B	79,98	Milacemide	monoamine oxidase B	MESH:C039332	708468(Tax:9544)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Milacemide , the selective substrate and enzyme-activated specific inhibitor of monoamine_oxidase_B , increases dopamine but not serotonin in caudate nucleus of rhesus_monkey .
25358426	0	Milnacipran	80,91	Bcl1	0,4	Milnacipran	Bcl1	MESH:C048107	595	Chemical	Gene	Polymorphism|nmod|START_ENTITY Polymorphism|compound|END_ENTITY	Bcl1 Polymorphism of the Glucocorticoid_Receptor Gene and Treatment Response to Milnacipran and Fluvoxamine in Japanese Patients with Depression .
7637154	0	Milrinone	1,10	TNF-alpha	22,31	Milrinone	TNF-alpha	MESH:D020105	21926(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|release release|amod|END_ENTITY	-LSB- Milrinone suppresses TNF-alpha and IL-1_beta release in mouse peritoneal macrophages -RSB- .
14624413	0	Milrinone	0,9	phosphodiesterase_3	23,42	Milrinone	phosphodiesterase 3	MESH:D020105	498900(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Milrinone , a selective phosphodiesterase_3 inhibitor , stimulates lipolysis , endogenous glucose production , and insulin secretion .
26903515	0	Miltefosine	36,47	ABCA3	25,30	Miltefosine	ABCA3	MESH:C039128	21	Chemical	Gene	Transporter|compound|START_ENTITY END_ENTITY|nmod|Transporter	Functional Validation of ABCA3 as a Miltefosine Transporter in Human Macrophages : Impact on Intracellular Survival of Leishmania _ -LRB- Viannia -RRB- panamensis .
26339922	0	Miltirone	0,9	P-Glycoprotein	33,47	Miltirone	P-Glycoprotein	MESH:C068880	5243	Chemical	Gene	Inhibitor|nsubj|START_ENTITY Inhibitor|nmod|END_ENTITY	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells .
16574083	0	Minocycline	0,11	5-lipoxygenase	75,89	Minocycline	5-lipoxygenase	MESH:D008911	25290(Tax:10116)	Chemical	Gene	protects|nsubj|START_ENTITY protects|dobj|cells cells|nmod|injury injury|acl|inhibiting inhibiting|dobj|activation activation|amod|END_ENTITY	Minocycline protects PC12 cells against NMDA-induced injury via inhibiting 5-lipoxygenase activation .
17506934	0	Minocycline	0,11	5-lipoxygenase	21,35	Minocycline	5-lipoxygenase	MESH:D008911	25290(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	Minocycline inhibits 5-lipoxygenase activation and brain_inflammation after focal cerebral_ischemia in rats .
20006627	0	Minocycline	0,11	5-lipoxygenase	21,35	Minocycline	5-lipoxygenase	MESH:D008911	25290(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Minocycline inhibits 5-lipoxygenase expression and accelerates functional recovery in chronic phase of focal cerebral_ischemia in rats .
16202388	0	Minocycline	0,11	BCL-2	25,30	Minocycline	BCL-2	MESH:D008911	596	Chemical	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	Minocycline up-regulates BCL-2 levels in mitochondria and attenuates male germ cell apoptosis .
15004018	0	Minocycline	0,11	Bcl-2	25,30	Minocycline	Bcl-2	MESH:D008911	596	Chemical	Gene	up-regulates|amod|START_ENTITY END_ENTITY|nsubj|up-regulates	Minocycline up-regulates Bcl-2 and protects against cell death in mitochondria .
24410139	0	Minocycline	0,11	Bcl-2	54,59	Minocycline	Bcl-2	MESH:D008911	24224(Tax:10116)	Chemical	Gene	mechanism|amod|START_ENTITY involves|nsubj|mechanism involves|dobj|family family|compound|END_ENTITY	Minocycline mechanism of neuroprotection involves the Bcl-2 gene family in optic_nerve_transection .
26212550	0	Minocycline	0,11	Rad51	94,99	Minocycline	Rad51	MESH:D008911	5888	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|expression expression|compound|END_ENTITY	Minocycline enhances mitomycin_C-induced cytotoxicity through down-regulating ERK1/2-mediated Rad51 expression in human non-small_cell_lung_cancer cells .
24513126	0	Minocycline	0,11	TNF-a	46,51	Minocycline	TNF-a	MESH:D008911	24835(Tax:10116)	Chemical	Gene	levels|amod|START_ENTITY levels|nmod|END_ENTITY	Minocycline attenuates brain tissue levels of TNF-a produced by neurons after prolonged hypothermic cardiac_arrest in rats .
10888929	0	Minocycline	0,11	caspase-1	21,30	Minocycline	caspase-1	MESH:D008911	12362(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington_disease .
11383749	0	Minocycline	0,11	caspase-1	52,61	Minocycline	caspase-1	MESH:D008911	12362(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|activation activation|amod|END_ENTITY	Minocycline reduces traumatic_brain_injury-mediated caspase-1 activation , tissue damage , and neurological_dysfunction .
15990464	0	Minocycline	0,11	caspase-3	31,40	Minocycline	caspase-3	MESH:D008911	25402(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	Minocycline partially inhibits caspase-3 activation and photoreceptor_degeneration after photic_injury .
21524889	0	Minoxidil	0,9	b-catenin	20,29	Minoxidil	b-catenin	MESH:D008914	1499	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|pathway pathway|amod|END_ENTITY	Minoxidil activates b-catenin pathway in human dermal_papilla cells : a possible explanation for its anagen prolongation effect .
7979390	0	Minoxidil	0,9	elastin	21,28	Minoxidil	elastin	MESH:D008914	2006	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	Minoxidil stimulates elastin expression in aortic smooth muscle cells .
1314568	0	Minoxidil	0,9	lysine_hydroxylase	51,69	Minoxidil	lysine hydroxylase	MESH:D008914	5351	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|nmod|END_ENTITY	Minoxidil specifically decreases the expression of lysine_hydroxylase in cultured human skin fibroblasts .
25521658	0	Mirabegron	0,10	Beta-3	14,20	Mirabegron	Beta-3	MESH:C520025	1934	Chemical	Gene	START_ENTITY|dep|agonist agonist|compound|END_ENTITY	Mirabegron : a Beta-3 agonist for overactive_bladder .
25791612	0	Mirabegron	20,30	b3-Adrenoceptor	34,49	Mirabegron	b3-Adrenoceptor	MESH:C520025	155	Chemical	Gene	Pharmacokinetics|nmod|START_ENTITY Pharmacokinetics|appos|Agonist Agonist|amod|END_ENTITY	Pharmacokinetics of Mirabegron , a b3-Adrenoceptor Agonist for Treatment of Overactive Bladder , in Healthy East Asian Subjects .
26493129	0	Mirabegron	0,10	b3-adrenoceptor	72,87	Mirabegron	b3-adrenoceptor	MESH:C520025	155	Chemical	Gene	relaxes|nsubj|START_ENTITY relaxes|nmod|mechanism mechanism|nmod|activation activation|amod|END_ENTITY	Mirabegron relaxes urethral smooth muscle by a dual mechanism involving b3-adrenoceptor activation and a1-adrenoceptor blockade .
24431668	0	Misoprostol	8,19	Oxytocin	105,113	Misoprostol	Oxytocin	MESH:D016595	5020	Chemical	Gene	Role|nmod|START_ENTITY mcg|nsubj|Role mcg|dobj|Oral Oral|dep|Study Study|nmod|OBJECTIVES OBJECTIVES|compound|END_ENTITY	Role of Misoprostol 600 mcg Oral in Active Management of Third Stage of Labor : A Comparative Study with Oxytocin 10 IU i.m. OBJECTIVES : To compare oral misopostol 600 mcg with 10 IU units oxytocin i.m. in the active management of the third stage of labor .
19069889	0	Misoprostol	8,19	oxytocin	40,48	Misoprostol	oxytocin	MESH:D016595	5020	Chemical	Gene	START_ENTITY|nmod|dose dose|nmod|END_ENTITY	Vaginal Misoprostol versus high dose of oxytocin for labor induction : a comparative study .
21543616	0	Mithramycin	0,11	Sp1	32,35	Mithramycin	Sp1	MESH:D008926	24790(Tax:10116)	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|amod|END_ENTITY	Mithramycin is a gene-selective Sp1 inhibitor that identifies a biological intersection between cancer and neurodegeneration .
26459178	0	Mithramycin	0,11	p53	57,60	Mithramycin	p53	MESH:D008926	7157	Chemical	Gene	Depletes|nsubj|START_ENTITY Depletes|dobj|END_ENTITY	Mithramycin Depletes Specificity_Protein_1 and Activates p53 to Mediate Senescence and Apoptosis of Malignant_Pleural_Mesothelioma Cells .
21046154	0	Mithramycin_A	0,13	ABCB8	74,79	Mithramycin A	ABCB8	MESH:C066851	11194	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|nmod|END_ENTITY	Mithramycin_A suppresses expression of the human melanoma-associated gene ABCB8 .
23019217	0	Mithramycin_A	0,13	myeloid_cell_leukemia-1	23,46	Mithramycin A	myeloid cell leukemia-1	MESH:C066851	4170	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Mithramycin_A inhibits myeloid_cell_leukemia-1 to induce apoptosis in oral_squamous_cell_carcinomas and tumor xenograft through activation of Bax and oligomerization .
11085512	0	Mitomycin_C	0,11	DT-diaphorase	108,121	Mitomycin C	DT-diaphorase	MESH:D016685	1728	Chemical	Gene	resistance|amod|START_ENTITY associated|nsubjpass|resistance associated|nmod|down-regulation down-regulation|amod|END_ENTITY	Mitomycin_C resistance induced by TCF-3 overexpression in gastric_cancer cell line MKN28 is associated with DT-diaphorase down-regulation .
8264549	5	Mitomycin_C	485,496	DT-diaphorase	521,534	Mitomycin C	DT-diaphorase	MESH:D016685	1728	Chemical	Gene	bound|nsubjpass|START_ENTITY bound|nmod|END_ENTITY	-LSB- 3H -RSB- Mitomycin_C was covalently bound to DT-diaphorase during inhibition , and the stoichiometry for inactivation of DT-diaphorase by mitomycin_C was approximately 0.8 nmol of mitomycin_C bound/nmol of enzyme .
17460254	0	Mitomycin_C	0,11	IL-8	24,28	Mitomycin C	IL-8	MESH:D016685	3576	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Mitomycin_C upregulates IL-8 and MCP-1 chemokine expression via mitogen-activated protein kinases in corneal fibroblasts .
24049721	0	Mitomycin_C	46,57	P-glycoprotein	0,14	Mitomycin C	P-glycoprotein	MESH:D016685	5243	Chemical	Gene	Effect|nmod|START_ENTITY Augment|dep|Effect Augment|compound|END_ENTITY	P-glycoprotein Blockers Augment the Effect of Mitomycin_C on Human Tenon 's Fibroblasts .
25681288	0	Mitomycin_C	61,72	Survivin	31,39	Mitomycin C	Survivin	MESH:D016685	11799(Tax:10090)	Chemical	Gene	Activity|nmod|START_ENTITY Activity|compound|END_ENTITY	Intravenous siRNA Silencing of Survivin Enhances Activity of Mitomycin_C in Human Bladder RT4 Xenografts .
26915147	0	Mitomycin_C	10,21	bFGF	25,29	Mitomycin C	bFGF	MESH:D016685	54250(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of Mitomycin_C on bFGF , TGF-b1 , KGF-1 Expressions after Myringotomy : An Animal Study .
26254780	0	Mitomycin_C	0,11	miR-200b	86,94	Mitomycin C	miR-200b	MESH:D016685	406984	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|regulating regulating|dobj|END_ENTITY	Mitomycin_C induces fibroblasts apoptosis and reduces_epidural_fibrosis by regulating miR-200b and its targeting of RhoE .
23179081	0	Mitotane	0,8	CYP3A4	17,23	Mitotane	CYP3A4	MESH:D008939	1576	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nummod|END_ENTITY	Mitotane induces CYP3A4 expression via activation of the steroid_and_xenobiotic_receptor .
25096913	0	Mitotane	0,8	P-gp	63,67	Mitotane	P-gp	MESH:D008939	5243	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|advcl|inhibiting inhibiting|dobj|END_ENTITY	Mitotane enhances doxorubicin cytotoxic activity by inhibiting P-gp in human adrenocortical_carcinoma cells .
20691148	0	Mitoxantrone	0,12	ABCG2	32,37	Mitoxantrone	ABCG2	MESH:D008942	9429	Chemical	Gene	expelled|nsubjpass|START_ENTITY expelled|nmod|END_ENTITY	Mitoxantrone is expelled by the ABCG2 multidrug transporter directly from the plasma membrane .
21653687	0	Mitoxantrone	0,12	HIF-1a	22,28	Mitoxantrone	HIF-1a	MESH:D008942	3091	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Mitoxantrone inhibits HIF-1a expression in a topoisomerase II-independent pathway .
15833373	0	Mitoxantrone	0,12	IFN-beta	86,94	Mitoxantrone	IFN-beta	MESH:D008942	3456	Chemical	Gene	START_ENTITY|nmod|patients patients|acl|receiving receiving|dobj|END_ENTITY	Mitoxantrone as rescue therapy in worsening relapsing-remitting MS patients receiving IFN-beta .
25974135	0	Mitoxantrone	36,48	Tyrosine_Kinase	60,75	Mitoxantrone	Tyrosine Kinase	MESH:D008942	7294	Chemical	Gene	START_ENTITY|nmod|Activation Activation|compound|END_ENTITY	Stromal CYR61 Confers Resistance to Mitoxantrone via Spleen Tyrosine_Kinase Activation in Human Acute Myeloid Leukaemia .
11596021	0	Mitoxantrone	0,12	prostate_specific_antigen	30,55	Mitoxantrone	prostate specific antigen	MESH:D008942	354	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|progression progression|compound|END_ENTITY	Mitoxantrone in patients with prostate_specific_antigen progression after local therapy for prostate_carcinoma .
23696131	0	Mitoxantrone	0,12	ubiquitin-specific_peptidase_11	27,58	Mitoxantrone	ubiquitin-specific peptidase 11	MESH:D008942	8237	Chemical	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Mitoxantrone targets human ubiquitin-specific_peptidase_11 -LRB- USP11 -RRB- and is a potent inhibitor of pancreatic_cancer cell survival .
21513785	0	Mitragynine	0,11	COX-2	25,30	Mitragynine	COX-2	MESH:C001801	17709(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Mitragynine inhibits the COX-2 mRNA expression and prostaglandin_E production induced by lipopolysaccharide in RAW264 .7 macrophage cells .
22085688	0	Mizoribine	0,10	cyclosporine_A	88,102	Mizoribine	cyclosporine A	MESH:C010052	71991(Tax:10090)	Chemical	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	Mizoribine -- an inosine_monophosphate dehydrogenase inhibitor -- acts synergistically with cyclosporine_A in prolonging survival of murine islet cell and heart transplants across major histocompatibility barrier .
24387017	0	Mizoribine	0,10	interleukin-6	74,87	Mizoribine	interleukin-6	MESH:C010052	3569	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Mizoribine , an inhibitor of inosine_monophosphate dehydrogenase , inhibits interleukin-6 production by freshly prepared rheumatoid_synovial cells .
24134561	0	Mizoribine	0,10	monocyte_chemoattractant_protein-1	34,68	Mizoribine	monocyte chemoattractant protein-1	MESH:C010052	6347	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|production production|amod|END_ENTITY	Mizoribine selectively attenuates monocyte_chemoattractant_protein-1 production in cultured human glomerular mesangial cell : a possible benefit of its use in the treatment of lupus_nephritis .
17227451	0	MnTBAP	0,6	tumor_necrosis_factor-alpha	61,88	MnTBAP	tumor necrosis factor-alpha	MESH:C097284	21926(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|nmod|END_ENTITY	MnTBAP , a synthetic metalloporphyrin , inhibits production of tumor_necrosis_factor-alpha in lipopolysaccharide-stimulated RAW 264.7 macrophages cells via inhibiting oxidative stress-mediating p38 and SAPK/JNK signaling .
19949914	0	Mn_superoxide	99,112	Cu-Zn_superoxide_dismutase	71,97	Mn superoxide	Cu-Zn superoxide dismutase	null	6647	Chemical	Gene	dismutase|amod|START_ENTITY dismutase|amod|END_ENTITY	Cigarette smoke condensate causes a decrease of the gene expression of Cu-Zn_superoxide_dismutase , Mn_superoxide dismutase , glutathione peroxidase , catalase , and free radical-induced cell injury in SH-SY5Y human neuroblastoma cells .
3099572	9	Mo	1164,1166	IFN-alpha	1129,1138	Mo	IFN-alpha	null	3439	Chemical	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|effect effect|nmod|END_ENTITY	The inhibitory effect of IFN-alpha was not mediated through Mo and could be achieved by preincubating the T-cells with IFN-alpha .
18964090	0	Mo	14,16	SCN	81,84	Mo	SCN	null	6717	Chemical	Gene	Extraction|nmod|START_ENTITY Extraction|nmod|END_ENTITY	Extraction of Mo , W and Tc with polyurethane foam and with cyclic polyether from SCN - / HCL medium .
19682495	0	Mo-DC	61,66	NOG	100,103	Mo-DC	NOG	null	9241	Chemical	Gene	mice|amod|START_ENTITY mice|appos|END_ENTITY	An in vivo model of priming of antigen-specific human CTL by Mo-DC in NOD/Shi-scid IL2rgamma -LRB- null -RRB- -LRB- NOG -RRB- mice .
15918155	3	MoAb	553,557	mice	526,530	MoAb	FACS	null	14081(Tax:10090)	Chemical	Gene	injection|nmod|START_ENTITY END_ENTITY|nmod|injection	To elucidate the role of this IgM autoantibody in hepatocyte injury , we examined the reactivity of this MoAb to murine hepatocytes and then questioned whether acute_hepatic_injury could be induced in mice via injection of this MoAb .
8182055	0	MoCo	41,45	nitrate_reductase	56,73	MoCo	nitrate reductase	CHEBI:21437	844112(Tax:3702)	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	A glycine to aspartic_acid change in the MoCo domain of nitrate_reductase reduces both activity and phosphorylation levels in Arabidopsis .
7781267	0	Moclobemide	0,11	CYP2C19	28,35	Moclobemide	CYP2C19	MESH:D020912	1557	Chemical	Gene	START_ENTITY|appos|substrate substrate|nmod|END_ENTITY	Moclobemide , a substrate of CYP2C19 and an inhibitor of CYP2C19 , CYP2D6 , and CYP1A2 : a panel study .
2300680	0	Moclobemide	0,11	MAO-A	29,34	Moclobemide	MAO-A	MESH:D020912	4128	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Moclobemide , an inhibitor of MAO-A , does not increase daytime plasma melatonin levels in normal humans .
26316187	0	Moclobemide	33,44	Monoamine_Oxidase-A	0,19	Moclobemide	Monoamine Oxidase-A	MESH:D020912	4128	Chemical	Gene	Occupancy|nmod|START_ENTITY Occupancy|compound|END_ENTITY	Monoamine_Oxidase-A Occupancy by Moclobemide and Phenelzine : Implications for the Development of Monoamine Oxidase Inhibitors .
8490690	0	Moclobemide	0,11	monoamine_oxidase_type_A	39,63	Moclobemide	monoamine oxidase type A	MESH:D020912	4128	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	Moclobemide : a reversible inhibitor of monoamine_oxidase_type_A .
22749868	0	Modafinil	0,9	P300	44,48	Modafinil	P300	MESH:C048833	2033	Chemical	Gene	improves|nsubj|START_ENTITY improves|ccomp|potentials potentials|dobj|variation variation|amod|END_ENTITY	Modafinil improves event related potentials P300 and contingent negative variation after 24 h sleep_deprivation .
20809259	0	Moderate	0,8	GSK-3b	9,15	Moderate	GSK-3b	null	2932	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|compound|END_ENTITY	Moderate GSK-3b inhibition improves neovascular architecture , reduces vascular leakage , and reduces retinal hypoxia in a model of ischemic_retinopathy .
16793908	0	Moderate	0,8	endostatin	68,78	Moderate	endostatin	null	12822(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Moderate antiangiogenic activity by local , transgenic expression of endostatin in Rip1Tag2 transgenic_mice .
7473177	0	Moexipril	0,9	ACE	48,51	Moexipril	ACE	MESH:C058302	24310(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|appos|END_ENTITY	Moexipril , a new angiotensin-converting enzyme -LRB- ACE -RRB- inhibitor : pharmacological characterization and comparison with enalapril .
19716835	0	Mollugin	0,8	JNK	111,114	Mollugin	JNK	MESH:C046245	5599	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Mollugin induces apoptosis in human Jurkat T cells through endoplasmic reticulum stress-mediated activation of JNK and caspase-12 and subsequent activation of mitochondria-dependent caspase cascade regulated by Bcl-xL .
21237248	0	Molsidomine	0,11	cNOS	26,30	Molsidomine	cNOS	MESH:D008981	24600(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activity activity|amod|END_ENTITY	Molsidomine modulates the cNOS activity in an experimental model of cholinergic damage induced by 192-IgG saporin .
10090774	0	Molybdate	0,9	hsp90	19,24	Molybdate	hsp90	MESH:C044659	3320	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Molybdate inhibits hsp90 , induces structural changes in its C-terminal domain , and alters its interactions with substrates .
4954639	0	Molybdenum	0,10	xanthine_dehydrogenase	37,59	Molybdenum	xanthine dehydrogenase	MESH:D008982	7498	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Molybdenum requirement for bacterial xanthine_dehydrogenase activity .
10754199	0	Momordin_I	0,10	AP-1	53,57	Momordin I	AP-1	null	16476(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|compound|END_ENTITY	Momordin_I , a compound of ampelopsis radix , inhibits AP-1 activation induced by phorbol_ester .
16213465	0	Momordin_I	0,10	AP-1	28,32	Momordin I	AP-1	null	16476(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Momordin_I , an inhibitor of AP-1 , suppressed osteoclastogenesis through inhibition of NF-kappaB and AP-1 and also reduced osteoclast activity and survival .
8557561	0	Monamidocin	0,11	fibrinogen	21,31	Monamidocin	fibrinogen	null	2244	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Monamidocin , a novel fibrinogen receptor antagonist .
15665380	0	Monastrol	0,9	Eg5	44,47	Monastrol	Eg5	MESH:C400223	3832	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Monastrol inhibition of the mitotic kinesin Eg5 .
23615398	0	Monensin	0,8	TRAIL	54,59	Monensin	TRAIL	MESH:D008985	8743	Chemical	Gene	overcomes|nsubj|START_ENTITY overcomes|dobj|resistance resistance|amod|END_ENTITY	Monensin , a polyether ionophore antibiotic , overcomes TRAIL resistance in glioma cells via endoplasmic reticulum stress , DR5 upregulation and c-FLIP downregulation .
3734935	0	Monensin	0,8	arylsulfatase_B	24,39	Monensin	arylsulfatase B	MESH:D008985	411	Chemical	Gene	stimulation|compound|START_ENTITY stimulation|nmod|activity activity|amod|END_ENTITY	Monensin stimulation of arylsulfatase_B activity in human chondrocytes .
379715	0	Monoamine	0,9	LRF	31,34	Monoamine	LRF	CHEBI:25375	153222	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Monoamine neuron regulation of LRF neurons innervating the organum vasculosum laminae terminalis and median eminence .
25272089	0	Monoammonium_glycyrrhizate	0,26	tumor_necrosis_factor-a	38,61	Monoammonium glycyrrhizate	tumor necrosis factor-a	null	7124	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|production production|amod|END_ENTITY	Monoammonium_glycyrrhizate suppresses tumor_necrosis_factor-a induced chemokine production in HMEC-1 cells , possibly by blocking the translocation of nuclear factor-kB into the nucleus .
23690213	0	Monobutyl_phthalate	0,19	G-Protein-Coupled_Receptor_30	53,82	Monobutyl phthalate	G-Protein-Coupled Receptor 30	MESH:C028577	171104(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|change change|nmod|END_ENTITY	Monobutyl_phthalate induces the expression change of G-Protein-Coupled_Receptor_30 in rat testicular Sertoli cells .
25225794	0	Monocarboxylate	0,15	MCT1	43,47	Monocarboxylate	MCT1	CHEBI:35757	6566	Chemical	Gene	transporters|nsubj|START_ENTITY transporters|parataxis|marker marker|nsubj|END_ENTITY	Monocarboxylate transporters 1-4 in NSCLC : MCT1 is an independent prognostic marker for survival .
10794666	0	Monocarboxylic_acid	0,19	MCT1	34,38	Monocarboxylic acid	MCT1	CHEBI:25384	6566	Chemical	Gene	transporters|amod|START_ENTITY transporters|appos|END_ENTITY	Monocarboxylic_acid transporters , MCT1 and MCT2 , in cortical astrocytes in vitro and in vivo .
24799634	0	Monocarboxylic_acid	25,44	MCT2	60,64	Monocarboxylic acid	MCT2	CHEBI:25384	9194	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	The genetic variation in Monocarboxylic_acid transporter 2 -LRB- MCT2 -RRB- has functional and clinical relevance with male_infertility .
10647997	0	Monochloramine	0,14	CD95	35,39	Monochloramine	CD95	MESH:C030816	355	Chemical	Gene	Fas|compound|START_ENTITY Fas|appos|END_ENTITY	Monochloramine enhances Fas -LRB- APO-1 / CD95 -RRB- - induced apoptosis in Jurkat T cells .
12420742	0	Monochloramine	0,14	E-selectin	42,52	Monochloramine	E-selectin	MESH:C030816	6401	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Monochloramine inhibits the expression of E-selectin and intercellular_adhesion_molecule-1 induced by TNF-alpha through the suppression of NF-kappaB activation in human endothelial cells .
16414131	0	Monochloramine	0,14	p53	46,49	Monochloramine	p53	MESH:C030816	7157	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|compound|END_ENTITY	Monochloramine inhibits ultraviolet B-induced p53 activation and DNA repair response in human fibroblasts .
11720614	0	Monocrotaline	0,13	interleukin-6	22,35	Monocrotaline	interleukin-6	MESH:D016686	24498(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Monocrotaline induces interleukin-6 mRNA expression in rat lungs .
26236921	0	Monoethanolamine	31,47	CO2	14,17	Monoethanolamine	CO2	MESH:D019856	717	Chemical	Gene	Capture|nmod|START_ENTITY Capture|compound|END_ENTITY	Mechanisms of CO2 Capture into Monoethanolamine Solution with Different CO2 Loading during the Absorption/Desorption Processes .
1310133	0	Monokines	0,9	erythropoietin	21,35	Monokines	erythropoietin	MESH:D015846	2056	Chemical	Gene	START_ENTITY|acl|inhibiting inhibiting|dobj|production production|compound|END_ENTITY	Monokines inhibiting erythropoietin production in human hepatoma cultures and in isolated perfused rat kidneys .
26518055	0	Monomethylarsonous_acid	0,23	IL-7	41,45	Monomethylarsonous acid	IL-7	MESH:C406082	16196(Tax:10090)	Chemical	Gene	Inhibits|nsubj|START_ENTITY Inhibits|dobj|Signaling Signaling|compound|END_ENTITY	Monomethylarsonous_acid -LRB- MMA +3 -RRB- Inhibits IL-7 Signaling in Mouse Pre-B Cells .
7955423	0	Monosaccharide	0,14	haptoglobin	30,41	Monosaccharide	haptoglobin	CHEBI:35381	3240	Chemical	Gene	composition|amod|START_ENTITY composition|nmod|END_ENTITY	Monosaccharide composition of haptoglobin in liver_diseases and alcohol_abuse : large changes in glycosylation associated with alcoholic_liver_disease .
12475613	0	Monosaccharide	0,14	peroxidase	69,79	Monosaccharide	peroxidase	CHEBI:35381	106444911	Chemical	Gene	composition|amod|START_ENTITY composition|nmod|END_ENTITY	Monosaccharide composition and properties of a deglycosylated turnip peroxidase isozyme .
15293557	0	Monosialoganglioside	0,20	catalase	31,39	Monosialoganglioside	catalase	null	24248(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|activity activity|amod|END_ENTITY	Monosialoganglioside increases catalase activity in cerebral cortex of rats .
26454448	0	Monosodium_Urate	22,38	Interleukin-1b	55,69	Monosodium Urate	Interleukin-1b	MESH:D014527	3553	Chemical	Gene	START_ENTITY|dobj|Production Production|compound|END_ENTITY	Rebamipide Suppresses Monosodium_Urate Crystal-Induced Interleukin-1b Production Through Regulation of Oxidative Stress and Caspase-1 in THP-1 Cells .
26872603	0	Monosodium_Urate	0,16	P2Y14_Receptor	58,72	Monosodium Urate	P2Y14 Receptor	MESH:D014527	9934	Chemical	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	Monosodium_Urate Crystals Induce Functional Expression of P2Y14_Receptor in Human Keratinocytes .
22978669	0	Monosodium_glutamate	0,20	glucagon-like_peptide-1	45,68	Monosodium glutamate	glucagon-like peptide-1	CHEBI:64243	2641	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|nmod|END_ENTITY	Monosodium_glutamate stimulates secretion of glucagon-like_peptide-1 and reduces postprandial glucose after a lipid-containing meal .
6114783	0	Monosodium_glutamate	0,20	growth_hormone	60,74	Monosodium glutamate	growth hormone	CHEBI:64243	81668(Tax:10116)	Chemical	Gene	START_ENTITY|dep|effects effects|nmod|END_ENTITY	Monosodium_glutamate : acute and chronic effects on rhythmic growth_hormone and prolactin secretion , and somatostatin in the undisturbed male rat .
9627105	0	Monosodium_glutamate	0,20	growth_hormone	70,84	Monosodium glutamate	growth hormone	CHEBI:64243	81668(Tax:10116)	Chemical	Gene	lesions|amod|START_ENTITY inhibit|nsubj|lesions inhibit|dobj|END_ENTITY	Monosodium_glutamate lesions inhibit the N-methyl-D-aspartate-induced growth_hormone but not prolactin release in rats .
16668790	0	Monoterpenoids	65,79	Cytochrome_P-450	43,59	Monoterpenoids	Cytochrome P-450	MESH:D039821	4051	Chemical	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of Avocado -LRB- Persea americana -RRB- Cytochrome_P-450 with Monoterpenoids .
22986158	0	Montelukast	0,11	caspase-3	21,30	Montelukast	caspase-3	MESH:C093875	25402(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Montelukast inhibits caspase-3 activity and ameliorates oxidative damage in the spinal cord and urinary bladder of rats with spinal_cord_injury .
15452361	0	Montelukast	0,11	cysteinyl_leukotriene_receptor-1	15,47	Montelukast	cysteinyl leukotriene receptor-1	MESH:C093875	58861(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Montelukast , a cysteinyl_leukotriene_receptor-1 antagonist , dose - and time-dependently protects against focal cerebral_ischemia in mice .
21782947	0	Morin	0,5	GSK3b	56,61	Morin	GSK3b	MESH:C008548	2932	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|nmod|END_ENTITY	Morin attenuates tau hyperphosphorylation by inhibiting GSK3b .
25337552	0	Morin	0,5	Heme_Oxygenase-1	14,30	Morin	Heme Oxygenase-1	MESH:C008548	3162	Chemical	Gene	Induces|nsubj|START_ENTITY Induces|dobj|END_ENTITY	Morin Induces Heme_Oxygenase-1 via ERK-Nrf2 Signaling Pathway .
23215787	0	Morphine	0,8	Argonaute_2	48,59	Morphine	Argonaute 2	MESH:D009020	100362151	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|factors factors|amod|END_ENTITY	Morphine administration modulates expression of Argonaute_2 and dopamine-related transcription factors involved in midbrain dopaminergic neurons function .
23927484	0	Morphine	0,8	Argonaute_2	19,30	Morphine	Argonaute 2	MESH:D009020	100362151	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Morphine regulates Argonaute_2 and TH expression and activity but not miR-133b in midbrain dopaminergic neurons .
17156455	0	Morphine	0,8	CCL2	20,24	Morphine	CCL2	MESH:D009020	6347	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|compound|END_ENTITY	Morphine stimulates CCL2 production by human neurons .
20578038	0	Morphine	0,8	CCL5	32,36	Morphine	CCL5	MESH:D009020	6352	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|release release|nmod|END_ENTITY	Morphine induces the release of CCL5 from astrocytes : potential neuroprotective mechanism against the HIV protein gp120 .
10887175	0	Morphine	0,8	CCR5	36,40	Morphine	CCR5	MESH:D009020	1234	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Morphine induces gene expression of CCR5 in human CEMx174 lymphocytes .
1545011	0	Morphine	0,8	Fos	32,35	Morphine	Fos	MESH:D009020	314322(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|immunoreactivity immunoreactivity|compound|END_ENTITY	Morphine or U-50 ,488 suppresses Fos protein-like immunoreactivity in the spinal cord and nucleus tractus solitarii evoked by a noxious visceral stimulus in the rat .
18485622	0	Morphine	0,8	Fos	71,74	Morphine	Fos	MESH:D009020	314322(Tax:10116)	Chemical	Gene	pre-exposures|compound|START_ENTITY modify|nsubj|pre-exposures modify|dobj|expression expression|amod|END_ENTITY	Morphine and methadone pre-exposures differently modify brain regional Fos protein expression and locomotor activity responses to morphine challenge in the rat .
17380193	0	Morphine	0,8	IL-10	32,37	Morphine	IL-10	MESH:D009020	3586	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|amod|END_ENTITY	Morphine reciprocally regulates IL-10 and IL-12 production by monocyte-derived human dendritic cells and enhances T cell activation .
9259765	0	Morphine	0,8	IL-2	48,52	Morphine	IL-2	MESH:D009020	16183(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	Morphine inhibits transcriptional activation of IL-2 in mouse thymocytes .
21245149	0	Morphine	0,8	IL-23	40,45	Morphine	IL-23	MESH:D009020	83430(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	Morphine inhibits murine dendritic cell IL-23 production by modulating Toll-like_receptor_2 and Nod2 signaling .
26078009	0	Morphine	0,8	Interleukin-4	19,32	Morphine	Interleukin-4	MESH:D009020	16189(Tax:10090)	Chemical	Gene	Modulates|nsubj|START_ENTITY Modulates|dobj|END_ENTITY	Morphine Modulates Interleukin-4 - or Breast_Cancer Cell-induced Pro-metastatic Activation of Macrophages .
26626290	0	Morphine	73,81	JNK	106,109	Morphine	JNK	MESH:D009020	26419(Tax:10090)	Chemical	Gene	Tolerance|compound|START_ENTITY Tolerance|nmod|END_ENTITY	Opening of Adenosine_Triphosphate-Sensitive Potassium Channel Attenuates Morphine Tolerance by Inhibiting JNK and Astrocyte Activation in the Spinal Cord .
8255183	0	Morphine	0,8	LHRH	96,100	Morphine	LHRH	MESH:D009020	25194(Tax:10116)	Chemical	Gene	norepinephrine|amod|START_ENTITY norepinephrine|dep|increases increases|nmod|levels levels|compound|END_ENTITY	Morphine amplifies norepinephrine -LRB- NE -RRB- - induced LH release but blocks NE-stimulated increases in LHRH mRNA levels : comparison of responses obtained in ovariectomized , estrogen-treated normal and androgen-sterilized rats .
537466	0	Morphine	0,8	Met-enkephalin	35,49	Morphine	Met-enkephalin	MESH:D009020	5443	Chemical	Gene	like|nsubj|START_ENTITY like|dobj|activity activity|nmod|analogues analogues|amod|END_ENTITY	Morphine like activity of some new Met-enkephalin analogues .
23835420	0	Morphine	0,8	OCT1	58,62	Morphine	OCT1	MESH:D009020	6580	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Morphine is a substrate of the organic cation transporter OCT1 and polymorphisms in OCT1 gene affect morphine pharmacokinetics after codeine administration .
25938863	0	Morphine	45,53	P-Glycoprotein	99,113	Morphine	P-Glycoprotein	MESH:D009020	5243	Chemical	Gene	Sites|nmod|START_ENTITY Sites|nmod|END_ENTITY	Identification of Possible Binding Sites for Morphine and Nicardipine on the Multidrug Transporter P-Glycoprotein Using Umbrella Sampling Techniques .
19912904	0	Morphine	97,105	Pro-opiomelanocortin	56,76	Morphine	Pro-opiomelanocortin	MESH:D009020	5443	Chemical	Gene	Exposure|compound|START_ENTITY Activation|nmod|Exposure Activation|nmod|mRNA mRNA|amod|END_ENTITY	Prolonged Activation of c-fos and Optimal Activation of Pro-opiomelanocortin mRNA after Repeated Morphine Exposure in SH-SY5Y Cells .
11106302	0	Morphine	0,8	RANTES	78,84	Morphine	RANTES	MESH:D009020	6352	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|nmod|END_ENTITY	Morphine inhibits human microglial cell production of , and migration towards , RANTES .
22160839	0	Morphine	0,8	T-bet	89,94	Morphine	T-bet	MESH:D009020	30009	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|nmod|END_ENTITY	Morphine , but not ketamine , decreases the ratio of Th1/Th2 in CD4-positive cells through T-bet and GATA3 .
19071087	0	Morphine	0,8	TLR2	32,36	Morphine	TLR2	MESH:D009020	7097	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|apoptosis apoptosis|nmod|END_ENTITY	Morphine promotes apoptosis via TLR2 , and this is negatively regulated by beta-arrestin_2 .
10921509	0	Morphine	0,8	TNF-alpha	35,44	Morphine	TNF-alpha	MESH:D009020	7124	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Morphine stimulates mesangial cell TNF-alpha and nitrite production .
15913793	0	Morphine	0,8	TNF-alpha	68,77	Morphine	TNF-alpha	MESH:D009020	21926(Tax:10090)	Chemical	Gene	withdrawal|amod|START_ENTITY sensitizes|nsubj|withdrawal sensitizes|xcomp|lipopolysaccharide lipopolysaccharide|dobj|END_ENTITY	Morphine withdrawal sensitizes mice to lipopolysaccharide : elevated TNF-alpha and nitric_oxide with decreased IL-12 .
24850983	0	Morphine	0,8	TRPV1	31,36	Morphine	TRPV1	MESH:D009020	83810(Tax:10116)	Chemical	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	Morphine Reduces Expression of TRPV1 Receptors in the Amygdala but not in the Hippocampus of Male Rats .
12947338	0	Morphine	0,8	VEGF	18,22	Morphine	VEGF	MESH:D009020	83785(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Morphine inhibits VEGF expression in myocardial_ischemia .
12814374	0	Morphine	0,8	c-Fos	95,100	Morphine	c-Fos	MESH:D009020	314322(Tax:10116)	Chemical	Gene	withdrawal|amod|START_ENTITY precipitated|nsubj|withdrawal precipitated|nmod|antagonists antagonists|dep|study study|amod|END_ENTITY	Morphine withdrawal precipitated by specific mu , delta or kappa opioid receptor antagonists : a c-Fos protein study in the rat central nervous system .
14725964	0	Morphine	0,8	c-Fos	30,35	Morphine	c-Fos	MESH:D009020	314322(Tax:10116)	Chemical	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Morphine - and cocaine-induced c-Fos levels in Lewis and Fischer rat strains .
10692604	0	Morphine	0,8	c-fos	45,50	Morphine	c-fos	MESH:D009020	314322(Tax:10116)	Chemical	Gene	reduce|nsubj|START_ENTITY reduce|dobj|expression expression|amod|END_ENTITY	Morphine and NMDA receptor antagonism reduce c-fos expression in spinal trigeminal nucleus produced by acute injury to the TMJ region .
12358736	0	Morphine	0,8	c-fos	28,33	Morphine	c-fos	MESH:D009020	314322(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Morphine withdrawal-induced c-fos expression in the hypothalamic paraventricular nucleus is dependent on the activation of catecholaminergic neurones .
12809699	0	Morphine	0,8	c-fos	22,27	Morphine	c-fos	MESH:D009020	314322(Tax:10116)	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|expression expression|amod|END_ENTITY	Morphine induction of c-fos expression in the rat forebrain through glutamatergic mechanisms : role of non-n-methyl-D-aspartate receptors .
15033383	0	Morphine	0,8	c-fos	28,33	Morphine	c-fos	MESH:D009020	314322(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Morphine withdrawal-induced c-fos expression in the heart : a peripheral mechanism .
17675197	0	Morphine	0,8	c-fos	24,29	Morphine	c-fos	MESH:D009020	100144486(Tax:9823)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|iobj|END_ENTITY	Morphine reduces spinal c-fos expression dose-dependently during experimental laparotomy in pigs : a combined pharmacokinetic and surgical study .
19912904	0	Morphine	97,105	c-fos	24,29	Morphine	c-fos	MESH:D009020	2353	Chemical	Gene	Exposure|compound|START_ENTITY Activation|nmod|Exposure Activation|nmod|END_ENTITY	Prolonged Activation of c-fos and Optimal Activation of Pro-opiomelanocortin mRNA after Repeated Morphine Exposure in SH-SY5Y Cells .
3144275	0	Morphine	0,8	c-fos	23,28	Morphine	c-fos	MESH:D009020	314322(Tax:10116)	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|expression expression|amod|END_ENTITY	Morphine activation of c-fos expression in rat brain .
7614003	0	Morphine	0,8	c-fos	54,59	Morphine	c-fos	MESH:D009020	314322(Tax:10116)	Chemical	Gene	reduce|advmod|START_ENTITY reduce|dobj|expression expression|amod|END_ENTITY	Morphine , 5-HT2 and 5-HT3 receptor antagonists reduce c-fos expression in the trigeminal nuclear complex following noxious chemical stimulation of the rat nasal mucosa .
7624831	5	Morphine	731,739	c-fos	760,765	Morphine	c-fos	MESH:D009020	314322(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY increased|nsubj|treatment increased|dobj|levels levels|amod|END_ENTITY	Morphine treatment increased c-fos mRNA levels in striatum -LRB- STR -RRB- and amygdala -LRB- AMY -RRB- .
8078918	0	Morphine	0,8	c-fos	17,22	Morphine	c-fos	MESH:D009020	2353	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Morphine induces c-fos and junB in striatum and nucleus accumbens via D1 and N-methyl-D-aspartate receptors .
9070758	0	Morphine	0,8	c-fos	42,47	Morphine	c-fos	MESH:D009020	314322(Tax:10116)	Chemical	Gene	reduce|nsubj|START_ENTITY reduce|dobj|expression expression|amod|END_ENTITY	Morphine and somatostatin analogue reduce c-fos expression in trigeminal subnucleus caudalis produced by corneal stimulation in the rat .
7705887	0	Morphine	0,8	cathepsin_B	19,30	Morphine	cathepsin B	MESH:D009020	1508	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activity activity|amod|END_ENTITY	Morphine modulates cathepsin_B and L activity in isolated glomeruli and mesangial cells .
1847734	0	Morphine	0,8	enkephalin	40,50	Morphine	enkephalin	MESH:D009020	29237(Tax:10116)	Chemical	Gene	and|compound|START_ENTITY and|dep|increase increase|compound|END_ENTITY	Morphine and -LRB- D-Ala2 , NMe-Phe4 , Gly-ol -RRB- - enkephalin increase the intracellular free calcium in isolated rat myocytes -- effect of naloxone or pretreatment with morphine .
7110115	0	Morphine	0,8	enkephalin	61,71	Morphine	enkephalin	MESH:D009020	29237(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Morphine allosterically modulates the binding of -LSB- 3H -RSB- leucine enkephalin to a particulate fraction of rat brain .
9134231	14	Morphine	1644,1652	enkephalin	1695,1705	Morphine	enkephalin	MESH:D009020	29237(Tax:10116)	Chemical	Gene	gly|nsubj|START_ENTITY gly|parataxis|inhibited inhibited|nsubj|END_ENTITY	Morphine -LRB- 1 microM -RRB- and -LSB- D-Ala2 , MePhe4 , gly -LRB- ol -RRB- 5 -RSB- - enkephalin -LRB- DAMGO , 1 microM -RRB- also inhibited forskolin -LRB- 1 microM -RRB- - stimulated cyclic_AMP formation , whilst -LSB- D-Pen2 , D-Pen5 -RSB- , enkephalin -LRB- DPDPE , 1 microM -RRB- did not .
17562399	0	Morphine	0,8	hsp90beta	34,43	Morphine	hsp90beta	MESH:D009020	301252(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Morphine differentially regulates hsp90beta expression in the nucleus accumbens of Lewis and Fischer 344 rats .
12604012	0	Morphine	0,8	iNOS	20,24	Morphine	iNOS	MESH:D009020	4843	Chemical	Gene	stimulates|amod|START_ENTITY END_ENTITY|nsubj|stimulates	Morphine stimulates iNOS expression via a rebound from inhibition in human macrophages : nitric_oxide involvement .
12842891	0	Morphine	0,8	interferon-gamma	30,46	Morphine	interferon-gamma	MESH:D009020	15978(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	Morphine negatively regulates interferon-gamma promoter activity in activated murine T cells through two distinct cyclic_AMP-dependent pathways .
24302561	0	Morphine	0,8	miR-107	162,169	Morphine	miR-107	MESH:D009020	406901	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	Morphine regulates expression of - opioid receptor MOR-1A , an intron-retention carboxyl terminal splice variant of the - opioid receptor -LRB- OPRM1 -RRB- gene via miR-103 / miR-107 .
10672987	3	Morphine	510,518	mu-opiate_receptor	522,540	Morphine	mu-opiate receptor	MESH:D009020	29256(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Morphine , a mu-opiate_receptor agonist -LRB- 1.0 mg/kg IP -RRB- , potentiated the chloroquine-induced rat body scratching to 40 + / -6.6 , while the mu-opiate_receptor antagonist , naltrexone -LRB- 0.25 mg/kg , IP , given 15 min prior -RRB- blocked the chloroquine induced body scratching to 4.5 + / -2 -LRB- p < 0.05 ANOVA -RRB- .
10394089	0	Morphine	0,8	oxytocin	24,32	Morphine	oxytocin	MESH:D009020	5020	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|response response|compound|END_ENTITY	Morphine suppresses the oxytocin response in breast-feeding women .
6291011	0	Morphine	0,8	oxytocin	61,69	Morphine	oxytocin	MESH:D009020	18429(Tax:10090)	Chemical	Gene	inhibit|advmod|START_ENTITY inhibit|dobj|release release|compound|END_ENTITY	Morphine , beta-endorphin and -LSB- D-Ala2 -RSB- _ Met-enkephalin inhibit oxytocin release by acetylcholine and suckling .
2393216	0	Morphine	0,8	prodynorphin	17,29	Morphine	prodynorphin	MESH:D009020	29190(Tax:10116)	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|expression expression|compound|END_ENTITY	Morphine affects prodynorphin gene expression in some areas of rat brain .
3754583	0	Morphine	0,8	prolactin	20,29	Morphine	prolactin	MESH:D009020	24683(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|compound|END_ENTITY	Morphine stimulates prolactin release in normal but not in castrated male rats .
6514937	0	Morphine	0,8	prolactin	42,51	Morphine	prolactin	MESH:D009020	5617	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|compound|END_ENTITY	Morphine inhibits cortisol and stimulates prolactin secretion in man .
11104584	0	Morphine	0,8	substance_P	36,47	Morphine	substance P	MESH:D009020	6863	Chemical	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Morphine Up-regulates expression of substance_P and its receptor in human blood mononuclear phagocytes and lymphocytes .
8389331	0	Morphine	0,8	tumor_necrosis_factor	33,54	Morphine	tumor necrosis factor	MESH:D009020	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|nmod|END_ENTITY	Morphine inhibits the release of tumor_necrosis_factor in human peripheral blood mononuclear cell cultures .
11735263	0	Morphine_sulfate	0,16	vascular_endothelial_growth_factor	42,76	Morphine sulfate	vascular endothelial growth factor	MESH:D009020	7422	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Morphine_sulfate inhibits hypoxia-induced vascular_endothelial_growth_factor expression in endothelial cells and cardiac myocytes .
12107722	0	Mosapride	0,9	5HT-4	13,18	Mosapride	5HT-4	MESH:C062720	3360	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Mosapride , a 5HT-4 receptor agonist , improves insulin sensitivity and glycaemic control in patients with Type_II_diabetes mellitus .
12107722	0	Mosapride	0,9	insulin	46,53	Mosapride	insulin	MESH:C062720	3630	Chemical	Gene	improves|nsubj|START_ENTITY improves|dobj|sensitivity sensitivity|compound|END_ENTITY	Mosapride , a 5HT-4 receptor agonist , improves insulin sensitivity and glycaemic control in patients with Type_II_diabetes mellitus .
17012372	0	Moxifloxacin	0,12	JNK	92,95	Moxifloxacin	JNK	MESH:C104727	5599	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Moxifloxacin but not ciprofloxacin or azithromycin selectively inhibits IL-8 , IL-6 , ERK1/2 , JNK , and NF-kappaB activation in a cystic fibrosis epithelial cell line .
10807960	0	Moxonidine	0,10	imidazoline-1_receptor	24,46	Moxonidine	imidazoline-1 receptor	MESH:C043482	306255(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Moxonidine , a selective imidazoline-1_receptor agonist , suppresses the effects of ethanol withdrawal on the acoustic startle response in rats .
10489096	0	Moxonidine	0,10	insulin	20,27	Moxonidine	insulin	MESH:C043482	3630	Chemical	Gene	improves|nsubj|START_ENTITY improves|dobj|sensitivity sensitivity|compound|END_ENTITY	Moxonidine improves insulin sensitivity in insulin-resistant hypertensives .
2852302	0	Mu	13,15	Shrunken_1	25,35	Mu	Shrunken 1	null	542365(Tax:4577)	Chemical	Gene	START_ENTITY|nmod|gene gene|amod|END_ENTITY	Insertion of Mu into the Shrunken_1 gene of maize affects transcriptional and post-transcriptional regulation of Sh1 RNA .
1332851	0	Mu	0,2	prolactin	41,50	Mu	prolactin	null	24683(Tax:10116)	Chemical	Gene	control|amod|START_ENTITY control|nmod|secretion secretion|compound|END_ENTITY	Mu - and kappa-opiate receptor control of prolactin secretion in rats : ontogeny and interaction with serotonin .
9415803	0	Multiprotein	0,12	c-myc	38,43	Multiprotein	c-myc	null	4609	Chemical	Gene	START_ENTITY|nmod|promoter promoter|amod|END_ENTITY	Multiprotein complex formation on the c-myc promoter .
25971966	0	Multivitamin	48,60	hSMVT	74,79	Multivitamin	hSMVT	null	8884	Chemical	Gene	Transporter|compound|START_ENTITY Transporter|appos|END_ENTITY	Interaction of a-Lipoic_Acid with the Human Na + / Multivitamin Transporter -LRB- hSMVT -RRB- .
25278013	0	Muramyl_Dipeptide	12,29	Interleukin-10	60,74	Muramyl Dipeptide	Interleukin-10	MESH:D000119	3586	Chemical	Gene	Associated|nsubj|START_ENTITY Associated|nmod|END_ENTITY	Circulating Muramyl_Dipeptide Is Negatively Associated with Interleukin-10 in the Frail Elderly .
25429073	0	Muramyl_Dipeptide	101,118	NOD2	72,76	Muramyl Dipeptide	NOD2	MESH:D000119	257632(Tax:10090)	Chemical	Gene	Nod2|nmod|START_ENTITY Nod2|dobj|Expression Expression|nmod|END_ENTITY	Blau Syndrome-Associated Nod2 Mutation Alters Expression of Full-Length NOD2 and Limits Responses to Muramyl_Dipeptide in Knock-in Mice .
26226896	0	Muramyl_Dipeptide	35,52	NOD2	99,103	Muramyl Dipeptide	NOD2	MESH:D000119	64127	Chemical	Gene	Derivatives|compound|START_ENTITY Synthesis|nmod|Derivatives Synthesis|nmod|Study Study|nmod|Activity Activity|compound|END_ENTITY	Synthesis of Diverse N-Substituted Muramyl_Dipeptide Derivatives and Their Use in a Study of Human NOD2 Stimulation Activity .
22590599	0	Muramyl_dipeptide	0,17	Ly6C	41,45	Muramyl dipeptide	Ly6C	MESH:D000119	17067(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Muramyl_dipeptide induces NOD2-dependent Ly6C -LRB- high -RRB- monocyte recruitment to the lungs and protects against influenza_virus_infection .
23275943	0	Muramyl_dipeptide	0,17	NOD2	63,67	Muramyl dipeptide	NOD2	MESH:D000119	64127	Chemical	Gene	responsive|compound|START_ENTITY pathways|nsubj|responsive pathways|nmod|END_ENTITY	Muramyl_dipeptide responsive pathways in Crohn 's _ disease : from NOD2 and beyond .
25467233	0	Muramyl_dipeptide	0,17	beta_defensin_2	34,49	Muramyl dipeptide	beta defensin 2	MESH:D000119	1673	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Muramyl_dipeptide activates human beta_defensin_2 and pro-inflammatory mediators through Toll-like receptors and NLRP3 inflammasomes in human dental pulp cells .
18188453	0	Muramyl_dipeptide	0,17	nucleotide-binding_oligomerization_domain_2	32,75	Muramyl dipeptide	nucleotide-binding oligomerization domain 2	MESH:D000119	257632(Tax:10090)	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Muramyl_dipeptide activation of nucleotide-binding_oligomerization_domain_2 protects mice from experimental colitis .
18647246	0	Muramyldipeptide	0,16	CXCL-8	27,33	Muramyldipeptide	CXCL-8	MESH:D000119	3576	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|release release|compound|END_ENTITY	Muramyldipeptide modulates CXCL-8 release of BEAS-2B cells via NOD2 .
12191495	0	Muscarine	0,9	amyloid_precursor_protein	27,52	Muscarine	amyloid precursor protein	MESH:D009116	351	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|secretion secretion|compound|END_ENTITY	Muscarine enhances soluble amyloid_precursor_protein secretion in human neuroblastoma SH-SY5Y by a pathway dependent on protein kinase C -LRB- alpha -RRB- , src-tyrosine kinase and extracellular signal-regulated kinase but not phospholipase C .
25976179	0	Muscone	11,18	P-gp	40,44	Muscone	P-gp	MESH:C031021	5243	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of Muscone on the Expression of P-gp , MMP-9 on Blood-Brain Barrier Model In Vitro .
26293053	0	Mycophenolate_Mofetil	93,114	NKG2D	40,45	Mycophenolate Mofetil	NKG2D	MESH:C063008	22914	Chemical	Gene	Effect|nmod|START_ENTITY Involved|nmod|Effect Involved|nsubjpass|END_ENTITY	Natural Killer Cell Activating Receptor NKG2D Is Involved in the Immunosuppressant Effect of Mycophenolate_Mofetil and Infection of Hepatitis_B_Virus .
15654821	0	Mycophenolate_mofetil	0,21	cyclin	47,53	Mycophenolate mofetil	cyclin	MESH:C063008	25737(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|expression expression|compound|END_ENTITY	Mycophenolate_mofetil and roscovitine decrease cyclin expression and increase p27 -LRB- kip1 -RRB- expression in anti Thy1 mesangial proliferative nephritis .
19328959	0	Mycophenolic_Acid	0,17	p38_Mitogen-Activated_Protein_Kinase	27,63	Mycophenolic Acid	p38 Mitogen-Activated Protein Kinase	MESH:D009173	1432	Chemical	Gene	Inhibits|nsubj|START_ENTITY Inhibits|xcomp|END_ENTITY	Mycophenolic_Acid Inhibits p38_Mitogen-Activated_Protein_Kinase in Human Monocyte-Derived Dendritic Cells Stimulated by Lipopolysaccharide .
22005457	0	Mycophenolic_acid	0,17	ATP-binding_cassette_transporter_A1	26,61	Mycophenolic acid	ATP-binding cassette transporter A1	MESH:D009173	19	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Mycophenolic_acid induces ATP-binding_cassette_transporter_A1 -LRB- ABCA1 -RRB- expression through the PPARy-LXRa-ABCA1 pathway .
16797370	0	Mycophenolic_acid	0,17	B7-DC	30,35	Mycophenolic acid	B7-DC	MESH:D009173	58205(Tax:10090)	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	Mycophenolic_acid upregulates B7-DC expression on dendritic cells , which is associated with impaired allostimulatory capacity of dendritic cells .
19578979	0	Mycophenolic_acid	0,17	MCP-1	43,48	Mycophenolic acid	MCP-1	MESH:D009173	6347	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Mycophenolic_acid inhibits albumin-induced MCP-1 expression in renal tubular epithelial cells through the p38_MAPK pathway .
20302854	0	Mycophenolic_acid	0,17	NF-kappaB	50,59	Mycophenolic acid	NF-kappaB	MESH:D009173	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Mycophenolic_acid inhibits the phosphorylation of NF-kappaB and JNKs and causes a decrease in IL-8 release in H2O2-treated human renal proximal tubular cells .
18723570	0	Mycophenolic_acid	0,17	PDGF-B	41,47	Mycophenolic acid	PDGF-B	MESH:D009173	24628(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|synthesis synthesis|amod|END_ENTITY	Mycophenolic_acid inhibits the autocrine PDGF-B synthesis and PDGF-BB-induced mRNA expression of Egr-1 in rat mesangial cells .
17618115	0	Mycophenolic_acid	0,17	PPARgamma	41,50	Mycophenolic acid	PPARgamma	MESH:D009173	5468	Chemical	Gene	START_ENTITY|nmod|agonist agonist|nmod|END_ENTITY	Mycophenolic_acid as a latent agonist of PPARgamma .
20138622	0	Mycophenolic_acid	0,17	endothelin-1	65,77	Mycophenolic acid	endothelin-1	MESH:D009173	1906	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|production production|amod|END_ENTITY	Mycophenolic_acid attenuates tumor_necrosis_factor-alpha-induced endothelin-1 production in human aortic endothelial cells .
18305114	0	Mycophenolic_acid	0,17	p53	32,35	Mycophenolic acid	p53	MESH:D009173	7157	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Mycophenolic_acid activation of p53 requires ribosomal proteins L5 and L11 .
7535576	0	Myelin	0,6	CSF	33,36	Myelin	CSF	null	1437	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Myelin degrading activity in the CSF of HIV-1-infected patients with neurological_diseases .
10517498	0	Myelopoietin	0,12	interleukin_3	42,55	Myelopoietin	interleukin 3	MESH:C404145	3562	Chemical	Gene	START_ENTITY|appos|agonist agonist|nmod|END_ENTITY	Myelopoietin , a chimeric agonist of human interleukin_3 and granulocyte_colony-stimulating_factor receptors , mobilizes CD34 + cells that rapidly engraft lethally x-irradiated nonhuman primates .
19759331	0	Myostatin	0,9	Akt	61,64	Myostatin	Akt	MESH:D055435	11651(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Myostatin inhibits IGF-I-induced myotube_hypertrophy through Akt .
15183844	0	Myostatin	0,9	Smad2	28,33	Myostatin	Smad2	MESH:D055435	4087	Chemical	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Myostatin signaling through Smad2 , Smad3 and Smad4 is regulated by the inhibitory Smad7 by a negative feedback mechanism .
15183844	0	Myostatin	0,9	Smad7	82,87	Myostatin	Smad7	MESH:D055435	4092	Chemical	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Myostatin signaling through Smad2 , Smad3 and Smad4 is regulated by the inhibitory Smad7 by a negative feedback mechanism .
26086422	0	Myostatin	0,9	follistatin	11,22	Myostatin	follistatin	MESH:D055435	10468	Chemical	Gene	expressed|advcl|START_ENTITY expressed|nsubjpass|receptors receptors|compound|END_ENTITY	Myostatin , follistatin and activin type II receptors are highly expressed in adenomyosis .
25869071	0	Myostatin	0,9	miR-431	20,27	Myostatin	miR-431	MESH:D055435	723866(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Myostatin regulates miR-431 expression via the Ras-Mek-Erk signaling pathway .
24569980	0	Myricetin	0,9	COX-2	43,48	Myricetin	COX-2	MESH:C040015	5743	Chemical	Gene	blocks|nsubj|START_ENTITY blocks|dobj|expression expression|compound|END_ENTITY	Myricetin blocks lipoteichoic_acid-induced COX-2 expression in human gingival fibroblasts .
18995957	0	Myricetin	0,9	JAK1	27,31	Myricetin	JAK1	MESH:C040015	16451(Tax:10090)	Chemical	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Myricetin directly targets JAK1 to inhibit cell transformation .
26104578	0	Myricetin	0,9	P21_activated_kinase_1	42,64	Myricetin	P21 activated kinase 1	MESH:C040015	5058	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Myricetin induces apoptosis by inhibiting P21_activated_kinase_1 -LRB- PAK1 -RRB- signaling cascade in hepatocellular_carcinoma .
17113042	0	Myricetin	0,9	bone_morphogenetic_protein-2	59,87	Myricetin	bone morphogenetic protein-2	MESH:C040015	650	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|pathway pathway|amod|END_ENTITY	Myricetin induces human osteoblast differentiation through bone_morphogenetic_protein-2 / p38 mitogen-activated protein kinase pathway .
15713899	0	Myricetin	0,9	matrix_metalloproteinase_2	19,45	Myricetin	matrix metalloproteinase 2	MESH:C040015	4313	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Myricetin inhibits matrix_metalloproteinase_2 protein expression and enzyme activity in colorectal_carcinoma cells .
17113042	0	Myricetin	0,9	p38	88,91	Myricetin	p38	MESH:C040015	1432	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|pathway pathway|amod|END_ENTITY	Myricetin induces human osteoblast differentiation through bone_morphogenetic_protein-2 / p38 mitogen-activated protein kinase pathway .
17963707	0	Myricitrin	0,10	myeloperoxidase	43,58	Myricitrin	myeloperoxidase	MESH:C008577	4353	Chemical	Gene	START_ENTITY|nmod|substrate substrate|nmod|END_ENTITY	Myricitrin as a substrate and inhibitor of myeloperoxidase : implications for the pharmacological effects of flavonoids .
15270551	0	Myristic_acid	0,13	delta6-desaturase	24,41	Myristic acid	delta6-desaturase	MESH:D019814	83512(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|activity activity|amod|END_ENTITY	Myristic_acid increases delta6-desaturase activity in cultured rat hepatocytes .
15970594	0	Myristic_acid	0,13	endothelial_nitric-oxide_synthase	25,58	Myristic acid	endothelial nitric-oxide synthase	MESH:D019814	4846	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Myristic_acid stimulates endothelial_nitric-oxide_synthase in a CD36 - and an AMP kinase-dependent manner .
26528796	0	Myristoleic_acid	0,16	RANKL	86,91	Myristoleic acid	RANKL	MESH:C054211	21943(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|suppressing suppressing|dobj|activation activation|amod|END_ENTITY	Myristoleic_acid inhibits osteoclast formation and bone resorption by suppressing the RANKL activation of Src and Pyk2 .
15632291	0	Myristoyl	0,9	Nef	24,27	Myristoyl	Nef	CHEBI:25456	6285	Chemical	Gene	moiety|amod|START_ENTITY moiety|nmod|END_ENTITY	Myristoyl moiety of HIV Nef is involved in regulation of the interaction with calmodulin in vivo .
15802853	0	Myrothenones_A_and_B	0,20	tyrosinase	54,64	Myrothenones A and B	tyrosinase	null	7299	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Myrothenones_A_and_B , cyclopentenone derivatives with tyrosinase inhibitory activity from the marine-derived fungus Myrothecium sp .
14680815	0	N	5,6	ERalpha	62,69	N	ERalpha	null	2099	Chemical	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	Both N - and C-terminal transactivation functions of DNA-bound ERalpha are blocked by a novel synthetic estrogen ligand .
16891553	0	N	44,45	ETR1	39,43	N	ETR1	null	842951(Tax:3702)	Chemical	Gene	terminus|compound|START_ENTITY terminus|compound|END_ENTITY	Receptor signal output mediated by the ETR1 N terminus is primarily subfamily I receptor dependent .
23792105	0	N	23,24	H-RAS	27,32	N	H-RAS	null	3265	Chemical	Gene	-|compound|START_ENTITY -|appos|END_ENTITY	Rapid detection of K - , N - , H-RAS , and BRAF hotspot mutations in thyroid_cancer using the multiplex primer extension .
20631090	0	N	52,53	HAX-1	77,82	N	HAX-1	null	10456	Chemical	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	The classical_swine_fever_virus N-terminal protease N -LRB- pro -RRB- binds to cellular HAX-1 .
11298772	0	N	9,10	Hsp90	46,51	N	Hsp90	null	3320	Chemical	Gene	sites|amod|START_ENTITY sites|nmod|END_ENTITY	Both the N - and C-terminal chaperone sites of Hsp90 participate in protein refolding .
25679754	0	N	44,45	Hsp90	61,66	N	Hsp90	null	3320	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Combining an Hsp70 inhibitor with either an N - or C-terminal Hsp90 inhibitor produces mechanistically distinct phenotypes .
24029017	0	N	27,28	IF2	23,26	N	IF2	null	9669	Chemical	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	Involvement of protein IF2 N domain in ribosomal subunit joining revealed from architecture and function of the full-length initiation factor .
9763623	0	N	37,38	Kvbeta1	27,34	N	Kvbeta1	null	7881	Chemical	Gene	effects|dep|START_ENTITY effects|nmod|END_ENTITY	Separable effects of human Kvbeta1 .2 N - and C-termini on inactivation and expression of human Kv1 .4 .
17568194	0	N	24,25	PP6	20,23	N	PP6	null	5537	Chemical	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	Protein phosphatase PP6 N terminal domain restricts G1 to S phase progression in human cancer cells .
9185547	7	N	1024,1025	PS1	1020,1023	N	PS1	null	5663	Chemical	Gene	terminus|compound|START_ENTITY terminus|compound|END_ENTITY	About 30 % of hippocampal NFTs are labeled with a highly specific antibody to the PS1 C-terminal loop domain but not with an antibody to the PS1 N terminus .
19074551	0	N	53,54	PTEN	15,19	N	PTEN	null	5728	Chemical	Gene	suppression|nmod|START_ENTITY suppression|compound|END_ENTITY	FoxO1 mediates PTEN suppression of androgen_receptor N - and C-terminal interactions and coactivator recruitment .
23288847	0	N	54,55	S-adenosylmethionine_decarboxylase	19,53	N	S-adenosylmethionine decarboxylase	null	262	Chemical	Gene	terminus|compound|START_ENTITY terminus|compound|END_ENTITY	Trypanosoma_brucei S-adenosylmethionine_decarboxylase N terminus is essential for allosteric activation by the regulatory subunit prozyme .
17229728	0	N	8,9	SMG-1	80,85	N	SMG-1	null	23049	Chemical	Gene	required|nsubjpass|START_ENTITY required|nmod|activity activity|nmod|END_ENTITY	Distant N - and C-terminal domains are required for intrinsic kinase activity of SMG-1 , a critical component of nonsense-mediated_mRNA_decay .
12150996	0	N	37,38	TBP	33,36	N	TBP	null	6908	Chemical	Gene	terminus|compound|START_ENTITY terminus|compound|END_ENTITY	Removing the vertebrate-specific TBP N terminus disrupts placental beta2m-dependent interactions with the maternal immune system .
15064981	0	N	4,5	Tat2	55,59	N	Tat2	null	854139(Tax:4932)	Chemical	Gene	mutations|amod|START_ENTITY mutations|nmod|END_ENTITY	The N - and C-terminal mutations in tryptophan permease Tat2 confer cell growth in Saccharomyces_cerevisiae under high-pressure and low-temperature conditions .
16352540	0	N	124,125	VP1	120,123	N	VP1	null	1489592(Tax:10794)	Chemical	Gene	terminus|compound|START_ENTITY terminus|compound|END_ENTITY	VP2 cleavage and the leucine ring at the base of the fivefold cylinder control pH-dependent externalization of both the VP1 N terminus and the genome of minute_virus_of_mice .
24173216	0	N	89,90	Vpx	113,116	N	Vpx	null	1490006(Tax:11723)	Chemical	Gene	START_ENTITY|dobj|proteins proteins|compound|END_ENTITY	Variation of two primate lineage-specific residues in human SAMHD1 confers resistance to N terminus-targeted SIV Vpx proteins .
24173216	0	N	89,90	Vpx	113,116	N	Vpx	null	1490006(Tax:11723)	Chemical	Gene	START_ENTITY|dobj|proteins proteins|compound|END_ENTITY	Variation of two primate lineage-specific residues in human SAMHD1 confers resistance to N terminus-targeted SIV Vpx proteins .
20826823	0	N	4,5	angiotensin-I-converting_enzyme	22,53	N	angiotensin-I-converting enzyme	null	1636	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	The N domain of human angiotensin-I-converting_enzyme : the role of N-glycosylation and the crystal structure in complex with an N domain-specific phosphinic inhibitor , RXP407 .
9570482	0	N	0,1	angiotensin_II	46,60	N	angiotensin II	null	183	Chemical	Gene	START_ENTITY|dep|study study|nmod|END_ENTITY	N - and C-terminal structure-activity study of angiotensin_II on the angiotensin AT2 receptor .
22215717	0	N	53,54	angiotensin_II_type_2_receptor	7,37	N	angiotensin II type 2 receptor	null	24182(Tax:10116)	Chemical	Gene	stimulation|nmod|START_ENTITY stimulation|amod|END_ENTITY	Direct angiotensin_II_type_2_receptor stimulation in N - nitro-L-arginine-methyl_ester-induced hypertension : the effect on pulse wave velocity and aortic remodeling .
7737204	0	N	38,39	erythropoietin	95,109	N	erythropoietin	null	2056	Chemical	Gene	chains|amod|START_ENTITY analysis|nmod|chains analysis|nmod|END_ENTITY	Structural analysis of the sialylated N - and O-linked carbohydrate chains of recombinant human erythropoietin expressed in Chinese_hamster ovary cells .
15972328	0	N	88,89	gD	85,87	N	gD	null	2532	Chemical	Gene	terminus|compound|START_ENTITY terminus|compound|END_ENTITY	The pro-fusion_domain of herpes simplex virus glycoprotein_D -LRB- gD -RRB- interacts with the gD N terminus and is displaced by soluble forms of viral receptors .
20693282	2	N	281,282	hERG1	251,256	N	hERG1	null	3757	Chemical	Gene	isoforms|nmod|START_ENTITY isoforms|nsubj|END_ENTITY	Several hERG1 isoforms with different N - and C-terminal ends have been identified .
17536340	0	N,N-dialkyl-2-phenylindol-3-yl-glyoxylamides	73,117	peripheral_benzodiazepine_receptor	18,52	N,N-dialkyl-2-phenylindol-3-yl-glyoxylamides	peripheral benzodiazepine receptor	null	706	Chemical	Gene	affinity|nmod|START_ENTITY affinity|compound|END_ENTITY	Exploring QSAR of peripheral_benzodiazepine_receptor binding affinity of N,N-dialkyl-2-phenylindol-3-yl-glyoxylamides using physico-chemical descriptors .
19297158	0	N,N-dialkylbenzamidines	21,44	factor_Xa	79,88	N,N-dialkylbenzamidines	factor Xa	null	2159	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Anthranilamide-based N,N-dialkylbenzamidines as potent and orally bioavailable factor_Xa inhibitors : P4 SAR .
6719937	0	N,N-dimethylaniline	72,91	cytochrome_P-450	12,28	N,N-dimethylaniline	cytochrome P-450	MESH:C015157	25251(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of cytochrome_P-450 in the dual pathways of N-demethylation of N,N-dimethylaniline by hepatic microsomes .
24730580	0	N,N-dimethyltryptamine	68,90	indolethylamine-N-methyltransferase	29,64	N,N-dimethyltryptamine	indolethylamine-N-methyltransferase	MESH:D004130	11185	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Noncompetitive inhibition of indolethylamine-N-methyltransferase by N,N-dimethyltryptamine and N,N-dimethylaminopropyltryptamine .
7627127	0	N,S-bis-fluorenylmethoxycarbonylglutathione	0,43	glyoxalase_II	87,100	N,S-bis-fluorenylmethoxycarbonylglutathione	glyoxalase II	MESH:C094901	3029	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	N,S-bis-fluorenylmethoxycarbonylglutathione : a new , very potent inhibitor of mammalian glyoxalase_II .
3130270	0	N-0437	0,6	D-2	20,23	N-0437	D-2	MESH:C047508	29484(Tax:10116)	Chemical	Gene	START_ENTITY|dep|agonist agonist|amod|END_ENTITY	N-0437 : a selective D-2 dopamine receptor agonist in in vitro and in vivo models .
18556728	0	N-1-naphthyphthalamic_acid	88,114	AtABCB19	38,46	N-1-naphthyphthalamic acid	AtABCB19	null	822519(Tax:3702)	Chemical	Gene	effects|nmod|START_ENTITY involved|nmod|effects involved|nsubjpass|END_ENTITY	The ABC subfamily B auxin transporter AtABCB19 is involved in the inhibitory effects of N-1-naphthyphthalamic_acid on the phototropic and gravitropic responses of Arabidopsis hypocotyls .
18304819	0	N-1H-benzimidazol-5-ylbenzenesulfonamide	0,40	hPXR	63,67	N-1H-benzimidazol-5-ylbenzenesulfonamide	hPXR	MESH:C528601	8856	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	N-1H-benzimidazol-5-ylbenzenesulfonamide derivatives as potent hPXR agonists .
23853040	0	N-3-methoxybenzyl-linoleamide	13,42	FAAH	91,95	N-3-methoxybenzyl-linoleamide	FAAH	null	2166	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|appos|END_ENTITY	The macamide N-3-methoxybenzyl-linoleamide is a time-dependent fatty_acid_amide hydrolase -LRB- FAAH -RRB- inhibitor .
10753463	0	N-3-substituted_imidazoquinazolinones	0,37	PDE5	60,64	N-3-substituted imidazoquinazolinones	PDE5	null	8654	Chemical	Gene	START_ENTITY|dep|inhibitors inhibitors|compound|END_ENTITY	N-3-substituted_imidazoquinazolinones : potent and selective PDE5 inhibitors as potential agents for treatment of erectile_dysfunction .
20196964	0	N-3_fatty_acids	14,29	myeloperoxidase	40,55	N-3 fatty acids	myeloperoxidase	MESH:D015525	4353	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nsubj|effect	The effect of N-3_fatty_acids on plasma myeloperoxidase levels in healthy adults .
17600705	0	N-4-Pyrimidinyl-1H-indazol-4-amine	0,34	Lck	49,52	N-4-Pyrimidinyl-1H-indazol-4-amine	Lck	null	3932	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of Lck : indazoles as phenol isosteres with improved pharmacokinetics .
10775561	0	N-Acetyl-L-cysteine	0,19	interleukin-1beta	32,49	N-Acetyl-L-cysteine	interleukin-1beta	MESH:D000111	24494(Tax:10116)	Chemical	Gene	induction|amod|START_ENTITY induction|amod|END_ENTITY	N-Acetyl-L-cysteine potentiates interleukin-1beta induction of nitric_oxide synthase : role of p44/42 mitogen-activated protein kinases .
12660320	0	N-Acetyl-seryl-aspartyl-lysyl-proline	0,37	plasminogen_activator_inhibitor-1	65,98	N-Acetyl-seryl-aspartyl-lysyl-proline	plasminogen activator inhibitor-1	null	5054	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	N-Acetyl-seryl-aspartyl-lysyl-proline inhibits TGF-beta-mediated plasminogen_activator_inhibitor-1 expression via inhibition of Smad pathway in human mesangial cells .
25599738	0	N-Acetyl_Cysteine	10,27	Interleukin-18	82,96	N-Acetyl Cysteine	Interleukin-18	MESH:D000111	3606	Chemical	Gene	Effect|nmod|START_ENTITY Effect|amod|END_ENTITY	Effect of N-Acetyl_Cysteine and Vitamin_C on Kidney Allograft Function Biomarkers Interleukin-18 and Neutrophil_Gelatinase-associated_Lipocalin .
26392121	0	N-Acetylcysteine	0,16	tumor_necrosis_factor_alpha	28,55	N-Acetylcysteine	tumor necrosis factor alpha	MESH:D000111	7124	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|levels levels|compound|END_ENTITY	N-Acetylcysteine attenuates tumor_necrosis_factor_alpha levels in autoimmune inner_ear_disease patients .
26705137	0	N-Acylhydrazone	59,74	Histone_Deacetylase_6	97,118	N-Acylhydrazone	Histone Deacetylase 6	null	10013	Chemical	Gene	Derivatives|compound|START_ENTITY Derivatives|nmod|END_ENTITY	Design , Synthesis , and Pharmacological Evaluation of Novel N-Acylhydrazone Derivatives as Potent Histone_Deacetylase_6 / 8 Dual Inhibitors .
26306006	0	N-Acylhydrazone	63,78	IKK2	79,83	N-Acylhydrazone	IKK2	null	3551	Chemical	Gene	Inhibitor|compound|START_ENTITY Inhibitor|compound|END_ENTITY	LASSBio-1829_Hydrochloride : Development of a New Orally Active N-Acylhydrazone IKK2 Inhibitor with Anti-inflammatory Properties .
26306006	0	N-Acylhydrazone	63,78	IKK2	79,83	N-Acylhydrazone	IKK2	null	3551	Chemical	Gene	Inhibitor|compound|START_ENTITY Inhibitor|compound|END_ENTITY	LASSBio-1829_Hydrochloride : Development of a New Orally Active N-Acylhydrazone IKK2 Inhibitor with Anti-inflammatory Properties .
11277534	0	N-Aminoindoline	0,15	5-lipoxygenase	45,59	N-Aminoindoline	5-lipoxygenase	null	240	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	N-Aminoindoline derivatives as inhibitors of 5-lipoxygenase .
15125957	0	N-Aryl-gamma-lactams	0,20	integrin_alphavbeta3	24,44	N-Aryl-gamma-lactams	integrin alphavbeta3	null	3685	Chemical	Gene	START_ENTITY|nmod|antagonists antagonists|amod|END_ENTITY	N-Aryl-gamma-lactams as integrin_alphavbeta3 antagonists .
16930298	0	N-Benzoyl-D-phenylalanine	0,25	acetylcholinesterase	43,63	N-Benzoyl-D-phenylalanine	acetylcholinesterase	null	83817(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|END_ENTITY	N-Benzoyl-D-phenylalanine attenuates brain acetylcholinesterase in neonatal streptozotocin-diabetic rats .
22897946	0	N-Benzoyl_anthranilic_acid	0,26	AKR1C3	86,92	N-Benzoyl anthranilic acid	AKR1C3	CHEBI:50037	8644	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	N-Benzoyl_anthranilic_acid derivatives as selective inhibitors of aldo-keto reductase AKR1C3 .
8863489	0	N-CBZ-L-phenylalanyl-L-alanine-diazomethyl_ketone	165,214	cathepsin_D	32,43	N-CBZ-L-phenylalanyl-L-alanine-diazomethyl ketone	cathepsin D	null	1509	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|amod|END_ENTITY	Cytosolic proteolysis of tau by cathepsin_D in hippocampus following suppression of cathepsins B and L. Incubation of cultured hippocampal slices with an inhibitor -LSB- N-CBZ-L-phenylalanyl-L-alanine-diazomethyl_ketone -LRB- ZPAD -RRB- -RSB- of cathepsins B and L resulted in the degradation of high molecular weight isoforms of tau protein and the production of a 29-kDa tau fragment -LRB- tau 29 -RRB- .
12171932	0	N-Ethylmaleimide	0,16	Akt	71,74	N-Ethylmaleimide	Akt	MESH:D005033	207	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|phosphorylation phosphorylation|compound|END_ENTITY	N-Ethylmaleimide inhibits platelet-derived growth factor BB-stimulated Akt phosphorylation via activation of protein phosphatase_2A .
9986723	0	N-Methyl-5-tert-butyltryptamine	0,31	5-HT1D	56,62	N-Methyl-5-tert-butyltryptamine	5-HT1D	MESH:C117681	3352	Chemical	Gene	START_ENTITY|dep|agonist agonist|amod|END_ENTITY	N-Methyl-5-tert-butyltryptamine : A novel , highly potent 5-HT1D receptor agonist .
26321020	0	N-Methyl-D-Aspartate	94,114	CA1	90,93	N-Methyl-D-Aspartate	CA1	D016202	759	Chemical	Gene	Receptors|compound|START_ENTITY Receptors|compound|END_ENTITY	Temporal Memory and Its Enhancement by Estradiol Requires Surface Dynamics of Hippocampal CA1 N-Methyl-D-Aspartate Receptors .
26020650	0	N-Methyl-D-Aspartate	21,41	GRIN2B	63,69	N-Methyl-D-Aspartate	GRIN2B	D016202	2904	Chemical	Gene	Subunit|compound|START_ENTITY Subunit|appos|END_ENTITY	Association Study of N-Methyl-D-Aspartate Receptor Subunit 2B -LRB- GRIN2B -RRB- Polymorphisms and Schizophrenia Symptoms in the Han Chinese Population .
26020650	0	N-Methyl-D-Aspartate	21,41	GRIN2B	63,69	N-Methyl-D-Aspartate	GRIN2B	D016202	2904	Chemical	Gene	Subunit|compound|START_ENTITY Subunit|appos|END_ENTITY	Association Study of N-Methyl-D-Aspartate Receptor Subunit 2B -LRB- GRIN2B -RRB- Polymorphisms and Schizophrenia Symptoms in the Han Chinese Population .
26771436	0	N-Methyl-D-Aspartate	15,35	GRIN2B	57,63	N-Methyl-D-Aspartate	GRIN2B	D016202	2904	Chemical	Gene	Subunit|amod|START_ENTITY Association|nmod|Subunit Association|appos|END_ENTITY	Association of N-Methyl-D-Aspartate receptor 2B Subunit -LRB- GRIN2B -RRB- polymorphism with earlier age at onset of withdrawal symptoms in Indian alcohol dependent subjects .
26392130	0	N-Methyl-D-Aspartate	127,147	GluN2D	120,126	N-Methyl-D-Aspartate	GluN2D	D016202	2906	Chemical	Gene	Subunit|compound|START_ENTITY Subunit|compound|END_ENTITY	Alpha-Synuclein Produces Early Behavioral Alterations Via Striatal Cholinergic Synaptic Dysfunction by Interacting with GluN2D N-Methyl-D-Aspartate Receptor Subunit .
16402025	0	N-Methyl-D-Aspartic_acid	0,24	Akt	36,39	N-Methyl-D-Aspartic acid	Akt	CHEBI:31882	24185(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|activity activity|compound|END_ENTITY	N-Methyl-D-Aspartic_acid suppresses Akt activity through protein phosphatase in retinal ganglion cells .
11248442	0	N-Methyl-D-aspartate	19,39	CA1	93,96	N-Methyl-D-aspartate	CA1	CHEBI:31882	759	Chemical	Gene	expressions|amod|START_ENTITY alterations|nmod|expressions alterations|nmod|area area|compound|END_ENTITY	The alterations of N-Methyl-D-aspartate receptor expressions and oxidative DNA damage in the CA1 area at the early time after ischemia-reperfusion insult .
24327561	2	N-Methyl-D-aspartate	339,359	CA3	335,338	N-Methyl-D-aspartate	CA1	CHEBI:31882	759	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	We investigated the roles that prior experience and hippocampal CA3 N-Methyl-D-aspartate receptor -LRB- NMDAR -RRB- - dependent synaptic plasticity play in CA1 place cell sequence encoding and learning during novel spatial experiences .
10717408	0	N-Methyl-D-aspartate	0,20	NR1	30,33	N-Methyl-D-aspartate	NR1	CHEBI:31882	24408(Tax:10116)	Chemical	Gene	level|amod|START_ENTITY level|nummod|END_ENTITY	N-Methyl-D-aspartate receptor NR1 subunit mRNA level was decreased in rat brain during pentobarbital withdrawal .
17606616	0	N-Methyl-D-aspartate	0,20	NR1	45,48	N-Methyl-D-aspartate	NR1	CHEBI:31882	2902	Chemical	Gene	receptor|amod|START_ENTITY receptor|amod|subunit subunit|dep|END_ENTITY	N-Methyl-D-aspartate -LRB- NMDA -RRB- receptor subunit NR1 forms the substrate for oligomeric assembly of the NMDA receptor .
7624042	0	N-Methyl-D-aspartate	0,20	NR1	39,42	N-Methyl-D-aspartate	NR1	CHEBI:31882	14810(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY subunits|nsubj|receptor subunits|ccomp|overexpressed overexpressed|nsubjpass|END_ENTITY	N-Methyl-D-aspartate receptor subunits NR1 and NR2C are overexpressed in the inferior colliculus of audiogenic mice .
19487695	0	N-Methyl-D-aspartate	116,136	NR2A	100,104	N-Methyl-D-aspartate	NR2A	CHEBI:31882	2903	Chemical	Gene	receptors|amod|START_ENTITY subunit|nmod|receptors subunit|compound|END_ENTITY	An endoplasmic reticulum retention signal located in the extracellular amino-terminal domain of the NR2A subunit of N-Methyl-D-aspartate receptors .
23648631	0	N-Methyl-D-aspartate	22,42	NR2B	77,81	N-Methyl-D-aspartate	NR2B	CHEBI:31882	2904	Chemical	Gene	receptor|amod|START_ENTITY Identification|nmod|receptor Identification|dep|epitope epitope|appos|END_ENTITY	Identification of the N-Methyl-D-aspartate receptor -LRB- NMDAR -RRB- - related epitope , NR2B , in the normal human ovary : implication for the pathogenesis of anti-NMDAR encephalitis .
12716304	0	N-Methyl-N-Nitrosourea	98,120	p53	74,77	N-Methyl-N-Nitrosourea	p53	MESH:D008770	22060(Tax:10090)	Chemical	Gene	Given|dobj|START_ENTITY Given|nsubj|Lack Lack|nmod|Sensitivity Sensitivity|nmod|Stomach Stomach|nmod|Mice Mice|compound|END_ENTITY	Lack of Carcinogenic Sensitivity of the Glandular Stomach in Heterozygous p53 Knockout Mice Given N-Methyl-N-Nitrosourea in their Drinking Water for 26 Weeks .
18827072	0	N-Methyl-N-Nitrosourea	0,22	p53	62,65	N-Methyl-N-Nitrosourea	p53	MESH:D008770	22060(Tax:10090)	Chemical	Gene	START_ENTITY|dep|chemical chemical|nmod|/ /|compound|END_ENTITY	N-Methyl-N-Nitrosourea -LRB- MNU -RRB- : A positive control chemical for p53 + / - mouse carcinogenicity studies .
24878076	0	N-Methyl-d-aspartate	137,157	GluN2D	119,125	N-Methyl-d-aspartate	GluN2D	D016202	2906	Chemical	Gene	Receptors|compound|START_ENTITY Receptors|compound|END_ENTITY	Correction to Synthesis and Structure Activity Relationship of Tetrahydroisoquinoline-Based Potentiators of GluN2C and GluN2D Containing N-Methyl-d-aspartate Receptors .
22362014	5	N-Methyl-d-aspartate	617,637	NMDA	639,643	N-Methyl-d-aspartate	NR2B	CHEBI:31882	24410(Tax:10116)	Chemical	Gene	receptor_subunit_2A|amod|START_ENTITY receptor_subunit_2A|appos|END_ENTITY	N-Methyl-d-aspartate _ -LRB- NMDA -RRB- _ receptor_subunit_2A -LRB- NR2A -RRB- increased during gestation both in hippocampus and cerebral cortex compared to the control group ; in all treatment groups NR2B decreased in hippocampus and in cerebral cortex during the lactation period .
24627764	0	N-Methylamino_L-Alanine	43,66	SOD1	11,15	N-Methylamino L-Alanine	SOD1	null	39251(Tax:7227)	Chemical	Gene	enhances|dobj|START_ENTITY enhances|nsubj|END_ENTITY	ALS-linked SOD1 in glial cells enhances - N-Methylamino_L-Alanine -LRB- BMAA -RRB- - induced toxicity in Drosophila .
23978358	0	N-Methylanilide	0,15	phosphodiesterase_10A	53,74	N-Methylanilide	phosphodiesterase 10A	null	10846	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	N-Methylanilide and N-methylbenzamide derivatives as phosphodiesterase_10A -LRB- PDE10A -RRB- inhibitors .
9667974	0	N-Phenylamidines	0,16	nitric_oxide_synthase	59,80	N-Phenylamidines	nitric oxide synthase	null	4842	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	N-Phenylamidines as selective inhibitors of human neuronal nitric_oxide_synthase : structure-activity studies and demonstration of in vivo activity .
26037319	0	N-Substituted_pyrazole-3-carboxamides	0,37	15-lipoxygenase	61,76	N-Substituted pyrazole-3-carboxamides	15-lipoxygenase	null	246	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	N-Substituted_pyrazole-3-carboxamides as inhibitors of human 15-lipoxygenase .
10889259	0	N-acetyl	40,48	GntI	76,80	N-acetyl	GntI	null	829981(Tax:3702)	Chemical	Gene	cDNA|compound|START_ENTITY cDNA|appos|END_ENTITY	Isolation and characterization of plant N-acetyl glucosaminyltransferase_I -LRB- GntI -RRB- cDNA sequences .
214328	0	N-acetyl-L-aspartic_acid	33,57	NAAA	59,63	N-acetyl-L-aspartic acid	NAAA	CHEBI:21547	27163	Chemical	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	An electrophysiological study of N-acetyl-L-aspartic_acid -LRB- NAAA -RRB- on the stellate ganglion of the squid .
2355230	0	N-acetyl-L-aspartyl-beta-linked_L-glutamate	83,126	N-acetylated-alpha-linked_acidic_dipeptidase	26,70	N-acetyl-L-aspartyl-beta-linked L-glutamate	N-acetylated-alpha-linked acidic dipeptidase	null	85309(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|activity activity|amod|END_ENTITY	Competitive inhibition of N-acetylated-alpha-linked_acidic_dipeptidase activity by N-acetyl-L-aspartyl-beta-linked_L-glutamate .
26671656	0	N-acetyl-L-cysteine	0,19	MnSOD	30,35	N-acetyl-L-cysteine	MnSOD	MESH:D000111	6648	Chemical	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	N-acetyl-L-cysteine increases MnSOD activity and enhances the recruitment of quiescent human fibroblasts to the proliferation cycle during wound healing .
8001675	2	N-acetyl-L-cysteine	266,285	Syk	318,321	N-acetyl-L-cysteine	NAC	MESH:D000111	7504	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|compound|END_ENTITY	Here we show that the antioxidant drug N-acetyl-L-cysteine -LRB- NAC -RRB- inhibits antigen-mediated Syk activation whereas Lyn activation and phosphorylation of beta and gamma is maintained .
9210957	0	N-acetyl-L-cysteine	49,68	bcl-2	104,109	N-acetyl-L-cysteine	bcl-2	MESH:D000111	596	Chemical	Gene	START_ENTITY|nmod|modulation modulation|nmod|END_ENTITY	Suppression of nitric_oxide-induced apoptosis by N-acetyl-L-cysteine through modulation of glutathione , bcl-2 , and bax protein levels .
14766088	0	N-acetyl-L-cysteine	11,30	caspase-3	101,110	N-acetyl-L-cysteine	caspase-3	MESH:D000111	25402(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Effect of N-acetyl-L-cysteine and catalase on apoptosis of lens epithelial cell and the activity of caspase-3 -RSB- .
7926024	0	N-acetyl-L-cysteine	14,33	interleukin-6	37,50	N-acetyl-L-cysteine	interleukin-6	MESH:D000111	16193(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|induction induction|amod|END_ENTITY	Inhibition by N-acetyl-L-cysteine of interleukin-6 mRNA induction and activation of NF_kappa_B by tumor_necrosis_factor_alpha in a mouse fibroblastic cell line , Balb/3T3 .
7926024	0	N-acetyl-L-cysteine	14,33	tumor_necrosis_factor_alpha	98,125	N-acetyl-L-cysteine	tumor necrosis factor alpha	MESH:D000111	21926(Tax:10090)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition by N-acetyl-L-cysteine of interleukin-6 mRNA induction and activation of NF_kappa_B by tumor_necrosis_factor_alpha in a mouse fibroblastic cell line , Balb/3T3 .
3977320	0	N-acetyl-L-glutamate	38,58	growth_hormone	10,24	N-acetyl-L-glutamate	growth hormone	CHEBI:17533	81668(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of growth_hormone on rat liver N-acetyl-L-glutamate .
9523332	0	N-acetyl-L-tyrosine	0,19	tyrosinase	54,64	N-acetyl-L-tyrosine	tyrosinase	CHEBI:21563	7299	Chemical	Gene	START_ENTITY|nmod|substrate substrate|nmod|END_ENTITY	N-acetyl-L-tyrosine -LRB- NAT -RRB- as a substrate for mushroom tyrosinase .
20599927	0	N-acetyl-Proline-Glycine-Proline	31,63	CXCR1	116,121	N-acetyl-Proline-Glycine-Proline	CXCR1	MESH:C428643	3577	Chemical	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	The collagen-breakdown product N-acetyl-Proline-Glycine-Proline -LRB- N-alpha-PGP -RRB- does not interact directly with human CXCR1 and CXCR2 .
12154106	0	N-acetyl-Ser-Asp-Lys-Pro	0,24	Smad2	53,58	N-acetyl-Ser-Asp-Lys-Pro	Smad2	MESH:C058504	29357(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	N-acetyl-Ser-Asp-Lys-Pro inhibits phosphorylation of Smad2 in cardiac fibroblasts .
8258938	0	N-acetyl-beta	38,51	NAG_A	74,79	N-acetyl-beta	NAG A	null	4668	Chemical	Gene	A|amod|START_ENTITY A|appos|END_ENTITY	-LSB- Study on the enzymatic properties of N-acetyl-beta , D-glucosaminidase A -LRB- NAG_A -RRB- from the tissue of renal_cell_carcinomas : comparison of the enzymatic properties with those of normal renal tissues , with special regard to sugar-chain structures -RSB- .
21394639	0	N-acetyl-cysteine	10,27	erythropoietin	45,59	N-acetyl-cysteine	erythropoietin	MESH:D000111	2056	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|production production|compound|END_ENTITY	Effect of N-acetyl-cysteine and hyperoxia on erythropoietin production .
8387297	0	N-acetyl-p-aminobenzoquinone_imine	30,64	CYP3A4	74,80	N-acetyl-p-aminobenzoquinone imine	CYP3A4	null	1576	Chemical	Gene	Oxidation|nmod|START_ENTITY Oxidation|nmod|END_ENTITY	Oxidation of acetaminophen to N-acetyl-p-aminobenzoquinone_imine by human CYP3A4 .
10588226	3	N-acetyl-seryl-aspartyl-lysyl-proline	676,713	ACE	648,651	N-acetyl-seryl-aspartyl-lysyl-proline	AII	null	183	Chemical	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	In fact , there are several different ways of assessing ACE in vivo : these are serum ACE activity itself , plasma N-acetyl-seryl-aspartyl-lysyl-proline -LRB- AcSDKP -RRB- , urine AcSDKP , plasma angiotensin_I -LRB- AI -RRB- , plasma angiotensin_II -LRB- AII -RRB- , or the AII/AI ratio .
26908203	0	N-acetyl_cysteine	87,104	IL-8	13,17	N-acetyl cysteine	IL-8	MESH:D000111	3576	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of IL-8 -LRB- CXCL8 -RRB- and MCP-1 -LRB- CCL2 -RRB- with oxidative stress and its inhibition with N-acetyl_cysteine -LRB- NAC -RRB- in cell culture model using HK-2 cell .
23883583	0	N-acetyl_lysyltyrosylcysteine_amide	0,35	myeloperoxidase	45,60	N-acetyl lysyltyrosylcysteine amide	myeloperoxidase	null	4353	Chemical	Gene	inhibits|dep|START_ENTITY inhibits|nsubj|END_ENTITY	N-acetyl_lysyltyrosylcysteine_amide inhibits myeloperoxidase , a novel tripeptide inhibitor .
2695238	0	N-acetylalanine	159,174	aminopeptidase	175,189	N-acetylalanine	aminopeptidase	CHEBI:40992	10404	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Cell cycle phases of two human lung_tumor cell lines derived from squamous_cell_carcinoma and pulmonary_metastasis of a rhabdomyosarcoma -LRB- HS 24 and HS 57 -RRB- and N-acetylalanine aminopeptidase activity .
3528380	0	N-acetylalanine	0,15	aminopeptidase	16,30	N-acetylalanine	aminopeptidase	CHEBI:40992	10404	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	N-acetylalanine aminopeptidase activity in normal and tumour cells .
15453986	0	N-acetylaspartate	44,61	cyclosporin_A	25,38	N-acetylaspartate	cyclosporin A	null	1161	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The protective effect of cyclosporin_A upon N-acetylaspartate and mitochondrial_dysfunction following experimental diffuse_traumatic_brain_injury .
15836619	0	N-acetylaspartylglutamate	58,83	glutamate_carboxypeptidase_II	14,43	N-acetylaspartylglutamate	glutamate carboxypeptidase II	MESH:C027172	2346	Chemical	Gene	hydrolysis|nmod|START_ENTITY hydrolysis|amod|END_ENTITY	Regulation of glutamate_carboxypeptidase_II hydrolysis of N-acetylaspartylglutamate -LRB- NAAG -RRB- in crayfish nervous tissue is mediated by glial glutamate and acetylcholine receptors .
9622670	0	N-acetylaspartylglutamate	31,56	glutamate_carboxypeptidase_II	80,109	N-acetylaspartylglutamate	glutamate carboxypeptidase II	MESH:C027172	2346	Chemical	Gene	Hydrolysis|nmod|START_ENTITY Hydrolysis|nmod|END_ENTITY	Hydrolysis of the neuropeptide N-acetylaspartylglutamate -LRB- NAAG -RRB- by cloned human glutamate_carboxypeptidase_II .
24434384	0	N-acetylcysteine	29,45	C-reactive_protein	69,87	N-acetylcysteine	C-reactive protein	MESH:D000111	1401	Chemical	Gene	levels|amod|START_ENTITY levels|nmod|END_ENTITY	The effect of treatment with N-acetylcysteine on the serum levels of C-reactive_protein and interleukin-6 in patients on hemodialysis .
12682719	0	N-acetylcysteine	13,29	CRP	46,49	N-acetylcysteine	CRP	MESH:D000111	1401	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|END_ENTITY	Prophylactic N-acetylcysteine decreases serum CRP but not PCT levels and microalbuminuria following major abdominal surgery .
20113272	0	N-acetylcysteine	100,116	Cystatin_C	0,10	N-acetylcysteine	Cystatin C	MESH:D000111	1471	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|END_ENTITY	Cystatin_C and creatinine as markers for radiocontrast-induced_nephropathy in patients treated with N-acetylcysteine .
16983658	0	N-acetylcysteine	26,42	ERK	125,128	N-acetylcysteine	ERK	MESH:D000111	5594	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|involvement involvement|nmod|END_ENTITY	Neuroprotective effect of N-acetylcysteine on neuronal apoptosis induced by a synthetic gingerdione compound : involvement of ERK and p38 phosphorylation .
19426596	8	N-acetylcysteine	981,997	FL	1028,1030	N-acetylcysteine	FL	MESH:D000111	2323	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|production production|compound|END_ENTITY	The effect of N-acetylcysteine -LRB- a free radical scavenger -RRB- on FL production following the exposure to 5-Fu was examined .
24612076	0	N-acetylcysteine	37,53	GLT-1	22,27	N-acetylcysteine	GLT-1	MESH:D000111	29482(Tax:10116)	Chemical	Gene	inhibition|amod|START_ENTITY mediates|dobj|inhibition mediates|nsubj|END_ENTITY	Glutamate_transporter GLT-1 mediates N-acetylcysteine inhibition of cocaine reinstatement .
11544433	0	N-acetylcysteine	0,16	ICAM-1	92,98	N-acetylcysteine	ICAM-1	MESH:D000111	3383	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|increase increase|nmod|END_ENTITY	N-acetylcysteine attenuates the increase in alpha-glutathione_S-transferase and circulating ICAM-1 and VCAM-1 after reperfusion in humans undergoing liver transplantation .
17072061	0	N-acetylcysteine	13,29	ICAM-1	33,39	N-acetylcysteine	ICAM-1	MESH:D000111	3383	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Influence of N-acetylcysteine on ICAM-1 expression and IL-8 release from endothelial and epithelial cells .
17526765	0	N-acetylcysteine	114,130	ICAM-1	0,6	N-acetylcysteine	ICAM-1	MESH:D000111	3383	Chemical	Gene	effect|nmod|START_ENTITY expression|dep|effect expression|compound|END_ENTITY	ICAM-1 and CD11b/CD18 expression during acute pancreatitis induced by bile-pancreatic duct obstruction : effect of N-acetylcysteine .
12565201	0	N-acetylcysteine	110,126	IL-1beta	76,84	N-acetylcysteine	IL-1beta	MESH:D000111	3553	Chemical	Gene	effect|nmod|START_ENTITY effect|compound|END_ENTITY	Astroglial CYP1B1 up-regulation in inflammatory/oxidative toxic conditions : IL-1beta effect and protection by N-acetylcysteine .
18630691	0	N-acetylcysteine	11,27	IL-8	62,66	N-acetylcysteine	IL-8	MESH:D000111	3576	Chemical	Gene	Effect|nmod|START_ENTITY stimulating|nsubj|Effect stimulating|dobj|expression expression|compound|END_ENTITY	-LSB- Effect of N-acetylcysteine on lipopolysaccharide stimulating IL-8 expression of human uterine smooth cell -RSB- .
20360623	0	N-acetylcysteine	0,16	IL-8	26,30	N-acetylcysteine	IL-8	MESH:D000111	3576	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|compound|END_ENTITY	N-acetylcysteine inhibits IL-8 and MMP-9 release and ICAM-1 expression by bronchoalveolar cells from interstitial_lung_disease patients .
9692114	0	N-acetylcysteine	0,16	IL-8	45,49	N-acetylcysteine	IL-8	MESH:D000111	3576	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|amod|END_ENTITY	N-acetylcysteine inhibits IL-1_alpha-induced IL-8 secretion by bronchial epithelial cells .
17030433	0	N-acetylcysteine	12,28	JNK3	56,60	N-acetylcysteine	JNK3	MESH:D000111	25272(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	Antioxidant N-acetylcysteine inhibits the activation of JNK3 mediated by the GluR6-PSD95-MLK3 signaling module during cerebral_ischemia in rat hippocampus .
23765110	0	N-acetylcysteine	13,29	Klotho	33,39	N-acetylcysteine	Klotho	MESH:D000111	16591(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Influence of N-acetylcysteine on Klotho expression and its signaling pathway in experimental model of chronic cyclosporine nephropathy in mice .
19965809	0	N-acetylcysteine	0,16	RhoA	26,30	N-acetylcysteine	RhoA	MESH:D000111	11848(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	N-acetylcysteine inhibits RhoA and promotes apoptotic cell clearance during intense lung_inflammation .
22727548	0	N-acetylcysteine	0,16	TNF-a	35,40	N-acetylcysteine	TNF-a	MESH:D000111	21926(Tax:10090)	Chemical	Gene	treatment|amod|START_ENTITY reduces|nsubj|treatment reduces|dobj|levels levels|amod|END_ENTITY	N-acetylcysteine treatment reduces TNF-a levels and myonecrosis in diaphragm muscle of mdx mice .
27061477	0	N-acetylcysteine	14,30	TNF-a	56,61	N-acetylcysteine	TNF-a	MESH:D000111	7124	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of N-acetylcysteine and calcium_hydroxide on TNF-a and TGF-b1 in lipopolysaccharide-activated macrophages .
16952378	0	N-acetylcysteine	0,16	TNF-alpha	28,37	N-acetylcysteine	TNF-alpha	MESH:D000111	21926(Tax:10090)	Chemical	Gene	attenuates|amod|START_ENTITY END_ENTITY|nsubj|attenuates	N-acetylcysteine attenuates TNF-alpha induced changes in secretion of interleukin-6 , plasminogen_activator_inhibitor-1 and adiponectin from 3T3-L1 adipocytes .
20056085	0	N-acetylcysteine	1,17	TNF-alpha	71,80	N-acetylcysteine	TNF-alpha	MESH:D000111	21926(Tax:10090)	Chemical	Gene	antagonizes|nsubj|START_ENTITY antagonizes|dobj|expression expression|nmod|END_ENTITY	-LSB- N-acetylcysteine antagonizes the Interleukin-18-induced expression of TNF-alpha and IL-6 in mouse vascular smooth muscle cells -RSB- .
20560295	0	N-acetylcysteine	0,16	TNF-alpha	26,35	N-acetylcysteine	TNF-alpha	MESH:D000111	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	N-acetylcysteine inhibits TNF-alpha , sTNFR , and TGF-beta1 release by alveolar macrophages in idiopathic_pulmonary_fibrosis in vitro .
10805219	1	N-acetylcysteine	56,72	VEGF	87,91	N-acetylcysteine	VEGF	MESH:D000111	7422	Chemical	Gene	downregulates|amod|START_ENTITY END_ENTITY|nsubj|downregulates	N-acetylcysteine downregulates VEGF production in vitro .
21952821	0	N-acetylcysteine	22,38	VEGF	81,85	N-acetylcysteine	VEGF	MESH:D000111	83785(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of antioxidant N-acetylcysteine on diabetic_retinopathy and expression of VEGF and ICAM-1 from retinal blood vessels of diabetic rats .
9043100	0	N-acetylcysteine	80,96	c-fos	27,32	N-acetylcysteine	c-fos	MESH:D000111	2353	Chemical	Gene	Suppression|nmod|START_ENTITY Suppression|nmod|END_ENTITY	Suppression of UVB-induced c-fos and c-jun expression in human keratinocytes by N-acetylcysteine .
11079466	0	N-acetylcysteine	73,89	cyclooxygenase-2	14,30	N-acetylcysteine	cyclooxygenase-2	MESH:D000111	5743	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of cyclooxygenase-2 expression in human osteoblastic cells by N-acetylcysteine .
11997384	0	N-acetylcysteine	0,16	cyclooxygenase-2	84,100	N-acetylcysteine	cyclooxygenase-2	MESH:D000111	19225(Tax:10090)	Chemical	Gene	START_ENTITY|dep|lessen lessen|dobj|cytotoxicity cytotoxicity|acl:relcl|associated associated|nmod|up-regulation up-regulation|amod|END_ENTITY	N-acetylcysteine and celecoxib lessen cadmium cytotoxicity which is associated with cyclooxygenase-2 up-regulation in mouse neuronal cells .
18174269	0	N-acetylcysteine	116,132	cystatin_C	59,69	N-acetylcysteine	cystatin C	MESH:D000111	1471	Chemical	Gene	induced|nmod|START_ENTITY contrast|acl|induced preventing|dobj|contrast filtration|advcl|preventing filtration|nmod|END_ENTITY	Improved estimation of glomerular filtration rate by serum cystatin_C in preventing contrast induced nephropathy by N-acetylcysteine or zinc -- preliminary results .
21710343	0	N-acetylcysteine	10,26	cystatin_C	70,80	N-acetylcysteine	cystatin C	MESH:D000111	1471	Chemical	Gene	Impact|nmod|START_ENTITY defined|nsubj|Impact defined|nmod|END_ENTITY	Impact of N-acetylcysteine on contrast-induced_nephropathy defined by cystatin_C in patients with ST-elevation_myocardial_infarction undergoing primary angioplasty .
22212518	0	N-acetylcysteine	0,16	cystatin_C	72,82	N-acetylcysteine	cystatin C	MESH:D000111	1471	Chemical	Gene	assessed|nsubj|START_ENTITY assessed|nmod|END_ENTITY	N-acetylcysteine in preventing contrast-induced_nephropathy assessed by cystatin_C .
24365793	0	N-acetylcysteine	35,51	cystatin_C	123,133	N-acetylcysteine	cystatin C	MESH:D000111	1471	Chemical	Gene	high-dose|dobj|START_ENTITY high-dose|advcl|saline saline|xcomp|prevent prevent|dobj|contrast-induced_nephropathy contrast-induced_nephropathy|acl|assessed assessed|nmod|END_ENTITY	Does intravenous or oral high-dose N-acetylcysteine in addition to saline prevent contrast-induced_nephropathy assessed by cystatin_C ?
17023264	0	N-acetylcysteine	14,30	endothelin-1	74,86	N-acetylcysteine	endothelin-1	MESH:D000111	1906	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|upregulation upregulation|amod|END_ENTITY	Evidence that N-acetylcysteine inhibits TNF-alpha-induced cerebrovascular endothelin-1 upregulation via inhibition of mitogen - and stress-activated protein kinase .
10766859	0	N-acetylcysteine	20,36	epidermal_growth_factor_receptor	80,112	N-acetylcysteine	epidermal growth factor receptor	MESH:D000111	1956	Chemical	Gene	START_ENTITY|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Distinct effects of N-acetylcysteine and nitric_oxide on angiotensin_II-induced epidermal_growth_factor_receptor phosphorylation and intracellular Ca -LRB- 2 + -RRB- levels .
11162642	0	N-acetylcysteine	0,16	extracellular_signal-regulated_kinase	64,101	N-acetylcysteine	extracellular signal-regulated kinase	MESH:D000111	5594	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	N-acetylcysteine inhibits angiotensin_ii-mediated activation of extracellular_signal-regulated_kinase and epidermal_growth_factor_receptor .
14726217	0	N-acetylcysteine	14,30	iNOS	96,100	N-acetylcysteine	iNOS	MESH:D000111	24599(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inducible_nitric_oxide_synthase inducible_nitric_oxide_synthase|appos|END_ENTITY	The effect of N-acetylcysteine -LRB- NAC -RRB- on liver and renal tissue inducible_nitric_oxide_synthase -LRB- iNOS -RRB- and tissue lipid peroxidation in obstructive_jaundice stimulated by lipopolysaccharide -LRB- LPS -RRB- .
19010165	0	N-acetylcysteine	10,26	interleukin-4	77,90	N-acetylcysteine	interleukin-4	MESH:D000111	3565	Chemical	Gene	administration|amod|START_ENTITY Effect|nmod|administration Effect|nmod|END_ENTITY	Effect of N-acetylcysteine administration on intraoperative plasma levels of interleukin-4 and interleukin-10 in liver transplant recipients .
14734137	0	N-acetylcysteine	0,16	interleukin-8	49,62	N-acetylcysteine	interleukin-8	MESH:D000111	3576	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	N-acetylcysteine inhibits interleukin-17-induced interleukin-8 production from human airway smooth muscle cells : a possible role for anti-oxidative treatment in chronic lung rejection ?
22766540	0	N-acetylcysteine	11,27	matrix_metalloproteinase-9	31,57	N-acetylcysteine	matrix metalloproteinase-9	MESH:D000111	4318	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|amod|END_ENTITY	Effects of N-acetylcysteine on matrix_metalloproteinase-9 secretion and cell migration of human corneal epithelial cells .
10736124	0	N-acetylcysteine	23,39	methemoglobin	50,63	N-acetylcysteine	methemoglobin	MESH:D000111	3048	Chemical	Gene	START_ENTITY|acl|reduce reduce|dobj|END_ENTITY	Failure of intravenous N-acetylcysteine to reduce methemoglobin produced by sodium_nitrite in human volunteers : A randomized controlled trial .
8909270	0	N-acetylcysteine	0,16	methemoglobin	25,38	N-acetylcysteine	methemoglobin	MESH:D000111	3048	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	N-acetylcysteine reduces methemoglobin in vitro .
9523930	0	N-acetylcysteine	0,16	methemoglobin	25,38	N-acetylcysteine	methemoglobin	MESH:D000111	3048	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	N-acetylcysteine reduces methemoglobin in an in-vitro model of glucose-6-phosphate_dehydrogenase deficiency .
20061637	0	N-acetylcysteine	0,16	neprilysin	102,112	N-acetylcysteine	neprilysin	MESH:D000111	4311	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|nmod|END_ENTITY	N-acetylcysteine prevents 4-hydroxynonenal - and amyloid-beta-induced modification and inactivation of neprilysin in SH-SY5Y cells .
24037197	0	N-acetylcysteine	63,79	peroxisome_proliferator-activated_receptor_gamma	81,129	N-acetylcysteine	peroxisome proliferator-activated receptor gamma	MESH:D000111	19016(Tax:10090)	Chemical	Gene	agonists|amod|START_ENTITY agonists|amod|END_ENTITY	Inhibition of rotavirus ECwt infection in ICR suckling mice by N-acetylcysteine , peroxisome_proliferator-activated_receptor_gamma agonists and cyclooxygenase-2 inhibitors .
8001980	0	N-acetylgalactosamine	66,87	GALNS	101,106	N-acetylgalactosamine	GALNS	CHEBI:28800	2588	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Morquio_A_syndrome : cloning , sequence , and structure of the human N-acetylgalactosamine 6-sulfatase -LRB- GALNS -RRB- gene .
24131475	0	N-acetylgalactosamine	0,21	IgA1	40,44	N-acetylgalactosamine	IgA1	CHEBI:28800	3493	Chemical	Gene	exposure|amod|START_ENTITY exposure|nmod|END_ENTITY	N-acetylgalactosamine exposure of serum IgA1 was associated with glomerulosclerosis and tubular_atrophy / interstitial fibrosis of IgA_nephropathy patients .
22722940	0	N-acetylgalactosamine	29,50	b4GalNAc-T3	142,153	N-acetylgalactosamine	b4GalNAc-T3	CHEBI:28800	283358	Chemical	Gene	transfer|nmod|START_ENTITY transfer|nmod|END_ENTITY	Peptide-specific transfer of N-acetylgalactosamine to O-linked glycans by the glycosyltransferases b1,4-N-acetylgalactosaminyl transferase 3 -LRB- b4GalNAc-T3 -RRB- and b4GalNAc-T4 .
10201849	0	N-acetylgalactosamine	47,68	beta-galactosidase	76,94	N-acetylgalactosamine	beta-galactosidase	CHEBI:28800	2720	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Synthesis of alpha-C -LRB- 1 -- > 3 -RRB- - mannopyranoside of N-acetylgalactosamine , a new beta-galactosidase inhibitor .
19478079	0	N-acetylglucosamine	9,28	CCAAT_enhancer-binding_protein_beta	45,80	N-acetylglucosamine	CCAAT enhancer-binding protein beta	CHEBI:28009	1051	Chemical	Gene	modification|amod|START_ENTITY modification|nmod|END_ENTITY	O-linked N-acetylglucosamine modification on CCAAT_enhancer-binding_protein_beta : role during adipocyte differentiation .
18767802	0	N-acetylglucosamine	50,69	O-4	91,94	N-acetylglucosamine	O-4	CHEBI:28009	28894	Chemical	Gene	protection|nmod|START_ENTITY protection|nmod|END_ENTITY	Convenient temporary methyl_imidate protection of N-acetylglucosamine and glycosylation at O-4 .
11371615	0	N-acetylglucosamine	13,32	Sp1	36,39	N-acetylglucosamine	Sp1	CHEBI:28009	6667	Chemical	Gene	START_ENTITY|nmod|domain domain|amod|END_ENTITY	O-linkage of N-acetylglucosamine to Sp1 activation domain inhibits its transcriptional capability .
21795679	0	N-acetylglucosamine	115,134	YY1	173,176	N-acetylglucosamine	YY1	CHEBI:28009	7528	Chemical	Gene	modification|amod|START_ENTITY modification|nmod|END_ENTITY	Cellular content of UDP-N-acetylhexosamines controls hyaluronan_synthase_2 expression and correlates with O-linked N-acetylglucosamine modification of transcription factors YY1 and SP1 .
11087713	0	N-acetylglucosamine	70,89	annexin_V	41,50	N-acetylglucosamine	annexin V	CHEBI:28009	308	Chemical	Gene	activity|nmod|START_ENTITY activity|nmod|END_ENTITY	A novel carbohydrate binding activity of annexin_V toward a bisecting N-acetylglucosamine .
14579566	0	N-acetylglucosamine	62,81	annexin_V	33,42	N-acetylglucosamine	annexin V	CHEBI:28009	308	Chemical	Gene	activity|nmod|START_ENTITY activity|nmod|END_ENTITY	Carbohydrate binding activity of annexin_V toward a bisecting N-acetylglucosamine .
19671924	0	N-acetylglucosamine	9,28	insulin_receptor_substrate-1	45,73	N-acetylglucosamine	insulin receptor substrate-1	CHEBI:28009	3667	Chemical	Gene	modification|amod|START_ENTITY modification|nmod|END_ENTITY	O-linked N-acetylglucosamine modification of insulin_receptor_substrate-1 occurs in close proximity to multiple SH2 domain binding motifs .
8370641	0	N-acetylimidazole	46,63	prolactin	31,40	N-acetylimidazole	prolactin	MESH:C012160	5617	Chemical	Gene	modification|nmod|START_ENTITY modification|nmod|END_ENTITY	Chemical modification of ovine prolactin with N-acetylimidazole .
2910347	0	N-acetylneuraminic_acid	4,27	transferrin	59,70	N-acetylneuraminic acid	transferrin	MESH:D019158	7018	Chemical	Gene	content|amod|START_ENTITY content|nmod|END_ENTITY	The N-acetylneuraminic_acid content of five forms of human transferrin .
10591054	0	N-acetylserotonin	73,90	MAO-A	47,52	N-acetylserotonin	MAO-A	MESH:C006389	29253(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY effects|dep|role effects|nmod|inhibition inhibition|amod|END_ENTITY	Antidepressive and antihypertensive effects of MAO-A inhibition : role of N-acetylserotonin .
9503569	0	N-acetylserotonin	1,18	MAO-A	45,50	N-acetylserotonin	MAO-A	MESH:C006389	29253(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	-LSB- N-acetylserotonin and hypotensive effect of MAO-A inhibitors -RSB- .
9564635	0	N-acetylserotonin	65,82	MAO-A	14,19	N-acetylserotonin	MAO-A	MESH:C006389	29253(Tax:10116)	Chemical	Gene	stress|nmod|START_ENTITY stress|nsubj|effect effect|nmod|inhibition inhibition|amod|END_ENTITY	The effect of MAO-A inhibition and cold-immobilization stress on N-acetylserotonin and melatonin in SHR and WKY rats .
20206142	0	N-acyl-dopamines	11,27	COX-2	35,40	N-acyl-dopamines	COX-2	null	4513	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|compound|END_ENTITY	Endogenous N-acyl-dopamines induce COX-2 expression in brain endothelial cells by stabilizing mRNA through a p38 dependent pathway .
26567045	0	N-acylethanolamines	29,48	TRPV1	104,109	N-acylethanolamines	TRPV1	MESH:C022203	193034(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY mediated|nsubjpass|effects mediated|nmod|END_ENTITY	Anti-inflammatory effects of N-acylethanolamines in rheumatoid_arthritis synovial cells are mediated by TRPV1 and TRPA1 in a COX-2 dependent manner .
12562826	0	N-acylethanolamines	83,102	phospholipase_A2	24,40	N-acylethanolamines	phospholipase A2	MESH:C022203	151056	Chemical	Gene	modulation|nmod|START_ENTITY modulation|nmod|activity activity|amod|END_ENTITY	Different modulation of phospholipase_A2 activity by saturated and monounsaturated N-acylethanolamines .
19880322	0	N-acylpolyamine	0,15	HDM2	30,34	N-acylpolyamine	HDM2	null	4193	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	N-acylpolyamine inhibitors of HDM2 and HDMX binding to p53 .
18586492	0	N-alkyl_glycine_amides	13,35	leukotriene_A4_hydrolase	60,84	N-alkyl glycine amides	leukotriene A4 hydrolase	null	4048	Chemical	Gene	Synthesis|nmod|START_ENTITY Synthesis|nmod|END_ENTITY	Synthesis of N-alkyl_glycine_amides as potent inhibitors of leukotriene_A4_hydrolase .
9873563	0	N-alkylated_saccharins	24,46	alpha-1a_adrenergic_receptor	60,88	N-alkylated saccharins	alpha-1a adrenergic receptor	null	146	Chemical	Gene	Design|nmod|START_ENTITY Design|nmod|antagonists antagonists|amod|END_ENTITY	Design and synthesis of N-alkylated_saccharins as selective alpha-1a_adrenergic_receptor antagonists .
2990543	0	N-alkylhydroxylamines	40,61	lipoxygenase_1	22,36	N-alkylhydroxylamines	lipoxygenase 1	null	547923(Tax:3847)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of soybean lipoxygenase_1 by N-alkylhydroxylamines .
20997	0	N-alpha-arylsulfonyl-L-arginine_methyl_esters	61,106	thrombin	15,23	N-alpha-arylsulfonyl-L-arginine methyl esters	thrombin	null	2147	Chemical	Gene	hydrolysis|nmod|START_ENTITY hydrolysis|amod|END_ENTITY	-LSB- Dependence of thrombin - and trypsin-catalyzed hydrolysis of N-alpha-arylsulfonyl-L-arginine_methyl_esters on the structure of acylamide part of substrates -RSB- .
4034633	0	N-alpha-benzyloxycarbonyl-4-amidinophenylalanine_amides	14,69	thrombin	73,81	N-alpha-benzyloxycarbonyl-4-amidinophenylalanine amides	thrombin	null	2147	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	-LSB- Synthesis of N-alpha-benzyloxycarbonyl-4-amidinophenylalanine_amides as thrombin inhibitors -RSB- .
15245490	0	N-arachidonoyl-dopamine	79,102	TRPV1	0,5	N-arachidonoyl-dopamine	TRPV1	MESH:C474941	83810(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|dep|effects	TRPV1 and CB -LRB- 1 -RRB- receptor-mediated effects of the endovanilloid/endocannabinoid N-arachidonoyl-dopamine on primary afferent fibre and spinal cord neuronal responses in the rat .
17984664	0	N-arachidonoyl-dopamine	32,55	TRPV1	93,98	N-arachidonoyl-dopamine	TRPV1	MESH:C474941	83810(Tax:10116)	Chemical	Gene	response|nmod|START_ENTITY response|dep|role role|nmod|receptor receptor|compound|END_ENTITY	Increased depressor response to N-arachidonoyl-dopamine during high salt intake : role of the TRPV1 receptor .
19619644	0	N-arachidonoyl-dopamine	109,132	TRPV1	17,22	N-arachidonoyl-dopamine	TRPV1	MESH:C474941	7442	Chemical	Gene	increases|nmod|START_ENTITY increases|nsubj|Up-regulation Up-regulation|nmod|END_ENTITY	Up-regulation of TRPV1 in mononuclear cells of end-stage_kidney_disease patients increases susceptibility to N-arachidonoyl-dopamine -LRB- NADA -RRB- - induced cell death .
18616956	0	N-arachidonoyl-serotonin	24,48	FAAH	52,56	N-arachidonoyl-serotonin	FAAH	null	29347(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	The analgesic effect of N-arachidonoyl-serotonin , a FAAH inhibitor and TRPV1 receptor antagonist , associated with changes in rostral ventromedial medulla and locus coeruleus cell activity in rats .
8474011	0	N-aralkyl	0,9	cytochrome_P450	121,136	N-aralkyl	cytochrome P450	null	100328948(Tax:9986)	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	N-aralkyl derivatives of 1-aminobenzotriazole as potent isozyme-selective mechanism-based inhibitors of rabbit pulmonary cytochrome_P450 in vivo .
22030028	0	N-aryl-2-acylindole	13,32	glucagon_receptor	39,56	N-aryl-2-acylindole	glucagon receptor	null	2642	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|compound|END_ENTITY	Discovery of N-aryl-2-acylindole human glucagon_receptor antagonists .
20933419	0	N-aryl_maleimides	25,42	Bfl-1	14,19	N-aryl maleimides	Bfl-1	null	597	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of Bfl-1 with N-aryl_maleimides .
25935642	0	N-aryl_piperazine	19,36	CXCR4	37,42	N-aryl piperazine	CXCR4	CHEBI:46848	7852	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|compound|END_ENTITY	Discovery of novel N-aryl_piperazine CXCR4 antagonists .
23497227	0	N-aryl_pyrido-quinazolines	37,63	epidermal_growth_factor_receptor	86,118	N-aryl pyrido-quinazolines	epidermal growth factor receptor	null	1956	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	Synthesis and in vitro evaluation of N-aryl_pyrido-quinazolines derivatives as potent epidermal_growth_factor_receptor inhibitors .
11675029	0	N-arylglycosylamines	52,72	trehalase	28,37	N-arylglycosylamines	trehalase	null	11181	Chemical	Gene	inhibitors|nmod|START_ENTITY inhibitors|amod|END_ENTITY	Syntheses and activities as trehalase inhibitors of N-arylglycosylamines derived from fluorinated anilines .
11515569	0	N-arylrolipram	49,63	PDE4	93,97	N-arylrolipram	PDE4	null	5141	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|inhibitors inhibitors|nmod|END_ENTITY	Synthesis and structure-activity relationship of N-arylrolipram derivatives as inhibitors of PDE4 isozymes .
9873708	0	N-arylrolipram	0,14	PDE4	51,55	N-arylrolipram	PDE4	null	5141	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	N-arylrolipram derivatives as potent and selective PDE4 inhibitors .
16267027	0	N-benzyladriamycin-14-valerate	0,30	phospholipid_scramblase_3	115,140	N-benzyladriamycin-14-valerate	phospholipid scramblase 3	MESH:C046808	57048	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	N-benzyladriamycin-14-valerate -LRB- AD198 -RRB- induces apoptosis through protein_kinase_C-delta-induced phosphorylation of phospholipid_scramblase_3 .
16302804	0	N-benzylisatin_sulfonamide	0,26	caspase-3	47,56	N-benzylisatin sulfonamide	caspase-3	null	836	Chemical	Gene	analogues|amod|START_ENTITY analogues|nmod|inhibitors inhibitors|amod|END_ENTITY	N-benzylisatin_sulfonamide analogues as potent caspase-3 inhibitors : synthesis , in vitro activity , and molecular modeling studies .
15878628	0	N-benzyloxycarbonyl-L-proline	0,29	prolidase	68,77	N-benzyloxycarbonyl-L-proline	prolidase	null	5184	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	N-benzyloxycarbonyl-L-proline : an in vitro and in vivo inhibitor of prolidase .
10425601	0	N-benzylpiperidine	24,42	acetylcholinesterase	64,84	N-benzylpiperidine	acetylcholinesterase	MESH:C071293	11423(Tax:10090)	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Automated docking of 82 N-benzylpiperidine derivatives to mouse acetylcholinesterase and comparative molecular field analysis with ` natural ' alignment .
1915081	0	N-bromoacetyl-L-thyroxine	22,47	protein_disulfide_isomerase	90,117	N-bromoacetyl-L-thyroxine	protein disulfide isomerase	MESH:C015042	25506(Tax:10116)	Chemical	Gene	protein|amod|START_ENTITY protein|nmod|END_ENTITY	Characterization of a N-bromoacetyl-L-thyroxine affinity-labeled 55-kilodalton protein as protein_disulfide_isomerase in cultured glial cells .
8243653	0	N-bromoacetyl-triiodothyronine	74,104	type_III_iodothyronine_deiodinase	16,49	N-bromoacetyl-triiodothyronine	type III iodothyronine deiodinase	null	29475(Tax:10116)	Chemical	Gene	Reaction|nmod|START_ENTITY Reaction|nmod|END_ENTITY	Reaction of the type_III_iodothyronine_deiodinase with the affinity label N-bromoacetyl-triiodothyronine .
809437	0	N-bromosuccinimide	46,64	alpha-lactalbumin	23,40	N-bromosuccinimide	alpha-lactalbumin	MESH:D001974	281894(Tax:9913)	Chemical	Gene	Modification|nmod|START_ENTITY Modification|nmod|END_ENTITY	Modification of bovine alpha-lactalbumin with N-bromosuccinimide and 2-hydroxy-5-nitrobenzylbromide .
917268	0	N-butyl_gallate	46,61	catechol-O-methyltransferase	14,42	N-butyl gallate	catechol-O-methyltransferase	MESH:C015048	1312	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of catechol-O-methyltransferase by N-butyl_gallate .
1168484	0	N-butyrylimidazole	37,55	thrombin	23,31	N-butyrylimidazole	thrombin	null	280685(Tax:9913)	Chemical	Gene	reaction|nmod|START_ENTITY reaction|nmod|END_ENTITY	The reaction of bovine thrombin with N-butyrylimidazole .
24485674	0	N-carbamoylglutamate	18,38	milk	42,46	N-carbamoylglutamate	milk	null	100532204	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|production production|compound|END_ENTITY	Effect of dietary N-carbamoylglutamate on milk production and nitrogen utilization in high-yielding dairy cows .
22404301	0	N-carbonylpyrrolidine	27,48	deoxyuridine_triphosphatase	121,148	N-carbonylpyrrolidine	deoxyuridine triphosphatase	null	1854	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Synthesis and discovery of N-carbonylpyrrolidine - or N-sulfonylpyrrolidine-containing uracil derivatives as potent human deoxyuridine_triphosphatase inhibitors .
6347175	0	N-carboxy-3-morpholino-sydnonimine-ethylester	66,111	renin	123,128	N-carboxy-3-morpholino-sydnonimine-ethylester	renin	null	403838(Tax:9615)	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	The effect of repeated intravenous and oral doses of molsidomine -LRB- N-carboxy-3-morpholino-sydnonimine-ethylester -RRB- on plasma renin activity and plasma catecholamine levels in conscious dogs .
2162675	0	N-carboxymethyldipeptides	67,92	angiotensin_converting_enzyme	14,43	N-carboxymethyldipeptides	angiotensin converting enzyme	null	1636	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Synthesis and angiotensin_converting_enzyme inhibitory activity of N-carboxymethyldipeptides with omega - -LRB- 4-piperidyl -RRB- alkyl group .
14510994	0	N-chlorotaurine	29,44	chloramine_T	64,76	N-chlorotaurine	chloramine T	MESH:C043410	847	Chemical	Gene	START_ENTITY|nmod|comparison comparison|nmod|END_ENTITY	Tolerability and efficacy of N-chlorotaurine in comparison with chloramine_T for the treatment of chronic_leg_ulcers with a purulent coating : a randomized phase II study .
11489433	0	N-desisopropylpropranolol	115,140	monoamine_oxidase	53,70	N-desisopropylpropranolol	monoamine oxidase	MESH:C012878	29253(Tax:10116)	Chemical	Gene	metabolism|nmod|START_ENTITY involvement|nmod|metabolism involvement|nmod|END_ENTITY	Side-chain metabolism of propranolol : involvement of monoamine_oxidase and aldehyde_reductase in the metabolism of N-desisopropylpropranolol to propranolol_glycol in rat liver .
17230619	0	N-desulfated_heparin	28,48	vascular_endothelial_growth_factor	66,100	N-desulfated heparin	vascular endothelial growth factor	MESH:C044153	7422	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of non-anticoagulant N-desulfated_heparin on expression of vascular_endothelial_growth_factor , angiogenesis and metastasis of orthotopic implantation of human gastric_carcinoma .
9704198	0	N-dicyclopropylmethyl-amino-2-oxazoline	10,49	S-3341	51,57	N-dicyclopropylmethyl-amino-2-oxazoline	S-3341	null	1079580(Tax:198215)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of N-dicyclopropylmethyl-amino-2-oxazoline -LRB- S-3341 -RRB- on antioxidant status and nitric_oxide in hypertensive patients .
10188593	0	N-ethyl_maleimide	23,40	delta6-desaturase	44,61	N-ethyl maleimide	delta6-desaturase	MESH:D005033	9415	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|amod|END_ENTITY	Differential effect of N-ethyl_maleimide on delta6-desaturase activity in human fetal liver toward fatty_acids of the n-6 and n-3 series .
2144286	0	N-ethylmaleimide	76,92	ATPase	58,64	N-ethylmaleimide	ATPase	MESH:D005033	1769	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	A structural change in the Neurospora plasma membrane -LSB- H + -RSB- ATPase induced by N-ethylmaleimide .
2991153	0	N-ethylmaleimide	65,81	Beta-endorphin	0,14	N-ethylmaleimide	Beta-endorphin	MESH:D005033	5443	Chemical	Gene	protect|nmod|START_ENTITY protect|nsubj|END_ENTITY	Beta-endorphin does not protect alkylation of opiate receptor by N-ethylmaleimide .
6244551	0	N-ethylmaleimide	93,109	enkephalin	39,49	N-ethylmaleimide	enkephalin	MESH:D005033	29237(Tax:10116)	Chemical	Gene	inactivation|nmod|START_ENTITY END_ENTITY|nmod|inactivation	Selective protection of stereospecific enkephalin and opiate binding against inactivation by N-ethylmaleimide : evidence for two classes of opiate receptors .
2947624	0	N-ethylmaleimide	37,53	myosin	106,112	N-ethylmaleimide	myosin	MESH:D005033	79784	Chemical	Gene	reaction|nmod|START_ENTITY sites|nmod|reaction Location|nmod|sites Location|nmod|chain chain|compound|END_ENTITY	Location of the sites of reaction of N-ethylmaleimide in papain and chymotryptic fragments of the gizzard myosin heavy chain .
2959657	0	N-ethylmaleimide	10,26	myosin	56,62	N-ethylmaleimide	myosin	MESH:D005033	79784	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of N-ethylmaleimide on Ca-inhibition of Physarum myosin .
6117553	2	N-ethylmaleimide	148,164	myosin	134,140	N-ethylmaleimide	myosin	MESH:D005033	79784	Chemical	Gene	modification|nmod|START_ENTITY modification|nmod|B B|compound|END_ENTITY	A chemical modification of colonic smooth myosin B with N-ethylmaleimide .
3040428	0	N-ethylmaleimide	0,16	substance_P_receptor	104,124	N-ethylmaleimide	substance P receptor	MESH:D005033	24807(Tax:10116)	Chemical	Gene	blocks|nsubj|START_ENTITY blocks|nmod|END_ENTITY	N-ethylmaleimide blocks the modulatory effects of divalent cations and guanine_nucleotides on the brain substance_P_receptor .
6573156	0	N-formimidoyl_thienamycin	34,59	MK0787	61,67	N-formimidoyl thienamycin	MK0787	MESH:D015378	1476888(Tax:190192)	Chemical	Gene	Pharmacokinetics|nmod|START_ENTITY Pharmacokinetics|appos|END_ENTITY	Pharmacokinetics and tolerance of N-formimidoyl_thienamycin -LRB- MK0787 -RRB- in humans .
6573157	0	N-formimidoyl_thienamycin	20,45	MK0787	47,53	N-formimidoyl thienamycin	MK0787	MESH:D015378	1476888(Tax:190192)	Chemical	Gene	recovery|nmod|START_ENTITY recovery|appos|END_ENTITY	Urinary recovery of N-formimidoyl_thienamycin -LRB- MK0787 -RRB- as affected by coadministration of N-formimidoyl_thienamycin dehydropeptidase inhibitors .
6573157	0	N-formimidoyl_thienamycin	90,115	MK0787	47,53	N-formimidoyl thienamycin	MK0787	MESH:D015378	1476888(Tax:190192)	Chemical	Gene	inhibitors|amod|START_ENTITY coadministration|nmod|inhibitors affected|nmod|coadministration recovery|acl|affected recovery|appos|END_ENTITY	Urinary recovery of N-formimidoyl_thienamycin -LRB- MK0787 -RRB- as affected by coadministration of N-formimidoyl_thienamycin dehydropeptidase inhibitors .
6818899	0	N-formimidoyl_thienamycin	23,48	MK0787	50,56	N-formimidoyl thienamycin	MK0787	MESH:D015378	1476888(Tax:190192)	Chemical	Gene	evaluation|nmod|START_ENTITY evaluation|appos|END_ENTITY	In vitro evaluation of N-formimidoyl_thienamycin -LRB- MK0787 -RRB- combined with amikacin against gram-negative bacilli and Staphylococcus_aureus .
6969580	0	N-formimidoyl_thienamycin	10,35	MK0787	37,43	N-formimidoyl thienamycin	MK0787	MESH:D015378	1476888(Tax:190192)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of N-formimidoyl_thienamycin -LRB- MK0787 -RRB- on beta-lactamases and activity against beta-lactamase-producing strains .
1464735	0	N-formyl-1-methionyl-1-leucyl-1-phenylalanine	63,108	Tumor_necrosis_factor-alpha	0,27	N-formyl-1-methionyl-1-leucyl-1-phenylalanine	Tumor necrosis factor-alpha	null	7124	Chemical	Gene	decreases|nmod|START_ENTITY decreases|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha decreases neutrophil chemotaxis to N-formyl-1-methionyl-1-leucyl-1-phenylalanine : analysis of single cell movement .
11238229	0	N-formyl-methionyl-leucyl-phenylalanine	0,39	FcgammaRI	113,122	N-formyl-methionyl-leucyl-phenylalanine	FcgammaRI	MESH:D009240	2209	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	N-formyl-methionyl-leucyl-phenylalanine inhibits both gamma interferon - and interleukin-10-induced expression of FcgammaRI on human monocytes .
17339487	0	N-formyl-methionyl-leucyl-phenylalanine	68,107	Hck	23,26	N-formyl-methionyl-leucyl-phenylalanine	Hck	MESH:D009240	3055	Chemical	Gene	regulate|nmod|START_ENTITY regulate|nsubj|END_ENTITY	The Src family kinases Hck and Fgr regulate neutrophil responses to N-formyl-methionyl-leucyl-phenylalanine .
8818543	0	N-formyl-methionyl-leucyl-phenylalanine	0,39	IL-1	62,66	N-formyl-methionyl-leucyl-phenylalanine	IL-1	MESH:D009240	3553	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	N-formyl-methionyl-leucyl-phenylalanine induces and modulates IL-1 and IL-6 in human PBMC .
17389234	3	N-formyl-methionyl-leucyl-phenylalanine	631,670	fMLP	672,676	N-formyl-methionyl-leucyl-phenylalanine	fMLP	MESH:D009240	2357	Chemical	Gene	-RSB-|amod|START_ENTITY -RSB-|compound|END_ENTITY	We also disclose that motility of hPMs and J774 .1 induced by a chemotactic peptide -LRB- N-formyl-methionyl-leucyl-phenylalanine -LSB- fMLP -RSB- -RRB- was inhibited by superoxide dismutase or N-acetylcystein , indicating stimulation of motility by superoxide generated by fMLP stimulation .
7626126	0	N-formyl-methionyl-leucyl-phenylalanine	76,115	p72syk	66,72	N-formyl-methionyl-leucyl-phenylalanine	p72syk	MESH:D009240	6850	Chemical	Gene	receptor|amod|START_ENTITY END_ENTITY|nmod|receptor	Cyclic_AMP-elevating agents negatively regulate the activation of p72syk in N-formyl-methionyl-leucyl-phenylalanine receptor signaling .
8383965	0	N-formylmethionyl-leucyl-phenylalanine	23,61	microtubule-associated_protein_2	72,104	N-formylmethionyl-leucyl-phenylalanine	microtubule-associated protein 2	MESH:D009240	4133	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|kinase kinase|amod|END_ENTITY	The chemotactic factor N-formylmethionyl-leucyl-phenylalanine activates microtubule-associated_protein_2 -LRB- MAP -RRB- kinase and a MAP kinase kinase in polymorphonuclear leucocytes .
1417792	0	N-formylmethionyl-leucylphenylalanine	47,84	phospholipase_D	17,32	N-formylmethionyl-leucylphenylalanine	phospholipase D	MESH:D009240	2822	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Human neutrophil phospholipase_D activation by N-formylmethionyl-leucylphenylalanine reveals a two-step process for the control of phosphatidylcholine breakdown and oxidative burst .
2868456	0	N-formylmethionylleucylphenylalanine	47,83	FMLP	85,89	N-formylmethionylleucylphenylalanine	FMLP	MESH:D009240	2357	Chemical	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Countergradients of nonchemotactic ligands for N-formylmethionylleucylphenylalanine -LRB- FMLP -RRB- receptors promote FMLP-induced chemotaxis .
12595898	0	N-formylpeptide	30,45	FPR1	56,60	N-formylpeptide	FPR1	null	2357	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Evaluation of human leukocyte N-formylpeptide receptor -LRB- FPR1 -RRB- SNPs in aggressive_periodontitis patients .
2167012	0	N-glycosidic_carbohydrates	15,41	THP-1	96,101	N-glycosidic carbohydrates	THP-1	null	2736	Chemical	Gene	Recognition|nmod|START_ENTITY Recognition|nmod|END_ENTITY	Recognition of N-glycosidic_carbohydrates on esophageal_carcinoma cells by macrophage cell line THP-1 .
24524917	0	N-heterocyclic_carbene	70,92	thioredoxin_reductase	29,50	N-heterocyclic carbene	thioredoxin reductase	CHEBI:51369	25824	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Insights on the mechanism of thioredoxin_reductase inhibition by gold N-heterocyclic_carbene compounds using the synthetic linear selenocysteine containing C-terminal peptide hTrxR -LRB- 488-499 -RRB- : an ESI-MS investigation .
552909	0	N-hydroxy-2-acetylaminofluorene	27,58	methemoglobin	62,75	N-hydroxy-2-acetylaminofluorene	methemoglobin	null	3048	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Free radical activation of N-hydroxy-2-acetylaminofluorene by methemoglobin and hydrogen_peroxide .
14521422	0	N-hydroxy-3-phenyl-2-propenamides	0,33	histone_deacetylase	63,82	N-hydroxy-3-phenyl-2-propenamides	histone deacetylase	null	9734	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	N-hydroxy-3-phenyl-2-propenamides as novel inhibitors of human histone_deacetylase with in vivo antitumor activity : discovery of -LRB- 2E -RRB- - N-hydroxy-3 - -LSB- 4 - -LSB- -LSB- -LRB- 2-hydroxyethyl -RRB- -LSB- 2 - -LRB- 1H-indol-3-yl -RRB- ethyl -RSB- amino -RSB- methyl -RSB- phenyl -RSB- -2 - propenamide -LRB- NVP-LAQ824 -RRB- .
8179482	0	N-hydroxyarylamines	50,69	NAT1	112,116	N-hydroxyarylamines	NAT1	null	9	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Metabolic activation of aromatic and heterocyclic N-hydroxyarylamines by wild-type and mutant recombinant human NAT1 and NAT2 acetyltransferases .
19708663	0	N-hydroxybenzimidazole	0,22	LcrF	62,66	N-hydroxybenzimidazole	LcrF	null	1149292(Tax:187410)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	N-hydroxybenzimidazole inhibitors of the transcription factor LcrF in Yersinia : novel antivirulence agents .
15686917	0	N-hydroxycarbamates	29,48	5-Lipoxygenase	0,14	N-hydroxycarbamates	5-Lipoxygenase	null	240	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	5-Lipoxygenase inhibition by N-hydroxycarbamates in dual-function compounds .
21536437	0	N-hydroxyformamide	22,40	ADAM-TS4	55,63	N-hydroxyformamide	ADAM-TS4	null	9507	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Orally active achiral N-hydroxyformamide inhibitors of ADAM-TS4 -LRB- aggrecanase-1 -RRB- and ADAM-TS5 -LRB- aggrecanase-2 -RRB- for the treatment of osteoarthritis .
21094256	0	N-hydroxysuccinyl_esters	66,90	TRPA1	0,5	N-hydroxysuccinyl esters	TRPA1	null	8989	Chemical	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	TRPA1 is activated by direct addition of cysteine residues to the N-hydroxysuccinyl_esters of acrylic and cinnamic_acids .
7853186	0	N-hydroxyurea	54,67	5-lipoxygenase	68,82	N-hydroxyurea	5-lipoxygenase	CHEBI:44423	240	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Optimization of the potency and duration of action of N-hydroxyurea 5-lipoxygenase inhibitors .
9207936	0	N-hydroxyurea	36,49	5-lipoxygenase	50,64	N-hydroxyurea	5-lipoxygenase	CHEBI:44423	240	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Structure-activity relationships of N-hydroxyurea 5-lipoxygenase inhibitors .
10230624	0	N-hydroxyurea	0,13	cyclooxygenase_and_5-lipoxygenase	48,81	N-hydroxyurea	cyclooxygenase and 5-lipoxygenase	CHEBI:44423	240	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	N-hydroxyurea and hydroxamic_acid inhibitors of cyclooxygenase_and_5-lipoxygenase .
10675737	0	N-iminoethyl-L-lysine	87,108	inducible_nitric_oxide_synthase	135,166	N-iminoethyl-L-lysine	inducible nitric oxide synthase	null	100008833(Tax:9986)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Urinary nitrate excretion in cholesterol-fed rabbits : effect of a chronic treatment by N-iminoethyl-L-lysine , a selective inhibitor of inducible_nitric_oxide_synthase .
10798223	0	N-methoxyindole-3-carbinol	0,26	cytochrome_P-450_1A1	58,78	N-methoxyindole-3-carbinol	cytochrome P-450 1A1	MESH:C410766	24296(Tax:10116)	Chemical	Gene	inducer|nsubj|START_ENTITY inducer|nmod|END_ENTITY	N-methoxyindole-3-carbinol is a more efficient inducer of cytochrome_P-450_1A1 in cultured cells than indol-3-carbinol .
25838242	0	N-methy-D-asparate	22,40	GluN2B	4,10	N-methy-D-asparate	GluN2B	null	2904	Chemical	Gene	receptor|amod|START_ENTITY subunit|nmod|receptor subunit|amod|END_ENTITY	The GluN2B subunit of N-methy-D-asparate receptor regulates the radial migration of cortical neurons in vivo .
19324554	0	N-methyl-2-phenylmaleimides	37,64	monoamine_oxidase_B	14,33	N-methyl-2-phenylmaleimides	monoamine oxidase B	null	4129	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of monoamine_oxidase_B by N-methyl-2-phenylmaleimides .
7833794	0	N-methyl-D-aspartate	118,138	AP1	84,87	N-methyl-D-aspartate	AP1	CHEBI:31882	16476(Tax:10090)	Chemical	Gene	administration|nmod|START_ENTITY END_ENTITY|nmod|administration	Rapid and selective enhancement of DNA binding activity of the transcription factor AP1 by systemic administration of N-methyl-D-aspartate in murine hippocampus .
9457665	0	N-methyl-D-aspartate	8,28	APH	0,3	N-methyl-D-aspartate	APH	CHEBI:31882	24206(Tax:10116)	Chemical	Gene	antagonist|amod|START_ENTITY END_ENTITY|appos|antagonist	APH , an N-methyl-D-aspartate receptor antagonist , blocks the metaphit-induced audiogenic_seizures in rats .
10363813	0	N-methyl-D-aspartate	48,68	CA1	90,93	N-methyl-D-aspartate	CA1	CHEBI:31882	310218(Tax:10116)	Chemical	Gene	receptor-channels|amod|START_ENTITY receptor-channels|nmod|neurons neurons|nummod|END_ENTITY	Reduced Mg2 + blockade of synaptically activated N-methyl-D-aspartate receptor-channels in CA1 pyramidal neurons in kainic_acid-lesioned rat hippocampus .
10641754	0	N-methyl-D-aspartate	0,20	CA1	142,145	N-methyl-D-aspartate	CA1	CHEBI:31882	310218(Tax:10116)	Chemical	Gene	antagonists|amod|START_ENTITY effective|nsubj|antagonists effective|advcl|blocking blocking|nmod|dendrites dendrites|nmod|END_ENTITY	N-methyl-D-aspartate receptor antagonists are less effective in blocking long-term potentiation at apical than basal dendrites in hippocampal CA1 of awake rats .
12106254	0	N-methyl-D-aspartate	40,60	CA1	74,77	N-methyl-D-aspartate	CA1	CHEBI:31882	310218(Tax:10116)	Chemical	Gene	Receptors|nsubj|START_ENTITY Receptors|nmod|Neurons Neurons|compound|END_ENTITY	l-Homocysteate Preferentially Activates N-methyl-D-aspartate Receptors to CA1 Rat Hippocampal Neurons .
12150781	0	N-methyl-D-aspartate	80,100	CA1	162,165	N-methyl-D-aspartate	CA1	CHEBI:31882	100720116	Chemical	Gene	receptors|amod|START_ENTITY receptors|nmod|induction induction|nmod|neurons neurons|compound|END_ENTITY	Cooperativity between extracellular adenosine_5 ' - triphosphate and activation of N-methyl-D-aspartate receptors in long-term potentiation induction in hippocampal CA1 neurons .
12626876	0	N-methyl-D-aspartate	25,45	CA1	114,117	N-methyl-D-aspartate	CA1	CHEBI:31882	759	Chemical	Gene	receptors|amod|START_ENTITY changes|nmod|receptors amino_acid|nsubj|changes amino_acid|nmod|area area|compound|END_ENTITY	Chronological changes of N-methyl-D-aspartate receptors and excitatory amino_acid carrier 1 immunoreactivities in CA1 area and subiculum after transient forebrain_ischemia .
1350090	0	N-methyl-D-aspartate	76,96	CA1	42,45	N-methyl-D-aspartate	CA1	CHEBI:31882	310218(Tax:10116)	Chemical	Gene	blockade|amod|START_ENTITY depression|nmod|blockade depression|nmod|END_ENTITY	Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade .
1353442	0	N-methyl-D-aspartate	61,81	CA1	106,109	N-methyl-D-aspartate	CA1	CHEBI:31882	759	Chemical	Gene	complex|amod|START_ENTITY complex|nmod|region region|compound|END_ENTITY	Estradiol selectively regulates agonist binding sites on the N-methyl-D-aspartate receptor complex in the CA1 region of the hippocampus .
1357588	0	N-methyl-D-aspartate	0,20	CA1	73,76	N-methyl-D-aspartate	CA1	CHEBI:31882	310218(Tax:10116)	Chemical	Gene	potentiation|amod|START_ENTITY potentiation|nmod|END_ENTITY	N-methyl-D-aspartate receptor-independent long-term potentiation in area CA1 of rat hippocampus : input-specific induction and preclusion in a non-tetanized pathway .
15489046	0	N-methyl-D-aspartate	29,49	CA1	98,101	N-methyl-D-aspartate	CA1	CHEBI:31882	310218(Tax:10116)	Chemical	Gene	excitation|amod|START_ENTITY excitation|nmod|region region|compound|END_ENTITY	Estradiol increases delayed , N-methyl-D-aspartate receptor-mediated excitation in the hippocampal CA1 region .
15505794	0	N-methyl-D-aspartate	112,132	CA1	56,59	N-methyl-D-aspartate	CA1	CHEBI:31882	310218(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY modulation|nmod|receptors slices|nmod|modulation slices|nsubj|potentiation potentiation|nmod|END_ENTITY	Pregnenolone_sulfate enhances long-term potentiation in CA1 in rat hippocampus slices through the modulation of N-methyl-D-aspartate receptors .
16457957	0	N-methyl-D-aspartate	15,35	CA1	148,151	N-methyl-D-aspartate	CA1	CHEBI:31882	310218(Tax:10116)	Chemical	Gene	potentiation|amod|START_ENTITY involved|nsubj|potentiation involved|nmod|END_ENTITY	Lead inhibited N-methyl-D-aspartate receptor-independent long-term potentiation involved ryanodine-sensitive calcium stores in rat hippocampal area CA1 .
16766131	0	N-methyl-D-aspartate	0,20	CA1	66,69	N-methyl-D-aspartate	CA1	CHEBI:31882	310218(Tax:10116)	Chemical	Gene	potentiation|amod|START_ENTITY potentiation|nmod|region region|compound|END_ENTITY	N-methyl-D-aspartate receptor-dependent long-term potentiation in CA1 region affects synaptic expression of glutamate receptor subunits and associated proteins in the whole hippocampus .
1677768	0	N-methyl-D-aspartate	0,20	CA1	111,114	N-methyl-D-aspartate	CA1	CHEBI:31882	310218(Tax:10116)	Chemical	Gene	activation|amod|START_ENTITY increases|nsubj|activation increases|dep|+ +|nmod|END_ENTITY	N-methyl-D-aspartate receptor activation increases cAMP levels and voltage-gated Ca2 + channel activity in area CA1 of hippocampus .
1704112	0	N-methyl-D-aspartate	39,59	CA1	111,114	N-methyl-D-aspartate	CA1	CHEBI:31882	310218(Tax:10116)	Chemical	Gene	sensitivity|compound|START_ENTITY sensitivity|nmod|END_ENTITY	Proteolytic enzymes do not destroy the N-methyl-D-aspartate -LRB- NMDA -RRB- sensitivity of acutely isolated hippocampal CA1 and CA3 neurons from postnatal rats .
19041927	0	N-methyl-D-aspartate	78,98	CA1	131,134	N-methyl-D-aspartate	CA1	CHEBI:31882	310218(Tax:10116)	Chemical	Gene	subunit|amod|START_ENTITY subunit|nmod|subregion subregion|compound|END_ENTITY	Prenatal morphine alters the synaptic complex of postsynaptic_density_95 with N-methyl-D-aspartate receptor subunit in hippocampal CA1 subregion of rat offspring leading to long-term cognitive_deficits .
19106110	0	N-methyl-D-aspartate	68,88	CA1	102,105	N-methyl-D-aspartate	CA1	CHEBI:31882	759	Chemical	Gene	receptors|amod|START_ENTITY receptors|nmod|neurons neurons|nummod|END_ENTITY	Platelet-derived growth factor selectively inhibits NR2B-containing N-methyl-D-aspartate receptors in CA1 hippocampal neurons .
1933377	0	N-methyl-D-aspartate	78,98	CA1	41,44	N-methyl-D-aspartate	CA1	CHEBI:31882	100720116	Chemical	Gene	application|nmod|START_ENTITY induced|nmod|application induced|nsubj|potentiation potentiation|nmod|region region|compound|END_ENTITY	Synaptic potentiation in the hippocampal CA1 region induced by application of N-methyl-D-aspartate .
20935233	0	N-methyl-D-aspartate	54,74	CA1	111,114	N-methyl-D-aspartate	CA1	CHEBI:31882	310218(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY Down-regulation|nmod|receptors Down-regulation|dep|brake brake|nmod|hyperexcitability hyperexcitability|compound|END_ENTITY	Down-regulation of synaptic GluN2B subunit-containing N-methyl-D-aspartate receptors : a physiological brake on CA1 neuron a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic_acid hyperexcitability during benzodiazepine withdrawal .
21218453	0	N-methyl-D-aspartate	139,159	CA1	116,119	N-methyl-D-aspartate	CA1	CHEBI:31882	759	Chemical	Gene	receptors|amod|START_ENTITY roles|nmod|receptors plasticity|dep|roles plasticity|acl|induced induced|nmod|synapses synapses|compound|END_ENTITY	Bidirectional synaptic plasticity induced by conditioned stimulations with different number of pulse at hippocampal CA1 synapses : roles of N-methyl-D-aspartate and metabotropic glutamate receptors .
22057830	0	N-methyl-D-aspartate	15,35	CA1	87,90	N-methyl-D-aspartate	CA1	CHEBI:31882	310218(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY Involvement|nmod|receptor subunits|nsubj|Involvement subunits|nmod|modification modification|nmod|potentiation potentiation|nummod|END_ENTITY	Involvement of N-methyl-D-aspartate receptor subunits in zinc-mediated modification of CA1 long-term potentiation in the developing hippocampus .
25231980	0	N-methyl-D-aspartate	47,67	CA1	120,123	N-methyl-D-aspartate	CA1	CHEBI:31882	759	Chemical	Gene	responses|amod|START_ENTITY responses|nmod|neurons neurons|compound|END_ENTITY	Glycine induces bidirectional modifications in N-methyl-D-aspartate receptor-mediated synaptic responses in hippocampal CA1 neurons .
2823176	0	N-methyl-D-aspartate	4,24	CA1	54,57	N-methyl-D-aspartate	CA1	CHEBI:31882	310218(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY receptor|nmod|END_ENTITY	The N-methyl-D-aspartate receptor and burst firing of CA1 hippocampal pyramidal neurons .
2848046	0	N-methyl-D-aspartate	155,175	CA1	116,119	N-methyl-D-aspartate	CA1	CHEBI:31882	310218(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY involvement|nmod|receptors END_ENTITY|dep|involvement	Calcium uptake evoked by electrical stimulation is enhanced postischemically and precedes delayed neuronal_death in CA1 of rat hippocampus : involvement of N-methyl-D-aspartate receptors .
2871522	0	N-methyl-D-aspartate	132,152	CA1	106,109	N-methyl-D-aspartate	CA1	CHEBI:31882	310218(Tax:10116)	Chemical	Gene	block|nmod|START_ENTITY block|dobj|firing firing|nmod|neurones neurones|compound|END_ENTITY	2-Amino-5-phosphonovalerate and Co2 + selectively block depolarization and burst firing of rat hippocampal CA1 pyramidal neurones by N-methyl-D-aspartate .
2905437	0	N-methyl-D-aspartate	27,47	CA1	120,123	N-methyl-D-aspartate	CA1	CHEBI:31882	310218(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY demonstration|nmod|receptor mediated|nsubj|demonstration mediated|nmod|END_ENTITY	Direct demonstration of an N-methyl-D-aspartate receptor mediated component of excitatory synaptic transmission in area CA1 of the rat hippocampus .
3533598	0	N-methyl-D-aspartate	35,55	CA1	130,133	N-methyl-D-aspartate	CA1	CHEBI:31882	759	Chemical	Gene	reductions|amod|START_ENTITY reductions|nmod|calcium calcium|nmod|END_ENTITY	Effects of GABA and bicuculline on N-methyl-D-aspartate - and quisqualate-induced reductions in extracellular free calcium in area CA1 of the hippocampal slice .
7529643	0	N-methyl-D-aspartate	0,20	CA1	69,72	N-methyl-D-aspartate	CA1	CHEBI:31882	310218(Tax:10116)	Chemical	Gene	afterdischarges|amod|START_ENTITY afterdischarges|nmod|pyramidal_cells pyramidal_cells|nummod|END_ENTITY	N-methyl-D-aspartate receptor-mediated , prolonged afterdischarges of CA1 pyramidal_cells following transient cerebral_ischemia in the rat hippocampus in vivo .
7675184	0	N-methyl-D-aspartate	72,92	CA1	42,45	N-methyl-D-aspartate	CA1	CHEBI:31882	100720116	Chemical	Gene	antagonists|amod|START_ENTITY presence|nmod|antagonists potentiation|nmod|presence potentiation|nmod|region region|compound|END_ENTITY	Long-term potentiation in the hippocampal CA1 region in the presence of N-methyl-D-aspartate receptor antagonists .
7687331	0	N-methyl-D-aspartate	64,84	CA1	117,120	N-methyl-D-aspartate	CA1	CHEBI:31882	759	Chemical	Gene	openings|amod|START_ENTITY openings|nmod|neurons neurons|compound|END_ENTITY	Glutamate induces long-term increase in the frequency of single N-methyl-D-aspartate channel openings in hippocampal CA1 neurons examined in situ .
7821278	0	N-methyl-D-aspartate	22,42	CA1	94,97	N-methyl-D-aspartate	CA1	CHEBI:31882	12346(Tax:10090)	Chemical	Gene	high|amod|START_ENTITY potassium|amod|high Effects|nmod|potassium Effects|nmod|area area|nummod|END_ENTITY	Effects of glutamate , N-methyl-D-aspartate , high potassium , and hypoxia on unit discharges in CA1 area of hippocampal slices of DBA and C57 mice .
7889125	0	N-methyl-D-aspartate	95,115	CA1	175,178	N-methyl-D-aspartate	CA1	CHEBI:31882	759	Chemical	Gene	potentiation|amod|START_ENTITY potentiation|nmod|neurons neurons|compound|END_ENTITY	Dendritic Ca2 + accumulations and metabotropic glutamate receptor activation associated with an N-methyl-D-aspartate receptor-independent long-term potentiation in hippocampal CA1 neurons .
8618915	0	N-methyl-D-aspartate	7,27	CA1	94,97	N-methyl-D-aspartate	CA1	CHEBI:31882	759	Chemical	Gene	receptors|amod|START_ENTITY receptors|nmod|pathway pathway|nmod|neurons neurons|compound|END_ENTITY	Latent N-methyl-D-aspartate receptors in the recurrent excitatory pathway between hippocampal CA1 pyramidal neurons : Ca -LRB- 2 + -RRB- - dependent activation by blocking A1 adenosine receptors .
8684626	0	N-methyl-D-aspartate	45,65	CA1	82,85	N-methyl-D-aspartate	CA1	CHEBI:31882	310218(Tax:10116)	Chemical	Gene	response|amod|START_ENTITY response|nmod|regions regions|compound|END_ENTITY	Differential effects of sigma ligands on the N-methyl-D-aspartate response in the CA1 and CA3 regions of the dorsal hippocampus : effect of mossy fiber lesioning .
8800380	0	N-methyl-D-aspartate	55,75	CA1	137,140	N-methyl-D-aspartate	CA1	CHEBI:31882	310218(Tax:10116)	Chemical	Gene	component|amod|START_ENTITY component|nmod|neurotransmission neurotransmission|nmod|neurons neurons|compound|END_ENTITY	Acamprosate -LRB- calcium_acetylhomotaurinate -RRB- enhances the N-methyl-D-aspartate component of excitatory neurotransmission in rat hippocampal CA1 neurons in vitro .
11241388	0	N-methyl-D-aspartate	55,75	CA3	102,105	N-methyl-D-aspartate	CA3	CHEBI:31882	54232(Tax:10116)	Chemical	Gene	correlates|nmod|START_ENTITY correlates|dep|levels levels|nmod|neurons neurons|nummod|END_ENTITY	Hippocampal dependent learning ability correlates with N-methyl-D-aspartate -LRB- NMDA -RRB- receptor levels in CA3 neurons of young and aged rats .
12119362	0	N-methyl-D-aspartate	52,72	CA3	106,109	N-methyl-D-aspartate	CA3	CHEBI:31882	54232(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|circuits circuits|compound|END_ENTITY	Mossy fiber Zn2 + spillover modulates heterosynaptic N-methyl-D-aspartate receptor activity in hippocampal CA3 circuits .
1363447	0	N-methyl-D-aspartate	9,29	CA3	122,125	N-methyl-D-aspartate	CA3	CHEBI:31882	54232(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY Role|nmod|receptor hippocampal|nsubj|Role hippocampal|dobj|-RSB- -RSB-|nummod|END_ENTITY	-LSB- Role of N-methyl-D-aspartate receptor in the maintenance of learning-dependent long-term potentiation in rat hippocampal CA3 area -RSB- .
1469629	0	N-methyl-D-aspartate	43,63	CA3	84,87	N-methyl-D-aspartate	CA3	CHEBI:31882	54232(Tax:10116)	Chemical	Gene	response|amod|START_ENTITY response|nmod|hippocampus hippocampus|compound|END_ENTITY	Neuropeptide Y potentiates selectively the N-methyl-D-aspartate response in the rat CA3 dorsal hippocampus .
1469630	0	N-methyl-D-aspartate	31,51	CA3	68,71	N-methyl-D-aspartate	CA3	CHEBI:31882	54232(Tax:10116)	Chemical	Gene	response|amod|START_ENTITY response|nmod|hippocampus hippocampus|nummod|END_ENTITY	Neuropeptide Y potentiates the N-methyl-D-aspartate response in the CA3 dorsal hippocampus .
2153293	0	N-methyl-D-aspartate	35,55	CA3	126,129	N-methyl-D-aspartate	CA3	CHEBI:31882	54232(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY site|nmod|receptor modulates|nsubj|site modulates|dobj|events events|nmod|neurons neurons|compound|END_ENTITY	The allosteric glycine site of the N-methyl-D-aspartate receptor modulates GABAergic-mediated synaptic events in neonatal rat CA3 hippocampal neurons .
2646553	0	N-methyl-D-aspartate	41,61	CA3	95,98	N-methyl-D-aspartate	CA3	CHEBI:31882	54232(Tax:10116)	Chemical	Gene	medium|amod|START_ENTITY medium|nmod|region region|compound|END_ENTITY	Endogenous and network bursts induced by N-methyl-D-aspartate and magnesium free medium in the CA3 region of the hippocampal slice .
2650920	0	N-methyl-D-aspartate	0,20	CA3	91,94	N-methyl-D-aspartate	CA3	CHEBI:31882	54232(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|activity activity|nmod|neurones neurones|compound|END_ENTITY	N-methyl-D-aspartate induces recurrent synchronized burst activity in immature hippocampal CA3 neurones in vitro .
2902900	0	N-methyl-D-aspartate	103,123	CA3	32,35	N-methyl-D-aspartate	CA3	CHEBI:31882	761	Chemical	Gene	antagonists|amod|START_ENTITY blocked|nmod|antagonists blocked|nsubjpass|bursts bursts|acl|elicited elicited|nmod|neurons neurons|nummod|END_ENTITY	Epileptiform bursts elicited in CA3 hippocampal neurons by a variety of convulsants are not blocked by N-methyl-D-aspartate antagonists .
8427011	0	N-methyl-D-aspartate	64,84	CA3	122,125	N-methyl-D-aspartate	CA3	CHEBI:31882	54232(Tax:10116)	Chemical	Gene	response|amod|START_ENTITY modulation|nmod|response involved|nmod|modulation involved|nmod|ligands ligands|nmod|hippocampus hippocampus|compound|END_ENTITY	The cytochromes P-450 are not involved in the modulation of the N-methyl-D-aspartate response by sigma ligands in the rat CA3 dorsal hippocampus .
8848094	0	N-methyl-D-aspartate	27,47	CA3	110,113	N-methyl-D-aspartate	CA3	CHEBI:31882	54232(Tax:10116)	Chemical	Gene	channels|amod|START_ENTITY block|nmod|channels +|dobj|block +|nmod|development development|nmod|neurons neurons|compound|END_ENTITY	Kinetics and Mg2 + block of N-methyl-D-aspartate receptor channels during postnatal development of hippocampal CA3 pyramidal neurons .
8935704	0	N-methyl-D-aspartate	94,114	CA3	152,155	N-methyl-D-aspartate	CA3	CHEBI:31882	54232(Tax:10116)	Chemical	Gene	response|amod|START_ENTITY response|nmod|ligands ligands|nmod|dorsal dorsal|compound|END_ENTITY	Electrophysiological evidence for the implication of cholecystokinin in the modulation of the N-methyl-D-aspartate response by sigma ligands in the rat CA3 dorsal hippocampus .
8943785	0	N-methyl-D-aspartate	67,87	CA3	95,98	N-methyl-D-aspartate	CA3	CHEBI:31882	54232(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|region region|compound|END_ENTITY	Potentiation by dehydroepiandrosterone of the neuronal response to N-methyl-D-aspartate in the CA3 region of the rat dorsal hippocampus : an effect mediated via sigma receptors .
11109007	0	N-methyl-D-aspartate	25,45	GRIN1	73,78	N-methyl-D-aspartate	GRIN1	CHEBI:31882	2902	Chemical	Gene	NR1|amod|START_ENTITY analysis|nmod|NR1 subunit|nsubj|analysis subunit|dobj|gene gene|appos|END_ENTITY	Mutation analysis of the N-methyl-D-aspartate receptor NR1 subunit gene -LRB- GRIN1 -RRB- in schizophrenia .
12610658	0	N-methyl-D-aspartate	18,38	GRIN1	64,69	N-methyl-D-aspartate	GRIN1	CHEBI:31882	2902	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Evidence that the N-methyl-D-aspartate subunit 1 receptor gene -LRB- GRIN1 -RRB- confers susceptibility to bipolar_disorder .
12707933	0	N-methyl-D-aspartate	0,20	GRIN1	48,53	N-methyl-D-aspartate	GRIN1	CHEBI:31882	2902	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	N-methyl-D-aspartate receptor NR1 subunit gene -LRB- GRIN1 -RRB- in schizophrenia : TDT and case-control analyses .
15841096	0	N-methyl-D-aspartate	28,48	GRIN1	76,81	N-methyl-D-aspartate	GRIN1	CHEBI:31882	2902	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	An association study of the N-methyl-D-aspartate receptor NR1 subunit gene -LRB- GRIN1 -RRB- and NR2B subunit gene -LRB- GRIN2B -RRB- in schizophrenia with universal DNA microarray .
16476413	0	N-methyl-D-aspartate	76,96	GRIN1	119,124	N-methyl-D-aspartate	GRIN1	CHEBI:31882	2902	Chemical	Gene	receptor|amod|START_ENTITY variations|nmod|receptor association|nmod|variations subunit|nsubj|association subunit|dobj|END_ENTITY	Significant association between the genetic variations in the 5 ' end of the N-methyl-D-aspartate receptor subunit gene GRIN1 and schizophrenia .
12724619	0	N-methyl-D-aspartate	47,67	GRIN2A	89,95	N-methyl-D-aspartate	GRIN2A	CHEBI:31882	2903	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A microsatellite repeat in the promoter of the N-methyl-D-aspartate receptor 2A subunit -LRB- GRIN2A -RRB- gene suppresses transcriptional activity and correlates with chronic outcome in schizophrenia .
17011703	0	N-methyl-D-aspartate	95,115	GRIN2A	139,145	N-methyl-D-aspartate	GRIN2A	CHEBI:31882	2903	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Significant linkage and association between a functional -LRB- GT -RRB- n polymorphism in promoter of the N-methyl-D-aspartate receptor subunit gene -LRB- GRIN2A -RRB- and schizophrenia .
15841096	0	N-methyl-D-aspartate	28,48	GRIN2B	106,112	N-methyl-D-aspartate	GRIN2B	CHEBI:31882	2904	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	An association study of the N-methyl-D-aspartate receptor NR1 subunit gene -LRB- GRIN1 -RRB- and NR2B subunit gene -LRB- GRIN2B -RRB- in schizophrenia with universal DNA microarray .
16911840	0	N-methyl-D-aspartate	38,58	GRIN2B	81,87	N-methyl-D-aspartate	GRIN2B	CHEBI:31882	2904	Chemical	Gene	receptor|amod|START_ENTITY polymorphisms|nmod|receptor study|nmod|polymorphisms Association|dep|study Association|dep|subunits subunits|appos|END_ENTITY	Association study of polymorphisms in N-methyl-D-aspartate receptor 2B subunits -LRB- GRIN2B -RRB- gene with Korean alcoholism .
17669510	0	N-methyl-D-aspartate	45,65	GRIN2B	94,100	N-methyl-D-aspartate	GRIN2B	CHEBI:31882	2904	Chemical	Gene	receptor|amod|START_ENTITY polymorphisms|nmod|receptor analysis|nmod|polymorphisms subunit|nsubj|analysis subunit|xcomp|gene gene|nsubj|2B 2B|appos|END_ENTITY	Association analysis of polymorphisms in the N-methyl-D-aspartate -LRB- NMDA -RRB- receptor subunit 2B -LRB- GRIN2B -RRB- gene and tardive_dyskinesia in schizophrenia .
18303265	0	N-methyl-D-aspartate	41,61	GRIN2B	24,30	N-methyl-D-aspartate	GRIN2B	CHEBI:31882	2904	Chemical	Gene	receptor|amod|START_ENTITY encoding|dobj|receptor encoding|nsubj|analysis analysis|nmod|END_ENTITY	Association analysis of GRIN2B , encoding N-methyl-D-aspartate receptor 2B subunit , and Alzheimer 's _ disease .
22484476	0	N-methyl-D-aspartate	0,20	GRIN2B	42,48	N-methyl-D-aspartate	GRIN2B	CHEBI:31882	2904	Chemical	Gene	subunit|amod|START_ENTITY associated|nsubj|subunit associated|dep|END_ENTITY	N-methyl-D-aspartate receptor 2B subunit -LRB- GRIN2B -RRB- gene variation is associated with alerting , but not with orienting and conflicting in the Attention Network Test .
24114429	0	N-methyl-D-aspartate	11,31	GRIN2B	47,53	N-methyl-D-aspartate	GRIN2B	CHEBI:31882	2904	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A study of N-methyl-D-aspartate receptor gene -LRB- GRIN2B -RRB- variants as predictors of treatment-resistant major depression .
9547169	0	N-methyl-D-aspartate	52,72	GRIN2B	42,48	N-methyl-D-aspartate	GRIN2B	CHEBI:31882	2904	Chemical	Gene	subunit|amod|START_ENTITY END_ENTITY|appos|subunit	mRNA distribution in adult human brain of GRIN2B , a N-methyl-D-aspartate -LRB- NMDA -RRB- receptor subunit .
19665356	0	N-methyl-D-aspartate	55,75	GRIN3A	85,91	N-methyl-D-aspartate	GRIN3A	CHEBI:31882	116443	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Exomic sequencing of the ionotropic glutamate receptor N-methyl-D-aspartate 3A gene -LRB- GRIN3A -RRB- reveals no association with schizophrenia .
22291020	0	N-methyl-D-aspartate	64,84	GluN2A	85,91	N-methyl-D-aspartate	GluN2A	CHEBI:31882	2903	Chemical	Gene	subunits|amod|START_ENTITY subunits|amod|END_ENTITY	5-Hydroxytryptamine 5HT2C receptors form a protein complex with N-methyl-D-aspartate GluN2A subunits and activate phosphorylation of Src protein to modulate motoneuronal depolarization .
20935233	0	N-methyl-D-aspartate	54,74	GluN2B	28,34	N-methyl-D-aspartate	GluN2B	CHEBI:31882	24410(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Down-regulation of synaptic GluN2B subunit-containing N-methyl-D-aspartate receptors : a physiological brake on CA1 neuron a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic_acid hyperexcitability during benzodiazepine withdrawal .
21768120	0	N-methyl-D-aspartate	126,146	GluN2B	171,177	N-methyl-D-aspartate	GluN2B	CHEBI:31882	2904	Chemical	Gene	receptor|amod|START_ENTITY binding|nmod|receptor II|amod|binding subunit|nsubj|II subunit|dobj|END_ENTITY	Nucleotides and phosphorylation bi-directionally modulate Ca2 + / calmodulin-dependent protein kinase II -LRB- CaMKII -RRB- binding to the N-methyl-D-aspartate -LRB- NMDA -RRB- receptor subunit GluN2B .
22740692	0	N-methyl-D-aspartate	72,92	GluN2B	25,31	N-methyl-D-aspartate	GluN2B	CHEBI:31882	24410(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY trafficking|nmod|receptors controls|dobj|trafficking controls|nsubj|binding binding|nmod|subunit subunit|amod|END_ENTITY	Glutamate binding to the GluN2B subunit controls surface trafficking of N-methyl-D-aspartate -LRB- NMDA -RRB- receptors .
24025330	0	N-methyl-D-aspartate	105,125	GluN2B	151,157	N-methyl-D-aspartate	GluN2B	CHEBI:31882	14812(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY expression|nmod|receptor subunit|nsubj|expression subunit|dobj|END_ENTITY	Presenilin-1 / y-secretase controls glutamate release , tyrosine phosphorylation , and surface expression of N-methyl-D-aspartate receptor -LRB- NMDAR -RRB- subunit GluN2B .
26186074	0	N-methyl-D-aspartate	107,127	GluN2B	81,87	N-methyl-D-aspartate	GluN2B	D016202	2904	Chemical	Gene	receptors|amod|START_ENTITY containing|dobj|receptors subunit|xcomp|containing subunit|nsubj|2-methyltetrahydro-3-benzazepin-1-ols 2-methyltetrahydro-3-benzazepin-1-ols|acl|blocking blocking|dobj|END_ENTITY	Enantiomerically pure 2-methyltetrahydro-3-benzazepin-1-ols selectively blocking GluN2B subunit containing N-methyl-D-aspartate receptors .
11024032	0	N-methyl-D-aspartate	104,124	GluR_epsilon_2	67,81	N-methyl-D-aspartate	GluR epsilon 2	CHEBI:31882	14812(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY subunit|nmod|receptor subunit|amod|END_ENTITY	Characterization of Fyn-mediated tyrosine phosphorylation sites on GluR_epsilon_2 -LRB- NR2B -RRB- subunit of the N-methyl-D-aspartate receptor .
7523101	0	N-methyl-D-aspartate	84,104	GnRH	120,124	N-methyl-D-aspartate	GnRH	CHEBI:31882	2796	Chemical	Gene	START_ENTITY|dep|secretion secretion|compound|END_ENTITY	Nitric_oxide synthesized by gonadotropin-releasing_hormone neurons is a mediator of N-methyl-D-aspartate -LRB- NMDA -RRB- - induced GnRH secretion .
16380382	0	N-methyl-D-aspartate	0,20	JNK	42,45	N-methyl-D-aspartate	JNK	CHEBI:31882	5599	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	N-methyl-D-aspartate blocks activation of JNK and mitochondrial apoptotic pathway induced by potassium deprivation in cerebellar granule cells .
23760271	0	N-methyl-D-aspartate	68,88	Low_density_lipoprotein_receptor-related_protein_1	0,50	N-methyl-D-aspartate	Low density lipoprotein receptor-related protein 1	CHEBI:31882	16971(Tax:10090)	Chemical	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	Low_density_lipoprotein_receptor-related_protein_1 -LRB- LRP1 -RRB- modulates N-methyl-D-aspartate -LRB- NMDA -RRB- receptor-dependent intracellular signaling and NMDA-induced regulation of postsynaptic protein complexes .
10640675	2	N-methyl-D-aspartate	356,376	NMDA	378,382	N-methyl-D-aspartate	REST	CHEBI:31882	19712(Tax:10090)	Chemical	Gene	_|compound|START_ENTITY _|appos|END_ENTITY	The N-methyl-D-aspartate _ -LRB- NMDA -RRB- _ receptor_subunit_type_I _ -LRB- NR1 -RRB- gene contains a consensus sequence for the NRSF/REST binding site -LRB- NRSE/RE1 -RRB- .
8978823	3	N-methyl-D-aspartate	547,567	NMDA	569,573	N-methyl-D-aspartate	AP-5	CHEBI:31882	91056	Chemical	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	We provide evidence that O-2A cells in these preparations express functional N-methyl-D-aspartate -LRB- NMDA -RRB- receptors , most likely as homomeric complexes of the NR1 subunit .
24025330	0	N-methyl-D-aspartate	105,125	NMDAR	136,141	N-methyl-D-aspartate	NMDAR	CHEBI:31882	14810(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Presenilin-1 / y-secretase controls glutamate release , tyrosine phosphorylation , and surface expression of N-methyl-D-aspartate receptor -LRB- NMDAR -RRB- subunit GluN2B .
10750825	0	N-methyl-D-aspartate	26,46	NMDAR1	4,10	N-methyl-D-aspartate	NMDAR1	CHEBI:31882	2902	Chemical	Gene	receptor|amod|START_ENTITY subunit|nmod|receptor subunit|compound|END_ENTITY	The NMDAR1 subunit of the N-methyl-D-aspartate receptor is localized at postsynaptic sites opposite both retinal and cortical terminals in the cat superior colliculus .
1409641	0	N-methyl-D-aspartate	295,315	NMDAR1	79,85	N-methyl-D-aspartate	NMDAR1	CHEBI:31882	24408(Tax:10116)	Chemical	Gene	NMDAR1|amod|START_ENTITY variants|nmod|NMDAR1 encoding|dobj|variants identified|advcl|encoding identified|csubj|Cloning Cloning|nmod|variant variant|nmod|END_ENTITY	Cloning of an apparent splice variant of the rat N-methyl-D-aspartate receptor NMDAR1 with altered sensitivity to polyamines and activators of protein kinase C. Molecular cloning identified complementary DNA species , from a rat ventral midbrain library , encoding apparent splice variants of the N-methyl-D-aspartate -LRB- NMDA -RRB- receptor NMDAR1 -LRB- which we now term NR1a -RRB- .
7622053	0	N-methyl-D-aspartate	53,73	NMDAR1	84,90	N-methyl-D-aspartate	NMDAR1	CHEBI:31882	2902	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Cloning and structure of the gene encoding the human N-methyl-D-aspartate receptor -LRB- NMDAR1 -RRB- .
7706322	0	N-methyl-D-aspartate	62,82	NMDAR1	106,112	N-methyl-D-aspartate	NMDAR1	CHEBI:31882	24408(Tax:10116)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Functional analysis of the proximal 5 ' - flanking region of the N-methyl-D-aspartate receptor subunit gene , NMDAR1 .
8041519	0	N-methyl-D-aspartate	27,47	NMDAR1	49,55	N-methyl-D-aspartate	NMDAR1	CHEBI:31882	24408(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Expression of mRNA for the N-methyl-D-aspartate -LRB- NMDAR1 -RRB- receptor by the enteric neurons of the rat .
8255182	0	N-methyl-D-aspartate	24,44	NMDAR1	46,52	N-methyl-D-aspartate	NMDAR1	CHEBI:31882	24408(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	A splice variant of the N-methyl-D-aspartate -LRB- NMDAR1 -RRB- receptor .
8801272	0	N-methyl-D-aspartate	27,47	NMDAR1	49,55	N-methyl-D-aspartate	NMDAR1	CHEBI:31882	24408(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Expression of mRNA for the N-methyl-D-aspartate -LRB- NMDAR1 -RRB- receptor and vasoactive_intestinal_polypeptide -LRB- VIP -RRB- co-exist in enteric neurons of the rat .
10327164	0	N-methyl-D-aspartate	24,44	NR1	186,189	N-methyl-D-aspartate	NR1	CHEBI:31882	24408(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY expression|nmod|receptors root|nsubj|expression root|dobj|ganglion ganglion|nmod|inflammation inflammation|dep|study study|nmod|subunit subunit|compound|END_ENTITY	Decreased expression of N-methyl-D-aspartate -LRB- NMDA -RRB- receptors in rat dorsal root ganglion following complete Freund 's adjuvant-induced inflammation : an immunocytochemical study for NMDA NR1 subunit .
10581413	0	N-methyl-D-aspartate	48,68	NR1	78,81	N-methyl-D-aspartate	NR1	CHEBI:31882	2902	Chemical	Gene	subunit|amod|START_ENTITY subunit|compound|END_ENTITY	A mutation in the glycine binding pocket of the N-methyl-D-aspartate receptor NR1 subunit alters agonist efficacy .
10809744	0	N-methyl-D-aspartate	30,50	NR1	80,83	N-methyl-D-aspartate	NR1	CHEBI:31882	2902	Chemical	Gene	receptors|amod|START_ENTITY inhibition|nmod|receptors inhibition|nmod|domain domain|compound|END_ENTITY	Reduced ethanol inhibition of N-methyl-D-aspartate receptors by deletion of the NR1 C0 domain or overexpression of alpha-actinin-2 proteins .
11158251	0	N-methyl-D-aspartate	56,76	NR1	37,40	N-methyl-D-aspartate	NR1	CHEBI:31882	24408(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY Expression|nmod|receptor Expression|nmod|subunit subunit|compound|END_ENTITY	Expression of splice variants of the NR1 subunit of the N-methyl-D-aspartate receptor in the normal and injured rat spinal cord .
11238723	0	N-methyl-D-aspartate	24,44	NR1	102,105	N-methyl-D-aspartate	NR1	CHEBI:31882	2902	Chemical	Gene	receptors|amod|START_ENTITY Reduction|nmod|receptors Reduction|nmod|mRNA mRNA|compound|END_ENTITY	Reduction of functional N-methyl-D-aspartate receptors in neurons by RNase P-mediated cleavage of the NR1 mRNA .
11368783	0	N-methyl-D-aspartate	23,43	NR1	4,7	N-methyl-D-aspartate	NR1	CHEBI:31882	2902	Chemical	Gene	receptor|amod|START_ENTITY subunit|nmod|receptor subunit|compound|END_ENTITY	The NR1 subunit of the N-methyl-D-aspartate receptor can be efficiently expressed alone in the cell surface of mammalian cells and is required for the transport of the NR2A subunit .
14530275	0	N-methyl-D-aspartate	55,75	NR1	85,88	N-methyl-D-aspartate	NR1	CHEBI:31882	24408(Tax:10116)	Chemical	Gene	region|amod|START_ENTITY region|compound|END_ENTITY	Apo-calmodulin binds with its C-terminal domain to the N-methyl-D-aspartate receptor NR1 C0 region .
15448144	0	N-methyl-D-aspartate	131,151	NR1	45,48	N-methyl-D-aspartate	NR1	CHEBI:31882	2902	Chemical	Gene	receptor|amod|START_ENTITY enhancement|nmod|receptor critical|nmod|enhancement critical|nsubj|Arginine Arginine|nmod|domain domain|nmod|subunit subunit|compound|END_ENTITY	Arginine 260 of the amino-terminal domain of NR1 subunit is critical for tissue-type_plasminogen_activator-mediated enhancement of N-methyl-D-aspartate receptor signaling .
15890444	0	N-methyl-D-aspartate	75,95	NR1	105,108	N-methyl-D-aspartate	NR1	CHEBI:31882	24408(Tax:10116)	Chemical	Gene	subunits|amod|START_ENTITY subunits|compound|END_ENTITY	Inhibition of protein phosphatase 2B upregulates serine phosphorylation of N-methyl-D-aspartate receptor NR1 subunits in striatal neurons in vivo .
16049015	0	N-methyl-D-aspartate	40,60	NR1	21,24	N-methyl-D-aspartate	NR1	CHEBI:31882	24408(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY subunit|nmod|receptor subunit|compound|END_ENTITY	Transcription of the NR1 subunit of the N-methyl-D-aspartate receptor is down-regulated by excitotoxic stimulation and cerebral_ischemia .
16499494	0	N-methyl-D-aspartate	121,141	NR1	68,71	N-methyl-D-aspartate	NR1	CHEBI:31882	2902	Chemical	Gene	receptors|amod|START_ENTITY inhibition|nmod|receptors subunit|nmod|inhibition subunit|nsubj|Effects Effects|nmod|substitutions substitutions|nmod|domains domains|nmod|END_ENTITY	Effects of amino_acid substitutions in transmembrane domains of the NR1 subunit on the ethanol inhibition of recombinant N-methyl-D-aspartate receptors .
16571972	0	N-methyl-D-aspartate	37,57	NR1	67,70	N-methyl-D-aspartate	NR1	CHEBI:31882	24408(Tax:10116)	Chemical	Gene	subunits|amod|START_ENTITY subunits|compound|END_ENTITY	Propofol inhibits phosphorylation of N-methyl-D-aspartate receptor NR1 subunits in neurons .
17551091	0	N-methyl-D-aspartate	78,98	NR1	108,111	N-methyl-D-aspartate	NR1	CHEBI:31882	14810(Tax:10090)	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Design and evaluation of small interfering RNAs that target expression of the N-methyl-D-aspartate receptor NR1 subunit gene in the spinal cord dorsal horn .
17822844	0	N-methyl-D-aspartate	74,94	NR1	95,98	N-methyl-D-aspartate	NR1	CHEBI:31882	14810(Tax:10090)	Chemical	Gene	subunit|amod|START_ENTITY subunit|compound|END_ENTITY	Decreased_pain response in mice following cortex-specific knockout of the N-methyl-D-aspartate NR1 subunit .
17878266	0	N-methyl-D-aspartate	113,133	NR1	31,34	N-methyl-D-aspartate	NR1	CHEBI:31882	2902	Chemical	Gene	receptors|amod|START_ENTITY inhibition|nmod|receptors determine|dobj|inhibition determine|nsubj|domains domains|nmod|subunits subunits|compound|END_ENTITY	The N-terminal domains of both NR1 and NR2 subunits determine allosteric Zn2 + inhibition and glycine affinity of N-methyl-D-aspartate receptors .
17919302	0	N-methyl-D-aspartate	8,28	NR1	4,7	N-methyl-D-aspartate	NR1	CHEBI:31882	2902	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	The NR1 N-methyl-D-aspartate subunit and brain-derived neurotrophic factor in temporal_lobe_epilepsy hippocampus : a comparison of patients with and without coexisting psychiatric symptoms .
18479834	0	N-methyl-D-aspartate	31,51	NR1	61,64	N-methyl-D-aspartate	NR1	CHEBI:31882	24408(Tax:10116)	Chemical	Gene	subunit|amod|START_ENTITY subunit|compound|END_ENTITY	Preferential relocation of the N-methyl-D-aspartate receptor NR1 subunit in nucleus accumbens neurons that contain dopamine D1 receptors in rats showing an apomorphine-induced sensorimotor gating deficit .
18483226	0	N-methyl-D-aspartate	54,74	NR1	4,7	N-methyl-D-aspartate	NR1	CHEBI:31882	2902	Chemical	Gene	receptor|amod|START_ENTITY coupling|nmod|receptor mediates|dobj|coupling mediates|nsubj|domain domain|compound|END_ENTITY	The NR1 M3 domain mediates allosteric coupling in the N-methyl-D-aspartate receptor .
18633054	0	N-methyl-D-aspartate	56,76	NR1	86,89	N-methyl-D-aspartate	NR1	CHEBI:31882	24408(Tax:10116)	Chemical	Gene	subunit|amod|START_ENTITY subunit|compound|END_ENTITY	Intrathecal clonidine suppresses phosphorylation of the N-methyl-D-aspartate receptor NR1 subunit in spinal dorsal horn neurons of rats with neuropathic_pain .
19452450	0	N-methyl-D-aspartate	77,97	NR1	120,123	N-methyl-D-aspartate	NR1	CHEBI:31882	14810(Tax:10090)	Chemical	Gene	receptors|amod|START_ENTITY receptors|acl|composed composed|nmod|subunits subunits|compound|END_ENTITY	Interference with cellular differentiation by D-serine through antagonism at N-methyl-D-aspartate receptors composed of NR1 and NR3A subunits in chondrocytes .
19602553	0	N-methyl-D-aspartate	70,90	NR1	91,94	N-methyl-D-aspartate	NR1	CHEBI:31882	14810(Tax:10090)	Chemical	Gene	mice|compound|START_ENTITY mice|compound|END_ENTITY	Novel environment and GABA agonists alter event-related potentials in N-methyl-D-aspartate NR1 hypomorphic and wild-type mice .
19671301	0	N-methyl-D-aspartate	37,57	NR1	22,25	N-methyl-D-aspartate	NR1	CHEBI:31882	24408(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY subunit|nmod|receptor subunit|nummod|END_ENTITY	-LSB- Relationship between NR1 subunit of N-methyl-D-aspartate receptor and visceral_hypersensitivity caused by acute restraint stress : experiment with rats -RSB- .
20463582	0	N-methyl-D-aspartate	22,42	NR1	52,55	N-methyl-D-aspartate	NR1	CHEBI:31882	24408(Tax:10116)	Chemical	Gene	subunit|amod|START_ENTITY subunit|compound|END_ENTITY	Gene knockdown of the N-methyl-D-aspartate receptor NR1 subunit with subcutaneous small interfering RNA reduces inflammation-induced nociception in rats .
20966414	0	N-methyl-D-aspartate	97,117	NR1	82,85	N-methyl-D-aspartate	NR1	CHEBI:31882	14810(Tax:10090)	Chemical	Gene	receptors|amod|START_ENTITY Subunit|nmod|receptors Subunit|compound|END_ENTITY	Functional occurrence of the interaction of tissue plasminogen activator with the NR1 Subunit of N-methyl-D-aspartate receptors during stroke .
22711533	0	N-methyl-D-aspartate	138,158	NR1	61,64	N-methyl-D-aspartate	NR1	CHEBI:31882	2902	Chemical	Gene	receptors|amod|START_ENTITY delivery|nmod|receptors regulation|nmod|delivery contribute|nmod|regulation contribute|nsubj|residues residues|nmod|subunits subunits|compound|END_ENTITY	Key amino_acid residues within the third membrane domains of NR1 and NR2 subunits contribute to the regulation of the surface delivery of N-methyl-D-aspartate receptors .
26429674	0	N-methyl-D-aspartate	48,68	NR1	33,36	N-methyl-D-aspartate	NR1	D016202	2902	Chemical	Gene	receptors|amod|START_ENTITY Association|nmod|receptors Association|nmod|antibodies antibodies|nmod|subunit subunit|compound|END_ENTITY	Association of antibodies to the NR1 subunit of N-methyl-D-aspartate receptors with neuropsychiatric_systemic_lupus_erythematosus .
8776668	0	N-methyl-D-aspartate	27,47	NR1	57,60	N-methyl-D-aspartate	NR1	CHEBI:31882	24408(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY pattern|nmod|receptor END_ENTITY|nsubj|pattern	Spatio-temporal pattern of N-methyl-D-aspartate receptor NR1 mRNA expression during postnatal development of visual_structures_of_the_rat_brain .
8863813	0	N-methyl-D-aspartate	14,34	NR1	111,114	N-methyl-D-aspartate	NR1	CHEBI:31882	2902	Chemical	Gene	receptors|amod|START_ENTITY Activation|nmod|receptors Activation|dep|role role|nmod|residue residue|nmod|loop loop|nmod|subunit subunit|compound|END_ENTITY	Activation of N-methyl-D-aspartate receptors by glycine : role of an aspartate residue in the M3-M4 loop of the NR1 subunit .
9020125	0	N-methyl-D-aspartate	59,79	NR1	98,101	N-methyl-D-aspartate	NR1	CHEBI:31882	24408(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY expression|nmod|receptor subunits|nsubj|expression subunits|dobj|END_ENTITY	Differential surface expression and phosphorylation of the N-methyl-D-aspartate receptor subunits NR1 and NR2 in cultured hippocampal neurons .
9030583	0	N-methyl-D-aspartate	81,101	NR1	111,114	N-methyl-D-aspartate	NR1	CHEBI:31882	2902	Chemical	Gene	subunit|amod|START_ENTITY subunit|compound|END_ENTITY	Characterization of protein kinase A and protein_kinase_C phosphorylation of the N-methyl-D-aspartate receptor NR1 subunit using phosphorylation site-specific antibodies .
9666074	0	N-methyl-D-aspartate	47,67	NR1	86,89	N-methyl-D-aspartate	NR1	CHEBI:31882	2902	Chemical	Gene	receptors|amod|START_ENTITY subunits|nmod|receptors Distribution|nmod|subunits Distribution|dep|END_ENTITY	Distribution and expression of the subunits of N-methyl-D-aspartate -LRB- NMDA -RRB- receptors ; NR1 , NR2A and NR2B in hypoxic_newborn_piglet_brains .
10688637	0	N-methyl-D-aspartate	7,27	NR2A	49,53	N-methyl-D-aspartate	NR2A	CHEBI:31882	24409(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|acl|containing containing|dobj|subunits subunits|compound|END_ENTITY	Native N-methyl-D-aspartate receptors containing NR2A and NR2B subunits have pharmacologically distinct competitive antagonist binding sites .
11104776	0	N-methyl-D-aspartate	92,112	NR2A	76,80	N-methyl-D-aspartate	NR2A	CHEBI:31882	2903	Chemical	Gene	complex|amod|START_ENTITY subunit|nmod|complex subunit|nummod|END_ENTITY	Protein kinase C activation modulates alpha-calmodulin kinase II binding to NR2A subunit of N-methyl-D-aspartate receptor complex .
12552130	0	N-methyl-D-aspartate	32,52	NR2A	74,78	N-methyl-D-aspartate	NR2A	CHEBI:31882	14811(Tax:10090)	Chemical	Gene	currents|amod|START_ENTITY loss|nmod|currents loss|nmod|mice mice|compound|END_ENTITY	Developmental loss of miniature N-methyl-D-aspartate receptor currents in NR2A knockout mice .
12759180	0	N-methyl-D-aspartate	124,144	NR2A	107,111	N-methyl-D-aspartate	NR2A	CHEBI:31882	24409(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY subunits|nmod|receptors subunits|nummod|END_ENTITY	Suppression of postsynaptic_density_protein_95 expression attenuates increased tyrosine phosphorylation of NR2A subunits of N-methyl-D-aspartate receptors and interactions of Src and Fyn with NR2A after transient brain_ischemia in rat hippocampus .
12759180	0	N-methyl-D-aspartate	124,144	NR2A	192,196	N-methyl-D-aspartate	NR2A	CHEBI:31882	24409(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY subunits|nmod|receptors phosphorylation|nmod|subunits increased|dobj|phosphorylation increased|nmod|END_ENTITY	Suppression of postsynaptic_density_protein_95 expression attenuates increased tyrosine phosphorylation of NR2A subunits of N-methyl-D-aspartate receptors and interactions of Src and Fyn with NR2A after transient brain_ischemia in rat hippocampus .
12831860	0	N-methyl-D-aspartate	28,48	NR2A	23,27	N-methyl-D-aspartate	NR2A	CHEBI:31882	24409(Tax:10116)	Chemical	Gene	subunit|amod|START_ENTITY subunit|nummod|END_ENTITY	Dark-rearing decreases NR2A N-methyl-D-aspartate receptor subunit in all visual cortical_layers .
15928921	0	N-methyl-D-aspartate	101,121	NR2A	75,79	N-methyl-D-aspartate	NR2A	CHEBI:31882	2903	Chemical	Gene	receptor|amod|START_ENTITY subunits|nmod|receptor subunits|compound|END_ENTITY	Comparative analysis of different competitive antagonists interaction with NR2A and NR2B subunits of N-methyl-D-aspartate -LRB- NMDA -RRB- ionotropic glutamate receptor .
16107147	0	N-methyl-D-aspartate	49,69	NR2A	70,74	N-methyl-D-aspartate	NR2A	CHEBI:31882	2903	Chemical	Gene	subunit|amod|START_ENTITY subunit|compound|END_ENTITY	Development of a three-dimensional model for the N-methyl-D-aspartate NR2A subunit .
17650107	0	N-methyl-D-aspartate	40,60	NR2A	15,19	N-methyl-D-aspartate	NR2A	CHEBI:31882	24409(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Involvement of NR2A - or NR2B-containing N-methyl-D-aspartate receptors in the potentiation of cortical layer 5 pyramidal neurone inputs depends on the developmental stage .
18412616	0	N-methyl-D-aspartate	88,108	NR2A	62,66	N-methyl-D-aspartate	NR2A	CHEBI:31882	14811(Tax:10090)	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Long-term potentiation in the nucleus accumbens requires both NR2A - and NR2B-containing N-methyl-D-aspartate receptors .
19240037	0	N-methyl-D-aspartate	116,136	NR2A	69,73	N-methyl-D-aspartate	NR2A	CHEBI:31882	2903	Chemical	Gene	receptors|amod|START_ENTITY inhibition|nmod|receptors relieve|dobj|inhibition cleaves|xcomp|relieve cleaves|dobj|domain domain|nmod|subunit subunit|compound|END_ENTITY	The serine protease plasmin cleaves the amino-terminal domain of the NR2A subunit to relieve zinc inhibition of the N-methyl-D-aspartate receptors .
21862938	0	N-methyl-D-aspartate	36,56	NR2A	11,15	N-methyl-D-aspartate	NR2A	CHEBI:31882	2903	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Effects of NR2A and NR2B-containing N-methyl-D-aspartate receptors on neuronal-firing properties .
22015741	0	N-methyl-D-aspartate	48,68	NR2A	34,38	N-methyl-D-aspartate	NR2A	CHEBI:31882	24409(Tax:10116)	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Phencyclidine treatment increases NR2A and NR2B N-methyl-D-aspartate receptor subunit expression in rats .
22055014	0	N-methyl-D-aspartate	47,67	NR2A	21,25	N-methyl-D-aspartate	NR2A	CHEBI:31882	2903	Chemical	Gene	cortical_gamma_oscillations|amod|START_ENTITY subunits|nmod|cortical_gamma_oscillations subunits|nsubj|role role|nmod|END_ENTITY	Differential role of NR2A and NR2B subunits in N-methyl-D-aspartate receptor antagonist-induced aberrant cortical_gamma_oscillations .
22958338	0	N-methyl-D-aspartate	122,142	NR2A	152,156	N-methyl-D-aspartate	NR2A	CHEBI:31882	2903	Chemical	Gene	subunit|amod|START_ENTITY subunit|compound|END_ENTITY	NADPH oxidase mediates the oxygen-glucose deprivation/reperfusion-induced increase in the tyrosine phosphorylation of the N-methyl-D-aspartate receptor NR2A subunit in retinoic_acid differentiated SH-SY5Y Cells .
8592141	0	N-methyl-D-aspartate	0,20	NR2A	39,43	N-methyl-D-aspartate	NR2A	CHEBI:31882	24409(Tax:10116)	Chemical	Gene	proteins|amod|START_ENTITY proteins|acl:relcl|distributed distributed|nsubjpass|END_ENTITY	N-methyl-D-aspartate receptor proteins NR2A and NR2B are differentially distributed in the developing rat central nervous system as revealed by subunit-specific antibodies .
8848178	0	N-methyl-D-aspartate	37,57	NR2A	112,116	N-methyl-D-aspartate	NR2A	CHEBI:31882	2903	Chemical	Gene	1a|amod|START_ENTITY expression|nmod|1a requires|nsubj|expression requires|dobj|co-expression co-expression|nmod|subunit subunit|compound|END_ENTITY	Cell surface expression of the human N-methyl-D-aspartate receptor subunit 1a requires the co-expression of the NR2A subunit in transfected cells .
9231720	0	N-methyl-D-aspartate	4,24	NR2A	43,47	N-methyl-D-aspartate	NR2A	CHEBI:31882	2903	Chemical	Gene	receptor|amod|START_ENTITY subunits|nsubj|receptor subunits|dobj|bind bind|compound|END_ENTITY	The N-methyl-D-aspartate receptor subunits NR2A and NR2B bind to the SH2 domains of phospholipase C-gamma .
9316859	0	N-methyl-D-aspartate	19,39	NR2A	61,65	N-methyl-D-aspartate	NR2A	CHEBI:31882	100126660(Tax:8355)	Chemical	Gene	receptors|amod|START_ENTITY receptors|acl|containing containing|dobj|END_ENTITY	Lead inhibition of N-methyl-D-aspartate receptors containing NR2A , NR2C and NR2D subunits .
9739998	0	N-methyl-D-aspartate	47,67	NR2A	85,89	N-methyl-D-aspartate	NR2A	CHEBI:31882	24409(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY induction|nmod|receptor subunit|nsubj|induction subunit|dobj|expression expression|nummod|END_ENTITY	Brain_derived_neurotrophic_factor induction of N-methyl-D-aspartate receptor subunit NR2A expression in cultured rat cortical neurons .
10690753	0	N-methyl-D-aspartate	31,51	NR2B	83,87	N-methyl-D-aspartate	NR2B	CHEBI:31882	2904	Chemical	Gene	receptors|amod|START_ENTITY block|nmod|receptors block|dep|selectivity selectivity|nmod|subunit subunit|compound|END_ENTITY	Felbamate block of recombinant N-methyl-D-aspartate receptors : selectivity for the NR2B subunit .
10764765	0	N-methyl-D-aspartate	112,132	NR2B	92,96	N-methyl-D-aspartate	NR2B	CHEBI:31882	2904	Chemical	Gene	receptor|amod|START_ENTITY subunit|nmod|receptor subunit|compound|END_ENTITY	Mechanism and regulation of calcium/calmodulin-dependent protein kinase II targeting to the NR2B subunit of the N-methyl-D-aspartate receptor .
11024032	0	N-methyl-D-aspartate	104,124	NR2B	83,87	N-methyl-D-aspartate	NR2B	CHEBI:31882	14812(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY subunit|nmod|receptor subunit|appos|END_ENTITY	Characterization of Fyn-mediated tyrosine phosphorylation sites on GluR_epsilon_2 -LRB- NR2B -RRB- subunit of the N-methyl-D-aspartate receptor .
11113309	0	N-methyl-D-aspartate	66,86	NR2B	42,46	N-methyl-D-aspartate	NR2B	CHEBI:31882	14812(Tax:10090)	Chemical	Gene	receptors|amod|START_ENTITY containing|dobj|receptors subunit|xcomp|containing subunit|nsubj|evidence evidence|nmod|involvement involvement|nmod|END_ENTITY	Molecular evidence for the involvement of NR2B subunit containing N-methyl-D-aspartate receptors in the development of morphine-induced place preference .
11123375	0	N-methyl-D-aspartate	157,177	NR2B	199,203	N-methyl-D-aspartate	NR2B	CHEBI:31882	24410(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY site|nmod|receptors pharmacology|nmod|site containing|nsubj|pharmacology containing|dobj|subunits subunits|nummod|END_ENTITY	Use of trifluoroperazine isolates a -LSB- -LRB- 3 -RRB- H -RSB- Ifenprodil binding site in rat brain membranes with the pharmacology of the voltage-independent ifenprodil site on N-methyl-D-aspartate receptors containing NR2B subunits .
12946699	0	N-methyl-D-aspartate	20,40	NR2B	80,84	N-methyl-D-aspartate	NR2B	CHEBI:31882	24410(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY blockade|nmod|receptors induces|nsubj|blockade induces|dobj|trafficking trafficking|acl|synapses synapses|advmod|away away|nmod:npmod|subunits subunits|nummod|END_ENTITY	In vivo blockade of N-methyl-D-aspartate receptors induces rapid trafficking of NR2B subunits away from synapses and out of spines and terminals in adult cortex .
14501261	0	N-methyl-D-aspartate	85,105	NR2B	160,164	N-methyl-D-aspartate	NR2B	CHEBI:31882	24410(Tax:10116)	Chemical	Gene	antagonists|amod|START_ENTITY induced|nmod|antagonists disruption|acl|induced PCP|appos|disruption Substitution|nmod|PCP Substitution|dep|involvement involvement|nmod|END_ENTITY	Substitution for PCP , disruption of prepulse inhibition and hyperactivity induced by N-methyl-D-aspartate receptor antagonists : preferential involvement of the NR2B rather than NR2A subunit .
15150412	0	N-methyl-D-aspartate	45,65	NR2B	31,35	N-methyl-D-aspartate	NR2B	CHEBI:31882	2904	Chemical	Gene	sensitivity|amod|START_ENTITY controls|dobj|sensitivity controls|nsubj|domain domain|nmod|END_ENTITY	A steroid modulatory domain on NR2B controls N-methyl-D-aspartate receptor proton sensitivity .
15500960	0	N-methyl-D-aspartate	40,60	NR2B	61,65	N-methyl-D-aspartate	NR2B	CHEBI:31882	24410(Tax:10116)	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	The ultrastructural localisation of the N-methyl-D-aspartate NR2B receptor subunit in rat lumbar spinal cord .
15659539	0	N-methyl-D-aspartate	26,46	NR2B	99,103	N-methyl-D-aspartate	NR2B	CHEBI:31882	24410(Tax:10116)	Chemical	Gene	currents|amod|START_ENTITY potentiation|nmod|currents potentiation|dep|role role|nmod|kinases kinases|compound|END_ENTITY	Clozapine potentiation of N-methyl-D-aspartate receptor currents in the nucleus accumbens : role of NR2B and protein kinase A/Src kinases .
15854593	0	N-methyl-D-aspartate	96,116	NR2B	80,84	N-methyl-D-aspartate	NR2B	CHEBI:31882	2904	Chemical	Gene	receptor|amod|START_ENTITY subunit|nmod|receptor subunit|compound|END_ENTITY	Transient forebrain_ischemia effects interaction of Src , FAK , and PYK2 with the NR2B subunit of N-methyl-D-aspartate receptor in gerbil hippocampus .
15929985	0	N-methyl-D-aspartate	121,141	NR2B	105,109	N-methyl-D-aspartate	NR2B	CHEBI:31882	2904	Chemical	Gene	receptors|amod|START_ENTITY characterization|nmod|receptors characterization|nmod|synapse-associated_protein-97 synapse-associated_protein-97|nmod|subunit subunit|compound|END_ENTITY	Structural characterization of the intermolecular interactions of synapse-associated_protein-97 with the NR2B subunit of N-methyl-D-aspartate receptors .
16131656	0	N-methyl-D-aspartate	84,104	NR2B	68,72	N-methyl-D-aspartate	NR2B	CHEBI:31882	2904	Chemical	Gene	receptor|amod|START_ENTITY Expression|nmod|receptor Expression|nmod|subunit subunit|compound|END_ENTITY	Expression and characterization of soluble amino-terminal domain of NR2B subunit of N-methyl-D-aspartate receptor .
16172120	0	N-methyl-D-aspartate	111,131	NR2B	141,145	N-methyl-D-aspartate	NR2B	CHEBI:31882	2904	Chemical	Gene	subunits|amod|START_ENTITY subunits|compound|END_ENTITY	Differential modulation of Ca2 + / calmodulin-dependent protein kinase II activity by regulated interactions with N-methyl-D-aspartate receptor NR2B subunits and alpha-actinin .
16549338	0	N-methyl-D-aspartate	0,20	NR2B	30,34	N-methyl-D-aspartate	NR2B	CHEBI:31882	2904	Chemical	Gene	GRIN2B|amod|START_ENTITY GRIN2B|compound|END_ENTITY	N-methyl-D-aspartate receptor NR2B subunit gene GRIN2B in schizophrenia and bipolar_disorder : Polymorphisms and mRNA levels .
17249648	0	N-methyl-D-aspartate	166,186	NR2B	151,155	N-methyl-D-aspartate	NR2B	CHEBI:31882	2904	Chemical	Gene	antagonist|amod|START_ENTITY END_ENTITY|dep|antagonist	Identification and characterization of 4-methylbenzyl_4 - -LSB- -LRB- pyrimidin-2-ylamino -RRB- methyl -RSB- piperidine-1-carboxylate , an orally bioavailable , brain penetrant NR2B selective N-methyl-D-aspartate receptor antagonist .
17331654	0	N-methyl-D-aspartate	109,129	NR2B	93,97	N-methyl-D-aspartate	NR2B	CHEBI:31882	24410(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY subunit|nmod|receptors subunit|compound|END_ENTITY	Sustained metabolic inhibition induces an increase in the content and phosphorylation of the NR2B subunit of N-methyl-D-aspartate receptors and a decrease in glutamate transport in the rat hippocampus in vivo .
17962190	0	N-methyl-D-aspartate	51,71	NR2B	81,85	N-methyl-D-aspartate	NR2B	CHEBI:31882	2904	Chemical	Gene	subunit|amod|START_ENTITY subunit|compound|END_ENTITY	Mind bomb-2 is an E3 ligase that ubiquitinates the N-methyl-D-aspartate receptor NR2B subunit in a phosphorylation-dependent manner .
18380671	0	N-methyl-D-aspartate	33,53	NR2B	13,17	N-methyl-D-aspartate	NR2B	CHEBI:31882	2904	Chemical	Gene	receptor|amod|START_ENTITY subunit|nmod|receptor subunit|compound|END_ENTITY	Role for the NR2B subunit of the N-methyl-D-aspartate receptor in mediating light input to the circadian system .
19011431	0	N-methyl-D-aspartate	111,131	NR2B	88,92	N-methyl-D-aspartate	NR2B	CHEBI:31882	2904	Chemical	Gene	antagonist|amod|START_ENTITY selective|dep|antagonist design|amod|selective design|acl|establish establish|dobj|proof proof|nmod|concept concept|nmod|effects effects|nmod|subunit subunit|compound|END_ENTITY	An innovative design to establish proof of concept of the antidepressant effects of the NR2B subunit selective N-methyl-D-aspartate antagonist , CP-101 ,606 , in patients with treatment-refractory major depressive_disorder .
19815434	0	N-methyl-D-aspartate	12,32	NR2B	50,54	N-methyl-D-aspartate	NR2B	CHEBI:31882	14812(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY role|nmod|receptor subunit|nsubj|role subunit|dobj|END_ENTITY	The role of N-methyl-D-aspartate receptor subunit NR2B in spinal cord in cancer_pain .
20427279	0	N-methyl-D-aspartate	58,78	NR2B	135,139	N-methyl-D-aspartate	NR2B	D016202	2904	Chemical	Gene	receptor|amod|START_ENTITY receptor|acl:relcl|reveals reveals|dobj|role role|nmod|END_ENTITY	Novel approach to probe subunit-specific contributions to N-methyl-D-aspartate -LRB- NMDA -RRB- receptor trafficking reveals a dominant role for NR2B in receptor recycling .
20673310	0	N-methyl-D-aspartate	139,159	NR2B	123,127	N-methyl-D-aspartate	NR2B	CHEBI:31882	2904	Chemical	Gene	receptors|amod|START_ENTITY subunit|nmod|receptors subunit|compound|END_ENTITY	Forelimb dyskinesia mediated by high-frequency stimulation of the subthalamic nucleus is linked to rapid activation of the NR2B subunit of N-methyl-D-aspartate receptors .
20688135	0	N-methyl-D-aspartate	92,112	NR2B	76,80	N-methyl-D-aspartate	NR2B	CHEBI:31882	2904	Chemical	Gene	receptors|amod|START_ENTITY subunit|nmod|receptors subunit|compound|END_ENTITY	Specific determinants of conantokins that dictate their selectivity for the NR2B subunit of N-methyl-D-aspartate receptors .
22179603	0	N-methyl-D-aspartate	0,20	NR2B	78,82	N-methyl-D-aspartate	NR2B	CHEBI:31882	2904	Chemical	Gene	receptor|amod|START_ENTITY governed|nsubjpass|receptor governed|nmod|terminus terminus|nmod|subunit subunit|compound|END_ENTITY	N-methyl-D-aspartate receptor mechanosensitivity is governed by C terminus of NR2B subunit .
22610100	0	N-methyl-D-aspartate	47,67	NR2B	16,20	N-methyl-D-aspartate	NR2B	CHEBI:31882	2904	Chemical	Gene	receptor|amod|START_ENTITY terminus|nmod|receptor terminus|nummod|END_ENTITY	Cleavage of the NR2B subunit amino terminus of N-methyl-D-aspartate -LRB- NMDA -RRB- receptor by tissue_plasminogen_activator : identification of the cleavage site and characterization of ifenprodil and glycine affinities on truncated NMDA receptor .
24464409	0	N-methyl-D-aspartate	14,34	NR2B	35,39	N-methyl-D-aspartate	NR2B	CHEBI:31882	2904	Chemical	Gene	antagonist|amod|START_ENTITY antagonist|compound|END_ENTITY	Effect of the N-methyl-D-aspartate NR2B subunit antagonist ifenprodil on precursor cell proliferation in the hippocampus .
8940188	0	N-methyl-D-aspartate	118,138	NR2B	98,102	N-methyl-D-aspartate	NR2B	CHEBI:31882	2904	Chemical	Gene	receptor|amod|START_ENTITY subunit|nmod|receptor subunit|compound|END_ENTITY	Identification of a phosphorylation site for calcium/calmodulindependent protein kinase II in the NR2B subunit of the N-methyl-D-aspartate receptor .
9368572	0	N-methyl-D-aspartate	60,80	NR2B	29,33	N-methyl-D-aspartate	NR2B	CHEBI:31882	2904	Chemical	Gene	receptor|amod|START_ENTITY antagonist|nmod|receptor antagonist|compound|END_ENTITY	Effect of CP101 ,606 , a novel NR2B subunit antagonist of the N-methyl-D-aspartate receptor , on the volume of ischemic brain_damage off cytotoxic_brain_edema after middle_cerebral_artery_occlusion in the feline brain .
9400004	0	N-methyl-D-aspartate	53,73	NR2B	99,103	N-methyl-D-aspartate	NR2B	CHEBI:31882	24410(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|acl|containing containing|dobj|subunit subunit|compound|END_ENTITY	Ro_25-6981 , a highly potent and selective blocker of N-methyl-D-aspartate receptors containing the NR2B subunit .
15665996	0	N-methyl-D-aspartate	67,87	NR2C	50,54	N-methyl-D-aspartate	NR2C	CHEBI:31882	24411(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY subunits|nmod|receptors subunits|nummod|END_ENTITY	Electrophysiological evidence for the presence of NR2C subunits of N-methyl-D-aspartate receptors in rat neurons of the nucleus tractus solitarius .
21300787	0	N-methyl-D-aspartate	90,110	NR2C	124,128	N-methyl-D-aspartate	NR2C	CHEBI:31882	14813(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Deficiency_of_sorting_nexin_27 -LRB- SNX27 -RRB- leads to growth_retardation and elevated levels of N-methyl-D-aspartate receptor 2C -LRB- NR2C -RRB- .
9377491	0	N-methyl-D-aspartate	39,59	NR2C	77,81	N-methyl-D-aspartate	NR2C	CHEBI:31882	2905	Chemical	Gene	receptor|amod|START_ENTITY regions|nmod|receptor subunit|nsubj|regions subunit|dobj|promoter promoter|compound|END_ENTITY	Tissue specific control regions of the N-methyl-D-aspartate receptor subunit NR2C promoter .
12191494	0	N-methyl-D-aspartate	36,56	NR2D	152,156	N-methyl-D-aspartate	NR2D	CHEBI:31882	14814(Tax:10090)	Chemical	Gene	subunits|amod|START_ENTITY localization|nmod|subunits localization|dep|evidence evidence|nmod|role role|nmod|subunit subunit|compound|END_ENTITY	Immunohistochemical localization of N-methyl-D-aspartate receptor subunits in the adult murine hippocampal formation : evidence for a unique role of the NR2D subunit .
16094258	0	N-methyl-D-aspartate	63,83	NR2D	101,105	N-methyl-D-aspartate	NR2D	CHEBI:31882	2906	Chemical	Gene	receptor|amod|START_ENTITY polymorphisms|nmod|receptor Identification|nmod|polymorphisms subunit|nsubj|Identification subunit|dobj|gene gene|nummod|END_ENTITY	Identification of single-nucleotide polymorphisms in the human N-methyl-D-aspartate receptor subunit NR2D gene , GRIN2D , and association study with schizophrenia .
18592148	0	N-methyl-D-aspartate	39,59	NR2D	69,73	N-methyl-D-aspartate	NR2D	CHEBI:31882	24412(Tax:10116)	Chemical	Gene	subunit|amod|START_ENTITY subunit|compound|END_ENTITY	Vagotomy upregulates expression of the N-methyl-D-aspartate receptor NR2D subunit in the stomach .
7715842	0	N-methyl-D-aspartate	42,62	NR2D	106,110	N-methyl-D-aspartate	NR2D	CHEBI:31882	100126609(Tax:8355)	Chemical	Gene	properties|nmod|START_ENTITY receptors|nsubj|properties receptors|xcomp|containing containing|xcomp|subunit subunit|nsubj|4 4|appos|END_ENTITY	Pharmacological properties of recombinant N-methyl-D-aspartate -LRB- NMDA -RRB- receptors containing the epsilon 4 -LRB- NR2D -RRB- subunit .
9174077	0	N-methyl-D-aspartate	0,20	NR2D	46,50	N-methyl-D-aspartate	NR2D	CHEBI:31882	24412(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|acl|containing containing|dobj|subunit subunit|compound|END_ENTITY	N-methyl-D-aspartate receptors containing the NR2D subunit in the retina are selectively expressed in rod bipolar cells .
9495808	0	N-methyl-D-aspartate	23,43	NR2D	101,105	N-methyl-D-aspartate	NR2D	CHEBI:31882	24412(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|nmod|system system|acl:relcl|contain contain|dobj|subunit subunit|compound|END_ENTITY	Subunit composition of N-methyl-D-aspartate receptors in the central nervous system that contain the NR2D subunit .
12576483	0	N-methyl-D-aspartate	49,69	Pyk2	35,39	N-methyl-D-aspartate	Pyk2	CHEBI:31882	19229(Tax:10090)	Chemical	Gene	complex|amod|START_ENTITY END_ENTITY|nmod|complex	Interaction of the tyrosine kinase Pyk2 with the N-methyl-D-aspartate receptor complex via the Src homology 3 domains of PSD-95 and SAP102 .
12524444	0	N-methyl-D-aspartate	74,94	RACK1	166,171	N-methyl-D-aspartate	RACK1	CHEBI:31882	10399	Chemical	Gene	function|amod|START_ENTITY function|nmod|END_ENTITY	Pituitary adenylate cyclase-activating polypeptide -LRB- PACAP -LRB- 1-38 -RRB- -RRB- enhances N-methyl-D-aspartate receptor function and brain-derived_neurotrophic_factor expression via RACK1 .
17438139	0	N-methyl-D-aspartate	61,81	RhoA	101,105	N-methyl-D-aspartate	RhoA	CHEBI:31882	11848(Tax:10090)	Chemical	Gene	activation|amod|START_ENTITY activation|compound|END_ENTITY	Synaptic_scaffolding_molecule alpha is a scaffold to mediate N-methyl-D-aspartate receptor-dependent RhoA activation in dendrites .
12576483	0	N-methyl-D-aspartate	49,69	Src	95,98	N-methyl-D-aspartate	Src	CHEBI:31882	20779(Tax:10090)	Chemical	Gene	complex|amod|START_ENTITY complex|nmod|END_ENTITY	Interaction of the tyrosine kinase Pyk2 with the N-methyl-D-aspartate receptor complex via the Src homology 3 domains of PSD-95 and SAP102 .
12759180	0	N-methyl-D-aspartate	124,144	Src	175,178	N-methyl-D-aspartate	Src	CHEBI:31882	83805(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|nmod|END_ENTITY	Suppression of postsynaptic_density_protein_95 expression attenuates increased tyrosine phosphorylation of NR2A subunits of N-methyl-D-aspartate receptors and interactions of Src and Fyn with NR2A after transient brain_ischemia in rat hippocampus .
22060915	0	N-methyl-D-aspartate	18,38	Src	52,55	N-methyl-D-aspartate	Src	CHEBI:31882	6714	Chemical	Gene	receptors|amod|START_ENTITY receptors|nmod|END_ENTITY	The regulation of N-methyl-D-aspartate receptors by Src kinase .
10215156	0	N-methyl-D-aspartate	0,20	activator_protein-1	42,61	N-methyl-D-aspartate	activator protein-1	CHEBI:31882	16476(Tax:10090)	Chemical	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	N-methyl-D-aspartate signaling to nuclear activator_protein-1 through mechanisms different from those for kainate signaling in murine brain .
7882030	0	N-methyl-D-aspartate	0,20	alpha-MSH	50,59	N-methyl-D-aspartate	alpha-MSH	CHEBI:31882	24664(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|nmod|END_ENTITY	N-methyl-D-aspartate -LRB- NMDA -RRB- stimulates release of alpha-MSH from the rat hypothalamus through release of nitric_oxide .
17086548	0	N-methyl-D-aspartate	70,90	brain-derived_neurotrophic_factor	8,41	N-methyl-D-aspartate	brain-derived neurotrophic factor	CHEBI:31882	24225(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of brain-derived_neurotrophic_factor in the protective action of N-methyl-D-aspartate in the apoptotic death of cerebellar granule neurons induced by low potassium .
7926821	0	N-methyl-D-aspartate	75,95	hNR1	106,110	N-methyl-D-aspartate	hNR1	CHEBI:31882	2902	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Cloning and sequence analysis of additional splice variants encoding human N-methyl-D-aspartate receptor -LRB- hNR1 -RRB- subunits .
9576960	0	N-methyl-D-aspartate	22,42	p21ras	74,80	N-methyl-D-aspartate	p21ras	CHEBI:31882	15461(Tax:10090)	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Nitric_oxide mediates N-methyl-D-aspartate receptor-induced activation of p21ras .
12355059	0	N-methyl-D-aspartate	63,83	p53	0,3	N-methyl-D-aspartate	p53	CHEBI:31882	22060(Tax:10090)	Chemical	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	p53 regulates apoptotic retinal ganglion cell death induced by N-methyl-D-aspartate .
1531081	0	N-methyl-D-aspartate	27,47	prolactin	95,104	N-methyl-D-aspartate	prolactin	CHEBI:31882	24683(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY role|nmod|receptor Studies|nmod|role Studies|nmod|control control|nmod|secretion secretion|compound|END_ENTITY	Studies of the role of the N-methyl-D-aspartate -LRB- NMDA -RRB- receptor in the hypothalamic control of prolactin secretion .
8921830	0	N-methyl-D-aspartate	11,31	prolactin	51,60	N-methyl-D-aspartate	prolactin	CHEBI:31882	24683(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of N-methyl-D-aspartate and kainic_acid on prolactin secretion in prepubertal female rats .
9242209	0	N-methyl-D-aspartate	21,41	prolactin	88,97	N-methyl-D-aspartate	prolactin	CHEBI:31882	24683(Tax:10116)	Chemical	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|control control|nmod|secretion secretion|compound|END_ENTITY	Interactions between N-methyl-D-aspartate , nitric_oxide and serotonin in the control of prolactin secretion in prepubertal male rats .
1700328	0	N-methyl-D-aspartate	11,31	substance_P	93,104	N-methyl-D-aspartate	substance P	CHEBI:31882	21333(Tax:10090)	Chemical	Gene	antagonists|amod|START_ENTITY Effects|nmod|antagonists Effects|nmod|END_ENTITY	Effects of N-methyl-D-aspartate antagonists and spantide on spinal reflexes and responses to substance_P and capsaicin in isolated spinal cord preparations from mouse and rat .
22610100	0	N-methyl-D-aspartate	47,67	tissue_plasminogen_activator	87,115	N-methyl-D-aspartate	tissue plasminogen activator	CHEBI:31882	100128998	Chemical	Gene	receptor|amod|START_ENTITY receptor|nmod|END_ENTITY	Cleavage of the NR2B subunit amino terminus of N-methyl-D-aspartate -LRB- NMDA -RRB- receptor by tissue_plasminogen_activator : identification of the cleavage site and characterization of ifenprodil and glycine affinities on truncated NMDA receptor .
8842405	0	N-methyl-D-aspartate_glutamate	20,50	NR2A	68,72	N-methyl-D-aspartate glutamate	NR2A	null	2903	Chemical	Gene	receptor|amod|START_ENTITY Distribution|nmod|receptor subunit|nsubj|Distribution subunit|dobj|END_ENTITY	Distribution of the N-methyl-D-aspartate_glutamate receptor subunit NR2A in control and amyotrophic_lateral_sclerosis spinal cord .
22026159	0	N-methyl-D-aspartate_glutamate	95,125	NR2B	135,139	N-methyl-D-aspartate glutamate	NR2B	null	24410(Tax:10116)	Chemical	Gene	subunit|amod|START_ENTITY subunit|compound|END_ENTITY	Ketamine and propofol in combination induce neuroapoptosis and down-regulate the expression of N-methyl-D-aspartate_glutamate receptor NR2B subunit in rat forebrain culture .
21712388	0	N-methyl-D-aspartic_acid	72,96	GluN2B	121,127	N-methyl-D-aspartic acid	GluN2B	CHEBI:31882	2904	Chemical	Gene	protein|amod|START_ENTITY protein|compound|END_ENTITY	Effect of Src kinase phosphorylation on disordered C-terminal_domain of N-methyl-D-aspartic_acid -LRB- NMDA -RRB- receptor subunit GluN2B protein .
24939000	0	N-methyl-D-aspartic_acid	7,31	GluN2B	0,6	N-methyl-D-aspartic acid	GluN2B	CHEBI:31882	2904	Chemical	Gene	subunit|amod|START_ENTITY subunit|nummod|END_ENTITY	GluN2B N-methyl-D-aspartic_acid receptor subunit mediates atorvastatin-Induced neuroprotection after focal cerebral_ischemia .
26777707	0	N-methyl-D-aspartic_acid	0,24	NMDAR1	37,43	N-methyl-D-aspartic acid	NMDAR1	CHEBI:31882	14810(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	N-methyl-D-aspartic_acid receptor 1 -LRB- NMDAR1 -RRB- aggravates secondary inflammatory damage induced by hemin-NLRP3 pathway after intracerebral_hemorrhage .
6428190	0	N-methyl-N-formylhydrazine	0,26	diamine_oxidase	78,93	N-methyl-N-formylhydrazine	diamine oxidase	MESH:C016577	26	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	N-methyl-N-formylhydrazine : a toxic and mutagenic inhibitor of the intestinal diamine_oxidase .
2643488	0	N-methyl-N-nitrosourea	65,87	H-ras	59,64	N-methyl-N-nitrosourea	H-ras	MESH:D008770	293621(Tax:10116)	Chemical	Gene	site|compound|START_ENTITY site|compound|END_ENTITY	Excision repair of O6-methylguanine synthesized at the rat H-ras N-methyl-N-nitrosourea activation site and introduced into Escherichia_coli .
14633655	0	N-methyl-N-nitrosourea	53,75	P-glycoprotein	35,49	N-methyl-N-nitrosourea	P-glycoprotein	MESH:D008770	287115(Tax:10116)	Chemical	Gene	induced|compound|START_ENTITY END_ENTITY|nmod|induced	Effect of PSC_833 , an inhibitor of P-glycoprotein on N-methyl-N-nitrosourea induced mammary carcinogenesis in rats .
21528272	0	N-methyl-N-nitrosourea	36,58	nm23	9,13	N-methyl-N-nitrosourea	nm23	MESH:D008770	4830	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Study of nm23 gene expression in an N-methyl-N-nitrosourea transformed human breast epithelial cell line .
10677604	0	N-methyl-N-nitrosourea	15,37	p53	106,109	N-methyl-N-nitrosourea	p53	MESH:D008770	301300(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of N-methyl-N-nitrosourea and azoxymethane on focal cerebral_infarction and the expression of p53 , p21 proteins .
10945617	0	N-methyl-N-nitrosourea	68,90	p53	119,122	N-methyl-N-nitrosourea	p53	MESH:D008770	7157	Chemical	Gene	MSU-1|nmod|START_ENTITY MSU-1|dep|evidence evidence|nmod|elimination elimination|nmod|END_ENTITY	Malignant transformation of human fibroblast cell strain MSU-1 .1 by N-methyl-N-nitrosourea : evidence of elimination of p53 by homologous recombination .
16257854	0	N-methyl-N-nitrosourea	34,56	p53	113,116	N-methyl-N-nitrosourea	p53	MESH:D008770	22060(Tax:10090)	Chemical	Gene	utility|nmod|START_ENTITY evaluating|dobj|utility evaluating|nmod|control control|nmod|studies studies|nmod|/ /|compound|END_ENTITY	Studies evaluating the utility of N-methyl-N-nitrosourea as a positive control in carcinogenicity studies in the p53 + / - mouse .
7600534	0	N-methyl-N-nitrosourea	115,137	p53	19,22	N-methyl-N-nitrosourea	p53	MESH:D008770	22060(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY lesions|dep|induced lesions|nsubj|occurrence occurrence|nmod|mutations mutations|compound|END_ENTITY	Rare occurrence of p53 and ras gene mutations in preneoplastic and neoplastic mouse endometrial lesions induced by N-methyl-N-nitrosourea and 17_beta-estradiol .
11594735	0	N-methyl-d-asparate	25,44	brain-derived_neurotrophic_factor	66,99	N-methyl-d-asparate	brain-derived neurotrophic factor	null	627	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Restoration of decreased N-methyl-d-asparate receptor activity by brain-derived_neurotrophic_factor in the cultured hippocampal neurons : involvement of cAMP .
15145075	0	N-methyl-d-aspartate	29,49	CA1	138,141	N-methyl-d-aspartate	CA1	CHEBI:31882	310218(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY contribution|nmod|receptors induced|nsubj|contribution induced|nmod|low-frequency_pairing low-frequency_pairing|nmod|cells cells|compound|END_ENTITY	Subthreshold contribution of N-methyl-d-aspartate receptors to long-term potentiation induced by low-frequency_pairing in rat hippocampal CA1 pyramidal cells .
20070378	0	N-methyl-d-aspartate	53,73	GRIN2A	95,101	N-methyl-d-aspartate	GRIN2A	CHEBI:31882	2903	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Functional -LRB- GT -RRB- n polymorphisms in promoter region of N-methyl-d-aspartate receptor 2A subunit -LRB- GRIN2A -RRB- gene affect hippocampal and amygdala volumes .
26876050	0	N-methyl-d-aspartate	32,52	GRIN2B	75,81	N-methyl-d-aspartate	GRIN2B	D016202	2904	Chemical	Gene	receptor|amod|START_ENTITY analysis|nmod|receptor subunit|nsubj|analysis subunit|dobj|END_ENTITY	Genetic association analysis of N-methyl-d-aspartate receptor subunit gene GRIN2B and clinical response to clozapine .
22708890	0	N-methyl-d-aspartate	68,88	GluN2B	50,56	N-methyl-d-aspartate	GluN2B	CHEBI:31882	2904	Chemical	Gene	receptor|amod|START_ENTITY subunit|nmod|receptor subunit|amod|END_ENTITY	Endoplasmic reticulum stress occurs downstream of GluN2B subunit of N-methyl-d-aspartate receptor in mature hippocampal cultures treated with amyloid-b oligomers .
25986190	0	N-methyl-d-aspartate	44,64	GluN2B	99,105	N-methyl-d-aspartate	GluN2B	D016202	2904	Chemical	Gene	type|amod|START_ENTITY antibodies|nmod|type analyses|nmod|antibodies glutamate|nsubj|analyses glutamate|dobj|subunits subunits|appos|GluN1 GluN1|amod|END_ENTITY	Semi-quantitative analyses of antibodies to N-methyl-d-aspartate type glutamate receptor subunits -LRB- GluN2B _ GluN1 -RRB- in the clinical course of Rasmussen_syndrome .
25986190	0	N-methyl-d-aspartate	44,64	GluN2B	99,105	N-methyl-d-aspartate	GluN2B	D016202	2904	Chemical	Gene	type|amod|START_ENTITY antibodies|nmod|type analyses|nmod|antibodies glutamate|nsubj|analyses glutamate|dobj|subunits subunits|appos|GluN1 GluN1|amod|END_ENTITY	Semi-quantitative analyses of antibodies to N-methyl-d-aspartate type glutamate receptor subunits -LRB- GluN2B _ GluN1 -RRB- in the clinical course of Rasmussen_syndrome .
26837414	0	N-methyl-d-aspartate	19,39	NMDAR	50,55	N-methyl-d-aspartate	NMDAR	D016202	14810(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY involvement|nmod|receptor involvement|appos|END_ENTITY	The involvement of N-methyl-d-aspartate receptor -LRB- NMDAR -RRB- subunit NR1 in the pathophysiology of schizophrenia .
15081590	0	N-methyl-d-aspartate	63,83	NR1	101,104	N-methyl-d-aspartate	NR1	CHEBI:31882	24408(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY expression|nmod|receptor subunit|nsubj|expression subunit|dobj|END_ENTITY	Differential expression and ser897 phosphorylation of striatal N-methyl-d-aspartate receptor subunit NR1 in animal models of Parkinson 's _ disease .
15610162	0	N-methyl-d-aspartate	64,84	NR1	29,32	N-methyl-d-aspartate	NR1	CHEBI:31882	24408(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY distribution|nmod|receptor distribution|nmod|subunits subunits|compound|END_ENTITY	Synaptic distribution of the NR1 , NR2A and NR2B subunits of the N-methyl-d-aspartate receptor in the rat lumbar spinal cord revealed with an antigen-unmasking technique .
18598691	0	N-methyl-d-aspartate	42,62	NR1	63,66	N-methyl-d-aspartate	NR1	CHEBI:31882	24408(Tax:10116)	Chemical	Gene	subunit|amod|START_ENTITY subunit|compound|END_ENTITY	Repeated cocaine administration increases N-methyl-d-aspartate NR1 subunit , extracellular signal-regulated kinase and cyclic_AMP response element-binding protein phosphorylation and glutamate release in the rat dorsal striatum .
20594879	0	N-methyl-d-aspartate	26,46	NR1	56,59	N-methyl-d-aspartate	NR1	CHEBI:31882	24408(Tax:10116)	Chemical	Gene	subunits|amod|START_ENTITY subunits|compound|END_ENTITY	Phosphorylation of spinal N-methyl-d-aspartate receptor NR1 subunits by extracellular signal-regulated kinase in dorsal horn neurons and microglia contributes to diabetes-induced painful_neuropathy .
26837414	0	N-methyl-d-aspartate	19,39	NR1	65,68	N-methyl-d-aspartate	NR1	D016202	2902	Chemical	Gene	receptor|amod|START_ENTITY involvement|nmod|receptor subunit|nsubj|involvement subunit|dobj|END_ENTITY	The involvement of N-methyl-d-aspartate receptor -LRB- NMDAR -RRB- subunit NR1 in the pathophysiology of schizophrenia .
18082335	0	N-methyl-d-aspartate	173,193	NR2A	147,151	N-methyl-d-aspartate	NR2A	CHEBI:31882	14811(Tax:10090)	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	alpha-Isoform of calcium-calmodulin-dependent protein kinase II and postsynaptic_density_protein_95 differentially regulate synaptic expression of NR2A - and NR2B-containing N-methyl-d-aspartate receptors in hippocampus .
10785463	0	N-methyl-d-aspartate	81,101	NR2B	57,61	N-methyl-d-aspartate	NR2B	CHEBI:31882	24410(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|nummod|END_ENTITY	Antiparkinsonian actions of CP-101 ,606 , an antagonist of NR2B subunit-containing N-methyl-d-aspartate receptors .
24797707	0	N-methyl-d-aspartate	48,68	NR2B	31,35	N-methyl-d-aspartate	NR2B	CHEBI:31882	14812(Tax:10090)	Chemical	Gene	receptors|amod|START_ENTITY subunits|nmod|receptors subunits|compound|END_ENTITY	Dopamine_D3_receptor-regulated NR2B subunits of N-methyl-d-aspartate receptors in the nucleus accumbens involves in morphine-induced locomotor activity .
26688426	0	N-methyl-d-aspartate	0,20	NR2B	30,34	N-methyl-d-aspartate	NR2B	D016202	24410(Tax:10116)	Chemical	Gene	subunit|amod|START_ENTITY subunit|compound|END_ENTITY	N-methyl-d-aspartate receptor NR2B subunit involved in depression-like behaviours in lithium_chloride-pilocarpine chronic rat_epilepsy model .
15854768	0	N-methyl-d-aspartate	7,27	c-Fos	0,5	N-methyl-d-aspartate	c-Fos	CHEBI:31882	314322(Tax:10116)	Chemical	Gene	receptor|dep|START_ENTITY receptor|compound|END_ENTITY	c-Fos , N-methyl-d-aspartate receptor 2C , GABA-A-alpha1 immonoreactivity , seizure latency and neuronal_injury following single or recurrent neonatal_seizures in hippocampus of Wistar rat .
25754253	0	N-methyl_D-aspartate	54,74	KLF11	120,125	N-methyl D-aspartate	KLF11	CHEBI:31882	313994(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	All trans retinoic_acid -LRB- ATRA -RRB- mediated modulation of N-methyl_D-aspartate receptor -LRB- NMDAR -RRB- and Kruppel_like_factor_11 -LRB- KLF11 -RRB- expressions in the mitigation of ethanol induced alterations in the brain .
19445686	1	N-methyl_D-aspartate	149,169	NMDA	171,175	N-methyl D-aspartate	NR2B	CHEBI:31882	14812(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Activation of N-methyl_D-aspartate -LRB- NMDA -RRB- receptor is important for learning , memory and persistent pain .
18849881	0	N-methyl_D-aspartate	25,45	NR1	55,58	N-methyl D-aspartate	NR1	CHEBI:31882	24408(Tax:10116)	Chemical	Gene	subunit|amod|START_ENTITY subunit|compound|END_ENTITY	GRINL1A colocalizes with N-methyl_D-aspartate receptor NR1 subunit and reduces N-methyl_D-aspartate toxicity .
24083763	0	N-methyl_nitrosourea	30,50	Myc	12,15	N-methyl nitrosourea	Myc	null	24577(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Upregulated Myc expression in N-methyl_nitrosourea -LRB- MNU -RRB- - induced rat mammary tumours .
1964154	0	N-methyl_pyrrolidinone	48,70	insulin-like_growth_factor_I	13,41	N-methyl pyrrolidinone	insulin-like growth factor I	MESH:C063153	24482(Tax:10116)	Chemical	Gene	using|dobj|START_ENTITY END_ENTITY|acl|using	Synthesis of insulin-like_growth_factor_I using N-methyl_pyrrolidinone as the coupling solvent and trifluoromethane_sulphonic_acid cleavage from the resin .
1495013	0	N-methylated	0,12	CCK	36,39	N-methylated	CCK	null	100735029	Chemical	Gene	analogs|amod|START_ENTITY analogs|nmod|END_ENTITY	N-methylated analogs of Ac -LSB- Nle28 ,31 -RSB- CCK -LRB- 26-33 -RRB- : synthesis , activity , and receptor selectivity .
3210027	4	N-methylated_tetrahydro	950,973	2-PP	989,993	N-methylated tetrahydro	MPTP	null	19255(Tax:10090)	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	We exposed C57 black mice , animals very sensitive to the dopaminergic neurotoxicity of MPTP , to prolonged parenteral and oral administration of large doses of 2-PP , and to prolonged parenteral administration of the N-methylated_tetrahydro derivatives of 2-PP and 3-PP .
16792525	0	N-methylprotoporphyrin	46,68	ferrochelatase	28,42	N-methylprotoporphyrin	ferrochelatase	MESH:C028842	2235	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|END_ENTITY	Modulation of inhibition of ferrochelatase by N-methylprotoporphyrin .
6896292	0	N-methylprotoporphyrin	32,54	ferrochelatase	14,28	N-methylprotoporphyrin	ferrochelatase	MESH:C028842	374020(Tax:9031)	Chemical	Gene	IX|compound|START_ENTITY END_ENTITY|nmod|IX	Inhibition of ferrochelatase by N-methylprotoporphyrin IX is not accompanied by delta-aminolevulinic_acid synthetase induction in chick embryo liver cell culture .
10638822	0	N-methylquipazine	54,71	5-HT3_receptor	75,89	N-methylquipazine	5-HT3 receptor	MESH:C109625	79246(Tax:10116)	Chemical	Gene	START_ENTITY|dep|agonist agonist|amod|END_ENTITY	The characterization of the effect of locally applied N-methylquipazine , a 5-HT3_receptor agonist , on extracellular dopamine levels in the anterior medial prefrontal cortex in the rat : an in vivo microdialysis study .
23926691	0	N-n-butyl-3-methoxyquinoxaline-2-carboxamide	33,77	5-HT3_receptor	85,99	N-n-butyl-3-methoxyquinoxaline-2-carboxamide	5-HT3 receptor	null	79246(Tax:10116)	Chemical	Gene	START_ENTITY|dep|antagonist antagonist|amod|END_ENTITY	Anti-depressant like activity of N-n-butyl-3-methoxyquinoxaline-2-carboxamide -LRB- 6o -RRB- a 5-HT3_receptor antagonist .
26118836	0	N-nicotinoyl_tyramine	0,21	MITF	93,97	N-nicotinoyl tyramine	MITF	null	4286	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|suppressing suppressing|dobj|expression expression|amod|END_ENTITY	N-nicotinoyl_tyramine , a novel niacinamide derivative , inhibits melanogenesis by suppressing MITF gene expression .
6533036	0	N-nitrosamines	26,40	cytochrome_P-450	44,60	N-nitrosamines	cytochrome P-450	null	397687(Tax:9823)	Chemical	Gene	inactivation|nmod|START_ENTITY inactivation|nmod|END_ENTITY	Metabolic inactivation of N-nitrosamines by cytochrome_P-450 in vitro and in vivo .
3133123	0	N-nitrosodialkylamines	29,51	UDP-glucuronosyltransferase	87,114	N-nitrosodialkylamines	UDP-glucuronosyltransferase	null	24862(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|amod|END_ENTITY	Effects of administration of N-nitrosodialkylamines and N-nitrodiethylamine on hepatic UDP-glucuronosyltransferase activity in Wistar_rats .
8631147	0	N-nitrosodialkylamines	49,71	cytochrome_P450	8,23	N-nitrosodialkylamines	cytochrome P450	null	25251(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Role Role|nmod|END_ENTITY	Role of cytochrome_P450 in DNA damage induced by N-nitrosodialkylamines in cultured rat hepatocytes .
21947543	0	N-nitrosodimethylamine	14,36	Bax	47,50	N-nitrosodimethylamine	Bax	MESH:D004128	581	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|amod|END_ENTITY	The effect of N-nitrosodimethylamine -LRB- NDMA -RRB- on Bax and Mcl-1 expression in human neutrophils .
12417611	0	N-nitrosodimethylamine	78,100	hepatocyte_growth_factor	14,38	N-nitrosodimethylamine	hepatocyte growth factor	MESH:D004128	24446(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Expression Expression|nmod|mRNA mRNA|compound|END_ENTITY	Expression of hepatocyte_growth_factor mRNA in rat liver cirrhosis induced by N-nitrosodimethylamine as evidenced by in situ RT-PCR .
10592097	0	N-nitrosoethylurea	144,162	neu	14,17	N-nitrosoethylurea	neu	null	13866(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Activation Activation|nmod|END_ENTITY	Activation of neu by missense point mutation in the transmembrane domain in schwannomas induced in C3H/HeNCr mice by transplacental exposure to N-nitrosoethylurea .
16518644	0	N-nitrosofenfluramine	11,32	CD-1	96,100	N-nitrosofenfluramine	CD-1	null	111334(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|mice mice|compound|END_ENTITY	Effects of N-nitrosofenfluramine , a component of Chinese dietary supplement for weight loss , on CD-1 mice .
15547733	0	N-nitrosomethylbenzylamine	72,98	CPT-11	22,28	N-nitrosomethylbenzylamine	CPT-11	MESH:C014707	963084(Tax:115711)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|effect effect|nmod|END_ENTITY	Suppressive effect of CPT-11 on rat esophageal tumorigenesis induced by N-nitrosomethylbenzylamine .
15264214	0	N-nitrosomethylbenzylamine	46,72	Inducible_nitric_oxide_synthase	0,31	N-nitrosomethylbenzylamine	Inducible nitric oxide synthase	MESH:C014707	24599(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Inducible_nitric_oxide_synthase expression in N-nitrosomethylbenzylamine -LRB- NMBA -RRB- - induced rat esophageal tumorigenesis .
1387549	0	N-oleoyl_heparin	0,16	plasmin	53,60	N-oleoyl heparin	plasmin	null	5340	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	N-oleoyl_heparin inhibits the amidolytic activity of plasmin and urokinase .
19901198	0	N-oleoyldopamine	0,16	GPR119	72,78	N-oleoyldopamine	GPR119	MESH:C488796	236781(Tax:10090)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|activation activation|nmod|END_ENTITY	N-oleoyldopamine enhances glucose homeostasis through the activation of GPR119 .
19013073	0	N-phenyl-1-arylamide	78,98	BACE_1	145,151	N-phenyl-1-arylamide	BACE 1	null	23621	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Identification of pharmacophore model , synthesis and biological evaluation of N-phenyl-1-arylamide and N-phenylbenzenesulfonamide derivatives as BACE_1 inhibitors .
19720877	0	N-phenyl_pyridinone	40,59	p38_mitogen-activated_protein_kinase	73,109	N-phenyl pyridinone	p38 mitogen-activated protein kinase	null	1432	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|nmod|END_ENTITY	Anti-inflammatory properties of a novel N-phenyl_pyridinone inhibitor of p38_mitogen-activated_protein_kinase : preclinical-to-clinical translation .
12530673	0	N-proopiomelanocortin	10,31	cyclin_D1	85,94	N-proopiomelanocortin	cyclin D1	null	100144763(Tax:9940)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of N-proopiomelanocortin -LRB- 1-77 -RRB- and -LRB- 1-49 -RRB- infusions on adrenal expression of cyclin_D1 in the fetal sheep .
22728921	0	N-propionyl-4-S-cysteaminylphenol	49,82	tyrosinase	86,96	N-propionyl-4-S-cysteaminylphenol	tyrosinase	MESH:C114098	22173(Tax:10090)	Chemical	Gene	START_ENTITY|appos|substrate substrate|amod|END_ENTITY	Mechanism of putative neo-antigen formation from N-propionyl-4-S-cysteaminylphenol , a tyrosinase substrate , in melanoma models .
15026042	0	N-propylurea_3-benzylpiperidines	13,45	CCR3	84,88	N-propylurea 3-benzylpiperidines	CCR3	null	1232	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Discovery of N-propylurea_3-benzylpiperidines as selective CC_chemokine_receptor-3 -LRB- CCR3 -RRB- antagonists .
15471866	0	N-retinylidene-phosphatidylethanolamine	0,39	ABCA4	123,128	N-retinylidene-phosphatidylethanolamine	ABCA4	MESH:C497343	24	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	N-retinylidene-phosphatidylethanolamine is the preferred retinoid substrate for the photoreceptor-specific ABC transporter ABCA4 -LRB- ABCR -RRB- .
25250980	0	N-ribosyl	60,69	hCD157	92,98	N-ribosyl	hCD157	null	683	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	A pre-steady state and steady state kinetic analysis of the N-ribosyl hydrolase activity of hCD157 .
11377181	0	N-substituted_N-nitrosohydroxylamines	13,50	tyrosinase	77,87	N-substituted N-nitrosohydroxylamines	tyrosinase	null	7299	Chemical	Gene	Synthesis|nmod|START_ENTITY Synthesis|nmod|inhibitors inhibitors|nmod|END_ENTITY	Synthesis of N-substituted_N-nitrosohydroxylamines as inhibitors of mushroom tyrosinase .
23481650	0	N-substituted_azaindoles	0,24	Cdc7	49,53	N-substituted azaindoles	Cdc7	null	8317	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	N-substituted_azaindoles as potent inhibitors of Cdc7 kinase .
9714307	0	N-substituted_azoles	24,44	CYP3A	74,79	N-substituted azoles	CYP3A	null	170509(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Influence of some novel N-substituted_azoles and pyridines on rat hepatic CYP3A activity .
24649802	0	N-substituted_guanidines	30,54	neuraminidase	65,78	N-substituted guanidines	neuraminidase	null	4758	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Oseltamivir analogues bearing N-substituted_guanidines as potent neuraminidase inhibitors .
19583260	0	N-substituted_maleimide	37,60	monoglyceride_lipase	86,106	N-substituted maleimide	monoglyceride lipase	null	11343	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Synthesis and in vitro evaluation of N-substituted_maleimide derivatives as selective monoglyceride_lipase inhibitors .
23242742	0	N-substituted_pyrazoline	38,62	MAO-A	78,83	N-substituted pyrazoline	MAO-A	null	4128	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Insights into the binding mode of new N-substituted_pyrazoline derivatives to MAO-A : docking and quantum chemical calculations .
2385759	0	N-substituted_tripeptide_trifluoromethyl_ketones	42,90	human_leukocyte_elastase	14,38	N-substituted tripeptide trifluoromethyl ketones	human leukocyte elastase	null	1991	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of human_leukocyte_elastase by N-substituted_tripeptide_trifluoromethyl_ketones .
8765690	1	N-t-butyl-a-phenyl-nitrone	150,176	catalase	212,220	N-t-butyl-a-phenyl-nitrone	catalase	null	24248(Tax:10116)	Chemical	Gene	copper-ions|dep|START_ENTITY copper-ions|amod|superoxide superoxide|amod|END_ENTITY	Kinetics and influence of ascorbic_acid , glutathione , dimethylsulfoxide , N-t-butyl-a-phenyl-nitrone , copper-ions and a copper complex , catalase , superoxide dismutase , hexobarbital and aniline .
19591457	0	N-tosyl-L-phenylalanine_chloromethyl_ketone	0,43	NF-kappaB	53,62	N-tosyl-L-phenylalanine chloromethyl ketone	NF-kappaB	CHEBI:9642	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	N-tosyl-L-phenylalanine_chloromethyl_ketone inhibits NF-kappaB activation by blocking specific cysteine residues of IkappaB_kinase_beta and p65/RelA .
17493356	0	N-tosyl-L-phenylalnylchloromethyl_ketone	11,51	nuclear_transcription_factor-kappaB	87,122	N-tosyl-L-phenylalnylchloromethyl ketone	nuclear transcription factor-kappaB	null	4790	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Effect of N-tosyl-L-phenylalnylchloromethyl_ketone and dexamethasone on expression of nuclear_transcription_factor-kappaB in childhood acute_lymphoblastic_leukemia and its significance -RSB- .
982548	2	N-tritylmorpholine	174,192	snail	230,235	N-tritylmorpholine	snail	MESH:C001958	6615	Chemical	Gene	using|dobj|START_ENTITY using|nmod|END_ENTITY	The attack on the snail hosts , using N-tritylmorpholine , and the effect on transmission from snail to man .
23108437	0	N2	164,166	CO2	155,158	N2	CO2	null	717	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	A microporous metal-organic framework containing an exceptional four-connecting 4 -LRB- 2 -RRB- 6 -LRB- 4 -RRB- topology and a combined effect for highly selective adsorption of CO2 over N2 .
20625002	0	N2-fixing_cyanobacterium_Trichodesmium_IMS101	41,86	CO2	20,23	N2-fixing cyanobacterium Trichodesmium IMS101	CO2	null	717	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Combined effects of CO2 and light on the N2-fixing_cyanobacterium_Trichodesmium_IMS101 : a mechanistic view .
15329878	0	N2O	0,3	CO2	54,57	N2O	CO2	CHEBI:17045	717	Chemical	Gene	influence|nsubj|START_ENTITY influence|nmod|measurements measurements|nmod|END_ENTITY	N2O influence on isotopic measurements of atmospheric CO2 .
15880632	0	N2O	42,45	CO2	87,90	N2O	CO2	CHEBI:17045	717	Chemical	Gene	interference|nmod|START_ENTITY adjust|nmod|interference adjust|nmod|measurements measurements|nmod|END_ENTITY	Methods to adjust for the interference of N2O on delta13C and delta18O measurements of CO2 from soil mineralization .
16676323	0	N2O	7,10	CO2	74,77	N2O	CO2	CHEBI:17045	717	Chemical	Gene	used|nmod|START_ENTITY used|nmod|analysis analysis|nmod|END_ENTITY	On the N2O correction used for mass spectrometric analysis of atmospheric CO2 .
16890333	2	N2O	382,385	CO2	450,453	N2O	CO2	CHEBI:17045	717	Chemical	Gene	fluxes|nmod|START_ENTITY reacted|nsubj|fluxes reacted|advcl|responded responded|nsubj|fluxes fluxes|nmod|END_ENTITY	Bimonthly measurements in 2002-2004 showed that the daily fluxes of N2O , CH4 and CO2 reacted mainly to elevated O3 , while the fluxes of CO2 also responded to elevated CO2 .
17304825	0	N2O	30,33	CO2	20,23	N2O	CO2	CHEBI:17045	717	Chemical	Gene	START_ENTITY|nsubj|dynamics dynamics|nmod|CH4 CH4|compound|END_ENTITY	-LSB- Annual dynamics of CO2 , CH4 , N2O emissions from freshwater marshes and affected by nitrogen fertilization -RSB- .
1809303	0	N2O	14,17	CO2	73,76	N2O	CO2	CHEBI:17045	717	Chemical	Gene	effect|nmod|START_ENTITY mediated|nsubjpass|effect mediated|nmod|END_ENTITY	The effect of N2O on the oxyhemoglobin dissociation curve is mediated by CO2 .
19694782	0	N2O	113,116	CO2	68,71	N2O	CO2	CHEBI:17045	717	Chemical	Gene	offset|nmod|START_ENTITY offset|nsubjpass|sink sink|compound|END_ENTITY	A review of nitrogen enrichment effects on three biogenic GHGs : the CO2 sink may be largely offset by stimulated N2O and CH4 emission .
7925335	0	N2O	92,95	CO2	83,86	N2O	CO2	CHEBI:17045	717	Chemical	Gene	insufflation|compound|START_ENTITY END_ENTITY|nmod|insufflation	Haemodynamic effects of pneumoperitoneum for laparoscopic surgery : a comparison of CO2 with N2O insufflation .
824297	0	N3im-methyl-thyrotropin	22,45	Prolactin	0,9	N3im-methyl-thyrotropin	Prolactin	null	5617	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Prolactin response to N3im-methyl-thyrotropin releasing hormone in euthyroid subjects .
9629467	0	N4-substituted_arylpiperazine	104,133	5-HT1A_receptor	134,149	N4-substituted arylpiperazine	5-HT1A receptor	null	3350	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|amod|END_ENTITY	Theoretical descriptors in quantitative structure-affinity and selectivity relationship study of potent N4-substituted_arylpiperazine 5-HT1A_receptor antagonists .
25678016	0	N6-benzoyladenine	57,74	BRD4	96,100	N6-benzoyladenine	BRD4	null	23476	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	Discovery and structure-activity relationship studies of N6-benzoyladenine derivatives as novel BRD4 inhibitors .
23260322	0	N6-cyclohexyladenosine	31,53	Adenosine_A1_receptor	0,21	N6-cyclohexyladenosine	Adenosine A1 receptor	MESH:C027513	29290(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Adenosine_A1_receptor agonist , N6-cyclohexyladenosine , protects myelin and induces remyelination in an experimental model of rat optic chiasm demyelination ; electrophysiological and histopathological studies .
11673028	0	N6-cyclohexyladenosine	48,70	CA1	80,83	N6-cyclohexyladenosine	CA1	MESH:C027513	310218(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|region region|compound|END_ENTITY	Anticonvulsant effect of bilateral injection of N6-cyclohexyladenosine into the CA1 region of the hippocampus in amygdala-kindled rats .
3555117	0	N6-cyclohexyladenosine	27,49	Renin	0,5	N6-cyclohexyladenosine	Renin	MESH:C027513	24715(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|amod|END_ENTITY	Renin secretory effects of N6-cyclohexyladenosine : effects of dietary sodium .
22002720	0	N6-methyladenosine	0,18	FTO	81,84	N6-methyladenosine	FTO	MESH:C010223	79068	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO .
7086420	0	N6-methyladenosine	11,29	phenylethanolamine_N-methyltransferase	50,88	N6-methyladenosine	phenylethanolamine N-methyltransferase	MESH:C010223	24661(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|synthesis synthesis|nmod|END_ENTITY	Effects of N6-methyladenosine on the synthesis of phenylethanolamine_N-methyltransferase in cultured explants of rat adrenal medulla .
23730746	0	N8-GP	50,55	FVIII	43,48	N8-GP	FVIII	null	14069(Tax:10090)	Chemical	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Prolonged effect of a new O-glycoPEGylated FVIII -LRB- N8-GP -RRB- in a murine saphenous vein bleeding model .
22020217	0	NAADP	8,13	CD38	0,4	NAADP	CD38	MESH:C024376	952	Chemical	Gene	enzyme|compound|START_ENTITY END_ENTITY|dep|enzyme	CD38 : a NAADP degrading enzyme .
17126899	7	NACOS	1480,1485	JNK	1435,1438	NACOS	p65	null	5970	Chemical	Gene	effect|nmod|START_ENTITY involved|nmod|effect involved|nsubjpass|END_ENTITY	Pre-treating ECs with NACOS inhibited the TNF-alpha-induced JNK activation , suggesting that JNK was involved in the inhibitory effect of NACOS on TNF-alpha-induced E-selectin expression .
22843771	0	NAD	104,107	15-hydroxyprostaglandin_dehydrogenase	119,156	NAD	15-hydroxyprostaglandin dehydrogenase	MESH:D009243	15446(Tax:10090)	Chemical	Gene	+|compound|START_ENTITY +|amod|END_ENTITY	Lipopolysaccharide-induced murine embryonic resorption involves nitric_oxide-mediated inhibition of the NAD + - dependent 15-hydroxyprostaglandin_dehydrogenase .
1424803	0	NAD	50,53	ADPRT	84,89	NAD	ADPRT	MESH:D009243	142	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Fluorescence in situ mapping of the human nuclear NAD + ADP-ribosyltransferase gene -LRB- ADPRT -RRB- and two secondary sites to human chromosomal bands 1q42 , 13q34 , and 14q24 .
15465812	0	NAD	77,80	AMP-activated_protein_kinase	36,64	NAD	AMP-activated protein kinase	MESH:D009243	5564	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|activity activity|amod|END_ENTITY	Biochemical regulation of mammalian AMP-activated_protein_kinase activity by NAD and NADH .
23832197	0	NAD	80,83	AdhP	30,34	NAD	AdhP	MESH:D009243	946036(Tax:511145)	Chemical	Gene	Structure|nmod|START_ENTITY Structure|nmod|END_ENTITY	Structure of Escherichia_coli AdhP -LRB- ethanol-inducible dehydrogenase -RRB- with bound NAD .
26485210	0	NAD	27,30	NAMPT	0,5	NAD	NAMPT	MESH:D009243	10135	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|compound|END_ENTITY	NAMPT and NAMPT-controlled NAD metabolism in vascular repair .
19661458	0	NAD	71,74	Nicotinamide_phosphoribosyltransferase	0,38	NAD	Nicotinamide phosphoribosyltransferase	MESH:D009243	59027(Tax:10090)	Chemical	Gene	synthesis|compound|START_ENTITY regulates|nmod|synthesis regulates|nsubj|END_ENTITY	Nicotinamide_phosphoribosyltransferase regulates cell survival through NAD + synthesis in cardiac myocytes .
16516847	0	NAD	23,26	TNF	0,3	NAD	TNF	MESH:D009243	7124	Chemical	Gene	metabolism|compound|START_ENTITY regulates|dobj|metabolism regulates|nsubj|END_ENTITY	TNF regulates cellular NAD + metabolism in primary macrophages .
19372760	0	NAD	0,3	Wlds	36,40	NAD	Wlds	MESH:D009243	22406(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	NAD and axon_degeneration : from the Wlds gene to neurochemistry .
6087893	0	NAD	103,106	cytochrome_c	56,68	NAD	cytochrome c	MESH:D009243	54205	Chemical	Gene	transfer|nmod|START_ENTITY transfer|nmod|END_ENTITY	Energetics of ATP-driven reverse electron transfer from cytochrome_c to fumarate and from succinate to NAD in submitochondrial particles .
9493264	0	NAD	25,28	deoxyhypusine_synthase	46,68	NAD	deoxyhypusine synthase	MESH:D009243	1725	Chemical	Gene	complex|compound|START_ENTITY complex|nmod|END_ENTITY	Crystal structure of the NAD complex of human deoxyhypusine_synthase : an enzyme with a ball-and-chain mechanism for blocking the active site .
15210723	0	NAD	82,85	glycerol-3-phosphate_dehydrogenase	97,131	NAD	glycerol-3-phosphate dehydrogenase	MESH:D009243	854651(Tax:4932)	Chemical	Gene	+|compound|START_ENTITY +|amod|END_ENTITY	Distinct intracellular localization of Gpd1p and Gpd2p , the two yeast isoforms of NAD + - dependent glycerol-3-phosphate_dehydrogenase , explains their different contributions to redox-driven glycerol production .
18452539	0	NAD	34,37	glycerol-3-phosphate_dehydrogenase	49,83	NAD	glycerol-3-phosphate dehydrogenase	MESH:D009243	854651(Tax:4932)	Chemical	Gene	+|compound|START_ENTITY Cloning|nmod|+ Cloning|dep|gene gene|amod|END_ENTITY	Cloning and characterization of a NAD + - dependent glycerol-3-phosphate_dehydrogenase gene from Candida glycerinogenes , an industrial glycerol producer .
20014039	0	NAD	70,73	glycerol-3-phosphate_dehydrogenase	34,68	NAD	glycerol-3-phosphate dehydrogenase	MESH:D009243	854651(Tax:4932)	Chemical	Gene	+|compound|START_ENTITY gene|appos|+ gene|amod|END_ENTITY	Cloning and characterization of a glycerol-3-phosphate_dehydrogenase -LRB- NAD + -RRB- gene from the halotolerant yeast Pichia_farinosa .
8923738	0	NAD	81,84	glycerol-3-phosphate_dehydrogenase	45,79	NAD	glycerol-3-phosphate dehydrogenase	MESH:D009243	854651(Tax:4932)	Chemical	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	Reduced pyruvate decarboxylase and increased glycerol-3-phosphate_dehydrogenase -LSB- NAD + -RSB- levels enhance glycerol production in Saccharomyces_cerevisiae .
9171333	0	NAD	29,32	glycerol_3-phosphate_dehydrogenase	44,78	NAD	glycerol 3-phosphate dehydrogenase	MESH:D009243	854651(Tax:4932)	Chemical	Gene	+|compound|START_ENTITY +|amod|END_ENTITY	The two isoenzymes for yeast NAD + - dependent glycerol_3-phosphate_dehydrogenase encoded by GPD1 and GPD2 have distinct roles in osmoadaptation and redox regulation .
23529657	0	NADH	146,150	Alcohol_Dehydrogenase	68,89	NADH	Alcohol Dehydrogenase	MESH:D009243	10327	Chemical	Gene	catalyzed|nmod|START_ENTITY catalyzed|nmod|END_ENTITY	The kinetics behavior of the reduction of formaldehyde catalyzed by Alcohol_Dehydrogenase -LRB- ADH -RRB- and partial uncompetitive substrate inhibition by NADH .
8187280	0	NADH	26,30	Angiotensin_II	0,14	NADH	Angiotensin II	MESH:D009243	183	Chemical	Gene	activity|compound|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells .
4068710	1	NADH	43,47	C17-20	76,82	NADH	C17-20	MESH:D009243	1035502(Tax:199310)	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	XX -- Effect of NADH on 17 alpha-hydroxypregnene C17-20 lyase activity .
26549640	0	NADH	0,4	CD39	23,27	NADH	CD39	MESH:D009243	953	Chemical	Gene	START_ENTITY|dobj|expression expression|compound|END_ENTITY	NADH oxidase-dependent CD39 expression by CD8 -LRB- + -RRB- T cells modulates interferon_gamma responses via generation of adenosine .
16668941	0	NADH	79,83	Cytochrome_c	34,46	NADH	Cytochrome c	MESH:D009243	100277932(Tax:4577)	Chemical	Gene	Activity|nmod|START_ENTITY Activity|compound|END_ENTITY	Expression in Escherichia_coli of Cytochrome_c Reductase Activity from a Maize NADH : Nitrate Reductase Complementary DNA .
10734052	0	NADH	48,52	Deoxyhypusine_synthase	0,22	NADH	Deoxyhypusine synthase	MESH:D009243	1725	Chemical	Gene	generates|dobj|START_ENTITY generates|nsubj|END_ENTITY	Deoxyhypusine_synthase generates and uses bound NADH in a transient hydride transfer mechanism .
14695918	0	NADH	70,74	ECTO-NOX	84,92	NADH	ECTO-NOX	MESH:D009243	51592	Chemical	Gene	oxidase|compound|START_ENTITY oxidase|appos|END_ENTITY	Specificity of coenzyme Q inhibition of an aging-related cell surface NADH oxidase -LRB- ECTO-NOX -RRB- that generates superoxide .
19073440	0	NADH	55,59	GSK3beta	26,34	NADH	GSK3beta	MESH:D009243	2932	Chemical	Gene	results|nmod|START_ENTITY results|amod|END_ENTITY	Unregulated mitochondrial GSK3beta activity results in NADH : ubiquinone oxidoreductase deficiency .
6761340	0	NADH	42,46	Insulin	0,7	NADH	Insulin	MESH:D009243	3630	Chemical	Gene	control|nmod|START_ENTITY control|compound|END_ENTITY	Insulin control of a transplasma membrane NADH dehydrogenase in erythrocyte membranes .
1473724	0	NADH	18,22	ND6	48,51	NADH	ND6	MESH:D009243	807640(Tax:9031)	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	The mitochondrial NADH dehydrogenase subunit 6 -LRB- ND6 -RRB- gene in Murres : relevance to phylogenetic and population studies among birds .
9707444	0	NADH	47,51	ND6	18,21	NADH	ND6	MESH:D009243	17722(Tax:10090)	Chemical	Gene	dehydrogenase|compound|START_ENTITY subunit|nmod|dehydrogenase subunit|compound|END_ENTITY	The mtDNA-encoded ND6 subunit of mitochondrial NADH dehydrogenase is essential for the assembly of the membrane arm and the respiratory function of the enzyme .
9742104	0	NADH	144,148	ND6	171,174	NADH	ND6	MESH:D009243	4541	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	The deafness-associated mitochondrial DNA mutation at position 7445 , which affects tRNASer -LRB- UCN -RRB- precursor processing , has long-range effects on NADH dehydrogenase subunit ND6 gene expression .
19076229	0	NADH	49,53	NDH-II	69,75	NADH	NDH-II	MESH:D009243	1660	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	Identification of new inhibitors for alternative NADH dehydrogenase -LRB- NDH-II -RRB- .
16706641	0	NADH	27,31	Ndi1	47,51	NADH	Ndi1	MESH:D009243	854919(Tax:4932)	Chemical	Gene	dehydrogenase|nsubj|START_ENTITY dehydrogenase|xcomp|diseases diseases|dep|END_ENTITY	Can a single subunit yeast NADH dehydrogenase -LRB- Ndi1 -RRB- remedy diseases caused by respiratory complex I defects ?
20435911	0	NADH	24,28	Ndi1	43,47	NADH	Ndi1	MESH:D009243	854919(Tax:4932)	Chemical	Gene	START_ENTITY|ccomp|confers confers|nsubj|END_ENTITY	Expression of the yeast NADH dehydrogenase Ndi1 in Drosophila confers increased lifespan independently of dietary restriction .
22949654	0	NADH	27,31	Ndi1	47,51	NADH	Ndi1	MESH:D009243	854919(Tax:4932)	Chemical	Gene	dehydrogenase|compound|START_ENTITY structure|nmod|dehydrogenase structure|appos|END_ENTITY	The structure of the yeast NADH dehydrogenase -LRB- Ndi1 -RRB- reveals overlapping binding sites for water - and lipid-soluble substrates .
26173916	0	NADH	50,54	Ndi1	70,74	NADH	Ndi1	MESH:D009243	854919(Tax:4932)	Chemical	Gene	dehydrogenase|compound|START_ENTITY dehydrogenase|appos|END_ENTITY	New complexes containing the internal alternative NADH dehydrogenase -LRB- Ndi1 -RRB- in mitochondria of Saccharomyces_cerevisiae .
11418099	0	NADH	48,52	PSST	23,27	NADH	PSST	MESH:D009243	374291	Chemical	Gene	subunits|nmod|START_ENTITY subunits|compound|END_ENTITY	Functional coupling of PSST and ND1 subunits in NADH : ubiquinone oxidoreductase established by photoaffinity labeling .
20889970	0	NADH	14,18	Pos5p	27,32	NADH	Pos5p	MESH:D009243	855913(Tax:4932)	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	Mitochondrial NADH kinase , Pos5p , is required for efficient iron-sulfur cluster biogenesis in Saccharomyces_cerevisiae .
11450848	0	NADH	168,172	alcohol_dehydrogenase	70,91	NADH	alcohol dehydrogenase	MESH:D009243	10327	Chemical	Gene	polymorphisms|appos|START_ENTITY polymorphisms|nmod|genes genes|nmod|glutathione_S-transferase glutathione_S-transferase|compound|END_ENTITY	Catalog of 434 single-nucleotide polymorphisms -LRB- SNPs -RRB- in genes of the alcohol_dehydrogenase , glutathione_S-transferase , and nicotinamide_adenine_dinucleotide , reduced -LRB- NADH -RRB- ubiquinone oxidoreductase families .
18585217	0	NADH	30,34	alcohol_dehydrogenase	168,189	NADH	alcohol dehydrogenase	MESH:D009243	10327	Chemical	Gene	oxidation|nmod|START_ENTITY loaded|nsubj|oxidation loaded|dobj|poly poly|dep|film film|acl|modified modified|dobj|electrode electrode|nmod|END_ENTITY	Electrocatalytic oxidation of NADH at gold nanoparticles loaded poly -LRB- 3,4-ethylenedioxythiophene -RRB- - poly -LRB- styrene_sulfonic_acid -RRB- film modified electrode and integration of alcohol_dehydrogenase for alcohol sensing .
3426694	0	NADH	140,144	alcohol_dehydrogenase	168,189	NADH	alcohol dehydrogenase	MESH:D009243	78959(Tax:10116)	Chemical	Gene	oxidation|compound|START_ENTITY rate|nmod|oxidation concentration|nmod|rate effect|nmod|concentration rats|dep|effect determining|nmod|rats Rate|acl|determining catalyzed|nsubj|Rate catalyzed|nmod|END_ENTITY	Rate determining factors of ethanol oxidation in hepatocytes from starved and fed rats : effect of acetaldehyde concentration on the rate of NADH oxidation catalyzed by alcohol_dehydrogenase .
3569292	0	NADH	31,35	alcohol_dehydrogenase	73,94	NADH	alcohol dehydrogenase	MESH:D009243	10327	Chemical	Gene	effects|nmod|START_ENTITY +|nsubj|effects +|advcl|ionizing ionizing|nmod|END_ENTITY	Electrostatic effects of bound NADH and NAD + on ionizing groups in liver alcohol_dehydrogenase .
7011796	0	NADH	10,14	alcohol_dehydrogenase	55,76	NADH	alcohol dehydrogenase	MESH:D009243	10327	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of NADH on the pKa of zinc-bound water in liver alcohol_dehydrogenase .
9432004	0	NADH	13,17	alcohol_dehydrogenase	35,56	NADH	alcohol dehydrogenase	MESH:D009243	10327	Chemical	Gene	Mechanism|nmod|START_ENTITY transfer|nsubj|Mechanism transfer|advcl|END_ENTITY	Mechanism of NADH transfer between alcohol_dehydrogenase and glyceraldehyde-3-phosphate_dehydrogenase .
16502325	0	NADH	60,64	ceruloplasmin	75,88	NADH	ceruloplasmin	MESH:D009243	526230(Tax:9913)	Chemical	Gene	oxidation|nmod|START_ENTITY study|nmod|oxidation study|nmod|END_ENTITY	A kinetic study on the phenothiazine dependent oxidation of NADH by bovine ceruloplasmin .
7462192	0	NADH	60,64	cytochrome_P-450	78,94	NADH	cytochrome P-450	MESH:D009243	4051	Chemical	Gene	transfer|nmod|START_ENTITY transfer|nmod|END_ENTITY	Immunochemical study on the route of electron transfer from NADH and NADPH to cytochrome_P-450 of liver microsomes .
10391884	0	NADH	36,40	glyceraldehyde-3-phosphate_dehydrogenase	57,97	NADH	glyceraldehyde-3-phosphate dehydrogenase	MESH:D009243	2597	Chemical	Gene	modification|amod|START_ENTITY modification|nmod|END_ENTITY	Thiols mediate superoxide-dependent NADH modification of glyceraldehyde-3-phosphate_dehydrogenase .
7918597	0	NADH	57,61	lipoxygenase	25,37	NADH	lipoxygenase	MESH:D009243	547836(Tax:3847)	Chemical	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	Superoxide generation by lipoxygenase in the presence of NADH and NADPH .
1344194	0	NADH	66,70	methemoglobin	27,40	NADH	methemoglobin	MESH:D009243	3048	Chemical	Gene	reduction|nmod|START_ENTITY reduction|nmod|END_ENTITY	-LSB- Nonenzymatic reduction of methemoglobin by free radical forms of NADH and riboflavin -RSB- .
17440754	0	NADH	0,4	xanthine_oxidoreductase	45,68	NADH	xanthine oxidoreductase	MESH:D009243	7498	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	NADH oxidase activity of rat and human liver xanthine_oxidoreductase : potential role in superoxide production .
9182988	0	NADH	0,4	xanthine_oxidoreductase	31,54	NADH	xanthine oxidoreductase	MESH:D009243	7498	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	NADH oxidase activity of human xanthine_oxidoreductase -- generation of superoxide anion .
16660485	0	NADH-Nitrate	0,12	Reductase	13,22	NADH-Nitrate	Reductase	null	547911(Tax:3847)	Chemical	Gene	Inhibitor|compound|START_ENTITY Inhibitor|compound|END_ENTITY	NADH-Nitrate Reductase Inhibitor from Soybean Leaves .
21220430	0	NADH-ubiquinone	37,52	Ndi1	69,73	NADH-ubiquinone	Ndi1	null	854919(Tax:4932)	Chemical	Gene	oxidoreductase|amod|START_ENTITY oxidoreductase|appos|END_ENTITY	Reaction mechanism of single subunit NADH-ubiquinone oxidoreductase -LRB- Ndi1 -RRB- from Saccharomyces_cerevisiae : evidence for a ternary complex mechanism .
25742418	5	NADH_quinone	985,997	NQO1	1024,1028	NADH quinone	Nrf2	null	4780	Chemical	Gene	subunit|amod|START_ENTITY subunit|appos|END_ENTITY	After translocation , Nrf2 subsequently binds to the antioxidant response element -LRB- ARE -RRB- , up-regulated heme_oxygenase-1 -LRB- HO-1 -RRB- , and NADH_quinone oxidoreductase subunit 1 -LRB- NQO1 -RRB- , which may be considered as an antioxidative response to TCBQ-intoxication .
16192277	0	NADP	55,59	MJ0917	0,6	NADP	MJ0917	MESH:D009249	1451806(Tax:243232)	Chemical	Gene	kinase|compound|START_ENTITY kinase|nsubj|END_ENTITY	MJ0917 in archaeon Methanococcus_jannaschii is a novel NADP phosphatase/NAD kinase .
18546376	0	NADP	14,18	NAD_kinase	45,55	NADP	NAD kinase	MESH:D009249	65220	Chemical	Gene	Production|nmod|START_ENTITY Production|nmod|END_ENTITY	Production of NADP by immobilized cells with NAD_kinase .
10819972	0	NADP	15,19	P450_reductase	49,63	NADP	P450 reductase	MESH:D009249	33883(Tax:7227)	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of NADP -LRB- H -RRB- with oxidized and reduced P450_reductase during catalysis .
8135	0	NADP	23,27	ferredoxin-NADP_reductase	44,69	NADP	ferredoxin-NADP reductase	MESH:D009249	2232	Chemical	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	A lysyl residue at the NADP binding site of ferredoxin-NADP_reductase .
16413406	1	NADPH	139,144	Angiotensin_II	113,127	NADPH	angiotensin II	MESH:D009249	183	Chemical	Gene	activity|amod|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates NADPH oxidase activity in vascular cells .
25909649	0	NADPH	67,72	BLI-3	33,38	NADPH	BLI-3	MESH:D009249	171608(Tax:6239)	Chemical	Gene	Domain|compound|START_ENTITY Localization|nmod|Domain Localization|nmod|END_ENTITY	Localization of the Dual Oxidase BLI-3 and Characterization of Its NADPH Oxidase Domain during Infection of Caenorhabditis_elegans .
19885004	0	NADPH	104,109	CD36	48,52	NADPH	CD36	MESH:D009249	12491(Tax:10090)	Chemical	Gene	Production|compound|START_ENTITY Expression|nmod|Production Expression|compound|END_ENTITY	Cilostazol Attenuates 4-hydroxynonenal-enhanced CD36 Expression on Murine Macrophages via Inhibition of NADPH Oxidase-derived Reactive Oxygen Species Production .
25038863	0	NADPH	37,42	CPR	70,73	NADPH	CPR	MESH:D009249	5447	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Molecular population genetics of the NADPH cytochrome_P450_reductase -LRB- CPR -RRB- gene in Anopheles minimus .
16899095	0	NADPH	0,5	CYBA	15,19	NADPH	CYBA	MESH:D009249	1535	Chemical	Gene	oxidase|compound|START_ENTITY oxidase|appos|END_ENTITY	NADPH oxidase -LRB- CYBA -RRB- and FcgammaR polymorphisms as risk factors for aggressive periodontitis : a case-control association study .
21045268	0	NADPH	94,99	CYBA	69,73	NADPH	CYBA	MESH:D009249	1535	Chemical	Gene	polymorphism|nmod|START_ENTITY polymorphism|compound|END_ENTITY	Relation between development of cardiovascular_disease and the C242T CYBA polymorphism of the NADPH oxidase in ESRD patients .
12101222	0	NADPH	64,69	Cytosolic_phospholipase_A2	0,26	NADPH	Cytosolic phospholipase A2	MESH:D009249	5321	Chemical	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Cytosolic_phospholipase_A2 -LRB- cPLA2 -RRB- regulation of human monocyte NADPH oxidase activity .
23545780	0	NADPH	98,103	DUOX2	92,97	NADPH	DUOX2	MESH:D009249	50506	Chemical	Gene	response|compound|START_ENTITY response|compound|END_ENTITY	IFNb/TNFa synergism induces a non-canonical STAT2/IRF9-dependent pathway triggering a novel DUOX2 NADPH oxidase-mediated airway antiviral response .
24853759	0	NADPH	52,57	Duox2	108,113	NADPH	Duox2	MESH:D009249	214593(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|activity activity|nmod|END_ENTITY	Hypothyroidism-associated missense mutation impairs NADPH oxidase activity and intracellular trafficking of Duox2 .
15778391	0	NADPH	0,5	ERK1/2	69,75	NADPH	ERK1/2	MESH:D009249	5595;5594	Chemical	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	NADPH oxidase-derived reactive_oxygen_species-mediated activation of ERK1/2 is required for apoptosis of human neutrophils induced by Entamoeba_histolytica .
16554353	0	NADPH	48,53	ERK1/2	158,164	NADPH	ERK1/2	MESH:D009249	50689;116590	Chemical	Gene	oxidase|compound|START_ENTITY activation|nmod|oxidase feeding|dobj|activation ethanol|acl|feeding ethanol|dep|role role|nmod|oxygen oxygen|nmod|activation activation|compound|END_ENTITY	Chronic ethanol feeding increases activation of NADPH oxidase by lipopolysaccharide in rat Kupffer cells : role of increased reactive oxygen in LPS-stimulated ERK1/2 activation and TNF-alpha production .
16554353	0	NADPH	48,53	ERK1/2	158,164	NADPH	ERK1/2	MESH:D009249	50689;116590	Chemical	Gene	oxidase|compound|START_ENTITY activation|nmod|oxidase feeding|dobj|activation ethanol|acl|feeding ethanol|dep|role role|nmod|oxygen oxygen|nmod|activation activation|compound|END_ENTITY	Chronic ethanol feeding increases activation of NADPH oxidase by lipopolysaccharide in rat Kupffer cells : role of increased reactive oxygen in LPS-stimulated ERK1/2 activation and TNF-alpha production .
17365667	0	NADPH	108,113	ERK1/2	80,86	NADPH	ERK1/2	MESH:D009249	26417;26413	Chemical	Gene	leading|xcomp|START_ENTITY activates|advcl|leading activates|dobj|END_ENTITY	Abrupt reoxygenation of microvascular endothelial cells after hypoxia activates ERK1/2 and JNK1 , leading to NADPH oxidase-dependent oxidant production .
17958324	7	NADPH	1097,1102	ERK1/2	1133,1139	NADPH	ERK1/2	MESH:D009249	5595;5594	Chemical	Gene	nicotinamide_adenine_dinucleotide_phosphate|appos|START_ENTITY nicotinamide_adenine_dinucleotide_phosphate|amod|oxidase oxidase|nmod|phosphorylation phosphorylation|compound|END_ENTITY	We observed the dose-dependent inhibitory effect of diphenyleneiodonium -LRB- DPI -RRB- , an inhibitor of reduced nicotinamide_adenine_dinucleotide_phosphate -LRB- NADPH -RRB- oxidase on the ET-1-enhanced ERK1/2 phosphorylation in ESMC .
21256191	0	NADPH	104,109	ERK1/2	20,26	NADPH	ERK1/2	MESH:D009249	26417;26413	Chemical	Gene	oxidase|compound|START_ENTITY involvement|nmod|oxidase regulation|dep|involvement regulation|nmod|activation activation|nummod|END_ENTITY	Redox regulation of ERK1/2 activation induced by sphingosine_1-phosphate in fibroblasts : involvement of NADPH oxidase and platelet-derived growth factor receptor .
24573389	0	NADPH	24,29	ERK1/2	14,20	NADPH	ERK1/2	MESH:D009249	50689;116590	Chemical	Gene	species|amod|START_ENTITY END_ENTITY|nmod|species	Activation of ERK1/2 by NADPH oxidase-originated reactive oxygen species mediates uric_acid-induced mesangial cell proliferation .
12855428	0	NADPH	24,29	Gp91phox	0,8	NADPH	Gp91phox	MESH:D009249	13058(Tax:10090)	Chemical	Gene	contributes|xcomp|START_ENTITY contributes|nsubj|END_ENTITY	Gp91phox contributes to NADPH oxidase activity in aortic fibroblasts but not smooth muscle cells .
23144758	0	NADPH	0,5	HIF-1a	44,50	NADPH	HIF-1a	MESH:D009249	3091	Chemical	Gene	oxidase|nsubj|START_ENTITY oxidase|dobj|expression expression|amod|END_ENTITY	NADPH oxidase 4 mediates insulin-stimulated HIF-1a and VEGF expression , and angiogenesis in vitro .
18263583	0	NADPH	3,8	HSCARG	25,31	NADPH	HSCARG	MESH:D009249	57407	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	An NADPH sensor protein -LRB- HSCARG -RRB- down-regulates nitric_oxide synthesis by association with argininosuccinate_synthetase and is essential for epithelial cell viability .
19254724	0	NADPH	0,5	HSCARG	36,42	NADPH	HSCARG	MESH:D009249	57407	Chemical	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	NADPH is an allosteric regulator of HSCARG .
23527155	0	NADPH	16,21	HSCARG	0,6	NADPH	HSCARG	MESH:D009249	57407	Chemical	Gene	inhibits|xcomp|START_ENTITY inhibits|nsubj|END_ENTITY	HSCARG inhibits NADPH oxidase activity through regulation of the expression of p47phox .
25881670	0	NADPH	24,29	HSP70	65,70	NADPH	HSP70	MESH:D009249	3308	Chemical	Gene	oxidase|compound|START_ENTITY oxidase|appos|END_ENTITY	The regulatory roles of NADPH oxidase , intra - and extra-cellular HSP70 in pancreatic islet function , dysfunction and diabetes .
22231145	0	NADPH	107,112	Heme_oxygenase_1	0,16	NADPH	Heme oxygenase 1	MESH:D009249	15368(Tax:10090)	Chemical	Gene	species/activator|compound|START_ENTITY decrease|nmod|species/activator expression|nmod|decrease attenuates|dobj|expression attenuates|nsubj|END_ENTITY	Heme_oxygenase_1 attenuates interleukin-1b-induced cytosolic_phospholipase_A2 expression via a decrease in NADPH oxidase/reactive oxygen species/activator _ protein_1 activation in rheumatoid_arthritis synovial fibroblasts .
26988591	0	NADPH	33,38	High_Mobility_Group_Box_1	57,82	NADPH	High Mobility Group Box 1	MESH:D009249	3146	Chemical	Gene	Production|compound|START_ENTITY Production|compound|END_ENTITY	Mesenchymal Stem Cells Attenuate NADPH Oxidase-Dependent High_Mobility_Group_Box_1 Production and Inhibit Abdominal_Aortic_Aneurysms .
16181054	0	NADPH	45,50	IFN-gamma	14,23	NADPH	IFN-gamma	MESH:D009249	3458	Chemical	Gene	system|compound|START_ENTITY effect|nmod|system effect|nmod|END_ENTITY	The effect of IFN-gamma and TNF-alpha on the NADPH oxidase system of human colostrum_macrophages , blood monocytes , and THP-1 cells .
11024060	0	NADPH	44,49	Kv_beta_2	17,26	NADPH	Kv beta 2	MESH:D009249	399149(Tax:8355)	Chemical	Gene	site|nmod|START_ENTITY site|amod|END_ENTITY	Mutations in the Kv_beta_2 binding site for NADPH and their effects on Kv1 .4 .
22401855	0	NADPH	71,76	Microphthalmia-associated_transcription_factor	0,46	NADPH	Microphthalmia-associated transcription factor	MESH:D009249	17342(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Microphthalmia-associated_transcription_factor modulates expression of NADPH oxidase type 4 : a negative regulator of melanogenesis .
21526340	0	NADPH	0,5	NAD_kinase	22,32	NADPH	NAD kinase	MESH:D009249	65220	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	NADPH regulates human NAD_kinase , a NADP ___ - biosynthetic enzyme .
22550069	0	NADPH	37,42	NAD_kinase	0,10	NADPH	NAD kinase	MESH:D009249	100125370(Tax:10116)	Chemical	Gene	pool|compound|START_ENTITY size|nmod|pool regulates|dobj|size regulates|nsubj|END_ENTITY	NAD_kinase regulates the size of the NADPH pool and insulin secretion in pancreatic b-cells .
23939432	0	NADPH	42,47	NDB1	63,67	NADPH	NDB1	MESH:D009249	828937(Tax:3702)	Chemical	Gene	dehydrogenase|compound|START_ENTITY dehydrogenase|appos|END_ENTITY	Suppression of the external mitochondrial NADPH dehydrogenase , NDB1 , in Arabidopsis_thaliana affects central metabolism and vegetative growth .
16407283	0	NADPH	31,36	NF-kappaB	0,9	NADPH	NF-kappaB	MESH:D009249	18033(Tax:10090)	Chemical	Gene	oxidase|nsubj|START_ENTITY regulates|xcomp|oxidase regulates|nsubj|END_ENTITY	NF-kappaB regulates phagocytic NADPH oxidase by inducing the expression of gp91phox .
17403674	0	NADPH	0,5	NF-kappaB	89,98	NADPH	NF-kappaB	MESH:D009249	4790	Chemical	Gene	NOX5-S|compound|START_ENTITY mediates|nsubj|NOX5-S mediates|dobj|expression expression|nmod|activation activation|nmod|END_ENTITY	NADPH oxidase NOX5-S mediates acid-induced cyclooxygenase-2 expression via activation of NF-kappaB in Barrett 's esophageal_adenocarcinoma cells .
17537988	0	NADPH	65,70	NF-kappaB	8,17	NADPH	NF-kappaB	MESH:D009249	4790	Chemical	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Role of NF-kappaB in transcriptional regulation of the phagocyte NADPH oxidase by tumor_necrosis_factor-alpha .
19542021	0	NADPH	74,79	NF-kappaB	14,23	NADPH	NF-kappaB	MESH:D009249	18033(Tax:10090)	Chemical	Gene	superoxide|amod|START_ENTITY role|nmod|superoxide Activation|dep|role Activation|acl|END_ENTITY	Activation of NF-kappaB by palmitate in endothelial cells : a key role for NADPH oxidase-derived superoxide in response to TLR4 activation .
15491278	0	NADPH	69,74	NOX1	40,44	NADPH	NOX1	MESH:D009249	114243(Tax:10116)	Chemical	Gene	oxidase|compound|START_ENTITY subunit|nmod|oxidase END_ENTITY|appos|subunit	Essential role of ATF-1 in induction of NOX1 , a catalytic subunit of NADPH oxidase : involvement of mitochondrial respiratory chain .
15710429	0	NADPH	131,136	NOX1	102,106	NADPH	NOX1	MESH:D009249	27035	Chemical	Gene	oxidase|compound|START_ENTITY subunit|nmod|oxidase END_ENTITY|appos|subunit	Transactivation of the EGF_receptor and a PI3 kinase-ATF-1 pathway is involved in the upregulation of NOX1 , a catalytic subunit of NADPH oxidase .
15913451	0	NADPH	64,69	NOX1	35,39	NADPH	NOX1	MESH:D009249	114243(Tax:10116)	Chemical	Gene	oxidase|compound|START_ENTITY subunit|nmod|oxidase END_ENTITY|appos|subunit	PKCdelta mediates up-regulation of NOX1 , a catalytic subunit of NADPH oxidase , via transactivation of the EGF receptor : possible involvement of PKCdelta in vascular hypertrophy .
16086438	0	NADPH	44,49	NOX1	14,18	NADPH	NOX1	MESH:D009249	27035	Chemical	Gene	oxidase|compound|START_ENTITY Expression|appos|oxidase Expression|nmod|END_ENTITY	Expression of NOX1 , a superoxide-generating NADPH oxidase , in colon_cancer and inflammatory_bowel_disease .
22403796	0	NADPH	22,27	NOX1	36,40	NADPH	NOX1	MESH:D009249	237038(Tax:10090)	Chemical	Gene	oxidase|compound|START_ENTITY role|nmod|oxidase END_ENTITY|nsubj|role	Potential role of the NADPH oxidase NOX1 in the pathogenesis of 5-fluorouracil-induced intestinal_mucositis in mice .
24051369	0	NADPH	8,13	NOX1	31,35	NADPH	NOX1	MESH:D009249	237038(Tax:10090)	Chemical	Gene	Role|nmod|START_ENTITY END_ENTITY|dep|Role	Role of NADPH oxidase isoforms NOX1 , NOX2 and NOX4 in myocardial_ischemia / reperfusion injury .
24053718	0	NADPH	0,5	NOX1	15,19	NADPH	NOX1	MESH:D009249	237038(Tax:10090)	Chemical	Gene	oxidase|compound|START_ENTITY oxidase|appos|END_ENTITY	NADPH oxidase , NOX1 , mediates vascular_injury in ischemic_retinopathy .
21917939	0	NADPH	65,70	NOX2	60,64	NADPH	NOX2	MESH:D009249	66021(Tax:10116)	Chemical	Gene	deletion|compound|START_ENTITY deletion|compound|END_ENTITY	Neuroprotection from retinal_ischemia / reperfusion injury by NOX2 NADPH oxidase deletion .
16775014	0	NADPH	4,9	NOX4	18,22	NADPH	NOX4	MESH:D009249	50490(Tax:10090)	Chemical	Gene	differentiation|amod|START_ENTITY differentiation|amod|oxidase oxidase|dep|drives drives|nummod|END_ENTITY	The NADPH oxidase NOX4 drives cardiac differentiation : Role in regulating cardiac transcription factors and MAP kinase activation .
17237347	2	NADPH	284,289	NOX4	322,326	NADPH	NOX2	MESH:D009249	1536	Chemical	Gene	oxidase|compound|START_ENTITY subunit|nmod|oxidase homologs|nmod|subunit found|nsubjpass|homologs found|dobj|DUOX1 DUOX1|appos|END_ENTITY	Over the last years , six homologs of the cytochrome subunit of the phagocyte NADPH oxidase were found : NOX1 , NOX3 , NOX4 , NOX5 , DUOX1 , and DUOX2 .
17585072	0	NADPH	46,51	NOX4	68,72	NADPH	NOX4	MESH:D009249	50490(Tax:10090)	Chemical	Gene	regulation|nmod|START_ENTITY oxidase|nsubj|regulation oxidase|dobj|END_ENTITY	Hypoxia-dependent regulation of nonphagocytic NADPH oxidase subunit NOX4 in the pulmonary vasculature .
18554521	0	NADPH	27,32	NOX4	41,45	NADPH	NOX4	MESH:D009249	85431(Tax:10116)	Chemical	Gene	oxidase|compound|START_ENTITY regulation|nmod|oxidase END_ENTITY|nsubj|regulation	Positive regulation of the NADPH oxidase NOX4 promoter in vascular smooth muscle cells by E2F .
19779036	0	NADPH	63,68	NOX4	77,81	NADPH	NOX4	MESH:D009249	50507	Chemical	Gene	expression|nmod|START_ENTITY oxidase|nsubj|expression oxidase|dobj|END_ENTITY	Intracellular expression of reactive oxygen species-generating NADPH oxidase NOX4 in normal and cancer thyroid tissues .
20531308	0	NADPH	4,9	NOX4	19,23	NADPH	NOX4	MESH:D009249	50507	Chemical	Gene	oxidases|nsubj|START_ENTITY oxidases|ccomp|regulate regulate|nsubj|END_ENTITY	The NADPH oxidases NOX4 and DUOX2 regulate cell cycle entry via a p53-dependent pathway .
21071935	0	NADPH	14,19	NOX4	74,78	NADPH	NOX4	MESH:D009249	85431(Tax:10116)	Chemical	Gene	activity|compound|START_ENTITY Regulation|nmod|activity associated|nsubjpass|Regulation associated|nmod|expression expression|compound|END_ENTITY	Regulation of NADPH oxidase activity is associated with miRNA-25-mediated NOX4 expression in experimental diabetic_nephropathy .
21841825	0	NADPH	15,20	NOX4	29,33	NADPH	NOX4	MESH:D009249	50507	Chemical	Gene	oxidase|nsubj|START_ENTITY oxidase|ccomp|mediator mediator|nsubj|END_ENTITY	ROS-generating NADPH oxidase NOX4 is a critical mediator in oncogenic H-Ras-induced DNA damage and subsequent senescence .
22580379	0	NADPH	36,41	NOX4	50,54	NADPH	NOX4	MESH:D009249	50507	Chemical	Gene	role|nmod|START_ENTITY oxidase|nsubj|role oxidase|dobj|END_ENTITY	The emerging role of ROS-generating NADPH oxidase NOX4 in DNA-damage responses .
26054376	0	NADPH	5,10	NOX4	0,4	NADPH	NOX4	MESH:D009249	50490(Tax:10090)	Chemical	Gene	Oxidative|compound|START_ENTITY Oxidative|compound|END_ENTITY	NOX4 NADPH Oxidase-Dependent Mitochondrial Oxidative Stress in Aging-Associated Cardiovascular_Disease .
24371447	0	NADPH	45,50	NOX_2	60,65	NADPH	NOX 2	MESH:D009249	13058(Tax:10090)	Chemical	Gene	oxidase|amod|START_ENTITY oxidase|appos|END_ENTITY	Propofol reduces lipopolysaccharide-induced , NADPH oxidase -LRB- NOX_2 -RRB- mediated TNF - _ a and IL-6 production in macrophages .
15322091	3	NADPH	450,455	Nox1	404,408	NADPH	Nox1	MESH:D009249	27035	Chemical	Gene	oxidase|compound|START_ENTITY subunit|nmod|oxidase END_ENTITY|nmod|subunit	We determined whether a direct interaction of Nox1 and Nox4 with the p22phox subunit of the NADPH oxidase occurs .
16413408	0	NADPH	34,39	Nox1	57,61	NADPH	Nox1	MESH:D009249	27035	Chemical	Gene	isoform|compound|START_ENTITY isoform|appos|END_ENTITY	Transcriptional regulation of the NADPH oxidase isoform , Nox1 , in colon epithelial cells : role of GATA-binding factor -LRB- s -RRB- .
16762923	0	NADPH	85,90	Nox1	99,103	NADPH	Nox1	MESH:D009249	27035	Chemical	Gene	activation|nmod|START_ENTITY Rac|nmod|activation involvement|nmod|Rac oxidase|nsubj|involvement oxidase|dobj|END_ENTITY	Direct involvement of the small GTPase Rac in activation of the superoxide-producing NADPH oxidase Nox1 .
16987012	0	NADPH	0,5	Nox1	66,70	NADPH	Nox1	MESH:D009249	27035	Chemical	Gene	oxidases|amod|START_ENTITY oxidases|dep|role role|nmod|END_ENTITY	NADPH oxidases in the gastrointestinal tract : a potential role of Nox1 in innate immune response and carcinogenesis .
17560373	0	NADPH	35,40	Nox1	30,34	NADPH	Nox1	MESH:D009249	237038(Tax:10090)	Chemical	Gene	oxidase|compound|START_ENTITY oxidase|amod|END_ENTITY	TNF-induced activation of the Nox1 NADPH oxidase and its role in the induction of necrotic cell death .
18446057	0	NADPH	74,79	Nox1	69,73	NADPH	Nox1	MESH:D009249	237038(Tax:10090)	Chemical	Gene	oxidase|compound|START_ENTITY oxidase|compound|END_ENTITY	Prevention of TNF-induced necrotic cell death by rottlerin through a Nox1 NADPH oxidase .
21505267	0	NADPH	91,96	Nox1	62,66	NADPH	Nox1	MESH:D009249	27035	Chemical	Gene	oxidase|compound|START_ENTITY subunit|nmod|oxidase END_ENTITY|appos|subunit	Activation of Src-ATF1 pathway is involved in upregulation of Nox1 , a catalytic subunit of NADPH oxidase , by aldosterone .
22773830	0	NADPH	127,132	Nox1	122,126	NADPH	Nox1	MESH:D009249	27035	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Protein disulfide_isomerase is required for platelet-derived growth factor-induced vascular smooth muscle cell migration , Nox1 NADPH oxidase expression , and RhoGTPase activation .
24365146	0	NADPH	51,56	Nox1	65,69	NADPH	Nox1	MESH:D009249	27035	Chemical	Gene	glycosylation|nmod|START_ENTITY oxidase|nsubj|glycosylation oxidase|dobj|END_ENTITY	N-Linked glycosylation of the superoxide-producing NADPH oxidase Nox1 .
25881746	0	NADPH	15,20	Nox2	30,34	NADPH	Nox2	MESH:D009249	1536	Chemical	Gene	oxidase|amod|START_ENTITY oxidase|appos|END_ENTITY	Phagocyte-like NADPH oxidase -LRB- Nox2 -RRB- promotes activation of p38MAPK in pancreatic b-cells under glucotoxic conditions : Evidence for a requisite role of Ras-related_C3_botulinum_toxin_substrate_1 -LRB- Rac1 -RRB- .
15927447	0	NADPH	77,82	Nox4	23,27	NADPH	Nox4	MESH:D009249	50507	Chemical	Gene	oxidases|compound|START_ENTITY reveals|advcl|oxidases reveals|nsubj|analysis analysis|nmod|END_ENTITY	Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases .
18508317	0	NADPH	23,28	Nox4	37,41	NADPH	Nox4	MESH:D009249	50507	Chemical	Gene	expression|nmod|START_ENTITY oxidase|nsubj|expression oxidase|dobj|END_ENTITY	Enhanced expression of NADPH oxidase Nox4 in human gliomas and its roles in cell proliferation and survival .
19056645	0	NADPH	76,81	Nox4	71,75	NADPH	Nox4	MESH:D009249	85431(Tax:10116)	Chemical	Gene	oxidase|compound|START_ENTITY oxidase|compound|END_ENTITY	Green_tea -LRB- Camellia sinensis -RRB- attenuates nephropathy by downregulating Nox4 NADPH oxidase in diabetic spontaneously hypertensive rats .
19118162	0	NADPH	5,10	Nox4	0,4	NADPH	Nox4	MESH:D009249	100523323	Chemical	Gene	mediates|compound|START_ENTITY mediates|compound|END_ENTITY	Nox4 NADPH oxidase mediates oxidative stress and apoptosis caused by TNF-alpha in cerebral vascular endothelial cells .
20083859	0	NADPH	153,158	Nox4	176,180	NADPH	Nox4	MESH:D009249	50507	Chemical	Gene	subunit|amod|START_ENTITY subunit|appos|END_ENTITY	Resveratrol reduces endothelial oxidative stress by modulating the gene expression of superoxide_dismutase 1 -LRB- SOD1 -RRB- , glutathione_peroxidase_1 -LRB- GPx1 -RRB- and NADPH oxidase subunit -LRB- Nox4 -RRB- .
20622120	0	NADPH	121,126	Nox4	38,42	NADPH	Nox4	MESH:D009249	50507	Chemical	Gene	oxidases|compound|START_ENTITY source|nsubj|oxidases kappa|acl:relcl|source smooth|dobj|kappa smooth|nsubj|expression expression|amod|END_ENTITY	PPAR -LCB- gamma -RCB- regulates hypoxia-induced Nox4 expression in human pulmonary artery smooth muscle cells through NF - -LCB- kappa -RCB- B. NADPH oxidases are a major source of superoxide production in the vasculature .
21123734	0	NADPH	5,10	Nox4	0,4	NADPH	Nox4	MESH:D009249	50507	Chemical	Gene	species|compound|START_ENTITY species|compound|END_ENTITY	Nox4 NADPH oxidase-derived reactive oxygen species , via endogenous carbon_monoxide , promote survival of brain endothelial cells during TNF-a-induced apoptosis .
21212466	0	NADPH	4,9	Nox4	18,22	NADPH	Nox4	MESH:D009249	50507	Chemical	Gene	oxidase|nsubj|START_ENTITY oxidase|dobj|END_ENTITY	The NADPH oxidase Nox4 and aging in the heart .
21415386	0	NADPH	17,22	Nox4	12,16	NADPH	Nox4	MESH:D009249	50490(Tax:10090)	Chemical	Gene	oxidase|compound|START_ENTITY oxidase|compound|END_ENTITY	Endothelial Nox4 NADPH oxidase enhances vasodilatation and reduces blood pressure in vivo .
22456182	0	NADPH	65,70	Nox4	0,4	NADPH	Nox4	MESH:D009249	50490(Tax:10090)	Chemical	Gene	oxidase|nsubj|START_ENTITY generating|xcomp|oxidase species|acl|generating species|nsubj|END_ENTITY	Nox4 is a protective reactive oxygen species generating vascular NADPH oxidase .
23329835	0	NADPH	121,126	Nox4	136,140	NADPH	Nox4	MESH:D009249	50490(Tax:10090)	Chemical	Gene	oxidase|compound|START_ENTITY oxidase|appos|END_ENTITY	Thioredoxin-interacting_protein mediates high glucose-induced reactive oxygen species generation by mitochondria and the NADPH oxidase , Nox4 , in mesangial cells .
23840483	0	NADPH	104,109	Nox4	99,103	NADPH	Nox4	MESH:D009249	50507	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Heme_oxygenase-1 regulates matrix metalloproteinase MMP-1 secretion and chondrocyte cell death via Nox4 NADPH oxidase activity in chondrocytes .
26429798	0	NADPH	5,10	Nox4	0,4	NADPH	Nox4	MESH:D009249	50507	Chemical	Gene	oxidase|compound|START_ENTITY oxidase|compound|END_ENTITY	Nox4 NADPH oxidase : emerging from the veil of darkness .
26861875	0	NADPH	50,55	Nox4	64,68	NADPH	Nox4	MESH:D009249	50490(Tax:10090)	Chemical	Gene	oxidase|advmod|START_ENTITY protein|amod|oxidase protein|compound|END_ENTITY	The endoplasmic reticulum chaperone calnexin is a NADPH oxidase Nox4 interacting protein .
13130177	0	NADPH	21,26	P22PHOX	35,42	NADPH	P22PHOX	MESH:D009249	1535	Chemical	Gene	oxidase|compound|START_ENTITY Polymorphisms|nmod|oxidase END_ENTITY|nsubj|Polymorphisms	Polymorphisms of the NADPH oxidase P22PHOX gene in a Caucasian population with intracranial_aneurysms .
19664386	0	NADPH	120,125	PAI-1	54,59	NADPH	PAI-1	MESH:D009249	5054	Chemical	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	-LSB- Advanced glycation end products induce expression of PAI-1 in cultured human proximal tubular epithelial cells through NADPH oxidase dependent pathway -RSB- .
23774252	0	NADPH	0,5	PYK2	28,32	NADPH	PYK2	MESH:D009249	50646(Tax:10116)	Chemical	Gene	activation|nummod|START_ENTITY activation|compound|END_ENTITY	NADPH oxidase/ROS-dependent PYK2 activation is involved in TNF-a-induced matrix_metalloproteinase-9 expression in rat heart-derived H9c2 cells .
10727429	0	NADPH	37,42	Protein_kinase_C-beta	0,21	NADPH	Protein kinase C-beta	MESH:D009249	5579	Chemical	Gene	contributes|xcomp|START_ENTITY contributes|nsubj|END_ENTITY	Protein_kinase_C-beta contributes to NADPH oxidase activation in neutrophils .
21900546	0	NADPH	0,5	RAC2	130,134	NADPH	RAC2	MESH:D009249	5880	Chemical	Gene	complex|amod|START_ENTITY complex|dep|identification identification|acl:relcl|results results|nmod|reduced reduced|nmod|END_ENTITY	NADPH oxidase complex and IBD candidate gene studies : identification of a rare variant in NCF2 that results in reduced binding to RAC2 .
12912997	0	NADPH	43,48	Rac1	20,24	NADPH	Rac1	MESH:D009249	5879	Chemical	Gene	complex|compound|START_ENTITY END_ENTITY|nmod|complex	Human monocytes use Rac1 , not Rac2 , in the NADPH oxidase complex .
20943855	0	NADPH	15,20	Rac1	131,135	NADPH	Rac1	MESH:D009249	5879	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Phagocyte-like NADPH oxidase promotes cytokine-induced mitochondrial_dysfunction in pancreatic b-cells : evidence for regulation by Rac1 .
11224519	0	NADPH	49,54	Rac2	20,24	NADPH	Rac2	MESH:D009249	5880	Chemical	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Molecular basis for Rac2 regulation of phagocyte NADPH oxidase .
12912997	0	NADPH	43,48	Rac2	30,34	NADPH	Rac2	MESH:D009249	5880	Chemical	Gene	complex|compound|START_ENTITY Rac1|nmod|complex Rac1|appos|END_ENTITY	Human monocytes use Rac1 , not Rac2 , in the NADPH oxidase complex .
8282094	3	NADPH	416,421	Rac2	353,357	NADPH	Rac2	MESH:D009249	5880	Chemical	Gene	oxidase|compound|START_ENTITY component|nmod|oxidase forms|dobj|component forms|nsubj|END_ENTITY	Rac2 forms a third cytosolic component of the human neutrophil NADPH oxidase .
9642115	0	NADPH	10,15	Rac2	97,101	NADPH	Rac2	MESH:D009249	5880	Chemical	Gene	possesses|nsubj|START_ENTITY possesses|dobj|site site|nmod|END_ENTITY	Phagocyte NADPH oxidase p67-phox possesses a novel carboxylterminal binding site for the GTPases Rac2 and Cdc42 .
23422569	0	NADPH	15,20	SIRT1	0,5	NADPH	SIRT1	MESH:D009249	309757(Tax:10116)	Chemical	Gene	activation|amod|START_ENTITY inhibits|dobj|activation inhibits|nsubj|END_ENTITY	SIRT1 inhibits NADPH oxidase activation and protects endothelial function in the rat aorta : implications for vascular aging .
24895121	0	NADPH	40,45	Siglec-E	0,8	NADPH	Siglec-E	MESH:D009249	83382(Tax:10090)	Chemical	Gene	activation|compound|START_ENTITY promotes|dobj|activation promotes|nsubj|END_ENTITY	Siglec-E promotes b2-integrin-dependent NADPH oxidase activation to suppress neutrophil recruitment to the lung .
10843714	0	NADPH	113,118	VCAM-1	75,81	NADPH	VCAM-1	MESH:D009249	22329(Tax:10090)	Chemical	Gene	signaling|nmod|START_ENTITY signaling|compound|END_ENTITY	Lymphocyte migration through monolayers of endothelial cell lines involves VCAM-1 signaling via endothelial cell NADPH oxidase .
11641265	0	NADPH	126,131	Vascular_endothelial_growth_factor	0,34	NADPH	Vascular endothelial growth factor	MESH:D009249	7422	Chemical	Gene	mechanism|compound|START_ENTITY induces|nmod|mechanism induces|nsubj|END_ENTITY	Vascular_endothelial_growth_factor induces manganese-superoxide_dismutase expression in endothelial cells by a Rac1-regulated NADPH oxidase-dependent mechanism .
23931758	0	NADPH	88,93	Yno1p	103,108	NADPH	Yno1p	MESH:D009249	852716(Tax:4932)	Chemical	Gene	oxidase|compound|START_ENTITY oxidase|appos|END_ENTITY	Loss of cytochrome c oxidase promotes RAS-dependent ROS production from the ER resident NADPH oxidase , Yno1p , in yeast .
15123520	0	NADPH	57,62	angiotensin-converting_enzyme	134,163	NADPH	angiotensin-converting enzyme	MESH:D009249	11421(Tax:10090)	Chemical	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Aldosterone administration to mice stimulates macrophage NADPH oxidase and increases atherosclerosis development : a possible role for angiotensin-converting_enzyme and the receptors for angiotensin II and aldosterone .
23940049	0	NADPH	5,10	angiotensin_II	142,156	NADPH	angiotensin II	MESH:D009249	183	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Nox4 NADPH oxidase mediates peroxynitrite-dependent uncoupling of endothelial_nitric-oxide_synthase and fibronectin expression in response to angiotensin_II : role of mitochondrial reactive oxygen species .
25272943	0	NADPH	121,126	angiotensin_II	91,105	NADPH	angiotensin II	MESH:D009249	183	Chemical	Gene	pathway|compound|START_ENTITY END_ENTITY|nmod|pathway	Inhibitory effect of reinioside_C on vascular smooth muscle cells proliferation induced by angiotensin_II via inhibiting NADPH oxidase-ROS-ENK1 / 2-NF-kappaB-AP-1 pathway .
18397177	0	NADPH	10,15	c-Src	34,39	NADPH	c-Src	MESH:D009249	6714	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|amod|END_ENTITY	Endosomal NADPH oxidase regulates c-Src activation following hypoxia/reoxygenation injury .
12101222	0	NADPH	64,69	cPLA2	28,33	NADPH	cPLA2	MESH:D009249	5321	Chemical	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Cytosolic_phospholipase_A2 -LRB- cPLA2 -RRB- regulation of human monocyte NADPH oxidase activity .
24296130	0	NADPH	48,53	cyclooxygenase-2	16,32	NADPH	cyclooxygenase-2	MESH:D009249	19225(Tax:10090)	Chemical	Gene	AP-1|compound|START_ENTITY expression|nmod|AP-1 expression|amod|END_ENTITY	Genipin induces cyclooxygenase-2 expression via NADPH oxidase , MAPKs , AP-1 , and NF-kB in RAW 264.7 cells .
15577240	0	NADPH	111,116	cytochrome_P450	95,110	NADPH	cytochrome P450	MESH:D009249	25251(Tax:10116)	Chemical	Gene	system|compound|START_ENTITY system|amod|END_ENTITY	Synthesis and in vitro antioxidant activity of glycyrrhetinic_acid derivatives tested with the cytochrome_P450 / NADPH system .
7696534	0	NADPH	67,72	cytochrome_P450	48,63	NADPH	cytochrome P450	MESH:D009249	25251(Tax:10116)	Chemical	Gene	oxidation|amod|START_ENTITY END_ENTITY|nmod|oxidation	Hepatic biotransformation of parathion : role of cytochrome_P450 in NADPH - and NADH-mediated microsomal oxidation in vitro .
24530354	0	NADPH	129,134	cytochrome_P450_1A1	99,118	NADPH	cytochrome P450 1A1	MESH:D009249	13076(Tax:10090)	Chemical	Gene	catalyzed|nmod|START_ENTITY catalyzed|nmod|END_ENTITY	Cytochrome_b5 and epoxide hydrolase contribute to benzo -LSB- a -RSB- pyrene-DNA adduct formation catalyzed by cytochrome_P450_1A1 under low NADPH : P450_oxidoreductase conditions .
25038863	0	NADPH	37,42	cytochrome_P450_reductase	43,68	NADPH	cytochrome P450 reductase	MESH:D009249	5447	Chemical	Gene	gene|compound|START_ENTITY gene|nummod|END_ENTITY	Molecular population genetics of the NADPH cytochrome_P450_reductase -LRB- CPR -RRB- gene in Anopheles minimus .
12913107	0	NADPH	83,88	cytosolic_phospholipase_A2	20,46	NADPH	cytosolic phospholipase A2	MESH:D009249	5321	Chemical	Gene	oxidase|compound|START_ENTITY mediated|nmod|oxidase mediated|nsubj|targeting targeting|nmod|END_ENTITY	Unique targeting of cytosolic_phospholipase_A2 to plasma membranes mediated by the NADPH oxidase in phagocytes .
19280714	0	NADPH	74,79	cytosolic_phospholipase_A2	32,58	NADPH	cytosolic phospholipase A2	MESH:D009249	5321	Chemical	Gene	AP-1|compound|START_ENTITY expression|nmod|AP-1 expression|amod|END_ENTITY	Cigarette smoke extract induces cytosolic_phospholipase_A2 expression via NADPH oxidase , MAPKs , AP-1 , and NF-kappaB in human tracheal smooth muscle cells .
22231145	0	NADPH	107,112	cytosolic_phospholipase_A2	51,77	NADPH	cytosolic phospholipase A2	MESH:D009249	18783(Tax:10090)	Chemical	Gene	species/activator|compound|START_ENTITY decrease|nmod|species/activator expression|nmod|decrease expression|amod|END_ENTITY	Heme_oxygenase_1 attenuates interleukin-1b-induced cytosolic_phospholipase_A2 expression via a decrease in NADPH oxidase/reactive oxygen species/activator _ protein_1 activation in rheumatoid_arthritis synovial fibroblasts .
24616552	0	NADPH	121,126	cytosolic_phospholipase_A2	50,76	NADPH	cytosolic phospholipase A2	MESH:D009249	5321	Chemical	Gene	oxidase/ROS|compound|START_ENTITY inhibition|nmod|oxidase/ROS expression|nmod|inhibition expression|amod|END_ENTITY	HO-1 induction by CO-RM2 attenuates TNF-a-induced cytosolic_phospholipase_A2 expression via inhibition of PKCa-dependent NADPH oxidase/ROS and NF-kB .
9417101	0	NADPH	84,89	cytosolic_phospholipase_A2	25,51	NADPH	cytosolic phospholipase A2	MESH:D009249	5321	Chemical	Gene	oxidase|compound|START_ENTITY requirement|nmod|oxidase requirement|nmod|END_ENTITY	Essential requirement of cytosolic_phospholipase_A2 for activation of the phagocyte NADPH oxidase .
11432850	0	NADPH	73,78	diaphorase	98,108	NADPH	diaphorase	MESH:D009249	1738	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Essential requirement of cytosolic_phospholipase_A -LRB- 2 -RRB- for stimulation of NADPH oxidase-associated diaphorase activity in granulocyte-like cells .
16331104	0	NADPH	24,29	eNOS	49,53	NADPH	eNOS	MESH:D009249	24600(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|activity activity|compound|END_ENTITY	Quercetin downregulates NADPH oxidase , increases eNOS activity and prevents endothelial_dysfunction in spontaneously hypertensive rats .
16891913	0	NADPH	108,113	eNOS	72,76	NADPH	eNOS	MESH:D009249	18127(Tax:10090)	Chemical	Gene	pathway|compound|START_ENTITY END_ENTITY|nmod|pathway	Ramipril treatment protects against nitrate-induced oxidative stress in eNOS - / - mice : An implication of the NADPH oxidase pathway .
23183177	0	NADPH	86,91	glucose-6-phosphate_dehydrogenase	105,138	NADPH	glucose-6-phosphate dehydrogenase	MESH:D009249	2539	Chemical	Gene	START_ENTITY|acl|generated generated|advcl|END_ENTITY	The microsomal enzyme 17b-hydroxysteroid dehydrogenase 3 faces the cytoplasm and uses NADPH generated by glucose-6-phosphate_dehydrogenase .
10393927	0	NADPH	65,70	gp91	44,48	NADPH	gp91	MESH:D009249	18733(Tax:10090)	Chemical	Gene	oxidase|compound|START_ENTITY subunit|nmod|oxidase subunit|amod|END_ENTITY	O2 sensing is preserved in mice lacking the gp91 phox subunit of NADPH oxidase .
11457979	0	NADPH	60,65	gp91	49,53	NADPH	gp91	MESH:D009249	543571(Tax:4081)	Chemical	Gene	oxidase|compound|START_ENTITY oxidase|amod|END_ENTITY	Superoxide production by plant homologues of the gp91 -LRB- phox -RRB- NADPH oxidase .
8400270	0	NADPH	54,59	gp91-phox	112,121	NADPH	gp91-phox	MESH:D009249	1536	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	X-linked_chronic_granulomatous_disease : correction of NADPH oxidase defect by retrovirus-mediated expression of gp91-phox .
10884368	0	NADPH	22,27	gp91phox	2,10	NADPH	gp91phox	MESH:D009249	13058(Tax:10090)	Chemical	Gene	oxidase|compound|START_ENTITY oxidase|amod|END_ENTITY	A gp91phox containing NADPH oxidase selectively expressed in endothelial cells is a major source of oxygen radical generation in the arterial wall .
11200061	0	NADPH	43,48	gp91phox	34,42	NADPH	gp91phox	MESH:D009249	1536	Chemical	Gene	oxidase|compound|START_ENTITY oxidase|amod|END_ENTITY	Transcriptional activation of the gp91phox NADPH oxidase subunit by TPA in HL-60 cells .
12804147	0	NADPH	39,44	gp91phox	149,157	NADPH	gp91phox	MESH:D009249	13058(Tax:10090)	Chemical	Gene	reconstitution|nmod|START_ENTITY oxidase|nsubj|reconstitution oxidase|nmod|X-linked_chronic_granulomatous_disease X-linked_chronic_granulomatous_disease|acl|using using|dobj|vector vector|acl|expressing expressing|dobj|END_ENTITY	Long-term high-level reconstitution of NADPH oxidase activity in murine X-linked_chronic_granulomatous_disease using a bicistronic vector expressing gp91phox and a Delta LNGFR cell surface marker .
15070892	0	NADPH	88,93	gp91phox	103,111	NADPH	gp91phox	MESH:D009249	13058(Tax:10090)	Chemical	Gene	oxidase|amod|START_ENTITY oxidase|appos|END_ENTITY	Reoxygenation-induced constriction in murine coronary arteries : the role of endothelial NADPH oxidase -LRB- gp91phox -RRB- and intracellular superoxide .
15102091	0	NADPH	15,20	gp91phox	52,60	NADPH	gp91phox	MESH:D009249	1536	Chemical	Gene	system|compound|START_ENTITY system|acl|containing containing|dobj|homologs homologs|amod|END_ENTITY	A constitutive NADPH oxidase-like system containing gp91phox homologs in human keratinocytes .
16407283	0	NADPH	31,36	gp91phox	75,83	NADPH	gp91phox	MESH:D009249	13058(Tax:10090)	Chemical	Gene	oxidase|nsubj|START_ENTITY oxidase|advcl|inducing inducing|dobj|expression expression|nmod|END_ENTITY	NF-kappaB regulates phagocytic NADPH oxidase by inducing the expression of gp91phox .
16505175	0	NADPH	126,131	gp91phox	105,113	NADPH	gp91phox	MESH:D009249	66021(Tax:10116)	Chemical	Gene	oxidase|amod|START_ENTITY containing|dobj|oxidase containing|nsubj|myocytes myocytes|dep|involvement involvement|nmod|Nox2 Nox2|appos|END_ENTITY	Glycated proteins stimulate reactive oxygen species production in cardiac myocytes : involvement of Nox2 -LRB- gp91phox -RRB- - containing NADPH oxidase .
17538186	0	NADPH	29,34	gp91phox	8,16	NADPH	gp91phox	MESH:D009249	13058(Tax:10090)	Chemical	Gene	Role|dep|START_ENTITY Role|nmod|END_ENTITY	Role of gp91phox - containing NADPH oxidase in mediating the effect of K restriction on ROMK channels and renal K excretion .
22094225	0	NADPH	29,34	gp91phox	78,86	NADPH	gp91phox	MESH:D009249	1536	Chemical	Gene	oxidase|amod|START_ENTITY activates|dobj|oxidase activates|nmod|END_ENTITY	Rotenone activates phagocyte NADPH oxidase by binding to its membrane subunit gp91phox .
9032440	0	NADPH	72,77	gp91phox	35,43	NADPH	gp91phox	MESH:D009249	1536	Chemical	Gene	oxidase|compound|START_ENTITY flavocytochrome|nmod|oxidase END_ENTITY|appos|flavocytochrome	Analysis of glycosylation sites on gp91phox , the flavocytochrome of the NADPH oxidase , by site-directed mutagenesis and translation in vitro .
9445369	0	NADPH	0,5	gp91phox	57,65	NADPH	gp91phox	MESH:D009249	1536	Chemical	Gene	oxidase|compound|START_ENTITY contains|nsubj|oxidase contains|dobj|isoform isoform|nmod|subunit subunit|amod|END_ENTITY	NADPH oxidase of chondrocytes contains an isoform of the gp91phox subunit .
9490748	0	NADPH	34,39	gp91phox	48,56	NADPH	gp91phox	MESH:D009249	1536	Chemical	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	A plant homolog of the neutrophil NADPH oxidase gp91phox subunit gene encodes a plasma membrane protein with Ca2 + binding motifs .
17679649	0	NADPH	49,54	heme_oxygenase-1	13,29	NADPH	heme oxygenase-1	MESH:D009249	3162	Chemical	Gene	oxidase|compound|START_ENTITY oxidase|amod|END_ENTITY	Induction of heme_oxygenase-1 in vivo suppresses NADPH oxidase derived oxidative stress .
18178668	0	NADPH	81,86	inducible_nitric-oxide_synthase	133,164	NADPH	inducible nitric-oxide synthase	MESH:D009249	4843	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|nmod|END_ENTITY	BYK191023 -LRB- 2 - -LSB- 2 - -LRB- 4-methoxy-pyridin-2-yl -RRB- - ethyl -RSB- -3 h-imidazo -LSB- 4,5-b -RSB- pyridine -RRB- is an NADPH - and time-dependent irreversible inhibitor of inducible_nitric-oxide_synthase .
7578267	0	NADPH	60,65	interferon-gamma	23,39	NADPH	interferon-gamma	MESH:D009249	3458	Chemical	Gene	induction|nmod|START_ENTITY END_ENTITY|nmod|induction	Cooperative effects of interferon-gamma on the induction of NADPH oxidase by retinoic_acid or 1,25 -LRB- OH -RRB- 2-vitamin_D3 in monocytic U937 cells .
15013818	0	NADPH	0,5	microsomal_glutathione_transferase_1	30,66	NADPH	microsomal glutathione transferase 1	MESH:D009249	4257	Chemical	Gene	START_ENTITY|dobj|activation activation|nmod|END_ENTITY	NADPH dependent activation of microsomal_glutathione_transferase_1 .
11993849	0	NADPH	37,42	nitric_oxide_synthase-1	67,90	NADPH	nitric oxide synthase-1	MESH:D009249	18125(Tax:10090)	Chemical	Gene	reaction|compound|START_ENTITY reaction|nmod|END_ENTITY	The specificity of the histochemical NADPH diaphorase reaction for nitric_oxide_synthase-1 in skeletal muscles is increased in the presence of urea .
18287880	0	NADPH	87,92	nox1	17,21	NADPH	nox1	MESH:D009249	27035	Chemical	Gene	unstimulated|nmod|START_ENTITY END_ENTITY|nmod|unstimulated	Distinct role of nox1 , nox2 , and p47phox in unstimulated versus angiotensin_II-induced NADPH oxidase activity in human venous smooth muscle cells .
19834108	0	NADPH	57,62	nox1	37,41	NADPH	nox1	MESH:D009249	27035	Chemical	Gene	oxidase|compound|START_ENTITY oxidase|amod|END_ENTITY	Jak/STAT signaling pathway regulates nox1 and nox4-based NADPH oxidase in human aortic smooth muscle cells .
10848984	0	NADPH	8,13	oxidoreductase	22,36	NADPH	oxidoreductase	MESH:D009249	827783(Tax:3702)	Chemical	Gene	START_ENTITY|dep|activity activity|compound|END_ENTITY	A novel NADPH : diamide oxidoreductase activity in arabidopsis_thaliana P1 zeta-crystallin .
20470696	0	NADPH	53,58	p22	33,36	NADPH	p22	MESH:D009249	11261	Chemical	Gene	oxidase|compound|START_ENTITY subunit|nmod|oxidase subunit|amod|END_ENTITY	-LSB- Evaluation of the expression of p22 phox subunit of NADPH oxidase -LRB- NOX -RRB- in prostate_cancer and benign_prostatic_hyperplasia : a comparative study -RSB- .
22932942	0	NADPH	45,50	p22	59,62	NADPH	p22	MESH:D009249	11261	Chemical	Gene	polymorphism|nmod|START_ENTITY Association|nmod|polymorphism oxidase|nsubj|Association oxidase|dobj|gene gene|amod|END_ENTITY	Association of the C242T polymorphism in the NADPH oxidase p22 phox gene with carotid_atherosclerosis in Slovenian patients with type 2 diabetes .
19102345	0	NADPH	69,74	p22PHOX	48,55	NADPH	p22PHOX	MESH:D009249	1535	Chemical	Gene	component|nmod|START_ENTITY component|amod|END_ENTITY	No association between a genetic variant of the p22PHOX component of NADPH oxidase C242T and ulcerative_colitis .
19260521	0	NADPH	44,49	p22PHOX	23,30	NADPH	p22PHOX	MESH:D009249	1535	Chemical	Gene	C242T|compound|START_ENTITY component|nmod|C242T component|amod|END_ENTITY	Genetic variant of the p22PHOX component of NADPH oxidase C242T and the incidence of gastric_cancer in Japan .
24573492	0	NADPH	26,31	p22PHOX	40,47	NADPH	p22PHOX	MESH:D009249	1535	Chemical	Gene	polymorphism|nmod|START_ENTITY oxidase|nsubj|polymorphism oxidase|dobj|gene gene|amod|END_ENTITY	C242T polymorphism of the NADPH oxidase p22PHOX gene and its association with endothelial_dysfunction in asymptomatic individuals with essential_systemic_hypertension .
10754002	0	NADPH	22,27	p22_PHOX	36,44	NADPH	p22 PHOX	MESH:D009249	1535	Chemical	Gene	polymorphism|nmod|START_ENTITY oxidase|nsubj|polymorphism oxidase|dobj|gene gene|amod|END_ENTITY	C242T polymorphism of NADPH oxidase p22_PHOX gene and ischemic_cerebrovascular_disease in the Japanese population .
15585859	0	NADPH	28,33	p22phox	148,155	NADPH	p22phox	MESH:D009249	1535	Chemical	Gene	inhibitors|nmod|START_ENTITY oxidase|nsubj|inhibitors oxidase|nmod|subunit subunit|amod|END_ENTITY	Site-specific inhibitors of NADPH oxidase activity and structural probes of flavocytochrome b : characterization of six monoclonal antibodies to the p22phox subunit .
15851618	0	NADPH	99,104	p22phox	80,87	NADPH	p22phox	MESH:D009249	79129(Tax:10116)	Chemical	Gene	oxidase|compound|START_ENTITY subunit|nmod|oxidase subunit|amod|END_ENTITY	Hyperhomocysteinemia , a cardiac_metabolic_disease : role of nitric_oxide and the p22phox subunit of NADPH oxidase .
16759310	0	NADPH	32,37	p22phox	47,54	NADPH	p22phox	MESH:D009249	1535	Chemical	Gene	oxidase|advmod|START_ENTITY oxidase|dep|END_ENTITY	Differential gene expression of NADPH oxidase -LRB- p22phox -RRB- and hemoxygenase-1 in patients with Type 2 diabetes and microangiopathy .
17085464	0	NADPH	0,5	p22phox	31,38	NADPH	p22phox	MESH:D009249	79129(Tax:10116)	Chemical	Gene	oxidase|nsubj|START_ENTITY oxidase|dobj|subunits subunits|appos|Rac-1 Rac-1|dep|END_ENTITY	NADPH oxidase subunits -LRB- NOX-1 , p22phox , Rac-1 -RRB- and tacrolimus-induced nephrotoxicity in a rat renal transplant model .
18309110	0	NADPH	45,50	p22phox	104,111	NADPH	p22phox	MESH:D009249	1535	Chemical	Gene	oxidase|compound|START_ENTITY regulation|nmod|oxidase regulation|dep|role role|nmod|subunit subunit|amod|END_ENTITY	AP-1-dependent transcriptional regulation of NADPH oxidase in human aortic smooth muscle cells : role of p22phox subunit .
18672803	0	NADPH	81,86	p22phox	62,69	NADPH	p22phox	MESH:D009249	1535	Chemical	Gene	oxidase|compound|START_ENTITY subunit|nmod|oxidase subunit|amod|END_ENTITY	-LSB- Association of C242T and A640G polymorphisms in the gene for p22phox subunit of NADPH oxidase with the risk of bronchial_asthma : a pilot study -RSB- .
19516159	0	NADPH	19,24	p22phox	33,40	NADPH	p22phox	MESH:D009249	1535	Chemical	Gene	polymorphisms|amod|START_ENTITY polymorphisms|amod|END_ENTITY	Exercise training , NADPH oxidase p22phox gene polymorphisms , and hypertension .
21118808	0	NADPH	0,5	p22phox	103,110	NADPH	p22phox	MESH:D009249	1535	Chemical	Gene	activation|amod|START_ENTITY mediated|nsubjpass|activation mediated|nmod|up-regulation up-regulation|nmod|END_ENTITY	NADPH oxidase activation in pancreatic_cancer cells is mediated through Akt-dependent up-regulation of p22phox .
21795992	0	NADPH	107,112	p22phox	99,106	NADPH	p22phox	MESH:D009249	79129(Tax:10116)	Chemical	Gene	oxidase|amod|START_ENTITY oxidase|amod|END_ENTITY	Administration of rosmarinic_acid reduces cardiopathology and blood pressure through inhibition of p22phox NADPH oxidase in fructose-fed hypertensive rats .
21872458	0	NADPH	0,5	p22phox	14,21	NADPH	p22phox	MESH:D009249	1535	Chemical	Gene	oxidase|nsubj|START_ENTITY oxidase|dobj|polymorphisms polymorphisms|amod|END_ENTITY	NADPH oxidase p22phox polymorphisms and oxidative stress in patients with obstructive_sleep_apnoea .
23755540	0	NADPH	46,51	p22phox	60,67	NADPH	p22phox	MESH:D009249	1535	Chemical	Gene	polymorphism|nmod|START_ENTITY Association|nmod|polymorphism oxidase|nsubj|Association oxidase|dobj|gene gene|amod|END_ENTITY	-LSB- Association between 242C _ > _ T polymorphism of NADPH oxidase p22phox gene -LRB- CYBA -RRB- and longevity in Russian population -RSB- .
24035466	0	NADPH	53,58	p22phox	77,84	NADPH	p22phox	MESH:D009249	1535	Chemical	Gene	deficiency|nmod|START_ENTITY due|nmod|deficiency activation|amod|due oxidase|nsubj|activation oxidase|dobj|END_ENTITY	Altered vascular activation due to deficiency of the NADPH oxidase component p22phox .
24415302	0	NADPH	22,27	p22phox	36,43	NADPH	p22phox	MESH:D009249	1535	Chemical	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	C242T polymorphism of NADPH oxidase p22phox gene reduces the risk of coronary_artery_disease in a random sample of Egyptian population .
25599773	0	NADPH	0,5	p22phox	14,21	NADPH	p22phox	MESH:D009249	1535	Chemical	Gene	oxidase|nsubj|START_ENTITY oxidase|dobj|expression expression|amod|END_ENTITY	NADPH oxidase p22phox gene expression in ulcerative_colitis .
8703027	1	NADPH	175,180	p22phox	133,140	NADPH	p22phox	MESH:D009249	1535	Chemical	Gene	oxidase|compound|START_ENTITY activation|nmod|oxidase required|nmod|activation required|nsubjpass|interaction interaction|nmod|domain domain|nmod|p47phox p47phox|nmod|END_ENTITY	Specific interaction of the N-terminal Src homology 3 domain of p47phox with p22phox is required for activation of the NADPH oxidase .
16102984	0	NADPH	18,23	p40phox	0,7	NADPH	p40phox	MESH:D009249	4689	Chemical	Gene	subunit|compound|START_ENTITY END_ENTITY|dep|subunit	p40phox : the last NADPH oxidase subunit .
11716484	0	NADPH	4,9	p47	29,32	NADPH	p47	MESH:D009249	5341	Chemical	Gene	oxidase|nsubj|START_ENTITY oxidase|dobj|END_ENTITY	The NADPH oxidase components p47 -LRB- phox -RRB- and p40 -LRB- phox -RRB- bind to moesin through their PX domain .
15147273	0	NADPH	119,124	p47phox	70,77	NADPH	p47phox	MESH:D009249	653361	Chemical	Gene	oxidase|compound|START_ENTITY subunit|nmod|oxidase END_ENTITY|appos|subunit	A molecular mechanism for autoinhibition of the tandem SH3 domains of p47phox , the regulatory subunit of the phagocyte NADPH oxidase .
17157199	0	NADPH	19,24	p47phox	41,48	NADPH	p47phox	MESH:D009249	17969(Tax:10090)	Chemical	Gene	oxidase|nsubj|START_ENTITY oxidase|dobj|expression expression|amod|END_ENTITY	Ascorbate inhibits NADPH oxidase subunit p47phox expression in microvascular endothelial cells .
10231525	0	NADPH	78,83	p67PHOX	32,39	NADPH	p67PHOX	MESH:D009249	4688	Chemical	Gene	oxidase|compound|START_ENTITY subunit|nmod|oxidase END_ENTITY|appos|subunit	NADPH dehydrogenase activity of p67PHOX , a cytosolic subunit of the leukocyte NADPH oxidase .
16077929	0	NADPH	42,47	p67phox	23,30	NADPH	p67phox	MESH:D009249	4688	Chemical	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	Increased level of the p67phox subunit of NADPH oxidase by 4HPR in head and neck squamous_carcinoma cells .
17060455	0	NADPH	45,50	p67phox	17,24	NADPH	p67phox	MESH:D009249	4688	Chemical	Gene	oxidase|nsubj|START_ENTITY regulates|xcomp|oxidase regulates|nsubj|END_ENTITY	The Rac effector p67phox regulates phagocyte NADPH oxidase by stimulating Vav1 guanine_nucleotide exchange activity .
25633958	0	NADPH	35,40	phospholipase_A2	112,128	NADPH	phospholipase A2	MESH:D009249	151056	Chemical	Gene	START_ENTITY|nmod|cells cells|nmod|END_ENTITY	Organochlorine insecticides induce NADPH oxidase-dependent reactive oxygen species in human monocytic cells via phospholipase_A2 / arachidonic_acid .
20712533	0	NADPH	5,10	transient_receptor_potential_vanilloid_1	27,67	NADPH	transient receptor potential vanilloid 1	MESH:D009249	83810(Tax:10116)	Chemical	Gene	oxidase|nsubj|START_ENTITY oxidase|dobj|END_ENTITY	NOX3 NADPH oxidase couples transient_receptor_potential_vanilloid_1 to signal_transducer_and_activator_of_transcription_1-mediated inflammation and hearing_loss .
15743827	0	NADPH	48,53	tumor_necrosis_factor_alpha	6,33	NADPH	tumor necrosis factor alpha	MESH:D009249	7124	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Acute tumor_necrosis_factor_alpha signaling via NADPH oxidase in microvascular endothelial cells : role of p47phox phosphorylation and binding to TRAF4 .
16949073	0	NADPH	81,86	vascular_endothelial_growth_factor	16,50	NADPH	vascular endothelial growth factor	MESH:D009249	7422	Chemical	Gene	NOX3|compound|START_ENTITY mediated|nmod|NOX3 mediated|nsubjpass|expression expression|compound|END_ENTITY	Insulin-induced vascular_endothelial_growth_factor expression is mediated by the NADPH oxidase NOX3 .
17908694	0	NADPH	0,5	vascular_endothelial_growth_factor	45,79	NADPH	vascular endothelial growth factor	MESH:D009249	7422	Chemical	Gene	activity|compound|START_ENTITY modulates|nsubj|activity modulates|dobj|END_ENTITY	NADPH oxidase activity selectively modulates vascular_endothelial_growth_factor signaling pathways .
18853323	0	NADPH	95,100	vascular_endothelial_growth_factor	40,74	NADPH	vascular endothelial growth factor	MESH:D009249	83785(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Involvement of angiotensin_II-dependent vascular_endothelial_growth_factor gene expression via NADPH oxidase in the retina in a type 2 diabetic rat model .
24623966	0	NADPH	12,17	vascular_endothelial_growth_factor	37,71	NADPH	vascular endothelial growth factor	MESH:D009249	83785(Tax:10116)	Chemical	Gene	oxidase|nsubj|START_ENTITY oxidase|xcomp|neovascularization neovascularization|nsubj|receptor receptor|compound|END_ENTITY	Endothelial NADPH oxidase 4 mediates vascular_endothelial_growth_factor receptor 2-induced intravitreal neovascularization in a rat model of retinopathy_of_prematurity .
17765919	0	NADPH	91,96	xanthine_oxidoreductase	66,89	NADPH	xanthine oxidoreductase	MESH:D009249	497811(Tax:10116)	Chemical	Gene	oxidase|amod|START_ENTITY oxidase|amod|END_ENTITY	Nitrite confers protection against myocardial_infarction : role of xanthine_oxidoreductase , NADPH oxidase and K -LRB- ATP -RRB- channels .
2322267	0	NADPH	25,30	zeta-crystallin	68,83	NADPH	zeta-crystallin	MESH:D009249	100135507(Tax:10141)	Chemical	Gene	levels|nmod|START_ENTITY levels|dep|correlation correlation|nmod|concentration concentration|amod|END_ENTITY	Extremely high levels of NADPH in guinea_pig lens : correlation with zeta-crystallin concentration .
7909806	1	NADPH	59,64	zeta-crystallin	89,104	NADPH	zeta-crystallin	MESH:D009249	100135507(Tax:10141)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of NADPH on its interaction with zeta-crystallin .
24184564	0	NADPH_quinone	74,87	NQO1	106,110	NADPH quinone	NQO1	null	18104(Tax:10090)	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Sub-chronic sulforaphane exposure in CD-1 pregnant mice enhances maternal NADPH_quinone oxidoreductase 1 -LRB- NQO1 -RRB- activity and mRNA expression of NQO1 , glutathione_S-transferase , and glutamate-cysteine ligase : potential implications for fetal protection against toxicant exposure .
12856807	0	NADP_isocitrate	49,64	prolactin	8,17	NADP isocitrate	prolactin	null	24683(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Role of prolactin in the regulation of cytosolic NADP_isocitrate dehydrogenase in the liver of the male rat .
12942631	0	NADh	47,51	ND6	75,78	NADh	ND6	MESH:D009243	4541	Chemical	Gene	complex|compound|START_ENTITY subunit|nmod|complex gene|nmod|subunit Polymorphism|nmod|gene Polymorphism|appos|END_ENTITY	-LSB- Polymorphism of the gene for subunit 6 of the NADh dehydrogenase complex -LRB- ND6 -RRB- in ethnic russian population in Russia -RSB- .
12851698	0	NAMI-A	0,6	ODC	32,35	NAMI-A	ODC	MESH:C113661	4953	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	NAMI-A inhibits the PMA-induced ODC gene expression in ECV304 cells : involvement of PKC/Raf/Mek / ERK signalling pathway .
2329921	0	NAN-190	39,46	5-HT1A	50,56	NAN-190	5-HT1A	MESH:C058895	24473(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|receptors receptors|nummod|END_ENTITY	Mixed agonist/antagonist properties of NAN-190 at 5-HT1A receptors : behavioural and in vivo brain microdialysis studies .
25310473	0	NAND	79,83	MLC	75,78	NAND	MLC	null	23209	Chemical	Gene	Systems|compound|START_ENTITY Systems|compound|END_ENTITY	Asymmetric Programming : A Highly Reliable Metadata Allocation Strategy for MLC NAND Flash Memory-Based Sensor Systems .
25178163	0	NAP	4,7	activity-dependent_neuroprotective_protein	17,59	NAP	activity-dependent neuroprotective protein	null	23394	Chemical	Gene	motif|compound|START_ENTITY motif|nmod|END_ENTITY	The NAP motif of activity-dependent_neuroprotective_protein -LRB- ADNP -RRB- regulates dendritic spines through microtubule end binding proteins .
11501493	0	NASBA	42,47	WT1	18,21	NASBA	WT1	null	7490	Chemical	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	Quantification of WT1 mRNA by competitive NASBA in AML patients .
2211682	0	NB-598	0,6	squalene_epoxidase	42,60	NB-598	squalene epoxidase	MESH:C066059	6713	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	NB-598 : a potent competitive inhibitor of squalene_epoxidase .
12853888	0	NB1011	0,6	Ser15	15,20	NB1011	Ser15	MESH:C421011	3190208(Tax:176280)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|amod|END_ENTITY	NB1011 induces Ser15 phosphorylation of p53 and activates the G2/M checkpoint .
12853888	0	NB1011	0,6	p53	40,43	NB1011	p53	MESH:C421011	7157	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	NB1011 induces Ser15 phosphorylation of p53 and activates the G2/M checkpoint .
16095571	0	NBI-35965	32,41	CRF	147,150	NBI-35965	CRF	MESH:C504986	81648(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY abolished|nsubj|antagonist abolished|ccomp|coeruleus coeruleus|dobj|neurons neurons|acl|induced induced|nmod|END_ENTITY	The CRF -LRB- 1 -RRB- receptor antagonist , NBI-35965 , abolished the activation of locus coeruleus neurons induced by colorectal_distension and intracisternal CRF in rats .
16095571	0	NBI-35965	32,41	CRF	4,7	NBI-35965	CRF	MESH:C504986	81648(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	The CRF -LRB- 1 -RRB- receptor antagonist , NBI-35965 , abolished the activation of locus coeruleus neurons induced by colorectal_distension and intracisternal CRF in rats .
12957366	0	NBI_35965	58,67	CRF1	32,36	NBI 35965	CRF1	MESH:C504986	58959(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	A novel water-soluble selective CRF1 receptor antagonist , NBI_35965 , blunts stress-induced visceral_hyperalgesia and colonic motor function in rats .
20889731	0	NBT-272	26,33	AKT	51,54	NBT-272	AKT	MESH:C556906	207	Chemical	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	The quassinoid derivative NBT-272 targets both the AKT and ERK signaling pathways in embryonal_tumors .
1486482	0	NC-1100	36,43	Ca2	14,17	NC-1100	Ca2	MESH:C050134	54231(Tax:10116)	Chemical	Gene	blocker|appos|START_ENTITY blocker|amod|END_ENTITY	A new type of Ca2 + channel blocker , NC-1100 , inhibits the low - and high-threshold Ca2 + currents in the rat CNS neurons .
1486482	0	NC-1100	36,43	Ca2	82,85	NC-1100	Ca2	MESH:C050134	54231(Tax:10116)	Chemical	Gene	blocker|appos|START_ENTITY type|nmod|blocker inhibits|nsubj|type inhibits|dobj|currents currents|amod|END_ENTITY	A new type of Ca2 + channel blocker , NC-1100 , inhibits the low - and high-threshold Ca2 + currents in the rat CNS neurons .
19703310	0	NC2213	0,6	methionine_aminopeptidase_2	16,43	NC2213	methionine aminopeptidase 2	MESH:C547078	10988	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	NC2213 : a novel methionine_aminopeptidase_2 inhibitor in human colon_cancer HT29 cells .
25679052	0	NCB	103,106	P-Glycoprotein	118,132	NCB	P-Glycoprotein	null	610926(Tax:9615)	Chemical	Gene	Binding|compound|START_ENTITY Binding|nmod|END_ENTITY	Inhibitory Effects of Neochamaejasmin_B on P-Glycoprotein in MDCK-hMDR1 Cells and Molecular Docking of NCB Binding in P-Glycoprotein .
12098579	0	NCS-382	21,28	gamma-hydroxybutyrate_receptor	40,70	NCS-382	gamma-hydroxybutyrate receptor	MESH:C066471	306771(Tax:10116)	Chemical	Gene	Stereoselectivity|nmod|START_ENTITY binding|nsubj|Stereoselectivity binding|xcomp|END_ENTITY	Stereoselectivity of NCS-382 binding to gamma-hydroxybutyrate_receptor in the rat brain .
1773824	0	NCS-382	48,55	gamma-hydroxybutyrate_receptor	59,89	NCS-382	gamma-hydroxybutyrate receptor	MESH:C066471	306771(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Anti-sedative and anti-cataleptic properties of NCS-382 , a gamma-hydroxybutyrate_receptor antagonist .
21784969	0	NCS_613	0,7	PDE4	31,35	NCS 613	PDE4	MESH:C106583	5141	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	NCS_613 , a potent and specific PDE4 inhibitor , displays anti-inflammatory effects on human lung tissues .
24695638	0	NCoAs	101,106	Dub3	35,39	NCoAs	Dub3	null	625530(Tax:10090)	Chemical	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Cell cycle-dependent expression of Dub3 , Nanog and the p160 family of nuclear receptor coactivators -LRB- NCoAs -RRB- in mouse embryonic stem cells .
22396044	0	NDMC101	34,41	NFATc1	51,57	NDMC101	NFATc1	MESH:C577570	18018(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	A benzamide-linked small molecule NDMC101 inhibits NFATc1 and NF-kB activity : a potential osteoclastogenesis inhibitor for experimental arthritis .
23095879	0	NDP	51,54	CPT-11	27,33	NDP	CPT-11	CHEBI:16862	963084(Tax:115711)	Chemical	Gene	irinotecan|appos|START_ENTITY irinotecan|appos|END_ENTITY	Combination of irinotecan -LRB- CPT-11 -RRB- and nedaplatin -LRB- NDP -RRB- for recurrent patients with uterine_cervical_cancer .
23618865	0	NE-100	31,37	sigma-1_receptor	2,18	NE-100	sigma-1 receptor	MESH:C083832	18391(Tax:10090)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	A sigma-1_receptor antagonist -LRB- NE-100 -RRB- prevents tunicamycin-induced cell death via GRP78 induction in hippocampal cells .
14703506	7	NEFA	1358,1362	LPL	1377,1380	NEFA	LPL	MESH:D005230	4023	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	Therefore , 1 -RRB- the clearance of TG-rich lipoproteins is enhanced by ASP through increasing TG storage and relieving NEFA inhibition of LPL ; _ and_2 -RRB- the effectiveness of adipose tissue trapping of LPL-derived NEFAs determines overall LPL activity , which in turn determines the efficiency of postprandial TG clearance .
12079885	0	NEFA	19,23	insulin	66,73	NEFA	insulin	MESH:D005230	3630	Chemical	Gene	elevation|nmod|START_ENTITY causes|nsubj|elevation causes|nmod|effect effect|nmod|rate rate|compound|END_ENTITY	Acute elevation of NEFA causes hyperinsulinemia without effect on insulin secretion rate in healthy human subjects .
15931604	9	NEFA	1884,1888	insulin	1917,1924	NEFA	insulin	MESH:D005230	3630	Chemical	Gene	seems|nsubj|START_ENTITY seems|xcomp|associated associated|nmod|independent independent|compound|END_ENTITY	In conclusion , NEFA seems to be associated with insulin secretion independent of obesity or HOMA-IR .
16918948	7	NEFA	1314,1318	insulin	1283,1290	NEFA	insulin	MESH:D005230	3630	Chemical	Gene	resistance|nmod|START_ENTITY resistance|compound|END_ENTITY	In partial correlation analyses , significant associations were found : glycaemic level -LRB- HbA1c -RRB- with insulin resistance , TNF-alpha , CRP and basal and ACTH-stimulated cortisol levels , insulin resistance with plasma NEFA , TNF-alpha and stimulated cortisol levels .
17881684	0	NEFA	20,24	insulin	82,89	NEFA	insulin	MESH:D005230	280829(Tax:9913)	Chemical	Gene	concentration|compound|START_ENTITY Reduction|nmod|concentration enhances|nsubj|Reduction enhances|nmod|END_ENTITY	Reduction of plasma NEFA concentration by nicotinic_acid enhances the response to insulin in feed-restricted Holstein cows .
9585399	0	NEFA	0,4	insulin	54,61	NEFA	insulin	MESH:D005230	3630	Chemical	Gene	elevation|compound|START_ENTITY enhances|nsubj|elevation enhances|dobj|secretion secretion|compound|END_ENTITY	NEFA elevation during a hyperglycaemic clamp enhances insulin secretion .
9585399	6	NEFA	742,746	insulin	846,853	NEFA	insulin	MESH:D005230	3630	Chemical	Gene	levels|compound|START_ENTITY enhance|nsubj|levels enhance|dobj|glucose glucose|acl|stimulated stimulated|dobj|levels levels|compound|END_ENTITY	Elevated NEFA levels -LRB- approximately 4000 micromol l -LRB- -1 -RRB- -RRB- did not enhance basal or first phase glucose stimulated insulin levels .
16280327	1	NF-kappaB	104,113	Bcl3	165,169	NF-kappaB	Bcl3	null	602	Chemical	Gene	complexes|amod|START_ENTITY complexes|nmod|END_ENTITY	Bcl10 is up-regulated by NF-kappaB and phosphorylated by Akt1 and then complexes with Bcl3 to enter the nucleus .
11171565	8	NF-kappaB	1159,1168	CCK	1141,1144	NF-kappaB	p65	null	25716(Tax:10116)	Chemical	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	However , CCK stimulated NF-kappaB activation in Chinese_hamster ovary-CCK -LRB- A -RRB- cells , which do not express trypsinogen , indicating that trypsin is not necessary for CCK activation of NF-kappaB .
18070230	0	NF-kappaB	22,31	CD4	111,114	NF-kappaB	CD4	null	920	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Selective blockade of NF-kappaB by novel mutated IkappaBalpha suppresses CD3/CD28-induced activation of memory CD4 + T cells in asthma .
17202411	0	NF-kappaB	102,111	IkappaBalpha	116,128	NF-kappaB	IkappaBalpha	null	4792	Chemical	Gene	START_ENTITY|nmod|regulation regulation|compound|END_ENTITY	Adipocyte enhancer-binding protein-1 promotes macrophage inflammatory responsiveness by up-regulating NF-kappaB via IkappaBalpha negative regulation .
18579519	0	NF-kappaB	44,53	LC8	19,22	NF-kappaB	LC8	null	8655	Chemical	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Dynein light chain LC8 negatively regulates NF-kappaB through the redox-dependent interaction with IkappaBalpha .
16056233	0	NF676	91,96	skeletal_muscle_ryanodine_receptor	32,66	NF676	skeletal muscle ryanodine receptor	null	6261	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Use-dependent inhibition of the skeletal_muscle_ryanodine_receptor by the suramin analogue NF676 .
19369336	0	NFX1-123	0,8	hTERT	19,24	NFX1-123	hTERT	null	7015	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	NFX1-123 increases hTERT expression and telomerase activity posttranscriptionally in human_papillomavirus_type_16 E6 keratinocytes .
10348036	0	NG-061	26,32	nerve_growth_factor	76,95	NG-061	nerve growth factor	MESH:C119398	310738(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|effect effect|nmod|END_ENTITY	A novel fungal metabolite NG-061 enhances and mimics neurotrophic effect of nerve_growth_factor -LRB- NGF -RRB- on neurite outgrowth in PC12 cells .
7531495	0	NG-hydroxy-L-arginine	41,62	nitric_oxide_synthase	66,87	NG-hydroxy-L-arginine	nitric oxide synthase	CHEBI:28538	18125(Tax:10090)	Chemical	Gene	oxidation|nmod|START_ENTITY oxidation|nmod|END_ENTITY	Hydrogen_peroxide-supported oxidation of NG-hydroxy-L-arginine by nitric_oxide_synthase .
1282961	0	NG-monomethyl-L-arginine	71,95	endothelin-1	11,23	NG-monomethyl-L-arginine	endothelin-1	CHEBI:28229	24323(Tax:10116)	Chemical	Gene	production|nmod|START_ENTITY Effects|nmod|production Effects|nmod|END_ENTITY	Effects of endothelin-1 and inhibition of nitric_oxide production with NG-monomethyl-L-arginine on arterial pressure and regional blood flow in anesthetized rats .
8139094	0	NG-monomethyl-L-arginine	11,35	endothelin-1	109,121	NG-monomethyl-L-arginine	endothelin-1	CHEBI:28229	24323(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|acl|END_ENTITY	Effects of NG-monomethyl-L-arginine , indomethacin , and aspirin on the vasodepressor response to low doses of endothelin-1 and endothelin-3 in rats .
1725372	0	NG-nitro-L-arginine	11,30	endothelin-3	65,77	NG-nitro-L-arginine	endothelin-3	null	403406(Tax:9615)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|responses responses|nmod|END_ENTITY	Effects of NG-nitro-L-arginine on renal hemodynamic responses to endothelin-3 in anesthetized dogs .
25842244	0	NH125	0,5	CPEB3	27,32	NH125	CPEB3	MESH:C414024	208922(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|level level|nmod|END_ENTITY	NH125 reduces the level of CPEB3 , an RNA binding protein , to promote synaptic GluA2 expression .
12183411	0	NH2	23,26	EWS	19,22	NH2	EWS	CHEBI:29345	2130	Chemical	Gene	terminus|compound|START_ENTITY terminus|compound|END_ENTITY	Interaction of the EWS NH2 terminus with BARD1 links the Ewing 's _ sarcoma gene to a common tumor suppressor pathway .
3096623	0	NH2	88,91	GHRH	77,81	NH2	GHRH	CHEBI:29345	2691	Chemical	Gene	START_ENTITY|nsubj|effect effect|appos|END_ENTITY	The effect of intravenous , subcutaneous , and intranasal GH-RH analog , -LSB- Nle27 -RSB- GHRH -LRB- 1-29 -RRB- - NH2 , on growth_hormone secretion in normal men : dose-response relationships .
12679472	0	NH2	59,62	GLP-1	11,16	NH2	GLP-1	CHEBI:29345	2641	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of GLP-1 - -LRB- 7-36 -RRB- NH2 , GLP-1 - -LRB- 7-37 -RRB- , and GLP-1 - -LRB- 9-36 -RRB- NH2 on intravenous glucose tolerance and glucose-induced insulin secretion in healthy humans .
8509445	0	NH2	7,10	GLUT-4	0,6	NH2	GLUT-4	CHEBI:29345	6517	Chemical	Gene	terminus|compound|START_ENTITY terminus|compound|END_ENTITY	GLUT-4 NH2 terminus contains a phenylalanine-based targeting motif that regulates intracellular sequestration .
2859987	1	NH2	182,185	GRF	172,175	NH2	GRF	CHEBI:29345	29446(Tax:10116)	Chemical	Gene	Discovery|dep|START_ENTITY Discovery|nmod|END_ENTITY	Discovery of -LRB- N-Ac-Tyr1 , D-Phe2 -RRB- - GRF -LRB- 1-29 -RRB- - NH2 as a VIP antagonist .
2994998	0	NH2	172,175	GRF	181,184	NH2	GRF	CHEBI:29345	29446(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|antagonist antagonist|compound|END_ENTITY	Structural requirements for the activation of rat anterior pituitary adenylate cyclase by growth_hormone-releasing_factor -LRB- GRF -RRB- : discovery of -LRB- N-Ac-Tyr1 , D-Arg2 -RRB- - GRF -LRB- 1-29 -RRB- - NH2 as a GRF antagonist on membranes .
2866496	0	NH2	68,71	Growth_hormone	0,14	NH2	Growth hormone	CHEBI:29345	2688	Chemical	Gene	responses|dep|START_ENTITY responses|amod|END_ENTITY	Growth_hormone responses to growth_hormone-releasing_hormone -LRB- 1-29 -RRB- - NH2 and a D-Ala2 analog in normal men .
8329829	0	NH2	107,110	Growth_hormone	0,14	NH2	Growth hormone	CHEBI:29345	2688	Chemical	Gene	infusion|dep|START_ENTITY infusion|amod|END_ENTITY	Growth_hormone -LRB- GH -RRB- profiles in response to continuous subcutaneous infusion of GH-releasing hormone -LRB- 1-29 -RRB- - NH2 in children with GH_deficiency .
19013489	0	NH2	66,69	PTH	37,40	NH2	PTH	CHEBI:29345	24694(Tax:10116)	Chemical	Gene	activity|dep|START_ENTITY activity|nmod|END_ENTITY	Hypertensive activity of synthesized PTH -LRB- 25-34 -RRB- and Ac-PTH -LRB- 25-30 -RRB- - NH2 in rats .
26928204	0	NH2	80,83	RhoA	104,108	NH2	RhoA	CHEBI:29345	387	Chemical	Gene	kinase|compound|START_ENTITY kinase|nmod|END_ENTITY	Uni-axial stretch induces actin stress fiber reorganization and activates c-Jun NH2 terminal kinase via RhoA and Rho kinase in human bladder smooth muscle cells .
2859987	1	NH2	182,185	VIP	191,194	NH2	VIP	CHEBI:29345	117064(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|antagonist antagonist|compound|END_ENTITY	Discovery of -LRB- N-Ac-Tyr1 , D-Phe2 -RRB- - GRF -LRB- 1-29 -RRB- - NH2 as a VIP antagonist .
17711847	0	NH2	160,163	WIP	156,159	NH2	WIP	CHEBI:29345	7456	Chemical	Gene	terminus|compound|START_ENTITY terminus|compound|END_ENTITY	Structure-function analysis of the WIP role in T cell receptor-stimulated NFAT activation : evidence that WIP-WASP dissociation is not required and that the WIP NH2 terminus is inhibitory .
15795326	0	NH2	94,97	c-Jun	79,84	NH2	c-Jun	CHEBI:29345	3725	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Celecoxib decreases endothelial tissue factor expression through inhibition of c-Jun terminal NH2 kinase phosphorylation .
9790915	0	NH2	26,29	c-Jun	20,25	NH2	c-Jun	CHEBI:29345	3725	Chemical	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Exercise stimulates c-Jun NH2 kinase activity and c-Jun transcriptional activity in human skeletal muscle .
10594518	0	NH2	77,80	growth_hormone	125,139	NH2	growth hormone	CHEBI:29345	2688	Chemical	Gene	GHRH|appos|START_ENTITY growth_hormone-releasing_hormone|dep|GHRH roles|nmod|growth_hormone-releasing_hormone roles|nmod|END_ENTITY	The relative roles of continuous growth_hormone-releasing_hormone -LRB- GHRH -LRB- 1-29 -RRB- NH2 -RRB- and intermittent somatostatin -LRB- 1-14 -RRB- -LRB- SS -RRB- in growth_hormone -LRB- GH -RRB- pulse generation : studies in normal and post cranial irradiated individuals .
1430086	0	NH2	165,168	growth_hormone	70,84	NH2	growth hormone	CHEBI:29345	2688	Chemical	Gene	1-44|dep|START_ENTITY 1-44|nmod|improvement improvement|dep|secretion secretion|amod|END_ENTITY	Sustained improvement in growth velocity and recovery from suboptimal growth_hormone -LRB- GH -RRB- secretion after treatment with human pituitary GH-releasing hormone - -LRB- 1-44 -RRB- - NH2 .
2877535	0	NH2	92,95	growth_hormone	99,113	NH2	growth hormone	CHEBI:29345	2688	Chemical	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	The effects of intranasal insufflation of growth_hormone_releasing_factor analogue GRF_1-29 NH2 on growth_hormone secretion in children with short_stature .
2880720	0	NH2	55,58	growth_hormone	113,127	NH2	growth hormone	CHEBI:29345	2688	Chemical	Gene	GRF|dep|START_ENTITY factor|dep|GRF Testing|nmod|factor Testing|nmod|deficiency deficiency|amod|END_ENTITY	Testing with growth_hormone-releasing factor -LRB- GRF -LRB- 1-29 -RRB- NH2 -RRB- and somatomedin_C measurements for the evaluation of growth_hormone deficiency .
3096623	0	NH2	88,91	growth_hormone	96,110	NH2	growth hormone	CHEBI:29345	2688	Chemical	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	The effect of intravenous , subcutaneous , and intranasal GH-RH analog , -LSB- Nle27 -RSB- GHRH -LRB- 1-29 -RRB- - NH2 , on growth_hormone secretion in normal men : dose-response relationships .
8329825	0	NH2	59,62	growth_hormone	82,96	NH2	growth hormone	CHEBI:29345	2688	Chemical	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	Pharmacokinetics of growth_hormone-releasing hormone -LRB- 1-29 -RRB- - NH2 and stimulation of growth_hormone secretion in healthy subjects after intravenous or intranasal administration .
8329828	0	NH2	68,71	growth_hormone	127,141	NH2	growth hormone	CHEBI:29345	2688	Chemical	Gene	administration|dep|START_ENTITY administration|dep|effects effects|nmod|secretion secretion|amod|END_ENTITY	Intranasal administration of growth_hormone-releasing hormone -LRB- 1-29 -RRB- - NH2 in children with growth_hormone deficiency : effects on growth_hormone secretion and growth .
8329828	0	NH2	68,71	growth_hormone	89,103	NH2	growth hormone	CHEBI:29345	2688	Chemical	Gene	START_ENTITY|nmod|children children|nmod|deficiency deficiency|amod|END_ENTITY	Intranasal administration of growth_hormone-releasing hormone -LRB- 1-29 -RRB- - NH2 in children with growth_hormone deficiency : effects on growth_hormone secretion and growth .
8329830	0	NH2	74,77	growth_hormone	23,37	NH2	growth hormone	CHEBI:29345	2688	Chemical	Gene	study|dep|START_ENTITY study|nmod|END_ENTITY	A comparative study of growth_hormone -LRB- GH -RRB- and GH-releasing hormone -LRB- 1-29 -RRB- - NH2 for stimulation of growth in children with GH_deficiency .
16817143	0	NH2	39,42	interleukin-2	63,76	NH2	interleukin-2	CHEBI:29345	3558	Chemical	Gene	START_ENTITY|nmod|secretion secretion|nmod|END_ENTITY	-LSB- Evaluation of the effect of GHRH -LRB- 1-44 -RRB- NH2 on the secretion of interleukin-2 -LRB- IL-2 -RRB- and soluble IL-2_receptor_alpha -LRB- sIL-2Ralpha -RRB- from human peripheral blood mononuclear cells in vitro -RSB- .
8544854	0	NH2	63,66	interleukin-2	84,97	NH2	interleukin-2	CHEBI:29345	3558	Chemical	Gene	area|compound|START_ENTITY area|nmod|END_ENTITY	Characterization of a monoclonal antibody directed against the NH2 terminal area of interleukin-2 -LRB- IL-2 -RRB- and inhibiting specifically the binding of IL-2 to IL-2 receptor beta chain -LRB- IL-2R_beta -RRB- .
17690186	0	NH2	6,9	mitogen-activated_protein_kinase_phosphatase-1	65,111	NH2	mitogen-activated protein kinase phosphatase-1	CHEBI:29345	1843	Chemical	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	c-Jun NH2 terminal kinase activation and decreased expression of mitogen-activated_protein_kinase_phosphatase-1 play important roles in invasion and angiogenesis of urothelial_carcinomas .
12731862	0	NH2	72,75	multidrug_resistance_protein_1	105,135	NH2	multidrug resistance protein 1	CHEBI:29345	4363	Chemical	Gene	region|compound|START_ENTITY region|nmod|END_ENTITY	Functional and structural consequences of cysteine substitutions in the NH2 proximal region of the human multidrug_resistance_protein_1 -LRB- MRP1/ABCC1 -RRB- .
10643813	0	NH2	47,50	nociceptin_receptor	54,73	NH2	nociceptin receptor	CHEBI:29345	100766638	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Antagonistic effects of -LSB- Nphe1 -RSB- nociceptin -LRB- 1-13 -RRB- NH2 on nociceptin_receptor mediated inhibition of cAMP formation in Chinese_hamster ovary cells stably expressing the recombinant human nociceptin_receptor .
2462199	0	NH2-senktide	15,27	neurokinin_B	41,53	NH2-senktide	neurokinin B	MESH:C057852	29191(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	The tachykinin NH2-senktide , a selective neurokinin_B receptor agonist , is a very potent inhibitor of salt appetite in the rat .
16574458	0	NH3	25,28	RhAG	8,12	NH3	RhAG	CHEBI:16134	19743(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY Role|nmod|transport Role|nmod|END_ENTITY	Role of RhAG and AQP1 in NH3 and CO2 gas transport in red cell ghosts : a stopped-flow analysis .
6776823	0	NH4Cl	10,15	PTH	44,47	NH4Cl	PTH	CHEBI:31206	5741	Chemical	Gene	START_ENTITY|nmod|response response|nmod|END_ENTITY	Effect of NH4Cl on phosphaturic response to PTH in the hamster : dissociation from acidemia .
24852368	0	NIM811	0,6	cyclophilin	10,21	NIM811	cyclophilin	MESH:C090438	335519(Tax:7955)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	NIM811 , a cyclophilin inhibitor without immunosuppressive activity , is beneficial in collagen VI congenital_muscular_dystrophy models .
10530801	0	NK-104	10,16	HMG-CoA_reductase	34,51	NK-104	HMG-CoA reductase	MESH:C108475	25675(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effect of NK-104 , a new synthetic HMG-CoA_reductase inhibitor , on triglyceride secretion and fatty_acid oxidation in rat liver .
11419739	0	NK-104	158,164	HMG-CoA_reductase	185,202	NK-104	HMG-CoA reductase	MESH:C108475	3156	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Simultaneous determination of taxol and its metabolites in microsomal samples by a simple thin-layer chromatography radioactivity assay -- inhibitory effect of NK-104 , a new inhibitor of HMG-CoA_reductase .
12048134	0	NK-104	39,45	HMG-CoA_reductase	54,71	NK-104	HMG-CoA reductase	MESH:C108475	3156	Chemical	Gene	pitavastatin|appos|START_ENTITY treatment|nmod|pitavastatin treatment|appos|inhibitor inhibitor|amod|END_ENTITY	Long-term treatment with pitavastatin -LRB- NK-104 -RRB- , a new HMG-CoA_reductase inhibitor , of patients with heterozygous familial_hypercholesterolemia .
10428299	0	NK-104	0,6	apolipoprotein_B-100	86,106	NK-104	apolipoprotein B-100	MESH:C108475	338	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|secretion secretion|amod|END_ENTITY	NK-104 , a potent 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor , decreases apolipoprotein_B-100 secretion from Hep G2 cells .
1311270	0	NK3	103,106	neurokinin_B	108,120	NK3	neurokinin B	null	29191(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Stable expression of high affinity NK1 -LRB- substance P -RRB- and NK2 -LRB- neurokinin_A -RRB- receptors but low affinity NK3 -LRB- neurokinin_B -RRB- receptors in transfected CHO cells .
18596031	0	NK314	0,5	topoisomerase_II	9,25	NK314	topoisomerase II	MESH:C522060	7153	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	NK314 , a topoisomerase_II inhibitor that specifically targets the alpha isoform .
12396033	0	NK3201	50,56	chymase	31,38	NK3201	chymase	MESH:C437945	1215	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Oral administration of a novel chymase inhibitor , NK3201 , prevents peritoneal adhesion formation in hamsters .
14960660	0	NK3201	151,157	chymase	11,18	NK3201	chymase	MESH:C437945	1215	Chemical	Gene	acetamide|appos|START_ENTITY -|dep|acetamide inhibitor|appos|- inhibitor|compound|END_ENTITY	A specific chymase inhibitor , 2 - -LRB- 5-formylamino-6-oxo-2-phenyl-1 ,6 - dihydropyrimidine-1-yl -RRB- - N - -LSB- -LSB- 3,4-dioxo-1-phenyl-7 - -LRB- 2-pyridyloxy -RRB- -RSB- -2 - heptyl -RSB- acetamide -LRB- NK3201 -RRB- , suppresses development of abdominal_aortic_aneurysm in hamsters .
15189779	0	NK3201	30,36	chymase	11,18	NK3201	chymase	MESH:C437945	1215	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	A specific chymase inhibitor , NK3201 , suppresses bleomycin-induced pulmonary_fibrosis in hamsters .
11102646	0	NKP608	0,6	NK-1_receptor	20,33	NKP608	NK-1 receptor	MESH:C414491	24807(Tax:10116)	Chemical	Gene	START_ENTITY|dep|antagonist antagonist|compound|END_ENTITY	NKP608 : a selective NK-1_receptor antagonist with anxiolytic-like effects in the social interaction and social exploration test in rats .
12110470	0	NKP608	21,27	NK1-receptor	31,43	NKP608	NK1-receptor	MESH:C414491	24807(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|antagonist antagonist|compound|END_ENTITY	Anxiolytic effect of NKP608 , a NK1-receptor antagonist , in the social investigation test in gerbils .
11041322	0	NKP608	0,6	NK1_receptor	11,23	NKP608	NK1 receptor	MESH:C414491	24807(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	NKP608 , an NK1_receptor antagonist , has an anxiolytic action in the social interaction test in rats .
14643166	0	NKP608	53,59	NK1_receptor	18,30	NKP608	NK1 receptor	MESH:C414491	100135626(Tax:10141)	Chemical	Gene	Effect|appos|START_ENTITY Effect|nmod|antagonist antagonist|amod|END_ENTITY	Effect of a novel NK1_receptor selective antagonist -LRB- NKP608 -RRB- on citric_acid induced cough and airway_obstruction .
18440302	0	NL9980	93,99	nm23-H1	103,110	NL9980	nm23-H1	null	4830	Chemical	Gene	START_ENTITY|nmod|gene gene|amod|END_ENTITY	Alteration in gene expression profile and biological behavior in human lung_cancer cell line NL9980 by nm23-H1 gene silencing .
18815136	0	NM23-H1	27,34	MIF	79,82	NM23-H1	MIF	null	17319(Tax:10090)	Chemical	Gene	interaction|nmod|START_ENTITY interaction|appos|END_ENTITY	Direct interaction between NM23-H1 and macrophage_migration_inhibitory_factor -LRB- MIF -RRB- is critical for alleviation of MIF-mediated suppression of p53 activity .
22861201	0	NMDA	118,122	5-HT1A	127,133	NMDA	5-HT1A	CHEBI:6121	24473(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|receptors receptors|nummod|END_ENTITY	Anti-dyskinetic mechanisms of amantadine and dextromethorphan in the 6-OHDA rat model of Parkinson 's _ disease : role of NMDA vs. 5-HT1A receptors .
17187986	0	NMDA	77,81	5-lipoxygenase	100,114	NMDA	5-lipoxygenase	D016202	25290(Tax:10116)	Chemical	Gene	activation|compound|START_ENTITY activation|amod|END_ENTITY	Baicalin attenuates oxygen-glucose_deprivation-induced injury via inhibiting NMDA receptor-mediated 5-lipoxygenase activation in rat cortical neurons .
16621159	0	NMDA	14,18	AKT	32,35	NMDA	AKT	CHEBI:6121	207	Chemical	Gene	receptors|compound|START_ENTITY receptors|nmod|END_ENTITY	Modulation of NMDA receptors by AKT kinase .
12270033	0	NMDA	42,46	Akt	0,3	NMDA	Akt	CHEBI:6121	11651(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY mediates|dobj|effect mediates|nsubj|END_ENTITY	Akt mediates the anti-apoptotic effect of NMDA but not that induced by potassium depolarization in cultured cerebellar granule cells .
10321491	0	NMDA	0,4	BDNF	13,17	NMDA	BDNF	CHEBI:6121	24225(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	NMDA induces BDNF expression in the albino rat retina in vivo .
10492007	0	NMDA	28,32	BDNF	52,56	NMDA	BDNF	CHEBI:6121	627	Chemical	Gene	receptors|compound|START_ENTITY Blockade|nmod|receptors prevents|nsubj|Blockade prevents|dobj|enhancement enhancement|amod|END_ENTITY	Blockade of NR2B-containing NMDA receptors prevents BDNF enhancement of glutamatergic transmission in hippocampal neurons .
10686066	0	NMDA	63,67	BDNF	24,28	NMDA	BDNF	CHEBI:6121	627	Chemical	Gene	subunits|compound|START_ENTITY levels|nmod|subunits effects|nmod|levels effects|nmod|END_ENTITY	Differential effects of BDNF , ADNF9 , and TNFalpha on levels of NMDA receptor subunits , calcium homeostasis , and neuronal vulnerability to excitotoxicity .
15306120	3	NMDA	617,621	BDNF	654,658	NMDA	FGF2	CHEBI:6121	54250(Tax:10116)	Chemical	Gene	decreased|nsubj|START_ENTITY decreased|dobj|END_ENTITY	A 100 microM NMDA alone decreased NT-3 , increased BDNF , but had no effect on NGF or FGF2 .
15515007	0	NMDA	33,37	BDNF	0,4	NMDA	BDNF	CHEBI:6121	12064(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY enhancement|nmod|receptors enhancement|amod|END_ENTITY	BDNF enhancement of postsynaptic NMDA receptors is blocked by ethanol .
15538182	0	NMDA	15,19	BDNF	0,4	NMDA	BDNF	CHEBI:6121	12064(Tax:10090)	Chemical	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	BDNF regulates NMDA receptor activity in developing retinal_ganglion_cells .
16125841	0	NMDA	76,80	BDNF	46,50	NMDA	BDNF	CHEBI:6121	24225(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY mediated|nmod|receptors mediated|nsubj|Effects Effects|nmod|brain-derived_neurotrophic_factor brain-derived_neurotrophic_factor|appos|END_ENTITY	Effects of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- on activity mediated by NMDA receptors in rat spinal cord cultures .
16125841	5	NMDA	892,896	BDNF	938,942	NMDA	BDNF	CHEBI:6121	24225(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY potentiation|nmod|receptors mediated|nmod|potentiation mediated|advcl|found found|ccomp|potentiates potentiates|nsubj|END_ENTITY	This increase of activity is suggested to be mediated by a potentiation of the postsynaptic NMDA receptors because it has been found that BDNF potentiates the NMDA-evoked depolarization in cultures incubated with BDNF for 10 min .
17428676	0	NMDA	45,49	BDNF	0,4	NMDA	BDNF	CHEBI:6121	627	Chemical	Gene	receptors|compound|START_ENTITY expression|nmod|receptors regulates|dobj|expression regulates|nsubj|END_ENTITY	BDNF regulates the expression and traffic of NMDA receptors in cultured hippocampal neurons .
18842955	0	NMDA	19,23	BDNF	0,4	NMDA	BDNF	CHEBI:6121	627	Chemical	Gene	receptors|compound|START_ENTITY modulation|nmod|receptors modulation|compound|END_ENTITY	BDNF modulation of NMDA receptors is activity dependent .
20079352	0	NMDA	113,117	BDNF	32,36	NMDA	BDNF	CHEBI:6121	24225(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY activation|nmod|receptors END_ENTITY|nmod|activation	Contribution of the spinal cord BDNF to the development of neuropathic_pain by activation of the NR2B-containing NMDA receptors in rats with spinal nerve ligation .
20592208	0	NMDA	39,43	BDNF	4,8	NMDA	BDNF	CHEBI:6121	12064(Tax:10090)	Chemical	Gene	plasticity|compound|START_ENTITY impairs|dobj|plasticity impairs|nsubj|polymorphism polymorphism|compound|END_ENTITY	The BDNF Val66Met polymorphism impairs NMDA receptor-dependent synaptic plasticity in the hippocampus .
20965158	0	NMDA	200,204	BDNF	105,109	NMDA	BDNF	CHEBI:6121	24225(Tax:10116)	Chemical	Gene	receptor|appos|START_ENTITY evoked|nmod|receptor evoked|nsubj|Activation Activation|nmod|transcription transcription|acl|induced induced|nmod|brain-derived_neurotrophic_factor brain-derived_neurotrophic_factor|appos|END_ENTITY	Activation of tyrosine_hydroxylase -LRB- TH -RRB- gene transcription induced by brain-derived_neurotrophic_factor -LRB- BDNF -RRB- and its selective inhibition through Ca -LRB- 2 + -RRB- signals evoked via the N-methyl-D-aspartate -LRB- NMDA -RRB- receptor .
24184316	0	NMDA	55,59	BDNF	31,35	NMDA	BDNF	CHEBI:6121	24225(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY expression|nmod|receptor expression|amod|END_ENTITY	The ganglioside GQ1b regulates BDNF expression via the NMDA receptor signaling pathway .
24611998	0	NMDA	50,54	BDNF	0,4	NMDA	BDNF	CHEBI:6121	24225(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY potentiates|dobj|receptors potentiates|nsubj|END_ENTITY	BDNF released during neuropathic_pain potentiates NMDA receptors in primary afferent terminals .
24621058	0	NMDA	63,67	BDNF	35,39	NMDA	BDNF	CHEBI:6121	24225(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|content content|compound|END_ENTITY	Dietary omega-3 deficiency reduces BDNF content and activation NMDA receptor and Fyn in dorsal hippocampus : implications on persistence of long-term memory in rats .
25277075	0	NMDA	0,4	BDNF	94,98	NMDA	BDNF	CHEBI:6121	627	Chemical	Gene	dysregulation|compound|START_ENTITY dysregulation|dep|depression depression|nmod|downregulation downregulation|compound|END_ENTITY	NMDA receptor dysregulation in chronic state : A possible mechanism underlying depression with BDNF downregulation .
25447233	0	NMDA	140,144	BDNF	0,4	NMDA	BDNF	CHEBI:6121	24225(Tax:10116)	Chemical	Gene	activation|compound|START_ENTITY associated|dobj|activation SHP2|acl|associated potentiation|nmod|SHP2 induction|nmod|potentiation contributes|nmod|induction contributes|nsubj|END_ENTITY	BDNF contributes to the development of neuropathic_pain by induction of spinal long-term potentiation via SHP2 associated GluN2B-containing NMDA receptors activation in rats with spinal nerve ligation .
25467984	0	NMDA	30,34	BDNF	67,71	NMDA	BDNF	CHEBI:6121	12064(Tax:10090)	Chemical	Gene	Receptors|compound|START_ENTITY Role|nmod|Receptors Role|nmod|Secretion Secretion|compound|END_ENTITY	Essential Role of Presynaptic NMDA Receptors in Activity-Dependent BDNF Secretion and Corticostriatal LTP .
26279570	0	NMDA	33,37	BDNF	0,4	NMDA	BDNF	D016202	12064(Tax:10090)	Chemical	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	BDNF Reduces Toxic Extrasynaptic NMDA Receptor Signaling via Synaptic NMDA Receptors and Nuclear-Calcium-Induced Transcription of inhba/Activin A. UNASSIGNED : The health of neurons is critically dependent on the relative signaling intensities of survival-promoting synaptic and death-inducing extrasynaptic NMDA receptors .
26279570	0	NMDA	70,74	BDNF	0,4	NMDA	BDNF	D016202	12064(Tax:10090)	Chemical	Gene	Receptors|compound|START_ENTITY Signaling|nmod|Receptors Signaling|compound|END_ENTITY	BDNF Reduces Toxic Extrasynaptic NMDA Receptor Signaling via Synaptic NMDA Receptors and Nuclear-Calcium-Induced Transcription of inhba/Activin A. UNASSIGNED : The health of neurons is critically dependent on the relative signaling intensities of survival-promoting synaptic and death-inducing extrasynaptic NMDA receptors .
26289587	0	NMDA	25,29	BDNF	11,15	NMDA	BDNF	D016202	24225(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY pathways|nsubj|phosphorylation augments|ccomp|pathways augments|nsubj|END_ENTITY	Endogenous BDNF augments NMDA receptor phosphorylation in the spinal cord via PLCy , PKC , and PI3K/Akt pathways during colitis .
26289587	0	NMDA	25,29	BDNF	11,15	NMDA	BDNF	D016202	24225(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY pathways|nsubj|phosphorylation augments|ccomp|pathways augments|nsubj|END_ENTITY	Endogenous BDNF augments NMDA receptor phosphorylation in the spinal cord via PLCy , PKC , and PI3K/Akt pathways during colitis .
26562663	0	NMDA	94,98	BDNF	26,30	NMDA	BDNF	D016202	12064(Tax:10090)	Chemical	Gene	7-chlorokynurenic_acid|compound|START_ENTITY effect|nmod|7-chlorokynurenic_acid involved|nmod|effect involved|nsubjpass|Activation Activation|nmod|signaling signaling|compound|END_ENTITY	Activation of hippocampal BDNF signaling is involved in the antidepressant-like effect of the NMDA receptor antagonist 7-chlorokynurenic_acid .
7906555	0	NMDA	14,18	BDNF	74,78	NMDA	BDNF	CHEBI:6121	627	Chemical	Gene	receptors|compound|START_ENTITY Activation|nmod|receptors increases|nsubj|Activation increases|dobj|expression expression|compound|mRNA mRNA|appos|END_ENTITY	Activation of NMDA receptors increases brain-derived_neurotrophic_factor -LRB- BDNF -RRB- mRNA expression in the hippocampal formation .
8730826	0	NMDA	15,19	BDNF	43,47	NMDA	BDNF	CHEBI:6121	12064(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY Enhancement|nmod|receptor maturation|nsubj|Enhancement maturation|nmod|END_ENTITY	Enhancement of NMDA receptor maturation by BDNF in cultured mouse cerebellar granule cells .
9645956	0	NMDA	55,59	BDNF	0,4	NMDA	BDNF	CHEBI:6121	627	Chemical	Gene	receptor|compound|START_ENTITY phosphorylation|nmod|receptor subunit|nsubj|phosphorylation increases|xcomp|subunit increases|nsubj|END_ENTITY	BDNF acutely increases tyrosine phosphorylation of the NMDA receptor subunit 2B in cortical and hippocampal postsynaptic densities .
9674574	0	NMDA	82,86	BDNF	0,4	NMDA	BDNF	CHEBI:6121	24225(Tax:10116)	Chemical	Gene	transcripts|nmod|START_ENTITY transcripts|amod|END_ENTITY	BDNF gene transcripts in mesencephalic neurons and its differential regulation by NMDA .
19476549	0	NMDA	79,83	Bdnf	116,120	NMDA	Bdnf	D016202	24225(Tax:10116)	Chemical	Gene	activation|compound|START_ENTITY activation|nmod|promoter promoter|compound|END_ENTITY	Dynamic chromatin remodeling events in hippocampal neurons are associated with NMDA receptor-mediated activation of Bdnf gene promoter 1 .
19565326	0	NMDA	0,4	Bdnf	73,77	NMDA	Bdnf	CHEBI:6121	627	Chemical	Gene	activation|compound|START_ENTITY induces|nsubj|activation induces|dobj|modification modification|nmod|promoters promoters|compound|END_ENTITY	NMDA receptor activation induces differential epigenetic modification of Bdnf promoters in hippocampal neurons .
10212287	0	NMDA	72,76	Brain-derived_neurotrophic_factor	0,33	NMDA	Brain-derived neurotrophic factor	CHEBI:6121	627	Chemical	Gene	effect|nmod|START_ENTITY mediates|dobj|effect mediates|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor mediates the anti-apoptotic effect of NMDA in cerebellar granule neurons : signal transduction cascades and site of ethanol action .
12395101	0	NMDA	42,46	Brain-derived_neurotrophic_factor	0,33	NMDA	Brain-derived neurotrophic factor	CHEBI:6121	24225(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor induces NMDA receptor 1 phosphorylation in rat spinal cord .
17045972	0	NMDA	52,56	Brain-derived_neurotrophic_factor	0,33	NMDA	Brain-derived neurotrophic factor	CHEBI:6121	12064(Tax:10090)	Chemical	Gene	activity|compound|START_ENTITY increases|dobj|activity increases|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor rapidly increases NMDA receptor channel activity through Fyn-mediated phosphorylation .
10380851	0	NMDA	12,16	CA1	74,77	NMDA	CA1	CHEBI:6121	12346(Tax:10090)	Chemical	Gene	receptor-mediated|nsubj|START_ENTITY receptor-mediated|nmod|area area|compound|END_ENTITY	Facilitated NMDA receptor-mediated synaptic plasticity in the hippocampal CA1 area of dystrophin-deficient mice .
10562337	0	NMDA	51,55	CA1	73,76	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY sensitivity|nmod|receptors switch|nmod|sensitivity switch|nmod|cells cells|compound|END_ENTITY	Early postnatal switch in magnesium sensitivity of NMDA receptors in rat CA1 pyramidal cells .
10601432	0	NMDA	77,81	CA1	134,137	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	potentiation|compound|START_ENTITY potentiation|nmod|END_ENTITY	Evidence for involvement of group II/III metabotropic glutamate receptors in NMDA receptor-independent long-term potentiation in area CA1 of rat hippocampus .
10729331	0	NMDA	0,4	CA1	73,76	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	content|compound|START_ENTITY content|nmod|area area|compound|END_ENTITY	NMDA receptor content of synapses in stratum radiatum of the hippocampal CA1 area .
10777769	0	NMDA	66,70	CA1	104,107	NMDA	CA1	CHEBI:6121	759	Chemical	Gene	LTP|compound|START_ENTITY LTP|nmod|END_ENTITY	The extracellular_signal-regulated_kinase cascade is required for NMDA receptor-independent LTP in area CA1 but not area CA3 of the hippocampus .
10823575	0	NMDA	23,27	CA1	77,80	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	potentiation|compound|START_ENTITY potentiation|nmod|END_ENTITY	Hyperammonemia impairs NMDA receptor-dependent long-term potentiation in the CA1 of rat hippocampus in vitro .
10825494	0	NMDA	64,68	CA1	123,126	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	potentiation|nmod|START_ENTITY EPSP|nsubj|potentiation EPSP|nmod|slices slices|nummod|END_ENTITY	Afferent high strength tetanizations favour potentiation of the NMDA vs. AMPA receptor-mediated component of field EPSP in CA1 hippocampal slices of rats .
10844014	0	NMDA	105,109	CA1	3,6	NMDA	CA1	CHEBI:6121	759	Chemical	Gene	receptors|compound|START_ENTITY inactivation|nmod|receptors regulates|dobj|inactivation regulates|nmod|END_ENTITY	In CA1 pyramidal neurons of the hippocampus protein_kinase_C regulates calcium-dependent inactivation of NMDA receptors .
11164240	0	NMDA	90,94	CA1	51,54	NMDA	CA1	CHEBI:6121	759	Chemical	Gene	receptors|compound|START_ENTITY describes|nmod|receptors describes|nsubj|Modeling Modeling|nmod|potentials potentials|nmod|area area|compound|END_ENTITY	Modeling of evoked field potentials in hippocampal CA1 area describes their dependence on NMDA and GABA receptors .
11306194	0	NMDA	41,45	CA1	140,143	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	antagonist|compound|START_ENTITY effects|nmod|antagonist Characteristics|nmod|effects hippocampal|nsubj|Characteristics hippocampal|dobj|region region|compound|END_ENTITY	Characteristics of protective effects of NMDA antagonist and calcium channel antagonist on ischemic calcium accumulation in rat hippocampal CA1 region .
11517282	0	NMDA	56,60	CA1	81,84	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY increase|nmod|receptor binding|nsubj|increase binding|nmod|END_ENTITY	Acetylcholine mediates the estrogen-induced increase in NMDA receptor binding in CA1 of the hippocampus and the associated improvement in working memory .
11606620	0	NMDA	52,56	CA1	100,103	NMDA	CA1	CHEBI:6121	759	Chemical	Gene	receptors|compound|START_ENTITY activation|nmod|receptors limit|dobj|activation limit|nmod|spillover spillover|nmod|cells cells|nummod|END_ENTITY	Neuronal glutamate transporters limit activation of NMDA receptors by neurotransmitter spillover on CA1 pyramidal cells .
12106312	0	NMDA	29,33	CA1	115,118	NMDA	CA1	CHEBI:6121	100720116	Chemical	Gene	Channels|compound|START_ENTITY Contribution|nmod|Channels Contribution|nmod|Region Region|compound|END_ENTITY	The Relative Contribution of NMDA Receptor Channels in the Expression of Long-term Potentiation in the Hippocampal CA1 Region .
12106490	0	NMDA	132,136	CA1	31,34	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	Mediated|compound|START_ENTITY Mediated|nmod|Revealed Revealed|compound|END_ENTITY	Excitatory Connections Between CA1 Pyramidal Cells Revealed by Spike Triggered Averaging in Slices of Rat Hippocampus are Partially NMDA Receptor Mediated .
12201628	0	NMDA	72,76	CA1	104,107	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	activation|compound|START_ENTITY bursts|nmod|activation induces|dobj|bursts induces|nmod|neurons neurons|compound|END_ENTITY	Tetanic stimulation of schaffer collaterals induces rhythmic bursts via NMDA receptor activation in rat CA1 pyramidal neurons .
12211081	0	NMDA	24,28	CA1	69,72	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	zinc|nmod|START_ENTITY Augmentation|nmod|zinc responses|amod|Augmentation responses|nmod|END_ENTITY	Augmentation by zinc of NMDA receptor-mediated synaptic responses in CA1 of rat hippocampal slices : mediation by Src family tyrosine kinases .
12367605	0	NMDA	82,86	CA1	57,60	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	alters|dep|START_ENTITY alters|dep|excitability excitability|compound|END_ENTITY	Chronic benzodiazepine administration alters hippocampal CA1 neuron excitability : NMDA receptor function and expression -LRB- 1 -RRB- .
12611916	0	NMDA	31,35	CA1	61,64	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	function|compound|START_ENTITY function|nmod|cells cells|compound|END_ENTITY	D-Serine differently modulates NMDA receptor function in rat CA1 hippocampal pyramidal cells and interneurons .
12625465	0	NMDA	62,66	CA1	113,116	NMDA	CA1	CHEBI:6121	759	Chemical	Gene	induced|nmod|START_ENTITY bursts|acl|induced underlying|dobj|bursts mechanisms|acl|underlying microiontophoresis|nsubj|mechanisms microiontophoresis|nmod|dendrites dendrites|nmod|neurons neurons|nummod|END_ENTITY	Cellular mechanisms underlying the rhythmic bursts induced by NMDA microiontophoresis at the apical dendrites of CA1 pyramidal neurons .
12702709	0	NMDA	0,4	CA1	78,81	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY contribute|nsubj|receptors contribute|nmod|excitation excitation|nmod|interneurons interneurons|nummod|END_ENTITY	NMDA and AMPA receptors contribute to the nicotinic cholinergic excitation of CA1 interneurons in the rat hippocampus .
12845743	0	NMDA	34,38	CA1	85,88	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY lactone|nmod|receptor effect|nmod|lactone mediated|nsubj|effect mediated|nmod|neurons neurons|compound|END_ENTITY	The effect of coriaria lactone on NMDA receptor mediated currents in rat hippocampal CA1 neurons .
1297841	0	NMDA	55,59	CA1	67,70	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|neurones neurones|compound|END_ENTITY	Activation of protein_kinase_C suppresses responses to NMDA in rat CA1 hippocampal neurones .
1337105	0	NMDA	11,15	CA1	71,74	NMDA	CA1	CHEBI:6121	759	Chemical	Gene	model|nmod|START_ENTITY receptor-mediated|nsubj|model receptor-mediated|nmod|dendrites dendrites|nmod|neurons neurons|compound|END_ENTITY	A model of NMDA receptor-mediated activity in dendrites of hippocampal CA1 pyramidal neurons .
1356808	0	NMDA	0,4	CA1	57,60	NMDA	CA1	CHEBI:6121	759	Chemical	Gene	receptor-mediated|nsubj|START_ENTITY receptor-mediated|dobj|action action|nmod|proline proline|nmod|cells cells|nummod|END_ENTITY	NMDA receptor-mediated depolarizing action of proline on CA1 pyramidal cells .
14502288	0	NMDA	79,83	CA1	36,39	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY phosphorylating|dobj|receptors induces|advcl|phosphorylating induces|dobj|death death|compound|END_ENTITY	Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors .
14702333	0	NMDA	55,59	CA1	29,32	NMDA	CA1	CHEBI:6121	759	Chemical	Gene	receptor|nummod|START_ENTITY dependent|nmod:npmod|receptor dependent|nsubj|LTP LTP|nmod|region region|compound|END_ENTITY	Forskolin-induced LTP in the CA1 hippocampal region is NMDA receptor dependent .
14724233	0	NMDA	45,49	CA1	62,65	NMDA	CA1	CHEBI:6121	759	Chemical	Gene	currents|compound|START_ENTITY currents|nmod|END_ENTITY	Differential calcium-dependent modulation of NMDA currents in CA1 and CA3 hippocampal pyramidal cells .
15154678	0	NMDA	0,4	CA1	79,82	NMDA	CA1	CHEBI:6121	759	Chemical	Gene	receptor-mediated|nsubj|START_ENTITY receptor-mediated|dobj|after-potentials after-potentials|nmod|dendrites dendrites|nmod|neurons neurons|nummod|END_ENTITY	NMDA receptor-mediated depolarizing after-potentials in the basal dendrites of CA1 pyramidal neurons .
15155538	0	NMDA	77,81	CA1	104,107	NMDA	CA1	CHEBI:6121	759	Chemical	Gene	receptors|compound|START_ENTITY subtypes|nmod|receptors activate|dobj|subtypes activate|nmod|cell cell|compound|END_ENTITY	Schaffer collateral and perforant path inputs activate different subtypes of NMDA receptors on the same CA1 pyramidal cell .
15163674	0	NMDA	100,104	CA1	80,83	NMDA	CA1	CHEBI:6121	759	Chemical	Gene	response|compound|START_ENTITY brake|nmod|response Contribution|dep|brake Contribution|acl|synaptically synaptically|nmod|END_ENTITY	Contribution of Ih and GABAB to synaptically induced afterhyperpolarizations in CA1 : a brake on the NMDA response .
15190096	0	NMDA	55,59	CA1	102,105	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	afterdepolarization|compound|START_ENTITY development|nmod|afterdepolarization governs|dobj|development governs|nmod|neurons neurons|nummod|END_ENTITY	Slow afterhyperpolarization governs the development of NMDA receptor-dependent afterdepolarization in CA1 pyramidal neurons during synaptic stimulation .
15354184	0	NMDA	13,17	CA1	38,41	NMDA	CA1	CHEBI:6121	759	Chemical	Gene	current|compound|START_ENTITY current|nmod|neurons neurons|nummod|END_ENTITY	NAAG reduces NMDA receptor current in CA1 hippocampal pyramidal neurons of acute slices and dissociated neurons .
15447679	0	NMDA	0,4	CA1	131,134	NMDA	CA1	CHEBI:6121	12346(Tax:10090)	Chemical	Gene	results|compound|START_ENTITY phosphorylation|nsubj|results phosphorylation|nmod|END_ENTITY	NMDA receptor activation results in PKA - and ERK-dependent Mnk1 activation and increased eIF4E phosphorylation in hippocampal area CA1 .
15857673	0	NMDA	27,31	CA1	80,83	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	subunits|compound|START_ENTITY expression|nmod|subunits expression|nmod|gyrus gyrus|compound|END_ENTITY	Differential expression of NMDA receptor subunits and splice variants among the CA1 , CA3 and dentate gyrus of the adult rat .
15919065	0	NMDA	93,97	CA1	133,136	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	expression|compound|START_ENTITY expression|nmod|region region|compound|END_ENTITY	Chronic intermittent ethanol exposure enhances NMDA-receptor-mediated synaptic responses and NMDA receptor expression in hippocampal CA1 region .
15998281	0	NMDA	30,34	CA1	92,95	NMDA	CA1	CHEBI:6121	12346(Tax:10090)	Chemical	Gene	activation|compound|START_ENTITY required|nmod|activation required|nmod|END_ENTITY	NADPH oxidase is required for NMDA receptor-dependent activation of ERK in hippocampal area CA1 .
16339032	0	NMDA	14,18	CA1	82,85	NMDA	CA1	CHEBI:6121	12346(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|nmod|pituitary_adenylate_cyclase_activating_peptide pituitary_adenylate_cyclase_activating_peptide|nmod|neurons neurons|nummod|END_ENTITY	Modulation of NMDA receptors by pituitary_adenylate_cyclase_activating_peptide in CA1 neurons requires G_alpha_q , protein_kinase_C , and activation of Src .
16340465	0	NMDA	135,139	CA1	63,66	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	involvement|compound|START_ENTITY induced|dobj|involvement induced|dep|region region|dep|END_ENTITY	Ethanol exposure and withdrawal sensitizes the rat hippocampal CA1 pyramidal cell region to beta-amyloid -LRB- 25-35 -RRB- - induced cytotoxicity : NMDA receptor involvement .
16546126	0	NMDA	0,4	CA1	95,98	NMDA	CA1	CHEBI:6121	12346(Tax:10090)	Chemical	Gene	activation|compound|START_ENTITY induces|nsubj|activation induces|nmod|END_ENTITY	NMDA receptor activation induces translocation and activation of Rac in mouse hippocampal area CA1 .
16553775	0	NMDA	34,38	CA1	96,99	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	nicotine|nmod|START_ENTITY effects|nmod|nicotine receptor-mediated|nsubj|effects receptor-mediated|nmod|region region|compound|END_ENTITY	Reparatory effects of nicotine on NMDA receptor-mediated synaptic plasticity in the hippocampal CA1 region of chronically lead-exposed rats .
16770739	0	NMDA	66,70	CA1	97,100	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	blockade|compound|START_ENTITY blockade|nmod|END_ENTITY	Aversive learning under different training conditions : effects of NMDA receptor blockade in area CA1 of the hippocampus .
16895729	0	NMDA	162,166	CA1	113,116	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY phosphorylation|nmod|receptor prevents|nmod|phosphorylation prevents|dobj|impairment impairment|nmod|potentiation potentiation|nmod|END_ENTITY	Dehydroepiandrosterone_sulfate prevents ischemia-induced impairment of long-term potentiation in rat hippocampal CA1 by up-regulating tyrosine phosphorylation of NMDA receptor .
16904707	0	NMDA	47,51	CA1	84,87	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY roles|nmod|receptors roles|nmod|region region|compound|END_ENTITY	Differential roles of NR2A and NR2B-containing NMDA receptors in LTP and LTD in the CA1 region of two-week old rat hippocampus .
1704112	0	NMDA	61,65	CA1	111,114	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	sensitivity|appos|START_ENTITY sensitivity|nmod|END_ENTITY	Proteolytic enzymes do not destroy the N-methyl-D-aspartate -LRB- NMDA -RRB- sensitivity of acutely isolated hippocampal CA1 and CA3 neurons from postnatal rats .
17241157	0	NMDA	45,49	CA1	102,105	NMDA	CA1	CHEBI:6121	759	Chemical	Gene	reduced|iobj|START_ENTITY reduced|dobj|neurotransmission neurotransmission|nmod|area area|compound|END_ENTITY	Endogenous N-acetylaspartylglutamate reduced NMDA receptor-dependent current neurotransmission in the CA1 area of the hippocampus .
17329628	0	NMDA	26,30	CA1	88,91	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	shunting|nmod|START_ENTITY EPSP|nsubj|shunting EPSP|nmod|afterhyperpolarization afterhyperpolarization|nmod|neurons neurons|compound|END_ENTITY	Selective shunting of the NMDA EPSP component by the slow afterhyperpolarization in rat CA1 pyramidal neurons .
17445224	0	NMDA	11,15	CA1	39,42	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	activation|compound|START_ENTITY activation|nmod|area area|nummod|END_ENTITY	Deficit of NMDA receptor activation in CA1 hippocampal area of aged rats is rescued by D-cycloserine .
17626204	0	NMDA	50,54	CA1	89,92	NMDA	CA1	CHEBI:6121	12346(Tax:10090)	Chemical	Gene	responses|compound|START_ENTITY responses|nmod|neurons neurons|compound|END_ENTITY	Endogenous alkaline transients boost postsynaptic NMDA receptor responses in hippocampal CA1 pyramidal neurons .
18702724	0	NMDA	64,68	CA1	98,101	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY activation|nmod|receptors mediated|nmod|activation mediated|nmod|neurons neurons|compound|END_ENTITY	A plateau potential mediated by the activation of extrasynaptic NMDA receptors in rat hippocampal CA1 pyramidal neurons .
18762286	0	NMDA	30,34	CA1	65,68	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	function|compound|START_ENTITY function|nmod|cells cells|nummod|END_ENTITY	Integrin activation modulates NMDA and AMPA receptor function of CA1 cells in a dose-related fashion in vivo .
18826591	0	NMDA	78,82	CA1	164,167	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY involvement|nmod|receptors fear|nsubj|involvement fear|nmod|region region|compound|END_ENTITY	Induction - and conditioning-protocol dependent involvement of NR2B-containing NMDA receptors in synaptic potentiation and contextual fear memory in the hippocampal CA1 region of rats .
19038222	0	NMDA	44,48	CA1	123,126	NMDA	CA1	CHEBI:6121	759	Chemical	Gene	composition|compound|START_ENTITY bidirectional|nmod|composition bidirectional|nmod|neurons neurons|compound|END_ENTITY	Rapid , bidirectional remodeling of synaptic NMDA receptor subunit composition by A-type K + channel activity in hippocampal CA1 pyramidal neurons .
19077273	0	NMDA	89,93	CA1	107,110	NMDA	CA1	CHEBI:6121	759	Chemical	Gene	receptors|compound|START_ENTITY regulation|nmod|receptors cytoskeletal|dobj|regulation cytoskeletal|nmod|neurons neurons|nummod|END_ENTITY	Abelson tyrosine kinase links PDGFbeta receptor activation to cytoskeletal regulation of NMDA receptors in CA1 hippocampal neurons .
19490087	0	NMDA	16,20	CA1	86,89	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY required|nsubjpass|receptors required|nmod|region region|nummod|END_ENTITY	NR2A-containing NMDA receptors are required for L-LTP induction and depotentiation in CA1 region of hippocampal slices .
1972782	0	NMDA	13,17	CA1	72,75	NMDA	CA1	CHEBI:6121	759	Chemical	Gene	receptor-mediated|nsubj|START_ENTITY receptor-mediated|nmod|dendrites dendrites|compound|END_ENTITY	Postsynaptic NMDA receptor-mediated calcium accumulation in hippocampal CA1 pyramidal cell dendrites .
19795494	0	NMDA	20,24	CA1	98,101	NMDA	CA1	CHEBI:6121	12346(Tax:10090)	Chemical	Gene	subunits|compound|START_ENTITY levels|nmod|subunits levels|nmod|END_ENTITY	Increased levels of NMDA receptor NR2A subunits at pre - and postsynaptic sites of the hippocampal CA1 : an early response to conditional double knockout of presenilin_1_and_2 .
1981329	0	NMDA	41,45	CA1	73,76	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	EPSPs|compound|START_ENTITY EPSPs|nmod|cells cells|nummod|END_ENTITY	Dendritic action potentials activated by NMDA receptor-mediated EPSPs in CA1 hippocampal pyramidal cells .
20357110	0	NMDA	26,30	CA1	44,47	NMDA	CA1	CHEBI:6121	12346(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|nmod|hippocampus hippocampus|nummod|END_ENTITY	Loss of GluN2B-containing NMDA receptors in CA1 hippocampus and cortex impairs long-term depression , reduces dendritic spine density , and disrupts learning .
20441772	0	NMDA	70,74	CA1	114,117	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	subunit|compound|START_ENTITY phosphorylation|nmod|subunit phosphorylation|nmod|END_ENTITY	Oligomerized Abeta25-35 induces increased tyrosine phosphorylation of NMDA receptor subunit 2A in rat hippocampal CA1 subfield .
20525770	0	NMDA	61,65	CA1	131,134	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	receptor-dependent|compound|START_ENTITY receptor-dependent|appos|depression depression|nmod|END_ENTITY	Involvement of the metabotropic glutamate receptor mGluR5 in NMDA receptor-dependent , learning-facilitated long-term depression in CA1 synapses .
20569241	0	NMDA	63,67	CA1	134,137	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	associated|nmod|START_ENTITY associated|nmod|synapse synapse|compound|END_ENTITY	Reduction in glutamate uptake is associated with extrasynaptic NMDA and metabotropic glutamate receptor activation at the hippocampal CA1 synapse of aged rats .
20667449	0	NMDA	73,77	CA1	114,117	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	NR1|compound|START_ENTITY NR1|nmod|region region|compound|END_ENTITY	Metabotropic glutamate mGlu5 receptor-mediated serine phosphorylation of NMDA receptor subunit NR1 in hippocampal CA1 region after transient global ischemia in rats .
21355301	0	NMDA	41,45	CA1	74,77	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|nmod|region region|compound|END_ENTITY	-LSB- Effect of puerarin on the expression of NMDA receptor in the hippocampus CA1 region after focal cerebral_ischemia in rats -RSB- .
2149086	0	NMDA	58,62	CA1	76,79	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY increase|nmod|receptors increase|nmod|cells cells|nummod|END_ENTITY	Developmental increase in the sensitivity to magnesium of NMDA receptors on CA1 hippocampal pyramidal cells .
21955919	0	NMDA	36,40	CA1	92,95	NMDA	CA1	CHEBI:6121	12346(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|nmod|oriens oriens|nmod|END_ENTITY	D4 dopamine receptors modulate NR2B NMDA receptors and LTP in stratum oriens of hippocampal CA1 .
22419815	0	NMDA	0,4	CA1	18,21	NMDA	CA1	CHEBI:6121	759	Chemical	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	NMDA signaling in CA1 mediates selectively the spatial component of episodic memory .
23230236	0	NMDA	10,14	CA1	121,124	NMDA	CA1	D016202	310218(Tax:10116)	Chemical	Gene	subtypes|compound|START_ENTITY mediate|nsubj|subtypes mediate|nmod|synapses synapses|nummod|END_ENTITY	Different NMDA receptor subtypes mediate induction of long-term potentiation and two forms of short-term potentiation at CA1 synapses in rat hippocampus in vitro .
23270879	0	NMDA	28,32	CA1	74,77	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY Activation|nmod|receptors induces|nsubj|Activation induces|dobj|LTD LTD|nmod|neurons neurons|compound|END_ENTITY	Activation of extrasynaptic NMDA receptors induces LTD in rat hippocampal CA1 neurons .
23313317	0	NMDA	9,13	CA1	54,57	NMDA	CA1	CHEBI:6121	759	Chemical	Gene	LTP|compound|START_ENTITY LTP|nmod|area area|compound|END_ENTITY	Enhanced NMDA receptor-dependent LTP in the epileptic CA1 area via upregulation of NR2B .
23486587	0	NMDA	113,117	CA1	80,83	NMDA	CA1	CHEBI:6121	759	Chemical	Gene	receptors|compound|START_ENTITY activity|nmod|receptors depends|nmod|activity depends|nsubj|Induction Induction|nmod|expression expression|nmod|potentiation potentiation|nmod|field field|compound|END_ENTITY	Induction of S100B gene expression in long-term potentiation in the hippocampal CA1 field depends on activity of NMDA receptors .
23497405	0	NMDA	88,92	CA1	118,121	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY impairment_of_spatial_working_memory|nmod|receptors impairment_of_spatial_working_memory|nmod|region region|compound|END_ENTITY	Delay-dependent impairment_of_spatial_working_memory with inhibition of NR2B-containing NMDA receptors in hippocampal CA1 region of rats .
23711138	0	NMDA	16,20	CA1	68,71	NMDA	CA1	CHEBI:6121	759	Chemical	Gene	Potentiation|nmod|START_ENTITY receptors|nsubj|Potentiation receptors|nmod|neurons neurons|compound|END_ENTITY	Potentiation of NMDA receptors by Withania somnifera on hippocampal CA1 pyramidal neurons .
24303196	0	NMDA	82,86	CA1	50,53	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	Neurosteroidogenesis|compound|START_ENTITY involves|dobj|Neurosteroidogenesis involves|nsubj|induction induction|nmod|slices slices|nummod|END_ENTITY	Metaplastic LTP inhibition after LTD induction in CA1 hippocampal slices involves NMDA Receptor-mediated Neurosteroidogenesis .
24674276	0	NMDA	84,88	CA1	128,131	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	activation|compound|START_ENTITY activation|nmod|pyramidal_neurons pyramidal_neurons|compound|END_ENTITY	Intracellular calcium elevation during plateau potentials mediated by extrasynaptic NMDA receptor activation in rat hippocampal CA1 pyramidal_neurons is primarily due to calcium entry through voltage-gated calcium channels .
24719106	0	NMDA	11,15	CA1	114,117	NMDA	CA1	CHEBI:6121	12346(Tax:10090)	Chemical	Gene	signaling|compound|START_ENTITY required|nsubjpass|signaling required|nmod|induction induction|nmod|depression depression|nmod|region region|compound|END_ENTITY	Ionotropic NMDA receptor signaling is required for the induction of long-term depression in the mouse hippocampal CA1 region .
24929103	0	NMDA	37,41	CA1	137,140	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY activation|nmod|receptors activation|nmod|END_ENTITY	Involvement of P38MAPK activation by NMDA receptors and non-NMDA receptors in amyloid-b peptide-induced neuronal_loss in rat hippocampal CA1 and CA3 subfields .
25276438	0	NMDA	82,86	CA1	50,53	NMDA	CA1	CHEBI:6121	12346(Tax:10090)	Chemical	Gene	Receptors|compound|START_ENTITY END_ENTITY|nmod|Receptors	Abeta -LRB- 1-42 -RRB- Enhances Neuronal Excitability in the CA1 via NR2B Subunit-Containing NMDA Receptors .
25680309	0	NMDA	23,27	CA1	19,22	NMDA	CA1	CHEBI:6121	12346(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	The dual effect of CA1 NMDA receptor modulation on ACPA-induced amnesia in step-down passive avoidance learning task .
2569702	0	NMDA	20,24	CA1	54,57	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	responses|compound|START_ENTITY potentiates|dobj|responses potentiates|nmod|neurons neurons|compound|END_ENTITY	Glycine potentiates NMDA responses in rat hippocampal CA1 neurons .
2572247	0	NMDA	80,84	CA1	49,52	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	APV|compound|START_ENTITY blocked|nmod|APV blocked|nsubjpass|discharge discharge|nmod|neurones neurones|compound|END_ENTITY	Enflurane-induced burst discharge of hippocampal CA1 neurones is blocked by the NMDA receptor antagonist APV .
25791230	0	NMDA	100,104	CA1	65,68	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY regulated|nmod|receptors regulated|nsubjpass|strength strength|nmod|input input|nmod|region region|compound|END_ENTITY	Synaptic strength at the temporoammonic input to the hippocampal CA1 region in vivo is regulated by NMDA receptors , metabotropic glutamate receptors and voltage-gated calcium channels .
26100337	0	NMDA	110,114	CA1	56,59	NMDA	CA1	D016202	12346(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY population|nmod|receptors has|nmod|population has|nsubj|release release|nmod|collateral collateral|nmod|synapses synapses|nummod|END_ENTITY	Facilitated glutamate release at Schaffer collateral to CA1 synapses has access to an exclusive population of NMDA receptors .
26547631	0	NMDA	17,21	CA1	104,107	NMDA	CA1	D016202	310218(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|dep|mechanism mechanism|nmod|radiatum radiatum|compound|END_ENTITY	Tonically active NMDA receptors - a signalling mechanism critical for interneuronal excitability in the CA1 stratum radiatum .
26631168	0	NMDA	79,83	CA1	110,113	NMDA	CA1	D016202	12346(Tax:10090)	Chemical	Gene	LTP|compound|START_ENTITY LTP|nmod|neurons neurons|nummod|END_ENTITY	TRPM4-dependent post-synaptic depolarization is essential for the induction of NMDA receptor-dependent LTP in CA1 hippocampal neurons .
26762803	0	NMDA	89,93	CA1	62,65	NMDA	CA1	D016202	310218(Tax:10116)	Chemical	Gene	hippocampal|nmod|START_ENTITY hippocampal|nsubj|differences differences|nmod|modulation modulation|nmod|END_ENTITY	Major dorsoventral differences in the modulation of the local CA1 hippocampal network by NMDA , mGlu5 , adenosine A2A and cannabinoid CB1 receptors .
2899309	0	NMDA	0,4	CA1	70,73	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|dep|lack lack|nmod|effect effect|nmod|hypoxic_damage hypoxic_damage|nmod|region region|nummod|END_ENTITY	NMDA antagonists : lack of protective effect against hypoxic_damage in CA1 region of hippocampal slices .
7478182	0	NMDA	37,41	CA1	96,99	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|nmod|plasticity plasticity|nmod|area area|compound|END_ENTITY	Non-involvement of the redox site of NMDA receptors in bidirectional synaptic plasticity in the CA1 area of the rat hippocampus in vitro .
7551191	0	NMDA	51,55	CA1	135,138	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	depression|nmod|START_ENTITY expression|nmod|depression receptor-mediated|nsubj|expression receptor-mediated|nmod|area area|compound|END_ENTITY	Simultaneous expression of long-term depression of NMDA and long-term potentiation of AMPA receptor-mediated synaptic responses in the CA1 area of the kainic_acid-lesioned hippocampus .
7666170	0	NMDA	47,51	CA1	3,6	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY state|nmod|receptors determines|nsubj|state determines|nmod|neurons neurons|nummod|END_ENTITY	In CA1 hippocampal neurons , the redox state of NMDA receptors determines LTP expressed by NMDA but not by AMPA receptors .
7666170	0	NMDA	90,94	CA1	3,6	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	expressed|nmod|START_ENTITY determines|ccomp|expressed determines|nmod|neurons neurons|nummod|END_ENTITY	In CA1 hippocampal neurons , the redox state of NMDA receptors determines LTP expressed by NMDA but not by AMPA receptors .
7882020	0	NMDA	0,4	CA1	45,48	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	responses|compound|START_ENTITY responses|nmod|region region|compound|END_ENTITY	NMDA receptor responses in adult hippocampal CA1 region after neonatal treatment with MK-801 : comparison with NMDA receptor responses in the immature rat .
7882020	0	NMDA	110,114	CA1	45,48	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	responses|compound|START_ENTITY comparison|nmod|responses responses|dep|comparison responses|nmod|region region|compound|END_ENTITY	NMDA receptor responses in adult hippocampal CA1 region after neonatal treatment with MK-801 : comparison with NMDA receptor responses in the immature rat .
7907824	0	NMDA	14,18	CA1	49,52	NMDA	CA1	CHEBI:6121	759	Chemical	Gene	receptors|compound|START_ENTITY Activation|nmod|receptors END_ENTITY|nsubj|Activation	Activation of NMDA receptors in hippocampal area CA1 by low and high frequency orthodromic stimulation and their contribution to induction of long-term potentiation .
7907938	0	NMDA	123,127	CA1	55,58	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	activation|compound|START_ENTITY require|dobj|activation require|nsubj|enhancement enhancement|nmod|transmission transmission|nmod|END_ENTITY	Prolonged enhancement of synaptic transmission in area CA1 of rat hippocampal slices induced by NaF/AlCl3 does not require NMDA receptor activation but is suppressed by inhibitors of phosphoinositide-mediated signalling pathways .
8095836	0	NMDA	106,110	CA1	59,62	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	potential|compound|START_ENTITY modifications|nmod|potential induces|dobj|modifications induces|nsubj|Pairing Pairing|nmod|activities activities|nmod|neurons neurons|compound|END_ENTITY	Pairing of pre - and postsynaptic activities in hippocampal CA1 neurons induces long-term modifications of NMDA receptor-mediated synaptic potential .
8097032	0	NMDA	59,63	CA1	85,88	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	component|compound|START_ENTITY enhance|dobj|component enhance|nmod|neurons neurons|nummod|END_ENTITY	Glutamate and theta-rhythm stimulation selectively enhance NMDA component of EPSC in CA1 neurons of young rats .
8102941	0	NMDA	85,89	CA1	35,38	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY Blockade|nmod|receptors Blockade|nmod|cells cells|nummod|END_ENTITY	Blockade of antidromic invasion of CA1 pyramidal cells during synaptic activation of NMDA receptors .
8271224	0	NMDA	99,103	CA1	56,59	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY activation|nmod|receptors induced|nmod|activation induced|nmod|neurones neurones|compound|END_ENTITY	Characterization of Ca2 + signals induced in hippocampal CA1 neurones by the synaptic activation of NMDA receptors .
8294969	0	NMDA	19,23	CA1	72,75	NMDA	CA1	CHEBI:6121	759	Chemical	Gene	currents|compound|START_ENTITY LTP|nmod|currents induced|nsubj|LTP induced|nmod|anoxia anoxia|nmod|neurons neurons|nummod|END_ENTITY	A selective LTP of NMDA receptor-mediated currents induced by anoxia in CA1 hippocampal neurons .
8937729	0	NMDA	0,4	CA1	85,88	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	dependence|compound|START_ENTITY dependence|nmod|depression depression|nmod|transmission transmission|nmod|region region|compound|END_ENTITY	NMDA receptor dependence of mGlu-mediated depression of synaptic transmission in the CA1 region of the rat hippocampus .
8980238	0	NMDA	38,42	CA1	34,37	NMDA	CA1	CHEBI:6121	12346(Tax:10090)	Chemical	Gene	plasticity|compound|START_ENTITY plasticity|compound|END_ENTITY	The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory .
8981446	0	NMDA	0,4	CA1	40,43	NMDA	CA1	CHEBI:6121	759	Chemical	Gene	synapses|compound|START_ENTITY synapses|nmod|neurones neurones|nummod|END_ENTITY	NMDA receptor-mediated synapses between CA1 neurones : activation by ischaemia .
9030643	0	NMDA	74,78	CA1	51,54	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	input|compound|START_ENTITY increases|nmod|input increases|dobj|sensitivity sensitivity|nmod|cells cells|compound|END_ENTITY	Estradiol increases the sensitivity of hippocampal CA1 pyramidal cells to NMDA receptor-mediated synaptic input : correlation with dendritic spine density .
9089498	0	NMDA	83,87	CA1	120,123	NMDA	CA1	CHEBI:6121	759	Chemical	Gene	EPSCs|compound|START_ENTITY EPSCs|nmod|END_ENTITY	Evidence that presynaptic changes are involved in the expression of LTP and LTD of NMDA receptor-mediated EPSCs in area CA1 of the hippocampus .
9098684	0	NMDA	55,59	CA1	78,81	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|nmod|END_ENTITY	DCG-IV inhibits synaptic transmission by activation of NMDA receptors in area CA1 of rat hippocampus .
9106465	0	NMDA	0,4	CA1	96,99	NMDA	CA1	CHEBI:6121	759	Chemical	Gene	dependence|compound|START_ENTITY dependence|nmod|region region|compound|END_ENTITY	NMDA receptor dependence of the input specific NMDA receptor-independent LTP in the hippocampal CA1 region .
9106465	0	NMDA	47,51	CA1	96,99	NMDA	CA1	CHEBI:6121	759	Chemical	Gene	LTP|compound|START_ENTITY dependence|nmod|LTP dependence|nmod|region region|compound|END_ENTITY	NMDA receptor dependence of the input specific NMDA receptor-independent LTP in the hippocampal CA1 region .
9106737	0	NMDA	20,24	CA1	67,70	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	knockouts|compound|START_ENTITY hippocampal|nsubj|knockouts hippocampal|dobj|region region|compound|END_ENTITY	Adenovirus-mediated NMDA receptor knockouts in the rat hippocampal CA1 region .
9365912	0	NMDA	14,18	CA1	106,109	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY Activation|nmod|receptors necessary|nsubj|Activation necessary|nmod|induction induction|nmod|potentiation potentiation|nmod|END_ENTITY	Activation of NMDA receptors is necessary for the induction of associative long-term potentiation in area CA1 of the rat hippocampal slice .
9390781	0	NMDA	0,4	CA1	85,88	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	activation|compound|START_ENTITY activation|dep|investigations investigations|nmod|area area|compound|END_ENTITY	NMDA receptor activation in the aged rat : electrophysiological investigations in the CA1 area of the hippocampal slice ex vivo .
9527618	0	NMDA	18,22	CA1	58,61	NMDA	CA1	CHEBI:6121	759	Chemical	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Cyclic changes in NMDA receptor activation in hippocampal CA1 neurons after ischemia .
9663507	0	NMDA	42,46	CA1	81,84	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	complexes|compound|START_ENTITY expression|nmod|complexes persist|nsubj|expression persist|nmod|END_ENTITY	Decreased expression and functionality of NMDA receptor complexes persist in the CA1 , but not in the dentate gyrus after transient cerebral_ischemia .
9729327	0	NMDA	15,19	CA1	126,129	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY Involvement|nmod|receptors Involvement|nmod|potentiation potentiation|nmod|area area|compound|END_ENTITY	Involvement of NMDA receptors and voltage-dependent calcium channels on augmentation of long-term potentiation in hippocampal CA1 area of morphine dependent rats .
9744422	0	NMDA	0,4	CA1	66,69	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	LTP|compound|START_ENTITY LTP|nmod|basal basal|nmod|dendrites dendrites|nmod|cells cells|nummod|END_ENTITY	NMDA receptor-independent LTP in basal versus apical dendrites of CA1 pyramidal cells in rat hippocampal slice .
9753587	0	NMDA	0,4	CA1	111,114	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	glutamate|nsubj|START_ENTITY glutamate|dobj|forms forms|nmod|coexist coexist|nmod|cells cells|nummod|END_ENTITY	NMDA receptor-dependent and metabotropic glutamate receptor-dependent forms of long-term depression coexist in CA1 hippocampal pyramidal cells .
9882020	0	NMDA	14,18	CA1	59,62	NMDA	CA1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	Alteration|nmod|START_ENTITY receptor-mediated|nsubj|Alteration receptor-mediated|nmod|area area|nummod|END_ENTITY	Alteration of NMDA receptor-mediated synaptic responses in CA1 area of the aged rat hippocampus : contribution of GABAergic and cholinergic deficits .
10727704	0	NMDA	28,32	CA3	72,75	NMDA	CA3	CHEBI:6121	12350(Tax:10090)	Chemical	Gene	subtypes|compound|START_ENTITY targeting|nmod|subtypes hippocampal|nsubj|targeting hippocampal|dobj|synapses synapses|nummod|END_ENTITY	Input-specific targeting of NMDA receptor subtypes at mouse hippocampal CA3 pyramidal neuron synapses .
10758091	0	NMDA	99,103	CA3	81,84	NMDA	CA3	CHEBI:6121	54232(Tax:10116)	Chemical	Gene	mechanism|compound|START_ENTITY region|nmod|mechanism region|compound|END_ENTITY	Adenosine receptor antagonists induce persistent bursting in the rat hippocampal CA3 region via an NMDA receptor-dependent mechanism .
11241388	0	NMDA	77,81	CA3	102,105	NMDA	CA3	CHEBI:6121	54232(Tax:10116)	Chemical	Gene	correlates|appos|START_ENTITY correlates|dep|levels levels|nmod|neurons neurons|nummod|END_ENTITY	Hippocampal dependent learning ability correlates with N-methyl-D-aspartate -LRB- NMDA -RRB- receptor levels in CA3 neurons of young and aged rats .
12040087	0	NMDA	32,36	CA3	28,31	NMDA	CA3	CHEBI:6121	12350(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Requirement for hippocampal CA3 NMDA receptors in associative memory recall .
12718863	0	NMDA	16,20	CA3	12,15	NMDA	CA3	CHEBI:6121	761	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Hippocampal CA3 NMDA receptors are crucial for memory acquisition of one-time experience .
1323387	0	NMDA	60,64	CA3	85,88	NMDA	CA3	CHEBI:6121	54232(Tax:10116)	Chemical	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	Sigma ligands and neuropeptide Y selectively potentiate the NMDA response in the rat CA3 dorsal hippocampus : in vivo electrophysiological studies .
1374464	0	NMDA	68,72	CA3	33,36	NMDA	CA3	CHEBI:6121	54232(Tax:10116)	Chemical	Gene	enhances|nmod|START_ENTITY enhances|dobj|sensitivity sensitivity|nmod|cells cells|nummod|END_ENTITY	Kindling enhances sensitivity of CA3 hippocampal pyramidal cells to NMDA .
15993905	0	NMDA	40,44	CA3	58,61	NMDA	CA3	CHEBI:6121	761	Chemical	Gene	responses|compound|START_ENTITY reduces|dobj|responses reduces|nmod|cells cells|nummod|END_ENTITY	Muscarinic receptor stimulation reduces NMDA responses in CA3 hippocampal pyramidal cells via Ca2 + - dependent activation of tyrosine phosphatase .
1608537	0	NMDA	30,34	CA3	51,54	NMDA	CA3	CHEBI:6121	761	Chemical	Gene	conductances|compound|START_ENTITY alter|dobj|conductances alter|nmod|neurons neurons|nummod|END_ENTITY	Neuropeptide Y does not alter NMDA conductances in CA3 pyramidal neurons : a slice-patch study .
16421310	0	NMDA	28,32	CA3	12,15	NMDA	CA3	CHEBI:6121	761	Chemical	Gene	receptors|compound|START_ENTITY receptors|nummod|END_ENTITY	The role of CA3 hippocampal NMDA receptors in paired associate learning .
17004940	0	NMDA	4,8	CA3	0,3	NMDA	CA3	D016202	12350(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	CA3 NMDA receptors are crucial for rapid and automatic representation of context memory .
17607765	0	NMDA	4,8	CA3	0,3	NMDA	CA3	CHEBI:6121	12350(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	CA3 NMDA receptors are required for experience-dependent shifts in hippocampal activity .
17728388	0	NMDA	0,4	CA3	76,79	NMDA	CA3	CHEBI:6121	761	Chemical	Gene	trafficking|compound|START_ENTITY stabilizes|nsubj|trafficking stabilizes|dobj|state state|nmod|network network|compound|END_ENTITY	NMDA receptor trafficking at recurrent synapses stabilizes the state of the CA3 network .
19142228	0	NMDA	12,16	CA3	68,71	NMDA	CA3	CHEBI:6121	12350(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY Ablation|nmod|receptors enhances|nsubj|Ablation enhances|dobj|excitability excitability|nmod|neurons neurons|compound|END_ENTITY	Ablation of NMDA receptors enhances the excitability of hippocampal CA3 neurons .
19470655	0	NMDA	48,52	CA3	44,47	NMDA	CA3	CHEBI:6121	12350(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Pharmacological intervention of hippocampal CA3 NMDA receptors impairs acquisition and long-term memory retrieval of spatial pattern completion task .
1963738	0	NMDA	92,96	CA3	46,49	NMDA	CA3	CHEBI:6121	54232(Tax:10116)	Chemical	Gene	modulation|nmod|START_ENTITY vitro|dep|modulation receptors|amod|vitro mediated|nmod|receptors mediated|nmod|neurons neurons|compound|END_ENTITY	GABA mediated synaptic events in neonatal rat CA3 pyramidal neurons in vitro : modulation by NMDA and non-NMDA receptors .
19650121	0	NMDA	4,8	CA3	0,3	NMDA	CA3	CHEBI:6121	12350(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	CA3 NMDA receptors are required for the rapid formation of a salient contextual representation .
19726645	0	NMDA	0,4	CA3	164,167	NMDA	CA3	CHEBI:6121	12350(Tax:10090)	Chemical	Gene	GluN2B|compound|START_ENTITY crucial|nsubj|GluN2B crucial|nmod|synapses synapses|compound|END_ENTITY	NMDA receptor GluN2B -LRB- GluR_epsilon_2 / NR2B -RRB- subunit is crucial for channel function , postsynaptic macromolecular organization , and actin cytoskeleton at hippocampal CA3 synapses .
1981640	0	NMDA	38,42	CA3	55,58	NMDA	CA3	CHEBI:6121	761	Chemical	Gene	triggered|nmod|START_ENTITY triggered|nmod|neurones neurones|compound|END_ENTITY	Periodic inward currents triggered by NMDA in immature CA3 hippocampal neurones .
21108993	0	NMDA	69,73	CA3	65,68	NMDA	CA3	CHEBI:6121	12350(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Chronic stress-induced hippocampal dendritic_retraction requires CA3 NMDA receptors .
23852115	0	NMDA	14,18	CA3	48,51	NMDA	CA3	CHEBI:6121	54232(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY controls|nsubj|receptor controls|dobj|output output|nummod|END_ENTITY	Bidirectional NMDA receptor plasticity controls CA3 output and heterosynaptic metaplasticity .
25585032	2	NMDA	382,386	CA3	352,355	NMDA	CA3	D016202	761	Chemical	Gene	signaling|compound|START_ENTITY consistent|nmod|signaling END_ENTITY|amod|consistent	Based on an a priori model of hippocampal_dysfunction in schizophrenic_psychosis , the authors postulated molecular and cellular changes in CA3 consistent with increased NMDA receptor signaling .
7916046	0	NMDA	33,37	CA3	88,91	NMDA	CA3	CHEBI:6121	100306971(Tax:10141)	Chemical	Gene	currents|compound|START_ENTITY currents|acl|guinea_pig guinea_pig|dobj|cells cells|nummod|END_ENTITY	Kappa 2 opioid receptors inhibit NMDA receptor-mediated synaptic currents in guinea_pig CA3 pyramidal cells .
8027771	0	NMDA	70,74	CA3	107,110	NMDA	CA3	CHEBI:6121	761	Chemical	Gene	receptors|compound|START_ENTITY population|nmod|receptors expression|nmod|population induces|dobj|expression induces|nmod|END_ENTITY	Kindling induces the long-lasting expression of a novel population of NMDA receptors in hippocampal region CA3 .
8035900	0	NMDA	79,83	CA3	32,35	NMDA	CA3	CHEBI:6121	761	Chemical	Gene	antagonists|compound|START_ENTITY reduces|nmod|antagonists reduces|dobj|sensitivity sensitivity|nmod|cells cells|nummod|END_ENTITY	Kindling reduces sensitivity of CA3 hippocampal pyramidal cells to competitive NMDA receptor antagonists .
8642409	0	NMDA	33,37	CA3	90,93	NMDA	CA3	CHEBI:6121	54232(Tax:10116)	Chemical	Gene	potentiation|compound|START_ENTITY potentiation|nmod|END_ENTITY	Actions of endogenous opioids on NMDA receptor-independent long-term potentiation in area CA3 of the hippocampus .
9749710	0	NMDA	22,26	CA3	131,134	NMDA	CA3	CHEBI:6121	12350(Tax:10090)	Chemical	Gene	subunits|compound|START_ENTITY subunits|nmod|lucidum lucidum|nmod|END_ENTITY	Selective scarcity of NMDA receptor channel subunits in the stratum lucidum -LRB- mossy fibre-recipient layer -RRB- of the mouse hippocampal CA3 subfield .
20064573	0	NMDA	68,72	CAPON	59,64	NMDA	CAPON	CHEBI:6121	192363(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	Inhibition of nitric_oxide-induced nuclear localization of CAPON by NMDA receptor antagonist in cultured rat primary astrocytes .
24259588	0	NMDA	73,77	CD3	40,43	NMDA	CD3	CHEBI:6121	12501(Tax:10090)	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	Impaired_spatial_memory in mice lacking CD3 is associated with altered NMDA and AMPA receptors signaling independent of T-cell_deficiency .
12445470	0	NMDA	26,30	CREB	46,50	NMDA	CREB	CHEBI:6121	1385	Chemical	Gene	receptors|compound|START_ENTITY receptors|nmod|pathway pathway|compound|END_ENTITY	Coupling of extrasynaptic NMDA receptors to a CREB shut-off pathway is developmentally regulated .
12895416	0	NMDA	74,78	CRF_receptor_2	93,107	NMDA	CRF receptor 2	CHEBI:6121	1395	Chemical	Gene	receptors|compound|START_ENTITY receptors|nmod|END_ENTITY	Corticotropin-releasing_factor requires CRF_binding_protein to potentiate NMDA receptors via CRF_receptor_2 in dopamine neurons .
10102820	0	NMDA	83,87	CaMKII	19,25	NMDA	CaMKII	CHEBI:6121	818	Chemical	Gene	stimulation|compound|START_ENTITY control|nmod|stimulation control|nmod|translocation translocation|compound|END_ENTITY	Dynamic control of CaMKII translocation and localization in hippocampal neurons by NMDA receptor stimulation .
11459059	0	NMDA	21,25	CaMKII	41,47	NMDA	CaMKII	CHEBI:6121	818	Chemical	Gene	receptor|compound|START_ENTITY Interaction|nmod|receptor locks|nsubj|Interaction locks|dobj|END_ENTITY	Interaction with the NMDA receptor locks CaMKII in an active conformation .
12147342	0	NMDA	55,59	CaMKII	119,125	NMDA	CaMKII	CHEBI:6121	818	Chemical	Gene	subunits|nmod|START_ENTITY determinants|nmod|subunits receptor|nsubj|determinants receptor|nmod|END_ENTITY	Sequence determinants on the NR2A and NR2B subunits of NMDA receptor responsible for specificity of phosphorylation by CaMKII .
16242409	0	NMDA	0,4	CaMKII	88,94	NMDA	CaMKII	CHEBI:6121	818	Chemical	Gene	composition|compound|START_ENTITY controls|nsubj|composition controls|advcl|regulating regulating|xcomp|binding binding|nmod|END_ENTITY	NMDA receptor subunit composition controls synaptic plasticity by regulating binding to CaMKII .
17124502	0	NMDA	36,40	CaMKII	0,6	NMDA	CaMKII	CHEBI:6121	818	Chemical	Gene	Ca2|compound|START_ENTITY signaling|nsubj|Ca2 requires|xcomp|signaling requires|nsubj|translocation translocation|compound|END_ENTITY	CaMKII translocation requires local NMDA receptor-mediated Ca2 + signaling .
17602661	0	NMDA	39,43	CaMKII	95,101	NMDA	CaMKII	CHEBI:6121	818	Chemical	Gene	domain|compound|START_ENTITY alpha-actinin|nmod|domain Displacement|nmod|alpha-actinin promotes|nsubj|Displacement promotes|xcomp|binding binding|nsubj|END_ENTITY	Displacement of alpha-actinin from the NMDA receptor NR1 C0 domain By Ca2 + / calmodulin promotes CaMKII binding .
20643921	0	NMDA	0,4	CaMKII	59,65	NMDA	CaMKII	CHEBI:6121	818	Chemical	Gene	internalization|compound|START_ENTITY internalization|nmod|phosphorylation phosphorylation|compound|END_ENTITY	NMDA receptor-dependent GABAB receptor internalization via CaMKII phosphorylation of serine 867 in GABAB1 .
21606495	0	NMDA	48,52	CaMKII	148,154	NMDA	CaMKII	CHEBI:6121	818	Chemical	Gene	N-methyl-D-aspartate|dep|START_ENTITY trafficking|amod|N-methyl-D-aspartate promotes|dobj|trafficking promotes|advcl|triggering triggering|dobj|autophosphorylation autophosphorylation|appos|END_ENTITY	Protein_kinase_C promotes N-methyl-D-aspartate -LRB- NMDA -RRB- receptor trafficking by indirectly triggering calcium/calmodulin-dependent _ protein_kinase_II -LRB- CaMKII -RRB- autophosphorylation .
21768120	0	NMDA	148,152	CaMKII	103,109	NMDA	CaMKII	CHEBI:6121	818	Chemical	Gene	receptor|appos|START_ENTITY binding|nmod|receptor II|amod|binding II|appos|END_ENTITY	Nucleotides and phosphorylation bi-directionally modulate Ca2 + / calmodulin-dependent protein kinase II -LRB- CaMKII -RRB- binding to the N-methyl-D-aspartate -LRB- NMDA -RRB- receptor subunit GluN2B .
23478024	0	NMDA	72,76	CaMKII	10,16	NMDA	CaMKII	CHEBI:6121	818	Chemical	Gene	receptors|compound|START_ENTITY control|dobj|receptors kinase|advcl|control couples|ccomp|kinase couples|nsubj|END_ENTITY	Activated CaMKII couples GluN2B and casein kinase 2 to control synaptic NMDA receptors .
24655517	0	NMDA	56,60	CaMKII	29,35	NMDA	CaMKII	CHEBI:6121	818	Chemical	Gene	peptide|compound|START_ENTITY switch|nmod|peptide switch|nsubj|reconstitution reconstitution|nmod|memory memory|compound|END_ENTITY	In vitro reconstitution of a CaMKII memory switch by an NMDA receptor-derived peptide .
24734203	0	NMDA	73,77	CaMKII	177,183	NMDA	CaMKII	CHEBI:6121	818	Chemical	Gene	receptor|compound|START_ENTITY mediated|nsubj|receptor mediated|advcl|promoting promoting|dobj|interaction interaction|nmod|receptors receptors|compound|END_ENTITY	Active calcium/calmodulin-dependent _ protein_kinase_II -LRB- CaMKII -RRB- regulates NMDA receptor mediated postischemic long-term potentiation -LRB- i-LTP -RRB- by promoting the interaction between CaMKII and NMDA receptors in ischemia .
24734203	0	NMDA	73,77	CaMKII	55,61	NMDA	CaMKII	CHEBI:6121	818	Chemical	Gene	receptor|compound|START_ENTITY mediated|nsubj|receptor regulates|ccomp|mediated regulates|nsubj|protein_kinase_II protein_kinase_II|appos|END_ENTITY	Active calcium/calmodulin-dependent _ protein_kinase_II -LRB- CaMKII -RRB- regulates NMDA receptor mediated postischemic long-term potentiation -LRB- i-LTP -RRB- by promoting the interaction between CaMKII and NMDA receptors in ischemia .
26116817	0	NMDA	101,105	CaMKII	72,78	NMDA	CaMKII	D016202	818	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Interferon-b1a modulates glutamate neurotransmission in the CNS through CaMKII and GluN2A-containing NMDA receptors .
20698836	0	NMDA	27,31	DJ-1	53,57	NMDA	DJ-1	CHEBI:6121	11315	Chemical	Gene	receptor|compound|START_ENTITY regulation|nmod|receptor function|nsubj|regulation function|nmod|END_ENTITY	Differential regulation of NMDA receptor function by DJ-1 and PINK1 .
14622581	0	NMDA	4,8	ERK	36,39	NMDA	ERK	CHEBI:6121	5594	Chemical	Gene	receptor|compound|START_ENTITY coupled|nsubjpass|receptor coupled|nmod|pathway pathway|compound|END_ENTITY	The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1 .
15379998	0	NMDA	42,46	ERK	88,91	NMDA	ERK	CHEBI:6121	24338(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY subunit|nsubj|receptor subunit|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Brain-derived_neurotrophic_factor induces NMDA receptor subunit one phosphorylation via ERK and PKC in the rat spinal cord .
15998281	0	NMDA	30,34	ERK	68,71	NMDA	ERK	CHEBI:6121	26413(Tax:10090)	Chemical	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	NADPH oxidase is required for NMDA receptor-dependent activation of ERK in hippocampal area CA1 .
17205142	0	NMDA	0,4	ERK	58,61	NMDA	ERK	CHEBI:6121	5594	Chemical	Gene	converge|nsubj|START_ENTITY converge|xcomp|induce induce|dobj|depression depression|compound|END_ENTITY	NMDA and dopamine converge on the NMDA-receptor to induce ERK activation and synaptic depression in mature hippocampus .
17972914	0	NMDA	46,50	ERK	0,3	NMDA	ERK	CHEBI:6121	13844(Tax:10090)	Chemical	Gene	activity|compound|START_ENTITY stimulating|dobj|activity causes|advcl|stimulating causes|nsubj|activation activation|compound|END_ENTITY	ERK activation causes epilepsy by stimulating NMDA receptor activity .
19601643	0	NMDA	136,140	ERK	184,187	NMDA	ERK	CHEBI:6121	26413(Tax:10090)	Chemical	Gene	antagonism|compound|START_ENTITY antagonism|nmod|stimulation stimulation|nmod|cascade cascade|compound|END_ENTITY	4 ' - Demethylnobiletin , a bioactive metabolite of nobiletin enhancing PKA/ERK/CREB signaling , rescues learning_impairment associated with NMDA receptor antagonism via stimulation of the ERK cascade .
20595030	0	NMDA	88,92	ERK	71,74	NMDA	ERK	CHEBI:6121	24338(Tax:10116)	Chemical	Gene	pathways|nmod|START_ENTITY receptors|amod|pathways receptors|compound|END_ENTITY	Cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- peptide activates ERK pathways via NMDA receptors in rat spinal cord dorsal horn in an age-dependent manner .
22001931	0	NMDA	22,26	ERK	15,18	NMDA	ERK	CHEBI:6121	26413(Tax:10090)	Chemical	Gene	neurotoxicity|compound|START_ENTITY Involvement|nmod|neurotoxicity Involvement|nmod|END_ENTITY	Involvement of ERK in NMDA receptor-independent cortical neurotoxicity of hydrogen_sulfide .
24597568	0	NMDA	19,23	ERK	159,162	NMDA	ERK	D016202	24338(Tax:10116)	Chemical	Gene	blockade|compound|START_ENTITY impairs|nsubj|blockade impairs|advcl|suppressing suppressing|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Dorsal hippocampal NMDA receptor blockade impairs extinction of naloxone-precipitated conditioned place aversion in acute morphine-treated rats by suppressing ERK and CREB phosphorylation in the basolateral amygdala .
25322796	0	NMDA	70,74	ERK	22,25	NMDA	ERK	CHEBI:6121	24338(Tax:10116)	Chemical	Gene	activation|compound|START_ENTITY requires|dobj|activation requires|nsubj|END_ENTITY	Appetitive cue-evoked ERK signaling in the nucleus accumbens requires NMDA and D1 dopamine receptor activation and regulates CREB phosphorylation .
17722069	5	NMDA	728,732	ERK1/2	763,769	NMDA	ERK1/2	CHEBI:6121	26417;26413	Chemical	Gene	intravitreally|compound|START_ENTITY hr|nmod|intravitreally observed|nmod|hr observed|nsubjpass|activation activation|nmod|END_ENTITY	Within 1 hr after injecting NMDA intravitreally , activation of ERK1/2 and c-Fos induction were observed in retinal M ller cells .
18573356	0	NMDA	0,4	ERK1/2	76,82	NMDA	ERK1/2	CHEBI:6121	50689;116590	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	NMDA enhances stretching-induced differentiation of osteoblasts through the ERK1/2 signaling pathway .
20160127	0	NMDA	93,97	ERK1/2	116,122	NMDA	ERK1/2	CHEBI:6121	5595;5594	Chemical	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Glucocorticoid rapidly enhances NMDA-evoked neurotoxicity by attenuating the NR2A-containing NMDA receptor-mediated ERK1/2 activation .
21474451	0	NMDA	183,187	ERK1/2	94,100	NMDA	ERK1/2	CHEBI:6121	50689;116590	Chemical	Gene	neurotoxicity|compound|START_ENTITY changes|nmod|neurotoxicity leads|nmod|changes leads|csubj|Switching Switching|nmod|protein protein|nummod|END_ENTITY	Switching of N-methyl-D-aspartate -LRB- NMDA -RRB- receptor-favorite intracellular signal pathways from ERK1/2 protein to p38 mitogen-activated protein kinase leads to developmental changes in NMDA neurotoxicity .
21474451	0	NMDA	35,39	ERK1/2	94,100	NMDA	ERK1/2	CHEBI:6121	50689;116590	Chemical	Gene	pathways|appos|START_ENTITY Switching|nmod|pathways Switching|nmod|protein protein|nummod|END_ENTITY	Switching of N-methyl-D-aspartate -LRB- NMDA -RRB- receptor-favorite intracellular signal pathways from ERK1/2 protein to p38 mitogen-activated protein kinase leads to developmental changes in NMDA neurotoxicity .
25421211	0	NMDA	31,35	ERK1/2	108,114	NMDA	ERK1/2	D016202	5595;5594	Chemical	Gene	Receptors|compound|START_ENTITY Determine|nsubj|Receptors Determine|xcomp|Neurotoxicity Neurotoxicity|dep|Signaling Signaling|compound|END_ENTITY	Location - and Subunit-Specific NMDA Receptors Determine the Developmental Sevoflurane Neurotoxicity Through ERK1/2 Signaling .
11902114	0	NMDA	55,59	Erk1/2	95,101	NMDA	Erk1/2	CHEBI:6121	5595;5594	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Phosphatidylinositol 3-kinase is a central mediator of NMDA receptor signalling to MAP kinase -LRB- Erk1/2 -RRB- , Akt/PKB and CREB in striatal neurones .
16190898	0	NMDA	39,43	Fyn	0,3	NMDA	Fyn	CHEBI:6121	14360(Tax:10090)	Chemical	Gene	subunit|compound|START_ENTITY phosphorylation|nmod|subunit phosphorylation|compound|END_ENTITY	Fyn kinase-mediated phosphorylation of NMDA receptor NR2B subunit at Tyr1472 is essential for maintenance of neuropathic_pain .
10512978	0	NMDA	102,106	GAP-43	83,89	NMDA	GAP-43	CHEBI:6121	14432(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY gene|nmod|receptor gene|compound|END_ENTITY	Activity-dependent regulation of axonal growth : posttranscriptional control of the GAP-43 gene by the NMDA receptor in developing hippocampus .
16235228	3	NMDA	912,916	GFAP	1028,1032	NMDA	GFAP	CHEBI:6121	14580(Tax:10090)	Chemical	Gene	antagonists|compound|START_ENTITY suppress|nsubj|antagonists suppress|dobj|activation activation|acl|detected detected|dep|END_ENTITY	Furthermore , we investigated whether NR2B subunit-containing NMDA receptor antagonists could suppress the astrocytic activation , as detected by glial_fibrillary_acidic_protein -LRB- GFAP ; as a specific marker of astrocyte -RRB- - like immunoreactivities in mouse cortical astrocytes .
26081945	0	NMDA	28,32	GFAP	0,4	NMDA	GFAP	D016202	2670	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	GFAP and antibodies against NMDA receptor subunit NR2 as biomarkers for acute_cerebrovascular_diseases .
9100675	0	NMDA	11,15	GLT1	72,76	NMDA	GLT1	CHEBI:6121	6506	Chemical	Gene	subunit|compound|START_ENTITY subunit|appos|END_ENTITY	Changes of NMDA receptor subunit -LRB- NR1 , NR2B -RRB- and glutamate transporter -LRB- GLT1 -RRB- mRNA expression in Huntington 's _ disease -- an in situ hybridization study .
24556017	0	NMDA	82,86	GLUN2C	104,110	NMDA	GLUN2C	CHEBI:6121	14813(Tax:10090)	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Corticosterone treatment during adolescence induces down-regulation of reelin and NMDA receptor subunit GLUN2C expression only in male mice : implications for schizophrenia .
8954122	0	NMDA	0,4	GP120	29,34	NMDA	GP120	CHEBI:6121	155971(Tax:11676)	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	NMDA and HIV-1 coat protein , GP120 , produce necrotic but not apoptotic cell death in human CHP100_neuroblastoma cultures via a mechanism involving calpain .
11807413	0	NMDA	25,29	GRIN2B	51,57	NMDA	GRIN2B	CHEBI:6121	2904	Chemical	Gene	receptor|compound|START_ENTITY analysis|nmod|receptor subunit|nsubj|analysis subunit|dobj|2B 2B|appos|END_ENTITY	Association analysis for NMDA receptor subunit 2B -LRB- GRIN2B -RRB- genetic variants and psychopathology and clozapine response in schizophrenia .
11956967	0	NMDA	49,53	GRIN2B	75,81	NMDA	GRIN2B	D016202	2904	Chemical	Gene	subunit|compound|START_ENTITY subunit|appos|END_ENTITY	Association analysis for genetic variants of the NMDA receptor 2b subunit -LRB- GRIN2B -RRB- and Parkinson 's _ disease .
15083261	0	NMDA	28,32	GRIN2B	57,63	NMDA	GRIN2B	CHEBI:6121	2904	Chemical	Gene	glutamate|appos|START_ENTITY Association|nmod|glutamate subunit|nsubj|Association subunit|dobj|gene gene|appos|END_ENTITY	Association of a glutamate -LRB- NMDA -RRB- subunit receptor gene -LRB- GRIN2B -RRB- with obsessive-compulsive_disorder : a preliminary study .
15211626	0	NMDA	18,22	GRIN2B	49,55	NMDA	GRIN2B	CHEBI:6121	2904	Chemical	Gene	receptor|compound|START_ENTITY Variations|nmod|receptor subunit|nsubj|Variations subunit|dobj|gene gene|appos|END_ENTITY	Variations in the NMDA receptor subunit 2B gene -LRB- GRIN2B -RRB- and schizophrenia : a case-control study .
17224684	0	NMDA	30,34	GRIN2B	61,67	NMDA	GRIN2B	CHEBI:6121	2904	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association study between the NMDA receptor 2B subunit gene -LRB- GRIN2B -RRB- and schizophrenia : a HuGE review and meta-analysis .
17669510	0	NMDA	67,71	GRIN2B	94,100	NMDA	GRIN2B	CHEBI:6121	2904	Chemical	Gene	receptor|appos|START_ENTITY polymorphisms|nmod|receptor analysis|nmod|polymorphisms subunit|nsubj|analysis subunit|xcomp|gene gene|nsubj|2B 2B|appos|END_ENTITY	Association analysis of polymorphisms in the N-methyl-D-aspartate -LRB- NMDA -RRB- receptor subunit 2B -LRB- GRIN2B -RRB- gene and tardive_dyskinesia in schizophrenia .
20421849	0	NMDA	72,76	GRIN2B	103,109	NMDA	GRIN2B	CHEBI:6121	2904	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Habituation in prepulse inhibition is affected by a polymorphism on the NMDA receptor 2B subunit gene -LRB- GRIN2B -RRB- .
21827795	0	NMDA	17,21	GRIN2B	47,53	NMDA	GRIN2B	CHEBI:6121	2904	Chemical	Gene	subunit|compound|START_ENTITY Variation|nmod|subunit END_ENTITY|amod|Variation	Variation in the NMDA receptor 2B subunit gene GRIN2B is associated with differential language lateralization .
22433450	0	NMDA	24,28	GRIN2B	48,54	NMDA	GRIN2B	CHEBI:6121	2904	Chemical	Gene	receptor|compound|START_ENTITY Association|nmod|receptor END_ENTITY|nsubj|Association	Association between the NMDA glutamate receptor GRIN2B gene and obsessive-compulsive_disorder .
23408766	0	NMDA	14,18	GRIN2B	43,49	NMDA	GRIN2B	CHEBI:6121	2904	Chemical	Gene	genes|compound|START_ENTITY Assessment|nmod|genes Assessment|appos|GRIN2A GRIN2A|dep|END_ENTITY	Assessment of NMDA receptor genes -LRB- GRIN2A , GRIN2B and GRIN2C -RRB- as candidate genes in the development of degenerative_lumbar_scoliosis .
24292895	0	NMDA	45,49	GRIN2B	25,31	NMDA	GRIN2B	D016202	2904	Chemical	Gene	NR2B|compound|START_ENTITY encoding|dobj|NR2B involvement|acl|encoding involvement|nmod|END_ENTITY	Potential involvement of GRIN2B encoding the NMDA receptor subunit NR2B in the spectrum of Alzheimer 's _ disease .
9547169	0	NMDA	74,78	GRIN2B	42,48	NMDA	GRIN2B	CHEBI:6121	2904	Chemical	Gene	subunit|appos|START_ENTITY END_ENTITY|appos|subunit	mRNA distribution in adult human brain of GRIN2B , a N-methyl-D-aspartate -LRB- NMDA -RRB- receptor subunit .
25041634	0	NMDA	97,101	GRIN3A	128,134	NMDA	GRIN3A	CHEBI:6121	116443	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The assessment of the T102C polymorphism of the 5HT2a_receptor gene , 3723G/A polymorphism of the NMDA receptor 3A subunit gene -LRB- GRIN3A -RRB- and 421C/A polymorphism of the NMDA receptor 2B subunit gene -LRB- GRIN2B -RRB- among cardiac surgery patients with and without delirium .
24814139	0	NMDA	22,26	GRIN3B	42,48	NMDA	GRIN3B	CHEBI:6121	116444	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A recently-discovered NMDA receptor gene , GRIN3B , is associated with duration mismatch negativity .
23569367	0	NMDA	0,4	G_protein-coupled_receptor_kinase_6_and_b-arrestin-1	78,130	NMDA	G protein-coupled receptor kinase 6 and b-arrestin-1	CHEBI:6121	59076(Tax:10116)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	NMDA receptor regulation of levodopa-induced behavior and changes in striatal G_protein-coupled_receptor_kinase_6_and_b-arrestin-1 expression in parkinsonian rats .
20204507	0	NMDA	30,34	GluN1	44,49	NMDA	GluN1	CHEBI:6121	2902	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	Expression of the hippocampal NMDA receptor GluN1 subunit and its splicing isoforms in schizophrenia : postmortem study .
21676872	0	NMDA	86,90	GluN1	119,124	NMDA	GluN1	CHEBI:6121	2902	Chemical	Gene	receptors|appos|START_ENTITY accumulation|nmod|receptors regulate|dobj|accumulation regulate|nmod|variant variant|amod|END_ENTITY	Activity and protein_kinase_C regulate synaptic accumulation of N-methyl-D-aspartate -LRB- NMDA -RRB- receptors independently of GluN1 splice variant .
21746848	0	NMDA	70,74	GluN1	32,37	NMDA	GluN1	CHEBI:6121	2902	Chemical	Gene	opening|compound|START_ENTITY impair|dobj|opening impair|nsubj|constraints constraints|nmod|END_ENTITY	Local constraints in either the GluN1 or GluN2 subunit equally impair NMDA receptor pore opening .
22360858	0	NMDA	65,69	GluN1	23,28	NMDA	GluN1	CHEBI:6121	14810(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY expression|nmod|receptor expression|nmod|variants variants|amod|END_ENTITY	Reducing expression of GluN1 -LRB- 0XX -RRB- subunit splice variants of the NMDA receptor interferes with spatial reference memory .
22641781	0	NMDA	45,49	GluN1	0,5	NMDA	GluN1	D016202	2902	Chemical	Gene	receptors|compound|START_ENTITY control|nmod|receptors splice|dobj|control splice|nsubj|END_ENTITY	GluN1 splice variant control of GluN1/GluN2D NMDA receptors .
22937865	0	NMDA	94,98	GluN1	46,51	NMDA	GluN1	CHEBI:6121	2902	Chemical	Gene	receptors|compound|START_ENTITY delivery|nmod|receptors regulates|dobj|delivery regulates|nsubj|residue residue|nmod|domain domain|nmod|subunit subunit|amod|END_ENTITY	Single amino_acid residue in the M4 domain of GluN1 subunit regulates the surface delivery of NMDA receptors .
23454977	0	NMDA	56,60	GluN1	70,75	NMDA	GluN1	CHEBI:6121	2902	Chemical	Gene	receptor|compound|START_ENTITY signaling|nmod|receptor END_ENTITY|nsubj|signaling	Allosteric signaling and dynamics of the clamshell-like NMDA receptor GluN1 N-terminal domain .
23941530	0	NMDA	102,106	GluN1	41,46	NMDA	GluN1	CHEBI:6121	2902	Chemical	Gene	receptors|compound|START_ENTITY internalization|nmod|receptors critical|nmod|internalization END_ENTITY|acl:relcl|critical	Identification of a single amino_acid in GluN1 that is critical for glycine-primed internalization of NMDA receptors .
23972471	0	NMDA	27,31	GluN1	41,46	NMDA	GluN1	D016202	2902	Chemical	Gene	GluN2|compound|START_ENTITY GluN2|compound|END_ENTITY	Conformational analysis of NMDA receptor GluN1 , GluN2 , and GluN3 ligand-binding_domains reveals subtype-specific characteristics .
24072709	0	NMDA	88,92	GluN1	121,126	NMDA	GluN1	CHEBI:6121	24408(Tax:10116)	Chemical	Gene	receptor|appos|START_ENTITY structure|nmod|receptor antagonist|nsubj|structure antagonist|nmod|site site|amod|END_ENTITY	Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate -LRB- NMDA -RRB- receptor antagonist at the GluN1 glycine binding site .
24227730	0	NMDA	83,87	GluN1	42,47	NMDA	GluN1	CHEBI:6121	2902	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	The -1 receptor interacts directly with GluN1 but not GluN2A in the GluN1/GluN2A NMDA receptor .
25339225	0	NMDA	80,84	GluN1	33,38	NMDA	GluN1	CHEBI:6121	2902	Chemical	Gene	channel|compound|START_ENTITY contribution|nmod|channel contribution|nmod|END_ENTITY	The differential contribution of GluN1 and GluN2 to the gating operation of the NMDA receptor channel .
25896221	0	NMDA	92,96	GluN1	75,80	NMDA	GluN1	D016202	24408(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY subunit|nmod|receptor subunit|amod|END_ENTITY	Hepatic_encephalopathy induces site-specific changes in gene expression of GluN1 subunit of NMDA receptor in rat brain .
26045554	0	NMDA	75,79	GluN1	33,38	NMDA	GluN1	D016202	2902	Chemical	Gene	Receptors|compound|START_ENTITY Sites|nmod|Receptors Sites|nmod|Essential Essential|compound|END_ENTITY	Two N-glycosylation Sites in the GluN1 Subunit Are Essential for Releasing NMDA Receptors from the Endoplasmic Reticulum .
26153703	0	NMDA	54,58	GluN1	48,53	NMDA	GluN1	D016202	2902	Chemical	Gene	LBD|compound|START_ENTITY LBD|compound|END_ENTITY	Conformational Transitions in the Glycine-Bound GluN1 NMDA Receptor LBD via Single-Molecule FRET .
26306872	0	NMDA	19,23	GluN1	24,29	NMDA	GluN1	D016202	14810(Tax:10090)	Chemical	Gene	plasticity|compound|START_ENTITY plasticity|amod|END_ENTITY	Sex differences in NMDA GluN1 plasticity in rostral ventrolateral medulla neurons containing corticotropin-releasing_factor type 1 receptor following slow-pressor angiotensin_II hypertension .
21943605	0	NMDA	101,105	GluN2A	70,76	NMDA	GluN2A	CHEBI:6121	2903	Chemical	Gene	deletion|compound|START_ENTITY modes|dep|deletion modes|nmod|suppression suppression|acl|developing developing|nmod|END_ENTITY	Distinct modes of AMPA receptor suppression at developing synapses by GluN2A and GluN2B : single-cell NMDA receptor subunit deletion in vivo .
23123346	0	NMDA	45,49	GluN2A	59,65	NMDA	GluN2A	CHEBI:6121	14811(Tax:10090)	Chemical	Gene	knockout|compound|START_ENTITY knockout|compound|END_ENTITY	Increased brain monoaminergic tone after the NMDA receptor GluN2A subunit gene knockout is responsible for resistance to the hypnotic effect of nitrous_oxide .
23166606	0	NMDA	124,128	GluN2A	61,67	NMDA	GluN2A	CHEBI:6121	2903	Chemical	Gene	receptors|compound|START_ENTITY synaptic|nmod|receptors control|dobj|synaptic control|nsubj|Palmitoylation Palmitoylation|nmod|clusters clusters|nmod|C-terminus C-terminus|nmod|END_ENTITY	Palmitoylation at two cysteine clusters on the C-terminus of GluN2A and GluN2B differentially control synaptic targeting of NMDA receptors .
23320134	0	NMDA	52,56	GluN2A	22,28	NMDA	GluN2A	CHEBI:6121	2903	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Differential roles of GluN2A - and GluN2B-containing NMDA receptors in neuronal survival and death .
23352316	0	NMDA	29,33	GluN2A	103,109	NMDA	GluN2A	CHEBI:6121	24409(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY Blockade|nmod|receptors enhances|nsubj|Blockade enhances|dobj|reward reward|dep|role role|nmod|subunits subunits|amod|END_ENTITY	Blockade of ventral midbrain NMDA receptors enhances brain stimulation reward : a preferential role for GluN2A subunits .
23503100	0	NMDA	55,59	GluN2A	23,29	NMDA	GluN2A	CHEBI:6121	2903	Chemical	Gene	times|compound|START_ENTITY control|dobj|times control|nsubj|residues residues|nmod|tails tails|amod|END_ENTITY	Two serine residues on GluN2A C-terminal tails control NMDA receptor current decay times .
23557693	0	NMDA	107,111	GluN2A	89,95	NMDA	GluN2A	CHEBI:6121	14811(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY subunit|nmod|receptors subunit|amod|END_ENTITY	Dichotomy in the anxiolytic versus antidepressant effect of C-terminal truncation of the GluN2A subunit of NMDA receptors .
23611155	0	NMDA	18,22	GluN2A	0,6	NMDA	GluN2A	CHEBI:6121	24409(Tax:10116)	Chemical	Gene	subunits|compound|START_ENTITY subunits|compound|END_ENTITY	GluN2A and GluN2B NMDA receptor subunits differentially modulate striatal output pathways and contribute to levodopa-induced abnormal_involuntary_movements in dyskinetic rats .
23678131	0	NMDA	53,57	GluN2A	10,16	NMDA	GluN2A	CHEBI:6121	24409(Tax:10116)	Chemical	Gene	insertion|compound|START_ENTITY mediates|dobj|insertion mediates|nsubj|synthesis synthesis|amod|END_ENTITY	Dendritic GluN2A synthesis mediates activity-induced NMDA receptor insertion .
24298164	0	NMDA	37,41	GluN2A	0,6	NMDA	GluN2A	CHEBI:6121	2903	Chemical	Gene	receptors|compound|START_ENTITY subunit-containing|dobj|receptors subunit-containing|nsubj|END_ENTITY	GluN2A and GluN2B subunit-containing NMDA receptors in hippocampal plasticity .
24761931	0	NMDA	79,83	GluN2A	49,55	NMDA	GluN2A	CHEBI:6121	24409(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY subunits|nmod|receptors subunits|amod|END_ENTITY	Chronic_brain_inflammation causes a reduction in GluN2A and GluN2B subunits of NMDA receptors and an increase in the phosphorylation of mitogen-activated protein kinases in the hippocampus .
24871546	0	NMDA	57,61	GluN2A	12,18	NMDA	GluN2A	CHEBI:6121	2903	Chemical	Gene	effects|acl|START_ENTITY subunits|nmod|effects subunits|nsubj|role role|nmod|END_ENTITY	The role of GluN2A and GluN2B subunits on the effects of NMDA receptor antagonists in modeling schizophrenia and treating refractory_depression .
25015063	0	NMDA	22,26	GluN2A	77,83	NMDA	GluN2A	CHEBI:6121	24409(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY Clustering|nmod|receptors mediated|nsubjpass|Clustering mediated|nmod|C-terminus C-terminus|nmod|END_ENTITY	Clustering of surface NMDA receptors is mainly mediated by the C-terminus of GluN2A in cultured rat hippocampal neurons .
25083703	0	NMDA	16,20	GluN2A	30,36	NMDA	GluN2A	CHEBI:6121	14811(Tax:10090)	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	Deletion of the NMDA receptor GluN2A subunit significantly decreases dendritic growth in maturing dentate granule neurons .
25122884	0	NMDA	38,42	GluN2A	9,15	NMDA	GluN2A	CHEBI:6121	24409(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY containing|dobj|receptors END_ENTITY|acl|containing	Synaptic GluN2A and GluN2B containing NMDA receptors within the superficial dorsal horn activated following primary afferent stimulation .
25517826	0	NMDA	107,111	GluN2A	85,91	NMDA	GluN2A	CHEBI:6121	2903	Chemical	Gene	Receptor|compound|START_ENTITY Subunit|nmod|Receptor Subunit|amod|END_ENTITY	Interferon-a Induces Neurotoxicity Through Activation of the Type I Receptor and the GluN2A Subunit of the NMDA Receptor .
26679226	0	NMDA	25,29	GluN2A	18,24	NMDA	GluN2A	D016202	24409(Tax:10116)	Chemical	Gene	subunit|compound|START_ENTITY subunit|amod|END_ENTITY	The levels of the GluN2A NMDA receptor subunit are modified in both the neonatal and adult rat brain by an early experience involving denial of maternal contact .
26829109	0	NMDA	74,78	GluN2A	104,110	NMDA	GluN2A	D016202	24409(Tax:10116)	Chemical	Gene	Receptors|compound|START_ENTITY Receptors|acl|Containing Containing|dobj|Subunit Subunit|amod|END_ENTITY	MPX-004 and MPX-007 : New Pharmacological Tools to Study the Physiology of NMDA Receptors Containing the GluN2A Subunit .
26954554	0	NMDA	86,90	GluN2A	116,122	NMDA	GluN2A	D016202	2903	Chemical	Gene	Receptors|compound|START_ENTITY Receptors|acl|Containing Containing|dobj|Subunit Subunit|amod|END_ENTITY	Correction : MPX-004 and MPX-007 : New Pharmacological Tools to Study the Physiology of NMDA Receptors Containing the GluN2A Subunit .
19918059	0	NMDA	26,30	GluN2B	0,6	NMDA	GluN2B	CHEBI:6121	2904	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|nummod|END_ENTITY	GluN2B subunit-containing NMDA receptor antagonists prevent Abeta-mediated synaptic plasticity disruption in vivo .
20082612	0	NMDA	129,133	GluN2B	107,113	NMDA	GluN2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY subunit|nmod|receptor subunit|amod|END_ENTITY	Mapping the high-affinity binding domain of 5-substituted_benzimidazoles to the proximal N-terminus of the GluN2B subunit of the NMDA receptor .
20884329	0	NMDA	23,27	GluN2B	0,6	NMDA	GluN2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY subunits|nmod|receptor subunits|amod|END_ENTITY	GluN2B subunits of the NMDA receptor contribute to the AMPA receptor internalization during long-term depression in the lateral amygdala of juvenile rats .
21384103	0	NMDA	12,16	GluN2B	17,23	NMDA	GluN2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Blockade of NMDA GluN2B receptors selectively impairs behavioral flexibility but not initial discrimination learning .
21712388	0	NMDA	98,102	GluN2B	121,127	NMDA	GluN2B	CHEBI:6121	2904	Chemical	Gene	N-methyl-D-aspartic_acid|dep|START_ENTITY protein|amod|N-methyl-D-aspartic_acid protein|compound|END_ENTITY	Effect of Src kinase phosphorylation on disordered C-terminal_domain of N-methyl-D-aspartic_acid -LRB- NMDA -RRB- receptor subunit GluN2B protein .
21768120	0	NMDA	148,152	GluN2B	171,177	NMDA	GluN2B	CHEBI:6121	2904	Chemical	Gene	receptor|appos|START_ENTITY binding|nmod|receptor II|amod|binding subunit|nsubj|II subunit|dobj|END_ENTITY	Nucleotides and phosphorylation bi-directionally modulate Ca2 + / calmodulin-dependent protein kinase II -LRB- CaMKII -RRB- binding to the N-methyl-D-aspartate -LRB- NMDA -RRB- receptor subunit GluN2B .
22740692	0	NMDA	94,98	GluN2B	25,31	NMDA	GluN2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	receptors|appos|START_ENTITY trafficking|nmod|receptors controls|dobj|trafficking controls|nsubj|binding binding|nmod|subunit subunit|amod|END_ENTITY	Glutamate binding to the GluN2B subunit controls surface trafficking of N-methyl-D-aspartate -LRB- NMDA -RRB- receptors .
22960607	0	NMDA	0,4	GluN2B	5,11	NMDA	GluN2B	CHEBI:6121	14812(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	NMDA GluN2B receptors involved in the antidepressant effects of curcumin in the forced swim test .
23103326	0	NMDA	83,87	GluN2B	61,67	NMDA	GluN2B	CHEBI:6121	14812(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY subunit|nmod|receptor subunit|amod|END_ENTITY	Memory in aged mice is rescued by enhanced expression of the GluN2B subunit of the NMDA receptor .
23221411	0	NMDA	9,13	GluN2B	117,123	NMDA	GluN2B	CHEBI:6121	2904	Chemical	Gene	receptors|compound|START_ENTITY proteins|nsubj|receptors proteins|dep|role role|nmod|subunits subunits|amod|END_ENTITY	Synaptic NMDA receptors in basolateral amygdala principal neurons are triheteromeric proteins : physiological role of GluN2B subunits .
23325248	0	NMDA	73,77	GluN2B	43,49	NMDA	GluN2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Double dissociation of the requirement for GluN2B - and GluN2A-containing NMDA receptors in the destabilization and restabilization of a reconsolidating memory .
23357553	0	NMDA	120,124	GluN2B	21,27	NMDA	GluN2B	CHEBI:6121	2904	Chemical	Gene	receptors|compound|START_ENTITY inhibition|nmod|receptors contribute|nmod|inhibition contribute|nsubj|Dephosphorylation Dephosphorylation|nmod|residues residues|amod|END_ENTITY	Dephosphorylation of GluN2B C-terminal tyrosine residues does not contribute to acute ethanol inhibition of recombinant NMDA receptors .
23478024	0	NMDA	72,76	GluN2B	25,31	NMDA	GluN2B	CHEBI:6121	2904	Chemical	Gene	receptors|compound|START_ENTITY control|dobj|receptors kinase|advcl|control kinase|nsubj|END_ENTITY	Activated CaMKII couples GluN2B and casein kinase 2 to control synaptic NMDA receptors .
23585298	0	NMDA	31,35	GluN2B	83,89	NMDA	GluN2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY regulate|nsubj|receptors regulate|dobj|phosphorylation phosphorylation|nmod|site site|compound|END_ENTITY	Synaptic non-GluN2B-containing NMDA receptors regulate tyrosine phosphorylation of GluN2B 1472 tyrosine site in rat brain slices .
23884936	0	NMDA	52,56	GluN2B	34,40	NMDA	GluN2B	CHEBI:6121	14812(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY containing|dobj|receptors END_ENTITY|acl|containing	An increase in the association of GluN2B containing NMDA receptors with membrane scaffolding proteins was related to memory declines during aging .
23889203	0	NMDA	144,148	GluN2B	149,155	NMDA	GluN2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	manner|compound|START_ENTITY manner|compound|END_ENTITY	Long-term ethanol and corticosterone co-exposure sensitize the hippocampal ca1 region pyramidal cells to insult during ethanol withdrawal in an NMDA GluN2B subunit-dependent manner .
24431445	0	NMDA	68,72	GluN2B	30,36	NMDA	GluN2B	CHEBI:6121	2904	Chemical	Gene	function|compound|START_ENTITY critical|nmod|function critical|nsubj|Phosphorylation Phosphorylation|nmod|Ser1166 Ser1166|nmod|END_ENTITY	Phosphorylation of Ser1166 on GluN2B by PKA is critical to synaptic NMDA receptor function and Ca2 + signaling in spines .
24534302	0	NMDA	78,82	GluN2B	61,67	NMDA	GluN2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	In vitro and in vivo biotransformation of WMS-1410 , a potent GluN2B selective NMDA receptor antagonist .
25243192	0	NMDA	52,56	GluN2B	34,40	NMDA	GluN2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	Nociception|compound|START_ENTITY Subunit|nmod|Nociception Subunit|compound|END_ENTITY	Lentivirus Mediated siRNA against GluN2B Subunit of NMDA Receptor Reduces Nociception in a Rat Model of Neuropathic_Pain .
25459147	0	NMDA	19,23	GluN2B	94,100	NMDA	GluN2B	CHEBI:6121	2904	Chemical	Gene	excitotoxicity|compound|START_ENTITY inhibits|dobj|excitotoxicity inhibits|nmod|inhibition inhibition|nmod|subunit subunit|amod|END_ENTITY	Piroxicam inhibits NMDA receptor-mediated excitotoxicity through allosteric inhibition of the GluN2B subunit : An in silico study elucidating a novel mechanism of action of the drug .
25619731	0	NMDA	111,115	GluN2B	81,87	NMDA	GluN2B	CHEBI:6121	14812(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Dopamine depletion of the striatum causes a cell-type specific reorganization of GluN2B - and GluN2D-containing NMDA receptors .
25747876	0	NMDA	62,66	GluN2B	44,50	NMDA	GluN2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	Binding|compound|START_ENTITY END_ENTITY|dobj|Binding	Moderate Prenatal Alcohol Exposure Enhances GluN2B Containing NMDA Receptor Binding and Ifenprodil Sensitivity in Rat Agranular Insular Cortex .
25941471	0	NMDA	52,56	GluN2B	45,51	NMDA	GluN2B	D016202	2904	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Astrocytes increase the activity of synaptic GluN2B NMDA receptors .
26481044	0	NMDA	89,93	GluN2B	63,69	NMDA	GluN2B	D016202	14812(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Nampt is required for long-term depression and the function of GluN2B subunit-containing NMDA receptors .
26500840	0	NMDA	30,34	GluN2B	23,29	NMDA	GluN2B	D016202	14812(Tax:10090)	Chemical	Gene	subunits|compound|START_ENTITY subunits|amod|END_ENTITY	The role of GluN2A and GluN2B NMDA receptor subunits in AgRP and POMC neurons on body weight and glucose homeostasis .
26531150	0	NMDA	40,44	GluN2B	23,29	NMDA	GluN2B	D016202	2904	Chemical	Gene	antagonists|compound|START_ENTITY END_ENTITY|dep|antagonists	Benzo -LSB- 7 -RSB- annulene-based GluN2B selective NMDA receptor antagonists : Surprising effect of a nitro group in 2-position .
26557019	0	NMDA	41,45	GluN2B	15,21	NMDA	GluN2B	D016202	24410(Tax:10116)	Chemical	Gene	Receptor|compound|START_ENTITY Receptor|compound|END_ENTITY	Enhancement of GluN2B Subunit-Containing NMDA Receptor Underlies Serotonergic Regulation of Long-Term Potentiation after Critical Period in the Rat Visual Cortex .
26581639	0	NMDA	38,42	GluN2B	52,58	NMDA	GluN2B	D016202	24410(Tax:10116)	Chemical	Gene	subunit|compound|START_ENTITY subunit|amod|END_ENTITY	Multiple domains in the C-terminus of NMDA receptor GluN2B subunit contribute to neuronal_death following in vitro ischemia .
27016018	0	NMDA	21,25	GluN2B	76,82	NMDA	GluN2B	D016202	14812(Tax:10090)	Chemical	Gene	GluN2B|compound|START_ENTITY expression|nsubj|GluN2B expression|nmod|END_ENTITY	Simvastatin enhances NMDA receptor GluN2B expression and phosphorylation of GluN2B and GluN2A through increased histone acetylation and Src signaling in hippocampal CA1 neurons .
27040756	0	NMDA	45,49	GluN2B	21,27	NMDA	GluN2B	D016202	2904	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Fyn Kinase regulates GluN2B subunit-dominant NMDA receptors in human induced pluripotent stem cell-derived neurons .
27061977	0	NMDA	56,60	GluN2B	39,45	NMDA	GluN2B	D016202	2904	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|amod|END_ENTITY	Benzimidazolone bioisosteres of potent GluN2B selective NMDA receptor antagonists .
25426025	0	NMDA	76,80	GluN2C	28,34	NMDA	GluN2C	CHEBI:6121	2905	Chemical	Gene	receptors|compound|START_ENTITY delivery|nmod|receptors regulate|dobj|delivery regulate|nsubj|regions regions|nmod|subunit subunit|amod|END_ENTITY	Distinct regions within the GluN2C subunit regulate the surface delivery of NMDA receptors .
26229101	0	NMDA	137,141	GluN2C	96,102	NMDA	GluN2C	D016202	2905	Chemical	Gene	Receptor|appos|START_ENTITY Critical|nmod|Receptor Critical|nmod|Interaction Interaction|nmod|END_ENTITY	Identification of Novel 14-3-3 Residues that Are Critical for Isoform-Specific Interaction with GluN2C to Regulate N-methyl-D-aspartate -LRB- NMDA -RRB- Receptor Trafficking .
22564863	0	NMDA	81,85	GluN3A	55,61	NMDA	GluN3A	CHEBI:6121	191573(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Open-channel blockade is less effective on GluN3B than GluN3A subunit-containing NMDA receptors .
24386575	0	NMDA	11,15	GluN3A	0,6	NMDA	GluN3A	CHEBI:6121	116443	Chemical	Gene	subunit|compound|START_ENTITY END_ENTITY|dep|subunit	GluN3A : an NMDA receptor subunit with exquisite properties and functions .
22564863	0	NMDA	81,85	GluN3B	43,49	NMDA	GluN3B	CHEBI:6121	170796(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY END_ENTITY|nmod|receptors	Open-channel blockade is less effective on GluN3B than GluN3A subunit-containing NMDA receptors .
15519688	0	NMDA	115,119	GluR1	105,110	NMDA	GluR1	CHEBI:6121	2890	Chemical	Gene	mechanisms|compound|START_ENTITY END_ENTITY|nmod|mechanisms	Brain-derived_neurotrophic_factor acutely enhances tyrosine phosphorylation of the AMPA receptor subunit GluR1 via NMDA receptor-dependent mechanisms .
11422443	0	NMDA	0,4	GluRepsilon1	23,35	NMDA	GluRepsilon1	CHEBI:6121	14811(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY subunits|nsubj|receptor subunits|ccomp|enriched enriched|nsubjpass|END_ENTITY	NMDA receptor subunits GluRepsilon1 , GluRepsilon3 and GluRzeta1 are enriched at the mossy fibre-granule cell synapse in the adult mouse cerebellum .
12878694	0	NMDA	38,42	GluRepsilon1	25,37	NMDA	GluRepsilon1	CHEBI:6121	14811(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Locus-specific rescue of GluRepsilon1 NMDA receptors in mutant mice identifies the brain regions important for morphine tolerance and dependence .
18990258	0	NMDA	53,57	GluRepsilon1	67,79	NMDA	GluRepsilon1	CHEBI:6121	14811(Tax:10090)	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	Spontaneous hyperactivity in mutant mice lacking the NMDA receptor GluRepsilon1 subunit is aggravated during exposure to 0.1 MAC sevoflurane and is preserved after emergence from sevoflurane anaesthesia .
11711849	0	NMDA	49,53	GluRepsilon2	63,75	NMDA	GluRepsilon2	CHEBI:6121	14812(Tax:10090)	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	Regulation of acute nociceptive responses by the NMDA receptor GluRepsilon2 subunit .
15193753	0	NMDA	26,30	GluRepsilon2	56,68	NMDA	GluRepsilon2	CHEBI:6121	14812(Tax:10090)	Chemical	Gene	N-methyl-D-aspartate|appos|START_ENTITY N-methyl-D-aspartate|dep|type type|acl:relcl|important important|nsubj|END_ENTITY	The N-methyl-D-aspartate -LRB- NMDA -RRB- - type glutamate receptor GluRepsilon2 is important for delay and trace eyeblink conditioning in mice .
15064326	0	NMDA	44,48	Glycine_transporter_type_1	0,26	NMDA	Glycine transporter type 1	CHEBI:6121	116509(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|changes changes|amod|END_ENTITY	Glycine_transporter_type_1 blockade changes NMDA receptor-mediated responses and LTP in hippocampal CA1 pyramidal cells by altering extracellular glycine levels .
8955056	0	NMDA	128,132	Gp120	43,48	NMDA	Gp120	CHEBI:6121	155971(Tax:11676)	Chemical	Gene	receptors|compound|START_ENTITY involvement|nmod|receptors evidence|nmod|involvement hypothalamic-pituitary-adrenal_axis|dep|evidence activates|dobj|hypothalamic-pituitary-adrenal_axis activates|nsubj|expression expression|nmod|END_ENTITY	Central nervous system expression of HIV-1 Gp120 activates the hypothalamic-pituitary-adrenal_axis : evidence for involvement of NMDA receptors and nitric_oxide_synthase .
9335260	0	NMDA	51,55	Gp120	0,5	NMDA	Gp120	CHEBI:6121	3700	Chemical	Gene	receptors|compound|START_ENTITY site|nmod|receptors mediating|nsubj|site revert|advcl|mediating revert|nsubj|END_ENTITY	Gp120 can revert antagonism at the glycine site of NMDA receptors mediating GABA release from cultured hippocampal neurons .
8696300	0	NMDA	68,72	IFN-alpha	86,95	NMDA	IFN-alpha	CHEBI:6121	3439	Chemical	Gene	responses|compound|START_ENTITY responses|nmod|END_ENTITY	Roles of cytokines in the neural-immune interactions : modulation of NMDA responses by IFN-alpha .
14507968	0	NMDA	27,31	Interleukin-1beta	0,17	NMDA	Interleukin-1beta	CHEBI:6121	24494(Tax:10116)	Chemical	Gene	enhances|xcomp|START_ENTITY enhances|nsubj|END_ENTITY	Interleukin-1beta enhances NMDA receptor-mediated intracellular calcium increase through activation of the Src family of kinases .
15713269	0	NMDA	27,31	Interleukin-1beta	0,17	NMDA	Interleukin-1beta	CHEBI:6121	24494(Tax:10116)	Chemical	Gene	current|compound|START_ENTITY enhances|dobj|current enhances|nsubj|END_ENTITY	Interleukin-1beta enhances NMDA receptor-mediated current but inhibits excitatory synaptic transmission .
17069761	0	NMDA	23,27	Interleukin-2	0,13	NMDA	Interleukin-2	CHEBI:6121	3558	Chemical	Gene	currents|compound|START_ENTITY inhibits|dobj|currents inhibits|nsubj|END_ENTITY	Interleukin-2 inhibits NMDA receptor-mediated currents directly and may differentially affect subtypes .
7472429	0	NMDA	73,77	Interleukin-6	0,13	NMDA	Interleukin-6	CHEBI:6121	24498(Tax:10116)	Chemical	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	Interleukin-6 selectively enhances the intracellular calcium response to NMDA in developing CNS neurons .
20573904	0	NMDA	121,125	Kisspeptin	0,10	NMDA	Kisspeptin	CHEBI:6121	280287(Tax:10090)	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|signaling signaling|compound|END_ENTITY	Kisspeptin signaling is required for peripheral but not central stimulation of gonadotropin-releasing_hormone neurons by NMDA .
1874197	0	NMDA	45,49	LHRH	18,22	NMDA	LHRH	CHEBI:6121	25194(Tax:10116)	Chemical	Gene	levels|nmod|START_ENTITY levels|amod|END_ENTITY	Rapid increase in LHRH mRNA levels following NMDA .
12753088	0	NMDA	56,60	MCP-1	0,5	NMDA	MCP-1	CHEBI:6121	6347	Chemical	Gene	protects|nmod|START_ENTITY protects|nsubj|END_ENTITY	MCP-1 -LRB- CCL2 -RRB- protects human neurons and astrocytes from NMDA or HIV-tat-induced apoptosis .
12834896	0	NMDA	60,64	Microtubule-associated_protein_2	0,32	NMDA	Microtubule-associated protein 2	CHEBI:6121	25595(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	Microtubule-associated_protein_2 -LRB- MAP2 -RRB- associates with the NMDA receptor and is spatially redistributed within rat hippocampal neurons after oxygen-glucose_deprivation .
15069201	0	NMDA	43,47	NADH_dehydrogenase_subunit_2	88,116	NMDA	NADH dehydrogenase subunit 2	CHEBI:6121	4536	Chemical	Gene	receptors|compound|START_ENTITY anchoring|nmod|receptors anchoring|nmod|END_ENTITY	Unique domain anchoring of Src to synaptic NMDA receptors via the mitochondrial protein NADH_dehydrogenase_subunit_2 .
21212860	0	NMDA	62,66	NCX1	33,37	NMDA	NCX1	CHEBI:6121	29715(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Combined actions of Na/K-ATPase , NCX1 and glutamate dependent NMDA receptors in ischemic rat brain penumbra .
10619556	0	NMDA	29,33	NMDAR1	51,57	NMDA	NMDAR1	CHEBI:6121	24408(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY distribution|nmod|receptor subunit|nsubj|distribution subunit|dobj|END_ENTITY	Cellular distribution of the NMDA receptor subunit NMDAR1 in fetal ventral mesencephalon transplants in the dopamine-depleted striatum of a rat .
1356833	0	NMDA	60,64	NMDAR1	75,81	NMDA	NMDAR1	CHEBI:6121	397953(Tax:8355)	Chemical	Gene	agonist|nmod|START_ENTITY receptor|amod|agonist receptor|appos|END_ENTITY	N-acetylaspartylglutamate acts as an agonist upon homomeric NMDA receptor -LRB- NMDAR1 -RRB- expressed in Xenopus oocytes .
1409641	0	NMDA	317,321	NMDAR1	79,85	NMDA	NMDAR1	CHEBI:6121	24408(Tax:10116)	Chemical	Gene	NMDAR1|appos|START_ENTITY variants|nmod|NMDAR1 encoding|dobj|variants identified|advcl|encoding identified|csubj|Cloning Cloning|nmod|variant variant|nmod|END_ENTITY	Cloning of an apparent splice variant of the rat N-methyl-D-aspartate receptor NMDAR1 with altered sensitivity to polyamines and activators of protein kinase C. Molecular cloning identified complementary DNA species , from a rat ventral midbrain library , encoding apparent splice variants of the N-methyl-D-aspartate -LRB- NMDA -RRB- receptor NMDAR1 -LRB- which we now term NR1a -RRB- .
7979163	0	NMDA	131,135	NMDAR1	109,115	NMDA	NMDAR1	CHEBI:6121	2902	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|nmod|channel	Genomic cloning and localization by FISH and linkage analysis of the human gene encoding the primary subunit NMDAR1 -LRB- GRIN1 -RRB- of the NMDA receptor channel .
8301357	0	NMDA	50,54	NMDAR1	72,78	NMDA	NMDAR1	CHEBI:6121	24408(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY distribution|nmod|receptor subunit|nsubj|distribution subunit|dobj|END_ENTITY	Light and electron microscope distribution of the NMDA receptor subunit NMDAR1 in the rat nervous system using a selective anti-peptide antibody .
9526033	0	NMDA	62,66	NMDAR1	40,46	NMDA	NMDAR1	CHEBI:6121	2902	Chemical	Gene	receptor|compound|START_ENTITY subunit|nmod|receptor subunit|compound|END_ENTITY	-LSB- 3H -RSB- MK-801 binding and the mRNA for the NMDAR1 subunit of the NMDA receptor are differentially distributed in human and rat forebrain .
9526055	0	NMDA	46,50	NMDAR1	69,75	NMDA	NMDAR1	CHEBI:6121	24408(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY encoding|dobj|receptor mRNAs|acl|encoding studies|nmod|mRNAs subunits|nsubj|studies subunits|dobj|NMDAR2B NMDAR2B|nummod|END_ENTITY	Gene expression studies of mRNAs encoding the NMDA receptor subunits NMDAR1 , NMDAR2A , NMDAR2B , NMDAR2C , and NMDAR2D following long-term treatment with cis-and_trans-flupenthixol as a model for understanding the mode of action of schizophrenia drug treatment .
9526055	0	NMDA	46,50	NMDAR2C	95,102	NMDA	NMDAR2C	CHEBI:6121	24411(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY encoding|dobj|receptor mRNAs|acl|encoding studies|nmod|mRNAs subunits|nsubj|studies subunits|dobj|NMDAR2B NMDAR2B|nummod|END_ENTITY	Gene expression studies of mRNAs encoding the NMDA receptor subunits NMDAR1 , NMDAR2A , NMDAR2B , NMDAR2C , and NMDAR2D following long-term treatment with cis-and_trans-flupenthixol as a model for understanding the mode of action of schizophrenia drug treatment .
18554806	0	NMDA	68,72	NR-1	82,86	NMDA	NR-1	D016202	24408(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Interleukin_1beta facilitates bone_cancer_pain in rats by enhancing NMDA receptor NR-1 subunit phosphorylation .
10071784	0	NMDA	76,80	NR1	90,93	NMDA	NR1	CHEBI:6121	24408(Tax:10116)	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	Reactive affinity probes for the mapping of the glycine-binding site of the NMDA receptor NR1 subunit .
10220116	0	NMDA	32,36	NR1	46,49	NMDA	NR1	CHEBI:6121	24408(Tax:10116)	Chemical	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	Chronic phencyclidine increases NMDA receptor NR1 subunit mRNA in rat forebrain .
10327164	0	NMDA	181,185	NR1	186,189	NMDA	NR1	CHEBI:6121	24408(Tax:10116)	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	Decreased expression of N-methyl-D-aspartate -LRB- NMDA -RRB- receptors in rat dorsal root ganglion following complete Freund 's adjuvant-induced inflammation : an immunocytochemical study for NMDA NR1 subunit .
10327164	0	NMDA	46,50	NR1	186,189	NMDA	NR1	CHEBI:6121	24408(Tax:10116)	Chemical	Gene	receptors|appos|START_ENTITY expression|nmod|receptors root|nsubj|expression root|dobj|ganglion ganglion|nmod|inflammation inflammation|dep|study study|nmod|subunit subunit|compound|END_ENTITY	Decreased expression of N-methyl-D-aspartate -LRB- NMDA -RRB- receptors in rat dorsal root ganglion following complete Freund 's adjuvant-induced inflammation : an immunocytochemical study for NMDA NR1 subunit .
10340300	0	NMDA	0,4	NR1	5,8	NMDA	NR1	CHEBI:6121	2902	Chemical	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	NMDA NR1 subunit mRNA and glutamate_NMDA-sensitive binding are differentially affected in the striatum and pre-frontal cortex of Parkinson 's _ disease patients .
10479681	0	NMDA	87,91	NR1	101,104	NMDA	NR1	CHEBI:6121	14810(Tax:10090)	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	Alternative splicing of the C-terminal domain regulates cell surface expression of the NMDA receptor NR1 subunit .
10515258	0	NMDA	18,22	NR1	32,35	NMDA	NR1	CHEBI:6121	2902	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	The clustering of NMDA receptor NR1 subunit is regulated by the interaction between the C-terminal exon cassettes and the cytoskeleton .
10657028	0	NMDA	51,55	NR1	14,17	NMDA	NR1	CHEBI:6121	24408(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY subunits|nmod|receptor subunits|nsubj|Expression Expression|nmod|END_ENTITY	Expression of NR1 , NR2A-D , and NR3 subunits of the NMDA receptor in the cerebral cortex and olfactory bulb of adult rat .
10835034	0	NMDA	30,34	NR1	56,59	NMDA	NR1	CHEBI:6121	24408(Tax:10116)	Chemical	Gene	kinetics|nmod|START_ENTITY receptors|nsubj|kinetics receptors|xcomp|containing containing|dobj|subunits subunits|compound|END_ENTITY	Slow deactivation kinetics of NMDA receptors containing NR1 and NR2D subunits in rat cerebellar Purkinje cells .
10891601	0	NMDA	43,47	NR1	67,70	NMDA	NR1	CHEBI:6121	2902	Chemical	Gene	subunits|compound|START_ENTITY expression|nmod|subunits changes|nmod|expression changes|appos|END_ENTITY	Developmental changes in the expression of NMDA receptor subunits -LRB- NR1 , NR2A , NR2B -RRB- in the cat visual cortex and the effects of dark rearing .
10905617	0	NMDA	52,56	NR1	57,60	NMDA	NR1	CHEBI:6121	24408(Tax:10116)	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	Rapid and transient learning-associated increase in NMDA NR1 subunit in the rat hippocampus .
11160393	0	NMDA	84,88	NR1	18,21	NMDA	NR1	CHEBI:6121	2902	Chemical	Gene	receptors|compound|START_ENTITY expression|nmod|receptors required|nmod|expression required|nsubjpass|Assembly Assembly|nmod|subunit subunit|compound|END_ENTITY	Assembly with the NR1 subunit is required for surface expression of NR3A-containing NMDA receptors .
11163274	0	NMDA	52,56	NR1	66,69	NMDA	NR1	CHEBI:6121	2902	Chemical	Gene	variants|compound|START_ENTITY variants|compound|END_ENTITY	PDZ domain suppression of an ER retention signal in NMDA receptor NR1 splice variants .
11432984	0	NMDA	10,14	NR1	25,28	NMDA	NR1	CHEBI:6121	2902	Chemical	Gene	Glutamate|appos|START_ENTITY receptor|nsubj|Glutamate receptor|dobj|expression expression|compound|END_ENTITY	Glutamate -LRB- NMDA -RRB- receptor NR1 subunit mRNA expression in Alzheimer 's _ disease .
11553692	0	NMDA	52,56	NR1	33,36	NMDA	NR1	CHEBI:6121	24408(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY subunit|nmod|receptor subunit|compound|END_ENTITY	Increased phosphorylation of the NR1 subunit of the NMDA receptor following cerebral_ischemia .
11964556	0	NMDA	143,147	NR1	124,127	NMDA	NR1	CHEBI:6121	14810(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY subunit|nmod|receptor subunit|compound|END_ENTITY	Antagonistic effects of dopaminergic signaling and ethanol on protein kinase A-mediated phosphorylation of DARPP-32 and the NR1 subunit of the NMDA receptor .
12062468	0	NMDA	34,38	NR1	56,59	NMDA	NR1	CHEBI:6121	24408(Tax:10116)	Chemical	Gene	immunolocalization|nmod|START_ENTITY immunolocalization|dep|subunit subunit|nummod|END_ENTITY	Subcellular immunolocalization of NMDA receptor subunit NR1 , 2A , 2B in the rat vestibular periphery .
12325043	0	NMDA	55,59	NR1	78,81	NMDA	NR1	CHEBI:6121	24408(Tax:10116)	Chemical	Gene	subunit|compound|START_ENTITY subunit|appos|END_ENTITY	Repeated cocaine administration differentially affects NMDA receptor subunit -LRB- NR1 , NR2A-C -RRB- mRNAs in rat brain .
12457264	0	NMDA	110,114	NR1	106,109	NMDA	NR1	CHEBI:6121	24408(Tax:10116)	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	Cocaine treatment - and withdrawal-induced alterations in the expression and serine phosphorylation of the NR1 NMDA receptor subunit .
12676993	0	NMDA	13,17	NR1	90,93	NMDA	NR1	CHEBI:6121	14810(Tax:10090)	Chemical	Gene	NR2|compound|START_ENTITY Retention|nmod|NR2 subunits|nsubj|Retention subunits|nmod|lumen lumen|nmod|reticulum reticulum|nmod|mice mice|compound|END_ENTITY	Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice .
12697263	0	NMDA	38,42	NR1	52,55	NMDA	NR1	CHEBI:6121	2902	Chemical	Gene	transcripts|compound|START_ENTITY transcripts|compound|END_ENTITY	Quantitation of alternatively spliced NMDA receptor NR1 isoform mRNA transcripts in human brain by competitive RT-PCR .
12805203	0	NMDA	80,84	NR1	94,97	NMDA	NR1	CHEBI:6121	2902	Chemical	Gene	core|compound|START_ENTITY core|compound|END_ENTITY	Mechanisms of activation , inhibition and specificity : crystal structures of the NMDA receptor NR1 ligand-binding core .
14597226	0	NMDA	24,28	NR1	47,50	NMDA	NR1	CHEBI:6121	2902	Chemical	Gene	subunit|compound|START_ENTITY distribution|nmod|subunit distribution|appos|END_ENTITY	Laminar distribution of NMDA receptor subunit -LRB- NR1 , NR2A , NR2B -RRB- expression during the critical period in cat visual cortex .
14622087	0	NMDA	40,44	NR1	62,65	NMDA	NR1	CHEBI:6121	24408(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY populations|nmod|receptor subunit|nsubj|populations subunit|dobj|mRNA mRNA|compound|END_ENTITY	Translationally distinct populations of NMDA receptor subunit NR1 mRNA in the developing rat brain .
14712506	0	NMDA	47,51	NR1	61,64	NMDA	NR1	CHEBI:6121	24408(Tax:10116)	Chemical	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	-LSB- Correlation between basic expression level of NMDA receptor NR1 subunit protein in hippocampus and learning ability in rats -RSB- .
14712508	0	NMDA	23,27	NR1	50,53	NMDA	NR1	CHEBI:6121	2902	Chemical	Gene	receptors|compound|START_ENTITY expression|nmod|receptors composed|nsubj|expression composed|nmod|subunit subunit|compound|END_ENTITY	-LSB- Surface expression of NMDA receptors composed of NR1 subunit and NR2A subunit mutants with partially deleted C-terminus in HEK293 cells -RSB- .
15003177	0	NMDA	66,70	NR1	25,28	NMDA	NR1	CHEBI:6121	14810(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY role|nmod|receptor reveals|dobj|role reveals|nsubj|knockout knockout|compound|END_ENTITY	Inducible and reversible NR1 knockout reveals crucial role of the NMDA receptor in preserving remote memories in the brain .
15030408	0	NMDA	18,22	NR1	32,35	NMDA	NR1	CHEBI:6121	2902	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	Selective loss of NMDA receptor NR1 subunit isoforms in Alzheimer 's _ disease .
15233747	0	NMDA	62,66	NR1	76,79	NMDA	NR1	CHEBI:6121	24408(Tax:10116)	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	Peripheral noxious stimulation induces phosphorylation of the NMDA receptor NR1 subunit at the PKC-dependent site , serine-896 , in spinal cord dorsal horn neurons .
15996549	0	NMDA	58,62	NR1	43,46	NMDA	NR1	CHEBI:6121	2902	Chemical	Gene	receptors|compound|START_ENTITY Mechanism|nmod|receptors Mechanism|nmod|action action|nmod|subunit subunit|compound|END_ENTITY	Mechanism of partial agonist action at the NR1 subunit of NMDA receptors .
16046005	0	NMDA	18,22	NR1	23,26	NMDA	NR1	CHEBI:6121	14810(Tax:10090)	Chemical	Gene	mice|compound|START_ENTITY mice|compound|END_ENTITY	STOP knockout and NMDA NR1 hypomorphic mice exhibit deficits in sensorimotor gating .
16101757	0	NMDA	15,19	NR1	125,128	NMDA	NR1	CHEBI:6121	14810(Tax:10090)	Chemical	Gene	reactivation|compound|START_ENTITY Requirement|nmod|reactivation revealed|nsubj|Requirement revealed|nmod|knockout knockout|compound|END_ENTITY	Requirement of NMDA receptor reactivation for consolidation and storage of nondeclarative taste memory revealed by inducible NR1 knockout .
16150544	0	NMDA	0,4	NR1	105,108	NMDA	NR1	CHEBI:6121	2902	Chemical	Gene	treatment|compound|START_ENTITY prevents|nsubj|treatment prevents|nmod|END_ENTITY	NMDA receptor antagonist treatment at the time of nerve_injury prevents injury-induced changes in spinal NR1 and NR2B subunit expression and increases the sensitivity of residual pain behaviours to subsequently administered NMDA receptor antagonists .
16289403	0	NMDA	29,33	NR1	43,46	NMDA	NR1	CHEBI:6121	24408(Tax:10116)	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Electroacupuncture regulates NMDA receptor NR1 subunit expression via PI3-K pathway in a rat model of cerebral_ischemia-reperfusion .
16573586	0	NMDA	84,88	NR1	23,26	NMDA	NR1	CHEBI:6121	2902	Chemical	Gene	receptors|compound|START_ENTITY inhibition|nmod|receptors variants|nmod|inhibition variants|nsubj|Effects Effects|nmod|splice splice|compound|END_ENTITY	Effects of 8 different NR1 splice variants on the ethanol inhibition of recombinant NMDA receptors .
17156363	0	NMDA	69,73	NR1	65,68	NMDA	NR1	CHEBI:6121	14810(Tax:10090)	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Mouse galectin-1 inhibits the toxicity of glutamate by modifying NR1 NMDA receptor expression .
17258920	0	NMDA	70,74	NR1	84,87	NMDA	NR1	CHEBI:6121	24408(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|subunits subunits|compound|END_ENTITY	Molecular and functional studies of tilapia -LRB- Oreochromis_mossambicus -RRB- NMDA receptor NR1 subunits .
17606616	0	NMDA	100,104	NR1	45,48	NMDA	NR1	CHEBI:6121	2902	Chemical	Gene	receptor|compound|START_ENTITY assembly|nmod|receptor substrate|nmod|assembly forms|dobj|substrate forms|nsubj|receptor receptor|amod|subunit subunit|dep|END_ENTITY	N-Methyl-D-aspartate -LRB- NMDA -RRB- receptor subunit NR1 forms the substrate for oligomeric assembly of the NMDA receptor .
17606616	0	NMDA	22,26	NR1	45,48	NMDA	NR1	CHEBI:6121	2902	Chemical	Gene	receptor|appos|START_ENTITY receptor|amod|subunit subunit|dep|END_ENTITY	N-Methyl-D-aspartate -LRB- NMDA -RRB- receptor subunit NR1 forms the substrate for oligomeric assembly of the NMDA receptor .
18041094	0	NMDA	48,52	NR1	70,73	NMDA	NR1	CHEBI:6121	24408(Tax:10116)	Chemical	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	Early auditory deprivation alters expression of NMDA receptor subunit NR1 mRNA in the rat auditory cortex .
18287503	0	NMDA	49,53	NR1	82,85	NMDA	NR1	CHEBI:6121	2902	Chemical	Gene	dependent_inactivation|nmod|START_ENTITY +|dep|dependent_inactivation receptors|amod|+ controls|dobj|receptors controls|advcl|dimerizing dimerizing|dobj|termini termini|compound|END_ENTITY	Ca2 + / CaM controls Ca2 + - dependent_inactivation of NMDA receptors by dimerizing the NR1 C termini .
18309776	0	NMDA	65,69	NR1	79,82	NMDA	NR1	CHEBI:6121	2902	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	Serotonin 5-hT1A_receptor activation prevents phosphorylation of NMDA receptor NR1 subunit in cerebral_ischemia .
18644839	0	NMDA	22,26	NR1	18,21	NMDA	NR1	CHEBI:6121	14810(Tax:10090)	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	MMP-7 cleaves the NR1 NMDA receptor subunit and modifies NMDA receptor function .
18652355	0	NMDA	27,31	NR1	15,18	NMDA	NR1	CHEBI:6121	24408(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY mRNA|nmod|receptor mRNA|compound|END_ENTITY	-LSB- Expression of NR1 mRNA of NMDA receptor by gastrodine on hypoxia injury in cultured rat cerebral cortical neurons -RSB- .
18674888	0	NMDA	184,188	NR1	14,17	NMDA	NR1	CHEBI:6121	14810(Tax:10090)	Chemical	Gene	antagonist|compound|START_ENTITY MK-801|appos|antagonist sensitivity|nmod|MK-801 altered|nmod|sensitivity altered|nsubjpass|Expression Expression|nmod|subunits subunits|compound|END_ENTITY	Expression of NR1 , NR2A and NR2B NMDA receptor subunits is not altered in the genetically-inbred Balb/c mouse_strain with heightened behavioral sensitivity to MK-801 , a noncompetitive NMDA receptor antagonist .
18674888	0	NMDA	33,37	NR1	14,17	NMDA	NR1	CHEBI:6121	14810(Tax:10090)	Chemical	Gene	subunits|compound|START_ENTITY subunits|compound|END_ENTITY	Expression of NR1 , NR2A and NR2B NMDA receptor subunits is not altered in the genetically-inbred Balb/c mouse_strain with heightened behavioral sensitivity to MK-801 , a noncompetitive NMDA receptor antagonist .
19185544	0	NMDA	56,60	NR1	32,35	NMDA	NR1	CHEBI:6121	24408(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY gene|nmod|receptor gene|compound|END_ENTITY	siRNA-mediated knockdown of the NR1 subunit gene of the NMDA receptor attenuates formalin-induced pain_behaviors in adult rats .
19186032	0	NMDA	32,36	NR1	37,40	NMDA	NR1	CHEBI:6121	24408(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Interaction of dopamine D1 with NMDA NR1 receptors in rat prefrontal cortex .
19285052	0	NMDA	50,54	NR1	72,75	NMDA	NR1	D016202	14810(Tax:10090)	Chemical	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	Estradiol and lithium_chloride specifically alter NMDA receptor subunit NR1 mRNA and excitotoxicity in primary cultures .
19348736	0	NMDA	96,100	NR1	110,113	NMDA	NR1	CHEBI:6121	24408(Tax:10116)	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	Inhibitory effects of Group I metabotropic glutamate receptors antagonists on the expression of NMDA receptor NR1 subunit in morphine tolerant rats .
19394426	0	NMDA	46,50	NR1	32,35	NMDA	NR1	CHEBI:6121	24408(Tax:10116)	Chemical	Gene	function|compound|START_ENTITY modulates|dobj|function modulates|nsubj|Knockdown Knockdown|nmod|END_ENTITY	Knockdown and overexpression of NR1 modulates NMDA receptor function .
20085611	0	NMDA	19,23	NR1	4,7	NMDA	NR1	CHEBI:6121	2902	Chemical	Gene	receptor|compound|START_ENTITY subunit|nmod|receptor subunit|compound|END_ENTITY	The NR1 subunit of NMDA receptor regulates monocyte transmigration through the brain endothelial cell barrier .
20519532	0	NMDA	43,47	NR1	86,89	NMDA	NR1	CHEBI:6121	2902	Chemical	Gene	receptor|compound|START_ENTITY regulates|dobj|receptor regulates|nmod|interaction interaction|nmod|subunit subunit|compound|END_ENTITY	The DREAM protein negatively regulates the NMDA receptor through interaction with the NR1 subunit .
20599250	0	NMDA	59,63	NR1	28,31	NMDA	NR1	CHEBI:6121	2902	Chemical	Gene	receptor|compound|START_ENTITY subunits|nmod|receptor subunits|nsubj|study study|nmod|END_ENTITY	Immunocytochemical study of NR1 , NR2A and NR2B subunits of NMDA receptor in frog retina -LRB- Rana ridibunda -RRB- .
20850419	0	NMDA	15,19	NR1	38,41	NMDA	NR1	CHEBI:6121	24408(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY Alterations|nmod|receptor subunits|nsubj|Alterations subunits|dobj|END_ENTITY	Alterations of NMDA receptor subunits NR1 , NR2A and NR2B mRNA expression and their relationship to apoptosis following transient forebrain_ischemia .
21113815	0	NMDA	4,8	NR1	18,21	NMDA	NR1	CHEBI:6121	2902	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	The NMDA receptor NR1 subunit is critically involved in the regulation of NMDA receptor activity by C-terminal_Src_kinase -LRB- Csk -RRB- .
21113815	0	NMDA	74,78	NR1	18,21	NMDA	NR1	CHEBI:6121	2902	Chemical	Gene	activity|compound|START_ENTITY regulation|nmod|activity involved|nmod|regulation involved|nsubj|subunit subunit|compound|END_ENTITY	The NMDA receptor NR1 subunit is critically involved in the regulation of NMDA receptor activity by C-terminal_Src_kinase -LRB- Csk -RRB- .
21239115	0	NMDA	65,69	NR1	46,49	NMDA	NR1	CHEBI:6121	24408(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY subunit|nmod|receptor subunit|compound|END_ENTITY	RNA interference-mediated gene silence of the NR1 subunit of the NMDA receptor by subcutaneous injection of vector-encoding short hairpin RNA reduces formalin-induced nociception in the rat .
21293467	0	NMDA	9,13	NR1	23,26	NMDA	NR1	CHEBI:6121	24408(Tax:10116)	Chemical	Gene	receptor|nsubj|START_ENTITY receptor|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Enhanced NMDA receptor NR1 phosphorylation and neuronal activity in the arcuate_nucleus of hypothalamus following peripheral_inflammation .
21945132	0	NMDA	44,48	NR1	25,28	NMDA	NR1	CHEBI:6121	14810(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY subunit|nmod|receptor subunit|nummod|END_ENTITY	Heterozygous deletion of NR1 subunit of the NMDA receptor alters ethanol-related behaviors and regional expression of NR2 subunits in the brain .
22335236	0	NMDA	51,55	NR1	74,77	NMDA	NR1	CHEBI:6121	24408(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY identification|nmod|receptor subunits|nsubj|identification subunits|dobj|sites sites|compound|NR2A-D NR2A-D|compound|END_ENTITY	Mass spectrometrical identification of hippocampal NMDA receptor subunits NR1 , NR2A-D and five novel phosphorylation sites on NR2A and NR2B .
23562375	0	NMDA	25,29	NR1	30,33	NMDA	NR1	CHEBI:6121	24408(Tax:10116)	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	Immunoreactivity for the NMDA NR1 subunit in bulbospinal catecholamine and serotonin neurons of rat ventral medulla .
24231734	0	NMDA	65,69	NR1	70,73	NMDA	NR1	CHEBI:6121	14810(Tax:10090)	Chemical	Gene	subunits|compound|START_ENTITY subunits|compound|END_ENTITY	Adolescent social isolation enhances the plasmalemmal density of NMDA NR1 subunits in dendritic spines of principal neurons in the basolateral amygdala of adult mice .
25461194	0	NMDA	30,34	NR1	35,38	NMDA	NR1	CHEBI:6121	14810(Tax:10090)	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Mice with subtle reduction of NMDA NR1 receptor subunit expression have a selective decrease in mismatch negativity : Implications for schizophrenia prodromal population .
26038702	0	NMDA	65,69	NR1	79,82	NMDA	NR1	D016202	2902	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	A neuroligin-1-derived peptide stimulates phosphorylation of the NMDA receptor NR1 subunit and rescues MK-801-induced decrease in long-term potentiation and memory_impairment .
7510056	0	NMDA	57,61	NR1	38,41	NMDA	NR1	CHEBI:6121	24408(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY subunit|nmod|receptor subunit|compound|END_ENTITY	Expression of the gene coding for the NR1 subunit of the NMDA receptor during rat brain development .
7569904	0	NMDA	61,65	NR1	42,45	NMDA	NR1	CHEBI:6121	2902	Chemical	Gene	receptor|compound|START_ENTITY distribution|nmod|receptor distribution|nmod|subunit subunit|compound|END_ENTITY	Regulated subcellular distribution of the NR1 subunit of the NMDA receptor .
7841362	0	NMDA	13,17	NR1	18,21	NMDA	NR1	CHEBI:6121	2902	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Differential NMDA NR1 mRNA expression among spinal trigeminal neurons that project to different targets .
8592163	0	NMDA	12,16	NR1	91,94	NMDA	NR1	CHEBI:6121	2902	Chemical	Gene	receptors|compound|START_ENTITY display|nsubj|receptors display|dobj|characteristics characteristics|nmod|complexes complexes|nmod|subunits subunits|nummod|END_ENTITY	Presynaptic NMDA receptors display physiological characteristics of homomeric complexes of NR1 subunits that contain the exon 5 insert in the N-terminal domain .
8625412	0	NMDA	16,20	NR1	76,79	NMDA	NR1	CHEBI:6121	2902	Chemical	Gene	Inactivation|nmod|START_ENTITY receptors|nsubj|Inactivation receptors|nmod|subunit subunit|compound|END_ENTITY	Inactivation of NMDA receptors by direct interaction of calmodulin with the NR1 subunit .
9003035	0	NMDA	123,127	NR1	83,86	NMDA	NR1	CHEBI:6121	2902	Chemical	Gene	receptor|compound|START_ENTITY evidence|nmod|receptor evidence|nmod|existence existence|nmod|pool pool|nmod|subunits subunits|compound|END_ENTITY	Biochemical evidence for the existence of a pool of unassembled C2 exon-containing NR1 subunits of the mammalian forebrain NMDA receptor .
9089692	0	NMDA	60,64	NR1	148,151	NMDA	NR1	CHEBI:6121	2902	Chemical	Gene	receptor-channel|compound|START_ENTITY inactivation|nmod|receptor-channel involve|nsubj|inactivation involve|dobj|site site|nmod|subunit subunit|compound|END_ENTITY	The calcium-dependent transient inactivation of recombinant NMDA receptor-channel does not involve the high affinity calmodulin binding site of the NR1 subunit .
9100675	0	NMDA	11,15	NR1	34,37	NMDA	NR1	CHEBI:6121	2902	Chemical	Gene	subunit|compound|START_ENTITY subunit|appos|END_ENTITY	Changes of NMDA receptor subunit -LRB- NR1 , NR2B -RRB- and glutamate transporter -LRB- GLT1 -RRB- mRNA expression in Huntington 's _ disease -- an in situ hybridization study .
9153642	0	NMDA	67,71	NR1	81,84	NMDA	NR1	CHEBI:6121	24408(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY regulation|nmod|receptor an_anabolic-androgenic_steroid|nmod|regulation an_anabolic-androgenic_steroid|dep|END_ENTITY	Effects of an_anabolic-androgenic_steroid on the regulation of the NMDA receptor NR1 , NR2A and NR2B subunit mRNAs in brain regions of the male rat .
9349560	0	NMDA	118,122	NR1	144,147	NMDA	NR1	CHEBI:6121	2902	Chemical	Gene	receptors|compound|START_ENTITY receptors|acl|comprising comprising|dobj|END_ENTITY	Molecular dissection of native mammalian forebrain NMDA receptors containing the NR1_C2 exon : direct demonstration of NMDA receptors comprising NR1 , NR2A , and NR2B subunits within the same complex .
9349560	0	NMDA	51,55	NR1	144,147	NMDA	NR1	CHEBI:6121	2902	Chemical	Gene	receptors|compound|START_ENTITY dissection|nmod|receptors containing|nsubj|dissection containing|parataxis|subunits subunits|nsubj|demonstration demonstration|nmod|receptors receptors|acl|comprising comprising|dobj|END_ENTITY	Molecular dissection of native mammalian forebrain NMDA receptors containing the NR1_C2 exon : direct demonstration of NMDA receptors comprising NR1 , NR2A , and NR2B subunits within the same complex .
9425014	0	NMDA	43,47	NR1	65,68	NMDA	NR1	CHEBI:6121	2902	Chemical	Gene	receptor|compound|START_ENTITY interaction|nmod|receptor subunit|nsubj|interaction subunit|dobj|END_ENTITY	Splice variant-specific interaction of the NMDA receptor subunit NR1 with neuronal intermediate filaments .
9651202	0	NMDA	32,36	NR1	46,49	NMDA	NR1	CHEBI:6121	2902	Chemical	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	Alternative RNA splicing of the NMDA receptor NR1 mRNA in the neurons of the teleost electrosensory system .
9666074	0	NMDA	69,73	NR1	86,89	NMDA	NR1	CHEBI:6121	2902	Chemical	Gene	receptors|appos|START_ENTITY subunits|nmod|receptors Distribution|nmod|subunits Distribution|dep|END_ENTITY	Distribution and expression of the subunits of N-methyl-D-aspartate -LRB- NMDA -RRB- receptors ; NR1 , NR2A and NR2B in hypoxic_newborn_piglet_brains .
9698310	0	NMDA	50,54	NR1	72,75	NMDA	NR1	CHEBI:6121	2902	Chemical	Gene	inhibition|nmod|START_ENTITY Control|nmod|inhibition receptors|nsubj|Control receptors|nmod|subunit subunit|compound|END_ENTITY	Control of voltage-independent zinc inhibition of NMDA receptors by the NR1 subunit .
9721050	0	NMDA	101,105	NR1	81,84	NMDA	NR1	CHEBI:6121	2902	Chemical	Gene	receptor|compound|START_ENTITY subunits|nmod|receptor subunits|nummod|END_ENTITY	-LSB- 3H -RSB- MDL_105 ,519 binds with equal high affinity to both assembled and unassembled NR1 subunits of the NMDA receptor .
9751180	0	NMDA	72,76	NR1	26,29	NMDA	NR1	CHEBI:6121	2902	Chemical	Gene	receptors|compound|START_ENTITY modulation|nmod|receptors Opposing|nmod|modulation Opposing|dobj|contributions contributions|nmod|END_ENTITY	Opposing contributions of NR1 and NR2 to protein_kinase_C modulation of NMDA receptors .
9875351	0	NMDA	67,71	NR1	48,51	NMDA	NR1	CHEBI:6121	24408(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY subunit|nmod|receptor subunit|compound|END_ENTITY	Subcellular and subsynaptic distribution of the NR1 subunit of the NMDA receptor in the neostriatum and globus pallidus of the rat : co-localization at synapses with the GluR2/3 subunit of the AMPA receptor .
9932436	0	NMDA	85,89	NR1	70,73	NMDA	NR1	CHEBI:6121	2902	Chemical	Gene	receptors|compound|START_ENTITY subunit|nmod|receptors subunit|compound|END_ENTITY	The subcellular distribution of nitric_oxide synthase relative to the NR1 subunit of NMDA receptors in the cerebral cortex .
9952395	0	NMDA	106,110	NR1	54,57	NMDA	NR1	CHEBI:6121	2902	Chemical	Gene	receptors|compound|START_ENTITY inactivation|nmod|receptors +|dep|inactivation modulate|dobj|+ modulate|nsubj|Interactions Interactions|nmod|calmodulin calmodulin|nmod|subunit subunit|compound|END_ENTITY	Interactions of calmodulin and alpha-actinin with the NR1 subunit modulate Ca2 + - dependent inactivation of NMDA receptors .
9988122	0	NMDA	30,34	NR1	44,47	NMDA	NR1	CHEBI:6121	2902	Chemical	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	Region specific expression of NMDA receptor NR1 subunit mRNA in hypothalamus and pons following chronic morphine treatment .
10425109	0	NMDA	108,112	NR1/2B	101,107	NMDA	NR1/2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	antagonist|compound|START_ENTITY antagonist|compound|END_ENTITY	4-Hydroxy-1 - -LSB- 2 - -LRB- 4-hydroxyphenoxy -RRB- ethyl -RSB- -4 - -LRB- 4-methylbenzyl -RRB- piperidine : a novel , potent , and selective NR1/2B NMDA receptor antagonist .
12617901	0	NMDA	90,94	NR1/2B	65,71	NMDA	NR1/2B	CHEBI:6121	2904	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|nummod|END_ENTITY	2 - -LRB- 3,4-Dihydro-1H-isoquinolin-2yl -RRB- - pyridines as a novel class of NR1/2B subtype selective NMDA receptor antagonists .
12729659	0	NMDA	131,135	NR1/2B	106,112	NMDA	NR1/2B	CHEBI:6121	2904	Chemical	Gene	antagonists|compound|START_ENTITY subtype|dobj|antagonists subtype|nsubj|quinolines quinolines|nmod|END_ENTITY	4 - -LRB- 3,4-dihydro-1H-isoquinolin-2yl -RRB- - pyridines and 4 - -LRB- 3,4-dihydro-1H-isoquinolin-2-yl -RRB- - quinolines as potent NR1/2B subtype selective NMDA receptor antagonists .
17050728	0	NMDA	54,58	NR1/2D	47,53	NMDA	NR1/2D	CHEBI:6121	2902	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Permeant ion effects on external Mg2 + block of NR1/2D NMDA receptors .
18073110	0	NMDA	4,8	NR1_C1	18,24	NMDA	NR1 C1	CHEBI:6121	5465	Chemical	Gene	region|compound|START_ENTITY region|compound|END_ENTITY	The NMDA receptor NR1_C1 region bound to calmodulin : structural insights into functional differences between homologous domains .
18401728	0	NMDA	57,61	NR2	53,56	NMDA	NR2	CHEBI:6121	31107(Tax:7227)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Comparative analysis of the locations of the NR1 and NR2 NMDA receptor subunits in honeybee -LRB- Apis_mellifera -RRB- and fruit_fly -LRB- Drosophila_melanogaster , Canton-S wild-type -RRB- cerebral ganglia .
10070151	0	NMDA	21,25	NR2A	44,48	NMDA	NR2A	CHEBI:6121	2903	Chemical	Gene	eating|compound|START_ENTITY eating|compound|END_ENTITY	Lateral hypothalamic NMDA receptor subunits NR2A and/or NR2B mediate eating : immunochemical/behavioral evidence .
10098857	0	NMDA	69,73	NR2A	55,59	NMDA	NR2A	CHEBI:6121	24409(Tax:10116)	Chemical	Gene	subunits|compound|START_ENTITY subunits|compound|END_ENTITY	Insulin causes a transient tyrosine phosphorylation of NR2A and NR2B NMDA receptor subunits in rat hippocampus .
10336672	0	NMDA	64,68	NR2A	59,63	NMDA	NR2A	CHEBI:6121	24409(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Differential interaction of the tSXV motifs of the NR1 and NR2A NMDA receptor subunits with PSD-95 and SAP97 .
10774735	0	NMDA	111,115	NR2A	60,64	NMDA	NR2A	CHEBI:6121	2903	Chemical	Gene	receptors|compound|START_ENTITY binding|nmod|receptors +|xcomp|binding +|nsubj|residues residues|nmod|domain domain|nmod|Zn2 Zn2|compound|END_ENTITY	Four residues of the extracellular N-terminal domain of the NR2A subunit control high-affinity Zn2 + binding to NMDA receptors .
10844027	0	NMDA	94,98	NR2A	25,29	NMDA	NR2A	CHEBI:6121	14811(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY localization|nmod|receptors impairs|dobj|localization impairs|nsubj|truncation truncation|nmod|subunits subunits|nummod|END_ENTITY	C-Terminal truncation of NR2A subunits impairs synaptic but not extrasynaptic localization of NMDA receptors .
10891601	0	NMDA	43,47	NR2A	72,76	NMDA	NR2A	CHEBI:6121	2903	Chemical	Gene	subunits|compound|START_ENTITY expression|nmod|subunits changes|nmod|expression changes|appos|NR1 NR1|dep|END_ENTITY	Developmental changes in the expression of NMDA receptor subunits -LRB- NR1 , NR2A , NR2B -RRB- in the cat visual cortex and the effects of dark rearing .
11158244	0	NMDA	98,102	NR2A	68,72	NMDA	NR2A	CHEBI:6121	24409(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY phosphorylation|nmod|receptor phosphorylation|nmod|subunits subunits|compound|END_ENTITY	Protein kinase C activation induces tyrosine phosphorylation of the NR2A and NR2B subunits of the NMDA receptor .
11222640	0	NMDA	172,176	NR2A	152,156	NMDA	NR2A	CHEBI:6121	2903	Chemical	Gene	receptor|compound|START_ENTITY subunit|nmod|receptor subunit|amod|binding binding|nmod|END_ENTITY	Hippocampal synaptic plasticity involves competition between Ca2 + / calmodulin-dependent protein kinase II and postsynaptic_density_95 for binding to the NR2A subunit of the NMDA receptor .
11299320	0	NMDA	24,28	NR2A	46,50	NMDA	NR2A	CHEBI:6121	14811(Tax:10090)	Chemical	Gene	sites|compound|START_ENTITY sites|compound|END_ENTITY	Identification of mouse NMDA receptor subunit NR2A C-terminal tyrosine sites phosphorylated by coexpression with v-Src .
11478920	0	NMDA	0,4	NR2A	132,136	NMDA	NR2A	CHEBI:6121	24409(Tax:10116)	Chemical	Gene	receptor|nsubj|START_ENTITY receptor|nmod|END_ENTITY	NMDA receptor activation results in tyrosine phosphorylation of NMDA_receptor_subunit_2A -LRB- NR2A -RRB- and interaction of Pyk2 and Src with NR2A after transient cerebral_ischemia and reperfusion .
11530236	0	NMDA	105,109	NR2A	30,34	NMDA	NR2A	CHEBI:6121	14811(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY subunit|nmod|receptor expressing|dobj|subunit mice|xcomp|expressing mice|nsubj|effects effects|nmod|ethanol ethanol|nmod|END_ENTITY	Altered effects of ethanol in NR2A -LRB- DeltaC/DeltaC -RRB- mice expressing C-terminally truncated NR2A subunit of NMDA receptor .
11530236	0	NMDA	105,109	NR2A	89,93	NMDA	NR2A	CHEBI:6121	14811(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY subunit|nmod|receptor subunit|compound|END_ENTITY	Altered effects of ethanol in NR2A -LRB- DeltaC/DeltaC -RRB- mice expressing C-terminally truncated NR2A subunit of NMDA receptor .
11897845	0	NMDA	47,51	NR2A	8,12	NMDA	NR2A	CHEBI:6121	24409(Tax:10116)	Chemical	Gene	current|compound|START_ENTITY expression|nmod|current expression|compound|END_ENTITY	Reduced NR2A expression and prolonged decay of NMDA receptor-mediated synaptic current in rat vagal motoneurons following axotomy .
11955515	0	NMDA	68,72	NR2A	82,86	NMDA	NR2A	CHEBI:6121	2903	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	Identification of a new site in the S1 ligand binding region of the NMDA receptor NR2A subunit involved in receptor activation by glutamate .
11985816	0	NMDA	75,79	NR2A	39,43	NMDA	NR2A	CHEBI:6121	2903	Chemical	Gene	receptors|compound|START_ENTITY desensitization|nmod|receptors acts|nmod|desensitization acts|nmod|C-terminus C-terminus|nmod|END_ENTITY	Calcineurin acts via the C-terminus of NR2A to modulate desensitization of NMDA receptors .
12103442	0	NMDA	15,19	NR2A	45,49	NMDA	NR2A	CHEBI:6121	14811(Tax:10090)	Chemical	Gene	onset|nmod|START_ENTITY receptor|nsubj|onset receptor|dobj|expression expression|appos|END_ENTITY	Early onset of NMDA receptor GluR_epsilon_1 -LRB- NR2A -RRB- expression and its abundant postsynaptic localization in developing motoneurons of the mouse hypoglossal nucleus .
12147342	0	NMDA	55,59	NR2A	29,33	NMDA	NR2A	CHEBI:6121	2903	Chemical	Gene	subunits|nmod|START_ENTITY subunits|compound|END_ENTITY	Sequence determinants on the NR2A and NR2B subunits of NMDA receptor responsible for specificity of phosphorylation by CaMKII .
12560119	0	NMDA	0,4	NR2A	71,75	NMDA	NR2A	CHEBI:6121	24409(Tax:10116)	Chemical	Gene	blockade|compound|START_ENTITY increases|nsubj|blockade increases|dobj|trafficking trafficking|nmod|subunits subunits|nummod|END_ENTITY	NMDA receptor blockade in intact adult cortex increases trafficking of NR2A subunits into spines , postsynaptic densities , and axon terminals .
14597226	0	NMDA	24,28	NR2A	52,56	NMDA	NR2A	CHEBI:6121	2903	Chemical	Gene	subunit|compound|START_ENTITY distribution|nmod|subunit distribution|appos|NR1 NR1|dep|END_ENTITY	Laminar distribution of NMDA receptor subunit -LRB- NR1 , NR2A , NR2B -RRB- expression during the critical period in cat visual cortex .
14985927	0	NMDA	108,112	NR2A	75,79	NMDA	NR2A	CHEBI:6121	14811(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY required|nsubjpass|receptors containing|ccomp|required subunit|xcomp|containing subunit|nsubj|inhibition inhibition|nmod|END_ENTITY	Pharmacological and genetic evidence indicates that combined inhibition of NR2A and NR2B subunit containing NMDA receptors is required to disrupt prepulse inhibition .
15356193	0	NMDA	47,51	NR2A	22,26	NMDA	NR2A	CHEBI:6121	2903	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression .
15748161	0	NMDA	64,68	NR2A	90,94	NMDA	NR2A	CHEBI:6121	100126660(Tax:8355)	Chemical	Gene	receptors|compound|START_ENTITY insulin|nmod|receptors containing|nsubj|insulin containing|dobj|subunits subunits|compound|END_ENTITY	PKC site mutations reveal differential modulation by insulin of NMDA receptors containing NR2A or NR2B subunits .
15924861	0	NMDA	48,52	NR2A	22,26	NMDA	NR2A	CHEBI:6121	2903	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Differential roles of NR2A - and NR2B-containing NMDA receptors in Ras-ERK signaling and AMPA receptor trafficking .
15928921	0	NMDA	123,127	NR2A	75,79	NMDA	NR2A	CHEBI:6121	2903	Chemical	Gene	receptor|appos|START_ENTITY subunits|nmod|receptor subunits|compound|END_ENTITY	Comparative analysis of different competitive antagonists interaction with NR2A and NR2B subunits of N-methyl-D-aspartate -LRB- NMDA -RRB- ionotropic glutamate receptor .
16166158	0	NMDA	100,104	NR2A	69,73	NMDA	NR2A	CHEBI:6121	2903	Chemical	Gene	receptors|compound|START_ENTITY desensitization|nmod|receptors causes|dobj|desensitization causes|nsubj|interaction interaction|nmod|domains domains|nmod|END_ENTITY	Allosteric interaction between zinc and glutamate binding domains on NR2A causes desensitization of NMDA receptors .
16221859	0	NMDA	64,68	NR2A	78,82	NMDA	NR2A	CHEBI:6121	2903	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	The nonkinase phorbol_ester receptor alpha 1-chimerin binds the NMDA receptor NR2A subunit and regulates dendritic spine density .
16386794	0	NMDA	77,81	NR2A	56,60	NMDA	NR2A	CHEBI:6121	24409(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY subunits|nmod|receptor subunits|nummod|END_ENTITY	Perinatal exposure to PTU delays switching from NR2B to NR2A subunits of the NMDA receptor in the rat cerebellum .
16482087	0	NMDA	28,32	NR2A	42,46	NMDA	NR2A	CHEBI:6121	14811(Tax:10090)	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	Genetic inactivation of the NMDA receptor NR2A subunit has anxiolytic - and antidepressant-like effects in mice .
16709630	0	NMDA	118,122	NR2A	113,117	NMDA	NR2A	CHEBI:6121	100126660(Tax:8355)	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	Single-channel analysis of a point mutation of a conserved serine residue in the S2 ligand-binding domain of the NR2A NMDA receptor subunit .
16835771	0	NMDA	46,50	NR2A	60,64	NMDA	NR2A	CHEBI:6121	14811(Tax:10090)	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	Ethanol-related behaviors in mice lacking the NMDA receptor NR2A subunit .
16904707	0	NMDA	47,51	NR2A	22,26	NMDA	NR2A	CHEBI:6121	24409(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Differential roles of NR2A and NR2B-containing NMDA receptors in LTP and LTD in the CA1 region of two-week old rat hippocampus .
17156360	0	NMDA	23,27	NR2A	59,63	NMDA	NR2A	CHEBI:6121	24409(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY switching|nmod|receptor subunits|nsubj|switching subunits|nmod|END_ENTITY	Postnatal switching of NMDA receptor subunits from NR2B to NR2A in rat facial motor neurons .
17234586	0	NMDA	48,52	NR2A	22,26	NMDA	NR2A	CHEBI:6121	2903	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Differential roles of NR2A - and NR2B-containing NMDA receptors in activity-dependent brain-derived_neurotrophic_factor gene regulation and limbic epileptogenesis .
17470281	0	NMDA	89,93	NR2A	63,67	NMDA	NR2A	CHEBI:6121	2903	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Pharmacological isolation of postsynaptic currents mediated by NR2A - and NR2B-containing NMDA receptors in the anterior cingulate cortex .
17486105	0	NMDA	98,102	NR2A	68,72	NMDA	NR2A	CHEBI:6121	2903	Chemical	Gene	receptor|compound|START_ENTITY truncation|nmod|receptor truncation|nmod|subunits subunits|compound|END_ENTITY	Excitotoxicity and focal cerebral_ischemia induce truncation of the NR2A and NR2B subunits of the NMDA receptor and cleavage of the scaffolding protein PSD-95 .
17519952	0	NMDA	25,29	NR2A	39,43	NMDA	NR2A	CHEBI:6121	2903	Chemical	Gene	influence|compound|START_ENTITY influence|compound|END_ENTITY	Mutations at F637 in the NMDA receptor NR2A subunit M3 domain influence agonist potency , ion channel gating and alcohol action .
17570444	0	NMDA	53,57	NR2A	27,31	NMDA	NR2A	CHEBI:6121	2903	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|vitro vitro|nmod|END_ENTITY	Excitotoxicity in vitro by NR2A - and NR2B-containing NMDA receptors .
17585958	0	NMDA	48,52	NR2A	22,26	NMDA	NR2A	CHEBI:6121	2903	Chemical	Gene	synthesis|compound|START_ENTITY subtypes|nmod|synthesis subtypes|nsubj|roles roles|nmod|END_ENTITY	Differential roles of NR2A and NR2B subtypes in NMDA receptor-dependent protein synthesis in dendrites .
17986236	0	NMDA	33,37	NR2A	0,4	NMDA	NR2A	CHEBI:6121	2903	Chemical	Gene	receptors|compound|START_ENTITY regulate|nsubj|receptors containing|ccomp|regulate subunit|xcomp|containing subunit|nsubj|END_ENTITY	NR2A and NR2B subunit containing NMDA receptors differentially regulate striatal output pathways .
18048007	0	NMDA	53,57	NR2A	27,31	NMDA	NR2A	CHEBI:6121	24409(Tax:10116)	Chemical	Gene	responses|compound|START_ENTITY responses|amod|END_ENTITY	Glycine modulates synaptic NR2A - and NR2B-containing NMDA receptor-mediated responses in the rat visual cortex .
18178157	0	NMDA	4,8	NR2A	18,22	NMDA	NR2A	CHEBI:6121	2903	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	The NMDA receptor NR2A subunit regulates proliferation of MKN45 human gastric_cancer cells .
18230672	0	NMDA	53,57	NR2A	67,71	NMDA	NR2A	CHEBI:6121	14811(Tax:10090)	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	Impaired discrimination learning in mice lacking the NMDA receptor NR2A subunit .
18435828	0	NMDA	55,59	NR2A	23,27	NMDA	NR2A	CHEBI:6121	24409(Tax:10116)	Chemical	Gene	antagonists|compound|START_ENTITY subunit|dobj|antagonists subunit|nsubj|effect effect|nmod|END_ENTITY	Differential effect of NR2A and NR2B subunit selective NMDA receptor antagonists on striato-pallidal neurons : relationship to motor response in the 6-hydroxydopamine model of parkinsonism .
18765272	0	NMDA	190,194	NR2A	164,168	NMDA	NR2A	CHEBI:6121	24409(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	The protective effects of Achyranthes bidentata polypeptides against NMDA-induced cell apoptosis in cultured hippocampal neurons through differential modulation of NR2A - and NR2B-containing NMDA receptors .
18992785	0	NMDA	44,48	NR2A	18,22	NMDA	NR2A	CHEBI:6121	2903	Chemical	Gene	receptor|compound|START_ENTITY subunits|nmod|receptor subunits|nsubj|levels levels|nmod|END_ENTITY	Reduced levels of NR2A and NR2B subunits of NMDA receptor and PSD-95 in the prefrontal cortex in major_depression .
19474217	0	NMDA	35,39	NR2A	5,9	NMDA	NR2A	CHEBI:6121	14811(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY subunits|nmod|receptor subunits|compound|END_ENTITY	Both NR2A and NR2B subunits of the NMDA receptor are critical for long-term potentiation and long-term depression in the lateral amygdala of horizontal slices of adult mice .
19533626	0	NMDA	33,37	NR2A	28,32	NMDA	NR2A	CHEBI:6121	24409(Tax:10116)	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	Increased expression of the NR2A NMDA receptor subunit in the prefrontal cortex of rats reared in isolation .
19686722	0	NMDA	42,46	NR2A	105,109	NMDA	NR2A	CHEBI:6121	14811(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY antagonism|nmod|receptor non-selective|nsubj|antagonism non-selective|xcomp|containing containing|dobj|subunits subunits|compound|END_ENTITY	The xenon-mediated antagonism against the NMDA receptor is non-selective for receptors containing either NR2A or NR2B subunits in the mouse amygdala .
19795494	0	NMDA	20,24	NR2A	34,38	NMDA	NR2A	CHEBI:6121	14811(Tax:10090)	Chemical	Gene	subunits|compound|START_ENTITY subunits|compound|END_ENTITY	Increased levels of NMDA receptor NR2A subunits at pre - and postsynaptic sites of the hippocampal CA1 : an early response to conditional double knockout of presenilin_1_and_2 .
19811606	0	NMDA	82,86	NR2A	56,60	NMDA	NR2A	CHEBI:6121	2903	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Amyloid precursor protein 695 associates with assembled NR2A - and NR2B-containing NMDA receptors to result in the enhancement of their cell surface delivery .
19893758	0	NMDA	39,43	NR2A	9,13	NMDA	NR2A	CHEBI:6121	2903	Chemical	Gene	Receptors|compound|START_ENTITY Increase|nsubj|Receptors END_ENTITY|parataxis|Increase	Synaptic NR2A - but not NR2B-Containing NMDA Receptors Increase with Blockade of Ionotropic Glutamate Receptors .
20810618	0	NMDA	45,49	NR2A	85,89	NMDA	NR2A	CHEBI:6121	2903	Chemical	Gene	START_ENTITY|xcomp|selective selective|nmod|END_ENTITY	Identification and characterization of novel NMDA receptor antagonists selective for NR2A - over NR2B-containing receptors .
21521618	0	NMDA	71,75	NR2A	93,97	NMDA	NR2A	CHEBI:6121	14811(Tax:10090)	Chemical	Gene	NR2B|compound|START_ENTITY NR2B|nmod|switch switch|compound|END_ENTITY	mGluR5 and NMDA receptors drive the experience - and activity-dependent NMDA receptor NR2B to NR2A subunit switch .
21604481	0	NMDA	30,34	NR2A	54,58	NMDA	NR2A	CHEBI:6121	2903	Chemical	Gene	subunits|compound|START_ENTITY Roles|nmod|subunits Roles|appos|END_ENTITY	-LSB- Roles and expressions of the NMDA receptor subunits -LRB- NR2A and NR2B -RRB- in visual cortex area of kittens with the normal visual development and anisometropic_amblyopia -RSB- .
21725314	0	NMDA	58,62	NR2A	72,76	NMDA	NR2A	CHEBI:6121	14811(Tax:10090)	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	Zinc alleviates pain through high-affinity binding to the NMDA receptor NR2A subunit .
22335236	0	NMDA	51,55	NR2A	126,130	NMDA	NR2A	CHEBI:6121	24409(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY identification|nmod|receptor subunits|nsubj|identification subunits|nmod|END_ENTITY	Mass spectrometrical identification of hippocampal NMDA receptor subunits NR1 , NR2A-D and five novel phosphorylation sites on NR2A and NR2B .
23676200	0	NMDA	26,30	NR2A	0,4	NMDA	NR2A	CHEBI:6121	2903	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	NR2A - and NR2B-containing NMDA receptors in the prelimbic medial prefrontal cortex differentially mediate trace , delay , and contextual fear conditioning .
24349798	0	NMDA	0,4	NR2A	72,76	NMDA	NR2A	CHEBI:6121	24409(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|advcl|targeting targeting|dobj|receptors receptors|nummod|END_ENTITY	NMDA reduces Tau phosphorylation in rat hippocampal slices by targeting NR2A receptors , GSK3b , and PKC activities .
25042179	0	NMDA	33,37	NR2A	95,99	NMDA	NR2A	CHEBI:6121	24409(Tax:10116)	Chemical	Gene	Receptors|compound|START_ENTITY Receptors|nmod|Subunits Subunits|compound|END_ENTITY	D-Serine-induced Inactivation of NMDA Receptors in Cultured Rat Hippocampal Neurons Expressing NR2A Subunits is Ca -LRB- 2 + -RRB- - Dependent .
25521238	0	NMDA	53,57	NR2A	76,80	NMDA	NR2A	D016202	24409(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY supplementation|nmod|receptor effects|nmod|supplementation subunits|nsubj|effects subunits|dobj|END_ENTITY	The effects of walnut supplementation on hippocampal NMDA receptor subunits NR2A and NR2B of rats .
26184010	0	NMDA	37,41	NR2A	23,27	NMDA	NR2A	D016202	24409(Tax:10116)	Chemical	Gene	antagonism|compound|START_ENTITY antagonism|compound|END_ENTITY	Dissociable effects of NR2A and NR2B NMDA receptor antagonism on cognitive_flexibility but not pattern separation .
7488151	0	NMDA	0,4	NR2A	34,38	NMDA	NR2A	CHEBI:6121	24409(Tax:10116)	Chemical	Gene	subunits|compound|START_ENTITY epsilon|nsubj|subunits epsilon|ccomp|substrates substrates|nsubj|1 1|appos|END_ENTITY	NMDA receptor subunits epsilon 1 -LRB- NR2A -RRB- and epsilon 2 -LRB- NR2B -RRB- are substrates for Fyn in the postsynaptic density fraction isolated from the rat brain .
7790859	0	NMDA	20,24	NR2A	79,83	NMDA	NR2A	CHEBI:6121	24409(Tax:10116)	Chemical	Gene	antibodies|compound|START_ENTITY Characterization|nmod|antibodies Characterization|dep|distribution distribution|nmod|subunits subunits|compound|END_ENTITY	Characterization of NMDA receptor subunit-specific antibodies : distribution of NR2A and NR2B receptor subunits in rat brain and ontogenic profile in the cerebellum .
7836563	0	NMDA	49,53	NR2A	71,75	NMDA	NR2A	CHEBI:6121	2903	Chemical	Gene	receptor|compound|START_ENTITY expression|nmod|receptor subunit|nsubj|expression subunit|dobj|END_ENTITY	Localization and developmental expression of the NMDA receptor subunit NR2A in the mammalian retina .
7931566	0	NMDA	4,8	NR2A	27,31	NMDA	NR2A	CHEBI:6121	24409(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY subunits|nsubj|receptor subunits|ccomp|show show|nsubj|END_ENTITY	The NMDA receptor subunits NR2A and NR2B show histological and ultrastructural localization patterns similar to those of NR1 .
8742413	0	NMDA	16,20	NR2A	47,51	NMDA	NR2A	CHEBI:6121	24409(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY Distribution|nmod|receptor subunit|nsubj|Distribution subunit|dobj|proteins proteins|nummod|END_ENTITY	Distribution of NMDA receptor subunit proteins NR2A , 2B , 2C and 2D in rat brain .
9003031	0	NMDA	0,4	NR2A	106,110	NMDA	NR2A	CHEBI:6121	24409(Tax:10116)	Chemical	Gene	heterogeneity|compound|START_ENTITY heterogeneity|dep|expression expression|nmod|END_ENTITY	NMDA receptor heterogeneity during postnatal development of the rat brain : differential expression of the NR2A , NR2B , and NR2C subunit proteins .
9065507	0	NMDA	33,37	NR2A	0,4	NMDA	NR2A	CHEBI:6121	2903	Chemical	Gene	currents|compound|START_ENTITY shortens|dobj|currents shortens|nsubj|expression expression|nummod|END_ENTITY	NR2A subunit expression shortens NMDA receptor synaptic currents in developing neocortex .
9153642	0	NMDA	67,71	NR2A	86,90	NMDA	NR2A	CHEBI:6121	24409(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY regulation|nmod|receptor an_anabolic-androgenic_steroid|nmod|regulation an_anabolic-androgenic_steroid|dep|NR1 NR1|nummod|END_ENTITY	Effects of an_anabolic-androgenic_steroid on the regulation of the NMDA receptor NR1 , NR2A and NR2B subunit mRNAs in brain regions of the male rat .
9425000	0	NMDA	113,117	NR2A	45,49	NMDA	NR2A	CHEBI:6121	2903	Chemical	Gene	receptors|compound|START_ENTITY glutamate|nmod|receptors subunit|ccomp|glutamate subunit|nsubj|Identification Identification|nmod|residues residues|nmod|END_ENTITY	Identification of amino_acid residues of the NR2A subunit that control glutamate potency in recombinant NR1/NR2A NMDA receptors .
9490809	0	NMDA	51,55	NR2A	26,30	NMDA	NR2A	CHEBI:6121	24409(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY subunit|nmod|receptors subunit|nsubj|contribution contribution|nmod|END_ENTITY	Increased contribution of NR2A subunit to synaptic NMDA receptors in developing rat cortical neurons .
12325043	0	NMDA	55,59	NR2A-C	83,89	NMDA	NR2A-C	CHEBI:6121	24408(Tax:10116)	Chemical	Gene	subunit|compound|START_ENTITY subunit|appos|NR1 NR1|dep|END_ENTITY	Repeated cocaine administration differentially affects NMDA receptor subunit -LRB- NR1 , NR2A-C -RRB- mRNAs in rat brain .
10064891	0	NMDA	95,99	NR2B	109,113	NMDA	NR2B	CHEBI:6121	2904	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	Potential involvement of tyrosine kinase pathway in the antagonist induced upregulation of the NMDA receptor NR2B subunit in cortical neurons .
10070151	0	NMDA	21,25	NR2B	56,60	NMDA	NR2B	CHEBI:6121	2904	Chemical	Gene	eating|compound|START_ENTITY eating|compound|END_ENTITY	Lateral hypothalamic NMDA receptor subunits NR2A and/or NR2B mediate eating : immunochemical/behavioral evidence .
10213801	0	NMDA	26,30	NR2B	56,60	NMDA	NR2B	CHEBI:6121	2904	Chemical	Gene	receptors|compound|START_ENTITY receptors|acl|containing containing|dobj|subunit subunit|compound|END_ENTITY	Antagonists selective for NMDA receptors containing the NR2B subunit .
10340299	0	NMDA	10,14	NR2B	126,130	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	antagonists|compound|START_ENTITY induce|nsubj|antagonists induce|dobj|correlation correlation|nmod|localisation localisation|nmod|subunit subunit|nummod|END_ENTITY	Selective NMDA NR2B antagonists induce antinociception without motor_dysfunction : correlation with restricted localisation of NR2B subunit in dorsal horn .
10340299	0	NMDA	10,14	NR2B	15,19	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|compound|END_ENTITY	Selective NMDA NR2B antagonists induce antinociception without motor_dysfunction : correlation with restricted localisation of NR2B subunit in dorsal horn .
10407167	0	NMDA	91,95	NR2B	114,118	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	subunit|compound|START_ENTITY subunit|appos|END_ENTITY	Osmotic activation of the hypothalamo-neurohypophysial system reversibly downregulates the NMDA receptor subunit , NR2B , in the supraoptic nucleus of the hypothalamus .
10464027	0	NMDA	93,97	NR2B	70,74	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|compound|END_ENTITY	Structure-activity relationship of N - -LRB- phenylalkyl -RRB- cinnamides as novel NR2B subtype-selective NMDA receptor antagonists .
10634899	0	NMDA	5,9	NR2B	89,93	NMDA	NR2B	CHEBI:6121	14812(Tax:10090)	Chemical	Gene	receptor-mediated|nsubj|START_ENTITY receptor-mediated|nmod|mice mice|acl|lacking lacking|dobj|subunit subunit|appos|END_ENTITY	Fast NMDA receptor-mediated synaptic currents in neurons from mice lacking the epsilon2 -LRB- NR2B -RRB- subunit .
10760358	0	NMDA	38,42	NR2B	15,19	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	antagonist|compound|START_ENTITY antagonist|compound|END_ENTITY	CP-101 ,606 , an NR2B subunit selective NMDA receptor antagonist , inhibits NMDA and injury induced c-fos expression and cortical spreading depression in rodents .
10760358	0	NMDA	73,77	NR2B	15,19	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|CP-101 CP-101|appos|antagonist antagonist|compound|END_ENTITY	CP-101 ,606 , an NR2B subunit selective NMDA receptor antagonist , inhibits NMDA and injury induced c-fos expression and cortical spreading depression in rodents .
10891601	0	NMDA	43,47	NR2B	78,82	NMDA	NR2B	CHEBI:6121	2904	Chemical	Gene	subunits|compound|START_ENTITY expression|nmod|subunits changes|nmod|expression changes|appos|NR1 NR1|dep|END_ENTITY	Developmental changes in the expression of NMDA receptor subunits -LRB- NR1 , NR2A , NR2B -RRB- in the cat visual cortex and the effects of dark rearing .
10924926	0	NMDA	44,48	NR2B	20,24	NMDA	NR2B	CHEBI:6121	14812(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Implications of the NR2B subunit-containing NMDA receptor localized in mouse limbic forebrain in ethanol dependence .
11080199	0	NMDA	24,28	NR2B	46,50	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY expression|nmod|receptor subunit|nsubj|expression subunit|dobj|END_ENTITY	Transient expression of NMDA receptor subunit NR2B in the developing rat heart .
11517276	0	NMDA	51,55	NR2B	31,35	NMDA	NR2B	CHEBI:6121	2904	Chemical	Gene	receptor|compound|START_ENTITY subunit|nmod|receptor subunit|compound|END_ENTITY	Intra-amygdala blockade of the NR2B subunit of the NMDA receptor disrupts the acquisition but not the expression of fear conditioning .
11730974	0	NMDA	0,4	NR2B	54,58	NMDA	NR2B	CHEBI:6121	2904	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|dep|focus focus|nmod|subtype subtype|compound|END_ENTITY	NMDA receptor antagonists as analgesics : focus on the NR2B subtype .
11841566	0	NMDA	101,105	NR2B	149,153	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY involvement|nmod|receptor involvement|acl|inhibition inhibition|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Lithium protection against glutamate excitotoxicity in rat cerebral cortical neurons : involvement of NMDA receptor inhibition possibly by decreasing NR2B tyrosine phosphorylation .
11945135	0	NMDA	15,19	NR2B	0,4	NMDA	NR2B	CHEBI:6121	2904	Chemical	Gene	antagonists|compound|START_ENTITY END_ENTITY|dep|antagonists	NR2B selective NMDA receptor antagonists .
12088721	0	NMDA	221,225	NR2B	197,201	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|nummod|END_ENTITY	Synthesis , in vitro and in vivo pharmacology of a C-11 labeled analog of CP-101 ,606 , -LRB- + / - -RRB- threo-1 - -LRB- 4-hydroxyphenyl -RRB- -2 - -LSB- 4-hydroxy-4 - -LRB- p - -LSB- 11C -RSB- methoxyphenyl -RRB- piperidino -RSB- -1 - propanol , as a PET tracer for NR2B subunit-containing NMDA receptors .
12122079	0	NMDA	52,56	NR2B	32,36	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY phosphorylation|nmod|receptor phosphorylation|nmod|subunit subunit|compound|END_ENTITY	Tyrosine phosphorylation of the NR2B subunit of the NMDA receptor in the spinal cord during the development and maintenance of inflammatory hyperalgesia .
12323394	0	NMDA	15,19	NR2B	10,14	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|compound|END_ENTITY	Selective NR2B NMDA receptor antagonists are protective against staurosporine-induced apoptosis .
12429230	0	NMDA	92,96	NR2B	72,76	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY subunit|nmod|receptor subunit|compound|END_ENTITY	Okadaic_acid induces epileptic_seizures and hyperphosphorylation of the NR2B subunit of the NMDA receptor in rat hippocampus in vivo .
12555271	0	NMDA	23,27	NR2B	37,41	NMDA	NR2B	CHEBI:6121	2904	Chemical	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	Seasonal regulation of NMDA receptor NR2B mRNA in the adult canary song system .
12593629	0	NMDA	100,104	NR2B	84,88	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY subunit|nmod|receptors subunit|compound|END_ENTITY	Reduced brain infarct volume and improved neurological outcome by inhibition of the NR2B subunit of NMDA receptors by using CP101,606-27 alone and in combination with rt-PA in a thromboembolic_stroke model in rats .
12604092	0	NMDA	126,130	NR2B	121,125	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Evaluation of the NR2B-selective NMDA receptor antagonist Ro_63-1908 on rodent behaviour : evidence for an involvement of NR2B NMDA receptors in response inhibition .
12604092	0	NMDA	33,37	NR2B	121,125	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	Ro_63-1908|compound|START_ENTITY Evaluation|nmod|Ro_63-1908 Evaluation|dep|evidence evidence|nmod|involvement involvement|nmod|receptors receptors|compound|END_ENTITY	Evaluation of the NR2B-selective NMDA receptor antagonist Ro_63-1908 on rodent behaviour : evidence for an involvement of NR2B NMDA receptors in response inhibition .
12639560	0	NMDA	62,66	NR2B	39,43	NMDA	NR2B	CHEBI:6121	2904	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|nummod|END_ENTITY	Novel N1 - -LRB- benzyl -RRB- cinnamamidine derived NR2B subtype-selective NMDA receptor antagonists .
12676529	0	NMDA	81,85	NR2B	112,116	NMDA	NR2B	CHEBI:6121	2904	Chemical	Gene	proteins|compound|START_ENTITY proteins|dep|END_ENTITY	Coincidence in dendritic clustering and synaptic targeting of homer proteins and NMDA receptor complex proteins NR2B and PSD95 during development of cultured hippocampal neurons .
12832518	0	NMDA	79,83	NR2B	0,4	NMDA	NR2B	CHEBI:6121	14812(Tax:10090)	Chemical	Gene	subtype|compound|START_ENTITY form|dobj|subtype subunits|xcomp|form subunits|nsubj|END_ENTITY	NR2B and NR2D subunits coassemble in cerebellar Golgi cells to form a distinct NMDA receptor subtype restricted to extrasynaptic sites .
12832545	0	NMDA	117,121	NR2B	88,92	NMDA	NR2B	CHEBI:6121	2904	Chemical	Gene	receptor|compound|START_ENTITY subunit|nmod|receptor subunit|nummod|END_ENTITY	Decline of the critical period of visual plasticity is concurrent with the reduction of NR2B subunit of the synaptic NMDA receptor in layer 4 .
12835117	0	NMDA	107,111	NR2B	102,106	NMDA	NR2B	CHEBI:6121	2904	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|compound|END_ENTITY	Studies on neuronal apoptosis in primary forebrain cultures : neuroprotective/anti-apoptotic action of NR2B NMDA antagonists .
12963084	0	NMDA	23,27	NR2B	0,4	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|nummod|END_ENTITY	NR2B subunit selective NMDA antagonists inhibit neurotoxic effect of alcohol-withdrawal in primary cultures of rat cortical neurones .
12969766	0	NMDA	35,39	NR2B	49,53	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	The effect of -LRB- + / - -RRB- - CP-101 ,606 , an NMDA receptor NR2B subunit selective antagonist , in the Morris watermaze .
14552795	0	NMDA	46,50	NR2B	31,35	NMDA	NR2B	CHEBI:6121	2904	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|nummod|END_ENTITY	Indole-2-carboxamides as novel NR2B selective NMDA receptor antagonists .
14597226	0	NMDA	24,28	NR2B	58,62	NMDA	NR2B	CHEBI:6121	2904	Chemical	Gene	subunit|compound|START_ENTITY distribution|nmod|subunit distribution|appos|NR1 NR1|dep|END_ENTITY	Laminar distribution of NMDA receptor subunit -LRB- NR1 , NR2A , NR2B -RRB- expression during the critical period in cat visual cortex .
14622581	0	NMDA	4,8	NR2B	80,84	NMDA	NR2B	CHEBI:6121	2904	Chemical	Gene	receptor|compound|START_ENTITY coupled|nsubjpass|receptor coupled|nmod|interaction interaction|nmod|END_ENTITY	The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1 .
14654094	0	NMDA	16,20	NR2B	0,4	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	windup|compound|START_ENTITY containing|dobj|windup END_ENTITY|acl|containing	NR2B containing NMDA receptor dependent windup of single spinal neurons .
14712509	0	NMDA	134,138	NR2B	61,65	NMDA	NR2B	CHEBI:6121	2904	Chemical	Gene	-RSB-|compound|START_ENTITY assembling|nmod|-RSB- study|acl|assembling deleted|nmod|study deleted|dobj|mutants mutants|nummod|END_ENTITY	-LSB- Construction of expression vectors for C-terminally deleted NR2B subunit mutants and their application in the study of assembling of NMDA receptors -RSB- .
14965239	0	NMDA	4,8	NR2B	18,22	NMDA	NR2B	CHEBI:6121	2904	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	The NMDA receptor NR2B subunit : a valid therapeutic target for multiple CNS pathologies .
14969733	0	NMDA	34,38	NR2B	48,52	NMDA	NR2B	CHEBI:6121	14812(Tax:10090)	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Changes in methylation pattern of NMDA receptor NR2B gene in cortical neurons after chronic ethanol treatment in mice .
14987468	0	NMDA	102,106	NR2B	107,111	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	The NMDA NR2B subunit-selective receptor antagonist , CP-101 ,606 , enhances the functional recovery the NMDA NR2B subunit-selective receptor and reduces brain_damage after cortical compression-induced brain_ischemia .
14987468	0	NMDA	102,106	NR2B	9,13	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY enhances|xcomp|receptor enhances|nsubj|antagonist antagonist|compound|END_ENTITY	The NMDA NR2B subunit-selective receptor antagonist , CP-101 ,606 , enhances the functional recovery the NMDA NR2B subunit-selective receptor and reduces brain_damage after cortical compression-induced brain_ischemia .
14987468	0	NMDA	4,8	NR2B	107,111	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	antagonist|compound|START_ENTITY enhances|nsubj|antagonist enhances|xcomp|receptor receptor|compound|END_ENTITY	The NMDA NR2B subunit-selective receptor antagonist , CP-101 ,606 , enhances the functional recovery the NMDA NR2B subunit-selective receptor and reduces brain_damage after cortical compression-induced brain_ischemia .
14987468	0	NMDA	4,8	NR2B	9,13	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	antagonist|compound|START_ENTITY antagonist|compound|END_ENTITY	The NMDA NR2B subunit-selective receptor antagonist , CP-101 ,606 , enhances the functional recovery the NMDA NR2B subunit-selective receptor and reduces brain_damage after cortical compression-induced brain_ischemia .
15081591	0	NMDA	65,69	NR2B	43,47	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	antagonist|compound|START_ENTITY antagonist|compound|END_ENTITY	Antiparkinsonian activity of Ro_25-6981 , a NR2B subunit specific NMDA receptor antagonist , in animal models of Parkinson 's _ disease .
15146049	0	NMDA	40,44	NR2B	14,18	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY END_ENTITY|nmod|receptors	Extrasynaptic NR2B and NR2D subunits of NMDA receptors shape ` superslow ' afterburst EPSC in rat hippocampus .
15180478	0	NMDA	20,24	NR2B	4,8	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY subtype|nmod|receptor subtype|compound|END_ENTITY	The NR2B subtype of NMDA receptor : a potential target for the treatment of alcohol_dependence .
15223297	0	NMDA	15,19	NR2B	0,4	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	,606|compound|START_ENTITY ,606|compound|END_ENTITY	NR2B selective NMDA receptor antagonist CP-101 ,606 prevents levodopa-induced motor response alterations in hemi-parkinsonian rats .
15225705	0	NMDA	33,37	NR2B	18,22	NMDA	NR2B	CHEBI:6121	14812(Tax:10090)	Chemical	Gene	antagonists|compound|START_ENTITY END_ENTITY|dobj|antagonists	Oxamides as novel NR2B selective NMDA receptor antagonists .
15284339	0	NMDA	70,74	NR2B	100,104	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY containing|nsubj|receptors containing|dobj|subunit subunit|compound|END_ENTITY	Lesion-induced enhancement of LTP in rat visual cortex is mediated by NMDA receptors containing the NR2B subunit .
15470478	0	NMDA	41,45	NR2B	55,59	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	Gene knockdown with intrathecal siRNA of NMDA receptor NR2B subunit reduces formalin-induced nociception in the rat .
15707696	0	NMDA	44,48	NR2B	58,62	NMDA	NR2B	CHEBI:6121	14812(Tax:10090)	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Role of CpG islands in the up-regulation of NMDA receptor NR2B gene expression following chronic ethanol treatment of cultured cortical neurons of mice .
15759152	0	NMDA	78,82	NR2B	73,77	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	pre-treatment|compound|START_ENTITY pre-treatment|compound|END_ENTITY	Evidence for improved performance in cognitive tasks following selective NR2B NMDA receptor antagonist pre-treatment in the rat .
15769547	0	NMDA	50,54	NR2B	35,39	NMDA	NR2B	CHEBI:6121	2904	Chemical	Gene	receptor|compound|START_ENTITY receptor|nummod|END_ENTITY	In vitro characterization of novel NR2B selective NMDA receptor antagonists .
15862890	0	NMDA	15,19	NR2B	29,33	NMDA	NR2B	CHEBI:6121	14812(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY Methylation|nmod|receptor END_ENTITY|nsubj|Methylation	Methylation of NMDA receptor NR2B gene as a function of age in the mouse brain .
15890316	0	NMDA	4,8	NR2B	18,22	NMDA	NR2B	CHEBI:6121	2904	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	The NMDA receptor NR2B subunit contributes to epileptogenesis in human cortical_dysplasia .
16141268	0	NMDA	37,41	NR2B	11,15	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Functional NR2B - and NR2D-containing NMDA receptor channels in rat substantia nigra dopaminergic neurones .
16155008	0	NMDA	116,120	NR2B	111,115	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	A positive feedback loop between glycogen_synthase_kinase_3beta and protein phosphatase 1 after stimulation of NR2B NMDA receptors in forebrain neurons .
16157352	0	NMDA	37,41	NR2B	21,25	NMDA	NR2B	CHEBI:6121	2904	Chemical	Gene	receptor|compound|START_ENTITY subunit|nmod|receptor subunit|nummod|END_ENTITY	Dual contribution of NR2B subunit of NMDA receptor and SK3 Ca -LRB- 2 + -RRB- - activated K + channel to genetic predisposition_to_anorexia_nervosa .
16190898	0	NMDA	39,43	NR2B	53,57	NMDA	NR2B	CHEBI:6121	14812(Tax:10090)	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	Fyn kinase-mediated phosphorylation of NMDA receptor NR2B subunit at Tyr1472 is essential for maintenance of neuropathic_pain .
16213709	0	NMDA	48,52	NR2B	33,37	NMDA	NR2B	CHEBI:6121	14812(Tax:10090)	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|nummod|END_ENTITY	Indole-2-carboxamidines as novel NR2B selective NMDA receptor antagonists .
16235228	0	NMDA	41,45	NR2B	17,21	NMDA	NR2B	CHEBI:6121	14812(Tax:10090)	Chemical	Gene	Ca2|compound|START_ENTITY Ca2|compound|END_ENTITY	Role of neuronal NR2B subunit-containing NMDA receptor-mediated Ca2 + influx and astrocytic activation in cultured mouse cortical neurons and astrocytes .
16307887	0	NMDA	114,118	NR2B	91,95	NMDA	NR2B	CHEBI:6121	2904	Chemical	Gene	antagonist|compound|START_ENTITY antagonist|compound|END_ENTITY	Radiosynthesis of -LRB- E -RRB- - N - -LRB- 2 - -LSB- 11C -RSB- methoxybenzyl -RRB- -3 - phenyl-acrylamidine , a novel subnanomolar NR2B subtype-selective NMDA receptor antagonist .
16319310	0	NMDA	26,30	NR2B	31,35	NMDA	NR2B	CHEBI:6121	14812(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Upregulation of forebrain NMDA NR2B receptors contributes to behavioral sensitization after inflammation .
16386794	0	NMDA	77,81	NR2B	48,52	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY subunits|nmod|receptor subunits|nummod|NR2A NR2A|compound|END_ENTITY	Perinatal exposure to PTU delays switching from NR2B to NR2A subunits of the NMDA receptor in the rat cerebellum .
16490316	0	NMDA	31,35	NR2B	36,40	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Differential expression of the NMDA NR2B receptor subunit in motoneuron populations susceptible and resistant to amyotrophic_lateral_sclerosis .
16631172	0	NMDA	28,32	NR2B	12,16	NMDA	NR2B	D016202	24410(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY containing|dobj|receptor END_ENTITY|acl|containing	The role of NR2B containing NMDA receptor in place preference conditioned with morphine and natural reinforcers in rats .
16719810	0	NMDA	61,65	NR2B	38,42	NMDA	NR2B	CHEBI:6121	2904	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|nummod|END_ENTITY	Recent advances in the development of NR2B subtype-selective NMDA receptor antagonists .
16782335	0	NMDA	53,57	NR2B	38,42	NMDA	NR2B	CHEBI:6121	14812(Tax:10090)	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|nummod|END_ENTITY	Benzimidazole-2-carboxamides as novel NR2B selective NMDA receptor antagonists .
16787405	0	NMDA	63,67	NR2B	58,62	NMDA	NR2B	CHEBI:6121	2904	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	Calpain product of WT-CRMP2 reduces the amount of surface NR2B NMDA receptor subunit .
16794574	0	NMDA	122,126	NR2B	91,95	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY phosphorylation|nmod|receptors phosphorylation|nmod|subunits subunits|compound|END_ENTITY	Reversal of cocaine-induced behavioral sensitization and associated phosphorylation of the NR2B and GluR1 subunits of the NMDA and AMPA receptors .
16866212	0	NMDA	86,90	NR2B	62,66	NMDA	NR2B	CHEBI:6121	14812(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|nummod|END_ENTITY	Implication of Src family kinase-dependent phosphorylation of NR2B subunit-containing NMDA receptor in the rewarding effect of morphine .
17020160	0	NMDA	53,57	NR2B	38,42	NMDA	NR2B	CHEBI:6121	14812(Tax:10090)	Chemical	Gene	antagonists|compound|START_ENTITY END_ENTITY|dobj|antagonists	New benzoyl_urea derivatives as novel NR2B selective NMDA receptor antagonists .
17074483	0	NMDA	46,50	NR2B	31,35	NMDA	NR2B	CHEBI:6121	2904	Chemical	Gene	antagonists|compound|START_ENTITY END_ENTITY|dobj|antagonists	Kynurenic_acid_amides as novel NR2B selective NMDA receptor antagonists .
17156360	0	NMDA	23,27	NR2B	51,55	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY switching|nmod|receptor subunits|nsubj|switching subunits|nmod|NR2A NR2A|compound|END_ENTITY	Postnatal switching of NMDA receptor subunits from NR2B to NR2A in rat facial motor neurons .
17156796	0	NMDA	23,27	NR2B	37,41	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	Changes in function of NMDA receptor NR2B subunit in spinal cord of rats with neuropathy following chronic ethanol consumption .
17447466	0	NMDA	77,81	NR2B	53,57	NMDA	NR2B	CHEBI:6121	2904	Chemical	Gene	receptor|compound|START_ENTITY receptor|nummod|END_ENTITY	Role of tyrosine kinase-dependent phosphorylation of NR2B subunit-containing NMDA receptor in morphine reward .
17849398	0	NMDA	47,51	NR2B	21,25	NMDA	NR2B	CHEBI:6121	2904	Chemical	Gene	receptor|compound|START_ENTITY domain|nmod|receptor modulatory|dobj|domain modulatory|nsubj|modeling modeling|nmod|END_ENTITY	Homology modeling of NR2B modulatory domain of NMDA receptor and analysis of ifenprodil binding .
17881524	0	NMDA	142,146	NR2B	121,125	NMDA	NR2B	CHEBI:6121	14812(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY subunits|nmod|receptor subunits|nummod|END_ENTITY	Caloric restriction increases learning consolidation and facilitates synaptic plasticity through mechanisms dependent on NR2B subunits of the NMDA receptor .
18005003	0	NMDA	0,4	NR2B	14,18	NMDA	NR2B	CHEBI:6121	14812(Tax:10090)	Chemical	Gene	increases|compound|START_ENTITY increases|nummod|END_ENTITY	NMDA receptor NR2B subunit over-expression increases cerebellar granule cell migratory activity .
18006154	0	NMDA	20,24	NR2B	4,8	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY subunit|nmod|receptors subunit|compound|END_ENTITY	The NR2B subunit in NMDA receptors is functionally important during cerebellar granule cell migration .
18033811	0	NMDA	47,51	NR2B	42,46	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	neurotransmission|compound|START_ENTITY neurotransmission|compound|END_ENTITY	Switch to Ca2 + - permeable AMPA and reduced NR2B NMDA receptor-mediated neurotransmission at dorsal horn nociceptive synapses during inflammatory_pain in the rat .
18033813	0	NMDA	35,39	NR2B	0,4	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	NR2B - and NR2D-containing synaptic NMDA receptors in developing rat substantia nigra pars compacta dopaminergic neurones .
18242021	0	NMDA	72,76	NR2B	35,39	NMDA	NR2B	CHEBI:6121	2904	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|selective selective|advmod|END_ENTITY	Solid-state characterization of an NR2B selective N-methyl_d-aspartate -LRB- NMDA -RRB- antagonist polymorphs .
18342306	0	NMDA	52,56	NR2B	37,41	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	In vivo neurochemical effects of the NR2B selective NMDA receptor antagonist CR_3394 in 6-hydroxydopamine lesioned rats .
18372311	0	NMDA	72,76	NR2B	51,55	NMDA	NR2B	D016202	14812(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY subunits|nmod|receptor subunits|compound|END_ENTITY	Functional contributions of synaptically localized NR2B subunits of the NMDA receptor to synaptic transmission and long-term potentiation in the adult mouse CNS .
18468585	0	NMDA	80,84	NR2B	63,67	NMDA	NR2B	CHEBI:6121	2904	Chemical	Gene	receptor|compound|START_ENTITY subunits|nmod|receptor subunits|nummod|END_ENTITY	Taste novelty induces intracellular redistribution of NR2A and NR2B subunits of NMDA receptor in the insular cortex .
18618247	0	NMDA	54,58	NR2B	68,72	NMDA	NR2B	CHEBI:6121	14812(Tax:10090)	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Effect of 5-azacytidine on the methylation aspects of NMDA receptor NR2B gene in the cultured cortical neurons of mice .
18685090	0	NMDA	47,51	NR2B	19,23	NMDA	NR2B	CHEBI:6121	14812(Tax:10090)	Chemical	Gene	activation|compound|START_ENTITY expression|nmod|activation expression|compound|END_ENTITY	Dual regulation of NR2B and NR2C expression by NMDA receptor activation in mouse cerebellar granule cell cultures .
18721106	0	NMDA	59,63	NR2B	14,18	NMDA	NR2B	CHEBI:6121	14812(Tax:10090)	Chemical	Gene	expression|compound|START_ENTITY alterations|nmod|expression alterations|nsubj|Inhibition Inhibition|nmod|restores restores|compound|END_ENTITY	Inhibition of NR2B phosphorylation restores alterations in NMDA receptor expression and improves functional recovery following traumatic brain_injury in mice .
18803856	0	NMDA	10,14	NR2B	15,19	NMDA	NR2B	CHEBI:6121	2904	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Cingulate NMDA NR2B receptors contribute to morphine-induced analgesic tolerance .
18809426	0	NMDA	61,65	NR2B	66,70	NMDA	NR2B	CHEBI:6121	14812(Tax:10090)	Chemical	Gene	antagonist|compound|START_ENTITY antagonist|compound|END_ENTITY	Fear memory impairing effects of systemic treatment with the NMDA NR2B subunit antagonist , Ro_25-6981 , in mice : attenuation with ageing .
18836292	0	NMDA	78,82	NR2B	42,46	NMDA	NR2B	CHEBI:6121	2904	Chemical	Gene	receptor|compound|START_ENTITY assembly|nmod|receptor subunit|nmod|assembly subunit|nsubj|Role Role|nmod|domain domain|nmod|END_ENTITY	Role of the fourth membrane domain of the NR2B subunit in the assembly of the NMDA receptor .
19427876	0	NMDA	86,90	NR2B	157,161	NMDA	NR2B	CHEBI:6121	2904	Chemical	Gene	receptors|compound|START_ENTITY inhibition|nmod|receptors conantokin-G|nmod|inhibition selectivity|nmod|conantokin-G regulated|nsubjpass|selectivity regulated|nmod|residues residues|nmod|region region|nmod|END_ENTITY	The selectivity of conantokin-G for ion channel inhibition of NR2B subunit-containing NMDA receptors is regulated by amino_acid residues in the S2 region of NR2B .
19427876	0	NMDA	86,90	NR2B	62,66	NMDA	NR2B	CHEBI:6121	2904	Chemical	Gene	receptors|compound|START_ENTITY receptors|nummod|END_ENTITY	The selectivity of conantokin-G for ion channel inhibition of NR2B subunit-containing NMDA receptors is regulated by amino_acid residues in the S2 region of NR2B .
19453375	0	NMDA	46,50	NR2B	30,34	NMDA	NR2B	CHEBI:6121	2904	Chemical	Gene	receptor|compound|START_ENTITY subunit|nmod|receptor subunit|compound|END_ENTITY	Phosphorylation status of the NR2B subunit of NMDA receptor regulates its interaction with calcium/calmodulin-dependent protein kinase II .
19596521	0	NMDA	73,77	NR2B	57,61	NMDA	NR2B	CHEBI:6121	2904	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Estradiol and the relationship between dendritic spines , NR2B containing NMDA receptors , and the magnitude of long-term potentiation at hippocampal CA3-CA1 synapses .
19726645	0	NMDA	0,4	NR2B	37,41	NMDA	NR2B	CHEBI:6121	14812(Tax:10090)	Chemical	Gene	GluN2B|compound|START_ENTITY GluN2B|appos|END_ENTITY	NMDA receptor GluN2B -LRB- GluR_epsilon_2 / NR2B -RRB- subunit is crucial for channel function , postsynaptic macromolecular organization , and actin cytoskeleton at hippocampal CA3 synapses .
19910922	0	NMDA	57,61	NR2B	71,75	NMDA	NR2B	CHEBI:6121	2904	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	Structure of the zinc-bound amino-terminal domain of the NMDA receptor NR2B subunit .
20141836	0	NMDA	23,27	NR2B	37,41	NMDA	NR2B	CHEBI:6121	14812(Tax:10090)	Chemical	Gene	subunits|compound|START_ENTITY subunits|compound|END_ENTITY	DAPK1 interaction with NMDA receptor NR2B subunits mediates brain_damage in stroke .
20427279	0	NMDA	80,84	NR2B	135,139	NMDA	NR2B	D016202	2904	Chemical	Gene	receptor|appos|START_ENTITY receptor|acl:relcl|reveals reveals|dobj|role role|nmod|END_ENTITY	Novel approach to probe subunit-specific contributions to N-methyl-D-aspartate -LRB- NMDA -RRB- receptor trafficking reveals a dominant role for NR2B in receptor recycling .
20462722	0	NMDA	119,123	NR2B	103,107	NMDA	NR2B	CHEBI:6121	2904	Chemical	Gene	receptors|compound|START_ENTITY containing|dobj|receptors END_ENTITY|xcomp|containing	Development of a selective competitive receptor binding assay for the determination of the affinity to NR2B containing NMDA receptors .
20965739	0	NMDA	44,48	NR2B	29,33	NMDA	NR2B	CHEBI:6121	14812(Tax:10090)	Chemical	Gene	antagonists|compound|START_ENTITY END_ENTITY|dep|antagonists	Conformationally constrained NR2B selective NMDA receptor antagonists derived from ifenprodil : Synthesis and biological evaluation of tetrahydro-3-benzazepine-1 ,7 - diols .
21285873	0	NMDA	115,119	NR2B	0,4	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	antagonist|compound|START_ENTITY comparison|nmod|antagonist expression|dep|comparison inhibits|dobj|expression inhibits|nsubj|Ro25-6981 Ro25-6981|nummod|END_ENTITY	NR2B subunit-specific NMDA antagonist Ro25-6981 inhibits the expression of conditioned fear : a comparison with the NMDA antagonist MK-801 and fluoxetine .
21285873	0	NMDA	22,26	NR2B	0,4	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	Ro25-6981|compound|START_ENTITY Ro25-6981|nummod|END_ENTITY	NR2B subunit-specific NMDA antagonist Ro25-6981 inhibits the expression of conditioned fear : a comparison with the NMDA antagonist MK-801 and fluoxetine .
21364640	0	NMDA	34,38	NR2B	50,54	NMDA	NR2B	CHEBI:6121	2904	Chemical	Gene	receptor|compound|START_ENTITY subunit|nmod:poss|receptor subunit|compound|END_ENTITY	CXCL12 inhibits expression of the NMDA receptor 's NR2B subunit through a histone deacetylase-dependent pathway contributing to neuronal survival .
21397592	0	NMDA	0,4	NR2B	87,91	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	expression|compound|START_ENTITY expression|dep|dominance dominance|nmod|END_ENTITY	NMDA receptor subunit expression in the supraoptic nucleus of adult rats : dominance of NR2B and NR2D .
21453995	0	NMDA	147,151	NR2B	142,146	NMDA	NR2B	CHEBI:6121	2904	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Synthesis , evaluation and metabolic studies of radiotracers containing a 4 - -LRB- 4 - -LSB- 18F -RSB- - fluorobenzyl -RRB- piperidin-1-yl moiety for the PET imaging of NR2B NMDA receptors .
21524576	0	NMDA	80,84	NR2B	51,55	NMDA	NR2B	CHEBI:6121	14812(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY antagonists|nmod|receptor antagonists|nummod|END_ENTITY	2,6-Disubstituted _ pyrazines and related analogs as NR2B site antagonists of the NMDA receptor with anti-depressant activity .
21601998	0	NMDA	16,20	NR2B	0,4	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY subunit|nmod|receptor subunit|nummod|END_ENTITY	NR2B subunit of NMDA receptor at nucleus accumbens is involved in morphine rewarding effect by siRNA study .
21848649	0	NMDA	69,73	NR2B	83,87	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Brain-derived_neurotrophic_factor-tyrosine_kinase_B pathway mediates NMDA receptor NR2B subunit phosphorylation in the supraoptic nuclei following progressive dehydration .
21880917	0	NMDA	38,42	NR2B	18,22	NMDA	NR2B	CHEBI:6121	14812(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY subunit|nmod|receptor subunit|compound|END_ENTITY	Kalirin binds the NR2B subunit of the NMDA receptor , altering its synaptic localization and function .
21955919	0	NMDA	36,40	NR2B	31,35	NMDA	NR2B	CHEBI:6121	14812(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	D4 dopamine receptors modulate NR2B NMDA receptors and LTP in stratum oriens of hippocampal CA1 .
21966384	0	NMDA	37,41	NR2B	67,71	NMDA	NR2B	CHEBI:6121	14812(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY containing|nsubj|receptors containing|dobj|subunit subunit|compound|END_ENTITY	The A-current modulates learning via NMDA receptors containing the NR2B subunit .
22001275	0	NMDA	77,81	NR2B	61,65	NMDA	NR2B	CHEBI:6121	2904	Chemical	Gene	3|compound|START_ENTITY containing|dobj|3 END_ENTITY|acl|containing	WITHDRAWN : Glutamate Attenuates IGF-1 Receptor Signaling via NR2B containing NMDA Receptors 3 and neuronal Nitric_Oxide Synthase .
22003303	0	NMDA	14,18	NR2B	9,13	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	antagonism|compound|START_ENTITY antagonism|compound|END_ENTITY	Cortical NR2B NMDA subunit antagonism reduces inflammatory_pain in male and female rats .
22137658	0	NMDA	57,61	NR2B	79,83	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Isoflurane/nitrous _ oxide anesthesia induces increases in NMDA receptor subunit NR2B protein expression in the aged rat brain .
22420360	0	NMDA	57,61	NR2B	52,56	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	antagonism|compound|START_ENTITY antagonism|compound|END_ENTITY	Reduction of inflammatory pain in female rats after NR2B NMDA cortical antagonism .
22479519	0	NMDA	77,81	NR2B	24,28	NMDA	NR2B	CHEBI:6121	2904	Chemical	Gene	receptor|compound|START_ENTITY control|nmod|receptor phosphatase-1|nmod|control regulation|nmod|phosphatase-1 regulation|nmod|END_ENTITY	Selective regulation of NR2B by protein phosphatase-1 for the control of the NMDA receptor in neuroprotection .
22543102	0	NMDA	34,38	NR2B	18,22	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY expression|nmod|receptor expression|nmod|subunit subunit|compound|END_ENTITY	The expression of NR2B subunit of NMDA receptor in the suprachiasmatic nucleus of Wistar_rats and its role in glutamate-induced CREB and ERK1/2 phosphorylation .
22610100	0	NMDA	224,228	NR2B	16,20	NMDA	NR2B	CHEBI:6121	2904	Chemical	Gene	receptor|compound|START_ENTITY affinities|nmod|receptor site|nmod|affinities identification|nmod|site Cleavage|dep|identification Cleavage|nmod|terminus terminus|nummod|END_ENTITY	Cleavage of the NR2B subunit amino terminus of N-methyl-D-aspartate -LRB- NMDA -RRB- receptor by tissue_plasminogen_activator : identification of the cleavage site and characterization of ifenprodil and glycine affinities on truncated NMDA receptor .
22610100	0	NMDA	69,73	NR2B	16,20	NMDA	NR2B	CHEBI:6121	2904	Chemical	Gene	receptor|appos|START_ENTITY terminus|nmod|receptor terminus|nummod|END_ENTITY	Cleavage of the NR2B subunit amino terminus of N-methyl-D-aspartate -LRB- NMDA -RRB- receptor by tissue_plasminogen_activator : identification of the cleavage site and characterization of ifenprodil and glycine affinities on truncated NMDA receptor .
22754048	0	NMDA	121,125	NR2B	97,101	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY containing|dobj|receptors subunit|xcomp|containing subunit|nsubj|blockade blockade|nmod|END_ENTITY	State-dependent increase of cortical gamma activity during REM sleep after selective blockade of NR2B subunit containing NMDA receptors .
22816022	0	NMDA	103,107	NR2B	80,84	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	antagonists|compound|START_ENTITY subtype-selective|dobj|antagonists subtype-selective|nsubj|Discovery Discovery|nmod|END_ENTITY	Discovery of 3-substituted_aminocyclopentanes as potent and orally bioavailable NR2B subtype-selective NMDA antagonists .
22819974	0	NMDA	60,64	NR2B	74,78	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	Repeated treatment with nicotine induces phosphorylation of NMDA receptor NR2B subunit in the brain regions involved in behavioral sensitization .
22932868	0	NMDA	88,92	NR2B	102,106	NMDA	NR2B	CHEBI:6121	14812(Tax:10090)	Chemical	Gene	expression|compound|START_ENTITY expression|nummod|END_ENTITY	Kv4 .2 potassium channels segregate to extrasynaptic domains and influence intrasynaptic NMDA receptor NR2B subunit expression .
22993256	0	NMDA	55,59	NR2B	50,54	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	Arcuate Src activation-induced phosphorylation of NR2B NMDA subunit contributes to inflammatory pain in rats .
23007637	0	NMDA	110,114	NR2B	105,109	NMDA	NR2B	CHEBI:6121	2904	Chemical	Gene	visualization|compound|START_ENTITY visualization|compound|END_ENTITY	Radiolabelling of 1,4-disubstituted _ 3 - -LSB- 18F -RSB- fluoropiperidines and its application to new radiotracers for NR2B NMDA receptor visualization .
23313317	0	NMDA	9,13	NR2B	83,87	NMDA	NR2B	CHEBI:6121	2904	Chemical	Gene	LTP|compound|START_ENTITY LTP|nmod|END_ENTITY	Enhanced NMDA receptor-dependent LTP in the epileptic CA1 area via upregulation of NR2B .
23866919	0	NMDA	78,82	NR2B	73,77	NMDA	NR2B	CHEBI:6121	14812(Tax:10090)	Chemical	Gene	subtype|compound|START_ENTITY subtype|compound|END_ENTITY	LRP1 is critical for the surface distribution and internalization of the NR2B NMDA receptor subtype .
24125810	0	NMDA	52,56	NR2B	32,36	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY subunit|nmod|receptor subunit|compound|END_ENTITY	Tyrosine phosphorylation of the NR2B subunit of the NMDA receptor in the spinal cord contributes to chronic visceral_pain in rats .
24486380	6	NMDA	925,929	NR2B	939,943	NMDA	GDNF	CHEBI:6121	14573(Tax:10090)	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	In addition , reduced expression levels of NMDA receptor NR2B subunit were reestablished .
24690172	0	NMDA	124,128	NR2B	107,111	NMDA	NR2B	CHEBI:6121	2904	Chemical	Gene	receptors|compound|START_ENTITY subunits|nmod|receptors subunits|nummod|END_ENTITY	Leptin reverses corticosterone-induced inhibition of neural stem cell proliferation through activating the NR2B subunits of NMDA receptors .
24746090	0	NMDA	70,74	NR2B	54,58	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY subunit|nmod|receptor subunit|nummod|END_ENTITY	-LSB- Effects of repeated ultrasound on expression of NR1 , NR2B subunit of NMDA receptor and synaptic structure in prenatal rats -RSB- .
24929961	0	NMDA	179,183	NR2B	155,159	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|nummod|END_ENTITY	Synthesis and preclinical evaluation of carbon-11 labelled N - -LRB- -LRB- 5 - -LRB- 4-fluoro-2 - -LSB- -LRB- 11 -RRB- C -RSB- methoxyphenyl -RRB- pyridin-3-yl -RRB- methyl -RRB- cyclopentanamine as a PET tracer for NR2B subunit-containing NMDA receptors .
25276438	0	NMDA	82,86	NR2B	58,62	NMDA	NR2B	CHEBI:6121	14812(Tax:10090)	Chemical	Gene	Receptors|compound|START_ENTITY Receptors|compound|END_ENTITY	Abeta -LRB- 1-42 -RRB- Enhances Neuronal Excitability in the CA1 via NR2B Subunit-Containing NMDA Receptors .
25896886	0	NMDA	0,4	NR2B	14,18	NMDA	NR2B	D016202	14812(Tax:10090)	Chemical	Gene	subunits|compound|START_ENTITY subunits|compound|END_ENTITY	NMDA receptor NR2B subunits contribute to PTZ-kindling-induced hippocampal astrocytosis and oxidative stress .
25896886	7	NMDA	1226,1230	NR2B	1240,1244	NMDA	NR2B	D016202	14812(Tax:10090)	Chemical	Gene	subunits|compound|START_ENTITY subunits|compound|END_ENTITY	Furthermore , blocking NMDA receptor NR2B subunits also abolished PTZ-kindling-induced BDNF expression .
26105137	0	NMDA	69,73	NR2B	49,53	NMDA	NR2B	D016202	2904	Chemical	Gene	Cognition|compound|START_ENTITY Selective|nmod|Cognition Selective|nmod|Subtype Subtype|compound|END_ENTITY	Negative Allosteric Modulators Selective for The NR2B Subtype of The NMDA Receptor Impair Cognition in Multiple Domains .
26303340	0	NMDA	136,140	NR2B	73,77	NMDA	NR2B	D016202	24410(Tax:10116)	Chemical	Gene	modulation|compound|START_ENTITY mechanism|nmod|modulation phosphorylation|dep|mechanism phosphorylation|nmod|END_ENTITY	Adenosine A2A receptors permit mGluR5-evoked tyrosine phosphorylation of NR2B -LRB- Tyr1472 -RRB- in rat hippocampus : a possible key mechanism in NMDA receptor modulation .
26515544	0	NMDA	24,28	NR2B	19,23	NMDA	NR2B	D016202	24410(Tax:10116)	Chemical	Gene	subunits|compound|START_ENTITY subunits|compound|END_ENTITY	Phosphorylation of NR2B NMDA subunits by protein kinase C in arcuate_nucleus contributes to inflammatory pain in rats .
26714288	0	NMDA	80,84	NR2B	102,106	NMDA	NR2B	D016202	14812(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY reduction|nmod|receptor results|nmod|reduction subunit|nsubj|results subunit|dobj|expression expression|nummod|END_ENTITY	Dopamine receptor D5 deficiency results in a selective reduction of hippocampal NMDA receptor subunit NR2B expression and impaired memory .
26924124	0	NMDA	63,67	NR2B	43,47	NMDA	NR2B	D016202	14812(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY subunit|nmod|receptor subunit|compound|END_ENTITY	Traxoprodil , a selective antagonist of the NR2B subunit of the NMDA receptor , potentiates the antidepressant-like effects of certain antidepressant drugs in the forced swim test in mice .
27035340	0	NMDA	32,36	NR2B	37,41	NMDA	NR2B	D016202	2904	Chemical	Gene	Modulators|compound|START_ENTITY Modulators|compound|END_ENTITY	The qEEG Signature of Selective NMDA NR2B Negative Allosteric Modulators ; A Potential Translational Biomarker for Drug Development .
9100675	0	NMDA	11,15	NR2B	39,43	NMDA	NR2B	CHEBI:6121	2904	Chemical	Gene	subunit|compound|START_ENTITY subunit|appos|NR1 NR1|dep|END_ENTITY	Changes of NMDA receptor subunit -LRB- NR1 , NR2B -RRB- and glutamate transporter -LRB- GLT1 -RRB- mRNA expression in Huntington 's _ disease -- an in situ hybridization study .
9115742	0	NMDA	52,56	NR2B	122,126	NMDA	NR2B	CHEBI:6121	2904	Chemical	Gene	subunits|compound|START_ENTITY discrimination|nmod|subunits determinants|nmod|discrimination determinants|dep|analysis analysis|nmod|site site|nmod|subunit subunit|compound|END_ENTITY	Molecular determinants of agonist discrimination by NMDA receptor subunits : analysis of the glutamate binding site on the NR2B subunit .
9384494	0	NMDA	43,47	NR2B	57,61	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	Antinociceptive activity of CP-101 ,606 , an NMDA receptor NR2B subunit antagonist .
9504387	0	NMDA	16,20	NR2B	63,67	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	antagonism|compound|START_ENTITY END_ENTITY|nsubj|antagonism	State-dependent NMDA receptor antagonism by Ro_8-4304 , a novel NR2B selective , non-competitive , voltage-independent antagonist .
9544217	0	NMDA	141,145	NR2B	118,122	NMDA	NR2B	CHEBI:6121	2904	Chemical	Gene	antagonist|compound|START_ENTITY antagonist|amod|diol diol|dep|analogue analogue|nmod|END_ENTITY	-LRB- 3R ,4 S -RRB- -3 - -LSB- 4 - -LRB- 4-fluorophenyl -RRB- -4 - hydroxypiperidin-1-yl -RSB- chroman-4 ,7 - diol : a conformationally restricted analogue of the NR2B subtype-selective NMDA antagonist -LRB- 1S ,2 S -RRB- -1 - -LRB- 4-hydroxyphenyl -RRB- -2 - -LRB- 4-hydroxy-4-phenylpiperidino -RRB- - _ 1-propanol .
9572273	0	NMDA	33,37	NR2B	17,21	NMDA	NR2B	CHEBI:6121	2904	Chemical	Gene	receptors|compound|START_ENTITY Up-regulation|nmod|receptors Up-regulation|nmod|subunit subunit|compound|END_ENTITY	Up-regulation of NR2B subunit of NMDA receptors in cerebellar granule neurons by Ca2 + / calmodulin kinase inhibitor KN93 .
9572302	0	NMDA	97,101	NR2B	123,127	NMDA	NR2B	CHEBI:6121	24410(Tax:10116)	Chemical	Gene	antagonist|nmod|START_ENTITY receptors|nsubj|antagonist receptors|xcomp|containing containing|dobj|subunits subunits|nummod|END_ENTITY	In vitro binding properties in rat brain of -LSB- 3H -RSB- Ro_25-6981 , a potent and selective antagonist of NMDA receptors containing NR2B subunits .
16221864	0	NMDA	96,100	NR2C	91,95	NMDA	NR2C	CHEBI:6121	14813(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Neuronal_depolarization controls brain-derived_neurotrophic_factor-induced upregulation of NR2C NMDA receptor via calcineurin signaling .
19477150	0	NMDA	50,54	NR2C	109,113	NMDA	NR2C	CHEBI:6121	2905	Chemical	Gene	receptors|compound|START_ENTITY trafficking|nmod|receptors kinase|nsubj|trafficking kinase|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Growth factor-dependent trafficking of cerebellar NMDA receptors via protein kinase B/Akt phosphorylation of NR2C .
20981015	0	NMDA	61,65	NR2C	35,39	NMDA	NR2C	CHEBI:6121	2905	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	A subunit-selective potentiator of NR2C - and NR2D-containing NMDA receptors .
22386206	0	NMDA	26,30	NR2C	0,4	NMDA	NR2C	CHEBI:6121	2905	Chemical	Gene	receptors|compound|START_ENTITY subunits|nmod|receptors subunits|nsubj|END_ENTITY	NR2C and NR2D subunits of NMDA receptors in frog and turtle retina .
7519658	0	NMDA	63,67	NR2C	43,47	NMDA	NR2C	CHEBI:6121	24411(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY subunit|nmod|receptor subunit|compound|END_ENTITY	In vitro hypoxia induces expression of the NR2C subunit of the NMDA receptor in rat cortex and hippocampus .
8499600	0	NMDA	48,52	NR2C	28,32	NMDA	NR2C	CHEBI:6121	24411(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY expression|nmod|receptor expression|nmod|subunit subunit|compound|END_ENTITY	Transient expression of the NR2C subunit of the NMDA receptor in developing rat brain .
8756432	0	NMDA	16,20	NR2C	95,99	NMDA	NR2C	CHEBI:6121	14813(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY Modification|nmod|channels Modification|nmod|gene gene|compound|END_ENTITY	Modification of NMDA receptor channels and synaptic transmission by targeted disruption of the NR2C gene .
9037519	0	NMDA	34,38	NR2C	48,52	NMDA	NR2C	CHEBI:6121	2905	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	Cloning of the cDNA for the human NMDA receptor NR2C subunit and its expression in the central nervous system and periphery .
15152019	0	NMDA	54,58	NR2D	18,22	NMDA	NR2D	CHEBI:6121	24412(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY block|nmod|receptor reduces|dobj|block reduces|nsubj|delivery delivery|nmod|subunits subunits|nummod|END_ENTITY	Viral delivery of NR2D subunits reduces Mg2 + block of NMDA receptor and restores NT-3-induced potentiation of AMPA-kainate responses in maturing rat motoneurons .
19309162	0	NMDA	95,99	NR2D	75,79	NMDA	NR2D	CHEBI:6121	2906	Chemical	Gene	receptor|compound|START_ENTITY subunit|nmod|receptor subunit|compound|END_ENTITY	Conantokin-Br from Conus brettinghami and selectivity determinants for the NR2D subunit of the NMDA receptor .
20153313	0	NMDA	43,47	NR2D	27,31	NMDA	NR2D	CHEBI:6121	2906	Chemical	Gene	receptor|compound|START_ENTITY subunit|nmod|receptor subunit|nummod|END_ENTITY	Expression of NR3B but not NR2D subunit of NMDA receptor in human blood lymphocytes can serve as a suitable peripheral marker for opioid_addiction studies .
7715842	0	NMDA	64,68	NR2D	106,110	NMDA	NR2D	CHEBI:6121	100126609(Tax:8355)	Chemical	Gene	properties|appos|START_ENTITY receptors|nsubj|properties receptors|xcomp|containing containing|xcomp|subunit subunit|nsubj|4 4|appos|END_ENTITY	Pharmacological properties of recombinant N-methyl-D-aspartate -LRB- NMDA -RRB- receptors containing the epsilon 4 -LRB- NR2D -RRB- subunit .
8769890	0	NMDA	41,45	NR2D	79,83	NMDA	NR2D	CHEBI:6121	24412(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY expression|nmod|receptor subtypes|nsubj|expression subtypes|xcomp|containing containing|dobj|subunit subunit|compound|END_ENTITY	Developmental and regional expression of NMDA receptor subtypes containing the NR2D subunit in rat brain .
11823786	0	NMDA	58,62	NR3	44,47	NMDA	NR3	CHEBI:6121	378537(Tax:8355)	Chemical	Gene	subunits|compound|START_ENTITY family|nmod|subunits family|compound|END_ENTITY	Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits .
14499953	0	NMDA	63,67	NR3	14,17	NMDA	NR3	CHEBI:6121	2904	Chemical	Gene	receptors|compound|START_ENTITY inhibition|nmod|receptors subunit|nmod|inhibition subunit|nsubj|Effect Effect|nmod|END_ENTITY	Effect of the NR3 subunit on ethanol inhibition of recombinant NMDA receptors .
18654865	0	NMDA	40,44	NR3	29,32	NMDA	NR3	CHEBI:6121	2904	Chemical	Gene	receptor|compound|START_ENTITY function|nsubj|receptor function|advcl|tweaks tweaks|nsubj|END_ENTITY	Shuffling the deck anew : how NR3 tweaks NMDA receptor function .
9891978	0	NMDA	73,77	NR3	54,57	NMDA	NR3	CHEBI:6121	191573(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY subunit|nmod|receptor subunit|compound|END_ENTITY	Identification of a long variant of mRNA encoding the NR3 subunit of the NMDA receptor : its regional distribution and developmental expression in the rat brain .
11929923	0	NMDA	59,63	NR3A	39,43	NMDA	NR3A	CHEBI:6121	242443(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY Characterization|nmod|receptor Characterization|nmod|subunit subunit|compound|END_ENTITY	Characterization and comparison of the NR3A subunit of the NMDA receptor in recombinant systems and primary cortical neurons .
12209845	0	NMDA	36,40	NR3A	58,62	NMDA	NR3A	CHEBI:6121	116443	Chemical	Gene	receptor|compound|START_ENTITY expression|nmod|receptor subunit|nsubj|expression subunit|dobj|END_ENTITY	Temporal and regional expression of NMDA receptor subunit NR3A in the mammalian brain .
17182766	0	NMDA	43,47	NR3A	0,4	NMDA	NR3A	CHEBI:6121	378537(Tax:8355)	Chemical	Gene	channel|compound|START_ENTITY vestibule|nmod|channel modulates|dobj|vestibule modulates|nsubj|END_ENTITY	NR3A modulates the outer vestibule of the `` NMDA '' receptor channel .
17214563	0	NMDA	46,50	NR3A	26,30	NMDA	NR3A	CHEBI:6121	116443	Chemical	Gene	receptor|compound|START_ENTITY subunit|nmod|receptor subunit|compound|END_ENTITY	Genetic variations of the NR3A subunit of the NMDA receptor modulate prefrontal cerebral activity in humans .
17617428	0	NMDA	29,33	NR3A	15,19	NMDA	NR3A	CHEBI:6121	116443	Chemical	Gene	receptors|compound|START_ENTITY END_ENTITY|nmod|receptors	On the role of NR3A in human NMDA receptors .
17997397	0	NMDA	51,55	NR3A	12,16	NMDA	NR3A	CHEBI:6121	116443	Chemical	Gene	receptors|compound|START_ENTITY subunits|nmod|receptors subunits|nsubj|Analysis Analysis|nmod|receptor receptor|compound|END_ENTITY	Analysis of NR3A receptor subunits in human native NMDA receptors .
19386922	0	NMDA	43,47	NR3A	23,27	NMDA	NR3A	CHEBI:6121	242443(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY Neuroprotection|nmod|receptor Neuroprotection|nmod|subunit subunit|compound|END_ENTITY	Neuroprotection by the NR3A subunit of the NMDA receptor .
19386922	8	NMDA	1141,1145	NR3A	1203,1207	NMDA	NR3A	CHEBI:6121	242443(Tax:10090)	Chemical	Gene	injection|nmod|START_ENTITY adulthood|appos|injection persist|nmod|adulthood location|acl:relcl|persist killed|nsubj|location killed|nmod|KO KO|compound|END_ENTITY	In adult retina , one location where high levels of NR3A normally persist into adulthood , injection of NMDA into the eye killed more retinal ganglion cells in adult NR3A KO than WT mice .
20097255	0	NMDA	33,37	NR3A	17,21	NMDA	NR3A	CHEBI:6121	116443	Chemical	Gene	functions|compound|START_ENTITY Influence|nmod|functions Influence|nmod|subunit subunit|compound|END_ENTITY	Influence of the NR3A subunit on NMDA receptor functions .
26334321	0	NMDA	18,22	NR3A	48,52	NMDA	NR3A	D016202	242443(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY Expression|nmod|receptor subunit|nsubj|Expression subunit|dobj|GluN3A GluN3A|appos|END_ENTITY	Expression of the NMDA receptor subunit GluN3A -LRB- NR3A -RRB- in the olfactory system and its regulatory role on olfaction in the adult mouse .
9620802	0	NMDA	10,14	NR3A	83,87	NMDA	NR3A	CHEBI:6121	242443(Tax:10090)	Chemical	Gene	current|compound|START_ENTITY END_ENTITY|nsubj|current	Increased NMDA current and spine density in mice lacking the NMDA_receptor subunit NR3A .
26237972	0	NMDA	78,82	NR_2_B	60,66	NMDA	NR 2 B	D016202	24410(Tax:10116)	Chemical	Gene	Receptor|compound|START_ENTITY Subunit|nmod|Receptor Subunit|compound|END_ENTITY	-LSB- Effect of Electroacupuncture Intervention on Expression of NR_2_B Subunit of NMDA Receptor in Amygdala during Morphine Withdrawal in Rats -RSB- .
19243221	0	NMDA	28,32	Neto1	0,5	NMDA	Neto1	CHEBI:6121	246317(Tax:10090)	Chemical	Gene	protein|compound|START_ENTITY protein|nsubj|END_ENTITY	Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning .
10541467	0	NMDA	23,27	Orphanin_FQ	0,11	NMDA	Orphanin FQ	CHEBI:6121	18155(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|suppresses suppresses|amod|END_ENTITY	Orphanin_FQ suppresses NMDA receptor-dependent long-term depression and depotentiation in hippocampal dentate gyrus .
19780893	0	NMDA	39,43	PINK1	14,19	NMDA	PINK1	CHEBI:6121	65018	Chemical	Gene	receptors|compound|START_ENTITY Regulation|nmod|receptors Regulation|nmod|END_ENTITY	Regulation of PINK1 by NR2B-containing NMDA receptors in ischemic_neuronal_injury .
19495967	0	NMDA	144,148	PSD-95	137,143	NMDA	PSD-95	CHEBI:6121	1742	Chemical	Gene	interaction|compound|START_ENTITY interaction|compound|END_ENTITY	Detecting protein-protein interactions in living cells : development of a bioluminescence resonance energy transfer assay to evaluate the PSD-95 / NMDA receptor interaction .
15629704	0	NMDA	0,4	Rab5	55,59	NMDA	Rab5	CHEBI:6121	5868	Chemical	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	NMDA receptor-dependent activation of the small GTPase Rab5 drives the removal of synaptic AMPA receptors during hippocampal LTD. .
16148228	0	NMDA	17,21	Reelin	0,6	NMDA	Reelin	CHEBI:6121	5649	Chemical	Gene	activity|compound|START_ENTITY modulates|dobj|activity modulates|nsubj|END_ENTITY	Reelin modulates NMDA receptor activity in cortical neurons .
18331582	0	NMDA	47,51	Rho	72,75	NMDA	Rho	CHEBI:6121	6010	Chemical	Gene	protein|amod|START_ENTITY protein|compound|END_ENTITY	Regulation of dendritic spine morphology by an NMDA receptor-associated Rho GTPase-activating protein , p250GAP .
25434386	0	NMDA	19,23	S1303	30,35	NMDA	S1303	CHEBI:6121	1077684(Tax:198215)	Chemical	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of NMDA 2B at S1303 in human glioma peritumoral tissue : implications for glioma epileptogenesis .
26895301	0	NMDA	45,49	Spermine_Oxidase	68,84	NMDA	Spermine Oxidase	D016202	54498	Chemical	Gene	Activation|compound|START_ENTITY Activation|compound|END_ENTITY	HIV-Tat Induces the Nrf2/ARE Pathway through NMDA Receptor-Elicited Spermine_Oxidase Activation in Human Neuroblastoma Cells .
10531471	0	NMDA	20,24	Src	0,3	NMDA	Src	CHEBI:6121	6714	Chemical	Gene	receptors|compound|START_ENTITY potentiation|nmod|receptors potentiation|compound|END_ENTITY	Src potentiation of NMDA receptors in hippocampal and spinal neurons is not mediated by reducing zinc inhibition .
11399432	0	NMDA	0,4	Src	28,31	NMDA	Src	CHEBI:6121	6714	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	NMDA receptor regulation by Src kinase signalling in excitatory synaptic transmission and plasticity .
12618293	0	NMDA	86,90	Src	116,119	NMDA	Src	CHEBI:6121	83805(Tax:10116)	Chemical	Gene	subunit|compound|START_ENTITY interactions|nmod|subunit regulation|nmod|interactions participate|nmod|regulation phosphatase|xcomp|participate phosphatase|nsubj|2A 2A|nmod|END_ENTITY	Tyrosine kinase and tyrosine phosphatase participate in regulation of interactions of NMDA receptor subunit 2A with Src and Fyn mediated by PSD-95 after transient brain_ischemia .
14507968	0	NMDA	27,31	Src	107,110	NMDA	Src	CHEBI:6121	83805(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|family family|compound|END_ENTITY	Interleukin-1beta enhances NMDA receptor-mediated intracellular calcium increase through activation of the Src family of kinases .
15069201	0	NMDA	43,47	Src	27,30	NMDA	Src	CHEBI:6121	6714	Chemical	Gene	receptors|compound|START_ENTITY anchoring|nmod|receptors anchoring|nmod|END_ENTITY	Unique domain anchoring of Src to synaptic NMDA receptors via the mitochondrial protein NADH_dehydrogenase_subunit_2 .
15564576	0	NMDA	163,167	Src	104,107	NMDA	Src	CHEBI:6121	83805(Tax:10116)	Chemical	Gene	injection|compound|START_ENTITY triggered|nmod|injection triggered|nsubj|mechanisms mechanisms|acl|underlying underlying|dobj|stimulation stimulation|dep|contributions contributions|nmod|kinases kinases|compound|END_ENTITY	Lateral hypothalamic signaling mechanisms underlying feeding stimulation : differential contributions of Src family tyrosine kinases to feeding triggered either by NMDA injection or by food deprivation .
16339032	0	NMDA	14,18	Src	150,153	NMDA	Src	CHEBI:6121	20779(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY Modulation|nmod|receptors requires|nsubj|Modulation requires|dobj|G_alpha_q G_alpha_q|nmod|END_ENTITY	Modulation of NMDA receptors by pituitary_adenylate_cyclase_activating_peptide in CA1 neurons requires G_alpha_q , protein_kinase_C , and activation of Src .
16990796	0	NMDA	65,69	Src	54,57	NMDA	Src	CHEBI:6121	6714	Chemical	Gene	complex|compound|START_ENTITY END_ENTITY|nmod|complex	PSD-95 is a negative regulator of the tyrosine kinase Src in the NMDA receptor complex .
19011637	0	NMDA	74,78	Src	61,64	NMDA	Src	CHEBI:6121	6714	Chemical	Gene	receptor|compound|START_ENTITY uncoupling|nmod|receptor uncoupling|dobj|END_ENTITY	Treatment of inflammatory and neuropathic_pain by uncoupling Src from the NMDA receptor complex .
21441918	0	NMDA	87,91	Src	67,70	NMDA	Src	CHEBI:6121	6714	Chemical	Gene	receptors|compound|START_ENTITY upregulation|nmod|receptors upregulation|compound|END_ENTITY	Schizophrenia susceptibility pathway neuregulin 1-ErbB4 suppresses Src upregulation of NMDA receptors .
21712388	0	NMDA	98,102	Src	10,13	NMDA	Src	CHEBI:6121	6714	Chemical	Gene	N-methyl-D-aspartic_acid|dep|START_ENTITY protein|amod|N-methyl-D-aspartic_acid C-terminal_domain|nmod|protein kinase|nmod|C-terminal_domain kinase|nsubj|Effect Effect|nmod|END_ENTITY	Effect of Src kinase phosphorylation on disordered C-terminal_domain of N-methyl-D-aspartic_acid -LRB- NMDA -RRB- receptor subunit GluN2B protein .
21985289	0	NMDA	33,37	Src	13,16	NMDA	Src	CHEBI:6121	6714	Chemical	Gene	activity|compound|START_ENTITY upregulation|nmod|activity upregulation|compound|END_ENTITY	Dysregulated Src upregulation of NMDA receptor activity : a common link in chronic_pain and schizophrenia .
22105860	7	NMDA	1801,1805	Src	1640,1643	NMDA	Src	CHEBI:6121	83805(Tax:10116)	Chemical	Gene	protection|compound|START_ENTITY attenuated|dobj|protection indicated|ccomp|attenuated indicated|nsubjpass|role role|nmod|activity activity|compound|END_ENTITY	The essential role of Src activity in the protective mechanism was further indicated by the demonstration that decreasing Src activation level by the Src inhibitor PP2 attenuated the NMDA preconditioning-induced protection .
22993256	0	NMDA	55,59	Src	8,11	NMDA	Src	CHEBI:6121	83805(Tax:10116)	Chemical	Gene	subunit|compound|START_ENTITY phosphorylation|nmod|subunit phosphorylation|compound|END_ENTITY	Arcuate Src activation-induced phosphorylation of NR2B NMDA subunit contributes to inflammatory pain in rats .
25128699	0	NMDA	112,116	Src	9,12	NMDA	Src	CHEBI:6121	20779(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY signaling|dep|receptors signaling|compound|END_ENTITY	Impaired Src signaling and post-synaptic actin polymerization in Alzheimer 's _ disease mice hippocampus - Linking NMDA receptors and the reelin pathway .
26854804	0	NMDA	13,17	Src	45,48	NMDA	Src	D016202	6714	Chemical	Gene	signaling|compound|START_ENTITY couples|nsubj|signaling couples|dobj|kinases kinases|compound|END_ENTITY	Metabotropic NMDA receptor signaling couples Src family kinases to pannexin-1 during excitotoxicity .
9005855	0	NMDA	0,4	Src	70,73	NMDA	Src	CHEBI:6121	6714	Chemical	Gene	regulation|compound|START_ENTITY tyrosine|nsubj|regulation tyrosine|dobj|END_ENTITY	NMDA channel regulation by channel-associated protein tyrosine kinase Src .
9774140	0	NMDA	27,31	Src	0,3	NMDA	Src	CHEBI:6121	6714	Chemical	Gene	N-methyl-D-aspartate|appos|START_ENTITY N-methyl-D-aspartate|compound|END_ENTITY	Src , N-methyl-D-aspartate -LRB- NMDA -RRB- receptors , and synaptic plasticity .
25749299	0	NMDA	35,39	TAAR1	0,5	NMDA	TAAR1	D016202	111174(Tax:10090)	Chemical	Gene	Function|compound|START_ENTITY Function|compound|END_ENTITY	TAAR1 Modulates Cortical Glutamate NMDA Receptor Function .
22526419	0	NMDA	48,52	TDP-43	22,28	NMDA	TDP-43	CHEBI:6121	230908(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY Regulation|nmod|receptors Regulation|nmod|END_ENTITY	Regulation of nuclear TDP-43 by NR2A-containing NMDA receptors and PTEN .
17241124	0	NMDA	39,43	Tumor_necrosis_factor_alpha	0,27	NMDA	Tumor necrosis factor alpha	CHEBI:6121	21926(Tax:10090)	Chemical	Gene	activity|compound|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	Tumor_necrosis_factor_alpha stimulates NMDA receptor activity in mouse cortical neurons resulting in ERK-dependent death .
21804034	0	NMDA	15,19	VEGF	0,4	NMDA	VEGF	CHEBI:6121	7422	Chemical	Gene	activity|compound|START_ENTITY modulates|dobj|activity modulates|nsubj|END_ENTITY	VEGF modulates NMDA receptors activity in cerebellar granule cells through Src-family kinases before synapse formation .
8390208	0	NMDA	60,64	alpha-MSH	39,48	NMDA	alpha-MSH	CHEBI:6121	5443	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|potentiation potentiation|nmod|END_ENTITY	Long-term potentiation of hypothalamic alpha-MSH release by NMDA .
17602661	0	NMDA	39,43	alpha-actinin	16,29	NMDA	alpha-actinin	CHEBI:6121	87	Chemical	Gene	domain|compound|START_ENTITY END_ENTITY|nmod|domain	Displacement of alpha-actinin from the NMDA receptor NR1 C0 domain By Ca2 + / calmodulin promotes CaMKII binding .
10203239	0	NMDA	44,48	c-Fos	16,21	NMDA	c-Fos	CHEBI:6121	314322(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Hypoxia induces c-Fos protein expression in NMDA but not AMPA_glutamate receptor labeled neurons within the nucleus tractus solitarii of the conscious rat .
10408246	0	NMDA	11,15	c-Fos	62,67	NMDA	c-Fos	CHEBI:6121	314322(Tax:10116)	Chemical	Gene	antagonists|compound|START_ENTITY Effects|nmod|antagonists Effects|dep|study study|amod|END_ENTITY	Effects of NMDA receptor antagonists on morphine tolerance : a c-Fos study in the lumbar spinal cord of the rat .
10534605	0	NMDA	4,8	c-Fos	47,52	NMDA	c-Fos	CHEBI:6121	314322(Tax:10116)	Chemical	Gene	MK-801|compound|START_ENTITY attenuates|nsubj|MK-801 attenuates|dobj|expression expression|amod|END_ENTITY	The NMDA receptor antagonist MK-801 attenuates c-Fos expression in the lumbosacral spinal cord following repetitive noxious and non-noxious colorectal_distention .
11814424	0	NMDA	119,123	c-Fos	17,22	NMDA	c-Fos	CHEBI:6121	14281(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY mediated|nmod|receptors mediated|nsubjpass|expression expression|amod|END_ENTITY	Ketamine-induced c-Fos expression in the mouse posterior cingulate and retrosplenial cortices is mediated not only via NMDA receptors but also via sigma receptors .
12135782	0	NMDA	24,28	c-Fos	65,70	NMDA	c-Fos	CHEBI:6121	314322(Tax:10116)	Chemical	Gene	antagonists|compound|START_ENTITY effects|nmod|antagonists effects|nmod|END_ENTITY	Differential effects of NMDA and AMPA/KA receptor antagonists on c-Fos or Zif/268 expression in the rat spinal dorsal horn induced by noxious thermal or mechanical stimulation , or formalin injection .
12725847	0	NMDA	134,138	c-Fos	162,167	NMDA	c-Fos	CHEBI:6121	314322(Tax:10116)	Chemical	Gene	antagonist|compound|START_ENTITY HA966|appos|antagonist HA966|dep|study study|amod|END_ENTITY	Antinociceptive effects of RB101 -LRB- S -RRB- , a complete inhibitor of enkephalin-catabolizing enzymes , are enhanced by -LRB- + -RRB- - HA966 , a functional NMDA receptor antagonist : a c-Fos study in the rat spinal cord .
14534245	0	NMDA	40,44	c-Fos	100,105	NMDA	c-Fos	CHEBI:6121	14281(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|plasticity plasticity|nmod|mice mice|acl|lacking lacking|dobj|END_ENTITY	Impaired long-term memory and NR2A-type NMDA receptor-dependent synaptic plasticity in mice lacking c-Fos in the CNS .
15482902	0	NMDA	0,4	c-Fos	47,52	NMDA	c-Fos	CHEBI:6121	2353	Chemical	Gene	receptors|compound|START_ENTITY involved|nsubjpass|receptors involved|nmod|expression expression|amod|END_ENTITY	NMDA and AMPA/KA receptors are involved in the c-Fos expression following mustard oil activation of C-fibres .
19638253	0	NMDA	42,46	c-Fos	13,18	NMDA	c-Fos	CHEBI:6121	2353	Chemical	Gene	antagonists|compound|START_ENTITY induction|nmod|antagonists induction|nsubj|END_ENTITY	Differential c-Fos induction by different NMDA receptor antagonists with antidepressant efficacy : potential clinical implications .
23093008	0	NMDA	18,22	c-Fos	72,77	NMDA	c-Fos	CHEBI:6121	314322(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY blockade|nmod|receptors increases|nsubj|blockade increases|dobj|expression expression|amod|END_ENTITY	Local blockade of NMDA receptors in the rat prefrontal cortex increases c-Fos expression in multiple subcortical regions .
26995729	0	NMDA	96,100	c-Fos	60,65	NMDA	c-Fos	D016202	14281(Tax:10090)	Chemical	Gene	antagonists|compound|START_ENTITY induced|nmod|antagonists pattern|acl|induced pattern|amod|END_ENTITY	Puberty marks major changes in the hippocampal and cortical c-Fos activation pattern induced by NMDA receptor antagonists .
8564229	0	NMDA	20,24	c-Fos	55,60	NMDA	c-Fos	CHEBI:6121	2353	Chemical	Gene	receptor|compound|START_ENTITY contribution|nmod|receptor activation|nsubj|contribution activation|nmod|expression expression|amod|END_ENTITY	The contribution of NMDA receptor activation to spinal c-Fos expression in a model of inflammatory_pain .
9622652	0	NMDA	20,24	c-Fos	0,5	NMDA	c-Fos	CHEBI:6121	314322(Tax:10116)	Chemical	Gene	neurons|compound|START_ENTITY expression|nmod|neurons expression|amod|END_ENTITY	c-Fos expression in NMDA receptor-contained neurons in spinal cord in a rat model of inflammation : a double immunocytochemical study .
10760358	0	NMDA	38,42	c-fos	97,102	NMDA	c-fos	CHEBI:6121	314322(Tax:10116)	Chemical	Gene	antagonist|compound|START_ENTITY CP-101|appos|antagonist inhibits|nsubj|CP-101 inhibits|dobj|NMDA NMDA|acl|induced induced|dobj|expression expression|amod|END_ENTITY	CP-101 ,606 , an NR2B subunit selective NMDA receptor antagonist , inhibits NMDA and injury induced c-fos expression and cortical spreading depression in rodents .
10760358	0	NMDA	73,77	c-fos	97,102	NMDA	c-fos	CHEBI:6121	314322(Tax:10116)	Chemical	Gene	START_ENTITY|acl|induced induced|dobj|expression expression|amod|END_ENTITY	CP-101 ,606 , an NR2B subunit selective NMDA receptor antagonist , inhibits NMDA and injury induced c-fos expression and cortical spreading depression in rodents .
12184990	0	NMDA	40,44	c-fos	64,69	NMDA	c-fos	CHEBI:6121	314322(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY _|nmod|receptor _|nmod|expression expression|amod|END_ENTITY	NK -LRB- 1 -RRB- _ receptor and its interaction with NMDA receptor in spinal c-fos expression after lower urinary tract irritation .
12576146	0	NMDA	16,20	c-fos	67,72	NMDA	c-fos	CHEBI:6121	314322(Tax:10116)	Chemical	Gene	antagonists|compound|START_ENTITY moderate|nsubj|antagonists moderate|dobj|expression expression|amod|END_ENTITY	Non-competitive NMDA receptor antagonists moderate seizure-induced c-fos expression in the rat cerebral cortex .
1346165	0	NMDA	20,24	c-fos	149,154	NMDA	c-fos	CHEBI:6121	314322(Tax:10116)	Chemical	Gene	blockade|compound|START_ENTITY effects|nmod|blockade effects|dep|relationship relationship|nmod|expression expression|amod|END_ENTITY	Opposite effects of NMDA receptor blockade on dopaminergic D1 - and D2-mediated behavior in the 6-hydroxydopamine model of turning : relationship with c-fos expression .
1827611	0	NMDA	24,28	c-fos	47,52	NMDA	c-fos	CHEBI:6121	2353	Chemical	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Global_ischemia induces NMDA receptor-mediated c-fos expression in neurons resistant to injury in gerbil hippocampus .
1831151	0	NMDA	122,126	c-fos	9,14	NMDA	c-fos	CHEBI:6121	314322(Tax:10116)	Chemical	Gene	activation|compound|START_ENTITY importance|nmod|activation END_ENTITY|dep|importance	Striatal c-fos induction by drugs and stress in neonatally dopamine-depleted rats given nigral transplants : importance of NMDA activation and relevance to sensitization phenomena .
1912456	0	NMDA	36,40	c-fos	22,27	NMDA	c-fos	CHEBI:6121	2353	Chemical	Gene	mRNA|nmod|START_ENTITY mRNA|amod|END_ENTITY	Regional induction of c-fos mRNA by NMDA : a quantitative in-situ hybridization study .
19912927	0	NMDA	20,24	c-fos	75,80	NMDA	c-fos	CHEBI:6121	314322(Tax:10116)	Chemical	Gene	Antagonists|compound|START_ENTITY Effects|nmod|Antagonists END_ENTITY|nsubj|Effects	Regional Effects of NMDA Receptor Antagonists on the Induction of Striatal c-fos by Fenfluramine .
2156188	0	NMDA	25,29	c-fos	65,70	NMDA	c-fos	CHEBI:6121	314322(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY antagonist|nmod|receptors MK-801|appos|antagonist inhibits|nsubj|MK-801 inhibits|dobj|accumulation accumulation|amod|END_ENTITY	MK-801 , an antagonist of NMDA receptors , inhibits injury-induced c-fos protein accumulation in rat brain .
7624831	0	NMDA	0,4	c-fos	37,42	NMDA	c-fos	CHEBI:6121	314322(Tax:10116)	Chemical	Gene	antagonists|compound|START_ENTITY block|nsubj|antagonists block|dobj|expression expression|amod|END_ENTITY	NMDA antagonists and clonidine block c-fos expression during morphine withdrawal .
7707864	0	NMDA	124,128	c-fos	153,158	NMDA	c-fos	CHEBI:6121	314322(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY involved|nsubjpass|receptor involved|nmod|expression expression|amod|END_ENTITY	Expression of c-fos mRNA after cortical ablation in rat brain is modulated by basic_fibroblast_growth_factor -LRB- bFGF -RRB- and the NMDA receptor is involved in c-fos expression .
7755894	0	NMDA	0,4	c-fos	43,48	NMDA	c-fos	CHEBI:6121	2353	Chemical	Gene	receptors|compound|START_ENTITY mediate|nsubj|receptors mediate|dobj|induction induction|nmod|genes genes|amod|END_ENTITY	NMDA and D1 receptors mediate induction of c-fos and junB genes in striatum following morphine administration : implications for studies of memory .
7984041	0	NMDA	137,141	c-fos	13,18	NMDA	c-fos	CHEBI:6121	2353	Chemical	Gene	stimulation|compound|START_ENTITY levels|nmod|stimulation responsible|nmod|levels responsible|nsubj|Induction Induction|nmod|expression expression|amod|END_ENTITY	Induction of c-fos gene expression is not responsible for increased proenkephalin mRNA levels in the hippocampal dentate gyrus following NMDA stimulation .
8015382	0	NMDA	0,4	c-fos	126,131	NMDA	c-fos	CHEBI:6121	2353	Chemical	Gene	excitoprotection|compound|START_ENTITY fails|nsubj|excitoprotection fails|xcomp|alter alter|dobj|expression expression|nmod|mRNAs mRNAs|amod|END_ENTITY	NMDA receptor-mediated excitoprotection of cultured cerebellar granule neurons fails to alter glutamate-induced expression of c-fos and c-jun mRNAs .
8414186	0	NMDA	4,8	c-fos	70,75	NMDA	c-fos	CHEBI:6121	14281(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY reduces|nsubj|receptor reduces|dobj|induction induction|nmod|gene gene|amod|END_ENTITY	The NMDA receptor antagonist MK-801 markedly reduces the induction of c-fos gene by haloperidol in the mouse striatum .
8420627	0	NMDA	72,76	c-fos	39,44	NMDA	c-fos	CHEBI:6121	314322(Tax:10116)	Chemical	Gene	antagonists|compound|START_ENTITY inhibited|nmod|antagonists inhibited|nsubjpass|expression expression|nmod|END_ENTITY	Cocaine-induced expression of striatal c-fos in the rat is inhibited by NMDA receptor antagonists .
8427701	4	NMDA	690,694	c-fos	737,742	NMDA	c-fos	CHEBI:6121	2353	Chemical	Gene	START_ENTITY|nmod|mRNA mRNA|amod|END_ENTITY	Structurally distinct inhibitors of phospholipase_A2 and cyclooxygenase abolished NMDA -- but not kainic_acid-induced increases of c-fos mRNA .
8928931	0	NMDA	8,12	c-fos	59,64	NMDA	c-fos	CHEBI:6121	314322(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY glutamatergic|nsubj|Role glutamatergic|nmod|expression expression|amod|END_ENTITY	Role of NMDA and AMPA glutamatergic transmission in spinal c-fos expression after urinary tract irritation .
8987741	0	NMDA	38,42	c-fos	74,79	NMDA	c-fos	CHEBI:6121	2353	Chemical	Gene	induction|compound|START_ENTITY induction|nmod|mRNA mRNA|amod|END_ENTITY	Prostaglandin_F2alpha is required for NMDA receptor-mediated induction of c-fos mRNA in dentate gyrus neurons .
9051783	0	NMDA	74,78	c-fos	22,27	NMDA	c-fos	CHEBI:6121	2353	Chemical	Gene	receptors|compound|START_ENTITY mediated|nmod|receptors mediated|nsubjpass|induction induction|nmod|END_ENTITY	Cortical induction of c-fos by intrastriatal endothelin-1 is mediated via NMDA receptors .
9121674	0	NMDA	11,15	c-fos	69,74	NMDA	c-fos	CHEBI:6121	314322(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY contribute|nsubj|receptors contribute|xcomp|activation activation|nmod|nociceptors nociceptors|dep|study study|amod|END_ENTITY	Peripheral NMDA receptors contribute to activation of nociceptors : a c-fos expression study in rats .
9696479	0	NMDA	4,8	c-fos	62,67	NMDA	c-fos	CHEBI:6121	314322(Tax:10116)	Chemical	Gene	MK-801|compound|START_ENTITY reduces|nsubj|MK-801 reduces|dobj|expression expression|amod|END_ENTITY	The NMDA receptor antagonist MK-801 reduces capsaicin-induced c-fos expression within rat trigeminal nucleus caudalis .
23889203	0	NMDA	144,148	ca1	75,78	NMDA	ca1	CHEBI:6121	310218(Tax:10116)	Chemical	Gene	manner|compound|START_ENTITY withdrawal|nmod|manner sensitize|nmod|withdrawal sensitize|dobj|cells cells|nummod|END_ENTITY	Long-term ethanol and corticosterone co-exposure sensitize the hippocampal ca1 region pyramidal cells to insult during ethanol withdrawal in an NMDA GluN2B subunit-dependent manner .
26174743	0	NMDA	37,41	casein_kinase-1	11,26	NMDA	casein kinase-1	D016202	113927(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|modulates modulates|amod|END_ENTITY	Endogenous casein_kinase-1 modulates NMDA receptor activity of hypothalamic presympathetic neurons and sympathetic outflow in hypertension .
26174743	0	NMDA	37,41	casein_kinase-1	11,26	NMDA	casein kinase-1	D016202	113927(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|modulates modulates|amod|END_ENTITY	Endogenous casein_kinase-1 modulates NMDA receptor activity of hypothalamic presympathetic neurons and sympathetic outflow in hypertension .
16153713	0	NMDA	10,14	caspase-3	54,63	NMDA	caspase-3	CHEBI:6121	12367(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|release release|amod|END_ENTITY	Effect of NMDA on staurosporine-induced activation of caspase-3 and LDH release in mouse neocortical and hippocampal cells .
15857708	0	NMDA	83,87	cyclic_amp_response_element-binding_protein	148,191	NMDA	cyclic amp response element-binding protein	CHEBI:6121	81646(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Food restriction increases NMDA receptor-mediated calcium-calmodulin kinase II and NMDA receptor/extracellular signal-regulated kinase 1/2-mediated cyclic_amp_response_element-binding_protein phosphorylation in nucleus accumbens upon D-1 dopamine receptor stimulation in rats .
10555109	1	NMDA	177,181	gp120	228,233	NMDA	gp120	CHEBI:6121	3700	Chemical	Gene	receptor|appos|START_ENTITY Activation|nmod|receptor Activation|appos|END_ENTITY	Activation of the N-methyl-D-aspartate -LRB- NMDA -RRB- receptor by HIV-1 envelope glycoprotein_120 -LRB- gp120 -RRB- is thought to represent at least one of the pathways causing neuronal_damage in AIDS patients .
10971626	0	NMDA	89,93	gp120	23,28	NMDA	gp120	CHEBI:6121	155971(Tax:11676)	Chemical	Gene	receptors|compound|START_ENTITY activate|dobj|receptors activate|nsubj|END_ENTITY	The HIV-1 coat protein gp120 and some of its fragments potently activate native cerebral NMDA receptors mediating neuropeptide release .
16887807	0	NMDA	109,113	gp120	31,36	NMDA	gp120	CHEBI:6121	3700	Chemical	Gene	receptors|compound|START_ENTITY phosphorylation|nmod|receptors released|nmod|phosphorylation released|nmod|death death|amod|neural neural|nmod:npmod|drives drives|nummod|END_ENTITY	Interleukin-1_beta released by gp120 drives neural death through tyrosine phosphorylation and trafficking of NMDA receptors .
22114277	0	NMDA	107,111	gp120	46,51	NMDA	gp120	CHEBI:6121	3700	Chemical	Gene	receptors|compound|START_ENTITY clustering|nmod|receptors promotes|dobj|clustering promotes|nsubj|END_ENTITY	The human_immunodeficiency_virus coat protein gp120 promotes forward trafficking and surface clustering of NMDA receptors in membrane microdomains .
22795399	0	NMDA	56,60	gp120	6,11	NMDA	gp120	CHEBI:6121	3700	Chemical	Gene	receptor|compound|START_ENTITY cardiomyocytes|nmod|receptor induces|nmod|cardiomyocytes induces|nsubj|END_ENTITY	HIV-1 gp120 induces autophagy in cardiomyocytes via the NMDA receptor .
7582109	0	NMDA	125,129	gp120	12,17	NMDA	gp120	CHEBI:6121	155971(Tax:11676)	Chemical	Gene	followed|nmod|START_ENTITY culture|acl|followed arachidonic_acid|nmod|culture neurotoxicity|amod|arachidonic_acid release|nmod|neurotoxicity induces|nsubj|release induces|dep|Exposure Exposure|nmod|END_ENTITY	Exposure to gp120 of HIV-1 induces an increased release of arachidonic_acid in rat primary neuronal cell culture followed by NMDA receptor-mediated neurotoxicity .
8581564	0	NMDA	83,87	gp120	61,66	NMDA	gp120	CHEBI:6121	155971(Tax:11676)	Chemical	Gene	antagonists|amod|START_ENTITY prevented|nmod|antagonists prevented|nsubjpass|Death Death|nmod|cells cells|acl|induced induced|nmod|HIV-1 HIV-1|nummod|END_ENTITY	Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric_oxide and cyclooxygenase .
21459761	0	NMDA	37,41	growth_hormone_receptor	65,88	NMDA	growth hormone receptor	CHEBI:6121	14600(Tax:10090)	Chemical	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	The effects of aging and genotype on NMDA receptor expression in growth_hormone_receptor knockout -LRB- GHRKO -RRB- mice .
14651810	0	NMDA	54,58	mGluR1	79,85	NMDA	mGluR1	CHEBI:6121	14799(Tax:10090)	Chemical	Gene	current|compound|START_ENTITY enhancement|nmod|current enhancement|nmod|END_ENTITY	Modulation of stretch-induced enhancement of neuronal NMDA receptor current by mGluR1 depends upon presence of glia .
18248625	0	NMDA	56,60	mGluR1	0,6	NMDA	mGluR1	CHEBI:6121	14799(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY phosphorylation|nmod|receptor decreases|dobj|phosphorylation decreases|nsubj|antagonist antagonist|amod|END_ENTITY	mGluR1 antagonist decreases tyrosine phosphorylation of NMDA receptor and attenuates infarct size after transient focal cerebral_ischemia .
22362014	0	NMDA	99,103	mGluR1	91,97	NMDA	mGluR1	CHEBI:6121	14799(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Effects of exposure to low-level lead on spatial learning and memory and the expression of mGluR1 , NMDA receptor in different developmental stages of rats .
10846156	0	NMDA	55,59	mLin-10	44,51	NMDA	mLin-10	CHEBI:6121	57267(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|nmod|transport	Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport .
17234578	0	NMDA	59,63	mTOR	177,181	NMDA	mTOR	CHEBI:6121	21977(Tax:10090)	Chemical	Gene	changes|compound|START_ENTITY transporters|dobj|changes transporters|nmod|elaboration elaboration|nmod|processes processes|nmod|pathway pathway|compound|END_ENTITY	The cationic amino_acid transporters CAT1 and CAT3 mediate NMDA receptor activation-dependent changes in elaboration of neuronal processes via the mammalian_target_of_rapamycin mTOR pathway .
17234578	0	NMDA	59,63	mammalian_target_of_rapamycin	147,176	NMDA	mammalian target of rapamycin	CHEBI:6121	2475	Chemical	Gene	changes|compound|START_ENTITY transporters|dobj|changes transporters|nmod|elaboration elaboration|nmod|processes processes|nmod|pathway pathway|compound|END_ENTITY	The cationic amino_acid transporters CAT1 and CAT3 mediate NMDA receptor activation-dependent changes in elaboration of neuronal processes via the mammalian_target_of_rapamycin mTOR pathway .
22341316	0	NMDA	12,16	mammalian_target_of_rapamycin	49,78	NMDA	mammalian target of rapamycin	CHEBI:6121	2475	Chemical	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Spinal cord NMDA receptor-mediated activation of mammalian_target_of_rapamycin is required for the development and maintenance of bone_cancer-induced pain hypersensitivities in rats .
12144852	0	NMDA	19,23	microtubule-associated_protein_2	90,122	NMDA	microtubule-associated protein 2	CHEBI:6121	25595(Tax:10116)	Chemical	Gene	activation|compound|START_ENTITY activation|nmod|neurons neurons|amod|END_ENTITY	Carnitine prevents NMDA receptor-mediated activation of MAP-kinase and phosphorylation of microtubule-associated_protein_2 in cerebellar neurons in culture .
8207442	0	NMDA	0,4	microtubule-associated_protein_2	31,63	NMDA	microtubule-associated protein 2	CHEBI:6121	4133	Chemical	Gene	increase|nsubj|START_ENTITY increase|dobj|expression expression|amod|END_ENTITY	NMDA and nitric_oxide increase microtubule-associated_protein_2 gene expression in hippocampal granule cells .
20176955	0	NMDA	97,101	neuroligin-1	67,79	NMDA	neuroligin-1	CHEBI:6121	192167(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY END_ENTITY|nmod|receptors	Input-specific synaptic plasticity in the amygdala is regulated by neuroligin-1 via postsynaptic NMDA receptors .
16237959	0	NMDA	45,49	nitric_oxide_synthase	67,88	NMDA	nitric oxide synthase	CHEBI:6121	18125(Tax:10090)	Chemical	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Neuroprotective effect of Chuk-Me-Sun-Dan on NMDA - and AMPA-evoked nitric_oxide_synthase activity in mouse brain .
18331582	0	NMDA	47,51	p250GAP	103,110	NMDA	p250GAP	CHEBI:6121	9743	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Regulation of dendritic spine morphology by an NMDA receptor-associated Rho GTPase-activating protein , p250GAP .
10320040	0	NMDA	0,4	p53	69,72	NMDA	p53	CHEBI:6121	22060(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY mediated|nsubj|receptor mediated|ccomp|immortalized immortalized|nsubj|responses responses|nmod|neurons neurons|acl|differentiated differentiated|nmod|END_ENTITY	NMDA receptor mediated Ca2 + responses in neurons differentiated from p53 - / - immortalized Murine neural stem cells .
10340750	0	NMDA	33,37	p53	0,3	NMDA	p53	CHEBI:6121	301300(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	p53 expression and regulation by NMDA receptors in the developing rat brain .
11006977	0	NMDA	27,31	p53	0,3	NMDA	p53	CHEBI:6121	22060(Tax:10090)	Chemical	Gene	implication|nmod|START_ENTITY implication|compound|END_ENTITY	p53 and Bax implication in NMDA induced-apoptosis in mouse hippocampus .
24718050	0	NMDA	4,8	p53	67,70	NMDA	p53	CHEBI:6121	301300(Tax:10116)	Chemical	Gene	MK-801|compound|START_ENTITY abolishes|nsubj|MK-801 abolishes|dobj|increase increase|nmod|index index|compound|END_ENTITY	The NMDA receptor antagonist MK-801 abolishes the increase in both p53 and Bax/Bcl2 index induced by adult-onset hypothyroidism in rat .
16339032	0	NMDA	14,18	pituitary_adenylate_cyclase_activating_peptide	32,78	NMDA	pituitary adenylate cyclase activating peptide	CHEBI:6121	11516(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|nmod|END_ENTITY	Modulation of NMDA receptors by pituitary_adenylate_cyclase_activating_peptide in CA1 neurons requires G_alpha_q , protein_kinase_C , and activation of Src .
17553983	0	NMDA	46,50	postsynaptic_density-95	65,88	NMDA	postsynaptic density-95	CHEBI:6121	116681(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|nmod|END_ENTITY	Coupling of neuronal nitric_oxide synthase to NMDA receptors via postsynaptic_density-95 depends on estrogen and contributes to the central control of adult female reproduction .
22310309	0	NMDA	31,35	prion_protein	58,71	NMDA	prion protein	D016202	5621	Chemical	Gene	receptors|compound|START_ENTITY receptors|nmod|END_ENTITY	Copper-dependent regulation of NMDA receptors by cellular prion_protein : implications for neurodegenerative_disorders .
7901042	0	NMDA	25,29	prion_protein	54,67	NMDA	prion protein	CHEBI:6121	24686(Tax:10116)	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|nmod|END_ENTITY	Cytoprotective effect of NMDA receptor antagonists on prion_protein -LRB- PrionSc -RRB- - induced toxicity in rat cortical cell cultures .
19013213	0	NMDA	0,4	pyroglutamyl_peptidase_II	27,52	NMDA	pyroglutamyl peptidase II	CHEBI:6121	366894(Tax:10116)	Chemical	Gene	up-regulates|compound|START_ENTITY END_ENTITY|nsubj|up-regulates	NMDA receptor up-regulates pyroglutamyl_peptidase_II activity in the rat hippocampus .
9019541	0	NMDA	43,47	src	101,104	NMDA	src	CHEBI:6121	6714	Chemical	Gene	regulation|nmod|START_ENTITY receptor-channels|nsubj|regulation receptor-channels|nmod|kinases kinases|nmod|family family|compound|END_ENTITY	Subtype-specific regulation of recombinant NMDA receptor-channels by protein tyrosine kinases of the src family .
25069643	0	NMDA_glutamate	0,14	NR1	24,27	NMDA glutamate	NR1	null	2902	Chemical	Gene	START_ENTITY|dobj|expression expression|compound|END_ENTITY	NMDA_glutamate receptor NR1 , NR2A and NR2B expression and NR2B Tyr-1472 phosphorylation in the lens .
20661302	0	NMDA_glutamate	81,95	NR2A	57,61	NMDA glutamate	NR2A	null	14811(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|nummod|END_ENTITY	Long-term potentiation in the CA1 hippocampus induced by NR2A subunit-containing NMDA_glutamate receptors is mediated by Ras-GRF2 / Erk map kinase signaling .
23964123	0	NMDA_glutamate	20,34	NR2B	0,4	NMDA glutamate	NR2B	null	14812(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY subunit|nmod|receptor subunit|nummod|END_ENTITY	NR2B subunit of the NMDA_glutamate receptor regulates appetite in the parabrachial nucleus .
10428462	0	NMN	102,105	YLR328W	39,46	NMN	YLR328W	CHEBI:14648	851039(Tax:4932)	Chemical	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification and characterization of YLR328W , the Saccharomyces_cerevisiae structural gene encoding NMN adenylyltransferase .
7991071	0	NMN	144,147	angiotensin-II	106,120	NMN	angiotensin-II	CHEBI:14648	24179(Tax:10116)	Chemical	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Proliferogenic effect of neurotensin -LRB- NT -RRB- and neuromedin-N -LRB- NMN -RRB- on the rat adrenal cortex : evidence that angiotensin-II mediates the effect of NMN , but not of NT .
23674492	0	NMS-E973	0,8	Hsp90	41,46	NMS-E973	Hsp90	null	3320	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	NMS-E973 , a novel synthetic inhibitor of Hsp90 with activity against multiple models of drug resistance to targeted agents , including intracranial metastases .
12765853	0	NNC-687	100,107	dopamine_D1_receptor	67,87	NNC-687	dopamine D1 receptor	MESH:C077122	1812	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Selective alterations of the first NREM sleep cycle in humans by a dopamine_D1_receptor antagonist -LRB- NNC-687 -RRB- .
24703657	2	NO-1886	308,315	LPL	282,285	NO-1886	C10	MESH:C082137	3226	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Random screening identified a compound designated C10 , showing greater LPL agonist activity than NO-1886 , a known LPL agonist .
10443901	0	NO-1886	107,114	Lipoprotein_lipase	0,18	NO-1886	Lipoprotein lipase	MESH:C082137	24539(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY difference|nmod|effects functions|dep|difference modulates|dobj|functions modulates|nsubj|agent agent|amod|END_ENTITY	Lipoprotein_lipase promoting agent , NO-1886 , modulates adrenal functions : species difference in effects of NO-1886 on steroidogenesis .
10443901	0	NO-1886	36,43	Lipoprotein_lipase	0,18	NO-1886	Lipoprotein lipase	MESH:C082137	24539(Tax:10116)	Chemical	Gene	agent|appos|START_ENTITY agent|amod|END_ENTITY	Lipoprotein_lipase promoting agent , NO-1886 , modulates adrenal functions : species difference in effects of NO-1886 on steroidogenesis .
19229602	0	NO-1886	0,7	NPC1	46,50	NO-1886	NPC1	MESH:C082137	4864	Chemical	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	NO-1886 up-regulates Niemann-Pick_C1 protein -LRB- NPC1 -RRB- expression through liver X receptor alpha signaling pathway in THP-1 macrophage-derived foam cells .
19434486	1	NO-1886	122,129	NPC1	168,172	NO-1886	NPC1	MESH:C082137	4864	Chemical	Gene	START_ENTITY|dobj|expression expression|amod|Niemann-Pick_C1_protein Niemann-Pick_C1_protein|dep|END_ENTITY	Editorial to : `` NO-1886 up-regulates Niemann-Pick_C1_protein -LRB- NPC1 -RRB- expression through liver X receptor alpha signaling pathway in THP-1 macrophage-derived foam cells '' by Xin Ma et al. .
19229602	0	NO-1886	0,7	Niemann-Pick_C1	21,36	NO-1886	Niemann-Pick C1	MESH:C082137	4864	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	NO-1886 up-regulates Niemann-Pick_C1 protein -LRB- NPC1 -RRB- expression through liver X receptor alpha signaling pathway in THP-1 macrophage-derived foam cells .
19434486	1	NO-1886	122,129	Niemann-Pick_C1_protein	143,166	NO-1886	Niemann-Pick C1 protein	MESH:C082137	4864	Chemical	Gene	START_ENTITY|dobj|expression expression|amod|END_ENTITY	Editorial to : `` NO-1886 up-regulates Niemann-Pick_C1_protein -LRB- NPC1 -RRB- expression through liver X receptor alpha signaling pathway in THP-1 macrophage-derived foam cells '' by Xin Ma et al. .
10719613	0	NO-1886	11,18	lipoprotein_lipase	22,40	NO-1886	lipoprotein lipase	MESH:C082137	100340171(Tax:9986)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of NO-1886 , a lipoprotein_lipase promoting agent , on homozygous and heterozygous Watanabe_heritable_hyperlipidaemic rabbits .
15710887	0	NO-1886	75,82	lipoprotein_lipase	95,113	NO-1886	lipoprotein lipase	MESH:C082137	16956(Tax:10090)	Chemical	Gene	formation|nmod|START_ENTITY suppression|nmod|formation increasing|nsubj|suppression increasing|dobj|activity activity|amod|END_ENTITY	Concurrent suppression of hyperlipidemia and intestinal_polyp formation by NO-1886 , increasing lipoprotein_lipase activity in Min mice .
16311090	0	NO-1886	0,7	lipoprotein_lipase	23,41	NO-1886	lipoprotein lipase	MESH:C082137	24539(Tax:10116)	Chemical	Gene	START_ENTITY|appos|activator activator|amod|END_ENTITY	NO-1886 -LRB- ibrolipim -RRB- , a lipoprotein_lipase activator , increases the expression of uncoupling protein 3 in skeletal muscle and suppresses fat accumulation in high-fat diet-induced obesity in rats .
8326009	0	NO-1886	19,26	lipoprotein_lipase	37,55	NO-1886	lipoprotein lipase	MESH:C082137	24539(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|activity activity|amod|END_ENTITY	The novel compound NO-1886 increases lipoprotein_lipase activity with resulting elevation of high density lipoprotein cholesterol , and long-term administration inhibits atherogenesis in the coronary arteries of rats with experimental atherosclerosis .
9353574	0	NO-1886	19,26	lipoprotein_lipase	37,55	NO-1886	lipoprotein lipase	MESH:C082137	24539(Tax:10116)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	The novel compound NO-1886 activates lipoprotein_lipase in primary cultured adipose and skeletal muscle cells .
9440486	0	NO-1886	103,110	lipoprotein_lipase	114,132	NO-1886	lipoprotein lipase	MESH:C082137	24539(Tax:10116)	Chemical	Gene	START_ENTITY|appos|activator activator|amod|END_ENTITY	Suppression of carcass weight_loss in cachexia in rats bearing Leydig_cell_tumor by the novel compound NO-1886 , a lipoprotein_lipase activator .
17329906	0	NO-aspirin	64,74	Cytochrome_P450	0,15	NO-aspirin	Cytochrome P450	MESH:C488176	4051	Chemical	Gene	responsible|nmod|START_ENTITY responsible|nsubj|END_ENTITY	Cytochrome_P450 is responsible for nitric_oxide generation from NO-aspirin and other organic nitrates .
19589334	0	NO-cGMP	26,33	ERK	7,10	NO-cGMP	ERK	null	26413(Tax:10090)	Chemical	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Spinal ERK activation via NO-cGMP pathway contributes to nociceptive behavior induced by morphine-3-glucuronide .
21412525	0	NO2	96,99	NO3	71,74	NO2	NO3	CHEBI:29785	4681	Chemical	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	Damage of aromatic amino_acids by the atmospheric free radical oxidant NO3 in the presence of NO2 , N2O4 , O3 and O2 .
2782877	0	NO2	53,56	NO3	59,62	NO2	NO3	CHEBI:29785	4681	Chemical	Gene	-|compound|START_ENTITY -|appos|END_ENTITY	Heterotrophic nitrification by Alcaligenes faecalis : NO2 - , NO3 - , N2O , and NO production in exponentially growing cultures .
543701	0	NO2	49,52	NO3	40,43	NO2	NO3	CHEBI:29785	4681	Chemical	Gene	Distribution|dep|START_ENTITY Distribution|nmod|END_ENTITY	Distribution and metabolism of ingested NO3 - and NO2 - in germfree and conventional-flora rats .
25219376	0	NOC-18	46,52	PKG	115,118	NOC-18	PKG	MESH:C093285	5592	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|role role|nmod|END_ENTITY	Neuroprotective effects of nitric_oxide donor NOC-18 against brain_ischemia-induced mitochondrial damages : role of PKG and PKC .
24677341	0	NOC-5	19,24	XIAP	35,39	NOC-5	XIAP	MESH:C114535	331	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|level level|compound|END_ENTITY	Nitric_oxide donor NOC-5 increases XIAP and Aven level in Jurkat cells .
19427360	0	NOC-9	0,5	soluble_guanylate_cyclase	126,151	NOC-9	soluble guanylate cyclase	MESH:C099612	25206(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|activating activating|dobj|END_ENTITY	NOC-9 , a selective nitric_oxide donor , induces flight reactions in the dorsolateral periaqueductal gray of rats by activating soluble_guanylate_cyclase .
6408155	7	NOM	988,991	TRH	1070,1073	NOM	TRH	null	7200	Chemical	Gene	induced|nsubj|START_ENTITY induced|nmod|END_ENTITY	The mechanism by which NOM induced dopaminergic activation leads to the suppression of TSH release after TRH has not yet been elucidated .
24277076	0	NOX-A12	15,22	CXCL12	32,38	NOX-A12	CXCL12	null	6387	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	The Spiegelmer NOX-A12 , a novel CXCL12 inhibitor , interferes with chronic_lymphocytic_leukemia cell motility and causes chemosensitization .
15994217	0	NOX-B11	24,31	ghrelin	95,102	NOX-B11	ghrelin	MESH:C510682	59301(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|effects effects|nmod|END_ENTITY	Anti-ghrelin Spiegelmer NOX-B11 inhibits neurostimulatory and orexigenic effects of peripheral ghrelin in rats .
25829494	6	NOXA	992,996	CDK5	1000,1004	NOXA	CDK5	CHEBI:50397	1020	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|compound|END_ENTITY	The increased abundance of NOXA by CDK5 inhibition was not a result of changes in NOXA protein turnover .
21543745	0	NP603	0,5	FGFR1	39,44	NP603	FGFR1	MESH:C561467	79114(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|kinase kinase|compound|END_ENTITY	NP603 , a novel and potent inhibitor of FGFR1 tyrosine kinase , inhibits hepatic stellate cell proliferation and ameliorates hepatic_fibrosis in rats .
21622134	0	NPB001-05	0,9	Bcr-Abl	19,26	NPB001-05	Bcr-Abl	MESH:C561621	25	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|kinase kinase|amod|END_ENTITY	NPB001-05 inhibits Bcr-Abl kinase leading to apoptosis of imatinib-resistant cells .
1965113	0	NPC_567	54,61	bradykinin	31,41	NPC 567	bradykinin	MESH:C053010	3827	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	A study of the efficacy of the bradykinin antagonist , NPC_567 , in rhinovirus_infections in human volunteers .
18424742	0	NPI-0052	124,132	DR5	57,60	NPI-0052	DR5	MESH:C475865	8795	Chemical	Gene	transcription|nmod|START_ENTITY transcription|compound|END_ENTITY	Inhibition of Yin_Yang_1-dependent repressor activity of DR5 transcription and expression by the novel proteasome inhibitor NPI-0052 contributes to its TRAIL-enhanced apoptosis in cancer cells .
10579464	0	NRA0160	45,52	dopamine_D4_receptor	12,32	NRA0160	dopamine D4 receptor	MESH:C121249	25432(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	A selective dopamine_D4_receptor antagonist , NRA0160 : a preclinical neuropharmacological profile .
10619364	0	NRA0160	52,59	dopamine_D4_receptor	21,41	NRA0160	dopamine D4 receptor	MESH:C121249	25432(Tax:10116)	Chemical	Gene	blockers|appos|START_ENTITY blockers|amod|END_ENTITY	Effects of selective dopamine_D4_receptor blockers , NRA0160 and L-745 ,870 , on A9 and A10 dopamine neurons in rats .
24679585	0	NS-018	0,6	JAK2	20,24	NS-018	JAK2	null	3717	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	NS-018 , a selective JAK2 inhibitor , preferentially inhibits CFU-GM colony formation by bone marrow mononuclear cells from high-risk myelodysplastic_syndrome patients .
10987308	0	NS-398	110,116	COX-2	93,98	NS-398	COX-2	MESH:C080955	5743	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Expression of cyclooxygenase_2 -LRB- COX-2 -RRB- in human glioma and in vitro inhibition by a specific COX-2 inhibitor , NS-398 .
11327079	4	NS-398	696,702	COX-2	716,721	NS-398	COX-1	MESH:C080955	5742	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	NS-398 , a selective COX-2 inhibitor , inhibited PGE2 production by FBS-stimulated cells as completely as indomethacin , a non-selective COX-1 / COX-2 inhibitor .
11350912	0	NS-398	134,140	COX-2	117,122	NS-398	COX-2	MESH:C080955	5743	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Expression of cyclooxygenase-2 -LRB- COX-2 -RRB- in hepatocellular_carcinoma and growth inhibition of hepatoma cell lines by a COX-2 inhibitor , NS-398 .
11350912	0	NS-398	134,140	COX-2	32,37	NS-398	COX-2	MESH:C080955	5743	Chemical	Gene	inhibitor|appos|START_ENTITY lines|nmod|inhibitor inhibition|nmod|lines Expression|nmod|inhibition Expression|appos|END_ENTITY	Expression of cyclooxygenase-2 -LRB- COX-2 -RRB- in hepatocellular_carcinoma and growth inhibition of hepatoma cell lines by a COX-2 inhibitor , NS-398 .
11876163	0	NS-398	26,32	COX-2	0,5	NS-398	COX-2	MESH:C080955	5743	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	COX-2 specific inhibitor , NS-398 , increases macrophage_migration_inhibitory_factor expression and induces neuroendocrine differentiation in C4-2b prostate_cancer cells .
12088417	0	NS-398	20,26	COX-2	82,87	NS-398	COX-2	MESH:C080955	17709(Tax:10090)	Chemical	Gene	causes|nsubj|START_ENTITY causes|dobj|disruptions disruptions|nmod|inhibition inhibition|compound|END_ENTITY	The COX-2 inhibitor NS-398 causes T-cell developmental disruptions independent of COX-2 enzyme inhibition .
12107271	4	NS-398	562,568	COX-2	545,550	NS-398	COX-2	MESH:C080955	5743	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Pretreatment of HMEC-1 with a selective COX-2 inhibitor , NS-398 , abolished VEGF-induced PGE -LRB- 2 -RRB- synthesis , suggesting specific up-regulation of COX-2 activity by VEGF in HMEC-1 .
12124326	8	NS-398	969,975	COX-2	1043,1048	NS-398	COX-2	MESH:C080955	17709(Tax:10090)	Chemical	Gene	coincubated|nmod|START_ENTITY coincubated|xcomp|indicating indicating|ccomp|induced induced|dobj|expression expression|nmod|END_ENTITY	Prostaglandin -LRB- PG -RRB- E2 synthesis was also increased in PDT-treated cells , and PGE2 levels were attenuated in cells coincubated with NS-398 , indicating that PDT induced the expression of biologically active COX-2 .
12632065	0	NS-398	79,85	COX-2	99,104	NS-398	COX-2	MESH:C080955	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Inhibited proliferation of cyclooxygenase-2 expressing human hepatoma cells by NS-398 , a selective COX-2 inhibitor .
15130753	0	NS-398	27,33	COX-2	10,15	NS-398	COX-2	MESH:C080955	5743	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Selective COX-2 inhibitor , NS-398 , inhibits the replicative senescence of cultured dermal fibroblasts .
15151617	0	NS-398	121,127	COX-2	104,109	NS-398	COX-2	MESH:C080955	5743	Chemical	Gene	inhibition|xcomp|START_ENTITY inhibition|nmod|inhibitor inhibitor|compound|END_ENTITY	Expression of cyclooxygenase-2 -LRB- COX-2 -RRB- in human esophageal_cancer and in vitro inhibition by a specific COX-2 inhibitor , NS-398 .
15151617	0	NS-398	121,127	COX-2	32,37	NS-398	COX-2	MESH:C080955	5743	Chemical	Gene	inhibition|xcomp|START_ENTITY inhibition|nsubj|Expression Expression|nmod|END_ENTITY	Expression of cyclooxygenase-2 -LRB- COX-2 -RRB- in human esophageal_cancer and in vitro inhibition by a specific COX-2 inhibitor , NS-398 .
15621834	1	NS-398	112,118	COX-2	163,168	NS-398	COX-2	MESH:C080955	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|cyclooxygenase_2 cyclooxygenase_2|appos|END_ENTITY	NS-398 , a selective inhibitor of cyclooxygenase_2 -LRB- COX-2 -RRB- , has been reported to inhibit growth and induce apoptosis in several cancer cell lines that overexpress COX-2 .
17451196	0	NS-398	27,33	COX-2	10,15	NS-398	COX-2	MESH:C080955	5743	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Selective COX-2 inhibitor , NS-398 , suppresses cellular proliferation in human hepatocellular_carcinoma cell lines via cell cycle arrest .
18065658	10	NS-398	1446,1452	COX-2	1483,1488	NS-398	COX-2	MESH:C080955	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|appos|END_ENTITY	An anti-IL-1beta antibody partially -LRB- > 50 % -RRB- inhibited the BALF-induced HGF and PGE -LRB- 2 -RRB- secretion , whereas NS-398 , a specific cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitor , completely inhibited it .
18809379	0	NS-398	0,6	COX-2	20,25	NS-398	COX-2	MESH:C080955	4513	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	NS-398 , a selective COX-2 inhibitor , inhibits proliferation of IL-1beta-stimulated vascular smooth muscle cells by induction of HO-1 .
19056168	1	NS-398	427,433	COX-2	226,231	NS-398	COX-2	MESH:C080955	5743	Chemical	Gene	inhibitor|appos|START_ENTITY combination|nmod|inhibitor effects|nmod|combination remains|nsubj|effects remains|advcl|leads leads|nsubj|inhibition inhibition|nmod|cyclooxygenase-2 cyclooxygenase-2|appos|END_ENTITY	Although inhibition of cyclooxygenase-2 -LRB- COX-2 -RRB- or activation of peroxisome_proliferators-activated_receptor_gamma -LRB- PPAR-gamma -RRB- leads to growth inhibition in malignancies , the synergistic anti-tumor effects of combination of COX-2 inhibitor -LRB- NS-398 -RRB- and PPAR-gamma agonist -LRB- rosiglitazone -RRB- on the human pancreatic_cancer cells remains unknown .
24500985	8	NS-398	1478,1484	COX-2	1502,1507	NS-398	Smad7	MESH:C080955	81516(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	In addition , the expression of Smad3 and Smad7 was significantly reduced not only by staurosporine , an inhibitor of threonine/serine protein kinases as well as smad , but also by NS-398 , an inhibitor of COX-2 .
25453777	0	NS-398	97,103	COX-2	80,85	NS-398	COX-2	MESH:C080955	29527(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Co-administration of subtherapeutic diazepam enhances neuroprotective effect of COX-2 inhibitor , NS-398 , after lithium pilocarpine-induced status_epilepticus .
8140262	0	NS-398	0,6	COX-2	103,108	NS-398	COX-2	MESH:C080955	26198(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|prostaglandin_G prostaglandin_G|xcomp|activity activity|appos|END_ENTITY	NS-398 , a new anti-inflammatory agent , selectively inhibits prostaglandin_G / H synthase/cyclooxygenase -LRB- COX-2 -RRB- activity in vitro .
9309800	8	NS-398	1224,1230	COX-2	1241,1246	NS-398	COX-1	MESH:C080955	26195(Tax:10116)	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|dobj|END_ENTITY	NS-398 inhibited COX-2 with an IC50 of 0.32 microM , but never affected COX-1 activity , even at 100 microM .
14760389	0	NS-398	43,49	Cyclooxygenase-2	0,16	NS-398	Cyclooxygenase-2	MESH:C080955	19225(Tax:10090)	Chemical	Gene	suppresses|amod|START_ENTITY proliferation|amod|suppresses inhibition|nmod|proliferation inhibition|amod|END_ENTITY	Cyclooxygenase-2 selective inhibition with NS-398 suppresses proliferation and invasiveness and delays liver metastasis in colorectal_cancer .
18809379	0	NS-398	0,6	HO-1	128,132	NS-398	HO-1	MESH:C080955	3162	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|induction induction|nmod|END_ENTITY	NS-398 , a selective COX-2 inhibitor , inhibits proliferation of IL-1beta-stimulated vascular smooth muscle cells by induction of HO-1 .
22553634	0	NS-398	27,33	IL-10	37,42	NS-398	IL-10	MESH:C080955	25325(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effects of COX-2 inhibitor NS-398 on IL-10 expression in rat fungal_keratitis .
10477832	0	NS-398	19,25	PGHS-2	0,6	NS-398	PGHS-2	MESH:C080955	5743	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	PGHS-2 inhibitors , NS-398 and DuP-697 , attenuate the inhibition of PGHS-1 by aspirin and indomethacin without altering its activity .
21679035	0	NS-398	87,93	beta-catenin	163,175	NS-398	beta-catenin	MESH:C080955	12387(Tax:10090)	Chemical	Gene	treated|nmod|START_ENTITY mice|acl|treated progression|nmod|mice associated|nsubjpass|progression associated|nmod|down-regulation down-regulation|nmod|localisation localisation|amod|END_ENTITY	Reduced tumour progression and angiogenesis in 1,2-dimethylhydrazine mice treated with NS-398 is associated with down-regulation of cyclooxygenase-2 and decreased beta-catenin nuclear localisation .
10440208	0	NS-398	41,47	cyclo-oxygenase-2	12,29	NS-398	cyclo-oxygenase-2	MESH:C080955	29527(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	A selective cyclo-oxygenase-2 inhibitor , NS-398 , may improve portal hypertension without inducing gastric_mucosal_injury .
10363578	0	NS-398	80,86	cyclooxygenase-2	101,117	NS-398	cyclooxygenase-2	MESH:C080955	29527(Tax:10116)	Chemical	Gene	methane_sulfonamide|appos|START_ENTITY methane_sulfonamide|appos|inhibitor inhibitor|amod|END_ENTITY	Chemopreventive effect of N - -LRB- 2-cyclohexyloxy-4-nitrophenyl -RRB- methane_sulfonamide -LRB- NS-398 -RRB- , a selective cyclooxygenase-2 inhibitor , in rat colon_carcinogenesis induced by azoxymethane .
10541284	0	NS-398	0,6	cyclooxygenase-2	32,48	NS-398	cyclooxygenase-2	MESH:C080955	19225(Tax:10090)	Chemical	Gene	upregulates|compound|START_ENTITY constitutive|nsubj|upregulates constitutive|dobj|expression expression|amod|END_ENTITY	NS-398 upregulates constitutive cyclooxygenase-2 expression in the M-1 cortical_collecting_duct cell line .
11179483	0	NS-398	107,113	cyclooxygenase-2	127,143	NS-398	cyclooxygenase-2	MESH:C080955	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Dose-dependent modulation of apoptosis and cyclooxygenase-2 expression in human 1547 osteosarcoma cells by NS-398 , a selective cyclooxygenase-2 inhibitor .
11350912	0	NS-398	134,140	cyclooxygenase-2	14,30	NS-398	cyclooxygenase-2	MESH:C080955	5743	Chemical	Gene	inhibitor|appos|START_ENTITY lines|nmod|inhibitor inhibition|nmod|lines Expression|nmod|inhibition Expression|nmod|END_ENTITY	Expression of cyclooxygenase-2 -LRB- COX-2 -RRB- in hepatocellular_carcinoma and growth inhibition of hepatoma cell lines by a COX-2 inhibitor , NS-398 .
11595687	0	NS-398	40,46	cyclooxygenase-2	12,28	NS-398	cyclooxygenase-2	MESH:C080955	5743	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	A selective cyclooxygenase-2 inhibitor , NS-398 , enhances the effect of radiation in vitro and in vivo preferentially on the cells that express cyclooxygenase-2 .
11595687	0	NS-398	40,46	cyclooxygenase-2	143,159	NS-398	cyclooxygenase-2	MESH:C080955	5743	Chemical	Gene	inhibitor|appos|START_ENTITY enhances|nsubj|inhibitor enhances|nmod|cells cells|acl:relcl|express express|xcomp|END_ENTITY	A selective cyclooxygenase-2 inhibitor , NS-398 , enhances the effect of radiation in vitro and in vivo preferentially on the cells that express cyclooxygenase-2 .
12401438	0	NS-398	0,6	cyclooxygenase-2	8,24	NS-398	cyclooxygenase-2	MESH:C080955	19225(Tax:10090)	Chemical	Gene	START_ENTITY|dep|inhibition inhibition|amod|END_ENTITY	NS-398 : cyclooxygenase-2 independent inhibition of leukocyte priming for lipid body formation and enhanced leukotriene generation .
12433932	0	NS-398	0,6	cyclooxygenase-2	100,116	NS-398	cyclooxygenase-2	MESH:C080955	19225(Tax:10090)	Chemical	Gene	suppress|nsubj|START_ENTITY suppress|nmod|mechanisms mechanisms|amod|independent independent|advcl|END_ENTITY	NS-398 and piroxicam suppress UVB-induced activator_protein_1 activity by mechanisms independent of cyclooxygenase-2 .
12498919	0	NS-398	0,6	cyclooxygenase-2	20,36	NS-398	cyclooxygenase-2	MESH:C080955	29527(Tax:10116)	Chemical	Gene	START_ENTITY|appos|blocker blocker|amod|END_ENTITY	NS-398 , a selective cyclooxygenase-2 blocker , acutely inhibits receptor-mediated contractions of rat aorta : role of endothelium .
12632065	0	NS-398	79,85	cyclooxygenase-2	27,43	NS-398	cyclooxygenase-2	MESH:C080955	5743	Chemical	Gene	expressing|nmod|START_ENTITY expressing|xcomp|END_ENTITY	Inhibited proliferation of cyclooxygenase-2 expressing human hepatoma cells by NS-398 , a selective COX-2 inhibitor .
14981912	0	NS-398	40,46	cyclooxygenase-2	12,28	NS-398	cyclooxygenase-2	MESH:C080955	5743	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	A selective cyclooxygenase-2 inhibitor , NS-398 , inhibits cell growth by cell cycle arrest in a human malignant_fibrous_histiocytoma cell line .
15142421	0	NS-398	34,40	cyclooxygenase-2	14,30	NS-398	cyclooxygenase-2	MESH:C080955	19225(Tax:10090)	Chemical	Gene	following|compound|START_ENTITY END_ENTITY|nmod|following	Inhibition of cyclooxygenase-2 by NS-398 following hemorrhage and subsequent sepsis : no beneficial effects in either gender .
15151617	0	NS-398	121,127	cyclooxygenase-2	14,30	NS-398	cyclooxygenase-2	MESH:C080955	5743	Chemical	Gene	inhibition|xcomp|START_ENTITY inhibition|nsubj|Expression Expression|nmod|COX-2 COX-2|amod|END_ENTITY	Expression of cyclooxygenase-2 -LRB- COX-2 -RRB- in human esophageal_cancer and in vitro inhibition by a specific COX-2 inhibitor , NS-398 .
15306209	0	NS-398	22,28	cyclooxygenase-2	42,58	NS-398	cyclooxygenase-2	MESH:C080955	100135607(Tax:10141)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Antitussive effect of NS-398 , a selective cyclooxygenase-2 inhibitor , in guinea_pigs .
16098373	0	NS-398	0,6	cyclooxygenase-2	20,36	NS-398	cyclooxygenase-2	MESH:C080955	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	NS-398 , a selective cyclooxygenase-2 inhibitor , reduces experimental bladder_carcinoma outgrowth by inhibiting tumor cell proliferation .
18763637	0	NS-398	11,17	cyclooxygenase-2	21,37	NS-398	cyclooxygenase-2	MESH:C080955	5743	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effect of NS-398 on cyclooxygenase-2 expression and proliferation of HepG2 cells -RSB- .
19160097	0	NS-398	0,6	cyclooxygenase-2	115,131	NS-398	cyclooxygenase-2	MESH:C080955	5743	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|inhibition inhibition|nmod|regulation regulation|nmod|END_ENTITY	NS-398 induces apoptosis in human esophageal_cancer cells through inhibition of NF-kappaB downstream regulation of cyclooxygenase-2 .
20958135	0	NS-398	0,6	cyclooxygenase-2	20,36	NS-398	cyclooxygenase-2	MESH:C080955	5743	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	NS-398 -LRB- a selective cyclooxygenase-2 inhibitor -RRB- decreases agonist-induced contraction of the human ureter via calcium channel inhibition .
21679035	0	NS-398	87,93	cyclooxygenase-2	132,148	NS-398	cyclooxygenase-2	MESH:C080955	19225(Tax:10090)	Chemical	Gene	treated|nmod|START_ENTITY mice|acl|treated progression|nmod|mice associated|nsubjpass|progression associated|nmod|down-regulation down-regulation|nmod|localisation localisation|amod|END_ENTITY	Reduced tumour progression and angiogenesis in 1,2-dimethylhydrazine mice treated with NS-398 is associated with down-regulation of cyclooxygenase-2 and decreased beta-catenin nuclear localisation .
21843643	0	NS-398	17,23	cyclooxygenase-2	33,49	NS-398	cyclooxygenase-2	MESH:C080955	19225(Tax:10090)	Chemical	Gene	structure|nmod|START_ENTITY bound|nsubj|structure bound|nmod|END_ENTITY	The structure of NS-398 bound to cyclooxygenase-2 .
22545970	0	NS-398	122,128	cyclooxygenase-2	94,110	NS-398	cyclooxygenase-2	MESH:C080955	29527(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Contribution of vasoactive eicosanoids and nitric_oxide production to the effect of selective cyclooxygenase-2 inhibitor , NS-398 , on endotoxin-induced hypotension in rats .
23456767	0	NS-398	10,16	cyclooxygenase-2	20,36	NS-398	cyclooxygenase-2	MESH:C080955	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effect of NS-398 , a cyclooxygenase-2 selective inhibitor , on the cytotoxicity of cytotoxic T lymphocytes to ovarian_carcinoma cells .
26281984	0	NS-398	30,36	cyclooxygenase-2	40,56	NS-398	cyclooxygenase-2	MESH:C080955	5743	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|inhibitor inhibitor|amod|selective selective|amod|END_ENTITY	Retraction Note to : Effect of NS-398 , a cyclooxygenase-2 selective inhibitor , on the cytotoxicity of cytotoxic T lymphocytes to ovarian_carcinoma cells .
26281984	0	NS-398	30,36	cyclooxygenase-2	40,56	NS-398	cyclooxygenase-2	MESH:C080955	5743	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|inhibitor inhibitor|amod|selective selective|amod|END_ENTITY	Retraction Note to : Effect of NS-398 , a cyclooxygenase-2 selective inhibitor , on the cytotoxicity of cytotoxic T lymphocytes to ovarian_carcinoma cells .
9263538	0	NS-398	21,27	cyclooxygenase-2	41,57	NS-398	cyclooxygenase-2	MESH:C080955	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Apoptosis induced by NS-398 , a selective cyclooxygenase-2 inhibitor , in human colorectal_cancer cell lines .
9439679	0	NS-398	21,27	cyclooxygenase-2	41,57	NS-398	cyclooxygenase-2	MESH:C080955	29527(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Inhibitory effect of NS-398 , a selective cyclooxygenase-2 inhibitor , on azoxymethane-induced aberrant_crypt_foci in colon_carcinogenesis of F344 rats .
12115513	0	NS-398	0,6	cyclooxygenase_2	20,36	NS-398	cyclooxygenase 2	MESH:C080955	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	NS-398 , a selective cyclooxygenase_2 inhibitor , inhibited cell growth and induced cell cycle arrest in human hepatocellular_carcinoma cell lines .
12372403	0	NS-398	144,150	cyclooxygenase_2	116,132	NS-398	cyclooxygenase 2	MESH:C080955	5743	Chemical	Gene	actin|dep|START_ENTITY actin|nmod|inhibitor inhibitor|amod|END_ENTITY	Inhibition of the expression of alpha-smooth muscle actin in human hepatic stellate cell line , LI90 , by a selective cyclooxygenase_2 inhibitor , NS-398 .
17675106	0	NS-398	44,50	heme_oxygenase-1	14,30	NS-398	heme oxygenase-1	MESH:C080955	3162	Chemical	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Akt-dependent heme_oxygenase-1 induction by NS-398 in C6 glial cells : a potential role for CO in prevention of oxidative damage from hypoxia .
8958831	0	NS-398	60,66	prostaglandin_H_synthase-2	22,48	NS-398	prostaglandin H synthase-2	MESH:C080955	100135607(Tax:10141)	Chemical	Gene	Effect|appos|START_ENTITY Effect|nmod|inhibitor inhibitor|amod|END_ENTITY	Effect of a selective prostaglandin_H_synthase-2 inhibitor -LRB- NS-398 -RRB- on prostaglandin production by the guinea-pig uterus .
9007522	0	NS-49	0,5	alpha_1A-adrenoceptor	10,31	NS-49	alpha 1A-adrenoceptor	MESH:C092989	403866(Tax:9615)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	NS-49 , an alpha_1A-adrenoceptor agonist , selectively increases intraurethral pressure in dogs .
15633216	0	NS398	25,30	BCL-2	95,100	NS398	BCL-2	MESH:C080955	596	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|apoptosis apoptosis|nmod|HepG2 HepG2|nmod|END_ENTITY	Specific COX-2 inhibitor NS398 induces apoptosis in human liver_cancer cell line HepG2 through BCL-2 .
14630280	10	NS398	1307,1312	COX-2	1361,1366	NS398	COX-2	MESH:C080955	5743	Chemical	Gene	effect|nmod|START_ENTITY CONCLUSIONS|dep|effect due|nsubj|CONCLUSIONS due|nmod|inhibition inhibition|nmod|upregulation upregulation|compound|END_ENTITY	CONCLUSIONS : The radiosensitizing effect of NS398 could be due to inhibition of radiation-induced COX-2 upregulation by this drug .
15767780	0	NS398	17,22	COX-2	0,5	NS398	COX-2	MESH:C080955	4513	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	COX-2 inhibitor , NS398 , enhances Fas-mediated apoptosis via modulation of the PTEN-Akt pathway in human gastric_carcinoma cell lines .
18718465	5	NS398	1225,1230	COX-2	1316,1321	NS398	COX-2	MESH:C080955	4513	Chemical	Gene	inhibitor|appos|START_ENTITY attenuated|nsubj|inhibitor attenuated|advcl|implying implying|dobj|role role|nmod|activity activity|compound|END_ENTITY	However , the COX-2-selective inhibitor , NS398 , also attenuated VEGF-induced proliferation , implying a distinct role for endogenous COX-2 activity in regulating EC behaviour .
19183882	0	NS398	0,5	COX-2	117,122	NS398	COX-2	MESH:C080955	4513	Chemical	Gene	protects|nsubj|START_ENTITY protects|advcl|enhancing enhancing|dobj|independent independent|nmod|inhibition inhibition|compound|END_ENTITY	NS398 protects cells from sodium_nitroprusside-mediated cytotoxicity through enhancing HO-1 induction independent of COX-2 inhibition .
19956533	0	NS398	24,29	COX-2	43,48	NS398	COX-2	MESH:C080955	4513	Chemical	Gene	apoptosis|nmod|START_ENTITY Pattern|nmod|apoptosis Pattern|appos|inhibitor inhibitor|compound|END_ENTITY	Pattern of apoptosis by NS398 , a selective COX-2 inhibitor , in hepatocellular_carcinoma cell lines .
20087348	0	NS398	80,85	COX2	96,100	NS398	COX2	MESH:C080955	4513	Chemical	Gene	inhibitor|nummod|START_ENTITY inhibitor|compound|END_ENTITY	Reversal of gene expression changes in the colorectal normal-adenoma pathway by NS398 selective COX2 inhibitor .
18481419	0	NS398	37,42	RECK	57,61	NS398	RECK	MESH:C080955	8434	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	-LSB- Nonsteroidal anti-inflammatory drug NS398 regulates the RECK gene expression in the prostate_carcinoma strain DU145 -RSB- .
9766645	0	NS398	0,5	bcl-2	84,89	NS398	bcl-2	MESH:C080955	596	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	NS398 , a selective cyclooxygenase-2 inhibitor , induces apoptosis and down-regulates bcl-2 expression in LNCaP cells .
11309352	0	NS398	75,80	cyclooxygenase-2	48,64	NS398	cyclooxygenase-2	MESH:C080955	5743	Chemical	Gene	START_ENTITY|nsubj|Induction Induction|nmod|apoptosis apoptosis|nmod|cells cells|nmod|inhibitor inhibitor|amod|END_ENTITY	Induction of apoptosis in colon_cancer cells by cyclooxygenase-2 inhibitor NS398 through a cytochrome_c-dependent pathway .
12659684	0	NS398	140,145	cyclooxygenase-2	112,128	NS398	cyclooxygenase-2	MESH:C080955	5743	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Reduced 15S-lipoxygenase-2 expression in esophageal_cancer specimens and cells and upregulation in vitro by the cyclooxygenase-2 inhibitor , NS398 .
15354416	0	NS398	40,45	cyclooxygenase-2	12,28	NS398	cyclooxygenase-2	MESH:C080955	5743	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	A selective cyclooxygenase-2 inhibitor , NS398 , inhibits cell growth and induces cell cycle arrest in the G2/M phase in human esophageal_squamous_cell_carcinoma cells .
15382039	0	NS398	0,5	cyclooxygenase-2	105,121	NS398	cyclooxygenase-2	MESH:C080955	5743	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|_ _|dep|effects effects|nmod|mechanisms mechanisms|amod|END_ENTITY	NS398 reduces hypoxia-inducible_factor _ -LRB- HIF -RRB- -1 alpha and HIF-1 activity : multiple-level effects involving cyclooxygenase-2 dependent and independent mechanisms .
9766645	0	NS398	0,5	cyclooxygenase-2	19,35	NS398	cyclooxygenase-2	MESH:C080955	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	NS398 , a selective cyclooxygenase-2 inhibitor , induces apoptosis and down-regulates bcl-2 expression in LNCaP cells .
23748055	0	NS9775	89,95	nicotinic_acetylcholine_receptor	14,46	NS9775	nicotinic acetylcholine receptor	null	11441(Tax:10090)	Chemical	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	A combined a7 nicotinic_acetylcholine_receptor agonist and monoamine reuptake inhibitor , NS9775 , represents a novel profile with potential benefits in emotional and cognitive_disturbances .
19233143	0	NSC-87877	0,9	PTPs	32,36	NSC-87877	PTPs	MESH:C512715	5805	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	NSC-87877 , inhibitor of SHP-1 / 2 PTPs , inhibits dual-specificity phosphatase 26 -LRB- DUSP26 -RRB- .
20149240	0	NSC114792	0,9	JAK3	124,128	NSC114792	JAK3	MESH:C549326	3718	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	NSC114792 , a novel small molecule identified through structure-based computational database screening , selectively inhibits JAK3 .
20432054	0	NSC126188	0,9	RhoB	80,84	NSC126188	RhoB	MESH:C558305	388	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|apoptosis apoptosis|nmod|upregulation upregulation|nmod|END_ENTITY	NSC126188 , a piperazine_alkyl derivative , induces apoptosis via upregulation of RhoB in HeLa cells .
15128949	4	NSC23766	501,509	Rac1	611,615	NSC23766	Rac1	MESH:C487513	5879	Chemical	Gene	identified|nsubjpass|START_ENTITY identified|nmod|screening screening|nmod|compounds compounds|acl:relcl|fit fit|nmod|groove groove|nmod|END_ENTITY	The chemical compound NSC23766 was identified by a structure-based virtual screening of compounds that fit into a surface groove of Rac1 known to be critical for GEF specification .
18183417	0	NSC23766	20,28	Rac1	4,8	NSC23766	Rac1	MESH:C487513	5879	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	The Rac1 inhibitor , NSC23766 , depolarizes adhesive secretion , endomembrane cycling , and tip growth in the fucoid alga , Silvetia compressa .
18183417	5	NSC23766	913,921	Rac1	740,744	NSC23766	Rac1	MESH:C487513	5879	Chemical	Gene	compound|appos|START_ENTITY effects|nmod|compound tested|dobj|effects tested|advcl|determine determine|ccomp|controls controls|nsubj|END_ENTITY	To determine whether Rac1 controls actin nucleation in Silvetia compressa -LRB- J. Agardh -RRB- E. Serrao , T. O. Cho , S. M. Boo et Brawley , we tested the effects of the Rac1-specific inhibitory compound , NSC23766 , on actin dependent processes and on actin arrays .
23887096	0	NSC23766	0,8	Rac1	37,41	NSC23766	Rac1	MESH:C487513	5879	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|activation activation|amod|END_ENTITY	NSC23766 , a widely used inhibitor of Rac1 activation , additionally acts as a competitive antagonist at muscarinic acetylcholine receptors .
24257023	0	NSC23766	53,61	Rac1	14,18	NSC23766	Rac1	MESH:C487513	5879	Chemical	Gene	release|nmod|START_ENTITY activity|nmod|release activity|amod|END_ENTITY	Inhibition of Rac1 activity by controlled release of NSC23766 from chitosan microspheres effectively ameliorates osteoarthritis development in vivo .
25154784	0	NSC23766	75,83	Rac1	60,64	NSC23766	Rac1	MESH:C487513	363875(Tax:10116)	Chemical	Gene	Differentiation|compound|START_ENTITY Differentiation|compound|END_ENTITY	Programmed Application of Transforming Growth Factor b3 and Rac1 Inhibitor NSC23766 Committed Hyaline Cartilage Differentiation of Adipose-Derived Stem Cells for Osteochondral Defect Repair .
25628054	0	NSC23766	63,71	Rac1	47,51	NSC23766	Rac1	MESH:C487513	19353(Tax:10090)	Chemical	Gene	inhibitors|dobj|START_ENTITY inhibitors|nsubj|effects effects|nmod|END_ENTITY	Critical off-target effects of the widely used Rac1 inhibitors NSC23766 and EHT1864 in mouse platelets .
19177354	0	NSC_109555	57,67	checkpoint_kinase_2	21,40	NSC 109555	checkpoint kinase 2	MESH:C100261	11200	Chemical	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Crystal structure of checkpoint_kinase_2 in complex with NSC_109555 , a potent and selective inhibitor .
19236100	0	NSC_622124	0,10	Eg5	26,29	NSC 622124	Eg5	MESH:C550252	3832	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	NSC_622124 inhibits human Eg5 and other kinesins via interaction with the conserved microtubule-binding site .
20515076	0	NSC_724998	93,103	topoisomerase_I	113,128	NSC 724998	topoisomerase I	MESH:C553898	7150	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Proteomic analysis of nuclei isolated from cancer cell lines treated with indenoisoquinoline NSC_724998 , a novel topoisomerase_I inhibitor .
25776905	0	NSC_743400	77,87	topoisomerase_I	50,65	NSC 743400	topoisomerase I	MESH:C551305	477229(Tax:9615)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Plasma pharmacokinetics of the indenoisoquinoline topoisomerase_I inhibitor , NSC_743400 , in rats and dogs .
20032394	0	NSITC	32,37	cathepsin_L	50,61	NSITC	cathepsin L	null	13039(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	The anti-angiogenic activity of NSITC , a specific cathepsin_L inhibitor .
9665655	0	NS_398	68,74	cyclooxygenase-2	33,49	NS 398	cyclooxygenase-2	MESH:C080955	29527(Tax:10116)	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|effect effect|nmod|END_ENTITY	Differential effect of selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitor NS_398 and diclofenac on formalin-induced nociception in the rat .
11139322	0	NU1025	74,80	PARP	58,62	NU1025	PARP	MESH:C115774	11545(Tax:10090)	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|effects effects|nmod|polymerase polymerase|appos|END_ENTITY	Differential effects of the poly _ -LRB- ADP-ribose -RRB- polymerase -LRB- PARP -RRB- inhibitor NU1025 on topoisomerase I and II inhibitor cytotoxicity in L1210 cells in vitro .
16935310	0	NU1025	27,33	PARP	37,41	NU1025	PARP	MESH:C115774	25591(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Neuroprotective effects of NU1025 , a PARP inhibitor in cerebral_ischemia are mediated through reduction in NAD depletion and DNA fragmentation .
21730979	0	NU6027	63,69	ATR	48,51	NU6027	ATR	MESH:C475622	545	Chemical	Gene	inhibitor|appos|START_ENTITY END_ENTITY|dobj|inhibitor	Identification and evaluation of a potent novel ATR inhibitor , NU6027 , in breast_and_ovarian_cancer cell lines .
15010369	0	NU7026	48,54	DNA-dependent_protein_kinase	8,36	NU7026	DNA-dependent protein kinase	MESH:C479235	5591	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	A novel DNA-dependent_protein_kinase inhibitor , NU7026 , potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia .
17351105	0	NU7026	126,132	DNA-dependent_protein_kinase	206,234	NU7026	DNA-dependent protein kinase	MESH:C479235	5591	Chemical	Gene	chomen-4-one|dep|START_ENTITY h|amod|chomen-4-one morpholin-4-yl|dep|h mediated|nsubj|morpholin-4-yl mediated|dobj|inhibition inhibition|nmod|repair repair|nmod|inhibition inhibition|nmod|END_ENTITY	Chlorambucil cytotoxicity in malignant B lymphocytes is synergistically increased by 2 - -LRB- morpholin-4-yl -RRB- - benzo -LSB- h -RSB- chomen-4-one -LRB- NU7026 -RRB- - mediated inhibition of DNA double-strand break repair via inhibition of DNA-dependent_protein_kinase .
24764698	0	NU7026	54,60	dna-dependent_protein_kinase	11,39	NU7026	dna-dependent protein kinase	MESH:C479235	5591	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|inhibition inhibition|amod|END_ENTITY	Effects of dna-dependent_protein_kinase inhibition by NU7026 on dna repair and cell survival in irradiated gastric_cancer cell line N87 .
15546735	0	NU7441	97,103	DNA-PK	78,84	NU7441	DNA-PK	MESH:C499693	5591	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|appos|END_ENTITY	Identification of a highly potent and selective DNA-dependent_protein_kinase -LRB- DNA-PK -RRB- inhibitor -LRB- NU7441 -RRB- by screening of chromenone libraries .
21630086	0	NU7441	75,81	DNA-PK	57,63	NU7441	DNA-PK	MESH:C499693	5591	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Further characterisation of the cellular activity of the DNA-PK inhibitor , NU7441 , reveals potential cross-talk with homologous recombination .
24292814	0	NU7441	21,27	DNA-PK	0,6	NU7441	DNA-PK	MESH:C499693	5591	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	DNA-PK inhibition by NU7441 sensitizes breast_cancer cells to ionizing radiation and doxorubicin .
16707462	0	NU7441	80,86	DNA-dependent_protein_kinase	41,69	NU7441	DNA-dependent protein kinase	MESH:C499693	5591	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|evaluation evaluation|nmod|END_ENTITY	Preclinical evaluation of a potent novel DNA-dependent_protein_kinase inhibitor NU7441 .
24100951	0	NU7441	95,101	DNA-dependent_protein_kinase	55,83	NU7441	DNA-dependent protein kinase	MESH:C499693	5591	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Radio-sensitization of human leukaemic MOLT-4 cells by DNA-dependent_protein_kinase inhibitor , NU7441 .
23056207	0	NU9056	48,54	Tip60	22,27	NU9056	Tip60	MESH:C579148	10524	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Characterisation of a Tip60 specific inhibitor , NU9056 , in prostate_cancer .
15816479	0	NUN	14,17	AKR1C2	28,34	NUN	AKR1C2	null	1646	Chemical	Gene	increased|nsubj|START_ENTITY increased|dobj|expression expression|compound|END_ENTITY	Growth factor NUN increased AKR1C2 expression by activated CDK2 related RB signal transduction pathway in human liver_cancer cell line .
21141739	0	NVP-ADW742	60,70	insulin-like_growth_factor-1_receptor	4,41	NVP-ADW742	insulin-like growth factor-1 receptor	MESH:C502355	3480	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	The insulin-like_growth_factor-1_receptor kinase inhibitor , NVP-ADW742 , suppresses survival and resistance to chemotherapy in acute_myeloid_leukemia cells .
15141010	0	NVP-ADW742	67,77	insulin-like_growth_factor-I	4,32	NVP-ADW742	insulin-like growth factor-I	MESH:C502355	3479	Chemical	Gene	START_ENTITY|compound|receptor receptor|amod|END_ENTITY	The insulin-like_growth_factor-I -LRB- IGF-I -RRB- receptor kinase inhibitor NVP-ADW742 , in combination with STI571 , delineates a spectrum of dependence of small_cell_lung_cancer on IGF-I and stem_cell_factor signaling .
15746061	0	NVP-ADW742	60,70	insulin-like_growth_factor-I	4,32	NVP-ADW742	insulin-like growth factor-I	MESH:C502355	3479	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	The insulin-like_growth_factor-I receptor kinase inhibitor , NVP-ADW742 , sensitizes small_cell_lung_cancer cell lines to the effects of chemotherapy .
23367880	0	NVP-AEW541	97,107	IGF-IR	79,85	NVP-AEW541	IGF-IR	MESH:C501177	3480	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Treatment with a combination of the ErbB -LRB- HER -RRB- family blocker afatinib and the IGF-IR inhibitor , NVP-AEW541 induces synergistic growth inhibition of human pancreatic_cancer cells .
17121898	0	NVP-AEW541	69,79	insulin-like_growth_factor_I_receptor	19,56	NVP-AEW541	insulin-like growth factor I receptor	MESH:C501177	16001(Tax:10090)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Down-regulation of insulin-like_growth_factor_I_receptor activity by NVP-AEW541 has an antitumor effect on neuroblastoma cells in vitro and in vivo .
18430202	0	NVP-AUY922	0,10	HSP90	29,34	NVP-AUY922	HSP90	MESH:C528044	3320	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	NVP-AUY922 : a small molecule HSP90 inhibitor with potent antitumor activity in preclinical breast_cancer models .
20502461	0	NVP-AUY922	24,34	HSP90	6,11	NVP-AUY922	HSP90	MESH:C528044	3320	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Novel HSP90 inhibitors , NVP-AUY922 and NVP-BEP800 , radiosensitise tumour cells through cell-cycle impairment , increased DNA damage and repair protraction .
25085789	0	NVP-AUY922	88,98	HSP90	72,77	NVP-AUY922	HSP90	MESH:C528044	3320	Chemical	Gene	PET|nsubj|START_ENTITY PET|xcomp|evaluate evaluate|dobj|effect effect|nmod|inhibitor inhibitor|compound|END_ENTITY	89Zr-trastuzumab and 89Zr-bevacizumab PET to evaluate the effect of the HSP90 inhibitor NVP-AUY922 in metastatic breast_cancer patients .
26723875	0	NVP-AUY922	21,31	HSP90	4,9	NVP-AUY922	HSP90	MESH:C528044	3320	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	The HSP90 inhibitor , NVP-AUY922 , sensitizes KRAS-mutant non-small_cell_lung_cancer with intrinsic resistance to MEK inhibitor , trametinib .
22646928	0	NVP-AUY922	33,43	Heat_shock_protein-90	0,21	NVP-AUY922	Heat shock protein-90	MESH:C528044	3320	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Heat_shock_protein-90 inhibitor , NVP-AUY922 , is effective in combination with fludarabine against chronic_lymphocytic_leukemia cells cultured on CD40L-stromal layer and inhibits their activated/proliferative phenotype .
23340178	0	NVP-AUY922	20,30	Hsp90	0,5	NVP-AUY922	Hsp90	MESH:C528044	3320	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Hsp90 inhibition by NVP-AUY922 and NVP-BEP800 decreases migration and invasion of irradiated normoxic and hypoxic_tumor cell lines .
21278787	0	NVP-AUY922	58,68	heat_shock_protein_90	26,47	NVP-AUY922	heat shock protein 90	MESH:C528044	3320	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|effects effects|nmod|END_ENTITY	Combined effects of novel heat_shock_protein_90 inhibitor NVP-AUY922 and nilotinib in a random mutagenesis screen .
21453385	0	NVP-AUY922	22,32	heat_shock_protein_90	42,63	NVP-AUY922	heat shock protein 90	MESH:C528044	3320	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Antitumor activity of NVP-AUY922 , a novel heat_shock_protein_90 inhibitor , in human gastric_cancer cells is mediated through proteasomal degradation of client proteins .
25953267	0	NVP-AUY922	58,68	heat_shock_protein_90	141,162	NVP-AUY922	heat shock protein 90	MESH:C528044	3320	Chemical	Gene	current|nmod|START_ENTITY K|amod|current activated|dobj|K activation|acl|activated activation|nmod|inhibition inhibition|amod|END_ENTITY	The potent activation of Ca -LRB- 2 + -RRB- - activated K -LRB- + -RRB- current by NVP-AUY922 in the human pancreatic duct cell line -LRB- PANC-1 -RRB- possibly independent of heat_shock_protein_90 inhibition .
19686236	0	NVP-BEP800	75,85	Hsp90	59,64	NVP-BEP800	Hsp90	MESH:C547235	3320	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|activity activity|nmod|END_ENTITY	Anti-myeloma activity of the novel 2-aminothienopyrimidine Hsp90 inhibitor NVP-BEP800 .
19010894	0	NVP-BEZ235	147,157	Phosphatidylinositol_3-kinase	0,29	NVP-BEZ235	Phosphatidylinositol 3-kinase	MESH:C531198	5290	Chemical	Gene	_|dobj|START_ENTITY _|nsubj|results results|amod|END_ENTITY	Phosphatidylinositol_3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/phosphatidylinositol _ 3-kinase inhibitor NVP-BEZ235 .
22452803	0	NVP-BEZ235	0,10	mammalian_target_of_rapamycin	62,91	NVP-BEZ235	mammalian target of rapamycin	MESH:C531198	2475	Chemical	Gene	START_ENTITY|appos|inhibitors inhibitors|compound|END_ENTITY	NVP-BEZ235 and NVP-BGT226 , dual phosphatidylinositol_3-kinase / mammalian_target_of_rapamycin inhibitors , enhance tumor and endothelial cell radiosensitivity .
22989521	0	NVP-BEZ235	150,160	mammalian_target_of_rapamycin	110,139	NVP-BEZ235	mammalian target of rapamycin	MESH:C531198	2475	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|Inhibition Inhibition|nmod|autophagy autophagy|nmod|strategy strategy|acl|augment augment|nmod|END_ENTITY	Inhibition of autophagy as a strategy to augment radiosensitization by the dual phosphatidylinositol_3-kinase / mammalian_target_of_rapamycin inhibitor NVP-BEZ235 .
23768063	0	NVP-BEZ235	0,10	mammalian_target_of_rapamycin	47,76	NVP-BEZ235	mammalian target of rapamycin	MESH:C531198	2475	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	NVP-BEZ235 , dual phosphatidylinositol_3-kinase / mammalian_target_of_rapamycin inhibitor , prominently enhances radiosensitivity of prostate_cancer cell line PC-3 .
18701483	0	NVP-BEZ235	90,100	phosphatidylinositol_3-kinase	20,49	NVP-BEZ235	phosphatidylinositol 3-kinase	MESH:C531198	5293	Chemical	Gene	Effects|dep|START_ENTITY Effects|nmod|END_ENTITY	Effects of the dual phosphatidylinositol_3-kinase / mammalian_target_of_rapamycin inhibitor NVP-BEZ235 on the tumor vasculature : implications for clinical imaging .
20876803	0	NVP-BEZ235	97,107	phosphatidylinositol_3-kinase	27,56	NVP-BEZ235	phosphatidylinositol 3-kinase	MESH:C531198	5293	Chemical	Gene	Activity|dep|START_ENTITY Activity|nmod|END_ENTITY	Activity of the novel dual phosphatidylinositol_3-kinase / mammalian_target_of_rapamycin inhibitor NVP-BEZ235 against T-cell_acute_lymphoblastic_leukemia .
22452803	0	NVP-BEZ235	0,10	phosphatidylinositol_3-kinase	32,61	NVP-BEZ235	phosphatidylinositol 3-kinase	MESH:C531198	5293	Chemical	Gene	START_ENTITY|appos|inhibitors inhibitors|amod|END_ENTITY	NVP-BEZ235 and NVP-BGT226 , dual phosphatidylinositol_3-kinase / mammalian_target_of_rapamycin inhibitors , enhance tumor and endothelial cell radiosensitivity .
22989521	0	NVP-BEZ235	150,160	phosphatidylinositol_3-kinase	80,109	NVP-BEZ235	phosphatidylinositol 3-kinase	MESH:C531198	5290	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|Inhibition Inhibition|nmod|autophagy autophagy|nmod|strategy strategy|acl|augment augment|nmod|mammalian_target_of_rapamycin mammalian_target_of_rapamycin|amod|END_ENTITY	Inhibition of autophagy as a strategy to augment radiosensitization by the dual phosphatidylinositol_3-kinase / mammalian_target_of_rapamycin inhibitor NVP-BEZ235 .
23768063	0	NVP-BEZ235	0,10	phosphatidylinositol_3-kinase	17,46	NVP-BEZ235	phosphatidylinositol 3-kinase	MESH:C531198	5293	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	NVP-BEZ235 , dual phosphatidylinositol_3-kinase / mammalian_target_of_rapamycin inhibitor , prominently enhances radiosensitivity of prostate_cancer cell line PC-3 .
25637161	0	NVP-BEZ235	75,85	phosphatidylinositol_3-kinase	5,34	NVP-BEZ235	phosphatidylinositol 3-kinase	MESH:C531198	5293	Chemical	Gene	synergizes|nsubj|START_ENTITY END_ENTITY|parataxis|synergizes	Dual phosphatidylinositol_3-kinase / mammalian_target_of_rapamycin inhibitor NVP-BEZ235 synergizes with chloroquine to induce apoptosis in embryonal_rhabdomyosarcoma .
25869769	0	NVP-BEZ235	97,107	phosphatidylinositol_3-kinase	27,56	NVP-BEZ235	phosphatidylinositol 3-kinase	MESH:C531198	5293	Chemical	Gene	Activity|dep|START_ENTITY Activity|nmod|END_ENTITY	Activity of the novel dual phosphatidylinositol_3-kinase / mammalian_target_of_rapamycin inhibitor NVP-BEZ235 against osteosarcoma .
21976531	0	NVP-BGT226	53,63	mTOR	32,36	NVP-BGT226	mTOR	MESH:C570852	21977(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Novel phosphoinositide_3-kinase / mTOR dual inhibitor , NVP-BGT226 , displays potent growth-inhibitory activity against human head_and_neck_cancer cells in vitro and in vivo .
20803239	0	NVP-BHG712	51,61	VEGF	71,75	NVP-BHG712	VEGF	null	7422	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesis .
24741074	0	NVP-BKM120	61,71	AKT	44,47	NVP-BKM120	AKT	MESH:C571178	207	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Inhibition of phosphatidylinositol_3-kinase / AKT signaling by NVP-BKM120 promotes ABT-737-induced toxicity in a caspase-dependent manner through mitochondrial_dysfunction and DNA damage response in established and primary cultured_glioblastoma cells .
23562472	0	NVP-BKM120	25,35	Mcl-1	65,70	NVP-BKM120	Mcl-1	MESH:C571178	4170	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|degradation degradation|amod|END_ENTITY	The PI3 kinase inhibitor NVP-BKM120 induces GSK3/FBXW7-dependent Mcl-1 degradation , contributing to induction of apoptosis and enhancement of TRAIL-induced apoptosis .
22159814	0	NVP-BKM120	0,10	PI3K	20,24	NVP-BKM120	PI3K	MESH:C571178	5293	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	NVP-BKM120 , a novel PI3K inhibitor , shows synergism with a STAT3 inhibitor in human gastric_cancer cells harboring KRAS mutations .
24337846	0	NVP-BKM120	26,36	PI3K	11,15	NVP-BKM120	PI3K	MESH:C571178	5293	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|Effects Effects|nmod|END_ENTITY	Effects of PI3K inhibitor NVP-BKM120 on acquired resistance to gefitinib of human lung_adenocarcinoma H1975 cells .
8614253	0	NW-nitro-L-arginine_methylester	36,67	catalase	85,93	NW-nitro-L-arginine methylester	catalase	null	847	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|activity activity|compound|END_ENTITY	The nitric_oxide synthase inhibitor NW-nitro-L-arginine_methylester attenuates brain catalase activity in vitro .
24092395	0	NXD30001	40,48	HSP90	23,28	NXD30001	HSP90	MESH:C555907	111058(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	A novel small molecule HSP90 inhibitor , NXD30001 , differentially induces heat_shock proteins in nervous tissue in culture and in vivo .
23155193	0	NXN-188	0,7	CGRP	79,83	NXN-188	CGRP	null	24241(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|compound|END_ENTITY	NXN-188 , a selective nNOS inhibitor and a 5-HT1B / 1D receptor agonist , inhibits CGRP release in preclinical migraine models .
23155193	0	NXN-188	0,7	nNOS	21,25	NXN-188	nNOS	null	24598(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	NXN-188 , a selective nNOS inhibitor and a 5-HT1B / 1D receptor agonist , inhibits CGRP release in preclinical migraine models .
11911866	0	NXY-059	10,17	cyclosporin_A	105,118	NXY-059	cyclosporin A	MESH:C120851	1161	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|comparison comparison|nmod|END_ENTITY	Effect of NXY-059 on secondary mitochondrial dysfunction after transient focal ischemia ; comparison with cyclosporin_A .
26337079	0	NZ51	0,4	DDX3	126,130	NZ51	DDX3	null	1654	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	NZ51 , a ring-expanded nucleoside analog , inhibits motility and viability of breast_cancer cells by targeting the RNA helicase DDX3 .
8568562	0	N_alpha-2-naphthylsulfonyl-L-3-amidino-phenylalanyl-4-methylpiperidide	56,126	thrombin	31,39	N alpha-2-naphthylsulfonyl-L-3-amidino-phenylalanyl-4-methylpiperidide	thrombin	null	280685(Tax:9913)	Chemical	Gene	complex|nmod|START_ENTITY END_ENTITY|nmod|complex	The X-ray crystal structure of thrombin in complex with N_alpha-2-naphthylsulfonyl-L-3-amidino-phenylalanyl-4-methylpiperidide : the beneficial effect of filling out an empty cavity .
3559981	0	N_alpha-acetyl-beta-endorphin	0,29	ornithine_decarboxylase	41,64	N alpha-acetyl-beta-endorphin	ornithine decarboxylase	null	24609(Tax:10116)	Chemical	Gene	stimulates|amod|START_ENTITY END_ENTITY|nsubj|stimulates	N_alpha-acetyl-beta-endorphin stimulates ornithine_decarboxylase activity in preweanling rat pups : opioid - and non-opioid-mediated mechanisms .
1383377	0	N_omega-amino-L-arginine	0,24	nitric_oxide_synthase	42,63	N omega-amino-L-arginine	nitric oxide synthase	null	4843	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	N_omega-amino-L-arginine , an inhibitor of nitric_oxide_synthase , raises vascular resistance but increases mortality rates in awake canines challenged with endotoxin .
7900848	0	Na	23,25	CCT	42,45	Na	CCT	null	314323(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|nmod|END_ENTITY	Feedback regulation of Na channels in rat CCT .
8384417	0	Na	23,25	CCT	42,45	Na	CCT	null	314323(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|nmod|END_ENTITY	Feedback regulation of Na channels in rat CCT .
8384418	0	Na	23,25	CCT	42,45	Na	CCT	null	314323(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|nmod|END_ENTITY	Feedback regulation of Na channels in rat CCT .
17176442	0	Na	0,2	CD298	28,33	Na	CD298	null	483	Chemical	Gene	subunit|compound|START_ENTITY subunit|appos|END_ENTITY	Na , K ATPase beta3 subunit -LRB- CD298 -RRB- : association with alpha subunit and expression on peripheral blood cells .
3607460	0	Na	71,73	CSF	67,70	Na	CSF	null	116630(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY concentration|compound|END_ENTITY	Inhibition of dehydration induced drinking in rats by reduction of CSF Na concentration .
22357920	7	Na	985,987	ENaC	997,1001	Na	ENaC	null	20276(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Inhibition of epithelial Na channel -LRB- ENaC -RRB- with amiloride or benzamil abolished the flow response , suggesting involvement of ENaC in flow-regulated ET-1 synthesis .
15745941	0	Na	49,51	EP4	28,31	Na	EP4	null	84023(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	The selective prostaglandin EP4 agonist , APS-999 Na , induces follicular growth and maturation in the rat ovary .
1329533	0	Na	45,47	Insulin	0,7	Na	Insulin	null	3630	Chemical	Gene	channels|compound|START_ENTITY activates|dobj|channels activates|nsubj|END_ENTITY	Insulin activates single amiloride-blockable Na channels in a distal nephron cell line -LRB- A6 -RRB- .
2552816	0	Na	36,38	Insulin	0,7	Na	Insulin	null	3630	Chemical	Gene	transport|compound|START_ENTITY transport|compound|END_ENTITY	Insulin and IGF_I_receptor-mediated Na + transport in toad urinary bladders .
8366505	0	Na	99,101	Insulin	0,7	Na	Insulin	null	3630	Chemical	Gene	transport|compound|START_ENTITY regulation|nmod|transport receptors|dep|regulation receptors|compound|END_ENTITY	Insulin and IGE-1 receptors in a human intestinal_adenocarcinoma cell line -LRB- CACO-2 -RRB- : regulation of Na + glucose transport across the brush border .
10444581	0	Na	22,24	NHE-3	38,43	Na	NHE-3	null	24784(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY transporters|nsubj|expression transporters|dobj|END_ENTITY	Altered expression of Na transporters NHE-3 , NaPi-II , Na-K-ATPase , BSC-1 , and TSC in CRF rat kidneys .
20376516	0	Na	10,12	Na-Cl_cotransporter	34,53	Na	Na-Cl cotransporter	null	6559	Chemical	Gene	reabsorption|compound|START_ENTITY reabsorption|nmod|END_ENTITY	Increased Na reabsorption via the Na-Cl_cotransporter in autosomal recessive pseudohypoaldosteronism .
9671787	0	Na	27,29	NaN	0,3	Na	NaN	null	11280	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|appos|channel	NaN , a novel voltage-gated Na channel , is expressed preferentially in peripheral sensory neurons and down-regulated after axotomy .
18632931	0	Na	115,117	SCN1A	108,113	Na	SCN1A	null	6323	Chemical	Gene	channel|compound|START_ENTITY channel|amod|.1 .1|dep|END_ENTITY	Self-limited hyperexcitability : functional effect of a familial hemiplegic_migraine mutation of the Nav1 .1 -LRB- SCN1A -RRB- Na + channel .
18386309	0	Na	36,38	SCN5A	23,28	Na	SCN5A	null	25665(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|nummod|END_ENTITY	New variants of Nav1 .5 / SCN5A encode Na + channels in the brain .
21555511	0	Na	0,2	Scn1b	12,17	Na	Scn1b	null	20266(Tax:10090)	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Na + channel Scn1b gene regulates dorsal root ganglion nociceptor excitability in vivo .
19326446	0	Na	108,110	Scn7a	120,125	Na	Scn7a	null	20272(Tax:10090)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification and functional characterization of the promoter of the mouse sodium-activated sodium channel Na -LRB- x -RRB- gene -LRB- Scn7a -RRB- .
21636576	0	Na	57,59	Slc6a19	95,102	Na	Slc6a19	null	74338(Tax:10090)	Chemical	Gene	cotransporter|compound|START_ENTITY cotransporter|appos|END_ENTITY	Impaired nutrient signaling and body weight control in a Na + neutral amino_acid cotransporter -LRB- Slc6a19 -RRB- - deficient mouse .
6974506	0	Na	60,62	Vasopressin	0,11	Na	Vasopressin	null	551	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|nmod|transport	Vasopressin , theophylline , PGE2 , and indomethacin on active Na transport in frog skin : studies with microelectrodes .
17176442	0	Na	0,2	beta3	13,18	Na	beta3	null	1934	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	Na , K ATPase beta3 subunit -LRB- CD298 -RRB- : association with alpha subunit and expression on peripheral blood cells .
2785069	0	Na	34,36	prolactin	10,19	Na	prolactin	null	5617	Chemical	Gene	transport|compound|START_ENTITY Effect|nmod|transport Effect|nmod|END_ENTITY	Effect of prolactin on the active Na transport across Rana catesbeiana skin during metamorphosis .
2879679	0	Na	49,51	prolactin	25,34	Na	prolactin	null	5617	Chemical	Gene	system|compound|START_ENTITY effect|nmod|system effect|nmod|END_ENTITY	The short-term effect of prolactin on the active Na transport system of the tadpole skin during metamorphosis .
3360287	0	Na	38,40	prolactin	10,19	Na	prolactin	null	5617	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|nmod|transport	Effect of prolactin on transcutaneous Na transport in the Japanese newt , Cynops pyrrhogaster .
3935895	0	Na	30,32	renin	50,55	Na	renin	null	24715(Tax:10116)	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|secretion secretion|compound|END_ENTITY	Does decreasing extracellular Na inhibit in vitro renin secretion by affecting Na-Ca exchange ?
7673182	0	Na	4,6	thrombin	24,32	Na	thrombin	null	2147	Chemical	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	The Na + binding site of thrombin .
14716489	0	Na,K-ATP	15,23	SGK1	0,4	Na,K-ATP	SGK1	null	399130(Tax:8355)	Chemical	Gene	START_ENTITY|nsubj|increases increases|compound|END_ENTITY	SGK1 increases Na,K-ATP cell-surface expression and function in Xenopus_laevis oocytes .
11352650	0	Na-Cl	64,69	SLC12A3	85,92	Na-Cl	SLC12A3	CHEBI:26710	6559	Chemical	Gene	Sequencing|nmod|START_ENTITY cotransporter|nsubj|Sequencing cotransporter|xcomp|promoter promoter|dep|END_ENTITY	Sequencing and characterization of the human thiazide-sensitive Na-Cl cotransporter -LRB- SLC12A3 -RRB- gene promoter .
17873326	0	Na-Cl	46,51	SLC12A3	67,74	Na-Cl	SLC12A3	CHEBI:26710	6559	Chemical	Gene	cotransporter|amod|START_ENTITY cotransporter|appos|END_ENTITY	Two novel genotypes of the thiazide-sensitive Na-Cl cotransporter -LRB- SLC12A3 -RRB- gene in patients with Gitelman 's _ syndrome .
19489442	0	Na-Cl	45,50	SLC12A3	66,73	Na-Cl	SLC12A3	CHEBI:26710	6559	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	-LSB- Mutational analysis of a thiazide-sensitive Na-Cl cotransporter -LRB- SLC12A3 -RRB- gene in a Japanese population -- the Iwaki Health Promotion Project -RSB- .
11457581	0	Na-K-2Cl	97,105	NKCC1	121,126	Na-K-2Cl	NKCC1	null	83629(Tax:10116)	Chemical	Gene	cotransporter|compound|START_ENTITY cotransporter|appos|END_ENTITY	The differential expression patterns of messenger RNAs encoding K-Cl cotransporters -LRB- KCC1 ,2 -RRB- and Na-K-2Cl cotransporter -LRB- NKCC1 -RRB- in the rat nervous system .
12040017	0	Na-K-Cl	43,50	NKCC1	66,71	Na-K-Cl	NKCC1	null	20496(Tax:10090)	Chemical	Gene	cotransporter|amod|START_ENTITY cotransporter|appos|END_ENTITY	Mouse mammary epithelial cells express the Na-K-Cl cotransporter , NKCC1 : characterization , localization , and involvement in ductal development and morphogenesis .
12145304	0	Na-K-Cl	63,70	NKCC1	86,91	Na-K-Cl	NKCC1	null	6558	Chemical	Gene	cotransporter|amod|START_ENTITY cotransporter|appos|END_ENTITY	A regulatory locus of phosphorylation in the N terminus of the Na-K-Cl cotransporter , NKCC1 .
18045874	0	Na-K-Cl	103,110	NKCC1	126,131	Na-K-Cl	NKCC1	null	6558	Chemical	Gene	cotransporter|compound|START_ENTITY cotransporter|appos|END_ENTITY	Intramolecular and intermolecular fluorescence resonance energy transfer in fluorescent protein-tagged Na-K-Cl cotransporter -LRB- NKCC1 -RRB- : sensitivity to regulatory conformational change and cell volume .
8770947	0	Na-K-Cl	27,34	rBSC1	50,55	Na-K-Cl	rBSC1	null	25065(Tax:10116)	Chemical	Gene	cotransporter|amod|START_ENTITY cotransporter|appos|END_ENTITY	Apical localization of the Na-K-Cl cotransporter , rBSC1 , on rat thick ascending limbs .
8414907	0	Na-Pi	26,31	NaPi-1	16,22	Na-Pi	NaPi-1	null	100009144(Tax:9986)	Chemical	Gene	cotransporter|amod|START_ENTITY END_ENTITY|appos|cotransporter	Localization of NaPi-1 , a Na-Pi cotransporter , in rabbit kidney proximal tubules .
8414908	0	Na/Pi	26,31	NaPi-1	16,22	Na/Pi	NaPi-1	null	100009144(Tax:9986)	Chemical	Gene	cotransporter|compound|START_ENTITY END_ENTITY|appos|cotransporter	Localization of NaPi-1 , a Na/Pi cotransporter , in rabbit kidney proximal tubules .
25577083	0	Na6PMo11FeO40	23,36	tyrosinase	51,61	Na6PMo11FeO40	tyrosinase	null	7299	Chemical	Gene	study|nmod|START_ENTITY END_ENTITY|nsubj|study	Functionality study of Na6PMo11FeO40 as a mushroom tyrosinase inhibitor .
2422780	0	NaC1	10,14	thrombin	41,49	NaC1	thrombin	null	280685(Tax:9913)	Chemical	Gene	START_ENTITY|nmod|inactivation inactivation|nmod|END_ENTITY	Effect of NaC1 on inactivation of bovine thrombin by antithrombin_III in the presence of low affinity-heparin or dextran sulfate .
2521430	0	NaCl	13,17	ANF	0,3	NaCl	ANF	CHEBI:26710	24602(Tax:10116)	Chemical	Gene	absorption|compound|START_ENTITY inhibits|dobj|absorption inhibits|nsubj|END_ENTITY	ANF inhibits NaCl and fluid absorption in cortical collecting duct of rat kidney .
2528888	0	NaCl	46,50	Atrial_natriuretic_peptide	0,26	NaCl	Atrial natriuretic peptide	CHEBI:26710	24602(Tax:10116)	Chemical	Gene	response|nmod|START_ENTITY END_ENTITY|dep|response	Atrial_natriuretic_peptide -LRB- ANP -RRB- : response to NaCl is attenuated in rat atria in vitro after hypophysectomy .
11914383	0	NaCl	0,4	CFTR	95,99	NaCl	CFTR	CHEBI:26710	105927055	Chemical	Gene	secretion|amod|START_ENTITY secretion|dep|involvement involvement|nmod|END_ENTITY	NaCl and fluid secretion by the intestine of the teleost Fundulus_heteroclitus : involvement of CFTR .
10383997	0	NaCl	82,86	Glycerol-3-phosphate_Dehydrogenase	44,78	NaCl	Glycerol-3-phosphate Dehydrogenase	CHEBI:26710	854651(Tax:4932)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Osmoregulation and the Genetic Induction of Glycerol-3-phosphate_Dehydrogenase by NaCl in the Euryhaline Yeast Debaryomyces_hansenii .
8067387	0	NaCl	19,23	Insulin	0,7	NaCl	Insulin	CHEBI:26710	100009181(Tax:9986)	Chemical	Gene	transport|amod|START_ENTITY stimulates|dobj|transport stimulates|nsubj|END_ENTITY	Insulin stimulates NaCl transport in isolated perfused MTAL of Henle 's loop of rabbit kidney .
16728507	0	NaCl	65,69	Phosphatidylinositol_3-kinase	0,29	NaCl	Phosphatidylinositol 3-kinase	D012965	5290	Chemical	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Phosphatidylinositol_3-kinase mediates activation of ATM by high NaCl and by ionizing radiation : Role in osmoprotective transcriptional regulation .
464083	0	NaCl	73,77	Renin	0,5	NaCl	Renin	CHEBI:26710	24715(Tax:10116)	Chemical	Gene	intake|compound|START_ENTITY relation|nmod|intake secretions|dep|relation secretions|compound|END_ENTITY	Renin and aldosterone secretions during hypovolemia in rats : relation to NaCl intake .
6284847	0	NaCl	46,50	Renin	0,5	NaCl	Renin	CHEBI:26710	5972	Chemical	Gene	responses|nmod|START_ENTITY responses|compound|END_ENTITY	Renin and aldosterone responses to short-term NaCl or NaHCO3 loading in man .
15077627	0	NaCl	39,43	SOD	23,26	NaCl	SOD	CHEBI:26710	6647	Chemical	Gene	isoforms|nmod|START_ENTITY isoforms|nsubj|regulation regulation|nmod|END_ENTITY	Specific regulation of SOD isoforms by NaCl and osmotic stress in leaves of the C3 halophyte Suaeda salsa L .
3593383	0	NaCl	13,17	acetylcholinesterase	63,83	NaCl	acetylcholinesterase	CHEBI:26710	100009390(Tax:9986)	Chemical	Gene	Influence|nmod|START_ENTITY END_ENTITY|nsubj|Influence	Influence of NaCl on the kinetic behaviour of mammalian muscle acetylcholinesterase .
14718364	0	NaCl	8,12	aminopeptidase_N	29,45	NaCl	aminopeptidase N	CHEBI:26710	81641(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Dietary NaCl regulates renal aminopeptidase_N : relevance to hypertension in the Dahl rat .
7043019	0	NaCl	117,121	angiotensin_II	18,32	NaCl	angiotensin II	CHEBI:26710	24179(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of brain angiotensin_II in the mechanism of the pressor responses to intracisternal injection of hypertonic NaCl in urethane anesthetized rats .
1348507	0	NaCl	14,18	atrial_natriuretic_peptide	22,48	NaCl	atrial natriuretic peptide	CHEBI:26710	281355(Tax:9913)	Chemical	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	Modulation by NaCl of atrial_natriuretic_peptide receptor levels and cyclic_GMP responsiveness to atrial_natriuretic_peptide of cultured vascular endothelial cells .
1348507	0	NaCl	14,18	atrial_natriuretic_peptide	98,124	NaCl	atrial natriuretic peptide	CHEBI:26710	281355(Tax:9913)	Chemical	Gene	Modulation|nmod|START_ENTITY responsiveness|nsubj|Modulation responsiveness|xcomp|END_ENTITY	Modulation by NaCl of atrial_natriuretic_peptide receptor levels and cyclic_GMP responsiveness to atrial_natriuretic_peptide of cultured vascular endothelial cells .
1401336	0	NaCl	45,49	atrial_natriuretic_peptide	15,41	NaCl	atrial natriuretic peptide	CHEBI:26710	24602(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|nmod|transport	Effects of eel atrial_natriuretic_peptide on NaCl and water transport across the intestine of the seawater eel .
2969976	0	NaCl	128,132	atrial_natriuretic_peptide	165,191	NaCl	atrial natriuretic peptide	CHEBI:26710	24602(Tax:10116)	Chemical	Gene	rats|compound|START_ENTITY related|nsubjpass|rats related|xcomp|END_ENTITY	Blunted pressor responsiveness to quinpirole , a specific dopamine D2 receptor agonist , in conscious deoxycorticosterone_acetate / NaCl hypertensive rats is related to atrial_natriuretic_peptide release .
1504091	0	NaCl	10,14	myoglobin	105,114	NaCl	myoglobin	CHEBI:26710	4151	Chemical	Gene	addition|amod|START_ENTITY Effect|nmod|addition Effect|dep|evidences evidences|nmod|transition transition|nmod|structure structure|amod|END_ENTITY	Effect of NaCl addition on nanosecond O2 escaping reaction of myoglobin : evidences for the transition of myoglobin dynamic structure at 20 degrees C .
1504091	0	NaCl	10,14	myoglobin	62,71	NaCl	myoglobin	CHEBI:26710	4151	Chemical	Gene	addition|amod|START_ENTITY addition|nmod|O2 O2|acl|escaping escaping|dobj|reaction reaction|nmod|END_ENTITY	Effect of NaCl addition on nanosecond O2 escaping reaction of myoglobin : evidences for the transition of myoglobin dynamic structure at 20 degrees C .
19904983	0	NaCl	10,14	myoglobin	16,25	NaCl	myoglobin	CHEBI:26710	418056(Tax:9031)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of NaCl , myoglobin , Fe -LRB- II -RRB- , and Fe -LRB- III -RRB- on lipid oxidation of raw and cooked chicken_breast and beef loin .
25617595	0	NaCl	67,71	oxytocin	20,28	NaCl	oxytocin	CHEBI:26710	5020	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|effects effects|nmod|END_ENTITY	Opposite effects of oxytocin on water intake induced by hypertonic NaCl or polyethylene_glycol administration .
10564233	3	NaCl	542,546	renin	610,615	NaCl	COX-1	CHEBI:26710	4512	Chemical	Gene	reduction|nmod|START_ENTITY caused|nsubj|reduction caused|dobj|increase increase|nmod|rate rate|compound|END_ENTITY	In the absence of COX inhibitors , a reduction in luminal NaCl -LRB- from Na 141/Cl 120 mM to Na 26/Cl 7 mM -RRB- caused an increase in renin secretion rate from 4.5 + / - 1.8 to 26.1 + / - 7.4 nGU/min -LRB- P < 0.01 , n = 19 -RRB- .
1708028	0	NaCl	42,46	renin	53,58	NaCl	renin	CHEBI:26710	24715(Tax:10116)	Chemical	Gene	load|compound|START_ENTITY handling|nmod|load appetite|appos|handling appetite|appos|rats rats|compound|END_ENTITY	Salt appetite , body sodium , handling of a NaCl load , renin , and aldosterone in genetically and spontaneously hypertensive rats .
3318496	0	NaCl	36,40	renin	11,16	NaCl	renin	CHEBI:26710	24715(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|Control Control|nmod|END_ENTITY	Control of renin release by dietary NaCl in the rat .
3885682	0	NaCl	33,37	renin	86,91	NaCl	renin	CHEBI:26710	24715(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|activity activity|compound|END_ENTITY	Circadian rhythms of food and 1 % NaCl intake , urine and electrolyte excretion , plasma renin activity and insulin concentration in adrenalectomized rats .
6337502	0	NaCl	11,15	renin	19,24	NaCl	renin	CHEBI:26710	5972	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|responses responses|compound|END_ENTITY	Effects of NaCl on renin and aldosterone responses to potassium depletion .
7607716	0	NaCl	43,47	renin	84,89	NaCl	renin	CHEBI:26710	100358545(Tax:9986)	Chemical	Gene	dependency|compound|START_ENTITY Effects|nmod|dependency Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of furosemide and verapamil on the NaCl dependency of macula densa-mediated renin secretion .
8272384	0	NaCl	21,25	renin	36,41	NaCl	renin	CHEBI:26710	24715(Tax:10116)	Chemical	Gene	intake|amod|START_ENTITY Influence|nmod|intake Influence|nmod|expression expression|compound|END_ENTITY	Influence of dietary NaCl intake on renin gene expression in the kidneys and adrenal glands of rats .
9435677	0	NaCl	86,90	renin	45,50	NaCl	renin	CHEBI:26710	24715(Tax:10116)	Chemical	Gene	changes|nmod|START_ENTITY tubule|nmod|changes tubule|dobj|mRNA mRNA|compound|END_ENTITY	Regulation of glomerular and proximal tubule renin mRNA by chronic changes in dietary NaCl .
19506077	0	NaKtide	0,7	Src	39,42	NaKtide	Src	null	6714	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	NaKtide , a Na/K-ATPase-derived peptide Src inhibitor , antagonizes ouabain-activated signal transduction in cultured cells .
15171701	0	NaPi-III	43,51	Pit-1	65,70	NaPi-III	Pit-1	null	25517(Tax:10116)	Chemical	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	Regulation of phosphate -LRB- Pi -RRB- transport and NaPi-III transporter -LRB- Pit-1 -RRB- mRNA in rat osteoblasts .
15581846	0	NaPi-IIa	29,37	angiotensin_II	11,25	NaPi-IIa	angiotensin II	null	24179(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Effects of angiotensin_II on NaPi-IIa co-transporter expression and activity in rat renal cortex .
9748366	0	Naamidine_A	0,11	epidermal_growth_factor_receptor	36,68	Naamidine A	epidermal growth factor receptor	MESH:C114816	13649(Tax:10090)	Chemical	Gene	antagonist|nsubj|START_ENTITY antagonist|nmod|END_ENTITY	Naamidine_A is an antagonist of the epidermal_growth_factor_receptor and an in vivo active antitumor agent .
8531087	0	Nafadotride	0,11	dopamine_D3_receptor	35,55	Nafadotride	dopamine D3 receptor	MESH:C097285	13490(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Nafadotride , a potent preferential dopamine_D3_receptor antagonist , activates locomotion in rodents .
17458645	0	Nafamostat_mesilate	0,19	HMGB1	47,52	Nafamostat mesilate	HMGB1	MESH:C032855	25459(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Nafamostat_mesilate inhibits the expression of HMGB1 in lipopolysaccharide-induced acute lung_injury .
17458645	0	Nafamostat_mesilate	0,19	HMGB1	47,52	Nafamostat mesilate	HMGB1	MESH:C032855	25459(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Nafamostat_mesilate inhibits the expression of HMGB1 in lipopolysaccharide-induced acute lung_injury .
25940319	0	Nafamostat_mesilate	20,39	HMGB1	67,72	Nafamostat mesilate	HMGB1	MESH:C032855	3146	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Retraction Note to : Nafamostat_mesilate inhibits the expression of HMGB1 in lipopolysaccharide-induced acute_lung_injury .
17414427	0	Nafamostat_mesilate	0,19	high-mobility_group_box_1	29,54	Nafamostat mesilate	high-mobility group box 1	MESH:C032855	15289(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Nafamostat_mesilate inhibits high-mobility_group_box_1 by lipopolysaccharide stimulation in murine macrophage RAW 264.7 .
19008643	0	Nafamostat_mesilate	0,19	serine_protease	30,45	Nafamostat mesilate	serine protease	MESH:C032855	50908(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Nafamostat_mesilate , a potent serine_protease inhibitor , inhibits airway eosinophilic inflammation and airway epithelial remodeling in a murine model of allergic_asthma .
2303313	0	Nafamstat_Mesilate	23,41	C4a	51,54	Nafamstat Mesilate	C4a	MESH:C032855	100356976(Tax:9986)	Chemical	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The effect of FUT-175 -LRB- Nafamstat_Mesilate -RRB- on C3a , C4a and C5a generation in vitro and inflammatory reactions in vivo .
2151003	0	Nafarelin_acetate	0,17	gonadotropin-releasing_hormone	21,51	Nafarelin acetate	gonadotropin-releasing hormone	MESH:D017274	2796	Chemical	Gene	START_ENTITY|dep|agonist agonist|amod|END_ENTITY	Nafarelin_acetate : a gonadotropin-releasing_hormone agonist for the treatment of endometriosis .
24061356	0	Nafion	13,19	Tyrosinase	117,127	Nafion	Tyrosinase	CHEBI:61428	7299	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of Nafion in Titania Sol-gel Matrix on Analytical Characteristic of Amperometric_Phenol Biosensor Based on Tyrosinase .
10769686	0	Nafoxidine	0,10	matrix-metalloproteinase-2	39,65	Nafoxidine	matrix-metalloproteinase-2	MESH:D009256	4313	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	Nafoxidine modulates the expression of matrix-metalloproteinase-2 -LRB- MMP-2 -RRB- and tissue_inhibitor_of_metalloproteinases-1 -LRB- TIMP-1 -RRB- in endothelial cells .
8234106	0	Naftidrofuryl	0,13	cramp	33,38	Naftidrofuryl	cramp	MESH:D009257	820	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|END_ENTITY	Naftidrofuryl treatment for rest cramp .
1429224	0	Nagstatin	0,9	N-acetyl-beta-D-glucosaminidase	30,61	Nagstatin	N-acetyl-beta-D-glucosaminidase	MESH:C077641	10724	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Nagstatin , a new inhibitor of N-acetyl-beta-D-glucosaminidase , produced by Streptomyces amakusaensis MG846-fF3 .
1750479	0	Nal-Glu	94,101	gonadotropin-releasing_hormone	51,81	Nal-Glu	gonadotropin-releasing hormone	MESH:C102118	2796	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Comparison of intermittent and continuous use of a gonadotropin-releasing_hormone antagonist -LRB- Nal-Glu -RRB- in in vitro fertilization cycles : a preliminary report .
1750480	0	Nal-Glu	47,54	gonadotropin-releasing_hormone	4,34	Nal-Glu	gonadotropin-releasing hormone	MESH:C102118	2796	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	The gonadotropin-releasing_hormone antagonist -LRB- Nal-Glu -RRB- acutely blocks the luteinizing hormone surge but allows for resumption of folliculogenesis in normal women .
1936328	0	Nal-Glu	116,123	gonadotropin-releasing_hormone	73,103	Nal-Glu	gonadotropin-releasing hormone	MESH:C102118	2796	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Prevention of premature luteinizing hormone and progesterone rise with a gonadotropin-releasing_hormone antagonist , Nal-Glu , in controlled ovarian_hyperstimulation .
7789550	0	Nal-Glu	63,70	gonadotropin-releasing_hormone	20,50	Nal-Glu	gonadotropin-releasing hormone	MESH:C102118	2796	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Dose effects of the gonadotropin-releasing_hormone antagonist , Nal-Glu , combined with testosterone_enanthate on gonadotropin levels in normal men .
9247320	4	Naloxone	651,659	Ang_II	718,724	Naloxone	Ang II	MESH:D009270	24179(Tax:10116)	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|nmod|END_ENTITY	Naloxone -LRB- 10 microg -RRB- completely inhibited the response to 6.5 nmol Ang_II .
24634599	0	Naloxone	0,8	JNK	94,97	Naloxone	JNK	MESH:D009270	116554(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|Activity Activity|compound|END_ENTITY	Naloxone Postconditioning Alleviates Rat Myocardial_Ischemia Reperfusion Injury by Inhibiting JNK Activity .
3135508	0	Naloxone	0,8	LHRH	32,36	Naloxone	LHRH	MESH:D009270	25194(Tax:10116)	Chemical	Gene	stimulation|amod|START_ENTITY stimulation|nmod|release release|compound|END_ENTITY	Naloxone stimulation of in vivo LHRH release is not diminished following ovariectomy .
3996535	0	Naloxone	0,8	alpha-MSH	42,51	Naloxone	alpha-MSH	MESH:D009270	18976(Tax:10090)	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|dobj|action action|nmod|END_ENTITY	Naloxone prevents the analgesic action of alpha-MSH in mice .
2041583	0	Naloxone	0,8	angiotensin_II	23,37	Naloxone	angiotensin II	MESH:D009270	183	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Naloxone increases the angiotensin_II stimulated rise of arginine_vasopressin and oxytocin secretion in man .
3731680	0	Naloxone	0,8	beta-endorphin	47,61	Naloxone	beta-endorphin	MESH:D009270	5443	Chemical	Gene	modify|nsubj|START_ENTITY modify|dobj|levels levels|compound|END_ENTITY	Naloxone , fentanyl , and diazepam modify plasma beta-endorphin levels during surgery .
6267643	0	Naloxone	0,8	beta-endorphin	20,34	Naloxone	beta-endorphin	MESH:D009270	5443	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|END_ENTITY	Naloxone effects on beta-endorphin , cortisol , prolactin , growth_hormone , HVA and MHPG in plasma of normal volunteers .
116298	0	Naloxone	0,8	growth_hormone	26,40	Naloxone	growth hormone	MESH:D009270	2688	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|END_ENTITY	Naloxone effects on serum growth_hormone and prolactin in man .
2533520	0	Naloxone	1,9	growth_hormone	44,58	Naloxone	growth hormone	MESH:D009270	2688	Chemical	Gene	determine|nsubj|START_ENTITY determine|dobj|response response|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Naloxone does n't determine the response of growth_hormone to clonidine in obese patients -RSB- .
2558324	0	Naloxone	0,8	growth_hormone	36,50	Naloxone	growth hormone	MESH:D009270	2688	Chemical	Gene	inhibition|amod|START_ENTITY END_ENTITY|nsubj|inhibition	Naloxone inhibition of postprandial growth_hormone releasing hormone-induced growth_hormone release in obesity .
2558324	0	Naloxone	0,8	growth_hormone	77,91	Naloxone	growth hormone	MESH:D009270	2688	Chemical	Gene	inhibition|amod|START_ENTITY growth_hormone|nsubj|inhibition growth_hormone|xcomp|releasing releasing|dobj|release release|compound|END_ENTITY	Naloxone inhibition of postprandial growth_hormone releasing hormone-induced growth_hormone release in obesity .
2881420	0	Naloxone	0,8	growth_hormone	41,55	Naloxone	growth hormone	MESH:D009270	2688	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|increase increase|nmod|END_ENTITY	Naloxone enhances the increase in plasma growth_hormone induced by alpha 2-adrenergic stimulation in healthy males .
3035002	0	Naloxone	0,8	growth_hormone	35,49	Naloxone	growth hormone	MESH:D009270	2688	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|response response|nmod|END_ENTITY	Naloxone increases the response of growth_hormone and prolactin to stimuli in obese humans .
8748046	0	Naloxone	0,8	growth_hormone	36,50	Naloxone	growth hormone	MESH:D009270	2688	Chemical	Gene	START_ENTITY|nmod|response response|amod|END_ENTITY	Naloxone and metergoline effects on growth_hormone response to gamma-hydroxybutyric_acid .
8750573	0	Naloxone	0,8	growth_hormone	26,40	Naloxone	growth hormone	MESH:D009270	2688	Chemical	Gene	influence|nsubj|START_ENTITY influence|advcl|releasing releasing|nsubj|response response|compound|END_ENTITY	Naloxone influence on the growth_hormone , prolactin and thyrotropin response to thyrotropin releasing hormone in acromegalic patients .
2046864	0	Naloxone	0,8	luteinizing_hormone-releasing_hormone	63,100	Naloxone	luteinizing hormone-releasing hormone	MESH:D009270	25194(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|frequency frequency|nmod|activity activity|nmod|generator generator|amod|END_ENTITY	Naloxone increases the frequency of the electrical activity of luteinizing_hormone-releasing_hormone pulse generator in long-term ovariectomized rats .
8431770	0	Naloxone	0,8	luteinizing_hormone-releasing_hormone	42,79	Naloxone	luteinizing hormone-releasing hormone	MESH:D009270	25194(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|nmod|END_ENTITY	Naloxone stimulates comparable release of luteinizing_hormone-releasing_hormone from tissue fragments from ovariectomized , estrogen-treated young and middle-aged female rats .
1784342	0	Naloxone	0,8	oxytocin	34,42	Naloxone	oxytocin	MESH:D009270	25504(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|release release|nmod|END_ENTITY	Naloxone increases the release of oxytocin , but not vasopressin , within limbic brain areas of conscious parturient rats : a push-pull perfusion study .
2569658	0	Naloxone	0,8	oxytocin	75,83	Naloxone	oxytocin	MESH:D009270	5020	Chemical	Gene	abolishes|nsubj|START_ENTITY abolishes|dobj|effect effect|nmod|release release|nmod|END_ENTITY	Naloxone abolishes the inhibiting effect of somatostatin on the release of oxytocin evoked by insulin-induced hypoglycemia in humans .
2723127	0	Naloxone	0,8	prolactin	56,65	Naloxone	prolactin	MESH:D009270	5617	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|stimulation stimulation|nmod|END_ENTITY	Naloxone suppresses buprenorphine stimulation of plasma prolactin .
7052489	0	Naloxone	0,8	prolactin	52,61	Naloxone	prolactin	MESH:D009270	24683(Tax:10116)	Chemical	Gene	arginine_vasotocin|amod|START_ENTITY arginine_vasotocin|dep|AVT AVT|acl|induced induced|dobj|release release|compound|END_ENTITY	Naloxone inhibits arginine_vasotocin - -LRB- AVT -RRB- induced prolactin release in urethane-anesthetized male rats in vivo .
7094361	0	Naloxone	0,8	vasopressin	51,62	Naloxone	vasopressin	MESH:D009270	551	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|rise rise|nmod|secretion secretion|compound|END_ENTITY	Naloxone increases the nicotine-stimulated rise of vasopressin secretion in man .
11311731	0	Naloxone_blocks	0,15	neuropeptide_Y	40,54	Naloxone blocks	neuropeptide Y	null	24604(Tax:10116)	Chemical	Gene	START_ENTITY|dep|effects effects|nmod|END_ENTITY	Naloxone_blocks ` anxiolytic ' effects of neuropeptide_Y .
11166066	0	Naltrexone	0,10	beta-endorphin	48,62	Naltrexone	beta-endorphin	MESH:D009271	18976(Tax:10090)	Chemical	Gene	START_ENTITY|acl|drinking drinking|nmod|mice mice|acl|lacking lacking|dobj|END_ENTITY	Naltrexone and alcohol drinking in mice lacking beta-endorphin by site-directed mutagenesis .
2137320	0	Naltrexone	0,10	beta-endorphin	74,88	Naltrexone	beta-endorphin	MESH:D009271	5443	Chemical	Gene	therapy|amod|START_ENTITY therapy|nmod|children children|nmod|END_ENTITY	Naltrexone therapy of apnea in children with elevated cerebrospinal fluid beta-endorphin .
9368834	0	Naltrexone	21,31	growth_hormone	45,59	Naltrexone	growth hormone	MESH:D009271	2688	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|END_ENTITY	Influence of chronic Naltrexone treatment on growth_hormone and insulin secretion in obese subjects .
8760232	0	Naltrexone	0,10	neuropeptide_Y	35,49	Naltrexone	neuropeptide Y	MESH:D009271	24604(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Naltrexone induces arcuate nucleus neuropeptide_Y gene expression in the rat .
9747902	0	Naltrexone	0,10	nociceptin	123,133	Naltrexone	nociceptin	MESH:D009271	5368	Chemical	Gene	antagonizes|nsubj|START_ENTITY antagonizes|nmod|END_ENTITY	Naltrexone , but not atropine or yohimbine , antagonizes suppression of formalin-induced spinal sensitization by intrathecal nociceptin .
20833755	0	Nanaomycin_A	0,12	DNMT3B	34,40	Nanaomycin A	DNMT3B	MESH:C008638	1789	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Nanaomycin_A selectively inhibits DNMT3B and reactivates silenced tumor suppressor genes in human cancer cells .
22290321	0	Nandrolone	0,10	MMP-2	20,25	Nandrolone	MMP-2	MESH:D009277	81686(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Nandrolone inhibits MMP-2 in the left ventricle of rats .
20563927	0	Nandrolone	0,10	MyoD	22,26	Nandrolone	MyoD	MESH:D009277	17927(Tax:10090)	Chemical	Gene	stimulates|amod|START_ENTITY END_ENTITY|nsubj|stimulates	Nandrolone stimulates MyoD expression during muscle regeneration in the condition of myonecrosis induced by Bothrops jararacussu venom_poisoning .
20043618	0	Nandrolone_decanoate	0,20	erythropoietin	42,56	Nandrolone decanoate	erythropoietin	MESH:C003297	2056	Chemical	Gene	START_ENTITY|nmod|treatment treatment|nmod|END_ENTITY	Nandrolone_decanoate for the treatment of erythropoietin refractory anemia : a case series .
26897372	0	Nanodiamond	26,37	NF-kB	102,107	Nanodiamond	NF-kB	MESH:D058612	81736(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|Role Role|nmod|END_ENTITY	Neuroprotective Effect of Nanodiamond in Alzheimer 's _ Disease Rat Model : a Pivotal Role for Modulating NF-kB and STAT3 Signaling .
20583856	0	Nantenine	0,9	acetylcholinesterase	16,36	Nantenine	acetylcholinesterase	MESH:C041615	43	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|amod|END_ENTITY	Nantenine as an acetylcholinesterase inhibitor : SAR , enzyme kinetics and molecular modeling investigations .
26840748	0	Naphthalene	0,11	microsomal_epoxide_hydrolase	28,56	Naphthalene	microsomal epoxide hydrolase	MESH:C031721	13849(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Naphthalene cytotoxicity in microsomal_epoxide_hydrolase deficient mice .
2160187	0	Naphthalenes	0,12	myeloperoxidase	30,45	Naphthalenes	myeloperoxidase	MESH:D009281	4353	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Naphthalenes as inhibitors of myeloperoxidase : direct and indirect mechanisms of inhibition .
18324761	0	Naphthamides	0,12	vascular_endothelial_growth_factor	33,67	Naphthamides	vascular endothelial growth factor	null	7422	Chemical	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	Naphthamides as novel and potent vascular_endothelial_growth_factor receptor tyrosine kinase inhibitors : design , synthesis , and evaluation .
21531136	0	Naphthol	0,8	TRPV1	24,29	Naphthol	TRPV1	CHEBI:35682	83810(Tax:10116)	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Naphthol derivatives as TRPV1 inhibitors for the treatment of urinary_incontinence .
12668002	0	Naphthyridines	27,41	spleen_tyrosine_kinase	66,88	Naphthyridines	spleen tyrosine kinase	MESH:D009287	6850	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Discovery and SAR of novel Naphthyridines as potent inhibitors of spleen_tyrosine_kinase -LRB- SYK -RRB- .
18930780	0	Naringenin	0,10	Akt	55,58	Naringenin	Akt	MESH:C005273	207	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|downregulation downregulation|nmod|END_ENTITY	Naringenin induces apoptosis through downregulation of Akt and caspase-3 activation in human leukemia THP-1 cells .
25372667	0	Naringenin	116,126	CYP1A1	27,33	Naringenin	CYP1A1	MESH:C005273	1543	Chemical	Gene	Hesperidin|appos|START_ENTITY Liver|nmod|Hesperidin Mechanism|nmod|Liver Mechanism|nmod|Activities Activities|compound|END_ENTITY	Mechanism of Inhibition of CYP1A1 and Glutathione_S-Transferase Activities in Fish Liver by Quercetin , Resveratrol , Naringenin , Hesperidin , and Rutin .
26157550	0	Naringenin	29,39	Cyclin_D1	80,89	Naringenin	Cyclin D1	MESH:C005273	595	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Anti-Proliferative Effect of Naringenin through p38-Dependent Downregulation of Cyclin_D1 in Human Colorectal_Cancer_Cells .
14739537	0	Naringenin	0,10	acetylcholinesterase	57,77	Naringenin	acetylcholinesterase	MESH:C005273	11423(Tax:10090)	Chemical	Gene	has|nsubj|START_ENTITY has|dobj|effect effect|nmod|END_ENTITY	Naringenin from Citrus junos has an inhibitory effect on acetylcholinesterase and a mitigating effect on amnesia .
24741397	0	Naringenin	0,10	cholecystokinin	22,37	Naringenin	cholecystokinin	MESH:C005273	885	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|compound|END_ENTITY	Naringenin stimulates cholecystokinin secretion in STC-1 cells .
25464380	0	Naringenin	103,113	p38	78,81	Naringenin	p38	MESH:C005273	26416(Tax:10090)	Chemical	Gene	Pathway|nmod|START_ENTITY Pathway|compound|END_ENTITY	The Inhibition of RANKL-Induced Osteoclastogenesis through the Suppression of p38 Signaling Pathway by Naringenin and Attenuation of Titanium-Particle-Induced Osteolysis .
12745063	0	Naringenin	0,10	phosphoinositide_3-kinase	20,45	Naringenin	phosphoinositide 3-kinase	MESH:C005273	5293	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Naringenin inhibits phosphoinositide_3-kinase activity and glucose uptake in 3T3-L1 adipocytes .
23478434	0	Naringin	0,8	CaMKII	18,24	Naringin	CaMKII	MESH:C005274	12323(Tax:10090)	Chemical	Gene	Activity|compound|START_ENTITY Activity|compound|END_ENTITY	Naringin Enhances CaMKII Activity and Improves Long-Term Memory in a Mouse Model of Alzheimer 's _ Disease .
22766066	0	Naringin	0,8	MUC5AC	32,38	Naringin	MUC5AC	MESH:C005274	4586	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|secretion secretion|compound|END_ENTITY	Naringin attenuates EGF-induced MUC5AC secretion in A549 cells by suppressing the cooperative activities of MAPKs-AP-1 and IKKs-IkB-NF-kB signaling pathways .
23694763	0	Naringin	0,8	b-catenin	93,102	Naringin	b-catenin	MESH:C005274	1499	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	Naringin inhibits growth potential of human triple-negative breast_cancer cells by targeting b-catenin signaling pathway .
19810018	0	Naringin	0,8	matrix_metalloproteinase-9	18,44	Naringin	matrix metalloproteinase-9	MESH:C005274	4318	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Naringin inhibits matrix_metalloproteinase-9 expression and AKT phosphorylation in tumor_necrosis_factor-alpha-induced vascular smooth muscle cells .
17301733	0	Naringin	0,8	organic_anion-transporting_polypeptide_1A2	56,98	Naringin	organic anion-transporting polypeptide 1A2	MESH:C005274	6579	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Naringin is a major and selective clinical inhibitor of organic_anion-transporting_polypeptide_1A2 -LRB- OATP1A2 -RRB- in grapefruit juice .
21532155	0	Nateglinide	0,11	glucagon-like_peptide-1	23,46	Nateglinide	glucagon-like peptide-1	MESH:C060142	2641	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|amod|END_ENTITY	Nateglinide stimulates glucagon-like_peptide-1 release by human intestinal L cells via a K -LRB- ATP -RRB- channel-independent mechanism .
12453951	0	Nateglinide	0,11	insulin	27,34	Nateglinide	insulin	MESH:C060142	3630	Chemical	Gene	improves|nsubj|START_ENTITY improves|dobj|secretion secretion|compound|END_ENTITY	Nateglinide improves early insulin secretion and controls postprandial glucose excursions in a prediabetic population .
21376417	0	Nateglinide	0,11	insulin	96,103	Nateglinide	insulin	MESH:C060142	3630	Chemical	Gene	START_ENTITY|advcl|optimizing optimizing|nmod|glargine glargine|compound|END_ENTITY	Nateglinide and acarbose for postprandial glucose control after optimizing fasting glucose with insulin glargine in patients with type 2 diabetes .
19700659	0	Naveglitazar	65,77	PPAR_alpha	96,106	Naveglitazar	PPAR alpha	MESH:C517861	25747(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Neoplastic and non-neoplastic changes in F-344 rats treated with Naveglitazar , a gamma-dominant PPAR_alpha / gamma agonist .
22905667	0	Nd	83,85	FGF9	34,38	Nd	FGF9	null	14180(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Histometric changes and epidermal FGF9 expression in carbon_photoenhancer-assisted Nd : YAG laser treatment .
12219997	0	Nd	93,95	IL-1beta	41,49	Nd	IL-1beta	null	100008990(Tax:9986)	Chemical	Gene	levels|nmod|START_ENTITY levels|amod|END_ENTITY	Effects of L-NAME and timolol on aqueous IL-1beta , IL-6 , IL-8 , TNF-alpha and NO levels after Nd : YAG laser iridotomy in rabbits .
22895019	0	Nebivolol	0,9	angiotensin_II	26,40	Nebivolol	angiotensin II	MESH:C052753	24179(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	Nebivolol reduces cardiac angiotensin_II , associated oxidative stress and fibrosis but not arterial pressure in salt-loaded spontaneously hypertensive rats .
24810904	0	Necrostatin-1	0,13	IL-17	35,40	Necrostatin-1	IL-17	MESH:C507699	16171(Tax:10090)	Chemical	Gene	pathway|dep|START_ENTITY pathway|compound|END_ENTITY	Necrostatin-1 inhibits Hmgb1-IL-23 / IL-17 pathway and attenuates cardiac_ischemia reperfusion injury .
19457128	0	Nefiracetam	0,11	CaM_kinase_II	26,39	Nefiracetam	CaM kinase II	MESH:C058876	12325(Tax:10090)	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Nefiracetam activation of CaM_kinase_II and protein kinase C mediated by NMDA and metabotropic glutamate receptors in olfactory bulbectomized mice .
17302375	0	Nelfinavir	0,10	insulin	29,36	Nelfinavir	insulin	MESH:D019888	3630	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|resistance resistance|compound|END_ENTITY	Nelfinavir induces adipocyte insulin resistance through the induction of oxidative stress : differential protective effect of antioxidant agents .
22540830	0	Nelfinavir	0,10	sterol_regulatory_element_binding_protein-1	59,102	Nelfinavir	sterol regulatory element binding protein-1	MESH:D019888	6720	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|proteolysis proteolysis|nmod|END_ENTITY	Nelfinavir inhibits regulated intramembrane proteolysis of sterol_regulatory_element_binding_protein-1 and activating_transcription_factor_6 in castration-resistant prostate_cancer .
25575821	0	Neoalbaconol	0,12	TNFa	91,95	Neoalbaconol	TNFa	null	7124	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|regulating regulating|dobj|END_ENTITY	Neoalbaconol induces cell death through necroptosis by regulating RIPK-dependent autocrine TNFa and ROS production .
12135616	0	Neocarzinostatin	0,16	Mre11	25,30	Neocarzinostatin	Mre11	MESH:D009353	4361	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|amod|END_ENTITY	Neocarzinostatin induces Mre11 phosphorylation and focus formation through an ATM - and NBS1-dependent mechanism .
25679052	0	Neochamaejasmin_B	22,39	P-Glycoprotein	43,57	Neochamaejasmin B	P-Glycoprotein	null	610926(Tax:9615)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Inhibitory Effects of Neochamaejasmin_B on P-Glycoprotein in MDCK-hMDR1 Cells and Molecular Docking of NCB Binding in P-Glycoprotein .
26721439	5	Neogenin	605,613	RGMa	618,622	Neogenin	RGMa	null	56963	Chemical	Gene	START_ENTITY|appos|receptor receptor|compound|END_ENTITY	Neogenin , an RGMa receptor , in HUAEC is required for the effect of RGMa .
21249263	0	Neoglycopeptides	18,34	MUC1	13,17	Neoglycopeptides	MUC1	null	4582	Chemical	Gene	START_ENTITY|nsubj|Synthesis Synthesis|nmod|END_ENTITY	Synthesis of MUC1 Neoglycopeptides using efficient microwave-enhanced chaotrope-assisted click chemistry .
19214385	0	Neolignans	0,10	cyclooxygenase_2	53,69	Neolignans	cyclooxygenase 2	MESH:D017705	19225(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Neolignans from North American Magnolia species with cyclooxygenase_2 inhibitory activity .
2198827	0	Neonate	0,7	IgE	14,17	Neonate	IgE	null	3497	Chemical	Gene	START_ENTITY|dobj|levels levels|compound|END_ENTITY	Neonate blood IgE levels on filter paper as indicators of atopic_disease .
26464060	0	Neonicotinoids	11,25	CYP19	85,90	Neonicotinoids	CYP19	null	1588	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of Neonicotinoids on Promoter-Specific Expression and Activity of Aromatase -LRB- CYP19 -RRB- in Human Adrenocortical_Carcinoma -LRB- H295R -RRB- and Primary Umbilical Vein Endothelial -LRB- HUVEC -RRB- Cells .
23564066	0	Neopterin	0,9	ABCA1	45,50	Neopterin	ABCA1	MESH:D019798	19	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Neopterin negatively regulates expression of ABCA1 and ABCG1 by the LXRa signaling pathway in THP-1 macrophage-derived foam cells .
27031691	0	Neopterin	0,9	CD14	22,26	Neopterin	CD14	MESH:D019798	929	Chemical	Gene	Levels|compound|START_ENTITY Levels|compound|END_ENTITY	Neopterin and Soluble CD14 Levels as Indicators of Immune Activation in Cases with Indeterminate Pattern and True Positive_HIV-1_Infection .
23564066	0	Neopterin	0,9	LXRa	68,72	Neopterin	LXRa	MESH:D019798	10062	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Neopterin negatively regulates expression of ABCA1 and ABCG1 by the LXRa signaling pathway in THP-1 macrophage-derived foam cells .
2110500	0	Neopterin	0,9	THP-1	84,89	Neopterin	THP-1	MESH:D019798	2736	Chemical	Gene	formation|amod|START_ENTITY formation|appos|END_ENTITY	Neopterin formation and tryptophan degradation by a human myelomonocytic cell line -LRB- THP-1 -RRB- upon cytokine treatment .
23564066	0	Neopterin	0,9	THP-1	94,99	Neopterin	THP-1	MESH:D019798	2736	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|LXRa LXRa|acl|signaling signaling|nmod|cells cells|compound|END_ENTITY	Neopterin negatively regulates expression of ABCA1 and ABCG1 by the LXRa signaling pathway in THP-1 macrophage-derived foam cells .
1563242	1	Neopterin	83,92	interleukin-2	105,118	Neopterin	interleukin-2	MESH:D019798	3558	Chemical	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Neopterin and soluble interleukin-2 receptor .
16134219	0	Neopterin	0,9	interleukin-2	66,79	Neopterin	interleukin-2	MESH:D019798	3558	Chemical	Gene	START_ENTITY|nmod|renal_cell_carcinoma renal_cell_carcinoma|dep|administration administration|nmod|END_ENTITY	Neopterin in renal_cell_carcinoma : inhalational administration of interleukin-2 is not accompanied by a rise of urinary neopterin .
8706912	0	Neopterin	0,9	nuclear_factor-kappa_B	41,63	Neopterin	nuclear factor-kappa B	MESH:D019798	4790	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Neopterin activates transcription factor nuclear_factor-kappa_B in vascular smooth muscle cells .
11493697	0	Nephrocystin	0,12	Pyk2	28,32	Nephrocystin	Pyk2	null	2185	Chemical	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Nephrocystin interacts with Pyk2 , p130 -LRB- Cas -RRB- , and tensin and triggers phosphorylation of Pyk2 .
20142587	0	Neratinib	0,9	ErbB	27,31	Neratinib	ErbB	MESH:C487932	1956	Chemical	Gene	tyrosine|advmod|START_ENTITY tyrosine|nsubj|receptor receptor|compound|END_ENTITY	Neratinib , an irreversible ErbB receptor tyrosine kinase inhibitor , in patients with advanced ErbB2-positive breast_cancer .
20427288	5	Net	896,899	PHD2	926,930	Net	PHD2	null	54583	Chemical	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Net physically interacts with PHD2 in hypoxia , whereas PHD1 and PHD3 bind to Net in normoxia and hypoxia .
24098507	0	Netazepide	0,10	gastrin_receptor	14,30	Netazepide	gastrin receptor	null	887	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Netazepide , a gastrin_receptor antagonist , normalises tumour biomarkers and causes regression of type 1 gastric_neuroendocrine_tumours in a nonrandomised trial of patients with chronic atrophic_gastritis .
11892904	0	Netilmicin	0,10	retinol_binding_protein	29,52	Netilmicin	retinol binding protein	MESH:D009428	5950	Chemical	Gene	effect|compound|START_ENTITY effect|nmod|END_ENTITY	Netilmicin effect on urinary retinol_binding_protein -LRB- RBP -RRB- and N-acetyl-beta-D-glucosaminidase -LRB- NAG -RRB- in preterm newborns with and without anoxia .
2176488	0	Neurokinin_A	0,12	c-fos	21,26	Neurokinin A	c-fos	MESH:D015288	314322(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Neurokinin_A induces c-fos , c-jun , and c-myc expression in L6 rat myoblasts .
2176599	0	Neurokinin_A	0,12	c-fos	39,44	Neurokinin A	c-fos	MESH:D015288	314322(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Neurokinin_A induces expression of the c-fos , c-jun , and c-myc genes in rat smooth muscle cells .
26561648	0	Neuronostatin	0,13	GPR107	23,29	Neuronostatin	GPR107	null	57720	Chemical	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	Neuronostatin acts via GPR107 to increase cAMP-independent PKA phosphorylation and proglucagon mRNA accumulation in pancreatic alpha cells .
1334775	0	Neuropeptide_Y	0,14	alpha-MSH	24,33	Neuropeptide Y	alpha-MSH	MESH:D009478	24664(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|amod|END_ENTITY	Neuropeptide_Y inhibits alpha-MSH release from rat hypothalamic slices through a pertussis toxin-sensitive G protein .
21059219	0	Neutrophil_unsaturated_fatty_acid	0,33	GM-CSF	45,51	Neutrophil unsaturated fatty acid	GM-CSF	null	1437	Chemical	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	Neutrophil_unsaturated_fatty_acid release by GM-CSF is impaired in cystic_fibrosis .
26620700	0	Nevirapine	0,10	paraoxonase-1	25,38	Nevirapine	paraoxonase-1	MESH:D019829	84024(Tax:10116)	Chemical	Gene	modulation|amod|START_ENTITY modulation|nmod|END_ENTITY	Nevirapine modulation of paraoxonase-1 in the liver : An in vitro three-model approach .
25653379	2	Nfasc	251,256	Neurofascin	238,249	Nfasc	neurofascin	null	23114	Chemical	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	The Neurofascin -LRB- Nfasc -RRB- gene has a unique role in node formation because it encodes glial and neuronal isoforms of neurofascin -LRB- Nfasc155 and Nfasc186 , respectively -RRB- with key functions in assembling the nodal macromolecular complex .
3777181	7	Ni	1135,1137	GTP	1079,1082	Ni	PTH	null	5741	Chemical	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	We conclude that GTP inhibits PTH action in opossum kidney cells through Ni but that PTH-induced desensitization is not mediated by Ni .
20867044	0	Ni2	46,49	d9/d8	52,57	Ni2	d9/d8	CHEBI:49786	201254	Chemical	Gene	_|compound|START_ENTITY _|appos|END_ENTITY	Bulk magnetic order in a two-dimensional Ni1 + / Ni2 + -LRB- d9/d8 -RRB- _ nickelate , isoelectronic with superconducting cuprates .
26027655	0	NiCo2O4	74,81	CO2	39,42	NiCo2O4	CO2	null	717	Chemical	Gene	reduction|nmod|START_ENTITY reduction|nmod|END_ENTITY	Reinforced photocatalytic reduction of CO2 to CO by a ternary metal_oxide NiCo2O4 .
19113375	0	NiGa2S4	66,73	Spin	0,4	NiGa2S4	Spin	null	10927	Chemical	Gene	effects|nmod|START_ENTITY effects|amod|END_ENTITY	Spin dependent impurity effects on the 2D frustrated magnetism of NiGa2S4 .
22969777	0	Niacin	95,101	Adiponectin	39,50	Niacin	Adiponectin	MESH:D009525	9370	Chemical	Gene	Therapy|compound|START_ENTITY Relationship|nmod|Therapy Relationship|nmod|Changes Changes|nmod|Concentration Concentration|compound|END_ENTITY	Relationship between Changes in Plasma Adiponectin Concentration and Insulin Sensitivity after Niacin Therapy .
22750059	0	Niacin	0,6	CETP	22,26	Niacin	CETP	MESH:D009525	1071	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|levels levels|compound|END_ENTITY	Niacin reduces plasma CETP levels by diminishing liver macrophage content in CETP transgenic_mice .
19141678	0	Niacin	0,6	GPR109A	52,59	Niacin	GPR109A	MESH:D009525	80885(Tax:10090)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|receptor receptor|compound|END_ENTITY	Niacin stimulates adiponectin secretion through the GPR109A receptor .
24662263	0	Niacin	0,6	G_protein_estrogen_receptor	21,48	Niacin	G protein estrogen receptor	MESH:D009525	2852	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Niacin activates the G_protein_estrogen_receptor -LRB- GPER -RRB- - mediated signalling .
16386710	0	Niacin	0,6	PPARgamma	15,24	Niacin	PPARgamma	MESH:D009525	5468	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Niacin induces PPARgamma expression and transcriptional activation in macrophages via HM74 and HM74a-mediated induction of prostaglandin synthesis pathways .
19141678	0	Niacin	0,6	adiponectin	18,29	Niacin	adiponectin	MESH:D009525	9370	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|compound|END_ENTITY	Niacin stimulates adiponectin secretion through the GPR109A receptor .
24956528	0	Niacin	0,6	myeloperoxidase	27,42	Niacin	myeloperoxidase	MESH:D009525	4353	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|END_ENTITY	Niacin decreases leukocyte myeloperoxidase : mechanistic role of redox agents and Src/p38MAP _ kinase .
9147187	0	Nicardipine	0,11	endothelin-1	28,40	Nicardipine	endothelin-1	MESH:D009529	100009270(Tax:9986)	Chemical	Gene	modification|amod|START_ENTITY modification|nmod|effects effects|amod|END_ENTITY	Nicardipine modification of endothelin-1 effects on visual evoked potential .
2169937	0	Nicergoline	0,11	Ca2	28,31	Nicergoline	Ca2	MESH:D009530	54231(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|channels channels|amod|END_ENTITY	Nicergoline inhibits T-type Ca2 + channels in rat isolated hippocampal CA1 pyramidal neurones .
20029189	0	Nicergoline	0,11	substance_P	28,39	Nicergoline	substance P	MESH:D009530	6863	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|compound|END_ENTITY	Nicergoline increases serum substance_P levels in patients with an ischaemic_stroke .
21694649	0	Nicergoline	0,11	substance_P	47,58	Nicergoline	substance P	MESH:D009530	6863	Chemical	Gene	improves|nsubj|START_ENTITY improves|advcl|upregulating upregulating|dobj|END_ENTITY	Nicergoline improves dysphagia by upregulating substance_P in the elderly .
15304089	0	Nickel	0,6	CCR7	23,27	Nickel	CCR7	MESH:D009532	1236	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Nickel and DNCB induce CCR7 expression on human dendritic cells through different signalling pathways : role of TNF-alpha and MAPK .
18482439	0	Nickel	0,6	IFN-gamma	38,47	Nickel	IFN-gamma	MESH:D009532	3458	Chemical	Gene	START_ENTITY|acl|induced induced|dobj|production production|amod|END_ENTITY	Nickel , palladium and rhodium induced IFN-gamma and IL-10 production as assessed by in vitro ELISpot-analysis in contact dermatitis patients .
24320827	0	Nickel	0,6	RNase_a	25,32	Nickel	RNase a	MESH:D009532	282340(Tax:9913)	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|END_ENTITY	Nickel affects xylem Sap RNase_a and converts RNase_A to a urease .
26116531	0	Niclosamide	0,11	Tax	83,86	Niclosamide	Tax	MESH:D009534	1491938(Tax:11908)	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	Niclosamide , an anti-helminthic molecule , downregulates the retroviral oncoprotein Tax and pro-survival Bcl-2 proteins in HTLV-1-transformed T lymphocytes .
24740322	0	Niclosamide	0,11	androgen_receptor	21,38	Niclosamide	androgen receptor	MESH:D009534	367	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Niclosamide inhibits androgen_receptor variants expression and overcomes enzalutamide resistance in castration-resistant_prostate_cancer .
27049719	0	Niclosamide	0,11	androgen_receptor	61,78	Niclosamide	androgen receptor	MESH:D009534	367	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|treatment treatment|nmod|inhibition inhibition|nmod|variants variants|compound|END_ENTITY	Niclosamide enhances abiraterone treatment via inhibition of androgen_receptor variants in castration resistant prostate_cancer .
27050899	0	Nicorandil	0,10	Interleukin-8	42,55	Nicorandil	Interleukin-8	MESH:D020108	3576	Chemical	Gene	START_ENTITY|dobj|Expression Expression|compound|END_ENTITY	Nicorandil Inhibits Cyclic Strain-Induced Interleukin-8 Expression in Human Umbilical Vein Endothelial Cells .
16044078	0	Nicorandil	0,10	NF-kappaB	22,31	Nicorandil	NF-kappaB	MESH:D020108	4790	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|activation activation|amod|END_ENTITY	Nicorandil attenuates NF-kappaB activation , adhesion molecule expression , and cytokine production in patients with coronary artery bypass surgery .
14555283	0	Nicorandil	0,10	TNFalpha	35,43	Nicorandil	TNFalpha	MESH:D020108	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|nmod|END_ENTITY	Nicorandil inhibits the release of TNFalpha from a lymphocyte cell line and peripheral blood lymphocytes .
24676284	0	Nicorandil	0,10	VCAM-1	34,40	Nicorandil	VCAM-1	MESH:D020108	25361(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|compound|END_ENTITY	Nicorandil attenuates endothelial VCAM-1 expression via thioredoxin production in diabetic rats induced by streptozotocin .
11483869	0	Nicorandil	0,10	endothelial_nitric_oxide_synthase	28,61	Nicorandil	endothelial nitric oxide synthase	MESH:D020108	24600(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	Nicorandil enhances cardiac endothelial_nitric_oxide_synthase expression via activation of adenosine_triphosphate-sensitive K channel in rat .
16775500	0	Nicorandil	0,10	endothelial_nitric_oxide_synthase	36,69	Nicorandil	endothelial nitric oxide synthase	MESH:D020108	24600(Tax:10116)	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Nicorandil but not ISDN upregulates endothelial_nitric_oxide_synthase expression , preventing left_ventricular_remodeling and degradation of cardiac function in Dahl salt-sensitive hypertensive rats with congestive_heart_failure .
21645504	0	Nicorandil	0,10	endothelin-1	44,56	Nicorandil	endothelin-1	MESH:D020108	1906	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|amod|END_ENTITY	Nicorandil attenuates cyclic strain-induced endothelin-1 expression via the induction of activating_transcription_factor_3 in human umbilical vein endothelial cells .
26442863	0	Nicotinamide	10,22	CD8	90,93	Nicotinamide	CD8	MESH:D009536	925	Chemical	Gene	Generation|compound|START_ENTITY Generation|nmod|END_ENTITY	High-Dose Nicotinamide Suppresses ROS Generation and Augments Population Expansion during CD8 -LRB- + -RRB- T Cell Activation .
12069599	0	Nicotinamide	0,12	GLUT1	71,76	Nicotinamide	GLUT1	MESH:D009536	6513	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Nicotinamide is not a substrate of the facilitative hexose transporter GLUT1 .
19288225	0	Nicotinamide	0,12	SIRT1	124,129	Nicotinamide	SIRT1	MESH:D009536	93759(Tax:10090)	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|parataxis|endanger endanger|nsubj|consumption consumption|nmod|END_ENTITY	Nicotinamide prevents NAD + depletion and protects neurons against excitotoxicity and cerebral_ischemia : NAD + consumption by SIRT1 may endanger energetically compromised neurons .
22198152	0	Nicotinamide	0,12	SIRT1	16,21	Nicotinamide	SIRT1	MESH:D009536	23411	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Nicotinamide , a SIRT1 inhibitor , inhibits differentiation and facilitates expansion of hematopoietic progenitor cells with enhanced bone marrow homing and engraftment .
23561972	0	Nicotinamide	0,12	SIRT1	115,120	Nicotinamide	SIRT1	MESH:D009536	23411	Chemical	Gene	prohibits|nsubj|START_ENTITY prohibits|advcl|deregulating deregulating|dobj|pathways pathways|compound|END_ENTITY	Nicotinamide prohibits proliferation and enhances chemosensitivity of pancreatic_cancer cells through deregulating SIRT1 and Ras/Akt pathways .
25470550	0	Nicotinamide	44,56	SIRT3	14,19	Nicotinamide	SIRT3	MESH:D009536	64384(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Activation Activation|nmod|END_ENTITY	Activation of SIRT3 by the NAD -LRB- + -RRB- Precursor Nicotinamide Riboside Protects from Noise-Induced Hearing_Loss .
26352206	0	Nicotinamide	0,12	Sirt1	104,109	Nicotinamide	Sirt1	MESH:D009536	23411	Chemical	Gene	ameliorates|nsubj|START_ENTITY ameliorates|nmod|hepatocytes hepatocytes|nmod|upregulation upregulation|amod|END_ENTITY	Nicotinamide ameliorates palmitate-induced ER stress in hepatocytes via cAMP/PKA/CREB pathway-dependent Sirt1 upregulation .
24184296	0	Nicotinamide	0,12	glucose-6-phosphate_dehydrogenase	16,49	Nicotinamide	glucose-6-phosphate dehydrogenase	MESH:D009536	14380(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Nicotinamide , a glucose-6-phosphate_dehydrogenase non-competitive mixed inhibitor , modifies redox balance and lipid accumulation in 3T3-L1 cells .
23397947	0	Nicotinamide	0,12	monocyte_chemoattractant_protein-1	77,111	Nicotinamide	monocyte chemoattractant protein-1	MESH:D009536	6347	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|nmod|END_ENTITY	Nicotinamide downregulates gene expression of interleukin-6 , interleukin-10 , monocyte_chemoattractant_protein-1 , and tumour_necrosis_factor-a gene expression in HaCaT keratinocytes after ultraviolet B irradiation .
20367952	0	Nicotinamide-adenine_dinucleotide_phosphate	1,44	p22phox	53,60	Nicotinamide-adenine dinucleotide phosphate	p22phox	MESH:D009249	1535	Chemical	Gene	oxidase|nsubj|START_ENTITY oxidase|dobj|expression expression|amod|END_ENTITY	-LSB- Nicotinamide-adenine_dinucleotide_phosphate oxidase p22phox expression in induced sputum cells for patients with obstructive_sleep_apnea_hypopnea_syndrome -RSB- .
26045998	0	Nicotinamide_adenine_dinucleotide	0,33	DNA_methyltransferase_1	51,74	Nicotinamide adenine dinucleotide	DNA methyltransferase 1	MESH:D009243	1786	Chemical	Gene	affect|nsubj|START_ENTITY affect|dobj|END_ENTITY	Nicotinamide_adenine_dinucleotide -LRB- NAD -RRB- may affect DNA_methyltransferase_1 through regulation of BRCA1 in ovarian_cancer .
6260474	0	Nicotinamide_adenine_dinucleotide	0,33	parathyroid_hormone	56,75	Nicotinamide adenine dinucleotide	parathyroid hormone	MESH:D009243	24694(Tax:10116)	Chemical	Gene	response|amod|START_ENTITY response|nmod|END_ENTITY	Nicotinamide_adenine_dinucleotide and renal response to parathyroid_hormone .
22898831	0	Nicotine	0,8	4-1BBL	22,28	Nicotine	4-1BBL	MESH:D009538	8744	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Nicotine up-regulated 4-1BBL expression by activating Mek-PI3K pathway augments the efficacy of bone marrow-derived dendritic cell vaccination .
22315316	0	Nicotine	0,8	AMP-activated_protein_kinase	62,90	Nicotine	AMP-activated protein kinase	MESH:D009538	5563	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Nicotine induces negative energy balance through hypothalamic AMP-activated_protein_kinase .
19654299	0	Nicotine	0,8	AP-2alpha	127,136	Nicotine	AP-2alpha	MESH:D009538	7020	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|activation activation|nmod|END_ENTITY	Nicotine stimulates PPARbeta/delta expression in human lung_carcinoma cells through activation of PI3K/mTOR and suppression of AP-2alpha .
12611941	0	Nicotine	0,8	A_beta	44,50	Nicotine	A beta	MESH:D009538	54226(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|actions actions|nmod|END_ENTITY	Nicotine enhances the depressive actions of A_beta 1-40 on long-term potentiation in the rat hippocampal CA1 region in vivo .
15147304	0	Nicotine	0,8	A_beta	17,23	Nicotine	A beta	MESH:D009538	11820(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	Nicotine reduces A_beta in the brain and cerebral vessels of APPsw mice .
15037618	0	Nicotine	0,8	Bad	47,50	Nicotine	Bad	MESH:D009538	572	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Nicotine induces multi-site phosphorylation of Bad in association with suppression of apoptosis .
23149874	0	Nicotine	0,8	C-reactive_protein	35,53	Nicotine	C-reactive protein	MESH:D009538	1401	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Nicotine induces the expression of C-reactive_protein via MAPK-dependent signal pathway in U937 macrophages .
17017527	0	Nicotine	0,8	CYP	23,26	Nicotine	CYP	MESH:D009538	9360	Chemical	Gene	enzymes|compound|START_ENTITY enzymes|compound|END_ENTITY	Nicotine induces brain CYP enzymes : relevance to Parkinson 's _ disease .
15861035	0	Nicotine	0,8	CYP2A6	35,41	Nicotine	CYP2A6	MESH:D009538	1548	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|dep|impact impact|nmod|END_ENTITY	Nicotine metabolism : the impact of CYP2A6 on estimates of additive genetic influence .
26060595	0	Nicotine	65,73	CYP2A6	0,6	Nicotine	CYP2A6	MESH:D009538	1548	Chemical	Gene	Dependence|compound|START_ENTITY Treatment|nmod|Dependence Treatment|compound|END_ENTITY	CYP2A6 Polymorphisms May Strengthen Individualized Treatment for Nicotine Dependence .
26851241	0	Nicotine	131,139	CYP2A6	16,22	Nicotine	CYP2A6	MESH:D009538	1548	Chemical	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of CYP2A6 by the Dietary Phenylpropanoid trans-Cinnamic Aldehyde -LRB- Cinnamaldehyde -RRB- and Estimation of Interactions with Nicotine and Letrozole .
16040813	0	Nicotine	0,8	DARPP-32	19,27	Nicotine	DARPP-32	MESH:D009538	84152	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Nicotine regulates DARPP-32 -LRB- dopamine - _ and_cAMP-regulated_phosphoprotein_of_32_kDa -RRB- phosphorylation at multiple sites in neostriatal neurons .
17333132	0	Nicotine	0,8	FosB	19,23	Nicotine	FosB	MESH:D009538	100360880	Chemical	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	Nicotine increases FosB expression within a subset of reward - and memory-related brain regions during both peri - and post-adolescence .
18477628	0	Nicotine	0,8	GRP78	85,90	Nicotine	GRP78	MESH:D009538	25617(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|nmod|END_ENTITY	Nicotine suppresses tunicamycin-induced , but not thapsigargin-induced , expression of GRP78 during ER stress-mediated apoptosis in PC12 cells .
15110924	0	Nicotine	0,8	GnRH	33,37	Nicotine	GnRH	MESH:D009538	25194(Tax:10116)	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|secretion secretion|amod|END_ENTITY	Nicotine inhibition of pulsatile GnRH secretion is mediated by GABAA receptor system in the cultured rat embryonic olfactory placode .
25059554	0	Nicotine	0,8	IL-1b	35,40	Nicotine	IL-1b	MESH:D009538	3553	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|nmod|END_ENTITY	Nicotine induces the production of IL-1b and IL-8 via the a7 nAChR/NF-kB pathway in human periodontal ligament cells : an in vitro study .
12960242	0	Nicotine	0,8	IL-8	46,50	Nicotine	IL-8	MESH:D009538	3576	Chemical	Gene	induces|nsubj|START_ENTITY induces|xcomp|produce produce|dobj|END_ENTITY	Nicotine induces human neutrophils to produce IL-8 through the generation of peroxynitrite and subsequent activation of NF-kappaB .
22119045	0	Nicotine	0,8	IL-8	22,26	Nicotine	IL-8	MESH:D009538	3576	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Nicotine up-regulates IL-8 expression in human gingival epithelial cells following stimulation with IL-1b or P. _ gingivalis lipopolysaccharide via nicotinic acetylcholine receptor signalling .
20923448	0	Nicotine	0,8	MMP-9	33,38	Nicotine	MMP-9	MESH:D009538	4318	Chemical	Gene	modulates|amod|START_ENTITY gelatinase|nsubj|modulates gelatinase|dobj|B B|appos|END_ENTITY	Nicotine modulates gelatinase B -LRB- MMP-9 -RRB- and epilysin -LRB- MMP-28 -RRB- expression in reconstituted human oral epithelium .
23125003	0	Nicotine	0,8	MMP-9	17,22	Nicotine	MMP-9	MESH:D009538	4318	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Nicotine reduced MMP-9 expression in the primary porcine tenocytes exposed to cyclic stretch .
22537161	0	Nicotine	0,8	MUC4	56,60	Nicotine	MUC4	MESH:D009538	4585	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Nicotine , IFN-y and retinoic_acid mediated induction of MUC4 in pancreatic_cancer requires E2F1 and STAT-1 transcription factors and utilize different signaling cascades .
17878927	0	Nicotine	0,8	NFkappaB	60,68	Nicotine	NFkappaB	MESH:D009538	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|cells cells|nmod|END_ENTITY	Nicotine inhibits cytokine production by placenta cells via NFkappaB : potential role in pregnancy-induced hypertension .
24830656	0	Nicotine	10,18	RANKL	22,27	Nicotine	RANKL	MESH:D009538	117516(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of Nicotine on RANKL and OPG and Bone Mineral Density .
26647419	0	Nicotine	0,8	Sord	17,21	Nicotine	Sord	MESH:D009538	20322(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|compound|END_ENTITY	Nicotine reduces Sord expression and tyrosine phosphorylation in capacitated sperm .
21691078	0	Nicotine	0,8	TNF-a	17,22	Nicotine	TNF-a	MESH:D009538	7124	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|amod|END_ENTITY	Nicotine reduces TNF-a expression through a a7 nAChR/MyD88/NF - B pathway in HBE16 airway epithelial cells .
11469915	0	Nicotine	0,8	TNF-alpha	29,38	Nicotine	TNF-alpha	MESH:D009538	7124	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Nicotine induces endothelial TNF-alpha expression , which mediates growth_retardation in vitro .
15454119	0	Nicotine	0,8	TNF-alpha	109,118	Nicotine	TNF-alpha	MESH:D009538	7124	Chemical	Gene	augment|nsubj|START_ENTITY augment|nmod|macrophages macrophages|acl|secreting secreting|dobj|END_ENTITY	Nicotine could augment adhesion molecule expression in human endothelial cells through macrophages secreting TNF-alpha , IL-1beta .
19749751	0	Nicotine	0,8	TRPA1	51,56	Nicotine	TRPA1	MESH:D009538	277328(Tax:10090)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Nicotine activates the chemosensory cation channel TRPA1 .
16601104	0	Nicotine	0,8	XIAP	79,83	Nicotine	XIAP	MESH:D009538	331	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|apoptosis apoptosis|acl|induced induced|nmod|END_ENTITY	Nicotine inhibits apoptosis induced by chemotherapeutic drugs by up-regulating XIAP and survivin .
16707114	0	Nicotine	0,8	amyloid_precursor_protein	33,58	Nicotine	amyloid precursor protein	MESH:D009538	11820(Tax:10090)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	Nicotine modulates expression of amyloid_precursor_protein and amyloid_precursor-like_protein_2 in mouse brain and in SH-SY5Y neuroblastoma cells .
21267696	0	Nicotine	0,8	beta_defensin-2	43,58	Nicotine	beta defensin-2	MESH:D009538	1673	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Nicotine induces upregulated expression of beta_defensin-2 via the p38MAPK pathway in the HaCaT human keratinocyte cell line .
19054295	0	Nicotine	0,8	bone_sialoprotein	20,37	Nicotine	bone sialoprotein	MESH:D009538	24477(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Nicotine suppresses bone_sialoprotein gene expression .
10555165	0	Nicotine	0,8	c-Fos	33,38	Nicotine	c-Fos	MESH:D009538	2353	Chemical	Gene	up-regulates|amod|START_ENTITY END_ENTITY|nsubj|up-regulates	Nicotine withdrawal up-regulates c-Fos transcription in pheochromocytoma cells .
19912923	0	Nicotine	60,68	c-Fos	37,42	Nicotine	c-Fos	MESH:D009538	314322(Tax:10116)	Chemical	Gene	Response|xcomp|START_ENTITY Response|nsubj|Induction Induction|nmod|mRNA mRNA|amod|END_ENTITY	Induction and Desensitization of the c-Fos mRNA Response to Nicotine in Rat Brain .
7913201	0	Nicotine	0,8	c-fos	17,22	Nicotine	c-fos	MESH:D009538	314322(Tax:10116)	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Nicotine induced c-fos expression in the striatum is mediated mostly by dopamine D1 receptor and is dependent on NMDA stimulation .
18835254	0	Nicotine	0,8	cyclin_D1	56,65	Nicotine	cyclin D1	MESH:D009538	12443(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|up-regulation up-regulation|amod|END_ENTITY	Nicotine induces cell proliferation in association with cyclin_D1 up-regulation and inhibits cell differentiation in association with p53 regulation in a murine pre-osteoblastic cell line .
18805435	0	Nicotine	0,8	cyclooxygenase-2	67,83	Nicotine	cyclooxygenase-2	MESH:D009538	5743	Chemical	Gene	START_ENTITY|dep|activity activity|amod|END_ENTITY	Nicotine and 4 - -LRB- methylnitrosamino -RRB- -1 - -LRB- 3-pyridyl -RRB- -1 - butanone induce cyclooxygenase-2 activity in human gastric_cancer cells : Involvement of nicotinic_acetylcholine_receptor -LRB- nAChR -RRB- and beta-adrenergic receptor signaling pathways .
19147120	0	Nicotine	0,8	cyclooxygenase-2	38,54	Nicotine	cyclooxygenase-2	MESH:D009538	5743	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|nmod|mRNA mRNA|amod|END_ENTITY	Nicotine stimulates the expression of cyclooxygenase-2 mRNA via NFkappaB activation in human gingival fibroblasts .
20079464	0	Nicotine	0,8	cyclooxygenase-2	17,33	Nicotine	cyclooxygenase-2	MESH:D009538	5743	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Nicotine induces cyclooxygenase-2 and prostaglandin_E -LRB- 2 -RRB- expression in human umbilical vein endothelial cells .
16317086	0	Nicotine	0,8	cyclooxygenase-2_and_vascular_endothelial_growth_factor_receptor-2	17,83	Nicotine	cyclooxygenase-2 and vascular endothelial growth factor receptor-2	MESH:D009538	5743	Chemical	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Nicotine induces cyclooxygenase-2_and_vascular_endothelial_growth_factor_receptor-2 in association with tumor-associated invasion and angiogenesis in gastric_cancer .
7913213	0	Nicotine	0,8	diazepam_binding_inhibitor	19,45	Nicotine	diazepam binding inhibitor	MESH:D009538	1622	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|mRNA mRNA|amod|END_ENTITY	Nicotine increases diazepam_binding_inhibitor -LRB- DBI -RRB- mRNA in primary cultured neurons .
20074615	0	Nicotine	0,8	dopamine_transporter	58,78	Nicotine	dopamine transporter	MESH:D009538	6531	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|nmod|gene gene|compound|END_ENTITY	Nicotine stimulates transcriptional activity of the human dopamine_transporter gene .
21159320	0	Nicotine	0,8	dynamin_1	33,42	Nicotine	dynamin 1	MESH:D009538	140694(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	Nicotine modulates expression of dynamin_1 in rat brain and SH-SY5Y cells .
22490492	0	Nicotine	0,8	glucocorticoid_receptor	91,114	Nicotine	glucocorticoid receptor	MESH:D009538	2908	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	Nicotine inhibits histone_deacetylase_6 activity and chaperone-dependent activation of the glucocorticoid_receptor in A549 cells .
6508989	0	Nicotine	0,8	growth_hormone	77,91	Nicotine	growth hormone	MESH:D009538	2688	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|increase increase|nmod|concentrations concentrations|compound|END_ENTITY	Nicotine from cigarette smoking enhances clonidine-induced increase of serum growth_hormone concentrations in men .
22490492	0	Nicotine	0,8	histone_deacetylase_6	18,39	Nicotine	histone deacetylase 6	MESH:D009538	10013	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Nicotine inhibits histone_deacetylase_6 activity and chaperone-dependent activation of the glucocorticoid_receptor in A549 cells .
17699846	0	Nicotine	0,8	hypoxia-inducible_factor-1alpha	17,48	Nicotine	hypoxia-inducible factor-1alpha	MESH:D009538	3091	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Nicotine induces hypoxia-inducible_factor-1alpha expression in human lung_cancer cells via nicotinic acetylcholine receptor-mediated signaling pathways .
18855939	0	Nicotine	0,8	iNOS	20,24	Nicotine	iNOS	MESH:D009538	24599(Tax:10116)	Chemical	Gene	attenuates|amod|START_ENTITY END_ENTITY|nsubj|attenuates	Nicotine attenuates iNOS expression and contributes to neuroprotection in a compressive model of spinal_cord_injury .
23308043	0	Nicotine	0,8	inhibitor_of_differentiation-1	17,47	Nicotine	inhibitor of differentiation-1	MESH:D009538	3397	Chemical	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Nicotine induces inhibitor_of_differentiation-1 in a Src-dependent pathway promoting metastasis and chemoresistance in pancreatic adenocarcinoma .
11422660	0	Nicotine	0,8	insulin	34,41	Nicotine	insulin	MESH:D009538	3630	Chemical	Gene	infusion|amod|START_ENTITY impairs|nsubj|infusion impairs|dobj|sensitivity sensitivity|compound|END_ENTITY	Nicotine infusion acutely impairs insulin sensitivity in type 2 diabetic patients but not in healthy subjects .
20220107	0	Nicotine	0,8	interleukin-6	20,33	Nicotine	interleukin-6	MESH:D009538	3569	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|production production|amod|END_ENTITY	Nicotine suppresses interleukin-6 production from vascular endothelial cells : a possible therapeutic role of nicotine for preeclampsia .
14568117	0	Nicotine	0,8	nerve_growth_factor	21,40	Nicotine	nerve growth factor	MESH:D009538	4803	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	Nicotine upregulates nerve_growth_factor expression and prevents apoptosis of cultured spinal cord neurons .
17015027	0	Nicotine	0,8	nicotinic_acetylcholine_receptors	76,109	Nicotine	nicotinic acetylcholine receptors	MESH:D009538	1137	Chemical	Gene	activates|nsubj|START_ENTITY activates|nmod|END_ENTITY	Nicotine activates cell-signaling pathways through muscle-type and neuronal nicotinic_acetylcholine_receptors in non-small_cell_lung_cancer cells .
10066866	0	Nicotine	0,8	plasminogen_activator_inhibitor-1	19,52	Nicotine	plasminogen activator inhibitor-1	MESH:D009538	5054	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|production production|amod|END_ENTITY	Nicotine increases plasminogen_activator_inhibitor-1 production by human brain endothelial cells via protein_kinase_C-associated pathway .
26472220	0	Nicotine	0,8	surfactant_proteins_A_and_D	31,58	Nicotine	surfactant proteins A and D	MESH:D009538	653509;6441	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|levels levels|nmod|END_ENTITY	Nicotine reduces the levels of surfactant_proteins_A_and_D via Wnt/b-catenin and PKC signaling in human airway epithelial cells .
20665032	0	Nicotine	0,8	tumor_necrosis_factor-a	18,41	Nicotine	tumor necrosis factor-a	MESH:D009538	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Nicotine inhibits tumor_necrosis_factor-a induced IL-6 and IL-8 secretion in fibroblast-like synoviocytes from patients with rheumatoid_arthritis .
20056136	0	Nicotine	0,8	tyrosine_kinase_receptor_A	59,85	Nicotine	tyrosine kinase receptor A	MESH:D009538	59109(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Nicotine increases the expression of neurotrophin receptor tyrosine_kinase_receptor_A in basal forebrain cholinergic neurons .
22261521	0	Nicotine	0,8	urokinase-type_plasminogen_activator_receptor	20,65	Nicotine	urokinase-type plasminogen activator receptor	MESH:D009538	5329	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Nicotine stimulates urokinase-type_plasminogen_activator_receptor expression and cell invasiveness through mitogen-activated protein kinase and reactive oxygen species signaling in ECV304 endothelial cells .
11839560	0	Nicotine	0,8	vascular_endothelial_growth_factor	34,68	Nicotine	vascular endothelial growth factor	MESH:D009538	7422	Chemical	Gene	START_ENTITY|dobj|expression expression|compound|END_ENTITY	Nicotine and cotinine up-regulate vascular_endothelial_growth_factor expression in endothelial cells .
18651290	0	Nicotine	0,8	vascular_endothelial_growth_factor	21,55	Nicotine	vascular endothelial growth factor	MESH:D009538	100008899(Tax:9986)	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|expression expression|compound|END_ENTITY	Nicotine potentiates vascular_endothelial_growth_factor expression in balloon-injured rabbit aortas .
9618217	0	Nicotinic_Acetylcholine	41,64	Rapsyn	22,28	Nicotinic Acetylcholine	Rapsyn	null	5913	Chemical	Gene	Receptors|compound|START_ENTITY Effects|nmod|Receptors Effects|nmod|END_ENTITY	Organizing Effects of Rapsyn on Neuronal Nicotinic_Acetylcholine Receptors .
26766039	0	Nicotinic_Acid	102,116	Insulin	0,7	Nicotinic Acid	Insulin	MESH:D009525	280829(Tax:9913)	Chemical	Gene	Supplemented|nmod|START_ENTITY Signaling|nmod|Supplemented Signaling|compound|END_ENTITY	Insulin Signaling in Liver and Adipose Tissues in Periparturient Dairy Cows Supplemented with Dietary Nicotinic_Acid .
22930813	0	Nicotinic_acid	0,14	APOA	32,36	Nicotinic acid	APOA	MESH:D009525	4018	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Nicotinic_acid inhibits hepatic APOA gene expression : studies in humans and in transgenic_mice .
20664170	0	Nicotinic_acid	0,14	GPR109A	66,73	Nicotinic acid	GPR109A	MESH:D009525	80885(Tax:10090)	Chemical	Gene	flushing|amod|START_ENTITY involves|nsubj|flushing involves|ccomp|expressed expressed|nsubj|END_ENTITY	Nicotinic_acid - and monomethyl_fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice .
21317532	0	Nicotinic_acid	0,14	GPR109A	84,91	Nicotinic acid	GPR109A	MESH:D009525	80885(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Nicotinic_acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells .
24675661	0	Nicotinic_acid	0,14	TRPV1	48,53	Nicotinic acid	TRPV1	MESH:D009525	7442	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Nicotinic_acid activates the capsaicin receptor TRPV1 : Potential mechanism for cutaneous flushing .
21664629	0	Nicotinic_acid	0,14	apolipoprotein_A-I	23,41	Nicotinic acid	apolipoprotein A-I	MESH:D009525	335	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Nicotinic_acid induces apolipoprotein_A-I gene expression in HepG2 and Caco-2 cell lines .
12102654	0	Nicotinic_acid-adenine_dinucleotide_phosphate	0,45	skeletal_muscle_ryanodine_receptor	60,94	Nicotinic acid-adenine dinucleotide phosphate	skeletal muscle ryanodine receptor	MESH:C024376	6261	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Nicotinic_acid-adenine_dinucleotide_phosphate activates the skeletal_muscle_ryanodine_receptor .
22932192	0	Nifedipine	0,10	Beclin1	37,44	Nifedipine	Beclin1	MESH:D009543	8678	Chemical	Gene	induced|nsubj|START_ENTITY induced|nmod|END_ENTITY	Nifedipine induced autophagy through Beclin1 and mTOR pathway in endometrial_carcinoma cells .
20460829	0	Nifedipine	0,10	Cu/ZnSOD	71,79	Nifedipine	Cu/ZnSOD	MESH:D009543	24786(Tax:10116)	Chemical	Gene	activates|nsubj|START_ENTITY activates|nmod|END_ENTITY	Nifedipine activates PPARgamma and exerts antioxidative action through Cu/ZnSOD independent of blood-pressure lowering in SHRSP .
21814214	0	Nifedipine	0,10	PGC-1a	54,60	Nifedipine	PGC-1a	MESH:D009543	19017(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|nmod|expression expression|compound|END_ENTITY	Nifedipine increases energy expenditure by increasing PGC-1a expression in skeletal muscle .
24004653	0	Nifedipine	0,10	TGF-beta	72,80	Nifedipine	TGF-beta	MESH:D009543	7040	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Nifedipine induces periostin expression in gingival fibroblasts through TGF-beta .
2452924	0	Nifedipine	0,10	angiotensin_II	73,87	Nifedipine	angiotensin II	MESH:D009543	183	Chemical	Gene	blunt|nsubj|START_ENTITY blunt|dobj|response response|nmod|END_ENTITY	Nifedipine does not blunt the aldosterone and cardiovascular response to angiotensin_II and potassium infusion in hypertensive patients .
8020177	0	Nifedipine	0,10	angiotensin_II	45,59	Nifedipine	angiotensin II	MESH:D009543	183	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|nmod|END_ENTITY	Nifedipine reduces pressor responsiveness to angiotensin_II in pregnant women .
16331110	0	Nifedipine	0,10	monocyte_chemoattractant_protein_1	44,78	Nifedipine	monocyte chemoattractant protein 1	MESH:D009543	24770(Tax:10116)	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|dobj|expression expression|amod|END_ENTITY	Nifedipine inhibited angiotensin_II-induced monocyte_chemoattractant_protein_1 expression : involvement of inhibitor of nuclear factor kappa B kinase and nuclear factor kappa B-inducing kinase .
7889637	0	Nifedipine	0,10	parathyroid_hormone	48,67	Nifedipine	parathyroid hormone	MESH:D009543	5741	Chemical	Gene	elevates|nsubj|START_ENTITY elevates|dobj|levels levels|amod|END_ENTITY	Nifedipine , but not verapamil , acutely elevates parathyroid_hormone levels in premenopausal women .
15553663	0	Nifedipine	0,10	receptor_for_advanced_glycation_end_products	39,83	Nifedipine	receptor for advanced glycation end products	MESH:D009543	177	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Nifedipine inhibits gene expression of receptor_for_advanced_glycation_end_products -LRB- RAGE -RRB- in endothelial cells by suppressing reactive_oxygen_species generation .
12832717	0	Nifedipine	0,10	renin	59,64	Nifedipine	renin	MESH:D009543	403838(Tax:9615)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|decrease decrease|nmod|activity activity|compound|END_ENTITY	Nifedipine inhibits the hypoxia-induced decrease in plasma renin activity in conscious dogs .
966384	0	Nifedipine	75,85	renin	40,45	Nifedipine	renin	MESH:D009543	5972	Chemical	Gene	antagonist|appos|START_ENTITY END_ENTITY|nmod|antagonist	Hypotensive action and increased plasma renin activity by Ca2 + antagonist -LRB- Nifedipine -RRB- in hypertensive patients .
21447991	0	Niflumic_Acid	0,13	MUC5AC	40,46	Niflumic Acid	MUC5AC	MESH:D009544	4586	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Niflumic_Acid Reduces Histamine-Induced MUC5AC Expression in Human Conjunctival Epithelial Cells .
8083179	0	Nikkomycin_Z	0,12	Chs3	89,93	Nikkomycin Z	Chs3	MESH:C011952	852311(Tax:4932)	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Nikkomycin_Z is a specific inhibitor of Saccharomyces_cerevisiae chitin synthase isozyme Chs3 in vitro and in vivo .
18092806	0	Nile_Red	0,8	cytochrome_P450_3A4	50,69	Nile Red	cytochrome P450 3A4	MESH:C044808	1576	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Nile_Red is a fluorescent allosteric substrate of cytochrome_P450_3A4 .
23063650	0	Nilotinib	0,9	ABCB1	60,65	Nilotinib	ABCB1	MESH:C498826	18669(Tax:10090)	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|dep|ABCG2 ABCG2|nmod|END_ENTITY	Nilotinib potentiates anticancer drug sensitivity in murine ABCB1 - , ABCG2 - , and ABCC10-multidrug resistance xenograft models .
17715389	0	Nilotinib	0,9	BCR-ABL	48,55	Nilotinib	BCR-ABL	MESH:C498826	25	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Nilotinib -LRB- formerly AMN107 -RRB- , a highly selective BCR-ABL tyrosine kinase inhibitor , is effective in patients with Philadelphia_chromosome-positive_chronic_myelogenous_leukemia in chronic phase following imatinib resistance and intolerance .
18922118	0	Nilotinib	0,9	BCR-ABL	69,76	Nilotinib	BCR-ABL	MESH:C498826	25	Chemical	Gene	START_ENTITY|parataxis|kinases kinases|nsubj|derivative derivative|nmod|activity activity|nmod|END_ENTITY	Nilotinib : a phenylamino-pyrimidine derivative with activity against BCR-ABL , KIT and PDGFR kinases .
20132660	0	Nilotinib	0,9	BCR-ABL	90,97	Nilotinib	BCR-ABL	MESH:C498826	25	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|apoptosis apoptosis|nmod|cells cells|nmod|END_ENTITY	Nilotinib significantly induces apoptosis in imatinib-resistant K562 cells with wild-type BCR-ABL , as effectively as in parental sensitive counterparts .
23502220	0	Nilotinib	0,9	BCR-ABL	52,59	Nilotinib	BCR-ABL	MESH:C498826	25	Chemical	Gene	associated|nsubjpass|START_ENTITY associated|nmod|incidence incidence|nmod|imatinib imatinib|nummod|END_ENTITY	Nilotinib is associated with a reduced incidence of BCR-ABL mutations vs imatinib in patients with newly diagnosed chronic_myeloid_leukemia in chronic phase .
24333114	0	Nilotinib	0,9	BCR-ABL	86,93	Nilotinib	BCR-ABL	MESH:C498826	25	Chemical	Gene	BID|compound|START_ENTITY BID|dep|analysis analysis|nmod|system system|compound|END_ENTITY	Nilotinib 300 mg BID as frontline treatment of CML : prospective analysis of the Xpert BCR-ABL monitor system and significance of 3-month molecular response .
26847385	0	Nilotinib	33,42	BCR-ABL	102,109	Nilotinib	BCR-ABL	MESH:C498826	25	Chemical	Gene	response|nmod|START_ENTITY END_ENTITY|nsubj|response	Complete cytogenetic response to Nilotinib in a chronic_myeloid_leukemia case with a rare e13a3 -LRB- b2a3 -RRB- BCR-ABL fusion transcript : A case report .
17642017	0	Nilotinib	17,26	Bcr-Abl	37,44	Nilotinib	Bcr-Abl	MESH:C498826	25	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Drug evaluation : Nilotinib - a novel Bcr-Abl tyrosine kinase inhibitor for the treatment of chronic_myelocytic_leukemia and beyond .
25382610	0	Nimbolide	0,9	BCL2	18,22	Nimbolide	BCL2	MESH:C042198	596	Chemical	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	Nimbolide targets BCL2 and induces apoptosis in preclinical models of Waldenstr __ ms_macroglobulinemia .
21078664	0	Nimbolide	0,9	TRAIL	49,54	Nimbolide	TRAIL	MESH:C042198	8743	Chemical	Gene	sensitizes|nsubj|START_ENTITY sensitizes|dobj|cells cells|acl|END_ENTITY	Nimbolide sensitizes human colon_cancer cells to TRAIL through reactive oxygen species - and ERK-dependent up-regulation of death receptors , p53 , and Bax .
24704252	0	Nimesulide	0,10	B0AT1	31,36	Nimesulide	B0AT1	MESH:C012655	664630(Tax:10116)	Chemical	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Nimesulide binding site in the B0AT1 -LRB- SLC6A19 -RRB- amino_acid transporter .
11249549	0	Nimesulide	0,10	COX-2	50,55	Nimesulide	COX-2	MESH:C012655	4513	Chemical	Gene	START_ENTITY|dep|NSAID NSAID|acl:relcl|inhibits inhibits|xcomp|END_ENTITY	Nimesulide : an NSAID that preferentially inhibits COX-2 , and has various unique pharmacological activities .
12378813	0	Nimesulide	1,11	COX-2	35,40	Nimesulide	COX-2	MESH:C012655	4513	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	-LSB- Nimesulide -LRB- Aulin -RRB- -- the selective COX-2 inhibitor in the treatment of ENT_diseases -RSB- .
15567877	0	Nimesulide	0,10	COX-2	14,19	Nimesulide	COX-2	MESH:C012655	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Nimesulide , a COX-2 inhibitor , does not reduce lesion size or number in a nude mouse model of endometriosis .
19046800	0	Nimesulide	0,10	COX-2	111,116	Nimesulide	COX-2	MESH:C012655	4513	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Nimesulide inhibits IFN-gamma-induced programmed_death-1-ligand_1 surface expression in breast_cancer cells by COX-2 and PGE2 independent mechanisms .
19360361	0	Nimesulide	0,10	COX-2	24,29	Nimesulide	COX-2	MESH:C012655	4513	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Nimesulide , a selective COX-2 inhibitor , acts synergistically with ionizing radiation against A549 human lung_cancer cells through the activation of caspase-8 and caspase-3 .
24298452	1	Nimesulide	79,89	COX-2	106,111	Nimesulide	COX-1	MESH:C012655	17708(Tax:10090)	Chemical	Gene	has|nsubj|START_ENTITY has|nsubj|inhibitor inhibitor|compound|END_ENTITY	AIM : Nimesulide , a preferential COX-2 inhibitor has 20 times more selectivity towards COX-2 than that of COX-1 .
11195195	0	Nimesulide	1,11	cyclooxygenase-2	69,85	Nimesulide	cyclooxygenase-2	MESH:C012655	5743	Chemical	Gene	START_ENTITY|dep|drug drug|appos|-RSB- -RSB-|amod|END_ENTITY	-LSB- Nimesulide - a non-steroidal anti-inflammatory drug , a preferential cyclooxygenase-2 inhibitor -RSB- .
11399097	0	Nimesulide	0,10	cyclooxygenase-2	45,61	Nimesulide	cyclooxygenase-2	MESH:C012655	5743	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|amod|END_ENTITY	Nimesulide reduces interleukin-1beta-induced cyclooxygenase-2 gene expression in human synovial fibroblasts .
14605244	0	Nimesulide	0,10	cyclooxygenase-2	14,30	Nimesulide	cyclooxygenase-2	MESH:C012655	100009248(Tax:9986)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Nimesulide , a cyclooxygenase-2 preferential inhibitor , impairs renal function in the newborn rabbit .
15312381	0	Nimesulide	1,11	cyclooxygenase-2	25,41	Nimesulide	cyclooxygenase-2	MESH:C012655	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	-LSB- Nimesulide , a selective cyclooxygenase-2 inhibitor inhibits telomerase activity by blocking activation of PKB in gastric_cancer cell line -RSB- .
11840453	0	Nimesulide	0,10	cyclooxygenase_2	122,138	Nimesulide	cyclooxygenase 2	MESH:C012655	5743	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|induction induction|nmod|expression expression|amod|END_ENTITY	Nimesulide , a preferential cyclooxygenase_2 inhibitor , suppresses peroxisome_proliferator-activated_receptor induction of cyclooxygenase_2 gene expression in human synovial fibroblasts : evidence for receptor antagonism .
11840453	0	Nimesulide	0,10	cyclooxygenase_2	27,43	Nimesulide	cyclooxygenase 2	MESH:C012655	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Nimesulide , a preferential cyclooxygenase_2 inhibitor , suppresses peroxisome_proliferator-activated_receptor induction of cyclooxygenase_2 gene expression in human synovial fibroblasts : evidence for receptor antagonism .
19046800	0	Nimesulide	0,10	programmed_death-1-ligand_1	38,65	Nimesulide	programmed death-1-ligand 1	MESH:C012655	29126	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Nimesulide inhibits IFN-gamma-induced programmed_death-1-ligand_1 surface expression in breast_cancer cells by COX-2 and PGE2 independent mechanisms .
9839538	0	Nimesulide	0,10	tumor_necrosis_factor-alpha	67,94	Nimesulide	tumor necrosis factor-alpha	MESH:C012655	24835(Tax:10116)	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|nmod|END_ENTITY	Nimesulide prevents lipopolysaccharide-induced elevation in plasma tumor_necrosis_factor-alpha in rats .
15315172	0	Nimodipine	0,10	Bcl-2	21,26	Nimodipine	Bcl-2	MESH:D009553	24224(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	Nimodipine modulates Bcl-2 and Bax mRNA expression after cerebral_ischemia .
22803321	0	Nimodipine	0,10	CGRP	26,30	Nimodipine	CGRP	MESH:D009553	24241(Tax:10116)	Chemical	Gene	down-regulates|amod|START_ENTITY END_ENTITY|nsubj|down-regulates	Nimodipine down-regulates CGRP expression in the rat trigeminal nucleus caudalis .
22831460	0	Nimodipine	0,10	IL-1b	20,25	Nimodipine	IL-1b	MESH:D009553	16176(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|compound|END_ENTITY	Nimodipine inhibits IL-1b release stimulated by amyloid b from microglia .
25204460	0	Nimodipine	0,10	TrkB	21,25	Nimodipine	TrkB	MESH:D009553	18212(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|Receptors Receptors|compound|END_ENTITY	Nimodipine Activates TrkB Neurotrophin Receptors and Induces Neuroplastic and Neuroprotective Signaling Events in the Mouse Hippocampus and Prefrontal Cortex .
12359266	0	Nipradilol	0,10	caspase-3	62,71	Nipradilol	caspase-3	MESH:C036089	25402(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|preventing preventing|dobj|activation activation|nmod|END_ENTITY	Nipradilol inhibits apoptosis by preventing the activation of caspase-3 via S-nitrosylation and the cGMP-dependent pathway .
25451059	0	Nitazoxanide	22,34	Neuraminidase	40,53	Nitazoxanide	Neuraminidase	MESH:C041747	4758	Chemical	Gene	START_ENTITY|nmod|Inhibitors Inhibitors|compound|END_ENTITY	Synergistic Effect of Nitazoxanide with Neuraminidase Inhibitors against Influenza_A Viruses In Vitro .
10369086	0	Nitecapone	0,10	myeloperoxidase	20,35	Nitecapone	myeloperoxidase	MESH:C057364	303413(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Nitecapone inhibits myeloperoxidase in vitro and enhances functional performance after 8 h of ischemia in experimental heart transplantation .
24135452	0	Nitensidine_A	0,13	ABCB1	106,111	Nitensidine A	ABCB1	null	5243	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Nitensidine_A , a guanidine_alkaloid from Pterogyne nitens , is a novel substrate for human ABC transporter ABCB1 .
25530218	0	Nitidine_chloride	0,17	p53	104,107	Nitidine chloride	p53	MESH:C013615	7157	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|pathway pathway|nmod|END_ENTITY	Nitidine_chloride induces apoptosis in human hepatocellular_carcinoma cells through a pathway involving p53 , p21 , Bax and Bcl-2 .
20072908	0	Nitrate	0,7	ALDH-2	68,74	Nitrate	ALDH-2	CHEBI:48107	217	Chemical	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Nitrate reductase activity of mitochondrial aldehyde dehydrogenase -LRB- ALDH-2 -RRB- as a redox sensor for cardiovascular oxidative stress .
26151852	0	Nitrate	0,7	C2/C3	76,81	Nitrate	C2/C3	CHEBI:48107	718	Chemical	Gene	removal|amod|START_ENTITY removal|nmod|END_ENTITY	Nitrate removal by organotrophic anaerobic ammonium oxidizing bacteria with C2/C3 fatty_acid in upflow anaerobic sludge blanket reactors .
18024571	0	Nitrate	0,7	NIT2	41,45	Nitrate	NIT2	CHEBI:48107	5728827(Tax:3055)	Chemical	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Nitrate signaling by the regulatory gene NIT2 in Chlamydomonas .
24084651	0	Nitrate	0,7	NRT1	71,75	Nitrate	NRT1	CHEBI:48107	837763(Tax:3702)	Chemical	Gene	compete|nsubj|START_ENTITY compete|nmod|AIT1 AIT1|dep|.2 .2|compound|END_ENTITY	Nitrate does not compete with abscisic_acid as a substrate of AtNPF4 .6 / NRT1 .2 / AIT1 in Arabidopsis .
24642706	0	Nitrate	0,7	NRT1	84,88	Nitrate	NRT1	CHEBI:48107	837763(Tax:3702)	Chemical	Gene	regulation|amod|START_ENTITY depends|nsubj|regulation depends|nmod|function function|compound|END_ENTITY	Nitrate regulation of AFB3_and_NAC4 gene expression in Arabidopsis roots depends on NRT1 .1 nitrate transport function .
22432443	0	Nitrate	0,7	NRT2	55,59	Nitrate	NRT2	CHEBI:48107	837327(Tax:3702)	Chemical	Gene	capacity|amod|START_ENTITY capacity|nmod|members members|compound|END_ENTITY	Nitrate transport capacity of the Arabidopsis_thaliana NRT2 family members and their interactions with AtNAR2 .1 .
25798624	0	Nitrate	15,22	NRT2	134,138	Nitrate	NRT2	CHEBI:48107	542864(Tax:4565)	Chemical	Gene	Uptake|compound|START_ENTITY Controlled|nsubjpass|Uptake Controlled|nmod|Role Role|nmod|END_ENTITY	Post-Flowering Nitrate Uptake in Wheat Is Controlled by N Status at Flowering , with a Putative Major Role of Root Nitrate Transporter NRT2 .1 .
16668807	0	Nitrate	11,18	Phosphoenolpyruvate_Carboxylase	54,85	Nitrate	Phosphoenolpyruvate Carboxylase	CHEBI:48107	100101511(Tax:4577)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|Expression Expression|nmod|END_ENTITY	Effects of Nitrate and Ammonium on Gene Expression of Phosphoenolpyruvate_Carboxylase and Nitrogen Metabolism in Maize Leaf Tissue during Recovery from Nitrogen Stress .
16659756	0	Nitrate	0,7	Reductase	8,17	Nitrate	Reductase	CHEBI:48107	547911(Tax:3847)	Chemical	Gene	START_ENTITY|dobj|Activity Activity|compound|END_ENTITY	Nitrate Reductase Activity in Soybeans -LRB- Glycine_max _ -LSB- L. -RSB- _ Merr . -RRB-
16661245	0	Nitrate	33,40	Reductase	41,50	Nitrate	Reductase	CHEBI:48107	547911(Tax:3847)	Chemical	Gene	Activities|compound|START_ENTITY Activities|compound|END_ENTITY	Development of NAD -LRB- P -RRB- H : and NADH : Nitrate Reductase Activities in Soybean Cotyledons .
16662132	0	Nitrate	46,53	Reductase	54,63	Nitrate	Reductase	CHEBI:48107	547911(Tax:3847)	Chemical	Gene	Assay|compound|START_ENTITY Assay|compound|END_ENTITY	Evolution of Nitrogen_Oxide -LRB- s -RRB- during In Vivo Nitrate Reductase Assay of Soybean Leaves .
16663781	0	Nitrate	56,63	Reductase	64,73	Nitrate	Reductase	CHEBI:48107	547911(Tax:3847)	Chemical	Gene	Assay|compound|START_ENTITY Assay|compound|END_ENTITY	Acetaldehyde_Oxime , A Product Formed during the In Vivo Nitrate Reductase Assay of Soybean Leaves .
16665099	0	Nitrate	88,95	Reductase	96,105	Nitrate	Reductase	CHEBI:48107	547911(Tax:3847)	Chemical	Gene	Assay|compound|START_ENTITY Assay|compound|END_ENTITY	Nitric_Oxide and Nitrous_Oxide Production by Soybean and Winged Bean during the in Vivo Nitrate Reductase Assay .
23196075	0	Nitrate	50,57	Reductase	58,67	Nitrate	Reductase	CHEBI:48107	547911(Tax:3847)	Chemical	Gene	Activity|compound|START_ENTITY Activity|compound|END_ENTITY	A Role for manganese in the Regulation of Soybean Nitrate Reductase Activity ?
24531490	0	Nitrate	0,7	protein_tyrosine_phosphatase_1B	30,61	Nitrate	protein tyrosine phosphatase 1B	CHEBI:48107	5770	Chemical	Gene	START_ENTITY|nmod|site site|nmod|END_ENTITY	Nitrate in the active site of protein_tyrosine_phosphatase_1B is a putative mimetic of the transition state .
26378238	0	Nitric-Oxide	29,41	Dystrophin	68,78	Nitric-Oxide	Dystrophin	MESH:D009569	1756	Chemical	Gene	Interaction|compound|START_ENTITY Interaction|nmod|END_ENTITY	Structural Basis of Neuronal Nitric-Oxide Synthase Interaction with Dystrophin Repeats 16 and 17 .
20511233	0	Nitric-oxide	0,12	cytoglobin	43,53	Nitric-oxide	cytoglobin	MESH:D009569	114757	Chemical	Gene	function|amod|START_ENTITY function|nmod|END_ENTITY	Nitric-oxide dioxygenase function of human cytoglobin with cellular reductants and in rat hepatocytes .
25414768	0	Nitric_Oxide	54,66	AP-1	149,153	Nitric Oxide	AP-1	MESH:D009569	16476(Tax:10090)	Chemical	Gene	Production|compound|START_ENTITY Production|nmod|END_ENTITY	TI-I-174 , a Synthetic Chalcone Derivative , Suppresses Nitric_Oxide Production in Murine Macrophages via Heme_Oxygenase-1 Induction and Inhibition of AP-1 .
25652185	0	Nitric_Oxide	53,65	Acetylcholinesterase	0,20	Nitric Oxide	Acetylcholinesterase	MESH:D009569	43	Chemical	Gene	Mobilization|compound|START_ENTITY Mobilization|compound|END_ENTITY	Acetylcholinesterase Conformational States Influence Nitric_Oxide Mobilization in the Erythrocyte .
24627754	0	Nitric_Oxide	39,51	Angiotensin_II	75,89	Nitric Oxide	Angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	Response|compound|START_ENTITY Response|nmod|Administration Administration|compound|END_ENTITY	Role of Angiotensin_Type_2_Receptor on Nitric_Oxide Production Response to Angiotensin_II Administration in Ovariectomised Rats Treated with Estradiol .
26549290	0	Nitric_Oxide	14,26	Angiotensin_II_Type_1_Receptor	39,69	Nitric Oxide	Angiotensin II Type 1 Receptor	MESH:D009569	81638(Tax:10116)	Chemical	Gene	Donor|compound|START_ENTITY Donor|nmod|Blocker Blocker|compound|END_ENTITY	Addition of a Nitric_Oxide Donor to an Angiotensin_II_Type_1_Receptor Blocker May Cancel Its Blood Pressure-Lowering Effects .
24627754	0	Nitric_Oxide	39,51	Angiotensin_Type_2_Receptor	8,35	Nitric Oxide	Angiotensin Type 2 Receptor	MESH:D009569	24182(Tax:10116)	Chemical	Gene	Response|compound|START_ENTITY END_ENTITY|nmod|Response	Role of Angiotensin_Type_2_Receptor on Nitric_Oxide Production Response to Angiotensin_II Administration in Ovariectomised Rats Treated with Estradiol .
26430901	0	Nitric_Oxide	88,100	Calcitonin_Gene-Related_Peptide	0,31	Nitric Oxide	Calcitonin Gene-Related Peptide	MESH:D009569	796	Chemical	Gene	Inflammation|nmod|START_ENTITY Inflammation|compound|END_ENTITY	Calcitonin_Gene-Related_Peptide Improves Hypoxia-Induced Inflammation and Apoptosis via Nitric_Oxide in H9c2 Cardiomyoblast Cells .
27044361	0	Nitric_Oxide	40,52	Cyclooxygenase-2	8,24	Nitric Oxide	Cyclooxygenase-2	MESH:D009569	100009248(Tax:9986)	Chemical	Gene	Relation|nmod|START_ENTITY END_ENTITY|nmod|Relation	Role of Cyclooxygenase-2 in Relation to Nitric_Oxide and Endothelin-1 on Pathogenesis of Cerebral_Vasospasm After Subarachnoid_Hemorrhage in Rabbit .
25857313	0	Nitric_Oxide	52,64	Dimethylarginine_Dimethylaminohydrolase_2	0,41	Nitric Oxide	Dimethylarginine Dimethylaminohydrolase 2	MESH:D009569	51793(Tax:10090)	Chemical	Gene	Synthesis|compound|START_ENTITY Regulates|dobj|Synthesis Regulates|nsubj|END_ENTITY	Dimethylarginine_Dimethylaminohydrolase_2 Regulates Nitric_Oxide Synthesis and Hemodynamics and Determines Outcome in Polymicrobial Sepsis .
25043647	0	Nitric_Oxide	80,92	ENOS	107,111	Nitric Oxide	ENOS	MESH:D009569	4846	Chemical	Gene	Efficacy|nmod|START_ENTITY recruited|nmod|Efficacy recruited|nmod|trial trial|appos|END_ENTITY	Baseline characteristics of the 4011 patients recruited into the Efficacy of Nitric_Oxide in Stroke -LRB- ENOS -RRB- trial .
26645254	0	Nitric_Oxide	85,97	ENOS	109,113	Nitric Oxide	ENOS	MESH:D009569	4846	Chemical	Gene	START_ENTITY|nmod|Trial Trial|appos|END_ENTITY	Glyceryl_Trinitrate for Acute Intracerebral_Hemorrhage : Results From the Efficacy of Nitric_Oxide in Stroke -LRB- ENOS -RRB- Trial , a Subgroup Analysis .
26008990	0	Nitric_Oxide	64,76	Endothelial_Nitric_Oxide_Synthase	106,139	Nitric Oxide	Endothelial Nitric Oxide Synthase	MESH:D009569	4846	Chemical	Gene	Production|compound|START_ENTITY Production|nmod|Activation Activation|nmod|END_ENTITY	Pterostilbene , an Active Constituent of Blueberries , Stimulates Nitric_Oxide Production via Activation of Endothelial_Nitric_Oxide_Synthase in Human Umbilical Vein Endothelial Cells .
26008990	0	Nitric_Oxide	64,76	Endothelial_Nitric_Oxide_Synthase	106,139	Nitric Oxide	Endothelial Nitric Oxide Synthase	MESH:D009569	4846	Chemical	Gene	Production|compound|START_ENTITY Production|nmod|Activation Activation|nmod|END_ENTITY	Pterostilbene , an Active Constituent of Blueberries , Stimulates Nitric_Oxide Production via Activation of Endothelial_Nitric_Oxide_Synthase in Human Umbilical Vein Endothelial Cells .
26824621	0	Nitric_Oxide	124,136	Endothelial_Nitric_Oxide_Synthase	200,233	Nitric Oxide	Endothelial Nitric Oxide Synthase	MESH:D009569	4846	Chemical	Gene	Production|nmod|START_ENTITY Tang|appos|Production Tang|dep|Mediated Mediated|nmod|Phosphorylation Phosphorylation|nmod|END_ENTITY	Danggui Buxue Tang , Chinese Herbal Decoction Containing Astragali Radix and Angelicae Sinensis Radix , Induces Production of Nitric_Oxide in Endothelial Cells : Signaling Mediated by Phosphorylation of Endothelial_Nitric_Oxide_Synthase .
25414768	0	Nitric_Oxide	54,66	Heme_Oxygenase-1	104,120	Nitric Oxide	Heme Oxygenase-1	MESH:D009569	15368(Tax:10090)	Chemical	Gene	Production|compound|START_ENTITY Production|nmod|Macrophages Macrophages|nmod|Induction Induction|compound|END_ENTITY	TI-I-174 , a Synthetic Chalcone Derivative , Suppresses Nitric_Oxide Production in Murine Macrophages via Heme_Oxygenase-1 Induction and Inhibition of AP-1 .
25744452	0	Nitric_Oxide	0,12	Heme_Oxygenase-1	42,58	Nitric Oxide	Heme Oxygenase-1	MESH:D009569	15368(Tax:10090)	Chemical	Gene	Regulator|nsubj|START_ENTITY Regulator|nmod|Expression Expression|compound|END_ENTITY	Nitric_Oxide Is an Important Regulator of Heme_Oxygenase-1 Expression in the Lipopolysaccharide and Interferon-y-Treated Murine Macrophage-Like Cell Line J774 .1 / JA-4 .
25853810	0	Nitric_Oxide	0,12	IL-1b	22,27	Nitric Oxide	IL-1b	MESH:D009569	3553	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Nitric_Oxide Sustains IL-1b Expression in Human Dendritic Cells Enhancing Their Capacity to Induce IL-17-Producing T-Cells .
23675265	0	Nitric_Oxide	127,139	Insulin	42,49	Nitric Oxide	Insulin	MESH:D009569	3630	Chemical	Gene	Talk|nmod|START_ENTITY Talk|nmod|END_ENTITY	The `` Cross Talk '' between the Receptors of Insulin , Estrogen and Progesterone in Neutrophils in the Synthesis of Maspin through Nitric_Oxide in Breast_Cancer .
23675270	0	Nitric_Oxide	128,140	Insulin	98,105	Nitric Oxide	Insulin	MESH:D009569	3630	Chemical	Gene	Production|compound|START_ENTITY Stimulation|nmod|Production Induced|nmod|Stimulation Induced|nmod|Synthesis Synthesis|nmod|END_ENTITY	The Control of Stress Induced Type_I_Diabetes_Mellitus in Humans through the Hepatic Synthesis of Insulin by the Stimulation of Nitric_Oxide Production .
26674844	0	Nitric_Oxide	65,77	Interleukin-10	10,24	Nitric Oxide	Interleukin-10	MESH:D009569	3586	Chemical	Gene	Synthase|compound|START_ENTITY Stress|nmod|Synthase Stress|nsubj|Effect Effect|nmod|END_ENTITY	Effect of Interleukin-10 and Laminar Shear Stress on Endothelial Nitric_Oxide Synthase and Nitric_Oxide in African American Human Umbilical Vein Endothelial Cells .
22807935	0	Nitric_Oxide	72,84	Maspin	51,57	Nitric Oxide	Maspin	MESH:D009569	5268	Chemical	Gene	Production|compound|START_ENTITY Synthesis|nmod|Production Synthesis|compound|END_ENTITY	The Role of Neutrophil Estrogen Receptor Status on Maspin Synthesis via Nitric_Oxide Production in Human Breast_Cancer .
23675265	0	Nitric_Oxide	127,139	Maspin	112,118	Nitric Oxide	Maspin	MESH:D009569	5268	Chemical	Gene	Talk|nmod|START_ENTITY Talk|nmod|END_ENTITY	The `` Cross Talk '' between the Receptors of Insulin , Estrogen and Progesterone in Neutrophils in the Synthesis of Maspin through Nitric_Oxide in Breast_Cancer .
26759534	0	Nitric_Oxide	139,151	Maspin	77,83	Nitric Oxide	Maspin	MESH:D009569	5268	Chemical	Gene	Synthesis|compound|START_ENTITY Neutralization|nmod|Synthesis Neutralization|nmod|Acetyl_Salicylic_Acid Acetyl_Salicylic_Acid|nmod|Stimulated Stimulated|compound|END_ENTITY	Neutralization by Acetyl_Salicylic_Acid of the Testosterone induced Impaired Maspin Synthesis Stimulated by Estriol in Neutrophils through Nitric_Oxide Synthesis .
18036230	0	Nitric_Oxide	48,60	NF-kappaB	29,38	Nitric Oxide	NF-kappaB	MESH:D009569	18033(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY mediated|dobj|production mediated|nsubj|Modulation Modulation|nmod|END_ENTITY	Modulation of LPS stimulated NF-kappaB mediated Nitric_Oxide production by PKCepsilon and JAK2 in RAW macrophages .
25542028	0	Nitric_Oxide	0,12	NOS	23,26	Nitric Oxide	NOS	MESH:D009569	4843	Chemical	Gene	Inhibition|compound|START_ENTITY Inhibition|appos|END_ENTITY	Nitric_Oxide Synthase -LRB- NOS -RRB- Inhibition during Porcine In Vitro Maturation Modifies Oocyte Protein S-Nitrosylation and In Vitro Fertilization .
26866567	0	Nitric_Oxide	37,49	NOS3	65,69	Nitric Oxide	NOS3	MESH:D009569	4846	Chemical	Gene	START_ENTITY|dobj|Polymorphisms Polymorphisms|appos|END_ENTITY	The Relationship Between Endothelial Nitric_Oxide Synthase Gene -LRB- NOS3 -RRB- Polymorphisms , NOS3 Expression , and Varicocele .
26760532	0	Nitric_Oxide	9,21	Protease-Activated_Receptor_2	46,75	Nitric Oxide	Protease-Activated Receptor 2	MESH:D009569	116677(Tax:10116)	Chemical	Gene	Activation|compound|START_ENTITY Activation|nmod|END_ENTITY	Enhanced Nitric_Oxide Synthase Activation via Protease-Activated_Receptor_2 Is Involved in the Preserved Vasodilation in Aortas from Metabolic Syndrome Rats .
10684519	0	Nitric_Oxide	0,12	Renin	23,28	Nitric Oxide	Renin	MESH:D009569	5972	Chemical	Gene	Regulates|nsubj|START_ENTITY Regulates|xcomp|Release Release|compound|END_ENTITY	Nitric_Oxide Regulates Renin Release During Salt Depletion but Does Not Alter Angiotensin Responses in Normal Humans .
25383232	0	Nitric_Oxide	141,153	Somatostatin	54,66	Nitric Oxide	Somatostatin	MESH:D009569	20604(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Contrasting Effects of the Neuropeptides Substance_P , Somatostatin , and Neuropeptide Y on the Methamphetamine-Induced Production of Striatal Nitric_Oxide in Mice .
25383232	0	Nitric_Oxide	141,153	Substance_P	41,52	Nitric Oxide	Substance P	MESH:D009569	21333(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|Somatostatin Somatostatin|compound|END_ENTITY	Contrasting Effects of the Neuropeptides Substance_P , Somatostatin , and Neuropeptide Y on the Methamphetamine-Induced Production of Striatal Nitric_Oxide in Mice .
26842246	0	Nitric_Oxide	80,92	TACE	135,139	Nitric Oxide	TACE	MESH:D009569	11491(Tax:10090)	Chemical	Gene	Inhibition|compound|START_ENTITY Inhibition|nmod|END_ENTITY	Alcohol Decreases Organic Dust-Stimulated Airway Epithelial TNF-Alpha Through a Nitric_Oxide and Protein_Kinase-Mediated Inhibition of TACE .
18955363	0	Nitric_Oxide	92,104	THP-1	136,141	Nitric Oxide	THP-1	MESH:D009569	2736	Chemical	Gene	Levels|nmod|START_ENTITY Downregulate|dobj|Levels Downregulate|nmod|Cells Cells|compound|END_ENTITY	Hypericum triquetrifolium-Derived Factors Downregulate the Production Levels of LPS-Induced Nitric_Oxide and Tumor_Necrosis_Factor-a in THP-1 Cells .
26842246	0	Nitric_Oxide	80,92	TNF-Alpha	60,69	Nitric Oxide	TNF-Alpha	MESH:D009569	21926(Tax:10090)	Chemical	Gene	Inhibition|compound|START_ENTITY END_ENTITY|dep|Inhibition	Alcohol Decreases Organic Dust-Stimulated Airway Epithelial TNF-Alpha Through a Nitric_Oxide and Protein_Kinase-Mediated Inhibition of TACE .
22837686	0	Nitric_Oxide	19,31	Toll-Like_Receptor_4	112,132	Nitric Oxide	Toll-Like Receptor 4	MESH:D009569	29260(Tax:10116)	Chemical	Gene	Levels|nsubj|START_ENTITY Levels|nmod|Expression Expression|nmod|END_ENTITY	Pu-erh Tea Reduces Nitric_Oxide Levels in Rats by Inhibiting Inducible Nitric_Oxide Synthase Expression through Toll-Like_Receptor_4 .
22837686	0	Nitric_Oxide	71,83	Toll-Like_Receptor_4	112,132	Nitric Oxide	Toll-Like Receptor 4	MESH:D009569	29260(Tax:10116)	Chemical	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	Pu-erh Tea Reduces Nitric_Oxide Levels in Rats by Inhibiting Inducible Nitric_Oxide Synthase Expression through Toll-Like_Receptor_4 .
26133549	0	Nitric_Oxide	0,12	VE-Cadherin	74,85	Nitric Oxide	VE-Cadherin	MESH:D009569	307618(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|Expression Expression|compound|END_ENTITY	Nitric_Oxide Increases Arterial Endotheial Permeability through Mediating VE-Cadherin Expression during Arteriogenesis .
25593639	0	Nitric_Oxide	122,134	Vascular_Endothelial_Growth_Factor	54,88	Nitric Oxide	Vascular Endothelial Growth Factor	MESH:D009569	7422	Chemical	Gene	Production|compound|START_ENTITY Expression|nmod|Production Expression|compound|END_ENTITY	Thymosin_Beta-4 , Actin-Sequestering Protein Regulates Vascular_Endothelial_Growth_Factor Expression via Hypoxia-Inducible Nitric_Oxide Production in HeLa Cervical_Cancer Cells .
26799210	0	Nitric_Oxide	8,20	Vascular_Endothelial_Growth_Factor	86,120	Nitric Oxide	Vascular Endothelial Growth Factor	MESH:D009569	22339(Tax:10090)	Chemical	Gene	Isoforms|compound|START_ENTITY Role|nmod|Isoforms Role|nmod|Lungs Lungs|compound|END_ENTITY	Role of Nitric_Oxide Isoforms in Vascular and Alveolar Development and Lung_Injury in Vascular_Endothelial_Growth_Factor Overexpressing Neonatal Mice Lungs .
24723332	0	Nitric_Oxide	49,61	eNOS	97,101	Nitric Oxide	eNOS	MESH:D009569	24600(Tax:10116)	Chemical	Gene	Bioavailability|compound|START_ENTITY Pressure|nmod|Bioavailability Pressure|nmod|Modulation Modulation|nmod|END_ENTITY	Asiatic_Acid Reduces Blood Pressure by Enhancing Nitric_Oxide Bioavailability with Modulation of eNOS and p47 -LRB- phox -RRB- Expression in l-NAME-induced Hypertensive Rats .
26682617	0	Nitric_Oxide	77,89	eNOS	100,104	Nitric Oxide	eNOS	MESH:D009569	4846	Chemical	Gene	Synthase|compound|START_ENTITY Synthase|appos|END_ENTITY	Triterpenoic_Acids from Apple Pomace Enhance the Activity of the Endothelial Nitric_Oxide Synthase -LRB- eNOS -RRB- .
21792376	0	Nitric_Oxide	24,36	iNOS	47,51	Nitric Oxide	iNOS	MESH:D009569	4843	Chemical	Gene	Synthase|compound|START_ENTITY Synthase|appos|END_ENTITY	Regulation of Inducible Nitric_Oxide Synthase -LRB- iNOS -RRB- and its Potential Role in Insulin Resistance , Diabetes and Heart_Failure .
8812641	0	Nitric_Oxide	79,91	iNOS	39,43	Nitric Oxide	iNOS	MESH:D009569	24599(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Evaluate|dobj|Role Use|acl|Evaluate Use|nmod|Aminoguanidine Aminoguanidine|appos|Inhibitor Inhibitor|compound|END_ENTITY	The Use of Aminoguanidine , a Selective iNOS Inhibitor , to Evaluate the Role of Nitric_Oxide in the Development of Autoimmune_Diabetes Insulin-dependent_diabetes_mellitus is an autoimmune_disease characterized by the selective destruction of insulin-secreting beta cells found in islets of Langerhans .
10227231	0	Nitric_oxide	0,12	ABO_blood_group	13,28	Nitric oxide	ABO blood group	MESH:D009569	28	Chemical	Gene	START_ENTITY|dobj|difference difference|amod|END_ENTITY	Nitric_oxide ABO_blood_group difference in children .
21724667	0	Nitric_oxide	0,12	ADHD	96,100	Nitric oxide	NOS1	MESH:D009569	4842	Chemical	Gene	modulation|amod|START_ENTITY END_ENTITY|nsubj|modulation	Nitric_oxide synthase genotype modulation of impulsivity and ventral striatal activity in adult ADHD patients and healthy comparison subjects .
11399048	0	Nitric_oxide	0,12	AP-1	89,93	Nitric oxide	AP-1	MESH:D009569	16476(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|advcl|inhibiting inhibiting|dobj|activation activation|compound|END_ENTITY	Nitric_oxide suppresses IL-8 transcription by inhibiting c-Jun N-terminal kinase-induced AP-1 activation .
24951820	0	Nitric_oxide	0,12	BAFF	23,27	Nitric oxide	BAFF	MESH:D009569	24099(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Nitric_oxide regulates BAFF expression and T cell-independent antibody responses .
11592958	0	Nitric_oxide	0,12	BNIP3	64,69	Nitric oxide	BNIP3	MESH:D009569	12176(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|nmod|END_ENTITY	Nitric_oxide suppresses the expression of Bcl-2 binding protein BNIP3 in hepatocytes .
15358175	0	Nitric_oxide	0,12	BNIP3	21,26	Nitric oxide	BNIP3	MESH:D009569	12176(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nummod|END_ENTITY	Nitric_oxide induces BNIP3 expression that causes cell death in macrophages .
17875988	0	Nitric_oxide	0,12	CD25	25,29	Nitric oxide	CD25	MESH:D009569	16184(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Nitric_oxide induces CD4 + CD25 + Foxp3 regulatory T cells from CD4 + CD25 T cells via p53 , IL-2 , and OX40 .
17875988	0	Nitric_oxide	0,12	CD25	65,69	Nitric oxide	CD25	MESH:D009569	16184(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|CD25 CD25|acl|+ +|nmod|cells cells|compound|END_ENTITY	Nitric_oxide induces CD4 + CD25 + Foxp3 regulatory T cells from CD4 + CD25 T cells via p53 , IL-2 , and OX40 .
17875988	0	Nitric_oxide	0,12	CD4	61,64	Nitric oxide	CD4	MESH:D009569	12504(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|CD25 CD25|acl|+ +|nmod|cells cells|compound|END_ENTITY	Nitric_oxide induces CD4 + CD25 + Foxp3 regulatory T cells from CD4 + CD25 T cells via p53 , IL-2 , and OX40 .
10903767	0	Nitric_oxide	0,12	COX-1	61,66	Nitric oxide	COX-1	MESH:D009569	17708(Tax:10090)	Chemical	Gene	cross-talk|amod|START_ENTITY cross-talk|parataxis|activates activates|dobj|END_ENTITY	Nitric_oxide synthase/COX cross-talk : nitric_oxide activates COX-1 but inhibits COX-2-derived prostaglandin production .
16140209	0	Nitric_oxide	0,12	COX-2	63,68	Nitric oxide	COX-2	MESH:D009569	29527(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|apoptosis apoptosis|nmod|upregulation upregulation|nmod|END_ENTITY	Nitric_oxide induces apoptosis via AP-1-driven upregulation of COX-2 in rat pheochromocytoma cells .
16705145	0	Nitric_oxide	0,12	COX-2	24,29	Nitric oxide	COX-2	MESH:D009569	4513	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	Nitric_oxide stimulates COX-2 expression in cultured collecting duct cells through MAP kinases and superoxide but not cGMP .
12368293	0	Nitric_oxide	0,12	CREB	133,137	Nitric oxide	CREB	MESH:D009569	1385	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|apoptosis apoptosis|acl|induced induced|nmod|activation activation|appos|END_ENTITY	Nitric_oxide protects neuroblastoma cells from apoptosis induced by serum deprivation through cAMP-response_element-binding_protein -LRB- CREB -RRB- activation .
20447464	0	Nitric_oxide	0,12	CREB	47,51	Nitric oxide	CREB	MESH:D009569	1385	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Nitric_oxide induction of IRE1-alpha-dependent CREB phosphorylation in human glioma cells .
8574661	0	Nitric_oxide	0,12	CREB	92,96	Nitric oxide	CREB	MESH:D009569	81646(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|phosphorylation phosphorylation|appos|END_ENTITY	Nitric_oxide induces c-fos gene expression via cyclic_AMP_response_element_binding_protein -LRB- CREB -RRB- phosphorylation in rat retinal_pigment_epithelium .
10563648	0	Nitric_oxide	0,12	CSF	28,31	Nitric oxide	CSF	MESH:D009569	1437	Chemical	Gene	metabolites|amod|START_ENTITY metabolites|nmod|END_ENTITY	Nitric_oxide metabolites in CSF of patients with MS are related to clinical disease course .
18986693	0	Nitric_oxide	0,12	CXCL10	77,83	Nitric oxide	CXCL10	MESH:D009569	3627	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	Nitric_oxide inhibits human rhinovirus-induced transcriptional activation of CXCL10 in airway epithelial cells .
22765302	0	Nitric_oxide	0,12	EIN2	60,64	Nitric oxide	EIN2	MESH:D009569	831889(Tax:3702)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Nitric_oxide regulates dark-induced leaf senescence through EIN2 in Arabidopsis .
19779140	0	Nitric_oxide	0,12	EMMPRIN	112,119	Nitric oxide	EMMPRIN	MESH:D009569	12215(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Nitric_oxide induces the progression of abdominal_aortic_aneurysms through the matrix metalloproteinase inducer EMMPRIN .
10744637	0	Nitric_oxide	0,12	ERK	104,107	Nitric oxide	ERK	MESH:D009569	24338(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|xcomp|vascular vascular|nmod|suppression suppression|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Nitric_oxide reduces vascular smooth muscle cell elastase activity through cGMP-mediated suppression of ERK phosphorylation and AML1B nuclear partitioning .
10872747	0	Nitric_oxide	0,12	ERK	76,79	Nitric oxide	ERK	MESH:D009569	5594	Chemical	Gene	induces|nsubj|START_ENTITY induces|xcomp|heme_oxygenase-1 heme_oxygenase-1|dep|END_ENTITY	Nitric_oxide induces heme_oxygenase-1 via mitogen-activated protein kinases ERK and p38 .
12369731	0	Nitric_oxide	0,12	ERK	70,73	Nitric oxide	ERK	MESH:D009569	5594	Chemical	Gene	interferes|nsubj|START_ENTITY interferes|dobj|involvement involvement|nmod|END_ENTITY	Nitric_oxide interferes with salivary mucin synthesis : involvement of ERK and p38 mitogen-activated protein kinase .
12587977	0	Nitric_oxide	0,12	ERK	64,67	Nitric oxide	ERK	MESH:D009569	5594	Chemical	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Nitric_oxide as a modulator of gastric mucin synthesis : role of ERK and p38_mitogen-activated_protein_kinase activation .
21742048	0	Nitric_oxide	0,12	ERK	41,44	Nitric oxide	ERK	MESH:D009569	24338(Tax:10116)	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|END_ENTITY	Nitric_oxide promotes nicotine-triggered ERK signaling via redox reactions in PC12 cells .
23608617	0	Nitric_oxide	0,12	ERK	36,39	Nitric oxide	ERK	MESH:D009569	24338(Tax:10116)	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|END_ENTITY	Nitric_oxide differentially affects ERK and Akt in type 1 and type 2 diabetic rats .
16757573	0	Nitric_oxide	0,12	Erk1/2	27,33	Nitric oxide	Erk1/2	MESH:D009569	5595;5594	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Nitric_oxide activation of Erk1/2 regulates the stability and translation of mRNA transcripts containing CU-rich elements .
10650136	0	Nitric_oxide	0,12	Fos	110,113	Nitric oxide	Fos	MESH:D009569	314322(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY neurons|nsubj|synthase neurons|xcomp|expressing expressing|dobj|protein protein|compound|END_ENTITY	Nitric_oxide synthase and glutamate receptor immunoreactivity in the rat spinal trigeminal neurons expressing Fos protein after formalin injection .
1421085	0	Nitric_oxide	0,12	Fos	22,25	Nitric oxide	Fos	MESH:D009569	314322(Tax:10116)	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|dobj|expression expression|compound|END_ENTITY	Nitric_oxide mediates Fos expression in the spinal cord induced by mechanical noxious stimulation .
17666490	0	Nitric_oxide	0,12	GLUT4	23,28	Nitric oxide	GLUT4	MESH:D009569	25139(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Nitric_oxide increases GLUT4 expression and regulates AMPK signaling in skeletal muscle .
9344755	0	Nitric_oxide	0,12	ICAM-1	46,52	Nitric oxide	ICAM-1	MESH:D009569	25464(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|compound|END_ENTITY	Nitric_oxide attenuates reoxygenation-induced ICAM-1 expression in coronary microvascular endothelium : role of NFkappaB .
16002677	0	Nitric_oxide	0,12	IFN-alpha	22,31	Nitric oxide	IFN-alpha	MESH:D009569	3439	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Nitric_oxide inhibits IFN-alpha production of human plasmacytoid dendritic cells partly via a guanosine_3 ' ,5 ' - cyclic_monophosphate-dependent pathway .
7697730	0	Nitric_oxide	0,12	IFN-gamma	24,33	Nitric oxide	IFN-gamma	MESH:D009569	25712(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|production production|amod|END_ENTITY	Nitric_oxide suppresses IFN-gamma production in the spleen of mercuric_chloride-exposed brown Norway_rats .
19541350	0	Nitric_oxide	0,12	IFN_regulatory_factor_1	22,45	Nitric oxide	IFN regulatory factor 1	MESH:D009569	3659	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Nitric_oxide inhibits IFN_regulatory_factor_1 and nuclear factor-kappaB pathways in rhinovirus-infected epithelial cells .
12919881	0	Nitric_oxide	0,12	IGF-1	27,32	Nitric oxide	IGF-1	MESH:D009569	3479	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|synthesis synthesis|compound|END_ENTITY	Nitric_oxide inhibition of IGF-1 stimulated proteoglycan synthesis : role of cGMP .
11003576	0	Nitric_oxide	0,12	IGF-I	46,51	Nitric oxide	IGF-I	MESH:D009569	3479	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Nitric_oxide inhibits chondrocyte response to IGF-I : inhibition of IGF-IRbeta tyrosine phosphorylation .
19608980	0	Nitric_oxide	0,12	IK1	31,34	Nitric oxide	IK1	MESH:D009569	10320	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Nitric_oxide increases cardiac IK1 by nitrosylation of cysteine 76 of Kir2 .1 channels .
25434084	0	Nitric_oxide	1,13	IL-1b	30,35	Nitric oxide	IL-1b	MESH:D009569	24494(Tax:10116)	Chemical	Gene	mediated|nsubj|START_ENTITY mediated|dobj|expression expression|amod|END_ENTITY	-LSB- Nitric_oxide mediated TNF-a , IL-1b gene expression in liver induced by crush_injury of rat 's soft tissues -RSB- .
25507682	0	Nitric_oxide	1,13	IL-1b	30,35	Nitric oxide	IL-1b	MESH:D009569	24494(Tax:10116)	Chemical	Gene	mediated|nsubj|START_ENTITY mediated|dobj|expression expression|amod|END_ENTITY	-LSB- Nitric_oxide mediated TNF-a , IL-1b gene expression in liver induced by crush_injury of rat 's soft tissues -RSB- .
9712106	0	Nitric_oxide	0,12	IL-1beta	46,54	Nitric oxide	IL-1beta	MESH:D009569	3553	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	Nitric_oxide downregulates interleukin_1beta -LRB- IL-1beta -RRB- stimulated IL-6 , IL-8 , and prostaglandin_E2 production by human chondrocytes .
9780184	0	Nitric_oxide	0,12	IL-1beta	22,30	Nitric oxide	IL-1beta	MESH:D009569	16176(Tax:10090)	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|dobj|END_ENTITY	Nitric_oxide prevents IL-1beta and IFN-gamma-inducing_factor -LRB- IL-18 -RRB- release from macrophages by inhibiting caspase-1 -LRB- IL-1beta-converting_enzyme -RRB- .
21414799	0	Nitric_oxide	0,12	IL-6	21,25	Nitric oxide	IL-6	MESH:D009569	3569	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|expression expression|compound|END_ENTITY	Nitric_oxide affects IL-6 expression in human peripheral blood mononuclear cells involving cGMP-dependent modulation of NF-kB activity .
23183248	0	Nitric_oxide	0,12	IL-6	23,27	Nitric oxide	IL-6	MESH:D009569	3569	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|production production|compound|END_ENTITY	Nitric_oxide activates IL-6 production and expression in human renal epithelial cells .
7791330	0	Nitric_oxide	0,12	IL-6	34,38	Nitric oxide	IL-6	MESH:D009569	24498(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	Nitric_oxide inhibits LPS-induced IL-6 production in enterocytes .
9712106	0	Nitric_oxide	0,12	IL-6	67,71	Nitric oxide	IL-6	MESH:D009569	3569	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|IL-1beta IL-1beta|acl|stimulated stimulated|dobj|END_ENTITY	Nitric_oxide downregulates interleukin_1beta -LRB- IL-1beta -RRB- stimulated IL-6 , IL-8 , and prostaglandin_E2 production by human chondrocytes .
11399048	0	Nitric_oxide	0,12	IL-8	24,28	Nitric oxide	IL-8	MESH:D009569	20309(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|transcription transcription|compound|END_ENTITY	Nitric_oxide suppresses IL-8 transcription by inhibiting c-Jun N-terminal kinase-induced AP-1 activation .
15169673	0	Nitric_oxide	0,12	IL-8	23,27	Nitric oxide	IL-8	MESH:D009569	3576	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|transcription transcription|compound|END_ENTITY	Nitric_oxide increases IL-8 gene transcription and mRNA stability to enhance IL-8 gene expression in lung epithelial cells .
15169673	0	Nitric_oxide	0,12	IL-8	77,81	Nitric oxide	IL-8	MESH:D009569	3576	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|transcription transcription|acl|enhance enhance|dobj|expression expression|compound|END_ENTITY	Nitric_oxide increases IL-8 gene transcription and mRNA stability to enhance IL-8 gene expression in lung epithelial cells .
15178710	0	Nitric_oxide	0,12	IL-8	61,65	Nitric oxide	IL-8	MESH:D009569	3576	Chemical	Gene	post-transcriptionally|amod|START_ENTITY up-regulates|nsubj|post-transcriptionally up-regulates|dobj|expression expression|compound|END_ENTITY	Nitric_oxide post-transcriptionally up-regulates LPS-induced IL-8 expression through p38 MAPK activation .
7575568	0	Nitric_oxide	0,12	IL-8	23,27	Nitric oxide	IL-8	MESH:D009569	3576	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Nitric_oxide regulates IL-8 expression in melanoma cells at the transcriptional level .
7794282	0	Nitric_oxide	0,12	IL-8	27,31	Nitric oxide	IL-8	MESH:D009569	3576	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Nitric_oxide regulation of IL-8 expression in human endothelial cells .
18498724	0	Nitric_oxide	0,12	Jumonji	40,47	Nitric oxide	Jumonji	MESH:D009569	16468(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Nitric_oxide induces gene expression of Jumonji and retinoblastoma 2 protein while reducing expression of atrial natriuretic peptide precursor type B in cardiomyocytes .
14527174	0	Nitric_oxide	0,12	MCP-1	23,28	Nitric oxide	MCP-1	MESH:D009569	20296(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Nitric_oxide modulates MCP-1 expression in endothelial cells : implications for the pathogenesis of pulmonary_granulomatous_vasculitis .
21901758	0	Nitric_oxide	0,12	MCT4	71,75	Nitric oxide	MCT4	MESH:D009569	80879(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Nitric_oxide induces the expression of the monocarboxylate transporter MCT4 in cultured astrocytes by a cGMP-independent transcriptional activation .
10972089	0	Nitric_oxide	0,12	MIP-1alpha	23,33	Nitric oxide	MIP-1alpha	MESH:D009569	6348	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Nitric_oxide regulates MIP-1alpha expression in primary macrophages and T lymphocytes : implications for anti-HIV-1 response .
10846176	0	Nitric_oxide	0,12	MKP-3	28,33	Nitric oxide	MKP-3	MESH:D009569	1848	Chemical	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	Nitric_oxide down-regulates MKP-3 mRNA levels : involvement in endothelial cell protection from apoptosis .
18495757	0	Nitric_oxide	0,12	MMP-13	32,38	Nitric oxide	MMP-13	MESH:D009569	17386(Tax:10090)	Chemical	Gene	elicits|nsubj|START_ENTITY elicits|dobj|nitration nitration|amod|END_ENTITY	Nitric_oxide elicits functional MMP-13 protein-tyrosine nitration during wound repair .
16980554	0	Nitric_oxide	0,12	MMP-9	84,89	Nitric oxide	MMP-9	MESH:D009569	4318	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|activation activation|nmod|END_ENTITY	Nitric_oxide promotes airway epithelial wound repair through enhanced activation of MMP-9 .
22387196	0	Nitric_oxide	0,12	NADPH_oxidase_5	21,36	Nitric oxide	NADPH oxidase 5	MESH:D009569	79400	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|activity activity|amod|END_ENTITY	Nitric_oxide reduces NADPH_oxidase_5 -LRB- Nox5 -RRB- activity by reversible S-nitrosylation .
21159997	0	Nitric_oxide	0,12	NCX1	24,28	Nitric oxide	NCX1	MESH:D009569	6546	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Nitric_oxide stimulates NCX1 and NCX2 but inhibits NCX3 isoform by three distinct molecular determinants .
10393859	0	Nitric_oxide	0,12	NF-kappaB	38,47	Nitric oxide	NF-kappaB	MESH:D009569	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|HIV HIV|dobj|activation activation|amod|END_ENTITY	Nitric_oxide inhibits HIV tat-induced NF-kappaB activation .
10505790	0	Nitric_oxide	0,12	NF-kappaB	92,101	Nitric oxide	NF-kappaB	MESH:D009569	4790	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|advcl|inhibiting inhibiting|xcomp|binding binding|advmod|END_ENTITY	Nitric_oxide regulates interleukin-8 gene expression in activated endothelium by inhibiting NF-kappaB binding to DNA : effects on endothelial function .
14633657	0	Nitric_oxide	0,12	NF-kappaB	88,97	Nitric oxide	NF-kappaB	MESH:D009569	18033(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Nitric_oxide induces expression of cyclooxygenase-2 in mouse skin through activation of NF-kappaB .
19135070	0	Nitric_oxide	0,12	NF-kappaB	22,31	Nitric oxide	NF-kappaB	MESH:D009569	4790	Chemical	Gene	utilizes|amod|START_ENTITY END_ENTITY|nsubj|utilizes	Nitric_oxide utilizes NF-kappaB to signal its neuroprotective effect against alcohol_toxicity .
9065784	0	Nitric_oxide	0,12	NF-kappaB	77,86	Nitric oxide	NF-kappaB	MESH:D009569	4790	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|advcl|inhibiting inhibiting|xcomp|binding binding|advmod|END_ENTITY	Nitric_oxide regulates nitric_oxide synthase-2 gene expression by inhibiting NF-kappaB binding to DNA .
11849438	0	Nitric_oxide	0,12	NOS	48,51	Nitric oxide	NOS	MESH:D009569	4843	Chemical	Gene	START_ENTITY|dep|NOS NOS|nmod|END_ENTITY	Nitric_oxide in acute_renal_failure : NOS versus NOS .
16513480	0	Nitric_oxide	0,12	NOS	23,26	Nitric oxide	NOS	MESH:D009569	4842	Chemical	Gene	characterization|compound|START_ENTITY characterization|appos|END_ENTITY	Nitric_oxide synthase -LRB- NOS -RRB- characterization in Leishmania amazonensis axenic amastigotes .
16787174	0	Nitric_oxide	0,12	NOS	23,26	Nitric oxide	NOS	MESH:D009569	4842	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	Nitric_oxide synthase -LRB- NOS -RRB- as therapeutic target for asthma and chronic_obstructive_pulmonary_disease .
18980232	0	Nitric_oxide	0,12	NOS	23,26	Nitric oxide	NOS	MESH:D009569	4843	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	Nitric_oxide synthase -LRB- NOS -RRB- in the Japanese fireflies Luciola lateralis and Luciola cruciata .
21737361	1	Nitric_oxide	131,143	NOS	273,276	Nitric oxide	NOS	MESH:D009569	4843	Chemical	Gene	originates|nsubj|START_ENTITY originates|nmod|oxidation oxidation|nmod|L-arginine L-arginine|acl|catalysed catalysed|nmod|NO_synthase NO_synthase|appos|END_ENTITY	Nitric_oxide -LRB- NO -RRB- , the endogenous modulator of vascular tone and structure , originates from oxidation of L-arginine catalysed by NO_synthase -LRB- NOS -RRB- .
24076140	0	Nitric_oxide	0,12	NOS	23,26	Nitric oxide	NOS	MESH:D009569	4843	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	Nitric_oxide synthase -LRB- NOS -RRB- in the cyprid of Amphibalanus amphitrite -LRB- Cirripedia , Crustacea -RRB- .
7526585	0	Nitric_oxide	0,12	NOS	23,26	Nitric oxide	NOS	MESH:D009569	4843	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	Nitric_oxide synthase -LRB- NOS -RRB- in the human umbilical cord vessels .
8983811	3	Nitric_oxide	398,410	NOS	421,424	Nitric oxide	NOS	MESH:D009569	4843	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	NO is synthesised from L-arginine by a family of enzymes called Nitric_oxide synthase -LRB- NOS -RRB- .
9560472	0	Nitric_oxide	0,12	NOS	23,26	Nitric oxide	NOS	MESH:D009569	18125(Tax:10090)	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	Nitric_oxide synthase -LRB- NOS -RRB- in mouse skeletal muscle development and differentiated myoblasts .
10995553	0	Nitric_oxide	0,12	NOS-1	23,28	Nitric oxide	NOS-1	MESH:D009569	18125(Tax:10090)	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	Nitric_oxide synthase -LRB- NOS-1 -RRB- coclustered with agrin-induced AChR-specializations on cultured skeletal myotubes .
19923416	0	Nitric_oxide	0,12	NOS1	30,34	Nitric oxide	NOS1	MESH:D009569	24598(Tax:10116)	Chemical	Gene	originating|compound|START_ENTITY originating|nmod|END_ENTITY	Nitric_oxide originating from NOS1 controls oxygen utilization and electrolyte transport efficiency in the diabetic_kidney .
11509447	0	Nitric_oxide	0,12	NOS2	23,27	Nitric oxide	NOS2	MESH:D009569	24599(Tax:10116)	Chemical	Gene	mutation|compound|START_ENTITY mutation|appos|END_ENTITY	Nitric_oxide synthase -LRB- NOS2 -RRB- mutation in Dahl/Rapp rats decreases enzyme stability .
20953358	0	Nitric_oxide	0,12	NOS2	75,79	Nitric oxide	NOS2	MESH:D009569	18126(Tax:10090)	Chemical	Gene	enzymes|amod|START_ENTITY exposed|nsubj|enzymes exposed|parataxis|dependent dependent|nsubj|expression expression|compound|END_ENTITY	Nitric_oxide synthase enzymes in the airways of mice exposed to ovalbumin : NOS2 expression is NOS3 dependent .
21354308	0	Nitric_oxide	0,12	NOS2	79,83	Nitric oxide	NOS2	MESH:D009569	18126(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|parataxis|involvement involvement|nmod|END_ENTITY	Nitric_oxide regulates astrocyte maturation in the hippocampus : involvement of NOS2 .
20953358	0	Nitric_oxide	0,12	NOS3	94,98	Nitric oxide	NOS3	MESH:D009569	18127(Tax:10090)	Chemical	Gene	enzymes|amod|START_ENTITY exposed|nsubj|enzymes exposed|parataxis|dependent dependent|advmod|END_ENTITY	Nitric_oxide synthase enzymes in the airways of mice exposed to ovalbumin : NOS2 expression is NOS3 dependent .
8621775	0	Nitric_oxide	0,12	NOS3	23,27	Nitric oxide	NOS3	MESH:D009569	24600(Tax:10116)	Chemical	Gene	synthase|advmod|START_ENTITY synthase|dep|END_ENTITY	Nitric_oxide synthase -LRB- NOS3 -RRB- and contractile responsiveness to adrenergic and cholinergic agonists in the heart .
16254042	0	Nitric_oxide	0,12	Nox1	82,86	Nitric oxide	Nox1	MESH:D009569	114243(Tax:10116)	Chemical	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|nmod|END_ENTITY	Nitric_oxide down-regulates the expression of the catalytic NADPH oxidase subunit Nox1 in rat renal mesangial cells .
12878207	0	Nitric_oxide	0,12	Nrf2	24,28	Nitric oxide	Nrf2	MESH:D009569	4780	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|translocation translocation|amod|END_ENTITY	Nitric_oxide stimulates Nrf2 nuclear translocation in vascular endothelium .
21703357	0	Nitric_oxide	0,12	Nrf2	23,27	Nitric oxide	Nrf2	MESH:D009569	83619(Tax:10116)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Nitric_oxide activates Nrf2 through S-nitrosylation of Keap1 in PC12 cells .
9489510	0	Nitric_oxide	0,12	Oct-1	22,27	Nitric oxide	Oct-1	MESH:D009569	24904(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Nitric_oxide inhibits Oct-1 DNA binding activity in cultured vascular smooth muscle cells .
18616941	0	Nitric_oxide	0,12	Oct-4	22,27	Nitric oxide	Oct-4	MESH:D009569	100846986	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	Nitric_oxide enhances Oct-4 expression in bone marrow stem cells and promotes endothelial differentiation .
9683440	0	Nitric_oxide	0,12	P-selectin	56,66	Nitric oxide	P-selectin	MESH:D009569	6403	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|xcomp|gut gut|dobj|expression expression|amod|END_ENTITY	Nitric_oxide modulates gut ischemia-reperfusion-induced P-selectin expression in murine liver .
20643772	0	Nitric_oxide	0,12	PGC-1	45,50	Nitric oxide	PGC-1	MESH:D009569	19017(Tax:10090)	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	Nitric_oxide and AMPK cooperatively regulate PGC-1 in skeletal muscle cells .
15313192	0	Nitric_oxide	0,12	Rap1	23,27	Nitric oxide	Rap1	MESH:D009569	5906	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Nitric_oxide activates Rap1 and Ral in a Ras-independent manner .
16963453	0	Nitric_oxide	0,12	Rap1	120,124	Nitric oxide	Rap1	MESH:D009569	5906	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Nitric_oxide produced in response to engagement of beta2 integrins on human neutrophils activates the monomeric GTPases Rap1 and Rap2 and promotes adhesion .
17891653	0	Nitric_oxide	0,12	S100B	87,92	Nitric oxide	S100B	MESH:D009569	6285	Chemical	Gene	test|amod|START_ENTITY decreases|nsubj|test decreases|dobj|concentrations concentrations|nmod|protein protein|nummod|END_ENTITY	Nitric_oxide test during cardiac catheterization decreases the serum concentrations of S100B protein in adult patients with idiopathic_pulmonary_hypertension .
17059693	0	Nitric_oxide	0,12	SOCS-1	21,27	Nitric oxide	SOCS-1	MESH:D009569	8651	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Nitric_oxide induces SOCS-1 expression in human monocytes in a TNF-alpha-dependent manner .
19578009	0	Nitric_oxide	0,12	TGF-beta	33,41	Nitric oxide	TGF-beta	MESH:D009569	59086(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|signaling signaling|compound|END_ENTITY	Nitric_oxide inhibits glomerular TGF-beta signaling via SMOC-1 .
16183640	0	Nitric_oxide	0,12	TIMP-1	21,27	Nitric oxide	TIMP-1	MESH:D009569	7076	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Nitric_oxide induces TIMP-1 expression by activating the transforming_growth_factor_beta-Smad signaling pathway .
25434084	0	Nitric_oxide	1,13	TNF-a	23,28	Nitric oxide	TNF-a	MESH:D009569	24835(Tax:10116)	Chemical	Gene	mediated|nsubj|START_ENTITY mediated|dobj|expression expression|amod|END_ENTITY	-LSB- Nitric_oxide mediated TNF-a , IL-1b gene expression in liver induced by crush_injury of rat 's soft tissues -RSB- .
25507682	0	Nitric_oxide	1,13	TNF-a	23,28	Nitric oxide	TNF-a	MESH:D009569	24835(Tax:10116)	Chemical	Gene	mediated|nsubj|START_ENTITY mediated|dobj|expression expression|amod|END_ENTITY	-LSB- Nitric_oxide mediated TNF-a , IL-1b gene expression in liver induced by crush_injury of rat 's soft tissues -RSB- .
15275867	0	Nitric_oxide	0,12	TNF-alpha	67,76	Nitric oxide	TNF-alpha	MESH:D009569	7124	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|nmod|IRAK-M IRAK-M|nmod|release release|nmod|END_ENTITY	Nitric_oxide activates the expression of IRAK-M via the release of TNF-alpha in human monocytes .
1656767	0	Nitric_oxide	0,12	TNF-alpha	81,90	Nitric oxide	TNF-alpha	MESH:D009569	280943(Tax:9913)	Chemical	Gene	synthesis|amod|START_ENTITY synthesis|dep|evidence evidence|nmod|inducible inducible|nmod|END_ENTITY	Nitric_oxide synthesis in endothelial cells : evidence for a pathway inducible by TNF-alpha .
17923423	0	Nitric_oxide	0,12	TNF-alpha	73,82	Nitric oxide	TNF-alpha	MESH:D009569	280943(Tax:9913)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|treatment treatment|amod|aggrecanase aggrecanase|nmod|END_ENTITY	Nitric_oxide enhances aggrecan degradation by aggrecanase in response to TNF-alpha but not IL-1beta treatment at a post-transcriptional level in bovine cartilage explants .
18824875	0	Nitric_oxide	0,12	TNF-alpha	28,37	Nitric oxide	TNF-alpha	MESH:D009569	7124	Chemical	Gene	involvement|amod|START_ENTITY involvement|nmod|END_ENTITY	Nitric_oxide involvement in TNF-alpha and IL-1_beta-mediated changes in human mesangial cell MMP-9 and TIMP-1 .
8144975	0	Nitric_oxide	0,12	TNF-alpha	41,50	Nitric oxide	TNF-alpha	MESH:D009569	7124	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|amod|END_ENTITY	Nitric_oxide regulates endotoxin-induced TNF-alpha production by human neutrophils .
11095525	0	Nitric_oxide	0,12	TrkB	27,31	Nitric oxide	TrkB	MESH:D009569	18212(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|activation activation|nmod|END_ENTITY	Nitric_oxide activation of TrkB through peroxynitrite .
8840861	1	Nitric_oxide	46,58	VCAM-1	93,99	Nitric oxide	VCAM-1	MESH:D009569	7412	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Nitric_oxide and transcriptional regulation of VCAM-1 .
12705893	0	Nitric_oxide	0,12	VE-cadherin	22,33	Nitric oxide	VE-cadherin	MESH:D009569	12562(Tax:10090)	Chemical	Gene	disrupts|nsubj|START_ENTITY disrupts|dobj|complex complex|amod|END_ENTITY	Nitric_oxide disrupts VE-cadherin complex in murine microvascular endothelial cells .
8769777	0	Nitric_oxide	0,12	VEGF	42,46	Nitric oxide	VEGF	MESH:D009569	7422	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|dobj|effect effect|nmod|END_ENTITY	Nitric_oxide mediates mitogenic effect of VEGF on coronary venular endothelium .
11418634	0	Nitric_oxide	0,12	Yin-Yang_1	50,60	Nitric oxide	Yin-Yang 1	MESH:D009569	7528	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	Nitric_oxide inhibits the transcription repressor Yin-Yang_1 binding activity at the silencer region of the Fas promoter : a pivotal role for nitric_oxide in the up-regulation of Fas gene expression in human tumor cells .
16329160	0	Nitric_oxide	0,12	adenosine_deaminase	14,33	Nitric oxide	adenosine deaminase	MESH:D009569	100	Chemical	Gene	oxidase|amod|START_ENTITY oxidase|amod|END_ENTITY	Nitric_oxide , adenosine_deaminase , xanthine oxidase and superoxide_dismutase in patients with panic_disorder : alterations by antidepressant treatment .
11834889	0	Nitric_oxide	0,12	adrenomedullin	24,38	Nitric oxide	adrenomedullin	MESH:D009569	133	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|compound|END_ENTITY	Nitric_oxide stimulates adrenomedullin secretion and gene expression in endothelial cells .
11967020	0	Nitric_oxide	0,12	adrenomedullin	23,37	Nitric oxide	adrenomedullin	MESH:D009569	25026(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|function function|compound|END_ENTITY	Nitric_oxide increases adrenomedullin receptor function in rat mesangial cells .
19714395	0	Nitric_oxide	0,12	adrenomedullin	69,83	Nitric oxide	adrenomedullin	MESH:D009569	11535(Tax:10090)	Chemical	Gene	START_ENTITY|parataxis|mediates mediates|dobj|action action|nmod|END_ENTITY	Nitric_oxide / cGMP signalling mediates the cardioprotective action of adrenomedullin in reperfused myocardium .
24093618	0	Nitric_oxide	0,12	alcohol_dehydrogenase	27,48	Nitric oxide	alcohol dehydrogenase	MESH:D009569	10327	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Nitric_oxide inhibition of alcohol_dehydrogenase in fresh-cut apples -LRB- Malus domestica Borkh -RRB- .
12355151	0	Nitric_oxide	0,12	alternative_oxidase	77,96	Nitric oxide	alternative oxidase	MESH:D009569	836542(Tax:3702)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|nmod|END_ENTITY	Nitric_oxide induces transcriptional activation of the nitric_oxide-tolerant alternative_oxidase in Arabidopsis suspension cells .
12937782	0	Nitric_oxide	0,12	angiotensin-I_converting_enzyme	23,54	Nitric oxide	angiotensin-I converting enzyme	MESH:D009569	100009274(Tax:9986)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Nitric_oxide regulates angiotensin-I_converting_enzyme under static conditions but not under shear stress .
7769810	0	Nitric_oxide	0,12	angiotensin-converting_enzyme	71,100	Nitric oxide	angiotensin-converting enzyme	MESH:D009569	100715217	Chemical	Gene	accounts|amod|START_ENTITY accounts|nmod|cardioprotection cardioprotection|acl|resulting resulting|nmod|inhibition inhibition|amod|END_ENTITY	Nitric_oxide accounts for postischemic cardioprotection resulting from angiotensin-converting_enzyme inhibition : indirect evidence for a radical scavenger effect in isolated guinea_pig heart .
10671813	0	Nitric_oxide	0,12	angiotensin_II	21,35	Nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|response response|amod|END_ENTITY	Nitric_oxide affects angiotensin_II pressor response : possible mechanism of attenuated pressor response during pregnancy and etiology of pregnancy-induced hypertension .
10860637	0	Nitric_oxide	0,12	angiotensin_II	60,74	Nitric oxide	angiotensin II	MESH:D009569	11847(Tax:10090)	Chemical	Gene	induced|nsubj|START_ENTITY induced|nmod|END_ENTITY	Nitric_oxide and prostanoid-dependent relaxation induced by angiotensin_II in the isolated precontracted mouse tracheal muscle and the role of potassium channels .
10928298	0	Nitric_oxide	0,12	angiotensin_II	14,28	Nitric oxide	angiotensin II	MESH:D009569	183	Chemical	Gene	START_ENTITY|dep|axis axis|amod|END_ENTITY	Nitric_oxide -- angiotensin_II axis in renal_and_cardiovascular_injury .
11702851	0	Nitric_oxide	0,12	angiotensin_II	68,82	Nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	levels|amod|START_ENTITY correlate|nsubj|levels correlate|nmod|expression expression|nmod|receptors receptors|amod|END_ENTITY	Nitric_oxide synthase mRNA levels correlate with gene expression of angiotensin_II type-1 but not type-2 receptors , renin or angiotensin converting enzyme in selected brain areas .
11941405	0	Nitric_oxide	0,12	angiotensin_II	72,86	Nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|proto-oncogene_c-fos proto-oncogene_c-fos|dep|induced induced|nmod|END_ENTITY	Nitric_oxide inhibits the expression of proto-oncogene_c-fos induced by angiotensin_II and endothelin-1 in cardiomyocytes .
12480559	0	Nitric_oxide	0,12	angiotensin_II	62,76	Nitric oxide	angiotensin II	MESH:D009569	183	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Nitric_oxide mediates the reduced vasoconstrictor response to angiotensin_II in patients with preascitic cirrhosis .
12534362	0	Nitric_oxide	0,12	angiotensin_II	75,89	Nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|production production|nmod|inositol_phosphates inositol_phosphates|acl|stimulated stimulated|nmod|END_ENTITY	Nitric_oxide decreases the production of inositol_phosphates stimulated by angiotensin_II and thyrotropin-releasing_hormone in anterior pituitary cells .
15110897	0	Nitric_oxide	0,12	angiotensin_II	78,92	Nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	inhibition|amod|START_ENTITY accelerates|nsubj|inhibition accelerates|nmod|END_ENTITY	Nitric_oxide synthase inhibition accelerates the pressor response to low-dose angiotensin_II , exacerbates target organ damage , and induces renin escape .
15283756	0	Nitric_oxide	0,12	angiotensin_II	25,39	Nitric oxide	angiotensin II	MESH:D009569	11606(Tax:10090)	Chemical	Gene	counteracts|nsubj|START_ENTITY counteracts|dobj|END_ENTITY	Nitric_oxide counteracts angiotensin_II induced contraction in efferent arterioles in mice .
17959957	0	Nitric_oxide	0,12	angiotensin_II	72,86	Nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY mediate|nsubj|receptors mediate|dobj|effect effect|nmod|END_ENTITY	Nitric_oxide and angiotensin_II receptors mediate the pressor effect of angiotensin_II : a study in conscious and zoletil-anesthetized rats .
21210749	0	Nitric_oxide	0,12	angiotensin_II	37,51	Nitric oxide	angiotensin II	MESH:D009569	183	Chemical	Gene	modulates|amod|START_ENTITY reactivity|nsubj|modulates reactivity|nmod|END_ENTITY	Nitric_oxide modulates reactivity to angiotensin_II in internal mammary arterial grafts in hypertensive patients without associated risk factors .
7536678	0	Nitric_oxide	0,12	angiotensin_II	23,37	Nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|receptors receptors|amod|END_ENTITY	Nitric_oxide regulates angiotensin_II receptors in vascular smooth muscle cells .
8544396	0	Nitric_oxide	0,12	angiotensin_II	40,54	Nitric oxide	angiotensin II	MESH:D009569	183	Chemical	Gene	antagonizes|nsubj|START_ENTITY antagonizes|dobj|actions actions|nmod|END_ENTITY	Nitric_oxide antagonizes the actions of angiotensin_II to enhance tubuloglomerular feedback responsiveness .
8780230	0	Nitric_oxide	0,12	angiotensin_II	23,37	Nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|vasoconstriction vasoconstriction|amod|END_ENTITY	Nitric_oxide modulates angiotensin_II - and norepinephrine-dependent vasoconstriction in rat kidney .
9407461	0	Nitric_oxide	0,12	angiotensin_II	78,92	Nitric oxide	angiotensin II	MESH:D009569	183	Chemical	Gene	immunoreactivity|amod|START_ENTITY dependent|nsubj|immunoreactivity dependent|advmod|END_ENTITY	Nitric_oxide synthase I immunoreactivity in the macula densa of the kidney is angiotensin_II dependent .
9830056	0	Nitric_oxide	0,12	angiotensin_II	97,111	Nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|nmod|END_ENTITY	Nitric_oxide and N-acetylcysteine inhibit the activation of mitogen-activated protein kinases by angiotensin_II in rat cardiac fibroblasts .
9888514	0	Nitric_oxide	0,12	angiotensin_II	63,77	Nitric oxide	angiotensin II	MESH:D009569	11606(Tax:10090)	Chemical	Gene	involved|advmod|START_ENTITY involved|nmod|action action|nmod|END_ENTITY	Nitric_oxide , a new second messenger involved in the action of angiotensin_II on neuronal differentiation of NG108-15 cells .
10052722	0	Nitric_oxide	0,12	bFGF	24,28	Nitric oxide	bFGF	MESH:D009569	2247	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	Nitric_oxide suppresses bFGF - and IL-1-alpha-mediated but not VEGF165-mediated angiogenesis in natively vascularized mammalian tissue .
15942127	0	Nitric_oxide	0,12	bradykinin	26,36	Nitric oxide	bradykinin	MESH:D009569	478666(Tax:9615)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|amod|END_ENTITY	Nitric_oxide inhibits the bradykinin B2 receptor-mediated adrenomedullary catecholamine release but has no effect on adrenal blood flow response in vivo .
21892689	0	Nitric_oxide	0,12	c-Fos	24,29	Nitric oxide	c-Fos	MESH:D009569	314322(Tax:10116)	Chemical	Gene	implicates|nsubj|START_ENTITY implicates|dobj|expression expression|amod|END_ENTITY	Nitric_oxide implicates c-Fos expression in the cuneate nucleus following electrical stimulation of the transected median nerve .
9647775	0	Nitric_oxide	0,12	c-Jun_N-terminal_kinase_2	22,47	Nitric oxide	c-Jun N-terminal kinase 2	MESH:D009569	5601	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Nitric_oxide inhibits c-Jun_N-terminal_kinase_2 -LRB- JNK2 -RRB- via S-nitrosylation .
14742673	0	Nitric_oxide	0,12	c-fos	23,28	Nitric oxide	c-fos	MESH:D009569	314322(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Nitric_oxide regulates c-fos expression in nucleus tractus solitarii induced by baroreceptor activation via cGMP-dependent protein kinase and cAMP response element-binding protein phosphorylation .
17063538	0	Nitric_oxide	1,13	c-fos	24,29	Nitric oxide	c-fos	MESH:D009569	314322(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	-LSB- Nitric_oxide regulates c-fos expression in osteoblastic cells induced by wall-shear -RSB- .
8574661	0	Nitric_oxide	0,12	c-fos	21,26	Nitric oxide	c-fos	MESH:D009569	314322(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Nitric_oxide induces c-fos gene expression via cyclic_AMP_response_element_binding_protein -LRB- CREB -RRB- phosphorylation in rat retinal_pigment_epithelium .
16630053	0	Nitric_oxide	0,12	calcitonin_gene-related_peptide	27,58	Nitric oxide	calcitonin gene-related peptide	MESH:D009569	24241(Tax:10116)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Nitric_oxide regulation of calcitonin_gene-related_peptide gene expression in rat trigeminal ganglia neurons .
16847357	0	Nitric_oxide	0,12	calcitonin_gene-related_peptide	96,127	Nitric oxide	calcitonin gene-related peptide	MESH:D009569	24241(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY contributes|nsubj|activity contributes|xcomp|mucin mucin|dobj|synthesis synthesis|acl|elicited elicited|nmod|END_ENTITY	Nitric_oxide synthase activity in rat gastric mucosa contributes to mucin synthesis elicited by calcitonin_gene-related_peptide .
10066732	0	Nitric_oxide	0,12	caspase-3	22,31	Nitric oxide	caspase-3	MESH:D009569	836	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Nitric_oxide inhibits caspase-3 by S-nitrosation in vivo .
11454065	0	Nitric_oxide	0,12	caspase-3	98,107	Nitric oxide	caspase-3	MESH:D009569	836	Chemical	Gene	protects|nsubj|START_ENTITY protects|advcl|inhibiting inhibiting|xcomp|END_ENTITY	Nitric_oxide protects cultured rheumatoid synovial cells from Fas-induced apoptosis by inhibiting caspase-3 .
15623433	0	Nitric_oxide	0,12	caspase-3	57,66	Nitric oxide	caspase-3	MESH:D009569	836	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|preventing preventing|dobj|activity activity|amod|END_ENTITY	Nitric_oxide inhibits myocardial_apoptosis by preventing caspase-3 activity via S-nitrosylation .
16352744	0	Nitric_oxide	0,12	caspase-8	87,96	Nitric oxide	caspase-8	MESH:D009569	12370(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Nitric_oxide induces apoptosis in renal tubular_epithelial_cells through activation of caspase-8 .
16585560	0	Nitric_oxide	0,12	catalase	104,112	Nitric oxide	catalase	MESH:D009569	12359(Tax:10090)	Chemical	Gene	protects|nsubj|START_ENTITY protects|advcl|inducing inducing|dobj|formation formation|nmod|END_ENTITY	Nitric_oxide protects macrophages from hydrogen_peroxide-induced apoptosis by inducing the formation of catalase .
8945907	0	Nitric_oxide	0,12	catalase	39,47	Nitric oxide	catalase	MESH:D009569	531682(Tax:9913)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Nitric_oxide inhibits pulmonary artery catalase and H2O2-associated relaxation .
15064242	0	Nitric_oxide	0,12	caveolin-1_and_matrix_metalloproteinase-9	23,64	Nitric oxide	caveolin-1 and matrix metalloproteinase-9	MESH:D009569	857;4318	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	Nitric_oxide modulates caveolin-1_and_matrix_metalloproteinase-9 expression and distribution at the endothelial cell/tumor cell interface .
17519233	0	Nitric_oxide	0,12	caveolin-3	28,38	Nitric oxide	caveolin-3	MESH:D009569	859	Chemical	Gene	START_ENTITY|dobj|levels levels|amod|END_ENTITY	Nitric_oxide down-regulates caveolin-3 levels through the interaction with myogenin , its transcription factor .
12110001	0	Nitric_oxide	0,12	connective_tissue_growth_factor	28,59	Nitric oxide	connective tissue growth factor	MESH:D009569	64032(Tax:10116)	Chemical	Gene	down-regulates|amod|START_ENTITY END_ENTITY|nsubj|down-regulates	Nitric_oxide down-regulates connective_tissue_growth_factor in rat mesangial cells .
18280762	0	Nitric_oxide	0,12	corticotropin-releasing_hormone	70,101	Nitric oxide	corticotropin-releasing hormone	MESH:D009569	1392	Chemical	Gene	inhibitor|amod|START_ENTITY attenuates|nsubj|inhibitor attenuates|dobj|effect effect|nmod|END_ENTITY	Nitric_oxide synthase inhibitor attenuates the anorexigenic effect of corticotropin-releasing_hormone in neonatal chicks .
8481768	0	Nitric_oxide	0,12	corticotropin-releasing_hormone	38,69	Nitric oxide	corticotropin-releasing hormone	MESH:D009569	81648(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|release release|nmod|hypothalamus hypothalamus|amod|END_ENTITY	Nitric_oxide modulates the release of corticotropin-releasing_hormone from the rat hypothalamus in vitro .
8636301	0	Nitric_oxide	0,12	corticotropin-releasing_hormone	27,58	Nitric oxide	corticotropin-releasing hormone	MESH:D009569	1392	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|release release|amod|END_ENTITY	Nitric_oxide regulation of corticotropin-releasing_hormone release from the human perfused placenta in vitro .
10894794	0	Nitric_oxide	0,12	cyclooxygenase-2	38,54	Nitric oxide	cyclooxygenase-2	MESH:D009569	29527(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Nitric_oxide regulates renal cortical cyclooxygenase-2 expression .
12384172	0	Nitric_oxide	0,12	cyclooxygenase-2	80,96	Nitric oxide	cyclooxygenase-2	MESH:D009569	29527(Tax:10116)	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|increase increase|nmod|levels levels|amod|END_ENTITY	Nitric_oxide synergistically potentiates interleukin-1_beta-induced increase of cyclooxygenase-2 mRNA levels , resulting in the facilitation of substance P release from primary afferent neurons : involvement of cGMP-independent mechanisms .
14633657	0	Nitric_oxide	0,12	cyclooxygenase-2	35,51	Nitric oxide	cyclooxygenase-2	MESH:D009569	19225(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Nitric_oxide induces expression of cyclooxygenase-2 in mouse skin through activation of NF-kappaB .
16007171	0	Nitric_oxide	0,12	cyclooxygenase-2	29,45	Nitric oxide	cyclooxygenase-2	MESH:D009569	5743	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Nitric_oxide upregulates the cyclooxygenase-2 expression through the cAMP-response element in its promoter in several cancer cell lines .
16380459	0	Nitric_oxide	0,12	cyclooxygenase-2	24,40	Nitric oxide	cyclooxygenase-2	MESH:D009569	19225(Tax:10090)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|xcomp|END_ENTITY	Nitric_oxide stimulates cyclooxygenase-2 in cultured cTAL cells through a p38-dependent pathway .
20660237	0	Nitric_oxide	0,12	cyclooxygenase-2	24,40	Nitric oxide	cyclooxygenase-2	MESH:D009569	5743	Chemical	Gene	synthases|amod|START_ENTITY synthases|amod|END_ENTITY	Nitric_oxide synthases , cyclooxygenase-2 , nitrotyrosine , and angiogenesis in chondrosarcoma and their relation to prognosis .
8621794	0	Nitric_oxide	0,12	cyclooxygenase-2	45,61	Nitric oxide	cyclooxygenase-2	MESH:D009569	29527(Tax:10116)	Chemical	Gene	amplifies|nsubj|START_ENTITY amplifies|dobj|expression expression|amod|END_ENTITY	Nitric_oxide amplifies interleukin 1-induced cyclooxygenase-2 expression in rat mesangial cells .
11741289	0	Nitric_oxide	0,12	cytochrome_B	36,48	Nitric oxide	cytochrome B	MESH:D009569	17711(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Nitric_oxide inhibits expression of cytochrome_B in endotoxin-stimulated murine macrophages .
11912135	0	Nitric_oxide	0,12	cytochrome_C	46,58	Nitric oxide	cytochrome C	MESH:D009569	54205	Chemical	Gene	inhibits|compound|START_ENTITY apoptosis|nsubj|inhibits apoptosis|dobj|downstream downstream|nmod|release release|amod|END_ENTITY	Nitric_oxide inhibits apoptosis downstream of cytochrome_C release by nitrosylating caspase_9 .
22803508	0	Nitric_oxide	0,12	cytochrome_C	58,70	Nitric oxide	cytochrome C	MESH:D009569	54205	Chemical	Gene	START_ENTITY|xcomp|binding binding|nmod|complex complex|nmod|END_ENTITY	Nitric_oxide binding to the cardiolipin complex of ferric cytochrome_C .
11396931	0	Nitric_oxide	0,12	cytochrome_P450_2E1	89,108	Nitric oxide	cytochrome P450 2E1	MESH:D009569	25086(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Nitric_oxide from the inducible_nitric_oxide_synthase -LRB- iNOS -RRB- increases the expression of cytochrome_P450_2E1 in iNOS-null hepatocytes in the absence of inflammatory stimuli .
10222263	0	Nitric_oxide	0,12	cytochrome_c	122,134	Nitric oxide	cytochrome c	MESH:D009569	54205	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|execution execution|nmod|release release|amod|END_ENTITY	Nitric_oxide inhibits execution of apoptosis at two distinct ATP-dependent steps upstream and downstream of mitochondrial cytochrome_c release .
10593878	0	Nitric_oxide	0,12	cytochrome_c	55,67	Nitric oxide	cytochrome c	MESH:D009569	54205	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|nitration nitration|nmod|END_ENTITY	Nitric_oxide induces tyrosine nitration and release of cytochrome_c preceding an increase of mitochondrial transmembrane potential in macrophages .
15913362	0	Nitric_oxide	0,12	cytochrome_c	30,42	Nitric oxide	cytochrome c	MESH:D009569	54205	Chemical	Gene	interaction|nsubj|START_ENTITY interaction|nmod|END_ENTITY	Nitric_oxide interaction with cytochrome_c ' and its relevance to guanylate cyclase .
16543234	0	Nitric_oxide	0,12	cytochrome_c	45,57	Nitric oxide	cytochrome c	MESH:D009569	54205	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	Nitric_oxide inhibits peroxidase activity of cytochrome_c .
12466224	0	Nitric_oxide	0,12	dopamine_transporter	144,164	Nitric oxide	dopamine transporter	MESH:D009569	6531	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|expressing expressing|dobj|END_ENTITY	Nitric_oxide inhibits uptake of dopamine and N-methyl-4-phenylpyridinium -LRB- MPP + -RRB- but not release of MPP + in rat C6 glioma cells expressing human dopamine_transporter .
7523382	0	Nitric_oxide	0,12	early_growth_response-1	21,44	Nitric oxide	early growth response-1	MESH:D009569	24330(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|amod|END_ENTITY	Nitric_oxide reduces early_growth_response-1 gene expression in rat lung macrophages treated with interferon-gamma and lipopolysaccharide .
11379760	0	Nitric_oxide	0,12	elastin	24,31	Nitric oxide	elastin	MESH:D009569	396441(Tax:9031)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	Nitric_oxide stimulates elastin expression in chick aortic smooth muscle cells .
12352363	0	Nitric_oxide	0,12	endothelial_nitric_oxide_synthase	46,79	Nitric oxide	endothelial nitric oxide synthase	MESH:D009569	18127(Tax:10090)	Chemical	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Nitric_oxide in obstructive uropathy : role of endothelial_nitric_oxide_synthase .
10051125	0	Nitric_oxide	0,12	endothelin-1	92,104	Nitric oxide	endothelin-1	MESH:D009569	100726197	Chemical	Gene	limits|nsubj|START_ENTITY limits|dobj|bronchoconstriction bronchoconstriction|acl|induced induced|nmod|END_ENTITY	Nitric_oxide limits the eicosanoid-dependent bronchoconstriction and hypotension induced by endothelin-1 in the guinea-pig .
10378824	0	Nitric_oxide	0,12	endothelin-1	21,33	Nitric oxide	endothelin-1	MESH:D009569	24323(Tax:10116)	Chemical	Gene	impacts|nsubj|START_ENTITY impacts|dobj|expression expression|amod|END_ENTITY	Nitric_oxide impacts endothelin-1 gene expression in intrapulmonary arteries of chronically hypoxic rats .
11078352	0	Nitric_oxide	0,12	endothelin-1	65,77	Nitric oxide	endothelin-1	MESH:D009569	100009270(Tax:9986)	Chemical	Gene	relaxes|nsubj|START_ENTITY relaxes|dobj|muscle muscle|nmod|increase increase|amod|END_ENTITY	Nitric_oxide relaxes the vascular smooth muscle independently of endothelin-1 - and U46619-induced intracellular increase of calcium .
11814459	0	Nitric_oxide	0,12	endothelin-1	13,25	Nitric oxide	endothelin-1	MESH:D009569	1906	Chemical	Gene	/|nsubj|START_ENTITY /|xcomp|END_ENTITY	Nitric_oxide / endothelin-1 in preeclampsia .
11890739	0	Nitric_oxide	0,12	endothelin-1	27,39	Nitric oxide	endothelin-1	MESH:D009569	281137(Tax:9913)	Chemical	Gene	gas|amod|START_ENTITY decreases|nsubj|gas decreases|dobj|mRNA mRNA|amod|END_ENTITY	Nitric_oxide gas decreases endothelin-1 mRNA in cultured pulmonary artery endothelial cells .
12193057	0	Nitric_oxide	0,12	endothelin-1	22,34	Nitric oxide	endothelin-1	MESH:D009569	24323(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Nitric_oxide inhibits endothelin-1 production through the suppression of nuclear factor kappa B .
14695117	0	Nitric_oxide	0,12	endothelin-1	23,35	Nitric oxide	endothelin-1	MESH:D009569	1906	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|secretion secretion|amod|END_ENTITY	Nitric_oxide decreases endothelin-1 secretion through the activation of soluble guanylate cyclase .
15838347	0	Nitric_oxide	0,12	endothelin-1	92,104	Nitric oxide	endothelin-1	MESH:D009569	24323(Tax:10116)	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|suppression suppression|nmod|overproduction overproduction|amod|END_ENTITY	Nitric_oxide protects against ischemic acute_renal_failure through the suppression of renal endothelin-1 overproduction .
15838368	0	Nitric_oxide	0,12	endothelin-1	34,46	Nitric oxide	endothelin-1	MESH:D009569	1906	Chemical	Gene	inhalation|amod|START_ENTITY modulates|nsubj|inhalation modulates|ccomp|assist assist|nsubj|gradients gradients|amod|END_ENTITY	Nitric_oxide inhalation modulates endothelin-1 plasma concentration gradients following left ventricular assist device implantation .
16133050	0	Nitric_oxide	0,12	endothelin-1	55,67	Nitric oxide	endothelin-1	MESH:D009569	100294653(Tax:9940)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|effect effect|nmod|END_ENTITY	Nitric_oxide modulates renal vasoconstrictor effect of endothelin-1 in conscious lambs .
17041684	0	Nitric_oxide	0,12	endothelin-1	14,26	Nitric oxide	endothelin-1	MESH:D009569	1906	Chemical	Gene	grafts|advmod|START_ENTITY grafts|nsubj|production production|amod|END_ENTITY	Nitric_oxide , endothelin-1 , and superoxide production in arterial bypass grafts .
17552879	0	Nitric_oxide	0,12	endothelin-1	55,67	Nitric oxide	endothelin-1	MESH:D009569	100009270(Tax:9986)	Chemical	Gene	START_ENTITY|dep|players players|nmod|myocardial_distensibility myocardial_distensibility|amod|END_ENTITY	Nitric_oxide and prostaglandins - important players in endothelin-1 induced myocardial_distensibility .
21660948	0	Nitric_oxide	0,12	endothelin-1	27,39	Nitric oxide	endothelin-1	MESH:D009569	24323(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Nitric_oxide production by endothelin-1 enhances astrocytic migration via the tyrosine nitration of matrix_metalloproteinase-9 .
9087662	0	Nitric_oxide	0,12	endothelin-1	75,87	Nitric oxide	endothelin-1	MESH:D009569	24323(Tax:10116)	Chemical	Gene	inhibition|amod|START_ENTITY reverses|nsubj|inhibition reverses|nmod|END_ENTITY	Nitric_oxide synthase inhibition reverses arteriolar hyporesponsiveness to endothelin-1 in septic rats .
9806815	0	Nitric_oxide	0,12	endothelin-1	70,82	Nitric oxide	endothelin-1	MESH:D009569	24323(Tax:10116)	Chemical	Gene	synthesis|compound|START_ENTITY affect|nsubj|synthesis affect|dobj|responses responses|acl|induced induced|advcl|END_ENTITY	Nitric_oxide synthesis does not affect depressor responses induced by endothelin-1 into the superior colliculus of rats .
25226840	0	Nitric_oxide	0,12	endothelin_converting_enzyme-1	48,78	Nitric oxide	endothelin converting enzyme-1	MESH:D009569	1889	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|nmod|END_ENTITY	Nitric_oxide inhibits the production of soluble endothelin_converting_enzyme-1 .
15202319	0	Nitric_oxide	1,13	erythropoietin	114,128	Nitric oxide	erythropoietin	MESH:D009569	2056	Chemical	Gene	START_ENTITY|dep|modulator modulator|nmod|function function|nmod|patients patients|acl|treated treated|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Nitric_oxide -- a potential modulator of left ventricular diastolic function in hemodialysis patients treated with erythropoietin -RSB- .
21383158	0	Nitric_oxide	0,12	erythropoietin	84,98	Nitric oxide	erythropoietin	MESH:D009569	13856(Tax:10090)	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|advcl|inducing inducing|dobj|expression expression|nmod|END_ENTITY	Nitric_oxide prevents axonal_degeneration by inducing HIF-1-dependent expression of erythropoietin .
7485461	0	Nitric_oxide	0,12	erythropoietin	28,42	Nitric oxide	erythropoietin	MESH:D009569	24335(Tax:10116)	Chemical	Gene	enhancement|amod|START_ENTITY enhancement|nmod|production production|compound|END_ENTITY	Nitric_oxide enhancement of erythropoietin production in the isolated perfused rat kidney .
8781191	0	Nitric_oxide	0,12	erythropoietin	29,43	Nitric oxide	erythropoietin	MESH:D009569	2056	Chemical	Gene	donors|amod|START_ENTITY suppress|nsubj|donors suppress|dobj|production production|compound|END_ENTITY	Nitric_oxide donors suppress erythropoietin production in vitro .
16049167	0	Nitric_oxide	0,12	extracellular-signal_regulated_kinase	106,143	Nitric oxide	extracellular-signal regulated kinase	MESH:D009569	5594	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|suppression suppression|nmod|phosphorylation phosphorylation|amod|END_ENTITY	Nitric_oxide inhibits endothelin-1-induced cardiomyocyte hypertrophy through cGMP-mediated suppression of extracellular-signal_regulated_kinase phosphorylation .
12477525	0	Nitric_oxide	0,12	gelatinase_A	21,33	Nitric oxide	gelatinase A	MESH:D009569	81686(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Nitric_oxide induces gelatinase_A -LRB- matrix_metalloproteinase_2 -RRB- during rat embryo implantation .
11245631	0	Nitric_oxide	0,12	granulocyte_macrophage_colony-stimulating_factor	41,89	Nitric oxide	granulocyte macrophage colony-stimulating factor	MESH:D009569	1437	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Nitric_oxide inhibits rhinovirus-induced granulocyte_macrophage_colony-stimulating_factor production in bronchial epithelial cells .
10442575	0	Nitric_oxide	0,12	growth_hormone	61,75	Nitric oxide	growth hormone	MESH:D009569	2688	Chemical	Gene	mediation|amod|START_ENTITY mediation|nmod|effects effects|nmod|END_ENTITY	Nitric_oxide and the mediation of the hemodynamic effects of growth_hormone in humans .
10559669	0	Nitric_oxide	0,12	growth_hormone	24,38	Nitric oxide	growth hormone	MESH:D009569	2688	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|amod|END_ENTITY	Nitric_oxide stimulates growth_hormone secretion in vitro through a calcium - and cyclic_guanosine_monophosphate-independent mechanism .
16388095	0	Nitric_oxide	0,12	growth_hormone	24,38	Nitric oxide	growth hormone	MESH:D009569	2688	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|amod|END_ENTITY	Nitric_oxide stimulates growth_hormone secretion from human fetal pituitaries and cultured pituitary_adenomas .
8981915	0	Nitric_oxide	0,12	growth_hormone	105,119	Nitric oxide	growth hormone	MESH:D009569	2688	Chemical	Gene	mediate|nsubj|START_ENTITY mediate|nmod|patients patients|nmod|deficiency deficiency|compound|END_ENTITY	Nitric_oxide may mediate the hemodynamic effects of recombinant growth_hormone in patients with acquired growth_hormone deficiency .
8981915	0	Nitric_oxide	0,12	growth_hormone	64,78	Nitric oxide	growth hormone	MESH:D009569	2688	Chemical	Gene	mediate|nsubj|START_ENTITY mediate|dobj|effects effects|nmod|END_ENTITY	Nitric_oxide may mediate the hemodynamic effects of recombinant growth_hormone in patients with acquired growth_hormone deficiency .
12372604	0	Nitric_oxide	0,12	haptoglobin	47,58	Nitric oxide	haptoglobin	MESH:D009569	15439(Tax:10090)	Chemical	Gene	synthesis|compound|START_ENTITY involved|nsubjpass|synthesis involved|nmod|expression expression|compound|END_ENTITY	Nitric_oxide synthesis is involved in arterial haptoglobin expression after sustained flow changes .
10231435	0	Nitric_oxide	0,12	heme_oxygenase-1	21,37	Nitric oxide	heme oxygenase-1	MESH:D009569	15368(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Nitric_oxide induces heme_oxygenase-1 gene expression in mesangial cells .
10872747	0	Nitric_oxide	0,12	heme_oxygenase-1	21,37	Nitric oxide	heme oxygenase-1	MESH:D009569	3162	Chemical	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Nitric_oxide induces heme_oxygenase-1 via mitogen-activated protein kinases ERK and p38 .
12676888	0	Nitric_oxide	0,12	heme_oxygenase-1	87,103	Nitric oxide	heme oxygenase-1	MESH:D009569	24451(Tax:10116)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|dep|induction induction|nmod|END_ENTITY	Nitric_oxide inhibitor N_omega _ - nitro-l-arginine_methyl_ester potentiates induction of heme_oxygenase-1 in kidney_ischemia / reperfusion model : a novel mechanism for regulation of the oxygenase .
12706494	0	Nitric_oxide	0,12	heme_oxygenase-1	66,82	Nitric oxide	heme oxygenase-1	MESH:D009569	15368(Tax:10090)	Chemical	Gene	priming|amod|START_ENTITY protects|nsubj|priming protects|dobj|apoptosis apoptosis|nmod|induction induction|amod|END_ENTITY	Nitric_oxide priming protects nitric_oxide-mediated apoptosis via heme_oxygenase-1 induction .
17290487	0	Nitric_oxide	1,13	heme_oxygenase-1	14,30	Nitric oxide	heme oxygenase-1	MESH:D009569	24451(Tax:10116)	Chemical	Gene	START_ENTITY|dep|mediates mediates|amod|END_ENTITY	-LSB- Nitric_oxide / heme_oxygenase-1 mediates the antioxidant effect of ACEI in rat aortic rings -RSB- .
17408602	0	Nitric_oxide	0,12	heme_oxygenase-1	24,40	Nitric oxide	heme oxygenase-1	MESH:D009569	24451(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|transcription transcription|amod|END_ENTITY	Nitric_oxide stimulates heme_oxygenase-1 gene transcription via the Nrf2/ARE complex to promote vascular smooth muscle cell survival .
19652369	0	Nitric_oxide	0,12	heme_oxygenase-1	57,73	Nitric oxide	heme oxygenase-1	MESH:D009569	3162	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	Nitric_oxide modulates osteoblastic differentiation with heme_oxygenase-1 via the mitogen activated protein kinase and nuclear factor-kappaB pathways in human periodontal ligament cells .
9781726	0	Nitric_oxide	0,12	heme_oxygenase-1	78,94	Nitric oxide	heme oxygenase-1	MESH:D009569	24451(Tax:10116)	Chemical	Gene	inhibition|amod|START_ENTITY affect|nsubj|inhibition affect|dobj|expression expression|amod|END_ENTITY	Nitric_oxide synthase inhibition and the induction of cytochrome_P-450 affect heme_oxygenase-1 messenger RNA expression after partial hepatectomy and acute inflammation in rats .
9927151	0	Nitric_oxide	0,12	heme_oxygenase-1	75,91	Nitric oxide	heme oxygenase-1	MESH:D009569	24451(Tax:10116)	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|dobj|upregulation upregulation|nmod|expression expression|amod|END_ENTITY	Nitric_oxide mediates the lipopolysaccharide dependent upregulation of the heme_oxygenase-1 gene expression in cultured rat Kupffer cells .
20233223	0	Nitric_oxide	0,12	hypoxia_inducible_factor-1alpha	70,101	Nitric oxide	hypoxia inducible factor-1alpha	MESH:D009569	29560(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|xcomp|END_ENTITY	Nitric_oxide , derived from inducible nitric_oxide synthase , decreases hypoxia_inducible_factor-1alpha in macrophages during aspirin-induced mesenteric_inflammation .
10102685	1	Nitric_oxide	124,136	iNOS	206,210	Nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	START_ENTITY|acl|synthesized synthesized|nmod|isoform isoform|nmod|synthase synthase|appos|END_ENTITY	Nitric_oxide -LRB- NO -RRB- , synthesized by the inducible isoform of nitric_oxide synthase -LRB- iNOS -RRB- , has been proposed as a mediator of immune-induced beta-cell destruction in type 1 diabetes .
11396931	0	Nitric_oxide	0,12	iNOS	55,59	Nitric oxide	iNOS	MESH:D009569	24599(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inducible_nitric_oxide_synthase inducible_nitric_oxide_synthase|appos|END_ENTITY	Nitric_oxide from the inducible_nitric_oxide_synthase -LRB- iNOS -RRB- increases the expression of cytochrome_P450_2E1 in iNOS-null hepatocytes in the absence of inflammatory stimuli .
11446856	6	Nitric_oxide	1037,1049	iNOS	1063,1067	Nitric oxide	iNOS	MESH:D009569	4843	Chemical	Gene	START_ENTITY|acl|generated generated|advcl|involved involved|nsubjpass|END_ENTITY	CONCLUSIONS : Nitric_oxide generated by iNOS may be involved in prostate tumorigenesis and further studies with immunohistochemical and molecular biology are needed to determine the exact role of iNOS in the pathogenesis of prostatic_carcinoma .
11827691	0	Nitric_oxide	0,12	iNOS	121,125	Nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	START_ENTITY|advcl|eNOS eNOS|acl|masquerading masquerading|nmod|END_ENTITY	Nitric_oxide as a mediator of delayed pharmacological -LRB- A -LRB- 1 -RRB- receptor triggered -RRB- preconditioning ; is eNOS masquerading as iNOS ?
12381419	0	Nitric_oxide	0,12	iNOS	27,31	Nitric oxide	iNOS	MESH:D009569	24599(Tax:10116)	Chemical	Gene	START_ENTITY|acl|released released|nmod|END_ENTITY	Nitric_oxide released from iNOS in polymorphonuclear leukocytes makes them deformable in an autocrine manner .
15072593	0	Nitric_oxide	0,12	iNOS	26,30	Nitric oxide	iNOS	MESH:D009569	4843	Chemical	Gene	START_ENTITY|acl|generated generated|nmod|END_ENTITY	Nitric_oxide generated by iNOS reduces deformability of Lewis_lung_carcinoma cells .
16517189	0	Nitric_oxide	0,12	iNOS	25,29	Nitric oxide	iNOS	MESH:D009569	4843	Chemical	Gene	START_ENTITY|acl|produced produced|nmod|END_ENTITY	Nitric_oxide produced by iNOS is associated with collagen synthesis in keloid scar formation .
16574649	0	Nitric_oxide	0,12	iNOS	123,127	Nitric oxide	iNOS	MESH:D009569	24599(Tax:10116)	Chemical	Gene	signaling|compound|START_ENTITY modulates|nsubj|signaling modulates|dobj|expression expression|amod|END_ENTITY	Nitric_oxide signaling via nuclearized endothelial nitric-oxide synthase modulates expression of the immediate early genes iNOS and mPGES-1 .
18639532	0	Nitric_oxide	0,12	iNOS	29,33	Nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	START_ENTITY|acl|associated associated|nmod|expression expression|amod|END_ENTITY	Nitric_oxide associated with iNOS expression inhibits acetylcholinesterase activity and induces memory_impairment during acute hypobaric hypoxia .
11360250	0	Nitric_oxide	0,12	inducible_nitric_oxide_synthase	75,106	Nitric oxide	inducible nitric oxide synthase	MESH:D009569	18126(Tax:10090)	Chemical	Gene	myocarditis|amod|START_ENTITY myocarditis|dep|expression expression|nmod|END_ENTITY	Nitric_oxide and Coxsackievirus B3 myocarditis : differential expression of inducible_nitric_oxide_synthase in mouse heart after infection_with_virulent_or_attenuated_virus .
15365250	0	Nitric_oxide	0,12	inducible_nitric_oxide_synthase	24,55	Nitric oxide	inducible nitric oxide synthase	MESH:D009569	24599(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Nitric_oxide suppresses inducible_nitric_oxide_synthase expression by inhibiting post-translational modification of IkappaB .
9821183	0	Nitric_oxide	0,12	inducible_nitric_oxide_synthase	106,137	Nitric oxide	inducible nitric oxide synthase	MESH:D009569	24599(Tax:10116)	Chemical	Gene	overproduced|nsubjpass|START_ENTITY overproduced|nmod|macrophages macrophages|dep|mechanism mechanism|nmod|expression expression|amod|END_ENTITY	Nitric_oxide is overproduced by peritoneal macrophages in rat taurocholate pancreatitis : the mechanism of inducible_nitric_oxide_synthase expression .
10698278	0	Nitric_oxide	0,12	insulin	47,54	Nitric oxide	insulin	MESH:D009569	3630	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|dobj|effects effects|nmod|END_ENTITY	Nitric_oxide mediates the mitogenic effects of insulin and vascular_endothelial_growth_factor but not of leptin in endothelial cells .
10902577	0	Nitric_oxide	0,12	insulin	40,47	Nitric oxide	insulin	MESH:D009569	3630	Chemical	Gene	START_ENTITY|dep|messenger messenger|nmod|END_ENTITY	Nitric_oxide : the `` second messenger '' of insulin .
15573511	0	Nitric_oxide	1,13	insulin	42,49	Nitric oxide	insulin	MESH:D009569	3630	Chemical	Gene	donors|compound|START_ENTITY donors|appos|treatment treatment|nmod|resistance resistance|compound|END_ENTITY	-LSB- Nitric_oxide donors , a new treatment for insulin resistance , metabolic_syndrome and diabetes ? -RSB- .
15766572	0	Nitric_oxide	0,12	insulin	24,31	Nitric oxide	insulin	MESH:D009569	3630	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|compound|END_ENTITY	Nitric_oxide stimulates insulin release in liver cells expressing human insulin .
15766572	0	Nitric_oxide	0,12	insulin	72,79	Nitric oxide	insulin	MESH:D009569	3630	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|cells cells|acl|expressing expressing|dobj|END_ENTITY	Nitric_oxide stimulates insulin release in liver cells expressing human insulin .
17210120	0	Nitric_oxide	0,12	insulin	24,31	Nitric oxide	insulin	MESH:D009569	3630	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|transcription transcription|compound|END_ENTITY	Nitric_oxide stimulates insulin gene transcription in pancreatic beta-cells .
7503739	0	Nitric_oxide	0,12	insulin	48,55	Nitric oxide	insulin	MESH:D009569	3630	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|compound|END_ENTITY	Nitric_oxide -LRB- nitrogen_monoxide , NO -RRB- stimulates insulin secretion by inducing calcium release from mitochondria .
8383325	0	Nitric_oxide	0,12	insulin	53,60	Nitric oxide	insulin	MESH:D009569	3630	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|dobj|inhibition inhibition|nmod|secretion secretion|compound|END_ENTITY	Nitric_oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans .
8751600	0	Nitric_oxide	0,12	insulin	23,30	Nitric oxide	insulin	MESH:D009569	3630	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|secretion secretion|compound|END_ENTITY	Nitric_oxide regulates insulin secretion in the isolated perfused human pancreas via a cholinergic mechanism .
19154729	0	Nitric_oxide	0,12	insulin-degrading_enzyme	22,46	Nitric oxide	insulin-degrading enzyme	MESH:D009569	3416	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Nitric_oxide inhibits insulin-degrading_enzyme activity and function through S-nitrosylation .
10198224	0	Nitric_oxide	0,12	intercellular_adhesion_molecule-1	44,77	Nitric oxide	intercellular adhesion molecule-1	MESH:D009569	3383	Chemical	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|nmod|cells cells|amod|END_ENTITY	Nitric_oxide up-regulates the expression of intercellular_adhesion_molecule-1 on cancer cells .
10583599	0	Nitric_oxide	0,12	interferon-gamma	35,51	Nitric oxide	interferon-gamma	MESH:D009569	3458	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|amod|END_ENTITY	Nitric_oxide selectively decreases interferon-gamma expression by activated human T lymphocytes via a cGMP-independent mechanism .
7514170	0	Nitric_oxide	0,12	interferon-gamma	62,78	Nitric oxide	interferon-gamma	MESH:D009569	3458	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|,3 ,3|dep|activity activity|nmod|phagocytes phagocytes|amod|primed primed|advmod|END_ENTITY	Nitric_oxide inhibits indoleamine_2 ,3 - dioxygenase activity in interferon-gamma primed mononuclear phagocytes .
7523382	0	Nitric_oxide	0,12	interferon-gamma	98,114	Nitric oxide	interferon-gamma	MESH:D009569	25712(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|nmod|macrophages macrophages|acl|treated treated|nmod|END_ENTITY	Nitric_oxide reduces early_growth_response-1 gene expression in rat lung macrophages treated with interferon-gamma and lipopolysaccharide .
8626684	0	Nitric_oxide	0,12	interferon-gamma	66,82	Nitric oxide	interferon-gamma	MESH:D009569	3458	Chemical	Gene	attenuates|amod|START_ENTITY vascular|nsubj|attenuates vascular|nmod|END_ENTITY	Nitric_oxide attenuates vascular smooth muscle cell activation by interferon-gamma .
11519352	0	Nitric_oxide	1,13	interleukin-1	38,51	Nitric oxide	interleukin-1	MESH:D009569	3552	Chemical	Gene	START_ENTITY|nmod|system system|amod|END_ENTITY	-LSB- Nitric_oxide as main effector in the interleukin-1 system in ovulation -RSB- .
12002297	0	Nitric_oxide	0,12	interleukin-10	27,41	Nitric oxide	interleukin-10	MESH:D009569	3586	Chemical	Gene	START_ENTITY|nmod|surgery surgery|amod|END_ENTITY	Nitric_oxide expression by interleukin-10 in the endoscopic and open methods of vein harvesting in coronary artery bypass surgery .
21564091	0	Nitric_oxide	0,12	interleukin-10	121,135	Nitric oxide	interleukin-10	MESH:D009569	25325(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	Nitric_oxide modulates lipopolysaccharide-induced endothelial platelet_endothelial_cell_adhesion_molecule expression via interleukin-10 .
7986156	0	Nitric_oxide	0,12	interleukin-10	46,60	Nitric oxide	interleukin-10	MESH:D009569	16153(Tax:10090)	Chemical	Gene	normalizes|amod|START_ENTITY splenocyte|nsubj|normalizes splenocyte|dobj|synthesis synthesis|amod|END_ENTITY	Nitric_oxide inhibition normalizes splenocyte interleukin-10 synthesis in murine thermal_injury .
17291992	0	Nitric_oxide	0,12	interleukin-12_p40	22,40	Nitric oxide	interleukin-12 p40	MESH:D009569	3593	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Nitric_oxide inhibits interleukin-12_p40 through p38 MAPK-mediated regulation of calmodulin and c-rel .
15297430	0	Nitric_oxide	0,12	interleukin-13	25,39	Nitric oxide	interleukin-13	MESH:D009569	3598	Chemical	Gene	accelerates|nsubj|START_ENTITY accelerates|dobj|regression regression|amod|END_ENTITY	Nitric_oxide accelerates interleukin-13 cytotoxin-mediated regression in head_and_neck_cancer animal model .
7545507	0	Nitric_oxide	0,12	interleukin-1_beta	54,72	Nitric oxide	interleukin-1 beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	plays|nsubj|START_ENTITY plays|dobj|role role|nmod|release release|acl|induced induced|advcl|END_ENTITY	Nitric_oxide plays no role in ACTH release induced by interleukin-1_beta , corticotropin-releasing_hormone , arginine_vasopressin and phorbol_myristate_acetate in rat pituitary cell cultures .
7578850	0	Nitric_oxide	0,12	interleukin-1_beta	58,76	Nitric oxide	interleukin-1 beta	MESH:D009569	3553	Chemical	Gene	production|amod|START_ENTITY involved|nsubjpass|production involved|nmod|effects effects|nmod|END_ENTITY	Nitric_oxide production is not involved in the effects of interleukin-1_beta on cAMP , thyroglobulin and interleukin-6 in TSH-stimulated human thyroid cells .
7957631	0	Nitric_oxide	0,12	interleukin-1_beta	43,61	Nitric oxide	interleukin-1 beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Nitric_oxide mediates the amplification by interleukin-1_beta of neurogenic vasodilatation in the rat skin .
8428219	0	Nitric_oxide	0,12	interleukin-1_beta	40,58	Nitric oxide	interleukin-1 beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Nitric_oxide mediates the inhibition by interleukin-1_beta of pentagastrin-stimulated rat gastric acid secretion .
8982720	0	Nitric_oxide	0,12	interleukin-1_beta	75,93	Nitric oxide	interleukin-1 beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|nmod|outflow outflow|acl|induced induced|nmod|END_ENTITY	Nitric_oxide mediates central activation of sympathetic outflow induced by interleukin-1_beta in rats .
10619820	0	Nitric_oxide	0,12	interleukin-1beta	23,40	Nitric oxide	interleukin-1beta	MESH:D009569	3553	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|synthesis synthesis|amod|END_ENTITY	Nitric_oxide modulates interleukin-1beta and tumor_necrosis_factor-alpha synthesis by alveolar macrophages in pulmonary_tuberculosis .
11264769	0	Nitric_oxide	0,12	interleukin-1beta	23,40	Nitric oxide	interleukin-1beta	MESH:D009569	3553	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|synthesis synthesis|amod|END_ENTITY	Nitric_oxide modulates interleukin-1beta and tumour necrosis factor-alpha synthesis , and disease regression by alveolar macrophages in pulmonary_tuberculosis .
11330732	0	Nitric_oxide	0,12	interleukin-1beta	43,60	Nitric oxide	interleukin-1beta	MESH:D009569	3553	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|dobj|effect effect|nmod|production production|amod|END_ENTITY	Nitric_oxide mediates inhibitory effect of interleukin-1beta on estrogen production in human granulosa-luteal cells .
12761298	0	Nitric_oxide	0,12	interleukin-1beta	121,138	Nitric oxide	interleukin-1beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	induction|amod|START_ENTITY stimulated|nsubj|induction stimulated|nmod|END_ENTITY	Nitric_oxide synthase induction , cGMP elevation , and biopterin synthesis in vascular smooth muscle cells stimulated with interleukin-1beta in hypoxia .
16204770	0	Nitric_oxide	0,12	interleukin-1beta	26,43	Nitric oxide	interleukin-1beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|dobj|response response|amod|END_ENTITY	Nitric_oxide mediates the interleukin-1beta - and nicotine-induced hypothalamic-pituitary-adrenocortical response during social stress .
12557327	0	Nitric_oxide	1,13	interleukin-2	49,62	Nitric oxide	interleukin-2	MESH:D009569	116562(Tax:10116)	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|dobj|effects effects|nmod|END_ENTITY	-LSB- Nitric_oxide mediates the inhibitory effects of interleukin-2 on the isolated ventricular papillary muscle and cultured neonatal rat cardiomyocyte -RSB- OBJECTIVE : To explore the effects and mechanism of interleukin-2 on the isolated rat ventricular papillary muscle and cultured cardiomyocyte .
15248139	0	Nitric_oxide	0,12	interleukin-2	84,97	Nitric oxide	interleukin-2	MESH:D009569	3558	Chemical	Gene	production|amod|START_ENTITY production|acl|receiving receiving|dobj|cycles cycles|nmod|END_ENTITY	Nitric_oxide production in HIV-1_infected patients receiving intermittent cycles of interleukin-2 and antiretrovirals .
9155642	0	Nitric_oxide	0,12	interleukin-4	23,36	Nitric oxide	interleukin-4	MESH:D009569	3565	Chemical	Gene	increased|nsubj|START_ENTITY increased|dobj|expression expression|compound|END_ENTITY	Nitric_oxide increased interleukin-4 expression in T lymphocytes .
20035621	0	Nitric_oxide	0,12	interleukin-6	24,37	Nitric oxide	interleukin-6	MESH:D009569	16193(Tax:10090)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|amod|END_ENTITY	Nitric_oxide stimulates interleukin-6 production in skeletal myotubes .
10505790	0	Nitric_oxide	0,12	interleukin-8	23,36	Nitric oxide	interleukin-8	MESH:D009569	3576	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Nitric_oxide regulates interleukin-8 gene expression in activated endothelium by inhibiting NF-kappaB binding to DNA : effects on endothelial function .
8989833	0	Nitric_oxide	0,12	interleukin-8	27,40	Nitric oxide	interleukin-8	MESH:D009569	3576	Chemical	Gene	START_ENTITY|dobj|regulation regulation|nmod|expression expression|amod|END_ENTITY	Nitric_oxide regulation of interleukin-8 gene expression .
1384465	0	Nitric_oxide	0,12	interleukin_1_beta	49,67	Nitric oxide	interleukin 1 beta	MESH:D009569	3553	Chemical	Gene	induced|nsubj|START_ENTITY induced|nmod|END_ENTITY	Nitric_oxide and cyclic_GMP formation induced by interleukin_1_beta in islets of Langerhans .
9712106	0	Nitric_oxide	0,12	interleukin_1beta	27,44	Nitric oxide	interleukin 1beta	MESH:D009569	3553	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|IL-1beta IL-1beta|amod|END_ENTITY	Nitric_oxide downregulates interleukin_1beta -LRB- IL-1beta -RRB- stimulated IL-6 , IL-8 , and prostaglandin_E2 production by human chondrocytes .
21305324	0	Nitric_oxide	0,12	intestinal_trefoil_factor	60,85	Nitric oxide	intestinal trefoil factor	MESH:D009569	25563(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|stabilization stabilization|nmod|END_ENTITY	Nitric_oxide induces HIF-1a stabilization and expression of intestinal_trefoil_factor in the damaged rat jejunum and modulates ulcer_healing .
7533289	0	Nitric_oxide	0,12	iron-regulatory_protein	26,49	Nitric oxide	iron-regulatory protein	MESH:D009569	22413(Tax:10090)	Chemical	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Nitric_oxide signaling to iron-regulatory_protein : direct control of ferritin mRNA translation and transferrin receptor mRNA stability in transfected fibroblasts .
12459918	0	Nitric_oxide	0,12	iron_regulatory_protein_1	104,129	Nitric oxide	iron regulatory protein 1	MESH:D009569	48	Chemical	Gene	promote|nsubj|START_ENTITY promote|dobj|disruption disruption|nmod|cluster cluster|nmod|END_ENTITY	Nitric_oxide and peroxynitrite promote complete disruption of the -LSB- 4Fe-4S -RSB- cluster of recombinant human iron_regulatory_protein_1 .
19088434	0	Nitric_oxide	0,12	lipoprotein_lipase	32,50	Nitric oxide	lipoprotein lipase	MESH:D009569	24539(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	Nitric_oxide and the release of lipoprotein_lipase from white_adipose_tissue .
7622526	0	Nitric_oxide	0,12	macrophage-colony_stimulating_factor	22,58	Nitric oxide	macrophage-colony stimulating factor	MESH:D009569	1435	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|transcription transcription|amod|END_ENTITY	Nitric_oxide inhibits macrophage-colony_stimulating_factor gene transcription in vascular endothelial cells .
12707024	0	Nitric_oxide	0,12	maspin	27,33	Nitric oxide	maspin	MESH:D009569	5268	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Nitric_oxide regulation of maspin expression in normal mammary epithelial and breast_cancer cells .
11574667	0	Nitric_oxide	0,12	matrix_metalloproteinase-1	23,49	Nitric oxide	matrix metalloproteinase-1	MESH:D009569	4312	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|production production|amod|END_ENTITY	Nitric_oxide increases matrix_metalloproteinase-1 production in human uterine cervical fibroblast cells .
12954809	0	Nitric_oxide	0,12	matrix_metalloproteinase-9	55,81	Nitric oxide	matrix metalloproteinase-9	MESH:D009569	81687(Tax:10116)	Chemical	Gene	increase|nsubj|START_ENTITY increase|dobj|expression expression|nmod|muscle muscle|amod|END_ENTITY	Nitric_oxide and cyclic_GMP increase the expression of matrix_metalloproteinase-9 in vascular smooth muscle .
17942699	0	Nitric_oxide	0,12	matrix_metalloproteinase-9	23,49	Nitric oxide	matrix metalloproteinase-9	MESH:D009569	17395(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	Nitric_oxide regulates matrix_metalloproteinase-9 activity by guanylyl-cyclase-dependent and - independent pathways .
21660948	0	Nitric_oxide	0,12	matrix_metalloproteinase-9	100,126	Nitric oxide	matrix metalloproteinase-9	MESH:D009569	81687(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY enhances|nsubj|production enhances|dobj|migration migration|nmod|nitration nitration|nmod|END_ENTITY	Nitric_oxide production by endothelin-1 enhances astrocytic migration via the tyrosine nitration of matrix_metalloproteinase-9 .
23456480	0	Nitric_oxide	0,12	matrix_metalloproteinase-9	24,50	Nitric oxide	matrix metalloproteinase-9	MESH:D009569	4318	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|production production|amod|END_ENTITY	Nitric_oxide attenuates matrix_metalloproteinase-9 production by endothelial cells independent of cGMP - or NFkB-mediated mechanisms .
12477525	0	Nitric_oxide	0,12	matrix_metalloproteinase_2	35,61	Nitric oxide	matrix metalloproteinase 2	MESH:D009569	81686(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dep|END_ENTITY	Nitric_oxide induces gelatinase_A -LRB- matrix_metalloproteinase_2 -RRB- during rat embryo implantation .
15647267	0	Nitric_oxide	0,12	methylmalonyl-CoA_mutase	32,56	Nitric oxide	methylmalonyl-CoA mutase	MESH:D009569	4594	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Nitric_oxide inhibits mammalian methylmalonyl-CoA_mutase .
14659452	0	Nitric_oxide	0,12	monoamine_oxidase	36,53	Nitric oxide	monoamine oxidase	MESH:D009569	29253(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	Nitric_oxide inhibits mitochondrial monoamine_oxidase activity and decreases outer mitochondria membrane fluidity .
7758169	0	Nitric_oxide	0,12	monocyte_chemoattractant_protein_1	41,75	Nitric oxide	monocyte chemoattractant protein 1	MESH:D009569	6347	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	Nitric_oxide modulates the expression of monocyte_chemoattractant_protein_1 in cultured human endothelial cells .
9264504	0	Nitric_oxide	0,12	monocyte_chemotactic_protein-1	23,53	Nitric oxide	monocyte chemotactic protein-1	MESH:D009569	100009130(Tax:9986)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	Nitric_oxide regulates monocyte_chemotactic_protein-1 .
16847357	0	Nitric_oxide	0,12	mucin	68,73	Nitric oxide	mucin	MESH:D009569	65202(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY contributes|nsubj|activity contributes|xcomp|END_ENTITY	Nitric_oxide synthase activity in rat gastric mucosa contributes to mucin synthesis elicited by calcitonin_gene-related_peptide .
9121782	0	Nitric_oxide	0,12	mucin	22,27	Nitric oxide	mucin	MESH:D009569	65202(Tax:10116)	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|dobj|secretion secretion|compound|END_ENTITY	Nitric_oxide mediates mucin secretion in endotoxin-induced otitis media with effusion .
10036989	0	Nitric_oxide	104,116	nNOS	95,99	Nitric oxide	nNOS	MESH:D009569	18125(Tax:10090)	Chemical	Gene	gene|dep|START_ENTITY gene|dep|END_ENTITY	Circadian locomotor analysis of male mice lacking the gene for neuronal nitric_oxide synthase -LRB- nNOS - / - -RRB- Nitric_oxide -LRB- NO -RRB- is an endogenous gas that functions as a neurotransmitter .
11571247	0	Nitric_oxide	0,12	nNOS	23,27	Nitric oxide	nNOS	MESH:D009569	100009243(Tax:9986)	Chemical	Gene	transfer|compound|START_ENTITY transfer|compound|END_ENTITY	Nitric_oxide synthase -LRB- nNOS -RRB- gene transfer modifies venous bypass graft remodeling : effects on vascular smooth_muscle_cell differentiation and superoxide production .
15614448	0	Nitric_oxide	0,12	nNOS	26,30	Nitric oxide	nNOS	MESH:D009569	24598(Tax:10116)	Chemical	Gene	START_ENTITY|acl|generated generated|nmod|END_ENTITY	Nitric_oxide generated by nNOS in the macula densa regulates the afferent arteriolar diameter in rat kidney .
19252090	0	Nitric_oxide	0,12	natriuretic_peptide_receptor_C	42,72	Nitric oxide	natriuretic peptide receptor C	MESH:D009569	25339(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|nmod|END_ENTITY	Nitric_oxide attenuates the expression of natriuretic_peptide_receptor_C and associated adenylyl cyclase signaling in aortic vascular smooth muscle cells : role of MAPK .
8798403	0	Nitric_oxide	0,12	neurogranin	39,50	Nitric oxide	neurogranin	MESH:D009569	64356(Tax:10116)	Chemical	Gene	modification|amod|START_ENTITY modification|nmod|END_ENTITY	Nitric_oxide modification of rat brain neurogranin affects its phosphorylation by protein_kinase_C and affinity for calmodulin .
10775125	0	Nitric_oxide	0,12	neuronal_NOS	26,38	Nitric oxide	neuronal NOS	MESH:D009569	24598(Tax:10116)	Chemical	Gene	START_ENTITY|acl|produced produced|nmod|END_ENTITY	Nitric_oxide produced via neuronal_NOS may impair vasodilatation in septic rat skeletal muscle .
10462479	0	Nitric_oxide	0,12	ornithine_decarboxylase	22,45	Nitric oxide	ornithine decarboxylase	MESH:D009569	4953	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Nitric_oxide inhibits ornithine_decarboxylase by S-nitrosylation .
11461922	0	Nitric_oxide	0,12	ornithine_decarboxylase	22,45	Nitric oxide	ornithine decarboxylase	MESH:D009569	4953	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Nitric_oxide inhibits ornithine_decarboxylase via S-nitrosylation of cysteine 360 in the active site of the enzyme .
10664504	0	Nitric_oxide	0,12	p21	22,25	Nitric oxide	p21	MESH:D009569	24525(Tax:10116)	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|dobj|degradation degradation|amod|END_ENTITY	Nitric_oxide prevents p21 degradation with the ubiquitin-proteasome pathway in vascular smooth muscle cells .
10753954	0	Nitric_oxide	0,12	p21	23,26	Nitric oxide	p21	MESH:D009569	1026	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Nitric_oxide increases p21 -LRB- Waf1/Cip1 -RRB- expression by a cGMP-dependent pathway that includes activation of extracellular_signal-regulated_kinase and p70 -LRB- S6k -RRB- .
11585574	0	Nitric_oxide	0,12	p21	96,99	Nitric oxide	p21	MESH:D009569	12575(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|mechanism mechanism|acl|involving involving|xcomp|END_ENTITY	Nitric_oxide inhibits the proliferation of murine microglial MG5 cells by a mechanism involving p21 but independent of p53 and cyclic_guanosine_monophosphate .
16914115	0	Nitric_oxide	0,12	p21Ras	88,94	Nitric oxide	p21Ras	MESH:D009569	3265	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|translocation translocation|dep|association association|nmod|pathway pathway|amod|END_ENTITY	Nitric_oxide induces thioredoxin-1 nuclear translocation : possible association with the p21Ras survival pathway .
12941159	0	Nitric_oxide	0,12	p21ras	23,29	Nitric oxide	p21ras	MESH:D009569	3265	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Nitric_oxide activates p21ras and leads to the inhibition of endothelial NO_synthase by protein nitration .
9576960	0	Nitric_oxide	0,12	p21ras	74,80	Nitric oxide	p21ras	MESH:D009569	15461(Tax:10090)	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|nmod|END_ENTITY	Nitric_oxide mediates N-methyl-D-aspartate receptor-induced activation of p21ras .
10021319	0	Nitric_oxide	0,12	p38	60,63	Nitric oxide	p38	MESH:D009569	81649(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Nitric_oxide stimulates the stress-activated protein kinase p38 in rat renal mesangial cells .
10919842	0	Nitric_oxide	0,12	p38	63,66	Nitric oxide	p38	MESH:D009569	1432	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activation activation|nmod|MAPK MAPK|amod|END_ENTITY	Nitric_oxide modulates mechanical strain-induced activation of p38 MAPK in mesangial cells .
15178710	0	Nitric_oxide	0,12	p38	85,88	Nitric oxide	p38	MESH:D009569	1432	Chemical	Gene	post-transcriptionally|amod|START_ENTITY up-regulates|nsubj|post-transcriptionally up-regulates|nmod|activation activation|amod|END_ENTITY	Nitric_oxide post-transcriptionally up-regulates LPS-induced IL-8 expression through p38 MAPK activation .
16778361	0	Nitric_oxide	0,12	p38	129,132	Nitric oxide	p38	MESH:D009569	26416(Tax:10090)	Chemical	Gene	START_ENTITY|parataxis|protects protects|advcl|inhibiting inhibiting|dobj|activation activation|nmod|kinase kinase|amod|END_ENTITY	Nitric_oxide / cGMP signaling pathway protects RAW264 cells against nitric_oxide-induced apoptosis by inhibiting the activation of p38 mitogen-activated protein kinase .
17197391	0	Nitric_oxide	0,12	p38	86,89	Nitric oxide	p38	MESH:D009569	1432	Chemical	Gene	activation|amod|START_ENTITY gamma|nsubj|activation gamma|nmod|MAPK MAPK|amod|END_ENTITY	Nitric_oxide activation of peroxisome proliferator-activated receptor gamma through a p38 MAPK signaling pathway .
18324518	0	Nitric_oxide	0,12	p38	26,29	Nitric oxide	p38	MESH:D009569	1432	Chemical	Gene	activated|nsubj|START_ENTITY activated|nmod|apoptosis apoptosis|amod|END_ENTITY	Nitric_oxide activated by p38 and NF-kappaB facilitates apoptosis and cell cycle arrest under oxidative stress in evodiamine-treated human melanoma A375-S2 cells .
19258725	0	Nitric_oxide	0,12	p38	38,41	Nitric oxide	p38	MESH:D009569	1432	Chemical	Gene	START_ENTITY|nmod|signal signal|nmod|END_ENTITY	Nitric_oxide as an upstream signal of p38 mediates hypoxia/reoxygenation-induced neuronal_death .
10397271	0	Nitric_oxide	0,12	p53	115,118	Nitric oxide	p53	MESH:D009569	7157	Chemical	Gene	initiator|nsubj|START_ENTITY initiator|nmod|signal signal|acl|transduction transduction|nmod|hyperthermia hyperthermia|nmod|cells cells|compound|END_ENTITY	Nitric_oxide is an initiator of intercellular signal transduction for stress response after hyperthermia in mutant p53 cells of human glioblastoma .
10631110	0	Nitric_oxide	0,12	p53	60,63	Nitric oxide	p53	MESH:D009569	7157	Chemical	Gene	nitrates|amod|START_ENTITY tyrosine|nsubj|nitrates tyrosine|dobj|residues residues|nmod|protein protein|compound|END_ENTITY	Nitric_oxide nitrates tyrosine residues of tumor-suppressor p53 protein in MCF-7 cells .
11237724	0	Nitric_oxide	0,12	p53	77,80	Nitric oxide	p53	MESH:D009569	7157	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|advcl|impairing impairing|dobj|function function|compound|END_ENTITY	Nitric_oxide prevents gamma-radiation-induced cell cycle arrest by impairing p53 function in MCF-7 cells .
11257724	0	Nitric_oxide	0,12	p53	81,84	Nitric oxide	p53	MESH:D009569	7157	Chemical	Gene	synthase|nsubj|START_ENTITY synthase|nmod|END_ENTITY	Nitric_oxide synthase type 1 expression in human lung_cancer and its relation to p53 .
11585574	0	Nitric_oxide	0,12	p53	119,122	Nitric oxide	p53	MESH:D009569	22060(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|mechanism mechanism|acl|involving involving|nmod|END_ENTITY	Nitric_oxide inhibits the proliferation of murine microglial MG5 cells by a mechanism involving p21 but independent of p53 and cyclic_guanosine_monophosphate .
11902831	0	Nitric_oxide	0,12	p53	108,111	Nitric oxide	p53	MESH:D009569	22060(Tax:10090)	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|inhibition inhibition|nmod|upregulation upregulation|compound|END_ENTITY	Nitric_oxide protects thymocytes from gamma-irradiation-induced apoptosis in correlation with inhibition of p53 upregulation and mitochondrial_damage .
11947902	0	Nitric_oxide	0,12	p53	43,46	Nitric oxide	p53	MESH:D009569	7157	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|dobj|accumulation accumulation|compound|END_ENTITY	Nitric_oxide prevents oxidised LDL-induced p53 accumulation , cytochrome_c translocation , and apoptosis in macrophages via guanylate cyclase stimulation .
12719724	0	Nitric_oxide	0,12	p53	22,25	Nitric oxide	p53	MESH:D009569	7157	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|retention retention|nummod|END_ENTITY	Nitric_oxide promotes p53 nuclear retention and sensitizes neuroblastoma cells to apoptosis by ionizing radiation .
12771937	0	Nitric_oxide	0,12	p53	40,43	Nitric oxide	p53	MESH:D009569	22060(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Nitric_oxide induces phosphorylation of p53 and impairs nuclear export .
12927814	0	Nitric_oxide	0,12	p53	56,59	Nitric oxide	p53	MESH:D009569	7157	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|dobj|phosphorylation phosphorylation|nmod|protein protein|compound|END_ENTITY	Nitric_oxide prevents UV-induced phosphorylation of the p53 tumor-suppressor protein at serine 46 : a possible role in inhibition of apoptosis .
15520210	0	Nitric_oxide	0,12	p53	116,119	Nitric oxide	p53	MESH:D009569	7157	Chemical	Gene	radiation|amod|START_ENTITY promote|nsubj|radiation promote|advcl|activating activating|dobj|END_ENTITY	Nitric_oxide and ionizing radiation synergistically promote apoptosis and growth inhibition of cancer by activating p53 .
15979383	0	Nitric_oxide	0,12	p53	71,74	Nitric oxide	p53	MESH:D009569	7157	Chemical	Gene	induces|nsubj|START_ENTITY induces|ccomp|apoptosis apoptosis|nmod|accumulation accumulation|compound|END_ENTITY	Nitric_oxide induces oral_squamous_cell_carcinoma cells apoptosis with p53 accumulation .
17875988	0	Nitric_oxide	0,12	p53	82,85	Nitric oxide	p53	MESH:D009569	22060(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|CD25 CD25|acl|+ +|nmod|cells cells|nmod|END_ENTITY	Nitric_oxide induces CD4 + CD25 + Foxp3 regulatory T cells from CD4 + CD25 T cells via p53 , IL-2 , and OX40 .
7554056	0	Nitric_oxide	0,12	p53	64,67	Nitric oxide	p53	MESH:D009569	7157	Chemical	Gene	START_ENTITY|dep|mutagenicity mutagenicity|nmod|suppressor suppressor|compound|END_ENTITY	Nitric_oxide and ethylnitrosourea : relative mutagenicity in the p53 tumor suppressor and hypoxanthine-phosphoribosyltransferase genes .
9269997	0	Nitric_oxide	0,12	p53	78,81	Nitric oxide	p53	MESH:D009569	7157	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|modifications modifications|nmod|protein protein|compound|END_ENTITY	Nitric_oxide induces conformational and functional modifications of wild-type p53 tumor suppressor protein .
16299053	0	Nitric_oxide	0,12	phosphodiesterase_4B	21,41	Nitric oxide	phosphodiesterase 4B	MESH:D009569	24626(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Nitric_oxide induces phosphodiesterase_4B expression in rat pulmonary artery smooth muscle cells .
9280295	0	Nitric_oxide	0,12	phospholipase_D	47,62	Nitric oxide	phospholipase D	MESH:D009569	2822	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Nitric_oxide inhibits enterocyte mitochondrial phospholipase_D .
21564091	0	Nitric_oxide	0,12	platelet_endothelial_cell_adhesion_molecule	62,105	Nitric oxide	platelet endothelial cell adhesion molecule	MESH:D009569	29583(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|compound|END_ENTITY	Nitric_oxide modulates lipopolysaccharide-induced endothelial platelet_endothelial_cell_adhesion_molecule expression via interleukin-10 .
15936714	0	Nitric_oxide	0,12	prion_protein	21,34	Nitric oxide	prion protein	MESH:D009569	5621	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Nitric_oxide induces prion_protein via MEK and p38 MAPK signaling .
12810546	0	Nitric_oxide	0,12	prolactin	22,31	Nitric oxide	prolactin	MESH:D009569	5617	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|compound|END_ENTITY	Nitric_oxide inhibits prolactin secretion in pituitary cells downstream of voltage-gated calcium influx .
16167338	0	Nitric_oxide	0,12	prolidase	23,32	Nitric oxide	prolidase	MESH:D009569	5184	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	Nitric_oxide regulates prolidase activity by serine/threonine phosphorylation .
10446212	0	Nitric_oxide	0,12	proline-rich_tyrosine_kinase_2	97,127	Nitric oxide	proline-rich tyrosine kinase 2	MESH:D009569	50646(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Nitric_oxide inhibits angiotensin_II-induced activation of the calcium-sensitive tyrosine kinase proline-rich_tyrosine_kinase_2 without affecting epidermal_growth_factor_receptor transactivation .
11839754	0	Nitric_oxide	0,12	protein_kinase_Cepsilon	39,62	Nitric oxide	protein kinase Cepsilon	MESH:D009569	100009103(Tax:9986)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|nitration nitration|nmod|END_ENTITY	Nitric_oxide -LRB- NO -RRB- induces nitration of protein_kinase_Cepsilon -LRB- PKCepsilon -RRB- , facilitating PKCepsilon translocation via enhanced PKCepsilon - RACK2 interactions : a novel mechanism of no-triggered activation of PKCepsilon .
14525937	0	Nitric_oxide	0,12	proteinase	37,47	Nitric oxide	proteinase	MESH:D009569	100616101	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Nitric_oxide inhibits the adenovirus proteinase in vitro and viral infectivity in vivo .
11941405	0	Nitric_oxide	0,12	proto-oncogene_c-fos	40,60	Nitric oxide	proto-oncogene c-fos	MESH:D009569	314322(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Nitric_oxide inhibits the expression of proto-oncogene_c-fos induced by angiotensin_II and endothelin-1 in cardiomyocytes .
8619788	0	Nitric_oxide	0,12	rap1b	47,52	Nitric oxide	rap1b	MESH:D009569	5908	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Nitric_oxide stimulates the phosphorylation of rap1b in human platelets and acts synergistically with iloprost .
14563699	0	Nitric_oxide	0,12	receptor_activator_of_nuclear_factor-kappaB_ligand	23,73	Nitric oxide	receptor activator of nuclear factor-kappaB ligand	MESH:D009569	21943(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Nitric_oxide regulates receptor_activator_of_nuclear_factor-kappaB_ligand and osteoprotegerin expression in bone marrow stromal cells .
11557622	0	Nitric_oxide	0,12	renin	55,60	Nitric oxide	renin	MESH:D009569	24715(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|stimulation stimulation|nmod|secretion secretion|compound|END_ENTITY	Nitric_oxide synthase and cGMP-mediated stimulation of renin secretion .
11702851	0	Nitric_oxide	0,12	renin	116,121	Nitric oxide	renin	MESH:D009569	24715(Tax:10116)	Chemical	Gene	levels|amod|START_ENTITY correlate|nsubj|levels correlate|nmod|expression expression|nmod|receptors receptors|appos|END_ENTITY	Nitric_oxide synthase mRNA levels correlate with gene expression of angiotensin_II type-1 but not type-2 receptors , renin or angiotensin converting enzyme in selected brain areas .
8594876	0	Nitric_oxide	0,12	renin	80,85	Nitric oxide	renin	MESH:D009569	24715(Tax:10116)	Chemical	Gene	involved|nsubjpass|START_ENTITY involved|nmod|control control|nmod|system system|compound|END_ENTITY	Nitric_oxide and prostaglandins are involved in the macula densa control of the renin system .
22914857	0	Nitric_oxide	0,12	soluble_guanylate_cyclase	49,74	Nitric oxide	soluble guanylate cyclase	MESH:D009569	25206(Tax:10116)	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Nitric_oxide - and heme-independent activation of soluble_guanylate_cyclase attenuates peroxynitrite-induced endothelial_dysfunction in rat aorta .
9259594	0	Nitric_oxide	0,12	soluble_guanylate_cyclase	51,76	Nitric oxide	soluble guanylate cyclase	MESH:D009569	25206(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|stability stability|nmod|mRNAs mRNAs|acl|encoding encoding|dobj|subunits subunits|amod|END_ENTITY	Nitric_oxide decreases stability of mRNAs encoding soluble_guanylate_cyclase subunits in rat pulmonary artery smooth muscle cells .
12145809	0	Nitric_oxide	0,12	somatostatin	38,50	Nitric oxide	somatostatin	MESH:D009569	100353697(Tax:9986)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|release release|nmod|END_ENTITY	Nitric_oxide regulates the release of somatostatin from cultured gastric rabbit primary D-cells .
8906868	0	Nitric_oxide	0,12	stress-activated_protein_kinases	24,56	Nitric oxide	stress-activated protein kinases	MESH:D009569	50658(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Nitric_oxide stimulates stress-activated_protein_kinases in glomerular endothelial and mesangial cells .
11275297	0	Nitric_oxide	0,12	substance_P	58,69	Nitric oxide	substance P	MESH:D009569	21333(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|effect effect|nmod|END_ENTITY	Nitric_oxide involvement in the anxiogenic-like effect of substance_P .
8951939	0	Nitric_oxide	0,12	substance_P	94,105	Nitric oxide	substance P	MESH:D009569	21333(Tax:10090)	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|dobj|effects effects|nmod|N-terminus N-terminus|nmod|END_ENTITY	Nitric_oxide mediates long-term hyperalgesic and antinociceptive effects of the N-terminus of substance_P in the formalin assay in mice .
15208261	0	Nitric_oxide	0,12	surfactant_protein-B	39,59	Nitric oxide	surfactant protein-B	MESH:D009569	20388(Tax:10090)	Chemical	Gene	down-regulates|amod|START_ENTITY END_ENTITY|nsubj|down-regulates	Nitric_oxide synthase-2 down-regulates surfactant_protein-B expression and enhances endotoxin-induced lung_injury in mice .
9671381	0	Nitric_oxide	0,12	surfactant_protein_A	23,43	Nitric oxide	surfactant protein A	MESH:D009569	653509	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|compound|END_ENTITY	Nitric_oxide decreases surfactant_protein_A gene expression in H441 cells .
12896877	0	Nitric_oxide	0,12	surfactant_protein_B	22,42	Nitric oxide	surfactant protein B	MESH:D009569	20388(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Nitric_oxide inhibits surfactant_protein_B gene expression in lung epithelial cells .
9877228	0	Nitric_oxide	0,12	thyroid_peroxidase	22,40	Nitric oxide	thyroid peroxidase	MESH:D009569	7173	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|amod|END_ENTITY	Nitric_oxide enhances thyroid_peroxidase activity in primary human thyrocytes .
17339540	0	Nitric_oxide	0,12	tissue_plasminogen_activator	23,51	Nitric oxide	tissue plasminogen activator	MESH:D009569	100128998	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|release release|compound|END_ENTITY	Nitric_oxide modulates tissue_plasminogen_activator release in normotensive subjects and hypertensive patients .
9075810	0	Nitric_oxide	0,12	transforming_growth_factor-beta	27,58	Nitric oxide	transforming growth factor-beta	MESH:D009569	7040	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|synthesis synthesis|compound|END_ENTITY	Nitric_oxide inhibition of transforming_growth_factor-beta and collagen synthesis in mesangial cells .
9038216	0	Nitric_oxide	0,12	tumor_necrosis_factor	23,44	Nitric oxide	tumor necrosis factor	MESH:D009569	7124	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|production production|compound|END_ENTITY	Nitric_oxide increases tumor_necrosis_factor production in differentiated U937 cells by decreasing cyclic_AMP .
10982547	0	Nitric_oxide	0,12	tumor_necrosis_factor-alpha	22,49	Nitric oxide	tumor necrosis factor-alpha	MESH:D009569	7124	Chemical	Gene	provokes|nsubj|START_ENTITY provokes|dobj|expression expression|amod|END_ENTITY	Nitric_oxide provokes tumor_necrosis_factor-alpha expression in adult feline myocardium through a cGMP-dependent pathway .
11118442	0	Nitric_oxide	0,12	tumor_necrosis_factor-alpha	121,148	Nitric oxide	tumor necrosis factor-alpha	MESH:D009569	7124	Chemical	Gene	activation|amod|START_ENTITY Role|dep|activation Role|nmod|sensitization sensitization|nmod|cells cells|nmod|END_ENTITY	Nitric_oxide disrupts H2O2-dependent activation of nuclear factor kappa B. Role in sensitization of human tumor cells to tumor_necrosis_factor-alpha - induced cytotoxicity .
11474215	0	Nitric_oxide	0,12	tumor_necrosis_factor-alpha	47,74	Nitric oxide	tumor necrosis factor-alpha	MESH:D009569	24835(Tax:10116)	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|dobj|effect effect|nmod|END_ENTITY	Nitric_oxide mediates the inhibitory effect of tumor_necrosis_factor-alpha on prolactin release .
9369379	0	Nitric_oxide	0,12	tumor_necrosis_factor-alpha	80,107	Nitric oxide	tumor necrosis factor-alpha	MESH:D009569	7124	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|dobj|regulation regulation|nmod|activity activity|acl|induced induced|nmod|END_ENTITY	Nitric_oxide mediates down regulation of lipoprotein lipase activity induced by tumor_necrosis_factor-alpha in brown adipocytes .
10777484	0	Nitric_oxide	0,12	tumor_necrosis_factor_alpha	26,53	Nitric oxide	tumor necrosis factor alpha	MESH:D009569	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Nitric_oxide inhibits the tumor_necrosis_factor_alpha - regulated endocytosis of human dendritic cells in a cyclic_GMP-dependent way .
9628395	0	Nitric_oxide	0,12	tumour_necrosis_factor	27,49	Nitric oxide	tumour necrosis factor	MESH:D009569	21926(Tax:10090)	Chemical	Gene	downregulates|amod|START_ENTITY END_ENTITY|nsubj|downregulates	Nitric_oxide downregulates tumour_necrosis_factor in mRNA in RAW 264.7 cells .
8799163	0	Nitric_oxide	0,12	vascular_cell_adhesion_molecule_1	23,56	Nitric oxide	vascular cell adhesion molecule 1	MESH:D009569	7412	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Nitric_oxide regulates vascular_cell_adhesion_molecule_1 gene expression and redox-sensitive transcriptional events in human vascular endothelial cells .
10544183	0	Nitric_oxide	0,12	vascular_endothelial_growth_factor	44,78	Nitric oxide	vascular endothelial growth factor	MESH:D009569	22339(Tax:10090)	Chemical	Gene	triggers|nsubj|START_ENTITY triggers|dobj|induction induction|nmod|expression expression|compound|END_ENTITY	Nitric_oxide triggers enhanced induction of vascular_endothelial_growth_factor expression in cultured keratinocytes -LRB- HaCaT -RRB- and during cutaneous wound repair .
10712388	0	Nitric_oxide	0,12	vascular_endothelial_growth_factor	38,72	Nitric oxide	vascular endothelial growth factor	MESH:D009569	83785(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|synthesis synthesis|nmod|cells cells|amod|END_ENTITY	Nitric_oxide induces the synthesis of vascular_endothelial_growth_factor by rat vascular smooth muscle cells .
12595343	0	Nitric_oxide	0,12	vascular_endothelial_growth_factor	56,90	Nitric oxide	vascular endothelial growth factor	MESH:D009569	83785(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|angiogenesis angiogenesis|nmod|synthesis synthesis|nmod|END_ENTITY	Nitric_oxide enhances angiogenesis via the synthesis of vascular_endothelial_growth_factor and cGMP after stroke in the rat .
12631117	0	Nitric_oxide	0,12	vascular_endothelial_growth_factor	23,57	Nitric oxide	vascular endothelial growth factor	MESH:D009569	83785(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Nitric_oxide modulates vascular_endothelial_growth_factor and receptors in chronic cyclosporine nephrotoxicity .
16779917	0	Nitric_oxide	0,12	vascular_endothelial_growth_factor	24,58	Nitric oxide	vascular endothelial growth factor	MESH:D009569	7422	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|compound|END_ENTITY	Nitric_oxide stimulates vascular_endothelial_growth_factor production in cardiomyocytes involved in angiogenesis .
18331270	0	Nitric_oxide	0,12	vascular_endothelial_growth_factor	32,66	Nitric oxide	vascular endothelial growth factor	MESH:D009569	7422	Chemical	Gene	synthesis|compound|START_ENTITY leads|nsubj|synthesis leads|nmod|synthesis synthesis|compound|END_ENTITY	Nitric_oxide synthesis leads to vascular_endothelial_growth_factor synthesis via the NO/cyclic _ guanosine_3 ' ,5 ' - monophosphate -LRB- cGMP -RRB- pathway in human corpus cavernosal smooth muscle cells .
18391852	0	Nitric_oxide	0,12	vascular_endothelial_growth_factor	41,75	Nitric oxide	vascular endothelial growth factor	MESH:D009569	7422	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|secretion secretion|nmod|END_ENTITY	Nitric_oxide suppresses the secretion of vascular_endothelial_growth_factor and hepatocyte_growth_factor from human mesenchymal stem cells .
21651424	0	Nitric_oxide	0,12	vascular_endothelial_growth_factor	35,69	Nitric oxide	vascular endothelial growth factor	MESH:D009569	7422	Chemical	Gene	events|amod|START_ENTITY events|nmod|END_ENTITY	Nitric_oxide and adverse events of vascular_endothelial_growth_factor inhibitors .
23649256	0	Nitric_oxide	0,12	vascular_endothelial_growth_factor	21,55	Nitric oxide	vascular endothelial growth factor	MESH:D009569	83785(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Nitric_oxide induces vascular_endothelial_growth_factor expression in the rat placenta in vivo and in vitro .
24142467	0	Nitric_oxide	0,12	vascular_endothelial_growth_factor	51,85	Nitric oxide	vascular endothelial growth factor	MESH:D009569	7422	Chemical	Gene	donors|amod|START_ENTITY augment|nsubj|donors augment|dobj|END_ENTITY	Nitric_oxide donors augment interleukin-1b-induced vascular_endothelial_growth_factor in airway smooth muscle cells .
9399960	0	Nitric_oxide	0,12	vascular_endothelial_growth_factor	68,102	Nitric oxide	vascular endothelial growth factor	MESH:D009569	7422	Chemical	Gene	production|amod|START_ENTITY contributes|nsubj|production contributes|nmod|properties properties|nmod|END_ENTITY	Nitric_oxide production contributes to the angiogenic properties of vascular_endothelial_growth_factor in human endothelial cells .
26985300	0	Nitriles	44,52	Cathepsin_B	0,11	Nitriles	Cathepsin B	MESH:D009570	1508	Chemical	Gene	Inhibitors|dep|START_ENTITY Inhibitors|compound|END_ENTITY	Cathepsin_B Inhibitors : Combining Dipeptide Nitriles with an Occluding Loop Recognition Element by Click Chemistry .
27075937	0	Nitrite	0,7	catalase	52,60	Nitrite	catalase	CHEBI:16301	847	Chemical	Gene	compounds|compound|START_ENTITY serve|nsubj|compounds serve|nmod|inhibitors inhibitors|compound|END_ENTITY	Nitrite and nitroso compounds can serve as specific catalase inhibitors .
10766781	0	Nitrite	0,7	myeloperoxidase	40,55	Nitrite	myeloperoxidase	CHEBI:16301	4353	Chemical	Gene	START_ENTITY|nmod|substrate substrate|nmod|END_ENTITY	Nitrite as a substrate and inhibitor of myeloperoxidase .
15878909	0	Nitrite	0,7	myeloperoxidase	103,118	Nitrite	myeloperoxidase	CHEBI:16301	4353	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|ccomp|strand strand|nmod|inhibition inhibition|nmod|END_ENTITY	Nitrite enhances neutrophil-induced DNA strand breakage in pulmonary epithelial cells by inhibition of myeloperoxidase .
18632562	0	Nitrite	0,7	myoglobin	30,39	Nitrite	myoglobin	CHEBI:16301	17189(Tax:10090)	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Nitrite reductase activity of myoglobin regulates respiration and cellular viability in myocardial_ischemia-reperfusion injury .
8853356	0	Nitrite	0,7	myoglobin	21,30	Nitrite	myoglobin	CHEBI:16301	59108(Tax:10116)	Chemical	Gene	oxidation|amod|START_ENTITY oxidation|nmod|END_ENTITY	Nitrite oxidation of myoglobin in perfused myocardium : implications for energy coupling in respiration .
18289863	0	Nitro	0,5	carboxypeptidase_A	57,75	Nitro	carboxypeptidase A	CHEBI:29785	1357	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Nitro as a novel zinc-binding group in the inhibition of carboxypeptidase_A .
8674740	0	Nitrocatechol	0,13	catechol-O-methyltransferase	43,71	Nitrocatechol	catechol-O-methyltransferase	MESH:C506350	1312	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Nitrocatechol derivatives as inhibitors of catechol-O-methyltransferase .
11196641	0	Nitrogen	0,8	CO2	77,80	Nitrogen	CO2	MESH:D009584	717	Chemical	Gene	limitation|compound|START_ENTITY limitation|nmod|grassland grassland|nmod|END_ENTITY	Nitrogen limitation of microbial decomposition in a grassland under elevated CO2 .
14717432	0	Nitrogen	0,8	CO2	65,68	Nitrogen	CO2	MESH:D009584	717	Chemical	Gene	use|nsubj|START_ENTITY use|advcl|affected affected|nmod|levels levels|nummod|END_ENTITY	Nitrogen use efficiency by a slow-growing species as affected by CO2 levels , root temperature , N source and availability .
16612381	0	Nitrogen	0,8	CO2	71,74	Nitrogen	CO2	MESH:D009584	717	Chemical	Gene	limitation|compound|START_ENTITY constrains|nsubj|limitation constrains|nmod|END_ENTITY	Nitrogen limitation constrains sustainability of ecosystem response to CO2 .
16634294	0	Nitrogen	0,8	CO2	51,54	Nitrogen	CO2	MESH:D009584	717	Chemical	Gene	cycling|compound|START_ENTITY cycling|nmod|years years|nmod|enrichment enrichment|compound|END_ENTITY	Nitrogen cycling during seven years of atmospheric CO2 enrichment in a scrub oak woodland .
20809407	0	Nitrogen	0,8	CO2	63,66	Nitrogen	CO2	MESH:D009584	717	Chemical	Gene	deposition|compound|START_ENTITY limits|nsubj|deposition limits|nmod|differentially differentially|compound|END_ENTITY	Nitrogen deposition limits photosynthetic response to elevated CO2 differentially in a dioecious species .
24610855	0	Nitrogen	0,8	CO2	117,120	Nitrogen	CO2	MESH:D009584	717	Chemical	Gene	fertilization|compound|START_ENTITY has|nsubj|fertilization has|dobj|effect effect|nmod|soil soil|acl|nitrogen-fixing nitrogen-fixing|nmod|END_ENTITY	Nitrogen fertilization has a stronger effect on soil nitrogen-fixing bacterial communities than elevated atmospheric CO2 .
26261980	0	Nitrogen	109,117	CO2	57,60	Nitrogen	CO2	MESH:D009584	717	Chemical	Gene	Heterocycles|compound|START_ENTITY Correction|nmod|Heterocycles Correction|nmod|Catalyzed Catalyzed|compound|END_ENTITY	Correction to `` Theoretical Insights into Electrochemical CO2 Reduction Mechanisms Catalyzed by Surface-Bound Nitrogen Heterocycles '' .
26631712	0	Nitrogen	23,31	Cytochrome_P450	62,77	Nitrogen	Cytochrome P450	MESH:D009584	4051	Chemical	Gene	Oxidation|compound|START_ENTITY Oxidation|nmod|END_ENTITY	Sulfoxide , Sulfur , and Nitrogen Oxidation and Dealkylation by Cytochrome_P450 .
7766711	0	Nitrogen_monoxide	0,17	transferrin	45,56	Nitrogen monoxide	transferrin	MESH:D009569	7018	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|nmod|END_ENTITY	Nitrogen_monoxide decreases iron uptake from transferrin but does not mobilise iron from prelabelled neoplastic cells .
25098345	0	Nitroglycerin	98,111	Calcitonin_Gene-related_Peptide	41,72	Nitroglycerin	Calcitonin Gene-related Peptide	MESH:D005996	796	Chemical	Gene	Stimulated|nmod|START_ENTITY Stimulated|compound|END_ENTITY	Involvement of Anandamide Transporter in Calcitonin_Gene-related_Peptide Expression Stimulated by Nitroglycerin and Influence of ALDH2 Glu504Lys Polymorphism .
8170522	0	Nitroglycerin	0,13	calcitonin_gene-related_peptide	157,188	Nitroglycerin	calcitonin gene-related peptide	MESH:D005996	24241(Tax:10116)	Chemical	Gene	substitutes|amod|START_ENTITY induced|nsubj|substitutes induced|nmod|END_ENTITY	Nitroglycerin -LRB- exogenous nitric_oxide -RRB- substitutes for endothelium-derived nitric_oxide in potentiating vasorelaxations and cyclic_AMP elevations induced by calcitonin_gene-related_peptide -LRB- CGRP -RRB- in rat aorta .
6815044	0	Nitroglycerin	0,13	vasopressin	51,62	Nitroglycerin	vasopressin	MESH:D005996	551	Chemical	Gene	improves|nsubj|START_ENTITY improves|dobj|response response|acl|END_ENTITY	Nitroglycerin improves the hemodynamic response to vasopressin in portal hypertension .
1822450	0	Nitrogranulogen	0,15	IL-1	25,29	Nitrogranulogen	IL-1	MESH:D008466	3552	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|compound|END_ENTITY	Nitrogranulogen enhances IL-1 production but decreases cellular sensitivity to this cytokine .
736781	0	Nitroprusside	0,13	vasopressin	54,65	Nitroprusside	vasopressin	MESH:D009599	551	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|dobj|effects effects|nmod|END_ENTITY	Nitroprusside prevents adverse hemodynamic effects of vasopressin .
10779640	0	Nitrotyrosine	0,13	p53	69,72	Nitrotyrosine	p53	null	7157	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Nitrotyrosine in esophageal_squamous_cell_carcinoma and relevance to p53 expression .
17578961	0	Nitrous_oxide	0,13	methionine_synthase	33,52	Nitrous oxide	methionine synthase	MESH:D009609	81522(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|END_ENTITY	Nitrous_oxide decreases cortical methionine_synthase transiently but produces lasting memory_impairment in aged rats .
20473255	0	Nitrous_oxide	0,13	nNOS	38,42	Nitrous oxide	nNOS	MESH:D009609	24598(Tax:10116)	Chemical	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|END_ENTITY	Nitrous_oxide discretely up-regulates nNOS and p53 in neonatal rat brain .
15815293	0	Nitrous_oxide	0,13	substance_P_receptor	24,44	Nitrous oxide	substance P receptor	MESH:D009609	24807(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|END_ENTITY	Nitrous_oxide decreases substance_P_receptor binding in the rat spinal cord .
26507723	0	Nizatidine	14,24	MATE2K	28,34	Nizatidine	MATE2K	MESH:D016567	146802	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|compound|END_ENTITY	The Effect of Nizatidine , a MATE2K Selective Inhibitor , on the Pharmacokinetics and Pharmacodynamics of Metformin in Healthy Volunteers .
12923824	0	Nizatidine	0,10	leptin	47,53	Nizatidine	leptin	MESH:D016567	3952	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Nizatidine treatment and its relationship with leptin levels in patients with olanzapine-induced weight_gain .
24389490	0	Nobiletin	0,9	MMP-9	21,26	Nobiletin	MMP-9	MESH:C008661	4318	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Nobiletin suppresses MMP-9 expression through modulation of p38 MAPK activity in human dermal fibrobalsts .
23573124	0	Nobiletin	0,9	TrkB	56,60	Nobiletin	TrkB	MESH:C008661	25054(Tax:10116)	Chemical	Gene	Ameliorates|nsubj|START_ENTITY Ameliorates|nmod|END_ENTITY	Nobiletin Ameliorates the Deficits in Hippocampal BDNF , TrkB , and Synapsin_I Induced by Chronic Unpredictable Mild Stress .
23720425	0	Nociceptin	0,10	Rec8	19,23	Nociceptin	Rec8	MESH:C096012	56739(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|amod|END_ENTITY	Nociceptin induces Rec8 phosphorylation and meiosis in postnatal murine testes .
22240716	0	Nocistatin	0,10	c-Fos	35,40	Nocistatin	c-Fos	MESH:C111148	14281(Tax:10090)	Chemical	Gene	modulate|nsubj|START_ENTITY modulate|dobj|expression expression|amod|END_ENTITY	Nocistatin and nociceptin modulate c-Fos expression in the mice thalamus .
25833949	0	Nocodazole	152,162	EDD	0,3	Nocodazole	EDD	MESH:D015739	51366	Chemical	Gene	Response|nmod|START_ENTITY END_ENTITY|dep|Response	EDD , a Ubiquitin-protein Ligase of the N-end Rule Pathway , Associates with Spindle Assembly Checkpoint Components and Regulates the Mitotic Response to Nocodazole .
22294037	0	Nocodazole	0,10	ERK	25,28	Nocodazole	ERK	MESH:D015739	5594	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|activity activity|compound|END_ENTITY	Nocodazole increases the ERK activity to enhance MKP-1expression which inhibits p38 activation induced by TNF-a .
9575143	0	Nocodazole	0,10	T_cell_antigen_receptor	47,70	Nocodazole	T cell antigen receptor	MESH:D015739	6962	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Nocodazole inhibits signal transduction by the T_cell_antigen_receptor .
20128050	0	Nodosin	30,37	IL-2	56,60	Nodosin	IL-2	MESH:C548830	16183(Tax:10090)	Chemical	Gene	function|nmod|START_ENTITY function|nmod|END_ENTITY	Anti-inflammatory function of Nodosin via inhibition of IL-2 .
17698254	0	Noladin_ether	0,13	mu-opioid_receptor	52,70	Noladin ether	mu-opioid receptor	MESH:C424442	18390(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	Noladin_ether , a putative endocannabinoid , inhibits mu-opioid_receptor activation via CB2 cannabinoid receptors .
11985981	7	Nomega-nitro-L-arginine	904,927	NOS	940,943	Nomega-nitro-L-arginine	VIP	null	7432	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Under nonadrenergic noncholinergic -LRB- NANC -RRB- conditions , Nomega-nitro-L-arginine -LRB- L-NNA -RRB- , an NOS inhibitor , and VIP -LRB- 10-28 -RRB- , a vasoactive intestinal peptide -LRB- VIP -RRB- inhibitor , were added prior to electrical field stimulation .
14584105	0	Nomega-nitro-L-arginine_methyl_ester	8,44	c-Fos	80,85	Nomega-nitro-L-arginine methyl ester	c-Fos	null	314322(Tax:10116)	Chemical	Gene	influence|nsubj|START_ENTITY influence|dobj|END_ENTITY	Central Nomega-nitro-L-arginine_methyl_ester does not influence lithium-induced c-Fos and conditioned taste aversion .
12643903	0	Nonbenzamidine_isoxazoline	0,26	factor_Xa	42,51	Nonbenzamidine isoxazoline	factor Xa	null	2159	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Nonbenzamidine_isoxazoline derivatives as factor_Xa inhibitors .
12565931	0	Nonbenzamidine_tetrazole	0,24	factor_Xa	40,49	Nonbenzamidine tetrazole	factor Xa	null	2159	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Nonbenzamidine_tetrazole derivatives as factor_Xa inhibitors .
25704235	0	Nonivamide	0,10	let-7d	26,32	Nonivamide	let-7d	MESH:C040937	387247(Tax:10090)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Nonivamide enhances miRNA let-7d expression and decreases adipogenesis PPARy expression in 3T3-L1 cells .
24007511	0	Nonpeptidic_propargylamines	0,27	lysine_specific_demethylase_1	45,74	Nonpeptidic propargylamines	lysine specific demethylase 1	null	23028	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Nonpeptidic_propargylamines as inhibitors of lysine_specific_demethylase_1 -LRB- LSD1 -RRB- with cellular activity .
15647452	0	Nonylphenol	0,11	connexin_43	19,30	Nonylphenol	connexin 43	MESH:C025256	24392(Tax:10116)	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|levels levels|amod|END_ENTITY	Nonylphenol alters connexin_43 levels and connexin_43 phosphorylation via an inhibition of the p38-mitogen-activated_protein_kinase pathway .
24677730	0	Nonylphenol	0,11	cyclooxygenase-2	22,38	Nonylphenol	cyclooxygenase-2	MESH:C025256	19225(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Nonylphenol regulates cyclooxygenase-2 expression via Ros-activated NF-kB pathway in sertoli TM4 cells .
1680188	0	Noradrenaline	0,13	CA1	86,89	Noradrenaline	CA1	MESH:D009638	310218(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY participate|nsubj|receptors participate|nmod|END_ENTITY	Noradrenaline receptors participate in the regulation of GABAergic inhibition in area CA1 of the rat hippocampus .
10900341	0	Noradrenaline	0,13	ERK-2	41,46	Noradrenaline	ERK-2	MESH:D009638	5594	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Noradrenaline induces phosphorylation of ERK-2 in human peripheral blood mononuclear cells after induction of alpha -LRB- 1 -RRB- - adrenergic receptors .
20188818	0	Noradrenaline	0,13	Hsp72	54,59	Noradrenaline	Hsp72	MESH:D009638	3303	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Noradrenaline increases the expression and release of Hsp72 by human neutrophils .
20361987	0	Noradrenaline	0,13	IL-1beta	65,73	Noradrenaline	IL-1beta	MESH:D009638	24494(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Noradrenaline acting at beta-adrenoceptors induces expression of IL-1beta and its negative regulators IL-1ra and IL-1RII , and drives an overall anti-inflammatory phenotype in rat cortex .
19818755	0	Noradrenaline	0,13	IL-1ra	22,28	Noradrenaline	IL-1ra	MESH:D009638	60582(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Noradrenaline induces IL-1ra and IL-1_type_II_receptor expression in primary glial cells and protects against IL-1beta-induced neurotoxicity .
20361987	0	Noradrenaline	0,13	IL-1ra	102,108	Noradrenaline	IL-1ra	MESH:D009638	60582(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Noradrenaline acting at beta-adrenoceptors induces expression of IL-1beta and its negative regulators IL-1ra and IL-1RII , and drives an overall anti-inflammatory phenotype in rat cortex .
21195750	0	Noradrenaline	0,13	P2X3	27,31	Noradrenaline	P2X3	MESH:D009638	81739(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	Noradrenaline enhances ATP P2X3 receptor expression in dorsal root ganglion neurons of rats .
20595783	0	Noradrenaline	0,13	Per1	33,37	Noradrenaline	Per1	MESH:D009638	5187	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Noradrenaline induces clock gene Per1 mRNA expression in C6 glioma cells through beta -LRB- 2 -RRB- - adrenergic receptor coupled with protein kinase A - cAMP_response_element_binding_protein -LRB- PKA-CREB -RRB- and Src-tyrosine kinase - glycogen_synthase_kinase-3beta -LRB- Src-GSK-3beta -RRB- .
3715154	0	Noradrenaline	0,13	angiotensin_II	40,54	Noradrenaline	angiotensin II	MESH:D009638	24179(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|mediator mediator|nmod|END_ENTITY	Noradrenaline as a possible mediator of angiotensin_II induced fluid transport in rat ileum in vitro .
8670061	0	Noradrenaline	0,13	insulin	113,120	Noradrenaline	insulin	MESH:D009638	3630	Chemical	Gene	increases|nsubj|START_ENTITY increases|nmod|mechanism mechanism|amod|different different|nmod|that that|nmod|END_ENTITY	Noradrenaline increases glucose transport into brown adipocytes in culture by a mechanism different from that of insulin .
8741743	0	Noradrenaline	0,13	interleukin-1beta	76,93	Noradrenaline	interleukin-1beta	MESH:D009638	24494(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY induced|nsubj|release induced|nmod|END_ENTITY	Noradrenaline release in hypothalamus and ACTH secretion induced by central interleukin-1beta .
12887689	0	Noradrenaline	0,13	peroxisome_proliferator_activated_receptor_gamma	36,84	Noradrenaline	peroxisome proliferator activated receptor gamma	MESH:D009638	19016(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Noradrenaline induces expression of peroxisome_proliferator_activated_receptor_gamma -LRB- PPARgamma -RRB- in murine primary astrocytes and neurons .
11903811	0	Noradrenaline	0,13	prolactin	41,50	Noradrenaline	prolactin	MESH:D009638	443317(Tax:9940)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|secretion secretion|compound|END_ENTITY	Noradrenaline and dopamine regulation of prolactin secretion in sheep : role in prolactin homeostasis but not photoperiodism .
24670218	0	Norbin	33,39	mGluR5	44,50	Norbin	mGluR5	MESH:C109587	14805(Tax:10090)	Chemical	Gene	START_ENTITY|appos|protein protein|amod|END_ENTITY	Nanoscopic spine localization of Norbin , an mGluR5 accessory protein .
20813683	0	Norcantharidin	1,15	Cdc6	60,64	Norcantharidin	Cdc6	MESH:C069741	990	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	-LSB- Norcantharidin inhibits DNA replication initiation protein Cdc6 in cancer cells -RSB- .
18043130	0	Norcantharidin	0,14	Jun-N-terminal_kinase	39,60	Norcantharidin	Jun-N-terminal kinase	MESH:C069741	26419(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|amod|END_ENTITY	Norcantharidin induces anoikis through Jun-N-terminal_kinase activation in CT26 colorectal_cancer cells .
17562544	0	Nordihydroguaiaretic_acid	0,25	HER2	54,58	Nordihydroguaiaretic acid	HER2	MESH:D009637	2064	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Nordihydroguaiaretic_acid -LRB- NDGA -RRB- , an inhibitor of the HER2 and IGF-1_receptor tyrosine kinases , blocks the growth of HER2-overexpressing human breast_cancer cells .
23044922	0	Nordihydroguaiaretic_acid	0,25	NFATc1	40,46	Nordihydroguaiaretic acid	NFATc1	MESH:D009637	100361818	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Nordihydroguaiaretic_acid inhibition of NFATc1 suppresses osteoclastogenesis and arthritis bone_destruction in rats .
17919072	0	Nordihydroguaiaretic_acid	0,25	endothelial_nitric_oxide_synthase	36,69	Nordihydroguaiaretic acid	endothelial nitric oxide synthase	MESH:D009637	287024(Tax:9913)	Chemical	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	Nordihydroguaiaretic_acid increases endothelial_nitric_oxide_synthase expression via the transcription factor AP-1 .
25505619	0	Nordihydroguaiaretic_acid	0,25	hTRPA1	36,42	Nordihydroguaiaretic acid	hTRPA1	MESH:D009637	8989	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Nordihydroguaiaretic_acid activates hTRPA1 and modulates behavioral responses to noxious cold in mice .
22870140	0	Nordihydroguaiaretic_acid	0,25	p21	89,92	Nordihydroguaiaretic acid	p21	MESH:D009637	644914	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Nordihydroguaiaretic_acid inhibits growth of cervical_cancer SiHa cells by up-regulating p21 .
14499634	0	Nordihydroguaiaretic_acid	0,25	transforming_growth_factor-beta	52,83	Nordihydroguaiaretic acid	transforming growth factor-beta	MESH:D009637	7040	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Nordihydroguaiaretic_acid , an antioxidant , inhibits transforming_growth_factor-beta activity through the inhibition of Smad signaling pathway .
23843576	0	Norditropin_FlexPro	39,58	growth_hormone	113,127	Norditropin FlexPro	growth hormone	null	2688	Chemical	Gene	START_ENTITY|nmod|patients patients|acl|treated treated|nmod|END_ENTITY	Assessment of user-friendliness of the Norditropin_FlexPro for pediatric patients treated with recombinant human growth_hormone : results of an open-label user survey .
16876982	0	Norepinephrine	0,14	BDNF	23,27	Norepinephrine	BDNF	MESH:D009638	627	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Norepinephrine induces BDNF and activates the PI-3K and MAPK cascades in embryonic hippocampal neurons .
23844252	0	Norepinephrine	0,14	CCR2	59,63	Norepinephrine	CCR2	MESH:D009638	12772(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|expression expression|compound|END_ENTITY	Norepinephrine inhibits macrophage migration by decreasing CCR2 expression .
17726147	0	Norepinephrine	0,14	Elovl3	56,62	Norepinephrine	Elovl3	MESH:D009638	12686(Tax:10090)	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|amod|END_ENTITY	Norepinephrine and rosiglitazone synergistically induce Elovl3 expression in brown adipocytes .
16171784	0	Norepinephrine	0,14	HIF-1alpha	42,52	Norepinephrine	HIF-1alpha	MESH:D009638	15251(Tax:10090)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	Norepinephrine but not hypoxia stimulates HIF-1alpha gene expression in brown adipocytes .
15589045	0	Norepinephrine	0,14	IL-6	53,57	Norepinephrine	IL-6	MESH:D009638	16193(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|nmod|END_ENTITY	Norepinephrine in mice inhibits secretion of splenic IL-6 during the dark period but stimulates its secretion in the light period -- possible role of the corticosterone tone .
24026137	0	Norepinephrine	0,14	IL-6	67,71	Norepinephrine	IL-6	MESH:D009638	3569	Chemical	Gene	START_ENTITY|dep|synergize synergize|acl|inducing inducing|dobj|production production|compound|END_ENTITY	Norepinephrine and adenosine-5 ' - triphosphate synergize in inducing IL-6 production by human dermal microvascular endothelial cells .
8376550	0	Norepinephrine	0,14	IL-6	56,60	Norepinephrine	IL-6	MESH:D009638	24498(Tax:10116)	Chemical	Gene	peptide|amod|START_ENTITY peptide|dep|induce induce|dobj|secretion secretion|compound|END_ENTITY	Norepinephrine and vasoactive intestinal peptide induce IL-6 secretion by astrocytes : synergism with IL-1_beta and TNF_alpha .
12050158	0	Norepinephrine	0,14	I_kappa_B_alpha	25,40	Norepinephrine	I kappa B alpha	MESH:D009638	25493(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Norepinephrine increases I_kappa_B_alpha expression in astrocytes .
25590214	0	Norepinephrine	9,23	Insulin	85,92	Norepinephrine	Insulin	MESH:D009638	3630	Chemical	Gene	Concentration|compound|START_ENTITY Associated|nsubj|Concentration Associated|nmod|Clearance Clearance|compound|END_ENTITY	Arterial Norepinephrine Concentration is Inversely and Independently Associated With Insulin Clearance in Obese Individuals With Metabolic_Syndrome .
3532055	0	Norepinephrine	0,14	LH-RH	26,31	Norepinephrine	LH-RH	MESH:D009638	25194(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|amod|END_ENTITY	Norepinephrine stimulates LH-RH secretion into the hypophysial portal blood of the rat .
6368207	0	Norepinephrine	0,14	LH-RH	40,45	Norepinephrine	LH-RH	MESH:D009638	25194(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|releases releases|nmod|END_ENTITY	Norepinephrine induces releases of both LH-RH from the hypothalamus and LH from the rat pituitary in vitro .
20096362	0	Norepinephrine	0,14	NPY	30,33	Norepinephrine	NPY	MESH:D009638	396464(Tax:9031)	Chemical	Gene	alter|nsubj|START_ENTITY alter|dobj|expression expression|compound|END_ENTITY	Norepinephrine does not alter NPY and POMC mRNA expression in neonatal chicks .
12858360	0	Norepinephrine	0,14	P44	25,28	Norepinephrine	P44	MESH:D009638	10561	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Norepinephrine activates P44 and P42_MAPK in human prostate stromal and smooth muscle cells but not in epithelial cells .
18996182	0	Norepinephrine	0,14	VEGF	27,31	Norepinephrine	VEGF	MESH:D009638	7422	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	Norepinephrine upregulates VEGF , IL-8 , and IL-6 expression in human melanoma_tumor cell lines : implications for stress-related enhancement of tumor progression .
20715173	0	Norepinephrine	0,14	VEGF	23,27	Norepinephrine	VEGF	MESH:D009638	7422	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Norepinephrine induces VEGF expression and angiogenesis by a hypoxia-inducible_factor-1a protein-dependent mechanism .
8568924	0	Norepinephrine	0,14	corticotropin-releasing_factor	61,91	Norepinephrine	corticotropin-releasing factor	MESH:D009638	81648(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|nmod|END_ENTITY	Norepinephrine but not epinephrine stimulates the release of corticotropin-releasing_factor from in vitro superfused rat hypothalamus .
25520009	0	Norepinephrine	0,14	epithelial_sodium_channel	30,55	Norepinephrine	epithelial sodium channel	MESH:D009638	20276(Tax:10090)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Norepinephrine stimulates the epithelial_sodium_channel -LRB- ENaC -RRB- in cortical collecting duct cells via a2-adrenoceptors .
12807698	0	Norepinephrine	0,14	extraneuronal_monoamine_transporter	32,67	Norepinephrine	extraneuronal monoamine transporter	MESH:D009638	6581	Chemical	Gene	transport|amod|START_ENTITY transport|nmod|END_ENTITY	Norepinephrine transport by the extraneuronal_monoamine_transporter in human bronchial arterial smooth muscle cells .
8562484	0	Norepinephrine	0,14	fibroblast_growth_factor_2	44,70	Norepinephrine	fibroblast growth factor 2	MESH:D009638	54250(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|nmod|END_ENTITY	Norepinephrine stimulates the expression of fibroblast_growth_factor_2 in rat brown adipocyte primary culture .
10731686	0	Norepinephrine	0,14	interleukin-6	26,39	Norepinephrine	interleukin-6	MESH:D009638	24498(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Norepinephrine stimulates interleukin-6 mRNA expression in primary cultured rat hepatocytes .
14523327	0	Norepinephrine	0,14	interleukin-6	34,47	Norepinephrine	interleukin-6	MESH:D009638	24498(Tax:10116)	Chemical	Gene	infusion|amod|START_ENTITY increases|nsubj|infusion increases|xcomp|END_ENTITY	Norepinephrine infusion increases interleukin-6 in plasma and cerebrospinal fluid of brain-injured rats .
15358679	0	Norepinephrine	0,14	mitogen-activated_protein_kinase_phosphatase-1	28,74	Norepinephrine	mitogen-activated protein kinase phosphatase-1	MESH:D009638	114856(Tax:10116)	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|expression expression|amod|END_ENTITY	Norepinephrine induction of mitogen-activated_protein_kinase_phosphatase-1 expression in rat pinealocytes : distinct roles of alpha - and beta-adrenergic receptors .
1461360	0	Norepinephrine	0,14	neuropeptide_Y	107,121	Norepinephrine	neuropeptide Y	MESH:D009638	24604(Tax:10116)	Chemical	Gene	induced|advmod|START_ENTITY induced|nmod|END_ENTITY	Norepinephrine , dopamine , and 5-HT release from perfused hypothalamus of the rat during feeding induced by neuropeptide_Y .
8214124	0	Norepinephrine	0,14	neuropeptide_Y	93,107	Norepinephrine	neuropeptide Y	MESH:D009638	24604(Tax:10116)	Chemical	Gene	levels|amod|START_ENTITY levels|dep|role role|nmod|END_ENTITY	Norepinephrine levels in paraventricular nucleus of spontaneously hypertensive rats : role of neuropeptide_Y .
11244297	0	Norepinephrine	0,14	prolactin	109,118	Norepinephrine	prolactin	MESH:D009638	5617	Chemical	Gene	levels|amod|START_ENTITY levels|dep|influence influence|nmod|levels levels|compound|END_ENTITY	Norepinephrine dialysate levels in the hypothalamic paraventricular nucleus : influence on photoperiod-driven prolactin levels in the female siberian hamster .
15726019	0	Norepinephrine	0,14	thyrotropin-releasing_hormone	44,73	Norepinephrine	thyrotropin-releasing hormone	MESH:D009638	25569(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|release release|amod|END_ENTITY	Norepinephrine attenuates hypoxia-inhibited thyrotropin-releasing_hormone release in median eminence and paraventricular nucleus of rat hypothalamus .
15212408	0	Norepinephrine	0,14	tumor_necrosis_factor	45,66	Norepinephrine	tumor necrosis factor	MESH:D009638	7124	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Norepinephrine is a more potent inhibitor of tumor_necrosis_factor over a range of doses than dopamine .
10788502	0	Norepinephrine	0,14	vascular_endothelial_growth_factor	23,57	Norepinephrine	vascular endothelial growth factor	MESH:D009638	22339(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Norepinephrine induces vascular_endothelial_growth_factor gene expression in brown adipocytes through a beta - adrenoreceptor/cAMP/protein kinase A pathway involving Src but independently of Erk1/2 .
15166499	0	Norepinephrine	0,14	vascular_endothelial_growth_factor	27,61	Norepinephrine	vascular endothelial growth factor	MESH:D009638	83785(Tax:10116)	Chemical	Gene	upregulates|amod|START_ENTITY END_ENTITY|nsubj|upregulates	Norepinephrine upregulates vascular_endothelial_growth_factor in rat cardiac myocytes by a paracrine mechanism .
5637142	0	Norepinephrine	0,14	vasopressin	29,40	Norepinephrine	vasopressin	MESH:D009638	551	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Norepinephrine inhibition of vasopressin antidiuresis .
21568875	0	Norlichexanthone	0,16	adiponectin	83,94	Norlichexanthone	adiponectin	MESH:C568539	9370	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|secretion secretion|nmod|END_ENTITY	Norlichexanthone isolated from fungus P16 promotes the secretion and expression of adiponectin in cultured ST-13 adipocytes .
17146768	0	Nornicotine	0,11	dopamine_transporter	26,46	Nornicotine	dopamine transporter	MESH:C005311	24898(Tax:10116)	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Nornicotine inhibition of dopamine_transporter function in striatum via nicotinic receptor activation .
25897332	0	Noscapine	15,24	CYLD	0,4	Noscapine	CYLD	MESH:D009665	1540	Chemical	Gene	Activity|compound|START_ENTITY Activity|compound|END_ENTITY	CYLD Regulates Noscapine Activity in Acute_Lymphoblastic_Leukemia via a Microtubule-Dependent Mechanism .
16458614	0	Notoginsenoside_R1	0,18	PAI-1	69,74	Notoginsenoside R1	PAI-1	MESH:C072936	5054	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	Notoginsenoside_R1 from Panax notoginseng inhibits TNF-alpha-induced PAI-1 production in human aortic smooth muscle cells .
23406858	0	Novaferon	14,23	TNF-a	41,46	Novaferon	TNF-a	null	7124	Chemical	Gene	Mechanism|nmod|START_ENTITY Mechanism|nmod|END_ENTITY	-LSB- Mechanism of Novaferon on production of TNF-a by monocytes isolated from normal human peripheral blood -RSB- .
11853877	0	Novobiocin	0,10	CD38	33,37	Novobiocin	CD38	MESH:D009675	952	Chemical	Gene	inducer|nsubj|START_ENTITY inducer|nmod|END_ENTITY	Novobiocin is a novel inducer of CD38 on cells of the myelomonocytic lineage .
16880522	0	NuA4	36,40	Isw1	0,4	NuA4	Isw1	null	852547(Tax:4932)	Chemical	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	Isw1 functions in parallel with the NuA4 and Swr1 complexes in stress-induced gene repression .
12917332	0	NuA4	14,18	Yaf9	0,4	NuA4	Yaf9	null	855616(Tax:4932)	Chemical	Gene	subunit|amod|START_ENTITY END_ENTITY|appos|subunit	Yaf9 , a novel NuA4 histone acetyltransferase subunit , is required for the cellular response to spindle stress in yeast .
17681952	0	NuRD	59,63	Ikaros	32,38	NuRD	Ikaros	null	10320	Chemical	Gene	complex|compound|START_ENTITY END_ENTITY|nmod|complex	Predominant interaction of both Ikaros and Helios with the NuRD complex in immature thymocytes .
15516265	0	NuRD	68,72	MBD2/3	42,48	NuRD	MBD2/3	null	41151(Tax:7227)	Chemical	Gene	complex|compound|START_ENTITY END_ENTITY|nmod|complex	The Drosophila methyl-DNA binding protein MBD2/3 interacts with the NuRD complex via p55 and MI-2 .
15516265	0	NuRD	68,72	p55	85,88	NuRD	p55	null	41836(Tax:7227)	Chemical	Gene	complex|compound|START_ENTITY complex|nmod|END_ENTITY	The Drosophila methyl-DNA binding protein MBD2/3 interacts with the NuRD complex via p55 and MI-2 .
26539118	0	Nuciferine	0,10	Per-Arnt-Sim_kinase	25,44	Nuciferine	Per-Arnt-Sim kinase	MESH:C008692	23178	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	Nuciferine downregulates Per-Arnt-Sim_kinase expression during its alleviation of lipogenesis and inflammation on oleic_acid-induced hepatic_steatosis in HepG2 cells .
24911598	0	Nucleoside	50,60	Era	32,35	Nucleoside	Era	CHEBI:33838	26284	Chemical	Gene	Analogues|compound|START_ENTITY END_ENTITY|nmod|Analogues	HBIG Remains Significant in the Era of New Potent Nucleoside Analogues for Prophylaxis Against Hepatitis_B Recurrence After Liver Transplantation .
11682452	0	Nucleoside	0,10	adenosine_kinase	65,81	Nucleoside	adenosine kinase	CHEBI:33838	25368(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|dep|effects effects|nmod|potency potency|nmod|inhibitors inhibitors|amod|END_ENTITY	Nucleoside transporter subtype expression : effects on potency of adenosine_kinase inhibitors .
14581375	0	Nucleoside	0,10	hCNT1	74,79	Nucleoside	hCNT1	CHEBI:33838	9154	Chemical	Gene	profiles|amod|START_ENTITY profiles|nmod|cells cells|dep|role role|nmod|END_ENTITY	Nucleoside transporter profiles in human pancreatic_cancer cells : role of hCNT1 in 2 ' ,2 ' - difluorodeoxycytidine - induced cytotoxicity .
20883780	0	Nucleoside	0,10	hENT1	133,138	Nucleoside	hENT1	CHEBI:33838	2030	Chemical	Gene	profiles|amod|START_ENTITY show|nsubj|profiles show|xcomp|striking striking|nmod|predominance predominance|nmod|END_ENTITY	Nucleoside transporter expression profiles in human cardiac tissue show striking individual variability with overall predominance of hENT1 .
24281217	0	Nucleoside	20,30	hENT1	46,51	Nucleoside	hENT1	CHEBI:33838	2030	Chemical	Gene	Transporter|compound|START_ENTITY Transporter|appos|END_ENTITY	Human Equilibrative Nucleoside Transporter 1 -LRB- hENT1 -RRB- in Pancreatic_Adenocarcinoma : Towards Individualized Treatment Decisions .
2207073	0	Nucleoside	0,10	rhodopsin	25,34	Nucleoside	rhodopsin	CHEBI:33838	6010	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Nucleoside inhibitors of rhodopsin kinase .
8132589	0	Nucleoside_diphosphate	0,22	PuF	57,60	Nucleoside diphosphate	PuF	CHEBI:16862	4831	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Nucleoside_diphosphate kinase enzyme activity of NM23-H2 / PuF is not required for its DNA binding and in vitro transcriptional functions .
3038540	0	Nucleotide	0,10	ARG3	27,31	Nucleotide	ARG3	CHEBI:36976	853357(Tax:4932)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|gene gene|compound|END_ENTITY	Nucleotide sequence of the ARG3 gene of the yeast Saccharomyces_cerevisiae encoding ornithine_carbamoyltransferase .
15882992	0	Nucleotide	0,10	CARD12	22,28	Nucleotide	CARD12	CHEBI:36976	58484	Chemical	Gene	START_ENTITY|xcomp|binding binding|nmod|END_ENTITY	Nucleotide binding to CARD12 and its role in CARD12-mediated caspase-1 activation .
25474356	0	Nucleotide	57,67	CORIN	85,90	Nucleotide	CORIN	CHEBI:36976	10699	Chemical	Gene	Polymorphisms|compound|START_ENTITY Polymorphisms|nmod|Gene Gene|compound|END_ENTITY	Highly Significant Association between Two Common Single Nucleotide Polymorphisms in CORIN Gene and Preeclampsia in Caucasian Women .
3536508	0	Nucleotide	0,10	CTT1	52,56	Nucleotide	CTT1	CHEBI:36976	852979(Tax:4932)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|gene gene|compound|END_ENTITY	Nucleotide sequence of the Saccharomyces_cerevisiae CTT1 gene and deduced amino-acid sequence of yeast catalase_T .
19594134	0	Nucleotide	0,10	ClpB	74,78	Nucleotide	ClpB	CHEBI:36976	81570	Chemical	Gene	modulation|amod|START_ENTITY modulation|nmod|domain domain|nmod|END_ENTITY	Nucleotide binding and allosteric modulation of the second AAA + domain of ClpB probed by transient kinetic studies .
20085762	0	Nucleotide	0,10	ClpB	48,52	Nucleotide	ClpB	CHEBI:36976	81570	Chemical	Gene	START_ENTITY|dobj|requirements requirements|acl:relcl|render render|xcomp|active active|nsubj|END_ENTITY	Nucleotide utilization requirements that render ClpB active as a chaperone .
11861646	0	Nucleotide	10,20	Cystic_Fibrosis_Transmembrane_Conductance_Regulator	39,90	Nucleotide	Cystic Fibrosis Transmembrane Conductance Regulator	CHEBI:36976	1080	Chemical	Gene	Domain|compound|START_ENTITY Domain|nmod|END_ENTITY	The First Nucleotide Binding Domain of Cystic_Fibrosis_Transmembrane_Conductance_Regulator Is a Site of Stable Nucleotide Interaction , whereas the Second Is a Site of Rapid Turnover .
11861646	0	Nucleotide	111,121	Cystic_Fibrosis_Transmembrane_Conductance_Regulator	39,90	Nucleotide	Cystic Fibrosis Transmembrane Conductance Regulator	CHEBI:36976	1080	Chemical	Gene	Interaction|compound|START_ENTITY Site|nmod|Interaction Site|nsubj|Domain Domain|nmod|END_ENTITY	The First Nucleotide Binding Domain of Cystic_Fibrosis_Transmembrane_Conductance_Regulator Is a Site of Stable Nucleotide Interaction , whereas the Second Is a Site of Rapid Turnover .
26149808	0	Nucleotide	43,53	Cystic_Fibrosis_Transmembrane_Conductance_Regulator	76,127	Nucleotide	Cystic Fibrosis Transmembrane Conductance Regulator	D009711	1080	Chemical	Gene	Domain|compound|START_ENTITY Phenylalanine-508|nmod|Domain Deletion|nmod|Phenylalanine-508 Deletion|nmod|Exchange Exchange|compound|END_ENTITY	Deletion of Phenylalanine-508 in the First Nucleotide Binding Domain of the Cystic_Fibrosis_Transmembrane_Conductance_Regulator Increases Conformational Exchange and Inhibits Dimerization .
15019780	0	Nucleotide	0,10	DNA_gyrase	22,32	Nucleotide	DNA gyrase	CHEBI:36976	7153	Chemical	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	Nucleotide binding to DNA_gyrase causes loss of DNA wrap .
10973926	0	Nucleotide	0,10	DNA_polymerase_beta	51,70	Nucleotide	DNA polymerase beta	CHEBI:36976	5423	Chemical	Gene	synthesis|amod|START_ENTITY synthesis|nmod|END_ENTITY	Nucleotide excision repair DNA synthesis by excess DNA_polymerase_beta : a potential source of genetic instability in cancer cells .
1645230	0	Nucleotide	0,10	ERG12	27,32	Nucleotide	ERG12	CHEBI:36976	855248(Tax:4932)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|gene gene|compound|END_ENTITY	Nucleotide sequence of the ERG12 gene of Saccharomyces_cerevisiae encoding mevalonate_kinase .
11034564	0	Nucleotide	0,10	Fc_gamma_receptor_IIIB	29,51	Nucleotide	Fc gamma receptor IIIB	CHEBI:36976	2215	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Nucleotide sequence of a new Fc_gamma_receptor_IIIB allele that codes for a neutrophil antigen .
6393054	0	Nucleotide	0,10	GAL80	49,54	Nucleotide	GAL80	CHEBI:36976	854954(Tax:4932)	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Nucleotide sequence of the yeast regulatory gene GAL80 .
2989290	0	Nucleotide	0,10	GDH1	29,33	Nucleotide	GDH1	CHEBI:36976	854557(Tax:4932)	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|nsubj|sequence	Nucleotide sequence of yeast GDH1 encoding nicotinamide_adenine_dinucleotide_phosphate-dependent glutamate dehydrogenase .
27023180	0	Nucleotide	96,106	GIMAP5	126,132	Nucleotide	GIMAP5	D009711	317757(Tax:10090)	Chemical	Gene	Protein|compound|START_ENTITY Protein|appos|END_ENTITY	TCR and IL-7 Signaling Are Altered in the Absence of Functional GTPase of the Immune Associated Nucleotide Binding Protein 5 -LRB- GIMAP5 -RRB- .
3114236	0	Nucleotide	0,10	GLU1	45,49	Nucleotide	GLU1	CHEBI:36976	851013(Tax:4932)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Nucleotide sequence of the glucoamylase gene GLU1 in the yeast Saccharomycopsis fibuligera .
9714752	0	Nucleotide	0,10	HMGI-C	35,41	Nucleotide	HMGI-C	CHEBI:36976	395851(Tax:9031)	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|nsubj|sequence	Nucleotide sequence of the chicken HMGI-C cDNA and expression of the HMGI-C and IGF1 genes in autosomal dwarf chicken embryos .
16741950	0	Nucleotide	0,10	Hsp90	63,68	Nucleotide	Hsp90	CHEBI:36976	3320	Chemical	Gene	stimulation|amod|START_ENTITY controls|nsubj|stimulation controls|dobj|expression expression|amod|END_ENTITY	Nucleotide receptors stimulation by extracellular ATP controls Hsp90 expression through APE1/Ref -1 in thyroid_cancer cells : a novel tumorigenic pathway .
19133078	0	Nucleotide	0,10	Hsp90	28,33	Nucleotide	Hsp90	CHEBI:36976	38389(Tax:7227)	Chemical	Gene	diversity|amod|START_ENTITY diversity|nmod|gene gene|amod|END_ENTITY	Nucleotide diversity in the Hsp90 gene in natural populations of Drosophila_melanogaster from Australia .
23484535	3	Nucleotide	498,508	Hsp90	601,606	Nucleotide	Hsp90	CHEBI:36976	3320	Chemical	Gene	exchange|amod|START_ENTITY hydrolysis|nsubj|exchange hydrolysis|advcl|Hsp90 Hsp90|ccomp|drive drive|dobj|machine machine|amod|END_ENTITY	Nucleotide exchange and ATP hydrolysis by Hsp90 itself , with the assistance of cochaperones , drive the Hsp90 chaperone machine to bind , chaperone and release client proteins .
2987826	0	Nucleotide	0,10	IL-2_receptor	29,42	Nucleotide	IL-2 receptor	CHEBI:36976	3560	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|cDNA cDNA|compound|END_ENTITY	Nucleotide sequence of mouse IL-2_receptor cDNA and its comparison with the human IL-2_receptor sequence .
11118737	0	Nucleotide	0,10	L1_and_part_of_P1	23,40	Nucleotide	L1 and part of P1	CHEBI:36976	3897	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Nucleotide sequence of L1_and_part_of_P1 of hexon gene of fowl adenovirus associated with hydropericardium_hepatitis_syndrome differs with the corresponding region of other fowl adenoviruses .
6297759	0	Nucleotide	0,10	LEU2	29,33	Nucleotide	LEU2	CHEBI:36976	850342(Tax:4932)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Nucleotide sequence of yeast LEU2 shows 5 ' - noncoding region has sequences cognate to leucine .
19759005	0	Nucleotide	0,10	Lhs1p	22,27	Nucleotide	Lhs1p	CHEBI:36976	853789(Tax:4932)	Chemical	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	Nucleotide binding by Lhs1p is essential for its nucleotide exchange activity and for function in vivo .
26827181	0	Nucleotide	7,17	MORC4	35,40	Nucleotide	MORC4	D009711	79710	Chemical	Gene	Polymorphisms|compound|START_ENTITY Polymorphisms|nmod|END_ENTITY	Single Nucleotide Polymorphisms in MORC4 , CD14 , and TLR4 Are Related to Outcome of Allogeneic Stem Cell Transplantation .
2374694	0	Nucleotide	0,10	MyD88	54,59	Nucleotide	MyD88	CHEBI:36976	17874(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Nucleotide sequence and expression of a cDNA encoding MyD88 , a novel myeloid differentiation primary response gene induced by IL6 .
12163030	0	Nucleotide	0,10	P-glycoprotein	117,131	Nucleotide	P-glycoprotein	CHEBI:36976	5243	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Nucleotide triphosphatase activity of the N-terminal nucleotide-binding domains of the multidrug resistance proteins P-glycoprotein and MRP1 .
23911869	0	Nucleotide	0,10	P2RX7	20,25	Nucleotide	P2RX7	CHEBI:36976	18439(Tax:10090)	Chemical	Gene	stimulation|amod|START_ENTITY stimulation|compound|END_ENTITY	Nucleotide receptor P2RX7 stimulation enhances LPS-induced interferon-b production in murine macrophages .
10731710	0	Nucleotide	0,10	PBII	28,32	Nucleotide	PBII	CHEBI:36976	10879	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|nsubj|sequence	Nucleotide sequence of gene PBII encoding salivary proline-rich protein P-B .
2687114	0	Nucleotide	0,10	PUT4	52,56	Nucleotide	PUT4	CHEBI:36976	854530(Tax:4932)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|gene gene|compound|END_ENTITY	Nucleotide sequence of the Saccharomyces_cerevisiae PUT4 proline-permease-encoding gene : similarities between CAN1 , HIP1 and PUT4 permeases .
8616155	0	Nucleotide	0,10	PetM	27,31	Nucleotide	PetM	CHEBI:36976	5719581(Tax:3055)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|gene gene|compound|END_ENTITY	Nucleotide sequence of the PetM gene encoding a 4 kDa subunit of the cytochrome b6f complex from Chlamydomonas_reinhardtii .
3912171	0	Nucleotide	0,10	RAD10	27,32	Nucleotide	RAD10	CHEBI:36976	854878(Tax:4932)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|gene gene|compound|END_ENTITY	Nucleotide sequence of the RAD10 gene of Saccharomyces_cerevisiae .
7844569	0	Nucleotide	0,10	RNA1	45,49	Nucleotide	RNA1	CHEBI:36976	956647(Tax:12280)	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|nsubj|sequence	Nucleotide sequence of tomato_ringspot_virus RNA1 .
2123556	0	Nucleotide	0,10	SPO13	45,50	Nucleotide	SPO13	CHEBI:36976	7008992(Tax:10685)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Nucleotide sequence and promoter analysis of SPO13 , a meiosis-specific gene of Saccharomyces_cerevisiae .
6300785	0	Nucleotide	0,10	SUC2	33,37	Nucleotide	SUC2	CHEBI:36976	854644(Tax:4932)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|gene gene|compound|END_ENTITY	Nucleotide sequence of the yeast SUC2 gene for invertase .
20221813	0	Nucleotide	0,10	Smad3	30,35	Nucleotide	Smad3	CHEBI:36976	610902(Tax:9615)	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Nucleotide sequence of canine Smad3 .
2524424	0	Nucleotide	0,10	Stp-1	27,32	Nucleotide	Stp-1	CHEBI:36976	24839(Tax:10116)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|gene gene|compound|END_ENTITY	Nucleotide sequence of the Stp-1 gene coding for rat spermatid nuclear transition protein 1 -LRB- TP1 -RRB- : homology with protamine P1 and assignment of the mouse Stp-1 gene to chromosome 1 .
10508608	0	Nucleotide	0,10	TAP	22,25	Nucleotide	TAP	CHEBI:36976	6890	Chemical	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	Nucleotide binding by TAP mediates association with peptide and release of assembled MHC class I molecules .
26082030	0	Nucleotide	19,29	Ucp2	41,45	Nucleotide	Ucp2	D009711	7351	Chemical	Gene	Binding|compound|START_ENTITY Binding|nmod|END_ENTITY	Anion Transport or Nucleotide Binding by Ucp2 Is Indispensable for Ucp2-Mediated Efferocytosis .
26082030	0	Nucleotide	19,29	Ucp2	41,45	Nucleotide	Ucp2	D009711	7351	Chemical	Gene	Binding|compound|START_ENTITY Binding|nmod|END_ENTITY	Anion Transport or Nucleotide Binding by Ucp2 Is Indispensable for Ucp2-Mediated Efferocytosis .
26242196	0	Nucleotide	31,41	Ucp2	53,57	Nucleotide	Ucp2	D009711	7351	Chemical	Gene	Binding|compound|START_ENTITY Binding|nmod|END_ENTITY	Erratum to : Anion Transport or Nucleotide Binding by Ucp2 Is Indispensable for Ucp2-Mediated Efferocytosis .
3838518	0	Nucleotide	0,10	VIP	60,63	Nucleotide	VIP	CHEBI:36976	7432	Chemical	Gene	divergence|amod|START_ENTITY divergence|nmod|END_ENTITY	Nucleotide sequence divergence and functional constraint in VIP precursor mRNA evolution between human and rat .
3921964	0	Nucleotide	0,10	adenine_phosphoribosyltransferase	50,83	Nucleotide	adenine phosphoribosyltransferase	CHEBI:36976	11821(Tax:10090)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|gene gene|compound|END_ENTITY	Nucleotide sequence and organization of the mouse adenine_phosphoribosyltransferase gene : presence of a coding region common to animal and bacterial phosphoribosyltransferases that has a variable intron/exon arrangement .
19544207	0	Nucleotide	0,10	apolipoprotein-B	52,68	Nucleotide	apolipoprotein-B	CHEBI:36976	100519252	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Nucleotide sequence and association analysis of pig apolipoprotein-B and LDL-receptor genes .
1748314	0	Nucleotide	0,10	apolipoprotein_H	62,78	Nucleotide	apolipoprotein H	CHEBI:36976	350	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Nucleotide sequence and expression of the human gene encoding apolipoprotein_H -LRB- beta 2-glycoprotein I -RRB- .
20444229	0	Nucleotide	0,10	atToc33	84,91	Nucleotide	atToc33	CHEBI:36976	839248(Tax:3702)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Nucleotide binding and dimerization at the chloroplast pre-protein import receptor , atToc33 , are not essential in vivo but do increase import efficiency .
11340353	0	Nucleotide	0,10	beta-defensin-1	42,57	Nucleotide	beta-defensin-1	CHEBI:36976	83687(Tax:10116)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Nucleotide sequence and expression of rat beta-defensin-1 : its significance in diabetic_rodent_models .
3536508	0	Nucleotide	0,10	catalase_T	103,113	Nucleotide	catalase T	CHEBI:36976	852979(Tax:4932)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Nucleotide sequence of the Saccharomyces_cerevisiae CTT1 gene and deduced amino-acid sequence of yeast catalase_T .
1517170	0	Nucleotide	0,10	chloramphenicol_acetyltransferase	54,87	Nucleotide	chloramphenicol acetyltransferase	CHEBI:36976	4594953(Tax:1280)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Nucleotide sequence and structural relationships of a chloramphenicol_acetyltransferase encoded by the plasmid pSCS6 from Staphylococcus_aureus .
17195847	0	Nucleotide	0,10	chloride_transporter_ClC-5	62,88	Nucleotide	chloride transporter ClC-5	CHEBI:36976	1184	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Nucleotide recognition by the cytoplasmic domain of the human chloride_transporter_ClC-5 .
9163522	0	Nucleotide	0,10	cytosolic_phosphoenolpyruvate_carboxykinase	54,97	Nucleotide	cytosolic phosphoenolpyruvate carboxykinase	CHEBI:36976	396458(Tax:9031)	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|nsubj|sequence	Nucleotide sequence of the promoter region of chicken cytosolic_phosphoenolpyruvate_carboxykinase gene .
1381582	0	Nucleotide	0,10	cytosolic_serine_hydroxymethyltransferase	67,108	Nucleotide	cytosolic serine hydroxymethyltransferase	CHEBI:36976	100009405(Tax:9986)	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|nsubj|sequence	Nucleotide sequence and expression of a cDNA encoding rabbit liver cytosolic_serine_hydroxymethyltransferase .
1612412	0	Nucleotide	0,10	dehydrogenase	47,60	Nucleotide	dehydrogenase	CHEBI:36976	3718867(Tax:272943)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|gene gene|compound|END_ENTITY	Nucleotide sequence of the methoxyneurosporene dehydrogenase gene from Rhodobacter_sphaeroides : comparison with other bacterial carotenoid dehydrogenases .
1406603	0	Nucleotide	0,10	deoxycytidine_kinase	32,52	Nucleotide	deoxycytidine kinase	CHEBI:36976	1633	Chemical	Gene	START_ENTITY|dobj|specificity specificity|nmod|END_ENTITY	Nucleotide specificity of human deoxycytidine_kinase .
7706167	0	Nucleotide	0,10	dihydrofolate_reductase	95,118	Nucleotide	dihydrofolate reductase	CHEBI:36976	1719	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|nsubj|sequence	Nucleotide sequence and genetic analysis of the type Ib trimethoprim-resistant , Tn4132-encoded dihydrofolate_reductase .
7764604	0	Nucleotide	0,10	epidermal_growth_factor_receptor	58,90	Nucleotide	epidermal growth factor receptor	CHEBI:36976	13649(Tax:10090)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Nucleotide sequence of the C-terminal region of the mouse epidermal_growth_factor_receptor and expression in teratoma-derived cell lines with increased tumorigenic properties .
1420369	0	Nucleotide	0,10	erythropoietin	27,41	Nucleotide	erythropoietin	CHEBI:36976	24335(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Nucleotide sequence of rat erythropoietin .
2840246	0	Nucleotide	0,10	follicle-stimulating_hormone_beta-subunit	43,84	Nucleotide	follicle-stimulating hormone beta-subunit	CHEBI:36976	281171(Tax:9913)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Nucleotide sequence of the bovine gene for follicle-stimulating_hormone_beta-subunit .
6281465	0	Nucleotide	0,10	gag	63,66	Nucleotide	gag	CHEBI:36976	1491923(Tax:11886)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|gene gene|compound|END_ENTITY	Nucleotide sequence of the 5 ' noncoding region and part of the gag gene of Rous_sarcoma_virus .
1954256	0	Nucleotide	0,10	glutathione_S-transferase	34,59	Nucleotide	glutathione S-transferase	CHEBI:36976	395863(Tax:9031)	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|nsubj|sequence	Nucleotide sequence of a class mu glutathione_S-transferase from chicken liver .
16413296	0	Nucleotide	0,10	hGBP1	93,98	Nucleotide	hGBP1	CHEBI:36976	2633	Chemical	Gene	START_ENTITY|dobj|activity activity|nmod|END_ENTITY	Nucleotide binding and self-stimulated GTPase activity of human guanylate-binding_protein_1 -LRB- hGBP1 -RRB- .
1406698	0	Nucleotide	0,10	insulin-like_growth_factor_I	53,81	Nucleotide	insulin-like growth factor I	CHEBI:36976	3479	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Nucleotide sequence and tissue distribution of three insulin-like_growth_factor_I prohormones in salmon .
3017306	0	Nucleotide	0,10	lactate_dehydrogenase-A	63,86	Nucleotide	lactate dehydrogenase-A	CHEBI:36976	16828(Tax:10090)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|gene gene|compound|END_ENTITY	Nucleotide sequence of the putative regulatory region of mouse lactate_dehydrogenase-A gene .
7013987	0	Nucleotide	0,10	lexA	27,31	Nucleotide	lexA	CHEBI:36976	20466968	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|gene gene|compound|END_ENTITY	Nucleotide sequence of the lexA gene of E. _ coli .
2578462	0	Nucleotide	0,10	metallothionein	51,66	Nucleotide	metallothionein	CHEBI:36976	326270(Tax:7227)	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Nucleotide sequence and expression of a Drosophila metallothionein .
1645230	0	Nucleotide	0,10	mevalonate_kinase	75,92	Nucleotide	mevalonate kinase	CHEBI:36976	855248(Tax:4932)	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|nsubj|sequence	Nucleotide sequence of the ERG12 gene of Saccharomyces_cerevisiae encoding mevalonate_kinase .
2958911	0	Nucleotide	0,10	mitochondrial_ATPase	44,64	Nucleotide	mitochondrial ATPase	CHEBI:36976	514	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|END_ENTITY	Nucleotide effects on kinetic properties of mitochondrial_ATPase .
20563633	0	Nucleotide	0,10	multidrug_resistance_protein_3	32,62	Nucleotide	multidrug resistance protein 3	CHEBI:36976	5244	Chemical	Gene	START_ENTITY|xcomp|binding binding|nmod|END_ENTITY	Nucleotide binding to the human multidrug_resistance_protein_3 , MRP3 .
2676972	0	Nucleotide	0,10	mutL	50,54	Nucleotide	mutL	CHEBI:36976	1255885(Tax:99287)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|gene gene|compound|END_ENTITY	Nucleotide sequence of the Salmonella_typhimurium mutL gene required for mismatch repair : homology of MutL to HexB of Streptococcus_pneumoniae and to PMS1 of the yeast Saccharomyces_cerevisiae .
2989554	0	Nucleotide	0,10	myc	36,39	Nucleotide	myc	CHEBI:36976	4609	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|gene gene|compound|END_ENTITY	Nucleotide sequence of a transduced myc gene from a defective feline_leukemia_provirus .
1390932	0	Nucleotide	0,10	myosin	47,53	Nucleotide	myosin	CHEBI:36976	79784	Chemical	Gene	changes|amod|START_ENTITY changes|nmod|structure structure|amod|END_ENTITY	Nucleotide - and temperature-induced changes in myosin subfragment-1 structure .
21185304	0	Nucleotide	0,10	myosin	88,94	Nucleotide	myosin	CHEBI:36976	79784	Chemical	Gene	thermodynamics|amod|START_ENTITY reveal|nsubj|thermodynamics reveal|ccomp|relates relates|dobj|speed speed|compound|END_ENTITY	Nucleotide pocket thermodynamics measured by EPR reveal how energy partitioning relates myosin speed to efficiency .
2938184	0	Nucleotide	0,10	myosin	42,48	Nucleotide	myosin	CHEBI:36976	79784	Chemical	Gene	START_ENTITY|acl|trapping trapping|nmod|site site|nmod|END_ENTITY	Nucleotide trapping at the ATPase site of myosin subfragment 1 by a new interthiol crosslinking .
6453130	0	Nucleotide	0,10	myosin	44,50	Nucleotide	myosin	CHEBI:36976	79784	Chemical	Gene	induced|nsubj|START_ENTITY induced|dobj|interaction interaction|nmod|END_ENTITY	Nucleotide induced head-head interaction in myosin .
3623105	0	Nucleotide	0,10	nahH	43,47	Nucleotide	nahH	CHEBI:36976	1343205(Tax:303)	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Nucleotide sequence and expression of gene nahH of plasmid NAH7 and homology with gene xylE of TOL pWWO .
12403170	0	Nucleotide	0,10	nonA	46,50	Nucleotide	nonA	CHEBI:36976	6631485(Tax:7244)	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Nucleotide and repeat length variation at the nonA gene of the Drosophila_virilis group species and its effects on male courtship song .
6287572	0	Nucleotide	0,10	p21	27,30	Nucleotide	p21	CHEBI:36976	644914	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|protein protein|amod|END_ENTITY	Nucleotide sequence of the p21 transforming protein of Harvey murine_sarcoma_virus .
9374488	0	Nucleotide	0,10	p21	58,61	Nucleotide	p21	CHEBI:36976	644914	Chemical	Gene	changes|amod|START_ENTITY changes|nmod|ras ras|amod|END_ENTITY	Nucleotide hydrolysis-dependent conformational changes in p21 -LRB- ras -RRB- as studied using ESR spectroscopy .
10029670	0	Nucleotide	0,10	p53	28,31	Nucleotide	p53	CHEBI:36976	22060(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Nucleotide variation in the p53 tumor-suppressor gene of voles from Chernobyl , Ukraine .
12034505	0	Nucleotide	0,10	p53	27,30	Nucleotide	p53	CHEBI:36976	7157	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|cDNA cDNA|compound|END_ENTITY	Nucleotide sequence of the p53 cDNA of beluga whale -LRB- Delphinapterus leucas -RRB- .
1565474	0	Nucleotide	0,10	p53	69,72	Nucleotide	p53	CHEBI:36976	7157	Chemical	Gene	START_ENTITY|nmod|region region|nmod|gene gene|compound|END_ENTITY	Nucleotide sequence polymorphism in a hotspot mutation region of the p53 gene .
24462112	0	Nucleotide	0,10	p53	76,79	Nucleotide	p53	CHEBI:36976	7157	Chemical	Gene	biosynthetic|amod|START_ENTITY GMP_synthase|amod|biosynthetic relay|nsubj|GMP_synthase relay|nmod|stabilization stabilization|compound|END_ENTITY	Nucleotide biosynthetic enzyme GMP_synthase is a TRIM21-controlled relay of p53 stabilization .
8722575	0	Nucleotide	0,10	p53	43,46	Nucleotide	p53	CHEBI:36976	100062044(Tax:9796)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|gene gene|compound|END_ENTITY	Nucleotide sequence of exons 5 to 9 of the p53 tumour-suppressor gene of the horse -LRB- Equus_caballus -RRB- .
2986678	0	Nucleotide	0,10	phenylalanine_hydroxylase	94,119	Nucleotide	phenylalanine hydroxylase	CHEBI:36976	5053	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Nucleotide sequence of a full-length complementary DNA clone and amino_acid sequence of human phenylalanine_hydroxylase .
1431809	0	Nucleotide	0,10	polyhedrin	56,66	Nucleotide	polyhedrin	CHEBI:36976	2715838(Tax:10454)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|gene gene|compound|END_ENTITY	Nucleotide sequence and transcriptional analysis of the polyhedrin gene of Spodoptera_exigua_nuclear_polyhedrosis_virus .
18639177	0	Nucleotide	0,10	polyhedrin	27,37	Nucleotide	polyhedrin	CHEBI:36976	1403840(Tax:46015)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|gene gene|compound|END_ENTITY	Nucleotide sequence of the polyhedrin gene of Autographa_californica_nuclear_polyhedrosis_virus .
1309675	0	Nucleotide	0,10	prothrombin	23,34	Nucleotide	prothrombin	CHEBI:36976	2147	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|gene gene|compound|END_ENTITY	Nucleotide sequence of prothrombin gene in abnormal prothrombin-producing hepatocellular_carcinoma cell lines .
3816785	0	Nucleotide	0,10	ribosomal_protein_L31	52,73	Nucleotide	ribosomal protein L31	CHEBI:36976	64298(Tax:10116)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Nucleotide sequence of cloned cDNA specific for rat ribosomal_protein_L31 .
3753935	0	Nucleotide	0,10	ribosomal_protein_L35a	52,74	Nucleotide	ribosomal protein L35a	CHEBI:36976	57809(Tax:10116)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Nucleotide sequence of cloned cDNA specific for rat ribosomal_protein_L35a .
3838984	0	Nucleotide	0,10	ribosomal_protein_S11	52,73	Nucleotide	ribosomal protein S11	CHEBI:36976	81774(Tax:10116)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Nucleotide sequence of cloned cDNA specific for rat ribosomal_protein_S11 .
2033077	0	Nucleotide	0,10	threonyl-tRNA_synthetase	52,76	Nucleotide	threonyl-tRNA synthetase	CHEBI:36976	6897	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Nucleotide and deduced amino_acid sequence of human threonyl-tRNA_synthetase reveals extensive homology to the Escherichia_coli and yeast enzymes .
6842679	0	Nucleotide	0,10	thymidine_kinase	42,58	Nucleotide	thymidine kinase	CHEBI:36976	3707550(Tax:10245)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|gene gene|compound|END_ENTITY	Nucleotide sequence of the vaccinia_virus thymidine_kinase gene and the nature of spontaneous frameshift mutations .
7916704	0	Nucleotide	0,10	thyroid_peroxidase	47,65	Nucleotide	thyroid peroxidase	CHEBI:36976	22018(Tax:10090)	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|nsubj|sequence	Nucleotide sequence of the cDNA encoding mouse thyroid_peroxidase .
1420315	0	Nucleotide	0,10	transforming_growth_factor-alpha	53,85	Nucleotide	transforming growth factor-alpha	CHEBI:36976	21802(Tax:10090)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Nucleotide sequence and tissue distribution of mouse transforming_growth_factor-alpha .
1909058	0	Nucleotide	0,10	tyrosinase	42,52	Nucleotide	tyrosinase	CHEBI:36976	7299	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Nucleotide sequence of the putative human tyrosinase pseudogene .
7873609	0	Nucleotide	0,10	uromodulin	48,58	Nucleotide	uromodulin	CHEBI:36976	22242(Tax:10090)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Nucleotide sequence and peptide motifs of mouse uromodulin -LRB- Tamm-Horsfall protein -RRB- -- the most abundant protein in mammalian urine .
12069081	0	Nucleotide	0,10	vascular_endothelial_growth_factor	49,83	Nucleotide	vascular endothelial growth factor	CHEBI:36976	7422	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Nucleotide sequence and expression of the feline vascular_endothelial_growth_factor .
7841203	0	Nucleotide	0,10	vascular_endothelial_growth_factor	50,84	Nucleotide	vascular endothelial growth factor	CHEBI:36976	7422	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Nucleotide sequence and expression of the porcine vascular_endothelial_growth_factor .
3371665	0	Nucleotide	0,10	vimentin	33,41	Nucleotide	vimentin	CHEBI:36976	7431	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|gene gene|compound|END_ENTITY	Nucleotide sequence of the human vimentin gene and regulation of its transcription in tissues and cultured cells .
3125410	0	Nucleotide	0,10	zeste	51,56	Nucleotide	zeste	CHEBI:36976	31230(Tax:7227)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Nucleotide sequence and structural analysis of the zeste locus of Drosophila_melanogaster .
22872685	0	Nutlin	36,42	MDM2	75,79	Nutlin	MDM2	CHEBI:46741	4193	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|nmod|END_ENTITY	Combination treatment in vitro with Nutlin , a small-molecule antagonist of MDM2 , and pegylated interferon-a 2a specifically targets JAK2V617F-positive polycythemia vera cells .
24867259	0	Nutlin-3	0,8	BCL2A1	17,23	Nutlin-3	BCL2A1	MESH:C482205	597	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Nutlin-3 induces BCL2A1 expression by activating ELK1 through the mitochondrial p53-ROS-ERK1 / 2 pathway .
24867259	0	Nutlin-3	0,8	ELK1	49,53	Nutlin-3	ELK1	MESH:C482205	2002	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|activating activating|dobj|END_ENTITY	Nutlin-3 induces BCL2A1 expression by activating ELK1 through the mitochondrial p53-ROS-ERK1 / 2 pathway .
24366007	0	Nutlin-3	0,8	HO-1	17,21	Nutlin-3	HO-1	MESH:C482205	3162	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Nutlin-3 induces HO-1 expression by activating JNK in a transcription-independent manner of p53 .
19696166	0	Nutlin-3	0,8	Hdm2	13,17	Nutlin-3	Hdm2	MESH:C482205	4193	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Nutlin-3 , an Hdm2 antagonist , inhibits tumor adaptation to hypoxia by stimulating the FIH-mediated inactivation of HIF-1alpha .
24366007	0	Nutlin-3	0,8	JNK	47,50	Nutlin-3	JNK	MESH:C482205	5599	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|activating activating|dobj|END_ENTITY	Nutlin-3 induces HO-1 expression by activating JNK in a transcription-independent manner of p53 .
20588277	0	Nutlin-3	0,8	MDM2	42,46	Nutlin-3	MDM2	MESH:C482205	4193	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Nutlin-3 , the small-molecule inhibitor of MDM2 , promotes senescence and radiosensitises laryngeal_carcinoma cells harbouring wild-type p53 .
23187459	0	Nutlin-3	0,8	MDM2	27,31	Nutlin-3	MDM2	MESH:C482205	17246(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Nutlin-3 , a small-molecule MDM2 inhibitor , sensitizes Caki cells to TRAIL-induced apoptosis through p53-mediated PUMA upregulation and ROS-mediated DR5 upregulation .
23776060	0	Nutlin-3	27,35	MDM2	92,96	Nutlin-3	MDM2	MESH:C482205	4193	Chemical	Gene	responsive|amod|START_ENTITY site|amod|responsive site|nmod|domain domain|nmod|END_ENTITY	Identification of a second Nutlin-3 responsive interaction site in the N-terminal domain of MDM2 using hydrogen/deuterium exchange mass spectrometry .
25067787	0	Nutlin-3	49,57	MDM2	101,105	Nutlin-3	MDM2	MESH:C482205	4193	Chemical	Gene	cells|nmod|START_ENTITY induction|nmod|cells induction|dep|strategy strategy|acl|based based|nmod|antagonism antagonism|compound|END_ENTITY	Senescence induction in renal_carcinoma cells by Nutlin-3 : a potential therapeutic strategy based on MDM2 antagonism .
21753157	0	Nutlin-3	0,8	TCL1	54,58	Nutlin-3	TCL1	MESH:C482205	8115	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|nmod|END_ENTITY	Nutlin-3 downregulates the expression of the oncogene TCL1 in primary B chronic lymphocytic leukemic cells .
23523610	0	Nutlin-3a	29,38	p53	14,17	Nutlin-3a	p53	MESH:C482205	7157	Chemical	Gene	pathway|nmod|START_ENTITY pathway|compound|END_ENTITY	Activation of p53 pathway by Nutlin-3a inhibits the expression of the therapeutic target a5 integrin in colon_cancer cells .
18691119	0	Nutlins	19,26	MDM2	4,8	Nutlins	MDM2	CHEBI:46741	17246(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|inhibitor inhibitor|compound|END_ENTITY	The MDM2 inhibitor Nutlins as an innovative therapeutic tool for the treatment of haematological_malignancies .
22246807	0	O	47,48	Heat_shock_transcription_factor_1	0,33	O	Heat shock transcription factor 1	null	3297	Chemical	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Heat_shock_transcription_factor_1 inhibits H O - induced cardiomyocyte_death through suppression of high-mobility_group_box_1 .
16000877	0	O-GlcNAc	0,8	IRS-1	25,30	O-GlcNAc	IRS-1	null	25467(Tax:10116)	Chemical	Gene	modification|amod|START_ENTITY modification|nmod|END_ENTITY	O-GlcNAc modification on IRS-1 and Akt2 by PUGNAc inhibits their phosphorylation and induces insulin resistance in rat primary adipocytes .
21904602	0	O-GlcNAc	0,8	NFkB	25,29	O-GlcNAc	NFkB	null	309165(Tax:10116)	Chemical	Gene	modification|amod|START_ENTITY modification|nmod|END_ENTITY	O-GlcNAc modification of NFkB p65 inhibits TNF-a-induced inflammatory mediator expression in rat aortic smooth muscle cells .
19132533	0	O-GlcNAc	0,8	vimentin	38,46	O-GlcNAc	vimentin	null	420519(Tax:9031)	Chemical	Gene	modification|amod|START_ENTITY modification|nmod|END_ENTITY	O-GlcNAc modification of radial glial vimentin filaments in the developing chick brain .
24744147	0	O-GlcNAcylation	0,15	b-catenin	27,36	O-GlcNAcylation	b-catenin	null	1499	Chemical	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	O-GlcNAcylation stabilizes b-catenin through direct competition with phosphorylation at threonine 41 .
12684542	0	O-N-acetylglucosamine	33,54	serum_response_factor	71,92	O-N-acetylglucosamine	serum response factor	null	6722	Chemical	Gene	modification|amod|START_ENTITY modification|nmod|END_ENTITY	Identification of novel sites of O-N-acetylglucosamine modification of serum_response_factor using quadrupole time-of-flight mass spectrometry .
19700318	0	O-Spiro_C-aryl_glucosides	0,25	sodium-dependent_glucose_co-transporter_2	35,76	O-Spiro C-aryl glucosides	sodium-dependent glucose co-transporter 2	null	6524	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	O-Spiro_C-aryl_glucosides as novel sodium-dependent_glucose_co-transporter_2 -LRB- SGLT2 -RRB- inhibitors .
17440500	0	O-acetyl	63,71	MBOAT1	90,96	O-acetyl	MBOAT1	null	154141	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A t -LRB- 4 ; 6 -RRB- -LRB- q12 ; p23 -RRB- translocation disrupts a membrane-associated O-acetyl transferase gene -LRB- MBOAT1 -RRB- in a patient with a novel brachydactyly-syndactyly_syndrome .
20035826	0	O-acyl	32,38	ghrelin	24,31	O-acyl	ghrelin	null	100861189	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|END_ENTITY	Metabolic regulation of ghrelin O-acyl transferase -LRB- GOAT -RRB- expression in the mouse hypothalamus , pituitary , and stomach .
21930173	0	O-acyl	88,94	ghrelin	80,87	O-acyl	ghrelin	null	100861189	Chemical	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Genetic studies on the ghrelin , growth_hormone_secretagogue_receptor -LRB- GHSR -RRB- and ghrelin O-acyl transferase -LRB- GOAT -RRB- genes .
22310717	0	O-linked-N-acetylglucosamine	0,28	Eogt1	107,112	O-linked-N-acetylglucosamine	Eogt1	null	285203	Chemical	Gene	modification|amod|START_ENTITY modification|nmod|END_ENTITY	O-linked-N-acetylglucosamine modification of mammalian Notch receptors by an atypical O-GlcNAc transferase Eogt1 .
15342936	3	O2	615,617	CD34	597,601	O2	CD34	null	947	Chemical	Gene	cells|nmod|START_ENTITY cells|compound|END_ENTITY	We report here that 7-day LCs of cord blood CD34 + cells at 3 % O2 maintain SRC better than at 20 % O2 and allow a similar amplification of CFCs -LRB- 35 - to 50-fold -RRB- without modifying the CD34 + cell proliferation .
1213968	0	O2	11,13	CO2	45,48	O2	CO2	null	717	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|response response|nmod|END_ENTITY	Effects of O2 on the ventilatory response to CO2 in preterm infants .
1906698	0	O2	43,45	CO2	13,16	O2	CO2	null	717	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of CO2 and low concentrations of O2 on fermentative metabolism of the ruminal ciliate Polyplastron multivesiculatum .
6768701	0	O2	23,25	CO2	10,13	O2	CO2	null	717	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of CO2 and 100 % O2 on cerebral blood flow in preterm infants .
22865553	0	O2	33,35	NOX2	0,4	O2	NOX2	null	1536	Chemical	Gene	sensor|compound|START_ENTITY sensor|nsubj|END_ENTITY	NOX2 -LRB- gp91phox -RRB- is a predominant O2 sensor in a human airway chemoreceptor cell line : biochemical , molecular , and electrophysiological evidence .
12888880	0	O2	104,106	TNF_alpha	82,91	O2	TNF alpha	null	7124	Chemical	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	Enhanced TNF_alpha and oxidative stress in patients with heart_failure : effect of TNF_alpha on platelet O2 - production .
11254668	0	O2	83,85	adenosine_deaminase	21,40	O2	adenosine deaminase	null	41092(Tax:7227)	Chemical	Gene	deprivation|compound|START_ENTITY END_ENTITY|nmod|deprivation	Mutation in pre-mRNA adenosine_deaminase markedly attenuates neuronal tolerance to O2 deprivation in Drosophila_melanogaster .
2854415	0	O2	39,41	cytochrome_c	23,35	O2	cytochrome c	null	54205	Chemical	Gene	transfer|nmod|START_ENTITY transfer|nmod|END_ENTITY	Electron transfer from cytochrome_c to O2 .
19164527	0	O2	48,50	cytochrome_c_oxidase	84,104	O2	cytochrome c oxidase	null	282199(Tax:9913)	Chemical	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	A peroxide bridge between Fe and Cu ions in the O2 reduction site of fully oxidized cytochrome_c_oxidase could suppress the proton pump .
8621799	0	O2	36,38	erythropoietin	11,25	O2	erythropoietin	null	2056	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of erythropoietin on muscle O2 transport during exercise in patients with chronic_renal_failure .
16751246	0	O2	35,37	myoglobin	61,70	O2	myoglobin	null	4151	Chemical	Gene	pathways|nmod|START_ENTITY pathways|nmod|END_ENTITY	Imaging the migration pathways for O2 , CO , NO , and Xe inside myoglobin .
10579226	0	O2	135,137	neurokinin-1_receptor	94,115	O2	neurokinin-1 receptor	null	100135626(Tax:10141)	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Distribution of Fos-like immunoreactivity in guinea-pig brain following administration of the neurokinin-1_receptor agonist , -LSB- SAR9 , MET -LRB- O2 -RRB- 11 -RSB- substance P .
14993144	0	O2	92,94	p47phox	18,25	O2	p47phox	null	17969(Tax:10090)	Chemical	Gene	roles|nmod|START_ENTITY roles|nmod|END_ENTITY	Opposing roles of p47phox in basal versus angiotensin_II-stimulated alterations in vascular O2 - production , vascular tone , and mitogen-activated protein kinase activation .
9530169	0	O2	0,2	surfactant_protein_A	13,33	O2	surfactant protein A	null	653509	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|amod|END_ENTITY	O2 regulates surfactant_protein_A mRNA transcription and stability in human fetal lung in vitro .
2242301	0	O6-benzylguanine	72,88	O6-alkylguanine-DNA_alkyltransferase	24,60	O6-benzylguanine	O6-alkylguanine-DNA alkyltransferase	MESH:C064976	17314(Tax:10090)	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|END_ENTITY	Modulation of mammalian O6-alkylguanine-DNA_alkyltransferase in vivo by O6-benzylguanine and its effect on the sensitivity of a human glioma_tumor to 1 - -LRB- 2-chloroethyl -RRB- -3 - -LRB- 4-methylcyclohexyl -RRB- -1 - nitrosourea .
7805187	0	O6-benzylguanine	99,115	O6-alkylguanine-DNA_alkyltransferase	14,50	O6-benzylguanine	O6-alkylguanine-DNA alkyltransferase	MESH:C064976	25332(Tax:10116)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of O6-alkylguanine-DNA_alkyltransferase in animal and human ovarian_tumor cell lines by O6-benzylguanine and sensitization to BCNU .
7923129	0	O6-benzylguanine	14,30	O6-alkylguanine-DNA_alkyltransferase	50,86	O6-benzylguanine	O6-alkylguanine-DNA alkyltransferase	MESH:C064976	17314(Tax:10090)	Chemical	Gene	Metabolism|nmod|START_ENTITY Metabolism|nmod|END_ENTITY	Metabolism of O6-benzylguanine , an inactivator of O6-alkylguanine-DNA_alkyltransferase .
8624262	0	O6-benzylguanine	0,16	O6-alkylguanine-DNA_alkyltransferase	73,109	O6-benzylguanine	O6-alkylguanine-DNA alkyltransferase	MESH:C064976	17314(Tax:10090)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|activity activity|compound|END_ENTITY	O6-benzylguanine enhances the sensitivity of a glioma xenograft with low O6-alkylguanine-DNA_alkyltransferase activity to temozolomide and BCNU .
10933201	0	O6-benzylguanine	51,67	O6-methylguanine_DNA_methyltransferase	124,162	O6-benzylguanine	O6-methylguanine DNA methyltransferase	MESH:C064976	4255	Chemical	Gene	Protection|nmod|START_ENTITY Protection|nmod|END_ENTITY	Protection of hematopoietic cells against combined O6-benzylguanine and chloroethylnitrosourea treatment by mutant forms of O6-methylguanine_DNA_methyltransferase .
11059778	0	O6-methylguanine	32,48	Bcl-2	52,57	O6-methylguanine	Bcl-2	MESH:C008449	596	Chemical	Gene	induced|nmod|START_ENTITY Apoptosis|acl|induced END_ENTITY|nsubj|Apoptosis	Apoptosis induced by DNA damage O6-methylguanine is Bcl-2 and caspase-9 / 3 regulated and Fas/caspase -8 independent .
7885384	0	O6-methylguanine	29,45	MGMT	24,28	O6-methylguanine	MGMT	MESH:C008449	4255	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Expression of the human MGMT O6-methylguanine DNA methyltransferase gene in a yeast alkylation-sensitive mutant : its effects on both exogenous and endogenous DNA alkylation damage .
7519972	0	O6-methylguanine	82,98	O6-alkylguanine-DNA_alkyltransferase	133,169	O6-methylguanine	O6-alkylguanine-DNA alkyltransferase	MESH:C008449	25332(Tax:10116)	Chemical	Gene	accumulation|nmod|START_ENTITY effects|nmod|accumulation effects|nmod|END_ENTITY	Differential effects of procarbazine and methylnitrosourea on the accumulation of O6-methylguanine and the depletion and recovery of O6-alkylguanine-DNA_alkyltransferase in rat tissues .
9153417	0	O6-methylguanine	24,40	O6-methylguanine-DNA_methyltransferase	80,118	O6-methylguanine	O6-methylguanine-DNA methyltransferase	MESH:C008449	4255	Chemical	Gene	recognition|nmod|START_ENTITY recognition|nmod|END_ENTITY	Specific recognition of O6-methylguanine in DNA by active site mutants of human O6-methylguanine-DNA_methyltransferase .
19789303	0	O6_benzyl_guanine	31,48	MGMT	12,16	O6 benzyl guanine	MGMT	MESH:C064976	4255	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Blockade of MGMT expression by O6_benzyl_guanine leads to inhibition of pancreatic_cancer growth and induction of apoptosis .
19118104	0	OAG	0,3	PI3K	32,36	OAG	PI3K	null	5293	Chemical	Gene	induces|nsubj|START_ENTITY induces|dep|END_ENTITY	OAG induces an additional PKC - , PI3K - , and Rac2-mediated signaling pathway up-regulating NOX2 activity , independently of Ca2 + entry .
2200498	0	OC125	104,109	CA125	38,43	OC125	CA125	null	94025	Chemical	Gene	identification|nmod|START_ENTITY identification|nmod|END_ENTITY	Immunohistochemical identification of CA125 and the F -LRB- ab ' -RRB- 2 fragments of the murine monoclonal antibody OC125 in ovarian_cancer tissue .
11990779	0	OC144-093	0,9	P_glycoprotein	19,33	OC144-093	P glycoprotein	MESH:C410029	5243	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	OC144-093 , a novel P_glycoprotein inhibitor for the enhancement of anti-epileptic therapy .
15491992	4	ODC	531,534	AzI	536,539	ODC	AzI	null	4946	Chemical	Gene	protein|nmod|START_ENTITY protein|nsubj|END_ENTITY	We show here that like ODC , AzI is also a short-lived protein that undergoes proteasomal degradation .
18564062	0	OH	62,64	Fyn	8,11	OH	Fyn	MESH:C031356	2534	Chemical	Gene	Role|dep|START_ENTITY Role|nmod|END_ENTITY	Role of Fyn and PI3K in H2O2-induced inhibition of apical Cl - / OH - exchange activity in human intestinal epithelial cells .
15637072	0	OH	75,77	c-Src	15,20	OH	c-Src	MESH:C031356	6714	Chemical	Gene	Involvement|dep|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of c-Src and protein_kinase_C_delta in the inhibition of Cl -LRB- - -RRB- / OH - exchange activity in Caco-2 cells by serotonin .
25710388	0	OH-Initiated	45,57	HO2	30,33	OH-Initiated	HO2	null	3163	Chemical	Gene	Oxidation|amod|START_ENTITY END_ENTITY|nmod|Oxidation	Formation of Furan along with HO2 during the OH-Initiated Oxidation of 2,5-DHF and 2,3-DHF : An Experimental and Computational Study .
7575620	0	OK-1035	0,7	DNA-dependent_protein_kinase	34,62	OK-1035	DNA-dependent protein kinase	MESH:C095985	5591	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	OK-1035 , a selective inhibitor of DNA-dependent_protein_kinase .
8619835	0	OK-1035	40,47	DNA-dependent_protein_kinase	0,28	OK-1035	DNA-dependent protein kinase	MESH:C095985	5591	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	DNA-dependent_protein_kinase inhibitor -LRB- OK-1035 -RRB- suppresses p21 expression in HCT116 cells containing wild-type p53 induced by adriamycin .
21388428	0	OK-432	92,98	IL-6	57,61	OK-432	IL-6	MESH:D010844	3569	Chemical	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	MAPKs ERK and p38 , but not JNK phosphorylation , modulate IL-6 and TNF-a secretion following OK-432 in vitro stimulation of purified human monocytes .
6177428	0	OK-432	55,61	interferon-gamma	13,29	OK-432	interferon-gamma	MESH:D010844	15978(Tax:10090)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of interferon-gamma in mouse spleen cells by OK-432 , a preparation of Streptococcus_pyogenes .
3874175	0	OK-432	62,68	interleukin_1	16,29	OK-432	interleukin 1	MESH:D010844	111343(Tax:10090)	Chemical	Gene	Augmentation|nmod|START_ENTITY Augmentation|nmod|production production|amod|END_ENTITY	Augmentation of interleukin_1 and interleukin_2 production by OK-432 .
8903482	0	OK432	18,23	manganese_superoxide_dismutase	32,62	OK432	manganese superoxide dismutase	MESH:D010844	6648	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Anti-cancer agent OK432 induces manganese_superoxide_dismutase in human granulocytes .
26269774	0	OKN-007	0,7	VEGFR-2	18,25	OKN-007	VEGFR-2	MESH:C552724	16542(Tax:10090)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|levels levels|compound|END_ENTITY	OKN-007 decreases VEGFR-2 levels in a preclinical GL261 mouse glioma model .
9637355	0	OM-89	30,35	HSP60	64,69	OM-89	HSP60	MESH:C050501	63868(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Antirheumatic E. _ coli extract OM-89 induces T cell responses to HSP60 and 70 .
15766665	0	ON01910	0,7	Plk1	59,63	ON01910	Plk1	MESH:C507134	5347	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	ON01910 , a non-ATP-competitive small molecule inhibitor of Plk1 , is a potent anticancer agent .
15127571	0	ONO-1078	22,30	endothelin-1	105,117	ONO-1078	endothelin-1	MESH:C047681	24323(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY induced|nsubj|effect induced|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Protective effect of ONO-1078 , a leukotriene receptor antagonist , on focal cerebral_ischemia induced by endothelin-1 in rats -RSB- .
15618882	0	ONO-1714	63,71	GDNF	14,18	ONO-1714	GDNF	MESH:C407360	25453(Tax:10116)	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of GDNF in spinal_cord_injury and its repression by ONO-1714 .
14654171	0	ONO-1714	35,43	iNOS	19,23	ONO-1714	iNOS	MESH:C407360	24599(Tax:10116)	Chemical	Gene	Effect|appos|START_ENTITY Effect|nmod|inhibitor inhibitor|compound|END_ENTITY	Effect of a potent iNOS inhibitor -LRB- ONO-1714 -RRB- on acetaminophen-induced hepatotoxicity in the rat .
15836854	0	ONO-1714	106,114	iNOS	90,94	ONO-1714	iNOS	MESH:C407360	396821(Tax:9823)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Remnant liver_injury after hepatectomy with the pringle maneuver and its inhibition by an iNOS inhibitor -LRB- ONO-1714 -RRB- in a pig model .
18567618	0	ONO-1714	179,187	iNOS	192,196	ONO-1714	iNOS	MESH:C407360	4843	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Increased expression of inducible_nitric_oxide_synthase -LRB- iNOS -RRB- in N-nitrosobis -LRB- 2-oxopropyl -RRB- amine-induced hamster pancreatic_carcinogenesis and prevention of cancer development by ONO-1714 , an iNOS inhibitor .
18567618	0	ONO-1714	179,187	iNOS	57,61	ONO-1714	iNOS	MESH:C407360	4843	Chemical	Gene	amine-induced|nmod|START_ENTITY amine-induced|nsubj|expression expression|nmod|END_ENTITY	Increased expression of inducible_nitric_oxide_synthase -LRB- iNOS -RRB- in N-nitrosobis -LRB- 2-oxopropyl -RRB- amine-induced hamster pancreatic_carcinogenesis and prevention of cancer development by ONO-1714 , an iNOS inhibitor .
16982182	0	ONO-1714	61,69	inducible_nitric_oxide_synthase	28,59	ONO-1714	inducible nitric oxide synthase	MESH:C407360	18126(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|nmod|END_ENTITY	A novel potent inhibitor of inducible_nitric_oxide_synthase , ONO-1714 , reduces hyperoxic lung_injury in mice .
17417780	0	ONO-1714	54,62	inducible_nitric_oxide_synthase	11,42	ONO-1714	inducible nitric oxide synthase	MESH:C407360	18126(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	A specific inducible_nitric_oxide_synthase inhibitor , ONO-1714 attenuates inflammation-related large bowel carcinogenesis in male Apc -LRB- Min / + -RRB- mice .
17721804	0	ONO-1714	54,62	inducible_nitric_oxide_synthase	21,52	ONO-1714	inducible nitric oxide synthase	MESH:C407360	24599(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|nmod|END_ENTITY	A novel inhibitor of inducible_nitric_oxide_synthase , ONO-1714 , does not ameliorate hypoxia-induced pulmonary_hypertension in rats .
18567618	0	ONO-1714	179,187	inducible_nitric_oxide_synthase	24,55	ONO-1714	inducible nitric oxide synthase	MESH:C407360	4843	Chemical	Gene	amine-induced|nmod|START_ENTITY amine-induced|nsubj|expression expression|nmod|iNOS iNOS|amod|END_ENTITY	Increased expression of inducible_nitric_oxide_synthase -LRB- iNOS -RRB- in N-nitrosobis -LRB- 2-oxopropyl -RRB- amine-induced hamster pancreatic_carcinogenesis and prevention of cancer development by ONO-1714 , an iNOS inhibitor .
19696162	0	ONO-1714	74,82	inducible_nitric_oxide_synthase	31,62	ONO-1714	inducible nitric oxide synthase	MESH:C407360	101823656	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Chemopreventative effect of an inducible_nitric_oxide_synthase inhibitor , ONO-1714 , on inflammation-associated biliary_carcinogenesis in hamsters .
15245789	0	ONO-1714	53,61	neuronal_NOS	71,83	ONO-1714	neuronal NOS	MESH:C407360	24598(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	The potent inducible_nitric_oxide_synthase inhibitor ONO-1714 inhibits neuronal_NOS and exerts antinociception in rats .
15519361	0	ONO-1924H	27,36	PARP	82,86	ONO-1924H	PARP	MESH:C493991	25591(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Neuroprotective effects of ONO-1924H , an inhibitor of poly_ADP-ribose_polymerase -LRB- PARP -RRB- , on cytotoxicity of PC12 cells and ischemic cerebral_damage .
15519361	0	ONO-1924H	27,36	poly_ADP-ribose_polymerase	54,80	ONO-1924H	poly ADP-ribose polymerase	MESH:C493991	25591(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Neuroprotective effects of ONO-1924H , an inhibitor of poly_ADP-ribose_polymerase -LRB- PARP -RRB- , on cytotoxicity of PC12 cells and ischemic cerebral_damage .
1907900	0	ONO-2235	139,147	aldose_reductase	111,127	ONO-2235	aldose reductase	MESH:C038131	100751272	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Polyol pathway in tissues of spontaneously diabetic Chinese_hamsters -LRB- Cricetulus_griseus -RRB- and the effect of an aldose_reductase inhibitor , ONO-2235 .
15193540	0	ONO-4819	51,59	EP4	27,30	ONO-4819	EP4	MESH:C487764	84023(Tax:10116)	Chemical	Gene	agonist|dobj|START_ENTITY agonist|nsubj|receptor receptor|appos|END_ENTITY	Prostaglandin_E2 receptor -LRB- EP4 -RRB- selective agonist -LRB- ONO-4819 .
15196475	0	ONO-4819	53,61	EP4	89,92	ONO-4819	EP4	MESH:C487764	5734	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Up-regulation of lymphocytic cholinergic activity by ONO-4819 , a selective prostaglandin EP4 receptor agonist , in MOLT-3 human leukemic_T cells .
17681894	0	ONO-4819	30,38	EP4	17,20	ONO-4819	EP4	MESH:C487764	19219(Tax:10090)	Chemical	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	Prostaglandin E2 EP4 agonist -LRB- ONO-4819 -RRB- accelerates BMP-induced osteoblastic differentiation .
21187596	0	ONO-5334	65,73	cathepsin_K	42,53	ONO-5334	cathepsin K	MESH:C560865	102120416	Chemical	Gene	-RSB-|compound|START_ENTITY inhibitor|appos|-RSB- inhibitor|compound|END_ENTITY	-LSB- New approach for osteoporosis treatment : cathepsin_K inhibitor , ONO-5334 -RSB- .
21719717	0	ONO-5334	115,123	cathepsin_K	92,103	ONO-5334	cathepsin K	MESH:C560865	1513	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Pharmacodynamic effects on biochemical markers of bone turnover and pharmacokinetics of the cathepsin_K inhibitor , ONO-5334 , in an ascending multiple-dose , phase 1 study .
21982869	0	ONO-5334	11,19	cathepsin_K	56,67	ONO-5334	cathepsin K	MESH:C560865	1513	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|inhibitor inhibitor|nmod|END_ENTITY	Effects of ONO-5334 , a novel orally-active inhibitor of cathepsin_K , on bone metabolism .
24038152	0	ONO-5334	40,48	cathepsin_K	18,29	ONO-5334	cathepsin K	MESH:C560865	1513	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|effect effect|nmod|END_ENTITY	The effect of the cathepsin_K inhibitor ONO-5334 on trabecular and cortical bone in postmenopausal_osteoporosis : the OCEAN study .
24115072	0	ONO-5334	85,93	cathepsin_K	95,106	ONO-5334	cathepsin K	MESH:C560865	1513	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Population pharmacokinetic and pharmacodynamic modeling of different formulations of ONO-5334 , cathepsin_K inhibitor , in Caucasian and Japanese postmenopausal females .
24317478	0	ONO-5334	0,8	cathepsin_K	12,23	ONO-5334	cathepsin K	MESH:C560865	29175(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	ONO-5334 , a cathepsin_K inhibitor , improves bone strength by preferentially increasing cortical bone mass in ovariectomized rats .
24458199	0	ONO-5334	112,120	cathepsin_K	89,100	ONO-5334	cathepsin K	MESH:C560865	1513	Chemical	Gene	markers|amod|START_ENTITY markers|nmod|formulation formulation|nmod|END_ENTITY	Bone turnover markers and pharmacokinetics of a new sustained-release formulation of the cathepsin_K inhibitor , ONO-5334 , in healthy post-menopausal women .
24615681	0	ONO-5334	81,89	cathepsin_K	97,108	ONO-5334	cathepsin K	MESH:C560865	1513	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Modeling and simulation of bone_mineral_density response from a phase 2 study of ONO-5334 , a new cathepsin_K inhibitor , to support dose selection in osteoporosis .
24784023	0	ONO-5334	38,46	cathepsin_K	50,61	ONO-5334	cathepsin K	MESH:C560865	102120416	Chemical	Gene	treatment|nmod|START_ENTITY Effects|nmod|treatment Effects|appos|inhibitor inhibitor|compound|END_ENTITY	Effects of eight-month treatment with ONO-5334 , a cathepsin_K inhibitor , on bone metabolism , strength and microstructure in ovariectomized cynomolgus_monkeys .
26921823	0	ONO-5334	61,69	cathepsin_K	39,50	ONO-5334	cathepsin K	MESH:C560865	102120416	Chemical	Gene	Effects|amod|START_ENTITY Effects|nmod|treatment treatment|nmod|inhibitor inhibitor|compound|END_ENTITY	Effects of 16-month treatment with the cathepsin_K inhibitor ONO-5334 on bone markers , mineral density , strength and histomorphometry in ovariectomized cynomolgus_monkeys .
23579947	0	ONO-7643	34,42	ghrelin	10,17	ONO-7643	ghrelin	null	58991(Tax:10090)	Chemical	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of ghrelin and anamorelin -LRB- ONO-7643 -RRB- , a selective ghrelin_receptor agonist , on tumor growth in a lung_cancer mouse xenograft model .
26880410	0	ONO-8055	64,72	EP2_and_EP3_receptor	29,49	ONO-8055	EP2 and EP3 receptor	null	81752(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Promising effects of a novel EP2_and_EP3_receptor dual agonist , ONO-8055 , on neurogenic underactive bladder in a rat lumbar canal stenosis model .
21396778	0	ONO-8130	0,8	prostanoid_EP1_receptor	22,45	ONO-8130	prostanoid EP1 receptor	null	19216(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	ONO-8130 , a selective prostanoid_EP1_receptor antagonist , relieves bladder_pain in mice with cyclophosphamide-induced cystitis .
11574375	0	ONO-8711	61,69	EP1	36,39	ONO-8711	EP1	MESH:C122148	25637(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	A prostaglandin_E2 receptor subtype EP1 receptor antagonist -LRB- ONO-8711 -RRB- reduces_hyperalgesia , allodynia , and c-fos gene expression in rats with chronic_nerve_constriction .
8922777	0	ONO-9902	27,35	enkephalinase	40,53	ONO-9902	enkephalinase	MESH:C104138	24590(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Antinociceptive effects of ONO-9902 , an enkephalinase inhibitor , after visceral stress_condition in rats .
16143052	0	ONO-AE-248	74,84	EP3	61,64	ONO-AE-248	EP3	MESH:C121546	5733	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Non-apoptotic , non-necrotic death of neutrophils induced by EP3 agonist -- ONO-AE-248 -RSB- .
20023007	0	ONO_3403	0,8	tumor_necrosis_factor	85,106	ONO 3403	tumor necrosis factor	MESH:C100807	21926(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	ONO_3403 , a synthetic serine protease inhibitor , inhibits lipopolysaccharide-induced tumor_necrosis_factor - -LCB- alpha -RCB- and nitric_oxide production and protects mice from lethal endotoxic_shock .
7508645	0	ONO_3708	52,60	thromboxane_A2_receptor	16,39	ONO 3708	thromboxane A2 receptor	MESH:C049855	485056(Tax:9615)	Chemical	Gene	effect|appos|START_ENTITY effect|nmod|antagonist antagonist|amod|END_ENTITY	The effect of a thromboxane_A2_receptor antagonist -LRB- ONO_3708 -RRB- on ischemia-reperfusion injury of the dog pancreas .
7940195	0	ONO_3708	60,68	thromboxane_A2_receptor	25,48	ONO 3708	thromboxane A2 receptor	MESH:C049855	485056(Tax:9615)	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|antagonist antagonist|amod|END_ENTITY	Protective effect of the thromboxane_A2_receptor antagonist ONO_3708 on ischemia-reperfusion injury in the dog liver .
16012790	0	ONT-093	65,72	P-glycoprotein	39,53	ONT-093	P-glycoprotein	MESH:C410029	5243	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	A phase I pharmacokinetic study of the P-glycoprotein inhibitor , ONT-093 , in combination with paclitaxel in patients with advanced_cancer .
25715763	0	OPB-31121	17,26	STAT3	36,41	OPB-31121	STAT3	null	6774	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|compound|END_ENTITY	Phase I study of OPB-31121 , an Oral STAT3 Inhibitor , in Patients with Advanced_Solid_Tumors .
25912076	0	OPB-51602	17,26	signal_transducer_and_activator_of_transcription_3	49,99	OPB-51602	signal transducer and activator of transcription 3	null	6774	Chemical	Gene	study|nmod|START_ENTITY study|appos|inhibitor inhibitor|nmod|END_ENTITY	Phase I study of OPB-51602 , an oral inhibitor of signal_transducer_and_activator_of_transcription_3 , in patients with relapsed/refractory hematological_malignancies .
15985260	0	OPC-14523	49,58	5-HT1A	76,82	OPC-14523	5-HT1A	MESH:C404207	3350	Chemical	Gene	START_ENTITY|nmod|receptors receptors|compound|END_ENTITY	In vitro profile of the antidepressant candidate OPC-14523 at rat and human 5-HT1A receptors .
3171977	0	OR-462	63,69	catechol-O-methyltransferase	20,48	OR-462	catechol-O-methyltransferase	MESH:C057364	24267(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|inhibition inhibition|amod|END_ENTITY	Favorable effect of catechol-O-methyltransferase inhibition by OR-462 in experimental models of Parkinson 's _ disease .
21673091	0	OSI-027	32,39	mTORC1	77,83	OSI-027	mTORC1	MESH:C568605	382056(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Preclinical characterization of OSI-027 , a potent and selective inhibitor of mTORC1 and mTORC2 : distinct from rapamycin .
26284306	0	OSI-027	38,45	mTORC1	83,89	OSI-027	mTORC1	MESH:C568605	382056(Tax:10090)	Chemical	Gene	Activity|nmod|START_ENTITY Activity|nmod|END_ENTITY	The Antipancreatic_Cancer Activity of OSI-027 , a Potent and Selective Inhibitor of mTORC1 and mTORC2 .
12908562	0	OSI-774	71,78	epidermal_growth_factor_receptor	19,51	OSI-774	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|Development Development|nmod|END_ENTITY	Development of the epidermal_growth_factor_receptor inhibitor Tarceva -LRB- OSI-774 -RRB- .
15035290	0	OSI-774	131,138	epidermal_growth_factor_receptor	143,175	OSI-774	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Inverse correlation of epidermal_growth_factor_receptor messenger RNA induction and suppression of anchorage-independent growth by OSI-774 , an epidermal_growth_factor_receptor tyrosine kinase inhibitor , in glioblastoma_multiforme cell lines .
15035290	0	OSI-774	131,138	epidermal_growth_factor_receptor	23,55	OSI-774	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	RNA|nmod|START_ENTITY RNA|nsubj|correlation correlation|nmod|messenger messenger|compound|END_ENTITY	Inverse correlation of epidermal_growth_factor_receptor messenger RNA induction and suppression of anchorage-independent growth by OSI-774 , an epidermal_growth_factor_receptor tyrosine kinase inhibitor , in glioblastoma_multiforme cell lines .
15638953	0	OSI-774	108,115	epidermal_growth_factor_receptor	38,70	OSI-774	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	erlotinib|appos|START_ENTITY tyrosine|dobj|erlotinib tyrosine|nsubj|data data|nmod|END_ENTITY	Phase II clinical trial data with the epidermal_growth_factor_receptor tyrosine kinase inhibitor erlotinib -LRB- OSI-774 -RRB- in non-small-cell_lung_cancer .
21425998	0	OSI-906	13,20	IGF-1_receptor	79,93	OSI-906	IGF-1 receptor	MESH:C551528	3480	Chemical	Gene	Discovery|nmod|START_ENTITY Discovery|dep|inhibitor inhibitor|nmod|END_ENTITY	Discovery of OSI-906 : a selective and orally efficacious dual inhibitor of the IGF-1_receptor and insulin_receptor .
21920748	0	OSI-930	62,69	c-Kit	14,19	OSI-930	c-Kit	MESH:C505207	3815	Chemical	Gene	analogues|nmod|START_ENTITY Inhibition|nmod|analogues Inhibition|nmod|END_ENTITY	Inhibition of c-Kit , VEGFR-2 -LRB- KDR -RRB- , and ABCG2 by analogues of OSI-930 .
25017515	0	OSU	40,43	Aurora_kinase_A	0,15	OSU	Aurora kinase A	null	6790	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Aurora_kinase_A is a possible target of OSU -03012 to destabilize MYC family proteins .
17848913	0	OSU-03012	80,89	PDK-1	0,5	OSU-03012	PDK-1	MESH:C500894	5163	Chemical	Gene	compound|compound|START_ENTITY using|dobj|compound pathway|advcl|using END_ENTITY|appos|pathway	PDK-1 / AKT pathway as a novel therapeutic target in rhabdomyosarcoma cells using OSU-03012 compound .
19359162	0	OSU-03012	48,57	PDK-1	67,72	OSU-03012	PDK-1	MESH:C500894	228026(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Growth inhibitory and anti-tumour activities of OSU-03012 , a novel PDK-1 inhibitor , on vestibular_schwannoma and malignant_schwannoma cells .
18798257	0	OSU03012	0,8	Erk1/2	19,25	OSU03012	Erk1/2	MESH:C500894	5595;5594	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	OSU03012 activates Erk1/2 and Cdks leading to the accumulation of cells in the S-phase and apoptosis .
25042151	0	OTX008	0,6	galectin-1	48,58	OTX008	galectin-1	null	3956	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	OTX008 , a selective small-molecule inhibitor of galectin-1 , downregulates cancer cell proliferation , invasion and tumour angiogenesis .
25989842	0	OTX015	14,20	BRD2	29,33	OTX015	BRD2	null	6046	Chemical	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	BET inhibitor OTX015 targets BRD2 and BRD4 and decreases c-MYC in acute leukemia cells .
26445848	0	OXA-11	40,46	FAK	26,29	OXA-11	FAK	null	14083(Tax:10090)	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|action action|nmod|END_ENTITY	Anti-metastatic action of FAK inhibitor OXA-11 in combination with VEGFR-2 signaling blockade in pancreatic_neuroendocrine_tumors .
19153210	0	Obestatin	0,9	Akt	21,24	Obestatin	Akt	MESH:D054439	207	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Obestatin stimulates Akt signalling in gastric_cancer cells through beta-arrestin-mediated epidermal_growth_factor_receptor transactivation .
26811456	0	Obeticholic_acid	0,16	farnesoid_X_receptor	55,75	Obeticholic acid	farnesoid X receptor	MESH:C464660	20186(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonist agonist|nmod|END_ENTITY	Obeticholic_acid , a synthetic bile_acid agonist of the farnesoid_X_receptor , attenuates experimental_autoimmune_encephalomyelitis .
1699251	0	Octreotide	0,10	VIP	79,82	Octreotide	VIP	MESH:D015282	117064(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Octreotide inhibits increases in short-circuit current induced in rat colon by VIP , substance P , serotonin and aminophylline .
15080778	0	Octreotide	0,10	growth_hormone	94,108	Octreotide	growth hormone	MESH:D015282	2688	Chemical	Gene	repeatable|amod|START_ENTITY effective|nsubj|repeatable effective|advcl|controlling controlling|dobj|secretion secretion|amod|END_ENTITY	Octreotide long-acting repeatable and lanreotide Autogel are equally effective in controlling growth_hormone secretion in acromegalic patients .
2493033	0	Octreotide	0,10	growth_hormone	27,41	Octreotide	growth hormone	MESH:D015282	2688	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	Octreotide suppresses both growth_hormone -LRB- GH -RRB- and GH-releasing_hormone -LRB- GHRH -RRB- in acromegaly due to ectopic GHRH secretion .
8187302	0	Octreotide	0,10	growth_hormone	91,105	Octreotide	growth hormone	MESH:D015282	2688	Chemical	Gene	administration|amod|START_ENTITY enhances|nsubj|administration enhances|dobj|responses responses|nmod|END_ENTITY	Octreotide administration , under particular temporal conditions , enhances the responses of growth_hormone to growth_hormone-releasing_hormone in normal subjects .
8507446	0	Octreotide	0,10	insulin	43,50	Octreotide	insulin	MESH:D015282	3630	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|secretion secretion|compound|END_ENTITY	Octreotide , a somatostatin analog , reduces insulin secretion and increases renal Na + excretion in lean essential hypertensive patients .
10929949	0	Octreotide	0,10	myeloperoxidase	20,35	Octreotide	myeloperoxidase	MESH:D015282	303413(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Octreotide inhibits myeloperoxidase activity in rat uterus .
11020872	0	Octreotide	0,10	myeloperoxidase	79,94	Octreotide	myeloperoxidase	MESH:D015282	303413(Tax:10116)	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|advcl|suppressing suppressing|dobj|activity activity|compound|END_ENTITY	Octreotide prevents postoperative_adhesion formation by suppressing peritoneal myeloperoxidase activity .
15135923	0	Octreotide	0,10	somatostatin	14,26	Octreotide	somatostatin	MESH:D015282	24797(Tax:10116)	Chemical	Gene	START_ENTITY|appos|analogue analogue|compound|END_ENTITY	Octreotide , a somatostatin analogue , attenuates movement evoked discharges of fine afferent units from inflamed knee joints of rats .
3068036	0	Octreotide	0,10	somatostatin	34,46	Octreotide	somatostatin	MESH:D015282	6750	Chemical	Gene	START_ENTITY|dep|analog analog|nmod|END_ENTITY	Octreotide : a synthetic analog of somatostatin .
26531719	0	Octreotide	0,10	somatostatin_receptors_2_and_5	98,128	Octreotide	somatostatin receptors 2 and 5	MESH:D015282	6752	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|up-regulation up-regulation|nmod|END_ENTITY	Octreotide in combination with AT-101 induces cytotoxicity and apoptosis through up-regulation of somatostatin_receptors_2_and_5 in DU-145 prostate_cancer cells .
18286425	0	Octyl-methoxycinnamate	0,22	LHRH	65,69	Octyl-methoxycinnamate	LHRH	MESH:C118580	25194(Tax:10116)	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|release release|compound|END_ENTITY	Octyl-methoxycinnamate -LRB- OMC -RRB- , an ultraviolet -LRB- UV -RRB- filter , alters LHRH and amino_acid neurotransmitters release from hypothalamus of immature rats .
18417718	0	Octylphenol	0,11	resistin	23,31	Octylphenol	resistin	MESH:C474055	56729	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	Octylphenol stimulates resistin gene expression in 3T3-L1 adipocytes via the estrogen receptor and extracellular signal-regulated kinase pathways .
23013236	0	Odanacatib	0,10	cathepsin_K	24,35	Odanacatib	cathepsin K	MESH:C527128	1513	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Odanacatib , a selective cathepsin_K inhibitor to treat osteoporosis : safety , tolerability , pharmacokinetics and pharmacodynamics -- results from single oral dose studies in healthy volunteers .
24276460	0	Odanacatib	0,10	cathepsin_K	24,35	Odanacatib	cathepsin K	MESH:C527128	1513	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Odanacatib , a selective cathepsin_K inhibitor , demonstrates comparable pharmacodynamics and pharmacokinetics in older men and postmenopausal women .
23226309	0	Oenothein_B	0,11	IFNy	91,95	Oenothein B	IFNy	MESH:C080077	3458	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|compound|END_ENTITY	Oenothein_B , a cyclic dimeric ellagitannin isolated from Epilobium angustifolium , enhances IFNy production by lymphocytes .
3577822	0	Oestradiol	0,10	growth_hormone	30,44	Oestradiol	growth hormone	MESH:D004958	81668(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|compound|END_ENTITY	Oestradiol increases baseline growth_hormone levels in the male rat : possible direct action on the pituitary .
8544991	0	Oestradiol	0,10	oxytocin	44,52	Oestradiol	oxytocin	MESH:D004958	5020	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|exocytosis exocytosis|nmod|END_ENTITY	Oestradiol acutely stimulates exocytosis of oxytocin and vasopressin from dendrites and somata of hypothalamic magnocellular neurons .
25599767	0	Oestrogen	27,36	Androgen_Receptor	53,70	Oestrogen	Androgen Receptor	CHEBI:50114	11835(Tax:10090)	Chemical	Gene	Receptor|compound|START_ENTITY Receptor|parataxis|Dependent Dependent|nsubj|END_ENTITY	Hypothalamic Expression Of Oestrogen Receptor - And Androgen_Receptor Is Sex , Age And Region Dependent In Mice .
25323043	0	Oestrogen	0,9	BMP4	32,36	Oestrogen	BMP4	CHEBI:50114	12159(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Oestrogen inhibits BMP4-induced BMP4 expression in cardiomyocytes : a potential mechanism of oestrogen-mediated protection against cardiac_hypertrophy .
23497505	0	Oestrogen	0,9	EGFR	107,111	Oestrogen	EGFR	CHEBI:50114	1956	Chemical	Gene	increases|nsubj|START_ENTITY increases|nmod|END_ENTITY	Oestrogen increases the activity of oestrogen receptor negative breast_cancer stem cells through paracrine EGFR and Notch signalling .
9829551	0	Oestrogen	0,9	ER_beta	25,32	Oestrogen	ER beta	CHEBI:50114	25149(Tax:10116)	Chemical	Gene	beta|compound|START_ENTITY beta|appos|END_ENTITY	Oestrogen receptor beta -LRB- ER_beta -RRB- .
12763213	0	Oestrogen	0,9	ERbeta	25,31	Oestrogen	ERbeta	CHEBI:50114	2100	Chemical	Gene	beta|compound|START_ENTITY beta|appos|END_ENTITY	Oestrogen receptor beta -LRB- ERbeta -RRB- is abundantly expressed in normal colonic mucosa , but declines in colon_adenocarcinoma paralleling the tumour 's dedifferentiation .
18720455	0	Oestrogen	0,9	ESR1	25,29	Oestrogen	ESR1	CHEBI:50114	2099	Chemical	Gene	gene|compound|START_ENTITY amplification|compound|gene amplification|appos|END_ENTITY	Oestrogen receptor gene -LRB- ESR1 -RRB- amplification is frequent in endometrial_carcinoma and its precursor lesions .
21756268	0	Oestrogen	0,9	GPR54	67,72	Oestrogen	GPR54	CHEBI:50114	84634	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Oestrogen induces rhythmic expression of the Kisspeptin-1 receptor GPR54 in hypothalamic gonadotrophin-releasing_hormone-secreting GT1-7 cells .
11596870	0	Oestrogen	0,9	IGFBP-3	70,77	Oestrogen	IGFBP-3	CHEBI:50114	3486	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Oestrogen regulation of insulin-like_growth_factor_binding_protein-3 -LRB- IGFBP-3 -RRB- and expression of IGFBP-3 messenger RNA in the ovine endometrium .
11596870	0	Oestrogen	0,9	IGFBP-3	97,104	Oestrogen	IGFBP-3	CHEBI:50114	3486	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|RNA RNA|compound|END_ENTITY	Oestrogen regulation of insulin-like_growth_factor_binding_protein-3 -LRB- IGFBP-3 -RRB- and expression of IGFBP-3 messenger RNA in the ovine endometrium .
24495253	0	Oestrogen	0,9	Olfactomedin_4	42,56	Oestrogen	Olfactomedin 4	CHEBI:50114	10562	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Oestrogen receptor-mediated expression of Olfactomedin_4 regulates the progression of endometrial_adenocarcinoma .
26999742	0	Oestrogen	64,73	Tissue_Factor_Pathway_Inhibitor	24,55	Oestrogen	Tissue Factor Pathway Inhibitor	CHEBI:50114	7035	Chemical	Gene	Response|compound|START_ENTITY END_ENTITY|nmod|Response	Oestrogens Downregulate Tissue_Factor_Pathway_Inhibitor through Oestrogen Response Elements in the 5 ' - Flanking Region .
25330806	0	Oestrogen	0,9	adipose	30,37	Oestrogen	adipose	CHEBI:50114	230796(Tax:10090)	Chemical	Gene	START_ENTITY|acl|signalling signalling|nmod|cells cells|compound|END_ENTITY	Oestrogen signalling in white adipose progenitor cells inhibits differentiation into brown adipose and smooth muscle cells .
25330806	0	Oestrogen	0,9	adipose	91,98	Oestrogen	adipose	CHEBI:50114	230796(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Oestrogen signalling in white adipose progenitor cells inhibits differentiation into brown adipose and smooth muscle cells .
3588310	0	Oestrogen	0,9	cathepsin_D	20,31	Oestrogen	cathepsin D	CHEBI:50114	1509	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|levels levels|amod|END_ENTITY	Oestrogen regulates cathepsin_D mRNA levels in oestrogen responsive human breast_cancer cells .
17680883	0	Oestrogen	0,9	dopamine_transporters	51,72	Oestrogen	dopamine transporters	CHEBI:50114	6531	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Oestrogen regulates the expression and function of dopamine_transporters in astrocytes of the nigrostriatal system .
15796760	0	Oestrogen	0,9	insulin-like_growth_factor-I_receptor	23,60	Oestrogen	insulin-like growth factor-I receptor	CHEBI:50114	25718(Tax:10116)	Chemical	Gene	requires|nsubj|START_ENTITY requires|dobj|END_ENTITY	Oestrogen requires the insulin-like_growth_factor-I_receptor for stimulation of prolactin synthesis via mitogen-activated protein kinase .
24495300	0	Oestrogen	0,9	interleukin-21	23,37	Oestrogen	interleukin-21	CHEBI:50114	59067	Chemical	Gene	production|compound|START_ENTITY production|amod|END_ENTITY	Oestrogen up-regulates interleukin-21 production by CD4 -LRB- + -RRB- T lymphocytes in patients with systemic_lupus_erythematosus .
10383486	0	Oestrogen	0,9	myeloperoxidase	35,50	Oestrogen	myeloperoxidase	CHEBI:50114	303413(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|activity activity|compound|END_ENTITY	Oestrogen attenuates post-exercise myeloperoxidase activity in skeletal muscle of male rats .
1457348	0	Oestrogen	0,9	progesterone_receptor	64,85	Oestrogen	progesterone receptor	CHEBI:50114	5241	Chemical	Gene	receptor|compound|START_ENTITY isoforms|nsubj|receptor isoforms|xcomp|END_ENTITY	Oestrogen receptor isoforms , their distribution and relation to progesterone_receptor levels in breast_cancer samples .
19302141	0	Oestrogen	0,9	programmed_death_1	96,114	Oestrogen	programmed death 1	CHEBI:50114	18566(Tax:10090)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|production production|nmod|END_ENTITY	Oestrogen modulates experimental_autoimmune_encephalomyelitis and interleukin-17 production via programmed_death_1 .
7205127	0	Oestrogen	0,9	prolactin	71,80	Oestrogen	prolactin	CHEBI:50114	24683(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|nmod|END_ENTITY	Oestrogen receptors in rat mammary tissue and plasma concentrations of prolactin during mammary carcinogenesis induced by oestrogen and ionizing radiation .
1520341	0	Okadaic_acid	0,12	AP-1	36,40	Okadaic acid	AP-1	MESH:D019319	3726	Chemical	Gene	inducer|nsubj|START_ENTITY inducer|nmod|END_ENTITY	Okadaic_acid is a potent inducer of AP-1 , NF-kappa_B , and tumor_necrosis_factor-alpha in human B lymphocytes .
12046689	0	Okadaic_acid	0,12	ARNT	23,27	Okadaic acid	ARNT	MESH:D019319	405	Chemical	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	Okadaic_acid increases ARNT homodimer transactivation potential .
8794894	0	Okadaic_acid	0,12	CYP2A8	54,60	Okadaic acid	CYP2A8	MESH:D019319	101825889	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|expression expression|compound|END_ENTITY	Okadaic_acid potentiates 3-methylcholanthrene-induced CYP2A8 gene expression in primary cultures of Syrian_hamster hepatocytes : possible involvement of activator protein-1 .
12195275	0	Okadaic_acid	1,13	EAAT1	62,67	Okadaic acid	EAAT1	MESH:D019319	29483(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	-LSB- Okadaic_acid induces the expression of glutamate transporter EAAT1 in the neurons of rat brain -RSB- .
8392806	0	Okadaic_acid	0,12	IGF-II_receptor	24,39	Okadaic acid	IGF-II receptor	MESH:D019319	3482	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|translocation translocation|amod|END_ENTITY	Okadaic_acid stimulates IGF-II_receptor translocation and inhibits insulin action in adipocytes .
12921778	0	Okadaic_acid	0,12	IkappaBalpha	85,97	Okadaic acid	IkappaBalpha	MESH:D019319	4792	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|nmod|END_ENTITY	Okadaic_acid induces sustained activation of NFkappaB and degradation of the nuclear IkappaBalpha in human neutrophils .
16132703	0	Okadaic_acid	0,12	IkappaBalpha	49,61	Okadaic acid	IkappaBalpha	MESH:D019319	4792	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Okadaic_acid induces tyrosine phosphorylation of IkappaBalpha that mediated by PKR pathway in human osteoblastic MG63 cells .
12921778	0	Okadaic_acid	0,12	NFkappaB	45,53	Okadaic acid	NFkappaB	MESH:D019319	4790	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|nmod|END_ENTITY	Okadaic_acid induces sustained activation of NFkappaB and degradation of the nuclear IkappaBalpha in human neutrophils .
8080455	0	Okadaic_acid	0,12	activator_protein_1	21,40	Okadaic acid	activator protein 1	MESH:D019319	24516(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|activity activity|amod|END_ENTITY	Okadaic_acid induces activator_protein_1 activity and immediate early gene transcription in rat pheochromocytoma cells .
1733783	0	Okadaic_acid	0,12	angiotensin_II	22,36	Okadaic acid	angiotensin II	MESH:D019319	24179(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|stimulation stimulation|amod|END_ENTITY	Okadaic_acid inhibits angiotensin_II stimulation of Ins -LRB- 1,4,5 -RRB- P3 and calcium signalling in rat hepatocytes .
21718298	0	Okadaic_acid	0,12	matrix_metalloproteinase-9	21,47	Okadaic acid	matrix metalloproteinase-9	MESH:D019319	17395(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Okadaic_acid induces matrix_metalloproteinase-9 expression in fibroblasts : crosstalk between protein phosphatase inhibition and b-adrenoceptor signalling .
7890729	0	Okadaic_acid	0,12	nerve_growth_factor	23,42	Okadaic acid	nerve growth factor	MESH:D019319	310738(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|secretion secretion|compound|END_ENTITY	Okadaic_acid increases nerve_growth_factor secretion , mRNA stability , and gene transcription in primary cultures of cortical astrocytes .
12210726	0	Okadaic_acid	0,12	osteopontin	24,35	Okadaic acid	osteopontin	MESH:D019319	6696	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	Okadaic_acid stimulates osteopontin expression through de novo induction of AP-1 .
26012341	0	Ol	118,120	riz	122,125	Ol	riz	null	7799	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- `` Influence of epidermal friction and wear on papillary patterns '' : unpublished fingerprinting experiments by Federico Ol riz Aguilera -LRB- 1855-1912 -RRB- -RSB- .
22952485	0	Olanzapine	89,99	Insulin	45,52	Olanzapine	Insulin	MESH:C076029	3630	Chemical	Gene	Initiated|nmod|START_ENTITY Resistance|nmod|Initiated Resistance|compound|END_ENTITY	Effect of Early Intervention with Omega-3 on Insulin Resistance in Patients Initiated on Olanzapine with either Sodium_Valproate or Lithium : A randomized , Double-blind , Placebo-Controlled Trial .
21545827	0	Olanzapine	0,10	Nt-3	47,51	Olanzapine	Nt-3	MESH:C076029	81737(Tax:10116)	Chemical	Gene	increases|compound|START_ENTITY END_ENTITY|nsubj|increases	Olanzapine plus fluoxetine treatment increases Nt-3 protein levels in the rat prefrontal cortex .
16702887	0	Olanzapine	0,10	adiponectin	70,81	Olanzapine	adiponectin	MESH:C076029	9370	Chemical	Gene	treatment|amod|START_ENTITY associated|nsubjpass|treatment associated|nmod|END_ENTITY	Olanzapine treatment is associated with reduced high molecular weight adiponectin in serum : a potential mechanism for olanzapine-induced insulin resistance in patients with schizophrenia .
18295757	0	Olanzapine	0,10	glycogen_synthase_kinase-3beta	20,50	Olanzapine	glycogen synthase kinase-3beta	MESH:C076029	56637(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Olanzapine inhibits glycogen_synthase_kinase-3beta : an investigation by docking simulation and experimental validation .
14728104	0	Olanzapine	0,10	insulin	19,26	Olanzapine	insulin	MESH:C076029	3630	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|resistance resistance|compound|END_ENTITY	Olanzapine induces insulin resistance : results from a prospective study .
23926289	0	Olanzapine	0,10	mammalian_target_of_rapamycin	29,58	Olanzapine	mammalian target of rapamycin	MESH:C076029	2475	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Olanzapine activates hepatic mammalian_target_of_rapamycin : new mechanistic insight into metabolic dysregulation with atypical antipsychotic drugs .
19131173	0	Olanzapine	0,10	prolactin	81,90	Olanzapine	prolactin	MESH:C076029	5617	Chemical	Gene	shifts|nsubj|START_ENTITY shifts|dobj|relationship relationship|nmod|acrophase acrophase|nmod|END_ENTITY	Olanzapine shifts the temporal relationship between the daily acrophase of serum prolactin and cortisol concentrations rhythm in healthy men .
26655408	0	Oleacein	0,8	CD163	80,85	Oleacein	CD163	MESH:C578055	9332	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|expression expression|compound|END_ENTITY	Oleacein enhances anti-inflammatory activity of human macrophages by increasing CD163 receptor expression .
20298753	0	Oleamide	0,8	iNOS	61,65	Oleamide	iNOS	MESH:C029407	18126(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|nmod|END_ENTITY	Oleamide suppresses lipopolysaccharide-induced expression of iNOS and COX-2 through inhibition of NF-kappaB activation in BV2 murine microglial cells .
22584002	0	Oleamide	0,8	peroxisome_proliferator-activated_receptor_gamma	19,67	Oleamide	peroxisome proliferator-activated receptor gamma	MESH:C029407	19016(Tax:10090)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Oleamide activates peroxisome_proliferator-activated_receptor_gamma -LRB- PPARy -RRB- in vitro .
16889888	0	Oleanolic_acid	0,14	ABCC1	73,78	Oleanolic acid	ABCC1	MESH:D009828	4363	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	Oleanolic_acid inhibits the activity of the multidrug resistance protein ABCC1 -LRB- MRP1 -RRB- but not of the ABCB1 -LRB- P-glycoprotein -RRB- : possible use in cancer chemotherapy .
23603523	0	Oleanolic_acid	0,14	ANP	32,35	Oleanolic acid	ANP	MESH:D009828	24602(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|compound|END_ENTITY	Oleanolic_acid increases plasma ANP levels via an accentuation of cardiac ANP synthesis and secretion in rats .
23603523	0	Oleanolic_acid	0,14	ANP	74,77	Oleanolic acid	ANP	MESH:D009828	24602(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|nmod|accentuation accentuation|nmod|synthesis synthesis|compound|END_ENTITY	Oleanolic_acid increases plasma ANP levels via an accentuation of cardiac ANP synthesis and secretion in rats .
19283895	0	Oleanolic_acid	0,14	Nrf2	25,29	Oleanolic acid	Nrf2	MESH:D009828	18024(Tax:10090)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Oleanolic_acid activates Nrf2 and protects from acetaminophen hepatotoxicity via Nrf2-dependent and Nrf2-independent processes .
24393202	0	Oleanolic_acid	0,14	Nrf2	128,132	Oleanolic acid	Nrf2	MESH:D009828	18024(Tax:10090)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|nmod|mice mice|nmod|ureteral_obstruction ureteral_obstruction|acl|facilitating facilitating|dobj|translocation translocation|nmod|END_ENTITY	Oleanolic_acid attenuates renal fibrosis in mice with unilateral ureteral_obstruction via facilitating nuclear translocation of Nrf2 .
18707891	0	Oleanolic_acid	0,14	protein_tyrosine_phosphatase_1B	53,84	Oleanolic acid	protein tyrosine phosphatase 1B	MESH:D009828	5770	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	Oleanolic_acid and its derivatives : new inhibitor of protein_tyrosine_phosphatase_1B with cellular activities .
26521811	0	Oleic_Acid	21,31	Ghrelin	48,55	Oleic Acid	Ghrelin	MESH:D019301	58991(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|Production Production|compound|END_ENTITY	Inhibitory Effect of Oleic_Acid on Octanoylated Ghrelin Production .
14519521	0	Oleic_acid	0,10	GAP-43	19,25	Oleic acid	GAP-43	MESH:D019301	2596	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Oleic_acid induces GAP-43 expression through a protein kinase C-mediated mechanism that is independent of NGF but synergistic with NT-3 and NT-4 / 5 .
12670494	0	Oleic_acid	0,10	endothelin-1	19,31	Oleic acid	endothelin-1	MESH:D019301	1906	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Oleic_acid induces endothelin-1 expression through activation of protein_kinase_C and NF-kappa_B .
26892511	0	Oleic_acid	0,10	glucagon-like_peptide-1	22,45	Oleic acid	glucagon-like peptide-1	MESH:D019301	2641	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|amod|END_ENTITY	Oleic_acid stimulates glucagon-like_peptide-1 release from enteroendocrine cells by modulating cell respiration and glycolysis .
19699266	0	Oleic_acid	0,10	iNOS	60,64	Oleic acid	iNOS	MESH:D019301	18126(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|nmod|END_ENTITY	Oleic_acid reduces lipopolysaccharide-induced expression of iNOS and COX-2 in BV2 murine microglial cells : possible involvement of reactive oxygen species , p38_MAPK , and IKK/NF-kappaB signaling pathways .
14713277	0	Oleic_acid	0,10	insulin	54,61	Oleic acid	insulin	MESH:D019301	3630	Chemical	Gene	associated|csubjpass|START_ENTITY associated|nmod|resistance resistance|compound|END_ENTITY	Oleic_acid from cooking oils is associated with lower insulin resistance in the general population -LRB- Pizarra study -RRB- .
22911495	0	Oleifolioside_A	0,15	iNOS	66,70	Oleifolioside A	iNOS	MESH:C546794	4843	Chemical	Gene	Attenuates|nsubj|START_ENTITY Attenuates|dobj|END_ENTITY	Oleifolioside_A , a New Active Compound , Attenuates LPS-Stimulated iNOS and COX-2 Expression through the Downregulation of NF-kB and MAPK Activities in RAW 264.7 Macrophages .
22978602	0	Oleoyl-L-carnitine	0,18	GlyT2	49,54	Oleoyl-L-carnitine	GlyT2	null	2681	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Oleoyl-L-carnitine inhibits glycine transport by GlyT2 .
9864070	0	Oleoyl-estrone	0,14	neuropeptide_Y	43,57	Oleoyl-estrone	neuropeptide Y	MESH:C108709	24604(Tax:10116)	Chemical	Gene	alter|nsubj|START_ENTITY alter|dobj|END_ENTITY	Oleoyl-estrone does not alter hypothalamic neuropeptide_Y in Zucker lean and obese rats .
15123613	0	Oleoylethanolamide	0,18	PPAR-alpha	125,135	Oleoylethanolamide	PPAR-alpha	MESH:C488250	19013(Tax:10090)	Chemical	Gene	stimulates|amod|START_ENTITY lipolysis|nsubj|stimulates lipolysis|advcl|activating activating|dobj|peroxisome_proliferator-activated_receptor_alpha peroxisome_proliferator-activated_receptor_alpha|appos|END_ENTITY	Oleoylethanolamide stimulates lipolysis by activating the nuclear receptor peroxisome_proliferator-activated_receptor_alpha -LRB- PPAR-alpha -RRB- .
15910890	0	Oleoylethanolamide	0,18	PPAR-alpha	34,44	Oleoylethanolamide	PPAR-alpha	MESH:C488250	25747(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Oleoylethanolamide , an endogenous PPAR-alpha agonist , lowers body weight and hyperlipidemia in obese rats .
19345745	0	Oleoylethanolamide	0,18	PPAR-alpha	41,51	Oleoylethanolamide	PPAR-alpha	MESH:C488250	25747(Tax:10116)	Chemical	Gene	START_ENTITY|appos|ligand ligand|nmod|END_ENTITY	Oleoylethanolamide , a natural ligand for PPAR-alpha , inhibits insulin_receptor signalling in HTC rat hepatoma cells .
19345745	0	Oleoylethanolamide	0,18	insulin_receptor	62,78	Oleoylethanolamide	insulin receptor	MESH:C488250	24954(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Oleoylethanolamide , a natural ligand for PPAR-alpha , inhibits insulin_receptor signalling in HTC rat hepatoma cells .
15840558	0	Oligomycin	0,10	HIF-1alpha	20,30	Oligomycin	HIF-1alpha	MESH:D009840	3091	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Oligomycin inhibits HIF-1alpha expression in hypoxic_tumor cells .
1535627	0	Oligomycin	0,10	OSCP	43,47	Oligomycin	OSCP	MESH:D009840	281640(Tax:9913)	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Oligomycin sensitivity-conferring protein -LRB- OSCP -RRB- of mitochondrial ATP synthase .
23335397	0	Oligomycin_A	0,12	TRAIL	42,47	Oligomycin A	TRAIL	MESH:C031004	8743	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|effect effect|nmod|END_ENTITY	Oligomycin_A enhances apoptotic effect of TRAIL through CHOP-mediated death_receptor_5 expression .
18221453	0	Oligonol	0,8	COX-2	30,35	Oligonol	COX-2	MESH:C514283	17709(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Oligonol inhibits UVB-induced COX-2 expression in HR-1 hairless mouse skin -- AP-1 and C/EBP as potential upstream targets .
15879491	0	Olmesartan	0,10	AT1	20,23	Olmesartan	AT1	MESH:C437965	24180(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Olmesartan , a novel AT1 antagonist , suppresses cytotoxic_myocardial_injury in autoimmune_heart_failure .
21383952	0	Olmesartan	0,10	AT1	15,18	Olmesartan	AT1	MESH:C437965	24180(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Olmesartan , an AT1 antagonist , attenuates oxidative stress , endoplasmic_reticulum_stress and cardiac inflammatory mediators in rats with heart_failure induced by experimental autoimmune_myocarditis .
26089622	0	Olmesartan	176,186	Angiotensin-II	88,102	Olmesartan	Angiotensin-II	MESH:C437965	183	Chemical	Gene	Combination|compound|START_ENTITY Interaction|nmod|Combination Application|nmod|Interaction Development|dep|Application Development|nmod|Spectrometry Spectrometry|nmod|END_ENTITY	Method Development and Validation of Liquid Chromatography-Tandem Mass Spectrometry for Angiotensin-II in Human Plasma : Application to Study Interaction Between Atorvastatin _ Olmesartan Drug Combination .
23355126	0	Olmesartan	94,104	Angiotensin_II_Type_1_Receptor	41,71	Olmesartan	Angiotensin II Type 1 Receptor	MESH:C437965	185	Chemical	Gene	Medoxomil|compound|START_ENTITY Focus|nmod|Medoxomil Reduction|dep|Focus Reduction|nmod|Antagonism Antagonism|compound|END_ENTITY	Reduction of Cardiovascular Risk through Angiotensin_II_Type_1_Receptor Antagonism : Focus on Olmesartan Medoxomil .
20508392	5	Olmesartan	849,859	ERK1/2	882,888	Olmesartan	ERK1/2	MESH:C437965	5595;5594	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|dobj|END_ENTITY	Olmesartan inhibited AII-induced ERK1/2 and JNK activation at lower concentrations -LRB- 10 nM -RRB- .
23775504	0	Olmesartan	0,10	IL-1b	21,26	Olmesartan	IL-1b	MESH:C437965	24494(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|END_ENTITY	Olmesartan decreases IL-1b and TNF-a levels ; downregulates MMP-2 , MMP-9 , COX-2 , and RANKL ; and upregulates OPG in experimental periodontitis .
25531650	0	Olmesartan	0,10	IL-1b	31,36	Olmesartan	IL-1b	MESH:C437965	24494(Tax:10116)	Chemical	Gene	Levels|compound|START_ENTITY Levels|nmod|RANK/RANKL RANK/RANKL|dep|END_ENTITY	Olmesartan Decreased Levels of IL-1b and TNF-a , Down-Regulated MMP-2 , MMP-9 , COX-2 , RANK/RANKL and Up-Regulated SOCs-1 in an Intestinal Mucositis Model .
25806956	0	Olmesartan	12,22	IL-1b	43,48	Olmesartan	IL-1b	MESH:C437965	3553	Chemical	Gene	Levels|compound|START_ENTITY Levels|nmod|RANK/RANKL RANK/RANKL|compound|END_ENTITY	Correction : Olmesartan Decreased Levels of IL-1b and TNF-a , Down-Regulated MMP-2 , MMP-9 , COX-2 , RANK/RANKL and Up-Regulated SOCs-1 in an Intestinal Mucositis Model .
25806956	0	Olmesartan	12,22	MMP-2	75,80	Olmesartan	MMP-2	MESH:C437965	4313	Chemical	Gene	Levels|compound|START_ENTITY Levels|nmod|RANK/RANKL RANK/RANKL|compound|END_ENTITY	Correction : Olmesartan Decreased Levels of IL-1b and TNF-a , Down-Regulated MMP-2 , MMP-9 , COX-2 , RANK/RANKL and Up-Regulated SOCs-1 in an Intestinal Mucositis Model .
15291378	0	Olmesartan	0,10	angiotensin_II	31,45	Olmesartan	angiotensin II	MESH:C437965	183	Chemical	Gene	START_ENTITY|nmod|antagonists antagonists|amod|END_ENTITY	Olmesartan compared with other angiotensin_II receptor antagonists : head-to-head trials .
17345786	0	Olmesartan	0,10	angiotensin_II	17,31	Olmesartan	angiotensin II	MESH:C437965	24179(Tax:10116)	Chemical	Gene	blocker|nsubj|START_ENTITY blocker|amod|END_ENTITY	Olmesartan is an angiotensin_II receptor blocker with an inhibitory effect on angiotensin-converting_enzyme .
19171689	0	Olmesartan	0,10	angiotensin_II	103,117	Olmesartan	angiotensin II	MESH:C437965	24179(Tax:10116)	Chemical	Gene	improves|nsubj|START_ENTITY improves|dep|ventricular ventricular|advcl|blocking blocking|dobj|receptor receptor|amod|END_ENTITY	Olmesartan improves left ventricular function in pressure-overload hypertrophied rat heart by blocking angiotensin_II receptor with synergic effects of upregulation of angiotensin converting enzyme 2 .
22288300	0	Olmesartan	10,20	cystatin_C	30,40	Olmesartan	cystatin C	MESH:C437965	1471	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|amod|END_ENTITY	Effect of Olmesartan on serum cystatin_C levels in the patients with essential hypertension .
14728822	0	Olmesartan	0,10	monocyte_chemoattractant_protein-1	38,72	Olmesartan	monocyte chemoattractant protein-1	MESH:C437965	20296(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Olmesartan inhibits the expression of monocyte_chemoattractant_protein-1 and tumor_necrosis_factor-alpha and improves vascular remodeling after vascular_injury in mouse .
15929605	0	Olmesartan_medoxomil	0,20	angiotensin_II_type_1_receptor	40,70	Olmesartan medoxomil	angiotensin II type 1 receptor	MESH:C097933	81638(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Olmesartan_medoxomil , a newly developed angiotensin_II_type_1_receptor antagonist , protects against renal_damage in advanced glycation end product -LRB- age -RRB- - injected rats .
24116053	0	Olomoucine_II	0,13	breast_cancer_resistance_protein	55,87	Olomoucine II	breast cancer resistance protein	MESH:C475587	9429	Chemical	Gene	transported|nsubjpass|START_ENTITY transported|nmod|END_ENTITY	Olomoucine_II , but not purvalanol_A , is transported by breast_cancer_resistance_protein -LRB- ABCG2 -RRB- and P-glycoprotein -LRB- ABCB1 -RRB- .
10831003	0	Olopatadine	0,11	TNFalpha	21,29	Olopatadine	TNFalpha	MESH:C074921	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|compound|END_ENTITY	Olopatadine inhibits TNFalpha release from human conjunctival mast cells .
21035441	0	Olprinone	0,9	PDE3	13,17	Olprinone	PDE3	MESH:C059498	498900(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Olprinone , a PDE3 inhibitor , modulates the inflammation associated with myocardial_ischemia-reperfusion injury in rats .
7554069	0	Oltipraz	28,36	BOP	77,80	Oltipraz	BOP	MESH:C026209	100294715	Chemical	Gene	activity|nmod|START_ENTITY activity|appos|END_ENTITY	Chemopreventive activity of Oltipraz against N-nitrosobis -LRB- 2-oxopropyl -RRB- amine -LRB- BOP -RRB- - induced ductal_pancreatic_carcinoma development and effects on survival of Syrian_golden_hamsters .
24660890	0	Omarigliptin	0,12	DPP-4	44,49	Omarigliptin	DPP-4	null	1803	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Omarigliptin -LRB- MK-3102 -RRB- : a novel long-acting DPP-4 inhibitor for once-weekly treatment of type 2 diabetes .
25557903	0	Omega-3_Fatty_Acid	0,18	Chia	80,84	Omega-3 Fatty Acid	Chia	CHEBI:25681	27159	Chemical	Gene	Profile|compound|START_ENTITY Profile|nmod|END_ENTITY	Omega-3_Fatty_Acid Profile of Eggs from Laying Hens Fed Diets Supplemented with Chia , Fish Oil , and Flaxseed .
25691459	0	Omega-3_Polyunsaturated_Fatty_Acids	0,35	15-PGDH	47,54	Omega-3 Polyunsaturated Fatty Acids	15-PGDH	null	3248	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Omega-3_Polyunsaturated_Fatty_Acids Upregulate 15-PGDH Expression in Cholangiocarcinoma Cells by Inhibiting miR-26a / b Expression .
15899837	0	Omega-3_polyunsaturated_fatty_acids	0,35	syndecan-1	45,55	Omega-3 polyunsaturated fatty acids	syndecan-1	null	6382	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|amod|END_ENTITY	Omega-3_polyunsaturated_fatty_acids regulate syndecan-1 expression in human breast_cancer cells .
11736724	0	Omeprazole	121,131	CYP2C19	11,18	Omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	metabolized|nsubjpass|START_ENTITY BACKGROUND|parataxis|metabolized BACKGROUND|nsubj|Effects Effects|nmod|differences differences|nummod|END_ENTITY	Effects of CYP2C19 genotypic differences in the metabolism of omeprazole and rabeprazole on intragastric pH. BACKGROUND : Omeprazole is mainly metabolized in the liver by CYP2C19 , a genetically determined enzyme , whereas rabeprazole is mainly reduced non-enzymatically and partially metabolized by CYP2C19 .
11966672	0	Omeprazole	0,10	CYP2C19	101,108	Omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	hydroxylation|amod|START_ENTITY inhibited|nsubjpass|hydroxylation inhibited|nmod|genotype genotype|nmod|END_ENTITY	Omeprazole hydroxylation is inhibited by a single dose of moclobemide in homozygotic EM genotype for CYP2C19 .
15145965	0	Omeprazole	0,10	CYP2C19	16,23	Omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	START_ENTITY|nmod|marker marker|compound|END_ENTITY	Omeprazole as a CYP2C19 marker in Chinese subjects : assessment of its gene-dose effect and intrasubject variability .
23185525	0	Omeprazole	0,10	STAT6	18,23	Omeprazole	STAT6	MESH:D009853	6778	Chemical	Gene	blocks|amod|START_ENTITY END_ENTITY|nsubj|blocks	Omeprazole blocks STAT6 binding to the eotaxin-3 promoter in eosinophilic_esophagitis cells .
22009190	0	Omeprazole	0,10	cytochrome_P450_2C19	115,135	Omeprazole	cytochrome P450 2C19	MESH:D009853	1557	Chemical	Gene	START_ENTITY|parataxis|phenotyping phenotyping|nsubj|implications implications|nmod|END_ENTITY	Omeprazole limited sampling strategies to predict area under the concentration-time curve ratios : implications for cytochrome_P450_2C19 and 3A phenotyping .
11069321	0	Omeprazole	0,10	gastrin	71,78	Omeprazole	gastrin	MESH:D009853	2520	Chemical	Gene	polymorphism|amod|START_ENTITY polymorphism|dep|effects effects|nmod|treatment treatment|nmod|END_ENTITY	Omeprazole and CYP2C19 polymorphism : effects of long-term treatment on gastrin , pepsinogen I , and chromogranin_A in patients with acid related disorders .
19187764	0	Oncogenic_B-RAF	0,15	LKB1	58,62	Oncogenic B-RAF	LKB1	null	6794	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Oncogenic_B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation .
7936118	0	Ondansetron	0,11	5-HT3_receptor	25,39	Ondansetron	5-HT3 receptor	MESH:D017294	79246(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Ondansetron , a selective 5-HT3_receptor antagonist , reduces palatable food consumption in the nondeprived rat .
1838490	0	Ondansetron	1,12	5-HT3_serotonin_receptor	25,49	Ondansetron	5-HT3 serotonin receptor	MESH:D017294	3359	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	-LSB- Ondansetron : a specific 5-HT3_serotonin_receptor inhibitor , a new antiemetic in oncology -RSB- .
8874872	0	Opiate	0,6	ProTRH	28,34	Opiate	ProTRH	null	7200	Chemical	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	Opiate withdrawal increases ProTRH gene expression in the ventrolateral column of the midbrain periaqueductal gray .
23336248	0	Opicapone	0,9	catechol-O-methyltransferase	52,80	Opicapone	catechol-O-methyltransferase	MESH:C549349	1312	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Opicapone : a short lived and very long acting novel catechol-O-methyltransferase inhibitor following multiple dose administration in healthy subjects .
26322210	0	Opium	39,44	Interleukin-6	65,78	Opium	Interleukin-6	MESH:D009892	3569	Chemical	Gene	START_ENTITY|nmod|Secretion Secretion|nmod|END_ENTITY	Effects of Different Concentrations of Opium on the Secretion of Interleukin-6 , Interferon-y and Transforming_Growth_Factor_Beta Cytokines from Jurkat Cells .
20725779	0	Org-24461	141,150	glycine_transporter_type-1	104,130	Org-24461	glycine transporter type-1	null	116509(Tax:10116)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Alterations in brain extracellular dopamine and glycine levels following combined administration of the glycine_transporter_type-1 inhibitor Org-24461 and risperidone .
19939872	0	Org_26828	84,93	CB1	63,66	Org 26828	CB1	MESH:C556130	1268	Chemical	Gene	agonist|dobj|START_ENTITY agonist|nsubj|effects effects|nmod|receptor receptor|compound|END_ENTITY	Pharmacodynamic and pharmacokinetic effects of the intravenous CB1 receptor agonist Org_26828 in healthy male volunteers .
26996418	0	Organokines	14,25	Insulin	29,36	Organokines	Insulin	null	3630	Chemical	Gene	Impact|nmod|START_ENTITY Impact|nmod|Resistance Resistance|compound|END_ENTITY	The Impact of Organokines on Insulin Resistance , Inflammation , and Atherosclerosis .
23712004	0	Oridonin	0,8	B-cell_activating_factor	79,103	Oridonin	B-cell activating factor	MESH:C011959	24099(Tax:10090)	Chemical	Gene	ameliorates|nsubj|START_ENTITY ameliorates|nmod|inhibition inhibition|nmod|END_ENTITY	Oridonin ameliorates lupus-like symptoms of MRL -LRB- lpr/lpr -RRB- mice by inhibition of B-cell_activating_factor -LRB- BAFF -RRB- .
25447156	0	Oridonin	0,8	cystic_fibrosis_transmembrane_conductance_regulator	40,91	Oridonin	cystic fibrosis transmembrane conductance regulator	MESH:C011959	12638(Tax:10090)	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	Oridonin : A small molecule inhibitor of cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- isolated from traditional Chinese medicine .
25075795	0	Oridonin	0,8	mTOR	18,22	Oridonin	mTOR	MESH:C011959	21977(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Oridonin inhibits mTOR signaling and the growth of lung_cancer_tumors .
26925661	0	Oridonin	0,8	mTOR	80,84	Oridonin	mTOR	MESH:C011959	21977(Tax:10090)	Chemical	Gene	Proliferation|compound|START_ENTITY Proliferation|nmod|Signaling Signaling|compound|END_ENTITY	Oridonin Suppresses Proliferation of Human Ovarian_Cancer Cells via Blockage of mTOR Signaling .
24297112	0	Oridonin	0,8	p53	65,68	Oridonin	p53	MESH:C011959	7157	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|apoptosis apoptosis|nmod|cells cells|nmod|END_ENTITY	Oridonin induces apoptosis in SW1990 pancreatic_cancer cells via p53 - and caspase-dependent induction of p38 MAPK .
25886043	0	Oridonin	0,8	retinoic_acid_receptor_alpha	20,48	Oridonin	retinoic acid receptor alpha	MESH:C011959	5914	Chemical	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	Oridonin stabilizes retinoic_acid_receptor_alpha through ROS-activated NF-kB signaling .
21442799	3	Orlistat	582,590	ES-31	615,620	Orlistat	ES-31	MESH:C055122	23491	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	METHODS : Effect of HIV-protease inhibitors namely Ritonavir , Lopinavir and Indinavir and Orlistat on protease activity of ES-31 was assessed using azocasein assay and on bacillary growth in axenic culture of Mycobacterium_tuberculosis_H37Ra .
12738478	0	Orlistat	0,8	NASH	29,33	Orlistat	NASH	MESH:C055122	64092	Chemical	Gene	START_ENTITY|nmod|treatment treatment|nmod|END_ENTITY	Orlistat in the treatment of NASH : a case series .
20683173	0	Orlistat	0,8	insulin	55,62	Orlistat	insulin	MESH:C055122	3630	Chemical	Gene	compared|nsubj|START_ENTITY compared|xcomp|orlistat orlistat|nmod|resistance resistance|compound|END_ENTITY	Orlistat and L-carnitine compared to orlistat alone on insulin resistance in obese diabetic patients .
24508576	0	Orlistat	53,61	lipase	95,101	Orlistat	lipase	MESH:C055122	404010(Tax:9615)	Chemical	Gene	Using|nmod|START_ENTITY END_ENTITY|csubj|Using	Using the reversible inhibition of gastric_lipase by Orlistat for investigating simultaneously lipase adsorption and substrate hydrolysis at the lipid-water interface .
2080662	0	Ornithine	0,9	SPE1	103,107	Ornithine	SPE1	CHEBI:18257	853651(Tax:4932)	Chemical	Gene	decarboxylase|amod|START_ENTITY decarboxylase|dep|assignment assignment|nmod|gene gene|compound|END_ENTITY	Ornithine decarboxylase in Saccharomyces_cerevisiae : chromosomal assignment and genetic mapping of the SPE1 gene .
11007319	0	Ornithine	0,9	ornithine_decarboxylase	69,92	Ornithine	ornithine decarboxylase	CHEBI:18257	18263(Tax:10090)	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|dep|localization localization|nmod|END_ENTITY	Ornithine metabolism along the female mouse nephron : localization of ornithine_decarboxylase and ornithine_aminotransferase .
21207971	0	Oroidin	0,7	Pdr5p	65,70	Oroidin	Pdr5p	MESH:C077209	854324(Tax:4932)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	Oroidin inhibits the activity of the multidrug resistance target Pdr5p from yeast plasma membranes .
21145362	0	Oroxylin_A	0,10	BDNF	21,25	Oroxylin A	BDNF	MESH:C080669	24225(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|production production|amod|END_ENTITY	Oroxylin_A increases BDNF production by activation of MAPK-CREB pathway in rat primary cortical neuronal culture .
24116271	0	Oroxylin_A	0,10	BDNF	19,23	Oroxylin A	BDNF	MESH:C080669	627	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Oroxylin_A Induces BDNF Expression on Cortical Neurons through Adenosine_A2A_Receptor Stimulation : A Possible Role in Neuroprotection .
23823704	0	Oroxylin_A	0,10	IL-6	77,81	Oroxylin A	IL-6	MESH:C080669	3569	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|modulating modulating|dobj|STAT3 STAT3|compound|END_ENTITY	Oroxylin_A inhibits colitis-associated_carcinogenesis through modulating the IL-6 / STAT3 signaling pathway .
25192658	0	Oroxylin_A	0,10	IL-6	33,37	Oroxylin A	IL-6	MESH:C080669	3569	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Oroxylin_A inhibits ATRA-induced IL-6 expression involved in retinoic_acid syndrome by down-regulating CHOP .
25218897	0	Oroxylin_A	0,10	brain-derived_neurotrophic_factor	53,86	Oroxylin A	brain-derived neurotrophic factor	MESH:C080669	12064(Tax:10090)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Oroxylin_A enhances memory consolidation through the brain-derived_neurotrophic_factor in mice .
23922737	0	Oroxylin_A	44,54	estrogen_receptor	3,20	Oroxylin A	estrogen receptor	MESH:C080669	2099	Chemical	Gene	mechanism|nmod|START_ENTITY mechanism|amod|END_ENTITY	An estrogen_receptor dependent mechanism of Oroxylin_A in the repression of inflammatory response .
10751555	0	Oroxylin_A	0,10	iNOS	52,56	Oroxylin A	iNOS	MESH:C080669	18126(Tax:10090)	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	Oroxylin_A inhibition of lipopolysaccharide-induced iNOS and COX-2 gene expression via suppression of nuclear_factor-kappaB activation .
25297456	0	Orteronel	26,35	CYP17A1	43,50	Orteronel	CYP17A1	MESH:C571806	25146(Tax:10116)	Chemical	Gene	-RRB-|compound|START_ENTITY -RRB-|appos|END_ENTITY	Preclinical assessment of Orteronel -LRB- -RRB- , a CYP17A1 enzyme inhibitor in rats .
21672546	0	Ortho-aminoazotoluene	0,21	constitutive_androstane_receptor	38,70	Ortho-aminoazotoluene	constitutive androstane receptor	MESH:D009762	12355(Tax:10090)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Ortho-aminoazotoluene activates mouse constitutive_androstane_receptor -LRB- mCAR -RRB- and increases expression of mCAR target genes .
11305589	0	Orthovanadate	0,13	leptin	24,30	Orthovanadate	leptin	MESH:D014638	16846(Tax:10090)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|secretion secretion|compound|END_ENTITY	Orthovanadate decreases leptin secretion from isolated mouse fat pads .
12361713	0	Orthovanadate	0,13	leptin	28,34	Orthovanadate	leptin	MESH:D014638	16846(Tax:10090)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|content content|compound|END_ENTITY	Orthovanadate decreases the leptin content in isolated mouse fat pads via proteasome activation .
15187419	0	Orthovanadate	0,13	phosphodiesterase_3	30,49	Orthovanadate	phosphodiesterase 3	MESH:D014638	498900(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|amod|END_ENTITY	Orthovanadate stimulates cAMP phosphodiesterase_3 activity in isolated rat hepatocytes through mitogen-activated protein kinase activation dependent on cAMP-dependent protein kinase .
15147766	0	Osa	0,3	Apterous	32,40	Osa	Apterous	null	35509(Tax:7227)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|genes genes|compound|END_ENTITY	Osa modulates the expression of Apterous target genes in the Drosophila wing .
17312105	0	Oseltamivir	14,25	GM1	43,46	Oseltamivir	GM1	MESH:D053139	210582(Tax:10090)	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Cutting Edge : Oseltamivir decreases T cell GM1 expression and inhibits clearance of respiratory_syncytial_virus : potential role of endogenous sialidase in antiviral immunity .
24564719	0	Oseltamivir	132,143	Neuraminidase	58,71	Oseltamivir	Neuraminidase	MESH:D053139	4758	Chemical	Gene	inhibitors|dobj|START_ENTITY inhibitors|nsubj|analysis analysis|nmod|A A|dep|interactions interactions|amod|END_ENTITY	Structural analysis of the novel influenza A -LRB- H7N9 -RRB- viral Neuraminidase interactions with current approved neuraminidase inhibitors Oseltamivir , Zanamivir , and Peramivir in the presence of mutation R289K .
26100715	0	Oseltamivir	46,57	Neuraminidase	58,71	Oseltamivir	Neuraminidase	MESH:D053139	4758	Chemical	Gene	Inhibition|compound|START_ENTITY Inhibition|compound|END_ENTITY	A Drug-Disease Model Describing the Effect of Oseltamivir Neuraminidase Inhibition on Influenza Virus Progression .
26921415	0	Oseltamivir	72,83	Neuraminidase	84,97	Oseltamivir	Neuraminidase	MESH:D053139	4758	Chemical	Gene	Inhibition|compound|START_ENTITY Inhibition|compound|END_ENTITY	Erratum for Kamal et al. , A Drug-Disease Model Describing the Effect of Oseltamivir Neuraminidase Inhibition on Influenza Virus Progression .
19943705	0	Oseltamivir	0,11	neuraminidase	37,50	Oseltamivir	neuraminidase	MESH:D053139	4758	Chemical	Gene	resistance|amod|START_ENTITY END_ENTITY|nsubj|resistance	Oseltamivir resistance and the H274Y neuraminidase mutation in seasonal , pandemic and highly pathogenic influenza viruses .
20300625	8	Oseltamivir	1270,1281	neuraminidase	1155,1168	Oseltamivir	neuraminidase	MESH:D053139	4758	Chemical	Gene	possessed|nmod|START_ENTITY possessed|nsubj|END_ENTITY	The neuraminidase of all the Indian isolates possessed H275 , the marker for sensitivity to the neuraminidase inhibitor Oseltamivir .
22105586	0	Oseltamivir	0,11	neuraminidase	26,39	Oseltamivir	neuraminidase	MESH:D053139	4758	Chemical	Gene	START_ENTITY|appos|drug drug|amod|END_ENTITY	Oseltamivir , an influenza neuraminidase inhibitor drug , does not affect the steady-state pharmacokinetic characteristics of cyclosporine , mycophenolate , or tacrolimus in adult renal transplant patients .
22332369	0	Oseltamivir	1,12	neuraminidase	66,79	Oseltamivir	neuraminidase	MESH:D053139	4758	Chemical	Gene	resistance|compound|START_ENTITY depends|nsubj|resistance depends|nmod|amino_acid amino_acid|nmod|END_ENTITY	-LSB- Oseltamivir resistance depends on the position 273 amino_acid of neuraminidase of the type A influenza virus -LRB- H1N1 -RRB- , circulating in human population -RSB- .
24564719	0	Oseltamivir	132,143	neuraminidase	107,120	Oseltamivir	neuraminidase	MESH:D053139	4758	Chemical	Gene	inhibitors|dobj|START_ENTITY inhibitors|nsubj|analysis analysis|nmod|A A|dep|interactions interactions|nmod|END_ENTITY	Structural analysis of the novel influenza A -LRB- H7N9 -RRB- viral Neuraminidase interactions with current approved neuraminidase inhibitors Oseltamivir , Zanamivir , and Peramivir in the presence of mutation R289K .
24649802	0	Oseltamivir	0,11	neuraminidase	65,78	Oseltamivir	neuraminidase	MESH:D053139	4758	Chemical	Gene	analogues|nsubj|START_ENTITY analogues|xcomp|bearing bearing|dobj|N-substituted_guanidines N-substituted_guanidines|nmod|inhibitors inhibitors|compound|END_ENTITY	Oseltamivir analogues bearing N-substituted_guanidines as potent neuraminidase inhibitors .
19439487	0	Oseltamivir	0,11	peptide_transporter_1	40,61	Oseltamivir	peptide transporter 1	MESH:D053139	6564	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Oseltamivir -LRB- tamiflu -RRB- is a substrate of peptide_transporter_1 .
26099282	0	Osteopontin	0,11	vascular_endothelial_growth_factor	20,54	Osteopontin	vascular endothelial growth factor	MESH:D053495	83785(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Osteopontin induces vascular_endothelial_growth_factor expression in articular cartilage through PI3K/AKT and ERK1/2 signaling .
16807298	0	Ouabain	0,7	Akt	80,83	Ouabain	Akt	MESH:D010042	207	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Ouabain induces cell proliferation through calcium-dependent phosphorylation of Akt -LRB- protein kinase B -RRB- in opossum kidney proximal tubule cells .
17634416	0	Ouabain	0,7	Akt	37,40	Ouabain	Akt	MESH:D010042	207	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|B B|appos|END_ENTITY	Ouabain stimulates protein kinase B -LRB- Akt -RRB- phosphorylation in opossum kidney proximal tubule cells through an ERK-dependent pathway .
3025550	0	Ouabain	0,7	PTH	48,51	Ouabain	PTH	MESH:D010042	280903(Tax:9913)	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|secretion secretion|compound|END_ENTITY	Ouabain and low extracellular potassium inhibit PTH secretion from bovine parathyroid cells by a mechanism that does not involve increases in the cytosolic calcium concentration .
18703152	0	Ouabain	0,7	p38	17,20	Ouabain	p38	MESH:D010042	1432	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	Ouabain inhibits p38 activation in thymocytes .
2851525	0	Ovine	0,5	corticotropin-releasing_hormone	6,37	Ovine	corticotropin-releasing hormone	null	1392	Chemical	Gene	test|amod|START_ENTITY test|amod|END_ENTITY	Ovine corticotropin-releasing_hormone stimulation test in patients with chronic_renal_failure : pharmacokinetic properties , and plasma adrenocorticotropic_hormone and serum cortisol responses .
24068192	0	Ox-LDL	0,6	OX40L	17,22	Ox-LDL	OX40L	CHEBI:60151	7292	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Ox-LDL increases OX40L in endothelial cells through a LOX-1-dependent mechanism .
19269817	0	Oxadiazole-diarylpyrazole_4-carboxamides	0,40	CB1	56,59	Oxadiazole-diarylpyrazole 4-carboxamides	CB1	null	1268	Chemical	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	Oxadiazole-diarylpyrazole_4-carboxamides as cannabinoid CB1 receptor ligands .
16014026	0	Oxalate	0,7	IL-6	19,23	Oxalate	IL-6	null	3569	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|compound|END_ENTITY	Oxalate stimulates IL-6 production in HK-2 cells , a line of human renal proximal tubular epithelial cells .
16307291	0	Oxalate	0,7	MCP-1	66,71	Oxalate	MCP-1	null	6347	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Oxalate induced expression of monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- in HK-2 cells involves reactive oxygen species .
25723812	0	Oxaliplatin	39,50	ERCC1	23,28	Oxaliplatin	ERCC1	MESH:C030110	2067	Chemical	Gene	Status|nmod|START_ENTITY Status|compound|END_ENTITY	The Predictive Role of ERCC1 Status in Oxaliplatin Based Neoadjuvant Therapy for Metastatic Colorectal_Cancer -LRB- mCRC -RRB- to the Liver .
21683075	0	Oxaliplatin	0,11	TRAIL	51,56	Oxaliplatin	TRAIL	MESH:C030110	8743	Chemical	Gene	sensitizes|nsubj|START_ENTITY sensitizes|xcomp|END_ENTITY	Oxaliplatin sensitizes human colon_cancer cells to TRAIL through JNK-dependent phosphorylation of Bcl-xL .
17257628	0	Oxalomalate	0,11	inducible_nitric_oxide_synthase	24,55	Oxalomalate	inducible nitric oxide synthase	MESH:C015407	24599(Tax:10116)	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|expression expression|amod|END_ENTITY	Oxalomalate affects the inducible_nitric_oxide_synthase expression and activity .
3453497	0	Oxandrolone	0,11	growth_hormone	54,68	Oxandrolone	growth hormone	MESH:D010074	2688	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|rise rise|nmod|secretion secretion|compound|END_ENTITY	Oxandrolone induces a sustained rise in physiological growth_hormone secretion in boys with constitutional_delay_of_growth and puberty .
16359173	0	Oxanosine	0,9	adenosine_deaminase	28,47	Oxanosine	adenosine deaminase	MESH:C032886	100	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Oxanosine is a substrate of adenosine_deaminase .
26812276	0	Oxaspirol_B	0,11	p97	17,20	Oxaspirol B	p97	null	4241	Chemical	Gene	START_ENTITY|nmod|Activity Activity|amod|END_ENTITY	Oxaspirol_B with p97 Inhibitory Activity and Other Oxaspirols from Lecythophora sp .
20236836	0	Oxazolone	0,9	Leu-enkephalin	43,57	Oxazolone	Leu-enkephalin	MESH:D010081	5173	Chemical	Gene	START_ENTITY|nmod|structures structures|nmod|END_ENTITY	Oxazolone versus macrocycle structures for Leu-enkephalin b2-b4 : insights from infrared multiple-photon_dissociation spectroscopy and gas-phase hydrogen/deuterium exchange .
16750372	0	Oxazolones	0,10	tyrosinase	16,26	Oxazolones	tyrosinase	null	7299	Chemical	Gene	START_ENTITY|dep|inhibitors inhibitors|compound|END_ENTITY	Oxazolones : new tyrosinase inhibitors ; synthesis and their structure-activity relationships .
17020759	0	Oxidized_ATP	0,12	beta-actin	23,33	Oxidized ATP	beta-actin	MESH:C017199	728378	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|amod|END_ENTITY	Oxidized_ATP decreases beta-actin expression and intracellular superoxide concentrations in RBA-2 type-2 astrocytes independently of P2X7_receptor .
23959117	0	Oximes	0,6	acetylcholinesterase	40,60	Oximes	acetylcholinesterase	MESH:D010091	43	Chemical	Gene	START_ENTITY|dep|inhibitors inhibitors|nmod|END_ENTITY	Oximes : inhibitors of human recombinant acetylcholinesterase .
21316225	0	Oxindole	0,8	TAK1	38,42	Oxindole	TAK1	MESH:C508198	6885	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|inhibitors inhibitors|nmod|END_ENTITY	Oxindole derivatives as inhibitors of TAK1 kinase .
6104819	0	Oxotremorine	48,60	tyrosine_hydroxylase	15,35	Oxotremorine	tyrosine hydroxylase	MESH:D010095	25085(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Enhancement of tyrosine_hydroxylase activity by Oxotremorine does not affect sleep in the rat .
7589090	0	Oxpentifylline	0,14	tumor_necrosis_factor-alpha	24,51	Oxpentifylline	tumor necrosis factor-alpha	MESH:D010431	24835(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|transcription transcription|amod|END_ENTITY	Oxpentifylline inhibits tumor_necrosis_factor-alpha mRNA transcription and protects against arthritis in mercuric_chloride-treated brown Norway_rats .
25518025	0	Oxycodone	42,51	CYP2D6	56,62	Oxycodone	CYP2D6	MESH:D010098	1565	Chemical	Gene	START_ENTITY|nmod|Inhibition Inhibition|compound|END_ENTITY	Prediction of Metabolic Interactions With Oxycodone via CYP2D6 and CYP3A Inhibition Using a Physiologically Based Pharmacokinetic Model .
2977133	0	Oxygen	0,6	ATPase	118,124	Oxygen	ATPase	MESH:D010100	1769	Chemical	Gene	exchange|compound|START_ENTITY exchange|dep|evidence evidence|nmod|mechanism mechanism|nmod|reaction reaction|compound|END_ENTITY	Oxygen exchange during the acto-subfragment-1 ATPase reaction : evidence for the two-route mechanism of the actomyosin ATPase reaction .
2977133	0	Oxygen	0,6	ATPase	46,52	Oxygen	ATPase	MESH:D010100	1769	Chemical	Gene	exchange|compound|START_ENTITY exchange|nmod|reaction reaction|compound|END_ENTITY	Oxygen exchange during the acto-subfragment-1 ATPase reaction : evidence for the two-route mechanism of the actomyosin ATPase reaction .
25666039	0	Oxygen	100,106	Albumin	51,58	Oxygen	Albumin	MESH:D010100	213	Chemical	Gene	Species|compound|START_ENTITY END_ENTITY|nmod|Species	Curcumin Mitigates The Fibrillation Of Human Serum Albumin And Diminishes The Formation Of Reactive Oxygen Species .
22452597	0	Oxygen	0,6	BCL-2	142,147	Oxygen	BCL-2	MESH:D010100	102402077	Chemical	Gene	concentration|amod|START_ENTITY affect|nsubj|concentration affect|dobj|expression expression|nmod|END_ENTITY	Oxygen concentration and cysteamine supplementation during in vitro production of buffalo -LRB- Bubalus_bubalis -RRB- embryos affect mRNA expression of BCL-2 , BCL-XL , MCL-1 , BAX and BID .
19592481	0	Oxygen	25,31	Bax	50,53	Oxygen	Bax	MESH:D010100	581	Chemical	Gene	Translocation|compound|START_ENTITY Translocation|compound|END_ENTITY	Bufalin Induces Reactive Oxygen Species Dependent Bax Translocation and Apoptosis in ASTC-a-1 Cells .
25861655	0	Oxygen	110,116	Bax	131,134	Oxygen	Bax	MESH:D010100	24887(Tax:10116)	Chemical	Gene	-2|compound|START_ENTITY Related|nmod|-2 Effects|nmod|Related Effects|dep|Pathway Pathway|compound|END_ENTITY	Protective Effects of Scutellarin on Type_II_Diabetes_Mellitus-Induced Testicular Damages Related to Reactive Oxygen Species/Bcl -2 / Bax and Reactive Oxygen Species/Microcirculation/Staving Pathway in Diabetic Rat .
25861655	0	Oxygen	148,154	Bax	131,134	Oxygen	Bax	MESH:D010100	24887(Tax:10116)	Chemical	Gene	Pathway|compound|START_ENTITY Pathway|compound|END_ENTITY	Protective Effects of Scutellarin on Type_II_Diabetes_Mellitus-Induced Testicular Damages Related to Reactive Oxygen Species/Bcl -2 / Bax and Reactive Oxygen Species/Microcirculation/Staving Pathway in Diabetic Rat .
27070098	0	Oxygen	25,31	Bcl-2	0,5	Oxygen	Bcl-2	MESH:D010100	12043(Tax:10090)	Chemical	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	Bcl-2 Regulates Reactive Oxygen Species Signaling and a Redox-Sensitive Mitochondrial Proton Leak in Mouse Pancreatic b-cells .
22741033	0	Oxygen	77,83	CD133	102,107	Oxygen	CD133	MESH:D010100	8842	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	A Prominin-1-Rich Pediatric_Glioblastoma : Biologic Behavior Is Determined by Oxygen Tension-Modulated CD133 Expression but Not Accompanied by Underlying Molecular Profiles .
19885004	0	Oxygen	135,141	CD36	48,52	Oxygen	CD36	MESH:D010100	12491(Tax:10090)	Chemical	Gene	Production|compound|START_ENTITY Expression|nmod|Production Expression|compound|END_ENTITY	Cilostazol Attenuates 4-hydroxynonenal-enhanced CD36 Expression on Murine Macrophages via Inhibition of NADPH Oxidase-derived Reactive Oxygen Species Production .
25477423	0	Oxygen	0,6	COPD	72,76	Oxygen	COPD	MESH:D010100	260431	Chemical	Gene	mismatch|amod|START_ENTITY mismatch|nmod|muscle muscle|nmod|END_ENTITY	Oxygen delivery-utilization mismatch in contracting locomotor muscle in COPD : peripheral factors .
25879126	0	Oxygen	10,16	COPD	36,40	Oxygen	COPD	MESH:D010100	260431	Chemical	Gene	Therapy|compound|START_ENTITY Therapy|nmod|Oxygen Oxygen|compound|END_ENTITY	Long-Term Oxygen Therapy for Severe COPD Oxygen is an essential component of oxidative metabolism and is used as a treatment in patients with chronic_lung_disease .
25879126	0	Oxygen	10,16	COPD	36,40	Oxygen	COPD	MESH:D010100	260431	Chemical	Gene	Therapy|compound|START_ENTITY Therapy|nmod|Oxygen Oxygen|compound|END_ENTITY	Long-Term Oxygen Therapy for Severe COPD Oxygen is an essential component of oxidative metabolism and is used as a treatment in patients with chronic_lung_disease .
26867829	0	Oxygen	28,34	COPD	112,116	Oxygen	COPD	MESH:D010100	260431	Chemical	Gene	Expose|nsubj|START_ENTITY Expose|nmod|END_ENTITY	COUNTERPOINT : Does Low-Dose Oxygen Expose Patients With COPD to More Radiation-Like Risks Than Patients Without COPD ?
26867829	0	Oxygen	28,34	COPD	56,60	Oxygen	COPD	MESH:D010100	260431	Chemical	Gene	Expose|nsubj|START_ENTITY Expose|dobj|Patients Patients|nmod|END_ENTITY	COUNTERPOINT : Does Low-Dose Oxygen Expose Patients With COPD to More Radiation-Like Risks Than Patients Without COPD ?
27076586	0	Oxygen	0,6	COPD	80,84	Oxygen	COPD	MESH:D010100	260431	Chemical	Gene	desaturation|compound|START_ENTITY factor|nsubj|desaturation factor|nmod|outcomes outcomes|nmod|END_ENTITY	Oxygen desaturation in 6-min walk test is a risk factor for adverse outcomes in COPD .
26934203	0	Oxygen	48,54	Catalase	0,8	Oxygen	Catalase	MESH:D010100	847	Chemical	Gene	Electrodes|dep|START_ENTITY Electrodes|compound|END_ENTITY	Catalase Modified Carbon Electrodes : Persuading Oxygen to Accept Four Electrons Rather Than Two .
26157141	0	Oxygen	80,86	Claudin-1	46,55	Oxygen	Claudin-1	MESH:D010100	9076	Chemical	Gene	Activation|compound|START_ENTITY Expression|nmod|Activation Expression|compound|END_ENTITY	Mitochondrial Respiratory Dysfunction Induces Claudin-1 Expression via Reactive Oxygen Species-mediated Heat_Shock_Factor_1 Activation , Leading to Hepatoma Cell Invasiveness .
26561980	0	Oxygen	96,102	Endothelin-1	0,12	Oxygen	Endothelin-1	MESH:D010100	13614(Tax:10090)	Chemical	Gene	Species|compound|START_ENTITY Sickle_Cell_Disease|nmod|Species Contributes|nmod|Sickle_Cell_Disease Contributes|compound|END_ENTITY	Endothelin-1 Contributes to the Progression of Renal_Injury in Sickle_Cell_Disease via Reactive Oxygen Species .
10535739	0	Oxygen	0,6	FGF	78,81	Oxygen	FGF	MESH:D010100	42356(Tax:7227)	Chemical	Gene	regulation|compound|START_ENTITY mediated|nsubjpass|regulation mediated|nmod|END_ENTITY	Oxygen regulation of airway branching in Drosophila is mediated by branchless FGF .
26782237	0	Oxygen	26,32	Flap	21,25	Oxygen	Flap	MESH:D010100	241	Chemical	Gene	Saturation|compound|START_ENTITY Saturation|compound|END_ENTITY	Local Measurement of Flap Oxygen Saturation : An Application of Visible Light Spectroscopy .
23008742	0	Oxygen	109,115	Focal_Adhesion_Kinase	146,167	Oxygen	Focal Adhesion Kinase	MESH:D010100	14083(Tax:10090)	Chemical	Gene	Species|compound|START_ENTITY Anoikis|nmod|Species Anoikis|nmod|END_ENTITY	Polygonum cuspidatum Extract Induces Anoikis in Hepatocarcinoma Cells Associated with Generation of Reactive Oxygen Species and Downregulation of Focal_Adhesion_Kinase .
19536482	0	Oxygen	0,6	HIF-1	69,74	Oxygen	HIF-1	MESH:D010100	3091	Chemical	Gene	sensing|compound|START_ENTITY inducible|nsubj|sensing inducible|dobj|factor factor|appos|END_ENTITY	Oxygen sensing and the activation of the hypoxia inducible factor 1 -LRB- HIF-1 -RRB- -- invited article .
22946054	0	Oxygen	0,6	HIF-1	124,129	Oxygen	HIF-1	MESH:D010100	3091	Chemical	Gene	START_ENTITY|acl|sensing sensing|nmod|signalling signalling|compound|END_ENTITY	Oxygen sensing by the prolyl-4-hydroxylase PHD2 within the nuclear compartment and the influence of compartmentalisation on HIF-1 signalling .
23091723	0	Oxygen	0,6	HIF-1a	51,57	Oxygen	HIF-1a	MESH:D010100	3091	Chemical	Gene	Oxygen|compound|START_ENTITY Oxygen|nmod|Regulation Regulation|nmod|END_ENTITY	Oxygen versus Reactive Oxygen in the Regulation of HIF-1a : The Balance Tips .
23091723	0	Oxygen	23,29	HIF-1a	51,57	Oxygen	HIF-1a	MESH:D010100	3091	Chemical	Gene	START_ENTITY|nmod|Regulation Regulation|nmod|END_ENTITY	Oxygen versus Reactive Oxygen in the Regulation of HIF-1a : The Balance Tips .
25317019	0	Oxygen	104,110	HIF-1a	37,43	Oxygen	HIF-1a	MESH:D010100	3091	Chemical	Gene	Content|compound|START_ENTITY Transcription|nmod|Content Transcription|nmod|END_ENTITY	Bilirubin_Activates Transcription of HIF-1a in Human Proximal Tubular Cells Cultured in the Physiologic Oxygen Content .
15848121	0	Oxygen	0,6	HIF-1alpha	62,72	Oxygen	HIF-1alpha	MESH:D010100	29560(Tax:10116)	Chemical	Gene	span|compound|START_ENTITY span|dep|hypoxia hypoxia|nmod|model model|acl|studying studying|dobj|END_ENTITY	Oxygen and life span : chronic hypoxia as a model for studying HIF-1alpha , VEGF and NOS during aging .
16728520	0	Oxygen	0,6	HIF-1alpha	95,105	Oxygen	HIF-1alpha	MESH:D010100	29560(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY alters|nsubj|treatment alters|dobj|expression expression|nmod|END_ENTITY	Oxygen treatment after experimental hypoxia-ischemia in neonatal rats alters the expression of HIF-1alpha and its downstream target genes .
26157141	0	Oxygen	80,86	Heat_Shock_Factor_1	104,123	Oxygen	Heat Shock Factor 1	MESH:D010100	3297	Chemical	Gene	Activation|compound|START_ENTITY Activation|compound|END_ENTITY	Mitochondrial Respiratory Dysfunction Induces Claudin-1 Expression via Reactive Oxygen Species-mediated Heat_Shock_Factor_1 Activation , Leading to Hepatoma Cell Invasiveness .
20486760	0	Oxygen	9,15	Heme_Oxygenase-1	82,98	Oxygen	Heme Oxygenase-1	MESH:D010100	24451(Tax:10116)	Chemical	Gene	c-Fos/Activator|compound|START_ENTITY _|nsubj|c-Fos/Activator _|dobj|Expression Expression|compound|END_ENTITY	Reactive Oxygen Species-Dependent c-Fos/Activator _ Protein_1 Induction Upregulates Heme_Oxygenase-1 Expression by Bradykinin in Brain Astrocytes .
25661467	0	Oxygen	169,175	Heme_Oxygenase-1	139,155	Oxygen	Heme Oxygenase-1	MESH:D010100	3162	Chemical	Gene	Species|compound|START_ENTITY END_ENTITY|nmod|Species	High Glucose Promotes Tumor Invasion and Increases Metastasis-Associated_Protein Expression in Human Lung Epithelial Cells by Upregulating Heme_Oxygenase-1 via Reactive Oxygen Species or the TGF-b1 / PI3K/Akt Signaling Pathway .
25604781	0	Oxygen	11,17	Heme_Oxygenase_1	108,124	Oxygen	Heme Oxygenase 1	MESH:D010100	15368(Tax:10090)	Chemical	Gene	Injury|compound|START_ENTITY Injury|dep|Upregulation Upregulation|nmod|Expression Expression|compound|END_ENTITY	Hyperbaric Oxygen Preconditioning Attenuates Myocardium Ischemia-Reperfusion Injury Through Upregulation of Heme_Oxygenase_1 Expression : PI3K/Akt/Nrf2 Pathway Involved .
25338163	0	Oxygen	76,82	HiF-1a	32,38	Oxygen	HiF-1a	MESH:D010100	3091	Chemical	Gene	Conditions|compound|START_ENTITY Dynamics|nmod|Conditions Dynamics|compound|END_ENTITY	Role of Compartmentalization on HiF-1a Degradation Dynamics during Changing Oxygen Conditions : A Computational Approach .
25214643	0	Oxygen	145,151	Hypoxia-Inducible_Factor-1a	74,101	Oxygen	Hypoxia-Inducible Factor-1a	MESH:D010100	3091	Chemical	Gene	Generation|compound|START_ENTITY Uptake|dep|Generation Uptake|nmod|Activation Activation|compound|END_ENTITY	Oxidized Low-Density Lipoprotein Stimulates Macrophage 18F-FDG Uptake via Hypoxia-Inducible_Factor-1a Activation Through Nox2-Dependent Reactive Oxygen Species Generation .
25546605	0	Oxygen	54,60	Hypoxia-Inducible_Factor-1a	14,41	Oxygen	Hypoxia-Inducible Factor-1a	MESH:D010100	3091	Chemical	Gene	Species|compound|START_ENTITY END_ENTITY|nmod|Species	Regulation of Hypoxia-Inducible_Factor-1a by Reactive Oxygen Species : New Developments in an Old Debate .
12748425	0	Oxygen	0,6	ICAM-1	24,30	Oxygen	ICAM-1	MESH:D010100	25464(Tax:10116)	Chemical	Gene	radicals|compound|START_ENTITY promote|nsubj|radicals promote|dobj|expression expression|compound|END_ENTITY	Oxygen radicals promote ICAM-1 expression and microcirculatory disturbances in experimental acute pancreatitis .
26152715	0	Oxygen	46,52	IL-10	169,174	Oxygen	IL-10	MESH:D010100	3586	Chemical	Gene	Species|compound|START_ENTITY Production|nmod|Species Inhibits|dep|Production Inhibits|dep|Oxidoreductase Oxidoreductase|nmod|Induction Induction|nmod|Interleukin-1b Interleukin-1b|appos|END_ENTITY	Metformin Inhibits the Production of Reactive Oxygen Species from NADH : Ubiquinone Oxidoreductase to Limit Induction of Interleukin-1b -LRB- IL-1b -RRB- and Boosts Interleukin-10 -LRB- IL-10 -RRB- in Lipopolysaccharide -LRB- LPS -RRB- - activated Macrophages .
25159478	0	Oxygen	127,133	IL-1b	0,5	Oxygen	IL-1b	MESH:D010100	24494(Tax:10116)	Chemical	Gene	Signals|compound|START_ENTITY Transactivation|nmod|Signals Migration|nmod|Transactivation MMP-9-Dependent|dobj|Migration MMP-9-Dependent|nsubj|Induces Induces|compound|END_ENTITY	IL-1b Induces MMP-9-Dependent Brain Astrocytic Migration via Transactivation of PDGF Receptor/NADPH _ Oxidase_2-Derived Reactive Oxygen Species Signals .
26152715	0	Oxygen	46,52	IL-1b	135,140	Oxygen	IL-1b	MESH:D010100	3553	Chemical	Gene	Species|compound|START_ENTITY Production|nmod|Species Inhibits|dep|Production Inhibits|dep|Oxidoreductase Oxidoreductase|nmod|Induction Induction|nmod|Interleukin-1b Interleukin-1b|appos|END_ENTITY	Metformin Inhibits the Production of Reactive Oxygen Species from NADH : Ubiquinone Oxidoreductase to Limit Induction of Interleukin-1b -LRB- IL-1b -RRB- and Boosts Interleukin-10 -LRB- IL-10 -RRB- in Lipopolysaccharide -LRB- LPS -RRB- - activated Macrophages .
26290366	0	Oxygen	16,22	IL-1b	58,63	Oxygen	IL-1b	MESH:D010100	24494(Tax:10116)	Chemical	Gene	Species|compound|START_ENTITY dependent|nsubj|Species dependent|dobj|effects effects|nmod|END_ENTITY	Acute , Reactive Oxygen Species -LRB- ROS -RRB- dependent effects of IL-1b , TNF-a , and IL-6 on the glomerular filtration barrier -LRB- GFB -RRB- in vivo .
26290366	0	Oxygen	16,22	IL-1b	58,63	Oxygen	IL-1b	MESH:D010100	24494(Tax:10116)	Chemical	Gene	Species|compound|START_ENTITY dependent|nsubj|Species dependent|dobj|effects effects|nmod|END_ENTITY	Acute , Reactive Oxygen Species -LRB- ROS -RRB- dependent effects of IL-1b , TNF-a , and IL-6 on the glomerular filtration barrier -LRB- GFB -RRB- in vivo .
25178491	0	Oxygen	94,100	JNK	118,121	Oxygen	JNK	MESH:D010100	5599	Chemical	Gene	Activation|compound|START_ENTITY Activation|compound|END_ENTITY	2 - -LRB- Pro-1-ynyl -RRB- -5 - -LRB- 5,6-dihydroxypenta-1 ,3 - diynyl -RRB- Thiophene Induces Apoptosis Through Reactive Oxygen Species-Mediated JNK Activation in Human Colon Cancer SW620 Cells .
26037477	0	Oxygen	45,51	Jumonji_Domain_Containing_Protein_6	0,35	Oxygen	Jumonji Domain Containing Protein 6	MESH:D010100	23210	Chemical	Gene	Sensor|compound|START_ENTITY END_ENTITY|dep|Sensor	Jumonji_Domain_Containing_Protein_6 : A Novel Oxygen Sensor in the Human Placenta .
11390925	0	Oxygen	19,25	Myoglobin	0,9	Oxygen	Myoglobin	MESH:D010100	4151	Chemical	Gene	Store|compound|START_ENTITY END_ENTITY|dep|Store	Myoglobin : Just an Oxygen Store or Also an Oxygen Transporter ?
26682003	0	Oxygen	100,106	Nrf2	17,21	Oxygen	Nrf2	MESH:D010100	4780	Chemical	Gene	Species|compound|START_ENTITY Relevance|nmod|Species Relevance|nmod|Pathway Pathway|compound|END_ENTITY	The Relevance of Nrf2 Pathway and Autophagy in Pancreatic_Cancer Cells upon Stimulation of Reactive Oxygen Species .
1155335	0	Oxygen	0,6	P50	67,70	Oxygen	P50	MESH:D010100	4790	Chemical	Gene	delivery|compound|START_ENTITY delivery|appos|END_ENTITY	Oxygen delivery , anoxic metabolism and hemoglobin-oxygen affinity -LRB- P50 -RRB- in patients with acute_myocardial_infarction and shock .
6701046	0	Oxygen	0,6	P50	81,84	Oxygen	P50	MESH:D010100	4790	Chemical	Gene	transport|compound|START_ENTITY transport|dep|effects effects|nmod|END_ENTITY	Oxygen transport in the intact_hypoxic_newborn_lamb : acute effects of increasing P50 .
26774962	0	Oxygen	30,36	PHD1	44,48	Oxygen	PHD1	MESH:D010100	112406(Tax:10090)	Chemical	Gene	Protects|compound|START_ENTITY Protects|compound|END_ENTITY	Deletion or Inhibition of the Oxygen Sensor PHD1 Protects against Ischemic_Stroke_via_Reprogramming_of_Neuronal_Metabolism .
25995437	0	Oxygen	31,37	Pyruvate_Dehydrogenase	53,75	Oxygen	Pyruvate Dehydrogenase	MESH:D010100	54704	Chemical	Gene	Metabolism|compound|START_ENTITY Metabolism|nmod|END_ENTITY	The PI3K/Akt Pathway Regulates Oxygen Metabolism via Pyruvate_Dehydrogenase -LRB- PDH -RRB- - E1a Phosphorylation .
25995437	0	Oxygen	31,37	Pyruvate_Dehydrogenase	53,75	Oxygen	Pyruvate Dehydrogenase	MESH:D010100	54704	Chemical	Gene	Metabolism|compound|START_ENTITY Metabolism|nmod|END_ENTITY	The PI3K/Akt Pathway Regulates Oxygen Metabolism via Pyruvate_Dehydrogenase -LRB- PDH -RRB- - E1a Phosphorylation .
16665795	0	Oxygen	81,87	Superoxide_Dismutase	0,20	Oxygen	Superoxide Dismutase	MESH:D010100	6647	Chemical	Gene	Deprivation|compound|START_ENTITY Recovery|nmod|Deprivation Factor|nmod|Recovery END_ENTITY|dep|Factor	Superoxide_Dismutase as an Anaerobic Polypeptide : A Key Factor in Recovery from Oxygen Deprivation in Iris pseudacorus ?
25132966	0	Oxygen	88,94	Superoxide_Dismutase	15,35	Oxygen	Superoxide Dismutase	MESH:D010100	6647	Chemical	Gene	Species|compound|START_ENTITY Accumulation|nmod|Species Surfaces|nmod|Accumulation Surfaces|nsubj|Development Development|nmod|Mimetic Mimetic|compound|END_ENTITY	Development of Superoxide_Dismutase Mimetic Surfaces to Reduce Accumulation of Reactive Oxygen Species for Neural Interfacing Applications .
25132966	0	Oxygen	88,94	Superoxide_Dismutase	15,35	Oxygen	Superoxide Dismutase	MESH:D010100	6647	Chemical	Gene	Species|compound|START_ENTITY Accumulation|nmod|Species Surfaces|nmod|Accumulation Surfaces|nsubj|Development Development|nmod|Mimetic Mimetic|compound|END_ENTITY	Development of Superoxide_Dismutase Mimetic Surfaces to Reduce Accumulation of Reactive Oxygen Species for Neural Interfacing Applications .
7833842	0	Oxygen	0,6	TGF-beta_1	21,31	Oxygen	TGF-beta 1	MESH:D010100	7040	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|mRNA mRNA|compound|END_ENTITY	Oxygen regulation of TGF-beta_1 mRNA in human hepatoma -LRB- Hep G2 -RRB- cells .
10889449	0	Oxygen	0,6	TNF-alpha	96,105	Oxygen	TNF-alpha	MESH:D010100	7124	Chemical	Gene	radicals|amod|START_ENTITY mediate|nsubj|radicals mediate|nmod|END_ENTITY	Oxygen free radicals mediate the induction of manganese_superoxide dismutase gene expression by TNF-alpha .
26111475	0	Oxygen	60,66	TRAIL	130,135	Oxygen	TRAIL	MESH:D010100	8743	Chemical	Gene	Sensitization|compound|START_ENTITY Sensitization|nmod|Cells Cells|nmod|Apoptosis Apoptosis|compound|END_ENTITY	Upregulation of Death_Receptor_5 and Production of Reactive Oxygen Species Mediate Sensitization of PC-3 Prostate_Cancer Cells to TRAIL Induced Apoptosis by Vitisin_A .
25012594	0	Oxygen	60,66	Toll-Like_Receptor_4	118,138	Oxygen	Toll-Like Receptor 4	MESH:D010100	7099	Chemical	Gene	Deprivation|nmod|START_ENTITY Caused|nmod|Deprivation Caused|nmod|Regulation Regulation|nmod|Pathway Pathway|compound|END_ENTITY	Isoflurane Protects Against Injury Caused by Deprivation of Oxygen and Glucose in Microglia Through Regulation of the Toll-Like_Receptor_4 Pathway .
16115043	0	Oxygen	0,6	VEGF	38,42	Oxygen	VEGF	MESH:D010100	7422	Chemical	Gene	START_ENTITY|dep|benefits benefits|acl|inducing inducing|dobj|expression expression|amod|END_ENTITY	Oxygen : from the benefits of inducing VEGF expression to managing the risk of hyperbaric stress .
25893364	0	Oxygen	54,60	VEGF	93,97	Oxygen	VEGF	MESH:D010100	395909(Tax:9031)	Chemical	Gene	Species|compound|START_ENTITY Species|appos|END_ENTITY	Tungsten_Carbide-Cobalt Nanoparticles Induce Reactive Oxygen Species , AKT , ERK , AP-1 , NF-kB , VEGF , and Angiogenesis .
26608360	0	Oxygen	127,133	Vascular_Cell_Adhesion_Molecule-1	41,74	Oxygen	Vascular Cell Adhesion Molecule-1	MESH:D010100	7412	Chemical	Gene	Species|compound|START_ENTITY Expression|nmod|Species Expression|compound|END_ENTITY	The 18-kDa Translocator Protein Inhibits Vascular_Cell_Adhesion_Molecule-1 Expression via Inhibition of Mitochondrial Reactive Oxygen Species .
26986047	0	Oxygen	43,49	WST11	74,79	Oxygen	WST11	MESH:D010100	3371119(Tax:273121)	Chemical	Gene	Generation|compound|START_ENTITY Generation|nmod|END_ENTITY	Nonthermal Ablation by Using Intravascular Oxygen Radical Generation with WST11 : Dynamic Tissue Effects and Implications for Focal Therapy .
8080278	0	Oxygen	0,6	alkaline_phosphatase	37,57	Oxygen	alkaline phosphatase	MESH:D010100	250	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|activity activity|amod|END_ENTITY	Oxygen radical-induced inhibition of alkaline_phosphatase activity in reconstituted membranes .
8897957	0	Oxygen	0,6	alpha_1B-adrenergic_receptor	17,45	Oxygen	alpha 1B-adrenergic receptor	MESH:D010100	147	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	Oxygen modulates alpha_1B-adrenergic_receptor gene expression by arterial but not venous vascular smooth muscle .
7789421	0	Oxygen	0,6	bFGF	31,35	Oxygen	bFGF	MESH:D010100	2247	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|production production|nmod|END_ENTITY	Oxygen modulates production of bFGF and TGF-beta by retinal cells in vitro .
20690091	0	Oxygen	0,6	brain_natriuretic_peptide	47,72	Oxygen	brain natriuretic peptide	MESH:D010100	4879	Chemical	Gene	uptake|nsubj|START_ENTITY uptake|nmod|END_ENTITY	Oxygen uptake efficiency slope correlates with brain_natriuretic_peptide in patients with heart_failure .
9555909	0	Oxygen	0,6	ccoN	25,29	Oxygen	ccoN	MESH:D010100	3718174(Tax:272943)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|gene gene|compound|END_ENTITY	Oxygen regulation of the ccoN gene encoding a component of the cbb3 oxidase in Rhodobacter_sphaeroides_2 .4.1 T : involvement of the FnrL protein .
9021387	0	Oxygen	0,6	endothelin-1	31,43	Oxygen	endothelin-1	MESH:D010100	1906	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Oxygen promotes contraction by endothelin-1 in human umbilical artery .
17493766	0	Oxygen	0,6	erythropoietin	69,83	Oxygen	erythropoietin	MESH:D010100	2056	Chemical	Gene	breathing|compound|START_ENTITY alternative|nsubj|breathing alternative|nmod|END_ENTITY	Oxygen breathing may be a cheaper and safer alternative to exogenous erythropoietin -LRB- EPO -RRB- .
9747510	0	Oxygen	0,6	heme_oxygenase-1	25,41	Oxygen	heme oxygenase-1	MESH:D010100	3162	Chemical	Gene	tension|compound|START_ENTITY regulates|nsubj|tension regulates|dobj|expression expression|amod|END_ENTITY	Oxygen tension regulates heme_oxygenase-1 gene expression in mammalian cell lines .
9510527	0	Oxygen	0,6	hypoxia-inducible_factor-1	16,42	Oxygen	hypoxia-inducible factor-1	MESH:D010100	3091	Chemical	Gene	sensing|compound|START_ENTITY sensing|appos|regulation regulation|amod|END_ENTITY	Oxygen sensing , hypoxia-inducible_factor-1 and the regulation of mammalian gene expression .
12888568	0	Oxygen	0,6	iron_regulatory_protein_2	30,55	Oxygen	iron regulatory protein 2	MESH:D010100	3658	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Oxygen and iron regulation of iron_regulatory_protein_2 .
16940473	0	Oxygen	0,6	macrophage_migration_inhibitory_factor	21,59	Oxygen	macrophage migration inhibitory factor	MESH:D010100	4282	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Oxygen regulation of macrophage_migration_inhibitory_factor in human placenta .
15039463	0	Oxygen	0,6	myeloperoxidase	64,79	Oxygen	myeloperoxidase	MESH:D010100	4353	Chemical	Gene	dysfunction|compound|START_ENTITY dysfunction|dep|role role|nmod|END_ENTITY	Oxygen radical-induced natural killer cell dysfunction : role of myeloperoxidase and regulation by serotonin .
12656610	0	Oxygen	0,6	myoglobin	33,42	Oxygen	myoglobin	MESH:D010100	102975021	Chemical	Gene	properties|amod|START_ENTITY properties|nmod|END_ENTITY	Oxygen equilibrium properties of myoglobin locked in the liganded and unliganded conformations .
15817640	0	Oxygen	0,6	myoglobin	45,54	Oxygen	myoglobin	MESH:D010100	17189(Tax:10090)	Chemical	Gene	supply|compound|START_ENTITY supply|acl|scavenging scavenging|nmod|END_ENTITY	Oxygen supply and nitric_oxide scavenging by myoglobin contribute to exercise endurance and cardiac function .
4003568	0	Oxygen	0,6	myoglobin	71,80	Oxygen	myoglobin	MESH:D010100	608715(Tax:9615)	Chemical	Gene	transport|compound|START_ENTITY illustrates|nsubj|transport illustrates|dobj|functions functions|nmod|END_ENTITY	Oxygen transport in rest-work transition illustrates new functions for myoglobin .
24096875	0	Oxygen	46,52	p53	0,3	Oxygen	p53	MESH:D010100	7157	Chemical	Gene	protects|nsubj|START_ENTITY choice|parataxis|protects choice|nsubj|END_ENTITY	p53 's choice of myocardial_death or survival : Oxygen protects infarct_myocardium by recruiting p53 on NOS3 promoter through regulation of p53-Lys -LRB- 118 -RRB- acetylation .
24096875	0	Oxygen	46,52	p53	95,98	Oxygen	p53	MESH:D010100	7157	Chemical	Gene	protects|nsubj|START_ENTITY protects|advcl|recruiting recruiting|dobj|END_ENTITY	p53 's choice of myocardial_death or survival : Oxygen protects infarct_myocardium by recruiting p53 on NOS3 promoter through regulation of p53-Lys -LRB- 118 -RRB- acetylation .
20146936	0	Oxygen	0,6	superoxide_dismutase	35,55	Oxygen	superoxide dismutase	MESH:D010100	6647	Chemical	Gene	tolerance|compound|START_ENTITY tolerance|nmod|END_ENTITY	Oxygen tolerance and occurrence of superoxide_dismutase as an antioxidant enzyme in Metopus es .
17293486	0	Oxygen	0,6	thioredoxin	48,59	Oxygen	thioredoxin	MESH:D010100	7295	Chemical	Gene	sensing|compound|START_ENTITY sensing|dep|role role|nmod|END_ENTITY	Oxygen sensing and redox signaling : the role of thioredoxin in embryonic development and cardiac_diseases .
8221780	0	Oxygen	0,6	tissue_plasminogen_activator	58,86	Oxygen	tissue plasminogen activator	MESH:D010100	100128998	Chemical	Gene	agents|compound|START_ENTITY agents|nmod|therapy therapy|nmod|END_ENTITY	Oxygen radical scavenging agents as adjuvant therapy with tissue_plasminogen_activator in a canine model of coronary thrombolysis .
17520326	0	Oxygen	0,6	tyrosine_hydroxylase	21,41	Oxygen	tyrosine hydroxylase	MESH:D010100	7054	Chemical	Gene	dependence|compound|START_ENTITY dependence|nmod|END_ENTITY	Oxygen dependence of tyrosine_hydroxylase .
22044301	0	Oxygen	0,6	vascular_endothelial_growth_factor	76,110	Oxygen	vascular endothelial growth factor	MESH:D010100	7422	Chemical	Gene	START_ENTITY|dep|effect effect|nmod|cobalt_chloride cobalt_chloride|nmod|production production|compound|END_ENTITY	Oxygen as a regulator of MA-10 cell functions : effect of cobalt_chloride on vascular_endothelial_growth_factor production .
25237906	0	Oxygen-Glucose	41,55	Connexin32	76,86	Oxygen-Glucose	Connexin32	null	2705	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Tetramethylpyrazine Suppresses Transient Oxygen-Glucose Deprivation-Induced Connexin32 Expression and Cell Apoptosis via the ERK1/2 and p38 MAPK Pathway in Cultured Hippocampal Neurons .
25237906	0	Oxygen-Glucose	41,55	ERK1/2	125,131	Oxygen-Glucose	ERK1/2	null	5595;5594	Chemical	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	Tetramethylpyrazine Suppresses Transient Oxygen-Glucose Deprivation-Induced Connexin32 Expression and Cell Apoptosis via the ERK1/2 and p38 MAPK Pathway in Cultured Hippocampal Neurons .
1874284	0	Oxyhaemoglobin	0,14	endothelin-1	43,55	Oxyhaemoglobin	endothelin-1	CHEBI:7861	281137(Tax:9913)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|production production|nmod|END_ENTITY	Oxyhaemoglobin increases the production of endothelin-1 by endothelial cells in culture .
24703579	0	Oxylipins	0,9	TNF-a	105,110	Oxylipins	TNF-a	MESH:D054883	7124	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Oxylipins from the microalgae Chlamydomonas debaryana and Nannochloropsis gaditana and their activity as TNF-a inhibitors .
25527205	0	Oxymatrine	0,10	EGFR	19,23	Oxymatrine	EGFR	MESH:C037573	1956	Chemical	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Oxymatrine targets EGFR -LRB- p-Tyr845 -RRB- and inhibits EGFR-related signaling pathways to suppress the proliferation and invasion of gastric_cancer cells .
20182634	0	Oxymatrine	0,10	TLR4	25,29	Oxymatrine	TLR4	MESH:C037573	29260(Tax:10116)	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	Oxymatrine downregulates TLR4 , TLR2 , MyD88 , and NF-kappaB and protects rat brains against focal ischemia .
25406654	0	Oxymatrine	38,48	Toll-Like_Receptor_9	52,72	Oxymatrine	Toll-Like Receptor 9	MESH:C037573	54106	Chemical	Gene	START_ENTITY|nmod|Pathway Pathway|compound|END_ENTITY	In vitro Immunomodulatory Activity of Oxymatrine on Toll-Like_Receptor_9 Signal Pathway in Chronic_Hepatitis_B .
21190123	0	Oxymatrine	0,10	Toll-like_receptor_4	57,77	Oxymatrine	Toll-like receptor 4	MESH:C037573	29260(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|advcl|inhibiting inhibiting|dobj|responses responses|amod|/ /|amod|END_ENTITY	Oxymatrine reduces neuronal cell apoptosis by inhibiting Toll-like_receptor_4 / nuclear_factor_kappa-B-dependent inflammatory responses in traumatic rat brain_injury .
25668061	0	Oxymatrine	0,10	Toll-like_receptor_4	79,99	Oxymatrine	Toll-like receptor 4	MESH:C037573	21898(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Oxymatrine inhibits lipopolysaccharide-induced inflammation by down-regulating Toll-like_receptor_4 / nuclear factor-kappa B in macrophages .
22819197	0	Oxysterol	0,9	AKT	21,24	Oxysterol	AKT	CHEBI:53030	207	Chemical	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Oxysterol receptors , AKT and prostate_cancer .
15322366	0	Oxysterol	0,9	estrogen_receptor	24,41	Oxysterol	estrogen receptor	CHEBI:53030	2099	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Oxysterol regulation of estrogen_receptor alpha-mediated gene expression in a transcriptional activation assay system using HeLa cells .
9804848	0	Oxysterol	0,9	steroidogenic_acute_regulatory_protein	24,62	Oxysterol	steroidogenic acute regulatory protein	CHEBI:53030	6770	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Oxysterol regulation of steroidogenic_acute_regulatory_protein gene expression .
14999691	0	Oxysterols	0,10	cyclooxygenase-2	18,34	Oxysterols	cyclooxygenase-2	CHEBI:53030	5743	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|amod|END_ENTITY	Oxysterols induce cyclooxygenase-2 expression in cholangiocytes : implications for biliary tract carcinogenesis .
26338335	0	Oxytocin	0,8	Crf	34,37	Oxytocin	Crf	MESH:D010121	1392	Chemical	Gene	Transcription|compound|START_ENTITY Transcription|compound|END_ENTITY	Oxytocin Regulates Stress-Induced Crf Gene Transcription through CREB-Regulated_Transcription_Coactivator_3 .
27052180	0	Oxytocin	75,83	KCC2	97,101	Oxytocin	KCC2	MESH:D010121	57138(Tax:10090)	Chemical	Gene	Receptor|compound|START_ENTITY Receptor|nmod|END_ENTITY	The Timing of the Excitatory-to-Inhibitory GABA Switch Is Regulated by the Oxytocin Receptor via KCC2 .
23838880	0	Oxytocin	0,8	OXTR	24,28	Oxytocin	OXTR	MESH:D010121	5021	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Oxytocin receptor gene -LRB- OXTR -RRB- in relation to loneliness in adolescence : interactions with sex , parental support , and DRD2 and 5-HTTLPR genotypes .
26442453	0	Oxytocin	69,77	Oxtr	14,18	Oxytocin	Oxtr	MESH:D010121	18430(Tax:10090)	Chemical	Gene	Manner|compound|START_ENTITY Expression|nmod|Manner Mice|nmod|Expression Generation|dep|Mice Generation|nmod|cDNA cDNA|compound|END_ENTITY	Generation of Oxtr cDNA -LRB- HA -RRB- - Ires-Cre Mice for Gene Expression in an Oxytocin Receptor Specific Manner .
24644013	0	Oxytocin	0,8	aquaporin_5	37,48	Oxytocin	aquaporin 5	MESH:D010121	25241(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Oxytocin regulates the expression of aquaporin_5 in the late-pregnant rat uterus .
25573626	0	Oxytocin	6,14	c-Fos	105,110	Oxytocin	c-Fos	MESH:D010121	14281(Tax:10090)	Chemical	Gene	Intake|compound|START_ENTITY Intake|nmod|Induction Induction|amod|END_ENTITY	Nasal Oxytocin Administration Reduces Food Intake without Affecting Locomotor Activity and Glycemia with c-Fos Induction in Limited Brain Areas .
15044536	0	Oxytocin	0,8	c-fos	35,40	Oxytocin	c-fos	MESH:D010121	2353	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|amod|END_ENTITY	Oxytocin attenuates stress-induced c-fos mRNA expression in specific forebrain regions associated with modulation of hypothalamo-pituitary-adrenal activity .
2126973	0	Oxytocin	0,8	c-fos	49,54	Oxytocin	c-fos	MESH:D010121	314322(Tax:10116)	Chemical	Gene	neurons|compound|START_ENTITY hypothalamus|nsubj|neurons hypothalamus|dobj|END_ENTITY	Oxytocin neurons in the rat hypothalamus exhibit c-fos immunoreactivity upon osmotic stress .
12118334	0	Oxytocin	0,8	estrogen_receptor_alpha	19,42	Oxytocin	estrogen receptor alpha	MESH:D010121	2099	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|compound|END_ENTITY	Oxytocin modulates estrogen_receptor_alpha expression and function in MCF7 human breast_cancer cells .
9122267	0	Oxytocin	0,8	luteinizing_hormone-releasing_hormone	35,72	Oxytocin	luteinizing hormone-releasing hormone	MESH:D010121	25194(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|nmod|END_ENTITY	Oxytocin stimulates the release of luteinizing_hormone-releasing_hormone from medial basal hypothalamic explants by releasing nitric_oxide .
9112404	0	Oxytocin	0,8	phosphoinositidase_C	41,61	Oxytocin	phosphoinositidase C	MESH:D010121	23236	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Oxytocin receptor-mediated activation of phosphoinositidase_C and elevation of cytosolic calcium in the gonadotrope-derived alphaT3-1 cell line .
11171655	0	Oxytocin	0,8	renin	48,53	Oxytocin	renin	MESH:D010121	24715(Tax:10116)	Chemical	Gene	antagonist|compound|START_ENTITY disrupts|nsubj|antagonist disrupts|dobj|secretion secretion|compound|END_ENTITY	Oxytocin antagonist disrupts hypotension-evoked renin secretion and other responses in conscious rats .
9757887	0	Oxytocin	0,8	vasoactive_intestinal_polypeptide	44,77	Oxytocin	vasoactive intestinal polypeptide	MESH:D010121	7432	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|xcomp|END_ENTITY	Oxytocin enhances the prolactin response to vasoactive_intestinal_polypeptide in healthy women .
26990079	0	Ozanimod	0,8	sphingosine-1-phosphate_receptor-1	31,65	Ozanimod	sphingosine-1-phosphate receptor-1	null	1901	Chemical	Gene	agonist|nsubj|START_ENTITY agonist|amod|END_ENTITY	Ozanimod -LRB- RPC1063 -RRB- is a potent sphingosine-1-phosphate_receptor-1 -LRB- S1P1R -RRB- and receptor-5 -LRB- S1P5R -RRB- agonist with autoimmune_disease-modifying activity .
5447535	0	Ozone	0,5	bean	16,20	Ozone	bean	MESH:D010126	146227	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|END_ENTITY	Ozone uptake by bean leaves .
21782706	0	Ozone	0,5	iNOS	23,27	Ozone	iNOS	MESH:D010126	24599(Tax:10116)	Chemical	Gene	exposure|compound|START_ENTITY induces|nsubj|exposure induces|dobj|expression expression|amod|END_ENTITY	Ozone exposure induces iNOS expression and tyrosine nitration in rat aorta .
2820951	0	P-4504	28,34	Cytochrome_P-450	0,16	P-4504	Cytochrome P-450	null	100328948(Tax:9986)	Chemical	Gene	related|nmod|START_ENTITY related|nsubj|END_ENTITY	Cytochrome_P-450 related to P-4504 from phenobarbital-treated rabbit liver : molecular cloning of cDNA and characterization of cytochrome_P-450 obtained by its expression in yeast cells .
4022004	0	P-enolpyruvate	43,57	prolactin	10,19	P-enolpyruvate	prolactin	null	24683(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY Effect|nmod|activity Effect|nmod|END_ENTITY	Effect of prolactin and glucocorticoids on P-enolpyruvate carboxykinase activity in liver and mammary gland from diabetic and lactating rats .
12533606	0	P118-135	77,85	PrP	103,106	P118-135	PrP	null	5621	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	In vivo and in vitro neurotoxicity of the human prion_protein -LRB- PrP -RRB- fragment P118-135 independently of PrP expression .
24685639	0	P165	32,36	MMP-1	87,92	P165	MMP-1	null	4312	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	N-terminal 5-mer peptide analog P165 of amyloid precursor protein inhibits UVA-induced MMP-1 expression by suppressing the MAPK pathway in human dermal fibroblasts .
15152989	0	P2-P3_lactone	68,81	thrombin	38,46	P2-P3 lactone	thrombin	null	2147	Chemical	Gene	inhibitor|nmod|START_ENTITY inhibitor|compound|END_ENTITY	Stereoselective synthesis of a potent thrombin inhibitor by a novel P2-P3_lactone ring opening .
17689241	9	P4	1444,1446	COMT	1465,1469	P4	COMT	null	1312	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	In summary , our data demonstrated that P4 downregulates the COMT gene expression through multiple PREs in the COMT promoters and that different progesterone_receptor isoforms have distinctive effects on COMT gene expression .
11917148	1	P4_arginine	151,162	PACE4	166,171	P4 arginine	PACE4	null	5046	Chemical	Gene	role|nmod|START_ENTITY role|nmod|inhibition inhibition|compound|END_ENTITY	A crucial role of the P4_arginine in PACE4 inhibition .
19147651	0	PA12	84,88	angiotensin_II	57,71	PA12	angiotensin II	null	24179(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|dep|effects	Cardiac chymase converts rat proAngiotensin-12 -LRB- PA12 -RRB- to angiotensin_II : effects of PA12 upon cardiac haemodynamics .
11027674	0	PAC	121,124	pituitary_adenylate_cyclase_activating_polypeptide	60,110	PAC	pituitary adenylate cyclase activating polypeptide	null	24166(Tax:10116)	Chemical	Gene	receptor|dep|START_ENTITY receptor|compound|END_ENTITY	Progesterone_receptor activation mediates LH-induced type-I pituitary_adenylate_cyclase_activating_polypeptide receptor -LRB- PAC -LRB- 1 -RRB- -RRB- gene expression in rat granulosa cells .
11303760	0	PACAP-38	44,52	BDNF	0,4	PACAP-38	BDNF	MESH:D051219	24225(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY mediates|dobj|effect mediates|nsubj|END_ENTITY	BDNF mediates the neuroprotective effect of PACAP-38 on rat cortical neurons .
24508136	0	PACAP-38	0,8	CGRP	40,44	PACAP-38	CGRP	MESH:D051219	24241(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|release release|nmod|END_ENTITY	PACAP-38 but not VIP induces release of CGRP from trigeminal nucleus caudalis via a receptor distinct from the PAC1 receptor .
23911909	0	PAF	0,3	MMP-2	13,18	PAF	MMP-2	CHEBI:52450	81686(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|compound|END_ENTITY	PAF enhances MMP-2 production in rat aortic VSMCs via a b-arrestin2-dependent ERK signaling pathway .
17693621	0	PAF	14,17	PAF_acetylhydrolase	32,51	PAF	PAF acetylhydrolase	CHEBI:52450	7941	Chemical	Gene	catabolism|compound|START_ENTITY catabolism|nmod|END_ENTITY	Intracellular PAF catabolism by PAF_acetylhydrolase counteracts continual PAF synthesis .
1903211	0	PAF-acether	26,37	Interferon-gamma	0,16	PAF-acether	Interferon-gamma	MESH:D010972	3458	Chemical	Gene	production|amod|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	Interferon-gamma enhances PAF-acether production by stimulated human polymorphonuclear leucocytes .
11408366	0	PAH	58,61	CYP1A1	75,81	PAH	CYP1A1	CHEBI:33848	1543	Chemical	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	Polycyclic aromatic hydrocarbon/metal mixtures : effect on PAH induction of CYP1A1 in human HEPG2 cells .
19394257	0	PAH	136,139	phenylalanine_hydroxylase	109,134	PAH	phenylalanine hydroxylase	CHEBI:33848	5053	Chemical	Gene	deficiency|appos|START_ENTITY deficiency|compound|END_ENTITY	Genotype-predicted tetrahydrobiopterin -LRB- BH4 -RRB- - responsiveness and molecular genetics in Croatian patients with phenylalanine_hydroxylase -LRB- PAH -RRB- deficiency .
15235594	0	PAH2	51,55	Sin3	34,38	PAH2	Sin3	null	25942	Chemical	Gene	domain|compound|START_ENTITY domain|amod|END_ENTITY	HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations .
18788756	0	PAH_trans-dihydrodiols	13,35	AKR1B10	65,72	PAH trans-dihydrodiols	AKR1B10	null	57016	Chemical	Gene	Oxidation|nmod|START_ENTITY Oxidation|nmod|END_ENTITY	Oxidation of PAH_trans-dihydrodiols by human aldo-keto reductase AKR1B10 .
20345708	0	PAI-749	82,89	plasminogen_activator_inhibitor-1	29,62	PAI-749	plasminogen activator inhibitor-1	MESH:C524408	5054	Chemical	Gene	Effect|amod|START_ENTITY Effect|nmod|END_ENTITY	Effect of the small molecule plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- inhibitor , PAI-749 , in clinical models of fibrinolysis .
20974124	0	PAM-1616	0,8	peroxisome_proliferator-activated_receptor	22,64	PAM-1616	peroxisome proliferator-activated receptor	MESH:C555905	5465	Chemical	Gene	START_ENTITY|appos|modulator modulator|amod|END_ENTITY	PAM-1616 , a selective peroxisome_proliferator-activated_receptor y modulator with preserved anti-diabetic efficacy and reduced adverse effects .
24348888	0	PAX3-FKHR	0,9	pleiotrophin	38,50	PAX3-FKHR	pleiotrophin	null	5764	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	PAX3-FKHR regulates the expression of pleiotrophin to mediate motility in alveolar_rhabdomyosarcoma cells .
10516210	0	PBA	0,3	CFTR	14,18	PBA	CFTR	CHEBI:53317	1080	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	PBA increases CFTR expression but at high doses inhibits Cl -LRB- - -RRB- secretion in Calu-3 airway epithelial cells .
17827067	5	PBI-1393	826,834	IL-2	850,854	PBI-1393	IL-2	null	3558	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	PBI-1393 increases also IL-2 and IFN-gamma mRNA expression as shown by RT-PCR .
14643001	0	PBN	15,18	GLT-1	45,50	PBN	GLT-1	CHEBI:27889	6506	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|levels levels|compound|END_ENTITY	The effects of PBN -LRB- phenyl-butyl-nitrone -RRB- on GLT-1 levels and on the extracellular levels of amino_acids and energy metabolites in a model of iron-induced posttraumatic_epilepsy .
25248683	0	PC407	37,42	COX-2	64,69	PC407	COX-2	MESH:C497664	4513	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|compound|END_ENTITY	Enhanced water-soluble derivative of PC407 as a novel potential COX-2 inhibitor injectable formulation .
8395390	0	PCA_4248	45,53	PAF_receptor	20,32	PCA 4248	PAF receptor	MESH:C066024	58949(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	Interference of the PAF_receptor antagonist , PCA_4248 , with the rat pleurisy evoked by inflammatory mediators or allergen .
25668756	0	PCB3-quinone	72,84	aryl_hydrocarbon_receptor	33,58	PCB3-quinone	aryl hydrocarbon receptor	null	196	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Ligand-independent activation of aryl_hydrocarbon_receptor signaling in PCB3-quinone treated HaCaT human keratinocytes .
16782779	0	PCB_153	0,7	beta-catenin	55,67	PCB 153	beta-catenin	MESH:C014024	12387(Tax:10090)	Chemical	Gene	selects|nsubj|START_ENTITY selects|nmod|END_ENTITY	PCB_153 , a non-dioxin-like_tumor promoter , selects for beta-catenin -LRB- Catnb -RRB- - mutated mouse liver_tumors .
25060310	0	PCBs	54,58	AHR	8,11	PCBs	AHR	MESH:D011078	196	Chemical	Gene	response|nmod|START_ENTITY Role|nmod|response Role|nmod|END_ENTITY	Role of AHR , AHRR and ARNT in response to dioxin-like PCBs in Spaurus aurata .
24215672	0	PCBs	65,69	SF-1	43,47	PCBs	SF-1	MESH:D011078	541229(Tax:9913)	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nmod|effect	Involvement of the orphan nuclear receptor SF-1 in the effect of PCBs , DDT and DDE on the secretion of steroid hormones and oxytocin from bovine granulosa cells .
24576709	0	PCBs	62,66	SF-1	28,32	PCBs	SF-1	MESH:D011078	541229(Tax:9913)	Chemical	Gene	effect|nmod|START_ENTITY involved|nmod|effect involved|nsubjpass|END_ENTITY	The orphan nuclear receptor SF-1 is involved in the effect of PCBs , DDT , and DDE on the secretion of steroid hormones and oxytocin from bovine luteal cells during the estrous cycle in vitro .
7740558	0	PCBs	11,15	cytochrome-P450	34,49	PCBs	cytochrome-P450	MESH:D011078	25251(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|amod|END_ENTITY	Effects of PCBs -LRB- Aroclor_1254 -RRB- on cytochrome-P450 expression and monooxygenase activities in cultured foetal rat hepatocytes .
19374345	0	PCBs	40,44	protein_disulfide_isomerase	60,87	PCBs	protein disulfide isomerase	MESH:D011078	64714	Chemical	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	Hydroxylated polychlorinated_biphenyls -LRB- PCBs -RRB- interact with protein_disulfide_isomerase and inhibit its activity .
15891029	0	PCBs	15,19	thyroid_hormone	25,40	PCBs	thyroid hormone	MESH:D011078	396436(Tax:9031)	Chemical	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	Interaction of PCBs with thyroid_hormone levels and time of hatching in chicken embryos .
25972192	5	PCDD/F	811,817	PCB	820,823	PCDD/F	PCB	null	5091	Chemical	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	There were no significant effects of indicator PCB or PCDD/F + PCB exposure levels on growth -LRB- height , weight , and bone age -RRB- among 8-year-old boys or girls .
26344742	0	PCEP	98,102	Caspase-1	0,9	PCEP	Caspase-1	null	12362(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Secretion Secretion|compound|END_ENTITY	Caspase-1 Dependent IL-1b Secretion and Antigen-Specific T-Cell Activation by the Novel Adjuvant , PCEP .
26344742	0	PCEP	98,102	Caspase-1	0,9	PCEP	Caspase-1	null	12362(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Secretion Secretion|compound|END_ENTITY	Caspase-1 Dependent IL-1b Secretion and Antigen-Specific T-Cell Activation by the Novel Adjuvant , PCEP .
26344742	0	PCEP	98,102	IL-1b	20,25	PCEP	IL-1b	null	16176(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Secretion Secretion|compound|END_ENTITY	Caspase-1 Dependent IL-1b Secretion and Antigen-Specific T-Cell Activation by the Novel Adjuvant , PCEP .
26344742	0	PCEP	98,102	IL-1b	20,25	PCEP	IL-1b	null	16176(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Secretion Secretion|compound|END_ENTITY	Caspase-1 Dependent IL-1b Secretion and Antigen-Specific T-Cell Activation by the Novel Adjuvant , PCEP .
25505847	0	PCI-24781	0,9	EZH2	25,29	PCI-24781	EZH2	MESH:C512352	2146	Chemical	Gene	down-regulates|compound|START_ENTITY END_ENTITY|nsubj|down-regulates	PCI-24781 down-regulates EZH2 expression and then promotes glioma apoptosis by suppressing the PIK3K/Akt/mTOR pathway .
18042714	0	PCI-24781	15,24	RAD51	35,40	PCI-24781	RAD51	MESH:C512352	5888	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|compound|END_ENTITY	HDAC inhibitor PCI-24781 decreases RAD51 expression and inhibits homologous recombination .
16283486	0	PCK3145	24,31	MMP-9	41,46	PCK3145	MMP-9	null	4318	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|compound|END_ENTITY	A PSP94-derived peptide PCK3145 inhibits MMP-9 secretion and triggers CD44 cell surface shedding : implication in tumor metastasis .
16550001	0	PCK3145	75,82	MMP-9	14,19	PCK3145	MMP-9	null	4318	Chemical	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Inhibition of MMP-9 secretion by the anti-metastatic PSP94-derived peptide PCK3145 requires cell surface laminin receptor signaling .
9843709	0	PCMBS	10,15	aquaporin_1	66,77	PCMBS	aquaporin 1	MESH:D002731	443817(Tax:8355)	Chemical	Gene	Effect|nmod|START_ENTITY oocytes|nsubj|Effect oocytes|xcomp|expressing expressing|dobj|END_ENTITY	Effect of PCMBS on CO2 permeability of Xenopus oocytes expressing aquaporin_1 or its C189S mutant .
15595924	4	PCN	833,836	PXR	863,866	PCN	PXR	MESH:D011285	18171(Tax:10090)	Chemical	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	In vitro , PCN directly inhibited hepatic stellate cell transdifferentiation to a profibrogenic phenotype , although the cells did not express the PXR -LRB- in contrast with hepatocytes -RRB- , suggesting that PCN acts independently of the PXR .
18511908	0	PCTA	18,22	TGIF	26,30	PCTA	TGIF	null	7050	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Identification of PCTA , a TGIF antagonist that promotes PML function in TGF-beta signalling .
20332327	0	PD-0325901	20,30	MEK	40,43	PD-0325901	MEK	MESH:C506614	5609	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	A phase II study of PD-0325901 , an oral MEK inhibitor , in previously treated patients with advanced non-small_cell_lung_cancer .
25798061	0	PD-0325901	14,24	MEK	0,3	PD-0325901	MEK	MESH:C506614	5609	Chemical	Gene	Overcomes|compound|START_ENTITY Overcomes|compound|END_ENTITY	MEK Inhibitor PD-0325901 Overcomes Resistance to CK2 Inhibitor CX-4945 and Exhibits Anti-Tumor Activity in Head_and_Neck_Cancer .
25907661	3	PD-0325901	598,608	MEK	561,564	PD-0325901	Dhh	MESH:C506614	13363(Tax:10090)	Chemical	Gene	prior|nmod:npmod|START_ENTITY onset|advmod|prior using|nmod|onset inhibition|acl|using inhibition|compound|END_ENTITY	PROCEDURES : We studied effects of MEK inhibition using 1.5 mg/kg/day PD-0325901 prior to neurofibroma onset in the Nf1 -LRB- flox/flox -RRB- ; Dhh-Cre mouse model .
25977343	0	PD-0325901	14,24	MEK	0,3	PD-0325901	MEK	MESH:C506614	5609	Chemical	Gene	Overcomes|compound|START_ENTITY Overcomes|compound|END_ENTITY	MEK Inhibitor PD-0325901 Overcomes Resistance to PI3K/mTOR Inhibitor PF-5212384 and Potentiates Antitumor Effects in Human Head and Neck Squamous Cell Carcinoma .
25977343	0	PD-0325901	14,24	MEK	0,3	PD-0325901	MEK	MESH:C506614	5609	Chemical	Gene	Overcomes|compound|START_ENTITY Overcomes|compound|END_ENTITY	MEK Inhibitor PD-0325901 Overcomes Resistance to PI3K/mTOR Inhibitor PF-5212384 and Potentiates Antitumor Effects in Human Head and Neck Squamous Cell Carcinoma .
8761988	0	PD-135158	0,9	CCKB	13,17	PD-135158	CCKB	MESH:C065600	887	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	PD-135158 , a CCKB receptor antagonist , microinjected into the nucleus accumbens and the expression of conditioned rewarded behavior .
8951986	0	PD-140548	73,82	CCKA	86,90	PD-140548	CCKA	MESH:C102662	886	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Acquisition of conditioned reward blocked by intra-accumbens infusion of PD-140548 , a CCKA receptor antagonist .
15814200	0	PD-168077	0,9	dopamine_D4_receptor	23,43	PD-168077	dopamine D4 receptor	MESH:C477501	25432(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	PD-168077 , a selective dopamine_D4_receptor agonist , induces penile erection when injected into the paraventricular nucleus of male rats .
11839095	0	PD0166285	91,100	WEE1	104,108	PD0166285	WEE1	MESH:C440869	7465	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Wild-type TP53 inhibits G -LRB- 2 -RRB- - phase checkpoint abrogation and radiosensitization induced by PD0166285 , a WEE1 kinase inhibitor .
17177986	0	PD0166285	44,53	Wee1	29,33	PD0166285	Wee1	MESH:C440869	22390(Tax:10090)	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|amod|END_ENTITY	Cell cycle regulation by the Wee1 inhibitor PD0166285 , pyrido _ -LSB- 2,3-d -RSB- _ pyimidine , in the B16 mouse melanoma cell line .
19649202	0	PD0325901	67,76	BRAF	115,119	PD0325901	BRAF	MESH:C506614	673	Chemical	Gene	START_ENTITY|nmod|mutations mutations|compound|END_ENTITY	Growth-inhibitory and antiangiogenic activity of the MEK inhibitor PD0325901 in malignant_melanoma with or without BRAF mutations .
19649202	0	PD0325901	67,76	MEK	53,56	PD0325901	MEK	MESH:C506614	5609	Chemical	Gene	START_ENTITY|nsubj|activity activity|nmod|inhibitor inhibitor|compound|END_ENTITY	Growth-inhibitory and antiangiogenic activity of the MEK inhibitor PD0325901 in malignant_melanoma with or without BRAF mutations .
22383795	0	PD0332991	52,61	CDK4/6	10,16	PD0332991	CDK4/6	MESH:C500026	1019;1021	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|END_ENTITY	Selective CDK4/6 inhibition with tumor responses by PD0332991 in patients with mantle_cell_lymphoma .
11750912	0	PD098	43,48	MEK	28,31	PD098	MEK	null	5609	Chemical	Gene	inhibitors|dobj|START_ENTITY inhibitors|nsubj|effects effects|nmod|END_ENTITY	Non-specific effects of the MEK inhibitors PD098 ,059 and U0126 on glutamate release from hippocampal synaptosomes .
1957561	0	PD117302	179,187	cholecystokinin	93,108	PD117302	cholecystokinin	MESH:C054718	397468(Tax:9823)	Chemical	Gene	antagonist|appos|START_ENTITY END_ENTITY|nmod|antagonist	Hormonal effects of apomorphine and cholecystokinin in pigs : modification of the response to cholecystokinin by a dopamine antagonist -LRB- metoclopramide -RRB- and a kappa opioid agonist -LRB- PD117302 -RRB- .
15150532	0	PD149163	24,32	Fos	43,46	PD149163	Fos	MESH:C117269	314322(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	The neurotensin agonist PD149163 increases Fos expression in the prefrontal cortex of the rat .
19696185	0	PD153035	32,40	EGFR	0,4	PD153035	EGFR	MESH:C088860	13649(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	EGFR tyrosine kinase inhibitor -LRB- PD153035 -RRB- improves glucose tolerance and insulin action in high-fat diet-fed mice .
23831392	9	PD153035	1216,1224	EGFR	1261,1265	PD153035	EGFR	MESH:C088860	1956	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|tyrosine-kinase tyrosine-kinase|nmod|END_ENTITY	PD153035 , an inhibitor of tyrosine-kinase of EGFR , and BB94 , an inhibitor of metalloprotease which produces a ligand for EGFR , significantly prevented the LPA-induced scattering of A431 cells pretreated with lpa1 or gpr87-siRNA .
25124631	6	PD153035	717,725	EGFR	694,698	PD153035	AQP8	MESH:C088860	343	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	An EGFR kinase inhibitor , PD153035 , blocked EGF-induced AQP8 expression and cell migration and AQP8 expression was decreased from 1.59-fold -LRB- EGF-treated -RRB- to 0.43-fold -LRB- PD153035-treated -RRB- in SiHa .
16413505	0	PD168393	44,52	Epidermal_growth_factor_receptor	0,32	PD168393	Epidermal growth factor receptor	MESH:C509204	1956	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Epidermal_growth_factor_receptor inhibitor -LRB- PD168393 -RRB- potentiates cytotoxic effects of paclitaxel against androgen-independent_prostate_cancer cells .
14521923	0	PD169316	24,32	p38	4,7	PD169316	p38	MESH:C408604	1432	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	The p38 MAPK inhibitor , PD169316 , inhibits transforming_growth_factor_beta-induced Smad signaling in human ovarian_cancer cells .
24045665	0	PD173074	20,28	AP-1	104,108	PD173074	AP-1	MESH:C115711	3726	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	The FGFR1 inhibitor PD173074 induces mesenchymal-epithelial transition through the transcription factor AP-1 .
24398778	0	PD173074	32,40	FGFR	14,18	PD173074	FGFR	MESH:C115711	2263	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Inhibition of FGFR signaling by PD173074 improves antitumor immunity and impairs breast_cancer metastasis .
23908597	0	PD173074	65,73	FGFR2	25,30	PD173074	FGFR2	MESH:C115711	2263	Chemical	Gene	confer|nmod|START_ENTITY confer|nsubj|mutations mutations|nmod|END_ENTITY	The N550K/H mutations in FGFR2 confer differential resistance to PD173074 , dovitinib , and ponatinib_ATP-competitive inhibitors .
21483442	0	PD184352	18,26	CD34	68,72	PD184352	CD34	MESH:C120227	947	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|apoptosis apoptosis|nmod|cells cells|compound|END_ENTITY	The MEK inhibitor PD184352 enhances BMS-214662-induced apoptosis in CD34 + CML stem/progenitor cells .
14613031	0	PD184352	9,17	MEK	64,67	PD184352	MEK	MESH:C120227	5609	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	CI-1040 -LRB- PD184352 -RRB- , a targeted signal transduction inhibitor of MEK -LRB- MAPKK -RRB- .
10903877	5	PD98059	751,758	ERK	699,702	PD98059	ERK	MESH:C093973	24338(Tax:10116)	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|activation activation|compound|END_ENTITY	ERK activation in CRAC was selectively inhibited by PD98059 , a MEK inhibitor .
16125295	8	PD98059	988,995	ERK	1013,1016	PD98059	JNK	MESH:C093973	5599	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|MEK1/2 MEK1/2|compound|END_ENTITY	Cell death induced by H2O2 was prevented by PD98059 , an inhibitor of ERK upstream kinase MEK1/2 .
16293103	7	PD98059	1196,1203	ERK	1143,1146	PD98059	ERK	MESH:C093973	5594	Chemical	Gene	pathway|dep|START_ENTITY pathway|compound|END_ENTITY	When haemocytes were preincubated with PKC inhibitors -LRB- calphostin C or GF109203X -RRB- or inhibitors of the ERK -LRB- extracellular-signal-regulated_kinase -RRB- pathway -LRB- PD98059 or U0126 -RRB- prior to challenge , significant reductions in PKC and ERK phosphorylation and NO production were observed following exposure to laminarin or PMA .
22005927	7	PD98059	1203,1210	ERK	1188,1191	PD98059	p38	MESH:C093973	81649(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Signal transduction studies indicated that the ox-LDL-induced MCP-1 expression in VSMCs could be partly reversed by the inhibitor of p38 MAPK -LRB- SB203580 -RRB- and NF-kB -LRB- BAY11-7082 -RRB- , whereas the ERK inhibitor -LRB- PD98059 -RRB- and the JNK inhibitor -LRB- SP600125 -RRB- had no effect .
24424889	11	PD98059	1805,1812	ERK	1839,1842	PD98059	p53	MESH:C093973	7157	Chemical	Gene	prevented|nmod|START_ENTITY prevented|xcomp|suggesting suggesting|dobj|involvement involvement|nmod|END_ENTITY	MHY-449-induced apoptosis was partially prevented by pretreatment with the ERK inhibitor PD98059 suggesting involvement of ERK in the MHY-449-induced apoptosis .
25136830	4	PD98059	671,678	ERK	663,666	PD98059	PKA	MESH:C093973	25636(Tax:10116)	Chemical	Gene	extracellular_signal-regulated_kinase|nmod|START_ENTITY extracellular_signal-regulated_kinase|appos|END_ENTITY	Inhibition of extracellular_signal-regulated_kinase -LRB- ERK -RRB- by PD98059 decreased ET-1 - and stretch-induced increase of ATF3 protein but not ATF3 mRNA levels , whereas protein_kinase_A -LRB- PKA -RRB- inhibitor H89 attenuated both ATF3 mRNA transcription and protein expression in response to ET-1 and stretch .
17991320	12	PD98059	1452,1459	ERK1/2	1426,1432	PD98059	leptin	MESH:C093973	3952	Chemical	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Blocking ERK1/2 phosphorylation by PD98059 significantly reduced the proliferation of Ishikawa cells stimulated by leptin .
16729971	0	PD98059	75,82	ERK_2	23,28	PD98059	ERK 2	MESH:C093973	5594	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|expression expression|nmod|END_ENTITY	Elevated expression of ERK_2 in human tumor cells chronically treated with PD98059 .
23405080	7	PD98059	1696,1703	JNK	1512,1515	PD98059	p38	MESH:C093973	5594	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Additionally , the specific JNK inhibitor SP600125 or JNK-specific small interference RNA -LRB- si-RNA -RRB- transfection suppressed Cd-induced b-cell apoptosis and related signals , but not ERK1/2 and p38-MAPK inhibitors -LRB- PD98059 and SB203580 -RRB- did not .
10486268	0	PD98059	94,101	MEK	79,82	PD98059	MEK	MESH:C093973	5609	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|Induction Induction|appos|END_ENTITY	Induction of apoptosis in luteinized granulosa cells by the MAP_kinase_kinase -LRB- MEK -RRB- inhibitor PD98059 .
10776691	0	PD98059	19,26	MEK	4,7	PD98059	MEK	MESH:C093973	5609	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	The MEK inhibitor , PD98059 , reduces survival but does not block acute_myeloid_leukemia blast maturation in vitro .
11322796	0	PD98059	17,24	MEK	2,5	PD98059	MEK	MESH:C093973	5609	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nsubj|inhibitor inhibitor|compound|END_ENTITY	A MEK inhibitor , PD98059 enhances IL-1-induced NF-kappaB activation by the enhanced and sustained degradation of IkappaBalpha .
9918526	4	PD98059	917,924	MEK	926,929	PD98059	AT2	MESH:C093973	186	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	To determine whether tyrosine kinases and ERKs influence Ang II-stimulated responses , cells were pretreated with 10 -LRB- -5 -RRB- mol/L tyrphostin_A-23 -LRB- tyrosine kinase inhibitor -RRB- and PD98059 -LRB- MEK inhibitor -RRB- .
10198244	0	PD98059	43,50	MEK1	54,58	PD98059	MEK1	MESH:C093973	170851(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Nonspecific inhibition of myogenic tone by PD98059 , a MEK1 inhibitor , in rat middle cerebral arteries .
21769870	7	PD98059	939,946	TrkB	998,1002	PD98059	BDNF	MESH:C093973	627	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	PD98059 , an ERK inhibitor , K252a , a specific inhibitor for TrkB , a high affinity receptor of BDNF , and an anti-integrin a -LRB- V -RRB- b -LRB- 3 -RRB- antibody suppressed the BDNF-induced migration .
9495809	0	PD98059	0,7	aryl_hydrocarbon_receptor	43,68	PD98059	aryl hydrocarbon receptor	MESH:C093973	196	Chemical	Gene	antagonist|nsubj|START_ENTITY antagonist|nmod|END_ENTITY	PD98059 is an equipotent antagonist of the aryl_hydrocarbon_receptor and inhibitor of mitogen-activated_protein_kinase_kinase .
21236341	0	PD98059	40,47	estrogen_receptor_alpha	62,85	PD98059	estrogen receptor alpha	MESH:C093973	2099	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Estrogenic effect of the MEK1 inhibitor PD98059 on endogenous estrogen_receptor_alpha and beta .
20720174	0	PDH	21,24	PGC-1alpha	0,10	PDH	PGC-1alpha	null	19017(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|increases increases|amod|END_ENTITY	PGC-1alpha increases PDH content but does not change acute PDH regulation in mouse skeletal muscle .
20137123	0	PDMP	11,15	glucosylceramide_synthase	19,44	PDMP	glucosylceramide synthase	MESH:C033110	7357	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	-LSB- Effect of PDMP , a glucosylceramide_synthase inhibitor , on reversion of daunorubicin resistance in human leukemia cell line K562/A02 -RSB- .
25498501	0	PDMP	40,44	glucosylceramide_synthase	4,29	PDMP	glucosylceramide synthase	MESH:C033110	7357	Chemical	Gene	START_ENTITY|nsubj|inhibitor inhibitor|amod|END_ENTITY	The glucosylceramide_synthase inhibitor PDMP sensitizes pancreatic_cancer cells to MEK/ERK inhibitor AZD-6244 .
8086032	0	PDMP	40,44	glucosylceramide_synthase	70,95	PDMP	glucosylceramide synthase	MESH:C033110	7357	Chemical	Gene	chemotherapy|nmod|START_ENTITY Rationales|nmod|chemotherapy Rationales|appos|inhibitor inhibitor|nmod|END_ENTITY	Rationales for cancer chemotherapy with PDMP , a specific inhibitor of glucosylceramide_synthase .
24963944	0	PDTC	48,52	NF-kB	57,62	PDTC	NF-kB	MESH:C066229	81736(Tax:10116)	Chemical	Gene	Effect|appos|START_ENTITY Effect|nmod|activation activation|amod|END_ENTITY	Effect of ammonium_pyrrolidine_dithiocarbamate -LRB- PDTC -RRB- on NF-kB activation and CYP2E1 content of rats with immunological liver_injury .
26064215	0	PDTC	11,15	NF-kB	19,24	PDTC	NF-kB	C020972	81736(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|amod|END_ENTITY	Effects of PDTC on NF-kB expression and apoptosis in rats with severe_acute_pancreatitis-associated lung_injury .
18755694	0	PDZ	22,25	CXCR2	61,66	PDZ	CXCR2	null	3579	Chemical	Gene	motif|compound|START_ENTITY motif|nmod|END_ENTITY	The carboxyl-terminal PDZ ligand motif of chemokine receptor CXCR2 modulates post-endocytic sorting and cellular chemotaxis .
12446668	1	PDZ	95,98	Erbin	89,94	PDZ	Erbin	null	55914	Chemical	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	Structure determination and mutagenesis of the Erbin PDZ domain .
15255944	5	PDZ	551,554	IRSp53	572,578	PDZ	IRSp53	null	10458	Chemical	Gene	motif|compound|START_ENTITY motif|nmod|END_ENTITY	Interaction is mediated by a C-terminal PDZ binding motif in IRSp53 and the second PDZ domain of PSD-95 .
9537516	0	PDZ	47,50	MUPP1	32,37	PDZ	MUPP1	null	8777	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	Cloning and characterization of MUPP1 , a novel PDZ domain protein .
14580213	0	PDZ	13,16	NHE3	26,30	PDZ	NHE3	null	6550	Chemical	Gene	motif|compound|START_ENTITY motif|nmod|END_ENTITY	A C-terminal PDZ motif in NHE3 binds NHERF-1 and enhances cAMP inhibition of sodium-hydrogen exchange .
17287269	0	PDZ	34,37	PATJ	0,4	PDZ	PATJ	null	10207	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	PATJ , a tight junction-associated PDZ protein , is a novel degradation target of high-risk human_papillomavirus E6 and the alternatively spliced isoform 18 E6 .
15774468	0	PDZ	66,69	PICK1	80,85	PDZ	PICK1	null	9463	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Molecular determinants for the complex binding specificity of the PDZ domain in PICK1 .
14559234	0	PDZ	46,49	PSD-95	60,66	PDZ	PSD-95	null	13385(Tax:10090)	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Slo2 sodium-activated K + channels bind to the PDZ domain of PSD-95 .
25158884	0	PDZ	75,78	PTPN4	62,67	PDZ	PTPN4	null	5775	Chemical	Gene	domain|compound|START_ENTITY END_ENTITY|nmod|domain	Regulation of the catalytic activity of the human phosphatase PTPN4 by its PDZ domain .
22595022	0	PDZ	68,71	Preso	0,5	PDZ	Preso	null	9758	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|compound|END_ENTITY	Preso regulation of dendritic_outgrowth through PI -LRB- 4,5 -RRB- P2-dependent PDZ interaction with bPix .
20145126	0	PDZ	145,148	Syntenin	171,179	PDZ	Syntenin	null	6386	Chemical	Gene	protein|compound|START_ENTITY protein|dep|END_ENTITY	Activation of the integrin effector kinase focal_adhesion_kinase in cancer cells is regulated by crosstalk between protein_kinase_Calpha and the PDZ adapter protein mda-9 / Syntenin .
16263794	0	PDZ	0,3	Tax	28,31	PDZ	Tax	null	1491938(Tax:11908)	Chemical	Gene	motif|compound|START_ENTITY motif|nmod|END_ENTITY	PDZ binding motif of HTLV-1 Tax promotes virus-mediated T-cell proliferation in vitro and persistence in vivo .
23395182	0	PDZ	27,30	Tiam1	21,26	PDZ	Tiam1	null	7074	Chemical	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	The structure of the Tiam1 PDZ domain / phospho-syndecan1 complex reveals a ligand conformation that modulates protein dynamics .
24813123	0	PDZ	61,64	erbin	55,60	PDZ	erbin	null	55914	Chemical	Gene	domain|compound|START_ENTITY domain|amod|END_ENTITY	Alteration of the C-terminal ligand specificity of the erbin PDZ domain by allosteric mutational effects .
9546224	0	PDZ	31,34	hCASK	25,30	PDZ	hCASK	null	8573	Chemical	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	Crystal structure of the hCASK PDZ domain reveals the structural basis of class II PDZ domain target recognition .
19047374	0	PDZ	12,15	myotilin	37,45	PDZ	myotilin	null	9499	Chemical	Gene	motif|compound|START_ENTITY motif|nmod|END_ENTITY	A class III PDZ binding motif in the myotilin and FATZ families binds enigma family proteins : a common link for Z-disc myopathies .
11031113	0	PDZ	92,95	nNOS	87,91	PDZ	nNOS	null	4842	Chemical	Gene	domain|compound|START_ENTITY domain|amod|END_ENTITY	Formation of nNOS/PSD -95 PDZ dimer requires a preformed beta-finger structure from the nNOS PDZ domain .
17240990	0	PDZ	48,51	protein_tyrosine_phosphatase_1E	68,99	PDZ	protein tyrosine phosphatase 1E	null	5783	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Energetics of peptide recognition by the second PDZ domain of human protein_tyrosine_phosphatase_1E .
20839809	0	PDZ	106,109	protein_tyrosine_phosphatase_1E	120,151	PDZ	protein tyrosine phosphatase 1E	null	5783	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Crystallographic and nuclear magnetic resonance evaluation of the impact of peptide binding to the second PDZ domain of protein_tyrosine_phosphatase_1E .
19228696	0	PDZ	45,48	syndecan-1	34,44	PDZ	syndecan-1	null	6382	Chemical	Gene	domain|compound|START_ENTITY domain|amod|END_ENTITY	Tyrosine dephosphorylation of the syndecan-1 PDZ binding domain regulates syntenin-1 recruitment .
9108109	6	PD_098059	1324,1333	MEK	1359,1362	PD 098059	NGF	MESH:C093973	4803	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	NGF suppression of ROS formation was prevented by PD_098059 , a specific inhibitor of MEK -LRB- mitogen/extracellular _ receptor_kinase , which phosphorylates mitogen-activated protein kinase -RRB- .
7791115	0	PD_156707	36,45	ETA	64,67	PD 156707	ETA	MESH:C093321	1909	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Pharmacological characterization of PD_156707 , an orally active ETA receptor antagonist .
8764334	0	PD_156707	36,45	Endothelin_A_receptor	0,21	PD 156707	Endothelin A receptor	MESH:C093321	397457(Tax:9823)	Chemical	Gene	antagonism|nmod|START_ENTITY antagonism|compound|END_ENTITY	Endothelin_A_receptor antagonism by PD_156707 does not reduce infarct size after coronary_artery_occlusion / reperfusion in pigs .
10987832	0	PD_173074	20,29	FGFR1	4,9	PD 173074	FGFR1	MESH:C115711	79114(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|inhibitor inhibitor|compound|END_ENTITY	The FGFR1 inhibitor PD_173074 selectively and potently antagonizes FGF-2 neurotrophic and neurotropic effects .
20648624	0	PED	0,3	Rac1	19,23	PED	Rac1	null	5879	Chemical	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	PED interacts with Rac1 and regulates cell migration/invasion processes in human non-small_cell_lung_cancer cells .
15811166	0	PEEP	50,54	EGF	72,75	PEEP	EGF	CHEBI:60683	1950	Chemical	Gene	START_ENTITY|nmod|PEEP PEEP|nmod|concentration concentration|compound|END_ENTITY	Comparison of the effect of aminophylline and low PEEP vs. high PEEP on EGF concentration in critically ill patients with ALI/ARDS .
15811166	0	PEEP	64,68	EGF	72,75	PEEP	EGF	CHEBI:60683	1950	Chemical	Gene	START_ENTITY|nmod|concentration concentration|compound|END_ENTITY	Comparison of the effect of aminophylline and low PEEP vs. high PEEP on EGF concentration in critically ill patients with ALI/ARDS .
20602568	9	PEG	981,984	Asc	987,990	PEG	Asc	CHEBI:46793	29108	Chemical	Gene	group|compound|START_ENTITY group|compound|END_ENTITY	Successful colon cleansing was achieved in 90.6 % in the PEG + Asc group compared to 96 % in the PEG group -LRB- not significant -RRB- .
26485181	0	PEG	113,116	CO2	120,123	PEG	CO2	CHEBI:46793	717	Chemical	Gene	START_ENTITY|nmod|Capture Capture|compound|END_ENTITY	Role of Additives in Composite PEI/Oxide CO2 Adsorbents : Enhancement in the Amine Efficiency of Supported PEI by PEG in CO2 Capture from Simulated Ambient Air .
18258851	0	PEG	59,62	Ccl2	14,18	PEG	Ccl2	CHEBI:46793	20296(Tax:10090)	Chemical	Gene	blockade|nmod|START_ENTITY blockade|amod|END_ENTITY	Late onset of Ccl2 blockade with the Spiegelmer mNOX-E36-3 ` PEG prevents glomerulosclerosis and improves glomerular filtration rate in db/db mice .
18258851	8	PEG	1234,1237	Ccl2	1257,1261	PEG	Ccl2	CHEBI:46793	20296(Tax:10090)	Chemical	Gene	reduced|dep|START_ENTITY reduced|dobj|mRNA mRNA|compound|END_ENTITY	mNOX-E36-3 ` PEG also reduced renal Ccl2 mRNA and protein expression compared with control Spiegelmer-treated 1K db/db mice of the same age .
12225796	0	PEG-rHuMGDF	88,99	megakaryocyte_growth_and_development_factor	43,86	PEG-rHuMGDF	megakaryocyte growth and development factor	MESH:C103117	7066	Chemical	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	The effects of pegylated recombinant human megakaryocyte_growth_and_development_factor -LRB- PEG-rHuMGDF -RRB- on platelet recovery in breast_cancer patients undergoing autologous bone marrow transplantation .
1861535	0	PEG2-ASP	75,83	L-asparaginase	59,73	PEG2-ASP	L-asparaginase	MESH:C070137	80150	Chemical	Gene	efficacy|appos|START_ENTITY efficacy|nmod|END_ENTITY	High efficacy of monomethoxypolyethylene_glycol-conjugated L-asparaginase -LRB- PEG2-ASP -RRB- in two patients with hematological_malignancies .
26093057	0	PEGylated_Liposomal_Doxorubicin	61,92	CCL2	20,24	PEGylated Liposomal Doxorubicin	CCL2	MESH:C506643	6347	Chemical	Gene	Roles|nmod|START_ENTITY Roles|nmod|END_ENTITY	Roles of Chemokines CCL2 and CCL5 in the Pharmacokinetics of PEGylated_Liposomal_Doxorubicin in vivo and in Patients with Recurrent Epithelial_Ovarian_Cancer .
21426935	0	PEGylated_curcumin	42,60	Nrf2	79,83	PEGylated curcumin	Nrf2	null	4780	Chemical	Gene	analogs|amod|START_ENTITY analogs|nmod|END_ENTITY	Design , synthesis and evaluation of novel PEGylated_curcumin analogs as potent Nrf2 activators in human bronchial epithelial cells .
19388934	0	PEP005	29,35	NF-kappaB	46,55	PEP005	NF-kappaB	MESH:C486592	4790	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	The protein kinase C agonist PEP005 increases NF-kappaB expression , induces differentiation and increases constitutive chemokine release by primary acute_myeloid_leukaemia cells .
21885032	0	PERIOSTIN	0,9	MMP-2	20,25	PERIOSTIN	MMP-2	null	4313	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	PERIOSTIN regulates MMP-2 expression via the avb3 integrin/ERK pathway in human periodontal ligament cells .
27021566	0	PERindopril	159,170	ACE	46,49	PERindopril	ACE	MESH:D020913	1636	Chemical	Gene	GENEtic|compound|START_ENTITY Therapy|dep|GENEtic Angiotensin-Converting_Enzyme|dep|Therapy Angiotensin-Converting_Enzyme|appos|END_ENTITY	Individualized Angiotensin-Converting_Enzyme -LRB- ACE -RRB- - Inhibitor Therapy in Stable Coronary Artery Disease Based on Clinical and Pharmacogenetic Determinants : The PERindopril GENEtic -LRB- PERGENE -RRB- Risk Model .
27021566	0	PERindopril	159,170	Angiotensin-Converting_Enzyme	15,44	PERindopril	Angiotensin-Converting Enzyme	MESH:D020913	1636	Chemical	Gene	GENEtic|compound|START_ENTITY Therapy|dep|GENEtic END_ENTITY|dep|Therapy	Individualized Angiotensin-Converting_Enzyme -LRB- ACE -RRB- - Inhibitor Therapy in Stable Coronary Artery Disease Based on Clinical and Pharmacogenetic Determinants : The PERindopril GENEtic -LRB- PERGENE -RRB- Risk Model .
22541754	0	PF-00734200	45,56	DPP-IV	60,66	PF-00734200	DPP-IV	MESH:C558848	1803	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	The pharmacokinetics and pharmacodynamics of PF-00734200 , a DPP-IV inhibitor , in healthy Japanese subjects .
17986636	0	PF-00915275	106,117	11betaHSD1	131,141	PF-00915275	11betaHSD1	null	3290	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Modulation of 11beta-hydroxysteroid dehydrogenase -LRB- 11betaHSD -RRB- activity biomarkers and pharmacokinetics of PF-00915275 , a selective 11betaHSD1 inhibitor .
23423489	0	PF-01367338	58,69	PARP	31,35	PF-01367338	PARP	null	142	Chemical	Gene	study|appos|START_ENTITY study|nmod|inhibitor inhibitor|compound|END_ENTITY	A phase II study of the potent PARP inhibitor , Rucaparib -LRB- PF-01367338 , AG014699 -RRB- , with temozolomide in patients with metastatic_melanoma demonstrating evidence of chemopotentiation .
26655846	0	PF-03446962	87,98	Anti-Activin_Receptor-Like_Kinase_1	23,58	PF-03446962	Anti-Activin Receptor-Like Kinase 1	null	94	Chemical	Gene	Phase|dep|START_ENTITY Phase|dep|Study Study|nmod|END_ENTITY	A Phase I Study of the Anti-Activin_Receptor-Like_Kinase_1 -LRB- ALK-1 -RRB- Monoclonal Antibody PF-03446962 in Patients with Advanced_Solid_Tumors .
23944843	0	PF-04254644	106,117	c-Met	161,166	PF-04254644	c-Met	MESH:C551178	24553(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Lessons from -LRB- S -RRB- -6 - -LRB- 1 - -LRB- 6 - -LRB- 1-methyl-1H-pyrazol-4-yl -RRB- - -LSB- 1,2,4 -RSB- triazolo -LSB- 4,3-b -RSB- pyridazin-3-yl -RRB- ethyl -RRB- quinoline -LRB- PF-04254644 -RRB- , an inhibitor of receptor tyrosine kinase c-Met with high protein kinase selectivity but broad phosphodiesterase family inhibition leading to myocardial_degeneration in rats .
19445930	0	PF-04475270	52,63	EP4	68,71	PF-04475270	EP4	MESH:C545122	5734	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Ocular pharmacokinetics and hypotensive activity of PF-04475270 , an EP4 prostaglandin agonist in preclinical models .
21750219	0	PF-04691502	0,11	PI3K	54,58	PF-04691502	PI3K	MESH:C570662	5290	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|kinases kinases|compound|END_ENTITY	PF-04691502 , a potent and selective oral inhibitor of PI3K and mTOR kinases with antitumor activity .
24395457	0	PF-04691502	17,28	PI3K	72,76	PF-04691502	PI3K	MESH:C570662	5293	Chemical	Gene	study|nmod|START_ENTITY study|appos|inhibitor inhibitor|nmod|END_ENTITY	Phase I study of PF-04691502 , a small-molecule , oral , dual inhibitor of PI3K and mTOR , in patients with advanced_cancer .
21924613	2	PF-04862853	128,139	fatty_acid_amide_hydrolase	176,202	PF-04862853	fatty acid amide hydrolase	MESH:C569542	2166	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Discovery of 7-azaspiro -LSB- 3.5 -RSB- nonane urea PF-04862853 , an orally efficacious inhibitor of fatty_acid_amide_hydrolase -LRB- FAAH -RRB- for pain .
22352684	0	PF-04886847	0,11	kallikrein	36,46	PF-04886847	kallikrein	MESH:C559289	9622	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	PF-04886847 -LRB- an inhibitor of plasma kallikrein -RRB- attenuates inflammatory mediators and activation of blood_coagulation in rat model of lipopolysaccharide -LRB- LPS -RRB- - induced sepsis .
25652454	0	PF-05212384	24,35	PI3K	96,100	PF-05212384	PI3K	null	5293	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|nmod|END_ENTITY	First-in-Human Study of PF-05212384 -LRB- PKI-587 -RRB- , a Small-Molecule , Intravenous , Dual Inhibitor of PI3K and mTOR in Patients with Advanced_Cancer .
17483355	0	PF-2341066	55,65	c-Met	48,53	PF-2341066	c-Met	MESH:C520390	4233	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|nmod|END_ENTITY	An orally available small-molecule inhibitor of c-Met , PF-2341066 , exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms .
20072648	0	PF-2341066	55,65	c-Met	48,53	PF-2341066	c-Met	MESH:C520390	17295(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|nmod|END_ENTITY	An orally available small-molecule inhibitor of c-Met , PF-2341066 , reduces tumor burden and metastasis in a preclinical model of ovarian_cancer metastasis .
19843072	0	PF-3512676	30,40	TLR9	17,21	PF-3512676	TLR9	MESH:C483020	54106	Chemical	Gene	agonist|dobj|START_ENTITY agonist|nsubj|study study|nmod|END_ENTITY	Phase I study of TLR9 agonist PF-3512676 in combination with carboplatin and paclitaxel in patients with advanced non-small-cell_lung_cancer .
21464154	0	PF-3512676	74,84	TLR9	86,90	PF-3512676	TLR9	MESH:C483020	54106	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	A phase III randomized study of gemcitabine and cisplatin with or without PF-3512676 -LRB- TLR9 agonist -RRB- as first-line treatment of advanced non-small-cell_lung_cancer .
20888065	0	PF-3512676	49,59	Toll-like_receptor_9	19,39	PF-3512676	Toll-like receptor 9	MESH:C483020	54106	Chemical	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	Phase I trial of a Toll-like_receptor_9 agonist , PF-3512676 -LRB- CPG_7909 -RRB- , in patients with treatment-refractory , cutaneous_T-cell_lymphoma .
21632509	0	PF-3512676	69,79	Toll-like_receptor_9	81,101	PF-3512676	Toll-like receptor 9	MESH:C483020	54106	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Randomized phase III trial of paclitaxel/carboplatin with or without PF-3512676 -LRB- Toll-like_receptor_9 agonist -RRB- as first-line treatment for advanced non-small-cell_lung_cancer .
23485088	0	PF-3512676	55,65	Toll-like_receptor_9	25,45	PF-3512676	Toll-like receptor 9	MESH:C483020	54106	Chemical	Gene	development|amod|START_ENTITY development|nmod|END_ENTITY	Early development of the Toll-like_receptor_9 agonist , PF-3512676 , for the treatment of patients with advanced_cancers .
23792641	0	PF-3512676	43,53	Toll-like_receptor_9	67,87	PF-3512676	Toll-like receptor 9	MESH:C483020	54106	Chemical	Gene	erlotinib|nmod|START_ENTITY trial|nmod|erlotinib trial|appos|CPG_7909 CPG_7909|dep|agonist agonist|compound|END_ENTITY	Phase 2 trial of erlotinib with or without PF-3512676 -LRB- CPG_7909 , a Toll-like_receptor_9 agonist -RRB- in patients with advanced recurrent EGFR-positive non-small_cell_lung_cancer .
18711188	0	PF-3512676	82,92	toll-like_receptor_9	31,51	PF-3512676	toll-like receptor 9	MESH:C483020	54106	Chemical	Gene	trial|amod|START_ENTITY trial|nmod|agonist agonist|amod|END_ENTITY	Randomized phase II trial of a toll-like_receptor_9 agonist oligodeoxynucleotide , PF-3512676 , in combination with first-line taxane plus platinum chemotherapy for advanced-stage non-small-cell_lung_cancer .
24366569	0	PF-3758309	0,10	p21-activated_kinase_4	12,34	PF-3758309	p21-activated kinase 4	MESH:C550923	10298	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	PF-3758309 , p21-activated_kinase_4 inhibitor , suppresses migration and invasion of A549 human lung_cancer cells via regulation of CREB , NF-kB , and b-catenin signalings .
26875984	0	PF-429242	60,69	Site_1_Protease	27,42	PF-429242	Site 1 Protease	MESH:C570314	8720	Chemical	Gene	Effects|appos|START_ENTITY Effects|nmod|Inhibitor Inhibitor|compound|END_ENTITY	Suppressive Effects of the Site_1_Protease -LRB- S1P -RRB- Inhibitor , PF-429242 , on Dengue_Virus_Propagation .
26381178	0	PF-4708671	0,10	Nrf2	73,77	PF-4708671	Nrf2	MESH:C552719	4780	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	PF-4708671 , a specific inhibitor of p70 ribosomal S6_kinase_1 , activates Nrf2 by promoting p62-dependent autophagic degradation of Keap1 .
26381178	0	PF-4708671	0,10	S6_kinase_1	50,61	PF-4708671	S6 kinase 1	MESH:C552719	6198	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	PF-4708671 , a specific inhibitor of p70 ribosomal S6_kinase_1 , activates Nrf2 by promoting p62-dependent autophagic degradation of Keap1 .
21451504	0	PF-4878691	101,111	TLR7	87,91	PF-4878691	TLR7	null	51284	Chemical	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	The innate immune response , clinical outcomes , and ex vivo HCV antiviral efficacy of a TLR7 agonist -LRB- PF-4878691 -RRB- .
21715568	0	PF-4942847	62,72	Hsp_90	100,106	PF-4942847	Hsp 90	MESH:C569693	3320	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Effective targeting of triple-negative breast_cancer cells by PF-4942847 , a novel oral inhibitor of Hsp_90 .
24240111	0	PF-4989216	96,106	PIK3CA	43,49	PF-4989216	PIK3CA	null	5290	Chemical	Gene	harboring|nmod|START_ENTITY harboring|dobj|mutation mutation|compound|END_ENTITY	Targeting small_cell_lung_cancer harboring PIK3CA mutation with a selective oral PI3K inhibitor PF-4989216 .
22084163	0	PF-5274857	74,84	Smoothened	109,119	PF-5274857	Smoothened	MESH:C573117	319757(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Effective targeting of Hedgehog signaling in a medulloblastoma model with PF-5274857 , a potent and selective Smoothened antagonist that penetrates the blood-brain barrier .
25516793	0	PF-543	47,53	Sphingosine_Kinase_1	21,41	PF-543	Sphingosine Kinase 1	MESH:C573330	8877	Chemical	Gene	Structure|nmod|START_ENTITY Structure|nmod|END_ENTITY	Crystal Structure of Sphingosine_Kinase_1 with PF-543 .
27063355	0	PF-543	56,62	sphingosine_kinase_1	14,34	PF-543	sphingosine kinase 1	MESH:C573330	20698(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|inhibitor inhibitor|amod|END_ENTITY	Effect of the sphingosine_kinase_1 selective inhibitor , PF-543 on arterial and cardiac_remodelling in a hypoxic model of pulmonary_arterial_hypertension .
18339875	0	PF-562	84,90	focal_adhesion_kinase	51,72	PF-562	focal adhesion kinase	null	5747	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Antitumor activity and pharmacology of a selective focal_adhesion_kinase inhibitor , PF-562 ,271 .
1397016	0	PF-5901	0,7	platelet-activating_factor	34,60	PF-5901	platelet-activating factor	MESH:C049740	300795(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|synthesis synthesis|amod|END_ENTITY	PF-5901 inhibits gastrointestinal platelet-activating_factor synthesis in vivo .
20427524	3	PF-68742	620,628	Env	656,659	PF-68742	CD4	MESH:C551246	920	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Postfusion and HIV-1 pseudotyping control experiments confirm that PF-68742 is an entry inhibitor with Env as the specific target for antiviral action .
21366665	0	PF-734200	24,33	DPP-IV	37,43	PF-734200	DPP-IV	MESH:C558848	1803	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	The pharmacokinetics of PF-734200 , a DPP-IV inhibitor , in subjects with renal_insufficiency .
24062988	0	PF-8380	26,33	Autotaxin	0,9	PF-8380	Autotaxin	MESH:C550725	5168	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|compound|END_ENTITY	Autotaxin Inhibition with PF-8380 Enhances the Radiosensitivity of Human and Murine Glioblastoma Cell Lines .
23300119	0	PF-8380	0,7	autotaxin	91,100	PF-8380	autotaxin	MESH:C550725	5168	Chemical	Gene	START_ENTITY|dep|relationship relationship|nmod|inhibition inhibition|amod|END_ENTITY	PF-8380 and closely related analogs : synthesis and structure-activity relationship towards autotaxin inhibition and glioma cell viability .
20532254	0	PF9601N	26,33	MAO-B	43,48	PF9601N	MAO-B	MESH:C470996	25750(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Antioxidant properties of PF9601N , a novel MAO-B inhibitor : assessment of its ability to interact with reactive nitrogen species .
21971010	0	PF9601N	83,90	MAO-B	6,11	PF9601N	MAO-B	MESH:C470996	4129	Chemical	Gene	use|nmod|START_ENTITY inhibitors|dep|use inhibitors|amod|END_ENTITY	Novel MAO-B inhibitors : potential therapeutic use of the selective MAO-B inhibitor PF9601N in Parkinson 's _ disease .
24767579	0	PF9601N	48,55	MAO-B	31,36	PF9601N	MAO-B	MESH:C470996	25750(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Neuroprotective effects of the MAO-B inhibitor , PF9601N , in an in vivo model of excitotoxicity .
18331475	0	PF9601N	41,48	Mao-B	25,30	PF9601N	Mao-B	MESH:C470996	4129	Chemical	Gene	N|compound|START_ENTITY N|amod|END_ENTITY	Anti-apoptotic effect of Mao-B inhibitor PF9601N -LSB- N - -LRB- 2-propynyl -RRB- -2 - -LRB- 5-benzyloxy-indolyl -RRB- _ methylamine -RSB- is mediated by p53 pathway inhibition in MPP + - treated SH-SY5Y human dopaminergic cells .
17339635	0	PFMAGO	0,6	MPF2	73,77	PFMAGO	MPF2	null	3295	Chemical	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	PFMAGO , a MAGO NASHI-like factor , interacts with the MADS-domain protein MPF2 from Physalis floridana .
18001061	0	PF_376304	69,78	phosphoinositide_3-kinase	101,126	PF 376304	phosphoinositide 3-kinase	MESH:C527069	298947(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Metabonomic evaluation of metabolic_dysregulation in rats induced by PF_376304 , a novel inhibitor of phosphoinositide_3-kinase .
15003355	0	PG-KII	22,28	NK3	33,36	PG-KII	NK3	null	100135627(Tax:10141)	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Stimulatory effect of PG-KII , an NK3 tachykinin receptor agonist , on isolated pancreatic acini : species-related differences .
20142301	0	PG01037	0,7	dopamine_D3_receptor	17,37	PG01037	dopamine D3 receptor	MESH:C497150	29238(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	PG01037 , a novel dopamine_D3_receptor antagonist , inhibits the effects of methamphetamine in rats .
12826269	0	PG490	18,23	XIAP	114,118	PG490	XIAP	MESH:C001899	331	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Immunosuppressant PG490 -LRB- triptolide -RRB- induces apoptosis through the activation of caspase-3 and down-regulation of XIAP in U937 cells .
12826269	0	PG490	18,23	caspase-3	81,90	PG490	caspase-3	MESH:C001899	836	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Immunosuppressant PG490 -LRB- triptolide -RRB- induces apoptosis through the activation of caspase-3 and down-regulation of XIAP in U937 cells .
10224109	0	PG490	18,23	interleukin-2	53,66	PG490	interleukin-2	MESH:C001899	3558	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Immunosuppressant PG490 -LRB- triptolide -RRB- inhibits T-cell interleukin-2 expression at the level of purine-box/nuclear factor of activated T-cells and NF-kappaB transcriptional activation .
17726044	0	PGA2	31,35	SMAR1	17,22	PGA2	SMAR1	MESH:C100008	54971	Chemical	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	Stabilization of SMAR1 mRNA by PGA2 involves a stem loop structure in the 5 ' UTR .
25275481	0	PGE	43,46	ABCC4	74,79	PGE	ABCC4	MESH:D011458	10257	Chemical	Gene	Transport|nmod|START_ENTITY Transport|nmod|END_ENTITY	Transport of eicosapentaenoic_acid-derived PGE , PGF -LRB- 3a -RRB- , and TXB by ABCC4 .
15619665	4	PGE	742,745	EP1	758,761	PGE	EP4	MESH:D011458	19219(Tax:10090)	Chemical	Gene	receptors|appos|START_ENTITY subtypes|nmod|receptors are|nsubj|subtypes facilitates|ccomp|are facilitates|nsubj|EP3 EP3|nummod|END_ENTITY	There are four subtypes of prostaglandin_E -LRB- PGE -RRB- receptors , EP1 , EP2 , EP3 , and EP4 , and PGE2 facilitates bone resorption by a mechanism mediated by EP2/EP4 .
23824501	0	PGE	8,11	EP1	15,18	PGE	EP1	MESH:D011458	19216(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Role of PGE EP1 receptor in intracerebral_hemorrhage-induced brain_injury .
8604222	0	PGE	24,27	EP1	110,113	PGE	EP1	MESH:D011458	5731	Chemical	Gene	expression|compound|START_ENTITY analysis|nmod|expression analysis|dep|coexpression coexpression|nmod|END_ENTITY	A molecular analysis of PGE receptor -LRB- EP -RRB- expression on normal and transformed B lymphocytes : coexpression of EP1 , EP2 , EP3beta and EP4 .
9504958	0	PGE	76,79	EP1	61,64	PGE	EP1	MESH:D011458	19216(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY subtype|nmod|receptor subtype|nummod|END_ENTITY	Prostaglandin_E2 -LRB- PGE2 -RRB- autoamplifies its production through EP1 subtype of PGE receptor in mouse osteoblastic MC3T3-E1 cells .
3856900	0	PGE1	35,39	prostaglandin_E1_or_E2	11,33	PGE1	prostaglandin E1 or E2	MESH:D000527	6044	Chemical	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of prostaglandin_E1_or_E2 -LRB- PGE1 ; PGE2 -RRB- on luteal function and binding of luteinizing hormone in nonpregnant ewes .
12573657	0	PGE2	26,30	Bradykinin	0,10	PGE2	Bradykinin	MESH:D015232	280833(Tax:9913)	Chemical	Gene	enhancement|nmod|START_ENTITY enhancement|compound|END_ENTITY	Bradykinin enhancement of PGE2 signalling in bovine trabecular meshwork cells .
2742591	0	PGE2	22,26	Bradykinin	0,10	PGE2	Bradykinin	MESH:D015232	478666(Tax:9615)	Chemical	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	Bradykinin stimulated PGE2 production is independent of changes in intracellular calcium in MDCK cells .
25871398	0	PGE2	16,20	CD80	32,36	PGE2	CD80	MESH:D015232	12519(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	MPGES-1-derived PGE2 suppresses CD80 expression on tumor-associated phagocytes to inhibit anti-tumor immune responses in breast_cancer .
11128051	0	PGE2	94,98	COX-2	14,19	PGE2	COX-2	MESH:D015232	26198(Tax:10116)	Chemical	Gene	levels|appos|START_ENTITY levels|amod|selective selective|amod|END_ENTITY	Effect of the COX-2 selective inhibitor l-745 ,337 on inflammation and organ prostaglandin_E2 -LRB- PGE2 -RRB- levels in adjuvant arthritic rats .
11327079	4	PGE2	743,747	COX-2	716,721	PGE2	COX-1	MESH:D015232	5742	Chemical	Gene	production|compound|START_ENTITY inhibited|dobj|production inhibited|nsubj|NS-398 NS-398|appos|inhibitor inhibitor|compound|END_ENTITY	NS-398 , a selective COX-2 inhibitor , inhibited PGE2 production by FBS-stimulated cells as completely as indomethacin , a non-selective COX-1 / COX-2 inhibitor .
11399653	0	PGE2	50,54	COX-2	10,15	PGE2	COX-2	MESH:D015232	19225(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY expression|nmod|receptor NS-398|nmod|expression NS-398|compound|END_ENTITY	Effect of COX-2 inhibitor NS-398 on expression of PGE2 receptor subtypes in M-1 mouse CCD cells .
12124326	8	PGE2	915,919	COX-2	1043,1048	PGE2	COX-2	MESH:D015232	17709(Tax:10090)	Chemical	Gene	levels|compound|START_ENTITY attenuated|nsubjpass|levels attenuated|nmod|cells cells|acl|coincubated coincubated|xcomp|indicating indicating|ccomp|induced induced|dobj|expression expression|nmod|END_ENTITY	Prostaglandin -LRB- PG -RRB- E2 synthesis was also increased in PDT-treated cells , and PGE2 levels were attenuated in cells coincubated with NS-398 , indicating that PDT induced the expression of biologically active COX-2 .
12665673	0	PGE2	67,71	COX-2	27,32	PGE2	COX-2	MESH:D015232	19225(Tax:10090)	Chemical	Gene	overexpression|nmod|START_ENTITY overexpression|nmod|results results|compound|END_ENTITY	Neuronal overexpression of COX-2 results in dominant production of PGE2 and altered fever response .
15358633	0	PGE2	82,86	COX-2	76,81	PGE2	COX-2	MESH:D015232	5743	Chemical	Gene	-2|compound|START_ENTITY -2|compound|END_ENTITY	n-3 PUFAs reduce VEGF expression in human colon_cancer cells modulating the COX-2 / PGE2 induced ERK-1_and _ -2 and HIF-1alpha induction pathway .
16741257	0	PGE2	93,97	COX-2	129,134	PGE2	COX-2	MESH:D015232	4513	Chemical	Gene	dependent|advmod|START_ENTITY dependent|nmod|decreases decreases|nmod|levels levels|compound|END_ENTITY	Polyamine-mediated reduction in human airway epithelial migration in response to wounding is PGE2 dependent through decreases in COX-2 and cPLA2 protein levels .
16787416	5	PGE2	1488,1492	COX-2	1537,1542	PGE2	COX-2	MESH:D015232	17709(Tax:10090)	Chemical	Gene	production|compound|START_ENTITY production|acl|coupled coupled|nmod|production production|compound|END_ENTITY	Overall , our data suggest that COX-1 and COX-2 play a distinct role in brain PG biosynthesis , with basal PGE2 production being metabolically coupled with COX-2 and TXB2 production being preferentially linked to COX-1 .
16859832	0	PGE2	13,17	COX-2	57,62	PGE2	COX-2	MESH:D015232	4513	Chemical	Gene	synthesis|nummod|START_ENTITY synthesis|nmod|END_ENTITY	Mediators of PGE2 synthesis and signalling downstream of COX-2 represent potential targets for the prevention/treatment of colorectal_cancer .
17697767	0	PGE2	52,56	COX-2	21,26	PGE2	COX-2	MESH:D015232	5743	Chemical	Gene	suppression|nmod|START_ENTITY suppression|amod|dependent dependent|amod|END_ENTITY	Ciglitazone mediates COX-2 dependent suppression of PGE2 in human non-small_cell_lung_cancer cells .
18479189	0	PGE2	17,21	COX-2	46,51	PGE2	COX-2	MESH:D015232	4513	Chemical	Gene	production|compound|START_ENTITY counteracts|dobj|production counteracts|advcl|dampening dampening|dobj|expression expression|amod|END_ENTITY	GPx2 counteracts PGE2 production by dampening COX-2 and mPGES-1 expression in human colon_cancer cells .
18610745	0	PGE2	47,51	COX-2	0,5	PGE2	COX-2	MESH:D015232	17709(Tax:10090)	Chemical	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	COX-2 as possible target for the inhibition of PGE2 production by Rikko-san in activated macrophage .
19289254	8	PGE2	1384,1388	COX-2	1554,1559	PGE2	COX-2	MESH:D015232	5743	Chemical	Gene	inhibited|compound|START_ENTITY induced|nsubjpass|inhibited exogeneous|acl:relcl|induced induced|nsubjpass|exogeneous induced|advcl|implicating implicating|dobj|role role|nmod|pathway pathway|compound|END_ENTITY	Moreover , exogeneous PGE2 inhibited IS induced PARP cleavage in PC-3 cells and also knockdown of COX-2 by siRNA potentiated IS induced PARP cleavage , thereby implicating the critical role of COX-2 pathway in IS induced apoptosis .
19423863	0	PGE2	111,115	COX-2	0,5	PGE2	COX-2	MESH:D015232	5743	Chemical	Gene	prostanoid|xcomp|START_ENTITY prostanoid|nsubj|limits limits|compound|END_ENTITY	COX-2 limits prostanoid production in activated HUVECs and is a source of PGH2 for transcellular metabolism to PGE2 by tumor cells .
20064241	0	PGE2	77,81	COX-2	54,59	PGE2	COX-2	MESH:D015232	26198(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Norepinephrine enhances the LPS-induced expression of COX-2 and secretion of PGE2 in primary rat microglia .
20554444	0	PGE2	77,81	COX-2	61,66	PGE2	COX-2	MESH:D015232	17709(Tax:10090)	Chemical	Gene	production|compound|START_ENTITY catalyzed|dobj|production catalyzed|nsubj|activity activity|nmod|END_ENTITY	1,5-Diarylimidazoles with strong inhibitory activity against COX-2 catalyzed PGE2 production from LPS-induced RAW 264.7 cells .
22141571	0	PGE2	103,107	COX-2	97,102	PGE2	COX-2	MESH:D015232	17709(Tax:10090)	Chemical	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	Blockade of interleukin-17A protects against coxsackievirus B3-induced myocarditis by increasing COX-2 / PGE2 production in the heart .
22170686	0	PGE2	18,22	COX-2	12,17	PGE2	COX-2	MESH:D015232	4513	Chemical	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	The role of COX-2 / PGE2 in gossypol-induced apoptosis of colorectal_carcinoma cells .
22268508	0	PGE2	15,19	COX-2	76,81	PGE2	COX-2	MESH:D015232	4513	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|acl|signalling signalling|nmod|up-regulation up-regulation|nmod|expression expression|amod|END_ENTITY	Involvement of PGE2 and the cAMP signalling pathway in the up-regulation of COX-2 and mPGES-1 expression in LPS-activated macrophages .
22971613	0	PGE2	133,137	COX-2	127,132	PGE2	COX-2	MESH:D015232	4513	Chemical	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	1,25-Dihydroxyvitamin _ D3 inhibits growth of the breast_cancer cell line MCF-7 and downregulates cytochrome P4501B1 through the COX-2 / PGE2 pathway .
23343326	0	PGE2	23,27	COX-2	17,22	PGE2	COX-2	MESH:D015232	19225(Tax:10090)	Chemical	Gene	Up-regulation|dep|START_ENTITY Up-regulation|nmod|END_ENTITY	Up-regulation of COX-2 / PGE2 by endothelin-1 via MAPK-dependent NF-kB pathway in mouse brain microvascular endothelial cells .
23536473	0	PGE2	74,78	COX-2	52,57	PGE2	COX-2	MESH:D015232	4513	Chemical	Gene	START_ENTITY|dep|induces induces|xcomp|END_ENTITY	Necrosis in DU145_prostate_cancer spheroids induces COX-2 / mPGES-1-derived PGE2 to promote tumor growth and to inhibit T cell activation .
23833955	0	PGE2	40,44	COX-2	34,39	PGE2	COX-2	MESH:D015232	26198(Tax:10116)	Chemical	Gene	Effect|dep|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of M8046 on expression of COX-2 / PGE2 in spinal cord and DRG in rats with neuropathic_pain -RSB- .
24098479	0	PGE2	61,65	COX-2	21,26	PGE2	COX-2	MESH:D015232	5743	Chemical	Gene	production|compound|START_ENTITY decrease|nmod|production leading|xcomp|decrease expression|acl|leading expression|compound|END_ENTITY	TGF-b1 downregulates COX-2 expression leading to decrease of PGE2 production in human lung_cancer A549 cells , which is involved in fibrotic response to TGF-b1 .
24480038	0	PGE2	0,4	COX-2	133,138	PGE2	COX-2	MESH:D015232	17709(Tax:10090)	Chemical	Gene	production|compound|START_ENTITY suppressed|nsubjpass|production suppressed|nmod|inhibition inhibition|nmod|END_ENTITY	PGE2 production is suppressed by chemically-synthesized 7-eicosatrienoic_acid in macrophages through the competitive inhibition of COX-2 .
24902855	0	PGE2	21,25	COX-2	15,20	PGE2	COX-2	MESH:D015232	4513	Chemical	Gene	production|compound|START_ENTITY contributes|nsubj|production END_ENTITY|parataxis|contributes	PAR1-dependent COX-2 / PGE2 production contributes to cell proliferation via EP2 receptors in primary human cardiomyocytes .
24984018	0	PGE2	43,47	COX-2	0,5	PGE2	COX-2	MESH:D015232	17709(Tax:10090)	Chemical	Gene	induction|compound|START_ENTITY contributes|nmod|induction contributes|nsubj|END_ENTITY	COX-2 but not mPGES-1 contributes to renal PGE2 induction and diabetic proteinuria in mice with type-1 diabetes .
25051199	0	PGE2	76,80	COX-2	28,33	PGE2	COX-2	MESH:D015232	5743	Chemical	Gene	production|nummod|START_ENTITY related|nsubjpass|production related|ccomp|affect affect|dobj|END_ENTITY	Areca nut components affect COX-2 , cyclin_B1 / cdc25C and keratin expression , PGE2 production in keratinocyte is related to reactive oxygen species , CYP1A1 , Src , EGFR and Ras signaling .
25319133	3	PGE2	912,916	COX-2	777,782	PGE2	COX-2	MESH:D015232	17709(Tax:10090)	Chemical	Gene	E2|appos|START_ENTITY indicated|nsubj|E2 increased|advcl|indicated increased|dobj|protein protein|appos|-LSB- -LSB-|amod|promoter-driven promoter-driven|amod|END_ENTITY	The exposure of HEI-OC1 cells to IL-1b increased COX-2 protein and mRNA expression , COX-2 promoter-driven luciferase activity and COX-2 enzymatic activity -LSB- as indicated by the increased production of prostaglandin __ E2 -LRB- PGE2 -RRB- , a major COX-2 metabolite -RSB- .
25379644	4	PGE2	598,602	COX-2	648,653	PGE2	IL-1b	MESH:D015232	3553	Chemical	Gene	production|appos|START_ENTITY production|acl|suppressing suppressing|dobj|expression expression|appos|END_ENTITY	It also attenuated prostaglandin_E2 -LRB- PGE2 -RRB- production by suppressing cyclooxygenase-2 -LRB- COX-2 -RRB- expression in a concentration-dependent manner -LRB- from 10 M to 80 M -RRB- without affecting cell viability .
26036909	0	PGE2	101,105	COX-2	148,153	PGE2	COX-2	MESH:D015232	4513	Chemical	Gene	production|nummod|START_ENTITY inhibited|nsubjpass|production inhibited|nmod|blocker blocker|compound|END_ENTITY	The TLR-2 / TLR-6 agonist macrophage-activating lipopeptide-2 augments human NK cell cytotoxicity when PGE2 production by monocytes is inhibited by a COX-2 blocker .
26047642	0	PGE2	75,79	COX-2	90,95	PGE2	COX-2	MESH:D015232	4513	Chemical	Gene	amphiregulin|nmod|START_ENTITY secrete|dobj|amphiregulin secrete|advcl|inducing inducing|dobj|expression expression|compound|END_ENTITY	Human airway smooth muscle cells secrete amphiregulin via bradykinin/COX -2 / PGE2 , inducing COX-2 , CXCL8 and VEGF expression in airway epithelial cells .
26057147	0	PGE2	48,52	COX-2	0,5	PGE2	COX-2	MESH:D015232	4513	Chemical	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	COX-2 induces lytic reactivation of EBV through PGE2 by modulating the EP receptor signaling pathway .
27075590	0	PGE2	28,32	COX-2	59,64	PGE2	COX-2	MESH:D015232	5743	Chemical	Gene	Production|compound|START_ENTITY Production|nmod|END_ENTITY	HSP90 Inhibition Suppresses PGE2 Production via Modulating COX-2 and 15-PGDH Expression in HT-29 Colorectal_Cancer_Cells .
9628259	0	PGE2	43,47	COX-2	137,142	PGE2	COX-2	MESH:D015232	5743	Chemical	Gene	production|appos|START_ENTITY increases|dobj|production increases|advcl|enhancing enhancing|dobj|expression expression|amod|cyclooxygenase_2 cyclooxygenase_2|dep|END_ENTITY	Interleukin-13 increases prostaglandin_E2 -LRB- PGE2 -RRB- production by normal human polymorphonuclear neutrophils by enhancing cyclooxygenase_2 -LRB- COX-2 -RRB- gene expression .
26644581	0	PGE2	19,23	CREB	0,4	PGE2	CREB	MESH:D015232	1385	Chemical	Gene	links|dobj|START_ENTITY links|nsubj|END_ENTITY	CREB pathway links PGE2 signaling with macrophage polarization .
14656653	0	PGE2	0,4	Cox-2	108,113	PGE2	Cox-2	MESH:D015232	17709(Tax:10090)	Chemical	Gene	production|compound|START_ENTITY wear|nsubj|production wear|ccomp|mediated mediated|nmod|pathway pathway|amod|dependent dependent|amod|END_ENTITY	PGE2 and IL-6 production by fibroblasts in response to titanium wear debris particles is mediated through a Cox-2 dependent pathway .
15240110	0	PGE2	56,60	Cox-2	0,5	PGE2	Cox-2	MESH:D015232	5743	Chemical	Gene	abrogates|dobj|START_ENTITY abrogates|nsubj|inhibition inhibition|amod|END_ENTITY	Cox-2 inhibition abrogates Chlamydia_pneumoniae-induced PGE2 and MMP-1 expression .
6314861	0	PGE2	94,98	Cyclooxygenase	0,14	PGE2	Cyclooxygenase	MESH:D015232	403544(Tax:9615)	Chemical	Gene	infusion|nmod|START_ENTITY END_ENTITY|nmod|infusion	Cyclooxygenase products and cyclic_nucleotide levels with infusion of arachidonic_acid , PGI2 , PGE2 , PGF2 , and 6-keto-PGF1 in an isolated dog lung .
11842936	0	PGE2	82,86	EP1	54,57	PGE2	EP1	MESH:D015232	5731	Chemical	Gene	receptors|nummod|START_ENTITY subtypes|nmod|receptors subtypes|compound|END_ENTITY	Binary regulation of interleukin _ -LRB- IL -RRB- -6 production by EP1 and EP2/EP4 subtypes of PGE2 receptors in IL-1beta-stimulated human_gingival_fibroblasts .
15943039	0	PGE2	118,122	EP1	39,42	PGE2	EP1	MESH:D015232	19216(Tax:10090)	Chemical	Gene	production|compound|START_ENTITY bearing|nmod|production subtype|dep|bearing subtype|nsubj|Anorexia Anorexia|nmod|END_ENTITY	Anorexia and cachexia in prostaglandin EP1 and EP3 subtype receptor knockout mice bearing a tumor with high intrinsic PGE2 production and prostaglandin related cachexia .
18178094	0	PGE2	19,23	EP1	33,36	PGE2	EP1	MESH:D015232	5731	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|compound|END_ENTITY	Neuroprotection by PGE2 receptor EP1 inhibition involves the PTEN/AKT pathway .
20484658	0	PGE2	0,4	EP1	66,69	PGE2	EP1	MESH:D015232	5731	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|receptors receptors|amod|+ +|dep|disruption disruption|nmod|END_ENTITY	PGE2 promotes Ca2 + - mediated epithelial barrier disruption through EP1 and EP4 receptors in Caco-2 cell monolayers .
21693121	0	PGE2	8,12	EP1	51,54	PGE2	EP1	MESH:D015232	19216(Tax:10090)	Chemical	Gene	exhibits|nsubj|START_ENTITY exhibits|dobj|anxiolytic-like_activity anxiolytic-like_activity|nmod|receptors receptors|compound|END_ENTITY	Central PGE2 exhibits anxiolytic-like_activity via EP1 and EP4 receptors in a manner dependent on serotonin 5-HT1A , dopamine D1 and GABAA receptors .
23385625	0	PGE2	0,4	EP1	5,8	PGE2	EP1	MESH:D015232	19216(Tax:10090)	Chemical	Gene	Parkinsonism|compound|START_ENTITY Parkinsonism|compound|END_ENTITY	PGE2 EP1 receptor deletion attenuates 6-OHDA-induced Parkinsonism in mice : old switch , new target .
24109429	0	PGE2	16,20	EP1	21,24	PGE2	EP1	MESH:D015232	19216(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Contribution of PGE2 EP1 receptor in hemin-induced neurotoxicity .
26183394	0	PGE2	0,4	EP1	38,41	PGE2	EP1	MESH:D015232	5731	Chemical	Gene	Receptors|compound|START_ENTITY Receptors|nmod|Pathway Pathway|compound|END_ENTITY	PGE2 Modulates GABAA Receptors via an EP1 Receptor-Mediated Signaling Pathway .
26232001	0	PGE2	85,89	EP1	90,93	PGE2	EP1	MESH:D015232	19216(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Intracerebral_hemorrhage outcomes following selective blockade or stimulation of the PGE2 EP1 receptor .
26232001	0	PGE2	85,89	EP1	90,93	PGE2	EP1	MESH:D015232	19216(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Intracerebral_hemorrhage outcomes following selective blockade or stimulation of the PGE2 EP1 receptor .
26648273	4	PGE2	560,564	EP1	565,568	PGE2	EP1	MESH:D015232	5731	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	This study aimed to investigate the role of PGE2 EP1 receptor in neurovascular_injury in stroke .
9031929	7	PGE2	1403,1407	EP1	1421,1424	PGE2	EP2	MESH:D015232	5732	Chemical	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	CONCLUSION : Since firstly , PGE2 acts through EP1 , EP2 and EP3 specific receptors , whereas the action of sulprostone is only mediated by EP1 and EP3 , and secondly EP2 receptor is coupled with cAMP production , we conclude that cAMP is involved in mediating the action of PGE2 upon GAG synthesis by human cultured cervical fibroblasts .
9031929	7	PGE2	1645,1649	EP1	1421,1424	PGE2	EP2	MESH:D015232	5732	Chemical	Gene	action|nmod|START_ENTITY mediating|dobj|action involved|advcl|mediating conclude|ccomp|involved conclude|advcl|acts acts|nmod|END_ENTITY	CONCLUSION : Since firstly , PGE2 acts through EP1 , EP2 and EP3 specific receptors , whereas the action of sulprostone is only mediated by EP1 and EP3 , and secondly EP2 receptor is coupled with cAMP production , we conclude that cAMP is involved in mediating the action of PGE2 upon GAG synthesis by human cultured cervical fibroblasts .
9504958	0	PGE2	18,22	EP1	61,64	PGE2	EP1	MESH:D015232	19216(Tax:10090)	Chemical	Gene	Prostaglandin_E2|appos|START_ENTITY autoamplifies|nsubj|Prostaglandin_E2 autoamplifies|nmod|subtype subtype|nummod|END_ENTITY	Prostaglandin_E2 -LRB- PGE2 -RRB- autoamplifies its production through EP1 subtype of PGE receptor in mouse osteoblastic MC3T3-E1 cells .
9843865	0	PGE2	0,4	EP1	22,25	PGE2	EP1	MESH:D015232	25637(Tax:10116)	Chemical	Gene	antagonist|compound|START_ENTITY antagonist|compound|END_ENTITY	PGE2 receptor subtype EP1 antagonist may inhibit central interleukin-1beta-induced fever in rats .
12013525	0	PGE2	36,40	EP2	23,26	PGE2	EP2	MESH:D015232	19217(Tax:10090)	Chemical	Gene	hypercalcemia|compound|START_ENTITY mediates|dobj|hypercalcemia mediates|nsubj|END_ENTITY	Prostaglandin receptor EP2 mediates PGE2 stimulated hypercalcemia in mice in vivo .
14577329	0	PGE2	32,36	EP2	77,80	PGE2	EP2	MESH:D015232	19217(Tax:10090)	Chemical	Gene	receptor|nummod|START_ENTITY subtypes|nmod|receptor Cooperation|nmod|subtypes coupled|nsubj|Cooperation coupled|dobj|-RSB- -RSB-|compound|END_ENTITY	-LSB- Cooperation of two subtypes of PGE2 receptor , Gi coupled EP3 and Gs coupled EP2 or EP4 subtype -RSB- .
14715958	0	PGE2	32,36	EP2	37,40	PGE2	EP2	MESH:D015232	5732	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Neuroprotective function of the PGE2 EP2 receptor in cerebral_ischemia .
15560120	0	PGE2	0,4	EP2	104,107	PGE2	EP2	MESH:D015232	81752(Tax:10116)	Chemical	Gene	exerts|nsubj|START_ENTITY exerts|nmod|release release|nmod|receptor receptor|compound|END_ENTITY	PGE2 exerts its effect on the LPS-induced release of TNF-alpha , ET-1 , IL-1alpha , IL-6 and IL-10 via the EP2 and EP4 receptor in rat liver macrophages .
16251433	0	PGE2	115,119	EP2	120,123	PGE2	EP2	MESH:D015232	5732	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Postsynaptically synthesized prostaglandin_E2 -LRB- PGE2 -RRB- modulates hippocampal synaptic transmission via a presynaptic PGE2 EP2 receptor .
16251433	0	PGE2	47,51	EP2	120,123	PGE2	EP2	MESH:D015232	5732	Chemical	Gene	prostaglandin_E2|appos|START_ENTITY modulates|nsubj|prostaglandin_E2 modulates|dobj|transmission transmission|nmod|receptor receptor|compound|END_ENTITY	Postsynaptically synthesized prostaglandin_E2 -LRB- PGE2 -RRB- modulates hippocampal synaptic transmission via a presynaptic PGE2 EP2 receptor .
16732324	0	PGE2	20,24	EP2	0,3	PGE2	EP2	MESH:D015232	19217(Tax:10090)	Chemical	Gene	receptor|nmod|START_ENTITY END_ENTITY|appos|receptor	EP2 , a receptor for PGE2 , regulates tumor angiogenesis through direct effects on endothelial cell motility and survival .
17931866	0	PGE2	60,64	EP2	68,71	PGE2	EP2	MESH:D015232	5732	Chemical	Gene	START_ENTITY|nmod|receptors receptors|compound|END_ENTITY	Synthesis and evaluation of novel pyrazolidinone analogs of PGE2 as EP2 and EP4 receptors agonists .
18407349	0	PGE2	25,29	EP2	66,69	PGE2	EP2	MESH:D015232	19217(Tax:10090)	Chemical	Gene	play|nsubj|START_ENTITY play|dobj|role role|nmod|receptors receptors|compound|END_ENTITY	Cyclooxygenase-2 derived PGE2 and PGI2 play an important role via EP2 and PPARdelta receptors in early steps of oil induced decidualization in mice .
20451959	0	PGE2	0,4	EP2	59,62	PGE2	EP2	MESH:D015232	5732	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|advcl|activating activating|dobj|END_ENTITY	PGE2 decreases reactivity of human platelets by activating EP2 and EP4 .
20664890	3	PGE2	503,507	EP2	534,537	PGE2	AE1	MESH:D015232	6521	Chemical	Gene	START_ENTITY|nmod|platelets platelets|acl|lacking lacking|dobj|EP2 EP2|appos|END_ENTITY	However , there was no significant change in the inhibitory effect of PGE2 on platelets lacking EP2 -LRB- EP2 - / - platelets -RRB- and EP4 -LRB- EP4 - / - platelets -RRB- compared with the inhibitory effect on WT platelets .
21209948	0	PGE2	0,4	EP2	49,52	PGE2	EP2	MESH:D015232	5732	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|receptors receptors|nummod|END_ENTITY	PGE2 induces IL-6 in orbital fibroblasts through EP2 receptors and increased gene promoter activity : implications to thyroid-associated_ophthalmopathy .
24127286	0	PGE2	25,29	EP2	76,79	PGE2	EP2	MESH:D015232	5732	Chemical	Gene	suppresses|dep|START_ENTITY suppresses|dep|cell cell|acl|migration migration|nmod|inhibition inhibition|nmod|activation activation|compound|END_ENTITY	Silymarin suppresses the PGE2 - induced cell migration through inhibition of EP2 activation ; G protein-dependent PKA-CREB and G protein-independent Src-STAT3 signal pathways .
24902855	0	PGE2	21,25	EP2	75,78	PGE2	EP2	MESH:D015232	5732	Chemical	Gene	production|compound|START_ENTITY contributes|nsubj|production contributes|nmod|proliferation proliferation|nmod|receptors receptors|nummod|END_ENTITY	PAR1-dependent COX-2 / PGE2 production contributes to cell proliferation via EP2 receptors in primary human cardiomyocytes .
9348184	2	PGE2	253,257	EP2	282,285	PGE2	EP4	MESH:D015232	19219(Tax:10090)	Chemical	Gene	subtypes|compound|START_ENTITY subtypes|appos|END_ENTITY	Four major PGE2 receptor subtypes , EP1 , EP2 , EP3 , and EP4 , mediate various PGE2 effects via their coupling to distinct signaling pathways .
9348184	2	PGE2	317,321	EP2	282,285	PGE2	EP4	MESH:D015232	19219(Tax:10090)	Chemical	Gene	effects|compound|START_ENTITY mediate|dobj|effects mediate|nsubj|subtypes subtypes|appos|END_ENTITY	Four major PGE2 receptor subtypes , EP1 , EP2 , EP3 , and EP4 , mediate various PGE2 effects via their coupling to distinct signaling pathways .
11867175	0	PGE2	101,105	EP2-receptor	50,62	PGE2	EP2-receptor	MESH:D015232	19217(Tax:10090)	Chemical	Gene	inhibition|nmod|START_ENTITY END_ENTITY|nmod|inhibition	Contribution of the two Gs-coupled PGE2-receptors EP2-receptor and EP4-receptor to the inhibition by PGE2 of the LPS-induced TNFalpha-formation in Kupffer cells from EP2-or EP4-receptor-deficient mice .
12431904	0	PGE2	41,45	EP2_receptor	82,94	PGE2	EP2 receptor	MESH:D015232	19217(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY mediated|nsubjpass|effects mediated|nmod|END_ENTITY	Prosurvival and antiapoptotic effects of PGE2 in radiation_injury are mediated by EP2_receptor in intestine .
11238561	0	PGE2	42,46	EP3	25,28	PGE2	EP3	MESH:D015232	19218(Tax:10090)	Chemical	Gene	receptor|nmod|START_ENTITY receptor|compound|END_ENTITY	Activation of the murine EP3 receptor for PGE2 inhibits cAMP production and promotes platelet_aggregation .
18652829	0	PGE2	52,56	EP3	84,87	PGE2	EP3	MESH:D015232	5733	Chemical	Gene	binding|compound|START_ENTITY binding|nmod|eLP2 eLP2|nummod|END_ENTITY	Involvement of non-conserved residues important for PGE2 binding to the constrained EP3 eLP2 using NMR and site-directed mutagenesis .
24323317	0	PGE2	30,34	EP3	13,16	PGE2	EP3	MESH:D015232	5733	Chemical	Gene	Blocking|nmod|START_ENTITY Blocking|dobj|receptor receptor|compound|END_ENTITY	Blocking the EP3 receptor for PGE2 with DG-041 decreases thrombosis without impairing haemostatic competence .
26485614	0	PGE2	4,8	EP3	9,12	PGE2	EP3	MESH:D015232	19218(Tax:10090)	Chemical	Gene	Receptor|compound|START_ENTITY Receptor|compound|END_ENTITY	The PGE2 EP3 Receptor Regulates Diet-Induced Adiposity in Male Mice .
9843870	0	PGE2	0,4	EP3	10,13	PGE2	EP3	MESH:D015232	24929(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|receptors receptors|nummod|END_ENTITY	PGE2 , via EP3 receptors , regulates brain nitric_oxide_synthase in the perinatal period .
21723865	0	PGE2	79,83	EP4	98,101	PGE2	EP4	MESH:D015232	5734	Chemical	Gene	signaling|compound|START_ENTITY signaling|nmod|END_ENTITY	Sost down-regulation by mechanical strain in human osteoblastic cells involves PGE2 signaling via EP4 .
22342504	0	PGE2	0,4	EP4	17,20	PGE2	EP4	MESH:D015232	19219(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	PGE2 through the EP4 receptor controls smooth muscle gene expression patterns in the ductus arteriosus critical for remodeling at birth .
8967374	0	PGE2	0,4	ET-1	22,26	PGE2	ET-1	MESH:D015232	281137(Tax:9913)	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|secretion secretion|compound|END_ENTITY	PGE2 and PGI2 inhibit ET-1 secretion from endothelial cells by stimulating particulate guanylate cyclase .
16144964	0	PGE2	44,48	Fibroblast_growth_factor-23	0,27	PGE2	Fibroblast growth factor-23	MESH:D015232	64654(Tax:10090)	Chemical	Gene	production|compound|START_ENTITY increases|dobj|production increases|nsubj|END_ENTITY	Fibroblast_growth_factor-23 increases mouse PGE2 production in vivo and in vitro .
2568278	0	PGE2	16,20	GHRH	58,62	PGE2	GHRH	MESH:D015232	29446(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY -LSB-|dobj|effects -LSB-|nmod|END_ENTITY	-LSB- The effects of PGE2 , 2-DG and L-arginine on hypothalamic GHRH and SRIF releases in conscious rats , with respect to GH secretion -RSB- .
15023863	0	PGE2	116,120	GM-CSF	145,151	PGE2	GM-CSF	MESH:D015232	1437	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|nmod|END_ENTITY	Identification in human airways smooth muscle cells of the prostanoid receptor and signalling pathway through which PGE2 inhibits the release of GM-CSF .
7586701	0	PGE2	146,150	GM-CSF	50,56	PGE2	GM-CSF	MESH:D015232	1437	Chemical	Gene	prostaglandin_E2|appos|START_ENTITY induction|nmod|prostaglandin_E2 monocytes|nmod|induction activity|nmod|monocytes reduces|dobj|activity reduces|nsubj|Granulocyte-macrophage_colony-stimulating_factor Granulocyte-macrophage_colony-stimulating_factor|appos|END_ENTITY	Granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- reduces toxoplasmastatic activity of human monocytes via induction of prostaglandin_E2 -LRB- PGE2 -RRB- .
27075590	0	PGE2	28,32	HSP90	0,5	PGE2	HSP90	MESH:D015232	3320	Chemical	Gene	Production|compound|START_ENTITY Production|compound|END_ENTITY	HSP90 Inhibition Suppresses PGE2 Production via Modulating COX-2 and 15-PGDH Expression in HT-29 Colorectal_Cancer_Cells .
9324053	0	PGE2	18,22	IFN-tau	0,7	PGE2	IFN-tau	MESH:D015232	317698(Tax:9913)	Chemical	Gene	production|compound|START_ENTITY increases|dobj|production increases|nsubj|END_ENTITY	IFN-tau increases PGE2 production and COX-2 gene expression in the bovine endometrium in vitro .
25218510	0	PGE2	0,4	IL-10	14,19	PGE2	IL-10	MESH:D015232	3586	Chemical	Gene	Production|compound|START_ENTITY Production|compound|END_ENTITY	PGE2 Inhibits IL-10 Production via EP2-Mediated b-Arrestin Signaling in Neuroinflammatory_Condition .
26403276	0	PGE2	92,96	IL-1b	65,70	PGE2	IL-1b	MESH:D015232	3553	Chemical	Gene	secretion|nmod|START_ENTITY END_ENTITY|nmod|secretion	The stellate vascular smooth muscle cell phenotype is induced by IL-1b via the secretion of PGE2 and subsequent cAMP-dependent protein kinase A activation .
10198245	5	PGE2	1008,1012	IL-1beta	1035,1043	PGE2	IL-1beta	MESH:D015232	3553	Chemical	Gene	production|nummod|START_ENTITY production|acl|induced induced|nmod|END_ENTITY	The tyrosine kinase inhibitors , Herbimycin_A and PD_153035_hydrochloride , reduced COX-2 mRNA levels as well as PGE2 production induced by IL-1beta or the combination of IL-1beta and EGF whereas COX-1 mRNA levels were not affected .
15135319	0	PGE2	0,4	IL-1beta	13,21	PGE2	IL-1beta	MESH:D015232	16176(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	PGE2 induces IL-1beta gene expression in mouse osteoblasts through a cAMP-PKA signaling pathway .
16427196	0	PGE2	78,82	IL-1beta	59,67	PGE2	IL-1beta	MESH:D015232	24494(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	Peripheral_inflammation modifies the effect of intrathecal IL-1beta on spinal PGE2 production mainly through cyclooxygenase-2 activity .
16741924	0	PGE2	0,4	IL-1beta	30,38	PGE2	IL-1beta	MESH:D015232	3553	Chemical	Gene	amplifies|nsubj|START_ENTITY amplifies|dobj|effects effects|nmod|de-differentiation de-differentiation|amod|END_ENTITY	PGE2 amplifies the effects of IL-1beta on vascular smooth muscle cell de-differentiation : a consequence of the versatility of PGE2 receptors 3 due to the emerging expression of adenylyl_cyclase_8 .
16741924	0	PGE2	126,130	IL-1beta	30,38	PGE2	IL-1beta	MESH:D015232	3553	Chemical	Gene	receptors|nummod|START_ENTITY versatility|nmod|receptors consequence|nmod|versatility de-differentiation|dep|consequence de-differentiation|amod|END_ENTITY	PGE2 amplifies the effects of IL-1beta on vascular smooth muscle cell de-differentiation : a consequence of the versatility of PGE2 receptors 3 due to the emerging expression of adenylyl_cyclase_8 .
16883638	0	PGE2	37,41	IL-1beta	114,122	PGE2	IL-1beta	MESH:D015232	24494(Tax:10116)	Chemical	Gene	release|nummod|START_ENTITY 3-Phenyl-2-Propene-1-ol|nmod|release cells|amod|3-Phenyl-2-Propene-1-ol Effect|nmod|cells stimulated|nsubj|Effect stimulated|nmod|END_ENTITY	Effect of 3-Phenyl-2-Propene-1-ol on PGE2 release from rat cerebral microvascular endothelial cells stimulated by IL-1beta .
17014957	0	PGE2	63,67	IL-1beta	86,94	PGE2	IL-1beta	MESH:D015232	3553	Chemical	Gene	release|nmod|START_ENTITY modulate|dobj|release modulate|nmod|END_ENTITY	Alpha-MSH and gamma-MSH modulate early release of hypothalamic PGE2 and NO induced by IL-1beta differently .
17035941	0	PGE2	40,44	IL-1beta	0,8	PGE2	IL-1beta	MESH:D015232	3553	Chemical	Gene	induction|compound|START_ENTITY VEGF|nmod|induction induces|dobj|VEGF induces|nsubj|END_ENTITY	IL-1beta induces VEGF , independently of PGE2 induction , mainly through the PI3-K/mTOR pathway in renal mesangial cells .
17882968	0	PGE2	69,73	IL-1beta	143,151	PGE2	IL-1beta	MESH:D015232	16176(Tax:10090)	Chemical	Gene	release|nummod|START_ENTITY inhibiting|dobj|release compounds|acl|inhibiting relationship|nmod|compounds induced|nsubj|relationship induced|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Structure-activity relationship of phenylallyl compounds inhibiting PGE2 release in mouse cerebral microvascular endothelial cells induced by IL-1beta -RSB- .
26412948	0	PGE2	0,4	IL-23	14,19	PGE2	IL-23	MESH:D015232	51561	Chemical	Gene	Production|compound|START_ENTITY Production|compound|END_ENTITY	PGE2 Elevates IL-23 Production in Human Dendritic Cells via a cAMP Dependent Pathway .
21044121	0	PGE2	49,53	IL-27	57,62	PGE2	IL-27	MESH:D015232	246778	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|production production|compound|END_ENTITY	Stimulatory effect of LPS and feedback effect of PGE2 on IL-27 production .
25088998	0	PGE2	56,60	IL-27	0,5	PGE2	IL-27	MESH:D015232	246779(Tax:10090)	Chemical	Gene	production|compound|START_ENTITY regulation|nmod|production responses|nmod|regulation affects|dobj|responses affects|nsubj|END_ENTITY	IL-27 affects helper T cell responses via regulation of PGE2 production by macrophages .
12126020	8	PGE2	1099,1103	IL-6	1061,1065	PGE2	IL-8	MESH:D015232	3576	Chemical	Gene	=|nummod|START_ENTITY END_ENTITY|appos|=	The release of IL-6 and PGE2 did not change significantly -LRB- IL-6 , 10.3 versus 6.5 pg/mL , p = .13 ; PGE2 , 13.6 versus 13.4 pg/mL -RRB- , nor did the ciliary beat frequency or the saccharin transport time .
15888106	0	PGE2	110,114	IL-6	70,74	PGE2	IL-6	MESH:D015232	3569	Chemical	Gene	receptors|nummod|START_ENTITY subtypes|nmod|receptors production|nmod|subtypes production|compound|END_ENTITY	Prostaglandin_E2 -LRB- PGE2 -RRB- downregulates interleukin -LRB- IL -RRB- -1 alpha-induced IL-6 production via EP2/EP4 subtypes of PGE2 receptors in human periodontal ligament cells .
15888106	0	PGE2	18,22	IL-6	70,74	PGE2	IL-6	MESH:D015232	3569	Chemical	Gene	Prostaglandin_E2|appos|START_ENTITY downregulates|nsubj|Prostaglandin_E2 downregulates|xcomp|production production|compound|END_ENTITY	Prostaglandin_E2 -LRB- PGE2 -RRB- downregulates interleukin -LRB- IL -RRB- -1 alpha-induced IL-6 production via EP2/EP4 subtypes of PGE2 receptors in human periodontal ligament cells .
16848690	0	PGE2	38,42	IL-6	44,48	PGE2	IL-6	MESH:D015232	3569	Chemical	Gene	invading|dobj|START_ENTITY Targeting|advcl|invading gene-related|advcl|Targeting gene-related|nsubj|END_ENTITY	Targeting invading macrophage-derived PGE2 , IL-6 and calcitonin gene-related peptide in injured nerve to treat neuropathic_pain .
21209948	0	PGE2	0,4	IL-6	13,17	PGE2	IL-6	MESH:D015232	3569	Chemical	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	PGE2 induces IL-6 in orbital fibroblasts through EP2 receptors and increased gene promoter activity : implications to thyroid-associated_ophthalmopathy .
25229003	5	PGE2	821,825	IL-6	806,810	PGE2	IL-6	MESH:D015232	3569	Chemical	Gene	treated|nsubjpass|START_ENTITY treated|advcl|determine determine|nmod|expression expression|nmod|END_ENTITY	To determine the signaling pathway for the expression of PGE2-induced IL-6 and IL-8 , PGE2 was treated with Akt and NF-kB inhibitors in NPDFs .
9126704	0	PGE2	79,83	Lymphotoxin-beta	0,16	PGE2	Lymphotoxin-beta	MESH:D015232	16994(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY regulation|dep|effects regulation|amod|END_ENTITY	Lymphotoxin-beta and TNF regulation in T cell subsets : differential effects of PGE2 .
25956994	0	PGE2	38,42	MMP-3	17,22	PGE2	MMP-3	MESH:D015232	17392(Tax:10090)	Chemical	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	TNF-a stimulates MMP-3 production via PGE2 signalling through the NF-kB and p38_MAPK pathway in a murine cementoblast cell line .
17697767	2	PGE2	416,420	NSCLC	424,429	PGE2	COX-2	MESH:D015232	5743	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Here , we report that ciglitazone downregulates PGE2 in NSCLC cells .
19419302	0	PGE2	0,4	RANKL	67,72	PGE2	RANKL	MESH:D015232	21943(Tax:10090)	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	PGE2 signaling through the EP4 receptor on fibroblasts upregulates RANKL and stimulates osteolysis .
22580611	0	PGE2	0,4	RalA	62,66	PGE2	RalA	MESH:D015232	5898	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	PGE2 promotes renal_carcinoma cell invasion through activated RalA .
25956994	0	PGE2	38,42	TNF-a	0,5	PGE2	TNF-a	MESH:D015232	21926(Tax:10090)	Chemical	Gene	production|nmod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	TNF-a stimulates MMP-3 production via PGE2 signalling through the NF-kB and p38_MAPK pathway in a murine cementoblast cell line .
2507329	0	PGE2	60,64	bradykinin	26,36	PGE2	bradykinin	MESH:D015232	3827	Chemical	Gene	release|compound|START_ENTITY release|amod|END_ENTITY	Interleukin-1 potentiates bradykinin - and TNF_alpha-induced PGE2 release .
3133127	0	PGE2	55,59	bradykinin	19,29	PGE2	bradykinin	MESH:D015232	3827	Chemical	Gene	levels|nummod|START_ENTITY increases|nmod|levels increases|nsubj|Characteristics Characteristics|nmod|END_ENTITY	Characteristics of bradykinin and TPA increases in the PGE2 levels of human urothelial cells .
9435567	0	PGE2	0,4	bradykinin	16,26	PGE2	bradykinin	MESH:D015232	3827	Chemical	Gene	release|nummod|START_ENTITY release|nmod|END_ENTITY	PGE2 release by bradykinin in human airway smooth muscle cells : involvement of cyclooxygenase-2 induction .
16428339	0	PGE2	0,4	brain_natriuretic_peptide	22,47	PGE2	brain natriuretic peptide	MESH:D015232	4879	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	PGE2 stimulates human brain_natriuretic_peptide expression via EP4 and p42/44 MAPK .
7525323	0	PGE2	0,4	c-fos	13,18	PGE2	c-fos	MESH:D015232	14281(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	PGE2 induces c-fos expression by a cAMP-independent mechanism in glomerular mesangial cells .
9547569	0	PGE2	58,62	c-fos	49,54	PGE2	c-fos	MESH:D015232	14281(Tax:10090)	Chemical	Gene	mediate|nmod|START_ENTITY mediate|dobj|induction induction|nmod|END_ENTITY	Distinct signaling pathways mediate induction of c-fos by PGE2 in glomerular mesangial cells .
24915969	0	PGE2	74,78	cPLA2	11,16	PGE2	cPLA2	MESH:D015232	24653(Tax:10116)	Chemical	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	BK Induces cPLA2 Expression via an Autocrine Loop Involving COX-2-Derived PGE2 in Rat Brain Astrocytes .
8928731	0	PGE2	77,81	cPLA2	45,50	PGE2	cPLA2	MESH:D015232	5321	Chemical	Gene	mediates|dobj|START_ENTITY mediates|nsubj|synthesis synthesis|nmod|END_ENTITY	Increased synthesis of high-molecular-weight cPLA2 mediates early UV-induced PGE2 in human skin .
16945943	0	PGE2	125,129	cyclo-oxygenase_2	88,105	PGE2	cyclo-oxygenase 2	MESH:D015232	100135607(Tax:10141)	Chemical	Gene	release|compound|START_ENTITY release|amod|END_ENTITY	Prostaglandin_E2 release in gastric antral mucosa of guinea-pigs : basal PGE2 release by cyclo-oxygenase_2 and ACh-stimulated PGE2 release by cyclo-oxygenase 1 .
14525536	0	PGE2	93,97	cyclooxygenase_1	34,50	PGE2	cyclooxygenase 1	MESH:D015232	282022(Tax:9913)	Chemical	Gene	production|nmod|START_ENTITY END_ENTITY|nmod|production	Evaluation of the contribution of cyclooxygenase_1 and cyclooxygenase_2 to the production of PGE2 and PGF2 alpha in epithelial cells from bovine endometrium .
10690199	0	PGE2	98,102	cyclooxygenase_2	60,76	PGE2	cyclooxygenase 2	MESH:D015232	5743	Chemical	Gene	Correlation|nmod|START_ENTITY Correlation|nmod|END_ENTITY	Correlation of increased concentration of ovine endometrial cyclooxygenase_2 with the increase in PGE2 and PGD2 in the late luteal phase .
1274921	0	PGE2	40,44	gastrin	71,78	PGE2	gastrin	MESH:D015232	2520	Chemical	Gene	START_ENTITY|nmod|response response|compound|END_ENTITY	Effect of synthetic 15-methyl analog of PGE2 on gastric_acid and serum gastrin response to peptone meal , pentagastrin , and histamine in duodenal ulcer patients .
1916130	0	PGE2	36,40	gastrin	11,18	PGE2	gastrin	MESH:D015232	25320(Tax:10116)	Chemical	Gene	analog|compound|START_ENTITY Effect|appos|analog Effect|nmod|END_ENTITY	-LSB- Effect of gastrin and enprostil , a PGE2 analog , on colonic_cancerous cell growth -RSB- .
18157587	0	PGE2	51,55	heme_oxygenase-1	12,28	PGE2	heme oxygenase-1	MESH:D015232	15368(Tax:10090)	Chemical	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	The role of heme_oxygenase-1 in down regulation of PGE2 production by taurine_chloramine and taurine_bromamine in J774 .2 macrophages .
1328792	0	PGE2	10,14	interleukin-1	18,31	PGE2	interleukin-1	MESH:D015232	3552	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|release release|amod|END_ENTITY	Effect of PGE2 on interleukin-1 and superoxide release from primary-cultured human hepatic macrophages .
22803375	0	PGE2	52,56	interleukin-1beta	26,43	PGE2	interleukin-1beta	MESH:D015232	16176(Tax:10090)	Chemical	Gene	production|compound|START_ENTITY production|amod|END_ENTITY	-LSB- Cinnamaldehyde decreases interleukin-1beta induced PGE2 production by down-regulation of mPGES-1 and COX-2 expression in mouse macrophage RAW264 .7 cells -RSB- .
9843870	0	PGE2	0,4	nitric_oxide_synthase	41,62	PGE2	nitric oxide synthase	MESH:D015232	24598(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	PGE2 , via EP3 receptors , regulates brain nitric_oxide_synthase in the perinatal period .
25263346	0	PGE2	0,4	plasminogen_activator_inhibitor-1	34,67	PGE2	plasminogen activator inhibitor-1	MESH:D015232	24617(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	PGE2 reduces MMP-14 and increases plasminogen_activator_inhibitor-1 in cardiac fibroblasts .
3197586	0	PGE2	34,38	secretin	11,19	PGE2	secretin	MESH:D015232	6343	Chemical	Gene	content|nmod|START_ENTITY Effects|nmod|content Effects|nmod|END_ENTITY	Effects of secretin on content of PGE2 and 6-keto_PGF1 alpha in gastric mucosa .
6268503	0	PGE2	26,30	secretin	140,148	PGE2	secretin	MESH:D015232	6343	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of graded doses of PGE2 on pancreatic exocrine secretion of bicarbonate , chymotrypsin and cyclic_nucleotides during i.v. infusion of secretin in man .
10233013	0	PGE2	0,4	substance_P	15,26	PGE2	substance P	MESH:D015232	6863	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|release release|compound|END_ENTITY	PGE2 increases substance_P release from renal_pelvic_sensory_nerves via activation of N-type calcium channels .
10933609	0	PGE2	46,50	tumor_necrosis_factor-alpha	72,99	PGE2	tumor necrosis factor-alpha	MESH:D015232	21926(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	IFN-gamma inhibits the suppressive effects of PGE2 on the production of tumor_necrosis_factor-alpha by mouse macrophages .
22594905	0	PGE2	114,118	ulinastatin	20,31	PGE2	ulinastatin	MESH:D015232	11699(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Additive effects of ulinastatin and docetaxel on growth of breast_cancer xenograft in nude_mice and expression of PGE2 , IL-10 , and IL-2 in primary breast_cancer cells .
15995627	0	PGE2	0,4	vascular_endothelial_growth_factor	18,52	PGE2	vascular endothelial growth factor	MESH:D015232	7422	Chemical	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|compound|END_ENTITY	PGE2 up-regulates vascular_endothelial_growth_factor expression in MKN28 gastric_cancer cells via epidermal_growth_factor_receptor signaling system .
26181635	0	PGI2	19,23	Epac-1	68,74	PGI2	Epac-1	MESH:D011464	10411	Chemical	Gene	Production|compound|START_ENTITY Production|nmod|END_ENTITY	Cilostazol Induces PGI2 Production via Activation of the Downstream Epac-1 / Rap1 Signaling Cascade to Increase Intracellular Calcium by PLC and to Activate p44/42 MAPK in Human Aortic Endothelial Cells .
14600076	0	PGJ2	56,60	PPARgamma	0,9	PGJ2	PPARgamma	MESH:C037112	5468	Chemical	Gene	actions|nmod|START_ENTITY required|nmod|actions required|nsubjpass|END_ENTITY	PPARgamma is not required for the inhibitory actions of PGJ2 on cytokine signaling in pancreatic beta-cells .
14552591	0	PGP-4008	107,115	P-glycoprotein	81,95	PGP-4008	P-glycoprotein	MESH:C483891	67078(Tax:10090)	Chemical	Gene	modulator|appos|START_ENTITY modulator|amod|END_ENTITY	Development of a syngeneic in vivo tumor model and its use in evaluating a novel P-glycoprotein modulator , PGP-4008 .
21641211	0	PH-797804	13,22	p38	67,70	PH-797804	p38	MESH:C542398	1432	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|MAP MAP|amod|END_ENTITY	Discovery of PH-797804 , a highly selective and potent inhibitor of p38 MAP kinase .
22174080	0	PH-797804	46,55	p38	59,62	PH-797804	p38	MESH:C542398	1432	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Discovery and characterization of atropisomer PH-797804 , a p38 MAP kinase inhibitor , as a clinical drug candidate .
21181437	0	PH006	0,5	Src	29,32	PH006	Src	null	6714	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	PH006 , a novel and selective Src kinase inhibitor , suppresses human breast_cancer growth and metastasis in vitro and in vivo .
15788682	0	PHA665752	44,53	c-MET	27,32	PHA665752	c-MET	MESH:C480541	4233	Chemical	Gene	Inhibitor|appos|START_ENTITY Inhibitor|compound|END_ENTITY	A selective small molecule c-MET Inhibitor , PHA665752 , cooperates with rapamycin .
19939254	0	PHA665752	0,9	c-Met	41,46	PHA665752	c-Met	MESH:C480541	4233	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	PHA665752 , a small-molecule inhibitor of c-Met , inhibits hepatocyte growth factor-stimulated migration and proliferation of c-Met-positive neuroblastoma cells .
26695152	0	PHA665752	35,44	c-Met	28,33	PHA665752	c-Met	MESH:C480541	4233	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|nmod|END_ENTITY	Small molecule inhibitor of c-Met -LRB- PHA665752 -RRB- suppresses the growth of ovarian_cancer cells and reverses cisplatin resistance .
2460071	0	PHI	101,104	CGRP	58,62	PHI	CGRP	null	796	Chemical	Gene	VIP|appos|START_ENTITY VIP|appos|END_ENTITY	Immunohistochemical studies of the neurochemical markers , CGRP , enkephalin , galanin , gamma-MSH , NPY , PHI , proctolin , PTH , somatostatin , SP , VIP , tyrosine hydroxylase and neurofilament in nerves and cells of the human attached_gingiva .
2460071	0	PHI	101,104	NPY	96,99	PHI	NPY	null	4852	Chemical	Gene	VIP|appos|START_ENTITY VIP|appos|END_ENTITY	Immunohistochemical studies of the neurochemical markers , CGRP , enkephalin , galanin , gamma-MSH , NPY , PHI , proctolin , PTH , somatostatin , SP , VIP , tyrosine hydroxylase and neurofilament in nerves and cells of the human attached_gingiva .
2460071	0	PHI	101,104	PTH	117,120	PHI	PTH	null	5741	Chemical	Gene	VIP|appos|START_ENTITY VIP|appos|END_ENTITY	Immunohistochemical studies of the neurochemical markers , CGRP , enkephalin , galanin , gamma-MSH , NPY , PHI , proctolin , PTH , somatostatin , SP , VIP , tyrosine hydroxylase and neurofilament in nerves and cells of the human attached_gingiva .
1484433	0	PHI	92,95	VIP	53,56	PHI	VIP	null	100735454	Chemical	Gene	peptide|appos|START_ENTITY peptide|appos|END_ENTITY	-LSB- Inhibitory effect of vasoactive intestinal peptide -LRB- VIP -RRB- and peptide histidine_isoleucine -LRB- PHI -RRB- on bronchoconstriction in guinea_pigs -RSB- .
2983161	0	PHI	41,44	VIP	56,59	PHI	VIP	null	7432	Chemical	Gene	START_ENTITY|nmod|receptors receptors|compound|END_ENTITY	Interaction of PHM , PHI and 24-glutamine PHI with human VIP receptors from colonic epithelium : comparison with rat intestinal receptors .
2460071	0	PHI	101,104	gamma-MSH	85,94	PHI	gamma-MSH	null	5443	Chemical	Gene	VIP|appos|START_ENTITY VIP|appos|END_ENTITY	Immunohistochemical studies of the neurochemical markers , CGRP , enkephalin , galanin , gamma-MSH , NPY , PHI , proctolin , PTH , somatostatin , SP , VIP , tyrosine hydroxylase and neurofilament in nerves and cells of the human attached_gingiva .
26102743	0	PHOSPHATE	40,49	FGF23	89,94	PHOSPHATE	FGF23	D010710	170583(Tax:10116)	Chemical	Gene	BINDER|compound|START_ENTITY BINDER|nmod|FIBROBLAST_GROWTH_FACTOR_23 FIBROBLAST_GROWTH_FACTOR_23|appos|END_ENTITY	1D .08 : EFFECT OF PA21 , A NEW IRON-BASED PHOSPHATE BINDER ON FIBROBLAST_GROWTH_FACTOR_23 -LRB- FGF23 -RRB- AND VASCULAR CALCIFICATIONS IN UREMIC RATS .
18374659	0	PHSRN	58,63	HSP70	17,22	PHSRN	HSP70	null	3308	Chemical	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|END_ENTITY	Up-regulation of HSP70 by the fibronectin-derived peptide PHSRN in human corneal epithelial cells .
26643070	6	PIO	1069,1072	AMPK	1105,1109	PIO	kip1	null	1027	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	In particular , PIO at 30 M concentration activates AMPK to induce raptor phosphorylation , which diminishes PDGF-induced mTOR activity as evidenced by decreased phosphorylation of p70S6K , 4E-BP1 , and S6 and increased accumulation of p27 -LRB- kip1 -RRB- , a cell cycle inhibitor .
26754586	0	PITavastatin	185,197	ApoB-48	36,43	PITavastatin	ApoB-48	MESH:C108475	338	Chemical	Gene	Efficacy|nmod|START_ENTITY Evaluating|dobj|Efficacy Study|acl|Evaluating Sub-study|nmod|Study Effect|dep|Sub-study Effect|nmod|Treatment Treatment|nmod|END_ENTITY	Effect of Pitavastatin Treatment on ApoB-48 and Lp-PLA in Patients with Metabolic_Syndrome : Sub-study of PROspective Comparative Clinical Study Evaluating the Efficacy and Safety of PITavastatin in Patients with Metabolic_Syndrome .
19890834	0	PJ-34	31,36	PARP	14,18	PJ-34	PARP	MESH:C434926	142	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Inhibition of PARP activity by PJ-34 leads to growth impairment_and_cell_death associated with aberrant mitotic pattern and nucleolar actin accumulation in M14 melanoma cell line .
25934569	0	PJ-34	0,5	PARP-1	15,21	PJ-34	PARP-1	MESH:C434926	25591(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	PJ-34 inhibits PARP-1 expression and ERK phosphorylation in glioma-conditioned brain microvascular endothelial cells .
11179503	0	PJ34	22,26	PARP	86,90	PJ34	PARP	MESH:C434926	25591(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY _|nsubj|effects _|dobj|polymerase polymerase|appos|END_ENTITY	Protective effects of PJ34 , a novel , potent inhibitor of poly -LRB- ADP-ribose -RRB- _ polymerase -LRB- PARP -RRB- in in vitro and in vivo models of stroke .
16872633	0	PJ34	73,77	PARP	56,60	PJ34	PARP	MESH:C434926	11545(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|appos|END_ENTITY	Local administration of the Poly_ADP-Ribose Polymerase -LRB- PARP -RRB- inhibitor , PJ34 during hindlimb ischemia modulates skeletal muscle reperfusion injury .
23025350	0	PJ34	51,55	PARP	84,88	PJ34	PARP	MESH:C434926	142	Chemical	Gene	targets|nmod|START_ENTITY kinases|nmod|targets kinases|advcl|confounding confounding|nmod|biology biology|compound|END_ENTITY	Identification of pim kinases as novel targets for PJ34 with confounding effects in PARP biology .
24692719	0	PJ34	40,44	PARP	25,29	PJ34	PARP	MESH:C434926	142	Chemical	Gene	vorinostat|compound|START_ENTITY inhibitor|dobj|vorinostat inhibitor|nsubj|effects effects|nmod|END_ENTITY	Combinatorial effects of PARP inhibitor PJ34 and histone_deacetylase inhibitor vorinostat on leukemia cell lines .
25351371	0	PJ34	0,4	PARP	37,41	PJ34	PARP	MESH:C434926	142	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|appos|END_ENTITY	PJ34 , a poly -LRB- ADP-ribose -RRB- _ polymerase -LRB- PARP -RRB- inhibitor , reverses melphalan-resistance and inhibits repair of DNA double-strand breaks by targeting the FA/BRCA pathway in multidrug resistant multiple myeloma cell line RPMI8226/R .
26492236	0	PJ34	15,19	PARP	0,4	PJ34	PARP	MESH:C434926	11545(Tax:10090)	Chemical	Gene	Differentiation|compound|START_ENTITY Differentiation|compound|END_ENTITY	PARP Inhibitor PJ34 Suppresses Osteogenic Differentiation in Mouse Mesenchymal Stem Cells by Modulating BMP-2 Signaling Pathway .
17131054	0	PJ34	43,47	PARP-1	26,32	PJ34	PARP-1	MESH:C434926	142	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|effects effects|nmod|END_ENTITY	Protective effects of the PARP-1 inhibitor PJ34 in hypoxic-reoxygenated_cardiomyoblasts .
18695907	0	PJ34	0,4	PARP-1	22,28	PJ34	PARP-1	MESH:C434926	142	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	PJ34 , an inhibitor of PARP-1 , suppresses cell growth and enhances the suppressive effects of cisplatin in liver_cancer cells .
22297980	0	PJ34	73,77	tankyrase_1	19,30	PJ34	tankyrase 1	MESH:C434926	8658	Chemical	Gene	Structure|nmod|START_ENTITY Structure|nmod|END_ENTITY	Structure of human tankyrase_1 in complex with small-molecule inhibitors PJ34 and XAV939 .
15916899	0	PK11195	42,49	Peripheral_benzodiazepine_receptor	0,34	PK11195	Peripheral benzodiazepine receptor	MESH:C037850	24230(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY ligand|ccomp|reduces ligand|nsubj|END_ENTITY	Peripheral_benzodiazepine_receptor ligand PK11195 reduces microglial activation and neuronal_death in quinolinic_acid-injected rat striatum .
12382020	0	PK11195	0,7	mitochondrial_benzodiazepine_receptor	51,88	PK11195	mitochondrial benzodiazepine receptor	MESH:C037850	706	Chemical	Gene	START_ENTITY|appos|ligand ligand|nmod|END_ENTITY	PK11195 , an isoquinoline_carboxamide ligand of the mitochondrial_benzodiazepine_receptor , increased drug uptake and facilitated drug-induced apoptosis in human multidrug-resistant leukemia cells in vitro .
12730627	0	PK11195	130,137	mitochondrial_benzodiazepine_receptor	155,192	PK11195	mitochondrial benzodiazepine receptor	MESH:C037850	706	Chemical	Gene	START_ENTITY|appos|ligand ligand|nmod|END_ENTITY	Reversal of Bcl-2-mediated resistance of the EW36 human B-cell_lymphoma cell line to arsenite - and pesticide-induced apoptosis by PK11195 , a ligand of the mitochondrial_benzodiazepine_receptor .
9637784	0	PK11195	0,7	mitochondrial_benzodiazepine_receptor	25,62	PK11195	mitochondrial benzodiazepine receptor	MESH:C037850	706	Chemical	Gene	START_ENTITY|appos|ligand ligand|nmod|END_ENTITY	PK11195 , a ligand of the mitochondrial_benzodiazepine_receptor , facilitates the induction of apoptosis and reverses Bcl-2-mediated cytoprotection .
16092946	0	PK11195	57,64	peripheral_benzodiazepine_receptor	14,48	PK11195	peripheral benzodiazepine receptor	MESH:C037850	24230(Tax:10116)	Chemical	Gene	ligand|appos|START_ENTITY ligand|compound|END_ENTITY	High-affinity peripheral_benzodiazepine_receptor ligand , PK11195 , regulates protein phosphorylation in rat brain mitochondria under control of Ca -LRB- 2 + -RRB- .
23358477	0	PK11195	39,46	translocator_protein	4,24	PK11195	translocator protein	MESH:C037850	706	Chemical	Gene	induces|nsubj|START_ENTITY ligand|ccomp|induces ligand|nsubj|END_ENTITY	The translocator_protein -LRB- TSPO -RRB- ligand PK11195 induces apoptosis and cell cycle arrest and sensitizes to chemotherapy treatment in pre - and post-relapse neuroblastoma cell lines .
16091734	0	PKC412	62,68	FGFR3	0,5	PKC412	FGFR3	MESH:C411007	2261	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|END_ENTITY	FGFR3 as a therapeutic target of the small molecule inhibitor PKC412 in hematopoietic_malignancies .
12124173	0	PKC412	102,108	FLT3	21,25	PKC412	FLT3	MESH:C411007	14255(Tax:10090)	Chemical	Gene	tyrosine|dobj|START_ENTITY tyrosine|nsubj|Inhibition Inhibition|nmod|receptors receptors|compound|END_ENTITY	Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412 .
15345597	0	PKC412	132,138	FLT3	100,104	PKC412	FLT3	MESH:C411007	2322	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Patients with acute_myeloid_leukemia and an activating mutation in FLT3 respond to a small-molecule FLT3 tyrosine kinase inhibitor , PKC412 .
16150941	0	PKC412	44,50	FLT3	107,111	PKC412	FLT3	MESH:C411007	2322	Chemical	Gene	START_ENTITY|nmod|mutation mutation|nmod|Asn-676 Asn-676|nmod|domain domain|compound|END_ENTITY	Clinical resistance to the kinase inhibitor PKC412 in acute_myeloid_leukemia by mutation of Asn-676 in the FLT3 tyrosine kinase domain .
17330105	0	PKC412	31,37	FLT3	94,98	PKC412	FLT3	MESH:C411007	2322	Chemical	Gene	START_ENTITY|nmod|combination combination|nmod|agents agents|nmod|versus versus|nummod|END_ENTITY	Divergent cytotoxic effects of PKC412 in combination with conventional antileukemic agents in FLT3 mutation-positive versus - negative leukemia cell lines .
17960382	0	PKC412	19,25	FLT3	4,8	PKC412	FLT3	MESH:C411007	2322	Chemical	Gene	START_ENTITY|nsubj|inhibitor inhibitor|compound|END_ENTITY	The FLT3 inhibitor PKC412 in combination with cytostatic drugs in vitro in acute_myeloid_leukemia .
18071308	0	PKC412	19,25	FLT3	112,116	PKC412	FLT3	MESH:C411007	2322	Chemical	Gene	exerts|nsubj|START_ENTITY exerts|advcl|presence presence|nmod|mutations mutations|nummod|END_ENTITY	The FLT3 inhibitor PKC412 exerts differential cell cycle effects on leukemic cells depending on the presence of FLT3 mutations .
22225957	0	PKF275-055	11,21	dipeptidyl_peptidase-4	25,47	PKF275-055	dipeptidyl peptidase-4	MESH:C569631	13482(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effects of PKF275-055 , a dipeptidyl_peptidase-4 inhibitor , on the development of atherosclerotic_lesions in apolipoprotein_E-null mice .
21984837	0	PKF275-055	22,32	dipeptidyl_peptidase_IV	87,110	PKF275-055	dipeptidyl peptidase IV	MESH:C569631	25253(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|inhibitor inhibitor|compound|END_ENTITY	Beneficial effects of PKF275-055 , a novel , selective , orally bioavailable , long-acting dipeptidyl_peptidase_IV inhibitor in streptozotocin-induced diabetic_peripheral_neuropathy .
15699574	0	PKI-166	46,53	Her-1	30,35	PKI-166	Her-1	MESH:C410026	1956	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|END_ENTITY	Cytotoxic effect of the Her-2 / Her-1 inhibitor PKI-166 on renal_cancer cells expressing the connexin_32 gene .
20797855	0	PKI-179	0,7	PI3K	67,71	PKI-179	PI3K	MESH:C549124	5293	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|appos|END_ENTITY	PKI-179 : an orally efficacious dual phosphatidylinositol-3-kinase -LRB- PI3K -RRB- / mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitor .
20797855	0	PKI-179	0,7	mTOR	104,108	PKI-179	mTOR	MESH:C549124	21977(Tax:10090)	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|appos|END_ENTITY	PKI-179 : an orally efficacious dual phosphatidylinositol-3-kinase -LRB- PI3K -RRB- / mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitor .
20797855	0	PKI-179	0,7	mammalian_target_of_rapamycin	73,102	PKI-179	mammalian target of rapamycin	MESH:C549124	2475	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	PKI-179 : an orally efficacious dual phosphatidylinositol-3-kinase -LRB- PI3K -RRB- / mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitor .
20797855	0	PKI-179	0,7	phosphatidylinositol-3-kinase	36,65	PKI-179	phosphatidylinositol-3-kinase	MESH:C549124	5293	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	PKI-179 : an orally efficacious dual phosphatidylinositol-3-kinase -LRB- PI3K -RRB- / mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitor .
17561806	0	PK_11195	37,45	Translocator_protein	0,20	PK 11195	Translocator protein	MESH:C037850	706	Chemical	Gene	induces|nsubj|START_ENTITY ligand|ccomp|induces ligand|nsubj|END_ENTITY	Translocator_protein -LRB- 18 kDa -RRB- ligand PK_11195 induces transient mitochondrial Ca2 + release leading to transepithelial Cl - secretion in HT-29 human colon_cancer cells .
21403637	0	PLA	67,70	bmp4	56,60	PLA	bmp4	CHEBI:60159	652	Chemical	Gene	using|dobj|START_ENTITY END_ENTITY|acl|using	Detection of signaling effector-complexes downstream of bmp4 using PLA , a proximity ligation assay .
19429421	0	PLGA	39,43	ICAM-1	0,6	PLGA	ICAM-1	MESH:C043435	3383	Chemical	Gene	targeting|nmod|START_ENTITY targeting|compound|END_ENTITY	ICAM-1 targeting of doxorubicin-loaded PLGA nanoparticles to lung epithelial cells .
22414620	0	PLGA	36,40	PTH	21,24	PLGA	PTH	MESH:C043435	24694(Tax:10116)	Chemical	Gene	microspheres|compound|START_ENTITY END_ENTITY|nmod|microspheres	Sustained release of PTH -LRB- 1-34 -RRB- from PLGA microspheres suppresses_osteoarthritis progression in rats .
25437063	0	PLGA	119,123	TGF-b1	100,106	PLGA	TGF-b1	MESH:C043435	7040	Chemical	Gene	microspheres|compound|START_ENTITY END_ENTITY|nmod|microspheres	Controllable promotion of chondrocyte adhesion and growth on PVA hydrogels by controlled release of TGF-b1 from porous PLGA microspheres .
16579687	0	PLGA	35,39	TGFbeta3	21,29	PLGA	TGFbeta3	MESH:C043435	7043	Chemical	Gene	microspheres|compound|START_ENTITY END_ENTITY|nmod|microspheres	Sustained release of TGFbeta3 from PLGA microspheres and its effect on early osteogenic differentiation of human mesenchymal stem cells .
18313747	9	PLGA	1337,1341	bFGF	1326,1330	PLGA	bFGF	MESH:C043435	14173(Tax:10090)	Chemical	Gene	bound|dobj|START_ENTITY END_ENTITY|acl|bound	Mouse 3T3 fibroblasts were cultured on the bFGF bound PLGA with a prior plasma treatment -LRB- 20W , 20min -RRB- -LRB- PT-PLGA/bFGF -RRB- film , which showed that bFGF released from PT-PLGA/bFGF film was bioactive .
26181841	0	PLGA	47,51	insulin	33,40	PLGA	insulin	MESH:C043435	3630	Chemical	Gene	using|dobj|START_ENTITY END_ENTITY|acl|using	Enhanced oral bioavailability of insulin using PLGA nanoparticles co-modified with cell-penetrating peptides and Engrailed secretion peptide -LRB- Sec -RRB- .
20827713	0	PLLA	62,66	growth_factor	35,48	PLLA	growth factor	CHEBI:53408	79215(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY release|compound|END_ENTITY	Effect of nanotubes and apatite on growth_factor release from PLLA scaffolds .
21295875	0	PLX-4032	131,139	B-RAF	120,125	PLX-4032	B-RAF	MESH:C551177	673	Chemical	Gene	radiosensitized|nmod|START_ENTITY radiosensitized|nmod|inhibition inhibition|nmod|END_ENTITY	Melanoma cells show a heterogeneous range of sensitivity to ionizing radiation and are radiosensitized by inhibition of B-RAF with PLX-4032 .
20496265	0	PLX-4032	0,8	B-Raf	27,32	PLX-4032	B-Raf	MESH:C551177	673	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	PLX-4032 , a small-molecule B-Raf inhibitor for the potential treatment of malignant_melanoma .
25847190	0	PLX3397	122,129	FLT3	84,88	PLX3397	FLT3	null	2322	Chemical	Gene	Mutation|nmod|START_ENTITY Mutation|compound|END_ENTITY	Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 `` Gatekeeper '' F691L Mutation with PLX3397 .
18458053	0	PLX4032	60,67	BRAF	0,4	PLX4032	BRAF	MESH:C551177	673	Chemical	Gene	silencing|nmod|START_ENTITY END_ENTITY|acl|silencing	BRAF silencing by short hairpin RNA or chemical blockade by PLX4032 leads to different responses in melanoma and thyroid_carcinoma cells .
20149136	0	PLX4032	0,7	BRAF	21,25	PLX4032	BRAF	MESH:C551177	673	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	PLX4032 , a selective BRAF -LRB- V600E -RRB- kinase inhibitor , activates the ERK pathway and enhances cell migration and proliferation of BRAF melanoma cells .
20689758	0	PLX4032	95,102	BRAF	74,78	PLX4032	BRAF	MESH:C551177	673	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Pharmacodynamic characterization of the efficacy signals due to selective BRAF inhibition with PLX4032 in malignant_melanoma .
21609436	2	PLX4032	456,463	BRAF	549,553	PLX4032	LKB1	MESH:C551177	6794	Chemical	Gene	vemurafenib|appos|START_ENTITY combination|nmod|vemurafenib tested|nsubjpass|combination tested|nmod|END_ENTITY	MATERIALS AND METHODS : The combination of the BRAF inhibitor vemurafenib -LRB- formerly PLX4032 -RRB- and metformin were tested against a panel of human melanoma cell lines with defined BRAF and NRAS mutations for effects on viability , cell cycle and apoptosis .
22028422	0	PLX4032	13,20	BRAF	64,68	PLX4032	BRAF	MESH:C551177	673	Chemical	Gene	Vemurafenib|appos|START_ENTITY Vemurafenib|dep|inhibitor inhibitor|nmod|END_ENTITY	Vemurafenib -LRB- PLX4032 -RRB- : an orally available inhibitor of mutated BRAF for the treatment of metastatic_melanoma .
22454535	0	PLX4032	144,151	BRAF	115,119	PLX4032	BRAF	MESH:C551177	109880(Tax:10090)	Chemical	Gene	vemurafenib|appos|START_ENTITY Impact|dep|vemurafenib Impact|nmod|distribution distribution|nmod|inhibitor inhibitor|compound|END_ENTITY	Impact of P-glycoprotein -LRB- ABCB1 -RRB- and breast_cancer_resistance_protein -LRB- ABCG2 -RRB- on the brain distribution of a novel BRAF inhibitor : vemurafenib -LRB- PLX4032 -RRB- .
22646766	0	PLX4032	22,29	BRAF	52,56	PLX4032	BRAF	MESH:C551177	673	Chemical	Gene	RG67204|dep|START_ENTITY Vemurafenib|appos|RG67204 Vemurafenib|dep|inhibitor inhibitor|nummod|END_ENTITY	Vemurafenib -LRB- RG67204 , PLX4032 -RRB- : a potent , selective BRAF kinase inhibitor .
24460976	0	PLX4032	68,75	BRaf	16,20	PLX4032	BRaf	MESH:C551177	109880(Tax:10090)	Chemical	Gene	melanoma|nmod|START_ENTITY melanoma|nsubj|END_ENTITY	Multiple murine BRaf -LRB- V600E -RRB- melanoma cell lines with sensitivity to PLX4032 .
26347528	0	PLX_4720	58,66	B-Raf	0,5	PLX 4720	B-Raf	MESH:C528407	673	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	B-Raf inhibition in conjunctival_melanoma cell lines with PLX_4720 .
26347528	0	PLX_4720	58,66	B-Raf	0,5	PLX 4720	B-Raf	MESH:C528407	673	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	B-Raf inhibition in conjunctival_melanoma cell lines with PLX_4720 .
20634973	0	PLZF	44,48	a-actin	14,21	PLZF	a-actin	null	421534(Tax:9031)	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Smooth muscle a-actin is a direct target of PLZF : effects on the cytoskeleton and on susceptibility to oncogenic transformation .
19388146	0	PMA	56,59	CD147	14,19	PMA	CD147	CHEBI:60755	682	Chemical	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of CD147 on phorbol-12-myristate-13-acetate -LRB- PMA -RRB- - treated U937 cells differentiating into foam cells .
22206674	0	PMA	0,3	GCMa	12,16	PMA	GCMa	CHEBI:60755	8521	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|compound|END_ENTITY	PMA induces GCMa phosphorylation and alters its stability via the PKC - and ERK-dependent pathway .
23238746	0	PMA	17,20	ICAM-1	43,49	PMA	ICAM-1	CHEBI:60755	3383	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	SIRT1 suppresses PMA and ionomycin-induced ICAM-1 expression in endothelial cells .
18472849	0	PMA	118,121	Interleukin-6	0,13	PMA	Interleukin-6	CHEBI:60755	3569	Chemical	Gene	effect|nmod|START_ENTITY secretion|dep|effect secretion|amod|END_ENTITY	Interleukin-6 and interleukin-6_receptor secretion by chronic_lymphatic_leukaemia and normal B lymphocytes : effect of PMA and PWM .
9049971	0	PMA	14,17	MPL	68,71	PMA	MPL	CHEBI:60755	4352	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Phorbol_ester PMA induces expression of the thrombopoietin receptor MPL in leukemia cells .
16464174	0	PMA	67,70	NHE3	41,45	PMA	NHE3	CHEBI:60755	6550	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Transcriptional stimulation of the human NHE3 promoter activity by PMA : PKC independence and involvement of the transcription factor EGR-1 .
18212353	0	PMA	33,36	PTGS2	40,45	PMA	PTGS2	CHEBI:60755	5743	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Opposite effect of phorbol_ester PMA on PTGS2 and PGDH mRNA expression in human chorion trophoblast cells .
17464217	0	PMA	0,3	Stat3	14,19	PMA	Stat3	CHEBI:60755	25125(Tax:10116)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	PMA activates Stat3 in the Jak/Stat pathway and induces SOCS5 in rat brain astrocytes .
16202431	7	PMA	1046,1049	TEM7	1059,1063	PMA	TEM7	CHEBI:60755	72324(Tax:10090)	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	In contrast , stimulation of endothelial cell capillary morphogenesis with PMA enhanced TEM7 expression .
1704137	7	PMA	1219,1222	TNF-alpha	1249,1258	PMA	TNF-alpha	CHEBI:60755	7124	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Although PMA induces the expression of TNF-alpha in U1 cells , the suppressive effect of GSH , GSE , and NAC on PMA-induced HIV expression in U1 cells was not associated with the inhibition of TNF-alpha expression .
7801724	0	PMA	82,85	TNF-alpha	13,22	PMA	TNF-alpha	CHEBI:60755	7124	Chemical	Gene	-RSB-|compound|START_ENTITY induced|nmod|-RSB- induced|csubj|-LSB- -LSB-|dobj|role role|nmod|END_ENTITY	-LSB- The role of TNF-alpha in the growth and differentiation of U937 cells induced by PMA and IFN-gamma -RSB- .
9397948	12	PMA	1574,1577	VDR	1597,1600	PMA	VDR	CHEBI:60755	24873(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|compound|END_ENTITY	Scatchard analysis demonstrated that the synergistic effect of PMA and 1,25 -LRB- OH -RRB- 2D3 on VDR protein expression was not associated with any change in the affinity of VDR for 1,25 -LRB- OH -RRB- 2D3 .
18295514	0	PMA	72,75	c-mpl	39,44	PMA	c-mpl	CHEBI:60755	4352	Chemical	Gene	induced|nmod|START_ENTITY expression|acl|induced expression|amod|END_ENTITY	Promoter regulatory motifs involved in c-mpl gene expression induced by PMA .
10564110	0	PMA	66,69	mucin	13,18	PMA	mucin	CHEBI:60755	100508689	Chemical	Gene	lines|nmod|START_ENTITY expression|nmod|lines expression|compound|END_ENTITY	Induction of mucin gene expression in human colonic cell lines by PMA is dependent on PKC-epsilon .
15533438	0	PMA	0,3	mucin	35,40	PMA	mucin	CHEBI:60755	100508689	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	PMA induces the MUC5AC respiratory mucin in human bronchial epithelial cells , via PKC , EGF/TGF-alpha , Ras/Raf , MEK , ERK and Sp1-dependent mechanisms .
11162506	0	PMA	47,50	p21	29,32	PMA	p21	CHEBI:60755	1026	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	p53-independent elevation of p21 expression by PMA results from PKC-mediated mRNA stabilization .
23827230	3	PMA	552,555	p21	617,620	PMA	p21	CHEBI:60755	24525(Tax:10116)	Chemical	Gene	interferes|nsubj|START_ENTITY interferes|dobj|p53 p53|nummod|END_ENTITY	The aim of this work was to analyze how PMA interferes in the levels of cell cycle control proteins p53 , p21 and cyclin_D1 and also to investigate its influence on M3 receptor levels .
9674706	0	PMA	75,78	urokinase-type_plasminogen_activator_receptor	15,60	PMA	urokinase-type plasminogen activator receptor	CHEBI:60755	5329	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Stimulation of urokinase-type_plasminogen_activator_receptor expression by PMA requires JNK1-dependent and - independent signaling modules .
19323627	11	PMEA	1547,1551	MDR1	1511,1515	PMEA	MDR1	null	5243	Chemical	Gene	efflux|compound|START_ENTITY contribute|nmod|efflux contribute|nsubj|END_ENTITY	MDR1 and MRP2 did not contribute to PMEA efflux .
217216	0	PMN	54,57	Myeloperoxidase	0,15	PMN	Myeloperoxidase	null	4353	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Myeloperoxidase activity and bactericidal function of PMN in iron_deficiency .
11036039	0	PMS-601	0,7	platelet-activating_factor_receptor	15,50	PMS-601	platelet-activating factor receptor	MESH:C410215	5724	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	PMS-601 , a new platelet-activating_factor_receptor antagonist that inhibits human_immunodeficiency_virus replication and potentiates zidovudine activity in macrophages .
16426477	0	PMS777	27,33	AChE	41,45	PMS777	AChE	MESH:C507206	11423(Tax:10090)	Chemical	Gene	profile|nmod|START_ENTITY profile|appos|inhibitor inhibitor|compound|END_ENTITY	Pharmacological profile of PMS777 , a new AChE inhibitor with PAF antagonistic activity .
21441599	0	PMX-53	0,6	CD88	17,21	PMX-53	CD88	MESH:C438957	728	Chemical	Gene	START_ENTITY|nmod|antagonist antagonist|compound|END_ENTITY	PMX-53 as a dual CD88 antagonist and an agonist for Mas-related_gene_2 -LRB- MrgX2 -RRB- in human mast cells .
17572693	0	PMX464	56,62	thioredoxin	75,86	PMX464	thioredoxin	MESH:C554438	7295	Chemical	Gene	action|nmod|START_ENTITY investigation|nmod|action investigation|appos|inhibitor inhibitor|compound|END_ENTITY	A cellular and molecular investigation of the action of PMX464 , a putative thioredoxin inhibitor , in normal and colorectal_cancer cell lines .
18587424	0	PMX464	0,6	thioredoxin	45,56	PMX464	thioredoxin	MESH:C554438	7295	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	PMX464 , a thiol-reactive quinol and putative thioredoxin inhibitor , inhibits NF-kappaB-dependent proinflammatory activation of alveolar epithelial cells .
20234191	0	PND-1186	0,8	FAK	9,12	PND-1186	FAK	MESH:C559284	14083(Tax:10090)	Chemical	Gene	inhibitor|compound|START_ENTITY inhibitor|compound|END_ENTITY	PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments .
20234193	0	PND-1186	17,25	FAK	26,29	PND-1186	FAK	MESH:C559284	14083(Tax:10090)	Chemical	Gene	inhibitor|compound|START_ENTITY inhibitor|compound|END_ENTITY	Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models .
24063218	0	PNS	11,14	BACE1	46,51	PNS	BACE1	null	23821(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|nmod|END_ENTITY	-LSB- Effect of PNS on the activity and content of BACE1 in the brain of SAMP8 mice with Alzheimer 's _ disease -RSB- .
10989267	0	PNU-101387G	47,58	dopamine_D4_receptor	14,34	PNU-101387G	dopamine D4 receptor	MESH:C100448	1815	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	The selective dopamine_D4_receptor antagonist , PNU-101387G , prevents stress-induced cognitive_deficits in monkeys .
10543315	0	PNU-142633F	61,72	5-HT1D	45,51	PNU-142633F	5-HT1D	MESH:C401885	3352	Chemical	Gene	agonist|appos|START_ENTITY agonist|nummod|END_ENTITY	Pharmacokinetics and tolerability of a novel 5-HT1D agonist , PNU-142633F .
20728474	0	PNU-282987	22,32	alpha7_nicotinic_receptor	37,62	PNU-282987	alpha7 nicotinic receptor	MESH:C498513	11441(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Behavioral effects of PNU-282987 , an alpha7_nicotinic_receptor agonist , in mice .
23566346	0	PNU-282987	29,39	alpha7_nicotinic_receptor	44,69	PNU-282987	alpha7 nicotinic receptor	MESH:C498513	11441(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Motor and anxiety effects of PNU-282987 , an alpha7_nicotinic_receptor agonist , and stress in an animal model of Alzheimer 's _ disease .
16531124	0	PO4	8,11	SLC20A1	26,33	PO4	SLC20A1	null	398846(Tax:8355)	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	The Na + / PO4 cotransporter SLC20A1 gene labels distinct restricted subdomains of the developing pronephros in Xenopus and zebrafish embryos .
12777712	0	PO4	85,88	polymerase_beta	4,19	PO4	polymerase beta	null	29240(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|dep|effects	Rat polymerase_beta gapped DNA interactions : antagonistic effects of the 5 ' terminal PO4 - group and magnesium on the enzyme binding to the gapped DNAs with different ssDNA gaps .
1811059	0	POCA	81,85	carnitine_palmitoyltransferase_I	89,121	POCA	carnitine palmitoyltransferase I	MESH:C033891	25756(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Fatty_acid accumulation during ischemia and reperfusion : effects of pyruvate and POCA , a carnitine_palmitoyltransferase_I inhibitor .
26360610	0	POL5551	0,7	CXCR4	28,33	POL5551	CXCR4	null	7852	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	POL5551 , a novel and potent CXCR4 antagonist , enhances sensitivity to chemotherapy in pediatric_ALL .
26112287	0	POL7085	65,72	CCR10	47,52	POL7085	CCR10	null	12777(Tax:10090)	Chemical	Gene	effect|amod|START_ENTITY effect|nmod|END_ENTITY	Protective effect of a Protein Epitope Mimetic CCR10 antagonist , POL7085 , in a model of allergic eosinophilic airway_inflammation .
1911831	0	POPC	51,55	melittin	20,28	POPC	melittin	MESH:C065191	406130(Tax:7460)	Chemical	Gene	interaction|nmod|START_ENTITY END_ENTITY|nmod|interaction	Effective charge of melittin upon interaction with POPC vesicles .
17556100	0	PP2	0,3	Src	27,30	PP2	Src	CHEBI:33479	83805(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|kinases kinases|compound|END_ENTITY	PP2 , a potent inhibitor of Src family kinases , protects against hippocampal CA1 pyramidal cell death after transient global brain_ischemia .
23991179	6	PP242	1114,1119	mTORC2	1234,1240	PP242	mTORC2	MESH:C572919	74343(Tax:10090)	Chemical	Gene	treatment|compound|START_ENTITY cells|nmod|treatment increase|nmod|cells raised|nsubj|increase raised|ccomp|contribute contribute|nmod|inhibition inhibition|nmod|END_ENTITY	The parallel increase of AKT -LRB- S473 -RRB- and EGFR -LRB- T1068 -RRB- in the cells following PP242 treatment raised the possibility that EGFR phosphorylation might contribute to the PP242 incomplete inhibition of mTORC2 .
23991179	6	PP242	1203,1208	mTORC2	1234,1240	PP242	mTORC2	MESH:C572919	74343(Tax:10090)	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	The parallel increase of AKT -LRB- S473 -RRB- and EGFR -LRB- T1068 -RRB- in the cells following PP242 treatment raised the possibility that EGFR phosphorylation might contribute to the PP242 incomplete inhibition of mTORC2 .
25568665	0	PP242	110,115	mTORC2	0,6	PP242	mTORC2	MESH:C572919	74343(Tax:10090)	Chemical	Gene	confer|nmod|START_ENTITY modulates|xcomp|confer modulates|nsubj|END_ENTITY	mTORC2 modulates feedback regulation of p38 MAPK activity via DUSP10/MKP5 to confer differential responses to PP242 in glioblastoma .
781770	2	PPD	90,93	LIF	67,70	PPD	LIF	MESH:D014373	3976	Chemical	Gene	dose|nmod|START_ENTITY END_ENTITY|nmod|dose	In vitro production of LIF with a low dose of PPD -RSB- .
15249666	0	PPI-2458	41,49	methionine_aminopeptidase-2	2,29	PPI-2458	methionine aminopeptidase-2	MESH:C488724	10988	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	A methionine_aminopeptidase-2 inhibitor , PPI-2458 , for the treatment of rheumatoid_arthritis .
16638869	0	PPI-2458	47,55	methionine_aminopeptidase-2	8,35	PPI-2458	methionine aminopeptidase-2	MESH:C488724	10988	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	A novel methionine_aminopeptidase-2 inhibitor , PPI-2458 , inhibits non-Hodgkin 's _ lymphoma cell proliferation in vitro and in vivo .
23355637	0	PPI-2458	15,23	methionine_aminopeptidase-2	64,91	PPI-2458	methionine aminopeptidase-2	MESH:C488724	10988	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Metabolites of PPI-2458 , a selective , irreversible inhibitor of methionine_aminopeptidase-2 : structure determination and in vivo activity .
16166596	0	PPP	61,64	IGF-1	0,5	PPP	IGF-1	null	3479	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	IGF-1 receptor_tyrosine_kinase inhibition by the cyclolignan PPP induces G2/M-phase accumulation and apoptosis in multiple_myeloma cells .
16166596	0	PPP	61,64	receptor_tyrosine_kinase	6,30	PPP	receptor tyrosine kinase	null	5979	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	IGF-1 receptor_tyrosine_kinase inhibition by the cyclolignan PPP induces G2/M-phase accumulation and apoptosis in multiple_myeloma cells .
25971682	0	PQ401	0,5	IGF-1R	10,16	PQ401	IGF-1R	MESH:C569479	3480	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	PQ401 , an IGF-1R inhibitor , induces apoptosis and inhibits growth , proliferation and migration of glioma cells .
11320669	0	PR-350	11,17	dihydropyrimidine_dehydrogenase	57,88	PR-350	dihydropyrimidine dehydrogenase	MESH:C106738	81656(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|amod|END_ENTITY	Effects of PR-350 , a newly developed radiosensitizer , on dihydropyrimidine_dehydrogenase activity and 5-fluorouracil pharmacokinetics .
9786902	0	PR-39	0,5	p130	68,72	PR-39	p130	MESH:C072212	9221	Chemical	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	PR-39 , a syndecan-inducing antimicrobial peptide , binds and affects p130 -LRB- Cas -RRB- .
22797782	0	PR39	140,144	Stat3	103,108	PR39	Stat3	MESH:C072212	6774	Chemical	Gene	Suppression|nmod|START_ENTITY Suppression|nmod|END_ENTITY	Suppression of tumor invasion and migration in breast_cancer cells following delivery of siRNA against Stat3 with the antimicrobial peptide PR39 .
24141020	0	PRE-084	62,69	Sigma-1_receptor	31,47	PRE-084	Sigma-1 receptor	MESH:C071738	18391(Tax:10090)	Chemical	Gene	agonist|xcomp|START_ENTITY agonist|nsubj|effects effects|nmod|END_ENTITY	Neuroprotective effects of the Sigma-1_receptor -LRB- S1R -RRB- agonist PRE-084 , in a mouse model of motor_neuron_disease not linked to SOD1 mutation .
20081254	0	PRE-084	30,37	sigma1_receptor	51,66	PRE-084	sigma1 receptor	MESH:C071738	18391(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Antidepressant-like effect of PRE-084 , a selective sigma1_receptor agonist , in Albino Swiss and C57BL/6J mice .
17220548	0	PRI-2191	91,99	PI3-K	15,20	PRI-2191	PI3-K	MESH:C023850	5293	Chemical	Gene	Involvement|dep|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of PI3-K in neuroprotective effects of the 1,25-dihydroxyvitamin _ D3 analogue - PRI-2191 .
10499878	0	PRL-2903	119,127	somatostatin	17,29	PRL-2903	somatostatin	MESH:C121568	24797(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY reversal|nmod|antagonist inhibition|dep|reversal inhibition|compound|END_ENTITY	Urethane-induced somatostatin mediated inhibition of gastric_acid : reversal by the somatostatin 2 receptor antagonist , PRL-2903 .
10499878	0	PRL-2903	119,127	somatostatin	83,95	PRL-2903	somatostatin	MESH:C121568	24797(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	Urethane-induced somatostatin mediated inhibition of gastric_acid : reversal by the somatostatin 2 receptor antagonist , PRL-2903 .
21088136	0	PRT-060318	0,10	Syk	20,23	PRT-060318	Syk	MESH:C569036	20963(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	PRT-060318 , a novel Syk inhibitor , prevents heparin-induced thrombocytopenia and thrombosis in a transgenic mouse model .
17263189	0	PRX-00023	17,26	5-HT1A_receptor	40,55	PRX-00023	5-HT1A receptor	MESH:C511631	3350	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Drug evaluation : PRX-00023 , a selective 5-HT1A_receptor agonist for depression .
12492117	0	PS-341	0,6	Bcl-2	46,51	PS-341	Bcl-2	MESH:C400082	596	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|compound|END_ENTITY	PS-341 , a novel proteasome inhibitor , induces Bcl-2 phosphorylation and cleavage in association with G2-M phase arrest and apoptosis .
12902978	0	PS-341	25,31	TRAIL	42,47	PS-341	TRAIL	MESH:C400082	8743	Chemical	Gene	overcomes|nsubj|START_ENTITY overcomes|dobj|resistance resistance|amod|END_ENTITY	The proteasome inhibitor PS-341 overcomes TRAIL resistance in Bax and caspase_9-negative or Bcl-xL overexpressing cells .
11350913	0	PS-341	27,33	nuclear_factor-kappa_B	57,79	PS-341	nuclear factor-kappa B	MESH:C400082	18033(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	Novel proteasome inhibitor PS-341 inhibits activation of nuclear_factor-kappa_B , cell survival , tumor growth , and angiogenesis in squamous_cell_carcinoma .
11769472	0	PSA	38,41	Prostate_specific_antigen	1,26	PSA	Prostate specific antigen	null	354	Chemical	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	-LSB- Prostate_specific_antigen : a role of PSA in the diagnosis of prostate_cancer -RSB- .
24462745	0	PSB-071	79,86	NTPDase2	21,29	PSB-071	NTPDase2	null	954	Chemical	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Crystal structure of NTPDase2 in complex with the sulfoanthraquinone inhibitor PSB-071 .
19763573	0	PSC833	0,6	MDR1	45,49	PSC833	MDR1	MESH:C070272	5243	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|compound|END_ENTITY	PSC833 , cyclosporine analogue , downregulates MDR1 expression by activating JNK/c-Jun/AP -1 and suppressing NF-kappaB .
12822513	0	PSC833	95,101	p-glycoprotein	69,83	PSC833	p-glycoprotein	MESH:C070272	5243	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Combined treatment of Bcl-2 antisense oligodeoxynucleotides -LRB- G3139 -RRB- , p-glycoprotein inhibitor -LRB- PSC833 -RRB- , and sterically stabilized liposomal doxorubicin suppresses growth of drug-resistant growth of drug-resistant_breast_cancer in severely combined immunodeficient mice .
10784624	0	PSC_833	36,43	P-Glycoprotein	0,14	PSC 833	P-Glycoprotein	MESH:C070272	5243	Chemical	Gene	valspodar|appos|START_ENTITY valspodar|amod|END_ENTITY	P-Glycoprotein inhibitor valspodar -LRB- PSC_833 -RRB- increases the intracellular concentrations of daunorubicin in vivo in patients with P-glycoprotein-positive acute_myeloid_leukemia .
10348798	0	PSC_833	10,17	P-glycoprotein	21,35	PSC 833	P-glycoprotein	MESH:C070272	287115(Tax:10116)	Chemical	Gene	START_ENTITY|appos|modulator modulator|amod|END_ENTITY	Effect of PSC_833 , a P-glycoprotein modulator , on the disposition of vincristine and digoxin in rats .
10737718	0	PSC_833	4,11	P-glycoprotein	108,122	PSC 833	P-glycoprotein	MESH:C070272	5243	Chemical	Gene	activates|nsubj|START_ENTITY activates|nmod|independent independent|nmod|END_ENTITY	SDZ PSC_833 the drug resistance modulator activates cellular ceramide formation by a pathway independent of P-glycoprotein .
12893426	0	PSC_833	10,17	P-glycoprotein	41,55	PSC 833	P-glycoprotein	MESH:C070272	5243	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|inhibitor inhibitor|nmod|END_ENTITY	Effect of PSC_833 , a potent inhibitor of P-glycoprotein , on the growth of astrocytoma cells in vitro .
12970066	0	PSC_833	10,17	P-glycoprotein	35,49	PSC 833	P-glycoprotein	MESH:C070272	287115(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|inhibitor inhibitor|nmod|END_ENTITY	Effect of PSC_833 , an inhibitor of P-glycoprotein , on 1,2-dimethylhydrazine-induced liver_carcinogenesis in rats .
14633655	0	PSC_833	10,17	P-glycoprotein	35,49	PSC 833	P-glycoprotein	MESH:C070272	287115(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Effect of PSC_833 , an inhibitor of P-glycoprotein on N-methyl-N-nitrosourea induced mammary carcinogenesis in rats .
15269145	0	PSC_833	91,98	P-glycoprotein	54,68	PSC 833	P-glycoprotein	MESH:C070272	5243	Chemical	Gene	study|appos|START_ENTITY study|nmod|vinblastine vinblastine|nmod|valspodar valspodar|amod|END_ENTITY	A phase I/II study of infusional vinblastine with the P-glycoprotein antagonist valspodar -LRB- PSC_833 -RRB- in renal_cell_carcinoma .
16619498	0	PSC_833	0,7	P-glycoprotein	25,39	PSC 833	P-glycoprotein	MESH:C070272	287115(Tax:10116)	Chemical	Gene	inhibits|advmod|START_ENTITY inhibits|nsubj|inhibitor inhibitor|nmod|END_ENTITY	PSC_833 , an inhibitor of P-glycoprotein inhibits 1,2-dimethylhydrazine-induced colorectal_carcinogenesis in male Fischer F344 rats .
9055138	0	PSC_833	48,55	P-glycoprotein	59,73	PSC 833	P-glycoprotein	MESH:C070272	5243	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Initial pharmacokinetics and bioavailability of PSC_833 , a P-glycoprotein antagonist .
9415704	0	PSC_833	60,67	P-glycoprotein	115,129	PSC 833	P-glycoprotein	MESH:C070272	5243	Chemical	Gene	bisacridone|nmod|START_ENTITY Characterization|nmod|bisacridone Characterization|nmod|modulator modulator|nmod|END_ENTITY	Characterization of a novel bisacridone and comparison with PSC_833 as a potent and poorly reversible modulator of P-glycoprotein .
9815718	0	PSC_833	50,57	P-glycoprotein	21,35	PSC 833	P-glycoprotein	MESH:C070272	5243	Chemical	Gene	using|nsubj|START_ENTITY inhibition|advcl|using inhibition|nsubj|Detection Detection|nmod|END_ENTITY	Detection of in vivo P-glycoprotein inhibition by PSC_833 using Tc-99m sestamibi .
18024786	0	PSI-697	51,58	P-selectin	30,40	PSI-697	P-selectin	MESH:C514191	6403	Chemical	Gene	START_ENTITY|nsubj|Characterization Characterization|nmod|inhibitor inhibitor|amod|END_ENTITY	Characterization of the novel P-selectin inhibitor PSI-697 -LSB- 2 - -LRB- 4-chlorobenzyl -RRB- -3 - hydroxy-7 ,8,9,10 - tetrahydrobenzo -LSB- h -RSB- _ quinoline-4-carboxylic_acid -RSB- in vitro and in rodent models of vascular_inflammation and thrombosis .
23525448	0	PSI-697	10,17	P-selectin	27,37	PSI-697	P-selectin	MESH:C514191	6403	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effect of PSI-697 , a novel P-selectin inhibitor , on platelet-monocyte aggregate formation in humans .
17458184	0	PSN-9301	17,25	dipeptidyl_peptidase_IV	55,78	PSN-9301	dipeptidyl peptidase IV	null	1803	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Drug evaluation : PSN-9301 , a short-acting inhibitor of dipeptidyl_peptidase_IV .
15289357	0	PT-100	0,6	dipeptidyl_peptidase	25,45	PT-100	dipeptidyl peptidase	MESH:C514044	11421(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	PT-100 , a small molecule dipeptidyl_peptidase inhibitor , has potent antitumor effects and augments antibody-mediated cytotoxicity via a novel immune mechanism .
6361008	7	PTA	888,891	GPA	907,910	PTA	GPA	CHEBI:61432	2993	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	However , PTA derivatives of GPA and Arg were hydrolyzed with kcat/Km values smaller than those of N_alpha-benzoyl_ethyl_esters of L-GPA and L-Arg by factors of 4 and 17 , respectively .
15792359	0	PTCA	105,109	secretory_phospholipase_A2_type_IIA	25,60	PTCA	secretory phospholipase A2 type IIA	null	5320	Chemical	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	The catalytically active secretory_phospholipase_A2_type_IIA is involved in restenosis development after PTCA in human coronary arteries and generation of atherogenic LDL .
10850529	0	PTCA	70,74	smooth_muscle_myosin_heavy_chain	20,52	PTCA	smooth muscle myosin heavy chain	null	4629	Chemical	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	Intracoronary serum smooth_muscle_myosin_heavy_chain levels following PTCA may predict restenosis .
20561409	0	PTK787	12,18	fak	59,62	PTK787	fak	MESH:C404768	5747	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|mRNA mRNA|compound|END_ENTITY	-LSB- Effects of PTK787 on cell proliferation and expression of fak mRNA in K562 -RSB- .
20629314	0	PTU	11,14	TPO	44,47	PTU	TPO	null	54314(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of PTU on the expression of thyroid TPO , Tg mRNA in rats -RSB- .
23123171	0	PU-H71	27,33	HSP90	10,15	PU-H71	HSP90	MESH:C526550	3320	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	The novel HSP90 inhibitor , PU-H71 , suppresses glial cell activation but weakly affects clinical signs of EAE .
24388362	0	PU-H71	25,31	HSP90	41,46	PU-H71	HSP90	MESH:C526550	104434(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Pre-clinical efficacy of PU-H71 , a novel HSP90 inhibitor , alone and in combination with bortezomib in Ewing_sarcoma .
23485394	0	PU-H71	20,26	Hsp90	0,5	PU-H71	Hsp90	MESH:C526550	3320	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Hsp90 inhibition by PU-H71 induces apoptosis through endoplasmic reticulum stress and mitochondrial pathway in cancer cells and overcomes the resistance conferred by Bcl-2 .
23616796	0	PU-H71	56,62	Hsp90	84,89	PU-H71	Hsp90	MESH:C526550	3320	Chemical	Gene	derivatives|compound|START_ENTITY biotinylated|dobj|derivatives biotinylated|nmod|probes probes|compound|END_ENTITY	Synthesis and evaluation of cell-permeable biotinylated PU-H71 derivatives as tumor Hsp90 probes .
24366006	0	PU-H71	92,98	Hsp90	75,80	PU-H71	Hsp90	MESH:C526550	3320	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Radiosensitization of human lung_cancer cells by the novel purine-scaffold Hsp90 inhibitor , PU-H71 .
26117427	0	PU-H71	0,6	Hsp90	58,63	PU-H71	Hsp90	MESH:C526550	3320	Chemical	Gene	START_ENTITY|dep|improvement improvement|nmod|addiction addiction|amod|END_ENTITY	PU-H71 : An improvement on nature 's solutions to oncogenic Hsp90 addiction .
24114662	0	PU-H71	0,6	TNF-a	74,79	PU-H71	TNF-a	MESH:C526550	7124	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|presence presence|nmod|END_ENTITY	PU-H71 effectively induces degradation of IkB kinase b in the presence of TNF-a .
15217612	0	PU24FCl	50,57	Hsp90	89,94	PU24FCl	Hsp90	null	3320	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Targeting wide-range oncogenic transformation via PU24FCl , a specific inhibitor of tumor Hsp90 .
12056596	0	PUFA	52,56	C20-22	45,51	PUFA	C20-22	CHEBI:26208	1036112(Tax:199310)	Chemical	Gene	composition|compound|START_ENTITY composition|compound|END_ENTITY	A convenient method for determination of the C20-22 PUFA composition of glycerolipids in blood and breast milk .
24019303	0	PUFA	15,19	CD4	27,30	PUFA	CD4	CHEBI:26208	12504(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|type type|compound|END_ENTITY	Effects of n-3 PUFA on the CD4 type 2 helper T-cell-mediated immune responses in Fat-1 mice .
22131549	0	PUFA	81,85	Fat-1	89,94	PUFA	Fat-1	CHEBI:26208	14107(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|compound|END_ENTITY	Th17 cell accumulation is decreased during chronic experimental colitis by -LRB- n-3 -RRB- PUFA in Fat-1 mice .
8602457	6	PUFAS	1124,1129	IL-2	1146,1150	PUFAS	CD25	CHEBI:26208	3559	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|END_ENTITY	On the other hand , the authors showed that PUFAS did not inhibit IL-2 stimulated lymphocyte proliferation .
21609458	0	PUFAs	85,90	Leptin	18,24	PUFAs	Leptin	CHEBI:26208	16846(Tax:10090)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|Expression Expression|compound|END_ENTITY	The Regulation of Leptin , Leptin_Receptor and Pro-opiomelanocortin Expression by N-3 PUFAs in Diet-Induced Obese Mice Is Not Related to the Methylation of Their Promoters .
15358633	0	PUFAs	4,9	VEGF	17,21	PUFAs	VEGF	CHEBI:26208	7422	Chemical	Gene	reduce|nsubj|START_ENTITY reduce|dobj|expression expression|amod|END_ENTITY	n-3 PUFAs reduce VEGF expression in human colon_cancer cells modulating the COX-2 / PGE2 induced ERK-1_and _ -2 and HIF-1alpha induction pathway .
16000877	0	PUGNAc	43,49	IRS-1	25,30	PUGNAc	IRS-1	MESH:C068836	25467(Tax:10116)	Chemical	Gene	modification|nmod|START_ENTITY modification|nmod|END_ENTITY	O-GlcNAc modification on IRS-1 and Akt2 by PUGNAc inhibits their phosphorylation and induces insulin resistance in rat primary adipocytes .
11705733	0	PUVA	0,4	whn	19,22	PUVA	whn	null	15218(Tax:10090)	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|compound|END_ENTITY	PUVA downregulates whn expression in primary mouse keratinocytes .
17578887	8	PVN	1432,1435	CRFR1	1408,1413	PVN	CRFR1	null	58959(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nummod|END_ENTITY	In contrast CRFR1 inhibition in the PVN blunted corticosterone but not epinephrine or glucagon CRR to hypoglycemia .
21069338	0	PX-12	16,21	HIF-1a	31,37	PX-12	HIF-1a	null	3091	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|levels levels|compound|END_ENTITY	Antitumor agent PX-12 inhibits HIF-1a protein levels through an Nrf2/PMF -1 - mediated increase in spermidine/spermine _ acetyl transferase .
20055091	0	PX-18	64,69	phospholipase_A2	36,52	PX-18	phospholipase A2	null	151056	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Dermal and ocular safety of the new phospholipase_A2 inhibitors PX-18 and PX-13 formulated as drug nanosuspension .
15559765	0	PX-316	84,90	Akt	70,73	PX-316	Akt	MESH:C435044	11651(Tax:10090)	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|pharmacology pharmacology|nmod|END_ENTITY	In vivo molecular pharmacology and antitumor activity of the targeted Akt inhibitor PX-316 .
15967100	0	PX-478	148,154	HIF-1alpha	131,141	PX-478	HIF-1alpha	MESH:C492908	3091	Chemical	Gene	using|dobj|START_ENTITY END_ENTITY|acl|using	Dynamic contrast-enhanced and diffusion MRI show rapid and dramatic changes in tumor microenvironment in response to inhibition of HIF-1alpha using PX-478 .
16206237	0	PX-478	82,88	HIF-1alpha	55,65	PX-478	HIF-1alpha	MESH:C492908	3091	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Metabolite changes in HT-29 xenograft tumors following HIF-1alpha inhibition with PX-478 as studied by MR spectroscopy in vivo and ex vivo .
18202012	0	PX-478	41,47	hypoxia-inducible_factor-1alpha	79,110	PX-478	hypoxia-inducible factor-1alpha	MESH:C492908	3091	Chemical	Gene	activity|nmod|START_ENTITY mechanisms|nmod|activity mechanisms|appos|inhibitor inhibitor|nmod|END_ENTITY	Molecular mechanisms for the activity of PX-478 , an antitumor inhibitor of the hypoxia-inducible_factor-1alpha .
18729192	0	PX-478	0,6	hypoxia-inducible_factor-1alpha	24,55	PX-478	hypoxia-inducible factor-1alpha	MESH:C492908	3091	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	PX-478 , an inhibitor of hypoxia-inducible_factor-1alpha , enhances radiosensitivity of prostate_carcinoma cells .
20156803	0	PX-866	57,63	PI3K	41,45	PX-866	PI3K	MESH:C496788	5293	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Cellular and in vivo activity of a novel PI3K inhibitor , PX-866 , against human glioblastoma .
22933182	0	PXN727	70,76	p53	31,34	PXN727	p53	null	7157	Chemical	Gene	cells|nmod|START_ENTITY cells|compound|END_ENTITY	Radiosensitization of wildtype p53 cancer cells by the MDM2-inhibitor PXN727 is associated with altered heat_shock_protein_70 -LRB- Hsp70 -RRB- levels .
23483322	0	PY873	72,77	amido_phosphoribosyltransferase	26,57	PY873	amido phosphoribosyltransferase	null	353	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	In silico analysis of the amido_phosphoribosyltransferase inhibition by PY873 , PY899 and a derivative of isophthalic_acid .
26683793	0	PYPEP	66,71	peroxisome_proliferator-activated_receptor	12,54	PYPEP	peroxisome proliferator-activated receptor	null	5465	Chemical	Gene	START_ENTITY|nsubj|agonist agonist|amod|END_ENTITY	A selective peroxisome_proliferator-activated_receptor agonist PYPEP suppresses atherosclerosis in association with improvement of the serum lipoprotein profiles in human apolipoprotein_B100 and cholesteryl_ester_transfer_protein double transgenic_mice .
7505636	0	P_methyl_ester	41,55	neurokinin_A	68,80	P methyl ester	neurokinin A	null	6863	Chemical	Gene	study|nmod|START_ENTITY study|dep|END_ENTITY	Solution conformation study of substance P_methyl_ester and -LSB- Nle10 -RSB- - neurokinin_A -LRB- 4-10 -RRB- by NMR spectroscopy .
19671798	0	Paclitaxel	0,10	Bcl-2	29,34	Paclitaxel	Bcl-2	MESH:D017239	596	Chemical	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Paclitaxel directly binds to Bcl-2 and functionally mimics activity of Nur77 .
23415863	0	Paclitaxel	0,10	Bcl-2	22,27	Paclitaxel	Bcl-2	MESH:D017239	596	Chemical	Gene	attenuates|amod|START_ENTITY END_ENTITY|nsubj|attenuates	Paclitaxel attenuates Bcl-2 resistance to apoptosis in breast_cancer cells through an endoplasmic reticulum-mediated calcium release in a dosage dependent manner .
9288793	0	Paclitaxel	0,10	CA-125	50,56	Paclitaxel	CA-125	MESH:D017239	94025	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Paclitaxel - and docetaxel-dependent activation of CA-125 expression in human ovarian_carcinoma cells .
26146988	0	Paclitaxel	15,25	CDK5	0,4	Paclitaxel	CDK5	MESH:D017239	1020	Chemical	Gene	Sensitivity|compound|START_ENTITY Sensitivity|compound|END_ENTITY	CDK5 Regulates Paclitaxel Sensitivity in Ovarian_Cancer Cells by Modulating AKT Activation , p21Cip1 - and p27Kip1-Mediated G1 Cell Cycle Arrest and Apoptosis .
16969513	0	Paclitaxel	0,10	EGFR	87,91	Paclitaxel	EGFR	MESH:D017239	1956	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|death death|nmod|activation activation|nmod|END_ENTITY	Paclitaxel and ceramide synergistically induce cell death with transient activation of EGFR and ERK pathway in pancreatic_cancer cells .
25961928	0	Paclitaxel	0,10	FOXM1	19,24	Paclitaxel	FOXM1	MESH:D017239	2305	Chemical	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	Paclitaxel targets FOXM1 to regulate KIF20A in mitotic catastrophe and breast_cancer paclitaxel resistance .
25961928	0	Paclitaxel	0,10	FOXM1	19,24	Paclitaxel	FOXM1	MESH:D017239	2305	Chemical	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	Paclitaxel targets FOXM1 to regulate KIF20A in mitotic catastrophe and breast_cancer paclitaxel resistance .
26985944	0	Paclitaxel	0,10	JNK	57,60	Paclitaxel	JNK	MESH:D017239	5599	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|pathway pathway|compound|END_ENTITY	Paclitaxel induces apoptosis in leukemia cells through a JNK activation-dependent pathway .
18650420	0	Paclitaxel	0,10	MD-2	39,43	Paclitaxel	MD-2	MESH:D017239	17087(Tax:10090)	Chemical	Gene	START_ENTITY|xcomp|binding binding|nmod|END_ENTITY	Paclitaxel binding to human and murine MD-2 .
17564303	0	Paclitaxel	0,10	N-acetyltransferase	20,39	Paclitaxel	N-acetyltransferase	MESH:D017239	6046	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Paclitaxel inhibits N-acetyltransferase activity and gene expression in human stomach_tumor cells -LRB- SC-M1 -RRB- .
23838193	0	Paclitaxel	0,10	P-gp	39,43	Paclitaxel	P-gp	MESH:D017239	67078(Tax:10090)	Chemical	Gene	nanosuspensions|amod|START_ENTITY nanosuspensions|acl|coated coated|nmod|surfactants surfactants|compound|END_ENTITY	Paclitaxel nanosuspensions coated with P-gp inhibitory surfactants : I. Acute toxicity and pharmacokinetics studies .
24632038	0	Paclitaxel	0,10	P-gp	38,42	Paclitaxel	P-gp	MESH:D017239	5243	Chemical	Gene	nanosuspension|amod|START_ENTITY coated|nsubj|nanosuspension coated|nmod|surfactants surfactants|compound|END_ENTITY	Paclitaxel nanosuspension coated with P-gp inhibitory surfactants : II .
26182353	0	Paclitaxel	42,52	P-gp	100,104	Paclitaxel	P-gp	MESH:D017239	5243	Chemical	Gene	Formulation|nmod|START_ENTITY Induce|nsubj|Formulation Induce|nmod|Up-Regulation Up-Regulation|nmod|END_ENTITY	Abraxane , the Nanoparticle Formulation of Paclitaxel Can Induce Drug Resistance by Up-Regulation of P-gp .
18030015	0	Paclitaxel	38,48	S-1	13,16	Paclitaxel	S-1	MESH:D017239	5707	Chemical	Gene	combined|nmod|START_ENTITY combined|nsubj|Efficacy Efficacy|nmod|END_ENTITY	-LSB- Efficacy of S-1 combined with weekly Paclitaxel for gastric_cancer with cancerous ascites -RSB- .
26982692	0	Paclitaxel	62,72	S-1	78,81	Paclitaxel	S-1	MESH:D017239	5707	Chemical	Gene	Study|nmod|START_ENTITY Study|dep|END_ENTITY	Multicenter Phase II Study of Intravenous and Intraperitoneal Paclitaxel With S-1 for Pancreatic_Ductal_Adenocarcinoma Patients With Peritoneal Metastasis .
25931810	0	Paclitaxel	0,10	STAT3	103,108	Paclitaxel	STAT3	MESH:D017239	25125(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|advcl|inhibiting inhibiting|dobj|signaling signaling|compound|END_ENTITY	Paclitaxel attenuates renal interstitial fibroblast activation and interstitial fibrosis by inhibiting STAT3 signaling .
26930229	0	Paclitaxel	0,10	TGF-b	76,81	Paclitaxel	TGF-b	MESH:D017239	7040	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|proliferation proliferation|nmod|END_ENTITY	Paclitaxel inhibits cell proliferation and collagen lattice contraction via TGF-b signaling pathway in human tenon 's fibroblasts in vitro .
16250671	0	Paclitaxel	0,10	TGFbeta	21,28	Paclitaxel	TGFbeta	MESH:D017239	21803(Tax:10090)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Paclitaxel modulates TGFbeta signaling in scleroderma skin grafts in immunodeficient mice .
20346445	0	Paclitaxel	0,10	TLR4	73,77	Paclitaxel	TLR4	MESH:D017239	21898(Tax:10090)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Paclitaxel enhances early dendritic cell maturation and function through TLR4 signaling in mice .
23037716	0	Paclitaxel	0,10	aurora_kinase_A	24,39	Paclitaxel	aurora kinase A	MESH:D017239	6790	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Paclitaxel and CYC3 , an aurora_kinase_A inhibitor , synergise in pancreatic_cancer cells but not bone marrow precursor cells .
11034069	0	Paclitaxel	0,10	cytochrome_c	30,42	Paclitaxel	cytochrome c	MESH:D017239	54205	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|release release|nmod|END_ENTITY	Paclitaxel induces release of cytochrome_c from mitochondria isolated from human neuroblastoma cells ' .
12761496	0	Paclitaxel	0,10	p21	21,24	Paclitaxel	p21	MESH:D017239	644914	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|synthesis synthesis|amod|END_ENTITY	Paclitaxel increases p21 synthesis and accumulation of its AKT-phosphorylated form in the cytoplasm of cancer cells .
10421546	0	Paclitaxel	0,10	p53	39,42	Paclitaxel	p53	MESH:D017239	7157	Chemical	Gene	sensitivity|amod|START_ENTITY correlates|nsubj|sensitivity correlates|nmod|status status|compound|END_ENTITY	Paclitaxel sensitivity correlates with p53 status and DNA fragmentation , but not G2/M accumulation .
10871860	0	Paclitaxel	0,10	p53	45,48	Paclitaxel	p53	MESH:D017239	7157	Chemical	Gene	selects|nsubj|START_ENTITY selects|nmod|END_ENTITY	Paclitaxel selects for mutant or pseudo-null p53 in drug resistance associated with tubulin mutations in human cancer .
12684432	0	Paclitaxel	59,69	p53	94,97	Paclitaxel	p53	MESH:D017239	7157	Chemical	Gene	effects|nmod|START_ENTITY potentiates|dobj|effects potentiates|nmod|lines lines|compound|END_ENTITY	Low-dose fractionated radiation potentiates the effects of Paclitaxel in wild-type and mutant p53 head_and_neck_tumor cell lines .
17823933	0	Paclitaxel	0,10	p53	108,111	Paclitaxel	p53	MESH:D017239	7157	Chemical	Gene	enhanced|nsubj|START_ENTITY enhanced|nmod|suppression suppression|nmod|growth growth|nmod|pathway pathway|compound|END_ENTITY	Paclitaxel enhanced radiation sensitization for the suppression of human prostate_cancer tumor growth via a p53 independent pathway .
18322419	0	Paclitaxel	0,10	vascular_endothelial_growth_factor	19,53	Paclitaxel	vascular endothelial growth factor	MESH:D017239	7422	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Paclitaxel induces vascular_endothelial_growth_factor expression through reactive oxygen species production .
26089940	0	Paeoniflorin	14,26	CYP3A4	51,57	Paeoniflorin	CYP3A4	MESH:C015423	1576	Chemical	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|END_ENTITY	Comparison of Paeoniflorin and Albiflorin on Human CYP3A4 and CYP2D6 .
22411721	0	Paeoniflorin	0,12	G-protein-coupled_receptor_kinase_2	88,123	Paeoniflorin	G-protein-coupled receptor kinase 2	MESH:C015423	25238(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Paeoniflorin inhibits proliferation of fibroblast-like synoviocytes through suppressing G-protein-coupled_receptor_kinase_2 .
21542832	0	Paeoniflorin	0,12	ICAM-1	77,83	Paeoniflorin	ICAM-1	MESH:C015423	3383	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|nmod|END_ENTITY	Paeoniflorin suppresses the expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- in endotoxin-treated human monocytic cells .
26898442	0	Paeoniflorin	0,12	Notch-1	92,99	Paeoniflorin	Notch-1	MESH:C015423	4851	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Paeoniflorin inhibits proliferation and invasion of breast_cancer cells through suppressing Notch-1 signaling pathway .
25161157	0	Paeonol	0,7	GM-CSF	36,42	Paeonol	GM-CSF	MESH:C013638	1437	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|dobj|expression expression|amod|END_ENTITY	Paeonol inhibited TNF-alpha-induced GM-CSF expression in fibroblast-like synoviocytes .
17276892	0	Paeonol	0,7	intercellular_adhesion_molecule-1	19,52	Paeonol	intercellular adhesion molecule-1	MESH:C013638	3383	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Paeonol suppresses intercellular_adhesion_molecule-1 expression in tumor_necrosis_factor-alpha-stimulated human umbilical vein endothelial cells by blocking p38 , ERK and nuclear factor-kappaB signaling pathways .
25522409	0	Paliperidone	0,12	Toll-like_receptor_4	28,48	Paliperidone	Toll-like receptor 4	MESH:C079150	29260(Tax:10116)	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|dobj|END_ENTITY	Paliperidone prevents brain Toll-like_receptor_4 pathway activation and neuroinflammation in rat models of acute and chronic restraint stress .
17118340	0	Palmitate	0,9	AMP-activated_protein_kinase	20,48	Palmitate	AMP-activated protein kinase	CHEBI:7896	78975(Tax:10116)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Palmitate activates AMP-activated_protein_kinase and regulates insulin secretion from beta cells .
20727556	0	Palmitate	0,9	C-reactive_protein	18,36	Palmitate	C-reactive protein	CHEBI:7896	1401	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Palmitate induces C-reactive_protein expression in human aortic endothelial cells .
20526368	0	Palmitate	0,9	IL-6	18,22	Palmitate	IL-6	CHEBI:7896	3569	Chemical	Gene	START_ENTITY|acl|induced induced|dobj|expression expression|amod|END_ENTITY	Palmitate induced IL-6 and MCP-1 expression in human bladder smooth muscle cells provides a link between diabetes_and_urinary_tract_infections .
21054880	0	Palmitate	0,9	IL-6	45,49	Palmitate	IL-6	CHEBI:7896	3569	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|compound|END_ENTITY	Palmitate and insulin synergistically induce IL-6 expression in human monocytes .
24396871	0	Palmitate	0,9	Nur77	20,25	Palmitate	Nur77	CHEBI:7896	3164	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Palmitate increases Nur77 expression by modulating ZBP89 and Sp1 binding to the Nur77 proximal promoter in pancreatic b-cells .
24396871	0	Palmitate	0,9	Nur77	80,85	Palmitate	Nur77	CHEBI:7896	3164	Chemical	Gene	increases|nsubj|START_ENTITY increases|advcl|modulating modulating|xcomp|binding binding|nmod|promoter promoter|amod|END_ENTITY	Palmitate increases Nur77 expression by modulating ZBP89 and Sp1 binding to the Nur77 proximal promoter in pancreatic b-cells .
24512852	0	Palmitate	0,9	Nur77	20,25	Palmitate	Nur77	CHEBI:7896	3164	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Palmitate increases Nur77 expression by modulating ZBP89 and Sp1 binding to the Nur77 proximal promoter in pancreatic b-cells .
24512852	0	Palmitate	0,9	Nur77	80,85	Palmitate	Nur77	CHEBI:7896	3164	Chemical	Gene	increases|nsubj|START_ENTITY increases|advcl|modulating modulating|xcomp|binding binding|nmod|promoter promoter|amod|END_ENTITY	Palmitate increases Nur77 expression by modulating ZBP89 and Sp1 binding to the Nur77 proximal promoter in pancreatic b-cells .
26449458	0	Palmitate	0,9	PERK	66,70	Palmitate	PERK	CHEBI:7896	9451	Chemical	Gene	increases|nsubj|START_ENTITY increases|nmod|activation activation|nmod|END_ENTITY	Palmitate increases musclin gene expression through activation of PERK signaling pathway in C2C12 myotubes .
24924631	0	Palmitate	0,9	SHIP2	18,23	Palmitate	SHIP2	CHEBI:7896	16332(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nummod|END_ENTITY	Palmitate induces SHIP2 expression via the ceramide-mediated activation of NF-kB , and JNK in skeletal muscle cells .
23968646	0	Palmitate	0,9	STAT3	72,77	Palmitate	STAT3	CHEBI:7896	6774	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Palmitate induces transcriptional regulation of BACE1 and presenilin by STAT3 in neurons mediated by astrocytes .
24685558	0	Palmitate	0,9	TRB3	18,22	Palmitate	TRB3	CHEBI:7896	57761	Chemical	Gene	START_ENTITY|dobj|Expression Expression|compound|END_ENTITY	Palmitate Induces TRB3 Expression and Promotes Apoptosis in Human Liver Cells .
23826669	0	Palmitate	0,9	Toll-like_receptor_4	92,112	Palmitate	Toll-like receptor 4	CHEBI:7896	7099	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|cells cells|nmod|pathway pathway|amod|/ /|amod|END_ENTITY	Palmitate induces interleukin-8 expression in human aortic vascular smooth muscle cells via Toll-like_receptor_4 / nuclear factor-kB pathway -LRB- TLR4/NF-kB -8 -RRB- .
18840759	0	Palmitate	0,9	insulin	74,81	Palmitate	insulin	CHEBI:7896	3630	Chemical	Gene	macrophages|amod|START_ENTITY evoke|nsubj|macrophages evoke|xcomp|contrasting contrasting|dobj|responses responses|compound|END_ENTITY	Palmitate - and lipopolysaccharide-activated macrophages evoke contrasting insulin responses in muscle cells .
20006364	0	Palmitate	0,9	insulin	18,25	Palmitate	insulin	CHEBI:7896	3630	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|resistance resistance|compound|END_ENTITY	Palmitate induces insulin resistance without significant intracellular triglyceride accumulation in HepG2 cells .
25527164	0	Palmitate	0,9	insulin	127,134	Palmitate	insulin	CHEBI:7896	3630	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|enhancing enhancing|dobj|degradation degradation|nmod|END_ENTITY	Palmitate induces insulin resistance in human HepG2 hepatocytes by enhancing ubiquitination and proteasomal degradation of key insulin signaling molecules .
25527164	0	Palmitate	0,9	insulin	18,25	Palmitate	insulin	CHEBI:7896	3630	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|resistance resistance|compound|END_ENTITY	Palmitate induces insulin resistance in human HepG2 hepatocytes by enhancing ubiquitination and proteasomal degradation of key insulin signaling molecules .
9519739	0	Palmitate	0,9	insulin	78,85	Palmitate	insulin	CHEBI:7896	3630	Chemical	Gene	mimic|nsubj|START_ENTITY mimic|advcl|augmenting augmenting|dobj|release release|compound|END_ENTITY	Palmitate and myristate selectively mimic the effect of glucose in augmenting insulin release in the absence of extracellular Ca2 + .
15028733	0	Palmitate	0,9	interleukin-6	70,83	Palmitate	interleukin-6	CHEBI:7896	3569	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Palmitate , but not unsaturated fatty_acids , induces the expression of interleukin-6 in human myotubes through proteasome-dependent activation of nuclear factor-kappaB .
23826669	0	Palmitate	0,9	interleukin-8	18,31	Palmitate	interleukin-8	CHEBI:7896	3576	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Palmitate induces interleukin-8 expression in human aortic vascular smooth muscle cells via Toll-like_receptor_4 / nuclear factor-kB pathway -LRB- TLR4/NF-kB -8 -RRB- .
26449458	0	Palmitate	0,9	musclin	20,27	Palmitate	musclin	CHEBI:7896	344901	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Palmitate increases musclin gene expression through activation of PERK signaling pathway in C2C12 myotubes .
24369243	0	Palmitate	1,10	toll-like_receptor_4	20,40	Palmitate	toll-like receptor 4	CHEBI:7896	399541(Tax:9823)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	-LSB- Palmitate enhances toll-like_receptor_4 expression and signaling in porcine vascular endothelial cells -RSB- .
23840832	0	Palmitic_acid	0,13	ACSL3	91,96	Palmitic acid	ACSL3	MESH:D019308	2181	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Palmitic_acid induces osteoblastic differentiation in vascular smooth muscle cells through ACSL3 and NF-kB , novel targets of eicosapentaenoic_acid .
17467667	0	Palmitic_acid	0,13	IP-10	22,27	Palmitic acid	IP-10	MESH:D019308	3627	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Palmitic_acid induces IP-10 expression in human macrophages via NF-kappaB activation .
24508264	0	Palmitic_acid	0,13	apolipoprotein_M	25,41	Palmitic acid	apolipoprotein M	MESH:D019308	55937	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Palmitic_acid suppresses apolipoprotein_M gene expression via the pathway of PPARb / in HepG2 cells .
26475209	0	Palmitic_acid	0,13	insulin	47,54	Palmitic acid	insulin	MESH:D019308	3630	Chemical	Gene	START_ENTITY|nsubj|resistance resistance|compound|END_ENTITY	Palmitic_acid but not palmitoleic_acid induces insulin resistance in a human endothelial cell line by decreasing SERCA pump expression .
17680645	0	Palmitic_acid	0,13	interleukin-8	61,74	Palmitic acid	interleukin-8	MESH:D019308	3576	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|nmod|END_ENTITY	Palmitic_acid induces production of proinflammatory cytokine interleukin-8 from hepatocytes .
19782984	0	Palmitic_acid	0,13	lectin-like_oxidized_LDL_receptor	23,56	Palmitic acid	lectin-like oxidized LDL receptor	MESH:D019308	108078(Tax:10090)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Palmitic_acid enhances lectin-like_oxidized_LDL_receptor -LRB- LOX-1 -RRB- expression and promotes uptake of oxidized LDL in macrophage cells .
25724108	0	Palmitic_acid	0,13	leptin	30,36	Palmitic acid	leptin	MESH:D019308	16846(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|resistance resistance|compound|END_ENTITY	Palmitic_acid induces central leptin resistance and impairs hepatic_glucose_and_lipid_metabolism in male mice .
24637783	0	Palmitoyl	0,9	Zdhhc13	27,34	Palmitoyl	Zdhhc13	CHEBI:45021	243983(Tax:10090)	Chemical	Gene	acyltransferase|amod|START_ENTITY acyltransferase|appos|END_ENTITY	Palmitoyl acyltransferase , Zdhhc13 , facilitates bone mass acquisition by regulating postnatal epiphyseal development and endochondral ossification : a mouse model .
26288350	0	Palmitoyl	100,109	Zdhhc13	122,129	Palmitoyl	Zdhhc13	CHEBI:45021	243983(Tax:10090)	Chemical	Gene	Gene|compound|START_ENTITY Gene|compound|END_ENTITY	Increased Susceptibility to Skin_Carcinogenesis Associated with a Spontaneous Mouse Mutation in the Palmitoyl Transferase Zdhhc13 Gene .
24440533	0	Palmitoylethanolamide	0,21	rMCP-5	31,37	Palmitoylethanolamide	rMCP-5	MESH:C005958	25627(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Palmitoylethanolamide inhibits rMCP-5 expression by regulating MITF activation in rat chronic granulomatous_inflammation .
2562838	0	Palytoxin	0,9	epidermal_growth_factor_receptor	29,61	Palytoxin	epidermal growth factor receptor	MESH:C010272	13649(Tax:10090)	Chemical	Gene	down-modulates|nsubj|START_ENTITY down-modulates|dobj|END_ENTITY	Palytoxin down-modulates the epidermal_growth_factor_receptor through a sodium-dependent pathway .
18776065	0	Pamapimod	0,9	p38	19,22	Pamapimod	p38	MESH:C533858	1432	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Pamapimod , a novel p38 mitogen-activated protein kinase inhibitor : preclinical analysis of efficacy and selectivity .
20519142	0	Pamidronate	0,11	bcl-2	35,40	Pamidronate	bcl-2	MESH:C019248	596	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Pamidronate inhibits antiapoptotic bcl-2 expression through inhibition of the mevalonate pathway in prostate_cancer PC-3 cells .
12819186	0	Panaxadiol	0,10	Cdk2	52,56	Panaxadiol	Cdk2	MESH:C004564	1017	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Panaxadiol selectively inhibits cyclin_A-associated Cdk2 activity by elevating p21WAF1/CIP1 protein levels in mammalian cells .
19857566	0	Panaxatriol_saponins	0,20	thioredoxin-1	62,75	Panaxatriol saponins	thioredoxin-1	null	116484(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Panaxatriol_saponins extracted from Panax notoginseng induces thioredoxin-1 and prevents 1-methyl-4-phenylpyridinium ion-induced neurotoxicity .
26421996	0	Panaxydol	0,9	EGFR	83,87	Panaxydol	EGFR	MESH:C055778	13649(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|amod|END_ENTITY	Panaxydol , a component of Panax_ginseng , induces apoptosis in cancer cells through EGFR activation and ER stress and inhibits tumor growth in mouse models .
1451737	0	Pancopride	0,10	5-HT3_receptor	37,51	Pancopride	5-HT3 receptor	MESH:C078370	79246(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Pancopride , a potent and long-acting 5-HT3_receptor antagonist , is orally effective against anticancer drug-evoked emesis .
22992957	0	Pancortins	0,10	amyloid_precursor_protein	25,50	Pancortins	amyloid precursor protein	null	351	Chemical	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	Pancortins interact with amyloid_precursor_protein and modulate cortical cell migration .
15726366	0	Pancratistatin	0,14	caspase-3	42,51	Pancratistatin	caspase-3	MESH:C044997	836	Chemical	Gene	causes|nsubj|START_ENTITY causes|dobj|activation activation|nmod|END_ENTITY	Pancratistatin causes early activation of caspase-3 and the flipping of phosphatidyl_serine followed by rapid apoptosis specifically in human lymphoma cells .
1397969	0	Pancreastatin	0,13	insulin	76,83	Pancreastatin	insulin	MESH:C050836	3630	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|END_ENTITY	Pancreastatin and its 33-49 C-terminal fragment inhibit glucagon-stimulated insulin in vivo .
3537810	0	Pancreastatin	0,13	insulin	56,63	Pancreastatin	insulin	MESH:C050836	3630	Chemical	Gene	START_ENTITY|appos|peptide peptide|acl:relcl|inhibits inhibits|dobj|secretion secretion|compound|END_ENTITY	Pancreastatin , a novel pancreatic peptide that inhibits insulin secretion .
8689670	0	Pancreastatin	0,13	insulin	23,30	Pancreastatin	insulin	MESH:C050836	3630	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|compound|END_ENTITY	Pancreastatin inhibits insulin secretion in RINm5F cells through obstruction of G-protein mediated , calcium-directed exocytosis .
14685697	0	Pancreastatin	0,13	leptin	58,64	Pancreastatin	leptin	MESH:C050836	25608(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Pancreastatin , a chromogranin_A-derived peptide , inhibits leptin and enhances UCP-2 expression in isolated rat adipocytes .
25438056	0	Paracetamol	23,34	TRPA1	79,84	Paracetamol	TRPA1	MESH:D000082	8989	Chemical	Gene	Analogues|nmod|START_ENTITY Analogues|nmod|END_ENTITY	Adamantyl Analogues of Paracetamol as Potent Analgesic Drugs via Inhibition of TRPA1 .
23371851	0	Paracrine	0,9	CCR9	43,47	Paracrine	CCR9	null	10803	Chemical	Gene	Activation|compound|START_ENTITY Activation|nmod|END_ENTITY	Paracrine Activation of Chemokine Receptor CCR9 Enhances The Invasiveness of Pancreatic_Cancer Cells .
19008002	0	Paracrine	0,9	CD34	21,25	Paracrine	CD34	null	947	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|END_ENTITY	Paracrine effects of CD34 progenitor cells on angiogenic endothelial sprouting .
12495621	0	Paracrine	0,9	Ca2	43,46	Paracrine	Ca2	null	12349(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|release release|amod|END_ENTITY	Paracrine intercellular communication by a Ca2 + - and SNARE-independent release of GABA and glutamate prior to synapse formation .
8161796	0	Paracrine	0,9	Fc_gamma_RIII	28,41	Paracrine	Fc gamma RIII	null	2214	Chemical	Gene	downregulation|amod|START_ENTITY downregulation|nmod|END_ENTITY	Paracrine downregulation of Fc_gamma_RIII in human monocyte-derived_macrophages induced by phagocytosis of nonopsonized particles .
22031867	0	Paracrine	0,9	GM-CSF	24,30	Paracrine	GM-CSF	null	1437	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Paracrine inhibition of GM-CSF signaling by human_cytomegalovirus in monocytes differentiating to dendritic cells .
21494550	0	Paracrine	0,9	IL-33	10,15	Paracrine	IL-33	null	77125(Tax:10090)	Chemical	Gene	stimulation|amod|START_ENTITY stimulation|compound|END_ENTITY	Paracrine IL-33 stimulation enhances lipopolysaccharide-mediated macrophage activation .
22218692	0	Paracrine	0,9	MYCN	28,32	Paracrine	MYCN	null	4613	Chemical	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Paracrine signaling through MYCN enhances tumor-vascular interactions in neuroblastoma .
24913779	0	Paracrine	0,9	P2X7_receptor	25,38	Paracrine	P2X7 receptor	null	5027	Chemical	Gene	stimulation|amod|START_ENTITY stimulation|nmod|END_ENTITY	Paracrine stimulation of P2X7_receptor by ATP activates a proliferative pathway in ovarian_carcinoma cells .
12667619	0	Paracrine	0,9	PAMP	21,25	Paracrine	PAMP	null	133	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|END_ENTITY	Paracrine effects of PAMP and adrenomedullin on the human adrenal H295R cell line : PAMP but not adrenomedullin stimulates DHEA secretion .
26492366	0	Paracrine	0,9	Rap1	60,64	Paracrine	Rap1	null	5906	Chemical	Gene	regulation|amod|START_ENTITY regulation|dep|role role|nmod|END_ENTITY	Paracrine regulation in mesenchymal stem cells : the role of Rap1 .
11777931	0	Paracrine	0,9	VEGF	82,86	Paracrine	VEGF	null	22339(Tax:10090)	Chemical	Gene	functions|compound|START_ENTITY functions|appos|END_ENTITY	Paracrine and autocrine functions of neuronal vascular_endothelial_growth_factor -LRB- VEGF -RRB- in the central nervous system .
10714896	0	Paracrine	0,9	angiotensin-converting-enzyme	21,50	Paracrine	angiotensin-converting-enzyme	null	1636	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|END_ENTITY	Paracrine effects of angiotensin-converting-enzyme - and angiotensin-II-receptor - inhibition on transcapillary glucose transport in humans .
9547510	0	Paracrine	0,9	bFGF	21,25	Paracrine	bFGF	null	14173(Tax:10090)	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|END_ENTITY	Paracrine effects of bFGF and KGF on the process of mouse blastocyst_implantation .
17250815	0	Paracrine	0,9	cyclooxygenase-2	36,52	Paracrine	cyclooxygenase-2	null	5743	Chemical	Gene	up-regulation|amod|START_ENTITY up-regulation|nmod|END_ENTITY	Paracrine up-regulation of monocyte cyclooxygenase-2 by platelets : role of transforming_growth_factor-beta1 .
10082423	0	Paracrine	0,9	decorin	41,48	Paracrine	decorin	null	1634	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|expression expression|compound|END_ENTITY	Paracrine or virus-mediated induction of decorin expression by endothelial cells contributes to tube formation and prevention of apoptosis in collagen lattices .
8473832	0	Paracrine	0,9	epidermal_growth_factor_receptor	26,58	Paracrine	epidermal growth factor receptor	null	24329(Tax:10116)	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|END_ENTITY	Paracrine effects via the epidermal_growth_factor_receptor in the rodent testis may be mediated by non-Leydig interstitial cells .
16452162	0	Paracrine	0,9	estrogen_receptor_alpha	43,66	Paracrine	estrogen receptor alpha	null	13982(Tax:10090)	Chemical	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Paracrine signaling through the epithelial estrogen_receptor_alpha is required for proliferation and morphogenesis in the mammary gland .
11420677	0	Paracrine	0,9	fibroblast_growth_factor-4	35,61	Paracrine	fibroblast growth factor-4	null	428857(Tax:9031)	Chemical	Gene	effects|compound|START_ENTITY effects|nmod|END_ENTITY	Paracrine and autocrine effects of fibroblast_growth_factor-4 in endothelial cells .
16889513	0	Paracrine	0,9	insulin-like_growth_factor_1	21,49	Paracrine	insulin-like growth factor 1	null	16000(Tax:10090)	Chemical	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	Paracrine release of insulin-like_growth_factor_1 from a bioengineered tissue stimulates skeletal muscle growth in vitro .
10404828	0	Paracrine	0,9	insulin-like_growth_factor_I	24,52	Paracrine	insulin-like growth factor I	null	3479	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Paracrine regulation of insulin-like_growth_factor_I -LRB- IGF-I -RRB- an IGF-II on prostaglandins_F2alpha and E2 synthesis by human corpus luteum in vitro : a possible balance of luteotropic and luteolytic effects .
9603419	0	Paracrine	0,9	vascular_endothelial_growth_factor	38,72	Paracrine	vascular endothelial growth factor	null	7422	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Paracrine and autocrine regulation of vascular_endothelial_growth_factor during tissue differentiation in the quail .
8212564	0	Paracrystalline	0,15	aphid_transmission_factor	54,79	Paracrystalline	aphid transmission factor	null	2668	Chemical	Gene	structure|amod|START_ENTITY structure|nmod|END_ENTITY	Paracrystalline structure of cauliflower_mosaic_virus aphid_transmission_factor produced both in plants and in a heterologous system and relationship with a solubilized active form .
15580289	0	Parafibromin	0,12	PRAD1	100,105	Parafibromin	PRAD1	null	595	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Parafibromin , product of the hyperparathyroidism-jaw_tumor_syndrome_gene_HRPT2 , regulates cyclin_D1 / PRAD1 expression .
15580289	0	Parafibromin	0,12	cyclin_D1	90,99	Parafibromin	cyclin D1	null	595	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nummod|END_ENTITY	Parafibromin , product of the hyperparathyroidism-jaw_tumor_syndrome_gene_HRPT2 , regulates cyclin_D1 / PRAD1 expression .
12831782	0	Paraoxon	0,8	EL4	30,33	Paraoxon	EL4	MESH:D010261	111979(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|apoptosis apoptosis|nmod|cells cells|nummod|END_ENTITY	Paraoxon induces apoptosis in EL4 cells via activation of mitochondrial pathways .
4049405	0	Paraoxon	0,8	neurotoxic_esterase	29,48	Paraoxon	neurotoxic esterase	MESH:D010261	10908	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Paraoxon reversibly inhibits neurotoxic_esterase .
20851755	0	Paraquat	0,8	COX-2	35,40	Paraquat	COX-2	MESH:D010269	5743	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Paraquat induces cyclooxygenase-2 -LRB- COX-2 -RRB- implicated toxicity in human neuroblastoma SH-SY5Y cells .
24523768	0	Paraquat	0,8	Cyclooxygenase-2	31,47	Paraquat	Cyclooxygenase-2	MESH:D010269	29527(Tax:10116)	Chemical	Gene	Up-regulates|compound|START_ENTITY END_ENTITY|nsubj|Up-regulates	Paraquat Exposure Up-regulates Cyclooxygenase-2 in the Lungs , Liver and Kidneys in Rats .
20035857	0	Paraquat	0,8	connective_tissue_growth_factor	19,50	Paraquat	connective tissue growth factor	MESH:D010269	1490	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Paraquat increases connective_tissue_growth_factor and collagen expression via angiotensin signaling pathway in human lung fibroblasts .
24556028	0	Paraquat	0,8	connective_tissue_growth_factor	19,50	Paraquat	connective tissue growth factor	MESH:D010269	1490	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Paraquat increases connective_tissue_growth_factor expression and impairs lung fibroblast proliferation and viscoelasticity .
23325452	0	Parecoxib	0,9	CHOP	21,25	Parecoxib	CHOP	MESH:C409945	29467(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	Parecoxib suppresses CHOP and Foxo1 nuclear translocation , but increases GRP78 levels in a rat model of focal ischemia .
18336751	0	Parecoxib	0,9	COX-2	31,36	Parecoxib	COX-2	MESH:C409945	4513	Chemical	Gene	START_ENTITY|nmod|alternative alternative|nmod|hypersensitivity hypersensitivity|compound|END_ENTITY	Parecoxib as an alternative in COX-2 hypersensitivity .
26426591	0	Parecoxib	0,9	Cyclooxygenase-2	57,73	Parecoxib	Cyclooxygenase-2	MESH:C409945	29527(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|Inhibition Inhibition|nmod|RNA RNA|compound|END_ENTITY	Parecoxib Increases Blood Pressure Through Inhibition of Cyclooxygenase-2 Messenger RNA in an Experimental Model .
12657858	0	Parecoxib_sodium	0,16	cyclooxygenase_2	31,47	Parecoxib sodium	cyclooxygenase 2	MESH:C409945	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Parecoxib_sodium , a parenteral cyclooxygenase_2 selective inhibitor , improves morphine analgesia and is opioid-sparing following total_hip_arthroplasty .
19259778	0	Paricalcitol	0,12	TNF-alpha	64,73	Paricalcitol	TNF-alpha	MESH:C084656	7124	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	Paricalcitol reduces basal and lipopolysaccharide-induced -LRB- LPS -RRB- TNF-alpha and IL-8 production by human peripheral blood mononuclear cells .
11910269	0	Paroxetine	0,10	CYP2D6	69,75	Paroxetine	CYP2D6	MESH:D017374	1565	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|concentrations concentrations|nmod|R R|dep|methadone methadone|nmod|metabolizers metabolizers|nummod|END_ENTITY	Paroxetine increases steady-state concentrations of -LRB- R -RRB- - methadone in CYP2D6 extensive but not poor metabolizers .
25261563	0	Paroxetine	0,10	CYP2D6	75,81	Paroxetine	CYP2D6	MESH:D017374	1565	Chemical	Gene	Markedly|compound|START_ENTITY Increases|nsubj|Markedly Increases|parataxis|Increase Increase|nsubj|May May|compound|END_ENTITY	Paroxetine Markedly Increases Plasma Concentrations of Ophthalmic_Timolol ; CYP2D6 Inhibitors May Increase the Risk of Cardiovascular Adverse Effects of 0.5 % Timolol Eye Drops .
25943764	0	Paroxetine	112,122	CYP2D6	102,108	Paroxetine	CYP2D6	MESH:D017374	1565	Chemical	Gene	Altering|nmod|START_ENTITY Altering|dep|Reducing Reducing|dobj|Inhibition Inhibition|nmod|END_ENTITY	Altering Metabolic Profiles of Drugs by Precision Deuteration : Reducing Mechanism-Based Inhibition of CYP2D6 by Paroxetine .
25943764	0	Paroxetine	112,122	CYP2D6	102,108	Paroxetine	CYP2D6	MESH:D017374	1565	Chemical	Gene	Altering|nmod|START_ENTITY Altering|dep|Reducing Reducing|dobj|Inhibition Inhibition|nmod|END_ENTITY	Altering Metabolic Profiles of Drugs by Precision Deuteration : Reducing Mechanism-Based Inhibition of CYP2D6 by Paroxetine .
26350273	0	Paroxetine	11,21	CYP2D6	25,31	Paroxetine	CYP2D6	MESH:D017374	1565	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|compound|END_ENTITY	Effects of Paroxetine , a CYP2D6 Inhibitor , on the Pharmacokinetic Properties of Hydrocodone After Coadministration With a Single-entity , Once-daily , Extended-release Hydrocodone Tablet .
25744603	0	Paroxetine	0,10	TNFa	48,52	Paroxetine	TNFa	MESH:D017374	21926(Tax:10090)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Paroxetine differentially modulates LPS-induced TNFa and IL-6 production in mouse macrophages .
19934779	0	Paroxetine	0,10	brain-derived_neurotrophic_factor	21,54	Paroxetine	brain-derived neurotrophic factor	MESH:D017374	627	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Paroxetine increases brain-derived_neurotrophic_factor in postmenopausal women .
21178384	0	Paroxetine	0,10	brain-derived_neurotrophic_factor	47,80	Paroxetine	brain-derived neurotrophic factor	MESH:D017374	627	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|mRNA mRNA|amod|END_ENTITY	Paroxetine rapidly modulates the expression of brain-derived_neurotrophic_factor mRNA and protein in a human glioblastoma-astrocytoma cell line .
15903129	0	Paroxetine	0,10	cytochrome_P450_2D6	14,33	Paroxetine	cytochrome P450 2D6	MESH:D017374	1565	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Paroxetine , a cytochrome_P450_2D6 inhibitor , diminishes the stereoselective O-demethylation and reduces the hypoalgesic effect of tramadol .
22882301	0	Paroxetine	0,10	g_protein-coupled_receptor_kinase_2	36,71	Paroxetine	g protein-coupled receptor kinase 2	MESH:D017374	110355(Tax:10090)	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Paroxetine is a direct inhibitor of g_protein-coupled_receptor_kinase_2 and increases_myocardial_contractility .
8993087	0	Paroxetine	0,10	nitric_oxide_synthase	22,43	Paroxetine	nitric oxide synthase	MESH:D017374	4843	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|compound|END_ENTITY	Paroxetine is a novel nitric_oxide_synthase inhibitor .
10812044	0	Paroxetine	0,10	norepinephrine_transporter	30,56	Paroxetine	norepinephrine transporter	MESH:D017374	83511(Tax:10116)	Chemical	Gene	START_ENTITY|xcomp|binding binding|nmod|END_ENTITY	Paroxetine binding to the rat norepinephrine_transporter in vivo .
9214741	0	Parthenolide	12,24	5HT2A	28,33	Parthenolide	5HT2A	MESH:C002669	29595(Tax:10116)	Chemical	Gene	Activity|nmod|START_ENTITY Activity|nmod|receptors receptors|nummod|END_ENTITY	Activity of Parthenolide at 5HT2A receptors .
21992677	0	Parthenolide	0,12	ERK	22,25	Parthenolide	ERK	MESH:C002669	5594	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Parthenolide inhibits ERK and AP-1 which are dysregulated and contribute to excessive IL-8 expression and secretion in cystic_fibrosis cells .
18088190	0	Parthenolide	0,12	NF-kappaB	82,91	Parthenolide	NF-kappaB	MESH:C002669	4790	Chemical	Gene	sensitizes|nsubj|START_ENTITY sensitizes|nmod|cell cell|acl|killing killing|nmod|inhibition inhibition|nmod|repair repair|amod|END_ENTITY	Parthenolide sensitizes cells to X-ray-induced cell killing through inhibition of NF-kappaB and split-dose repair .
18277052	0	Parthenolide	0,12	NF-kappaB	66,75	Parthenolide	NF-kappaB	MESH:C002669	4790	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|affecting affecting|dobj|END_ENTITY	Parthenolide induces apoptosis in glioblastomas without affecting NF-kappaB .
17200339	0	Parthenolide	0,12	Nuclear_Factor-kappaB	37,58	Parthenolide	Nuclear Factor-kappaB	MESH:C002669	4790	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Parthenolide , a natural inhibitor of Nuclear_Factor-kappaB , inhibits lung colonization of murine osteosarcoma cells .
21413021	0	Parthenolide	0,12	TRAIL	58,63	Parthenolide	TRAIL	MESH:C002669	8743	Chemical	Gene	sensitizes|nsubj|START_ENTITY sensitizes|xcomp|END_ENTITY	Parthenolide sensitizes hepatocellular_carcinoma cells to TRAIL by inducing the expression of death receptors through inhibition of STAT3 activation .
25502339	0	Parthenolide	0,12	TRAIL	64,69	Parthenolide	TRAIL	MESH:C002669	8743	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|advcl|END_ENTITY	Parthenolide enhances sensitivity of colorectal_cancer cells to TRAIL by inducing death_receptor_5 and promotes TRAIL-induced apoptosis .
20890664	0	Pasireotide	0,11	IGF-I	16,21	Pasireotide	IGF-I	MESH:C517782	3479	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Pasireotide , an IGF-I action inhibitor , prevents growth_hormone and estradiol-induced mammary hyperplasia .
26990064	0	Pasireotide	0,11	Multiple_Endocrine_Neoplasia_type_1	23,58	Pasireotide	Multiple Endocrine Neoplasia type 1	MESH:C517782	17283(Tax:10090)	Chemical	Gene	therapy|amod|START_ENTITY therapy|nmod|END_ENTITY	Pasireotide therapy of Multiple_Endocrine_Neoplasia_type_1 -LRB- MEN1 -RRB- - associated neuroendocrine_tumors -LRB- NETs -RRB- in female mice deleted for an Men1 allele -LRB- Men1 -LRB- + / - -RRB- -RRB- improves survival and reduces tumor progression .
21673137	0	Pasireotide	0,11	somatostatin	53,65	Pasireotide	somatostatin	MESH:C517782	6750	Chemical	Gene	START_ENTITY|appos|analogue analogue|compound|END_ENTITY	Pasireotide -LRB- SOM230 -RRB- , a novel multireceptor-targeted somatostatin analogue , is well tolerated when administered as a continuous 7-day subcutaneous infusion in healthy male volunteers .
22481092	0	Paxillin	0,8	Erk	45,48	Paxillin	Erk	null	5594	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Paxillin phosphorylation and complexing with Erk and FAK are regulated by PLD activity in MDA-MB-231 cells .
22865050	0	Paxillin	0,8	JNK	28,31	Paxillin	JNK	null	5599	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Paxillin phosphorylation by JNK and p38 is required for NFAT activation .
9488700	0	Paxillin	0,8	Lck	46,49	Paxillin	Lck	null	3932	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Paxillin phosphorylation and association with Lck and Pyk2 in anti-CD3 - or anti-CD45-stimulated T cells .
26947183	0	PazePC	26,32	Bax	89,92	PazePC	Bax	CHEBI:61817	581	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	The oxidized phospholipid PazePC promotes permeabilization of mitochondrial membranes by Bax .
21081656	0	Pazopanib	0,9	B-Raf	40,45	Pazopanib	B-Raf	MESH:C516667	673	Chemical	Gene	reveals|nsubj|START_ENTITY reveals|dobj|role role|nmod|END_ENTITY	Pazopanib reveals a role for tumor cell B-Raf in the prevention of HER2 + breast_cancer brain metastasis .
19037839	0	Pazopanib	0,9	VEGF	13,17	Pazopanib	VEGF	MESH:C516667	7422	Chemical	Gene	tyrosine|advmod|START_ENTITY tyrosine|nsubj|receptor receptor|compound|END_ENTITY	Pazopanib , a VEGF receptor tyrosine kinase inhibitor for cancer therapy .
14514953	0	Pb	25,27	StAR	71,75	Pb	StAR	null	25557(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	The effects of low-level Pb on steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- in the prepubertal rat ovary .
25044211	0	Pb	40,42	beta-catenin	14,26	Pb	beta-catenin	null	12387(Tax:10090)	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Inhibition of beta-catenin signaling by Pb leads to incomplete fracture healing .
18497167	0	Pd	59,61	CO2	37,40	Pd	CO2	null	717	Chemical	Gene	decomposition|nmod|START_ENTITY decomposition|nmod|END_ENTITY	Efficient catalytic decomposition of CO2 to CO and O2 over Pd / mixed-conducting oxide catalyst in an oxygen-permeable membrane reactor .
25961806	0	Pediocin	4,12	PA-1	13,17	Pediocin	PA-1	null	79447	Chemical	Gene	Protein|compound|START_ENTITY Protein|compound|END_ENTITY	The Pediocin PA-1 Accessory Protein Ensures Correct Disulfide Bond Formation in the Antimicrobial Peptide Pediocin PA-1 .
26882613	0	Peimine	11,18	ERCC1	22,27	Peimine	ERCC1	MESH:C014242	2067	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|mRNA mRNA|compound|END_ENTITY	-LSB- Effect of Peimine on ERCC1 mRNA and LRP Expressions of A549/DDP Multidrug Resistance Cell Line -RSB- .
23419638	0	Pelargonidin	0,12	AhR	27,30	Pelargonidin	AhR	MESH:C066957	196	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Pelargonidin activates the AhR and induces CYP1A1 in primary human hepatocytes and human cancer cell lines HepG2 and LS174T .
19879665	0	Pelargonium	2,13	ARGONAUTE4	14,24	Pelargonium	ARGONAUTE4	null	817246(Tax:3702)	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	A Pelargonium ARGONAUTE4 gene shows organ-specific expression and differences in RNA and protein levels .
17463156	0	Peloruside_A	0,12	tumor_necrosis_factor-alpha	59,86	Peloruside A	tumor necrosis factor-alpha	MESH:C414085	21926(Tax:10090)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|production production|amod|END_ENTITY	Peloruside_A , an antimitotic agent , specifically decreases tumor_necrosis_factor-alpha production by lipopolysaccharide-stimulated murine macrophages .
25123845	0	Penta-O-galloyl-b-D-glucose	0,27	eIF3i	51,56	Penta-O-galloyl-b-D-glucose	eIF3i	null	8668	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Penta-O-galloyl-b-D-glucose suppresses EGF-induced eIF3i expression through inhibition of the PI3K/AKT/mTOR pathway in prostate_cancer cells .
26447340	0	Penta-l-lysine	0,14	Tissue_Plasminogen_Activator	64,92	Penta-l-lysine	Tissue Plasminogen Activator	null	100128998	Chemical	Gene	Activity|compound|START_ENTITY Activity|nmod|END_ENTITY	Penta-l-lysine Potentiates Fibrin-Independent Activity of Human Tissue_Plasminogen_Activator .
25938234	0	Pentacyclic_Triterpenoids	0,25	IKKb	34,38	Pentacyclic Triterpenoids	IKKb	CHEBI:25872	16150(Tax:10090)	Chemical	Gene	Activation|compound|START_ENTITY Activation|compound|END_ENTITY	Pentacyclic_Triterpenoids Inhibit IKKb Mediated Activation of NF-kB Pathway : In Silico and In Vitro Evidences .
16637063	0	Pentagalloylglucose	0,19	estrogen_receptor_alpha	29,52	Pentagalloylglucose	estrogen receptor alpha	MESH:C435084	2099	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Pentagalloylglucose inhibits estrogen_receptor_alpha by lysosome-dependent depletion and modulates ErbB/PI3K/Akt pathway in human breast_cancer MCF-7 cells .
15711592	0	Pentamidine	0,11	hERG	20,24	Pentamidine	hERG	MESH:D010419	2078	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|amod|END_ENTITY	Pentamidine reduces hERG expression to prolong the QT interval .
2867680	0	Pentobarbital	0,13	pancreatic_polypeptide	45,67	Pentobarbital	pancreatic polypeptide	MESH:D010424	490944(Tax:9615)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|release release|amod|END_ENTITY	Pentobarbital suppresses basal and reflexive pancreatic_polypeptide release in dogs .
18462022	0	Pentose_Phosphate	41,58	Glucose-6-Phosphate_Dehydrogenase	0,33	Pentose Phosphate	Glucose-6-Phosphate Dehydrogenase	null	2539	Chemical	Gene	Pathway|compound|START_ENTITY END_ENTITY|nmod|Pathway	Glucose-6-Phosphate_Dehydrogenase in the Pentose_Phosphate Pathway Is Localized in Vanadocytes of the Vanadium-Rich Ascidian , Ascidia sydneiensis samea .
1504408	0	Pentostatin	0,11	adenosine_deaminase	16,35	Pentostatin	adenosine deaminase	MESH:D015649	100	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Pentostatin : an adenosine_deaminase inhibitor for the treatment of hairy_cell_leukemia .
10741905	0	Pentoxifylline	0,14	ICAM-1	24,30	Pentoxifylline	ICAM-1	MESH:D010431	3383	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Pentoxifylline inhibits ICAM-1 expression and chemokine production induced by proinflammatory cytokines in human pulmonary epithelial cells .
20569121	0	Pentoxifylline	0,14	ICAM-1	59,65	Pentoxifylline	ICAM-1	MESH:D010431	25464(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|intercellular_adhesion_molecule-1 intercellular_adhesion_molecule-1|appos|END_ENTITY	Pentoxifylline inhibits intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- and lung_injury in experimental phosgene-exposure rats .
11422205	0	Pentoxifylline	0,14	IL-18	73,78	Pentoxifylline	IL-18	MESH:D010431	16173(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	Pentoxifylline inhibits the synthesis and IFN-gamma-inducing activity of IL-18 .
7835945	0	Pentoxifylline	0,14	IL-1_beta	53,62	Pentoxifylline	IL-1 beta	MESH:D010431	3553	Chemical	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	Pentoxifylline in vivo down-regulates the release of IL-1_beta , IL-6 , IL-8 and tumour necrosis factor-alpha by human peripheral blood mononuclear cells .
23639230	0	Pentoxifylline	0,14	STAT3	76,81	Pentoxifylline	STAT3	MESH:D010431	6774	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	Pentoxifylline inhibits melanoma_tumor growth and angiogenesis by targeting STAT3 signaling pathway .
12593855	0	Pentoxifylline	0,14	TNF-alpha	46,55	Pentoxifylline	TNF-alpha	MESH:D010431	21926(Tax:10090)	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|toxicity toxicity|amod|END_ENTITY	Pentoxifylline protects L929 fibroblasts from TNF-alpha toxicity via the induction of heme_oxygenase-1 .
7803190	0	Pentoxifylline	0,14	TNF-alpha	83,92	Pentoxifylline	TNF-alpha	MESH:D010431	7124	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Pentoxifylline enhances sensitivity of a human ovarian_cancer cell line -LRB- OVC-8 -RRB- to TNF-alpha .
9329035	0	Pentoxifylline	0,14	TNF-alpha	30,39	Pentoxifylline	TNF-alpha	MESH:D010431	100009088(Tax:9986)	Chemical	Gene	suppression|amod|START_ENTITY suppression|nmod|END_ENTITY	Pentoxifylline suppression of TNF-alpha mediated axonal_degeneration in the rabbit optic nerve .
9486396	0	Pentoxifylline	0,14	TNF-alpha	76,85	Pentoxifylline	TNF-alpha	MESH:D010431	7124	Chemical	Gene	decreases|amod|START_ENTITY necrosis|nsubj|decreases necrosis|dobj|production production|appos|END_ENTITY	Pentoxifylline decreases in vivo and in vitro tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- production in lepromatous_leprosy patients with erythema_nodosum_leprosum -LRB- ENL -RRB- .
9927365	0	Pentoxifylline	0,14	TNF-alpha	24,33	Pentoxifylline	TNF-alpha	MESH:D010431	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Pentoxifylline inhibits TNF-alpha production from human alveolar macrophages .
20569121	0	Pentoxifylline	0,14	intercellular_adhesion_molecule-1	24,57	Pentoxifylline	intercellular adhesion molecule-1	MESH:D010431	25464(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Pentoxifylline inhibits intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- and lung_injury in experimental phosgene-exposure rats .
15205554	0	Pentoxifylline	0,14	tumor_necrosis_factor	33,54	Pentoxifylline	tumor necrosis factor	MESH:D010431	103694380	Chemical	Gene	ameliorates|nsubj|START_ENTITY ameliorates|dobj|expression expression|compound|END_ENTITY	Pentoxifylline ameliorates renal tumor_necrosis_factor expression , sodium retention , and renal_hypertrophy in diabetic rats .
2233123	0	Pentoxifylline	0,14	tumor_necrosis_factor	57,78	Pentoxifylline	tumor necrosis factor	MESH:D010431	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Pentoxifylline inhibits lipopolysaccharide-induced serum tumor_necrosis_factor and mortality .
15467217	0	Pentoxifylline	0,14	tumor_necrosis_factor-alpha	24,51	Pentoxifylline	tumor necrosis factor-alpha	MESH:D010431	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|synthesis synthesis|amod|END_ENTITY	Pentoxifylline inhibits tumor_necrosis_factor-alpha induced synthesis of complement component C3 in human endothelial cells .
8035043	0	Pentoxifylline	0,14	tumor_necrosis_factor-alpha	40,67	Pentoxifylline	tumor necrosis factor-alpha	MESH:D010431	7124	Chemical	Gene	aggravates|nsubj|START_ENTITY aggravates|nmod|secretion secretion|amod|END_ENTITY	Pentoxifylline aggravates impairment in tumor_necrosis_factor-alpha secretion and increases mycobacterial load in macrophages from AIDS patients with disseminated Mycobacterium_avium-intracellulare complex infection .
8132735	0	Pentoxifylline	0,14	tumor_necrosis_factor-alpha	124,151	Pentoxifylline	tumor necrosis factor-alpha	MESH:D010431	7124	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|advcl|inhibiting inhibiting|dobj|secretion secretion|amod|END_ENTITY	Pentoxifylline suppresses interleukin-2-mediated activation of immature human natural killer cells by inhibiting endogenous tumor_necrosis_factor-alpha secretion .
9052855	0	Pentoxifylline	0,14	tumor_necrosis_factor-alpha	76,103	Pentoxifylline	tumor necrosis factor-alpha	MESH:D010431	24835(Tax:10116)	Chemical	Gene	inhibit|advmod|START_ENTITY inhibit|dobj|production production|amod|END_ENTITY	Pentoxifylline , cyclosporine_A and taurolidine inhibit endotoxin-stimulated tumor_necrosis_factor-alpha production in rat mesangial cell cultures .
21968012	0	Pentoxifylline	0,14	tumor_necrosis_factor_alpha	41,68	Pentoxifylline	tumor necrosis factor alpha	MESH:D010431	7124	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|levels levels|nmod|END_ENTITY	Pentoxifylline decreases serum levels of tumor_necrosis_factor_alpha , interleukin_6 and C-reactive_protein in hemodialysis patients : results of a randomized double-blind , controlled clinical trial .
24486700	0	Pentyl-4-yn-VPA	0,15	histone_deacetylase	19,38	Pentyl-4-yn-VPA	histone deacetylase	null	9734	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Pentyl-4-yn-VPA , a histone_deacetylase inhibitor , ameliorates_deficits in social behavior and cognition in a rodent model of autism_spectrum_disorders .
11941005	0	Pentylenetetrazol	22,39	Prolactin	0,9	Pentylenetetrazol	Prolactin	MESH:D010433	5617	Chemical	Gene	Response|nmod|START_ENTITY Response|compound|END_ENTITY	Prolactin Response to Pentylenetetrazol -LRB- Cardiazol -RRB- Convulsive Therapy .
17404064	0	Peonidin	0,8	COX-2	40,45	Peonidin	COX-2	MESH:C473205	19225(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Peonidin inhibits phorbol-ester-induced COX-2 expression and transformation in JB6 P + cells by blocking phosphorylation of ERK-1_and _ -2 .
21190116	0	Peoniflorin	0,11	tumor_necrosis_factor-a	23,46	Peoniflorin	tumor necrosis factor-a	MESH:C015423	7124	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|production production|amod|END_ENTITY	Peoniflorin suppresses tumor_necrosis_factor-a induced chemokine production in human dermal microvascular endothelial cells by blocking nuclear factor-kB and ERK pathway .
3543358	0	Pepstatin	0,9	renin	29,34	Pepstatin	renin	MESH:C031375	100524822	Chemical	Gene	analogues|nsubj|START_ENTITY analogues|nmod|inhibitors inhibitors|compound|END_ENTITY	Pepstatin analogues as novel renin inhibitors .
6759112	0	Pepstatin	0,9	renin	46,51	Pepstatin	renin	MESH:C031375	5972	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	Pepstatin inhibition of proteinase-free human renin .
12832100	0	Peptides	0,8	chromogranin_A	39,53	Peptides	chromogranin A	MESH:D010455	281070(Tax:9913)	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Peptides from the N-terminal domain of chromogranin_A -LRB- vasostatins -RRB- exert negative inotropic effects in the isolated frog heart .
9873373	0	Peptidyl_beta-homo-aspartals	0,28	interleukin-1_beta_converting_enzyme	53,89	Peptidyl beta-homo-aspartals	interleukin-1 beta converting enzyme	null	834	Chemical	Gene	START_ENTITY|dep|inhibitors inhibitors|nmod|END_ENTITY	Peptidyl_beta-homo-aspartals : specific inhibitors of interleukin-1_beta_converting_enzyme and its homologues -LRB- caspases -RRB- .
1348906	0	Peptone	0,7	gastrin	19,26	Peptone	gastrin	null	25320(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|compound|END_ENTITY	Peptone stimulates gastrin secretion from the stomach by activating bombesin/GRP and cholinergic neurons .
27065996	0	Peramivir	0,9	Neuraminidase	31,44	Peramivir	Neuraminidase	MESH:C414210	4758	Chemical	Gene	START_ENTITY|dep|Inhibitor Inhibitor|compound|END_ENTITY	Peramivir : A Novel Intravenous Neuraminidase Inhibitor for Treatment of Acute Influenza_Infections .
20516360	0	Peramivir	0,9	neuraminidase	26,39	Peramivir	neuraminidase	MESH:C414210	4758	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Peramivir : an intravenous neuraminidase inhibitor for the treatment of 2009 H1N1 influenza .
25629811	0	Peramivir	0,9	neuraminidase	27,40	Peramivir	neuraminidase	MESH:C414210	4758	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Peramivir -LRB- Rapivab -RRB- : an IV neuraminidase inhibitor for treatment of influenza .
26153242	0	Peramivir	0,9	neuraminidase	27,40	Peramivir	neuraminidase	MESH:C414210	4758	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Peramivir : an intravenous neuraminidase inhibitor .
19904008	0	Perazine	0,8	cytochrome_P450_isoenzyme_1A2	59,88	Perazine	cytochrome P450 isoenzyme 1A2	MESH:D010464	1544	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Perazine at therapeutic drug concentrations inhibits human cytochrome_P450_isoenzyme_1A2 -LRB- CYP1A2 -RRB- and caffeine metabolism -- an in vitro study .
17344663	0	Perfluorocarbon	0,15	interleukin-8	71,84	Perfluorocarbon	interleukin-8	null	3576	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|release release|amod|END_ENTITY	Perfluorocarbon suppresses lipopolysaccharide - and alpha-toxin-induced interleukin-8 release from alveolar epithelial cells .
26004316	0	Perfluorooctane_sulfonate	0,25	TNF-a	74,79	Perfluorooctane sulfonate	TNF-a	MESH:C076994	7124	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|nmod|END_ENTITY	Perfluorooctane_sulfonate mediates microglial activation and secretion of TNF-a through Ca -LRB- 2 + -RRB- - dependent PKC-NF - B signaling .
25516096	0	Perfluorooctanoic_acid	0,22	peroxisome_proliferator-activated_receptor_y	32,76	Perfluorooctanoic acid	peroxisome proliferator-activated receptor y	MESH:C023036	5468	Chemical	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Perfluorooctanoic_acid binds to peroxisome_proliferator-activated_receptor_y and promotes adipocyte differentiation in 3T3-L1 adipocytes .
10084498	0	Perfluorooctyl_bromide	0,22	mucin	47,52	Perfluorooctyl bromide	mucin	MESH:C003072	100508689	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|compound|END_ENTITY	Perfluorooctyl_bromide -LRB- perflubron -RRB- stimulates mucin secretion in the ferret trachea .
3987929	0	Pergolide_mesylate	0,18	prolactin	45,54	Pergolide mesylate	prolactin	MESH:D010479	5617	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|compound|END_ENTITY	Pergolide_mesylate inhibits exercise-induced prolactin release in man .
26368306	0	Perhexiline	0,11	KLF14	22,27	Perhexiline	KLF14	MESH:D010480	619665(Tax:10090)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Perhexiline activates KLF14 and reduces atherosclerosis by modulating ApoA-I production .
6241566	0	Perhexiline	0,11	myosin	39,45	Perhexiline	myosin	MESH:D010480	79784	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Perhexiline directly inhibits arterial myosin phosphorylation and stimulates cardiac myofibrillar ATPase activity .
18687514	0	Perifosine	0,10	AKT	84,87	Perifosine	AKT	MESH:C105905	207	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|blockade blockade|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Perifosine inhibits growth of human experimental endometrial_cancers by blockade of AKT phosphorylation .
23877012	0	Perifosine	0,10	AKT	15,18	Perifosine	AKT	MESH:C105905	207	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Perifosine , an AKT inhibitor , modulates ovarian_cancer cell line sensitivity to cisplatin-induced growth_arrest .
14617782	9	Perifosine	1360,1370	Akt	1512,1515	Perifosine	Akt	MESH:C105905	207	Chemical	Gene	affect|nsubj|START_ENTITY affect|nmod|concentrations concentrations|acl|inhibiting inhibiting|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Perifosine does not directly affect phosphoinositide 3-kinase -LRB- PI3K -RRB- , phosphoinositide-dependent kinase 1 , or Akt activity at concentrations inhibiting Akt phosphorylation and membrane localization .
19216841	0	Perifosine	0,10	Akt	30,33	Perifosine	Akt	MESH:C105905	207	Chemical	Gene	START_ENTITY|dep|update update|nmod|inhibitor inhibitor|compound|END_ENTITY	Perifosine : update on a novel Akt inhibitor .
20842425	0	Perifosine	0,10	Akt	111,114	Perifosine	Akt	MESH:C105905	207	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|blockade blockade|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Perifosine induces cell cycle arrest and apoptosis in human hepatocellular_carcinoma cell lines by blockade of Akt phosphorylation .
22512706	0	Perifosine	0,10	Akt	61,64	Perifosine	Akt	MESH:C105905	207	Chemical	Gene	START_ENTITY|appos|agent agent|nmod|pathway pathway|compound|END_ENTITY	Perifosine , an oral , anti-cancer agent and inhibitor of the Akt pathway : mechanistic actions , pharmacodynamics , pharmacokinetics , and clinical activity .
22825337	0	Perifosine	0,10	GSK3b	68,73	Perifosine	GSK3b	MESH:C105905	2932	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|activation activation|nmod|END_ENTITY	Perifosine enhances mTORC1-targeted cancer therapy by activation of GSK3b in NSCLC cells .
19010914	0	Perifosine	78,88	TRAIL	49,54	Perifosine	TRAIL	MESH:C105905	8743	Chemical	Gene	activity|nmod|START_ENTITY activity|nmod|END_ENTITY	Synergistic proapoptotic activity of recombinant TRAIL plus the Akt inhibitor Perifosine in acute_myelogenous_leukemia cells .
19920197	0	Perifosine	0,10	mammalian_target_of_rapamycin	20,49	Perifosine	mammalian target of rapamycin	MESH:C105905	2475	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Perifosine inhibits mammalian_target_of_rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy .
20130960	0	Perifosine	0,10	p53	104,107	Perifosine	p53	MESH:C105905	7157	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Perifosine selectively induces cell cycle block and modulates retinoblastoma and E2F1 protein levels in p53 mutated leukemic cell lines .
9434775	0	Perillic_acid	0,13	IL-2	45,49	Perillic acid	IL-2	MESH:C078706	3558	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	Perillic_acid inhibits Ras/MAP kinase-driven IL-2 production in human T lymphocytes .
16029925	0	Perillyl_alcohol	0,16	androgen_receptor	61,78	Perillyl alcohol	androgen receptor	MESH:C032208	367	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Perillyl_alcohol inhibits the expression and function of the androgen_receptor in human prostate_cancer cells .
12043242	0	Perindopril	163,174	ACE	21,24	Perindopril	ACE	MESH:D020913	1636	Chemical	Gene	-RSB-|compound|START_ENTITY Polymorphism|nmod|-RSB- Polymorphism|nmod|gene gene|compound|END_ENTITY	-LSB- Polymorphism of the ACE gene , structural-functional state of the left ventricle in patients with post-infarction cardiac_failure and effects of the ACE-inhibitor Perindopril -RSB- .
19421649	0	Perindopril	0,11	ACE	57,60	Perindopril	ACE	MESH:D020913	1636	Chemical	Gene	START_ENTITY|parataxis|support support|dobj|effect effect|compound|END_ENTITY	Perindopril : do randomised , controlled trials support an ACE inhibitor class effect ?
2559047	0	Perindopril	32,43	ACE	161,164	Perindopril	ACE	MESH:D020913	100009274(Tax:9986)	Chemical	Gene	inhibitor|amod|START_ENTITY sites|nmod|inhibitor sites|dep|evidence evidence|nmod|localization localization|nmod|END_ENTITY	High affinity binding sites for Perindopril a new inhibitor of angiotensin-I-converting_enzyme -LRB- ACE -RRB- in the rabbit kidney : possible evidence for localization of ACE in endothelial structures and in glomerular mesangium .
2559047	0	Perindopril	32,43	ACE	96,99	Perindopril	ACE	MESH:D020913	100009274(Tax:9986)	Chemical	Gene	inhibitor|amod|START_ENTITY sites|nmod|inhibitor sites|nmod|angiotensin-I-converting_enzyme angiotensin-I-converting_enzyme|appos|END_ENTITY	High affinity binding sites for Perindopril a new inhibitor of angiotensin-I-converting_enzyme -LRB- ACE -RRB- in the rabbit kidney : possible evidence for localization of ACE in endothelial structures and in glomerular mesangium .
21593435	0	Perindopril	0,11	angiotensin-converting_enzyme	32,61	Perindopril	angiotensin-converting enzyme	MESH:D020913	11421(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Perindopril , a centrally active angiotensin-converting_enzyme inhibitor , prevents cognitive_impairment in mouse models of Alzheimer 's _ disease .
3038395	0	Perindopril	0,11	angiotensin_converting_enzyme	19,48	Perindopril	angiotensin converting enzyme	MESH:D020913	1636	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Perindopril , a new angiotensin_converting_enzyme inhibitor -- clinical pharmacological studies in healthy subjects .
24590580	0	Perindopril-Indapamide	145,167	rISk	192,196	Perindopril-Indapamide	rISk	null	25471(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|patients patients|compound|END_ENTITY	Antihypertensive efficacy of triple combination perindopril/indapamide plus amlodipine in high-risk hypertensives : results of the PIANIST study -LRB- Perindopril-Indapamide plus AmlodipiNe in high rISk hyperTensive patients -RRB- .
22735632	0	Periostin	0,9	PI3K/AKT	44,52	Periostin	PI3K/AKT	null	5293;207	Chemical	Gene	activates|nsubj|START_ENTITY activates|nmod|END_ENTITY	Periostin activates integrin a5b1 through a PI3K/AKT - dependent pathway in invasion of cholangiocarcinoma .
26627163	0	Permethyloligosilane	36,56	Sin	90,93	Permethyloligosilane	Sin	null	10278	Chemical	Gene	Ions|compound|START_ENTITY Ions|nmod|END_ENTITY	Structures and Electronic States of Permethyloligosilane Radical Ions with All-Trans Form Sin -LRB- CH3 -RRB- 2n +2 -LRB- -RRB- -LRB- n = 2-6 -RRB- : A Density Functional Theory Study .
10576698	0	Peroxides	0,9	cysteine_protease	74,91	Peroxides	cysteine protease	MESH:D010545	1508	Chemical	Gene	START_ENTITY|dep|inhibition inhibition|nmod|END_ENTITY	Peroxides as oxidative enzyme inhibitors : mechanism-based inhibition of a cysteine_protease by an amino_acid ozonide .
23583568	0	Peroxidized_unsaturated_fatty_acids	0,35	Toll-like_receptor_4	46,66	Peroxidized unsaturated fatty acids	Toll-like receptor 4	null	281536(Tax:9913)	Chemical	Gene	stimulate|nsubj|START_ENTITY stimulate|dobj|END_ENTITY	Peroxidized_unsaturated_fatty_acids stimulate Toll-like_receptor_4 signaling in endothelial cells .
14757124	0	Peroxovanadate	0,14	alpha_1B-adrenoceptor	23,44	Peroxovanadate	alpha 1B-adrenoceptor	MESH:C069276	147	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|amod|END_ENTITY	Peroxovanadate induces alpha_1B-adrenoceptor phosphorylation and association with protein kinase C. Peroxovanadate induced a marked increase in the phosphorylation state of alpha -LRB- 1B -RRB- - adrenoceptors .
15850570	0	Peroxynitrite	0,13	ERK	24,27	Peroxynitrite	ERK	MESH:D030421	5594	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Peroxynitrite activates ERK via Raf-1 and MEK , independently from EGF_receptor and p21Ras in H9C2 cardiomyocytes .
11163539	0	Peroxynitrite	0,13	GADD34	22,28	Peroxynitrite	GADD34	MESH:D030421	23645	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Peroxynitrite induces GADD34 , 45 , and 153 VIA p38 MAPK in human neuroblastoma SH-SY5Y cells .
16962933	0	Peroxynitrite	0,13	HO-1	22,26	Peroxynitrite	HO-1	MESH:D030421	24451(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Peroxynitrite induces HO-1 expression via PI3K/Akt-dependent activation of NF-E2-related_factor_2 in PC12 cells .
11358991	0	Peroxynitrite	0,13	IL-8	40,44	Peroxynitrite	IL-8	MESH:D030421	3576	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|dobj|expression expression|compound|END_ENTITY	Peroxynitrite mediates cytokine-induced IL-8 gene expression and production by human leukocytes .
9820546	0	Peroxynitrite	0,13	IL-8	23,27	Peroxynitrite	IL-8	MESH:D030421	3576	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|dobj|expression expression|compound|END_ENTITY	Peroxynitrite mediates IL-8 gene expression and production in lipopolysaccharide-stimulated human whole blood .
9741582	0	Peroxynitrite	0,13	MnSOD	24,29	Peroxynitrite	MnSOD	MESH:D030421	6648	Chemical	Gene	modulates|amod|START_ENTITY END_ENTITY|nsubj|modulates	Peroxynitrite modulates MnSOD gene expression in lung epithelial cells .
10827005	0	Peroxynitrite	0,13	TNF-alpha	28,37	Peroxynitrite	TNF-alpha	MESH:D030421	21926(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Peroxynitrite production by TNF-alpha and IL-1beta : implication for suppression of osteoblastic differentiation .
16257644	0	Peroxynitrite	0,13	VEGF	24,28	Peroxynitrite	VEGF	MESH:D030421	7422	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Peroxynitrite increases VEGF expression in vascular endothelial cells via STAT3 .
17384142	0	Peroxynitrite	0,13	VEGF	23,27	Peroxynitrite	VEGF	MESH:D030421	22339(Tax:10090)	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|dobj|signal signal|nmod:poss|END_ENTITY	Peroxynitrite mediates VEGF 's angiogenic signal and function via a nitration-independent mechanism in endothelial cells .
10801894	0	Peroxynitrite	0,13	epidermal_growth_factor_receptor	26,58	Peroxynitrite	epidermal growth factor receptor	MESH:D030421	24329(Tax:10116)	Chemical	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Peroxynitrite targets the epidermal_growth_factor_receptor , Raf-1 , and MEK independently to activate MAPK .
14714624	0	Peroxynitrite	0,13	epidermal_growth_factor_receptor	23,55	Peroxynitrite	epidermal growth factor receptor	MESH:D030421	1956	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Peroxynitrite inhibits epidermal_growth_factor_receptor signaling in Caco-2 cells .
26406004	0	Peroxynitrite	0,13	fibrinogen	22,32	Peroxynitrite	fibrinogen	MESH:D030421	2244	Chemical	Gene	induced|compound|START_ENTITY END_ENTITY|nsubj|induced	Peroxynitrite induced fibrinogen site identification .
9005440	0	Peroxynitrite	0,13	glutathione_reductase	30,51	Peroxynitrite	glutathione reductase	MESH:D030421	2936	Chemical	Gene	modification|amod|START_ENTITY modification|nmod|END_ENTITY	Peroxynitrite modification of glutathione_reductase : modeling studies and kinetic evidence suggest the modification of tyrosines at the glutathione_disulfide binding site .
10215613	0	Peroxynitrite	0,13	haem_oxygenase-1	22,38	Peroxynitrite	haem oxygenase-1	MESH:D030421	513221(Tax:9913)	Chemical	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Peroxynitrite induces haem_oxygenase-1 in vascular endothelial cells : a link to apoptosis .
11788351	0	Peroxynitrite	0,13	iNOS	24,28	Peroxynitrite	iNOS	MESH:D030421	4843	Chemical	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	Peroxynitrite increases iNOS through NF-kappaB and decreases prostacyclin synthase in endothelial cells .
16214107	0	Peroxynitrite	0,13	myeloperoxidase	81,96	Peroxynitrite	myeloperoxidase	MESH:D030421	4353	Chemical	Gene	efficiently|compound|START_ENTITY mediates|nsubj|efficiently mediates|dobj|interconversion interconversion|nmod|intermediates intermediates|nmod|END_ENTITY	Peroxynitrite efficiently mediates the interconversion of redox intermediates of myeloperoxidase .
11253164	0	Peroxynitrite	0,13	ornithine_decarboxylase	39,62	Peroxynitrite	ornithine decarboxylase	MESH:D030421	24609(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	Peroxynitrite inhibits the activity of ornithine_decarboxylase .
11062076	0	Peroxynitrite	0,13	phosphoinositide_3-kinase	28,53	Peroxynitrite	phosphoinositide 3-kinase	MESH:D030421	5293	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|pathway pathway|amod|END_ENTITY	Peroxynitrite activates the phosphoinositide_3-kinase / Akt pathway in human skin primary fibroblasts .
10575026	0	Peroxynitrite	0,13	tyrosine_hydroxylase	30,50	Peroxynitrite	tyrosine hydroxylase	MESH:D030421	7054	Chemical	Gene	inactivation|amod|START_ENTITY inactivation|nmod|END_ENTITY	Peroxynitrite inactivation of tyrosine_hydroxylase : mediation by sulfhydryl oxidation , not tyrosine nitration .
3091271	0	Pertussigen	0,11	interferon-gamma	36,52	Pertussigen	interferon-gamma	MESH:D037342	15978(Tax:10090)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|amod|END_ENTITY	Pertussigen enhances antigen-driven interferon-gamma production by sensitized lymphoid cells .
9607326	0	Pervanadate	0,11	mitogen-activated_protein_kinase_kinase-1	21,62	Pervanadate	mitogen-activated protein kinase kinase-1	MESH:C076715	101008394	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Pervanadate inhibits mitogen-activated_protein_kinase_kinase-1 in a p38MAPK-dependent manner .
17746179	0	Phaseolin	0,9	bean	20,24	Phaseolin	bean	null	146227	Chemical	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Phaseolin gene from bean is expressed after transfer to sunflower via tumor-inducing plasmid vectors .
10586122	0	Phe	19,22	leptin_receptor	33,48	Phe	leptin receptor	CHEBI:28044	24536(Tax:10116)	Chemical	Gene	mutations|compound|START_ENTITY mutations|compound|END_ENTITY	Analysis of Tyr to Phe and fa/fa leptin_receptor mutations in the PC12 cell line .
11128715	0	Phe	2,5	thyrotropin_receptor	10,30	Phe	thyrotropin receptor	CHEBI:28044	7253	Chemical	Gene	mutation|compound|START_ENTITY mutation|compound|END_ENTITY	A Phe 486 thyrotropin_receptor mutation in an autonomously functioning follicular_carcinoma that was causing hyperthyroidism .
6150529	0	Phe-4-somatostatin	53,71	growth_hormone	14,28	Phe-4-somatostatin	growth hormone	null	2688	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of growth_hormone and glucagon release by Phe-4-somatostatin in patients with acromegaly .
6096340	0	Phenacein	0,9	angiotensin-converting_enzyme	14,43	Phenacein	angiotensin-converting enzyme	MESH:C043271	1636	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Phenacein -- an angiotensin-converting_enzyme inhibitor produced by a streptomycete .
22015741	0	Phencyclidine	0,13	NR2A	34,38	Phencyclidine	NR2A	MESH:D010622	24409(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY increases|nsubj|treatment increases|dobj|expression expression|compound|END_ENTITY	Phencyclidine treatment increases NR2A and NR2B N-methyl-D-aspartate receptor subunit expression in rats .
2938052	0	Phencyclidine	0,13	PCP	15,18	Phencyclidine	PCP	MESH:D010622	5547	Chemical	Gene	_|compound|START_ENTITY _|appos|END_ENTITY	Phencyclidine _ -LRB- PCP -RRB- _ abuse .
24615983	0	Phencyclidine	0,13	brain-derived_neurotrophic_factor	49,82	Phencyclidine	brain-derived neurotrophic factor	MESH:D010622	627	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|mRNA mRNA|nmod|END_ENTITY	Phencyclidine rapidly decreases neuronal mRNA of brain-derived_neurotrophic_factor .
8959289	0	Phencyclidine	0,13	neuropeptide_Y	48,62	Phencyclidine	neuropeptide Y	MESH:D010622	24604(Tax:10116)	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|concentrations concentrations|nmod|END_ENTITY	Phencyclidine alters regional concentrations of neuropeptide_Y and peptide_YY in rat brain .
22174033	0	Phenethyl_isothiocyanate	0,24	aryl_hydrocarbon_receptor	87,112	Phenethyl isothiocyanate	aryl hydrocarbon receptor	MESH:C058305	25690(Tax:10116)	Chemical	Gene	antagonist|nsubj|START_ENTITY antagonist|nmod|END_ENTITY	Phenethyl_isothiocyanate , a naturally occurring phytochemical , is an antagonist of the aryl_hydrocarbon_receptor .
7024393	0	Phenformin	0,10	insulin	26,33	Phenformin	insulin	MESH:D010629	3630	Chemical	Gene	stimulation|compound|START_ENTITY stimulation|nmod|END_ENTITY	Phenformin stimulation of insulin binding to human cultured lymphocytes .
23652203	0	Phenobarbital	0,13	CAR	80,83	Phenobarbital	CAR	MESH:D010634	9970	Chemical	Gene	activates|nsubj|START_ENTITY activates|dep|END_ENTITY	Phenobarbital indirectly activates the constitutive_active_androstane_receptor -LRB- CAR -RRB- by inhibition of epidermal_growth_factor_receptor signaling .
7646073	0	Phenobarbital	0,13	CYP2B1	27,33	Phenobarbital	CYP2B1	MESH:D010634	24300(Tax:10116)	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Phenobarbital induction of CYP2B1 , CYP2B2 , and CYP3A1 in rat liver : genetic differences in a common regulatory mechanism .
8643092	0	Phenobarbital	0,13	CYP2B1	35,41	Phenobarbital	CYP2B1	MESH:D010634	24300(Tax:10116)	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Phenobarbital induction of hepatic CYP2B1 and CYP2B2 : pretranscriptional and post-transcriptional effects of gender , adult age , and phenobarbital dose .
21455306	0	Phenobarbital	0,13	Cyp2b10	102,109	Phenobarbital	Cyp2b10	MESH:D010634	13088(Tax:10090)	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Phenobarbital mediates an epigenetic switch at the constitutive_androstane_receptor -LRB- CAR -RRB- target gene Cyp2b10 in the liver of B6C3F1 mice .
26400395	0	Phenobarbital	8,21	Cytochrome_P450	109,124	Phenobarbital	Cytochrome P450	MESH:D010634	13079(Tax:10090)	Chemical	Gene	Dose|nmod|START_ENTITY Factors|nsubj|Dose Factors|nmod|Induction Induction|nmod|Enzymes Enzymes|compound|END_ENTITY	Dose of Phenobarbital and Age of Treatment at Early Life are Two Key Factors for the Persistent Induction of Cytochrome_P450 Enzymes in Adult Mouse Liver .
3257910	0	Phenobarbital	0,13	EGF	22,25	Phenobarbital	EGF	MESH:D010634	25313(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|receptors receptors|compound|END_ENTITY	Phenobarbital reduces EGF receptors and the ability of physiological concentrations of calcium to suppress hepatocyte proliferation .
26980803	0	Phenobarbital	26,39	UDP-Glucuronosyltransferase_1a6	57,88	Phenobarbital	UDP-Glucuronosyltransferase 1a6	MESH:D010634	113992(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|Expression Expression|nmod|END_ENTITY	Correction to `` Effects of Phenobarbital on Expression of UDP-Glucuronosyltransferase_1a6 and 1a7 in Rat Brain '' .
3811968	0	Phenobarbital	0,13	aldehyde_dehydrogenase	27,49	Phenobarbital	aldehyde dehydrogenase	MESH:D010634	25375(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|amod|END_ENTITY	Phenobarbital enhances the aldehyde_dehydrogenase activity of rat hepatocytes in vitro and in vivo .
3919279	0	Phenobarbital	0,13	apolipoprotein_A-I	32,50	Phenobarbital	apolipoprotein A-I	MESH:D010634	25081(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|mRNA mRNA|compound|END_ENTITY	Phenobarbital induces rat liver apolipoprotein_A-I mRNA .
23652203	0	Phenobarbital	0,13	constitutive_active_androstane_receptor	39,78	Phenobarbital	constitutive active androstane receptor	MESH:D010634	9970	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Phenobarbital indirectly activates the constitutive_active_androstane_receptor -LRB- CAR -RRB- by inhibition of epidermal_growth_factor_receptor signaling .
6885729	0	Phenobarbital	0,13	cytochrome_P-450	107,123	Phenobarbital	cytochrome P-450	MESH:D010634	25251(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY synthesis|amod|END_ENTITY	Phenobarbital - and 3-methylcholanthrene-induced synthesis of two different molecular species of microsomal cytochrome_P-450 in rat liver .
3384091	0	Phenobarbital	0,13	cytochrome_P450	63,78	Phenobarbital	cytochrome P450	MESH:D010634	25251(Tax:10116)	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|mRNAs mRNAs|amod|END_ENTITY	Phenobarbital , dexamethasone and benzanthracene induce several cytochrome_P450 mRNAs in rat hepatoma cells .
8457190	0	Phenobarbital	0,13	glutathione_S-transferase	72,97	Phenobarbital	glutathione S-transferase	MESH:D010634	54486(Tax:10090)	Chemical	Gene	induction|amod|START_ENTITY mediates|nsubj|induction mediates|dobj|activation activation|nmod|expression expression|amod|END_ENTITY	Phenobarbital induction of AP-1 binding activity mediates activation of glutathione_S-transferase and quinone_reductase gene expression .
9673412	0	Phenobarbital	0,13	tumor_necrosis_factor	49,70	Phenobarbital	tumor necrosis factor	MESH:D010634	103694380	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|dobj|effects effects|nmod|END_ENTITY	Phenobarbital prevents the inhibitory effects of tumor_necrosis_factor on glutathione-S-transferase mu in primary culture rat hepatocytes .
12124314	0	Phenol	0,6	ST1A3	25,30	Phenol	ST1A3	MESH:D019800	6818	Chemical	Gene	sulfotransferase|amod|START_ENTITY sulfotransferase|appos|END_ENTITY	Phenol sulfotransferase , ST1A3 , as the main enzyme catalyzing sulfation of troglitazone in human liver .
10959796	0	Phenol	0,6	SULT1A1	25,32	Phenol	SULT1A1	MESH:D019800	6817	Chemical	Gene	polymorphism|amod|START_ENTITY polymorphism|compound|END_ENTITY	Phenol sulphotransferase SULT1A1 polymorphism in prostate_cancer : lack of association .
11692076	0	Phenol	0,6	SULT1A1	25,32	Phenol	SULT1A1	MESH:D019800	6817	Chemical	Gene	sulphotransferase|nsubj|START_ENTITY sulphotransferase|xcomp|END_ENTITY	Phenol sulphotransferase SULT1A1 * 1 genotype is associated with reduced risk of colorectal_cancer .
18006944	0	Phenol	0,6	SULT1A1	24,31	Phenol	SULT1A1	MESH:D019800	6817	Chemical	Gene	sulfotransferase|amod|START_ENTITY END_ENTITY|nsubj|sulfotransferase	Phenol sulfotransferase SULT1A1 * 2 allele and enhanced risk of upper urinary tract urothelial cell carcinoma .
9345314	0	Phenol	0,6	SULT1A1	74,81	Phenol	SULT1A1	MESH:D019800	6817	Chemical	Gene	pharmacogenetics|amod|START_ENTITY pharmacogenetics|dep|association association|nmod|alleles alleles|compound|END_ENTITY	Phenol sulfotransferase pharmacogenetics in humans : association of common SULT1A1 alleles with TS_PST phenotype .
9854023	0	Phenol	0,6	SULT1A1	25,32	Phenol	SULT1A1	MESH:D019800	6817	Chemical	Gene	polymorphism|amod|START_ENTITY polymorphism|compound|END_ENTITY	Phenol sulphotransferase SULT1A1 polymorphism : molecular diagnosis and allele frequencies in Caucasian and African populations .
26446794	0	Phenolic_Isoprenoid	15,34	Nrf2	109,113	Phenolic Isoprenoid	Nrf2	null	4780	Chemical	Gene	START_ENTITY|nmod|Activation Activation|compound|END_ENTITY	Bakuchiol is a Phenolic_Isoprenoid with Novel Enantiomer-Selective Anti-Influenza A Virus Activity Involving Nrf2 Activation .
14643306	0	Phenolics	0,9	PPAR-gamma	15,25	Phenolics	PPAR-gamma	null	19016(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Phenolics with PPAR-gamma ligand-binding activity obtained from licorice -LRB- Glycyrrhiza uralensis roots -RRB- and ameliorative effects of glycyrin on genetically diabetic KK-A -LRB- y -RRB- mice .
25197313	0	Phenols	23,30	CPT-1	97,102	Phenols	CPT-1	MESH:D010636	12895(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|Expression Expression|compound|END_ENTITY	Ananas comosus L. Leaf Phenols and p-Coumaric_Acid Regulate Liver Fat Metabolism by Upregulating CPT-1 Expression .
21414782	0	Phenoxyacetic_acids	0,19	PPAR	23,27	Phenoxyacetic acids	PPAR	null	5465	Chemical	Gene	START_ENTITY|nmod|agonists agonists|amod|END_ENTITY	Phenoxyacetic_acids as PPAR partial agonists : synthesis , optimization , and in vivo efficacy .
9592071	0	Phenserine	0,10	acetylcholinesterase	20,40	Phenserine	acetylcholinesterase	MESH:C092280	83817(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Phenserine , a novel acetylcholinesterase inhibitor , attenuates impaired learning of rats in a 14-unit T-maze induced by blockade of the N-methyl-D-aspartate receptor .
219013	0	Phentolamine	0,12	somatostatin	31,43	Phentolamine	somatostatin	MESH:D010646	6750	Chemical	Gene	action|amod|START_ENTITY action|nmod|END_ENTITY	Phentolamine and the action of somatostatin in man .
10937709	0	Phenylacetamides	0,16	alpha-1A_adrenergic_receptor	30,58	Phenylacetamides	alpha-1A adrenergic receptor	null	146	Chemical	Gene	START_ENTITY|nmod|antagonists antagonists|amod|END_ENTITY	Phenylacetamides as selective alpha-1A_adrenergic_receptor antagonists .
12657263	0	Phenylacetic_acid	0,17	hPPAR	33,38	Phenylacetic acid	hPPAR	MESH:C025136	5465	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Phenylacetic_acid derivatives as hPPAR agonists .
26352190	0	Phenylalanine	15,28	Aminopeptidase_B	86,102	Phenylalanine	Aminopeptidase B	CHEBI:28044	6051	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of Phenylalanine 297 in the Construction of the Substrate Pocket of Human Aminopeptidase_B .
22926069	0	Phenylalanine	0,13	GPR142	29,35	Phenylalanine	GPR142	CHEBI:28044	217302(Tax:10090)	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Phenylalanine derivatives as GPR142 agonists for the treatment of type_II_diabetes .
20887755	0	Phenylalanine	0,13	PAH	27,30	Phenylalanine	PAH	CHEBI:28044	18478(Tax:10090)	Chemical	Gene	hydroxylase|amod|START_ENTITY hydroxylase|appos|END_ENTITY	Phenylalanine hydroxylase -LRB- PAH -RRB- from the lower eukaryote Leishmania_major .
26823465	0	Phenylalanine	42,55	Phenylalanine_Hydroxylase	63,88	Phenylalanine	Phenylalanine Hydroxylase	CHEBI:28044	24616(Tax:10116)	Chemical	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of the Allosteric Site for Phenylalanine in Rat Phenylalanine_Hydroxylase .
6033458	0	Phenylalanine	0,13	tyrosine_hydroxylase	44,64	Phenylalanine	tyrosine hydroxylase	CHEBI:28044	7054	Chemical	Gene	START_ENTITY|nmod|substrate substrate|nmod|END_ENTITY	Phenylalanine as substrate and inhibitor of tyrosine_hydroxylase .
10515888	0	Phenylarsine_oxide	0,18	NF-kappaB	99,108	Phenylarsine oxide	NF-kappaB	MESH:C029341	4790	Chemical	Gene	blocks|nsubj|START_ENTITY blocks|dobj|activation activation|nmod|END_ENTITY	Phenylarsine_oxide blocks interleukin-1beta-induced activation of the nuclear transcription factor NF-kappaB , inhibits proliferation , and induces apoptosis of acute_myelogenous_leukemia cells .
7628642	0	Phenylarsine_oxide	0,18	phospholipase_C_gamma_2	56,79	Phenylarsine oxide	phospholipase C gamma 2	MESH:C029341	5336	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Phenylarsine_oxide inhibits tyrosine phosphorylation of phospholipase_C_gamma_2 in human platelets and phospholipase_C_gamma_1 in NIH-3T3 fibroblasts .
21268025	0	Phenylboronic_acid	0,18	insulin	82,89	Phenylboronic acid	insulin	MESH:C010686	3630	Chemical	Gene	grafted|compound|START_ENTITY chitosan|nsubj|grafted chitosan|nmod|vehicle vehicle|nmod|release release|compound|END_ENTITY	Phenylboronic_acid grafted chitosan as a glucose-sensitive vehicle for controlled insulin release .
26765145	0	Phenylboronic_acid	0,18	insulin	63,70	Phenylboronic acid	insulin	MESH:C010686	3630	Chemical	Gene	START_ENTITY|nsubj|release release|compound|END_ENTITY	Phenylboronic_acid as a glucose-responsive trigger to tune the insulin release of glycopolymer nanoparticles .
14560316	0	Phenylbutyrate	0,14	SMN	25,28	Phenylbutyrate	SMN	null	6606	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Phenylbutyrate increases SMN expression in vitro : relevance for treatment of spinal_muscular_atrophy .
12099715	0	Phenylephrine	0,13	Bad	42,45	Phenylephrine	Bad	MESH:D010656	64639(Tax:10116)	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Phenylephrine promotes phosphorylation of Bad in cardiac myocytes through the extracellular_signal-regulated_kinases_1 / 2 and protein_kinase_A .
15522277	0	Phenylephrine	0,13	CREB	36,40	Phenylephrine	CREB	MESH:D010656	81646(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|nmod|END_ENTITY	Phenylephrine induces activation of CREB in adult rat cardiac myocytes through MSK1 and PKA signaling pathways .
3818170	0	Phenylethylamide	0,16	gastrin	63,70	Phenylethylamide	gastrin	null	25320(Tax:10116)	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Phenylethylamide derivatives of the C-terminal tetrapeptide of gastrin .
19182394	0	Phenylethylamide	0,16	tyrosinase	58,68	Phenylethylamide	tyrosinase	null	7299	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Phenylethylamide and phenylmethylamide derivatives as new tyrosinase inhibitors .
15207360	0	Phenylethylidenehydrazine	0,25	GABA-transaminase	35,52	Phenylethylidenehydrazine	GABA-transaminase	MESH:C444559	81632(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Phenylethylidenehydrazine , a novel GABA-transaminase inhibitor , reduces epileptiform_activity in rat hippocampal slices .
2887428	0	Phenylglyoxal	0,13	D-amino-acid_oxidase	53,73	Phenylglyoxal	D-amino-acid oxidase	MESH:D010658	1610	Chemical	Gene	modification|amod|START_ENTITY modification|nmod|END_ENTITY	Phenylglyoxal modification of arginines in mammalian D-amino-acid_oxidase .
19470740	0	Phenylmethimazole	0,17	Toll-like_receptor_3	28,48	Phenylmethimazole	Toll-like receptor 3	MESH:C489637	7098	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|amod|END_ENTITY	Phenylmethimazole decreases Toll-like_receptor_3 and noncanonical Wnt5a expression in pancreatic_cancer and melanoma together with tumor cell growth and migration .
19470740	0	Phenylmethimazole	0,17	Wnt5a	66,71	Phenylmethimazole	Wnt5a	MESH:C489637	7474	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|amod|END_ENTITY	Phenylmethimazole decreases Toll-like_receptor_3 and noncanonical Wnt5a expression in pancreatic_cancer and melanoma together with tumor cell growth and migration .
8582037	0	Phenylphthalimides	0,18	tumor_necrosis_factor_alpha	24,51	Phenylphthalimides	tumor necrosis factor alpha	null	7124	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Phenylphthalimides with tumor_necrosis_factor_alpha production-enhancing activity .
22735309	0	Phenylpropanoid_glycosides	0,26	heme_oxygenase_1	59,75	Phenylpropanoid glycosides	heme oxygenase 1	null	3162	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|amod|END_ENTITY	Phenylpropanoid_glycosides from plant cell cultures induce heme_oxygenase_1 gene expression in a human keratinocyte cell line by affecting the balance of NRF2 and BACH1 transcription factors .
22477023	0	Phenylpyruvic_acid	0,18	glucose-6-phosphate_dehydrogenase	29,62	Phenylpyruvic acid	glucose-6-phosphate dehydrogenase	MESH:C031606	24377(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|activity activity|amod|END_ENTITY	Phenylpyruvic_acid decreases glucose-6-phosphate_dehydrogenase activity in rat brain .
16936065	0	Phenytoin	0,9	constitutive_androstane_receptor	59,91	Phenytoin	constitutive androstane receptor	MESH:D010672	12355(Tax:10090)	Chemical	Gene	induction|compound|START_ENTITY mediated|nsubjpass|induction mediated|nmod|END_ENTITY	Phenytoin induction of the cyp2c37 gene is mediated by the constitutive_androstane_receptor .
26370587	0	Phenytoin	0,9	epidermal_growth_factor_receptor	42,74	Phenytoin	epidermal growth factor receptor	MESH:D010672	13649(Tax:10090)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Phenytoin enhances the phosphorylation of epidermal_growth_factor_receptor and fibroblast growth factor receptor in the subventricular zone and promotes the proliferation of neural precursor cells and oligodendrocyte differentiation .
7583305	0	Phenytoin	0,9	microtubule-associated_protein_2	33,65	Phenytoin	microtubule-associated protein 2	MESH:D010672	4133	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Phenytoin inhibits expression of microtubule-associated_protein_2 and influences cell-viability and neurite growth of cultured cerebellar granule cells .
4853617	0	Phenytoin	0,9	parathyroid_hormone	24,43	Phenytoin	parathyroid hormone	MESH:D010672	5741	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	Phenytoin inhibition of parathyroid_hormone induced bone resorption in vitro .
512921	0	Phenytoin	0,9	renin	21,26	Phenytoin	renin	MESH:D010672	24715(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|compound|END_ENTITY	Phenytoin stimulates renin secretion from rat kidney slices .
14504193	0	Philippines	76,87	Androgen_receptor	0,17	Philippines	Androgen receptor	null	367	Chemical	Gene	polymorphism|nmod|START_ENTITY polymorphism|amod|END_ENTITY	Androgen_receptor gene polymorphism and breast_cancer susceptibility in The Philippines .
5295146	0	Philippines	33,44	Tor	22,25	Philippines	Tor	null	6097	Chemical	Gene	Studies|nmod|START_ENTITY Studies|nmod|END_ENTITY	Studies of cholera El Tor in the Philippines .
19723092	0	Phloretin	0,9	p53	95,98	Phloretin	p53	MESH:D010693	7157	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Phloretin induces apoptosis in H-Ras MCF10A human breast_tumor cells through the activation of p53 via JNK_and_p38 mitogen-activated protein kinase signaling .
26121582	0	Phlorizin	80,89	SGLT1	14,19	Phlorizin	SGLT1	MESH:D010695	6523	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of SGLT1 in Human Hearts and Impairment of Cardiac Glucose Uptake by Phlorizin during Ischemia-Reperfusion_Injury in Mice .
21963823	0	Phlorofucofuroeckol_A	0,21	iNOS	50,54	Phlorofucofuroeckol A	iNOS	MESH:C064093	18126(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Phlorofucofuroeckol_A inhibits the LPS-stimulated iNOS and COX-2 expressions in macrophages via inhibition of NF-kB , Akt , and p38_MAPK .
11904291	0	Phloxine_B	0,10	cystic_fibrosis_transmembrane_conductance_regulator	30,81	Phloxine B	cystic fibrosis transmembrane conductance regulator	MESH:D010697	1080	Chemical	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Phloxine_B interacts with the cystic_fibrosis_transmembrane_conductance_regulator at multiple sites to modulate channel activity .
2390085	0	Phorbol-12-myristate-13-acetate	0,31	phospholipase_D	46,61	Phorbol-12-myristate-13-acetate	phospholipase D	CHEBI:37537	2822	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Phorbol-12-myristate-13-acetate activation of phospholipase_D in human neutrophils leads to the production of phosphatides and diglycerides .
18975922	0	Phorbol-12-myristate_13-acetate	0,31	TSPO	109,113	Phorbol-12-myristate 13-acetate	TSPO	CHEBI:37537	12257(Tax:10090)	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|dobj|END_ENTITY	Phorbol-12-myristate_13-acetate acting through protein kinase Cepsilon_induces_translocator_protein _ -LRB- 18-kDa -RRB- TSPO gene expression .
1720402	0	Phorbol_12-myristate-13-acetate	0,31	cholecystokinin	78,93	Phorbol 12-myristate-13-acetate	cholecystokinin	CHEBI:37537	885	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|nmod|END_ENTITY	Phorbol_12-myristate-13-acetate -LRB- PMA -RRB- stimulates a differential expression of cholecystokinin -LRB- CCK -RRB- and c-fos mRNA in a human neuroblastoma cell line .
15567061	0	Phorbol_12-myristate_13-acetate	0,31	cyclooxygenase-2	44,60	Phorbol 12-myristate 13-acetate	cyclooxygenase-2	CHEBI:37537	5743	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Phorbol_12-myristate_13-acetate upregulates cyclooxygenase-2 expression in human pulmonary epithelial cells via Ras , Raf-1 , ERK , and NF-kappaB , but not p38 MAPK , pathways .
8600152	0	Phorbol_12-myristate_13-acetate	0,31	nm23	41,45	Phorbol 12-myristate 13-acetate	nm23	CHEBI:37537	4830	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Phorbol_12-myristate_13-acetate enhances nm23 gene expression in murine melanocytes but not in syngeneic B16-BL6 melanoma variants .
1709119	0	Phorbol_acetate	0,15	cytokeratins_8_and_18	48,69	Phorbol acetate	cytokeratins 8 and 18	null	3856;3875	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Phorbol_acetate enhances the phosphorylation of cytokeratins_8_and_18 in human colonic epithelial cells .
2499677	0	Phorbol_dibutyrate	0,18	endothelium-derived_relaxing_factor	50,85	Phorbol dibutyrate	endothelium-derived relaxing factor	null	51327	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|nmod|END_ENTITY	Phorbol_dibutyrate inhibits release and action of endothelium-derived_relaxing_factor -LRB- s -RRB- in canine blood vessels .
1283470	0	Phorbol_ester	0,13	CD4	41,44	Phorbol ester	CD4	CHEBI:37532	920	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|down-regulation down-regulation|nmod|expression expression|compound|END_ENTITY	Phorbol_ester induces down-regulation of CD4 molecule expression and resistance to in vitro infection by HIV1 .
12887687	0	Phorbol_ester	0,13	CYP2E1	22,28	Phorbol ester	CYP2E1	CHEBI:37532	1571	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Phorbol_ester induces CYP2E1 in astrocytes , through a protein kinase C - and tyrosine kinase-dependent mechanism .
8838143	0	Phorbol_ester	0,13	Fos	90,93	Phorbol ester	Fos	CHEBI:37532	314322(Tax:10116)	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|dep|role role|nmod|END_ENTITY	Phorbol_ester inhibition of rat gonadotropin-releasing hormone promoter activity : role of Fos and Jun in the repression of transcription .
9121495	0	Phorbol_ester	0,13	GnRH	64,68	Phorbol ester	GnRH	CHEBI:37532	14714(Tax:10090)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|gene gene|appos|END_ENTITY	Phorbol_ester regulation of the gonadotropin-releasing_hormone -LRB- GnRH -RRB- gene in GnRH-secreting cell lines : a molecular basis for species differences .
7931322	0	Phorbol_ester	0,13	MARCKS	86,92	Phorbol ester	MARCKS	CHEBI:37532	4082	Chemical	Gene	regulation|amod|START_ENTITY END_ENTITY|nsubj|regulation	Phorbol_ester - and retinoic_acid-induced regulation of the protein_kinase_C substrate MARCKS in immortalized hippocampal cells .
10523856	0	Phorbol_ester	0,13	MDR1	22,26	Phorbol ester	MDR1	CHEBI:37532	5243	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Phorbol_ester induced MDR1 expression in K562 cells occurs independently of mitogen-activated protein kinase signaling pathways .
22388989	0	Phorbol_ester	0,13	MUC5AC	49,55	Phorbol ester	MUC5AC	CHEBI:37532	4586	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Phorbol_ester or epidermal_growth-factor-induced MUC5AC mucin gene expression and production from airway epithelial cells are inhibited by apigenin and wogonin .
1464736	0	Phorbol_ester	0,13	NF_kappa_B	43,53	Phorbol ester	NF kappa B	CHEBI:37532	4790	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	Phorbol_ester reduces constitutive nuclear NF_kappa_B and inhibits HIV-1 production in mature human monocytic cells .
25137020	0	Phorbol_ester	0,13	PC3	98,101	Phorbol ester	PC3	CHEBI:37532	3853	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|END_ENTITY	Phorbol_ester stimulates ethanolamine release from the metastatic basal_prostate_cancer cell line PC3 but not from prostate epithelial cell lines LNCaP and P4E6 .
18077438	0	Phorbol_ester	0,13	RasGRP1	29,36	Phorbol ester	RasGRP1	CHEBI:37532	10125	Chemical	Gene	stimulation|amod|START_ENTITY stimulation|nmod|END_ENTITY	Phorbol_ester stimulation of RasGRP1 regulates the sodium-chloride cotransporter by a PKC-independent pathway .
2249989	0	Phorbol_ester	0,13	SP-A	42,46	Phorbol ester	SP-A	CHEBI:37532	653509	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Phorbol_ester inhibits surfactant protein SP-A and SP-B expression .
9780230	0	Phorbol_ester	0,13	androgen_receptor	58,75	Phorbol ester	androgen receptor	CHEBI:37532	367	Chemical	Gene	causes|nsubj|START_ENTITY causes|dobj|activation activation|nmod|END_ENTITY	Phorbol_ester causes ligand-independent activation of the androgen_receptor .
12433834	0	Phorbol_ester	0,13	angiotensin-converting_enzyme	27,56	Phorbol ester	angiotensin-converting enzyme	CHEBI:37532	11421(Tax:10090)	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|transcription transcription|amod|END_ENTITY	Phorbol_ester induction of angiotensin-converting_enzyme transcription is mediated by Egr-1 and AP-1 in human endothelial cells via ERK1/2 pathway .
1654122	0	Phorbol_ester	0,13	connexin_43	61,72	Phorbol ester	connexin 43	CHEBI:37532	2697	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Phorbol_ester induces phosphorylation and down-regulation of connexin_43 in WB cells .
9349535	0	Phorbol_ester	0,13	corticotrophin-releasing_factor_receptor_1	40,82	Phorbol ester	corticotrophin-releasing factor receptor 1	CHEBI:37532	12921(Tax:10090)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Phorbol_ester and calcium regulation of corticotrophin-releasing_factor_receptor_1 expression in a neuronal cell line .
18212352	0	Phorbol_ester	0,13	corticotropin-releasing_hormone	25,56	Phorbol ester	corticotropin-releasing hormone	CHEBI:37532	1392	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|amod|END_ENTITY	Phorbol_ester stimulates corticotropin-releasing_hormone gene promoter activity through a cAMP regulatory element in primary placental cells .
10924071	0	Phorbol_ester	0,13	cyclooxygenase-2	25,41	Phorbol ester	cyclooxygenase-2	CHEBI:37532	5743	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Phorbol_ester stimulates cyclooxygenase-2 expression and prostanoid production in cardiac_myocytes .
1317101	0	Phorbol_ester	0,13	erythropoietin	23,37	Phorbol ester	erythropoietin	CHEBI:37532	2056	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	Phorbol_ester inhibits erythropoietin production in human hepatoma cells -LRB- Hep G2 -RRB- .
7598724	0	Phorbol_ester	0,13	glia_maturation_factor	64,86	Phorbol ester	glia maturation factor	CHEBI:37532	2764	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Phorbol_ester stimulates rapid intracellular phosphorylation of glia_maturation_factor .
7579712	0	Phorbol_ester	0,13	heparin-binding_EGF-like_growth_factor	59,97	Phorbol ester	heparin-binding EGF-like growth factor	CHEBI:37532	1839	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|processing processing|nmod|END_ENTITY	Phorbol_ester induces the rapid processing of cell surface heparin-binding_EGF-like_growth_factor : conversion from juxtacrine to paracrine growth factor activity .
3263150	0	Phorbol_ester	0,13	interleukin-2	49,62	Phorbol ester	interleukin-2	CHEBI:37532	3558	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|receptors receptors|compound|END_ENTITY	Phorbol_ester induces expression and function of interleukin-2 receptors on a human leukemic cell line with a T-cell precursor phenotype .
2460462	0	Phorbol_ester	0,13	interleukin_6	24,37	Phorbol ester	interleukin 6	CHEBI:37532	24498(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	Phorbol_ester modulates interleukin_6 - and interleukin 1-regulated expression of acute phase plasma proteins in hepatoma cells .
1744113	0	Phorbol_ester	0,13	manganese-superoxide_dismutase	22,52	Phorbol ester	manganese-superoxide dismutase	CHEBI:37532	6648	Chemical	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Phorbol_ester induces manganese-superoxide_dismutase in tumor_necrosis_factor-resistant cells .
22388989	0	Phorbol_ester	0,13	mucin	56,61	Phorbol ester	mucin	CHEBI:37532	100508689	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Phorbol_ester or epidermal_growth-factor-induced MUC5AC mucin gene expression and production from airway epithelial cells are inhibited by apigenin and wogonin .
18084005	0	Phorbol_ester	0,13	phospholipase_D1	27,43	Phorbol ester	phospholipase D1	CHEBI:37532	18805(Tax:10090)	Chemical	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|END_ENTITY	Phorbol_ester up-regulates phospholipase_D1 but not phospholipase_D2 expression through a PKC/Ras/ERK / NFkappaB-dependent pathway and enhances matrix_metalloproteinase-9 secretion in colon_cancer cells .
2482208	0	Phorbol_ester	0,13	prolactin	25,34	Phorbol ester	prolactin	CHEBI:37532	5617	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|compound|END_ENTITY	Phorbol_ester stimulates prolactin release but reduces prolactin mRNA in the human B-lymphoblastoid cell line IM-9-P3 .
9593849	0	Phorbol_ester	0,13	protein_kinase_C-alpha	87,109	Phorbol ester	protein kinase C-alpha	CHEBI:37532	5578	Chemical	Gene	stimulation|amod|START_ENTITY requires|nsubj|stimulation requires|dobj|expression expression|nmod|END_ENTITY	Phorbol_ester stimulation of phosphatidylcholine synthesis requires expression of both protein_kinase_C-alpha and phospholipase_D .
2868000	0	Phorbol_ester	0,13	somatostatin	42,54	Phorbol ester	somatostatin	CHEBI:37532	24797(Tax:10116)	Chemical	Gene	modulates|compound|START_ENTITY END_ENTITY|nsubj|modulates	Phorbol_ester or diacylglycerol modulates somatostatin binding to its receptors on rat pancreatic acinar cell membranes .
2138160	0	Phorbol_ester	0,13	terminal_deoxynucleotidyl_transferase	28,65	Phorbol ester	terminal deoxynucleotidyl transferase	CHEBI:37532	1791	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Phorbol_ester regulation of terminal_deoxynucleotidyl_transferase , proliferation , and TcR_alpha in a pre-T cell line .
3102504	0	Phorbol_ester	0,13	urokinase-type_plasminogen_activator	129,165	Phorbol ester	urokinase-type plasminogen activator	CHEBI:37532	5328	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Phorbol_ester induces the biosynthesis of glycosylated and nonglycosylated plasminogen_activator_inhibitor_2 in high excess over urokinase-type_plasminogen_activator in human U-937 lymphoma cells .
11221888	0	Phorbol_esters	0,14	RasGRP3	48,55	Phorbol esters	RasGRP3	MESH:D010703	25780	Chemical	Gene	modulate|nsubj|START_ENTITY modulate|dobj|END_ENTITY	Phorbol_esters modulate the Ras exchange factor RasGRP3 .
3163923	0	Phorbol_esters	0,14	cholecystokinin	58,73	Phorbol esters	cholecystokinin	MESH:D010703	885	Chemical	Gene	stimulate|nsubj|START_ENTITY stimulate|dobj|release release|nmod|END_ENTITY	Phorbol_esters stimulate the potassium-induced release of cholecystokinin from slices of cerebral cortex , caudato-putamen and hippocampus incubated in vitro .
2862049	0	Phorbol_esters	0,14	growth_hormone	32,46	Phorbol esters	growth hormone	MESH:D010703	2688	Chemical	Gene	affect|nsubj|START_ENTITY affect|dobj|END_ENTITY	Phorbol_esters affect pituitary growth_hormone -LRB- GH -RRB- and prolactin release : the interaction with GH releasing factor , somatostatin and bromocriptine .
3264806	0	Phorbol_myristate_acetate	0,25	IL-2	34,38	Phorbol myristate acetate	IL-2	MESH:D013755	3558	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|secretion secretion|compound|END_ENTITY	Phorbol_myristate_acetate induces IL-2 secretion by HUT 78 cells by a mechanism independent of protein_kinase_C translocation .
11549266	0	Phorbol_myristate_acetate	0,25	X-linked_inhibitor_of_apoptosis	88,119	Phorbol myristate acetate	X-linked inhibitor of apoptosis	MESH:D013755	331	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|apoptosis apoptosis|nmod|END_ENTITY	Phorbol_myristate_acetate inhibits okadaic_acid-induced apoptosis and downregulation of X-linked_inhibitor_of_apoptosis in U937 cells .
3261032	0	Phorbol_myristate_acetate	0,25	interleukin-2	55,68	Phorbol myristate acetate	interleukin-2	MESH:D013755	3558	Chemical	Gene	reverses|nsubj|START_ENTITY reverses|dobj|inhibition inhibition|nmod|production production|compound|END_ENTITY	Phorbol_myristate_acetate -LRB- PMA -RRB- reverses inhibition of interleukin-2 production by T lymphocytes of patients with systemic_lupus_erythematosus .
25736046	1	Phosphate	45,54	Era	38,41	Phosphate	Era	CHEBI:26020	26284	Chemical	Gene	Therapy|compound|START_ENTITY END_ENTITY|nmod|Therapy	A New Era in Phosphate Binder Therapy in ESRD .
26551233	0	Phosphate	99,108	FGF23	63,68	Phosphate	FGF23	D010710	8074	Chemical	Gene	Levels|compound|START_ENTITY Administration|nmod|Levels Administration|nmod|Independently Independently|compound|END_ENTITY	Administration of Ferric_Citrate_Hydrate Decreases Circulating FGF23 Levels Independently of Serum Phosphate Levels in Hemodialysis Patients with Iron_Deficiency .
26792657	0	Phosphate	87,96	Fgf23	31,36	Phosphate	Fgf23	D010710	64654(Tax:10090)	Chemical	Gene	Challenge|compound|START_ENTITY Responses|nmod|Challenge Interruption|nmod|Responses Deletion|dep|Interruption Deletion|nmod|END_ENTITY	Conditional Deletion of Murine Fgf23 : Interruption of the Normal Skeletal Responses to Phosphate Challenge and Rescue of Genetic Hypophosphatemia .
9530108	0	Phosphate	0,9	NaPi-3	53,59	Phosphate	NaPi-3	CHEBI:26020	6569	Chemical	Gene	transport|amod|START_ENTITY transport|nmod|END_ENTITY	Phosphate transport by the human renal cotransporter NaPi-3 expressed in HEK-293 cells .
25057796	0	Phosphate	0,9	PTHrP	25,30	Phosphate	PTHrP	CHEBI:26020	19227(Tax:10090)	Chemical	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Phosphate interacts with PTHrP to regulate endochondral bone formation .
25556148	0	Phosphate	52,61	Parathyroid_Hormone	162,181	Phosphate	Parathyroid Hormone	CHEBI:26020	5741	Chemical	Gene	Binder|compound|START_ENTITY Change|nmod|Binder Restoration|nmod|Change Restoration|acl|Lanthanum_Carbonate Lanthanum_Carbonate|nmod|Patients Patients|nmod|END_ENTITY	Restoration of Parathyroid Function After Change of Phosphate Binder From Calcium_Carbonate to Lanthanum_Carbonate in Hemodialysis Patients With Suppressed Serum Parathyroid_Hormone .
25266663	0	Phosphate	34,43	Pho89	44,49	Phosphate	Pho89	CHEBI:26020	852599(Tax:4932)	Chemical	Gene	Transporter|compound|START_ENTITY Transporter|compound|END_ENTITY	Coregulated Expression of the Na + / Phosphate Pho89 Transporter and Ena1 Na + - ATPase Allows Their Functional Coupling under High-pH Stress .
20664908	0	Phosphate	0,9	PiT-1	101,106	Phosphate	PiT-1	CHEBI:26020	5449	Chemical	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Phosphate and vascular_calcification : Emerging role of the sodium-dependent phosphate co-transporter PiT-1 .
25684711	0	Phosphate	0,9	PiT-1	105,110	Phosphate	PiT-1	CHEBI:26020	18736(Tax:10090)	Chemical	Gene	uptake-independent|amod|START_ENTITY uptake-independent|acl|signaling signaling|dobj|functions functions|nmod|transporter transporter|appos|END_ENTITY	Phosphate uptake-independent signaling functions of the type III sodium-dependent phosphate transporter , PiT-1 , in vascular smooth muscle cells .
16667413	0	Phosphate	73,82	Ribonuclease	30,42	Phosphate	Ribonuclease	CHEBI:26020	544193(Tax:4081)	Chemical	Gene	Starvation|compound|START_ENTITY Cells|nmod|Starvation Induction|nmod|Cells Induction|nmod|END_ENTITY	Induction of an Extracellular Ribonuclease in Cultured Tomato Cells upon Phosphate Starvation .
21419244	0	Phosphate	0,9	bone_morphogenetic_protein-2	20,48	Phosphate	bone morphogenetic protein-2	CHEBI:26020	650	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Phosphate increases bone_morphogenetic_protein-2 expression through cAMP-dependent protein kinase and ERK1/2 pathways in human dental pulp cells .
26573634	0	Phosphate	19,28	gcd	89,92	Phosphate	gcd	D010710	390226	Chemical	Gene	START_ENTITY|nmod|Gene Gene|compound|END_ENTITY	Effects of Soluble Phosphate on Phosphate-Solubilizing Characteristics and Expression of gcd Gene in Pseudomonas frederiksbergensis JW-SD2 .
1001010	0	Phosphate	0,9	glutaminase	24,35	Phosphate	glutaminase	CHEBI:26020	24398(Tax:10116)	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Phosphate activation of glutaminase in sonicated mitochondria of normal and acidotic rat kidneys .
17068135	0	Phosphate	0,9	matrix_Gla_protein	21,39	Phosphate	matrix Gla protein	CHEBI:26020	17313(Tax:10090)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	Phosphate stimulates matrix_Gla_protein expression in chondrocytes through the extracellular signal regulated kinase signaling pathway .
10890885	0	Phosphate	0,9	osteopontin	48,59	Phosphate	osteopontin	CHEBI:26020	6696	Chemical	Gene	signal|nsubj|START_ENTITY signal|nmod|induction induction|nmod|expression expression|amod|END_ENTITY	Phosphate is a specific signal for induction of osteopontin gene expression .
19131315	0	Phosphate	0,9	osteopontin	20,31	Phosphate	osteopontin	CHEBI:26020	6696	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|amod|END_ENTITY	Phosphate regulates osteopontin gene transcription .
598054	0	Phosphate	0,9	parathyroid_hormone	94,113	Phosphate	parathyroid hormone	CHEBI:26020	5741	Chemical	Gene	excretion|amod|START_ENTITY excretion|dep|evidence evidence|nmod|mechanism mechanism|amod|other other|advcl|circulating circulating|dobj|END_ENTITY	Phosphate excretion in chronic_renal_failure : evidence for a mechanism other than circulating parathyroid_hormone .
20427710	0	Phosphatidic_acid	0,17	ERK	60,63	Phosphatidic acid	ERK	MESH:D010712	5594	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Phosphatidic_acid mediates activation of mTORC1 through the ERK signaling pathway .
11439134	0	Phosphatidic_acid	0,17	MAPK	46,50	Phosphatidic acid	MAPK	MESH:D010712	100305373(Tax:3847)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Phosphatidic_acid activates a wound-activated MAPK in Glycine_max .
20554760	0	Phosphatidic_acid	0,17	PDE4	104,108	Phosphatidic acid	PDE4	MESH:D010712	5141	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|compound|END_ENTITY	Phosphatidic_acid induces ligand-independent epidermal_growth_factor_receptor endocytic traffic through PDE4 activation .
7673163	1	Phosphatidic_acid	120,137	PTP1C	178,183	Phosphatidic acid	PTP1C	MESH:D010712	5777	Chemical	Gene	activates|nsubj|START_ENTITY activates|nmod|END_ENTITY	Phosphatidic_acid activates receptor dephosphorylation by PTP1C .
8626548	1	Phosphatidic_acid	94,111	Raf-1	143,148	Phosphatidic acid	Raf-1	MESH:D010712	5894	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|translocation translocation|nmod|END_ENTITY	Phosphatidic_acid regulates the translocation of Raf-1 in 12-O-tetradecanoylphorbol-13-acetate-stimulated Madin-Darby canine kidney cells .
8452869	0	Phosphatidic_acid	0,17	cyclic_nucleotide_phosphodiesterase	52,87	Phosphatidic acid	cyclic nucleotide phosphodiesterase	MESH:D010712	50678(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Phosphatidic_acid stimulates the rolipram-sensitive cyclic_nucleotide_phosphodiesterase from rat thymocytes .
23504314	0	Phosphatidic_acid	0,17	glyceraldehyde-3-phosphate_dehydrogenase	37,77	Phosphatidic acid	glyceraldehyde-3-phosphate dehydrogenase	MESH:D010712	838199(Tax:3702)	Chemical	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Phosphatidic_acid binds to cytosolic glyceraldehyde-3-phosphate_dehydrogenase and promotes its cleavage in Arabidopsis .
8626603	0	Phosphatidic_acid	0,17	interleukin_2	37,50	Phosphatidic acid	interleukin 2	MESH:D010712	3558	Chemical	Gene	generation|amod|START_ENTITY generation|nmod|END_ENTITY	Phosphatidic_acid generation through interleukin_2 -LRB- IL-2 -RRB- - induced alpha-diacylglycerol kinase activation is an essential step in IL-2-mediated lymphocyte proliferation .
19264150	0	Phosphatidic_acid	0,17	mTOR	31,35	Phosphatidic acid	mTOR	MESH:D010712	21977(Tax:10090)	Chemical	Gene	START_ENTITY|acl|signaling signaling|xcomp|END_ENTITY	Phosphatidic_acid signaling to mTOR : signals for the survival of human cancer cells .
24959196	0	Phosphatidic_acid	0,17	mTOR	27,31	Phosphatidic acid	mTOR	MESH:D010712	21977(Tax:10090)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|signaling signaling|compound|END_ENTITY	Phosphatidic_acid enhances mTOR signaling and resistance exercise induced hypertrophy .
20427710	0	Phosphatidic_acid	0,17	mTORC1	41,47	Phosphatidic acid	mTORC1	MESH:D010712	382056(Tax:10090)	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|nmod|END_ENTITY	Phosphatidic_acid mediates activation of mTORC1 through the ERK signaling pathway .
1627158	0	Phosphatidic_acid	0,17	phospholipase_C	82,97	Phosphatidic acid	phospholipase C	MESH:D010712	100009319(Tax:9986)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|xcomp|END_ENTITY	Phosphatidic_acid with medium-length fatty acyl chains synergistically stimulates phospholipase_C with Ca2 + in rabbit platelets .
11587359	0	Phosphatidyl_inositol	0,21	BCR/ABL	35,42	Phosphatidyl inositol	BCR/ABL	MESH:D010716	110279;11350	Chemical	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Phosphatidyl_inositol signaling by BCR/ABL : opportunities for drug development .
8981360	0	Phosphatidylcholine	0,19	CSF-1	45,50	Phosphatidylcholine	CSF-1	MESH:D010713	12977(Tax:10090)	Chemical	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Phosphatidylcholine signaling in response to CSF-1 .
17174597	0	Phosphatidylcholine	0,19	Sec14p	47,53	Phosphatidylcholine	Sec14p	MESH:D010713	855103(Tax:4932)	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Phosphatidylcholine transfer activity of yeast Sec14p is not essential for its function in vivo .
8760385	0	Phosphatidylethanol	0,19	plasma-membrane_calcium_pump	35,63	Phosphatidylethanol	plasma-membrane calcium pump	MESH:C051521	491	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Phosphatidylethanol stimulates the plasma-membrane_calcium_pump from human erythrocytes .
15910851	0	Phosphatidylethanol	0,19	vascular_endothelial_growth_factor	63,97	Phosphatidylethanol	vascular endothelial growth factor	MESH:C051521	7422	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Phosphatidylethanol in high density lipoproteins increases the vascular_endothelial_growth_factor in smooth muscle cells .
19032580	0	Phosphatidylethanol	0,19	vascular_endothelial_growth_factor	48,82	Phosphatidylethanol	vascular endothelial growth factor	MESH:C051521	7422	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Phosphatidylethanol mediates its effects on the vascular_endothelial_growth_factor via HDL receptor in endothelial cells .
24700333	0	Phosphatidylinositol	4,24	Factor_VIII	98,109	Phosphatidylinositol	Factor VIII	MESH:D010716	14069(Tax:10090)	Chemical	Gene	Activity|compound|START_ENTITY Activity|nmod|END_ENTITY	Soy Phosphatidylinositol Containing Nanoparticle Prolongs Hemostatic Activity of B-Domain Deleted Factor_VIII in Hemophilia_A Mice .
9684872	0	Phosphatidylinositol	0,20	PITPalpha	39,48	Phosphatidylinositol	PITPalpha	MESH:D010716	616550(Tax:9913)	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Phosphatidylinositol transfer protein -LRB- PITPalpha -RRB- stimulates in vitro intra-Golgi transport .
16943418	0	Phosphatidylinositol	0,20	Sp1	78,81	Phosphatidylinositol	Sp1	MESH:D010716	6667	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Phosphatidylinositol 3-kinase/protein kinase Czeta-induced phosphorylation of Sp1 and p107 repressor release have a critical role in histone deacetylase inhibitor-mediated derepression -LSB- corrected -RSB- of transcription of the luteinizing_hormone_receptor gene .
16644687	0	Phosphatidylinositol	0,20	akt	54,57	Phosphatidylinositol	akt	MESH:D010716	24185(Tax:10116)	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Phosphatidylinositol 3-kinase-dependent activation of akt , an essential signal for hyperthermia-induced heat-shock_protein_72 , is attenuated in streptozotocin-induced diabetic heart .
11912249	0	Phosphatidylinositol	0,20	epidermal_growth_factor	55,78	Phosphatidylinositol	epidermal growth factor	MESH:D010716	25313(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY required|nsubjpass|activity required|nmod|END_ENTITY	Phosphatidylinositol 3-kinase activity is required for epidermal_growth_factor to suppress proteolysis .
8900131	0	Phosphatidylinositol	0,20	epidermal_growth_factor	64,87	Phosphatidylinositol	epidermal growth factor	MESH:D010716	1950	Chemical	Gene	mediates|amod|START_ENTITY mediates|dep|effect effect|nmod|END_ENTITY	Phosphatidylinositol 3-kinase mediates the inhibitory effect of epidermal_growth_factor on calcium-dependent chloride secretion .
17460069	0	Phosphatidylinositol	0,20	p21	63,66	Phosphatidylinositol	p21	MESH:D010716	1026	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Phosphatidylinositol 3-Akt-kinase-dependent phosphorylation of p21 -LRB- Waf1/Cip1 -RRB- as a novel mechanism of neuroprotection by glucocorticoids .
11157484	0	Phosphatidylinositol	0,20	phospholipase_Cgamma2	57,78	Phosphatidylinositol	phospholipase Cgamma2	MESH:D010716	234779(Tax:10090)	Chemical	Gene	translocation|amod|START_ENTITY translocation|nmod|END_ENTITY	Phosphatidylinositol 3-kinase-dependent translocation of phospholipase_Cgamma2 in mouse megakaryocytes is independent of Bruton_tyrosine_kinase translocation .
26320582	0	Phosphatidylinositol_3-Phosphate	36,68	Tollip	26,32	Phosphatidylinositol 3-Phosphate	Tollip	MESH:C055525	54472	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Tom1 Modulates Binding of Tollip to Phosphatidylinositol_3-Phosphate via a Coupled Folding and Binding Mechanism .
26601944	0	Phosphatidylinositol_4-Phosphate	94,126	Oxysterol-binding_Protein	0,25	Phosphatidylinositol 4-Phosphate	Oxysterol-binding Protein	MESH:C037178	100760367	Chemical	Gene	Activation|nmod|START_ENTITY Activation|compound|END_ENTITY	Oxysterol-binding_Protein Activation at Endoplasmic Reticulum-Golgi Contact Sites Reorganizes Phosphatidylinositol_4-Phosphate Pools .
25543136	0	Phosphatidylinositol_Acyl	21,46	P53	0,3	Phosphatidylinositol Acyl	P53	null	7157	Chemical	Gene	Composition|compound|START_ENTITY Composition|compound|END_ENTITY	P53 Mutations Change Phosphatidylinositol_Acyl Chain Composition .
9915844	0	Phosphatidylserine	0,18	CD36	38,42	Phosphatidylserine	CD36	null	948	Chemical	Gene	receptors|amod|START_ENTITY receptors|dep|role role|nmod|END_ENTITY	Phosphatidylserine receptors : role of CD36 in binding of anionic phospholipid vesicles to monocytic cells .
21209961	0	Phosphatidylserine	0,18	IKBKAP	29,35	Phosphatidylserine	IKBKAP	null	8518	Chemical	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	Phosphatidylserine increases IKBKAP levels in familial_dysautonomia cells .
23515154	0	Phosphatidylserine	0,18	IKBKAP	29,35	Phosphatidylserine	IKBKAP	null	230233(Tax:10090)	Chemical	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	Phosphatidylserine increases IKBKAP levels in a humanized knock-in IKBKAP mouse model .
8423880	0	Phosphatidylserine	0,18	tumor_necrosis_factor	44,65	Phosphatidylserine	tumor necrosis factor	null	21926(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Phosphatidylserine , a putative inhibitor of tumor_necrosis_factor , prevents autoimmune_demyelination .
24477671	0	Phospho-GlcNAc	0,14	MLC2	34,38	Phospho-GlcNAc	MLC2	null	363925(Tax:10116)	Chemical	Gene	modulation|amod|START_ENTITY modulation|nmod|END_ENTITY	Phospho-GlcNAc modulation of slow MLC2 during soleus atrophy through a multienzymatic and sarcomeric complex .
27064611	0	Phosphoeleganin	31,46	Protein_Tyrosine_Phosphatase_1B	50,81	Phosphoeleganin	Protein Tyrosine Phosphatase 1B	null	5770	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|amod|END_ENTITY	Structure and Configuration of Phosphoeleganin , a Protein_Tyrosine_Phosphatase_1B Inhibitor from the Mediterranean Ascidian Sidnyum elegans .
8136771	0	Phosphoinositide	0,16	endothelin-1	81,93	Phosphoinositide	endothelin-1	CHEBI:18179	24323(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|dep|effects effects|nmod|END_ENTITY	Phosphoinositide metabolism and aging in aorta from SHR and WKY rats : effects of endothelin-1 and noradrenaline .
11440136	0	Phosphopeptides	0,15	phosvitin	42,51	Phosphopeptides	phosvitin	MESH:D010748	1460	Chemical	Gene	START_ENTITY|acl|derived derived|nmod|END_ENTITY	Phosphopeptides derived from hen egg yolk phosvitin : effect of molecular size on the calcium-binding properties .
18023582	0	Phosphoramidate	0,15	prostate-specific_membrane_antigen	64,98	Phosphoramidate	prostate-specific membrane antigen	MESH:C011067	2346	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|inhibitors inhibitors|nmod|END_ENTITY	Phosphoramidate derivatives of hydroxysteroids as inhibitors of prostate-specific_membrane_antigen .
1527713	0	Phosphoramidon	0,14	endothelin-1	42,54	Phosphoramidon	endothelin-1	MESH:C008890	100726197	Chemical	Gene	abolishes|nsubj|START_ENTITY abolishes|nmod|release release|amod|END_ENTITY	Phosphoramidon abolishes the increases in endothelin-1 release induced by ischemia-hypoxia in isolated perfused guinea_pig lungs .
1943466	0	Phosphoramidon	0,14	endothelin-1	66,78	Phosphoramidon	endothelin-1	MESH:C008890	24323(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|effects effects|acl|evoked evoked|nmod|END_ENTITY	Phosphoramidon inhibits the vasoconstrictor effects evoked by big endothelin-1 but not the elevation of plasma endothelin-1 in vivo .
2206130	0	Phosphoramidon	0,14	endothelin-1	140,152	Phosphoramidon	endothelin-1	MESH:C008890	1906	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|advcl|inhibiting inhibiting|dobj|enzyme enzyme|amod|END_ENTITY	Phosphoramidon , a metalloproteinase inhibitor , suppresses the secretion of endothelin-1 from cultured endothelial cells by inhibiting a big endothelin-1 converting enzyme .
2206130	0	Phosphoramidon	0,14	endothelin-1	75,87	Phosphoramidon	endothelin-1	MESH:C008890	1906	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|secretion secretion|nmod|cells cells|amod|END_ENTITY	Phosphoramidon , a metalloproteinase inhibitor , suppresses the secretion of endothelin-1 from cultured endothelial cells by inhibiting a big endothelin-1 converting enzyme .
8082712	0	Phosphoramidon	0,14	endothelin-1	43,55	Phosphoramidon	endothelin-1	MESH:C008890	24323(Tax:10116)	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|release release|amod|END_ENTITY	Phosphoramidon does not inhibit endogenous endothelin-1 release stimulated by hemorrhage , cytokines and hypoxia in rats .
25224571	0	Phosphorothioate	0,16	TLR9	37,41	Phosphorothioate	TLR9	null	54106	Chemical	Gene	modification|amod|START_ENTITY modification|nmod|END_ENTITY	Phosphorothioate modification of the TLR9 ligand CpG ODN inhibits poly -LRB- I : C -RRB- - induced apoptosis of hepatocellular_carcinoma by entry blockade .
12371973	0	Phosphorus	0,10	osteopontin	40,51	Phosphorus	osteopontin	MESH:D010758	6696	Chemical	Gene	up-regulate|nsubj|START_ENTITY up-regulate|dobj|expression expression|compound|END_ENTITY	Phosphorus and uremic serum up-regulate osteopontin expression in vascular smooth muscle cells .
10433700	0	Phosphoryl_oxime	0,16	acetylcholinesterase	31,51	Phosphoryl oxime	acetylcholinesterase	null	43	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Phosphoryl_oxime inhibition of acetylcholinesterase during oxime reactivation is prevented by edrophonium .
8174763	0	Phosphorylcholine	0,17	intestinal_alkaline_phosphatase	50,81	Phosphorylcholine	intestinal alkaline phosphatase	MESH:D010767	248	Chemical	Gene	START_ENTITY|nmod|substrate substrate|nmod|END_ENTITY	Phosphorylcholine as a unique substrate for human intestinal_alkaline_phosphatase .
26804975	0	Phosphoserine	0,13	phosphatase	14,25	Phosphoserine	phosphatase	CHEBI:15811	5723	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Phosphoserine phosphatase activity is elevated and correlates negatively with plasma d-serine concentration in patients with schizophrenia .
12644574	0	Phosphotyrosine	0,15	Bcr/Abl	27,34	Phosphotyrosine	Bcr/Abl	CHEBI:74956	25;613	Chemical	Gene	mapping|amod|START_ENTITY mapping|nmod|END_ENTITY	Phosphotyrosine mapping in Bcr/Abl oncoprotein using phosphotyrosine-specific immonium ion scanning .
9234717	0	Phosphotyrosine	0,15	Cbl	152,155	Phosphotyrosine	Cbl	CHEBI:74956	12402(Tax:10090)	Chemical	Gene	upregulation|amod|START_ENTITY upregulation|amod|alpha alpha|dep|signaling signaling|advcl|transforming transforming|dobj|mutants mutants|nmod|END_ENTITY	Phosphotyrosine binding domain-dependent upregulation of the platelet-derived growth factor receptor alpha signaling cascade by transforming mutants of Cbl : implications for Cbl 's function and oncogenicity .
9234717	0	Phosphotyrosine	0,15	Cbl	174,177	Phosphotyrosine	Cbl	CHEBI:74956	12402(Tax:10090)	Chemical	Gene	upregulation|amod|START_ENTITY upregulation|dep|implications implications|nmod|function function|nmod:poss|END_ENTITY	Phosphotyrosine binding domain-dependent upregulation of the platelet-derived growth factor receptor alpha signaling cascade by transforming mutants of Cbl : implications for Cbl 's function and oncogenicity .
15248398	0	Phosphotyrosine	1,16	SHP-1	29,34	Phosphotyrosine	SHP-1	CHEBI:74956	5777	Chemical	Gene	phosphatase|nsubj|START_ENTITY phosphatase|dobj|-RSB- -RSB-|compound|END_ENTITY	-LSB- Phosphotyrosine phosphatase SHP-1 , somatostatin and prostate_cancer -RSB- .
9733788	0	Phosphotyrosine	0,15	SHP-1	74,79	Phosphotyrosine	SHP-1	CHEBI:74956	5777	Chemical	Gene	1173|compound|START_ENTITY mediates|nsubj|1173 mediates|dobj|binding binding|nmod|END_ENTITY	Phosphotyrosine 1173 mediates binding of the protein-tyrosine phosphatase SHP-1 to the epidermal_growth_factor_receptor and attenuation of receptor signaling .
20672017	0	Phosphotyrosine	2,17	Tyrosine_Kinase	55,70	Phosphotyrosine	Tyrosine Kinase	CHEBI:74956	7294	Chemical	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	A Phosphotyrosine Proteomic Screen Identifies Multiple Tyrosine_Kinase Signaling Pathways Aberrantly Activated in Malignant_Mesothelioma .
8529673	0	Phosphotyrosine	0,15	nerve-growth-factor_receptor	32,60	Phosphotyrosine	nerve-growth-factor receptor	CHEBI:74956	24596(Tax:10116)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Phosphotyrosine residues in the nerve-growth-factor_receptor -LRB- Trk-A -RRB- .
8691146	0	Phosphotyrosines	0,16	protein_tyrosine_phosphatase_1C	131,162	Phosphotyrosines	protein tyrosine phosphatase 1C	null	5777	Chemical	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	Phosphotyrosines in the killer cell inhibitory receptor motif of NKB1 are required for negative signaling and for association with protein_tyrosine_phosphatase_1C .
18332045	0	Phthalate	0,9	CYP3A4	23,29	Phthalate	CYP3A4	MESH:C032279	1576	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Phthalate induction of CYP3A4 is dependent on glucocorticoid regulation of PXR expression .
16206033	0	Phthalide_Lactones	0,18	TNF-alpha	81,90	Phthalide Lactones	TNF-alpha	null	7124	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|production production|amod|END_ENTITY	Phthalide_Lactones from Ligusticum chuanxiong inhibit lipopolysaccharide-induced TNF-alpha production and TNF-alpha-mediated NF-kappaB Activation .
26805012	0	Phycocyanin	0,11	Nrf2	95,99	Phycocyanin	Nrf2	MESH:D010798	4780	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|nmod|END_ENTITY	Phycocyanin prevents methylglyoxal-induced mitochondrial-dependent apoptosis in INS-1 cells by Nrf2 .
19409496	0	Phyllomedusin	31,44	NK1_receptor	48,60	Phyllomedusin	NK1 receptor	MESH:C045322	6869	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Three-dimensional structure of Phyllomedusin , a NK1_receptor agonist bound to dodecylphosphocholine micelles .
9915808	0	Phytanic_acid	0,13	peroxisome_proliferator-activated_receptor_alpha	28,76	Phytanic acid	peroxisome proliferator-activated receptor alpha	MESH:D010831	19013(Tax:10090)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Phytanic_acid activates the peroxisome_proliferator-activated_receptor_alpha -LRB- PPARalpha -RRB- in sterol carrier protein 2 - / sterol_carrier_protein_x-deficient mice .
18204996	0	Phytoglycoprotein	0,17	interleukin-1beta	27,44	Phytoglycoprotein	interleukin-1beta	null	16176(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Phytoglycoprotein inhibits interleukin-1beta and interleukin-6 via p38 mitogen-activated protein kinase in lipopolysaccharide-stimulated RAW 264.7 cells .
16202384	0	Phytol	0,6	peroxisome_proliferator-activated_receptor_alpha	26,74	Phytol	peroxisome proliferator-activated receptor alpha	MESH:D010836	5465	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Phytol directly activates peroxisome_proliferator-activated_receptor_alpha -LRB- PPARalpha -RRB- and regulates gene expression involved in lipid metabolism in PPARalpha-expressing HepG2 hepatocytes .
17143496	0	Phytosphingosine	0,16	TRAIL	37,42	Phytosphingosine	TRAIL	MESH:C012491	8743	Chemical	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	Phytosphingosine in combination with TRAIL sensitizes cancer cells to TRAIL through synergistic up-regulation of DR4 and DR5 .
17143496	0	Phytosphingosine	0,16	TRAIL	70,75	Phytosphingosine	TRAIL	MESH:C012491	8743	Chemical	Gene	sensitizes|nsubj|START_ENTITY sensitizes|xcomp|END_ENTITY	Phytosphingosine in combination with TRAIL sensitizes cancer cells to TRAIL through synergistic up-regulation of DR4 and DR5 .
16763222	4	Pi	555,557	Akt	568,571	Pi	MEK	null	5609	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Pi activates Akt phosphorylation on Thr308 specifically , and activated signal transmits on the Raf/MEK/ERK signaling .
6400989	2	Pi	60,62	Alpha_1-antitrypsin	39,58	Pi	Alpha 1-antitrypsin	null	5265	Chemical	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Alpha_1-antitrypsin -LRB- Pi -RRB- polymorphism : report of a new allele -LRB- Pi S Berber -RRB- .
9639577	0	Pi	19,21	NaPi-2	64,70	Pi	NaPi-2	null	25548(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|dep|END_ENTITY	Effects of dietary Pi on the renal Na + - dependent Pi transporter NaPi-2 in thyroparathyroidectomized rats .
11704500	0	Pi	36,38	Npt2	54,58	Pi	Npt2	null	20505(Tax:10090)	Chemical	Gene	cotransporter|compound|START_ENTITY cotransporter|appos|END_ENTITY	Identification of the type II Na -LRB- + -RRB- - Pi cotransporter -LRB- Npt2 -RRB- in the osteoclast and the skeletal phenotype of Npt2 - / - mice .
17438129	0	Pi	22,24	Pit1	40,44	Pi	Pit1	null	25517(Tax:10116)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Osteoblast autonomous Pi regulation via Pit1 plays a role in bone mineralization .
16246727	0	Pi	0,2	eIF2	16,20	Pi	eIF2	null	1965	Chemical	Gene	release|compound|START_ENTITY release|nmod|END_ENTITY	Pi release from eIF2 , not GTP hydrolysis , is the step controlled by start-site selection during eukaryotic translation initiation .
7459358	0	Pi	35,37	growth_hormone	51,65	Pi	growth hormone	null	403795(Tax:9615)	Chemical	Gene	Regulation|nmod|START_ENTITY transport|nsubj|Regulation transport|nmod|END_ENTITY	Regulation of canine renal vesicle Pi transport by growth_hormone and parathyroid_hormone .
2361480	0	Pi	60,62	insulin-like_growth_factor-1	22,50	Pi	insulin-like growth factor-1	null	24482(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|nmod|transport	Stimulatory effect of insulin-like_growth_factor-1 on renal Pi transport and plasma 1,25-dihydroxyvitamin _ D3 .
20399183	0	Pi	0,2	myosin	16,22	Pi	myosin	null	79784	Chemical	Gene	release|compound|START_ENTITY release|nmod|END_ENTITY	Pi release from myosin : a simulation analysis of possible pathways .
2536233	0	Pi	27,29	parathyroid_hormone	43,62	Pi	parathyroid hormone	null	24694(Tax:10116)	Chemical	Gene	Regulation|nmod|START_ENTITY transport|nsubj|Regulation transport|nmod|END_ENTITY	Regulation of Na-dependent Pi transport by parathyroid_hormone in osteoblast-like cells .
2268073	0	Pi1	94,97	Igh	116,119	Pi1	Igh	null	406179(Tax:9823)	Chemical	Gene	group|compound|START_ENTITY group|amod|END_ENTITY	Polymorphism of pig serum alpha-protease inhibitor-3 -LRB- PI3 -RRB- and assignment of the locus to the Pi1 , Po1A , Po1B , Pi2 , Igh linkage group .
17062432	0	Piascledine	0,11	VEGF	40,44	Piascledine	VEGF	MESH:C003884	7422	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|production production|nmod|END_ENTITY	Piascledine modulates the production of VEGF and TIMP-1 and reduces the invasiveness of rheumatoid_arthritis synoviocytes .
25374129	0	Piceatannol	0,11	COX-2	57,62	Piceatannol	COX-2	MESH:C041525	19225(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Piceatannol inhibits phorbol_ester-induced expression of COX-2 and iNOS in HR-1 hairless mouse skin by blocking the activation of NF-kB and AP-1 .
12444159	0	Piceatannol	0,11	NF-kappaB	33,42	Piceatannol	NF-kappaB	MESH:C041525	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|compound|END_ENTITY	Piceatannol inhibits TNF-induced NF-kappaB activation and NF-kappaB-mediated gene expression through suppression of IkappaBalpha kinase and p65 phosphorylation .
20155627	0	Piceatannol	0,11	NF-kappa_B	43,53	Piceatannol	NF-kappa B	MESH:C041525	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|compound|END_ENTITY	Piceatannol inhibits phorbol_ester-induced NF-kappa_B activation and COX-2 expression in cultured human mammary epithelial cells .
20558128	0	Piceatannol	0,11	Nrf2	115,119	Piceatannol	Nrf2	MESH:C041525	4780	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Piceatannol induces heme_oxygenase-1 expression in human mammary epithelial cells through activation of ARE-driven Nrf2 signaling .
25360511	0	Piceatannol	0,11	SIRT1	57,62	Piceatannol	SIRT1	MESH:C041525	23411	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|compound|END_ENTITY	Piceatannol and its metabolite , isorhapontigenin , induce SIRT1 expression in THP-1 human monocytic cell line .
21167276	0	Piceatannol	0,11	Sp1	83,86	Piceatannol	Sp1	MESH:C041525	6667	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Piceatannol enhances TRAIL-induced apoptosis in human leukemia THP-1 cells through Sp1 - and ERK-dependent DR5 up-regulation .
16243536	0	Piceatannol	0,11	heme_oxygenase-1	36,52	Piceatannol	heme oxygenase-1	MESH:C041525	3162	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Piceatannol upregulates endothelial heme_oxygenase-1 expression via novel protein kinase C and tyrosine kinase pathways .
20558128	0	Piceatannol	0,11	heme_oxygenase-1	20,36	Piceatannol	heme oxygenase-1	MESH:C041525	3162	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Piceatannol induces heme_oxygenase-1 expression in human mammary epithelial cells through activation of ARE-driven Nrf2 signaling .
15597398	0	Picolinic_acids	0,15	dopamine_beta-monooxygenase	33,60	Picolinic acids	dopamine beta-monooxygenase	MESH:D010848	280758(Tax:9913)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Picolinic_acids as inhibitors of dopamine_beta-monooxygenase : QSAR and putative binding site .
3726156	0	Picomole	0,8	platelet-activating_factor	18,44	Picomole	platelet-activating factor	null	300795(Tax:10116)	Chemical	Gene	doses|amod|START_ENTITY doses|nmod|END_ENTITY	Picomole doses of platelet-activating_factor predispose the gastric mucosa to damage by topical irritants .
10211759	0	Picrotoxin	0,10	Fos	46,49	Picrotoxin	Fos	MESH:D010852	2353	Chemical	Gene	-|compound|START_ENTITY -|appos|END_ENTITY	Picrotoxin - , kainic_acid - and seizure-induced Fos in brainstem , with special reference to catecholamine cell groups .
23212569	0	Pill	18,22	brain-derived_neurotrophic_factor	66,99	Pill	brain-derived neurotrophic factor	null	24225(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of Zuogui Pill -LRB- -RRB- and Yougui Pill -LRB- -RRB- on the expression of brain-derived_neurotrophic_factor and cyclic_adenosine_monophosphate / protein kinase A signaling transduction pathways of axonal regeneration in model rats with experimental_autoimmune_encephalomyelitis .
22051186	5	Pilocarpine	785,796	CYP2A6	828,834	Pilocarpine	CYP2E1	MESH:D010862	1571	Chemical	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Pilocarpine binds and inhibits the hepatic CYP2A6 and respiratory CYP2A13 enzymes much more efficiently than the hepatic CYP2E1 enzyme .
11229771	0	Pimarane	0,8	cyclooxygenase_2	9,25	Pimarane	cyclooxygenase 2	MESH:C433018	5743	Chemical	Gene	START_ENTITY|dobj|inhibitor inhibitor|amod|END_ENTITY	Pimarane cyclooxygenase_2 -LRB- COX-2 -RRB- inhibitor and its structure-activity relationship .
11065173	0	Pimobendan	0,10	NF-kappaB	59,68	Pimobendan	NF-kappaB	MESH:C041648	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	Pimobendan inhibits the activation of transcription factor NF-kappaB : a mechanism which explains its inhibition of cytokine production and inducible nitric_oxide synthase .
2988977	0	Pindolol	0,8	angiotensin-converting_enzyme	26,55	Pindolol	angiotensin-converting enzyme	MESH:D010869	24310(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|activity activity|amod|END_ENTITY	Pindolol decreases plasma angiotensin-converting_enzyme activity in young spontaneously hypertensive rats .
2006240	0	Pindolol	0,8	prolactin	19,28	Pindolol	prolactin	MESH:D010869	5617	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|responses responses|compound|END_ENTITY	Pindolol decreases prolactin and growth_hormone responses to intravenous L-tryptophan .
22311160	0	Pingyangmycin	0,13	EGFR	46,50	Pingyangmycin	EGFR	MESH:C025703	13649(Tax:10090)	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|nmod|END_ENTITY	Pingyangmycin downregulates the expression of EGFR and enhances the effects of cetuximab on esophageal_cancer cells and the xenograft in athymic mice .
23725831	0	Pinocembrin	0,11	soluble_epoxide_hydrolase	67,92	Pinocembrin	soluble epoxide hydrolase	MESH:C016063	65030(Tax:10116)	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|END_ENTITY	Pinocembrin protects rats against cerebral_ischemic_damage through soluble_epoxide_hydrolase and epoxyeicosatrienoic_acids .
25826281	0	Pinoresinol	11,22	DAF-16	56,62	Pinoresinol	DAF-16	MESH:C103298	172981(Tax:6239)	Chemical	Gene	Induces|nsubj|START_ENTITY Induces|dobj|Translocation Translocation|nmod|END_ENTITY	The Lignan Pinoresinol Induces Nuclear Translocation of DAF-16 in Caenorhabditis_elegans but has No Effect on Life Span .
23831466	0	Pinusolide	0,10	insulin	41,48	Pinusolide	insulin	MESH:C101973	3630	Chemical	Gene	improves|nsubj|START_ENTITY improves|dobj|resistance resistance|compound|END_ENTITY	Pinusolide improves high glucose-induced insulin resistance via activation of AMP-activated protein kinase .
25405601	0	Pioglitazone	75,87	Adiponectin	0,11	Pioglitazone	Adiponectin	MESH:C060836	9370	Chemical	Gene	Treatment|compound|START_ENTITY Response|nmod|Treatment Patients|amod|Response Associated|nmod|Patients Associated|nsubj|T/G T/G|compound|END_ENTITY	Adiponectin Gene Polymorphism rs2241766 T/G Is Associated with Response to Pioglitazone Treatment in Type 2 Diabetic Patients from Southern China .
25894680	0	Pioglitazone	24,36	CA1	56,59	Pioglitazone	CA1	MESH:C060836	759	Chemical	Gene	START_ENTITY|nmod|Region Region|compound|END_ENTITY	Differential Effects of Pioglitazone in the Hippocampal CA1 Region Following Transient Forebrain_Ischemia in Low - and High-Fat Diet-Fed Gerbils .
24727493	0	Pioglitazone	0,12	COX-2	44,49	Pioglitazone	COX-2	MESH:C060836	26198(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|compound|END_ENTITY	Pioglitazone reduces angiotensin_II-induced COX-2 expression through inhibition of ROS production and ET-1 transcription in vascular cells from spontaneously hypertensive rats .
26507929	0	Pioglitazone	0,12	CXCR7	24,29	Pioglitazone	CXCR7	MESH:C060836	57007	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Pioglitazone Suppresses CXCR7 Expression To Inhibit Human Macrophage Chemotaxis through Peroxisome_Proliferator-Activated_Receptor_y .
16447051	0	Pioglitazone	0,12	CYP2C8	109,115	Pioglitazone	CYP2C8	MESH:C060836	1558	Chemical	Gene	increase|nsubj|START_ENTITY increase|dobj|concentrations concentrations|nmod|END_ENTITY	Pioglitazone , an in vitro inhibitor of CYP2C8 and CYP3A4 , does not increase the plasma concentrations of the CYP2C8 and CYP3A4 substrate repaglinide .
16447051	0	Pioglitazone	0,12	CYP2C8	39,45	Pioglitazone	CYP2C8	MESH:C060836	1558	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Pioglitazone , an in vitro inhibitor of CYP2C8 and CYP3A4 , does not increase the plasma concentrations of the CYP2C8 and CYP3A4 substrate repaglinide .
16867170	0	Pioglitazone	0,12	CYP2C8	31,37	Pioglitazone	CYP2C8	MESH:C060836	1558	Chemical	Gene	metabolised|nsubjpass|START_ENTITY metabolised|nmod|END_ENTITY	Pioglitazone is metabolised by CYP2C8 and CYP3A4 in vitro : potential for interactions with CYP2C8 inhibitors .
16867170	0	Pioglitazone	0,12	CYP2C8	91,97	Pioglitazone	CYP2C8	MESH:C060836	1558	Chemical	Gene	metabolised|nsubjpass|START_ENTITY metabolised|nmod|inhibitors inhibitors|amod|vitro vitro|dep|potential potential|nmod|interactions interactions|nmod|END_ENTITY	Pioglitazone is metabolised by CYP2C8 and CYP3A4 in vitro : potential for interactions with CYP2C8 inhibitors .
22739963	0	Pioglitazone	29,41	Insulin	92,99	Pioglitazone	Insulin	MESH:C060836	3630	Chemical	Gene	Effects|nmod|START_ENTITY Comparison|nmod|Effects Comparison|acl:relcl|Given Given|nmod|Treatment Treatment|compound|END_ENTITY	Comparison of the Effects of Pioglitazone versus Placebo when Given in Addition to Standard Insulin Treatment in Patients with Type_2_Diabetes_Mellitus Requiring Hemodialysis : Results from the PIOren Study .
25458644	0	Pioglitazone	0,12	Insulin	119,126	Pioglitazone	Insulin	MESH:C060836	3630	Chemical	Gene	START_ENTITY|dep|Rationale Rationale|nmod|Intervention Intervention|compound|END_ENTITY	Pioglitazone for secondary prevention after ischemic_stroke and transient_ischemic_attack : Rationale and design of the Insulin Resistance Intervention after Stroke Trial .
25954816	0	Pioglitazone	0,12	Insulin	34,41	Pioglitazone	Insulin	MESH:C060836	704534(Tax:9544)	Chemical	Gene	Increases|compound|START_ENTITY Whole|nsubj|Increases Whole|dobj|Sensitivity Sensitivity|compound|END_ENTITY	Pioglitazone Increases Whole Body Insulin Sensitivity in Obese , Insulin-Resistant Rhesus_Monkeys .
12958047	0	Pioglitazone	0,12	LOX-1	22,27	Pioglitazone	LOX-1	MESH:C060836	4973	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Pioglitazone inhibits LOX-1 expression in human coronary artery endothelial cells by reducing intracellular superoxide radical generation .
15694931	0	Pioglitazone	0,12	MMP-1	22,27	Pioglitazone	MMP-1	MESH:C060836	4312	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Pioglitazone inhibits MMP-1 expression in vascular smooth muscle cells through a mitogen-activated protein kinase-independent mechanism .
25607338	0	Pioglitazone	26,38	Osteoprotegerin	62,77	Pioglitazone	Osteoprotegerin	MESH:C060836	4982	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	The Comparative Effect of Pioglitazone and Metformin on Serum Osteoprotegerin , Adiponectin and Intercellular Adhesion Molecule Concentrations in Patients with Newly Diagnosed Type 2 Diabetes : a Randomized Clinical Trial .
25607338	0	Pioglitazone	26,38	Osteoprotegerin	62,77	Pioglitazone	Osteoprotegerin	MESH:C060836	4982	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	The Comparative Effect of Pioglitazone and Metformin on Serum Osteoprotegerin , Adiponectin and Intercellular Adhesion Molecule Concentrations in Patients with Newly Diagnosed Type 2 Diabetes : a Randomized Clinical Trial .
11380325	0	Pioglitazone	0,12	PPAR-gamma	25,35	Pioglitazone	PPAR-gamma	MESH:C060836	25664(Tax:10116)	Chemical	Gene	START_ENTITY|appos|ligand ligand|amod|END_ENTITY	Pioglitazone , a specific PPAR-gamma ligand , inhibits aspirin-induced gastric_mucosal_injury in rats .
12688511	0	Pioglitazone	0,12	PPAR-gamma	16,26	Pioglitazone	PPAR-gamma	MESH:C060836	19016(Tax:10090)	Chemical	Gene	START_ENTITY|appos|ligand ligand|amod|END_ENTITY	Pioglitazone , a PPAR-gamma ligand , provides protection from dextran sulfate sodium-induced colitis in mice in association with inhibition of the NF-kappaB-cytokine cascade .
18327303	0	Pioglitazone	0,12	PPAR-gamma	16,26	Pioglitazone	PPAR-gamma	MESH:C060836	5468	Chemical	Gene	START_ENTITY|appos|ligand ligand|amod|END_ENTITY	Pioglitazone , a PPAR-gamma ligand , exerts cytostatic/cytotoxic effects against cancer cells , that do not result from inhibition of proteasome .
20566448	0	Pioglitazone	0,12	PPAR-gamma	16,26	Pioglitazone	PPAR-gamma	MESH:C060836	25664(Tax:10116)	Chemical	Gene	inhibited|advmod|START_ENTITY inhibited|nsubj|ligand ligand|amod|END_ENTITY	Pioglitazone , a PPAR-gamma ligand inhibited the nicotinamide-streptozotocin induced sperm abnormalities_in_type-2 diabetic Wistar_rats .
22873050	0	Pioglitazone	1,13	PPAR-gamma	31,41	Pioglitazone	PPAR-gamma	MESH:C060836	5468	Chemical	Gene	START_ENTITY|appos|activator activator|nmod|END_ENTITY	-LSB- Pioglitazone , an activator of PPAR-gamma , reduces the expression of kB nuclear factor and inhibits apoptosis in mononuclear cells of peripheral blood in vitro -RSB- .
15737646	0	Pioglitazone	0,12	PPARgamma	49,58	Pioglitazone	PPARgamma	MESH:C060836	25664(Tax:10116)	Chemical	Gene	reverses|nsubj|START_ENTITY reverses|dobj|down-regulation down-regulation|nmod|expression expression|compound|END_ENTITY	Pioglitazone reverses down-regulation of cardiac PPARgamma expression in Zucker_diabetic_fatty_rats .
15769458	0	Pioglitazone	0,12	PPARgamma	16,25	Pioglitazone	PPARgamma	MESH:C060836	25664(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Pioglitazone , a PPARgamma agonist , restores endothelial function in aorta of streptozotocin-induced diabetic rats .
16520894	0	Pioglitazone	0,12	PPARgamma	37,46	Pioglitazone	PPARgamma	MESH:C060836	5468	Chemical	Gene	START_ENTITY|appos|ligand ligand|nmod|END_ENTITY	Pioglitazone , a synthetic ligand for PPARgamma , induces apoptosis in RB-deficient human colorectal_cancer cells .
18490130	0	Pioglitazone	0,12	PPARgamma	16,25	Pioglitazone	PPARgamma	MESH:C060836	25664(Tax:10116)	Chemical	Gene	ligand|advmod|START_ENTITY ligand|nsubj|END_ENTITY	Pioglitazone , a PPARgamma ligand , suppresses NFkappaB activation through inhibition of IkappaB kinase activation in cerulein-treated AR42J cells .
19737384	0	Pioglitazone	0,12	PPARgamma	146,155	Pioglitazone	PPARgamma	MESH:C060836	19016(Tax:10090)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|mechanism mechanism|advmod|regardless regardless|nmod|stimulation stimulation|compound|END_ENTITY	Pioglitazone enhances collateral blood flow in ischemic hindlimb of diabetic mice through an Akt-dependent VEGF-mediated mechanism , regardless of PPARgamma stimulation .
26643070	0	Pioglitazone	0,12	PPARy	16,21	Pioglitazone	PPARy	MESH:C060836	5468	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Pioglitazone , a PPARy agonist , attenuates PDGF-induced vascular smooth muscle cell proliferation through AMPK-dependent and AMPK-independent inhibition of mTOR/p70S6K and ERK signaling .
26507929	0	Pioglitazone	0,12	Peroxisome_Proliferator-Activated_Receptor_y	88,132	Pioglitazone	Peroxisome Proliferator-Activated Receptor y	MESH:C060836	5468	Chemical	Gene	Expression|compound|START_ENTITY Chemotaxis|nsubj|Expression Chemotaxis|nmod|END_ENTITY	Pioglitazone Suppresses CXCR7 Expression To Inhibit Human Macrophage Chemotaxis through Peroxisome_Proliferator-Activated_Receptor_y .
21127991	0	Pioglitazone	0,12	TGFb	22,26	Pioglitazone	TGFb	MESH:C060836	7040	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Pioglitazone inhibits TGFb induced keratocyte transformation to myofibroblast and extracellular matrix production .
16492207	0	Pioglitazone	0,12	adiponectin	35,46	Pioglitazone	adiponectin	MESH:C060836	9370	Chemical	Gene	increases|nsubj|START_ENTITY increases|xcomp|circulating circulating|dobj|levels levels|compound|END_ENTITY	Pioglitazone increases circulating adiponectin levels and subsequently reduces TNF-alpha levels in Type 2 diabetic patients : a randomized study .
16803857	0	Pioglitazone	0,12	adiponectin	58,69	Pioglitazone	adiponectin	MESH:C060836	9370	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|secretion secretion|nmod|END_ENTITY	Pioglitazone increases secretion of high-molecular-weight adiponectin from adipocytes .
18580598	0	Pioglitazone	0,12	adiponectin	23,34	Pioglitazone	adiponectin	MESH:C060836	9370	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|compound|END_ENTITY	Pioglitazone increases adiponectin levels in nondiabetic patients with coronary_artery_disease .
18824177	0	Pioglitazone	0,12	adiponectin	32,43	Pioglitazone	adiponectin	MESH:C060836	9370	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|compound|END_ENTITY	Pioglitazone acutely stimulates adiponectin secretion from mouse and human adipocytes via activation of the phosphatidylinositol 3 ' - kinase .
19096190	0	Pioglitazone	0,12	adiponectin	104,115	Pioglitazone	adiponectin	MESH:C060836	9370	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|nmod|END_ENTITY	Pioglitazone reduces the necrotic-core component in coronary plaque in association with enhanced plasma adiponectin in patients with type_2_diabetes_mellitus .
20662773	0	Pioglitazone	0,12	adiponectin	51,62	Pioglitazone	adiponectin	MESH:C060836	9370	Chemical	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Pioglitazone in the treatment of NASH : the role of adiponectin .
24114819	0	Pioglitazone	0,12	angiotensin_converting_enzyme	33,62	Pioglitazone	angiotensin converting enzyme	MESH:C060836	24310(Tax:10116)	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Pioglitazone upregulates hepatic angiotensin_converting_enzyme 2 expression in rats with steatohepatitis .
24582928	0	Pioglitazone	0,12	angiotensin_converting_enzyme	65,94	Pioglitazone	angiotensin converting enzyme	MESH:C060836	24310(Tax:10116)	Chemical	Gene	provides|nsubj|START_ENTITY provides|dobj|protection protection|acl|END_ENTITY	Pioglitazone , a PPARy agonist , provides comparable protection to angiotensin_converting_enzyme inhibitor ramipril against adriamycin nephropathy in rat .
16901490	0	Pioglitazone	0,12	connective_tissue_growth_factor	22,53	Pioglitazone	connective tissue growth factor	MESH:C060836	14219(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Pioglitazone inhibits connective_tissue_growth_factor expression in advanced atherosclerotic_plaques in low-density_lipoprotein_receptor-deficient mice .
25317811	0	Pioglitazone	0,12	cytochrome_P450_2E1	58,77	Pioglitazone	cytochrome P450 2E1	MESH:C060836	1571	Chemical	Gene	effect|amod|START_ENTITY effect|nmod|END_ENTITY	Pioglitazone , quercetin and hydroxy_citric_acid effect on cytochrome_P450_2E1 -LRB- CYP2E1 -RRB- enzyme levels in experimentally induced non_alcoholic_steatohepatitis -LRB- NASH -RRB- .
17084385	0	Pioglitazone	0,12	insulin	50,57	Pioglitazone	insulin	MESH:C060836	3630	Chemical	Gene	influences|nsubj|START_ENTITY influences|dobj|secretion secretion|compound|END_ENTITY	Pioglitazone acutely influences glucose-sensitive insulin secretion in normal and diabetic human islets .
19919569	0	Pioglitazone	0,12	insulin	139,146	Pioglitazone	insulin	MESH:C060836	3630	Chemical	Gene	improves|nsubj|START_ENTITY improves|dobj|response response|acl|peginterferon peginterferon|nmod|resistance resistance|compound|END_ENTITY	Pioglitazone improves virological response to peginterferon alpha-2b / ribavirin combination therapy in hepatitis_C genotype 4 patients with insulin resistance .
20237169	0	Pioglitazone	0,12	insulin	37,44	Pioglitazone	insulin	MESH:C060836	3630	Chemical	Gene	use|nsubj|START_ENTITY use|nmod|END_ENTITY	Pioglitazone use in combination with insulin in the prospective pioglitazone clinical trial in macrovascular events study -LRB- PROactive19 -RRB- .
8288044	0	Pioglitazone	0,12	insulin	23,30	Pioglitazone	insulin	MESH:C060836	704534(Tax:9544)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|sensitivity sensitivity|compound|END_ENTITY	Pioglitazone increases insulin sensitivity , reduces blood glucose , insulin , and lipid levels , and lowers blood pressure , in obese , insulin-resistant rhesus_monkeys .
24890117	0	Pioglitazone	0,12	matrix_metalloproteinase-9	40,66	Pioglitazone	matrix metalloproteinase-9	MESH:C060836	4318	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Pioglitazone inhibits the expression of matrix_metalloproteinase-9 , a protein involved in diabetes-associated wound healing .
21741366	0	Pioglitazone	0,12	p16	67,70	Pioglitazone	p16	MESH:C060836	1029	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Pioglitazone promotes preadipocyte proliferation by downregulating p16 -LRB- Ink4a -RRB- .
12473562	0	Pioglitazone	0,12	peroxisome_proliferator-activated_receptor-gamma	16,64	Pioglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C060836	19016(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Pioglitazone , a peroxisome_proliferator-activated_receptor-gamma agonist , attenuates left ventricular remodeling and failure after experimental myocardial_infarction .
12871756	0	Pioglitazone	0,12	peroxisome_proliferator-activated_receptor-gamma	35,83	Pioglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C060836	25664(Tax:10116)	Chemical	Gene	START_ENTITY|appos|ligand ligand|nmod|END_ENTITY	Pioglitazone , a specific ligand of peroxisome_proliferator-activated_receptor-gamma , accelerates gastric ulcer_healing in rat .
14691289	0	Pioglitazone	0,12	peroxisome_proliferator-activated_receptor-gamma	16,64	Pioglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C060836	25664(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Pioglitazone , a peroxisome_proliferator-activated_receptor-gamma agonist , attenuates myocardial_ischemia / reperfusion injury in a rat model .
15734860	0	Pioglitazone	0,12	peroxisome_proliferator-activated_receptor-gamma	69,117	Pioglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C060836	25664(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Pioglitazone induces vascular smooth muscle cell apoptosis through a peroxisome_proliferator-activated_receptor-gamma , transforming_growth_factor-beta1 , and a Smad2-dependent mechanism .
16419161	0	Pioglitazone	0,12	peroxisome_proliferator-activated_receptor-gamma	35,83	Pioglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C060836	25664(Tax:10116)	Chemical	Gene	START_ENTITY|appos|ligand ligand|nmod|END_ENTITY	Pioglitazone , a specific ligand of peroxisome_proliferator-activated_receptor-gamma , protects pancreas against acute cerulein-induced_pancreatitis .
18272184	0	Pioglitazone	0,12	peroxisome_proliferator-activated_receptor-gamma	108,156	Pioglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C060836	19016(Tax:10090)	Chemical	Gene	START_ENTITY|dep|not not|nmod|pathway pathway|amod|END_ENTITY	Pioglitazone and dexamethasone induce adipogenesis in D1 bone marrow stromal cell line , but not through the peroxisome_proliferator-activated_receptor-gamma pathway .
18313605	0	Pioglitazone	0,12	peroxisome_proliferator-activated_receptor-gamma	16,64	Pioglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C060836	100008892(Tax:9986)	Chemical	Gene	START_ENTITY|appos|activator activator|amod|END_ENTITY	Pioglitazone , a peroxisome_proliferator-activated_receptor-gamma activator , attenuates atrial_fibrosis and atrial_fibrillation promotion in rabbits with congestive_heart_failure .
19189639	0	Pioglitazone	0,12	peroxisome_proliferator-activated_receptor-gamma	27,75	Pioglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C060836	5468	Chemical	Gene	acts|advmod|START_ENTITY acts|nsubj|ligand ligand|nmod|END_ENTITY	Pioglitazone , a ligand for peroxisome_proliferator-activated_receptor-gamma acts as an inhibitor of colon_cancer liver metastasis .
21757589	0	Pioglitazone	0,12	peroxisome_proliferator-activated_receptor-y	16,60	Pioglitazone	peroxisome proliferator-activated receptor-y	MESH:C060836	5468	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Pioglitazone , a peroxisome_proliferator-activated_receptor-y agonist , induces dilation of isolated porcine retinal arterioles : role of nitric_oxide and potassium channels .
12795455	0	Pioglitazone	0,12	peroxisome_proliferator-activated_receptor_gamma	39,87	Pioglitazone	peroxisome proliferator-activated receptor gamma	MESH:C060836	25664(Tax:10116)	Chemical	Gene	reduces|advmod|START_ENTITY reduces|nsubj|ligand ligand|nmod|END_ENTITY	Pioglitazone , a specific ligand of the peroxisome_proliferator-activated_receptor_gamma reduces gastric mucosal_injury induced by ischaemia / reperfusion in rat .
15692987	0	Pioglitazone	0,12	peroxisome_proliferator-activated_receptor_gamma	16,64	Pioglitazone	peroxisome proliferator-activated receptor gamma	MESH:C060836	100729138	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Pioglitazone , a peroxisome_proliferator-activated_receptor_gamma agonist , reduces the progression of experimental osteoarthritis in guinea_pigs .
15698832	0	Pioglitazone	0,12	peroxisome_proliferator-activated_receptor_gamma	16,64	Pioglitazone	peroxisome proliferator-activated receptor gamma	MESH:C060836	25664(Tax:10116)	Chemical	Gene	START_ENTITY|appos|activator activator|amod|END_ENTITY	Pioglitazone , a peroxisome_proliferator-activated_receptor_gamma activator , ameliorates experimental autoimmune_myocarditis by modulating Th1/Th2 balance .
25025992	0	Pioglitazone	0,12	peroxisome_proliferator-activated_receptor_y	16,60	Pioglitazone	peroxisome proliferator-activated receptor y	MESH:C060836	5468	Chemical	Gene	START_ENTITY|appos|activator activator|amod|END_ENTITY	Pioglitazone , a peroxisome_proliferator-activated_receptor_y activator , suppresses coronary_spasm .
26797396	0	Pioglitazone	0,12	phosphatidylethanolamine_N-methyltransferase	61,105	Pioglitazone	phosphatidylethanolamine N-methyltransferase	MESH:C060836	18618(Tax:10090)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|nmod|END_ENTITY	Pioglitazone attenuates hepatic_inflammation and fibrosis in phosphatidylethanolamine_N-methyltransferase - -LRB- PEMT -RRB- deficient mice .
25523934	0	Pioglitazone	0,12	receptor_for_advanced_glycation_end_products	57,101	Pioglitazone	receptor for advanced glycation end products	MESH:C060836	81722(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Pioglitazone inhibits high glucose-induced expression of receptor_for_advanced_glycation_end_products in coronary artery smooth muscle cells .
25634757	0	Pioglitazone	0,12	retinol_binding_protein_4	26,51	Pioglitazone	retinol binding protein 4	MESH:C060836	25703(Tax:10116)	Chemical	Gene	lowers|nsubj|START_ENTITY lowers|dobj|END_ENTITY	Pioglitazone lowers serum retinol_binding_protein_4 by suppressing its expression in adipose tissue of obese rats .
9288574	0	Pioglitazone	0,12	tumor_necrosis_factor-alpha	65,92	Pioglitazone	tumor necrosis factor-alpha	MESH:C060836	7124	Chemical	Gene	induced|nsubj|START_ENTITY induced|nmod|END_ENTITY	Pioglitazone and metformin reverse insulin resistance induced by tumor_necrosis_factor-alpha in liver cells .
18031315	0	Pioglitazone	0,12	visfatin	111,119	Pioglitazone	visfatin	MESH:C060836	10135	Chemical	Gene	added|nsubj|START_ENTITY added|nmod|women women|dep|increments increments|nmod|adiponectin adiponectin|amod|END_ENTITY	Pioglitazone -LRB- 7.5 mg/day -RRB- added to flutamide-metformin in women with androgen excess : additional increments of visfatin and high molecular weight adiponectin .
20347593	0	Piperazine_sulfonamide	0,22	BACE1	23,28	Piperazine sulfonamide	BACE1	null	23821(Tax:10090)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Piperazine_sulfonamide BACE1 inhibitors : design , synthesis , and in vivo characterization .
16279786	0	Piperazinobenzopyranones	0,24	breast_cancer_resistance_protein	80,112	Piperazinobenzopyranones	breast cancer resistance protein	null	9429	Chemical	Gene	START_ENTITY|dep|inhibitors inhibitors|nmod|END_ENTITY	Piperazinobenzopyranones and phenalkylaminobenzopyranones : potent inhibitors of breast_cancer_resistance_protein -LRB- ABCG2 -RRB- .
17383873	0	Piperazinyl	0,11	CCR1	12,16	Piperazinyl	CCR1	null	1230	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|compound|END_ENTITY	Piperazinyl CCR1 antagonists -- optimization of human liver microsome stability .
11347960	0	Piperidine	0,10	renin	11,16	Piperidine	renin	MESH:C032727	5972	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Piperidine renin inhibitors : from leads to drug candidates .
19285862	0	Piperidinyl-2-phenethylamino	0,28	DPP-IV	43,49	Piperidinyl-2-phenethylamino	DPP-IV	null	1803	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Piperidinyl-2-phenethylamino inhibitors of DPP-IV for the treatment of type 2 diabetes .
20580234	0	Piperidinyl-nicotinamides	0,25	somatostatin_receptor_subtype_5	50,81	Piperidinyl-nicotinamides	somatostatin receptor subtype 5	null	6755	Chemical	Gene	START_ENTITY|nmod|antagonists antagonists|amod|END_ENTITY	Piperidinyl-nicotinamides as potent and selective somatostatin_receptor_subtype_5 antagonists .
25471891	0	Piperine	0,8	CXCL8	38,43	Piperine	CXCL8	MESH:C008922	3576	Chemical	Gene	Suppresses|nsubj|START_ENTITY Suppresses|dobj|Expression Expression|nmod|END_ENTITY	Piperine Suppresses the Expression of CXCL8 in Lipopolysaccharide-Activated SW480 and HT-29 Cells via Downregulating the Mitogen-Activated Protein Kinase Pathways .
25234193	0	Piperine	0,8	IL-6	32,36	Piperine	IL-6	MESH:C008922	3569	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Piperine inhibits IL-1b-induced IL-6 expression by suppressing p38 MAPK and STAT3 activation in gastric_cancer cells .
26431033	0	Piperine	0,8	Low-Density_Lipoprotein_Receptor	25,57	Piperine	Low-Density Lipoprotein Receptor	MESH:C008922	3949	Chemical	Gene	START_ENTITY|dobj|Expression Expression|compound|END_ENTITY	Piperine Induces Hepatic Low-Density_Lipoprotein_Receptor Expression through Proteolytic Activation of Sterol Regulatory Element-Binding Proteins .
23911889	0	Piperine	0,8	TRPV1	45,50	Piperine	TRPV1	MESH:C008922	193034(Tax:10090)	Chemical	Gene	exerts|nsubj|START_ENTITY exerts|dobj|effects effects|nmod|receptor receptor|compound|END_ENTITY	Piperine exerts anti-seizure effects via the TRPV1 receptor in mice .
22542552	0	Piperine	0,8	cyclooxygenase-2	30,46	Piperine	cyclooxygenase-2	MESH:C008922	19225(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Piperine inhibits PMA-induced cyclooxygenase-2 expression through downregulating NF-kB , C/EBP and AP-1 signaling pathways in murine macrophages .
23707768	0	Piperine	0,8	pregnane_X_receptor	25,44	Piperine	pregnane X receptor	MESH:C008922	8856	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Piperine activates human pregnane_X_receptor to induce the expression of cytochrome_P450_3A4 and multidrug_resistance_protein_1 .
25023940	0	Piperlongumine	0,14	CHOP	55,59	Piperlongumine	CHOP	MESH:C498077	1649	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|compound|END_ENTITY	Piperlongumine induces cell death through ROS-mediated CHOP activation and potentiates TRAIL-induced cell death in breast_cancer cells .
26963494	0	Piperlongumine	0,14	TrxR1	27,32	Piperlongumine	TrxR1	MESH:C498077	7296	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|amod|END_ENTITY	Piperlongumine as a direct TrxR1 inhibitor with suppressive activity against gastric_cancer .
24879047	0	Piperlongumine	0,14	peroxiredoxin_4	37,52	Piperlongumine	peroxiredoxin 4	MESH:C498077	10549	Chemical	Gene	treatment|amod|START_ENTITY inactivates|nsubj|treatment inactivates|dobj|END_ENTITY	Piperlongumine treatment inactivates peroxiredoxin_4 , exacerbates endoplasmic_reticulum_stress , and preferentially kills high-grade glioma cells .
20739378	0	Piragliatin	0,11	glucokinase	33,44	Piragliatin	glucokinase	MESH:C553963	2645	Chemical	Gene	START_ENTITY|appos|activator activator|compound|END_ENTITY	Piragliatin -LRB- RO4389620 -RRB- , a novel glucokinase activator , lowers plasma glucose both in the postabsorptive state and after a glucose challenge in patients with type_2_diabetes_mellitus : a mechanistic study .
8005563	0	Pirenzepine	0,11	GH	43,45	Pirenzepine	GH	MESH:D010890	2688	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|secretion secretion|compound|END_ENTITY	Pirenzepine decreases basal and stimulated GH secretion in patients with type 2 -LRB- non-insulin-dependent -RRB- diabetes_mellitus .
3116574	0	Pirenzepine	0,11	growth_hormone	21,35	Pirenzepine	growth hormone	MESH:D010890	2688	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Pirenzepine inhibits growth_hormone , but not thyrotropin response to thyrotropin-releasing_hormone in patients with endogenous_depression .
23664858	0	Pirfenidone	0,11	COX-2	37,42	Pirfenidone	COX-2	MESH:C093844	4513	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|END_ENTITY	Pirfenidone attenuates IL-1b-induced COX-2 and PGE2 production in orbital fibroblasts through suppression of NF-kB activity .
15293605	0	Pirfenidone	0,11	HSP47	37,42	Pirfenidone	HSP47	MESH:C093844	12406(Tax:10090)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|nmod|END_ENTITY	Pirfenidone attenuates expression of HSP47 in murine bleomycin-induced pulmonary_fibrosis .
18093617	0	Pirfenidone	0,11	HSP47	39,44	Pirfenidone	HSP47	MESH:C093844	871	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Pirfenidone inhibits the expression of HSP47 in TGF-beta1-stimulated human lung fibroblasts .
17234158	0	Pirfenidone	0,11	TGF-beta	21,29	Pirfenidone	TGF-beta	MESH:C093844	7040	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Pirfenidone inhibits TGF-beta expression in malignant_glioma cells .
20053983	0	Pirfenidone	23,34	TIMP-1	123,129	Pirfenidone	TIMP-1	MESH:C093844	7076	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Antifibrotic effect of Pirfenidone on orbital fibroblasts of patients with thyroid-associated_ophthalmopathy by decreasing TIMP-1 and collagen levels .
12098599	0	Pirfenidone	0,11	tumor_necrosis_factor-alpha	23,50	Pirfenidone	tumor necrosis factor-alpha	MESH:C093844	21926(Tax:10090)	Chemical	Gene	suppresses|amod|START_ENTITY END_ENTITY|nsubj|suppresses	Pirfenidone suppresses tumor_necrosis_factor-alpha , enhances interleukin-10 and protects mice from endotoxic_shock .
9368911	0	Pirlindole	0,10	monoamine_oxidase_A	48,67	Pirlindole	monoamine oxidase A	MESH:C009830	29253(Tax:10116)	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	Pirlindole : a selective reversible inhibitor of monoamine_oxidase_A .
9617344	0	Piroxicam	0,9	APC	88,91	Piroxicam	APC	MESH:D010894	11789(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|compound|END_ENTITY	Piroxicam and acarbose as chemopreventive agents for spontaneous intestinal_adenomas in APC gene 1309 knockout mice .
24631063	0	Piroxicam	0,9	cyclooxygenase_2	37,53	Piroxicam	cyclooxygenase 2	MESH:D010894	5743	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Piroxicam inhibits Masitinib-induced cyclooxygenase_2 expression in oral_squamous_cell_carcinoma cells in vitro .
25459137	0	Piroxicam	50,59	matrix_metalloproteinase-2	14,40	Piroxicam	matrix metalloproteinase-2	MESH:D010894	17390(Tax:10090)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of matrix_metalloproteinase-2 and 9 by Piroxicam confer neuroprotection in cerebral_ischemia : An in silico evaluation of the hypothesis .
21521932	0	Pitavastatin	0,12	ABCA1	23,28	Pitavastatin	ABCA1	MESH:C108475	313210(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Pitavastatin increases ABCA1 expression by dual mechanisms : SREBP2-driven transcriptional activation and PPARa-dependent protein stabilization but without activating LXR in rat hepatoma McARH7777 cells .
26754586	0	Pitavastatin	10,22	ApoB-48	36,43	Pitavastatin	ApoB-48	MESH:C108475	338	Chemical	Gene	Treatment|compound|START_ENTITY Treatment|nmod|END_ENTITY	Effect of Pitavastatin Treatment on ApoB-48 and Lp-PLA in Patients with Metabolic_Syndrome : Sub-study of PROspective Comparative Clinical Study Evaluating the Efficacy and Safety of PITavastatin in Patients with Metabolic_Syndrome .
21028996	0	Pitavastatin	0,12	C-reactive_protein	52,70	Pitavastatin	C-reactive protein	MESH:C108475	1401	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|levels levels|amod|END_ENTITY	Pitavastatin further decreases serum high-sensitive C-reactive_protein levels in hypertensive patients with hypercholesterolemia treated with angiotensin_II , _ type-1_receptor antagonists .
20495513	0	Pitavastatin	0,12	HMG-CoA_reductase	25,42	Pitavastatin	HMG-CoA reductase	MESH:C108475	3156	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Pitavastatin : the newest HMG-CoA_reductase inhibitor .
20940516	0	Pitavastatin	0,12	IL-18	30,35	Pitavastatin	IL-18	MESH:C108475	3606	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|levels levels|compound|END_ENTITY	Pitavastatin reduces elevated IL-18 levels in Japanese subjects with hypercholesterolemia : sub-analysis of Kansai investigation of statin for hyperlipidemic intervention in metabolism and endocrinology -LRB- KISHIMEN -RRB- .
21162230	0	Pitavastatin	32,44	Klotho	52,58	Pitavastatin	Klotho	MESH:C108475	16591(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- The pro-angiogenesis effect of Pitavastatin in the Klotho gene-knockout mice -RSB- .
18572174	0	Pitavastatin	0,12	PON1	21,25	Pitavastatin	PON1	MESH:C108475	5444	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Pitavastatin induces PON1 expression through p44/42 mitogen-activated protein kinase signaling cascade in Huh7 cells .
15502389	0	Pitavastatin	0,12	cholesterol_7_alpha-hydroxylase	87,118	Pitavastatin	cholesterol 7 alpha-hydroxylase	MESH:C108475	1581	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Pitavastatin , a potent hydroxymethylglutaryl coenzyme a reductase inhibitor , increases cholesterol_7_alpha-hydroxylase gene expression in HepG2 cells .
20045866	0	Pitavastatin	0,12	endothelial_lipase	41,59	Pitavastatin	endothelial lipase	MESH:C108475	9388	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|nmod|END_ENTITY	Pitavastatin decreases the expression of endothelial_lipase both in vitro and in vivo .
12235080	0	Pk11195	0,7	mitochondrial_benzodiazepine_receptor	11,48	Pk11195	mitochondrial benzodiazepine receptor	MESH:C037850	706	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Pk11195 , a mitochondrial_benzodiazepine_receptor antagonist , reduces apoptosis threshold in Bcl-X -LRB- L -RRB- and Mcl-1 expressing human cholangiocarcinoma cells .
25198697	7	Pla	1247,1250	OMV	1255,1258	Pla	Pla	CHEBI:60159	13917718	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	These data suggest that Y. _ pestis may produce OMVs during mammalian infection and we propose that dispersal of Pla via OMV release may influence the outcome of infection through interactions with Pla substrates such as plasminogen and Fas ligand .
10753888	0	Plakoglobin	0,11	BCL-2	67,72	Plakoglobin	BCL-2	null	596	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Plakoglobin regulates the expression of the anti-apoptotic protein BCL-2 .
12231560	0	Plasmin	0,7	Cyr61	16,21	Plasmin	Cyr61	null	16007(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Plasmin induces Cyr61 gene expression in fibroblasts via protease-activated receptor-1 and p44/42 mitogen-activated protein kinase-dependent signaling pathway .
1836639	0	Platelet_3H-paroxetine	0,22	serotonin_transporter	38,59	Platelet 3H-paroxetine	serotonin transporter	null	25553(Tax:10116)	Chemical	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	Platelet_3H-paroxetine binding to the serotonin_transporter is insensitive to changes in central serotonergic innervation in the rat .
20089227	0	Platelet_adenosine_diphosphate	0,30	P2Y12	31,36	Platelet adenosine diphosphate	P2Y12	null	64805	Chemical	Gene	antagonism|compound|START_ENTITY antagonism|compound|END_ENTITY	Platelet_adenosine_diphosphate P2Y12 receptor antagonism : benefits and limitations of current treatment strategies and future directions .
24624361	0	Platinum	10,18	BRCA	80,84	Platinum	BRCA	MESH:D010984	672	Chemical	Gene	Resistance|compound|START_ENTITY Resistance|dep|END_ENTITY	Reversing Platinum Resistance in High-Grade Serous Ovarian_Carcinoma : Targeting BRCA and the Homologous Recombination System .
25657199	0	Platinum	229,237	EGFR	191,195	Platinum	EGFR	MESH:D010984	1956	Chemical	Gene	Chemotherapy|compound|START_ENTITY Chemotherapy|compound|END_ENTITY	The Role of Smoking Status on the Progression-Free Survival of Non-Small_Cell_Lung_Cancer Patients Harboring Activating Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- Mutations Receiving First-Line EGFR Tyrosine Kinase Inhibitor Versus Platinum Doublet Chemotherapy : A Meta-Analysis of Prospective Randomized Trials .
19109741	0	Platonin	0,8	Akt	68,71	Platonin	Akt	MESH:C032149	207	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|preventing preventing|dobj|activation activation|nmod|END_ENTITY	Platonin inhibits LPS-induced NF-kappaB by preventing activation of Akt and IKKbeta in human PBMC .
16643232	0	Platonin	0,8	CAT-2	32,37	Platonin	CAT-2	MESH:C032149	111335(Tax:10090)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|END_ENTITY	Platonin attenuates LPS-induced CAT-2 and CAT-2B induction in stimulated murine macrophages .
20024897	0	Platycodin_D	0,12	Kruppel-like_factor_2_and_peroxisome_proliferator-activated_receptor_gamma	65,139	Platycodin D	Kruppel-like factor 2 and peroxisome proliferator-activated receptor gamma	MESH:C108953	19016(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Platycodin_D inhibits adipogenesis of 3T3-L1 cells by modulating Kruppel-like_factor_2_and_peroxisome_proliferator-activated_receptor_gamma .
2390929	0	Plaunotol	0,9	gastrin	32,39	Plaunotol	gastrin	MESH:C047686	2520	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|compound|END_ENTITY	Plaunotol inhibits postprandial gastrin release by its unique secretin-releasing action in humans .
2483390	0	Plaunotol	0,9	secretin	32,40	Plaunotol	secretin	MESH:C047686	24769(Tax:10116)	Chemical	Gene	stimulates|amod|START_ENTITY endogenous|nsubj|stimulates endogenous|dobj|release release|compound|END_ENTITY	Plaunotol stimulates endogenous secretin release and exocrine pancreatic secretion in rats .
26558155	0	Plecanatide	0,11	guanylate_cyclase-C	35,54	Plecanatide	guanylate cyclase-C	MESH:C584575	14917(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonists agonists|amod|END_ENTITY	Plecanatide and dolcanatide , novel guanylate_cyclase-C agonists , ameliorate gastrointestinal_inflammation in experimental models of murine colitis .
23839065	0	Pleurocidin	0,11	FPRL1	91,96	Pleurocidin	FPRL1	null	2358	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|receptor receptor|compound|END_ENTITY	Pleurocidin , a novel antimicrobial peptide , induces human mast cell activation through the FPRL1 receptor .
20420821	0	Plumbagin	0,9	ERK1/2	20,26	Plumbagin	ERK1/2	MESH:C014758	26417;26413	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Plumbagin activates ERK1/2 and Akt via superoxide , Src and PI3-kinase in 3T3-L1 cells .
19768635	0	Plumbagin	0,9	MMP-2	31,36	Plumbagin	MMP-2	MESH:C014758	4313	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Plumbagin inhibits TPA-induced MMP-2 and u-PA expressions by reducing binding activities of NF-kappaB and AP-1 via ERK signaling pathway in A549 human lung_cancer cells .
16624823	0	Plumbagin	0,9	NF-kappaB	61,70	Plumbagin	NF-kappaB	MESH:C014758	4790	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|activation activation|amod|END_ENTITY	Plumbagin -LRB- 5-hydroxy-2-methyl-1 ,4 - naphthoquinone -RRB- suppresses NF-kappaB activation and NF-kappaB-regulated gene products through modulation of p65 and IkappaBalpha kinase activation , leading to potentiation of apoptosis induced by cytokine and chemotherapeutic agents .
23991195	0	Plumbagin	0,9	NOX4	85,89	Plumbagin	NOX4	MESH:C014758	50490(Tax:10090)	Chemical	Gene	ameliorates|nsubj|START_ENTITY ameliorates|nmod|interruption interruption|nmod|pathways pathways|acl:relcl|include include|dobj|signalling signalling|compound|END_ENTITY	Plumbagin ameliorates diabetic_nephropathy via interruption of pathways that include NOX4 signalling .
25939783	0	Plumbagin	0,9	Nrf-2	71,76	Plumbagin	Nrf-2	MESH:C014758	18024(Tax:10090)	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|pathway pathway|compound|END_ENTITY	Plumbagin protects against glucocorticoid-induced osteoporosis through Nrf-2 pathway .
26273514	0	Plumbagin	23,32	STAT3	104,109	Plumbagin	STAT3	MESH:C014758	6774	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|Signaling Signaling|compound|END_ENTITY	Suppressive Effects of Plumbagin on Invasion and Migration of Breast_Cancer_Cells via the Inhibition of STAT3 Signaling and Down-regulation of Inflammatory Cytokine Expressions .
15339978	0	Podocalyxin	0,11	RhoA	22,26	Podocalyxin	RhoA	MESH:C001643	403954(Tax:9615)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Podocalyxin activates RhoA and induces actin reorganization through NHERF1 and Ezrin in MDCK cells .
20033853	0	Podophyllotoxin	0,15	CREB	24,28	Podophyllotoxin	CREB	MESH:D011034	1385	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Podophyllotoxin induces CREB phosphorylation and CRE-driven gene expression via PKA but not MAPKs .
22148433	0	Pol	38,41	p68	23,26	Pol	p68	null	10714	Chemical	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	Phosphorylation of the p68 subunit of Pol acts as a molecular switch to regulate its interaction with PCNA .
11282173	0	Policosanol	0,11	HMG-CoA_reductase	22,39	Policosanol	HMG-CoA reductase	MESH:C080710	3156	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activity activity|amod|END_ENTITY	Policosanol modulates HMG-CoA_reductase activity in cultured fibroblasts .
21054409	0	Poloxamer_407	0,13	lipase	27,33	Poloxamer 407	lipase	MESH:D020442	16891(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|compound|END_ENTITY	Poloxamer_407 as a general lipase inhibitor : its implications in lipid metabolism and atheroma formation in C57BL/6 mice .
3114909	0	Poly-D-lysine	0,13	tissue_plasminogen_activator	40,68	Poly-D-lysine	tissue plasminogen activator	CHEBI:61489	100128998	Chemical	Gene	inactivation|amod|START_ENTITY inactivation|nmod|END_ENTITY	Poly-D-lysine dependent inactivation of tissue_plasminogen_activator by a class PAI-2 inhibitor -LRB- minactivin -RRB- .
24077684	0	Poly-y-glutamate	0,16	tyrosinase	49,59	Poly-y-glutamate	tyrosinase	null	22173(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Poly-y-glutamate from Bacillus_subtilis inhibits tyrosinase activity and melanogenesis .
16872633	0	Poly_ADP-Ribose	28,43	PARP	56,60	Poly ADP-Ribose	PARP	MESH:D011064	11545(Tax:10090)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Local administration of the Poly_ADP-Ribose Polymerase -LRB- PARP -RRB- inhibitor , PJ34 during hindlimb ischemia modulates skeletal muscle reperfusion injury .
23970645	0	Polyactin_A	0,11	CD4	22,25	Polyactin A	CD4	MESH:C064233	920	Chemical	Gene	increases|compound|START_ENTITY END_ENTITY|nsubj|increases	Polyactin_A increases CD4 -LRB- + -RRB- T-cell counts in HIV-infected individuals with insufficient immunologic response to highly active antiretroviral therapy .
15385446	0	Polyalanine	0,11	HOXA13	25,31	Polyalanine	HOXA13	MESH:C019529	15398(Tax:10090)	Chemical	Gene	expansion|amod|START_ENTITY expansion|nmod|END_ENTITY	Polyalanine expansion in HOXA13 : three new affected families and the molecular consequences in a mouse model .
12640453	0	Polyalanine	0,11	PHOX2B	80,86	Polyalanine	PHOX2B	MESH:C019529	8929	Chemical	Gene	expansion|amod|START_ENTITY expansion|nmod|END_ENTITY	Polyalanine expansion and frameshift mutations of the paired-like homeobox gene PHOX2B in congenital_central_hypoventilation_syndrome .
19881470	0	Polyalanine	0,11	PHOX2B	25,31	Polyalanine	PHOX2B	MESH:C019529	8929	Chemical	Gene	expansion|amod|START_ENTITY expansion|nmod|END_ENTITY	Polyalanine expansion of PHOX2B in congenital_central_hypoventilation_syndrome : rs17884724 : A > C is associated with 7-alanine expansion .
22125732	0	Polyalanine	66,77	PHOX2B	111,117	Polyalanine	PHOX2B	MESH:C019529	8929	Chemical	Gene	Expansion|compound|START_ENTITY Expansion|acl|Mutation Mutation|nmod|Gene Gene|compound|END_ENTITY	Late Onset Central Hypoventilation_Syndrome due to a Heterozygous Polyalanine Repeat Expansion Mutation in the PHOX2B Gene .
17127446	0	Polyalanine	0,11	SOX3	69,73	Polyalanine	SOX3	MESH:C019529	6658	Chemical	Gene	mutations|amod|START_ENTITY mutations|nmod|END_ENTITY	Polyalanine expansion mutations in the X-linked_hypopituitarism gene SOX3 result in aggresome formation and impaired transactivation .
25938472	0	Polyamide	59,68	TGF-b1	85,91	Polyamide	TGF-b1	CHEBI:61445	7040	Chemical	Gene	Promoter|compound|START_ENTITY Promoter|compound|END_ENTITY	Preclinical Study of Novel Gene Silencer Pyrrole-Imidazole Polyamide Targeting Human TGF-b1 Promoter for Hypertrophic_Scars in a Common_Marmoset Primate Model .
25961839	0	Polyamine	11,20	Antizyme_Inhibitor_1	37,57	Polyamine	Antizyme Inhibitor 1	CHEBI:60143	58961(Tax:10116)	Chemical	Gene	Biosynthesis|compound|START_ENTITY Biosynthesis|nmod|END_ENTITY	Control of Polyamine Biosynthesis by Antizyme_Inhibitor_1 Is Important for Transcriptional Regulation of Arginine_Vasopressin in the Male Rat Hypothalamus .
7055448	0	Polyamine	0,9	CSF	20,23	Polyamine	CSF	CHEBI:60143	1437	Chemical	Gene	levels|amod|START_ENTITY levels|nmod|END_ENTITY	Polyamine levels in CSF from patients with pituitary_tumors or nonneoplastic pituitary_disease .
17218313	0	Polyamine	0,9	DUR3	20,24	Polyamine	DUR3	CHEBI:60143	856370(Tax:4932)	Chemical	Gene	uptake|nsubj|START_ENTITY uptake|nmod|END_ENTITY	Polyamine uptake by DUR3 and SAM3 in Saccharomyces_cerevisiae .
8484773	0	Polyamine	0,9	S-adenosylmethionine_decarboxylase	24,58	Polyamine	S-adenosylmethionine decarboxylase	CHEBI:60143	11702(Tax:10090)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|synthesis synthesis|amod|END_ENTITY	Polyamine regulation of S-adenosylmethionine_decarboxylase synthesis through the 5 ' - untranslated region of its mRNA .
25623305	0	Polyamine	8,17	SpeG	37,41	Polyamine	SpeG	CHEBI:60143	10290	Chemical	Gene	Site|compound|START_ENTITY Site|nmod|END_ENTITY	A Novel Polyamine Allosteric Site of SpeG from Vibrio_cholerae Is Revealed by Its Dodecameric Structure .
513005	0	Polyamine	0,9	acrosin	62,69	Polyamine	acrosin	CHEBI:60143	49	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Polyamine inhibition of the conversion of human proacrosin to acrosin .
7972938	0	Polyamine	0,9	atrial_natriuretic_peptide	24,50	Polyamine	atrial natriuretic peptide	CHEBI:60143	24602(Tax:10116)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Polyamine regulation of atrial_natriuretic_peptide in cultured cardiocytes .
1953763	0	Polyamine	0,9	casein_kinase_II	30,46	Polyamine	casein kinase II	CHEBI:60143	1457	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Polyamine binding activity of casein_kinase_II .
9598871	0	Polyamine	0,9	estrogen_receptor	24,41	Polyamine	estrogen receptor	CHEBI:60143	2099	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Polyamine inhibition of estrogen_receptor -LRB- ER -RRB- DNA-binding and ligand-binding functions .
11123206	0	Polyamine	0,9	ornithine_decarboxylase	24,47	Polyamine	ornithine decarboxylase	CHEBI:60143	24609(Tax:10116)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Polyamine regulation of ornithine_decarboxylase and its antizyme in intestinal epithelial cells .
14688243	0	Polyamine	0,9	ornithine_decarboxylase	58,81	Polyamine	ornithine decarboxylase	CHEBI:60143	4953	Chemical	Gene	homeostasis|amod|START_ENTITY homeostasis|nmod|plants plants|acl|overexpressing overexpressing|dobj|END_ENTITY	Polyamine homeostasis in transgenic plants overexpressing ornithine_decarboxylase includes ornithine limitation .
1573975	0	Polyamine	0,9	ornithine_decarboxylase	18,41	Polyamine	ornithine decarboxylase	CHEBI:60143	4953	Chemical	Gene	levels|amod|START_ENTITY levels|appos|activity activity|amod|END_ENTITY	Polyamine levels , ornithine_decarboxylase -LRB- ODC -RRB- activity , and ODC-mRNA expression in normal and cancerous human colonocytes .
20406645	0	Polyamine	0,9	ornithine_decarboxylase	86,109	Polyamine	ornithine decarboxylase	CHEBI:60143	4953	Chemical	Gene	biosynthesis|amod|START_ENTITY biosynthesis|dep|characterisation characterisation|nmod|END_ENTITY	Polyamine biosynthesis in Phytomonas : biochemical characterisation of a very unstable ornithine_decarboxylase .
7749159	0	Polyamine	0,9	ornithine_decarboxylase	44,67	Polyamine	ornithine decarboxylase	CHEBI:60143	4953	Chemical	Gene	profiles|amod|START_ENTITY profiles|nmod|cells cells|amod|END_ENTITY	Polyamine profiles and growth properties of ornithine_decarboxylase overexpressing MCF-7_breast_cancer cells in culture .
11578527	0	Polyamine	0,9	pro-opiomelanocortin	32,52	Polyamine	pro-opiomelanocortin	CHEBI:60143	24664(Tax:10116)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Polyamine regulation of the rat pro-opiomelanocortin gene expression in AtT-20 cells .
12869386	0	Polyamines	0,10	TNF-alpha	97,106	Polyamines	TNF-alpha	MESH:D011073	24835(Tax:10116)	Chemical	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	Polyamines are required for activation of c-Jun_NH2-terminal_kinase and apoptosis in response to TNF-alpha in IEC-6 cells .
26680812	0	Polyamines	11,21	TNFalpha	25,33	Polyamines	TNFalpha	MESH:D011073	7124	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of Polyamines on TNFalpha - or Tamoxifen-induced Apoptosis in Human Breast_Cancer Cells .
3301411	0	Polyamines	0,10	histone_deacetylase	29,48	Polyamines	histone deacetylase	MESH:D011073	855987(Tax:4932)	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|END_ENTITY	Polyamines inhibit the yeast histone_deacetylase .
8114757	0	Polyamines	0,10	ornithine_decarboxylase	134,157	Polyamines	ornithine decarboxylase	MESH:D011073	4953	Chemical	Gene	START_ENTITY|dep|stimulation stimulation|nmod|spermatogonia spermatogonia|nmod|transgenic_mice transgenic_mice|acl|overexpressing overexpressing|dobj|gene gene|compound|END_ENTITY	Polyamines and regulation of spermatogenesis : selective stimulation of late spermatogonia in transgenic_mice overexpressing the human ornithine_decarboxylase gene .
8171019	0	Polyamines	0,10	ornithine_decarboxylase	38,61	Polyamines	ornithine decarboxylase	MESH:D011073	4953	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|nmod|antizyme antizyme|amod|END_ENTITY	Polyamines regulate the expression of ornithine_decarboxylase antizyme in vitro by inducing ribosomal frame-shifting .
9428668	0	Polyamines	0,10	ornithine_decarboxylase	76,99	Polyamines	ornithine decarboxylase	MESH:D011073	18263(Tax:10090)	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|transcription transcription|nmod|gene gene|acl|encoding encoding|dobj|antizyme antizyme|amod|END_ENTITY	Polyamines regulate both transcription and translation of the gene encoding ornithine_decarboxylase antizyme in mouse .
15371436	0	Polyarginine	0,12	furin	42,47	Polyarginine	furin	MESH:C015462	5045	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Polyarginine inhibits gp160 processing by furin and suppresses productive human_immunodeficiency_virus_type_1_infection .
15371436	0	Polyarginine	0,12	gp160	22,27	Polyarginine	gp160	MESH:C015462	155971(Tax:11676)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|processing processing|amod|END_ENTITY	Polyarginine inhibits gp160 processing by furin and suppresses productive human_immunodeficiency_virus_type_1_infection .
7017095	0	Polycarbonate	71,84	part_1	63,69	Polycarbonate	part 1	CHEBI:61433	25859	Chemical	Gene	START_ENTITY|nsubj|study study|appos|END_ENTITY	A study on the dental injection molding system with cartridge -LRB- part_1 -RRB- Polycarbonate denture base .
17692354	0	Polychlorinated_biphenyl	0,24	CYP3A4	44,50	Polychlorinated biphenyl	CYP3A4	null	1576	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Polychlorinated_biphenyl -LRB- PCB -RRB- induction of CYP3A4 enzyme activity in healthy Faroese adults .
27008339	0	Polydimethylsiloxane	0,20	CD38	38,42	Polydimethylsiloxane	CD38	MESH:C013830	952	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|compound|END_ENTITY	Polydimethylsiloxane -LRB- PDMS -RRB- modulates CD38 expression , absorbs retinoic_acid and may perturb retinoid signalling .
1482652	0	Polyethylene_glycol	0,19	granulocyte-macrophage_colony_stimulating_factor	42,90	Polyethylene glycol	granulocyte-macrophage colony stimulating factor	MESH:D011092	1437	Chemical	Gene	modification|amod|START_ENTITY modification|nmod|END_ENTITY	Polyethylene_glycol -LRB- PEG -RRB- modification of granulocyte-macrophage_colony_stimulating_factor -LRB- GM-CSF -RRB- enhances neutrophil priming activity but not colony stimulating activity .
18502120	0	Polyethylene_glycol	0,19	peroxidase	66,76	Polyethylene glycol	peroxidase	MESH:D011092	106444911	Chemical	Gene	improves|nsubj|START_ENTITY improves|nmod|END_ENTITY	Polyethylene_glycol improves phenol removal by immobilized turnip peroxidase .
25866054	0	Polyethylenimine	96,112	PD-L1	35,40	Polyethylenimine	PD-L1	MESH:D011094	574058(Tax:9823)	Chemical	Gene	Delivery|nmod|START_ENTITY Delivery|compound|END_ENTITY	Ovarian_Cancer Immunotherapy Using PD-L1 siRNA Targeted Delivery from Folic_Acid-Functionalized Polyethylenimine : Strategies to Enhance T Cell Killing .
1092343	0	Polyfluoroalkylamine	0,20	luteinizing_hormone-releasing_hormone	36,73	Polyfluoroalkylamine	luteinizing hormone-releasing hormone	null	25194(Tax:10116)	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Polyfluoroalkylamine derivatives of luteinizing_hormone-releasing_hormone .
25761689	0	Polyglutamic_Acid	132,149	Histone_H1	14,24	Polyglutamic Acid	Histone H1	MESH:D011099	24437(Tax:10116)	Chemical	Gene	Extraction|nmod|START_ENTITY Extraction|nmod|END_ENTITY	Extraction of Histone_H1 and Decondensation of Nuclear Chromatin with Various Mg-Dependent Organization Levels under Treatment with Polyglutamic_Acid and Distamycin .
11719253	0	Polyglutamine	0,13	androgen_receptor	37,54	Polyglutamine	androgen receptor	MESH:C097188	367	Chemical	Gene	expansion|amod|START_ENTITY expansion|nmod|END_ENTITY	Polyglutamine tract expansion of the androgen_receptor in a motoneuronal model of spinal_and_bulbar_muscular_atrophy .
15345714	0	Polyglutamine	0,13	ataxin-3	27,35	Polyglutamine	ataxin-3	MESH:C097188	4287	Chemical	Gene	expansion|amod|START_ENTITY expansion|nmod|END_ENTITY	Polyglutamine expansion in ataxin-3 does not affect protein stability : implications for misfolding and disease .
21740957	0	Polyglutamine	0,13	ataxin-3	44,52	Polyglutamine	ataxin-3	MESH:C097188	4287	Chemical	Gene	diseases|amod|START_ENTITY diseases|dep|case case|nmod|END_ENTITY	Polyglutamine diseases : the special case of ataxin-3 and Machado-Joseph_disease .
15654337	0	Polyglutamine	0,13	huntingtin	27,37	Polyglutamine	huntingtin	MESH:C097188	15194(Tax:10090)	Chemical	Gene	expansion|amod|START_ENTITY expansion|nmod|END_ENTITY	Polyglutamine expansion of huntingtin impairs its nuclear export .
19566678	0	Polyglutamine	0,13	huntingtin	27,37	Polyglutamine	huntingtin	MESH:C097188	15194(Tax:10090)	Chemical	Gene	expansion|amod|START_ENTITY expansion|nmod|END_ENTITY	Polyglutamine expansion in huntingtin alters its interaction with phospholipids .
19607813	0	Polyglutamine	0,13	huntingtin	27,37	Polyglutamine	huntingtin	MESH:C097188	3064	Chemical	Gene	expansion|amod|START_ENTITY expansion|nmod|END_ENTITY	Polyglutamine expansion in huntingtin increases its insertion into lipid bilayers .
16168961	0	Polyhistidine	0,13	HOXA1	34,39	Polyhistidine	HOXA1	null	3198	Chemical	Gene	expansions|amod|START_ENTITY expansions|nmod|END_ENTITY	Polyhistidine tract expansions in HOXA1 result in intranuclear aggregation and increased cell death .
16158333	0	Polyinosinic_acid	0,17	TNF_and_NO	26,36	Polyinosinic acid	TNF and NO	null	21926(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|compound|END_ENTITY	Polyinosinic_acid induces TNF_and_NO production as well as NF-kappaB and AP-1 transcriptional activation in the monocytemacrophage cell line RAW 264.7 .
25755662	0	Polyol	0,6	sorbitol_dehydrogenase	55,77	Polyol	sorbitol dehydrogenase	CHEBI:26191	829452(Tax:3702)	Chemical	Gene	specificity|amod|START_ENTITY specificity|nmod|END_ENTITY	Polyol specificity of recombinant Arabidopsis_thaliana sorbitol_dehydrogenase studied by enzyme kinetics and in silico modeling .
11060043	0	Polypeptide	0,11	Hsp90	23,28	Polypeptide	Hsp90	CHEBI:15841	3320	Chemical	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	Polypeptide release by Hsp90 involves ATP hydrolysis and is enhanced by the co-chaperone p23 .
11843182	0	Polyphenols	0,11	15-lipoxygenase	46,61	Polyphenols	15-lipoxygenase	MESH:D059808	246	Chemical	Gene	START_ENTITY|dep|inhibition inhibition|nmod|END_ENTITY	Polyphenols of cocoa : inhibition of mammalian 15-lipoxygenase .
26996169	0	Polyphenols	32,43	AChE	61,65	Polyphenols	AChE	MESH:D059808	43	Chemical	Gene	START_ENTITY|nmod|Inhibitors Inhibitors|nmod|END_ENTITY	In Silico Analysis of Green Tea Polyphenols as Inhibitors of AChE and BChE enzymes in Alzheimer 's _ disease Treatment .
21191472	0	Polyphenols	72,83	COMT	32,36	Polyphenols	COMT	MESH:D059808	1312	Chemical	Gene	Genotype|nmod|START_ENTITY Genotype|compound|END_ENTITY	Genetic Association Between the COMT Genotype and Urinary Levels of Tea Polyphenols and Their Metabolites among Daily Green Tea Drinkers .
26112149	0	Polyphenols	272,283	GAPDH	242,247	Polyphenols	GAPDH	MESH:D059808	2597	Chemical	Gene	Induced|nmod|START_ENTITY Induced|compound|END_ENTITY	Analysis of Potential Binding Sites of 3,5,4 ' - trihydroxystilbene -LRB- Resveratrol -RRB- and Trans-3 ,3 ' ,5,5 ' - tetrahydroxy-4 ' - methoxystilbene -LRB- THMS -RRB- to the GAPDH Molecule Using a Computational Ligand-docking Method : Structural and Functional Changes in GAPDH Induced by the Examined Polyphenols .
26863418	0	Polyphenols	57,68	MDM2	38,42	Polyphenols	MDM2	MESH:D059808	4193	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|compound|END_ENTITY	Hydrophobic Interactions Are a Key to MDM2 Inhibition by Polyphenols as Revealed by Molecular Dynamics Simulations and MM/PBSA Free Energy Calculations .
17379280	0	Polyphenols	0,11	PAI-1	25,30	Polyphenols	PAI-1	MESH:D059808	5054	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Polyphenols downregulate PAI-1 gene expression in cultured human coronary artery endothelial cells : molecular contributor to cardiovascular protection .
23231348	0	Polyphenols	0,11	furin	24,29	Polyphenols	furin	MESH:D059808	5045	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|END_ENTITY	Polyphenols can inhibit furin in vitro as a result of the reactivity of their auto-oxidation products to proteins .
19147768	0	Polyphenon_E	0,12	cyclin_D1	106,115	Polyphenon E	cyclin D1	MESH:C472086	595	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|suppressing suppressing|dobj|expression expression|amod|END_ENTITY	Polyphenon_E inhibits the growth of human Barrett 's and aerodigestive adenocarcinoma cells by suppressing cyclin_D1 expression .
23006049	0	Polyphosphate	0,13	von_Willebrand_factor	29,50	Polyphosphate	von Willebrand factor	CHEBI:16838	7450	Chemical	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Polyphosphate binds to human von_Willebrand_factor in vivo and modulates its interaction with glycoprotein Ib .
15669107	0	Polypyrimidine	0,14	PTB	38,41	Polypyrimidine	PTB	null	5725	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Polypyrimidine tract-binding protein -LRB- PTB -RRB- inhibits Hepatitis_C_virus internal ribosome entry site -LRB- HCV IRES -RRB- - mediated translation , but does not affect HCV replication .
18499661	0	Polypyrimidine	0,14	PTB	38,41	Polypyrimidine	PTB	null	5725	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Polypyrimidine tract-binding protein -LRB- PTB -RRB- differentially affects malignancy in a cell line-dependent manner .
25745457	0	Polysaccharides	26,41	endothelin-1	63,75	Polysaccharides	endothelin-1	MESH:D011134	24323(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effect of Lycium barbarum Polysaccharides on the expression of endothelin-1 and its receptors in an ocular_hypertension model of rat glaucoma .
9231707	0	Polysialic_acid	0,15	STX	36,39	Polysialic acid	STX	MESH:C021319	20450(Tax:10090)	Chemical	Gene	synthase|nsubj|START_ENTITY synthase|xcomp|expression expression|dep|END_ENTITY	Polysialic_acid synthase -LRB- ST8Sia_II / STX -RRB- mRNA expression in the developing mouse central nervous system .
25863442	0	Polysialic_acid	0,15	SynCAM_1	68,76	Polysialic acid	SynCAM 1	MESH:C021319	23705	Chemical	Gene	modification|amod|START_ENTITY modification|nmod|END_ENTITY	Polysialic_acid modification of the synaptic cell adhesion molecule SynCAM_1 in human embryonic stem cell-derived oligodendrocyte precursor cells .
13679364	0	Polysialic_acid	0,15	neural_cell_adhesion_molecule	48,77	Polysialic acid	neural cell adhesion molecule	MESH:C021319	4684	Chemical	Gene	o-glycans|amod|START_ENTITY o-glycans|nmod|END_ENTITY	Polysialic_acid and mucin type o-glycans on the neural_cell_adhesion_molecule differentially regulate myoblast fusion .
26728928	0	Polyunsaturated_Fatty_Acids	60,87	C-Reactive_Protein	20,38	Polyunsaturated Fatty Acids	C-Reactive Protein	MESH:D005231	1401	Chemical	Gene	Levels|nmod|START_ENTITY END_ENTITY|nmod|Levels	The Associations of C-Reactive_Protein with Serum Levels of Polyunsaturated_Fatty_Acids and Trans_Fatty_Acids Among Middle-Aged Men from Three Populations .
26402697	0	Polyunsaturated_Fatty_Acids	15,42	Mcp-1	46,51	Polyunsaturated Fatty Acids	Mcp-1	MESH:D005231	24770(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|Expression Expression|compound|END_ENTITY	Duality of n-3 Polyunsaturated_Fatty_Acids on Mcp-1 Expression in Vascular Smooth Muscle : A Potential Role of 4-Hydroxy_Hexenal .
9814727	0	Polyunsaturated_fatty_acids	0,27	IgE	80,83	Polyunsaturated fatty acids	IgE	MESH:D005231	3497	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Polyunsaturated_fatty_acids in school children in relation to allergy and serum IgE levels .
17472580	0	Polyunsaturated_fatty_acids	0,27	NOX_4	37,42	Polyunsaturated fatty acids	NOX 4	MESH:D005231	50507	Chemical	Gene	modulate|nsubj|START_ENTITY modulate|dobj|production production|compound|END_ENTITY	Polyunsaturated_fatty_acids modulate NOX_4 anion superoxide production in human fibroblasts .
11701434	0	Polyunsaturated_fatty_acids	0,27	UCP-2	46,51	Polyunsaturated fatty acids	UCP-2	MESH:D005231	7351	Chemical	Gene	stimulate|nsubj|START_ENTITY stimulate|dobj|expression expression|compound|END_ENTITY	Polyunsaturated_fatty_acids stimulate hepatic UCP-2 expression via a PPARalpha-mediated pathway .
8729090	0	Polyunsaturated_fatty_acids	0,27	stearoyl-CoA_desaturase-1	44,69	Polyunsaturated fatty acids	stearoyl-CoA desaturase-1	MESH:D005231	20249(Tax:10090)	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|gene gene|amod|END_ENTITY	Polyunsaturated_fatty_acids inhibit hepatic stearoyl-CoA_desaturase-1 gene in diabetic mice .
25676419	0	Ponatinib	0,9	ABCB1	32,37	Ponatinib	ABCB1	MESH:C545373	5243	Chemical	Gene	transported|nsubjpass|START_ENTITY transported|nmod|END_ENTITY	Ponatinib is not transported by ABCB1 , ABCG2 or OCT-1 in CML cells .
19540306	0	Porcine	0,7	DAZL	8,12	Porcine	DAZL	null	1618	Chemical	Gene	RNA|compound|START_ENTITY RNA|compound|END_ENTITY	Porcine DAZL messenger RNA : its expression and regulation during oocyte maturation .
9453240	0	Porcine	0,7	Dax-1	8,13	Porcine	Dax-1	null	190	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Porcine Dax-1 gene : isolation and expression during gonadal development .
11792426	0	Porcine	0,7	Fas-ligand	8,18	Porcine	Fas-ligand	null	396726(Tax:9823)	Chemical	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Porcine Fas-ligand gene : genomic sequence analysis and comparison with human gene .
19124157	0	Porcine	0,7	Fc_gammaRIII	8,20	Porcine	Fc gammaRIII	null	2214	Chemical	Gene	isoforms|compound|START_ENTITY isoforms|compound|END_ENTITY	Porcine Fc_gammaRIII isoforms are generated by alternative splicing .
20477789	0	Porcine	0,7	NAMPT	8,13	Porcine	NAMPT	null	595123(Tax:9823)	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Porcine NAMPT gene : search for polymorphism , mapping and association studies .
12420294	2	Porcine	341,348	PAFr	349,353	Porcine	PAFr	null	5724	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Porcine PAFr gene was mapped using fluorescence in situ hybridization -LRB- FISH -RRB- .
26430891	0	Porcine	0,7	SOX9	8,12	Porcine	SOX9	null	396840(Tax:9823)	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Porcine SOX9 Gene Expression Is Influenced by an 18bp Indel in the 5 ' - Untranslated Region .
12606467	0	Porcine	0,7	SRY	8,11	Porcine	SRY	null	100625818	Chemical	Gene	promoter|compound|START_ENTITY promoter|compound|END_ENTITY	Porcine SRY promoter is a target for steroidogenic_factor_1 .
25775247	0	Porcine	42,49	VIII	57,61	Porcine	VIII	null	1351	Chemical	Gene	Domain|compound|START_ENTITY Domain|compound|END_ENTITY	The 1.7 X-Ray Crystal Structure of the Porcine Factor VIII C2 Domain and Binding Analysis to Anti-Human C2 Domain Antibodies and Phospholipid Surfaces .
7711170	0	Porcine	0,7	calbindin-D9k	8,21	Porcine	calbindin-D9k	null	397265(Tax:9823)	Chemical	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Porcine calbindin-D9k gene : expression in endometrium , myometrium , and placenta in the absence of a functional estrogen response element in intron A .
3045144	0	Porcine	0,7	insulin	18,25	Porcine	insulin	null	3630	Chemical	Gene	absorption|compound|START_ENTITY absorption|compound|END_ENTITY	Porcine and human insulin absorption from subcutaneous tissues in normal and insulin-dependent diabetic subjects : a deconvolution-based approach .
17516469	0	Porphomethene	0,13	uroporphyrinogen_decarboxylase	27,57	Porphomethene	uroporphyrinogen decarboxylase	null	7389	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|nmod|END_ENTITY	Porphomethene inhibitor of uroporphyrinogen_decarboxylase : analysis by high-performance liquid chromatography/electrospray ionization tandem mass spectrometry .
23904743	0	Porphyrin	0,9	acetylcholinesterase	40,60	Porphyrin	acetylcholinesterase	CHEBI:8337	41625(Tax:7227)	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|inhibitors inhibitors|nmod|END_ENTITY	Porphyrin derivatives as inhibitors for acetylcholinesterase from Drosophila_melanogaster .
1938617	0	Poststatin	0,10	prolyl_endopeptidase	31,51	Poststatin	prolyl endopeptidase	MESH:C071400	19072(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Poststatin , a new inhibitor of prolyl_endopeptidase , produced by Streptomyces viridochromogenes MH534-30F3 .
8626246	0	Poststatin	0,10	prolyl_endopeptidase	31,51	Poststatin	prolyl endopeptidase	MESH:C071400	5550	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Poststatin , a new inhibitor of prolyl_endopeptidase .
8931723	0	Poststatin	0,10	prolyl_endopeptidase	31,51	Poststatin	prolyl endopeptidase	MESH:C071400	5550	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Poststatin , a new inhibitor of prolyl_endopeptidase .
8931724	0	Poststatin	0,10	prolyl_endopeptidase	31,51	Poststatin	prolyl endopeptidase	MESH:C071400	5550	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Poststatin , a new inhibitor of prolyl_endopeptidase .
8931725	0	Poststatin	0,10	prolyl_endopeptidase	31,51	Poststatin	prolyl endopeptidase	MESH:C071400	5550	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Poststatin , a new inhibitor of prolyl_endopeptidase .
8968396	0	Poststatin	0,10	prolyl_endopeptidase	31,51	Poststatin	prolyl endopeptidase	MESH:C071400	5550	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Poststatin , a new inhibitor of prolyl_endopeptidase .
10352038	0	Potassium	0,9	AKT1	59,63	Potassium	AKT1	MESH:D011188	817206(Tax:3702)	Chemical	Gene	uptake|nsubj|START_ENTITY uptake|xcomp|supporting supporting|dobj|growth growth|nmod|absence absence|nmod|activity activity|compound|END_ENTITY	Potassium uptake supporting plant growth in the absence of AKT1 channel activity : Inhibition by ammonium and stimulation by sodium .
16667576	0	Potassium	0,9	ATPase	47,53	Potassium	ATPase	MESH:D011188	100285773(Tax:4577)	Chemical	Gene	Stimulation|compound|START_ENTITY Stimulation|nmod|END_ENTITY	Potassium Stimulation of Corn Root Plasmalemma ATPase : II .
7836457	1	Potassium	72,81	ATPase	106,112	Potassium	ATPase	MESH:D011188	1769	Chemical	Gene	required|nsubjpass|START_ENTITY required|nmod|activity activity|amod|END_ENTITY	I. Potassium is required for optimal ATPase activity .
27021102	0	Potassium	13,22	BKCa	8,12	Potassium	BKCa	MESH:D011188	83731(Tax:10116)	Chemical	Gene	Channels|compound|START_ENTITY Channels|compound|END_ENTITY	Role of BKCa Potassium Channels in the Mechanisms of Modulatory Effects of IL-10 on Hypoxia-Induced Changes in Activity of Hippocampal Neurons .
10686402	0	Potassium	0,9	CA1	22,25	Potassium	CA1	MESH:D011188	310218(Tax:10116)	Chemical	Gene	currents|amod|START_ENTITY currents|nmod|neurons neurons|nummod|END_ENTITY	Potassium currents in CA1 neurons of rat hippocampus increase shortly after transient cerebral_ischemia .
11376889	0	Potassium	0,9	CA1	39,42	Potassium	CA1	MESH:D011188	310218(Tax:10116)	Chemical	Gene	TEA|amod|START_ENTITY prevents|nsubj|TEA prevents|dobj|hippocampal_injury hippocampal_injury|nummod|END_ENTITY	Potassium channel blocker TEA prevents CA1 hippocampal_injury following transient forebrain_ischemia in adult rats .
23554830	0	Potassium	47,56	CA1	84,87	Potassium	CA1	MESH:D011188	310218(Tax:10116)	Chemical	Gene	Current|compound|START_ENTITY Current|nmod|Neurons Neurons|compound|END_ENTITY	Saikosaponin_a Enhances Transient Inactivating Potassium Current in Rat Hippocampal CA1 Neurons .
7651611	0	Potassium	0,9	CA1	31,34	Potassium	CA1	MESH:D011188	310218(Tax:10116)	Chemical	Gene	currents|amod|START_ENTITY currents|nmod|neurons neurons|compound|END_ENTITY	Potassium currents in isolated CA1 neurons of the rat after kindling epileptogenesis .
7697882	0	Potassium	0,9	CA1	64,67	Potassium	CA1	MESH:D011188	310218(Tax:10116)	Chemical	Gene	currents|amod|START_ENTITY isolated|nsubj|currents isolated|xcomp|maturing maturing|dobj|neurones neurones|compound|END_ENTITY	Potassium currents in acutely isolated maturing rat hippocampal CA1 neurones .
7830942	0	Potassium	0,9	CA1	160,163	Potassium	CA1	MESH:D011188	310218(Tax:10116)	Chemical	Gene	involvement|compound|START_ENTITY involvement|nmod|region region|compound|END_ENTITY	Potassium and calcium channel involvement in induction of long-lasting synaptic enhancement by calyculin_A , a protein phosphatase inhibitor , in rat hippocampal CA1 region .
8145166	0	Potassium	0,9	CA1	77,80	Potassium	CA1	MESH:D011188	310218(Tax:10116)	Chemical	Gene	currents|amod|START_ENTITY operated|nsubj|currents operated|nmod|neurones neurones|compound|END_ENTITY	Potassium currents operated by thyrotrophin-releasing_hormone in dissociated CA1 pyramidal neurones of rat hippocampus .
8576856	0	Potassium	0,9	CA1	84,87	Potassium	CA1	MESH:D011188	310218(Tax:10116)	Chemical	Gene	conductances|nsubj|START_ENTITY conductances|nmod|interneurones interneurones|compound|END_ENTITY	Potassium conductances underlying repolarization and after-hyperpolarization in rat CA1 hippocampal interneurones .
9819250	0	Potassium	0,9	CA1	51,54	Potassium	CA1	MESH:D011188	310218(Tax:10116)	Chemical	Gene	conductance|nsubj|START_ENTITY conductance|xcomp|causing causing|dobj|hyperpolarization hyperpolarization|nmod|neurons neurons|nummod|END_ENTITY	Potassium conductance causing hyperpolarization of CA1 hippocampal neurons during hypoxia .
21655370	0	Potassium	30,39	GIRK1	51,56	Potassium	GIRK1	MESH:D011188	3760	Chemical	Gene	Channel|compound|START_ENTITY Channel|appos|END_ENTITY	G-Protein Inwardly Rectifying Potassium Channel 1 -LRB- GIRK1 -RRB- Knockdown Decreases Beta-Adrenergic , MAP Kinase and Akt Signaling in the MDA-MB-453 Breast_Cancer Cell Line .
27021102	0	Potassium	13,22	IL-10	75,80	Potassium	IL-10	MESH:D011188	25325(Tax:10116)	Chemical	Gene	Channels|compound|START_ENTITY Role|nmod|Channels Role|nmod|END_ENTITY	Role of BKCa Potassium Channels in the Mechanisms of Modulatory Effects of IL-10 on Hypoxia-Induced Changes in Activity of Hippocampal Neurons .
26626290	0	Potassium	44,53	JNK	106,109	Potassium	JNK	MESH:D011188	26419(Tax:10090)	Chemical	Gene	Tolerance|compound|START_ENTITY Tolerance|nmod|END_ENTITY	Opening of Adenosine_Triphosphate-Sensitive Potassium Channel Attenuates Morphine Tolerance by Inhibiting JNK and Astrocyte Activation in the Spinal Cord .
22315453	0	Potassium	0,9	KCNJ5	25,30	Potassium	KCNJ5	MESH:D011188	3762	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Potassium channel mutant KCNJ5 T158A expression in HAC-15 cells increases aldosterone synthesis .
23658958	0	Potassium	63,72	KCNK9	82,87	Potassium	KCNK9	MESH:D011188	51305	Chemical	Gene	Channel|compound|START_ENTITY Inhibitor|nmod|Channel Development|nmod|Inhibitor subfamily|nsubj|Development subfamily|parataxis|identified identified|nsubjpass|ML308 ML308|compound|END_ENTITY	Development of a Selective Chemical Inhibitor for the Two-Pore Potassium Channel , KCNK9 ML308 was identified as a novel inhibitor of the potassium channel , subfamily K , member 9 -LRB- KCNK9 -RRB- two-pore domain potassium channel .
26100633	0	Potassium	51,60	KCNT2	76,81	Potassium	KCNT2	MESH:D011188	304827(Tax:10116)	Chemical	Gene	promoter|compound|START_ENTITY promoter|appos|END_ENTITY	Transcriptional Regulation of the Sodium-activated Potassium Channel SLICK -LRB- KCNT2 -RRB- promoter by nuclear factor-kappa B. UNASSIGNED : Although recent studies have shown the sodium-activated potassium channel SLACK -LRB- KCNT1 -RRB- can contribute to neuronal excitability , there remains little information on the physiological role of the closely related SLICK -LRB- KCNT2 -RRB- channel .
21433378	0	Potassium	158,167	ROMK	43,47	Potassium	ROMK	MESH:D011188	3758	Chemical	Gene	Channel|compound|START_ENTITY inhibitors|nmod|Channel identify|dobj|inhibitors is|xcomp|identify is|nsubj|Discovery Discovery|nmod|inhibitor inhibitor|nmod|END_ENTITY	Discovery of a small molecule inhibitor of ROMK and Kir7 .1 The specific aim of this project is to identify small molecule inhibitors of Renal Outer Medullary Potassium Channel -LRB- ROMK , Kir1 .1 , KCNJ1 -RRB- , a potassium channel located in the renal tubule , where it critically regulates sodium and potassium balance .
21433391	0	Potassium	178,187	ROMK	43,47	Potassium	ROMK	MESH:D011188	3758	Chemical	Gene	Channel|compound|START_ENTITY inhibitors|nmod|Channel identify|dobj|inhibitors is|xcomp|identify is|nsubj|Discovery Discovery|nmod|inhibitor inhibitor|nmod|END_ENTITY	Discovery of a small molecule inhibitor of ROMK with unprecedented selectivity The specific aim of this project is to identify small molecule inhibitors of Renal Outer Medullary Potassium Channel -LRB- ROMK , Kir1 .1 , KCNJ1 -RRB- , a potassium channel located in the renal tubule , where it critically regulates sodium and potassium balance .
8861938	0	Potassium	131,140	ROMK	104,108	Potassium	ROMK	MESH:D011188	3758	Chemical	Gene	homeostasis|compound|START_ENTITY intracellular|dobj|homeostasis determines|xcomp|intracellular determines|dobj|sensitivity sensitivity|nmod|channels channels|appos|END_ENTITY	Identification of a titratable lysine residue that determines sensitivity of kidney potassium channels -LRB- ROMK -RRB- to intracellular pH. Potassium -LRB- K + -RRB- homeostasis is controlled by the secretion of K + ions across the apical membrane of renal collecting duct cells through a low-conductance inwardly rectifying K + channel .
26100633	0	Potassium	51,60	SLICK	69,74	Potassium	SLICK	MESH:D011188	304827(Tax:10116)	Chemical	Gene	promoter|compound|START_ENTITY promoter|compound|END_ENTITY	Transcriptional Regulation of the Sodium-activated Potassium Channel SLICK -LRB- KCNT2 -RRB- promoter by nuclear factor-kappa B. UNASSIGNED : Although recent studies have shown the sodium-activated potassium channel SLACK -LRB- KCNT1 -RRB- can contribute to neuronal excitability , there remains little information on the physiological role of the closely related SLICK -LRB- KCNT2 -RRB- channel .
25849724	0	Potassium	7,16	TASK-1	0,6	Potassium	TASK-1	MESH:D011188	16527(Tax:10090)	Chemical	Gene	Pancreatic|compound|START_ENTITY Pancreatic|compound|END_ENTITY	TASK-1 Potassium Channels Limit Pancreatic a-Cell Calcium Influx and Glucagon Secretion .
26268529	0	Potassium	45,54	TASK-3	38,44	Potassium	TASK-3	MESH:D011188	84429(Tax:10116)	Chemical	Gene	Function|compound|START_ENTITY Function|compound|END_ENTITY	Breathing Stimulant Compounds Inhibit TASK-3 Potassium Channel Function Likely by Binding at a Common Site in the Channel Pore .
25126877	0	Potassium	34,43	TREK-1	52,58	Potassium	TREK-1	MESH:D011188	16526(Tax:10090)	Chemical	Gene	Lung_Injury|compound|START_ENTITY Lung_Injury|compound|END_ENTITY	Deficiency of the Two-Pore-Domain Potassium Channel TREK-1 Promotes Hyperoxia-Induced Lung_Injury .
26869883	0	Potassium	44,53	TREK-1	20,26	Potassium	TREK-1	MESH:D011188	16526(Tax:10090)	Chemical	Gene	Channels|compound|START_ENTITY Alter|nsubj|Channels Deletion|parataxis|Alter Deletion|nmod|END_ENTITY	Genetic Deletion of TREK-1 or TWIK-1 / TREK-1 Potassium Channels does not Alter the Basic Electrophysiological Properties of Mature Hippocampal Astrocytes In Situ .
26869883	0	Potassium	44,53	TREK-1	37,43	Potassium	TREK-1	MESH:D011188	16526(Tax:10090)	Chemical	Gene	Channels|compound|START_ENTITY Channels|compound|END_ENTITY	Genetic Deletion of TREK-1 or TWIK-1 / TREK-1 Potassium Channels does not Alter the Basic Electrophysiological Properties of Mature Hippocampal Astrocytes In Situ .
26909044	0	Potassium	87,96	TREK-1	80,86	Potassium	TREK-1	MESH:D011188	16526(Tax:10090)	Chemical	Gene	Channel|compound|START_ENTITY Channel|compound|END_ENTITY	Fluoxetine Protection in Decompression Sickness in Mice is Enhanced by Blocking TREK-1 Potassium Channel with the `` spadin '' Antidepressant .
25886567	0	Potassium	24,33	TREK-2	131,137	Potassium	TREK-2	MESH:D011188	54207	Chemical	Gene	Channels|compound|START_ENTITY Up-Regulation|nmod|Channels Up-Regulation|dep|Relevance Relevance|nmod|Localization Localization|nmod|Channels Channels|compound|END_ENTITY	Up-Regulation of TREK-2 Potassium Channels in Cultured Astrocytes Requires De Novo Protein Synthesis : Relevance to Localization of TREK-2 Channels in Astrocytes after Transient Cerebral_Ischemia .
25886567	0	Potassium	24,33	TREK-2	17,23	Potassium	TREK-2	MESH:D011188	54207	Chemical	Gene	Channels|compound|START_ENTITY Channels|compound|END_ENTITY	Up-Regulation of TREK-2 Potassium Channels in Cultured Astrocytes Requires De Novo Protein Synthesis : Relevance to Localization of TREK-2 Channels in Astrocytes after Transient Cerebral_Ischemia .
27058598	0	Potassium	0,9	Trk1	29,33	Potassium	Trk1	MESH:D011188	853312(Tax:4932)	Chemical	Gene	Mediated|compound|START_ENTITY Mediated|nmod|END_ENTITY	Potassium Uptake Mediated by Trk1 Is Crucial for Candida_glabrata Growth and Fitness .
7768552	0	Potassium	0,9	angiotensin_II_type_1_receptor	31,61	Potassium	angiotensin II type 1 receptor	MESH:D011188	185	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Potassium negatively regulates angiotensin_II_type_1_receptor expression in human adrenocortical H295R cells .
8938715	0	Potassium	0,9	eag	55,58	Potassium	eag	MESH:D011188	32428(Tax:7227)	Chemical	Gene	currents|amod|START_ENTITY expressed|nsubj|currents expressed|nmod|cDNAs cDNAs|compound|END_ENTITY	Potassium currents expressed from Drosophila and mouse eag cDNAs in Xenopus oocytes .
26985309	0	Potassium	54,63	hERG	49,53	Potassium	hERG	MESH:D011188	2078	Chemical	Gene	Imaging|compound|START_ENTITY END_ENTITY|dobj|Imaging	Astemizole Derivatives as Fluorescent Probes for hERG Potassium Channel Imaging .
21833176	0	Potassium	40,49	hERG1	34,39	Potassium	hERG1	MESH:D011188	3757	Chemical	Gene	Channel|compound|START_ENTITY Channel|amod|END_ENTITY	Stereoselective Inhibition of the hERG1 Potassium Channel .
25809254	0	Potassium	84,93	hERG1	77,82	Potassium	hERG1	MESH:D011188	3757	Chemical	Gene	Channel|compound|START_ENTITY Channel|amod|.1 .1|dep|END_ENTITY	Kinetic Model for NS1643 Drug Activation of WT and L529I Variants of Kv11 .1 -LRB- hERG1 -RRB- Potassium Channel .
26339650	0	Potassium	6,15	hERG1	0,5	Potassium	hERG1	MESH:D011188	3757	Chemical	Gene	Channels|compound|START_ENTITY Channels|compound|END_ENTITY	hERG1 Potassium Channels : Novel Biomarkers in Human Solid Cancers .
1619503	0	Potassium	0,9	insulin	28,35	Potassium	insulin	MESH:D011188	3630	Chemical	Gene	START_ENTITY|nmod|link link|nmod|END_ENTITY	Potassium as a link between insulin and the renin-angiotensin-aldosterone system .
2065473	0	Potassium	0,9	insulin	20,27	Potassium	insulin	MESH:D011188	3630	Chemical	Gene	interrelationships|advmod|START_ENTITY interrelationships|nsubj|END_ENTITY	Potassium , glucose , insulin interrelationships during adrenaline infusion in normotensive and hypertensive_humans .
6124125	0	Potassium	0,9	insulin	57,64	Potassium	insulin	MESH:D011188	3630	Chemical	Gene	homeostasis|amod|START_ENTITY homeostasis|dep|effect effect|nmod|level level|compound|END_ENTITY	Potassium homeostasis during hyperinsulinemia : effect of insulin level , beta-blockade , and age .
7608319	0	Potassium	0,9	insulin	53,60	Potassium	insulin	MESH:D011188	3630	Chemical	Gene	modulation|amod|START_ENTITY modulation|dep|effect effect|nmod|pinacidil pinacidil|nmod|release release|compound|END_ENTITY	Potassium channel modulation : effect of pinacidil on insulin release in healthy volunteers .
19965868	0	Potassium	0,9	matrix_metalloprotease_23	50,75	Potassium	matrix metalloprotease 23	MESH:D011188	8510	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Potassium channel modulation by a toxin domain in matrix_metalloprotease_23 .
6313451	0	Potassium	0,9	parathyroid_hormone	21,40	Potassium	parathyroid hormone	MESH:D011188	280903(Tax:9913)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|amod|END_ENTITY	Potassium stimulates parathyroid_hormone release in the absence of extracellular calcium .
7084109	0	Potassium	0,9	parathyroid_hormone	21,40	Potassium	parathyroid hormone	MESH:D011188	280903(Tax:9913)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|amod|END_ENTITY	Potassium stimulates parathyroid_hormone release from perifused parathyroid cells .
10516122	0	Potassium	0,9	renin	32,37	Potassium	renin	MESH:D011188	24715(Tax:10116)	Chemical	Gene	control|amod|START_ENTITY control|nmod|secretion secretion|compound|END_ENTITY	Potassium control of extrarenal renin secretion in transgenic -LRB- mRen-2 -RRB- 27 and normal rats .
26893572	0	Potassium-3-beta-hydroxy-20-oxopregn-5-en-17-alpha-yl_sulfate	0,61	glucose-regulated_protein	91,116	Potassium-3-beta-hydroxy-20-oxopregn-5-en-17-alpha-yl sulfate	glucose-regulated protein	null	3309	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	Potassium-3-beta-hydroxy-20-oxopregn-5-en-17-alpha-yl_sulfate : a novel inhibitor of 78 kDa glucose-regulated_protein .
20414423	0	Potassium-Titanyl-Phosphate	56,83	Prostate-Specific_Antigen	17,42	Potassium-Titanyl-Phosphate	Prostate-Specific Antigen	MESH:C064806	354	Chemical	Gene	Levels|nmod|START_ENTITY Levels|compound|END_ENTITY	Changes in Serum Prostate-Specific_Antigen Levels after Potassium-Titanyl-Phosphate -LRB- KTP -RRB- Laser Vaporization of the Prostate .
25514384	0	Pramipexole	0,11	paraplegin	50,60	Pramipexole	paraplegin	MESH:C061333	6687	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|END_ENTITY	Pramipexole protects dopaminergic neurons through paraplegin against 6-hydroxydopamine .
12801316	0	Pranlukast	0,10	NF-kappa_B	20,30	Pranlukast	NF-kappa B	MESH:C047681	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	Pranlukast inhibits NF-kappa_B activation in human monocytes/macrophages and T cells .
10804983	0	Pranlukast	0,10	eosinophil_cationic_protein	62,89	Pranlukast	eosinophil cationic protein	MESH:C047681	6037	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|levels levels|compound|END_ENTITY	Pranlukast , a cysteinyl leukotriene antagonist , reduces serum eosinophil_cationic_protein levels in patients with asthma .
25012577	0	Prasugrel	0,9	P2Y12	90,95	Prasugrel	P2Y12	MESH:C408153	64805	Chemical	Gene	clopidogrel|compound|START_ENTITY overcomes|nsubj|clopidogrel overcomes|dobj|effect effect|nmod|inhibition inhibition|compound|END_ENTITY	Prasugrel but not high dose clopidogrel overcomes the lansoprazole neutralizing effect of P2Y12 inhibition : Results of the randomized DOSAPI study .
26119655	0	Prasugrel	64,73	P2Y12	46,51	Prasugrel	P2Y12	MESH:C408153	64805	Chemical	Gene	Meta-Analysis|appos|START_ENTITY Meta-Analysis|nmod|Comparison Comparison|nmod|Inhibitors Inhibitors|compound|END_ENTITY	Meta-Analysis of Comparison of the Newer Oral P2Y12 Inhibitors -LRB- Prasugrel or Ticagrelor -RRB- to Clopidogrel in Patients With Non-ST-Elevation Acute Coronary_Syndrome .
27053057	0	Prasugrel	0,9	P2Y12	22,27	Prasugrel	P2Y12	MESH:C408153	70839(Tax:10090)	Chemical	Gene	START_ENTITY|appos|Antagonist Antagonist|compound|END_ENTITY	Prasugrel , a Platelet P2Y12 Receptor Antagonist , Improves Abnormal Gait in a Novel Murine Model of Thrombotic_Hindlimb_Ischemia .
20157364	0	Pravastatin	85,96	C-reactive_Protein	11,29	Pravastatin	C-reactive Protein	MESH:D017035	1401	Chemical	Gene	Modulation|nmod|START_ENTITY Effects|dep|Modulation Effects|nmod|END_ENTITY	Effects of C-reactive_Protein and Homocysteine on Cytokine Production : Modulation by Pravastatin .
17283264	0	Pravastatin	115,126	C-reactive_protein	0,18	Pravastatin	C-reactive protein	MESH:D017035	1401	Chemical	Gene	Study|nmod|START_ENTITY END_ENTITY|nmod|Study	C-reactive_protein and prediction of coronary_heart_disease and global vascular events in the Prospective Study of Pravastatin in the Elderly at Risk -LRB- PROSPER -RRB- .
22089528	0	Pravastatin	0,11	C-reactive_protein	21,39	Pravastatin	C-reactive protein	MESH:D017035	25419(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|generation generation|amod|END_ENTITY	Pravastatin inhibits C-reactive_protein generation induced by fibrinogen , fibrin and FDP in isolated rat vascular smooth muscle cells .
1645956	0	Pravastatin	0,11	HMG-CoA_reductase	15,32	Pravastatin	HMG-CoA reductase	MESH:D017035	25675(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Pravastatin , a HMG-CoA_reductase inhibitor , blocks the cell cycle progression but not Ca2 + influx induced by IGF-I in FRTL-5 cells .
18632424	0	Pravastatin	0,11	IL-6	28,32	Pravastatin	IL-6	MESH:D017035	3569	Chemical	Gene	immunomodulates|nsubj|START_ENTITY immunomodulates|xcomp|END_ENTITY	Pravastatin immunomodulates IL-6 and C-reactive_protein , but not IL-1 and TNF-alpha , in cardio-pulmonary bypass .
19330073	0	Pravastatin	0,11	IL-6	152,156	Pravastatin	IL-6	MESH:D017035	16193(Tax:10090)	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|dobj|aortic_atherosclerosis aortic_atherosclerosis|nmod|modulation modulation|nmod|signal_transduction_and_activation_of_transcription_3 signal_transduction_and_activation_of_transcription_3|acl|attenuate attenuate|dobj|action action|appos|END_ENTITY	Pravastatin prevents aortic_atherosclerosis via modulation of signal_transduction_and_activation_of_transcription_3 -LRB- STAT3 -RRB- to attenuate interleukin-6 -LRB- IL-6 -RRB- action in ApoE knockout mice .
27034587	0	Pravastatin	22,33	IL-6	56,60	Pravastatin	IL-6	MESH:D017035	3569	Chemical	Gene	START_ENTITY|nmod|Production Production|compound|END_ENTITY	Klotho Contributes to Pravastatin Effect on Suppressing IL-6 Production in Endothelial Cells .
27034587	0	Pravastatin	22,33	Klotho	0,6	Pravastatin	Klotho	MESH:D017035	9365	Chemical	Gene	Contributes|xcomp|START_ENTITY Contributes|nsubj|END_ENTITY	Klotho Contributes to Pravastatin Effect on Suppressing IL-6 Production in Endothelial Cells .
16373606	0	Pravastatin	0,11	LOX-1	92,97	Pravastatin	LOX-1	MESH:D017035	100009322(Tax:9986)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Pravastatin inhibits expression of lectin-like_oxidized_low-density_lipoprotein_receptor-1 -LRB- LOX-1 -RRB- in Watanabe_heritable_hyperlipidemic rabbits : a new pleiotropic effect of statins .
17112529	0	Pravastatin	0,11	adiponectin	74,85	Pravastatin	adiponectin	MESH:D017035	9370	Chemical	Gene	improved|nsubj|START_ENTITY improved|dobj|metabolism metabolism|acl|associated associated|advcl|increasing increasing|dobj|END_ENTITY	Pravastatin improved glucose metabolism associated with increasing plasma adiponectin in patients with impaired_glucose_tolerance and coronary_artery_disease .
20702974	0	Pravastatin	0,11	adiponectin	43,54	Pravastatin	adiponectin	MESH:D017035	9370	Chemical	Gene	potentiates|compound|START_ENTITY increases|nsubj|potentiates increases|advcl|receiving receiving|nsubj|concentration concentration|compound|END_ENTITY	Pravastatin potentiates increases in serum adiponectin concentration in dyslipidemic patients receiving thiazolidinedione : the DOLPHIN study .
20102908	0	Pravastatin	100,111	apolipoprotein_A-I	39,57	Pravastatin	apolipoprotein A-I	MESH:D017035	335	Chemical	Gene	treatment|compound|START_ENTITY regression|nmod|treatment ratio|nmod|regression ratio|compound|END_ENTITY	Relation of change in apolipoprotein_B / apolipoprotein_A-I ratio to coronary plaque regression after Pravastatin treatment in patients with coronary_artery_disease .
11606315	0	Pravastatin	0,11	interleukin-8	27,40	Pravastatin	interleukin-8	MESH:D017035	3576	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|production production|amod|END_ENTITY	Pravastatin suppresses the interleukin-8 production induced by thrombin in human aortic endothelial cells cultured with high glucose by inhibiting the p44/42 mitogen activated protein kinase .
17347584	0	Pravastatin	0,11	monocyte_chemoattractant_protein_1	49,83	Pravastatin	monocyte chemoattractant protein 1	MESH:D017035	20296(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Pravastatin inhibits carboxymethyllysine-induced monocyte_chemoattractant_protein_1 expression in podocytes via prevention of signalling events .
10397612	0	Pravastatin	0,11	organic_anion_transporting_polypeptide	67,105	Pravastatin	organic anion transporting polypeptide	MESH:D017035	170698(Tax:10116)	Chemical	Gene	transported|nsubjpass|START_ENTITY transported|nmod|END_ENTITY	Pravastatin , an HMG-CoA reductase inhibitor , is transported by rat organic_anion_transporting_polypeptide , oatp2 .
21187414	0	Pravastatin	0,11	placental_growth_factor	20,43	Pravastatin	placental growth factor	MESH:D017035	18654(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Pravastatin induces placental_growth_factor -LRB- PGF -RRB- and ameliorates_preeclampsia in a mouse model .
17211835	0	Pravastatin	0,11	thrombomodulin	20,34	Pravastatin	thrombomodulin	MESH:D017035	7056	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Pravastatin induces thrombomodulin expression in TNFalpha-treated human aortic endothelial cells by inhibiting Rac1 and Cdc42 translocation and activity .
1926908	0	Pravastatin_sodium	0,18	HMG-CoA_reductase	26,43	Pravastatin sodium	HMG-CoA reductase	MESH:D017035	3156	Chemical	Gene	inhibitor|advmod|START_ENTITY inhibitor|nsubj|END_ENTITY	Pravastatin_sodium , a new HMG-CoA_reductase inhibitor .
16518329	0	Prednisolone	0,12	MCP-1	60,65	Prednisolone	MCP-1	MESH:D011239	6347	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Prednisolone inhibits hyperosmolarity-induced expression of MCP-1 via NF-kappaB in peritoneal mesothelial cells .
12365719	0	Prednisolone	0,12	interleukin-18	21,35	Prednisolone	interleukin-18	MESH:D011239	3606	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Prednisolone induces interleukin-18 expression in mononuclear blood and myeloid progenitor cells .
25319133	0	Prednisone	0,10	COX-2	52,57	Prednisone	COX-2	MESH:D011241	17709(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Prednisone inhibits the IL-1b-induced expression of COX-2 in HEI-OC1 murine auditory cells through the inhibition of ERK-1 / 2 , JNK-1 and AP-1 activity .
9001335	0	Prednisone	0,10	PGH-synthase_2	21,35	Prednisone	PGH-synthase 2	MESH:D011241	5743	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Prednisone increases PGH-synthase_2 in atopic humans in vivo .
22451918	0	Prefoldin	18,27	Mgr	11,14	Prefoldin	Mgr	null	41365(Tax:7227)	Chemical	Gene	subunit|amod|START_ENTITY END_ENTITY|appos|subunit	Drosophila Mgr , a Prefoldin subunit cooperating with von_Hippel_Lindau to regulate tubulin stability .
3325129	0	Pregnanolone	0,12	LH-RH	55,60	Pregnanolone	LH-RH	MESH:D011280	25194(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|amod|END_ENTITY	Pregnanolone , a metabolite of progesterone , stimulates LH-RH release : in vitro and in vivo studies .
6653650	0	Prenalterol	0,11	beta-1_adrenoceptor	21,40	Prenalterol	beta-1 adrenoceptor	MESH:D011294	153	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Prenalterol , an oral beta-1_adrenoceptor agonist , in the treatment of chronic_heart_failure .
2859252	0	Prenalterol	0,11	beta_1-adrenoceptor	23,42	Prenalterol	beta 1-adrenoceptor	MESH:D011294	153	Chemical	Gene	START_ENTITY|dep|agonist agonist|amod|END_ENTITY	Prenalterol : a partial beta_1-adrenoceptor agonist or a beta-blocker with intrinsic activity ?
10841772	0	Prenyl-flavonoids	0,17	Pdr5p	46,51	Prenyl-flavonoids	Pdr5p	null	854324(Tax:4932)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Prenyl-flavonoids as potent inhibitors of the Pdr5p multidrug ABC transporter from Saccharomyces_cerevisiae .
26449282	0	Prenylated_Flavonoids	87,108	Estrogen_Receptor	140,157	Prenylated Flavonoids	Estrogen Receptor	null	2099	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of a Hydrophobic Pocket and Helix 11 in Determining the Modes of Action of Prenylated_Flavonoids and Isoflavonoids in the Human Estrogen_Receptor .
24957686	0	Pristimerin	0,11	TNF-a	69,74	Pristimerin	TNF-a	MESH:C009043	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Pristimerin , a natural anti-tumor triterpenoid , inhibits LPS-induced TNF-a and IL-8 production through down-regulation of ROS-related classical NF-kB pathway in THP-1 cells .
26284090	0	Pro	43,46	ProDH	63,68	Pro	ProDH	CHEBI:32866	822833(Tax:3702)	Chemical	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	P5CDH affects the pathways contributing to Pro synthesis after ProDH activation by biotic and abiotic stress conditions .
26284090	0	Pro	43,46	ProDH	63,68	Pro	ProDH	CHEBI:32866	822833(Tax:3702)	Chemical	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	P5CDH affects the pathways contributing to Pro synthesis after ProDH activation by biotic and abiotic stress conditions .
22772900	0	Pro-Gly-Pro	44,55	VEGF	77,81	Pro-Gly-Pro	VEGF	MESH:C113164	83785(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|genes genes|amod|END_ENTITY	Effect of semax and its C-terminal fragment Pro-Gly-Pro on the expression of VEGF family genes and their receptors in experimental focal ischemia of the rat brain .
24591641	0	Pro-Gly-Pro	11,22	aminopeptidase	70,84	Pro-Gly-Pro	aminopeptidase	MESH:C113164	10404	Chemical	Gene	Binding|nmod|START_ENTITY Binding|dep|END_ENTITY	Binding of Pro-Gly-Pro at the active site of leukotriene_A4_hydrolase / aminopeptidase and development of an epoxide hydrolase selective inhibitor .
16818	0	Pro-Leu-Gly-NH2	73,88	ACTH	15,19	Pro-Leu-Gly-NH2	ACTH	MESH:D009075	5443	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Suppression Suppression|nmod|END_ENTITY	Suppression of ACTH secretion by synthetic MSH-release_inhibiting_factor Pro-Leu-Gly-NH2 in Addison 's _ disease .
11033990	0	Pro12Ala	0,8	PPARgamma2	76,86	Pro12Ala	PPARgamma2	null	5468	Chemical	Gene	mutation|amod|START_ENTITY mutation|nmod|END_ENTITY	Pro12Ala mutation in the peroxisome_proliferator-activated_receptor_gamma2 -LRB- PPARgamma2 -RRB- and severe obesity : a case-control study .
12765972	0	Pro12Ala	0,8	peroxisome_proliferator-activated_receptor-gamma2	16,65	Pro12Ala	peroxisome proliferator-activated receptor-gamma2	null	5468	Chemical	Gene	START_ENTITY|nmod|gene gene|amod|END_ENTITY	Pro12Ala of the peroxisome_proliferator-activated_receptor-gamma2 gene is associated with lower serum insulin levels in nonobese African Americans : the Atherosclerosis Risk in Communities Study .
20626034	0	Proanthocyanidins	0,17	matrix_metalloproteinase-2_and_matrix_metalloproteinase-9	78,135	Proanthocyanidins	matrix metalloproteinase-2 and matrix metalloproteinase-9	MESH:D044945	4313;4318	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|activity activity|amod|END_ENTITY	Proanthocyanidins from the American Cranberry -LRB- Vaccinium macrocarpon -RRB- inhibit matrix_metalloproteinase-2_and_matrix_metalloproteinase-9 activity in human prostate_cancer cells via alterations in multiple cellular signalling pathways .
26028544	0	Proaporphine	0,12	acetylcholinesterase	42,62	Proaporphine	acetylcholinesterase	null	43	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Proaporphine and aporphine_alkaloids with acetylcholinesterase inhibitory activity from Stephania epigaea .
21629661	0	Probenecid	0,10	TAS2R16	52,59	Probenecid	TAS2R16	MESH:D011339	50833	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Probenecid inhibits the human bitter taste receptor TAS2R16 and suppresses bitter perception of salicin .
26007302	0	Probenecid	25,35	carbonic_anhydrase_IX_and_XII	63,92	Probenecid	carbonic anhydrase IX and XII	MESH:D011339	768	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	New amide derivatives of Probenecid as selective inhibitors of carbonic_anhydrase_IX_and_XII : Biological evaluation and molecular modelling studies .
26007302	0	Probenecid	25,35	carbonic_anhydrase_IX_and_XII	63,92	Probenecid	carbonic anhydrase IX and XII	MESH:D011339	768	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	New amide derivatives of Probenecid as selective inhibitors of carbonic_anhydrase_IX_and_XII : Biological evaluation and molecular modelling studies .
18596212	0	Probenecid	0,10	pannexin_1	36,46	Probenecid	pannexin 1	MESH:D011339	24145	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|channels channels|amod|END_ENTITY	Probenecid , a gout remedy , inhibits pannexin_1 channels .
1968900	0	Probestin	0,9	aminopeptidase_M	30,46	Probestin	aminopeptidase M	MESH:C063432	290	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Probestin , a new inhibitor of aminopeptidase_M , produced by Streptomyces azureus MH663-2F6 .
1968901	0	Probestin	0,9	aminopeptidase_M	30,46	Probestin	aminopeptidase M	MESH:C063432	290	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Probestin , a new inhibitor of aminopeptidase_M , produced by Streptomyces azureus MH663-2F6 .
8696945	0	Probucol	0,8	E-selectin	23,33	Probucol	E-selectin	MESH:D011341	6401	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	Probucol downregulates E-selectin expression on cultured human vascular endothelial cells .
15043509	0	Probucol	0,8	HERG	106,110	Probucol	HERG	MESH:D011341	3757	Chemical	Gene	aggravates|nsubj|START_ENTITY aggravates|dobj|long_QT_syndrome long_QT_syndrome|acl|associated associated|nmod|M124T M124T|nmod|N-terminus N-terminus|nmod|END_ENTITY	Probucol aggravates long_QT_syndrome associated with a novel missense mutation M124T in the N-terminus of HERG .
10412767	0	Probucol	0,8	ICAM-1	20,26	Probucol	ICAM-1	MESH:D011341	25464(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Probucol suppresses ICAM-1 expression in rat mesangial cells : possible role of IL-1 .
26897284	0	Probucol	0,8	MMP-9	18,23	Probucol	MMP-9	MESH:D011341	17395(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Probucol inhibits MMP-9 expression through regulating miR-497 in HUVECs and apoE knockout mice .
24594116	0	Probucol	0,8	NHE1	27,31	Probucol	NHE1	MESH:D011341	20544(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Probucol via inhibition of NHE1 attenuates LPS-accelerated atherosclerosis and promotes plaque stability in vivo .
24432375	0	Probucol	0,8	Nox2	19,23	Probucol	Nox2	MESH:D011341	13058(Tax:10090)	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|dobj|expression expression|amod|END_ENTITY	Probucol inhibited Nox2 expression and attenuated podocyte injury in type 2 diabetic_nephropathy of db/db mice .
1936105	0	Probucol	0,8	cholesteryl_ester_transfer_protein	19,53	Probucol	cholesteryl ester transfer protein	MESH:D011341	1071	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|activity activity|compound|END_ENTITY	Probucol increases cholesteryl_ester_transfer_protein activity in hypercholesterolaemic patients .
16424789	0	Probucol	0,8	paraoxonase_1	22,35	Probucol	paraoxonase 1	MESH:D011341	100009133(Tax:9986)	Chemical	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|amod|END_ENTITY	Probucol up-regulates paraoxonase_1 expression in hepatocytes of hypercholesterolemic rabbits .
16230360	0	Procainamide	0,12	DNA_methyltransferase_1	40,63	Procainamide	DNA methyltransferase 1	MESH:D011342	1786	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Procainamide is a specific inhibitor of DNA_methyltransferase_1 .
833415	0	Procaine_hydrochloride	0,22	monoamine_oxidase	28,45	Procaine hydrochloride	monoamine oxidase	MESH:D011343	29253(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|amod|END_ENTITY	Procaine_hydrochloride as a monoamine_oxidase inhibitor : implications for Geriatric therapy .
10686961	0	Procalcitonin	1,14	C-reactive_protein	57,75	Procalcitonin	C-reactive protein	MESH:C029100	1401	Chemical	Gene	START_ENTITY|dep|comparison comparison|nmod|alpha alpha|amod|END_ENTITY	-LSB- Procalcitonin in pediatric emergencies : comparison with C-reactive_protein , interleukin-6 and interferon alpha in the differentiation between bacterial and viral_infections -RSB- .
10804941	0	Procalcitonin	0,13	C-reactive_protein	30,48	Procalcitonin	C-reactive protein	MESH:C029100	1401	Chemical	Gene	correlates|nsubj|START_ENTITY correlates|nmod|END_ENTITY	Procalcitonin correlates with C-reactive_protein as an acute-phase reactant in pediatric patients .
11167745	0	Procalcitonin	0,13	C-reactive_protein	93,111	Procalcitonin	C-reactive protein	MESH:C029100	1401	Chemical	Gene	START_ENTITY|parataxis|superior superior|nmod|that that|nmod|receptor receptor|amod|END_ENTITY	Procalcitonin in paediatric cancer patients : its diagnostic relevance is superior to that of C-reactive_protein , interleukin_6 , interleukin_8 , soluble interleukin 2 receptor and soluble tumour necrosis factor receptor II .
16038389	0	Procalcitonin	0,13	C-reactive_protein	32,50	Procalcitonin	C-reactive protein	MESH:C029100	1401	Chemical	Gene	useful|nsubj|START_ENTITY useful|advcl|predict predict|nsubj|END_ENTITY	Procalcitonin is useful whereas C-reactive_protein is not , to predict complications following coronary artery bypass surgery .
17536601	0	Procalcitonin	0,13	C-reactive_protein	88,106	Procalcitonin	C-reactive protein	MESH:C029100	1401	Chemical	Gene	START_ENTITY|dep|correlation correlation|nmod|END_ENTITY	Procalcitonin in patients with acute_coronary_syndrome : correlation with high-sensitive C-reactive_protein , prognosis and severity of coronary_artery_disease .
19057447	0	Procalcitonin	0,13	C-reactive_protein	21,39	Procalcitonin	C-reactive protein	MESH:C029100	1401	Chemical	Gene	versus|nsubj|START_ENTITY versus|dobj|ratio ratio|amod|END_ENTITY	Procalcitonin versus C-reactive_protein and immature-to-total neutrophil ratio as markers of infection after cardiopulmonary bypass in children .
20576731	0	Procalcitonin	0,13	C-reactive_protein	17,35	Procalcitonin	C-reactive protein	MESH:C029100	1401	Chemical	Gene	vs|nsubj|START_ENTITY vs|xcomp|END_ENTITY	Procalcitonin vs C-reactive_protein as predictive markers of response to antibiotic therapy in acute exacerbations of COPD .
22367384	0	Procalcitonin	0,13	C-reactive_protein	34,52	Procalcitonin	C-reactive protein	MESH:C029100	1401	Chemical	Gene	useful|nsubj|START_ENTITY useful|nmod|END_ENTITY	Procalcitonin is more useful than C-reactive_protein in differentiation of fever in patients with sickle_cell_disease .
22764546	0	Procalcitonin	0,13	C-reactive_protein	37,55	Procalcitonin	C-reactive protein	MESH:C029100	1401	Chemical	Gene	score|nsubj|START_ENTITY score|nmod|score score|compound|END_ENTITY	Procalcitonin and BISAP score versus C-reactive_protein and APACHE II score in early assessment of severity and outcome of acute_pancreatitis .
24455636	0	Procalcitonin	0,13	C-reactive_protein	31,49	Procalcitonin	C-reactive protein	MESH:C029100	1401	Chemical	Gene	role|compound|START_ENTITY role|compound|END_ENTITY	Procalcitonin and quantitative C-reactive_protein role in the early diagnosis of sepsis in patients with febrile_neutropenia .
25195647	0	Procalcitonin	0,13	C-reactive_protein	26,44	Procalcitonin	C-reactive protein	MESH:C029100	1401	Chemical	Gene	count|nsubj|START_ENTITY count|advmod|better better|nmod|END_ENTITY	Procalcitonin better than C-reactive_protein , erythrocyte sedimentation rate , and white blood cell count in predicting DNAemia in patients with sepsis .
11546966	0	Procalcitonin	0,13	interleukin-6	21,34	Procalcitonin	interleukin-6	MESH:C029100	3569	Chemical	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	Procalcitonin versus interleukin-6 levels in bronchoalveolar lavage fluids of trauma victims with severe lung_contusion .
11167745	0	Procalcitonin	0,13	interleukin_6	113,126	Procalcitonin	interleukin 6	MESH:C029100	3569	Chemical	Gene	START_ENTITY|parataxis|superior superior|nmod|that that|nmod|receptor receptor|amod|END_ENTITY	Procalcitonin in paediatric cancer patients : its diagnostic relevance is superior to that of C-reactive_protein , interleukin_6 , interleukin_8 , soluble interleukin 2 receptor and soluble tumour necrosis factor receptor II .
11167745	0	Procalcitonin	0,13	interleukin_8	128,141	Procalcitonin	interleukin 8	MESH:C029100	3576	Chemical	Gene	START_ENTITY|parataxis|superior superior|nmod|that that|nmod|receptor receptor|amod|END_ENTITY	Procalcitonin in paediatric cancer patients : its diagnostic relevance is superior to that of C-reactive_protein , interleukin_6 , interleukin_8 , soluble interleukin 2 receptor and soluble tumour necrosis factor receptor II .
10573218	0	Procaterol	0,10	IL-1beta	20,28	Procaterol	IL-1beta	MESH:D017265	3553	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Procaterol inhibits IL-1beta - and TNF-alpha-mediated epithelial cell eosinophil chemotactic activity .
16772725	0	Procaterol	0,10	peroxisome_proliferator-activated_receptor-gamma	23,71	Procaterol	peroxisome proliferator-activated receptor-gamma	MESH:D017265	5468	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Procaterol upregulates peroxisome_proliferator-activated_receptor-gamma expression in human eosinophils .
24471892	0	Procyanidin	0,11	c-Jun	87,92	Procyanidin	c-Jun	MESH:C017674	3725	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|apoptosis apoptosis|nmod|cells cells|nmod|activation activation|nmod|END_ENTITY	Procyanidin induces apoptosis of esophageal_adenocarcinoma cells via JNK activation of c-Jun .
27057282	0	Procyanidin_B2	115,129	FoxO1	17,22	Procyanidin B2	FoxO1	MESH:C479580	2308	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Critical Role of FoxO1 in Granulosa Cell Apoptosis Caused by Oxidative Stress and Protective Effects of Grape Seed Procyanidin_B2 .
25379992	0	Procyanidin_B2	0,14	IL-1b	46,51	Procyanidin B2	IL-1b	MESH:C479580	3553	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	Procyanidin_B2 inhibits inflammasome-mediated IL-1b production in lipopolysaccharide-stimulated macrophages .
17237295	0	Prodigiosin	0,11	NAG-1	42,47	Prodigiosin	NAG-1	MESH:D011353	9518	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Prodigiosin induces the proapoptotic gene NAG-1 via glycogen_synthase_kinase-3beta activity in human breast_cancer cells .
22372491	0	Prodigiosin	0,11	SKP2	27,31	Prodigiosin	SKP2	MESH:D011353	6502	Chemical	Gene	down-regulates|compound|START_ENTITY END_ENTITY|nsubj|down-regulates	Prodigiosin down-regulates SKP2 to induce p27 -LRB- KIP1 -RRB- stabilization and antiproliferation in human lung_adenocarcinoma cells .
18378698	0	Progesterone	0,12	11beta-hydroxysteroid_dehydrogenase_type_2	30,72	Progesterone	11beta-hydroxysteroid dehydrogenase type 2	MESH:D011374	3291	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|promoter promoter|amod|END_ENTITY	Progesterone induction of the 11beta-hydroxysteroid_dehydrogenase_type_2 promoter in breast_cancer cells involves coordinated recruitment of STAT5A and progesterone_receptor to a distal enhancer and polymerase tracking .
10999824	0	Progesterone	0,12	17beta-hydroxysteroid_dehydrogenase_type_2	26,68	Progesterone	17beta-hydroxysteroid dehydrogenase type 2	MESH:D011374	3294	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Progesterone induction of 17beta-hydroxysteroid_dehydrogenase_type_2 during the secretory phase occurs in the endometrium of estrogen-dependent benign diseases but not in normal endometrium .
9322971	0	Progesterone	0,12	20alpha-hydroxysteroid_dehydrogenase	22,58	Progesterone	20alpha-hydroxysteroid dehydrogenase	MESH:D011374	171516(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Progesterone inhibits 20alpha-hydroxysteroid_dehydrogenase expression in the rat corpus luteum through the glucocorticoid receptor .
26302112	0	Progesterone	32,44	ALK3	60,64	Progesterone	ALK3	MESH:D011374	657	Chemical	Gene	Production|compound|START_ENTITY Production|nmod|END_ENTITY	BMP4 and BMP7 Suppress StAR and Progesterone Production via ALK3 and SMAD1/5/8-SMAD 4 in Human Granulosa-Lutein Cells .
16445913	0	Progesterone	0,12	AQP4	38,42	Progesterone	AQP4	MESH:D011374	25293(Tax:10116)	Chemical	Gene	modulates|amod|START_ENTITY END_ENTITY|nsubj|modulates	Progesterone administration modulates AQP4 expression and edema after traumatic_brain_injury in male rats .
24174577	0	Progesterone	0,12	AVEN	27,31	Progesterone	AVEN	MESH:D011374	512666(Tax:9913)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Progesterone regulation of AVEN protects bovine oocytes from apoptosis during meiotic maturation .
26818151	0	Progesterone	0,12	Akt	97,100	Progesterone	Akt	MESH:D011374	24185(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	Progesterone modulates endothelial progenitor cell -LRB- EPC -RRB- viability through the CXCL12/CXCR4/PI3K / Akt signalling pathway .
23988382	0	Progesterone	0,12	BCRP	34,38	Progesterone	BCRP	MESH:D011374	9429	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Progesterone negatively regulates BCRP in progesterone_receptor-positive human breast_cancer cells .
21760855	0	Progesterone	0,12	BIRC3	37,42	Progesterone	BIRC3	MESH:D011374	330	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Progesterone receptor-B induction of BIRC3 protects endometrial_cancer cells from AP1-59-mediated apoptosis .
3471532	0	Progesterone	0,12	CA-125	29,35	Progesterone	CA-125	MESH:D011374	94025	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Progesterone increases serum CA-125 in endometriosis .
23226939	0	Progesterone	0,12	CFTR	59,63	Progesterone	CFTR	MESH:D011374	24255(Tax:10116)	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|nmod|proteins proteins|compound|END_ENTITY	Progesterone downregulates oestrogen-induced expression of CFTR and SLC26A6 proteins and mRNA in rats ' uteri .
17468394	0	Progesterone	0,12	CXCL12	100,106	Progesterone	CXCL12	MESH:D011374	24772(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	Progesterone reduces the migration of mast cells toward the chemokine stromal cell-derived factor-1 / CXCL12 with an accompanying decrease in CXCR4 receptors .
23996076	0	Progesterone	0,12	E-cadherin	54,64	Progesterone	E-cadherin	MESH:D011374	999	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|levels levels|nmod|END_ENTITY	Progesterone decreases levels of the adhesion protein E-cadherin and promotes invasiveness of steroid receptor positive breast_cancers .
7891165	0	Progesterone	0,12	Fos	55,58	Progesterone	Fos	MESH:D011374	314322(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|increase increase|nmod|END_ENTITY	Progesterone enhances an estradiol-induced increase in Fos immunoreactivity in localized regions of female rat forebrain .
23493386	0	Progesterone	15,27	Glial_Cell_Line-derived_Neurotrophic_Factor	31,74	Progesterone	Glial Cell Line-derived Neurotrophic Factor	MESH:D011374	25453(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|Secretion Secretion|compound|END_ENTITY	The Effects of Progesterone on Glial_Cell_Line-derived_Neurotrophic_Factor Secretion from C6 Glioma Cells .
16726114	0	Progesterone	0,12	GnRH	130,134	Progesterone	GnRH	MESH:D011374	2796	Chemical	Gene	secretion|amod|START_ENTITY bitches|nsubj|secretion bitches|nmod|administration administration|nmod|gonadotropin-releasing_hormone gonadotropin-releasing_hormone|appos|END_ENTITY	Progesterone secretion by induced corpora lutea -LRB- CL -RRB- of anestrous bitches after administration of gonadotropin-releasing_hormone -LRB- GnRH -RRB- and human chorionic gonadotropin -LRB- HOG -RRB- .
20501305	0	Progesterone	0,12	GnRH	37,41	Progesterone	GnRH	MESH:D011374	25194(Tax:10116)	Chemical	Gene	stimulation|amod|START_ENTITY stimulation|nmod|release release|compound|END_ENTITY	Progesterone stimulation of in vitro GnRH release from the hypothalamus of the estrogen-primed , ovariectomized rat : serotoninergic role .
20739401	0	Progesterone	0,12	GnRH	150,154	Progesterone	GnRH	MESH:D011374	14714(Tax:10090)	Chemical	Gene	inhibits|amod|START_ENTITY potentiates|nsubj|inhibits potentiates|dobj|currents currents|nmod|neurons neurons|appos|END_ENTITY	Progesterone treatment inhibits and dihydrotestosterone -LRB- DHT -RRB- treatment potentiates voltage-gated calcium currents in gonadotropin-releasing_hormone -LRB- GnRH -RRB- neurons .
21273126	0	Progesterone	0,12	GnRH	32,36	Progesterone	GnRH	MESH:D011374	2796	Chemical	Gene	rise|amod|START_ENTITY rise|nmod|day day|nmod|cycles cycles|compound|END_ENTITY	Progesterone rise on HCG day in GnRH antagonist/rFSH stimulated cycles affects endometrial gene expression .
6339857	0	Progesterone	0,12	GnRH	80,84	Progesterone	GnRH	MESH:D011374	25194(Tax:10116)	Chemical	Gene	stimulate|nsubj|START_ENTITY stimulate|dobj|release release|nmod|END_ENTITY	Progesterone and 20 alpha-hydroxyprogesterone stimulate the in vitro release of GnRH by the isolated mediobasal hypothalamus .
7953720	0	Progesterone	0,12	GnRH	24,28	Progesterone	GnRH	MESH:D011374	25194(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Progesterone stimulates GnRH gene expression in the hypothalamus of ovariectomized , estrogen treated adult rats .
25710617	0	Progesterone	90,102	Gonadotropin-Releasing_Hormone	0,30	Progesterone	Gonadotropin-Releasing Hormone	MESH:D011374	2796	Chemical	Gene	Dermatitis|compound|START_ENTITY Use|nmod|Dermatitis Use|compound|END_ENTITY	Gonadotropin-Releasing_Hormone Agonist Use to Guide Diagnosis and Treatment of Autoimmune Progesterone Dermatitis .
16210391	0	Progesterone	0,12	HLA-G	22,27	Progesterone	HLA-G	MESH:D011374	3135	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Progesterone enhances HLA-G gene expression in JEG-3 choriocarcinoma cells and human cytotrophoblasts in vitro .
16684846	0	Progesterone	0,12	HLA-G	23,28	Progesterone	HLA-G	MESH:D011374	3135	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Progesterone regulates HLA-G gene expression through a novel progesterone response element .
25897495	0	Progesterone	35,47	Hand2	121,126	Progesterone	Hand2	MESH:D011374	64637(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|Regulation Regulation|nmod|END_ENTITY	A Suppressive Antagonism Evidences Progesterone and Estrogen Receptor Pathway Interaction with Concomitant Regulation of Hand2 , Bmp2 and ERK during Early Decidualization .
11376858	0	Progesterone	0,12	Krox-20	24,31	Progesterone	Krox-20	MESH:D011374	114090(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	Progesterone stimulates Krox-20 gene expression in Schwann cells .
17478888	0	Progesterone	0,12	Krox-20	48,55	Progesterone	Krox-20	MESH:D011374	114090(Tax:10116)	Chemical	Gene	derivatives|amod|START_ENTITY increase|nsubj|derivatives increase|dobj|expression expression|nmod|END_ENTITY	Progesterone derivatives increase expression of Krox-20 and Sox-10 in rat Schwann cells .
2693878	0	Progesterone	0,12	LHRH	105,109	Progesterone	LHRH	MESH:D011374	25194(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dep|encoding encoding|dobj|level level|appos|END_ENTITY	Progesterone increases messenger ribonucleic acid -LRB- mRNA -RRB- encoding luteinizing_hormone_releasing_hormone -LRB- LHRH -RRB- level in the hypothalamus of ovariectomized estradiol-primed prepubertal rats .
24140060	0	Progesterone	0,12	Lrp2	35,39	Progesterone	Lrp2	MESH:D011374	14725(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Progesterone induces expression of Lrp2 in the murine uterus .
26188381	0	Progesterone	0,12	MCP-1	86,91	Progesterone	MCP-1	MESH:D011374	24770(Tax:10116)	Chemical	Gene	protects|nsubj|START_ENTITY protects|advcl|decreasing decreasing|dobj|infiltration infiltration|amod|END_ENTITY	Progesterone protects endothelial cells after cerebrovascular_occlusion by decreasing MCP-1 - and CXCL1-mediated macrophage infiltration .
26280733	0	Progesterone	0,12	MKP-1	73,78	Progesterone	MKP-1	MESH:D011374	1843	Chemical	Gene	START_ENTITY|dep|Roles Roles|nmod|END_ENTITY	Progesterone and the Repression of Myometrial Inflammation : The Roles of MKP-1 and the AP-1 System .
24567055	0	Progesterone	0,12	Nogo-A	20,26	Progesterone	Nogo-A	MESH:D011374	83765(Tax:10116)	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|expression expression|compound|END_ENTITY	Progesterone alters Nogo-A , GFAP and GAP-43 expression in a rat model of traumatic_brain_injury .
2562956	0	Progesterone	0,12	P-glycoprotein	28,42	Progesterone	P-glycoprotein	MESH:D011374	67078(Tax:10090)	Chemical	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Progesterone interacts with P-glycoprotein in multidrug-resistant cells and in the endometrium of gravid uterus .
20101845	0	Progesterone	63,75	Part_1	55,61	Progesterone	Part 1	MESH:D011374	25859	Chemical	Gene	therapy|amod|START_ENTITY END_ENTITY|dep|therapy	A practical approach to the prevention of miscarriage : Part_1 -- Progesterone therapy .
24401475	0	Progesterone	85,97	Progesterone_Receptor	34,55	Progesterone	Progesterone Receptor	MESH:D011374	5241	Chemical	Gene	Withdrawal|compound|START_ENTITY Withdrawal|compound|END_ENTITY	Decreased DNA Methylations at the Progesterone_Receptor Promoter A Induce Functional Progesterone Withdrawal in Human Parturition .
26036900	0	Progesterone	60,72	Progesterone_Receptor	28,49	Progesterone	Progesterone Receptor	MESH:D011374	5241	Chemical	Gene	Action|compound|START_ENTITY Role|nmod|Action Role|nmod|END_ENTITY	The Role of a Mitochondrial Progesterone_Receptor -LRB- PR-M -RRB- in Progesterone Action .
26919974	0	Progesterone	0,12	Progesterone_Receptor	82,103	Progesterone	Progesterone Receptor	MESH:D011374	5241	Chemical	Gene	Inflammatory_Cytokine|compound|START_ENTITY Inflammatory_Cytokine|dep|Expression Expression|compound|END_ENTITY	Progesterone , Inflammatory_Cytokine -LRB- TNF-a -RRB- , and Oxidative Stress -LRB- H2O2 -RRB- Regulate Progesterone_Receptor Membrane Component 1 Expression in Fetal Membrane Cells .
12154395	0	Progesterone	0,12	TGF-b	25,30	Progesterone	TGF-b	MESH:D011374	7040	Chemical	Gene	upregulates|amod|START_ENTITY END_ENTITY|nsubj|upregulates	Progesterone upregulates TGF-b isoforms -LRB- b1 , b2 , and b3 -RRB- expression in normal human osteoblast-like cells .
15135803	0	Progesterone	0,12	TNF-alpha	50,59	Progesterone	TNF-alpha	MESH:D011374	7124	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|secretion secretion|amod|END_ENTITY	Progesterone , but not 17beta-estradiol , increases TNF-alpha secretion in U937 monocytes .
17275223	0	Progesterone	0,12	VEGF	75,79	Progesterone	VEGF	MESH:D011374	281572(Tax:9913)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|appos|END_ENTITY	Progesterone induces the expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- 120 and Flk-1 , its receptor , in bovine granulosa cells .
14662165	0	Progesterone	0,12	WT1	26,29	Progesterone	WT1	MESH:D011374	7490	Chemical	Gene	up-regulates|amod|START_ENTITY END_ENTITY|nsubj|up-regulates	Progesterone up-regulates WT1 mRNA and protein , and alters the relative expression of WT1 transcripts in cultured endometrial stromal cells .
19553525	0	Progesterone	0,12	activation-induced_deaminase	22,50	Progesterone	activation-induced deaminase	MESH:D011374	11628(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Progesterone inhibits activation-induced_deaminase by binding to the promoter .
8580890	0	Progesterone	0,12	angiotensin_II	118,132	Progesterone	angiotensin II	MESH:D011374	24179(Tax:10116)	Chemical	Gene	administration|amod|START_ENTITY reduces|nsubj|administration reduces|dobj|intake intake|acl|induced induced|nmod|administration administration|nmod|END_ENTITY	Progesterone administration to ovariectomized rats reduces water and salt intake induced by central administration of angiotensin_II .
25200987	0	Progesterone	0,12	aquaporin-4	24,35	Progesterone	aquaporin-4	MESH:D011374	25293(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|amod|END_ENTITY	Progesterone attenuates aquaporin-4 expression in an astrocyte model of ischemia/reperfusion .
10221591	0	Progesterone	0,12	beta-catenin	23,35	Progesterone	beta-catenin	MESH:D011374	1499	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|levels levels|amod|END_ENTITY	Progesterone regulates beta-catenin mRNA levels in human endometrial stromal cells in vitro .
15099674	0	Progesterone	0,12	brain-derived_neurotrophic_factor	35,68	Progesterone	brain-derived neurotrophic factor	MESH:D011374	24225(Tax:10116)	Chemical	Gene	up-regulates|amod|START_ENTITY neuronal|nsubj|up-regulates neuronal|dobj|expression expression|amod|END_ENTITY	Progesterone up-regulates neuronal brain-derived_neurotrophic_factor expression in the injured spinal cord .
15862959	0	Progesterone	0,12	brain-derived_neurotrophic_factor	77,110	Progesterone	brain-derived neurotrophic factor	MESH:D011374	24225(Tax:10116)	Chemical	Gene	neuroprotection|amod|START_ENTITY involves|nsubj|neuroprotection involves|dobj|up-regulation up-regulation|nmod|END_ENTITY	Progesterone neuroprotection in spinal cord trauma involves up-regulation of brain-derived_neurotrophic_factor in motoneurons .
17052708	0	Progesterone	0,12	brain-derived_neurotrophic_factor	23,56	Progesterone	brain-derived neurotrophic factor	MESH:D011374	12064(Tax:10090)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Progesterone modulates brain-derived_neurotrophic_factor and choline_acetyltransferase in degenerating Wobbler motoneurons .
22123169	0	Progesterone	0,12	brain-derived_neurotrophic_factor	33,66	Progesterone	brain-derived neurotrophic factor	MESH:D011374	12064(Tax:10090)	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|END_ENTITY	Progesterone effects on neuronal brain-derived_neurotrophic_factor and glial cells during progression of Wobbler_mouse_neurodegeneration .
22778217	0	Progesterone	0,12	brain-derived_neurotrophic_factor	38,71	Progesterone	brain-derived neurotrophic factor	MESH:D011374	627	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|release release|nmod|END_ENTITY	Progesterone increases the release of brain-derived_neurotrophic_factor from glia via progesterone_receptor_membrane_component_1 -LRB- Pgrmc1 -RRB- - dependent ERK5 signaling .
12606445	0	Progesterone	0,12	calcitonin	21,31	Progesterone	calcitonin	MESH:D011374	24241(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Progesterone induces calcitonin expression in the baboon endometrium within the window of uterine receptivity .
17689241	0	Progesterone	0,12	catechol-O-methyl_transferase	23,52	Progesterone	catechol-O-methyl transferase	MESH:D011374	1312	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Progesterone regulates catechol-O-methyl_transferase gene expression in breast_cancer cells : distinct effect of progesterone_receptor isoforms .
17492661	0	Progesterone	0,12	csk_homologous_kinase	23,44	Progesterone	csk homologous kinase	MESH:D011374	4145	Chemical	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	Progesterone increases csk_homologous_kinase in HMC-1560 human mast cells and reduces cell proliferation .
10022912	0	Progesterone	0,12	cyclin_D1	39,48	Progesterone	cyclin D1	MESH:D011374	12443(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Progesterone inhibits estrogen-induced cyclin_D1 and cdk4 nuclear translocation , cyclin E - and cyclin_A-cdk2 kinase activation , and cell proliferation in uterine epithelial cells in mice .
15845746	0	Progesterone	0,12	cyclin_D1	89,98	Progesterone	cyclin D1	MESH:D011374	595	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|> >|dep|GSK-3beta GSK-3beta|dep|END_ENTITY	Progesterone inhibits the estrogen-induced phosphoinositide 3-kinase -- > AKT -- > GSK-3beta -- > cyclin_D1 -- > pRB pathway to block uterine epithelial cell proliferation .
9275084	0	Progesterone	0,12	cyclin_D1	47,56	Progesterone	cyclin D1	MESH:D011374	12443(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Progesterone , in addition to estrogen , induces cyclin_D1 expression in the murine mammary epithelial cell , in vivo .
23929706	0	Progesterone	0,12	cyclooxygenase-2	46,62	Progesterone	cyclooxygenase-2	MESH:D011374	29527(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|nmod|END_ENTITY	Progesterone reduces the expression of spinal cyclooxygenase-2 and inducible_nitric_oxide_synthase and prevents allodynia in a rat model of central neuropathic_pain .
23545163	0	Progesterone	0,12	endothelin-1	60,72	Progesterone	endothelin-1	MESH:D011374	1906	Chemical	Gene	blunts|amod|START_ENTITY vascular|nsubj|blunts vascular|dobj|secretion secretion|nmod|END_ENTITY	Progesterone blunts vascular endothelial cell secretion of endothelin-1 in response to placental ischemia .
10377066	0	Progesterone	0,12	epidermal_growth_factor_receptor	27,59	Progesterone	epidermal growth factor receptor	MESH:D011374	24329(Tax:10116)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Progesterone regulation of epidermal_growth_factor_receptor in rat decidua basalis during pregnancy .
1915088	0	Progesterone	0,12	epidermal_growth_factor_receptor	23,55	Progesterone	epidermal growth factor receptor	MESH:D011374	100008806(Tax:9986)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Progesterone regulates epidermal_growth_factor_receptor on mucous secreting cells in the rabbit endocervix .
1916218	0	Progesterone	0,12	estrogen_receptor	58,75	Progesterone	estrogen receptor	MESH:D011374	2099	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dep|END_ENTITY	Progesterone downregulates progesterone receptor , but not estrogen_receptor , in the estrogen-primed oviduct of a turtle -LRB- Trachemys_scripta -RRB- .
3240853	0	Progesterone	0,12	estrogen_receptor	40,57	Progesterone	estrogen receptor	MESH:D011374	2099	Chemical	Gene	down-regulation|amod|START_ENTITY down-regulation|nmod|END_ENTITY	Progesterone down-regulation of nuclear estrogen_receptor : a fundamental mechanism in birds and mammals .
4040190	0	Progesterone	0,12	estrogen_receptor	32,49	Progesterone	estrogen receptor	MESH:D011374	2099	Chemical	Gene	control|amod|START_ENTITY control|nmod|END_ENTITY	Progesterone control of nuclear estrogen_receptor : demonstration in hamster uterus during the estrous cycle and pseudopregnancy using a new exchange assay .
7280669	0	Progesterone	0,12	estrogen_receptor	56,73	Progesterone	estrogen receptor	MESH:D011374	2099	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Progesterone regulation of the occupied form of nuclear estrogen_receptor .
15774544	0	Progesterone	0,12	fibulin-1	25,34	Progesterone	fibulin-1	MESH:D011374	2192	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Progesterone induces the fibulin-1 expression in human endometrial stromal cells .
23209664	0	Progesterone	0,12	glucocorticoid_receptor	34,57	Progesterone	glucocorticoid receptor	MESH:D011374	2908	Chemical	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	Progesterone acts via the nuclear glucocorticoid_receptor to suppress IL-1b-induced COX-2 expression in human term myometrial cells .
11408779	0	Progesterone	0,12	gonadotropin-releasing_hormone	76,106	Progesterone	gonadotropin-releasing hormone	MESH:D011374	2796	Chemical	Gene	treatment|amod|START_ENTITY treatment|acl:relcl|blocks blocks|dobj|surge surge|amod|END_ENTITY	Progesterone treatment that either blocks or augments the estradiol-induced gonadotropin-releasing_hormone surge is associated with different patterns of hypothalamic neural activation .
15728200	0	Progesterone	0,12	gonadotropin-releasing_hormone	44,74	Progesterone	gonadotropin-releasing hormone	MESH:D011374	2796	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|generator generator|amod|END_ENTITY	Progesterone inhibition of the hypothalamic gonadotropin-releasing_hormone pulse generator : evidence for varied effects in hyperandrogenemic_adolescent_girls .
15796768	0	Progesterone	0,12	gonadotropin-releasing_hormone	40,70	Progesterone	gonadotropin-releasing hormone	MESH:D011374	2796	Chemical	Gene	block|nsubj|START_ENTITY block|dobj|surge surge|amod|END_ENTITY	Progesterone can block the preovulatory gonadotropin-releasing_hormone / luteinising hormone surge in the ewe by a direct inhibitory action on oestradiol-responsive cells within the hypothalamus .
1595327	0	Progesterone	0,12	gonadotropin-releasing_hormone	57,87	Progesterone	gonadotropin-releasing hormone	MESH:D011374	25194(Tax:10116)	Chemical	Gene	beta|amod|START_ENTITY inhibit|nsubj|beta inhibit|dobj|stimulation stimulation|amod|END_ENTITY	Progesterone , testosterone and estradiol-17 beta inhibit gonadotropin-releasing_hormone stimulation of G protein GTPase activity in plasma membranes from rat anterior pituitary lobe .
16726114	0	Progesterone	0,12	gonadotropin-releasing_hormone	98,128	Progesterone	gonadotropin-releasing hormone	MESH:D011374	2796	Chemical	Gene	secretion|amod|START_ENTITY bitches|nsubj|secretion bitches|nmod|administration administration|nmod|END_ENTITY	Progesterone secretion by induced corpora lutea -LRB- CL -RRB- of anestrous bitches after administration of gonadotropin-releasing_hormone -LRB- GnRH -RRB- and human chorionic gonadotropin -LRB- HOG -RRB- .
20739401	0	Progesterone	0,12	gonadotropin-releasing_hormone	118,148	Progesterone	gonadotropin-releasing hormone	MESH:D011374	14714(Tax:10090)	Chemical	Gene	inhibits|amod|START_ENTITY potentiates|nsubj|inhibits potentiates|dobj|currents currents|nmod|neurons neurons|amod|END_ENTITY	Progesterone treatment inhibits and dihydrotestosterone -LRB- DHT -RRB- treatment potentiates voltage-gated calcium currents in gonadotropin-releasing_hormone -LRB- GnRH -RRB- neurons .
2121554	0	Progesterone	0,12	gonadotropin-releasing_hormone	93,123	Progesterone	gonadotropin-releasing hormone	MESH:D011374	2796	Chemical	Gene	levels|amod|START_ENTITY levels|nmod|day day|nmod|administration administration|nmod|cycles cycles|nmod|suppression suppression|amod|END_ENTITY	Progesterone levels on the day of human chorionic gonadotropin administration in cycles with gonadotropin-releasing_hormone agonist suppression are not predictive of pregnancy outcome .
9886822	0	Progesterone	0,12	gonadotropin-releasing_hormone	132,162	Progesterone	gonadotropin-releasing hormone	MESH:D011374	2796	Chemical	Gene	priming|amod|START_ENTITY essential|nsubj|priming essential|advcl|inducing inducing|dobj|surge surge|amod|END_ENTITY	Progesterone priming is essential for the full expression of the positive feedback effect of estradiol in inducing the preovulatory gonadotropin-releasing_hormone surge in the ewe .
9927312	0	Progesterone	0,12	gonadotropin-releasing_hormone	178,208	Progesterone	gonadotropin-releasing hormone	MESH:D011374	2796	Chemical	Gene	block|nsubj|START_ENTITY block|advcl|luteinizing luteinizing|nmod|activation activation|nmod|system system|amod|END_ENTITY	Progesterone can block transmission of the estradiol-induced signal for luteinizing hormone surge generation during a specific period of time immediately after activation of the gonadotropin-releasing_hormone surge-generating system .
21324450	0	Progesterone	0,12	hCG	66,69	Progesterone	hCG	MESH:D011374	3342	Chemical	Gene	level|amod|START_ENTITY level|nmod|day day|nmod|administration administration|compound|END_ENTITY	Progesterone level and progesterone/estradiol ratio on the day of hCG administration : detrimental cutoff levels and new treatment strategy .
25210608	0	Progesterone	20,32	hCG	53,56	Progesterone	hCG	MESH:D011374	3342	Chemical	Gene	Level|compound|START_ENTITY Level|nmod|Day Day|nmod|Injection Injection|compound|END_ENTITY	Assessment of Serum Progesterone Level on the Day of hCG Injection in Infertile_Polycystic_Ovarian_Syndrome Patients Referred to Women 's Hospital , Tehran , 2009 .
7065025	4	Progesterone	549,561	hCG	580,583	Progesterone	hCG	MESH:D011374	93659	Chemical	Gene	START_ENTITY|acl:relcl|suppresses suppresses|dobj|END_ENTITY	Progesterone , which suppresses hCG under these conditions , decreased the cortisol-enhanced secretion of hCG -LRB- r = -0.9794 ; P less than 0.01 -RRB- .
8520185	0	Progesterone	0,12	hCG	88,91	Progesterone	hCG	MESH:D011374	3342	Chemical	Gene	concentration|amod|START_ENTITY mIU/mL|nsubj|concentration mIU/mL|amod|useful useful|ccomp|less less|nsubj|levels levels|compound|END_ENTITY	Progesterone concentration as a predictor of pregnancy normalcy is the most useful when hCG levels are less than 2000 mIU/mL .
8070371	0	Progesterone	0,12	heparin-binding_epidermal_growth_factor-like_growth_factor	27,85	Progesterone	heparin-binding epidermal growth factor-like growth factor	MESH:D011374	25433(Tax:10116)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Progesterone regulation of heparin-binding_epidermal_growth_factor-like_growth_factor gene expression during sensitization and decidualization in the rat uterus : effects of the antiprogestin , ZK 98.299 .
18824770	0	Progesterone	0,12	human_leukocyte_antigen-g	21,46	Progesterone	human leukocyte antigen-g	MESH:D011374	3135	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Progesterone induces human_leukocyte_antigen-g expression in vascular endothelial and smooth muscle cells .
15033949	0	Progesterone	0,12	insulin-like_growth_factor-I	28,56	Progesterone	insulin-like growth factor-I	MESH:D011374	3479	Chemical	Gene	down-regulates|amod|START_ENTITY END_ENTITY|nsubj|down-regulates	Progesterone down-regulates insulin-like_growth_factor-I expression in cultured human uterine leiomyoma cells .
15501902	0	Progesterone	0,12	insulin-like_growth_factor_binding_protein-1	22,66	Progesterone	insulin-like growth factor binding protein-1	MESH:D011374	3484	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Progesterone inhibits insulin-like_growth_factor_binding_protein-1 -LRB- IGFBP-1 -RRB- production by explants of the Fallopian tube .
11134140	0	Progesterone	0,12	interleukin-15	22,36	Progesterone	interleukin-15	MESH:D011374	3600	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|amod|END_ENTITY	Progesterone enhances interleukin-15 production in human endometrial stromal cells in vitro .
2584355	0	Progesterone	0,12	interleukin-1_beta	36,54	Progesterone	interleukin-1 beta	MESH:D011374	3553	Chemical	Gene	modulate|nsubj|START_ENTITY modulate|ccomp|ribonucleic_acid ribonucleic_acid|nsubj|messenger messenger|amod|END_ENTITY	Progesterone and estradiol modulate interleukin-1_beta messenger ribonucleic_acid levels in cultured human peripheral monocytes .
17000234	0	Progesterone	0,12	interleukin-6	48,61	Progesterone	interleukin-6	MESH:D011374	3569	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|lipopolysaccharide lipopolysaccharide|acl|induced induced|dobj|secretion secretion|amod|END_ENTITY	Progesterone reduces lipopolysaccharide induced interleukin-6 secretion in fetoplacental chorionic arteries , fractionated cord blood , and maternal mononuclear cells .
22122352	0	Progesterone	0,12	interleukin-6	41,54	Progesterone	interleukin-6	MESH:D011374	3569	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|fibroblasts fibroblasts|amod|END_ENTITY	Progesterone modulates the expression of interleukin-6 in cultured term human uterine cervical fibroblasts .
24548847	0	Progesterone	0,12	interleukin-6	138,151	Progesterone	interleukin-6	MESH:D011374	24498(Tax:10116)	Chemical	Gene	supplementation|amod|START_ENTITY attenuates|nsubj|supplementation attenuates|nmod|END_ENTITY	Progesterone supplementation attenuates hypertension and the autoantibody to the angiotensin II type I receptor in response to elevated interleukin-6 during pregnancy .
12672669	0	Progesterone	0,12	interleukin-8	23,36	Progesterone	interleukin-8	MESH:D011374	3576	Chemical	Gene	represses|nsubj|START_ENTITY represses|xcomp|END_ENTITY	Progesterone represses interleukin-8 and cyclo-oxygenase-2 in human lower segment fibroblast cells and amnion epithelial cells .
15866594	0	Progesterone	0,12	interleukin-8	88,101	Progesterone	interleukin-8	MESH:D011374	3576	Chemical	Gene	compounds|amod|START_ENTITY attenuate|nsubj|compounds attenuate|dobj|production production|amod|END_ENTITY	Progesterone and progestational compounds attenuate tumor_necrosis_factor_alpha-induced interleukin-8 production via nuclear factor kappa B inactivation in endometriotic stromal cells .
8027281	0	Progesterone	0,12	interleukin-8	24,37	Progesterone	interleukin-8	MESH:D011374	3576	Chemical	Gene	control|amod|START_ENTITY control|nmod|production production|amod|END_ENTITY	Progesterone control of interleukin-8 production in endometrium and chorio-decidual cells underlines the role of the neutrophil in menstruation and parturition .
11385112	0	Progesterone	0,12	leptin_receptor	38,53	Progesterone	leptin receptor	MESH:D011374	3953	Chemical	Gene	inhibition|amod|START_ENTITY END_ENTITY|nsubj|inhibition	Progesterone inhibition of functional leptin_receptor mRNA expression in human endometrium .
19060097	0	Progesterone	0,12	leukemia_inhibitory_factor	41,67	Progesterone	leukemia inhibitory factor	MESH:D011374	101110180	Chemical	Gene	tau|nsubj|START_ENTITY tau|xcomp|regulate regulate|dobj|receptor receptor|compound|END_ENTITY	Progesterone and interferon tau regulate leukemia_inhibitory_factor receptor and IL6ST in the ovine uterus during early pregnancy .
7956912	0	Progesterone	0,12	macrophage_colony-stimulating_factor	22,58	Progesterone	macrophage colony-stimulating factor	MESH:D011374	1435	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|amod|END_ENTITY	Progesterone enhances macrophage_colony-stimulating_factor production in human endometrial stromal cells in vitro .
25241899	0	Progesterone	0,12	miR-141	31,38	Progesterone	miR-141	MESH:D011374	406933	Chemical	Gene	downregulation|amod|START_ENTITY downregulation|nmod|END_ENTITY	Progesterone downregulation of miR-141 contributes to expansion of stem-like breast_cancer cells through maintenance of progesterone_receptor and Stat5a .
9499459	0	Progesterone	0,12	mucin	68,73	Progesterone	mucin	MESH:D011374	100508689	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|nmod|END_ENTITY	Progesterone stimulates production and secretion of MUC1 epithelial mucin in steroid-responsive breast_cancer cell lines .
16337358	0	Progesterone	0,12	multidrug_resistance_type_I	58,85	Progesterone	multidrug resistance type I	MESH:D011374	5243	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|nmod|END_ENTITY	Progesterone regulation of the expression and function of multidrug_resistance_type_I in porcine granulosa cells .
16503802	0	Progesterone	0,12	myelin_basic_protein	41,61	Progesterone	myelin basic protein	MESH:D011374	24547(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Progesterone increases the expression of myelin_basic_protein and the number of cells showing NG2 immunostaining in the lesioned spinal cord .
9322944	0	Progesterone	0,12	osteopontin	23,34	Progesterone	osteopontin	MESH:D011374	6696	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Progesterone regulates osteopontin expression in human trophoblasts : a model of paracrine control in the placenta ?
12733588	0	Progesterone	0,12	phospholipase_A2	78,94	Progesterone	phospholipase A2	MESH:D011374	151056	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Progesterone regulates IL12 expression in pregnancy lymphocytes by inhibiting phospholipase_A2 .
10891585	0	Progesterone	0,12	pituitary_adenylate_cyclase-activating_polypeptide	38,88	Progesterone	pituitary adenylate cyclase-activating polypeptide	MESH:D011374	24166(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|nmod|END_ENTITY	Progesterone increases mRNA levels of pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- and type I PACAP receptor -LRB- PAC -LRB- 1 -RRB- -RRB- in the rat hypothalamus .
2420291	0	Progesterone	0,12	pregnancy-associated_plasma_protein-A	57,94	Progesterone	pregnancy-associated plasma protein-A	MESH:D011374	5069	Chemical	Gene	dependence|amod|START_ENTITY dependence|nmod|END_ENTITY	Progesterone dependence and extratrophoblastic origin of pregnancy-associated_plasma_protein-A -LRB- PAPP-A -RRB- in early pregnancy .
10707953	0	Progesterone	0,12	progesterone_receptor	87,108	Progesterone	progesterone receptor	MESH:D011374	5241	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|MDA-MB-231 MDA-MB-231|acl|transfected transfected|nmod|DNA DNA|amod|END_ENTITY	Progesterone induces focal adhesion in breast_cancer cells MDA-MB-231 transfected with progesterone_receptor complementary DNA .
10965915	0	Progesterone	0,12	progesterone_receptor	31,52	Progesterone	progesterone receptor	MESH:D011374	25154(Tax:10116)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Progesterone regulation of the progesterone_receptor in rat gonadotropes .
12759236	0	Progesterone	0,12	progesterone_receptor	97,118	Progesterone	progesterone receptor	MESH:D011374	5241	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|cells cells|acl|transfected transfected|nmod|DNA DNA|amod|END_ENTITY	Progesterone induces cellular differentiation in MDA-MB-231_breast_cancer cells transfected with progesterone_receptor complementary DNA .
14667968	0	Progesterone	0,12	progesterone_receptor	81,102	Progesterone	progesterone receptor	MESH:D011374	18667(Tax:10090)	Chemical	Gene	involvement|amod|START_ENTITY involvement|dep|revealed revealed|nmod|models models|compound|END_ENTITY	Progesterone involvement in breast development and tumorigenesis -- as revealed by progesterone_receptor `` knockout '' and `` knockin '' mouse models .
1569831	0	Progesterone	0,12	progesterone_receptor	27,48	Progesterone	progesterone receptor	MESH:D011374	5241	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Progesterone regulation of progesterone_receptor in mesometrial and antimesometrial deciduoma in pseudopregnant hamster .
17689241	0	Progesterone	0,12	progesterone_receptor	112,133	Progesterone	progesterone receptor	MESH:D011374	5241	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|dep|effect effect|nmod|isoforms isoforms|compound|END_ENTITY	Progesterone regulates catechol-O-methyl_transferase gene expression in breast_cancer cells : distinct effect of progesterone_receptor isoforms .
19417032	0	Progesterone	0,12	progesterone_receptor	25,46	Progesterone	progesterone receptor	MESH:D011374	5241	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|mechanism mechanism|amod|END_ENTITY	Progesterone activates a progesterone_receptor membrane component 1-dependent mechanism that promotes human granulosa/luteal cell survival but not progesterone secretion .
20087430	0	Progesterone	0,12	progesterone_receptor	52,73	Progesterone	progesterone receptor	MESH:D011374	5241	Chemical	Gene	action|amod|START_ENTITY action|dep|regulation regulation|nmod|END_ENTITY	Progesterone action in human tissues : regulation by progesterone_receptor -LRB- PR -RRB- isoform expression , nuclear positioning and coregulator expression .
21291899	0	Progesterone	0,12	progesterone_receptor	207,228	Progesterone	progesterone receptor	MESH:D011374	5241	Chemical	Gene	signals|nsubj|START_ENTITY signals|nmod|progesterone_receptors progesterone_receptors|acl:relcl|lack lack|dobj|isoforms isoforms|nmod|END_ENTITY	Progesterone signals through membrane progesterone_receptors -LRB- mPRs -RRB- in MDA-MB-468 and mPR-transfected MDA-MB-231 breast_cancer cells which lack full-length and N-terminally truncated isoforms of the nuclear progesterone_receptor .
22564730	0	Progesterone	0,12	progesterone_receptor	73,94	Progesterone	progesterone receptor	MESH:D011374	5241	Chemical	Gene	START_ENTITY|dep|regulate regulate|dobj|expression expression|nmod|17bHSD-enzymes 17bHSD-enzymes|nmod|T47D T47D|amod|END_ENTITY	Progesterone and levonorgestrel regulate expression of 17bHSD-enzymes in progesterone_receptor positive breast_cancer cell line T47D .
2378939	0	Progesterone	0,12	progesterone_receptor	42,63	Progesterone	progesterone receptor	MESH:D011374	25154(Tax:10116)	Chemical	Gene	maintenance|amod|START_ENTITY maintenance|nmod|END_ENTITY	Progesterone maintenance of the placental progesterone_receptor and placental growth in ovariectomized rats .
23970345	0	Progesterone	0,12	progesterone_receptor	93,114	Progesterone	progesterone receptor	MESH:D011374	5241	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|component component|compound|END_ENTITY	Progesterone protects ovarian_cancer cells from cisplatin-induced inhibitory effects through progesterone_receptor membrane component 1/2 as well as AKT signaling .
25241899	0	Progesterone	0,12	progesterone_receptor	120,141	Progesterone	progesterone receptor	MESH:D011374	5241	Chemical	Gene	downregulation|amod|START_ENTITY contributes|nsubj|downregulation contributes|nmod|maintenance maintenance|nmod|END_ENTITY	Progesterone downregulation of miR-141 contributes to expansion of stem-like breast_cancer cells through maintenance of progesterone_receptor and Stat5a .
26916548	0	Progesterone	0,12	progesterone_receptor	26,47	Progesterone	progesterone receptor	MESH:D011374	5241	Chemical	Gene	acts|amod|START_ENTITY acts|nmod|END_ENTITY	Progesterone acts via the progesterone_receptor to induce adamts proteases in ovarian_cancer cells .
22822163	0	Progesterone	0,12	progesterone_receptor_membrane_component_1	70,112	Progesterone	progesterone receptor membrane component 1	MESH:D011374	53328(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	Progesterone directly and rapidly inhibits GnRH neuronal activity via progesterone_receptor_membrane_component_1 .
122417	0	Progesterone	0,12	prolactin	38,47	Progesterone	prolactin	MESH:D011374	5617	Chemical	Gene	induced|nsubj|START_ENTITY induced|dobj|release release|nmod|END_ENTITY	Progesterone induced acute release of prolactin in estrogen primed ovariectomized women .
2305604	0	Progesterone	0,12	prolactin	27,36	Progesterone	prolactin	MESH:D011374	5617	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|release release|compound|END_ENTITY	Progesterone regulation of prolactin release from human endometrial stromal cells in culture : potential bioassay for progestational activity .
6440662	0	Progesterone	0,12	prolactin	22,31	Progesterone	prolactin	MESH:D011374	5617	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|compound|END_ENTITY	Progesterone inhibits prolactin and growth hormone release from fowl pituitary glands in vitro .
8319833	0	Progesterone	0,12	prolactin	43,52	Progesterone	prolactin	MESH:D011374	24683(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Progesterone inhibits the estrogen-induced prolactin gene expression in the rat pituitary .
9058009	0	Progesterone	0,12	prolactin	44,53	Progesterone	prolactin	MESH:D011374	24683(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|advcl|involving involving|nsubj|release release|nmod|END_ENTITY	Progesterone stimulates in vitro release of prolactin and thyrotropin involving cAMP production in rat pituitary .
21238538	0	Progesterone	0,12	prolactin_receptor	39,57	Progesterone	prolactin receptor	MESH:D011374	5618	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|gene gene|compound|END_ENTITY	Progesterone induces expression of the prolactin_receptor gene through cooperative action of Sp1 and C/EBP .
7977707	0	Progesterone	0,12	prolactin_receptor	49,67	Progesterone	prolactin receptor	MESH:D011374	19116(Tax:10090)	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|END_ENTITY	Progesterone and EGF inhibit mouse mammary gland prolactin_receptor and beta-casein gene expression .
24336673	0	Progesterone	0,12	secretin	23,31	Progesterone	secretin	MESH:D011374	20287(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Progesterone regulates secretin expression in mouse uterus during early pregnancy .
11034074	0	Progesterone	0,12	telomerase_reverse_transcriptase	29,61	Progesterone	telomerase reverse transcriptase	MESH:D011374	7015	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Progesterone regulates human telomerase_reverse_transcriptase gene expression via activation of mitogen-activated protein kinase signaling pathway .
20535645	0	Progesterone	0,12	transthyretin	22,35	Progesterone	transthyretin	MESH:D011374	24856(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	Progesterone enhances transthyretin expression in the rat choroid plexus in vitro and in vivo via progesterone_receptor .
17396998	0	Progesterone	0,12	tumor_necrosis_factor	99,120	Progesterone	tumor necrosis factor	MESH:D011374	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|inhibition inhibition|nmod|secretion secretion|compound|END_ENTITY	Progesterone inhibits HIV-1 replication in human trophoblast cells through inhibition of autocrine tumor_necrosis_factor secretion .
2620073	0	Progesterone	0,12	uterine_milk_proteins	30,51	Progesterone	uterine milk proteins	MESH:D011374	443315(Tax:9940)	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Progesterone induction of the uterine_milk_proteins : major secretory proteins of sheep endometrium .
11156860	0	Progesterone	0,12	vascular_cell_adhesion_molecule-1	52,85	Progesterone	vascular cell adhesion molecule-1	MESH:D011374	7412	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Progesterone , but not medroxyprogesterone , inhibits vascular_cell_adhesion_molecule-1 expression in human vascular endothelial cells .
10999847	0	Progesterone	0,12	vascular_endothelial_growth_factor	37,71	Progesterone	vascular endothelial growth factor	MESH:D011374	7422	Chemical	Gene	up-regulates|amod|START_ENTITY END_ENTITY|nsubj|up-regulates	Progesterone withdrawal up-regulates vascular_endothelial_growth_factor receptor type 2 in the superficial zone stroma of the human and macaque endometrium : potential relevance to menstruation .
17275223	0	Progesterone	0,12	vascular_endothelial_growth_factor	39,73	Progesterone	vascular endothelial growth factor	MESH:D011374	281572(Tax:9913)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Progesterone induces the expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- 120 and Flk-1 , its receptor , in bovine granulosa cells .
8684267	0	Progesterone	0,12	vascular_endothelial_growth_factor	21,55	Progesterone	vascular endothelial growth factor	MESH:D011374	7422	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Progesterone induces vascular_endothelial_growth_factor on retinal pigment epithelial cells in culture .
12027886	0	Progestin	0,9	G-protein-coupled_receptor_30	22,51	Progestin	G-protein-coupled receptor 30	CHEBI:59826	2852	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	Progestin upregulates G-protein-coupled_receptor_30 in breast_cancer cells .
3265383	0	Progestin	0,9	epidermal_growth_factor	123,146	Progestin	epidermal growth factor	CHEBI:59826	25313(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|nmod|reference reference|nmod|END_ENTITY	Progestin and estrogen receptors : characterization and localization in rat submandibular glands , with special reference to epidermal_growth_factor .
15998775	0	Progestin	0,9	interleukin-11	61,75	Progestin	interleukin-11	CHEBI:59826	3589	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|production production|amod|END_ENTITY	Progestin suppresses thrombin - and interleukin-1beta-induced interleukin-11 production in term decidual cells : implications for preterm_delivery .
20962051	0	Progestin	0,9	mPRa	28,32	Progestin	mPRa	CHEBI:59826	20200(Tax:10090)	Chemical	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Progestin signaling through mPRa in Atlantic croaker granulosa/theca cell cocultures and its involvement in progestin inhibition of apoptosis .
15998775	0	Progestin	0,9	thrombin	21,29	Progestin	thrombin	CHEBI:59826	2147	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|production production|amod|END_ENTITY	Progestin suppresses thrombin - and interleukin-1beta-induced interleukin-11 production in term decidual cells : implications for preterm_delivery .
1649393	0	Progestins	0,10	IGF-II	142,148	Progestins	IGF-II	MESH:D011372	3481	Chemical	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Progestins induce down-regulation of insulin-like_growth_factor-I -LRB- IGF-I -RRB- receptors in human breast_cancer cells : potential autocrine role of IGF-II .
25806402	0	Progestins	14,24	Matrix_Metalloproteinase-9	60,86	Progestins	Matrix Metalloproteinase-9	MESH:D011372	4318	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|Activity Activity|compound|END_ENTITY	The Effect of Progestins on Tumor_Necrosis_Factor_a-Induced Matrix_Metalloproteinase-9 Activity and Gene Expression in Human Primary Amnion and Chorion Cells In Vitro .
10454244	0	Progestins	0,10	VEGF	87,91	Progestins	VEGF	MESH:D011372	7422	Chemical	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Progestins suppress estrogen-induced expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- subtypes in uterine endometrial_cancer cells .
11108887	0	Progestins	0,10	VEGF	82,86	Progestins	VEGF	MESH:D011372	7422	Chemical	Gene	change|nsubj|START_ENTITY change|dobj|release release|amod|END_ENTITY	Progestins , progesterone_receptor modulators , and progesterone antagonists change VEGF release of endometrial cells in culture .
10454244	0	Progestins	0,10	vascular_endothelial_growth_factor	51,85	Progestins	vascular endothelial growth factor	MESH:D011372	7422	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Progestins suppress estrogen-induced expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- subtypes in uterine endometrial_cancer cells .
21774929	0	Progestins	0,10	vascular_endothelial_growth_factor	37,71	Progestins	vascular endothelial growth factor	MESH:D011372	7422	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|END_ENTITY	Progestins inhibit estradiol-induced vascular_endothelial_growth_factor and stromal cell-derived factor 1 in human endometrial stromal cells .
2396199	0	Proglumide	0,10	cholecystokinin	20,35	Proglumide	cholecystokinin	null	609547(Tax:9615)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Proglumide inhibits cholecystokinin and meal-stimulated pancreatic secretion and release of pancreatic_polypeptide .
2894431	0	Proglumide	0,10	cholecystokinin	14,29	Proglumide	cholecystokinin	null	885	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Proglumide , a cholecystokinin receptor antagonist , exacerbates alloxan-induced diabetes_mellitus in Swiss mice .
3812772	0	Proglumide	0,10	cholecystokinin	14,29	Proglumide	cholecystokinin	null	25298(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Proglumide , a cholecystokinin antagonist , increases gastric emptying in rats .
2994583	0	Proglumide	0,10	gastrin	14,21	Proglumide	gastrin	null	14459(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Proglumide , a gastrin receptor antagonist , inhibits growth of colon_cancer and enhances survival in mice .
8168618	0	Prolactin	0,9	GLUT2	30,35	Prolactin	GLUT2	MESH:D011388	25351(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY increases|nsubj|treatment increases|dobj|END_ENTITY	Prolactin treatment increases GLUT2 but not the G protein subunit content in cell membranes from cultured neonatal rat islets .
25231888	0	Prolinamide	0,11	thrombin	27,35	Prolinamide	thrombin	CHEBI:21374	2147	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|inhibitors inhibitors|compound|END_ENTITY	Prolinamide derivatives as thrombin inhibitors for the treatment of thrombin-mediated diseases : a patent evaluation of US2013296245 .
10430626	0	Proline	0,7	CD28	20,24	Proline	CD28	CHEBI:26271	940	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Proline residues in CD28 and the Src homology -LRB- SH -RRB- 3 domain of Lck are required for T cell costimulation .
21834515	0	Proline	0,7	DPP-IV	51,57	Proline	DPP-IV	CHEBI:26271	1803	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Proline in transmembrane domain of type II protein DPP-IV governs its translocation behavior through endoplasmic reticulum .
10430626	0	Proline	0,7	Lck	62,65	Proline	Lck	CHEBI:26271	3932	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Proline residues in CD28 and the Src homology -LRB- SH -RRB- 3 domain of Lck are required for T cell costimulation .
12603084	0	Proline	0,7	acetylcholinesterase	16,36	Proline	acetylcholinesterase	CHEBI:26271	83817(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|activity activity|amod|END_ENTITY	Proline reduces acetylcholinesterase activity in cerebral cortex of rats .
18369157	0	Proline	0,7	matrix_Gla_protein	53,71	Proline	matrix Gla protein	CHEBI:26271	402937(Tax:7955)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Proline and gamma-carboxylated_glutamate residues in matrix_Gla_protein are critical for binding of bone_morphogenetic_protein-4 .
21890735	0	Proluciferin_acetals	0,20	CYP3A	94,99	Proluciferin acetals	CYP3A	null	1576	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|compound|END_ENTITY	Proluciferin_acetals as bioluminogenic substrates for cytochrome_P450 activity and probes for CYP3A inhibition .
21890735	0	Proluciferin_acetals	0,20	cytochrome_P450	54,69	Proluciferin acetals	cytochrome P450	null	4051	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Proluciferin_acetals as bioluminogenic substrates for cytochrome_P450 activity and probes for CYP3A inhibition .
25667458	0	Prolyl	0,6	PIN1	17,21	Prolyl	PIN1	CHEBI:26274	5300	Chemical	Gene	Stability|compound|START_ENTITY Stability|compound|END_ENTITY	Prolyl Isomerase PIN1 Negatively Regulates SGK1 Stability to Mediate Tamoxifen Resistance in Breast_Cancer Cells .
16820873	0	Prolyl	0,6	Pin1	17,21	Prolyl	Pin1	CHEBI:26274	5300	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Prolyl isomerase Pin1 expression predicts prognosis in patients with esophageal_squamous_cell_carcinoma and correlates with cyclinD1 expression .
17965833	0	Prolyl	0,6	Pin1	18,22	Prolyl	Pin1	CHEBI:26274	5300	Chemical	Gene	isomerase|amod|START_ENTITY isomerase|appos|END_ENTITY	Prolyl isomerase , Pin1 : new findings of post-translational modifications and physiological substrates in cancer , asthma and Alzheimer 's _ disease .
24509851	0	Prolyl	0,6	Runx2	90,95	Prolyl	Runx2	CHEBI:26274	860	Chemical	Gene	change|amod|START_ENTITY change|nmod|END_ENTITY	Prolyl isomerase Pin1-mediated conformational change and subnuclear focal accumulation of Runx2 are crucial for fibroblast_growth_factor_2 -LRB- FGF2 -RRB- - induced osteoblast differentiation .
25667458	0	Prolyl	0,6	SGK1	43,47	Prolyl	SGK1	CHEBI:26274	6446	Chemical	Gene	Stability|compound|START_ENTITY Stability|compound|END_ENTITY	Prolyl Isomerase PIN1 Negatively Regulates SGK1 Stability to Mediate Tamoxifen Resistance in Breast_Cancer Cells .
11312646	0	Propanil	0,8	tumor_necrosis_factor-alpha	18,45	Propanil	tumor necrosis factor-alpha	MESH:D011411	21926(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Propanil inhibits tumor_necrosis_factor-alpha production by reducing nuclear levels of the transcription factor nuclear_factor-kappab in the macrophage cell line ic-21 .
9839653	0	Propentofylline	0,15	TNFalpha	39,47	Propentofylline	TNFalpha	MESH:C032114	21926(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|nmod|END_ENTITY	Propentofylline inhibits production of TNFalpha and infection_of_LP-BM5_murine_leukemia virus in glial cells .
26875495	0	Propionate	0,10	Peroxisome_Proliferator-Activated_Receptor_a	70,114	Propionate	Peroxisome Proliferator-Activated Receptor a	CHEBI:17272	19013(Tax:10090)	Chemical	Gene	Oxidation|compound|START_ENTITY Oxidation|nmod|Up-Regulation Up-Regulation|nmod|END_ENTITY	Propionate Promotes Fatty_Acid Oxidation through the Up-Regulation of Peroxisome_Proliferator-Activated_Receptor_a in Intestinal Epithelial Cells .
19617655	0	Propionate	0,10	VCAM-1	40,46	Propionate	VCAM-1	CHEBI:17272	7412	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	Propionate reduces the cytokine-induced VCAM-1 and ICAM-1 expression by inhibiting nuclear_factor-kappa_B -LRB- NF-kappaB -RRB- activation .
16444779	0	Propionate	0,10	insulin	36,43	Propionate	insulin	CHEBI:17272	3630	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|compound|END_ENTITY	Propionate inhibits glucose-induced insulin secretion in isolated rat pancreatic islets .
17917389	0	Propionate	0,10	insulin	47,54	Propionate	insulin	CHEBI:17272	280829(Tax:9913)	Chemical	Gene	test|amod|START_ENTITY test|nmod|determination determination|nmod|secretion secretion|compound|END_ENTITY	Propionate tolerance test for determination of insulin secretion in a hyperglycemic Japanese Black steer .
25600616	0	Propofol	0,8	ABCA1	36,41	Propofol	ABCA1	MESH:D015742	19	Chemical	Gene	START_ENTITY|dobj|expression expression|nmod|END_ENTITY	Propofol up-regulates expression of ABCA1 , ABCG1 , and SR-B1 through the PPARy/LXRa signaling pathway in THP-1 macrophage-derived foam cells .
25105067	0	Propofol	0,8	AKT	125,128	Propofol	AKT	MESH:D015742	207	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Propofol mediates signal_transducer_and_activator_of_transcription_3 activation and crosstalk with phosphoinositide_3-kinase / AKT .
23673104	0	Propofol	0,8	GSK-3b	92,98	Propofol	GSK-3b	MESH:D015742	84027(Tax:10116)	Chemical	Gene	protect|nsubj|START_ENTITY protect|nmod|END_ENTITY	Propofol may protect PC12 cells from b-amyloid induced apoptosis through the GSK-3b signaling pathway .
26956470	0	Propofol	0,8	HMGB1	127,132	Propofol	HMGB1	MESH:D015742	3146	Chemical	Gene	Rats|compound|START_ENTITY Rats|nmod|Expression Expression|compound|END_ENTITY	Propofol Protects Rats and Human Alveolar Epithelial Cells Against Lipopolysaccharide-Induced Acute_Lung_Injury via Inhibiting HMGB1 Expression .
23742776	0	Propofol	0,8	MMP-9	114,119	Propofol	MMP-9	MESH:D015742	4318	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|upregulating upregulating|dobj|expression expression|compound|END_ENTITY	Propofol inhibits the adhesion of hepatocellular_carcinoma cells by upregulating microRNA-199a and downregulating MMP-9 expression .
25605267	0	Propofol	10,18	MMP-9	40,45	Propofol	MMP-9	MESH:D015742	81687(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of Propofol on the Expression of MMP-9 and Its Relevant Inflammatory Factors in Brain of Rat with Intracerebral_Hemorrhage .
22901367	0	Propofol	0,8	Nrf2	94,98	Propofol	Nrf2	MESH:D015742	4780	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Propofol induces proliferation and invasion of gallbladder_cancer cells through activation of Nrf2 .
26171233	0	Propofol	0,8	TRPA1	42,47	Propofol	TRPA1	MESH:D015742	8989	Chemical	Gene	sensitivity|amod|START_ENTITY sensitivity|nmod|END_ENTITY	Propofol restores TRPV1 sensitivity via a TRPA1 - , nitric_oxide_synthase-dependent activation of PKC .
25695672	0	Propofol	0,8	Toll-Like_Receptor_4	97,117	Propofol	Toll-Like Receptor 4	MESH:D015742	7099	Chemical	Gene	Responses|compound|START_ENTITY Responses|nmod|Astrocytes Astrocytes|nmod|END_ENTITY	Propofol Inhibits Lipopolysaccharide-Induced Inflammatory Responses in Spinal Astrocytes via the Toll-Like_Receptor_4 / MyD88-Dependent Nuclear Factor-kB , Extracellular Signal-Regulated Protein Kinases1/2 , and p38_Mitogen-Activated_Protein_Kinase Pathways .
25695672	0	Propofol	0,8	Toll-Like_Receptor_4	97,117	Propofol	Toll-Like Receptor 4	MESH:D015742	7099	Chemical	Gene	Responses|compound|START_ENTITY Responses|nmod|Astrocytes Astrocytes|nmod|END_ENTITY	Propofol Inhibits Lipopolysaccharide-Induced Inflammatory Responses in Spinal Astrocytes via the Toll-Like_Receptor_4 / MyD88-Dependent Nuclear Factor-kB , Extracellular Signal-Regulated Protein Kinases1/2 , and p38_Mitogen-Activated_Protein_Kinase Pathways .
23684133	0	Propofol	0,8	Toll-like_receptor_4	104,124	Propofol	Toll-like receptor 4	MESH:D015742	7099	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|suppressing suppressing|dobj|pathway pathway|compound|END_ENTITY	Propofol inhibits hypoxia/reoxygenation-induced human gastric epithelial cell injury by suppressing the Toll-like_receptor_4 pathway .
26981881	0	Propofol	0,8	Toll-like_receptor_4	104,124	Propofol	Toll-like receptor 4	MESH:D015742	29260(Tax:10116)	Chemical	Gene	exerts|nsubj|START_ENTITY exerts|nmod|inhibition inhibition|nmod|kappa-light-chain-enhancer kappa-light-chain-enhancer|compound|END_ENTITY	Propofol , but not ketamine or midazolam , exerts neuroprotection after ischaemic_injury by inhibition of Toll-like_receptor_4 and nuclear factor kappa-light-chain-enhancer of activated B-cell signalling : A combined in vitro and animal study .
23095677	0	Propofol	0,8	angiotensin-converting_enzyme_2	19,50	Propofol	angiotensin-converting enzyme 2	MESH:D015742	59272	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Propofol increases angiotensin-converting_enzyme_2 expression in human pulmonary artery endothelial cells .
19020152	0	Propofol	0,8	aquaporin-4	33,44	Propofol	aquaporin-4	MESH:D015742	25293(Tax:10116)	Chemical	Gene	pretreatment|amod|START_ENTITY attenuates|nsubj|pretreatment attenuates|dobj|over-expression over-expression|amod|END_ENTITY	Propofol pretreatment attenuates aquaporin-4 over-expression and alleviates cerebral_edema after transient focal brain_ischemia reperfusion in rats .
19843787	0	Propofol	0,8	aquaporin_4	18,29	Propofol	aquaporin 4	MESH:D015742	25293(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Propofol inhibits aquaporin_4 expression through a protein kinase C-dependent pathway in an astrocyte model of cerebral_ischemia / reoxygenation .
23247820	0	Propofol	0,8	basic_fibroblast_growth_factor	33,63	Propofol	basic fibroblast growth factor	MESH:D015742	54250(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Propofol increases expression of basic_fibroblast_growth_factor after transient cerebral_ischemia in rats .
16879472	0	Propofol	0,8	c-Fos	71,76	Propofol	c-Fos	MESH:D015742	14281(Tax:10090)	Chemical	Gene	acts|nsubj|START_ENTITY acts|nmod|expression expression|amod|END_ENTITY	Propofol acts at the sigma-1_receptor and inhibits pentazocine-induced c-Fos expression in the mouse posterior cingulate and retrosplenial cortices .
19349923	0	Propofol	0,8	c-Fos	45,50	Propofol	c-Fos	MESH:D015742	2353	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Propofol induces ERK-dependant expression of c-Fos and Egr-1 in neuronal cells .
16861438	0	Propofol	0,8	c-fos	54,59	Propofol	c-fos	MESH:D015742	14281(Tax:10090)	Chemical	Gene	effects|nsubj|START_ENTITY effects|nmod|expression expression|compound|END_ENTITY	Propofol 's effects on nociceptive_behavior and spinal c-fos expression after intraplantar formalin injection in mice with a mutation in the gamma-aminobutyric_acid-type -LRB- A -RRB- receptor beta3 subunit .
9842840	0	Propofol	0,8	c-fos	35,40	Propofol	c-fos	MESH:D015742	314322(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Propofol inhibits ketamine-induced c-fos expression in the rat posterior cingulate cortex .
20637119	0	Propofol	0,8	cFos	58,62	Propofol	cFos	MESH:D015742	314322(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Propofol induces MAPK/ERK cascade dependant expression of cFos and Egr-1 in rat hippocampal slices .
16181106	0	Propofol	0,8	caspase-3	18,27	Propofol	caspase-3	MESH:D015742	836	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Propofol inhibits caspase-3 in astroglial cells : role of heme_oxygenase-1 .
22901676	0	Propofol	0,8	caspase-3	52,61	Propofol	caspase-3	MESH:D015742	836	Chemical	Gene	attenuate|nsubj|START_ENTITY attenuate|dobj|activation activation|amod|END_ENTITY	Propofol and magnesium attenuate isoflurane-induced caspase-3 activation via inhibiting mitochondrial permeability transition pore .
17898383	0	Propofol	0,8	endothelial_nitric_oxide_synthase	44,77	Propofol	endothelial nitric oxide synthase	MESH:D015742	4846	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|amod|END_ENTITY	Propofol reduces apoptosis and up-regulates endothelial_nitric_oxide_synthase protein expression in hydrogen_peroxide-stimulated human umbilical vein endothelial cells .
19687739	0	Propofol	0,8	endothelial_nitric_oxide_synthase	17,50	Propofol	endothelial nitric oxide synthase	MESH:D015742	4846	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|amod|END_ENTITY	Propofol induces endothelial_nitric_oxide_synthase phosphorylation and activation in human umbilical vein endothelial cells by inhibiting protein_kinase_C_delta expression .
21703615	0	Propofol	0,8	hypoxia-inducible_factor-1a	107,134	Propofol	hypoxia-inducible factor-1a	MESH:D015742	29560(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|nmod|END_ENTITY	Propofol attenuates hypoxia-induced apoptosis in alveolar_epithelial_type_II cells through down-regulating hypoxia-inducible_factor-1a .
16845912	0	Propofol	0,8	iNOS	34,38	Propofol	iNOS	MESH:D015742	18126(Tax:10090)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|END_ENTITY	Propofol significantly attenuates iNOS , CAT-2 , and CAT-2B transcription in lipopolysaccharide-stimulated murine macrophages .
19573522	0	Propofol	0,8	iNOS	44,48	Propofol	iNOS	MESH:D015742	4843	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Propofol inhibits lipoteichoic_acid-induced iNOS gene expression in macrophages possibly through downregulation of toll-like_receptor_2-mediated activation of Raf-MEK1 / 2-ERK1 / 2-IKK-NFkappaB .
15636717	0	Propofol	1,9	intercellular_adhesion_molecular-1	18,52	Propofol	intercellular adhesion molecular-1	MESH:D015742	25464(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|amod|END_ENTITY	-LSB- Propofol reduces intercellular_adhesion_molecular-1 expression in lung_injury following intestinal ischemia/reperfusion in rats -RSB- .
22164217	0	Propofol	0,8	p38	36,39	Propofol	p38	MESH:D015742	1432	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	Propofol inhibits the activation of p38 through up-regulating the expression of annexin_A1 to exert its anti-inflammation effect .
16879472	0	Propofol	0,8	sigma-1_receptor	21,37	Propofol	sigma-1 receptor	MESH:D015742	18391(Tax:10090)	Chemical	Gene	acts|nsubj|START_ENTITY acts|nmod|expression expression|amod|END_ENTITY	Propofol acts at the sigma-1_receptor and inhibits pentazocine-induced c-Fos expression in the mouse posterior cingulate and retrosplenial cortices .
19433076	0	Propofol	0,8	toll-like_receptor_4	173,193	Propofol	toll-like receptor 4	MESH:D015742	7099	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|downregulation downregulation|nmod|expression expression|amod|END_ENTITY	Propofol suppresses tumor_necrosis_factor-alpha biosynthesis in lipopolysaccharide-stimulated macrophages possibly through downregulation of nuclear_factor-kappa_B-mediated toll-like_receptor_4 gene expression .
24827783	0	Propofol	0,8	tumor_necrosis_factor-a	41,64	Propofol	tumor necrosis factor-a	MESH:D015742	24835(Tax:10116)	Chemical	Gene	anesthesia|compound|START_ENTITY induces|nsubj|anesthesia induces|dobj|END_ENTITY	Propofol anesthesia induces proapoptotic tumor_necrosis_factor-a and pro-nerve_growth_factor signaling and prosurvival Akt and XIAP expression in neonatal rat brain .
25312048	0	Propofol	0,8	tumor_necrosis_factor-a	32,55	Propofol	tumor necrosis factor-a	MESH:D015742	7124	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|amod|END_ENTITY	Propofol attenuates LPS-induced tumor_necrosis_factor-a , interleukin-6 and nitric_oxide expression in canine peripheral blood mononuclear cells possibly through down-regulation of nuclear factor -LRB- NF -RRB- - kB activation .
23528058	0	Propranolol	0,11	CD147	98,103	Propranolol	CD147	MESH:D011433	682	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|downregulation downregulation|nmod|END_ENTITY	Propranolol induces apoptosis of human umbilical vein endothelial cells through downregulation of CD147 .
9748542	0	Propranolol	0,11	Fos	43,46	Propranolol	Fos	MESH:D011433	314322(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|compound|END_ENTITY	Propranolol attenuates haloperidol-induced Fos expression in discrete regions of rat brain : possible brain regions responsible for akathisia .
21541209	0	Propranolol	58,69	Insulin	0,7	Propranolol	Insulin	MESH:D011433	100009181(Tax:9986)	Chemical	Gene	Toxicity|compound|START_ENTITY Model|nmod|Toxicity Emulsion|nmod|Model Emulsion|compound|END_ENTITY	Insulin versus Lipid Emulsion in a Rabbit Model of Severe Propranolol Toxicity : A Pilot Study .
22580939	0	Propranolol	0,11	VEGF-A	89,95	Propranolol	VEGF-A	MESH:D011433	7422	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|inhibition inhibition|nmod|END_ENTITY	Propranolol induces regression of hemangioma cells through HIF-1a-mediated inhibition of VEGF-A .
16150441	0	Propranolol	0,11	ether-a-go-go-related_gene	31,57	Propranolol	ether-a-go-go-related gene	MESH:D011433	2078	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|channels channels|amod|END_ENTITY	Propranolol inhibits the human ether-a-go-go-related_gene potassium channels .
940711	0	Propranolol	0,11	growth_hormone	49,63	Propranolol	growth hormone	MESH:D011433	2688	Chemical	Gene	START_ENTITY|nmod|deficiency deficiency|amod|END_ENTITY	Propranolol and exercise as a screening test for growth_hormone deficiency .
7051722	0	Propranolol	0,11	insulin	54,61	Propranolol	insulin	MESH:D011433	3630	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|secretion secretion|compound|END_ENTITY	Propranolol does not inhibit sulphonylurea-stimulated insulin secretion in patients with non-insulin_dependent_diabetes_mellitus .
11749856	0	Propranolol	0,11	phospholipase_D	64,79	Propranolol	phospholipase D	MESH:D011433	2822	Chemical	Gene	increases|amod|START_ENTITY phosphatidic_acid|nsubj|increases phosphatidic_acid|dobj|level level|nmod|activation activation|nmod|END_ENTITY	Propranolol increases phosphatidic_acid level via activation of phospholipase_D .
7457643	0	Propranolol	0,11	rage	32,36	Propranolol	rage	MESH:D011433	101669765	Chemical	Gene	START_ENTITY|nmod|treatment treatment|nmod|END_ENTITY	Propranolol in the treatment of rage and violent_behavior in patients with chronic brain_syndromes .
7020487	0	Propranolol	0,11	renin	19,24	Propranolol	renin	MESH:D011433	5972	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|release release|compound|END_ENTITY	Propranolol alters renin release during nitroprusside-induced hypotension and prevents hypertension on discontinuation of nitroprusside .
26991797	0	Propranolol	0,11	vascular_endothelial_growth_factor	55,89	Propranolol	vascular endothelial growth factor	MESH:D011433	7422	Chemical	Gene	START_ENTITY|dep|Effect Effect|nmod|END_ENTITY	Propranolol for infantile_hemangioma : Effect on plasma vascular_endothelial_growth_factor .
12114793	0	Propyithiouracil	11,27	Thyroglobulin	83,96	Propyithiouracil	Thyroglobulin	null	24826(Tax:10116)	Chemical	Gene	Administration|compound|START_ENTITY Administration|nmod|END_ENTITY	Effects of Propyithiouracil -LRB- PTU -RRB- Administration on the Synthesis and Secretion of Thyroglobulin in the Rat Thyroid Gland : A Quantitative Immuno-electron Microscopic Study Using Immunogold Technique .
17611791	0	Propylthiouracil	0,16	C-ANCA	25,31	Propylthiouracil	C-ANCA	MESH:D011441	5657	Chemical	Gene	induced|compound|START_ENTITY END_ENTITY|nsubj|induced	Propylthiouracil induced C-ANCA positive agranulocytosis complicating Graves ' thyrotoxicosis in pregnancy .
25556305	0	Prorenin	28,36	p65	70,73	Prorenin	p65	null	5970	Chemical	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	Indoxyl_Sulfate Upregulates Prorenin Expression via Nuclear Factor-kB p65 , Signal_Transducer_and_Activator_of_Transcription_3 , and Reactive Oxygen Species in Proximal Tubular Cells .
6756698	1	Prorenin	139,147	renin	168,173	Prorenin	renin	null	5972	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Prorenin as a determinant of renin secretion .
7813123	0	Prorenin	0,8	renin	20,25	Prorenin	renin	null	280909(Tax:9913)	Chemical	Gene	concentrations|amod|START_ENTITY concentrations|compound|END_ENTITY	Prorenin and active renin concentrations in ovarian follicular fluid increase after the LH peak in superovulated heifers .
9070702	0	Prorenin	0,8	renin	20,25	Prorenin	renin	null	5972	Chemical	Gene	concentrations|compound|START_ENTITY concentrations|compound|END_ENTITY	Prorenin and active renin concentrations in plasma and ascites during severe ovarian_hyperstimulation_syndrome .
26139576	0	Prostacyclin	0,12	PTGIR	23,28	Prostacyclin	PTGIR	MESH:D011464	5739	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Prostacyclin receptor -LRB- PTGIR -RRB- in the porcine endometrium : Regulation of expression and role in luminal epithelial and stromal cells .
26139576	0	Prostacyclin	0,12	PTGIR	23,28	Prostacyclin	PTGIR	MESH:D011464	5739	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Prostacyclin receptor -LRB- PTGIR -RRB- in the porcine endometrium : Regulation of expression and role in luminal epithelial and stromal cells .
18755267	0	Prostacyclin	0,12	STAT3	30,35	Prostacyclin	STAT3	MESH:D011464	6774	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|compound|END_ENTITY	Prostacyclin receptor-induced STAT3 phosphorylation in human_erythroleukemia cells is mediated via Galpha -LRB- s -RRB- and Galpha -LRB- 16 -RRB- hybrid signaling .
2656070	0	Prostacyclin	0,12	angiotensin_II	72,86	Prostacyclin	angiotensin II	MESH:D011464	183	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|nmod|END_ENTITY	Prostacyclin attenuates both the pressor and adrenocortical response to angiotensin_II in human pregnancy .
6998710	0	Prostacyclin	0,12	bradykinin	60,70	Prostacyclin	bradykinin	MESH:D011464	3827	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|dobj|effect effect|nmod|END_ENTITY	Prostacyclin mediates the potentiated hypotensive effect of bradykinin following captopril treatment .
3327542	0	Prostacyclin	0,12	relaxin	24,31	Prostacyclin	relaxin	MESH:D011464	396891(Tax:9823)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|compound|END_ENTITY	Prostacyclin stimulates relaxin release from cultured porcine luteal cells .
24003391	0	Prostaglandin	35,48	Cyclooxygenase-2	131,147	Prostaglandin	Cyclooxygenase-2	CHEBI:26333	5743	Chemical	Gene	Signaling|compound|START_ENTITY Heme_Oxygenase-1|nmod|Signaling Suppression|nmod|Heme_Oxygenase-1 Central|nsubj|Suppression Central|nmod|Expression Expression|compound|END_ENTITY	Suppression of Heme_Oxygenase-1 by Prostaglandin E2-Protein Kinase A-A-Kinase Anchoring Protein Signaling Is Central for Augmented Cyclooxygenase-2 Expression in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages .
26269890	0	Prostaglandin	23,36	DP1	40,43	Prostaglandin	DP1	CHEBI:26333	5729	Chemical	Gene	Receptor|compound|START_ENTITY Receptor|compound|END_ENTITY	Cytoprotective Role of Prostaglandin D2 DP1 Receptor against Neuronal_Injury Following Acute Excitotoxicity and Cerebral_Ischemia Each year , hundreds of thousands of people experience a new or recurrent stroke .
16707842	0	Prostaglandin	0,13	EP1	54,57	Prostaglandin	EP1	CHEBI:26333	25637(Tax:10116)	Chemical	Gene	facilitates|nsubj|START_ENTITY facilitates|dobj|activity activity|nmod|receptors receptors|nummod|END_ENTITY	Prostaglandin facilitates afferent nerve activity via EP1 receptors during urinary_bladder_inflammation in rats .
24003391	0	Prostaglandin	35,48	Heme_Oxygenase-1	15,31	Prostaglandin	Heme Oxygenase-1	CHEBI:26333	3162	Chemical	Gene	Signaling|compound|START_ENTITY END_ENTITY|nmod|Signaling	Suppression of Heme_Oxygenase-1 by Prostaglandin E2-Protein Kinase A-A-Kinase Anchoring Protein Signaling Is Central for Augmented Cyclooxygenase-2 Expression in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages .
26928462	0	Prostaglandin	64,77	LFA-1	47,52	Prostaglandin	LFA-1	CHEBI:26333	16408(Tax:10090)	Chemical	Gene	Inhibition|compound|START_ENTITY Inhibition|compound|END_ENTITY	IFNy-Dependent Interactions between ICAM-1 and LFA-1 Counteract Prostaglandin E2-Mediated Inhibition of Antitumor CTL Responses .
27030019	0	Prostaglandin	64,77	LFA-1	47,52	Prostaglandin	LFA-1	CHEBI:26333	16408(Tax:10090)	Chemical	Gene	Inhibition|compound|START_ENTITY Inhibition|compound|END_ENTITY	IFNy-Dependent Interactions between ICAM-1 and LFA-1 Counteract Prostaglandin E2-Mediated Inhibition of Antitumor CTL Responses .
26464663	0	Prostaglandin	0,13	SLCO2A1	27,34	Prostaglandin	SLCO2A1	CHEBI:26333	6578	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Prostaglandin transporter , SLCO2A1 , mediates the invasion and apoptosis of lung_cancer cells via PI3K/AKT/mTOR pathway .
26539716	0	Prostaglandin	77,90	SLCO2A1	52,59	Prostaglandin	SLCO2A1	CHEBI:26333	6578	Chemical	Gene	Transporter|compound|START_ENTITY Encoding|dobj|Transporter Caused|xcomp|Encoding Caused|nmod|Gene Gene|compound|END_ENTITY	A Hereditary Enteropathy Caused by Mutations in the SLCO2A1 Gene , Encoding a Prostaglandin Transporter .
15251468	0	Prostaglandin	0,13	alpha-melanocyte_stimulating_hormone	64,100	Prostaglandin	alpha-melanocyte stimulating hormone	CHEBI:26333	5443	Chemical	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Prostaglandin production by melanocytic cells and the effect of alpha-melanocyte_stimulating_hormone .
8894718	0	Prostaglandin	0,13	cyclooxygenase-2	42,58	Prostaglandin	cyclooxygenase-2	CHEBI:26333	5743	Chemical	Gene	production|compound|START_ENTITY production|nmod|induction induction|nmod|fibroblasts fibroblasts|amod|END_ENTITY	Prostaglandin production via induction of cyclooxygenase-2 by human gingival fibroblasts stimulated with lipopolysaccharides .
18710634	0	Prostaglandin	0,13	matrix_metalloproteinase-1	40,66	Prostaglandin	matrix metalloproteinase-1	CHEBI:26333	4312	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Prostaglandin induces the expression of matrix_metalloproteinase-1 in ciliary melanocytes .
6191362	0	Prostaglandin	0,13	ornithine_decarboxylase	29,52	Prostaglandin	ornithine decarboxylase	CHEBI:26333	18263(Tax:10090)	Chemical	Gene	stimulation|compound|START_ENTITY stimulation|nmod|activity activity|amod|END_ENTITY	Prostaglandin stimulation of ornithine_decarboxylase activity in mammary gland explants from mid-pregnant mice .
12091337	0	Prostaglandin-E2	0,16	STAT5	39,44	Prostaglandin-E2	STAT5	MESH:D015232	6776	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|compound|END_ENTITY	Prostaglandin-E2 enhances EPO-mediated STAT5 transcriptional activity by serine phosphorylation of CREB .
20720307	0	Prostaglandin-endoperoxide	0,26	COX1	42,46	Prostaglandin-endoperoxide	COX1	null	4512	Chemical	Gene	genes|amod|START_ENTITY genes|dep|END_ENTITY	Prostaglandin-endoperoxide synthase genes COX1 and COX2 - novel modifiers of disease severity in cystic_fibrosis patients .
11697817	0	Prostaglandin_A1	0,16	NF-kappaB	41,50	Prostaglandin A1	NF-kappaB	MESH:C100573	18033(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	Prostaglandin_A1 inhibits stress-induced NF-kappaB activation and reverses resistance to topoisomerase II inhibitors .
11026560	0	Prostaglandin_A1	0,16	c-fos	26,31	Prostaglandin A1	c-fos	MESH:C100573	2353	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Prostaglandin_A1 enhances c-fos expression and activating_protein-1 activity .
24900177	0	Prostaglandin_D	65,80	HPGDS	91,96	Prostaglandin D	HPGDS	null	101116145	Chemical	Gene	Synthase|compound|START_ENTITY Synthase|appos|END_ENTITY	Discovery of an Oral Potent Selective Inhibitor of Hematopoietic Prostaglandin_D Synthase -LRB- HPGDS -RRB- .
16227827	0	Prostaglandin_D2	0,16	CRTH2	68,73	Prostaglandin D2	CRTH2	MESH:D015230	11251	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|chemotaxis chemotaxis|nmod|eosinophils eosinophils|nmod|END_ENTITY	Prostaglandin_D2 induces chemotaxis in eosinophils via its receptor CRTH2 and eosinophils may cause severe ocular_inflammation in patients with allergic_conjunctivitis .
16888024	0	Prostaglandin_D2	0,16	CRTH2	90,95	Prostaglandin D2	CRTH2	MESH:D015230	14764(Tax:10090)	Chemical	Gene	plays|nsubj|START_ENTITY plays|dobj|role role|nmod|allergic_inflammation allergic_inflammation|nmod|skin skin|nmod|receptor receptor|compound|END_ENTITY	Prostaglandin_D2 plays an essential role in chronic allergic_inflammation of the skin via CRTH2 receptor .
22705147	0	Prostaglandin_D2	0,16	CRTH2	74,79	Prostaglandin D2	CRTH2	MESH:D015230	11251	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|activating activating|dobj|receptor receptor|compound|END_ENTITY	Prostaglandin_D2 induces apoptosis of human osteoclasts by activating the CRTH2 receptor and the intrinsic apoptosis pathway .
18957281	0	Prostaglandin_D2	0,16	DP2	70,73	Prostaglandin D2	DP2	MESH:D015230	7029	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|receptor receptor|compound|END_ENTITY	Prostaglandin_D2 induces heme_oxygenase-1 mRNA expression through the DP2 receptor .
16876988	0	Prostaglandin_D2	0,16	HSP27	48,53	Prostaglandin D2	HSP27	MESH:D015230	15507(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Prostaglandin_D2 induces the phosphorylation of HSP27 in osteoblasts : function of the MAP kinase superfamily .
18178816	0	Prostaglandin_D2	0,16	IFN-gamma	44,53	Prostaglandin D2	IFN-gamma	MESH:D015230	3458	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|nmod|END_ENTITY	Prostaglandin_D2 inhibits the production of IFN-gamma by invariant NK T cells : consequences in the control of B16 melanoma .
16940740	0	Prostaglandin_D2	0,16	IL-8	25,29	Prostaglandin D2	IL-8	MESH:D015230	3576	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Prostaglandin_D2 induces IL-8 and GM-CSF by bronchial epithelial cells in a CRTH2-independent pathway .
19925780	0	Prostaglandin_D2	0,16	beta-defensin-3	49,64	Prostaglandin D2	beta-defensin-3	MESH:D015230	55894	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|nmod|END_ENTITY	Prostaglandin_D2 induces the production of human beta-defensin-3 in human keratinocytes .
19617658	0	Prostaglandin_D2	0,16	hematopoietic_prostaglandin_D_synthase	29,67	Prostaglandin D2	hematopoietic prostaglandin D synthase	MESH:D015230	58962(Tax:10116)	Chemical	Gene	START_ENTITY|acl|produced produced|nmod|END_ENTITY	Prostaglandin_D2 produced by hematopoietic_prostaglandin_D_synthase contributes to LPS-induced fever .
18174022	0	Prostaglandin_D2	0,16	heme_oxygenase-1	25,41	Prostaglandin D2	heme oxygenase-1	MESH:D015230	3162	Chemical	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Prostaglandin_D2 induces heme_oxygenase-1 in human retinal pigment epithelial cells .
18957281	0	Prostaglandin_D2	0,16	heme_oxygenase-1	25,41	Prostaglandin D2	heme oxygenase-1	MESH:D015230	3162	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Prostaglandin_D2 induces heme_oxygenase-1 mRNA expression through the DP2 receptor .
10582659	0	Prostaglandin_D2	0,16	interleukin-6	25,38	Prostaglandin D2	interleukin-6	MESH:D015230	16193(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|synthesis synthesis|amod|END_ENTITY	Prostaglandin_D2 induces interleukin-6 synthesis via Ca2 + mobilization in osteoblasts : regulation by protein_kinase_C .
6591147	0	Prostaglandin_D2	0,16	vasoactive_intestinal_polypeptide	28,61	Prostaglandin D2	vasoactive intestinal polypeptide	MESH:D015230	117064(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|amod|END_ENTITY	Prostaglandin_D2 stimulates vasoactive_intestinal_polypeptide release into rat hypophysial portal blood .
22844123	0	Prostaglandin_E	0,15	Axl	94,97	Prostaglandin E	Axl	null	558	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|pathway pathway|compound|END_ENTITY	Prostaglandin_E induces oncostatin_M expression in human chronic wound macrophages through Axl receptor_tyrosine_kinase pathway .
25001909	0	Prostaglandin_E	0,15	CD25	52,56	Prostaglandin E	CD25	null	281861(Tax:9913)	Chemical	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|nmod|END_ENTITY	Prostaglandin_E down-regulates the expression of CD25 on bovine T cells , and this effect is mediated through the EP4 receptor .
16051640	0	Prostaglandin_E	0,15	EP3	25,28	Prostaglandin E	EP3	null	19218(Tax:10090)	Chemical	Gene	deficiency|amod|START_ENTITY deficiency|compound|END_ENTITY	Prostaglandin_E receptor EP3 deficiency modifies tumor outcome in mouse two-stage skin_carcinogenesis .
8939915	0	Prostaglandin_E	0,15	EP3	25,28	Prostaglandin E	EP3	null	24929(Tax:10116)	Chemical	Gene	subtype|amod|START_ENTITY subtype|compound|END_ENTITY	Prostaglandin_E receptor EP3 subtype induces neurite retraction via small GTPase Rho .
9231874	0	Prostaglandin_E	0,15	EP3	25,28	Prostaglandin E	EP3	null	24929(Tax:10116)	Chemical	Gene	subtype|amod|START_ENTITY subtype|compound|END_ENTITY	Prostaglandin_E receptor EP3 subtype is involved in thermal hyperalgesia through its actions in the preoptic_hypothalamus and the diagonal band of Broca in rats .
19303430	0	Prostaglandin_E	0,15	EP4	33,36	Prostaglandin E	EP4	null	19219(Tax:10090)	Chemical	Gene	agonist|compound|START_ENTITY agonist|compound|END_ENTITY	Prostaglandin_E receptor subtype EP4 agonist protects cochleae against noise-induced trauma .
20890108	0	Prostaglandin_E	41,56	S100p	17,22	Prostaglandin E	S100p	null	6285	Chemical	Gene	induction|nmod|START_ENTITY induction|nmod|expression expression|amod|END_ENTITY	The induction of S100p expression by the Prostaglandin_E -LRB- PGE -RRB- / EP4 receptor signaling pathway in colon_cancer cells .
23525457	0	Prostaglandin_E	0,15	focal_adhesion_kinase	60,81	Prostaglandin E	focal adhesion kinase	null	14083(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Prostaglandin_E receptor EP1-mediated phosphorylation of focal_adhesion_kinase enhances cell adhesion and migration in hepatocellular_carcinoma cells .
6977613	0	Prostaglandin_E	0,15	interleukin_2	49,62	Prostaglandin E	interleukin 2	null	3558	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|nmod|END_ENTITY	Prostaglandin_E inhibits the production of human interleukin_2 .
22844123	0	Prostaglandin_E	0,15	oncostatin_M	27,39	Prostaglandin E	oncostatin M	null	5008	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Prostaglandin_E induces oncostatin_M expression in human chronic wound macrophages through Axl receptor_tyrosine_kinase pathway .
22844123	0	Prostaglandin_E	0,15	receptor_tyrosine_kinase	98,122	Prostaglandin E	receptor tyrosine kinase	null	5979	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|pathway pathway|amod|END_ENTITY	Prostaglandin_E induces oncostatin_M expression in human chronic wound macrophages through Axl receptor_tyrosine_kinase pathway .
18271757	0	Prostaglandin_E1	0,16	MCP-1	39,44	Prostaglandin E1	MCP-1	MESH:D000527	6347	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Prostaglandin_E1 inhibits IL-6-induced MCP-1 expression by interfering specifically in IL-6-dependent ERK1/2 , but not STAT3 , activation .
3830160	0	Prostaglandin_E1	0,16	Z_protein	26,35	Prostaglandin E1	Z protein	MESH:D000527	24360(Tax:10116)	Chemical	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Prostaglandin_E1 binds to Z_protein of rat liver .
8263051	0	Prostaglandin_E1	0,16	c-Fos	25,30	Prostaglandin E1	c-Fos	MESH:D000527	314322(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Prostaglandin_E1 induces c-Fos and Myc proteins and protects rat hippocampal cells against hypoxic_injury .
10645515	0	Prostaglandin_E1	0,16	cholesterol_esterase	34,54	Prostaglandin E1	cholesterol esterase	MESH:D000527	1056	Chemical	Gene	influences|nsubj|START_ENTITY influences|dobj|END_ENTITY	Prostaglandin_E1 influences serum cholesterol_esterase and lipase activity in different ways .
9067638	0	Prostaglandin_E1	0,16	interleukin-6	28,41	Prostaglandin E1	interleukin-6	MESH:D000527	16193(Tax:10090)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|amod|END_ENTITY	Prostaglandin_E1 stimulates interleukin-6 secretion via protein kinase A in osteoblast-like cells .
8793799	0	Prostaglandin_E1	0,16	monocyte-chemoattractant_protein_1	59,93	Prostaglandin E1	monocyte-chemoattractant protein 1	MESH:D000527	24770(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|nmod|END_ENTITY	Prostaglandin_E1 reduces the glomerular mRNA expression of monocyte-chemoattractant_protein_1 in anti-thymocyte antibody-induced glomerular_injury .
9570453	0	Prostaglandin_E1	0,16	tumor_necrosis_factor-alpha	28,55	Prostaglandin E1	tumor necrosis factor-alpha	MESH:D000527	7124	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|production production|amod|END_ENTITY	Prostaglandin_E1 suppresses tumor_necrosis_factor-alpha and interleukin-10 production by lipopolysaccharides-stimulated mononuclear cells .
12960284	0	Prostaglandin_E2	0,16	CCL3	68,72	Prostaglandin E2	CCL3	MESH:D015232	6348	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|nmod|END_ENTITY	Prostaglandin_E2 inhibits production of the inflammatory chemokines CCL3 and CCL4 in dendritic cells .
16837093	0	Prostaglandin_E2	0,16	COX-2	42,47	Prostaglandin E2	COX-2	MESH:D015232	19225(Tax:10090)	Chemical	Gene	START_ENTITY|acl|produced produced|nmod|END_ENTITY	Prostaglandin_E2 produced by late induced COX-2 stimulates hippocampal neuron loss after seizure in the CA3 region .
26020725	0	Prostaglandin_E2	36,52	COX-2	30,35	Prostaglandin E2	COX-2	MESH:D015232	17709(Tax:10090)	Chemical	Gene	Axis|compound|START_ENTITY Regulates|dep|Axis Regulates|dep|END_ENTITY	The Tpl2 Kinase Regulates the COX-2 / Prostaglandin_E2 Axis in Adipocytes in Inflammatory Conditions .
20093341	0	Prostaglandin_E2	0,16	CYP1B1	25,31	Prostaglandin E2	CYP1B1	MESH:D015232	1545	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nummod|END_ENTITY	Prostaglandin_E2 induces CYP1B1 expression via ligand-independent activation of the ERalpha pathway in human breast_cancer cells .
25898207	0	Prostaglandin_E2	124,140	Cyclooxygenase-2	107,123	Prostaglandin E2	Cyclooxygenase-2	MESH:D015232	5743	Chemical	Gene	Up-Regulation|nsubj|START_ENTITY Apoptosis|parataxis|Up-Regulation Apoptosis|nmod|END_ENTITY	Advanced Glycation End-Products Induce Apoptosis in Pancreatic Islet Endothelial Cells via NF-kB-Activated Cyclooxygenase-2 / Prostaglandin_E2 Up-Regulation .
26280673	0	Prostaglandin_E2	45,61	Cyclooxygenase_2	18,34	Prostaglandin E2	Cyclooxygenase 2	MESH:D015232	5743	Chemical	Gene	Synthesis|compound|START_ENTITY Synthesis|compound|END_ENTITY	Vitamin_D Induces Cyclooxygenase_2 Dependent Prostaglandin_E2 Synthesis in HaCaT keratinocytes .
26280673	0	Prostaglandin_E2	45,61	Cyclooxygenase_2	18,34	Prostaglandin E2	Cyclooxygenase 2	MESH:D015232	5743	Chemical	Gene	Synthesis|compound|START_ENTITY Synthesis|compound|END_ENTITY	Vitamin_D Induces Cyclooxygenase_2 Dependent Prostaglandin_E2 Synthesis in HaCaT keratinocytes .
14623033	0	Prostaglandin_E2	0,16	EP1	88,91	Prostaglandin E2	EP1	MESH:D015232	25637(Tax:10116)	Chemical	Gene	aggravates|compound|START_ENTITY induced|nsubj|aggravates induced|nmod|receptors receptors|nummod|END_ENTITY	Prostaglandin_E2 aggravates gastric_mucosal_injury induced by histamine in rats through EP1 receptors .
17551669	0	Prostaglandin_E2	0,16	EP1	121,124	Prostaglandin E2	EP1	MESH:D015232	5731	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|parataxis|signaling signaling|nsubj|involvement involvement|nmod|receptors receptors|compound|END_ENTITY	Prostaglandin_E2 enhances mitogen-activated protein kinase/Erk pathway in human cholangiocarcinoma cells : involvement of EP1 receptor , calcium and EGF receptors signaling .
18032663	0	Prostaglandin_E2	0,16	EP1	25,28	Prostaglandin E2	EP1	MESH:D015232	19216(Tax:10090)	Chemical	Gene	acts|amod|START_ENTITY acts|nmod|receptor receptor|compound|END_ENTITY	Prostaglandin_E2 acts on EP1 receptor and amplifies both dopamine D1 and D2_receptor signaling in the striatum .
18648368	0	Prostaglandin_E2	0,16	EP1	58,61	Prostaglandin E2	EP1	MESH:D015232	5731	Chemical	Gene	stimulates|amod|START_ENTITY Fas_ligand|nsubj|stimulates Fas_ligand|dobj|expression expression|nmod|receptor receptor|compound|END_ENTITY	Prostaglandin_E2 stimulates Fas_ligand expression via the EP1 receptor in colon_cancer cells .
20035770	0	Prostaglandin_E2	0,16	EP1	57,60	Prostaglandin E2	EP1	MESH:D015232	5731	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|nmod|receptor receptor|compound|END_ENTITY	Prostaglandin_E2 upregulates survivin expression via the EP1 receptor in hepatocellular_carcinoma cells .
21342756	0	Prostaglandin_E2	0,16	EP1	98,101	Prostaglandin E2	EP1	MESH:D015232	25637(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|proliferation proliferation|nmod|receptor receptor|compound|END_ENTITY	Prostaglandin_E2 increases cardiac fibroblast proliferation and increases cyclin D expression via EP1 receptor .
25289898	0	Prostaglandin_E2	0,16	EP1	91,94	Prostaglandin E2	EP1	MESH:D015232	5731	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|pathway pathway|compound|END_ENTITY	Prostaglandin_E2 stimulates b1-integrin expression in hepatocellular_carcinoma through the EP1 receptor/PKC/NF-kB pathway .
26004410	0	Prostaglandin_E2	116,132	EP1	133,136	Prostaglandin E2	EP1	MESH:D015232	19216(Tax:10090)	Chemical	Gene	Receptor|compound|START_ENTITY Receptor|compound|END_ENTITY	Regulatory Mechanism of the Gastric Hyperemic Response Following Barrier Disruption : Roles of Cyclooxygenase-1 , the Prostaglandin_E2 / EP1 Receptor and Sensory Neurons .
9365020	0	Prostaglandin_E2	0,16	EP1	49,52	Prostaglandin E2	EP1	MESH:D015232	25637(Tax:10116)	Chemical	Gene	induce|nsubj|START_ENTITY induce|nmod|receptor receptor|nummod|END_ENTITY	Prostaglandin_E2 may induce hyperthermia through EP1 receptor in the anterior wall of the third ventricle and neighboring preoptic regions .
9504958	0	Prostaglandin_E2	0,16	EP1	61,64	Prostaglandin E2	EP1	MESH:D015232	19216(Tax:10090)	Chemical	Gene	autoamplifies|nsubj|START_ENTITY autoamplifies|nmod|subtype subtype|nummod|END_ENTITY	Prostaglandin_E2 -LRB- PGE2 -RRB- autoamplifies its production through EP1 subtype of PGE receptor in mouse osteoblastic MC3T3-E1 cells .
10466584	0	Prostaglandin_E2	0,16	EP2	105,108	Prostaglandin E2	EP2	MESH:D015232	5732	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|nmod|receptors receptors|nummod|END_ENTITY	Prostaglandin_E2 downregulates interferon-gamma-induced intercellular_adhesion_molecule-1 expression via EP2 receptors in human_gingival_fibroblasts .
15234114	0	Prostaglandin_E2	0,16	EP2	84,87	Prostaglandin E2	EP2	MESH:D015232	5732	Chemical	Gene	induced|nsubj|START_ENTITY induced|nmod|activation activation|nmod|receptors receptors|nummod|END_ENTITY	Prostaglandin_E2 induced caspase-dependent apoptosis possibly through activation of EP2 receptors in cultured hippocampal neurons .
15481309	0	Prostaglandin_E2	0,16	EP2	122,125	Prostaglandin E2	EP2	MESH:D015232	81752(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|subtype subtype|compound|END_ENTITY	Prostaglandin_E2 inhibits platelet-derived growth factor-stimulated cell proliferation through a prostaglandin_E receptor EP2 subtype in rat hepatic stellate cells .
16309709	0	Prostaglandin_E2	0,16	EP2	105,108	Prostaglandin E2	EP2	MESH:D015232	81752(Tax:10116)	Chemical	Gene	deteriorates|nsubj|START_ENTITY deteriorates|advcl|activating activating|dobj|receptors receptors|nummod|END_ENTITY	Prostaglandin_E2 deteriorates N-methyl-D-aspartate receptor-mediated cytotoxicity possibly by activating EP2 receptors in cultured cortical neurons .
16432506	0	Prostaglandin_E2	0,16	EP2	27,30	Prostaglandin E2	EP2	MESH:D015232	5732	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|receptors receptors|compound|END_ENTITY	Prostaglandin_E2 activates EP2 receptors to inhibit human lung mast cell degranulation .
16886605	0	Prostaglandin_E2	0,16	EP2	37,40	Prostaglandin E2	EP2	MESH:D015232	19217(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY subtype|nsubj|receptor subtype|dobj|2 2|appos|END_ENTITY	Prostaglandin_E2 receptor subtype 2 -LRB- EP2 -RRB- null mice are protected against murine lung_tumorigenesis .
17075575	0	Prostaglandin_E2	0,16	EP2	77,80	Prostaglandin E2	EP2	MESH:D015232	19217(Tax:10090)	Chemical	Gene	required|nsubjpass|START_ENTITY required|nmod|skin_inflammation skin_inflammation|nmod|receptors receptors|compound|END_ENTITY	Prostaglandin_E2 is required for ultraviolet B-induced skin_inflammation via EP2 and EP4 receptors .
17427962	0	Prostaglandin_E2	0,16	EP2	103,106	Prostaglandin E2	EP2	MESH:D015232	5732	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|pathway pathway|compound|END_ENTITY	Prostaglandin_E2 induces vascular_endothelial_growth_factor secretion in prostate_cancer cells through EP2 receptor-mediated cAMP pathway .
20551148	0	Prostaglandin_E2	0,16	EP2	34,37	Prostaglandin E2	EP2	MESH:D015232	5732	Chemical	Gene	receptor|amod|START_ENTITY subtype|nsubj|receptor subtype|dobj|expression expression|amod|END_ENTITY	Prostaglandin_E2 receptor subtype EP2 - and EP4-regulated gene expression profiling in human ciliary smooth muscle cells .
21945767	0	Prostaglandin_E2	1,17	EP2	79,82	Prostaglandin E2	EP2	MESH:D015232	5732	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|-RSB- -RSB-|nummod|END_ENTITY	-LSB- Prostaglandin_E2 promotes hepatocellular_carcinoma cell proliferation through EP2 prostanoid receptor -RSB- .
22475642	0	Prostaglandin_E2	0,16	EP2	73,76	Prostaglandin E2	EP2	MESH:D015232	5732	Chemical	Gene	suppresses|nummod|START_ENTITY poly|nmod:npmod|suppresses I|amod|poly I|dep|production production|nmod|END_ENTITY	Prostaglandin_E2 suppresses poly I : C-stimulated cytokine production via EP2 and EP3 in immortalized human corneal epithelial cells .
22517618	0	Prostaglandin_E2	0,16	EP2	132,135	Prostaglandin E2	EP2	MESH:D015232	5732	Chemical	Gene	represses|nsubj|START_ENTITY represses|nmod|receptors receptors|compound|END_ENTITY	Prostaglandin_E2 represses interleukin_1_beta-induced inflammatory mediator output from pregnant human myometrial cells through the EP2 and EP4 receptors .
24471568	0	Prostaglandin_E2	0,16	EP2	68,71	Prostaglandin E2	EP2	MESH:D015232	5732	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|mechanisms mechanisms|nummod|END_ENTITY	Prostaglandin_E2 regulates its own inactivating enzyme , 15-PGDH , by EP2 receptor-mediated cervical cell-specific mechanisms .
25329458	0	Prostaglandin_E2	0,16	EP2	103,106	Prostaglandin E2	EP2	MESH:D015232	5732	Chemical	Gene	Prevents|nsubj|START_ENTITY Prevents|nmod|END_ENTITY	Prostaglandin_E2 Prevents Hyperosmolar-Induced Human Mast Cell Activation through Prostanoid Receptors EP2 and EP4 .
9348184	0	Prostaglandin_E2	0,16	EP2	34,37	Prostaglandin E2	EP2	MESH:D015232	19217(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY expression|nummod|END_ENTITY	Prostaglandin_E2 receptor subtype EP2 gene expression in the mouse uterus coincides with differentiation of the luminal epithelium for implantation .
21896757	0	Prostaglandin_E2	0,16	EP2_receptor	106,118	Prostaglandin E2	EP2 receptor	MESH:D015232	19217(Tax:10090)	Chemical	Gene	release|amod|START_ENTITY triggers|nsubj|release triggers|dobj|firing firing|nmod|activation activation|amod|END_ENTITY	Prostaglandin_E2 release from astrocytes triggers gonadotropin-releasing_hormone -LRB- GnRH -RRB- neuron firing via EP2_receptor activation .
11997037	0	Prostaglandin_E2	0,16	EP3	98,101	Prostaglandin E2	EP3	MESH:D015232	5733	Chemical	Gene	reinforces|nsubj|START_ENTITY reinforces|nmod|cells cells|nmod|END_ENTITY	Prostaglandin_E2 reinforces the activation of Ras signal pathway in lung_adenocarcinoma cells via EP3 .
16081678	0	Prostaglandin_E2	0,16	EP3	56,59	Prostaglandin E2	EP3	MESH:D015232	5733	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|nmod|receptor receptor|nummod|END_ENTITY	Prostaglandin_E2 enhances neurotrophin-4 production via EP3 receptor in human keratinocytes .
18292084	0	Prostaglandin_E2	0,16	EP3	71,74	Prostaglandin E2	EP3	MESH:D015232	24929(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|nmod|receptors receptors|nmod|receptors receptors|nummod|END_ENTITY	Prostaglandin_E2 attenuates preoptic expression of GABAA receptors via EP3 receptors .
19239477	0	Prostaglandin_E2	0,16	EP3	75,78	Prostaglandin E2	EP3	MESH:D015232	24929(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|activating activating|dobj|receptors receptors|compound|END_ENTITY	Prostaglandin_E2 induces contraction of liver myofibroblasts by activating EP3 and FP prostanoid receptors .
23349487	0	Prostaglandin_E2	0,16	EP3	27,30	Prostaglandin E2	EP3	MESH:D015232	19218(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Prostaglandin_E2 receptor , EP3 , is induced in diabetic islets and negatively regulates glucose - and hormone-stimulated insulin secretion .
26632188	0	Prostaglandin_E2	33,49	EP3	50,53	Prostaglandin E2	EP3	MESH:D015232	19218(Tax:10090)	Chemical	Gene	Isoform|compound|START_ENTITY Isoform|compound|END_ENTITY	Characterization of Motor Neuron Prostaglandin_E2 EP3 Receptor Isoform in a Mouse Model of Amyotrophic_Lateral_Sclerosis .
26718710	0	Prostaglandin_E2	5,21	EP3	0,3	Prostaglandin E2	EP3	MESH:D015232	24929(Tax:10116)	Chemical	Gene	Subtype|compound|START_ENTITY END_ENTITY|appos|Subtype	EP3 , Prostaglandin_E2 Receptor Subtype 3 , Associated with Neuronal Apoptosis Following Intracerebral_Hemorrhage .
12215436	0	Prostaglandin_E2	0,16	EP4	82,85	Prostaglandin E2	EP4	MESH:D015232	5734	Chemical	Gene	suppresses|amod|START_ENTITY chemokine|nsubj|suppresses chemokine|nmod|receptor receptor|compound|END_ENTITY	Prostaglandin_E2 suppresses chemokine production in human macrophages through the EP4 receptor .
12566441	0	Prostaglandin_E2	0,16	EP4	84,87	Prostaglandin E2	EP4	MESH:D015232	5734	Chemical	Gene	induced|nummod|START_ENTITY functional|nmod:npmod|induced expression|amod|functional expression|nmod|early_growth_response_factor-1 early_growth_response_factor-1|nmod|END_ENTITY	Prostaglandin_E2 induced functional expression of early_growth_response_factor-1 by EP4 , but not EP2 , prostanoid receptors via the phosphatidylinositol 3-kinase and extracellular signal-regulated kinases .
12753465	0	Prostaglandin_E2	0,16	EP4	65,68	Prostaglandin E2	EP4	MESH:D015232	5734	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|nmod|receptors receptors|nummod|END_ENTITY	Prostaglandin_E2 downregulates interleukin-12 production through EP4 receptors in human monocytes stimulated with lipopolysaccharide from Actinobacillus_actinomycetemcomitans and interferon-gamma .
12853415	0	Prostaglandin_E2	0,16	EP4	60,63	Prostaglandin E2	EP4	MESH:D015232	84023(Tax:10116)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|system system|nmod|receptor receptor|compound|END_ENTITY	Prostaglandin_E2 activates the histaminergic system via the EP4 receptor to induce wakefulness in rats .
15123528	0	Prostaglandin_E2	0,16	EP4	94,97	Prostaglandin E2	EP4	MESH:D015232	19219(Tax:10090)	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|injury injury|nmod|END_ENTITY	Prostaglandin_E2 protects the heart from ischemia-reperfusion injury via its receptor subtype EP4 .
15193540	0	Prostaglandin_E2	0,16	EP4	27,30	Prostaglandin E2	EP4	MESH:D015232	84023(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Prostaglandin_E2 receptor -LRB- EP4 -RRB- selective agonist -LRB- ONO-4819 .
16515909	0	Prostaglandin_E2	0,16	EP4	17,20	Prostaglandin E2	EP4	MESH:D015232	84023(Tax:10116)	Chemical	Gene	agonist|compound|START_ENTITY agonist|compound|END_ENTITY	Prostaglandin_E2 EP4 receptor-selective agonist facilitates sternal healing after harvesting bilateral internal thoracic arteries in diabetic rats .
17943254	0	Prostaglandin_E2	0,16	EP4	87,90	Prostaglandin E2	EP4	MESH:D015232	84023(Tax:10116)	Chemical	Gene	stimulates|amod|START_ENTITY VEGF|nsubj|stimulates VEGF|nmod|receptors receptors|nummod|END_ENTITY	Prostaglandin_E2 stimulates VEGF expression in primary rat gastric fibroblasts through EP4 receptors .
18802112	0	Prostaglandin_E2	0,16	EP4	102,105	Prostaglandin E2	EP4	MESH:D015232	5734	Chemical	Gene	exerts|nummod|START_ENTITY catabolic|nmod:npmod|exerts effects|amod|catabolic effects|dep|evidence evidence|acl|signaling signaling|nmod|receptor receptor|compound|END_ENTITY	Prostaglandin_E2 exerts catabolic effects in osteoarthritis cartilage : evidence for signaling via the EP4 receptor .
19176380	0	Prostaglandin_E2	0,16	EP4	125,128	Prostaglandin E2	EP4	MESH:D015232	5734	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|parataxis|involvement involvement|nmod|END_ENTITY	Prostaglandin_E2 stimulates human lung_carcinoma cell growth through induction of integrin-linked_kinase : the involvement of EP4 and Sp1 .
20205862	0	Prostaglandin_E2	0,16	EP4	134,137	Prostaglandin E2	EP4	MESH:D015232	5734	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|chondrocytes chondrocytes|nmod|receptor receptor|compound|END_ENTITY	Prostaglandin_E2 regulates the expression of connective tissue growth factor -LRB- CTGF/CCN2 -RRB- in human osteoarthritic chondrocytes via the EP4 receptor .
21832044	0	Prostaglandin_E2	0,16	EP4	69,72	Prostaglandin E2	EP4	MESH:D015232	5734	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|pathway pathway|compound|END_ENTITY	Prostaglandin_E2 regulates renal_cell_carcinoma invasion through the EP4 receptor-Rap GTPase signal transduction pathway .
22503965	0	Prostaglandin_E2	0,16	EP4	49,52	Prostaglandin E2	EP4	MESH:D015232	5734	Chemical	Gene	stimulates|amod|START_ENTITY cystogenesis|nsubj|stimulates cystogenesis|nmod|receptor receptor|nummod|END_ENTITY	Prostaglandin_E2 stimulates cystogenesis through EP4 receptor in IMCD-3 cells .
23090667	0	Prostaglandin_E2	0,16	EP4	69,72	Prostaglandin E2	EP4	MESH:D015232	5734	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|receptor receptor|compound|END_ENTITY	Prostaglandin_E2 regulates pancreatic stellate cell activity via the EP4 receptor .
23265688	0	Prostaglandin_E2	0,16	EP4	17,20	Prostaglandin E2	EP4	MESH:D015232	5734	Chemical	Gene	START_ENTITY|parataxis|signalling signalling|nsubj|END_ENTITY	Prostaglandin_E2 / EP4 signalling facilitates EP4 receptor externalization in primary sensory neurons in vitro and in vivo .
23265688	0	Prostaglandin_E2	0,16	EP4	44,47	Prostaglandin E2	EP4	MESH:D015232	5734	Chemical	Gene	START_ENTITY|parataxis|signalling signalling|dobj|externalization externalization|compound|END_ENTITY	Prostaglandin_E2 / EP4 signalling facilitates EP4 receptor externalization in primary sensory neurons in vitro and in vivo .
24146253	0	Prostaglandin_E2	0,16	EP4	69,72	Prostaglandin E2	EP4	MESH:D015232	5734	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|elastogenesis elastogenesis|nmod|arteriosus arteriosus|nmod|signaling signaling|compound|END_ENTITY	Prostaglandin_E2 inhibits elastogenesis in the ductus arteriosus via EP4 signaling .
25109834	0	Prostaglandin_E2	0,16	EP4	134,137	Prostaglandin E2	EP4	MESH:D015232	5734	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|advcl|upregulating upregulating|dobj|expression expression|nmod|receptor receptor|nummod|END_ENTITY	Prostaglandin_E2 promotes the cell growth and invasive ability of hepatocellular carcinoma cells by upregulating c-Myc expression via EP4 receptor and the PKA signaling pathway .
25785867	0	Prostaglandin_E2	0,16	EP4	73,76	Prostaglandin E2	EP4	MESH:D015232	19219(Tax:10090)	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|proliferation proliferation|nmod|myoblasts myoblasts|nmod|activation activation|compound|END_ENTITY	Prostaglandin_E2 promotes proliferation of skeletal muscle myoblasts via EP4 receptor activation .
25917098	0	Prostaglandin_E2	0,16	EP4	64,67	Prostaglandin E2	EP4	MESH:D015232	5734	Chemical	Gene	Activation|compound|START_ENTITY Activation|nmod|Receptor Receptor|compound|END_ENTITY	Prostaglandin_E2 Inhibits NLRP3 Inflammasome Activation through EP4 Receptor and Intracellular Cyclic_AMP in Human Macrophages .
8908618	0	Prostaglandin_E2	0,16	EP4	107,110	Prostaglandin E2	EP4	MESH:D015232	5734	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|cyclase cyclase|dep|comparison comparison|nmod|effects effects|nmod|END_ENTITY	Prostaglandin_E2 both stimulates and inhibits adenyl cyclase on platelets : comparison of effects on cloned EP4 and EP3 prostaglandin receptor subtypes .
19539567	0	Prostaglandin_E2	0,16	E_prostanoid_receptor_2	35,58	Prostaglandin E2	E prostanoid receptor 2	MESH:D015232	5732	Chemical	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Prostaglandin_E2 signaling through E_prostanoid_receptor_2 impairs proliferative response of double negative regulatory T cells .
8848429	0	Prostaglandin_E2	0,16	Egr-1	25,30	Prostaglandin E2	Egr-1	MESH:D015232	13653(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|mRNA mRNA|compound|END_ENTITY	Prostaglandin_E2 induces Egr-1 mRNA in MC3T3-E1 osteoblastic cells by a protein kinase C-dependent pathway .
16034085	0	Prostaglandin_E2	0,16	FOXP3	25,30	Prostaglandin E2	FOXP3	MESH:D015232	50943	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Prostaglandin_E2 induces FOXP3 gene expression and T regulatory cell function in human CD4 + T cells .
18648368	0	Prostaglandin_E2	0,16	Fas_ligand	28,38	Prostaglandin E2	Fas ligand	MESH:D015232	356	Chemical	Gene	stimulates|amod|START_ENTITY END_ENTITY|nsubj|stimulates	Prostaglandin_E2 stimulates Fas_ligand expression via the EP1 receptor in colon_cancer cells .
20018632	0	Prostaglandin_E2	0,16	IFN-alpha	26,35	Prostaglandin E2	IFN-alpha	MESH:D015232	3439	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|amod|END_ENTITY	Prostaglandin_E2 inhibits IFN-alpha secretion and Th1 costimulation by human plasmacytoid dendritic cells via E-prostanoid 2 and E-prostanoid 4 receptor engagement .
18250418	0	Prostaglandin_E2	0,16	IFN-beta	58,66	Prostaglandin E2	IFN-beta	MESH:D015232	15977(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|production production|amod|END_ENTITY	Prostaglandin_E2 suppresses lipopolysaccharide-stimulated IFN-beta production .
10232394	0	Prostaglandin_E2	0,16	IL-10	77,82	Prostaglandin E2	IL-10	MESH:D015232	25325(Tax:10116)	Chemical	Gene	down-regulation|amod|START_ENTITY independent|nsubj|down-regulation independent|nmod|END_ENTITY	Prostaglandin_E2 down-regulation of T cell IL-2 production is independent of IL-10 during gram-negative sepsis .
16818766	0	Prostaglandin_E2	0,16	IL-10	26,31	Prostaglandin E2	IL-10	MESH:D015232	3586	Chemical	Gene	augments|nsubj|START_ENTITY augments|dobj|signaling signaling|compound|END_ENTITY	Prostaglandin_E2 augments IL-10 signaling and function .
23359497	0	Prostaglandin_E2	0,16	IL-10	59,64	Prostaglandin E2	IL-10	MESH:D015232	3586	Chemical	Gene	potentiates|amod|START_ENTITY stem|nsubj|potentiates stem|ccomp|+ +|nsubj|CD4 CD4|compound|END_ENTITY	Prostaglandin_E2 potentiates mesenchymal stem cell-induced IL-10 + IFN-y + CD4 + regulatory T cells to control transplant_arteriosclerosis .
25286662	0	Prostaglandin_E2	0,16	IL-10	26,31	Prostaglandin E2	IL-10	MESH:D015232	281246(Tax:9913)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	Prostaglandin_E2 inhibits IL-10 production by bovine CD4 + T cells .
17371964	0	Prostaglandin_E2	0,16	IL-1alpha	43,52	Prostaglandin E2	IL-1alpha	MESH:D015232	3552	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Prostaglandin_E2 induces the expression of IL-1alpha in colon_cancer cells .
1374102	0	Prostaglandin_E2	0,16	IL-2	64,68	Prostaglandin E2	IL-2	MESH:D015232	3558	Chemical	Gene	modulate|nsubj|START_ENTITY modulate|dobj|expression expression|amod|END_ENTITY	Prostaglandin_E2 and other cyclic_AMP-elevating agents modulate IL-2 and IL-2R_alpha gene expression at multiple levels .
15180965	0	Prostaglandin_E2	0,16	IL-23	25,30	Prostaglandin E2	IL-23	MESH:D015232	51561	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|compound|END_ENTITY	Prostaglandin_E2 induces IL-23 production in bone marrow-derived dendritic cells .
22982753	0	Prostaglandin_E2	0,16	IL-23	26,31	Prostaglandin E2	IL-23	MESH:D015232	51561	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Prostaglandin_E2 inhibits IL-23 and IL-12 production by human monocytes through down-regulation of their common p40 subunit .
9500757	0	Prostaglandin_E2	0,16	IL-5	42,46	Prostaglandin E2	IL-5	MESH:D015232	3567	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Prostaglandin_E2 differentially modulates IL-5 gene expression in activated human T lymphocytes depending on the costimulatory signal .
22531917	0	Prostaglandin_E2	0,16	IL-8	27,31	Prostaglandin E2	IL-8	MESH:D015232	3576	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|compound|END_ENTITY	Prostaglandin_E2 modulates IL-8 expression through formation of a multiprotein enhanceosome in human colonic epithelial cells .
9759900	0	Prostaglandin_E2	0,16	IL-8	28,32	Prostaglandin E2	IL-8	MESH:D015232	3576	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	Prostaglandin_E2 stimulates IL-8 gene expression in human colonic epithelial cells by a posttranscriptional mechanism .
16275896	0	Prostaglandin_E2	0,16	MCP-1	63,68	Prostaglandin E2	MCP-1	MESH:D015232	6347	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|release release|nmod|END_ENTITY	Prostaglandin_E2 promotes degranulation-independent release of MCP-1 from mast cells .
24953041	0	Prostaglandin_E2	0,16	MSK1	72,76	Prostaglandin E2	MSK1	MESH:D015232	9252	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Prostaglandin_E2 induces retinoic_acid_receptor-b up-regulation through MSK1 .
15615708	0	Prostaglandin_E2	0,16	MUC8	25,29	Prostaglandin E2	MUC8	MESH:D015232	100129528	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Prostaglandin_E2 induces MUC8 gene expression via a mechanism involving ERK MAPK/RSK1/cAMP response element binding protein activation in human airway epithelial cells .
25917098	0	Prostaglandin_E2	0,16	NLRP3	26,31	Prostaglandin E2	NLRP3	MESH:D015232	114548	Chemical	Gene	Activation|compound|START_ENTITY Activation|compound|END_ENTITY	Prostaglandin_E2 Inhibits NLRP3 Inflammasome Activation through EP4 Receptor and Intracellular Cyclic_AMP in Human Macrophages .
16293616	0	Prostaglandin_E2	0,16	NR4A2	48,53	Prostaglandin E2	NR4A2	MESH:D015232	18227(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Prostaglandin_E2 regulates the nuclear receptor NR4A2 in colorectal_cancer .
10919613	0	Prostaglandin_E2	0,16	P-selectin	39,49	Prostaglandin E2	P-selectin	MESH:D015232	6403	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Prostaglandin_E2 induces expression of P-selectin -LRB- CD62P -RRB- on cultured human umbilical vein endothelial cells and enhances endothelial binding of CD4-T-cells .
21436889	0	Prostaglandin_E2	0,16	PTGER2	33,39	Prostaglandin E2	PTGER2	MESH:D015232	81752(Tax:10116)	Chemical	Gene	signals|nsubj|START_ENTITY signals|nmod|END_ENTITY	Prostaglandin_E2 signals through PTGER2 to regulate sclerostin expression .
25297547	0	Prostaglandin_E2	17,33	PTGES	44,49	Prostaglandin E2	PTGES	MESH:D015232	480698(Tax:9615)	Chemical	Gene	Synthase|compound|START_ENTITY Synthase|appos|END_ENTITY	Canine Placental Prostaglandin_E2 Synthase -LRB- PTGES -RRB- : Expression , Localization , and Biological Functions in Providing Substrates for Prepartum PGF2alpha Synthesis .
19464664	0	Prostaglandin_E2	0,16	Rap1	27,31	Prostaglandin E2	Rap1	MESH:D015232	5906	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Prostaglandin_E2 activates Rap1 via EP2/EP4 receptors and cAMP-signaling in rheumatoid synovial fibroblasts : involvement of Epac1 and PKA .
22728165	0	Prostaglandin_E2	0,16	S100A8	28,34	Prostaglandin E2	S100A8	MESH:D015232	6279	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	Prostaglandin_E2 stimulates S100A8 expression by activating protein kinase A and CCAAT/enhancer-binding-protein - beta in prostate_cancer cells .
19542367	0	Prostaglandin_E2	0,16	TNF-alpha	84,93	Prostaglandin E2	TNF-alpha	MESH:D015232	7124	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|effects effects|nmod|END_ENTITY	Prostaglandin_E2 differentially modulates proinflammatory/prodestructive effects of TNF-alpha on synovial fibroblasts via specific E prostanoid receptors/cAMP .
24601788	0	Prostaglandin_E2	0,16	Toll-like_receptor_4	25,45	Prostaglandin E2	Toll-like receptor 4	MESH:D015232	29260(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|compound|END_ENTITY	Prostaglandin_E2 reduces Toll-like_receptor_4 expression in alveolar macrophages by inhibition of translation .
17943254	0	Prostaglandin_E2	0,16	VEGF	28,32	Prostaglandin E2	VEGF	MESH:D015232	83785(Tax:10116)	Chemical	Gene	stimulates|amod|START_ENTITY END_ENTITY|nsubj|stimulates	Prostaglandin_E2 stimulates VEGF expression in primary rat gastric fibroblasts through EP4 receptors .
26926362	0	Prostaglandin_E2	0,16	Vascular_Endothelial_Growth_Factor	59,93	Prostaglandin E2	Vascular Endothelial Growth Factor	MESH:D015232	7422	Chemical	Gene	possesses|nsubj|START_ENTITY possesses|advcl|inducing inducing|dobj|production production|compound|END_ENTITY	Prostaglandin_E2 possesses different potencies in inducing Vascular_Endothelial_Growth_Factor and Interleukin-8 production in COPD human lung fibroblasts .
24802754	0	Prostaglandin_E2	0,16	a-smooth_muscle_actin	26,47	Prostaglandin E2	a-smooth muscle actin	MESH:D015232	58	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|transcription transcription|amod|END_ENTITY	Prostaglandin_E2 inhibits a-smooth_muscle_actin transcription during myofibroblast differentiation via distinct mechanisms of modulation of serum_response_factor and myocardin-related_transcription_factor-A .
15193769	0	Prostaglandin_E2	0,16	amyloid_precursor_protein	27,52	Prostaglandin E2	amyloid precursor protein	MESH:D015232	54226(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Prostaglandin_E2 regulates amyloid_precursor_protein expression via the EP2 receptor in cultured rat microglia .
6948521	0	Prostaglandin_E2	0,16	angiotensin_II	52,66	Prostaglandin E2	angiotensin II	MESH:D015232	183	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|nmod|END_ENTITY	Prostaglandin_E2 attenuates the pressor response to angiotensin_II in pregnant subjects but not in nonpregnant subjects .
990638	0	Prostaglandin_E2	0,16	angiotensin_II	127,141	Prostaglandin E2	angiotensin II	MESH:D015232	24179(Tax:10116)	Chemical	Gene	contributes|nsubj|START_ENTITY contributes|nmod|END_ENTITY	Prostaglandin_E2 released from the kidneys of genetic hypertensive rats contributes to the vasoconstrictor supersensitivity to angiotensin_II in vitro -LSB- proceedings -RSB- .
15280380	0	Prostaglandin_E2	0,16	beta-catenin	88,100	Prostaglandin E2	beta-catenin	MESH:D015232	1499	Chemical	Gene	antagonizes|nsubj|START_ENTITY antagonizes|dobj|END_ENTITY	Prostaglandin_E2 selectively antagonizes prostaglandin_F2alpha-stimulated T-cell_factor / beta-catenin signaling pathway by the FPB prostanoid receptor .
20403585	0	Prostaglandin_E2	0,16	beta1-integrin	28,42	Prostaglandin E2	beta1-integrin	MESH:D015232	3688	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Prostaglandin_E2 suppresses beta1-integrin expression via E-prostanoid receptor in human monocytes/macrophages .
12766167	0	Prostaglandin_E2	0,16	bone_sialoprotein	28,45	Prostaglandin E2	bone sialoprotein	MESH:D015232	24477(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Prostaglandin_E2 stimulates bone_sialoprotein -LRB- BSP -RRB- expression through cAMP and fibroblast_growth_factor_2 response elements in the proximal promoter of the rat BSP gene .
15963707	0	Prostaglandin_E2	0,16	cyclooxygenase-2	95,111	Prostaglandin E2	cyclooxygenase-2	MESH:D015232	5743	Chemical	Gene	production|amod|START_ENTITY regulated|nsubjpass|production regulated|xcomp|END_ENTITY	Prostaglandin_E2 production in ovarian_cancer cell lines is regulated by cyclooxygenase-1 , not cyclooxygenase-2 .
16256948	0	Prostaglandin_E2	0,16	cyclooxygenase-2	25,41	Prostaglandin E2	cyclooxygenase-2	MESH:D015232	5743	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Prostaglandin_E2 induces cyclooxygenase-2 expression in human non-pigmented ciliary epithelial cells through activation of p38 and p42/44 mitogen-activated protein kinases .
16319525	0	Prostaglandin_E2	0,16	cyclooxygenase-2	24,40	Prostaglandin E2	cyclooxygenase-2	MESH:D015232	5743	Chemical	Gene	drives|nsubj|START_ENTITY drives|dobj|expression expression|amod|END_ENTITY	Prostaglandin_E2 drives cyclooxygenase-2 expression via cyclic_AMP response element activation in human pancreatic_cancer cells .
17097802	0	Prostaglandin_E2	0,16	cyp19	27,32	Prostaglandin E2	cyp19	MESH:D015232	25147(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Prostaglandin_E2 increases cyp19 expression in rat granulosa cells : implication of GATA-4 .
16982695	0	Prostaglandin_E2	0,16	fibroblast_growth_factor_9	25,51	Prostaglandin E2	fibroblast growth factor 9	MESH:D015232	2254	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Prostaglandin_E2 induces fibroblast_growth_factor_9 via EP3-dependent protein kinase Cdelta and Elk-1 signaling .
9237220	0	Prostaglandin_E2	0,16	inhibin_alpha	25,38	Prostaglandin E2	inhibin alpha	MESH:D015232	3623	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Prostaglandin_E2 induces inhibin_alpha - and beta A-subunit mRNA and secretion of dimeric inhibin_A in cultured human granulosa-luteal cells .
8396006	0	Prostaglandin_E2	0,16	insulin-like_growth_factor-I	36,64	Prostaglandin E2	insulin-like growth factor-I	MESH:D015232	24482(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Prostaglandin_E2 rapidly stimulates insulin-like_growth_factor-I gene expression in primary rat osteoblast cultures : evidence for transcriptional control .
1645254	0	Prostaglandin_E2	0,16	insulin-like_growth_factor_I	28,56	Prostaglandin E2	insulin-like growth factor I	MESH:D015232	24482(Tax:10116)	Chemical	Gene	stimulates|amod|START_ENTITY END_ENTITY|nsubj|stimulates	Prostaglandin_E2 stimulates insulin-like_growth_factor_I synthesis in osteoblast-enriched cultures from fetal rat bone .
10207838	0	Prostaglandin_E2	0,16	intercellular_adhesion_molecule-1	33,66	Prostaglandin E2	intercellular adhesion molecule-1	MESH:D015232	3383	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|amod|END_ENTITY	Prostaglandin_E2 and I2 regulate intercellular_adhesion_molecule-1 expression in interleukin-1_beta-stimulated human_gingival_fibroblasts .
10466584	0	Prostaglandin_E2	0,16	intercellular_adhesion_molecule-1	56,89	Prostaglandin E2	intercellular adhesion molecule-1	MESH:D015232	3383	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	Prostaglandin_E2 downregulates interferon-gamma-induced intercellular_adhesion_molecule-1 expression via EP2 receptors in human_gingival_fibroblasts .
10357877	0	Prostaglandin_E2	0,16	interferon-gamma	32,48	Prostaglandin E2	interferon-gamma	MESH:D015232	15978(Tax:10090)	Chemical	Gene	enhancement|amod|START_ENTITY enhancement|nmod|production production|amod|END_ENTITY	Prostaglandin_E2 enhancement of interferon-gamma production by antigen-stimulated type 1 helper T cells .
2522938	0	Prostaglandin_E2	0,16	interferon_gamma	39,55	Prostaglandin E2	interferon gamma	MESH:D015232	3458	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Prostaglandin_E2 selectively increases interferon_gamma receptor expression on human CD8 + lymphocytes .
6331926	0	Prostaglandin_E2	0,16	interleukin-1	62,75	Prostaglandin E2	interleukin-1	MESH:D015232	3552	Chemical	Gene	depresses|nsubj|START_ENTITY depresses|advcl|inhibiting inhibiting|dobj|production production|amod|END_ENTITY	Prostaglandin_E2 depresses natural cytotoxicity by inhibiting interleukin-1 production by large granular lymphocytes .
8908620	0	Prostaglandin_E2	0,16	interleukin-1	55,68	Prostaglandin E2	interleukin-1	MESH:D015232	3552	Chemical	Gene	production|amod|START_ENTITY production|nmod|secretion secretion|nmod|END_ENTITY	Prostaglandin_E2 production by endogenous secretion of interleukin-1 in decidual cells obtained before and after the labor .
7877083	0	Prostaglandin_E2	0,16	interleukin-1_beta	120,138	Prostaglandin E2	interleukin-1 beta	MESH:D015232	3553	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|human_gingival_fibroblasts human_gingival_fibroblasts|acl|stimulated stimulated|nmod|END_ENTITY	Prostaglandin_E2 inhibits interleukin-6 release but not its transcription in human_gingival_fibroblasts stimulated with interleukin-1_beta or tumor_necrosis_factor-alpha .
8302918	0	Prostaglandin_E2	0,16	interleukin-1_beta	77,95	Prostaglandin E2	interleukin-1 beta	MESH:D015232	3553	Chemical	Gene	antagonizes|nsubj|START_ENTITY antagonizes|dobj|proliferation proliferation|acl|stimulated stimulated|advcl|END_ENTITY	Prostaglandin_E2 antagonizes gingival fibroblast proliferation stimulated by interleukin-1_beta .
8841895	0	Prostaglandin_E2	0,16	interleukin-1_beta	29,47	Prostaglandin E2	interleukin-1 beta	MESH:D015232	3553	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|production production|amod|END_ENTITY	Prostaglandin_E2 potentiates interleukin-1_beta induced interleukin-6 production by human_gingival_fibroblasts .
11453112	0	Prostaglandin_E2	0,16	interleukin-1beta	66,83	Prostaglandin E2	interleukin-1beta	MESH:D015232	3553	Chemical	Gene	secretion|amod|START_ENTITY secretion|nmod|fibroblasts fibroblasts|acl|treated treated|advcl|END_ENTITY	Prostaglandin_E2 secretion from gingival fibroblasts treated with interleukin-1beta : effects of lipid extracts from Porphyromonas_gingivalis or calculus .
9933502	0	Prostaglandin_E2	0,16	interleukin-1beta	66,83	Prostaglandin E2	interleukin-1beta	MESH:D015232	24494(Tax:10116)	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Prostaglandin_E2 mediates activation of hypothalamic histamine by interleukin-1beta in rats .
8964085	0	Prostaglandin_E2	0,16	interleukin-2	30,43	Prostaglandin E2	interleukin-2	MESH:D015232	3558	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	Prostaglandin_E2 inhibits the interleukin-2 promoter activity through down-regulation of the Oct-dependent transcription of the octamer motif .
9472935	0	Prostaglandin_E2	0,16	interleukin-2	32,45	Prostaglandin E2	interleukin-2	MESH:D015232	280822(Tax:9913)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Prostaglandin_E2 regulates both interleukin-2 and granulocyte-macrophage_colony-stimulating_factor gene expression in bovine lymphocytes .
20457835	0	Prostaglandin_E2	0,16	interleukin-6	25,38	Prostaglandin E2	interleukin-6	MESH:D015232	3569	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Prostaglandin_E2 induces interleukin-6 expression in human chondrocytes via cAMP/protein kinase A - and phosphatidylinositol 3-kinase-dependent NF-kappaB activation .
23490068	0	Prostaglandin_E2	0,16	interleukin-6	74,87	Prostaglandin E2	interleukin-6	MESH:D015232	3569	Chemical	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Prostaglandin_E2 induces transcription of skeletal muscle mass regulators interleukin-6 and muscle RING finger-1 in humans .
7877083	0	Prostaglandin_E2	0,16	interleukin-6	26,39	Prostaglandin E2	interleukin-6	MESH:D015232	3569	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|amod|END_ENTITY	Prostaglandin_E2 inhibits interleukin-6 release but not its transcription in human_gingival_fibroblasts stimulated with interleukin-1_beta or tumor_necrosis_factor-alpha .
8061551	0	Prostaglandin_E2	0,16	interleukin-6	46,59	Prostaglandin E2	interleukin-6	MESH:D015232	16193(Tax:10090)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|nmod|bones bones|amod|END_ENTITY	Prostaglandin_E2 stimulates the production of interleukin-6 by neonatal mouse parietal bones .
8841895	0	Prostaglandin_E2	0,16	interleukin-6	56,69	Prostaglandin E2	interleukin-6	MESH:D015232	3569	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|production production|amod|END_ENTITY	Prostaglandin_E2 potentiates interleukin-1_beta induced interleukin-6 production by human_gingival_fibroblasts .
9003059	0	Prostaglandin_E2	0,16	interleukin-6	25,38	Prostaglandin E2	interleukin-6	MESH:D015232	3569	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|synthesis synthesis|amod|END_ENTITY	Prostaglandin_E2 induces interleukin-6 synthesis in human astrocytoma cells .
22080750	0	Prostaglandin_E2	0,16	interleukin-8	26,39	Prostaglandin E2	interleukin-8	MESH:D015232	3576	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|amod|END_ENTITY	Prostaglandin_E2 enhances interleukin-8 production via EP4 receptor in human pulmonary microvascular endothelial cells .
2989362	0	Prostaglandin_E2	0,16	interleukin_2	89,102	Prostaglandin E2	interleukin 2	MESH:D015232	3558	Chemical	Gene	acts|amod|START_ENTITY acts|dep|inhibition inhibition|nmod|production production|amod|END_ENTITY	Prostaglandin_E2 acts at two distinct pathways of T lymphocyte activation : inhibition of interleukin_2 production and down-regulation of transferrin_receptor expression .
7693857	0	Prostaglandin_E2	0,16	interleukin_2	63,76	Prostaglandin E2	interleukin 2	MESH:D015232	3558	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|transcription transcription|amod|END_ENTITY	Prostaglandin_E2 and other cyclic_AMP elevating agents inhibit interleukin_2 gene transcription by counteracting calcineurin-dependent pathways .
8660843	0	Prostaglandin_E2	0,16	interleukin_2	65,78	Prostaglandin E2	interleukin 2	MESH:D015232	3558	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|transcription transcription|nmod|END_ENTITY	Prostaglandin_E2 inhibits the nuclear transcription of the human interleukin_2 , but not the Il-4 , gene in human T cells by targeting transcription factors AP-1 and NF-AT .
26310818	0	Prostaglandin_E2	0,16	mTORC1	31,37	Prostaglandin E2	mTORC1	MESH:D015232	382056(Tax:10090)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|pathway pathway|amod|END_ENTITY	Prostaglandin_E2 activates the mTORC1 pathway through an EP4/cAMP/PKA and EP1/Ca2 + - mediated mechanism in the human pancreatic_carcinoma cell line PANC-1 .
10395955	0	Prostaglandin_E2	0,16	macrophage_colony_stimulating_factor	27,63	Prostaglandin E2	macrophage colony stimulating factor	MESH:D015232	1435	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|secretion secretion|compound|END_ENTITY	Prostaglandin_E2 regulates macrophage_colony_stimulating_factor secretion by human bone marrow stromal cells .
9083277	0	Prostaglandin_E2	0,16	matrix_metalloproteinase_2	42,68	Prostaglandin E2	matrix metalloproteinase 2	MESH:D015232	81686(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|nmod|END_ENTITY	Prostaglandin_E2 stimulates expression of matrix_metalloproteinase_2 in cultured rat mesangial cells .
21940623	0	Prostaglandin_E2	0,16	matrix_metalloproteinase_9	25,51	Prostaglandin E2	matrix metalloproteinase 9	MESH:D015232	4318	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Prostaglandin_E2 induces matrix_metalloproteinase_9 expression in dendritic cells through two independent signaling pathways leading to activator_protein_1 -LRB- AP-1 -RRB- activation .
11123707	0	Prostaglandin_E2	0,16	motilin	28,35	Prostaglandin E2	motilin	MESH:D015232	481748(Tax:9615)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|compound|END_ENTITY	Prostaglandin_E2 stimulates motilin release via a cholinergic muscarinic pathway in the dog .
12788827	0	Prostaglandin_E2	0,16	neurokinin1_receptor	49,69	Prostaglandin E2	neurokinin1 receptor	MESH:D015232	24807(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Prostaglandin_E2 increases the expression of the neurokinin1_receptor in adult sensory neurones in culture : a novel role of prostaglandins .
16081678	0	Prostaglandin_E2	0,16	neurotrophin-4	26,40	Prostaglandin E2	neurotrophin-4	MESH:D015232	4909	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|amod|END_ENTITY	Prostaglandin_E2 enhances neurotrophin-4 production via EP3 receptor in human keratinocytes .
12097485	0	Prostaglandin_E2	0,16	oncostatin-M	39,51	Prostaglandin E2	oncostatin-M	MESH:D015232	5008	Chemical	Gene	inducer|nsubj|START_ENTITY inducer|nmod|expression expression|amod|END_ENTITY	Prostaglandin_E2 is a novel inducer of oncostatin-M expression in macrophages and microglia .
16256948	0	Prostaglandin_E2	0,16	p38	123,126	Prostaglandin E2	p38	MESH:D015232	1432	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Prostaglandin_E2 induces cyclooxygenase-2 expression in human non-pigmented ciliary epithelial cells through activation of p38 and p42/44 mitogen-activated protein kinases .
8590973	0	Prostaglandin_E2	0,16	phospholipase_A2	108,124	Prostaglandin E2	phospholipase A2	MESH:D015232	151056	Chemical	Gene	requirement|amod|START_ENTITY requirement|nmod|inhibition inhibition|nmod|END_ENTITY	Prostaglandin_E2 requirement for transforming_growth_factor_beta_1 inhibition of elicited macrophage 14 kDa phospholipase_A2 release .
9757037	0	Prostaglandin_E2	0,16	proenkephalin	27,40	Prostaglandin E2	proenkephalin	MESH:D015232	29237(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|level level|compound|END_ENTITY	Prostaglandin_E2 increases proenkephalin mRNA level in rat astrocyte-enriched culture .
16504491	0	Prostaglandin_E2	0,16	transforming_growth_factor-beta_1	26,59	Prostaglandin E2	transforming growth factor-beta 1	MESH:D015232	59086(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|synthesis synthesis|amod|END_ENTITY	Prostaglandin_E2 enhances transforming_growth_factor-beta_1 and TGF-beta receptors synthesis : an in vivo and in vitro study .
3162731	0	Prostaglandin_E2	0,16	tumor_necrosis_factor	46,67	Prostaglandin E2	tumor necrosis factor	MESH:D015232	21926(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Prostaglandin_E2 regulates macrophage-derived tumor_necrosis_factor gene expression .
1548034	0	Prostaglandin_E2	0,16	tumor_necrosis_factor-alpha	41,68	Prostaglandin E2	tumor necrosis factor-alpha	MESH:D015232	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|nmod|END_ENTITY	Prostaglandin_E2 inhibits the release of tumor_necrosis_factor-alpha , rather than interleukin_1_beta , from human macrophages .
18060853	0	Prostaglandin_E2	0,16	tumor_necrosis_factor-alpha	26,53	Prostaglandin E2	tumor necrosis factor-alpha	MESH:D015232	7124	Chemical	Gene	RNA|compound|START_ENTITY RNA|compound|END_ENTITY	Prostaglandin_E2 inhibits tumor_necrosis_factor-alpha RNA through PKA type I. Tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- is a cytokine that may contribute to the pathogenesis of septic_shock , rheumatoid_arthritis , cancer , and diabetes .
14707101	0	Prostaglandin_E2	0,16	vascular_endothelial_growth_factor	65,99	Prostaglandin E2	vascular endothelial growth factor	MESH:D015232	7422	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|nmod|END_ENTITY	Prostaglandin_E2 induces degranulation-independent production of vascular_endothelial_growth_factor by human mast cells .
17427962	0	Prostaglandin_E2	0,16	vascular_endothelial_growth_factor	25,59	Prostaglandin E2	vascular endothelial growth factor	MESH:D015232	7422	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|secretion secretion|compound|END_ENTITY	Prostaglandin_E2 induces vascular_endothelial_growth_factor secretion in prostate_cancer cells through EP2 receptor-mediated cAMP pathway .
22298530	0	Prostaglandin_E2	0,16	vascular_endothelial_growth_factor	46,80	Prostaglandin E2	vascular endothelial growth factor	MESH:D015232	7422	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|nmod|END_ENTITY	Prostaglandin_E2 stimulates the production of vascular_endothelial_growth_factor through the E-prostanoid-2 receptor in cultured human lung fibroblasts .
24898841	0	Prostaglandin_E2	0,16	vascular_endothelial_growth_factor	43,77	Prostaglandin E2	vascular endothelial growth factor	MESH:D015232	443103(Tax:9940)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Prostaglandin_E2 regulation of amnion cell vascular_endothelial_growth_factor expression : relationship with intramembranous absorption rate in fetal sheep .
9501870	0	Prostaglandin_E2	0,16	vascular_endothelial_growth_factor	25,59	Prostaglandin E2	vascular endothelial growth factor	MESH:D015232	83785(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Prostaglandin_E2 induces vascular_endothelial_growth_factor and basic_fibroblast_growth_factor mRNA expression in cultured rat M ller cells .
3457882	0	Prostaglandin_E_and_thromboxane_B2	0,34	C3b	84,87	Prostaglandin E and thromboxane B2	C3b	null	718	Chemical	Gene	release|nsubj|START_ENTITY release|nmod|END_ENTITY	Prostaglandin_E_and_thromboxane_B2 release by PMA-induced U937 cells in response to C3b .
9071991	0	Prostaglandin_F2_alpha	0,22	endothelin-1	57,69	Prostaglandin F2 alpha	endothelin-1	MESH:D015237	281137(Tax:9913)	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|action action|nmod|END_ENTITY	Prostaglandin_F2_alpha promotes the inhibitory action of endothelin-1 on the bovine luteal function in vitro .
7530723	0	Prostaglandin_F2_alpha	0,22	insulin-like_growth_factor_binding_protein-3	45,89	Prostaglandin F2 alpha	insulin-like growth factor binding protein-3	MESH:D015237	3486	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|nmod|END_ENTITY	Prostaglandin_F2_alpha stimulates release of insulin-like_growth_factor_binding_protein-3 from cultured human granulosa-luteal cells .
7628355	0	Prostaglandin_F2_alpha	0,22	transforming_growth_factor-alpha	34,66	Prostaglandin F2 alpha	transforming growth factor-alpha	MESH:D015237	7124	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Prostaglandin_F2_alpha stimulates transforming_growth_factor-alpha expression in adipocyte precursors .
20826536	0	Prostaglandin_F2a	0,17	PTGS2	37,42	Prostaglandin F2a	PTGS2	CHEBI:15553	29527(Tax:10116)	Chemical	Gene	stimulates|amod|START_ENTITY END_ENTITY|nsubj|stimulates	Prostaglandin_F2a -LRB- PGF2a -RRB- stimulates PTGS2 expression and PGF2a synthesis through NFKB activation via reactive oxygen species in the corpus luteum of pseudopregnant rats .
25614048	0	Prostaglandin_F2a	0,17	activating_transcription_factor_3	40,73	Prostaglandin F2a	activating transcription factor 3	CHEBI:15553	25389(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Prostaglandin_F2a induces expression of activating_transcription_factor_3 -LRB- ATF3 -RRB- and activates MAPK signaling in the rat corpus luteum .
9730948	0	Prostaglandin_F2alpha	0,21	CFTR	33,37	Prostaglandin F2alpha	CFTR	MESH:D015237	12638(Tax:10090)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|amod|END_ENTITY	Prostaglandin_F2alpha stimulates CFTR activity by PKA - and PKC-dependent phosphorylation .
18612190	0	Prostaglandin_F2alpha	0,21	Egr-1	81,86	Prostaglandin F2alpha	Egr-1	MESH:D015237	24330(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|induction induction|nmod|END_ENTITY	Prostaglandin_F2alpha inhibits SERCA2 gene transcription through an induction of Egr-1 in cultured neonatal rat cardiac myocytes .
14709331	0	Prostaglandin_F2alpha	0,21	GLUT1	88,93	Prostaglandin F2alpha	GLUT1	MESH:D015237	6513	Chemical	Gene	increases|nsubj|START_ENTITY increases|nmod|expression expression|compound|END_ENTITY	Prostaglandin_F2alpha increases glucose transport in 3T3-L1 adipocytes through enhanced GLUT1 expression by a protein_kinase_C-dependent pathway .
15094384	0	Prostaglandin_F2alpha	0,21	tumor_necrosis_factor-alpha	32,59	Prostaglandin F2alpha	tumor necrosis factor-alpha	MESH:D015237	7124	Chemical	Gene	amplifies|nsubj|START_ENTITY amplifies|dobj|activity activity|amod|END_ENTITY	Prostaglandin_F2alpha amplifies tumor_necrosis_factor-alpha promoter activity by the FPB prostanoid receptor .
25140003	0	Prostaglandin_Glycerol_Esters	21,50	Monoacylglycerol_Lipase	60,83	Prostaglandin Glycerol Esters	Monoacylglycerol Lipase	null	11343	Chemical	Gene	Hydrolysis|nmod|START_ENTITY Hydrolysis|nmod|END_ENTITY	Robust Hydrolysis of Prostaglandin_Glycerol_Esters by Human Monoacylglycerol_Lipase -LRB- MAGL -RRB- .
21955608	0	Prostaglandin_I2	0,16	Fas_ligand	55,65	Prostaglandin I2	Fas ligand	MESH:D011464	356	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|apoptosis apoptosis|nmod|upregulation upregulation|nmod|END_ENTITY	Prostaglandin_I2 induces apoptosis via upregulation of Fas_ligand in pulmonary artery smooth muscle cells from patients with idiopathic_pulmonary_arterial_hypertension .
16406650	0	Prostaglandin_J2	0,16	catechol-O-methyltransferase	25,53	Prostaglandin J2	catechol-O-methyltransferase	MESH:C037112	1312	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|activity activity|amod|END_ENTITY	Prostaglandin_J2 reduces catechol-O-methyltransferase activity and enhances dopamine_toxicity in neuronal cells .
7824084	0	Prostaglandins	0,14	ACTH	27,31	Prostaglandins	ACTH	MESH:D011453	5443	Chemical	Gene	mediate|nsubj|START_ENTITY mediate|dobj|response response|compound|END_ENTITY	Prostaglandins mediate the ACTH response to interleukin-1-beta instilled into the hypothalamic median eminence .
11447268	0	Prostaglandins	0,14	CREB	32,36	Prostaglandins	CREB	MESH:D011453	12912(Tax:10090)	Chemical	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|compound|END_ENTITY	Prostaglandins are required for CREB activation and cellular proliferation during liver_regeneration .
11854843	0	Prostaglandins	33,47	Interleukin-6	0,13	Prostaglandins	Interleukin-6	MESH:D011453	16193(Tax:10090)	Chemical	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	Interleukin-6 Gene Expression by Prostaglandins and Cyclic_AMP Mediated by Multiple Regulatory Elements .
3467533	0	Prostaglandins	0,14	PGD_2	44,49	Prostaglandins	PGD 2	MESH:D011453	5730	Chemical	Gene	START_ENTITY|dep|effect effect|nmod|END_ENTITY	Prostaglandins : antiproliferative effect of PGD_2 on cultured human glioma cells .
23319937	0	Prostaglandins	0,14	PPARy	18,23	Prostaglandins	PPARy	MESH:D011453	5468	Chemical	Gene	START_ENTITY|nmod|Modulators Modulators|compound|END_ENTITY	Prostaglandins as PPARy Modulators in Adipogenesis .
3464936	0	Prostaglandins	0,14	angiotensin_II	47,61	Prostaglandins	angiotensin II	MESH:D011453	24179(Tax:10116)	Chemical	Gene	mediate|nsubj|START_ENTITY mediate|dobj|effects effects|nmod|END_ENTITY	Prostaglandins mediate some central effects of angiotensin_II .
417634	0	Prostaglandins	0,14	bradykinin	44,54	Prostaglandins	bradykinin	MESH:D011453	478666(Tax:9615)	Chemical	Gene	START_ENTITY|dep|responses responses|dep|END_ENTITY	Prostaglandins : renal vascular responses to bradykinin , histamine , and nitroglycerine .
6243754	0	Prostaglandins	0,14	erythropoietin	26,40	Prostaglandins	erythropoietin	MESH:D011453	2056	Chemical	Gene	START_ENTITY|dep|production production|compound|END_ENTITY	Prostaglandins and kidney erythropoietin production .
6761139	0	Prostaglandins	0,14	erythropoietin	29,43	Prostaglandins	erythropoietin	MESH:D011453	13856(Tax:10090)	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|production production|compound|END_ENTITY	Prostaglandins activation of erythropoietin production and erythroid progenitor cells .
8039811	0	Prostaglandins	0,14	lipoprotein_lipase	23,41	Prostaglandins	lipoprotein lipase	MESH:D011453	4023	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|expression expression|amod|END_ENTITY	Prostaglandins inhibit lipoprotein_lipase gene expression in macrophages .
12184998	0	Prostaglandins	0,14	renin	29,34	Prostaglandins	renin	MESH:D011453	24715(Tax:10116)	Chemical	Gene	START_ENTITY|acl:relcl|increase increase|dobj|production production|compound|END_ENTITY	Prostaglandins that increase renin production in response to ACE inhibition are not derived from cyclooxygenase-1 .
341227	0	Prostaglandins	0,14	renin	52,57	Prostaglandins	renin	MESH:D011453	100358545(Tax:9986)	Chemical	Gene	START_ENTITY|dep|Stimulation Stimulation|nmod|release release|compound|END_ENTITY	Prostaglandins and renin release : I. Stimulation of renin release from rabbit renal cortical slices by PGI2 .
6251763	0	Prostaglandins	0,14	renin	24,29	Prostaglandins	renin	MESH:D011453	5972	Chemical	Gene	START_ENTITY|dep|role role|nmod|regulation regulation|compound|END_ENTITY	Prostaglandins : role in renin regulation and mediation of antihypertensive drug effects .
7675628	0	Prostaglandins	0,14	renin	50,55	Prostaglandins	renin	MESH:D011453	24715(Tax:10116)	Chemical	Gene	involved|nsubjpass|START_ENTITY involved|nmod|stimulation stimulation|nmod|expression expression|compound|END_ENTITY	Prostaglandins are involved in the stimulation of renin gene expression in 2 kidney-1 clip rats .
11729115	0	Prostanoid	0,10	COX-2	26,31	Prostanoid	COX-2	CHEBI:26347	17709(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Prostanoid production via COX-2 as a causative mechanism of rodent postoperative_ileus .
23840206	0	Protamine	29,38	Insulin	14,21	Protamine	Insulin	null	3630	Chemical	Gene	Suspension|compound|START_ENTITY Suspension|compound|END_ENTITY	Comparison of Insulin Lispro Protamine Suspension with NPH Insulin in Pregnant Women with Type 2 and Gestational Diabetes_Mellitus : Maternal and Perinatal Outcomes .
26499176	0	Protamine	22,31	Insulin	7,14	Protamine	Insulin	null	3630	Chemical	Gene	Suspension|compound|START_ENTITY Suspension|compound|END_ENTITY	Use of Insulin Lispro Protamine Suspension in Pregnancy .
23266625	0	Protamine	0,9	bone_sialoprotein	21,38	Protamine	bone sialoprotein	null	24477(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Protamine stimulates bone_sialoprotein gene expression .
1617779	0	Protamine	0,9	endothelium-derived_relaxing_factor	19,54	Protamine	endothelium-derived relaxing factor	null	51327	Chemical	Gene	releases|nsubj|START_ENTITY releases|dobj|END_ENTITY	Protamine releases endothelium-derived_relaxing_factor from systemic arteries .
18454177	0	Protein_cysteine_sulfinic_acid	0,30	sulfiredoxin	42,54	Protein cysteine sulfinic acid	sulfiredoxin	null	140809	Chemical	Gene	reductase|amod|START_ENTITY reductase|appos|END_ENTITY	Protein_cysteine_sulfinic_acid reductase -LRB- sulfiredoxin -RRB- as a regulator of cell proliferation and drug response .
26889254	0	Protocatechuic_aldehyde	0,23	c-Jun_N-terminal_kinase	118,141	Protocatechuic aldehyde	c-Jun N-terminal kinase	MESH:C005581	5599	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|pathway pathway|amod|END_ENTITY	Protocatechuic_aldehyde inhibits TNF-a-induced fibronectin expression in human umbilical vein endothelial cells via a c-Jun_N-terminal_kinase dependent pathway .
12224200	0	Protocol	0,8	insulin	76,83	Protocol	insulin	null	3630	Chemical	Gene	START_ENTITY|nmod|therapy therapy|compound|END_ENTITY	Protocol for outpatient screening and initiation of continuous subcutaneous insulin infusion therapy : impact on cost and quality .
17720738	0	Protocol_0102	154,167	CPT-11	20,26	Protocol 0102	CPT-11	null	963084(Tax:115711)	Chemical	Gene	START_ENTITY|nsubj|study study|nmod|END_ENTITY	Phase I/II study of CPT-11 plus UFT in patients with advanced/recurrent colorectal_cancer : Osaka Gastrointestinal_Cancer Chemotherapy Study Group -LRB- OGSG -RRB- : Protocol_0102 .
22486775	0	Provitamin_A_carotenoids	0,24	matrix_metalloproteinase-9	59,85	Provitamin A carotenoids	matrix metalloproteinase-9	null	4318	Chemical	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	Provitamin_A_carotenoids are independently associated with matrix_metalloproteinase-9 in plasma samples from a general population .
24348668	0	Prunetin	10,18	MUC5AC	36,42	Prunetin	MUC5AC	MESH:C083295	4586	Chemical	Gene	START_ENTITY|nmod|Expression Expression|compound|END_ENTITY	Effect of Prunetin on TNF-a-Induced MUC5AC Mucin Gene Expression , Production , Degradation of IkB and Translocation of NF-kB p65 in Human Airway Epithelial Cells .
23359228	0	Psammaplin_A	0,12	helicase	44,52	Psammaplin A	helicase	MESH:C098378	164045	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Psammaplin_A inhibits hepatitis_C virus NS3 helicase .
24823621	0	Pseudaminic_acid	0,16	Siglec-10	96,105	Pseudaminic acid	Siglec-10	MESH:C513444	89790	Chemical	Gene	START_ENTITY|nsubj|expression expression|nmod|receptor receptor|compound|END_ENTITY	Pseudaminic_acid on Campylobacter_jejuni flagella modulates dendritic cell IL-10 expression via Siglec-10 receptor : a novel flagellin-host interaction .
24446431	0	Pseudilins	0,10	IspD	84,88	Pseudilins	IspD	null	814779(Tax:3702)	Chemical	Gene	START_ENTITY|dep|inhibitors inhibitors|nmod|END_ENTITY	Pseudilins : halogenated , allosteric inhibitors of the non-mevalonate pathway enzyme IspD .
8003491	0	Pseudosubstrate	0,15	CDPK	30,34	Pseudosubstrate	CDPK	null	100797449	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Pseudosubstrate inhibition of CDPK , a protein kinase with a calmodulin-like domain .
25806947	0	Pseudouridine	75,88	hPus1p	101,107	Pseudouridine	hPus1p	MESH:D011560	80324	Chemical	Gene	Synthase|compound|START_ENTITY Synthase|appos|END_ENTITY	Correction : Steroid_Receptor_RNA_Activator -LRB- SRA -RRB- Modification by the Human Pseudouridine Synthase 1 -LRB- hPus1p -RRB- : RNA Binding , Activity , and Atomic Model .
19223576	0	Psoralidin	0,10	Akt	80,83	Psoralidin	Akt	MESH:C102768	207	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Psoralidin , an herbal molecule , inhibits phosphatidylinositol 3-kinase-mediated Akt signaling in androgen-independent_prostate_cancer cells .
20951127	0	Psoralidin	0,10	iNOS	32,36	Psoralidin	iNOS	MESH:C102768	4843	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Psoralidin inhibits LPS-induced iNOS expression via repressing Syk-mediated activation of PI3K-IKK-IkB signaling pathways .
12702588	0	Psoriasin	0,9	Jab1	25,29	Psoriasin	Jab1	null	26754(Tax:10090)	Chemical	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Psoriasin interacts with Jab1 and influences breast_cancer progression .
12855640	0	Psoriasin	0,9	S100A7	11,17	Psoriasin	S100A7	null	6278	Chemical	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	Psoriasin -LRB- S100A7 -RRB- expression is associated with poor outcome in estrogen receptor-negative invasive breast_cancer .
18606705	0	Psoriasin	32,41	S100A7	24,30	Psoriasin	S100A7	null	6278	Chemical	Gene	activity|appos|START_ENTITY activity|nmod|END_ENTITY	Chemotactic activity of S100A7 -LRB- Psoriasin -RRB- is mediated by the receptor for advanced glycation end products and potentiates inflammation with highly homologous but functionally distinct S100A15 .
22788918	0	PtCl	12,16	cis-1	20,25	PtCl	cis-1	null	1154	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|appos|END_ENTITY	Revisiting -LSB- PtCl -LRB- cis-1 ,4 - DACH -RRB- -RSB- : an underestimated antitumor drug with potential application to the treatment of oxaliplatin-refractory colorectal_cancer .
27009967	0	Pterosin_B	0,10	Sik3	85,89	Pterosin B	Sik3	MESH:C586064	70661(Tax:10090)	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|nmod|END_ENTITY	Pterosin_B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3 .
19617202	0	Pterostilbene	100,113	Matrix_Metalloproteinase-9	132,158	Pterostilbene	Matrix Metalloproteinase-9	MESH:C107773	4318	Chemical	Gene	START_ENTITY|nmod|Inhibition Inhibition|nmod|END_ENTITY	Suppression of Heregulin-b1 / HER2-Modulated Invasive and Aggressive Phenotype of Breast_Carcinoma by Pterostilbene via Inhibition of Matrix_Metalloproteinase-9 , p38 Kinase Cascade and Akt Activation .
23974882	0	Pterygium	55,64	Aquaporin-1	24,35	Pterygium	Aquaporin-1	null	358	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Increased Expression of Aquaporin-1 and Aquaporin-3 in Pterygium .
26903201	0	Pterygium	75,84	CXCR4	27,32	Pterygium	CXCR4	null	7852	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	The Influence of Chemokine CXCR4 and Cyclooxygenase-2 in the Recurrence of Pterygium .
20346059	0	Puerarin	0,8	C-reactive_protein	18,36	Puerarin	C-reactive protein	MESH:C033607	1401	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Puerarin inhibits C-reactive_protein expression via suppression of nuclear factor kappaB activation in lipopolysaccharide-induced peripheral blood mononuclear cells of patients with stable angina_pectoris .
26201474	0	Puerarin	10,18	ICAM-1	36,42	Puerarin	ICAM-1	MESH:C033607	25464(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of Puerarin on Expression of ICAM-1 and TNF-a in Kidneys of Diabetic Rats .
26201474	0	Puerarin	10,18	ICAM-1	36,42	Puerarin	ICAM-1	MESH:C033607	25464(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of Puerarin on Expression of ICAM-1 and TNF-a in Kidneys of Diabetic Rats .
25817234	0	Puerarin	0,8	MCP-1	41,46	Puerarin	MCP-1	MESH:C033607	6347	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Puerarin suppresses high glucose-induced MCP-1 expression via modulating histone methylation in cultured endothelial cells .
16038632	0	Puerarin	0,8	c-fos	27,32	Puerarin	c-fos	MESH:C033607	314322(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	Puerarin reduces increased c-fos , c-jun , and type IV collagen expression caused by high glucose in glomerular mesangial cells .
22470138	0	Puerarin	0,8	caspase-3	18,27	Puerarin	caspase-3	MESH:C033607	25402(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Puerarin inhibits caspase-3 expression in osteoblasts of diabetic rats .
21884717	0	Puerarin	0,8	endothelial_nitric_oxide_synthase	19,52	Puerarin	endothelial nitric oxide synthase	MESH:C033607	4846	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Puerarin activates endothelial_nitric_oxide_synthase through estrogen_receptor-dependent PI3-kinase and calcium-dependent AMP-activated protein kinase .
23907019	0	Puerarin	0,8	estrogen_receptor-a	138,157	Puerarin	estrogen receptor-a	MESH:C033607	2099	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	Puerarin suppresses proliferation of endometriotic stromal cells in part via differential recruitment of nuclear receptor coregulators to estrogen_receptor-a .
25774183	0	Puerarin	0,8	hypoxia_inducible_factor-1_alpha	19,51	Puerarin	hypoxia inducible factor-1 alpha	MESH:C033607	29560(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|xcomp|END_ENTITY	Puerarin decreases hypoxia_inducible_factor-1_alpha in the hippocampus of vascular_dementia rats .
21857089	0	Puerarin	0,8	iNOS	18,22	Puerarin	iNOS	MESH:C033607	18126(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Puerarin inhibits iNOS , COX-2 and CRP expression via suppression of NF-kB activation in LPS-induced RAW264 .7 macrophage cells .
24854571	0	Puerarin	0,8	osteoprotegerin	33,48	Puerarin	osteoprotegerin	MESH:C033607	4982	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Puerarin concurrently stimulates osteoprotegerin and inhibits receptor activator of NF-kB ligand -LRB- RANKL -RRB- and interleukin-6 production in human osteoblastic MG-63 cells .
24085032	0	Punicalagin	0,11	p53	62,65	Punicalagin	p53	MESH:C115642	7157	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	Punicalagin , a polyphenol in pomegranate juice , downregulates p53 and attenuates hypoxia-induced apoptosis in cultured human placental syncytiotrophoblasts .
19686814	0	Puqienine_E	0,11	angiotensin_converting_enzyme	16,45	Puqienine E	angiotensin converting enzyme	null	1636	Chemical	Gene	START_ENTITY|dep|inhibitory inhibitory|amod|END_ENTITY	Puqienine_E : an angiotensin_converting_enzyme inhibitory steroidal_alkaloid from Fritillaria puqiensis .
24287461	0	Purine	26,32	ABCG2	72,77	Purine	ABCG2	MESH:C030985	9429	Chemical	Gene	Derivatives|compound|START_ENTITY Derivatives|nmod|END_ENTITY	Metabolic Interactions of Purine Derivatives with Human ABC Transporter ABCG2 : Genetic Testing to Assess Gout Risk .
1066699	0	Purine	0,6	adenosine_deaminase	21,40	Purine	adenosine deaminase	MESH:C030985	100	Chemical	Gene	START_ENTITY|nmod|deficiency deficiency|amod|END_ENTITY	Purine metabolism in adenosine_deaminase deficiency .
387357	0	Purine	0,6	adenosine_deaminase	21,40	Purine	adenosine deaminase	MESH:C030985	100	Chemical	Gene	START_ENTITY|nmod|deficiency deficiency|amod|END_ENTITY	Purine metabolism in adenosine_deaminase deficiency .
471597	0	Purine	0,6	adenosine_deaminase	88,107	Purine	adenosine deaminase	MESH:C030985	100	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|nmod|child child|amod|END_ENTITY	Purine and phosphoribosylpyrophosphate metabolism of lymphocytes and erythrocytes of an adenosine_deaminase deficient immunocompetent child .
14675146	0	Puromycin	0,9	mdr1a	32,37	Puromycin	mdr1a	MESH:D011691	170913(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Puromycin selectively increases mdr1a expression in immortalized rat brain endothelial cell lines .
26683996	0	Puromycin_aminonucleoside	0,25	ZO-1	72,76	Puromycin aminonucleoside	ZO-1	MESH:D011692	7082	Chemical	Gene	increases|amod|START_ENTITY podocyte|nsubj|increases podocyte|advcl|modulating modulating|dobj|END_ENTITY	Puromycin_aminonucleoside increases podocyte permeability by modulating ZO-1 in an oxidative stress-dependent manner .
23133483	0	Puromycin_aminonucleoside	0,25	p130Cas	36,43	Puromycin aminonucleoside	p130Cas	MESH:D011692	25414(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Puromycin_aminonucleoside modulates p130Cas of podocytes .
26120386	0	Purslane	0,8	GLP-1	19,24	Purslane	GLP-1	null	100125288	Chemical	Gene	Effect|amod|START_ENTITY Effect|nmod|END_ENTITY	Purslane Effect on GLP-1 and GLP-1_receptor in type 2 diabetes .
12228581	0	Putrescine	10,20	Ornithine_Decarboxylase	60,83	Putrescine	Ornithine Decarboxylase	MESH:D011700	18263(Tax:10090)	Chemical	Gene	Biosynthesis|nsubj|START_ENTITY Biosynthesis|nmod|Transfer Transfer|nmod|cDNA cDNA|compound|END_ENTITY	Increased Putrescine Biosynthesis through Transfer of Mouse Ornithine_Decarboxylase cDNA in Carrot Promotes Somatic Embryogenesis .
8076929	0	Putrescine	0,10	epidermal_growth_factor	29,52	Putrescine	epidermal growth factor	MESH:D011700	25313(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|comitogen comitogen|nmod|END_ENTITY	Putrescine as a comitogen of epidermal_growth_factor in rat liver growth .
18854426	0	Pycnogenol	0,10	adipose_differentiation-related_protein	105,144	Pycnogenol	adipose differentiation-related protein	MESH:C024070	123	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|nmod|END_ENTITY	Pycnogenol , an extract from French maritime pine , suppresses Toll-like receptor 4-mediated expression of adipose_differentiation-related_protein in macrophages .
24002221	0	Pyocyanin	0,9	IL-8	35,39	Pyocyanin	IL-8	MESH:D011710	3576	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|compound|END_ENTITY	Pyocyanin from Pseudomonas induces IL-8 production through the PKC and NF-kB pathways in U937 cells .
17653674	0	Pyoluteorin	45,56	PltR	19,23	Pyoluteorin	PltR	MESH:C095503	57817	Chemical	Gene	production|amod|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	LysR family factor PltR positively regulates Pyoluteorin production in a pathway-specific manner in Pseudomonas sp .
25111439	0	Pyrano-isochromanones	0,21	IL-6	25,29	Pyrano-isochromanones	IL-6	null	16193(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Pyrano-isochromanones as IL-6 inhibitors : synthesis , in vitro and in vivo antiarthritic activity .
18221871	0	Pyrazinoindolone	0,16	MAPKAP-K2	31,40	Pyrazinoindolone	MAPKAP-K2	null	9261	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Pyrazinoindolone inhibitors of MAPKAP-K2 .
26827137	0	Pyrazole	0,8	CB1	28,31	Pyrazole	CB1	MESH:C031280	1268	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|nmod|receptor receptor|compound|END_ENTITY	Pyrazole antagonists of the CB1 receptor with reduced brain penetration .
17764936	0	Pyrazole	0,8	HMG-CoA_reductase	23,40	Pyrazole	HMG-CoA reductase	MESH:C031280	3156	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Pyrazole inhibitors of HMG-CoA_reductase : an attempt to dramatically reduce synthetic complexity through minimal analog re-design .
1313873	0	Pyrazole	0,8	alcohol_dehydrogenase	13,34	Pyrazole	alcohol dehydrogenase	MESH:C031280	78959(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Pyrazole , an alcohol_dehydrogenase inhibitor , has dual effects on N-methyl-D-aspartate receptors of hippocampal pyramidal cells : agonist and noncompetitive antagonist .
6753929	0	Pyrazole	0,8	alcohol_dehydrogenase	72,93	Pyrazole	alcohol dehydrogenase	MESH:C031280	10327	Chemical	Gene	START_ENTITY|xcomp|binding binding|nmod|binary binary|nmod|END_ENTITY	Pyrazole binding in crystalline binary and ternary complexes with liver alcohol_dehydrogenase .
18619839	0	Pyrazole	0,8	coactivator_associated_arginine_methyltransferase_1	23,74	Pyrazole	coactivator associated arginine methyltransferase 1	MESH:C031280	10498	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Pyrazole inhibitors of coactivator_associated_arginine_methyltransferase_1 -LRB- CARM1 -RRB- .
22695126	0	Pyrazole_diaminopyrimidines	0,27	KDR	50,53	Pyrazole diaminopyrimidines	KDR	null	16542(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Pyrazole_diaminopyrimidines as dual inhibitors of KDR and Aurora_B kinases .
24900315	0	Pyrazolopyridine	0,16	B-Raf	31,36	Pyrazolopyridine	B-Raf	MESH:C118531	109880(Tax:10090)	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|nmod|END_ENTITY	Pyrazolopyridine Inhibitors of B-Raf -LRB- V600E -RRB- .
22607035	0	Pyrazolopyridines	0,17	LRRK2	46,51	Pyrazolopyridines	LRRK2	CHEBI:46699	120892	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Pyrazolopyridines as inhibitors of the kinase LRRK2 : a patent evaluation -LRB- WO2011141756 -RRB- .
18539455	0	Pyrazolopyridines	0,17	PDE4	70,74	Pyrazolopyridines	PDE4	CHEBI:46699	5141	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Pyrazolopyridines as a novel structural class of potent and selective PDE4 inhibitors .
20732811	0	Pyrazolopyridines	0,17	PDE4B	28,33	Pyrazolopyridines	PDE4B	CHEBI:46699	5142	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Pyrazolopyridines as potent PDE4B inhibitors : 5-heterocycle SAR .
20089401	0	Pyrazolopyrimidines	0,19	mammalian_target_of_rapamycin	86,115	Pyrazolopyrimidines	mammalian target of rapamycin	CHEBI:38669	2475	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Pyrazolopyrimidines as highly potent and selective , ATP-competitive inhibitors of the mammalian_target_of_rapamycin -LRB- mTOR -RRB- : optimization of the 1-substituent .
12639538	0	Pyridazinones	0,13	cyclooxygenase-2	27,43	Pyridazinones	cyclooxygenase-2	CHEBI:26414	29527(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Pyridazinones as selective cyclooxygenase-2 inhibitors .
3418515	0	Pyridine	0,8	P-450j	59,65	Pyridine	P-450j	MESH:C023666	25086(Tax:10116)	Chemical	Gene	induction|amod|START_ENTITY induction|dep|role role|nmod|END_ENTITY	Pyridine induction of cytochrome_P-450 in the rat : role of P-450j -LRB- alcohol-inducible form -RRB- in pyridine_N-oxidation .
3418515	0	Pyridine	0,8	cytochrome_P-450	22,38	Pyridine	cytochrome P-450	MESH:C023666	25251(Tax:10116)	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Pyridine induction of cytochrome_P-450 in the rat : role of P-450j -LRB- alcohol-inducible form -RRB- in pyridine_N-oxidation .
25137573	0	Pyridine-3-carboxamide-6-yl-ureas	0,33	DNA_gyrase	67,77	Pyridine-3-carboxamide-6-yl-ureas	DNA gyrase	null	7153	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Pyridine-3-carboxamide-6-yl-ureas as novel inhibitors of bacterial DNA_gyrase : Structure based design , synthesis , SAR and antimicrobial activity .
17618114	0	Pyridinylimidazole	0,18	Tie2	33,37	Pyridinylimidazole	Tie2	null	7010	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Pyridinylimidazole inhibitors of Tie2 kinase .
23078965	0	Pyridonepezils	0,14	AChE	25,29	Pyridonepezils	AChE	null	43	Chemical	Gene	START_ENTITY|appos|inhibitors inhibitors|compound|END_ENTITY	Pyridonepezils , new dual AChE inhibitors as potential drugs for the treatment of Alzheimer 's _ disease : synthesis , biological assessment , and molecular modeling .
26819674	0	Pyridones	0,9	EGFR	81,85	Pyridones	EGFR	MESH:D011728	1956	Chemical	Gene	START_ENTITY|nmod|Mutants Mutants|nmod|END_ENTITY	Pyridones as Highly Selective , Noncovalent Inhibitors of T790M Double Mutants of EGFR .
24842281	0	Pyridostigmine	162,176	Acetylcholinesterase	84,104	Pyridostigmine	Acetylcholinesterase	MESH:D011729	11423(Tax:10090)	Chemical	Gene	Comparison|nmod|START_ENTITY Evaluation|dep|Comparison Evaluation|nmod|Efficacy Efficacy|nmod|Inhibitors Inhibitors|nmod|END_ENTITY	The Evaluation of Prophylactic Efficacy of Newly Developed Reversible Inhibitors of Acetylcholinesterase in Soman-Poisoned Mice - A Comparison with Commonly Used Pyridostigmine .
2220258	0	Pyridostigmine	0,14	GHRH	59,63	Pyridostigmine	GHRH	MESH:D011729	2691	Chemical	Gene	restores|nsubj|START_ENTITY restores|xcomp|END_ENTITY	Pyridostigmine partially restores the GH responsiveness to GHRH in normal aging .
8258646	2	Pyridostigmine	218,232	GHRH	337,341	Pyridostigmine	GHRH	MESH:D011729	2691	Chemical	Gene	shown|nsubjpass|START_ENTITY shown|xcomp|reduce reduce|advcl|END_ENTITY	Pyridostigmine -LRB- PD -RRB- , an acetylcholinesterase inhibitor , has been shown to reduce the variability of the GH response to GHRH in normal subjects .
19215369	0	Pyridostigmine	0,14	Growth_Hormone	62,76	Pyridostigmine	Growth Hormone	MESH:D011729	2688	Chemical	Gene	Stimulates|nsubj|START_ENTITY Stimulates|dobj|Release Release|compound|END_ENTITY	Pyridostigmine , an Acetylcholinesterase Inhibitor , Stimulates Growth_Hormone Release , but has no Effect on Basal Thyrotrophin or Adrenocorticotrophin Levels , or the Thyrotrophin Response to Thyrotrophin-Releasing_Hormone .
11194708	0	Pyridostigmine	0,14	TRH	69,72	Pyridostigmine	TRH	MESH:D011729	7200	Chemical	Gene	restore|nsubj|START_ENTITY restore|nmod|inhibited inhibited|compound|END_ENTITY	Pyridostigmine and metoclopramide do not restore the TSH response to TRH inhibited by L-thyroxine treatment in children with goiter .
8344646	0	Pyridostigmine	0,14	TRH	42,45	Pyridostigmine	TRH	MESH:D011729	7200	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|END_ENTITY	Pyridostigmine effects on TSH response to TRH in adult and children obese subjects .
1357070	0	Pyridostigmine	0,14	growth_hormone	74,88	Pyridostigmine	growth hormone	MESH:D011729	2688	Chemical	Gene	reverses|nsubj|START_ENTITY reverses|dobj|inhibition inhibition|nmod|response response|amod|END_ENTITY	Pyridostigmine partially reverses dexamethasone-induced inhibition of the growth_hormone response to growth_hormone-releasing hormone .
1697660	0	Pyridostigmine	0,14	growth_hormone	73,87	Pyridostigmine	growth hormone	MESH:D011729	2688	Chemical	Gene	L-dopa|compound|START_ENTITY L-dopa|dep|not not|nmod|secretion secretion|compound|END_ENTITY	Pyridostigmine potentiates L-dopa - but not arginine - and galanin-induced growth_hormone secretion in children .
1806475	0	Pyridostigmine	0,14	growth_hormone	58,72	Pyridostigmine	growth hormone	MESH:D011729	2688	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|advcl|normalize normalize|dobj|responses responses|amod|END_ENTITY	Pyridostigmine enhances even if it does not normalize the growth_hormone responses to growth_hormone-releasing hormone in patients with Cushing 's _ disease .
1979261	0	Pyridostigmine	0,14	growth_hormone	54,68	Pyridostigmine	growth hormone	MESH:D011729	2688	Chemical	Gene	reverse|nsubj|START_ENTITY reverse|dobj|inhibition inhibition|compound|END_ENTITY	Pyridostigmine does not reverse dexamethasone-induced growth_hormone inhibition .
2118535	0	Pyridostigmine	0,14	growth_hormone	110,124	Pyridostigmine	growth hormone	MESH:D011729	2688	Chemical	Gene	blocks|nsubj|START_ENTITY blocks|dobj|effect effect|nmod|glucocorticoids glucocorticoids|nmod|secretion secretion|compound|END_ENTITY	Pyridostigmine blocks the inhibitory effect of glucocorticoids on growth_hormone-releasing_hormone stimulated growth_hormone secretion in normal man .
2499149	0	Pyridostigmine	0,14	growth_hormone	39,53	Pyridostigmine	growth hormone	MESH:D011729	2688	Chemical	Gene	counteracts|nsubj|START_ENTITY counteracts|dobj|response response|compound|END_ENTITY	Pyridostigmine counteracts the blunted growth_hormone response to growth_hormone-releasing hormone of obese children .
8306487	0	Pyridostigmine	0,14	growth_hormone	23,37	Pyridostigmine	growth hormone	MESH:D011729	2688	Chemical	Gene	release|amod|START_ENTITY release|compound|END_ENTITY	Pyridostigmine induced growth_hormone release in mania : focus on the cholinergic/somatostatin system .
8432781	0	Pyridostigmine	0,14	growth_hormone	27,41	Pyridostigmine	growth hormone	MESH:D011729	2688	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|dep|releasing releasing|nsubj|END_ENTITY	Pyridostigmine potentiates growth_hormone -LRB- GH -RRB- - releasing hormone-induced GH release in both men and women .
3126802	0	Pyridoxal	0,9	glycogen_phosphorylase_b	28,52	Pyridoxal	glycogen phosphorylase b	MESH:D011730	5834	Chemical	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Pyridoxal phosphate site in glycogen_phosphorylase_b : structure in native enzyme and in three derivatives with modified cofactors .
2401289	0	Pyridoxal_phosphate	0,19	ecdysteroid_receptor	61,81	Pyridoxal phosphate	ecdysteroid receptor	MESH:D011732	35540(Tax:7227)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	Pyridoxal_phosphate inhibits the DNA-binding activity of the ecdysteroid_receptor .
22365762	0	Pyridyl_aminothiazoles	0,22	Chk1	33,37	Pyridyl aminothiazoles	Chk1	null	1111	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Pyridyl_aminothiazoles as potent Chk1 inhibitors : optimization of cellular activity .
21074435	0	Pyridylmethylthio	0,17	VEGF	33,37	Pyridylmethylthio	VEGF	null	7422	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	Pyridylmethylthio derivatives as VEGF inhibitors .
22985433	0	Pyrimethamine	0,13	SOD1	34,38	Pyrimethamine	SOD1	MESH:D011739	6647	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|levels levels|nmod|END_ENTITY	Pyrimethamine decreases levels of SOD1 in leukocytes and cerebrospinal fluid of ALS patients : a phase I pilot study .
26586770	0	Pyrimidine	37,47	ASS1	22,26	Pyrimidine	ASS1	MESH:C030986	445	Chemical	Gene	Synthesis|compound|START_ENTITY Regulates|dobj|Synthesis Regulates|nsubj|END_ENTITY	The Urea Cycle Enzyme ASS1 Regulates Pyrimidine Synthesis in Tumors .
3339127	0	Pyrimidine	0,10	C-1300	47,53	Pyrimidine	C-1300	MESH:C030986	1034995(Tax:199310)	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Pyrimidine base degradation in cultured murine C-1300 neuroblastoma cells and in situ tumors .
26609109	0	Pyrimidine	34,44	DPYD	17,21	Pyrimidine	DPYD	MESH:C030986	1806	Chemical	Gene	Metabolism|compound|START_ENTITY Metabolism|compound|END_ENTITY	Hypermutation of DPYD Deregulates Pyrimidine Metabolism and Promotes Malignant Progression .
11597418	0	Pyrimidinylimidazole	0,20	p38	35,38	Pyrimidinylimidazole	p38	null	81649(Tax:10116)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Pyrimidinylimidazole inhibitors of p38 : cyclic N-1 imidazole substituents enhance p38 kinase inhibition and oral activity .
20952196	0	Pyrimidinylmethylphenyl_glucoside	0,33	SGLT2	60,65	Pyrimidinylmethylphenyl glucoside	SGLT2	null	6524	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Pyrimidinylmethylphenyl_glucoside as novel C-aryl_glucoside SGLT2 inhibitors .
3056958	0	Pyrimido-pyrimidine	0,19	EGF	34,37	Pyrimido-pyrimidine	EGF	CHEBI:48514	25313(Tax:10116)	Chemical	Gene	modulation|amod|START_ENTITY modulation|nmod|END_ENTITY	Pyrimido-pyrimidine modulation of EGF growth-promoting activity and p21ras expression in rat mammary adenocarcinoma cells .
23473235	0	Pyrimidoaminotropanes	0,21	mammalian_target_of_rapamycin	100,129	Pyrimidoaminotropanes	mammalian target of rapamycin	null	2475	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|dobj|inhibitors inhibitors|nmod|END_ENTITY	Pyrimidoaminotropanes as potent , selective , and efficacious small molecule kinase inhibitors of the mammalian_target_of_rapamycin -LRB- mTOR -RRB- .
26940742	0	Pyrithione_Zn	0,13	PHD3	79,83	Pyrithione Zn	PHD3	null	112399	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Pyrithione_Zn selectively inhibits hypoxia-inducible factor prolyl hydroxylase PHD3 .
2882441	0	Pyroglutamate	0,13	aminopeptidase	14,28	Pyroglutamate	aminopeptidase	MESH:D011761	10404	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Pyroglutamate aminopeptidase activity in human cerebrospinal fluid decreases with age .
22041057	0	Pyrrolamide	0,11	DNA_gyrase	12,22	Pyrrolamide	DNA gyrase	null	7153	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Pyrrolamide DNA_gyrase inhibitors : optimization of antibacterial activity and efficacy .
25009002	0	Pyrrole-3-carboxamides	0,22	JAK2	47,51	Pyrrole-3-carboxamides	JAK2	null	3717	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Pyrrole-3-carboxamides as potent and selective JAK2 inhibitors .
9396152	0	Pyrrole_butyric_acid	0,20	5_alpha-reductase	58,75	Pyrrole butyric acid	5 alpha-reductase	null	6715	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Pyrrole_butyric_acid derivatives as inhibitors of steroid 5_alpha-reductase .
21208093	0	Pyrrolidine_dithiocarbamate	0,27	HSP70	38,43	Pyrrolidine dithiocarbamate	HSP70	MESH:C020972	266759(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Pyrrolidine_dithiocarbamate modulates HSP70 , iNOS , and apoptosis during hemorrhagic_shock resuscitation in rats .
26920699	0	Pyrrolidine_dithiocarbamate	0,27	Nrf2	42,46	Pyrrolidine dithiocarbamate	Nrf2	MESH:C020972	18024(Tax:10090)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|pathway pathway|amod|END_ENTITY	Pyrrolidine_dithiocarbamate activates the Nrf2 pathway in astrocytes .
9450660	0	Pyrrolidine_dithiocarbamate	0,27	VCAM-1	54,60	Pyrrolidine dithiocarbamate	VCAM-1	MESH:C020972	25361(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Pyrrolidine_dithiocarbamate inhibits cytokine-induced VCAM-1 gene expression in rat cardiac myocytes .
12387820	0	Pyrrolidine_dithiocarbamate	0,27	cyclooxygenase-2	36,52	Pyrrolidine dithiocarbamate	cyclooxygenase-2	MESH:C020972	19225(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Pyrrolidine_dithiocarbamate induces cyclooxygenase-2 expression in NIH 3T3 fibroblast cells .
16926159	0	Pyrrolidine_dithiocarbamate	0,27	interleukin-6	37,50	Pyrrolidine dithiocarbamate	interleukin-6	MESH:C020972	24498(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Pyrrolidine_dithiocarbamate inhibits interleukin-6 signaling through impaired STAT3 activation and association with transcriptional coactivators in hepatocytes .
8896414	0	Pyrrolidine_dithiocarbamate	0,27	interleukin-6	55,68	Pyrrolidine dithiocarbamate	interleukin-6	MESH:C020972	3569	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|nmod|activity activity|amod|END_ENTITY	Pyrrolidine_dithiocarbamate inhibits the production of interleukin-6 , interleukin-8 , and granulocyte-macrophage_colony-stimulating_factor by human endothelial cells in response to inflammatory mediators : modulation of NF-kappa_B and AP-1 transcription factors activity .
7513157	0	Pyrrolidine_dithiocarbamate	0,27	interleukin_1_beta	51,69	Pyrrolidine dithiocarbamate	interleukin 1 beta	MESH:C020972	24494(Tax:10116)	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|expression expression|amod|END_ENTITY	Pyrrolidine_dithiocarbamate differentially affects interleukin_1_beta - and cAMP-induced nitric_oxide_synthase expression in rat renal mesangial cells .
24365462	0	Pyrrolidine_dithiocarbamate	0,27	nuclear_factor_kB	126,143	Pyrrolidine dithiocarbamate	nuclear factor kB	MESH:C020972	309165(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|nmod|inhibition inhibition|nmod|END_ENTITY	Pyrrolidine_dithiocarbamate attenuates surgery-induced neuroinflammation and cognitive_dysfunction possibly via inhibition of nuclear_factor_kB .
7986199	0	Pyrrolidine_dithiocarbamate	0,27	nuclear_factor_kappa_B	51,73	Pyrrolidine dithiocarbamate	nuclear factor kappa B	MESH:C020972	4790	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|activation activation|amod|END_ENTITY	Pyrrolidine_dithiocarbamate , a potent inhibitor of nuclear_factor_kappa_B -LRB- NF-kappa_B -RRB- activation , prevents apoptosis in human promyelocytic_leukemia HL-60 cells and thymocytes .
20514517	0	Pyrrolidine_dithiocarbamate	0,27	p38_MAPK	38,46	Pyrrolidine dithiocarbamate	p38 MAPK	MESH:C020972	26416(Tax:10090)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Pyrrolidine_dithiocarbamate activates p38_MAPK and protects brain endothelial cells from apoptosis : a mechanism for the protective effect in stroke ?
12788348	0	Pyrrolidinobenzoic_acid	0,23	neuraminidase	54,67	Pyrrolidinobenzoic acid	neuraminidase	null	4758	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Pyrrolidinobenzoic_acid inhibitors of influenza virus neuraminidase : modifications of essential pyrrolidinone ring substituents .
22677529	0	Pyrrolidinobenzoic_acid	0,23	neuraminidase	54,67	Pyrrolidinobenzoic acid	neuraminidase	null	4758	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Pyrrolidinobenzoic_acid inhibitors of influenza virus neuraminidase : the hydrophobic side chain influences type A subtype selectivity .
18606544	0	Pyrrolidinyl_pyridone	0,21	prolyl_oligopeptidase	71,92	Pyrrolidinyl pyridone	prolyl oligopeptidase	null	5550	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Pyrrolidinyl_pyridone and pyrazinone analogues as potent inhibitors of prolyl_oligopeptidase -LRB- POP -RRB- .
17480064	0	Pyrrolopyridine	0,15	mitogen-activated_protein_kinase-activated_protein_kinase_2	30,89	Pyrrolopyridine	mitogen-activated protein kinase-activated protein kinase 2	CHEBI:46771	9261	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Pyrrolopyridine inhibitors of mitogen-activated_protein_kinase-activated_protein_kinase_2 -LRB- MK-2 -RRB- .
26943020	0	Pyrrolopyrimidine	0,17	Multidrug_Resistance-Associated_Protein_1	53,94	Pyrrolopyrimidine	Multidrug Resistance-Associated Protein 1	MESH:C527741	4363	Chemical	Gene	Derivatives|compound|START_ENTITY Derivatives|nmod|END_ENTITY	Pyrrolopyrimidine Derivatives as Novel Inhibitors of Multidrug_Resistance-Associated_Protein_1 -LRB- MRP1 , ABCC1 -RRB- .
12932673	0	Pyrrolopyrimidine	0,17	c-Src	18,23	Pyrrolopyrimidine	c-Src	MESH:C527741	6714	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Pyrrolopyrimidine c-Src inhibitors reduce growth , adhesion , motility and invasion of prostate_cancer cells in vitro .
23613773	0	Pyrroloquinoline_quinine	0,24	NFATc1	63,69	Pyrroloquinoline quinine	NFATc1	null	18018(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Pyrroloquinoline_quinine inhibits RANKL-mediated expression of NFATc1 in part via suppression of c-Fos in mouse bone marrow cells and inhibits wear particle-induced osteolysis in mice .
7723599	0	Pyrroloquinoline_quinone	0,24	alpha-melanocyte_stimulating_hormone	77,113	Pyrroloquinoline quinone	alpha-melanocyte stimulating hormone	MESH:D045542	18976(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Pyrroloquinoline_quinone -LRB- PQQ -RRB- inhibits the expression of tyrosinase mRNA by alpha-melanocyte_stimulating_hormone in murine B16 melanoma cells .
19026989	0	Pyrroloquinoline_quinone	0,24	iNOS	36,40	Pyrroloquinoline quinone	iNOS	MESH:D045542	24599(Tax:10116)	Chemical	Gene	attenuates|amod|START_ENTITY END_ENTITY|nsubj|attenuates	Pyrroloquinoline_quinone attenuates iNOS gene expression in the injured spinal cord .
23085227	0	Pyrroloquinoline_quinone	0,24	protein_tyrosine_phosphatase_1B	34,65	Pyrroloquinoline quinone	protein tyrosine phosphatase 1B	MESH:D045542	19246(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Pyrroloquinoline_quinone , a novel protein_tyrosine_phosphatase_1B inhibitor , activates insulin signaling in C2C12 myotubes and improves impaired_glucose_tolerance in diabetic KK-A -LRB- y -RRB- mice .
16978869	0	Pyruvate	0,8	Akt	106,109	Pyruvate	Akt	MESH:D019289	24185(Tax:10116)	Chemical	Gene	protects|nsubj|START_ENTITY protects|advcl|activating activating|dobj|END_ENTITY	Pyruvate protects cerebellar granular cells from 6-hydroxydopamine-induced cytotoxicity by activating the Akt signaling pathway and increasing glutathione peroxidase expression .
12223863	0	Pyruvate	85,93	Alternative_Oxidase	46,65	Pyruvate	Alternative Oxidase	MESH:D019289	547924(Tax:3847)	Chemical	Gene	Kinetics|nmod|START_ENTITY Kinetics|nmod|END_ENTITY	Substrate Kinetics of the Plant Mitochondrial Alternative_Oxidase and the Effects of Pyruvate .
21132271	0	Pyruvate	0,8	PAI-1	61,66	Pyruvate	PAI-1	MESH:D019289	5054	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|expression expression|compound|END_ENTITY	Pyruvate promotes tumor angiogenesis through HIF-1-dependent PAI-1 expression .
20410436	0	Pyruvate	0,8	PGC1alpha	20,29	Pyruvate	PGC1alpha	MESH:D019289	10891	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Pyruvate suppresses PGC1alpha expression and substrate utilization despite increased respiratory chain content in C2C12 myotubes .
22282883	0	Pyruvate	0,8	erythropoietin	82,96	Pyruvate	erythropoietin	MESH:D019289	24335(Tax:10116)	Chemical	Gene	protects|nsubj|START_ENTITY protects|advcl|activating activating|dobj|END_ENTITY	Pyruvate protects the brain against ischemia-reperfusion injury by activating the erythropoietin signaling pathway .
2184057	0	Pyruvate	0,8	insulin	37,44	Pyruvate	insulin	MESH:D019289	3630	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Pyruvate dehydrogenase activation by insulin in human circulating lymphocytes and the possible pathway involved .
12773762	0	Pyruvate	0,8	myoglobin	20,29	Pyruvate	myoglobin	MESH:D019289	59108(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|END_ENTITY	Pyruvate attenuates myoglobin in vitro toxicity .
6788061	1	Pz	723,725	PRL	708,711	Pz	PRL	null	24683(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Perphenazine -LRB- Pz -RRB- produced a dose-related increase in plasma PRL , but stimulation of tumour growth in the absence of E2 required a minimal level of plasma PRL induced by Pz -LRB- 0.15 mg/100 g body wt/day or more -RRB- .
15735038	0	QLT0254	78,85	integrin-linked_kinase	14,36	QLT0254	integrin-linked kinase	null	3611	Chemical	Gene	inhibitor|appos|START_ENTITY END_ENTITY|nmod|inhibitor	Inhibition of integrin-linked_kinase by a selective small molecule inhibitor , QLT0254 , inhibits the PI3K/PKB/mTOR , Stat3 , and FKHR pathways and tumor growth , and enhances gemcitabine-induced apoptosis in human orthotopic primary pancreatic_cancer xenografts .
19409087	0	QLT0267	0,7	ILK	70,73	QLT0267	ILK	MESH:C552362	3611	Chemical	Gene	targeting|advmod|START_ENTITY targeting|dobj|kinase kinase|appos|END_ENTITY	QLT0267 , a small molecule inhibitor targeting integrin-linked kinase -LRB- ILK -RRB- , and docetaxel can combine to produce synergistic interactions linked to enhanced cytotoxicity , reductions in P-AKT levels , altered F-actin architecture and improved treatment outcomes in an orthotopic breast_cancer model .
21358264	0	QLT0267	257,264	ILK	242,245	QLT0267	ILK	MESH:C552362	16202(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Validating the use of a luciferase labeled breast_cancer cell line , MDA435LCC6 , as a means to monitor tumor progression and to assess the therapeutic activity of an established anticancer drug , docetaxel -LRB- Dt -RRB- alone or in combination with the ILK inhibitor , QLT0267 .
23645983	0	QLT0267	61,68	ILK	120,123	QLT0267	ILK	MESH:C552362	3611	Chemical	Gene	START_ENTITY|dobj|Integrin-linked_Kinase Integrin-linked_Kinase|appos|END_ENTITY	Urokinase-type_Plasminogen_Activator -LRB- uPA -RRB- is Inhibited with QLT0267 a Small Molecule Targeting Integrin-linked_Kinase -LRB- ILK -RRB- .
11348602	0	QUinapril	4,13	ACE	66,69	QUinapril	ACE	MESH:C041125	1636	Chemical	Gene	Trial|compound|START_ENTITY Trial|dep|evaluation evaluation|nmod|therapy therapy|compound|END_ENTITY	The QUinapril Ischemic Event Trial -LRB- QUIET -RRB- : evaluation of chronic ACE inhibitor therapy in patients with ischemic_heart_disease and preserved left ventricular function .
8357782	0	QUinapril	4,13	ACE	85,88	QUinapril	ACE	MESH:C041125	1636	Chemical	Gene	Trial|compound|START_ENTITY Trial|dep|evaluation evaluation|nmod|therapy therapy|compound|END_ENTITY	The QUinapril Ischemic Event Trial -LRB- QUIET -RRB- design and methods : evaluation of chronic ACE inhibitor therapy after coronary artery intervention .
2076814	0	Qa	53,55	class_I	56,63	Qa	class I	null	11980(Tax:10090)	Chemical	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	Gene conversion in the evolution of both the H-2 and Qa class_I genes of the murine major histocompatibility complex .
16893670	0	Qi	9,11	Akt	59,62	Qi	Akt	null	207	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	External Qi of Yan Xin Qigong differentially regulates the Akt and extracellular signal-regulated kinase pathways and is cytotoxic to cancer cells but not to normal cells .
23363659	0	Qi	9,11	Akt	53,56	Qi	Akt	null	207	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	External Qi of Yan Xin Qigong inhibits activation of Akt , Erk1/2 and NF - B and induces cell cycle arrest and apoptosis in colorectal_cancer cells .
22711909	0	Quercetin	0,9	ABCA1	19,24	Quercetin	ABCA1	MESH:D011794	19	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	Quercetin enhances ABCA1 expression and cholesterol efflux through a p38-dependent pathway in macrophages .
25875015	0	Quercetin	0,9	Apolipoprotein_B	20,36	Quercetin	Apolipoprotein B	MESH:D011794	338	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Quercetin Represses Apolipoprotein_B Expression by Inhibiting the Transcriptional Activity of C/EBPb .
25875015	0	Quercetin	0,9	Apolipoprotein_B	20,36	Quercetin	Apolipoprotein B	MESH:D011794	338	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Quercetin Represses Apolipoprotein_B Expression by Inhibiting the Transcriptional Activity of C/EBPb .
25211642	0	Quercetin	43,52	Bcl-2	18,23	Quercetin	Bcl-2	MESH:D011794	596	Chemical	Gene	Proteins|nmod|START_ENTITY Proteins|compound|END_ENTITY	Direct Binding of Bcl-2 Family Proteins by Quercetin Triggers Its Pro-Apoptotic Activity .
21275387	0	Quercetin	0,9	CXCL8	52,57	Quercetin	CXCL8	MESH:D011794	3576	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|nmod|END_ENTITY	Quercetin reduces neutrophil recruitment induced by CXCL8 , LTB4 , and fMLP : inhibition of actin polymerization .
12959295	0	Quercetin	0,9	CYP3A	36,41	Quercetin	CYP3A	MESH:D011794	1576	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Quercetin , an in vitro inhibitor of CYP3A , does not contribute to the interaction between nifedipine and grapefruit juice .
18329630	0	Quercetin	0,9	CYP3A	93,98	Quercetin	CYP3A	MESH:D011794	170509(Tax:10116)	Chemical	Gene	pretreatment|compound|START_ENTITY increases|nsubj|pretreatment increases|dobj|bioavailability bioavailability|dep|involvement involvement|nmod|inhibition inhibition|compound|END_ENTITY	Quercetin pretreatment increases the bioavailability of pioglitazone in rats : involvement of CYP3A inhibition .
20184953	0	Quercetin	0,9	Dcytb	62,67	Quercetin	Dcytb	MESH:D011794	79901	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Quercetin is a substrate for the transmembrane oxidoreductase Dcytb .
17377063	5	Quercetin	761,770	HIF-1alpha	891,901	Quercetin	HIF-1alpha	MESH:D011794	3091	Chemical	Gene	delayed|nsubj|START_ENTITY delayed|dobj|disappearance disappearance|acl:relcl|occurred occurred|nmod|hydroxylase hydroxylase|appos|enzyme enzyme|nmod|hydroxylation hydroxylation|compound|END_ENTITY	Quercetin delayed HIF-1alpha protein disappearance , which occurred by inhibiting HIF-prolyl hydroxylase -LRB- HPH -RRB- , the key enzyme for HIF-1alpha hydroxylation and subsequent von_Hippel_Lindau-dependent HIF-1alpha degradation .
17973296	4	Quercetin	571,580	HIF-1alpha	691,701	Quercetin	HIF-1alpha	MESH:D011794	3091	Chemical	Gene	found|nsubjpass|START_ENTITY found|xcomp|induce induce|dobj|accumulation accumulation|compound|END_ENTITY	Quercetin , a flavonoid with anti-oxidant , anti-inflammatory , and kinase modulating properties , has been found to induce HIF-1alpha accumulation and VEGF secretion in normoxia .
18655183	0	Quercetin	0,9	HIF-1alpha	86,96	Quercetin	HIF-1alpha	MESH:D011794	3091	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|accumulation accumulation|nmod|END_ENTITY	Quercetin suppresses hypoxia-induced accumulation of hypoxia-inducible_factor-1alpha -LRB- HIF-1alpha -RRB- through inhibiting protein synthesis .
10484327	0	Quercetin	0,9	ICAM-1	29,35	Quercetin	ICAM-1	MESH:D011794	3383	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Quercetin inhibits inducible ICAM-1 expression in human endothelial cells through the JNK pathway .
18982426	0	Quercetin	0,9	ICAM-1	37,43	Quercetin	ICAM-1	MESH:D011794	3383	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Quercetin inhibits IL-1_beta-induced ICAM-1 expression in pulmonary epithelial cell line A549 through the MAPK pathways .
22661653	8	Quercetin	1225,1234	IL-6	1381,1385	Quercetin	IL-6	MESH:D011794	3569	Chemical	Gene	reduced|nsubj|START_ENTITY reduced|parataxis|significant significant|nsubj|reduction reduction|nmod|END_ENTITY	Quercetin reduced IL-6 , IL-8 and TNFa protein production in supernatants of all GO samples -LRB- n = 4 -RRB- in a dose-dependent manner ; however , only the reduction in IL-6 was statistically significant -LRB- p < 0.05 -RRB- .
25830055	0	Quercetin	0,9	IL-6	25,29	Quercetin	IL-6	MESH:D011794	3569	Chemical	Gene	Signals|compound|START_ENTITY Signals|compound|END_ENTITY	Quercetin Down-regulates IL-6 / STAT-3 Signals to Induce Mitochondrial-mediated Apoptosis in a Nonsmall - cell Lung-cancer Cell Line , A549 .
24397597	0	Quercetin	0,9	IQ_motif-containing_GTPase_activating_protein_1	84,131	Quercetin	IQ motif-containing GTPase activating protein 1	MESH:D011794	8826	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|expression expression|compound|END_ENTITY	Quercetin suppresses the proliferation of multiple_myeloma cells by down-regulating IQ_motif-containing_GTPase_activating_protein_1 expression and extracellular signal-regulated kinase activation .
22388943	0	Quercetin	0,9	LDL_receptor	23,35	Quercetin	LDL receptor	MESH:D011794	3949	Chemical	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|compound|END_ENTITY	Quercetin up-regulates LDL_receptor expression in HepG2 cells .
16792415	0	Quercetin	0,9	MAO-A	103,108	Quercetin	MAO-A	MESH:D011794	17161(Tax:10090)	Chemical	Gene	exerts|nsubj|START_ENTITY exerts|nmod|END_ENTITY	Quercetin as the active principle of Hypericum hircinum exerts a selective inhibitory activity against MAO-A : extraction , biological analysis , and computational study .
25687049	0	Quercetin	11,20	MDR1	58,62	Quercetin	MDR1	MESH:D011794	5243	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|Expression Expression|nmod|Gene Gene|compound|END_ENTITY	-LSB- Effect of Quercetin on Doxorubicin-induced Expression of MDR1 Gene in HL-60 Cells . -RSB-
21138867	0	Quercetin	0,9	Mcl-1	70,75	Quercetin	Mcl-1	MESH:D011794	4170	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|downregulation downregulation|nmod|END_ENTITY	Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of Bax .
20542118	0	Quercetin	0,9	Monocyte_Chemoattractant_Protein-1	21,55	Quercetin	Monocyte Chemoattractant Protein-1	MESH:D011794	24770(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|compound|END_ENTITY	Quercetin attenuates Monocyte_Chemoattractant_Protein-1 gene expression in glucose primed aortic endothelial cells through NF-kappaB and AP-1 .
20335952	0	Quercetin	0,9	P-glycoprotein	38,52	Quercetin	P-glycoprotein	MESH:D011794	5243	Chemical	Gene	START_ENTITY|nmod|modulator modulator|nmod|expression expression|amod|END_ENTITY	Quercetin as a potential modulator of P-glycoprotein expression and function in cells of human pancreatic_carcinoma line resistant to daunorubicin .
21466223	0	Quercetin	0,9	P-glycoprotein	118,132	Quercetin	P-glycoprotein	MESH:D011794	5243	Chemical	Gene	reduced|nsubj|START_ENTITY reduced|advcl|activating activating|dobj|END_ENTITY	Quercetin and rutin reduced the bioavailability of cyclosporine from Neoral , an immunosuppressant , through activating P-glycoprotein and CYP_3A4 .
7923555	0	Quercetin	0,9	P-glycoprotein	109,123	Quercetin	P-glycoprotein	MESH:D011794	5243	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|effect effect|dep|END_ENTITY	Quercetin potentiates the effect of adriamycin in a multidrug-resistant MCF-7 human breast-cancer cell line : P-glycoprotein as a possible target .
18628248	0	Quercetin	0,9	PKC_delta	55,64	Quercetin	PKC delta	MESH:D011794	5580	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	Quercetin inhibition of tumor invasion via suppressing PKC_delta / ERK/AP -1 - dependent matrix metalloproteinase-9 activation in breast_carcinoma cells .
25830055	0	Quercetin	0,9	STAT-3	30,36	Quercetin	STAT-3	MESH:D011794	6774	Chemical	Gene	Signals|compound|START_ENTITY Signals|compound|END_ENTITY	Quercetin Down-regulates IL-6 / STAT-3 Signals to Induce Mitochondrial-mediated Apoptosis in a Nonsmall - cell Lung-cancer Cell Line , A549 .
26218279	0	Quercetin	0,9	TLR2/4	72,78	Quercetin	TLR2/4	MESH:D011794	24088;21898	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|pathway pathway|compound|END_ENTITY	Quercetin protects mouse liver against CCl4-induced inflammation by the TLR2/4 and MAPK/NF-kB pathway .
21228504	0	Quercetin	0,9	VDR	19,22	Quercetin	VDR	MESH:D011794	7421	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|compound|END_ENTITY	Quercetin enhances VDR activity , leading to stimulation of its target gene expression in Caco-2 cells .
26902087	0	Quercetin	104,113	VDR	86,89	Quercetin	VDR	MESH:D011794	7421	Chemical	Gene	Activation|nmod|START_ENTITY Activation|compound|END_ENTITY	Quercetin Directly Interacts with Vitamin_D Receptor -LRB- VDR -RRB- : Structural Implication of VDR Activation by Quercetin .
11238180	0	Quercetin	0,9	androgen_receptor	54,71	Quercetin	androgen receptor	MESH:D011794	367	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Quercetin inhibits the expression and function of the androgen_receptor in LNCaP_prostate_cancer cells .
20551291	0	Quercetin	0,9	c-Fos	34,39	Quercetin	c-Fos	MESH:D011794	2353	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|expression expression|amod|END_ENTITY	Quercetin potentiates UVB-Induced c-Fos expression : implications for its use as a chemopreventive agent .
11562426	0	Quercetin	0,9	c-Jun_N-terminal_kinase	67,90	Quercetin	c-Jun N-terminal kinase	MESH:D011794	116554(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	Quercetin inhibits Shc - and phosphatidylinositol 3-kinase-mediated c-Jun_N-terminal_kinase activation by angiotensin_II in cultured rat aortic smooth muscle cells .
10082992	0	Quercetin	0,9	c-fos	84,89	Quercetin	c-fos	MESH:D011794	2353	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|ccomp|associated associated|nmod|increase increase|nmod|level level|amod|END_ENTITY	Quercetin inhibited DNA synthesis and induced apoptosis associated with increase in c-fos mRNA level and the upregulation of p21WAF1CIP1 mRNA and protein expression during liver regeneration after partial hepatectomy .
11104512	0	Quercetin	0,9	c-fos	19,24	Quercetin	c-fos	MESH:D011794	2353	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Quercetin inhibits c-fos , heat_shock protein , and glial fibrillary acidic protein expression in injured astrocytes .
14988445	0	Quercetin	0,9	cyclooxygenase-2	35,51	Quercetin	cyclooxygenase-2	MESH:D011794	5743	Chemical	Gene	metabolites|compound|START_ENTITY downregulate|nsubj|metabolites downregulate|dobj|transcription transcription|amod|END_ENTITY	Quercetin metabolites downregulate cyclooxygenase-2 transcription in human lymphocytes ex vivo but not in vivo .
21857970	0	Quercetin	0,9	cyclooxygenase-2	21,37	Quercetin	cyclooxygenase-2	MESH:D011794	5743	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Quercetin suppresses cyclooxygenase-2 expression and angiogenesis through inactivation of P300 signaling .
20548785	0	Quercetin	0,9	cysteine_string_protein	18,41	Quercetin	cysteine string protein	MESH:D011794	13002(Tax:10090)	Chemical	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Quercetin targets cysteine_string_protein -LRB- CSPalpha -RRB- and impairs synaptic transmission .
11414687	0	Quercetin	0,9	extracellular_signal-regulated_kinase	101,138	Quercetin	extracellular signal-regulated kinase	MESH:D011794	5594	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Quercetin inhibits matrix_metalloproteinase-1 expression in human vascular endothelial cells through extracellular_signal-regulated_kinase .
16211300	0	Quercetin	0,9	gadd45	18,24	Quercetin	gadd45	MESH:D011794	1647	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Quercetin induces gadd45 expression through a p53-independent pathway .
17433488	0	Quercetin	0,9	heme_oxygenase-1	87,103	Quercetin	heme oxygenase-1	MESH:D011794	3162	Chemical	Gene	protects|nsubj|START_ENTITY protects|advcl|inducing inducing|dobj|END_ENTITY	Quercetin protects human hepatocytes from ethanol-derived oxidative stress by inducing heme_oxygenase-1 via the MAPK/Nrf2 pathways .
9292787	0	Quercetin	0,9	interleukin_8	53,66	Quercetin	interleukin 8	MESH:D011794	3576	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|induction induction|nmod|expression expression|amod|END_ENTITY	Quercetin , a bioflavonoid , inhibits the induction of interleukin_8 and monocyte_chemoattractant_protein-1 expression by tumor_necrosis_factor-alpha in cultured human synovial cells .
22230496	0	Quercetin	1,10	leptin	19,25	Quercetin	leptin	MESH:D011794	3952	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|END_ENTITY	-LSB- Quercetin affects leptin and its receptor in human gastric_cancer MGC-803 cells and JAK-STAT pathway -RSB- .
11414687	0	Quercetin	0,9	matrix_metalloproteinase-1	19,45	Quercetin	matrix metalloproteinase-1	MESH:D011794	4312	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Quercetin inhibits matrix_metalloproteinase-1 expression in human vascular endothelial cells through extracellular_signal-regulated_kinase .
25596948	0	Quercetin	0,9	miR-146a	68,76	Quercetin	miR-146a	MESH:D011794	406938	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Quercetin inhibits proliferation and invasion acts by up-regulating miR-146a in human breast_cancer cells .
12934110	0	Quercetin	0,9	p27	19,22	Quercetin	p27	MESH:D011794	10671	Chemical	Gene	elevates|nsubj|START_ENTITY elevates|dobj|END_ENTITY	Quercetin elevates p27 -LRB- Kip1 -RRB- and arrests both primary and HPV16 E6/E7 transformed human keratinocytes in G1 .
19141295	0	Quercetin	0,9	paraoxonase_1	23,36	Quercetin	paraoxonase 1	MESH:D011794	84024(Tax:10116)	Chemical	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|amod|END_ENTITY	Quercetin up-regulates paraoxonase_1 gene expression with concomitant protection against LDL oxidation .
20728021	0	Quercetin	0,9	paraoxonase_1	23,36	Quercetin	paraoxonase 1	MESH:D011794	5444	Chemical	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|amod|END_ENTITY	Quercetin up-regulates paraoxonase_1 gene expression via sterol_regulatory_element_binding_protein_2 that translocates from the endoplasmic reticulum to the nucleus where it specifically interacts with sterol responsive element-like sequence in paraoxonase_1 promoter in HuH7 liver cells .
20728021	0	Quercetin	0,9	paraoxonase_1	245,258	Quercetin	paraoxonase 1	MESH:D011794	5444	Chemical	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|nmod|sterol_regulatory_element_binding_protein_2 sterol_regulatory_element_binding_protein_2|acl:relcl|translocates translocates|advcl|interacts interacts|nmod|sequence sequence|nmod|promoter promoter|amod|END_ENTITY	Quercetin up-regulates paraoxonase_1 gene expression via sterol_regulatory_element_binding_protein_2 that translocates from the endoplasmic reticulum to the nucleus where it specifically interacts with sterol responsive element-like sequence in paraoxonase_1 promoter in HuH7 liver cells .
21051700	0	Quercetin	0,9	peroxiredoxins_3_and_5	36,58	Quercetin	peroxiredoxins 3 and 5	MESH:D011794	10935;25824	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Quercetin induces the expression of peroxiredoxins_3_and_5 via the Nrf2/NRF1 transcription pathway .
23475436	0	Quercetin	0,9	ryanodine_receptor	41,59	Quercetin	ryanodine receptor	MESH:D011794	6261	Chemical	Gene	START_ENTITY|nmod|probe probe|nmod|activity activity|compound|END_ENTITY	Quercetin as a fluorescent probe for the ryanodine_receptor activity in Jurkat cells .
18419748	0	Quercetin	0,9	tissue-type_plasminogen_activator	18,51	Quercetin	tissue-type plasminogen activator	MESH:D011794	5327	Chemical	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Quercetin induced tissue-type_plasminogen_activator expression is mediated through Sp1 and p38_mitogen-activated_protein_kinase in human endothelial cells .
9292787	0	Quercetin	0,9	tumor_necrosis_factor-alpha	120,147	Quercetin	tumor necrosis factor-alpha	MESH:D011794	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Quercetin , a bioflavonoid , inhibits the induction of interleukin_8 and monocyte_chemoattractant_protein-1 expression by tumor_necrosis_factor-alpha in cultured human synovial cells .
24612139	0	Quercetin	0,9	tumor_necrosis_factor-related_apoptosis-inducing_ligand	39,94	Quercetin	tumor necrosis factor-related apoptosis-inducing ligand	MESH:D011794	8743	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|effect effect|nmod|END_ENTITY	Quercetin enhances apoptotic effect of tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- in ovarian_cancer cells through reactive oxygen species -LRB- ROS -RRB- mediated CCAAT_enhancer-binding_protein_homologous_protein -LRB- CHOP -RRB- - death receptor 5 pathway .
24216107	0	Quercetin-3-O-glucuronide	0,25	ABCA1	34,39	Quercetin-3-O-glucuronide	ABCA1	MESH:C443401	11303(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Quercetin-3-O-glucuronide induces ABCA1 expression by LXRa activation in murine macrophages .
11925453	0	Quercetin-3-glucoside	0,21	SGLT1	60,65	Quercetin-3-glucoside	SGLT1	MESH:C016527	25552(Tax:10116)	Chemical	Gene	transported|nsubjpass|START_ENTITY transported|nmod|END_ENTITY	Quercetin-3-glucoside is transported by the glucose carrier SGLT1 across the brush border membrane of rat small intestine .
25349780	0	Quercetin-3-glucoside	0,21	low-density_lipoprotein_receptor	32,64	Quercetin-3-glucoside	low-density lipoprotein receptor	MESH:C016527	3949	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Quercetin-3-glucoside increases low-density_lipoprotein_receptor -LRB- LDLR -RRB- expression , attenuates proprotein_convertase_subtilisin / kexin_9 -LRB- PCSK9 -RRB- secretion , and stimulates LDL uptake by Huh7 human hepatocytes in culture .
15486491	0	Quetiapine	0,10	FGF-2	21,26	Quetiapine	FGF-2	MESH:C069541	54250(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Quetiapine regulates FGF-2 and BDNF expression in the hippocampus of animals treated with MK-801 .
11872258	0	Quetiapine	0,10	brain-derived_neurotrophic_factor	68,101	Quetiapine	brain-derived neurotrophic factor	MESH:C069541	24225(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|decrease decrease|nmod|expression expression|amod|END_ENTITY	Quetiapine attenuates the immobilization stress-induced decrease of brain-derived_neurotrophic_factor expression in rat hippocampus .
16115734	0	Quetiapine	0,10	heme_oxygenase-2	49,65	Quetiapine	heme oxygenase-2	MESH:C069541	79239(Tax:10116)	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|amod|END_ENTITY	Quetiapine and venlafaxine synergically regulate heme_oxygenase-2 protein expression in the hippocampus of stressed rats .
22008251	0	Quetiapine	0,10	neuropeptide_Y	19,33	Quetiapine	neuropeptide Y	MESH:C069541	4852	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|END_ENTITY	Quetiapine affects neuropeptide_Y and corticotropin-releasing_hormone in cerebrospinal fluid from schizophrenia patients : relationship to depression and anxiety_symptoms and to treatment response .
15220251	0	Quinapril	0,9	ACE	14,17	Quinapril	ACE	MESH:C041125	1636	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Quinapril , an ACE inhibitor , reduces markers of oxidative stress in the metabolic_syndrome .
2068835	0	Quinapril	0,9	ACE	35,38	Quinapril	ACE	MESH:C041125	1636	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Quinapril : a new second-generation ACE inhibitor .
11800416	0	Quinapril	0,9	angiotensin-converting_enzyme	39,68	Quinapril	angiotensin-converting enzyme	MESH:C041125	1636	Chemical	Gene	START_ENTITY|nmod|affinity affinity|nmod|END_ENTITY	Quinapril with high affinity to tissue angiotensin-converting_enzyme reduces restenosis after percutaneous transcatheter coronary intervention .
9370386	0	Quinapril	0,9	c-Myc	19,24	Quinapril	c-Myc	MESH:C041125	24577(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Quinapril inhibits c-Myc expression and normalizes smooth muscle cell proliferation in spontaneously hypertensive rats .
9176845	0	Quinapril	0,9	endothelin-1	26,38	Quinapril	endothelin-1	MESH:C041125	24323(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|amod|END_ENTITY	Quinapril decreases renal endothelin-1 expression and synthesis in a normotensive model of immune-complex nephritis .
19435660	0	Quinazolin-4-piperidin-4-methyl_sulfamide	0,41	PC-1	42,46	Quinazolin-4-piperidin-4-methyl sulfamide	PC-1	null	5167	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Quinazolin-4-piperidin-4-methyl_sulfamide PC-1 inhibitors : alleviating hERG interactions through structure based design .
1613755	0	Quinazoline	0,11	thymidylate_synthase	23,43	Quinazoline	thymidylate synthase	CHEBI:36621	22171(Tax:10090)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Quinazoline antifolate thymidylate_synthase inhibitors : difluoro-substituted_benzene ring analogues .
2066994	0	Quinazoline	0,11	thymidylate_synthase	23,43	Quinazoline	thymidylate synthase	CHEBI:36621	22171(Tax:10090)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Quinazoline antifolate thymidylate_synthase inhibitors : bridge modifications and conformationally restricted analogues in the C2-methyl series .
2231606	0	Quinazoline	0,11	thymidylate_synthase	23,43	Quinazoline	thymidylate synthase	CHEBI:36621	22171(Tax:10090)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Quinazoline antifolate thymidylate_synthase inhibitors : alkyl , substituted alkyl , and aryl substituents in the C2 position .
2231607	0	Quinazoline	0,11	thymidylate_synthase	23,43	Quinazoline	thymidylate synthase	CHEBI:36621	22171(Tax:10090)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Quinazoline antifolate thymidylate_synthase inhibitors : 2 ' - fluoro-N10-propargyl-5 ,8 - dideazafolic_acid and derivatives with modifications in the C2 position .
2231608	0	Quinazoline	0,11	thymidylate_synthase	23,43	Quinazoline	thymidylate synthase	CHEBI:36621	22171(Tax:10090)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Quinazoline antifolate thymidylate_synthase inhibitors : benzoyl ring modifications in the C2-methyl series .
2918503	0	Quinazoline	0,11	thymidylate_synthase	23,43	Quinazoline	thymidylate synthase	CHEBI:36621	22171(Tax:10090)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Quinazoline antifolate thymidylate_synthase inhibitors : nitrogen , oxygen , sulfur , and chlorine substituents in the C2 position .
7495479	0	Quinazoline	0,11	thymidylate_synthase	12,32	Quinazoline	thymidylate synthase	CHEBI:36621	22171(Tax:10090)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Quinazoline thymidylate_synthase inhibitors : methods for assessing the contribution of polyglutamation to their in vitro activity .
8100167	0	Quinidine	0,9	CYP2D6	90,96	Quinidine	CYP2D6	MESH:D011802	1565	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|genotypes genotypes|compound|END_ENTITY	Quinidine inhibition of debrisoquine S -LRB- + -RRB- -4 - and 7-hydroxylations in Chinese of different CYP2D6 genotypes .
10976551	0	Quinidine	0,9	CYP3A4	25,31	Quinidine	CYP3A4	MESH:D011802	1576	Chemical	Gene	START_ENTITY|nmod|probe probe|nmod|activity activity|compound|END_ENTITY	Quinidine as a probe for CYP3A4 activity : intrasubject variability and lack of correlation with probe-based assays for CYP1A2 , CYP2C9 , CYP2C19 , and CYP2D6 .
1761076	0	Quinidine	0,9	debrisoquine_4-hydroxylase	107,133	Quinidine	debrisoquine 4-hydroxylase	MESH:D011802	1565	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|routes routes|acl:relcl|involve involve|xcomp|END_ENTITY	Quinidine but not quinine inhibits in man the oxidative metabolic routes of methoxyphenamine which involve debrisoquine_4-hydroxylase .
14973303	0	Quinidine	0,9	p-glycoprotein	37,51	Quinidine	p-glycoprotein	MESH:D011802	5243	Chemical	Gene	START_ENTITY|nmod|probe probe|nmod|role role|nmod|END_ENTITY	Quinidine as a probe for the role of p-glycoprotein in the intestinal absorption and clinical effects of fentanyl .
1899114	0	Quinidine	0,9	prolactin	19,28	Quinidine	prolactin	MESH:D011802	24683(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|compound|END_ENTITY	Quinidine inhibits prolactin secretion induced by thyrotropin-releasing_hormone , high medium potassium or hyposmolarity in GH4C1 cells .
8788453	0	Quinine	0,7	tumor_necrosis_factor	28,49	Quinine	tumor necrosis factor	MESH:D011803	21926(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|nmod|END_ENTITY	Quinine inhibits release of tumor_necrosis_factor , apoptosis , necrosis and mortality in a murine model of septic_liver_failure .
8179913	0	Quinine	0,7	tumor_necrosis_factor-alpha	31,58	Quinine	tumor necrosis factor-alpha	MESH:D011803	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|nmod|END_ENTITY	Quinine inhibits production of tumor_necrosis_factor-alpha from human alveolar_macrophages .
25611347	0	Quinofuracins_A-E	0,17	PF1444	68,74	Quinofuracins A-E	PF1444	null	1469320(Tax:186497)	Chemical	Gene	START_ENTITY|acl|Produced Produced|nmod|END_ENTITY	Quinofuracins_A-E , Produced by the Fungus Staphylotrichum boninense PF1444 , Show p53-Dependent Growth Suppression .
25757085	0	Quinolinate	33,44	RAGE	99,103	Quinolinate	RAGE	MESH:D017378	81722(Tax:10116)	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|appos|END_ENTITY	Modeling the Interaction between Quinolinate and the Receptor_for_Advanced_Glycation_End_Products -LRB- RAGE -RRB- : Relevance for Early Neuropathological Processes .
1495009	0	Quinoline	0,9	thymidylate_synthase	21,41	Quinoline	thymidylate synthase	MESH:C037219	22171(Tax:10090)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Quinoline antifolate thymidylate_synthase inhibitors : variation of the C2 - and C4-substituents .
22572932	0	Quinoline-3-carboxamide	0,23	cholesteryl_ester_transfer_protein	49,83	Quinoline-3-carboxamide	cholesteryl ester transfer protein	MESH:C541322	1071	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Quinoline-3-carboxamide derivatives as potential cholesteryl_ester_transfer_protein inhibitors .
9871745	0	Quinolines	0,10	5-lipoxygenase	21,35	Quinolines	5-lipoxygenase	MESH:D011804	240	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Quinolines as potent 5-lipoxygenase inhibitors : synthesis and biological profile of L-746 ,530 .
19656678	0	Quinolines	0,10	PDE4	63,67	Quinolines	PDE4	MESH:D011804	5141	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Quinolines as a novel structural class of potent and selective PDE4 inhibitors .
26598832	0	Quinolinic_Acid	26,41	QPRT	69,73	Quinolinic Acid	QPRT	MESH:D017378	67375(Tax:10090)	Chemical	Gene	Knockout|compound|START_ENTITY Knockout|appos|END_ENTITY	True_Niacin_Deficiency in Quinolinic_Acid Phosphoribosyltransferase -LRB- QPRT -RRB- Knockout Mice .
9355959	0	Quinolinic_acid	0,15	IFN-gamma	58,67	Quinolinic acid	IFN-gamma	MESH:D017378	3458	Chemical	Gene	production|amod|START_ENTITY stimulated|nsubj|production stimulated|nmod|END_ENTITY	Quinolinic_acid production by macrophages stimulated with IFN-gamma , TNF-alpha , and IFN-alpha .
26738727	0	Quinolinic_acid	0,15	RTP801	77,83	Quinolinic acid	RTP801	MESH:D017378	140942(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|compound|END_ENTITY	Quinolinic_acid induces cell apoptosis in PC12 cells through HIF-1-dependent RTP801 activation .
1672145	0	Quinolinic_acid	0,15	somatostatin	27,39	Quinolinic acid	somatostatin	MESH:D017378	24797(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	Quinolinic_acid stimulates somatostatin gene expression in cultured rat cortical neurons .
10937733	0	Quinolones	0,10	gonadotropin_releasing_hormone	14,44	Quinolones	gonadotropin releasing hormone	MESH:D015363	2796	Chemical	Gene	START_ENTITY|nmod|antagonists antagonists|amod|END_ENTITY	Quinolones as gonadotropin_releasing_hormone -LRB- GnRH -RRB- antagonists : simultaneous optimization of the C -LRB- 3 -RRB- - aryl and C -LRB- 6 -RRB- - substituents .
10714272	0	Quinone	0,7	NQO1	19,23	Quinone	NQO1	MESH:C004532	1728	Chemical	Gene	reductase|amod|START_ENTITY reductase|appos|END_ENTITY	Quinone reductase -LRB- NQO1 -RRB- , a sensitive redox indicator , is increased in Alzheimer 's _ disease .
15151706	0	Quinone	0,7	NQO1	24,28	Quinone	NQO1	MESH:C004532	1728	Chemical	Gene	polymorphism|advmod|START_ENTITY polymorphism|appos|END_ENTITY	Quinone oxidoreductase -LRB- NQO1 -RRB- gene polymorphism -LRB- 609C/T -RRB- may be associated with tardive_dyskinesia , but not with the development of schizophrenia .
17644186	0	Quinone	0,7	NQO1	24,28	Quinone	NQO1	MESH:C004532	1728	Chemical	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	Quinone oxidoreductase -LRB- NQO1 -RRB- gene polymorphism may not confer a susceptibility to mood_disorders .
9530167	0	Quinones	0,8	gamma-glutamyl_transpeptidase	18,47	Quinones	gamma-glutamyl transpeptidase	MESH:D011809	116568(Tax:10116)	Chemical	Gene	increase|nsubj|START_ENTITY increase|dobj|expression expression|amod|END_ENTITY	Quinones increase gamma-glutamyl_transpeptidase expression by multiple mechanisms in rat lung epithelial cells .
9518687	0	Quinpirole	0,10	fos	35,38	Quinpirole	fos	MESH:D019257	314322(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|compound|END_ENTITY	Quinpirole attenuates the striatal fos expression induced by escape behavior .
1688963	0	Quipazine	0,9	renin	20,25	Quipazine	renin	MESH:D011814	24715(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|release release|compound|END_ENTITY	Quipazine increases renin release by a peripheral hemodynamic mechanism .
11045470	0	R-106578	114,122	ACAT	97,101	R-106578	ACAT	null	6646	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|appos|END_ENTITY	Enantioselective synthesis of the key intermediate of the acyl-CoA : _ cholesterol_acyltransferase -LRB- ACAT -RRB- inhibitor -LRB- R-106578 -RRB- using 2,2 ' - bis -LRB- diphenylphosphino -RRB- -1,1 ' - binaphthyl _ -LRB- BINAP -RRB- - Ru -LRB- OAc -RRB- 2 as a catalyst .
15888346	0	R-130823	31,39	IL-6	51,55	R-130823	IL-6	MESH:C497778	3569	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|production production|amod|END_ENTITY	Novel p38_MAP_kinase inhibitor R-130823 suppresses IL-6 , IL-8 and MMP-13 production in spheroid culture of human synovial_sarcoma cell line SW_982 .
23911580	0	R-568	73,78	ECE-1	46,51	R-568	ECE-1	MESH:C107873	94204(Tax:10116)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of endothelin-converting_enzyme-1 -LRB- ECE-1 -RRB- by the calcimimetic R-568 .
23911580	0	R-568	73,78	endothelin-converting_enzyme-1	14,44	R-568	endothelin-converting enzyme-1	MESH:C107873	94204(Tax:10116)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of endothelin-converting_enzyme-1 -LRB- ECE-1 -RRB- by the calcimimetic R-568 .
17200160	0	R-568	17,22	vitamin_D_receptor	33,51	R-568	vitamin D receptor	MESH:C107873	24873(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	The calcimimetic R-568 increases vitamin_D_receptor expression in rat parathyroid glands .
8990505	0	R-85355	8,15	5-lipoxygenase	40,54	R-85355	5-lipoxygenase	MESH:C106484	240	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Topical R-85355 , a potent and selective 5-lipoxygenase inhibitor , fails to improve psoriasis .
17975552	0	R-Roscovitine	0,13	p53	46,49	R-Roscovitine	p53	MESH:C104586	7157	Chemical	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	R-Roscovitine simultaneously targets both the p53 and NF-kappaB pathways and causes potentiation of apoptosis : implications in cancer therapy .
18090435	0	R-flurbiprofen	92,106	Abeta	44,49	R-flurbiprofen	Abeta	CHEBI:38666	351	Chemical	Gene	administration|nmod|START_ENTITY levels|nmod|administration levels|compound|END_ENTITY	Safety , tolerability , pharmacokinetics , and Abeta levels after short-term administration of R-flurbiprofen in healthy elderly individuals .
3877668	0	R-goitrin	19,28	epoxide_hydratase	93,110	R-goitrin	epoxide hydratase	null	65030(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of dietary R-goitrin on hepatic and intestinal glutathione_S-transferase , microsomal epoxide_hydratase and ethoxycoumarin_O-deethylase activities in the rat .
26206334	0	R-ketorolac	0,11	Cdc42	20,25	R-ketorolac	Cdc42	null	998	Chemical	Gene	Targets|nsubj|START_ENTITY Targets|dobj|END_ENTITY	R-ketorolac Targets Cdc42 and Rac1 and Alters Ovarian_Cancer Cell Behaviors Critical for Invasion and Metastasis .
26206334	0	R-ketorolac	0,11	Cdc42	20,25	R-ketorolac	Cdc42	null	998	Chemical	Gene	Targets|nsubj|START_ENTITY Targets|dobj|END_ENTITY	R-ketorolac Targets Cdc42 and Rac1 and Alters Ovarian_Cancer Cell Behaviors Critical for Invasion and Metastasis .
3156909	0	R011-1163	61,70	MAO_A	33,38	R011-1163	MAO A	null	4128	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	A controlled study of a specific MAO_A reversible inhibitor -LRB- R011-1163 -RRB- and amitriptyline in depressive_illness .
8360100	0	R1128	0,5	estrogen-receptor	38,55	R1128	estrogen-receptor	null	2099	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|compound|END_ENTITY	R1128 substances , novel non-steroidal estrogen-receptor antagonists produced by a Streptomyces .
8360101	0	R1128	0,5	estrogen-receptor	38,55	R1128	estrogen-receptor	null	2099	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|compound|END_ENTITY	R1128 substances , novel non-steroidal estrogen-receptor antagonists produced by a Streptomyces .
11598498	0	R121920	47,54	CRF1	31,35	R121920	CRF1	MESH:C521823	58959(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|antagonist antagonist|compound|END_ENTITY	Neuroprotective effects of the CRF1 antagonist R121920 after permanent focal ischemia in the rat .
24390424	0	R1507	55,60	IGF-1R	87,93	R1507	IGF-1R	null	3480	Chemical	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	Phase 1b study of safety , tolerability and efficacy of R1507 , a monoclonal antibody to IGF-1R in combination with multiple standard oncology regimens in patients with advanced solid malignancies .
19295308	0	R348	24,28	JAK3	8,12	R348	JAK3	null	25326(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	A novel JAK3 inhibitor , R348 , attenuates chronic airway allograft rejection .
20145120	0	R428	0,4	Axl	46,49	R428	Axl	null	558	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|kinase kinase|compound|END_ENTITY	R428 , a selective small molecule inhibitor of Axl kinase , blocks_tumor spread and prolongs survival in models of metastatic breast_cancer .
8674801	0	R44S-PSTI	96,105	pancreatic_secretory_trypsin_inhibitor	56,94	R44S-PSTI	pancreatic secretory trypsin inhibitor	null	6690	Chemical	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	The protective effects of long-acting recombinant human pancreatic_secretory_trypsin_inhibitor -LRB- R44S-PSTI -RRB- in a rat model of cerulein-induced pancreatitis .
20549497	0	R483	57,61	CYP2C19	65,72	R483	CYP2C19	null	1557	Chemical	Gene	START_ENTITY|appos|substrate substrate|compound|END_ENTITY	Influence of CYP2C19 genotype on the pharmacokinetics of R483 , a CYP2C19 substrate , in healthy subjects and type 2 diabetes patients .
3199817	0	R5020	80,85	progesterone_receptor	24,45	R5020	progesterone receptor	MESH:D011397	5241	Chemical	Gene	progestin|appos|START_ENTITY presence|nmod|progestin Transformation|nmod|presence Transformation|nmod|END_ENTITY	Transformation of human progesterone_receptor in the presence of the progestin -LRB- R5020 -RRB- and the antiprogestin -LRB- RU486 -RRB- .
17588539	0	R59022	35,41	diacylglycerol_kinase	2,23	R59022	diacylglycerol kinase	MESH:C047505	8526	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	A diacylglycerol_kinase inhibitor , R59022 , stimulates glucose transport through a MKK3/6-p 38 signaling pathway in skeletal muscle cells .
23949095	0	R59022	73,79	diacylglycerol_kinase	40,61	R59022	diacylglycerol kinase	MESH:C047505	1607	Chemical	Gene	inhibitors|dobj|START_ENTITY inhibitors|nsubj|Evaluations Evaluations|nmod|selectivities selectivities|nmod|END_ENTITY	Evaluations of the selectivities of the diacylglycerol_kinase inhibitors R59022 and R59949 among diacylglycerol_kinase isozymes using a new non-radioactive assay method .
23949095	0	R59022	73,79	diacylglycerol_kinase	97,118	R59022	diacylglycerol kinase	MESH:C047505	1607	Chemical	Gene	inhibitors|dobj|START_ENTITY inhibitors|nmod|isozymes isozymes|amod|END_ENTITY	Evaluations of the selectivities of the diacylglycerol_kinase inhibitors R59022 and R59949 among diacylglycerol_kinase isozymes using a new non-radioactive assay method .
22178087	0	RAD001	34,40	MEK	46,49	RAD001	MEK	MESH:C107135	5609	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Synergistic anti-tumor effects of RAD001 with MEK inhibitors in neuroendocrine_tumors : a potential mechanism of therapeutic limitation of mTOR inhibitor .
16443261	0	RAD001	52,58	mTOR	37,41	RAD001	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|Effects Effects|nmod|treatment treatment|nmod|END_ENTITY	Effects of a combined treatment with mTOR inhibitor RAD001 and tamoxifen in vitro on growth and apoptosis of human cancer cells .
18704419	0	RAD001	68,74	mTOR	21,25	RAD001	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|trial trial|nmod|END_ENTITY	A pilot trial of the mTOR -LRB- mammalian_target_of_rapamycin -RRB- inhibitor RAD001 in patients with advanced B-CLL .
19306412	0	RAD001	64,70	mTOR	49,53	RAD001	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|study study|nmod|regimen regimen|nmod|inhibitor inhibitor|compound|END_ENTITY	A phase 2 study with a daily regimen of the oral mTOR inhibitor RAD001 -LRB- everolimus -RRB- in patients with metastatic clear_cell_renal_cell_cancer .
19424940	0	RAD001	125,131	mTOR	98,102	RAD001	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	everolimus|appos|START_ENTITY everolimus|amod|END_ENTITY	Novel and evolving therapies in the treatment of malignant phaeochromocytoma : experience with the mTOR inhibitor everolimus -LRB- RAD001 -RRB- .
19496707	0	RAD001	12,18	mTOR	24,28	RAD001	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	Everolimus|appos|START_ENTITY Everolimus|dep|inhibitor inhibitor|compound|END_ENTITY	Everolimus -LRB- RAD001 -RRB- : an mTOR inhibitor for the treatment of metastatic_renal_cell_carcinoma .
20204306	0	RAD001	0,6	mTOR	63,67	RAD001	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	offers|nsubj|START_ENTITY offers|nmod|inhibition inhibition|nmod|END_ENTITY	RAD001 offers a therapeutic intervention through inhibition of mTOR as a potential strategy for esophageal_cancer .
20360931	0	RAD001	82,88	mTOR	55,59	RAD001	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	Everolimus|appos|START_ENTITY Everolimus|amod|END_ENTITY	Biomarker Development for the Clinical Activity of the mTOR Inhibitor Everolimus -LRB- RAD001 -RRB- : Processes , Limitations , and Further Proposals .
21334199	0	RAD001	105,111	mTOR	89,93	RAD001	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Lack of compensatory pAKT activation and eIF4E phosphorylation of lymphoma cells towards mTOR inhibitor , RAD001 .
21415218	0	RAD001	38,44	mTOR	11,15	RAD001	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	Effects|appos|START_ENTITY Effects|nmod|everolimus everolimus|compound|END_ENTITY	Effects of mTOR inhibitor everolimus -LRB- RAD001 -RRB- on bladder_cancer cells .
22178087	0	RAD001	34,40	mTOR	138,142	RAD001	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|mechanism mechanism|nmod|limitation limitation|nmod|inhibitor inhibitor|compound|END_ENTITY	Synergistic anti-tumor effects of RAD001 with MEK inhibitors in neuroendocrine_tumors : a potential mechanism of therapeutic limitation of mTOR inhibitor .
22829152	0	RAD001	32,38	mTOR	4,8	RAD001	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	everolimus|appos|START_ENTITY inhibitor|appos|everolimus inhibitor|compound|END_ENTITY	The mTOR inhibitor , everolimus -LRB- RAD001 -RRB- , overcomes resistance to imatinib in quiescent Ph-positive acute_lymphoblastic_leukemia cells .
23155392	0	RAD001	0,6	mTOR	49,53	RAD001	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|xcomp|inhibit inhibit|dobj|signaling signaling|compound|END_ENTITY	RAD001 enhances the potency of BEZ235 to inhibit mTOR signaling and tumor growth .
23588885	5	RAD001	664,670	mTOR	870,874	RAD001	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	proliferation|nummod|START_ENTITY observed|nsubjpass|proliferation observed|nmod|inhibition inhibition|compound|END_ENTITY	RAD001 significantly inhibits proliferation of CCA cell lines , however , a concentration-dependent and isoform specific feedback activation of the three AKT isoforms -LRB- AKT1 , AKT2 and AKT3 -RRB- was observed after mTOR inhibition .
24716234	0	RAD001	79,85	mTOR	52,56	RAD001	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	everolimus|appos|START_ENTITY inhibitor|dobj|everolimus inhibitor|nsubj|results results|nmod|trial trial|nmod|END_ENTITY	Long-term results of the phase II trial of the oral mTOR inhibitor everolimus -LRB- RAD001 -RRB- in relapsed or refractory Waldenstrom_Macroglobulinemia .
25026292	0	RAD001	22,28	mTOR	93,97	RAD001	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	BEZ235|compound|START_ENTITY therapy|nmod|BEZ235 overcomes|nsubj|therapy overcomes|ccomp|immortalized immortalized|nmod|inhibition inhibition|compound|END_ENTITY	Combined therapy with RAD001 e BEZ235 overcomes resistance of PET immortalized cell lines to mTOR inhibition .
25611229	0	RAD001	57,63	mTOR	30,34	RAD001	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	Everolimus|appos|START_ENTITY Everolimus|compound|END_ENTITY	SWOG S0722 : Phase II Study of mTOR Inhibitor Everolimus -LRB- RAD001 -RRB- in Advanced_Malignant_Pleural_Mesothelioma -LRB- MPM -RRB- .
25777454	0	RAD001	103,109	mTOR	76,80	RAD001	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	everolimus|appos|START_ENTITY everolimus|amod|END_ENTITY	Successful control of heavily pretreated metastatic gastric_cancer with the mTOR inhibitor everolimus -LRB- RAD001 -RRB- in a patient with PIK3CA mutation and pS6 overexpression .
25886409	0	RAD001	103,109	mTOR	76,80	RAD001	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	everolimus|appos|START_ENTITY everolimus|amod|END_ENTITY	Successful control of heavily pretreated metastatic gastric_cancer with the mTOR inhibitor everolimus -LRB- RAD001 -RRB- in a patient with PIK3CA mutation and pS6 overexpression .
26861608	0	RAD001	32,38	mTOR	44,48	RAD001	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	everolimus|appos|START_ENTITY everolimus|appos|plus plus|compound|END_ENTITY	A phase II study of everolimus -LRB- RAD001 -RRB- , an mTOR inhibitor plus CHOP for newly diagnosed peripheral_T-cell_lymphomas .
27050281	0	RAD001	30,36	mTOR	86,90	RAD001	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	efficacy|nmod|START_ENTITY enhances|dobj|efficacy enhances|advcl|abrogating abrogating|dobj|phosphorylation phosphorylation|compound|END_ENTITY	CGP57380 enhances efficacy of RAD001 in non-small_cell_lung_cancer through abrogating mTOR inhibition-induced phosphorylation of eIF4E and activating mitochondrial apoptotic pathway .
27063582	0	RAD001	0,6	mTOR	82,86	RAD001	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|advcl|inhibiting inhibiting|dobj|END_ENTITY	RAD001 -LRB- everolimus -RRB- attenuates experimental autoimmune neuritis by inhibiting the mTOR pathway , elevating Akt activity and polarizing M2 macrophages .
20941539	0	RAD001	56,62	mammalian_target_of_rapamycin	4,33	RAD001	mammalian target of rapamycin	MESH:C107135	2475	Chemical	Gene	everolimus|appos|START_ENTITY everolimus|amod|END_ENTITY	The mammalian_target_of_rapamycin inhibitor everolimus -LRB- RAD001 -RRB- in early breast_cancer : results of a pre-operative study .
26109203	0	RAP-011	0,7	lefty1	99,105	RAP-011	lefty1	null	30145(Tax:7955)	Chemical	Gene	improves|nsubj|START_ENTITY improves|nmod|END_ENTITY	RAP-011 improves erythropoiesis in zebrafish model of Diamond-Blackfan_anemia through antagonizing lefty1 .
20959489	0	RAP80	0,5	BRCA1	28,33	RAP80	BRCA1	null	373983(Tax:9031)	Chemical	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	RAP80 acts independently of BRCA1 in repair of topoisomerase II poison-induced DNA damage .
22885111	0	RAPADILINO	0,10	RECQL4	11,17	RAPADILINO	RECQL4	null	9401	Chemical	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	RAPADILINO RECQL4 mutant protein lacks helicase and ATPase activity .
23248408	0	RBx-0128	25,33	dipeptidyl_peptidase-IV	58,81	RBx-0128	dipeptidyl peptidase-IV	null	25253(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Biological evaluation of RBx-0128 , a potent and selective dipeptidyl_peptidase-IV inhibitor in type 2 diabetes genetic model .
1682039	0	RC-3095	67,74	RC-160	114,120	RC-3095	RC-160	MESH:C071363	3240093(Tax:185588)	Chemical	Gene	dose|amod|START_ENTITY dose|nmod|END_ENTITY	Inhibitory effect of bombesin/gastrin-releasing _ peptide antagonist RC-3095 and high dose of somatostatin analogue RC-160 on nitrosamine-induced pancreatic_cancers in hamsters .
8313359	0	RC-3095	50,57	bombesin	21,29	RC-3095	bombesin	MESH:C071363	2922	Chemical	Gene	antagonist|dobj|START_ENTITY antagonist|nsubj|effect effect|nmod|receptor receptor|compound|END_ENTITY	Inhibitory effect of bombesin receptor antagonist RC-3095 on the growth of human pancreatic_cancer cells in vivo and in vitro .
21953084	0	RC-3095	21,28	gastrin-releasing_peptide_receptor	51,85	RC-3095	gastrin-releasing peptide receptor	MESH:C071363	14829(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|antagonist antagonist|nmod|END_ENTITY	Protective effect of RC-3095 , an antagonist of the gastrin-releasing_peptide_receptor , in experimental arthritis .
24326363	0	RC-3095	0,7	gastrin-releasing_peptide_receptor	11,45	RC-3095	gastrin-releasing peptide receptor	MESH:C071363	2925	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	RC-3095 , a gastrin-releasing_peptide_receptor antagonist , synergizes with gemcitabine to inhibit the growth of human pancreatic_cancer CFPAC-1 in vitro and in vivo .
12540016	0	RDP58	0,5	TNF	24,27	RDP58	TNF	MESH:C092373	21926(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	RDP58 , a locally active TNF inhibitor , is effective in the dextran sulphate mouse model of chronic_colitis .
2438401	0	REV-5901	39,47	5-lipoxygenase	13,27	REV-5901	5-lipoxygenase	MESH:C049740	240	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Effects of a 5-lipoxygenase inhibitor , REV-5901 , on leukotriene and histamine release from human lung tissue in-vitro .
18628614	0	RFRP-3	4,10	GHRH	31,35	RFRP-3	GHRH	null	29446(Tax:10116)	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|expression expression|compound|END_ENTITY	Rat RFRP-3 alters hypothalamic GHRH expression and growth hormone secretion but does not affect KiSS-1 gene expression or the onset of puberty in male rats .
22753001	0	RG7112	38,44	MDM2	23,27	RG7112	MDM2	MESH:C579783	4193	Chemical	Gene	START_ENTITY|nsubj|testing testing|nmod|inhibitor inhibitor|compound|END_ENTITY	Initial testing of the MDM2 inhibitor RG7112 by the Pediatric Preclinical Testing Program .
24309210	2	RG7112	245,251	MDM2	270,274	RG7112	MDM2	MESH:C579783	4193	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	To assess the influence of the p53 regulatory pathway further , we studied the effect of RG7112 , a small molecule MDM2 antagonist that activates p53 by preventing its interaction with MDM2 , on normal megakaryocytopoiesis and platelet production .
24900694	0	RG7112	13,19	MDM2	38,42	RG7112	MDM2	MESH:C579783	4193	Chemical	Gene	Discovery|nmod|START_ENTITY Discovery|dep|Inhibitor Inhibitor|compound|END_ENTITY	Discovery of RG7112 : A Small-Molecule MDM2 Inhibitor in Clinical Development .
26279182	0	RG7112	0,6	MDM2	38,42	RG7112	MDM2	MESH:C579783	4193	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|nmod|END_ENTITY	RG7112 , a Small-Molecule Inhibitor of MDM2 , Enhances Trabectedin Response in Soft Tissue Sarcomas .
26279182	0	RG7112	0,6	MDM2	38,42	RG7112	MDM2	MESH:C579783	4193	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|nmod|END_ENTITY	RG7112 , a Small-Molecule Inhibitor of MDM2 , Enhances Trabectedin Response in Soft Tissue Sarcomas .
26288114	0	RG7112	0,6	MDM2	38,42	RG7112	MDM2	MESH:C579783	4193	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|nmod|END_ENTITY	RG7112 , a Small-Molecule Inhibitor of MDM2 , Enhances Trabectedin Response in Soft Tissue Sarcomas .
26459177	0	RG7112	32,38	MDM2	57,61	RG7112	MDM2	MESH:C579783	4193	Chemical	Gene	Trial|nmod|START_ENTITY Results|nmod|Trial Results|appos|Antagonist Antagonist|compound|END_ENTITY	Results of the Phase I Trial of RG7112 , a Small-Molecule MDM2 Antagonist in Leukemia .
23084521	0	RG7112	30,36	P53	44,47	RG7112	P53	MESH:C579783	7157	Chemical	Gene	START_ENTITY|nmod|pathway pathway|compound|END_ENTITY	Effect of the MDM2 antagonist RG7112 on the P53 pathway in patients with MDM2-amplified , well-differentiated or dedifferentiated liposarcoma : an exploratory proof-of-mechanism study .
23400593	0	RG7112	31,37	p53	48,51	RG7112	p53	MESH:C579783	7157	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	MDM2 small-molecule antagonist RG7112 activates p53 signaling and regresses human tumors in preclinical cancer models .
2459008	0	RGH-2958	75,83	thrombin	55,63	RGH-2958	thrombin	MESH:C035202	100009146(Tax:9986)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Experimental oral anticoagulation by a directly acting thrombin inhibitor -LRB- RGH-2958 -RRB- .
1815218	0	RGH_2202	74,82	thyrotropin-releasing_hormone	34,63	RGH 2202	thyrotropin-releasing hormone	MESH:C055448	25569(Tax:10116)	Chemical	Gene	analogue|appos|START_ENTITY analogue|amod|END_ENTITY	Behavioral changes induced by the thyrotropin-releasing_hormone analogue , RGH_2202 .
6280740	0	RHC_3659	0,8	angiotensin_converting_enzyme	30,59	RHC 3659	angiotensin converting enzyme	MESH:C034144	1636	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	RHC_3659 : a new orally active angiotensin_converting_enzyme inhibitor in normal volunteers .
3796224	0	RHC_80267	11,20	lipase	36,42	RHC 80267	lipase	MESH:C036535	291437(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Effects of RHC_80267 , a diglyceride lipase inhibitor , on prolactin secretion and calcium uptake in GH3 pituitary cells .
3038400	0	RI-78	44,49	renin	27,32	RI-78	renin	MESH:C053171	102122446	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Hypotensive effects of the renin inhibitor -LRB- RI-78 -RRB- and the converting enzyme inhibitor -LRB- teprotide -RRB- in conscious monkeys .
9102307	0	RING-leucine	8,20	rZIP	0,4	RING-leucine	rZIP	null	113894(Tax:10116)	Chemical	Gene	protein|amod|START_ENTITY END_ENTITY|appos|protein	rZIP , a RING-leucine zipper protein that regulates cell fate determination during Dictyostelium development .
11755399	0	RK-682	48,54	VHR	98,101	RK-682	VHR	null	1845	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	Design and synthesis of a dimeric derivative of RK-682 with increased inhibitory activity against VHR , a dual-specificity ERK phosphatase : implications for the molecular mechanism of the inhibition .
8258321	0	RMA-S	64,69	Tap_2	35,40	RMA-S	Tap 2	null	24812(Tax:10116)	Chemical	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	Differential effect of transporter Tap_2 gene introduction into RMA-S cells on viral antigen processing .
24712864	0	RN486	31,36	BTK	87,90	RN486	BTK	null	695	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|appos|END_ENTITY	Structure-Based Drug Design of RN486 , a Potent and Selective Bruton 's _ Tyrosine_Kinase -LRB- BTK -RRB- Inhibitor , for the Treatment of Rheumatoid_Arthritis .
12646284	0	RO-10-5824	0,10	dopamine_D4_receptor	26,46	RO-10-5824	dopamine D4 receptor	MESH:C475158	13491(Tax:10090)	Chemical	Gene	agonist|nsubj|START_ENTITY agonist|amod|END_ENTITY	RO-10-5824 is a selective dopamine_D4_receptor agonist that increases novel object exploration in C57 mice .
19385969	0	RO-3306	36,43	Bax	66,69	RO-3306	Bax	MESH:C512984	12028(Tax:10090)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activation activation|compound|END_ENTITY	Cyclin-dependent_kinase_1 inhibitor RO-3306 enhances p53-mediated Bax activation and mitochondrial apoptosis in AML .
890572	0	RO-4-4602	58,67	catechol_O-methyltransferase	26,54	RO-4-4602	catechol O-methyltransferase	MESH:D001545	1312	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Competitive inhibition of catechol_O-methyltransferase by RO-4-4602 .
12617910	0	RO0094889	104,113	DPD	88,91	RO0094889	DPD	MESH:C477084	1806	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|appos|END_ENTITY	Design and synthesis of the tumor-activated prodrug of dihydropyrimidine_dehydrogenase -LRB- DPD -RRB- inhibitor , RO0094889 for combination therapy with capecitabine .
12617910	0	RO0094889	104,113	dihydropyrimidine_dehydrogenase	55,86	RO0094889	dihydropyrimidine dehydrogenase	MESH:C477084	1806	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Design and synthesis of the tumor-activated prodrug of dihydropyrimidine_dehydrogenase -LRB- DPD -RRB- inhibitor , RO0094889 for combination therapy with capecitabine .
25574601	0	RO3280	81,87	PLK1	97,101	RO3280	PLK1	null	5347	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|compound|END_ENTITY	Molecular Targeting of the Oncoprotein PLK1 in Pediatric_Acute_Myeloid_Leukemia : RO3280 , a Novel PLK1 Inhibitor , Induces Apoptosis in Leukemia Cells .
23564767	0	RO4929097	48,57	PTEN	0,4	RO4929097	PTEN	MESH:C545185	5728	Chemical	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	PTEN regulates sensitivity of melanoma cells to RO4929097 , the y-secretase inhibitor .
26116108	0	RO4987655	47,56	MEK	32,35	RO4987655	MEK	null	5609	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Evaluation of efficacy of a new MEK inhibitor , RO4987655 , in human tumor xenografts by -LSB- -LRB- 18 -RRB- F -RSB- _ FDG-PET imaging combined with proteomic approaches .
20386016	0	RO5068760	89,98	MEK	103,106	RO5068760	MEK	MESH:C547875	5609	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	The safety , tolerability , pharmacokinetics , and pharmacodynamics of single oral doses of RO5068760 , an MEK inhibitor , in healthy volunteers : assessment of target suppression .
24743376	0	RO5263397	57,66	trace_amine-associated_receptor_1	15,48	RO5263397	trace amine-associated receptor 1	null	113914(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|agonist agonist|amod|END_ENTITY	Effects of the trace_amine-associated_receptor_1 agonist RO5263397 on abuse-related effects of cocaine in rats .
24997575	0	RO8994	66,72	MDM2	50,54	RO8994	MDM2	null	4193	Chemical	Gene	Discovery|appos|START_ENTITY Discovery|nmod|inhibitor inhibitor|compound|END_ENTITY	Discovery of potent and selective spiroindolinone MDM2 inhibitor , RO8994 , for cancer therapy .
19712061	0	ROCO	83,87	LRRK2	77,82	ROCO	LRRK2	null	120892	Chemical	Gene	fragment|compound|START_ENTITY fragment|compound|END_ENTITY	Homo - and heterodimerization of ROCO kinases : LRRK2 kinase inhibition by the LRRK2 ROCO fragment .
22517769	0	ROSE-010	44,52	glucagon-like_peptide_1	12,35	ROSE-010	glucagon-like peptide 1	MESH:C574776	2641	Chemical	Gene	analog|appos|START_ENTITY analog|amod|END_ENTITY	Effect of a glucagon-like_peptide_1 analog , ROSE-010 , on GI motor functions in female patients with constipation-predominant irritable_bowel_syndrome .
14534359	0	RO_25-6981	107,117	NR2B	78,82	RO 25-6981	NR2B	MESH:C109643	2904	Chemical	Gene	pocket|compound|START_ENTITY involved|nmod|pocket involved|nsubj|Identification Identification|nmod|residues residues|nmod|domain domain|nmod|subunit subunit|compound|END_ENTITY	Identification of critical residues in the amino terminal domain of the human NR2B subunit involved in the RO_25-6981 binding pocket .
2203486	0	RO_42-5892	68,78	renin	52,57	RO 42-5892	renin	MESH:C065581	5972	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|reduction reduction|nmod|END_ENTITY	Prolonged blood pressure reduction by orally active renin inhibitor RO_42-5892 in essential hypertension .
7694865	0	RP-67580	0,8	NK1_receptor	32,44	RP-67580	NK1 receptor	MESH:C071693	24807(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	RP-67580 , a specific tachykinin NK1_receptor antagonist , relieves chronic_hyperalgesia in diabetic rats .
7684305	11	RP67580	2195,2202	NK1-receptor	2170,2182	RP67580	NK1-receptor	MESH:C071693	24807(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	The foregoing results demonstrate that the non-peptide NK1-receptor antagonist , RP67580 , is a potent inhibitor of plasma extravasation induced in skin by NK1-receptor agonists , by local application of chemical irritants -LRB- capsaicin or xylene -RRB- or by electrical nerve stimulation .
8592631	0	RP67580	0,7	neurokinin1_receptor	11,31	RP67580	neurokinin1 receptor	MESH:C071693	24807(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	RP67580 , a neurokinin1_receptor antagonist , decreased restraint stress-induced defecation in rat .
12115540	0	RPR-115135	0,10	p53	120,123	RPR-115135	p53	MESH:C426728	7157	Chemical	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	RPR-115135 , a farnesyltransferase inhibitor , increases 5-FU - cytotoxicity in ten human colon_cancer cell lines : role of p53 .
12662184	0	RPR100893	0,9	substance-P	13,24	RPR100893	substance-P	MESH:C089835	6863	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	RPR100893 , a substance-P antagonist , is not effective in the treatment of migraine attacks .
7921621	0	RPR_100893	31,41	NK1_receptor	57,69	RPR 100893	NK1 receptor	MESH:C089835	100135626(Tax:10141)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Blockade by oral or parenteral RPR_100893 -LRB- a non-peptide NK1_receptor antagonist -RRB- of neurogenic plasma protein extravasation within guinea-pig dura mater and conjunctiva .
9379497	0	RPR_100893	57,67	NK1_receptor	82,94	RPR 100893	NK1 receptor	MESH:C089835	6869	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|nmod|END_ENTITY	Stimulatory effect of a specific substance_P antagonist -LRB- RPR_100893 -RRB- of the human NK1_receptor on the estradiol-induced LH and FSH surges in the ovariectomized cynomolgus_monkey .
9379497	0	RPR_100893	57,67	substance_P	33,44	RPR 100893	substance P	MESH:C089835	6863	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	Stimulatory effect of a specific substance_P antagonist -LRB- RPR_100893 -RRB- of the human NK1_receptor on the estradiol-induced LH and FSH surges in the ovariectomized cynomolgus_monkey .
9087512	0	RP_55778	11,19	tumor_necrosis_factor_alpha	23,50	RP 55778	tumor necrosis factor alpha	MESH:C052520	7124	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Effects of RP_55778 , a tumor_necrosis_factor_alpha synthesis inhibitor , on antiviral activity of dideoxynucleosides .
1280178	0	RP_58802B	0,9	beta_2-adrenoceptor	25,44	RP 58802B	beta 2-adrenoceptor	MESH:C078396	100722663	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	RP_58802B , a long-acting beta_2-adrenoceptor agonist : assessment of antiasthma activity in the guinea-pig in vivo .
1650834	0	RP_59227	52,60	platelet_activating_factor_receptor	4,39	RP 59227	platelet activating factor receptor	MESH:C065022	100720710	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	The platelet_activating_factor_receptor antagonist , RP_59227 , blocks platelet_activating_factor_receptors mediating liberation of reactive oxygen species in guinea_pig macrophages and human polymorphonuclear leukocytes .
9197945	0	RP_60180	61,69	kappa-opioid_receptor	31,52	RP 60180	kappa-opioid receptor	MESH:C098221	4986	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|agonist agonist|amod|END_ENTITY	Antinociceptive effects of the kappa-opioid_receptor agonist RP_60180 compared with pentazocine in an experimental human pain model .
8957240	0	RP_62203	28,36	dopamine_D4_receptor	76,96	RP 62203	dopamine D4 receptor	MESH:C070475	1815	Chemical	Gene	has|nsubj|START_ENTITY has|dobj|affinity affinity|nmod|END_ENTITY	The naphtosultam derivative RP_62203 -LRB- fananserin -RRB- has high affinity for the dopamine_D4_receptor .
7684305	0	RP_67580	39,47	NK1-receptor	14,26	RP 67580	NK1-receptor	MESH:C071693	24807(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	A non-peptide NK1-receptor antagonist , RP_67580 , inhibits neurogenic_inflammation postsynaptically .
7530576	0	RP_67580	51,59	NK1_receptor	25,37	RP 67580	NK1 receptor	MESH:C071693	24807(Tax:10116)	Chemical	Gene	antagonists|nummod|START_ENTITY END_ENTITY|dep|antagonists	Effect of the tachykinin NK1_receptor antagonists , RP_67580 and SR_140333 , on electrically-evoked substance P release from rat spinal cord .
7691624	0	RP_67580	96,104	NK1_receptor	71,83	RP 67580	NK1 receptor	MESH:C071693	24807(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Inhibition of neurogenic_inflammation in the meninges by a non-peptide NK1_receptor antagonist , RP_67580 .
9639246	0	RP_67580	149,157	NK1_receptor	124,136	RP 67580	NK1 receptor	MESH:C071693	24807(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	The in vitro effect of substance P on the GnRH-induced LH release depends on the steroidal environment and is reverted by a NK1_receptor antagonist -LRB- RP_67580 -RRB- in the cycling female rat .
8937424	0	RP_73163	104,112	ACAT	88,92	RP 73163	ACAT	MESH:C092200	6646	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Hypolipidaemic properties of a potent and bioavailable alkylsulphinyl-diphenylimidazole ACAT inhibitor -LRB- RP_73163 -RRB- in animals fed diets low in cholesterol .
12215965	0	RRR-alpha-tocopherol	11,31	HSP72	59,64	RRR-alpha-tocopherol	HSP72	CHEBI:18145	3303	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of RRR-alpha-tocopherol on leukocyte expression of HSP72 in response to exhaustive treadmill exercise .
12972248	0	RRR-alpha-tocopherylquinone	43,70	Supernatant_protein_factor	0,26	RRR-alpha-tocopherylquinone	Supernatant protein factor	null	23541	Chemical	Gene	complex|nmod|START_ENTITY END_ENTITY|nmod|complex	Supernatant_protein_factor in complex with RRR-alpha-tocopherylquinone : a link between oxidized Vitamin_E and cholesterol biosynthesis .
12460638	0	RS-0466	17,24	Akt	80,83	RS-0466	Akt	MESH:C475699	207	Chemical	Gene	reverses|nsubj|START_ENTITY reverses|nmod|END_ENTITY	A novel compound RS-0466 reverses beta-amyloid-induced cytotoxicity through the Akt signaling pathway in vitro .
14501158	0	RS-1259	36,43	acetylcholinesterase	80,100	RS-1259	acetylcholinesterase	MESH:C487591	83817(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Pharmacological characterization of RS-1259 , an orally active dual inhibitor of acetylcholinesterase and serotonin_transporter , in rodents : possible treatment of Alzheimer 's _ disease .
10455251	0	RS-127445	0,9	5-HT2B	59,65	RS-127445	5-HT2B	MESH:C121466	3357	Chemical	Gene	START_ENTITY|dep|antagonist antagonist|amod|END_ENTITY	RS-127445 : a selective , high affinity , orally bioavailable 5-HT2B receptor antagonist .
8632751	0	RS-17053	0,8	alpha_1A-adrenoceptor	133,154	RS-17053	alpha 1A-adrenoceptor	MESH:C099495	148	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	RS-17053 -LRB- N - -LSB- 2 - -LRB- 2-cyclopropylmethoxyphenoxy -RRB- ethyl -RSB- -5 - chloro-alpha , _ alpha-dimethyl-1H-indole-3-ethanamine_hydrochloride -RRB- , a selective alpha_1A-adrenoceptor antagonist , displays low affinity for functional alpha 1-adrenoceptors in human prostate : implications for adrenoceptor classification .
20522980	0	RS-1748	0,7	CC_chemokine_receptor_4	17,40	RS-1748	CC chemokine receptor 4	MESH:C554823	100379615(Tax:10141)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	RS-1748 , a novel CC_chemokine_receptor_4 antagonist , inhibits ovalbumin-induced airway_inflammation in guinea_pigs .
7646560	0	RS-21607	12,20	lanosterol_14_alpha-demethylase	25,56	RS-21607	lanosterol 14 alpha-demethylase	MESH:C082410	1595	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Azalanstat -LRB- RS-21607 -RRB- , a lanosterol_14_alpha-demethylase inhibitor with cholesterol-lowering activity .
8161528	0	RS-21607	69,77	lanosterol_14_alpha-demethylase	34,65	RS-21607	lanosterol 14 alpha-demethylase	MESH:C082410	1595	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Selective inhibition of mammalian lanosterol_14_alpha-demethylase by RS-21607 in vitro and in vivo .
1686228	0	RS-26306	15,23	luteinizing_hormone-releasing_hormone	34,71	RS-26306	luteinizing hormone-releasing hormone	MESH:C061018	25194(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Disposition of RS-26306 , a potent luteinizing_hormone-releasing_hormone antagonist , in monkeys and rats after single intravenous and subcutaneous administration .
15704197	0	RS-8359	36,43	MAO-A	72,77	RS-8359	MAO-A	MESH:C059590	29253(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Stereoselective pharmacokinetics of RS-8359 , a selective and reversible MAO-A inhibitor , by species-dependent drug-metabolizing enzymes .
16192108	0	RS-8359	50,57	MAO-A	107,112	RS-8359	MAO-A	MESH:C059590	29253(Tax:10116)	Chemical	Gene	enantiomer|nmod|START_ENTITY enantiomer|appos|inhibitor inhibitor|appos|END_ENTITY	Stereospecific oxidation of the -LRB- S -RRB- - enantiomer of RS-8359 , a selective and reversible monoamine_oxidase_A -LRB- MAO-A -RRB- inhibitor , by aldehyde oxidase .
16400710	0	RS-8359	56,63	MAO-A	92,97	RS-8359	MAO-A	MESH:C059590	4128	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Species differences in enantioselective 2-oxidations of RS-8359 , a selective and reversible MAO-A inhibitor , and cinchona_alkaloids by aldehyde oxidase .
16586463	0	RS-8359	56,63	MAO-A	92,97	RS-8359	MAO-A	MESH:C059590	29253(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Rat_strain differences in stereospecific 2-oxidation of RS-8359 , a reversible and selective MAO-A inhibitor , by aldehyde oxidase .
16642492	0	RS-8359	36,43	MAO-A	72,77	RS-8359	MAO-A	MESH:C059590	17161(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Enantioselective 2-hydroxylation of RS-8359 , a selective and reversible MAO-A inhibitor , by cytochrome P450 in mouse and rat liver microsomes .
16823812	0	RS-8359	20,27	MAO-A	56,61	RS-8359	MAO-A	MESH:C059590	29253(Tax:10116)	Chemical	Gene	inversion|nmod|START_ENTITY inversion|dep|inhibitor inhibitor|amod|END_ENTITY	Chiral inversion of RS-8359 : a selective and reversible MAO-A inhibitor via oxido-reduction of keto-alcohol .
10375171	0	RS-8359	36,43	monoamine_oxidase	92,109	RS-8359	monoamine oxidase	MESH:C059590	29253(Tax:10116)	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY pharmacokinetics|appos|inhibitor inhibitor|nmod|END_ENTITY	Stereoselective pharmacokinetics of RS-8359 , a selective and reversible inhibitor of A-type monoamine_oxidase , in rats , mice , dogs , and monkeys .
16574311	0	RS5444	0,6	PPARgamma	16,25	RS5444	PPARgamma	MESH:C510342	25664(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	RS5444 , a novel PPARgamma agonist , regulates aspects of the differentiated phenotype in nontransformed intestinal epithelial cells .
22023668	0	RTI-336	56,63	dopamine_transporter	21,41	RTI-336	dopamine transporter	MESH:C506585	574143(Tax:9544)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|Influence Influence|nmod|END_ENTITY	Influence of chronic dopamine_transporter inhibition by RTI-336 on motor behavior , sleep , and hormone levels in rhesus_monkeys .
19226282	0	RTI-371	73,80	dopamine_transporter	111,131	RTI-371	dopamine transporter	MESH:C541713	6531	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Positive allosteric modulation of the human cannabinoid -LRB- CB -RRB- receptor by RTI-371 , a selective inhibitor of the dopamine_transporter .
7714769	1	RTI-55	111,117	5-HT_transporter	138,154	RTI-55	5-HT transporter	MESH:C069723	25553(Tax:10116)	Chemical	Gene	START_ENTITY|acl|associated associated|nmod|END_ENTITY	V. Demonstration of two binding sites for the cocaine analog -LSB- 125I -RSB- RTI-55 associated with the 5-HT_transporter in rat brain membranes .
10997726	0	RTI-76	0,6	dopamine_transporter	112,132	RTI-76	dopamine transporter	MESH:C101790	6531	Chemical	Gene	START_ENTITY|nmod|tool tool|nmod|function function|compound|END_ENTITY	RTI-76 , an isothiocyanate derivative of a phenyltropane_cocaine analog , as a tool for irreversibly inactivating dopamine_transporter function in vitro .
11282369	0	RTI-76	0,6	dopamine_transporter	37,57	RTI-76	dopamine transporter	MESH:C101790	24898(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	RTI-76 , an irreversible inhibitor of dopamine_transporter binding , increases locomotor activity in the rat at high doses .
14980619	0	RTX	134,137	VR1	142,145	RTX	VR1	null	56664	Chemical	Gene	START_ENTITY|nmod|binding binding|compound|END_ENTITY	Structure-activity relationships of simplified resiniferatoxin analogues with potent VR1 agonism elucidates an active conformation of RTX for VR1 binding .
24066305	0	RU28318	0,7	ACE	59,62	RU28318	ACE	MESH:C041006	24310(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|combination combination|nmod|inhibitor inhibitor|compound|END_ENTITY	RU28318 , an aldosterone antagonist , in combination with an ACE inhibitor and angiotensin receptor blocker attenuates cardiac_dysfunction in diabetes .
22804935	0	RU486	48,53	Nrf2	16,20	RU486	Nrf2	MESH:D015735	4780	Chemical	Gene	induced|nmod|START_ENTITY expression|acl|induced expression|amod|END_ENTITY	-LSB- The effects of Nrf2 gene expression induced by RU486 at different doses on A549 cell damage induced by paraquat -RSB- .
17701593	6	RU486	1381,1386	PIBF	1397,1401	RU486	PIBF	MESH:D015735	10464	Chemical	Gene	decreased|nsubj|START_ENTITY decreased|dobj|END_ENTITY	P increased and RU486 decreased PIBF in U937 , SRIK-B -LRB- T-PLL -RRB- and SRIK-NKL .
15338309	0	RU486	12,17	UCP1	26,30	RU486	UCP1	MESH:D015735	7350	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nummod|END_ENTITY	The steroid RU486 induces UCP1 expression in brown adipocytes .
1751392	0	RU486	23,28	interleukin-2_receptors	61,84	RU486	interleukin-2 receptors	MESH:D015735	3559	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|nmod|END_ENTITY	The antiglucocorticoid RU486 downregulates the expression of interleukin-2_receptors in normal human lymphocytes .
1420166	0	RU486	34,39	progesterone_receptor	69,90	RU486	progesterone receptor	MESH:D015735	5241	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of the steroid antagonist RU486 on dimerization of the human progesterone_receptor .
1586949	0	RU486	17,22	progesterone_receptor	109,130	RU486	progesterone receptor	MESH:D015735	5241	Chemical	Gene	antagonism|compound|START_ENTITY mechanism|nmod|antagonism dependent|nsubj|mechanism dependent|nmod|conformation conformation|nmod|tail tail|nmod|END_ENTITY	The mechanism of RU486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone_receptor .
1932004	0	RU486	40,45	progesterone_receptor	70,91	RU486	progesterone receptor	MESH:D015735	5241	Chemical	Gene	mechanism|nmod|START_ENTITY Differences|nmod|mechanism Differences|nmod|END_ENTITY	Differences in the binding mechanism of RU486 and progesterone to the progesterone_receptor .
19372222	0	RU486	23,28	progesterone_receptor	42,63	RU486	progesterone receptor	MESH:D015735	5241	Chemical	Gene	structure|nmod|START_ENTITY bound|nsubj|structure bound|nmod|END_ENTITY	The X-ray structure of RU486 bound to the progesterone_receptor in a destabilized agonistic conformation .
21945546	0	RU486	11,16	progesterone_receptor	38,59	RU486	progesterone receptor	MESH:D015735	25154(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effects of RU486 in the expression of progesterone_receptor isoforms in the hypothalamus and the preoptic area of the rat during postpartum estrus .
2249658	0	RU486	41,46	progesterone_receptor	77,98	RU486	progesterone receptor	MESH:D015735	5241	Chemical	Gene	activities|nmod|START_ENTITY activities|nmod|functions functions|nmod|END_ENTITY	Agonistic and antagonistic activities of RU486 on the functions of the human progesterone_receptor .
2772964	0	RU486	21,26	progesterone_receptor	114,135	RU486	progesterone receptor	MESH:D015735	100009094(Tax:9986)	Chemical	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	The antiprogesterone RU486 stabilizes the heterooligomeric , non-DNA-binding , 8S-form of the rabbit uterus cytosol progesterone_receptor .
3199817	0	RU486	110,115	progesterone_receptor	24,45	RU486	progesterone receptor	MESH:D015735	5241	Chemical	Gene	progestin|appos|START_ENTITY presence|nmod|progestin Transformation|nmod|presence Transformation|nmod|END_ENTITY	Transformation of human progesterone_receptor in the presence of the progestin -LRB- R5020 -RRB- and the antiprogestin -LRB- RU486 -RRB- .
3972969	0	RU486	0,5	progesterone_receptor	101,122	RU486	progesterone receptor	MESH:D015735	5241	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|growth growth|nmod|cells cells|nmod|END_ENTITY	RU486 , a progestin and glucocorticoid antagonist , inhibits the growth of breast_cancer cells via the progesterone_receptor .
3987685	1	RU486	89,94	progesterone_receptor	102,123	RU486	progesterone receptor	MESH:D015735	100009094(Tax:9986)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of RU486 on the progesterone_receptor and on the expression of the uteroglobin gene .
8163495	0	RU486	0,5	progesterone_receptor	55,76	RU486	progesterone receptor	MESH:D015735	5241	Chemical	Gene	exerts|nsubj|START_ENTITY exerts|nmod|END_ENTITY	RU486 exerts antiestrogenic activities through a novel progesterone_receptor A form-mediated mechanism .
8710941	0	RU486	50,55	progesterone_receptor	98,119	RU486	progesterone receptor	MESH:D015735	5241	Chemical	Gene	analogs|nmod|START_ENTITY induce|nsubj|analogs induce|dobj|conformation conformation|nmod|END_ENTITY	16 alpha-substituted analogs of the antiprogestin RU486 induce a unique conformation in the human progesterone_receptor resulting in mixed agonist activity .
2051768	0	RU_38486	74,82	interleukin-1_alpha	14,33	RU 38486	interleukin-1 alpha	MESH:D015735	24493(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|END_ENTITY	The effect of interleukin-1_alpha and the glucocorticoid receptor blocker RU_38486 on total and myofibrillar protein breakdown in skeletal muscle .
9304405	0	RU_41740	0,8	granulocyte_macrophage_colony-stimulating_factor	48,96	RU 41740	granulocyte macrophage colony-stimulating factor	null	1437	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|nmod|END_ENTITY	RU_41740 -LRB- Biostim -RRB- stimulates the production of granulocyte_macrophage_colony-stimulating_factor and interleukin-8 by human bronchial epithelial cells in vitro .
3874176	0	RU_41740	100,108	interleukin_1	13,26	RU 41740	interleukin 1	null	3552	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Induction Induction|nmod|END_ENTITY	Induction of interleukin_1 secretion by murine macrophages and human monocytes after stimulation by RU_41740 , a bacterial immunomodulator .
1352370	0	RU_42	131,136	beta-2	115,121	RU 42	beta-2	null	10242	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Best mode of expression of acute reversibility of airway_obstruction in patients with asthma : application to a new beta-2 agonist , RU_42 173 .
7926266	0	RU_486	73,79	calbindin-D9k	14,27	RU 486	calbindin-D9k	MESH:D015735	24249(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY Expression|dep|effects Expression|nmod|END_ENTITY	Expression of calbindin-D9k in the early pregnant rat uterus : effects of RU_486 and correlation to estrogen receptor mRNA .
9408050	0	RU_51599	21,29	vasopressin	39,50	RU 51599	vasopressin	MESH:C100946	551	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Kappa opiate agonist RU_51599 inhibits vasopressin gene expression and osmotically-induced vasopressin secretion in vitro .
24248379	0	RVX-208	0,7	BET	25,28	RVX-208	BET	MESH:C550378	92737	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|regulators regulators|compound|END_ENTITY	RVX-208 , an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain .
24391744	0	RVX-208	0,7	BET	46,49	RVX-208	BET	MESH:C550378	92737	Chemical	Gene	antagonist|nsubj|START_ENTITY antagonist|compound|END_ENTITY	RVX-208 , an inducer of ApoA-I in humans , is a BET bromodomain antagonist .
25016363	0	RVX-208	35,42	BET	8,11	RVX-208	BET	MESH:C550378	227325(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	A novel BET bromodomain inhibitor , RVX-208 , shows reduction of atherosclerosis in hyperlipidemic_ApoE_deficient mice .
26385396	0	RVX-208	37,44	BET	14,17	RVX-208	BET	MESH:C550378	92737	Chemical	Gene	Inhibitor|appos|START_ENTITY Inhibitor|compound|END_ENTITY	Effect of the BET Protein Inhibitor , RVX-208 , on Progression of Coronary_Atherosclerosis : Results of the Phase 2b , Randomized , Double-Blind , Multicenter , ASSURE Trial .
11779391	0	RWJ-270201	0,10	neuraminidase	31,44	RWJ-270201	neuraminidase	MESH:C414210	4758	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	RWJ-270201 -LRB- BCX-1812 -RRB- : a novel neuraminidase inhibitor for influenza .
12919021	0	RWJ-270201	53,63	neuraminidase	88,101	RWJ-270201	neuraminidase	MESH:C414210	4758	Chemical	Gene	synthesis|appos|START_ENTITY synthesis|nmod|development development|nmod|inhibitors inhibitors|amod|END_ENTITY	Stereoselective total synthesis of racemic BCX-1812 -LRB- RWJ-270201 -RRB- for the development of neuraminidase inhibitors as anti-influenza agents .
10706936	0	RWJ-50353	29,38	thrombin	59,67	RWJ-50353	thrombin	MESH:C100912	2147	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Antithrombotic properties of RWJ-50353 , a potent and novel thrombin inhibitor .
11876759	0	RWJ-67657	128,137	p38_MAP-kinase	141,155	RWJ-67657	p38 MAP-kinase	MESH:C400277	1432	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Monocyte intracellular cytokine production during human endotoxaemia with or without a second in vitro LPS challenge : effect of RWJ-67657 , a p38_MAP-kinase inhibitor , on LPS-hyporesponsiveness .
11359438	0	RWJ-67657	66,75	p38_mitogen-activated_protein-kinase	79,115	RWJ-67657	p38 mitogen-activated protein-kinase	MESH:C400277	1432	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Suppression of the clinical and cytokine response to endotoxin by RWJ-67657 , a p38_mitogen-activated_protein-kinase inhibitor , in healthy human volunteers .
22860234	0	RWJ67657	40,48	p38_mitogen_activated_protein_kinase	71,107	RWJ67657	p38 mitogen activated protein kinase	MESH:C400277	1432	Chemical	Gene	activity|nmod|START_ENTITY activity|appos|inhibitor inhibitor|nmod|END_ENTITY	Pharmacology and anti-tumor activity of RWJ67657 , a novel inhibitor of p38_mitogen_activated_protein_kinase .
9262379	0	RWJ_63556	107,116	cyclooxygenase-2	54,70	RWJ 63556	cyclooxygenase-2	MESH:C107693	442942(Tax:9615)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Evaluation of the antiinflammatory activity of a dual cyclooxygenase-2 selective/5-lipoxygenase inhibitor , RWJ_63556 , in a canine model of inflammation .
15225374	0	RWJ_67657	126,135	IL-8	60,64	RWJ 67657	IL-8	MESH:C400277	3576	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|expression expression|amod|END_ENTITY	Strong inhibition of TNF-alpha production and inhibition of IL-8 and COX-2 mRNA expression in monocyte-derived macrophages by RWJ_67657 , a p38_mitogen-activated_protein_kinase -LRB- MAPK -RRB- inhibitor .
10525088	0	RWJ_67657	0,9	p38	48,51	RWJ 67657	p38	MESH:C400277	1432	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|kinase kinase|amod|END_ENTITY	RWJ_67657 , a potent , orally active inhibitor of p38 mitogen-activated protein kinase .
15225374	0	RWJ_67657	126,135	p38_mitogen-activated_protein_kinase	139,175	RWJ 67657	p38 mitogen-activated protein kinase	MESH:C400277	1432	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Strong inhibition of TNF-alpha production and inhibition of IL-8 and COX-2 mRNA expression in monocyte-derived macrophages by RWJ_67657 , a p38_mitogen-activated_protein_kinase -LRB- MAPK -RRB- inhibitor .
15479895	0	RWJ_67657	11,20	p38_mitogen_activated_protein_kinase	24,60	RWJ 67657	p38 mitogen activated protein kinase	MESH:C400277	1432	Chemical	Gene	Effects|nmod|START_ENTITY inhibitor|nsubj|Effects inhibitor|nsubj|END_ENTITY	Effects of RWJ_67657 , a p38_mitogen_activated_protein_kinase -LRB- MAPK -RRB- inhibitor , on the production of inflammatory mediators by rheumatoid synovial fibroblasts .
10200262	0	RXP_407	0,7	angiotensin_I_converting_enzyme	56,87	RXP 407	angiotensin I converting enzyme	MESH:C118733	1636	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	RXP_407 , a phosphinic peptide , is a potent inhibitor of angiotensin_I_converting_enzyme able to differentiate between its two active sites .
25455158	0	RY10-4	17,23	P-glycoprotein	38,52	RY10-4	P-glycoprotein	MESH:C574037	5243	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	A novel compound RY10-4 downregulates P-glycoprotein expression and reverses multidrug-resistant phenotype in human breast_cancer MCF-7 / ADR cells .
2696850	0	R_76713	24,31	Aromatase	0,9	R 76713	Aromatase	MESH:C060523	25147(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Aromatase inhibition by R_76713 : experimental and clinical pharmacology .
16359345	0	Rabeprazole	0,11	CYP2C19	42,49	Rabeprazole	CYP2C19	MESH:C063129	1557	Chemical	Gene	experience|amod|START_ENTITY experience|dep|focus focus|nmod|polymorphism polymorphism|compound|END_ENTITY	Rabeprazole experience in Korea ; focus on CYP2C19 polymorphism .
20633187	0	Rabeprazole	0,11	CYP2C19	39,46	Rabeprazole	CYP2C19	MESH:C063129	1557	Chemical	Gene	overcome|nsubj|START_ENTITY overcome|dobj|impact impact|nmod|polymorphism polymorphism|compound|END_ENTITY	Rabeprazole can overcome the impact of CYP2C19 polymorphism on quadruple therapy .
22882464	0	Rabeprazole	0,11	CYP2C19	134,141	Rabeprazole	CYP2C19	MESH:C063129	1557	Chemical	Gene	decreases|advmod|START_ENTITY decreases|advcl|overcoming overcoming|dobj|genotype genotype|compound|END_ENTITY	Rabeprazole 10 mg q.d.s. decreases 24-h intragastric acidity significantly more than rabeprazole 20 mg b.d. or 40 mg o.m. , overcoming CYP2C19 genotype .
11007781	0	Radicicol	0,9	ATP_citrate_lyase	39,56	Radicicol	ATP citrate lyase	MESH:C035359	47	Chemical	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Radicicol binds and inhibits mammalian ATP_citrate_lyase .
15360086	0	Radicicol	0,9	Hsp90	93,98	Radicicol	Hsp90	MESH:C035359	3320	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|parataxis|chaperone chaperone|nsubj|END_ENTITY	Radicicol potentiates heat-induced cell killing in a human oesophageal_cancer cell line : the Hsp90 chaperone complex as a new molecular target for enhancement of thermosensitivity .
23138048	0	Radicicol	0,9	Hsp90	14,19	Radicicol	Hsp90	MESH:C035359	104434(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Radicicol , an Hsp90 inhibitor , inhibits intestinal_inflammation and leakage in abdominal_sepsis .
8930398	0	Radicicol	0,9	Sam68	73,78	Radicicol	Sam68	MESH:C035359	20218(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Radicicol inhibits tyrosine phosphorylation of the mitotic Src substrate Sam68 and retards subsequent exit from mitosis of Src-transformed cells .
23727383	0	Radicicol	0,9	heat_shock_protein_90	13,34	Radicicol	heat shock protein 90	MESH:C035359	3320	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Radicicol , a heat_shock_protein_90 inhibitor , inhibits differentiation and adipogenesis in 3T3-L1 preadipocytes .
10900231	0	Radicicol	0,9	inducible_nitric-oxide_synthase	35,66	Radicicol	inducible nitric-oxide synthase	MESH:C035359	4843	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|nmod|END_ENTITY	Radicicol suppresses expression of inducible_nitric-oxide_synthase by blocking p38 kinase and nuclear factor-kappaB/Rel in lipopolysaccharide-stimulated macrophages .
25360988	0	Radioiodinated_Acyloxymethyl_Ketones	28,64	Cathepsin_B	94,105	Radioiodinated Acyloxymethyl Ketones	Cathepsin B	null	13030(Tax:10090)	Chemical	Gene	Synthesis|nmod|START_ENTITY Synthesis|nmod|END_ENTITY	Synthesis and Evaluation of Radioiodinated_Acyloxymethyl_Ketones as Activity-Based Probes for Cathepsin_B .
7581287	0	Radon	0,5	spa	24,27	Radon	spa	MESH:D011886	729238	Chemical	Gene	concentrations|compound|START_ENTITY concentrations|nmod|water water|compound|END_ENTITY	Radon concentrations in spa water taken from hot and cold springs in Taiwan .
21317202	0	Raf265	24,30	Bcl-2	41,46	Raf265	Bcl-2	MESH:C559019	596	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|levels levels|compound|END_ENTITY	The novel Raf inhibitor Raf265 decreases Bcl-2 levels and confers TRAIL-sensitivity to neuroendocrine_tumour cells .
26581242	0	Ralimetinib	63,74	p38	43,46	Ralimetinib	p38	null	1432	Chemical	Gene	Inhibitor|appos|START_ENTITY Inhibitor|compound|END_ENTITY	A First-in-Human Phase I Study of the Oral p38 MAPK Inhibitor , Ralimetinib -LRB- LY2228820_Dimesylate -RRB- , in Patients with Advanced_Cancer .
21335463	0	Raloxifene	0,10	Gas6	22,26	Raloxifene	Gas6	MESH:D020849	58935(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|END_ENTITY	Raloxifene attenuates Gas6 and apoptosis in experimental aortic_valve_disease in renal_failure .
12656665	0	Raloxifene	0,10	IGF-I	18,23	Raloxifene	IGF-I	MESH:D020849	3479	Chemical	Gene	lowers|nsubj|START_ENTITY lowers|dobj|levels levels|amod|END_ENTITY	Raloxifene lowers IGF-I levels in acromegalic women .
15080777	0	Raloxifene	0,10	IGF-I	27,32	Raloxifene	IGF-I	MESH:D020849	3479	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|END_ENTITY	Raloxifene decreases serum IGF-I in male patients with active acromegaly .
21920358	0	Raloxifene	0,10	IL-1b	53,58	Raloxifene	IL-1b	MESH:D020849	3553	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|END_ENTITY	Raloxifene protects cultured human chondrocytes from IL-1b induced damage : a biochemical and morphological study .
21937736	0	Raloxifene	0,10	UGT1A1	124,130	Raloxifene	UGT1A1	MESH:D020849	54658	Chemical	Gene	glucuronidation|amod|START_ENTITY genotyped|nsubj|glucuronidation genotyped|nmod|END_ENTITY	Raloxifene glucuronidation in human intestine , kidney , and liver microsomes and in human liver microsomes genotyped for the UGT1A1 * 28 polymorphism .
20083158	0	Raloxifene	0,10	estrogen_receptor	50,67	Raloxifene	estrogen receptor	MESH:D020849	2099	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|translocation translocation|nmod|END_ENTITY	Raloxifene induces nucleolar translocation of the estrogen_receptor .
15579764	0	Raloxifene	0,10	interleukin-6_and_tumor_necrosis_factor-alpha	21,66	Raloxifene	interleukin-6 and tumor necrosis factor-alpha	MESH:D020849	3569;7124	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|synthesis synthesis|amod|END_ENTITY	Raloxifene modulates interleukin-6_and_tumor_necrosis_factor-alpha synthesis in vivo : results from a pilot clinical study .
12970288	0	Raloxifene	0,10	osteoprotegerin	35,50	Raloxifene	osteoprotegerin	MESH:D020849	4982	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Raloxifene concurrently stimulates osteoprotegerin and inhibits interleukin-6 production by human trabecular osteoblasts .
16787719	0	Raloxifene	0,10	osteoprotegerin	40,55	Raloxifene	osteoprotegerin	MESH:D020849	4982	Chemical	Gene	therapy|amod|START_ENTITY interacts|nsubj|therapy interacts|nmod|END_ENTITY	Raloxifene therapy interacts with serum osteoprotegerin in postmenopausal women .
21078936	0	Raltegravir	0,11	SLC22A6	31,38	Raltegravir	SLC22A6	MESH:C507898	9356	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Raltegravir is a substrate for SLC22A6 : a putative mechanism for the interaction between raltegravir and tenofovir .
19767422	0	RamB	38,42	Rv0465c	44,51	RamB	Rv0465c	null	886320(Tax:83332)	Chemical	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of the transcriptional regulator RamB -LRB- Rv0465c -RRB- in the control of the glyoxylate cycle in Mycobacterium_tuberculosis .
25494680	0	Ramalin	0,7	VCAM-1	17,23	Ramalin	VCAM-1	null	7412	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Ramalin inhibits VCAM-1 expression and adhesion of monocyte to vascular smooth muscle cells through MAPK and PADI4-dependent NF-kB and AP-1 pathways .
15215792	0	Ramipril	219,227	ACE	293,296	Ramipril	ACE	MESH:D017257	1636	Chemical	Gene	Study|compound|START_ENTITY Study|nmod|Subjects Subjects|compound|END_ENTITY	Rationale , design , and baseline characteristics of 2 large , simple , randomized trials evaluating telmisartan , ramipril , and their combination in high-risk patients : the Ongoing Telmisartan_Alone and in Combination with Ramipril Global Endpoint Trial/Telmisartan Randomized Assessment Study in ACE Intolerant Subjects with Cardiovascular_Disease -LRB- ONTARGET/TRANSCEND -RRB- trials .
1532570	0	Ramipril	0,8	ACE	30,33	Ramipril	ACE	MESH:D017257	1636	Chemical	Gene	START_ENTITY|dep|review review|nmod|inhibitor inhibitor|compound|END_ENTITY	Ramipril : a review of the new ACE inhibitor .
12195686	0	Ramipril	0,8	PAI-1	64,69	Ramipril	PAI-1	MESH:D017257	5054	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|increase increase|nmod|END_ENTITY	Ramipril prior to thrombolysis attenuates the early increase of PAI-1 in patients with acute myocardial_infarction .
2831105	0	Ramipril	108,116	angiotensin-converting_enzyme	30,59	Ramipril	angiotensin-converting enzyme	MESH:D017257	1636	Chemical	Gene	brush|nmod|START_ENTITY brush|dobj|activity activity|amod|END_ENTITY	Human intestinal brush border angiotensin-converting_enzyme activity and its inhibition by antihypertensive Ramipril .
2905962	0	Ramipril	0,8	angiotensin_converting_enzyme	93,122	Ramipril	angiotensin converting enzyme	MESH:D017257	100009274(Tax:9986)	Chemical	Gene	inhibition|amod|START_ENTITY END_ENTITY|nsubj|inhibition	Ramipril inhibition of rabbit -LRB- Oryctolagus_cuniculus -RRB- small intestinal brush border membrane angiotensin_converting_enzyme .
25143788	0	Ramipril	0,8	matrix_metalloproteinase-2	35,61	Ramipril	matrix metalloproteinase-2	MESH:D017257	81686(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	Ramipril inhibits AGE-RAGE-induced matrix_metalloproteinase-2 activation in experimental diabetic_nephropathy .
1658233	0	Ranakinin	0,9	NK1	19,22	Ranakinin	NK1	MESH:C071642	6869	Chemical	Gene	START_ENTITY|dep|agonist agonist|compound|END_ENTITY	Ranakinin : a novel NK1 tachykinin receptor agonist isolated with neurokinin_B from the brain of the frog Rana ridibunda .
20026516	0	Ranitidine	0,10	alcohol_dehydrogenase	17,38	Ranitidine	alcohol dehydrogenase	MESH:D011899	78959(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|amod|END_ENTITY	Ranitidine as an alcohol_dehydrogenase inhibitor in acute methanol toxicity in rats .
20298924	0	Ranolazine	188,198	B-type_natriuretic_peptide	0,26	Ranolazine	B-type natriuretic peptide	MESH:C055512	4879	Chemical	Gene	Efficiency|nmod|START_ENTITY 36|dep|Efficiency trial|amod|36 observations|nmod|trial effect|dep|observations effect|amod|END_ENTITY	B-type_natriuretic_peptide and the effect of ranolazine in patients with non-ST-segment elevation acute_coronary_syndromes : observations from the MERLIN-TIMI 36 -LRB- Metabolic Efficiency With Ranolazine for Less Ischemia in Non-ST Elevation Acute Coronary-Thrombolysis In Myocardial_Infarction 36 -RRB- trial .
22245792	0	Ranolazine	0,10	ryanodine_receptors	30,49	Ranolazine	ryanodine receptors	MESH:C055512	100009536(Tax:9986)	Chemical	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	Ranolazine stabilizes cardiac ryanodine_receptors : a novel mechanism for the suppression of early afterdepolarization and torsades_de_pointes in long_QT_type_2 .
19684592	0	Rapamycin	0,9	4E-BP	24,29	Rapamycin	4E-BP	MESH:D020123	33569(Tax:7227)	Chemical	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Rapamycin activation of 4E-BP prevents parkinsonian_dopaminergic_neuron_loss .
8599949	0	Rapamycin	0,9	4E-BP1	40,46	Rapamycin	4E-BP1	MESH:D020123	1978	Chemical	Gene	blocks|nsubj|START_ENTITY blocks|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation .
23476113	0	Rapamycin	0,9	ALDH	19,23	Rapamycin	ALDH	MESH:D020123	11670(Tax:10090)	Chemical	Gene	Activity|compound|START_ENTITY Activity|compound|END_ENTITY	Rapamycin Inhibits ALDH Activity , Resistance to Oxidative Stress , and Metastatic Potential in Murine Osteosarcoma Cells .
17001314	0	Rapamycin	0,9	Akt	41,44	Rapamycin	Akt	MESH:D020123	207	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|nmod|END_ENTITY	Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism .
22071989	0	Rapamycin	0,9	C/EBPb	80,86	Rapamycin	C/EBPb	MESH:D020123	12608(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Rapamycin inhibits osteoclast formation in giant_cell_tumor of bone through the C/EBPb - MafB axis .
12915736	0	Rapamycin	0,9	CCR5	36,40	Rapamycin	CCR5	MESH:D020123	1234	Chemical	Gene	causes|nsubj|START_ENTITY causes|dobj|down-regulation down-regulation|nmod|END_ENTITY	Rapamycin causes down-regulation of CCR5 and accumulation of anti-HIV beta-chemokines : an approach to suppress R5 strains of HIV-1 .
17428387	0	Rapamycin	11,20	CD4	24,27	Rapamycin	CD4	MESH:D020123	12504(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|CD25 CD25|compound|END_ENTITY	-LSB- Effect of Rapamycin on CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells in allo-transplantation tolerance model -RSB- .
26954224	0	Rapamycin	0,9	ELOVL_1	33,40	Rapamycin	ELOVL 1	MESH:D020123	540348(Tax:9913)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Rapamycin inhibits expression of ELOVL_1 and synthesis of docosahexaenoic_acid in bovine mammary epithelial cells .
23403511	0	Rapamycin	0,9	ERK	53,56	Rapamycin	ERK	MESH:D020123	5594	Chemical	Gene	increases|nsubj|START_ENTITY increases|nmod|END_ENTITY	Rapamycin increases pCREB , Bcl-2 , and VEGF-A through ERK under normoxia .
22266730	0	Rapamycin	0,9	GLT-1	52,57	Rapamycin	GLT-1	MESH:D020123	29482(Tax:10116)	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|dobj|expression expression|compound|END_ENTITY	Rapamycin prevents the mutant huntingtin-suppressed GLT-1 expression in cultured astrocytes .
18418733	0	Rapamycin	0,9	Hsp90	33,38	Rapamycin	Hsp90	MESH:D020123	38389(Tax:7227)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Rapamycin conditionally inhibits Hsp90 but not Hsp70 mRNA translation in Drosophila : implications for the mechanisms of Hsp mRNA translation .
20485667	0	Rapamycin	0,9	IGF-1	19,24	Rapamycin	IGF-1	MESH:D020123	3479	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Rapamycin inhibits IGF-1 stimulated cell motility through PP2A pathway .
12531798	0	Rapamycin	0,9	IL-4	19,23	Rapamycin	IL-4	MESH:D020123	16189(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Rapamycin inhibits IL-4 -- induced dendritic cell maturation in vitro and dendritic cell mobilization and function in vivo .
18652845	0	Rapamycin	0,9	ILT4	61,65	Rapamycin	ILT4	MESH:D020123	10288	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	Rapamycin downregulates the inhibitory receptors ILT2 , ILT3 , ILT4 on human dendritic cells and yet induces T cell hyporesponsiveness independent of FoxP3 induction .
26400569	0	Rapamycin	73,82	Insulin	23,30	Rapamycin	Insulin	MESH:D020123	3630	Chemical	Gene	Independently|compound|START_ENTITY Contributes|nmod|Independently Contributes|nmod|Secretion Secretion|compound|END_ENTITY	Nephrin Contributes to Insulin Secretion and Affects Mammalian Target of Rapamycin Signaling Independently of Insulin_Receptor .
18192922	0	Rapamycin	0,9	PAI-1	19,24	Rapamycin	PAI-1	MESH:D020123	5054	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Rapamycin inhibits PAI-1 expression and reduces interstitial_fibrosis and glomerulosclerosis in chronic_allograft_nephropathy .
20937815	0	Rapamycin	0,9	RhoA	80,84	Rapamycin	RhoA	MESH:D020123	387	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|suppressing suppressing|dobj|expression expression|amod|END_ENTITY	Rapamycin inhibits cytoskeleton reorganization and cell motility by suppressing RhoA expression and activity .
22376175	0	Rapamycin	0,9	S6K1	83,87	Rapamycin	S6K1	MESH:D020123	6198	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|kinase kinase|appos|END_ENTITY	Rapamycin inhibition of baculovirus recombinant -LRB- BVr -RRB- ribosomal protein S6 kinase -LRB- S6K1 -RRB- is mediated by an event other than phosphorylation .
18602894	0	Rapamycin	0,9	SREBP-2	66,73	Rapamycin	SREBP-2	MESH:D020123	6721	Chemical	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|nmod|END_ENTITY	Rapamycin down-regulates LDL-receptor expression independently of SREBP-2 .
19126383	0	Rapamycin	11,20	TLR5	60,64	Rapamycin	TLR5	MESH:D020123	53791(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of Rapamycin and Cyclosporin_A on the expression of TLR5 and Foxp3 in allorejection -RSB- .
26540102	0	Rapamycin	41,50	TOR	20,23	Rapamycin	TOR	MESH:D020123	6097	Chemical	Gene	Target|nmod|START_ENTITY END_ENTITY|nmod|Target	On the Discovery of TOR As the Target of Rapamycin .
26158631	0	Rapamycin	20,29	TORC1	0,5	Rapamycin	TORC1	MESH:D020123	47396(Tax:7227)	Chemical	Gene	Defences|compound|START_ENTITY Inhibition|nmod|Defences Inhibition|compound|END_ENTITY	TORC1 Inhibition by Rapamycin Promotes Antioxidant Defences in a Drosophila Model of Friedreich 's _ Ataxia .
15671443	0	Rapamycin	0,9	VEGF	81,85	Rapamycin	VEGF	MESH:D020123	7422	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|presence presence|nmod|END_ENTITY	Rapamycin induces tumor-specific thrombosis via tissue factor in the presence of VEGF .
18703055	0	Rapamycin	0,9	VEGF	18,22	Rapamycin	VEGF	MESH:D020123	7422	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|amod|END_ENTITY	Rapamycin reduces VEGF expression in retinal_pigment_epithelium -LRB- RPE -RRB- and inhibits RPE-induced sprouting angiogenesis in vitro .
19554030	0	Rapamycin	34,43	VEGF	55,59	Rapamycin	VEGF	MESH:D020123	7422	Chemical	Gene	target|nmod|START_ENTITY Targeting|dobj|target Targeting|advcl|inhibit inhibit|dobj|END_ENTITY	Targeting the mammalian target of Rapamycin to inhibit VEGF and cytokines for the treatment of primary effusion_lymphoma .
22900063	0	Rapamycin	0,9	VEGF	107,111	Rapamycin	VEGF	MESH:D020123	7422	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|reducing reducing|dobj|expression expression|nmod|END_ENTITY	Rapamycin inhibits proliferation of hemangioma endothelial cells by reducing HIF-1-dependent expression of VEGF .
20237065	0	Rapamycin	0,9	X-box-binding_protein-1	41,64	Rapamycin	X-box-binding protein-1	MESH:D020123	289754(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Rapamycin inhibits postprandial-mediated X-box-binding_protein-1 splicing in rat liver .
20620542	0	Rapamycin	0,9	activator_protein-1	19,38	Rapamycin	activator protein-1	MESH:D020123	3726	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Rapamycin inhibits activator_protein-1 but not nuclear factor-kappaB activity of mature bone marrow-derived dendritic cells .
14639603	0	Rapamycin	0,9	cdk4	19,23	Rapamycin	cdk4	MESH:D020123	12567(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	Rapamycin inhibits cdk4 activation , p_21 -LRB- WAF1/CIP1 -RRB- expression and G1-phase progression in transformed mouse fibroblasts .
21114628	0	Rapamycin	0,9	granulocyte-colony_stimulating_factor	51,88	Rapamycin	granulocyte-colony stimulating factor	MESH:D020123	1440	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|induction induction|nmod|expression expression|amod|END_ENTITY	Rapamycin inhibits lipopolysaccharide induction of granulocyte-colony_stimulating_factor and inducible nitric_oxide synthase expression in macrophages by reducing the levels of octamer-binding_factor-2 .
12939469	0	Rapamycin	0,9	hTERT	57,62	Rapamycin	hTERT	MESH:D020123	7015	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|decreasing decreasing|dobj|level level|amod|END_ENTITY	Rapamycin inhibits telomerase activity by decreasing the hTERT mRNA level in endometrial_cancer cells .
16249016	0	Rapamycin	0,9	hTERT	19,24	Rapamycin	hTERT	MESH:D020123	7015	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Rapamycin inhibits hTERT telomerase mRNA expression , independent of cell cycle arrest .
12591764	0	Rapamycin	0,9	heme_oxygenase-1	18,34	Rapamycin	heme oxygenase-1	MESH:D020123	3162	Chemical	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Rapamycin induces heme_oxygenase-1 in human pulmonary vascular cells : implications in the antiproliferative response to rapamycin .
22316670	0	Rapamycin	0,9	heme_oxygenase-1	18,34	Rapamycin	heme oxygenase-1	MESH:D020123	24451(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Rapamycin induces heme_oxygenase-1 in liver but inhibits bile flow recovery after ischemia .
19483303	0	Rapamycin	0,9	inducible_nitric_oxide_synthase	25,56	Rapamycin	inducible nitric oxide synthase	MESH:D020123	4843	Chemical	Gene	down-regulates|compound|START_ENTITY END_ENTITY|nsubj|down-regulates	Rapamycin down-regulates inducible_nitric_oxide_synthase by inducing proteasomal degradation .
1614535	0	Rapamycin	0,9	interleukin-2	31,44	Rapamycin	interleukin-2	MESH:D020123	3558	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|compound|END_ENTITY	Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase .
10029080	0	Rapamycin	0,9	mTOR	49,53	Rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	causes|nsubj|START_ENTITY causes|dobj|inhibition inhibition|nmod|END_ENTITY	Rapamycin causes poorly reversible inhibition of mTOR and induces p53-independent apoptosis in human rhabdomyosarcoma cells .
15782132	0	Rapamycin	0,9	mTOR	148,152	Rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|increasing increasing|nmod|mechanisms mechanisms|nmod|activity activity|compound|END_ENTITY	Rapamycin induces apoptosis of JN-DSRCT-1 cells by increasing the Bax : Bcl-xL ratio through concurrent mechanisms dependent and independent of its mTOR inhibitory activity .
16713440	0	Rapamycin	0,9	mTOR	14,18	Rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Rapamycin , an mTOR inhibitor , disrupts triglyceride metabolism in guinea_pigs .
18492954	3	Rapamycin	533,542	mTOR	560,564	Rapamycin	Rheb	MESH:D020123	6009	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Rapamycin , an inhibitor of mTOR , enhanced IL-12 production in LPS-stimulated DCs , whereas the activation of mTOR by lentivirus-mediated transduction of a constitutively active form of Rheb suppressed the production of IL-12 .
18685609	0	Rapamycin	0,9	mTOR	99,103	Rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	reverses|nsubj|START_ENTITY reverses|nmod|END_ENTITY	Rapamycin reverses NPM-ALK-induced glucocorticoid resistance in lymphoid_tumor cells by inhibiting mTOR signaling pathway , enhancing G1 cell cycle arrest and apoptosis .
19414357	0	Rapamycin	0,9	mTOR	21,25	Rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	effects|nsubj|START_ENTITY effects|nmod|END_ENTITY	Rapamycin effects on mTOR signaling in benign , premalignant and malignant human breast epithelial cells .
19584709	0	Rapamycin	0,9	mTOR	15,19	Rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Rapamycin , the mTOR kinase inhibitor , sensitizes acute_myeloid_leukemia cells , HL-60 cells , to the cytotoxic effect of arabinozide_cytarabine .
19642865	0	Rapamycin	0,9	mTOR	98,102	Rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|advcl|blocking blocking|dobj|END_ENTITY	Rapamycin promotes the osteoblastic differentiation of human embryonic stem cells by blocking the mTOR pathway and stimulating the BMP/Smad pathway .
19666112	0	Rapamycin	0,9	mTOR	91,95	Rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|TGFbeta1/Smad TGFbeta1/Smad|acl|signaling signaling|advmod|upstream upstream|nmod|END_ENTITY	Rapamycin induces the TGFbeta1/Smad signaling cascade in renal mesangial cells upstream of mTOR .
21968016	0	Rapamycin	0,9	mTOR	20,24	Rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	activation|nummod|START_ENTITY activation|compound|END_ENTITY	Rapamycin sensitive mTOR activation mediates nerve growth factor -LRB- NGF -RRB- induced cell migration and pro-survival effects against hydrogen_peroxide in retinal_pigment_epithelial cells .
21993902	0	Rapamycin	0,9	mTOR	62,66	Rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	provides|nsubj|START_ENTITY provides|nmod|inhibition inhibition|nmod|END_ENTITY	Rapamycin provides a therapeutic option through inhibition of mTOR signaling in chronic_myelogenous_leukemia .
22037041	0	Rapamycin	0,9	mTOR	48,52	Rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	passes|nsubj|START_ENTITY passes|dobj|torch torch|dep|generation generation|nmod|inhibitors inhibitors|compound|END_ENTITY	Rapamycin passes the torch : a new generation of mTOR inhibitors .
22470459	0	Rapamycin	0,9	mTOR	70,74	Rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	ameliorates|compound|START_ENTITY kidney_fibrosis|nsubj|ameliorates kidney_fibrosis|advcl|inhibiting inhibiting|dobj|activation activation|nmod|END_ENTITY	Rapamycin ameliorates kidney_fibrosis by inhibiting the activation of mTOR signaling in interstitial macrophages and myofibroblasts .
22884327	0	Rapamycin	0,9	mTOR	70,74	Rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	ameliorates|nsubj|START_ENTITY ameliorates|dobj|obesity obesity|acl|associated associated|nmod|END_ENTITY	Rapamycin ameliorates age-dependent obesity associated with increased mTOR signaling in hypothalamic POMC neurons .
23611130	0	Rapamycin	0,9	mTOR	136,140	Rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	sensitizes|compound|START_ENTITY glucocorticoid|nsubj|sensitizes glucocorticoid|advcl|dexamethasone dexamethasone|nmod|suppression suppression|compound|END_ENTITY	Rapamycin sensitizes glucocorticoid resistant acute_lymphoblastic_leukemia CEM-C1 cells to dexamethasone induced apoptosis through both mTOR suppression and up-regulation and activation of glucocorticoid_receptor .
23665330	0	Rapamycin	0,9	mTOR	20,24	Rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	START_ENTITY|dep|targeting targeting|dobj|END_ENTITY	Rapamycin targeting mTOR and hedgehog signaling pathways blocks human rhabdomyosarcoma growth in xenograft murine model .
24255881	0	Rapamycin	38,47	mTOR	0,4	Rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	START_ENTITY|dep|signaling signaling|advmod|END_ENTITY	mTOR signaling in liver regeneration : Rapamycin combined with growth factor treatment .
24587596	0	Rapamycin	0,9	mTOR	75,79	Rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|apoptosis apoptosis|acl|induced induced|nmod|shear_stress shear_stress|nmod|END_ENTITY	Rapamycin attenuates endothelial apoptosis induced by low shear_stress via mTOR and sestrin1 related redox regulation .
24682932	0	Rapamycin	0,9	mTOR	140,144	Rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	combined|nsubj|START_ENTITY combined|advcl|downregulating downregulating|dobj|pathway pathway|compound|END_ENTITY	Rapamycin combined with celecoxib enhanced antitumor effects of mono treatment on chronic myelogenous_leukemia cells through downregulating mTOR pathway .
25256739	0	Rapamycin	31,40	mTOR	12,16	Rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	Signaling|nmod|START_ENTITY Signaling|compound|END_ENTITY	Blockade of mTOR Signaling via Rapamycin Combined with Immunotherapy Augments Antiglioma Cytotoxic and Memory T-Cell Functions .
25257976	0	Rapamycin	30,39	mTOR	15,19	Rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|Effects Effects|nmod|END_ENTITY	Effects of the mTOR inhibitor Rapamycin on Monocyte-Secreted Chemokines .
25591831	0	Rapamycin	22,31	mTOR	33,37	Rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	Target|nmod|START_ENTITY Target|appos|END_ENTITY	Mechanistic Target of Rapamycin -LRB- mTOR -RRB- in Tuberous_Sclerosis_Complex-Associated_Epilepsy .
25836987	0	Rapamycin	0,9	mTOR	24,28	Rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	Inhibition|compound|START_ENTITY Inhibition|nmod|Levels Levels|compound|END_ENTITY	Rapamycin Inhibition of mTOR Reduces Levels of the Na + / H + _ Exchanger_3 in Intestines of Mice and Humans , Leading to Diarrhea .
25918725	0	Rapamycin	22,31	mTOR	14,18	Rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	Results|amod|START_ENTITY END_ENTITY|nmod|Results	Inhibition of mTOR by Rapamycin Results in Auditory Hair Cell Damage and Decreased Spiral Ganglion Neuron Outgrowth and Neurite Formation In Vitro .
25918725	0	Rapamycin	22,31	mTOR	14,18	Rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	Results|amod|START_ENTITY END_ENTITY|nmod|Results	Inhibition of mTOR by Rapamycin Results in Auditory Hair Cell Damage and Decreased Spiral Ganglion Neuron Outgrowth and Neurite Formation In Vitro .
26191215	0	Rapamycin	0,9	mTOR	13,17	Rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Rapamycin , a mTOR inhibitor , induced growth inhibition in retinoblastoma Y79 cell via down-regulation of Bmi-1 .
26379864	0	Rapamycin	0,9	mTOR	14,18	Rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Rapamycin , an mTOR inhibitor , induced apoptosis via independent mitochondrial and death receptor pathway in retinoblastoma Y79 cell .
26681922	0	Rapamycin	30,39	mTOR	14,18	Rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	Brain|compound|START_ENTITY Pathway|nmod|Brain Pathway|compound|END_ENTITY	Inhibition of mTOR Pathway by Rapamycin Reduces Brain Damage in Rats Subjected to Transient Forebrain_Ischemia .
27048303	0	Rapamycin	57,66	mTOR	51,55	Rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	Inhibition|dep|START_ENTITY Inhibition|nmod|Target Target|nmod|Rapamycin Rapamycin|appos|END_ENTITY	Inhibition of the Mechanistic Target of Rapamycin -LRB- mTOR -RRB- - Rapamycin and Beyond .
27048648	0	Rapamycin	0,9	mTOR	185,189	Rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	reverses|nsubj|START_ENTITY reverses|nmod|END_ENTITY	Rapamycin reverses the senescent phenotype and improves immunoregulation of mesenchymal stem cells from MRL/lpr mice and systemic_lupus_erythematosus patients through inhibition of the mTOR signaling pathway .
19395872	0	Rapamycin	0,9	mTORC1	19,25	Rapamycin	mTORC1	MESH:D020123	382056(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Rapamycin inhibits mTORC1 , but not completely .
20512842	0	Rapamycin	0,9	mTORC1	56,62	Rapamycin	mTORC1	MESH:D020123	382056(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|signaling signaling|dep|phosphorylation phosphorylation|nmod|END_ENTITY	Rapamycin regulates Akt and ERK phosphorylation through mTORC1 and mTORC2 signaling pathways .
22837538	0	Rapamycin	0,9	mTORC1	28,34	Rapamycin	mTORC1	MESH:D020123	382056(Tax:10090)	Chemical	Gene	reverses|nsubj|START_ENTITY reverses|dobj|END_ENTITY	Rapamycin reverses elevated mTORC1 signaling in lamin_A / C-deficient mice , rescues cardiac_and_skeletal_muscle function , and extends survival .
22973301	0	Rapamycin	0,9	mTORC1	105,111	Rapamycin	mTORC1	MESH:D020123	382056(Tax:10090)	Chemical	Gene	has|nsubj|START_ENTITY has|dobj|effect effect|nmod|sensitivity sensitivity|nmod|myotubes myotubes|amod|due due|nmod|disruption disruption|nmod|END_ENTITY	Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2 .
23884148	0	Rapamycin	0,9	mTORC1	24,30	Rapamycin	mTORC1	MESH:D020123	382056(Tax:10090)	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	Rapamycin inhibition of mTORC1 reverses lithium-induced proliferation of renal collecting duct cells .
24112984	0	Rapamycin	0,9	mTORC1	22,28	Rapamycin	mTORC1	MESH:D020123	382056(Tax:10090)	Chemical	Gene	resistance|compound|START_ENTITY resistance|parataxis|hold hold|nsubj|substrates substrates|amod|END_ENTITY	Rapamycin resistance : mTORC1 substrates hold some of the answers .
24404143	0	Rapamycin	0,9	mTORC1	130,136	Rapamycin	mTORC1	MESH:D020123	382056(Tax:10090)	Chemical	Gene	ameliorates|nsubj|START_ENTITY ameliorates|nmod|inhibition inhibition|nmod|END_ENTITY	Rapamycin ameliorates inflammation and fibrosis in the early phase of cirrhotic_portal_hypertension in rats through inhibition of mTORC1 but not mTORC2 .
25738366	0	Rapamycin	0,9	mTORC1	58,64	Rapamycin	mTORC1	MESH:D020123	382056(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2 .
26002629	0	Rapamycin	0,9	mTORC1	74,80	Rapamycin	mTORC1	MESH:D020123	382056(Tax:10090)	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|dobj|neuronal_cell_death neuronal_cell_death|acl|targeting targeting|dobj|pathways pathways|amod|END_ENTITY	Rapamycin prevents cadmium-induced neuronal_cell_death via targeting both mTORC1 and mTORC2 pathways .
26740621	0	Rapamycin	68,77	mTORC1	89,95	Rapamycin	mTORC1	MESH:D020123	382056(Tax:10090)	Chemical	Gene	Target|nmod|START_ENTITY Inhibition|nmod|Target Complex|nsubj|Inhibition Complex|dobj|1 1|appos|END_ENTITY	Ubiquilin Mediated Small Molecule Inhibition of Mammalian Target of Rapamycin Complex 1 -LRB- mTORC1 -RRB- Signaling .
26755732	0	Rapamycin	22,31	mTORC1	43,49	Rapamycin	mTORC1	MESH:D020123	382056(Tax:10090)	Chemical	Gene	Target|nmod|START_ENTITY Complex|nsubj|Target Complex|dobj|1 1|appos|END_ENTITY	Mechanistic Target of Rapamycin Complex 1 -LRB- mTORC1 -RRB- and mTORC2 as Key Signaling Intermediates in Mesenchymal Cell Activation .
24516119	0	Rapamycin	0,9	mTORC2	81,87	Rapamycin	mTORC2	MESH:D020123	74343(Tax:10090)	Chemical	Gene	antagonizes|nsubj|START_ENTITY antagonizes|nmod|END_ENTITY	Rapamycin antagonizes TNF induction of VCAM-1 on endothelial cells by inhibiting mTORC2 .
25880554	0	Rapamycin	47,56	mTORC2	25,31	Rapamycin	mTORC2	MESH:D020123	74343(Tax:10090)	Chemical	Gene	Sensitivity|nmod|START_ENTITY Sensitivity|compound|END_ENTITY	17 __ - Estradiol Regulates mTORC2 Sensitivity to Rapamycin in Adaptive_Cardiac_Remodeling .
25880554	0	Rapamycin	47,56	mTORC2	25,31	Rapamycin	mTORC2	MESH:D020123	74343(Tax:10090)	Chemical	Gene	Sensitivity|nmod|START_ENTITY Sensitivity|compound|END_ENTITY	17 __ - Estradiol Regulates mTORC2 Sensitivity to Rapamycin in Adaptive_Cardiac_Remodeling .
15708965	0	Rapamycin	0,9	mammalian_target_of_rapamycin	108,137	Rapamycin	mammalian target of rapamycin	MESH:D020123	2475	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Rapamycin inhibits fibronectin-induced migration of the human arterial smooth muscle line -LRB- E47 -RRB- through the mammalian_target_of_rapamycin .
17425689	0	Rapamycin	0,9	mammalian_target_of_rapamycin	39,68	Rapamycin	mammalian target of rapamycin	MESH:D020123	2475	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Rapamycin , a specific inhibitor of the mammalian_target_of_rapamycin , suppresses lymphangiogenesis and lymphatic metastasis .
19845851	0	Rapamycin	0,9	mammalian_target_of_rapamycin	34,63	Rapamycin	mammalian target of rapamycin	MESH:D020123	2475	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|END_ENTITY	Rapamycin and CCI-779 inhibit the mammalian_target_of_rapamycin signalling in hepatocellular_carcinoma .
26362858	0	Rapamycin	0,9	p14	19,22	Rapamycin	p14	MESH:D020123	11102	Chemical	Gene	restores|nsubj|START_ENTITY restores|dobj|END_ENTITY	Rapamycin restores p14 , p15 and p57 expression and inhibits the mTOR/p70S6K pathway in acute_lymphoblastic_leukemia cells .
8109837	0	Rapamycin	0,9	p34cdc2	19,26	Rapamycin	p34cdc2	MESH:D020123	12534(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Rapamycin inhibits p34cdc2 expression and arrests T lymphocyte proliferation at the G1/S transition .
1380801	0	Rapamycin	0,9	p70_S6_kinase	42,55	Rapamycin	p70 S6 kinase	MESH:D020123	6198	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Rapamycin inhibits the phosphorylation of p70_S6_kinase in IL-2 and mitogen-activated human T cells .
7721872	0	Rapamycin	0,9	proliferating_cell_nuclear_antigen	51,85	Rapamycin	proliferating cell nuclear antigen	MESH:D020123	18538(Tax:10090)	Chemical	Gene	blocks|nsubj|START_ENTITY blocks|dobj|expression expression|compound|END_ENTITY	Rapamycin selectively blocks interleukin-2-induced proliferating_cell_nuclear_antigen gene expression in T lymphocyte .
9151781	0	Rapamycin	0,9	proliferating_cell_nuclear_antigen	31,65	Rapamycin	proliferating cell nuclear antigen	MESH:D020123	5111	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Rapamycin -LRB- sirolimus -RRB- inhibits proliferating_cell_nuclear_antigen expression and blocks cell cycle in the G1 phase in human keratinocyte stem cells .
15156944	0	Rapamycin	0,9	tumor_necrosis_factor-alpha	30,57	Rapamycin	tumor necrosis factor-alpha	MESH:D020123	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|nmod|END_ENTITY	Rapamycin inhibits release of tumor_necrosis_factor-alpha from human vascular smooth muscle cells .
23908775	0	Rasagiline	16,26	MAO-B	34,39	Rasagiline	MAO-B	MESH:C031967	4129	Chemical	Gene	Disease|nmod|START_ENTITY Disease|nsubj|Drug Drug|compound|END_ENTITY	Pharmacology of Rasagiline , a New MAO-B Inhibitor Drug for the Treatment of Parkinson 's _ Disease with Neuroprotective Potential .
18488080	0	Rasagiline	0,10	MAO_B	21,26	Rasagiline	MAO B	MESH:C031967	4129	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Rasagiline - a novel MAO_B inhibitor in Parkinson 's _ disease therapy .
10518120	0	Rasagiline	0,10	monoamine_oxidase-B	14,33	Rasagiline	monoamine oxidase-B	MESH:C031967	25750(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Rasagiline , a monoamine_oxidase-B inhibitor , protects NGF-differentiated PC12 cells against oxygen-glucose_deprivation .
20600573	0	Rasagiline	0,10	monoamine_oxidase-B	38,57	Rasagiline	monoamine oxidase-B	MESH:C031967	4129	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Rasagiline : a novel anti-Parkinsonian monoamine_oxidase-B inhibitor with neuroprotective activity .
11159700	0	Rasagiline	0,10	monoamine_oxidase_B	93,112	Rasagiline	monoamine oxidase B	MESH:C031967	25750(Tax:10116)	Chemical	Gene	N-propargyl-1R|amod|START_ENTITY N-propargyl-1R|dep|-RSB- -RSB-|appos|inhibitor inhibitor|nmod|END_ENTITY	Rasagiline -LSB- N-propargyl-1R -LRB- + -RRB- - aminoindan -RSB- , a selective and potent inhibitor of mitochondrial monoamine_oxidase_B .
16675649	0	Rasagiline	0,10	monoamine_oxidase_type-B	32,56	Rasagiline	monoamine oxidase type-B	MESH:C031967	4129	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Rasagiline : A second-generation monoamine_oxidase_type-B inhibitor for the treatment of Parkinson 's _ disease .
11575866	0	Rasagiline_mesylate	0,19	MAO-B	27,32	Rasagiline mesylate	MAO-B	null	4129	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Rasagiline_mesylate , a new MAO-B inhibitor for the treatment of Parkinson 's _ disease : a double-blind study as adjunctive therapy to levodopa .
26384002	0	Rasputin	9,17	nsP3	51,55	Rasputin	nsP3	null	10044	Chemical	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Mosquito Rasputin interacts with chikungunya_virus nsP3 and determines the infection rate in Aedes_albopictus .
26384002	0	Rasputin	9,17	nsP3	51,55	Rasputin	nsP3	null	10044	Chemical	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Mosquito Rasputin interacts with chikungunya_virus nsP3 and determines the infection rate in Aedes_albopictus .
22307937	0	Ratanhiaphenol_III	0,18	PTP1B	45,50	Ratanhiaphenol III	PTP1B	MESH:C575484	5770	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|compound|END_ENTITY	Ratanhiaphenol_III from Ratanhiae radix is a PTP1B inhibitor .
18083641	0	Rd	51,53	Rb1	55,58	Rd	Rb1	null	24708(Tax:10116)	Chemical	Gene	determination|nmod|START_ENTITY END_ENTITY|nsubj|determination	Simultaneous determination of ginsenoside_Rg1 , Re , Rd , Rb1 and ophiopogonin_D in rat plasma by liquid chromatography/electrospray ionization mass spectrometric method and its application to pharmacokinetic study of ` SHENMAI ' injection .
26703758	0	Re-Pyridyl-NHCs	37,52	CO2	28,31	Re-Pyridyl-NHCs	CO2	null	717	Chemical	Gene	Reduction|nmod|START_ENTITY Reduction|nmod|END_ENTITY	Photocatalytic Reduction of CO2 with Re-Pyridyl-NHCs .
11454909	0	Rebamipide	0,10	interleukin-8	37,50	Rebamipide	interleukin-8	MESH:C052785	3576	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Rebamipide inhibits ceramide-induced interleukin-8 production in Kato III human gastric_cancer cells .
20607584	0	Rebamipide	0,10	interleukin-8	52,65	Rebamipide	interleukin-8	MESH:C052785	3576	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Rebamipide inhibits tumor_necrosis_factor-a-induced interleukin-8 expression by suppressing the NF-kB signal pathway in human umbilical vein endothelial cells .
24639459	0	Reduced_64Cu	0,12	copper_transporter_1	70,90	Reduced 64Cu	copper transporter 1	null	1317	Chemical	Gene	uptake|amod|START_ENTITY uptake|nmod|END_ENTITY	Reduced_64Cu uptake and tumor growth inhibition by knockdown of human copper_transporter_1 in xenograft mouse model of prostate_cancer .
26419617	0	Regorafenib	40,51	Notch-1	15,22	Regorafenib	Notch-1	MESH:C559147	4851	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of Notch-1 in Resistance to Regorafenib in Colon_Cancer Cells .
17920032	0	Relaxin	0,7	MMP-2	19,24	Relaxin	MMP-2	MESH:D012065	4313	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	Relaxin stimulates MMP-2 and alpha-smooth muscle actin expression by human periodontal ligament cells .
15956747	0	Relaxin	0,7	S100A4	50,56	Relaxin	S100A4	MESH:D012065	6275	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	Relaxin downregulates the calcium binding protein S100A4 in MDA-MB-231 human breast_cancer cells .
19467703	0	Relaxin	0,7	interleukin-6	19,32	Relaxin	interleukin-6	MESH:D012065	3569	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|amod|END_ENTITY	Relaxin stimulates interleukin-6 and interleukin-8 secretion from the extraplacental chorionic cytotrophoblast .
15784719	0	Relaxin	0,7	interleukin_11	40,54	Relaxin	interleukin 11	MESH:D012065	3589	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	Relaxin and prostaglandin_E -LRB- 2 -RRB- regulate interleukin_11 during human endometrial stromal cell decidualization .
19726290	0	Remifentanil	1,13	cardiac_troponin_I	37,55	Remifentanil	cardiac troponin I	MESH:C071741	7137	Chemical	Gene	lowers|nsubj|START_ENTITY lowers|dobj|levels levels|amod|END_ENTITY	-LSB- Remifentanil preconditioning lowers cardiac_troponin_I levels in patients undergoing off-pump_coronary_artery_bypass graft surgery -RSB- .
26271274	0	Remogliflozin_etabonate	0,23	SGLT2	34,39	Remogliflozin etabonate	SGLT2	MESH:C532127	6524	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Remogliflozin_etabonate : a novel SGLT2 inhibitor for treatment of diabetes_mellitus .
26288025	0	Remogliflozin_etabonate	0,23	SGLT2	33,38	Remogliflozin etabonate	SGLT2	MESH:C532127	6524	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Remogliflozin_etabonate : a novel SGLT2 inhibitor for treatment of diabetes_mellitus .
2895483	0	Remoxipride	0,11	dopamine_D2_receptor	25,45	Remoxipride	dopamine D2 receptor	MESH:D017330	1813	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Remoxipride , a selective dopamine_D2_receptor antagonist , in tardive_dyskinesia .
2868493	0	Remoxipride	0,11	prolactin	48,57	Remoxipride	prolactin	MESH:D017330	5617	Chemical	Gene	START_ENTITY|dep|effects effects|nmod|END_ENTITY	Remoxipride in schizophrenia : effects on plasma prolactin .
18569347	0	Renierol	0,8	xanthine_oxidase	66,82	Renierol	xanthine oxidase	MESH:C531171	22436(Tax:10090)	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	Renierol from marine sponge Haliclona.SP. : a natural inhibitor of xanthine_oxidase with hypouricemic effects .
26366736	0	Renin_Gene	61,71	Renin	80,85	Renin Gene	Renin	null	5972	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	A Genetic Variant in the Distal Enhancer Region of the Human Renin_Gene Affects Renin Expression .
10834429	0	Repaglinide	0,11	insulin	40,47	Repaglinide	insulin	MESH:C072379	3630	Chemical	Gene	amplifies|amod|START_ENTITY pulsatile|nsubj|amplifies pulsatile|dobj|secretion secretion|compound|END_ENTITY	Repaglinide acutely amplifies pulsatile insulin secretion by augmentation of burst mass with no effect on burst frequency .
15029102	0	Repaglinide	0,11	insulin	50,57	Repaglinide	insulin	MESH:C072379	3630	Chemical	Gene	efficient|nsubj|START_ENTITY efficient|nmod|glimepiride glimepiride|nmod|secretion secretion|compound|END_ENTITY	Repaglinide is more efficient than glimepiride on insulin secretion and post-prandial glucose excursions in patients with type 2 diabetes .
17346425	0	Reparixin	0,9	interleukin-8	22,35	Reparixin	interleukin-8	MESH:C490707	3576	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Reparixin , a specific interleukin-8 inhibitor , has no effects on inflammation during endotoxemia .
26847910	0	Repertaxin	0,10	CXCR1	52,57	Repertaxin	CXCR1	MESH:C490707	3577	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Repertaxin , an inhibitor of the chemokine receptors CXCR1 and CXCR2 , inhibits malignant behavior of human gastric_cancer MKN45 cells in vitro and in vivo and enhances efficacy of 5-fluorouracil .
7914358	0	Reserpine	0,9	Fos	20,23	Reserpine	Fos	MESH:D012110	314322(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|activity activity|compound|END_ENTITY	Reserpine increases Fos activity in the rat basal ganglia via a quinpirole-sensitive mechanism .
8843094	0	Reserpine	0,9	c-fos	35,40	Reserpine	c-fos	MESH:D012110	14281(Tax:10090)	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|expression expression|amod|END_ENTITY	Reserpine potentiates NMDA-induced c-fos mRNA expression in the mouse brain .
1315907	0	Reserpine	0,9	neurotensin	29,40	Reserpine	neurotensin	MESH:D012110	4922	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|compound|END_ENTITY	Reserpine increases striatal neurotensin mRNA levels .
6142829	0	Reserpine	0,9	tyrosine_hydroxylase	23,43	Reserpine	tyrosine hydroxylase	MESH:D012110	7054	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Reserpine induction of tyrosine_hydroxylase in paraplegia .
14992587	0	Resiniferatoxin	0,15	capsaicin_receptor	29,47	Resiniferatoxin	capsaicin receptor	MESH:C024353	7442	Chemical	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Resiniferatoxin binds to the capsaicin_receptor -LRB- TRPV1 -RRB- near the extracellular side of the S4 transmembrane domain .
24667608	0	Resistin	0,8	plasminogen_activator_inhibitor-1	37,70	Resistin	plasminogen activator inhibitor-1	MESH:D052243	5054	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Resistin regulates the expression of plasminogen_activator_inhibitor-1 in 3T3-L1 adipocytes .
24065624	0	Resminostat	69,80	histone_deacetylase	90,109	Resminostat	histone deacetylase	MESH:C550599	9734	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	First-in-human , pharmacokinetic and pharmacodynamic phase I study of Resminostat , an oral histone_deacetylase inhibitor , in patients with advanced solid tumors .
24451959	0	Resolvin-D1	0,11	interleukin-8	21,34	Resolvin-D1	interleukin-8	MESH:C518399	3576	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Resolvin-D1 inhibits interleukin-8 and hydrogen_peroxide production induced by cigarette_smoke_extract in 16HBE cells via attenuating NF-kB activation .
17339491	0	Resolvin_E1	0,11	BLT1	63,67	Resolvin E1	BLT1	MESH:C499823	1241	Chemical	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Resolvin_E1 selectively interacts with leukotriene B4 receptor BLT1 and ChemR23 to regulate inflammation .
17339491	0	Resolvin_E1	0,11	BLT1	63,67	Resolvin E1	BLT1	MESH:C499823	1241	Chemical	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Resolvin_E1 selectively interacts with leukotriene B4 receptor BLT1 and ChemR23 to regulate inflammation .
21931821	0	Resveratrol	0,11	AKT	50,53	Resveratrol	AKT	MESH:C059514	207	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|activation activation|nmod|END_ENTITY	Resveratrol suppresses constitutive activation of AKT via generation of ROS and induces apoptosis in diffuse_large_B_cell_lymphoma cell lines .
18850225	0	Resveratrol	0,11	AMPK	58,62	Resveratrol	AMPK	MESH:C059514	5563	Chemical	Gene	protects|nsubj|START_ENTITY protects|advcl|activating activating|dobj|END_ENTITY	Resveratrol protects ROS-induced cell death by activating AMPK in H9c2 cardiac muscle cells .
24535859	0	Resveratrol	0,11	AMPK	48,52	Resveratrol	AMPK	MESH:C059514	78975(Tax:10116)	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	Resveratrol , an activator of SIRT1 , upregulates AMPK and improves cardiac function in heart_failure .
26054749	0	Resveratrol	0,11	AMPK	97,101	Resveratrol	AMPK	MESH:C059514	78975(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|nmod|END_ENTITY	Resveratrol attenuates high glucose-induced oxidative stress and cardiomyocyte apoptosis through AMPK .
21479363	0	Resveratrol	0,11	ASPP1	87,92	Resveratrol	ASPP1	MESH:C059514	23368	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|up-regulation up-regulation|nmod|END_ENTITY	Resveratrol induces apoptosis in breast_cancer cells by E2F1-mediated up-regulation of ASPP1 .
23770099	0	Resveratrol	0,11	ATPase	22,28	Resveratrol	ATPase	MESH:C059514	1769	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activity activity|amod|END_ENTITY	Resveratrol modulates ATPase activity of liposome-reconstituted ABCG1 .
15849355	0	Resveratrol	0,11	Akt	74,77	Resveratrol	Akt	MESH:C059514	24185(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|compound|END_ENTITY	Resveratrol inhibits angiotensin_II - and epidermal_growth_factor-mediated Akt activation : role of Gab1 and Shp2 .
23359184	0	Resveratrol	0,11	BCL-2	93,98	Resveratrol	BCL-2	MESH:C059514	596	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|inhibiting inhibiting|dobj|regulation regulation|nmod|expression expression|compound|END_ENTITY	Resveratrol induces apoptosis of pancreatic_cancers cells by inhibiting miR-21 regulation of BCL-2 expression .
12838319	0	Resveratrol	0,11	BRCA1	22,27	Resveratrol	BRCA1	MESH:C059514	672	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Resveratrol increases BRCA1 and BRCA2 mRNA expression in breast_tumour cell lines .
18584328	0	Resveratrol	0,11	Bcl-2	89,94	Resveratrol	Bcl-2	MESH:C059514	596	Chemical	Gene	disrupts|amod|START_ENTITY disrupts|dep|role role|nmod|END_ENTITY	Resveratrol disrupts peroxynitrite-triggered mitochondrial apoptotic pathway : a role for Bcl-2 .
22410291	0	Resveratrol	0,11	Bcl-2	111,116	Resveratrol	Bcl-2	MESH:C059514	24224(Tax:10116)	Chemical	Gene	attenuates|amod|START_ENTITY brain_damage|nsubj|attenuates brain_damage|nmod|model model|nmod|cerebral_ischemia cerebral_ischemia|nmod|up-regulation up-regulation|nmod|END_ENTITY	Resveratrol attenuates brain_damage in a rat model of focal cerebral_ischemia via up-regulation of hippocampal Bcl-2 .
26819684	0	Resveratrol	26,37	Bcl-2	110,115	Resveratrol	Bcl-2	MESH:C059514	24224(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|Injury Injury|nmod|Levels Levels|dep|END_ENTITY	Neuroprotective Effect of Resveratrol on Acute Brain_Ischemia Reperfusion Injury by Measuring Annexin_V , p53 , Bcl-2 Levels in Rats .
17499741	0	Resveratrol	0,11	CCR2	101,105	Resveratrol	CCR2	MESH:C059514	729230	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	Resveratrol inhibits expression and binding activity of the monocyte_chemotactic_protein-1_receptor , CCR2 , on THP-1 monocytes .
16474181	0	Resveratrol	0,11	COX-2	57,62	Resveratrol	COX-2	MESH:C059514	19225(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Resveratrol inhibits phorbol_ester-induced expression of COX-2 and activation of NF-kappaB in mouse skin by blocking IkappaB kinase activity .
18446786	0	Resveratrol	0,11	COX-2	19,24	Resveratrol	COX-2	MESH:C059514	5743	Chemical	Gene	causes|nsubj|START_ENTITY causes|dobj|apoptosis apoptosis|amod|END_ENTITY	Resveratrol causes COX-2 - and p53-dependent apoptosis in head and neck squamous_cell_cancer cells .
15142886	0	Resveratrol	0,11	CYP1A1	48,54	Resveratrol	CYP1A1	MESH:C059514	1543	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Resveratrol inhibits TCDD-induced expression of CYP1A1 and CYP1B1 and catechol_estrogen-mediated oxidative DNA damage in cultured human mammary epithelial cells .
19376845	0	Resveratrol	0,11	CYP1A1	56,62	Resveratrol	CYP1A1	MESH:C059514	1543	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Resveratrol inhibits dioxin-induced expression of human CYP1A1 and CYP1B1 by inhibiting recruitment of the aryl_hydrocarbon_receptor complex and RNA polymerase II to the regulatory regions of the corresponding genes .
25372667	0	Resveratrol	103,114	CYP1A1	27,33	Resveratrol	CYP1A1	MESH:C059514	1543	Chemical	Gene	Hesperidin|appos|START_ENTITY Liver|nmod|Hesperidin Mechanism|nmod|Liver Mechanism|nmod|Activities Activities|compound|END_ENTITY	Mechanism of Inhibition of CYP1A1 and Glutathione_S-Transferase Activities in Fish Liver by Quercetin , Resveratrol , Naringenin , Hesperidin , and Rutin .
9865727	0	Resveratrol	0,11	CYP1A1	38,44	Resveratrol	CYP1A1	MESH:C059514	1543	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|transcription transcription|nmod|END_ENTITY	Resveratrol inhibits transcription of CYP1A1 in vitro by preventing activation of the aryl_hydrocarbon_receptor .
26680654	0	Resveratrol	0,11	CYP2E1	33,39	Resveratrol	CYP2E1	MESH:C059514	1571	Chemical	Gene	Activity|compound|START_ENTITY Activity|compound|END_ENTITY	Resveratrol Pretreatment Affects CYP2E1 Activity of Chlorzoxazone in Healthy Human Volunteers .
15217905	0	Resveratrol	0,11	Cdc42	51,56	Resveratrol	Cdc42	MESH:C059514	998	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|amod|END_ENTITY	Resveratrol induces FasL-related apoptosis through Cdc42 activation of ASK1/JNK-dependent signaling pathway in human leukemia HL-60 cells .
21736731	0	Resveratrol	0,11	Cdk5	21,25	Resveratrol	Cdk5	MESH:C059514	140908(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Resveratrol inhibits Cdk5 activity through regulation of p35 expression .
17007354	0	Resveratrol	1,12	EMMPRIN	36,43	Resveratrol	EMMPRIN	MESH:C059514	682	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	-LSB- Resveratrol inhibits expression of EMMPRIN from macrophages -RSB- .
17055343	0	Resveratrol	0,11	EMMPRIN	46,53	Resveratrol	EMMPRIN	MESH:C059514	682	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Resveratrol inhibits macrophage expression of EMMPRIN by activating PPARgamma .
18647594	0	Resveratrol	0,11	EMMPRIN	21,28	Resveratrol	EMMPRIN	MESH:C059514	682	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Resveratrol inhibits EMMPRIN expression via P38 and ERK1/2 pathways in PMA-induced THP-1 cells .
23554738	0	Resveratrol	0,11	ERK1/2	44,50	Resveratrol	ERK1/2	MESH:C059514	50689;116590	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|compound|END_ENTITY	Resveratrol inhibits angiotensin_II-induced ERK1/2 activation by downregulating quinone_reductase_2 in rat vascular smooth muscle cells .
25645941	0	Resveratrol	0,11	Egr-1	24,29	Resveratrol	Egr-1	MESH:C059514	1958	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	Resveratrol upregulates Egr-1 expression and activity involving extracellular signal-regulated protein kinase and ternary complex factors .
21418583	0	Resveratrol	0,11	FOXO1	107,112	Resveratrol	FOXO1	MESH:C059514	2308	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|cytotoxicity cytotoxicity|acl|induced induced|nmod|inhibitors inhibitors|nmod|induction induction|nmod|END_ENTITY	Resveratrol protects leukemic cells against cytotoxicity induced by proteasome inhibitors via induction of FOXO1 and p27Kip1 .
25158994	0	Resveratrol	0,11	FOXO3	21,26	Resveratrol	FOXO3	MESH:C059514	294515(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|compound|END_ENTITY	Resveratrol enhanced FOXO3 phosphorylation via synergetic activation of SIRT1 and PI3K/Akt signaling to improve the effects of exercise in elderly rat hearts .
21673955	0	Resveratrol	0,11	GLP-1	38,43	Resveratrol	GLP-1	MESH:C059514	14526(Tax:10090)	Chemical	Gene	secretion|amod|START_ENTITY secretion|compound|END_ENTITY	Resveratrol increases glucose induced GLP-1 secretion in mice : a mechanism which contributes to the glycemic control .
26088684	0	Resveratrol	0,11	HO-1	86,90	Resveratrol	HO-1	MESH:C059514	3162	Chemical	Gene	Astrocytes|compound|START_ENTITY Pathways|nsubj|Astrocytes Pathways|nmod|END_ENTITY	Resveratrol Protects Hippocampal Astrocytes Against LPS-Induced Neurotoxicity Through HO-1 , p38 and ERK Pathways .
16150460	0	Resveratrol	0,11	ICAM-1	36,42	Resveratrol	ICAM-1	MESH:C059514	3383	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Resveratrol suppresses IL-6-induced ICAM-1 gene expression in endothelial cells : effects on the inhibition of STAT3 phosphorylation .
19331173	0	Resveratrol	0,11	ICAM-1	74,80	Resveratrol	ICAM-1	MESH:C059514	3383	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|blocking blocking|dobj|expression expression|compound|END_ENTITY	Resveratrol inhibits tumor cell adhesion to endothelial cells by blocking ICAM-1 expression .
23328930	0	Resveratrol	0,11	IL-1b	35,40	Resveratrol	IL-1b	MESH:C059514	3553	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Resveratrol inhibits TNF-a-induced IL-1b , MMP-3 production in human rheumatoid_arthritis fibroblast-like synoviocytes via modulation of PI3kinase/Akt pathway .
17630201	0	Resveratrol	0,11	IL-6	42,46	Resveratrol	IL-6	MESH:C059514	16193(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Resveratrol induces apoptosis , influences IL-6 and exerts immunomodulatory effect on mouse lymphocytic_leukemia both in vitro and in vivo .
23844973	0	Resveratrol	0,11	IL-6	46,50	Resveratrol	IL-6	MESH:C059514	3569	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|production production|compound|END_ENTITY	Resveratrol , a sirtuin_1 activator , increases IL-6 production by peripheral blood mononuclear cells of patients with knee_osteoarthritis .
26687643	0	Resveratrol	0,11	IL-6	20,24	Resveratrol	IL-6	MESH:C059514	3569	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|secretion secretion|amod|END_ENTITY	Resveratrol reduces IL-6 and VEGF secretion from co-cultured A549 lung_cancer cells and adipose-derived mesenchymal stem cells .
23527233	0	Resveratrol	0,11	IL-8	33,37	Resveratrol	IL-8	MESH:C059514	3576	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Resveratrol induces long-lasting IL-8 expression and peculiar EGFR activation/distribution in human keratinocytes : mechanisms and implications for skin administration .
24911970	0	Resveratrol	0,11	Klotho	33,39	Resveratrol	Klotho	MESH:C059514	83504(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Resveratrol increases anti-aging Klotho gene expression via the activating_transcription_factor_3 / c-Jun complex-mediated signaling pathway .
16901463	0	Resveratrol	0,11	LXR-alpha	40,49	Resveratrol	LXR-alpha	MESH:C059514	10062	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Resveratrol regulates the expression of LXR-alpha in human macrophages .
26410971	0	Resveratrol	10,21	Leptin	25,31	Resveratrol	Leptin	MESH:C059514	25608(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|Expression Expression|compound|END_ENTITY	Effect of Resveratrol on Leptin and Sirtuin_2 Expression in the Kidneys in Streptozotocin-induced Diabetic Rats .
21878744	0	Resveratrol	0,11	MCP-1	50,55	Resveratrol	MCP-1	MESH:C059514	6347	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Resveratrol inhibits monocytic cell chemotaxis to MCP-1 and prevents spontaneous endothelial cell migration through Rho kinase-dependent mechanism .
16761963	0	Resveratrol	0,11	MEK1	90,94	Resveratrol	MEK1	MESH:C059514	5604	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Resveratrol inhibits proliferation of human epidermoid_carcinoma A431 cells by modulating MEK1 and AP-1 signalling pathways .
23328930	0	Resveratrol	0,11	MMP-3	42,47	Resveratrol	MMP-3	MESH:C059514	4314	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|IL-1b IL-1b|appos|production production|compound|END_ENTITY	Resveratrol inhibits TNF-a-induced IL-1b , MMP-3 production in human rheumatoid_arthritis fibroblast-like synoviocytes via modulation of PI3kinase/Akt pathway .
24840287	0	Resveratrol	0,11	MMP-3	56,61	Resveratrol	MMP-3	MESH:C059514	4314	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Resveratrol inhibits oxygen-glucose_deprivation-induced MMP-3 expression and cell apoptosis in primary cortical cells via the NF-kB pathway .
26946533	0	Resveratrol	0,11	MMP-3	37,42	Resveratrol	MMP-3	MESH:C059514	4314	Chemical	Gene	attenuated|nsubj|START_ENTITY attenuated|dobj|expression expression|compound|END_ENTITY	Resveratrol attenuated TNF-a-induced MMP-3 expression in human nucleus pulposus cells by activating autophagy via AMPK/SIRT1 signaling pathway .
16321402	0	Resveratrol	0,11	MMP-9	42,47	Resveratrol	MMP-9	MESH:C059514	17395(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|level level|nmod|END_ENTITY	Resveratrol reduces the elevated level of MMP-9 induced by cerebral_ischemia-reperfusion in mice .
19135132	0	Resveratrol	0,11	MMP-9	21,26	Resveratrol	MMP-9	MESH:C059514	4318	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Resveratrol inhibits MMP-9 expression by up-regulating PPAR_alpha expression in an oxygen glucose deprivation-exposed neuron model .
22523472	0	Resveratrol	0,11	MMP-9	91,96	Resveratrol	MMP-9	MESH:C059514	4318	Chemical	Gene	Targeting|compound|START_ENTITY Targeting|nmod|Biomarkers Biomarkers|amod|END_ENTITY	Resveratrol Targeting of Carcinogen-Induced Brain Endothelial Cell Inflammation Biomarkers MMP-9 and COX-2 is Sirt1-Independent .
23229870	0	Resveratrol	0,11	MMP-9	20,25	Resveratrol	MMP-9	MESH:C059514	4318	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|migration migration|compound|END_ENTITY	Resveratrol induces MMP-9 and cell migration via the p38 kinase and PI-3K pathways in HT1080 human fibrosarcoma cells .
24682241	0	Resveratrol	0,11	MMP-9	110,115	Resveratrol	MMP-9	MESH:C059514	17395(Tax:10090)	Chemical	Gene	protects|nsubj|START_ENTITY protects|advcl|inhibiting inhibiting|dobj|END_ENTITY	Resveratrol protects primary cortical neuron cultures from transient oxygen-glucose_deprivation by inhibiting MMP-9 .
25330860	0	Resveratrol	0,11	MMP-9	80,85	Resveratrol	MMP-9	MESH:C059514	81687(Tax:10116)	Chemical	Gene	Attenuates|nsubj|START_ENTITY Attenuates|dobj|Dysfunction Dysfunction|nmod|Regulation Regulation|nmod|Balance Balance|compound|END_ENTITY	Resveratrol Attenuates the Blood-Brain Barrier Dysfunction by Regulation of the MMP-9 / TIMP-1 Balance after Cerebral_Ischemia Reperfusion in Rats .
21689630	0	Resveratrol	0,11	MRP2	72,76	Resveratrol	MRP2	MESH:C059514	1244	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Resveratrol inhibits genistein-induced multi-drug resistance protein 2 -LRB- MRP2 -RRB- expression in HepG2 cells .
26502886	0	Resveratrol	41,52	MRP2	92,96	Resveratrol	MRP2	MESH:C059514	20308(Tax:10090)	Chemical	Gene	Disposition|nmod|START_ENTITY Phase|dobj|Disposition Phase|nmod|END_ENTITY	Curcumin Affects Phase II Disposition of Resveratrol Through Inhibiting Efflux Transporters MRP2 and BCRP .
26443543	0	Resveratrol	21,32	MnSOD	74,79	Resveratrol	MnSOD	MESH:C059514	6648	Chemical	Gene	Expression|amod|START_ENTITY Expression|nmod|END_ENTITY	ERK5/HDAC5-Mediated , Resveratrol - and Pterostilbene-Induced Expression of MnSOD in Human Endothelial Cells .
23344064	0	Resveratrol	0,11	Myosin_light_chain_kinase	27,52	Resveratrol	Myosin light chain kinase	MESH:C059514	288057(Tax:10116)	Chemical	Gene	down-regulates|amod|START_ENTITY END_ENTITY|nsubj|down-regulates	Resveratrol down-regulates Myosin_light_chain_kinase , induces apoptosis and inhibits diethylnitrosamine-induced liver_tumorigenesis in rats .
24603648	0	Resveratrol	0,11	NAMPT	37,42	Resveratrol	NAMPT	MESH:C059514	10135	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Resveratrol differentially regulates NAMPT and SIRT1 in Hepatocarcinoma cells and primary human hepatocytes .
12689943	0	Resveratrol	0,11	NF-kappaB	92,101	Resveratrol	NF-kappaB	MESH:C059514	4790	Chemical	Gene	blocks|nsubj|START_ENTITY blocks|dobj|activation activation|nmod|END_ENTITY	Resveratrol blocks interleukin-1beta-induced activation of the nuclear transcription factor NF-kappaB , inhibits proliferation , causes S-phase arrest , and induces apoptosis of acute_myeloid_leukemia cells .
16474181	0	Resveratrol	0,11	NF-kappaB	81,90	Resveratrol	NF-kappaB	MESH:C059514	18033(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Resveratrol inhibits phorbol_ester-induced expression of COX-2 and activation of NF-kappaB in mouse skin by blocking IkappaB kinase activity .
16973825	0	Resveratrol	0,11	NF-kappaB	100,109	Resveratrol	NF-kappaB	MESH:C059514	4790	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|activation activation|dep|role role|nmod|inhibition inhibition|amod|END_ENTITY	Resveratrol attenuates TNF-alpha-induced activation of coronary arterial endothelial cells : role of NF-kappaB inhibition .
18951995	0	Resveratrol	0,11	NHE-1	40,45	Resveratrol	NHE-1	MESH:C059514	6548	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Resveratrol regulates the expression of NHE-1 by repressing its promoter activity : critical involvement of intracellular H2O2 and caspases 3 and 6 in the absence of cell death .
23523995	0	Resveratrol	0,11	Nrf-2	81,86	Resveratrol	Nrf-2	MESH:C059514	83619(Tax:10116)	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|END_ENTITY	Resveratrol protects spinal cord dorsal column from hypoxic_injury by activating Nrf-2 .
18162601	0	Resveratrol	0,11	Nrf2	59,63	Resveratrol	Nrf2	MESH:C059514	4780	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells .
18616940	0	Resveratrol	0,11	Nrf2	96,100	Resveratrol	Nrf2	MESH:C059514	83619(Tax:10116)	Chemical	Gene	protects|nsubj|START_ENTITY protects|dobj|hepatocytes hepatocytes|dep|activation activation|nmod|factor factor|amod|END_ENTITY	Resveratrol protects primary rat hepatocytes against oxidative stress damage : activation of the Nrf2 transcription factor and augmented activities of antioxidant enzymes .
20418481	0	Resveratrol	0,11	Nrf2	98,102	Resveratrol	Nrf2	MESH:C059514	18024(Tax:10090)	Chemical	Gene	confers|nsubj|START_ENTITY confers|dobj|protection protection|nmod|activation activation|nmod|END_ENTITY	Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2 .
21697273	0	Resveratrol	0,11	Nrf2	21,25	Resveratrol	Nrf2	MESH:C059514	4780	Chemical	Gene	restores|nsubj|START_ENTITY restores|dobj|level level|amod|END_ENTITY	Resveratrol restores Nrf2 level and prevents ethanol-induced toxic effects in the cerebellum of a rodent model of fetal_alcohol_spectrum_disorders .
21850487	0	Resveratrol	0,11	Nrf2	112,116	Resveratrol	Nrf2	MESH:C059514	83619(Tax:10116)	Chemical	Gene	pretreatment|amod|START_ENTITY attenuates|nsubj|pretreatment attenuates|advcl|upregulating upregulating|dobj|expression expression|nmod|END_ENTITY	Resveratrol pretreatment attenuates cerebral ischemic_injury by upregulating expression of transcription factor Nrf2 and HO-1 in rats .
22917016	0	Resveratrol	0,11	Nrf2	24,28	Resveratrol	Nrf2	MESH:C059514	4780	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Resveratrol upregulates Nrf2 expression to attenuate methylglyoxal-induced insulin resistance in Hep G2 cells .
23894482	0	Resveratrol	0,11	Nrf2	69,73	Resveratrol	Nrf2	MESH:C059514	4780	Chemical	Gene	alleviates|nsubj|START_ENTITY alleviates|dobj|myocardial_toxicity myocardial_toxicity|nmod|factor factor|amod|END_ENTITY	Resveratrol alleviates endotoxin-induced myocardial_toxicity via the Nrf2 transcription factor .
24642904	0	Resveratrol	0,11	Nrf2	64,68	Resveratrol	Nrf2	MESH:C059514	83619(Tax:10116)	Chemical	Gene	encapsulated|amod|START_ENTITY activates|nsubj|encapsulated activates|dobj|stress stress|amod|END_ENTITY	Resveratrol encapsulated in novel fusogenic liposomes activates Nrf2 and attenuates oxidative stress in cerebromicrovascular endothelial cells from aged rats .
25761698	0	Resveratrol	0,11	Nrf2	21,25	Resveratrol	Nrf2	MESH:C059514	83619(Tax:10116)	Chemical	Gene	restored|nsubj|START_ENTITY restored|dobj|function function|amod|END_ENTITY	Resveratrol restored Nrf2 function , reduced renal_inflammation , and mitigated hypertension in spontaneously hypertensive rats .
26460589	0	Resveratrol	0,11	P-Glycoprotein	85,99	Resveratrol	P-Glycoprotein	MESH:C059514	5243	Chemical	Gene	Increases|nsubj|START_ENTITY Increases|nmod|Expression Expression|compound|END_ENTITY	Resveratrol Increases Anti-Proliferative Activity of Bestatin through Downregulating P-Glycoprotein Expression via Inhibiting PI3K/Akt/mTOR Pathway in K562/ADR Cells .
23819014	0	Resveratrol	0,11	PAI-1	23,28	Resveratrol	PAI-1	MESH:C059514	5054	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Resveratrol suppresses PAI-1 gene expression in a human in vitro model of inflamed adipose tissue .
14739659	0	Resveratrol	0,11	PKC_alpha	143,152	Resveratrol	PKC alpha	MESH:C059514	5578	Chemical	Gene	antagonizes|nsubj|START_ENTITY antagonizes|dobj|activation activation|nmod|cells cells|nmod|inhibition inhibition|compound|END_ENTITY	Resveratrol antagonizes EGFR-dependent Erk1/2 activation in human androgen-independent prostate_cancer cells with associated isozyme-selective PKC_alpha inhibition .
15744586	0	Resveratrol	0,11	PKC_alpha	31,40	Resveratrol	PKC alpha	MESH:C059514	5578	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Resveratrol regulates cellular PKC_alpha and delta to inhibit growth and induce apoptosis in gastric_cancer cells .
24478552	0	Resveratrol	10,21	PON1	38,42	Resveratrol	PON1	MESH:C059514	5444	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|Expression Expression|compound|END_ENTITY	Effect of Resveratrol and Nicotine on PON1 Gene Expression : In Vitro Study .
19135132	0	Resveratrol	0,11	PPAR_alpha	55,65	Resveratrol	PPAR alpha	MESH:C059514	5465	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|expression expression|compound|END_ENTITY	Resveratrol inhibits MMP-9 expression by up-regulating PPAR_alpha expression in an oxygen glucose deprivation-exposed neuron model .
17055343	0	Resveratrol	0,11	PPARgamma	68,77	Resveratrol	PPARgamma	MESH:C059514	5468	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|activating activating|dobj|END_ENTITY	Resveratrol inhibits macrophage expression of EMMPRIN by activating PPARgamma .
21248286	0	Resveratrol	0,11	PTGS2	40,45	Resveratrol	PTGS2	MESH:C059514	29527(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	Resveratrol modulates the expression of PTGS2 and cellular proliferation in the normal rat endometrium in an AKT-dependent manner .
25875864	0	Resveratrol	0,11	Pokemon	22,29	Resveratrol	Pokemon	MESH:C059514	51341	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Resveratrol Represses Pokemon Expression in Human Glioma Cells .
26041665	0	Resveratrol	12,23	Pokemon	34,41	Resveratrol	Pokemon	MESH:C059514	51341	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Erratum to : Resveratrol Represses Pokemon Expression in Human Glioma Cells .
25550561	0	Resveratrol	0,11	Protein_Kinase_G	70,86	Resveratrol	Protein Kinase G	MESH:C059514	5592	Chemical	Gene	START_ENTITY|nmod|Signaling Signaling|compound|END_ENTITY	Resveratrol at Anti-angiogenesis/Anticancer Concentrations Suppresses Protein_Kinase_G Signaling and Decreases IAPs Expression in HUVECs .
22174926	0	Resveratrol	0,11	RNA_processing_factor	27,48	Resveratrol	RNA processing factor	MESH:C059514	88745	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Resveratrol , by modulating RNA_processing_factor levels , can influence the alternative splicing of pre-mRNAs .
19355928	0	Resveratrol	0,11	SIRT1	58,63	Resveratrol	SIRT1	MESH:C059514	309757(Tax:10116)	Chemical	Gene	START_ENTITY|dep|activation activation|nmod|END_ENTITY	Resveratrol and neurodegenerative_diseases : activation of SIRT1 as the potential pathway towards neuroprotection .
19843076	0	Resveratrol	0,11	SIRT1	41,46	Resveratrol	SIRT1	MESH:C059514	23411	Chemical	Gene	activator|nsubj|START_ENTITY activator|nmod|activity activity|compound|END_ENTITY	Resveratrol is not a direct activator of SIRT1 enzyme activity .
19843076	1	Resveratrol	64,75	SIRT1	251,256	Resveratrol	SIRT1	MESH:C059514	23411	Chemical	Gene	plant|nsubj|START_ENTITY plant|acl|exerting exerting|dobj|effects effects|acl:relcl|thought thought|xcomp|mediated mediated|nmod|END_ENTITY	Resveratrol is a plant polyphenol capable of exerting beneficial metabolic effects which are thought to be mediated in large by the activation of the NAD -LRB- + -RRB- - dependent protein deacetylase SIRT1 .
20008278	0	Resveratrol	0,11	SIRT1	29,34	Resveratrol	SIRT1	MESH:C059514	23411	Chemical	Gene	START_ENTITY|appos|activator activator|nmod|END_ENTITY	Resveratrol , an activator of SIRT1 , upregulates sarcoplasmic calcium ATPase and improves cardiac function in diabetic_cardiomyopathy .
20872255	0	Resveratrol	0,11	SIRT1	24,29	Resveratrol	SIRT1	MESH:C059514	23411	Chemical	Gene	upregulated|nsubj|START_ENTITY upregulated|dobj|END_ENTITY	Resveratrol upregulated SIRT1 , FOXO1 , and adiponectin and downregulated PPARy1-3 mRNA expression in human visceral adipocytes .
21238464	0	Resveratrol	0,11	SIRT1	90,95	Resveratrol	SIRT1	MESH:C059514	23411	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|metalloproteinase metalloproteinase|nmod|modulation modulation|nmod|END_ENTITY	Resveratrol with antioxidant activity inhibits matrix metalloproteinase via modulation of SIRT1 in human fibrosarcoma cells .
21479886	0	Resveratrol	0,11	SIRT1	20,25	Resveratrol	SIRT1	MESH:C059514	23411	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|inhibition inhibition|amod|END_ENTITY	Resveratrol induces SIRT1 - and energy-stress-independent inhibition of tumor cell regrowth after low-dose platinum treatment .
21520490	0	Resveratrol	0,11	SIRT1	135,140	Resveratrol	SIRT1	MESH:C059514	93759(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|induction induction|nmod|apoptosis apoptosis|nmod|regulation regulation|nmod|END_ENTITY	Resveratrol -LRB- trans-3 ,5,4 ' - trihydroxystilbene -RRB- suppresses EL4_tumor growth by induction of apoptosis involving reciprocal regulation of SIRT1 and NF-kB .
21813271	0	Resveratrol	0,11	SIRT1	25,30	Resveratrol	SIRT1	MESH:C059514	23411	Chemical	Gene	up-regulates|amod|START_ENTITY END_ENTITY|nsubj|up-regulates	Resveratrol up-regulates SIRT1 and inhibits cellular oxidative stress in the diabetic milieu : mechanistic insights .
22015446	0	Resveratrol	0,11	SIRT1	98,103	Resveratrol	SIRT1	MESH:C059514	309757(Tax:10116)	Chemical	Gene	protects|nsubj|START_ENTITY protects|advcl|activating activating|dobj|END_ENTITY	Resveratrol protects against hyperglycemia-induced oxidative damage to mitochondria by activating SIRT1 in rat mesangial cells .
22044919	0	Resveratrol	0,11	SIRT1	128,133	Resveratrol	SIRT1	MESH:C059514	23411	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|activating activating|dobj|END_ENTITY	Resveratrol inhibits interleukin_1b-mediated inducible_nitric_oxide_synthase expression in articular chondrocytes by activating SIRT1 and thereby suppressing nuclear factor-kB activity .
22357324	0	Resveratrol	0,11	SIRT1	105,110	Resveratrol	SIRT1	MESH:C059514	309757(Tax:10116)	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|dep|role role|nmod|END_ENTITY	Resveratrol promotes expression of SIRT1 and StAR in rat ovarian granulosa cells : an implicative role of SIRT1 in the ovary .
22357324	0	Resveratrol	0,11	SIRT1	35,40	Resveratrol	SIRT1	MESH:C059514	309757(Tax:10116)	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|nmod|END_ENTITY	Resveratrol promotes expression of SIRT1 and StAR in rat ovarian granulosa cells : an implicative role of SIRT1 in the ovary .
23127402	0	Resveratrol	1,12	SIRT1	114,119	Resveratrol	SIRT1	MESH:C059514	23411	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|synthesis synthesis|nmod|cells cells|nmod|upregulation upregulation|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Resveratrol stimulates extracellular matrix synthesis in degenerative nucleus pulposus cells via upregulation of SIRT1 -RSB- .
23297412	0	Resveratrol	0,11	SIRT1	73,78	Resveratrol	SIRT1	MESH:C059514	93759(Tax:10090)	Chemical	Gene	improves|nsubj|START_ENTITY improves|nmod|modulation modulation|nummod|END_ENTITY	Resveratrol improves cardiomyopathy in dystrophin-deficient mice through SIRT1 protein-mediated modulation of p300 protein .
23792339	0	Resveratrol	0,11	SIRT1	29,34	Resveratrol	SIRT1	MESH:C059514	309757(Tax:10116)	Chemical	Gene	START_ENTITY|appos|activator activator|nmod|END_ENTITY	Resveratrol , an activator of SIRT1 , restores erectile function in streptozotocin-induced diabetic rats .
23880858	0	Resveratrol	0,11	SIRT1	85,90	Resveratrol	SIRT1	MESH:C059514	23411	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|ccomp|ionising ionising|advcl|activating activating|dobj|END_ENTITY	Resveratrol inhibits ionising irradiation-induced inflammation in MSCs by activating SIRT1 and limiting NLRP-3 inflammasome activation .
23891692	0	Resveratrol	0,11	SIRT1	66,71	Resveratrol	SIRT1	MESH:C059514	23411	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|biogenesis biogenesis|compound|END_ENTITY	Resveratrol protects cardiomyocytes from oxidative stress through SIRT1 and mitochondrial biogenesis signaling pathways .
24395567	0	Resveratrol	0,11	SIRT1	32,37	Resveratrol	SIRT1	MESH:C059514	309757(Tax:10116)	Chemical	Gene	restores|nsubj|START_ENTITY restores|dobj|activity activity|appos|END_ENTITY	Resveratrol restores sirtuin_1 -LRB- SIRT1 -RRB- activity and pyruvate_dehydrogenase_kinase_1 -LRB- PDK1 -RRB- expression after hemorrhagic_injury in a rat model .
24468941	0	Resveratrol	0,11	SIRT1	79,84	Resveratrol	SIRT1	MESH:C059514	93759(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|ccomp|markers markers|advcl|increasing increasing|dobj|expenditure expenditure|compound|END_ENTITY	Resveratrol increases brown adipose tissue thermogenesis markers by increasing SIRT1 and energy expenditure and decreasing fat accumulation in adipose tissue of mice fed a standard diet .
24535859	0	Resveratrol	0,11	SIRT1	29,34	Resveratrol	SIRT1	MESH:C059514	309757(Tax:10116)	Chemical	Gene	START_ENTITY|appos|activator activator|nmod|END_ENTITY	Resveratrol , an activator of SIRT1 , upregulates AMPK and improves cardiac function in heart_failure .
24561089	0	Resveratrol	0,11	SIRT1	62,67	Resveratrol	SIRT1	MESH:C059514	309757(Tax:10116)	Chemical	Gene	attenuates|amod|START_ENTITY morphine|nsubj|attenuates morphine|dobj|tolerance tolerance|nmod|regulation regulation|nummod|END_ENTITY	Resveratrol attenuates morphine antinociceptive tolerance via SIRT1 regulation in the rat spinal cord .
25158994	0	Resveratrol	0,11	SIRT1	72,77	Resveratrol	SIRT1	MESH:C059514	309757(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Resveratrol enhanced FOXO3 phosphorylation via synergetic activation of SIRT1 and PI3K/Akt signaling to improve the effects of exercise in elderly rat hearts .
25302422	0	Resveratrol	22,33	SIRT1	92,97	Resveratrol	SIRT1	MESH:C059514	93759(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|Modulation Modulation|compound|END_ENTITY	Protective Effects of Resveratrol on Hepatotoxicity Induced by Isoniazid and Rifampicin via SIRT1 Modulation .
25312218	0	Resveratrol	0,11	SIRT1	90,95	Resveratrol	SIRT1	MESH:C059514	23411	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|responses responses|nmod|cells cells|nmod|manner manner|compound|END_ENTITY	Resveratrol suppresses the inflammatory responses of human gingival epithelial cells in a SIRT1 independent manner .
25924011	0	Resveratrol	0,11	SIRT1	80,85	Resveratrol	SIRT1	MESH:C059514	23411	Chemical	Gene	Senescence|compound|START_ENTITY Associated|nsubj|Senescence Associated|nmod|END_ENTITY	Resveratrol Induced Premature Senescence Is Associated with DNA Damage Mediated SIRT1 and SIRT2 Down-Regulation .
25940282	0	Resveratrol	1,12	SIRT1	76,81	Resveratrol	SIRT1	MESH:C059514	23411	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|expression expression|compound|END_ENTITY	-LSB- Resveratrol inhibits hyperxia-induced cell apoptosis through up-regulating SIRT1 expression in HPAECs -RSB- .
26174951	0	Resveratrol	54,65	SIRT1	0,5	Resveratrol	SIRT1	MESH:C059514	23411	Chemical	Gene	signaling|nmod|START_ENTITY VEGF/VEGFR2|acl|signaling inhibition|nmod|VEGF/VEGFR2 mediated|dobj|inhibition mediated|nsubj|END_ENTITY	SIRT1 mediated inhibition of VEGF/VEGFR2 signaling by Resveratrol and its relevance to choroidal_neovascularization .
26500489	0	Resveratrol	0,11	SIRT1	30,35	Resveratrol	SIRT1	MESH:C059514	23411	Chemical	Gene	START_ENTITY|dep|effects effects|nmod|signaling signaling|compound|END_ENTITY	Resveratrol : brain effects on SIRT1 , GPR50 and photoperiodic signaling .
26505388	0	Resveratrol	0,11	SIRT1	44,49	Resveratrol	SIRT1	MESH:C059514	23411	Chemical	Gene	reverse|nsubj|START_ENTITY reverse|dobj|expression expression|nmod|END_ENTITY	Resveratrol could reverse the expression of SIRT1 and MMP-1 in vitro .
26622348	0	Resveratrol	0,11	SIRT1	88,93	Resveratrol	SIRT1	MESH:C059514	309757(Tax:10116)	Chemical	Gene	relieves|nsubj|START_ENTITY relieves|advcl|activating activating|dobj|END_ENTITY	Resveratrol relieves ischemia-induced oxidative stress in the hippocampus by activating SIRT1 .
26708779	0	Resveratrol	0,11	SIRT1	83,88	Resveratrol	SIRT1	MESH:C059514	93759(Tax:10090)	Chemical	Gene	protects|nsubj|START_ENTITY protects|parataxis|role role|nmod|pathways pathways|compound|END_ENTITY	Resveratrol protects mice from paraquat-induced lung_injury : The important role of SIRT1 and NRF2 antioxidant pathways .
26827941	0	Resveratrol	0,11	SIRT1	185,190	Resveratrol	SIRT1	MESH:C059514	309757(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|signaling signaling|acl|implicated implicated|advcl|ionizing ionizing|dobj|polymerase_1 polymerase_1|amod|premature_ovarian_failure premature_ovarian_failure|nmod|crosstalk crosstalk|nmod|silencing_information_regulator_1 silencing_information_regulator_1|appos|END_ENTITY	Resveratrol inhibits inflammatory signaling implicated in ionizing radiation-induced premature_ovarian_failure through antagonistic crosstalk between silencing_information_regulator_1 -LRB- SIRT1 -RRB- and poly -LRB- ADP-ribose -RRB- _ polymerase_1 -LRB- PARP-1 -RRB- .
26891914	0	Resveratrol	0,11	SIRT1	151,156	Resveratrol	SIRT1	MESH:C059514	23411	Chemical	Gene	augments|amod|START_ENTITY ER|nsubj|augments ER|advcl|downregulating downregulating|dobj|Akt Akt|nmod|independent independent|nmod|END_ENTITY	Resveratrol augments ER stress and the cytotoxic effects of glycolytic inhibition in neuroblastoma by downregulating Akt in a mechanism independent of SIRT1 .
27069532	0	Resveratrol	0,11	SIRT1	99,104	Resveratrol	SIRT1	MESH:C059514	23411	Chemical	Gene	Flux|compound|START_ENTITY Flux|nmod|END_ENTITY	Resveratrol Enhances Autophagic Flux and Promotes Ox-LDL Degradation in HUVECs via Upregulation of SIRT1 .
20806083	0	Resveratrol	0,11	SOD-1	111,116	Resveratrol	SOD-1	MESH:C059514	6647	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|END_ENTITY	Resveratrol protects human lens epithelial cells against H2O2-induced oxidative stress by increasing catalase , SOD-1 , and HO-1 expression .
19285015	0	Resveratrol	0,11	SREBP1	39,45	Resveratrol	SREBP1	MESH:C059514	20787(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Resveratrol inhibits the expression of SREBP1 in cell model of steatosis via Sirt1-FOXO1 signaling pathway .
16150460	0	Resveratrol	0,11	STAT3	110,115	Resveratrol	STAT3	MESH:C059514	6774	Chemical	Gene	expression|amod|START_ENTITY expression|dep|effects effects|nmod|inhibition inhibition|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Resveratrol suppresses IL-6-induced ICAM-1 gene expression in endothelial cells : effects on the inhibition of STAT3 phosphorylation .
24064760	0	Resveratrol	0,11	STAT3	27,32	Resveratrol	STAT3	MESH:C059514	6774	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	Resveratrol suppresses the STAT3 signaling pathway and inhibits proliferation of high glucose-exposed HepG2 cells partly through SIRT1 .
24090995	0	Resveratrol	0,11	STAT3	60,65	Resveratrol	STAT3	MESH:C059514	6774	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|proliferation proliferation|nmod|inhibition inhibition|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Resveratrol suppresses cell proliferation via inhibition of STAT3 phosphorylation and Mcl-1 and cIAP-2 expression in HTLV-1-infected T cells .
26911335	0	Resveratrol	0,11	STAT3	36,41	Resveratrol	STAT3	MESH:C059514	6774	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|activation activation|amod|constitutive constitutive|dep|END_ENTITY	Resveratrol attenuates constitutive STAT3 and STAT5 activation through induction of PTP and SHP-2 tyrosine phosphatases and potentiates sorafenib-induced apoptosis in renal_cell_carcinoma .
24416418	0	Resveratrol	0,11	SirT1	87,92	Resveratrol	SirT1	MESH:C059514	23411	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|cell cell|acl|differentiation differentiation|nmod|stimulation stimulation|nmod|END_ENTITY	Resveratrol induces vascular smooth muscle cell differentiation through stimulation of SirT1 and AMPK .
22539994	0	Resveratrol	0,11	Sirt-1	35,41	Resveratrol	Sirt-1	MESH:C059514	23411	Chemical	Gene	modulation|amod|START_ENTITY modulation|nmod|END_ENTITY	Resveratrol mediated modulation of Sirt-1 / Runx2 promotes osteogenic differentiation of mesenchymal stem cells : potential role of Runx2 deacetylation .
19046449	0	Resveratrol	0,11	Sirt1	95,100	Resveratrol	Sirt1	MESH:C059514	23411	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|nmod|upregulation upregulation|nmod|END_ENTITY	Resveratrol prevents antibody-induced apoptotic death of retinal cells through upregulation of Sirt1 and Ku70 .
22113495	0	Resveratrol	0,11	Sirt1	85,90	Resveratrol	Sirt1	MESH:C059514	23411	Chemical	Gene	improves|nsubj|START_ENTITY improves|dobj|contractility contractility|nmod|trauma-hemorrhage trauma-hemorrhage|nmod|END_ENTITY	Resveratrol improves cardiac contractility following trauma-hemorrhage by modulating Sirt1 .
23337935	0	Resveratrol	0,11	Sirt1	109,114	Resveratrol	Sirt1	MESH:C059514	309757(Tax:10116)	Chemical	Gene	facilitates|nsubj|START_ENTITY facilitates|nmod|activation activation|nmod|END_ENTITY	Resveratrol facilitates pain attenuation in a rat model of neuropathic_pain through the activation of spinal Sirt1 .
23625030	0	Resveratrol	0,11	Sirt1	94,99	Resveratrol	Sirt1	MESH:C059514	93759(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|parataxis|model model|nmod|activation activation|nmod|END_ENTITY	Resveratrol reduces acute_lung_injury in a LPS - induced sepsis_mouse model via activation of Sirt1 .
24073240	0	Resveratrol	0,11	Sirt1	88,93	Resveratrol	Sirt1	MESH:C059514	93759(Tax:10090)	Chemical	Gene	+|compound|START_ENTITY T|nsubj|+ T|advcl|enhancing enhancing|dobj|expression expression|nmod|END_ENTITY	Resveratrol Inhibits CD4 + T cell activation by enhancing the expression and activity of Sirt1 .
25849131	0	Resveratrol	0,11	Sirt1	31,36	Resveratrol	Sirt1	MESH:C059514	309757(Tax:10116)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network .
26499368	0	Resveratrol	0,11	Sirt1	100,105	Resveratrol	Sirt1	MESH:C059514	23411	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|damage damage|nmod|activation activation|appos|END_ENTITY	Resveratrol induces human keratinocyte damage via the activation of class III histone deacetylase , Sirt1 .
25352008	0	Resveratrol	0,11	Sirtuin_1	97,106	Resveratrol	Sirtuin 1	MESH:C059514	309757(Tax:10116)	Chemical	Gene	attenuates|amod|START_ENTITY attenuates|dep|Involvement Involvement|nmod|END_ENTITY	Resveratrol attenuates intermittent hypoxia - induced insulin resistance in rats : Involvement of Sirtuin_1 and the phosphatidylinositol -4,5 __ - bisphosphate 3 - kinase/AKT pathway .
16546976	0	Resveratrol	0,11	Stat3	111,116	Resveratrol	Stat3	MESH:C059514	6774	Chemical	Gene	Src|compound|START_ENTITY signaling|nsubj|Src signaling|dobj|apoptosis apoptosis|nmod|cells cells|acl|containing containing|dobj|protein protein|nummod|END_ENTITY	Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein .
26138072	0	Resveratrol	2,13	Stat3	50,55	Resveratrol	Stat3	MESH:C059514	6774	Chemical	Gene	Serine|compound|START_ENTITY Serine|compound|END_ENTITY	A Resveratrol Analogue Promotes ERKMAPK-Dependent Stat3 Serine and Tyrosine Phosphorylation Alterations and Antitumor Effects In Vitro against Human Tumor Cells .
25961950	0	Resveratrol	30,41	TCF4	0,4	Resveratrol	TCF4	MESH:C059514	6934	Chemical	Gene	Target|nmod|START_ENTITY Target|nsubj|END_ENTITY	TCF4 Is a Molecular Target of Resveratrol in the Prevention of Colorectal_Cancer .
26212201	0	Resveratrol	0,11	TIGAR	21,26	Resveratrol	TIGAR	MESH:C059514	57103	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Resveratrol inhibits TIGAR to promote ROS induced apoptosis and autophagy .
25330860	0	Resveratrol	0,11	TIMP-1	86,92	Resveratrol	TIMP-1	MESH:C059514	116510(Tax:10116)	Chemical	Gene	Attenuates|nsubj|START_ENTITY Attenuates|dobj|Dysfunction Dysfunction|nmod|Regulation Regulation|nmod|Balance Balance|compound|END_ENTITY	Resveratrol Attenuates the Blood-Brain Barrier Dysfunction by Regulation of the MMP-9 / TIMP-1 Balance after Cerebral_Ischemia Reperfusion in Rats .
19142898	0	Resveratrol	0,11	TLR4	67,71	Resveratrol	TLR4	MESH:C059514	21898(Tax:10090)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Resveratrol enhances cell-mediated immune response to DMBA through TLR4 and prevents DMBA induced cutaneous carcinogenesis .
24035785	0	Resveratrol	0,11	TNF-a	21,26	Resveratrol	TNF-a	MESH:C059514	7124	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|amod|END_ENTITY	Resveratrol enhances TNF-a production in human monocytes upon bacterial stimulation .
21410066	0	Resveratrol	0,11	VEGF	21,25	Resveratrol	VEGF	MESH:C059514	7422	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Resveratrol inhibits VEGF expression of human hepatocellular_carcinoma cells through a NF-kappa_B-mediated mechanism .
22451299	0	Resveratrol	0,11	VEGF	136,140	Resveratrol	VEGF	MESH:C059514	7422	Chemical	Gene	exert|nsubj|START_ENTITY exert|nmod|angiogenesis angiogenesis|nmod|secretion secretion|nmod|END_ENTITY	Resveratrol and its synthetic derivatives exert opposite effects on mesothelial cell-dependent angiogenesis via modulating secretion of VEGF and IL-8 / CXCL8 .
22983702	8	Resveratrol	1140,1151	VEGF	1237,1241	Resveratrol	VEGF	MESH:C059514	7422	Chemical	Gene	down-regulated|nsubj|START_ENTITY down-regulated|ccomp|induced induced|nsubj|expressions expressions|nmod|vascular_endothelial_growth_factor vascular_endothelial_growth_factor|appos|END_ENTITY	Resveratrol also down-regulated the increased expressions of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and kinase_insert_domain_receptor -LRB- KDR , or VEGF receptor-2 -RRB- induced by high glucose .
24435444	0	Resveratrol	0,11	VEGF	38,42	Resveratrol	VEGF	MESH:C059514	22339(Tax:10090)	Chemical	Gene	synthesis|compound|START_ENTITY synthesis|compound|END_ENTITY	Resveratrol inhibits BMP-4-stimulated VEGF synthesis in osteoblasts : suppression of S6 kinase .
24901151	0	Resveratrol	0,11	VEGF	21,25	Resveratrol	VEGF	MESH:C059514	7422	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Resveratrol inhibits VEGF gene expression and proliferation of hepatocarcinoma cells .
26136978	0	Resveratrol	0,11	VEGF	37,41	Resveratrol	VEGF	MESH:C059514	22339(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|synthesis synthesis|amod|END_ENTITY	Resveratrol suppresses TGF-b-induced VEGF synthesis in osteoblasts : Inhibition of the p44/p42 MAPKs and SAPK/JNK pathways .
26446654	0	Resveratrol	0,11	Vascular_Endothelial_Growth_Factor	37,71	Resveratrol	Vascular Endothelial Growth Factor	MESH:C059514	7422	Chemical	Gene	START_ENTITY|dobj|Expression Expression|compound|END_ENTITY	Resveratrol Inhibits Hypoxia-Induced Vascular_Endothelial_Growth_Factor Expression and Pathological Neovascularization .
11408617	0	Resveratrol	0,11	activator_protein_1	50,69	Resveratrol	activator protein 1	MESH:C059514	3725	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|compound|END_ENTITY	Resveratrol inhibits phorbol_ester and UV-induced activator_protein_1 activation by interfering with mitogen-activated protein kinase pathways .
10606230	0	Resveratrol	0,11	androgen_receptor	56,73	Resveratrol	androgen receptor	MESH:C059514	367	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Resveratrol inhibits the expression and function of the androgen_receptor in LNCaP prostate_cancer cells .
18202547	0	Resveratrol	0,11	androgen_receptor	31,48	Resveratrol	androgen receptor	MESH:C059514	367	Chemical	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|END_ENTITY	Resveratrol down-regulates the androgen_receptor at the post-translational level in prostate_cancer cells .
25297617	0	Resveratrol	0,11	androgen_receptor	58,75	Resveratrol	androgen receptor	MESH:C059514	367	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|signaling signaling|compound|END_ENTITY	Resveratrol inhibits hypoxia-inducible factor-1a-mediated androgen_receptor signaling and represses_tumor progression in castration-resistant_prostate_cancer .
15849355	0	Resveratrol	0,11	angiotensin_II	21,35	Resveratrol	angiotensin II	MESH:C059514	24179(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	Resveratrol inhibits angiotensin_II - and epidermal_growth_factor-mediated Akt activation : role of Gab1 and Shp2 .
21071431	0	Resveratrol	0,11	angiotensin_II	37,51	Resveratrol	angiotensin II	MESH:C059514	24179(Tax:10116)	Chemical	Gene	blocks|nsubj|START_ENTITY blocks|dobj|activation activation|nmod|cells cells|amod|END_ENTITY	Resveratrol blocks Akt activation in angiotensin_II - or EGF-stimulated vascular smooth muscle cells in a redox-independent manner .
26445217	0	Resveratrol	0,11	apolipoprotein_M	40,56	Resveratrol	apolipoprotein M	MESH:C059514	55937	Chemical	Gene	exerts|nsubj|START_ENTITY exerts|dobj|effect effect|nmod|END_ENTITY	Resveratrol exerts a biphasic effect on apolipoprotein_M .
24726500	0	Resveratrol	0,11	aquaporin_3	106,117	Resveratrol	aquaporin 3	MESH:C059514	360	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Resveratrol inhibition of human keratinocyte proliferation via SIRT1/ARNT/ERK dependent downregulation of aquaporin_3 .
20631324	0	Resveratrol	0,11	aromatic_hydrocarbon_receptor	59,88	Resveratrol	aromatic hydrocarbon receptor	MESH:C059514	196	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|nmod|END_ENTITY	Resveratrol prevents epigenetic silencing of BRCA-1 by the aromatic_hydrocarbon_receptor in human breast_cancer cells .
10496962	0	Resveratrol	0,11	aryl_hydrocarbon_receptor	43,68	Resveratrol	aryl hydrocarbon receptor	MESH:C059514	196	Chemical	Gene	has|nsubj|START_ENTITY has|dobj|activity activity|nmod|END_ENTITY	Resveratrol has antagonist activity on the aryl_hydrocarbon_receptor : implications for prevention of dioxin toxicity .
11780955	0	Resveratrol	0,11	aryl_hydrocarbon_receptor	23,48	Resveratrol	aryl hydrocarbon receptor	MESH:C059514	11622(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Resveratrol , a natural aryl_hydrocarbon_receptor antagonist , protects sperm from DNA damage and apoptosis caused by benzo -LRB- a -RRB- pyrene .
12884409	0	Resveratrol	0,11	aryl_hydrocarbon_receptor	23,48	Resveratrol	aryl hydrocarbon receptor	MESH:C059514	11622(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Resveratrol , a natural aryl_hydrocarbon_receptor antagonist , protects lung from DNA damage and apoptosis caused by benzo -LSB- a -RSB- pyrene .
17872969	0	Resveratrol	0,11	aryl_hydrocarbon_receptor	171,196	Resveratrol	aryl hydrocarbon receptor	MESH:C059514	11622(Tax:10090)	Chemical	Gene	ameliorates|amod|START_ENTITY experimental_allergic_encephalomyelitis|nsubj|ameliorates experimental_allergic_encephalomyelitis|advcl|involving involving|dobj|activation activation|nmod|receptor receptor|compound|END_ENTITY	Resveratrol -LRB- trans-3 ,5,4 ' - trihydroxystilbene -RRB- ameliorates experimental_allergic_encephalomyelitis , primarily via induction of apoptosis in T cells involving activation of aryl_hydrocarbon_receptor and estrogen receptor .
19376845	0	Resveratrol	0,11	aryl_hydrocarbon_receptor	107,132	Resveratrol	aryl hydrocarbon receptor	MESH:C059514	196	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|inhibiting inhibiting|dobj|recruitment recruitment|nmod|complex complex|compound|END_ENTITY	Resveratrol inhibits dioxin-induced expression of human CYP1A1 and CYP1B1 by inhibiting recruitment of the aryl_hydrocarbon_receptor complex and RNA polymerase II to the regulatory regions of the corresponding genes .
9865727	0	Resveratrol	0,11	aryl_hydrocarbon_receptor	86,111	Resveratrol	aryl hydrocarbon receptor	MESH:C059514	196	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|preventing preventing|dobj|activation activation|nmod|END_ENTITY	Resveratrol inhibits transcription of CYP1A1 in vitro by preventing activation of the aryl_hydrocarbon_receptor .
22166204	0	Resveratrol	0,11	atrogin-1	102,111	Resveratrol	atrogin-1	MESH:C059514	114907	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|dobj|expression expression|nmod|END_ENTITY	Resveratrol prevents dexamethasone-induced expression of the muscle_atrophy-related ubiquitin ligases atrogin-1 and MuRF1 in cultured myotubes through a SIRT1-dependent mechanism .
18928588	0	Resveratrol	42,53	bcl-2	86,91	Resveratrol	bcl-2	MESH:C059514	596	Chemical	Gene	Relationship|nmod|START_ENTITY Relationship|nmod|cells cells|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Relationship between apoptotic effect of Resveratrol on KG-1 cells and expression of bcl-2 / bax -RSB- .
20806083	0	Resveratrol	0,11	catalase	101,109	Resveratrol	catalase	MESH:C059514	847	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|SOD-1 SOD-1|compound|END_ENTITY	Resveratrol protects human lens epithelial cells against H2O2-induced oxidative stress by increasing catalase , SOD-1 , and HO-1 expression .
20949323	0	Resveratrol	0,11	cul5	57,61	Resveratrol	cul5	MESH:C059514	8065	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|effect effect|nmod|END_ENTITY	Resveratrol enhances anti-proliferative effect of VACM-1 / cul5 in T47D cancer cells .
10668496	0	Resveratrol	0,11	cyclooxygenase-2	21,37	Resveratrol	cyclooxygenase-2	MESH:C059514	5743	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|transcription transcription|amod|END_ENTITY	Resveratrol inhibits cyclooxygenase-2 transcription in human mammary epithelial cells .
15465334	0	Resveratrol	0,11	cyclooxygenase-2	35,51	Resveratrol	cyclooxygenase-2	MESH:C059514	5743	Chemical	Gene	analogues|amod|START_ENTITY analogues|nmod|inhibitors inhibitors|amod|END_ENTITY	Resveratrol analogues as selective cyclooxygenase-2 inhibitors : synthesis and structure-activity relationship .
15630167	0	Resveratrol	0,11	cyclooxygenase-2	43,59	Resveratrol	cyclooxygenase-2	MESH:C059514	19225(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Resveratrol inhibits phorbol_ester-induced cyclooxygenase-2 expression in mouse skin : MAPKs and AP-1 as potential molecular targets .
23380763	0	Resveratrol	0,11	cyclooxygenase-2	36,52	Resveratrol	cyclooxygenase-2	MESH:C059514	29527(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|amod|END_ENTITY	Resveratrol decreases noise-induced cyclooxygenase-2 expression in the rat cochlea .
9705326	0	Resveratrol	0,11	cyclooxygenase-2	21,37	Resveratrol	cyclooxygenase-2	MESH:C059514	5743	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|transcription transcription|amod|END_ENTITY	Resveratrol inhibits cyclooxygenase-2 transcription and activity in phorbol_ester-treated human mammary epithelial cells .
10448061	0	Resveratrol	0,11	cytochrome_P450_1A1	33,52	Resveratrol	cytochrome P450 1A1	MESH:C059514	1543	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|amod|END_ENTITY	Resveratrol is a selective human cytochrome_P450_1A1 inhibitor .
23800064	0	Resveratrol	0,11	death-associated_protein_kinase_1	38,71	Resveratrol	death-associated protein kinase 1	MESH:C059514	1612	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Resveratrol induces autophagy through death-associated_protein_kinase_1 -LRB- DAPK1 -RRB- in human dermal fibroblasts under normal culture conditions .
10356984	0	Resveratrol	0,11	endothelin-1	107,119	Resveratrol	endothelin-1	MESH:C059514	1906	Chemical	Gene	activity|compound|START_ENTITY activity|dep|reversal reversal|nmod|effects effects|amod|END_ENTITY	Resveratrol inhibits MAPK activity and nuclear translocation in coronary artery smooth muscle : reversal of endothelin-1 stimulatory effects .
15878161	0	Resveratrol	0,11	endothelin-1	44,56	Resveratrol	endothelin-1	MESH:C059514	24323(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Resveratrol inhibits angiotensin_II-induced endothelin-1 gene expression and subsequent proliferation in rat aortic smooth muscle cells .
12594813	0	Resveratrol	0,11	estrogen_receptor	23,40	Resveratrol	estrogen receptor	MESH:C059514	2099	Chemical	Gene	acts|amod|START_ENTITY acts|nmod|END_ENTITY	Resveratrol acts as an estrogen_receptor -LRB- ER -RRB- agonist in breast_cancer cells stably transfected with ER_alpha .
21737614	0	Resveratrol	0,11	estrogen_receptor_alpha	75,98	Resveratrol	estrogen receptor alpha	MESH:C059514	2099	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Resveratrol , through NF-Y/p53/Sin3 / HDAC1 complex phosphorylation , inhibits estrogen_receptor_alpha gene expression via p38MAPK/CK2 signaling in human breast_cancer cells .
24160181	0	Resveratrol	25,36	estrogen_receptor_alpha	81,104	Resveratrol	estrogen receptor alpha	MESH:C059514	2099	Chemical	Gene	antagonist|nmod:poss|START_ENTITY insights|nmod|antagonist insights|nmod|END_ENTITY	Structural insights into Resveratrol 's antagonist and partial agonist actions on estrogen_receptor_alpha .
15882976	0	Resveratrol	0,11	heme_oxygenase-1	24,40	Resveratrol	heme oxygenase-1	MESH:C059514	24451(Tax:10116)	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Resveratrol upregulates heme_oxygenase-1 expression via activation of NF-E2-related_factor_2 in PC12 cells .
22763982	0	Resveratrol	0,11	heme_oxygenase-1	92,108	Resveratrol	heme oxygenase-1	MESH:C059514	15368(Tax:10090)	Chemical	Gene	attenuates|amod|START_ENTITY doxorubicin-induced|nsubj|attenuates doxorubicin-induced|nmod|induction induction|amod|END_ENTITY	Resveratrol attenuates doxorubicin-induced cardiomyocyte apoptosis in lymphoma nude_mice by heme_oxygenase-1 induction .
24451142	0	Resveratrol	0,11	heme_oxygenase-1	113,129	Resveratrol	heme oxygenase-1	MESH:C059514	3162	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|nmod|induction induction|nmod|autophagy autophagy|amod|END_ENTITY	Resveratrol partially prevents rotenone-induced neurotoxicity in dopaminergic SH-SY5Y cells through induction of heme_oxygenase-1 dependent autophagy .
25815690	0	Resveratrol	0,11	heme_oxygenase-1	195,211	Resveratrol	heme oxygenase-1	MESH:C059514	3162	Chemical	Gene	piceatannol|amod|START_ENTITY restores|nsubj|piceatannol restores|dobj|signaling signaling|nmod|nitric_oxide nitric_oxide|nmod|activation activation|nmod|END_ENTITY	Resveratrol analog piceatannol restores the palmitic_acid-induced impairment_of_insulin signaling and production of endothelial nitric_oxide via activation of anti-inflammatory and antioxidative heme_oxygenase-1 in human endothelial cells .
23691207	0	Resveratrol	0,11	heme_oxygenase_1	103,119	Resveratrol	heme oxygenase 1	MESH:C059514	3162	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|END_ENTITY	Resveratrol protects C6 astrocyte cell line against hydrogen_peroxide-induced oxidative stress through heme_oxygenase_1 .
20155626	0	Resveratrol	0,11	iNOS	36,40	Resveratrol	iNOS	MESH:C059514	18126(Tax:10090)	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|expression expression|amod|END_ENTITY	Resveratrol and piceatannol inhibit iNOS expression and NF-kappaB activation in dextran sulfate_sodium-induced mouse colitis .
21810931	0	Resveratrol	0,11	inducible_nitric_oxide_synthase	26,57	Resveratrol	inducible nitric oxide synthase	MESH:C059514	4843	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Resveratrol inhibition of inducible_nitric_oxide_synthase in skeletal muscle involves AMPK but not SIRT1 .
22044919	0	Resveratrol	0,11	inducible_nitric_oxide_synthase	45,76	Resveratrol	inducible nitric oxide synthase	MESH:C059514	4843	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Resveratrol inhibits interleukin_1b-mediated inducible_nitric_oxide_synthase expression in articular chondrocytes by activating SIRT1 and thereby suppressing nuclear factor-kB activity .
21163946	0	Resveratrol	0,11	insulin	43,50	Resveratrol	insulin	MESH:C059514	3630	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|secretion secretion|compound|END_ENTITY	Resveratrol potentiates glucose-stimulated insulin secretion in INS-1E beta-cells and human islets through a SIRT1-dependent mechanism .
25184950	0	Resveratrol	0,11	interleukin-10	38,52	Resveratrol	interleukin-10	MESH:C059514	3586	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Resveratrol induces the expression of interleukin-10 and brain-derived_neurotrophic_factor in BV2 microglia under hypoxia .
11108930	0	Resveratrol	0,11	interleukin-6	21,34	Resveratrol	interleukin-6	MESH:C059514	3569	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Resveratrol inhibits interleukin-6 production in cortical mixed glial cells under hypoxia/hypoglycemia followed by reoxygenation .
19373235	0	Resveratrol	0,11	interleukin-6	46,59	Resveratrol	interleukin-6	MESH:C059514	16193(Tax:10090)	Chemical	Gene	attenuates|amod|START_ENTITY angiotensin|nsubj|attenuates angiotensin|dobj|expression expression|amod|END_ENTITY	Resveratrol attenuates angiotensin II-induced interleukin-6 expression and perivascular fibrosis .
22153697	0	Resveratrol	0,11	low_density_lipoprotein_receptor	57,89	Resveratrol	low density lipoprotein receptor	MESH:C059514	3949	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Resveratrol increases the expression and activity of the low_density_lipoprotein_receptor in hepatocytes by the proteolytic activation of the sterol regulatory element-binding proteins .
19108833	0	Resveratrol	0,11	mTOR	25,29	Resveratrol	mTOR	MESH:C059514	21977(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|signaling signaling|nsubj|END_ENTITY	Resveratrol inhibits the mTOR mitogenic signaling evoked by oxidized LDL in smooth muscle cells .
20851890	0	Resveratrol	0,11	mTOR	21,25	Resveratrol	mTOR	MESH:C059514	21977(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Resveratrol inhibits mTOR signaling by promoting the interaction between mTOR and DEPTOR .
20851890	0	Resveratrol	0,11	mTOR	73,77	Resveratrol	mTOR	MESH:C059514	21977(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|mTOR mTOR|acl|signaling signaling|advcl|promoting promoting|dobj|interaction interaction|nmod|END_ENTITY	Resveratrol inhibits mTOR signaling by promoting the interaction between mTOR and DEPTOR .
21168265	0	Resveratrol	0,11	mTOR	52,56	Resveratrol	mTOR	MESH:C059514	21977(Tax:10090)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|nmod|rapamycin rapamycin|compound|END_ENTITY	Resveratrol enhances the anti-tumor activity of the mTOR inhibitor rapamycin in multiple breast_cancer cell lines mainly by suppressing rapamycin-induced AKT signaling .
21966552	0	Resveratrol	0,11	mTOR	21,25	Resveratrol	mTOR	MESH:C059514	21977(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Resveratrol inhibits mTOR signaling by targeting DEPTOR .
23211629	0	Resveratrol	0,11	mTOR	97,101	Resveratrol	mTOR	MESH:C059514	21977(Tax:10090)	Chemical	Gene	pre-treatment|amod|START_ENTITY reduces|nsubj|pre-treatment reduces|dobj|responses responses|acl|induced induced|nmod|status_epilepticus status_epilepticus|nmod|signaling signaling|compound|END_ENTITY	Resveratrol pre-treatment reduces early inflammatory responses induced by status_epilepticus via mTOR signaling .
26200935	0	Resveratrol	0,11	mTOR	51,55	Resveratrol	mTOR	MESH:C059514	21977(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|treatment treatment|nmod|diseases diseases|nmod|hyperactivation hyperactivation|compound|END_ENTITY	Resveratrol as a novel treatment for diseases with mTOR pathway hyperactivation .
26200935	0	Resveratrol	0,11	mTOR	51,55	Resveratrol	mTOR	MESH:C059514	21977(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|treatment treatment|nmod|diseases diseases|nmod|hyperactivation hyperactivation|compound|END_ENTITY	Resveratrol as a novel treatment for diseases with mTOR pathway hyperactivation .
26902888	0	Resveratrol	0,11	mTOR	53,57	Resveratrol	mTOR	MESH:C059514	21977(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|inhibiting inhibiting|dobj|END_ENTITY	Resveratrol induces autophagy by directly inhibiting mTOR through ATP competition .
17257620	0	Resveratrol	0,11	macrophage_inhibitory_cytokine-1	95,127	Resveratrol	macrophage inhibitory cytokine-1	MESH:C059514	9518	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|induction induction|nmod|END_ENTITY	Resveratrol inhibits pancreatic_cancer cell proliferation through transcriptional induction of macrophage_inhibitory_cytokine-1 .
17988825	0	Resveratrol	0,11	matrix_metalloproteinase-9	58,84	Resveratrol	matrix metalloproteinase-9	MESH:C059514	4318	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|necrosis necrosis|dep|expression expression|amod|END_ENTITY	Resveratrol inhibits tumor necrosis factor-alpha-mediated matrix_metalloproteinase-9 expression and invasion of human hepatocellular_carcinoma cells .
23075401	0	Resveratrol	0,11	matrix_metalloproteinase-9	64,90	Resveratrol	matrix metalloproteinase-9	MESH:C059514	81687(Tax:10116)	Chemical	Gene	mitigates|amod|START_ENTITY mitigates|dep|roles roles|acl|END_ENTITY	Resveratrol mitigates rat retinal ischemic_injury : the roles of matrix_metalloproteinase-9 , inducible nitric_oxide , and heme_oxygenase-1 .
25401496	0	Resveratrol	0,11	matrix_metalloproteinase-9	35,61	Resveratrol	matrix metalloproteinase-9	MESH:C059514	4318	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Resveratrol suppresses TPA-induced matrix_metalloproteinase-9 expression through the inhibition of MAPK pathways in oral_cancer cells .
20622002	0	Resveratrol	0,11	miR-155	36,43	Resveratrol	miR-155	MESH:C059514	406947	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|levels levels|nmod|END_ENTITY	Resveratrol decreases the levels of miR-155 by upregulating miR-663 , a microRNA targeting JunB and JunD .
26434860	0	Resveratrol	48,59	miR_15a	63,70	Resveratrol	miR 15a	MESH:C059514	406948	Chemical	Gene	START_ENTITY|nmod|Expression Expression|amod|END_ENTITY	Time - and Concentration - Dependent Effects of Resveratrol on miR_15a and miR16-1 Expression and Apoptosis in the CCRF-CEM Acute_Lymphoblastic_Leukemia Cell Line .
17191021	0	Resveratrol	0,11	monocyte_chemotactic_protein-1	64,94	Resveratrol	monocyte chemotactic protein-1	MESH:C059514	6347	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|synthesis synthesis|amod|END_ENTITY	Resveratrol , a polyphenolic_phytostilbene , inhibits endothelial monocyte_chemotactic_protein-1 synthesis and secretion .
20050970	0	Resveratrol	0,11	monocyte_chemotactic_protein-1	39,69	Resveratrol	monocyte chemotactic protein-1	MESH:C059514	24770(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|amod|END_ENTITY	Resveratrol reduces glutamate-mediated monocyte_chemotactic_protein-1 expression via inhibition of extracellular_signal-regulated_kinase 1/2 pathway in rat hippocampal slice cultures .
22213337	0	Resveratrol	0,11	mucin	21,26	Resveratrol	mucin	MESH:C059514	100508689	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Resveratrol inhibits mucin gene expression , production and secretion from airway epithelial cells .
17844991	0	Resveratrol	0,11	myeloperoxidase	55,70	Resveratrol	myeloperoxidase	MESH:C059514	100070920(Tax:9796)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	Resveratrol inhibits the activity of equine neutrophil myeloperoxidase by a direct interaction with the enzyme .
15228220	0	Resveratrol	0,11	ornithine_decarboxylase	51,74	Resveratrol	ornithine decarboxylase	MESH:C059514	18263(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Resveratrol inhibits N-nitrosodiethylamine-induced ornithine_decarboxylase and cyclooxygenase in mice .
11745454	0	Resveratrol	0,11	p53	64,67	Resveratrol	p53	MESH:C059514	7157	Chemical	Gene	induces|nsubj|START_ENTITY induces|dep|colon_tumor colon_tumor|nmod|END_ENTITY	Resveratrol induces colon_tumor cell apoptosis independently of p53 and precede by epithelial differentiation , mitochondrial proliferation and membrane potential collapse .
11895857	0	Resveratrol	0,11	p53	131,134	Resveratrol	p53	MESH:C059514	7157	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|advcl|increasing increasing|dobj|expression expression|nmod|END_ENTITY	Resveratrol enhances the expression of non-steroidal anti-inflammatory drug-activated gene -LRB- NAG-1 -RRB- by increasing the expression of p53 .
12131363	0	Resveratrol	0,11	p53	46,49	Resveratrol	p53	MESH:C059514	7157	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Resveratrol induced serine phosphorylation of p53 causes apoptosis in a mutant p53 prostate_cancer cell line .
12131363	0	Resveratrol	0,11	p53	79,82	Resveratrol	p53	MESH:C059514	7157	Chemical	Gene	phosphorylation|amod|START_ENTITY causes|nsubj|phosphorylation causes|dobj|apoptosis apoptosis|nmod|line line|compound|END_ENTITY	Resveratrol induced serine phosphorylation of p53 causes apoptosis in a mutant p53 prostate_cancer cell line .
12644594	0	Resveratrol	0,11	p53	77,80	Resveratrol	p53	MESH:C059514	7157	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Resveratrol increases serine15-phosphorylated but transcriptionally impaired p53 and induces a reversible DNA replication block in serum-activated vascular smooth muscle cells .
19810103	0	Resveratrol	0,11	p53	21,24	Resveratrol	p53	MESH:C059514	7157	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|acetylation acetylation|compound|END_ENTITY	Resveratrol enhances p53 acetylation and apoptosis in prostate_cancer by inhibiting MTA1/NuRD complex .
20504360	0	Resveratrol	0,11	p53	146,149	Resveratrol	p53	MESH:C059514	7157	Chemical	Gene	suppresses|nummod|START_ENTITY IGF-1|nmod:npmod|suppresses induced|dep|IGF-1 Wnt|dep|induced Wnt|nmod|END_ENTITY	Resveratrol suppresses IGF-1 induced human colon_cancer cell proliferation and elevates apoptosis via suppression of IGF-1R / Wnt and activation of p53 signaling pathways .
20797428	0	Resveratrol	0,11	p53	20,23	Resveratrol	p53	MESH:C059514	7157	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Resveratrol induces p53 and suppresses myocardin-mediated vascular smooth muscle cell differentiation .
21278141	0	Resveratrol	0,11	p53	115,118	Resveratrol	p53	MESH:C059514	22060(Tax:10090)	Chemical	Gene	attenuates|amod|START_ENTITY doxorubicin-induced|nsubj|attenuates doxorubicin-induced|nmod|deacetylation deacetylation|nmod|END_ENTITY	Resveratrol attenuates doxorubicin-induced cardiomyocyte apoptosis in mice through SIRT1-mediated deacetylation of p53 .
23651583	0	Resveratrol	0,11	p53	67,70	Resveratrol	p53	MESH:C059514	7157	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|degradation degradation|nmod|Nanog Nanog|nmod|activation activation|compound|END_ENTITY	Resveratrol promotes proteasome-dependent degradation of Nanog via p53 activation and induces differentiation of glioma stem cells .
23737838	0	Resveratrol	0,11	p53	154,157	Resveratrol	p53	MESH:C059514	7157	Chemical	Gene	Impedes|nsubj|START_ENTITY Impedes|nmod|Activation Activation|compound|END_ENTITY	Resveratrol Impedes the Stemness , Epithelial-Mesenchymal_Transition , and Metabolic Reprogramming of Cancer Stem Cells in Nasopharyngeal_Carcinoma through p53 Activation .
24218232	0	Resveratrol	0,11	p53	108,111	Resveratrol	p53	MESH:C059514	301300(Tax:10116)	Chemical	Gene	protects|nsubj|START_ENTITY protects|parataxis|effect effect|nmod|localization localization|compound|END_ENTITY	Resveratrol protects DAergic PC12 cells from high glucose-induced oxidative stress and apoptosis : effect on p53 and GRP75 localization .
24239893	0	Resveratrol	0,11	p53	95,98	Resveratrol	p53	MESH:C059514	7157	Chemical	Gene	contributes|nsubj|START_ENTITY contributes|xcomp|chemosensitivity chemosensitivity|nmod|activation activation|nmod|END_ENTITY	Resveratrol contributes to chemosensitivity of malignant_mesothelioma cells with activation of p53 .
24492640	0	Resveratrol	0,11	p53	99,102	Resveratrol	p53	MESH:C059514	301300(Tax:10116)	Chemical	Gene	reverses|nsubj|START_ENTITY reverses|nmod|END_ENTITY	Resveratrol reverses cadmium_chloride-induced testicular_damage and subfertility by downregulating p53 and Bax and upregulating gonadotropins and Bcl-2 gene expression .
25483559	0	Resveratrol	0,11	p53	76,79	Resveratrol	p53	MESH:C059514	301300(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|apoptosis apoptosis|nmod|regulation regulation|nmod|acetylation acetylation|compound|END_ENTITY	Resveratrol inhibits b-amyloid-induced neuronal apoptosis via regulation of p53 acetylation in PC12 cells .
26053177	0	Resveratrol	0,11	p53	116,119	Resveratrol	p53	MESH:C059514	22060(Tax:10090)	Chemical	Gene	SDF-1|compound|START_ENTITY SDF-1|nmod|Cardiac Cardiac|nummod|END_ENTITY	Resveratrol Upregulates Cardiac SDF-1 in Mice with Acute Myocardial_Infarction through the Deacetylation of Cardiac p53 .
26819684	0	Resveratrol	26,37	p53	105,108	Resveratrol	p53	MESH:C059514	301300(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|Injury Injury|nmod|Levels Levels|dep|END_ENTITY	Neuroprotective Effect of Resveratrol on Acute Brain_Ischemia Reperfusion Injury by Measuring Annexin_V , p53 , Bcl-2 Levels in Rats .
17879943	0	Resveratrol	0,11	paraoxonase_1	43,56	Resveratrol	paraoxonase 1	MESH:C059514	5444	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Resveratrol induces catalytic bioscavenger paraoxonase_1 expression and protects against chemical warfare nerve agent toxicity in human cell lines .
17550345	0	Resveratrol	0,11	phosphoinositide_3-kinase	26,51	Resveratrol	phosphoinositide 3-kinase	MESH:C059514	18708(Tax:10090)	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|amod|END_ENTITY	Resveratrol is a class IA phosphoinositide_3-kinase inhibitor .
22574221	0	Resveratrol	0,11	pyruvate_kinase_M2	63,81	Resveratrol	pyruvate kinase M2	MESH:C059514	5315	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|regulating regulating|dobj|END_ENTITY	Resveratrol inhibits cancer cell metabolism by down regulating pyruvate_kinase_M2 via inhibition of mammalian_target_of_rapamycin .
20870710	0	Resveratrol	0,11	sirtuin_1	53,62	Resveratrol	sirtuin 1	MESH:C059514	309757(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|amod|END_ENTITY	Resveratrol reduces lipid peroxidation and increases sirtuin_1 expression in adult animals programmed by neonatal protein restriction .
23844973	0	Resveratrol	0,11	sirtuin_1	15,24	Resveratrol	sirtuin 1	MESH:C059514	23411	Chemical	Gene	START_ENTITY|appos|activator activator|amod|END_ENTITY	Resveratrol , a sirtuin_1 activator , increases IL-6 production by peripheral blood mononuclear cells of patients with knee_osteoarthritis .
24320086	0	Resveratrol	0,11	sirtuin_1	126,135	Resveratrol	sirtuin 1	MESH:C059514	23411	Chemical	Gene	responses|amod|START_ENTITY responses|dep|role role|nmod|pathway pathway|amod|END_ENTITY	Resveratrol suppresses inflammatory responses in endometrial stromal cells derived from endometriosis : a possible role of the sirtuin_1 pathway .
24395567	0	Resveratrol	0,11	sirtuin_1	21,30	Resveratrol	sirtuin 1	MESH:C059514	309757(Tax:10116)	Chemical	Gene	restores|nsubj|START_ENTITY restores|dobj|activity activity|amod|END_ENTITY	Resveratrol restores sirtuin_1 -LRB- SIRT1 -RRB- activity and pyruvate_dehydrogenase_kinase_1 -LRB- PDK1 -RRB- expression after hemorrhagic_injury in a rat model .
25724287	0	Resveratrol	0,11	sirtuin_1	92,101	Resveratrol	sirtuin 1	MESH:C059514	751859(Tax:9823)	Chemical	Gene	improves|nsubj|START_ENTITY improves|dobj|quality quality|nmod|oocytes oocytes|acl|derived derived|nmod|activation activation|amod|END_ENTITY	Resveratrol improves the quality of pig oocytes derived from early antral follicles through sirtuin_1 activation .
26781417	0	Resveratrol	1,12	sirtuin_1	23,32	Resveratrol	sirtuin 1	MESH:C059514	23411	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	-LSB- Resveratrol increases sirtuin_1 expression in peripheral blood mononuclear cells of premature infants and inhibits the oxidative stress induced by hyperoxia in vivo -RSB- .
17138562	0	Resveratrol	0,11	sulfonylurea_receptor	25,46	Resveratrol	sulfonylurea receptor	MESH:C059514	6833	Chemical	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Resveratrol binds to the sulfonylurea_receptor -LRB- SUR -RRB- and induces apoptosis in a SUR subtype-specific manner .
24599349	0	Resveratrol	0,11	tissue_plasminogen_activator	47,75	Resveratrol	tissue plasminogen activator	MESH:C059514	100128998	Chemical	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|END_ENTITY	Resveratrol down-regulates a glutamate-induced tissue_plasminogen_activator via Erk and AMPK/mTOR pathways in rat primary cortical neurons .
18060622	0	Resveratrol	0,11	vascular_endothelial_growth_factor	38,72	Resveratrol	vascular endothelial growth factor	MESH:C059514	7422	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|nmod|END_ENTITY	Resveratrol inhibits the secretion of vascular_endothelial_growth_factor and subsequent proliferation in human leukemia U937 cells .
20606295	0	Resveratrol	0,11	vascular_endothelial_growth_factor	78,112	Resveratrol	vascular endothelial growth factor	MESH:C059514	7422	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Resveratrol inhibits angiogenic response of cultured endothelial F-2 cells to vascular_endothelial_growth_factor , but not to basic_fibroblast_growth_factor .
21783219	0	Resveratrol	0,11	vascular_endothelial_growth_factor	82,116	Resveratrol	vascular endothelial growth factor	MESH:C059514	397157(Tax:9823)	Chemical	Gene	supplementation|amod|START_ENTITY abrogates|nsubj|supplementation abrogates|dobj|effects effects|nmod|END_ENTITY	Resveratrol supplementation abrogates pro-arteriogenic effects of intramyocardial vascular_endothelial_growth_factor in a hypercholesterolemic_swine_model_of_chronic_ischemia .
26758854	0	Resveratrol_Glucuronides	37,61	UDP-Glucuronosyltransferase_1A1	65,96	Resveratrol Glucuronides	UDP-Glucuronosyltransferase 1A1	null	54658	Chemical	Gene	START_ENTITY|nmod|Cells Cells|compound|END_ENTITY	Efflux Transport Characterization of Resveratrol_Glucuronides in UDP-Glucuronosyltransferase_1A1 Transfected Hela Cells : Application of a Cellular Pharmacokinetic Model to Decipher the Contribution of Multidrug_Resistance-Associated_Protein_4 .
18241649	5	Ret	1215,1218	HbH	1225,1228	Ret	HbH	null	3039	Chemical	Gene	START_ENTITY|nmod|patients patients|compound|END_ENTITY	After YSSXG treatment , the levels of Hb , RBC , Ret in 12 HbH patients with gene deletion were elevated -LRB- P < 0.05 , P < 0.01 -RRB- , and the levels of Hb and Ret in 13 HbH patients with gene non-deletion were increased obviously -LRB- P < 0.05 , P < 0.01 -RRB- .
26621242	0	Retinoic_Acid	48,61	CYP26A1	105,112	Retinoic Acid	CYP26A1	MESH:D014212	1592	Chemical	Gene	Cytochrome_P450_26A1|compound|START_ENTITY Cytochrome_P450_26A1|appos|END_ENTITY	Homology Models and Molecular Modeling of Human Retinoic_Acid Metabolizing Enzymes Cytochrome_P450_26A1 -LRB- CYP26A1 -RRB- and P450 26B1 -LRB- CYP26B1 -RRB- .
26621242	0	Retinoic_Acid	48,61	CYP26B1	129,136	Retinoic Acid	CYP26B1	MESH:D014212	56603	Chemical	Gene	Cytochrome_P450_26A1|compound|START_ENTITY Cytochrome_P450_26A1|appos|END_ENTITY	Homology Models and Molecular Modeling of Human Retinoic_Acid Metabolizing Enzymes Cytochrome_P450_26A1 -LRB- CYP26A1 -RRB- and P450 26B1 -LRB- CYP26B1 -RRB- .
11725062	0	Retinoic_Acid	0,13	Epidermal_Growth_Factor_Receptor	24,56	Retinoic Acid	Epidermal Growth Factor Receptor	MESH:D014212	1956	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Retinoic_Acid Modulates Epidermal_Growth_Factor_Receptor Expression in Human Lung Epithelial Cancer Cells .
12106426	0	Retinoic_Acid	43,56	GAP-43	102,108	Retinoic Acid	GAP-43	MESH:D014212	14432(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|Transfer Transfer|nmod|END_ENTITY	Accelerated Differentiation in Response to Retinoic_Acid After Retrovirally Mediated Gene Transfer of GAP-43 into Mouse_Neuroblastoma Cells .
27104669	0	Retinoic_Acid	79,92	NRAS	55,59	Retinoic Acid	NRAS	MESH:D014212	4893	Chemical	Gene	Melanoma|nmod|START_ENTITY Melanoma|compound|END_ENTITY	a-Mangostin , a Natural Agent , Enhances the Response of NRAS Mutant Melanoma to Retinoic_Acid .
26296154	0	Retinoic_Acid	0,13	Opsin	116,121	Retinoic Acid	Opsin	MESH:D014212	368725(Tax:7955)	Chemical	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	Retinoic_Acid Signaling Regulates Differential Expression of the Tandemly-Duplicated Long Wavelength-Sensitive Cone Opsin Genes in Zebrafish .
25343668	0	Retinoic_Acid	0,13	Phosphatase_2A	86,100	Retinoic Acid	Phosphatase 2A	MESH:D014212	5524	Chemical	Gene	Production|compound|START_ENTITY Production|nmod|END_ENTITY	Retinoic_Acid Modulates Interferon-y Production by Hepatic Natural Killer T Cells via Phosphatase_2A and the Extracellular_Signal-Regulated_Kinase Pathway .
26383638	0	Retinoic_Acid	92,105	Phosphoenolpyruvate_Carboxykinase	0,33	Retinoic Acid	Phosphoenolpyruvate Carboxykinase	MESH:D014212	5106	Chemical	Gene	UNASSIGNED|compound|START_ENTITY Target|nmod|UNASSIGNED Target|nsubj|END_ENTITY	Phosphoenolpyruvate_Carboxykinase , a Key Enzyme That Controls Blood Glucose , Is a Target of Retinoic_Acid Receptor-Related Orphan Receptor a. UNASSIGNED : Phosphoenolpyruvate_carboxykinase -LRB- PEPCK -RRB- catalyzes a committed and rate-limiting step in hepatic gluconeogenesis , and its activity is tightly regulated to maintain blood glucose levels within normal limits .
23675020	0	Retinoic_Acid	14,27	RAR	38,41	Retinoic Acid	RAR	MESH:D014212	5914	Chemical	Gene	Receptor|compound|START_ENTITY Receptor|appos|END_ENTITY	Expression of Retinoic_Acid Receptor -LRB- RAR -RRB- a Protein in the Synovial Membrane from Patients with Osteoarthritis and Rheumatoid_Arthritis .
25116705	0	Retinoic_Acid	10,23	RAR	34,37	Retinoic Acid	RAR	MESH:D014212	5914	Chemical	Gene	Receptor|compound|START_ENTITY Receptor|appos|END_ENTITY	A Mollusk Retinoic_Acid Receptor -LRB- RAR -RRB- Ortholog Sheds Light on the Evolution of Ligand Binding .
23358881	0	Retinoic_Acid	49,62	RARB	78,82	Retinoic Acid	RARB	MESH:D014212	5915	Chemical	Gene	Beta|compound|START_ENTITY Beta|appos|END_ENTITY	Prognostic Value of Promoter Hypermethylation of Retinoic_Acid Receptor Beta -LRB- RARB -RRB- and CDKN2 -LRB- p16/MTS1 -RRB- in Prostate_Cancer .
24992177	0	Retinoic_Acid	43,56	RARa	69,73	Retinoic Acid	RARa	MESH:D014212	5914	Chemical	Gene	Receptor-a|compound|START_ENTITY Receptor-a|appos|END_ENTITY	Expression and Subcellular Localization of Retinoic_Acid Receptor-a -LRB- RARa -RRB- in Healthy and Varicocele Human Spermatozoa : Its Possible Regulatory Role in Capacitation and Survival .
25541638	0	Retinoic_Acid	62,75	RXR	0,3	Retinoic Acid	RXR	MESH:D014212	6256	Chemical	Gene	Treatment|compound|START_ENTITY Dissociation|dep|Treatment TR|parataxis|Dissociation TR|dep|Agonist Agonist|compound|END_ENTITY	RXR Agonist Modulates TR : Corepressor Dissociation Upon 9-cis Retinoic_Acid Treatment .
21552804	0	Retinoic_Acid	0,13	granulocyte-colony-stimulating_factor	52,89	Retinoic Acid	granulocyte-colony-stimulating factor	MESH:D014212	1440	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|nmod|END_ENTITY	Retinoic_Acid potently stimulates the production of granulocyte-colony-stimulating_factor in the human monocytic thp-1 cell-line .
18270252	0	Retinoic_acid	0,13	17beta-hydroxysteroid_dehydrogenase_type_2	29,71	Retinoic acid	17beta-hydroxysteroid dehydrogenase type 2	MESH:D014212	3294	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Retinoic_acid -LRB- RA -RRB- regulates 17beta-hydroxysteroid_dehydrogenase_type_2 expression in endometrium : interaction of RA receptors with specificity_protein _ -LRB- SP -RRB- _ 1/SP3 for estradiol metabolism .
3695521	0	Retinoic_acid	0,13	5_alpha-reductase	36,53	Retinoic acid	5 alpha-reductase	MESH:D014212	6715	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	Retinoic_acid -LRB- RA -RRB- : an inhibitor of 5_alpha-reductase in human prostatic_cancer cells .
14560020	0	Retinoic_acid	0,13	ABCA1	45,50	Retinoic acid	ABCA1	MESH:D014212	11303(Tax:10090)	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Retinoic_acid receptor-mediated induction of ABCA1 in macrophages .
1321136	0	Retinoic_acid	0,13	ADH3	96,100	Retinoic acid	ADH3	MESH:D014212	126	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Retinoic_acid activation and thyroid hormone repression of the human alcohol_dehydrogenase gene ADH3 .
17392484	0	Retinoic_acid	0,13	CD1d	24,28	Retinoic acid	CD1d	MESH:D014212	912	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Retinoic_acid regulates CD1d gene expression at the transcriptional level in human and rodent monocytic cells .
12769347	0	Retinoic_acid	0,13	CD38	27,31	Retinoic acid	CD38	MESH:D014212	952	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|expression expression|compound|END_ENTITY	Retinoic_acid induction of CD38 antigen expression on normal and leukemic human myeloid cells : relationship with cell differentiation .
9716600	0	Retinoic_acid	0,13	CD40	23,27	Retinoic acid	CD40	MESH:D014212	958	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	Retinoic_acid inhibits CD40 + interleukin-4-mediated IgE production in vitro .
21653670	0	Retinoic_acid	0,13	CD8	45,48	Retinoic acid	CD8	MESH:D014212	925	Chemical	Gene	START_ENTITY|nsubj|response response|compound|END_ENTITY	Retinoic_acid as a vaccine adjuvant enhances CD8 + T cell response and mucosal protection from viral challenge .
24384390	0	Retinoic_acid	0,13	CYP26	28,33	Retinoic acid	CYP26	MESH:D014212	496314(Tax:8355)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Retinoic_acid regulation by CYP26 in vertebrate lens regeneration .
15006160	0	Retinoic_acid	0,13	CYP4B1	41,47	Retinoic acid	CYP4B1	MESH:D014212	1580	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Retinoic_acid induces corneal epithelial CYP4B1 gene expression and stimulates the synthesis of inflammatory 12-hydroxyeicosanoids .
10938132	0	Retinoic_acid	0,13	Cdx1	28,32	Retinoic acid	Cdx1	MESH:D014212	397695(Tax:8355)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Retinoic_acid regulation of Cdx1 : an indirect mechanism for retinoids and vertebral specification .
14660544	0	Retinoic_acid	0,13	Cdx1	36,40	Retinoic acid	Cdx1	MESH:D014212	12590(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|subset subset|nmod|function function|amod|END_ENTITY	Retinoic_acid regulates a subset of Cdx1 function in vivo .
10816385	0	Retinoic_acid	0,13	EGF-R	26,31	Retinoic acid	EGF-R	MESH:D014212	1956	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|END_ENTITY	Retinoic_acid affects the EGF-R signaling pathway during differentiation induction of human endometrial_adenocarcinoma cells .
10548434	0	Retinoic_acid	0,13	ERK2	40,44	Retinoic acid	ERK2	MESH:D014212	5594	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Retinoic_acid selectively activates the ERK2 but not JNK/SAPK or p38 MAP kinases when inducing myeloid differentiation .
10852350	0	Retinoic_acid	0,13	ERK2	162,166	Retinoic acid	ERK2	MESH:D014212	5594	Chemical	Gene	increases|nsubj|START_ENTITY increases|parataxis|reveals reveals|ccomp|dependent dependent|nmod|END_ENTITY	Retinoic_acid increases amount of phosphorylated_RAF ; ectopic expression of cFMS reveals that retinoic_acid-induced differentiation is more strongly dependent on ERK2 signaling than induced GO_arrest is .
15328022	0	Retinoic_acid	0,13	Fgf10	36,41	Retinoic acid	Fgf10	MESH:D014212	25443(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Retinoic_acid selectively regulates Fgf10 expression and maintains cell identity in the prospective lung field of the developing foregut .
11430695	0	Retinoic_acid	0,13	Fgf4	41,45	Retinoic acid	Fgf4	MESH:D014212	14175(Tax:10090)	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	Retinoic_acid specifically downregulates Fgf4 and inhibits posterior cell proliferation in the developing mouse autopod .
15950488	0	Retinoic_acid	0,13	GDNF	35,39	Retinoic acid	GDNF	MESH:D014212	395569(Tax:9031)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Retinoic_acid negatively regulates GDNF and neurturin receptor expression and responsiveness in embryonic chicken sympathetic neurons .
7588287	0	Retinoic_acid	0,13	GHF-1	61,66	Retinoic acid	GHF-1	MESH:D014212	25517(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Retinoic_acid induces expression of the transcription factor GHF-1 / Pit-1 in pituitary prolactin - and growth_hormone-producing cell lines .
10498757	0	Retinoic_acid	0,13	Gpx2	22,26	Retinoic acid	Gpx2	MESH:D014212	2877	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Retinoic_acid induces Gpx2 gene expression in MCF-7 human breast_cancer cells .
10082656	0	Retinoic_acid	0,13	ICAM-1	44,50	Retinoic acid	ICAM-1	MESH:D014212	3383	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|expression expression|compound|END_ENTITY	Retinoic_acid potentiates TNF-alpha-induced ICAM-1 expression in normal human epidermal keratinocytes .
1646841	0	Retinoic_acid	0,13	IL-1_beta	23,32	Retinoic acid	IL-1 beta	MESH:D014212	3553	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	Retinoic_acid enhances IL-1_beta expression in myeloid_leukemia cells and in human monocytes .
12421932	0	Retinoic_acid	0,13	IL-2	116,120	Retinoic acid	IL-2	MESH:D014212	3558	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|parataxis|involvement involvement|nmod|secretion secretion|compound|END_ENTITY	Retinoic_acid stimulates the cell cycle machinery in normal T cells : involvement of retinoic_acid receptor-mediated IL-2 secretion .
11842302	0	Retinoic_acid	0,13	IL-5	24,28	Retinoic acid	IL-5	MESH:D014212	3567	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|compound|END_ENTITY	Retinoic_acid modulates IL-5 receptor expression and selectively inhibits eosinophil-basophil differentiation of hemopoietic progenitor cells .
8301142	0	Retinoic_acid	0,13	IL-6	41,45	Retinoic acid	IL-6	MESH:D014212	3569	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|production production|compound|END_ENTITY	Retinoic_acid inhibition of IL-1-induced IL-6 production by human lung fibroblasts .
1323613	0	Retinoic_acid	0,13	IL-8	60,64	Retinoic acid	IL-8	MESH:D014212	3576	Chemical	Gene	START_ENTITY|dobj|expression expression|compound|END_ENTITY	Retinoic_acid and phorbol_ester synergistically up-regulate IL-8 expression and specifically modulate protein_kinase_C-epsilon in human skin fibroblasts .
25239070	0	Retinoic_acid	0,13	Lhx8	24,28	Retinoic acid	Lhx8	MESH:D014212	424721(Tax:9031)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Retinoic_acid regulates Lhx8 expression via FGF-8b to the upper jaw development of chick embryo .
17554788	0	Retinoic_acid	0,13	MYCN	40,44	Retinoic acid	MYCN	MESH:D014212	4613	Chemical	Gene	downregulation|amod|START_ENTITY downregulation|nmod|END_ENTITY	Retinoic_acid induced downregulation of MYCN is not mediated through changes in Sp1/Sp3 .
1520304	0	Retinoic_acid	0,13	MyoD1	55,60	Retinoic acid	MyoD1	MESH:D014212	4654	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Retinoic_acid ambivalently regulates the expression of MyoD1 in the myogenic cells in the limb buds of the early developmental stages .
19843154	0	Retinoic_acid	0,13	N-cadherin	55,65	Retinoic acid	N-cadherin	MESH:D014212	1000	Chemical	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	Retinoic_acid is a negative physiological regulator of N-cadherin during early avian heart morphogenesis .
22718360	0	Retinoic_acid	0,13	NF-kB	96,101	Retinoic acid	NF-kB	MESH:D014212	81736(Tax:10116)	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|inhibition inhibition|nmod|END_ENTITY	Retinoic_acid protects cardiomyocytes from high glucose-induced apoptosis through inhibition of NF-kB signaling pathway .
21384111	0	Retinoic_acid	0,13	NFATc1	23,29	Retinoic acid	NFATc1	MESH:D014212	18018(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Retinoic_acid inhibits NFATc1 expression and osteoclast differentiation .
16854989	0	Retinoic_acid	0,13	NRL	77,80	Retinoic acid	NRL	MESH:D014212	4901	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Retinoic_acid regulates the expression of photoreceptor transcription factor NRL .
7881766	0	Retinoic_acid	0,13	PA-FABP	36,43	Retinoic acid	PA-FABP	MESH:D014212	2171	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|gene gene|compound|END_ENTITY	Retinoic_acid induces expression of PA-FABP -LRB- psoriasis-associated fatty_acid-binding protein -RRB- gene in human skin in vivo but not in cultured skin cells .
15095411	0	Retinoic_acid	0,13	PBX1	42,46	Retinoic acid	PBX1	MESH:D014212	18514(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Retinoic_acid regulates the expression of PBX1 , PBX2 , and PBX3 in P19 cells both transcriptionally and post-translationally .
7493637	0	Retinoic_acid	0,13	PKC_alpha	45,54	Retinoic acid	PKC alpha	MESH:D014212	18750(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Retinoic_acid specifically increases nuclear PKC_alpha and stimulates AP-1 transcriptional activity in B16 mouse melanoma cells .
20122913	0	Retinoic_acid	0,13	Pitx2	89,94	Retinoic acid	Pitx2	MESH:D014212	18741(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|signaling signaling|nmod|induction induction|nmod|END_ENTITY	Retinoic_acid signaling in perioptic mesenchyme represses Wnt signaling via induction of Pitx2 and Dkk2 .
23587524	0	Retinoic_acid	0,13	Pyk2	66,70	Retinoic acid	Pyk2	MESH:D014212	2185	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Retinoic_acid induces adhesion and migration in NB4 cells through Pyk2 signaling .
7958449	0	Retinoic_acid	0,13	RAR_beta	31,39	Retinoic acid	RAR beta	MESH:D014212	218772(Tax:10090)	Chemical	Gene	beta|amod|START_ENTITY beta|appos|END_ENTITY	Retinoic_acid receptor beta 2 -LRB- RAR_beta 2 -RRB- null mutant mice appear normal .
9387266	0	Retinoic_acid	1,14	RAR_beta	38,46	Retinoic acid	RAR beta	MESH:D014212	218772(Tax:10090)	Chemical	Gene	beta|compound|START_ENTITY beta|appos|END_ENTITY	-LSB- Retinoic_acid nuclear receptor beta -LRB- RAR_beta -RRB- inhibits breast_carcinoma growth -RSB- .
21523764	0	Retinoic_acid	0,13	REST	22,26	Retinoic acid	REST	MESH:D014212	5978	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|degradation degradation|amod|END_ENTITY	Retinoic_acid induces REST degradation and neuronal differentiation by modulating the expression of SCF -LRB- b-TRCP -RRB- in neuroblastoma cells .
24798975	0	Retinoic_acid	0,13	RORalpha	47,55	Retinoic acid	RORalpha	MESH:D014212	6095	Chemical	Gene	alpha|amod|START_ENTITY alpha|appos|END_ENTITY	Retinoic_acid receptor-related receptor alpha -LRB- RORalpha -RRB- is a prognostic marker for hepatocellular_carcinoma .
18212744	0	Retinoic_acid	0,13	Rae1	28,32	Retinoic acid	Rae1	MESH:D014212	8480	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	Retinoic_acid downregulates Rae1 leading to APC -LRB- Cdh1 -RRB- activation and neuroblastoma SH-SY5Y differentiation .
15739227	0	Retinoic_acid	0,13	Raldh2	27,33	Retinoic acid	Raldh2	MESH:D014212	19378(Tax:10090)	Chemical	Gene	START_ENTITY|acl|generated generated|nmod|END_ENTITY	Retinoic_acid generated by Raldh2 in mesoderm is required for mouse dorsal endodermal pancreas development .
12711858	0	Retinoic_acid	0,13	S100P	66,71	Retinoic acid	S100P	MESH:D014212	6286	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Retinoic_acid increases expression of the calcium-binding protein S100P in human gastric_cancer cells .
15254731	0	Retinoic_acid	0,13	STAT3	59,64	Retinoic acid	STAT3	MESH:D014212	6774	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|compound|END_ENTITY	Retinoic_acid inhibits IL-6-dependent but not constitutive STAT3 activation in Epstein-Barr_virus-immortalized B lymphocytes .
15008977	0	Retinoic_acid	0,13	TNF-alpha	96,105	Retinoic acid	TNF-alpha	MESH:D014212	7124	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Retinoic_acid enhances the gene expression of human polymeric immunoglobulin receptor -LRB- pIgR -RRB- by TNF-alpha .
15602748	0	Retinoic_acid	0,13	TNF-alpha	37,46	Retinoic acid	TNF-alpha	MESH:D014212	24835(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Retinoic_acid inhibits expression of TNF-alpha and iNOS in activated rat microglia .
16386082	0	Retinoic_acid	0,13	VEGF	22,26	Retinoic acid	VEGF	MESH:D014212	7422	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Retinoic_acid induces VEGF gene expression in human retinal pigment epithelial cells -LRB- ARPE-19 -RRB- .
21173077	0	Retinoic_acid	0,13	VEGF	29,33	Retinoic acid	VEGF	MESH:D014212	7422	Chemical	Gene	stimulation|amod|START_ENTITY stimulation|nmod|secretion secretion|compound|END_ENTITY	Retinoic_acid stimulation of VEGF secretion from human endometrial stromal cells is mediated by production of reactive oxygen species .
9285932	0	Retinoic_acid	0,13	VIP	32,35	Retinoic acid	VIP	MESH:D014212	7432	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Retinoic_acid regulation of the VIP and PACAP autocrine ligand and receptor system in human neuroblastoma cell lines .
25677622	0	Retinoic_acid	0,13	Whsc1	49,54	Retinoic acid	Whsc1	MESH:D014212	107823(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Retinoic_acid inhibits histone methyltransferase Whsc1 during palatogenesis .
1321136	0	Retinoic_acid	0,13	alcohol_dehydrogenase	69,90	Retinoic acid	alcohol dehydrogenase	MESH:D014212	10327	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|ADH3 ADH3|amod|END_ENTITY	Retinoic_acid activation and thyroid hormone repression of the human alcohol_dehydrogenase gene ADH3 .
1996113	0	Retinoic_acid	0,13	alcohol_dehydrogenase	44,65	Retinoic acid	alcohol dehydrogenase	MESH:D014212	10327	Chemical	Gene	element|amod|START_ENTITY element|nmod|ADH3 ADH3|amod|END_ENTITY	Retinoic_acid response element in the human alcohol_dehydrogenase gene ADH3 : implications for regulation of retinoic_acid synthesis .
25976364	0	Retinoic_acid	0,13	aldh1a2	34,41	Retinoic acid	aldh1a2	MESH:D014212	100709766	Chemical	Gene	homeostasis|amod|START_ENTITY homeostasis|nmod|END_ENTITY	Retinoic_acid homeostasis through aldh1a2 and cyp26a1 mediates meiotic entry in Nile_tilapia -LRB- Oreochromis_niloticus -RRB- .
17943189	0	Retinoic_acid	0,13	aquaporin_3	24,35	Retinoic acid	aquaporin 3	MESH:D014212	360	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Retinoic_acid increases aquaporin_3 expression in normal human skin .
17673467	0	Retinoic_acid	0,13	beta-catenin	23,35	Retinoic acid	beta-catenin	MESH:D014212	30265(Tax:7955)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Retinoic_acid inhibits beta-catenin through suppression of Cox-2 : a role for truncated adenomatous_polyposis_coli .
12429354	0	Retinoic_acid	0,13	beta-lactoglobulin	57,75	Retinoic acid	beta-lactoglobulin	MESH:D014212	280838(Tax:9913)	Chemical	Gene	properties|amod|START_ENTITY properties|nmod|END_ENTITY	Retinoic_acid binding properties of the lipocalin member beta-lactoglobulin studied by circular dichroism , electronic absorption spectroscopy and molecular modeling methods .
26277894	0	Retinoic_acid	0,13	betaglycan	71,81	Retinoic acid	betaglycan	MESH:D014212	7049	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|expression expression|compound|END_ENTITY	Retinoic_acid enhances lactoferrin-induced IgA responses by increasing betaglycan expression .
26277894	0	Retinoic_acid	0,13	betaglycan	71,81	Retinoic acid	betaglycan	MESH:D014212	7049	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|expression expression|compound|END_ENTITY	Retinoic_acid enhances lactoferrin-induced IgA responses by increasing betaglycan expression .
9502786	0	Retinoic_acid	0,13	c-Jun	36,41	Retinoic acid	c-Jun	MESH:D014212	3725	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|induction induction|nmod|protein protein|amod|END_ENTITY	Retinoic_acid inhibits induction of c-Jun protein by ultraviolet radiation that occurs subsequent to activation of mitogen-activated protein kinase pathways in human skin in vivo .
1568207	0	Retinoic_acid	0,13	c-fos	42,47	Retinoic acid	c-fos	MESH:D014212	2353	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Retinoic_acid inhibition of serum-induced c-fos transcription in a fibrosarcoma cell line .
9040537	0	Retinoic_acid	0,13	cellular_retinol_binding_protein_II	24,59	Retinoic acid	cellular retinol binding protein II	MESH:D014212	5948	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|mRNA mRNA|amod|END_ENTITY	Retinoic_acid increases cellular_retinol_binding_protein_II mRNA and retinol uptake in the human intestinal Caco-2 cell line .
12618289	0	Retinoic_acid	0,13	ciliary_neurotrophic_factor	46,73	Retinoic acid	ciliary neurotrophic factor	MESH:D014212	25707(Tax:10116)	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|nmod|END_ENTITY	Retinoic_acid downregulates the expression of ciliary_neurotrophic_factor in rat Schwann cells .
11980849	0	Retinoic_acid	0,13	cone_arrestin	26,39	Retinoic acid	cone arrestin	MESH:D014212	407	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	Retinoic_acid upregulates cone_arrestin expression in retinoblastoma cells through a Cis element in the distal promoter region .
1886422	0	Retinoic_acid	0,13	cytidine_deaminase	41,59	Retinoic acid	cytidine deaminase	MESH:D014212	978	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Retinoic_acid inhibits the expression of cytidine_deaminase linked to the differentiation of the human leukemic cell line HL-60 .
8238530	0	Retinoic_acid	0,13	elastin	24,31	Retinoic acid	elastin	MESH:D014212	25043(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Retinoic_acid increases elastin in neonatal rat lung fibroblast cultures .
11730831	0	Retinoic_acid	0,13	endothelin-1	25,37	Retinoic acid	endothelin-1	MESH:D014212	1906	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Retinoic_acid suppresses endothelin-1 gene expression at the transcription level in endothelial cells .
11050012	0	Retinoic_acid	0,13	erythropoietin	25,39	Retinoic acid	erythropoietin	MESH:D014212	13856(Tax:10090)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|transcription transcription|compound|END_ENTITY	Retinoic_acid stimulates erythropoietin gene transcription in embryonal_carcinoma cells through the direct repeat of a steroid/thyroid hormone receptor response element half-site in the hypoxia-response enhancer .
8050571	0	Retinoic_acid	0,13	erythropoietin	27,41	Retinoic acid	erythropoietin	MESH:D014212	24335(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|production production|compound|END_ENTITY	Retinoic_acid up-regulates erythropoietin production in hepatoma cells and in vitamin_A-depleted rats .
2707148	0	Retinoic_acid	0,13	growth_hormone	37,51	Retinoic acid	growth hormone	MESH:D014212	81668(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|amod|END_ENTITY	Retinoic_acid selectively stimulates growth_hormone secretion and messenger ribonucleic_acid levels in rat pituitary cells .
2716850	0	Retinoic_acid	0,13	growth_hormone	24,38	Retinoic acid	growth hormone	MESH:D014212	81668(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Retinoic_acid regulates growth_hormone gene expression .
9138077	0	Retinoic_acid	0,13	growth_hormone	25,39	Retinoic acid	growth hormone	MESH:D014212	2688	Chemical	Gene	synthesis|amod|START_ENTITY synthesis|compound|END_ENTITY	Retinoic_acid stimulates growth_hormone synthesis in human somatotropic adenoma cells : characterization of its nuclear receptors .
8752109	0	Retinoic_acid	0,13	hydroxyindole-O-methyltransferase	24,57	Retinoic acid	hydroxyindole-O-methyltransferase	MESH:D014212	438	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|activity activity|amod|END_ENTITY	Retinoic_acid increases hydroxyindole-O-methyltransferase activity and mRNA in human Y-79 retinoblastoma cells .
12526099	0	Retinoic_acid	0,13	inducible_nitric_oxide_synthase	23,54	Retinoic acid	inducible nitric oxide synthase	MESH:D014212	4843	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Retinoic_acid inhibits inducible_nitric_oxide_synthase expression in 3T3-L1 adipocytes .
7714081	0	Retinoic_acid	0,13	intercellular_adhesion_molecule-1	22,55	Retinoic acid	intercellular adhesion molecule-1	MESH:D014212	3383	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|hyperexpression hyperexpression|amod|END_ENTITY	Retinoic_acid induces intercellular_adhesion_molecule-1 hyperexpression in human thyroid_carcinoma cell lines .
8704165	0	Retinoic_acid	0,13	interferon_regulatory_factor-1	24,54	Retinoic acid	interferon regulatory factor-1	MESH:D014212	3659	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|amod|END_ENTITY	Retinoic_acid activates interferon_regulatory_factor-1 gene expression in myeloid cells .
9783809	0	Retinoic_acid	0,13	interleukin-1beta	39,56	Retinoic acid	interleukin-1beta	MESH:D014212	3553	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|amod|END_ENTITY	Retinoic_acid differentially regulates interleukin-1beta and interleukin-1 receptor antagonist production by human alveolar macrophages .
18778286	0	Retinoic_acid	0,13	interleukin-2	31,44	Retinoic acid	interleukin-2	MESH:D014212	16183(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|expression expression|compound|END_ENTITY	Retinoic_acid inhibits in vivo interleukin-2 gene expression and T-cell activation in mice .
10785230	0	Retinoic_acid	0,13	interleukin-6	25,38	Retinoic acid	interleukin-6	MESH:D014212	3569	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|production production|amod|END_ENTITY	Retinoic_acid suppresses interleukin-6 production in human endometrial cells .
9610845	0	Retinoic_acid	0,13	interleukin-6	25,38	Retinoic acid	interleukin-6	MESH:D014212	16193(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|synthesis synthesis|amod|END_ENTITY	Retinoic_acid suppresses interleukin-6 synthesis induced by prostaglandins in osteoblasts .
12397370	0	Retinoic_acid	0,13	leukemia_inhibitory_factor	23,49	Retinoic acid	leukemia inhibitory factor	MESH:D014212	60584(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	Retinoic_acid enhances leukemia_inhibitory_factor expression in OLN-93 oligodendrocytes .
14603524	0	Retinoic_acid	0,13	leukemia_inhibitory_factor	23,49	Retinoic acid	leukemia inhibitory factor	MESH:D014212	16878(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Retinoic_acid inhibits leukemia_inhibitory_factor signaling pathways in mouse embryonic_stem cells .
18078838	0	Retinoic_acid	0,13	matrix_Gla_protein	41,59	Retinoic acid	matrix Gla protein	MESH:D014212	4256	Chemical	Gene	regulator|nsubj|START_ENTITY regulator|nmod|expression expression|compound|END_ENTITY	Retinoic_acid is a negative regulator of matrix_Gla_protein gene expression in teleost fish Sparus aurata .
19401466	0	Retinoic_acid	0,13	monoamine_oxidase_B	24,43	Retinoic acid	monoamine oxidase B	MESH:D014212	4129	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|promoter promoter|amod|END_ENTITY	Retinoic_acid activates monoamine_oxidase_B promoter in human neuronal cells .
7843800	0	Retinoic_acid	0,13	mucin	28,33	Retinoic acid	mucin	MESH:D014212	65202(Tax:10116)	Chemical	Gene	modulation|amod|START_ENTITY modulation|nmod|mRNA mRNA|compound|END_ENTITY	Retinoic_acid modulation of mucin mRNA in rat tracheal explants : response to actinomycin_D , cycloheximide , signal transduction effectors and antisense oligodeoxynucleotide .
1325442	0	Retinoic_acid	0,13	nerve_growth_factor_receptor	47,75	Retinoic acid	nerve growth factor receptor	MESH:D014212	24596(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Retinoic_acid regulates both expression of the nerve_growth_factor_receptor and sensitivity to nerve growth factor .
10854907	0	Retinoic_acid	0,13	neuropeptide_Y	35,49	Retinoic acid	neuropeptide Y	MESH:D014212	4852	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Retinoic_acid negatively regulates neuropeptide_Y expression in human neuroblastoma cells .
10772914	0	Retinoic_acid	0,13	nitric_oxide_synthase-2	23,46	Retinoic acid	nitric oxide synthase-2	MESH:D014212	24599(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Retinoic_acid inhibits nitric_oxide_synthase-2 expression through the retinoic_acid_receptor-alpha .
11149424	0	Retinoic_acid	0,13	ornithine_decarboxylase	130,153	Retinoic acid	ornithine decarboxylase	MESH:D014212	18263(Tax:10090)	Chemical	Gene	receptor|nsubj|START_ENTITY receptor|nmod|inhibition inhibition|nmod|activity activity|compound|END_ENTITY	Retinoic_acid -LRB- RA -RRB- receptor transcriptional activation correlates with inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine_decarboxylase -LRB- ODC -RRB- activity by retinoids : a potential role for trans-RA-induced ZBP-89 in ODC inhibition .
8240270	0	Retinoic_acid	0,13	ornithine_decarboxylase	24,47	Retinoic acid	ornithine decarboxylase	MESH:D014212	4953	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Retinoic_acid regulates ornithine_decarboxylase gene expression at the transcriptional level .
11076800	0	Retinoic_acid	0,13	p11	22,25	Retinoic acid	p11	MESH:D014212	6281	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|levels levels|amod|END_ENTITY	Retinoic_acid reduces p11 protein levels in bronchial epithelial cells by a posttranslational mechanism .
1751405	0	Retinoic_acid	0,13	p34cdc2	35,42	Retinoic acid	p34cdc2	MESH:D014212	983	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Retinoic_acid negatively regulates p34cdc2 expression during human neuroblastoma differentiation .
10364268	0	Retinoic_acid	0,13	p53	123,126	Retinoic acid	p53	MESH:D014212	7157	Chemical	Gene	confers|nsubj|START_ENTITY confers|advcl|modulating modulating|dobj|import import|nmod|END_ENTITY	Retinoic_acid confers resistance to p53-dependent apoptosis in SH-SY5Y neuroblastoma cells by modulating nuclear import of p53 .
11420666	0	Retinoic_acid	0,13	p53	108,111	Retinoic acid	p53	MESH:D014212	7157	Chemical	Gene	activates|nsubj|START_ENTITY activates|nmod|stimulation stimulation|nmod|function function|compound|END_ENTITY	Retinoic_acid activates p53 in human embryonal_carcinoma through retinoid receptor-dependent stimulation of p53 transactivation function .
11420666	0	Retinoic_acid	0,13	p53	24,27	Retinoic acid	p53	MESH:D014212	7157	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Retinoic_acid activates p53 in human embryonal_carcinoma through retinoid receptor-dependent stimulation of p53 transactivation function .
15374966	0	Retinoic_acid	0,13	p53	42,45	Retinoic acid	p53	MESH:D014212	7157	Chemical	Gene	increases|nsubj|START_ENTITY increases|ccomp|keratinocytes keratinocytes|nsubj|expression expression|nmod|caspases caspases|compound|END_ENTITY	Retinoic_acid increases the expression of p53 and proapoptotic caspases and sensitizes keratinocytes to apoptosis : a possible explanation for tumor preventive action of retinoids .
8476634	0	Retinoic_acid	0,13	p53	40,43	Retinoic acid	p53	MESH:D014212	7157	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Retinoic_acid and calcium regulation of p53 , transforming_growth_factor-beta_1 , and transforming_growth_factor-alpha gene expression and growth in adenovirus 12-SV40-transformed human tracheal gland epithelial cells .
9057134	0	Retinoic_acid	0,13	p53	92,95	Retinoic acid	p53	MESH:D014212	22060(Tax:10090)	Chemical	Gene	induced|nsubj|START_ENTITY induced|nmod|line line|acl|immortalized immortalized|nmod|deficiency deficiency|compound|END_ENTITY	Retinoic_acid induced neural differentiation in a neuroectodermal cell line immortalized by p53 deficiency .
10438723	0	Retinoic_acid	0,13	pRB	42,45	Retinoic acid	pRB	MESH:D014212	5925	Chemical	Gene	START_ENTITY|nsubj|phosphorylation phosphorylation|nmod|END_ENTITY	Retinoic_acid prevents phosphorylation of pRB in normal human B lymphocytes : regulation of cyclin E , cyclin_A , and p21 -LRB- Cip1 -RRB- .
8591987	0	Retinoic_acid	0,13	phenol_sulfotransferase	63,86	Retinoic acid	phenol sulfotransferase	MESH:D014212	282485(Tax:9913)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Retinoic_acid inhibits hydrocortisone-stimulated expression of phenol_sulfotransferase in bovine bronchial epithelial cells .
1315012	0	Retinoic_acid	0,13	phosphoenolpyruvate_carboxykinase	86,119	Retinoic acid	phosphoenolpyruvate carboxykinase	MESH:D014212	5106	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|nmod|gene gene|nmod|END_ENTITY	Retinoic_acid , bound to its nuclear receptor , enhances the expression of the gene for phosphoenolpyruvate_carboxykinase .
12706826	0	Retinoic_acid	0,13	phospholipase_D	57,72	Retinoic acid	phospholipase D	MESH:D014212	2822	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Retinoic_acid specifically activates an oleate-dependent phospholipase_D in the nuclei of LA-N-1 neuroblastoma cells .
9888458	0	Retinoic_acid	0,13	prolactin_receptor	24,42	Retinoic acid	prolactin receptor	MESH:D014212	5618	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|compound|END_ENTITY	Retinoic_acid modulates prolactin_receptor expression and prolactin-induced STAT-5 activation in breast_cancer cells in vitro .
7503983	0	Retinoic_acid	0,13	proteolipid_protein	49,68	Retinoic acid	proteolipid protein	MESH:D014212	5354	Chemical	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|compound|END_ENTITY	Retinoic_acid posttranscriptionally up-regulates proteolipid_protein gene expression in C6 glioma cells .
18992716	0	Retinoic_acid	0,13	retinaldehyde_dehydrogenase_1	24,53	Retinoic acid	retinaldehyde dehydrogenase 1	MESH:D014212	216	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	Retinoic_acid modulates retinaldehyde_dehydrogenase_1 gene expression through the induction of GADD153-C/EBPbeta interaction .
10772914	0	Retinoic_acid	0,13	retinoic_acid_receptor-alpha	70,98	Retinoic acid	retinoic acid receptor-alpha	MESH:D014212	24705(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Retinoic_acid inhibits nitric_oxide_synthase-2 expression through the retinoic_acid_receptor-alpha .
10611294	0	Retinoic_acid	0,13	retinoic_acid_receptor_alpha	58,86	Retinoic acid	retinoic acid receptor alpha	MESH:D014212	5914	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|degradation degradation|nmod|END_ENTITY	Retinoic_acid induces proteasome-dependent degradation of retinoic_acid_receptor_alpha -LRB- RARalpha -RRB- and oncogenic RARalpha fusion proteins .
10941258	0	Retinoic_acid	0,13	retinoic_acid_receptor_alpha	122,150	Retinoic acid	retinoic acid receptor alpha	MESH:D014212	19401(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|degradation degradation|nmod|protein protein|acl|encoded encoded|nmod|gene gene|acl|fused fused|nmod|gene gene|compound|END_ENTITY	Retinoic_acid induces the degradation of the leukemogenic protein encoded by the promyelocytic_leukemia gene fused to the retinoic_acid_receptor_alpha gene .
15520197	0	Retinoic_acid	0,13	retinoic_acid_receptor_alpha	88,116	Retinoic acid	retinoic acid receptor alpha	MESH:D014212	5914	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|inhibiting inhibiting|dobj|degradation degradation|nmod|END_ENTITY	Retinoic_acid induces neuroblastoma cell death by inhibiting proteasomal degradation of retinoic_acid_receptor_alpha .
8670216	0	Retinoic_acid	0,13	retinoic_acid_receptor_alpha	65,93	Retinoic acid	retinoic acid receptor alpha	MESH:D014212	24705(Tax:10116)	Chemical	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|nmod|isoforms isoforms|compound|END_ENTITY	Retinoic_acid differentially up-regulates the gene expression of retinoic_acid_receptor_alpha and gamma isoforms in embryo and adult rats .
1330076	0	Retinoic_acid	0,13	thrombomodulin	53,67	Retinoic acid	thrombomodulin	MESH:D014212	7056	Chemical	Gene	counteracts|nsubj|START_ENTITY counteracts|dobj|downregulation downregulation|nmod|END_ENTITY	Retinoic_acid counteracts both the downregulation of thrombomodulin and the induction of tissue factor in cultured human endothelial cells exposed to tumor necrosis factor .
1370608	0	Retinoic_acid	0,13	thrombomodulin	39,53	Retinoic acid	thrombomodulin	MESH:D014212	7056	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|nmod|END_ENTITY	Retinoic_acid stimulates expression of thrombomodulin , a cell surface anticoagulant glycoprotein , on human endothelial cells .
10328956	0	Retinoic_acid	0,13	thrombospondin-1	101,117	Retinoic acid	thrombospondin-1	MESH:D014212	7057	Chemical	Gene	alters|nsubj|START_ENTITY alters|nmod|END_ENTITY	Retinoic_acid alters the mechanism of attachment of malignant_astrocytoma and neuroblastoma cells to thrombospondin-1 .
2059565	0	Retinoic_acid	0,13	thymosin_beta-10	38,54	Retinoic acid	thymosin beta-10	MESH:D014212	50665(Tax:10116)	Chemical	Gene	modulation|compound|START_ENTITY modulation|nmod|expression expression|amod|END_ENTITY	Retinoic_acid and serum modulation of thymosin_beta-10 gene expression in rat neuroblastoma cells .
1846397	0	Retinoic_acid	0,13	thymosin_beta_10	24,40	Retinoic acid	thymosin beta 10	MESH:D014212	50665(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|levels levels|amod|END_ENTITY	Retinoic_acid regulates thymosin_beta_10 levels in rat neuroblastoma cells .
7706255	0	Retinoic_acid	0,13	tissue-type_plasminogen_activator	33,66	Retinoic acid	tissue-type plasminogen activator	MESH:D014212	5327	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|expression expression|amod|END_ENTITY	Retinoic_acid induction of human tissue-type_plasminogen_activator gene expression via a direct repeat element -LRB- DR5 -RRB- located at -7 kilobases .
8832580	0	Retinoic_acid	0,13	tissue_transglutaminase	31,54	Retinoic acid	tissue transglutaminase	MESH:D014212	21817(Tax:10090)	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|promoter promoter|amod|END_ENTITY	Retinoic_acid induction of the tissue_transglutaminase promoter is mediated by a novel response element .
3619945	0	Retinoic_acid	0,13	transferrin	54,65	Retinoic acid	transferrin	MESH:D014212	7018	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Retinoic_acid inhibition of transplasmalemma diferric transferrin reductase .
2519621	0	Retinoic_acid	0,13	transforming_growth_factor-beta_2	22,55	Retinoic acid	transforming growth factor-beta 2	MESH:D014212	21808(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Retinoic_acid induces transforming_growth_factor-beta_2 in cultured keratinocytes and mouse epidermis .
1372988	0	Retinoic_acid	0,13	transforming_growth_factor_beta	21,52	Retinoic acid	transforming growth factor beta	MESH:D014212	7040	Chemical	Gene	mimics|nsubj|START_ENTITY mimics|dobj|END_ENTITY	Retinoic_acid mimics transforming_growth_factor_beta in the regulation of human immunodeficiency virus expression in monocytic cells .
9809989	0	Retinoic_acid	0,13	vasoactive_intestinal_polypeptide_receptor_type-1	51,100	Retinoic acid	vasoactive intestinal polypeptide receptor type-1	MESH:D014212	7433	Chemical	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|nmod|END_ENTITY	Retinoic_acid down-regulates the expression of the vasoactive_intestinal_polypeptide_receptor_type-1 in human breast_carcinoma cell lines .
1708092	0	Retinoic_acid	0,13	zif268	24,30	Retinoic acid	zif268	MESH:D014212	24330(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Retinoic_acid increases zif268 early gene expression in rat preosteoblastic cells .
9048588	0	Retinoic_acids	0,14	17_beta-hydroxysteroid_dehydrogenase_type_1	24,67	Retinoic acids	17 beta-hydroxysteroid dehydrogenase type 1	null	3292	Chemical	Gene	increase|nsubj|START_ENTITY increase|dobj|expression expression|amod|END_ENTITY	Retinoic_acids increase 17_beta-hydroxysteroid_dehydrogenase_type_1 expression in JEG-3 and T47D cells , but the stimulation is potentiated by epidermal_growth_factor , 12-O-tetradecanoylphorbol-13-acetate , and cyclic_adenosine_3 ' ,5 ' - monophosphate only in JEG-3 cells .
9070291	0	Retinoic_acids	0,14	NOR-1	39,44	Retinoic acids	NOR-1	null	8013	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	Retinoic_acids differentially regulate NOR-1 and its closely related orphan nuclear receptor genes in breast_cancer cell line MCF-7 .
16757381	0	Retinoic_acids	0,14	pyruvate_dehydrogenase_kinase_4	87,118	Retinoic acids	pyruvate dehydrogenase kinase 4	null	5166	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|amod|END_ENTITY	Retinoic_acids and trichostatin_A -LRB- TSA -RRB- , a histone deacetylase inhibitor , induce human pyruvate_dehydrogenase_kinase_4 -LRB- PDK4 -RRB- gene expression .
19121872	0	Retinoid	0,8	LRAT	21,25	Retinoid	LRAT	CHEBI:26537	9227	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|appos|END_ENTITY	Retinoid metabolism -LRB- LRAT , REH -RRB- in the liver and plasma retinoids of bullfrog , Rana catesbeiana , in relation to agricultural contamination .
9543171	0	Retinoid	0,8	RXR_alpha	69,78	Retinoid	RXR alpha	CHEBI:26537	6256	Chemical	Gene	expression|amod|START_ENTITY expression|dep|involvement involvement|nmod|END_ENTITY	Retinoid receptors expression in human term placenta : involvement of RXR_alpha in retinoid induced-hCG secretion .
25766503	0	Retinoid	22,30	SMRT	62,66	Retinoid	SMRT	CHEBI:26537	9612	Chemical	Gene	Mediator|nmod|START_ENTITY Mediator|appos|END_ENTITY	Silencing Mediator of Retinoid and Thyroid Hormone Receptors -LRB- SMRT -RRB- regulates glucocorticoid action in adipocytes .
9915825	0	Retinoid	0,8	SMRT	60,64	Retinoid	SMRT	CHEBI:26537	9612	Chemical	Gene	isomers|amod|START_ENTITY differ|nsubj|isomers differ|nmod|ability ability|acl|induce induce|dobj|release release|nmod|corepressor corepressor|amod|END_ENTITY	Retinoid isomers differ in the ability to induce release of SMRT corepressor from retinoic_acid_receptor-alpha .
21707843	0	Retinoid	0,8	retinoid_X_receptor	64,83	Retinoid	retinoid X receptor	CHEBI:26537	6256	Chemical	Gene	receptors|amod|START_ENTITY receptors|dep|END_ENTITY	Retinoid receptors in human esophageal_squamous_cell_carcinoma : retinoid_X_receptor as a potent prognostic factor .
8639713	0	Retinoid	0,8	retinol-binding_protein	20,43	Retinoid	retinol-binding protein	CHEBI:26537	5950	Chemical	Gene	START_ENTITY|xcomp|binding binding|nmod|END_ENTITY	Retinoid binding to retinol-binding_protein and the interference with the interaction with transthyretin .
15310754	0	Retinoid_X	0,10	RXRalpha	27,35	Retinoid X	RXRalpha	null	6256	Chemical	Gene	alpha|compound|START_ENTITY alpha|appos|END_ENTITY	Retinoid_X receptor alpha -LRB- RXRalpha -RRB- helix 12 plays an inhibitory role in the recruitment of the p160 co-activators by unliganded RXRalpha/retinoic _ acid_receptor_alpha heterodimers .
8399088	0	Retinoids	0,9	ApoA-I	20,26	Retinoids	ApoA-I	MESH:D012176	101925978	Chemical	Gene	stimulate|nsubj|START_ENTITY stimulate|dobj|synthesis synthesis|amod|END_ENTITY	Retinoids stimulate ApoA-I synthesis by induction of gene transcription in primary hepatocyte cultures from cynomolgus_monkey -LRB- Macaca_fascicularis -RRB- The influence of different retinoids on apolipoprotein_A-I -LRB- apoA-I -RRB- synthesis and secretion was investigated in primary monolayer cultures of hepatocytes from cynomolgus_monkeys .
14991612	0	Retinoids	0,9	CD95	21,25	Retinoids	CD95	MESH:D012176	14102(Tax:10090)	Chemical	Gene	Fas|compound|START_ENTITY Fas|appos|END_ENTITY	Retinoids induce Fas -LRB- CD95 -RRB- ligand cell surface expression via RARgamma and nur77 in T cells .
8381448	0	Retinoids	0,9	CRABP_II	48,56	Retinoids	CRABP II	MESH:D012176	1382	Chemical	Gene	modulate|nsubj|START_ENTITY modulate|dobj|expression expression|compound|END_ENTITY	Retinoids and state of differentiation modulate CRABP_II gene expression in a skin equivalent .
10334392	0	Retinoids	0,9	IFN-gamma	50,59	Retinoids	IFN-gamma	MESH:D012176	3458	Chemical	Gene	synergize|nsubj|START_ENTITY synergize|xcomp|augment augment|dobj|production production|amod|END_ENTITY	Retinoids synergize with interleukin-2 to augment IFN-gamma and interleukin-12 production by human peripheral blood mononuclear cells .
17164434	0	Retinoids	0,9	MMP-9	17,22	Retinoids	MMP-9	MESH:D012176	81687(Tax:10116)	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|compound|END_ENTITY	Retinoids induce MMP-9 expression through RARalpha during mammary gland remodeling .
11904524	0	Retinoids	0,9	PAI-1	21,26	Retinoids	PAI-1	MESH:D012176	5054	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|compound|END_ENTITY	Retinoids induce the PAI-1 gene expression through tyrosine kinase-dependent pathways in vascular smooth muscle cells .
8661485	0	Retinoids	0,9	PTH	33,36	Retinoids	PTH	MESH:D012176	24694(Tax:10116)	Chemical	Gene	modulate|nsubj|START_ENTITY modulate|dobj|effect effect|nmod|END_ENTITY	Retinoids modulate the effect of PTH and calcitriol on EGF_receptor expression in UMR 106-01 cells .
21519922	0	Retinoids	0,9	Pck1	18,22	Retinoids	Pck1	MESH:D012176	362282(Tax:10116)	Chemical	Gene	induced|nsubj|START_ENTITY induced|dobj|expression expression|amod|END_ENTITY	Retinoids induced Pck1 expression and attenuated insulin-mediated suppression of its expression via activation of retinoic_acid receptor in primary rat hepatocytes .
26921571	0	Retinoids	80,89	Somatostatin	51,63	Retinoids	Somatostatin	MESH:D012176	6750	Chemical	Gene	sulfate|appos|START_ENTITY sulfate|compound|END_ENTITY	Congenital_fibrosarcoma in complete remission with Somatostatin , Bromocriptine , Retinoids , Vitamin_D3 , Vitamin_E , Vitamin_C , Melatonin , Calcium , Chondroitin sulfate associated with low doses of Cyclophosphamide in a 14-year Follow up .
18773928	0	Retinoids	0,9	TGFbeta	19,26	Retinoids	TGFbeta	MESH:D012176	21803(Tax:10090)	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	Retinoids regulate TGFbeta signaling at the level of Smad2 phosphorylation and nuclear accumulation .
2123476	0	Retinoids	0,9	phospholipase_A2	18,34	Retinoids	phospholipase A2	MESH:D012176	151056	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|END_ENTITY	Retinoids inhibit phospholipase_A2 in human synovial fluid and arachidonic_acid release from rat peritoneal macrophages .
11230116	0	Retinoids	0,9	retinoic_acid_receptor_alpha	80,108	Retinoids	retinoic acid receptor alpha	MESH:D012176	19401(Tax:10090)	Chemical	Gene	induce|nsubj|START_ENTITY induce|nmod|cells cells|nmod|activation activation|compound|END_ENTITY	Retinoids induce fibroblast_growth_factor-2 production in endothelial cells via retinoic_acid_receptor_alpha activation and stimulate angiogenesis in vitro and in vivo .
1315216	0	Retinoids	0,9	thymosin_beta_10	63,79	Retinoids	thymosin beta 10	MESH:D012176	50665(Tax:10116)	Chemical	Gene	modulate|nsubj|START_ENTITY modulate|dobj|expression expression|amod|END_ENTITY	Retinoids and a retinoic_acid receptor differentially modulate thymosin_beta_10 gene expression in transfected neuroblastoma cells .
18647223	0	Retinoids	0,9	tissue-type_plasminogen_activator	39,72	Retinoids	tissue-type plasminogen activator	MESH:D012176	5327	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|amod|END_ENTITY	Retinoids and activation of PKC induce tissue-type_plasminogen_activator expression and storage in human astrocytes .
9804359	0	Retinoids	0,9	vascular_endothelial_growth_factor	23,57	Retinoids	vascular endothelial growth factor	MESH:D012176	7422	Chemical	Gene	production|dep|START_ENTITY production|dep|END_ENTITY	Retinoids downregulate vascular_endothelial_growth_factor / vascular_permeability_factor production by normal human keratinocytes .
16510265	0	Retinol	0,7	CREB	56,60	Retinol	CREB	MESH:D014801	1385	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Retinol induces the ERK1/2-dependent phosphorylation of CREB through a pathway involving the generation of reactive oxygen species in cultured Sertoli cells .
19028692	0	Retinol	0,7	DGAT1	26,31	Retinol	DGAT1	MESH:D014801	13350(Tax:10090)	Chemical	Gene	Esterification|compound|START_ENTITY Esterification|nmod|END_ENTITY	Retinol Esterification by DGAT1 Is Essential for Retinoid Homeostasis in Murine Skin .
23936766	0	Retinol	6,13	Insulin	64,71	Retinol	Insulin	MESH:D014801	3630	Chemical	Gene	START_ENTITY|nmod|Resistance Resistance|compound|END_ENTITY	Serum Retinol and Carotenoids in Association with Biomarkers of Insulin Resistance among Premenopausal Women .
18075836	0	Retinol	0,7	MMP-2	35,40	Retinol	MMP-2	MESH:D014801	4313	Chemical	Gene	START_ENTITY|dobj|activity activity|compound|END_ENTITY	Retinol and retinoic_acid increase MMP-2 activity by different pathways in cultured Sertoli cells .
7201552	0	Retinol	26,33	RBP	64,67	Retinol	RBP	MESH:D014801	5950	Chemical	Gene	vitamin_A|appos|START_ENTITY vitamin_A|appos|END_ENTITY	-LSB- Estimation of vitamin_A -LRB- Retinol -RRB- and retinol-binding_protein -LRB- RBP -RRB- in serum of hearing impaired children -LRB- author 's transl -RRB- -RSB- .
8439537	0	Retinol	0,7	RBP	133,136	Retinol	RBP	MESH:D014801	25703(Tax:10116)	Chemical	Gene	cells|amod|START_ENTITY depend|nsubj|cells depend|nmod|END_ENTITY	Retinol uptake from retinol-binding_protein -LRB- RBP -RRB- by liver parenchymal cells in vitro does not specifically depend on its binding to RBP .
8439537	0	Retinol	0,7	RBP	45,48	Retinol	RBP	MESH:D014801	25703(Tax:10116)	Chemical	Gene	cells|amod|START_ENTITY cells|amod|uptake uptake|nmod|retinol-binding_protein retinol-binding_protein|appos|END_ENTITY	Retinol uptake from retinol-binding_protein -LRB- RBP -RRB- by liver parenchymal cells in vitro does not specifically depend on its binding to RBP .
23422196	0	Retinol	0,7	RDH1l	23,28	Retinol	RDH1l	MESH:D014801	322529(Tax:7955)	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	Retinol dehydrogenase , RDH1l , is essential for the heart development and cardiac performance in zebrafish .
26719343	0	Retinol	20,27	RPE65	14,19	Retinol	RPE65	MESH:D014801	6121	Chemical	Gene	Activity|compound|START_ENTITY Activity|compound|END_ENTITY	Inhibition of RPE65 Retinol Isomerase Activity by Inhibitors of Lipid Metabolism .
17219422	0	Retinol	0,7	beta-catenin	18,30	Retinol	beta-catenin	MESH:D014801	1499	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|levels levels|amod|END_ENTITY	Retinol decreases beta-catenin protein levels in retinoic_acid-resistant colon_cancer cell lines .
18440196	0	Retinol	0,7	catalase	35,43	Retinol	catalase	MESH:D014801	847	Chemical	Gene	modulate|nsubj|START_ENTITY modulate|dobj|activity activity|amod|END_ENTITY	Retinol and retinoic_acid modulate catalase activity in Sertoli cells by distinct and gene expression-independent mechanisms .
18533141	0	Retinol	0,7	catalase	18,26	Retinol	catalase	MESH:D014801	847	Chemical	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	Retinol increases catalase activity and protein content by a reactive species-dependent mechanism in Sertoli cells .
8262951	0	Retinol	0,7	cellular_retinol-binding_protein	17,49	Retinol	cellular retinol-binding protein	MESH:D014801	537379(Tax:9913)	Chemical	Gene	START_ENTITY|acl|bound bound|nmod|END_ENTITY	Retinol bound to cellular_retinol-binding_protein is a substrate for cytosolic retinoic_acid synthesis .
3558401	1	Retinol	116,123	cytoplasmic_retinol-binding_protein	172,207	Retinol	cytoplasmic retinol-binding protein	MESH:D014801	537379(Tax:9913)	Chemical	Gene	transfer|nsubj|START_ENTITY transfer|nmod|END_ENTITY	Retinol transfer from plasma retinol-binding_protein to cytoplasmic_retinol-binding_protein with retinyl-ester formation as the intermediate step .
17918208	0	Retinol	0,7	phosphatidylinositol_3-kinase	18,47	Retinol	phosphatidylinositol 3-kinase	MESH:D014801	5293	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|activity activity|amod|END_ENTITY	Retinol decreases phosphatidylinositol_3-kinase activity in colon_cancer cells .
2739217	0	Retinol	0,7	retinol-binding_protein	55,78	Retinol	retinol-binding protein	MESH:D014801	281444(Tax:9913)	Chemical	Gene	system|amod|START_ENTITY system|nmod|END_ENTITY	Retinol transport system in cattle and purification of retinol-binding_protein from bovine serum .
3558401	1	Retinol	116,123	retinol-binding_protein	145,168	Retinol	retinol-binding protein	MESH:D014801	281444(Tax:9913)	Chemical	Gene	transfer|nsubj|START_ENTITY transfer|nmod|END_ENTITY	Retinol transfer from plasma retinol-binding_protein to cytoplasmic_retinol-binding_protein with retinyl-ester formation as the intermediate step .
8439537	0	Retinol	0,7	retinol-binding_protein	20,43	Retinol	retinol-binding protein	MESH:D014801	25703(Tax:10116)	Chemical	Gene	cells|amod|START_ENTITY cells|amod|uptake uptake|nmod|END_ENTITY	Retinol uptake from retinol-binding_protein -LRB- RBP -RRB- by liver parenchymal cells in vitro does not specifically depend on its binding to RBP .
23651513	0	Retinol_palmitate	0,17	Notch1	92,98	Retinol palmitate	Notch1	MESH:C014794	18128(Tax:10090)	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|nmod|END_ENTITY	Retinol_palmitate prevents ischemia-induced cell changes in hippocampal neurons through the Notch1 signaling pathway in mice .
25040132	0	Retrochiasmatic_Area	40,60	Neurokinin-3_Receptor	0,21	Retrochiasmatic Area	Neurokinin-3 Receptor	null	6870	Chemical	Gene	Activation|nmod|START_ENTITY Activation|compound|END_ENTITY	Neurokinin-3_Receptor Activation in the Retrochiasmatic_Area is Essential for the Full Pre-Ovulatory Luteinising Hormone Surge in Ewes .
26722217	0	Reversine	0,9	Oct4	128,132	Reversine	Oct4	MESH:C484369	282316(Tax:9913)	Chemical	Gene	Increases|nsubj|START_ENTITY Increases|nmod|Activation Activation|nmod|END_ENTITY	Reversine Increases the Plasticity of Long-Term Cryopreserved Fibroblasts to Multipotent Progenitor Cells through Activation of Oct4 .
25172665	0	Rexinoid	0,8	retinoid_X_receptor_alpha	54,79	Rexinoid	retinoid X receptor alpha	null	6256	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Rexinoid inhibits Nrf2-mediated transcription through retinoid_X_receptor_alpha .
25940287	0	Rhein	1,6	SIRT1	34,39	Rhein	SIRT1	MESH:C020491	309757(Tax:10116)	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|nmod|END_ENTITY	-LSB- Rhein promotes the expression of SIRT1 in kidney tissues of type 2 diabetic rat -RSB- .
12632075	0	Rhein	0,5	activator_protein-1	27,46	Rhein	activator protein-1	MESH:C020491	16476(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	Rhein inhibits TPA-induced activator_protein-1 activation and cell transformation by blocking the JNK-dependent pathway .
23711136	0	Rhein	0,5	vascular_cell_adhesion_molecule_1	33,66	Rhein	vascular cell adhesion molecule 1	MESH:C020491	7412	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Rhein inhibits the expression of vascular_cell_adhesion_molecule_1 in human umbilical vein endothelial cells with or without lipopolysaccharide stimulation .
20478352	0	Rheosmin	0,8	iNOS	71,75	Rheosmin	iNOS	MESH:C553178	18126(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Rheosmin , a naturally occurring phenolic compound inhibits LPS-induced iNOS and COX-2 expression in RAW264 .7 cells by blocking NF-kappaB activation pathway .
18524772	0	RhoA-GDP	0,8	RhoB	19,23	RhoA-GDP	RhoB	null	388	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|stability stability|compound|END_ENTITY	RhoA-GDP regulates RhoB protein stability .
19402665	0	Rhodamine	0,9	P-glycoprotein	24,38	Rhodamine	P-glycoprotein	null	5243	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Rhodamine inhibitors of P-glycoprotein : an amide/thioamide `` switch '' for ATPase activity .
15961311	0	Rhodanine	0,9	JSP-1	39,44	Rhodanine	JSP-1	MESH:D012236	56940	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Rhodanine derivatives as inhibitors of JSP-1 .
18304812	0	Rhodanine	0,9	PDE4	45,49	Rhodanine	PDE4	MESH:D012236	5141	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Rhodanine derivatives as novel inhibitors of PDE4 .
22940448	0	Rhododendric_acid_A	0,19	PTP1B	39,44	Rhododendric acid A	PTP1B	MESH:C577885	5770	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Rhododendric_acid_A , a new ursane-type PTP1B inhibitor from the endangered plant Rhododendron brachycarpum G. Don .
15316144	0	Rhodostomin	0,11	fibrinogen	64,74	Rhodostomin	fibrinogen	MESH:C072026	2244	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Rhodostomin , a disintegrin , inhibits adhesion of neutrophils to fibrinogen and attenuates superoxide production .
20422365	0	Rhynchophylline	0,15	NR2B	31,35	Rhynchophylline	NR2B	MESH:C052714	24410(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|expression expression|compound|END_ENTITY	Rhynchophylline down-regulates NR2B expression in cortex and hippocampal CA1 area of amphetamine-induced conditioned place preference rat .
12390318	0	Ribavirin	0,9	CD40L	63,68	Ribavirin	CD40L	MESH:D012254	959	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Ribavirin increases mitogen - and antigen-induced expression of CD40L on CD4 + T cells in vivo .
22848715	0	Ribavirin	0,9	Th1	59,62	Ribavirin	Th1	MESH:D012254	51497	Chemical	Gene	exerts|nsubj|START_ENTITY exerts|nmod|functions functions|nmod|END_ENTITY	Ribavirin exerts differential effects on functions of Cd4 + Th1 , Th2 , and regulatory T cell clones in hepatitis_C .
18706892	0	Ribavirin	0,9	eIF4E	18,23	Ribavirin	eIF4E	MESH:D012254	1977	Chemical	Gene	targets|nsubj|START_ENTITY targets|dobj|survival survival|amod|END_ENTITY	Ribavirin targets eIF4E dependent Akt survival signaling .
21415224	0	Ribavirin	0,9	eIF4E	61,66	Ribavirin	eIF4E	MESH:D012254	1977	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|END_ENTITY	Ribavirin treatment effects on breast_cancers overexpressing eIF4E , a biomarker with prognostic specificity for luminal B-type breast_cancer .
18714675	0	Riboflavin	0,10	IL-6	20,24	Riboflavin	IL-6	MESH:D012256	16193(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Riboflavin inhibits IL-6 expression and p38 activation in islet cells .
11396941	0	Riboflavin	0,10	ribA	45,49	Riboflavin	ribA	MESH:D012256	6014	Chemical	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Riboflavin synthesis genes ribE , ribB , ribH , ribA reside in the lux operon of Photobacterium leiognathi .
25330800	0	Ribonucleic_Acid	80,96	KARS	115,119	Ribonucleic Acid	KARS	CHEBI:33697	3735	Chemical	Gene	Synthetase|compound|START_ENTITY Synthetase|appos|END_ENTITY	Congenital Visual_Impairment and Progressive Microcephaly Due to Lysyl-Transfer Ribonucleic_Acid -LRB- RNA -RRB- Synthetase -LRB- KARS -RRB- Mutations : The Expanding Phenotype of Aminoacyl-Transfer RNA Synthetase Mutations in Human Disease .
22547773	0	Ribonucleotide	0,14	RRM1	40,44	Ribonucleotide	RRM1	CHEBI:26561	6240	Chemical	Gene	reductase|amod|START_ENTITY expression|amod|reductase expression|amod|subunit subunit|dep|END_ENTITY	Ribonucleotide reductase large subunit -LRB- RRM1 -RRB- gene expression may predict efficacy of adjuvant mitotane in adrenocortical_cancer .
11741285	0	Ribostamycin	0,12	protein_disulfide_isomerase	48,75	Ribostamycin	protein disulfide isomerase	MESH:D012271	281373(Tax:9913)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	Ribostamycin inhibits the chaperone activity of protein_disulfide_isomerase .
16434099	0	Ricin	0,5	IL-8	14,18	Ricin	IL-8	null	3576	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|secretion secretion|compound|END_ENTITY	Ricin induces IL-8 secretion from human monocyte/macrophages by activating the p38 MAP kinase pathway .
21482695	0	Ridaforolimus	0,13	mTOR	43,47	Ridaforolimus	mTOR	MESH:C515074	21977(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Ridaforolimus -LRB- AP23573 ; MK-8669 -RRB- , a potent mTOR inhibitor , has broad antitumor activity and can be optimally administered using intermittent dosing regimens .
23199482	0	Ridaifen_B	0,10	Grb10_interacting_GYF_protein_2	54,85	Ridaifen B	Grb10 interacting GYF protein 2	MESH:C528171	26058	Chemical	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Ridaifen_B , a tamoxifen derivative , directly binds to Grb10_interacting_GYF_protein_2 .
2148849	0	Ridogrel	0,8	beta-thromboglobulin	100,120	Ridogrel	beta-thromboglobulin	MESH:C060219	5473	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|levels levels|compound|END_ENTITY	Ridogrel , a combined thromboxane synthase inhibitor and receptor blocker , decreases elevated plasma beta-thromboglobulin levels in patients with documented peripheral arterial_disease .
10803787	0	Rifampicin	0,10	CYP2E1	30,36	Rifampicin	CYP2E1	MESH:D012293	13106(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Rifampicin suppresses hepatic CYP2E1 expression and minimizes DNA injury caused by carbon_tetrachloride in perivenular hepatocytes of mice .
16455805	0	Rifampicin	0,10	CYP3A4	24,30	Rifampicin	CYP3A4	MESH:D012293	1576	Chemical	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	Rifampicin induction of CYP3A4 requires pregnane_X_receptor cross talk with hepatocyte_nuclear_factor_4alpha and coactivators , and suppression of small_heterodimer_partner gene expression .
24638036	0	Rifampicin	0,10	GRP78	80,85	Rifampicin	GRP78	MESH:D012293	25617(Tax:10116)	Chemical	Gene	protects|nsubj|START_ENTITY protects|advcl|activating activating|dobj|END_ENTITY	Rifampicin protects PC12 cells from rotenone-induced cytotoxicity by activating GRP78 via PERK-eIF2a-ATF4 pathway .
20054495	0	Rifampicin	0,10	Toll-like_Receptor_2	50,70	Rifampicin	Toll-like Receptor 2	MESH:D012293	24088(Tax:10090)	Chemical	Gene	Inhibits|nsubj|START_ENTITY Inhibits|dobj|Expression Expression|nmod|END_ENTITY	Rifampicin Inhibits the LPS-induced Expression of Toll-like_Receptor_2 via the Suppression of NF-kappaB DNA-binding Activity in RAW 264.7 Cells .
16455805	0	Rifampicin	0,10	pregnane_X_receptor	40,59	Rifampicin	pregnane X receptor	MESH:D012293	8856	Chemical	Gene	induction|compound|START_ENTITY requires|nsubj|induction requires|dobj|talk talk|compound|END_ENTITY	Rifampicin induction of CYP3A4 requires pregnane_X_receptor cross talk with hepatocyte_nuclear_factor_4alpha and coactivators , and suppression of small_heterodimer_partner gene expression .
9517931	0	Rifampin	0,8	CD1b	54,58	Rifampin	CD1b	MESH:D012293	910	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|molecule molecule|amod|END_ENTITY	Rifampin increases cytokine-induced expression of the CD1b molecule in human peripheral blood monocytes .
18332862	0	Rifampin	0,8	MDR1	34,38	Rifampin	MDR1	MESH:D012293	5243	Chemical	Gene	induction|compound|START_ENTITY induction|nmod|expression expression|compound|END_ENTITY	Rifampin and digoxin induction of MDR1 expression and function in human intestinal -LRB- T84 -RRB- epithelial cells .
24002095	0	Rilpivirine	0,11	ABCB1	39,44	Rilpivirine	ABCB1	MESH:C497816	5243	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Rilpivirine inhibits drug transporters ABCB1 , SLC22A1 , and SLC22A2 in vitro .
25629040	0	Riluzole	0,8	BDNF	20,24	Riluzole	BDNF	MESH:D019782	627	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|amod|END_ENTITY	Riluzole stimulates BDNF release from human platelets .
11578843	0	Riluzole	0,8	MPTP	63,67	Riluzole	MPTP	MESH:D019782	19255(Tax:10090)	Chemical	Gene	attenuates|amod|START_ENTITY END_ENTITY|nsubj|attenuates	Riluzole -LRB- 2-amino-6-trifluoromethoxy_benzothiazole -RRB- attenuates MPTP -LRB- 1-methyl-4-phenyl-1 ,2,3,6 - tetrahydropyridine -RRB- neurotoxicity in mice .
11585581	0	Riluzole	0,8	nerve_growth_factor	20,39	Riluzole	nerve growth factor	MESH:D019782	18049(Tax:10090)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|synthesis synthesis|compound|END_ENTITY	Riluzole stimulates nerve_growth_factor , brain-derived_neurotrophic_factor and glial_cell_line-derived_neurotrophic_factor synthesis in cultured mouse astrocytes .
15755787	0	Rimonabant	0,10	CB1	24,27	Rimonabant	CB1	MESH:C089032	1268	Chemical	Gene	START_ENTITY|dep|antagonist antagonist|compound|END_ENTITY	Rimonabant -- a selective CB1 antagonist .
18303686	1	Rimonabant	26,36	CB1	55,58	Rimonabant	CB1	MESH:C089032	1268	Chemical	Gene	START_ENTITY|dep|antagonist antagonist|compound|END_ENTITY	Rimonabant -LRB- Acomplia -RRB- : first CB1 receptor antagonist of the endocannabinoid system -RSB- .
18678611	0	Rimonabant	31,41	CB1	144,147	Rimonabant	CB1	MESH:C089032	1268	Chemical	Gene	Efficacy|compound|START_ENTITY Evaluating|dobj|Efficacy Study|acl|Evaluating SERENADE|dep|Study SERENADE|appos|antagonist antagonist|compound|END_ENTITY	SERENADE : the Study Evaluating Rimonabant Efficacy in Drug-naive Diabetic Patients : effects of monotherapy with rimonabant , the first selective CB1 receptor antagonist , on glycemic control , body weight , and lipid profile in drug-naive type 2 diabetes .
18845788	0	Rimonabant	0,10	CB1	36,39	Rimonabant	CB1	MESH:C089032	12801(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Rimonabant , a selective cannabinoid CB1 receptor antagonist , inhibits atherosclerosis in LDL_receptor-deficient mice .
20399204	0	Rimonabant	0,10	CB1	26,29	Rimonabant	CB1	MESH:C089032	12801(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Rimonabant , a cannabinoid CB1 receptor antagonist , attenuates mechanical allodynia and counteracts oxidative stress and nerve_growth_factor deficit in diabetic mice .
26123153	6	Rimonabant	1108,1118	CB1	1077,1080	Rimonabant	CB1	MESH:C089032	1268	Chemical	Gene	SR141716A|appos|START_ENTITY SR141716A|compound|END_ENTITY	In rodents , treatment with the CB1 inverse agonist SR141716A -LRB- Rimonabant -RRB- , or genetic deletion of CB1 leads to a reduction in voluntary ethanol drinking , ethanol-stimulated dopamine release in the nucleus accumbens , operant self-administration of ethanol , sensitization to the locomotor effects of ethanol , and reinstatement/relapse of ethanol-motivated behavior .
21803969	0	Rimonabant	0,10	cannabinoid_receptor_type_1	14,41	Rimonabant	cannabinoid receptor type 1	MESH:C089032	1268	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Rimonabant , a cannabinoid_receptor_type_1 inverse agonist , inhibits hepatocyte lipogenesis by activating liver_kinase_B1 and AMP-activated protein kinase axis downstream of Ga i/o inhibition .
21803969	0	Rimonabant	0,10	liver_kinase_B1	105,120	Rimonabant	liver kinase B1	MESH:C089032	6794	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Rimonabant , a cannabinoid_receptor_type_1 inverse agonist , inhibits hepatocyte lipogenesis by activating liver_kinase_B1 and AMP-activated protein kinase axis downstream of Ga i/o inhibition .
26481172	0	Risperidone	25,36	KCNH2	66,71	Risperidone	KCNH2	MESH:D018967	3757	Chemical	Gene	START_ENTITY|nmod|Genotype Genotype|compound|END_ENTITY	Differential Response to Risperidone in Schizophrenia Patients by KCNH2 Genotype and Drug Metabolizer Status .
26930529	0	Risperidone	34,45	Prolactin	0,9	Risperidone	Prolactin	MESH:D018967	5617	Chemical	Gene	Treatment|compound|START_ENTITY Levels|dep|Treatment Levels|compound|END_ENTITY	Prolactin Levels During Long-Term Risperidone Treatment in Children and Adolescents : a reanalysis of data .
17174476	0	Risperidone	0,11	Sulfonylurea_Receptor_1	46,69	Risperidone	Sulfonylurea Receptor 1	MESH:D018967	25559(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|levels levels|nmod|END_ENTITY	Risperidone reduces mRNA expression levels of Sulfonylurea_Receptor_1 and TASK1 in PC12 cells .
16936711	0	Risperidone	0,11	p-glycoprotein	37,51	Risperidone	p-glycoprotein	MESH:D018967	5243	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|activity activity|amod|END_ENTITY	Risperidone and paliperidone inhibit p-glycoprotein activity in vitro .
11561931	0	Risperidone	0,11	prolactin	48,57	Risperidone	prolactin	MESH:D018967	5617	Chemical	Gene	added|nsubj|START_ENTITY added|xcomp|clozapine clozapine|nmod|levels levels|compound|END_ENTITY	Risperidone added to clozapine : impact on serum prolactin levels .
19568786	0	Risperidone	65,76	thrombin	3,11	Risperidone	thrombin	MESH:D018967	2147	Chemical	Gene	exert|nsubj|START_ENTITY exert|nmod|END_ENTITY	In thrombin stimulated human platelets Citalopram , Promethazine , Risperidone , and Ziprasidone , but not Diazepam , may exert their pharmacological effects also through intercalation in membrane phospholipids in a receptor-independent manner .
7636736	0	Ritanserin	0,10	5-HT2A	14,20	Ritanserin	5-HT2A	MESH:D016713	29595(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Ritanserin , a 5-HT2A / 2C antagonist , reverses direct dopamine agonist-induced inhibition of midbrain dopamine neurons .
2106150	0	Ritanserin	0,10	5-HT2_receptor	14,28	Ritanserin	5-HT2 receptor	MESH:D016713	3356	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Ritanserin , a 5-HT2_receptor antagonist , does not modify ECT-induced prolactin release .
9195354	0	Ritanserin	0,10	5-HT2_receptor	50,64	Ritanserin	5-HT2 receptor	MESH:D016713	3356	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|effects effects|nmod|DOI DOI|amod|END_ENTITY	Ritanserin attenuates the in vitro effects of the 5-HT2_receptor agonist DOI on skeletal muscles from malignant_hyperthermia-susceptible patients .
18849545	0	Ritonavir	0,9	CD36	20,24	Ritonavir	CD36	MESH:D019438	948	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Ritonavir increases CD36 , ABCA1 and CYP27 expression in THP-1 macrophages .
26348830	0	Ritonavir	63,72	CYP3A4	24,30	Ritonavir	CYP3A4	MESH:D019438	1576	Chemical	Gene	Nanoparticles|compound|START_ENTITY Hepatocytes|nmod|Nanoparticles Inhibition|nmod|Hepatocytes Inhibition|nmod|END_ENTITY	Augmented Inhibition of CYP3A4 in Human Primary Hepatocytes by Ritonavir Solid Drug Nanoparticles .
11719726	0	Ritonavir	0,9	P-glycoprotein	74,88	Ritonavir	P-glycoprotein	MESH:D019438	5243	Chemical	Gene	increases|nsubj|START_ENTITY increases|nmod|evidence evidence|nmod|involvement involvement|amod|END_ENTITY	Ritonavir increases loperamide plasma concentrations without evidence for P-glycoprotein involvement .
11745741	0	Ritonavir	0,9	P-glycoprotein	18,32	Ritonavir	P-glycoprotein	MESH:D019438	5243	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Ritonavir induces P-glycoprotein expression , multidrug_resistance-associated_protein -LRB- MRP1 -RRB- expression , and drug transporter-mediated activity in a human intestinal cell line .
24202050	0	Ritonavir	0,9	VEGF	35,39	Ritonavir	VEGF	MESH:D019438	7422	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Ritonavir inhibits HIF-1a-mediated VEGF expression in retinal pigment epithelial cells in vitro .
24602921	0	Rituximab	0,9	IL-17	20,25	Rituximab	IL-17	CHEBI:64357	3605	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|compound|END_ENTITY	Rituximab modulates IL-17 expression in the salivary glands of patients with primary Sj gren 's syndrome .
24065653	0	Rituximab	0,9	Raf_kinase_inhibitor_protein	42,70	Rituximab	Raf kinase inhibitor protein	CHEBI:64357	29542(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Rituximab regulates the expression of the Raf_kinase_inhibitor_protein via NF-kB in renal tissue of rats with diabetic_nephropathy .
17100983	0	Rivaroxaban	0,11	Factor_Xa	43,52	Rivaroxaban	Factor Xa	MESH:C503223	2159	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Rivaroxaban -LRB- BAY_59-7939 -RRB- -- an oral , direct Factor_Xa inhibitor -- has no clinically relevant interaction with naproxen .
18671707	0	Rivaroxaban	0,11	Factor_Xa	29,38	Rivaroxaban	Factor Xa	MESH:C503223	2159	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Rivaroxaban -- an oral , direct Factor_Xa inhibitor -- has potential for the management of patients with heparin-induced_thrombocytopenia .
19187276	0	Rivaroxaban	0,11	Factor_Xa	31,40	Rivaroxaban	Factor Xa	MESH:C503223	2159	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Rivaroxaban -- an oral , direct Factor_Xa inhibitor : lessons from a broad clinical study programme .
21874549	0	Rivaroxaban	76,87	Factor_Xa	45,54	Rivaroxaban	Factor Xa	MESH:C503223	2159	Chemical	Gene	treatment|appos|START_ENTITY inhibitor|dobj|treatment inhibitor|nsubj|spinal_epidural_haematoma spinal_epidural_haematoma|nmod|END_ENTITY	Spontaneous spinal_epidural_haematoma during Factor_Xa inhibitor treatment -LRB- Rivaroxaban -RRB- .
23391196	0	Rivaroxaban	146,157	Factor_Xa	183,192	Rivaroxaban	Factor Xa	MESH:C503223	2159	Chemical	Gene	Inhibition|compound|START_ENTITY Inhibition|compound|END_ENTITY	Outcomes of discontinuing rivaroxaban compared with warfarin in patients with nonvalvular atrial_fibrillation : analysis from the ROCKET AF trial -LRB- Rivaroxaban Once-Daily , Oral , Direct Factor_Xa Inhibition Compared With Vitamin_K Antagonism for Prevention of Stroke and Embolism Trial in Atrial_Fibrillation -RRB- .
24895454	0	Rivaroxaban	125,136	Factor_Xa	162,171	Rivaroxaban	Factor Xa	MESH:C503223	2159	Chemical	Gene	Efficacy|nmod|START_ENTITY Efficacy|nmod|Inhibition Inhibition|compound|END_ENTITY	Efficacy and safety of rivaroxaban compared with warfarin among elderly patients with nonvalvular atrial_fibrillation in the Rivaroxaban Once Daily , Oral , Direct Factor_Xa Inhibition Compared With Vitamin_K Antagonism for Prevention of Stroke and Embolism Trial in Atrial_Fibrillation -LRB- ROCKET AF -RRB- .
26386791	0	Rivaroxaban	102,113	Factor_Xa	139,148	Rivaroxaban	Factor Xa	MESH:C503223	2159	Chemical	Gene	Inhibition|compound|START_ENTITY Inhibition|compound|END_ENTITY	Efficacy and safety of rivaroxaban in patients with diabetes and nonvalvular atrial_fibrillation : The Rivaroxaban Once-daily , Oral , Direct Factor_Xa Inhibition Compared with Vitamin_K Antagonism for Prevention of Stroke and Embolism Trial in Atrial_Fibrillation -LRB- ROCKET AF Trial -RRB- .
18491993	0	Rivaroxaban	0,11	factor_Xa	28,37	Rivaroxaban	factor Xa	MESH:C503223	2159	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Rivaroxaban , an oral direct factor_Xa inhibitor .
18693206	0	Rivaroxaban	0,11	factor_Xa	41,50	Rivaroxaban	factor Xa	MESH:C503223	2159	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	Rivaroxaban : an oral direct inhibitor of factor_Xa .
19170587	0	Rivaroxaban	0,11	factor_Xa	35,44	Rivaroxaban	factor Xa	MESH:C503223	2159	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Rivaroxaban : a novel , oral , direct factor_Xa inhibitor .
19911670	0	Rivaroxaban	1,12	factor_Xa	55,64	Rivaroxaban	factor Xa	MESH:C503223	2159	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Rivaroxaban -LRB- Xarelto -RRB- : new anticoagulant inhibitor of factor_Xa -RSB- .
19925048	0	Rivaroxaban	0,11	factor_Xa	36,45	Rivaroxaban	factor Xa	MESH:C503223	2159	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Rivaroxaban , the first oral , direct factor_Xa inhibitor .
20139357	0	Rivaroxaban	0,11	factor_Xa	24,33	Rivaroxaban	factor Xa	MESH:C503223	2159	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Rivaroxaban : a new oral factor_Xa inhibitor .
22041827	0	Rivaroxaban	0,11	factor_Xa	20,29	Rivaroxaban	factor Xa	MESH:C503223	2159	Chemical	Gene	START_ENTITY|dep|inhibition inhibition|amod|END_ENTITY	Rivaroxaban : direct factor_Xa inhibition to treat acute deep_vein_thrombosis .
22691670	0	Rivaroxaban	0,11	factor_Xa	29,38	Rivaroxaban	factor Xa	MESH:C503223	2159	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Rivaroxaban , an oral , direct factor_Xa inhibitor : a new option for thromboprophylaxis .
22800431	0	Rivaroxaban	43,54	factor_Xa	22,31	Rivaroxaban	factor Xa	MESH:C503223	2159	Chemical	Gene	effects|appos|START_ENTITY effects|nmod|inhibitor inhibitor|compound|END_ENTITY	The effects of direct factor_Xa inhibitor -LRB- Rivaroxaban -RRB- on the human osteoblastic cell line SaOS2 .
23328267	0	Rivaroxaban	0,11	factor_Xa	21,30	Rivaroxaban	factor Xa	MESH:C503223	2159	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Rivaroxaban : an oral factor_Xa inhibitor .
26077117	0	Rivaroxaban	0,11	factor_Xa	15,24	Rivaroxaban	factor Xa	MESH:C503223	2159	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Rivaroxaban , a factor_Xa inhibitor , improves neovascularization in the ischemic hindlimb of streptozotocin-induced diabetic mice .
11597825	0	Rivastigmine	44,56	Acetylcholinesterase	0,20	Rivastigmine	Acetylcholinesterase	MESH:C072506	11423(Tax:10090)	Chemical	Gene	SDZ_ENA_713|appos|START_ENTITY SDZ_ENA_713|amod|END_ENTITY	Acetylcholinesterase inhibitor SDZ_ENA_713 -LRB- Rivastigmine -RRB- increases brain pyrrolidone_carboxyl peptidase activity .
15383741	0	Rivastigmine	0,12	rEAAC1	66,72	Rivastigmine	rEAAC1	MESH:C072506	25550(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|modulator modulator|nmod|expression expression|amod|END_ENTITY	Rivastigmine as a modulator of the neuronal glutamate transporter rEAAC1 mRNA expression .
10631625	0	Rizatriptan	0,11	5-HT1B	21,27	Rizatriptan	5-HT1B	MESH:C093622	3351	Chemical	Gene	START_ENTITY|appos|agonist agonist|nummod|END_ENTITY	Rizatriptan , a novel 5-HT1B / 1D agonist for migraine : single - and multiple-dose tolerability and pharmacokinetics in healthy subjects .
8310208	0	Ro	74,76	HLA-DPB1	30,38	Ro	HLA-DPB1	null	3115	Chemical	Gene	correlation|nmod|START_ENTITY correlation|nmod|END_ENTITY	No direct correlation between HLA-DPB1 and antibodies against recombinant Ro -LRB- SS-A -RRB- / La -LRB- SS-B -RRB- proteins in systemic_lupus_erythematosus .
8900190	0	Ro-31-8220	42,52	protein_kinase_C	14,30	Ro-31-8220	protein kinase C	MESH:C064758	112476	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	The selective protein_kinase_C inhibitor , Ro-31-8220 , inhibits mitogen-activated_protein_kinase_phosphatase-1 -LRB- MKP-1 -RRB- expression , induces c-Jun expression , and activates Jun_N-terminal_kinase .
9395070	0	Ro31-8220	0,9	protein_kinase_C	19,35	Ro31-8220	protein kinase C	MESH:C064758	112476	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Ro31-8220 inhibits protein_kinase_C to block the phorbol_ester-stimulated release of choline - and ethanolamine-metabolites from C6 glioma cells : p70 S6 kinase and MAPKAP_kinase-1beta do not function downstream of PKC in activating PLD .
15936720	0	Ro5-4864	80,88	cholinephosphotransferase	14,39	Ro5-4864	cholinephosphotransferase	MESH:C028513	56994	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|activity activity|amod|END_ENTITY	Modulation of cholinephosphotransferase activity in breast_cancer cell lines by Ro5-4864 , a peripheral benzodiazepine receptor agonist .
2380287	0	Ro_19-6327	51,61	monoamine_oxidase_B	21,40	Ro 19-6327	monoamine oxidase B	MESH:C059303	4129	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|Determination Determination|nmod|END_ENTITY	Determination of the monoamine_oxidase_B inhibitor Ro_19-6327 in plasma by high-performance liquid chromatography using precolumn derivatization with fluorescamine and fluorescence detection .
11683518	0	Ro_25-1553	60,70	vasoactive_intestinal_polypeptide	18,51	Ro 25-1553	vasoactive intestinal polypeptide	MESH:C089777	7432	Chemical	Gene	agonist|dobj|START_ENTITY agonist|nsubj|effect effect|nmod|END_ENTITY	The effect of the vasoactive_intestinal_polypeptide agonist Ro_25-1553 on induced tone in isolated human airways and pulmonary artery .
12498913	0	Ro_25-6981	52,62	NR2B	18,22	Ro 25-6981	NR2B	MESH:C109643	2904	Chemical	Gene	aggravates|nsubj|START_ENTITY subtype|ccomp|aggravates subtype|nsubj|END_ENTITY	The NMDA receptor NR2B subtype selective antagonist Ro_25-6981 aggravates paroxysmal_dyskinesia in the dt -LRB- sz -RRB- mutant .
15081591	0	Ro_25-6981	29,39	NR2B	43,47	Ro 25-6981	NR2B	MESH:C109643	24410(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Antiparkinsonian activity of Ro_25-6981 , a NR2B subunit specific NMDA receptor antagonist , in animal models of Parkinson 's _ disease .
18809426	0	Ro_25-6981	91,101	NR2B	66,70	Ro 25-6981	NR2B	MESH:C109643	14812(Tax:10090)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	Fear memory impairing effects of systemic treatment with the NMDA NR2B subunit antagonist , Ro_25-6981 , in mice : attenuation with ageing .
9400004	0	Ro_25-6981	0,10	NR2B	99,103	Ro 25-6981	NR2B	MESH:C109643	24410(Tax:10116)	Chemical	Gene	START_ENTITY|appos|blocker blocker|nmod|receptors receptors|acl|containing containing|dobj|subunit subunit|compound|END_ENTITY	Ro_25-6981 , a highly potent and selective blocker of N-methyl-D-aspartate receptors containing the NR2B subunit .
8099689	0	Ro_40-7592	0,10	COMT	14,18	Ro 40-7592	COMT	MESH:C066340	1312	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Ro_40-7592 , a COMT inhibitor , plus levodopa in Parkinson 's _ disease .
7893380	0	Ro_41-1049	39,49	MAO-A	22,27	Ro 41-1049	MAO-A	MESH:C063456	29253(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Effect of a selective MAO-A inhibitor -LRB- Ro_41-1049 -RRB- on striatal L-dopa and dopamine metabolism : an in vivo study .
1282588	0	Ro_42-5892	101,111	renin	84,89	Ro 42-5892	renin	MESH:C065581	5972	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Neurohormonal and blood pressure responses to low-dose infusion of an orally active renin inhibitor , Ro_42-5892 , in salt-replete men .
1720828	0	Ro_42-5892	59,69	renin	14,19	Ro 42-5892	renin	MESH:C065581	5972	Chemical	Gene	Effect|dep|START_ENTITY Effect|nmod|response response|compound|END_ENTITY	Effect of the renin response during renin inhibition : oral Ro_42-5892 in normal humans .
1720828	0	Ro_42-5892	59,69	renin	36,41	Ro 42-5892	renin	MESH:C065581	5972	Chemical	Gene	Effect|dep|START_ENTITY Effect|nmod|response response|nmod|inhibition inhibition|compound|END_ENTITY	Effect of the renin response during renin inhibition : oral Ro_42-5892 in normal humans .
1830563	0	Ro_42-5892	0,10	renin	37,42	Ro 42-5892	renin	MESH:C065581	5972	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|compound|END_ENTITY	Ro_42-5892 is a potent orally active renin inhibitor in primates .
7769797	0	Ro_42-5892	58,68	renin	30,35	Ro 42-5892	renin	MESH:C065581	5972	Chemical	Gene	Responses|appos|START_ENTITY Responses|nmod|inhibitor inhibitor|compound|END_ENTITY	Responses to an orally active renin inhibitor , remikiren -LRB- Ro_42-5892 -RRB- , after controlled salt depletion in humans .
7795817	0	Ro_42-5892	37,47	renin	21,26	Ro 42-5892	renin	MESH:C065581	5972	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|Determination Determination|nmod|END_ENTITY	Determination of the renin inhibitor Ro_42-5892 in human plasma by automated pre-column derivatization , reversed-phase high-performance liquid chromatographic separation and electrochemical detection after post-column irradiation .
8222499	0	Ro_42-5892	49,59	renin	33,38	Ro 42-5892	renin	MESH:C065581	5972	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|Efficacy Efficacy|nmod|END_ENTITY	Efficacy and tolerability of the renin inhibitor Ro_42-5892 in patients with hypertension .
8512659	0	Ro_42-5892	45,55	renin	28,33	Ro 42-5892	renin	MESH:C065581	5972	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Effects of an orally active renin inhibitor , Ro_42-5892 , in patients with essential hypertension .
7632769	0	Ro_43-0463	102,112	monoamine_oxidase-B	71,90	Ro 43-0463	monoamine oxidase-B	MESH:C071353	25750(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Biodistribution and estimated radiation burden for a new 123I-labelled monoamine_oxidase-B inhibitor , Ro_43-0463 : a preliminary report .
1917527	0	Ro_43-0463	85,95	monoamine_oxidase_B	100,119	Ro 43-0463	monoamine oxidase B	MESH:C071353	25750(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Synthesis and biodistribution of 123I_N - -LRB- 2-aminoethyl -RRB- -5 - iodo-2-pyridinecarboxamide -LRB- Ro_43-0463 -RRB- , a monoamine_oxidase_B inhibitor .
7893925	0	Ro_46-6240	98,108	thrombin	47,55	Ro 46-6240	thrombin	MESH:C087198	2147	Chemical	Gene	inhibitor|appos|START_ENTITY Inhibition|nmod|inhibitor Inhibition|appos|END_ENTITY	Inhibition of clot-bound and free -LRB- fluid-phase thrombin -RRB- by a novel synthetic thrombin inhibitor -LRB- Ro_46-6240 -RRB- , recombinant hirudin and heparin in human plasma .
7893925	0	Ro_46-6240	98,108	thrombin	78,86	Ro 46-6240	thrombin	MESH:C087198	2147	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Inhibition of clot-bound and free -LRB- fluid-phase thrombin -RRB- by a novel synthetic thrombin inhibitor -LRB- Ro_46-6240 -RRB- , recombinant hirudin and heparin in human plasma .
1362952	0	Ro_5-3335	63,72	Tat	48,51	Ro 5-3335	Tat	MESH:C072173	24813(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Disposition of the human_immunodeficiency_virus Tat inhibitor , Ro_5-3335 , in rats and dogs .
11810085	0	Ro_61-1790	10,20	endothelin-A_receptor	34,55	Ro 61-1790	endothelin-A receptor	MESH:C109641	443465(Tax:9940)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Effect of Ro_61-1790 , a selective endothelin-A_receptor antagonist , on systemic and uterine hemodynamics and fetal oxygenation in sheep .
18353306	0	Ro_61-8048	50,60	kynurenine_3-hydroxylase	15,39	Ro 61-8048	kynurenine 3-hydroxylase	MESH:C110196	8564	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Effects of the kynurenine_3-hydroxylase inhibitor Ro_61-8048 after intrastriatal injections on the severity of dystonia in the dt sz mutant .
15919100	0	Ro_64-6198	51,61	ORL-1	36,41	Ro 64-6198	ORL-1	MESH:C408068	18389(Tax:10090)	Chemical	Gene	effect|amod|START_ENTITY effect|nmod|END_ENTITY	The effect of a systemically active ORL-1 agonist , Ro_64-6198 , on the acquisition , expression , extinction , and reinstatement of morphine conditioned place preference .
17461893	0	Ro_64-6198	20,30	ORL-1	104,109	Ro 64-6198	ORL-1	MESH:C408068	4987	Chemical	Gene	pharmacology|nmod|START_ENTITY agonist|nsubj|pharmacology agonist|nsubj|receptor receptor|appos|opiate_receptor-like_1 opiate_receptor-like_1|dep|END_ENTITY	The pharmacology of Ro_64-6198 , a systemically active , nonpeptide NOP receptor -LRB- opiate_receptor-like_1 , ORL-1 -RRB- agonist with diverse preclinical therapeutic activity .
25443416	0	Robinin	0,7	TGF-b1	59,65	Robinin	TGF-b1	MESH:C005183	59086(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	Robinin modulates doxorubicin-induced cardiac apoptosis by TGF-b1 signaling pathway in Sprague_Dawley_rats .
25333816	0	Rocaglamide	0,11	tumor_necrosis_factor-related_apoptosis-inducing_ligand	22,77	Rocaglamide	tumor necrosis factor-related apoptosis-inducing ligand	MESH:C107772	22035(Tax:10090)	Chemical	Gene	overcomes|nsubj|START_ENTITY overcomes|dobj|resistance resistance|amod|END_ENTITY	Rocaglamide overcomes tumor_necrosis_factor-related_apoptosis-inducing_ligand resistance in hepatocellular_carcinoma cells by attenuating the inhibition of caspase-8 through cellular FLICE-like-inhibitory protein downregulation .
26950414	0	Rociletinib	0,11	EGFR	32,36	Rociletinib	EGFR	MESH:C000589977	1956	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Rociletinib , a third generation EGFR tyrosine kinase inhibitor : current data and future directions .
15136366	0	Rofecoxib	0,9	C-reactive_protein	37,55	Rofecoxib	C-reactive protein	MESH:C116926	1401	Chemical	Gene	lowers|nsubj|START_ENTITY lowers|dobj|levels levels|amod|END_ENTITY	Rofecoxib , a COX-2 inhibitor , lowers C-reactive_protein and interleukin-6 levels in patients with acute_coronary_syndromes .
11043057	0	Rofecoxib	1,10	COX-2	51,56	Rofecoxib	COX-2	MESH:C116926	4513	Chemical	Gene	START_ENTITY|appos|preparation preparation|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Rofecoxib , a new NSAID preparation with selective COX-2 inhibition -RSB- .
11231941	0	Rofecoxib	0,9	COX-2	13,18	Rofecoxib	COX-2	MESH:C116926	4513	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Rofecoxib , a COX-2 inhibitor , does not inhibit human gastric mucosal prostaglandin production .
11590304	0	Rofecoxib	0,9	COX-2	27,32	Rofecoxib	COX-2	MESH:C116926	4513	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Rofecoxib : a new selective COX-2 inhibitor .
15136366	0	Rofecoxib	0,9	COX-2	13,18	Rofecoxib	COX-2	MESH:C116926	4513	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Rofecoxib , a COX-2 inhibitor , lowers C-reactive_protein and interleukin-6 levels in patients with acute_coronary_syndromes .
17139446	0	Rofecoxib	0,9	COX-2	41,46	Rofecoxib	COX-2	MESH:C116926	19225(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|appos|END_ENTITY	Rofecoxib , a selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitor potentiates the anticonvulsant activity of tiagabine against pentylenetetrazol-induced convulsions in mice .
17670526	0	Rofecoxib	75,84	COX-2	58,63	Rofecoxib	COX-2	MESH:C116926	5743	Chemical	Gene	trial|appos|START_ENTITY trial|nmod|inhibitor inhibitor|compound|END_ENTITY	A randomized , double-blind , placebo-controlled trial of a COX-2 inhibitor -LRB- Rofecoxib -RRB- in patients undergoing coronary artery bypass surgery .
18054463	0	Rofecoxib	0,9	COX-2	41,46	Rofecoxib	COX-2	MESH:C116926	19225(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|appos|END_ENTITY	Rofecoxib , a selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitor increases pentylenetetrazol seizure threshold in mice : possible involvement of adenosinergic mechanism .
21331307	0	Rofecoxib	27,36	COX-2	0,5	Rofecoxib	COX-2	MESH:C116926	5743	Chemical	Gene	Use|nmod|START_ENTITY Aspirin|dep|Use Inhibition|nmod|Aspirin Inhibition|compound|END_ENTITY	COX-2 Inhibition by Use of Rofecoxib or High Dose Aspirin Enhances ADP-Induced Platelet Aggregation in Fresh Blood .
16985100	0	Rofecoxib	0,9	CYP1A2	57,63	Rofecoxib	CYP1A2	MESH:C116926	1544	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Rofecoxib is a potent , metabolism-dependent inhibitor of CYP1A2 : implications for in vitro prediction of drug interactions .
19372053	0	Rofecoxib	70,79	Cox-2	83,88	Rofecoxib	Cox-2	MESH:C116926	19225(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Prevention of urinary_bladder_cancer in the FHIT knock-out mouse with Rofecoxib , a Cox-2 inhibitor .
10411562	0	Rofecoxib	0,9	cyclooxygenase-2	109,125	Rofecoxib	cyclooxygenase-2	MESH:C116926	5743	Chemical	Gene	Vioxx|compound|START_ENTITY Vioxx|dep|-RSB- -RSB-|dep|inhibitor inhibitor|amod|END_ENTITY	Rofecoxib -LSB- Vioxx , MK-0966 ; 4 - -LRB- 4 ' - methylsulfonylphenyl -RRB- -3 - phenyl-2 - -LRB- 5H -RRB- - furanone -RSB- : a potent and orally active cyclooxygenase-2 inhibitor .
10511349	0	Rofecoxib	0,9	cyclooxygenase-2	22,38	Rofecoxib	cyclooxygenase-2	MESH:C116926	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Rofecoxib , a specific cyclooxygenase-2 inhibitor , in primary_dysmenorrhea : a randomized controlled trial .
12902858	0	Rofecoxib	0,9	cyclooxygenase-2	30,46	Rofecoxib	cyclooxygenase-2	MESH:C116926	19225(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Rofecoxib -LRB- Vioxx -RRB- , a specific cyclooxygenase-2 inhibitor , is chemopreventive in a mouse model of colon_cancer .
16580899	0	Rofecoxib	0,9	cyclooxygenase-2	142,158	Rofecoxib	cyclooxygenase-2	MESH:C116926	5743	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|genes genes|dep|implication implication|nmod|effects effects|nmod|inhibitors inhibitors|amod|END_ENTITY	Rofecoxib regulates the expression of genes related to the matrix metalloproteinase pathway in humans : implication for the adverse effects of cyclooxygenase-2 inhibitors .
17139446	0	Rofecoxib	0,9	cyclooxygenase-2	23,39	Rofecoxib	cyclooxygenase-2	MESH:C116926	19225(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Rofecoxib , a selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitor potentiates the anticonvulsant activity of tiagabine against pentylenetetrazol-induced convulsions in mice .
18054463	0	Rofecoxib	0,9	cyclooxygenase-2	23,39	Rofecoxib	cyclooxygenase-2	MESH:C116926	19225(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Rofecoxib , a selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitor increases pentylenetetrazol seizure threshold in mice : possible involvement of adenosinergic mechanism .
21990143	0	Rofecoxib	0,9	cyclooxygenase-2	83,99	Rofecoxib	cyclooxygenase-2	MESH:C116926	5743	Chemical	Gene	analogues|nsubj|START_ENTITY analogues|xcomp|possessing possessing|dobj|acid acid|dep|pharmacophore pharmacophore|amod|END_ENTITY	Rofecoxib analogues possessing a nitric_oxide donor sulfohydroxamic acid -LRB- SO2NHOH -RRB- cyclooxygenase-2 pharmacophore : synthesis , molecular modeling , and biological evaluation as anti-inflammatory agents .
25472856	0	Rofecoxib	0,9	cyclooxygenase-2	69,85	Rofecoxib	cyclooxygenase-2	MESH:C116926	19225(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|retinal_neovascularization retinal_neovascularization|nmod|regulation regulation|nmod|expression expression|amod|END_ENTITY	Rofecoxib inhibits retinal_neovascularization via down regulation of cyclooxygenase-2 and vascular_endothelial_growth_factor expression .
10817549	0	Rofecoxib	0,9	cyclooxygenase_2	35,51	Rofecoxib	cyclooxygenase 2	MESH:C116926	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Rofecoxib , a specific inhibitor of cyclooxygenase_2 , with clinical efficacy comparable with that of diclofenac_sodium : results of a one-year , randomized , clinical trial in patients with osteoarthritis of the knee and hip .
11115219	0	Rofecoxib	0,9	cyclooxygenase_2	17,33	Rofecoxib	cyclooxygenase 2	MESH:C116926	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Rofecoxib , a new cyclooxygenase_2 inhibitor , shows sustained efficacy , comparable with other nonsteroidal anti-inflammatory drugs : a 6-week and a 1-year trial in patients with osteoarthritis .
12105834	0	Rofecoxib	0,9	cyclooxygenase_2	19,35	Rofecoxib	cyclooxygenase 2	MESH:C116926	5743	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Rofecoxib inhibits cyclooxygenase_2 expression and activity and reduces cell proliferation in Barrett 's _ esophagus .
16934051	0	Rofecoxib	0,9	cytochrome_P450_1A2	35,54	Rofecoxib	cytochrome P450 1A2	MESH:C116926	1544	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Rofecoxib is a potent inhibitor of cytochrome_P450_1A2 : studies with tizanidine and caffeine in healthy subjects .
19811374	0	Roflumilast	0,11	Clara_cell_secretory_protein	22,50	Roflumilast	Clara cell secretory protein	MESH:C424423	22287(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Roflumilast increases Clara_cell_secretory_protein in cigarette smoke-exposed mice .
18447606	0	Roflumilast	0,11	PDE-4	43,48	Roflumilast	PDE-4	MESH:C424423	5141	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Roflumilast : an oral , once-daily selective PDE-4 inhibitor for the management of COPD and asthma .
22084617	0	Roflumilast	0,11	Phosphodiesterase_4	21,40	Roflumilast	Phosphodiesterase 4	MESH:C424423	5141	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|compound|END_ENTITY	Roflumilast , a Novel Phosphodiesterase_4 Inhibitor , for COPD Patients with a History of Exacerbations .
24066150	0	Roflumilast	0,11	tumor_necrosis_factor-a	48,71	Roflumilast	tumor necrosis factor-a	MESH:C424423	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Roflumilast inhibits lipopolysaccharide-induced tumor_necrosis_factor-a and chemokine production by human lung parenchyma .
22385203	0	Roflumilast_N-oxide	0,19	PDE4	23,27	Roflumilast N-oxide	PDE4	MESH:C517734	5141	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Roflumilast_N-oxide , a PDE4 inhibitor , improves cilia motility and ciliated human bronchial epithelial cells compromised by cigarette smoke in vitro .
15744818	0	Rolipram	0,8	inducible_cAMP_early_repressor	54,84	Rolipram	inducible cAMP early repressor	MESH:D020889	1390	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	Rolipram , a phosphodiesterase 4 inhibitor , stimulates inducible_cAMP_early_repressor expression in osteoblasts .
6545426	0	Rollin	45,51	LRP	12,15	Rollin	LRP	null	4035	Chemical	Gene	enhancement|nmod|START_ENTITY enhancement|compound|END_ENTITY	PHA-induced LRP enhancement of normal PBL by Rollin .
20624163	0	Romidepsin	0,10	histone_deacetylase	29,48	Romidepsin	histone deacetylase	MESH:C087123	9734	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Romidepsin -LRB- FK228 -RRB- , a potent histone_deacetylase inhibitor , induces apoptosis through the generation of hydrogen_peroxide .
16339073	0	Rootletin	0,9	C-Nap1	25,31	Rootletin	C-Nap1	null	11190	Chemical	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Rootletin interacts with C-Nap1 and may function as a physical linker between the pair of centrioles/basal bodies in cells .
10389787	1	Ropivacaine	183,194	Hip	195,198	Ropivacaine	Hip	MESH:C037663	6767	Chemical	Gene	Group|compound|START_ENTITY Group|compound|END_ENTITY	Ropivacaine Hip Replacement Multicenter Study Group .
14679020	0	Roscovitine	0,11	STAT5	21,26	Roscovitine	STAT5	MESH:C104586	6776	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	Roscovitine inhibits STAT5 activity and induces apoptosis in the human leukemia virus type 1-transformed cell line MT-2 .
17081516	0	Roscovitine	0,11	cdk5	127,131	Roscovitine	cdk5	MESH:C104586	1020	Chemical	Gene	regulates|advmod|START_ENTITY regulates|nsubj|cell cell|dep|proliferation proliferation|nmod|END_ENTITY	Roscovitine regulates invasive breast_cancer cell -LRB- MDA-MB231 -RRB- proliferation and survival through cell cycle regulatory protein cdk5 .
26643379	0	Rosiglitazone	89,102	AMP-activated_Protein_Kinase	0,28	Rosiglitazone	AMP-activated Protein Kinase	MESH:C089730	78975(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Mediates|dobj|Effects Mediates|nsubj|END_ENTITY	AMP-activated_Protein_Kinase Mediates the Antiplatelet Effects of the Thiazolidinediones Rosiglitazone and Pioglitazone .
23109223	0	Rosiglitazone	0,13	AMP-activated_protein_kinase	110,138	Rosiglitazone	AMP-activated protein kinase	MESH:C089730	5564	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|activation activation|nmod|autophagy autophagy|nmod|5 5|dep|modulation modulation|amod|END_ENTITY	Rosiglitazone protects against palmitate-induced pancreatic beta-cell death by activation of autophagy via 5 ' - AMP-activated_protein_kinase modulation .
21034554	0	Rosiglitazone	0,13	AMPK	59,63	Rosiglitazone	AMPK	MESH:C089730	78975(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	Rosiglitazone reduces fatty_acid translocase and increases AMPK in skeletal muscle in aged rats : a possible mechanism to prevent high-fat-induced insulin resistance .
25662477	0	Rosiglitazone	0,13	AQP2	23,27	Rosiglitazone	AQP2	MESH:C089730	359	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Rosiglitazone Promotes AQP2 Plasma Membrane Expression In Renal Cells Via a Ca-Dependent/cAMP-Independent Mechanism .
19808911	0	Rosiglitazone	0,13	C-reactive_protein	24,42	Rosiglitazone	C-reactive protein	MESH:C089730	1401	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|xcomp|END_ENTITY	Rosiglitazone decreases C-reactive_protein to a greater extent relative to glyburide and metformin over 4 years despite greater weight_gain : observations from a Diabetes Outcome Progression Trial -LRB- ADOPT -RRB- .
22659808	0	Rosiglitazone	0,13	C-reactive_protein	46,64	Rosiglitazone	C-reactive protein	MESH:C089730	1401	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Rosiglitazone inhibits angiotensin_II-induced C-reactive_protein production in human aortic endothelial cells through regulating AT -LRB- 1 -RRB- - ROS-MAPK signal pathway .
26741265	0	Rosiglitazone	0,13	C-reactive_protein	48,66	Rosiglitazone	C-reactive protein	MESH:C089730	25419(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|amod|END_ENTITY	Rosiglitazone attenuates angiotensin_II-induced C-reactive_protein expression in hepatocytes via inhibiting AT1/ROS/MAPK signal pathway .
17074304	0	Rosiglitazone	0,13	CTGF	46,50	Rosiglitazone	CTGF	MESH:C089730	64032(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Rosiglitazone inhibits angiotensin_II-induced CTGF expression in vascular smooth muscle cells - role of PPAR-gamma in vascular fibrosis .
20026082	0	Rosiglitazone	0,13	GLUT4	37,42	Rosiglitazone	GLUT4	MESH:C089730	6517	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|compound|END_ENTITY	Rosiglitazone increases cell surface GLUT4 levels in 3T3-L1 adipocytes through an enhancement of endosomal recycling .
17583675	0	Rosiglitazone	0,13	ICAM-1	45,51	Rosiglitazone	ICAM-1	MESH:C089730	3383	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|END_ENTITY	Rosiglitazone attenuates NF-kappaB-dependent ICAM-1 and TNF-alpha production caused by homocysteine via inhibiting ERK1/2/p38MAPK activation .
15073165	0	Rosiglitazone	0,13	Insig-1	27,34	Rosiglitazone	Insig-1	MESH:C089730	3638	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Rosiglitazone induction of Insig-1 in white adipose tissue reveals a novel interplay of peroxisome_proliferator-activated_receptor_gamma and sterol_regulatory_element-binding_protein in the regulation of adipogenesis .
24424059	0	Rosiglitazone	0,13	PEDF	51,55	Rosiglitazone	PEDF	MESH:C089730	287526(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Rosiglitazone inhibits expression and secretion of PEDF in adipose tissue and liver of male SD rats via a PPAR-y independent mechanism .
12970094	0	Rosiglitazone	0,13	PPAR-gamma	121,131	Rosiglitazone	PPAR-gamma	MESH:C089730	25664(Tax:10116)	Chemical	Gene	START_ENTITY|appos|ligands ligands|nmod|peroxisome_proliferator-activated_receptor-gamma peroxisome_proliferator-activated_receptor-gamma|appos|END_ENTITY	Rosiglitazone and 15-deoxy-Delta12 ,14 - prostaglandin_J2 , ligands of the peroxisome_proliferator-activated_receptor-gamma -LRB- PPAR-gamma -RRB- , reduce ischaemia/reperfusion injury of the gut .
15726020	0	Rosiglitazone	0,13	PPAR-gamma	15,25	Rosiglitazone	PPAR-gamma	MESH:C089730	25664(Tax:10116)	Chemical	Gene	ligand|advmod|START_ENTITY ligand|nsubj|receptor receptor|amod|END_ENTITY	Rosiglitazone , PPAR-gamma receptor ligand , decreases the viability of rat prolactin-secreting pituitary_tumor cells in vitro .
15950942	0	Rosiglitazone	26,39	PPAR-gamma	4,14	Rosiglitazone	PPAR-gamma	MESH:C089730	5468	Chemical	Gene	activator|appos|START_ENTITY activator|amod|END_ENTITY	The PPAR-gamma activator , Rosiglitazone , inhibits actin polymerisation in monocytes : involvement of Akt and intracellular calcium .
17074304	0	Rosiglitazone	0,13	PPAR-gamma	104,114	Rosiglitazone	PPAR-gamma	MESH:C089730	25664(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|dep|role role|nmod|END_ENTITY	Rosiglitazone inhibits angiotensin_II-induced CTGF expression in vascular smooth muscle cells - role of PPAR-gamma in vascular fibrosis .
17467912	0	Rosiglitazone	0,13	PPAR-gamma	17,27	Rosiglitazone	PPAR-gamma	MESH:C089730	25664(Tax:10116)	Chemical	Gene	START_ENTITY|appos|ligand ligand|amod|END_ENTITY	Rosiglitazone , a PPAR-gamma ligand , protects against burn-induced oxidative injury of remote organs .
19349877	0	Rosiglitazone	0,13	PPAR-gamma	17,27	Rosiglitazone	PPAR-gamma	MESH:C089730	25664(Tax:10116)	Chemical	Gene	START_ENTITY|appos|ligand ligand|amod|END_ENTITY	Rosiglitazone , a PPAR-gamma ligand , reduces burn progression in rats .
18479673	0	Rosiglitazone	0,13	PPAR_gamma	17,27	Rosiglitazone	PPAR gamma	MESH:C089730	25664(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Rosiglitazone , a PPAR_gamma agonist , attenuates_inflammation after surgical brain_injury in rodents .
18712722	0	Rosiglitazone	0,13	PPAR_gamma	17,27	Rosiglitazone	PPAR gamma	MESH:C089730	25664(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Rosiglitazone , a PPAR_gamma agonist : potent promoter of hydroxybutyl -LRB- butyl -RRB- nitrosamine-induced urinary_bladder_cancers .
14556646	0	Rosiglitazone	0,13	PPARgamma	79,88	Rosiglitazone	PPARgamma	MESH:C089730	5468	Chemical	Gene	START_ENTITY|appos|agonist agonist|nmod|peroxisome-proliferator-activated_receptor_gamma peroxisome-proliferator-activated_receptor_gamma|appos|END_ENTITY	Rosiglitazone , an agonist of peroxisome-proliferator-activated_receptor_gamma -LRB- PPARgamma -RRB- , decreases inhibitory serine phosphorylation of IRS1 in vitro and in vivo .
17343846	0	Rosiglitazone	0,13	PPARgamma	17,26	Rosiglitazone	PPARgamma	MESH:C089730	25664(Tax:10116)	Chemical	Gene	ligand|advmod|START_ENTITY ligand|nsubj|END_ENTITY	Rosiglitazone , a PPARgamma ligand , modulates signal transduction pathways during the development of acute TNBS-induced colitis in rats .
17597835	0	Rosiglitazone	0,13	PPARgamma	29,38	Rosiglitazone	PPARgamma	MESH:C089730	5468	Chemical	Gene	START_ENTITY|appos|Agonist Agonist|nmod|END_ENTITY	Rosiglitazone , an Agonist of PPARgamma , Inhibits Non-Small_Cell_Carcinoma Cell Proliferation In Part through Activation of Tumor_Sclerosis_Complex-2 .
17622750	0	Rosiglitazone	0,13	PPARgamma	24,33	Rosiglitazone	PPARgamma	MESH:C089730	281993(Tax:9913)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Rosiglitazone increases PPARgamma in renal tubular epithelial cells and protects against damage by hydrogen_peroxide .
17765245	0	Rosiglitazone	0,13	PPARgamma	191,200	Rosiglitazone	PPARgamma	MESH:C089730	5468	Chemical	Gene	produces|nsubj|START_ENTITY produces|parataxis|mediated mediated|nmod|activation activation|compound|END_ENTITY	Rosiglitazone produces a greater reduction in circulating platelet activity compared with gliclazide in patients with type_2_diabetes_mellitus -- an effect probably mediated by direct platelet PPARgamma activation .
18640979	0	Rosiglitazone	0,13	PPARgamma	165,174	Rosiglitazone	PPARgamma	MESH:C089730	5468	Chemical	Gene	treatment|amod|START_ENTITY prevents|nsubj|treatment prevents|parataxis|role role|nmod|peroxisome_proliferator-activated_receptor-gamma peroxisome_proliferator-activated_receptor-gamma|appos|END_ENTITY	Rosiglitazone treatment prevents mitochondrial_dysfunction in mutant huntingtin-expressing cells : possible role of peroxisome_proliferator-activated_receptor-gamma -LRB- PPARgamma -RRB- in the pathogenesis of Huntington_disease .
18810275	0	Rosiglitazone	0,13	PPARgamma	116,125	Rosiglitazone	PPARgamma	MESH:C089730	5468	Chemical	Gene	Suppresses|nsubj|START_ENTITY Suppresses|xcomp|Growth Growth|dep|Vitro Vitro|nmod|Dependent Dependent|compound|END_ENTITY	Rosiglitazone Suppresses the Growth and Invasiveness of SGC-7901 Gastric_Cancer Cells and Angiogenesis In Vitro via PPARgamma Dependent and Independent Mechanisms .
19114961	0	Rosiglitazone	0,13	PPARgamma	67,76	Rosiglitazone	PPARgamma	MESH:C089730	5468	Chemical	Gene	START_ENTITY|appos|peroxisome_proliferator-activated_receptor_gamma peroxisome_proliferator-activated_receptor_gamma|appos|END_ENTITY	Rosiglitazone , a peroxisome_proliferator-activated_receptor_gamma -LRB- PPARgamma -RRB- - specific agonist , as a modulator in experimental acute pancreatitis .
19684609	0	Rosiglitazone	0,13	PPARgamma	124,133	Rosiglitazone	PPARgamma	MESH:C089730	5468	Chemical	Gene	sensitizes|nsubj|START_ENTITY sensitizes|nmod|activation activation|nmod|pathway pathway|compound|END_ENTITY	Rosiglitazone sensitizes hepatocellular_carcinoma cell lines to 5-fluorouracil antitumor activity through activation of the PPARgamma signaling pathway .
19850645	0	Rosiglitazone	0,13	PPARgamma	28,37	Rosiglitazone	PPARgamma	MESH:C089730	5468	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|suppresses suppresses|compound|END_ENTITY	Rosiglitazone activation of PPARgamma suppresses fractalkine signaling .
24370585	0	Rosiglitazone	0,13	PPARgamma	85,94	Rosiglitazone	PPARgamma	MESH:C089730	19016(Tax:10090)	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|outgrowth outgrowth|nmod|cells cells|nmod|END_ENTITY	Rosiglitazone promotes neurite outgrowth and mitochondrial function in N2A cells via PPARgamma pathway .
25144187	0	Rosiglitazone	0,13	TGF-b_1	23,30	Rosiglitazone	TGF-b 1	MESH:C089730	7040	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Rosiglitazone inhibits TGF-b_1 induced activation of human Tenon fibroblasts via p38 signal pathway .
21986923	0	Rosiglitazone	0,13	VEGF	42,46	Rosiglitazone	VEGF	MESH:C089730	7422	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|amod|END_ENTITY	Rosiglitazone , a PPAR-y agonist , inhibits VEGF secretion by peripheral blood mononuclear cells and ROS production by human leukocytes .
25136257	0	Rosiglitazone	0,13	apolipoprotein_M	23,39	Rosiglitazone	apolipoprotein M	MESH:C089730	55939(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Rosiglitazone enhances apolipoprotein_M -LRB- Apom -RRB- expression in rat 's liver .
15314095	0	Rosiglitazone	0,13	caveolin-1	26,36	Rosiglitazone	caveolin-1	MESH:C089730	857	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Rosiglitazone upregulates caveolin-1 expression in THP-1 cells through a PPAR-dependent mechanism .
18507034	0	Rosiglitazone	0,13	caveolin-1	22,32	Rosiglitazone	caveolin-1	MESH:C089730	857	Chemical	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Rosiglitazone induces caveolin-1 by PPARgamma-dependent and PPRE-independent mechanisms : the role of EGF_receptor signaling and its effect on cancer cell drug resistance .
10577070	1	Rosiglitazone	28,41	insulin	63,70	Rosiglitazone	insulin	MESH:C089730	3630	Chemical	Gene	effective|nsubj|START_ENTITY effective|nmod|-RSB- -RSB-|compound|END_ENTITY	Rosiglitazone is effective against insulin resistance -RSB- .
15579757	0	Rosiglitazone	0,13	insulin	84,91	Rosiglitazone	insulin	MESH:C089730	3630	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|xcomp|circulating circulating|dobj|proinsulin proinsulin|dep|ratio ratio|compound|END_ENTITY	Rosiglitazone , but not glyburide , reduces circulating proinsulin and the proinsulin : insulin ratio in type 2 diabetes .
16046313	0	Rosiglitazone	0,13	insulin	41,48	Rosiglitazone	insulin	MESH:C089730	3630	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|rate rate|compound|END_ENTITY	Rosiglitazone reduces glucose-stimulated insulin secretion rate and increases insulin clearance in nondiabetic , insulin-resistant individuals .
17189867	0	Rosiglitazone	0,13	insulin	131,138	Rosiglitazone	insulin	MESH:C089730	3630	Chemical	Gene	START_ENTITY|dep|safety safety|nmod|combination combination|nmod|insulin insulin|nmod|patients patients|acl|treated treated|nmod|END_ENTITY	Rosiglitazone : safety and efficacy in combination with insulin in poorly controlled type_2_diabetes_mellitus patients treated with insulin alone .
17189867	0	Rosiglitazone	0,13	insulin	55,62	Rosiglitazone	insulin	MESH:C089730	3630	Chemical	Gene	START_ENTITY|dep|safety safety|nmod|combination combination|nmod|END_ENTITY	Rosiglitazone : safety and efficacy in combination with insulin in poorly controlled type_2_diabetes_mellitus patients treated with insulin alone .
18191635	0	Rosiglitazone	0,13	insulin	54,61	Rosiglitazone	insulin	MESH:C089730	3630	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|nmod|END_ENTITY	Rosiglitazone stimulates the release and synthesis of insulin by enhancing GLUT-2 , glucokinase and BETA2/NeuroD expression .
20191245	0	Rosiglitazone	0,13	insulin	61,68	Rosiglitazone	insulin	MESH:C089730	3630	Chemical	Gene	add-on|compound|START_ENTITY add-on|nmod|treatment treatment|nmod|patients patients|nmod|resistance resistance|compound|END_ENTITY	Rosiglitazone add-on in treatment of depressed patients with insulin resistance : a pilot study .
24683546	0	Rosiglitazone	0,13	klotho	33,39	Rosiglitazone	klotho	MESH:C089730	83504(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Rosiglitazone increases cerebral klotho expression to reverse baroreflex in type 1-like diabetic rats .
18394743	0	Rosiglitazone	0,13	leptin	64,70	Rosiglitazone	leptin	MESH:C089730	3952	Chemical	Gene	improves|nsubj|START_ENTITY improves|nmod|levels levels|compound|END_ENTITY	Rosiglitazone improves insulin sensitivity with increased serum leptin levels in patients with type_2_diabetes_mellitus .
21726411	0	Rosiglitazone	0,13	osteoprotegerin	41,56	Rosiglitazone	osteoprotegerin	MESH:C089730	4982	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|levels levels|nmod|END_ENTITY	Rosiglitazone decreases plasma levels of osteoprotegerin in a randomized clinical trial with type 2 diabetes patients .
14556646	0	Rosiglitazone	0,13	peroxisome-proliferator-activated_receptor_gamma	29,77	Rosiglitazone	peroxisome-proliferator-activated receptor gamma	MESH:C089730	5468	Chemical	Gene	START_ENTITY|appos|agonist agonist|nmod|END_ENTITY	Rosiglitazone , an agonist of peroxisome-proliferator-activated_receptor_gamma -LRB- PPARgamma -RRB- , decreases inhibitory serine phosphorylation of IRS1 in vitro and in vivo .
12970094	0	Rosiglitazone	0,13	peroxisome_proliferator-activated_receptor-gamma	71,119	Rosiglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C089730	25664(Tax:10116)	Chemical	Gene	START_ENTITY|appos|ligands ligands|nmod|END_ENTITY	Rosiglitazone and 15-deoxy-Delta12 ,14 - prostaglandin_J2 , ligands of the peroxisome_proliferator-activated_receptor-gamma -LRB- PPAR-gamma -RRB- , reduce ischaemia/reperfusion injury of the gut .
14709329	0	Rosiglitazone	0,13	peroxisome_proliferator-activated_receptor-gamma	31,79	Rosiglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C089730	25664(Tax:10116)	Chemical	Gene	START_ENTITY|appos|ligand ligand|nmod|END_ENTITY	Rosiglitazone , a ligand of the peroxisome_proliferator-activated_receptor-gamma , reduces acute inflammation .
14758164	0	Rosiglitazone	0,13	peroxisome_proliferator-activated_receptor-gamma	31,79	Rosiglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C089730	19016(Tax:10090)	Chemical	Gene	START_ENTITY|appos|ligand ligand|nmod|END_ENTITY	Rosiglitazone , a ligand of the peroxisome_proliferator-activated_receptor-gamma , reduces the development of nonseptic_shock induced by zymosan in mice .
14985957	0	Rosiglitazone	0,13	peroxisome_proliferator-activated_receptor-gamma	31,79	Rosiglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C089730	19016(Tax:10090)	Chemical	Gene	START_ENTITY|appos|ligand ligand|nmod|END_ENTITY	Rosiglitazone , a ligand of the peroxisome_proliferator-activated_receptor-gamma , reduces acute pancreatitis induced by cerulein .
16215386	0	Rosiglitazone	0,13	peroxisome_proliferator-activated_receptor-gamma	17,65	Rosiglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C089730	25664(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Rosiglitazone , a peroxisome_proliferator-activated_receptor-gamma agonist , reduces acute_lung_injury in endotoxemic rats .
17042914	0	Rosiglitazone	0,13	peroxisome_proliferator-activated_receptor-gamma	17,65	Rosiglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C089730	25664(Tax:10116)	Chemical	Gene	START_ENTITY|appos|ligand ligand|amod|END_ENTITY	Rosiglitazone , a peroxisome_proliferator-activated_receptor-gamma ligand , reduces infarction volume and neurological_deficits in an embolic model of stroke .
17439415	0	Rosiglitazone	0,13	peroxisome_proliferator-activated_receptor-gamma	29,77	Rosiglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C089730	25664(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|nmod|END_ENTITY	Rosiglitazone , an agonist of peroxisome_proliferator-activated_receptor-gamma , prevents contralateral testicular ischaemia-reperfusion injury in prepubertal rats .
18039959	0	Rosiglitazone	0,13	peroxisome_proliferator-activated_receptor-gamma	17,65	Rosiglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C089730	19016(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Rosiglitazone , a peroxisome_proliferator-activated_receptor-gamma agonist , prevents microparticle-induced vascular_hyporeactivity through the regulation of proinflammatory proteins .
18630997	0	Rosiglitazone	0,13	peroxisome_proliferator-activated_receptor-gamma	164,212	Rosiglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C089730	5468	Chemical	Gene	effect|amod|START_ENTITY effect|dep|correlation correlation|nmod|expression expression|nmod|END_ENTITY	Rosiglitazone effect on radioiodine uptake in thyroid_carcinoma patients with high thyroglobulin but negative total_body_scan : a correlation with the expression of peroxisome_proliferator-activated_receptor-gamma .
18640979	0	Rosiglitazone	0,13	peroxisome_proliferator-activated_receptor-gamma	115,163	Rosiglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C089730	5468	Chemical	Gene	treatment|amod|START_ENTITY prevents|nsubj|treatment prevents|parataxis|role role|nmod|END_ENTITY	Rosiglitazone treatment prevents mitochondrial_dysfunction in mutant huntingtin-expressing cells : possible role of peroxisome_proliferator-activated_receptor-gamma -LRB- PPARgamma -RRB- in the pathogenesis of Huntington_disease .
19464576	0	Rosiglitazone	0,13	peroxisome_proliferator-activated_receptor-gamma	17,65	Rosiglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C089730	25664(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Rosiglitazone , a peroxisome_proliferator-activated_receptor-gamma agonist , attenuates acrolein-induced airway mucus hypersecretion in rats .
19520784	0	Rosiglitazone	0,13	peroxisome_proliferator-activated_receptor-gamma	42,90	Rosiglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C089730	443513(Tax:9940)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|genes genes|amod|END_ENTITY	Rosiglitazone increases the expression of peroxisome_proliferator-activated_receptor-gamma target genes in adipose tissue , liver , and skeletal muscle in the sheep fetus in late gestation .
15073165	0	Rosiglitazone	0,13	peroxisome_proliferator-activated_receptor_gamma	88,136	Rosiglitazone	peroxisome proliferator-activated receptor gamma	MESH:C089730	5468	Chemical	Gene	induction|amod|START_ENTITY reveals|nsubj|induction reveals|dobj|interplay interplay|nmod|END_ENTITY	Rosiglitazone induction of Insig-1 in white adipose tissue reveals a novel interplay of peroxisome_proliferator-activated_receptor_gamma and sterol_regulatory_element-binding_protein in the regulation of adipogenesis .
15556153	0	Rosiglitazone	0,13	peroxisome_proliferator-activated_receptor_gamma	29,77	Rosiglitazone	peroxisome proliferator-activated receptor gamma	MESH:C089730	25664(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|nmod|END_ENTITY	Rosiglitazone , an agonist of peroxisome_proliferator-activated_receptor_gamma , protects against gastric_ischemia-reperfusion damage in rats : role of oxygen free radicals generation .
15876425	0	Rosiglitazone	0,13	peroxisome_proliferator-activated_receptor_gamma	29,77	Rosiglitazone	peroxisome proliferator-activated receptor gamma	MESH:C089730	25664(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|nmod|END_ENTITY	Rosiglitazone , an agonist of peroxisome_proliferator-activated_receptor_gamma , reduces chronic colonic_inflammation in rats .
16307220	0	Rosiglitazone	0,13	peroxisome_proliferator-activated_receptor_gamma	29,77	Rosiglitazone	peroxisome proliferator-activated receptor gamma	MESH:C089730	25664(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|nmod|END_ENTITY	Rosiglitazone , an agonist of peroxisome_proliferator-activated_receptor_gamma , reduces pulmonary inflammatory response in a rat model of endotoxemia .
17461445	0	Rosiglitazone	0,13	peroxisome_proliferator-activated_receptor_gamma	83,131	Rosiglitazone	peroxisome proliferator-activated receptor gamma	MESH:C089730	5468	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|advcl|activating activating|dobj|END_ENTITY	Rosiglitazone enhances fluorouracil-induced apoptosis of HT-29 cells by activating peroxisome_proliferator-activated_receptor_gamma .
20298677	0	Rosiglitazone	0,13	peroxisome_proliferator-activated_receptor_gamma	29,77	Rosiglitazone	peroxisome proliferator-activated receptor gamma	MESH:C089730	19016(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonist agonist|nmod|END_ENTITY	Rosiglitazone , an agonist of peroxisome_proliferator-activated_receptor_gamma , decreases immunoreactivity of markers for cell proliferation and neuronal differentiation in the mouse hippocampus .
24681211	0	Rosiglitazone	0,13	peroxisome_proliferator-activated_receptor_gamma	25,73	Rosiglitazone	peroxisome proliferator-activated receptor gamma	MESH:C089730	397671(Tax:9823)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Rosiglitazone stimulates peroxisome_proliferator-activated_receptor_gamma expression and directly affects in vitro steroidogenesis in porcine ovarian follicles .
18953895	0	Rosiglitazone	11,24	transforming_growth_factor-beta_1	68,101	Rosiglitazone	transforming growth factor-beta 1	MESH:C089730	7040	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Effect of Rosiglitazone on the proliferation and the production of transforming_growth_factor-beta_1 in cultured human Tenon ' s capsule fibroblasts -RSB- .
19609456	0	Rosiglitazone	0,13	vascular_endothelial_growth_factor	44,78	Rosiglitazone	vascular endothelial growth factor	MESH:C089730	83785(Tax:10116)	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|dobj|END_ENTITY	Rosiglitazone prevents high glucose-induced vascular_endothelial_growth_factor and collagen IV expression in cultured mesangial cells .
19856917	0	Rosmanol	0,8	iNOS	54,58	Rosmanol	iNOS	MESH:C465581	18126(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Rosmanol potently inhibits lipopolysaccharide-induced iNOS and COX-2 expression through downregulating MAPK , NF-kappaB , STAT3 and C/EBP signaling pathways .
16604092	0	Rosmarinic_acid	0,15	CCL11	91,96	Rosmarinic acid	CCL11	MESH:C041376	6356	Chemical	Gene	START_ENTITY|nmod|upregulation upregulation|nmod|END_ENTITY	Rosmarinic_acid as a downstream inhibitor of IKK-beta in TNF-alpha-induced upregulation of CCL11 and CCR3 .
23774263	0	Rosmarinic_acid	0,15	endothelial_protein_C_receptor	31,61	Rosmarinic acid	endothelial protein C receptor	MESH:C041376	10544	Chemical	Gene	down-regulates|amod|START_ENTITY END_ENTITY|nsubj|down-regulates	Rosmarinic_acid down-regulates endothelial_protein_C_receptor shedding in vitro and in vivo .
26271127	0	Rosuvastatin	24,36	C-Reactive_Protein	83,101	Rosuvastatin	C-Reactive Protein	MESH:C422923	1401	Chemical	Gene	Comparing|dobj|START_ENTITY Comparing|advcl|Reducing Reducing|dobj|Concentration Concentration|nmod|END_ENTITY	Meta-Analysis Comparing Rosuvastatin and Atorvastatin in Reducing Concentration of C-Reactive_Protein in Patients With Hyperlipidemia .
17595889	0	Rosuvastatin	0,12	C-reactive_protein	57,75	Rosuvastatin	C-reactive protein	MESH:C422923	1401	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|nmod|END_ENTITY	Rosuvastatin reduces interleukin-6-induced expression of C-reactive_protein in human hepatocytes in a STAT3 - and C/EBP-dependent fashion .
18997196	0	Rosuvastatin	0,12	C-reactive_protein	71,89	Rosuvastatin	C-reactive protein	MESH:C422923	1401	Chemical	Gene	START_ENTITY|xcomp|prevent prevent|nmod|END_ENTITY	Rosuvastatin to prevent vascular events in men and women with elevated C-reactive_protein .
20026779	0	Rosuvastatin	0,12	C-reactive_protein	85,103	Rosuvastatin	C-reactive protein	MESH:C422923	1401	Chemical	Gene	START_ENTITY|nmod|prevention prevention|nmod|stroke stroke|nmod|men men|nmod|levels levels|nmod|END_ENTITY	Rosuvastatin in the prevention of stroke among men and women with elevated levels of C-reactive_protein : justification for the Use of Statins in Prevention : an Intervention Trial Evaluating Rosuvastatin -LRB- JUPITER -RRB- .
20026779	0	Rosuvastatin	190,202	C-reactive_protein	85,103	Rosuvastatin	C-reactive protein	MESH:C422923	1401	Chemical	Gene	Intervention|dep|START_ENTITY Rosuvastatin|dep|Intervention Rosuvastatin|nmod|prevention prevention|nmod|stroke stroke|nmod|men men|nmod|levels levels|nmod|END_ENTITY	Rosuvastatin in the prevention of stroke among men and women with elevated levels of C-reactive_protein : justification for the Use of Statins in Prevention : an Intervention Trial Evaluating Rosuvastatin -LRB- JUPITER -RRB- .
20176986	0	Rosuvastatin	238,250	C-reactive_protein	100,118	Rosuvastatin	C-reactive protein	MESH:C422923	1401	Chemical	Gene	Intervention|dep|START_ENTITY Statins|dep|Intervention Statins|nmod|prevention prevention|nmod|cardiovascular_events cardiovascular_events|nmod|women women|nmod|END_ENTITY	Statins for the primary prevention of cardiovascular_events in women with elevated high-sensitivity C-reactive_protein or dyslipidemia : results from the Justification for the Use of Statins in Prevention : An Intervention Trial Evaluating Rosuvastatin -LRB- JUPITER -RRB- and meta-analysis of women from primary prevention trials .
20404379	0	Rosuvastatin	0,12	C-reactive_protein	67,85	Rosuvastatin	C-reactive protein	MESH:C422923	1401	Chemical	Gene	START_ENTITY|nmod|prevention prevention|nmod|persons persons|nmod|levels levels|compound|END_ENTITY	Rosuvastatin for primary prevention in older persons with elevated C-reactive_protein and low to average low-density lipoprotein cholesterol levels : exploratory analysis of a randomized trial .
21094359	0	Rosuvastatin	156,168	C-reactive_protein	108,126	Rosuvastatin	C-reactive protein	MESH:C422923	1401	Chemical	Gene	treatment|nmod|START_ENTITY polymorphisms|nmod|treatment polymorphisms|nmod|levels levels|amod|END_ENTITY	Effect of central_obesity , low high-density lipoprotein cholesterol and C-reactive_protein polymorphisms on C-reactive_protein levels during treatment with Rosuvastatin -LRB- 10 mg Daily -RRB- .
21267417	0	Rosuvastatin	0,12	C-reactive_protein	28,46	Rosuvastatin	C-reactive protein	MESH:C422923	1401	Chemical	Gene	JUPITER|compound|START_ENTITY JUPITER|appos|END_ENTITY	Rosuvastatin , inflammation , C-reactive_protein , JUPITER , and primary prevention of cardiovascular_disease -- a perspective .
21562509	0	Rosuvastatin	0,12	C-reactive_protein	91,109	Rosuvastatin	C-reactive protein	MESH:C422923	1401	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|elevation elevation|nmod|pressure pressure|acl|induced induced|nmod|overexpression overexpression|nmod|END_ENTITY	Rosuvastatin attenuates the elevation in blood pressure induced by overexpression of human C-reactive_protein .
22555227	0	Rosuvastatin	0,12	C-reactive_protein	37,55	Rosuvastatin	C-reactive protein	MESH:C422923	1401	Chemical	Gene	have|nsubj|START_ENTITY have|dobj|effect effect|nmod|END_ENTITY	Rosuvastatin might have an effect on C-reactive_protein but not on rheumatoid_disease activity : Tayside randomized controlled study .
24410968	0	Rosuvastatin	0,12	C-reactive_protein	68,86	Rosuvastatin	C-reactive protein	MESH:C422923	1401	Chemical	Gene	block|nsubj|START_ENTITY block|dobj|actions actions|nmod|END_ENTITY	Rosuvastatin can block pro-inflammatory actions of transgenic human C-reactive_protein without reducing its circulating levels .
25536316	0	Rosuvastatin	0,12	C-reactive_protein	144,162	Rosuvastatin	C-reactive protein	MESH:C422923	1401	Chemical	Gene	ameliorates|nsubj|START_ENTITY ameliorates|xcomp|expressing expressing|dobj|END_ENTITY	Rosuvastatin ameliorates inflammation , renal fat accumulation , and kidney_injury in transgenic spontaneously hypertensive rats expressing human C-reactive_protein .
22360448	0	Rosuvastatin	0,12	CYP2C11	45,52	Rosuvastatin	CYP2C11	MESH:C422923	29277(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	Rosuvastatin suppresses the liver microsomal CYP2C11 and CYP2C6 expression in male Wistar_rats .
12481202	0	Rosuvastatin	0,12	HMG-CoA_reductase	37,54	Rosuvastatin	HMG-CoA reductase	MESH:C422923	3156	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Rosuvastatin : a highly effective new HMG-CoA_reductase inhibitor .
16128507	0	Rosuvastatin	0,12	HMG-CoA_reductase	29,46	Rosuvastatin	HMG-CoA reductase	MESH:C422923	3156	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Rosuvastatin : a high-potency HMG-CoA_reductase inhibitor .
15030249	0	Rosuvastatin	0,12	HMG-coA_reductase	33,50	Rosuvastatin	HMG-coA reductase	MESH:C422923	3156	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	Rosuvastatin : a new inhibitor of HMG-coA_reductase for the treatment of dyslipidemia .
19766896	0	Rosuvastatin	0,12	MMP-2	22,27	Rosuvastatin	MMP-2	MESH:C422923	17390(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Rosuvastatin inhibits MMP-2 expression and limits the progression of atherosclerosis in LDLR-deficient mice .
15135256	0	Rosuvastatin	0,12	MMP-7	21,26	Rosuvastatin	MMP-7	MESH:C422923	4316	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|secretion secretion|compound|END_ENTITY	Rosuvastatin reduces MMP-7 secretion by human_monocyte-derived_macrophages : potential relevance to atherosclerotic_plaque stability .
25740896	0	Rosuvastatin	14,26	OATP	73,77	Rosuvastatin	OATP	MESH:C422923	6579	Chemical	Gene	Evaluation|nmod|START_ENTITY Evaluation|appos|END_ENTITY	Evaluation of Rosuvastatin as an Organic Anion Transporting Polypeptide -LRB- OATP -RRB- Probe Substrate : In Vitro Transport and In Vivo Disposition in Cynomolgus_Monkeys .
23802433	0	Rosuvastatin	0,12	TGF-beta1	22,31	Rosuvastatin	TGF-beta1	MESH:C422923	59086(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Rosuvastatin inhibits TGF-beta1 expression and alleviates myocardial_fibrosis in diabetic rats .
24854110	0	Rosuvastatin	0,12	TIMP-2	22,28	Rosuvastatin	TIMP-2	MESH:C422923	7077	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Rosuvastatin inhibits TIMP-2 and promotes myocardial_angiogenesis .
18702965	0	Rosuvastatin	248,260	apolipoprotein_B	47,63	Rosuvastatin	apolipoprotein B	MESH:C422923	338	Chemical	Gene	Reductions|nmod|START_ENTITY trial|dep|Reductions relationship|dep|trial relationship|nmod|cholesterol cholesterol|compound|END_ENTITY	Statin therapy alters the relationship between apolipoprotein_B and low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol targets in high-risk patients : the MERCURY II -LRB- Measuring Effective Reductions in Cholesterol Using Rosuvastatin -RRB- trial .
15519759	0	Rosuvastatin	0,12	caspase-3	21,30	Rosuvastatin	caspase-3	MESH:C422923	836	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|activity activity|amod|END_ENTITY	Rosuvastatin reduces caspase-3 activity and up-regulates alpha-secretase in human neuroblastoma SH-SY5Y cells exposed to A_beta .
19691613	0	Rosuvastatin	0,12	insulin	57,64	Rosuvastatin	insulin	MESH:C422923	3630	Chemical	Gene	treatment|compound|START_ENTITY associated|nsubjpass|treatment associated|nmod|increase increase|nmod|resistance resistance|compound|END_ENTITY	Rosuvastatin treatment is associated with an increase in insulin resistance in hyperlipidaemic patients with impaired_fasting_glucose .
22999910	0	Rosuvastatin	0,12	interleukin-6	52,65	Rosuvastatin	interleukin-6	MESH:C422923	3569	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Rosuvastatin inhibits spontaneous and IL-1b-induced interleukin-6 production from human cultured osteoblastic cells .
8833408	0	Rotenone	0,8	CD13	91,95	Rotenone	CD13	MESH:D012402	290	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Rotenone , a mitochondrial NADH dehydrogenase inhibitor , induces cell surface expression of CD13 and CD38 and apoptosis in HL-60 cells .
25304210	0	Rotenone	0,8	S6K1_and_4E-BP1	63,78	Rotenone	S6K1 and 4E-BP1	MESH:D012402	83840;116636	Chemical	Gene	Induction|compound|START_ENTITY Induction|nmod|END_ENTITY	Rotenone Induction of Hydrogen_Peroxide Inhibits mTOR-mediated S6K1_and_4E-BP1 / eIF4E Pathways , Leading to Neuronal Apoptosis .
22094225	0	Rotenone	0,8	gp91phox	78,86	Rotenone	gp91phox	MESH:D012402	1536	Chemical	Gene	activates|nsubj|START_ENTITY activates|nmod|END_ENTITY	Rotenone activates phagocyte NADPH oxidase by binding to its membrane subunit gp91phox .
22895566	0	Rotenone	0,8	tyrosine_hydroxylase	90,110	Rotenone	tyrosine hydroxylase	MESH:D012402	25085(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|expression expression|nmod|END_ENTITY	Rotenone induces KATP channel opening in PC12 cells in association with the expression of tyrosine_hydroxylase .
21971413	0	Rottlerin	0,9	COX-2	33,38	Rottlerin	COX-2	MESH:C085746	5743	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Rottlerin enhances IL-1b-induced COX-2 expression through sustained p38 MAPK activation in MDA-MB-231 human breast_cancer cells .
15531913	0	Rottlerin	0,9	Cdc2	78,82	Rottlerin	Cdc2	MESH:C085746	983	Chemical	Gene	sensitizes|nsubj|START_ENTITY sensitizes|nmod|inhibition inhibition|nmod|END_ENTITY	Rottlerin sensitizes glioma cells to TRAIL-induced apoptosis by inhibition of Cdc2 and the subsequent downregulation of survivin and XIAP .
12859677	0	Rottlerin	0,9	PKCdelta	50,58	Rottlerin	PKCdelta	MESH:C085746	5580	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|protein_kinase_Cdelta protein_kinase_Cdelta|appos|END_ENTITY	Rottlerin , an inhibitor of protein_kinase_Cdelta -LRB- PKCdelta -RRB- , inhibits astrocytic glutamate transport activity and reduces GLAST immunoreactivity by a mechanism that appears to be PKCdelta-independent .
17692392	0	Rottlerin	0,9	PKCdelta	57,65	Rottlerin	PKCdelta	MESH:C085746	5580	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	Rottlerin : an inappropriate and ineffective inhibitor of PKCdelta .
19925787	8	Rottlerin	1123,1132	TTP	1148,1151	Rottlerin	TTP	MESH:C085746	7538	Chemical	Gene	decreased|nsubj|START_ENTITY decreased|dobj|expression expression|compound|END_ENTITY	Rottlerin also decreased TTP expression in wild type cells but not in cells in which PKCdelta had been downregulated by siRNA .
11880333	0	Rottlerin	0,9	TonEBP	63,69	Rottlerin	TonEBP	MESH:C085746	307820(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Rottlerin inhibits tonicity-dependent expression and action of TonEBP in a PKCdelta-independent fashion .
25661734	0	Rottlerin	71,80	mTORC1	28,34	Rottlerin	mTORC1	MESH:C085746	382056(Tax:10090)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|END_ENTITY	Phosphorylation-independent mTORC1 inhibition by the autophagy inducer Rottlerin .
12859677	0	Rottlerin	0,9	protein_kinase_Cdelta	27,48	Rottlerin	protein kinase Cdelta	MESH:C085746	5580	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Rottlerin , an inhibitor of protein_kinase_Cdelta -LRB- PKCdelta -RRB- , inhibits astrocytic glutamate transport activity and reduces GLAST immunoreactivity by a mechanism that appears to be PKCdelta-independent .
2795828	0	Routine	0,7	prothrombin	19,30	Routine	prothrombin	null	2147	Chemical	Gene	use|nsubj|START_ENTITY use|nmod|END_ENTITY	Routine use of the prothrombin and partial thromboplastin times .
14503989	0	Routine	0,7	transferrin	8,19	Routine	transferrin	null	7018	Chemical	Gene	measurement|amod|START_ENTITY measurement|compound|END_ENTITY	Routine transferrin saturation measurement in liver clinic patients increases detection of hereditary haemochromatosis .
12850842	0	Roxifiban	48,57	P-selectin	61,71	Roxifiban	P-selectin	MESH:C118235	6403	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effects of the glycoprotein IIb/IIIa antagonist Roxifiban on P-selectin expression , fibrinogen binding , and microaggregate formation in a phase I dose-finding study : no evidence for platelet activation during treatment with a glycoprotein IIb/IIIa antagonist .
8118677	8	Roxindole	1171,1180	5-HT1A	1184,1190	Roxindole	5-HT1A	MESH:C059613	24473(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Roxindole , a 5-HT1A agonist and 5-HT uptake inhibitor , was the most potent serotonergic compound tested .
17199791	0	Roxithromycin	0,13	transforming_growth_factor-beta	23,54	Roxithromycin	transforming growth factor-beta	MESH:D015575	7040	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Roxithromycin inhibits transforming_growth_factor-beta production by cultured human mesangial cells .
24810170	0	RpoS	13,17	Rrp2	70,74	RpoS	Rrp2	null	54933	Chemical	Gene	Synthesis|nmod|START_ENTITY END_ENTITY|nsubj|Synthesis	Synthesis of RpoS is dependent on a putative enhancer binding protein Rrp2 in Borrelia_burgdorferi .
23423687	0	Rs143383	0,8	growth_differentiation_factor_5	16,47	Rs143383	growth differentiation factor 5	null	8200	Chemical	Gene	START_ENTITY|nmod|gene gene|amod|END_ENTITY	Rs143383 in the growth_differentiation_factor_5 -LRB- GDF5 -RRB- gene significantly associated with osteoarthritis -LRB- OA -RRB- - a comprehensive meta-analysis .
24002895	0	Rs290487	0,8	TCF7L2	12,18	Rs290487	TCF7L2	null	6934	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Rs290487 of TCF7L2 gene is not associated with type 2 diabetes in Chinese Han population : a case control study and meta-analysis .
23431394	0	Rs4074134	0,9	BDNF	15,19	Rs4074134	BDNF	null	627	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Rs4074134 near BDNF gene is associated with type_2_diabetes_mellitus in Chinese Han population independently of body mass index .
26248074	0	Ru360	43,48	UCP2	0,4	Ru360	UCP2	MESH:C112020	22228(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|compound|END_ENTITY	UCP2 Modulates Cardioprotective Effects of Ru360 in Isolated Cardiomyocytes during Ischemia .
26248074	0	Ru360	43,48	UCP2	0,4	Ru360	UCP2	MESH:C112020	22228(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|compound|END_ENTITY	UCP2 Modulates Cardioprotective Effects of Ru360 in Isolated Cardiomyocytes during Ischemia .
19929710	0	Ruboxistaurin	0,13	PKC-beta	15,23	Ruboxistaurin	PKC-beta	MESH:C099154	5579	Chemical	Gene	START_ENTITY|dep|inhibition inhibition|amod|END_ENTITY	Ruboxistaurin : PKC-beta inhibition for complications of diabetes .
19825373	0	Ruboxistaurin	0,13	PKCbeta	17,24	Ruboxistaurin	PKCbeta	MESH:C099154	18751(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Ruboxistaurin , a PKCbeta inhibitor , inhibits retinal_neovascularization via suppression of phosphorylation of ERK1/2 and Akt .
20028386	0	Rubratoxin_A	0,12	phosphatase_2A	56,70	Rubratoxin A	phosphatase 2A	null	51792(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Rubratoxin_A specifically and potently inhibits protein phosphatase_2A and suppresses cancer metastasis .
25060908	0	Rutin	0,5	ASC	16,19	Rutin	ASC	MESH:D012431	282817(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|compound|END_ENTITY	Rutin modulates ASC expression in NLRP3 inflammasome : a study in alcohol and cerulein-induced rat model of pancreatitis .
24875145	0	Rutin	0,5	COX-2	51,56	Rutin	COX-2	MESH:D012431	19225(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Rutin inhibits UVB radiation-induced expression of COX-2 and iNOS in hairless mouse skin : p38 MAP kinase and JNK as potential targets .
25084483	0	Rutin	0,5	aldehyde_dehydrogenase_2	91,115	Rutin	aldehyde dehydrogenase 2	MESH:D012431	217	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|nmod|END_ENTITY	Rutin attenuates ethanol-induced neurotoxicity in hippocampal neuronal cells by increasing aldehyde_dehydrogenase_2 .
21919691	0	Ruxolitinib	0,11	JAK1/2	19,25	Ruxolitinib	JAK1/2	MESH:C540383	3716;3717	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Ruxolitinib : a new JAK1/2 inhibitor that offers promising options for treatment of myelofibrosis .
25197973	0	Ruxolitinib	31,42	c-Src	0,5	Ruxolitinib	c-Src	MESH:C540383	6714	Chemical	Gene	START_ENTITY|nsubj|binds binds|amod|END_ENTITY	c-Src binds to the cancer drug Ruxolitinib with an active conformation .
24104877	0	Ryanodine	0,9	CaMKII	47,53	Ryanodine	CaMKII	MESH:D012433	108058(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Ryanodine receptor phosphorylation by oxidized CaMKII contributes to the cardiotoxic effects of cardiac glycosides .
26432489	0	Ryanodine	0,9	CaMKII	38,44	Ryanodine	CaMKII	MESH:D012433	12323(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Ryanodine receptor phosphorylation by CaMKII promotes spontaneous Ca -LRB- 2 + -RRB- release events in a rodent model of early stage diabetes : The arrhythmogenic substrate .
18283481	0	Ryanodine	0,9	RyR1	27,31	Ryanodine	RyR1	MESH:D012433	6261	Chemical	Gene	receptor|amod|START_ENTITY receptor|dep|expression expression|appos|END_ENTITY	Ryanodine receptor type-1 -LRB- RyR1 -RRB- expression and protein S-nitrosylation pattern in human soleus myofibres following bed rest and exercise countermeasure .
19802526	0	Ryanodine	0,9	RyR1	26,30	Ryanodine	RyR1	MESH:D012433	6261	Chemical	Gene	modification|amod|START_ENTITY modification|nmod|END_ENTITY	Ryanodine modification of RyR1 retrogradely affects L-type Ca -LRB- 2 + -RRB- channel gating in skeletal muscle .
22427320	0	Ryanodine	0,9	S2808	19,24	Ryanodine	S2808	MESH:D012433	1079073(Tax:198215)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|compound|END_ENTITY	Ryanodine receptor S2808 phosphorylation in heart_failure : smoking gun or red herring .
11507100	0	Ryanodine	0,9	ryanodine_receptor	49,67	Ryanodine	ryanodine receptor	MESH:D012433	6262	Chemical	Gene	sensitizes|nsubj|START_ENTITY sensitizes|dobj|channel channel|appos|END_ENTITY	Ryanodine sensitizes the Ca -LRB- 2 + -RRB- release channel -LRB- ryanodine_receptor -RRB- to Ca -LRB- 2 + -RRB- activation .
14600402	0	S-40503	25,32	androgen_receptor	65,82	S-40503	androgen receptor	MESH:C540747	24208(Tax:10116)	Chemical	Gene	START_ENTITY|appos|modulator modulator|compound|END_ENTITY	Bone anabolic effects of S-40503 , a novel nonsteroidal selective androgen_receptor modulator -LRB- SARM -RRB- , in rat models of osteoporosis .
22430536	0	S-40542	27,34	androgen_receptor	68,85	S-40542	androgen receptor	null	367	Chemical	Gene	START_ENTITY|appos|modulator modulator|compound|END_ENTITY	Anti-androgenic effects of S-40542 , a novel non-steroidal selective androgen_receptor modulator -LRB- SARM -RRB- for the treatment of benign_prostatic_hyperplasia .
25721168	0	S-777469	0,8	Cannabinoid_Type_2_Receptor	18,45	S-777469	Cannabinoid Type 2 Receptor	MESH:C574957	12802(Tax:10090)	Chemical	Gene	START_ENTITY|appos|Agonist Agonist|compound|END_ENTITY	S-777469 , a Novel Cannabinoid_Type_2_Receptor Agonist , Suppresses Itch-Associated Scratching Behavior in Rodents through Inhibition of Itch Signal Transmission .
23763649	0	S-777469	77,85	cannabinoid_receptor_2	93,115	S-777469	cannabinoid receptor 2	MESH:C574957	57302(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Non-clinical evaluation of the metabolism , pharmacokinetics and excretion of S-777469 , a new cannabinoid_receptor_2 selective agonist .
17470645	0	S-8921	118,124	apical_sodium-dependent_bile_acid_transporter	138,183	S-8921	apical sodium-dependent bile acid transporter	MESH:C106517	29500(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|amod|END_ENTITY	Glucuronidation converting methyl_1 - -LRB- 3,4-dimethoxyphenyl -RRB- -3 - -LRB- 3-ethylvaleryl -RRB- -4 - hydroxy-6 ,7,8 - trimethoxy-2-naphthoate -LRB- S-8921 -RRB- to a potent apical_sodium-dependent_bile_acid_transporter inhibitor , resulting in a hypocholesterolemic action .
2559190	0	S-9780	38,44	ACE	23,26	S-9780	ACE	MESH:C053500	1636	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Pharmacokinetics of an ACE inhibitor , S-9780 , in man : evidence of tissue binding .
25338671	0	S-Adenosylmethionine	0,20	b-catenin	53,62	S-Adenosylmethionine	b-catenin	MESH:D012436	1499	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|END_ENTITY	S-Adenosylmethionine and methylthioadenosine inhibit b-catenin signaling by multiple mechanisms in liver and colon_cancer .
9056390	0	S-Methylthiocitrulline	0,22	nitric_oxide_synthase	35,56	S-Methylthiocitrulline	nitric oxide synthase	MESH:C086717	4843	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	S-Methylthiocitrulline , a neuronal nitric_oxide_synthase inhibitor , protects against malonate and MPTP neurotoxicity .
27064847	0	S-Nitrosoglutathione	73,93	GSNOR	105,110	S-Nitrosoglutathione	GSNOR	MESH:D026422	128	Chemical	Gene	Reductase|compound|START_ENTITY Reductase|appos|END_ENTITY	S-Nitrosation of Conserved Cysteines Modulates Activity and Stability of S-Nitrosoglutathione Reductase -LRB- GSNOR -RRB- .
26742737	0	S-Nitrosoglutathione	11,31	MMP-1	53,58	S-Nitrosoglutathione	MMP-1	MESH:D026422	4312	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|mRNA mRNA|compound|END_ENTITY	Effects of S-Nitrosoglutathione on the Expression of MMP-1 mRNA in HT1080 Cells during Hypoxic_Hypoxia .
25774991	0	S-Oxide	38,45	Vasopressin	49,60	S-Oxide	Vasopressin	CHEBI:22063	551	Chemical	Gene	START_ENTITY|nmod|Ligands Ligands|compound|END_ENTITY	N-Benzoyl-1 ,5 - benzothiazepine and Its S-Oxide as Vasopressin Receptor Ligands : Insight into the Active Stereochemistry around the Seven-Membered Ring .
22174902	0	S-acyl	29,35	AKR1	58,62	S-acyl	AKR1	null	851857(Tax:4932)	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	The ankyrin repeats and DHHC S-acyl transferase domain of AKR1 act independently to regulate switching from vegetative to mating states in yeast .
20052680	0	S-adenosyl-L-methionine	105,128	Sp1610	46,52	S-adenosyl-L-methionine	Sp1610	CHEBI:15414	931215(Tax:170187)	Chemical	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Crystal structure of Streptococcus_pneumoniae Sp1610 , a putative tRNA methyltransferase , in complex with S-adenosyl-L-methionine .
20677792	0	S-adenosyl-L-methionine	0,23	ryanodine_receptor	50,68	S-adenosyl-L-methionine	ryanodine receptor	CHEBI:15414	6262	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	S-adenosyl-L-methionine regulation of the cardiac ryanodine_receptor involves multiple mechanisms .
21904625	0	S-adenosyl_methionine	24,45	catechol_O-methyltransferase	57,85	S-adenosyl methionine	catechol O-methyltransferase	MESH:D012436	1312	Chemical	Gene	mechanism|nmod|START_ENTITY mechanism|amod|END_ENTITY	Structural mechanism of S-adenosyl_methionine binding to catechol_O-methyltransferase .
22407595	0	S-adenosyl_methionine	0,21	ubiquitin-conjugating_enzyme_9	32,62	S-adenosyl methionine	ubiquitin-conjugating enzyme 9	MESH:D012436	22196(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	S-adenosyl_methionine regulates ubiquitin-conjugating_enzyme_9 protein expression and sumoylation in murine liver and human cancers .
6722172	0	S-adenosylhomocysteine	11,33	hydroxyindole_O-methyltransferase	37,70	S-adenosylhomocysteine	hydroxyindole O-methyltransferase	MESH:D012435	281013(Tax:9913)	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of S-adenosylhomocysteine to hydroxyindole_O-methyltransferase .
7150609	0	S-adenosylhomocysteine	56,78	valyl-tRNA_synthetase	31,52	S-adenosylhomocysteine	valyl-tRNA synthetase	MESH:D012435	7407	Chemical	Gene	mechanism|nmod|START_ENTITY mechanism|nmod|END_ENTITY	The mechanism of inhibition of valyl-tRNA_synthetase by S-adenosylhomocysteine .
22487307	0	S-adenosylmethionine	2,22	Dre2	105,109	S-adenosylmethionine	Dre2	MESH:D012436	853945(Tax:4932)	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	A S-adenosylmethionine methyltransferase-like domain within the essential , Fe-S-containing yeast protein Dre2 .
10989279	0	S-adenosylmethionine	32,52	H-ras	81,86	S-adenosylmethionine	H-ras	MESH:D012436	15461(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Insulin-mediated alterations in S-adenosylmethionine decarboxylase expression in H-ras transformed cells of varying degrees of malignancy .
18275848	0	S-adenosylmethionine	63,83	Heme_oxygenase-1	0,16	S-adenosylmethionine	Heme oxygenase-1	MESH:D012436	3162	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Heme_oxygenase-1 is a novel target and antioxidant mediator of S-adenosylmethionine .
16831604	0	S-adenosylmethionine	0,20	HuR	43,46	S-adenosylmethionine	HuR	MESH:D012436	15568(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	S-adenosylmethionine regulates cytoplasmic HuR via AMP-activated kinase .
1530659	0	S-adenosylmethionine	94,114	S-adenosylmethionine_decarboxylase	27,61	S-adenosylmethionine	S-adenosylmethionine decarboxylase	MESH:D012436	262	Chemical	Gene	analogues|amod|START_ENTITY inhibition|nmod|analogues inhibition|nmod|END_ENTITY	Irreversible inhibition of S-adenosylmethionine_decarboxylase of Trypanosoma brucei brucei by S-adenosylmethionine analogues .
15064230	0	S-adenosylmethionine	75,95	TNF-alpha	44,53	S-adenosylmethionine	TNF-alpha	MESH:D012436	7124	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Inhibition of lipopolysaccharide-stimulated TNF-alpha promoter activity by S-adenosylmethionine and 5 ' - methylthioadenosine .
22985361	0	S-adenosylmethionine	79,99	cystathionine_b-synthase	6,30	S-adenosylmethionine	cystathionine b-synthase	MESH:D012436	875	Chemical	Gene	sites|nmod|START_ENTITY classes|nmod|sites contains|dobj|classes contains|nsubj|END_ENTITY	Human cystathionine_b-synthase -LRB- CBS -RRB- contains two classes of binding sites for S-adenosylmethionine -LRB- SAM -RRB- : complex regulation of CBS activity and stability by SAM .
26803480	0	S-adenosylmethionine	85,105	cystathionine_b-synthase	40,64	S-adenosylmethionine	cystathionine b-synthase	MESH:D012436	101703797	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Low sulfide levels and a high degree of cystathionine_b-synthase -LRB- CBS -RRB- activation by S-adenosylmethionine -LRB- SAM -RRB- in the long-lived naked_mole-rat .
11555831	0	S-adenosylmethionine	6,26	methylenetetrahydrofolate_reductase	57,92	S-adenosylmethionine	methylenetetrahydrofolate reductase	MESH:D012436	4524	Chemical	Gene	concentrations|amod|START_ENTITY END_ENTITY|nsubj|concentrations	Blood S-adenosylmethionine concentrations and lymphocyte methylenetetrahydrofolate_reductase activity in diabetes_mellitus and diabetic_nephropathy .
7051769	0	S-adenosylmethionine	62,82	methylenetetrahydrofolate_reductase	14,49	S-adenosylmethionine	methylenetetrahydrofolate reductase	MESH:D012436	4524	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Modulation of methylenetetrahydrofolate_reductase activity by S-adenosylmethionine and by dihydrofolate and its polyglutamate analogues .
23661436	0	S-adenosylmethionine	0,20	tissue_inhibitor_of_metalloproteinase-2	51,90	S-adenosylmethionine	tissue inhibitor of metalloproteinase-2	MESH:D012436	7077	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	S-adenosylmethionine , a methyl donor , up regulates tissue_inhibitor_of_metalloproteinase-2 in colorectal_cancer .
9199898	0	S-allyl_cysteine	0,16	nuclear_factor_kappa_B	40,62	S-allyl cysteine	nuclear factor kappa B	MESH:C065299	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	S-allyl_cysteine inhibits activation of nuclear_factor_kappa_B in human T cells .
19157822	0	S-allylcysteine	0,15	E-cadherin	44,54	S-allylcysteine	E-cadherin	MESH:C065299	999	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	S-allylcysteine modulates the expression of E-cadherin and inhibits the malignant progression of human oral_cancer .
6644749	0	S-carbobenzoxyglutathione	0,25	glyoxalase_II	64,77	S-carbobenzoxyglutathione	glyoxalase II	MESH:C039841	3029	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	S-carbobenzoxyglutathione : a competitive inhibitor of mammalian glyoxalase_II .
8589803	0	S-fluorenylmethoxycarbonyl_glutathione	0,38	glyoxalase_II	77,90	S-fluorenylmethoxycarbonyl glutathione	glyoxalase II	MESH:C098261	3029	Chemical	Gene	START_ENTITY|dep|inhibition inhibition|nmod|END_ENTITY	S-fluorenylmethoxycarbonyl_glutathione and diesters : inhibition of mammalian glyoxalase_II .
17133316	0	S-glutathione	13,26	GSTP1	42,47	S-glutathione	GSTP1	null	2950	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	-LSB- Transferase S-glutathione class pi gene -LRB- GSTP1 -RRB- polymorphism in thyroid_cancer patients -RSB- .
23278499	0	S-glutathionylated_and_S-cysteinylated	34,72	cystatin_B	88,98	S-glutathionylated and S-cysteinylated	cystatin B	null	1476	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Top-down HPLC-ESI-MS detection of S-glutathionylated_and_S-cysteinylated derivatives of cystatin_B and its 1-53 and 54-98 fragments in whole saliva of human preterm newborns .
15363445	6	S-methylisothiourea	845,864	iNOS	829,833	S-methylisothiourea	iNOS	MESH:C027744	24599(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	The selective iNOS inhibitor , S-methylisothiourea -LRB- MTU -RRB- , suppressed hemorrhagic expression of renal iNOS mRNA and systemic NO products , suppressed the increases of serum creatinine and UN , and improved renal histological aggravations induced by hemorrhaging .
24697299	0	S-methylisothiourea	51,70	inducible_nitric_oxide_synthase	75,106	S-methylisothiourea	inducible nitric oxide synthase	MESH:C027744	100008833(Tax:9986)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Chondroprotective and anti-inflammatory effects of S-methylisothiourea , an inducible_nitric_oxide_synthase inhibitor in cartilage and synovial explants model of osteoarthritis .
8878517	0	S-methylisothiourea	0,19	inducible_nitric_oxide_synthase	29,60	S-methylisothiourea	inducible nitric oxide synthase	MESH:C027744	100008833(Tax:9986)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	S-methylisothiourea inhibits inducible_nitric_oxide_synthase and improves left ventricular performance after acute myocardial_infarction .
17895252	0	S-nitroso-L-homocysteine	65,89	dimethylarginine_dimethylaminohydrolase-1	20,61	S-nitroso-L-homocysteine	dimethylarginine dimethylaminohydrolase-1	null	23576	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of human dimethylarginine_dimethylaminohydrolase-1 by S-nitroso-L-homocysteine and hydrogen_peroxide .
2172242	0	S-nitroso-N-acetylcysteine	55,81	fibrinogen	14,24	S-nitroso-N-acetylcysteine	fibrinogen	MESH:C024940	2244	Chemical	Gene	binding|nmod|START_ENTITY binding|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of fibrinogen binding to human platelets by S-nitroso-N-acetylcysteine .
15880470	0	S-nitroso-N-acetylcysteine	31,57	iNOS	71,75	S-nitroso-N-acetylcysteine	iNOS	MESH:C024940	24599(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|compound|END_ENTITY	Addition of nitric_oxide donor S-nitroso-N-acetylcysteine to selective iNOS inhibitor 1400W further improves contractile function in reperfused skeletal muscle .
9812917	9	S-nitroso-N-acetylpenicillamine	1610,1641	PAI-1	1663,1668	S-nitroso-N-acetylpenicillamine	PAI-1	MESH:D026423	5054	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	The membrane-permeant cGMP analogue 8-Br-cGMP reduced Ang II-stimulated PAI-1 expression by 60 % , and an inhibitor of soluble guanylyl cyclase -LRB- 1H - -LSB- 1,2,4 -RSB- oxadiazolo -LSB- 4 , _ 3-a -RSB- quinoxalin-1-one -RRB- significantly impaired the inhibitory effects of S-nitroso-N-acetylpenicillamine on Ang II-stimulated PAI-1 expression .
16847746	0	S-nitrosoglutathione	0,20	CXCR4	31,36	S-nitrosoglutathione	CXCR4	MESH:D026422	7852	Chemical	Gene	modulates|amod|START_ENTITY END_ENTITY|nsubj|modulates	S-nitrosoglutathione modulates CXCR4 and ICOS expression .
17543375	0	S-nitrosoglutathione	21,41	GSNOR	53,58	S-nitrosoglutathione	GSNOR	MESH:D026422	128	Chemical	Gene	reductase|amod|START_ENTITY reductase|appos|END_ENTITY	Genetic variation in S-nitrosoglutathione reductase -LRB- GSNOR -RRB- and childhood asthma .
21543898	0	S-nitrosoglutathione	12,32	GSNOR	44,49	S-nitrosoglutathione	GSNOR	MESH:D026422	128	Chemical	Gene	reductase|amod|START_ENTITY Function|nmod|reductase Function|appos|END_ENTITY	Function of S-nitrosoglutathione reductase -LRB- GSNOR -RRB- in plant development and under biotic/abiotic stress .
26979322	0	S-nitrosoglutathione	58,78	GSNOR	90,95	S-nitrosoglutathione	GSNOR	MESH:D026422	128	Chemical	Gene	reductase|amod|START_ENTITY reductase|appos|END_ENTITY	Erratum to : Quantitative proteomics analysis reveals that S-nitrosoglutathione reductase -LRB- GSNOR -RRB- and nitric_oxide signaling enhance poplar defense against chilling stress .
11289659	0	S-nitrosoglutathione	0,20	NFkappaB	48,56	S-nitrosoglutathione	NFkappaB	MESH:D026422	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|compound|END_ENTITY	S-nitrosoglutathione inhibits TNF-alpha-induced NFkappaB activation in neutrophils .
21256830	0	S-nitrosoglutathione	24,44	carbonyl_reductases_1_and_3	54,81	S-nitrosoglutathione	carbonyl reductases 1 and 3	MESH:D026422	873;874	Chemical	Gene	Studies|nmod|START_ENTITY Studies|nmod|END_ENTITY	Studies on reduction of S-nitrosoglutathione by human carbonyl_reductases_1_and_3 .
23264628	0	S-nitrosoglutathione	0,20	ciliary_neurotrophic_factor	29,56	S-nitrosoglutathione	ciliary neurotrophic factor	MESH:D026422	1270	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	S-nitrosoglutathione induces ciliary_neurotrophic_factor expression in astrocytes , which has implications to protect the central nervous system under pathological conditions .
8536691	0	S-nitrosoglutathione	45,65	glutathione_reductase	20,41	S-nitrosoglutathione	glutathione reductase	MESH:D026422	2936	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of human glutathione_reductase by S-nitrosoglutathione .
24699383	0	S-nitrosoglutathione	0,20	inducible_nitric_oxide_synthase	30,61	S-nitrosoglutathione	inducible nitric oxide synthase	MESH:D026422	4843	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|upregulation upregulation|amod|END_ENTITY	S-nitrosoglutathione inhibits inducible_nitric_oxide_synthase upregulation by redox posttranslational modification in experimental diabetic_retinopathy .
15769744	0	S-nitrosothiols	121,136	LAT1	81,85	S-nitrosothiols	LAT1	MESH:D026403	8140	Chemical	Gene	activity|nmod|START_ENTITY role|nmod|activity role|nmod|END_ENTITY	Identification of stereoselective transporters for S-nitroso-L-cysteine : role of LAT1 and LAT2 in biological activity of S-nitrosothiols .
15967877	0	S-nitrosothiols	28,43	PTEN	20,24	S-nitrosothiols	PTEN	MESH:D026403	5728	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Redox regulation of PTEN by S-nitrosothiols .
2893612	0	S-oxalylglutathione	0,19	gamma-glutamyltransferase	39,64	S-oxalylglutathione	gamma-glutamyltransferase	MESH:C052145	728226	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	S-oxalylglutathione is a substrate for gamma-glutamyltransferase -LRB- GGT -RRB- .
2890640	0	S-sulfocysteine	87,102	gamma-glutamylcysteine_synthetase	16,49	S-sulfocysteine	gamma-glutamylcysteine synthetase	MESH:C011119	25283(Tax:10116)	Chemical	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of gamma-glutamylcysteine_synthetase , but not of glutamine synthetase , by S-sulfocysteine and S-sulfohomocysteine .
15476401	0	S-trityl-L-cysteine	48,67	Eg5	115,118	S-trityl-L-cysteine	Eg5	MESH:C003724	3832	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Identification of the protein binding region of S-trityl-L-cysteine , a new potent inhibitor of the mitotic kinesin Eg5 .
16507573	0	S-trityl-L-cysteine	0,19	Eg5	82,85	S-trityl-L-cysteine	Eg5	MESH:C003724	3832	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	S-trityl-L-cysteine is a reversible , tight binding inhibitor of the human kinesin Eg5 that specifically blocks mitotic progression .
18186019	0	S-trityl-L-cysteine	44,63	Eg5	120,123	S-trityl-L-cysteine	Eg5	MESH:C003724	3832	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Proteome analysis of apoptosis signaling by S-trityl-L-cysteine , a potent reversible inhibitor of human mitotic kinesin Eg5 .
18266314	0	S-trityl-L-cysteine	35,54	Eg5	108,111	S-trityl-L-cysteine	Eg5	MESH:C003724	3832	Chemical	Gene	relationship|nmod|START_ENTITY analogues|nsubj|relationship analogues|nmod|inhibitors inhibitors|nmod|END_ENTITY	Structure-activity relationship of S-trityl-L-cysteine analogues as inhibitors of the human mitotic kinesin Eg5 .
21344920	0	S-trityl-L-cysteine	70,89	Eg5	119,122	S-trityl-L-cysteine	Eg5	MESH:C003724	3832	Chemical	Gene	derivatives|amod|START_ENTITY relationship|nmod|derivatives relationship|nmod|inhibitors inhibitors|nmod|END_ENTITY	Structure-activity relationship and multidrug resistance study of new S-trityl-L-cysteine derivatives as inhibitors of Eg5 .
24451491	0	S-trityl-L-cysteine	54,73	Eg5	36,39	S-trityl-L-cysteine	Eg5	MESH:C003724	3832	Chemical	Gene	analogue|amod|START_ENTITY using|dobj|analogue END_ENTITY|xcomp|using	Photocontrol of the mitotic kinesin Eg5 using a novel S-trityl-L-cysteine analogue as a photochromic inhibitor .
19252308	0	S-warfarin	21,31	CYP2C9	79,85	S-warfarin	CYP2C9	null	1559	Chemical	Gene	metabolism|amod|START_ENTITY Effect|nmod|metabolism Effect|nmod|END_ENTITY	Effect of ethanol on S-warfarin and diclofenac metabolism by recombinant human CYP2C9 .1 .
20429590	0	S-warfarin	66,76	CYP2C9	45,51	S-warfarin	CYP2C9	null	1559	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|nummod|END_ENTITY	Hydroxywarfarin metabolites potently inhibit CYP2C9 metabolism of S-warfarin .
18854184	4	S1P	604,607	RGS4	621,625	S1P	RGS3	CHEBI:37550	5998	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	The mRNA expression of the S1P -LRB- 1 -RRB- receptor , RGS4 and RGS16 were down-regulated in VSMCs during phenotypic modulation induced by culturing , whereas mRNA levels of RGS2 , RGS3 , S1P -LRB- 2 -RRB- and S1P -LRB- 3 -RRB- receptors were unchanged .
18854184	4	S1P	751,754	RGS4	621,625	S1P	RGS3	CHEBI:37550	5998	Chemical	Gene	levels|nmod|START_ENTITY unchanged|nsubj|levels down-regulated|advcl|unchanged down-regulated|nsubj|expression expression|nmod|receptor receptor|appos|END_ENTITY	The mRNA expression of the S1P -LRB- 1 -RRB- receptor , RGS4 and RGS16 were down-regulated in VSMCs during phenotypic modulation induced by culturing , whereas mRNA levels of RGS2 , RGS3 , S1P -LRB- 2 -RRB- and S1P -LRB- 3 -RRB- receptors were unchanged .
21289303	7	S1P	1064,1067	pLN	1051,1054	S1P	S1P	CHEBI:37550	13609(Tax:10090)	Chemical	Gene	cells|nmod|START_ENTITY cells|compound|END_ENTITY	Transwell chemotaxis assays revealed the migration of freshly isolated splenocytes , but not pLN cells to S1P .
24776490	0	S1RA	0,4	sigma-1_receptor	18,34	S1RA	sigma-1 receptor	null	18391(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	S1RA , a selective sigma-1_receptor antagonist , inhibits inflammatory_pain in the carrageenan and complete Freund 's adjuvant models in mice .
10872560	0	S21402	48,54	neutral_endopeptidase	76,97	S21402	neutral endopeptidase	MESH:C111219	24590(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Reversal of cardiac_hypertrophy and fibrosis by S21402 , a dual inhibitor of neutral_endopeptidase and angiotensin_converting_enzyme in SHRs .
20399198	0	S23906	94,100	XPC	17,20	S23906	XPC	MESH:C560585	7508	Chemical	Gene	regulate|nmod|START_ENTITY regulate|nsubj|END_ENTITY	The NER proteins XPC and CSB , but not ERCC1 , regulate the sensitivity to the novel DNA binder S23906 : implications for recognition and repair of antitumor alkylators .
26556350	0	S23906-1	91,99	GAPDH	79,84	S23906-1	GAPDH	MESH:C436732	2597	Chemical	Gene	Groove|compound|START_ENTITY Groove|compound|END_ENTITY	Protein Recognition in Drug-Induced DNA Alkylation : When the Moonlight Protein GAPDH Meets S23906-1 / DNA Minor Groove Adducts .
24900771	0	S32826	70,76	Autotaxin	84,93	S32826	Autotaxin	MESH:C533861	5168	Chemical	Gene	phosphonic_Acid|dep|START_ENTITY phosphonic_Acid|nmod|Inhibitor Inhibitor|compound|END_ENTITY	Dendrimer Conjugate of -LSB- 4 - -LRB- Tetradecanoylamino -RRB- benzyl -RSB- phosphonic_Acid -LRB- S32826 -RRB- as an Autotaxin Inhibitor .
18755937	0	S32826	0,6	autotaxin	33,42	S32826	autotaxin	MESH:C533861	5168	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	S32826 , a nanomolar inhibitor of autotaxin : discovery , synthesis and applications as a pharmacological tool .
20663270	0	S33138	37,43	dopamine_D3_receptor	4,24	S33138	dopamine D3 receptor	MESH:C526614	29238(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	The dopamine_D3_receptor antagonist , S33138 , counters cognitive_impairment in a range of rodent and primate procedures .
21481181	0	S35972	0,6	thrombin	24,32	S35972	thrombin	MESH:C569628	29251(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	S35972 , a direct-acting thrombin inhibitor with high oral bioavailability and antithrombotic efficacy .
20520592	0	S3I-201	25,32	STAT3	8,13	S3I-201	STAT3	MESH:C520337	25125(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	A novel STAT3 inhibitor , S3I-201 , attenuates renal interstitial fibroblast activation and interstitial_fibrosis in obstructive nephropathy .
26942696	0	S3I-201	70,77	STAT3	52,57	S3I-201	STAT3	MESH:C520337	6774	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|appos|END_ENTITY	Signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- inhibitor , S3I-201 , acts as a potent and non-selective alkylating agent .
26942696	0	S3I-201	70,77	Signal_transducer_and_activator_of_transcription_3	0,50	S3I-201	Signal transducer and activator of transcription 3	MESH:C520337	6774	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- inhibitor , S3I-201 , acts as a potent and non-selective alkylating agent .
18508045	0	SA13353	0,7	TNF-alpha	81,90	SA13353	TNF-alpha	MESH:C530925	24835(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	SA13353 -LRB- 1 - -LSB- 2 - -LRB- 1-Adamantyl -RRB- ethyl -RSB- -1 - pentyl-3 - -LSB- 3 - -LRB- 4-pyridyl -RRB- propyl -RSB- urea -RRB- inhibits TNF-alpha production through the activation of capsaicin-sensitive afferent neurons mediated via transient_receptor_potential_vanilloid_1 in vivo .
18508045	0	SA13353	0,7	transient_receptor_potential_vanilloid_1	178,218	SA13353	transient receptor potential vanilloid 1	MESH:C530925	83810(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|activation activation|nmod|neurons neurons|acl|mediated mediated|nmod|END_ENTITY	SA13353 -LRB- 1 - -LSB- 2 - -LRB- 1-Adamantyl -RRB- ethyl -RSB- -1 - pentyl-3 - -LSB- 3 - -LRB- 4-pyridyl -RRB- propyl -RSB- urea -RRB- inhibits TNF-alpha production through the activation of capsaicin-sensitive afferent neurons mediated via transient_receptor_potential_vanilloid_1 in vivo .
19147859	0	SA13353	21,28	transient_receptor_potential_vanilloid_1	102,142	SA13353	transient receptor potential vanilloid 1	MESH:C530925	83810(Tax:10116)	Chemical	Gene	-LSB-|compound|START_ENTITY effect|nmod|-LSB- effect|dep|-RSB- -RSB-|appos|agonist agonist|amod|END_ENTITY	Preventive effect of SA13353 -LSB- 1 - -LSB- 2 - -LRB- 1-adamantyl -RRB- ethyl -RSB- -1 - pentyl-3 - -LSB- 3 - -LRB- 4-pyridyl -RRB- propyl -RSB- urea -RSB- , a novel transient_receptor_potential_vanilloid_1 agonist , on ischemia/reperfusion-induced renal_injury in rats .
20351486	0	SA13353	11,18	transient_receptor_potential_vanilloid_1	22,62	SA13353	transient receptor potential vanilloid 1	MESH:C530925	7442	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Effects of SA13353 , a transient_receptor_potential_vanilloid_1 agonist , on leukocyte infiltration in lipopolysaccharide-induced acute_lung_injury and ovalbumin-induced allergic_airway_inflammation .
20813108	0	SA14867	0,7	kappa-opioid_receptor	29,50	SA14867	kappa-opioid receptor	MESH:C556960	4986	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	SA14867 , a newly synthesized kappa-opioid_receptor agonist with antinociceptive and antipruritic effects .
18547721	0	SA4503	78,84	sigma-1_receptor	50,66	SA4503	sigma-1 receptor	MESH:C101789	29336(Tax:10116)	Chemical	Gene	hippocampus|advmod|START_ENTITY hippocampus|nsubj|treatment treatment|nmod|ligand ligand|nmod|chaperone chaperone|amod|END_ENTITY	Chronic treatment with a selective ligand for the sigma-1_receptor chaperone , SA4503 , up-regulates BDNF protein levels in the rat hippocampus .
24334165	0	SA4503	0,6	sigma-1_receptor	10,26	SA4503	sigma-1 receptor	MESH:C101789	18391(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	SA4503 , a sigma-1_receptor agonist , suppresses motor neuron damage in in vitro and in vivo amyotrophic lateral_sclerosis models .
24882645	0	SA4503	68,74	sigma-1_receptor	42,58	SA4503	sigma-1 receptor	MESH:C101789	18391(Tax:10090)	Chemical	Gene	-RSB-|compound|START_ENTITY agonist|appos|-RSB- agonist|amod|END_ENTITY	-LSB- Cardioprotective effect of the selective sigma-1_receptor agonist , SA4503 -RSB- .
25616094	0	SA4503	66,72	sigma-1_receptor	12,28	SA4503	sigma-1 receptor	MESH:C101789	18391(Tax:10090)	Chemical	Gene	Effect|appos|START_ENTITY Effect|nmod|agonist agonist|amod|END_ENTITY	Effect of a sigma-1_receptor agonist , cutamesine_dihydrochloride -LRB- SA4503 -RRB- , on photoreceptor cell death against light-induced damage .
11990076	0	SA4503	24,30	sigma1_receptor	44,59	SA4503	sigma1 receptor	MESH:C101789	29336(Tax:10116)	Chemical	Gene	treatment|nmod|START_ENTITY treatment|appos|agonist agonist|amod|END_ENTITY	Repeated treatment with SA4503 , a selective sigma1_receptor agonist , up-regulates alpha-adrenergic system .
9203561	0	SA4503	0,6	sigma1_receptor	40,55	SA4503	sigma1 receptor	MESH:C101789	18391(Tax:10090)	Chemical	Gene	START_ENTITY|appos|enhancer enhancer|nmod|properties properties|amod|END_ENTITY	SA4503 , a novel cognitive enhancer with sigma1_receptor agonist properties , facilitates NMDA receptor-dependent learning in mice .
9544798	0	SA4503	10,16	sigma1_receptor	26,41	SA4503	sigma1 receptor	MESH:C101789	29336(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Effect of SA4503 , a novel sigma1_receptor agonist , against glutamate neurotoxicity in cultured rat retinal neurons .
12409992	0	SA4503	39,45	sigma_1_receptor	59,75	SA4503	sigma 1 receptor	MESH:C101789	29336(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	A potential antidepressant activity of SA4503 , a selective sigma_1_receptor agonist .
8858982	0	SA4503	40,46	sigma_1_receptor	56,72	SA4503	sigma 1 receptor	MESH:C101789	29336(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Enhancement of acetylcholine release by SA4503 , a novel sigma_1_receptor agonist , in the rat brain .
8960858	0	SA4503	23,29	sigma_1_receptor	39,55	SA4503	sigma 1 receptor	MESH:C101789	29336(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Ameliorating effect of SA4503 , a novel sigma_1_receptor agonist , on memory_impairments induced by cholinergic_dysfunction in rats .
9062689	0	SA4503	0,6	sigma_1_receptor	41,57	SA4503	sigma 1 receptor	MESH:C101789	29336(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|properties properties|amod|END_ENTITY	SA4503 , a novel cognitive enhancer , with sigma_1_receptor agonistic properties .
10919359	0	SA7060	11,17	neutral_endopeptidase	45,66	SA7060	neutral endopeptidase	MESH:C417988	24590(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|inhibitor inhibitor|nmod|END_ENTITY	Effects of SA7060 , a novel dual inhibitor of neutral_endopeptidase and angiotensin-converting_enzyme , on deoxycorticosterone_acetate-salt-induced hypertension in rats .
23819448	0	SAGA	35,39	Sgf73	18,23	SAGA	Sgf73	null	852814(Tax:4932)	Chemical	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	C-terminus of the Sgf73 subunit of SAGA and SLIK is important for retention in the larger complex and for heterochromatin boundary function .
23916482	6	SAHA	1013,1017	Bdnf	995,999	SAHA	Bdnf	null	24225(Tax:10116)	Chemical	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	Bdnf induction by SAHA and MS-275 at 24 h was sensitive to protein synthesis inhibition , suggesting that delayed Bdnf induction by HDAC inhibitors is secondary to changed expression of its regulators .
26493999	0	SAHA	0,4	HDAC	9,13	SAHA	HDAC	null	9734	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	SAHA , an HDAC inhibitor , overcomes erlotinib resistance in human pancreatic_cancer cells by modulating E-cadherin .
15547724	0	SAM486A	72,79	S-adenosylmethionine_decarboxylase	27,61	SAM486A	S-adenosylmethionine decarboxylase	MESH:C082408	262	Chemical	Gene	START_ENTITY|nsubj|activity activity|nmod|inhibitor inhibitor|amod|END_ENTITY	Biological activity of the S-adenosylmethionine_decarboxylase inhibitor SAM486A in human breast_cancer cells in vitro and in vivo .
17351104	0	SAR150640	186,195	beta3-adrenoceptor	231,249	SAR150640	beta3-adrenoceptor	MESH:C521336	155	Chemical	Gene	cyclohexyl|appos|START_ENTITY agonist|nmod|cyclohexyl agonist|nsubj|END_ENTITY	In vitro and in vivo pharmacological characterization of ethyl-4 - -LSB- trans-4 - -LSB- -LRB- -LRB- 2S -RRB- -2 - hydroxy-3 - -LSB- 4-hydroxy-3 -LSB- -LRB- methylsulfonyl -RRB- amino -RSB- - phenoxy -RSB- propyl -RRB- _ amino -RSB- cyclohexyl -RSB- benzoate_hydrochloride -LRB- SAR150640 -RRB- , a new potent and selective human beta3-adrenoceptor agonist for the treatment of preterm_labor .
20136828	0	SAR150640	0,9	beta3-adrenoceptor	23,41	SAR150640	beta3-adrenoceptor	MESH:C521336	155	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	SAR150640 , a selective beta3-adrenoceptor agonist , prevents human myometrial remodelling and activation of matrix metalloproteinase in an in vitro model of chorioamnionitis .
24023523	0	SAR3419	52,59	CD19	10,14	SAR3419	CD19	MESH:C569646	930	Chemical	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Targeting CD19 in B-cell_lymphoma : emerging role of SAR3419 .
26475335	0	SAR405838	0,9	MDM2	47,51	SAR405838	MDM2	MESH:C000593797	4193	Chemical	Gene	START_ENTITY|dep|Inhibitor Inhibitor|nmod|END_ENTITY	SAR405838 : A Novel and Potent Inhibitor of the MDM2 : p53 Axis for the Treatment of Dedifferentiated_Liposarcoma .
23215542	0	SAR_1118	72,80	LFA-1	41,46	SAR 1118	LFA-1	MESH:C575157	16408(Tax:10090)	Chemical	Gene	lifitegrast|appos|START_ENTITY antagonist|appos|lifitegrast antagonist|compound|END_ENTITY	Corneal_inflammation is inhibited by the LFA-1 antagonist , lifitegrast -LRB- SAR_1118 -RRB- .
23256487	0	SAR_1118	66,74	LFA-1	79,84	SAR 1118	LFA-1	MESH:C575157	3683	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Development of sustained-release microspheres for the delivery of SAR_1118 , an LFA-1 antagonist intended for the treatment of vascular_complications_of_the_eye .
24900456	0	SAR_1118	60,68	LFA-1	36,41	SAR 1118	LFA-1	MESH:C575157	3683	Chemical	Gene	Discovery|dep|START_ENTITY Discovery|nmod|END_ENTITY	Discovery and Development of Potent LFA-1 / ICAM-1 Antagonist SAR_1118 as an Ophthalmic Solution for Treating Dry_Eye .
20334535	0	SAR_1118	112,120	lymphocyte_function-associated_antigen-1	39,79	SAR 1118	lymphocyte function-associated antigen-1	MESH:C575157	3683	Chemical	Gene	Safety|appos|START_ENTITY Safety|nmod|solution solution|amod|END_ENTITY	Safety and pharmacokinetics of a novel lymphocyte_function-associated_antigen-1 antagonist ophthalmic solution -LRB- SAR_1118 -RRB- in healthy adults .
22538219	0	SAR_1118	53,61	lymphocyte_function-associated_antigen-1	85,125	SAR 1118	lymphocyte function-associated antigen-1	MESH:C575157	3683	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|nmod|END_ENTITY	Safety , tolerability , and bioavailability of topical SAR_1118 , a novel antagonist of lymphocyte_function-associated_antigen-1 : a phase 1b study .
22745733	0	SB-216763	45,54	GSK3	28,32	SB-216763	GSK3	MESH:C417521	56637(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Glycogen synthase kinase 3 -LRB- GSK3 -RRB- inhibitor , SB-216763 , promotes pluripotency in mouse embryonic stem cells .
23302485	0	SB-216763	104,113	glycogen_synthase_kinase_3b	12,39	SB-216763	glycogen synthase kinase 3b	MESH:C417521	84027(Tax:10116)	Chemical	Gene	overexpression|nmod|START_ENTITY overexpression|amod|END_ENTITY	-LSB- Effects of glycogen_synthase_kinase_3b overexpression in rat and glycogen_synthase_kinase_3b inhibitor SB-216763 on proliferation of hepatic oval cells -RSB- .
9776361	0	SB-224289	0,9	5-HT1B	37,43	SB-224289	5-HT1D	MESH:C108518	3352	Chemical	Gene	START_ENTITY|dep|antagonist antagonist|amod|END_ENTITY	SB-224289 -- a novel selective -LRB- human -RRB- 5-HT1B receptor antagonist with negative intrinsic activity .
10961381	0	SB-236057-A	14,25	5-HT1B_receptor	39,54	SB-236057-A	5-HT1B receptor	null	100135543(Tax:10141)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	The effect of SB-236057-A , a selective 5-HT1B_receptor inverse agonist , on in vivo extracellular 5-HT levels in the freely-moving guinea-pig .
11958561	0	SB-242235	0,9	p38	36,39	SB-242235	p38	MESH:C403289	81649(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|kinase kinase|amod|END_ENTITY	SB-242235 , a selective inhibitor of p38 mitogen-activated protein kinase .
11958562	0	SB-242235	0,9	p38	36,39	SB-242235	p38	MESH:C403289	1432	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|kinase kinase|amod|END_ENTITY	SB-242235 , a selective inhibitor of p38 mitogen-activated protein kinase .
19207271	0	SB-277011	32,41	dopamine_D3_receptor	55,75	SB-277011	dopamine D3 receptor	MESH:C409982	29238(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Delay of ejaculation induced by SB-277011 , a selective dopamine_D3_receptor antagonist , in the rat .
16737693	0	SB-366791	18,27	TRPV1	0,5	SB-366791	TRPV1	MESH:C477659	83810(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|nummod|END_ENTITY	TRPV1 antagonist , SB-366791 , inhibits glutamatergic synaptic transmission in rat spinal dorsal horn following peripheral inflammation .
24661104	0	SB-3CT	16,22	MMP-9	0,5	SB-3CT	MMP-9	MESH:C429533	81687(Tax:10116)	Chemical	Gene	attenuates|compound|START_ENTITY attenuates|compound|END_ENTITY	MMP-9 inhibitor SB-3CT attenuates behavioral_impairments and hippocampal_loss after traumatic brain_injury in rat .
21042762	0	SB-431542	50,59	Transforming_growth_factor_b	0,28	SB-431542	Transforming growth factor b	MESH:C459179	7040	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Transforming_growth_factor_b signaling inhibitor , SB-431542 , induces maturation of dendritic cells and enhances anti-tumor activity .
17347064	0	SB-553484	90,99	cathepsin_K	67,78	SB-553484	cathepsin K	MESH:C524569	13038(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Changes in micro-CT 3D bone parameters reflect effects of a potent cathepsin_K inhibitor -LRB- SB-553484 -RRB- on bone resorption and cortical bone formation in ovariectomized mice .
19361586	0	SB-553484	47,56	cathepsin_K	24,35	SB-553484	cathepsin K	MESH:C524569	608843(Tax:9615)	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|END_ENTITY	Protective effects of a cathepsin_K inhibitor , SB-553484 , in the canine partial medial meniscectomy model of osteoarthritis .
17145850	0	SB-590885	106,115	BRAF	77,81	SB-590885	BRAF	MESH:C508204	673	Chemical	Gene	expressing|nmod|START_ENTITY expressing|dobj|END_ENTITY	Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885 .
16797584	0	SB-611812	27,36	Urotensin-II	0,12	SB-611812	Urotensin-II	MESH:C513816	29180(Tax:10116)	Chemical	Gene	blockade|nmod|START_ENTITY blockade|amod|END_ENTITY	Urotensin-II blockade with SB-611812 attenuates cardiac_dysfunction in a rat model of coronary artery ligation .
16919371	0	SB-611812	36,45	Urotensin-II_receptor	0,21	SB-611812	Urotensin-II receptor	MESH:C513816	57305(Tax:10116)	Chemical	Gene	blockade|nmod|START_ENTITY blockade|amod|END_ENTITY	Urotensin-II_receptor blockade with SB-611812 attenuates cardiac remodeling in experimental ischemic_heart_disease .
16546225	0	SB-616234-A	0,11	5-HT1B	200,206	SB-616234-A	5-HT1B	MESH:C513705	25075(Tax:10116)	Chemical	Gene	START_ENTITY|dep|antagonist antagonist|amod|END_ENTITY	SB-616234-A -LRB- 1 - -LSB- 6 - -LRB- cis-3 ,5 - dimethylpiperazin-1-yl -RRB- -2,3 - dihydro-5-methoxyindol-1-yl -RSB- -1 - -LSB- 2 ` methyl-4 ' - -LRB- 5-methyl-1 ,2,3 - oxadiazol-3-yl -RRB- biphenyl-4-yl -RSB- methanone_hydrochloride -RRB- : a novel , potent and selective 5-HT1B receptor antagonist .
21426372	0	SB-656933	0,9	CXCR2	19,24	SB-656933	CXCR2	MESH:C568923	3579	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	SB-656933 , a novel CXCR2 selective antagonist , inhibits ex vivo neutrophil activation and ozone-induced airway_inflammation in humans .
16580202	0	SB-705498	13,22	TRPV1	68,73	SB-705498	TRPV1	MESH:C512301	7442	Chemical	Gene	Discovery|nmod|START_ENTITY Discovery|dep|antagonist antagonist|compound|END_ENTITY	Discovery of SB-705498 : a potent , selective and orally bioavailable TRPV1 antagonist suitable for clinical development .
17659837	0	SB-705498	36,45	TRPV1	49,54	SB-705498	TRPV1	MESH:C512301	7442	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activity activity|nummod|END_ENTITY	The effects of the TRPV1 antagonist SB-705498 on TRPV1 receptor-mediated activity and inflammatory hyperalgesia in humans .
22320181	0	SB-705498	64,73	TRPV1	45,50	SB-705498	TRPV1	MESH:C512301	100135466(Tax:10141)	Chemical	Gene	Inhibition|dep|START_ENTITY Inhibition|nmod|hyper-responsiveness hyper-responsiveness|nmod|antagonists antagonists|nummod|END_ENTITY	Inhibition of airway hyper-responsiveness by TRPV1 antagonists -LRB- SB-705498 and PF-04065463 -RRB- in the unanaesthetized , ovalbumin-sensitized guinea_pig .
23735181	0	SB-705498	35,44	TRPV1	17,22	SB-705498	TRPV1	MESH:C512301	7442	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|END_ENTITY	The effects of a TRPV1 antagonist , SB-705498 , in the treatment of seasonal_allergic_rhinitis .
23909699	0	SB-705498	57,66	TRPV1	70,75	SB-705498	TRPV1	MESH:C512301	7442	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Inhibition of capsaicin-driven nasal hyper-reactivity by SB-705498 , a TRPV1 antagonist .
12359626	0	SB-710411	36,45	urotensin-II	111,123	SB-710411	urotensin-II	MESH:C473646	10911	Chemical	Gene	START_ENTITY|appos|receptor receptor|compound|END_ENTITY	Pharmacological characterization of SB-710411 -LRB- Cpa-c -LSB- D-Cys-Pal-D-Trp-Lys-Val-Cys -RSB- - Cpa-amide -RRB- , a novel peptidic urotensin-II receptor antagonist .
15178353	0	SB-710411	75,84	urotensin-II	55,67	SB-710411	urotensin-II	MESH:C473646	29180(Tax:10116)	Chemical	Gene	ligand|dobj|START_ENTITY ligand|nsubj|agonistic agonistic|nmod|END_ENTITY	Differential agonistic and antagonistic effects of the urotensin-II ligand SB-710411 at rodent and primate UT receptors .
18634850	0	SB-750364	10,19	TRPV1	32,37	SB-750364	TRPV1	null	7442	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Effect of SB-750364 , a specific TRPV1 receptor antagonist , on injury-induced ectopic_discharge_in_the_lingual_nerve .
22527961	0	SB1518	84,90	FLT3	178,182	SB1518	FLT3	MESH:C561234	2322	Chemical	Gene	discovery|nmod|START_ENTITY discovery|appos|inhibitors inhibitors|nmod|Janus_kinase_2 Janus_kinase_2|appos|END_ENTITY	Structure-based design of oxygen-linked macrocyclic kinase inhibitors : discovery of SB1518 and SB1578 , potent inhibitors of Janus_kinase_2 -LRB- JAK2 -RRB- and Fms-like_tyrosine_kinase-3 -LRB- FLT3 -RRB- .
21691275	0	SB1518	0,6	JAK2	45,49	SB1518	JAK2	MESH:C561234	3717	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	SB1518 , a novel macrocyclic pyrimidine-based JAK2 inhibitor for the treatment of myeloid and lymphoid_malignancies .
22527961	0	SB1518	84,90	JAK2	140,144	SB1518	JAK2	MESH:C561234	3717	Chemical	Gene	discovery|nmod|START_ENTITY discovery|appos|inhibitors inhibitors|nmod|Janus_kinase_2 Janus_kinase_2|appos|END_ENTITY	Structure-based design of oxygen-linked macrocyclic kinase inhibitors : discovery of SB1518 and SB1578 , potent inhibitors of Janus_kinase_2 -LRB- JAK2 -RRB- and Fms-like_tyrosine_kinase-3 -LRB- FLT3 -RRB- .
22829971	0	SB1518	111,117	JAK2	84,88	SB1518	JAK2	MESH:C561234	3717	Chemical	Gene	pacritinib|appos|START_ENTITY pacritinib|compound|END_ENTITY	The oral HDAC inhibitor pracinostat -LRB- SB939 -RRB- is efficacious and synergistic with the JAK2 inhibitor pacritinib -LRB- SB1518 -RRB- in preclinical models of AML .
25600203	0	SB1518	42,48	Janus_Kinase_2	68,82	SB1518	Janus Kinase 2	MESH:C561234	3717	Chemical	Gene	Metabolism|appos|START_ENTITY Metabolism|nmod|Inhibitor Inhibitor|compound|END_ENTITY	Metabolism and Disposition of Pacritinib -LRB- SB1518 -RRB- , an Orally Active Janus_Kinase_2 Inhibitor in Preclinical Species and Humans .
22527961	0	SB1518	84,90	Janus_kinase_2	124,138	SB1518	Janus kinase 2	MESH:C561234	3717	Chemical	Gene	discovery|nmod|START_ENTITY discovery|appos|inhibitors inhibitors|nmod|END_ENTITY	Structure-based design of oxygen-linked macrocyclic kinase inhibitors : discovery of SB1518 and SB1578 , potent inhibitors of Janus_kinase_2 -LRB- JAK2 -RRB- and Fms-like_tyrosine_kinase-3 -LRB- FLT3 -RRB- .
22965964	0	SB1518	56,62	Janus_kinase_2	30,44	SB1518	Janus kinase 2	MESH:C561234	3717	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Phase I study of a novel oral Janus_kinase_2 inhibitor , SB1518 , in patients with relapsed_lymphoma : evidence of clinical and biologic activity in multiple_lymphoma subtypes .
10602506	4	SB202190	456,464	p38	597,600	SB202190	p38	MESH:C090942	1432	Chemical	Gene	Treating|nmod|START_ENTITY inhibited|csubj|Treating inhibited|dep|treating treating|advcl|suppressing suppressing|dobj|activation activation|amod|END_ENTITY	Treating the cells with p38 inhibitor SB202190 inhibited p38 activation , but not ERK ; treating the cells with MEK-1 inhibitor PD98059 inhibited ERK activation without suppressing p38 activation .
11579095	5	SB202190	640,648	p38	715,718	SB202190	Brx	MESH:C090942	53344	Chemical	Gene	addition|nmod|START_ENTITY abrogates|nsubj|addition abrogates|advcl|showing showing|ccomp|required required|nsubjpass|activity activity|amod|END_ENTITY	However , addition of the p38 MAPK inhibitor SB202190 abrogates the enhancement of ERbeta activity by Brx , showing that p38 MAPK activity is required for the enhancement of ERbeta function by Brx .
21281706	6	SB202190	1098,1106	p38	1083,1086	SB202190	p38	MESH:C090942	81649(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	p , p ' - DDE-induced apoptosis was blocked by NAC -LRB- N-acetyl-L-cystein -RRB- preincubation and attenuated by pretreatment with p38 inhibitor -LRB- SB202190 -RRB- or actinomycin_D , but not with JNK inhibitor -LRB- SP600125 -RRB- .
24138903	9	SB202190	1267,1275	p38	1244,1247	SB202190	p38	MESH:C090942	1432	Chemical	Gene	blocking|nmod|START_ENTITY blocking|dobj|activation activation|amod|END_ENTITY	Moreover , blocking p38 MAPK activation by SB202190 significantly decreased gefitinib-induced MSH2 expression by increasing mRNA and protein instability .
24455679	0	SB202190	41,49	p38	22,25	SB202190	p38	MESH:C090942	81649(Tax:10116)	Chemical	Gene	MAPK|dobj|START_ENTITY MAPK|nsubj|effects effects|nmod|END_ENTITY	Protective effects of p38 MAPK inhibitor SB202190 against hippocampal apoptosis and spatial_learning_and_memory_deficits in a rat model of vascular_dementia .
16807361	0	SB202190	77,85	p38_mitogen-activated_protein_kinase	30,66	SB202190	p38 mitogen-activated protein kinase	MESH:C090942	81649(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|delivery delivery|nmod|inhibitor inhibitor|amod|END_ENTITY	Intracellular delivery of the p38_mitogen-activated_protein_kinase inhibitor SB202190 -LSB- 4 - -LRB- 4-fluorophenyl -RRB- -2 - -LRB- 4-hydroxyphenyl -RRB- -5 - -LRB- 4-pyridyl -RRB- 1H-imidazole -RSB- in renal tubular cells : a novel strategy to treat renal_fibrosis .
9738669	0	SB202190	0,8	p38_mitogen-activated_protein_kinase	35,71	SB202190	p38 mitogen-activated protein kinase	MESH:C090942	1432	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	SB202190 , a selective inhibitor of p38_mitogen-activated_protein_kinase , is a powerful regulator of LPS-induced mRNAs in monocytes .
15659807	0	SB203580	12,20	Cyp1a1	24,30	SB203580	Cyp1a1	MESH:C093642	1543	Chemical	Gene	START_ENTITY|nmod|induction induction|amod|END_ENTITY	Blockade by SB203580 of Cyp1a1 induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin , and the possible mechanism : possible involvement of the p38_mitogen-activated_protein_kinase pathway in shuttling of Ah_receptor overexpressed in COS-7 cells .
26772539	0	SB203580	0,8	G-CSF	19,24	SB203580	G-CSF	MESH:C093642	12985(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|production production|amod|END_ENTITY	SB203580 increases G-CSF production via a stem-loop destabilizing element in the 3 ' untranslated region in macrophages independently of its effect on p38_MAPK activity .
24563432	0	SB203580	10,18	TNF-a	79,84	SB203580	TNF-a	MESH:C093642	24835(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of SB203580 on pathologic change of pancreatic tissue and expression of TNF-a and IL-1b in rats with severe_acute_pancreatitis .
15661859	0	SB203580	128,136	glucose_transporter-4	37,58	SB203580	glucose transporter-4	MESH:C093642	25139(Tax:10116)	Chemical	Gene	kinase|dobj|START_ENTITY kinase|nsubj|inhibition inhibition|nmod|activity activity|amod|END_ENTITY	Endofacial competitive inhibition of glucose_transporter-4 intrinsic activity by the mitogen-activated protein kinase inhibitor SB203580 .
15665038	0	SB203580	51,59	glucose_transporter-4	92,113	SB203580	glucose transporter-4	MESH:C093642	6517	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|nmod|END_ENTITY	The p38 mitogen-activated protein kinase inhibitor SB203580 reduces glucose turnover by the glucose_transporter-4 of 3T3-L1 adipocytes in the insulin-stimulated state .
17316994	0	SB203580	0,8	interleukin-1_receptor_antagonist	18,51	SB203580	interleukin-1 receptor antagonist	MESH:C093642	3557	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	SB203580 enhances interleukin-1_receptor_antagonist gene expression in IFN-gamma-stimulated BV2 microglial cells through a composite nuclear factor-kappaB/PU .1 binding site .
26648769	0	SB203580	23,31	interleukin_6	69,82	SB203580	interleukin 6	MESH:C093642	16193(Tax:10090)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	The p38_MAPK inhibitor SB203580 differentially modulates LPS-induced interleukin_6 expression in macrophages .
10960075	0	SB203580	29,37	nuclear_factor-kappa_B	47,69	SB203580	nuclear factor-kappa B	MESH:C093642	4790	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|amod|END_ENTITY	The p38 MAP kinase inhibitor SB203580 enhances nuclear_factor-kappa_B transcriptional activity by a non-specific effect upon the ERK pathway .
11192368	0	SB203580	24,32	p38	4,7	SB203580	p38	MESH:C093642	81649(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	The p38 MAPK inhibitor , SB203580 , abrogates ischaemic preconditioning in rat heart but timing of administration is critical .
12508271	4	SB203580	509,517	p38	494,497	SB203580	ERK	MESH:C093642	5594	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	p38 inhibitor -LRB- SB203580 -RRB- prevented CsA-induced hemoglobin synthesis in K562 cells , although MEK/ERK inhibitor -LRB- U0126 -RRB- enhanced it by 3.3 times in K562 cells .
12781867	0	SB203580	56,64	p38	147,150	SB203580	p38	MESH:C093642	1432	Chemical	Gene	resistant|nmod|START_ENTITY resistant|xcomp|expressing expressing|dobj|mutant mutant|nmod|END_ENTITY	Phosphorylation of initiation factor 4E is resistant to SB203580 in cells expressing a drug-resistant mutant of stress-activated_protein_kinase_2a / p38 .
12975336	6	SB203580	1031,1039	p38	977,980	SB203580	mEH	MESH:C093642	13849(Tax:10090)	Chemical	Gene	abrogated|nsubj|START_ENTITY kinase|ccomp|abrogated kinase|nsubj|protein protein|amod|END_ENTITY	The p38 mitogen-activated protein -LRB- MAP -RRB- kinase inhibitors SB203580 and SB202190 also abrogated the insulin-mediated increase in mEH protein .
16903868	6	SB203580	1043,1051	p38	1023,1026	SB203580	MEK	MESH:C093642	5609	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Enhanced neutrophil motility and morphological change were inhibited by MEK -LSB- mitogen-activated protein kinase -LRB- MAPK -RRB- / extracellular_signal-regulated_kinase -LRB- ERK -RRB- kinase -RSB- inhibitors -LRB- PD98059 and U0126 -RRB- , and a phosphatidylinositol_3-kinase -LRB- PI3K -RRB- inhibitor -LRB- wortmannin -RRB- , but not by a p38 MAPK inhibitor -LRB- SB203580 -RRB- .
17558278	0	SB203580	49,57	p38	0,3	SB203580	p38	MESH:C093642	1432	Chemical	Gene	block|compound|START_ENTITY kinase|dobj|block kinase|nsubj|protein protein|amod|END_ENTITY	p38 mitogen-activated protein kinase independent SB203580 block of H2O2-induced increase in GABAergic mIPSC amplitude .
18655782	0	SB203580	0,8	p38	41,44	SB203580	p38	MESH:C093642	1432	Chemical	Gene	activates|advmod|START_ENTITY activates|nsubj|inhibitor inhibitor|nmod|pathway pathway|amod|END_ENTITY	SB203580 , a pharmacological inhibitor of p38 MAP kinase transduction pathway activates ERK and JNK MAP kinases in primary cultures of human hepatocytes .
21362316	0	SB203580	134,142	p38	153,156	SB203580	p38	MESH:C093642	81649(Tax:10116)	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nmod|pathway pathway|amod|END_ENTITY	Coronary microembolization induced myocardial contractile_dysfunction and tumor_necrosis_factor-a mRNA expression partly inhibited by SB203580 through a p38 mitogen-activated protein kinase pathway .
21549858	0	SB203580	62,70	p38	14,17	SB203580	p38	MESH:C093642	26416(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	The selective p38 mitogen-activated protein kinase inhibitor , SB203580 , improves renal_disease in MRL/lpr mouse model of systemic_lupus .
22605923	6	SB203580	1400,1408	p38	1438,1441	SB203580	p38	MESH:C093642	5594	Chemical	Gene	administration|nmod|START_ENTITY disappeared|nmod|administration disappeared|nsubj|inhibitor inhibitor|nmod|pathway pathway|amod|END_ENTITY	Pretreatment with 10 -LRB- -10 -RRB- M 17-b-estradiol greatly inhibited the increased expression and production of IL-6 , IL-1 , and TNF-a induced by hyperosmolarity , whereas with the administration of SB203580 -LRB- 10 M -RRB- , an inhibitor of the p38 pathway , the inhibiting effect of 17-b-estradiol disappeared .
25528965	0	SB203580	61,69	p38	138,141	SB203580	p38	MESH:C093642	1432	Chemical	Gene	analogues|nummod|START_ENTITY cells|nmod|analogues differentiation|nmod|cells correlates|nsubj|differentiation correlates|nmod|Wnt Wnt|nmod|signaling signaling|amod|END_ENTITY	Cardiomyocyte differentiation of pluripotent stem cells with SB203580 analogues correlates with Wnt pathway CK1 inhibition independent of p38 MAPK signaling .
10037150	0	SB203580	74,82	p38_mitogen-activated_protein_kinase	26,62	SB203580	p38 mitogen-activated protein kinase	MESH:C093642	1432	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Raf-1 is activated by the p38_mitogen-activated_protein_kinase inhibitor , SB203580 .
10702313	0	SB203580	34,42	p38_mitogen-activated_protein_kinase	229,265	SB203580	p38 mitogen-activated protein kinase	MESH:C093642	1432	Chemical	Gene	blocks|nsubj|START_ENTITY blocks|advmod|independently independently|advcl|END_ENTITY	The pyridinyl_imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity , protein_kinase_B phosphorylation , and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38_mitogen-activated_protein_kinase .
10876075	0	SB203580	0,8	p38_mitogen-activated_protein_kinase	14,50	SB203580	p38 mitogen-activated protein kinase	MESH:C093642	81649(Tax:10116)	Chemical	Gene	blocks|advmod|START_ENTITY blocks|nsubj|inhibitor inhibitor|amod|END_ENTITY	SB203580 , the p38_mitogen-activated_protein_kinase inhibitor blocks the inhibitory effect of beta-amyloid on long-term potentiation in the rat hippocampus .
12134900	0	SB203580	123,131	p38_mitogen-activated_protein_kinase	157,193	SB203580	p38 mitogen-activated protein kinase	MESH:C093642	1432	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Modulation of phorbol_ester-induced regulation of matrix metalloproteinases and tissue inhibitors of metalloproteinases by SB203580 , a specific inhibitor of p38_mitogen-activated_protein_kinase .
14512145	0	SB203580	35,43	p38_mitogen-activated_protein_kinase	70,106	SB203580	p38 mitogen-activated protein kinase	MESH:C093642	81649(Tax:10116)	Chemical	Gene	infusion|nmod|START_ENTITY infusion|appos|inhibitor inhibitor|nmod|END_ENTITY	Continuous intrathecal infusion of SB203580 , a selective inhibitor of p38_mitogen-activated_protein_kinase , reduces the damage of hind-limb function after thoracic spinal_cord_injury in rat .
15659807	0	SB203580	12,20	p38_mitogen-activated_protein_kinase	137,173	SB203580	p38 mitogen-activated protein kinase	MESH:C093642	1432	Chemical	Gene	Blockade|nmod|START_ENTITY Blockade|dep|involvement involvement|nmod|pathway pathway|amod|END_ENTITY	Blockade by SB203580 of Cyp1a1 induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin , and the possible mechanism : possible involvement of the p38_mitogen-activated_protein_kinase pathway in shuttling of Ah_receptor overexpressed in COS-7 cells .
18562123	0	SB203580	0,8	p38_mitogen-activated_protein_kinase	12,48	SB203580	p38 mitogen-activated protein kinase	MESH:C093642	81649(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	SB203580 , a p38_mitogen-activated_protein_kinase inhibitor , fails to improve functional outcome following a moderate spinal_cord_injury in rat .
20956267	0	SB203580	0,8	p38_mitogen-activated_protein_kinase	12,48	SB203580	p38 mitogen-activated protein kinase	MESH:C093642	26416(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	SB203580 , a p38_mitogen-activated_protein_kinase inhibitor , suppresses the development of endometriosis by down-regulating proinflammatory cytokines and proteolytic factors in a mouse model .
23158801	0	SB203580	61,69	p38_mitogen-activated_protein_kinase	14,50	SB203580	p38 mitogen-activated protein kinase	MESH:C093642	81649(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Mechanism Mechanism|nmod|inhibitor inhibitor|amod|END_ENTITY	-LSB- Mechanism of p38_mitogen-activated_protein_kinase inhibitor SB203580 to glucocorticoid sensitivity -RSB- .
11679403	0	SB203580	24,32	p38alpha	72,80	SB203580	p38alpha	MESH:C093642	81649(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY mediated|nsubjpass|effects mediated|nmod|inhibition inhibition|nmod|kinase kinase|amod|END_ENTITY	Antiischemic effects of SB203580 are mediated through the inhibition of p38alpha mitogen-activated protein kinase : Evidence from ectopic expression of an inhibition-resistant kinase .
16532349	0	SB203580	45,53	p38alpha	55,63	SB203580	p38alpha	MESH:C093642	1432	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Enhancement of anti-inflammatory tendency by SB203580 , p38alpha specific inhibitor , in human fibroblast-like synoviocyte cell line , MH7A .
23825920	1	SB216763	160,168	glycogen_synthase_kinase-3b	121,148	SB216763	glycogen synthase kinase-3b	MESH:C417521	2932	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Part A : Monitoring mitochondrial depolarization with JC-1 and artifactual fluorescence by the glycogen_synthase_kinase-3b inhibitor , SB216763 .
19264522	0	SB225002	71,79	CXCR2	45,50	SB225002	CXCR2	MESH:C112019	12765(Tax:10090)	Chemical	Gene	antagonist|dobj|START_ENTITY antagonist|nsubj|effects effects|nmod|receptor receptor|compound|END_ENTITY	The effects of the selective and non-peptide CXCR2 receptor antagonist SB225002 on acute and long-lasting models of nociception in mice .
19422399	0	SB265610	0,8	CXCR2	56,61	SB265610	CXCR2	MESH:C549500	3579	Chemical	Gene	agonist|nsubj|START_ENTITY agonist|nmod|receptor receptor|compound|END_ENTITY	SB265610 is an allosteric , inverse agonist at the human CXCR2 receptor .
15950380	0	SB366791	47,55	TRPV1	21,26	SB366791	TRPV1	MESH:C477659	83810(Tax:10116)	Chemical	Gene	antagonist|dobj|START_ENTITY antagonist|nsubj|Effects Effects|nmod|receptor receptor|compound|END_ENTITY	Effects of the novel TRPV1 receptor antagonist SB366791 in vitro and in vivo in the rat .
19038965	0	SB366791	0,8	TRPV1	12,17	SB366791	TRPV1	MESH:C477659	193034(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	SB366791 , a TRPV1 antagonist , potentiates analgesic effects of systemic morphine in a murine model of bone_cancer_pain .
26807171	6	SB431542	905,913	TGF-b	872,877	SB431542	TRAF6	MESH:C459179	311245(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	A TGF-b type I receptor inhibitor -LRB- SB431542 -RRB- was used to inhibit SMAD2/3 phosphorylation .
7791085	0	SB_202235	36,45	5-lipoxygenase	70,84	SB 202235	5-lipoxygenase	MESH:C094196	240	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Pharmacological characterization of SB_202235 , a potent and selective 5-lipoxygenase inhibitor : effects in models of allergic_asthma .
7562492	0	SB_203220	0,9	angiotensin_II	19,33	SB 203220	angiotensin II	MESH:C095799	24179(Tax:10116)	Chemical	Gene	START_ENTITY|dep|antagonist antagonist|compound|END_ENTITY	SB_203220 : a novel angiotensin_II receptor antagonist and renoprotective agent .
7562496	0	SB_203347	0,9	phospholipase_A2	34,50	SB 203347	phospholipase A2	MESH:C095801	151056	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	SB_203347 , an inhibitor of 14 kDa phospholipase_A2 , alters human neutrophil arachidonic_acid release and metabolism and prolongs survival in murine endotoxin_shock .
10321729	0	SB_203580	10,19	c-Raf	39,44	SB 203580	c-Raf	MESH:C093642	5894	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|nmod|END_ENTITY	Effect of SB_203580 on the activity of c-Raf in vitro and in vivo .
10051531	3	SB_203580	543,552	p38	528,531	SB 203580	p38	MESH:C093642	1432	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	LPS-mediated NO release and the inducible form of NO synthase expression were inhibited by the p38 inhibitor , SB_203580 , but not by the MAPK kinase inhibitor , PD_98059 .
10371163	0	SB_203580	112,121	p38	69,72	SB 203580	p38	MESH:C093642	1432	Chemical	Gene	specificity|nmod|START_ENTITY validate|dobj|specificity Use|xcomp|validate Use|nmod|mutant mutant|nmod|END_ENTITY	Use of a drug-resistant mutant of stress-activated_protein_kinase_2a / p38 to validate the in vivo specificity of SB_203580 .
11153597	0	SB_203580	36,45	p38	14,17	SB 203580	p38	MESH:C093642	81649(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Effect of the p38 kinase inhibitor , SB_203580 , on sephadex induced airway inflammation in the rat .
11303787	0	SB_203580	38,47	p38	49,52	SB 203580	p38	MESH:C093642	81649(Tax:10116)	Chemical	Gene	Inhibition|nmod|START_ENTITY kinase|advcl|Inhibition kinase|nsubj|protein protein|amod|END_ENTITY	Inhibition of caspase-3 activation by SB_203580 , p38 mitogen-activated protein kinase inhibitor in nitric_oxide-induced apoptosis of PC-12 cells .
19336000	0	SB_203580	81,90	p38	66,69	SB 203580	p38	MESH:C093642	1432	Chemical	Gene	inhibitors|dobj|START_ENTITY inhibitors|nsubj|Non-specific Non-specific|nmod|inhibition inhibition|nmod|CK1 CK1|nmod|END_ENTITY	Non-specific in vivo inhibition of CK1 by the pyridinyl_imidazole p38 inhibitors SB_203580 and SB_202190 .
9624152	0	SB_203580	85,94	p38	70,73	SB 203580	p38	MESH:C093642	1432	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Acquisition of sensitivity of stress-activated protein kinases to the p38 inhibitor , SB_203580 , by alteration of one or more amino_acids within the ATP binding pocket .
9647257	0	SB_203580	0,9	p38	19,22	SB 203580	p38	MESH:C093642	534492(Tax:9913)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|kinase kinase|amod|END_ENTITY	SB_203580 inhibits p38 mitogen-activated protein kinase , nitric_oxide production , and inducible nitric_oxide synthase in bovine cartilage-derived chondrocytes .
10411570	0	SB_203580	0,9	p38_mitogen-activated_protein_kinase	27,63	SB 203580	p38 mitogen-activated protein kinase	MESH:C093642	1432	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	SB_203580 , an inhibitor of p38_mitogen-activated_protein_kinase , enhances constitutive apoptosis of cytokine-deprived human eosinophils .
9808700	0	SB_207499	0,9	tumor_necrosis_factor_alpha	79,106	SB 207499	tumor necrosis factor alpha	MESH:C433247	7124	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|production production|compound|END_ENTITY	SB_207499 -LRB- Ariflo -RRB- , a second generation phosphodiesterase 4 inhibitor , reduces tumor_necrosis_factor_alpha and interleukin-4 production in vivo .
9595411	0	SB_209670	0,9	endothelin-1	49,61	SB 209670	endothelin-1	MESH:C087551	403424(Tax:9615)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|actions actions|nmod|END_ENTITY	SB_209670 inhibits the arrhythmogenic actions of endothelin-1 in the anesthetized dog .
11752131	2	SB_235375	49,58	neurokinin-3_receptor	121,142	SB 235375	neurokinin-3 receptor	MESH:C444647	100135627(Tax:10141)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	SB_235375 , a low central nervous system-penetrant , potent and selective neurokinin-3_receptor antagonist , inhibits citric_acid-induced cough and airways hyper-reactivity in guinea_pigs .
10734180	0	SB_239063	0,9	p38	20,23	SB 239063	p38	MESH:C406525	26416(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	SB_239063 , a potent p38 MAP kinase inhibitor , reduces inflammatory cytokine production , airways eosinophil infiltration , and persistence .
11172750	0	SB_239063	0,9	p38	19,22	SB 239063	p38	MESH:C406525	1432	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	SB_239063 , a novel p38 inhibitor , attenuates early neuronal_injury following ischemia .
11160612	0	SB_239063	0,9	p38_mitogen-activated_protein_kinase	31,67	SB 239063	p38 mitogen-activated protein kinase	MESH:C406525	81649(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	SB_239063 , a second-generation p38_mitogen-activated_protein_kinase inhibitor , reduces brain_injury and neurological_deficits in cerebral focal ischemia .
11069728	0	SB_242235	24,33	p38	47,50	SB 242235	p38	MESH:C403289	534492(Tax:9913)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Differential effects of SB_242235 , a selective p38 mitogen-activated protein kinase inhibitor , on IL-1 treated bovine and human cartilage/chondrocyte cultures .
10643714	0	SB_242235	30,39	p38_mitogen-activated_protein_kinase	66,102	SB 242235	p38 mitogen-activated protein kinase	MESH:C403289	81649(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|appos|inhibitor inhibitor|nmod|END_ENTITY	Disease-modifying activity of SB_242235 , a selective inhibitor of p38_mitogen-activated_protein_kinase , in rat adjuvant-induced_arthritis .
15619665	0	SC-19220	0,8	EP1	50,53	SC-19220	EP1	MESH:D012531	19216(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|nmod|END_ENTITY	SC-19220 , antagonist of prostaglandin_E2 receptor EP1 , inhibits osteoclastogenesis by RANKL .
15619665	0	SC-19220	0,8	RANKL	86,91	SC-19220	RANKL	MESH:D012531	21943(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	SC-19220 , antagonist of prostaglandin_E2 receptor EP1 , inhibits osteoclastogenesis by RANKL .
14522004	0	SC-236	88,94	cyclooxygenase-2	60,76	SC-236	cyclooxygenase-2	MESH:C119130	29527(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Differential antinociceptive effects induced by a selective cyclooxygenase-2 inhibitor -LRB- SC-236 -RRB- on dorsal horn neurons and spinal withdrawal reflexes in anesthetized spinal rats .
15709198	0	SC-236	168,174	cyclooxygenase-2	178,194	SC-236	cyclooxygenase-2	MESH:C119130	19225(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Antitumor activity of ZD6474 , a vascular_endothelial_growth_factor-2 and epidermal_growth_factor_receptor small molecule tyrosine kinase inhibitor , in combination with SC-236 , a cyclooxygenase-2 inhibitor .
2552769	0	SC-41930	50,58	leukotriene-B4_receptor	14,37	SC-41930	leukotriene-B4 receptor	MESH:C059950	1241	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	The effect of leukotriene-B4_receptor antagonist , SC-41930 , on acetic_acid-induced colonic_inflammation .
1650525	0	SC-41930	0,8	leukotriene_B4_receptor	12,35	SC-41930	leukotriene B4 receptor	MESH:C059950	1241	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	SC-41930 , a leukotriene_B4_receptor antagonist , inhibits 12 -LRB- S -RRB- - hydroxyeicosatetraenoic_acid -LRB- 12 -LRB- S -RRB- - HETE -RRB- binding to epidermal cells .
7699700	0	SC-41930	65,73	leukotriene_B4_receptor	18,41	SC-41930	leukotriene B4 receptor	MESH:C059950	1241	Chemical	Gene	related|nmod|START_ENTITY antagonists|acl|related antagonists|amod|END_ENTITY	Second-generation leukotriene_B4_receptor antagonists related to SC-41930 : heterocyclic replacement of the methyl_ketone pharmacophore .
8638901	0	SC-41930	10,18	leukotriene_B4_receptor	39,62	SC-41930	leukotriene B4 receptor	MESH:C059950	100379538(Tax:10141)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|antagonist antagonist|amod|END_ENTITY	Effect of SC-41930 , a potent selective leukotriene_B4_receptor antagonist , in the guinea_pig model of middle_ear_inflammation .
8138959	0	SC-45694	61,69	leukotriene_B4_receptor	4,27	SC-45694	leukotriene B4 receptor	MESH:C086425	1241	Chemical	Gene	activities|nmod|START_ENTITY activities|amod|END_ENTITY	The leukotriene_B4_receptor agonist/antagonist activities of SC-45694 in human neutrophils .
24091016	0	SC-514	0,6	IKKb	33,37	SC-514	IKKb	MESH:C477523	16150(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	SC-514 , a selective inhibitor of IKKb attenuates RANKL-induced osteoclastogenesis and NF-kB activation .
7505365	0	SC-52458	16,24	AT1	67,70	SC-52458	AT1	MESH:C084927	24180(Tax:10116)	Chemical	Gene	START_ENTITY|appos|receptor receptor|compound|END_ENTITY	Pharmacology of SC-52458 , an orally active , nonpeptide angiotensin AT1 receptor antagonist .
9194514	0	SC-52458	11,19	AT1	36,39	SC-52458	AT1	MESH:C084927	24180(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Effects of SC-52458 , an angiotensin AT1 receptor antagonist , in the dog .
7601505	0	SC-53228	82,90	leukotriene_B4_receptor	46,69	SC-53228	leukotriene B4 receptor	MESH:C082206	1241	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Antiinflammatory effects of second-generation leukotriene_B4_receptor antagonist , SC-53228 : impact upon leukotriene B4 - and 12 -LRB- R -RRB- - HETE-mediated events .
7628862	0	SC-53228	125,133	leukotriene_B4_receptor	89,112	SC-53228	leukotriene B4 receptor	MESH:C082206	100379538(Tax:10141)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Dermal_inflammation in primates , mice , and guinea_pigs : attenuation by second-generation leukotriene_B4_receptor antagonist , SC-53228 .
7607739	0	SC-56525	11,19	renin	45,50	SC-56525	renin	MESH:C094558	5972	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Effects of SC-56525 , a potent , orally active renin inhibitor , in salt-depleted and renal hypertensive dogs .
16385588	6	SC-58125	987,995	COX-2	969,974	SC-58125	COX-1	MESH:C090859	4512	Chemical	Gene	inhibitors|dep|START_ENTITY inhibitors|compound|END_ENTITY	Intact cells of ARH-77 converted 14C-labeled arachidonic_acid to prostaglandin_E2 , F2alpha , and D2 , and this activity was dose-dependently inhibited by selective COX-2 inhibitors -LRB- SC-58125 and NS-398 -RRB- , a non-selective COX inhibitor -LRB- indomethacin -RRB- , and relatively high concentrations of a selective COX-1 inhibitor -LRB- SC-560 -RRB- .
11687954	0	SC-58125	30,38	cyclooxygenase-2	2,18	SC-58125	cyclooxygenase-2	MESH:C090859	5743	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	A cyclooxygenase-2 inhibitor -LRB- SC-58125 -RRB- blocks growth of established human colon_cancer xenografts .
21441310	0	SC-58236	60,68	COX-2	49,54	SC-58236	COX-2	MESH:C119130	29527(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|inhibition inhibition|nmod|END_ENTITY	Renal protective effect of chronic inhibition of COX-2 with SC-58236 in streptozotocin-diabetic rats .
9751091	0	SC-58635	48,56	cyclooxygenase_2	66,82	SC-58635	cyclooxygenase 2	MESH:C105934	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Preliminary study of the safety and efficacy of SC-58635 , a novel cyclooxygenase_2 inhibitor : efficacy and safety in two placebo-controlled trials in osteoarthritis and rheumatoid_arthritis , and studies of gastrointestinal and platelet effects .
14739610	2	SC236	260,265	Cox-2	243,248	SC236	Cox-2	MESH:C119130	4513	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	We studied the role of Cox-2 inhibition in apoptosis induced by a selective Cox-2 inhibitor , SC236 -LRB- a structural analogue of celecoxib -RRB- in two colon_cancer cell lines , HT29 -LRB- expressing Cox-2 protein -RRB- and HCT116 -LRB- not expressing Cox-2 protein -RRB- .
7747166	0	SC41661A	96,104	5-lipoxygenase	140,154	SC41661A	5-lipoxygenase	MESH:C081292	240	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Morphologic changes of apoptosis induced in human chronic_myelogenous_leukemia `` blast '' cells by SC41661A -LRB- Searle -RRB- , a selective inhibitor of 5-lipoxygenase .
8497493	0	SC41661A	88,96	5-lipoxygenase	123,137	SC41661A	5-lipoxygenase	MESH:C081292	240	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Induction of apoptosis in blood cells from a patient with acute_myelogenous_leukemia by SC41661A , a selective inhibitor of 5-lipoxygenase .
19186029	0	SC58236	11,18	COX-2	32,37	SC58236	COX-2	MESH:C119130	26198(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Effects of SC58236 , a selective COX-2 inhibitor , on epileptogenesis and spontaneous seizures in a rat model for temporal_lobe_epilepsy .
24407843	0	SC82510	24,31	DRAK	8,12	SC82510	DRAK	null	32097(Tax:7227)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	A novel DRAK inhibitor , SC82510 , promotes axon branching of adult sensory neurons in vitro .
15119195	0	SCH-23390	38,47	D1-receptor	15,26	SCH-23390	D1-receptor	MESH:C534628	13488(Tax:10090)	Chemical	Gene	antagonist|dobj|START_ENTITY antagonist|nsubj|Effect Effect|nmod|END_ENTITY	-LSB- Effect of the D1-receptor antagonist SCH-23390 on the individual and aggressive_behavior in male mice with various aggression experience -RSB- .
1491805	0	SCH-23390	36,45	zif268	100,106	SCH-23390	zif268	MESH:C534628	24330(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|levels levels|nmod|END_ENTITY	The dopamine D1 receptor antagonist SCH-23390 decreases the mRNA levels of the transcription factor zif268 -LRB- krox-24 -RRB- in adult rat intact striatum -- an in situ hybridization study .
12692222	0	SCH-351125	71,81	CCR5	54,58	SCH-351125	CCR5	MESH:C438583	1234	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|nummod|END_ENTITY	Analysis of the mechanism by which the small-molecule CCR5 antagonists SCH-351125 and SCH-350581 inhibit human_immunodeficiency_virus_type_1 entry .
15935415	0	SCH-417690	123,133	CCR5	107,111	SCH-417690	CCR5	MESH:C486781	1234	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Generation and properties of a human_immunodeficiency_virus_type_1 isolate resistant to the small molecule CCR5 inhibitor , SCH-417690 -LRB- SCH-D -RRB- .
22391039	0	SCH-527123	22,32	CXCR2	4,9	SCH-527123	CXCR2	MESH:C516686	3579	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	The CXCR2 antagonist , SCH-527123 , shows antitumor activity and sensitizes cells to oxaliplatin in preclinical colon_cancer models .
11465634	0	SCH23390	49,57	dopamine_D1_receptor	16,36	SCH23390	dopamine D1 receptor	MESH:C534628	1812	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	The `` selective '' dopamine_D1_receptor antagonist , SCH23390 , is a potent and high efficacy agonist at cloned human serotonin2C receptors .
15721793	0	SCH23390	51,59	dopamine_D1_receptor	19,39	SCH23390	dopamine D1 receptor	MESH:C534628	1812	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|antagonist antagonist|amod|END_ENTITY	The effects of the dopamine_D1_receptor antagonist SCH23390 on memory reconsolidation following reminder-activated retrieval in day-old chicks .
21946101	0	SCH23390	0,8	dopamine_D1_receptor	12,32	SCH23390	dopamine D1 receptor	MESH:C534628	13488(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	SCH23390 , a dopamine_D1_receptor antagonist , suppressed scratching behavior induced by compound 48/80 in mice .
7752807	0	SCH23390	127,135	dopamine_D1_receptor	94,114	SCH23390	dopamine D1 receptor	MESH:C534628	1812	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	The antisecretory effects of clozapine , a dopamine_D4_receptor antagonist , are blocked by the dopamine_D1_receptor antagonist , SCH23390 .
11598491	0	SCH23390	62,70	dopamine_d1_receptor	24,44	SCH23390	dopamine d1 receptor	MESH:C534628	1812	Chemical	Gene	-RSB-|compound|START_ENTITY binding|nmod|-RSB- END_ENTITY|amod|binding	Measurement of cortical dopamine_d1_receptor binding with 11C -LSB- SCH23390 -RSB- : a test-retest analysis .
1706428	0	SCH32615	73,81	enkephalinase	109,122	SCH32615	enkephalinase	MESH:C062344	4311	Chemical	Gene	L-phenylalanyl-beta-alanine|appos|START_ENTITY L-phenylalanyl-beta-alanine|appos|inhibitor inhibitor|appos|END_ENTITY	Effects of -LSB- N - -LRB- L - -LRB- 1-carboxy-2-phenyl -RRB- ethyl -RSB- - L-phenylalanyl-beta-alanine -LRB- SCH32615 -RRB- , a neutral endopeptidase -LRB- enkephalinase -RRB- inhibitor , on levels of enkephalin , encrypted enkephalins and substance_P in cerebrospinal fluid and plasma of primates .
2357551	0	SCH32615	58,66	enkephalinase	71,84	SCH32615	enkephalinase	MESH:C062344	24590(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	The antinociceptive effects of intrathecally administered SCH32615 , an enkephalinase inhibitor in the rat .
19643947	0	SCH527123	0,9	CXCR2	19,24	SCH527123	CXCR2	MESH:C516686	3579	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	SCH527123 , a novel CXCR2 antagonist , inhibits ozone-induced neutrophilia in healthy subjects .
20124408	0	SCH529074	0,9	p53	48,51	SCH529074	p53	MESH:C549329	7157	Chemical	Gene	START_ENTITY|appos|activator activator|nmod|END_ENTITY	SCH529074 , a small molecule activator of mutant p53 , which binds p53 DNA binding domain -LRB- DBD -RRB- , restores growth-suppressive function to mutant p53 and interrupts HDM2-mediated ubiquitination of wild type p53 .
12700117	0	SCH58500	41,49	p53	23,26	SCH58500	p53	null	7157	Chemical	Gene	delivery|nmod|START_ENTITY delivery|compound|END_ENTITY	Efficacy of adenoviral p53 delivery with SCH58500 in the intracranial 9l and RG2 models .
15494604	0	SCH66336	90,98	Akt	102,105	SCH66336	Akt	MESH:C115354	207	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effects of insulin-like_growth_factor_binding_protein-3 and farnesyltransferase inhibitor SCH66336 on Akt expression and apoptosis in non-small-cell_lung_cancer cells .
11606389	0	SCH66336	43,51	P-glycoprotein	90,104	SCH66336	P-glycoprotein	MESH:C115354	5243	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	The farnesyl protein transferase inhibitor SCH66336 is a potent inhibitor of MDR1 product P-glycoprotein .
15994961	0	SCH66336	30,38	eukaryotic_translation_elongation_factor_2	72,114	SCH66336	eukaryotic translation elongation factor 2	MESH:C115354	1938	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Farnesyltransferase inhibitor SCH66336 induces rapid phosphorylation of eukaryotic_translation_elongation_factor_2 in head_and_neck_squamous_cell_carcinoma cells .
15494604	0	SCH66336	90,98	insulin-like_growth_factor_binding_protein-3	11,55	SCH66336	insulin-like growth factor binding protein-3	MESH:C115354	3486	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Effects of insulin-like_growth_factor_binding_protein-3 and farnesyltransferase inhibitor SCH66336 on Akt expression and apoptosis in non-small-cell_lung_cancer cells .
25041572	0	SCH_221510	88,98	nociceptin	29,39	SCH 221510	nociceptin	MESH:C530605	5368	Chemical	Gene	system|nmod|START_ENTITY system|compound|END_ENTITY	Activation of the endogenous nociceptin system by selective nociceptin_receptor agonist SCH_221510 produces antitransit and antinociceptive effect : a novel strategy for treatment of diarrhea-predominant IBS .
8497339	0	SCH_23390	62,71	dopamine_D1_receptor	27,47	SCH 23390	dopamine D1 receptor	MESH:C534628	1812	Chemical	Gene	antagonism|nmod|START_ENTITY antagonism|amod|END_ENTITY	Cocaine-induced behaviour : dopamine_D1_receptor antagonism by SCH_23390 prevents expression of conditioned sensitisation following repeated administration of cocaine .
6193364	0	SCH_31846	53,62	Angiotensin-converting_enzyme	0,29	SCH 31846	Angiotensin-converting enzyme	MESH:C038812	24310(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Angiotensin-converting_enzyme inhibitory activity of SCH_31846 , a new non-sulfhydryl inhibitor .
6193365	0	SCH_31846	29,38	angiotensin-converting_enzyme	57,86	SCH 31846	angiotensin-converting enzyme	MESH:C038812	610668(Tax:9615)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Antihypertensive activity of SCH_31846 , a non-sulfhydryl angiotensin-converting_enzyme inhibitor .
1874283	0	SCH_32615	59,68	enkephalinase	33,46	SCH 32615	enkephalinase	MESH:C062344	24590(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|appos|END_ENTITY	The neutral_endopeptidase-24 .11 -LRB- enkephalinase -RRB- inhibitor , SCH_32615 , increases dopamine metabolism in the nucleus accumbens of the rat .
2017447	0	SCH_32615	114,123	enkephalinase	90,103	SCH 32615	enkephalinase	MESH:C062344	24590(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|inhibitor inhibitor|compound|END_ENTITY	Analgesic and acute central nervous system side effects of the intravenously administered enkephalinase inhibitor SCH_32615 .
7566505	0	SCH_32615	11,20	enkephalinase	25,38	SCH 32615	enkephalinase	MESH:C062344	4311	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effects of SCH_32615 , an enkephalinase inhibitor , on D-1_and_D-2 dopamine receptor-mediated behaviors .
7726437	0	SCH_32615	0,9	enkephalinase	14,27	SCH 32615	enkephalinase	MESH:C062344	17380(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	SCH_32615 , an enkephalinase inhibitor , enhances pregnancy-induced analgesia in mice .
7741304	0	SCH_32615	28,37	enkephalinase	3,16	SCH 32615	enkephalinase	MESH:C062344	17380(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	An enkephalinase inhibitor , SCH_32615 , augments analgesia induced by surgery in mice .
8418713	0	SCH_32615	48,57	enkephalinase	23,36	SCH 32615	enkephalinase	MESH:C062344	4311	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Acute toxicology of an enkephalinase inhibitor -LRB- SCH_32615 -RRB- given intrathecally in the ewe .
3036028	0	SCH_33844	53,62	Angiotensin_converting_enzyme	0,29	SCH 33844	Angiotensin converting enzyme	MESH:C052555	24310(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Angiotensin_converting_enzyme inhibitory activity of SCH_33844 -LRB- spirapril -RRB- in rats , dogs and monkeys .
2884941	0	SCH_33844	102,111	angiotensin_converting_enzyme	61,90	SCH 33844	angiotensin converting enzyme	MESH:C052555	24310(Tax:10116)	Chemical	Gene	Antihypertensive|appos|START_ENTITY Antihypertensive|appos|profile profile|nmod|inhibitor inhibitor|compound|END_ENTITY	Antihypertensive , hemodynamic and autonomic profile of a new angiotensin_converting_enzyme inhibitor , SCH_33844 -LRB- spirapril -RRB- .
2325830	0	SCH_34826	39,48	enkephalinase	15,28	SCH 34826	enkephalinase	MESH:C056319	24590(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Effects of the enkephalinase inhibitor SCH_34826 on the sleep-waking cycle and EEG activity in the rat .
3164388	0	SCH_34826	16,25	enkephalinase	44,57	SCH 34826	enkephalinase	MESH:C056319	24590(Tax:10116)	Chemical	Gene	analgesic|nmod|START_ENTITY analgesic|nsubj|inhibitor inhibitor|amod|END_ENTITY	Pharmacology of SCH_34826 , an orally active enkephalinase inhibitor analgesic .
8309954	0	SCH_34826	79,88	enkephalinase	54,67	SCH 34826	enkephalinase	MESH:C056319	17380(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Sex differences in the antinociceptive effects of the enkephalinase inhibitor , SCH_34826 .
11585437	0	SCH_351125	137,147	CCR5	179,183	SCH 351125	CCR5	MESH:C438583	1234	Chemical	Gene	bipiperidine_N-oxide|appos|START_ENTITY carbonyl|dep|bipiperidine_N-oxide Discovery|dep|carbonyl Discovery|dep|antagonist antagonist|compound|END_ENTITY	Discovery of 4 - -LSB- -LRB- Z -RRB- - -LRB- 4-bromophenyl -RRB- - _ -LRB- ethoxyimino -RRB- methyl -RSB- -1 ' - -LSB- -LRB- 2,4-dimethyl-3 - _ pyridinyl -RRB- carbonyl -RSB- -4 ' - methyl-1 ,4 ' - _ bipiperidine_N-oxide -LRB- SCH_351125 -RRB- : an orally bioavailable human CCR5 antagonist for the treatment of HIV_infection .
11606733	0	SCH_351125	7,17	CCR5	96,100	SCH 351125	CCR5	MESH:C438583	1234	Chemical	Gene	SCH-C|appos|START_ENTITY SCH-C|appos|antagonist antagonist|nmod|END_ENTITY	SCH-C -LRB- SCH_351125 -RRB- , an orally bioavailable , small molecule antagonist of the chemokine receptor CCR5 , is a potent inhibitor_of_HIV-1_infection in vitro and in vivo .
11959565	0	SCH_351125	57,67	CCR5	72,76	SCH 351125	CCR5	MESH:C438583	1234	Chemical	Gene	interactions|appos|START_ENTITY interactions|appos|antagonist antagonist|compound|END_ENTITY	Anti-human immunodeficiency virus interactions of SCH-C -LRB- SCH_351125 -RRB- , a CCR5 antagonist , with other antiretroviral agents in vitro .
12639563	0	SCH_351125	65,75	CCR5	100,104	SCH 351125	CCR5	MESH:C438583	1234	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Biological evaluation and interconversion studies of rotamers of SCH_351125 , an orally bioavailable CCR5 antagonist .
16012074	0	SCH_351125	84,94	CCR5	98,102	SCH 351125	CCR5	MESH:C438583	1234	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Identification of human liver cytochrome_P450 enzymes involved in the metabolism of SCH_351125 , a CCR5 antagonist .
7835222	0	SCH_39166	69,78	dopamine_D-1_receptor	34,55	SCH 39166	dopamine D-1 receptor	MESH:C058081	1812	Chemical	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Studies on the glucuronidation of dopamine_D-1_receptor antagonists , SCH_39166 and SCH_23390 , by human liver microsomes .
2547941	0	SCH_39370	0,9	atrial_natriuretic_factor	89,114	SCH 39370	atrial natriuretic factor	MESH:C060631	24602(Tax:10116)	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|nmod|END_ENTITY	SCH_39370 , a neutral_metalloendopeptidase inhibitor , potentiates biological responses to atrial_natriuretic_factor and lowers blood pressure in desoxycorticosterone_acetate-sodium hypertensive rats .
2547941	0	SCH_39370	0,9	neutral_metalloendopeptidase	13,41	SCH 39370	neutral metalloendopeptidase	MESH:C060631	24590(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	SCH_39370 , a neutral_metalloendopeptidase inhibitor , potentiates biological responses to atrial_natriuretic_factor and lowers blood pressure in desoxycorticosterone_acetate-sodium hypertensive rats .
24486705	0	SCH_412348	60,70	adenosine_A2A_receptor	25,47	SCH 412348	adenosine A2A receptor	MESH:C534887	11540(Tax:10090)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Effects of the selective adenosine_A2A_receptor antagonist , SCH_412348 , on the parkinsonian phenotype of MitoPark mice .
8512660	0	SCH_42495	66,75	Atrial_natriuretic_factor	0,25	SCH 42495	Atrial natriuretic factor	MESH:C069018	24602(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|dobj|effects	Atrial_natriuretic_factor potentiating and hemodynamic effects of SCH_42495 , a new , neutral metalloendopeptidase inhibitor .
1429978	0	SCH_42495	196,205	atriopeptidase	170,184	SCH 42495	atriopeptidase	MESH:C069018	4311	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	High-performance liquid chromatographic determination of N - -LSB- 2 -LRB- S -RRB- - -LRB- mercaptomethyl -RRB- -3 - -LRB- 2-methylphenyl -RRB- -1 - oxopropyl -RSB- - L-methionine , the active plasma metabolite of a prodrug atriopeptidase inhibitor -LRB- SCH_42495 -RRB- , using a thiol selective -LRB- Au/Hg -RRB- amperometric detector .
8512660	0	SCH_42495	66,75	metalloendopeptidase	92,112	SCH 42495	metalloendopeptidase	MESH:C069018	64517(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Atrial_natriuretic_factor potentiating and hemodynamic effects of SCH_42495 , a new , neutral metalloendopeptidase inhibitor .
19715408	0	SCH_530348	0,10	thrombin	25,33	SCH 530348	thrombin	MESH:C530299	2147	Chemical	Gene	START_ENTITY|dep|antagonist antagonist|compound|END_ENTITY	SCH_530348 : a novel oral thrombin receptor antagonist .
12834887	0	SCH_58261	0,9	adenosine_A2A_receptor	23,45	SCH 58261	adenosine A2A receptor	MESH:C098657	25369(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	SCH_58261 , a selective adenosine_A2A_receptor antagonist , decreases the haloperidol-enhanced proenkephalin mRNA expression in the rat striatum .
18558486	0	SCH_58261	67,76	adenosine_A2A_receptor	80,102	SCH 58261	adenosine A2A receptor	MESH:C098657	25369(Tax:10116)	Chemical	Gene	Design|nmod|START_ENTITY Design|nmod|antagonists antagonists|amod|END_ENTITY	Design , synthesis , and evaluation of fused heterocyclic analogs of SCH_58261 as adenosine_A2A_receptor antagonists .
18562199	0	SCH_58261	37,46	adenosine_A2A_receptor	71,93	SCH 58261	adenosine A2A receptor	MESH:C098657	25369(Tax:10116)	Chemical	Gene	derivatives|nmod|START_ENTITY derivatives|nmod|antagonists antagonists|amod|END_ENTITY	Biaryl and heteroaryl derivatives of SCH_58261 as potent and selective adenosine_A2A_receptor antagonists .
8897460	0	SCH_58261	48,57	adenosine_A2A_receptor	14,36	SCH 58261	adenosine A2A receptor	MESH:C098657	25369(Tax:10116)	Chemical	Gene	discriminates|compound|START_ENTITY discriminates|amod|END_ENTITY	The selective adenosine_A2A_receptor antagonist SCH_58261 discriminates between two different binding sites for -LSB- 3H -RSB- - CGS_21680 in the rat brain .
12834887	0	SCH_58261	0,9	proenkephalin	93,106	SCH 58261	proenkephalin	MESH:C098657	29237(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|compound|END_ENTITY	SCH_58261 , a selective adenosine_A2A_receptor antagonist , decreases the haloperidol-enhanced proenkephalin mRNA expression in the rat striatum .
17483693	0	SCH_58621	49,58	adenosine_A2A_receptor	15,37	SCH 58621	adenosine A2A receptor	null	25369(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|antagonist antagonist|amod|END_ENTITY	Effects of the adenosine_A2A_receptor antagonist SCH_58621 on cyclooxygenase-2 expression , glial activation , and brain-derived_neurotrophic_factor availability in a rat model of striatal_neurodegeneration .
17483693	0	SCH_58621	49,58	cyclooxygenase-2	62,78	SCH 58621	cyclooxygenase-2	null	29527(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effects of the adenosine_A2A_receptor antagonist SCH_58621 on cyclooxygenase-2 expression , glial activation , and brain-derived_neurotrophic_factor availability in a rat model of striatal_neurodegeneration .
17468933	0	SCH_79797	0,9	PAR1	23,27	SCH 79797	PAR1	MESH:C415424	25439(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	SCH_79797 , a selective PAR1 antagonist , limits myocardial_ischemia / reperfusion injury in rat hearts .
24900404	0	SCH_900229	13,23	Presenilin_1	34,46	SCH 900229	Presenilin 1	null	5663	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|compound|END_ENTITY	Discovery of SCH_900229 , a Potent Presenilin_1 Selective y-Secretase Inhibitor for the Treatment of Alzheimer 's _ Disease .
24900372	0	SCH_900271	13,23	Nicotinic_Acid_Receptor	34,57	SCH 900271	Nicotinic Acid Receptor	null	338442	Chemical	Gene	START_ENTITY|appos|Agonist Agonist|compound|END_ENTITY	Discovery of SCH_900271 , a Potent Nicotinic_Acid_Receptor Agonist for the Treatment of Dyslipidemia .
21285160	0	SCIO-469	102,110	p38	114,117	SCIO-469	p38	MESH:C499748	1432	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	A 24-week , randomized , double-blind , placebo-controlled , parallel group study of the efficacy of oral SCIO-469 , a p38 mitogen-activated protein kinase inhibitor , in patients with active rheumatoid_arthritis .
1989152	0	SC_45662	75,83	5-lipoxygenase	49,63	SC 45662	5-lipoxygenase	MESH:C066992	240	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Immunosuppressive properties of enisoprost and a 5-lipoxygenase inhibitor -LRB- SC_45662 -RRB- .
20227876	0	SD-0006	18,25	p38	65,68	SD-0006	p38	MESH:C545840	1432	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|MAP MAP|amod|END_ENTITY	Identification of SD-0006 , a potent diaryl_pyrazole inhibitor of p38 MAP kinase .
25747583	0	SD-208	0,6	Protein_Kinase_D	16,32	SD-208	Protein Kinase D	MESH:C511004	5587	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|compound|END_ENTITY	SD-208 , a Novel Protein_Kinase_D Inhibitor , Blocks Prostate Cancer Cell Proliferation and Tumor Growth In Vivo by Inducing G2/M Cell Cycle Arrest .
23144445	0	SD-6010	120,127	iNOS	91,95	SD-6010	iNOS	MESH:C578791	4843	Chemical	Gene	study|appos|START_ENTITY study|nmod|inhibitor inhibitor|compound|END_ENTITY	A 2-year randomised , double-blind , placebo-controlled , multicentre study of oral selective iNOS inhibitor , cindunistat -LRB- SD-6010 -RRB- , in patients with symptomatic osteoarthritis_of_the_knee .
19590255	0	SD0006	0,6	p38	62,65	SD0006	p38	MESH:C545840	81649(Tax:10116)	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|kinase kinase|amod|END_ENTITY	SD0006 : a potent , selective and orally available inhibitor of p38 kinase .
11495581	0	SDI	69,72	Sorbitol_dehydrogenase	0,22	SDI	Sorbitol dehydrogenase	null	24788(Tax:10116)	Chemical	Gene	inhibitors|dep|START_ENTITY inhibitors|amod|END_ENTITY	Sorbitol_dehydrogenase inhibitors -LRB- SDIs -RRB- : a new potent , enantiomeric SDI , 4 - -LSB- 2-1R-hydroxy-ethyl -RRB- - pyrimidin-4-yl -RSB- piperazine-1-sulfonic acid dimethylamide .
8624082	0	SDS	41,44	beta-amyloid_precursor_protein	69,99	SDS	beta-amyloid precursor protein	CHEBI:8984	351	Chemical	Gene	complex|compound|START_ENTITY complex|nmod|END_ENTITY	A novel brain cysteine protease forms an SDS stable complex with the beta-amyloid_precursor_protein .
8102935	0	SDZ_216-525	38,49	5-HT1A	10,16	SDZ 216-525	5-HT1A	MESH:C080378	24473(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|nummod|END_ENTITY	The novel 5-HT1A receptor antagonist , SDZ_216-525 , decreases 5-HT release in rat hippocampus in vivo .
14978259	0	SEA0400	11,18	NCX1	29,33	SEA0400	NCX1	MESH:C430918	6546	Chemical	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Effects of SEA0400 on mutant NCX1 .1 Na + - Ca2 + exchangers with altered ionic regulation .
24611843	0	SEW2871	20,27	sphingosine-1-phosphate_type_1_receptor	31,70	SEW2871	sphingosine-1-phosphate type 1 receptor	MESH:C503964	13609(Tax:10090)	Chemical	Gene	treatment|nmod|START_ENTITY treatment|appos|agonist agonist|amod|END_ENTITY	Oral treatment with SEW2871 , a sphingosine-1-phosphate_type_1_receptor agonist , ameliorates experimental colitis in interleukin-10 gene deficient mice .
23261525	0	SGI-1776	25,33	P-glycoprotein	71,85	SGI-1776	P-glycoprotein	MESH:C545188	5243	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|nmod|END_ENTITY	The Pim kinase inhibitor SGI-1776 decreases cell surface expression of P-glycoprotein -LRB- ABCB1 -RRB- and breast_cancer_resistance_protein -LRB- ABCG2 -RRB- and drug transport by Pim-1-dependent and - independent mechanisms .
25080901	0	SGI-1776	0,8	Pim-1	109,114	SGI-1776	Pim-1	MESH:C545188	5292	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	SGI-1776 , an imidazo pyridazine compound , inhibits the proliferation of ovarian_cancer cells by inactivating Pim-1 .
19934279	0	SGX523	0,6	receptor_tyrosine_kinase	73,97	SGX523	receptor tyrosine kinase	MESH:C547925	5979	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	SGX523 is an exquisitely selective , ATP-competitive inhibitor of the MET receptor_tyrosine_kinase with antitumor activity in vivo .
14677936	0	SH2	85,88	Itk	81,84	SH2	Itk	CHEBI:36945	3702	Chemical	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	Ligand specificity modulated by prolyl_imide bond Cis/Trans isomerization in the Itk SH2 domain : a quantitative NMR study .
10623804	0	SH2	141,144	SHP-2	135,140	SH2	SHP-2	CHEBI:36945	5781	Chemical	Gene	proteins|compound|START_ENTITY proteins|compound|END_ENTITY	Effects of Src homology domain 2 -LRB- SH2 -RRB- - containing inositol phosphatase -LRB- SHIP -RRB- , SH2-containing phosphotyrosine phosphatase -LRB- SHP -RRB- -1 , and SHP-2 SH2 decoy proteins on Fc gamma RIIB1-effector interactions and inhibitory functions .
12542415	0	SH2	68,71	SHP-2	82,87	SH2	SHP-2	CHEBI:36945	5781	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Molecular dynamics simulations on the free and complexed N-terminal SH2 domain of SHP-2 .
25779001	0	SH2	72,75	c-Abl	48,53	SH2	c-Abl	CHEBI:36945	25	Chemical	Gene	domain|compound|START_ENTITY END_ENTITY|nmod|domain	Crystal structure of an SH2-kinase construct of c-Abl and effect of the SH2 domain on kinase activity .
9271425	0	SH2-N	27,32	Shp-2	43,48	SH2-N	Shp-2	null	19247(Tax:10090)	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	A deletion mutation in the SH2-N domain of Shp-2 severely suppresses hematopoietic cell development .
10377387	0	SH2-bbeta	18,27	Janus_kinase_2	85,99	SH2-bbeta	Janus kinase 2	null	3717	Chemical	Gene	Identification|nmod|START_ENTITY kinase|nsubj|Identification kinase|dobj|END_ENTITY	Identification of SH2-bbeta as a potent cytoplasmic activator of the tyrosine kinase Janus_kinase_2 .
9175779	0	SH2_cysteine	57,69	myosin	87,93	SH2 cysteine	myosin	null	79784	Chemical	Gene	START_ENTITY|nmod|II II|compound|END_ENTITY	Modulation of actin filament sliding by mutations of the SH2_cysteine in Dictyostelium myosin II .
12833568	0	SH3	81,84	Abl	77,80	SH3	Abl	CHEBI:30489	25	Chemical	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	Reexamination of the recognition preference of the specificity pocket of the Abl SH3 domain .
11885979	0	SH3	96,99	Grb2	80,84	SH3	Grb2	CHEBI:30489	14784(Tax:10090)	Chemical	Gene	domain|compound|START_ENTITY domain|amod|END_ENTITY	Solution structure of N-terminal SH3 domain of Vav and the recognition site for Grb2 C-terminal SH3 domain .
24105423	0	SH3	87,90	Grb2	71,75	SH3	Grb2	CHEBI:30489	2885	Chemical	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	Conformational change of Sos-derived proline-rich peptide upon binding Grb2 N-terminal SH3 domain probed by NMR .
10512753	0	SH3	45,48	Src	41,44	SH3	Src	CHEBI:30489	6714	Chemical	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	Critical amino_acid substitutions in the Src SH3 domain that convert c-Src to be oncogenic .
11127814	0	SH3	48,51	Src	63,66	SH3	Src	CHEBI:30489	20779(Tax:10090)	Chemical	Gene	domains|nummod|START_ENTITY domains|nmod|END_ENTITY	Meltrin alpha cytoplasmic domain interacts with SH3 domains of Src and Grb2 and is phosphorylated by v-Src .
8761480	0	SH3	4,7	Src	18,21	SH3	Src	CHEBI:30489	83805(Tax:10116)	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	The SH3 domain of Src tyrosyl protein_kinase interacts with the N-terminal splice region of the PDE4A cAMP-specific phosphodiesterase RPDE-6 -LRB- RNPDE4A5 -RRB- .
10683262	0	SH3	23,26	myosin-IC	50,59	SH3	myosin-IC	CHEBI:30489	4641	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Acan125 binding to the SH3 domain of acanthamoeba myosin-IC .
14660555	0	SH4	15,18	Fyn	51,54	SH4	Fyn	null	2534	Chemical	Gene	region|compound|START_ENTITY region|nmod|END_ENTITY	The N-terminal SH4 region of the Src family kinase Fyn is modified by methylation and heterogeneous fatty acylation : role in membrane targeting , cell adhesion , and spreading .
7685165	0	SHC	18,21	insulin_receptor	44,60	SHC	insulin receptor	null	100766818	Chemical	Gene	START_ENTITY|nmod|substrate substrate|nmod|END_ENTITY	Identification of SHC as a substrate of the insulin_receptor kinase distinct from the GAP-associated 62 kDa tyrosine phosphoprotein .
12970166	7	SHU91199	1058,1066	CRH	1085,1088	SHU91199	CRH	null	1392	Chemical	Gene	influence|nsubj|START_ENTITY influence|dobj|END_ENTITY	The nonselective melanocortin receptor blocker SHU91199 did not influence CRH - or TRH-induced TSH secretion .
26908461	0	SI113	0,5	SGK1	9,13	SI113	SGK1	null	6446	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	SI113 , a SGK1 inhibitor , potentiates the effects of radiotherapy , modulates the response to oxidative stress and induces cytotoxic autophagy in human glioblastoma multiforme cells .
25871776	0	SI113	0,5	Sgk1	35,39	SI113	Sgk1	null	6446	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|activity activity|amod|END_ENTITY	SI113 , a specific inhibitor of the Sgk1 kinase activity that counteracts cancer cell proliferation .
14704469	0	SIB_1893	13,21	mGluR5	35,41	SIB 1893	mGluR5	MESH:C120148	14805(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Influence of SIB_1893 , a selective mGluR5 receptor antagonist , on the anticonvulsant activity of conventional antiepileptic drugs in two models of experimental_epilepsy .
15520501	0	SIB_1893	0,8	mGluR5	22,28	SIB 1893	mGluR5	MESH:C120148	14805(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	SIB_1893 , a selective mGluR5 receptor antagonist , potentiates the anticonvulsant activity of oxcarbazepine against amygdala-kindled convulsions in rats .
17579621	0	SJG-136	151,158	ERCC1	63,68	SJG-136	ERCC1	MESH:C423343	2067	Chemical	Gene	contributes|dobj|START_ENTITY contributes|nsubj|END_ENTITY	Fludarabine-mediated suppression of the excision repair enzyme ERCC1 contributes to the cytotoxic synergy with the DNA minor groove crosslinking agent SJG-136 -LRB- NSC_694501 -RRB- in chronic_lymphocytic_leukaemia cells .
26282406	0	SJG-136	61,68	SG2000	53,59	SJG-136	SG2000	MESH:C423343	6922478(Tax:550538)	Chemical	Gene	Activity|appos|START_ENTITY Activity|nmod|END_ENTITY	Activity of the DNA minor groove cross-linking agent SG2000 -LRB- SJG-136 -RRB- against canine tumours .
26282406	0	SJG-136	61,68	SG2000	53,59	SJG-136	SG2000	MESH:C423343	6922478(Tax:550538)	Chemical	Gene	Activity|appos|START_ENTITY Activity|nmod|END_ENTITY	Activity of the DNA minor groove cross-linking agent SG2000 -LRB- SJG-136 -RRB- against canine tumours .
23018603	0	SK-1009	15,22	interleukin-6	34,47	SK-1009	interleukin-6	MESH:C581103	3569	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Novel compound SK-1009 suppresses interleukin-6 expression through modulation of activation of nuclear factor-kappaB pathway .
12793841	0	SK-896	47,53	motilin	67,74	SK-896	motilin	MESH:C414785	4295	Chemical	Gene	START_ENTITY|appos|analogue analogue|compound|END_ENTITY	Pharmacokinetic and pharmacodynamic studies of SK-896 , a new human motilin analogue , in healthy male volunteers .
9548387	0	SKF-82958	80,89	Fos	16,19	SKF-82958	Fos	MESH:C071262	314322(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY expression|acl|induced expression|compound|END_ENTITY	MK-801 reverses Fos expression induced by the full dopamine D1 receptor agonist SKF-82958 in the rat striatum .
21689106	0	SKF-83566	0,9	dopamine_transporter	59,79	SKF-83566	dopamine transporter	MESH:C044846	24898(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	SKF-83566 , a D1-dopamine receptor antagonist , inhibits the dopamine_transporter .
23383239	0	SKF-96365	22,31	Homer1	134,140	SKF-96365	Homer1	MESH:C063159	29546(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|role role|nmod|END_ENTITY	Protective effects of SKF-96365 , a non-specific inhibitor of SOCE , against MPP + - induced cytotoxicity in PC12 cells : potential role of Homer1 .
8904737	0	SKF29661	155,163	phenylethanolamine_N-methyltransferase	10,48	SKF29661	phenylethanolamine N-methyltransferase	MESH:C018428	24661(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|inhibitor inhibitor|amod|END_ENTITY	Effect of phenylethanolamine_N-methyltransferase inhibitor , CGS19281A , on the alpha-2-adrenoceptor function in the hypothalamus of rats in comparison with SKF29661 , SKF64139 and yohimbine .
24255811	0	SKF38393	31,39	Prolactin	0,9	SKF38393	Prolactin	MESH:D015647	100126745(Tax:9555)	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Prolactin and fMRI response to SKF38393 in the baboon .
6182406	0	SKF64139	33,41	phenylethanolamine_N-methyltransferase	45,83	SKF64139	phenylethanolamine N-methyltransferase	MESH:C012153	24661(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|inhibitor inhibitor|amod|END_ENTITY	Pre - and postsynaptic effects of SKF64139 , a phenylethanolamine_N-methyltransferase inhibitor , in conscious normotensive rats .
20957037	0	SKF83959	32,40	CA1	56,59	SKF83959	CA1	MESH:C080703	310218(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|neurons neurons|compound|END_ENTITY	Electrophysiological effects of SKF83959 on hippocampal CA1 pyramidal neurons : potential mechanisms for the drug 's neuroprotective effects .
7565623	0	SKF86002	47,55	interleukin-1_beta	14,32	SKF86002	interleukin-1 beta	MESH:C052026	3553	Chemical	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Inhibition of interleukin-1_beta production by SKF86002 : evidence of two sites of in vitro activity and of a time and system dependence .
16675111	0	SKF_38393	33,42	GAP-43	51,57	SKF 38393	GAP-43	MESH:D015647	100718025	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Dopaminergic D1 receptor agonist SKF_38393 induces GAP-43 expression and long-term potentiation in hippocampus in vivo .
18953088	0	SKF_38393	35,44	cFOS	55,59	SKF 38393	cFOS	MESH:D015647	314322(Tax:10116)	Chemical	Gene	increases|compound|START_ENTITY END_ENTITY|nsubj|increases	Dopamine D1-like receptors agonist SKF_38393 increases cFOS expression in the paraventricular nucleus of the hypothalamus -- impact of acute and chronic cocaine .
2147120	0	SKF_38393	110,119	dopamine_D1_receptor	80,100	SKF 38393	dopamine D1 receptor	MESH:D015647	1812	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Inhibition of low calcium induced epileptiform_discharges in the hippocampus by dopamine_D1_receptor agonist , SKF_38393 .
7902432	0	SKF_81297	75,84	Dopamine_D1_receptor	0,20	SKF 81297	Dopamine D1 receptor	MESH:C067113	1812	Chemical	Gene	effects|nmod|START_ENTITY involvement|nmod|effects involvement|amod|END_ENTITY	Dopamine_D1_receptor involvement in the discriminative-stimulus effects of SKF_81297 in squirrel monkeys .
8100193	0	SKF_81297	44,53	dopamine_D1_receptor	14,34	SKF 81297	dopamine D1 receptor	MESH:C067113	697796(Tax:9544)	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	The selective dopamine_D1_receptor agonist , SKF_81297 , stimulates motor behaviour of MPTP-lesioned monkeys .
16324697	0	SKF_83959	42,51	Fos	69,72	SKF 83959	Fos	MESH:C080703	314322(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	The atypical dopamine D1 receptor agonist SKF_83959 induces striatal Fos expression in rats .
12398155	0	SKF_91488	13,22	histamine_N-methyltransferase	24,53	SKF 91488	histamine N-methyltransferase	MESH:C024535	81676(Tax:10116)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|appos|inhibitor inhibitor|amod|END_ENTITY	Influence of SKF_91488 , histamine_N-methyltransferase inhibitor , on the central cardiovascular regulation during controlled , stepwise hemorrhagic_hypotension in rats .
25563902	0	SKI-178	83,90	Sphingosine_Kinase_1	41,61	SKI-178	Sphingosine Kinase 1	MESH:C556358	8877	Chemical	Gene	Inhibitor|appos|START_ENTITY Inhibitor|compound|END_ENTITY	The Apoptotic Mechanism of Action of the Sphingosine_Kinase_1 Selective Inhibitor , SKI-178 , in Human AML Cell Lines .
12543790	0	SKI-606	0,7	Src	63,66	SKI-606	Src	MESH:C471992	20779(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|kinases kinases|compound|END_ENTITY	SKI-606 , a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases , is a potent antiproliferative agent against chronic_myelogenous_leukemia cells in culture and causes regression of K562 xenografts in nude_mice .
18483306	0	SKI-606	0,7	Src	29,32	SKI-606	Src	MESH:C471992	6714	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	SKI-606 -LRB- bosutinib -RRB- , a novel Src kinase inhibitor , suppresses migration and invasion of human breast_cancer cells .
22271876	0	SKI-606	0,7	Src	12,15	SKI-606	Src	MESH:C471992	20779(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	SKI-606 , an Src inhibitor , reduces tumor growth , invasion , and distant metastasis in a mouse model of thyroid_cancer .
24695082	0	SKI-606	165,172	Src	151,154	SKI-606	Src	MESH:C471992	20779(Tax:10090)	Chemical	Gene	START_ENTITY|amod|phenotype phenotype|nmod|inhibitor inhibitor|compound|END_ENTITY	Pro32Pro33 mutations in the integrin b3 PSI domain result in aIIbb3 priming and enhanced adhesion : reversal of the hypercoagulability phenotype by the Src inhibitor SKI-606 .
17147981	0	SKL-2841	0,8	MCP-1	31,36	SKL-2841	MCP-1	null	17224(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|nmod|END_ENTITY	SKL-2841 , a dual antagonist of MCP-1 and MIP-1_beta , prevents bleomycin-induced skin_sclerosis in mice .
25030434	0	SKLB-287	0,8	EGFR	50,54	SKLB-287	EGFR	null	1956	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	SKLB-287 , a novel oral multikinase inhibitor of EGFR and VEGFR2 , exhibits potent antitumor activity in LoVo colorectal_tumor model .
15705904	8	SL0101	1041,1047	RSK	1057,1060	SL0101	RSK	MESH:C497449	6196	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Interestingly , SL0101 does not alter proliferation of a normal human breast cell line MCF-10A , although SL0101 inhibits RSK in these cells .
15705904	8	SL0101	952,958	RSK	1057,1060	SL0101	RSK	MESH:C497449	6196	Chemical	Gene	alter|nsubj|START_ENTITY alter|advcl|inhibits inhibits|dobj|END_ENTITY	Interestingly , SL0101 does not alter proliferation of a normal human breast cell line MCF-10A , although SL0101 inhibits RSK in these cells .
16723233	0	SL0101	53,59	RSK	97,100	SL0101	RSK	MESH:C497449	6196	Chemical	Gene	potency|nmod|START_ENTITY substituents|nmod|potency Influence|nmod|substituents END_ENTITY|nsubj|Influence	Influence of rhamnose substituents on the potency of SL0101 , an inhibitor of the Ser/Thr kinase , RSK .
22846040	0	SL0101	92,98	RSK	61,64	SL0101	RSK	MESH:C497449	6197	Chemical	Gene	Insights|nmod|START_ENTITY Insights|nmod|kinase kinase|appos|END_ENTITY	Insights into the inhibition of the p90 ribosomal S6 kinase -LRB- RSK -RRB- by the flavonol_glycoside SL0101 from the 1.5 crystal structure of the N-terminal domain of RSK2 with bound inhibitor .
23519677	0	SL0101	26,32	RSK	37,40	SL0101	RSK	MESH:C497449	6197	Chemical	Gene	affinity|nmod|START_ENTITY Improving|dobj|affinity Improving|advcl|using using|nsubj|END_ENTITY	Improving the affinity of SL0101 for RSK using structure-based design .
21074569	0	SL327	72,77	ERK	53,56	SL327	ERK	MESH:C424127	26413(Tax:10090)	Chemical	Gene	activity|nmod|START_ENTITY activity|appos|END_ENTITY	Inhibition of extracellular_signal-regulated_kinase -LRB- ERK -RRB- activity with SL327 does not prevent acquisition , expression , and extinction of ethanol-seeking behavior in mice .
21074569	0	SL327	72,77	extracellular_signal-regulated_kinase	14,51	SL327	extracellular signal-regulated kinase	MESH:C424127	26413(Tax:10090)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Inhibition of extracellular_signal-regulated_kinase -LRB- ERK -RRB- activity with SL327 does not prevent acquisition , expression , and extinction of ethanol-seeking behavior in mice .
18207393	0	SLV-319	162,169	CB1	180,183	SLV-319	CB1	MESH:C482795	1268	Chemical	Gene	START_ENTITY|dep|antagonist antagonist|compound|END_ENTITY	Bioisosteric replacement of dihydropyrazole of 4S - -LRB- - -RRB- -3 - -LRB- 4-chlorophenyl -RRB- - N-methyl-N ' - -LSB- -LRB- 4-chlorophenyl -RRB- - sulfonyl -RSB- -4 - phenyl-4 ,5 - dihydro-1H-pyrazole-1-caboxamidine -LRB- SLV-319 -RRB- a potent CB1 receptor antagonist by imidazole and oxazole .
15726334	0	SLV-323	10,17	NK1_receptor	27,39	SLV-323	NK1 receptor	null	6869	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Examining SLV-323 , a novel NK1_receptor antagonist , in a chronic psychosocial stress model for depression .
20132903	0	SLV330	0,6	CB1	22,25	SLV330	CB1	MESH:C551035	25248(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	SLV330 , a cannabinoid CB1 receptor antagonist , ameliorates deficits in the T-maze , object recognition and Social Recognition Tasks in rodents .
11287764	0	SM-12502	39,47	Platelet-activating_factor	0,26	SM-12502	Platelet-activating factor	MESH:C065776	300795(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Platelet-activating_factor antagonist , SM-12502 , attenuates experimental glomerular thrombosis in rats .
8070898	2	SM-15178	249,257	LTB4	272,276	SM-15178	LTB4	MESH:C089134	100135572(Tax:10141)	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|dobj|END_ENTITY	SM-15178 inhibited -LSB- 3H -RSB- LTB4 binding to its receptors on human neutrophils -LRB- IC50 = 0.30 microM -RRB- .
21372226	0	SM-164	91,97	TRAIL	118,123	SM-164	TRAIL	MESH:C533467	8743	Chemical	Gene	potential|nmod|START_ENTITY potential|nmod|END_ENTITY	Therapeutic potential and molecular mechanism of a novel , potent , nonpeptide , Smac mimetic SM-164 in combination with TRAIL for cancer treatment .
1970610	0	SM-3997	49,56	5-HT1A	62,68	SM-3997	5-HT1A	MESH:C055267	24473(Tax:10116)	Chemical	Gene	interaction|nmod|START_ENTITY evidence|nmod|interaction evidence|nmod|receptors receptors|nummod|END_ENTITY	Autoradiographic evidence for the interaction of SM-3997 with 5-HT1A receptors in the rat brain .
1971265	0	SM-3997	43,50	5-HT1A	27,33	SM-3997	5-HT1A	MESH:C055267	3350	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	The clinical efficacy of a 5-HT1A agonist , SM-3997 , in the treatment of bulimia .
198170	0	SM220CL	66,73	beta1/beta2-adrenoceptor	26,50	SM220CL	beta1/beta2-adrenoceptor	null	100722663	Chemical	Gene	selectivity|nmod|START_ENTITY selectivity|amod|END_ENTITY	Species difference in the beta1/beta2-adrenoceptor selectivity of SM220CL in the cat and guinea-pig .
22165967	0	SMA-ZnPP	21,29	CD38	105,109	SMA-ZnPP	CD38	MESH:C518727	952	Chemical	Gene	exert|nsubj|START_ENTITY exert|nmod|END_ENTITY	The Hsp32 inhibitors SMA-ZnPP and PEG-ZnPP exert major growth-inhibitory effects on D34 + / CD38 + and CD34 + / CD38 - AML progenitor cells .
22008853	0	SMK-17	88,94	MEK1/2	70,76	SMK-17	MEK1/2	MESH:C572760	5604;5605	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Antitumor effects of novel highly hydrophilic and non-ATP-competitive MEK1/2 inhibitor , SMK-17 .
6148524	0	SMS_201-995	91,102	growth_hormone	41,55	SMS 201-995	growth hormone	MESH:D015282	2688	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|suppression suppression|nmod|END_ENTITY	Long-acting and selective suppression of growth_hormone secretion by somatostatin analogue SMS_201-995 in acromegaly .
25361765	0	SMTP-7	89,95	Soluble_Epoxide_Hydrolase	0,25	SMTP-7	Soluble Epoxide Hydrolase	MESH:C409191	2053	Chemical	Gene	Target|nmod|START_ENTITY END_ENTITY|nmod|Target	Soluble_Epoxide_Hydrolase as an Anti-inflammatory Target of the Thrombolytic_Stroke Drug SMTP-7 .
11688982	0	SN-38	45,50	ABCG2	88,93	SN-38	ABCG2	MESH:C051890	9429	Chemical	Gene	Transport|appos|START_ENTITY Transport|nmod|END_ENTITY	Transport of 7-ethyl-10-hydroxycamptothecin -LRB- SN-38 -RRB- by breast_cancer_resistance_protein ABCG2 in human lung_cancer cells .
15075385	0	SN-38	42,47	ABCG2	0,5	SN-38	ABCG2	MESH:C051890	9429	Chemical	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	ABCG2 mediates differential resistance to SN-38 -LRB- 7-ethyl-10-hydroxycamptothecin -RRB- and homocamptothecins .
16542215	0	SN-38	65,70	ABCG2	8,13	SN-38	ABCG2	MESH:C051890	9429	Chemical	Gene	predicting|nmod|START_ENTITY Role|acl|predicting Role|nmod|END_ENTITY	Role of ABCG2 as a biomarker for predicting resistance to CPT-11 / SN-38 in lung_cancer .
18929442	0	SN-38	31,36	Akt	14,17	SN-38	Akt	MESH:C051890	207	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Inhibition of Akt signaling by SN-38 induces apoptosis in cervical_cancer .
11507714	0	SN-38	110,115	CPT-11	155,161	SN-38	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	activity|nmod|START_ENTITY assay|nmod|activity assay|appos|END_ENTITY	High-performance liquid chromatographic assay for glucuronidation activity of 7-ethyl-10-hydroxycamptothecin -LRB- SN-38 -RRB- , the active metabolite of irinotecan -LRB- CPT-11 -RRB- , in human liver microsomes .
11901092	0	SN-38	93,98	CPT-11	27,33	SN-38	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	irinotecan|appos|START_ENTITY irinotecan|appos|END_ENTITY	Interaction of irinotecan -LRB- CPT-11 -RRB- and its active metabolite 7-ethyl-10-hydroxycamptothecin -LRB- SN-38 -RRB- with human cytochrome_P450 enzymes .
12485959	0	SN-38	51,56	CPT-11	95,101	SN-38	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	Glucuronidation|nmod|START_ENTITY Glucuronidation|appos|END_ENTITY	Glucuronidation of 7-ethyl-10-hydroxycamptothecin -LRB- SN-38 -RRB- , an active metabolite of irinotecan -LRB- CPT-11 -RRB- , by human UGT1A1 variants , G71R , P229Q , and Y486D .
1329748	0	SN-38	99,104	CPT-11	130,136	SN-38	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	START_ENTITY|appos|metabolite metabolite|nmod|END_ENTITY	Camptothecin analog -LRB- CPT-11 -RRB- - sensitive human pancreatic_tumor cell line QGP-1N shows resistance to SN-38 , an active metabolite of CPT-11 .
14583489	0	SN-38	143,148	CPT-11	133,139	SN-38	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	deliver|nmod|START_ENTITY deliver|nmod|cells cells|nmod|conversion conversion|nmod|END_ENTITY	A prodrug strategy using ONYX-015-based replicating adenoviruses to deliver rabbit carboxylesterase to tumor cells for conversion of CPT-11 to SN-38 .
15809721	0	SN-38	59,64	CPT-11	84,90	SN-38	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	START_ENTITY|appos|form form|nmod|END_ENTITY	Blocking of PI3K/Akt pathway enhances apoptosis induced by SN-38 , an active form of CPT-11 , in human hepatoma cells .
16182400	0	SN-38	20,25	CPT-11	50,56	SN-38	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	Liposomalization|nmod|START_ENTITY Liposomalization|nmod|END_ENTITY	Liposomalization of SN-38 as active metabolite of CPT-11 .
1651156	0	SN-38	23,28	CPT-11	109,115	SN-38	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	roles|nmod|START_ENTITY roles|nmod|effect effect|nmod|END_ENTITY	Intracellular roles of SN-38 , a metabolite of the camptothecin derivative CPT-11 , in the antitumor effect of CPT-11 .
1651156	0	SN-38	23,28	CPT-11	74,80	SN-38	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	roles|nmod|START_ENTITY roles|appos|metabolite metabolite|nmod|END_ENTITY	Intracellular roles of SN-38 , a metabolite of the camptothecin derivative CPT-11 , in the antitumor effect of CPT-11 .
18761148	0	SN-38	176,181	CPT-11	141,147	SN-38	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	metabolite|appos|START_ENTITY utilizing|dep|metabolite utilizing|dep|END_ENTITY	Development and validation of reversed phase liquid chromatographic method utilizing ultraviolet detection for quantification of irinotecan -LRB- CPT-11 -RRB- and its active metabolite , SN-38 , in rat plasma and bile samples : application to pharmacokinetic studies .
24494988	0	SN-38	79,84	CPT-11	53,59	SN-38	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	irinotecan|amod|START_ENTITY irinotecan|appos|END_ENTITY	Macromolecular prodrug that provides the irinotecan -LRB- CPT-11 -RRB- active-metabolite SN-38 with ultralong half-life , low C -LRB- max -RRB- , and low glucuronide formation .
26526067	0	SN-38	109,114	CPT-11	137,143	SN-38	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	START_ENTITY|appos|Metabolite Metabolite|nmod|END_ENTITY	Organic_Anion_Transporting_Polypeptide -LRB- OATP -RRB- 2B1 Contributes to Gastrointestinal Toxicity of Anticancer Drug SN-38 , Active Metabolite of CPT-11 .
7737901	0	SN-38	83,88	CPT-11	50,56	SN-38	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	START_ENTITY|nsubj|analysis analysis|nmod|END_ENTITY	A pharmacokinetic and pharmacodynamic analysis of CPT-11 and its active metabolite SN-38 .
7961127	0	SN-38	53,58	CPT-11	84,90	SN-38	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	cytotoxicity|nmod|START_ENTITY enhancement|amod|cytotoxicity enhancement|appos|metabolite metabolite|nmod|END_ENTITY	Synergistic enhancement of cisplatin cytotoxicity by SN-38 , an active metabolite of CPT-11 , for cisplatin-resistant HeLa cells .
8060134	0	SN-38	21,26	CPT-11	43,49	SN-38	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|form form|nmod|END_ENTITY	-LSB- Antitumor effect of SN-38 , active form of CPT-11 , on human colorectal_cancer cell line -RSB- .
8340259	0	SN-38	70,75	CPT-11	101,107	SN-38	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	START_ENTITY|appos|metabolite metabolite|nmod|END_ENTITY	Relationship between development of diarrhea and the concentration of SN-38 , an active metabolite of CPT-11 , in the intestine and the blood plasma of athymic mice following intraperitoneal administration of CPT-11 .
8340259	0	SN-38	70,75	CPT-11	207,213	SN-38	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	Relationship|nmod|START_ENTITY Relationship|nmod|administration administration|nmod|END_ENTITY	Relationship between development of diarrhea and the concentration of SN-38 , an active metabolite of CPT-11 , in the intestine and the blood plasma of athymic mice following intraperitoneal administration of CPT-11 .
8515576	0	SN-38	57,62	CPT-11	23,29	SN-38	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Cytogenetic effects of CPT-11 and its active metabolite , SN-38 on human lymphocytes .
8548021	0	SN-38	104,109	CPT-11	69,75	SN-38	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	irinotecan|appos|START_ENTITY irinotecan|appos|END_ENTITY	High-performance liquid chromatographic determination of irinotecan -LRB- CPT-11 -RRB- and its active metabolite -LRB- SN-38 -RRB- in human plasma .
8831730	0	SN-38	92,97	CPT-11	26,32	SN-38	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	7-ethyl-10-hydroxycamptothecin|dep|START_ENTITY Conversion|amod|7-ethyl-10-hydroxycamptothecin Conversion|nmod|irinotecan irinotecan|appos|END_ENTITY	Conversion of irinotecan -LRB- CPT-11 -RRB- to its active metabolite , 7-ethyl-10-hydroxycamptothecin -LRB- SN-38 -RRB- , by human_liver_carboxylesterase .
9054955	0	SN-38	81,86	CPT-11	132,138	SN-38	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	cells|nmod|START_ENTITY apoptosis|nmod|cells Induction|nmod|apoptosis Induction|appos|metabolite metabolite|nmod|END_ENTITY	Induction of apoptosis in multi-drug resistant -LRB- MDR -RRB- human glioblastoma cells by SN-38 , a metabolite of the camptothecin derivative CPT-11 .
9192967	0	SN-38	0,5	CPT-11	51,57	SN-38	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	START_ENTITY|appos|metabolite metabolite|nmod|END_ENTITY	SN-38 , a metabolite of the camptothecin derivative CPT-11 , potentiates the cytotoxic effect of radiation in human colon_adenocarcinoma cells grown as spheroids .
9255427	0	SN-38	99,104	CPT-11	144,150	SN-38	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	forms|nmod|START_ENTITY determination|nmod|forms determination|appos|END_ENTITY	Simultaneous determination of the lactone and carboxylate forms of 7-ethyl-10-hydroxycamptothecin -LRB- SN-38 -RRB- , the active metabolite of irinotecan -LRB- CPT-11 -RRB- , in rat plasma by high performance liquid chromatography .
9272733	0	SN-38	67,72	CPT-11	34,40	SN-38	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	transformation|nmod|START_ENTITY transformation|appos|END_ENTITY	The transformation of irinotecan -LRB- CPT-11 -RRB- to its active metabolite SN-38 by human liver microsomes .
9331983	0	SN-38	102,107	CPT-11	124,130	SN-38	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	administration|nmod|START_ENTITY SN-38|nmod|administration pharmacokinetics|nmod|SN-38 pharmacokinetics|appos|END_ENTITY	Plasma pharmacokinetics of 7-ethyl-10-hydroxycamptothecin -LRB- SN-38 -RRB- after intravenous administration of SN-38 and irinotecan -LRB- CPT-11 -RRB- to rats .
9331983	0	SN-38	59,64	CPT-11	124,130	SN-38	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY pharmacokinetics|appos|END_ENTITY	Plasma pharmacokinetics of 7-ethyl-10-hydroxycamptothecin -LRB- SN-38 -RRB- after intravenous administration of SN-38 and irinotecan -LRB- CPT-11 -RRB- to rats .
9655905	0	SN-38	104,109	CPT-11	38,44	SN-38	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	properties|nmod|START_ENTITY Identification|dep|properties Identification|nmod|metabolite metabolite|nmod|END_ENTITY	Identification of a new metabolite of CPT-11 -LRB- irinotecan -RRB- : pharmacological properties and activation to SN-38 .
9789606	1	SN-38	153,158	CPT-11	108,114	SN-38	UGT1A1	MESH:C051890	54658	Chemical	Gene	form|dobj|START_ENTITY metabolized|xcomp|form metabolized|nsubjpass|Irinotecan Irinotecan|appos|END_ENTITY	BACKGROUND : Irinotecan -LRB- CPT-11 -RRB- is metabolized by esterase to form a SN-38 , which is further conjugated by UGT1A1 .
9845096	0	SN-38	11,16	CPT-11	42,48	SN-38	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|dep|metabolite metabolite|nmod|END_ENTITY	Effects of SN-38 -LRB- an active metabolite of CPT-11 -RRB- on responses of human and rodent cells to irradiation .
9865925	0	SN-38	43,48	CPT-11	18,24	SN-38	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	APC|nmod|START_ENTITY APC|nsubj|Conversion Conversion|nmod|metabolite metabolite|compound|END_ENTITY	Conversion of the CPT-11 metabolite APC to SN-38 by rabbit liver_carboxylesterase .
19417717	0	SN-38	65,70	S-1	34,37	SN-38	S-1	MESH:C051890	5707	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of oral administration of S-1 on the pharmacokinetics of SN-38 , irinotecan active metabolite , in patients with advanced colorectal_cancer .
9789606	0	SN-38	40,45	UGT1A1	0,6	SN-38	UGT1A1	MESH:C051890	54658	Chemical	Gene	genotypes|nmod|START_ENTITY genotypes|compound|END_ENTITY	UGT1A1 genotypes and glucuronidation of SN-38 , the active metabolite of irinotecan .
24995161	0	SN33638	16,23	AKR1C3	41,47	SN33638	AKR1C3	null	8644	Chemical	Gene	Activity|nmod|START_ENTITY Activity|appos|Inhibitor Inhibitor|nmod|END_ENTITY	The Activity of SN33638 , an Inhibitor of AKR1C3 , on Testosterone and 17b-Estradiol Production and Function in Castration-Resistant Prostate Cancer and ER-Positive Breast_Cancer .
24132143	0	SN38	68,72	ATP_citrate_lyase	0,17	SN38	ATP citrate lyase	MESH:C051890	47	Chemical	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	ATP_citrate_lyase mediates resistance of colorectal_cancer cells to SN38 .
15583935	0	SN38	27,31	hypoxia-inducible_factor_1_alpha	81,113	SN38	hypoxia-inducible factor 1 alpha	MESH:C051890	3091	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|inhibition inhibition|nmod|END_ENTITY	Anti-angiogenic effects of SN38 -LRB- active metabolite of irinotecan -RRB- : inhibition of hypoxia-inducible_factor_1_alpha -LRB- HIF-1alpha -RRB- / vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression of glioma and growth of endothelial cells .
22665525	0	SN38	105,109	p53	113,116	SN38	p53	MESH:C051890	7157	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Pharmacogenomic profiling and pathway analyses identify MAPK-dependent migration as an acute response to SN38 in p53 null and p53-mutant colorectal_cancer cells .
24881957	0	SNAP_37889	33,43	Galanin-3_receptor	0,18	SNAP 37889	Galanin-3 receptor	MESH:C510288	29235(Tax:10116)	Chemical	Gene	antagonism|nmod|START_ENTITY antagonism|amod|END_ENTITY	Galanin-3_receptor antagonism by SNAP_37889 reduces motivation to self-administer alcohol and attenuates cue-induced reinstatement of alcohol-seeking in iP rats .
20736033	0	SNAP_37889	35,45	galanin-3_receptor	4,22	SNAP 37889	galanin-3 receptor	MESH:C510288	29235(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	The galanin-3_receptor antagonist , SNAP_37889 , reduces operant responding for ethanol in alcohol-preferring rats .
1916543	0	SNB-5001	46,54	erythropoietin	30,44	SNB-5001	erythropoietin	null	2056	Chemical	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of recombinant human erythropoietin -LRB- SNB-5001 -RRB- on renal anemic rats induced by drugs -RSB- .
8831778	0	SNF_9007	204,212	CCK-B	269,274	SNF 9007	CCK-B	MESH:C085990	887	Chemical	Gene	Nle-Asp-Phe-NH2|appos|START_ENTITY use|dep|Nle-Asp-Phe-NH2 analogue|nsubj|use analogue|nmod|receptors receptors|amod|END_ENTITY	The use of topographical constraints in receptor mapping : investigation of the topographical requirements of the tryptophan 30 residue for receptor binding of Asp-Tyr-D-Phe-Gly-Trp - -LRB- N-Me -RRB- Nle-Asp-Phe-NH2 -LRB- SNF_9007 -RRB- , a cholecystokinin -LRB- 26-33 -RRB- analogue that binds to both CCK-B and delta-opioid receptors .
10065760	8	SNO	1680,1683	P-selectin	1647,1657	SNO	P-selectin	CHEBI:65308	6403	Chemical	Gene	induced|nmod|START_ENTITY expression|acl|induced expression|amod|END_ENTITY	WEB_2086 -LRB- 10 microM -RRB- , a PAF receptor antagonist , blocked neutrophil adhesion , but did not block P-selectin expression induced by SNO .
14608356	0	SNP	12,15	SLC22A4	43,50	SNP	SLC22A4	null	30805(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|site site|nmod|END_ENTITY	An intronic SNP in a RUNX1 binding site of SLC22A4 , encoding an organic cation transporter , is associated with rheumatoid_arthritis .
16239061	0	SNP309	27,33	MDM2	22,26	SNP309	MDM2	null	4193	Chemical	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	No association of the MDM2 SNP309 polymorphism with risk of breast or ovarian_cancer .
21051533	0	SNP309	19,25	MDM2	14,18	SNP309	MDM2	null	17246(Tax:10090)	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|compound|END_ENTITY	TP53 R72P and MDM2 SNP309 polymorphisms and colorectal_cancer risk : the Fukuoka Colorectal_Cancer Study .
26926790	0	SNP309	26,32	MDM2	46,50	SNP309	MDM2	null	4193	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Homozygous G/G variant of SNP309 in the human MDM2 gene is associated with earlier tumor onset in Caucasian female renal_cell_carcinoma patients .
20479412	0	SNS-032	35,42	Cdk2	67,71	SNS-032	Cdk2	MESH:C484864	1017	Chemical	Gene	I|nmod|START_ENTITY I|appos|END_ENTITY	Phase I and pharmacologic study of SNS-032 , a potent and selective Cdk2 , 7 , and 9 inhibitor , in patients with advanced chronic_lymphocytic_leukemia and multiple_myeloma .
18948577	0	SNX-2112	0,8	Hsp90	22,27	SNX-2112	Hsp90	MESH:C534922	3320	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	SNX-2112 , a selective Hsp90 inhibitor , potently inhibits tumor cell growth , angiogenesis , and osteoclastogenesis in multiple_myeloma and other hematologic_tumors by abrogating signaling via Akt and ERK .
20675090	0	SNX-2112	17,25	Hsp90	39,44	SNX-2112	Hsp90	MESH:C534922	299331(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Determination of SNX-2112 , a selective Hsp90 inhibitor , in plasma samples by high-performance liquid chromatography and its application to pharmacokinetics in rats .
21227627	0	SNX-2112	40,48	Hsp90	58,63	SNX-2112	Hsp90	MESH:C534922	299331(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Preclinical pharmacokinetic analysis of SNX-2112 , a novel Hsp90 inhibitor , in rats .
21821931	0	SNX-2112	0,8	Hsp90	18,23	SNX-2112	Hsp90	MESH:C534922	3320	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	SNX-2112 , a novel Hsp90 inhibitor , induces G2/M cell cycle arrest and apoptosis in MCF-7 cells .
22182451	0	SNX-2112	0,8	Hsp90	13,18	SNX-2112	Hsp90	MESH:C534922	3320	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	SNX-2112 , an Hsp90 inhibitor , induces apoptosis and autophagy via degradation of Hsp90 client proteins in human melanoma A-375 cells .
22182451	0	SNX-2112	0,8	Hsp90	81,86	SNX-2112	Hsp90	MESH:C534922	3320	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|apoptosis apoptosis|nmod|degradation degradation|nmod|proteins proteins|amod|END_ENTITY	SNX-2112 , an Hsp90 inhibitor , induces apoptosis and autophagy via degradation of Hsp90 client proteins in human melanoma A-375 cells .
25936860	0	SNX-2112	113,121	Hsp90	125,130	SNX-2112	Hsp90	MESH:C534922	111058(Tax:10090)	Chemical	Gene	delivery|nmod|START_ENTITY carriers|nmod|delivery nanospheres|nmod|carriers nanospheres|appos|inhibitor inhibitor|amod|END_ENTITY	Phospholipid-stabilized mesoporous carbon nanospheres as versatile carriers for systemic delivery of amphiphobic SNX-2112 -LRB- a Hsp90 inhibitor -RRB- with enhanced antitumor effect .
25262379	0	SNX-5422	35,43	heat_shock_protein_90	68,89	SNX-5422	heat shock protein 90	null	3320	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Phase I dose-escalation studies of SNX-5422 , an orally bioavailable heat_shock_protein_90 inhibitor , in patients with refractory solid tumours .
18172276	0	SNX2112	0,7	heat_shock_protein_90	21,42	SNX2112	heat shock protein 90	MESH:C534922	104408(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	SNX2112 , a synthetic heat_shock_protein_90 inhibitor , has potent antitumor activity against HER_kinase-dependent_cancers .
25011056	0	SOM230	22,28	adrenocorticotropic_hormone	32,59	SOM230	adrenocorticotropic hormone	MESH:C517782	18976(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|production production|amod|END_ENTITY	Inhibitory effects of SOM230 on adrenocorticotropic_hormone production and corticotroph tumor cell proliferation in vitro and in vivo .
24741075	0	SOMG-833	0,8	c-MET	28,33	SOMG-833	c-MET	null	4233	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	SOMG-833 , a novel selective c-MET inhibitor , blocks c-MET-dependent neoplastic effects and exerts antitumor activity .
11854436	0	SP500263	62,70	estrogen_receptor	97,114	SP500263	estrogen receptor	MESH:C448221	2099	Chemical	Gene	START_ENTITY|appos|modulator modulator|compound|END_ENTITY	Differential response of estrogen_receptors alpha and beta to SP500263 , a novel potent selective estrogen_receptor modulator .
14627919	0	SP600125	41,49	C-jun_N-terminal_kinase	0,23	SP600125	C-jun N-terminal kinase	MESH:C432165	5599	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	C-jun_N-terminal_kinase -LRB- JNK -RRB- inhibitor , SP600125 , blocks interleukin _ -LRB- IL -RRB- -6 - induced vascular_endothelial_growth_factor -LRB- VEGF -RRB- production : cyclosporine_A partially mimics this inhibitory effect .
16644485	0	SP600125	14,22	COX-2	31,36	SP600125	COX-2	MESH:C432165	19225(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|compound|END_ENTITY	JNK inhibitor SP600125 reduces COX-2 expression by attenuating mRNA in activated murine J774 macrophages .
12878189	0	SP600125	0,8	CREB	61,65	SP600125	CREB	MESH:C432165	12912(Tax:10090)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	SP600125 , an inhibitor of c-jun_N-terminal_kinase , activates CREB by a p38_MAPK-mediated pathway .
15454338	0	SP600125	22,30	ERK1/2	116,122	SP600125	ERK1/2	MESH:C432165	5595;5594	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|inhibitor inhibitor|nmod|kinase kinase|appos|END_ENTITY	Protective effects of SP600125 a new inhibitor of c-jun N-terminal kinase -LRB- JNK -RRB- and extracellular-regulated kinase -LRB- ERK1/2 -RRB- in an experimental model of cerulein-induced pancreatitis .
14627919	0	SP600125	41,49	JNK	25,28	SP600125	JNK	MESH:C432165	5599	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|appos|END_ENTITY	C-jun_N-terminal_kinase -LRB- JNK -RRB- inhibitor , SP600125 , blocks interleukin _ -LRB- IL -RRB- -6 - induced vascular_endothelial_growth_factor -LRB- VEGF -RRB- production : cyclosporine_A partially mimics this inhibitory effect .
14741394	0	SP600125	0,8	JNK	16,19	SP600125	JNK	MESH:C432165	26419(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	SP600125 , a new JNK inhibitor , protects dopaminergic neurons in the MPTP model of Parkinson 's _ disease .
15454338	0	SP600125	22,30	JNK	75,78	SP600125	JNK	MESH:C432165	26419(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|inhibitor inhibitor|nmod|kinase kinase|appos|END_ENTITY	Protective effects of SP600125 a new inhibitor of c-jun N-terminal kinase -LRB- JNK -RRB- and extracellular-regulated kinase -LRB- ERK1/2 -RRB- in an experimental model of cerulein-induced pancreatitis .
15528336	0	SP600125	98,106	JNK	124,127	SP600125	JNK	MESH:C432165	5599	Chemical	Gene	lymphocytes|nmod|START_ENTITY lymphocytes|appos|inhibitor inhibitor|nmod|END_ENTITY	Rescuing melanoma epitope-specific cytolytic T lymphocytes from activation-induced cell death , by SP600125 , an inhibitor of JNK : implications in cancer immunotherapy .
15713276	0	SP600125	30,38	JNK	59,62	SP600125	JNK	MESH:C432165	116554(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	The neuroprotective action of SP600125 , a new inhibitor of JNK , on transient brain_ischemia / reperfusion-induced neuronal_death in rat hippocampal CA1 via nuclear and non-nuclear pathways .
15919053	7	SP600125	908,916	JNK	918,921	SP600125	p38	MESH:C432165	5594	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	However , SB203580 -LRB- p38 inhibitor -RRB- and SP600125 -LRB- JNK inhibitor -RRB- showed little effect on the migration .
16630028	0	SP600125	27,35	JNK	13,16	SP600125	JNK	MESH:C432165	26419(Tax:10090)	Chemical	Gene	tumour|compound|START_ENTITY tumour|compound|END_ENTITY	The specific JNK inhibitor SP600125 targets tumour necrosis factor-alpha production and epithelial cell apoptosis in acute murine colitis .
16953120	0	SP600125	0,8	JNK	22,25	SP600125	JNK	MESH:C432165	26419(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	SP600125 , a selective JNK inhibitor , aggravates hepatic_ischemia-reperfusion injury .
17459422	0	SP600125	0,8	JNK	22,25	SP600125	JNK	MESH:C432165	5599	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	SP600125 , a selective JNK inhibitor , protects ischemic_renal_injury via suppressing the extrinsic pathways of apoptosis .
18174237	6	SP600125	1118,1126	JNK	1103,1106	SP600125	JNK	MESH:C432165	5599	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Pretreatment of Sup-T1 cells with a specific JNK inhibitor , SP600125 , also increased the Bim -LRB- EL -RRB- level and resensitized the cells to etoposide-induced apoptosis .
19206150	0	SP600125	110,118	JNK	0,3	SP600125	JNK	MESH:C432165	5599	Chemical	Gene	active|nmod|START_ENTITY active|nsubj|END_ENTITY	JNK is constitutively active in mantle_cell_lymphoma : cell cycle deregulation and polyploidy by JNK inhibitor SP600125 .
19517066	5	SP600125	1128,1136	JNK	1045,1048	SP600125	JNK	MESH:C432165	5599	Chemical	Gene	concentration|nmod|START_ENTITY inhibited|nmod|concentration inhibited|nsubjpass|phosphorylation phosphorylation|nmod|c-Jun c-Jun|compound|END_ENTITY	The phosphorylation of the JNK target protein c-Jun , but not of ATF-2 , was inhibited by this concentration of SP600125 .
19522739	7	SP600125	1242,1250	JNK	1252,1255	SP600125	ERK	MESH:C432165	5594	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Treatment with MAPK inhibitors , PD98059 -LRB- ERK inhibitor -RRB- , SP600125 -LRB- JNK inhibitor -RRB- and SB202190 -LRB- p38 inhibitor -RRB- , confirmed that melatonin-induced apoptosis was JNK - and p38-dependent , but ERK-independent .
20062077	0	SP600125	0,8	JNK	92,95	SP600125	JNK	MESH:C432165	5599	Chemical	Gene	suppresses|compound|START_ENTITY Cdk1|nsubj|suppresses Cdk1|xcomp|independent independent|nmod|inhibition inhibition|compound|END_ENTITY	SP600125 suppresses Cdk1 and induces endoreplication directly from G2 phase , independent of JNK inhibition .
20600246	0	SP600125	0,8	JNK	37,40	SP600125	JNK	MESH:C432165	116554(Tax:10116)	Chemical	Gene	attenuates|advmod|START_ENTITY attenuates|nsubj|inhibitor inhibitor|nmod|END_ENTITY	SP600125 , a competitive inhibitor of JNK attenuates streptozotocin induced neurocognitive_deficit and oxidative stress in rats .
22940059	4	SP600125	762,770	JNK	772,775	SP600125	p38	MESH:C432165	5594	Chemical	Gene	p38|dep|START_ENTITY SB203580|dep|p38 SB203580|dep|END_ENTITY	When the activity of MAPKs was blocked by their corresponding inhibitors -LRB- SB203580 : p38 ; U0126 : ERK ; SP600125 : JNK -RRB- , the expression of TF was reduced significantly .
23210245	0	SP600125	0,8	JNK	12,15	SP600125	JNK	MESH:C432165	5599	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	SP600125 , a JNK inhibitor , suppresses growth of JNK-inactive glioblastoma cells through cell-cycle G2/M phase arrest .
23405080	7	SP600125	1526,1534	JNK	1512,1515	SP600125	p38	MESH:C432165	5594	Chemical	Gene	transfection|amod|START_ENTITY suppressed|nsubj|transfection inhibitor|acl:relcl|suppressed inhibitor|compound|END_ENTITY	Additionally , the specific JNK inhibitor SP600125 or JNK-specific small interference RNA -LRB- si-RNA -RRB- transfection suppressed Cd-induced b-cell apoptosis and related signals , but not ERK1/2 and p38-MAPK inhibitors -LRB- PD98059 and SB203580 -RRB- did not .
24103647	0	SP600125	19,27	JNK	4,7	SP600125	JNK	MESH:C432165	26419(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	The JNK inhibitor , SP600125 , potentiates the glial response and cell death induced by methamphetamine in the mouse striatum .
25226534	0	SP600125	0,8	JNK	76,79	SP600125	JNK	MESH:C432165	5599	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|Src Src|acl:relcl|IGF IGF|dobj|independent independent|nmod|END_ENTITY	SP600125 induces Src and type I IGF receptor phosphorylation independent of JNK .
25542238	2	SP600125	373,381	JNK	358,361	SP600125	JNK	MESH:C432165	5599	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|appos|END_ENTITY	This study investigated the effects of c-Jun_N-terminal_kinase -LRB- JNK -RRB- inhibitor SP600125 , acetylcholine -LRB- Ach -RRB- , etanercept , and anti-TNF-a on cellular apoptosis in the cerebral cortex and the hippocampus , in order to establish the role of JNK and TNF-a in EBI .
22068148	0	SP600125	0,8	JNK1/2	51,57	SP600125	JNK1/2	MESH:C432165	5599;5601	Chemical	Gene	replication|compound|START_ENTITY replication|nmod|END_ENTITY	SP600125 inhibits Orthopoxviruses replication in a JNK1/2 - independent manner : Implication as a potential antipoxviral .
24496382	9	SP600125	1229,1237	JNK1/2	1211,1217	SP600125	COL1A1	MESH:C432165	1277	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	The JNK1/2 inhibitor -LRB- SP600125 -RRB- abolished CH-induced COL1A1 expression .
25033895	6	SP600125	1242,1250	JNK1/2	1269,1275	SP600125	ERK1/2	MESH:C432165	5595;5594	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|pathway pathway|compound|END_ENTITY	Furthermore , MCP-1-induced secretion of MMP-9 was inhibited by U0126 -LRB- inhibitor of the ERK_1 / 2 pathway -RRB- and SB203580 -LRB- inhibitor of the p38 MAPK pathway -RRB- , but not SP600125 -LRB- inhibitor of the JNK1/2 pathway -RRB- .
19607816	0	SP600125	0,8	Jnk	26,29	SP600125	Jnk	MESH:C432165	5599	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|pathway pathway|compound|END_ENTITY	SP600125 , an inhibitor of Jnk pathway , reduces viability of relatively resistant cancer cells to doxorubicin .
11717429	0	SP600125	0,8	Jun_N-terminal_kinase	43,64	SP600125	Jun N-terminal kinase	MESH:C432165	5599	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	SP600125 , an anthrapyrazolone inhibitor of Jun_N-terminal_kinase .
25226534	0	SP600125	0,8	Src	17,20	SP600125	Src	MESH:C432165	6714	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	SP600125 induces Src and type I IGF receptor phosphorylation independent of JNK .
24375967	0	SP600125	128,136	TrkA	111,115	SP600125	TrkA	MESH:C432165	4914	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|activity activity|compound|END_ENTITY	Proteomic analysis of SP600125-controlled TrkA-dependent targets in SK-N-MC neuroblastoma cells : inhibition of TrkA activity by SP600125 .
17519787	0	SP600125	57,65	c-Jun_N-terminal_kinase	97,120	SP600125	c-Jun N-terminal kinase	MESH:C432165	116554(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Suppression of alloreactivity and allograft rejection by SP600125 , a small molecule inhibitor of c-Jun_N-terminal_kinase .
21263197	0	SP600125	0,8	c-Jun_N-terminal_kinase	65,88	SP600125	c-Jun N-terminal kinase	MESH:C432165	26419(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|translation translation|nmod|pathway pathway|amod|END_ENTITY	SP600125 inhibits cap-dependent translation independently of the c-Jun_N-terminal_kinase pathway .
15627438	0	SP600125	104,112	c-Jun_NH2-terminal_kinase	18,43	SP600125	c-Jun NH2-terminal kinase	MESH:C432165	26419(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY role|dep|effects role|nmod|END_ENTITY	Potential role of c-Jun_NH2-terminal_kinase in allergic airway_inflammation and remodelling : effects of SP600125 .
20490773	0	SP600125	0,8	c-Jun_NH2-terminal_kinase	26,51	SP600125	c-Jun NH2-terminal kinase	MESH:C432165	5599	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	SP600125 , an inhibitor of c-Jun_NH2-terminal_kinase , blocks expression of angiotensin_II-induced monocyte_chemoattractant_protein-1 in human mesangial cells .
12878189	0	SP600125	0,8	c-jun_N-terminal_kinase	26,49	SP600125	c-jun N-terminal kinase	MESH:C432165	26419(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	SP600125 , an inhibitor of c-jun_N-terminal_kinase , activates CREB by a p38_MAPK-mediated pathway .
16449644	0	SP600125	71,79	low-density_lipoprotein_receptor	24,56	SP600125	low-density lipoprotein receptor	MESH:C432165	3949	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Selective repression of low-density_lipoprotein_receptor expression by SP600125 : coupling of histone H3-Ser10 phosphorylation and Sp1 occupancy .
15868905	0	SPI-077	96,103	tumor_necrosis_factor-alpha	19,46	SPI-077	tumor necrosis factor-alpha	MESH:C422270	24835(Tax:10116)	Chemical	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of low-dose tumor_necrosis_factor-alpha in combination with STEALTH liposomal cisplatin -LRB- SPI-077 -RRB- on soft-tissue - and osteosarcoma-bearing rats .
1517528	0	SPR-901	98,105	interleukin_2	32,45	SPR-901	interleukin 2	MESH:C065495	16183(Tax:10090)	Chemical	Gene	Augmentation|nmod|START_ENTITY Augmentation|nmod|production production|amod|END_ENTITY	Augmentation of mitogen-induced interleukin_2 production by oral administration of polysaccharide SPR-901 .
6259216	0	SQ_14225	10,18	angiotensin_I-converting_enzyme	36,67	SQ 14225	angiotensin I-converting enzyme	null	11421(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|inhibitor inhibitor|nmod|END_ENTITY	Effect of SQ_14225 , an inhibitor of angiotensin_I-converting_enzyme , on the granulomatous response to Schistosoma_mansoni eggs in mice .
2407571	0	SQ_14225	58,66	angiotensin_I_converting_enzyme	15,46	SQ 14225	angiotensin I converting enzyme	null	24310(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	-LSB- The effect of angiotensin_I_converting_enzyme inhibitor -LRB- SQ_14225 -RRB- on plasma 18-hydroxycorticosterone and aldosterone in sodium depleted conscious rats -RSB- .
7592897	0	SQ_20006	32,40	p70S6k	82,88	SQ 20006	p70S6k	MESH:C011610	6198	Chemical	Gene	blocks|nsubj|START_ENTITY blocks|dobj|activation activation|nmod|END_ENTITY	The phosphodiesterase inhibitor SQ_20006 selectively blocks mitogen activation of p70S6k and transition to S phase of the cell division cycle without affecting the steady state phosphorylation of eIF-4E .
198054	0	SQ_20881	57,65	angiotensin_I_converting_enzyme	14,45	SQ 20881	angiotensin I converting enzyme	MESH:D013722	100009274(Tax:9986)	Chemical	Gene	effect|appos|START_ENTITY effect|nmod|inhibitor inhibitor|amod|END_ENTITY	The effect of angiotensin_I_converting_enzyme inhibitor -LRB- SQ_20881 -RRB- on the release of prostaglandins by rabbit kidney , in vivo .
10322900	0	SR-140333	10,19	neurokinin-1_receptor	23,44	SR-140333	neurokinin-1 receptor	MESH:C085215	24807(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|antagonist antagonist|amod|END_ENTITY	Effect of SR-140333 , a neurokinin-1_receptor antagonist , on airway reactivity to methacholine in sedated rats .
16261315	0	SR-141716A	50,60	CB1	26,29	SR-141716A	CB1	MESH:C089032	25248(Tax:10116)	Chemical	Gene	antagonist|dobj|START_ENTITY antagonist|nsubj|Effect Effect|nmod|receptor receptor|compound|END_ENTITY	Effect of the cannabinoid CB1 receptor antagonist SR-141716A on ethanol self-administration and ethanol-seeking behaviour in rats .
11413237	0	SR-142948A	94,104	neurotensin	11,22	SR-142948A	neurotensin	MESH:C104418	299757(Tax:10116)	Chemical	Gene	revealed|nmod|START_ENTITY accumbens|advcl|revealed accumbens|nsubj|efflux efflux|compound|END_ENTITY	Endogenous neurotensin down-regulates dopamine efflux in the nucleus accumbens as revealed by SR-142948A , a selective neurotensin receptor antagonist .
11413237	0	SR-142948A	94,104	neurotensin	118,129	SR-142948A	neurotensin	MESH:C104418	299757(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Endogenous neurotensin down-regulates dopamine efflux in the nucleus accumbens as revealed by SR-142948A , a selective neurotensin receptor antagonist .
16380602	8	SR-202	906,912	PPARgamma	926,935	SR-202	PPARalpha	MESH:C051602	5465	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Cell demise was attenuated by SR-202 , a synthetic PPARgamma antagonist , and specificity was further verified by excluding a proapoptotic response to a PPARalpha agonist .
19751965	0	SR13179	176,183	MMP-2	86,91	SR13179	MMP-2	MESH:C548062	4313	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|activity activity|compound|END_ENTITY	Increase in tissue_inhibitor_of_metalloproteinase-2 -LRB- TIMP-2 -RRB- levels and inhibition of MMP-2 activity in a metastatic breast_cancer cell line by an anti-invasive small molecule SR13179 .
19633434	0	SR13904	69,76	peroxisome_proliferator-activated_receptor_delta	8,56	SR13904	peroxisome proliferator-activated receptor delta	MESH:C549080	5467	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	A novel peroxisome_proliferator-activated_receptor_delta antagonist , SR13904 , has anti-proliferative activity in human cancer cells .
16788306	0	SR140333	28,36	ERK	64,67	SR140333	ERK	MESH:C085215	24338(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|phosphorylation phosphorylation|compound|END_ENTITY	The NK1_receptor antagonist SR140333 inhibits capsaicin-induced ERK phosphorylation in sensory neurons .
14501258	0	SR140333	100,108	NK1_receptor	74,86	SR140333	NK1 receptor	MESH:C085215	21336(Tax:10090)	Chemical	Gene	reduces|dobj|START_ENTITY reduces|iobj|concentration concentration|nmod|substance_P substance_P|appos|END_ENTITY	P-Glycoprotein efflux reduces the brain concentration of the substance_P -LRB- NK1_receptor -RRB- antagonists SR140333 and GR205171 : a comparative study using mdr1a - / - and mdr1a + / + mice .
9523190	0	SR140333	11,19	NK1_receptor	45,57	SR140333	NK1 receptor	MESH:C085215	24807(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Effects of SR140333 , a selective non-peptide NK1_receptor antagonist , on trigemino-thalamic nociceptive pathways in the rat .
10063935	0	SR140333	0,8	substance_P_receptor	12,32	SR140333	substance P receptor	MESH:C085215	24807(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	SR140333 , a substance_P_receptor antagonist , influences morphological and motor changes in rat experimental colitis .
12644592	0	SR141716	40,48	Acrp30	59,65	SR141716	Acrp30	MESH:C089032	246253(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	The cannabinoid CB1 receptor antagonist SR141716 increases Acrp30 mRNA expression in adipose tissue of obese fa/fa rats and in cultured adipocyte cells .
11605080	0	SR141716	0,8	CB1	12,15	SR141716	CB1	MESH:C089032	25248(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	SR141716 , a CB1 receptor antagonist , decreases the sensitivity to the reinforcing effects of electrical brain stimulation in rats .
11821028	0	SR141716	82,90	CB1	57,60	SR141716	CB1	MESH:C089032	574142(Tax:9544)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	Evaluation of the reinforcing effects of the cannabinoid CB1 receptor antagonist , SR141716 , in rhesus_monkeys .
12399252	0	SR141716	23,31	CB1	35,38	SR141716	CB1	MESH:C089032	12801(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|antagonist antagonist|compound|END_ENTITY	Anti-obesity effect of SR141716 , a CB1 receptor antagonist , in diet-induced obese mice .
12690115	0	SR141716	129,137	CB1	113,116	SR141716	CB1	MESH:C089032	1268	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	Hypersensitization of the Orexin_1_receptor by the CB1 receptor : evidence for cross-talk blocked by the specific CB1 antagonist , SR141716 .
12690115	0	SR141716	129,137	CB1	51,54	SR141716	CB1	MESH:C089032	1268	Chemical	Gene	antagonist|appos|START_ENTITY blocked|nmod|antagonist cross-talk|acl|blocked evidence|nmod|cross-talk Hypersensitization|dep|evidence Hypersensitization|nmod|Orexin_1_receptor Orexin_1_receptor|nmod|receptor receptor|compound|END_ENTITY	Hypersensitization of the Orexin_1_receptor by the CB1 receptor : evidence for cross-talk blocked by the specific CB1 antagonist , SR141716 .
14694354	0	SR141716	65,73	CB1	28,31	SR141716	CB1	MESH:C089032	12801(Tax:10090)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	Blockade by the cannabinoid CB1 receptor antagonist , rimonabant -LRB- SR141716 -RRB- , of the potentiation by quinelorane of food-primed reinstatement of food-seeking behavior .
15292905	0	SR141716	176,184	CB1	138,141	SR141716	CB1	MESH:C089032	25248(Tax:10116)	Chemical	Gene	rimonabant|appos|START_ENTITY antagonist|appos|rimonabant antagonist|appos|END_ENTITY	Nicotine-associated cues maintain nicotine-seeking behavior in rats several weeks after nicotine withdrawal : reversal by the cannabinoid -LRB- CB1 -RRB- receptor antagonist , rimonabant -LRB- SR141716 -RRB- .
15936882	0	SR141716	51,59	CB1	26,29	SR141716	CB1	MESH:C089032	25248(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	Effect of the cannabinoid CB1 receptor antagonist , SR141716 , on nociceptive response and nerve demyelination in rodents with chronic constriction_injury_of_the_sciatic_nerve .
15994087	0	SR141716	175,183	CB1	57,60	SR141716	CB1	MESH:C089032	12801(Tax:10090)	Chemical	Gene	methyl-1H-pyrazole-3-carboxamide|appos|START_ENTITY Synthesis|dep|methyl-1H-pyrazole-3-carboxamide Synthesis|nmod|analogs analogs|nmod|N N|compound|END_ENTITY	Synthesis of long-chain amide analogs of the cannabinoid CB1 receptor antagonist N - -LRB- piperidinyl -RRB- -5 - -LRB- 4-chlorophenyl -RRB- -1 - -LRB- 2,4-dichlorophenyl -RRB- -4 - methyl-1H-pyrazole-3-carboxamide -LRB- SR141716 -RRB- with unique binding selectivities and pharmacological activities .
16282221	0	SR141716	52,60	CB1	16,19	SR141716	CB1	MESH:C089032	12801(Tax:10090)	Chemical	Gene	rimonabant|appos|START_ENTITY rimonabant|compound|END_ENTITY	The cannabinoid CB1 receptor antagonist rimonabant -LRB- SR141716 -RRB- inhibits cell proliferation and increases markers of adipocyte maturation in cultured mouse 3T3 F442A preadipocytes .
16822929	0	SR141716	52,60	CB1	16,19	SR141716	CB1	MESH:C089032	1268	Chemical	Gene	rimonabant|appos|START_ENTITY rimonabant|compound|END_ENTITY	The cannabinoid CB1 receptor antagonist rimonabant -LRB- SR141716 -RRB- inhibits human breast_cancer cell proliferation through a lipid raft-mediated mechanism .
18585913	0	SR141716	182,190	CB1	201,204	SR141716	CB1	MESH:C089032	1268	Chemical	Gene	methyl-1H-pyrazole-3-carboxylic_acid_piperidin-1-ylamide|appos|START_ENTITY methyl-1H-pyrazole-3-carboxylic_acid_piperidin-1-ylamide|dep|antagonist antagonist|compound|END_ENTITY	Facile synthesis , ex-vivo and in vitro screening of 3-sulfonamide derivative of 5 - -LRB- 4-chlorophenyl -RRB- -1 - -LRB- 2,4-dichlorophenyl -RRB- -4 - methyl-1H-pyrazole-3-carboxylic_acid_piperidin-1-ylamide -LRB- SR141716 -RRB- a potent CB1 receptor antagonist .
19679410	0	SR141716	31,39	CB1	4,7	SR141716	CB1	MESH:C089032	12801(Tax:10090)	Chemical	Gene	rimonabant|appos|START_ENTITY rimonabant|compound|END_ENTITY	The CB1 antagonist rimonabant -LRB- SR141716 -RRB- blocks cue-induced reinstatement of cocaine seeking and other context and extinction phenomena predictive of relapse .
21470203	0	SR141716	53,61	CB1	16,19	SR141716	CB1	MESH:C089032	373759(Tax:8355)	Chemical	Gene	rimonabant|appos|START_ENTITY antagonists|dobj|rimonabant antagonists|nsubj|receptor receptor|compound|END_ENTITY	The cannabinoid CB1 receptor antagonists rimonabant -LRB- SR141716 -RRB- and AM251 directly potentiate GABA -LRB- A -RRB- receptors .
26008966	0	SR141716	100,108	CB1	21,24	SR141716	CB1	MESH:C089032	1268	Chemical	Gene	responsiveness|nmod|START_ENTITY treatment|amod|responsiveness dictates|dobj|treatment regulates|ccomp|dictates regulates|nsubj|END_ENTITY	Cannabinoid receptor CB1 regulates STAT3 activity and its expression dictates the responsiveness to SR141716 treatment in human glioma patients ' cells .
15558076	0	SR141716	51,59	Lep	126,129	SR141716	Lep	MESH:C089032	16846(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|dep|END_ENTITY	Effects of the cannabinoid CB1 receptor antagonist SR141716 on oxygen consumption and soleus muscle glucose uptake in Lep -LRB- ob -RRB- / Lep -LRB- ob -RRB- mice .
10482905	0	SR141716A	41,50	CB1	16,19	SR141716A	CB1	MESH:C089032	25248(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	The cannabinoid CB1 receptor antagonist , SR141716A , selectively facilitates nociceptive responses of dorsal horn neurones in the rat .
10834304	0	SR141716A	25,34	CB1	40,43	SR141716A	CB1	MESH:C089032	25248(Tax:10116)	Chemical	Gene	treatment|nmod|START_ENTITY treatment|appos|antagonist antagonist|compound|END_ENTITY	Long-term treatment with SR141716A , the CB1 receptor antagonist , influences morphine withdrawal_syndrome .
11189200	0	SR141716A	0,9	CB1	67,70	SR141716A	CB1	MESH:C089032	25248(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|rats rats|nmod|that that|nmod|agonists agonists|compound|END_ENTITY	SR141716A induces in rats a behavioral pattern opposite to that of CB1 receptor agonists .
11447321	0	SR141716A	39,48	CB1	52,55	SR141716A	CB1	MESH:C089032	25248(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Anandamide-induced sleep is blocked by SR141716A , a CB1 receptor antagonist and by U73122 , a phospholipase C inhibitor .
12435794	0	SR141716A	97,106	CB1	193,196	SR141716A	CB1	MESH:C089032	1268	Chemical	Gene	interaction|appos|START_ENTITY N|dep|interaction crucial|nsubj|N crucial|nmod|agonism agonism|nmod|receptor receptor|compound|END_ENTITY	N - -LRB- piperidin-1-yl -RRB- -5 - -LRB- 4-chlorophenyl -RRB- -1 - -LRB- 2,4-dichlorophenyl -RRB- -4 - methyl-1H-pyrazole-3-carboxamide -LRB- SR141716A -RRB- interaction with LYS 3.28 -LRB- 192 -RRB- is crucial for its inverse agonism at the cannabinoid CB1 receptor .
14522359	0	SR141716A	0,9	CB1	25,28	SR141716A	CB1	MESH:C089032	25248(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	SR141716A , a cannabinoid CB1 receptor antagonist , improves memory in a delayed radial maze task .
16148442	0	SR141716A	119,128	CB1	12,15	SR141716A	CB1	MESH:C089032	12801(Tax:10090)	Chemical	Gene	antagonism|appos|START_ENTITY effect|nmod|antagonism role|dep|effect role|nmod|receptors receptors|nummod|END_ENTITY	The role of CB1 receptors in sweet versus fat reinforcement : effect of CB1 receptor deletion , CB1 receptor antagonism -LRB- SR141716A -RRB- and CB1 receptor agonism -LRB- CP-55940 -RRB- .
16148442	0	SR141716A	119,128	CB1	71,74	SR141716A	CB1	MESH:C089032	12801(Tax:10090)	Chemical	Gene	antagonism|appos|START_ENTITY antagonism|compound|END_ENTITY	The role of CB1 receptors in sweet versus fat reinforcement : effect of CB1 receptor deletion , CB1 receptor antagonism -LRB- SR141716A -RRB- and CB1 receptor agonism -LRB- CP-55940 -RRB- .
16148442	0	SR141716A	119,128	CB1	94,97	SR141716A	CB1	MESH:C089032	12801(Tax:10090)	Chemical	Gene	antagonism|appos|START_ENTITY antagonism|dep|END_ENTITY	The role of CB1 receptors in sweet versus fat reinforcement : effect of CB1 receptor deletion , CB1 receptor antagonism -LRB- SR141716A -RRB- and CB1 receptor agonism -LRB- CP-55940 -RRB- .
16533866	0	SR141716A	72,81	CB1	27,30	SR141716A	CB1	MESH:C089032	1268	Chemical	Gene	agonist|dobj|START_ENTITY agonist|nsubj|Effects Effects|nmod|receptor receptor|compound|END_ENTITY	Effects of the cannabinoid CB1 receptor agonist CP55 ,940 and antagonist SR141716A on d-amphetamine-induced behaviours in Cebus monkeys .
17392737	0	SR141716A	46,55	CB1	22,25	SR141716A	CB1	MESH:C089032	12801(Tax:10090)	Chemical	Gene	knockout|compound|START_ENTITY antagonist|dobj|knockout antagonist|nsubj|Effect Effect|nmod|receptor receptor|compound|END_ENTITY	Effect of cannabinoid CB1 receptor antagonist SR141716A and CB1 receptor knockout on cue-induced reinstatement of Ensure and corn-oil seeking in mice .
18599027	0	SR141716A	29,38	CB1	4,7	SR141716A	CB1	MESH:C089032	25248(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	The CB1 receptor antagonist , SR141716A , prevents high-frequency stimulation-induced reduction of feedback inhibition in the rat dentate gyrus following perforant path stimulation in vivo .
19207577	0	SR141716A	47,56	CB1	10,13	SR141716A	CB1	MESH:C089032	12801(Tax:10090)	Chemical	Gene	antagonist|appos|START_ENTITY attenuates|nsubj|antagonist cannabinoid|ccomp|attenuates cannabinoid|nsubj|END_ENTITY	Selective CB1 cannabinoid receptor antagonist , SR141716A , attenuates liver_injury induced by Concanavalin_A .
19575185	0	SR141716A	56,65	CB1	41,44	SR141716A	CB1	MESH:C089032	25248(Tax:10116)	Chemical	Gene	antagonist|dobj|START_ENTITY antagonist|nsubj|effects effects|nmod|END_ENTITY	Age-dependent effects of the cannabinoid CB1 antagonist SR141716A on food intake , body weight change , and pruritus in rats .
22995906	0	SR141716A	27,36	CB1	46,49	SR141716A	CB1	MESH:C089032	1268	Chemical	Gene	interaction|nmod|START_ENTITY Probing|dobj|interaction Probing|nmod|receptor receptor|compound|END_ENTITY	Probing the interaction of SR141716A with the CB1 receptor .
8739546	0	SR141716A	51,60	CB1	27,30	SR141716A	CB1	MESH:C089032	25248(Tax:10116)	Chemical	Gene	antagonist|dobj|START_ENTITY antagonist|nsubj|Effects Effects|nmod|receptor receptor|compound|END_ENTITY	Effects of the cannabinoid CB1 receptor antagonist SR141716A on the behavior of pigeons and rats .
8981483	0	SR141716A	57,66	CB1	38,41	SR141716A	CB1	MESH:C089032	25248(Tax:10116)	Chemical	Gene	using|dobj|START_ENTITY Characterisation|acl|using Characterisation|nmod|receptor receptor|compound|END_ENTITY	Characterisation of the rat cerebella CB1 receptor using SR141716A , a central cannabinoid receptor antagonist .
9346339	0	SR141716A	0,9	CB1	57,60	SR141716A	CB1	MESH:C089032	1268	Chemical	Gene	agonist|nsubj|START_ENTITY agonist|nmod|receptor receptor|compound|END_ENTITY	SR141716A is an inverse agonist at the human cannabinoid CB1 receptor .
9690851	0	SR141716A	32,41	CB1	75,78	SR141716A	CB1	MESH:C089032	1268	Chemical	Gene	Evidence|nmod|START_ENTITY Evidence|nmod|END_ENTITY	Evidence for inverse agonism of SR141716A at human recombinant cannabinoid CB1 and CB2 receptors .
9554803	0	SR142948A	0,9	neurotensin	66,77	SR142948A	neurotensin	MESH:C104418	4922	Chemical	Gene	antagonist|nsubj|START_ENTITY antagonist|nmod|effects effects|nmod|END_ENTITY	SR142948A is a potent antagonist of the cardiovascular effects of neurotensin .
12514329	0	SR144528	0,8	CB2	31,34	SR144528	CB2	MESH:C110630	1269	Chemical	Gene	START_ENTITY|nmod|agonist agonist|nmod|END_ENTITY	SR144528 as inverse agonist of CB2 cannabinoid receptor .
18804501	0	SR144528	38,46	mu-opioid_receptor	57,75	SR144528	mu-opioid receptor	MESH:C110630	18390(Tax:10090)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|amod|END_ENTITY	CB -LRB- 2 -RRB- cannabinoid receptor antagonist SR144528 decreases mu-opioid_receptor expression and activation in mouse brainstem : role of CB -LRB- 2 -RRB- receptor in pain .
12424552	0	SR146131	0,8	cholecystokinin-A_receptor	12,38	SR146131	cholecystokinin-A receptor	MESH:C118846	886	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	SR146131 , a cholecystokinin-A_receptor agonist , antagonizes prepulse inhibition deficits produced by dizocilpine and DOI .
15131245	0	SR147778	0,8	CB1	150,153	SR147778	CB1	MESH:C492668	1268	Chemical	Gene	-LSB-|compound|START_ENTITY -LSB-|appos|antagonist antagonist|nmod|receptor receptor|compound|END_ENTITY	SR147778 -LSB- 5 - -LRB- 4-bromophenyl -RRB- -1 - -LRB- 2,4-dichlorophenyl -RRB- -4 - ethyl-N - -LRB- 1-piperidinyl -RRB- -1 H-pyrazole-3-carboxamide -RSB- , a new potent and selective antagonist of the CB1 cannabinoid receptor : biochemical and pharmacological characterization .
15582988	0	SR147778	63,71	CB1	38,41	SR147778	CB1	MESH:C492668	25248(Tax:10116)	Chemical	Gene	effect|amod|START_ENTITY effect|nmod|receptor receptor|compound|END_ENTITY	Suppressing effect of the cannabinoid CB1 receptor antagonist , SR147778 , on alcohol intake and motivational properties of alcohol in alcohol-preferring sP rats .
17127132	0	SR147778	0,8	CB1	12,15	SR147778	CB1	MESH:C492668	25248(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	SR147778 , a CB1 cannabinoid receptor antagonist , suppresses ethanol preference in chronically alcoholized Wistar_rats .
8594316	0	SR48692	46,53	neurotensin	14,25	SR48692	neurotensin	MESH:C079087	299757(Tax:10116)	Chemical	Gene	antagonist|dobj|START_ENTITY antagonist|nsubj|Effect Effect|nmod|receptor receptor|compound|END_ENTITY	Effect of the neurotensin receptor antagonist SR48692 on rat blood pressure modulation by neurotensin .
8594316	0	SR48692	46,53	neurotensin	90,101	SR48692	neurotensin	MESH:C079087	299757(Tax:10116)	Chemical	Gene	antagonist|dobj|START_ENTITY antagonist|nmod|END_ENTITY	Effect of the neurotensin receptor antagonist SR48692 on rat blood pressure modulation by neurotensin .
9128997	0	SR48692	111,118	neurotensin	78,89	SR48692	neurotensin	MESH:C079087	4922	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	Inhibition of neurotensin-induced pancreatic_carcinoma growth by a nonpeptide neurotensin receptor antagonist , SR48692 .
9263204	0	SR48692	63,70	neurotensin	30,41	SR48692	neurotensin	MESH:C079087	4922	Chemical	Gene	diurnal|dep|START_ENTITY diurnal|compound|END_ENTITY	Central administration of the neurotensin receptor antagonist , SR48692 , modulates diurnal and stress-related hypothalamic-pituitary-adrenal_activity .
19388360	0	SR49059	72,79	V1a	47,50	SR49059	V1a	MESH:C082134	25107(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Modulation of AQP4 expression by the selective V1a receptor antagonist , SR49059 , decreases trauma-induced brain_edema .
10826575	0	SR49059	10,17	V1a_vasopressin_receptor	36,60	SR49059	V1a vasopressin receptor	MESH:C082134	552	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Effect of SR49059 , an orally active V1a_vasopressin_receptor antagonist , in the prevention of dysmenorrhoea .
12869559	0	SR49059	43,50	V1a_vasopressin_receptor	82,106	SR49059	V1a vasopressin receptor	MESH:C082134	552	Chemical	Gene	nonpeptide|compound|START_ENTITY sites|nmod|nonpeptide Identification|nmod|sites antagonist|nsubj|Identification antagonist|advcl|using using|nsubj|END_ENTITY	Identification of the binding sites of the SR49059 nonpeptide antagonist into the V1a_vasopressin_receptor using sulfydryl-reactive ligands and cysteine mutants as chemical sensors .
16325798	0	SR58611A	10,18	beta-3_adrenoceptor	29,48	SR58611A	beta-3 adrenoceptor	MESH:C076252	11556(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Effect of SR58611A , a potent beta-3_adrenoceptor agonist , on cutaneous wound healing in diabetic_and_obese mice .
21813867	0	SR59230A	0,8	beta-3_adrenoceptor	12,31	SR59230A	beta-3 adrenoceptor	MESH:C097869	25645(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	SR59230A , a beta-3_adrenoceptor antagonist , inhibits ultradian brown adipose tissue thermogenesis and interrupts associated episodic brain and body heating .
22470132	0	SRT1720	0,7	SIRT1	11,16	SRT1720	SIRT1	MESH:C525422	93759(Tax:10090)	Chemical	Gene	START_ENTITY|appos|activator activator|compound|END_ENTITY	SRT1720 , a SIRT1 activator , promotes tumor cell migration , and lung metastasis of breast_cancer in mice .
7510780	0	SR_140333	0,9	NK1	71,74	SR 140333	NK1	MESH:C085215	6869	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|nmod|receptor receptor|compound|END_ENTITY	SR_140333 , a novel , selective , and potent nonpeptide antagonist of the NK1 tachykinin receptor : characterization on the U373MG cell line .
10065938	0	SR_141716	0,9	CB1	13,16	SR 141716	CB1	MESH:C089032	1268	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	SR_141716 , a CB1 cannabinoid receptor antagonist , selectively reduces sweet food intake in marmoset .
12065194	0	SR_141716	136,145	CB1	111,114	SR 141716	CB1	MESH:C089032	25248(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	Boosting effect of morphine on alcohol drinking is suppressed not only by naloxone but also by the cannabinoid CB1 receptor antagonist , SR_141716 .
12632249	0	SR_141716	65,74	CB1	40,43	SR 141716	CB1	MESH:C089032	25248(Tax:10116)	Chemical	Gene	effects|appos|START_ENTITY effects|nmod|antagonist antagonist|compound|END_ENTITY	Preferential effects of the cannabinoid CB1 receptor antagonist , SR_141716 , on food intake and body weight_gain of obese -LRB- fa/fa -RRB- compared to lean Zucker rats .
15212978	0	SR_141716	92,101	CB1	67,70	SR 141716	CB1	MESH:C089032	12801(Tax:10090)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	Rapid tolerance to the intestinal prokinetic effect of cannabinoid CB1 receptor antagonist , SR_141716 -LRB- Rimonabant -RRB- .
15363985	0	SR_141716	63,72	CB1	38,41	SR 141716	CB1	MESH:C089032	25248(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	Suppressing effect of the cannabinoid CB1 receptor antagonist , SR_141716 , on alcohol 's motivational properties in alcohol-preferring rats .
8856836	0	SR_141716	87,96	CB1	50,53	SR 141716	CB1	MESH:C089032	1268	Chemical	Gene	antagonist|appos|START_ENTITY cannabinoid|dobj|antagonist cannabinoid|nsubj|Improvement Improvement|nmod|memory memory|nmod|rodents rodents|nmod|END_ENTITY	Improvement of memory in rodents by the selective CB1 cannabinoid receptor antagonist , SR_141716 .
9272766	0	SR_141716	54,63	CB1	103,106	SR 141716	CB1	MESH:C089032	25248(Tax:10116)	Chemical	Gene	Selective|nmod|START_ENTITY Selective|dobj|antagonist antagonist|nmod|receptors receptors|appos|END_ENTITY	Selective inhibition of sucrose and ethanol intake by SR_141716 , an antagonist of central cannabinoid -LRB- CB1 -RRB- receptors .
11224395	0	SR_141716A	82,92	CB1	66,69	SR 141716A	CB1	MESH:C089032	25248(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	Central mediation of the cannabinoid cue : activity of a selective CB1 antagonist , SR_141716A .
12957219	0	SR_141716A	57,67	CB1	33,36	SR 141716A	CB1	MESH:C089032	1268	Chemical	Gene	serotonin|compound|START_ENTITY antagonist|dobj|serotonin antagonist|nsubj|doses doses|nmod|receptor receptor|compound|END_ENTITY	Behaviorally active doses of the CB1 receptor antagonist SR_141716A increase brain serotonin and dopamine levels and turnover .
14665975	0	SR_141716A	32,42	CB1	16,19	SR 141716A	CB1	MESH:C089032	25248(Tax:10116)	Chemical	Gene	suppress|nsubj|START_ENTITY antagonists|ccomp|suppress antagonists|nsubj|END_ENTITY	The cannabinoid CB1 antagonists SR_141716A and AM_251 suppress food intake and food-reinforced behavior in a variety of tasks in rats .
8569415	0	SR_141716A	72,82	CB1	36,39	SR 141716A	CB1	MESH:C089032	25248(Tax:10116)	Chemical	Gene	cannabinoid|dobj|START_ENTITY cannabinoid|nsubj|properties properties|nmod|END_ENTITY	Arousal-enhancing properties of the CB1 cannabinoid receptor antagonist SR_141716A in rats as assessed by electroencephalographic spectral and sleep-waking cycle analysis .
8636122	0	SR_141716A	115,125	CB1	47,50	SR 141716A	CB1	MESH:C089032	1268	Chemical	Gene	the|nmod|START_ENTITY involved|nmod|the involved|nsubj|features features|nmod|receptor receptor|compound|END_ENTITY	Structural features of the central cannabinoid CB1 receptor involved in the binding of the specific CB1 antagonist SR_141716A .
8978752	0	SR_141716A	136,146	CB1	20,23	SR 141716A	CB1	MESH:C089032	25248(Tax:10116)	Chemical	Gene	using|dobj|START_ENTITY studies|acl|using Characterization|dep|studies Characterization|nmod|receptors receptors|nummod|END_ENTITY	Characterization of CB1 receptors on rat neuronal cell cultures : binding and functional studies using the selective receptor antagonist SR_141716A .
9855635	0	SR_141716A	0,10	CB1	112,115	SR 141716A	CB1	MESH:C089032	25248(Tax:10116)	Chemical	Gene	acts|nsubj|START_ENTITY acts|xcomp|increase increase|nmod|reversal reversal|nmod|activity activity|nummod|END_ENTITY	SR_141716A acts as an inverse agonist to increase neuronal voltage-dependent Ca2 + currents by reversal of tonic CB1 cannabinoid receptor activity .
7830490	0	SR_142801	0,9	NK3_receptor	69,81	SR 142801	NK3 receptor	MESH:C091554	100135627(Tax:10141)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|nmod|END_ENTITY	SR_142801 , the first potent non-peptide antagonist of the tachykinin NK3_receptor .
8751080	0	SR_142801	10,19	NK3_receptor	86,98	SR 142801	NK3 receptor	MESH:C091554	100135627(Tax:10141)	Chemical	Gene	START_ENTITY|nmod|responses responses|nmod|END_ENTITY	Effect of SR_142801 on nitric_oxide-dependent and independent responses to tachykinin NK3_receptor agonists in isolated guinea-pig colon .
18410947	0	SR_142948A	48,58	neurotensin	25,36	SR 142948A	neurotensin	MESH:C104418	67405(Tax:10090)	Chemical	Gene	antagonist|dobj|START_ENTITY antagonist|nsubj|Effects Effects|nmod|END_ENTITY	Effects of the selective neurotensin antagonist SR_142948A on 3,4-methylenedioxymethamphetamine-induced behaviours in mice .
9413022	0	SR_144190	46,55	NK2	93,96	SR 144190	NK2	MESH:C110304	6863	Chemical	Gene	START_ENTITY|appos|receptor receptor|compound|END_ENTITY	Biochemical and pharmacological activities of SR_144190 , a new potent non-peptide tachykinin NK2 receptor antagonist .
9454810	0	SR_144528	0,9	CB2	60,63	SR 144528	CB2	MESH:C110630	1269	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|nmod|receptor receptor|compound|END_ENTITY	SR_144528 , the first potent and selective antagonist of the CB2 cannabinoid receptor .
24704326	0	SR_21502	43,51	dopamine_D3_receptor	10,30	SR 21502	dopamine D3 receptor	null	29238(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	The novel dopamine_D3_receptor antagonist , SR_21502 , reduces cocaine conditioned place preference in rats .
26429728	0	SR_21502	47,55	dopamine_D3_receptor	14,34	SR 21502	dopamine D3 receptor	null	29238(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	The selective dopamine_D3_receptor antagonist , SR_21502 , reduces cue-induced reinstatement of heroin seeking and heroin conditioned place preference in rats .
26710978	0	SR_21502	37,45	dopamine_D3_receptor	4,24	SR 21502	dopamine D3 receptor	MESH:C000593313	29238(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	The dopamine_D3_receptor antagonist , SR_21502 , facilitates extinction of cocaine conditioned place preference .
9447704	0	SR_25989	23,31	thrombospondin-1	44,60	SR 25989	thrombospondin-1	MESH:C055162	7057	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Angiogenesis inhibitor SR_25989 upregulates thrombospondin-1 expression in human vascular endothelial cells and foreskin fibroblasts .
1817964	0	SR_27417	21,29	PAF	39,42	SR 27417	PAF	MESH:C071317	109585(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|antagonist antagonist|compound|END_ENTITY	Protective effect of SR_27417 , a novel PAF antagonist , on lethal anaphylactic and endotoxin-induced shock in mice .
2412015	0	SR_42128	92,100	renin	53,58	SR 42128	renin	MESH:C046599	5972	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	In vitro and in vivo inhibition of human and primate renin by a new potent renin inhibitor : SR_42128 .
2666612	0	SR_43845	30,38	renin	13,18	SR 43845	renin	MESH:C060501	5972	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Effects of a renin inhibitor , SR_43845 , and of captopril on blood pressure and plasma active renin in conscious sodium-replete macaca .
8149971	0	SR_47436	10,18	angiotensin_II	28,42	SR 47436	angiotensin II	MESH:C081309	183	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|antagonist antagonist|amod|END_ENTITY	Effect of SR_47436 , a novel angiotensin_II AT1 receptor antagonist , on human vascular smooth muscle cells in vitro .
7965724	0	SR_48527	89,97	neurotensin	25,36	SR 48527	neurotensin	MESH:C086487	100727527	Chemical	Gene	Effect|appos|START_ENTITY Effect|nmod|antagonist antagonist|compound|END_ENTITY	Effect of the nonpeptide neurotensin antagonist , SR_48692 , and two enantiomeric analogs , SR_48527 and SR_49711 , on neurotensin binding and contractile responses in guinea_pig ileum and colon .
11297813	0	SR_48692	27,35	Fos	76,79	SR 48692	Fos	MESH:C079087	314322(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|compound|END_ENTITY	The neurotensin antagonist SR_48692 attenuates haloperidol-induced striatal Fos expression in the rat .
11723247	7	SR_48692	925,933	NTR1	966,970	SR 48692	NTR2	MESH:C079087	23620	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|nmod|END_ENTITY	SR_48692 , a nonpeptide antagonist of the NTR1 , stimulated IP production , whereas levocabastine , a nonpeptide histamine H1 antagonist that binds the NTR2 but not the NTR1 , behaved as a weak partial inverse agonist .
10797539	0	SR_48692	121,129	neurotensin	18,29	SR 48692	neurotensin	MESH:C079087	299757(Tax:10116)	Chemical	Gene	treatment|nmod|START_ENTITY receptor|nmod|treatment NT|dobj|receptor NT|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of the neurotensin NT -LRB- 1 -RRB- receptor in the developing rat brain following chronic treatment with the antagonist SR_48692 .
11814639	0	SR_48692	117,125	neurotensin	93,104	SR 48692	neurotensin	MESH:C079087	299757(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	Stress-induced activation of median raphe serotonergic neurons in rats is potentiated by the neurotensin antagonist , SR_48692 .
7514773	0	SR_48692	52,60	neurotensin	111,122	SR 48692	neurotensin	MESH:C079087	299757(Tax:10116)	Chemical	Gene	receptors|nmod|START_ENTITY Blockade|nmod|receptors prevents|nsubj|Blockade prevents|dobj|transport transport|nmod|END_ENTITY	Blockade of neurotensin receptors by the antagonist SR_48692 partially prevents retrograde axonal transport of neurotensin in rat nigrostriatal system .
7514773	0	SR_48692	52,60	neurotensin	12,23	SR 48692	neurotensin	MESH:C079087	299757(Tax:10116)	Chemical	Gene	receptors|nmod|START_ENTITY receptors|compound|END_ENTITY	Blockade of neurotensin receptors by the antagonist SR_48692 partially prevents retrograde axonal transport of neurotensin in rat nigrostriatal system .
7541694	0	SR_48692	72,80	neurotensin	113,124	SR 48692	neurotensin	MESH:C079087	299757(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|nmod|receptor receptor|compound|END_ENTITY	Blockade of mast cell histamine secretion in response to neurotensin by SR_48692 , a nonpeptide antagonist of the neurotensin brain receptor .
7582445	0	SR_48692	13,21	neurotensin	98,109	SR 48692	neurotensin	MESH:C079087	299757(Tax:10116)	Chemical	Gene	Promotion|nmod|START_ENTITY Promotion|nmod|rats rats|acl|suggesting suggesting|dobj|role role|nmod|END_ENTITY	Promotion by SR_48692 of gastric emptying and defaecation in rats suggesting a role of endogenous neurotensin .
7716073	0	SR_48692	63,71	neurotensin	107,118	SR 48692	neurotensin	MESH:C079087	4922	Chemical	Gene	antagonist|appos|START_ENTITY effects|nmod|antagonist effects|nmod|effects effects|nmod|agonists agonists|compound|END_ENTITY	Differential effects of the nonpeptide neurotensin antagonist , SR_48692 , on the pharmacological effects of neurotensin agonists .
7716073	0	SR_48692	63,71	neurotensin	39,50	SR 48692	neurotensin	MESH:C079087	4922	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	Differential effects of the nonpeptide neurotensin antagonist , SR_48692 , on the pharmacological effects of neurotensin agonists .
7722490	0	SR_48692	36,44	neurotensin	12,23	SR 48692	neurotensin	MESH:C079087	299757(Tax:10116)	Chemical	Gene	receptor|nmod|START_ENTITY receptor|compound|END_ENTITY	Blockade of neurotensin receptor by SR_48692 potentiates the facilitatory effect of haloperidol on the evoked in vivo dopamine release in the rat nucleus accumbens .
7862953	0	SR_48692	11,19	neurotensin	45,56	SR 48692	neurotensin	MESH:C079087	299757(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|antagonist antagonist|compound|END_ENTITY	Effects of SR_48692 , a selective non-peptide neurotensin receptor antagonist , on two dopamine-dependent behavioural responses in mice and rats .
7865101	0	SR_48692	69,77	neurotensin	46,57	SR 48692	neurotensin	MESH:C079087	299757(Tax:10116)	Chemical	Gene	delays|compound|START_ENTITY development|nsubj|delays antagonist|xcomp|development antagonist|nsubj|END_ENTITY	Preexposure to , but not cotreatment with , the neurotensin antagonist SR_48692 delays the development of cocaine sensitization .
8058127	0	SR_48692	0,8	neurotensin	24,35	SR 48692	neurotensin	MESH:C079087	299757(Tax:10116)	Chemical	Gene	affects|advmod|START_ENTITY affects|nsubj|antagonist antagonist|compound|END_ENTITY	SR_48692 , a non-peptide neurotensin receptor antagonist differentially affects neurotensin-induced behaviour and changes in dopaminergic transmission .
8075852	0	SR_48692	39,47	neurotensin	15,26	SR 48692	neurotensin	MESH:C079087	299757(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	The nonpeptide neurotensin antagonist , SR_48692 , used as a tool to reveal putative neurotensin receptor subtypes .
8075852	0	SR_48692	39,47	neurotensin	83,94	SR 48692	neurotensin	MESH:C079087	299757(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY used|nsubj|antagonist used|xcomp|reveal reveal|dobj|subtypes subtypes|compound|END_ENTITY	The nonpeptide neurotensin antagonist , SR_48692 , used as a tool to reveal putative neurotensin receptor subtypes .
8309346	0	SR_48692	0,8	neurotensin	103,114	SR 48692	neurotensin	MESH:C079087	100727527	Chemical	Gene	blocks|nsubj|START_ENTITY blocks|dobj|effects effects|acl|elicited elicited|nmod|END_ENTITY	SR_48692 , a non-peptide neurotensin receptor antagonist , blocks the cardiovascular effects elicited by neurotensin in guinea_pigs .
8309346	0	SR_48692	0,8	neurotensin	24,35	SR 48692	neurotensin	MESH:C079087	100727527	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	SR_48692 , a non-peptide neurotensin receptor antagonist , blocks the cardiovascular effects elicited by neurotensin in guinea_pigs .
8581347	0	SR_48692	36,44	neurotensin	55,66	SR 48692	neurotensin	MESH:C079087	4922	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Pharmacological characterization of SR_48692 sensitive neurotensin receptor in human pancreatic_cancer cells , MIA PaCa-2 .
8821538	0	SR_48692	14,22	neurotensin	50,61	SR 48692	neurotensin	MESH:C079087	299757(Tax:10116)	Chemical	Gene	Antagonism|nmod|START_ENTITY Antagonism|xcomp|END_ENTITY	Antagonism by SR_48692 of mechanical responses to neurotensin in rat intestine .
8901630	0	SR_48692	26,34	neurotensin	2,13	SR 48692	neurotensin	MESH:C079087	299757(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	A neurotensin antagonist , SR_48692 , inhibits colonic responses to immobilization stress in rats .
9080465	0	SR_48692	11,19	neurotensin	173,184	SR 48692	neurotensin	MESH:C079087	67405(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|dep|activity activity|nmod|receptor receptor|compound|END_ENTITY	Effects of SR_48692 on neurotensin-induced calcium-activated chloride currents in the Xenopus oocyte expression system : agonist-like activity on the levocabastine-sensitive neurotensin receptor and absence of antagonist effect on the levocabastine insensitive neurotensin receptor .
9080465	0	SR_48692	11,19	neurotensin	260,271	SR 48692	neurotensin	MESH:C079087	67405(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|dep|activity activity|nmod|receptor receptor|nmod|effect effect|nmod|receptor receptor|compound|END_ENTITY	Effects of SR_48692 on neurotensin-induced calcium-activated chloride currents in the Xenopus oocyte expression system : agonist-like activity on the levocabastine-sensitive neurotensin receptor and absence of antagonist effect on the levocabastine insensitive neurotensin receptor .
9080465	1	SR_48692	305,313	neurotensin	361,372	SR 48692	neurotensin	MESH:C079087	67405(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|oocytes oocytes|amod|Cl Cl|dep|induced induced|nmod|END_ENTITY	The effect of the drug SR_48692 on the Ca -LRB- 2 + -RRB- - activated Cl - current induced by neurotensin on Xenopus oocytes injected with cRNAs encoding rodent high and low_affinity_neurotensin_receptors , was examined .
9105707	0	SR_48692	112,120	neurotensin	50,61	SR 48692	neurotensin	MESH:C079087	299757(Tax:10116)	Chemical	Gene	action|nmod|START_ENTITY mechanism|nmod|action modulation|nmod|mechanism modulation|nmod|production production|nmod|END_ENTITY	Negative modulation of nitric_oxide production by neurotensin as a putative mechanism of the diuretic action of SR_48692 in rats .
9262357	0	SR_48692	88,96	neurotensin	111,122	SR 48692	neurotensin	MESH:C079087	299757(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Dose-dependent pain-facilitatory and - inhibitory actions of neurotensin are revealed by SR_48692 , a nonpeptide neurotensin antagonist : influence on the antinociceptive effect of morphine .
9262357	0	SR_48692	88,96	neurotensin	60,71	SR 48692	neurotensin	MESH:C079087	299757(Tax:10116)	Chemical	Gene	revealed|nmod|START_ENTITY revealed|nsubjpass|pain-facilitatory pain-facilitatory|nmod|END_ENTITY	Dose-dependent pain-facilitatory and - inhibitory actions of neurotensin are revealed by SR_48692 , a nonpeptide neurotensin antagonist : influence on the antinociceptive effect of morphine .
9632698	1	SR_48692	116,124	neurotensin	139,150	SR 48692	neurotensin	MESH:C079087	299757(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Identification of residues that are critical for binding SR_48692 , a nonpeptide neurotensin antagonist .
7908971	0	SR_48968	0,8	NK-2-receptor	41,54	SR 48968	NK-2-receptor	MESH:C073839	100720631	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	SR_48968 , a novel non-peptide tachykinin NK-2-receptor antagonist , selectively inhibits the non-cholinergically mediated neurogenic contraction of guinea-pig isolated bronchial muscle .
8395297	0	SR_48968	65,73	NK2_receptor	40,52	SR 48968	NK2 receptor	MESH:C073839	100720631	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Postjunctional inhibitory effect of the NK2_receptor antagonist , SR_48968 , on sensory NANC bronchoconstriction in the guinea-pig .
8129742	0	SR_49059	65,73	V1a	37,40	SR 49059	V1a	MESH:C082134	54140(Tax:10090)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Effect of a new , potent , non-peptide V1a vasopressin antagonist , SR_49059 , on the binding and the mitogenic activity of vasopressin on Swiss_3T3 cells .
8392086	0	SR_49059	46,54	V1a	122,125	SR 49059	V1a	MESH:C082134	25107(Tax:10116)	Chemical	Gene	properties|nmod|START_ENTITY properties|appos|antagonist antagonist|nmod|receptors receptors|compound|END_ENTITY	Biochemical and pharmacological properties of SR_49059 , a new , potent , nonpeptide antagonist of rat and human vasopressin V1a receptors .
11035135	0	SR_49059	10,18	V1a_vasopressin_receptor	22,46	SR 49059	V1a vasopressin receptor	MESH:C082134	552	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|antagonist antagonist|amod|END_ENTITY	Effect of SR_49059 , a V1a_vasopressin_receptor antagonist , in Raynaud 's _ phenomenon .
9141585	0	SR_49059	11,19	V1a_vasopressin_receptor	38,62	SR 49059	V1a vasopressin receptor	MESH:C082134	552	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Effects of SR_49059 , an orally active V1a_vasopressin_receptor antagonist , on vasopressin-induced uterine contractions .
10026840	0	SR_49059	147,155	vasopressin	110,121	SR 49059	vasopressin	MESH:C082134	551	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	Evidence for an involvement of vasopressin in mechanism of primary dysmenorrhea and effect of the non-peptide vasopressin V1a receptor antagonist , SR_49059 , on the uterus of non-pregnant women .
10026840	0	SR_49059	147,155	vasopressin	31,42	SR 49059	vasopressin	MESH:C082134	551	Chemical	Gene	antagonist|appos|START_ENTITY Evidence|nmod|antagonist Evidence|nmod|END_ENTITY	Evidence for an involvement of vasopressin in mechanism of primary dysmenorrhea and effect of the non-peptide vasopressin V1a receptor antagonist , SR_49059 , on the uterus of non-pregnant women .
8549062	0	SR_49059	28,36	vasopressin	67,78	SR 49059	vasopressin	MESH:C082134	551	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Potent inhibitory effect of SR_49059 , an orally active non-peptide vasopressin VIa receptor antagonist , on human arterial coronary bypass graft .
9492709	0	SR_49059	52,60	vasopressin	107,118	SR 49059	vasopressin	MESH:C082134	551	Chemical	Gene	antagonist|appos|START_ENTITY Effects|nmod|antagonist Effects|nmod|substances substances|compound|END_ENTITY	Effects of the vasopressin V1a receptor antagonist , SR_49059 , on the response of human uterine arteries to vasopressin and other vasoactive substances .
9492709	0	SR_49059	52,60	vasopressin	15,26	SR 49059	vasopressin	MESH:C082134	551	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Effects of the vasopressin V1a receptor antagonist , SR_49059 , on the response of human uterine arteries to vasopressin and other vasoactive substances .
3040438	0	SR_95103	69,77	GABA-A	37,43	SR 95103	GABA-A	MESH:C044796	14405(Tax:10090)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Behavioural evidence for a selective GABA-A antagonistic activity of SR_95103 and SR_42641 after intrastriatal injection in mice .
3100771	5	SR_95191	546,554	MAO-A	577,582	SR 95191	MAO-A	MESH:C051273	4128	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|dobj|END_ENTITY	In vitro , SR_95191 selectively inhibited MAO-A and was less potent than cimoxatone , clorgyline and harmaline , but was more potent than moclobemide .
7952273	0	SR_95531	61,69	MAO-A	98,103	SR 95531	MAO-A	MESH:C049853	29253(Tax:10116)	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Radioautographic evidence that the GABAA receptor antagonist SR_95531 is a substrate inhibitor of MAO-A in the rat and human locus coeruleus .
21378177	3	SSO	612,615	CD36	570,574	SSO	CD36	null	12491(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	RESEARCH DESIGN AND METHODS : In vitro , the effect of CD36 inhibition and deletion in lipid-induced macrophage inflammation was assessed using the putative CD36 inhibitor , sulfosuccinimidyl_oleate -LRB- SSO -RRB- , and bone marrow-derived macrophages from mice with -LRB- CD36KO -RRB- or without -LRB- wild-type -RRB- global deletion of CD36 .
12438543	0	SSR182289A	0,10	thrombin	35,43	SSR182289A	thrombin	MESH:C469682	2147	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	SSR182289A , a novel , orally active thrombin inhibitor : in vitro profile and ex vivo anticoagulant activity .
12538808	0	SSR182289A	29,39	thrombin	62,70	SSR182289A	thrombin	MESH:C469682	29251(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Antithrombotic properties of SSR182289A , a new , orally active thrombin inhibitor .
20613495	0	SSR504734	0,9	glycine_transporter-1	13,34	SSR504734	glycine transporter-1	MESH:C507205	116509(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	SSR504734 , a glycine_transporter-1 inhibitor , attenuates acquisition and expression of contextual conditioned fear in rats .
11233992	0	SST	65,68	VIP	42,45	SST	VIP	null	7432	Chemical	Gene	peptide|appos|START_ENTITY peptide|appos|END_ENTITY	Effects of vasoactive intestinal peptide -LRB- VIP -RRB- and somatostatin -LRB- SST -RRB- on lipoprotein receptor expression by A431 tumor cells .
24757144	0	STA-21	0,6	STAT-3	20,26	STA-21	STAT-3	MESH:C500947	20848(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	STA-21 , a promising STAT-3 inhibitor that reciprocally regulates Th17 and Treg cells , inhibits osteoclastogenesis in mice and humans and alleviates autoimmune_inflammation in an experimental model of rheumatoid_arthritis .
24338788	0	STA-21	0,6	STAT3	20,25	STA-21	STAT3	MESH:C500947	20848(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	STA-21 , a promising STAT3 inhibitor that reciprocally regulates Th17 and Treg , inhibits osteoclastogenesis and alleviates autoimmune_inflammation .
20811392	0	STA-21	96,102	Stat3	0,5	STA-21	Stat3	MESH:C500947	6774	Chemical	Gene	study|nmod|START_ENTITY END_ENTITY|dep|study	Stat3 as a therapeutic target for the treatment of psoriasis : a clinical feasibility study with STA-21 , a Stat3 inhibitor .
20811392	0	STA-21	96,102	Stat3	106,111	STA-21	Stat3	MESH:C500947	6774	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Stat3 as a therapeutic target for the treatment of psoriasis : a clinical feasibility study with STA-21 , a Stat3 inhibitor .
22806877	0	STA-9090	12,20	HSP90	41,46	STA-9090	HSP90	MESH:C533237	104434(Tax:10090)	Chemical	Gene	Ganetespib|appos|START_ENTITY Ganetespib|appos|inhibitor inhibitor|compound|END_ENTITY	Ganetespib -LRB- STA-9090 -RRB- , a nongeldanamycin HSP90 inhibitor , has potent antitumor activity in in vitro and in vivo models of non-small_cell_lung_cancer .
21154128	0	STA-9090	0,8	Hsp90	27,32	STA-9090	Hsp90	MESH:C533237	3320	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	STA-9090 , a small-molecule Hsp90 inhibitor for the potential treatment of cancer .
21533169	0	STA-9090	61,69	Hsp90	33,38	STA-9090	Hsp90	MESH:C533237	111058(Tax:10090)	Chemical	Gene	intervention|appos|START_ENTITY intervention|nmod|ganetespib ganetespib|amod|END_ENTITY	Multifaceted intervention by the Hsp90 inhibitor ganetespib -LRB- STA-9090 -RRB- in cancer cells with activated JAK/STAT signaling .
26652486	0	STEROIDS	98,106	PTEN	0,4	STEROIDS	PTEN	MESH:D013256	5728	Chemical	Gene	START_ENTITY|nsubj|INDUCED INDUCED|compound|END_ENTITY	PTEN ELEVATION , AUTOPHAGY AND METABOLIC REPROGRAMMING MAY BE INDUCED IN HUMAN CHONDROCYTES DURING STEROIDS OR NUTRIENT DEPLETION AND OSTEOARTHRITIS .
12543778	5	STI-571	821,828	ABL	832,835	STI-571	ABL	MESH:C097613	25	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Addition of the Abl kinase inhibitor STI-571 to ABL SH2-transformed Rat-1 cells inhibited tyrosine phosphorylation of p145 ABL .
10910924	0	STI571	125,131	BCR-ABL	34,41	STI571	BCR-ABL	MESH:C097613	25	Chemical	Gene	sensitivity|nmod|START_ENTITY lines|nmod|sensitivity lines|amod|END_ENTITY	Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor STI571 : diverse mechanisms of resistance .
11853795	0	STI571	107,113	BCR-ABL	0,7	STI571	BCR-ABL	MESH:C097613	25	Chemical	Gene	resistance|nmod|START_ENTITY relation|nmod|resistance mutations|nmod|relation mutations|amod|END_ENTITY	BCR-ABL gene mutations in relation to clinical resistance of Philadelphia-chromosome-positive_leukaemia to STI571 : a prospective study .
11861307	0	STI571	78,84	BCR-ABL	98,105	STI571	BCR-ABL	MESH:C097613	25	Chemical	Gene	resistant|nmod|START_ENTITY acute_lymphoblastic_leukemia|amod|resistant has|nsubj|acute_lymphoblastic_leukemia has|dobj|mutation mutation|amod|END_ENTITY	Ph -LRB- + -RRB- acute_lymphoblastic_leukemia resistant to the tyrosine kinase inhibitor STI571 has a unique BCR-ABL gene mutation .
11872078	0	STI571	95,101	BCR-ABL	12,19	STI571	BCR-ABL	MESH:C097613	25	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|Kinetics Kinetics|nmod|levels levels|amod|END_ENTITY	Kinetics of BCR-ABL fusion transcript levels in chronic_myeloid_leukemia patients treated with STI571 measured by quantitative real-time polymerase chain reaction .
11905636	0	STI571	0,6	BCR-ABL	28,35	STI571	BCR-ABL	MESH:C097613	25	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|kinase kinase|amod|END_ENTITY	STI571 : an inhibitor of the BCR-ABL tyrosine kinase for the treatment of chronic_myelogenous_leukaemia .
11986783	0	STI571	55,61	BCR-ABL	65,72	STI571	BCR-ABL	MESH:C097613	25	Chemical	Gene	START_ENTITY|nmod|cells cells|amod|END_ENTITY	The in vitro activity of the tyrosine kinase inhibitor STI571 in BCR-ABL positive chronic_myeloid_leukaemia cells : synergistic interactions with anti-leukaemic agents .
12204532	0	STI571	113,119	BCR-ABL	9,16	STI571	BCR-ABL	MESH:C097613	25	Chemical	Gene	imatinib|appos|START_ENTITY confer|nmod|imatinib kinase|ccomp|confer kinase|nsubj|END_ENTITY	Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib -LRB- STI571 -RRB- in chronic phase and blast_crisis_chronic_myeloid_leukemia .
12358910	0	STI571	118,124	BCR-ABL	36,43	STI571	BCR-ABL	MESH:C097613	25	Chemical	Gene	resistance|nmod|START_ENTITY Mutation|nmod|resistance Mutation|nmod|END_ENTITY	Mutation in the ATP-binding site of BCR-ABL in a patient with chronic_myeloid_leukaemia with increasing resistance to STI571 .
12509383	0	STI571	116,122	BCR-ABL	0,7	STI571	BCR-ABL	MESH:C097613	25	Chemical	Gene	selected|nmod|START_ENTITY selected|nsubj|independence independence|amod|END_ENTITY	BCR-ABL independence and LYN kinase overexpression in chronic_myelogenous_leukemia cells selected for resistance to STI571 .
12538464	0	STI571	100,106	BCR-ABL	53,60	STI571	BCR-ABL	MESH:C097613	25	Chemical	Gene	monitoring|appos|START_ENTITY monitoring|nmod|END_ENTITY	Quantitative polymerase chain reaction monitoring of BCR-ABL during therapy with imatinib_mesylate -LRB- STI571 ; gleevec -RRB- in chronic-phase chronic myelogenous_leukemia .
12663457	0	STI571	52,58	BCR-ABL	16,23	STI571	BCR-ABL	MESH:C097613	25	Chemical	Gene	treatment|compound|START_ENTITY prior|nmod|treatment Glu255Lys|advmod|prior Glu255Lys|nsubj|Presence Presence|nmod|mutation mutation|amod|END_ENTITY	Presence of the BCR-ABL mutation Glu255Lys prior to STI571 -LRB- imatinib -RRB- treatment in patients with Ph + acute_lymphoblastic_leukemia .
15539083	0	STI571	41,47	BCR-ABL	140,147	STI571	BCR-ABL	MESH:C097613	25	Chemical	Gene	resistance|appos|START_ENTITY mechanism|nmod|resistance mechanism|dep|role role|nmod|TC-PTP TC-PTP|nmod|signals signals|acl|downstream downstream|nmod|protein protein|amod|END_ENTITY	A novel mechanism for imatinib_mesylate -LRB- STI571 -RRB- resistance in CML cell line KT-1 : role of TC-PTP in modulating signals downstream from the BCR-ABL fusion protein .
12476305	0	STI571	70,76	Bcr-Abl	29,36	STI571	Bcr-Abl	MESH:C097613	25	Chemical	Gene	therapies|dep|START_ENTITY therapies|nmod|leukemias leukemias|amod|END_ENTITY	Novel targeted therapies for Bcr-Abl positive acute leukemias : beyond STI571 .
12499247	0	STI571	148,154	Bcr-Abl	16,23	STI571	Bcr-Abl	MESH:C097613	25	Chemical	Gene	Gleevec|dep|START_ENTITY imatinib_mesylate|appos|Gleevec isoforms|nmod|imatinib_mesylate isoforms|nsubj|Activity Activity|nmod|PD180970 PD180970|amod|END_ENTITY	Activity of the Bcr-Abl kinase inhibitor PD180970 against clinically relevant Bcr-Abl isoforms that cause resistance to imatinib_mesylate -LRB- Gleevec , STI571 -RRB- .
12499247	0	STI571	148,154	Bcr-Abl	78,85	STI571	Bcr-Abl	MESH:C097613	25	Chemical	Gene	Gleevec|dep|START_ENTITY imatinib_mesylate|appos|Gleevec isoforms|nmod|imatinib_mesylate isoforms|nsubj|Activity Activity|nmod|PD180970 PD180970|nmod|END_ENTITY	Activity of the Bcr-Abl kinase inhibitor PD180970 against clinically relevant Bcr-Abl isoforms that cause resistance to imatinib_mesylate -LRB- Gleevec , STI571 -RRB- .
15109541	0	STI571	19,25	Bcr-Abl	61,68	STI571	Bcr-Abl	MESH:C097613	25	Chemical	Gene	Imatinib_mesylate|appos|START_ENTITY prevents|nsubj|Imatinib_mesylate prevents|dobj|phenotype phenotype|nmod|END_ENTITY	Imatinib_mesylate -LRB- STI571 -RRB- prevents the mutator phenotype of Bcr-Abl in hematopoietic cell lines .
15501042	0	STI571	20,26	Bcr-Abl	44,51	STI571	Bcr-Abl	MESH:C097613	25	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Urea derivatives of STI571 as inhibitors of Bcr-Abl and PDGFR kinases .
15625278	0	STI571	173,179	Bcr-Abl	131,138	STI571	Bcr-Abl	MESH:C097613	25	Chemical	Gene	imatinib_mesylate|compound|START_ENTITY induces|nmod|imatinib_mesylate induces|dobj|apoptosis apoptosis|nmod|Cells Cells|compound|END_ENTITY	Cotreatment with suberanoylanilide_hydroxamic_acid and 17-allylamino_17-demethoxygeldanamycin synergistically induces apoptosis in Bcr-Abl + Cells sensitive and resistant to STI571 -LRB- imatinib_mesylate -RRB- in association with down-regulation of Bcr-Abl , abrogation of signal transducer and activator of transcription 5 activity , and Bax conformational change .
15625278	0	STI571	173,179	Bcr-Abl	239,246	STI571	Bcr-Abl	MESH:C097613	25	Chemical	Gene	imatinib_mesylate|compound|START_ENTITY imatinib_mesylate|nmod|association association|nmod|down-regulation down-regulation|nmod|END_ENTITY	Cotreatment with suberanoylanilide_hydroxamic_acid and 17-allylamino_17-demethoxygeldanamycin synergistically induces apoptosis in Bcr-Abl + Cells sensitive and resistant to STI571 -LRB- imatinib_mesylate -RRB- in association with down-regulation of Bcr-Abl , abrogation of signal transducer and activator of transcription 5 activity , and Bax conformational change .
11439348	0	STI571	26,32	Hepatocyte_Growth_Factor	81,105	STI571	Hepatocyte Growth Factor	MESH:C097613	3082	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Tyrosine_kinase inhibitor STI571 enhances thyroid_cancer cell motile response to Hepatocyte_Growth_Factor .
18088462	0	STI571	1,7	Mcl-1	90,95	STI571	Mcl-1	MESH:C097613	4170	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|down-regulation down-regulation|nmod|END_ENTITY	-LSB- STI571 induces apoptosis of K562 cells through down-regulation of anti-apoptotic protein Mcl-1 and Bcl-xl expression -RSB- .
12963124	0	STI571	63,69	P-glycoprotein	77,91	STI571	P-glycoprotein	MESH:C097613	5243	Chemical	Gene	START_ENTITY|nmod|line line|amod|END_ENTITY	Anti-proliferative effect of the abl tyrosine kinase inhibitor STI571 on the P-glycoprotein positive K562/ADM cell line .
12750174	0	STI571	97,103	bcr-abl	14,21	STI571	bcr-abl	MESH:C097613	25	Chemical	Gene	mesylate|appos|START_ENTITY Inhibition|nmod|mesylate Inhibition|nmod|expression expression|amod|END_ENTITY	Inhibition of bcr-abl gene expression by small interfering RNA sensitizes for imatinib mesylate -LRB- STI571 -RRB- .
15555283	0	STI571	34,40	bcr-abl	133,140	STI571	bcr-abl	MESH:C097613	25	Chemical	Gene	effect|nmod|START_ENTITY inhibitory|dobj|effect inhibitory|nmod|arsenic_trioxide arsenic_trioxide|nmod|line line|acl|expressing expressing|dobj|-RSB- -RSB-|amod|END_ENTITY	-LSB- Synergistic inhibitory effect of STI571 in combination with arsenic_trioxide on a multidrug-resistant_leukemia cell line expressing bcr-abl -RSB- .
12844407	0	STI571	20,26	c-kit	44,49	STI571	c-kit	MESH:C097613	3815	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- In vitro effect of STI571 on expression of c-kit in bone marrow cells from patients with acute_non-lymphocytic_leukemia -RSB- .
16140951	0	STI571	71,77	platelet-derived_growth_factor_receptor-beta	10,54	STI571	platelet-derived growth factor receptor-beta	MESH:C097613	5159	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|inhibition inhibition|amod|END_ENTITY	Effect of platelet-derived_growth_factor_receptor-beta inhibition with STI571 on radioimmunotherapy .
16521182	0	STI571	0,6	vascular_endothelial_growth_factor	45,79	STI571	vascular endothelial growth factor	MESH:C097613	7422	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|nmod|END_ENTITY	STI571 -LRB- Glivec -RRB- suppresses the expression of vascular_endothelial_growth_factor in the gastrointestinal_stromal_tumor cell line , GIST-T1 .
23349762	0	STK295900	0,9	topoisomerase_1	31,46	STK295900	topoisomerase 1	null	7150	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	STK295900 , a dual inhibitor of topoisomerase_1 and 2 , induces G -LRB- 2 -RRB- arrest in the absence of DNA damage .
17000691	0	STX213	20,26	steroid_sulfatase	48,65	STX213	steroid sulfatase	MESH:C515227	20905(Tax:10090)	Chemical	Gene	efficacy|nmod|START_ENTITY END_ENTITY|nmod|efficacy	In vivo efficacy of STX213 , a second-generation steroid_sulfatase inhibitor , for hormone-dependent breast_cancer therapy .
17000691	2	STX64	383,388	STS	367,370	STX64	STS	null	412	Chemical	Gene	inhibitors|appos|START_ENTITY inhibitors|compound|END_ENTITY	We compare the in vivo efficacy of two potent STS inhibitors , STX64 and STX213 , in a xenograft breast_cancer model .
20926985	0	STY39	0,5	alpha-melanocyte-stimulating_hormone	15,51	STY39	alpha-melanocyte-stimulating hormone	null	18976(Tax:10090)	Chemical	Gene	START_ENTITY|appos|analogue analogue|amod|END_ENTITY	STY39 , a novel alpha-melanocyte-stimulating_hormone analogue , attenuates bleomycin-induced pulmonary_inflammation and fibrosis in mice .
16867213	0	ST_1535	0,7	A2A	24,27	ST 1535	A2A	MESH:C506291	28882	Chemical	Gene	START_ENTITY|dep|antagonist antagonist|compound|END_ENTITY	ST_1535 : a preferential A2A adenosine receptor antagonist .
26127123	0	SU-C-303-01	0,11	Activation-Induced_Cytidine_Deaminase	13,50	SU-C-303-01	Activation-Induced Cytidine Deaminase	null	11628(Tax:10090)	Chemical	Gene	START_ENTITY|dep|Resistance Resistance|compound|END_ENTITY	SU-C-303-01 : Activation-Induced_Cytidine_Deaminase Confers Cancer Resistance to Radiation Therapy .
11309325	0	SU101	40,45	platelet-derived_growth_factor_receptor	49,88	SU101	platelet-derived growth factor receptor	MESH:C045463	5159	Chemical	Gene	study|nmod|START_ENTITY study|appos|inhibitor inhibitor|amod|END_ENTITY	A multi-institutional phase ii study of SU101 , a platelet-derived_growth_factor_receptor inhibitor , for patients with hormone-refractory_prostate_cancer .
12531805	0	SU11248	0,7	FLT3	19,23	SU11248	FLT3	MESH:C473478	2322	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|compound|END_ENTITY	SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo .
16910860	0	SU11248	65,72	vascular_endothelial_growth_factor_receptor_2	8,53	SU11248	vascular endothelial growth factor receptor 2	MESH:C473478	3791	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	A novel vascular_endothelial_growth_factor_receptor_2 inhibitor , SU11248 , suppresses choroidal_neovascularization in vivo .
21575221	0	SU11274	96,103	c-Met	29,34	SU11274	c-Met	MESH:C478479	4233	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of phosphorylated c-Met in rhabdomyosarcoma cell lines by a small molecule inhibitor SU11274 .
22200847	5	SU5402	911,917	FGF-2	971,976	SU5402	FGF-2	MESH:C105686	2247	Chemical	Gene	treated|nmod|START_ENTITY treated|nmod|END_ENTITY	When PDL cells were treated with SU5402 -LRB- an inhibitor of FGF receptor 1 -RRB- in combination with FGF-2 , the FGF-2-reduced expression of SDF-1a was inhibited .
22309941	8	SU5402	1292,1298	bFGF	1277,1281	SU5402	bFGF	MESH:C105686	396413(Tax:9031)	Chemical	Gene	action|nmod|START_ENTITY action|compound|END_ENTITY	In contrast , blockade of bFGF action by SU5402 -LRB- an FGFR1 antagonist -RRB- or inhibition of protein kinase C signaling showed inhibited effect of bFGF on mitosis .
22970246	0	SU5416	0,6	AHR	52,55	SU5416	AHR	MESH:C116890	196	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	SU5416 , a VEGF receptor inhibitor and ligand of the AHR , represents a new alternative for immunomodulation .
11733657	0	SU5416	33,39	Flk-1	0,5	SU5416	Flk-1	MESH:C116890	25589(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Flk-1 specific kinase inhibitor -LRB- SU5416 -RRB- inhibited the growth of GS-9L_glioma in rat brain and prolonged the survival .
15217937	0	SU5416	54,60	Flk-1	22,27	SU5416	Flk-1	MESH:C116890	3791	Chemical	Gene	tyrosine|dobj|START_ENTITY tyrosine|nsubj|study study|nmod|END_ENTITY	Phase II study of the Flk-1 tyrosine kinase inhibitor SU5416 in advanced melanoma .
9892193	0	SU5416	0,6	Flk-1	95,100	SU5416	Flk-1	MESH:C116890	3791	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|appos|KDR KDR|compound|END_ENTITY	SU5416 is a potent and selective inhibitor of the vascular_endothelial_growth_factor receptor -LRB- Flk-1 / KDR -RRB- that inhibits tyrosine kinase catalysis , tumor vascularization , and growth of multiple tumor types .
9892193	0	SU5416	0,6	KDR	101,104	SU5416	KDR	MESH:C116890	3791	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|appos|END_ENTITY	SU5416 is a potent and selective inhibitor of the vascular_endothelial_growth_factor receptor -LRB- Flk-1 / KDR -RRB- that inhibits tyrosine kinase catalysis , tumor vascularization , and growth of multiple tumor types .
15474452	0	SU5416	0,6	VEGF	17,21	SU5416	VEGF	MESH:C116890	7422	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|dobj|expression expression|amod|END_ENTITY	SU5416 inhibited VEGF and HIF-1alpha expression through the PI3K/AKT/p70S6K1 signaling pathway .
19065567	0	SU5416	17,23	VEGFR	104,109	SU5416	VEGFR	MESH:C116890	3791	Chemical	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Phase I study of SU5416 , a small molecule inhibitor of the vascular_endothelial_growth_factor_receptor -LRB- VEGFR -RRB- in refractory pediatric central_nervous_system_tumors .
11156244	0	SU5416	27,33	vascular_endothelial_growth_factor	62,96	SU5416	vascular endothelial growth factor	MESH:C116890	7422	Chemical	Gene	has|nsubj|START_ENTITY has|dobj|effects effects|nmod|phosphorylation phosphorylation|compound|END_ENTITY	The angiogenesis inhibitor SU5416 has long-lasting effects on vascular_endothelial_growth_factor receptor phosphorylation and function .
12673719	0	SU5416	18,24	vascular_endothelial_growth_factor	44,78	SU5416	vascular endothelial growth factor	MESH:C116890	7422	Chemical	Gene	study|nmod|START_ENTITY study|dep|small-molecule small-molecule|appos|inhibitor inhibitor|amod|END_ENTITY	Phase II study of SU5416 -- a small-molecule , vascular_endothelial_growth_factor tyrosine-kinase receptor inhibitor -- in patients with refractory myeloproliferative diseases .
14734456	0	SU5416	18,24	vascular_endothelial_growth_factor	43,77	SU5416	vascular endothelial growth factor	MESH:C116890	7422	Chemical	Gene	study|nmod|START_ENTITY Phase|dobj|study tyrosine|advcl|Phase tyrosine|nsubj|END_ENTITY	Phase II study of SU5416 , a small molecule vascular_endothelial_growth_factor tyrosine kinase receptor inhibitor , in patients with refractory multiple_myeloma .
21691137	0	SU5416	22,28	vascular_endothelial_growth_factor	42,76	SU5416	vascular endothelial growth factor	MESH:C116890	22339(Tax:10090)	Chemical	Gene	START_ENTITY|appos|receptor receptor|compound|END_ENTITY	Inhibitory effects of SU5416 , a selective vascular_endothelial_growth_factor receptor tyrosine kinase inhibitor , on experimental corneal_neovascularization .
9892193	0	SU5416	0,6	vascular_endothelial_growth_factor	50,84	SU5416	vascular endothelial growth factor	MESH:C116890	7422	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|receptor receptor|compound|END_ENTITY	SU5416 is a potent and selective inhibitor of the vascular_endothelial_growth_factor receptor -LRB- Flk-1 / KDR -RRB- that inhibits tyrosine kinase catalysis , tumor vascularization , and growth of multiple tumor types .
19065567	0	SU5416	17,23	vascular_endothelial_growth_factor_receptor	59,102	SU5416	vascular endothelial growth factor receptor	MESH:C116890	3791	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Phase I study of SU5416 , a small molecule inhibitor of the vascular_endothelial_growth_factor_receptor -LRB- VEGFR -RRB- in refractory pediatric central_nervous_system_tumors .
22244830	0	SU6656	53,59	Src	27,30	SU6656	Src	MESH:C416927	6714	Chemical	Gene	kinases|nmod|START_ENTITY kinases|compound|END_ENTITY	Simultaneous inhibition of Src and Aurora kinases by SU6656 induces therapeutic synergy in human synovial_sarcoma growth , invasion and angiogenesis in vivo .
24093774	0	SU6656	24,30	Src	46,49	SU6656	Src	MESH:C416927	6714	Chemical	Gene	mTORC1|nmod|START_ENTITY Inhibition|nmod|mTORC1 Inhibition|appos|inhibitor inhibitor|compound|END_ENTITY	Inhibition of mTORC1 by SU6656 , the selective Src kinase inhibitor , is not accompanied by activation of Akt/PKB signalling in melanoma cells .
11074000	0	SU6656	0,6	src	20,23	SU6656	src	MESH:C416927	6714	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	SU6656 , a selective src family kinase inhibitor , used to probe growth factor signaling .
11978732	0	SU6668	0,6	KDR	22,25	SU6668	KDR	MESH:C412603	16542(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	SU6668 inhibits Flk-1 / KDR and PDGFRbeta in vivo , resulting in rapid apoptosis of tumor vasculature and tumor regression in mice .
23984913	0	SU6668	0,6	MTDH	95,99	SU6668	MTDH	MESH:C412603	92140	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|expression expression|compound|END_ENTITY	SU6668 suppresses proliferation of triple_negative_breast_cancer cells through down-regulating MTDH expression .
12234612	0	SU9516	0,6	cyclin-dependent_kinase_2	10,35	SU9516	cyclin-dependent kinase 2	MESH:C433985	1017	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	SU9516 , a cyclin-dependent_kinase_2 inhibitor , promotes accumulation of high molecular weight E2F complexes in human colon_carcinoma cells .
16672643	0	SU9516	146,152	cyclin-dependent_kinase_2	33,58	SU9516	cyclin-dependent kinase 2	MESH:C433985	1017	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	The three-substituted indolinone cyclin-dependent_kinase_2 inhibitor 3 - -LSB- 1 - -LRB- 3H-imidazol-4-yl -RRB- - meth - -LRB- Z -RRB- - ylidene -RSB- -5 - methoxy-1 ,3 - dihydro-indol-2-one -LRB- SU9516 -RRB- kills human leukemia cells via down-regulation of Mcl-1 through a transcriptional mechanism .
12917021	0	SUCI02	1,7	HER-2	17,22	SUCI02	HER-2	MESH:C480138	2064	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	-LSB- SUCI02 inhibits HER-2 / neu receptor_tyrosine_kinase phosphorylation and growth of HER-2 / neu-overexpressing breast_cancer cells -RSB- .
12917021	0	SUCI02	1,7	HER-2	82,87	SUCI02	HER-2	MESH:C480138	2064	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|parataxis|neu neu|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	-LSB- SUCI02 inhibits HER-2 / neu receptor_tyrosine_kinase phosphorylation and growth of HER-2 / neu-overexpressing breast_cancer cells -RSB- .
12917021	0	SUCI02	1,7	neu	23,26	SUCI02	neu	MESH:C480138	2064	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|parataxis|END_ENTITY	-LSB- SUCI02 inhibits HER-2 / neu receptor_tyrosine_kinase phosphorylation and growth of HER-2 / neu-overexpressing breast_cancer cells -RSB- .
8057528	0	SUN_8399	11,19	5-HT1A	44,50	SUN 8399	5-HT1A	MESH:C088257	15550(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|agonist agonist|amod|END_ENTITY	Effects of SUN_8399 , a potent and selective 5-HT1A agonist , on conflict behavior and ambulatory activity in mice : comparison with those of buspirone , tandospirone and diazepam .
11012558	0	S_17092	47,54	prolyl_endopeptidase	76,96	S 17092	prolyl endopeptidase	MESH:C118986	5550	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Pharmacodynamic and pharmacokinetic profile of S_17092 , a new orally active prolyl_endopeptidase inhibitor , in elderly healthy volunteers .
17700042	0	S_17092	24,31	prolyl_endopeptidase	35,55	S 17092	prolyl endopeptidase	MESH:C118986	5550	Chemical	Gene	profile|nmod|START_ENTITY profile|appos|inhibitor inhibitor|amod|END_ENTITY	Psychotropic profile of S_17092 , a prolyl_endopeptidase inhibitor , using quantitative EEG in young healthy volunteers .
15992071	0	S_18326	0,7	thrombin	11,19	S 18326	thrombin	MESH:C109574	2147	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	S_18326 : a thrombin inhibitor that shows potential for oral treatment of thromboembolic_disorders .
10350017	0	S_20499	77,84	5-HT1A	99,105	S 20499	5-HT1A	MESH:C075319	3350	Chemical	Gene	START_ENTITY|appos|agonist agonist|nummod|END_ENTITY	Production and characterization of 22 monoclonal antibodies directed against S_20499 , a new potent 5-HT1A chiral agonist : influence of the hapten structure on specificity and stereorecognition .
24668740	0	Safranal	0,8	protein_tyrosine_phosphatase_1B	18,49	Safranal	protein tyrosine phosphatase 1B	MESH:C087963	19246(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Safranal , a novel protein_tyrosine_phosphatase_1B inhibitor , activates insulin signaling in C2C12 myotubes and improves glucose tolerance in diabetic KK-Ay mice .
24565837	0	Saikosaponin_C	0,14	caspase-3	76,85	Saikosaponin C	caspase-3	MESH:C025759	836	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|suppressing suppressing|dobj|activation activation|amod|END_ENTITY	Saikosaponin_C inhibits lipopolysaccharide-induced apoptosis by suppressing caspase-3 activation and subsequent degradation of focal_adhesion_kinase in human umbilical vein endothelial cells .
23554830	0	Saikosaponin_a	0,14	CA1	84,87	Saikosaponin a	CA1	MESH:C025759	310218(Tax:10116)	Chemical	Gene	Current|compound|START_ENTITY Current|nmod|Neurons Neurons|compound|END_ENTITY	Saikosaponin_a Enhances Transient Inactivating Potassium Current in Rat Hippocampal CA1 Neurons .
18522800	0	Sakuranetin	0,11	PPARgamma2	80,90	Sakuranetin	PPARgamma2	MESH:C099724	19016(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|expression expression|nmod|END_ENTITY	Sakuranetin induces adipogenesis of 3T3-L1 cells through enhanced expression of PPARgamma2 .
17161617	0	Salbutamol	0,10	CXCL8	51,56	Salbutamol	CXCL8	MESH:D000420	3576	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|nmod|END_ENTITY	Salbutamol inhibits trypsin-mediated production of CXCL8 by keratinocytes .
26849227	0	Salbutamol	50,60	MKP-1	93,98	Salbutamol	MKP-1	MESH:D000420	19252(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Mediated|nsubjpass|Effects Mediated|nmod|END_ENTITY	Anti-Inflammatory Effects of b2-Receptor Agonists Salbutamol and Terbutaline Are Mediated by MKP-1 .
7559525	0	Salbutamol	0,10	PDE4	24,28	Salbutamol	PDE4	MESH:D000420	5141	Chemical	Gene	up-regulates|amod|START_ENTITY END_ENTITY|nsubj|up-regulates	Salbutamol up-regulates PDE4 activity and induces a heterologous desensitization of U937 cells to prostaglandin_E2 .
26076973	0	Salbutamol	0,10	RhoA	20,24	Salbutamol	RhoA	MESH:D000420	387	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|compound|END_ENTITY	Salbutamol inhibits RhoA activation in normal but not in desensitized bronchial smooth muscle cells .
17932121	0	Salbutamol	0,10	SMN	21,24	Salbutamol	SMN	MESH:D000420	6606	Chemical	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	Salbutamol increases SMN mRNA and protein levels in spinal_muscular_atrophy cells .
1335400	0	Salbutamol	0,10	beta_2-adrenoceptor	14,33	Salbutamol	beta 2-adrenoceptor	MESH:D000420	154	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Salbutamol , a beta_2-adrenoceptor agonist , increases skeletal muscle strength in young men .
19487934	0	Salbutamol	0,10	matrix_metalloproteinase-9	24,50	Salbutamol	matrix metalloproteinase-9	MESH:D000420	4318	Chemical	Gene	up-regulates|nsubj|START_ENTITY up-regulates|xcomp|END_ENTITY	Salbutamol up-regulates matrix_metalloproteinase-9 in the alveolar space in the acute respiratory_distress_syndrome .
21801305	0	Salermide	0,9	death_receptor_5	23,39	Salermide	death receptor 5	MESH:C539427	8795	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Salermide up-regulates death_receptor_5 expression through the ATF4-ATF3-CHOP axis and leads to apoptosis in human cancer cells .
25940306	0	Salicylate	0,10	AMPK	21,25	Salicylate	AMPK	CHEBI:30762	5563	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Salicylate activates AMPK and synergizes with metformin to reduce the survival of prostate and lung_cancer cells ex vivo through inhibition of de novo lipogenesis .
15106733	0	Salicylate	0,10	COX-2	21,26	Salicylate	COX-2	CHEBI:30762	5743	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Salicylate regulates COX-2 expression through ERK and subsequent NF-kappaB activation in osteoblasts .
15106733	0	Salicylate	0,10	ERK	46,49	Salicylate	ERK	CHEBI:30762	5594	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Salicylate regulates COX-2 expression through ERK and subsequent NF-kappaB activation in osteoblasts .
21782002	0	Salicylate	0,10	Hsp70	21,26	Salicylate	Hsp70	CHEBI:30762	3308	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	Salicylate modulates Hsp70 expression in the explanted organ of Corti .
24147110	6	Salicylate	929,939	IL-1b	1007,1012	Salicylate	IL-12	CHEBI:30762	64546(Tax:10116)	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|nmod|END_ENTITY	Salicylate administered concurrently with KRV + pIC inhibited the elevations in IL-1b , IL-6 , IFN-y and haptoglobin almost completely , and reduced IL-12 levels significantly .
14717919	0	Salicylate	0,10	tumor_necrosis_factor-alpha	61,88	Salicylate	tumor necrosis factor-alpha	CHEBI:30762	21926(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|nmod|inhibition inhibition|nmod|END_ENTITY	Salicylate reduces cisplatin nephrotoxicity by inhibition of tumor_necrosis_factor-alpha .
1847381	0	Salicylhydroxamic_acid	0,22	myeloperoxidase	32,47	Salicylhydroxamic acid	myeloperoxidase	MESH:C005703	4353	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Salicylhydroxamic_acid inhibits myeloperoxidase activity .
26606248	0	Salicylic_Acid	56,70	GAPDH	6,11	Salicylic Acid	GAPDH	MESH:D020156	2597	Chemical	Gene	Target|nmod|START_ENTITY Target|nsubj|END_ENTITY	Human GAPDH Is a Target of Aspirin 's Primary Metabolite Salicylic_Acid and Its Derivatives .
26101955	0	Salicylic_Acid	28,42	High_Mobility_Group_Box_1	51,76	Salicylic Acid	High Mobility Group Box 1	MESH:D020156	3146	Chemical	Gene	Targets|nsubj|START_ENTITY Targets|dobj|END_ENTITY	Aspirin 's Active Metabolite Salicylic_Acid Targets High_Mobility_Group_Box_1 to Modulate Inflammatory Responses .
23833938	0	Salicylic_acid	1,15	GK	52,54	Salicylic acid	GK	MESH:D020156	2645	Chemical	Gene	derivatives|compound|START_ENTITY END_ENTITY|nsubj|derivatives	-LSB- Salicylic_acid derivatives as simplified and novel GK small molecule activators -RSB- .
22785561	0	Salicylic_acid	0,14	NPR3	21,25	Salicylic acid	NPR3	MESH:D020156	4883	Chemical	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Salicylic_acid binds NPR3 and NPR4 to regulate NPR1-dependent defense responses .
15674440	0	Salicylic_acid	0,14	endothelin-1	22,34	Salicylic acid	endothelin-1	MESH:D020156	24323(Tax:10116)	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|END_ENTITY	Salicylic_acid alters endothelin-1 binding in intact adult rat ventricular myocytes .
23835496	0	Salidroside	0,11	mucin	33,38	Salidroside	mucin	MESH:C009172	100508689	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|production production|compound|END_ENTITY	Salidroside reduces cold-induced mucin production by inhibiting TRPM8 activation .
24905570	0	Salinomycin	0,11	LRP6	23,27	Salinomycin	LRP6	MESH:C010327	4040	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Salinomycin suppresses LRP6 expression and inhibits both Wnt/b-catenin and mTORC1 signaling in breast_and_prostate_cancer cells .
25522777	0	Salinomycin	0,11	MMP9	108,112	Salinomycin	MMP9	MESH:C010327	4318	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|expression expression|compound|END_ENTITY	Salinomycin inhibits hepatocellular_carcinoma cell invasion and migration through JNK/JunD pathway-mediated MMP9 expression .
23805285	0	Salinomycin	22,33	NAG-1	158,163	Salinomycin	NAG-1	MESH:C010327	9518	Chemical	Gene	Effects|nmod|START_ENTITY Effects|dep|Involvement Involvement|nmod|END_ENTITY	Inhibitory Effects of Salinomycin on Cell Survival , Colony Growth , Migration , and Invasion of Human Non-Small_Cell_Lung_Cancer A549 and LNM35 : Involvement of NAG-1 .
24740347	0	Salinomycin	0,11	TRAIL	49,54	Salinomycin	TRAIL	MESH:C010327	8743	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|effects effects|nmod|END_ENTITY	Salinomycin potentiates the cytotoxic effects of TRAIL on glioblastoma cell lines .
21573958	0	Salinomycin	0,11	p-glycoprotein	15,29	Salinomycin	p-glycoprotein	MESH:C010327	5243	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Salinomycin , a p-glycoprotein inhibitor , sensitizes radiation-treated cancer cells by increasing DNA damage and inducing G2_arrest .
25356157	0	Salmeterol	0,10	COPD	57,61	Salmeterol	COPD	MESH:C057823	260431	Chemical	Gene	improved|nsubj|START_ENTITY improved|dobj|END_ENTITY	Salmeterol combined with fluticasone_propionate improved COPD in patients during stable stage .
25356157	1	Salmeterol	147,157	COPD	273,277	Salmeterol	COPD	MESH:C057823	260431	Chemical	Gene	effect|nmod|START_ENTITY evaluate|dobj|effect evaluate|nmod|Fluticasone_propionate Fluticasone_propionate|nmod|patients patients|nmod|chronic_obstructive_pulmonary_disease chronic_obstructive_pulmonary_disease|appos|END_ENTITY	PURPOSE : To evaluate the clinical effect of inhaled Salmeterol with Fluticasone_propionate -LRB- 50:500 g -RRB- in patients with moderate to severe chronic_obstructive_pulmonary_disease -LRB- COPD -RRB- during the stable stage of the disease .
1686740	0	Salmeterol	0,10	beta_2-adrenoceptor	33,52	Salmeterol	beta 2-adrenoceptor	MESH:C057823	100722663	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Salmeterol , a novel , long-acting beta_2-adrenoceptor agonist : characterization of pharmacological activity in vitro and in vivo .
7902176	0	Salmeterol	0,10	beta_2-adrenoceptor	26,45	Salmeterol	beta 2-adrenoceptor	MESH:C057823	154	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Salmeterol , a long-acting beta_2-adrenoceptor agonist mediating cyclic_AMP accumulation in a neuronal cell line .
2904183	0	Salmeterol	0,10	beta_2_adrenoceptor	38,57	Salmeterol	beta 2 adrenoceptor	MESH:C057823	154	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Salmeterol , a new long acting inhaled beta_2_adrenoceptor agonist : comparison with salbutamol in adult asthmatic patients .
8796447	0	Salmeterol	0,10	interferon-gamma	20,36	Salmeterol	interferon-gamma	MESH:C057823	3458	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	Salmeterol inhibits interferon-gamma and interleukin-4 production by human peripheral blood mononuclear cells .
23948064	0	Salsalate	0,9	fetuin-A	87,95	Salsalate	fetuin-A	MESH:C014182	25373(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Salsalate and adiponectin ameliorate hepatic_steatosis by inhibition of the hepatokine fetuin-A .
26610526	0	Salternamide_A	0,14	HIF-1a	58,64	Salternamide A	HIF-1a	MESH:C000600890	3091	Chemical	Gene	Accumulation|compound|START_ENTITY Accumulation|nmod|END_ENTITY	Salternamide_A Suppresses Hypoxia-Induced Accumulation of HIF-1a and Induces Apoptosis in Human Colorectal_Cancer_Cells .
25206542	0	Salvianolate	0,12	heat_shock_protein	23,41	Salvianolate	heat shock protein	MESH:C561960	290549(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Salvianolate increases heat_shock_protein expression in a cerebral_ischemia-reperfusion injury model .
26415806	0	Salvianolic_Acid_B	0,18	Matrix_Metalloproteinase-9	34,60	Salvianolic Acid B	Matrix Metalloproteinase-9	MESH:C076944	4318	Chemical	Gene	Down-regulates|compound|START_ENTITY END_ENTITY|nsubj|Down-regulates	Salvianolic_Acid_B Down-regulates Matrix_Metalloproteinase-9 Activity and Expression in Tumor_Necrosis_Factor-a-induced Human Coronary Artery Endothelial Cells .
24853487	0	Salvianolic_acid_A	0,18	CCL-20	30,36	Salvianolic acid A	CCL-20	MESH:C066201	20297(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Salvianolic_acid_A suppresses CCL-20 expression in TNF-a-treated macrophages and ApoE-deficient mice .
23533637	0	Salvianolic_acid_A	0,18	matrix_metalloproteinase-9	28,54	Salvianolic acid A	matrix metalloproteinase-9	MESH:C066201	81687(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Salvianolic_acid_A , a novel matrix_metalloproteinase-9 inhibitor , prevents cardiac remodeling in spontaneously hypertensive rats .
24916705	0	Salvianolic_acid_A	0,18	matrix_metalloproteinase-9	22,48	Salvianolic acid A	matrix metalloproteinase-9	MESH:C066201	17395(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Salvianolic_acid_A , a matrix_metalloproteinase-9 inhibitor of Salvia miltiorrhiza , attenuates aortic aneurysm formation in apolipoprotein_E-deficient mice .
16713603	0	Salvianolic_acid_B	0,18	MMP-2	101,106	Salvianolic acid B	MMP-2	MESH:C076944	4313	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|tumor_necrosis_factor-alpha tumor_necrosis_factor-alpha|dep|species species|compound|END_ENTITY	Salvianolic_acid_B from Salvia miltiorrhiza inhibits tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- - induced MMP-2 upregulation in human aortic smooth muscle cells via suppression of NAD -LRB- P -RRB- H oxidase-derived reactive oxygen species .
16924668	0	Salvianolic_acid_B	0,18	MMP-2	30,35	Salvianolic acid B	MMP-2	MESH:C076944	17390(Tax:10090)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|amod|END_ENTITY	Salvianolic_acid_B attenuates MMP-2 and MMP-9 expression in vivo in apolipoprotein-E-deficient mouse aorta and in vitro in LPS-treated human aortic smooth muscle cells .
16052513	0	Salvianolic_acid_B	0,18	TNF-alpha	83,92	Salvianolic acid B	TNF-alpha	MESH:C076944	7124	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|nmod|END_ENTITY	Salvianolic_acid_B attenuates plasminogen_activator_inhibitor_type_1 production in TNF-alpha treated human umbilical vein endothelial cells .
11500927	0	Salvianolic_acid_B	0,18	VCAM-1	30,36	Salvianolic acid B	VCAM-1	MESH:C076944	7412	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|amod|END_ENTITY	Salvianolic_acid_B attenuates VCAM-1 and ICAM-1 expression in TNF-alpha-treated human aortic endothelial cells .
25869243	0	Salvianolic_acid_B	0,18	catechol-O-methyltransferase	43,71	Salvianolic acid B	catechol-O-methyltransferase	MESH:C076944	24267(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|amod|END_ENTITY	Salvianolic_acid_B as a substrate and weak catechol-O-methyltransferase inhibitor in rats .
16440326	0	Salvianolic_acid_B	0,18	cyclooxygenase-2	30,46	Salvianolic acid B	cyclooxygenase-2	MESH:C076944	5743	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|amod|END_ENTITY	Salvianolic_acid_B attenuates cyclooxygenase-2 expression in vitro in LPS-treated human aortic smooth muscle cells and in vivo in the apolipoprotein-E-deficient mouse aorta .
24934350	0	Salvianolic_acid_B	0,18	heme_oxygenase-1	96,112	Salvianolic acid B	heme oxygenase-1	MESH:C076944	3162	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|induction induction|nmod|END_ENTITY	Salvianolic_acid_B inhibits atherogenesis of vascular cells through induction of Nrf2-dependent heme_oxygenase-1 .
20735854	0	Salvianolic_acid_B	0,18	matrix_metalloproteinase-9	60,86	Salvianolic acid B	matrix metalloproteinase-9	MESH:C076944	81687(Tax:10116)	Chemical	Gene	functioned|nsubj|START_ENTITY functioned|advcl|prevented prevented|nsubj|inhibitor inhibitor|nmod|END_ENTITY	Salvianolic_acid_B functioned as a competitive inhibitor of matrix_metalloproteinase-9 and efficiently prevented cardiac_remodeling .
16052513	0	Salvianolic_acid_B	0,18	plasminogen_activator_inhibitor_type_1	30,68	Salvianolic acid B	plasminogen activator inhibitor type 1	MESH:C076944	5054	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|production production|amod|END_ENTITY	Salvianolic_acid_B attenuates plasminogen_activator_inhibitor_type_1 production in TNF-alpha treated human umbilical vein endothelial cells .
16713603	0	Salvianolic_acid_B	0,18	tumor_necrosis_factor-alpha	53,80	Salvianolic acid B	tumor necrosis factor-alpha	MESH:C076944	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Salvianolic_acid_B from Salvia miltiorrhiza inhibits tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- - induced MMP-2 upregulation in human aortic smooth muscle cells via suppression of NAD -LRB- P -RRB- H oxidase-derived reactive oxygen species .
14718611	0	Salvinorin_A	0,12	kappa-opioid_receptor	102,123	Salvinorin A	kappa-opioid receptor	MESH:C090499	4986	Chemical	Gene	START_ENTITY|appos|component component|nmod|divinorum divinorum|acl:relcl|agonist agonist|amod|END_ENTITY	Salvinorin_A , an active component of the hallucinogenic sage salvia divinorum is a highly efficacious kappa-opioid_receptor agonist : structural and functional considerations .
15369697	0	Salvinorin_A	0,12	kappa-opioid_receptor	43,64	Salvinorin A	kappa-opioid receptor	MESH:C090499	4986	Chemical	Gene	START_ENTITY|dep|agonist agonist|amod|END_ENTITY	Salvinorin_A : a novel and highly selective kappa-opioid_receptor agonist .
26441647	0	Salvinorin_A	0,12	kappa-opioid_receptor	16,37	Salvinorin A	kappa-opioid receptor	MESH:C090499	4986	Chemical	Gene	START_ENTITY|appos|hallucinogen hallucinogen|amod|END_ENTITY	Salvinorin_A , a kappa-opioid_receptor agonist hallucinogen : pharmacology and potential template for novel pharmacotherapeutic agents in neuropsychiatric_disorders .
26648869	0	Salvinorin_A	13,25	kappa-opioid_receptor	29,50	Salvinorin A	kappa-opioid receptor	MESH:C090499	4986	Chemical	Gene	START_ENTITY|appos|hallucinogen hallucinogen|amod|END_ENTITY	Corrigendum : Salvinorin_A , a kappa-opioid_receptor agonist hallucinogen : pharmacology and potential template for novel pharmacotherapeutic agents in neuropsychiatric_disorders .
12628350	0	Salvinorin_A	0,12	kappa_opioid_receptor	76,97	Salvinorin A	kappa opioid receptor	MESH:C090499	4986	Chemical	Gene	START_ENTITY|parataxis|finds finds|dobj|target target|nmod|END_ENTITY	Salvinorin_A : the `` magic mint '' hallucinogen finds a molecular target in the kappa_opioid_receptor .
22911847	0	Salvinorin_A	0,12	kappa_opioid_receptor	112,133	Salvinorin A	kappa opioid receptor	MESH:C090499	4986	Chemical	Gene	administration|compound|START_ENTITY administration|parataxis|preserves preserves|dobj|autoregulation autoregulation|nmod|END_ENTITY	Salvinorin_A administration after global cerebral_hypoxia / ischemia preserves cerebrovascular autoregulation via kappa_opioid_receptor in piglets .
11081188	1	Sandostatin	86,97	LAR	98,101	Sandostatin	LAR	MESH:D015282	5792	Chemical	Gene	Group|compound|START_ENTITY Group|compound|END_ENTITY	Sandostatin LAR Group .
16954816	0	Sanguinarine	0,12	AT1a	27,31	Sanguinarine	AT1a	MESH:C005705	24180(Tax:10116)	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	Sanguinarine downregulates AT1a gene expression in a hypertensive rat model .
23660334	0	Sanguinarine	0,12	Egr-1	93,98	Sanguinarine	Egr-1	MESH:C005705	1958	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|compound|END_ENTITY	Sanguinarine induces apoptosis in human colorectal_cancer HCT-116 cells through ROS-mediated Egr-1 activation and mitochondrial_dysfunction .
25354369	0	Sanguinarine	49,61	Lysozyme	65,73	Sanguinarine	Lysozyme	MESH:C005705	4069	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of the Iminium and Alkanolamine Forms of Sanguinarine to Lysozyme : Spectroscopic Analysis , Thermodynamics and Molecular Modeling Studies .
24649171	0	Sanguinarine	0,12	VEGF	24,28	Sanguinarine	VEGF	MESH:C005705	7422	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|compound|END_ENTITY	Sanguinarine is a novel VEGF inhibitor involved in the suppression of angiogenesis and cell migration .
23762849	0	Sanguinarine	0,12	vascular_endothelial_growth_factor	22,56	Sanguinarine	vascular endothelial growth factor	MESH:C005705	7422	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|compound|END_ENTITY	Sanguinarine inhibits vascular_endothelial_growth_factor release by generation of reactive oxygen species in MCF-7 human mammary adenocarcinoma cells .
12592380	0	Sant_7	95,101	IL-6	14,18	Sant 7	IL-6	MESH:C432252	3569	Chemical	Gene	antagonist|appos|START_ENTITY aromatase|nmod|antagonist aromatase|nsubj|Inhibition Inhibition|nmod|receptor-stimulated receptor-stimulated|compound|END_ENTITY	Inhibition of IL-6 + IL-6 soluble receptor-stimulated aromatase activity by the IL-6 antagonist , Sant_7 , in breast tissue-derived fibroblasts .
12592380	0	Sant_7	95,101	IL-6	19,23	Sant 7	IL-6	MESH:C432252	3569	Chemical	Gene	antagonist|appos|START_ENTITY aromatase|nmod|antagonist aromatase|nsubj|Inhibition Inhibition|nmod|receptor-stimulated receptor-stimulated|compound|END_ENTITY	Inhibition of IL-6 + IL-6 soluble receptor-stimulated aromatase activity by the IL-6 antagonist , Sant_7 , in breast tissue-derived fibroblasts .
12592380	0	Sant_7	95,101	IL-6	78,82	Sant 7	IL-6	MESH:C432252	3569	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	Inhibition of IL-6 + IL-6 soluble receptor-stimulated aromatase activity by the IL-6 antagonist , Sant_7 , in breast tissue-derived fibroblasts .
24164245	0	Santacruzamate_A	0,16	histone_deacetylase	41,60	Santacruzamate A	histone deacetylase	null	9734	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Santacruzamate_A , a potent and selective histone_deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp .
19641779	0	Saponins	0,8	TNF-alpha	18,27	Saponins	TNF-alpha	MESH:D012503	7124	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Saponins as novel TNF-alpha inhibitors : isolation of saponins and a nor-pseudoguaianolide from Parthenium hysterophorus .
19807157	0	Saponins	0,8	iNOS	99,103	Saponins	iNOS	MESH:D012503	51477	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|END_ENTITY	Saponins in yerba mate tea -LRB- Ilex paraguariensis A. St.-Hil -RRB- and quercetin synergistically inhibit iNOS and COX-2 in lipopolysaccharide-induced macrophages through NFkappaB pathways .
14716313	0	Saposin_C	0,9	CD1b	54,58	Saposin C	CD1b	MESH:D049231	910	Chemical	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	Saposin_C is required for lipid presentation by human CD1b .
14525546	0	Saquinavir	0,10	CD4	105,108	Saquinavir	CD4	MESH:D019258	920	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|P-glycoprotein P-glycoprotein|nmod|cells cells|compound|END_ENTITY	Saquinavir induces stable and functional expression of the multidrug transporter P-glycoprotein in human CD4 T-lymphoblastoid CEMrev cells .
14525546	0	Saquinavir	0,10	P-glycoprotein	81,95	Saquinavir	P-glycoprotein	MESH:D019258	5243	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Saquinavir induces stable and functional expression of the multidrug transporter P-glycoprotein in human CD4 T-lymphoblastoid CEMrev cells .
9732409	0	Saquinavir	0,10	P-glycoprotein	57,71	Saquinavir	P-glycoprotein	MESH:D019258	5243	Chemical	Gene	transported|nsubjpass|START_ENTITY transported|nmod|END_ENTITY	Saquinavir , an HIV protease inhibitor , is transported by P-glycoprotein .
1077787	0	Saralasin	67,76	angiotensin_II	24,38	Saralasin	angiotensin II	MESH:D012504	24179(Tax:10116)	Chemical	Gene	interference|nmod|START_ENTITY formation|dep|interference formation|nmod|END_ENTITY	Intrarenal formation of angiotensin_II in the rat : interference by Saralasin and SQ_20881 .
3019595	0	Saralasin	0,9	angiotensin_II	31,45	Saralasin	angiotensin II	MESH:D012504	24179(Tax:10116)	Chemical	Gene	blocks|nsubj|START_ENTITY blocks|dobj|effect effect|nmod|expansion expansion|compound|END_ENTITY	Saralasin blocks the effect of angiotensin_II and extracellular fluid saline expansion on the Na-K-ATPase inhibitor release in rats .
6525521	0	Saralasin	0,9	angiotensin_II	65,79	Saralasin	angiotensin II	MESH:D012504	24179(Tax:10116)	Chemical	Gene	activity|compound|START_ENTITY inhibited|nsubj|activity inhibited|nmod|END_ENTITY	Saralasin increases activity of hippocampal neurons inhibited by angiotensin_II .
7004464	0	Saralasin	1,10	renin	32,37	Saralasin	renin	MESH:D012504	5972	Chemical	Gene	START_ENTITY|nmod|subjects subjects|nmod|END_ENTITY	-LSB- Saralasin in subjects with low renin arterial hypertension -RSB- .
23170076	0	Sarcophine-diol	0,15	COX-2	39,44	Sarcophine-diol	COX-2	MESH:C573078	17709(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Sarcophine-diol inhibits expression of COX-2 , inhibits activity of cPLA2 , enhances degradation of PLA2 and PLC -LRB- y -RRB- 1 and inhibits cell membrane permeability in mouse melanoma B16F10 cells .
12787884	0	Sarin	0,5	acetylcholinesterase	78,98	Sarin	acetylcholinesterase	MESH:D012524	83817(Tax:10116)	Chemical	Gene	START_ENTITY|dep|expression expression|nmod|mRNA mRNA|acl|coding coding|nmod|gene gene|amod|END_ENTITY	Sarin -LRB- nerve agent GB -RRB- - induced differential expression of mRNA coding for the acetylcholinesterase gene in the rat central nervous system .
24351104	0	Sarizotan	10,19	5-HT1a	23,29	Sarizotan	5-HT1a	MESH:C443959	15550(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Effect of Sarizotan , a 5-HT1a and D2-like receptor agonist , on respiration in three mouse models of Rett_syndrome .
26200496	0	Sarpogrelate	0,12	5-HT2A_Receptor	16,31	Sarpogrelate	5-HT2A Receptor	MESH:C064294	15558(Tax:10090)	Chemical	Gene	START_ENTITY|appos|Antagonist Antagonist|amod|END_ENTITY	Sarpogrelate , a 5-HT2A_Receptor Antagonist , Protects the Retina From Light-Induced Retinopathy .
26200496	0	Sarpogrelate	0,12	5-HT2A_Receptor	16,31	Sarpogrelate	5-HT2A Receptor	MESH:C064294	15558(Tax:10090)	Chemical	Gene	START_ENTITY|appos|Antagonist Antagonist|amod|END_ENTITY	Sarpogrelate , a 5-HT2A_Receptor Antagonist , Protects the Retina From Light-Induced Retinopathy .
16886837	0	Sarpogrelate	0,12	5-hT2A_receptor	16,31	Sarpogrelate	5-hT2A receptor	MESH:C064294	3356	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Sarpogrelate , a 5-hT2A_receptor antagonist in intermittent_claudication .
12213354	0	Sarpogrelate_hydrochloride	0,26	serotonin2A_receptor	30,50	Sarpogrelate hydrochloride	serotonin2A receptor	null	3356	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Sarpogrelate_hydrochloride , a serotonin2A_receptor antagonist , reduces albuminuria in diabetic patients with early-stage diabetic_nephropathy .
26304124	0	Saturated_Fatty_Acids	0,21	HAMP	64,68	Saturated Fatty Acids	HAMP	MESH:D005227	57817	Chemical	Gene	Regulation|compound|START_ENTITY Regulation|nmod|mRNA mRNA|compound|END_ENTITY	Saturated_Fatty_Acids Induce Post-transcriptional Regulation of HAMP mRNA via AU-rich Element Binding Protein , HuR .
24382222	0	Saturated_fatty_acid	0,20	nucleotide-binding_oligomerization_domain_1	66,109	Saturated fatty acid	nucleotide-binding oligomerization domain 1	CHEBI:26607	107607(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Saturated_fatty_acid induces insulin resistance partially through nucleotide-binding_oligomerization_domain_1 signaling pathway in adipocytes .
24221358	0	Saturated_fatty_acids	0,21	COX-2	34,39	Saturated fatty acids	COX-2	MESH:D005227	5743	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Saturated_fatty_acids up-regulate COX-2 expression in prostate epithelial cells via toll-like_receptor_4 / NF-kB signaling .
18713797	0	Saturated_fatty_acids	0,21	insulin_receptor	67,83	Saturated fatty acids	insulin receptor	MESH:D005227	16337(Tax:10090)	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|advcl|modulating modulating|dobj|expression expression|compound|END_ENTITY	Saturated_fatty_acids inhibit hepatic insulin action by modulating insulin_receptor expression and post-receptor signalling .
18687301	0	Saucerneol_D	0,12	iNOS	71,75	Saucerneol D	iNOS	MESH:C561428	18126(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Saucerneol_D , a naturally occurring sesquilignan , inhibits LPS-induced iNOS expression in RAW264 .7 cells by blocking NF-kappaB and MAPK activation .
22155103	0	Saucerneol_F	0,12	iNOS	37,41	Saucerneol F	iNOS	MESH:C572382	18126(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Saucerneol_F , a new lignan , inhibits iNOS expression via MAPKs , NF-kB and AP-1 inactivation in LPS-induced RAW264 .7 cells .
21139230	0	Saucerneol_G	0,12	matrix_metalloproteinase-9	61,87	Saucerneol G	matrix metalloproteinase-9	MESH:C559485	17395(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|induction induction|amod|END_ENTITY	Saucerneol_G , a new lignan , from Saururus chinensis inhibits matrix_metalloproteinase-9 induction via a nuclear factor kB and mitogen activated protein kinases in lipopolysaccharide-stimulated RAW264 .7 cells .
14750024	0	Sauchinone	0,10	iNOS	57,61	Sauchinone	iNOS	MESH:C410958	18126(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Sauchinone , a lignan from Saururus chinensis , suppresses iNOS expression through the inhibition of transactivation activity of RelA of NF-kappaB .
20601190	0	Sauchinone	0,10	tumor_necrosis_factor-alpha	54,81	Sauchinone	tumor necrosis factor-alpha	MESH:C410958	21926(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|production production|amod|END_ENTITY	Sauchinone , a lignan from Saururus chinensis , reduces tumor_necrosis_factor-alpha production through the inhibition of c-raf/MEK1/2 / ERK_1 / 2 pathway activation .
10502470	0	Savignin	0,8	thrombin	19,27	Savignin	thrombin	null	2147	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Savignin , a potent thrombin inhibitor isolated from the salivary glands of the tick Ornithodoros savignyi -LRB- Acari : Argasidae -RRB- .
11217086	0	Savinin	0,7	tumor_necrosis_factor-alpha	55,82	Savinin	tumor necrosis factor-alpha	MESH:C425325	21926(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Savinin , a lignan from Pterocarpus santalinus inhibits tumor_necrosis_factor-alpha production and T cell proliferation .
19330494	0	Saxagliptin	0,11	DPP-4	19,24	Saxagliptin	DPP-4	MESH:C502994	1803	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Saxagliptin : a new DPP-4 inhibitor for the treatment of type_2_diabetes_mellitus .
21332626	0	Saxagliptin	0,11	DPP-4	46,51	Saxagliptin	DPP-4	MESH:C502994	1803	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Saxagliptin , a potent , selective inhibitor of DPP-4 , does not alter the pharmacokinetics of three oral_antidiabetic_drugs -LRB- metformin , glyburide or pioglitazone -RRB- in healthy subjects .
22879789	0	Saxagliptin	0,11	DPP-4	25,30	Saxagliptin	DPP-4	MESH:C502994	1803	Chemical	Gene	START_ENTITY|dep|Inhibitor Inhibitor|compound|END_ENTITY	Saxagliptin : A Selective DPP-4 Inhibitor for the Treatment of Type_2_Diabetes_Mellitus .
19444391	0	Saxagliptin	0,11	dipeptidyl_peptidase-4	19,41	Saxagliptin	dipeptidyl peptidase-4	MESH:C502994	1803	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Saxagliptin : a new dipeptidyl_peptidase-4 inhibitor for the treatment of type 2 diabetes .
20539105	0	Saxagliptin	0,11	dipeptidyl_peptidase-4	19,41	Saxagliptin	dipeptidyl peptidase-4	MESH:C502994	1803	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Saxagliptin : a new dipeptidyl_peptidase-4 inhibitor for type 2 diabetes .
20811029	0	Saxagliptin	0,11	dipeptidyl_peptidase-4	15,37	Saxagliptin	dipeptidyl peptidase-4	MESH:C502994	1803	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Saxagliptin : a dipeptidyl_peptidase-4 inhibitor for the treatment of type_2_diabetes_mellitus .
23603201	0	Saxagliptin	0,11	dipeptidyl_peptidase-4	15,37	Saxagliptin	dipeptidyl peptidase-4	MESH:C502994	25253(Tax:10116)	Chemical	Gene	START_ENTITY|dep|streptozotocin streptozotocin|amod|END_ENTITY	Saxagliptin : a dipeptidyl_peptidase-4 inhibitor ameliorates streptozotocin induced Alzheimer 's _ disease .
20460554	0	Saxagliptin	0,11	dipeptidyl_peptidase_4	19,41	Saxagliptin	dipeptidyl peptidase 4	MESH:C502994	1803	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Saxagliptin : a new dipeptidyl_peptidase_4 inhibitor for type 2 diabetes .
16257208	0	Saxagliptin	188,199	dipeptidyl_peptidase_IV	154,177	Saxagliptin	dipeptidyl peptidase IV	MESH:C502994	1803	Chemical	Gene	START_ENTITY|amod|intermediate intermediate|nmod|inhibitor inhibitor|amod|END_ENTITY	Biocatalytic ammonolysis of -LRB- 5S -RRB- -4,5 - dihydro-1H-pyrrole-1 ,5 - dicarboxylic_acid , 1 - -LRB- 1,1-dimethylethyl -RRB- -5 - ethyl_ester : preparation of an intermediate to the dipeptidyl_peptidase_IV inhibitor Saxagliptin .
19051153	0	Saxagliptin	0,11	dipeptidyl_peptidase_IV	15,38	Saxagliptin	dipeptidyl peptidase IV	MESH:C502994	1803	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Saxagliptin , a dipeptidyl_peptidase_IV inhibitor for the treatment of type 2 diabetes .
11585438	2	Sch-350634	215,225	CCR5	259,263	Sch-350634	CCR5	MESH:C438584	1234	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Discovery of 1 - -LSB- -LRB- 2,4-dimethyl-3-pyridinyl -RRB- carbonyl -RSB- -4 - _ methyl-4 - -LSB- 3 -LRB- S -RRB- - methyl-4 - -LSB- 1 -LRB- S -RRB- - -LSB- 4 - -LRB- trifluoromethyl -RRB- phenyl -RSB- ethyl -RSB- -1 - piperazinyl -RSB- - piperidine_N1-oxide -LRB- Sch-350634 -RRB- , an orally bioavailable , potent CCR5 antagonist .
15115380	2	Sch-417690	215,225	CCR5	286,290	Sch-417690	CCR5	MESH:C486781	1234	Chemical	Gene	Sch-D|compound|START_ENTITY -RSB-|appos|Sch-D -RSB-|appos|antagonist antagonist|compound|END_ENTITY	Discovery of 1 - -LSB- -LRB- 4,6-dimethyl-5-pyrimidinyl -RRB- carbonyl -RSB- - 4 - -LSB- 4 - -LSB- 2-methoxy-1 -LRB- R -RRB- -4 - -LRB- trifluoromethyl -RRB- phenyl -RSB- ethyl-3 -LRB- S -RRB- - methyl-1-piperazinyl -RSB- - _ 4-methylpiperidine -LRB- Sch-417690 / Sch-D -RRB- , a potent , highly selective , and orally bioavailable CCR5 antagonist .
1672945	0	Sch_23390	38,47	dopamine_D1_receptor	61,81	Sch 23390	dopamine D1 receptor	MESH:C534628	1812	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Lack of acute antipsychotic effect of Sch_23390 , a selective dopamine_D1_receptor antagonist .
1386887	0	Sch_40120	39,48	5-lipoxygenase	13,27	Sch 40120	5-lipoxygenase	MESH:C076031	11689(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Actions of a 5-lipoxygenase inhibitor , Sch_40120 , on acute inflammatory responses .
10353830	0	Schiff_base	43,54	rhodopsin	107,116	Schiff base	rhodopsin	MESH:D012545	6010	Chemical	Gene	counterion|compound|START_ENTITY counterion|nmod|END_ENTITY	Solid state 15N NMR evidence for a complex Schiff_base counterion in the visual G-protein-coupled receptor rhodopsin .
12484764	0	Schiff_base	26,37	rhodopsin	99,108	Schiff base	rhodopsin	MESH:D012545	6010	Chemical	Gene	START_ENTITY|dep|influence influence|nmod|environment environment|nmod|geometry geometry|nmod|chromophore chromophore|compound|END_ENTITY	11-cis-retinal protonated Schiff_base : influence of the protein environment on the geometry of the rhodopsin chromophore .
1329948	0	Schiff_base	29,40	rhodopsin	55,64	Schiff base	rhodopsin	MESH:D012545	509933(Tax:9913)	Chemical	Gene	counterion|compound|START_ENTITY location|nmod|counterion Changing|dobj|location Changing|nmod|END_ENTITY	Changing the location of the Schiff_base counterion in rhodopsin .
1337211	0	Schiff_base	120,131	rhodopsin	80,89	Schiff base	rhodopsin	MESH:D012545	509933(Tax:9913)	Chemical	Gene	evidence|nmod|START_ENTITY angle|dep|evidence angle|acl|spinning spinning|nmod|metarhodopsin metarhodopsin|nmod|END_ENTITY	Magic angle spinning NMR studies on the metarhodopsin II intermediate of bovine rhodopsin : evidence for an unprotonated Schiff_base .
14611935	0	Schiff_base	45,56	rhodopsin	104,113	Schiff base	rhodopsin	MESH:D012545	6010	Chemical	Gene	stability|amod|START_ENTITY influence|dobj|stability elements|acl:relcl|influence Assessing|dobj|elements Assessing|parataxis|destabilize destabilize|dobj|END_ENTITY	Assessing structural elements that influence Schiff_base stability : mutants E113Q and D190N destabilize rhodopsin through different mechanisms .
15322129	0	Schiff_base	107,118	rhodopsin	14,23	Schiff base	rhodopsin	MESH:D012545	6010	Chemical	Gene	isomerization|compound|START_ENTITY linked|nmod|isomerization pathway|acl|linked opens|dobj|pathway opens|nsubj|Transition Transition|nmod|END_ENTITY	Transition of rhodopsin into the active metarhodopsin II state opens a new light-induced pathway linked to Schiff_base isomerization .
15475355	0	Schiff_base	55,66	rhodopsin	45,54	Schiff base	rhodopsin	MESH:D012545	6010	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|network network|nmod|END_ENTITY	Role of the retinal hydrogen bond network in rhodopsin Schiff_base stability and hydrolysis .
16156642	0	Schiff_base	116,127	rhodopsin	60,69	Schiff base	rhodopsin	MESH:D012545	6010	Chemical	Gene	water|nmod|START_ENTITY bond|nmod|water spectroscopy|dep|bond spectroscopy|nmod|form form|nmod|END_ENTITY	FTIR spectroscopy of the all-trans form of Anabaena sensory rhodopsin at 77 K : hydrogen bond of a water between the Schiff_base and Asp75 .
16503639	0	Schiff_base	26,37	rhodopsin	54,63	Schiff base	rhodopsin	MESH:D012545	509933(Tax:9913)	Chemical	Gene	region|amod|START_ENTITY region|nmod|END_ENTITY	Structural changes in the Schiff_base region of squid rhodopsin upon photoisomerization studied by low-temperature FTIR spectroscopy .
16895417	0	Schiff_base	76,87	rhodopsin	11,20	Schiff base	rhodopsin	MESH:D012545	6010	Chemical	Gene	pKa|nmod|START_ENTITY altering|dobj|pKa activation|advcl|altering activation|csubj|Modulating Modulating|dobj|receptor receptor|compound|END_ENTITY	Modulating rhodopsin receptor activation by altering the pKa of the retinal Schiff_base .
2014228	0	Schiff_base	29,40	rhodopsin	55,64	Schiff base	rhodopsin	MESH:D012545	509933(Tax:9913)	Chemical	Gene	role|nmod|START_ENTITY counterion|nsubj|role counterion|nmod|END_ENTITY	The role of the retinylidene Schiff_base counterion in rhodopsin in determining wavelength absorbance and Schiff_base pKa .
2105232	0	Schiff_base	58,69	rhodopsin	117,126	Schiff base	rhodopsin	MESH:D012545	509933(Tax:9913)	Chemical	Gene	protonation|compound|START_ENTITY protonation|nmod|END_ENTITY	Asp83 , Glu113 and Glu134 are not specifically involved in Schiff_base protonation or wavelength regulation in bovine rhodopsin .
23701524	0	Schiff_base	47,58	rhodopsin	62,71	Schiff base	rhodopsin	MESH:D012545	6010	Chemical	Gene	pKa|nmod|START_ENTITY governs|dobj|pKa governs|nmod|activation activation|compound|END_ENTITY	Retinal conformation governs pKa of protonated Schiff_base in rhodopsin activation .
2573063	0	Schiff_base	45,56	rhodopsin	78,87	Schiff base	rhodopsin	MESH:D012545	509933(Tax:9913)	Chemical	Gene	counterion|compound|START_ENTITY counterion|nmod|END_ENTITY	Glutamic_acid-113 serves as the retinylidene Schiff_base counterion in bovine rhodopsin .
3427083	0	Schiff_base	15,26	rhodopsin	42,51	Schiff base	rhodopsin	MESH:D012545	509933(Tax:9913)	Chemical	Gene	mode|compound|START_ENTITY study|nmod|mode study|nmod|END_ENTITY	A study of the Schiff_base mode in bovine rhodopsin and bathorhodopsin .
7213657	0	Schiff_base	44,55	rhodopsin	70,79	Schiff base	rhodopsin	MESH:D012545	6010	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of phospholipid and detergent on the Schiff_base of cephalopod rhodopsin and metarhodopsin .
7916209	0	Schiff_base	43,54	rhodopsin	116,125	Schiff base	rhodopsin	MESH:D012545	509933(Tax:9913)	Chemical	Gene	acceptor|compound|START_ENTITY Identification|nmod|acceptor Identification|nmod|photointermediate photointermediate|nmod|END_ENTITY	Identification of glutamic_acid 113 as the Schiff_base proton acceptor in the metarhodopsin II photointermediate of rhodopsin .
7947779	0	Schiff_base	50,61	rhodopsin	9,18	Schiff base	rhodopsin	MESH:D012545	6010	Chemical	Gene	photoproduct|nmod|START_ENTITY photoproduct|compound|END_ENTITY	A mutant rhodopsin photoproduct with a protonated Schiff_base displays an active-state conformation : a Fourier-transform infrared spectroscopy study .
8068654	0	Schiff_base	104,115	rhodopsin	63,72	Schiff base	rhodopsin	MESH:D012545	6010	Chemical	Gene	transducin|compound|START_ENTITY photoproduct|nmod|transducin photoproduct|compound|END_ENTITY	Characterization of rhodopsin-transducin interaction : a mutant rhodopsin photoproduct with a protonated Schiff_base activates transducin .
8105993	0	Schiff_base	39,50	rhodopsin	65,74	Schiff base	rhodopsin	MESH:D012545	6010	Chemical	Gene	counterion|amod|START_ENTITY protonated|dobj|counterion protonated|nmod|END_ENTITY	Localization of the retinal protonated Schiff_base counterion in rhodopsin .
8180184	0	Schiff_base	4,15	rhodopsin	73,82	Schiff base	rhodopsin	MESH:D012545	6010	Chemical	Gene	counterion|amod|START_ENTITY protonated|nsubjpass|counterion protonated|nmod|I I|compound|END_ENTITY	The Schiff_base counterion of bacteriorhodopsin is protonated in sensory rhodopsin I : spectroscopic and functional characterization of the mutated proteins D76N and D76A .
8391868	0	Schiff_base	22,33	rhodopsin	44,53	Schiff base	rhodopsin	MESH:D012545	509933(Tax:9913)	Chemical	Gene	pKa|nmod|START_ENTITY pKa|nmod|END_ENTITY	pKa of the protonated Schiff_base of bovine rhodopsin .
8444840	0	Schiff_base	29,40	rhodopsin	55,64	Schiff base	rhodopsin	MESH:D012545	509933(Tax:9913)	Chemical	Gene	counterion|compound|START_ENTITY counterion|nmod|END_ENTITY	Movement of the retinylidene Schiff_base counterion in rhodopsin by one helix turn reverses the pH dependence of the metarhodopsin_I to metarhodopsin_II transition .
9047297	0	Schiff_base	78,89	rhodopsin	68,77	Schiff base	rhodopsin	MESH:D012545	6010	Chemical	Gene	mutants|compound|START_ENTITY mutants|amod|END_ENTITY	Time-resolved spectroscopy of the early photolysis intermediates of rhodopsin Schiff_base counterion mutants .
24486109	0	Schiff_bases	64,76	Hsp90	80,85	Schiff bases	Hsp90	MESH:D012545	3320	Chemical	Gene	evaluation|nmod|START_ENTITY docking|dobj|evaluation docking|nmod|inhibitors inhibitors|amod|END_ENTITY	Molecular docking study , synthesis and biological evaluation of Schiff_bases as Hsp90 inhibitors .
25727264	0	Schiff_bases	35,47	Hsp90	66,71	Schiff bases	Hsp90	MESH:D012545	3320	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	2,4-dihydroxy _ benzaldehyde derived Schiff_bases as small molecule Hsp90 inhibitors : Rational identification of a new anticancer lead .
23098054	0	Schiff_bases	119,131	NEt2	95,99	Schiff bases	NEt2	MESH:D012545	23554	Chemical	Gene	groups|nmod|START_ENTITY groups|amod|END_ENTITY	Proton transfer assisted charge transfer phenomena in photochromic Schiff_bases and effect of - NEt2 groups to the anil Schiff_bases .
16084496	0	Schisandrin_B	0,13	P-glycoprotein	36,50	Schisandrin B	P-glycoprotein	MESH:C015499	5243	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	Schisandrin_B -- a novel inhibitor of P-glycoprotein .
16621244	0	Schisandrin_B	0,13	P-glycoprotein	35,49	Schisandrin B	P-glycoprotein	MESH:C015499	5243	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	Schisandrin_B : a dual inhibitor of P-glycoprotein and multidrug_resistance-associated_protein_1 .
26307448	0	Schisandrin_B	0,13	thioredoxin	39,50	Schisandrin B	thioredoxin	MESH:C015499	7295	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Schisandrin_B induces an Nrf2-mediated thioredoxin expression and suppresses the activation of inflammasome in vitro and in vivo .
25793965	0	Scopadulciol	0,12	b-Catenin	53,62	Scopadulciol	b-Catenin	MESH:C071755	1499	Chemical	Gene	Induces|nsubj|START_ENTITY Induces|dobj|Degradation Degradation|amod|END_ENTITY	Scopadulciol , Isolated from Scoparia dulcis , Induces b-Catenin Degradation and Overcomes Tumor_Necrosis_Factor-Related_Apoptosis_Ligand Resistance in AGS Human Gastric_Adenocarcinoma Cells .
16376386	0	Scoparone	0,9	IL-8	31,35	Scoparone	IL-8	MESH:C018145	3576	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Scoparone inhibits PMA-induced IL-8 and MCP-1 production through suppression of NF-kappaB activation in U937 cells .
1393566	0	Scopolamine	0,11	c-fos	43,48	Scopolamine	c-fos	MESH:D012601	2353	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|amod|END_ENTITY	Scopolamine attenuates haloperidol-induced c-fos expression in the striatum .
8861055	0	Scopolamine	0,11	c-fos	21,26	Scopolamine	c-fos	MESH:D012601	314322(Tax:10116)	Chemical	Gene	augments|nsubj|START_ENTITY augments|dobj|expression expression|amod|END_ENTITY	Scopolamine augments c-fos and zip/268 messenger RNA expression induced by the full D -LRB- 1 -RRB- dopamine receptor agonist SKF-82958 in the intact rat striatum .
24223475	0	Scutellarin	0,11	Toll-like_receptor_4	64,84	Scutellarin	Toll-like receptor 4	MESH:C484876	29260(Tax:10116)	Chemical	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Scutellarin attenuates hypertension-induced expression of brain Toll-like_receptor_4 / nuclear factor kappa B. Hypertension is associated with low-grade inflammation , and Toll-like_receptor_4 -LRB- TLR4 -RRB- has been shown to be linked to the development and maintenance of hypertension .
22228482	0	Scutellarin	0,11	cytochrome_P450_isoenzyme_1A2	21,50	Scutellarin	cytochrome P450 isoenzyme 1A2	MESH:C484876	24297(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Scutellarin inhibits cytochrome_P450_isoenzyme_1A2 -LRB- CYP1A2 -RRB- in rats .
26589745	0	Se	32,34	FOXP3	67,72	Se	FOXP3	null	50943	Chemical	Gene	Localization|compound|START_ENTITY Localization|nmod|END_ENTITY	Comment on `` mTOR Inhibition Per Se Induces Nuclear Localization of FOXP3 and Conversion of Invariant NKT -LRB- iNKT -RRB- Cells into Immunosuppressive Regulatory iNKT Cells '' .
26589746	0	Se	44,46	FOXP3	79,84	Se	FOXP3	null	50943	Chemical	Gene	Localization|compound|START_ENTITY Localization|nmod|END_ENTITY	Response to Comment on `` mTOR Inhibition Per Se Induces Nuclear Localization of FOXP3 and Conversion of Invariant NKT -LRB- iNKT -RRB- Cells into Immunosuppressive Regulatory iNKT Cells '' .
7688530	0	Se	39,41	glutathione_S-transferase	45,70	Se	glutathione S-transferase	null	395863(Tax:9031)	Chemical	Gene	START_ENTITY|nmod|activities activities|amod|END_ENTITY	Effects of aurothioglucose and dietary Se on glutathione_S-transferase activities and glutathione concentrations in chick tissues .
16716806	0	Se-methylselenocysteine	0,23	CD11c	46,51	Se-methylselenocysteine	CD11c	MESH:C002979	3687	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Se-methylselenocysteine enhances PMA-mediated CD11c expression via phospholipase_D1 activation in U937 cells .
12223349	0	Secretin	0,8	Src	79,82	Secretin	Src	MESH:D012633	6714	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|pathway pathway|compound|END_ENTITY	Secretin regulates paracellular permeability in canine gastric monolayers by a Src kinase-dependent pathway .
8074227	0	Secretin	0,8	gastrin	67,74	Secretin	gastrin	MESH:D012633	25320(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Secretin inhibits induction of ornithine_decarboxylase activity by gastrin in duodenal mucosa and IEC-6 cells .
24328835	0	Selaginpulvilins_A-D	0,20	phosphodiesterase-4	26,45	Selaginpulvilins A-D	phosphodiesterase-4	null	5141	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Selaginpulvilins_A-D , new phosphodiesterase-4 inhibitors with an unprecedented skeleton from Selaginella pulvinata .
15953199	0	Selamectin	0,10	P-glycoprotein	67,81	Selamectin	P-glycoprotein	MESH:C414354	5243	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Selamectin is a potent substrate and inhibitor of human and canine P-glycoprotein .
15233874	0	Selegiline	0,10	MAO-B	15,20	Selegiline	MAO-B	MESH:D012642	25750(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Selegiline , an MAO-B inhibitor , attenuates airway smooth muscle contraction in the rat trachea .
25249059	0	Selegiline	61,71	MAO-B	44,49	Selegiline	MAO-B	MESH:D012642	4129	Chemical	Gene	Inhibitor|appos|START_ENTITY Inhibitor|compound|END_ENTITY	Evidence that Formulations of the Selective MAO-B Inhibitor , Selegiline , which Bypass First-Pass Metabolism , also Inhibit MAO-A in the Human Brain .
25036792	0	Selenadiazole	0,13	thioredoxin_reductase	36,57	Selenadiazole	thioredoxin reductase	null	25824	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Selenadiazole derivatives as potent thioredoxin_reductase inhibitors that enhance the radiosensitivity of cancer cells .
23769801	0	Selenate	0,8	AKT	90,93	Selenate	AKT	MESH:C055793	207	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|compound|END_ENTITY	Selenate induces epithelial-mesenchymal_transition in a colorectal_carcinoma cell line by AKT activation .
22366233	0	Selenate	0,8	LIF	120,123	Selenate	LIF	MESH:C055793	3976	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|signaling signaling|compound|END_ENTITY	Selenate enhances STAT3 transcriptional activity in endothelial cells : differential actions of selenate and selenite on LIF cytokine signaling and cell viability .
22974981	0	Selenate	0,8	TGF-b1	83,89	Selenate	TGF-b1	MESH:C055793	7040	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|induction induction|nmod|END_ENTITY	Selenate inhibits adipogenesis through induction of transforming_growth_factor-b1 -LRB- TGF-b1 -RRB- signaling .
12968334	0	Selenenyl_iodide	0,16	thioredoxin_reductase	48,69	Selenenyl iodide	thioredoxin reductase	null	25824	Chemical	Gene	START_ENTITY|dep|substrate substrate|nmod|END_ENTITY	Selenenyl_iodide : a new substrate for mammalian thioredoxin_reductase .
10722685	0	Selenite	0,8	caspase-3	30,39	Selenite	caspase-3	MESH:D018038	836	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	Selenite negatively regulates caspase-3 through a redox mechanism .
20428765	0	Selenite	0,8	p53	54,57	Selenite	p53	MESH:D018038	7157	Chemical	Gene	triggers|nsubj|START_ENTITY triggers|dobj|activation activation|nmod|END_ENTITY	Selenite triggers rapid transcriptional activation of p53 , and p53-mediated apoptosis in prostate_cancer cells : Implication for the treatment of early-stage prostate_cancer .
16880784	0	Selenium	0,8	CEA	75,78	Selenium	CEA	MESH:D012643	1084	Chemical	Gene	START_ENTITY|dep|correlation correlation|nmod|END_ENTITY	Selenium in serum and neoplastic tissue in breast_cancer : correlation with CEA .
16665963	0	Selenium	0,8	Glutathione_Peroxidase	23,45	Selenium	Glutathione Peroxidase	MESH:D012643	5723945(Tax:3055)	Chemical	Gene	Inducer|compound|START_ENTITY Inducer|nmod|END_ENTITY	Selenium as Inducer of Glutathione_Peroxidase in low-CO -LRB- 2 -RRB- - Grown Chlamydomonas_reinhardtii .
26743526	0	Selenium	0,8	Insulin	33,40	Selenium	Insulin	MESH:D012643	3630	Chemical	Gene	Resistance|compound|START_ENTITY Resistance|compound|END_ENTITY	Selenium Supplementation Affects Insulin Resistance and Serum hs-CRP in Patients with Type_2_Diabetes and Coronary_Heart_Disease .
15650415	0	Selenium	0,8	MnSOD	34,39	Selenium	MnSOD	MESH:D012643	6648	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|nmod|END_ENTITY	Selenium attenuates expression of MnSOD and uncoupling_protein_2 in J774 .2 macrophages : molecular mechanism for its cell-death and antiinflammatory activity .
18279804	0	Selenium	0,8	NF-kappa_B	59,69	Selenium	NF-kappa B	MESH:D012643	4790	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|activation activation|nmod|END_ENTITY	Selenium suppresses the activation of transcription factor NF-kappa_B and IRF3 induced by TLR3 or TLR4 agonists .
23830626	0	Selenium	0,8	Nrf2	40,44	Selenium	Nrf2	MESH:D012643	4780	Chemical	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Selenium in the redox regulation of the Nrf2 and the Wnt pathway .
22476978	0	Selenium	0,8	RAGE	23,27	Selenium	RAGE	MESH:D012643	362787(Tax:10116)	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	Selenium downregulates RAGE and NFkB expression in diabetic rats .
26463750	0	Selenium	61,69	Selenoprotein_W	0,15	Selenium	Selenoprotein W	MESH:D012643	100310814(Tax:9031)	Chemical	Gene	Effect|nmod|START_ENTITY Correlated|nmod|Effect Correlated|nsubjpass|END_ENTITY	Selenoprotein_W was Correlated with the Protective Effect of Selenium on Chicken Myocardial Cells from Oxidative Damage .
17047069	0	Selenium	0,8	cyclooxygenase-2	19,35	Selenium	cyclooxygenase-2	MESH:D012643	5743	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	Selenium regulates cyclooxygenase-2 and extracellular_signal-regulated_kinase signaling pathways by activating AMP-activated_protein_kinase in colon_cancer cells .
21052844	0	Selenium	0,8	cyclooxygenase-2	39,55	Selenium	cyclooxygenase-2	MESH:D012643	5743	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Selenium inhibits high glucose-induced cyclooxygenase-2 and P-selectin expression in vascular endothelial cells .
9618024	0	Selenium	0,8	estrogen_sulfotransferase	39,64	Selenium	estrogen sulfotransferase	MESH:D012643	360268(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Selenium regulates gene expression for estrogen_sulfotransferase and alpha_2U-globulin in rat liver .
8391784	0	Selenium	0,8	glutathione_peroxidase	23,45	Selenium	glutathione peroxidase	MESH:D012643	2876	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Selenium regulation of glutathione_peroxidase in human hepatoma cell line Hep3B .
19234057	0	Selenium	0,8	gpx1	72,76	Selenium	gpx1	MESH:D012643	24404(Tax:10116)	Chemical	Gene	requirements|amod|START_ENTITY higher|nsubj|requirements higher|nmod|activity activity|amod|END_ENTITY	Selenium requirements are higher for glutathione_peroxidase-1 mRNA than gpx1 activity in rat testis .
23459983	0	Selenium	0,8	interleukin-6	38,51	Selenium	interleukin-6	MESH:D012643	3569	Chemical	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	Selenium is inversely associated with interleukin-6 in the elderly .
19076066	0	Selenium	0,8	selenoprotein	33,46	Selenium	selenoprotein	MESH:D012643	93684(Tax:10090)	Chemical	Gene	status|amod|START_ENTITY regulates|nsubj|status regulates|dobj|levels levels|amod|END_ENTITY	Selenium status highly regulates selenoprotein mRNA levels for only a subset of the selenoproteins in the selenoproteome .
23468186	0	Selenium	0,8	selenoprotein	19,32	Selenium	selenoprotein	MESH:D012643	93684(Tax:10090)	Chemical	Gene	effect|amod|START_ENTITY effect|nmod|END_ENTITY	Selenium effect on selenoprotein transcriptome in chondrocytes .
21837452	0	Selenium	0,8	selenoprotein_W	38,53	Selenium	selenoprotein W	MESH:D012643	100310814(Tax:9031)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Selenium regulates gene expression of selenoprotein_W in chicken skeletal muscle system .
21863323	0	Selenium	0,8	selenoprotein_W	38,53	Selenium	selenoprotein W	MESH:D012643	100310814(Tax:9031)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Selenium regulates gene expression of selenoprotein_W in chicken gastrointestinal tract .
24422500	0	Selenium	0,8	thioredoxin_reductase	67,88	Selenium	thioredoxin reductase	MESH:D012643	25824	Chemical	Gene	START_ENTITY|nmod|mechanism mechanism|nmod|END_ENTITY	Selenium as an electron acceptor during the catalytic mechanism of thioredoxin_reductase .
518233	0	Selenium	0,8	xanthine_dehydrogenase	32,54	Selenium	xanthine dehydrogenase	MESH:D012643	7498	Chemical	Gene	requirement|amod|START_ENTITY requirement|nmod|END_ENTITY	Selenium requirement for active xanthine_dehydrogenase from Clostridium acidiurici and Clostridium cylindrosporum .
26452064	0	Selenocysteine	14,28	Selenoprotein_P	46,61	Selenocysteine	Selenoprotein P	MESH:D017279	6403	Chemical	Gene	Content|compound|START_ENTITY Content|nmod|END_ENTITY	Regulation of Selenocysteine Content of Human Selenoprotein_P by Dietary Selenium and Insertion of Cysteine in Place of Selenocysteine .
25277183	0	Selenocysteine	0,14	TRAIL	36,41	Selenocysteine	TRAIL	MESH:D017279	8743	Chemical	Gene	resistance|amod|START_ENTITY resistance|compound|END_ENTITY	Selenocysteine derivative overcomes TRAIL resistance in melanoma cells : evidence for ROS-dependent synergism and signaling crosstalk .
21880115	0	Selenodiglutathione	0,19	Ycf1p	101,106	Selenodiglutathione	Ycf1p	MESH:C017710	851713(Tax:4932)	Chemical	Gene	uptake|nsubj|START_ENTITY uptake|nmod|END_ENTITY	Selenodiglutathione uptake by the Saccharomyces_cerevisiae vacuolar ATP-binding cassette transporter Ycf1p .
15655349	0	Selenomethionine	0,16	COX-2	45,50	Selenomethionine	COX-2	MESH:D012645	5743	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|appos|END_ENTITY	Selenomethionine regulates cyclooxygenase-2 -LRB- COX-2 -RRB- expression through nuclear_factor-kappa_B -LRB- NF-kappaB -RRB- in colon_cancer cells .
15513932	0	Selenomethionine	0,16	ERK	35,38	Selenomethionine	ERK	MESH:D012645	5594	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Selenomethionine induces sustained ERK phosphorylation leading to cell-cycle arrest in human colon_cancer cells .
12539231	0	Selenomethionine	0,16	PSA	33,36	Selenomethionine	PSA	MESH:D012645	354	Chemical	Gene	affect|nsubj|START_ENTITY affect|dobj|END_ENTITY	Selenomethionine does not affect PSA secretion independent of its effect on LNCaP cell growth .
15655349	0	Selenomethionine	0,16	cyclooxygenase-2	27,43	Selenomethionine	cyclooxygenase-2	MESH:D012645	5743	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Selenomethionine regulates cyclooxygenase-2 -LRB- COX-2 -RRB- expression through nuclear_factor-kappa_B -LRB- NF-kappaB -RRB- in colon_cancer cells .
19448000	0	Selenomethionine	0,16	glutathione_peroxidase_1_and_3	42,72	Selenomethionine	glutathione peroxidase 1 and 3	MESH:D012645	281209(Tax:9913)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|nmod|END_ENTITY	Selenomethionine stimulates expression of glutathione_peroxidase_1_and_3 and growth of bovine mammary epithelial cells in primary culture .
15655349	0	Selenomethionine	0,16	nuclear_factor-kappa_B	71,93	Selenomethionine	nuclear factor-kappa B	MESH:D012645	4790	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Selenomethionine regulates cyclooxygenase-2 -LRB- COX-2 -RRB- expression through nuclear_factor-kappa_B -LRB- NF-kappaB -RRB- in colon_cancer cells .
12357032	0	Selenomethionine	0,16	p53	31,34	Selenomethionine	p53	MESH:D012645	22060(Tax:10090)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Selenomethionine regulation of p53 by a ref1-dependent redox mechanism .
16627976	0	Selenomethionine	0,16	p53	25,28	Selenomethionine	p53	MESH:D012645	7157	Chemical	Gene	induces|nsubj|START_ENTITY induces|ccomp|mediated mediated|nsubj|END_ENTITY	Selenomethionine induces p53 mediated cell cycle arrest and apoptosis in human colon_cancer cells .
17100737	0	Selenomethionine	0,16	p53	56,59	Selenomethionine	p53	MESH:D012645	7157	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|transactivation transactivation|compound|END_ENTITY	Selenomethionine inhibits ultraviolet radiation-induced p53 transactivation .
15534230	0	Selenophosphate	0,15	Sps1	65,69	Selenophosphate	Sps1	MESH:C076818	22929	Chemical	Gene	genes|amod|START_ENTITY genes|dep|END_ENTITY	Selenophosphate synthetase genes from lung_adenocarcinoma cells : Sps1 for recycling L-selenocysteine and Sps2 for selenite assimilation .
26482043	0	Selumetinib	61,72	MEK	46,49	Selumetinib	MEK	MESH:C517975	5609	Chemical	Gene	Resistance|appos|START_ENTITY Resistance|compound|END_ENTITY	MAPK Activation Predicts Poor Outcome and the MEK Inhibitor , Selumetinib , Reverses Antiestrogen Resistance in ER-Positive High-Grade Serous Ovarian_Cancer .
26446942	0	Selumetinib	28,39	MEK1/2	63,69	Selumetinib	MEK1/2	MESH:C517975	5604;5605	Chemical	Gene	Trial|appos|START_ENTITY Trial|appos|Inhibitor Inhibitor|compound|END_ENTITY	A Phase 2 Trial of AZD6244 -LRB- Selumetinib , ARRY-142886 -RRB- , an Oral MEK1/2 Inhibitor , in Relapsed/Refractory Multiple_Myeloma .
19393247	0	Sennoside_B	0,11	PDGF_receptor	21,34	Sennoside B	PDGF receptor	MESH:C002839	5159	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|signaling signaling|compound|END_ENTITY	Sennoside_B inhibits PDGF_receptor signaling and cell proliferation induced by PDGF-BB in human osteosarcoma cells .
19281809	0	Sergliflozin_etabonate	0,22	SGLT2	36,41	Sergliflozin etabonate	SGLT2	MESH:C546025	64522(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Sergliflozin_etabonate , a selective SGLT2 inhibitor , improves glycemic control in streptozotocin-induced diabetic rats and Zucker fatty rats .
9247638	0	Serine	0,6	46-kDa_mannose_6-phosphate_receptor	35,70	Serine	46-kDa mannose 6-phosphate receptor	CHEBI:17822	17113(Tax:10090)	Chemical	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Serine phosphorylation site of the 46-kDa_mannose_6-phosphate_receptor is required for transport to the plasma membrane in Madin-Darby canine kidney and mouse fibroblast cells .
25271156	0	Serine	18,24	Apelin_Receptor	36,51	Serine	Apelin Receptor	CHEBI:17822	187	Chemical	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of Serine 348 on the Apelin_Receptor as a Novel Regulatory Phosphorylation Site in Apelin-13-Induced G Protein-Independent Biased Signaling .
21757540	0	Serine	19,25	Atg32	33,38	Serine	Atg32	CHEBI:17822	854660(Tax:4932)	Chemical	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of Serine 114 on Atg32 mediates mitophagy .
9092538	0	Serine	0,6	Cbl	26,29	Serine	Cbl	CHEBI:17822	867	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Serine phosphorylation of Cbl induced by phorbol_ester enhances its association with 14-3-3 proteins in T cells via a novel serine-rich 14-3-3-binding motif .
25704183	0	Serine	28,34	EGFR	54,58	Serine	EGFR	CHEBI:17822	1956	Chemical	Gene	Phosphorylation|compound|START_ENTITY Phosphorylation|nmod|END_ENTITY	Helicobacter_pylori Induces Serine Phosphorylation of EGFR via Novel TAK1-p38 Activation Pathway in an HB-EGF-Independent Manner .
12941275	0	Serine	0,6	FAK	30,33	Serine	FAK	CHEBI:17822	14083(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Serine 732 phosphorylation of FAK by Cdk5 is important for microtubule organization , nuclear movement , and neuronal migration .
21746915	0	Serine	0,6	GATA4	51,56	Serine	GATA4	CHEBI:17822	14463(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Serine 105 phosphorylation of transcription factor GATA4 is necessary for stress-induced cardiac_hypertrophy in vivo .
14534256	0	Serine	29,35	Glutamate_receptor_subunit_2	0,28	Serine	Glutamate receptor subunit 2	CHEBI:17822	2891	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Glutamate_receptor_subunit_2 Serine 880 phosphorylation modulates synaptic transmission and mediates plasticity in CA1 pyramidal cells .
16650464	0	Serine	0,6	HTRA1	17,22	Serine	HTRA1	CHEBI:17822	5654	Chemical	Gene	proteases|nsubj|START_ENTITY proteases|ccomp|down-regulated down-regulated|nsubj|END_ENTITY	Serine proteases HTRA1 and HTRA3 are down-regulated with increasing grades of human endometrial_cancer .
24040176	0	Serine	0,6	HTRA1	111,116	Serine	HTRA1	CHEBI:17822	56213(Tax:10090)	Chemical	Gene	antagonizes|amod|START_ENTITY antagonizes|acl|transforming transforming|dobj|factor-b factor-b|acl|signaling signaling|advcl|cleaving cleaving|nmod|END_ENTITY	Serine protease HTRA1 antagonizes transforming growth factor-b signaling by cleaving its receptors and loss of HTRA1 in vivo enhances bone formation .
24040176	0	Serine	0,6	HTRA1	16,21	Serine	HTRA1	CHEBI:17822	56213(Tax:10090)	Chemical	Gene	antagonizes|amod|START_ENTITY antagonizes|compound|END_ENTITY	Serine protease HTRA1 antagonizes transforming growth factor-b signaling by cleaving its receptors and loss of HTRA1 in vivo enhances bone formation .
19470753	0	Serine	0,6	HtrA1	16,21	Serine	HtrA1	CHEBI:17822	5654	Chemical	Gene	protease|nsubj|START_ENTITY protease|dobj|associates associates|amod|END_ENTITY	Serine protease HtrA1 associates with microtubules and inhibits cell migration .
23592924	0	Serine	0,6	HtrA1	16,21	Serine	HtrA1	CHEBI:17822	5654	Chemical	Gene	accumulates|amod|START_ENTITY accumulates|amod|END_ENTITY	Serine protease HtrA1 accumulates in corneal transforming_growth_factor_beta_induced protein -LRB- TGFBIp -RRB- amyloid_deposits .
23775122	0	Serine	0,6	IRS2	32,36	Serine	IRS2	CHEBI:17822	29376(Tax:10116)	Chemical	Gene	sites|amod|START_ENTITY sites|nmod|END_ENTITY	Serine phosphorylation sites on IRS2 activated by angiotensin_II and protein kinase C to induce selective insulin resistance in endothelial cells .
26846849	0	Serine	0,6	Insulin_Receptor_Substrate_1	36,64	Serine	Insulin Receptor Substrate 1	CHEBI:17822	16367(Tax:10090)	Chemical	Gene	Phosphorylation|compound|START_ENTITY Phosphorylation|nmod|END_ENTITY	Serine 302 Phosphorylation of Mouse Insulin_Receptor_Substrate_1 -LRB- Irs1 -RRB- Is Dispensable For Normal Insulin Signaling and Feedback Regulation by Hepatic S6 Kinase .
10975838	0	Serine	0,6	Lck	12,15	Serine	Lck	CHEBI:17822	3932	Chemical	Gene	START_ENTITY|nmod|kinase kinase|compound|END_ENTITY	Serine 6 of Lck tyrosine kinase : a critical site for Lck myristoylation , membrane localization , and function in T lymphocytes .
20734105	0	Serine	0,6	MK5	52,55	Serine	MK5	CHEBI:17822	8550	Chemical	Gene	residue|amod|START_ENTITY residue|nmod|END_ENTITY	Serine residue 115 of MAPK-activated protein kinase MK5 is crucial for its PKA-regulated nuclear export and biological function .
24728176	0	Serine	18,24	Mad1	13,17	Serine	Mad1	CHEBI:17822	8379	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	ATM-mediated Mad1 Serine 214 phosphorylation regulates Mad1 dimerization and the spindle assembly checkpoint .
18521086	0	Serine	0,6	NRIF3	29,34	Serine	NRIF3	CHEBI:17822	23421	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Serine 28 phosphorylation of NRIF3 confers its co-activator function for estrogen_receptor-alpha transactivation .
10660568	0	Serine	0,6	P14	12,15	Serine	P14	CHEBI:17822	11102	Chemical	Gene	_|compound|START_ENTITY _|appos|END_ENTITY	Serine 380 -LRB- P14 -RRB- _ -- > _ glutamate mutation activates antithrombin as an inhibitor of factor_Xa .
7479852	0	Serine	0,6	P450c17	32,39	Serine	P450c17	CHEBI:17822	1586	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Serine phosphorylation of human P450c17 increases 17,20-lyase activity : implications for adrenarche and the polycystic_ovary_syndrome .
22129425	0	Serine	0,6	PICK1	31,36	Serine	PICK1	CHEBI:17822	9463	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Serine 77 in the PDZ domain of PICK1 is a protein_kinase_Ca phosphorylation site regulated by lipid membrane binding .
15299031	0	Serine	0,6	RAX	29,32	Serine	RAX	CHEBI:17822	30062	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Serine 18 phosphorylation of RAX , the PKR activator , is required for PKR activation and consequent translation inhibition .
12231506	0	Serine	0,6	RUNX2	26,31	Serine	RUNX2	CHEBI:17822	860	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Serine phosphorylation of RUNX2 with novel potential functions as negative regulatory mechanisms .
20685659	0	Serine	0,6	SRp55	46,51	Serine	SRp55	CHEBI:17822	6431	Chemical	Gene	proteins|amod|START_ENTITY proteins|dep|END_ENTITY	Serine - and arginine-rich proteins 55 and 75 -LRB- SRp55 and SRp75 -RRB- induce production of HIV-1 vpr mRNA by inhibiting the 5 ' - splice site of exon 3 .
10660304	0	Serine	0,6	STAT3	49,54	Serine	STAT3	CHEBI:17822	6774	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR .
12637318	0	Serine	0,6	STAT3	26,31	Serine	STAT3	CHEBI:17822	6774	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Serine phosphorylation of STAT3 is essential for Mcl-1 expression and macrophage survival .
19885032	0	Serine	65,71	STAT3	95,100	Serine	STAT3	CHEBI:17822	6774	Chemical	Gene	Phosphorylation|compound|START_ENTITY Phosphorylation|nmod|END_ENTITY	Extracellular Signal-regulated Kinase Activation Is Required for Serine 727 Phosphorylation of STAT3 in Schwann Cells in vitro and in vivo .
22911886	0	Serine	0,6	STAT3	30,35	Serine	STAT3	CHEBI:17822	20848(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Serine 727 phosphorylation of STAT3 : an early change in mouse hepatocarcinogenesis induced by neonatal treatment with diethylnitrosamine .
23071339	0	Serine	0,6	SYK	26,29	Serine	SYK	CHEBI:17822	6850	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Serine phosphorylation by SYK is critical for nuclear localization and transcription factor function of Ikaros .
26944060	0	Serine	26,32	SelP	75,79	Serine	SelP	CHEBI:17822	6403	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	The Synergistic Effect of Serine with Selenocompounds on the Expression of SelP and GPx in HepG2 Cells .
23891091	0	Serine	19,25	Snail	13,18	Serine	Snail	CHEBI:17822	6615	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	ATM-mediated Snail Serine 100 phosphorylation regulates cellular radiosensitivity .
16181056	0	Serine	0,6	Stat6	26,31	Serine	Stat6	CHEBI:17822	6778	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Serine phosphorylation of Stat6 negatively controls its DNA-binding function .
25972993	0	Serine	25,31	TRPV4	19,24	Serine	TRPV4	CHEBI:17822	59341	Chemical	Gene	Interaction|compound|START_ENTITY Interaction|compound|END_ENTITY	Phosphorylation on TRPV4 Serine 824 Regulates Interaction with STIM1 .
22389828	0	Serine	0,6	Tissue_Transglutaminase	59,82	Serine	Tissue Transglutaminase	CHEBI:17822	7052	Chemical	Gene	Phosphorylation|compound|START_ENTITY Phosphorylation|nmod|END_ENTITY	Serine 129 Phosphorylation of a-Synuclein Cross-Links with Tissue_Transglutaminase to Form Lewy Body-Like Inclusion Bodies .
25854427	0	Serine	35,41	Translationally_Controlled_Tumor_Protein	54,94	Serine	Translationally Controlled Tumor Protein	CHEBI:17822	7178	Chemical	Gene	Residues|compound|START_ENTITY Residues|nmod|END_ENTITY	Insulin Induces Phosphorylation of Serine Residues of Translationally_Controlled_Tumor_Protein in 293T Cells .
18562315	0	Serine	0,6	alpha-synuclein	30,45	Serine	alpha-synuclein	CHEBI:17822	6622	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Serine 129 phosphorylation of alpha-synuclein induces unfolded protein response-mediated cell death .
10409710	0	Serine	0,6	beta-platelet-derived_growth_factor_receptor	47,91	Serine	beta-platelet-derived growth factor receptor	CHEBI:17822	24629(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Serine phosphorylation of the ligand-activated beta-platelet-derived_growth_factor_receptor by casein kinase I-gamma2 inhibits the receptor 's autophosphorylating activity .
17253643	0	Serine	0,6	casein_kinase_II	26,42	Serine	casein kinase II	CHEBI:17822	1457	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Serine phosphorylation by casein_kinase_II controls endocytic L1 trafficking and axon growth .
18081315	0	Serine	0,6	caveolin-2	36,46	Serine	caveolin-2	CHEBI:17822	858	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Serine 23 and 36 phosphorylation of caveolin-2 is differentially regulated by targeting to lipid raft/caveolae and in mitotic endothelial cells .
10563826	0	Serine	0,6	eIF2_alpha	40,50	Serine	eIF2 alpha	CHEBI:17822	100338417(Tax:9986)	Chemical	Gene	START_ENTITY|nmod|factor factor|appos|END_ENTITY	Serine 48 in initiation factor 2 alpha -LRB- eIF2_alpha -RRB- is required for high-affinity interaction between eIF2_alpha -LRB- P -RRB- and eIF2B .
26130148	0	Serine	41,47	eIF2a	35,40	Serine	eIF2a	CHEBI:17822	1965	Chemical	Gene	Phosphorylation|compound|START_ENTITY Phosphorylation|amod|END_ENTITY	mTORC2 Balances AKT Activation and eIF2a Serine 51 Phosphorylation to Promote Survival under Stress .
19160501	0	Serine	0,6	ephrinB2	26,34	Serine	ephrinB2	CHEBI:17822	13642(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Serine phosphorylation of ephrinB2 regulates trafficking of synaptic AMPA receptors .
24386386	0	Serine	0,6	estrogen_receptor_a	30,49	Serine	estrogen receptor a	CHEBI:17822	13982(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Serine 216 phosphorylation of estrogen_receptor_a in neutrophils : migration and infiltration into the mouse uterus .
11160818	0	Serine	0,6	focal_adhesion_kinase	26,47	Serine	focal adhesion kinase	CHEBI:17822	14083(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Serine phosphorylation of focal_adhesion_kinase in interphase and mitosis : a possible role in modulating binding to p130 -LRB- Cas -RRB- .
20654585	0	Serine	0,6	glutathione_S-transferase_P1	26,54	Serine	glutathione S-transferase P1	CHEBI:17822	2950	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Serine phosphorylation of glutathione_S-transferase_P1 -LRB- GSTP1 -RRB- by PKCa enhances GSTP1-dependent cisplatin metabolism and resistance in human glioma cells .
12792516	0	Serine	0,6	granzyme_B	56,66	Serine	granzyme B	CHEBI:17822	3002	Chemical	Gene	inhibitor-9|amod|START_ENTITY inhibitor-9|appos|blocker blocker|nmod|pathway pathway|amod|END_ENTITY	Serine proteinase inhibitor-9 , an endogenous blocker of granzyme_B / perforin lytic pathway , is hyperexpressed during acute rejection of renal allografts .
12351658	0	Serine	0,6	insulin_receptor_substrate_1	26,54	Serine	insulin receptor substrate 1	CHEBI:17822	3667	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Serine phosphorylation of insulin_receptor_substrate_1 by inhibitor kappa B kinase complex .
15272003	0	Serine	0,6	lipoprotein_receptor-related_protein	56,92	Serine	lipoprotein receptor-related protein	CHEBI:17822	4035	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Serine and threonine phosphorylation of the low density lipoprotein_receptor-related_protein by protein kinase Calpha regulates endocytosis and association with adaptor molecules .
15298678	0	Serine	0,6	mCRY1	26,31	Serine	mCRY1	CHEBI:17822	12952(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Serine phosphorylation of mCRY1 and mCRY2 by mitogen-activated protein kinase .
17967874	0	Serine	0,6	p53	29,32	Serine	p53	CHEBI:17822	7157	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Serine 15 phosphorylation of p53 directs its interaction with B56gamma and the tumor suppressor activity of B56gamma-specific protein phosphatase 2A .
7757994	0	Serine	0,6	p53	46,49	Serine	p53	CHEBI:17822	301300(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|terminus terminus|nmod|END_ENTITY	Serine phosphorylation in the NH2 terminus of p53 facilitates transactivation .
16155364	0	Serine	0,6	phospholemman	10,23	Serine	phospholemman	CHEBI:17822	100623939	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Serine 68 phospholemman phosphorylation during forskolin-induced swine carotid artery relaxation .
2448305	0	Serine	82,88	pp_12	72,77	Serine	pp 12	CHEBI:17822	3484	Chemical	Gene	protein|nmod|START_ENTITY protein|appos|END_ENTITY	Site-directed mutagenesis of the avian retrovirus nucleocapsid protein , pp_12 , at Serine 40 , the primary site of phosphorylation in vivo .
10536068	0	Serine	0,6	proteinase	7,17	Serine	proteinase	CHEBI:17822	100616101	Chemical	Gene	therapy|amod|START_ENTITY therapy|amod|END_ENTITY	Serine proteinase inhibitor therapy in alpha -LRB- 1 -RRB- - antitrypsin inhibitor deficiency and cystic_fibrosis .
11731617	0	Serine	0,6	signal_transducer_and_activator_of_transcription_5a	39,90	Serine	signal transducer and activator of transcription 5a	CHEBI:17822	6776	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Serine phosphorylation of GH-activated signal_transducer_and_activator_of_transcription_5a -LRB- STAT5a -RRB- and STAT5b : impact on STAT5 transcriptional activity .
9605566	0	Serine-O-sulphate	0,17	EAAT2	64,69	Serine-O-sulphate	EAAT2	null	6506	Chemical	Gene	transport|amod|START_ENTITY transport|nmod|transporter transporter|appos|END_ENTITY	Serine-O-sulphate transport by the human glutamate transporter , EAAT2 .
33382	0	Serine-borate	0,13	gamma-glutamyl_transpeptidase	57,86	Serine-borate	gamma-glutamyl transpeptidase	null	92086	Chemical	Gene	complex|amod|START_ENTITY complex|nmod|END_ENTITY	Serine-borate complex as a transition-state inhibitor of gamma-glutamyl_transpeptidase .
9753655	0	Serines	0,7	11_beta-hydroxysteroid_dehydrogenase_type_I	30,73	Serines	11 beta-hydroxysteroid dehydrogenase type I	null	25116(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|site site|nmod|END_ENTITY	Serines at the active site of 11_beta-hydroxysteroid_dehydrogenase_type_I determine the rate of catalysis .
10094235	0	Serotonin	0,9	5-HT1A	56,62	Serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	helplessness|compound|START_ENTITY helplessness|dep|study study|nmod|END_ENTITY	Serotonin and learned helplessness : a regional study of 5-HT1A , 5-HT2A receptors and the serotonin transport site in rat brain .
11124584	0	Serotonin	0,9	5-HT1A	51,57	Serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|luteinizing luteinizing|dobj|release release|nmod|receptors receptors|nummod|END_ENTITY	Serotonin inhibits luteinizing hormone release via 5-HT1A receptors in the zona incerta of ovariectomised , anaesthetised rats primed with steroids .
11282252	0	Serotonin	0,9	5-HT1A	10,16	Serotonin	5-HT1A	MESH:D012701	3350	Chemical	Gene	potential|nummod|START_ENTITY potential|compound|END_ENTITY	Serotonin 5-HT1A receptor binding potential declines with age as measured by -LSB- 11C -RSB- WAY-100635 and PET .
11723272	0	Serotonin	0,9	5-HT1A	10,16	Serotonin	5-HT1A	MESH:D012701	3350	Chemical	Gene	agonist|amod|START_ENTITY agonist|nummod|END_ENTITY	Serotonin 5-HT1A agonist improves motor complications in rodent and primate parkinsonian models .
12770951	0	Serotonin	0,9	5-HT1A	59,65	Serotonin	5-HT1A	MESH:D012701	15550(Tax:10090)	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|nmod|receptors receptors|nummod|END_ENTITY	Serotonin upregulates the activity of phagocytosis through 5-HT1A receptors .
14519510	0	Serotonin	0,9	5-HT1A	10,16	Serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|nummod|END_ENTITY	Serotonin 5-HT1A receptors might control the output of cortical glutamatergic neurons in rat cingulate cortex .
1511304	0	Serotonin	0,9	5-HT1A	97,103	Serotonin	5-HT1A	MESH:D012701	3350	Chemical	Gene	hyperpolarizes|nsubj|START_ENTITY hyperpolarizes|advcl|activating activating|dobj|receptors receptors|nummod|END_ENTITY	Serotonin preferentially hyperpolarizes capsaicin-sensitive C type sensory neurons by activating 5-HT1A receptors .
20147548	0	Serotonin	0,9	5-HT1A	107,113	Serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|nmod|receptors receptors|compound|END_ENTITY	Serotonin modulates fast-spiking interneuron and synchronous activity in the rat prefrontal cortex through 5-HT1A and 5-HT2A receptors .
24752854	0	Serotonin	0,9	5-HT1A	53,59	Serotonin	5-HT1A	MESH:D012701	3350	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|receptors receptors|compound|END_ENTITY	Serotonin -LRB- 5-HT -RRB- regulates neurite outgrowth through 5-HT1A and 5-HT7 receptors in cultured hippocampal neurons .
25094037	0	Serotonin	0,9	5-HT1A	67,73	Serotonin	5-HT1A	MESH:D012701	3350	Chemical	Gene	control|compound|START_ENTITY control|dep|Focusing Focusing|nmod|role role|nmod|receptors receptors|nummod|END_ENTITY	Serotonin and inhibitory response control : Focusing on the role of 5-HT1A receptors .
25211019	0	Serotonin	6,15	5-HT1A	25,31	Serotonin	5-HT1A	MESH:D012701	3350	Chemical	Gene	Segregates|compound|START_ENTITY Segregates|compound|END_ENTITY	Human Serotonin Receptor 5-HT1A Preferentially Segregates to the Liquid Disordered Phase in Synthetic Lipid Bilayers .
25288485	0	Serotonin	25,34	5-HT1A	18,24	Serotonin	5-HT1A	MESH:D012701	3350	Chemical	Gene	Receptor|compound|START_ENTITY Receptor|nummod|END_ENTITY	Expression of the 5-HT1A Serotonin Receptor in the Hippocampus Is Required for Social Stress Resilience and the Antidepressant-Like Effects Induced by the Nicotinic Partial Agonist Cytisine .
26660328	0	Serotonin	50,59	5-HT1A	60,66	Serotonin	5-HT1A	MESH:D012701	15550(Tax:10090)	Chemical	Gene	Receptors|compound|START_ENTITY Receptors|compound|END_ENTITY	Concentration-Dependent Dual Mode of Zn Action at Serotonin 5-HT1A Receptors : In Vitro and In Vivo Studies .
7472476	0	Serotonin	0,9	5-HT1A	33,39	Serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|inhibition inhibition|nmod|receptors receptors|nummod|END_ENTITY	Serotonin reduces inhibition via 5-HT1A receptors in area CA1 of rat hippocampal slices in vitro .
8101215	0	Serotonin	0,9	5-HT1A	10,16	Serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|nummod|END_ENTITY	Serotonin 5-HT1A receptors mediate inhibition of tyrosine hydroxylation in rat striatum .
8419553	0	Serotonin	0,9	5-HT1A	10,16	Serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	blockade|nummod|START_ENTITY blockade|amod|END_ENTITY	Serotonin 5-HT1A autoreceptor blockade potentiates the ability of the 5-HT reuptake inhibitor citalopram to increase nerve terminal output of 5-HT in vivo : a microdialysis study .
9204940	0	Serotonin	0,9	5-HT1A	10,16	Serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|nummod|END_ENTITY	Serotonin 5-HT1A receptors modulate hippocampal reactivity to afferent stimulation .
9517442	0	Serotonin	0,9	5-HT1A	59,65	Serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|activation activation|nmod|receptors receptors|nummod|END_ENTITY	Serotonin inhibits epileptiform_discharge by activation of 5-HT1A receptors in CA1 pyramidal neurons .
9744926	0	Serotonin	0,9	5-HT1A	46,52	Serotonin	5-HT1A	MESH:D012701	3350	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|inhibition inhibition|nmod|receptors receptors|nummod|END_ENTITY	Serotonin reduces polysynaptic inhibition via 5-HT1A receptors in the superficial entorhinal cortex .
21204459	0	Serotonin	65,74	5-HT1A_Receptor	4,19	Serotonin	5-HT1A Receptor	MESH:D012701	3350	Chemical	Gene	Linked|nmod|START_ENTITY END_ENTITY|dep|Linked	The 5-HT1A_Receptor : A Signaling Hub Linked to Emotional Balance Serotonin or 5-hydroxytryptamine -LRB- 5-HT -RRB- is an ancient chemical that is synthesized in the brain and also in the peripheral system .
10457081	0	Serotonin	0,9	5-HT1B	14,20	Serotonin	5-HT1B	MESH:D012701	25075(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|receptors receptors|compound|END_ENTITY	Serotonin via 5-HT1B and 5-HT2B receptors stimulates anion secretion in the rat epididymal epithelium .
1508839	0	Serotonin	0,9	5-HT1B	105,111	Serotonin	5-HT1B	MESH:D012701	25075(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY treated|nsubj|receptors treated|parataxis|autoreceptor autoreceptor|nsubj|support support|nmod|receptor receptor|nummod|END_ENTITY	Serotonin receptors in the brain of rats treated chronically with imipramine or RU24969 : support for the 5-HT1B receptor being a 5-HT autoreceptor .
23601559	0	Serotonin	0,9	5-HT1B	95,101	Serotonin	5-HT1B	MESH:D012701	3351	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|receptors receptors|nummod|END_ENTITY	Serotonin inhibits apoptosis of pulmonary artery smooth muscle cell by pERK1/2 and PDK through 5-HT1B receptors and 5-HT transporters .
3045568	0	Serotonin	0,9	5-HT1B	65,71	Serotonin	5-HT1B	MESH:D012701	100689321	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|fibroblasts fibroblasts|acl|acting acting|nmod|receptors receptors|nummod|END_ENTITY	Serotonin stimulates DNA synthesis in fibroblasts acting through 5-HT1B receptors coupled to a Gi-protein .
9025111	0	Serotonin	0,9	5-HT1B	115,121	Serotonin	5-HT1B	MESH:D012701	25075(Tax:10116)	Chemical	Gene	efflux|compound|START_ENTITY modulated|nsubjpass|efflux modulated|nmod|autoreceptors autoreceptors|compound|END_ENTITY	Serotonin efflux in the rat ventral lateral geniculate nucleus assessed by fast cyclic voltammetry is modulated by 5-HT1B and 5-HT1D autoreceptors .
9749765	0	Serotonin	0,9	5-HT1B	96,102	Serotonin	5-HT1B	MESH:D012701	25075(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|ccomp|accumbens accumbens|dobj|neurons neurons|nmod|receptors receptors|amod|END_ENTITY	Serotonin inhibits synaptic glutamate currents in rat nucleus accumbens neurons via presynaptic 5-HT1B receptors .
1334504	0	Serotonin	0,9	5-HT1C	65,71	Serotonin	5-HT1C	MESH:D012701	25187(Tax:10116)	Chemical	Gene	agonists|nsubj|START_ENTITY agonists|dobj|levels levels|nmod|activation activation|nmod|receptors receptors|nummod|END_ENTITY	Serotonin agonists increase transferrin levels via activation of 5-HT1C receptors in choroid plexus epithelium .
3022874	0	Serotonin	0,9	5-HT1C	10,16	Serotonin	5-HT1C	MESH:D012701	15560(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|nummod|END_ENTITY	Serotonin 5-HT1C receptors are expressed at high density on choroid_plexus_tumors from transgenic_mice .
7504103	0	Serotonin	0,9	5-HT1C	71,77	Serotonin	5-HT1C	MESH:D012701	3358	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|receptors receptors|amod|activating activating|dep|END_ENTITY	Serotonin inhibits Ca2 + currents in porcine melanotrophs by activating 5-HT1C and 5-HT1A receptors .
2252308	0	Serotonin	0,9	5-HT1D	10,16	Serotonin	5-HT1D	MESH:D012701	3352	Chemical	Gene	START_ENTITY|dobj|receptors receptors|nummod|END_ENTITY	Serotonin 5-HT1D receptors .
3141589	0	Serotonin	0,9	5-HT1D	10,16	Serotonin	5-HT1D	MESH:D012701	3352	Chemical	Gene	receptors|compound|START_ENTITY receptors|nummod|END_ENTITY	Serotonin 5-HT1D receptors in human prefrontal cortex and caudate : interaction with a GTP binding protein .
9519268	0	Serotonin	0,9	5-HT1a	90,96	Serotonin	5-HT1a	MESH:D012701	24473(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|layer layer|nmod|rats rats|nmod|receptors receptors|amod|END_ENTITY	Serotonin regulates synaptic connections in the dentate molecular layer of adult rats via 5-HT1a receptors : evidence for a glial mechanism .
20536936	0	Serotonin	0,9	5-HT1b	87,93	Serotonin	5-HT1b	MESH:D012701	15551(Tax:10090)	Chemical	Gene	controls|nsubj|START_ENTITY controls|nmod|cord cord|nmod|receptors receptors|amod|END_ENTITY	Serotonin controls the maturation of the GABA phenotype in the ventral spinal cord via 5-HT1b receptors .
10216183	0	Serotonin	0,9	5-HT2A	15,21	Serotonin	5-HT2A	MESH:D012701	29595(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|receptors receptors|nummod|END_ENTITY	Serotonin , via 5-HT2A receptors , increases EPSCs in layer V pyramidal cells of prefrontal cortex by an asynchronous mode of glutamate release .
25853073	0	Serotonin	66,75	5-HT2A	86,92	Serotonin	5-HT2A	MESH:D012701	3356	Chemical	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Lack of Association between the Serotonin_Transporter -LRB- 5-HTT -RRB- and Serotonin Receptor -LRB- 5-HT2A -RRB- Gene Polymorphisms with Smoking Behavior among Malaysian Malays .
9016798	0	Serotonin	0,9	5-HT2A	46,52	Serotonin	5-HT2A	MESH:D012701	29595(Tax:10116)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|transport transport|nmod|receptor receptor|nummod|END_ENTITY	Serotonin activates electrolyte transport via 5-HT2A receptor in rat colonic crypt cells .
9268067	0	Serotonin	0,9	5-HT2A	10,16	Serotonin	5-HT2A	MESH:D012701	29595(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|nummod|END_ENTITY	Serotonin 5-HT2A receptors are expressed on pyramidal cells and interneurons in the rat cortex .
17073648	0	Serotonin	0,9	5-HT2C	70,76	Serotonin	5-HT2C	MESH:D012701	3358	Chemical	Gene	involvement|compound|START_ENTITY target|dep|involvement target|nsubj|receptor receptor|amod|END_ENTITY	Serotonin involvement in the basal ganglia pathophysiology : could the 5-HT2C receptor be a new target for therapeutic strategies ?
24244046	0	Serotonin	6,15	5-HT2C	16,22	Serotonin	5-HT2C	MESH:D012701	3358	Chemical	Gene	Model|compound|START_ENTITY Model|compound|END_ENTITY	Human Serotonin 5-HT2C G Protein-Coupled Receptor Homology Model from the b 2 Adrenoceptor Structure : Ligand Docking and Mutagenesis Studies .
25609374	0	Serotonin	7,16	5-HT2C	17,23	Serotonin	5-HT2C	MESH:D012701	3358	Chemical	Gene	Receptors|compound|START_ENTITY Receptors|compound|END_ENTITY	Native Serotonin 5-HT2C Receptors are Expressed as Homodimers on the Apical Surface of Choroid Plexus Epithelial Cells .
8614247	0	Serotonin	0,9	5-HT2_receptor	10,24	Serotonin	5-HT2 receptor	MESH:D012701	3356	Chemical	Gene	availability|amod|START_ENTITY availability|amod|END_ENTITY	Serotonin 5-HT2_receptor availability in chronic cocaine abusers .
9739147	0	Serotonin	0,9	5-HT2c	10,16	Serotonin	5-HT2c	MESH:D012701	25187(Tax:10116)	Chemical	Gene	agonists|amod|START_ENTITY agonists|amod|END_ENTITY	Serotonin 5-HT2c agonists mimic the effect of light pulses on circadian rhythms .
1780417	0	Serotonin	0,9	5-HT3	10,15	Serotonin	5-HT3	MESH:D012701	79246(Tax:10116)	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|nummod|END_ENTITY	Serotonin 5-HT3 antagonists do not alter the discriminative stimulus properties of cocaine .
26701104	0	Serotonin	90,99	5-HT3A	17,23	Serotonin	5-HT3A	MESH:D012701	3359	Chemical	Gene	Activity|compound|START_ENTITY Influence|nmod|Activity Influence|nmod|Polymorphism Polymorphism|nummod|END_ENTITY	Influence of the 5-HT3A Receptor Gene Polymorphism and Childhood Sexual Trauma on Central Serotonin Activity .
10490705	0	Serotonin	0,9	5-HTT	23,28	Serotonin	5-HTT	MESH:D012701	6532	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Serotonin transporter -LRB- 5-HTT -RRB- and gamma-aminobutyric_acid_receptor_subunit_beta3 -LRB- GABRB3 -RRB- gene polymorphisms are not associated with autism in the IMGSA families .
11900612	0	Serotonin	0,9	5-HTT	23,28	Serotonin	5-HTT	MESH:D012701	6532	Chemical	Gene	transporter|nsubj|START_ENTITY transporter|dep|END_ENTITY	Serotonin transporter -LRB- 5-HTT -RRB- gene polymorphisms and susceptibility to cocaine_dependence among African-American individuals .
24093801	0	Serotonin	0,9	5-HTT	23,28	Serotonin	5-HTT	MESH:D012701	6532	Chemical	Gene	polymorphisms|amod|START_ENTITY polymorphisms|appos|END_ENTITY	Serotonin transporter -LRB- 5-HTT -RRB- gene polymorphisms and susceptibility to epilepsy : a meta-analysis and meta-regression .
9514579	0	Serotonin	0,9	5-HTT	23,28	Serotonin	5-HTT	MESH:D012701	6532	Chemical	Gene	transporter|compound|START_ENTITY associated|nsubjpass|transporter associated|dep|END_ENTITY	Serotonin transporter -LRB- 5-HTT -RRB- gene polymorphisms are not associated with susceptibility to mood_disorders .
14573315	0	Serotonin	0,9	5-HTTLPR	37,45	Serotonin	5-HTTLPR	MESH:D012701	6532	Chemical	Gene	promoter|compound|START_ENTITY promoter|appos|END_ENTITY	Serotonin transporter gene promoter -LRB- 5-HTTLPR -RRB- and intron 2 -LRB- VNTR -RRB- polymorphisms in Croatian suicide victims .
17705872	0	Serotonin	32,41	5-HTTLPR	77,85	Serotonin	5-HTTLPR	MESH:D012701	6532	Chemical	Gene	Polymorphism|compound|START_ENTITY Polymorphism|appos|END_ENTITY	Lack of association between the Serotonin Transporter Promoter Polymorphism -LRB- 5-HTTLPR -RRB- and Panic_Disorder : a systematic review and meta-analysis .
17942837	0	Serotonin	0,9	5-HTTLPR	41,49	Serotonin	5-HTTLPR	MESH:D012701	6532	Chemical	Gene	polymorphism|compound|START_ENTITY polymorphism|appos|END_ENTITY	Serotonin transporter gene polymorphism -LRB- 5-HTTLPR -RRB- and anxiety reactivity in daily life : a daily process approach to gene-environment interaction .
18050262	0	Serotonin	0,9	5-HTTLPR	36,44	Serotonin	5-HTTLPR	MESH:D012701	6532	Chemical	Gene	polymorphism|compound|START_ENTITY polymorphism|appos|END_ENTITY	Serotonin transporter polymorphism -LRB- 5-HTTLPR -RRB- association with melancholic_depression : a female specific effect ?
24117502	0	Serotonin	0,9	5-HTTLPR	49,57	Serotonin	5-HTTLPR	MESH:D012701	6532	Chemical	Gene	region|compound|START_ENTITY region|appos|END_ENTITY	Serotonin transporter-linked polymorphic region -LRB- 5-HTTLPR -RRB- genotype and stressful_life_events interact to predict preschool-onset depression : a replication and developmental extension .
25650523	0	Serotonin	0,9	5-HTTLPR	23,31	Serotonin	5-HTTLPR	MESH:D012701	6532	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Serotonin transporter -LRB- 5-HTTLPR -RRB- and norepinephrine_transporter -LRB- NET -RRB- gene polymorphisms : Susceptibility and treatment response of electroconvulsive therapy in treatment_resistant_depression .
26418317	0	Serotonin	29,38	5-HTTLPR	57,65	Serotonin	5-HTTLPR	MESH:D012701	6532	Chemical	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Perceived Parenting Mediates Serotonin Transporter Gene -LRB- 5-HTTLPR -RRB- and Neural System Function during Facial Recognition : A Pilot Study .
26779397	0	Serotonin	0,9	5-HTTLPR	33,41	Serotonin	5-HTTLPR	MESH:D012701	6532	Chemical	Gene	polymorphism|compound|START_ENTITY polymorphism|appos|END_ENTITY	Serotonin promoter polymorphism -LRB- 5-HTTLPR -RRB- predicts biased attention for emotion stimuli : Preliminary evidence of moderation by the social environment .
18309776	0	Serotonin	0,9	5-hT1A_receptor	10,25	Serotonin	5-hT1A receptor	MESH:D012701	3350	Chemical	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Serotonin 5-hT1A_receptor activation prevents phosphorylation of NMDA receptor NR1 subunit in cerebral_ischemia .
25174699	0	Serotonin	0,9	5HT-2A	25,31	Serotonin	5HT-2A	MESH:D012701	3356	Chemical	Gene	Polymorphism|compound|START_ENTITY Polymorphism|appos|END_ENTITY	Serotonin Receptor Gene -LRB- 5HT-2A -RRB- Polymorphism is Associated with Provoked Vestibulodynia and Comorbid Symptoms of Pain .
17504248	0	Serotonin	0,9	5HT1A	25,30	Serotonin	5HT1A	MESH:D012701	3350	Chemical	Gene	receptor|compound|START_ENTITY receptor|dep|genes genes|nummod|END_ENTITY	Serotonin receptor genes 5HT1A and 5HT2A modify the relation between childhood temperament and adulthood hostility .
20079838	0	Serotonin	0,9	ACBP	49,53	Serotonin	ACBP	MESH:D012701	1622	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|appos|END_ENTITY	Serotonin regulates an acyl-CoA-binding_protein -LRB- ACBP -RRB- gene expression in the midgut of Rhodnius prolixus .
21441301	0	Serotonin	0,9	CREB2	54,59	Serotonin	CREB2	MESH:D012701	1386	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Serotonin - and training-induced dynamic regulation of CREB2 in Aplysia .
17003259	0	Serotonin	0,9	GnRH	21,25	Serotonin	GnRH	MESH:D012701	2796	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|amod|END_ENTITY	Serotonin stimulates GnRH secretion through the c-Src-PLC_gamma1 pathway in GT1-7 hypothalamic cells .
26845861	0	Serotonin	46,55	HTR1A	71,76	Serotonin	HTR1A	MESH:D012701	3350	Chemical	Gene	Receptor|compound|START_ENTITY Polymorphisms|nmod|Receptor Analysis|nmod|Polymorphisms Genes|nsubj|Analysis Genes|dobj|END_ENTITY	-LSB- Comparative Analysis of Polymorphisms of the Serotonin Receptor Genes HTR1A , HTR2A , and HTR1B in Hadza and Datoga Males -RSB- .
18076958	0	Serotonin	0,9	HTR1B	23,28	Serotonin	HTR1B	MESH:D012701	317707(Tax:9913)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Serotonin receptor 1B -LRB- HTR1B -RRB- genotype associated with milk production traits in cattle .
25993020	0	Serotonin	0,9	HTR1B	28,33	Serotonin	HTR1B	MESH:D012701	3351	Chemical	Gene	START_ENTITY|dep|Methylation Methylation|appos|END_ENTITY	Serotonin 1B Receptor Gene -LRB- HTR1B -RRB- Methylation as a Risk Factor for Callous-Unemotional_Traits in Antisocial Boys .
21957243	0	Serotonin	0,9	HTR2	15,19	Serotonin	HTR2	MESH:D012701	3356	Chemical	Gene	START_ENTITY|nmod|receptors receptors|nummod|END_ENTITY	Serotonin , via HTR2 receptors , excites neurons in a cortical-like premotor nucleus necessary for song learning and production .
16958038	0	Serotonin	0,9	HTR2A	117,122	Serotonin	HTR2A	MESH:D012701	3356	Chemical	Gene	genes|compound|START_ENTITY genes|dep|hyperactivity_disorder hyperactivity_disorder|dep|transmission transmission|nmod|allele allele|compound|END_ENTITY	Serotonin genes and attention_deficit / hyperactivity_disorder in a Brazilian sample : preferential transmission of the HTR2A 452His allele to affected boys .
18370802	0	Serotonin	0,9	HTR2A	23,28	Serotonin	HTR2A	MESH:D012701	3356	Chemical	Gene	Receptor|compound|START_ENTITY _|nsubj|Receptor _|dep|END_ENTITY	Serotonin Receptor 2A -LRB- HTR2A -RRB- Gene Polymorphisms Are Associated with Blood Pressure , Central Adiposity , _ and_the_Metabolic_Syndrome .
22006095	0	Serotonin	0,9	HTR2A	23,28	Serotonin	HTR2A	MESH:D012701	3356	Chemical	Gene	receptor|compound|START_ENTITY predicts|nsubj|receptor predicts|dep|END_ENTITY	Serotonin receptor 2A -LRB- HTR2A -RRB- gene polymorphism predicts treatment response to venlafaxine_XR in generalized anxiety_disorder .
25658328	0	Serotonin	20,29	HTR2A	43,48	Serotonin	HTR2A	MESH:D012701	3356	Chemical	Gene	2a|compound|START_ENTITY Polymorphism|nmod|2a Polymorphism|appos|END_ENTITY	Polymorphism in the Serotonin Receptor 2a -LRB- HTR2A -RRB- Gene as Possible Predisposal Factor for Aggressive Traits .
26557070	0	Serotonin	0,9	HTR2A	25,30	Serotonin	HTR2A	MESH:D012701	3356	Chemical	Gene	gene|compound|START_ENTITY modulates|nsubj|gene modulates|dep|END_ENTITY	Serotonin receptor gene -LRB- HTR2A -RRB- T102C polymorphism modulates individuals ' perspective taking ability and autistic-like_traits .
15717293	0	Serotonin	0,9	HTR2C	23,28	Serotonin	HTR2C	MESH:D012701	3358	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Serotonin receptor 2C -LRB- HTR2C -RRB- and schizophrenia : examination of possible medication and genetic influences on expression levels .
25549668	0	Serotonin	25,34	Interleukin-6	0,13	Serotonin	Interleukin-6	MESH:D012701	3569	Chemical	Gene	Receptor|compound|START_ENTITY Receptor|compound|END_ENTITY	Interleukin-6 Attenuates Serotonin 2A Receptor Signaling by Activating the JAK-STAT Pathway .
10230710	0	Serotonin	0,9	Lurcher	25,32	Serotonin	Lurcher	MESH:D012701	14804(Tax:10090)	Chemical	Gene	innervation|compound|START_ENTITY innervation|nmod|mice mice|compound|END_ENTITY	Serotonin innervation of Lurcher mutant mice : basic data and manipulation with a combination of amantadine , thiamine and L-tryptophan .
19523439	0	Serotonin	0,9	NOR1	65,69	Serotonin	NOR1	MESH:D012701	18124(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Serotonin 5-HT2C_receptor-independent expression of hypothalamic NOR1 , a novel modulator of food intake and energy balance , in mice .
26247816	0	Serotonin	10,19	Phosphodiesterase-5	45,64	Serotonin	Phosphodiesterase-5	MESH:D012701	8654	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|compound|END_ENTITY	Selective Serotonin Reuptake Inhibitors Plus Phosphodiesterase-5 Inhibitors for Premature Ejaculation : A Systematic Review and Meta-analysis .
23227451	0	Serotonin	10,19	Prolactin	63,72	Serotonin	Prolactin	MESH:D012701	5617	Chemical	Gene	START_ENTITY|dep|Antidepressants Antidepressants|appos|END_ENTITY	Selective Serotonin Reuptake Inhibitor -LRB- SSRI -RRB- Antidepressants , Prolactin and Breast_Cancer .
14622117	0	Serotonin	0,9	SERT	30,34	Serotonin	SERT	MESH:D012701	25553(Tax:10116)	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Serotonin -LRB- 5-HT -RRB- transporter -LRB- SERT -RRB- function after graded destruction of serotonergic neurons .
18209475	0	Serotonin	0,9	SERT	131,135	Serotonin	SERT	MESH:D012701	6532	Chemical	Gene	transport|amod|START_ENTITY modulated|nsubjpass|transport modulated|nmod|Tyr-phosphorylation Tyr-phosphorylation|nmod|END_ENTITY	Serotonin -LRB- 5-HT -RRB- transport in human platelets is modulated by Src-catalysed Tyr-phosphorylation of the plasma membrane transporter SERT .
22176604	0	Serotonin	0,9	SERT	20,24	Serotonin	SERT	MESH:D012701	6532	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|mRNA mRNA|compound|END_ENTITY	Serotonin receptor , SERT mRNA and correlations with symptoms in males with alcohol_dependence and suicide .
26514584	0	Serotonin	27,36	SERT	129,133	Serotonin	SERT	MESH:D012701	15567(Tax:10090)	Chemical	Gene	Inhibition|compound|START_ENTITY Contributions|nmod|Inhibition Contributions|nmod|Mouse Mouse|compound|END_ENTITY	Essential Contributions of Serotonin Transporter Inhibition to the Acute and Chronic Actions of Fluoxetine and Citalopram in the SERT Met172 Mouse .
24917480	0	Serotonin	27,36	SLC6A4	20,26	Serotonin	SLC6A4	MESH:D012701	6532	Chemical	Gene	Region|compound|START_ENTITY Region|compound|END_ENTITY	Association Between SLC6A4 Serotonin Transporter Gene Lainked Polymorphic Region and ADRA2A -1291 C > G and Irritable Bowel Syndrome in Korea .
26674707	0	Serotonin	96,105	SLC6A4	56,62	Serotonin	SLC6A4	MESH:D012701	6532	Chemical	Gene	Associated|nmod|START_ENTITY Associated|nsubj|Polymorphism Polymorphism|nmod|rs3813034 rs3813034|nmod|END_ENTITY	Polymorphism of rs3813034 in Serotonin_Transporter Gene SLC6A4 Is Associated With the Selective Serotonin and Serotonin-Norepinephrine Reuptake Inhibitor Response in Depressive_Disorder : Sequencing Analysis of SLC6A4 .
11573980	0	Serotonin	0,9	VIP	34,37	Serotonin	VIP	MESH:D012701	117064(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	Serotonin modulates expression of VIP and GRP mRNA via the 5-HT -LRB- 1B -RRB- receptor in the suprachiasmatic nucleus of the rat .
7970161	0	Serotonin	0,9	VIP	55,58	Serotonin	VIP	MESH:D012701	117064(Tax:10116)	Chemical	Gene	depletion|compound|START_ENTITY decreases|nsubj|depletion decreases|dobj|mRNA mRNA|compound|END_ENTITY	Serotonin depletion by p-chlorophenylalanine decreases VIP mRNA in the suprachiasmatic nucleus .
20079838	0	Serotonin	0,9	acyl-CoA-binding_protein	23,47	Serotonin	acyl-CoA-binding protein	MESH:D012701	1622	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Serotonin regulates an acyl-CoA-binding_protein -LRB- ACBP -RRB- gene expression in the midgut of Rhodnius prolixus .
21612159	0	Serotonin	0,9	beta-secretase	39,53	Serotonin	beta-secretase	MESH:D012701	23621	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	Serotonin derivatives as inhibitors of beta-secretase -LRB- BACE_1 -RRB- .
17254018	0	Serotonin	0,9	brain-derived_neurotrophic_factor	68,101	Serotonin	brain-derived neurotrophic factor	MESH:D012701	12064(Tax:10090)	Chemical	Gene	function|compound|START_ENTITY dependent|nsubj|function dependent|nmod|END_ENTITY	Serotonin transporter function , but not expression , is dependent on brain-derived_neurotrophic_factor -LRB- BDNF -RRB- : in vivo studies in BDNF-deficient mice .
9535102	0	Serotonin	0,9	corticotropin-releasing_factor	21,51	Serotonin	corticotropin-releasing factor	MESH:D012701	81648(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Serotonin stimulates corticotropin-releasing_factor gene expression in the hypothalamic paraventricular nucleus of conscious rats .
2230952	0	Serotonin	0,9	dopa_decarboxylase	51,69	Serotonin	dopa decarboxylase	MESH:D012701	35190(Tax:7227)	Chemical	Gene	synthesis|compound|START_ENTITY END_ENTITY|nsubj|synthesis	Serotonin synthesis and distribution in Drosophila dopa_decarboxylase genetic mosaics .
7740514	0	Serotonin	0,9	erythropoietin	76,90	Serotonin	erythropoietin	MESH:D012701	24335(Tax:10116)	Chemical	Gene	involved|nsubjpass|START_ENTITY involved|xcomp|developing developing|nmod|treatment treatment|compound|END_ENTITY	Serotonin is involved in the pathogenesis of hypertension developing during erythropoietin treatment in uremic rats .
14988048	0	Serotonin	0,9	glial_cell_line-derived_neurotrophic_factor	20,63	Serotonin	glial cell line-derived neurotrophic factor	MESH:D012701	25453(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|release release|amod|END_ENTITY	Serotonin increases glial_cell_line-derived_neurotrophic_factor release in rat C6 glioblastoma cells .
12480134	0	Serotonin	0,9	glucocorticoid_receptor	32,55	Serotonin	glucocorticoid receptor	MESH:D012701	2908	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Serotonin regulates hippocampal glucocorticoid_receptor expression via a 5-HT7 receptor .
19825906	0	Serotonin	0,9	growth_hormone	53,67	Serotonin	growth hormone	MESH:D012701	2688	Chemical	Gene	function|compound|START_ENTITY blunted|nsubj|function blunted|dobj|response response|amod|END_ENTITY	Serotonin function in pathological gambling : blunted growth_hormone response to sumatriptan .
6206925	0	Serotonin	0,9	growth_hormone	156,170	Serotonin	growth hormone	MESH:D012701	81668(Tax:10116)	Chemical	Gene	content|amod|START_ENTITY content|dep|effect effect|nmod|treatment treatment|amod|END_ENTITY	Serotonin , 5-hydroxyindoleacetic_acid and substance P content of discrete brain nuclei in rats made hypo - or hyperthyroid in the neonatal period : effect of growth_hormone treatment .
3148005	0	Serotonin	0,9	interferon-gamma	88,104	Serotonin	interferon-gamma	MESH:D012701	3458	Chemical	Gene	synthesis|compound|START_ENTITY synthesis|dep|stimulation stimulation|nmod|END_ENTITY	Serotonin and melatonin synthesis in peripheral blood mononuclear cells : stimulation by interferon-gamma as part of an immunomodulatory pathway .
11076827	0	Serotonin	0,9	interleukin-6	20,33	Serotonin	interleukin-6	MESH:D012701	3569	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|synthesis synthesis|amod|END_ENTITY	Serotonin increases interleukin-6 synthesis in human vascular smooth muscle cells .
12673041	0	Serotonin	0,9	interleukin-6	94,107	Serotonin	interleukin-6	MESH:D012701	16193(Tax:10090)	Chemical	Gene	depletion|compound|START_ENTITY enhances|nsubj|depletion enhances|dobj|MK-801-induced MK-801-induced|acl|plasma plasma|dobj|levels levels|amod|END_ENTITY	Serotonin depletion enhances the intracerebroventricularly administered MK-801-induced plasma interleukin-6 levels in mice .
15836614	0	Serotonin	0,9	interleukin-6	119,132	Serotonin	interleukin-6	MESH:D012701	3569	Chemical	Gene	activates|nsubj|START_ENTITY activates|xcomp|resulting resulting|nmod|synthesis synthesis|amod|END_ENTITY	Serotonin via 5-HT7 receptors activates p38 mitogen-activated protein kinase and protein_kinase_C_epsilon resulting in interleukin-6 synthesis in human U373 MG astrocytoma cells .
15992579	0	Serotonin	0,9	interleukin-6	50,63	Serotonin	interleukin-6	MESH:D012701	3569	Chemical	Gene	START_ENTITY|advcl|induction induction|nmod|cells cells|amod|END_ENTITY	Serotonin 5-HT7 receptors coupled to induction of interleukin-6 in human microglial MC-3 cells .
21153080	0	Serotonin	0,9	interleukin-6	20,33	Serotonin	interleukin-6	MESH:D012701	24498(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|release release|amod|END_ENTITY	Serotonin increases interleukin-6 release and decreases tumor_necrosis_factor release from rat adrenal zona glomerulosa cells in vitro .
24211588	0	Serotonin	0,9	interleukin-6	39,52	Serotonin	interleukin-6	MESH:D012701	3569	Chemical	Gene	acts|nsubj|START_ENTITY acts|nmod|regulator regulator|nmod|secretion secretion|amod|END_ENTITY	Serotonin acts as a novel regulator of interleukin-6 secretion in osteocytes through the activation of the 5-HT -LRB- 2B -RRB- _ receptor and the ERK1/2 signalling pathway .
19828014	0	Serotonin	0,9	myeloperoxidase	43,58	Serotonin	myeloperoxidase	MESH:D012701	4353	Chemical	Gene	START_ENTITY|nmod|substrate substrate|nmod|END_ENTITY	Serotonin as a physiological substrate for myeloperoxidase and its superoxide-dependent oxidation to cytotoxic tryptamine-4 ,5 - dione .
17450135	0	Serotonin	0,9	netrin-1	71,79	Serotonin	netrin-1	MESH:D012701	18208(Tax:10090)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	Serotonin modulates the response of embryonic thalamocortical axons to netrin-1 .
15145704	0	Serotonin	0,9	neurokinin_1	38,50	Serotonin	neurokinin 1	MESH:D012701	21333(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Serotonin transporter in substance_P -LRB- neurokinin_1 -RRB- receptor knock-out mice .
2315313	0	Serotonin	0,9	phospholipase_A2	21,37	Serotonin	phospholipase A2	MESH:D012701	151056	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Serotonin stimulates phospholipase_A2 and the release of arachidonic_acid in hippocampal neurons by a type 2 serotonin receptor that is independent of inositolphospholipid hydrolysis .
24177424	0	Serotonin	0,9	pro-opiomelanocortin	26,46	Serotonin	pro-opiomelanocortin	MESH:D012701	18976(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|nmod|neurons neurons|amod|END_ENTITY	Serotonin 2C receptors in pro-opiomelanocortin neurons regulate energy and glucose homeostasis .
15280557	0	Serotonin	0,9	prolactin	41,50	Serotonin	prolactin	MESH:D012701	488241(Tax:9615)	Chemical	Gene	lowering|amod|START_ENTITY lowering|nmod|secretion secretion|compound|END_ENTITY	Serotonin antagonist-induced lowering of prolactin secretion does not affect the pattern of pulsatile secretion of follicle-stimulating hormone and luteinizing hormone in the bitch .
19540238	0	Serotonin	0,9	prolactin	38,47	Serotonin	prolactin	MESH:D012701	100303694(Tax:9103)	Chemical	Gene	subtypes|compound|START_ENTITY influence|nsubj|subtypes influence|dobj|secretion secretion|compound|END_ENTITY	Serotonin receptor subtypes influence prolactin secretion in the turkey .
2144886	0	Serotonin	0,9	prolactin	90,99	Serotonin	prolactin	MESH:D012701	24683(Tax:10116)	Chemical	Gene	inhibition|compound|START_ENTITY reduces|nsubj|inhibition reduces|dobj|secretion secretion|compound|END_ENTITY	Serotonin synthesis inhibition or receptor antagonism reduces pregnancy-induced nocturnal prolactin secretion .
6144226	0	Serotonin	0,9	prolactin	50,59	Serotonin	prolactin	MESH:D012701	5617	Chemical	Gene	affect|nsubj|START_ENTITY affect|dobj|release release|nmod|END_ENTITY	Serotonin and acetylcholine affect the release of prolactin and growth_hormone from pituitary glands of domestic fowl in vitro in the presence of hypothalamic tissue .
6845952	0	Serotonin	0,9	prolactin	21,30	Serotonin	prolactin	MESH:D012701	24683(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|compound|END_ENTITY	Serotonin stimulates prolactin secretion in the hypophysectomized adenohypophyseal grafted rat .
8570767	0	Serotonin	0,9	prolactin	49,58	Serotonin	prolactin	MESH:D012701	5617	Chemical	Gene	function|nsubj|START_ENTITY function|dobj|responses responses|compound|END_ENTITY	Serotonin function in detoxified heroin abusers : prolactin and cortisol responses to fenfluramine challenge .
6779205	0	Serotonin	0,9	protein_I	40,49	Serotonin	protein I	MESH:D012701	56611(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Serotonin stimulates phosphorylation of protein_I in the facial motor nucleus of rat brain .
1674126	0	Serotonin	0,9	somatostatin	99,111	Serotonin	somatostatin	MESH:D012701	24797(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|nmod|END_ENTITY	Serotonin , but neither noradrenaline nor GABA , inhibits capsaicin-evoked release of immunoreactive somatostatin from slices of rat spinal cord .
9225129	0	Serotonin	0,9	thyrotropin-releasing_hormone	28,57	Serotonin	thyrotropin-releasing hormone	MESH:D012701	25569(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|gene gene|amod|END_ENTITY	Serotonin -LRB- 5-HT -RRB- stimulates thyrotropin-releasing_hormone -LRB- TRH -RRB- gene transcription in rat embryonic cardiomyocytes .
2046478	0	Serotonin	0,9	tumor_necrosis_factor-alpha	24,51	Serotonin	tumor necrosis factor-alpha	MESH:D012701	7124	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|synthesis synthesis|amod|END_ENTITY	Serotonin inhibition of tumor_necrosis_factor-alpha synthesis by human monocytes .
17761692	0	SerpinB6	0,8	kallikrein-8	28,40	SerpinB6	kallikrein-8	MESH:C094472	259277(Tax:10090)	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	SerpinB6 is an inhibitor of kallikrein-8 in keratinocytes .
8575321	0	Serrate	0,7	Notch	24,29	Serrate	Notch	null	31293(Tax:7227)	Chemical	Gene	signals|nsubj|START_ENTITY signals|nmod|END_ENTITY	Serrate signals through Notch to establish a Wingless-dependent organizer at the dorsal/ventral compartment boundary of the Drosophila wing .
8600026	0	Serrate	53,60	Notch	70,75	Serrate	Notch	null	31293(Tax:7227)	Chemical	Gene	START_ENTITY|appos|ligand ligand|amod|END_ENTITY	Delta is a ventral to dorsal signal complementary to Serrate , another Notch ligand , in Drosophila wing formation .
11594443	0	Sertindole	0,10	5-HT2c	26,32	Sertindole	5-HT2c	MESH:C066304	25187(Tax:10116)	Chemical	Gene	agonist|nsubj|START_ENTITY agonist|amod|END_ENTITY	Sertindole is a serotonin 5-HT2c inverse agonist and decreases agonist but not antagonist binding to 5-HT2c receptors after chronic treatment .
18239278	0	Sertraline	0,10	P-glycoprotein	124,138	Sertraline	P-glycoprotein	MESH:D020280	5243	Chemical	Gene	have|nsubj|START_ENTITY have|dobj|affinity affinity|nmod|END_ENTITY	Sertraline and its metabolite desmethylsertraline , but not bupropion or its three major metabolites , have high affinity for P-glycoprotein .
9763226	0	Servier_9788	99,111	P-glycoprotein	20,34	Servier 9788	P-glycoprotein	null	5243	Chemical	Gene	resistance|nmod|START_ENTITY resistance|amod|END_ENTITY	S9788 modulation of P-glycoprotein - and Multidrug-related protein-mediated multidrug resistance by Servier_9788 in doxorubicin-resistant MCF7 cells .
1943494	0	Sesamin	0,7	delta_5_desaturase	46,64	Sesamin	delta 5 desaturase	MESH:C054125	84575(Tax:10116)	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Sesamin is a potent and specific inhibitor of delta_5_desaturase in polyunsaturated_fatty_acid biosynthesis .
20306475	0	Sesamin	0,7	intercellular_cell_adhesion_molecule-1	19,57	Sesamin	intercellular cell adhesion molecule-1	MESH:C054125	3383	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|amod|END_ENTITY	Sesamin attenuates intercellular_cell_adhesion_molecule-1 expression in vitro in TNF-alpha-treated human aortic endothelial cells and in vivo in apolipoprotein-E-deficient mice .
11171183	0	Sesamin	0,7	lysophosphatidylcholine_acyltransferase	17,56	Sesamin	lysophosphatidylcholine acyltransferase	MESH:C054125	79888	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Sesamin inhibits lysophosphatidylcholine_acyltransferase in Mortierella alpina .
25117529	0	Sesamin	0,7	macrophage-derived_chemokine	19,47	Sesamin	macrophage-derived chemokine	MESH:C054125	6367	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Sesamin suppresses macrophage-derived_chemokine expression in human monocytes via epigenetic regulation .
20617373	0	Sesamin	0,7	vascular_endothelial_growth_factor	36,70	Sesamin	vascular endothelial growth factor	MESH:C054125	7422	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Sesamin inhibits macrophage-induced vascular_endothelial_growth_factor and matrix_metalloproteinase-9 expression and proangiogenic activity in breast_cancer cells .
24152676	0	Sesquiterpene_lactones	0,22	NF-kB	74,79	Sesquiterpene lactones	NF-kB	CHEBI:37667	81736(Tax:10116)	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|activation activation|compound|END_ENTITY	Sesquiterpene_lactones and their derivatives inhibit high glucose-induced NF-kB activation and MCP-1 and TGF-b1 expression in rat mesangial cells .
26872321	0	Sesquiterpenoids	0,16	PTP1B	22,27	Sesquiterpenoids	PTP1B	CHEBI:26658	5770	Chemical	Gene	START_ENTITY|nmod|Activity Activity|compound|END_ENTITY	Sesquiterpenoids with PTP1B Inhibitory Activity and Cytotoxicity from the Edible Mushroom Pleurotus citrinopileatus .
24095247	0	Setipiprant	0,11	CRTH2	50,55	Setipiprant	CRTH2	null	11251	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|nmod|END_ENTITY	Setipiprant , a selective oral antagonist of human CRTH2 : relative bioavailability of a capsule and a tablet formulation in healthy female and male subjects .
24964348	0	Setipiprant	0,11	CRTH2	25,30	Setipiprant	CRTH2	null	11251	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Setipiprant , a selective CRTH2 antagonist , reduces allergen-induced airway responses in allergic_asthmatics .
18028171	0	Sevelamer_hydrochloride	0,23	parathyroid_hormone	119,138	Sevelamer hydrochloride	parathyroid hormone	MESH:C405346	5741	Chemical	Gene	improves|nsubj|START_ENTITY improves|nmod|levels levels|compound|END_ENTITY	Sevelamer_hydrochloride improves hyperphosphatemia in hemodialysis patients with low_bone_turnover rate and low intact parathyroid_hormone levels .
12357086	0	Sevoflurane	0,11	CA1	76,79	Sevoflurane	CA1	MESH:C009250	310218(Tax:10116)	Chemical	Gene	improves|nsubj|START_ENTITY improves|ccomp|slice slice|dobj|pyramidal_neurons pyramidal_neurons|nummod|END_ENTITY	Sevoflurane improves electrophysiological recovery of rat hippocampal slice CA1 pyramidal_neurons after hypoxia .
9059206	0	Sevoflurane	0,11	CA1	61,64	Sevoflurane	CA1	MESH:C009250	310218(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	Sevoflurane modulates both GABAA and GABAB receptors in area CA1 of rat hippocampus .
23571639	0	Sevoflurane	0,11	Ca2	84,87	Sevoflurane	Ca2	MESH:C009250	12349(Tax:10090)	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|END_ENTITY	Sevoflurane protects ventricular myocytes against oxidative stress-induced cellular Ca2 + overload and hypercontracture .
24870966	0	Sevoflurane	11,22	Hippocalcin	41,52	Sevoflurane	Hippocalcin	MESH:C009250	15444(Tax:10090)	Chemical	Gene	Levels|compound|START_ENTITY Levels|nmod|END_ENTITY	Anesthetic Sevoflurane Reduces Levels of Hippocalcin and Postsynaptic_Density_Protein_95 .
15329596	0	Sevoflurane	0,11	activator_protein-1	55,74	Sevoflurane	activator protein-1	MESH:C009250	3727	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	Sevoflurane inhibits phorbol-myristate-acetate-induced activator_protein-1 activation in human T lymphocytes in vitro : potential role of the p38-stress kinase pathway .
26782552	0	Sevoflurane	0,11	interleukin-6	26,39	Sevoflurane	interleukin-6	MESH:C009250	3569	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|levels levels|amod|END_ENTITY	Sevoflurane downregulates interleukin-6 and interleukin-8 levels in patients after cardiopulmonary bypass surgery : a meta-analysis .
23057425	0	Sevoflurane	0,11	myeloperoxidase	28,43	Sevoflurane	myeloperoxidase	MESH:C009250	100070920(Tax:9796)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|amod|END_ENTITY	Sevoflurane inhibits equine myeloperoxidase release and activity in vitro .
26628963	0	Sevoflurane	0,11	ribosomal_protein_S6	44,64	Sevoflurane	ribosomal protein S6	MESH:C009250	29304(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Sevoflurane inhibits the phosphorylation of ribosomal_protein_S6 in neonatal rat brain .
20423855	0	Shenkangwan	12,23	angiotensin_II	48,62	Shenkangwan	angiotensin II	MESH:C539693	24179(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expressions expressions|nmod|END_ENTITY	-LSB- Effects of Shenkangwan on renal expressions of angiotensin_II and its type I receptor in rats with early diabetic_nephropathy -RSB- .
24447680	0	Shikonin	0,8	HMGB1	60,65	Shikonin	HMGB1	MESH:C016101	15289(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|nmod|END_ENTITY	Shikonin inhibits the lipopolysaccharide-induced release of HMGB1 in RAW264 .7 cells via IFN and NF-kB signaling pathways .
21806999	0	Shikonin	0,8	IL-4	37,41	Shikonin	IL-4	MESH:C016101	16189(Tax:10090)	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|dobj|END_ENTITY	Shikonin inhibited mitogen-activated IL-4 and IL-5 production on EL-4 cells through downregulation of GATA-3 and c-Maf induction .
26650545	0	Shikonin	42,50	TIPE2	0,5	Shikonin	TIPE2	MESH:C016101	79626	Chemical	Gene	Effects|nmod|START_ENTITY Mediates|dobj|Effects Mediates|nsubj|END_ENTITY	TIPE2 Mediates the Suppressive Effects of Shikonin on MMP13 in Osteosarcoma Cells .
24521871	0	Shikonin	0,8	VEGF	34,38	Shikonin	VEGF	MESH:C016101	22339(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Shikonin suppresses IL-17-induced VEGF expression via blockage of JAK2/STAT3 pathway .
24384380	0	Shikonin	0,8	early_growth_response_1	68,91	Shikonin	early growth response 1	MESH:C016101	1958	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Shikonin induces cell cycle arrest in human gastric_cancer -LRB- AGS -RRB- by early_growth_response_1 -LRB- Egr1 -RRB- - mediated p21 gene expression .
14568164	0	Shikonin	0,8	epidermal_growth_factor_receptor	52,84	Shikonin	epidermal growth factor receptor	MESH:C016101	1956	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	Shikonin modulates cell proliferation by inhibiting epidermal_growth_factor_receptor signaling in human epidermoid_carcinoma cells .
25688715	0	Shikonin	0,8	epidermal_growth_factor_receptor	41,73	Shikonin	epidermal growth factor receptor	MESH:C016101	1956	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|END_ENTITY	Shikonin and its derivatives inhibit the epidermal_growth_factor_receptor signaling and synergistically kill glioblastoma cells in combination with erlotinib .
24583460	0	Shikonin	0,8	thioredoxin_reductase	27,48	Shikonin	thioredoxin reductase	MESH:C016101	25824	Chemical	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Shikonin targets cytosolic thioredoxin_reductase to induce ROS-mediated apoptosis in human promyelocytic_leukemia HL-60 cells .
26063410	0	Shogaol	0,7	TRAIL	18,23	Shogaol	TRAIL	MESH:C040115	8743	Chemical	Gene	overcomes|nsubj|START_ENTITY overcomes|dobj|resistance resistance|amod|END_ENTITY	Shogaol overcomes TRAIL resistance in colon_cancer cells via inhibiting of survivin .
16709712	0	Si	34,36	LiF	21,24	Si	LiF	null	3976	Chemical	Gene	study|dep|START_ENTITY study|nmod|END_ENTITY	Comparative study of LiF : Mg , Cu , Na , Si and Li2B4O7 : Cu , Ag , P TL detectors .
25395167	0	SiO2	79,83	Fibrinogen	0,10	SiO2	Fibrinogen	CHEBI:30563	2244	Chemical	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	Fibrinogen enhances the inflammatory response of alveolar_macrophages to TiO2 , SiO2 and carbon nanomaterials .
16124900	0	SiO2	11,15	MMP-9	37,42	SiO2	MMP-9	CHEBI:30563	4318	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of SiO2 on the expression of MMP-9 and TIMP-1 in human alveolar macrophages in vitro -RSB- .
19927649	0	SiO2	11,15	MMP-9	33,38	SiO2	MMP-9	CHEBI:30563	4318	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of SiO2 on expression of MMP-9 / TIMP-1 in human alveolar macrophages in vitro -RSB- .
19927649	0	SiO2	11,15	TIMP-1	39,45	SiO2	TIMP-1	CHEBI:30563	7076	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|END_ENTITY	-LSB- Effect of SiO2 on expression of MMP-9 / TIMP-1 in human alveolar macrophages in vitro -RSB- .
26606595	0	Sialic_Acid	4,15	Hsa	33,36	Sialic Acid	Hsa	MESH:D019158	5018	Chemical	Gene	Protein|compound|START_ENTITY Protein|appos|END_ENTITY	The Sialic_Acid Binding Protein , Hsa , in Streptococcus_gordonii DL1 also Mediates Intergeneric Coaggregation with Veillonella Species .
27065798	0	Sialic_Acid	0,11	MAG	59,62	Sialic Acid	MAG	MESH:D019158	4099	Chemical	Gene	Required|nsubjpass|START_ENTITY Required|nmod|END_ENTITY	Sialic_Acid Is Required for Neuronal Inhibition by Soluble MAG but not for Membrane Bound MAG .
19855092	0	Sialic_acid	0,11	adiponectin	28,39	Sialic acid	adiponectin	MESH:D019158	9370	Chemical	Gene	modification|amod|START_ENTITY modification|nmod|END_ENTITY	Sialic_acid modification of adiponectin is not required for multimerization or secretion but determines half-life in circulation .
10741468	0	Sialic_acid	0,11	agrin	21,26	Sialic acid	agrin	MESH:D019158	375790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Sialic_acid inhibits agrin signaling in C2 myotubes .
19138682	0	Sialic_acid	0,11	apolipoprotein_E	22,38	Sialic acid	apolipoprotein E	MESH:D019158	348	Chemical	Gene	moiety|amod|START_ENTITY moiety|nmod|END_ENTITY	Sialic_acid moiety of apolipoprotein_E and its impact on the formation of lipoprotein particles in human cerebrospinal fluid .
18023277	0	Sialic_acid	0,11	apolipoprotein_E3	22,39	Sialic acid	apolipoprotein E3	MESH:D019158	348	Chemical	Gene	moiety|amod|START_ENTITY moiety|nmod|END_ENTITY	Sialic_acid moiety of apolipoprotein_E3 at Thr -LRB- 194 -RRB- affects its interaction with beta-amyloid -LRB- 1-42 -RRB- peptides .
8995428	0	Sialic_acid	0,11	myelin-associated_glycoprotein	27,57	Sialic acid	myelin-associated glycoprotein	MESH:D019158	103161439	Chemical	Gene	specificity|amod|START_ENTITY specificity|nmod|END_ENTITY	Sialic_acid specificity of myelin-associated_glycoprotein binding .
27045038	0	Sialostatin_L2	17,31	Annexin_A2	41,51	Sialostatin L2	Annexin A2	null	302	Chemical	Gene	Binds|nsubj|START_ENTITY Binds|nmod|END_ENTITY	The Tick Protein Sialostatin_L2 Binds to Annexin_A2 and Inhibits NLRC4-Mediated Inflammasome Activation .
20720348	0	Sibutramine	0,11	insulin	61,68	Sibutramine	insulin	MESH:C058254	3630	Chemical	Gene	compared|nsubj|START_ENTITY compared|xcomp|sibutramine sibutramine|nmod|resistance resistance|compound|END_ENTITY	Sibutramine and L-carnitine compared to sibutramine alone on insulin resistance in diabetic patients .
16380708	0	Sibutramine	0,11	neuropeptide_Y	54,68	Sibutramine	neuropeptide Y	MESH:C058254	4852	Chemical	Gene	therapy|amod|START_ENTITY therapy|dep|effects effects|nmod|END_ENTITY	Sibutramine therapy in obese women -- effects on plasma neuropeptide_Y -LRB- NPY -RRB- , insulin , leptin and beta-endorphin concentrations .
16018669	0	Silanediol	0,10	angiotensin-converting_enzyme	25,54	Silanediol	angiotensin-converting enzyme	MESH:C475536	1636	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Silanediol inhibitors of angiotensin-converting_enzyme .
26716643	0	Sildenafil	0,10	CD95	95,99	Sildenafil	CD95	MESH:C101426	355	Chemical	Gene	sensitizes|nsubj|START_ENTITY sensitizes|nmod|END_ENTITY	Sildenafil -LRB- Viagra -RRB- sensitizes prostate_cancer cells to doxorubicin-mediated apoptosis through CD95 .
26580240	0	Sildenafil	15,25	Insulin	35,42	Sildenafil	Insulin	MESH:C101426	3630	Chemical	Gene	Sensitivity|compound|START_ENTITY Sensitivity|compound|END_ENTITY	Treatment with Sildenafil Improves Insulin Sensitivity in Prediabetes : A Randomized , Controlled Trial .
24261938	0	Sildenafil	0,10	PDE-5	51,56	Sildenafil	PDE-5	MESH:C101426	8654	Chemical	Gene	phosphodiesterase_type_5|amod|START_ENTITY phosphodiesterase_type_5|appos|END_ENTITY	Sildenafil and analogous phosphodiesterase_type_5 -LRB- PDE-5 -RRB- inhibitors in herbal food supplements sampled on the Dutch market .
16716091	0	Sildenafil	0,10	PDE5	14,18	Sildenafil	PDE5	MESH:C101426	8654	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Sildenafil , a PDE5 inhibitor , in the treatment of pulmonary_hypertension .
12946946	0	Sildenafil	0,10	RhoA	30,34	Sildenafil	RhoA	MESH:C101426	117273(Tax:10116)	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|nmod|expression expression|compound|END_ENTITY	Sildenafil prevents change in RhoA expression induced by chronic_hypoxia in rat pulmonary artery .
21851826	0	Sildenafil	0,10	cyclin_A	48,56	Sildenafil	cyclin A	MESH:C101426	890	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Sildenafil inhibits calcineurin/NFATc2-mediated cyclin_A expression in pulmonary artery smooth muscle cells .
11959087	0	Sildenafil	0,10	phosphodiesterase_type_5	23,47	Sildenafil	phosphodiesterase type 5	MESH:C101426	171115(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitors inhibitors|amod|END_ENTITY	Sildenafil and T-1032 , phosphodiesterase_type_5 inhibitors , showed a different vasorelaxant property in the isolated rat aorta .
21133896	0	Sildenafil	0,10	phosphodiesterase_type_5	14,38	Sildenafil	phosphodiesterase type 5	MESH:C101426	171115(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Sildenafil , a phosphodiesterase_type_5 inhibitor , attenuates diabetic_nephropathy in non-insulin-dependent Otsuka Long-Evans Tokushima Fatty rats .
21333692	0	Sildenafil	0,10	phosphodiesterase_type_5	24,48	Sildenafil	phosphodiesterase type 5	MESH:C101426	242202(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Sildenafil , a selective phosphodiesterase_type_5 inhibitor , enhances memory reconsolidation of an inhibitory avoidance task in mice .
26295204	0	Sildenafil	0,10	phosphodiesterase_type_5	14,38	Sildenafil	phosphodiesterase type 5	MESH:C101426	171115(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Sildenafil , a phosphodiesterase_type_5 inhibitor , attenuates diabetic_nephropathy in STZ-induced diabetic rats .
16716755	0	Sildenafil	0,10	thioredoxin	112,123	Sildenafil	thioredoxin	MESH:C101426	7295	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|expression expression|nmod|END_ENTITY	Sildenafil induces angiogenic response in human coronary arteriolar endothelial cells through the expression of thioredoxin , hemeoxygenase and vascular_endothelial_growth_factor .
18037755	0	Sildenafil_citrate	0,18	atrial_natriuretic_peptide	55,81	Sildenafil citrate	atrial natriuretic peptide	MESH:C101426	608289(Tax:9615)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Sildenafil_citrate -LRB- Viagra -RRB- enhances vasodilatation by atrial_natriuretic_peptide in normal dogs .
11289569	0	Sildenafil_citrate	0,18	phosphodiesterase_type_5	32,56	Sildenafil citrate	phosphodiesterase type 5	MESH:C101426	8654	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Sildenafil_citrate , a selective phosphodiesterase_type_5 inhibitor : urologic and cardiovascular implications .
25197339	0	Sildenefil	0,10	connexin_40	21,32	Sildenefil	connexin 40	null	50563(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Sildenefil increases connexin_40 in smooth muscle cells through activation of BMP pathways in pulmonary_arterial_hypertension .
19966941	0	Silibinin	0,9	CD44	21,25	Silibinin	CD44	MESH:C440975	960	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|nummod|END_ENTITY	Silibinin suppresses CD44 expression in prostate_cancer cells .
22110198	0	Silibinin	0,9	CD44	41,45	Silibinin	CD44	MESH:C440975	960	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Silibinin suppresses EGFR ligand-induced CD44 expression through inhibition of EGFR activity in breast_cancer cells .
22110198	0	Silibinin	0,9	EGFR	21,25	Silibinin	EGFR	MESH:C440975	1956	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Silibinin suppresses EGFR ligand-induced CD44 expression through inhibition of EGFR activity in breast_cancer cells .
22110198	0	Silibinin	0,9	EGFR	79,83	Silibinin	EGFR	MESH:C440975	1956	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|inhibition inhibition|nmod|activity activity|amod|END_ENTITY	Silibinin suppresses EGFR ligand-induced CD44 expression through inhibition of EGFR activity in breast_cancer cells .
19778521	0	Silibinin	0,9	HIF-1alpha	33,43	Silibinin	HIF-1alpha	MESH:C440975	3091	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Silibinin inhibits expression of HIF-1alpha through suppression of protein translation in prostate_cancer cells .
25032222	0	Silibinin	0,9	ICAM-1	19,25	Silibinin	ICAM-1	MESH:C440975	3383	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Silibinin inhibits ICAM-1 expression via regulation of N-linked and O-linked glycosylation in ARPE-19 cells .
17214970	0	Silibinin	0,9	MMP-9	33,38	Silibinin	MMP-9	MESH:C440975	4318	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Silibinin suppresses PMA-induced MMP-9 expression by blocking the AP-1 activation via MAPK signaling pathways in MCF-7 human breast_carcinoma cells .
19181503	0	Silibinin	0,9	MMP-9	31,36	Silibinin	MMP-9	MESH:C440975	4318	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|dobj|expression expression|compound|END_ENTITY	Silibinin prevents TPA-induced MMP-9 expression and VEGF secretion by inactivation of the Raf/MEK/ERK pathway in MCF-7 human breast_cancer cells .
19715751	0	Silibinin	0,9	MMP-9	31,36	Silibinin	MMP-9	MESH:C440975	4318	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|dobj|expression expression|compound|END_ENTITY	Silibinin prevents TPA-induced MMP-9 expression by down-regulation of COX-2 in human breast_cancer cells .
23115104	0	Silibinin	0,9	NFATc1	92,98	Silibinin	NFATc1	MESH:C440975	18018(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	Silibinin inhibits prostate_cancer cells - and RANKL-induced osteoclastogenesis by targeting NFATc1 , NF-kB , and AP-1 activation in RAW264 .7 cells .
17341659	0	Silibinin	0,9	Stat3	46,51	Silibinin	Stat3	MESH:C440975	6774	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	Silibinin inhibits constitutive activation of Stat3 , and causes caspase activation and apoptotic death of human prostate_carcinoma DU145 cells .
23004355	0	Silibinin	0,9	VEGF	19,23	Silibinin	VEGF	MESH:C440975	83785(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|compound|END_ENTITY	Silibinin inhibits VEGF secretion and age-related_macular_degeneration in a hypoxia-dependent manner through the PI-3 kinase/Akt/mTOR pathway .
25771396	0	Silibinin	0,9	acetylcholinesterase	19,39	Silibinin	acetylcholinesterase	MESH:C440975	11423(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Silibinin inhibits acetylcholinesterase activity and amyloid b peptide aggregation : a dual-target drug for the treatment of Alzheimer 's _ disease .
11059749	0	Silibinin	0,9	insulin-like_growth_factor-binding_protein_3	23,67	Silibinin	insulin-like growth factor-binding protein 3	MESH:C440975	3486	Chemical	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|amod|END_ENTITY	Silibinin up-regulates insulin-like_growth_factor-binding_protein_3 expression and inhibits proliferation of androgen-independent prostate_cancer cells .
24244809	0	Silibinin	0,9	p38_MAPK	65,73	Silibinin	p38 MAPK	MESH:C440975	26416(Tax:10090)	Chemical	Gene	Activation|compound|START_ENTITY Activation|nmod|END_ENTITY	Silibinin Inhibits LPS-Induced Macrophage Activation by Blocking p38_MAPK in RAW 264.7 Cells .
15792956	0	Silibinin	0,9	p53	52,55	Silibinin	p53	MESH:C440975	22060(Tax:10090)	Chemical	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|activation activation|compound|END_ENTITY	Silibinin up-regulates DNA-protein kinase-dependent p53 activation to enhance UVB-induced apoptosis in mouse epithelial JB6 cells .
21212516	0	Silibinin	0,9	p53	20,23	Silibinin	p53	MESH:C440975	7157	Chemical	Gene	activated|nsubj|START_ENTITY activated|dobj|END_ENTITY	Silibinin activated p53 and induced autophagic_death in human fibrosarcoma HT1080 cells via reactive_oxygen_species-p38 and c-Jun_N-terminal_kinase pathways .
25750273	0	Silibinin	14,23	p53	79,82	Silibinin	p53	MESH:C440975	7157	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	The Effect of Silibinin in Enhancing Toxicity of Temozolomide and Etoposide in p53 and PTEN-mutated Resistant Glioma Cell Lines .
10377442	0	Silibinin	0,9	prostate-specific_antigen	20,45	Silibinin	prostate-specific antigen	MESH:C440975	354	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|END_ENTITY	Silibinin decreases prostate-specific_antigen with cell growth inhibition via G1 arrest , leading to differentiation of prostate_carcinoma cells : implications for prostate_cancer intervention .
20941752	0	Silica	0,6	AP-1	48,52	Silica	AP-1	MESH:D012822	3727	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|pathway pathway|compound|END_ENTITY	Silica induces cell cycle changes through PI-3K / AP-1 pathway in human embryo lung fibroblast cells .
26263183	0	Silica	51,57	Caspase-3	38,47	Silica	Caspase-3	MESH:D012822	836	Chemical	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	miR-98 and its host gene Huwe1 target Caspase-3 in Silica nanoparticles-treated male germ cells .
26556331	0	Silica	38,44	Cyclooxygenase-2	18,34	Silica	Cyclooxygenase-2	MESH:D012822	5743	Chemical	Gene	Microspheres|compound|START_ENTITY END_ENTITY|nmod|Microspheres	Immobilization of Cyclooxygenase-2 on Silica Gel Microspheres : Optimization and Characterization .
11076697	0	Silica	0,6	I_kappa_B-alpha	85,100	Silica	I kappa B-alpha	MESH:D012822	4792	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Silica induces nuclear factor-kappa B activation through tyrosine phosphorylation of I_kappa_B-alpha in RAW264 .7 macrophages .
20941752	0	Silica	0,6	PI-3K	42,47	Silica	PI-3K	MESH:D012822	5293	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|pathway pathway|compound|END_ENTITY	Silica induces cell cycle changes through PI-3K / AP-1 pathway in human embryo lung fibroblast cells .
20020854	0	Silica	0,6	Plasminogen_Activator_Inhibitor-1	15,48	Silica	Plasminogen Activator Inhibitor-1	MESH:D012822	5054	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Silica Induces Plasminogen_Activator_Inhibitor-1 Expression through a MAPKs/AP -1 - Dependent Mechanism in Human Lung Epithelial Cells .
23290651	0	Silica	1,7	a-SMA	16,21	Silica	a-SMA	MESH:D012822	58	Chemical	Gene	induced|nsubj|START_ENTITY induced|dobj|expression expression|amod|END_ENTITY	-LSB- Silica induced a-SMA expression in HBE cell line by targeting the PI3K/Akt pathway -RSB- .
16050801	0	Silica	0,6	cyclooxygenase-2	21,37	Silica	cyclooxygenase-2	MESH:D012822	5743	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Silica induces human cyclooxygenase-2 gene expression through the NF-kappaB signaling pathway .
12943543	0	Silica	0,6	proline-rich_protein	41,61	Silica	proline-rich protein	MESH:D012822	101210961	Chemical	Gene	deposition|nsubj|START_ENTITY deposition|nmod|END_ENTITY	Silica deposition by a strongly cationic proline-rich_protein from systemically resistant cucumber plants .
7882909	0	Silica	0,6	tumor_necrosis_factor	17,38	Silica	tumor necrosis factor	MESH:D012822	7124	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|production production|amod|END_ENTITY	Silica increases tumor_necrosis_factor -LRB- TNF -RRB- production , in part , by upregulating the TNF promoter .
26662621	0	Silicon	20,27	CO2	47,50	Silicon	CO2	MESH:D012825	717	Chemical	Gene	Nanoparticles|compound|START_ENTITY Nanoparticles|nmod|END_ENTITY	Graphene Coating of Silicon Nanoparticles with CO2 - Enhanced Chemical Vapor Deposition .
25230499	0	Silitidil	10,19	prolactin	74,83	Silitidil	prolactin	null	24683(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|compound|END_ENTITY	Effect of Silitidil , a standardized extract of milk thistle , on the serum prolactin levels in female rats .
26308715	0	Silodosin	10,19	Alpha1A-Adrenoceptor	24,44	Silodosin	Alpha1A-Adrenoceptor	MESH:C095285	29412(Tax:10116)	Chemical	Gene	START_ENTITY|appos|Antagonist Antagonist|compound|END_ENTITY	Effect of Silodosin , an Alpha1A-Adrenoceptor Antagonist , on Ventral_Prostatic_Hyperplasia in the Spontaneously Hypertensive Rat .
22924980	0	Silodosin	0,9	alpha-1	36,43	Silodosin	alpha-1	MESH:C095285	146	Chemical	Gene	START_ENTITY|dep|antagonist antagonist|amod|END_ENTITY	Silodosin : a new subtype selective alpha-1 antagonist for the treatment of lower urinary tract symptoms in patients with benign_prostatic_hyperplasia .
20109995	0	Silodosin	0,9	alpha1A-adrenergic_receptor	23,50	Silodosin	alpha1A-adrenergic receptor	MESH:C095285	146	Chemical	Gene	START_ENTITY|dep|antagonist antagonist|amod|END_ENTITY	Silodosin : a selective alpha1A-adrenergic_receptor antagonist for the treatment of benign_prostatic_hyperplasia .
18042003	0	Silodosin	0,9	alpha_1A-adrenoceptor	29,50	Silodosin	alpha 1A-adrenoceptor	MESH:C095285	148	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Silodosin , a novel selective alpha_1A-adrenoceptor selective antagonist for the treatment of benign_prostatic_hyperplasia .
26353595	0	Silver	15,21	Triosephosphate_Isomerase	41,66	Silver	Triosephosphate Isomerase	MESH:D012834	7167	Chemical	Gene	Nanoparticles|compound|START_ENTITY Nanoparticles|nmod|END_ENTITY	Interaction of Silver Nanoparticles with Triosephosphate_Isomerase from Human and Malarial Parasite -LRB- Plasmodium_falciparum -RRB- : A Comparative Study .
16528449	0	Silybin	0,7	cytochrome_P450_1A1	35,54	Silybin	cytochrome P450 1A1	MESH:C440975	1543	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|activity activity|amod|END_ENTITY	Silybin and dehydrosilybin inhibit cytochrome_P450_1A1 catalytic activity : a study in human keratinocytes and human hepatoma cells .
26910310	0	Silychristin	0,12	MCT8	118,122	Silychristin	MCT8	MESH:C015504	6567	Chemical	Gene	Inhibitor|nsubj|START_ENTITY Inhibitor|nmod|END_ENTITY	Silychristin , a Flavonolignan Derived From the Milk Thistle , Is a Potent Inhibitor of the Thyroid Hormone Transporter MCT8 .
26729088	0	Silymarin	0,9	ABCA1	31,36	Silymarin	ABCA1	MESH:D012838	19	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Silymarin Constituents Enhance ABCA1 Expression in THP-1 Macrophages .
15713892	0	Silymarin	0,9	Bax	86,89	Silymarin	Bax	MESH:D012838	12028(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|pathway pathway|nmod|END_ENTITY	Silymarin induces apoptosis primarily through a p53-dependent pathway involving Bcl-2 / Bax , cytochrome c release , and caspase activation .
18373278	0	Silymarin	0,9	COX-2	24,29	Silymarin	COX-2	MESH:D012838	29527(Tax:10116)	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|compound|END_ENTITY	Silymarin downregulates COX-2 expression and attenuates_hyperlipidemia during NDEA-induced rat hepatocellular_carcinoma .
24176839	0	Silymarin	10,19	Pdx-1	23,28	Silymarin	Pdx-1	MESH:D012838	29535(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effect of Silymarin in Pdx-1 expression and the proliferation of pancreatic b-cells in a pancreatectomy model .
26729088	0	Silymarin	0,9	THP-1	51,56	Silymarin	THP-1	MESH:D012838	2736	Chemical	Gene	Expression|compound|START_ENTITY Expression|nmod|Macrophages Macrophages|compound|END_ENTITY	Silymarin Constituents Enhance ABCA1 Expression in THP-1 Macrophages .
24790514	0	Silymarin	14,23	VEGF	27,31	Silymarin	VEGF	MESH:D012838	7422	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|levels levels|amod|END_ENTITY	The effect of Silymarin on VEGF , VEGFR-1 and IL-1a levels in placental cultures of severe preeclamptic women .
21829575	0	Silymarin	0,9	b-catenin	18,27	Silymarin	b-catenin	MESH:D012838	1499	Chemical	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Silymarin targets b-catenin signaling in blocking migration/invasion of human melanoma cells .
25479723	0	Silymarin	0,9	cyclin_D1	18,27	Silymarin	cyclin D1	MESH:D012838	595	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|degradation degradation|amod|END_ENTITY	Silymarin induces cyclin_D1 proteasomal degradation via its phosphorylation of threonine-286 in human colorectal_cancer cells .
22445624	0	Silymarin	0,9	cytochrome_P450_3A2	24,43	Silymarin	cytochrome P450 3A2	MESH:D012838	266682(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Silymarin regulates the cytochrome_P450_3A2 and glutathione_peroxides in the liver of streptozotocin-induced diabetic rats .
15728908	0	Simocyclinone_D8	0,16	DNA_gyrase	34,44	Simocyclinone D8	DNA gyrase	MESH:C416814	7153	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Simocyclinone_D8 , an inhibitor of DNA_gyrase with a novel mode of action .
12438947	0	Simvastatin	0,11	AKT	70,73	Simvastatin	AKT	MESH:D019821	207	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|nmod|END_ENTITY	Simvastatin induces activation of the serine-threonine protein kinase AKT and increases survival of isolated human_pancreatic_islets .
17878758	0	Simvastatin	0,11	Angiotensin_II	65,79	Simvastatin	Angiotensin II	MESH:D019821	24179(Tax:10116)	Chemical	Gene	reverses|nsubj|START_ENTITY reverses|dobj|damage damage|nmod|hypertension hypertension|compound|END_ENTITY	Simvastatin reverses target organ damage and oxidative stress in Angiotensin_II hypertension : comparison with apocynin , tempol , and hydralazine .
18628692	0	Simvastatin	0,11	BMP-2	93,98	Simvastatin	BMP-2	MESH:D019821	29373(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|pathway pathway|compound|END_ENTITY	Simvastatin stimulates chondrogenic phenotype of intervertebral disc cells partially through BMP-2 pathway .
17241114	0	Simvastatin	0,11	Bcl-2	64,69	Simvastatin	Bcl-2	MESH:D019821	596	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|mRNA mRNA|amod|cytotoxicity cytotoxicity|nmod|END_ENTITY	Simvastatin protects neurons from cytotoxicity by up-regulating Bcl-2 mRNA and protein .
21777583	0	Simvastatin	0,11	Bcl-2	24,29	Simvastatin	Bcl-2	MESH:D019821	24224(Tax:10116)	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	Simvastatin upregulates Bcl-2 expression and protects retinal neurons from early ischemia/reperfusion injury in the rat retina .
25548604	0	Simvastatin	0,11	Bcl-2	109,114	Simvastatin	Bcl-2	MESH:D019821	596	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|apoptosis apoptosis|nmod|cells cells|acl|induced induced|advcl|upregulating upregulating|dobj|expression expression|nmod|END_ENTITY	Simvastatin inhibits apoptosis of endothelial cells induced by sepsis through upregulating the expression of Bcl-2 and downregulating Bax .
26280117	0	Simvastatin	119,130	C-Reactive_Protein	18,36	Simvastatin	C-Reactive Protein	MESH:D019821	1401	Chemical	Gene	Data|dep|START_ENTITY END_ENTITY|parataxis|Data	Elevated Baseline C-Reactive_Protein as a Predictor of Outcome After Aneurysmal_Subarachnoid_Hemorrhage : Data From the Simvastatin in Aneurysmal_Subarachnoid_Hemorrhage -LRB- STASH -RRB- Trial .
26280117	0	Simvastatin	119,130	C-Reactive_Protein	18,36	Simvastatin	C-Reactive Protein	MESH:D019821	1401	Chemical	Gene	Data|dep|START_ENTITY END_ENTITY|parataxis|Data	Elevated Baseline C-Reactive_Protein as a Predictor of Outcome After Aneurysmal_Subarachnoid_Hemorrhage : Data From the Simvastatin in Aneurysmal_Subarachnoid_Hemorrhage -LRB- STASH -RRB- Trial .
12826933	0	Simvastatin	0,11	C-reactive_protein	76,94	Simvastatin	C-reactive protein	MESH:D019821	1401	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|monocytes monocytes|acl|stimulated stimulated|nmod|END_ENTITY	Simvastatin inhibits interleukin-6 release in human monocytes stimulated by C-reactive_protein and lipopolysaccharide .
22902096	0	Simvastatin	0,11	C-reactive_protein	153,171	Simvastatin	C-reactive protein	MESH:D019821	1401	Chemical	Gene	decreases|amod|START_ENTITY plasma|nsubj|decreases plasma|parataxis|relevance relevance|nmod|profile profile|amod|END_ENTITY	Simvastatin but not bezafibrate decreases plasma lipoprotein-associated phospholipase A mass in type 2 diabetes_mellitus : relevance of high sensitive C-reactive_protein , lipoprotein profile and low-density lipoprotein -LRB- LDL -RRB- electronegativity .
18269829	0	Simvastatin	1,12	CD40L	27,32	Simvastatin	CD40L	MESH:D019821	959	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	-LSB- Simvastatin downregulates CD40L induced vascular_cell_adhesion_molecule-1 expression and adhesive function in human umbilical vein endothelial cells -RSB- .
20191585	0	Simvastatin	0,11	Cyr61	41,46	Simvastatin	Cyr61	MESH:D019821	3491	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Simvastatin inhibits cytokine-stimulated Cyr61 expression in osteoblastic cells : a therapeutic benefit for arthritis .
23611379	0	Simvastatin	0,11	Cyr61	50,55	Simvastatin	Cyr61	MESH:D019821	83476(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|nmod|END_ENTITY	Simvastatin suppresses osteoblastic expression of Cyr61 and progression of apical_periodontitis through enhancement of the transcription factor Forkhead/winged helix box protein O3a .
23072789	0	Simvastatin	0,11	ERK1/2	48,54	Simvastatin	ERK1/2	MESH:D019821	50689;116590	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	Simvastatin inhibits the additive activation of ERK1/2 and proliferation of rat vascular smooth muscle cells induced by combined mechanical stress and oxLDL through LOX-1 pathway .
23239110	0	Simvastatin	0,11	FoxO3a	138,144	Simvastatin	FoxO3a	MESH:D019821	294515(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|regulation regulation|nmod|END_ENTITY	Simvastatin inhibits cysteine-rich_protein_61 expression in rheumatoid_arthritis synovial fibroblasts through the regulation of sirtuin-1 / FoxO3a signaling .
23581225	0	Simvastatin	0,11	HER2	26,30	Simvastatin	HER2	MESH:D019821	2064	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	Simvastatin downregulates HER2 via upregulation of PEA3 to induce cell death in HER2-positive breast_cancer cells .
19409105	9	Simvastatin	1270,1281	HO-1	1306,1310	Simvastatin	HO-1	MESH:D019821	24451(Tax:10116)	Chemical	Gene	increased|nsubj|START_ENTITY increased|dobj|expression expression|compound|END_ENTITY	Simvastatin significantly increased HO-1 protein expression and HO activity in the lungs of rats with PH ; however co-administration of SnPP reduced HO-1 activity only .
21856936	0	Simvastatin	0,11	IFN_regulatory_factor_4	21,44	Simvastatin	IFN regulatory factor 4	MESH:D019821	3662	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Simvastatin inhibits IFN_regulatory_factor_4 expression and Th17 cell differentiation in CD4 + T cells derived from patients with multiple_sclerosis .
18453621	0	Simvastatin	0,11	IL-17	21,26	Simvastatin	IL-17	MESH:D019821	3605	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|compound|END_ENTITY	Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4 + lymphocytes .
22915623	0	Simvastatin	0,11	IL-17	72,77	Simvastatin	IL-17	MESH:D019821	3605	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|effects effects|nmod|END_ENTITY	Simvastatin inhibits the pro-inflammatory and pro-thrombotic effects of IL-17 and TNF-a on endothelial cells .
26043025	0	Simvastatin	0,11	IL-17	30,35	Simvastatin	IL-17	MESH:D019821	3605	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	Simvastatin suppresses airway IL-17 and upregulates IL-10 in patients with stable COPD .
16511915	0	Simvastatin	0,11	IL-6	50,54	Simvastatin	IL-6	MESH:D019821	3569	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|nmod|interleukin_6 interleukin_6|appos|END_ENTITY	Simvastatin inhibits production of interleukin_6 -LRB- IL-6 -RRB- and IL-8 and cell proliferation induced by tumor_necrosis_factor-alpha in fibroblast-like_synoviocytes from patients with rheumatoid_arthritis .
25626487	0	Simvastatin	75,86	LDL-C	90,95	Simvastatin	LDL-C	MESH:D019821	22796	Chemical	Gene	START_ENTITY|nmod|Levels Levels|compound|END_ENTITY	Impact of Switching From High-Efficacy Lipid-Lowering Therapies to Generic Simvastatin on LDL-C Levels and LDL-C Goal Attainment Among High-Risk Primary and Secondary Prevention Populations in the United Kingdom .
11902809	0	Simvastatin	0,11	MDR1	63,67	Simvastatin	MDR1	MESH:D019821	5243	Chemical	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	Simvastatin and lovastatin , but not pravastatin , interact with MDR1 .
18625914	0	Simvastatin	0,11	MMP-1	35,40	Simvastatin	MMP-1	MESH:D019821	4312	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Simvastatin suppresses LPS-induced MMP-1 expression in U937 mononuclear cells by inhibiting protein isoprenylation-mediated ERK activation .
15728660	0	Simvastatin	0,11	MMP-9	21,26	Simvastatin	MMP-9	MESH:D019821	4318	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|compound|END_ENTITY	Simvastatin inhibits MMP-9 secretion from human saphenous vein smooth muscle cells by inhibiting the RhoA/ROCK pathway and reducing MMP-9 mRNA levels .
17184595	0	Simvastatin	0,11	MMP-9	48,53	Simvastatin	MMP-9	MESH:D019821	4318	Chemical	Gene	prevent|nsubj|START_ENTITY prevent|dobj|increase increase|nmod|ratio ratio|compound|END_ENTITY	Simvastatin could prevent increase of the serum MMP-9 / TIMP-1 ratio in acute ischaemic_stroke .
23913656	0	Simvastatin	0,11	MMP-9	30,35	Simvastatin	MMP-9	MESH:D019821	4318	Chemical	Gene	therapy|compound|START_ENTITY decreases|nsubj|therapy decreases|dobj|levels levels|compound|END_ENTITY	Simvastatin therapy decreases MMP-9 levels in obese women .
25316568	0	Simvastatin	0,11	MMP-9	117,122	Simvastatin	MMP-9	MESH:D019821	4318	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|down-regulation down-regulation|amod|matrix_metalloproteinase-9 matrix_metalloproteinase-9|dep|END_ENTITY	Simvastatin induces NFkB/p65 down-regulation and JNK1/c-Jun/ATF -2 activation , leading to matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- but not MMP-2 down-regulation in human leukemia cells .
21465237	0	Simvastatin	0,11	NF-kB	81,86	Simvastatin	NF-kB	MESH:D019821	81736(Tax:10116)	Chemical	Gene	has|nsubj|START_ENTITY has|advcl|inhibiting inhibiting|dobj|expression expression|amod|END_ENTITY	Simvastatin has beneficial effect on pulmonary_artery_hypertension by inhibiting NF-kB expression .
17178392	0	Simvastatin	0,11	NF-kappaB	21,30	Simvastatin	NF-kappaB	MESH:D019821	18033(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|signaling signaling|compound|END_ENTITY	Simvastatin inhibits NF-kappaB signaling in intestinal epithelial cells and ameliorates acute murine colitis .
18323503	0	Simvastatin	0,11	NMDA_receptors	39,53	Simvastatin	NMDA receptors	MESH:D019821	2902	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|nmod|END_ENTITY	Simvastatin reduces the association of NMDA_receptors to lipid rafts : a cholesterol-mediated effect in neuroprotection .
16005304	0	Simvastatin	0,11	NOR-1	21,26	Simvastatin	NOR-1	MESH:D019821	397479(Tax:9823)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Simvastatin inhibits NOR-1 expression induced by hyperlipemia by interfering with CREB activation .
19589242	0	Simvastatin	0,11	OX40	20,24	Simvastatin	OX40	MESH:D019821	7293	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|compound|END_ENTITY	Simvastatin reduces OX40 and OX40_ligand expression in human peripheral blood mononuclear cells and in patients with atherosclerotic_cerebral_infarction .
16542205	0	Simvastatin	0,11	P-glycoprotein	46,60	Simvastatin	P-glycoprotein	MESH:D019821	5243	Chemical	Gene	influence|nsubj|START_ENTITY influence|dobj|END_ENTITY	Simvastatin does not influence the intestinal P-glycoprotein and MPR2 , and the disposition of talinolol after chronic medication in healthy subjects genotyped for the ABCB1 , ABCC2 and SLCO1B1 polymorphisms .
24080182	0	Simvastatin	0,11	Prolyl-4-Hydroxylase_a1	22,45	Simvastatin	Prolyl-4-Hydroxylase a1	MESH:D019821	5033	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Simvastatin increases Prolyl-4-Hydroxylase_a1 expression in atherosclerotic_plaque and ox-LDL-stimulated human aortic smooth muscle cells via p38 MAPK and ERK1/2 signaling .
17112859	0	Simvastatin	0,11	RANTES	46,52	Simvastatin	RANTES	MESH:D019821	6352	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Simvastatin down regulates mRNA expression of RANTES and CCR5 in posttransplant renal recipients with hyperlipidemia .
23900131	0	Simvastatin	0,11	RhoA	87,91	Simvastatin	RhoA	MESH:D019821	117273(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|advcl|inhibiting inhibiting|dobj|END_ENTITY	Simvastatin attenuates formalin-induced nociceptive_behaviors by inhibiting microglial RhoA and p38 MAPK activation .
17184595	0	Simvastatin	0,11	TIMP-1	54,60	Simvastatin	TIMP-1	MESH:D019821	7076	Chemical	Gene	prevent|nsubj|START_ENTITY prevent|dobj|increase increase|nmod|ratio ratio|compound|END_ENTITY	Simvastatin could prevent increase of the serum MMP-9 / TIMP-1 ratio in acute ischaemic_stroke .
26322850	0	Simvastatin	0,11	TLR8	21,25	Simvastatin	TLR8	MESH:D019821	51311	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Simvastatin inhibits TLR8 signaling in primary human monocytes and spontaneous TNF production from rheumatoid synovial membrane cultures .
22245985	0	Simvastatin	0,11	VCAM-1	20,26	Simvastatin	VCAM-1	MESH:D019821	7412	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|compound|END_ENTITY	Simvastatin reduces VCAM-1 expression in human umbilical vein endothelial cells exposed to lipopolysaccharide .
12535662	0	Simvastatin	0,11	VEGF	23,27	Simvastatin	VEGF	MESH:D019821	83785(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|amod|END_ENTITY	Simvastatin stimulates VEGF release via p44/p42 MAP kinase in vascular smooth muscle cells .
18316203	0	Simvastatin	0,11	VEGF	21,25	Simvastatin	VEGF	MESH:D019821	22339(Tax:10090)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|amod|END_ENTITY	Simvastatin enhances VEGF production and ameliorates_impaired wound healing in experimental diabetes .
23543392	0	Simvastatin	0,11	VEGF_and_NO	20,31	Simvastatin	VEGF and NO	MESH:D019821	83785(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|levels levels|compound|END_ENTITY	Simvastatin reduces VEGF_and_NO levels in acute stages of experimental traumatic brain_injury .
17950796	0	Simvastatin	0,11	adiponectin	25,36	Simvastatin	adiponectin	MESH:D019821	9370	Chemical	Gene	START_ENTITY|appos|levels levels|compound|END_ENTITY	Simvastatin -LRB- 40 mg/day -RRB- , adiponectin levels , and insulin sensitivity in subjects with the metabolic_syndrome .
15213258	0	Simvastatin	0,11	angiotensin_II	22,36	Simvastatin	angiotensin II	MESH:D019821	24179(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Simvastatin modulates angiotensin_II signaling pathway by preventing Rac1-mediated upregulation of p27 .
20489687	0	Simvastatin	0,11	angiotensin_II	63,77	Simvastatin	angiotensin II	MESH:D019821	24179(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|nmod|END_ENTITY	Simvastatin reduces pressor response to centrally administered angiotensin_II .
21511701	0	Simvastatin	0,11	aquaporin-2	21,32	Simvastatin	aquaporin-2	MESH:D019821	25386(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Simvastatin enhances aquaporin-2 surface expression and urinary concentration in vasopressin-deficient Brattleboro rats through modulation of Rho GTPase .
20346376	0	Simvastatin	0,11	bone_morphogenetic_protein-2	59,87	Simvastatin	bone morphogenetic protein-2	MESH:D019821	650	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|differentiation differentiation|acl|induced induced|nmod|END_ENTITY	Simvastatin inhibits osteoclast differentiation induced by bone_morphogenetic_protein-2 and RANKL through regulating MAPK , AKT and Src signaling .
16297860	0	Simvastatin	0,11	bone_morphogenetic_protein_receptor_type_II	21,64	Simvastatin	bone morphogenetic protein receptor type II	MESH:D019821	659	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Simvastatin enhances bone_morphogenetic_protein_receptor_type_II expression .
16054375	0	Simvastatin	0,11	caspase-3	20,29	Simvastatin	caspase-3	MESH:D019821	25402(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|activation activation|amod|END_ENTITY	Simvastatin reduces caspase-3 activation and inflammatory markers induced by hypoxia-ischemia in the newborn rat .
19343037	0	Simvastatin	0,11	caspase-3	85,94	Simvastatin	caspase-3	MESH:D019821	836	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|parataxis|roles roles|acl|END_ENTITY	Simvastatin suppresses homocysteine-induced apoptosis in endothelial cells : roles of caspase-3 , cIAP-1 and cIAP-2 .
12962723	0	Simvastatin	0,11	caspase_9	76,85	Simvastatin	caspase 9	MESH:D019821	842	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Simvastatin induces apoptosis of B-CLL cells by activation of mitochondrial caspase_9 .
23239110	0	Simvastatin	0,11	cysteine-rich_protein_61	21,45	Simvastatin	cysteine-rich protein 61	MESH:D019821	83476(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Simvastatin inhibits cysteine-rich_protein_61 expression in rheumatoid_arthritis synovial fibroblasts through the regulation of sirtuin-1 / FoxO3a signaling .
18486135	0	Simvastatin	0,11	endothelial_cell_adhesion_molecule	25,59	Simvastatin	endothelial cell adhesion molecule	MESH:D019821	90952	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|expression expression|compound|END_ENTITY	Simvastatin alters human endothelial_cell_adhesion_molecule expression and inhibits leukocyte adhesion under flow .
18470660	0	Simvastatin	0,11	estrogen_receptor-alpha	20,43	Simvastatin	estrogen receptor-alpha	MESH:D019821	13982(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Simvastatin induces estrogen_receptor-alpha -LRB- ER-alpha -RRB- in murine bone marrow stromal cells .
15337692	0	Simvastatin	0,11	heme_oxygenase-1	20,36	Simvastatin	heme oxygenase-1	MESH:D019821	3162	Chemical	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Simvastatin induces heme_oxygenase-1 : a novel mechanism of vessel protection .
16628357	0	Simvastatin	1,12	heme_oxygenase-1	93,109	Simvastatin	heme oxygenase-1	MESH:D019821	24451(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|activation activation|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Simvastatin inhibits hypertension-induced cardiac_hypertrophy in rats through activation of heme_oxygenase-1 / carbon_monoxide pathway -RSB- .
19409105	0	Simvastatin	0,11	heme_oxygenase-1	69,85	Simvastatin	heme oxygenase-1	MESH:D019821	24451(Tax:10116)	Chemical	Gene	ameliorates|compound|START_ENTITY established|nsubj|ameliorates established|nmod|pathway pathway|amod|dependent dependent|amod|END_ENTITY	Simvastatin ameliorates established pulmonary_hypertension through a heme_oxygenase-1 dependent pathway in rats .
20018301	0	Simvastatin	0,11	heme_oxygenase-1	20,36	Simvastatin	heme oxygenase-1	MESH:D019821	24451(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Simvastatin induces heme_oxygenase-1 expression but fails to reduce inflammation in the capsule surrounding a silicone shell implant in rats .
20171361	0	Simvastatin	0,11	heme_oxygenase-1	92,108	Simvastatin	heme oxygenase-1	MESH:D019821	3162	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|differentiation differentiation|nmod|factors factors|nmod|cells cells|amod|END_ENTITY	Simvastatin promotes odontoblastic differentiation and expression of angiogenic factors via heme_oxygenase-1 in primary cultured human dental pulp cells .
21925249	0	Simvastatin	0,11	heme_oxygenase-1	69,85	Simvastatin	heme oxygenase-1	MESH:D019821	3162	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|induction induction|nmod|expression expression|amod|END_ENTITY	Simvastatin inhibits pro-inflammatory mediators through induction of heme_oxygenase-1 expression in lipopolysaccharide-stimulated RAW264 .7 macrophages .
17327694	0	Simvastatin	0,11	insulin-like_growth_factor-1	20,48	Simvastatin	insulin-like growth factor-1	MESH:D019821	16000(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|xcomp|END_ENTITY	Simvastatin reduces insulin-like_growth_factor-1 signaling in differentiating C2C12 mouse myoblast cells in an HMG-CoA reductase inhibition-independent manner .
15149889	0	Simvastatin	0,11	interleukin-1beta	20,37	Simvastatin	interleukin-1beta	MESH:D019821	3553	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|secretion secretion|amod|END_ENTITY	Simvastatin reduces interleukin-1beta secretion by peripheral blood mononuclear cells in patients with essential_hypertension .
12117737	0	Simvastatin	0,11	interleukin-6	44,57	Simvastatin	interleukin-6	MESH:D019821	3569	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|acl|END_ENTITY	Simvastatin reduces expression of cytokines interleukin-6 , interleukin-8 , and monocyte_chemoattractant_protein-1 in circulating monocytes from hypercholesterolemic patients .
12826933	0	Simvastatin	0,11	interleukin-6	21,34	Simvastatin	interleukin-6	MESH:D019821	3569	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|amod|END_ENTITY	Simvastatin inhibits interleukin-6 release in human monocytes stimulated by C-reactive_protein and lipopolysaccharide .
17466485	0	Simvastatin	0,11	interleukin-6	35,48	Simvastatin	interleukin-6	MESH:D019821	3569	Chemical	Gene	reduce|nsubj|START_ENTITY reduce|dobj|lipopolysaccharide lipopolysaccharide|amod|END_ENTITY	Simvastatin and fluvastatin reduce interleukin-6 and interleukin-8 lipopolysaccharide -LRB- LPS -RRB- stimulated production by isolated human monocytes from chronic_kidney_disease_patients .
22922248	0	Simvastatin	0,11	interleukin-6	38,51	Simvastatin	interleukin-6	MESH:D019821	3569	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|dobj|induction induction|nmod|expression expression|amod|END_ENTITY	Simvastatin prevents the induction of interleukin-6 gene expression by titanium particles in human osteoblastic cells .
15194586	0	Simvastatin	0,11	interleukin_1beta	35,52	Simvastatin	interleukin 1beta	MESH:D019821	3553	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|nmod|END_ENTITY	Simvastatin reduces MMP-3 level in interleukin_1beta stimulated human chondrocyte culture .
16511915	0	Simvastatin	0,11	interleukin_6	35,48	Simvastatin	interleukin 6	MESH:D019821	3569	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|nmod|END_ENTITY	Simvastatin inhibits production of interleukin_6 -LRB- IL-6 -RRB- and IL-8 and cell proliferation induced by tumor_necrosis_factor-alpha in fibroblast-like_synoviocytes from patients with rheumatoid_arthritis .
19254925	0	Simvastatin	0,11	leptin	23,29	Simvastatin	leptin	MESH:D019821	16846(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Simvastatin suppresses leptin expression in 3T3-L1 adipocytes via activation of the cyclic_AMP-PKA pathway induced by inhibition of protein prenylation .
17399814	0	Simvastatin	0,11	monocyte_chemoattractant_protein-1	116,150	Simvastatin	monocyte chemoattractant protein-1	MESH:D019821	6347	Chemical	Gene	exerts|nsubj|START_ENTITY exerts|advcl|decreasing decreasing|dobj|levels levels|nmod|END_ENTITY	Simvastatin exerts its anti-inflammatory effect in hypercholesterolaemic patients by decreasing the serum levels of monocyte_chemoattractant_protein-1 .
18927449	0	Simvastatin	0,11	notch	22,27	Simvastatin	notch	MESH:D019821	25496(Tax:10116)	Chemical	Gene	increases|compound|START_ENTITY END_ENTITY|nsubj|increases	Simvastatin increases notch signaling activity and promotes arteriogenesis after stroke .
19864567	0	Simvastatin	0,11	p21ras	39,45	Simvastatin	p21ras	MESH:D019821	15461(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	Simvastatin inhibits the activation of p21ras and prevents the loss of dopaminergic neurons in a mouse model of Parkinson 's _ disease .
17094942	0	Simvastatin	0,11	tumor_necrosis_factor-alpha	48,75	Simvastatin	tumor necrosis factor-alpha	MESH:D019821	24835(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Simvastatin inhibits lipopolysaccharide-induced tumor_necrosis_factor-alpha expression in neonatal rat cardiomyocytes : The role of reactive oxygen species .
18310456	0	Simvastatin	0,11	tumor_necrosis_factor-alpha	24,51	Simvastatin	tumor necrosis factor-alpha	MESH:D019821	21926(Tax:10090)	Chemical	Gene	antagonizes|nsubj|START_ENTITY antagonizes|dobj|inhibition inhibition|amod|END_ENTITY	Simvastatin antagonizes tumor_necrosis_factor-alpha inhibition of bone morphogenetic proteins-2-induced osteoblast differentiation by regulating Smad signaling and Ras/Rho-mitogen-activated protein kinase pathway .
16424782	0	Simvastatin	0,11	vascular_endothelial_growth_factor	35,69	Simvastatin	vascular endothelial growth factor	MESH:D019821	7422	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|level level|nmod|END_ENTITY	Simvastatin reduces serum level of vascular_endothelial_growth_factor in hypercholesterolemic patients .
18356691	0	Simvastatin	0,11	vascular_endothelial_growth_factor	23,57	Simvastatin	vascular endothelial growth factor	MESH:D019821	7422	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|compound|END_ENTITY	Simvastatin stimulates vascular_endothelial_growth_factor production by hypoxia-inducible_factor-1alpha upregulation in endothelial cells .
26870226	0	Sinomenine	0,10	COX-2	14,19	Sinomenine	COX-2	MESH:C009271	4513	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Sinomenine , a COX-2 inhibitor , induces cell cycle arrest and inhibits growth of human colon_carcinoma cells in vitro and in vivo .
23605561	0	Sinomenine	0,10	MyD88	21,26	Sinomenine	MyD88	MESH:C009271	301059(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|amod|END_ENTITY	Sinomenine decreases MyD88 expression and improves inflammation-induced joint damage progression and symptoms in rat adjuvant-induced_arthritis .
26795599	0	Sinomenine	0,10	Nrf2	25,29	Sinomenine	Nrf2	MESH:C009271	18024(Tax:10090)	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Sinomenine activation of Nrf2 signaling prevents hyperactive inflammation and kidney_injury in a mouse model of obstructive_nephropathy .
17869461	0	Sinomenine	0,10	VCAM-1	40,46	Sinomenine	VCAM-1	MESH:C009271	7412	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Sinomenine suppresses TNF-alpha-induced VCAM-1 expression in human umbilical vein endothelial cells .
23554784	0	Sinomenine	0,10	iNOS	19,23	Sinomenine	iNOS	MESH:C009271	24599(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|iobj|END_ENTITY	Sinomenine reduces iNOS expression via inhibiting the T-bet IFN-y pathway in experimental_autoimmune_encephalomyelitis in rats .
17640301	0	Sipholenol_A	0,12	P-glycoprotein	71,85	Sipholenol A	P-glycoprotein	MESH:C523549	5243	Chemical	Gene	reverses|nsubj|START_ENTITY reverses|dobj|END_ENTITY	Sipholenol_A , a marine-derived sipholane_triterpene , potently reverses P-glycoprotein -LRB- ABCB1 -RRB- - mediated multidrug resistance in cancer cells .
23375290	0	Sirolimus	0,9	CD25	31,35	Sirolimus	CD25	MESH:D020123	3559	Chemical	Gene	affect|nsubj|START_ENTITY affect|dobj|END_ENTITY	Sirolimus did not affect CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- forkhead_box_p3 -LRB- + -RRB- T cells of peripheral blood in renal transplant recipients .
24159565	0	Sirolimus	198,207	VEGF-D	6,12	Sirolimus	VEGF-D	MESH:D020123	2277	Chemical	Gene	trial|compound|START_ENTITY analysis|nmod|trial Serum|dep|analysis Serum|acl|END_ENTITY	Serum VEGF-D a concentration as a biomarker of lymphangioleiomyomatosis severity and treatment response : a prospective analysis of the Multicenter International Lymphangioleiomyomatosis Efficacy of Sirolimus -LRB- MILES -RRB- trial .
15686734	0	Sirolimus	0,9	aP2	22,25	Sirolimus	aP2	MESH:D020123	2167	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Sirolimus upregulates aP2 expression in human monocytes and macrophages .
27030639	0	Sirolimus	84,93	mTOR	68,72	Sirolimus	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	Induced|nsubj|START_ENTITY Induced|nmod|inhibitor inhibitor|compound|END_ENTITY	Combination Targeted Therapy of VEGFR Inhibitor , Sorafenib , with an mTOR inhibitor , Sirolimus Induced a Remakable Response of Rapid progressive Uterine PEComa .
26718407	0	Sirtinol	31,39	CBX8	0,4	Sirtinol	CBX8	MESH:C439060	57332	Chemical	Gene	effect|nmod|START_ENTITY antagonizes|dobj|effect antagonizes|nsubj|END_ENTITY	CBX8 antagonizes the effect of Sirtinol on premature senescence through the AKT-RB-E2F1 pathway in K562 leukemia cells .
23474493	5	Sirtinol	723,731	SIRT1	674,679	Sirtinol	SIRT1	MESH:C439060	23411	Chemical	Gene	induced|nmod|START_ENTITY acetylation|acl|induced suppressing|dobj|acetylation cooperated|advcl|suppressing cooperated|nmod|END_ENTITY	CBX8 cooperated with SIRT1 for suppressing p53 acetylation induced by Sirtinol and etoposide/TSA .
16170353	0	Sirtinol	17,25	Sirt1	0,5	Sirtinol	Sirt1	MESH:C439060	23411	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Sirt1 inhibitor , Sirtinol , induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells .
3471390	0	Sis	30,33	Myc	25,28	Sis	Myc	null	17869(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Mapping Mapping|nmod|END_ENTITY	Mapping of the oncogenes Myc , Sis , and int-1 to the distal part of mouse chromosome 15 .
26198273	0	Sitagliptin	0,11	Apolipoprotein_C1	47,64	Sitagliptin	Apolipoprotein C1	MESH:C496398	341	Chemical	Gene	Results|compound|START_ENTITY Results|nmod|END_ENTITY	Sitagliptin Results in a Decrease of Truncated Apolipoprotein_C1 .
26198273	0	Sitagliptin	0,11	Apolipoprotein_C1	47,64	Sitagliptin	Apolipoprotein C1	MESH:C496398	341	Chemical	Gene	Results|compound|START_ENTITY Results|nmod|END_ENTITY	Sitagliptin Results in a Decrease of Truncated Apolipoprotein_C1 .
17315049	0	Sitagliptin	0,11	DPP-4	32,37	Sitagliptin	DPP-4	MESH:C496398	1803	Chemical	Gene	START_ENTITY|dep|Profile Profile|nmod|inhibitor inhibitor|compound|END_ENTITY	Sitagliptin : Profile of a novel DPP-4 inhibitor for the treatment of type 2 diabetes .
18174966	0	Sitagliptin	0,11	DPP-4	32,37	Sitagliptin	DPP-4	MESH:C496398	1803	Chemical	Gene	START_ENTITY|dep|profile profile|nmod|inhibitor inhibitor|compound|END_ENTITY	Sitagliptin : profile of a novel DPP-4 inhibitor for the treatment of type 2 diabetes -LRB- update -RRB- .
18182122	0	Sitagliptin	0,11	DPP-4	15,20	Sitagliptin	DPP-4	MESH:C496398	1803	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Sitagliptin , a DPP-4 inhibitor for the treatment of patients with type 2 diabetes : a review of recent clinical trials .
19691426	0	Sitagliptin	0,11	DPP-4	35,40	Sitagliptin	DPP-4	MESH:C496398	1803	Chemical	Gene	mg|nsubj|START_ENTITY mg|nmod|inhibition inhibition|compound|END_ENTITY	Sitagliptin 100 mg daily effect on DPP-4 inhibition and compound-specific glycemic improvement .
22864134	0	Sitagliptin	0,11	DPP-4	13,18	Sitagliptin	DPP-4	MESH:C496398	1803	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Sitagliptin -LRB- DPP-4 inhibitor -RRB- - induced rheumatoid_arthritis in type_2_diabetes_mellitus : a case report .
24584549	0	Sitagliptin	0,11	DPP-4	15,20	Sitagliptin	DPP-4	MESH:C496398	1803	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Sitagliptin , a DPP-4 inhibitor , acutely inhibits intestinal lipoprotein particle secretion in healthy humans .
24809328	0	Sitagliptin	99,110	DPP-4	68,73	Sitagliptin	DPP-4	MESH:C496398	1803	Chemical	Gene	Diprotin-A|compound|START_ENTITY Understanding|nmod|Diprotin-A Understanding|dobj|Dynamics Dynamics|nmod|END_ENTITY	Understanding the Molecular Dynamics of Type-2 Diabetes Drug Target DPP-4 and its Interaction with Sitagliptin and Inhibitor Diprotin-A .
26508675	0	Sitagliptin	0,11	DPP-4	15,20	Sitagliptin	DPP-4	MESH:C496398	1803	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Sitagliptin , a DPP-4 inhibitor , alters the subsets of circulating CD4 + T cells in patients with type 2 diabetes .
25756669	0	Sitagliptin	57,68	DPP4	15,19	Sitagliptin	DPP4	MESH:C496398	1803	Chemical	Gene	QSAR|compound|START_ENTITY Based|nmod|QSAR Based|nsubj|Inhibitors Inhibitors|compound|END_ENTITY	More Effective DPP4 Inhibitors as Antidiabetics Based on Sitagliptin Applied QSAR and Clinical Methods .
26420287	0	Sitagliptin	91,102	G-CSF	105,110	Sitagliptin	G-CSF	MESH:C496398	12985(Tax:10090)	Chemical	Gene	therapy|compound|START_ENTITY therapy|compound|END_ENTITY	FDG-PET reveals improved cardiac regeneration and attenuated adverse remodelling following Sitagliptin + G-CSF therapy after acute_myocardial_infarction .
21932180	0	Sitagliptin	0,11	GLP-1	43,48	Sitagliptin	GLP-1	MESH:C496398	100125288	Chemical	Gene	augments|nsubj|START_ENTITY augments|dobj|effects effects|nmod|END_ENTITY	Sitagliptin augments protective effects of GLP-1 against advanced glycation end product receptor axis in endothelial cells .
24738001	0	Sitagliptin	34,45	GLP-1	90,95	Sitagliptin	GLP-1	MESH:C496398	2641	Chemical	Gene	Hyperglycemia|compound|START_ENTITY Therapy|nmod|Hyperglycemia Caused|nsubj|Therapy Caused|nmod|Tachyphylaxis Tachyphylaxis|compound|END_ENTITY	Basal-Supported Oral Therapy with Sitagliptin Counteracts Rebound Hyperglycemia Caused by GLP-1 Tachyphylaxis .
25500876	0	Sitagliptin	0,11	GLP-1	92,97	Sitagliptin	GLP-1	MESH:C496398	25051(Tax:10116)	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|acute_ischemia-reperfusion_injury acute_ischemia-reperfusion_injury|nmod|upregulation upregulation|nmod|END_ENTITY	Sitagliptin protects rat kidneys from acute_ischemia-reperfusion_injury via upregulation of GLP-1 and GLP-1_receptors .
20368408	0	Sitagliptin	0,11	MK0431	13,19	Sitagliptin	MK0431	MESH:C496398	1477734(Tax:190192)	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Sitagliptin -LRB- MK0431 -RRB- inhibition of dipeptidyl_peptidase_IV decreases nonobese diabetic mouse CD4 + T-cell migration through incretin-dependent and - independent pathways .
18503607	0	Sitagliptin	0,11	dipeptidyl_peptidase-4	16,38	Sitagliptin	dipeptidyl peptidase-4	MESH:C496398	1803	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Sitagliptin , an dipeptidyl_peptidase-4 inhibitor , does not alter the pharmacokinetics of the sulphonylurea , glyburide , in healthy subjects .
21209231	0	Sitagliptin	0,11	dipeptidyl_peptidase-4	15,37	Sitagliptin	dipeptidyl peptidase-4	MESH:C496398	1803	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Sitagliptin , a dipeptidyl_peptidase-4 inhibitor , does not affect the pharmacokinetics of ethinyl_estradiol or norethindrone in healthy female subjects .
21304217	0	Sitagliptin	0,11	dipeptidyl_peptidase-4	15,37	Sitagliptin	dipeptidyl peptidase-4	MESH:C496398	1803	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Sitagliptin , a dipeptidyl_peptidase-4 inhibitor , decreases systolic blood pressure in Japanese hypertensive patients with type 2 diabetes .
23649733	0	Sitagliptin	25,36	dipeptidyl_peptidase-4	40,62	Sitagliptin	dipeptidyl peptidase-4	MESH:C496398	25253(Tax:10116)	Chemical	Gene	treatment|nmod|START_ENTITY treatment|appos|inhibitor inhibitor|amod|END_ENTITY	Long-term treatment with Sitagliptin , a dipeptidyl_peptidase-4 inhibitor , reduces colon_carcinogenesis and reactive oxygen species in 1,2-dimethylhydrazine-induced rats .
25580570	0	Sitagliptin	0,11	dipeptidyl_peptidase-4	15,37	Sitagliptin	dipeptidyl peptidase-4	MESH:C496398	13482(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Sitagliptin , a dipeptidyl_peptidase-4 inhibitor , improves recognition memory , oxidative stress and hippocampal neurogenesis and upregulates key genes involved in cognitive_decline .
20927248	0	Sitagliptin	20,31	dipeptidyl_peptidase-IV	37,60	Sitagliptin	dipeptidyl peptidase-IV	MESH:C496398	1803	Chemical	Gene	action|nmod|START_ENTITY Nature|nmod|action Nature|appos|inhibitor inhibitor|amod|END_ENTITY	Nature of action of Sitagliptin , the dipeptidyl_peptidase-IV inhibitor in diabetic animals .
22056790	0	Sitagliptin	0,11	dipeptidyl_peptidase-IV	15,38	Sitagliptin	dipeptidyl peptidase-IV	MESH:C496398	1803	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Sitagliptin , a dipeptidyl_peptidase-IV inhibitor , improves psoriasis .
16868220	0	Sitagliptin	0,11	dipeptidyl_peptidase_IV	15,38	Sitagliptin	dipeptidyl peptidase IV	MESH:C496398	1803	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Sitagliptin : a dipeptidyl_peptidase_IV inhibitor for the treatment of type 2 diabetes .
17352677	0	Sitagliptin	22,33	dipeptidyl_peptidase_IV	48,71	Sitagliptin	dipeptidyl peptidase IV	MESH:C496398	25253(Tax:10116)	Chemical	Gene	JANUVIA|appos|START_ENTITY Discovery|nmod|JANUVIA Discovery|appos|inhibitor inhibitor|amod|END_ENTITY	Discovery of JANUVIA -LRB- Sitagliptin -RRB- , a selective dipeptidyl_peptidase_IV inhibitor for the treatment of type 2 diabetes .
20368408	0	Sitagliptin	0,11	dipeptidyl_peptidase_IV	35,58	Sitagliptin	dipeptidyl peptidase IV	MESH:C496398	13482(Tax:10090)	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Sitagliptin -LRB- MK0431 -RRB- inhibition of dipeptidyl_peptidase_IV decreases nonobese diabetic mouse CD4 + T-cell migration through incretin-dependent and - independent pathways .
26811539	0	Sitagliptin	0,11	glucose-dependent_insulinotropic_polypeptide	60,104	Sitagliptin	glucose-dependent insulinotropic polypeptide	MESH:C496398	25040(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|nmod|END_ENTITY	Sitagliptin decreases ventricular_arrhythmias by attenuated glucose-dependent_insulinotropic_polypeptide -LRB- GIP -RRB- - dependent resistin signaling in infarcted rats .
26770384	0	Sitagliptin	0,11	glucose_transporter_type_4	68,94	Sitagliptin	glucose transporter type 4	MESH:C496398	25139(Tax:10116)	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	Sitagliptin downregulates retinol-binding_protein_4 and upregulates glucose_transporter_type_4 expression in a type_2_diabetes_mellitus rat model .
26770384	0	Sitagliptin	0,11	retinol-binding_protein_4	26,51	Sitagliptin	retinol-binding protein 4	MESH:C496398	25703(Tax:10116)	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	Sitagliptin downregulates retinol-binding_protein_4 and upregulates glucose_transporter_type_4 expression in a type_2_diabetes_mellitus rat model .
18201579	0	Sitagliptin_phosphate	0,21	DPP-4	25,30	Sitagliptin phosphate	DPP-4	MESH:C496398	1803	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Sitagliptin_phosphate : a DPP-4 inhibitor for the treatment of type_2_diabetes_mellitus .
15500395	0	Sitaxsentan	0,11	endothelin-A	25,37	Sitaxsentan	endothelin-A	MESH:C106276	1909	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Sitaxsentan , a selective endothelin-A receptor antagonist for the treatment of pulmonary_arterial_hypertension .
19963159	0	Sitosterol	0,10	Niemann-Pick_C1-like_1	66,88	Sitosterol	Niemann-Pick C1-like 1	MESH:C025473	29881	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|levels levels|nmod|END_ENTITY	Sitosterol reduces messenger RNA and protein expression levels of Niemann-Pick_C1-like_1 in FHs_74_Int cells .
21221803	0	Sivelestat	0,10	iNOS	22,26	Sivelestat	iNOS	MESH:C069195	24599(Tax:10116)	Chemical	Gene	suppresses|amod|START_ENTITY END_ENTITY|nsubj|suppresses	Sivelestat suppresses iNOS gene expression in proinflammatory cytokine-stimulated hepatocytes .
20650263	0	Sodium	0,6	ATPase	27,33	Sodium	ATPase	MESH:D012964	1769	Chemical	Gene	efflux|compound|START_ENTITY END_ENTITY|nsubj|efflux	Sodium or potassium efflux ATPase a fungal , bryophyte , and protozoal ATPase .
26230832	0	Sodium	61,67	Angiotensin_II	12,26	Sodium	Angiotensin II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	Transport|compound|START_ENTITY Role|nmod|Transport Role|nmod|END_ENTITY	The Role of Angiotensin_II and Cyclic_AMP in Alveolar Active Sodium Transport .
26308209	0	Sodium	73,79	Angiotensin_II	24,38	Sodium	Angiotensin II	MESH:D012964	183	Chemical	Gene	Transport|compound|START_ENTITY Role|nmod|Transport Role|nmod|END_ENTITY	Correction : The Role of Angiotensin_II and Cyclic_AMP in Alveolar Active Sodium Transport .
25817868	0	Sodium	25,31	Bradykinin	70,80	Sodium	Bradykinin	MESH:D012964	3827	Chemical	Gene	Reabsorption|compound|START_ENTITY Control|nmod|Reabsorption Control|nmod|END_ENTITY	Control of ENaC-Mediated Sodium Reabsorption in the Distal Nephron by Bradykinin .
11744120	0	Sodium	0,6	CA1	69,72	Sodium	CA1	MESH:D012964	310218(Tax:10116)	Chemical	Gene	currents|amod|START_ENTITY currents|nmod|END_ENTITY	Sodium channel currents in maturing acutely isolated rat hippocampal CA1 neurones .
9692746	0	Sodium	0,6	CA1	32,35	Sodium	CA1	MESH:D012964	310218(Tax:10116)	Chemical	Gene	currents|amod|START_ENTITY currents|nmod|END_ENTITY	Sodium currents in isolated rat CA1 neurons after kindling epileptogenesis .
9794743	0	Sodium	0,6	CO2	63,66	Sodium	CO2	MESH:D012964	717	Chemical	Gene	sensitivity|amod|START_ENTITY sensitivity|nmod|END_ENTITY	Sodium sensitivity in young adults with high resting end-tidal CO2 .
25164814	0	Sodium	97,103	ENaC	82,86	Sodium	ENaC	MESH:D012964	24768(Tax:10116)	Chemical	Gene	Reabsorption|compound|START_ENTITY mediated|nsubj|Reabsorption Role|parataxis|mediated Role|nmod|Epithelial_Sodium_Channel Epithelial_Sodium_Channel|appos|END_ENTITY	Role of Rho GDP Dissociation Inhibitor a in Control of Epithelial_Sodium_Channel -LRB- ENaC -RRB- - mediated Sodium Reabsorption .
17522178	0	Sodium	0,6	Nav1	57,61	Sodium	Nav1	MESH:D012964	215690(Tax:10090)	Chemical	Gene	currents|amod|START_ENTITY neurons|nsubj|currents neurons|nmod|mice mice|nummod|.6 .6|compound|END_ENTITY	Sodium currents in mesencephalic trigeminal neurons from Nav1 .6 null mice .
25285947	0	Sodium	32,38	Nav1	47,51	Sodium	Nav1	MESH:D012964	89796	Chemical	Gene	Mutation|compound|START_ENTITY Mutation|compound|END_ENTITY	p.L1612P , a Novel Voltage-gated Sodium Channel Nav1 .7 Mutation Inducing a Cold Sensitive Paroxysmal Extreme Pain_Disorder .
27013956	0	Sodium	70,76	Nav1	85,89	Sodium	Nav1	MESH:D012964	215690(Tax:10090)	Chemical	Gene	Channel|compound|START_ENTITY Modulation|nmod|Channel Excitability|nmod|Modulation END_ENTITY|nsubj|Excitability	Elevated Neuronal Excitability Due to Modulation of the Voltage-Gated Sodium Channel Nav1 .6 by Ab1-42 .
12610651	0	Sodium	0,6	SCN1A	16,21	Sodium	SCN1A	MESH:D012964	6323	Chemical	Gene	channels|amod|START_ENTITY channels|dep|END_ENTITY	Sodium channels SCN1A , SCN2A and SCN3A in familial autism .
24436055	0	Sodium	27,33	SCN1A	42,47	Sodium	SCN1A	MESH:D012964	6323	Chemical	Gene	Gene|compound|START_ENTITY Gene|compound|END_ENTITY	Transcription of the Human Sodium Channel SCN1A Gene Is Repressed by a Scaffolding Protein RACK1 .
22323988	0	Sodium	84,90	SCN5A	58,63	Sodium	SCN5A	MESH:D012964	6331	Chemical	Gene	Channelopathy|compound|START_ENTITY Channelopathy|compound|END_ENTITY	The Relationship Between Gastric Myoelectric Activity and SCN5A Mutation Suggesting Sodium Channelopathy in Patients With Brugada_Syndrome and Functional Dyspepsia - A Pilot Study .
26146998	0	Sodium	43,49	SCN5A	73,78	Sodium	SCN5A	MESH:D012964	6331	Chemical	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	A Common Polymorphism of the Human Cardiac Sodium Channel Alpha Subunit -LRB- SCN5A -RRB- Gene Is Associated with Sudden_Cardiac_Death in Chronic_Ischemic_Heart_Disease .
26553437	0	Sodium	54,60	SCN8A	20,25	Sodium	SCN8A	MESH:D012964	6334	Chemical	Gene	Blockers|compound|START_ENTITY Treated|nmod|Blockers Treated|compound|END_ENTITY	Precision Medicine : SCN8A Encephalopathy Treated with Sodium Channel Blockers .
11496924	0	Sodium	0,6	Scn8a	56,61	Sodium	Scn8a	MESH:D012964	20273(Tax:10090)	Chemical	Gene	channels|amod|START_ENTITY channels|dep|insights insights|nmod|mutations mutations|amod|END_ENTITY	Sodium channels and neurological_disease : insights from Scn8a mutations in the mouse .
27038931	0	Sodium	63,69	Stromal_Cell-Derived_Factor_1	0,29	Sodium	Stromal Cell-Derived Factor 1	MESH:D012964	24772(Tax:10116)	Chemical	Gene	Currents|compound|START_ENTITY Currents|compound|END_ENTITY	Stromal_Cell-Derived_Factor_1 Increases Tetrodotoxin-Resistant Sodium Currents Nav1 .8 and Nav1 .9 in Rat Dorsal Root Ganglion Neurons via Different Mechanisms .
26504355	0	Sodium	28,34	Tumor_Necrosis_Factor_Receptor-1	61,93	Sodium	Tumor Necrosis Factor Receptor-1	MESH:D012964	25625(Tax:10116)	Chemical	Gene	Channels|compound|START_ENTITY Modulation|nmod|Channels Modulation|nmod|END_ENTITY	Modulation of Voltage-Gated Sodium Channels by Activation of Tumor_Necrosis_Factor_Receptor-1 and Receptor-2 in Small DRG Neurons of Rats .
12595301	0	Sodium	0,6	angiotensin_II	72,86	Sodium	angiotensin II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	restriction|amod|START_ENTITY prevents|nsubj|restriction prevents|dobj|stress stress|nmod|hypertension hypertension|amod|END_ENTITY	Sodium restriction prevents cardiac_hypertrophy and oxidative stress in angiotensin_II hypertension .
1278538	0	Sodium	1,7	angiotensin_II	70,84	Sodium	angiotensin II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	release|nsubj|START_ENTITY release|nmod|influence influence|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Sodium release from tissue paracellular space under the influence of angiotensin_II -RSB- .
19816037	0	Sodium	0,6	angiotensin_II	49,63	Sodium	angiotensin II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	load|amod|START_ENTITY load|nmod|doses doses|nmod|END_ENTITY	Sodium load combined with low doses of exogenous angiotensin_II upregulate intrarenal angiotensin_II .
19816037	0	Sodium	0,6	angiotensin_II	86,100	Sodium	angiotensin II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	load|amod|START_ENTITY upregulate|nsubj|load upregulate|dobj|END_ENTITY	Sodium load combined with low doses of exogenous angiotensin_II upregulate intrarenal angiotensin_II .
3011198	0	Sodium	0,6	angiotensin_II	17,31	Sodium	angiotensin II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|receptors receptors|amod|END_ENTITY	Sodium increases angiotensin_II receptors in neuronal cultures from brains of normotensive and hypertensive rats .
94387	0	Sodium	0,6	angiotensin_II	80,94	Sodium	angiotensin II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	intake|amod|START_ENTITY intake|nmod|modulators modulators|nmod|receptors receptors|compound|END_ENTITY	Sodium intake and plasma angiotensin level as modulators of adrenal and uterine angiotensin_II receptors in the rat .
14761957	0	Sodium	0,6	beta1	15,20	Sodium	beta1	MESH:D012964	3779	Chemical	Gene	channel|advmod|START_ENTITY channel|dobj|modulation modulation|amod|END_ENTITY	Sodium channel beta1 subunit-mediated modulation of Nav1 .2 currents and cell surface density is dependent on interactions with contactin and ankyrin .
12930796	0	Sodium	0,6	beta2	82,87	Sodium	beta2	MESH:D012964	10242	Chemical	Gene	beta4|amod|START_ENTITY beta4|appos|subunit subunit|nmod|similarity similarity|nmod|END_ENTITY	Sodium channel beta4 , a new disulfide-linked auxiliary subunit with similarity to beta2 .
25098339	0	Sodium	0,6	hH3R	18,22	Sodium	hH3R	MESH:D012964	11255	Chemical	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	Sodium binding to hH3R and hH_4R -- a molecular modeling study .
1988777	0	Sodium	0,6	insulin	20,27	Sodium	insulin	MESH:D012964	3630	Chemical	Gene	retention|amod|START_ENTITY retention|nmod|END_ENTITY	Sodium retention by insulin may depend on decreased plasma potassium .
2533110	0	Sodium	0,6	insulin	21,28	Sodium	insulin	MESH:D012964	3630	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|nmod|END_ENTITY	Sodium metabolism in insulin dependent diabetic patients .
466476	0	Sodium	0,6	nerve_growth_factor	25,44	Sodium	nerve growth factor	MESH:D012964	396466(Tax:9031)	Chemical	Gene	dependence|amod|START_ENTITY dependence|nmod|END_ENTITY	Sodium dependence of the nerve_growth_factor -- regulated hexose uptake in chick embryo ganglionic cells .
25435878	0	Sodium	35,41	p38	99,102	Sodium	p38	MESH:D012964	81649(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|Inhibition Inhibition|nmod|END_ENTITY	The Protective Effect of Beraprost Sodium on Diabetic_Cardiomyopathy through the Inhibition of the p38 MAPK Signaling Pathway in High-Fat-Induced SD Rats .
633132	0	Sodium	0,6	prolactin	51,60	Sodium	prolactin	MESH:D012964	100009394(Tax:9986)	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|nmod|aldosterone aldosterone|compound|END_ENTITY	Sodium and water metabolism under the influence of prolactin , aldosterone , and antidiuretic hormone .
2970225	0	Sodium	0,6	renin	26,31	Sodium	renin	MESH:D012964	24715(Tax:10116)	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|angiotensinogen angiotensinogen|compound|END_ENTITY	Sodium balance effects on renin , angiotensinogen , and atrial natriuretic polypeptide mRNA levels .
3894515	0	Sodium	0,6	renin	82,87	Sodium	renin	MESH:D012964	5972	Chemical	Gene	restriction|amod|START_ENTITY lowers|nsubj|restriction lowers|nmod|response response|nmod|system system|compound|END_ENTITY	Sodium restriction lowers high blood pressure through a decreased response of the renin system -- direct evidence using saralasin .
6994958	0	Sodium	0,6	renin	26,31	Sodium	renin	MESH:D012964	24715(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|activity activity|compound|END_ENTITY	Sodium balance and plasma renin activity during the development of two-kidney Goldblatt hypertension in rats .
7030526	0	Sodium	0,6	renin	59,64	Sodium	renin	MESH:D012964	5972	Chemical	Gene	START_ENTITY|dep|determinants determinants|nmod|activity activity|compound|END_ENTITY	Sodium , potassium and age : possible determinants of plasma renin activity and aldosterone during childhood -LRB- age 4-16 -RRB- .
7036720	0	Sodium	0,6	renin	58,63	Sodium	renin	MESH:D012964	5972	Chemical	Gene	intake|compound|START_ENTITY alters|nsubj|intake alters|nmod|system system|compound|END_ENTITY	Sodium intake alters the effects of norepinephrine on the renin system and the kidney .
7943299	4	Sodium	617,623	renin	674,679	Sodium	renin	MESH:D012964	24715(Tax:10116)	Chemical	Gene	restriction|amod|START_ENTITY caused|nsubj|restriction caused|dobj|increases increases|nmod|activity activity|compound|END_ENTITY	Sodium restriction caused sustained increases of adrenal renin activity -LRB- from 28.5 + / - 3.5 to 87.5 + / - 4.5 ng.mg protein-1 .
8872843	0	Sodium	0,6	renin	94,99	Sodium	renin	MESH:D012964	5972	Chemical	Gene	sensitivity|amod|START_ENTITY related|nsubjpass|sensitivity related|nmod|sodium sodium|nmod|END_ENTITY	Sodium sensitivity of blood pressure in hypertensives is not related to sodium , but rather to renin .
9170003	0	Sodium	0,6	renin	24,29	Sodium	renin	MESH:D012964	24715(Tax:10116)	Chemical	Gene	intake|compound|START_ENTITY regulates|nsubj|intake regulates|dobj|expression expression|amod|END_ENTITY	Sodium intake regulates renin gene expression differently in the hypothalamus and kidney of rats .
11404244	0	Sodium_4-phenylbutyrate	0,23	HSC70	38,43	Sodium 4-phenylbutyrate	HSC70	MESH:C075773	3312	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|compound|END_ENTITY	Sodium_4-phenylbutyrate downregulates HSC70 expression by facilitating mRNA degradation .
15389886	0	Sodium_4-phenylbutyrate	0,23	JNK	91,94	Sodium 4-phenylbutyrate	JNK	MESH:C075773	5599	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|activating activating|dobj|END_ENTITY	Sodium_4-phenylbutyrate induces apoptosis of human lung_carcinoma cells through activating JNK pathway .
26399250	0	Sodium_Benzoate	0,15	Ciliary_Neurotrophic_Factor	75,102	Sodium Benzoate	Ciliary Neurotrophic Factor	MESH:D020160	12803(Tax:10090)	Chemical	Gene	Upregulates|nsubj|START_ENTITY Upregulates|dobj|END_ENTITY	Sodium_Benzoate , a Metabolite of Cinnamon and a Food Additive , Upregulates Ciliary_Neurotrophic_Factor in Astrocytes and Oligodendrocytes .
25686746	0	Sodium_Butyrate	0,15	HMGB1	97,102	Sodium Butyrate	HMGB1	CHEBI:64103	15289(Tax:10090)	Chemical	Gene	START_ENTITY|xcomp|Injuries Injuries|dep|Expression Expression|compound|END_ENTITY	Sodium_Butyrate Reduces Organ Injuries in Mice with Severe Acute Pancreatitis Through Inhibiting HMGB1 Expression .
24142577	0	Sodium_Glucose	0,14	SGLT2	38,43	Sodium Glucose	SGLT2	null	6524	Chemical	Gene	Type|compound|START_ENTITY Type|appos|END_ENTITY	Sodium_Glucose Co-transporter Type 2 -LRB- SGLT2 -RRB- Inhibitors : Targeting the Kidney to Improve Glycemic Control in Diabetes_Mellitus .
26999015	0	Sodium_Glucose	0,14	SGLT2	32,37	Sodium Glucose	SGLT2	null	64522(Tax:10116)	Chemical	Gene	Cotransporter|compound|START_ENTITY Cotransporter|appos|END_ENTITY	Sodium_Glucose Cotransporter 2 -LRB- SGLT2 -RRB- Plays as a Physiological Glucose Sensor and Regulates Cellular Contractility in Rat Mesangial Cells .
22627131	0	Sodium_arsenite	0,15	X-linked_inhibitor_of_apoptosis_protein	49,88	Sodium arsenite	X-linked inhibitor of apoptosis protein	MESH:C017947	331	Chemical	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|nmod|END_ENTITY	Sodium_arsenite down-regulates the expression of X-linked_inhibitor_of_apoptosis_protein via translational and post-translational mechanisms in hepatocellular_carcinoma .
23376440	0	Sodium_arsenite	0,15	cyclooxygenase-2	24,40	Sodium arsenite	cyclooxygenase-2	MESH:C017947	5743	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Sodium_arsenite induces cyclooxygenase-2 expression in human uroepithelial cells through MAPK pathway activation and reactive_oxygen_species induction .
18505831	0	Sodium_arsenite	0,15	nuclear_receptor_SHP	31,51	Sodium arsenite	nuclear receptor SHP	MESH:C017947	8431	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Sodium_arsenite induces orphan nuclear_receptor_SHP gene expression via AMP-activated protein kinase to inhibit gluconeogenic enzyme gene expression .
3139738	0	Sodium_aurothiomalate	0,21	interleukin-2	51,64	Sodium aurothiomalate	interleukin-2	MESH:D006052	16183(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Sodium_aurothiomalate inhibits T cell responses to interleukin-2 .
21701815	0	Sodium_benzoate	0,15	DJ-1	117,121	Sodium benzoate	DJ-1	MESH:D020160	11315	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	Sodium_benzoate , a metabolite of cinnamon and a food additive , upregulates neuroprotective Parkinson_disease protein DJ-1 in astrocytes and neurons .
17846062	0	Sodium_bicarbonate	0,18	semicarbazide-sensitive_amine_oxidase	61,98	Sodium bicarbonate	semicarbazide-sensitive amine oxidase	MESH:D017693	314	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|amod|END_ENTITY	Sodium_bicarbonate enhances membrane-bound and soluble human semicarbazide-sensitive_amine_oxidase activity in vitro .
16007142	0	Sodium_butyrate	0,15	Cdc2	96,100	Sodium butyrate	Cdc2	CHEBI:64103	983	Chemical	Gene	sensitizes|nsubj|START_ENTITY sensitizes|nmod|inhibition inhibition|nmod|END_ENTITY	Sodium_butyrate sensitizes human glioma cells to TRAIL-mediated apoptosis through inhibition of Cdc2 and the subsequent downregulation of survivin and XIAP .
17331472	0	Sodium_butyrate	0,15	ERK	26,29	Sodium butyrate	ERK	CHEBI:64103	5594	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Sodium_butyrate activates ERK to regulate differentiation of mesenchymal stem cells .
24709100	0	Sodium_butyrate	0,15	ERK	76,79	Sodium butyrate	ERK	CHEBI:64103	5594	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|modulating modulating|dobj|END_ENTITY	Sodium_butyrate induces apoptosis of human colon_cancer cells by modulating ERK and sphingosine_kinase_2 .
25332009	0	Sodium_butyrate	1,16	HMGB1	26,31	Sodium butyrate	HMGB1	CHEBI:64103	15289(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	-LSB- Sodium_butyrate inhibits HMGB1 expression and release and attenuates concanavalin A-induced acute liver_injury in mice -RSB- .
19139882	0	Sodium_butyrate	0,15	NKG2D	42,47	Sodium butyrate	NKG2D	CHEBI:64103	22914	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Sodium_butyrate upregulates expression of NKG2D ligand MICA/B in HeLa and HepG2 cell lines and increases their susceptibility to NK lysis .
19956429	0	Sodium_butyrate	0,15	Notch1	26,32	Sodium butyrate	Notch1	CHEBI:64103	25496(Tax:10116)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Sodium_butyrate activates Notch1 signaling , reduces tumor markers , and induces cell cycle arrest and apoptosis in pheochromocytoma .
10029297	0	Sodium_butyrate	0,15	alkaline_phosphatase	24,44	Sodium butyrate	alkaline phosphatase	CHEBI:64103	250	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Sodium_butyrate induces alkaline_phosphatase gene expression in human hepatoma cells .
17970072	0	Sodium_butyrate	0,15	androgen_receptor	26,43	Sodium butyrate	androgen receptor	CHEBI:64103	367	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Sodium_butyrate regulates androgen_receptor expression and cell cycle arrest in human prostate_cancer cells .
2261575	0	Sodium_butyrate	0,15	c-fos	46,51	Sodium butyrate	c-fos	CHEBI:64103	2353	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Sodium_butyrate inhibits c-myc and stimulates c-fos expression in all the steps of the cell-cycle in hepatoma tissue cultured cells .
2261575	0	Sodium_butyrate	0,15	c-myc	25,30	Sodium butyrate	c-myc	CHEBI:64103	4609	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Sodium_butyrate inhibits c-myc and stimulates c-fos expression in all the steps of the cell-cycle in hepatoma tissue cultured cells .
7767986	0	Sodium_butyrate	0,15	c-myc	25,30	Sodium butyrate	c-myc	CHEBI:64103	4609	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|splicing splicing|amod|END_ENTITY	Sodium_butyrate inhibits c-myc splicing and interferes with signal transduction in ovarian_carcinoma cells .
8376401	0	Sodium_butyrate	0,15	c-myc	85,90	Sodium butyrate	c-myc	CHEBI:64103	4609	Chemical	Gene	causes|nsubj|START_ENTITY causes|dobj|increase increase|nmod|block block|acl|transcriptional transcriptional|nmod|gene gene|amod|END_ENTITY	Sodium_butyrate causes an increase in the block to transcriptional elongation in the c-myc gene in SW837 rectal_carcinoma cells .
9738480	0	Sodium_butyrate	0,15	c-myc	97,102	Sodium butyrate	c-myc	CHEBI:64103	4609	Chemical	Gene	suppresses|amod|START_ENTITY apoptosis|nsubj|suppresses apoptosis|advcl|bearing bearing|dobj|translocations translocations|amod|END_ENTITY	Sodium_butyrate suppresses apoptosis in human Burkitt_lymphomas and murine plasmacytomas bearing c-myc translocations .
19863349	0	Sodium_butyrate	0,15	coxsackie_and_adenovirus_receptor	44,77	Sodium butyrate	coxsackie and adenovirus receptor	CHEBI:64103	1525	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Sodium_butyrate increases expression of the coxsackie_and_adenovirus_receptor in colon_cancer cells .
22338096	0	Sodium_butyrate	0,15	fibroblast_growth_factor_21	41,68	Sodium butyrate	fibroblast growth factor 21	CHEBI:64103	56636(Tax:10090)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|nmod|END_ENTITY	Sodium_butyrate stimulates expression of fibroblast_growth_factor_21 in liver by inhibition of histone_deacetylase_3 .
7196916	0	Sodium_butyrate	0,15	hCG	27,30	Sodium butyrate	hCG	CHEBI:64103	1081	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|compound|END_ENTITY	Sodium_butyrate stimulates hCG and hCG-alpha production in a human choriocarcinoma cell line -LRB- BeWo -RRB- .
15145607	0	Sodium_butyrate	0,15	interferon-gamma	27,43	Sodium butyrate	interferon-gamma	CHEBI:64103	15978(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|- -|amod|END_ENTITY	Sodium_butyrate suppresses interferon-gamma - , but not lipopolysaccharide-mediated induction of nitric_oxide and tumor necrosis factor-alpha in microglia .
23942267	0	Sodium_butyrate	0,15	interferon-gamma	25,41	Sodium butyrate	interferon-gamma	CHEBI:64103	3458	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Sodium_butyrate inhibits interferon-gamma induced indoleamine 2,3-dioxygenase expression via STAT1 in nasopharyngeal_carcinoma cells .
10757447	0	Sodium_butyrate	0,15	p53	26,29	Sodium butyrate	p53	CHEBI:64103	7157	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|compound|END_ENTITY	Sodium_butyrate modulates p53 and Bcl-2 expression in human retinoblastoma cell lines .
8102211	0	Sodium_butyrate	0,15	plasminogen_activator_inhibitor_type-1	41,79	Sodium butyrate	plasminogen activator inhibitor type-1	CHEBI:64103	5054	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Sodium_butyrate differentially modulates plasminogen_activator_inhibitor_type-1 , urokinase_plasminogen_activator , and its receptor in a human colon_carcinoma cell .
1555205	0	Sodium_butyrate	0,15	transforming_growth_factor-beta_1	76,109	Sodium butyrate	transforming growth factor-beta 1	CHEBI:64103	7040	Chemical	Gene	alters|nsubj|START_ENTITY alters|nmod|END_ENTITY	Sodium_butyrate alters the response of a human colon_carcinoma cell line to transforming_growth_factor-beta_1 .
1204570	0	Sodium_chloride	0,15	renin	31,36	Sodium chloride	renin	MESH:D012965	24715(Tax:10116)	Chemical	Gene	suppression|amod|START_ENTITY suppression|nmod|END_ENTITY	Sodium_chloride suppression of renin release in the unanesthetized rat .
24681588	0	Sodium_fluoride	0,15	ERK	26,29	Sodium fluoride	ERK	MESH:D012969	24338(Tax:10116)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Sodium_fluoride activates ERK and JNK via induction of oxidative stress to promote apoptosis and impairs ovarian function in rats .
24030355	0	Sodium_fluoride	0,15	H19	44,47	Sodium fluoride	H19	MESH:D012969	14955(Tax:10090)	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	Sodium_fluoride disrupts DNA methylation of H19 and Peg3 imprinted genes during the early development of mouse embryo .
24196489	0	Sodium_fluoride	0,15	MMP-2	25,30	Sodium fluoride	MMP-2	MESH:D012969	4313	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Sodium_fluoride inhibits MMP-2 and MMP-9 .
26647781	0	Sodium_orthovanadate	0,20	PIWIL2	74,80	Sodium orthovanadate	PIWIL2	null	55124	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|inhibiting inhibiting|dobj|END_ENTITY	Sodium_orthovanadate induces the apoptosis of SH-SY5Y cells by inhibiting PIWIL2 .
16875784	0	Sodium_orthovanadate	0,20	nitric_oxide_synthase	66,87	Sodium orthovanadate	nitric oxide synthase	null	4843	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Sodium_orthovanadate induced tyrosine phosphorylation of platelet nitric_oxide_synthase negatively regulates enzyme activity .
21148631	0	Sodium_oxybate	0,14	prolactin	25,34	Sodium oxybate	prolactin	MESH:D012978	5617	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|secretion secretion|compound|END_ENTITY	Sodium_oxybate increases prolactin secretion in narcolepsy patients and healthy controls .
17373676	0	Sodium_phenyl_butyrate	0,22	endothelin-1	37,49	Sodium phenyl butyrate	endothelin-1	null	1906	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	Sodium_phenyl_butyrate downregulates endothelin-1 expression in cultured human endothelial cells : relevance to sickle-cell_disease .
12934647	0	Sodium_salicylate	0,17	COX-2	41,46	Sodium salicylate	COX-2	MESH:D012980	29527(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Sodium_salicylate inhibits expression of COX-2 through suppression of ERK and subsequent NF-kappaB activation in rat ventricular cardiomyocytes .
10962002	0	Sodium_salicylate	0,17	FKBP51	61,67	Sodium salicylate	FKBP51	MESH:D012980	14229(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Sodium_salicylate induces the expression of the immunophilin FKBP51 and biglycan genes and inhibits p34cdc2 mRNA both in vitro and in vivo .
16432451	0	Sodium_salicylate	0,17	NF-kappaB	45,54	Sodium salicylate	NF-kappaB	MESH:D012980	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	Sodium_salicylate inhibits TNF-alpha-induced NF-kappaB activation , cell migration , invasion and ICAM-1 expression in human melanoma cells .
10357911	0	Sodium_salicylate	0,17	TNF-alpha	38,47	Sodium salicylate	TNF-alpha	MESH:D012980	24835(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Sodium_salicylate inhibits macrophage TNF-alpha production and alters MAPK activation .
9187256	0	Sodium_salicylate	0,17	cyclo-oxygenase-2	27,44	Sodium salicylate	cyclo-oxygenase-2	MESH:D012980	5743	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Sodium_salicylate inhibits cyclo-oxygenase-2 activity independently of transcription factor -LRB- nuclear factor kappaB -RRB- activation : role of arachidonic_acid .
18547722	0	Sodium_selenite	0,15	ERK	72,75	Sodium selenite	ERK	MESH:D018038	5594	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|activation activation|nmod|END_ENTITY	Sodium_selenite inhibits gamma-secretase activity through activation of ERK .
19811770	0	Sodium_selenite	0,15	VEGF	43,47	Sodium selenite	VEGF	MESH:D018038	7422	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Sodium_selenite inhibits the expression of VEGF , TGFbeta -LRB- 1 -RRB- and IL-6 induced by LPS in human PC3 cells via TLR4-NF - -LRB- K -RRB- B signaling blockage .
17346688	0	Sodium_selenite	0,15	androgen_receptor	48,65	Sodium selenite	androgen receptor	MESH:D018038	367	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|compound|END_ENTITY	Sodium_selenite inhibits interleukin-6-mediated androgen_receptor activation in prostate_cancer cells via upregulation of c-Jun .
16272361	0	Sodium_stibogluconate	0,21	IL-2	37,41	Sodium stibogluconate	IL-2	MESH:D000967	16183(Tax:10090)	Chemical	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Sodium_stibogluconate interacts with IL-2 in anti-Renca_tumor action via a T cell-dependent mechanism in connection with induction of tumor-infiltrating macrophages .
24867799	0	Sodium_taurocholate	0,19	SLC10A1	48,55	Sodium taurocholate	SLC10A1	MESH:D013656	6554	Chemical	Gene	polypeptide|amod|START_ENTITY polypeptide|appos|END_ENTITY	Sodium_taurocholate cotransporting polypeptide -LRB- SLC10A1 -RRB- deficiency : conjugated hypercholanemia without a clear clinical phenotype .
22290468	0	Sodium_valproate	0,16	NM23H1	82,88	Sodium valproate	NM23H1	MESH:D014635	4830	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|upregulating upregulating|dobj|expression expression|compound|END_ENTITY	Sodium_valproate inhibits MDA-MB-231 breast_cancer cell migration by upregulating NM23H1 expression .
10700573	0	Sodium_valproate	0,16	TNF-alpha	40,49	Sodium valproate	TNF-alpha	MESH:D014635	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|nmod|END_ENTITY	Sodium_valproate inhibits production of TNF-alpha and IL-6 and activation of NF-kappaB .
9536026	0	Sodium_valproate	0,16	myristoylated_alanine-rich_C_kinase_substrate	36,81	Sodium valproate	myristoylated alanine-rich C kinase substrate	MESH:D014635	4082	Chemical	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|END_ENTITY	Sodium_valproate down-regulates the myristoylated_alanine-rich_C_kinase_substrate -LRB- MARCKS -RRB- in immortalized hippocampal cells : a property of protein kinase C-mediated mood stabilizers .
20599750	0	Sofalcone	0,9	vascular_endothelial_growth_factor	56,90	Sofalcone	vascular endothelial growth factor	MESH:C035032	83785(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Sofalcone , a gastric mucosa protective agent , increases vascular_endothelial_growth_factor via the Nrf2-heme-oxygenase-1 dependent pathway in gastric epithelial cells .
24965900	0	Sofinicline	0,11	nicotinic_acetylcholine_receptor	21,53	Sofinicline	nicotinic acetylcholine receptor	null	1137	Chemical	Gene	START_ENTITY|dep|agonist agonist|compound|END_ENTITY	Sofinicline : a novel nicotinic_acetylcholine_receptor agonist in the treatment of attention-deficit/hyperactivity _ disorder .
18078328	0	Solamargine	0,11	HER2	21,25	Solamargine	HER2	MESH:C026609	2064	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	Solamargine enhances HER2 expression and increases the susceptibility of human lung_cancer H661 and H69 cells to trastuzumab and epirubicin .
26362598	0	Solanocapsine	0,13	acetylcholinesterase	53,73	Solanocapsine	acetylcholinesterase	null	43	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|inhibitors inhibitors|nmod|END_ENTITY	Solanocapsine derivatives as potential inhibitors of acetylcholinesterase : Synthesis , molecular docking and biological studies .
24368568	0	Solomonsterol_A	0,15	pregnane-X-receptor	26,45	Solomonsterol A	pregnane-X-receptor	MESH:C561233	18171(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Solomonsterol_A , a marine pregnane-X-receptor agonist , attenuates_inflammation and immune_dysfunction in a mouse model of arthritis .
1859449	0	Soman	0,5	acetylcholinesterase	49,69	Soman	acetylcholinesterase	MESH:D012999	11423(Tax:10090)	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	Soman and sarin inhibition of molecular forms of acetylcholinesterase in mice .
7517637	0	Somatostatin	0,12	CCK	22,25	Somatostatin	CCK	MESH:D013004	25298(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|compound|END_ENTITY	Somatostatin inhibits CCK release by inhibiting secretion and action of CCK-releasing peptide .
7911992	0	Somatostatin	0,12	CCK	80,83	Somatostatin	CCK	MESH:D013004	609547(Tax:9615)	Chemical	Gene	released|nsubjpass|START_ENTITY released|xcomp|cholecystokinin cholecystokinin|dobj|receptors receptors|compound|END_ENTITY	Somatostatin is released in response to cholecystokinin by activation of type A CCK receptors .
1975739	0	Somatostatin	0,12	Ca2	27,30	Somatostatin	Ca2	MESH:D013004	760	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	Somatostatin inhibition of Ca2 -LRB- + -RRB- - induced insulin secretion in permeabilized HIT-T15 cells .
7500129	0	Somatostatin	0,12	Ca2	46,49	Somatostatin	Ca2	MESH:D013004	54231(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|channels channels|amod|END_ENTITY	Somatostatin modulates high-voltage-activated Ca2 + channels in freshly dissociated rat hippocampal neurons .
25068602	0	Somatostatin	13,25	Filamin_A	0,9	Somatostatin	Filamin A	MESH:D013004	2316	Chemical	Gene	Regulation|compound|START_ENTITY END_ENTITY|nmod|Regulation	Filamin_A in Somatostatin and Dopamine Receptor Regulation in Pituitary and the Role of cAMP/PKA Dependent Phosphorylation .
27072430	0	Somatostatin	0,12	GHRH	65,69	Somatostatin	GHRH	MESH:D013004	14601(Tax:10090)	Chemical	Gene	triggers|nsubj|START_ENTITY triggers|dobj|firing firing|nmod|neurons neurons|compound|END_ENTITY	Somatostatin triggers rhythmic electrical firing in hypothalamic GHRH neurons .
8793889	0	Somatostatin	0,12	GHRH	116,120	Somatostatin	GHRH	MESH:D013004	485863(Tax:9615)	Chemical	Gene	withdrawal|compound|START_ENTITY withdrawal|dep|tool tool|acl|evaluate evaluate|dobj|tone tone|compound|END_ENTITY	Somatostatin withdrawal as generator of pulsatile GH release in the dog : a possible tool to evaluate the endogenous GHRH tone ?
9407314	0	Somatostatin	0,12	IL-2	39,43	Somatostatin	IL-2	MESH:D013004	3558	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|secretion secretion|compound|END_ENTITY	Somatostatin increases mitogen-induced IL-2 secretion and proliferation of human Jurkat T cells via sst3 receptor isotype .
8684611	0	Somatostatin	0,12	SSTR2	31,36	Somatostatin	SSTR2	MESH:D013004	20606(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY subtypes|nsubj|receptor subtypes|dobj|couple couple|compound|END_ENTITY	Somatostatin receptor subtypes SSTR2 and SSTR5 couple negatively to an L-type Ca2 + current in the pituitary cell line AtT-20 .
1357581	0	Somatostatin	0,12	VIP	27,30	Somatostatin	VIP	MESH:D013004	117064(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|inhibition inhibition|nmod|END_ENTITY	Somatostatin inhibition of VIP - and isoproterenol-stimulated cyclic_AMP production in rat peritoneal macrophages .
1364040	0	Somatostatin	0,12	VIP	22,25	Somatostatin	VIP	MESH:D013004	117064(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Somatostatin inhibits VIP - and forskolin-stimulated cyclic_AMP accumulation in enterocytes from rat jejunum .
7576950	0	Somatostatin	0,12	VIP	48,51	Somatostatin	VIP	MESH:D013004	7432	Chemical	Gene	peptide|amod|START_ENTITY peptide|appos|END_ENTITY	Somatostatin and vasoactive intestinal peptide -LRB- VIP -RRB- in neuroblastoma and ganglioneuroma : chromatographic characterisation and release during surgery .
6114434	0	Somatostatin	0,12	angiotensin_II	34,48	Somatostatin	angiotensin II	MESH:D013004	183	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|effects effects|nmod|END_ENTITY	Somatostatin modulates effects of angiotensin_II in adrenal glomerulosa zone .
2878746	0	Somatostatin	0,12	beta-endorphin	63,77	Somatostatin	beta-endorphin	MESH:D013004	5443	Chemical	Gene	infusion|compound|START_ENTITY inhibits|nsubj|infusion inhibits|dobj|rise rise|amod|END_ENTITY	Somatostatin and oxytocin infusion inhibits the rise of plasma beta-endorphin , beta-lipotrophin and cortisol induced by insulin hypoglycaemia .
10322947	0	Somatostatin	1,13	c-fos	47,52	Somatostatin	c-fos	MESH:D013004	314322(Tax:10116)	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|dobj|expression expression|amod|END_ENTITY	-LSB- Somatostatin and electroacupuncture inhibited c-fos expression in spinal cord of arthritic rats -RSB- .
15142533	0	Somatostatin	0,12	calcitonin_gene-related_peptide	15,46	Somatostatin	calcitonin gene-related peptide	MESH:D013004	796	Chemical	Gene	-|compound|START_ENTITY -|appos|END_ENTITY	Somatostatin - , calcitonin_gene-related_peptide , and gamma-aminobutyric_acid-like immunoreactivitity in the frog lumbosacral spinal cord : distribution and effects of sciatic nerve transection .
1969232	0	Somatostatin	0,12	cholecystokinin	32,47	Somatostatin	cholecystokinin	MESH:D013004	25298(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Somatostatin regulates duodenal cholecystokinin and somatostatin messenger RNA .
1362042	0	Somatostatin	0,12	gastrin	26,33	Somatostatin	gastrin	MESH:D013004	445524(Tax:9823)	Chemical	Gene	restraint|compound|START_ENTITY restraint|nmod|secretion secretion|compound|END_ENTITY	Somatostatin restraint of gastrin secretion in pigs revealed by monoclonal antibody immunoneutralization .
6114896	0	Somatostatin	0,12	gastrin	58,65	Somatostatin	gastrin	MESH:D013004	25320(Tax:10116)	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|release release|compound|END_ENTITY	Somatostatin inhibition of basal and carbachol-stimulated gastrin release in rat antral organ culture .
785589	0	Somatostatin	0,12	gastrin	41,48	Somatostatin	gastrin	MESH:D013004	2520	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|compound|END_ENTITY	Somatostatin inhibits insulin-stimulated gastrin release and gastric secretion of acid , pepsin , and intrinsic_factor -LRB- IF -RRB- in duodenal ulcer patients .
8831586	0	Somatostatin	0,12	gastrin	55,62	Somatostatin	gastrin	MESH:D013004	2520	Chemical	Gene	receptor|compound|START_ENTITY subtype|nsubj|receptor subtype|dobj|inhibition inhibition|nmod|secretion secretion|compound|END_ENTITY	Somatostatin receptor subtype 2 mediates inhibition of gastrin and histamine secretion from human , dog , and rat antrum .
10622746	0	Somatostatin	0,12	growth_hormone	62,76	Somatostatin	growth hormone	MESH:D013004	14599(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY subtype|nsubj|receptor subtype|dobj|inhibition inhibition|nmod|release release|amod|END_ENTITY	Somatostatin receptor subtype 1 modulates basal inhibition of growth_hormone release in somatotrophs .
11325529	0	Somatostatin	0,12	growth_hormone	53,67	Somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	actions|compound|START_ENTITY END_ENTITY|nsubj|actions	Somatostatin actions on a protein kinase C-dependent growth_hormone secretagogue cascade .
22129035	0	Somatostatin	0,12	growth_hormone	37,51	Somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|amod|END_ENTITY	Somatostatin dramatically stimulates growth_hormone release from primate somatotrophs acting at low doses via somatostatin_receptor_5 and cyclic_AMP .
2572506	0	Somatostatin	0,12	growth_hormone	102,116	Somatostatin	growth hormone	MESH:D013004	378781(Tax:9031)	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|secretion secretion|amod|END_ENTITY	Somatostatin inhibition of thyrotropin-releasing_hormone - and growth_hormone-releasing factor-induced growth_hormone secretion in young and adult anesthetized chickens .
2573509	0	Somatostatin	0,12	growth_hormone	27,41	Somatostatin	growth hormone	MESH:D013004	81668(Tax:10116)	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|secretion secretion|amod|END_ENTITY	Somatostatin inhibition of growth_hormone secretion by somatotropes from male , female , and androgen_receptor-deficient rats : evidence for differing sensitivities .
2859538	0	Somatostatin	0,12	growth_hormone	124,138	Somatostatin	growth hormone	MESH:D013004	81668(Tax:10116)	Chemical	Gene	release|nsubj|START_ENTITY release|parataxis|suppressed suppressed|dobj|secretion secretion|amod|END_ENTITY	Somatostatin release from the median eminence of unanesthetized rats : lack of correlation with pharmacologically suppressed growth_hormone secretion .
2885213	0	Somatostatin	0,12	growth_hormone	97,111	Somatostatin	growth hormone	MESH:D013004	378781(Tax:9031)	Chemical	Gene	immunoneutralization|compound|START_ENTITY overcomes|nsubj|immunoneutralization overcomes|nmod|secretion secretion|amod|END_ENTITY	Somatostatin immunoneutralization overcomes the inhibitory effects of quipazine and pargyline on growth_hormone secretion in domestic fowl .
2886273	0	Somatostatin	0,12	growth_hormone	27,41	Somatostatin	growth hormone	MESH:D013004	378781(Tax:9031)	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|secretion secretion|amod|END_ENTITY	Somatostatin inhibition of growth_hormone secretion in an adult bird : the domestic fowl .
2897284	0	Somatostatin	0,12	growth_hormone	34,48	Somatostatin	growth hormone	MESH:D013004	81668(Tax:10116)	Chemical	Gene	restores|nsubj|START_ENTITY restores|dobj|END_ENTITY	Somatostatin rapidly restores rat growth_hormone -LRB- GH -RRB- release response attenuated by prior exposure to human GH-releasing factor in vitro .
499752	0	Somatostatin	0,12	growth_hormone	35,49	Somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	inhibition|compound|START_ENTITY END_ENTITY|nsubj|inhibition	Somatostatin inhibition of teleost growth_hormone secretion .
744118	0	Somatostatin	0,12	growth_hormone	119,133	Somatostatin	growth hormone	MESH:D013004	81668(Tax:10116)	Chemical	Gene	content|compound|START_ENTITY content|nmod|control control|nmod|secretion secretion|amod|END_ENTITY	Somatostatin content of the median eminence in female rats with lesion-induced disruption of the inhibitory control of growth_hormone secretion .
8675565	0	Somatostatin	0,12	growth_hormone	35,49	Somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	pretreatment|compound|START_ENTITY enhances|nsubj|pretreatment enhances|dobj|responsiveness responsiveness|amod|END_ENTITY	Somatostatin pretreatment enhances growth_hormone -LRB- GH -RRB- responsiveness to GH-releasing hormone : a potential new diagnostic approach to GH_deficiency .
9410919	0	Somatostatin	0,12	growth_hormone	90,104	Somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	receptor|compound|START_ENTITY analogues|nsubj|receptor analogues|xcomp|suppress suppress|advcl|END_ENTITY	Somatostatin receptor -LRB- SSTR -RRB- subtype-selective analogues differentially suppress in vitro growth_hormone and prolactin in human pituitary_adenomas .
9623629	0	Somatostatin	0,12	growth_hormone	37,51	Somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|amod|END_ENTITY	Somatostatin at low doses stimulates growth_hormone release from intact cultures of porcine pituitary cells .
2880921	0	Somatostatin	0,12	growth_hormone-releasing_factor	75,106	Somatostatin	growth hormone-releasing factor	MESH:D013004	29446(Tax:10116)	Chemical	Gene	reverses|nsubj|START_ENTITY reverses|dobj|desensitization desensitization|nmod|somatotrophs somatotrophs|acl|induced induced|nmod|END_ENTITY	Somatostatin partially reverses desensitization of somatotrophs induced by growth_hormone-releasing_factor .
2884644	0	Somatostatin	0,12	growth_hormone-releasing_factor	50,81	Somatostatin	growth hormone-releasing factor	MESH:D013004	29446(Tax:10116)	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|dobj|action action|nmod|END_ENTITY	Somatostatin prevents the desensitizing action of growth_hormone-releasing_factor on growth hormone release .
371865	0	Somatostatin	1,13	growth_hormone-releasing_factor	64,95	Somatostatin	growth hormone-releasing factor	MESH:D013004	2691	Chemical	Gene	START_ENTITY|dep|comparison comparison|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Somatostatin in the human cerebrospinal fluid -- comparison with growth_hormone-releasing_factor -RSB- .
11408783	0	Somatostatin	0,12	growth_hormone-releasing_hormone	62,94	Somatostatin	growth hormone-releasing hormone	MESH:D013004	281191(Tax:9913)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|nmod|END_ENTITY	Somatostatin inhibits alpha-2-adrenergic-induced secretion of growth_hormone-releasing_hormone .
874045	0	Somatostatin	0,12	insulin	48,55	Somatostatin	insulin	MESH:D013004	3630	Chemical	Gene	modulation|compound|START_ENTITY modulation|appos|fatty_acids fatty_acids|compound|glucose glucose|compound|END_ENTITY	Somatostatin modulation of pancreatic glucagon , insulin , glucose and free fatty_acids following beta-adrenergic stimulation .
17880945	0	Somatostatin	0,12	insulin-like_growth_factor-I	22,50	Somatostatin	insulin-like growth factor-I	MESH:D013004	100136741(Tax:8022)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Somatostatin inhibits insulin-like_growth_factor-I receptor expression in the gill of a teleost fish -LRB- Oncorhynchus_mykiss -RRB- .
15316244	0	Somatostatin	0,12	interleukin-6	90,103	Somatostatin	interleukin-6	MESH:D013004	24498(Tax:10116)	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|release release|nmod|cells cells|amod|END_ENTITY	Somatostatin and gamma-aminobutyric_acid inhibit interleukin-1_beta-stimulated release of interleukin-6 from rat C6 glioma cells .
2875480	0	Somatostatin	0,12	prolactin	31,40	Somatostatin	prolactin	MESH:D013004	5617	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Somatostatin and regulation of prolactin secretion .
2906508	0	Somatostatin	0,12	prolactin	22,31	Somatostatin	prolactin	MESH:D013004	24683(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|compound|END_ENTITY	Somatostatin inhibits prolactin secretion by multiple mechanisms involving a site of action distal to increased cyclic_adenosine_3 ' ,5 ' - monophosphate and elevated cytosolic Ca2 + in rat lactotrophs .
6119146	0	Somatostatin	0,12	prolactin	22,31	Somatostatin	prolactin	MESH:D013004	24683(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|compound|END_ENTITY	Somatostatin inhibits prolactin secretion in the estradiol primed male rat .
9892010	0	Somatostatin	0,12	somatostatin_receptor_1	64,87	Somatostatin	somatostatin receptor 1	MESH:D013004	6751	Chemical	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Somatostatin activation of mitogen-activated_protein kinase via somatostatin_receptor_1 -LRB- SSTR1 -RRB- .
9753128	0	Somatostatin	0,12	sst1	31,35	Somatostatin	sst1	MESH:D013004	112256(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY subtypes|nsubj|receptor subtypes|ccomp|elicit elicit|nsubj|END_ENTITY	Somatostatin receptor subtypes sst1 and sst2 elicit opposite effects on the response to glutamate of mouse hypothalamic neurones : an electrophysiological and single cell RT-PCR study .
12878607	0	Somatostatin	5,17	sst2	0,4	Somatostatin	sst2	MESH:D013004	20606(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|nummod|END_ENTITY	sst2 Somatostatin receptor inhibits cell proliferation through Ras - , Rap1 - , and B-Raf-dependent ERK2 activation .
14975694	0	Somatostatin	0,12	sst2	101,105	Somatostatin	sst2	MESH:D013004	20606(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|receptors receptors|amod|END_ENTITY	Somatostatin inhibits glutamate release from mouse cerebrocortical nerve endings through presynaptic sst2 receptors linked to the adenylyl cyclase-protein kinase A pathway .
9052751	0	Somatostatin	0,12	sst3	43,47	Somatostatin	sst3	MESH:D013004	25992	Chemical	Gene	receptor|nsubj|START_ENTITY receptor|dobj|expression expression|amod|subtypes subtypes|dep|sst1 sst1|nummod|END_ENTITY	Somatostatin receptor subtypes sst1 , sst2 , sst3 and sst5 expression in human pituitary , _ gastroentero-pancreatic_and_mammary_tumors : comparison of mRNA analysis with receptor autoradiography .
9407314	0	Somatostatin	0,12	sst3	100,104	Somatostatin	sst3	MESH:D013004	25992	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|secretion secretion|nmod|isotype isotype|amod|END_ENTITY	Somatostatin increases mitogen-induced IL-2 secretion and proliferation of human Jurkat T cells via sst3 receptor isotype .
11717135	0	Somatostatin	0,12	stem_cell_factor	22,38	Somatostatin	stem cell factor	MESH:D013004	4254	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Somatostatin inhibits stem_cell_factor messenger RNA expression by Sertoli cells and stem_cell_factor-induced DNA synthesis in isolated seminiferous tubules .
2572506	0	Somatostatin	0,12	thyrotropin-releasing_hormone	27,56	Somatostatin	thyrotropin-releasing hormone	MESH:D013004	414344(Tax:9031)	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|secretion secretion|amod|END_ENTITY	Somatostatin inhibition of thyrotropin-releasing_hormone - and growth_hormone-releasing factor-induced growth_hormone secretion in young and adult anesthetized chickens .
100786	0	Somatostatin	0,12	thyrotropin_releasing_factor	33,61	Somatostatin	thyrotropin releasing factor	MESH:D013004	25569(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|nmod|END_ENTITY	Somatostatin inhibits release of thyrotropin_releasing_factor from organ cultures of rat hypothalamus .
24587659	0	Sophocarpine	0,12	TLR4	57,61	Sophocarpine	TLR4	MESH:C035933	29260(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|advcl|inhibiting inhibiting|dobj|END_ENTITY	Sophocarpine attenuates liver fibrosis by inhibiting the TLR4 signaling pathway in rats .
10418325	0	Sophoricoside	0,13	IL-5	29,33	Sophoricoside	IL-5	MESH:C120642	3567	Chemical	Gene	analogs|amod|START_ENTITY analogs|nmod|END_ENTITY	Sophoricoside analogs as the IL-5 inhibitors from Sophora japonica .
26381511	0	Sorafenib	31,40	Akt	55,58	Sorafenib	Akt	MESH:C471405	207	Chemical	Gene	START_ENTITY|nmod|Activation Activation|compound|END_ENTITY	Bufalin Reverses Resistance to Sorafenib by Inhibiting Akt Activation in Hepatocellular_Carcinoma : The Role of Endoplasmic Reticulum Stress .
19638574	0	Sorafenib	0,9	B-RAF	71,76	Sorafenib	B-RAF	MESH:C471405	673	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	Sorafenib inhibits non-small_cell_lung_cancer cell growth by targeting B-RAF in KRAS wild-type cells and C-RAF in KRAS mutant cells .
20682655	0	Sorafenib	0,9	CD95	20,24	Sorafenib	CD95	MESH:C471405	355	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Sorafenib activates CD95 and promotes autophagy and cell death via Src family kinases in gastrointestinal_tumor cells .
20810616	0	Sorafenib	0,9	ERK	34,37	Sorafenib	ERK	MESH:C471405	5594	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|compound|END_ENTITY	Sorafenib inhibits cAMP-dependent ERK activation , cell proliferation , and in vitro cyst growth of human ADPKD cyst epithelial cells .
20038816	0	Sorafenib	0,9	ERK1/2	19,25	Sorafenib	ERK1/2	MESH:C471405	5595;5594	Chemical	Gene	inhibits|dep|START_ENTITY inhibits|nsubj|END_ENTITY	Sorafenib inhibits ERK1/2 and MCL-1 -LRB- L -RRB- phosphorylation levels resulting in caspase-independent cell death in malignant pleural_mesothelioma .
25964636	0	Sorafenib	0,9	FMS-Like_Receptor_Tyrosine_Kinase-3	31,66	Sorafenib	FMS-Like Receptor Tyrosine Kinase-3	MESH:C471405	2322	Chemical	Gene	START_ENTITY|nmod|Mutation Mutation|compound|END_ENTITY	Sorafenib in Relapsed_AML With FMS-Like_Receptor_Tyrosine_Kinase-3 Internal Tandem Duplication Mutation .
22922424	0	Sorafenib	0,9	HTATIP2	39,46	Sorafenib	HTATIP2	MESH:C471405	53415(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|expression expression|nmod|END_ENTITY	Sorafenib down-regulates expression of HTATIP2 to promote invasiveness and metastasis of orthotopic hepatocellular_carcinoma tumors in mice .
22773582	0	Sorafenib	0,9	MMP-9	31,36	Sorafenib	MMP-9	MESH:C471405	4318	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Sorafenib inhibits TPA-induced MMP-9 and VEGF expression via suppression of ERK/NF-kB pathway in hepatocellular_carcinoma cells .
21293487	0	Sorafenib	0,9	Mcl-1	96,101	Sorafenib	Mcl-1	MESH:C471405	4170	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|downregulation downregulation|nmod|END_ENTITY	Sorafenib induces cell death in chronic_lymphocytic_leukemia by translational downregulation of Mcl-1 .
22188816	0	Sorafenib	0,9	Mcl-1	111,116	Sorafenib	Mcl-1	MESH:C471405	4170	Chemical	Gene	sensitizes|amod|START_ENTITY sensitizes|dep|suppression suppression|nmod|cells cells|nmod|inhibition inhibition|compound|END_ENTITY	Sorafenib sensitizes -LRB- - -RRB- - gossypol-induced growth suppression in androgen-independent prostate_cancer cells via Mcl-1 inhibition and Bak activation .
23154882	0	Sorafenib	0,9	Mcl-1	66,71	Sorafenib	Mcl-1	MESH:C471405	4170	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Sorafenib inhibits in vitro osteoclastogenesis by down-modulating Mcl-1 .
23463670	0	Sorafenib	0,9	Mcl-1	80,85	Sorafenib	Mcl-1	MESH:C471405	4170	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|inhibiting inhibiting|dobj|transcription transcription|amod|END_ENTITY	Sorafenib induces endometrial_carcinoma apoptosis by inhibiting Elk-1-dependent Mcl-1 transcription and inducing Akt/GSK3b-dependent protein degradation .
26459180	0	Sorafenib	0,9	Mcl-1	24,29	Sorafenib	Mcl-1	MESH:C471405	4170	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Sorafenib inhibition of Mcl-1 accelerates ATRA induced apoptosis in differentiation responsive AML cells .
26603262	0	Sorafenib	34,43	Mcl-1	97,102	Sorafenib	Mcl-1	MESH:C471405	4170	Chemical	Gene	Resistance|compound|START_ENTITY Overcome|dobj|Resistance Overcome|nmod|Suppression Suppression|compound|END_ENTITY	Cyclin_E1 Inhibition Can Overcome Sorafenib Resistance in Hepatocellular_Carcinoma Cells Through Mcl-1 Suppression .
20197401	0	Sorafenib	0,9	STAT3	19,24	Sorafenib	STAT3	MESH:C471405	6774	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|compound|END_ENTITY	Sorafenib inhibits STAT3 activation to enhance TRAIL-mediated apoptosis in human pancreatic_cancer cells .
23474115	0	Sorafenib	0,9	STAT3	89,94	Sorafenib	STAT3	MESH:C471405	6774	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|advcl|inhibiting inhibiting|dobj|END_ENTITY	Sorafenib enhances radiation-induced apoptosis in hepatocellular_carcinoma by inhibiting STAT3 .
20071162	0	Sorafenib	26,35	TRAIL	97,102	Sorafenib	TRAIL	MESH:C471405	8743	Chemical	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	The multikinase inhibitor Sorafenib induces apoptosis and sensitises endometrial_cancer cells to TRAIL by different mechanisms .
20884624	0	Sorafenib	0,9	TRAIL	20,25	Sorafenib	TRAIL	MESH:C471405	22035(Tax:10090)	Chemical	Gene	overcomes|nsubj|START_ENTITY overcomes|dobj|resistance resistance|amod|END_ENTITY	Sorafenib overcomes TRAIL resistance of hepatocellular_carcinoma cells through the inhibition of STAT3 .
23674352	0	Sorafenib	0,9	TRAIL	45,50	Sorafenib	TRAIL	MESH:C471405	8743	Chemical	Gene	inhibitors|nsubj|START_ENTITY inhibitors|xcomp|synergize synergize|nmod|END_ENTITY	Sorafenib and HDAC inhibitors synergize with TRAIL to kill tumor cells .
22307138	0	Sorafenib	0,9	UGT1A1	29,35	Sorafenib	UGT1A1	MESH:C471405	54658	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Sorafenib is an inhibitor of UGT1A1 but is metabolized by UGT1A9 : implications of genetic variants on pharmacokinetics and hyperbilirubinemia .
20962354	0	Sorafenib	0,9	VEGF	95,99	Sorafenib	VEGF	MESH:C471405	7422	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|dobj|cells cells|nmod|overexpression overexpression|nmod|END_ENTITY	Sorafenib prevents human retinal pigment epithelium cells from light-induced overexpression of VEGF , PDGF and PlGF .
26476711	0	Sorafenib	75,84	VEGF	20,24	Sorafenib	VEGF	MESH:C471405	7422	Chemical	Gene	Treated|nmod|START_ENTITY END_ENTITY|nmod|Treated	Prognostic Value of VEGF in Hepatocellular_Carcinoma Patients Treated with Sorafenib : A Meta-Analysis .
16988583	3	Sorafenib	254,263	VEGFR	423,428	Sorafenib	PDGFR	MESH:C471405	5159	Chemical	Gene	developed|nsubjpass|START_ENTITY developed|parataxis|has has|dobj|activity activity|nmod|END_ENTITY	RECENT FINDINGS : Sorafenib was initially developed as an inhibitor of Raf kinase ; however , it has broad spectrum activity against multiple tyrosine kinases , including angiogenic factors VEGFR and PDGFR .
27030639	0	Sorafenib	49,58	VEGFR	32,37	Sorafenib	VEGFR	MESH:C471405	3791	Chemical	Gene	Inhibitor|appos|START_ENTITY Inhibitor|compound|END_ENTITY	Combination Targeted Therapy of VEGFR Inhibitor , Sorafenib , with an mTOR inhibitor , Sirolimus Induced a Remakable Response of Rapid progressive Uterine PEComa .
26723100	0	Sorafenib	102,111	Vascular_Endothelial_Growth_Factor_Receptor	33,76	Sorafenib	Vascular Endothelial Growth Factor Receptor	MESH:C471405	3791	Chemical	Gene	Inhibitors|nmod|START_ENTITY Inhibitors|compound|END_ENTITY	Efficacy and Safety of Selective Vascular_Endothelial_Growth_Factor_Receptor Inhibitors Compared with Sorafenib for Metastatic_Renal_Cell_Carcinoma : a Meta-analysis of Randomised Controlled Trials .
25895026	0	Sorafenib	0,9	c-Met	29,34	Sorafenib	c-Met	MESH:C471405	4233	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Sorafenib and DE605 , a novel c-Met inhibitor , synergistically suppress hepatocellular_carcinoma .
21601561	0	Sorafenib	0,9	mammalian_target_of_rapamycin	100,129	Sorafenib	mammalian target of rapamycin	MESH:C471405	2475	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Sorafenib induces apoptotic cell death in human non-small cell lung_cancer cells by down-regulating mammalian_target_of_rapamycin -LRB- mTOR -RRB- - dependent survivin expression .
19447162	0	Sorafenib	0,9	nuclear_factor_kappa_B	19,41	Sorafenib	nuclear factor kappa B	MESH:C471405	18033(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Sorafenib inhibits nuclear_factor_kappa_B , decreases inducible nitric_oxide synthase and cyclooxygenase-2 expression , and restores working memory in APPswe mice .
21878748	0	Sorafenib	0,9	p21	21,24	Sorafenib	p21	MESH:C471405	644914	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|END_ENTITY	Sorafenib attenuates p21 in kidney_cancer cells and augments cell death in combination with DNA-damaging chemotherapy .
19821497	0	Sorafenib	0,9	signal_transducer_and_activator_of_transcription-3	19,69	Sorafenib	signal transducer and activator of transcription-3	MESH:C471405	6774	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Sorafenib inhibits signal_transducer_and_activator_of_transcription-3 signaling in cholangiocarcinoma cells by activating the phosphatase shatterproof 2 .
24121631	0	Sortilin	0,8	APOE	18,22	Sortilin	APOE	null	11816(Tax:10090)	Chemical	Gene	START_ENTITY|appos|receptor receptor|compound|END_ENTITY	Sortilin , a novel APOE receptor implicated in Alzheimer_disease .
18687776	0	Sortilin	0,8	thyroglobulin	49,62	Sortilin	thyroglobulin	null	24826(Tax:10116)	Chemical	Gene	receptor|nsubj|START_ENTITY receptor|nmod|END_ENTITY	Sortilin is a putative postendocytic receptor of thyroglobulin .
26049551	0	Sotagliflozin	0,13	Insulin	71,78	Sotagliflozin	Insulin	null	3630	Chemical	Gene	START_ENTITY|nmod|Therapy Therapy|nmod|END_ENTITY	Sotagliflozin , a Dual SGLT1 and SGLT2 Inhibitor , as Adjunct Therapy to Insulin in Type 1 Diabetes .
2445004	0	Spantide	98,106	substance_P_receptor	65,85	Spantide	substance P receptor	MESH:C042867	21336(Tax:10090)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	Antinociceptive effects in mice after intrathecal injection of a substance_P_receptor antagonist , Spantide : lack of ` neurotoxic ' action .
25573805	0	Sparstolonin_B	22,36	TLR2	50,54	Sparstolonin B	TLR2	MESH:C561322	24088(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Protective effects of Sparstolonin_B , a selective TLR2 and TLR4 antagonist , on mouse endotoxin_shock .
25526088	0	Spermidine	0,10	EP300	65,70	Spermidine	EP300	MESH:D013095	2033	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|inhibiting inhibiting|dobj|END_ENTITY	Spermidine induces autophagy by inhibiting the acetyltransferase EP300 .
22925630	0	Spermidine	0,10	MMP-2	20,25	Spermidine	MMP-2	MESH:D013095	4313	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Spermidine inhibits MMP-2 via modulation of histone acetyltransferase and histone deacetylase in HDFs .
1872863	0	Spermidine	0,10	ornithine_decarboxylase	25,48	Spermidine	ornithine decarboxylase	MESH:D013095	4953	Chemical	Gene	START_ENTITY|dobj|regulation regulation|nmod|synthesis synthesis|amod|END_ENTITY	Spermidine regulation of ornithine_decarboxylase synthesis by a GC-rich sequence of the 5 ' - untranslated region .
3091594	0	Spermidine	0,10	ornithine_decarboxylase	55,78	Spermidine	ornithine decarboxylase	MESH:D013095	4953	Chemical	Gene	N1-acetyltransferase|amod|START_ENTITY has|nsubj|N1-acetyltransferase has|dobj|role role|nmod|END_ENTITY	Spermidine N1-acetyltransferase has a larger role than ornithine_decarboxylase in 1 alpha,25-dihydroxyvitamin _ D3-induced putrescine synthesis .
7583322	0	Spermine	0,8	CA1	53,56	Spermine	CA1	MESH:D013096	759	Chemical	Gene	increases|nsubj|START_ENTITY increases|nmod|END_ENTITY	Spermine increases paired-pulse facilitation in area CA1 of hippocampus in a calcium-dependent manner .
7439626	0	Spermine	0,8	CCl4	24,28	Spermine	CCl4	MESH:D013096	100008984(Tax:9986)	Chemical	Gene	stimulation|amod|START_ENTITY stimulation|nmod|END_ENTITY	Spermine stimulation of CCl4 depressed protein synthesis in rabbits .
15972654	0	Spermine	0,8	LFA-1	42,47	Spermine	LFA-1	MESH:D013096	3683	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Spermine , a natural polyamine , suppresses LFA-1 expression on human lymphocyte .
18693700	0	Spermine	0,8	alpha-synuclein	40,55	Spermine	alpha-synuclein	MESH:D013096	6622	Chemical	Gene	START_ENTITY|xcomp|binding binding|nmod|END_ENTITY	Spermine binding to Parkinson 's protein alpha-synuclein and its disease-related A30P and A53T mutants .
10371145	0	Spermine	0,8	caspase-3	36,45	Spermine	caspase-3	MESH:D013096	836	Chemical	Gene	triggers|nsubj|START_ENTITY triggers|dobj|activation activation|nmod|END_ENTITY	Spermine triggers the activation of caspase-3 in a cell-free model of apoptosis .
25692976	0	Spheroid	21,29	Huh7	14,18	Spheroid	Huh7	null	284424	Chemical	Gene	START_ENTITY|nsubj|Modulation Modulation|nmod|END_ENTITY	Modulation of Huh7 .5 Spheroid Formation and Functionality Using Modified PEG-Based Hydrogels of Different Stiffness .
8702592	0	Sphingomyelin	0,13	lecithin-cholesterol_acyltransferase	27,63	Sphingomyelin	lecithin-cholesterol acyltransferase	CHEBI:17636	3931	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|reaction reaction|amod|END_ENTITY	Sphingomyelin inhibits the lecithin-cholesterol_acyltransferase reaction with reconstituted high density lipoproteins by decreasing enzyme binding .
19524527	0	Sphingosine	0,11	SNARE	24,29	Sphingosine	SNARE	MESH:D013110	56494(Tax:10090)	Chemical	Gene	facilitates|amod|START_ENTITY END_ENTITY|nsubj|facilitates	Sphingosine facilitates SNARE complex assembly and activates synaptic vesicle exocytosis .
20558741	0	Sphingosine	0,11	acidic_leucine-rich_nuclear_phosphoprotein-32A	29,75	Sphingosine	acidic leucine-rich nuclear phosphoprotein-32A	MESH:D013110	8125	Chemical	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	Sphingosine interaction with acidic_leucine-rich_nuclear_phosphoprotein-32A -LRB- ANP32A -RRB- regulates PP2A activity and cyclooxygenase _ -LRB- COX -RRB- -2 expression in human endothelial cells .
7548113	0	Sphingosine	0,11	diacylglycerol_kinase	31,52	Sphingosine	diacylglycerol kinase	MESH:D013110	1607	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Sphingosine activates cellular diacylglycerol_kinase in intact Jurkat cells , a human T-cell line .
9706871	0	Sphingosine	0,11	interleukin-6	22,35	Sphingosine	interleukin-6	MESH:D013110	16193(Tax:10090)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|synthesis synthesis|amod|END_ENTITY	Sphingosine modulates interleukin-6 synthesis in osteoblasts .
7525558	0	Sphingosine	0,11	p125FAK	20,27	Sphingosine	p125FAK	MESH:D013110	14083(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|amod|END_ENTITY	Sphingosine induces p125FAK and paxillin tyrosine phosphorylation , actin stress fiber formation , and focal contact assembly in Swiss_3T3 cells .
9030540	0	Sphingosine	0,11	tumor_necrosis_factor-alpha	65,92	Sphingosine	tumor necrosis factor-alpha	MESH:D013110	7124	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|dobj|effects effects|nmod|END_ENTITY	Sphingosine mediates the immediate negative inotropic effects of tumor_necrosis_factor-alpha in the adult mammalian cardiac myocyte .
27079615	0	Sphingosine-1-Phosphate	47,70	DRA	39,42	Sphingosine-1-Phosphate	DRA	MESH:C060506	1811	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|appos|END_ENTITY	Transcriptional Modulation of SLC26A3 -LRB- DRA -RRB- by Sphingosine-1-Phosphate .
25748447	0	Sphingosine-1-Phosphate	0,23	MicroRNA-17	96,107	Sphingosine-1-Phosphate	MicroRNA-17	MESH:C060506	406952	Chemical	Gene	Induces|nsubj|START_ENTITY Induces|nmod|Pathway Pathway|compound|END_ENTITY	Sphingosine-1-Phosphate Induces the Migration of Thyroid Follicular_Carcinoma Cells through the MicroRNA-17 / PTK6/ERK1/2 Pathway .
26208383	0	Sphingosine-1-Phosphate	0,23	Platelet-Derived_Growth_Factor_Receptor-b	144,185	Sphingosine-1-Phosphate	Platelet-Derived Growth Factor Receptor-b	MESH:C060506	5159	Chemical	Gene	Induces|nsubj|START_ENTITY Induces|dep|END_ENTITY	Sphingosine-1-Phosphate Induces the Migration and Angiogenesis of Epcs Through the Akt Signaling Pathway via Sphingosine-1-Phosphate_Receptor_3 / Platelet-Derived_Growth_Factor_Receptor-b .
26824863	0	Sphingosine-1-Phosphate	0,23	S1P1	95,99	Sphingosine-1-Phosphate	S1P1	MESH:C060506	1901	Chemical	Gene	Induces|nsubj|START_ENTITY Induces|nmod|Activation Activation|compound|END_ENTITY	Sphingosine-1-Phosphate Induces Dose-Dependent Chemotaxis or Fugetaxis of T-ALL Blasts through S1P1 Activation .
27079615	0	Sphingosine-1-Phosphate	47,70	SLC26A3	30,37	Sphingosine-1-Phosphate	SLC26A3	MESH:C060506	1811	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|END_ENTITY	Transcriptional Modulation of SLC26A3 -LRB- DRA -RRB- by Sphingosine-1-Phosphate .
18654850	0	Sphingosine-1-phosphate	0,23	Akt	88,91	Sphingosine-1-phosphate	Akt	MESH:C060506	207	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|END_ENTITY	Sphingosine-1-phosphate protects intestinal epithelial cells from apoptosis through the Akt signaling pathway .
16508949	0	Sphingosine-1-phosphate	0,23	COX-2	32,37	Sphingosine-1-phosphate	COX-2	MESH:C060506	26198(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Sphingosine-1-phosphate induces COX-2 expression via PI3K/Akt and p42/p44 _ MAPK pathways in rat vascular smooth muscle cells .
26994820	0	Sphingosine-1-phosphate	0,23	COX-2	32,37	Sphingosine-1-phosphate	COX-2	MESH:C060506	5743	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Sphingosine-1-phosphate induces COX-2 expression and PGE2 production in human granulosa cells through a S1P1/3-mediated YAP signaling .
20936358	0	Sphingosine-1-phosphate	0,23	E-cadherin	78,88	Sphingosine-1-phosphate	E-cadherin	MESH:C060506	999	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Sphingosine-1-phosphate regulates the expression of adherens junction protein E-cadherin and enhances intestinal epithelial cell barrier function .
23377549	0	Sphingosine-1-phosphate	0,23	MMP-2	60,65	Sphingosine-1-phosphate	MMP-2	MESH:C060506	4313	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|pathway pathway|compound|END_ENTITY	Sphingosine-1-phosphate induces VEGF-C expression through a MMP-2 / FGF-1 / FGFR-1-dependent pathway in endothelial cells in vitro .
24990321	0	Sphingosine-1-phosphate	0,23	PAR-4	50,55	Sphingosine-1-phosphate	PAR-4	MESH:C060506	347745	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Sphingosine-1-phosphate induces thrombin receptor PAR-4 expression to enhance cell migration and COX-2 formation in human monocytes .
19374869	0	Sphingosine-1-phosphate	0,23	RGS2	34,38	Sphingosine-1-phosphate	RGS2	MESH:C060506	5997	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Sphingosine-1-phosphate regulates RGS2 and RGS16 mRNA expression in vascular smooth muscle cells .
20382120	0	Sphingosine-1-phosphate	0,23	VEGF	50,54	Sphingosine-1-phosphate	VEGF	MESH:C060506	7422	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Sphingosine-1-phosphate induces human endothelial VEGF and MMP-2 production via transcription factor ZNF580 : novel insights into angiogenesis .
23377549	0	Sphingosine-1-phosphate	0,23	VEGF-C	32,38	Sphingosine-1-phosphate	VEGF-C	MESH:C060506	7424	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Sphingosine-1-phosphate induces VEGF-C expression through a MMP-2 / FGF-1 / FGFR-1-dependent pathway in endothelial cells in vitro .
24035571	0	Sphingosine-1-phosphate	0,23	connective_tissue_growth_factor	35,66	Sphingosine-1-phosphate	connective tissue growth factor	MESH:C060506	1490	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Sphingosine-1-phosphate stimulated connective_tissue_growth_factor expression in human buccal fibroblasts : Inhibition by epigallocatechin-3-gallate .
18191017	0	Sphingosine-1-phosphate	0,23	liver_receptor_homologue-1	56,82	Sphingosine-1-phosphate	liver receptor homologue-1	MESH:C060506	2494	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Sphingosine-1-phosphate regulates the expression of the liver_receptor_homologue-1 .
15743789	0	Sphingosine-1-phosphate	0,23	nuclear_factor_kappaB	33,54	Sphingosine-1-phosphate	nuclear factor kappaB	MESH:C060506	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	Sphingosine-1-phosphate inhibits nuclear_factor_kappaB activation and germ cell apoptosis in the human testis independently of its receptors .
18164686	0	Sphingosine-1-phosphate	0,23	p130Cas	97,104	Sphingosine-1-phosphate	p130Cas	MESH:C060506	9564	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Sphingosine-1-phosphate induces the association of membrane-type_1_matrix_metalloproteinase with p130Cas in endothelial cells .
22298596	0	Sphingosine-1-phosphate	0,23	sphingosine_kinase_1	36,56	Sphingosine-1-phosphate	sphingosine kinase 1	MESH:C060506	8877	Chemical	Gene	START_ENTITY|acl|produced produced|nmod|END_ENTITY	Sphingosine-1-phosphate produced by sphingosine_kinase_1 promotes breast_cancer progression by stimulating angiogenesis and lymphangiogenesis .
24285115	0	Sphingosine-1-phosphate	0,23	syndecan-1	70,80	Sphingosine-1-phosphate	syndecan-1	MESH:C060506	25216(Tax:10116)	Chemical	Gene	protects|nsubj|START_ENTITY protects|advcl|inhibiting inhibiting|dobj|END_ENTITY	Sphingosine-1-phosphate protects endothelial glycocalyx by inhibiting syndecan-1 shedding .
24990321	0	Sphingosine-1-phosphate	0,23	thrombin	32,40	Sphingosine-1-phosphate	thrombin	MESH:C060506	2147	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Sphingosine-1-phosphate induces thrombin receptor PAR-4 expression to enhance cell migration and COX-2 formation in human monocytes .
22898216	0	Sphingosine-1-phosphate	0,23	vascular_endothelial_growth_factor	48,82	Sphingosine-1-phosphate	vascular endothelial growth factor	MESH:C060506	7422	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Sphingosine-1-phosphate modulates expression of vascular_endothelial_growth_factor in human articular chondrocytes : a possible new role in arthritis .
11278592	0	Sphingosine_1-phosphate	0,23	Akt	34,37	Sphingosine 1-phosphate	Akt	MESH:C060506	207	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Sphingosine_1-phosphate activates Akt , nitric_oxide production , and chemotaxis through a Gi protein/phosphoinositide 3-kinase pathway in endothelial cells .
24064301	0	Sphingosine_1-phosphate	0,23	COX-2	38,43	Sphingosine 1-phosphate	COX-2	MESH:C060506	26198(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Sphingosine_1-phosphate -LRB- S1P -RRB- induces COX-2 expression and PGE2 formation via S1P_receptor_2 in renal_mesangial_cells .
12875654	0	Sphingosine_1-phosphate	0,23	Cdc42	74,79	Sphingosine 1-phosphate	Cdc42	MESH:C060506	998	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|activation activation|nmod|END_ENTITY	Sphingosine_1-phosphate promotes cell migration through the activation of Cdc42 in Edg-6 / S1P4-expressing cells .
9195921	0	Sphingosine_1-phosphate	0,23	Crk	63,66	Sphingosine 1-phosphate	Crk	MESH:C060506	1398	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Sphingosine_1-phosphate stimulates tyrosine phosphorylation of Crk .
26518876	0	Sphingosine_1-phosphate	57,80	Cyclooxygenase-2	21,37	Sphingosine 1-phosphate	Cyclooxygenase-2	MESH:C060506	5743	Chemical	Gene	Receptor|compound|START_ENTITY Expression|nmod|Receptor Expression|compound|END_ENTITY	Taurocholate Induces Cyclooxygenase-2 Expression via the Sphingosine_1-phosphate Receptor 2 in a Human_Cholangiocarcinoma Cell Line .
20656374	0	Sphingosine_1-phosphate	0,23	E-selectin	52,62	Sphingosine 1-phosphate	E-selectin	MESH:C060506	6401	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Sphingosine_1-phosphate -LRB- S1P -RRB- induces expression of E-selectin and adhesion of monocytes via intracellular signalling pathways in vascular endothelial cells .
15556605	0	Sphingosine_1-phosphate	0,23	EGFR	90,94	Sphingosine 1-phosphate	EGFR	MESH:C060506	1956	Chemical	Gene	transactivates|amod|START_ENTITY transactivates|appos|END_ENTITY	Sphingosine_1-phosphate transactivates c-Met as well as epidermal_growth_factor_receptor -LRB- EGFR -RRB- in human gastric_cancer cells .
17902169	0	Sphingosine_1-phosphate	0,23	EGFR	32,36	Sphingosine 1-phosphate	EGFR	MESH:C060506	24329(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Sphingosine_1-phosphate induces EGFR expression via Akt/NF-kappaB and ERK/AP -1 pathways in rat vascular smooth muscle cells .
9480864	0	Sphingosine_1-phosphate	0,23	Edg-1	74,79	Sphingosine 1-phosphate	Edg-1	MESH:C060506	1901	Chemical	Gene	START_ENTITY|acl|signalling signalling|nmod|END_ENTITY	Sphingosine_1-phosphate signalling through the G-protein-coupled receptor Edg-1 .
25035231	0	Sphingosine_1-phosphate	0,23	IL-4	105,109	Sphingosine 1-phosphate	IL-4	MESH:C060506	3565	Chemical	Gene	induced|nsubj|START_ENTITY induced|nmod|END_ENTITY	Sphingosine_1-phosphate induced anti-atherogenic and atheroprotective M2 macrophage polarization through IL-4 .
26321412	0	Sphingosine_1-phosphate	0,23	IL-8	34,38	Sphingosine 1-phosphate	IL-8	MESH:C060506	3576	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Sphingosine_1-phosphate regulates IL-8 expression and secretion via S1PR1 and S1PR2 receptors-mediated signaling in extravillous trophoblast derived HTR-8 / SVneo cells .
22743041	0	Sphingosine_1-phosphate	0,23	MKP-1	32,37	Sphingosine 1-phosphate	MKP-1	MESH:C060506	1843	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Sphingosine_1-phosphate induces MKP-1 expression via p38 MAPK - and CREB-mediated pathways in airway smooth muscle cells .
15371328	0	Sphingosine_1-phosphate	0,23	N-cadherin	47,57	Sphingosine 1-phosphate	N-cadherin	MESH:C060506	1000	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Sphingosine_1-phosphate receptor regulation of N-cadherin mediates vascular stabilization .
24293320	0	Sphingosine_1-phosphate	0,23	Peroxisome_proliferator-activated_receptor_y_coactivator_1a	94,153	Sphingosine 1-phosphate	Peroxisome proliferator-activated receptor y coactivator 1a	MESH:C060506	10891	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Sphingosine_1-phosphate -LRB- S1P -RRB- promotes mitochondrial biogenesis in Hep G2 cells by activating Peroxisome_proliferator-activated_receptor_y_coactivator_1a -LRB- PGC-1a -RRB- .
14732717	0	Sphingosine_1-phosphate	0,23	S1P	25,28	Sphingosine 1-phosphate	S1P	MESH:C060506	13609(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Sphingosine_1-phosphate -LRB- S1P -RRB- receptor subtypes S1P1 and S1P3 , respectively , regulate lymphocyte recirculation and heart rate .
22178384	0	Sphingosine_1-phosphate	0,23	S1P	91,94	Sphingosine 1-phosphate	S1P	MESH:C060506	13609(Tax:10090)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|proliferation proliferation|dep|role role|nmod|receptors receptors|nummod|END_ENTITY	Sphingosine_1-phosphate stimulates proliferation and migration of satellite cells : role of S1P receptors .
17331465	0	Sphingosine_1-phosphate	0,23	S1P1_and_S1P3	96,109	Sphingosine 1-phosphate	S1P1 and S1P3	MESH:C060506	1901;1903	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Sphingosine_1-phosphate regulates inflammation-related genes in human endothelial cells through S1P1_and_S1P3 .
12667959	0	Sphingosine_1-phosphate	0,23	S1P2	87,91	Sphingosine 1-phosphate	S1P2	MESH:C060506	9294	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|contraction contraction|nmod|END_ENTITY	Sphingosine_1-phosphate induces contraction of coronary artery smooth muscle cells via S1P2 .
15213242	0	Sphingosine_1-phosphate	0,23	S1P2	64,68	Sphingosine 1-phosphate	S1P2	MESH:C060506	29415(Tax:10116)	Chemical	Gene	migration|amod|START_ENTITY migration|nmod|cells cells|nmod|END_ENTITY	Sphingosine_1-phosphate inhibits migration of RBL-2H3 cells via S1P2 : cross-talk between platelets and mast cells .
15240112	0	Sphingosine_1-phosphate	0,23	S1P2	80,84	Sphingosine 1-phosphate	S1P2	MESH:C060506	29415(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|liver liver|nmod|END_ENTITY	Sphingosine_1-phosphate enhances portal pressure in isolated perfused liver via S1P2 with Rho activation .
17287522	0	Sphingosine_1-phosphate	0,23	S1P2	107,111	Sphingosine 1-phosphate	S1P2	MESH:C060506	9294	Chemical	Gene	signaling|amod|START_ENTITY required|nsubjpass|signaling required|nmod|activation activation|nmod|END_ENTITY	Sphingosine_1-phosphate -LRB- S1P -RRB- signaling is required for maintenance of hair cells mainly via activation of S1P2 .
17637200	0	Sphingosine_1-phosphate	0,23	S1P2	86,90	Sphingosine 1-phosphate	S1P2	MESH:C060506	29415(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|receptor receptor|compound|END_ENTITY	Sphingosine_1-phosphate -LRB- S1P -RRB- induces shape change in rat C6 glioma cells through the S1P2 receptor : development of an agonist for S1P receptors .
22913344	0	Sphingosine_1-phosphate	0,23	S1P2	38,42	Sphingosine 1-phosphate	S1P2	MESH:C060506	14739(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|contraction contraction|nummod|END_ENTITY	Sphingosine_1-phosphate -LRB- S1P -RRB- induces S1P2 receptor-dependent tonic contraction in murine iliac lymph vessels .
23589284	0	Sphingosine_1-phosphate	0,23	S1P2	116,120	Sphingosine 1-phosphate	S1P2	MESH:C060506	9294	Chemical	Gene	agonists|amod|START_ENTITY mediate|nsubj|agonists mediate|nmod|fibroblasts fibroblasts|nmod|receptors receptors|compound|END_ENTITY	Sphingosine_1-phosphate -LRB- S1P -RRB- receptor agonists mediate pro-fibrotic responses in normal human lung fibroblasts via S1P2 and S1P3 receptors and Smad-independent signaling .
27080739	0	Sphingosine_1-phosphate	0,23	S1P2	36,40	Sphingosine 1-phosphate	S1P2	MESH:C060506	14739(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Sphingosine_1-phosphate receptor 2 -LRB- S1P2 -RRB- attenuates reactive_oxygen_species formation and inhibits cell death : implications for otoprotective therapy .
23658964	0	Sphingosine_1-phosphate	59,82	S1P3	95,99	Sphingosine 1-phosphate	S1P3	MESH:C060506	1903	Chemical	Gene	Sphingosine_1-phosphate|amod|START_ENTITY Sphingosine_1-phosphate|appos|END_ENTITY	Probe Development Efforts for an Allosteric Agonist of the Sphingosine_1-phosphate Receptor 3 -LRB- S1P3 -RRB- Sphingosine_1-phosphate -LRB- S1P -RRB- is a bioactive phospholipid released by activated blood platelets that serves to influence heart rate , coronary artery caliber , endothelial integrity , lung epithelial integrity and lymphocyte recirculation through five related high affinity G-protein coupled receptors .
21433398	0	Sphingosine_1-phosphate	63,86	S1P4	99,103	Sphingosine 1-phosphate	S1P4	MESH:C060506	8698	Chemical	Gene	Antagonists|nmod|START_ENTITY Efforts|nmod|Antagonists Efforts|dobj|Receptor Receptor|appos|END_ENTITY	Probe Development Efforts to Identify Novel Antagonists of the Sphingosine_1-phosphate Receptor 4 -LRB- S1P4 -RRB- Pandemic influenza represents a significant public health threat , due in part to immune cell-mediated lung tissue damage induced during viral_infection .
22834032	0	Sphingosine_1-phosphate	60,83	S1P4	96,100	Sphingosine 1-phosphate	S1P4	MESH:C060506	8698	Chemical	Gene	Sphingosine_1-phosphate|amod|START_ENTITY Sphingosine_1-phosphate|appos|END_ENTITY	Probe Development Efforts to Identify Novel Agonists of the Sphingosine_1-phosphate Receptor 4 -LRB- S1P4 -RRB- Sphingosine_1-phosphate -LRB- S1P -RRB- is a bioactive phospholipid released by activated blood platelets that serves to influence heart rate , coronary artery caliber , endothelial integrity , lung epithelial integrity and lymphocyte recirculation through five related high affinity G-protein coupled receptors .
23762926	0	Sphingosine_1-phosphate	41,64	S1P4	77,81	Sphingosine 1-phosphate	S1P4	MESH:C060506	8698	Chemical	Gene	Sphingosine_1-phosphate|amod|START_ENTITY Sphingosine_1-phosphate|appos|END_ENTITY	Identification of a Novel Agonist of the Sphingosine_1-phosphate Receptor 4 -LRB- S1P4 -RRB- Sphingosine_1-phosphate -LRB- S1P -RRB- is a bioactive phospholipid released by activated blood platelets that serves to influence heart rate , coronary artery caliber , endothelial integrity , lung epithelial integrity , and lymphocyte recirculation through five related high affinity G-protein coupled receptors .
26321412	0	Sphingosine_1-phosphate	0,23	S1PR1	68,73	Sphingosine 1-phosphate	S1PR1	MESH:C060506	1901	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Sphingosine_1-phosphate regulates IL-8 expression and secretion via S1PR1 and S1PR2 receptors-mediated signaling in extravillous trophoblast derived HTR-8 / SVneo cells .
24064301	0	Sphingosine_1-phosphate	0,23	S1P_receptor_2	78,92	Sphingosine 1-phosphate	S1P receptor 2	MESH:C060506	29415(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Sphingosine_1-phosphate -LRB- S1P -RRB- induces COX-2 expression and PGE2 formation via S1P_receptor_2 in renal_mesangial_cells .
24743449	0	Sphingosine_1-phosphate	0,23	S1P_receptor_2	82,96	Sphingosine 1-phosphate	S1P receptor 2	MESH:C060506	9294	Chemical	Gene	induced|nsubj|START_ENTITY induced|dobj|release release|acl:relcl|mediated mediated|nmod|END_ENTITY	Sphingosine_1-phosphate -LRB- S1P -RRB- induced interleukin-8 -LRB- IL-8 -RRB- release is mediated by S1P_receptor_2 and nuclear factor kB in BEAS-2B cells .
17670896	0	Sphingosine_1-phosphate	0,23	VE-cadherin	88,99	Sphingosine 1-phosphate	VE-cadherin	MESH:C060506	1003	Chemical	Gene	increases|nsubj|START_ENTITY increases|nmod|END_ENTITY	Sphingosine_1-phosphate rapidly increases endothelial barrier function independently of VE-cadherin but requires cell spreading and Rho kinase .
18502612	0	Sphingosine_1-phosphate	0,23	cSrc	129,133	Sphingosine 1-phosphate	cSrc	MESH:C060506	6714	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Sphingosine_1-phosphate induces platelet/endothelial _ cell_adhesion_molecule-1 phosphorylation in human endothelial cells through cSrc and Fyn .
12796504	0	Sphingosine_1-phosphate	0,23	cyclooxygenase-2	52,68	Sphingosine 1-phosphate	cyclooxygenase-2	MESH:C060506	5743	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	Sphingosine_1-phosphate in amniotic fluid modulates cyclooxygenase-2 expression in human amnion-derived WISH cells .
15625281	0	Sphingosine_1-phosphate	0,23	cyclooxygenase-2	86,102	Sphingosine 1-phosphate	cyclooxygenase-2	MESH:C060506	5743	Chemical	Gene	receptors|amod|START_ENTITY mediate|nsubj|receptors mediate|nmod|pathway pathway|amod|END_ENTITY	Sphingosine_1-phosphate receptors mediate the lipid-induced cAMP accumulation through cyclooxygenase-2 / prostaglandin I2 pathway in human coronary artery smooth muscle cells .
17382352	0	Sphingosine_1-phosphate	0,23	cyclooxygenase-2	32,48	Sphingosine 1-phosphate	cyclooxygenase-2	MESH:C060506	29527(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Sphingosine_1-phosphate induces cyclooxygenase-2 via Ca2 + - dependent , but MAPK-independent mechanism in rat vascular smooth muscle cells .
21652634	0	Sphingosine_1-phosphate	0,23	matrix_metalloproteinase-9	34,60	Sphingosine 1-phosphate	matrix metalloproteinase-9	MESH:C060506	4318	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Sphingosine_1-phosphate regulates matrix_metalloproteinase-9 expression and breast cell invasion through S1P3-Gaq coupling .
21368227	0	Sphingosylphosphorylcholine	0,27	CCL2	39,43	Sphingosylphosphorylcholine	CCL2	MESH:C005356	6347	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|compound|END_ENTITY	Sphingosylphosphorylcholine stimulates CCL2 production from human umbilical vein endothelial cells .
17131361	0	Sphingosylphosphorylcholine	0,27	ERK	122,125	Sphingosylphosphorylcholine	ERK	MESH:C005356	5594	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Sphingosylphosphorylcholine induces apoptosis of endothelial cells through reactive_oxygen_species-mediated activation of ERK .
20230798	0	Sphingosylphosphorylcholine	0,27	filaggrin	43,52	Sphingosylphosphorylcholine	filaggrin	MESH:C005356	2312	Chemical	Gene	down-regulates|amod|START_ENTITY END_ENTITY|nsubj|down-regulates	Sphingosylphosphorylcholine down-regulates filaggrin gene transcription through NOX5-based NADPH oxidase and cyclooxygenase-2 in human keratinocytes .
9886270	0	Sphingosylphosphorylcholine	0,27	intercellular_adhesion_molecule-1	51,84	Sphingosylphosphorylcholine	intercellular adhesion molecule-1	MESH:C005356	3383	Chemical	Gene	inducer|nsubj|START_ENTITY inducer|nmod|expression expression|amod|END_ENTITY	Sphingosylphosphorylcholine is a potent inducer of intercellular_adhesion_molecule-1 expression in human keratinocytes .
7592646	0	Sphingosylphosphorylcholine	0,27	p125FAK	72,79	Sphingosylphosphorylcholine	p125FAK	MESH:C005356	14083(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Sphingosylphosphorylcholine rapidly induces tyrosine phosphorylation of p125FAK and paxillin , rearrangement of the actin cytoskeleton and focal contact assembly .
24792393	0	Spicatoside_A	0,13	brain-derived_neurotrophic_factor	56,89	Spicatoside A	brain-derived neurotrophic factor	MESH:C546003	12064(Tax:10090)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Spicatoside_A enhances memory consolidation through the brain-derived_neurotrophic_factor in mice .
26319558	0	Spine	28,33	miR-132	0,7	Spine	miR-132	null	387150(Tax:10090)	Chemical	Gene	Structure|compound|START_ENTITY Structure|amod|END_ENTITY	miR-132 Regulates Dendritic Spine Structure by Direct Targeting of Matrix_Metalloproteinase_9 mRNA .
24582422	0	Spinosad	0,8	P-glycoprotein	41,55	Spinosad	P-glycoprotein	MESH:C415329	610926(Tax:9615)	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Spinosad is a potent inhibitor of canine P-glycoprotein .
11220887	0	Spirapril	1,10	ACE	31,34	Spirapril	ACE	MESH:C052555	1636	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	-LSB- Spirapril - a new long-acting ACE inhibitor : efficacy and safety in patients with arterial_hypertension in combination with diabetes_mellitus and impaired_kidney_function -RSB- .
11835060	0	Spirapril	44,53	Ace	63,66	Spirapril	Ace	MESH:C052555	1636	Chemical	Gene	Hydrochlorothiazide|nmod|START_ENTITY Interaction|nmod|Hydrochlorothiazide Interaction|dep|Inhibitor Inhibitor|compound|END_ENTITY	The Interaction of Hydrochlorothiazide with Spirapril : A Novel Ace Inhibitor .
23659282	0	Spirohexenolide_A	0,17	macrophage_migration_inhibitory_factor	32,70	Spirohexenolide A	macrophage migration inhibitory factor	MESH:C547347	4282	Chemical	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Spirohexenolide_A targets human macrophage_migration_inhibitory_factor -LRB- hMIF -RRB- .
16882069	0	Spironolactone	0,14	ACE	20,23	Spironolactone	ACE	MESH:D013148	1636	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|compound|END_ENTITY	Spironolactone with ACE inhibitor is effective in gross hematuria caused by nephroptosis .
26065643	0	Spironolactone	0,14	HCN	25,28	Spironolactone	HCN	MESH:D013148	85259(Tax:10116)	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Spironolactone Regulates HCN Protein Expression Through Micro-RNA-1 in Rats With Myocardial_Infarction .
25626766	0	Spironolactone	13,27	Matrix_Metalloproteinase-2	31,57	Spironolactone	Matrix Metalloproteinase-2	MESH:D013148	4313	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of Spironolactone on Matrix_Metalloproteinase-2 in Acute Decompensated_Heart_Failure .
25626766	0	Spironolactone	13,27	Matrix_Metalloproteinase-2	31,57	Spironolactone	Matrix Metalloproteinase-2	MESH:D013148	4313	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of Spironolactone on Matrix_Metalloproteinase-2 in Acute Decompensated_Heart_Failure .
25993594	0	Spironolactone	13,27	Matrix_Metalloproteinase-2	31,57	Spironolactone	Matrix Metalloproteinase-2	MESH:D013148	4313	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of Spironolactone on Matrix_Metalloproteinase-2 in Acute Decompensated_Heart_Failure .
20228418	0	Spironolactone	0,14	hypoxia-inducible_factor-1_alpha	47,79	Spironolactone	hypoxia-inducible factor-1 alpha	MESH:D013148	29560(Tax:10116)	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|expression expression|amod|END_ENTITY	Spironolactone , but not enalapril , potentiates hypoxia-inducible_factor-1_alpha and Ets-1 expression in newborn rat kidney .
12242040	0	Spironolactone	0,14	integrin_beta3	25,39	Spironolactone	integrin beta3	MESH:D013148	29302(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Spironolactone increases integrin_beta3 gene expression in kidney and heart muscle cells .
19674898	0	Spiropiperidine	0,15	CCR5	16,20	Spiropiperidine	CCR5	null	1234	Chemical	Gene	START_ENTITY|dobj|antagonists antagonists|nummod|END_ENTITY	Spiropiperidine CCR5 antagonists .
7517439	0	Spiroquinazoline	0,16	substance_P	26,37	Spiroquinazoline	substance P	MESH:C088106	6863	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Spiroquinazoline , a novel substance_P inhibitor with a new carbon skeleton , isolated from Aspergillus_flavipes .
18343365	0	Spisulosine	0,11	PC-3	44,48	Spisulosine	PC-3	MESH:C408363	5122	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Spisulosine -LRB- ES-285 -RRB- induces prostate_tumor PC-3 and LNCaP cell death by de novo synthesis of ceramide and PKCzeta activation .
9886929	0	Squalamine	0,10	NHE3	102,106	Squalamine	NHE3	MESH:C079655	100009430(Tax:9986)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Squalamine , a novel cationic steroid , specifically inhibits the brush-border Na + / H + exchanger isoform NHE3 .
26956235	0	Squalene	0,8	peroxisome_proliferator-activated_receptor-a	53,97	Squalene	peroxisome proliferator-activated receptor-a	MESH:D013185	5465	Chemical	Gene	agonist|nsubj|START_ENTITY agonist|amod|END_ENTITY	Squalene isolated from Schizochytrium mangrovei is a peroxisome_proliferator-activated_receptor-a agonist that regulates lipid metabolism in HepG2 cells .
23755593	0	Sr2SiO4	66,73	BaF2	10,14	Sr2SiO4	BaF2	null	140836	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of BaF2 on crystal structure and luminescent properties of Sr2SiO4 : Eu2 + for light emitting diode lighting .
23610071	0	Stathmin	0,8	p53	26,29	Stathmin	p53	null	7157	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|stability stability|compound|END_ENTITY	Stathmin regulates mutant p53 stability and transcriptional activity in ovarian_cancer .
11927515	0	Statin	0,6	C-reactive_protein	30,48	Statin	C-reactive protein	CHEBI:35664	1401	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|increase increase|nmod|END_ENTITY	Statin attenuates increase in C-reactive_protein during estrogen replacement therapy in postmenopausal women .
23369699	0	Statin	25,31	CXCL12	55,61	Statin	CXCL12	CHEBI:35664	6387	Chemical	Gene	Therapy|compound|START_ENTITY Therapy|nmod|Levels Levels|compound|END_ENTITY	Dose-dependent Effect of Statin Therapy on Circulating CXCL12 Levels in Patients with Hyperlipidemia .
26510755	0	Statin	10,16	Familial_Hypercholesterolemia	73,102	Statin	Familial Hypercholesterolemia	D019821	3949	Chemical	Gene	Therapy|compound|START_ENTITY Effect|nmod|Therapy Effect|nmod|Multiple_Xanthomas Multiple_Xanthomas|compound|END_ENTITY	Effect of Statin Therapy in 4-Year-Old Dichorionic Diamniotic Twins with Familial_Hypercholesterolemia Showing Multiple_Xanthomas .
12526087	0	Statin	0,6	ICAM-1	90,96	Statin	ICAM-1	CHEBI:35664	3383	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Statin inhibits interferon-gamma-induced expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- in vascular endothelial and smooth muscle cells .
15744552	0	Statin	0,6	P-selectin	28,38	Statin	P-selectin	CHEBI:35664	6403	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|amod|END_ENTITY	Statin reduces the platelet P-selectin expression in atherosclerotic_ischemic stroke .
19812448	0	Statin	0,6	hip	30,33	Statin	hip	D019821	6159	Chemical	Gene	therapy|compound|START_ENTITY therapy|nmod|END_ENTITY	Statin therapy and changes in hip circumference among HIV-infected participants in the ALLRT Cohort .
25490414	0	Statin	0,6	phospholipase_A2	44,60	Statin	phospholipase A2	CHEBI:35664	151056	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Statin inhibits the expression of secretory phospholipase_A2 and subsequent monocyte_chemoattractant_protein-1 in human endothelial cells .
20605197	0	Statins	10,17	Prostate-specific_Antigen	27,52	Statins	Prostate-specific Antigen	null	354	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|Levels Levels|compound|END_ENTITY	Effect of Statins on Serum Prostate-specific_Antigen Levels .
21463327	0	Statins	0,7	RANKL	40,45	Statins	RANKL	null	8600	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	Statins regulate interleukin-1b-induced RANKL and osteoprotegerin production by human gingival fibroblasts .
17184493	0	Statins	0,7	macrophage_inflammatory_protein-1alpha	15,53	Statins	macrophage inflammatory protein-1alpha	null	6348	Chemical	Gene	reduce|nsubj|START_ENTITY reduce|dobj|expression expression|amod|END_ENTITY	Statins reduce macrophage_inflammatory_protein-1alpha expression in human activated monocytes .
12960612	0	Statins	0,7	thrombomodulin	17,31	Statins	thrombomodulin	null	7056	Chemical	Gene	increase|nsubj|START_ENTITY increase|dobj|expression expression|amod|END_ENTITY	Statins increase thrombomodulin expression and function in human endothelial cells by a nitric_oxide-dependent mechanism and counteract tumor necrosis factor alpha-induced thrombomodulin downregulation .
8093679	0	Staurosporine	0,13	P-glycoprotein	22,36	Staurosporine	P-glycoprotein	MESH:D019311	5243	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|amod|END_ENTITY	Staurosporine reduces P-glycoprotein expression and modulates multidrug resistance .
7513708	0	Staurosporine	0,13	acetylcholine_receptor	37,59	Staurosporine	acetylcholine receptor	MESH:D019311	424940(Tax:9031)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Staurosporine inhibits agrin-induced acetylcholine_receptor phosphorylation and aggregation .
10789557	0	Staurosporine	0,13	carcinoembryonic_antigen	24,48	Staurosporine	carcinoembryonic antigen	MESH:D019311	1084	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Staurosporine increases carcinoembryonic_antigen expression in a human colon_cancer cell line .
9224627	0	Staurosporine	0,13	interleukin_1alpha	88,106	Staurosporine	interleukin 1alpha	MESH:D019311	16175(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Staurosporine , but not Ro_31-8220 , induces interleukin_2 production and synergizes with interleukin_1alpha in EL4 thymoma cells .
7735968	0	Staurosporine	0,13	tnf	63,66	Staurosporine	tnf	MESH:D019311	24835(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|production production|compound|END_ENTITY	Staurosporine encapsulated into pH-sensitive liposomes reduces tnf production and increases survival in rat endotoxin shock .
20109524	0	Stearoyl-CoA	77,89	SCD1	102,106	Stearoyl-CoA	SCD1	MESH:C017725	6319	Chemical	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Key role of the ERK1/2 MAPK pathway in the transcriptional regulation of the Stearoyl-CoA Desaturase -LRB- SCD1 -RRB- gene expression in response to leptin .
18254828	0	Stearoyl_CoA	0,12	SCD	25,28	Stearoyl CoA	SCD	MESH:C017725	280924(Tax:9913)	Chemical	Gene	polymorphisms|amod|START_ENTITY polymorphisms|appos|END_ENTITY	Stearoyl_CoA desaturase -LRB- SCD -RRB- gene polymorphisms in Italian cattle breeds .
15871910	0	Stepholidine	0,12	Akt	90,93	Stepholidine	Akt	MESH:C010513	24185(Tax:10116)	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|activation activation|nmod|END_ENTITY	Stepholidine protects against H2O2 neurotoxicity in rat cortical neurons by activation of Akt .
23209931	0	Sterculic_Oil	0,13	SCD1	25,29	Sterculic Oil	SCD1	null	20249(Tax:10090)	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|compound|END_ENTITY	Sterculic_Oil , a Natural SCD1 Inhibitor , Improves Glucose Tolerance in Obese_ob / ob_Mice .
18503190	0	Sterenin_A	0,10	11beta-hydroxysteroid_dehydrogenase_type_1	30,72	Sterenin A	11beta-hydroxysteroid dehydrogenase type 1	MESH:C532322	3290	Chemical	Gene	START_ENTITY|appos|inhibitors inhibitors|amod|END_ENTITY	Sterenin_A , B , C and D , novel 11beta-hydroxysteroid_dehydrogenase_type_1 inhibitors from Stereum sp .
3586673	0	Steroid	0,7	5_alpha-reductase	8,25	Steroid	5 alpha-reductase	CHEBI:35341	6715	Chemical	Gene	START_ENTITY|dobj|activity activity|amod|END_ENTITY	Steroid 5_alpha-reductase activity in endothelial cells from human umbilical cord vessels .
12570838	0	Steroid	0,7	5alpha-reductase	8,24	Steroid	5alpha-reductase	CHEBI:35341	6715	Chemical	Gene	START_ENTITY|dobj|inhibitors inhibitors|amod|END_ENTITY	Steroid 5alpha-reductase inhibitors .
2844095	0	Steroid	0,7	ACTH	29,33	Steroid	ACTH	CHEBI:35341	403659(Tax:9615)	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Steroid inhibition of canine ACTH : in vivo evidence for feedback at the corticotrope .
11142420	0	Steroid	0,7	CYP17	24,29	Steroid	CYP17	CHEBI:35341	1586	Chemical	Gene	gene|amod|START_ENTITY gene|dep|polymorphism polymorphism|compound|END_ENTITY	Steroid metabolism gene CYP17 polymorphism and the development of breast_cancer .
16731779	0	Steroid	0,7	Clca3	30,35	Steroid	Clca3	CHEBI:35341	23844(Tax:10090)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Steroid hormone regulation of Clca3 expression in the murine uterus .
12145347	0	Steroid	0,7	Cyp11a1	65,72	Steroid	Cyp11a1	CHEBI:35341	13070(Tax:10090)	Chemical	Gene	deficiency|amod|START_ENTITY syndromes|nsubj|deficiency syndromes|nmod|mice mice|nmod|disruption disruption|nmod|END_ENTITY	Steroid deficiency syndromes in mice with targeted disruption of Cyp11a1 .
18400107	0	Steroid	0,7	EMP2	30,34	Steroid	EMP2	CHEBI:35341	2013	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Steroid hormone regulation of EMP2 expression and localization in the endometrium .
17149689	0	Steroid	0,7	ERalpha	18,25	Steroid	ERalpha	CHEBI:35341	2099	Chemical	Gene	receptors|amod|START_ENTITY receptors|dep|END_ENTITY	Steroid receptors ERalpha , ERbeta , PR-A and PR-B are differentially expressed in normal and atrophic human endometrium .
26207344	0	Steroid	8,15	Glucocorticoid_Receptor	106,129	Steroid	Glucocorticoid Receptor	D013256	2908	Chemical	Gene	Accumulating|compound|START_ENTITY Lead|nsubj|Accumulating Lead|nmod|Transactivation Transactivation|nmod|END_ENTITY	Adrenal Steroid Metabolites Accumulating in Congenital_Adrenal_Hyperplasia Lead to Transactivation of the Glucocorticoid_Receptor .
27027943	0	Steroid	112,119	Glucocorticoid_Receptor	21,44	Steroid	Glucocorticoid Receptor	D013256	2908	Chemical	Gene	Efficacy|compound|START_ENTITY Mechanisms|nmod|Efficacy Analysis|nmod|Mechanisms Analysis|nmod|Activity Activity|compound|END_ENTITY	Cistrome Analysis of Glucocorticoid_Receptor Activity in Bronchial Epithelial Cells Defines Novel Mechanisms of Steroid Efficacy .
19446313	0	Steroid	0,7	HER2/neu	19,27	Steroid	HER2/neu	CHEBI:35341	2064	Chemical	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Steroid receptors , HER2/neu and Ki-67 , in endometrioid type of endometrial_carcinoma : Correlation with conventional histomorphological features of prognosis .
18212051	0	Steroid	0,7	IGF-I	83,88	Steroid	IGF-I	CHEBI:35341	16000(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY maintains|nsubj|receptor maintains|xcomp|circulating circulating|dobj|insulin-like_growth_factor_I insulin-like_growth_factor_I|appos|END_ENTITY	Steroid receptor coactivator 3 maintains circulating insulin-like_growth_factor_I -LRB- IGF-I -RRB- by controlling IGF-binding_protein_3 expression .
24009850	0	Steroid	37,44	IL-6	93,97	Steroid	IL-6	CHEBI:35341	3569	Chemical	Gene	START_ENTITY|nmod|Pathway Pathway|compound|END_ENTITY	Bacterial Lipopolysaccharides Induce Steroid Sulfatase Expression and Cell Migration through IL-6 Pathway in Human Prostate_Cancer Cells .
25948353	0	Steroid	59,66	IgA_Nephropathy	0,15	Steroid	IgA Nephropathy	D013256	60498	Chemical	Gene	Therapy|compound|START_ENTITY Improved|nmod|Therapy Improved|nsubj|END_ENTITY	IgA_Nephropathy and Psoriatic_Arthritis that Improved with Steroid Pulse Therapy and Mizoribine in Combination with Treatment for Chronic_Tonsillitis and Epipharyngitis .
17699253	0	Steroid	0,7	IgA_nephropathy	39,54	Steroid	IgA nephropathy	CHEBI:35341	60498	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|END_ENTITY	Steroid treatment for severe childhood IgA_nephropathy : a randomized , controlled trial .
9176394	0	Steroid	0,7	L-plastin	53,62	Steroid	L-plastin	CHEBI:35341	3936	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Steroid hormone induction and expression patterns of L-plastin in normal and carcinomatous prostate tissues .
21395541	0	Steroid	0,7	P450	52,56	Steroid	P450	CHEBI:35341	1555	Chemical	Gene	regulation|amod|START_ENTITY END_ENTITY|nsubj|regulation	Steroid regulation of drug-metabolizing cytochromes P450 .
6685797	0	Steroid	0,7	PA_1	54,58	Steroid	PA 1	CHEBI:35341	79447	Chemical	Gene	metabolism|amod|START_ENTITY END_ENTITY|nsubj|metabolism	Steroid metabolism in human teratocarcinoma cell line PA_1 .
21737465	0	Steroid	0,7	RET	30,33	Steroid	RET	CHEBI:35341	5979	Chemical	Gene	modulation|amod|START_ENTITY modulation|nmod|END_ENTITY	Steroid hormone modulation of RET through two estrogen responsive enhancers in breast_cancer .
23277398	0	Steroid	0,7	SRD5A2	34,40	Steroid	SRD5A2	CHEBI:35341	6716	Chemical	Gene	type|amod|START_ENTITY type|dep|V89L V89L|compound|END_ENTITY	Steroid 5-alpha-reductase type 2 -LRB- SRD5A2 -RRB- V89L and A49T polymorphisms and sporadic prostate_cancer risk : a meta-analysis .
19914946	0	Steroid	0,7	SRD5a2	36,42	Steroid	SRD5a2	CHEBI:35341	6716	Chemical	Gene	reductase|nsubj|START_ENTITY reductase|dobj|Type Type|appos|END_ENTITY	Steroid 5 - -LCB- alpha -RCB- - reductase Type 2 -LRB- SRD5a2 -RRB- gene polymorphisms and risk of prostate_cancer : a HuGE review .
15056284	0	Steroid	0,7	STS	19,22	Steroid	STS	CHEBI:35341	412	Chemical	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Steroid sulfatase -LRB- STS -RRB- expression in the human temporal lobe : enzyme activity , mRNA expression and immunohistochemistry study .
6573129	1	Steroid	87,94	STS	106,109	Steroid	STS	CHEBI:35341	412	Chemical	Gene	sulfatase|amod|START_ENTITY sulfatase|appos|END_ENTITY	Steroid sulfatase -LRB- STS -RRB- is an X-linked enzyme whose locus escapes X inactivation in human somatic cells .
11091733	0	Steroid	16,23	Sulfatase	24,33	Steroid	Sulfatase	CHEBI:35341	347527	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Significance of Steroid Sulfatase Expression in Human Breast_Cancer .
9787257	0	Steroid	0,7	VIP	53,56	Steroid	VIP	CHEBI:35341	7432	Chemical	Gene	Regulation|compound|START_ENTITY Regulation|nmod|Vasoactive_Intestinal_Peptide Vasoactive_Intestinal_Peptide|appos|END_ENTITY	Steroid Regulation of Vasoactive_Intestinal_Peptide -LRB- VIP -RRB- .
9787257	0	Steroid	0,7	Vasoactive_Intestinal_Peptide	22,51	Steroid	Vasoactive Intestinal Peptide	CHEBI:35341	7432	Chemical	Gene	Regulation|compound|START_ENTITY Regulation|nmod|END_ENTITY	Steroid Regulation of Vasoactive_Intestinal_Peptide -LRB- VIP -RRB- .
19297020	0	Steroid	0,7	ZAP-70	19,25	Steroid	ZAP-70	CHEBI:35341	7535	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|END_ENTITY	Steroid effects on ZAP-70 and SYK in relation to apoptosis in poor prognosis chronic_lymphocytic_leukemia .
15028522	0	Steroid	0,7	androgen_receptor	71,88	Steroid	androgen receptor	CHEBI:35341	751774(Tax:59729)	Chemical	Gene	receptors|amod|START_ENTITY receptors|dep|difference difference|nmod|mRNA mRNA|compound|END_ENTITY	Steroid receptors in the adult zebra_finch syrinx : a sex difference in androgen_receptor mRNA , minimal expression of estrogen receptor alpha and aromatase .
15249132	0	Steroid	0,7	androgen_receptor	118,135	Steroid	androgen receptor	CHEBI:35341	367	Chemical	Gene	regulation|amod|START_ENTITY mediated|nsubj|regulation mediated|nmod|END_ENTITY	Steroid hormonal regulation of growth , prostate_specific_antigen secretion , and transcription mediated by the mutated androgen_receptor in CWR22Rv1 human prostate_carcinoma cells .
22449547	0	Steroid	0,7	androgen_receptor	47,64	Steroid	androgen receptor	CHEBI:35341	367	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Steroid derivatives as pure antagonists of the androgen_receptor .
8360187	0	Steroid	0,7	androgen_receptor	24,41	Steroid	androgen receptor	CHEBI:35341	367	Chemical	Gene	requirement|amod|START_ENTITY requirement|nmod|dimerization dimerization|compound|END_ENTITY	Steroid requirement for androgen_receptor dimerization and DNA binding .
12743541	0	Steroid	0,7	angiotensin_II	22,36	Steroid	angiotensin II	CHEBI:35341	24179(Tax:10116)	Chemical	Gene	modulation|amod|START_ENTITY modulation|nmod|action action|amod|END_ENTITY	Steroid modulation of angiotensin_II action in the rat anterior pituitary gland .
5010033	0	Steroid	0,7	blastokinin	19,30	Steroid	blastokinin	CHEBI:35341	7356	Chemical	Gene	START_ENTITY|xcomp|binding binding|xcomp|END_ENTITY	Steroid binding to blastokinin .
2169568	0	Steroid	0,7	calcitonin_gene-related_peptide	22,53	Steroid	calcitonin gene-related peptide	CHEBI:35341	24241(Tax:10116)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Steroid regulation of calcitonin_gene-related_peptide mRNA expression in motoneurons of the spinal_nucleus_of_the_bulbocavernosus .
6527532	0	Steroid	0,7	cytochrome_P-450	26,42	Steroid	cytochrome P-450	CHEBI:35341	4051	Chemical	Gene	interactions|amod|START_ENTITY interactions|nmod|END_ENTITY	Steroid interactions with cytochrome_P-450 from testis microsomes .
22217857	0	Steroid	0,7	cytochrome_P450	50,65	Steroid	cytochrome P450	CHEBI:35341	25251(Tax:10116)	Chemical	Gene	hydroxylation|dep|START_ENTITY hydroxylation|nmod|END_ENTITY	Steroid 11 - hydroxylation by a fungal microsomal cytochrome_P450 .
16288052	0	Steroid	0,7	epidermal_growth_factor	31,54	Steroid	epidermal growth factor	CHEBI:35341	13645(Tax:10090)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Steroid receptor regulation of epidermal_growth_factor signaling through Src_in_breast_and_prostate_cancer cells : steroid antagonist action .
23193535	0	Steroid	0,7	glucocorticoid_receptor	47,70	Steroid	glucocorticoid receptor	CHEBI:35341	2908	Chemical	Gene	resistance|amod|START_ENTITY resistance|dep|role role|nmod|END_ENTITY	Steroid resistance in nasal_polyposis : role of glucocorticoid_receptor and TGF-beta1 .
3012974	0	Steroid	0,7	glucocorticoid_receptor	33,56	Steroid	glucocorticoid receptor	CHEBI:35341	2908	Chemical	Gene	activation|amod|START_ENTITY activation|dep|END_ENTITY	Steroid receptor activation : the glucocorticoid_receptor as a model system .
3304436	0	Steroid	0,7	gonadotropin-releasing_hormone	54,84	Steroid	gonadotropin-releasing hormone	CHEBI:35341	2796	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Steroid feedback inhibition of pulsatile secretion of gonadotropin-releasing_hormone in the ewe .
8721988	0	Steroid	0,7	gonadotropin-releasing_hormone	22,52	Steroid	gonadotropin-releasing hormone	CHEBI:35341	25194(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|regulation regulation|amod|END_ENTITY	Steroid and pulsatile gonadotropin-releasing_hormone -LRB- GnRH -RRB- regulation of luteinizing hormone and GnRH_receptor in a novel gonadotrope cell line .
9053775	0	Steroid	0,7	luteinizing_hormone_releasing_hormone	45,82	Steroid	luteinizing hormone releasing hormone	CHEBI:35341	25194(Tax:10116)	Chemical	Gene	modulation|amod|START_ENTITY modulation|nmod|release release|compound|END_ENTITY	Steroid modulation of neuropeptide Y-induced luteinizing_hormone_releasing_hormone release from median eminence fragments from male rats .
7626465	0	Steroid	0,7	parathyroid_hormone-related_protein	22,57	Steroid	parathyroid hormone-related protein	CHEBI:35341	24695(Tax:10116)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Steroid regulation of parathyroid_hormone-related_protein expression and action in the rat uterus .
10218985	0	Steroid	0,7	progesterone_receptor	22,43	Steroid	progesterone receptor	CHEBI:35341	25154(Tax:10116)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Steroid regulation of progesterone_receptor expression in cultured rat gonadotropes .
16141356	0	Steroid	0,7	progesterone_receptor	115,136	Steroid	progesterone receptor	CHEBI:35341	18667(Tax:10090)	Chemical	Gene	coactivator|amod|START_ENTITY modulate|nsubj|coactivator modulate|dobj|functions functions|nmod|END_ENTITY	Steroid receptor coactivator -LRB- SRC -RRB- -1 and SRC-3 differentially modulate tissue-specific activation functions of the progesterone_receptor .
16728408	0	Steroid	0,7	progesterone_receptor	47,68	Steroid	progesterone receptor	CHEBI:35341	5241	Chemical	Gene	coactivator-3|amod|START_ENTITY required|nsubjpass|coactivator-3 required|nmod|trans-activation trans-activation|compound|END_ENTITY	Steroid receptor coactivator-3 is required for progesterone_receptor trans-activation of target genes in response to gonadotropin-releasing_hormone treatment of pituitary cells .
16813932	0	Steroid	0,7	progesterone_receptor	75,96	Steroid	progesterone receptor	CHEBI:35341	5241	Chemical	Gene	receptors|amod|START_ENTITY receptors|dep|role role|nmod|END_ENTITY	Steroid receptors and mammalian penile development : an unexpected role for progesterone_receptor ?
3216861	0	Steroid	0,7	progesterone_receptor	47,68	Steroid	progesterone receptor	CHEBI:35341	5241	Chemical	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	Steroid hormone-dependent interaction of human progesterone_receptor with its target enhancer element .
7404605	0	Steroid	0,7	progesterone_receptor	51,72	Steroid	progesterone receptor	CHEBI:35341	5241	Chemical	Gene	specificity|amod|START_ENTITY specificity|nmod|END_ENTITY	Steroid binding specificity of the hamster uterine progesterone_receptor .
3345568	0	Steroid	0,7	prolactin	44,53	Steroid	prolactin	CHEBI:35341	24683(Tax:10116)	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|expression expression|compound|END_ENTITY	Steroid receptor-mediated inhibition of rat prolactin gene expression does not require the receptor DNA-binding domain .
9052414	0	Steroid	0,7	prostate-specific_antigen	30,55	Steroid	prostate-specific antigen	CHEBI:35341	354	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Steroid hormone regulation of prostate-specific_antigen gene expression in breast_cancer .
10026121	0	Steroid	0,7	retinol-binding_protein	22,45	Steroid	retinol-binding protein	CHEBI:35341	5950	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Steroid regulation of retinol-binding_protein in the ovine oviduct .
1572282	0	Steroid	0,7	retinol-binding_protein	53,76	Steroid	retinol-binding protein	CHEBI:35341	397124(Tax:9823)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|synthesis synthesis|nmod|END_ENTITY	Steroid regulation of the synthesis and secretion of retinol-binding_protein by the uterus of the pig .
2897361	0	Steroid	0,7	somatostatin	22,34	Steroid	somatostatin	CHEBI:35341	24797(Tax:10116)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|mRNA mRNA|compound|END_ENTITY	Steroid regulation of somatostatin mRNA in the rat hypothalamus .
17064891	0	Steroid	0,7	sulfatase	161,170	Steroid	sulfatase	CHEBI:35341	347527	Chemical	Gene	sulfatase|amod|START_ENTITY _|nsubj|sulfatase _|nmod|activity activity|amod|END_ENTITY	Steroid sulfatase , arylsulfatases A and B , _ galactose-6-sulfatase , and iduronate sulfatase in mammary cells and effects of sulfated and non-sulfated estrogens on sulfatase activity .
17064891	0	Steroid	0,7	sulfatase	80,89	Steroid	sulfatase	CHEBI:35341	347527	Chemical	Gene	sulfatase|amod|START_ENTITY _|nsubj|sulfatase _|dobj|END_ENTITY	Steroid sulfatase , arylsulfatases A and B , _ galactose-6-sulfatase , and iduronate sulfatase in mammary cells and effects of sulfated and non-sulfated estrogens on sulfatase activity .
1840419	0	Steroid	0,7	sulfatase	8,17	Steroid	sulfatase	CHEBI:35341	347527	Chemical	Gene	activities|amod|START_ENTITY activities|compound|END_ENTITY	Steroid sulfatase activities in human leukocytes : biochemical and clinical aspects .
3862670	0	Steroid	0,7	sulfatase	8,17	Steroid	sulfatase	CHEBI:35341	347527	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Steroid sulfatase activity in amnion tissue and amnion cells maintained in monolayer culture .
6594286	0	Steroid	0,7	sulfatase	25,34	Steroid	sulfatase	CHEBI:35341	347527	Chemical	Gene	sulfatase|amod|START_ENTITY C|nsubj|sulfatase C|compound|END_ENTITY	Steroid sulfatase = aryl sulfatase C ?
2177764	0	Steroid_fatty_acid_esters	0,25	ACTH	61,65	Steroid fatty acid esters	ACTH	null	5443	Chemical	Gene	START_ENTITY|dep|effects effects|nmod|END_ENTITY	Steroid_fatty_acid_esters in adrenals and plasma : effects of ACTH .
17629476	0	Steroids	0,8	5alpha-reductase	102,118	Steroids	5alpha-reductase	MESH:D013256	6715	Chemical	Gene	steroid|nsubj|START_ENTITY steroid|xcomp|END_ENTITY	Steroids with a carbamate function at C-17 , a novel class of inhibitors for human and hamster steroid 5alpha-reductase .
24934352	0	Steroids	34,42	Androgen_Receptor	60,77	Steroids	Androgen Receptor	MESH:D013256	367	Chemical	Gene	Target|compound|START_ENTITY Target|dep|END_ENTITY	Novel Nor-Homo - _ and_Spiro-Oxetan - Steroids Target the Human Androgen_Receptor and Act as Antiandrogens .
17629476	0	Steroids	0,8	C-17	38,42	Steroids	C-17	MESH:D013256	54360	Chemical	Gene	START_ENTITY|nmod|function function|nmod|END_ENTITY	Steroids with a carbamate function at C-17 , a novel class of inhibitors for human and hamster steroid 5alpha-reductase .
12193669	0	Steroids	0,8	IL-8	67,71	Steroids	IL-8	MESH:D013256	3576	Chemical	Gene	fail|nsubj|START_ENTITY fail|xcomp|down-regulate down-regulate|dobj|secretion secretion|compound|END_ENTITY	Steroids fail to down-regulate respiratory_syncytial_virus-induced IL-8 secretion in infants .
25847799	0	Steroids	61,69	PFIC-2	87,93	Steroids	PFIC-2	MESH:D013256	8647	Chemical	Gene	START_ENTITY|nmod|Patients Patients|nmod|END_ENTITY	Two Case Reports of Successful Treatment of Cholestasis With Steroids in Patients With PFIC-2 .
19215533	0	Steroids	77,85	Prolactin	22,31	Steroids	Prolactin	MESH:D013256	24683(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|Regulation Regulation|nmod|Expression Expression|compound|END_ENTITY	In vivo Regulation of Prolactin Gene Expression in the Male Rat : Role of Sex Steroids and Dopamine .
2537843	0	Steroids	0,8	corticotropin-releasing_hormone	18,49	Steroids	corticotropin-releasing hormone	MESH:D013256	1392	Chemical	Gene	modulate|nsubj|START_ENTITY modulate|dobj|production production|amod|END_ENTITY	Steroids modulate corticotropin-releasing_hormone production in human fetal membranes and placenta .
1597141	0	Steroids	0,8	prolactin	46,55	Steroids	prolactin	MESH:D013256	280901(Tax:9913)	Chemical	Gene	modulate|nsubj|START_ENTITY modulate|dobj|transdifferentiation transdifferentiation|nmod|cells cells|compound|END_ENTITY	Steroids can modulate transdifferentiation of prolactin and growth hormone cells in bovine pituitary cultures .
16867993	0	Sterol	0,6	ABCG5	19,24	Sterol	ABCG5	CHEBI:15889	27409(Tax:10090)	Chemical	Gene	transfer|nsubj|START_ENTITY transfer|nmod|END_ENTITY	Sterol transfer by ABCG5 and ABCG8 : in vitro assay and reconstitution .
8743048	0	Sterol	0,6	ERG6	51,55	Sterol	ERG6	CHEBI:15889	855003(Tax:4932)	Chemical	Gene	specificity|amod|START_ENTITY specificity|nmod|product product|compound|END_ENTITY	Sterol specificity of the Saccharomyces_cerevisiae ERG6 gene product expressed in Escherichia_coli .
20925360	0	Sterol	0,6	Osh4	52,56	Sterol	Osh4	CHEBI:15889	855958(Tax:4932)	Chemical	Gene	START_ENTITY|nmod|protein protein|amod|END_ENTITY	Sterol binding and membrane lipid attachment to the Osh4 protein of yeast .
16784888	0	Sterol	0,6	TM7SF2	37,43	Sterol	TM7SF2	CHEBI:15889	7108	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Sterol dependent regulation of human TM7SF2 gene expression : role of the encoded 3beta-hydroxysterol Delta14-reductase in human cholesterol biosynthesis .
11939788	0	Sterol	0,6	apolipoprotein_A-I	17,35	Sterol	apolipoprotein A-I	CHEBI:15889	335	Chemical	Gene	efflux|amod|START_ENTITY efflux|nmod|END_ENTITY	Sterol efflux to apolipoprotein_A-I originates from caveolin-rich microdomains and potentiates PDGF-dependent protein kinase activity .
12668685	0	Sterol	0,6	breast_cancer_resistance_protein	30,62	Sterol	breast cancer resistance protein	CHEBI:15889	9429	Chemical	Gene	transport|amod|START_ENTITY transport|nmod|END_ENTITY	Sterol transport by the human breast_cancer_resistance_protein -LRB- ABCG2 -RRB- expressed in Lactococcus_lactis .
25230683	0	Sterol	114,120	erg6	36,40	Sterol	erg6	CHEBI:15889	855003(Tax:4932)	Chemical	Gene	Methyltransferase|compound|START_ENTITY Sterols|dep|Methyltransferase Sterols|nmod|Expressing Expressing|compound|END_ENTITY	Sterols of Saccharomyces_cerevisiae erg6 Knockout Mutant Expressing the Pneumocystis_carinii S-Adenosylmethionine : Sterol C-24 Methyltransferase .
8934451	0	Sterol	0,6	phospholipase_A2	38,54	Sterol	phospholipase A2	CHEBI:15889	151056	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Sterol and steryl_ester regulation of phospholipase_A2 from the mosquito parasite Lagenidium giganteum .
14967816	0	Sterol	0,6	scavenger_receptor_class_B_type_I	21,54	Sterol	scavenger receptor class B type I	CHEBI:15889	20778(Tax:10090)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Sterol regulation of scavenger_receptor_class_B_type_I in macrophages .
26484739	0	Sterols	61,68	P-Glycoprotein	19,33	Sterols	P-Glycoprotein	MESH:D013261	5243	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|Transporter Transporter|compound|END_ENTITY	Interaction of the P-Glycoprotein Multidrug Transporter with Sterols .
17622954	0	Stigmasterol	0,12	FXR	98,101	Stigmasterol	FXR	MESH:D013265	20186(Tax:10090)	Chemical	Gene	antagonist|nsubj|START_ENTITY antagonist|nmod|END_ENTITY	Stigmasterol , a soy lipid-derived phytosterol , is an antagonist of the bile_acid nuclear receptor FXR .
25704082	0	Stimulates	10,20	Glucagon-Like_Peptide_1	32,55	Stimulates	Glucagon-Like Peptide 1	null	2641	Chemical	Gene	Secretion|compound|START_ENTITY Secretion|compound|END_ENTITY	Ezetimibe Stimulates Intestinal Glucagon-Like_Peptide_1 Secretion Via the MEK/ERK Pathway Rather Than Dipeptidyl_Peptidase_4 Inhibition .
14572879	0	Streptozotocin	35,49	GHRH	16,20	Streptozotocin	GHRH	MESH:D013311	29446(Tax:10116)	Chemical	Gene	responses|nmod|START_ENTITY responses|nmod|END_ENTITY	GH responses to GHRH and GHRP-6 in Streptozotocin -LRB- STZ -RRB- - diabetic rats .
12242036	0	Streptozotocin	0,14	O-GlcNAcase	19,30	Streptozotocin	O-GlcNAcase	MESH:D013311	10724	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Streptozotocin , an O-GlcNAcase inhibitor , blunts insulin and growth hormone secretion .
26253631	0	Strongylophorines	0,17	protein_tyrosine_phosphatase_1B	23,54	Strongylophorines	protein tyrosine phosphatase 1B	null	5770	Chemical	Gene	START_ENTITY|appos|inhibitors inhibitors|amod|END_ENTITY	Strongylophorines , new protein_tyrosine_phosphatase_1B inhibitors , from the marine sponge Strongylophora strongilata collected at Iriomote Island .
11033241	0	Styrene	0,7	monoamine_oxidase_A	17,36	Styrene	monoamine oxidase A	MESH:D020058	29253(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Styrene inhibits monoamine_oxidase_A , but not monoamine_oxidase_B in monkey brain mitochondria .
22729783	0	Suberoylanilide_hydroxamic_acid	0,31	RAD51	75,80	Suberoylanilide hydroxamic acid	RAD51	MESH:C111237	5888	Chemical	Gene	START_ENTITY|nmod|modulation modulation|nmod|protein protein|compound|END_ENTITY	Suberoylanilide_hydroxamic_acid as a radiosensitizer through modulation of RAD51 protein and inhibition of homology-directed_repair in multiple_myeloma .
12576549	0	Suberoylanilide_hydroxamic_acid	0,31	histone_deacetylase	35,54	Suberoylanilide hydroxamic acid	histone deacetylase	MESH:C111237	38565(Tax:7227)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Suberoylanilide_hydroxamic_acid , a histone_deacetylase inhibitor , ameliorates motor_deficits in a mouse model of Huntington 's _ disease .
21496451	0	Suberoylanilide_hydroxamic_acid	0,31	histone_deacetylase	42,61	Suberoylanilide hydroxamic acid	histone deacetylase	MESH:C111237	9734	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Suberoylanilide_hydroxamic_acid , a potent histone_deacetylase inhibitor ; its X-ray crystal structure and solid state and solution studies of its Zn -LRB- II -RRB- , Ni -LRB- II -RRB- , Cu -LRB- II -RRB- and Fe -LRB- III -RRB- complexes .
16926151	0	Suberoylanilide_hydroxamic_acid	0,31	p300	72,76	Suberoylanilide hydroxamic acid	p300	MESH:C111237	2033	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Suberoylanilide_hydroxamic_acid induces Akt-mediated phosphorylation of p300 , which promotes acetylation and transcriptional activation of RelA/p65 .
20153964	0	Substituted_fused_bicyclic_pyrrolizinones	0,41	hNK1	73,77	Substituted fused bicyclic pyrrolizinones	hNK1	null	27087	Chemical	Gene	START_ENTITY|nmod|antagonists antagonists|amod|END_ENTITY	Substituted_fused_bicyclic_pyrrolizinones as potent , orally bioavailable hNK1 antagonists .
8896442	0	Suc-Val-Pro-PheP	65,81	cathepsin_G	37,48	Suc-Val-Pro-PheP	cathepsin G	null	1511	Chemical	Gene	complex|nmod|START_ENTITY END_ENTITY|nmod|complex	The 1.8 A crystal structure of human cathepsin_G in complex with Suc-Val-Pro-PheP - -LRB- OPh -RRB- 2 : a Janus-faced proteinase with two opposite specificities .
7182986	0	Succinylacetone	0,15	delta-aminolevulinate_dehydratase	25,58	Succinylacetone	delta-aminolevulinate dehydratase	MESH:C020804	210	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Succinylacetone inhibits delta-aminolevulinate_dehydratase and potentiates the drug and steroid induction of delta-aminolevulinate synthase in liver .
18831933	0	Sucralfate	0,10	uPAR	21,25	Sucralfate	uPAR	MESH:D013392	50692(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|compound|END_ENTITY	Sucralfate modulates uPAR and EGFR expression in an experimental rat model of cervicitis .
15061088	0	Sucrose	0,7	PR-2	39,43	Sucrose	PR-2	MESH:D013395	824893(Tax:3702)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Sucrose increases pathogenesis-related PR-2 gene expression in Arabidopsis_thaliana through an SA-dependent but NPR1-independent signaling pathway .
10557229	0	Sucrose	0,7	WPK4	36,40	Sucrose	WPK4	MESH:D013395	542771(Tax:4565)	Chemical	Gene	Modulation|compound|START_ENTITY Modulation|nmod|END_ENTITY	Sucrose and Cytokinin Modulation of WPK4 , a Gene Encoding a SNF1-Related_Protein_Kinase from Wheat .
10712293	0	Sucrose	0,7	c-Fos	47,52	Sucrose	c-Fos	MESH:D013395	314322(Tax:10116)	Chemical	Gene	consumption|amod|START_ENTITY increases|nsubj|consumption increases|dobj|immunoreactivity immunoreactivity|amod|END_ENTITY	Sucrose consumption increases naloxone-induced c-Fos immunoreactivity in limbic forebrain .
21718761	0	Sucrose	0,7	c-fos	17,22	Sucrose	c-fos	MESH:D013395	314322(Tax:10116)	Chemical	Gene	modifies|nsubj|START_ENTITY modifies|dobj|expression expression|amod|END_ENTITY	Sucrose modifies c-fos mRNA expression in the brain of rats maintained on feeding schedules .
20053992	0	Sucrose_octasulfate	0,19	thrombin	44,52	Sucrose octasulfate	thrombin	MESH:C053081	2147	Chemical	Gene	accelerates|nsubj|START_ENTITY accelerates|dobj|inactivation inactivation|compound|END_ENTITY	Sucrose_octasulfate selectively accelerates thrombin inactivation by heparin_cofactor_II .
15766589	0	Sudan_I	124,131	cytochrome_P450_1A1	14,33	Sudan I	cytochrome P450 1A1	MESH:C024336	1543	Chemical	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of cytochrome_P450_1A1 and its contribution to oxidation of a potential human carcinogen 1-phenylazo-2-naphthol -LRB- Sudan_I -RRB- in human livers .
12231984	0	Sugar	43,48	Acid_Invertase	14,28	Sugar	Acid Invertase	null	543992(Tax:4081)	Chemical	Gene	Composition|compound|START_ENTITY Composition|compound|END_ENTITY	Expression of Acid_Invertase Gene Controls Sugar Composition in Tomato -LRB- Lycopersicon -RRB- Fruit .
15665497	0	Sugar	0,5	AtCIPK14	68,76	Sugar	AtCIPK14	null	831765(Tax:3702)	Chemical	Gene	START_ENTITY|dobj|expression expression|nmod|END_ENTITY	Sugar responsible and tissue specific expression of a gene encoding AtCIPK14 , an Arabidopsis CBL-interacting protein kinase .
6192908	0	Sugar	0,5	alpha-fetoprotein	15,32	Sugar	alpha-fetoprotein	null	174	Chemical	Gene	chain|compound|START_ENTITY chain|nmod|END_ENTITY	Sugar chain of alpha-fetoprotein produced in human yolk sac tumor .
7686446	0	Sugar	0,5	alpha-fetoprotein	33,50	Sugar	alpha-fetoprotein	null	174	Chemical	Gene	chains|compound|START_ENTITY chains|nmod|END_ENTITY	Sugar chains of human cord serum alpha-fetoprotein : characteristics of N-linked sugar chains of glycoproteins produced in human liver_and_hepatocellular_carcinomas .
26795114	0	Sulfamide	0,9	carbonic_anhydrase_VII	37,59	Sulfamide	carbonic anhydrase VII	CHEBI:29368	766	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Sulfamide derivatives with selective carbonic_anhydrase_VII inhibitory action .
8866821	5	Sulfaphenazole	928,942	CYP2C9	968,974	Sulfaphenazole	CYP1A2	MESH:D013426	1544	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Sulfaphenazole , a specific inhibitor of CYP2C9 , reduced the microsomal O-demethylation of R - _ and_S-naproxen by 43 % and 47 % , respectively , and the CYP1A2 inhibitor furafylline decreased R - _ and_S-naproxen_O-demethylation by 38 % and 28 % , respectively .
6142713	0	Sulfasalazine	0,13	N-formyl-methionyl-leucyl-phenylalanine	39,78	Sulfasalazine	N-formyl-methionyl-leucyl-phenylalanine	MESH:D012460	2357	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Sulfasalazine inhibition of binding of N-formyl-methionyl-leucyl-phenylalanine -LRB- FMLP -RRB- to its receptor on human neutrophils .
19234301	0	Sulfasalazine	0,13	haem_oxygenase-1	22,38	Sulfasalazine	haem oxygenase-1	MESH:D012460	24451(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Sulfasalazine induces haem_oxygenase-1 via ROS-dependent Nrf2 signalling , leading to control of neointimal hyperplasia .
15248210	0	Sulfasalazine	0,13	reduced_folate_carrier	43,65	Sulfasalazine	reduced folate carrier	MESH:D012460	6573	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Sulfasalazine is a potent inhibitor of the reduced_folate_carrier : implications for combination therapies with methotrexate in rheumatoid_arthritis .
25919187	0	Sulfate	78,85	OAT4	8,12	Sulfate	OAT4	CHEBI:16189	55867	Chemical	Gene	Uptake|nmod|START_ENTITY END_ENTITY|nmod|Uptake	Role of OAT4 in Uptake of Estriol Precursor 16a-Hydroxydehydroepiandrosterone Sulfate Into Human Placental Syncytiotrophoblasts From Fetus .
26448642	0	Sulfate	48,55	Sulf1	0,5	Sulfate	Sulf1	CHEBI:16189	240725(Tax:10090)	Chemical	Gene	Sulfation|compound|START_ENTITY Sulfation|compound|END_ENTITY	Sulf1 and Sulf2 Differentially Modulate Heparan Sulfate Proteoglycan Sulfation during Postnatal Cerebellum Development : Evidence for Neuroprotective and Neurite Outgrowth Promoting Functions .
26764203	0	Sulfate	8,15	Sulf1	36,41	Sulfate	Sulf1	CHEBI:16189	240725(Tax:10090)	Chemical	Gene	6-O-EndoSulfatases|compound|START_ENTITY 6-O-EndoSulfatases|appos|END_ENTITY	Heparan Sulfate 6-O-EndoSulfatases , Sulf1 and Sulf2 , Regulate Glomerular Integrity by Modulating Growth Factor Signaling .
2820467	0	Sulfate	0,7	angiotensin_converting_enzyme	51,80	Sulfate	angiotensin converting enzyme	CHEBI:16189	1636	Chemical	Gene	potentiation|amod|START_ENTITY potentiation|nmod|END_ENTITY	Sulfate potentiation of the chloride activation of angiotensin_converting_enzyme .
26538444	0	Sulfate	0,7	dPrestin	56,64	Sulfate	dPrestin	CHEBI:16189	39996(Tax:7227)	Chemical	Gene	transport|amod|START_ENTITY transport|nmod|END_ENTITY	Sulfate and thiosulfate inhibit oxalate transport via a dPrestin -LRB- Slc26a6 -RRB- - dependent mechanism in an insect model of calcium_oxalate nephrolithiasis .
9568695	0	Sulfate	0,7	perlecan	59,67	Sulfate	perlecan	CHEBI:16189	313641(Tax:10116)	Chemical	Gene	content|amod|START_ENTITY content|nmod|END_ENTITY	Sulfate content and specific glycosaminoglycan backbone of perlecan are critical for perlecan 's enhancement of islet amyloid polypeptide -LRB- amylin -RRB- fibril formation .
17097222	0	Sulfatide	0,9	adiponectin	20,31	Sulfatide	adiponectin	CHEBI:18318	9370	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Sulfatide increases adiponectin and decreases TNF-alpha , IL-6 , and IL-8 in human adipose_tissue in vitro .
24333181	0	Sulfatide	0,9	miR-223	35,42	Sulfatide	miR-223	CHEBI:18318	407008	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	Sulfatide epigenetically regulates miR-223 and promotes the migration of human hepatocellular_carcinoma cells .
10754306	0	Sulfhydryl	0,10	L-selectin	25,35	Sulfhydryl	L-selectin	null	6402	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Sulfhydryl regulation of L-selectin shedding : phenylarsine_oxide promotes activation-independent L-selectin shedding from leukocytes .
15215814	0	Sulfhydryl	0,10	angiotensin-converting_enzyme	11,40	Sulfhydryl	angiotensin-converting enzyme	null	1636	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|amod|END_ENTITY	Sulfhydryl angiotensin-converting_enzyme inhibition induces sustained reduction of systemic oxidative stress and improves the nitric_oxide pathway in patients with essential_hypertension .
6393990	0	Sulfhydryl	0,10	insulin	32,39	Sulfhydryl	insulin	null	3630	Chemical	Gene	oxidation|amod|START_ENTITY oxidation|nmod|END_ENTITY	Sulfhydryl oxidation of reduced insulin in dilute solution .
26258864	0	Sulfide_Quinone	40,55	SQRDL	72,77	Sulfide Quinone	SQRDL	null	58472	Chemical	Gene	Gene|amod|START_ENTITY Gene|appos|END_ENTITY	Association of the I264T Variant in the Sulfide_Quinone Reductase-Like -LRB- SQRDL -RRB- Gene with Osteoporosis in Korean Postmenopausal Women .
26709389	0	Sulfite	0,7	Cytochrome_c	28,40	Sulfite	Cytochrome c	CHEBI:48854	54205	Chemical	Gene	Activity|compound|START_ENTITY Activity|nmod|END_ENTITY	Sulfite Oxidase Activity of Cytochrome_c : Role of Hydrogen_Peroxide .
19533738	0	Sulfoglucuronosyl_paragloboside	0,31	nuclear_factor_kappaB	126,147	Sulfoglucuronosyl paragloboside	nuclear factor kappaB	MESH:C051917	4790	Chemical	Gene	adhesion|nsubj|START_ENTITY adhesion|dep|regulation regulation|nmod|expression expression|nmod|END_ENTITY	Sulfoglucuronosyl_paragloboside is a ligand for T cell adhesion : regulation of sulfoglucuronosyl_paragloboside expression via nuclear_factor_kappaB signaling .
17643986	0	Sulfonamide	0,11	CB2	52,55	Sulfonamide	CB2	CHEBI:35358	1269	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Sulfonamide derivatives as new potent and selective CB2 cannabinoid receptor agonists .
15050636	0	Sulfonamido	0,11	cyclooxygenase-2	177,193	Sulfonamido	cyclooxygenase-2	null	5743	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|amod|END_ENTITY	Sulfonamido , azidosulfonyl and N-acetylsulfonamido analogues of rofecoxib : 4 - -LSB- 4 - -LRB- N-acetylsulfonamido -RRB- phenyl -RSB- -3 - -LRB- 4-methanesulfonylphenyl -RRB- -2 -LRB- 5H -RRB- furanone is a potent and selective cyclooxygenase-2 inhibitor .
19014884	0	Sulfonamido-aryl_ethers	0,23	bradykinin_B1_receptor	27,49	Sulfonamido-aryl ethers	bradykinin B1 receptor	null	623	Chemical	Gene	START_ENTITY|nmod|antagonists antagonists|amod|END_ENTITY	Sulfonamido-aryl_ethers as bradykinin_B1_receptor antagonists .
18329876	0	Sulfonamidolactam	0,17	factor_Xa	44,53	Sulfonamidolactam	factor Xa	null	2159	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Sulfonamidolactam inhibitors of coagulation factor_Xa .
15553924	0	Sulfonate_ester_hydroxamic_acids	0,32	TACE	71,75	Sulfonate ester hydroxamic acids	TACE	null	6868	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Sulfonate_ester_hydroxamic_acids as potent and selective inhibitors of TACE enzyme .
23047231	0	Sulfonilamidothiopyrimidone	0,27	COX-2	72,77	Sulfonilamidothiopyrimidone	COX-2	null	4513	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|inhibitors inhibitors|compound|END_ENTITY	Sulfonilamidothiopyrimidone and thiopyrimidone derivatives as selective COX-2 inhibitors : synthesis , biological evaluation , and docking studies .
23083016	0	Sulfonyl_fluoride	0,17	fatty_acid_amide_hydrolase	32,58	Sulfonyl fluoride	fatty acid amide hydrolase	MESH:C048899	2166	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Sulfonyl_fluoride inhibitors of fatty_acid_amide_hydrolase .
11815505	0	Sulfonylurea	0,12	insulin	49,56	Sulfonylurea	insulin	CHEBI:26831	3630	Chemical	Gene	inadequacy|compound|START_ENTITY inadequacy|dep|efficacy efficacy|nmod|addition addition|nmod|END_ENTITY	Sulfonylurea inadequacy : efficacy of addition of insulin over 6 years in patients with type 2 diabetes in the U.K. Prospective Diabetes Study -LRB- UKPDS 57 -RRB- .
12475777	0	Sulfonylurea	0,12	insulin	28,35	Sulfonylurea	insulin	CHEBI:26831	3630	Chemical	Gene	stimulation|compound|START_ENTITY stimulation|nmod|secretion secretion|compound|END_ENTITY	Sulfonylurea stimulation of insulin secretion .
17316868	0	Sulfonylurea	0,12	insulin	32,39	Sulfonylurea	insulin	CHEBI:26831	3630	Chemical	Gene	reduce|nsubj|START_ENTITY reduce|dobj|content content|compound|END_ENTITY	Sulfonylurea and glinide reduce insulin content , functional expression of K -LRB- ATP -RRB- channels , and accelerate apoptotic beta-cell death in the chronic phase .
25205223	0	Sulfonylurea	0,12	insulin	111,118	Sulfonylurea	insulin	CHEBI:26831	3630	Chemical	Gene	associated|nsubjpass|START_ENTITY associated|nmod|mortality mortality|nmod|combination combination|nmod|END_ENTITY	Sulfonylurea in combination with insulin is associated with increased mortality compared with a combination of insulin and metformin in a retrospective Danish nationwide study .
25205223	0	Sulfonylurea	0,12	insulin	33,40	Sulfonylurea	insulin	CHEBI:26831	3630	Chemical	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	Sulfonylurea in combination with insulin is associated with increased mortality compared with a combination of insulin and metformin in a retrospective Danish nationwide study .
2946637	0	Sulfonylurea	0,12	insulin	39,46	Sulfonylurea	insulin	CHEBI:26831	3630	Chemical	Gene	therapy|compound|START_ENTITY fails|nsubj|therapy fails|xcomp|diminish diminish|dobj|resistance resistance|compound|END_ENTITY	Sulfonylurea therapy fails to diminish insulin resistance in type I-diabetic subjects .
21977453	0	Sulfonylureas	11,24	Peroxisome_Proliferator-Activated_Receptor_y	28,72	Sulfonylureas	Peroxisome Proliferator-Activated Receptor y	null	5468	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|Activity Activity|compound|END_ENTITY	Effects of Sulfonylureas on Peroxisome_Proliferator-Activated_Receptor_y Activity and on Glucose Uptake by Thiazolidinediones .
17082235	0	Sulfonylureas	0,13	peroxisome_proliferator-activated_receptor_gamma	35,83	Sulfonylureas	peroxisome proliferator-activated receptor gamma	null	5468	Chemical	Gene	START_ENTITY|dep|activity activity|amod|END_ENTITY	Sulfonylureas and glinides exhibit peroxisome_proliferator-activated_receptor_gamma activity : a combined virtual screening and biological assay approach .
17996688	0	Sulforaphane	0,12	COX-2	133,138	Sulforaphane	COX-2	MESH:C016766	19225(Tax:10090)	Chemical	Gene	suppresses|amod|START_ENTITY lipopolysaccharide-induced|nsubj|suppresses lipopolysaccharide-induced|nmod|promoter promoter|compound|END_ENTITY	Sulforaphane suppresses lipopolysaccharide-induced cyclooxygenase-2 -LRB- COX-2 -RRB- expression through the modulation of multiple targets in COX-2 gene promoter .
17996688	0	Sulforaphane	0,12	COX-2	69,74	Sulforaphane	COX-2	MESH:C016766	19225(Tax:10090)	Chemical	Gene	suppresses|amod|START_ENTITY lipopolysaccharide-induced|nsubj|suppresses lipopolysaccharide-induced|dobj|expression expression|appos|END_ENTITY	Sulforaphane suppresses lipopolysaccharide-induced cyclooxygenase-2 -LRB- COX-2 -RRB- expression through the modulation of multiple targets in COX-2 gene promoter .
19287971	0	Sulforaphane	0,12	COX-2	28,33	Sulforaphane	COX-2	MESH:C016766	5743	Chemical	Gene	START_ENTITY|dobj|expression expression|compound|END_ENTITY	Sulforaphane down-regulates COX-2 expression by activating p38 and inhibiting NF-kappaB-DNA-binding activity in human bladder T24 cells .
19013013	0	Sulforaphane	0,12	CYP1A1	21,27	Sulforaphane	CYP1A1	MESH:C016766	13076(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|mRNA mRNA|compound|END_ENTITY	Sulforaphane induces CYP1A1 mRNA , protein , and catalytic activity levels via an AhR-dependent pathway in murine hepatoma Hepa 1c1c7 and human HepG2 cells .
20816911	0	Sulforaphane	0,12	Cyp6a2	41,47	Sulforaphane	Cyp6a2	MESH:C016766	35587(Tax:7227)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	Sulforaphane modulates the expression of Cyp6a2 and Cyp6g1 in larvae of the ST and HB crosses of the Drosophila wing spot test and is genotoxic in the ST cross .
16452234	0	Sulforaphane	0,12	DR5	198,201	Sulforaphane	DR5	MESH:C016766	8795	Chemical	Gene	sensitizes|nsubj|START_ENTITY sensitizes|nmod|up-regulation up-regulation|nmod|END_ENTITY	Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand -LRB- TRAIL -RRB- - resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of DR5 .
26036303	0	Sulforaphane	0,12	EGFR	24,28	Sulforaphane	EGFR	MESH:C016766	1956	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|END_ENTITY	Sulforaphane attenuates EGFR signaling in NSCLC cells .
24952354	0	Sulforaphane	0,12	ERK	39,42	Sulforaphane	ERK	MESH:C016766	5594	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|compound|END_ENTITY	Sulforaphane induces autophagy through ERK activation in neuronal cells .
20166144	0	Sulforaphane	0,12	ERK1/2	113,119	Sulforaphane	ERK1/2	MESH:C016766	5595;5594	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|activation activation|nmod|END_ENTITY	Sulforaphane protects cortical neurons against 5-S-cysteinyl-dopamine-induced toxicity through the activation of ERK1/2 , Nrf-2 and the upregulation of detoxification enzymes .
26498863	0	Sulforaphane	0,12	HIF-1a	38,44	Sulforaphane	HIF-1a	MESH:C016766	3091	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Sulforaphane inhibits hypoxia-induced HIF-1a and VEGF expression and migration of human colon_cancer cells .
24639357	0	Sulforaphane	0,12	IL-23	79,84	Sulforaphane	IL-23	MESH:C016766	83430(Tax:10090)	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|inhibition inhibition|nmod|END_ENTITY	Sulforaphane protects from T cell-mediated autoimmune_disease by inhibition of IL-23 and IL-12 in dendritic cells .
18952368	0	Sulforaphane	0,12	NF-kappaB	57,66	Sulforaphane	NF-kappaB	MESH:C016766	4790	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|activation activation|nmod|END_ENTITY	Sulforaphane suppresses TNF-alpha-mediated activation of NF-kappaB and induces apoptosis through activation of reactive_oxygen_species-dependent caspase-3 .
16516206	0	Sulforaphane	0,12	Nrf2	30,34	Sulforaphane	Nrf2	MESH:C016766	18024(Tax:10090)	Chemical	Gene	START_ENTITY|appos|activator activator|nmod|END_ENTITY	Sulforaphane , an activator of Nrf2 , suppresses cellular accumulation of arsenic and its cytotoxicity in primary mouse hepatocytes .
18755157	0	Sulforaphane	0,12	Nrf2	89,93	Sulforaphane	Nrf2	MESH:C016766	18024(Tax:10090)	Chemical	Gene	suppressed|nsubj|START_ENTITY suppressed|nmod|pathway pathway|amod|END_ENTITY	Sulforaphane suppressed LPS-induced inflammation in mouse peritoneal macrophages through Nrf2 dependent pathway .
19558496	0	Sulforaphane	0,12	Nrf2	105,109	Sulforaphane	Nrf2	MESH:C016766	4780	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Sulforaphane but not ascorbigen , indole-3-carbinole and ascorbic_acid activates the transcription factor Nrf2 and induces phase-2 and antioxidant enzymes in human keratinocytes in culture .
22978402	0	Sulforaphane	0,12	Nrf2	99,103	Sulforaphane	Nrf2	MESH:C016766	18024(Tax:10090)	Chemical	Gene	prevention|amod|START_ENTITY associated|nsubjpass|prevention associated|nmod|up-regulation up-regulation|nmod|END_ENTITY	Sulforaphane prevention of diabetes-induced aortic_damage was associated with the up-regulation of Nrf2 and its down-stream antioxidants .
23416117	0	Sulforaphane	0,12	Nrf2	22,26	Sulforaphane	Nrf2	MESH:C016766	18024(Tax:10090)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Sulforaphane enhances Nrf2 expression in prostate_cancer TRAMP_C1 cells through epigenetic regulation .
24060752	0	Sulforaphane	0,12	Nrf2	21,25	Sulforaphane	Nrf2	MESH:C016766	18024(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Sulforaphane induces Nrf2 and protects against CYP2E1-dependent binge alcohol-induced liver_steatosis .
24707343	0	Sulforaphane	0,12	Nrf2	106,110	Sulforaphane	Nrf2	MESH:C016766	18024(Tax:10090)	Chemical	Gene	attenuation|amod|START_ENTITY associated|nsubjpass|attenuation associated|nmod|upregulation upregulation|nmod|expression expression|amod|END_ENTITY	Sulforaphane attenuation of type 2 diabetes-induced aortic_damage was associated with the upregulation of Nrf2 expression and function .
24801392	0	Sulforaphane	0,12	Nrf2	114,118	Sulforaphane	Nrf2	MESH:C016766	18024(Tax:10090)	Chemical	Gene	reduction|amod|START_ENTITY associated|nsubjpass|reduction associated|nmod|upregulation upregulation|nmod|expression expression|amod|END_ENTITY	Sulforaphane reduction of testicular apoptotic cell death in diabetic mice is associated with the upregulation of Nrf2 expression and function .
25071366	0	Sulforaphane	0,12	Nrf2	103,107	Sulforaphane	Nrf2	MESH:C016766	18024(Tax:10090)	Chemical	Gene	reverses|nsubj|START_ENTITY reverses|nmod|regulation regulation|nmod|pathway pathway|amod|END_ENTITY	Sulforaphane reverses glucocorticoid-induced apoptosis in osteoblastic cells through regulation of the Nrf2 pathway .
25169428	0	Sulforaphane	0,12	Nrf2	128,132	Sulforaphane	Nrf2	MESH:C016766	4780	Chemical	Gene	inhibition|amod|START_ENTITY contributes|nsubj|inhibition contributes|nmod|suppression suppression|nmod|c-Jun c-Jun|nmod|expression expression|amod|END_ENTITY	Sulforaphane inhibition of TPA-mediated PDCD4 downregulation contributes to suppression of c-Jun and induction of p21-dependent Nrf2 expression .
26571201	0	Sulforaphane	0,12	Nrf2	21,25	Sulforaphane	Nrf2	MESH:C016766	18024(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|genes genes|amod|END_ENTITY	Sulforaphane induces Nrf2 target genes and attenuates inflammatory gene expression in microglia from brain of young adult and aged mice .
26583056	0	Sulforaphane	0,12	Nrf2	57,61	Sulforaphane	Nrf2	MESH:C016766	4780	Chemical	Gene	Protects|compound|START_ENTITY Protects|nmod|Activation Activation|compound|END_ENTITY	Sulforaphane Protects against Cardiovascular_Disease via Nrf2 Activation .
26881038	0	Sulforaphane	0,12	Nrf2	36,40	Sulforaphane	Nrf2	MESH:C016766	4780	Chemical	Gene	Activators|amod|START_ENTITY Activators|amod|END_ENTITY	Sulforaphane and Other Nutrigenomic Nrf2 Activators : Can the Clinician 's Expectation Be Matched by the Reality ?
26310710	0	Sulforaphane	0,12	PARP-1	117,123	Sulforaphane	PARP-1	MESH:C016766	142	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Sulforaphane inhibits damage-induced poly _ -LRB- ADP-ribosyl -RRB- ation via direct interaction of its cellular metabolites with PARP-1 .
25070589	0	Sulforaphane	0,12	SKP2	28,32	Sulforaphane	SKP2	MESH:C016766	6502	Chemical	Gene	down-regulates|amod|START_ENTITY END_ENTITY|nsubj|down-regulates	Sulforaphane down-regulates SKP2 to stabilize p27 -LRB- KIP1 -RRB- for inducing antiproliferation in human colon_adenocarcinoma cells .
23195333	0	Sulforaphane	0,12	SLPI	21,25	Sulforaphane	SLPI	MESH:C016766	6590	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|secretion secretion|compound|END_ENTITY	Sulforaphane induces SLPI secretion in the nasal mucosa .
16211562	0	Sulforaphane	0,12	aquaporin-4	22,33	Sulforaphane	aquaporin-4	MESH:C016766	361	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Sulforaphane enhances aquaporin-4 expression and decreases cerebral_edema following traumatic_brain_injury .
20688330	0	Sulforaphane	0,12	endothelial_lipase	22,40	Sulforaphane	endothelial lipase	MESH:C016766	9388	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Sulforaphane inhibits endothelial_lipase expression through NF-kB in endothelial cells .
25016099	0	Sulforaphane	0,12	endothelial_protein_C_receptor	22,52	Sulforaphane	endothelial protein C receptor	MESH:C016766	10544	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Sulforaphane inhibits endothelial_protein_C_receptor shedding in vitro and in vivo .
21116791	0	Sulforaphane	0,12	heme_oxygenase-1	68,84	Sulforaphane	heme oxygenase-1	MESH:C016766	3162	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	Sulforaphane suppresses TARC/CCL17 and MDC/CCL22 expression through heme_oxygenase-1 and NF-kB in human keratinocytes .
22200816	0	Sulforaphane	0,12	heme_oxygenase-1	97,113	Sulforaphane	heme oxygenase-1	MESH:C016766	3162	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|expression expression|nmod|END_ENTITY	Sulforaphane protects against 6-hydroxydopamine-induced cytotoxicity by increasing expression of heme_oxygenase-1 in a PI3K/Akt-dependent manner .
16280330	0	Sulforaphane	0,12	histone_deacetylase	22,41	Sulforaphane	histone deacetylase	MESH:C016766	9734	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Sulforaphane inhibits histone_deacetylase activity in BPH-1 , LnCaP and PC-3 prostate epithelial cells .
16407454	0	Sulforaphane	0,12	histone_deacetylase	22,41	Sulforaphane	histone deacetylase	MESH:C016766	9734	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|tumorigenesis tumorigenesis|amod|END_ENTITY	Sulforaphane inhibits histone_deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice .
23166763	0	Sulforaphane	0,12	microsomal_prostaglandin_E_synthase_1	64,101	Sulforaphane	microsomal prostaglandin E synthase 1	MESH:C016766	9536	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Sulforaphane inhibits prostaglandin_E2 synthesis by suppressing microsomal_prostaglandin_E_synthase_1 .
22427654	0	Sulforaphane	0,12	p21	26,29	Sulforaphane	p21	MESH:C016766	1026	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|expression expression|amod|END_ENTITY	Sulforaphane induction of p21 -LRB- Cip1 -RRB- cyclin-dependent kinase inhibitor expression requires p53 and Sp1 transcription factors and is p53-dependent .
19277846	0	Sulforaphane	0,12	p38_MAP_kinase	54,68	Sulforaphane	p38 MAP kinase	MESH:C016766	1432	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	Sulforaphane inhibits TNF-alpha-induced activation of p38_MAP_kinase and VCAM-1 and MCP-1 expression in endothelial cells .
23153560	0	Sulforaphane	0,12	pregnane_X-receptor	57,76	Sulforaphane	pregnane X-receptor	MESH:C016766	8856	Chemical	Gene	antagonist|nsubj|START_ENTITY antagonist|nmod|END_ENTITY	Sulforaphane is not an effective antagonist of the human pregnane_X-receptor in vivo .
20233902	0	Sulforaphane	0,12	signal_transducer_and_activator_of_transcription_3	75,125	Sulforaphane	signal transducer and activator of transcription 3	MESH:C016766	6774	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	Sulforaphane inhibits constitutive and interleukin-6-induced activation of signal_transducer_and_activator_of_transcription_3 in prostate_cancer cells .
15728556	0	Sulforaphane	0,12	thioredoxin	21,32	Sulforaphane	thioredoxin	MESH:C016766	22166(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Sulforaphane induces thioredoxin through the antioxidant-responsive element and attenuates retinal light damage in mice .
17964119	0	Sulfur	0,6	iNOS	29,33	Sulfur	iNOS	MESH:D013455	4843	Chemical	Gene	downregulates|amod|START_ENTITY END_ENTITY|nsubj|downregulates	Sulfur mustard downregulates iNOS expression to inhibit wound healing in a human keratinocyte model .
17416281	0	Sulindac_sulfone	0,16	beta-catenin	27,39	Sulindac sulfone	beta-catenin	MESH:C025463	1499	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Sulindac_sulfone modulates beta-catenin in human cholesteatoma cell culture .
20332437	0	Sulindac_sulfone	0,16	beta-catenin	39,51	Sulindac sulfone	beta-catenin	MESH:C025463	1499	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|decrease decrease|nmod|END_ENTITY	Sulindac_sulfone induces a decrease of beta-catenin in HNSCC .
11118042	0	Sulindac_sulfone	0,16	cyclooxygenase-2	42,58	Sulindac sulfone	cyclooxygenase-2	MESH:C025463	5743	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Sulindac_sulfone inhibits K-ras-dependent cyclooxygenase-2 expression in human colon_cancer cells .
7640156	0	Sulphasalazine	0,14	thiopurine_methyltransferase	29,57	Sulphasalazine	thiopurine methyltransferase	MESH:D012460	7172	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Sulphasalazine inhibition of thiopurine_methyltransferase : possible mechanism for interaction with 6-mercaptopurine and azathioprine .
716773	2	Sulphate	26,34	growth_hormone	124,138	Sulphate	growth hormone	CHEBI:16189	2688	Chemical	Gene	START_ENTITY|nmod|therapy therapy|amod|END_ENTITY	Sulphate and thymidine incorporation in costal cartilage and somatomedin levels before and during growth_hormone and thyroxine therapy .
20410637	0	Sulphonamides	0,13	protein_tyrosine_phosphatase_1B	31,62	Sulphonamides	protein tyrosine phosphatase 1B	null	5770	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Sulphonamides as inhibitors of protein_tyrosine_phosphatase_1B : a three-dimensional quantitative structure-activity relationship study using self-organizing molecular field analysis approach .
21280976	0	Sulphoraphane	0,13	aquaporin-4	23,34	Sulphoraphane	aquaporin-4	MESH:C573275	11829(Tax:10090)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Sulphoraphane enhances aquaporin-4 expression and decreases spinal_cord_oedema following spinal_cord_injury .
7032805	0	Sulphydryl	0,10	renin	72,77	Sulphydryl	renin	null	403838(Tax:9615)	Chemical	Gene	oxidation|amod|START_ENTITY oxidation|nmod|END_ENTITY	Sulphydryl oxidation in the mechanism of molecular-weight conversion of renin in dog kidney .
7380989	0	Sulpiride	0,9	prolactin	74,83	Sulpiride	prolactin	MESH:D013469	5617	Chemical	Gene	treatment|amod|START_ENTITY treatment|dep|effect effect|nmod|levels levels|nmod|END_ENTITY	Sulpiride treatment during early human pregnancy : effect on the levels of prolactin , six steroids , and placental_lactogen .
19266171	0	Sumatriptan	0,11	calcitonin_gene-related_peptide	28,59	Sumatriptan	calcitonin gene-related peptide	MESH:D018170	796	Chemical	Gene	change|nsubj|START_ENTITY change|dobj|END_ENTITY	Sumatriptan does not change calcitonin_gene-related_peptide in the cephalic and extracephalic circulation in healthy volunteers .
9377591	0	Sumatriptan	0,11	vasopressin	28,39	Sumatriptan	vasopressin	MESH:D018170	551	Chemical	Gene	affect|nsubj|START_ENTITY affect|dobj|secretion secretion|compound|END_ENTITY	Sumatriptan does not affect vasopressin secretion in humans .
27046396	0	Sunitinib	0,9	AChE	58,62	Sunitinib	AChE	MESH:C473478	11423(Tax:10090)	Chemical	Gene	Inhibitor|nsubj|START_ENTITY Inhibitor|compound|END_ENTITY	Sunitinib , a Clinically Used Anticancer Drug , Is a Potent AChE Inhibitor and Attenuates Cognitive_Impairments in Mice .
26815723	0	Sunitinib	0,9	Axl	20,23	Sunitinib	Axl	MESH:C473478	558	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Sunitinib activates Axl signaling in renal_cell_cancer .
26168132	0	Sunitinib	72,81	HIF-1	0,5	Sunitinib	HIF-1	MESH:C473478	3091	Chemical	Gene	Activity|nmod|START_ENTITY Activity|compound|END_ENTITY	HIF-1 Dimerization Inhibitor Acriflavine Enhances Antitumor Activity of Sunitinib in Breast_Cancer_Model .
22261812	0	Sunitinib	0,9	KIT	45,48	Sunitinib	KIT	MESH:C473478	3815	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|mutations mutations|compound|END_ENTITY	Sunitinib therapy for melanoma patients with KIT mutations .
20524040	0	Sunitinib	0,9	PTEN	18,22	Sunitinib	PTEN	MESH:C473478	5728	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Sunitinib induces PTEN expression and inhibits PDGFR signaling and migration of medulloblastoma cells .
25971960	0	Sunitinib	57,66	Receptor_Tyrosine_Kinase	0,24	Sunitinib	Receptor Tyrosine Kinase	MESH:C473478	5979	Chemical	Gene	Response|nmod|START_ENTITY Response|compound|END_ENTITY	Receptor_Tyrosine_Kinase Expression Predicts Response to Sunitinib in Breast_Cancer .
19244102	0	Sunitinib	0,9	Stat3	24,29	Sunitinib	Stat3	MESH:C473478	20848(Tax:10090)	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Sunitinib inhibition of Stat3 induces renal_cell_carcinoma_tumor cell apoptosis and reduces immunosuppressive cells .
17367763	0	Sunitinib	0,9	VEGF	13,17	Sunitinib	VEGF	MESH:C473478	7422	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Sunitinib : a VEGF and PDGF receptor protein kinase and angiogenesis inhibitor .
21817899	0	Sunitinib	135,144	VEGF	0,4	Sunitinib	VEGF	MESH:C473478	7422	Chemical	Gene	treated|nmod|START_ENTITY patients|acl|treated related|nmod|patients related|nsubjpass|expression expression|compound|END_ENTITY	VEGF expression is related to good response and long progression-free survival in gastrointestinal_stromal_tumor patients treated with Sunitinib .
24257372	0	Sunitinib	115,124	VEGF	17,21	Sunitinib	VEGF	MESH:C473478	7422	Chemical	Gene	Treatment|compound|START_ENTITY Dynamics|nmod|Treatment Modeling|nmod|Dynamics Modeling|acl|END_ENTITY	PKPD Modeling of VEGF , sVEGFR-2 , sVEGFR-3 , and sKIT as Predictors of Tumor Dynamics and Overall Survival Following Sunitinib Treatment in GIST .
23626551	0	Sunitinib	32,41	VEGF-VEGFR	10,20	Sunitinib	VEGF-VEGFR	MESH:C473478	7422;3791	Chemical	Gene	Pathway|nmod|START_ENTITY Pathway|compound|END_ENTITY	Targeting VEGF-VEGFR Pathway by Sunitinib in Peripheral_Primitive_Neuroectodermal_Tumor , Paraganglioma and Epithelioid_Hemangioendothelioma : Three Case Reports .
23288144	0	Sunitinib	0,9	aryl_hydrocarbon_receptor	134,159	Sunitinib	aryl hydrocarbon receptor	MESH:C473478	196	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|compound|END_ENTITY	Sunitinib , a tyrosine kinase inhibitor , induces cytochrome_P450_1A1 gene in human breast_cancer MCF7 cells through ligand-independent aryl_hydrocarbon_receptor activation .
26245902	0	Superoxide	194,204	Cytochrome_b	48,60	Superoxide	Cytochrome b	MESH:D013481	4519	Chemical	Gene	Cluster|nmod|START_ENTITY Distribution|nmod|Cluster Affects|dobj|Distribution Affects|nsubj|G167P G167P|nmod|END_ENTITY	Mitochondrial Disease-related Mutation G167P in Cytochrome_b of Rhodobacter_capsulatus Cytochrome_bc1 -LRB- S151P in Human -RRB- Affects the Equilibrium Distribution of -LSB- 2Fe-2S -RSB- Cluster and Generation of Superoxide .
26560496	0	Superoxide	75,85	Endothelial_Nitric_Oxide_Synthase	31,64	Superoxide	Endothelial Nitric Oxide Synthase	MESH:D013481	4846	Chemical	Gene	Generation|compound|START_ENTITY Generation|compound|END_ENTITY	Serine_1179 Phosphorylation of Endothelial_Nitric_Oxide_Synthase Increases Superoxide Generation and Alters Cofactor Regulation .
12126755	0	Superoxide	0,10	Mn-SOD	76,82	Superoxide	Mn-SOD	MESH:D013481	6648	Chemical	Gene	family|amod|START_ENTITY family|appos|END_ENTITY	Superoxide dismutase multigene family : a comparison of the CuZn-SOD -LRB- SOD1 -RRB- , Mn-SOD -LRB- SOD2 -RRB- , and EC-SOD -LRB- SOD3 -RRB- gene structures , evolution , and expression .
14758023	0	Superoxide	0,10	Nox1	25,29	Superoxide	Nox1	MESH:D013481	100735465	Chemical	Gene	generation|amod|START_ENTITY generation|nmod|END_ENTITY	Superoxide generation by Nox1 in guinea_pig gastric mucosal cells involves a component with p67 -LRB- phox -RRB- - ability .
2987422	0	Superoxide	0,10	O-2	18,21	Superoxide	O-2	MESH:D013481	28893	Chemical	Gene	START_ENTITY|dobj|production production|appos|END_ENTITY	Superoxide anion -LRB- O-2 -RRB- production by peripheral blood monocytes in Hodgkin 's _ disease and malignant_lymphoma .
26069236	0	Superoxide	14,24	Protein_C	43,52	Superoxide	Protein C	MESH:D013481	19123(Tax:10090)	Chemical	Gene	Activation|compound|START_ENTITY Activation|compound|END_ENTITY	Deficiency of Superoxide Dismutase Impairs Protein_C Activation and Enhances Susceptibility to Experimental Thrombosis .
833067	0	Superoxide	0,10	SOD	22,25	Superoxide	SOD	MESH:D013481	6647	Chemical	Gene	START_ENTITY|dobj|activity activity|appos|END_ENTITY	Superoxide dismutase -LRB- SOD -RRB- activity in hypoxic mammalian systems .
9625234	0	Superoxide	0,10	SOD	22,25	Superoxide	SOD	MESH:D013481	100135623(Tax:10141)	Chemical	Gene	dismutase|amod|START_ENTITY dismutase|appos|END_ENTITY	Superoxide dismutase -LRB- SOD -RRB- for mustard_gas_burns .
12126755	0	Superoxide	0,10	SOD1	69,73	Superoxide	SOD1	MESH:D013481	6647	Chemical	Gene	family|amod|START_ENTITY family|dep|comparison comparison|nmod|CuZn-SOD CuZn-SOD|appos|END_ENTITY	Superoxide dismutase multigene family : a comparison of the CuZn-SOD -LRB- SOD1 -RRB- , Mn-SOD -LRB- SOD2 -RRB- , and EC-SOD -LRB- SOD3 -RRB- gene structures , evolution , and expression .
25283363	0	Superoxide	15,25	SOD1	38,42	Superoxide	SOD1	MESH:D013481	6647	Chemical	Gene	dismutases|amod|START_ENTITY dismutases|appos|END_ENTITY	Association of Superoxide dismutases -LRB- SOD1 and SOD2 -RRB- and Glutathione_peroxidase_1 -LRB- GPx1 -RRB- gene polymorphisms with Type_2_diabetes_mellitus .
12126755	0	Superoxide	0,10	SOD2	84,88	Superoxide	SOD2	MESH:D013481	6648	Chemical	Gene	family|amod|START_ENTITY family|appos|Mn-SOD Mn-SOD|appos|END_ENTITY	Superoxide dismutase multigene family : a comparison of the CuZn-SOD -LRB- SOD1 -RRB- , Mn-SOD -LRB- SOD2 -RRB- , and EC-SOD -LRB- SOD3 -RRB- gene structures , evolution , and expression .
14654755	0	Superoxide	0,10	angiotensin_II	65,79	Superoxide	angiotensin II	MESH:D013481	183	Chemical	Gene	mediate|nsubj|START_ENTITY mediate|dobj|effects effects|nmod|END_ENTITY	Superoxide does not mediate the acute vasoconstrictor effects of angiotensin_II : a study in human and porcine arteries .
16311928	0	Superoxide	0,10	angiotensin_II	101,115	Superoxide	angiotensin II	MESH:D013481	183	Chemical	Gene	production|amod|START_ENTITY denuded|nsubj|production denuded|dobj|artery artery|acl|stimulated stimulated|nmod|END_ENTITY	Superoxide production and oxygen consumption in endothelium-intact and - denuded artery stimulated by angiotensin_II .
16951043	0	Superoxide	0,10	angiotensin_II	61,75	Superoxide	angiotensin II	MESH:D013481	24179(Tax:10116)	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|dobj|vasoconstriction vasoconstriction|acl|produced produced|nmod|END_ENTITY	Superoxide mediates acute renal vasoconstriction produced by angiotensin_II and catecholamines by a mechanism independent of nitric_oxide .
10420119	0	Superoxide	0,10	catalase	22,30	Superoxide	catalase	MESH:D013481	24248(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|peroxidase peroxidase|amod|END_ENTITY	Superoxide dismutase , catalase , glutathione peroxidase and xanthine oxidase in diabetic rat lenses .
11209763	0	Superoxide	0,10	catalase	46,54	Superoxide	catalase	MESH:D013481	847	Chemical	Gene	reactivates|nsubj|START_ENTITY reactivates|dobj|END_ENTITY	Superoxide reactivates nitric_oxide-inhibited catalase .
11796957	0	Superoxide	0,10	catalase	34,42	Superoxide	catalase	MESH:D013481	24248(Tax:10116)	Chemical	Gene	mimetic|amod|START_ENTITY mimetic|nmod|activity activity|amod|END_ENTITY	Superoxide dismutase mimetic with catalase activity , EUK-134 , attenuates the multiple organ_injury_and_dysfunction caused by endotoxin in the rat .
12353923	0	Superoxide	0,10	catalase	35,43	Superoxide	catalase	MESH:D013481	24248(Tax:10116)	Chemical	Gene	mimetics|amod|START_ENTITY mimetics|nmod|activity activity|amod|END_ENTITY	Superoxide dismutase mimetics with catalase activity reduce the organ injury in hemorrhagic_shock .
12472782	0	Superoxide	0,10	catalase	22,30	Superoxide	catalase	MESH:D013481	24248(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|peroxidase peroxidase|amod|END_ENTITY	Superoxide dismutase , catalase , glutathione peroxidase and NADPH oxidase in lead-induced hypertension .
4357956	0	Superoxide	0,10	catalase	46,54	Superoxide	catalase	MESH:D013481	531682(Tax:9913)	Chemical	Gene	dismutase|amod|START_ENTITY dismutase|dep|contaminant contaminant|nmod|END_ENTITY	Superoxide dismutase : a contaminant of bovine catalase .
6279612	0	Superoxide	0,10	catalase	28,36	Superoxide	catalase	MESH:D013481	847	Chemical	Gene	radical|compound|START_ENTITY inhibits|nsubj|radical inhibits|xcomp|END_ENTITY	Superoxide radical inhibits catalase .
8340930	0	Superoxide	0,10	catalase	26,34	Superoxide	catalase	MESH:D013481	403474(Tax:9615)	Chemical	Gene	dismutase|nsubj|START_ENTITY dismutase|dobj|delays delays|amod|END_ENTITY	Superoxide dismutase plus catalase therapy delays neither cell death nor the loss of the TTC reaction in experimental myocardial_infarction in dogs .
1659916	0	Superoxide	0,10	cytochrome_b	46,58	Superoxide	cytochrome b	MESH:D013481	4519	Chemical	Gene	production|amod|START_ENTITY production|nmod|558 558|compound|END_ENTITY	Superoxide anion production and expression of cytochrome_b 558 by neutrophils are impaired in some patients with myelodysplastic_syndrome .
18790993	0	Superoxide	0,10	eNOS	30,34	Superoxide	eNOS	MESH:D013481	443077(Tax:9940)	Chemical	Gene	restores|amod|START_ENTITY END_ENTITY|nsubj|restores	Superoxide dismutase restores eNOS expression and function in resistance pulmonary arteries from neonatal lambs with persistent_pulmonary_hypertension .
9689061	0	Superoxide	0,10	endothelial_nitric_oxide_synthase	25,58	Superoxide	endothelial nitric oxide synthase	MESH:D013481	4846	Chemical	Gene	generation|amod|START_ENTITY generation|nmod|END_ENTITY	Superoxide generation by endothelial_nitric_oxide_synthase : the influence of cofactors .
7538966	0	Superoxide	0,10	granulocyte_colony-stimulating_factor	102,139	Superoxide	granulocyte colony-stimulating factor	MESH:D013481	1440	Chemical	Gene	production|amod|START_ENTITY treated|nsubj|production treated|nmod|END_ENTITY	Superoxide production by neutrophils in children with malignant_tumors treated with recombinant human granulocyte_colony-stimulating_factor .
7639508	0	Superoxide	0,10	prothymosin_alpha	87,104	Superoxide	prothymosin alpha	MESH:D013481	100506248	Chemical	Gene	generation|amod|START_ENTITY generation|nmod|END_ENTITY	Superoxide anion generation by human peripheral blood mononuclear cells in response to prothymosin_alpha .
10609886	0	Superoxide	0,10	thioredoxin_reductase	51,72	Superoxide	thioredoxin reductase	MESH:D013481	25824	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Superoxide production by dinitrophenyl-derivatized thioredoxin_reductase -- a model for the mechanism and correlation to immunostimulation by dinitrohalobenzenes .
24068474	0	Suramin	0,7	PP5	32,35	Suramin	PP5	MESH:D013498	5536	Chemical	Gene	activator|nsubj|START_ENTITY activator|nmod|activity activity|compound|END_ENTITY	Suramin is a novel activator of PP5 and biphasically modulates S100-activated PP5 activity .
24068474	0	Suramin	0,7	PP5	78,81	Suramin	PP5	MESH:D013498	5536	Chemical	Gene	activator|nsubj|START_ENTITY activator|nmod|activity activity|compound|END_ENTITY	Suramin is a novel activator of PP5 and biphasically modulates S100-activated PP5 activity .
10861758	0	Suramin	0,7	PSM	52,55	Suramin	PSM	MESH:D013498	2346	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	Suramin potently inhibits the enzymatic activity of PSM .
19169647	0	Suramin	0,7	group_IIA_phospholipase_A2	48,74	Suramin	group IIA phospholipase A2	MESH:D013498	5320	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Suramin inhibits macrophage activation by human group_IIA_phospholipase_A2 , but does not affect bactericidal activity of the enzyme .
25281902	0	Suramin	0,7	helicase	17,25	Suramin	helicase	MESH:D013498	164045	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Suramin inhibits helicase activity of NS3 protein of dengue virus in a fluorescence-based high throughput assay format .
9816169	0	Suramin	0,7	p53	18,21	Suramin	p53	MESH:D013498	22060(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|compound|END_ENTITY	Suramin increases p53 protein levels but does not activate the p53-dependent G1 checkpoint .
8509393	0	Suramin	0,7	tumor_necrosis_factor_alpha	43,70	Suramin	tumor necrosis factor alpha	MESH:D013498	7124	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|deoligomerization deoligomerization|nmod|END_ENTITY	Suramin induces deoligomerization of human tumor_necrosis_factor_alpha .
8841939	0	Suramin	0,7	vascular_endothelial_growth_factor	33,67	Suramin	vascular endothelial growth factor	MESH:D013498	7422	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Suramin is a potent inhibitor of vascular_endothelial_growth_factor .
22607367	0	Survivin	0,8	VEGF-C	37,43	Survivin	VEGF-C	null	7424	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Survivin regulates the expression of VEGF-C in lymphatic metastasis of breast_cancer .
24492951	0	Swertiamarin	0,12	IL-1b	78,83	Swertiamarin	IL-1b	MESH:C013270	24494(Tax:10116)	Chemical	Gene	ameliorates|nsubj|START_ENTITY ameliorates|nmod|END_ENTITY	Swertiamarin ameliorates inflammation and osteoclastogenesis intermediates in IL-1b induced rat fibroblast-like synoviocytes .
24780445	0	Syl930	50,56	S1P1	27,31	Syl930	S1P1	null	29733(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	Development of a selective S1P1 receptor agonist , Syl930 , as a potential therapeutic agent for autoimmune_encephalitis .
20557071	0	Symbiopolyol	0,12	VCAM-1	16,22	Symbiopolyol	VCAM-1	MESH:C551655	7412	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Symbiopolyol , a VCAM-1 inhibitor from a symbiotic dinoflagellate of the jellyfish Mastigias papua .
25111027	0	Synephrine	0,10	STAT6	49,54	Synephrine	STAT6	MESH:D013578	6778	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Synephrine inhibits eotaxin-1 expression via the STAT6 signaling pathway .
25111027	0	Synephrine	0,10	eotaxin-1	20,29	Synephrine	eotaxin-1	MESH:D013578	6356	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Synephrine inhibits eotaxin-1 expression via the STAT6 signaling pathway .
19784998	0	Syringetin	0,10	bone_morphogenetic_protein-2	103,131	Syringetin	bone morphogenetic protein-2	MESH:C546494	650	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Syringetin , a flavonoid derivative in grape and wine , induces human osteoblast differentiation through bone_morphogenetic_protein-2 / extracellular_signal-regulated_kinase_1 / 2 pathway .
8375704	0	Szczecin	93,101	PAM	86,89	Szczecin	PAM	null	5066	Chemical	Gene	-RSB-|compound|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- Ovarian_neoplasms in children taken from material of the pediatric children 's clinic PAM in Szczecin -RSB- .
11501940	0	T	26,27	platelet-activating_factor_acetylhydrolase	72,114	T	platelet-activating factor acetylhydrolase	null	5048	Chemical	Gene	polymorphism|compound|START_ENTITY polymorphism|nmod|gene gene|amod|END_ENTITY	Association of a G994 _ -- > _ T -LRB- Val279 _ -- > _ Phe -RRB- polymorphism of the plasma platelet-activating_factor_acetylhydrolase gene with myocardial_damage in Japanese patients with nonfamilial hypertrophic_cardiomyopathy .
25895426	0	T-2_Toxin	20,29	Gonadotropin-releasing_Hormone	46,76	T-2 Toxin	Gonadotropin-releasing Hormone	MESH:D013605	2796	Chemical	Gene	START_ENTITY|nmod|Secretion Secretion|nmod|END_ENTITY	Effects of Low Dose T-2_Toxin on Secretion of Gonadotropin-releasing_Hormone in the Immortalized Hypothalamic GT1-7 Cell Line .
3497853	0	T-2_toxin	48,57	CD-1	61,65	T-2 toxin	CD-1	MESH:D013605	111334(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|compound|END_ENTITY	Effects of low-level long-term oral exposure to T-2_toxin in CD-1 mice .
3722712	0	T-2_toxin	71,80	CD-1	91,95	T-2 toxin	CD-1	MESH:D013605	111334(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|compound|END_ENTITY	Reproductive and teratological effects of continuous low-level dietary T-2_toxin in female CD-1 mice for two generations .
11482541	0	T-2_toxin	14,23	IL-1beta	27,35	T-2 toxin	IL-1beta	MESH:D013605	3553	Chemical	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	The effect of T-2_toxin on IL-1beta and IL-6 secretion in human fetal chondrocytes .
21144892	0	T-2_toxin	11,20	matrix_metalloproteinases	63,88	T-2 toxin	matrix metalloproteinases	MESH:D013605	4322	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of T-2_toxin and selenium on chondrocyte expression of matrix_metalloproteinases -LRB- MMP-1 , MMP-13 -RRB- , a2-macroglobulin -LRB- a2M -RRB- and TIMPs .
9771558	0	T-2_toxin	10,19	monoamine_oxidase	56,73	T-2 toxin	monoamine oxidase	MESH:D013605	29253(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of T-2_toxin on blood-brain barrier permeability monoamine_oxidase activity and protein synthesis in rats .
10411997	0	T-588	11,16	CA1	73,76	T-588	CA1	MESH:C082372	310218(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|neurons neurons|compound|END_ENTITY	Effects of T-588 , a newly synthesized cognitive enhancer , on hippocampal CA1 neurons in rat brain tissue slices .
7914553	0	T-593	36,41	Histamine_H2-receptor	0,21	T-593	Histamine H2-receptor	MESH:C088837	100135540(Tax:10141)	Chemical	Gene	antagonism|nmod|START_ENTITY antagonism|amod|END_ENTITY	Histamine_H2-receptor antagonism of T-593 : studies on positive chronotropic responses in guinea_pig atria .
7650864	0	T-614	0,5	COX-2	97,102	T-614	COX-2	MESH:C077313	5743	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	T-614 , a novel antirheumatic drug , inhibits both the activity and induction of cyclooxygenase-2 -LRB- COX-2 -RRB- in cultured fibroblasts .
12058956	0	T-614	24,29	NF-kappaB	39,48	T-614	NF-kappaB	MESH:C077313	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	An anti-rheumatic agent T-614 inhibits NF-kappaB activation in LPS - and TNF-alpha-stimulated THP-1 cells without interfering with IkappaBalpha degradation .
9253948	0	T-686	0,5	plasminogen_activator_inhibitor-1	28,61	T-686	plasminogen activator inhibitor-1	MESH:C104988	24617(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	T-686 , a novel inhibitor of plasminogen_activator_inhibitor-1 , inhibits thrombosis without impairment_of_hemostasis in rats .
9434261	0	T-686	21,26	plasminogen_activator_inhibitor-1	44,77	T-686	plasminogen activator inhibitor-1	MESH:C104988	18787(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|inhibitor inhibitor|nmod|production production|amod|END_ENTITY	Protective effect of T-686 , an inhibitor of plasminogen_activator_inhibitor-1 production , against the lethal effect of lipopolysaccharide in mice .
9145208	0	T-794	31,36	monoamine_oxidase-A	70,89	T-794	monoamine oxidase-A	MESH:C106442	29253(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|inhibitor inhibitor|nmod|END_ENTITY	Possible therapeutic effect of T-794 , a novel reversible inhibitor of monoamine_oxidase-A , on post-stroke emotional_disturbances , assessed in animal models of depression .
24642720	0	T0070907	0,8	PPAR	12,16	T0070907	PPAR	MESH:C458508	5465	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	T0070907 , a PPAR y inhibitor , induced G2/M arrest enhances the effect of radiation in human cervical_cancer cells through mitotic catastrophe .
23995653	0	T0070907	143,151	PPARy	46,51	T0070907	PPARy	MESH:C458508	5468	Chemical	Gene	induced|nmod|START_ENTITY adipocytes|acl|induced cytotoxicity|nmod|adipocytes Peroxisome_proliferator-activated_receptor_y|dep|cytotoxicity Peroxisome_proliferator-activated_receptor_y|appos|END_ENTITY	Peroxisome_proliferator-activated_receptor_y -LRB- PPARy -RRB- - independent specific cytotoxicity against immature adipocytes induced by PPARy antagonist T0070907 .
24642720	4	T0070907	620,628	PPARy	603,608	T0070907	PPARy	MESH:C458508	5468	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Three cervical_cancer cell lines -LRB- HeLa , SiHa , and Me180 -RRB- were treated with a PPARy inhibitor , T0070907 , and/or radiation .
11877444	0	T0070907	0,8	peroxisome_proliferator-activated_receptor_gamma	33,81	T0070907	peroxisome proliferator-activated receptor gamma	MESH:C458508	5468	Chemical	Gene	START_ENTITY|appos|ligand ligand|nmod|END_ENTITY	T0070907 , a selective ligand for peroxisome_proliferator-activated_receptor_gamma , functions as an antagonist of biochemical and cellular activities .
12923232	0	T0901317	15,23	LXR	4,7	T0901317	LXR	MESH:C423915	22259(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY ligand|ccomp|induces ligand|nsubj|END_ENTITY	The LXR ligand T0901317 induces severe lipogenesis in the db/db diabetic mouse .
19327357	0	T0901317	0,8	LXR	13,16	T0901317	LXR	MESH:C423915	22260(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	T0901317 , an LXR agonist , augments PKA-induced vascular cell calcification .
21602117	0	T0901317	26,34	a-SMA	59,64	T0901317	a-SMA	MESH:C423915	58	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	-LSB- Liver X receptor agonist T0901317 inhibits TGF-b1-induced a-SMA expression in normal human lung fibroblasts -RSB- .
17516158	0	T0901317	10,18	apoE	65,69	T0901317	apoE	MESH:C423915	11816(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|mice mice|amod|END_ENTITY	Effect of T0901317 on hepatic proinflammatory gene expression in apoE - / - mice fed a high-fat/high-cholesterol diet .
18437096	0	T0901317	14,22	apoE	90,94	T0901317	apoE	MESH:C423915	11816(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of T0901317 on ATP-binding_cassette_transporter_A1 and Niemann-Pick_type_C1 in apoE - / - mice .
18785587	0	T0901317	25,33	apoE	69,73	T0901317	apoE	MESH:C423915	11816(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|atherosclerotic_lesions atherosclerotic_lesions|nmod|mice mice|amod|END_ENTITY	Liver_X_receptor agonist T0901317 reduces atherosclerotic_lesions in apoE - / - mice by up-regulating NPC1 expression .
18473193	0	T0901317	50,58	growth_hormone	66,80	T0901317	growth hormone	MESH:C423915	81668(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|hormone hormone|compound|END_ENTITY	Effects of the synthetic liver X receptor agonist T0901317 on the growth_hormone and thyroid hormone axes in male rats .
18330481	0	T0901317	35,43	semicarbazide-sensitive_amine_oxidase	53,90	T0901317	semicarbazide-sensitive amine oxidase	MESH:C423915	11754(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Synthetic liver X receptor agonist T0901317 inhibits semicarbazide-sensitive_amine_oxidase gene expression and activity in apolipoprotein_E knockout mice .
27082844	0	T0901317	12,20	thrombomodulin	33,47	T0901317	thrombomodulin	MESH:C423915	7056	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	LXR agonist T0901317 upregulates thrombomodulin expression in glomerular endothelial cells by inhibition of nuclear factor - kB .
24823391	6	T16Ainh-A01	852,863	ANO1	801,805	T16Ainh-A01	ANO1	MESH:C578466	101772(Tax:10090)	Chemical	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	Knockdown of ANO1 mRNA or incubation with a selective inhibitor T16Ainh-A01 enhanced estradiol production , whereas a selective ANO1 activator Eact significantly inhibited estradiol production in primary cultured GCs .
25253066	4	T19007C	639,646	rs11615	648,655	T19007C	BRCA1/2	null	672;675	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|appos|END_ENTITY	ERCC1 C8092A -LRB- rs3212986 -RRB- and T19007C -LRB- rs11615 -RRB- polymorphisms were genotyped , using an automated sequencing approach .
1517156	0	TA-3037A	0,8	glutathione_S-transferase	29,54	TA-3037A	glutathione S-transferase	MESH:C076479	373156	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	TA-3037A , a new inhibitor of glutathione_S-transferase , produced by actinomycetes .
8365826	0	TA-383	108,114	interleukin_6	118,131	TA-383	interleukin 6	MESH:C083037	16193(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Effect of a novel anti-rheumatic drug , TA-383 , on type II collagen-induced arthritis -- suppressive effect of TA-383 on interleukin_6 production .
8365826	0	TA-383	39,45	interleukin_6	118,131	TA-383	interleukin 6	MESH:C083037	16193(Tax:10090)	Chemical	Gene	drug|appos|START_ENTITY Effect|nmod|drug Effect|dep|effect effect|nmod|TA-383 TA-383|nmod|production production|amod|END_ENTITY	Effect of a novel anti-rheumatic drug , TA-383 , on type II collagen-induced arthritis -- suppressive effect of TA-383 on interleukin_6 production .
1666418	0	TA-6366	27,34	ACE	42,45	TA-6366	ACE	MESH:C065166	24310(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Pharmacological studies on TA-6366 , a new ACE inhibitor : II .
2200918	0	TA-6366	163,170	ACE	179,182	TA-6366	ACE	MESH:C065166	24310(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Pharmacological studies on -LRB- 4S -RRB- -1 - methyl-3 - -LSB- -LRB- 2S -RRB- -2 - -LSB- N - -LRB- -LRB- 1S -RRB- -1 - ethoxycarbonyl-3-phenylpropyl -RRB- amino -RSB- _ propionyl -RSB- -2 - oxo-imidazolidine-4-carboxylic_acid_hydrochloride -LRB- TA-6366 -RRB- , a new ACE inhibitor : I. ACE inhibitory and anti-hypertensive activities .
2200918	0	TA-6366	163,170	ACE	197,200	TA-6366	ACE	MESH:C065166	24310(Tax:10116)	Chemical	Gene	START_ENTITY|dep|inhibitory inhibitory|amod|END_ENTITY	Pharmacological studies on -LRB- 4S -RRB- -1 - methyl-3 - -LSB- -LRB- 2S -RRB- -2 - -LSB- N - -LRB- -LRB- 1S -RRB- -1 - ethoxycarbonyl-3-phenylpropyl -RRB- amino -RSB- _ propionyl -RSB- -2 - oxo-imidazolidine-4-carboxylic_acid_hydrochloride -LRB- TA-6366 -RRB- , a new ACE inhibitor : I. ACE inhibitory and anti-hypertensive activities .
11854288	8	TAB182	1052,1058	tankyrase_1	1122,1133	TAB182	tankyrase 1	null	8658	Chemical	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Like TRF1 , TAB182 binds to the ankyrin domain -LRB- comprising 24 ankyrin repeats -RRB- of tankyrase_1 .
11131666	0	TAC-101	62,69	AP-1	45,49	TAC-101	AP-1	MESH:C112689	3726	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	The induction of apoptosis and inhibition of AP-1 activity by TAC-101 -LRB- 4 - -LSB- 3,5-bis -LRB- trimethylsilyl -RRB- _ benzamido -RSB- _ benzoic_acid -RRB- may result in life prolonging effect in animals bearing metastasizing cancer .
19020730	0	TAE226	0,6	FAK	29,32	TAE226	FAK	MESH:C524632	5747	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	TAE226 , a dual inhibitor for FAK and IGF-IR , has inhibitory effects on mTOR signaling in esophageal_cancer cells .
19030106	0	TAE226	53,59	FAK	26,29	TAE226	FAK	MESH:C524632	5747	Chemical	Gene	complex|nmod|START_ENTITY inhibitors|amod|complex kinase|nmod|inhibitors kinase|compound|END_ENTITY	Crystal structures of the FAK kinase in complex with TAE226 and related bis-anilino_pyrimidine inhibitors reveal a helical DFG conformation .
17219439	0	TAE226	65,71	focal_adhesion_kinase	42,63	TAE226	focal adhesion kinase	MESH:C524632	5747	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|nmod|END_ENTITY	A novel low-molecular weight inhibitor of focal_adhesion_kinase , TAE226 , inhibits glioma growth .
19412184	0	TAG	0,3	TLR4	94,98	TAG	TLR4	null	7099	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	TAG , a splice variant of the adaptor TRAM , negatively regulates the adaptor MyD88-independent TLR4 pathway .
15178368	0	TAK-044	27,34	endothelin-1	63,75	TAK-044	endothelin-1	MESH:C088196	100009270(Tax:9986)	Chemical	Gene	START_ENTITY|nmod|effects effects|acl|END_ENTITY	Differential inhibition by TAK-044 of the inotropic effects of endothelin-1 and endothelin-3 .
9354313	0	TAK-044	44,51	endothelin-1	86,98	TAK-044	endothelin-1	MESH:C088196	1906	Chemical	Gene	antagonist|appos|START_ENTITY produces|nsubj|antagonist produces|dobj|inhibition inhibition|nmod|vasoconstriction vasoconstriction|amod|END_ENTITY	The peptide endothelin receptor antagonist , TAK-044 , produces sustained inhibition of endothelin-1 mediated arteriolar vasoconstriction .
9730434	0	TAK-044	77,84	endothelin-1	14,26	TAK-044	endothelin-1	MESH:C088196	1906	Chemical	Gene	Expression|amod|START_ENTITY Expression|nmod|END_ENTITY	Expression of endothelin-1 and effects of an endothelin receptor antagonist , TAK-044 , at reperfusion after cold preservation in a canine lung transplantation model .
26849714	0	TAK-063	0,7	PDE10A	11,17	TAK-063	PDE10A	MESH:C000594749	63885(Tax:10116)	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|compound|END_ENTITY	TAK-063 , a PDE10A Inhibitor with Balanced Activation of Direct and Indirect Pathways , Provides Potent Antipsychotic-Like Effects in Multiple Paradigms .
26878349	0	TAK-063	45,52	PDE10A	25,31	TAK-063	PDE10A	MESH:C000594749	714983(Tax:9544)	Chemical	Gene	occupancy|nmod|START_ENTITY occupancy|nummod|END_ENTITY	Brain PET measurement of PDE10A occupancy by TAK-063 , a new PDE10A inhibitor , using -LSB- -LRB- 11 -RRB- _ C -RSB- T-773 in nonhuman primates .
26878349	0	TAK-063	45,52	PDE10A	60,66	TAK-063	PDE10A	MESH:C000594749	714983(Tax:9544)	Chemical	Gene	occupancy|nmod|START_ENTITY measurement|nmod|occupancy measurement|appos|inhibitor inhibitor|compound|END_ENTITY	Brain PET measurement of PDE10A occupancy by TAK-063 , a new PDE10A inhibitor , using -LSB- -LRB- 11 -RRB- _ C -RSB- T-773 in nonhuman primates .
25815469	0	TAK-063	57,64	Phosphodiesterase_10A	74,95	TAK-063	Phosphodiesterase 10A	null	63885(Tax:10116)	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|compound|END_ENTITY	Characterization of Binding and Inhibitory Properties of TAK-063 , a Novel Phosphodiesterase_10A Inhibitor .
21218817	0	TAK-100	48,55	dipeptidyl_peptidase_IV	98,121	TAK-100	dipeptidyl peptidase IV	MESH:C575633	1803	Chemical	Gene	Discovery|appos|START_ENTITY Discovery|nmod|inhibitor inhibitor|compound|END_ENTITY	Discovery of a 3-pyridylacetic_acid derivative -LRB- TAK-100 -RRB- as a potent , selective and orally active dipeptidyl_peptidase_IV -LRB- DPP-4 -RRB- inhibitor .
9363795	0	TAK-147	10,17	AChE	27,31	TAK-147	AChE	MESH:C099872	83817(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Effect of TAK-147 , a novel AChE inhibitor , on cerebral energy metabolism .
10027686	0	TAK-147	0,7	acetylcholinesterase	12,32	TAK-147	acetylcholinesterase	MESH:C099872	83817(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	TAK-147 , an acetylcholinesterase inhibitor , increases choline_acetyltransferase activity in cultured rat septal cholinergic neurons .
10637368	0	TAK-147	113,120	acetylcholinesterase	18,38	TAK-147	acetylcholinesterase	MESH:C099872	43	Chemical	Gene	compounds|amod|START_ENTITY relationships|nmod|compounds inhibitor|dep|relationships inhibitor|compound|END_ENTITY	Central selective acetylcholinesterase inhibitor with neurotrophic activity : structure-activity relationships of TAK-147 and related compounds .
9067312	0	TAK-147	127,134	acetylcholinesterase	145,165	TAK-147	acetylcholinesterase	MESH:C099872	83817(Tax:10116)	Chemical	Gene	propanone_fumarate|appos|START_ENTITY propanone_fumarate|appos|inhibitor inhibitor|amod|END_ENTITY	Neurochemical effects of 3 - -LSB- 1 - -LRB- phenylmethyl -RRB- -4 - piperidinyl -RSB- -1 - -LRB- 2,3,4,5-tetrahydro-1H-1-b _ enzazepin-8-yl -RRB- -1 - propanone_fumarate -LRB- TAK-147 -RRB- , a novel acetylcholinesterase inhibitor , in rats .
10027686	0	TAK-147	0,7	choline_acetyltransferase	54,79	TAK-147	choline acetyltransferase	MESH:C099872	290567(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|activity activity|amod|END_ENTITY	TAK-147 , an acetylcholinesterase inhibitor , increases choline_acetyltransferase activity in cultured rat septal cholinergic neurons .
16771730	0	TAK-165	48,55	HER2	6,10	TAK-165	HER2	null	2064	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Novel HER2 selective tyrosine kinase inhibitor , TAK-165 , inhibits bladder , _ kidney_and_androgen-independent_prostate_cancer in vitro and in vivo .
16048963	0	TAK-220	79,86	CCR5	126,130	TAK-220	CCR5	MESH:C506969	1234	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Highly potent inhibition of human_immunodeficiency_virus_type_1 replication by TAK-220 , an orally bioavailable small-molecule CCR5 antagonist .
16048964	0	TAK-220	0,7	CCR5	32,36	TAK-220	CCR5	MESH:C506969	1234	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	TAK-220 , a novel small-molecule CCR5 antagonist , has favorable anti-human immunodeficiency virus interactions with other antiretrovirals in vitro .
16640339	0	TAK-220	57,64	CCR5	40,44	TAK-220	CCR5	MESH:C506969	1234	Chemical	Gene	Discovery|appos|START_ENTITY Discovery|nmod|antagonist antagonist|compound|END_ENTITY	Discovery of a piperidine-4-carboxamide CCR5 antagonist -LRB- TAK-220 -RRB- with highly potent Anti-HIV-1 activity .
26800393	0	TAK-228	0,7	TORC1/2	57,64	TAK-228	TORC1/2	null	23373;200186	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	TAK-228 -LRB- formerly MLN0128 -RRB- , an investigational oral dual TORC1/2 inhibitor : A phase I dose escalation study in patients with relapsed or refractory multiple_myeloma , non-Hodgkin_lymphoma , or Waldenstr m 's macroglobulinemia .
20881006	0	TAK-242	0,7	TLR4	111,115	TAK-242	TLR4	MESH:C507035	7099	Chemical	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	TAK-242 -LRB- resatorvid -RRB- , a small-molecule inhibitor of Toll-like receptor -LRB- TLR -RRB- 4 signaling , binds selectively to TLR4 and interferes with interactions between TLR4 and its adaptor molecules .
24878329	9	TAK-242	1583,1590	TLR4	1563,1567	TAK-242	TLR4	MESH:C507035	7099	Chemical	Gene	blocked|nmod|START_ENTITY blocked|nsubjpass|END_ENTITY	The expression of interleukin _ -LRB- IL -RRB- -6 , IL-8 , and monocyte_chemoattractant_protein-1 were significantly increased in HGECs while challenged with LPS in the context of high glucose ; however , the expression inflammatory cytokines were decreased significantly , whereas TLR4 was blocked by TAK-242 .
26556241	0	TAK-242	0,7	Toll-Like_Receptor_4	11,31	TAK-242	Toll-Like Receptor 4	MESH:C507035	29260(Tax:10116)	Chemical	Gene	START_ENTITY|appos|Antagonist Antagonist|compound|END_ENTITY	TAK-242 , a Toll-Like_Receptor_4 Antagonist , Protects against Aldosterone-Induced Cardiac_and_Renal_Injury .
23050932	0	TAK-242	0,7	Toll-like_receptor_4	39,59	TAK-242	Toll-like receptor 4	MESH:C507035	7099	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|signalling signalling|compound|END_ENTITY	TAK-242 , a small-molecule inhibitor of Toll-like_receptor_4 signalling , unveils similarities and differences in lipopolysaccharide - and lipid-induced inflammation and insulin resistance in muscle cells .
24084220	0	TAK-242	31,38	Toll-like_receptor_4	0,20	TAK-242	Toll-like receptor 4	MESH:C507035	21898(Tax:10090)	Chemical	Gene	treatment|compound|START_ENTITY treatment|amod|END_ENTITY	Toll-like_receptor_4 inhibitor TAK-242 treatment does not influence perfusion recovery in tissue ischemia .
25586141	0	TAK-242	0,7	Toll-like_receptor_4	27,47	TAK-242	Toll-like receptor 4	MESH:C507035	21898(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|nmod|END_ENTITY	TAK-242 , an antagonist for Toll-like_receptor_4 , protects against acute cerebral_ischemia / reperfusion injury in mice .
20664909	0	TAK-442	24,31	thrombin	103,111	TAK-442	thrombin	MESH:C553657	29251(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|inhibitor inhibitor|compound|END_ENTITY	Differential effects of TAK-442 , a novel orally active direct factor Xa inhibitor , and ximelagatran , a thrombin inhibitor , on factor V-mediated feedback on coagulation cascade and bleeding .
12679152	0	TAK-475	26,33	squalene_synthase	37,54	TAK-475	squalene synthase	MESH:C466644	100345480(Tax:9986)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Lipid-lowering effects of TAK-475 , a squalene_synthase inhibitor , in animal models of familial_hypercholesterolemia .
17485025	0	TAK-536	0,7	AT1_receptor	15,27	TAK-536	AT1 receptor	MESH:C521273	11610(Tax:10090)	Chemical	Gene	START_ENTITY|appos|blocker blocker|amod|END_ENTITY	TAK-536 , a new AT1_receptor blocker , improves glucose_intolerance and adipocyte differentiation .
15554077	0	TAK-603	21,28	IFN-gamma	38,47	TAK-603	IFN-gamma	MESH:C104411	3458	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	T helper 1 inhibitor TAK-603 inhibits IFN-gamma and IL-12 production with no effect on IL-18 : an observation in sarcoidosis patients .
16430202	0	TAK-652	0,7	CCR5	17,21	TAK-652	CCR5	MESH:C506967	1234	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	TAK-652 , a novel CCR5 inhibitor , has favourable drug interactions with other antiretrovirals in vitro .
17118998	0	TAK-677	57,64	beta3-adrenoceptor	29,47	TAK-677	beta3-adrenoceptor	MESH:C418363	155	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Lack of an effect of a novel beta3-adrenoceptor agonist , TAK-677 , on energy metabolism in obese individuals : a double-blind , placebo-controlled randomized study .
23856460	0	TAK-700	59,66	CYP17A1	29,36	TAK-700	CYP17A1	MESH:C571806	25146(Tax:10116)	Chemical	Gene	Effect|appos|START_ENTITY Effect|nmod|inhibitor inhibitor|compound|END_ENTITY	Effect of an investigational CYP17A1 inhibitor , orteronel -LRB- TAK-700 -RRB- , on estrogen - and corticoid-synthesis pathways in hypophysectomized female rats and on the serum estradiol levels in female cynomolgus_monkeys .
21310613	0	TAK-733	13,20	MEK	45,48	TAK-733	MEK	MESH:C558666	5609	Chemical	Gene	Discovery|nmod|START_ENTITY inhibitor|nsubj|Discovery inhibitor|nsubj|site site|compound|END_ENTITY	Discovery of TAK-733 , a potent and selective MEK allosteric site inhibitor for the treatment of cancer .
26014721	0	TAK-733	59,66	MEK	44,47	TAK-733	MEK	MESH:C558666	5609	Chemical	Gene	Evaluation|appos|START_ENTITY Evaluation|nmod|efficacy efficacy|nmod|inhibitor inhibitor|compound|END_ENTITY	Evaluation of the therapeutic efficacy of a MEK inhibitor -LRB- TAK-733 -RRB- using -LRB- 18 -RRB- F-fluorodeoxyglucose-positron emission tomography in the human lung xenograft model A549 .
26439693	0	TAK-733	46,53	MEK	31,34	TAK-733	MEK	MESH:C558666	5609	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Antitumor activity of a potent MEK inhibitor , TAK-733 , against colorectal_cancer cell lines and patient derived xenografts .
26918363	0	TAK-733	15,22	MEK	0,3	TAK-733	MEK	MESH:C558666	5609	Chemical	Gene	reduces|nsubj|START_ENTITY affects|parataxis|reduces affects|nsubj|inhibitor inhibitor|compound|END_ENTITY	MEK inhibitor , TAK-733 reduces proliferation , affects cell cycle and apoptosis , and synergizes with other targeted therapies in multiple myeloma .
19064943	0	TAK-778	14,21	estrogen_receptor	83,100	TAK-778	estrogen receptor	MESH:C120450	2099	Chemical	Gene	effect|nmod|START_ENTITY mediated|nsubjpass|effect mediated|nmod|END_ENTITY	The effect of TAK-778 on gene expression of osteoblastic cells is mediated through estrogen_receptor .
21515370	0	TAK-779	72,79	calcineurin_inhibitor	13,34	TAK-779	calcineurin inhibitor	MESH:C119369	94165(Tax:10116)	Chemical	Gene	Effects|amod|START_ENTITY Effects|nmod|END_ENTITY	Effects of a calcineurin_inhibitor , FK506 , and a CCR5/CXCR3 antagonist , TAK-779 , in a rat small intestinal transplantation model .
23358665	0	TAK-901	31,38	Aurora_B	81,89	TAK-901	Aurora B	null	9212	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Biological characterization of TAK-901 , an investigational , novel , multitargeted Aurora_B kinase inhibitor .
22188812	0	TAK-960	0,7	polo-like_kinase_1	59,77	TAK-960	polo-like kinase 1	MESH:C573314	5347	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	TAK-960 , a novel , orally available , selective inhibitor of polo-like_kinase_1 , shows broad-spectrum preclinical antitumor activity in multiple dosing regimens .
23664874	0	TAK-960	13,20	polo-like_kinase_1	70,88	TAK-960	polo-like kinase 1	MESH:C573314	5347	Chemical	Gene	Discovery|nmod|START_ENTITY Discovery|dep|inhibitor inhibitor|nmod|END_ENTITY	Discovery of TAK-960 : an orally available small molecule inhibitor of polo-like_kinase_1 -LRB- PLK1 -RRB- .
26692956	0	TAM	19,22	MiRNA-155	0,9	TAM	MiRNA-155	D013629	406947	Chemical	Gene	resistance|compound|START_ENTITY mediates|dobj|resistance mediates|nsubj|END_ENTITY	MiRNA-155 mediates TAM resistance by modulating SOCS6-STAT3 signalling pathway in breast_cancer .
16140321	3	TAM	561,564	MnSOD	583,588	TAM	MnSOD	null	20656(Tax:10090)	Chemical	Gene	induced|compound|START_ENTITY END_ENTITY|nsubj|induced	TAM treatment induced MnSOD expression in vitro and in vivo .
25567680	0	TAM	0,3	SOCS3	37,42	TAM	SOCS3	null	9021	Chemical	Gene	Regulation|compound|START_ENTITY Regulation|nmod|END_ENTITY	TAM Receptor-Dependent Regulation of SOCS3 and MAPKs Contributes to Proinflammatory Cytokine Downregulation following Chronic NOD2 Stimulation of Human Macrophages .
10619563	0	TAPA	18,22	CD81	24,28	TAPA	CD81	null	25621(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	The expression of TAPA -LRB- CD81 -RRB- correlates with the reactive response of astrocytes in the developing rat CNS .
11156944	7	TAPI	1134,1138	TACE	1142,1146	TAPI	TACE	null	6868	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Exogenous H2O2 mimicked PMA-induced enhancement of ectodomain shedding , and H2O2-induced shedding was blocked by TAPI , a TACE inhibitor .
24452393	0	TAS-114	147,154	dUTPase	128,135	TAS-114	dUTPase	null	34529(Tax:7227)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	First-in-human , phase I dose-escalation study of single and multiple doses of a first-in-class enhancer of fluoropyrimidines , a dUTPase inhibitor -LRB- TAS-114 -RRB- in healthy male volunteers .
22491145	0	TAT-PAK18	27,36	PAK1	11,15	TAT-PAK18	PAK1	null	5058	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	The direct PAK1 inhibitor , TAT-PAK18 , blocks preferentially the growth of human ovarian_cancer cell lines in which PAK1 is abnormally activated by autophosphorylation at Thr 423 .
11390376	0	TATA	63,67	HMG-1	27,32	TATA	HMG-1	null	10354	Chemical	Gene	complex|compound|START_ENTITY END_ENTITY|nmod|complex	The binding interaction of HMG-1 with the TATA-binding_protein / TATA complex .
11390376	0	TATA	63,67	TATA-binding_protein	42,62	TATA	TATA-binding protein	null	6908	Chemical	Gene	complex|compound|START_ENTITY complex|compound|END_ENTITY	The binding interaction of HMG-1 with the TATA-binding_protein / TATA complex .
9425284	0	TATA	19,23	alpha_B-crystallin	0,18	TATA	alpha B-crystallin	null	12955(Tax:10090)	Chemical	Gene	mutations|compound|START_ENTITY mutations|amod|END_ENTITY	alpha_B-crystallin TATA sequence mutations : lens-preference for the proximal TATA box and the distal TATA-like sequence in transgenic_mice .
24125755	0	TAZ	63,66	ERK	51,54	TAZ	ERK	null	5594	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	FGF2 stimulates osteogenic differentiation through ERK induced TAZ expression .
23045390	0	TAZ	0,3	NFAT5	15,20	TAZ	NFAT5	null	10725	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|activity activity|compound|END_ENTITY	TAZ suppresses NFAT5 activity through tyrosine phosphorylation .
14970209	0	TAZ	0,3	TTF-1	19,24	TAZ	TTF-1	null	22130(Tax:10090)	Chemical	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	TAZ interacts with TTF-1 and regulates expression of surfactant protein-C .
1359974	0	TA_2005	82,89	beta_2-adrenoceptor	53,72	TA 2005	beta 2-adrenoceptor	MESH:C074413	281605(Tax:9913)	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Atypical molecular pharmacology of a new long-acting beta_2-adrenoceptor agonist , TA_2005 .
24920241	0	TBA	57,60	antithrombin	23,35	TBA	antithrombin	null	462	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Outstanding effects on antithrombin activity of modified TBA diastereomers containing an optically pure acyclic_nucleotide analogue .
8387748	11	TBA	1464,1467	malondialdehyde	1494,1509	TBA	myeloperoxidase	null	4353	Chemical	Gene	assay|amod|START_ENTITY assay|nmod|END_ENTITY	The TBA assay and other assays of malondialdehyde may be of limited value , therefore , for assessing lipid peroxidation in systems where neutrophils or myeloperoxidase are involved .
23958786	0	TBECH	31,36	androgen_receptor	75,92	TBECH	androgen receptor	null	100005148(Tax:7955)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	The brominated flame retardant TBECH activates the zebrafish -LRB- Danio_rerio -RRB- androgen_receptor , alters gene transcription and causes developmental disturbances .
21486960	0	TBR-652	41,48	CCR5	132,136	TBR-652	CCR5	MESH:C506967	1234	Chemical	Gene	Pharmacokinetics|nmod|START_ENTITY END_ENTITY|nsubj|Pharmacokinetics	Pharmacokinetics and pharmacodynamics of TBR-652 , a novel CCR5 antagonist , in HIV-1-infected , antiretroviral treatment-experienced , CCR5 antagonist-na ve patients .
21486960	0	TBR-652	41,48	CCR5	58,62	TBR-652	CCR5	MESH:C506967	1234	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Pharmacokinetics and pharmacodynamics of TBR-652 , a novel CCR5 antagonist , in HIV-1-infected , antiretroviral treatment-experienced , CCR5 antagonist-na ve patients .
26012743	0	TC-2559	0,7	CCL3	88,92	TC-2559	CCL3	MESH:C419442	20302(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|nmod|END_ENTITY	TC-2559 , an a4b2 nicotinic acetylcholine receptor agonist , suppresses the expression of CCL3 and IL-1b through STAT3 inhibition in cultured murine macrophages .
19482012	0	TC-5619	0,7	alpha7	12,18	TC-5619	alpha7	MESH:C543641	16404(Tax:10090)	Chemical	Gene	START_ENTITY|dep|agonist agonist|amod|END_ENTITY	TC-5619 : an alpha7 neuronal nicotinic receptor-selective agonist that demonstrates efficacy in animal models of the positive and negative symptoms and cognitive_dysfunction of schizophrenia .
16749545	0	TCA	68,71	FAB	60,63	TCA	FAB	CHEBI:30956	2187	Chemical	Gene	toxicity|compound|START_ENTITY END_ENTITY|nmod|toxicity	A preliminary study of tricyclic antidepressant -LRB- TCA -RRB- ovine FAB for TCA toxicity .
21294199	0	TCAQ	26,30	TTF	19,22	TCAQ	TTF	null	399	Chemical	Gene	system|amod|START_ENTITY END_ENTITY|dep|system	A fully conjugated TTF - - TCAQ system : synthesis , structure , and electronic properties .
15757244	0	TCATCT	57,63	calpain-3	89,98	TCATCT	calpain-3	null	825	Chemical	Gene	mutation|compound|START_ENTITY mutation|nmod|gene gene|amod|END_ENTITY	A common haplotype associated with the Basque 2362AG _ -- > _ TCATCT mutation in the muscular calpain-3 gene .
24844635	0	TCB-2	34,39	5-HT2A	14,20	TCB-2	5-HT2A	null	3356	Chemical	Gene	receptors|nmod|START_ENTITY receptors|nummod|END_ENTITY	Activation of 5-HT2A receptors by TCB-2 induces recurrent oscillatory burst discharge in layer 5 pyramidal neurons of the mPFC in vitro .
12573486	0	TCDD	61,65	AhR	19,22	TCDD	AhR	MESH:D013749	196	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Functional role of AhR in the expression of toxic effects by TCDD .
16552988	0	TCDD	88,92	AhR	135,138	TCDD	AhR	MESH:D013749	396654(Tax:9823)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|nmod|END_ENTITY	Aromatic_hydrocarbon_receptor -LRB- AhR -RRB- in the porcine theca and granulosa cells : effect of TCDD , PCB_126 and PCB_153 on the expression of AhR .
26154658	0	TCDD	16,20	AhR	4,7	TCDD	AhR	MESH:D013749	196	Chemical	Gene	Ligand|appos|START_ENTITY Ligand|compound|END_ENTITY	The AhR Ligand , TCDD , Regulates Androgen_Receptor Activity Differently in Androgen-Sensitive versus Castration-Resistant Human Prostate Cancer Cells .
24927102	0	TCDD	0,4	Akt	81,84	TCDD	Akt	MESH:D013749	207	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|activation activation|nmod|END_ENTITY	TCDD promotes lung_tumors via attenuation of apoptosis through activation of the Akt and ERK1/2 signaling pathways .
16552988	0	TCDD	88,92	Aromatic_hydrocarbon_receptor	0,29	TCDD	Aromatic hydrocarbon receptor	MESH:D013749	396654(Tax:9823)	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|dep|effect	Aromatic_hydrocarbon_receptor -LRB- AhR -RRB- in the porcine theca and granulosa cells : effect of TCDD , PCB_126 and PCB_153 on the expression of AhR .
10910992	0	TCDD	15,19	CD4	85,88	TCDD	CD4	MESH:D013749	12504(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|dep|effects	The effects of TCDD on the activation of ovalbumin -LRB- OVA -RRB- - specific DO11 .10 transgenic CD4 -LRB- + -RRB- T cells in adoptively transferred mice .
11750091	0	TCDD	50,54	CD4	95,98	TCDD	CD4	MESH:D013749	12504(Tax:10090)	Chemical	Gene	2,3,7,8-tetrachlorodibenzo-p-dioxin|appos|START_ENTITY Mechanism|nmod|2,3,7,8-tetrachlorodibenzo-p-dioxin Mechanism|dep|decrease decrease|nmod|T T|compound|END_ENTITY	Mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- - induced decrease in anti-CD3-activated CD4 -LRB- + -RRB- T cells : the roles of apoptosis , Fas , and TNF .
12490139	0	TCDD	116,120	CD4	146,149	TCDD	CD4	MESH:D013749	12504(Tax:10090)	Chemical	Gene	2,3,7,8-tetrachlorodibenzo-p-dioxin|appos|START_ENTITY targets|nmod|2,3,7,8-tetrachlorodibenzo-p-dioxin aryl_hydrocarbon_receptor|dep|targets aryl_hydrocarbon_receptor|dep|expression expression|nmod|+ +|compound|END_ENTITY	T lymphocytes are direct , aryl_hydrocarbon_receptor -LRB- AhR -RRB- - dependent targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- : AhR expression in both CD4 + and CD8 + T cells is necessary for full suppression of a cytotoxic T lymphocyte response by TCDD .
12490139	0	TCDD	242,246	CD4	146,149	TCDD	CD4	MESH:D013749	12504(Tax:10090)	Chemical	Gene	necessary|nmod|START_ENTITY necessary|nsubj|aryl_hydrocarbon_receptor aryl_hydrocarbon_receptor|dep|expression expression|nmod|+ +|compound|END_ENTITY	T lymphocytes are direct , aryl_hydrocarbon_receptor -LRB- AhR -RRB- - dependent targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- : AhR expression in both CD4 + and CD8 + T cells is necessary for full suppression of a cytotoxic T lymphocyte response by TCDD .
10739741	0	TCDD	0,4	CYP1A4	13,19	TCDD	CYP1A4	MESH:D013749	396052(Tax:9031)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	TCDD induces CYP1A4 and CYP1A5 in chick liver and kidney and only CYP1A4 , an enzyme lacking arachidonic_acid epoxygenase activity , in myocardium and vascular endothelium .
9630459	0	TCDD	37,41	CYP1A4	224,230	TCDD	CYP1A4	MESH:D013749	396052(Tax:9031)	Chemical	Gene	2,3,7,8-tetrachlorodibenzo-p-dioxin|appos|START_ENTITY induces|nsubj|2,3,7,8-tetrachlorodibenzo-p-dioxin induces|ccomp|arachidonic_acid arachidonic_acid|nmod|END_ENTITY	2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- induces hepatic cytochrome P450-dependent arachidonic_acid epoxygenation in diverse avian orders : regioisomer selectivity and immunochemical comparison of the TCDD-induced P450s to CYP1A4 and 1A5 .
19324859	0	TCDD	126,130	CYP1B1	105,111	TCDD	CYP1B1	MESH:D013749	1545	Chemical	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Expression of cytochrome P450 -LRB- CYP -RRB- enzymes in human nonpigmented ciliary epithelial cells : induction of CYP1B1 expression by TCDD .
2481744	0	TCDD	11,15	EGF	23,26	TCDD	EGF	MESH:D013749	13645(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|receptor receptor|compound|END_ENTITY	Effects of TCDD on the EGF receptor of XB mouse keratinizing epithelial cells .
26953171	0	TCDD	66,70	Epidermal_Growth_Factor_Receptor	0,32	TCDD	Epidermal Growth Factor Receptor	MESH:D013749	1956	Chemical	Gene	Synergize|nmod|START_ENTITY Synergize|compound|END_ENTITY	Epidermal_Growth_Factor_Receptor Kinase Inhibitors Synergize with TCDD to Induce CYP1A1/1A2 in Human Breast Epithelial MCF10A Cells .
15459018	0	TCDD	0,4	Mdm2	15,19	TCDD	Mdm2	MESH:D013749	314856(Tax:10116)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	TCDD activates Mdm2 and attenuates the p53 response to DNA damaging agents .
18617548	0	TCDD	56,60	aryl_hydrocarbon_receptor	15,40	TCDD	aryl hydrocarbon receptor	MESH:D013749	196	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	A role for the aryl_hydrocarbon_receptor and the dioxin TCDD in rheumatoid_arthritis .
25797602	0	TCDD	0,4	aryl_hydrocarbon_receptor	48,73	TCDD	aryl hydrocarbon receptor	MESH:D013749	196	Chemical	Gene	START_ENTITY|nmod|pathway pathway|compound|END_ENTITY	TCDD and omeprazole prime platelets through the aryl_hydrocarbon_receptor -LRB- AhR -RRB- non-genomic pathway .
15897893	0	TCDD	0,4	c-jun	13,18	TCDD	c-jun	MESH:D013749	3725	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	TCDD induces c-jun expression via a novel Ah -LRB- dioxin -RRB- receptor-mediated p38-MAPK-dependent pathway .
2593129	0	TCDD	0,4	cytochrome_P-450d	75,92	TCDD	cytochrome P-450d	MESH:D013749	24297(Tax:10116)	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	TCDD -LRB- 2,3,7,8-tetrachlorodibenzo-p-dioxin -RRB- is a tight binding inhibitor of cytochrome_P-450d .
7785053	0	TCDD	0,4	epidermal_growth_factor_receptor	25,57	TCDD	epidermal growth factor receptor	MESH:D013749	24329(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	TCDD reduces rat hepatic epidermal_growth_factor_receptor : comparison of binding , immunodetection , and autophosphorylation .
8430419	0	TCDD	47,51	epidermal_growth_factor_receptor	60,92	TCDD	epidermal growth factor receptor	MESH:D013749	100301647(Tax:8022)	Chemical	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- on the epidermal_growth_factor_receptor in hepatic plasma membranes of rainbow_trout .
8470122	0	TCDD	47,51	epidermal_growth_factor_receptor	60,92	TCDD	epidermal growth factor receptor	MESH:D013749	100301647(Tax:8022)	Chemical	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- on the epidermal_growth_factor_receptor in hepatic plasma membranes of rainbow_trout -LRB- Oncorhynchus_mykiss -RRB- .
6466340	0	TCDD	0,4	lipoprotein_lipase	51,69	TCDD	lipoprotein lipase	MESH:D013749	100135570(Tax:10141)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|activity activity|amod|END_ENTITY	TCDD -LRB- 2,3,7,8-tetrachlorodibenzo-p-dioxin -RRB- reduces lipoprotein_lipase activity in the adipose tissue of the guinea_pig .
16682824	0	TCDD	88,92	plasma_glutathione_peroxidase	23,52	TCDD	plasma glutathione peroxidase	MESH:D013749	14778(Tax:10090)	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|expression expression|nmod|END_ENTITY	Enhanced expression of plasma_glutathione_peroxidase in the thymus of mice treated with TCDD and its implication for TCDD-induced thymic atrophy .
7586702	4	TCDM	819,823	CD4	801,804	TCDM	CD4	null	920	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	TNF-alpha and IL-1_beta , proinflammatory cytokines which are both induced by LPS , also down-regulate surface and total CD4 expression in TCDM .
20489726	0	TCN-P	29,34	Akt	44,47	TCN-P	Akt	MESH:C014205	207	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|phosphorylation phosphorylation|compound|END_ENTITY	The Akt activation inhibitor TCN-P inhibits Akt phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membrane .
19272631	2	TCP	446,449	PNP	422,425	TCP	PNP	null	4860	Chemical	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	Although degradation of PNP alone was proved to be inefficient toward the NaNO -LRB- 2 -RRB- - mediated oxidative degradation system , when PNP in combination with TCP was used as the substrate , NaNO -LRB- 2 -RRB- showed relatively high catalytic activity for eradicating both PNP and TCP with molecular oxygen .
17948939	0	TCPOBOP	42,49	Constitutive_androstane_receptor	0,32	TCPOBOP	Constitutive androstane receptor	MESH:C028474	12355(Tax:10090)	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Constitutive_androstane_receptor agonist , TCPOBOP , attenuates_steatohepatitis in the methionine_choline-deficient diet-fed mouse .
7889210	0	TCV-116	36,43	Angiotensin_II	0,14	TCV-116	Angiotensin II	MESH:C077793	183	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	Angiotensin_II receptor antagonist , TCV-116 , prevents myocardial_hypertrophy in spontaneously hypertensive rats .
1435062	0	TCV-116	24,31	angiotensin_II	51,65	TCV-116	angiotensin II	MESH:C077793	183	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Hypotensive activity of TCV-116 , a newly developed angiotensin_II receptor antagonist , in spontaneously hypertensive rats .
7810730	0	TCV-116	62,69	angiotensin_II	26,40	TCV-116	angiotensin II	MESH:C077793	183	Chemical	Gene	administration|amod|START_ENTITY administration|nmod|receptor receptor|amod|END_ENTITY	Chronic administration of angiotensin_II receptor antagonist , TCV-116 , in cardiomyopathic hamsters .
7889192	0	TCV-116	50,57	angiotensin_II	14,28	TCV-116	angiotensin II	MESH:C077793	183	Chemical	Gene	Effects|amod|START_ENTITY Effects|nmod|receptor receptor|amod|END_ENTITY	Effects of an angiotensin_II receptor antagonist , TCV-116 , on insulin sensitivity in fructose-fed rats .
7889200	0	TCV-116	49,56	angiotensin_II	13,27	TCV-116	angiotensin II	MESH:C077793	183	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Effect of an angiotensin_II receptor antagonist , TCV-116 , on rat carotid artery neointimal formation after balloon_injury .
7889207	1	TCV-116	112,119	angiotensin_II	129,143	TCV-116	angiotensin II	MESH:C077793	183	Chemical	Gene	START_ENTITY|appos|receptor receptor|compound|END_ENTITY	Effects of TCV-116 , a novel angiotensin_II receptor antagonist .
8013547	0	TCV-116	76,83	angiotensin_II	13,27	TCV-116	angiotensin II	MESH:C077793	183	Chemical	Gene	Effect|amod|START_ENTITY Effect|nmod|antagonist antagonist|amod|END_ENTITY	Effect of an angiotensin_II receptor antagonist , CV-11974 , and its prodrug , TCV-116 , on production of aldosterone .
8221818	0	TCV-116	57,64	angiotensin_II	21,35	TCV-116	angiotensin II	MESH:C077793	183	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Pilot study of a new angiotensin_II receptor antagonist , TCV-116 : effects of a single oral dose on blood pressure in patients with essential hypertension .
9072428	0	TCV-116	49,56	angiotensin_II	13,27	TCV-116	angiotensin II	MESH:C077793	183	Chemical	Gene	Effect|amod|START_ENTITY Effect|nmod|receptor receptor|amod|END_ENTITY	Effect of an angiotensin_II receptor antagonist , TCV-116 , on neointimal formation following balloon_injury_in_the_SHR_carotid_artery .
11889423	0	TCV-116	0,7	angiotensin_II_type_1_receptor	12,42	TCV-116	angiotensin II type 1 receptor	MESH:C077793	81638(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	TCV-116 , an angiotensin_II_type_1_receptor antagonist , reduces hepatic_ischemia-reperfusion injury in rats .
1294265	0	TCV-309	44,51	PAF	28,31	TCV-309	PAF	MESH:C067430	9768	Chemical	Gene	reduces|nsubj|START_ENTITY inhibitor|ccomp|reduces inhibitor|nsubj|factor factor|appos|END_ENTITY	Platelet activating factor -LRB- PAF -RRB- inhibitor -LRB- TCV-309 -RRB- reduces caerulein - and PAF-induced pancreatitis .
8332959	0	TCV-309	21,28	PAF	169,172	TCV-309	PAF	MESH:C067430	300795(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|role role|nmod|END_ENTITY	Inhibitory effect of TCV-309 , a novel platelet_activating_factor -LRB- PAF -RRB- antagonist , on endotoxin-induced disseminated_intravascular_coagulation in rats : possible role of PAF in tissue factor generation .
8332959	0	TCV-309	21,28	PAF	66,69	TCV-309	PAF	MESH:C067430	300795(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|antagonist antagonist|appos|END_ENTITY	Inhibitory effect of TCV-309 , a novel platelet_activating_factor -LRB- PAF -RRB- antagonist , on endotoxin-induced disseminated_intravascular_coagulation in rats : possible role of PAF in tissue factor generation .
8332959	0	TCV-309	21,28	platelet_activating_factor	38,64	TCV-309	platelet activating factor	MESH:C067430	300795(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|antagonist antagonist|compound|END_ENTITY	Inhibitory effect of TCV-309 , a novel platelet_activating_factor -LRB- PAF -RRB- antagonist , on endotoxin-induced disseminated_intravascular_coagulation in rats : possible role of PAF in tissue factor generation .
15201500	0	TDI	114,117	vascular_endothelial_growth_factor	29,63	TDI	vascular endothelial growth factor	CHEBI:53557	7422	Chemical	Gene	changes|appos|START_ENTITY changes|nmod|END_ENTITY	Acute and chronic changes of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in induced sputum of toluene_diisocyanate -LRB- TDI -RRB- - induced asthma patients .
18196268	0	TEA	3,6	Aquaporin-1	30,41	TEA	Aquaporin-1	MESH:D013662	358	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Is TEA an inhibitor for human Aquaporin-1 ?
18755506	0	TEGDMA	11,17	COX-2	48,53	TEGDMA	COX-2	MESH:C020946	19225(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of TEGDMA and HEMA on the expression of COX-2 and iNOS in cultured murine macrophage cells .
10692504	0	TER_117	58,65	glyoxalase_I	147,159	TER 117	glyoxalase I	MESH:C085408	2739	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	The human glutathione transferase P1-1 specific inhibitor TER_117 designed for overcoming cytostatic-drug resistance is also a strong inhibitor of glyoxalase_I .
25480785	1	TESTOSTERONE	98,110	TRPM8	114,119	TESTOSTERONE	TRPM8	MESH:D013739	79054	Chemical	Gene	EVIDENCE|nmod|START_ENTITY EVIDENCE|nmod|END_ENTITY	FUNCTIONAL EVIDENCE FOR AN IONOTROPIC EFFECT OF TESTOSTERONE ON TRPM8 .
12236849	0	TF-505	41,47	5alpha-reductase	70,86	TF-505	5alpha-reductase	MESH:C106324	6715	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Pharmacokinetics and pharmacodynamics of TF-505 , a novel nonsteroidal 5alpha-reductase inhibitor , in normal subjects treated with single or multiple doses .
20185310	0	TFAP	39,43	cyclooxygenase-1	47,63	TFAP	cyclooxygenase-1	null	5742	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Identification of urine metabolites of TFAP , a cyclooxygenase-1 inhibitor .
20652971	0	TG101209	0,8	JAK2	18,22	TG101209	JAK2	MESH:C522865	3717	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	TG101209 , a novel JAK2 inhibitor , has significant in vitro activity in multiple_myeloma and displays preferential cytotoxicity for CD45 + myeloma cells .
21325979	0	TG101209	32,40	JAK2	14,18	TG101209	JAK2	MESH:C522865	3717	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Inhibition of JAK2 signaling by TG101209 enhances radiotherapy in lung_cancer models .
18394554	0	TG101348	12,20	JAK2	34,38	TG101348	JAK2	MESH:C528327	16452(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Efficacy of TG101348 , a selective JAK2 inhibitor , in treatment of a murine model of JAK2V617F-induced polycythemia vera .
21220608	0	TG101348	23,31	JAK2	45,49	TG101348	JAK2	MESH:C528327	3717	Chemical	Gene	Safety|nmod|START_ENTITY Safety|appos|inhibitor inhibitor|compound|END_ENTITY	Safety and efficacy of TG101348 , a selective JAK2 inhibitor , in myelofibrosis .
18375543	9	TG2	1396,1399	OGD	1417,1420	TG2	TG2	null	7052	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|END_ENTITY	This study demonstrates for the first time that TG2 protects against OGD , interacts with HIF1beta , and attenuates the HIF1 hypoxic response pathway .
22022637	0	TGN-020	34,41	Aquaporin_4	47,58	TGN-020	Aquaporin 4	MESH:C558003	361	Chemical	Gene	Ligand|appos|START_ENTITY Development|nmod|Ligand Development|nmod|Imaging Imaging|compound|END_ENTITY	Development of a Novel Ligand , -LSB- C -RSB- TGN-020 , for Aquaporin_4 Positron Emission Tomography Imaging .
20924629	0	TGN-020	49,56	aquaporin_4	26,37	TGN-020	aquaporin 4	MESH:C558003	361	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Pretreatment with a novel aquaporin_4 inhibitor , TGN-020 , significantly reduces ischemic_cerebral_edema .
22487653	0	TGN1412	58,65	CD28	40,44	TGN1412	CD28	null	940	Chemical	Gene	trial|compound|START_ENTITY trial|compound|END_ENTITY	The storm has cleared : lessons from the CD28 superagonist TGN1412 trial .
17367527	0	THG113	0,6	PGF2alpha_receptor	22,40	THG113	PGF2alpha receptor	null	5737	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	THG113 .31 , a specific PGF2alpha_receptor antagonist , induces human myometrial relaxation and BKCa channel activation .
24029593	0	THI-28	34,40	HMGB1	61,66	THI-28	HMGB1	null	15289(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	A tetrahydroisoquinoline alkaloid THI-28 reduces LPS-induced HMGB1 and diminishes organ_injury in septic mice through p38 and PI3K/Nrf2/HO -1 signals .
24098466	0	THI-56	29,35	iNOS	57,61	THI-56	iNOS	null	18126(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	The heme oxygenase-1 inducer THI-56 negatively regulates iNOS expression and HMGB1 release in LPS-activated RAW 264.7 cells and CLP-induced septic mice .
8955956	0	THIP	24,28	GABA_receptor	79,92	THIP	GABA receptor	MESH:C015542	39054(Tax:7227)	Chemical	Gene	actions|nmod|START_ENTITY actions|nmod|END_ENTITY	pH-dependent actions of THIP and ZAPA on an ionotropic Drosophila_melanogaster GABA_receptor .
20655213	0	THIQ	37,41	ICAM-1	95,101	THIQ	ICAM-1	null	15894(Tax:10090)	Chemical	Gene	antagonists|appos|START_ENTITY antagonists|compound|END_ENTITY	Discovery of tetrahydroisoquinoline -LRB- THIQ -RRB- derivatives as potent and orally bioavailable LFA-1 / ICAM-1 antagonists .
20655213	0	THIQ	37,41	LFA-1	89,94	THIQ	LFA-1	null	16408(Tax:10090)	Chemical	Gene	antagonists|appos|START_ENTITY antagonists|compound|END_ENTITY	Discovery of tetrahydroisoquinoline -LRB- THIQ -RRB- derivatives as potent and orally bioavailable LFA-1 / ICAM-1 antagonists .
16356194	0	THR0921	0,7	peroxisome_proliferator-activated_receptor_gamma	17,65	THR0921	peroxisome proliferator-activated receptor gamma	null	19016(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	THR0921 , a novel peroxisome_proliferator-activated_receptor_gamma agonist , reduces the severity of collagen-induced_arthritis .
25274607	11	TIIA	1578,1582	Nrf2	1597,1601	TIIA	Nrf2	null	18024(Tax:10090)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Taken together , our results show that TIIA activates the Nrf2 signaling pathway and induces epigenetic demethylation of the CpGs of Nrf2 .
8958701	0	TJ-8117	20,27	TGF-beta_1	32,42	TJ-8117	TGF-beta 1	MESH:C093447	59086(Tax:10116)	Chemical	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of Onpi-to -LRB- TJ-8117 -RRB- on TGF-beta_1 in rats with 5/6 nephrectomized chronic_renal_failure -RSB- .
20930380	0	TJN-331	10,17	transforming_growth_factor-b1	67,96	TJN-331	transforming growth factor-b1	MESH:C554102	59086(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|production production|amod|END_ENTITY	Effect of TJN-331 on anti-Thy1 nephritis in rats via inhibition of transforming_growth_factor-b1 production .
3979438	0	TL_333	0,6	D-1_and_D-2_dopamine_receptors	49,79	TL 333	D-1 and D-2 dopamine receptors	MESH:C044940	25802	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	TL_333 , a benzhydro -LSB- g -RSB- quinoline , stimulates both D-1_and_D-2_dopamine_receptors : implications for the selectivity of LY_141865 towards the D-2 receptor .
21645617	0	TM1	102,105	Dscam	96,101	TM1	Dscam	MESH:C098227	35652(Tax:7227)	Chemical	Gene	isoforms|compound|START_ENTITY isoforms|compound|END_ENTITY	Human down syndrome cell adhesion molecules -LRB- DSCAMs -RRB- are functionally conserved with Drosophila Dscam -LSB- TM1 -RSB- isoforms in controlling neurodevelopment .
18088603	0	TM1	43,46	prion_protein	63,76	TM1	prion protein	MESH:C098227	19122(Tax:10090)	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	The deletion of amino_acids 114-121 in the TM1 domain of mouse prion_protein stabilizes its conformation but does not affect the overall structure .
20018898	0	TM601	37,42	Annexin_A2	0,10	TM601	Annexin A2	MESH:C091539	302	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Annexin_A2 is a molecular target for TM601 , a peptide with tumor-targeting and anti-angiogenic effects .
26402367	0	TMPyP4	0,6	Acetylcholinesterase	69,89	TMPyP4	Acetylcholinesterase	MESH:C021096	11423(Tax:10090)	Chemical	Gene	Inhibitor|nsubj|START_ENTITY Inhibitor|compound|END_ENTITY	TMPyP4 , a Stabilizer of Nucleic Acid Secondary Structure , Is a Novel Acetylcholinesterase Inhibitor .
15250722	0	TMPyP4	92,98	c-MYC	57,62	TMPyP4	c-MYC	MESH:C021096	4609	Chemical	Gene	promoter|nmod|START_ENTITY promoter|amod|END_ENTITY	The dynamic character of the G-quadruplex element in the c-MYC promoter and modification by TMPyP4 .
11205316	0	TNP-470	49,56	TNF	84,87	TNP-470	TNF	MESH:C066515	103694380	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Synergistic effect of the angiogenesis inhibitor TNP-470 and tumor_necrosis_factor -LRB- TNF -RRB- on Bomirski Ab melanoma in hamsters .
7980579	0	TNP-470	71,78	cyclin_D1	15,24	TNP-470	cyclin D1	MESH:C066515	595	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Suppression of cyclin_D1 mRNA expression by the angiogenesis inhibitor TNP-470 -LRB- AGM-1470 -RRB- in vascular endothelial cells .
23480758	0	TNP-470	0,7	methionine_aminopeptidase-2	11,38	TNP-470	methionine aminopeptidase-2	MESH:C066515	10988	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	TNP-470 , a methionine_aminopeptidase-2 inhibitor , inhibits cell proliferation , migration and invasion of human cholangiocarcinoma cells in vitro .
11070090	0	TNP-470	25,32	p53	42,45	TNP-470	p53	MESH:C066515	22060(Tax:10090)	Chemical	Gene	requires|nsubj|START_ENTITY requires|dobj|END_ENTITY	The antiangiogenic agent TNP-470 requires p53 and p21CIP/WAF for endothelial cell growth arrest .
10188911	0	TNP-470	83,90	prostate-specific_antigen	38,63	TNP-470	prostate-specific antigen	MESH:C066515	354	Chemical	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	Increased transcriptional activity of prostate-specific_antigen in the presence of TNP-470 , an angiogenesis inhibitor .
8020141	0	TPA	119,122	AP-1	31,35	TPA	AP-1	CHEBI:61432	2353	Chemical	Gene	irradiation|compound|START_ENTITY altered|nmod|irradiation altered|nsubjpass|Binding Binding|nmod|END_ENTITY	Binding of promoter-associated AP-1 is not altered during induction and subsequent repression of the c-jun promoter by TPA and UV irradiation .
9138088	0	TPA	11,14	AP-1	57,61	TPA	AP-1	CHEBI:61432	3726	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of TPA , bryostatin_1 , and retinoic_acid on PO-B , AP-1 , and AP-2 DNA binding during HL-60 differentiation .
8378084	0	TPA	83,86	CRE-BPa	43,50	TPA	CRE-BPa	CHEBI:61432	9586	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of trans-activating capacity of CRE-BPa by phorbol_ester_tumor promoter TPA .
1382961	7	TPA	1221,1224	ER	1210,1212	TPA	ER	CHEBI:61432	2099	Chemical	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	Our studies show that degradation of ER mRNA by TPA in MCF-7 cells is dependent on ongoing RNA synthesis but not on protein synthesis .
15788229	0	TPA	15,18	MMP-9	30,35	TPA	MMP-9	CHEBI:61432	4318	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|compound|END_ENTITY	Tumor promoter TPA stimulates MMP-9 secretion from human keratinocytes by activation of superoxide-producing NADPH oxidase .
15670752	7	TPA	1240,1243	NF-kappaB	1275,1284	TPA	NF-kappaB	CHEBI:61432	4790	Chemical	Gene	induced|nsubj|START_ENTITY induced|dobj|activation activation|appos|END_ENTITY	In addition , TPA induced nuclear factor-kappaB -LRB- NF-kappaB -RRB- activation , which was shown by increased nuclear translocation of p65 NF-kappaB and degradation of IkappaB-alpha , a NF-kappaB inhibitory protein .
15670752	7	TPA	1240,1243	NF-kappaB	1402,1411	TPA	NF-kappaB	CHEBI:61432	4790	Chemical	Gene	induced|nsubj|START_ENTITY induced|dobj|activation activation|acl:relcl|shown shown|nmod|translocation translocation|nmod|IkappaB-alpha IkappaB-alpha|appos|protein protein|amod|END_ENTITY	In addition , TPA induced nuclear factor-kappaB -LRB- NF-kappaB -RRB- activation , which was shown by increased nuclear translocation of p65 NF-kappaB and degradation of IkappaB-alpha , a NF-kappaB inhibitory protein .
16142309	6	TPA	870,873	NF-kappaB	917,926	TPA	NF-kappaB	CHEBI:61432	4790	Chemical	Gene	cells|nmod|START_ENTITY Treatment|nmod|cells caused|nsubj|Treatment caused|dobj|activation activation|nmod|END_ENTITY	Treatment of HL-60 cells with TPA -LRB- 0.64-3 .2 nM -RRB- caused a rapid activation of NF-kappaB as determined by electrophoresis mobility shift assay -LRB- EMSA -RRB- and immunocytochemistry .
18425496	5	TPA	1249,1252	NF-kappaB	1264,1273	TPA	NF-kappaB	CHEBI:61432	4790	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	There are conflicting reports regarding the effect of TPA and PKC on NF-kappaB .
12376465	0	TPA	75,78	Nur77	14,19	TPA	Nur77	CHEBI:61432	3164	Chemical	Gene	roles|nmod|START_ENTITY roles|nmod|END_ENTITY	Dual roles of Nur77 in selective regulation of apoptosis and cell cycle by TPA and ATRA in gastric_cancer cells .
7628641	0	TPA	67,70	P-glycoprotein	74,88	TPA	P-glycoprotein	CHEBI:61432	5243	Chemical	Gene	START_ENTITY|nmod|function function|amod|END_ENTITY	Cell-specific effects of RAS oncogene and protein kinase C agonist TPA on P-glycoprotein function .
3686356	6	TPA	946,949	PTH	999,1002	TPA	PTH	CHEBI:61432	5741	Chemical	Gene	absence|nmod|START_ENTITY preparations|nmod|absence +|nmod|preparations +|nmod|mmol/L mmol/L|acl|reduced reduced|dobj|release release|compound|END_ENTITY	In ten preparations in the absence of TPA , increasing Ca + + from 0.25 to 2.5 mmol/L reduced PTH release to an average of 39 % of maximal release -LRB- range , 11 % to 67 % -RRB- .
6090210	0	TPA	28,31	PTH	35,38	TPA	PTH	CHEBI:61432	5741	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Effect of the phorbol_ester TPA on PTH secretion .
9932870	0	TPA	10,13	aquaporin_4	17,28	TPA	aquaporin 4	CHEBI:61432	25293(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of TPA on aquaporin_4 mRNA expression in cultured rat astrocytes .
10698257	0	TPA	0,3	connexin_26	45,56	TPA	connexin 26	CHEBI:61432	2706	Chemical	Gene	induced|nsubj|START_ENTITY induced|dobj|expression expression|nmod|END_ENTITY	TPA induced expression and function of human connexin_26 by post-translational mechanisms in stably transfected neuroblastoma cells .
6517947	0	TPA	60,63	glutathione_reductase	9,30	TPA	glutathione reductase	CHEBI:61432	14782(Tax:10090)	Chemical	Gene	activity|dep|START_ENTITY activity|compound|END_ENTITY	Oxidised glutathione_reductase activity in mouse epidermis : TPA induced change and its modulation by vitamin_A .
11303733	0	TPN	0,3	IL-4	14,18	TPN	IL-4	CHEBI:44409	16189(Tax:10090)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|compound|END_ENTITY	TPN decreases IL-4 and IL-10 mRNA expression in lipopolysaccharide stimulated intestinal lamina propria cells but glutamine supplementation preserves the expression .
25667043	6	TPT	1107,1110	p53	1221,1224	TPT	BAX	MESH:C026677	581	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|END_ENTITY	Moreover , TPT as single agent stimulates p53 -LRB- ser15 -RRB- phosphorylation , p53 PARylation and occupancy of the p21WAF promoter by p53 resulting in an increase of p21WAF expression .
24379686	0	TRC210258	0,9	TGR5	19,23	TRC210258	TGR5	null	151306	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	TRC210258 , a novel TGR5 agonist , reduces glycemic and dyslipidemic_cardiovascular risk in animal models of diabesity .
26499137	4	TRG	546,549	gastric_lesions	605,620	TRG	myeloperoxidase	null	303413(Tax:10116)	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|dobj|END_ENTITY	TRG -LRB- 45 mg kg -LRB- -1 -RRB- -RRB- pretreated rats significantly inhibited gastric_lesions by 81.71 % .
1906090	0	TRH	64,67	GH	49,51	TRH	GH	CHEBI:35940	2688	Chemical	Gene	response|acl|START_ENTITY response|compound|END_ENTITY	Early postoperative basal serum GH level and the GH response to TRH in relation to the long-term outcome of surgical treatment for acromegaly : a report on 39 patients .
219872	0	TRH	11,14	GH	34,36	TRH	GH	CHEBI:35940	2688	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|release release|appos|END_ENTITY	-LSB- Effect of TRH on growth_hormone -LRB- GH -RRB- release induced with ACTH -RSB- .
3108068	0	TRH	124,127	GH	160,162	TRH	GH	CHEBI:35940	378781(Tax:9031)	Chemical	Gene	stimulation|appos|START_ENTITY stimulation|nmod|secretion secretion|appos|END_ENTITY	Effects of insulin-like_growth_factor_I -LRB- IGF-I -RRB- on growth_hormone-releasing factor -LRB- GRF -RRB- and thyrotropin-releasing_hormone -LRB- TRH -RRB- stimulation of growth_hormone -LRB- GH -RRB- secretion in the domestic fowl -LRB- Gallus_domesticus -RRB- .
3135504	2	TRH	375,378	GH	428,430	TRH	GH	CHEBI:35940	378781(Tax:9031)	Chemical	Gene	Challenges|nmod|START_ENTITY evoked|nsubj|Challenges evoked|dobj|patterns patterns|nmod|release release|compound|END_ENTITY	Challenges with TRH at intervals of 1 h evoked different patterns of GH release in anesthetized adult chickens dependent upon TRH dosage .
3135504	2	TRH	485,488	GH	428,430	TRH	GH	CHEBI:35940	378781(Tax:9031)	Chemical	Gene	dosage|compound|START_ENTITY dependent|nmod|dosage chickens|amod|dependent evoked|nmod|chickens evoked|dobj|patterns patterns|nmod|release release|compound|END_ENTITY	Challenges with TRH at intervals of 1 h evoked different patterns of GH release in anesthetized adult chickens dependent upon TRH dosage .
6797811	0	TRH	14,17	GH	43,45	TRH	GH	CHEBI:35940	81668(Tax:10116)	Chemical	Gene	Thyroliberin|appos|START_ENTITY induced|nsubj|Thyroliberin induced|dobj|release release|appos|END_ENTITY	Thyroliberin -LRB- TRH -RRB- induced growth_hormone -LRB- GH -RRB- release : test of maturation of hypothalamo-pituitary axis in postnatal rat .
6805079	9	TRH	1293,1296	GH	1218,1220	TRH	GH	CHEBI:35940	2688	Chemical	Gene	challenged|nmod|START_ENTITY patients|acl|challenged 5|nmod|patients increased|nmod|5 showed|parataxis|increased showed|nmod|levels levels|compound|END_ENTITY	Seven patients with increased GH levels who were challenged with L-dopa showed the typical decrease in GH levels found in this condition ; in 5 of these patients , challenged with TRH , GH levels increased .
7853798	7	TRH	849,852	GH	903,905	TRH	GH	CHEBI:35940	2688	Chemical	Gene	administration|compound|START_ENTITY provoked|nsubj|administration provoked|dobj|response response|nmod|END_ENTITY	TRH administration provoked a paradoxical response of GH -LRB- peak > 5 micrograms/liter -RRB- in nine -LRB- 5 CAPD , 2 HD , 2 PreD -RRB- out of 12 patients .
816640	10	TRH	1545,1548	GH	1564,1566	TRH	GH	CHEBI:35940	81668(Tax:10116)	Chemical	Gene	dose|compound|START_ENTITY dose|acl|induced induced|dobj|rise rise|compound|END_ENTITY	In these animals , only the 1.2 mug TRH dose induced a GH rise at 5 and 10 min .
1388690	0	TRH	27,30	Growth_hormone	0,14	TRH	Growth hormone	CHEBI:35940	378781(Tax:9031)	Chemical	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Growth_hormone response to TRH in male broiler chickens selected for body weight_gain or food conversion and reared at either a moderate or a high ambient temperature .
1620073	0	TRH	94,97	Growth_hormone	1,15	TRH	Growth hormone	CHEBI:35940	2688	Chemical	Gene	thyrotropin_releasing_hormone|appos|START_ENTITY administration|nmod|thyrotropin_releasing_hormone secretion|nmod|administration secretion|nsubj|END_ENTITY	-LSB- Growth_hormone secretion in response to the administration of thyrotropin_releasing_hormone -LRB- TRH -RRB- in children with insulin-dependent_diabetes_mellitus -RSB- .
2465936	0	TRH	81,84	Growth_hormone	0,14	TRH	Growth hormone	CHEBI:35940	378781(Tax:9031)	Chemical	Gene	synergy|compound|START_ENTITY culture|dep|synergy cells|nmod|culture cells|dep|release release|amod|END_ENTITY	Growth_hormone release from chicken anterior pituitary cells in primary culture : TRH and hpGRF synergy , protein synthesis , and cyclic_adenosine_3 ' 5 ' - monophosphate .
2126626	0	TRH	33,36	Interleukin_1_beta	0,18	TRH	Interleukin 1 beta	CHEBI:35940	3553	Chemical	Gene	modulation|nmod|START_ENTITY modulation|amod|END_ENTITY	Interleukin_1_beta modulation of TRH stimulated prolactin secretion and inositol_phosphate production .
19289102	5	TRH	763,766	MKP-1	770,775	TRH	MKP-1	CHEBI:35940	114856(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	The effect of TRH on MKP-1 expression was completely prevented in the presence of the MEK inhibitor , U0126 .
10904125	0	TRH	22,25	Prolactin	0,9	TRH	Prolactin	CHEBI:35940	5617	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Prolactin response to TRH in patients with panic_disorder .
111967	0	TRH	22,25	Prolactin	0,9	TRH	Prolactin	CHEBI:35940	5617	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Prolactin response to TRH after intravenous cimetidine .
3086543	0	TRH	22,25	Prolactin	0,9	TRH	Prolactin	CHEBI:35940	5617	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Prolactin response to TRH in depression .
414510	0	TRH	28,31	Prolactin	0,9	TRH	Prolactin	CHEBI:35940	5617	Chemical	Gene	responsiveness|xcomp|START_ENTITY responsiveness|nsubj|END_ENTITY	Prolactin responsiveness to TRH in amenorrheic women with and without galactorrhea .
6123489	0	TRH	32,35	Prolactin	0,9	TRH	Prolactin	CHEBI:35940	5617	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Prolactin secretion response to TRH stimulation in acute and chronic schizophrenic patients under neuroleptic treatment .
6412497	0	TRH	54,57	Prolactin	0,9	TRH	Prolactin	CHEBI:35940	5617	Chemical	Gene	thyroliberin|appos|START_ENTITY responses|nmod|thyroliberin responses|compound|END_ENTITY	Prolactin and thyrotrophin responses to thyroliberin -LRB- TRH -RRB- in patients with growth_hormone deficiency : study in 167 patients .
7894262	0	TRH	31,34	Prolactin	0,9	TRH	Prolactin	CHEBI:35940	5617	Chemical	Gene	responses|ccomp|START_ENTITY responses|nsubj|END_ENTITY	Prolactin and TSH responses to TRH and to haloperidol in schizophrenic patients before and after treatment .
96645	0	TRH	31,34	Prolactin	0,9	TRH	Prolactin	CHEBI:35940	5617	Chemical	Gene	responses|nmod|START_ENTITY responses|compound|END_ENTITY	Prolactin and TSH responses to TRH , chlorpromazine and L-dopa in children with human growth_hormone_deficiency .
17873321	0	TRH	68,71	Prolactin-releasing_Peptide	0,27	TRH	Prolactin-releasing Peptide	CHEBI:35940	63850(Tax:10116)	Chemical	Gene	increases|nmod|START_ENTITY increases|nsubj|END_ENTITY	Prolactin-releasing_Peptide -LRB- PrRP -RRB- increases prolactin responses to TRH in vitro and in vivo .
805438	0	TRH	257,260	TRH	41,44	TRH	TRH	CHEBI:35940	613414(Tax:9913)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|appos|END_ENTITY	Effect of thyrotropin-releasing_hormone -LRB- TRH -RRB- on bovine plasma thyroxine levels at 18.5 and 35 C. Six mature nonlactating Holstein cows were subjected to a test procedure of a sham period -LRB- saline injection -RRB- of 10 days that prededed and followed each 14 day TRH treatment period at 18.5 and 35 degrees .
1791264	0	TRH	56,59	TSH_and_prolactin	25,42	TRH	TSH and prolactin	CHEBI:35940	5617	Chemical	Gene	responses|nmod|START_ENTITY responses|amod|END_ENTITY	Effects of ECT course on TSH_and_prolactin responses to TRH in depressed patients .
8364352	0	TRH	45,48	TSH_and_prolactin	14,31	TRH	TSH and prolactin	CHEBI:35940	5617	Chemical	Gene	Evaluation|acl|START_ENTITY Evaluation|nmod|responses responses|amod|END_ENTITY	Evaluation of TSH_and_prolactin responses to TRH as predictors of the therapeutic effect of ECT in depression .
2557225	0	TRH	76,79	beta-endorphin	31,45	TRH	beta-endorphin	CHEBI:35940	5443	Chemical	Gene	response|nmod|START_ENTITY response|nmod|END_ENTITY	Paradoxical response of plasma beta-endorphin to combined administration of TRH and GnRH in adrenal_disorders .
104407	0	TRH	79,82	growth_hormone	9,23	TRH	growth hormone	CHEBI:35940	2688	Chemical	Gene	responses|appos|START_ENTITY responses|compound|END_ENTITY	Abnormal growth_hormone responses to CB-154 and thyrotropin-releasing_hormone -LRB- TRH -RRB- in patients with acromegaly .
107053	0	TRH	137,140	growth_hormone	97,111	TRH	growth hormone	CHEBI:35940	2688	Chemical	Gene	secretion|nmod|START_ENTITY -RSB-|amod|secretion END_ENTITY|dobj|-RSB-	-LSB- Anterior pituitary function in patients with cerebrovascular_disease : with special reference to growth_hormone secretion in response to TRH administration -LRB- author 's transl -RRB- -RSB- .
113143	0	TRH	158,161	growth_hormone	132,146	TRH	growth hormone	CHEBI:35940	2688	Chemical	Gene	induced|nmod|START_ENTITY induced|dobj|release release|amod|END_ENTITY	Bromocriptine suppression of TRH-stimulated prolactin and thyrotrophin release and accompanying inhibition of bromocriptine induced growth_hormone release by TRH in normal man .
1675015	0	TRH	41,44	growth_hormone	48,62	TRH	growth hormone	CHEBI:35940	2688	Chemical	Gene	Lack|nmod|START_ENTITY Lack|nmod|secretion secretion|amod|END_ENTITY	-LSB- Lack of effect of the administration of TRH on growth_hormone secretion induced by dexamethasone -RSB- .
177804	0	TRH	60,63	growth_hormone	16,30	TRH	growth hormone	CHEBI:35940	2688	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Stimulation Stimulation|nmod|END_ENTITY	-LSB- Stimulation of growth_hormone and prolactin secretion with TRH in acromegaly -LRB- author 's transl -RRB- -RSB- .
2123920	0	TRH	50,53	growth_hormone	4,18	TRH	growth hormone	CHEBI:35940	2688	Chemical	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	The growth_hormone , prolactin_and_TSH response to TRH and L-dopa in patients with hyperprolactinaemia and a normal-sized sella turcica may denote a pituitary_adenoma .
219872	0	TRH	11,14	growth_hormone	18,32	TRH	growth hormone	CHEBI:35940	2688	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|release release|amod|END_ENTITY	-LSB- Effect of TRH on growth_hormone -LRB- GH -RRB- release induced with ACTH -RSB- .
3097114	0	TRH	23,26	growth_hormone	30,44	TRH	growth hormone	CHEBI:35940	2688	Chemical	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	Effects of intravenous TRH on growth_hormone and cortisol serum levels in children and adolescents with insulin_dependent_diabetes_mellitus .
3108068	0	TRH	124,127	growth_hormone	144,158	TRH	growth hormone	CHEBI:35940	378781(Tax:9031)	Chemical	Gene	stimulation|appos|START_ENTITY stimulation|nmod|secretion secretion|amod|END_ENTITY	Effects of insulin-like_growth_factor_I -LRB- IGF-I -RRB- on growth_hormone-releasing factor -LRB- GRF -RRB- and thyrotropin-releasing_hormone -LRB- TRH -RRB- stimulation of growth_hormone -LRB- GH -RRB- secretion in the domestic fowl -LRB- Gallus_domesticus -RRB- .
3115018	0	TRH	91,94	growth_hormone	17,31	TRH	growth hormone	CHEBI:35940	2688	Chemical	Gene	stimulated|nmod|START_ENTITY secretion|acl|stimulated END_ENTITY|xcomp|secretion	Arginine induced growth_hormone -LRB- hGH -RRB- response and paradoxical hGH secretion stimulated by TRH in diabetes_mellitus .
6150770	0	TRH	114,117	growth_hormone	84,98	TRH	growth hormone	CHEBI:35940	2688	Chemical	Gene	injection|compound|START_ENTITY associated|nmod|injection associated|nmod|increase increase|amod|END_ENTITY	Studies in constitutionally tall adolescents : somatostatin decrease associated with growth_hormone increase after TRH injection .
6412497	0	TRH	54,57	growth_hormone	76,90	TRH	growth hormone	CHEBI:35940	2688	Chemical	Gene	thyroliberin|appos|START_ENTITY thyroliberin|nmod|patients patients|nmod|deficiency deficiency|amod|END_ENTITY	Prolactin and thyrotrophin responses to thyroliberin -LRB- TRH -RRB- in patients with growth_hormone deficiency : study in 167 patients .
6432628	0	TRH	93,96	growth_hormone	15,29	TRH	growth hormone	CHEBI:35940	378781(Tax:9031)	Chemical	Gene	thyrotrophin-releasing_hormone|appos|START_ENTITY secretion|nmod|thyrotrophin-releasing_hormone secretion|nsubj|Stimulation Stimulation|nmod|END_ENTITY	Stimulation of growth_hormone secretion in dwarf chickens by thyrotrophin-releasing_hormone -LRB- TRH -RRB- or human pancreatic growth-hormone-releasing factor -LRB- hpGRF -RRB- .
6436724	0	TRH	174,177	growth_hormone	27,41	TRH	growth hormone	CHEBI:35940	378781(Tax:9031)	Chemical	Gene	factor|appos|START_ENTITY secretion|nmod|factor secretion|nsubj|stimulation stimulation|nmod|END_ENTITY	Comparative stimulation of growth_hormone secretion in anaesthetized chickens by human pancreatic growth_hormone-releasing factor -LRB- hpGRF -RRB- and thyrotrophin-releasing_hormone -LRB- TRH -RRB- .
6797811	0	TRH	14,17	growth_hormone	27,41	TRH	growth hormone	CHEBI:35940	81668(Tax:10116)	Chemical	Gene	Thyroliberin|appos|START_ENTITY induced|nsubj|Thyroliberin induced|dobj|release release|amod|END_ENTITY	Thyroliberin -LRB- TRH -RRB- induced growth_hormone -LRB- GH -RRB- release : test of maturation of hypothalamo-pituitary axis in postnatal rat .
6799379	0	TRH	14,17	growth_hormone	54,68	TRH	growth hormone	CHEBI:35940	2688	Chemical	Gene	effect|nmod|START_ENTITY cyproheptadine|nsubj|effect cyproheptadine|nmod|response response|amod|END_ENTITY	The effect of TRH , cyproheptadine and pimozide on the growth_hormone response to intramuscular glucagon .
7787317	0	TRH	0,3	growth_hormone	65,79	TRH	growth hormone	CHEBI:35940	2688	Chemical	Gene	test|compound|START_ENTITY test|nmod|END_ENTITY	TRH stimulation test in healthy elderly : paradoxical response of growth_hormone is abnormal in normal aging .
820711	0	TRH	46,49	growth_hormone	54,68	TRH	growth hormone	CHEBI:35940	2688	Chemical	Gene	thyrotropin-releasing_hormone|appos|START_ENTITY thyrotropin-releasing_hormone|nmod|release release|amod|END_ENTITY	Suppression by thyrotropin-releasing_hormone -LRB- TRH -RRB- of growth_hormone release induced by arginine and insulin-induced hypoglycemia in man .
98725	0	TRH	45,48	growth_hormone	78,92	TRH	growth hormone	CHEBI:35940	378781(Tax:9031)	Chemical	Gene	thyrotropin-releasing_hormone|appos|START_ENTITY effect|nmod|thyrotropin-releasing_hormone effect|nmod|secretion secretion|compound|END_ENTITY	The effect of thyrotropin-releasing_hormone -LRB- TRH -RRB- and somatostatin -LRB- GHRIH -RRB- on growth_hormone and prolactin secretion in vitro and in vivo in the domestic fowl -LRB- Gallus_domesticus -RRB- .
7816186	0	TRH	47,50	interleukin-2	10,23	TRH	interleukin-2	CHEBI:35940	3558	Chemical	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	Increased interleukin-2 levels during standard TRH test in man .
1000028	0	TRH	36,39	prolactin	7,16	TRH	prolactin	CHEBI:35940	5617	Chemical	Gene	START_ENTITY|nsubj|response response|compound|END_ENTITY	Plasma prolactin response to L-dopa TRH and metaclopramide in thyrotoxicosis .
113144	0	TRH	45,48	prolactin	15,24	TRH	prolactin	CHEBI:35940	5617	Chemical	Gene	serum|xcomp|START_ENTITY serum|dobj|END_ENTITY	Maternal serum prolactin and its response to TRH in normal and complicated early pregnancy .
16725998	0	TRH	44,47	prolactin	85,94	TRH	prolactin	CHEBI:35940	396965(Tax:9823)	Chemical	Gene	Effect|appos|START_ENTITY Effect|appos|removal removal|nmod|concentrations concentrations|compound|END_ENTITY	Effect of dopamine agonists or antagonists , TRH , stress and piglet removal on plasma prolactin concentrations in lactating gilts .
2118020	0	TRH	73,76	prolactin	102,111	TRH	prolactin	CHEBI:35940	396965(Tax:9823)	Chemical	Gene	hormone|appos|START_ENTITY releasing|dobj|hormone thyroid|acl|releasing Effect|nmod|thyroid Effect|nmod|END_ENTITY	Effect of dose and route of administration of thyroid releasing hormone -LRB- TRH -RRB- on the concentration of prolactin -LRB- PRL -RRB- and thyroxine -LRB- T4 -RRB- in cyclic gilts .
22354782	0	TRH	59,62	prolactin	28,37	TRH	prolactin	CHEBI:35940	24683(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|modulates modulates|dep|secretion secretion|compound|END_ENTITY	17b-Estradiol modulates the prolactin secretion induced by TRH through membrane estrogen receptors via PI3K/Akt in female rat anterior pituitary cell culture .
3003766	0	TRH	40,43	prolactin	18,27	TRH	prolactin	CHEBI:35940	5617	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Submaximal plasma prolactin response to TRH and dopamine activity in man .
3080846	0	TRH	56,59	prolactin	22,31	TRH	prolactin	CHEBI:35940	5617	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|evaluation evaluation|nmod|END_ENTITY	Dynamic evaluation of prolactin secretion by successive TRH and metoclopramide stimulations .
3108600	0	TRH	65,68	prolactin	43,52	TRH	prolactin	CHEBI:35940	24683(Tax:10116)	Chemical	Gene	effect|acl|START_ENTITY effect|nmod|naloxone naloxone|nmod|response response|compound|END_ENTITY	In vivo and in vitro effect of naloxone on prolactin response to TRH in rat .
3111873	0	TRH	26,29	prolactin	4,13	TRH	prolactin	CHEBI:35940	5617	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	The prolactin response to TRH and domperidone does not differentiate male_hypothalamic_hypogonadism and constitutional delay of puberty .
3148269	0	TRH	32,35	prolactin	10,19	TRH	prolactin	CHEBI:35940	5617	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Increased prolactin response to TRH in polycystic_ovary_syndrome with low basal prolactin values .
3148269	0	TRH	32,35	prolactin	80,89	TRH	prolactin	CHEBI:35940	5617	Chemical	Gene	response|nmod|START_ENTITY response|nmod|polycystic_ovary_syndrome polycystic_ovary_syndrome|nmod|END_ENTITY	Increased prolactin response to TRH in polycystic_ovary_syndrome with low basal prolactin values .
3149403	0	TRH	55,58	prolactin	16,25	TRH	prolactin	CHEBI:35940	5617	Chemical	Gene	thyroliberin|appos|START_ENTITY secretion|nmod|thyroliberin secretion|nsubj|Stimulation Stimulation|nmod|END_ENTITY	-LSB- Stimulation of prolactin secretion with thyroliberin -LRB- TRH -RRB- .
3921974	0	TRH	29,32	prolactin	36,45	TRH	prolactin	CHEBI:35940	24683(Tax:10116)	Chemical	Gene	action|nmod|START_ENTITY action|nmod|secretion secretion|compound|END_ENTITY	Central inhibitory action of TRH on prolactin secretion in the rat .
3930250	0	TRH	97,100	prolactin	64,73	TRH	prolactin	CHEBI:35940	5617	Chemical	Gene	suppression|nmod|START_ENTITY suppression|dep|TSH TSH|dep|END_ENTITY	Dexamethasone suppression and multiple hormonal responses -LRB- TSH , prolactin and growth_hormone -RRB- to TRH in some psychiatric_disorders .
6149021	0	TRH	11,14	prolactin	47,56	TRH	prolactin	CHEBI:35940	5617	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|releases releases|nmod|hormone hormone|compound|END_ENTITY	Effects of TRH and somatostatin on releases of prolactin and growth hormone in vitro by the pituitary of Poecilia latipinna .
6437954	0	TRH	130,133	prolactin	25,34	TRH	prolactin	CHEBI:35940	5617	Chemical	Gene	stimulating|nmod|START_ENTITY luteinizing|advcl|stimulating Effect|acl|luteinizing Effect|nmod|metergoline metergoline|nmod|END_ENTITY	Effect of metergoline on prolactin , follicle stimulating hormone , luteinizing hormone and thyroid stimulating hormone response to TRH and LHRH in normal men and women .
6778491	0	TRH	64,67	prolactin	41,50	TRH	prolactin	CHEBI:35940	5617	Chemical	Gene	-RSB-|compound|START_ENTITY effects|nmod|-RSB- effects|nmod|atropine atropine|nmod|levels levels|compound|END_ENTITY	-LSB- Inhibitory effects of atropine on serum prolactin levels after TRH stimulation -RSB- .
6779004	0	TRH	10,13	prolactin	34,43	TRH	prolactin	CHEBI:35940	5617	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of TRH on the secretion of prolactin in ewes at various stages of pregnancy and in non-pregnant ewes during the breeding season and seasonal anoestrus .
6813758	0	TRH	91,94	prolactin	60,69	TRH	prolactin	CHEBI:35940	5617	Chemical	Gene	_|nmod|START_ENTITY _|nmod|END_ENTITY	Effect of the plasma estrone/17 _ beta-estradiol ratio on the prolactin and TSH responses to TRH .
7613098	0	TRH	85,88	prolactin	46,55	TRH	prolactin	CHEBI:35940	5617	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|responses responses|compound|END_ENTITY	Effects of methysergide and ritanserin on the prolactin and thyrotropin responses to TRH in depressed patients .
7648371	0	TRH	67,70	prolactin	103,112	TRH	prolactin	CHEBI:35940	24683(Tax:10116)	Chemical	Gene	effects|compound|START_ENTITY effects|nmod|line line|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Stimulation of C-fos and jun_B proto-oncogenes : potential role of TRH effects in clone cell line with prolactin -LRB- GH3B6 -RRB- -RSB- .
825328	0	TRH	65,68	prolactin	25,34	TRH	prolactin	CHEBI:35940	5617	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|oestrogens oestrogens|nmod|responses responses|compound|END_ENTITY	Effects of oestrogens on prolactin and thyrotrophin responses to TRH in women during the menstrual cycle and under oral contraceptive treatment .
2123920	0	TRH	50,53	prolactin_and_TSH	20,37	TRH	prolactin and TSH	CHEBI:35940	5617	Chemical	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	The growth_hormone , prolactin_and_TSH response to TRH and L-dopa in patients with hyperprolactinaemia and a normal-sized sella turcica may denote a pituitary_adenoma .
402375	0	TRH	58,61	prolactin_and_TSH	27,44	TRH	prolactin and TSH	CHEBI:35940	5617	Chemical	Gene	Effect|acl|START_ENTITY Effect|nmod|dexamethasone dexamethasone|nmod|responses responses|amod|END_ENTITY	Effect of dexamethasone on prolactin_and_TSH responses to TRH and metoclopramide in man .
1506619	0	TRH	30,33	protirelin	18,28	TRH	protirelin	CHEBI:35940	7200	Chemical	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Direct effects of protirelin -LRB- TRH -RRB- on cultured porcine thyrocytes .
2129364	0	TRH	50,53	thyroglobulin	18,31	TRH	thyroglobulin	CHEBI:35940	7038	Chemical	Gene	test|compound|START_ENTITY levels|nmod|test levels|compound|END_ENTITY	-LSB- Changes in serum thyroglobulin levels during the TRH test in euthyroid female patients with diffuse_and_nodular_goiters -RSB- .
3108068	0	TRH	124,127	thyrotropin-releasing_hormone	93,122	TRH	thyrotropin-releasing hormone	CHEBI:35940	414344(Tax:9031)	Chemical	Gene	stimulation|appos|START_ENTITY stimulation|amod|END_ENTITY	Effects of insulin-like_growth_factor_I -LRB- IGF-I -RRB- on growth_hormone-releasing factor -LRB- GRF -RRB- and thyrotropin-releasing_hormone -LRB- TRH -RRB- stimulation of growth_hormone -LRB- GH -RRB- secretion in the domestic fowl -LRB- Gallus_domesticus -RRB- .
805438	0	TRH	257,260	thyrotropin-releasing_hormone	10,39	TRH	thyrotropin-releasing hormone	CHEBI:35940	613414(Tax:9913)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of thyrotropin-releasing_hormone -LRB- TRH -RRB- on bovine plasma thyroxine levels at 18.5 and 35 C. Six mature nonlactating Holstein cows were subjected to a test procedure of a sham period -LRB- saline injection -RRB- of 10 days that prededed and followed each 14 day TRH treatment period at 18.5 and 35 degrees .
20687402	0	TRH	106,109	thyrotropin_releasing_hormone	75,104	TRH	thyrotropin releasing hormone	CHEBI:35940	7200	Chemical	Gene	deficiency|appos|START_ENTITY deficiency|compound|END_ENTITY	Isolated idiopathic_central_hypothyroidism in an adult , possibly caused by thyrotropin_releasing_hormone -LRB- TRH -RRB- deficiency .
3937548	0	TRH	42,45	thyrotropin_releasing_hormone	11,40	TRH	thyrotropin releasing hormone	CHEBI:35940	22044(Tax:10090)	Chemical	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of thyrotropin_releasing_hormone -LRB- TRH -RRB- on GABA -LRB- gamma_aminobutyric_acid -RRB- metabolism in mouse and rat brains : as to the activities of GAD -LRB- glutamic_acid decarboxylase -RRB- , GABA-T -LRB- GABA-transaminase -RRB- and GABA re-uptake -RSB- .
22197203	0	TRK-380	26,33	b3-adrenoceptor	59,74	TRK-380	b3-adrenoceptor	null	155	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Pharmacological effect of TRK-380 , a novel selective human b3-adrenoceptor agonist , on mammalian detrusor strips .
24075004	0	TRK-380	0,7	b3-adrenoceptor	33,48	TRK-380	b3-adrenoceptor	null	155	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	TRK-380 , a novel selective human b3-adrenoceptor agonist , ameliorates formalin-induced pollakiuria in rats and carbachol-induced bladder_contraction in dogs .
21410690	0	TS-071	0,6	SGLT2	78,83	TS-071	SGLT2	MESH:C549343	64522(Tax:10116)	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|appos|END_ENTITY	TS-071 is a novel , potent and selective renal sodium-glucose_cotransporter_2 -LRB- SGLT2 -RRB- inhibitor with anti-hyperglycaemic activity .
21410690	0	TS-071	0,6	sodium-glucose_cotransporter_2	46,76	TS-071	sodium-glucose cotransporter 2	MESH:C549343	64522(Tax:10116)	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|compound|END_ENTITY	TS-071 is a novel , potent and selective renal sodium-glucose_cotransporter_2 -LRB- SGLT2 -RRB- inhibitor with anti-hyperglycaemic activity .
19122336	0	TSU-68	131,137	CYP1A1	40,46	TSU-68	CYP1A1	MESH:C524722	24296(Tax:10116)	Chemical	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	Time-dependent induction of rat hepatic CYP1A1 and CYP1A2 expression after single-dose administration of the anti-angiogenic agent TSU-68 .
21567184	0	TSU-68	35,41	S-1_and_oxaliplatin	126,145	TSU-68	S-1 and oxaliplatin	MESH:C524722	5707	Chemical	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	A phase I pharmacokinetic study of TSU-68 -LRB- a multiple tyrosine kinase inhibitor of VEGFR-2 , FGF and PDFG -RRB- in combination with S-1_and_oxaliplatin in metastatic colorectal_cancer patients previously treated with chemotherapy .
21567184	0	TSU-68	35,41	VEGFR-2	83,90	TSU-68	VEGFR-2	MESH:C524722	3791	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	A phase I pharmacokinetic study of TSU-68 -LRB- a multiple tyrosine kinase inhibitor of VEGFR-2 , FGF and PDFG -RRB- in combination with S-1_and_oxaliplatin in metastatic colorectal_cancer patients previously treated with chemotherapy .
11444868	0	TT-232	36,42	PKCdelta	77,85	TT-232	PKCdelta	MESH:C102210|MESH:C094462	5580	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	The antitumor somatostatin analogue TT-232 induces cell cycle arrest through PKCdelta and c-Src .
24348533	0	TU-100	21,27	Adrenomedullin	100,114	TU-100	Adrenomedullin	MESH:C559645	11535(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|Involvement Involvement|nmod|END_ENTITY	Preventive Effect of TU-100 on a Type-2 Model of Colitis in Mice : Possible Involvement of Enhancing Adrenomedullin in Intestinal Epithelial Cells .
11815739	0	TU-572	0,6	CD45	31,35	TU-572	CD45	null	19264(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	TU-572 , a potent and selective CD45 inhibitor , suppresses IgE-mediated anaphylaxis and murine contact hypersensitivity reactions .
16923170	9	TUDCA	1093,1098	p53	1029,1032	TUDCA	p53	MESH:C031655	7157	Chemical	Gene	modulated|nmod|START_ENTITY modulated|nsubjpass|activity activity|compound|END_ENTITY	p53 activity , and Bcl-2 and Bax changes , were also modulated by TUDCA .
22207755	0	TUG	59,62	ATPase	81,87	TUG	ATPase	null	1769	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	The ubiquitin regulatory X -LRB- UBX -RRB- domain-containing protein TUG regulates the p97 ATPase and resides at the endoplasmic reticulum-golgi intermediate compartment .
18528859	0	TW-37	0,5	Bcl-2	37,42	TW-37	Bcl-2	null	596	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	TW-37 , a small-molecule inhibitor of Bcl-2 , inhibits cell growth and invasion in pancreatic_cancer .
26359711	0	TY-51924	31,39	NHE	61,64	TY-51924	NHE	MESH:C000592017	285335	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Randomized controlled trial of TY-51924 , a novel hydrophilic NHE inhibitor , in acute myocardial_infarction .
19671747	0	TZD18	54,59	peroxisome_proliferator-activated_receptor_alpha	85,133	TZD18	peroxisome proliferator-activated receptor alpha	MESH:C483680	5465	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of endoplasmic_reticulum_stress response by TZD18 , a novel dual ligand for peroxisome_proliferator-activated_receptor_alpha / gamma , in human breast_cancer cells .
1909963	0	TZI-41127	11,20	5-lipoxygenase	40,54	TZI-41127	5-lipoxygenase	MESH:C063918	25290(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effects of TZI-41127 , a novel selective 5-lipoxygenase inhibitor , on A23187-induced pleurisy in rats .
17436082	0	TZP-101	53,60	ghrelin	28,35	TZP-101	ghrelin	MESH:C528884	59301(Tax:10116)	Chemical	Gene	agonist|dobj|START_ENTITY agonist|nsubj|effects effects|nmod|receptor receptor|compound|END_ENTITY	Prokinetic effects of a new ghrelin receptor agonist TZP-101 in a rat model of postoperative_ileus .
19121631	0	TZP-101	39,46	ghrelin_receptor	14,30	TZP-101	ghrelin receptor	MESH:C528884	84022(Tax:10116)	Chemical	Gene	agonist|dobj|START_ENTITY agonist|nsubj|Effect Effect|nmod|END_ENTITY	Effect of the ghrelin_receptor agonist TZP-101 on colonic transit in a rat model of postoperative_ileus .
19222910	0	TZP-201	10,17	motilin	27,34	TZP-201	motilin	null	4295	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Effect of TZP-201 , a novel motilin receptor antagonist , in the colon of the musk shrew -LRB- Suncus murinus -RRB- .
7528148	0	TZP-4238	25,33	androgen_receptor	51,68	TZP-4238	androgen receptor	MESH:C069297	24208(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of antiandrogen TZP-4238 on the prostatic androgen_receptor and prostatic androgen in rat -RSB- .
11464105	0	Tacalcitol	0,10	nerve_growth_factor	42,61	Tacalcitol	nerve growth factor	MESH:C023850	4803	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|compound|END_ENTITY	Tacalcitol , an active vitamin_D3 , induces nerve_growth_factor production in human epidermal keratinocytes .
2470856	0	Tachykinin	0,10	NK1	28,31	Tachykinin	NK1	MESH:D015320	21333(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|nmod|type type|compound|END_ENTITY	Tachykinin receptors of the NK1 type -LRB- substance_P -RRB- coupled positively to phospholipase C on cortical astrocytes from the newborn mouse in primary culture .
9543242	0	Tachykinin	0,10	NK2	11,14	Tachykinin	NK2	MESH:D015320	6863	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Tachykinin NK2 receptors predominantly mediate tachykinin-induced contractions in ovine trachea .
15501700	0	Tachykinin	0,10	NK3-receptor	11,23	Tachykinin	NK3-receptor	MESH:D015320	21338(Tax:10090)	Chemical	Gene	deficiency|compound|START_ENTITY deficiency|compound|END_ENTITY	Tachykinin NK3-receptor deficiency does not inhibit pulmonary_eosinophilia in allergic mice .
7533632	0	Tachykinin	0,10	NK3_receptor	11,23	Tachykinin	NK3 receptor	MESH:D015320	24808(Tax:10116)	Chemical	Gene	agonist|compound|START_ENTITY agonist|compound|END_ENTITY	Tachykinin NK3_receptor agonist blocks sodium deficiency-induced shift in taste reactivity .
19154444	0	Tachykinin	0,10	cyclooxygenase-2	34,50	Tachykinin	cyclooxygenase-2	MESH:D015320	5743	Chemical	Gene	modulation|compound|START_ENTITY modulation|nmod|expression expression|amod|END_ENTITY	Tachykinin receptor modulation of cyclooxygenase-2 expression in human polymorphonuclear leucocytes .
12732347	0	Tachykinin	0,10	neurokinin_1	61,73	Tachykinin	neurokinin 1	MESH:D015320	6863	Chemical	Gene	peptide-induced|nsubj|START_ENTITY peptide-induced|dobj|activation activation|nmod|receptors receptors|amod|END_ENTITY	Tachykinin peptide-induced activation and desensitization of neurokinin_1 receptors .
3481842	0	Tachykinin	0,10	neurokinin_B	68,80	Tachykinin	neurokinin B	MESH:D015320	29191(Tax:10116)	Chemical	Gene	antagonist|nsubj|START_ENTITY antagonist|dep|antagonists antagonists|compound|END_ENTITY	Tachykinin antagonist I : Specific , competitive and tissue-selective neurokinin_B antagonists on contractile activity in smooth muscles .
2470856	0	Tachykinin	0,10	substance_P	38,49	Tachykinin	substance P	MESH:D015320	21333(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Tachykinin receptors of the NK1 type -LRB- substance_P -RRB- coupled positively to phospholipase C on cortical astrocytes from the newborn mouse in primary culture .
9022979	0	Tachykinin	0,10	substance_P	62,73	Tachykinin	substance P	MESH:D015320	6863	Chemical	Gene	NK-1_receptor|compound|START_ENTITY probed|nsubj|NK-1_receptor probed|nmod|analogues analogues|nmod|END_ENTITY	Tachykinin NK-1_receptor probed with constrained analogues of substance_P .
9243258	0	Tachykinin	0,10	substance_P	52,63	Tachykinin	substance P	MESH:D015320	6863	Chemical	Gene	neurokinin_A|compound|START_ENTITY neurokinin_A|dep|END_ENTITY	Tachykinin antagonist FK224 inhibits neurokinin_A - , substance_P - and capsaicin-induced human bronchial contraction .
10817586	0	Tacrine	0,7	acetylcholinesterase	22,42	Tacrine	acetylcholinesterase	MESH:D013619	83817(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Tacrine , a reversible acetylcholinesterase inhibitor , induces myopathy .
2761772	0	Tacrine	0,7	acetylcholinesterase	52,72	Tacrine	acetylcholinesterase	MESH:D013619	83817(Tax:10116)	Chemical	Gene	slows|nsubj|START_ENTITY slows|dobj|rate rate|acl|ageing ageing|nmod|END_ENTITY	Tacrine slows the rate of ageing of sarin-inhibited acetylcholinesterase .
2913485	0	Tacrine	0,7	acetylcholinesterase	22,42	Tacrine	acetylcholinesterase	MESH:D013619	43	Chemical	Gene	protection|amod|START_ENTITY protection|nmod|END_ENTITY	Tacrine protection of acetylcholinesterase from inactivation by diisopropylfluorophosphate : a circular dichroism study .
16628701	0	Tacrolimus	0,10	ABCB1	63,68	Tacrolimus	ABCB1	MESH:D016559	5243	Chemical	Gene	requirement|amod|START_ENTITY requirement|nmod|END_ENTITY	Tacrolimus dose requirement in relation to donor and recipient ABCB1 and CYP3A5 gene polymorphisms in Chinese liver transplant patients .
26352670	0	Tacrolimus	43,53	Angiopoietin-Like-4	0,19	Tacrolimus	Angiopoietin-Like-4	MESH:D016559	51129	Chemical	Gene	Target|nmod|START_ENTITY END_ENTITY|appos|Target	Angiopoietin-Like-4 , a Potential Target of Tacrolimus , Predicts Earlier Podocyte Injury in Minimal_Change_Disease .
22895606	0	Tacrolimus	0,10	CCL2	44,48	Tacrolimus	CCL2	MESH:D016559	6347	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	Tacrolimus -LRB- FK506 -RRB- suppresses TNF-a-induced CCL2 -LRB- MCP-1 -RRB- and CXCL10 -LRB- IP-10 -RRB- expression via the inhibition of p38 MAP kinase activation in human colonic myofibroblasts .
12694072	0	Tacrolimus	0,10	CYP3A5	71,77	Tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	related|nsubjpass|START_ENTITY related|nmod|polymorphisms polymorphisms|compound|END_ENTITY	Tacrolimus dosing in pediatric heart transplant patients is related to CYP3A5 and MDR1 gene polymorphisms .
15729180	0	Tacrolimus	0,10	CYP3A5	33,39	Tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	pharmacogenetics|nsubj|START_ENTITY pharmacogenetics|parataxis|predicts predicts|dep|END_ENTITY	Tacrolimus pharmacogenetics : the CYP3A5 * 1 allele predicts low dose-normalized tacrolimus blood concentrations in whites and South Asians .
20970601	8	Tacrolimus	1392,1402	CYP3A5	1458,1464	Tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	ratios|amod|START_ENTITY ratios|nmod|patients patients|nmod|END_ENTITY	Tacrolimus concentration/dose ratios in heterozygote patients for CYP3A5 * 3 genotypes was > 120 % lower than for the homozygote CYP3A5 * 3 genotype -LRB- 0.65 0.04 vs 1.45 0.05 ; P < .0001 -RRB- .
21677300	0	Tacrolimus	65,75	CYP3A5	0,6	Tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	requirements|compound|START_ENTITY impact|nmod|requirements polymorphisms|dep|impact polymorphisms|compound|END_ENTITY	CYP3A5 and ABCB1 polymorphisms in donor and recipient : impact on Tacrolimus dose requirements and clinical outcome after renal transplantation .
21844990	0	Tacrolimus	0,10	CYP3A5	99,105	Tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	START_ENTITY|dep|study study|nmod|non-expressors non-expressors|nummod|END_ENTITY	Tacrolimus and 3-hydroxy-3-methylglutaryl-coenzyme_A reductase inhibitors : An interaction study in CYP3A5 non-expressors , renal transplant recipients .
23438946	9	Tacrolimus	1253,1263	CYP3A5	1318,1324	Tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	reduced|nsubj|START_ENTITY reduced|nmod|expressers expressers|compound|END_ENTITY	Tacrolimus slightly reduced the AUC - of amlodipine in both CYP3A5 expressers and non-expressers .
23837476	0	Tacrolimus	0,10	CYP3A5	77,83	Tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	requirement|amod|START_ENTITY requirement|dep|influence influence|nmod|polymorphism polymorphism|compound|END_ENTITY	Tacrolimus dose requirement in pediatric liver transplantation : influence of CYP3A5 gene polymorphism .
25310192	0	Tacrolimus	13,23	CYP3A5	44,50	Tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	Requirement|compound|START_ENTITY Requirement|nmod|END_ENTITY	Personalized Tacrolimus Dose Requirement by CYP3A5 but Not ABCB1 or ACE Genotyping in Both Recipient and Donor after Pediatric Liver Transplantation .
25565672	0	Tacrolimus	98,108	CYP3A5	34,40	Tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	Concentration|compound|START_ENTITY Effect|nmod|Concentration Effect|nmod|Polymorphism Polymorphism|nmod|END_ENTITY	Effect of Genetic Polymorphism of CYP3A5 and CYP2C19 and Concomitant Use of Voriconazole on Blood Tacrolimus Concentration in Patients Receiving Hematopoietic Stem Cell Transplantation .
25869250	0	Tacrolimus	91,101	CYP3A5	11,17	Tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY polymorphism|nmod|pharmacokinetics polymorphism|nsubj|Effects Effects|nmod|genotypes genotypes|nummod|END_ENTITY	Effects of CYP3A5 genotypes , ABCB1 C3435T and G2677T/A polymorphism on pharmacokinetics of Tacrolimus in Chinese adult liver transplant patients .
25894154	0	Tacrolimus	50,60	CYP3A5	20,26	Tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	Level|compound|START_ENTITY Polymorphism|nmod|Level Polymorphism|nmod|Gene Gene|compound|END_ENTITY	Polymorphism of the CYP3A5 Gene and Its Effect on Tacrolimus Blood Level .
26450467	0	Tacrolimus	58,68	CYP3A5	24,30	Tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	Pharmacokinetics|compound|START_ENTITY Effect|nmod|Pharmacokinetics Effect|nmod|Polymorphisms Polymorphisms|compound|END_ENTITY	Combinational Effect of CYP3A5 and MDR-1 Polymorphisms on Tacrolimus Pharmacokinetics in Liver Transplant Patients .
26485092	0	Tacrolimus	32,42	CYP3A5	127,133	Tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	Concentrations|compound|START_ENTITY Study|nmod|Concentrations Study|nmod|Alleles Alleles|compound|END_ENTITY	Genomewide Association Study of Tacrolimus Concentrations in African American Kidney Transplant Recipients Identifies Multiple CYP3A5 Alleles .
26915847	0	Tacrolimus	66,76	CYP3A5	11,17	Tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|Polymorphism Polymorphism|compound|END_ENTITY	Effects of CYP3A5 Genetic Polymorphism on the Pharmacokinetics of Tacrolimus in Renal Transplant Recipients .
26518936	0	Tacrolimus	89,99	Cyp3a5	50,56	Tacrolimus	Cyp3a5	MESH:D016559	1577	Chemical	Gene	Doses|nmod|START_ENTITY Need|xcomp|Doses Need|nsubj|Carriers Carriers|nmod|END_ENTITY	Liver Transplant Patient Carriers of Polymorphism Cyp3a5 * 1 Donors May Need More Doses of Tacrolimus From the First Month After Transplantation .
19177155	0	Tacrolimus	0,10	FKBP	64,68	Tacrolimus	FKBP	MESH:D016559	14225(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|nmod|END_ENTITY	Tacrolimus reduces nitric_oxide synthase function by binding to FKBP rather than by its calcineurin effect .
9878202	0	Tacrolimus	0,10	GAP-43	52,58	Tacrolimus	GAP-43	MESH:D016559	29423(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Tacrolimus -LRB- FK506 -RRB- increases neuronal expression of GAP-43 and improves functional recovery after spinal_cord_injury in rats .
11455576	0	Tacrolimus	0,10	ICAM-1	74,80	Tacrolimus	ICAM-1	MESH:D016559	15894(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Tacrolimus , but not cyclosporine_A , significantly increases expression of ICAM-1 and IFN-gamma in the NOD mouse .
22264780	0	Tacrolimus	121,131	KCNJ11	29,35	Tacrolimus	KCNJ11	MESH:D016559	3767	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|Association Association|nmod|polymorphism polymorphism|compound|END_ENTITY	Association between a common KCNJ11 polymorphism -LRB- rs5219 -RRB- and new-onset posttransplant diabetes in patients treated with Tacrolimus .
17112846	0	Tacrolimus	0,10	MDR1	69,73	Tacrolimus	MDR1	MESH:D016559	5243	Chemical	Gene	related|nsubjpass|START_ENTITY related|nmod|polymorphisms polymorphisms|compound|END_ENTITY	Tacrolimus dosing in Chinese renal transplant patients is related to MDR1 gene C3435T polymorphisms .
24816588	0	Tacrolimus	0,10	Nox4	21,25	Tacrolimus	Nox4	MESH:D016559	50507	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Tacrolimus increases Nox4 expression in human renal fibroblasts and induces fibrosis-related genes by aberrant TGF-beta receptor signalling .
11920757	0	Tacrolimus	0,10	P-glycoprotein	78,92	Tacrolimus	P-glycoprotein	MESH:D016559	287115(Tax:10116)	Chemical	Gene	drug|nsubj|START_ENTITY drug|dep|effect effect|nmod|efflux efflux|amod|END_ENTITY	Tacrolimus is a class II low-solubility high-permeability drug : the effect of P-glycoprotein efflux on regional permeability of tacrolimus in rats .
20080907	0	Tacrolimus	0,10	P-glycoprotein	86,100	Tacrolimus	P-glycoprotein	MESH:D016559	5243	Chemical	Gene	overcomes|nsubj|START_ENTITY overcomes|ccomp|mediated mediated|nmod|END_ENTITY	Tacrolimus , a calcineurin_inhibitor , overcomes treatment unresponsiveness mediated by P-glycoprotein on lymphocytes in refractory_rheumatoid_arthritis .
25464008	0	Tacrolimus	0,10	TREM-1	30,36	Tacrolimus	TREM-1	MESH:D016559	58217(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Tacrolimus -LRB- FK506 -RRB- suppresses TREM-1 expression at an early but not at a late stage in a murine model of fungal_keratitis .
19148552	0	Tacrolimus	0,10	VEGF	57,61	Tacrolimus	VEGF	MESH:D016559	22339(Tax:10090)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|ccomp|release release|nsubj|END_ENTITY	Tacrolimus but not cyclosporine_A enhances FGF-2-induced VEGF release in osteoblasts .
25644968	0	Tacrolimus	0,10	insulin	66,73	Tacrolimus	insulin	MESH:D016559	3630	Chemical	Gene	decreases_insulin_sensitivity|nsubj|START_ENTITY decreases_insulin_sensitivity|advcl|reducing reducing|dobj|concentration concentration|compound|END_ENTITY	Tacrolimus decreases_insulin_sensitivity without reducing fasting insulin concentration : a 2-year follow-up study in kidney transplant recipients .
10071036	0	Tacrolimus	0,10	transforming_growth_factor-beta1	43,75	Tacrolimus	transforming growth factor-beta1	MESH:D016559	7040	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Tacrolimus induces increased expression of transforming_growth_factor-beta1 in mammalian lymphoid as well as nonlymphoid cells .
12923450	0	Tacrolimus	0,10	transforming_growth_factor-beta1	20,52	Tacrolimus	transforming growth factor-beta1	MESH:D016559	21803(Tax:10090)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Tacrolimus enhances transforming_growth_factor-beta1 expression and promotes tumor progression .
21437550	0	Tacrolimus	0,10	vitiligo	45,53	Tacrolimus	vitiligo	MESH:D016559	246319	Chemical	Gene	START_ENTITY|nmod|treatment treatment|nmod|END_ENTITY	Tacrolimus 0,1 % ointment in the treatment of vitiligo : a series of cases .
21499570	0	Tadalafil	53,62	Phosphodiesterase-5	78,97	Tadalafil	Phosphodiesterase-5	MESH:C429886	8654	Chemical	Gene	Cardiotoxicity|nmod|START_ENTITY Attenuation|nmod|Cardiotoxicity Attenuation|dep|Acting Acting|dep|Inhibitor Inhibitor|compound|END_ENTITY	Attenuation of Doxorubicin-induced Cardiotoxicity by Tadalafil : A Long Acting Phosphodiesterase-5 Inhibitor .
21762988	0	Tadalafil	0,9	phosphodiesterase-5	25,44	Tadalafil	phosphodiesterase-5	MESH:C429886	8654	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Tadalafil : a long-acting phosphodiesterase-5 inhibitor for the treatment of pulmonary_arterial_hypertension .
10417984	0	Tagetone	0,8	GABAA_receptor	75,89	Tagetone	GABAA receptor	MESH:C121716	396173(Tax:9031)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	Tagetone modulates the coupling of flunitrazepam and GABA binding sites at GABAA_receptor from chick brain membranes .
21872219	0	Taltirelin	0,10	thyrotropin-releasing_hormone	14,43	Taltirelin	thyrotropin-releasing hormone	null	22044(Tax:10090)	Chemical	Gene	START_ENTITY|appos|analog analog|amod|END_ENTITY	Taltirelin , a thyrotropin-releasing_hormone analog , alleviates mechanical allodynia through activation of descending monoaminergic neurons in persistent inflammatory_pain .
2884303	0	Tamoxifen	0,9	5-lipoxygenase	19,33	Tamoxifen	5-lipoxygenase	MESH:D013629	240	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Tamoxifen inhibits 5-lipoxygenase in human polymorphonuclear leucocytes .
20376192	0	Tamoxifen	0,9	ATPase	49,55	Tamoxifen	ATPase	MESH:D013629	1769	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|compound|END_ENTITY	Tamoxifen enhances the Hsp90 molecular chaperone ATPase activity .
17716978	0	Tamoxifen	0,9	CCAAT_enhancer-binding_protein_alpha	23,59	Tamoxifen	CCAAT enhancer-binding protein alpha	MESH:D013629	1050	Chemical	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	Tamoxifen induction of CCAAT_enhancer-binding_protein_alpha is required for tamoxifen-induced apoptosis .
25865311	0	Tamoxifen	0,9	CDK5	19,23	Tamoxifen	CDK5	MESH:D013629	1020	Chemical	Gene	Activity|compound|START_ENTITY Activity|compound|END_ENTITY	Tamoxifen Inhibits CDK5 Kinase Activity by Interacting with p35/p25 and Modulates the Pattern of Tau Phosphorylation .
26182810	0	Tamoxifen	0,9	CYP2D6	21,27	Tamoxifen	CYP2D6	MESH:D013629	1565	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|compound|END_ENTITY	Tamoxifen and Potent CYP2D6 Inhibitors : A Potentially Lethal Interaction .
26096876	0	Tamoxifen	0,9	ERK1/2	102,108	Tamoxifen	ERK1/2	MESH:D013629	5595;5594	Chemical	Gene	Activation|compound|START_ENTITY Activation|nmod|END_ENTITY	Tamoxifen Inhibits TGF-b-Mediated Activation of Myofibroblasts by Blocking Non-Smad Signaling Through ERK1/2 .
25643697	0	Tamoxifen	65,74	ERa	30,33	Tamoxifen	ERa	MESH:D013629	2099	Chemical	Gene	Resistance|compound|START_ENTITY Resistance|compound|END_ENTITY	Reprogramming of the ERRa and ERa Target Gene Landscape Triggers Tamoxifen Resistance in Breast_Cancer .
23805908	0	Tamoxifen	0,9	FABP4	30,35	Tamoxifen	FABP4	MESH:D013629	11770(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Tamoxifen inhibits macrophage FABP4 expression through the combined effects of the GR and PPARy pathways .
18227529	0	Tamoxifen	173,182	HER-2	126,131	Tamoxifen	HER-2	MESH:D013629	2064	Chemical	Gene	Alone|dep|START_ENTITY status|dep|Alone Relationship|nmod|status Relationship|appos|END_ENTITY	Relationship between quantitative estrogen and progesterone_receptor expression and human epidermal_growth_factor_receptor_2 -LRB- HER-2 -RRB- status with recurrence in the Arimidex , Tamoxifen , Alone or in Combination trial .
20376192	0	Tamoxifen	0,9	Hsp90	23,28	Tamoxifen	Hsp90	MESH:D013629	3320	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|amod|END_ENTITY	Tamoxifen enhances the Hsp90 molecular chaperone ATPase activity .
24615767	0	Tamoxifen	0,9	MxA	24,27	Tamoxifen	MxA	MESH:D013629	4599	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|compound|END_ENTITY	Tamoxifen downregulates MxA expression by suppressing TLR7 expression in PBMCs of males infected with HCV .
18996114	0	Tamoxifen	0,9	TGF-beta1	34,43	Tamoxifen	TGF-beta1	MESH:D013629	21803(Tax:10090)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|END_ENTITY	Tamoxifen decreases extracellular TGF-beta1 secreted from breast_cancer cells -- a post-translational regulation involving matrix metalloproteinase activity .
26176234	0	Tamoxifen	78,87	UGT1A4	39,45	Tamoxifen	UGT1A4	MESH:D013629	54657	Chemical	Gene	Metabolism|compound|START_ENTITY Impacts|nmod|Metabolism Impacts|nmod|END_ENTITY	Impacts of the Glucuronidase Genotypes UGT1A4 , UGT2B7 , UGT2B15 and UGT2B17 on Tamoxifen Metabolism in Breast Cancer Patients .
26495850	0	Tamoxifen	90,99	UGT1A4	51,57	Tamoxifen	UGT1A4	MESH:D013629	54657	Chemical	Gene	Metabolism|compound|START_ENTITY END_ENTITY|nmod|Metabolism	Correction : Impacts of the Glucuronidase Genotypes UGT1A4 , UGT2B7 , UGT2B15 and UGT2B17 on Tamoxifen Metabolism in Breast Cancer Patients .
1350452	0	Tamoxifen	0,9	c-erbB-2	23,31	Tamoxifen	c-erbB-2	MESH:D013629	2064	Chemical	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|amod|END_ENTITY	Tamoxifen up-regulates c-erbB-2 expression in oestrogen-responsive breast_cancer cells in vitro .
15696052	0	Tamoxifen	0,9	catalase	23,31	Tamoxifen	catalase	MESH:D013629	24248(Tax:10116)	Chemical	Gene	up-regulates|compound|START_ENTITY END_ENTITY|nsubj|up-regulates	Tamoxifen up-regulates catalase production , inhibits vessel wall neutrophil infiltration , and attenuates development of experimental abdominal_aortic_aneurysms .
12106699	0	Tamoxifen	0,9	choline_acetyltransferase	19,44	Tamoxifen	choline acetyltransferase	MESH:D013629	290567(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Tamoxifen enhances choline_acetyltransferase mRNA expression in rat basal forebrain cholinergic neurons .
15613455	0	Tamoxifen	0,9	clusterin	38,47	Tamoxifen	clusterin	MESH:D013629	24854(Tax:10116)	Chemical	Gene	exerts|nsubj|START_ENTITY exerts|nmod|END_ENTITY	Tamoxifen exerts agonistic effects on clusterin and complement C3 gene expression in RUCA-I primary xenografts and metastases but not normal uterus .
21242678	0	Tamoxifen	0,9	connective_tissue_growth_factor	24,55	Tamoxifen	connective tissue growth factor	MESH:D013629	1490	Chemical	Gene	downregulates|compound|START_ENTITY END_ENTITY|nsubj|downregulates	Tamoxifen downregulates connective_tissue_growth_factor to ameliorate peritoneal fibrosis .
20309015	0	Tamoxifen	96,105	cytochrome_P450_2D6	31,50	Tamoxifen	cytochrome P450 2D6	MESH:D013629	1565	Chemical	Gene	Trial|compound|START_ENTITY genotype|nmod|Trial genotype|nsubj|Efficacy Efficacy|nmod|tamoxifen tamoxifen|acl|based based|nmod|END_ENTITY	Efficacy of tamoxifen based on cytochrome_P450_2D6 , CYP2C19 and SULT1A1 genotype in the Italian Tamoxifen Prevention Trial .
10200279	0	Tamoxifen	0,9	estrogen_receptor	61,78	Tamoxifen	estrogen receptor	MESH:D013629	2099	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|cells cells|nmod|END_ENTITY	Tamoxifen inhibits acidification in cells independent of the estrogen_receptor .
14645110	0	Tamoxifen	0,9	estrogen_receptor	166,183	Tamoxifen	estrogen receptor	MESH:D013629	2099	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|expression expression|nmod|END_ENTITY	Tamoxifen inhibits cell proliferation via mitogen-activated protein kinase cascades in human ovarian_cancer cell lines in a manner not dependent on the expression of estrogen_receptor or the sensitivity to cisplatin .
18245484	0	Tamoxifen	0,9	estrogen_receptor	111,128	Tamoxifen	estrogen receptor	MESH:D013629	2099	Chemical	Gene	resistance|compound|START_ENTITY driven|nsubjpass|resistance driven|nmod|receptor receptor|acl|signaling signaling|nmod|repression repression|nmod|function function|compound|END_ENTITY	Tamoxifen resistance in breast_tumors is driven by growth factor receptor signaling with repression of classic estrogen_receptor genomic function .
24721327	0	Tamoxifen	0,9	estrogen_receptor	74,91	Tamoxifen	estrogen receptor	MESH:D013629	2099	Chemical	Gene	guided|compound|START_ENTITY liposomes|nsubj|guided liposomes|nmod|targeting targeting|advcl|END_ENTITY	Tamoxifen guided liposomes for targeting encapsulated anticancer agent to estrogen_receptor positive breast_cancer cells : in vitro and in vivo evaluation .
7053859	0	Tamoxifen	0,9	estrogen_receptor	72,89	Tamoxifen	estrogen receptor	MESH:D013629	2099	Chemical	Gene	START_ENTITY|dep|correlation correlation|nmod|growth growth|amod|binding binding|nmod|END_ENTITY	Tamoxifen and metabolites in MCF7 cells : correlation between binding to estrogen_receptor and inhibition of cell growth .
8750171	0	Tamoxifen	0,9	estrogen_receptor	51,68	Tamoxifen	estrogen receptor	MESH:D013629	2099	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|mechanism mechanism|amod|END_ENTITY	Tamoxifen inhibits hepatoma cell growth through an estrogen_receptor independent mechanism .
1350760	0	Tamoxifen	0,9	growth_hormone	31,45	Tamoxifen	growth hormone	MESH:D013629	81668(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|secretion secretion|compound|END_ENTITY	Tamoxifen attenuates pulsatile growth_hormone secretion : mediation in part by somatostatin .
1421427	0	Tamoxifen	0,9	insulin-like_growth_factor_I	24,52	Tamoxifen	insulin-like growth factor I	MESH:D013629	3479	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	Tamoxifen reduces serum insulin-like_growth_factor_I -LRB- IGF-I -RRB- .
15145521	0	Tamoxifen	0,9	maspin	36,42	Tamoxifen	maspin	MESH:D013629	5268	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Tamoxifen induces the expression of maspin through estrogen receptor-alpha .
12845228	0	Tamoxifen	0,9	progesterone_receptor	92,113	Tamoxifen	progesterone receptor	MESH:D013629	25154(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|expression expression|compound|END_ENTITY	Tamoxifen induces gonadotropin-releasing_hormone self-priming through an estrogen-dependent progesterone_receptor expression in the gonadotrope of the rat .
24568775	0	Tamoxifen	0,9	protein_C	42,51	Tamoxifen	protein C	MESH:D013629	5624	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Tamoxifen induces resistance to activated protein_C .
17526937	0	Tamoxifen	0,9	steroid_and_xenobiotic_receptor	50,81	Tamoxifen	steroid and xenobiotic receptor	MESH:D013629	8856	Chemical	Gene	activates|nsubj|START_ENTITY activates|nmod|END_ENTITY	Tamoxifen activates CYP3A4 and MDR1 genes through steroid_and_xenobiotic_receptor in breast_cancer cells .
12032853	0	Tamoxifen	0,9	telomerase_reverse_transcriptase	26,58	Tamoxifen	telomerase reverse transcriptase	MESH:D013629	7015	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Tamoxifen regulates human telomerase_reverse_transcriptase -LRB- hTERT -RRB- gene expression differently in breast and endometrial_cancer cells .
11374863	0	Tamoxifen	0,9	thrombospondin-1	62,78	Tamoxifen	thrombospondin-1	MESH:D013629	7057	Chemical	Gene	effects|compound|START_ENTITY effects|dep|role role|nmod|END_ENTITY	Tamoxifen and estrogen effects on TGF-beta formation : role of thrombospondin-1 , alphavbeta3 , and integrin-associated_protein .
24447935	0	Tamoxifen	0,9	thymidine_phosphorylase	87,110	Tamoxifen	thymidine phosphorylase	MESH:D013629	1890	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|expression expression|compound|END_ENTITY	Tamoxifen enhances erlotinib-induced cytotoxicity through down-regulating AKT-mediated thymidine_phosphorylase expression in human non-small-cell_lung_cancer cells .
19246968	0	Tamoxifen	0,9	transforming_growth_factor-alpha	19,51	Tamoxifen	transforming growth factor-alpha	MESH:D013629	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Tamoxifen inhibits transforming_growth_factor-alpha gene expression in human breast_carcinoma samples treated with triiodothyronine .
14695189	0	Tamoxifen	0,9	vascular_endothelial_growth_factor	32,66	Tamoxifen	vascular endothelial growth factor	MESH:D013629	7422	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|nmod|END_ENTITY	Tamoxifen inhibits secretion of vascular_endothelial_growth_factor in breast_cancer in vivo .
18483373	0	Tamoxifen	0,9	vascular_endothelial_growth_factor	57,91	Tamoxifen	vascular endothelial growth factor	MESH:D013629	7422	Chemical	Gene	inhibitors|compound|START_ENTITY affect|nsubj|inhibitors affect|dobj|levels levels|compound|END_ENTITY	Tamoxifen and aromatase inhibitors differentially affect vascular_endothelial_growth_factor and endostatin levels in women with breast_cancer .
8647140	0	Tamsulosin	0,10	alpha_1A-adrenoceptor	41,62	Tamsulosin	alpha 1A-adrenoceptor	MESH:C088482	148	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Tamsulosin , the first prostate-selective alpha_1A-adrenoceptor antagonist .
8647141	0	Tamsulosin	0,10	alpha_1A-adrenoceptor	41,62	Tamsulosin	alpha 1A-adrenoceptor	MESH:C088482	148	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Tamsulosin , the first prostate-selective alpha_1A-adrenoceptor antagonist .
16884702	0	Tandospirone	0,12	5-HT1A	16,22	Tandospirone	5-HT1A	MESH:C055267	24473(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Tandospirone , a 5-HT1A agonist , ameliorates movement_disorder via non-dopaminergic systems in rats with unilateral 6-hydroxydopamine-generated lesions .
23497393	0	Tandospirone	0,12	5-HT1A	16,22	Tandospirone	5-HT1A	MESH:C055267	3350	Chemical	Gene	effective|advmod|START_ENTITY effective|nsubj|agonist agonist|amod|END_ENTITY	Tandospirone , a 5-HT1A partial agonist is effective in treating anorexia_nervosa : a case series .
25232308	0	Tandospirone	0,12	5-HT1A	16,22	Tandospirone	5-HT1A	MESH:C055267	24473(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Tandospirone , a 5-HT1A partial agonist , ameliorates aberrant lactate production in the prefrontal cortex of rats exposed to blockade of N-methy-D-aspartate receptors ; Toward the therapeutics of cognitive_impairment of schizophrenia .
8113999	0	Tandospirone	0,12	prolactin	24,33	Tandospirone	prolactin	MESH:C055267	24683(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|compound|END_ENTITY	Tandospirone stimulates prolactin secretion in the rat by an action at serotonin-1A receptors .
18175263	0	Tandutinib	0,10	FLT3	49,53	Tandutinib	FLT3	MESH:C464670	2322	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Tandutinib , an oral , small-molecule inhibitor of FLT3 for the treatment of AML and other cancer indications .
12376477	0	Tangeretin	0,10	cyclin-dependent_kinases_2	59,85	Tangeretin	cyclin-dependent kinases 2	MESH:C059006	1017	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|inhibiting inhibiting|dobj|END_ENTITY	Tangeretin induces cell-cycle G1 arrest through inhibiting cyclin-dependent_kinases_2 and 4 activities as well as elevating Cdk inhibitors p21 and p27 in human colorectal_carcinoma cells .
15916751	0	Tangutorine	0,11	p21	20,23	Tangutorine	p21	MESH:C485396	1026	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Tangutorine induces p21 expression and abnormal mitosis in human colon_cancer HT-29 cells .
22322600	0	Tannic_acid	0,11	angiotensin_type_1_receptor	31,58	Tannic acid	angiotensin type 1 receptor	null	24180(Tax:10116)	Chemical	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|END_ENTITY	Tannic_acid down-regulates the angiotensin_type_1_receptor through a MAPK-dependent mechanism .
18435486	0	Tannin_1-alpha-O-galloylpunicalagin	0,35	endothelial_nitric-oxide_synthase	80,113	Tannin 1-alpha-O-galloylpunicalagin	endothelial nitric-oxide synthase	MESH:C534358	4846	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|nmod|END_ENTITY	Tannin_1-alpha-O-galloylpunicalagin induces the calcium-dependent activation of endothelial_nitric-oxide_synthase via the phosphatidylinositol 3-kinase/Akt pathway in endothelial cells .
17616290	0	Tanshinlactone_A	0,16	interleukin-2	52,65	Tanshinlactone A	interleukin-2	MESH:C525188	3558	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|compound|END_ENTITY	Tanshinlactone_A from Salvia miltiorrhiza modulates interleukin-2 and interferon-gamma gene expression .
21899995	0	Tanshinone_I	0,12	CYP1A2	23,29	Tanshinone I	CYP1A2	MESH:C021751	24297(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Tanshinone_I increases CYP1A2 protein expression and enzyme activity in primary rat hepatocytes .
26537816	0	Tanshinone_I	27,39	Nrf2	152,156	Tanshinone I	Nrf2	MESH:C021751	18024(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|dep|END_ENTITY	Neuroprotective Effects of Tanshinone_I Against 6-OHDA-Induced Oxidative Stress in Cellular and Mouse Model of Parkinson 's _ Disease Through Upregulating Nrf2 .
25615593	0	Tanshinone_I	0,12	cyclin_D1	21,30	Tanshinone I	cyclin D1	MESH:C021751	595	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|degradation degradation|amod|END_ENTITY	Tanshinone_I induces cyclin_D1 proteasomal degradation in an ERK1/2 dependent way in human colorectal_cancer cells .
18698495	0	Tanshinone_IIA	0,14	Bax	68,71	Tanshinone IIA	Bax	MESH:C021751	581	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Tanshinone_IIA inhibits human breast_cancer cells through increased Bax to Bcl-xL ratios .
22002472	0	Tanshinone_IIA	0,14	Bax	84,87	Tanshinone IIA	Bax	MESH:C021751	581	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Tanshinone_IIA inhibits human hepatocellular_carcinoma J5 cell growth by increasing Bax and caspase_3 and decreasing CD31 expression in vivo .
22890296	0	Tanshinone_IIA	0,14	ERK1/2	56,62	Tanshinone IIA	ERK1/2	MESH:C021751	50689;116590	Chemical	Gene	improves|nsubj|START_ENTITY improves|nmod|END_ENTITY	Tanshinone_IIA improves miR-133 expression through MAPK ERK1/2 pathway in hypoxic_cardiac_myocytes .
25038434	0	Tanshinone_IIA	0,14	Erk-2	96,101	Tanshinone IIA	Erk-2	MESH:C021751	116590(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	Tanshinone_IIA , a major component of Salvia milthorriza Bunge , inhibits platelet activation via Erk-2 signaling pathway .
23085565	0	Tanshinone_IIA	0,14	GATA-6	100,106	Tanshinone IIA	GATA-6	MESH:C021751	2627	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|regulation regulation|nmod|END_ENTITY	Tanshinone_IIA inhibits TNF-a-mediated induction of VCAM-1 but not ICAM-1 through the regulation of GATA-6 and IRF-1 .
26164608	0	Tanshinone_IIA	24,38	GFAP	136,140	Tanshinone IIA	GFAP	MESH:C021751	24387(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Upregulation effects of Tanshinone_IIA on the expressions of NeuN , Nissl body , and IkB and downregulation effects on the expressions of GFAP and NF-kB in the brain tissues of rat models of Alzheimer 's _ disease .
24737252	0	Tanshinone_IIA	0,14	HIF-1a	64,70	Tanshinone IIA	HIF-1a	MESH:C021751	3091	Chemical	Gene	blocks|nsubj|START_ENTITY blocks|nmod|downregulation downregulation|compound|END_ENTITY	Tanshinone_IIA blocks epithelial-mesenchymal transition through HIF-1a downregulation , reversing hypoxia-induced chemotherapy resistance in breast_cancer cell lines .
25659153	0	Tanshinone_IIA	0,14	HIF-1a	24,30	Tanshinone IIA	HIF-1a	MESH:C021751	3091	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Tanshinone_IIA inhibits HIF-1a and VEGF expression in breast_cancer cells via mTOR/p70S6K/RPS6 / 4E-BP1 signaling pathway .
19620042	0	Tanshinone_IIA	1,15	MMP-12	49,55	Tanshinone IIA	MMP-12	MESH:C021751	17381(Tax:10090)	Chemical	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|nmod|END_ENTITY	-LSB- Tanshinone_IIA down-regulates the expression of MMP-12 and TF in RAW 264.7 cells -RSB- .
17942126	0	Tanshinone_IIA	0,14	MMP-2	76,81	Tanshinone IIA	MMP-2	MESH:C021751	100009000(Tax:9986)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Tanshinone_IIA inhibits atherosclerotic_plaque formation by down-regulating MMP-2 and MMP-9 expression in rabbits fed a high-fat diet .
21788102	0	Tanshinone_IIA	26,40	MMP-2	100,105	Tanshinone IIA	MMP-2	MESH:C021751	4313	Chemical	Gene	effect|nmod|START_ENTITY involves|nsubj|effect involves|dobj|inhibition inhibition|nmod|TIMP-2 TIMP-2|compound|END_ENTITY	Anti-angiogenic effect of Tanshinone_IIA involves inhibition of matrix invasion and modification of MMP-2 / TIMP-2 secretion in vascular endothelial cells .
26164608	0	Tanshinone_IIA	24,38	NeuN	61,65	Tanshinone IIA	NeuN	MESH:C021751	287847(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Upregulation effects of Tanshinone_IIA on the expressions of NeuN , Nissl body , and IkB and downregulation effects on the expressions of GFAP and NF-kB in the brain tissues of rat models of Alzheimer 's _ disease .
26966780	0	Tanshinone_IIA	0,14	NeuN	35,39	Tanshinone IIA	NeuN	MESH:C021751	287847(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|nmod|END_ENTITY	Tanshinone_IIA increases levels of NeuN , protein disulfide isomerase , and Na + / K + - ATPase and decreases evidence of microglial activation after cerebral ischemic_injury .
20045721	0	Tanshinone_IIA	0,14	STAT3	37,42	Tanshinone IIA	STAT3	MESH:C021751	25125(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|compound|END_ENTITY	Tanshinone_IIA inhibits constitutive STAT3 activation , suppresses proliferation , and induces apoptosis in rat C6 glioma cells .
23358553	0	Tanshinone_IIA	0,14	TCTP	107,111	Tanshinone IIA	TCTP	MESH:C021751	7178	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|expression expression|nmod|END_ENTITY	Tanshinone_IIA inhibits the growth of pancreatic_cancer BxPC -3 cells by decreasing protein expression of TCTP , MCL __ -1 and Bcl __ - xL .
14735448	0	Tanshinone_IIA	0,14	TNF-alpha	110,119	Tanshinone IIA	TNF-alpha	MESH:C021751	21926(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Tanshinone_IIA from Salvia miltiorrhiza inhibits inducible nitric_oxide synthase expression and production of TNF-alpha , IL-1beta and IL-6 in activated RAW 264.7 cells .
19020785	0	Tanshinone_IIA	0,14	TNF-alpha	80,89	Tanshinone IIA	TNF-alpha	MESH:C021751	7124	Chemical	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|nmod|END_ENTITY	Tanshinone_IIA down-regulates the protein expression of ErbB-2 and up-regulates TNF-alpha in colon_cancer cells in vitro and in vivo .
18675798	0	Tanshinone_IIA	11,25	angiotensin_II	83,97	Tanshinone IIA	angiotensin II	MESH:C021751	24179(Tax:10116)	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|apoptosis apoptosis|acl|induced induced|nmod|END_ENTITY	WITHDRAWN : Tanshinone_IIA protects rat cardiomyocytes against apoptosis induced by angiotensin_II in vitro .
26408838	0	Tanshinone_IIA	0,14	angiotensin_II	24,38	Tanshinone IIA	angiotensin II	MESH:C021751	183	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Tanshinone_IIA inhibits angiotensin_II induced extracellular matrix remodeling in human cardiac fibroblasts - Implications for treatment of pathologic cardiac remodeling .
20664954	0	Tanshinone_IIA	0,14	calreticulin	51,63	Tanshinone IIA	calreticulin	MESH:C021751	811	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Tanshinone_IIA inhibits Hep-J5 cells by increasing calreticulin , caspase 12 and GADD153 protein expression .
10630370	0	Tanshinone_IIA	0,14	caspase-3	133,142	Tanshinone IIA	caspase-3	MESH:C021751	836	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Tanshinone_IIA , an ingredient of Salvia miltiorrhiza BUNGE , induces apoptosis in human leukemia cell lines through the activation of caspase-3 .
17640471	0	Tanshinone_IIA	0,14	endothelin-1	24,36	Tanshinone IIA	endothelin-1	MESH:C021751	24323(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Tanshinone_IIA inhibits endothelin-1 production in TNF-alpha-induced brain microvascular endothelial cells through suppression of endothelin-converting_enzyme-1 synthesis .
22032308	0	Tanshinone_IIA	0,14	endothelin-1	48,60	Tanshinone IIA	endothelin-1	MESH:C021751	1906	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|amod|END_ENTITY	Tanshinone_IIA attenuates cyclic strain-induced endothelin-1 expression in human umbilical vein endothelial cells .
17300995	0	Tanshinone_IIA	0,14	heme_oxygenase-1	48,64	Tanshinone IIA	heme oxygenase-1	MESH:C021751	15368(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Tanshinone_IIA from Salvia miltiorrhiza induces heme_oxygenase-1 expression and inhibits lipopolysaccharide-induced nitric_oxide expression in RAW 264.7 cells .
24302760	0	Tanshinone_IIA	0,14	heme_oxygenase-1	81,97	Tanshinone IIA	heme oxygenase-1	MESH:C021751	3162	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|parataxis|role role|nmod|END_ENTITY	Tanshinone_IIA suppresses cholesterol accumulation in human macrophages : role of heme_oxygenase-1 .
21720012	0	Tanshinone_IIA	0,14	macrophage_migration_inhibitory_factor	80,118	Tanshinone IIA	macrophage migration inhibitory factor	MESH:C021751	103694877	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|advcl|inhibiting inhibiting|dobj|END_ENTITY	Tanshinone_IIA attenuates seawater aspiration-induced lung_injury by inhibiting macrophage_migration_inhibitory_factor .
21220930	0	Tanshinone_IIA	0,14	miR-1	24,29	Tanshinone IIA	miR-1	MESH:C021751	100314077(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Tanshinone_IIA inhibits miR-1 expression through p38 MAPK signal pathway in post-infarction rat cardiomyocytes .
20043889	0	Tanshinone_II_A	0,15	RAGE	38,42	Tanshinone II A	RAGE	MESH:C021751	362787(Tax:10116)	Chemical	Gene	HMGB1|compound|START_ENTITY HMGB1|appos|END_ENTITY	Tanshinone_II_A down-regulates HMGB1 , RAGE , TLR4 , NF-kappaB expression , ameliorates BBB permeability and endothelial cell function , and protects rat brains against focal ischemia .
20043889	0	Tanshinone_II_A	0,15	TLR4	44,48	Tanshinone II A	TLR4	MESH:C021751	29260(Tax:10116)	Chemical	Gene	HMGB1|compound|START_ENTITY HMGB1|appos|END_ENTITY	Tanshinone_II_A down-regulates HMGB1 , RAGE , TLR4 , NF-kappaB expression , ameliorates BBB permeability and endothelial cell function , and protects rat brains against focal ischemia .
24662320	0	Tapentadol	0,10	calcitonin_gene-related_peptide	20,51	Tapentadol	calcitonin gene-related peptide	MESH:C523979	24241(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|amod|END_ENTITY	Tapentadol inhibits calcitonin_gene-related_peptide release from rat brainstem in vitro .
17428165	0	Tariquidar	0,10	P-glycoprotein	23,37	Tariquidar	P-glycoprotein	MESH:C402343	5243	Chemical	Gene	START_ENTITY|dep|efflux efflux|amod|END_ENTITY	Tariquidar -LRB- XR9576 -RRB- : a P-glycoprotein drug efflux pump inhibitor .
19034106	0	Tariquidar	0,10	P-glycoprotein	152,166	Tariquidar	P-glycoprotein	MESH:C402343	5243	Chemical	Gene	potentiate|nsubj|START_ENTITY potentiate|nmod|inhibition inhibition|nmod|END_ENTITY	Tariquidar , a selective P-glycoprotein inhibitor , does not potentiate loperamide 's opioid brain effects in humans despite full inhibition of lymphocyte P-glycoprotein .
19034106	0	Tariquidar	0,10	P-glycoprotein	24,38	Tariquidar	P-glycoprotein	MESH:C402343	5243	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Tariquidar , a selective P-glycoprotein inhibitor , does not potentiate loperamide 's opioid brain effects in humans despite full inhibition of lymphocyte P-glycoprotein .
23943604	0	Tariquidar	52,62	P-glycoprotein	102,116	Tariquidar	P-glycoprotein	MESH:C402343	67078(Tax:10090)	Chemical	Gene	Modulators|dobj|START_ENTITY Modulators|nmod|END_ENTITY	Interactions of the Multidrug Resistance Modulators Tariquidar and Elacridar and their Analogues with P-glycoprotein .
25456855	0	Tariquidar	0,10	P-glycoprotein	20,34	Tariquidar	P-glycoprotein	MESH:C402343	5243	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|efflux efflux|amod|END_ENTITY	Tariquidar inhibits P-glycoprotein drug efflux but activates ATPase activity by blocking transition to an open conformation .
26507655	0	Tariquidar	42,52	P-glycoprotein	103,117	Tariquidar	P-glycoprotein	MESH:C402343	5243	Chemical	Gene	Site|nmod|START_ENTITY Mapping|dobj|Site Stabilizes|dep|Mapping Stabilizes|dobj|Domain Domain|nmod|END_ENTITY	Mapping the Binding Site of the Inhibitor Tariquidar that Stabilizes the First Transmembrane Domain of P-glycoprotein .
17826025	0	Taspine	0,7	VEGF	22,26	Taspine	VEGF	MESH:C018394	7422	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	Taspine downregulates VEGF expression and inhibits proliferation of vascular endothelial cells through PI3 kinase and MAP kinase signaling pathways .
21205124	0	Taspoglutide	0,12	GLP-1	40,45	Taspoglutide	GLP-1	MESH:C541736	100125288	Chemical	Gene	START_ENTITY|appos|analogue analogue|compound|END_ENTITY	Taspoglutide , a novel human once-weekly GLP-1 analogue , protects pancreatic b-cells in vitro and preserves islet structure and function in the Zucker_diabetic_fatty rat in vivo .
20470445	0	Tasquinimod	0,11	thrombospondin-1	103,119	Tasquinimod	thrombospondin-1	MESH:C516109	7057	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	Tasquinimod -LRB- ABR-215050 -RRB- , a quinoline-3-carboxamide anti-angiogenic agent , modulates the expression of thrombospondin-1 in human prostate_tumors .
20359515	0	Tau	11,14	TPI	62,65	Tau	TPI	CHEBI:36355	21991(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of Tau on the activity of triose_phosphate_isomerase -LRB- TPI -RRB- in brain cells .
20359515	0	Tau	11,14	triose_phosphate_isomerase	34,60	Tau	triose phosphate isomerase	CHEBI:36355	21991(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	Effects of Tau on the activity of triose_phosphate_isomerase -LRB- TPI -RRB- in brain cells .
26659465	0	Taurine	89,96	CCl4	119,123	Taurine	CCl4	MESH:D013654	116637(Tax:10116)	Chemical	Gene	Actions|nmod|START_ENTITY Actions|nmod|Liver_Damage Liver_Damage|compound|END_ENTITY	Free Radical-Scavenging , Anti-Inflammatory/Anti-Fibrotic and Hepatoprotective Actions of Taurine and Silymarin against CCl4 Induced Rat Liver_Damage .
16937320	0	Taurine	0,7	ERK	94,97	Taurine	ERK	MESH:D013654	26413(Tax:10090)	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|pathway pathway|compound|END_ENTITY	Taurine promotes connective_tissue_growth_factor -LRB- CTGF -RRB- expression in osteoblasts through the ERK signal pathway .
23500209	0	Taurine	0,7	MMP-2	27,32	Taurine	MMP-2	MESH:D013654	100009000(Tax:9986)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Taurine inhibits increased MMP-2 expression in a model of oxidative stress induced by glutathione depletion in rabbit heart .
10973617	0	Taurine	0,7	angiotensin_II	42,56	Taurine	angiotensin II	MESH:D013654	24179(Tax:10116)	Chemical	Gene	induced|nsubj|START_ENTITY induced|nmod|END_ENTITY	Taurine attenuates_hypertrophy induced by angiotensin_II in cultured neonatal rat cardiac myocytes .
17297564	0	Taurine	0,7	caspase-8	16,25	Taurine	caspase-8	MESH:D013654	12370(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|amod|END_ENTITY	Taurine reduces caspase-8 and caspase-9 expression induced by ischemia in the mouse hypothalamic nuclei .
3052459	0	Taurine	0,7	insulin_receptor	32,48	Taurine	insulin receptor	MESH:D013654	3643	Chemical	Gene	START_ENTITY|xcomp|binding binding|nmod|END_ENTITY	Taurine binding to the purified insulin_receptor .
25198400	0	Taurine	0,7	interleukin-6	17,30	Taurine	interleukin-6	MESH:D013654	3569	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Taurine inhibits interleukin-6 expression and release induced by ultraviolet B exposure to human retinal pigment epithelium cells .
23041169	0	Taurine	0,7	mTOR	89,93	Taurine	mTOR	MESH:D013654	21977(Tax:10090)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|nmod|END_ENTITY	Taurine attenuates methamphetamine-induced autophagy and apoptosis in PC12 cells through mTOR signaling pathway .
19915792	0	Taurine	0,7	taurine_transporter	48,67	Taurine	taurine transporter	MESH:D013654	21366(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Taurine inhibits osteoclastogenesis through the taurine_transporter .
21710101	0	Taurine	0,7	taurine_transporter	72,91	Taurine	taurine transporter	MESH:D013654	21366(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|apoptosis apoptosis|nmod|END_ENTITY	Taurine inhibits serum deprivation-induced osteoblast apoptosis via the taurine_transporter / ERK signaling pathway .
25816687	0	Taurine_Chloramine	0,18	Heme_Oxygenase-1	82,98	Taurine Chloramine	Heme Oxygenase-1	MESH:C043410	15368(Tax:10090)	Chemical	Gene	Upregulation|compound|START_ENTITY Upregulation|nmod|Expression Expression|compound|END_ENTITY	Taurine_Chloramine Stimulates Efferocytosis Through Upregulation of Nrf2-Mediated Heme_Oxygenase-1 Expression in Murine Macrophages : Possible Involvement of Carbon_Monoxide .
25833491	0	Taurine_Chloramine	0,18	NFATc1	112,118	Taurine Chloramine	NFATc1	MESH:C043410	4772	Chemical	Gene	Inhibits|nsubj|START_ENTITY Inhibits|nmod|Expression Expression|compound|END_ENTITY	Taurine_Chloramine , a Taurine Metabolite from Activated Neutrophils , Inhibits Osteoclastogenesis by Suppressing NFATc1 Expression .
15309569	0	Taurine_chloramine	0,18	heme_oxygenase-1	48,64	Taurine chloramine	heme oxygenase-1	MESH:C043410	15368(Tax:10090)	Chemical	Gene	START_ENTITY|dep|induce induce|xcomp|END_ENTITY	Taurine_chloramine and taurine_bromamine induce heme_oxygenase-1 in resting and LPS-stimulated J774 .2 macrophages .
20074672	0	Taurine_chloramine	0,18	heme_oxygenase-1	27,43	Taurine chloramine	heme oxygenase-1	MESH:C043410	15368(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Taurine_chloramine induces heme_oxygenase-1 expression via Nrf2 activation in murine macrophages .
17697361	0	Taurine_chloramine	0,18	matrix_metalloproteinase_1	43,69	Taurine chloramine	matrix metalloproteinase 1	MESH:C043410	4312	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Taurine_chloramine differentially inhibits matrix_metalloproteinase_1 and 13 synthesis in interleukin-1beta stimulated fibroblast-like synoviocytes .
26518876	0	Taurocholate	0,12	Cyclooxygenase-2	21,37	Taurocholate	Cyclooxygenase-2	MESH:D013656	5743	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Taurocholate Induces Cyclooxygenase-2 Expression via the Sphingosine_1-phosphate Receptor 2 in a Human_Cholangiocarcinoma Cell Line .
5835386	0	Taurocholate	0,12	cholesterol_esterase	27,47	Taurocholate	cholesterol esterase	MESH:D013656	1056	Chemical	Gene	protection|amod|START_ENTITY protection|nmod|END_ENTITY	Taurocholate protection of cholesterol_esterase against proteolytic inactivation .
22994543	0	Tauroursodeoxycholic_acid	0,25	PPARy	34,39	Tauroursodeoxycholic acid	PPARy	MESH:C031655	5468	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|END_ENTITY	Tauroursodeoxycholic_acid affects PPARy and TLR4 in Steatotic liver transplantation .
18977229	0	Taxanes	0,7	TLR4	22,26	Taxanes	TLR4	MESH:D043823	7099	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|END_ENTITY	Taxanes inhibit human TLR4 signaling by binding to MD-2 .
20419056	0	Taxol	35,40	Androgen_Receptor	14,31	Taxol	Androgen Receptor	MESH:D017239	367	Chemical	Gene	Targeting|nmod|START_ENTITY Targeting|dobj|END_ENTITY	Targeting the Androgen_Receptor by Taxol in Castration-Resistant Prostate_Cancer .
10996845	0	Taxol	0,5	E-cadherin	24,34	Taxol	E-cadherin	MESH:D017239	999	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	Taxol reduces cytosolic E-cadherin and beta-catenin levels in nasopharyngeal_carcinoma cell line TW-039 : cross-talk between the microtubule - and actin-based cytoskeletons .
11500829	0	Taxol	58,63	MyD88	12,17	Taxol	MyD88	MESH:D017239	17874(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of MyD88 and TLR4 in the LPS-mimetic activity of Taxol .
9009167	0	Taxol	0,5	Shc	42,45	Taxol	Shc	MESH:D017239	20416(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Taxol induces tyrosine phosphorylation of Shc and its association with Grb2 in murine RAW 264.7 cells .
10996845	0	Taxol	0,5	TW-039	97,103	Taxol	TW-039	MESH:D017239	1064388(Tax:218496)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|nmod|END_ENTITY	Taxol reduces cytosolic E-cadherin and beta-catenin levels in nasopharyngeal_carcinoma cell line TW-039 : cross-talk between the microtubule - and actin-based cytoskeletons .
8640809	0	Taxol	0,5	bcl-2	14,19	Taxol	bcl-2	MESH:D017239	596	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|amod|END_ENTITY	Taxol induces bcl-2 phosphorylation and death of prostate_cancer cells .
9815595	0	Taxol	0,5	bcl-xL	100,106	Taxol	bcl-xL	MESH:D017239	598	Chemical	Gene	modulation|amod|START_ENTITY modulation|nmod|expression expression|compound|END_ENTITY	Taxol and estramustine-induced modulation of human prostate_cancer cell apoptosis via alteration in bcl-xL and bak expression .
10362110	0	Taxol	87,92	class_III_beta-tubulin	30,52	Taxol	class III beta-tubulin	MESH:D017239	10381	Chemical	Gene	cells|nmod|START_ENTITY cells|amod|END_ENTITY	Antisense oligonucleotides to class_III_beta-tubulin sensitize drug-resistant cells to Taxol .
7517154	0	Taxol	17,22	granulocyte-colony_stimulating_factor	42,79	Taxol	granulocyte-colony stimulating factor	MESH:D017239	1440	Chemical	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Phase I study of Taxol , doxorubicin , plus granulocyte-colony_stimulating_factor in patients with metastatic breast_cancer .
7913412	0	Taxol	0,5	granulocyte-macrophage_colony-stimulating_factor	133,181	Taxol	granulocyte-macrophage colony-stimulating factor	MESH:D017239	12981(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|stabilization stabilization|nmod|RNA RNA|amod|END_ENTITY	Taxol induces the hematopoietic growth factor granulocyte-macrophage_colony-stimulating_factor in murine B-cells by stabilization of granulocyte-macrophage_colony-stimulating_factor nuclear RNA .
7913412	0	Taxol	0,5	granulocyte-macrophage_colony-stimulating_factor	46,94	Taxol	granulocyte-macrophage colony-stimulating factor	MESH:D017239	12981(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Taxol induces the hematopoietic growth factor granulocyte-macrophage_colony-stimulating_factor in murine B-cells by stabilization of granulocyte-macrophage_colony-stimulating_factor nuclear RNA .
12820419	0	Taxol	51,56	thymidine_phosphorylase	13,36	Taxol	thymidine phosphorylase	MESH:D017239	1890	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Induction of thymidine_phosphorylase expression by Taxol does not enhance Furtulon sensitivity in a cisplatin-resistant human ovarian_carcinoma cell line .
12894555	0	Taxol	91,96	thymidine_phosphorylase	13,36	Taxol	thymidine phosphorylase	MESH:D017239	1890	Chemical	Gene	sensitivity|nmod|START_ENTITY sensitivity|nsubj|Induction Induction|nmod|expression expression|amod|END_ENTITY	Induction of thymidine_phosphorylase expression and enhancement of Furtulon sensitivity by Taxol in a human ovarian_carcinoma cell line .
1353517	0	Taxol	0,5	tumor_necrosis_factor_alpha	77,104	Taxol	tumor necrosis factor alpha	MESH:D017239	21926(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Taxol , a microtubule-stabilizing antineoplastic agent , induces expression of tumor_necrosis_factor_alpha and interleukin-1 in macrophages .
26937021	0	Tazarotenic_Acid	18,34	CYP26A1	104,111	Tazarotenic Acid	CYP26A1	CHEBI:73129	1592	Chemical	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of Tazarotenic_Acid as the First Xenobiotic Substrate of Human Retinoic_Acid Hydroxylase CYP26A1 and CYP26B1 .
21776411	0	TbR-I	73,78	eEF1A1	63,69	TbR-I	eEF1A1	null	1915	Chemical	Gene	synthesis|amod|START_ENTITY END_ENTITY|nmod|synthesis	Translational connection of TGFb signaling : Phosphorylation of eEF1A1 by TbR-I inhibits protein synthesis .
10832087	0	Tc-99m-tetrofosmin	76,94	MRP	61,64	Tc-99m-tetrofosmin	MRP	MESH:C078700	4363	Chemical	Gene	protein|nmod|START_ENTITY protein|compound|END_ENTITY	Involvement of the glutathione_S-conjugate compounds and the MRP protein in Tc-99m-tetrofosmin and Tc-99m-sestamibi uptake in glioma cell lines .
8790223	0	Technetium-99m-tetrofosmin	0,26	P-glycoprotein	46,60	Technetium-99m-tetrofosmin	P-glycoprotein	MESH:C078700	5243	Chemical	Gene	START_ENTITY|nmod|substrate substrate|nmod|END_ENTITY	Technetium-99m-tetrofosmin as a substrate for P-glycoprotein : in vitro studies in multidrug-resistant breast_tumor cells .
11279794	0	Technetium-99m-tetrofosmin	0,26	multidrug_resistance-associated_protein	52,91	Technetium-99m-tetrofosmin	multidrug resistance-associated protein	MESH:C078700	8714	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Technetium-99m-tetrofosmin would be a substrate for multidrug_resistance-associated_protein -LRB- MRP -RRB- : comparison between a leukemia cell line with high MRP gene expression and its parental cell line .
11105826	0	Technetium-99m_RP527	0,20	GRP	24,27	Technetium-99m RP527	GRP	MESH:C420883	2922	Chemical	Gene	START_ENTITY|appos|analogue analogue|compound|END_ENTITY	Technetium-99m_RP527 , a GRP analogue for visualisation of GRP receptor-expressing malignancies : a feasibility study .
19326083	0	Tectoridin	0,10	estrogen_receptor_alpha	29,52	Tectoridin	estrogen receptor alpha	MESH:C120040	2099	Chemical	Gene	START_ENTITY|appos|ligand ligand|nmod|END_ENTITY	Tectoridin , a poor ligand of estrogen_receptor_alpha , exerts its estrogenic effects via an ERK-dependent pathway .
16099790	0	Teduglutide	0,11	glucagon-like_peptide_2	60,83	Teduglutide	glucagon-like peptide 2	MESH:C494910	2641	Chemical	Gene	START_ENTITY|appos|analogue analogue|amod|END_ENTITY	Teduglutide -LRB- ALX-0600 -RRB- , a dipeptidyl_peptidase_IV resistant glucagon-like_peptide_2 analogue , improves intestinal function in short_bowel_syndrome patients .
25512630	0	Telaprevir	98,108	CXCL10	28,34	Telaprevir	CXCL10	MESH:C486464	3627	Chemical	Gene	Treated|nmod|START_ENTITY Treated|nsubj|Expression Expression|compound|END_ENTITY	Intrahepatic and Peripheral CXCL10 Expression in Hepatitis_C_Virus-Infected Patients Treated With Telaprevir , Pegylated Interferon , and Ribavirin .
24332840	0	Telaprevir	0,10	P-glycoprotein	52,66	Telaprevir	P-glycoprotein	MESH:C486464	5243	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Telaprevir is a substrate and moderate inhibitor of P-glycoprotein , a strong inductor of ABCG2 , but not an activator of PXR in vitro .
19200908	0	Telmisartan	0,11	ACE	48,51	Telmisartan	ACE	MESH:C084178	1636	Chemical	Gene	START_ENTITY|nmod|intolerant intolerant|nmod|END_ENTITY	Telmisartan in high-risk patients intolerant of ACE inhibitors .
19200909	0	Telmisartan	0,11	ACE	48,51	Telmisartan	ACE	MESH:C084178	1636	Chemical	Gene	START_ENTITY|nmod|intolerant intolerant|nmod|END_ENTITY	Telmisartan in high-risk patients intolerant of ACE inhibitors .
19200910	0	Telmisartan	0,11	ACE	48,51	Telmisartan	ACE	MESH:C084178	1636	Chemical	Gene	START_ENTITY|nmod|intolerant intolerant|nmod|END_ENTITY	Telmisartan in high-risk patients intolerant of ACE inhibitors .
19770395	0	Telmisartan	222,233	ACE	265,268	Telmisartan	ACE	MESH:C084178	1636	Chemical	Gene	Study|compound|START_ENTITY Study|nmod|Subjects Subjects|compound|END_ENTITY	Effects of telmisartan , ramipril , and their combination on left_ventricular_hypertrophy in individuals at high vascular risk in the Ongoing Telmisartan_Alone and in Combination With Ramipril Global End Point Trial and the Telmisartan Randomized Assessment Study in ACE Intolerant Subjects With Cardiovascular_Disease .
23247798	0	Telmisartan	0,11	Abcb4	97,102	Telmisartan	Abcb4	MESH:C084178	18670(Tax:10090)	Chemical	Gene	improves|nsubj|START_ENTITY improves|nmod|END_ENTITY	Telmisartan plus propranolol improves liver_fibrosis and bile duct proliferation in the PSC-like Abcb4 - / - mouse model .
18633177	0	Telmisartan	188,199	Angiotensin_II	164,178	Telmisartan	Angiotensin II	MESH:C084178	183	Chemical	Gene	Investigation|appos|START_ENTITY Investigation|compound|END_ENTITY	Microalbuminuria reduction with telmisartan in normotensive and hypertensive Japanese patients with type 2 diabetes : a post-hoc analysis of The Incipient to Overt : Angiotensin_II Blocker , Telmisartan , Investigation on Type 2 Diabetic_Nephropathy -LRB- INNOVATION -RRB- study .
23675001	0	Telmisartan	52,63	Angiotensin_II	3,17	Telmisartan	Angiotensin II	MESH:C084178	11606(Tax:10090)	Chemical	Gene	Resistance|appos|START_ENTITY Type|dobj|Resistance Type|nsubj|END_ENTITY	An Angiotensin_II -LRB- Ang_II -RRB- Type 1 Receptor Blocker , Telmisartan , Improves Insulin Resistance in KK-A -LRB- y -RRB- Diabetic Mice .
17004092	0	Telmisartan	0,11	C-reactive_protein	33,51	Telmisartan	C-reactive protein	MESH:C084178	1401	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Telmisartan inhibits AGE-induced C-reactive_protein production through downregulation of the receptor for AGE via peroxisome proliferator-activated receptor-gamma activation .
23675001	0	Telmisartan	52,63	Insulin	74,81	Telmisartan	Insulin	MESH:C084178	3630	Chemical	Gene	Resistance|appos|START_ENTITY Resistance|compound|END_ENTITY	An Angiotensin_II -LRB- Ang_II -RRB- Type 1 Receptor Blocker , Telmisartan , Improves Insulin Resistance in KK-A -LRB- y -RRB- Diabetic Mice .
25649195	0	Telmisartan	47,58	Insulin	86,93	Telmisartan	Insulin	MESH:C084178	3630	Chemical	Gene	Study|nmod|START_ENTITY Study|advcl|Improving Improving|dobj|Resistance Resistance|compound|END_ENTITY	Open-label , Randomized Crossover Study Between Telmisartan and Valsartan on Improving Insulin Resistance and Adipocytokines in Nondiabetic Patients with Mild Hypertension .
16915040	0	Telmisartan	0,11	MAC-1	36,41	Telmisartan	MAC-1	MESH:C084178	3689	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Telmisartan inhibits beta2-integrin MAC-1 expression in human T-lymphocytes .
17587765	0	Telmisartan	0,11	PPARgamma	77,86	Telmisartan	PPARgamma	MESH:C084178	5468	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|advcl|activating activating|dobj|END_ENTITY	Telmisartan enhances cholesterol efflux from THP-1 macrophages by activating PPARgamma .
26435412	0	Telmisartan	93,104	Serum_Amyloid_A1	22,38	Telmisartan	Serum Amyloid A1	MESH:C084178	20208(Tax:10090)	Chemical	Gene	Induced|nmod|START_ENTITY Induced|nsubjpass|Expression Expression|nmod|END_ENTITY	Hepatic Expression of Serum_Amyloid_A1 Is Induced by Traumatic_Brain_Injury and Modulated by Telmisartan .
22949934	0	Telmisartan	0,11	TGF-b1	24,30	Telmisartan	TGF-b1	MESH:C084178	7040	Chemical	Gene	counteracts|nsubj|START_ENTITY counteracts|dobj|END_ENTITY	Telmisartan counteracts TGF-b1 induced epithelial-to-mesenchymal transition via PPAR-y in human proximal tubule epithelial cells .
26455386	0	Telmisartan	0,11	VCAM-1	49,55	Telmisartan	VCAM-1	MESH:C084178	7412	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|compound|END_ENTITY	Telmisartan attenuates hyperglycemia-exacerbated VCAM-1 expression and monocytes adhesion in TNFa-stimulated endothelial cells by inhibiting IKKb expression .
25450396	0	Telmisartan	0,11	VEGF-C	66,72	Telmisartan	VEGF-C	MESH:C084178	7424	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|production production|amod|END_ENTITY	Telmisartan , a possible PPAR - agonist , reduces TNF-a-stimulated VEGF-C production by inhibiting the p38MAPK/HSP27 pathway in human proximal renal tubular cells .
18633170	0	Telmisartan	0,11	adiponectin	40,51	Telmisartan	adiponectin	MESH:C084178	9370	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|expression expression|compound|END_ENTITY	Telmisartan but not candesartan affects adiponectin expression in vivo and in vitro .
22821644	0	Telmisartan	0,11	adiponectin	57,68	Telmisartan	adiponectin	MESH:C084178	9370	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|compound|END_ENTITY	Telmisartan at 80 mg/day increases high-molecular-weight adiponectin levels and improves insulin resistance in diabetic patients .
17697525	0	Telmisartan	0,11	angiotensin_II	16,30	Telmisartan	angiotensin II	MESH:C084178	183	Chemical	Gene	START_ENTITY|appos|blocker blocker|compound|END_ENTITY	Telmisartan , an angiotensin_II type 1 receptor blocker , inhibits advanced glycation end-product -LRB- AGE -RRB- - induced monocyte_chemoattractant_protein-1 expression in mesangial cells through downregulation of receptor for AGEs via peroxisome_proliferator-activated_receptor-gamma activation .
20888384	0	Telmisartan	0,11	angiotensin_II	97,111	Telmisartan	angiotensin II	MESH:C084178	24179(Tax:10116)	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|nmod|alteration alteration|nmod|expression expression|compound|END_ENTITY	Telmisartan prevents the progression of renal_injury in daunorubicin rats with the alteration of angiotensin_II and endothelin-1 receptor expression associated with its PPAR-y agonist actions .
15864875	0	Telmisartan	0,11	angiotensin_II_type_1_receptor	104,134	Telmisartan	angiotensin II type 1 receptor	MESH:C084178	185	Chemical	Gene	has|nsubj|START_ENTITY has|dobj|affinity affinity|dep|comparison comparison|nmod|blockers blockers|amod|END_ENTITY	Telmisartan has the strongest binding affinity to angiotensin_II_type_1_receptor : comparison with other angiotensin_II_type_1_receptor blockers .
15864875	0	Telmisartan	0,11	angiotensin_II_type_1_receptor	50,80	Telmisartan	angiotensin II type 1 receptor	MESH:C084178	185	Chemical	Gene	has|nsubj|START_ENTITY has|dobj|affinity affinity|nmod|END_ENTITY	Telmisartan has the strongest binding affinity to angiotensin_II_type_1_receptor : comparison with other angiotensin_II_type_1_receptor blockers .
16938288	0	Telmisartan	0,11	angiotensin_II_type_1_receptor	26,56	Telmisartan	angiotensin II type 1 receptor	MESH:C084178	81638(Tax:10116)	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	Telmisartan downregulates angiotensin_II_type_1_receptor through activation of peroxisome_proliferator-activated_receptor_gamma .
17410441	0	Telmisartan	0,11	angiotensin_II_type_1_receptor	16,46	Telmisartan	angiotensin II type 1 receptor	MESH:C084178	81638(Tax:10116)	Chemical	Gene	START_ENTITY|appos|blocker blocker|amod|END_ENTITY	Telmisartan , an angiotensin_II_type_1_receptor blocker , controls progress of nonalcoholic_steatohepatitis in rats .
19171132	0	Telmisartan	0,11	angiotensin_II_type_1_receptor	16,46	Telmisartan	angiotensin II type 1 receptor	MESH:C084178	81638(Tax:10116)	Chemical	Gene	START_ENTITY|appos|blocker blocker|amod|END_ENTITY	Telmisartan , an angiotensin_II_type_1_receptor blocker , prevents the development of diabetes in male Spontaneously Diabetic Torii rats .
19292980	0	Telmisartan	0,11	angiotensin_II_type_1_receptor	16,46	Telmisartan	angiotensin II type 1 receptor	MESH:C084178	81638(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Telmisartan , an angiotensin_II_type_1_receptor antagonist , attenuates T-type Ca2 + channel expression in neonatal rat cardiomyocytes .
22953357	0	Telmisartan	14,25	angiotensin_II_type_1_receptor	30,60	Telmisartan	angiotensin II type 1 receptor	MESH:C084178	185	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	-LRB- 11 -RRB- C-Labeled Telmisartan , an angiotensin_II_type_1_receptor antagonist Angiotensin_II _ -LRB- Ang_II -RRB- , a product of the renin-angiotensin system , mediates the activity of this system primarily through two receptors : the Ang_II_type_1_receptor -LRB- AT1R -RRB- and the Ang II type 2 receptor -LRB- AT2R -RRB- -LRB- 1 -RRB- .
20883237	0	Telmisartan	0,11	insulin	23,30	Telmisartan	insulin	MESH:C084178	3630	Chemical	Gene	effects|nsubj|START_ENTITY effects|nmod|resistance resistance|compound|END_ENTITY	Telmisartan effects on insulin resistance in obese or overweight adults without diabetes or hypertension .
24067162	0	Telmisartan	0,11	lipoprotein_lipase	22,40	Telmisartan	lipoprotein lipase	MESH:C084178	16956(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Telmisartan increases lipoprotein_lipase expression via peroxisome proliferator-activated receptor-alpha in HepG2 cells .
23238297	0	Telmisartan	0,11	peroxisome_proliferator-activated_receptor	67,109	Telmisartan	peroxisome proliferator-activated receptor	MESH:C084178	19013(Tax:10090)	Chemical	Gene	improves|nsubj|START_ENTITY improves|nmod|END_ENTITY	Telmisartan improves insulin resistance of skeletal muscle through peroxisome_proliferator-activated_receptor - activation .
17697525	0	Telmisartan	0,11	peroxisome_proliferator-activated_receptor-gamma	223,271	Telmisartan	peroxisome proliferator-activated receptor-gamma	MESH:C084178	5468	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|end-product end-product|acl:relcl|induced induced|nmod|downregulation downregulation|nmod|receptor receptor|nmod|AGEs AGEs|nmod|activation activation|amod|END_ENTITY	Telmisartan , an angiotensin_II type 1 receptor blocker , inhibits advanced glycation end-product -LRB- AGE -RRB- - induced monocyte_chemoattractant_protein-1 expression in mesangial cells through downregulation of receptor for AGEs via peroxisome_proliferator-activated_receptor-gamma activation .
18475159	0	Telmisartan	0,11	peroxisome_proliferator-activated_receptor-gamma	72,120	Telmisartan	peroxisome proliferator-activated receptor-gamma	MESH:C084178	25664(Tax:10116)	Chemical	Gene	increases|compound|START_ENTITY fatty_acid|nsubj|increases fatty_acid|nmod|pathway pathway|amod|END_ENTITY	Telmisartan increases fatty_acid oxidation in skeletal muscle through a peroxisome_proliferator-activated_receptor-gamma dependent pathway .
19590508	0	Telmisartan	0,11	peroxisome_proliferator-activated_receptor-gamma	92,140	Telmisartan	peroxisome proliferator-activated receptor-gamma	MESH:C084178	5468	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	Telmisartan inhibits cytokine-induced nuclear factor-kappaB activation independently of the peroxisome_proliferator-activated_receptor-gamma .
16938288	0	Telmisartan	0,11	peroxisome_proliferator-activated_receptor_gamma	79,127	Telmisartan	peroxisome proliferator-activated receptor gamma	MESH:C084178	25664(Tax:10116)	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|nmod|activation activation|nmod|END_ENTITY	Telmisartan downregulates angiotensin_II_type_1_receptor through activation of peroxisome_proliferator-activated_receptor_gamma .
20637184	0	Telmisartan	0,11	peroxisome_proliferator-activated_receptor_gamma	34,82	Telmisartan	peroxisome proliferator-activated receptor gamma	MESH:C084178	25664(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|nmod|END_ENTITY	Telmisartan , a partial agonist of peroxisome_proliferator-activated_receptor_gamma , improves impairment_of_spatial_memory and hippocampal apoptosis in rats treated with repeated cerebral_ischemia .
16271939	0	Telmisartan	0,11	receptor_for_advanced_glycation_end_products	37,81	Telmisartan	receptor for advanced glycation end products	MESH:C084178	177	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Telmisartan inhibits expression of a receptor_for_advanced_glycation_end_products -LRB- RAGE -RRB- in angiotensin-II-exposed endothelial cells and decreases serum levels of soluble RAGE in patients with essential hypertension .
19008718	0	Telmisartan	0,11	renin	48,53	Telmisartan	renin	MESH:C084178	5972	Chemical	Gene	improves|nsubj|START_ENTITY improves|nmod|END_ENTITY	Telmisartan improves insulin resistance in high renin nonmodulating salt-sensitive hypertensives .
9067317	0	Temocaprilat	0,12	angiotensin-converting_enzyme	22,51	Temocaprilat	angiotensin-converting enzyme	MESH:C069156	24310(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Temocaprilat , a novel angiotensin-converting_enzyme inhibitor , is excreted in bile via an ATP-dependent active transporter -LRB- cMOAT -RRB- that is deficient in Eisai hyperbilirubinemic mutant rats -LRB- EHBR -RRB- .
24811082	0	Temozolomide	32,44	Bak	0,3	Temozolomide	Bak	MESH:C047246	578	Chemical	Gene	essential|nmod|START_ENTITY essential|nsubj|END_ENTITY	Bak and Mcl-1 are essential for Temozolomide induced cell death in human glioma .
25053824	0	Temozolomide	0,12	Epidermal_Growth_Factor	39,62	Temozolomide	Epidermal Growth Factor	MESH:C047246	13645(Tax:10090)	Chemical	Gene	Induces|nsubj|START_ENTITY Induces|dobj|Production Production|nmod|END_ENTITY	Temozolomide Induces the Production of Epidermal_Growth_Factor to Regulate MDR1 Expression in Glioblastoma Cells .
25053824	0	Temozolomide	0,12	MDR1	75,79	Temozolomide	MDR1	MESH:C047246	18669(Tax:10090)	Chemical	Gene	Induces|nsubj|START_ENTITY Induces|nmod|Expression Expression|compound|END_ENTITY	Temozolomide Induces the Production of Epidermal_Growth_Factor to Regulate MDR1 Expression in Glioblastoma Cells .
19127257	0	Temozolomide	0,12	MGMT	103,107	Temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	apoptosis|amod|START_ENTITY apoptosis|dep|response response|acl|related related|nmod|DSBs DSBs|compound|END_ENTITY	Temozolomide - and fotemustine-induced apoptosis in human malignant_melanoma cells : response related to MGMT , MMR , DSBs , and p53 .
19514084	0	Temozolomide	0,12	MGMT	110,114	Temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	concomitant|amod|START_ENTITY concomitant|dep|correlation correlation|nmod|status status|amod|END_ENTITY	Temozolomide concomitant and adjuvant to radiotherapy in elderly patients with glioblastoma : correlation with MGMT promoter methylation status .
20668043	0	Temozolomide	0,12	MGMT	131,135	Temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	treatment|amod|START_ENTITY treatment|dep|promoter promoter|appos|END_ENTITY	Temozolomide treatment for aggressive pituitary_tumors : correlation of clinical outcome with O -LRB- 6 -RRB- - methylguanine_methyltransferase -LRB- MGMT -RRB- promoter methylation and expression .
21405945	0	Temozolomide	0,12	MGMT	68,72	Temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	induced|nsubj|START_ENTITY induced|dobj|apoptosis apoptosis|nmod|Akt Akt|acl|signalling signalling|nmod|END_ENTITY	Temozolomide induced c-Myc-mediated apoptosis via Akt signalling in MGMT expressing glioblastoma cells .
22837675	0	Temozolomide	113,125	MGMT	36,40	Temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	Correlated|xcomp|START_ENTITY Correlated|dep|END_ENTITY	O6-Methylguanine-Methyltransferase -LRB- MGMT -RRB- Promoter Methylation Status in Glioma Stem-Like Cells is Correlated to Temozolomide Sensitivity Under Differentiation-Promoting Conditions .
25655102	0	Temozolomide	93,105	MGMT	0,4	Temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	Rechallenge|compound|START_ENTITY Benefit|nmod|Rechallenge Biomarker|nmod|Benefit Biomarker|nsubj|Methylation Methylation|compound|END_ENTITY	MGMT Promoter Methylation Is a Strong Prognostic Biomarker for Benefit from Dose-Intensified Temozolomide Rechallenge in Progressive Glioblastoma : The DIRECTOR Trial .
25777962	0	Temozolomide	53,65	MGMT	0,4	Temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	Predicts|nmod|START_ENTITY Predicts|nsubj|Expression Expression|compound|END_ENTITY	MGMT Expression Predicts PARP-Mediated Resistance to Temozolomide .
26305586	0	Temozolomide	0,12	MGMT	79,83	Temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|expression expression|compound|END_ENTITY	Temozolomide treatment for pediatric refractory anaplastic_ependymoma with low MGMT protein expression .
26305586	0	Temozolomide	0,12	MGMT	79,83	Temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|expression expression|compound|END_ENTITY	Temozolomide treatment for pediatric refractory anaplastic_ependymoma with low MGMT protein expression .
26447477	0	Temozolomide	0,12	MGMT	67,71	Temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	Resistance|amod|START_ENTITY Resistance|dep|Implication Implication|nmod|Expression Expression|compound|END_ENTITY	Temozolomide Resistance in Glioblastoma Cell Lines : Implication of MGMT , MMR , P-Glycoprotein and CD133 Expression .
26682634	0	Temozolomide	204,216	MGMT	72,76	Temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|analysis analysis|nmod|expression expression|amod|O6-methylguanine-DNA_methyltransferase O6-methylguanine-DNA_methyltransferase|dep|END_ENTITY	Immunohistochemical analysis of O6-methylguanine-DNA_methyltransferase -LRB- MGMT -RRB- protein expression as prognostic marker in glioblastoma patients treated with radiation therapy with concomitant and adjuvant Temozolomide .
23897632	0	Temozolomide	0,12	P-glycoprotein	27,41	Temozolomide	P-glycoprotein	MESH:C047246	5243	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	Temozolomide downregulates P-glycoprotein expression in glioblastoma stem cells by interfering with the Wnt3a/glycogen _ synthase-3_kinase / b-catenin pathway .
26530267	0	Temozolomide	0,12	P-glycoprotein	59,73	Temozolomide	P-glycoprotein	MESH:C047246	287115(Tax:10116)	Chemical	Gene	reverses|nsubj|START_ENTITY reverses|advcl|inhibiting inhibiting|dobj|END_ENTITY	Temozolomide reverses doxorubicin resistance by inhibiting P-glycoprotein in malignant_glioma cells .
26505995	0	Temozolomide	37,49	PARP	16,20	Temozolomide	PARP	MESH:C047246	142	Chemical	Gene	Trapping|compound|START_ENTITY Inhibitors|nmod|Trapping Inhibitors|compound|END_ENTITY	Combinations of PARP Inhibitors with Temozolomide Drive PARP1 Trapping and Apoptosis in Ewing 's _ Sarcoma .
26647409	0	Temozolomide	56,68	Presenilin_1	83,95	Temozolomide	Presenilin 1	MESH:C047246	29192(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|Expression Expression|compound|END_ENTITY	HIF-1a Inhibition Sensitized Pituitary_Adenoma Cells to Temozolomide by Regulating Presenilin_1 Expression and Autophagy .
26972001	0	Temozolomide	43,55	Retinoblastoma_Binding_Protein_4	0,32	Temozolomide	Retinoblastoma Binding Protein 4	MESH:C047246	5928	Chemical	Gene	Sensitivity|compound|START_ENTITY Sensitivity|compound|END_ENTITY	Retinoblastoma_Binding_Protein_4 Modulates Temozolomide Sensitivity in Glioblastoma by Regulating DNA Repair Proteins .
21461172	0	Temozolomide	0,12	caveolin-1	22,32	Temozolomide	caveolin-1	MESH:C047246	857	Chemical	Gene	modifies|nsubj|START_ENTITY modifies|dobj|expression expression|amod|END_ENTITY	Temozolomide modifies caveolin-1 expression in experimental malignant_gliomas in vitro and in vivo .
24303044	0	Temozolomide	76,88	elongation_factor-2_kinase	14,40	Temozolomide	elongation factor-2 kinase	MESH:C047246	29904	Chemical	Gene	activity|nmod|START_ENTITY augments|dobj|activity augments|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of elongation_factor-2_kinase augments the antitumor activity of Temozolomide against glioma .
12491513	0	Temozolomide	0,12	interferon_alpha-2b	33,52	Temozolomide	interferon alpha-2b	MESH:C047246	3440	Chemical	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	Temozolomide in combination with interferon_alpha-2b in patients with metastatic_melanoma : a phase I dose-escalation study .
20130512	0	Temozolomide	0,12	o6-methylguanine_DNA_methyltransferase	83,121	Temozolomide	o6-methylguanine DNA methyltransferase	MESH:C047246	4255	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Temozolomide in advanced and recurrent uterine_leiomyosarcoma and correlation with o6-methylguanine_DNA_methyltransferase expression : a case series .
18676330	0	Temsirolimus	0,12	mTOR	17,21	Temsirolimus	mTOR	MESH:C401859	21977(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Temsirolimus , an mTOR inhibitor for treatment of patients with advanced_renal_cell_carcinoma .
21285988	0	Temsirolimus	0,12	mTOR	17,21	Temsirolimus	mTOR	MESH:C401859	21977(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Temsirolimus , an mTOR inhibitor , enhances anti-tumour effects of heat_shock_protein cancer vaccines .
22082314	0	Temsirolimus	0,12	mTOR	17,21	Temsirolimus	mTOR	MESH:C401859	21977(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Temsirolimus , an mTOR inhibitor , in combination with lower-dose clofarabine as salvage therapy for older patients with acute_myeloid_leukaemia : results of a phase II GIMEMA study -LRB- AML-1107 -RRB- .
24767255	0	Temsirolimus	0,12	mTOR	18,22	Temsirolimus	mTOR	MESH:C401859	21977(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Temsirolimus , the mTOR inhibitor , induces autophagy in adenoid_cystic_carcinoma : In vitro and in vivo .
18316545	0	Temsirolimus	0,12	mammalian_target_of_rapamycin	30,59	Temsirolimus	mammalian target of rapamycin	MESH:C401859	2475	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Temsirolimus , an inhibitor of mammalian_target_of_rapamycin .
21301319	0	Temsirolimus	0,12	mammalian_target_of_rapamycin	106,135	Temsirolimus	mammalian target of rapamycin	MESH:C401859	2475	Chemical	Gene	START_ENTITY|dep|patterns patterns|nmod|activation activation|nmod|pathway pathway|compound|END_ENTITY	Temsirolimus in advanced_leiomyosarcomas : patterns of response and correlation with the activation of the mammalian_target_of_rapamycin pathway .
18343280	0	Temsirolimus	0,12	p21	27,30	Temsirolimus	p21	MESH:C401859	644914	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	Temsirolimus downregulates p21 without altering cyclin_D1 expression and induces autophagy and synergizes with vorinostat in mantle_cell_lymphoma .
23671395	0	Teneligliptin	0,13	DPP-4	17,22	Teneligliptin	DPP-4	MESH:C579035	1803	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Teneligliptin : a DPP-4 inhibitor for the treatment of type 2 diabetes .
25368904	0	Teneligliptin	16,29	DPP-4	0,5	Teneligliptin	DPP-4	MESH:C579035	1803	Chemical	Gene	Resistance|compound|START_ENTITY Resistance|compound|END_ENTITY	DPP-4 Inhibitor Teneligliptin Improves Insulin Resistance and Serum Lipid Profile in Japanese Patients with Type 2 Diabetes .
26340762	0	Teneligliptin	80,93	DPP-4	62,67	Teneligliptin	DPP-4	MESH:C579035	25253(Tax:10116)	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|profile profile|nmod|END_ENTITY	Pharmacokinetic and protein binding profile of peptidomimetic DPP-4 inhibitor - Teneligliptin in rats using liquid chromatography-tandem mass spectrometry .
26224337	0	Teneligliptin	0,13	Dipeptidyl_Peptidase-4	17,39	Teneligliptin	Dipeptidyl Peptidase-4	MESH:C579035	1803	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|compound|END_ENTITY	Teneligliptin , a Dipeptidyl_Peptidase-4 Inhibitor , Improves Early-Phase Insulin Secretion in Drug-Na ve Patients with Type 2 Diabetes .
26670228	0	Teneligliptin	37,50	Dipeptidyl_Peptidase-4	4,26	Teneligliptin	Dipeptidyl Peptidase-4	MESH:C579035	13482(Tax:10090)	Chemical	Gene	Lipogenesis|compound|START_ENTITY END_ENTITY|dep|Lipogenesis	The Dipeptidyl_Peptidase-4 Inhibitor Teneligliptin Attenuates Hepatic Lipogenesis via AMPK Activation in Non-Alcoholic Fatty Liver_Disease Model Mice .
25368904	0	Teneligliptin	16,29	Insulin	39,46	Teneligliptin	Insulin	MESH:C579035	3630	Chemical	Gene	Resistance|compound|START_ENTITY Resistance|compound|END_ENTITY	DPP-4 Inhibitor Teneligliptin Improves Insulin Resistance and Serum Lipid Profile in Japanese Patients with Type 2 Diabetes .
17127497	0	Terbutaline	0,11	corticotropin-releasing_hormone	21,52	Terbutaline	corticotropin-releasing hormone	MESH:D013726	1392	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Terbutaline inhibits corticotropin-releasing_hormone -LRB- CRH -RRB- expression in human trophoblast cells .
11522045	0	Terguride	0,9	prolactin	21,30	Terguride	prolactin	MESH:C006208	24683(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|levels levels|compound|END_ENTITY	Terguride attenuates prolactin levels and ameliorates_insulin_sensitivity and insulin binding in obese spontaneously hypertensive rats .
18494002	0	Teriparatide	0,12	PTH	25,28	Teriparatide	PTH	MESH:D019379	5741	Chemical	Gene	regulation|amod|START_ENTITY regulation|appos|END_ENTITY	Teriparatide -LRB- 1-34 human PTH -RRB- regulation of osterix during fracture repair .
18494002	0	Teriparatide	0,12	osterix	44,51	Teriparatide	osterix	MESH:D019379	121340	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Teriparatide -LRB- 1-34 human PTH -RRB- regulation of osterix during fracture repair .
12395316	0	Terlipressin	0,12	iNOS	37,41	Terlipressin	iNOS	MESH:C012078	24599(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|expression expression|compound|END_ENTITY	Terlipressin inhibits in vivo aortic iNOS expression induced by lipopolysaccharide in rats with biliary_cirrhosis .
22921855	0	Terlipressin	0,12	vascular_endothelial_growth_factor	23,57	Terlipressin	vascular endothelial growth factor	MESH:C012078	7422	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|compound|END_ENTITY	Terlipressin decreases vascular_endothelial_growth_factor expression and improves oxygenation in patients with acute_respiratory_distress_syndrome and shock .
17148649	0	Terlipressin	0,12	vasopressin	14,25	Terlipressin	vasopressin	MESH:C012078	551	Chemical	Gene	START_ENTITY|dep|analog analog|compound|END_ENTITY	Terlipressin : vasopressin analog and novel drug for septic_shock .
23261604	0	Terpendole_E	0,12	Eg5	24,27	Terpendole E	Eg5	MESH:C477863	3832	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Terpendole_E , a kinesin Eg5 inhibitor , is a key biosynthetic intermediate of indole-diterpenes in the producing fungus Chaunopycnis alba .
24648249	0	Terpendole_E	0,12	Eg5	66,69	Terpendole E	Eg5	MESH:C477863	3832	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|END_ENTITY	Terpendole_E and its derivative inhibit STLC - and GSK-1-resistant Eg5 .
20145250	0	Terpestacin	0,11	UQCRB	53,58	Terpestacin	UQCRB	MESH:C080890	7381	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	Terpestacin inhibits tumor angiogenesis by targeting UQCRB of mitochondrial complex III and suppressing hypoxia-induced reactive oxygen species production and cellular oxygen sensing .
10230611	0	Terphenyl	0,9	cyclooxygenase-2	10,26	Terphenyl	cyclooxygenase-2	null	5743	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Terphenyl cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors : optimization of the central ring and o-biphenyl analogs .
19243281	0	Tesamorelin	0,11	growth_hormone_releasing_factor	21,52	Tesamorelin	growth hormone releasing factor	MESH:C479538	2691	Chemical	Gene	START_ENTITY|appos|analogue analogue|compound|END_ENTITY	Tesamorelin , a human growth_hormone_releasing_factor analogue .
7358215	0	Testosterone	0,12	5_alpha-reductase	13,30	Testosterone	5 alpha-reductase	MESH:D013739	6715	Chemical	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Testosterone 5_alpha-reductase activity of skin fibroblasts .
10641051	0	Testosterone	0,12	5alpha-reductase	13,29	Testosterone	5alpha-reductase	MESH:D013739	6715	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Testosterone 5alpha-reductase inhibitor bisnaphthoquinone derivative from Impatiens balsamina .
24995161	0	Testosterone	52,64	AKR1C3	41,47	Testosterone	AKR1C3	MESH:D013739	8644	Chemical	Gene	Activity|nmod|START_ENTITY Activity|appos|Inhibitor Inhibitor|nmod|END_ENTITY	The Activity of SN33638 , an Inhibitor of AKR1C3 , on Testosterone and 17b-Estradiol Production and Function in Castration-Resistant Prostate Cancer and ER-Positive Breast_Cancer .
25512346	0	Testosterone	0,12	AT1R	21,25	Testosterone	AT1R	MESH:D013739	24180(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|compound|END_ENTITY	Testosterone reduces AT1R expression to prevent b-cell and islet apoptosis from glucotoxicity .
24454369	0	Testosterone	82,94	Androgen_Receptor	0,17	Testosterone	Androgen Receptor	MESH:D013739	367	Chemical	Gene	Therapy|compound|START_ENTITY Effects|nmod|Therapy Regulates|dobj|Effects Regulates|nsubj|Polymorphism Polymorphism|compound|END_ENTITY	Androgen_Receptor Gene CAG Repeat Polymorphism Regulates the Metabolic Effects of Testosterone Replacement Therapy in Male Postsurgical Hypogonadotropic_Hypogonadism .
25443437	0	Testosterone	82,94	Androgen_Receptor	13,30	Testosterone	Androgen Receptor	MESH:D013739	367	Chemical	Gene	Therapy|compound|START_ENTITY Recovery|nmod|Therapy Polymorphism|nmod|Recovery Polymorphism|compound|END_ENTITY	Influence of Androgen_Receptor CAG Polymorphism on Sexual Function Recovery after Testosterone Therapy in Late-Onset Hypogonadism .
26152357	0	Testosterone	21,33	Androgen_Receptor	70,87	Testosterone	Androgen Receptor	MESH:D013739	367	Chemical	Gene	START_ENTITY|nmod|Signaling Signaling|compound|END_ENTITY	Platelet-Synthesized Testosterone in Men with Prostate_Cancer Induces Androgen_Receptor Signaling .
23010313	0	Testosterone	0,12	BDNF	85,89	Testosterone	BDNF	MESH:D013739	12064(Tax:10090)	Chemical	Gene	has|nsubj|START_ENTITY has|dobj|effects effects|nmod|maturation maturation|acl|mediated mediated|nmod|END_ENTITY	Testosterone has sublayer-specific effects on dendritic spine maturation mediated by BDNF and PSD-95 in pyramidal neurons in the hippocampus CA1 area .
24565925	0	Testosterone	0,12	BDNF	98,102	Testosterone	BDNF	MESH:D013739	24225(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|advcl|END_ENTITY	Testosterone enhances functional recovery after stroke through promotion of antioxidant defenses , BDNF levels and neurogenesis in male rats .
24250491	0	Testosterone	68,80	CA1	86,89	Testosterone	CA1	MESH:D013739	310218(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|Region Region|compound|END_ENTITY	Microinjection of Dihydrotestosterone as a 5a-Reduced Metabolite of Testosterone into CA1 Region of Hippocampus Could Improve Spatial Learning in the Adult Male Rats .
16423876	0	Testosterone	0,12	FGF-2	23,28	Testosterone	FGF-2	MESH:D013739	14173(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Testosterone regulates FGF-2 expression during testis maturation by an IRES-dependent translational mechanism .
9047271	0	Testosterone	0,12	Fos	73,76	Testosterone	Fos	MESH:D013739	101831721	Chemical	Gene	influences|nsubj|START_ENTITY influences|dobj|expression expression|compound|END_ENTITY	Testosterone differentially influences sex-specific pheromone-stimulated Fos expression in limbic regions of Syrian_hamsters .
9571013	0	Testosterone	0,12	Fos	31,34	Testosterone	Fos	MESH:D013739	314322(Tax:10116)	Chemical	Gene	augments|nsubj|START_ENTITY augments|dobj|responses responses|compound|END_ENTITY	Testosterone augments neuronal Fos responses to estrous odors throughout the vomeronasal projection pathway of gonadectomized male and female rats .
25598450	0	Testosterone	13,25	Foxp3	110,115	Testosterone	Foxp3	MESH:D013739	50943	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of Testosterone on Inflammatory Response in Testicular Cells and Expression of Transcription Factor Foxp3 in T Cells .
25164816	0	Testosterone	0,12	GPRC6A	47,53	Testosterone	GPRC6A	MESH:D013739	222545	Chemical	Gene	Stimulates|compound|START_ENTITY Duox1|nsubj|Stimulates Duox1|nmod|END_ENTITY	Testosterone Stimulates Duox1 Activity through GPRC6A in Skin Keratinocytes .
26440882	0	Testosterone	39,51	GPRC6A	66,72	Testosterone	GPRC6A	MESH:D013739	210198(Tax:10090)	Chemical	Gene	Activation|compound|START_ENTITY Activation|nmod|END_ENTITY	Structural and Functional Evidence for Testosterone Activation of GPRC6A in Peripheral Tissues .
26752245	0	Testosterone	0,12	GnRH	81,85	Testosterone	GnRH	MESH:D013739	2796	Chemical	Gene	production|amod|START_ENTITY production|appos|challenge challenge|compound|END_ENTITY	Testosterone production in response to exogenous gonadotropin_releasing_hormone -LRB- GnRH challenge -RRB- depends on social environment and color polymorphism .
6232019	1	Testosterone	56,68	GnRH	115,119	Testosterone	GnRH	MESH:D013739	2796	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|suppression suppression|acl|induced induced|nmod|agonist agonist|compound|END_ENTITY	Testosterone enhances gonadotrophin suppression induced by GnRH agonist .
25791895	0	Testosterone	75,87	Gonadotropin-Releasing_Hormone	103,133	Testosterone	Gonadotropin-Releasing Hormone	MESH:D013739	2796	Chemical	Gene	Effects|compound|START_ENTITY Model|nmod|Effects Model|nmod|Leuprolide Leuprolide|compound|END_ENTITY	A Semi-Mechanistic Integrated Pharmacokinetic/Pharmacodynamic Model of the Testosterone Effects of the Gonadotropin-Releasing_Hormone Agonist Leuprolide in Prostate_Cancer Patients .
26622051	0	Testosterone	95,107	Insulin	0,7	Testosterone	Insulin	MESH:D013739	3630	Chemical	Gene	Replacement|compound|START_ENTITY Diabetes|nmod|Replacement Diabetes|nsubj|Resistance Resistance|compound|END_ENTITY	Insulin Resistance and Inflammation in Hypogonadotropic_Hypogonadism and Their Reduction After Testosterone Replacement in Men With Type 2 Diabetes .
6379494	0	Testosterone	0,12	LHRH	20,24	Testosterone	LHRH	MESH:D013739	25194(Tax:10116)	Chemical	Gene	raises|nsubj|START_ENTITY raises|dobj|levels levels|compound|END_ENTITY	Testosterone raises LHRH levels exclusively in the median eminence of castrated rats .
21273442	0	Testosterone	0,12	LRH-1	53,58	Testosterone	LRH-1	MESH:D013739	60349(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Testosterone , not 5a-dihydrotestosterone , stimulates LRH-1 leading to FSH-independent expression of Cyp19 and P450scc in granulosa cells .
1564558	2	Testosterone	291,303	ODC	357,360	Testosterone	ODC	MESH:D013739	24609(Tax:10116)	Chemical	Gene	implantation|amod|START_ENTITY elicited|nsubj|implantation elicited|dobj|increase increase|nmod|activity activity|compound|END_ENTITY	Testosterone implantation for 1 wk elicited a sixfold increase in ODC activity and a fourfold increase in ODC mRNA transcripts in the kidney .
21221202	0	Testosterone	22,34	Prostate-Specific_Antigen	39,64	Testosterone	Prostate-Specific Antigen	MESH:D013739	354	Chemical	Gene	START_ENTITY|nmod|Elevation Elevation|compound|END_ENTITY	Significance of Serum Testosterone for Prostate-Specific_Antigen -LRB- PSA -RRB- Elevation and Prediction of Prostate_Cancer in Patients with PSA Above 10 ng/ml .
25131184	0	Testosterone	78,90	Prostate-Specific_Antigen	20,45	Testosterone	Prostate-Specific Antigen	MESH:D013739	354	Chemical	Gene	Therapy|compound|START_ENTITY Response|nmod|Therapy Response|compound|END_ENTITY	Factors Influencing Prostate-Specific_Antigen Response among Men Treated with Testosterone Therapy for 6 Months .
26526966	0	Testosterone	0,12	Reelin	55,61	Testosterone	Reelin	MESH:D013739	19699(Tax:10090)	Chemical	Gene	Demethylation|compound|START_ENTITY Demethylation|nmod|Dinucleotides Dinucleotides|compound|END_ENTITY	Testosterone Depletion Induces Demethylation of Murine Reelin Promoter CpG Dinucleotides : A Preliminary Study .
1693130	0	Testosterone	0,12	TSH-beta	23,31	Testosterone	TSH-beta	MESH:D013739	22094(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|mRNA mRNA|amod|END_ENTITY	Testosterone increases TSH-beta mRNA , and modulates alpha-subunit mRNA differentially in mouse thyrotropic_tumor and castrate rat pituitary .
16855767	0	Testosterone	0,12	adiponectin	23,34	Testosterone	adiponectin	MESH:D013739	9370	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|levels levels|compound|END_ENTITY	Testosterone decreases adiponectin levels in female to male transsexuals .
11099831	0	Testosterone	0,12	amyloid_precursor_protein	40,65	Testosterone	amyloid precursor protein	MESH:D013739	54226(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|compound|END_ENTITY	Testosterone stimulates rapid secretory amyloid_precursor_protein release from rat hypothalamic cells via the activation of the mitogen-activated protein kinase pathway .
11226426	0	Testosterone	0,12	androgen_receptor	85,102	Testosterone	androgen receptor	MESH:D013739	11835(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|formation formation|acl|stimulated stimulated|nmod|END_ENTITY	Testosterone inhibits osteoclast formation stimulated by parathyroid_hormone through androgen_receptor .
1334007	0	Testosterone	0,12	androgen_receptor	75,92	Testosterone	androgen receptor	MESH:D013739	11835(Tax:10090)	Chemical	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	Testosterone and 5 alpha-dihydrotestosterone interact differently with the androgen_receptor to enhance transcription of the MMTV-CAT reporter gene .
15061970	0	Testosterone	1,13	androgen_receptor	28,45	Testosterone	androgen receptor	MESH:D013739	24208(Tax:10116)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	-LSB- Testosterone regulation of androgen_receptor protein expression in cultured vascular smooth muscle cells -RSB- .
16210377	0	Testosterone	0,12	androgen_receptor	91,108	Testosterone	androgen receptor	MESH:D013739	11835(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|parataxis|bypass bypass|nsubj|translocation translocation|nmod|complex complex|compound|END_ENTITY	Testosterone inhibits adipogenic differentiation in 3T3-L1 cells : nuclear translocation of androgen_receptor complex with beta-catenin and T-cell_factor_4 may bypass canonical Wnt signaling to down-regulate adipogenic transcription factors .
20479013	0	Testosterone	0,12	androgen_receptor	14,31	Testosterone	androgen receptor	MESH:D013739	367	Chemical	Gene	CAG|advmod|START_ENTITY CAG|nsubj|gene gene|compound|END_ENTITY	Testosterone , androgen_receptor gene CAG repeat length , mood and behaviour in adolescent males .
2298157	0	Testosterone	0,12	androgen_receptor	61,78	Testosterone	androgen receptor	MESH:D013739	367	Chemical	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Testosterone at high concentrations interacts with the human androgen_receptor similarly to dihydrotestosterone .
24994782	0	Testosterone	0,12	androgen_receptor	74,91	Testosterone	androgen receptor	MESH:D013739	24208(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Testosterone regulates keratin_33B expression in rat penis growth through androgen_receptor signaling .
25130462	0	Testosterone	0,12	androgen_receptor	33,50	Testosterone	androgen receptor	MESH:D013739	367	Chemical	Gene	treatment|amod|START_ENTITY increases|nsubj|treatment increases|dobj|expression expression|compound|END_ENTITY	Testosterone treatment increases androgen_receptor and aromatase gene expression in myotubes from patients with PCOS and controls , but does not induce insulin resistance .
8499343	0	Testosterone	0,12	androgen_receptor	42,59	Testosterone	androgen receptor	MESH:D013739	24208(Tax:10116)	Chemical	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|levels levels|nmod|mRNA mRNA|compound|END_ENTITY	Testosterone down-regulates the levels of androgen_receptor mRNA in smooth muscle cells from the rat corpora cavernosa via aromatization to estrogens .
12774311	0	Testosterone	0,12	aquaporin-4	26,37	Testosterone	aquaporin-4	MESH:D013739	361	Chemical	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|amod|END_ENTITY	Testosterone up-regulates aquaporin-4 expression in cultured astrocytes .
17537983	0	Testosterone	0,12	cystathionine_beta-synthase	33,60	Testosterone	cystathionine beta-synthase	MESH:D013739	875	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Testosterone regulation of renal cystathionine_beta-synthase : implications for sex-dependent differences in plasma homocysteine levels .
2502444	0	Testosterone	0,12	cytochrome_P-450	38,54	Testosterone	cytochrome P-450	MESH:D013739	25251(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|nmod|END_ENTITY	Testosterone metabolism by microsomal cytochrome_P-450 in liver of rats treated with some inducers .
6619140	0	Testosterone	0,12	cytochrome_P-450	27,43	Testosterone	cytochrome P-450	MESH:D013739	25251(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|RLM3 RLM3|amod|END_ENTITY	Testosterone metabolism by cytochrome_P-450 isozymes RLM3 and RLM5 and by microsomes .
24158761	0	Testosterone	0,12	erythropoietin	50,64	Testosterone	erythropoietin	MESH:D013739	2056	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|erythrocytosis erythrocytosis|nmod|END_ENTITY	Testosterone induces erythrocytosis via increased erythropoietin and suppressed hepcidin : evidence for a new erythropoietin/hemoglobin set point .
15745938	0	Testosterone	0,12	fibrinogen	39,49	Testosterone	fibrinogen	MESH:D013739	2244	Chemical	Gene	affect|nsubj|START_ENTITY affect|dobj|END_ENTITY	Testosterone does not adversely affect fibrinogen or tissue_plasminogen_activator -LRB- tPA -RRB- and plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- levels in 46 men with chronic_stable_angina .
15509729	0	Testosterone	0,12	follicle-stimulating_hormone_beta	24,57	Testosterone	follicle-stimulating hormone beta	MESH:D013739	25447(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|transcription transcription|amod|END_ENTITY	Testosterone stimulates follicle-stimulating_hormone_beta transcription via activation of extracellular_signal-regulated_kinase : evidence in rat pituitary cells .
7687506	0	Testosterone	0,12	galanin	23,30	Testosterone	galanin	MESH:D013739	29141(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Testosterone regulates galanin gene expression in the bed nucleus of the stria terminalis .
11330652	0	Testosterone	0,12	gonadotropin-releasing_hormone	90,120	Testosterone	gonadotropin-releasing hormone	MESH:D013739	14714(Tax:10090)	Chemical	Gene	effects|nsubj|START_ENTITY effects|advcl|luteinizing luteinizing|advcl|END_ENTITY	Testosterone effects on luteinizing hormone and follicle-stimulating hormone responses to gonadotropin-releasing_hormone in the mouse .
18407326	0	Testosterone	0,12	gonadotropin-releasing_hormone	34,64	Testosterone	gonadotropin-releasing hormone	MESH:D013739	2796	Chemical	Gene	surge|amod|START_ENTITY surge|dep|rationale rationale|nmod|blockers blockers|amod|END_ENTITY	Testosterone surge : rationale for gonadotropin-releasing_hormone blockers ?
22613708	0	Testosterone	0,12	gonadotropin-releasing_hormone	39,69	Testosterone	gonadotropin-releasing hormone	MESH:D013739	2796	Chemical	Gene	START_ENTITY|dobj|elevation elevation|nmod|challenge challenge|amod|END_ENTITY	Testosterone elevation and response to gonadotropin-releasing_hormone challenge by male northern cardinals -LRB- Cardinalis cardinalis -RRB- following aggressive behavior .
2497399	0	Testosterone	0,12	gonadotropin-releasing_hormone	130,160	Testosterone	gonadotropin-releasing hormone	MESH:D013739	25194(Tax:10116)	Chemical	Gene	START_ENTITY|ccomp|maintain maintain|nmod|antagonist antagonist|amod|END_ENTITY	Testosterone and dihydrotestosterone , but not estradiol , selectively maintain pituitary and serum follicle-stimulating hormone in gonadotropin-releasing_hormone antagonist treated male rats .
8636302	0	Testosterone	0,12	gonadotropin-releasing_hormone	77,107	Testosterone	gonadotropin-releasing hormone	MESH:D013739	2796	Chemical	Gene	treatment|amod|START_ENTITY alters|nsubj|treatment alters|nmod|patients patients|nmod|deficiency deficiency|amod|END_ENTITY	Testosterone treatment alters melatonin concentrations in male patients with gonadotropin-releasing_hormone deficiency .
15585557	0	Testosterone	0,12	growth_hormone	43,57	Testosterone	growth hormone	MESH:D013739	2688	Chemical	Gene	blunts|nsubj|START_ENTITY blunts|dobj|inhibition inhibition|nmod|secretion secretion|amod|END_ENTITY	Testosterone blunts feedback inhibition of growth_hormone secretion by experimentally elevated insulin-like growth factor-I concentrations .
2401714	0	Testosterone	0,12	growth_hormone	100,114	Testosterone	growth hormone	MESH:D013739	2688	Chemical	Gene	amplify|nsubj|START_ENTITY amplify|dobj|mass mass|nmod|duration duration|amod|END_ENTITY	Testosterone and oxandrolone , a nonaromatizable androgen , specifically amplify the mass and rate of growth_hormone -LRB- GH -RRB- secreted per burst without altering GH secretory burst duration or frequency or the GH half-life .
8188541	0	Testosterone	0,12	growth_hormone	104,118	Testosterone	growth hormone	MESH:D013739	2688	Chemical	Gene	feedback|amod|START_ENTITY feedback|acl|expressing expressing|dobj|gene gene|compound|END_ENTITY	Testosterone feedback on gonadotropin secretion and gene expression in transgenic_mice expressing human growth_hormone gene .
2871828	0	Testosterone	0,12	hCG	98,101	Testosterone	hCG	MESH:D013739	93659	Chemical	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Testosterone response of cryptorchid and hypophysectomized rats to human chorionic gonadotrophin -LRB- hCG -RRB- stimulation .
4033119	0	Testosterone	0,12	hCG	123,126	Testosterone	hCG	MESH:D013739	3342	Chemical	Gene	levels|amod|START_ENTITY seminal|nsubj|levels seminal|nmod|injection injection|compound|END_ENTITY	Testosterone and dihydrotestosterone levels in epididymis , vas_deferens , seminal vesicle and preputial gland of mice after hCG injection .
7040256	0	Testosterone	6,18	hCG	51,54	Testosterone	hCG	MESH:D013739	3342	Chemical	Gene	response|amod|START_ENTITY Serum|dobj|response Serum|nmod|injection injection|nmod|ovine-LH ovine-LH|compound|END_ENTITY	Serum Testosterone response to single injection of hCG ovine-LH and LHRH in male rats .
7690364	0	Testosterone	0,12	insulin-like_growth_factor-I	38,66	Testosterone	insulin-like growth factor-I	MESH:D013739	3479	Chemical	Gene	administration|amod|START_ENTITY increases|nsubj|administration increases|dobj|levels levels|amod|END_ENTITY	Testosterone administration increases insulin-like_growth_factor-I levels in normal men .
10098530	0	Testosterone	0,12	insulin-like_growth_factor-I_and_insulin-like_growth_factor-I-receptor	24,94	Testosterone	insulin-like growth factor-I and insulin-like growth factor-I-receptor	MESH:D013739	16001(Tax:10090)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Testosterone stimulates insulin-like_growth_factor-I_and_insulin-like_growth_factor-I-receptor gene expression in the mandibular condyle -- a model of endochondral ossification .
10859487	0	Testosterone	0,12	interleukin-6	83,96	Testosterone	interleukin-6	MESH:D013739	24498(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	Testosterone suppresses the response of the hypothalamic-pituitary-adrenal_axis to interleukin-6 .
24994782	0	Testosterone	0,12	keratin_33B	23,34	Testosterone	keratin 33B	MESH:D013739	450227(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Testosterone regulates keratin_33B expression in rat penis growth through androgen_receptor signaling .
25163025	0	Testosterone	0,12	klotho	40,46	Testosterone	klotho	MESH:D013739	83504(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Testosterone increases renal anti-aging klotho gene expression via the androgen_receptor-mediated pathway .
10853711	0	Testosterone	0,12	leptin	29,35	Testosterone	leptin	MESH:D013739	3952	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|concentrations concentrations|compound|END_ENTITY	Testosterone modulates serum leptin concentrations in a male patient with hypothalamic_hypogonadism .
12355336	0	Testosterone	0,12	leptin	40,46	Testosterone	leptin	MESH:D013739	3952	Chemical	Gene	rhythmicity|amod|START_ENTITY rhythmicity|nmod|receptor receptor|amod|END_ENTITY	Testosterone and diurnal rhythmicity of leptin , TNF-alpha and TNF-II receptor in insulin-resistant myotonic_dystrophy patients .
16150461	0	Testosterone	0,12	leptin	75,81	Testosterone	leptin	MESH:D013739	25608(Tax:10116)	Chemical	Gene	supplementation|compound|START_ENTITY supplementation|dep|Effects Effects|nmod|levels levels|compound|END_ENTITY	Testosterone and zinc supplementation in castrated rats : Effects on plasma leptin levels and relation with LH , FSH and testosterone .
9253326	0	Testosterone	0,12	leptin	52,58	Testosterone	leptin	MESH:D013739	3952	Chemical	Gene	normalizes|amod|START_ENTITY elevated|nsubj|normalizes elevated|dobj|levels levels|compound|END_ENTITY	Testosterone substitution normalizes elevated serum leptin levels in hypogonadal men .
23470307	0	Testosterone	0,12	mTOR	29,33	Testosterone	mTOR	MESH:D013739	21977(Tax:10090)	Chemical	Gene	signals|nsubj|START_ENTITY signals|nmod|END_ENTITY	Testosterone signals through mTOR and androgen_receptor to induce muscle_hypertrophy .
17636177	0	Testosterone	0,12	matrix_metalloproteinase-1	22,48	Testosterone	matrix metalloproteinase-1	MESH:D013739	4312	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Testosterone inhibits matrix_metalloproteinase-1 production in human endometrial stromal cells in vitro .
18548256	0	Testosterone	0,12	myoglobin	24,33	Testosterone	myoglobin	MESH:D013739	17189(Tax:10090)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	Testosterone stimulates myoglobin expression in different muscles of the mouse .
15539552	0	Testosterone	0,12	ornithine_aminotransferase	28,54	Testosterone	ornithine aminotransferase	MESH:D013739	18242(Tax:10090)	Chemical	Gene	down-regulates|amod|START_ENTITY END_ENTITY|nsubj|down-regulates	Testosterone down-regulates ornithine_aminotransferase gene and up-regulates arginase II and ornithine_decarboxylase genes for polyamines synthesis in the murine kidney .
2293029	0	Testosterone	0,12	ornithine_decarboxylase	23,46	Testosterone	ornithine decarboxylase	MESH:D013739	24609(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|levels levels|amod|END_ENTITY	Testosterone decreases ornithine_decarboxylase messenger RNA levels in primary cultures of rat Sertoli cells .
2840265	0	Testosterone	0,12	ornithine_decarboxylase	28,51	Testosterone	ornithine decarboxylase	MESH:D013739	24609(Tax:10116)	Chemical	Gene	suppression|amod|START_ENTITY suppression|nmod|activity activity|amod|END_ENTITY	Testosterone suppression of ornithine_decarboxylase activity in rat Sertoli cells .
15523591	0	Testosterone	0,12	osteoprotegerin	23,38	Testosterone	osteoprotegerin	MESH:D013739	18383(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Testosterone increases osteoprotegerin mRNA expression in mouse osteoblast cells .
11226426	0	Testosterone	0,12	parathyroid_hormone	57,76	Testosterone	parathyroid hormone	MESH:D013739	19226(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|formation formation|acl|stimulated stimulated|nmod|END_ENTITY	Testosterone inhibits osteoclast formation stimulated by parathyroid_hormone through androgen_receptor .
19947175	0	Testosterone	0,12	peroxisome_proliferator-activated_receptor_gamma	38,86	Testosterone	peroxisome proliferator-activated receptor gamma	MESH:D013739	5468	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	Testosterone inhibits the activity of peroxisome_proliferator-activated_receptor_gamma in a transcriptional transaction assay .
21693622	0	Testosterone	0,12	phospholipase_D	24,39	Testosterone	phospholipase D	MESH:D013739	2822	Chemical	Gene	suppresses|amod|START_ENTITY END_ENTITY|nsubj|suppresses	Testosterone suppresses phospholipase_D , causing sex differences in leukotriene biosynthesis in human monocytes .
2004607	0	Testosterone	0,12	pro-opiomelanocortin	23,43	Testosterone	pro-opiomelanocortin	MESH:D013739	5443	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Testosterone regulates pro-opiomelanocortin gene expression in the primate brain .
2267955	0	Testosterone	0,12	prolactin	32,41	Testosterone	prolactin	MESH:D013739	24683(Tax:10116)	Chemical	Gene	elevates|nsubj|START_ENTITY elevates|dobj|content content|compound|END_ENTITY	Testosterone elevates pituitary prolactin content of long-term castrated rats under constant but not under periodic light .
11421528	0	Testosterone	0,12	prostate-specific_antigen	43,68	Testosterone	prostate-specific antigen	MESH:D013739	354	Chemical	Gene	treatment|amod|START_ENTITY treatment|dep|level level|amod|END_ENTITY	Testosterone treatment in hypogonadal men : prostate-specific_antigen level and risk of prostate_cancer .
7721656	0	Testosterone	0,12	proto-oncogene_c-myc	27,47	Testosterone	proto-oncogene c-myc	MESH:D013739	24577(Tax:10116)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Testosterone regulation of proto-oncogene_c-myc expression in primary Sertoli cell cultures from prepubertal rats .
22405892	0	Testosterone	0,12	seladin-1	26,35	Testosterone	seladin-1	MESH:D013739	74754(Tax:10090)	Chemical	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|amod|END_ENTITY	Testosterone up-regulates seladin-1 expression by iAR and PI3-K/Akt signaling pathway in C6 cells .
2874533	0	Testosterone	0,12	tyrosine_hydroxylase	27,47	Testosterone	tyrosine hydroxylase	MESH:D013739	25085(Tax:10116)	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|expression expression|amod|END_ENTITY	Testosterone inhibition of tyrosine_hydroxylase expression in the hypothalamic arcuate nucleus .
11904449	0	Testosterone	0,12	vascular_cell_adhesion_molecule-1	38,71	Testosterone	vascular cell adhesion molecule-1	MESH:D013739	7412	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|nmod|cells cells|amod|END_ENTITY	Testosterone attenuates expression of vascular_cell_adhesion_molecule-1 by conversion to estradiol by aromatase in endothelial cells : implications in atherosclerosis .
12387879	0	Testosterone	0,12	vascular_cell_adhesion_molecule-1	58,91	Testosterone	vascular cell adhesion molecule-1	MESH:D013739	7412	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Testosterone inhibits tumor_necrosis_factor-alpha-induced vascular_cell_adhesion_molecule-1 expression in human aortic endothelial cells .
7920892	0	Testosterone	0,12	vasopressin	31,42	Testosterone	vasopressin	MESH:D013739	551	Chemical	Gene	normalizes|nsubj|START_ENTITY normalizes|dobj|response response|compound|END_ENTITY	Testosterone normalizes plasma vasopressin response to osmotic stimuli in men with hypogonadism .
15329416	0	Tetra-O-methyl_nordihydroguaiaretic_acid	0,40	Cdc2	100,104	Tetra-O-methyl nordihydroguaiaretic acid	Cdc2	MESH:C076852	983	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|inhibiting inhibiting|dobj|END_ENTITY	Tetra-O-methyl_nordihydroguaiaretic_acid induces growth_arrest and cellular apoptosis by inhibiting Cdc2 and survivin expression .
21138578	0	Tetra-O-methyl_nordihydroguaiaretic_acid	0,40	TNF-a	102,107	Tetra-O-methyl nordihydroguaiaretic acid	TNF-a	MESH:C076852	21926(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|transcription transcription|nmod|END_ENTITY	Tetra-O-methyl_nordihydroguaiaretic_acid -LRB- Terameprocol -RRB- inhibits the NF-kB-dependent transcription of TNF-a and MCP-1 / CCL2 genes by preventing RelA from binding its cognate sites on DNA .
10914635	0	Tetracaine	0,10	insulin	22,29	Tetracaine	insulin	MESH:D013748	3630	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|compound|END_ENTITY	Tetracaine stimulates insulin secretion through the mobilization of Ca2 + from thapsigargin - and IP3-insensitive Ca2 + reservoir in pancreatic beta-cells .
9200568	0	Tetracaine	0,10	insulin	53,60	Tetracaine	insulin	MESH:D013748	3630	Chemical	Gene	+|amod|START_ENTITY +|dep|release release|compound|END_ENTITY	Tetracaine stimulates extracellular Ca2 + - independent insulin release .
26901245	0	Tetrachlorobenzoquinone	0,23	IL-1b	110,115	Tetrachlorobenzoquinone	IL-1b	MESH:C000591600	3553	Chemical	Gene	Activation|compound|START_ENTITY Activation|nmod|END_ENTITY	Tetrachlorobenzoquinone Stimulates NLRP3 Inflammasome-Mediated Post-Translational Activation and Secretion of IL-1b in the HUVEC Endothelial Cell Line .
26901245	0	Tetrachlorobenzoquinone	0,23	NLRP3	35,40	Tetrachlorobenzoquinone	NLRP3	MESH:C000591600	114548	Chemical	Gene	Activation|compound|START_ENTITY Activation|compound|END_ENTITY	Tetrachlorobenzoquinone Stimulates NLRP3 Inflammasome-Mediated Post-Translational Activation and Secretion of IL-1b in the HUVEC Endothelial Cell Line .
10092766	0	Tetracycline	0,12	COX-2	26,31	Tetracycline	COX-2	MESH:D013752	17709(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|expression expression|compound|END_ENTITY	Tetracycline up-regulates COX-2 expression and prostaglandin_E2 production independent of its effect on nitric_oxide .
18341570	0	Tetracycline	0,12	CXCL8	44,49	Tetracycline	CXCL8	MESH:D013752	3576	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	Tetracycline suppresses ATP gamma S-induced CXCL8 and CXCL1 production by the human dermal microvascular endothelial cell-1 -LRB- HMEC-1 -RRB- cell line and primary human dermal microvascular endothelial cells .
9296393	0	Tetracycline	0,12	vimentin	37,45	Tetracycline	vimentin	MESH:D013752	22352(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Tetracycline regulated expression of vimentin in fibroblasts derived from vimentin null mice .
9296393	0	Tetracycline	0,12	vimentin	74,82	Tetracycline	vimentin	MESH:D013752	22352(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY derived|nsubj|expression derived|nmod|mice mice|amod|END_ENTITY	Tetracycline regulated expression of vimentin in fibroblasts derived from vimentin null mice .
15670752	0	Tetradecanoyl_phorbol_acetate	0,29	Toll-like_receptor_2	52,72	Tetradecanoyl phorbol acetate	Toll-like receptor 2	MESH:D013755	7097	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Tetradecanoyl_phorbol_acetate induces expression of Toll-like_receptor_2 in U937 cells : involvement of PKC , ERK , and NF-kappaB .
18843091	0	Tetradecylthioacetic_acid	0,25	cyclooxygenase_2	40,56	Tetradecylthioacetic acid	cyclooxygenase 2	MESH:C062078	29527(Tax:10116)	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	Tetradecylthioacetic_acid downregulates cyclooxygenase_2 in the renal cortex of two-kidney , one-clip hypertensive rats .
2123338	0	Tetraethylammonium	0,18	CA2	46,49	Tetraethylammonium	CA2	MESH:D019789	54231(Tax:10116)	Chemical	Gene	sensitivity|amod|START_ENTITY sensitivity|nmod|END_ENTITY	Tetraethylammonium ion sensitivity of a 35-pS CA2 -LRB- + -RRB- - activated K + channel in GH3 cells that is activated by thyrotropin-releasing_hormone .
8303682	0	Tetrafibricin	0,13	fibrinogen	29,39	Tetrafibricin	fibrinogen	MESH:C082780	2244	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Tetrafibricin : a nonpeptidic fibrinogen receptor inhibitor from Streptomyces neyagawaensis -LRB- I -RRB- .
8360097	0	Tetrafibricin	0,13	fibrinogen	23,33	Tetrafibricin	fibrinogen	MESH:C082780	2244	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Tetrafibricin , a novel fibrinogen receptor antagonist .
25050159	0	Tetrahydro-b-carboline	43,65	sstr3	66,71	Tetrahydro-b-carboline	sstr3	null	481272(Tax:9615)	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|amod|END_ENTITY	Investigation of Cardiovascular Effects of Tetrahydro-b-carboline sstr3 antagonists .
2616041	0	Tetrahydroaminoacridine	0,23	monoamine_oxidase	53,70	Tetrahydroaminoacridine	monoamine oxidase	MESH:D013619	29253(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Tetrahydroaminoacridine inhibits human and rat brain monoamine_oxidase .
9383205	0	Tetrahydrobiopterin	0,19	EGF_and_NGF	72,83	Tetrahydrobiopterin	EGF and NGF	MESH:C003402	25313;310738	Chemical	Gene	induced|nsubj|START_ENTITY induced|nmod|END_ENTITY	Tetrahydrobiopterin as a mediator of PC12 cell proliferation induced by EGF_and_NGF .
9405225	0	Tetrahydrobiopterin	0,19	cyclooxygenase-2	30,46	Tetrahydrobiopterin	cyclooxygenase-2	MESH:C003402	5743	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	Tetrahydrobiopterin modulates cyclooxygenase-2 expression in human mesangial cells .
9268712	0	Tetrahydrobiopterin	0,19	nitric_oxide_synthase	96,117	Tetrahydrobiopterin	nitric oxide synthase	MESH:C003402	4846	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Tetrahydrobiopterin regulates superoxide and nitric_oxide generation by recombinant endothelial nitric_oxide_synthase .
15556637	0	Tetrahydrobiopterin	0,19	phenylalanine_hydroxylase	29,54	Tetrahydrobiopterin	phenylalanine hydroxylase	MESH:C003402	5053	Chemical	Gene	protects|nsubj|START_ENTITY protects|dobj|activity activity|amod|END_ENTITY	Tetrahydrobiopterin protects phenylalanine_hydroxylase activity in vivo : implications for tetrahydrobiopterin-responsive hyperphenylalaninemia .
23559577	0	Tetrahydrobiopterin	0,19	phenylalanine_hydroxylase	43,68	Tetrahydrobiopterin	phenylalanine hydroxylase	MESH:C003402	5053	Chemical	Gene	START_ENTITY|appos|mode mode|nmod|action action|nmod|END_ENTITY	Tetrahydrobiopterin , its mode of action on phenylalanine_hydroxylase , and importance of genotypes for pharmacological therapy of phenylketonuria .
14500751	0	Tetrahydrobiopterin	0,19	tyrosine_hydroxylase	42,62	Tetrahydrobiopterin	tyrosine hydroxylase	MESH:C003402	7054	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|dobj|nitration nitration|nmod|END_ENTITY	Tetrahydrobiopterin prevents nitration of tyrosine_hydroxylase by peroxynitrite and nitrogen_dioxide .
18419768	0	Tetrahydrobiopterin	0,19	tyrosine_hydroxylase	49,69	Tetrahydrobiopterin	tyrosine hydroxylase	MESH:C003402	7054	Chemical	Gene	shows|nsubj|START_ENTITY shows|dobj|activity activity|nmod|END_ENTITY	Tetrahydrobiopterin shows chaperone activity for tyrosine_hydroxylase .
21265541	0	Tetrahydrofolic_Acid	0,20	tyrosinase	63,73	Tetrahydrofolic Acid	tyrosinase	MESH:C030371	7299	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Tetrahydrofolic_Acid is a potent suicide substrate of mushroom tyrosinase .
18087590	0	Tetrahydrofurandiol	0,19	phospholipase_A2	35,51	Tetrahydrofurandiol	phospholipase A2	null	151056	Chemical	Gene	stimulation|amod|START_ENTITY stimulation|nmod|END_ENTITY	Tetrahydrofurandiol stimulation of phospholipase_A2 , lipoxygenase , and cyclooxygenase gene expression and MCF-7 human breast_cancer cell proliferation .
18235987	0	Tetrahydrofurobenzofuran_cymserine	0,34	butyrylcholinesterase	45,66	Tetrahydrofurobenzofuran cymserine	butyrylcholinesterase	MESH:C531991	590	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Tetrahydrofurobenzofuran_cymserine , a potent butyrylcholinesterase inhibitor and experimental Alzheimer drug candidate , enzyme kinetic analysis .
20188553	0	Tetrahydroindolizinone	0,22	NK1	23,26	Tetrahydroindolizinone	NK1	null	6869	Chemical	Gene	START_ENTITY|dobj|antagonists antagonists|nummod|END_ENTITY	Tetrahydroindolizinone NK1 antagonists .
17005393	0	Tetrahydroisoquinoline	0,22	PPARgamma	23,32	Tetrahydroisoquinoline	PPARgamma	null	5468	Chemical	Gene	agonists|compound|START_ENTITY agonists|compound|END_ENTITY	Tetrahydroisoquinoline PPARgamma agonists : design of novel , highly selective non-TZD antihyperglycemic agents .
25450677	0	Tetrahydropalmatine	0,19	p38MAPK	76,83	Tetrahydropalmatine	p38MAPK	MESH:C014215	26416(Tax:10090)	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|activation activation|nmod|END_ENTITY	Tetrahydropalmatine promotes myoblast differentiation through activation of p38MAPK and MyoD .
9572583	0	Tetrahydropapaveroline	0,22	dopamine_transporter	75,95	Tetrahydropapaveroline	dopamine transporter	MESH:D013765	6531	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|nmod|END_ENTITY	Tetrahydropapaveroline and its derivatives inhibit dopamine uptake through dopamine_transporter expressed in HEK293 cells .
26259804	0	Tetrahydropyrrolo-diazepenones	0,30	ERK2	48,52	Tetrahydropyrrolo-diazepenones	ERK2	null	5594	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Tetrahydropyrrolo-diazepenones as inhibitors of ERK2 kinase .
21115247	0	Tetrahydroquinoline	0,19	glucocorticoid_receptor	20,43	Tetrahydroquinoline	glucocorticoid receptor	MESH:C542964	2908	Chemical	Gene	agonists|amod|START_ENTITY agonists|compound|END_ENTITY	Tetrahydroquinoline glucocorticoid_receptor agonists : discovery of a 3-hydroxyl for improving receptor selectivity .
22616006	0	Tetrahydrouridine	0,17	cytidine_deaminase	90,108	Tetrahydrouridine	cytidine deaminase	MESH:D013767	978	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|regulation regulation|advmod|regardless regardless|nmod|levels levels|amod|END_ENTITY	Tetrahydrouridine inhibits cell proliferation through cell cycle regulation regardless of cytidine_deaminase expression levels .
24672948	0	Tetramethyl_pyrazine	11,31	IL-1beta	51,59	Tetramethyl pyrazine	IL-1beta	MESH:C017953	24494(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|levels levels|nmod|END_ENTITY	-LSB- Effect of Tetramethyl_pyrazine on serum levels of IL-1beta , IL-6 , and IL-2 , and NO and PGE2 in the synovial fluid of CIA rats : an experimental research -RSB- .
26019625	0	Tetramethylpyrazine	0,19	CTGF	29,33	Tetramethylpyrazine	CTGF	MESH:C017953	1490	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Tetramethylpyrazine inhibits CTGF and Smad2/3 expression and proliferation of hepatic stellate cells .
25237906	0	Tetramethylpyrazine	0,19	Connexin32	76,86	Tetramethylpyrazine	Connexin32	MESH:C017953	2705	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Tetramethylpyrazine Suppresses Transient Oxygen-Glucose Deprivation-Induced Connexin32 Expression and Cell Apoptosis via the ERK1/2 and p38 MAPK Pathway in Cultured Hippocampal Neurons .
25237906	0	Tetramethylpyrazine	0,19	ERK1/2	125,131	Tetramethylpyrazine	ERK1/2	MESH:C017953	5595;5594	Chemical	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	Tetramethylpyrazine Suppresses Transient Oxygen-Glucose Deprivation-Induced Connexin32 Expression and Cell Apoptosis via the ERK1/2 and p38 MAPK Pathway in Cultured Hippocampal Neurons .
17302993	0	Tetramethylpyrazine	0,19	HIF-1alpha	31,41	Tetramethylpyrazine	HIF-1alpha	MESH:C017953	29560(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	Tetramethylpyrazine suppresses HIF-1alpha , TNF-alpha , and activated caspase-3 expression in middle_cerebral_artery_occlusion-induced brain_ischemia in rats .
23830368	0	Tetramethylpyrazine	0,19	aquaporin_8	36,47	Tetramethylpyrazine	aquaporin 8	MESH:C017953	29172(Tax:10116)	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Tetramethylpyrazine upregulates the aquaporin_8 expression of hepatocellular mitochondria in septic rats .
16173946	0	Tetramethylpyrazine	0,19	endothelin-1	57,69	Tetramethylpyrazine	endothelin-1	MESH:C017953	1906	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	Tetramethylpyrazine downregulates angiotensin II-induced endothelin-1 gene expression in vascular endothelial cells .
9595468	0	Tetramethylpyrazine	0,19	endothelin-1	73,85	Tetramethylpyrazine	endothelin-1	MESH:C017953	100009270(Tax:9986)	Chemical	Gene	blocks|nsubj|START_ENTITY blocks|advcl|END_ENTITY	Tetramethylpyrazine , a Chinese drug , blocks coronary vasoconstriction by endothelin-1 and decreases plasma endothelin-1 levels in experimental animals .
16847723	0	Tetramethylpyrazine	0,19	heme_oxygenase-1	28,44	Tetramethylpyrazine	heme oxygenase-1	MESH:C017953	24451(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Tetramethylpyrazine induces heme_oxygenase-1 expression and attenuates myocardial_ischemia / reperfusion injury in rats .
23726836	0	Tetramethylpyrazine	0,19	iNOS	45,49	Tetramethylpyrazine	iNOS	MESH:C017953	4843	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|compound|END_ENTITY	Tetramethylpyrazine attenuates TNF-a-induced iNOS expression in human endothelial cells : Involvement of Syk-mediated activation of PI3K-IKK-IkB signaling pathways .
19540326	0	Tetramethylpyrazine	0,19	interleukin-8	31,44	Tetramethylpyrazine	interleukin-8	MESH:C017953	3576	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Tetramethylpyrazine suppresses interleukin-8 expression in LPS-stimulated human umbilical vein endothelial cell by blocking ERK , p38 and nulear factor-kappaB signaling pathways .
26983576	0	Tetrandrine	0,11	Gli-1	91,96	Tetrandrine	Gli-1	MESH:C009438	2735	Chemical	Gene	reverses|nsubj|START_ENTITY reverses|nmod|END_ENTITY	Tetrandrine reverses epithelial-mesenchymal transition in bladder_cancer by downregulating Gli-1 .
12508373	0	Tetrandrine	11,22	ICAM-1	34,40	Tetrandrine	ICAM-1	MESH:C009438	25464(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of Tetrandrine and QYT on ICAM-1 and SOD gene expression in pancreas and liver of rats with acute pancreatitis .
3572257	0	Tetranitromethane	0,17	high_density_lipoprotein	40,64	Tetranitromethane	high density lipoprotein	MESH:D013774	53369	Chemical	Gene	modification|amod|START_ENTITY modification|nmod|END_ENTITY	Tetranitromethane modification of human high_density_lipoprotein -LRB- HDL3 -RRB- : inactivation of high_density_lipoprotein binding is not related to cross-linking of phospholipids to apoproteins .
14745171	0	Tetrapetalone_A	0,15	lipoxygenase	25,37	Tetrapetalone A	lipoxygenase	MESH:C492598	547836(Tax:3847)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Tetrapetalone_A , a novel lipoxygenase inhibitor from Streptomyces sp .
23302890	0	Tetraspanin	0,11	CD151	12,17	Tetraspanin	CD151	null	977	Chemical	Gene	mediates|compound|START_ENTITY mediates|compound|END_ENTITY	Tetraspanin CD151 mediates papillomavirus type_16 endocytosis .
25955299	0	Tetraspanin	0,11	CD82	27,31	Tetraspanin	CD82	null	3732	Chemical	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	Tetraspanin Family Member , CD82 , Regulates Expression of EZH2 via Inactivation of p38 MAPK Signaling in Leukemia Cells .
25955299	0	Tetraspanin	0,11	EZH2	57,61	Tetraspanin	EZH2	null	2146	Chemical	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	Tetraspanin Family Member , CD82 , Regulates Expression of EZH2 via Inactivation of p38 MAPK Signaling in Leukemia Cells .
26252619	0	Tetrathionate	13,26	Thioredoxin_Reductase	40,61	Tetrathionate	Thioredoxin Reductase	CHEBI:16094	25824	Chemical	Gene	Reduction|nmod|START_ENTITY Reduction|nmod|END_ENTITY	Reduction of Tetrathionate by Mammalian Thioredoxin_Reductase .
7458956	0	Tetrodotoxin	0,12	glutamate_decarboxylase	63,86	Tetrodotoxin	glutamate decarboxylase	MESH:D013779	2752	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	Tetrodotoxin inhibition in vitro of protoveratrine A-activated glutamate_decarboxylase in synaptosomes .
16867261	0	Th2	37,40	Th1	30,33	Th2	Th1	null	51497	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nmod|END_ENTITY	Curcumin regulated shift from Th1 to Th2 in trinitrobenzene_sulphonic_acid-induced chronic_colitis .
8655287	0	Thalidomide	0,11	IL-2	39,43	Thalidomide	IL-2	MESH:D013792	3558	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|synthesis synthesis|nmod|END_ENTITY	Thalidomide increases the synthesis of IL-2 in cultures of human mononuclear cells stimulated with Concanavalin-A , Staphylococcal enterotoxin A , and purified protein derivative .
16837501	0	Thalidomide	0,11	IL-8	27,31	Thalidomide	IL-8	MESH:D013792	3576	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|release release|compound|END_ENTITY	Thalidomide reduces IL-18 , IL-8 and TNF-alpha release from alveolar macrophages in interstitial_lung_disease .
11884428	0	Thalidomide	0,11	NF-kappa_B	23,33	Thalidomide	NF-kappa B	MESH:D013792	4790	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|activation activation|amod|END_ENTITY	Thalidomide suppresses NF-kappa_B activation induced by TNF and H2O2 , but not that activated by ceramide , lipopolysaccharides , or phorbol_ester .
12485902	0	Thalidomide	0,11	NFkappaB	53,61	Thalidomide	NFkappaB	MESH:D013792	4790	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	Thalidomide suppresses the interleukin_1beta-induced NFkappaB signaling pathway in colon_cancer cells .
16136308	0	Thalidomide	0,11	P-glycoprotein	35,49	Thalidomide	P-glycoprotein	MESH:D013792	5243	Chemical	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	Thalidomide does not interact with P-glycoprotein .
21792375	0	Thalidomide	0,11	TNF-a	71,76	Thalidomide	TNF-a	MESH:D013792	7124	Chemical	Gene	Synthesis|compound|START_ENTITY Synthesis|nmod|END_ENTITY	Thalidomide Analogues Suppress Lipopolysaccharide-Induced Synthesis of TNF-a and Nitrite , an Intermediate of Nitric_Oxide , in a Cellular Model of Inflammation .
12200397	1	Thalidomide	154,165	TNF-alpha	328,337	Thalidomide	TNF-alpha	MESH:D013792	7124	Chemical	Gene	drug|nsubj|START_ENTITY drug|acl:relcl|found found|xcomp|inhibit inhibit|dobj|production production|nmod|tumor_necrosis_factor-alpha tumor_necrosis_factor-alpha|appos|END_ENTITY	Thalidomide -LRB- Thal -RRB- is a drug with antiangiogenic , anti-inflammatory , and immunomodulatory properties that was found to inhibit the production of tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- in vitro .
12296856	0	Thalidomide	0,11	TNF-alpha	68,77	Thalidomide	TNF-alpha	MESH:D013792	7124	Chemical	Gene	have|nsubj|START_ENTITY have|dobj|effects effects|nmod|END_ENTITY	Thalidomide and its analogues have distinct and opposing effects on TNF-alpha and TNFR2 during co-stimulation of both CD4 -LRB- + -RRB- and CD8 -LRB- + -RRB- T cells .
17268092	0	Thalidomide	0,11	TNF-alpha	77,86	Thalidomide	TNF-alpha	MESH:D013792	7124	Chemical	Gene	analogs|amod|START_ENTITY analogs|dep|Synthesis Synthesis|nmod|inhibitors inhibitors|nmod|production production|amod|END_ENTITY	Thalidomide analogs from diamines : Synthesis and evaluation as inhibitors of TNF-alpha production .
18668392	0	Thalidomide	0,11	TNF-alpha	48,57	Thalidomide	TNF-alpha	MESH:D013792	7124	Chemical	Gene	suppressed|nsubj|START_ENTITY suppressed|advcl|enhancing enhancing|dobj|END_ENTITY	Thalidomide suppressed IL-1beta while enhancing TNF-alpha and IL-10 , when cells in whole blood were stimulated with lipopolysaccharide .
8683039	0	Thalidomide	0,11	TNF-alpha	79,88	Thalidomide	TNF-alpha	MESH:D013792	7124	Chemical	Gene	agonistic|nsubj|START_ENTITY agonistic|xcomp|LPS LPS|dobj|synthesis synthesis|nmod|END_ENTITY	Thalidomide can be either agonistic or antagonistic to LPS evoked synthesis of TNF-alpha by mononuclear cells .
9657054	0	Thalidomide	0,11	TNF-alpha	65,74	Thalidomide	TNF-alpha	MESH:D013792	21926(Tax:10090)	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|release release|nmod|tumor_necrosis_factor-alpha tumor_necrosis_factor-alpha|appos|END_ENTITY	Thalidomide promotes the release of tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- and lethality by lipopolysaccharide in mice .
26692341	0	Thalidomide	0,11	Tumor_necrosis_factor-alpha	23,50	Thalidomide	Tumor necrosis factor-alpha	MESH:D013792	7124	Chemical	Gene	analogues|amod|START_ENTITY analogues|dep|inhibitors inhibitors|amod|END_ENTITY	Thalidomide analogues : Tumor_necrosis_factor-alpha inhibitors and their evaluation as anti-inflammatory agents .
12894531	0	Thalidomide	0,11	VEGF	45,49	Thalidomide	VEGF	MESH:D013792	7422	Chemical	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|nmod|END_ENTITY	Thalidomide down-regulates the expression of VEGF and bFGF in cisplatin-resistant human lung_carcinoma cells .
18469028	0	Thalidomide	0,11	VEGF	26,30	Thalidomide	VEGF	MESH:D013792	7422	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|levels levels|compound|END_ENTITY	Thalidomide reduces serum VEGF levels and improves peripheral_neuropathy in POEMS_syndrome .
19843943	0	Thalidomide	0,11	caspase-1	35,44	Thalidomide	caspase-1	MESH:D013792	12362(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	Thalidomide inhibits activation of caspase-1 .
24460184	0	Thalidomide	0,11	pregnane_X_receptor	91,110	Thalidomide	pregnane X receptor	MESH:D013792	8856	Chemical	Gene	increases|nsubj|START_ENTITY increases|nmod|activation activation|nmod|END_ENTITY	Thalidomide increases human hepatic cytochrome P450 3A enzymes by direct activation of the pregnane_X_receptor .
22977536	0	Thalidomide	0,11	substance_P	58,69	Thalidomide	substance P	MESH:D013792	6863	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|compound|END_ENTITY	Thalidomide and irradiation combination therapy increases substance_P levels in vitro .
14708607	0	Thalidomide	0,11	tumor_necrosis_factor-alpha	21,48	Thalidomide	tumor necrosis factor-alpha	MESH:D013792	21926(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Thalidomide inhibits tumor_necrosis_factor-alpha production and antigen presentation by Langerhans cells .
16943688	0	Thalidomide	0,11	tumor_necrosis_factor-alpha	48,75	Thalidomide	tumor necrosis factor-alpha	MESH:D013792	24835(Tax:10116)	Chemical	Gene	START_ENTITY|dep|blockade blockade|nmod|END_ENTITY	Thalidomide in rat liver_cirrhosis : blockade of tumor_necrosis_factor-alpha via inhibition of degradation of an inhibitor of nuclear factor-kappaB .
17964176	0	Thalidomide	0,11	tumor_necrosis_factor-alpha	66,93	Thalidomide	tumor necrosis factor-alpha	MESH:D013792	24835(Tax:10116)	Chemical	Gene	inhibition|amod|START_ENTITY perturbed|nsubj|inhibition perturbed|dobj|END_ENTITY	Thalidomide inhibition of perturbed vasculature and glial-derived tumor_necrosis_factor-alpha in an animal model of inflamed Alzheimer 's _ disease brain .
17964516	0	Thalidomide	0,11	tumor_necrosis_factor-alpha	45,72	Thalidomide	tumor necrosis factor-alpha	MESH:D013792	7124	Chemical	Gene	suppressed|nsubj|START_ENTITY suppressed|xcomp|END_ENTITY	Thalidomide suppressed interleukin-6 but not tumor_necrosis_factor-alpha in volunteers with experimental endotoxemia .
7561198	0	Thalidomide	0,11	tumor_necrosis_factor-alpha	21,48	Thalidomide	tumor necrosis factor-alpha	MESH:D013792	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Thalidomide inhibits tumor_necrosis_factor-alpha production by lipopolysaccharide - and lipoarabinomannan-stimulated human microglial cells .
9657054	0	Thalidomide	0,11	tumor_necrosis_factor-alpha	36,63	Thalidomide	tumor necrosis factor-alpha	MESH:D013792	21926(Tax:10090)	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|release release|nmod|END_ENTITY	Thalidomide promotes the release of tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- and lethality by lipopolysaccharide in mice .
8496685	0	Thalidomide	0,11	tumor_necrosis_factor_alpha	44,71	Thalidomide	tumor necrosis factor alpha	MESH:D013792	7124	Chemical	Gene	exerts|nsubj|START_ENTITY exerts|nmod|END_ENTITY	Thalidomide exerts its inhibitory action on tumor_necrosis_factor_alpha by enhancing mRNA degradation .
8521296	0	Thalidomide	0,11	tumor_necrosis_factor_alpha	30,57	Thalidomide	tumor necrosis factor alpha	MESH:D013792	7124	Chemical	Gene	treatment|amod|START_ENTITY reduces|nsubj|treatment reduces|dobj|production production|compound|END_ENTITY	Thalidomide treatment reduces tumor_necrosis_factor_alpha production and enhances weight_gain in patients with pulmonary_tuberculosis .
8675185	0	Thalidomide	0,11	tumor_necrosis_factor_alpha	21,48	Thalidomide	tumor necrosis factor alpha	MESH:D013792	24835(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Thalidomide inhibits tumor_necrosis_factor_alpha , decreases nitric_oxide synthesis , and ameliorates the hyperdynamic circulatory syndrome in portal-hypertensive rats .
7535889	0	Thallium	0,8	monoamine_oxidase	19,36	Thallium	monoamine oxidase	MESH:D013793	29253(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|activity activity|amod|END_ENTITY	Thallium increases monoamine_oxidase activity and serotonin turnover rate in rat brain regions .
17652336	0	Thapsigargin	0,12	TRAIL-R2	92,100	Thapsigargin	TRAIL-R2	MESH:D019284	8795	Chemical	Gene	sensitizes|nsubj|START_ENTITY sensitizes|nmod|up-regulation up-regulation|nmod|END_ENTITY	Thapsigargin sensitizes human melanoma cells to TRAIL-induced apoptosis by up-regulation of TRAIL-R2 through the unfolded protein response .
20713550	0	Thapsigargin	0,12	activating_transcription_factor_3	35,68	Thapsigargin	activating transcription factor 3	MESH:D019284	467	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Thapsigargin induces expression of activating_transcription_factor_3 in human keratinocytes involving Ca2 + ions and c-Jun_N-terminal_protein_kinase .
8485167	0	Thapsigargin	0,12	c-fos	76,81	Thapsigargin	c-fos	MESH:D019284	2353	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Thapsigargin , an inhibitor of endoplasmic reticulum Ca -LRB- 2 + -RRB- - ATPase , enhances c-fos expression but antagonizes vacuole formation of human hepatoma cells induced by teleocidin .
17720960	0	Theaflavins	0,11	AMPK	68,72	Theaflavins	AMPK	null	5563	Chemical	Gene	attenuate|nsubj|START_ENTITY attenuate|advcl|activating activating|dobj|END_ENTITY	Theaflavins attenuate hepatic lipid accumulation through activating AMPK in human HepG2 cells .
17182072	0	Theanaphthoquinone	0,18	fatty_acid_synthase	28,47	Theanaphthoquinone	fatty acid synthase	MESH:C503232	2194	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Theanaphthoquinone inhibits fatty_acid_synthase expression in EGF-stimulated human breast_cancer cells via the regulation of EGFR/ErbB -2 signaling .
11574756	0	Theophylline	0,12	CD4	40,43	Theophylline	CD4	MESH:D013806	920	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Theophylline inhibits TNF-alpha-induced CD4 expression on human eosinophils and CD4 + eosinophil migration .
2363749	0	Theophylline	0,12	COPD	67,71	Theophylline	COPD	MESH:D013806	260431	Chemical	Gene	concentrations|amod|START_ENTITY concentrations|nmod|END_ENTITY	Theophylline concentrations in patients with acute exacerbation of COPD .
9656574	0	Theophylline	1,13	ECP	38,41	Theophylline	ECP	MESH:D013806	6037	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|levels levels|nmod|END_ENTITY	-LSB- Theophylline reduces serum levels of ECP in vitro -RSB- .
12876409	0	Theophylline	0,12	IL-5	24,28	Theophylline	IL-5	MESH:D013806	3567	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|production production|amod|END_ENTITY	Theophylline suppresses IL-5 and IL-13 production , and lymphocyte proliferation upon stimulation with house_dust_mite in asthmatic children .
26574643	0	Theophylline	0,12	IL-8	23,27	Theophylline	IL-8	MESH:D013806	3576	Chemical	Gene	Secretion|compound|START_ENTITY Secretion|compound|END_ENTITY	Theophylline Represses IL-8 Secretion From ASM Cells Independently of PDE Inhibition : Novel Role as a PP2A Activator .
12065913	0	Theophylline	0,12	NF-kappaB	22,31	Theophylline	NF-kappaB	MESH:D013806	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	Theophylline inhibits NF-kappaB activation in human peripheral blood mononuclear cells .
11770011	0	Theophylline	0,12	NF-kappa_B	22,32	Theophylline	NF-kappa B	MESH:D013806	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	Theophylline inhibits NF-kappa_B activation and I_kappa_B_alpha degradation in human pulmonary epithelial cells .
6935624	0	Theophylline	0,12	cerebroside-sulfotransferase	37,65	Theophylline	cerebroside-sulfotransferase	MESH:D013806	53897(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|activity activity|nmod|END_ENTITY	Theophylline reduces the activity of cerebroside-sulfotransferase , a key enzyme in myelination , in cell cultures from newborn mouse brain .
12904930	0	Theophylline	0,12	erythropoietin	107,121	Theophylline	erythropoietin	MESH:D013806	2056	Chemical	Gene	treatment|amod|START_ENTITY affect|nsubj|treatment affect|advcl|suppressing suppressing|dobj|production production|compound|END_ENTITY	Theophylline treatment may adversely affect the anoxia-induced erythropoietic response without suppressing erythropoietin production .
3111805	0	Theophylline	0,12	growth_hormone	60,74	Theophylline	growth hormone	MESH:D013806	2688	Chemical	Gene	treatment|amod|START_ENTITY treatment|dep|effect effect|nmod|END_ENTITY	Theophylline treatment in the neonate with apnea : effect on growth_hormone , thyroid hormone and TRH induced TSH secretion .
9741061	0	Theophylline	0,12	histamine_H3-receptor	38,59	Theophylline	histamine H3-receptor	MESH:D013806	11255	Chemical	Gene	START_ENTITY|nmod|antagonists antagonists|amod|END_ENTITY	Theophylline derivatives as potential histamine_H3-receptor antagonists .
15337792	0	Theophylline	0,12	histone_deacetylase	22,41	Theophylline	histone deacetylase	MESH:D013806	9734	Chemical	Gene	restores|nsubj|START_ENTITY restores|dobj|activity activity|amod|END_ENTITY	Theophylline restores histone_deacetylase activity and steroid responses in COPD macrophages .
9430494	0	Theophylline	0,12	interleukin-4	39,52	Theophylline	interleukin-4	MESH:D013806	3565	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|release release|nmod|END_ENTITY	Theophylline suppresses the release of interleukin-4 by peripheral blood mononuclear cells .
10837466	0	Theromin	0,8	thrombin	24,32	Theromin	thrombin	MESH:C415362	2147	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Theromin , a novel leech thrombin inhibitor .
18086528	0	Thiahomoisocitrate	0,18	homoisocitrate_dehydrogenase	49,77	Thiahomoisocitrate	homoisocitrate dehydrogenase	null	854714(Tax:4932)	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	Thiahomoisocitrate : a highly potent inhibitor of homoisocitrate_dehydrogenase involved in the alpha-aminoadipate pathway .
25707023	0	Thiamine	0,8	SLC19A2	70,77	Thiamine	SLC19A2	MESH:D013831	10560	Chemical	Gene	responsive|amod|START_ENTITY megaloblastic_anemia_syndrome|amod|responsive megaloblastic_anemia_syndrome|dep|mutation mutation|compound|END_ENTITY	Thiamine responsive megaloblastic_anemia_syndrome : A novel homozygous SLC19A2 gene mutation identified .
26549656	0	Thiamine	71,79	SLC19A2	50,57	Thiamine	SLC19A2	MESH:D013831	10560	Chemical	Gene	Megaloblastic_Anemia|compound|START_ENTITY causing|dobj|Megaloblastic_Anemia mutation|acl|causing mutation|nmod|gene gene|compound|END_ENTITY	Novel nonsense mutation -LRB- p.Ile411Metfs * 12 -RRB- in the SLC19A2 gene causing Thiamine Responsive Megaloblastic_Anemia in an Indian patient .
25117056	0	Thiamine	0,8	SLC19A3	95,102	Thiamine	SLC19A3	MESH:D013831	486151(Tax:9615)	Chemical	Gene	Pathology|compound|START_ENTITY Pathology|nmod|END_ENTITY	Thiamine Deficiency-Mediated Brain Mitochondrial Pathology in Alaskan Huskies with Mutation in SLC19A3 .1 .
26528626	0	Thiamine	52,60	SLC19A3	82,89	Thiamine	SLC19A3	MESH:D013831	80704	Chemical	Gene	Transporter|compound|START_ENTITY Substrate|nmod|Transporter THTR-2|compound|Substrate THTR-2|appos|END_ENTITY	Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter , THTR-2 -LRB- SLC19A3 -RRB- .
9521628	0	Thiamine	0,8	transketolase	43,56	Thiamine	transketolase	MESH:D013831	7086	Chemical	Gene	deficiency|amod|START_ENTITY decreases|nsubj|deficiency decreases|dobj|END_ENTITY	Thiamine deficiency decreases steady-state transketolase and pyruvate dehydrogenase but not alpha-ketoglutarate dehydrogenase mRNA levels in three human cell types .
6120164	0	Thiazolidine-2-carboxylic_acid	0,30	D-amino_acid_oxidase	91,111	Thiazolidine-2-carboxylic acid	D-amino acid oxidase	MESH:C021760	1610	Chemical	Gene	START_ENTITY|nmod|substrate substrate|nmod|END_ENTITY	Thiazolidine-2-carboxylic_acid , an adduct of cysteamine and glyoxylate , as a substrate for D-amino_acid_oxidase .
18509487	0	Thiazolidinedione	11,28	PPAR-gamma	0,10	Thiazolidinedione	PPAR-gamma	MESH:C089946	5468	Chemical	Gene	Agonists|compound|START_ENTITY Agonists|compound|END_ENTITY	PPAR-gamma Thiazolidinedione Agonists and Immunotherapy in the Treatment of Brain_Tumors .
19783142	0	Thiazolidinedione	0,17	PTP1B	33,38	Thiazolidinedione	PTP1B	MESH:C089946	19246(Tax:10090)	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Thiazolidinedione derivatives as PTP1B inhibitors with antihyperglycemic and antiobesity effects .
10386610	0	Thiazolidinedione	0,17	RANTES	41,47	Thiazolidinedione	RANTES	MESH:C089946	6352	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|nmod|END_ENTITY	Thiazolidinedione inhibits production of RANTES in a cytokine-treated human lung epithelial cell line .
12063547	0	Thiazolidinedione	0,17	peroxisome_proliferator-activated_receptor-gamma	21,69	Thiazolidinedione	peroxisome proliferator-activated receptor-gamma	MESH:C089946	5468	Chemical	Gene	START_ENTITY|appos|ligand ligand|amod|END_ENTITY	Thiazolidinedione , a peroxisome_proliferator-activated_receptor-gamma ligand , modulates the E-cadherin/beta-catenin system in a human pancreatic_cancer cell line , BxPC-3 .
12082115	0	Thiazolidinedione	0,17	peroxisome_proliferator-activated_receptor_gamma	32,80	Thiazolidinedione	peroxisome proliferator-activated receptor gamma	MESH:C089946	5468	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Thiazolidinedione activation of peroxisome_proliferator-activated_receptor_gamma can enhance mitochondrial potential and promote cell survival .
23034049	0	Thiazolidinediones	0,18	CXCL10	73,79	Thiazolidinediones	CXCL10	MESH:D045162	3627	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|release release|nmod|END_ENTITY	Thiazolidinediones inhibit airway smooth muscle release of the chemokine CXCL10 : in vitro comparison with current asthma therapies .
12613669	0	Thiazolidinediones	0,18	Id2	60,63	Thiazolidinediones	Id2	MESH:D045162	3398	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|expression expression|amod|END_ENTITY	Thiazolidinediones , a class of anti-diabetic drugs , inhibit Id2 expression through a PPARgamma-independent pathway in human aortic smooth muscle cells .
11278997	0	Thiazolidinediones	0,18	P450c17	80,87	Thiazolidinediones	P450c17	MESH:D045162	1586	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|END_ENTITY	Thiazolidinediones but not metformin directly inhibit the steroidogenic enzymes P450c17 and 3beta _ - hydroxysteroid dehydrogenase .
21720023	0	Thiazolidinediones	0,18	fibroblast_growth_factor_21	42,69	Thiazolidinediones	fibroblast growth factor 21	MESH:D045162	56636(Tax:10090)	Chemical	Gene	inducers|nsubj|START_ENTITY inducers|nmod|expression expression|amod|END_ENTITY	Thiazolidinediones are potent inducers of fibroblast_growth_factor_21 expression in the liver .
10052651	0	Thiazolidinediones	0,18	insulin	28,35	Thiazolidinediones	insulin	MESH:D045162	3630	Chemical	Gene	START_ENTITY|dep|enhancers enhancers|compound|END_ENTITY	Thiazolidinediones -- the new insulin enhancers .
15684639	0	Thiazolidinediones	0,18	insulin	52,59	Thiazolidinediones	insulin	MESH:D045162	3630	Chemical	Gene	START_ENTITY|dep|review review|nmod|mechanisms mechanisms|nmod|sensitization sensitization|compound|END_ENTITY	Thiazolidinediones : a review of their mechanisms of insulin sensitization , therapeutic potential , clinical efficacy , and tolerability .
17161222	0	Thiazolidinediones	0,18	insulin	36,43	Thiazolidinediones	insulin	MESH:D045162	3630	Chemical	Gene	increase|nsubj|START_ENTITY increase|dobj|extraction extraction|compound|END_ENTITY	Thiazolidinediones increase hepatic insulin extraction in African Americans with impaired_glucose_tolerance_and_type_2_diabetes_mellitus .
17906687	0	Thiazolidinediones	0,18	insulin	31,38	Thiazolidinediones	insulin	MESH:D045162	3630	Chemical	Gene	START_ENTITY|dep|effects effects|nmod|resistance resistance|compound|END_ENTITY	Thiazolidinediones : effects on insulin resistance and the cardiovascular system .
8922349	0	Thiazolidinediones	0,18	insulin	39,46	Thiazolidinediones	insulin	MESH:D045162	3630	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	Thiazolidinediones in the treatment of insulin resistance and type_II_diabetes .
9748292	0	Thiazolidinediones	0,18	lipoprotein_lipase	27,45	Thiazolidinediones	lipoprotein lipase	MESH:D045162	4023	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|activity activity|amod|END_ENTITY	Thiazolidinediones inhibit lipoprotein_lipase activity in adipocytes .
16513826	0	Thiazolidinediones	0,18	peroxisome_proliferator-activated_receptor-gamma	200,248	Thiazolidinediones	peroxisome proliferator-activated receptor-gamma	MESH:D045162	5468	Chemical	Gene	induce|nsubj|START_ENTITY induce|parataxis|controls controls|nmod|adipocytes adipocytes|nmod|coactivation coactivation|amod|END_ENTITY	Thiazolidinediones and rexinoids induce peroxisome_proliferator-activated_receptor-coactivator -LRB- PGC -RRB- -1 alpha gene transcription : an autoregulatory loop controls PGC-1alpha expression in adipocytes via peroxisome_proliferator-activated_receptor-gamma coactivation .
11500181	0	Thiazolidinediones	0,18	peroxisome_proliferator-activated_receptor_gamma	20,68	Thiazolidinediones	peroxisome proliferator-activated receptor gamma	MESH:D045162	5468	Chemical	Gene	START_ENTITY|appos|agonists agonists|amod|END_ENTITY	Thiazolidinediones , peroxisome_proliferator-activated_receptor_gamma agonists , regulate endothelial cell growth and secretion of vasoactive peptides .
12464670	0	Thiazolidinone	0,14	CFTR	15,19	Thiazolidinone	CFTR	CHEBI:48891	12638(Tax:10090)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion .
12546415	0	Thielavins	0,10	glucose-6-phosphatase	14,35	Thielavins	glucose-6-phosphatase	null	25634(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Thielavins as glucose-6-phosphatase -LRB- G6Pase -RRB- inhibitors : producing strain , fermentation , isolation , structural elucidation and biological activities .
25278768	0	Thieno-Triazolodiazepines	62,87	Apolipoprotein_A-I	23,41	Thieno-Triazolodiazepines	Apolipoprotein A-I	null	335	Chemical	Gene	Production|nmod|START_ENTITY Production|compound|END_ENTITY	Stimulation of Hepatic Apolipoprotein_A-I Production by Novel Thieno-Triazolodiazepines : Roles of the Classical Benzodiazepine Receptor , PAF Receptor , and Bromodomain Binding .
17188869	0	Thienopyridine	0,14	KDR	34,37	Thienopyridine	KDR	MESH:C446540	16542(Tax:10090)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Thienopyridine urea inhibitors of KDR kinase .
20833036	0	Thienopyrimidines	0,17	b3-adrenoceptor	21,36	Thienopyrimidines	b3-adrenoceptor	null	155	Chemical	Gene	START_ENTITY|nmod|agonists agonists|amod|END_ENTITY	Thienopyrimidines as b3-adrenoceptor agonists : hit-to-lead optimization .
21316222	0	Thienopyrrole_acetic_acids	0,26	CRTH2	49,54	Thienopyrrole acetic acids	CRTH2	null	14764(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	Thienopyrrole_acetic_acids as antagonists of the CRTH2 receptor .
24059332	0	Thienyl_pyrimidine	0,18	PrP	36,39	Thienyl pyrimidine	PrP	null	5621	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Thienyl_pyrimidine derivatives with PrP -LRB- Sc -RRB- oligomer-inducing activity are a promising tool to study prions .
27043661	0	Thio-2	21,27	Bag-1	4,9	Thio-2	Bag-1	null	573	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	The Bag-1 inhibitor , Thio-2 , reverses an atypical 3D morphology driven by Bag-1L overexpression in a MCF-10A model of ductal_carcinoma in situ .
2002037	0	Thiocyanate	0,11	eosinophil_peroxidase	39,60	Thiocyanate	eosinophil peroxidase	MESH:C031760	303414(Tax:10116)	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Thiocyanate is the major substrate for eosinophil_peroxidase in physiologic fluids .
15169827	0	Thioether	0,9	serotonin_transporter	107,128	Thioether	serotonin transporter	CHEBI:16385	6532	Chemical	Gene	metabolites|amod|START_ENTITY metabolites|nmod|END_ENTITY	Thioether metabolites of 3,4-methylenedioxyamphetamine and 3,4-methylenedioxymethamphetamine inhibit human serotonin_transporter -LRB- hSERT -RRB- function and simultaneously stimulate dopamine uptake into hSERT-expressing SK-N-MC cells .
20363633	0	Thioether_benzenesulfonamide	0,28	carbonic_anhydrases_II_and_IV	43,72	Thioether benzenesulfonamide	carbonic anhydrases II and IV	null	100009156(Tax:9986)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Thioether_benzenesulfonamide inhibitors of carbonic_anhydrases_II_and_IV : structure-based drug design , synthesis , and biological evaluation .
17505558	0	Thioglycosides	0,14	hSGLT1	32,38	Thioglycosides	hSGLT1	MESH:D013865	6523	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Thioglycosides as inhibitors of hSGLT1 and hSGLT2 : potential therapeutic agents for the control of hyperglycemia in diabetes .
8961948	0	Thiol	0,5	CCl4	60,64	Thiol	CCl4	CHEBI:29256	116637(Tax:10116)	Chemical	Gene	oxidation|amod|START_ENTITY oxidation|nmod|END_ENTITY	Thiol oxidation and cytochrome P450-dependent metabolism of CCl4 triggers Ca2 + release from liver microsomes .
7476933	0	Thiol	0,5	MnSOD	47,52	Thiol	MnSOD	CHEBI:29256	6648	Chemical	Gene	modulation|amod|START_ENTITY END_ENTITY|nsubj|modulation	Thiol modulation of TNF_alpha and IL-1 induced MnSOD gene expression and activation of NF-kappa_B .
7476933	0	Thiol	0,5	NF-kappa_B	87,97	Thiol	NF-kappa B	CHEBI:29256	4790	Chemical	Gene	modulation|amod|START_ENTITY MnSOD|nsubj|modulation MnSOD|dobj|expression expression|nmod|END_ENTITY	Thiol modulation of TNF_alpha and IL-1 induced MnSOD gene expression and activation of NF-kappa_B .
8522579	0	Thiol	0,5	NF-kappa_B	125,135	Thiol	NF-kappa B	CHEBI:29256	18033(Tax:10090)	Chemical	Gene	agents|amod|START_ENTITY identify|nsubj|agents identify|dobj|pathway pathway|acl:relcl|requires requires|dobj|activation activation|nmod|END_ENTITY	Thiol agents and Bcl-2 identify an alphavirus-induced apoptotic pathway that requires activation of the transcription factor NF-kappa_B .
3698895	0	Thiol	0,5	prolactin	60,69	Thiol	prolactin	CHEBI:29256	24683(Tax:10116)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Thiol regulation of depletion-transformation and release of prolactin by the pituitary of the lactating rat .
16793007	0	Thiol	0,5	vascular_endothelial_growth_factor-A	20,56	Thiol	vascular endothelial growth factor-A	CHEBI:29256	7422	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Thiol regulation of vascular_endothelial_growth_factor-A and its receptors in human retinal pigment epithelial cells .
8958489	0	Thiopentone	0,11	FMLP	127,131	Thiopentone	FMLP	MESH:D013874	2357	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|nmod|END_ENTITY	Thiopentone and propofol , but not methohexitone nor midazolam , inhibit neutrophil oxidative responses to the bacterial peptide FMLP .
21111619	0	Thiophene	0,9	MMP12	45,50	Thiophene	MMP12	CHEBI:30856	4321	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Thiophene and bioisostere derivatives as new MMP12 inhibitors .
22030030	0	Thiophene	0,9	PDE4	24,28	Thiophene	PDE4	CHEBI:30856	5141	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Thiophene inhibitors of PDE4 : crystal structures show a second binding mode at the catalytic domain of PDE4D2 .
24666646	0	Thiophene_carboxamide	0,21	JAK2	36,40	Thiophene carboxamide	JAK2	null	3717	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Thiophene_carboxamide inhibitors of JAK2 as potential treatments for myleoproliferative_neoplasms .
239662	0	Thioridazine	0,12	prolactin	24,33	Thioridazine	prolactin	MESH:D013881	5617	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|compound|END_ENTITY	Thioridazine stimulates prolactin secretion in man .
21908407	0	Thiostrepton	0,12	elongation_factor_G	94,113	Thiostrepton	elongation factor G	MESH:D013883	85476	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Thiostrepton inhibits stable 70S ribosome binding and ribosome-dependent GTPase activation of elongation_factor_G and elongation_factor_4 .
25200837	0	Thiotanib	26,35	Bcr-Abl	44,51	Thiotanib	Bcr-Abl	null	25	Chemical	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Tyrosine_kinase inhibitor Thiotanib targets Bcr-Abl and induces apoptosis and autophagy in human chronic_myeloid_leukemia cells .
436767	0	Thiourea	0,8	thyroid_peroxidase	40,58	Thiourea	thyroid peroxidase	MESH:D013890	54314(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Thiourea and cyanamide as inhibitors of thyroid_peroxidase : the role of iodide .
16857225	0	Thiram	114,120	11-beta_hydroxysteroid_dehydrogenase_type_2	59,102	Thiram	11-beta hydroxysteroid dehydrogenase type 2	MESH:D013893	3291	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Reduction of glucocorticoid_receptor ligand binding by the 11-beta_hydroxysteroid_dehydrogenase_type_2 inhibitor , Thiram .
16849607	0	Thr-Gly	16,23	period	4,10	Thr-Gly	period	MESH:C400974	31251(Tax:7227)	Chemical	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	The period gene Thr-Gly polymorphism in Australian and African Drosophila_melanogaster populations : implications for selection .
19565571	0	Threonine	0,9	Axin	57,61	Threonine	Axin	CHEBI:26986	398097(Tax:8355)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Threonine 393 of beta-catenin regulates interaction with Axin .
25446991	0	Threonine	0,9	Bcl-2	32,37	Threonine	Bcl-2	CHEBI:26986	596	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Threonine 56 phosphorylation of Bcl-2 is required for LRRK2 G2019S-induced mitochondrial depolarization and autophagy .
26562480	0	Threonine	0,9	ClC-3	33,38	Threonine	ClC-3	CHEBI:26986	12725(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Threonine 532 phosphorylation in ClC-3 is required for angiotensin_II-induced Cl -LRB- - -RRB- current and migration in cultured vascular smooth muscle cells .
21664921	0	Threonine	27,36	Nbs1	22,26	Threonine	Nbs1	CHEBI:26986	27354(Tax:10090)	Chemical	Gene	site|compound|START_ENTITY site|amod|END_ENTITY	Point mutation at the Nbs1 Threonine 278 site does not affect mouse development , but compromises the Chk2 and Smc1 phosphorylation after DNA damage .
25724654	0	Threonine	57,66	Norepinephrine_Transporter	80,106	Threonine	Norepinephrine Transporter	CHEBI:26986	20538(Tax:10090)	Chemical	Gene	Regulation|compound|START_ENTITY Regulation|compound|END_ENTITY	A Role for p38_Mitogen-activated_Protein_Kinase-mediated Threonine 30-dependent Norepinephrine_Transporter Regulation in Cocaine Sensitization and Conditioned Place Preference .
20403402	0	Threonine	0,9	PICK1	34,39	Threonine	PICK1	CHEBI:26986	9463	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Threonine 82 at the PDZ domain of PICK1 is critical for AMPA receptor interaction and localization .
26436659	0	Threonine	19,28	Tie1	36,40	Threonine	Tie1	CHEBI:26986	30746(Tax:7955)	Chemical	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of Threonine 794 on Tie1 by Rac1/PAK1 Reveals a Novel Angiogenesis Regulatory Pathway .
11085506	0	Threonine	0,9	ataxia_telangiectasia_mutated	32,61	Threonine	ataxia telangiectasia mutated	CHEBI:26986	472	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Threonine 68 phosphorylation by ataxia_telangiectasia_mutated is required for efficient activation of Chk2 in response to ionizing radiation .
17052767	0	Threonine	0,9	integrin_beta3	29,43	Threonine	integrin beta3	CHEBI:26986	3690	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Threonine phosphorylation of integrin_beta3 in calyculin_A-treated platelets is selectively sensitive to 5 ' - iodotubercidin .
12819209	0	Threonine	0,9	prolactin_receptor	43,61	Threonine	prolactin receptor	CHEBI:26986	5618	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Threonine 391 phosphorylation of the human prolactin_receptor mediates a novel interaction with 14-3-3 proteins .
15781331	0	Thrombopoietin	0,14	MPL	98,101	Thrombopoietin	MPL	MESH:D013926	4352	Chemical	Gene	supports|nsubj|START_ENTITY supports|parataxis|+ +|nsubj|END_ENTITY	Thrombopoietin alone or in the presence of stem_cell_factor supports the growth of KIT -LRB- CD117 -RRB- low / MPL -LRB- CD110 -RRB- + human mast cells from hematopoietic progenitor cells .
15095485	0	Thrombopoietin	0,14	Mpl	25,28	Thrombopoietin	Mpl	MESH:D013926	4352	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Thrombopoietin receptor -LRB- Mpl -RRB- expression by megakaryocytes in myeloproliferative_disorders .
8675818	0	Thrombospondin	0,14	CD36	25,29	Thrombospondin	CD36	null	948	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Thrombospondin receptor -LRB- CD36 -RRB- expression of human keratinocytes during wound healing in a SCID mouse/human skin repair model .
3818582	0	Thrombospondin	0,14	fibrinogen	32,42	Thrombospondin	fibrinogen	null	2244	Chemical	Gene	interaction|nsubj|START_ENTITY interaction|nmod|END_ENTITY	Thrombospondin interaction with fibrinogen .
1531022	0	Thrombospondin	0,14	plasmin	52,59	Thrombospondin	plasmin	null	5340	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Thrombospondin is a slow tight-binding inhibitor of plasmin .
18675774	1	Thrombospondin-1	120,136	CD-47	186,191	Thrombospondin-1	TSP-1	null	7057	Chemical	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	Thrombospondin-1 -LRB- TSP-1 -RRB- interaction with the membranous receptor CD-47 involves the peptide RFYVVMWK -LRB- 4N-1 -RRB- located in its C-terminal domain .
1837063	0	Thromboxane	0,11	angiotensin_II	59,73	Thromboxane	angiotensin II	CHEBI:26995	24179(Tax:10116)	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Thromboxane mediates renal hemodynamic response to infused angiotensin_II .
7537434	0	Thromboxane_A2	0,14	DP-1904	35,42	Thromboxane A2	DP-1904	MESH:D013928	2944390(Tax:177439)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Thromboxane_A2 synthase inhibitor , DP-1904 , decreases TNF_alpha secretion from monocytes and inhibits E-selectin and ICAM-1 expression on the endothelial cell surfaces .
15647606	0	Thromboxane_A2	0,14	endothelin-1	106,118	Thromboxane A2	endothelin-1	MESH:D013928	24323(Tax:10116)	Chemical	Gene	contributes|nsubj|START_ENTITY contributes|nmod|END_ENTITY	Thromboxane_A2 from Kupffer cells contributes to the hyperresponsiveness of hepatic portal circulation to endothelin-1 in endotoxemic rats .
10759766	0	Thromboxane_A2	0,14	monocyte_chemoattractant_protein-1	51,85	Thromboxane A2	monocyte chemoattractant protein-1	MESH:D013928	6347	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Thromboxane_A2 -LRB- TXA2 -RRB- receptor blockade suppresses monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- expression by stimulated vascular endothelial cells .
12722680	0	Thymidine	1,10	DPD	44,47	Thymidine	DPD	MESH:D013936	1806	Chemical	Gene	correlated|nsubjpass|START_ENTITY correlated|nmod|END_ENTITY	-LSB- Thymidine phosphorylase is correlated with DPD in colon_cancer -RSB- .
23217244	0	Thymidylate	0,11	TYMS	27,31	Thymidylate	TYMS	CHEBI:17013	7298	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Thymidylate synthase gene -LRB- TYMS -RRB- polymorphisms in sporadic and hereditary_breast_cancer .
19020767	0	Thymidylate	0,11	dihydropyrimidine_dehydrogenase	22,53	Thymidylate	dihydropyrimidine dehydrogenase	CHEBI:17013	1806	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	Thymidylate synthase , dihydropyrimidine_dehydrogenase , orotate_phosphoribosyltransferase mRNA and protein expression levels in solid tumors in large scale population analysis .
21791367	0	Thymidylate	0,11	dihydropyrimidine_dehydrogenase	22,53	Thymidylate	dihydropyrimidine dehydrogenase	CHEBI:17013	1806	Chemical	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	Thymidylate synthase , dihydropyrimidine_dehydrogenase , thymidine_phosphorylase , orotate_phosphoribosyltransferase mRNA expression in lung cancer metastatic lymph node samples obtained by endobronchial ultrasound-guided transbronchial needle aspiration : a pilot study .
21791367	0	Thymidylate	0,11	orotate_phosphoribosyltransferase	80,113	Thymidylate	orotate phosphoribosyltransferase	CHEBI:17013	7372	Chemical	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	Thymidylate synthase , dihydropyrimidine_dehydrogenase , thymidine_phosphorylase , orotate_phosphoribosyltransferase mRNA expression in lung cancer metastatic lymph node samples obtained by endobronchial ultrasound-guided transbronchial needle aspiration : a pilot study .
21791367	0	Thymidylate	0,11	thymidine_phosphorylase	55,78	Thymidylate	thymidine phosphorylase	CHEBI:17013	1890	Chemical	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	Thymidylate synthase , dihydropyrimidine_dehydrogenase , thymidine_phosphorylase , orotate_phosphoribosyltransferase mRNA expression in lung cancer metastatic lymph node samples obtained by endobronchial ultrasound-guided transbronchial needle aspiration : a pilot study .
23911786	0	Thymoquinone	0,12	COX-2	82,87	Thymoquinone	COX-2	MESH:C003466	19225(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	Thymoquinone inhibits phorbol_ester-induced activation of NF-kB and expression of COX-2 , and induces expression of cytoprotective enzymes in mouse skin in vivo .
21040738	0	Thymoquinone	0,12	PTEN	26,30	Thymoquinone	PTEN	MESH:C003466	5728	Chemical	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|compound|END_ENTITY	Thymoquinone up-regulates PTEN expression and induces apoptosis in doxorubicin-resistant human breast_cancer cells .
24890449	0	Thymoquinone	0,12	STAT3	90,95	Thymoquinone	STAT3	MESH:C003466	6774	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|inactivation inactivation|nmod|END_ENTITY	Thymoquinone induces apoptosis in human colon_cancer HCT116 cells through inactivation of STAT3 by blocking JAK2 - and Src - mediated phosphorylation of EGF receptor tyrosine kinase .
24355171	0	Thymoquinone	0,12	heme_oxygenase-1	21,37	Thymoquinone	heme oxygenase-1	MESH:C003466	3162	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Thymoquinone induces heme_oxygenase-1 expression in HaCaT cells via Nrf2/ARE activation : Akt and AMPKa as upstream targets .
8282541	0	Thymosin	0,8	interleukin-6	20,33	Thymosin	interleukin-6	MESH:D013947	24498(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|amod|END_ENTITY	Thymosin stimulates interleukin-6 production from rat spleen cells in vitro .
10408970	0	Thymulin	0,8	c-fos	17,22	Thymulin	c-fos	MESH:D013935	314322(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Thymulin induces c-fos expression in the spinal cord of rats which is reversed by meloxicam and morphine .
26485468	0	Thyroid_Hormone	0,15	Liver_Receptor_Homolog-1	83,107	Thyroid Hormone	Liver Receptor Homolog-1	CHEBI:60311	26424(Tax:10090)	Chemical	Gene	Regulates|nsubj|START_ENTITY Regulates|nmod|END_ENTITY	Thyroid_Hormone Regulates the mRNA Expression of Small_Heterodimer_Partner through Liver_Receptor_Homolog-1 .
26485468	0	Thyroid_Hormone	0,15	Small_Heterodimer_Partner	49,74	Thyroid Hormone	Small Heterodimer Partner	CHEBI:60311	23957(Tax:10090)	Chemical	Gene	Regulates|nsubj|START_ENTITY Regulates|dobj|Expression Expression|nmod|END_ENTITY	Thyroid_Hormone Regulates the mRNA Expression of Small_Heterodimer_Partner through Liver_Receptor_Homolog-1 .
12846840	0	Thyroid_hormone	0,15	4-1BB	42,47	Thyroid hormone	4-1BB	CHEBI:60311	500590(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Thyroid_hormone induces the expression of 4-1BB and activation of caspases in a thyroid hormone receptor-dependent manner .
16171808	0	Thyroid_hormone	0,15	Akt	26,29	Thyroid hormone	Akt	CHEBI:60311	24185(Tax:10116)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Thyroid_hormone activates Akt and prevents serum starvation-induced cell death in neonatal rat cardiomyocytes .
8770660	0	Thyroid_hormone	0,15	BCL-2	25,30	Thyroid hormone	BCL-2	CHEBI:60311	24224(Tax:10116)	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|compound|END_ENTITY	Thyroid_hormone promotes BCL-2 expression and prevents apoptosis of early differentiating cerebellar granule neurons .
20926779	0	Thyroid_hormone	0,15	ERK	25,28	Thyroid hormone	ERK	CHEBI:60311	26413(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Thyroid_hormone inhibits ERK phosphorylation in pressure overload-induced hypertrophied mouse hearts through a receptor-mediated mechanism .
23305647	0	Thyroid_hormone	0,15	MAFA	118,122	Thyroid hormone	MAFA	CHEBI:60311	366949(Tax:10116)	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Thyroid_hormone promotes postnatal rat pancreatic b-cell development and glucose-responsive_insulin secretion through MAFA .
9056383	0	Thyroid_hormone	0,15	NGF	26,29	Thyroid hormone	NGF	CHEBI:60311	310738(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Thyroid_hormone regulates NGF content and p75LNGFR expression in the basal forebrain of adult rats .
9886925	0	Thyroid_hormone	0,15	NHE3	52,56	Thyroid hormone	NHE3	CHEBI:60311	24784(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Thyroid_hormone stimulates the renal Na/H exchanger NHE3 by transcriptional activation .
25284282	0	Thyroid_hormone	0,15	PI3K	70,74	Thyroid hormone	PI3K	CHEBI:60311	298947(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|proliferation proliferation|nmod|END_ENTITY	Thyroid_hormone inhibits the proliferation of piglet Sertoli cell via PI3K signaling pathway .
16024569	0	Thyroid_hormone	0,15	PPARalpha	31,40	Thyroid hormone	PPARalpha	CHEBI:60311	100190976(Tax:9940)	Chemical	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Thyroid_hormone interacts with PPARalpha and PGC-1 during mitochondrial maturation in sheep heart .
17909947	0	Thyroid_hormone	0,15	SNAP-25	44,51	Thyroid hormone	SNAP-25	CHEBI:60311	25012(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Thyroid_hormone regulates the expression of SNAP-25 during rat brain development .
10024519	0	Thyroid_hormone	0,15	STAT3	48,53	Thyroid hormone	STAT3	CHEBI:60311	6774	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Thyroid_hormone promotes the phosphorylation of STAT3 and potentiates the action of epidermal_growth_factor in cultured cells .
11703450	0	Thyroid_hormone	0,15	TAG-1	26,31	Thyroid hormone	TAG-1	CHEBI:60311	25356(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Thyroid_hormone regulates TAG-1 expression in the developing rat brain .
23770290	0	Thyroid_hormone	0,15	TGFb1	25,30	Thyroid hormone	TGFb1	CHEBI:60311	7040	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Thyroid_hormone inhibits TGFb1 induced renal tubular epithelial to mesenchymal transition by increasing miR34a expression .
11027684	0	Thyroid_hormone	0,15	acetyl-coA_carboxylase-alpha	27,55	Thyroid hormone	acetyl-coA carboxylase-alpha	CHEBI:60311	396504(Tax:9031)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|transcription transcription|amod|END_ENTITY	Thyroid_hormone stimulates acetyl-coA_carboxylase-alpha transcription in hepatocytes by modulating the composition of nuclear_receptor complexes bound to a thyroid hormone response element .
2474323	0	Thyroid_hormone	0,15	alpha-fetoprotein	26,43	Thyroid hormone	alpha-fetoprotein	CHEBI:60311	174	Chemical	Gene	effect|amod|START_ENTITY effect|nmod|END_ENTITY	Thyroid_hormone effect on alpha-fetoprotein and albumin coordinate expression by a human hepatoma cell line .
1323286	0	Thyroid_hormone	0,15	apolipoprotein_B	26,42	Thyroid hormone	apolipoprotein B	CHEBI:60311	338	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	Thyroid_hormone modulates apolipoprotein_B gene expression in HepG2 cells .
7918604	0	Thyroid_hormone	0,15	cholesterol_7_alpha-hydroxylase	34,65	Thyroid hormone	cholesterol 7 alpha-hydroxylase	CHEBI:60311	25428(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|amod|END_ENTITY	Thyroid_hormone rapidly increases cholesterol_7_alpha-hydroxylase mRNA levels in hypophysectomized rats .
15155277	0	Thyroid_hormone	0,15	erythropoietin	24,38	Thyroid hormone	erythropoietin	CHEBI:60311	2056	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Thyroid_hormone induces erythropoietin gene expression through augmented accumulation of hypoxia-inducible factor-1 .
16302185	0	Thyroid_hormone	0,15	gamma-glutamyl_transpeptidase	27,56	Thyroid hormone	gamma-glutamyl transpeptidase	CHEBI:60311	116568(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|xcomp|END_ENTITY	Thyroid_hormone stimulates gamma-glutamyl_transpeptidase in the developing rat cerebra and in astroglial cultures .
185609	0	Thyroid_hormone	0,15	growth_hormone	35,49	Thyroid hormone	growth hormone	CHEBI:60311	81668(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|synthesis synthesis|compound|END_ENTITY	Thyroid_hormone stimulates de novo growth_hormone synthesis in cultured GH1 cells : evidence for the accumulation of a rate limiting RNA species in the induction process .
2303160	0	Thyroid_hormone	0,15	insulin-like_growth_factor_I	45,73	Thyroid hormone	insulin-like growth factor I	CHEBI:60311	24482(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|nmod|END_ENTITY	Thyroid_hormone stimulates the production of insulin-like_growth_factor_I -LRB- IGF-I -RRB- by immature rat Sertoli cells .
21266512	0	Thyroid_hormone	0,15	kallikrein-binding_protein	38,64	Thyroid hormone	kallikrein-binding protein	CHEBI:60311	16625(Tax:10090)	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|amod|END_ENTITY	Thyroid_hormone and COUP-TF1 regulate kallikrein-binding_protein -LRB- KBP -RRB- gene expression .
2473388	0	Thyroid_hormone	0,15	keratin	37,44	Thyroid hormone	keratin	CHEBI:60311	397756(Tax:8355)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Thyroid_hormone induces constitutive keratin gene expression during Xenopus_laevis development .
3098965	0	Thyroid_hormone	0,15	lactase	27,34	Thyroid hormone	lactase	CHEBI:60311	116569(Tax:10116)	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|expression expression|amod|END_ENTITY	Thyroid_hormone effects on lactase expression by rat enterocytes .
11442001	0	Thyroid_hormone	0,15	myoglobin	27,36	Thyroid hormone	myoglobin	CHEBI:60311	59108(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Thyroid_hormone stimulates myoglobin expression in soleus and extensorum digitalis longus muscles of rats : concomitant alterations in the activities of Krebs cycle oxidative enzymes .
15489001	0	Thyroid_hormone	0,15	myoglobin	27,36	Thyroid hormone	myoglobin	CHEBI:60311	59108(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	Thyroid_hormone stimulates myoglobin gene expression in rat cardiac muscle .
1295750	0	Thyroid_hormone	0,15	nerve_growth_factor	35,54	Thyroid hormone	nerve growth factor	CHEBI:60311	310738(Tax:10116)	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|synthesis synthesis|compound|END_ENTITY	Thyroid_hormone promotes transient nerve_growth_factor synthesis in rat_cerebellar_neuroblasts .
1639217	0	Thyroid_hormone	0,15	nerve_growth_factor	43,62	Thyroid hormone	nerve growth factor	CHEBI:60311	18049(Tax:10090)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Thyroid_hormone and androgen regulation of nerve_growth_factor gene expression in the mouse submandibular gland .
26334191	0	Thyroid_hormone	0,15	neuroglobin	26,37	Thyroid hormone	neuroglobin	CHEBI:60311	85382(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Thyroid_hormone modulates neuroglobin and cytoglobin in rat brain .
11258898	0	Thyroid_hormone	0,15	p53	51,54	Thyroid hormone	p53	CHEBI:60311	7157	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Thyroid_hormone promotes serine phosphorylation of p53 by mitogen-activated protein kinase .
15388791	0	Thyroid_hormone	0,15	phosphatidylinositol_3-kinase	118,147	Thyroid hormone	phosphatidylinositol 3-kinase	CHEBI:60311	5295	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Thyroid_hormone induces rapid activation of Akt/protein kinase B-mammalian_target_of_rapamycin-p70S6K cascade through phosphatidylinositol_3-kinase in human fibroblasts .
22315222	0	Thyroid_hormone	0,15	protein_arginine_methyltransferase_1	26,62	Thyroid hormone	protein arginine methyltransferase 1	CHEBI:60311	399121(Tax:8355)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|amod|END_ENTITY	Thyroid_hormone activates protein_arginine_methyltransferase_1 expression by directly inducing c-Myc transcription during Xenopus intestinal stem cell development .
9124327	0	Thyroid_hormone	0,15	renin	27,32	Thyroid hormone	renin	CHEBI:60311	24715(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|synthesis synthesis|compound|END_ENTITY	Thyroid_hormone stimulates renin synthesis in rats without involving the sympathetic nervous system .
15919736	0	Thyroid_hormone	0,15	renin_and_ANG_II_receptor	26,51	Thyroid hormone	renin and ANG II receptor	CHEBI:60311	443310(Tax:9940)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|compound|END_ENTITY	Thyroid_hormone modulates renin_and_ANG_II_receptor expression in fetal sheep .
2365955	0	Thyroid_iodine	0,14	thyroglobulin	33,46	Thyroid iodine	thyroglobulin	null	7038	Chemical	Gene	START_ENTITY|dobj|level level|compound|END_ENTITY	Thyroid_iodine content and serum thyroglobulin level following external irradiation to the neck for Hodgkin 's _ disease .
2482456	0	Thyroliberin	0,12	prolactin	43,52	Thyroliberin	prolactin	MESH:D013973	24683(Tax:10116)	Chemical	Gene	modulate|nsubj|START_ENTITY modulate|dobj|expression expression|amod|END_ENTITY	Thyroliberin and dihydropyridines modulate prolactin gene expression through interacting pathways in GH3 cells .
1944297	0	Thyrotropin	0,11	glucose-regulated_protein	23,48	Thyrotropin	glucose-regulated protein	MESH:D013972	25617(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Thyrotropin stimulates glucose-regulated_protein -LRB- GRP78 -RRB- gene expression in rat functional thyroid epithelial cells , FRTL .
2503767	0	Thyrotropin	0,11	thyrotropin-releasing_hormone	58,87	Thyrotropin	thyrotropin-releasing hormone	MESH:D013972	7200	Chemical	Gene	responses|compound|START_ENTITY responses|nmod|END_ENTITY	Thyrotropin and prolactin responses to different doses of thyrotropin-releasing_hormone in depression .
6416271	0	Thyrotropin	0,11	thyrotropin-releasing_hormone	38,67	Thyrotropin	thyrotropin-releasing hormone	MESH:D013972	7200	Chemical	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	Thyrotropin and prolactin response to thyrotropin-releasing_hormone in healthy and asphyxiated full-term neonates .
820160	0	Thyrotropin	0,11	thyrotropin-releasing_hormone	24,53	Thyrotropin	thyrotropin-releasing hormone	MESH:D013972	7200	Chemical	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	Thyrotropin response to thyrotropin-releasing_hormone in fullterm , euthyroid and hypothyroid newborns .
98724	0	Thyrotropin	0,11	thyrotropin-releasing_hormone	73,102	Thyrotropin	thyrotropin-releasing hormone	MESH:D013972	613414(Tax:9913)	Chemical	Gene	patterns|compound|START_ENTITY patterns|nmod|END_ENTITY	Thyrotropin and prolactin secretory patterns during 24-hours infusion of thyrotropin-releasing_hormone in calves .
99181	0	Thyrotropin	0,11	thyrotropin-releasing_hormone	64,93	Thyrotropin	thyrotropin-releasing hormone	MESH:D013972	7200	Chemical	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	Thyrotropin , prolactin and growth_hormone response to synthetic thyrotropin-releasing_hormone in newborn infants .
12788086	0	Thyroxine	0,9	Sox9	24,28	Thyroxine	Sox9	MESH:D013974	6662	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	Thyroxine downregulates Sox9 and promotes chondrocyte hypertrophy .
3106949	6	Thyroxine	878,887	TRH	963,966	Thyroxine	TRH	MESH:D013974	414344(Tax:9031)	Chemical	Gene	concentrations|amod|START_ENTITY increased|nsubjpass|concentrations increased|nmod|END_ENTITY	Thyroxine concentrations in plasma were increased within 30 min of first exposure to TRH at 2 days of age , but they were unaffected by intermittent episodes of TRH at 7 , 14 , and 21 days of age .
26284425	0	Thyroxine	86,95	Type_2_Iodothyronine_Deiodinase	0,31	Thyroxine	Type 2 Iodothyronine Deiodinase	MESH:D013974	1734	Chemical	Gene	Required|nmod|START_ENTITY Required|nsubjpass|Activity Activity|compound|END_ENTITY	Type_2_Iodothyronine_Deiodinase Activity Is Required for Rapid Stimulation of PI3K by Thyroxine in Human Umbilical Vein Endothelial Cells .
10929090	0	Thyroxine	0,9	corticotropin-releasing_factor	20,50	Thyroxine	corticotropin-releasing factor	MESH:D013974	81648(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Thyroxine modulates corticotropin-releasing_factor but not arginine_vasopressin gene expression in the hypothalamic paraventricular nucleus of the developing Rat .
1999161	0	Thyroxine	0,9	epidermal_growth_factor	20,43	Thyroxine	epidermal growth factor	MESH:D013974	13645(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|compound|END_ENTITY	Thyroxine increases epidermal_growth_factor levels in the mouse thyroid in vivo .
8504737	0	Thyroxine	0,9	epidermal_growth_factor	34,57	Thyroxine	epidermal growth factor	MESH:D013974	13645(Tax:10090)	Chemical	Gene	increases|advmod|START_ENTITY increases|dobj|levels levels|nmod|messenger messenger|compound|END_ENTITY	Thyroxine increases the levels of epidermal_growth_factor messenger ribonucleic acid -LRB- EGF mRNA -RRB- in the thyroid in vivo , as revealed by quantitative reverse transcription polymerase chain reaction with an internal control EGF mRNA .
14584756	0	Thyroxine	0,9	insulin-like_growth_factor_I	27,55	Thyroxine	insulin-like growth factor I	MESH:D013974	3479	Chemical	Gene	effects|amod|START_ENTITY END_ENTITY|nsubj|effects	Thyroxine effects on serum insulin-like_growth_factor_I levels , anthropometric measures , and body composition in patients after thyroidectomy .
441732	0	Thyroxine	0,9	nerve_growth_factor	20,39	Thyroxine	nerve growth factor	MESH:D013974	18049(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|concentration concentration|compound|END_ENTITY	Thyroxine increases nerve_growth_factor concentration in adult mouse brain .
3129285	0	Thyroxine	0,9	thyronine-binding_globulin	27,53	Thyroxine	thyronine-binding globulin	MESH:D013974	81806(Tax:10116)	Chemical	Gene	START_ENTITY|xcomp|binding binding|xcomp|serum serum|dobj|END_ENTITY	Thyroxine binding to serum thyronine-binding_globulin in thyroidectomized adult and normal neonatal rats .
2507733	0	Thyroxine	0,9	thyroxine-binding_globulin	29,55	Thyroxine	thyroxine-binding globulin	MESH:D013974	6906	Chemical	Gene	decrease|nsubj|START_ENTITY decrease|dobj|levels levels|amod|END_ENTITY	Thyroxine may decrease serum thyroxine-binding_globulin levels .
12801486	0	Thyroxine	0,9	transglutaminase	21,37	Thyroxine	transglutaminase	MESH:D013974	2162	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|amod|END_ENTITY	Thyroxine stimulates transglutaminase activity in articular chondrocytes .
1537302	0	Thyroxine	0,9	transthyretin	119,132	Thyroxine	transthyretin	MESH:D013974	24856(Tax:10116)	Chemical	Gene	flavonoid|ccomp|START_ENTITY flavonoid|nmod|END_ENTITY	Thyroxine -LRB- T4 -RRB- transport and distribution in rats treated with EMD_21388 , a synthetic flavonoid that displaces T4 from transthyretin .
2309926	0	Thyroxine	0,9	transthyretin	44,57	Thyroxine	transthyretin	MESH:D013974	24856(Tax:10116)	Chemical	Gene	transport|advmod|START_ENTITY transport|nmod|brain brain|nmod|synthesis synthesis|compound|END_ENTITY	Thyroxine transport from blood to brain via transthyretin synthesis in choroid plexus .
7906282	0	Thyroxine	0,9	transthyretin	27,40	Thyroxine	transthyretin	MESH:D013974	7276	Chemical	Gene	119|amod|START_ENTITY 119|amod|binding binding|nmod|variants variants|compound|END_ENTITY	Thyroxine binding by human transthyretin variants : mutations at position 119 , but not position 54 , increase thyroxine binding affinity .
8345041	0	Thyroxine	0,9	transthyretin	28,41	Thyroxine	transthyretin	MESH:D013974	7276	Chemical	Gene	interactions|amod|START_ENTITY interactions|nmod|END_ENTITY	Thyroxine interactions with transthyretin : a comparison of 10 different naturally occurring human transthyretin variants .
8345041	0	Thyroxine	0,9	transthyretin	98,111	Thyroxine	transthyretin	MESH:D013974	7276	Chemical	Gene	interactions|amod|START_ENTITY interactions|dep|comparison comparison|amod|different different|dep|occurring occurring|dobj|variants variants|compound|END_ENTITY	Thyroxine interactions with transthyretin : a comparison of 10 different naturally occurring human transthyretin variants .
8810738	0	Thyroxine	0,9	transthyretin	21,34	Thyroxine	transthyretin	MESH:D013974	7276	Chemical	Gene	variants|amod|START_ENTITY variants|amod|binding binding|nmod|END_ENTITY	Thyroxine binding to transthyretin -LRB- TTR -RRB- variants -- two variants -LRB- TTR Pro 55 and TTR Met 111 -RRB- with a particularly low binding affinity .
9368688	0	Thyroxine	0,9	transthyretin	21,34	Thyroxine	transthyretin	MESH:D013974	7276	Chemical	Gene	START_ENTITY|xcomp|binding binding|xcomp|END_ENTITY	Thyroxine binding to transthyretin Met 119 .
7805852	0	Thyrsiferyl_23-acetate	0,22	PP2A	76,80	Thyrsiferyl 23-acetate	PP2A	MESH:C091148	5524	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Thyrsiferyl_23-acetate is a novel specific inhibitor of protein phosphatase PP2A .
7713911	0	Ti	89,91	ATPase	60,66	Ti	ATPase	null	3654511(Tax:562)	Chemical	Gene	component|nmod|START_ENTITY component|amod|END_ENTITY	Distinctive roles of the two ATP-binding sites in ClpA , the ATPase component of protease Ti in Escherichia_coli .
9372193	0	Ti	88,90	ATPase	59,65	Ti	ATPase	null	3654511(Tax:562)	Chemical	Gene	component|nmod|START_ENTITY component|amod|END_ENTITY	Site-directed mutagenesis of the Cys residues in ClpA , the ATPase component of protease Ti -LRB- ClpAP -RRB- in Escherichia_coli .
2145389	0	Ti	156,158	CD3	170,173	Ti	CD3	null	12503(Tax:10090)	Chemical	Gene	isoforms|compound|START_ENTITY isoforms|compound|END_ENTITY	Characterization of thymus-derived lymphocytes expressing Ti alpha-beta CD3 gamma delta epsilon zeta-zeta , Ti alpha-beta CD3 gamma delta epsilon eta-eta or Ti alpha-beta CD3 gamma delta epsilon zeta-zeta/zeta-eta antigen receptor isoforms : analysis by gene transfection .
18606801	0	Ti	139,141	TraM	120,124	Ti	TraM	null	1224219(Tax:358)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Broad-host-range expression vectors with tightly regulated promoters and their use to examine the influence of TraR and TraM expression on Ti plasmid quorum sensing .
9079917	0	Ti	25,27	VirA	44,48	Ti	VirA	null	6381972(Tax:358)	Chemical	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Variable efficiency of a Ti plasmid-encoded VirA protein in different agrobacterial hosts .
8809772	0	Ti	117,119	traR	104,108	Ti	traR	null	8541898(Tax:90371)	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Localization of OccR-activated and TraR-activated promoters that express two ABC-type permeases and the traR gene of Ti plasmid pTiR10 .
10438776	0	Ti	28,30	trb	39,42	Ti	trb	null	6957	Chemical	Gene	system|compound|START_ENTITY system|compound|END_ENTITY	Essential components of the Ti plasmid trb system , a type IV macromolecular transporter .
26403762	0	TiAl6_V4	51,59	RANKL	77,82	TiAl6 V4	RANKL	null	21943(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Expression of XBP1s in fibroblasts is critical for TiAl6_V4 particle-induced RANKL expression and osteolysis .
22349003	0	TiC	0,3	myoglobin	78,87	TiC	myoglobin	null	4151	Chemical	Gene	START_ENTITY|nmod|transfer transfer|nmod|END_ENTITY	TiC nanoparticles-chitosan composite film for the direct electron transfer of myoglobin and its application in biosensing .
21648466	0	TiO2	40,44	CO2	33,36	TiO2	CO2	CHEBI:32234	717	Chemical	Gene	dissociation|nmod|START_ENTITY dissociation|nmod|END_ENTITY	Electron-induced dissociation of CO2 on TiO2 -LRB- 110 -RRB- .
19653662	0	TiO2	34,38	HER2	10,14	TiO2	HER2	CHEBI:32234	2064	Chemical	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	Detecting HER2 on cancer cells by TiO2 spheres Mie scattering .
15312729	0	TiO2	45,49	TNT	26,29	TiO2	TNT	CHEBI:32234	162083	Chemical	Gene	degradation|nmod|START_ENTITY degradation|compound|END_ENTITY	Kinetics and mechanism of TNT degradation in TiO2 photocatalysis .
7575636	0	Tiamulin	0,8	CYP3A4	24,30	Tiamulin	CYP3A4	MESH:C014224	1576	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	Tiamulin inhibits human CYP3A4 activity in an NIH/3T3 cell line stably expressing CYP3A4 cDNA .
17368617	0	Tianeptine	0,10	brain-derived_neurotrophic_factor	21,54	Tianeptine	brain-derived neurotrophic factor	MESH:C050504	24225(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Tianeptine increases brain-derived_neurotrophic_factor expression in the rat amygdala .
16781141	0	Tibolone	0,8	prolactin	32,41	Tibolone	prolactin	MESH:C027385	5617	Chemical	Gene	production|amod|START_ENTITY production|amod|END_ENTITY	Tibolone and metabolites induce prolactin production in human endometrial stromal cells in vitro : evidence for cell-specific metabolism .
25180024	0	Ticlopidine	0,11	NTPDase1	66,74	Ticlopidine	NTPDase1	MESH:D013988	953	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Ticlopidine in its prodrug form is a selective inhibitor of human NTPDase1 .
2042443	0	Ticlopidine	0,11	fibrinogen	26,36	Ticlopidine	fibrinogen	MESH:D013988	2244	Chemical	Gene	lowers|nsubj|START_ENTITY lowers|dobj|END_ENTITY	Ticlopidine lowers plasma fibrinogen in patients with polycythaemia_rubra_vera and additional thrombotic risk factors .
11858494	0	Ticlopidine	0,11	thrombopoietin	50,64	Ticlopidine	thrombopoietin	MESH:D013988	21832(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|effects effects|nmod|END_ENTITY	Ticlopidine inhibits the prothrombotic effects of thrombopoietin and ameliorates survival after supralethal total body irradiation .
11041503	0	Tilmicosin	0,10	interleukin-8	28,41	Tilmicosin	interleukin-8	MESH:C052319	280828(Tax:9913)	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|expression expression|amod|END_ENTITY	Tilmicosin does not inhibit interleukin-8 gene expression in the bovine lung experimentally infected with Mannheimia -LRB- Pasteurella -RRB- _ haemolytica .
9581864	0	Tiludronate	0,11	interleukin-6	21,34	Tiludronate	interleukin-6	MESH:C058651	16193(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|synthesis synthesis|amod|END_ENTITY	Tiludronate inhibits interleukin-6 synthesis in osteoblasts : inhibition of phospholipase D activation in MC3T3-E1 cells .
12195603	0	Tiotropium	0,10	COPD	69,73	Tiotropium	COPD	MESH:C079890	260431	Chemical	Gene	START_ENTITY|dep|replacement replacement|nmod|ipratropium ipratropium|nmod|patients patients|nmod|END_ENTITY	Tiotropium : a potential replacement for ipratropium in patients with COPD .
15323298	0	Tiotropium	0,10	COPD	59,63	Tiotropium	COPD	MESH:C079890	260431	Chemical	Gene	START_ENTITY|dep|agent agent|nmod|management management|nmod|END_ENTITY	Tiotropium : a new , long-acting agent for the management of COPD -- a clinical review .
20037679	0	Tiotropium	0,10	COPD	42,46	Tiotropium	COPD	MESH:C079890	260431	Chemical	Gene	HandiHaler|compound|START_ENTITY HandiHaler|nmod|treatment treatment|nmod|END_ENTITY	Tiotropium HandiHaler in the treatment of COPD : a safety review .
20843311	0	Tiotropium	0,10	COPD	53,57	Tiotropium	COPD	MESH:C079890	260431	Chemical	Gene	cost-effectiveness|nmod:poss|START_ENTITY cost-effectiveness|nmod|treatment treatment|nmod|END_ENTITY	Tiotropium 's cost-effectiveness for the treatment of COPD : a cost-utility analysis under real-world conditions .
21503263	0	Tiotropium	24,34	COPD	91,95	Tiotropium	COPD	MESH:C079890	260431	Chemical	Gene	Impact|nmod|START_ENTITY Assessing|dobj|Impact Assessing|nmod|Patients Patients|compound|END_ENTITY	Assessing the Impact of Tiotropium on Lung Function and Physical Activity in GOLD Stage II COPD Patients who are Na ve to Maintenance Respiratory Therapy : A Study Protocol .
22836613	0	Tiotropium	0,10	CREB	41,45	Tiotropium	CREB	MESH:C079890	1385	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Tiotropium increases PPARy and decreases CREB in cells isolated from induced sputum of COPD patients .
15214776	0	Tiplaxtinin	0,11	plasminogen_activator_inhibitor-1	54,87	Tiplaxtinin	plasminogen activator inhibitor-1	MESH:C488103	5054	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Tiplaxtinin , a novel , orally efficacious inhibitor of plasminogen_activator_inhibitor-1 : design , synthesis , and preclinical characterization .
20346879	0	Tl-201	54,60	glucose_6-phosphate_dehydrogenase	82,115	Tl-201	glucose 6-phosphate dehydrogenase	null	2539	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	The effects of chemical and radioactive properties of Tl-201 on human erythrocyte glucose_6-phosphate_dehydrogenase activity .
16752227	0	Tn	159,161	MUC1	146,150	Tn	MUC1	null	4582	Chemical	Gene	antigen|compound|START_ENTITY antigen|compound|END_ENTITY	Expression of Vicia villosa agglutinin -LRB- VVA -RRB- - binding glycoprotein in primary breast_cancer cells in relation to lymphatic metastasis : is atypical MUC1 bearing Tn antigen a receptor of VVA ?
16140958	0	Tn	104,106	MUC6	96,100	Tn	MUC6	null	4588	Chemical	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Molecular basis of incomplete O-glycan synthesis in MCF-7 breast_cancer cells : putative role of MUC6 in Tn antigen expression .
7867956	0	Tn1546	17,23	vanZ	4,8	Tn1546	vanZ	null	4783138(Tax:1352)	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	The vanZ gene of Tn1546 from Enterococcus_faecium_BM4147 confers resistance to teicoplanin .
2553542	0	Tn4001	123,129	IS256	32,37	Tn4001	IS256	null	17363256	Chemical	Gene	analysis|nmod|START_ENTITY analysis|nmod|END_ENTITY	Nucleotide sequence analysis of IS256 from the Staphylococcus_aureus gentamicin-tobramycin-kanamycin-resistance transposon Tn4001 .
15923090	0	Tn4555	56,62	TnpA	79,83	Tn4555	TnpA	null	14014257	Chemical	Gene	Analysis|nmod|START_ENTITY Analysis|nmod|END_ENTITY	Analysis of chromosomal insertion sites for Bacteroides Tn4555 and the role of TnpA .
24729783	0	Tocotrienol	53,64	PPAR_y	118,124	Tocotrienol	PPAR y	MESH:D024508	5468	Chemical	Gene	Mediated|compound|START_ENTITY Mediated|nmod|END_ENTITY	Synergistic Antiproliferative Effects of Combined y - Tocotrienol and PPAR_y Antagonist Treatment Are Mediated through PPAR_y - Independent Mechanisms in Breast_Cancer Cells .
21723941	0	Tocotrienols	0,12	AKT	21,24	Tocotrienols	AKT	MESH:D024508	207	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|activation activation|compound|END_ENTITY	Tocotrienols inhibit AKT and ERK activation and suppress pancreatic_cancer cell proliferation by suppressing the ErbB2 pathway .
12788105	0	Tocotrienols	0,12	IKBKAP	20,26	Tocotrienols	IKBKAP	MESH:D024508	8518	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Tocotrienols induce IKBKAP expression : a possible therapy for familial_dysautonomia .
12440523	0	Tocotrienols	0,12	glutathione_S-transferase_P1-1	27,57	Tocotrienols	glutathione S-transferase P1-1	MESH:D024508	2950	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|END_ENTITY	Tocotrienols inhibit human glutathione_S-transferase_P1-1 .
25525634	0	Tofogliflozin	0,13	SGLT2	34,39	Tofogliflozin	SGLT2	MESH:C575086	6524	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Tofogliflozin : a highly selective SGLT2 inhibitor for the treatment of type 2 diabetes .
26158794	0	Tofogliflozin	65,78	SGLT2	86,91	Tofogliflozin	SGLT2	MESH:C575086	6524	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|compound|END_ENTITY	A Pharmacokinetic/Pharmacodynamic Drug-Drug Interaction Study of Tofogliflozin -LRB- a New SGLT2 Inhibitor -RRB- and Selected Anti-Type 2 Diabetes_Mellitus Drugs .
23751087	0	Tofogliflozin	0,13	sodium-glucose_co-transporter_2	23,54	Tofogliflozin	sodium-glucose co-transporter 2	MESH:C575086	6524	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Tofogliflozin , a novel sodium-glucose_co-transporter_2 inhibitor , improves renal and pancreatic function in db/db mice .
10617079	0	Tokaramide_A	0,12	cathepsin_B	20,31	Tokaramide A	cathepsin B	MESH:C403246	1508	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Tokaramide_A , a new cathepsin_B inhibitor from the marine sponge Theonella aff .
16166536	0	TolB	16,20	colicin_E9	54,64	TolB	colicin E9	null	7377410(Tax:562)	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Interactions of TolB with the translocation domain of colicin_E9 require an extended TolB box .
16718685	0	Tolbutamide	0,11	connexin43	60,70	Tolbutamide	connexin43	MESH:D014044	2697	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|nmod|END_ENTITY	Tolbutamide reduces glioma cell proliferation by increasing connexin43 , which promotes the up-regulation of p21 and p27 and subsequent changes in retinoblastoma phosphorylation .
3065196	0	Tolbutamide	0,11	gastrin	21,28	Tolbutamide	gastrin	MESH:D014044	2520	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|compound|END_ENTITY	Tolbutamide inhibits gastrin release in man .
5624126	0	Tolbutamide	0,11	insulin	54,61	Tolbutamide	insulin	MESH:D014044	3630	Chemical	Gene	-RSB-|nsubj|START_ENTITY -RSB-|nmod|END_ENTITY	Tolbutamide and the incorporation of -LSB- 3H -RSB- leucine into insulin in vitro .
7854158	0	Tolbutamide	0,11	insulin	40,47	Tolbutamide	insulin	MESH:D014044	3630	Chemical	Gene	causes|nsubj|START_ENTITY causes|dobj|increase increase|nmod|secretion secretion|compound|END_ENTITY	Tolbutamide causes a modest increase in insulin secretion in cystic_fibrosis patients with impaired_glucose_tolerance .
6130015	0	Tolbutamide	0,11	somatostatin	31,43	Tolbutamide	somatostatin	MESH:D014044	24797(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|compound|END_ENTITY	Tolbutamide stimulates gastric somatostatin release from isolated perfused rat stomach .
21521027	0	Tolcapone	0,9	COMT	11,15	Tolcapone	COMT	MESH:C066340	1312	Chemical	Gene	START_ENTITY|appos|polymorphisms polymorphisms|amod|END_ENTITY	Tolcapone , COMT polymorphisms and pharmacogenomic treatment of schizophrenia .
9591515	0	Tolcapone	0,9	COMT	11,15	Tolcapone	COMT	MESH:C066340	1312	Chemical	Gene	START_ENTITY|dep|inhibition inhibition|amod|END_ENTITY	Tolcapone : COMT inhibition for the treatment of Parkinson 's _ disease .
9917075	0	Tolcapone	0,9	catechol-O-methyltransferase	23,51	Tolcapone	catechol-O-methyltransferase	MESH:C066340	1312	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Tolcapone , a selective catechol-O-methyltransferase inhibitor for treatment of Parkinson 's _ disease .
24462621	0	Tolfenamic_acid	0,15	BACE1	30,35	Tolfenamic acid	BACE1	MESH:C009500	23821(Tax:10090)	Chemical	Gene	downregulates|amod|START_ENTITY END_ENTITY|nsubj|downregulates	Tolfenamic_acid downregulates BACE1 and protects against lead-induced upregulation of Alzheimer 's _ disease related biomarkers .
17618427	0	Tolfenamic_acid	0,15	CYP1A2	28,34	Tolfenamic acid	CYP1A2	MESH:C009500	1544	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|compound|END_ENTITY	Tolfenamic_acid is a potent CYP1A2 inhibitor in vitro but does not interact in vivo : correction for protein binding is needed for data interpretation .
27089389	0	Tolfenamic_acid	0,15	b-catenin	30,39	Tolfenamic acid	b-catenin	MESH:C009500	1499	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	Tolfenamic_acid downregulates b-catenin in colon_cancer .
14964621	0	Toluene	0,7	p75NTR	15,21	Toluene	p75NTR	MESH:D014050	24596(Tax:10116)	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|expression expression|amod|END_ENTITY	Toluene alters p75NTR expression in the rat brainstem .
18250044	0	Toluene_diisocyanate	1,21	vascular_endothelial_growth_factor	32,66	Toluene diisocyanate	vascular endothelial growth factor	MESH:D014051	7422	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	-LSB- Toluene_diisocyanate increases vascular_endothelial_growth_factor expression in human bronchial epithelial cells -RSB- .
26742881	0	Tolvaptan	0,9	Vasopressin	35,46	Tolvaptan	Vasopressin	MESH:C116664	551	Chemical	Gene	START_ENTITY|xcomp|Blockage Blockage|nmod|Receptor Receptor|compound|END_ENTITY	Tolvaptan Prolongs Blockage of the Vasopressin Type II Receptor Over 24 Hours in Responders With Stage D Heart_Failure .
22027579	0	Tolvaptan	0,9	vasopressin	19,30	Tolvaptan	vasopressin	MESH:C116664	551	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Tolvaptan , an oral vasopressin antagonist , in the treatment of hyponatremia in cirrhosis .
18544347	0	Tomatidine	0,10	iNOS	20,24	Tomatidine	iNOS	MESH:C003677	18126(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Tomatidine inhibits iNOS and COX-2 through suppression of NF-kappaB and JNK pathways in LPS-stimulated mouse macrophages .
26164718	0	Tongxinluo	0,10	nNOS	19,23	Tongxinluo	nNOS	MESH:C513941	24598(Tax:10116)	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Tongxinluo Induces nNOS Expression Through ERK Activation : Possible Contribution to the Effects of Tongxinluo to Attenuate Vasoconstriction .
26164718	0	Tongxinluo	99,109	nNOS	19,23	Tongxinluo	nNOS	MESH:C513941	24598(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Contribution|dep|Effects Expression|parataxis|Contribution Expression|compound|END_ENTITY	Tongxinluo Induces nNOS Expression Through ERK Activation : Possible Contribution to the Effects of Tongxinluo to Attenuate Vasoconstriction .
27029427	0	Topiroxostat	64,76	xanthine_oxidoreductase	29,52	Topiroxostat	xanthine oxidoreductase	MESH:C504882	22436(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Renoprotective effect of the xanthine_oxidoreductase inhibitor , Topiroxostat , on Adenine-Induced Renal_Injury .
19164467	0	Torcetrapib	0,11	cholesteryl_ester_transfer_protein	120,154	Torcetrapib	cholesteryl ester transfer protein	MESH:C483909	1071	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|mechanism mechanism|nmod|inhibition inhibition|compound|END_ENTITY	Torcetrapib induces aldosterone and cortisol production by an intracellular calcium-mediated mechanism independently of cholesteryl_ester_transfer_protein inhibition .
20051879	0	Torcetrapib	0,11	cholesteryl_ester_transfer_protein	60,94	Torcetrapib	cholesteryl ester transfer protein	MESH:C483909	100327267(Tax:9986)	Chemical	Gene	produces|nsubj|START_ENTITY produces|dobj|endothelial_dysfunction endothelial_dysfunction|nmod|inhibition inhibition|compound|END_ENTITY	Torcetrapib produces endothelial_dysfunction independent of cholesteryl_ester_transfer_protein inhibition .
10632979	0	Toremifene	0,10	ICAM-1	74,80	Toremifene	ICAM-1	MESH:D017312	3383	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Toremifene increases the expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- on MCF-7_breast_cancer cells and Jurkat cells .
25317836	0	Tormentic_Acid	0,14	Glucose_Transporter_4	142,163	Tormentic Acid	Glucose Transporter 4	MESH:C007695	20528(Tax:10090)	Chemical	Gene	Suppresses|nsubj|START_ENTITY Suppresses|nmod|END_ENTITY	Tormentic_Acid , a Major Component of Suspension Cells of Eriobotrya japonica , Suppresses High-Fat Diet-Induced Diabetes and Hyperlipidemia by Glucose_Transporter_4 and AMP-Activated Protein Kinase Phosphorylation .
9415036	0	Tosylphenylalanine_chloromethyl_ketone	0,38	TNF-alpha	48,57	Tosylphenylalanine chloromethyl ketone	TNF-alpha	null	21926(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|synthesis synthesis|amod|END_ENTITY	Tosylphenylalanine_chloromethyl_ketone inhibits TNF-alpha mRNA synthesis in the presence of activated NF-kappa_B in RAW 264.7 macrophages .
16633714	0	Trabectedin	0,11	P-glycoprotein	50,64	Trabectedin	P-glycoprotein	MESH:C099150	5243	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Trabectedin -LRB- ET-743 , Yondelis -RRB- is a substrate for P-glycoprotein , but only high expression of P-glycoprotein confers the multidrug resistance phenotype .
22428763	0	Tramadol	0,8	CYP2D6	69,75	Tramadol	CYP2D6	MESH:D014147	1565	Chemical	Gene	efficacy|amod|START_ENTITY efficacy|nmod|patients patients|nmod|postoperative_pain postoperative_pain|nmod|relation relation|nmod|END_ENTITY	Tramadol efficacy in patients with postoperative_pain in relation to CYP2D6 and MDR1 polymorphisms .
23567787	0	Tramadol	58,66	CYP2D6	0,6	Tramadol	CYP2D6	MESH:D014147	1565	Chemical	Gene	Therapy|compound|START_ENTITY Predictor|nmod|Therapy *|dobj|Predictor *|nsubj|END_ENTITY	CYP2D6 * 2 Polymorphism as a Predictor of Failed Outpatient Tramadol Therapy in Postherpetic_Neuralgia Patients .
26209290	0	Tramadol	53,61	CYP2D6	167,173	Tramadol	CYP2D6	MESH:D014147	1565	Chemical	Gene	Life|compound|START_ENTITY Predictions|nmod|Life Predictions|dep|Analysis Analysis|nmod|Contributors Contributors|nmod|Emphasis Emphasis|nmod|Maturation Maturation|compound|END_ENTITY	Physiologically Based Pharmacokinetic Predictions of Tramadol Exposure Throughout Pediatric Life : an Analysis of the Different Clearance Contributors with Emphasis on CYP2D6 Maturation .
19693978	0	Tramadol	1,9	c-fos	19,24	Tramadol	c-fos	MESH:D014147	314322(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	-LSB- Tramadol inhibits c-fos expression in spinal cord dorsal horn and serum IL-6 levels induced by plantar_incision in rats -RSB- .
25706985	0	Trametinib	0,10	BRAF	42,46	Trametinib	BRAF	MESH:C560077	673	Chemical	Gene	START_ENTITY|nmod|Non-Small_Cell_Lung_Cancer Non-Small_Cell_Lung_Cancer|compound|END_ENTITY	Trametinib with or without Vemurafenib in BRAF Mutated Non-Small_Cell_Lung_Cancer .
23971497	0	Trametinib	0,10	MEK	34,37	Trametinib	MEK	MESH:C560077	5609	Chemical	Gene	inhibitor|advmod|START_ENTITY inhibitor|nsubj|END_ENTITY	Trametinib , a first-in-class oral MEK inhibitor mass balance study with limited enrollment of two male subjects with advanced_cancers .
25287827	0	Trametinib	47,57	MEK	31,34	Trametinib	MEK	MESH:C560077	5609	Chemical	Gene	inhibition|appos|START_ENTITY inhibition|compound|END_ENTITY	Combined BRAF -LRB- Dabrafenib -RRB- and MEK inhibition -LRB- Trametinib -RRB- in patients with BRAFV600-mutant melanoma experiencing progression with single-agent BRAF inhibitor .
25684183	0	Trametinib	0,10	MEK	20,23	Trametinib	MEK	MESH:C560077	5609	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Trametinib , a novel MEK kinase inhibitor , suppresses lipopolysaccharide-induced tumor_necrosis_factor _ -LRB- TNF -RRB- - a production and endotoxin shock .
26347206	0	Trametinib	0,10	MEK	14,17	Trametinib	MEK	MESH:C560077	5609	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Trametinib : a MEK inhibitor for management of metastatic_melanoma .
26347206	0	Trametinib	0,10	MEK	14,17	Trametinib	MEK	MESH:C560077	5609	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Trametinib : a MEK inhibitor for management of metastatic_melanoma .
7527096	0	Trandolapril	0,12	ACE	74,77	Trandolapril	ACE	MESH:C052035	24310(Tax:10116)	Chemical	Gene	dose-response|amod|START_ENTITY dose-response|dep|effects effects|nmod|activity activity|compound|END_ENTITY	Trandolapril dose-response in spontaneously hypertensive rats : effects on ACE activity , blood pressure , and cardiac_hypertrophy .
8677862	0	Trandolapril	74,86	Angiotensin-converting_enzyme	0,29	Trandolapril	Angiotensin-converting enzyme	MESH:C052035	1636	Chemical	Gene	Study|compound|START_ENTITY inhibition|dep|Study inhibition|amod|END_ENTITY	Angiotensin-converting_enzyme inhibition after myocardial_infarction : the Trandolapril Cardiac Evaluation Study .
12852701	0	Trandolapril	0,12	angiotensin-converting_enzyme	22,51	Trandolapril	angiotensin-converting enzyme	MESH:C052035	1636	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Trandolapril : a newer angiotensin-converting_enzyme inhibitor .
10100083	0	Trandolapril	165,177	angiotensin_converting_enzyme	34,63	Trandolapril	angiotensin converting enzyme	MESH:C052035	1636	Chemical	Gene	Study|compound|START_ENTITY study|dep|Study study|nmod|effect effect|nmod|inhibition inhibition|amod|END_ENTITY	Controlled study of the effect of angiotensin_converting_enzyme inhibition versus calcium-entry blockade on insulin sensitivity in overweight hypertensive patients : Trandolapril Italian Study -LRB- TRIS -RRB- .
21354136	0	Trans-Chalcone	0,14	VEGF	24,28	Trans-Chalcone	VEGF	CHEBI:48965	22339(Tax:10090)	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|dobj|expression expression|compound|END_ENTITY	Trans-Chalcone prevents VEGF expression and retinal_neovascularization in the ischemic retina .
19288033	0	Trans-Zeatin	0,12	matrix_metalloproteinase-1	34,60	Trans-Zeatin	matrix metalloproteinase-1	CHEBI:16522	4312	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Trans-Zeatin inhibits UVB-induced matrix_metalloproteinase-1 expression via MAP kinase signaling in human skin fibroblasts .
21679764	0	Trans-resveratrol	0,17	Smad2/3	46,53	Trans-resveratrol	Smad2/3	MESH:C059514	17126;17127	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Trans-resveratrol inhibits phosphorylation of Smad2/3 and represses FSHb gene expression by a SirT1-independent pathway in LbT2 gonadotrope cells .
20978530	0	Trans_fatty_acids	0,17	insulin	19,26	Trans fatty acids	insulin	MESH:D044242	3630	Chemical	Gene	START_ENTITY|appos|resistance resistance|compound|END_ENTITY	Trans_fatty_acids , insulin resistance and diabetes .
18956254	0	Transcobalamin	0,14	TC	16,18	Transcobalamin	TC	null	6948	Chemical	Gene	deficiency|amod|START_ENTITY deficiency|appos|END_ENTITY	Transcobalamin -LRB- TC -RRB- deficiency -- potential cause of bone_marrow_failure in childhood .
1280287	0	Transdermal_17_beta-estradiol	0,29	insulin-like_growth_factor-I	88,116	Transdermal 17 beta-estradiol	insulin-like growth factor-I	null	3479	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|nmod|END_ENTITY	Transdermal_17_beta-estradiol combined with oral progestogen increases plasma levels of insulin-like_growth_factor-I in postmenopausal women .
25252112	0	Transition_Metal	59,75	NHC	76,79	Transition Metal	NHC	CHEBI:27081	10473	Chemical	Gene	Complexes|compound|START_ENTITY Complexes|compound|END_ENTITY	Direct Catalytic Addition of Alkylnitriles to Aldehydes by Transition_Metal / NHC Complexes .
26252078	0	Transition_State	22,38	IRAP	62,66	Transition State	IRAP	null	4012	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|nmod|END_ENTITY	Virtual Screening for Transition_State Analogue Inhibitors of IRAP Based on Quantum Mechanically Derived Reaction Coordinates .
27019223	0	Transition_State	0,16	Rv0091	45,51	Transition State	Rv0091	null	886953(Tax:83332)	Chemical	Gene	Structure|compound|START_ENTITY Structure|nmod|END_ENTITY	Transition_State Structure and Inhibition of Rv0091 , a 5 ' - Deoxyadenosine/5 ' - methylthioadenosine Nucleosidase from Mycobacterium_tuberculosis .
25825494	0	Transition_Zone	41,56	Kinesin-2	15,24	Transition Zone	Kinesin-2	null	16563(Tax:10090)	Chemical	Gene	Formation|compound|START_ENTITY Mediates|dobj|Formation Mediates|nsubj|END_ENTITY	Heterotrimeric Kinesin-2 -LRB- KIF3 -RRB- Mediates Transition_Zone and Axoneme Formation of Mouse Photoreceptors .
26982032	0	Transition_Zone	58,73	MKS5	0,4	Transition Zone	MKS5	null	23322	Chemical	Gene	Pathway|nmod|START_ENTITY Pathway|compound|END_ENTITY	MKS5 and CEP290 Dependent Assembly Pathway of the Ciliary Transition_Zone .
24364734	0	Transmembrane	0,13	amyloid_precursor_protein	37,62	Transmembrane	amyloid precursor protein	null	351	Chemical	Gene	structures|amod|START_ENTITY structures|nmod|END_ENTITY	Transmembrane fragment structures of amyloid_precursor_protein depend on membrane surface curvature .
19689925	0	Transmembrane	0,13	heparin-binding_epidermal_growth_factor-like_growth_factor	38,96	Transmembrane	heparin-binding epidermal growth factor-like growth factor	null	1839	Chemical	Gene	isoforms|amod|START_ENTITY isoforms|nmod|END_ENTITY	Transmembrane and soluble isoforms of heparin-binding_epidermal_growth_factor-like_growth_factor regulate distinct processes in the pancreas .
25921737	0	Transmembrane_AMPA	46,64	TARP	94,98	Transmembrane AMPA	TARP	null	94242(Tax:10090)	Chemical	Gene	Protein|compound|START_ENTITY Protein|appos|END_ENTITY	Inquiries into the Biological Significance of Transmembrane_AMPA Receptor Regulatory Protein -LRB- TARP -RRB- y-8 Through Investigations of TARP y-8 Null Mice .
27062244	0	Tranylcypromine	0,15	LSD1	50,54	Tranylcypromine	LSD1	MESH:D014191	99982(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|appos|END_ENTITY	Tranylcypromine , a lysine-specific_demethylase_1 -LRB- LSD1 -RRB- inhibitor , suppresses lesion growth and improves generalized hyperalgesia in mouse with induced endometriosis .
27062244	0	Tranylcypromine	0,15	lysine-specific_demethylase_1	19,48	Tranylcypromine	lysine-specific demethylase 1	MESH:D014191	99982(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Tranylcypromine , a lysine-specific_demethylase_1 -LRB- LSD1 -RRB- inhibitor , suppresses lesion growth and improves generalized hyperalgesia in mouse with induced endometriosis .
15182726	0	Trapidil	0,8	CD40	27,31	Trapidil	CD40	MESH:D014192	958	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Trapidil inhibits monocyte CD40 expression by preventing IFN-gamma-induced STAT1 S727 phosphorylation .
23928189	0	Trapidil	0,8	NFATc1	102,108	Trapidil	NFATc1	MESH:D014192	18018(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Trapidil , a platelet-derived growth factor antagonist , inhibits osteoclastogenesis by down-regulating NFATc1 and suppresses bone_loss in mice .
10576207	0	Trapidil	0,8	monocyte_chemoattractant_protein-1	18,52	Trapidil	monocyte chemoattractant protein-1	MESH:D014192	100009130(Tax:9986)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|accumulation accumulation|amod|END_ENTITY	Trapidil inhibits monocyte_chemoattractant_protein-1 and macrophage accumulation after balloon_arterial_injury in rabbits .
3983468	0	Trazodone	0,9	adenosine_deaminase	61,80	Trazodone	adenosine deaminase	MESH:D014196	24165(Tax:10116)	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Trazodone , a nontricyclic antidepressant , is an inhibitor of adenosine_deaminase .
536185	0	Trazodone	0,9	prolactin	48,57	Trazodone	prolactin	MESH:D014196	5617	Chemical	Gene	START_ENTITY|dobj|levels levels|compound|END_ENTITY	Trazodone intravenously administered and plasma prolactin levels .
7673654	0	Trazodone	0,9	prolactin	37,46	Trazodone	prolactin	MESH:D014196	5617	Chemical	Gene	treatment|amod|START_ENTITY increases|nsubj|treatment increases|dobj|concentrations concentrations|compound|END_ENTITY	Trazodone treatment increases plasma prolactin concentrations in depressed patients .
12080443	0	Trecadrine	11,21	leptin	54,60	Trecadrine	leptin	MESH:C101319	25608(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|metabolism metabolism|amod|END_ENTITY	Effects of Trecadrine , a beta3-adrenergic agonist , on leptin secretion , glucose and lipid metabolism in isolated rat adipocytes .
25841320	0	Trehalose	0,9	SOD1	27,31	Trehalose	SOD1	MESH:D014199	20655(Tax:10090)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|compound|END_ENTITY	Trehalose decreases mutant SOD1 expression and alleviates_motor_deficiency in early but not end-stage amyotrophic_lateral_sclerosis in a SOD1-G93A mouse model .
19619606	0	Tri-iodothyronine	0,17	adiponutrin	30,41	Tri-iodothyronine	adiponutrin	MESH:D014284	362972(Tax:10116)	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	Tri-iodothyronine upregulates adiponutrin mRNA expression in rat and human adipocytes .
26805879	0	Triacylglycerol	39,54	Nut	12,15	Triacylglycerol	Nut	MESH:D014280	213765(Tax:10090)	Chemical	Gene	Accumulation|compound|START_ENTITY Accumulation|compound|END_ENTITY	Korean_Pine Nut Oil Attenuated Hepatic Triacylglycerol Accumulation in High-Fat Diet-Induced Obese Mice .
22233193	0	Triacylglycerol	0,15	PDAT1	29,34	Triacylglycerol	PDAT1	MESH:D014280	831208(Tax:3702)	Chemical	Gene	synthesis|amod|START_ENTITY synthesis|nmod|END_ENTITY	Triacylglycerol synthesis by PDAT1 in the absence of DGAT1 activity is dependent on re-acylation of LPC by LPCAT2 .
7074125	0	Triacylglycerol	0,15	lipase	16,22	Triacylglycerol	lipase	MESH:D014280	291437(Tax:10116)	Chemical	Gene	activities|amod|START_ENTITY activities|amod|END_ENTITY	Triacylglycerol lipase , monoacylglycerol_lipase and phospholipase activities of highly purified rat hepatic_lipase .
17434742	0	Triamcinolone	0,13	VEGF	128,132	Triamcinolone	VEGF	MESH:D014221	83785(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|retinal_vascular_pathology retinal_vascular_pathology|nmod|interruption interruption|nmod|activation activation|nmod|END_ENTITY	Triamcinolone suppresses retinal_vascular_pathology via a potent interruption of proinflammatory signal-regulated activation of VEGF during a relative hypoxia .
12174062	0	Triamcinolone	0,13	bFGF	25,29	Triamcinolone	bFGF	MESH:D014221	2247	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|compound|END_ENTITY	Triamcinolone stimulates bFGF production and inhibits TGF-beta1 production by human dermal fibroblasts .
16049703	0	Triamcinolone_acetonide	0,23	vascular_endothelial_growth_factor	75,109	Triamcinolone acetonide	vascular endothelial growth factor	MESH:D014222	83785(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|expression expression|compound|END_ENTITY	Triamcinolone_acetonide suppresses interleukin-1_beta-mediated increase in vascular_endothelial_growth_factor expression in cultured rat M ller cells .
19375913	0	Triazinediones	0,14	prokineticin_1	18,32	Triazinediones	prokineticin 1	null	192205(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|antagonists antagonists|amod|END_ENTITY	Triazinediones as prokineticin_1 receptor antagonists .
25504761	0	Triazinones	52,63	BACE-1	67,73	Triazinones	BACE-1	null	23821(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|Inhibitors Inhibitors|amod|END_ENTITY	Multitarget Drug Discovery for Alzheimer 's _ Disease : Triazinones as BACE-1 and GSK-3b Inhibitors .
26731630	0	Triazole	73,81	Acetylcholinesterase	110,130	Triazole	Acetylcholinesterase	CHEBI:38597	43	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|nmod|END_ENTITY	Steric and Dynamic Parameters Influencing In Situ Cycloadditions to Form Triazole Inhibitors with Crystalline Acetylcholinesterase .
25328661	0	Triazole	0,8	Hsp90	54,59	Triazole	Hsp90	CHEBI:38597	3320	Chemical	Gene	START_ENTITY|nmod|Inhibitors Inhibitors|compound|END_ENTITY	Triazole Containing Novobiocin and Biphenyl_Amides as Hsp90 C-Terminal Inhibitors .
26551065	0	Triazole	0,8	eosinophil_derived_neurotoxin	56,85	Triazole	eosinophil derived neurotoxin	CHEBI:38597	6036	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Triazole double-headed ribonucleosides as inhibitors of eosinophil_derived_neurotoxin .
18778939	0	Triazole	0,8	oxytocin	9,17	Triazole	oxytocin	CHEBI:38597	5020	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|compound|END_ENTITY	Triazole oxytocin antagonists : identification of aryl_ether replacements for a biaryl substituent .
19963374	0	Triazole	0,8	oxytocin	9,17	Triazole	oxytocin	CHEBI:38597	5020	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|compound|END_ENTITY	Triazole oxytocin antagonists : Identification of an aryloxyazetidine replacement for a biaryl substituent .
7799397	0	Triazolinone_biphenylsulfonamides	0,33	angiotensin_II	37,51	Triazolinone biphenylsulfonamides	angiotensin II	null	24179(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|antagonists antagonists|amod|END_ENTITY	Triazolinone_biphenylsulfonamides as angiotensin_II receptor antagonists with high affinity for both the AT1 and AT2 subtypes .
26677404	0	Triazolo	0,8	PDE10A	38,44	Triazolo	PDE10A	D014229	10846	Chemical	Gene	Derivatives|compound|START_ENTITY Derivatives|nmod|END_ENTITY	Triazolo Derivatives as Inhibitors of PDE10A .
25134932	0	Triazolo-thiadiazoles	19,40	TNF-alpha	58,67	Triazolo-thiadiazoles	TNF-alpha	null	7124	Chemical	Gene	START_ENTITY|nmod|Inhibitors Inhibitors|nmod|END_ENTITY	Discovery of Fused Triazolo-thiadiazoles as Inhibitors of TNF-alpha : Pharmacophore Hybridization for Treatment of Neuropathic_Pain .
25369270	0	Triazolopyridines	0,17	JAK1	31,35	Triazolopyridines	JAK1	CHEBI:46746	3716	Chemical	Gene	START_ENTITY|nmod|Inhibitors Inhibitors|compound|END_ENTITY	Triazolopyridines as Selective JAK1 Inhibitors : From Hit Identification to GLPG0634 .
21602043	0	Triazoloquinazolines	0,20	phosphodiesterase_10A	41,62	Triazoloquinazolines	phosphodiesterase 10A	null	10846	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Triazoloquinazolines as a novel class of phosphodiesterase_10A -LRB- PDE10A -RRB- inhibitors .
21432313	0	Tributyltin	0,11	TNFa	28,32	Tributyltin	TNFa	MESH:C011559	21926(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Tributyltin -LRB- TBT -RRB- increases TNFa mRNA expression and induces apoptosis in the murine macrophage cell line in vitro .
22449404	0	Tributyltin	0,11	glutathione_S-transferase	71,96	Tributyltin	glutathione S-transferase	MESH:C011559	58962(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|inhibiting inhibiting|dobj|END_ENTITY	Tributyltin induces oxidative stress and neuronal_injury by inhibiting glutathione_S-transferase in rat organotypic hippocampal slice cultures .
25382723	0	Tributyltin	0,11	interleukin_1_beta	32,50	Tributyltin	interleukin 1 beta	MESH:C011559	3553	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|secretion secretion|nmod|END_ENTITY	Tributyltin alters secretion of interleukin_1_beta from human immune cells .
21778681	0	Tributyltin	0,11	osteocalcin	19,30	Tributyltin	osteocalcin	MESH:C011559	12097(Tax:10090)	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|expression expression|compound|END_ENTITY	Tributyltin alters osteocalcin , matrix_metalloproteinase_20 and dentin_sialophosphoprotein gene expression in mineralizing mouse embryonic tooth in vitro .
21219878	0	Tributyltin_chloride	0,20	ABCA1	29,34	Tributyltin chloride	ABCA1	MESH:C011559	11303(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Tributyltin_chloride induces ABCA1 expression and apolipoprotein_A-I-mediated cellular cholesterol efflux by activating LXRa/RXR .
24055800	0	Tributyltin_chloride	0,20	JNK	52,55	Tributyltin chloride	JNK	MESH:C011559	5599	Chemical	Gene	induced|nsubj|START_ENTITY induced|nmod|END_ENTITY	Tributyltin_chloride induced testicular toxicity by JNK and p38 activation , redox imbalance and cell death in sertoli-germ cell co-culture .
11485828	0	Tributyrin	0,10	caspase-3	83,92	Tributyrin	caspase-3	MESH:C005830	836	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Tributyrin , an oral butyrate analogue , induces apoptosis through the activation of caspase-3 .
8494503	0	Trichloroethylene	0,17	N-acetyl-beta-D-glucosaminidase	77,108	Trichloroethylene	N-acetyl-beta-D-glucosaminidase	MESH:D014241	10724	Chemical	Gene	exposure|amod|START_ENTITY exposure|nmod|END_ENTITY	Trichloroethylene exposure in vapour degreasing and the urinary excretion of N-acetyl-beta-D-glucosaminidase .
12657742	0	Trichloroethylene	0,17	endothelial_nitric_oxide_synthase	68,101	Trichloroethylene	endothelial nitric oxide synthase	MESH:D014241	4846	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|nmod|END_ENTITY	Trichloroethylene decreases heat_shock_protein_90 interactions with endothelial_nitric_oxide_synthase : implications for endothelial cell proliferation .
21305388	0	Trichostatin	0,12	Th1	38,41	Trichostatin	Th1	CHEBI:39146	57314(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Trichostatin differentially regulates Th1 and Th2 responses and alleviates rheumatoid_arthritis in mice .
12684681	0	Trichostatin	0,12	p27	110,113	Trichostatin	p27	CHEBI:39146	10671	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Trichostatin inhibits the growth of ACHN renal_cell_carcinoma cells via cell cycle arrest in association with p27 , or apoptosis .
21883892	0	Trichostatin_A	0,14	5-lipoxygenase	23,37	Trichostatin A	5-lipoxygenase	MESH:C012589	240	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|activity activity|amod|END_ENTITY	Trichostatin_A induces 5-lipoxygenase promoter activity and mRNA expression via inhibition of histone_deacetylase_2_and_3 .
20925046	0	Trichostatin_A	0,14	Apaf-1	24,30	Trichostatin A	Apaf-1	MESH:C012589	317	Chemical	Gene	restores|nsubj|START_ENTITY restores|dobj|function function|compound|END_ENTITY	Trichostatin_A restores Apaf-1 function in chemoresistant ovarian_cancer cells .
19426671	0	Trichostatin_A	0,14	EGFR	128,132	Trichostatin A	EGFR	MESH:C012589	1956	Chemical	Gene	sensitizes|nsubj|START_ENTITY sensitizes|nmod|down-regulation down-regulation|nmod|c-FLIPL c-FLIPL|nmod|inhibition inhibition|nmod|pathway pathway|amod|END_ENTITY	Trichostatin_A sensitizes human ovarian_cancer cells to TRAIL-induced apoptosis by down-regulation of c-FLIPL via inhibition of EGFR pathway .
24707474	0	Trichostatin_A	0,14	EGFR	26,30	Trichostatin A	EGFR	MESH:C012589	1956	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Trichostatin_A suppresses EGFR expression through induction of microRNA-7 in an HDAC-independent manner in lapatinib-treated cells .
12200149	0	Trichostatin_A	0,14	IGFBP-3	63,70	Trichostatin A	IGFBP-3	MESH:C012589	3486	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|promoter promoter|compound|END_ENTITY	Trichostatin_A , a histone deacetylase inhibitor , activates the IGFBP-3 promoter by upregulating Sp1 activity in hepatoma cells : alteration of the Sp1/Sp3/HDAC1 multiprotein complex .
18097580	0	Trichostatin_A	116,130	histone_deacetylase	85,104	Trichostatin A	histone deacetylase	MESH:C012589	9734	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Cell cycle arrest and lytic induction of EBV-transformed B lymphoblastoid cells by a histone_deacetylase inhibitor , Trichostatin_A .
21520296	0	Trichostatin_A	0,14	histone_deacetylase	18,37	Trichostatin A	histone deacetylase	MESH:C012589	9734	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Trichostatin_A , a histone_deacetylase inhibitor , suppresses JAK2/STAT3 signaling via inducing the promoter-associated histone acetylation of SOCS1 and SOCS3 in human colorectal_cancer cells .
14985105	0	Trichostatin_A	0,14	osteopontin	29,40	Trichostatin A	osteopontin	MESH:C012589	20750(Tax:10090)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|promoter promoter|amod|END_ENTITY	Trichostatin_A activates the osteopontin gene promoter through AP1 site .
15358560	0	Trichostatin_A	0,14	p18INK4c	25,33	Trichostatin A	p18INK4c	MESH:C012589	1031	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|gene gene|amod|END_ENTITY	Trichostatin_A activates p18INK4c gene : differential activation and cooperation with p19INK4d gene .
18566213	0	Trichostatin_A	0,14	p73	28,31	Trichostatin A	p73	MESH:C012589	7161	Chemical	Gene	up-regulates|compound|START_ENTITY END_ENTITY|nsubj|up-regulates	Trichostatin_A up-regulates p73 and induces Bax-dependent apoptosis in cisplatin-resistant ovarian_cancer cells .
19633316	0	Trichostatin_A	0,14	thioredoxin_1	102,115	Trichostatin A	thioredoxin 1	MESH:C012589	116484(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Trichostatin_A enhances proliferation and migration of vascular smooth muscle cells by downregulating thioredoxin_1 .
26254348	0	Triciribine_Phosphate_Monohydrate	0,33	AKT	38,41	Triciribine Phosphate Monohydrate	AKT	null	207	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|compound|END_ENTITY	Triciribine_Phosphate_Monohydrate , an AKT Inhibitor , Enhances Gemcitabine Activity in Pancreatic_Cancer Cells .
20158608	0	Triclosan	0,9	InhA	38,42	Triclosan	InhA	MESH:D014260	3623	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	Triclosan inhibition of mycobacterial InhA in Saccharomyces_cerevisiae : yeast mitochondria as a novel platform for in vivo antimycolate assays .
23368947	0	Triclosan	0,9	MMP-13	17,23	Triclosan	MMP-13	MESH:D014260	171052(Tax:10116)	Chemical	Gene	blocks|nsubj|START_ENTITY blocks|dobj|expression expression|compound|END_ENTITY	Triclosan blocks MMP-13 expression in hormone-stimulated osteoblasts .
17949329	0	Triclosan	0,9	tumor_necrosis_factor-alpha	61,88	Triclosan	tumor necrosis factor-alpha	MESH:D014260	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|amod|END_ENTITY	Triclosan inhibits uropathogenic Escherichia_coli-stimulated tumor_necrosis_factor-alpha secretion in T24 bladder cells in vitro .
9210403	0	Tridegin	0,8	factor_XIIIa	38,50	Tridegin	factor XIIIa	MESH:C106835	2162	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Tridegin , a new peptidic inhibitor of factor_XIIIa , from the blood-sucking leech Haementeria ghilianii .
1472031	0	Triflavin	0,9	GpIIIa	60,66	Triflavin	GpIIIa	MESH:C070025	3690	Chemical	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Triflavin , an RGD-containing antiplatelet peptide , binds to GpIIIa of ADP-stimulated platelets .
8736111	0	Trifluoperazine	0,15	CD69	42,46	Trifluoperazine	CD69	MESH:D014268	969	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|nmod|END_ENTITY	Trifluoperazine reduces the expression of CD69 in phytohemagglutinin-activated lymphocytes .
6357573	0	Trifluoperazine	0,15	angiotensin_II	59,73	Trifluoperazine	angiotensin II	MESH:D014268	24179(Tax:10116)	Chemical	Gene	antagonizes|nsubj|START_ENTITY antagonizes|nmod|END_ENTITY	Trifluoperazine antagonizes inhibition of renin release by angiotensin_II .
2110826	0	Trifluoperazine	0,15	calmodulin	41,51	Trifluoperazine	calmodulin	MESH:D014268	100352392(Tax:9986)	Chemical	Gene	START_ENTITY|xcomp|binding binding|xcomp|porcine porcine|dobj|END_ENTITY	Trifluoperazine binding to porcine brain calmodulin and skeletal muscle troponin_C .
6477566	0	Trifluoperazine	0,15	calmodulin	27,37	Trifluoperazine	calmodulin	MESH:D014268	808	Chemical	Gene	shift|dep|START_ENTITY shift|dep|binding binding|nmod|END_ENTITY	Trifluoperazine binding to calmodulin : a shift reagent 43CA NMR study .
26713109	0	Trifluoromethyl	41,56	p97	117,120	Trifluoromethyl	p97	CHEBI:50127	4241	Chemical	Gene	Study|nmod|START_ENTITY Study|nmod|END_ENTITY	Structure-Activity Study of Bioisosteric Trifluoromethyl and Pentafluorosulfanyl_Indole Inhibitors of the AAA ATPase p97 .
10021942	0	Trifluoromethyl_ketone	0,22	fatty_acid_amide_hydrolase	37,63	Trifluoromethyl ketone	fatty acid amide hydrolase	null	2166	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Trifluoromethyl_ketone inhibitors of fatty_acid_amide_hydrolase : a probe of structural and conformational features contributing to inhibition .
25900515	0	Trifluridine	82,94	Concentrative_Nucleoside_Transporter_1	15,53	Trifluridine	Concentrative Nucleoside Transporter 1	MESH:D014271	9154	Chemical	Gene	Absorption|nmod|START_ENTITY END_ENTITY|nmod|Absorption	Involvement of Concentrative_Nucleoside_Transporter_1 in Intestinal Absorption of Trifluridine Using Human Small Intestinal Epithelial Cells .
25679806	0	Triglyceride	36,48	DGAT1	82,87	Triglyceride	DGAT1	CHEBI:17855	13350(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|Expression Expression|compound|END_ENTITY	F3MB -LRB- PANDER -RRB- Decreases Mice Hepatic Triglyceride and Is Associated with Decreased DGAT1 Expression .
25855506	0	Triglyceride	16,28	HCBP6	0,5	Triglyceride	HCBP6	CHEBI:17855	65991	Chemical	Gene	Homeostasis|compound|START_ENTITY Homeostasis|compound|END_ENTITY	HCBP6 Modulates Triglyceride Homeostasis in Hepatocytes Via the SREBP1c/FASN Pathway .
2731489	0	Triglyceride	0,12	lipase	13,19	Triglyceride	lipase	CHEBI:17855	291437(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|activities activities|amod|END_ENTITY	Triglyceride lipase activities in rat liver .
1261585	0	Triglyceride	0,12	secretin	57,65	Triglyceride	secretin	CHEBI:17855	6343	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|dep|role role|nmod|END_ENTITY	Triglyceride metabolism in acute starvation : the role of secretin and glucagon .
25819087	0	Triglycerides	111,124	NTM	96,99	Triglycerides	NTM	MESH:D014280	50863	Chemical	Gene	Genes|nmod|START_ENTITY Genes|compound|END_ENTITY	Genome-Wide Linkage and Positional Association Analyses Identify Associations of Novel AFF3 and NTM Genes with Triglycerides : The GenSalt Study .
25174769	0	Triglycerides	0,13	insulin	55,62	Triglycerides	insulin	MESH:D014280	3630	Chemical	Gene	START_ENTITY|dep|indicator indicator|nmod|resistance resistance|compound|END_ENTITY	Triglycerides and glucose index : a useful indicator of insulin resistance .
1743614	0	Triiodothyronine	0,16	ATP-citrate_lyase	28,45	Triiodothyronine	ATP-citrate lyase	MESH:D014284	104112(Tax:10090)	Chemical	Gene	control|amod|START_ENTITY control|nmod|END_ENTITY	Triiodothyronine control of ATP-citrate_lyase and malic enzyme during differentiation of a murine preadipocyte cell line .
27094789	0	Triiodothyronine	0,16	HIF1A	30,35	Triiodothyronine	HIF1A	MESH:D014284	3091	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Triiodothyronine -LRB- T3 -RRB- induces HIF1A and TGFA expression in MCF7 cells by activating PI3K .
23147208	0	Triiodothyronine	0,16	PI3K	71,75	Triiodothyronine	PI3K	MESH:D014284	85243(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|activating activating|dobj|END_ENTITY	Triiodothyronine -LRB- T3 -RRB- induces proinsulin gene expression by activating PI3K : possible roles for GSK-3b and the transcriptional factor PDX-1 .
27094789	0	Triiodothyronine	0,16	PI3K	84,88	Triiodothyronine	PI3K	MESH:D014284	5295	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|activating activating|dobj|END_ENTITY	Triiodothyronine -LRB- T3 -RRB- induces HIF1A and TGFA expression in MCF7 cells by activating PI3K .
18345403	0	Triiodothyronine	0,16	Rankl	38,43	Triiodothyronine	Rankl	MESH:D014284	117516(Tax:10116)	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|amod|END_ENTITY	Triiodothyronine -LRB- T3 -RRB- does not induce Rankl expression in rat Ros 17/2 .8 cells .
22075692	0	Triiodothyronine	0,16	UCP-1	25,30	Triiodothyronine	UCP-1	MESH:D014284	7350	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Triiodothyronine induces UCP-1 expression and mitochondrial biogenesis in human adipocytes .
2981760	0	Triiodothyronine	0,16	angiotensin_converting_enzyme	33,62	Triiodothyronine	angiotensin converting enzyme	MESH:D014284	1636	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Triiodothyronine increases serum angiotensin_converting_enzyme .
2123790	0	Triiodothyronine	0,16	apolipoprotein_A-I	31,49	Triiodothyronine	apolipoprotein A-I	MESH:D014284	25081(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|synthesis synthesis|compound|END_ENTITY	Triiodothyronine increases rat apolipoprotein_A-I synthesis and alters high-density lipoprotein composition in vivo .
8706762	0	Triiodothyronine	0,16	beta_3-adrenoceptor	27,46	Triiodothyronine	beta 3-adrenoceptor	MESH:D014284	155	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Triiodothyronine regulates beta_3-adrenoceptor expression in 3T3-F442A differentiating adipocytes .
8836703	0	Triiodothyronine	0,16	beta_3-adrenoceptor	43,62	Triiodothyronine	beta 3-adrenoceptor	MESH:D014284	25645(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|density density|amod|END_ENTITY	Triiodothyronine and amiodarone effects on beta_3-adrenoceptor density and lipolytic response to the beta 3-adrenergic agonist BRL_37344 in rat white adipocytes .
22360852	0	Triiodothyronine	0,16	cystatin_C	28,38	Triiodothyronine	cystatin C	MESH:D014284	1471	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|amod|END_ENTITY	Triiodothyronine stimulates cystatin_C production in bone cells .
1725515	0	Triiodothyronine	0,16	growth_hormone	36,50	Triiodothyronine	growth hormone	MESH:D014284	378781(Tax:9031)	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Triiodothyronine -LRB- T3 -RRB- inhibition of growth_hormone secretion by chicken pituitary cells in vitro .
2128417	0	Triiodothyronine	0,16	growth_hormone	46,60	Triiodothyronine	growth hormone	MESH:D014284	2688	Chemical	Gene	administration|amod|START_ENTITY reduces|nsubj|administration reduces|dobj|levels levels|compound|END_ENTITY	Triiodothyronine administration reduces serum growth_hormone levels and growth_hormone responses to thyrotropin-releasing_hormone in patients with anorexia_nervosa .
2494101	0	Triiodothyronine	0,16	growth_hormone	106,120	Triiodothyronine	growth hormone	MESH:D014284	378781(Tax:9031)	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|secretion secretion|amod|END_ENTITY	Triiodothyronine inhibition of thyrotropin-releasing_hormone - and growth_hormone-releasing factor-induced growth_hormone secretion in anesthetized chickens .
266726	0	Triiodothyronine	0,16	growth_hormone	41,55	Triiodothyronine	growth hormone	MESH:D014284	81668(Tax:10116)	Chemical	Gene	stimulates|amod|START_ENTITY END_ENTITY|nsubj|stimulates	Triiodothyronine stimulates specifically growth_hormone mRNA in rat pituitary_tumor cells .
7028136	0	Triiodothyronine	0,16	growth_hormone	79,93	Triiodothyronine	growth hormone	MESH:D014284	14599(Tax:10090)	Chemical	Gene	exert|nsubj|START_ENTITY exert|nmod|binding binding|nmod|END_ENTITY	Triiodothyronine and growth_hormone exert an opposite effect on the binding of growth_hormone and insulin by hepatocytes from dwarf mouse .
8171058	0	Triiodothyronine	0,16	growth_hormone	25,39	Triiodothyronine	growth hormone	MESH:D014284	378781(Tax:9031)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|secretion secretion|amod|END_ENTITY	Triiodothyronine reduces growth_hormone secretion and pituitary growth_hormone mRNA in the chicken , in vivo and in vitro .
9492065	0	Triiodothyronine	0,16	interleukin-6	27,40	Triiodothyronine	interleukin-6	MESH:D014284	16193(Tax:10090)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|synthesis synthesis|amod|END_ENTITY	Triiodothyronine modulates interleukin-6 synthesis in osteoblasts : inhibitions in protein kinase A and C pathways .
24058635	0	Triiodothyronine	0,16	leptin	44,50	Triiodothyronine	leptin	MESH:D014284	16846(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|compound|END_ENTITY	Triiodothyronine increases mRNA and protein leptin levels in short time in 3T3-L1 adipocytes by PI3K pathway activation .
7784255	0	Triiodothyronine	0,16	somatostatin	27,39	Triiodothyronine	somatostatin	MESH:D014284	24797(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Triiodothyronine regulates somatostatin gene expression in cultured fetal rat cerebrocortical cells .
10465283	0	Triiodothyronine	0,16	thyrotropin-releasing_hormone	32,61	Triiodothyronine	thyrotropin-releasing hormone	MESH:D014284	25569(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|synthesis synthesis|amod|END_ENTITY	Triiodothyronine down-regulates thyrotropin-releasing_hormone -LRB- TRH -RRB- synthesis and decreases pTRH - -LRB- 160-169 -RRB- and insulin releases from fetal rat islets in culture .
2128417	0	Triiodothyronine	0,16	thyrotropin-releasing_hormone	100,129	Triiodothyronine	thyrotropin-releasing hormone	MESH:D014284	7200	Chemical	Gene	administration|amod|START_ENTITY reduces|nsubj|administration reduces|advcl|END_ENTITY	Triiodothyronine administration reduces serum growth_hormone levels and growth_hormone responses to thyrotropin-releasing_hormone in patients with anorexia_nervosa .
2494101	0	Triiodothyronine	0,16	thyrotropin-releasing_hormone	31,60	Triiodothyronine	thyrotropin-releasing hormone	MESH:D014284	414344(Tax:9031)	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|secretion secretion|amod|END_ENTITY	Triiodothyronine inhibition of thyrotropin-releasing_hormone - and growth_hormone-releasing factor-induced growth_hormone secretion in anesthetized chickens .
3139393	0	Triiodothyronine	0,16	thyrotropin-releasing_hormone	59,88	Triiodothyronine	thyrotropin-releasing hormone	MESH:D014284	25569(Tax:10116)	Chemical	Gene	exerts|nsubj|START_ENTITY exerts|dobj|regulation regulation|nmod|expression expression|amod|END_ENTITY	Triiodothyronine exerts direct cell-specific regulation of thyrotropin-releasing_hormone gene expression in the hypothalamic paraventricular nucleus .
20831980	0	Trilostane	0,10	androgen_receptor	90,107	Trilostane	androgen receptor	MESH:C009954	367	Chemical	Gene	has|nsubj|START_ENTITY has|dobj|activity activity|nmod|END_ENTITY	Trilostane , an inhibitor of 3b-hydroxysteroid dehydrogenase , has an agonistic activity on androgen_receptor in human prostate_cancer cells .
12719766	0	Trimetazidine	0,13	Ca2	38,41	Trimetazidine	Ca2	MESH:D014292	379772(Tax:8355)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|concentration concentration|compound|END_ENTITY	Trimetazidine reduces basal cytosolic Ca2 + concentration during hypoxia in single Xenopus skeletal myocytes .
9879636	0	Trimethadione	0,13	cytochrome_P450	40,55	Trimethadione	cytochrome P450	MESH:D014293	4051	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|nmod|END_ENTITY	Trimethadione metabolism by human liver cytochrome_P450 : evidence for the involvement of CYP2E1 .
23896474	0	Trimethoprim	0,12	dihydrofolate_reductase	27,50	Trimethoprim	dihydrofolate reductase	MESH:D014295	1719	Chemical	Gene	resistance|amod|START_ENTITY resistance|nmod|END_ENTITY	Trimethoprim resistance of dihydrofolate_reductase variants from clinical isolates of Pneumocystis jirovecii .
26158281	0	Trimethyl	63,72	Insulin	30,37	Trimethyl	Insulin	null	3630	Chemical	Gene	Nanoparticles|compound|START_ENTITY Delivery|nmod|Nanoparticles Delivery|nmod|END_ENTITY	Efficient Peroral Delivery of Insulin via Vitamin_B12 Modified Trimethyl Chitosan Nanoparticles .
26915108	0	Trimethyltin	0,12	Reelin	23,29	Trimethyltin	Reelin	MESH:C046488	24718(Tax:10116)	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Trimethyltin Modulates Reelin Expression and Endogenous Neurogenesis in the Hippocampus of Developing Rats .
21290413	0	Trimethyltin	0,12	caspase_3	47,56	Trimethyltin	caspase 3	MESH:C046488	12367(Tax:10090)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|pathway pathway|amod|END_ENTITY	Trimethyltin initially activates the caspase_8 / caspase_3 pathway for damaging the primary cultured cortical neurons derived from embryonic mice .
21290413	0	Trimethyltin	0,12	caspase_8	37,46	Trimethyltin	caspase 8	MESH:C046488	12370(Tax:10090)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|pathway pathway|amod|END_ENTITY	Trimethyltin initially activates the caspase_8 / caspase_3 pathway for damaging the primary cultured cortical neurons derived from embryonic mice .
2046642	0	Trimethyltin	0,12	choline_acetyltransferase	23,48	Trimethyltin	choline acetyltransferase	MESH:C046488	290567(Tax:10116)	Chemical	Gene	increases|compound|START_ENTITY END_ENTITY|nsubj|increases	Trimethyltin increases choline_acetyltransferase in rat hippocampus .
9218629	0	Trimethyltin	0,12	gelatinase_B	21,33	Trimethyltin	gelatinase B	MESH:C046488	81687(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Trimethyltin induces gelatinase_B and urokinase in rat brain .
9887340	0	Trinucleotide	0,13	cartilage_oligomeric_matrix_protein	41,76	Trinucleotide	cartilage oligomeric matrix protein	null	1311	Chemical	Gene	START_ENTITY|nmod|gene gene|amod|END_ENTITY	Trinucleotide expansion mutations in the cartilage_oligomeric_matrix_protein -LRB- COMP -RRB- gene .
11452032	0	Tripartite	0,10	Dna2	49,53	Tripartite	Dna2	null	856569(Tax:4932)	Chemical	Gene	structure|amod|START_ENTITY structure|nmod|END_ENTITY	Tripartite structure of Saccharomyces_cerevisiae Dna2 helicase/endonuclease .
10940301	0	Tripartite	0,10	Gln3p	25,30	Tripartite	Gln3p	null	856763(Tax:4932)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Tripartite regulation of Gln3p by TOR , Ure2p , and phosphatases .
19557803	0	Tripeptide	50,60	hPEPT1	74,80	Tripeptide	hPEPT1	CHEBI:47923	6564	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Discovery of ligands for the human intestinal Di - / Tripeptide transporter -LRB- hPEPT1 -RRB- using a QSAR-assisted virtual screening strategy .
23533709	0	Tripeptides	41,52	COX-2	56,61	Tripeptides	COX-2	CHEBI:47923	4513	Chemical	Gene	START_ENTITY|nmod|Inhibitors Inhibitors|compound|END_ENTITY	Design , Synthesis , and Evaluation of New Tripeptides as COX-2 Inhibitors .
10970849	0	Triphosphate	0,12	guanylate-binding_protein_1	26,53	Triphosphate	guanylate-binding protein 1	MESH:C005692	2633	Chemical	Gene	structure|amod|START_ENTITY structure|nmod|END_ENTITY	Triphosphate structure of guanylate-binding_protein_1 and implications for nucleotide binding and GTPase mechanism .
23516487	0	Tripolin_A	0,10	aurora_A_kinase	48,63	Tripolin A	aurora A kinase	null	6790	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Tripolin_A , a novel small-molecule inhibitor of aurora_A_kinase , reveals new regulation of HURP 's distribution on microtubules .
11367666	0	Tripterine	11,21	c-myc	44,49	Tripterine	c-myc	MESH:C050414	24577(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of Tripterine on mRNA expression of c-myc and platelet derived growth factor of vascular smooth muscle cell in rats -RSB- .
11789240	0	Tripterygium_polyglycoside	11,37	interleukin-6	41,54	Tripterygium polyglycoside	interleukin-6	null	3569	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of Tripterygium_polyglycoside on interleukin-6 in patients with Guillain-Barre_syndrome -RSB- .
12585188	0	Tripterygium_wilfordii_polyglycoside	11,47	IL-2	57,61	Tripterygium wilfordii polyglycoside	IL-2	null	3558	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of Tripterygium_wilfordii_polyglycoside on serum IL-2 and TNF-alpha in patients with acute anterior U-veitis -RSB- .
20194724	0	Triptolide	0,10	APCs	46,50	Triptolide	APCs	MESH:C001899	325	Chemical	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	Triptolide inhibits IL-12 / IL-23 expression in APCs via CCAAT/enhancer-binding _ protein_alpha .
16129490	0	Triptolide	0,10	B7-H1	20,25	Triptolide	B7-H1	MESH:C001899	29126	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Triptolide inhibits B7-H1 expression on proinflammatory factor activated renal tubular epithelial cells by decreasing NF-kappaB transcription .
19240172	0	Triptolide	0,10	Bcr-Abl	20,27	Triptolide	Bcr-Abl	MESH:C001899	25	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|transcription transcription|amod|END_ENTITY	Triptolide inhibits Bcr-Abl transcription and induces apoptosis in STI571-resistant chronic_myelogenous_leukemia cells harboring T315I mutation .
15663903	0	Triptolide	0,10	CD80	22,26	Triptolide	CD80	MESH:C001899	941	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	Triptolide suppresses CD80 and CD86 expressions and IL-12 production in THP-1 cells .
15067740	0	Triptolide	11,21	COX-2	84,89	Triptolide	COX-2	MESH:C001899	5743	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of Triptolide on TNFalpha-induced activation of NF-kappaB and expression of COX-2 and iNOS in human rheumatoid_arthritis synovial fibroblasts -RSB- .
16600409	0	Triptolide	0,10	COX-2	20,25	Triptolide	COX-2	MESH:C001899	29527(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Triptolide inhibits COX-2 expression via NF-kappa_B pathway in astrocytes .
18761708	0	Triptolide	0,10	COX-2	20,25	Triptolide	COX-2	MESH:C001899	5743	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Triptolide inhibits COX-2 expression and PGE2 release by suppressing the activity of NF-kappaB and JNK in LPS-treated microglia .
21717513	0	Triptolide	0,10	COX-2	26,31	Triptolide	COX-2	MESH:C001899	26198(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|expression expression|compound|END_ENTITY	Triptolide down-regulates COX-2 expression and PGE2 release by suppressing the activity of NF-kB and MAP kinases in lipopolysaccharide-treated PC12 cells .
22093832	0	Triptolide	0,10	COX-2	20,25	Triptolide	COX-2	MESH:C001899	5743	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Triptolide inhibits COX-2 expression by regulating mRNA stability in TNF-a-treated A549 cells .
23924856	0	Triptolide	0,10	COX-2	121,126	Triptolide	COX-2	MESH:C001899	5743	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|downregulating downregulating|dobj|END_ENTITY	Triptolide induces apoptosis and inhibits the growth and angiogenesis of human pancreatic_cancer cells by downregulating COX-2 and VEGF .
24289559	0	Triptolide	0,10	EZH2	46,50	Triptolide	EZH2	MESH:C001899	2146	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Triptolide inhibits histone methyltransferase EZH2 and modulates the expression of its target genes in prostate_cancer cells .
26949603	7	Triptolide	961,971	HCFs	1040,1044	Triptolide	IL-6	MESH:C001899	3569	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|nmod|END_ENTITY	RESULTS : Triptolide inhibited the zymosan-induced release of IL-6 , IL-8 , and MCP-1 from HCFs in a concentration - and time-dependent manner .
21433155	0	Triptolide	0,10	IFN-y	20,25	Triptolide	IFN-y	MESH:C001899	3458	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|signaling signaling|compound|END_ENTITY	Triptolide inhibits IFN-y signaling via the Jak/STAT pathway in HaCaT keratinocytes .
19942343	0	Triptolide	0,10	Jak2	20,24	Triptolide	Jak2	MESH:C001899	3717	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|transcription transcription|amod|END_ENTITY	Triptolide inhibits Jak2 transcription and induces apoptosis in human myeloproliferative_disorder cells bearing Jak2V617F through caspase-3-mediated cleavage of Mcl-1 .
25511707	0	Triptolide	0,10	LMP1	128,132	Triptolide	LMP1	MESH:C001899	9260	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|expression expression|nmod|END_ENTITY	Triptolide inhibits proliferation of Epstein-Barr_virus-positive B lymphocytes by down-regulating expression of a viral protein LMP1 .
15067740	0	Triptolide	11,21	NF-kappaB	56,65	Triptolide	NF-kappaB	MESH:C001899	4790	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of Triptolide on TNFalpha-induced activation of NF-kappaB and expression of COX-2 and iNOS in human rheumatoid_arthritis synovial fibroblasts -RSB- .
17970088	0	Triptolide	0,10	NF-kappaB	72,81	Triptolide	NF-kappaB	MESH:C001899	4790	Chemical	Gene	inhibits_tumor|nsubj|START_ENTITY inhibits_tumor|dobj|expression expression|acl|blocking blocking|dobj|END_ENTITY	Triptolide inhibits_tumor promoter-induced uPAR expression via blocking NF-kappaB signaling in human gastric_AGS cells .
18761708	0	Triptolide	0,10	NF-kappaB	85,94	Triptolide	NF-kappaB	MESH:C001899	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|acl|suppressing suppressing|dobj|activity activity|nmod|END_ENTITY	Triptolide inhibits COX-2 expression and PGE2 release by suppressing the activity of NF-kappaB and JNK in LPS-treated microglia .
11501157	0	Triptolide	0,10	NF-kappa_B	34,44	Triptolide	NF-kappa B	MESH:C001899	4790	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	Triptolide : a potent inhibitor of NF-kappa_B in T-lymphocytes .
16600409	0	Triptolide	0,10	NF-kappa_B	41,51	Triptolide	NF-kappa B	MESH:C001899	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|pathway pathway|amod|END_ENTITY	Triptolide inhibits COX-2 expression via NF-kappa_B pathway in astrocytes .
24810483	0	Triptolide	76,86	RANTES	35,41	Triptolide	RANTES	MESH:C001899	81780(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nmod|Effects	Evidence for Involvement of Spinal RANTES in the Antinociceptive Effects of Triptolide , a Diterpene_Triepoxide , in a Rat Model of Bone Cancer_Pain .
19561401	0	Triptolide	0,10	Rac1	25,29	Triptolide	Rac1	MESH:C001899	19353(Tax:10090)	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	Triptolide downregulates Rac1 and the JAK/STAT3 pathway and inhibits colitis-related colon_cancer progression .
25267491	0	Triptolide	0,10	TGF-b1	20,26	Triptolide	TGF-b1	MESH:C001899	59086(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Triptolide inhibits TGF-b1 induced proliferation and migration of rat airway smooth muscle cells by suppressing NF-kB but not ERK1/2 .
26012254	0	Triptolide	0,10	TGF-b1	74,80	Triptolide	TGF-b1	MESH:C001899	59086(Tax:10116)	Chemical	Gene	alleviates|amod|START_ENTITY alleviates|nmod|rats rats|nmod|END_ENTITY	Triptolide alleviates isoprenaline-induced cardiac_remodeling in rats via TGF-b1 / Smad3 and p38_MAPK signaling pathway .
12802209	0	Triptolide	0,10	TNF-alpha	20,29	Triptolide	TNF-alpha	MESH:C001899	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Triptolide inhibits TNF-alpha , IL-1_beta and NO production in primary microglial cultures .
19004508	0	Triptolide	0,10	TNF-alpha	45,54	Triptolide	TNF-alpha	MESH:C001899	24835(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Triptolide inhibits amyloid-beta1-42-induced TNF-alpha and IL-1beta production in cultured rat microglia .
12526088	0	Triptolide	0,10	TNF-related_apoptosis-inducing_ligand	43,80	Triptolide	TNF-related apoptosis-inducing ligand	MESH:C001899	8743	Chemical	Gene	cells|amod|START_ENTITY cells|nmod|END_ENTITY	Triptolide sensitizes lung_cancer cells to TNF-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- - induced apoptosis by inhibition of NF-kappaB activation .
12526088	0	Triptolide	0,10	TRAIL	82,87	Triptolide	TRAIL	MESH:C001899	8743	Chemical	Gene	cells|amod|START_ENTITY cells|appos|END_ENTITY	Triptolide sensitizes lung_cancer cells to TNF-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- - induced apoptosis by inhibition of NF-kappaB activation .
17390080	0	Triptolide	0,10	beta-defensin-2	54,69	Triptolide	beta-defensin-2	MESH:C001899	1673	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Triptolide suppresses interleukin-1beta-induced human beta-defensin-2 mRNA expression through inhibition of transcriptional activation of NF-kappaB in A549 cells .
17277882	0	Triptolide	0,10	cyclooxygenase-2	20,36	Triptolide	cyclooxygenase-2	MESH:C001899	5743	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Triptolide inhibits cyclooxygenase-2 and inducible nitric_oxide synthase expression in human colon_cancer and leukemia cells .
24946563	0	Triptolide	1,11	cyclooxygenase-2	63,79	Triptolide	cyclooxygenase-2	MESH:C001899	5743	Chemical	Gene	inhibites|nsubj|START_ENTITY inhibites|dobj|differentiation differentiation|acl|regulating regulating|dobj|axis axis|amod|END_ENTITY	-LSB- Triptolide inhibites Th17 cell differentiation via regulating cyclooxygenase-2 / prostaglandin_E2 axis in synovial fibroblasts from rheumatoid_arthritis -RSB- .
26631963	0	Triptolide	0,10	hTERT	37,42	Triptolide	hTERT	MESH:C001899	7015	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|transcription transcription|nmod|END_ENTITY	Triptolide inhibits transcription of hTERT through down-regulation of transcription factor specificity_protein_1 in primary effusion_lymphoma cells .
24742042	0	Triptolide	0,10	myeloid_cell_leukemia-1	96,119	Triptolide	myeloid cell leukemia-1	MESH:C001899	4170	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|inhibition inhibition|nmod|END_ENTITY	Triptolide induces apoptotic cell death of human cholangiocarcinoma cells through inhibition of myeloid_cell_leukemia-1 .
18572307	0	Triptolide	0,10	programmed_death-1-ligand_1	45,72	Triptolide	programmed death-1-ligand 1	MESH:C001899	29126	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Triptolide inhibits interferon-gamma-induced programmed_death-1-ligand_1 surface expression in breast_cancer cells .
11749832	0	Triptolide	0,10	vascular_endothelial_growth_factor	20,54	Triptolide	vascular endothelial growth factor	MESH:C001899	7422	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Triptolide inhibits vascular_endothelial_growth_factor expression and production in endothelial cells .
11766607	0	Triptolide	1,11	vascular_endothelial_growth_factor	21,55	Triptolide	vascular endothelial growth factor	MESH:C001899	7422	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	-LSB- Triptolide inhibits vascular_endothelial_growth_factor expression and production by endothelial cells -RSB- .
25279294	0	Tristetraprolin	0,15	BDNF	40,44	Tristetraprolin	BDNF	null	12064(Tax:10090)	Chemical	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	Tristetraprolin is a novel regulator of BDNF .
26343742	0	Tristetraprolin	40,55	EGR1	121,125	Tristetraprolin	EGR1	null	1958	Chemical	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	Histone_Deacetylase Inhibitors Activate Tristetraprolin Expression through Induction of Early_Growth_Response_Protein_1 -LRB- EGR1 -RRB- in Colorectal_Cancer_Cells .
26343742	0	Tristetraprolin	40,55	Histone_Deacetylase	0,19	Tristetraprolin	Histone Deacetylase	null	9734	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Histone_Deacetylase Inhibitors Activate Tristetraprolin Expression through Induction of Early_Growth_Response_Protein_1 -LRB- EGR1 -RRB- in Colorectal_Cancer_Cells .
19363120	0	Tristetraprolin	0,15	IL-8	26,30	Tristetraprolin	IL-8	null	3576	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|stability stability|compound|END_ENTITY	Tristetraprolin regulates IL-8 mRNA stability in cystic_fibrosis lung epithelial cells .
21830391	0	Tristetraprolin	0,15	VEGF	53,57	Tristetraprolin	VEGF	null	7422	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|nmod|END_ENTITY	Tristetraprolin downregulates the expression of both VEGF and COX-2 in human colon_cancer .
17937985	0	Trisubstituted_pyrimidines	0,26	transient_receptor_potential_vanilloid_1	30,70	Trisubstituted pyrimidines	transient receptor potential vanilloid 1	null	83810(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|antagonists antagonists|amod|END_ENTITY	Trisubstituted_pyrimidines as transient_receptor_potential_vanilloid_1 -LRB- TRPV1 -RRB- antagonists with improved solubility .
21295979	0	Trisubstituted_ureas	0,20	mPGES-1	45,52	Trisubstituted ureas	mPGES-1	null	64292(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Trisubstituted_ureas as potent and selective mPGES-1 inhibitors .
19911564	0	Triterpenes	0,11	acetylcholinesterase	68,88	Triterpenes	acetylcholinesterase	MESH:D014315	43	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Triterpenes from Warszewiczia coccinea -LRB- Rubiaceae -RRB- as inhibitors of acetylcholinesterase .
17489355	0	Triterpenoids	0,13	HIF-1	62,67	Triterpenoids	HIF-1	CHEBI:36615	3091	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|END_ENTITY	Triterpenoids and diarylheptanoids from Alnus hirsuta inhibit HIF-1 in AGS cells .
22327	0	Tritium	0,7	catalase	51,59	Tritium	catalase	CHEBI:29304	24248(Tax:10116)	Chemical	Gene	effect|amod|START_ENTITY effect|nmod|END_ENTITY	Tritium effect in peroxidation of ehtanol by liver catalase .
26551587	0	Tritium	0,7	milk	18,22	Tritium	milk	CHEBI:29304	100532204	Chemical	Gene	levels|amod|START_ENTITY levels|nmod|END_ENTITY	Tritium levels in milk in the vicinity of chronic tritium releases .
17237309	0	Triton_WR1339	0,13	lipoprotein_lipase	31,49	Triton WR1339	lipoprotein lipase	MESH:C016811	24539(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Triton_WR1339 , an inhibitor of lipoprotein_lipase , decreases vitamin_E concentration in some tissues of rats by inhibiting its transport to liver .
25354527	0	Trivalent_Chromium	0,18	TSP-1	28,33	Trivalent Chromium	TSP-1	null	7057	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Trivalent_Chromium Inhibits TSP-1 Expression , Proliferation and O-GlcNAc signaling in Vascular Smooth Muscle Cells in Response to High Glucose in Vitro .
23006633	0	Trivaric_acid	0,13	leukocyte_elastase	38,56	Trivaric acid	leukocyte elastase	MESH:C581105	1991	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Trivaric_acid , a potent depside human leukocyte_elastase inhibitor .
16446079	0	Troglitazone	0,12	COX-2	26,31	Troglitazone	COX-2	MESH:C057693	19225(Tax:10090)	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|expression expression|compound|END_ENTITY	Troglitazone induction of COX-2 expression is dependent on ERK activation in keratinocytes .
12062933	0	Troglitazone	0,12	CYP3A	70,75	Troglitazone	CYP3A	MESH:C057693	170509(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|advcl|inducing inducing|dobj|END_ENTITY	Troglitazone enhances the hepatotoxicity of acetaminophen by inducing CYP3A in rats .
19285010	0	Troglitazone	0,12	E-cadherin	37,47	Troglitazone	E-cadherin	MESH:C057693	999	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Troglitazone increases expression of E-cadherin and claudin_4 in human pancreatic_cancer cells .
11334413	0	Troglitazone	0,12	GLUT4	21,26	Troglitazone	GLUT4	MESH:C057693	6517	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|translocation translocation|nummod|END_ENTITY	Troglitazone induces GLUT4 translocation in L6 myotubes .
11574411	0	Troglitazone	0,12	GLUT4	32,37	Troglitazone	GLUT4	MESH:C057693	25139(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Troglitazone not only increases GLUT4 but also induces its translocation in rat adipocytes .
11947963	0	Troglitazone	0,12	GLUT4	22,27	Troglitazone	GLUT4	MESH:C057693	25139(Tax:10116)	Chemical	Gene	improves|nsubj|START_ENTITY improves|dobj|expression expression|nummod|END_ENTITY	Troglitazone improves GLUT4 expression in adipose tissue in an animal model of obese_type_2_diabetes_mellitus .
12659874	0	Troglitazone	0,12	IGF-binding_protein-1	24,45	Troglitazone	IGF-binding protein-1	MESH:C057693	3484	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Troglitazone stimulates IGF-binding_protein-1 by a PPAR_gamma-independent mechanism .
11891015	0	Troglitazone	0,12	INS-1	60,65	Troglitazone	INS-1	MESH:C057693	24505(Tax:10116)	Chemical	Gene	ameliorates|nsubj|START_ENTITY ameliorates|nmod|END_ENTITY	Troglitazone ameliorates lipotoxicity in the beta cell line INS-1 expressing PPAR_gamma .
9516220	1	Troglitazone	83,95	Insulin	110,117	Troglitazone	Insulin	MESH:C057693	3630	Chemical	Gene	START_ENTITY|dep|Group Group|compound|END_ENTITY	Troglitazone and Exogenous Insulin Study Group .
9727891	1	Troglitazone	66,78	Insulin	79,86	Troglitazone	Insulin	MESH:C057693	3630	Chemical	Gene	Group|compound|START_ENTITY Group|compound|END_ENTITY	The Troglitazone Insulin Study Group .
21461570	0	Troglitazone	0,12	NAG-1	67,72	Troglitazone	NAG-1	MESH:C057693	9518	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|pathway pathway|compound|END_ENTITY	Troglitazone induces apoptosis in gastric_cancer cells through the NAG-1 pathway .
21613824	0	Troglitazone	0,12	PPAR	16,20	Troglitazone	PPAR	MESH:C057693	5465	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Troglitazone , a PPAR agonist , inhibits human prostate_cancer cell growth through inactivation of NFkB via suppression of GSK-3b expression .
15694007	0	Troglitazone	0,12	PPAR-gamma	16,26	Troglitazone	PPAR-gamma	MESH:C057693	5468	Chemical	Gene	prevents|advmod|START_ENTITY prevents|nsubj|activator activator|amod|END_ENTITY	Troglitazone , a PPAR-gamma activator prevents endothelial cell adhesion molecule expression and lymphocyte adhesion mediated by TNF-alpha .
12475986	0	Troglitazone	0,12	PPAR_gamma	66,76	Troglitazone	PPAR gamma	MESH:C057693	5468	Chemical	Gene	START_ENTITY|appos|peroxisome_proliferator-activated_receptor_gamma peroxisome_proliferator-activated_receptor_gamma|appos|END_ENTITY	Troglitazone , a peroxisome_proliferator-activated_receptor_gamma -LRB- PPAR_gamma -RRB- ligand , selectively induces the early_growth_response-1 gene independently of PPAR_gamma .
10662598	0	Troglitazone	0,12	PPARgamma	35,44	Troglitazone	PPARgamma	MESH:C057693	25664(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Troglitazone induces expression of PPARgamma in liver .
11426586	0	Troglitazone	0,12	PPARgamma	16,25	Troglitazone	PPARgamma	MESH:C057693	5468	Chemical	Gene	START_ENTITY|appos|ligand ligand|compound|END_ENTITY	Troglitazone , a PPARgamma ligand , inhibits osteopontin gene expression in human monocytes/macrophage THP-1 cells .
11443177	0	Troglitazone	0,12	PPARgamma	39,48	Troglitazone	PPARgamma	MESH:C057693	5468	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|nmod|END_ENTITY	Troglitazone reduces the expression of PPARgamma while stimulating that of PPARalpha in mononuclear cells in obese subjects .
11834241	0	Troglitazone	0,12	PPARgamma	68,77	Troglitazone	PPARgamma	MESH:C057693	5468	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|growth growth|nmod|cells cells|nmod|END_ENTITY	Troglitazone suppresses cell growth of KU812 cells independently of PPARgamma .
14506076	0	Troglitazone	0,12	PPARgamma	21,30	Troglitazone	PPARgamma	MESH:C057693	397671(Tax:9823)	Chemical	Gene	acts|amod|START_ENTITY acts|nmod|END_ENTITY	Troglitazone acts by PPARgamma and PPARgamma-independent pathways on LLC-PK1-F + acid-base metabolism .
15610522	0	Troglitazone	0,12	PPARgamma	77,86	Troglitazone	PPARgamma	MESH:C057693	19016(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Troglitazone inhibits cyclin_D1 expression and cell cycling independently of PPARgamma in normal mouse skin keratinocytes .
20650001	0	Troglitazone	0,12	PPARgamma	61,70	Troglitazone	PPARgamma	MESH:C057693	5468	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|activity activity|nmod|END_ENTITY	Troglitazone suppresses telomerase activity independently of PPARgamma in estrogen-receptor negative breast_cancer cells .
25413077	0	Troglitazone	1,13	PPARy	71,76	Troglitazone	PPARy	MESH:C057693	5468	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	-LSB- Troglitazone suppresses ICAM-1 and MMP-9 expressions by up-regulating PPARy in HeLa cells -RSB- .
24026200	0	Troglitazone	0,12	PTEN	25,29	Troglitazone	PTEN	MESH:C057693	5728	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	Troglitazone upregulates PTEN expression and induces the apoptosis of pulmonary artery smooth muscle cells under hypoxic conditions .
12717389	0	Troglitazone	0,12	Skp2	82,86	Troglitazone	Skp2	MESH:C057693	6502	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Troglitazone induces p27Kip1-associated cell-cycle arrest through down-regulating Skp2 in human hepatoma cells .
15610522	0	Troglitazone	0,12	cyclin_D1	22,31	Troglitazone	cyclin D1	MESH:C057693	12443(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Troglitazone inhibits cyclin_D1 expression and cell cycling independently of PPARgamma in normal mouse skin keratinocytes .
11916926	0	Troglitazone	0,12	delta-6_desaturase	27,45	Troglitazone	delta-6 desaturase	MESH:C057693	9415	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	Troglitazone downregulates delta-6_desaturase gene expression in human skeletal muscle cell cultures .
21109961	0	Troglitazone	0,12	epidermal_growth_factor_receptor	24,56	Troglitazone	epidermal growth factor receptor	MESH:C057693	1956	Chemical	Gene	attenuates|amod|START_ENTITY END_ENTITY|nsubj|attenuates	Troglitazone attenuates epidermal_growth_factor_receptor signaling independently of peroxisome proliferator-activated receptor in PC-3 cells .
11719831	0	Troglitazone	0,12	glyoxalase_I	34,46	Troglitazone	glyoxalase I	MESH:C057693	2739	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Troglitazone selectively inhibits glyoxalase_I gene expression .
20454582	0	Troglitazone	0,12	glyoxalase_I	21,33	Troglitazone	glyoxalase I	MESH:C057693	2739	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|amod|END_ENTITY	Troglitazone reduces glyoxalase_I protein expression in glioma and potentiates the effects of chemotherapeutic agents .
10807673	0	Troglitazone	0,12	insulin	57,64	Troglitazone	insulin	MESH:C057693	3630	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|dobj|resistance resistance|compound|END_ENTITY	Troglitazone prevents and reverses dexamethasone induced insulin resistance on glycogen synthesis in 3T3 adipocytes .
11480457	0	Troglitazone	0,12	insulin	63,70	Troglitazone	insulin	MESH:C057693	3630	Chemical	Gene	improves|nsubj|START_ENTITY improves|nmod|patients patients|nmod|resistance resistance|compound|END_ENTITY	Troglitazone improves endothelial_dysfunction in patients with insulin resistance .
9215280	0	Troglitazone	0,12	insulin	33,40	Troglitazone	insulin	MESH:C057693	3630	Chemical	Gene	improves|nsubj|START_ENTITY improves|dobj|defects defects|nmod|action action|compound|END_ENTITY	Troglitazone improves defects in insulin action , insulin secretion , ovarian steroidogenesis , and fibrinolysis in women with polycystic_ovary_syndrome .
9752901	0	Troglitazone	0,12	insulin	17,24	Troglitazone	insulin	MESH:C057693	3630	Chemical	Gene	START_ENTITY|appos|sensitizer sensitizer|compound|END_ENTITY	Troglitazone , an insulin sensitizer , increases forearm blood flow in humans .
9925352	0	Troglitazone	0,12	insulin	25,32	Troglitazone	insulin	MESH:C057693	3630	Chemical	Gene	ameliorates|nsubj|START_ENTITY ameliorates|dobj|resistance resistance|compound|END_ENTITY	Troglitazone ameliorates insulin resistance in a diabetic patient with Prader-Willi_syndrome .
9727893	0	Troglitazone	0,12	leptin	28,34	Troglitazone	leptin	MESH:C057693	3952	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|concentration concentration|compound|END_ENTITY	Troglitazone reduces plasma leptin concentration but increases hunger in NIDDM patients .
11426586	0	Troglitazone	0,12	osteopontin	43,54	Troglitazone	osteopontin	MESH:C057693	6696	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Troglitazone , a PPARgamma ligand , inhibits osteopontin gene expression in human monocytes/macrophage THP-1 cells .
10334298	0	Troglitazone	0,12	peroxisome_proliferator-activated_receptor-gamma	106,154	Troglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C057693	19016(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|independent independent|nmod|END_ENTITY	Troglitazone , an antidiabetic agent , inhibits cholesterol biosynthesis through a mechanism independent of peroxisome_proliferator-activated_receptor-gamma .
10815854	0	Troglitazone	0,12	peroxisome_proliferator-activated_receptor-gamma	97,145	Troglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C057693	5468	Chemical	Gene	improves|nsubj|START_ENTITY improves|parataxis|inhibit inhibit|nsubj|ligands ligands|nmod|END_ENTITY	Troglitazone improves psoriasis and normalizes models of proliferative_skin_disease : ligands for peroxisome_proliferator-activated_receptor-gamma inhibit keratinocyte proliferation .
15785241	0	Troglitazone	0,12	peroxisome_proliferator-activated_receptor-gamma	18,66	Troglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C057693	5468	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Troglitazone , the peroxisome_proliferator-activated_receptor-gamma agonist , induces antiproliferation and redifferentiation in human thyroid_cancer cell lines .
16787414	0	Troglitazone	0,12	peroxisome_proliferator-activated_receptor-gamma	16,64	Troglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C057693	5468	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Troglitazone , a peroxisome_proliferator-activated_receptor-gamma agonist , decreases tau phosphorylation in CHOtau4R cells .
9709955	0	Troglitazone	0,12	peroxisome_proliferator-activated_receptor-gamma	110,158	Troglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C057693	5468	Chemical	Gene	effects|amod|START_ENTITY involve|nsubj|effects involve|dobj|up-regulation up-regulation|nmod|END_ENTITY	Troglitazone effects on gene expression in human skeletal muscle of type_II_diabetes involve up-regulation of peroxisome_proliferator-activated_receptor-gamma .
11346461	0	Troglitazone	0,12	peroxisome_proliferator-activated_receptor_gamma	27,75	Troglitazone	peroxisome proliferator-activated receptor gamma	MESH:C057693	25664(Tax:10116)	Chemical	Gene	START_ENTITY|appos|ligand ligand|nmod|END_ENTITY	Troglitazone , a ligand for peroxisome_proliferator-activated_receptor_gamma , inhibits chemically-induced aberrant_crypt_foci in rats .
18407589	0	Troglitazone	0,12	peroxisome_proliferator-activated_receptor_gamma	16,64	Troglitazone	peroxisome proliferator-activated receptor gamma	MESH:C057693	5468	Chemical	Gene	START_ENTITY|appos|ligand ligand|amod|END_ENTITY	Troglitazone , a peroxisome_proliferator-activated_receptor_gamma ligand , induces growth inhibition and apoptosis of HepG2 human liver_cancer cells .
10768100	0	Troglitazone	0,12	plasminogen_activator_inhibitor-1	21,54	Troglitazone	plasminogen activator inhibitor-1	MESH:C057693	5054	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|amod|END_ENTITY	Troglitazone reduces plasminogen_activator_inhibitor-1 expression and secretion in cultured human adipocytes .
15051625	0	Trolox	11,17	cytochrome_P450	57,72	Trolox	cytochrome P450	MESH:C010643	25251(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of Trolox on the activity and gene expression of cytochrome_P450 in hepatic_ischemia / reperfusion .
21485729	0	Troponin_I	0,10	C-reactive_protein	12,30	Troponin I	C-reactive protein	null	1401	Chemical	Gene	START_ENTITY|appos|levels levels|compound|END_ENTITY	Troponin_I , C-reactive_protein and fibrinogen levels in missed_abortions .
21533915	0	Troponin_I	60,70	TNNI3	72,77	Troponin I	TNNI3	null	7137	Chemical	Gene	mutations|amod|START_ENTITY mutations|appos|END_ENTITY	Recurrent and founder mutations in the Netherlands : cardiac Troponin_I -LRB- TNNI3 -RRB- gene mutations as a cause of severe forms of hypertrophic and restrictive_cardiomyopathy .
12809519	0	Troponin_I	0,10	polycystin-L	17,29	Troponin I	polycystin-L	null	329064(Tax:10090)	Chemical	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Troponin_I binds polycystin-L and inhibits its calcium-induced channel activation .
11943213	0	Troponin_I	0,10	skeletal_muscle_ryanodine_receptor	24,58	Troponin I	skeletal muscle ryanodine receptor	null	6261	Chemical	Gene	converts|nsubj|START_ENTITY converts|dobj|END_ENTITY	Troponin_I converts the skeletal_muscle_ryanodine_receptor into a rectifying calcium release channel .
24992688	2	Troponin_T	382,392	cTnT	394,398	Troponin T	cTnT	null	7139	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Our aim in the present study is to investigate the genetic variations in Troponin_T -LRB- cTnT -RRB- gene and its association with dilated_cardiomyopathy -LRB- DCM -RRB- in south-Indian patients .
10671485	0	Trypsin	0,7	proteinase-activated_receptor-2	151,182	Trypsin	proteinase-activated receptor-2	null	2150	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|activation activation|nmod|END_ENTITY	Trypsin stimulates integrin alpha -LRB- 5 -RRB- beta -LRB- 1 -RRB- - dependent adhesion to fibronectin and proliferation of human gastric_carcinoma cells through activation of proteinase-activated_receptor-2 .
9170145	0	Tryptamine	0,10	CYP2D6	48,54	Tryptamine	CYP2D6	MESH:C030820	1565	Chemical	Gene	START_ENTITY|dep|substrate substrate|nmod|END_ENTITY	Tryptamine : a possible endogenous substrate for CYP2D6 .
9428687	0	Tryptamine	0,10	copper_amine_oxidase	57,77	Tryptamine	copper amine oxidase	MESH:C030820	8639	Chemical	Gene	START_ENTITY|nmod|substrate substrate|nmod|END_ENTITY	Tryptamine as substrate and inhibitor of lentil seedling copper_amine_oxidase .
3871227	0	Tryptamine	0,10	serotonin_transporter	32,53	Tryptamine	serotonin transporter	MESH:C030820	6532	Chemical	Gene	START_ENTITY|appos|substrate substrate|nmod|END_ENTITY	Tryptamine , a substrate for the serotonin_transporter in human platelets , modifies the dissociation kinetics of -LSB- 3H -RSB- imipramine binding : possible allosteric interaction .
24358167	0	Tryptanthrin	0,12	ERK1/2	68,74	Tryptanthrin	ERK1/2	MESH:C046243	5595;5594	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	Tryptanthrin inhibits angiogenesis by targeting the VEGFR2-mediated ERK1/2 signalling pathway .
17482571	0	Tryptanthrin	0,12	MDR1	22,26	Tryptanthrin	MDR1	MESH:C046243	5243	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Tryptanthrin inhibits MDR1 and reverses doxorubicin resistance in breast_cancer cells .
12612449	0	Tryptanthrin	0,12	interferon-gamma	22,38	Tryptanthrin	interferon-gamma	MESH:C046243	15978(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Tryptanthrin inhibits interferon-gamma production by Peyer 's patch lymphocytes derived from mice that had been orally administered staphylococcal enterotoxin .
11257521	0	Tryptophan	0,10	adenosine_deaminase	26,45	Tryptophan	adenosine deaminase	CHEBI:27897	280712(Tax:9913)	Chemical	Gene	environment|compound|START_ENTITY environment|nmod|END_ENTITY	Tryptophan environment in adenosine_deaminase .
17239857	0	Tryptophan	0,10	cytochrome_c_oxidase_subunit_I	35,65	Tryptophan	cytochrome c oxidase subunit I	CHEBI:27897	3283879(Tax:9913)	Chemical	Gene	oxidation|compound|START_ENTITY oxidation|nmod|END_ENTITY	Tryptophan 334 oxidation in bovine cytochrome_c_oxidase_subunit_I involves free radical migration .
16707241	0	Tryptophan	0,10	ghrelin	20,27	Tryptophan	ghrelin	CHEBI:27897	396728(Tax:9823)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	Tryptophan enhances ghrelin expression and secretion associated with increased food intake and weight_gain in weanling pigs .
1862519	0	Tryptophan	0,10	phospholipase_A2	23,39	Tryptophan	phospholipase A2	CHEBI:27897	151056	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	Tryptophan residues of phospholipase_A2 from the venom of an Australian elapid snake -LRB- Pseudechis australis -RRB- .
12829505	0	Tryptophan	0,10	plasminogen_activator_inhibitor_1	66,99	Tryptophan	plasminogen activator inhibitor 1	CHEBI:27897	5054	Chemical	Gene	properties|compound|START_ENTITY properties|nmod|END_ENTITY	Tryptophan properties in fluorescence and functional stability of plasminogen_activator_inhibitor_1 .
25169767	0	Tryptophan	0,10	serine_protease	79,94	Tryptophan	serine protease	CHEBI:27897	2147	Chemical	Gene	environment|amod|START_ENTITY environment|nmod|END_ENTITY	Tryptophan environment and functional characterization of a kinetically stable serine_protease containing a polyproline II fold .
26927553	0	Tubacin	1,8	CD4	69,72	Tubacin	CD4	MESH:C474316	12504(Tax:10090)	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|nmod|END_ENTITY	-LSB- Tubacin promotes Foxp3 expression and suppressive function of mouse CD4 -LRB- + -RRB- ; CD25 -LRB- + -RRB- ; regulatory T cells -RSB- .
23538448	0	Tubastatin_A	149,161	HDAC6	21,26	Tubastatin A	HDAC6	MESH:C553587	10013	Chemical	Gene	analogues|nmod|START_ENTITY activity|dep|analogues activity|compound|END_ENTITY	Potent and selective HDAC6 inhibitory activity of N - -LRB- 4-hydroxycarbamoylbenzyl -RRB- -1,2,4,9 - tetrahydro-3-thia-9-azafluorenes as novel sulfur analogues of Tubastatin_A .
24909686	0	Tubastatin_A	79,91	HDAC6	63,68	Tubastatin A	HDAC6	MESH:C553587	10013	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|Involvement Involvement|nmod|XBP1s XBP1s|nmod|resistance resistance|nmod|END_ENTITY	Involvement of transcription factor XBP1s in the resistance of HDAC6 inhibitor Tubastatin_A to superoxidation via acetylation-mediated proteasomal degradation .
26790818	0	Tubastatin_A	0,12	HDAC6	17,22	Tubastatin A	HDAC6	MESH:C553587	84581(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Tubastatin_A , an HDAC6 inhibitor , alleviates stroke-induced brain_infarction and functional deficits : potential roles of a-tubulin acetylation and FGF-21 up-regulation .
16702951	0	Tuberin	0,7	BAD	44,47	Tuberin	BAD	null	572	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Tuberin activates the proapoptotic molecule BAD .
17989114	0	Tuberin	0,7	OGG1	40,44	Tuberin	OGG1	null	4968	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Tuberin regulates the DNA repair enzyme OGG1 .
15355997	0	Tuberin	0,7	p27	14,17	Tuberin	p27	null	10671	Chemical	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Tuberin binds p27 and negatively regulates its interaction with the SCF component Skp2 .
2786082	0	Tuftsin	0,7	IL-1	19,23	Tuftsin	IL-1	MESH:D014405	3552	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|compound|END_ENTITY	Tuftsin stimulates IL-1 production by human mononuclear cells , human spleen cells and mouse spleen cells in vitro .
22821808	0	Tunicamycin	0,11	HO-1	118,122	Tunicamycin	HO-1	MESH:D014415	3162	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|induction induction|nmod|END_ENTITY	Tunicamycin inhibits PDGF-BB-induced proliferation and migration of vascular smooth muscle cells through induction of HO-1 .
11171045	0	Tunicamycin	0,11	apolipoprotein_B	54,70	Tunicamycin	apolipoprotein B	MESH:D014415	338	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|ubiquitination ubiquitination|nmod|END_ENTITY	Tunicamycin induces ubiquitination and degradation of apolipoprotein_B in HepG2 cells .
6457668	0	Tunicamycin	1,12	thyroglobulin	59,72	Tunicamycin	thyroglobulin	MESH:D014415	24826(Tax:10116)	Chemical	Gene	inhibition|nsubj|START_ENTITY inhibition|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Tunicamycin inhibition of carbohydrate incorporation into thyroglobulin -RSB- .
8267715	0	Ty3	72,75	POL3	43,47	Ty3	POL3	null	851456(Tax:4932)	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	A novel programed frameshift expresses the POL3 gene of retrotransposon Ty3 of yeast : frameshifting without tRNA slippage .
8810619	0	Tyloxapol	0,9	NF-kappa_B	19,29	Tyloxapol	NF-kappa B	MESH:C016811	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|amod|END_ENTITY	Tyloxapol inhibits NF-kappa_B and cytokine release , scavenges HOCI , and reduces viscosity of cystic_fibrosis_sputum .
7700853	0	Tyr-W-MIF-1	82,93	FOS	18,21	Tyr-W-MIF-1	FOS	MESH:C077532	314322(Tax:10116)	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|protein protein|compound|END_ENTITY	Expression of the FOS proto-oncogene protein in brain after ICV administration of Tyr-W-MIF-1 -LRB- Tyr-Pro-Trp-Gly-NH2 -RRB- .
24406398	0	Tyrosine	0,8	3BP2	28,32	Tyrosine	3BP2	CHEBI:18186	24055(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of 3BP2 is indispensable for the interaction with VAV3 in chicken DT40 cells .
25770215	0	Tyrosine	9,17	A-kinase_Anchoring_Protein_8	37,65	Tyrosine	A-kinase Anchoring Protein 8	D014443	10270	Chemical	Gene	Phosphorylation|compound|START_ENTITY Phosphorylation|nmod|END_ENTITY	Role for Tyrosine Phosphorylation of A-kinase_Anchoring_Protein_8 -LRB- AKAP8 -RRB- in Its Dissociation from Chromatin and the Nuclear Matrix .
10438817	0	Tyrosine	0,8	A17	28,31	Tyrosine	A17	CHEBI:18186	28919	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of A17 during vaccinia_virus_infection : involvement of the H1 phosphatase and the F10 kinase .
25803821	0	Tyrosine	4,12	ABL	0,3	Tyrosine	ABL	CHEBI:18186	25	Chemical	Gene	Effects|compound|START_ENTITY Effects|compound|END_ENTITY	ABL Tyrosine Kinase Inhibition Variable Effects on the Invasive Properties of Different Triple Negative Breast_Cancer Cell Lines .
8647288	0	Tyrosine	0,8	ACK	28,31	Tyrosine	ACK	CHEBI:18186	10188	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of ACK in response to temperature shift-down , hyperosmotic_shock , and epidermal growth factor stimulation .
25148682	0	Tyrosine	5,13	ACK1	0,4	Tyrosine	ACK1	CHEBI:18186	10188	Chemical	Gene	Kinase|compound|START_ENTITY Kinase|compound|END_ENTITY	ACK1 Tyrosine Kinase Interacts with Histone Demethylase KDM3A to Regulate the Mammary_Tumor_Oncogene_HOXA1 .
25601159	0	Tyrosine	0,8	ATM	32,35	Tyrosine	ATM	CHEBI:18186	472	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine 370 phosphorylation of ATM positively regulates DNA damage response .
24744988	0	Tyrosine	123,131	AXL	183,186	Tyrosine	AXL	CHEBI:18186	558	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|nmod|Globally Globally|amod|RTK-Rearranged RTK-Rearranged|dep|ROS1 ROS1|dep|RET RET|parataxis|END_ENTITY	Will the Requirement by the US FDA to Simultaneously Co-Develop Companion Diagnostics -LRB- CDx -RRB- Delay the Approval of Receptor Tyrosine Kinase Inhibitors for RTK-Rearranged -LRB- ROS1 - , RET - , AXL - , PDGFR-a - , NTRK1 - -RRB- Non-Small_Cell_Lung_Cancer Globally ?
16291652	8	Tyrosine	1087,1095	Abl	1182,1185	Tyrosine	Btk	CHEBI:18186	374075(Tax:9031)	Chemical	Gene	phosphorylation|amod|START_ENTITY shown|nsubjpass|phosphorylation shown|xcomp|regulate regulate|dobj|function function|nmod|END_ENTITY	Tyrosine phosphorylation in the linker region was previously shown to regulate the function of Abl and ZAP70/Syk kinases .
26213100	0	Tyrosine	41,49	Acp1	63,67	Tyrosine	Acp1	D014443	11431(Tax:10090)	Chemical	Gene	Phosphatase|compound|START_ENTITY Phosphatase|appos|END_ENTITY	Deletion of Low Molecular Weight Protein Tyrosine Phosphatase -LRB- Acp1 -RRB- Protects Against Stress-Induced Cardiomyopathy .
26235616	0	Tyrosine	15,23	Aha1	43,47	Tyrosine	Aha1	D014443	10598	Chemical	Gene	Phosphorylation|compound|START_ENTITY Phosphorylation|nmod|END_ENTITY	c-Abl Mediated Tyrosine Phosphorylation of Aha1 Activates Its Co-chaperone Function in Cancer Cells .
10919641	0	Tyrosine	0,8	Akt	50,53	Tyrosine	Akt	CHEBI:18186	24185(Tax:10116)	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|nmod|END_ENTITY	Tyrosine 1062 of RET-MEN2A mediates activation of Akt -LRB- protein kinase B -RRB- and mitogen-activated protein kinase pathways leading to PC12 cell survival .
8353288	0	Tyrosine	0,8	BCR-ABL	45,52	Tyrosine	BCR-ABL	CHEBI:18186	25	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of P160 BCR by P210 BCR-ABL .
10551883	0	Tyrosine	0,8	BNIP-2	57,63	Tyrosine	BNIP-2	CHEBI:18186	663	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of the Bcl-2-associated protein BNIP-2 by fibroblast_growth_factor_receptor-1 prevents its binding to Cdc42GAP and Cdc42 .
23825946	0	Tyrosine	9,17	BTK	26,29	Tyrosine	BTK	CHEBI:18186	12229(Tax:10090)	Chemical	Gene	Kinase|compound|START_ENTITY Kinase|appos|END_ENTITY	Bruton 's Tyrosine Kinase -LRB- BTK -RRB- and Vav1 contribute to Dectin1-dependent phagocytosis of Candida_albicans in macrophages .
7514299	0	Tyrosine	0,8	Blk	28,31	Tyrosine	Blk	CHEBI:18186	640	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|proteins proteins|compound|END_ENTITY	Tyrosine phosphorylation of Blk and Fyn Src homology 2 domain-binding proteins occurs in response to antigen-receptor ligation in B cells and constitutively in pre-B cells .
7518558	0	Tyrosine	0,8	Bruton_tyrosine_kinase	43,65	Tyrosine	Bruton tyrosine kinase	CHEBI:18186	12229(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation and activation of Bruton_tyrosine_kinase upon Fc_epsilon_RI cross-linking .
25993510	0	Tyrosine	31,39	C-Maf	25,30	Tyrosine	C-Maf	D014443	4094	Chemical	Gene	Phosphorylation|compound|START_ENTITY Phosphorylation|compound|END_ENTITY	Reciprocal Regulation of C-Maf Tyrosine Phosphorylation by Tec and Ptpn22 .
23997214	0	Tyrosine	0,8	CD13	28,32	Tyrosine	CD13	CHEBI:18186	290	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of CD13 regulates inflammatory cell-cell adhesion and monocyte trafficking .
22898603	0	Tyrosine	0,8	CD148	34,39	Tyrosine	CD148	CHEBI:18186	19271(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of DEP-1 / CD148 as a mechanism controlling Src kinase activation , endothelial cell permeability , invasion , and capillary formation .
7687539	0	Tyrosine	0,8	CD19	28,32	Tyrosine	CD19	CHEBI:18186	930	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of CD19 in pre-B and mature B cells .
9736336	0	Tyrosine	44,52	CD20	24,28	Tyrosine	CD20	CHEBI:18186	54474	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	The association between CD20 and Src-family Tyrosine kinases requires an additional factor .
1279802	0	Tyrosine	0,8	CD22	28,32	Tyrosine	CD22	CHEBI:18186	933	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of CD22 during B cell activation .
8576149	0	Tyrosine	0,8	CD38	94,98	Tyrosine	CD38	CHEBI:18186	952	Chemical	Gene	phosphorylation|amod|START_ENTITY mediated|nsubj|phosphorylation mediated|nmod|END_ENTITY	Tyrosine phosphorylation of the c-cbl proto-oncogene product mediated by cell surface antigen CD38 in HL-60 cells .
7507203	0	Tyrosine	0,8	CD45	28,32	Tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|phosphatase phosphatase|nummod|END_ENTITY	Tyrosine phosphorylation of CD45 phosphotyrosine phosphatase by p50csk kinase creates a binding site for p56lck tyrosine kinase and activates the phosphatase .
7678115	0	Tyrosine	0,8	CD6	28,31	Tyrosine	CD6	CHEBI:18186	923	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of CD6 by stimulation of CD3 : augmentation by the CD4 and CD2 coreceptors .
9742969	0	Tyrosine	0,8	CDC42	96,101	Tyrosine	CDC42	CHEBI:18186	64465(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY regulated|nsubjpass|phosphorylation regulated|nmod|END_ENTITY	Tyrosine phosphorylation of the Wiskott-Aldrich_syndrome protein by Lyn and Btk is regulated by CDC42 .
25320964	0	Tyrosine	103,111	CK1	71,74	Tyrosine	CK1	CHEBI:18186	122011	Chemical	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|compound|END_ENTITY	Efficient Modification of Alpha-Synuclein Serine 129 by Protein Kinase CK1 Requires Phosphorylation of Tyrosine 125 as a Priming Event .
7521685	0	Tyrosine	0,8	CRKL	28,32	Tyrosine	CRKL	CHEBI:18186	1399	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of CRKL in Philadelphia + leukemia .
8662998	0	Tyrosine	0,8	Cbl	28,31	Tyrosine	Cbl	CHEBI:18186	867	Chemical	Gene	START_ENTITY|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of Cbl upon epidermal_growth_factor -LRB- EGF -RRB- stimulation and its association with EGF receptor and downstream signaling proteins .
7478571	0	Tyrosine	0,8	Crkl	35,39	Tyrosine	Crkl	CHEBI:18186	12929(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of murine Crkl .
10896106	0	Tyrosine	0,8	Csk	73,76	Tyrosine	Csk	CHEBI:18186	1445	Chemical	Gene	analogues|amod|START_ENTITY analogues|nmod|substrates substrates|nmod|END_ENTITY	Tyrosine analogues as alternative substrates for protein tyrosine kinase Csk : insights into substrate selectivity and catalytic mechanism .
24778185	0	Tyrosine	0,8	Dbl	28,31	Tyrosine	Dbl	CHEBI:18186	4168	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of Dbl regulates GTPase signaling .
14559149	0	Tyrosine	0,8	Disabled-1	28,38	Tyrosine	Disabled-1	CHEBI:18186	13131(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of Disabled-1 is essential for Reelin-stimulated activation of Akt and Src family kinases .
2537075	0	Tyrosine	0,8	EGF	40,43	Tyrosine	EGF	CHEBI:18186	1950	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|receptor receptor|compound|END_ENTITY	Tyrosine protein kinase activity of the EGF receptor is required to induce activation of receptor-operated calcium channels .
23066441	0	Tyrosine	5,13	EGFR	0,4	Tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	Proliferation|compound|START_ENTITY Proliferation|compound|END_ENTITY	EGFR Tyrosine 845 Phosphorylation-Dependent Proliferation and Transformation of Breast_Cancer Cells Require Activation of p38 MAPK .
23483646	0	Tyrosine	231,239	EGFR	226,230	Tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	Treatment|compound|START_ENTITY Treatment|compound|END_ENTITY	Comparison of Direct Sequencing , PNA Clamping-Real Time Polymerase Chain Reaction , and Pyrosequencing Methods for the Detection of EGFR Mutations in Non-small_Cell_Lung_Carcinoma and the Correlation with Clinical Responses to EGFR Tyrosine Kinase Inhibitor Treatment .
23483659	0	Tyrosine	45,53	EGFR	40,44	Tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|compound|END_ENTITY	Immediate Versus Delayed Treatment with EGFR Tyrosine Kinase Inhibitors after First-line Therapy in Advanced Non-small-cell Lung CANCER .
25175686	0	Tyrosine	88,96	EGFR	83,87	Tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|compound|END_ENTITY	Design , Synthesis and Biological Evaluation of Quinoxalin-2 -LRB- 1H -RRB- - One Derivatives as EGFR Tyrosine Kinase Inhibitors .
25242668	0	Tyrosine	130,138	EGFR	125,129	Tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|compound|END_ENTITY	Activity of the EGFR-HER2 Dual Inhibitor Afatinib in EGFR-Mutant Lung Cancer Patients With Acquired Resistance to Reversible EGFR Tyrosine Kinase Inhibitors .
25303979	0	Tyrosine	78,86	EGFR	73,77	Tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|compound|END_ENTITY	Therapeutic Strategies Utilized in the Setting of Acquired Resistance to EGFR Tyrosine Kinase Inhibitors .
25486251	0	Tyrosine	48,56	EGFR	43,47	Tyrosine	EGFR	CHEBI:18186	13649(Tax:10090)	Chemical	Gene	Inhibitor|compound|START_ENTITY Inhibitor|compound|END_ENTITY	Amelioration of Hypercholesterolemia by an EGFR Tyrosine Kinase Inhibitor in Mice with Liver-Specific Knockout of Mig-6 .
25503781	0	Tyrosine	17,25	EGFR	12,16	Tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|compound|END_ENTITY	Efficacy of EGFR Tyrosine Kinase Inhibitors in Non-Small-Cell Lung Cancer Patients with/without EGFR-Mutation : Evidence Based on Recent Phase III Randomized Trials .
25897154	0	Tyrosine	136,144	EGFR	131,135	Tyrosine	EGFR	D014443	1956	Chemical	Gene	Chemotherapy|compound|START_ENTITY Chemotherapy|compound|END_ENTITY	Impact of Specific Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- Mutations and Clinical Characteristics on Outcomes After Treatment With EGFR Tyrosine Kinase Inhibitors Versus Chemotherapy in EGFR-Mutant Lung Cancer : A Meta-Analysis .
26001141	0	Tyrosine	133,141	EGFR	128,132	Tyrosine	EGFR	D014443	1956	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|compound|END_ENTITY	The BIM Deletion Polymorphism and its Clinical Implication in Patients with EGFR-Mutant Non-Small-Cell Lung Cancer Treated with EGFR Tyrosine Kinase Inhibitors .
26001141	0	Tyrosine	133,141	EGFR	128,132	Tyrosine	EGFR	D014443	1956	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|compound|END_ENTITY	The BIM Deletion Polymorphism and its Clinical Implication in Patients with EGFR-Mutant Non-Small-Cell Lung Cancer Treated with EGFR Tyrosine Kinase Inhibitors .
26058074	0	Tyrosine	22,30	EGFR	17,21	Tyrosine	EGFR	D014443	1956	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|compound|END_ENTITY	The Next Wave of EGFR Tyrosine Kinase Inhibitors Enter the Clinic .
26181354	0	Tyrosine	133,141	EGFR	128,132	Tyrosine	EGFR	D014443	1956	Chemical	Gene	Domain|compound|START_ENTITY Domain|compound|END_ENTITY	Acquired Resistance of EGFR-Mutant Lung Cancer to a T790M-Specific EGFR Inhibitor : Emergence of a Third Mutation -LRB- C797S -RRB- in the EGFR Tyrosine Kinase Domain .
26187773	0	Tyrosine	63,71	EGFR	58,62	Tyrosine	EGFR	D014443	1956	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|compound|END_ENTITY	Expert Consensus on the Management of Adverse Events from EGFR Tyrosine Kinase Inhibitors in the UK .
26187773	0	Tyrosine	63,71	EGFR	58,62	Tyrosine	EGFR	D014443	1956	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|compound|END_ENTITY	Expert Consensus on the Management of Adverse Events from EGFR Tyrosine Kinase Inhibitors in the UK .
26282169	0	Tyrosine	111,119	EGFR	106,110	Tyrosine	EGFR	D014443	1956	Chemical	Gene	Inhibition|compound|START_ENTITY Inhibition|compound|END_ENTITY	Intratumoral Heterogeneity in EGFR-Mutant NSCLC Results in Divergent Resistance Mechanisms in Response to EGFR Tyrosine Kinase Inhibition .
26301867	0	Tyrosine	81,89	EGFR	66,70	Tyrosine	EGFR	D014443	1956	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|compound|END_ENTITY	Mechanism of Resistance and Novel Targets Mediating Resistance to EGFR and c-Met Tyrosine Kinase Inhibitors in Non-Small_Cell_Lung_Cancer .
26334752	0	Tyrosine	58,66	EGFR	53,57	Tyrosine	EGFR	D014443	1956	Chemical	Gene	Inhibition|compound|START_ENTITY Inhibition|compound|END_ENTITY	Impact of Concurrent PIK3CA Mutations on Response to EGFR Tyrosine Kinase Inhibition in EGFR-Mutant Lung Cancers and on Prognosis in Oncogene-Driven Lung Adenocarcinomas .
26439264	0	Tyrosine	78,86	EGFR	73,77	Tyrosine	EGFR	D014443	1956	Chemical	Gene	Gefitinib|compound|START_ENTITY Gefitinib|compound|END_ENTITY	Contrasting Effects of the Cytotoxic Anticancer Drug Gemcitabine and the EGFR Tyrosine Kinase Inhibitor Gefitinib on NK Cell-Mediated Cytotoxicity via Regulation of NKG2D Ligand in Non-Small-Cell Lung_Cancer Cells .
26633023	0	Tyrosine	60,68	EGFR	55,59	Tyrosine	EGFR	D014443	1956	Chemical	Gene	Kinase|compound|START_ENTITY Kinase|compound|END_ENTITY	Discovery of Potent Antiproliferative Agents Targeting EGFR Tyrosine Kinase Based on the Pyrido -LSB- 3 ' ,2 ' :4,5 -RSB- thieno -LSB- 3,2-d -RSB- pyrimidin-4-amine Scaffold .
26667342	0	Tyrosine	33,41	EGFR	28,32	Tyrosine	EGFR	D014443	1956	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|compound|END_ENTITY	Mechanisms of Resistance to EGFR Tyrosine Kinase Inhibitors and Therapeutic Approaches : An Update .
26719155	0	Tyrosine	112,120	EGFR	193,197	Tyrosine	EGFR	D014443	1956	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|nmod|Patients Patients|nmod|Mutations Mutations|compound|END_ENTITY	Serum Neuron-Specific_Enolase Levels Predict the Efficacy of First-Line Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- Tyrosine Kinase Inhibitors in Patients With Non-Small_Cell_Lung_Cancer Harboring EGFR Mutations .
26933418	0	Tyrosine	119,127	EGFR	114,118	Tyrosine	EGFR	D014443	1956	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|compound|END_ENTITY	RRx-001-Induced Tumor Necrosis and Immune Cell Infiltration in an EGFR Mutation-Positive NSCLC with Resistance to EGFR Tyrosine Kinase Inhibitors : A Case Report .
26958085	0	Tyrosine	41,49	EGFR	36,40	Tyrosine	EGFR	D014443	1956	Chemical	Gene	Inhibitor|compound|START_ENTITY Inhibitor|compound|END_ENTITY	Ganoderma lucidum Combined with the EGFR Tyrosine Kinase Inhibitor , Erlotinib Synergize to Reduce Inflammatory Breast Cancer Progression .
26961971	0	Tyrosine	16,24	EGFR	11,15	Tyrosine	EGFR	D014443	1956	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|compound|END_ENTITY	The Use of EGFR Tyrosine Kinase Inhibitors in EGFR Wild-Type Non-Small-Cell Lung_Cancer .
27077907	0	Tyrosine	75,83	EGFR	70,74	Tyrosine	EGFR	D014443	1956	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|compound|END_ENTITY	Association of BIM Deletion Polymorphism With Intrinsic Resistance to EGFR Tyrosine Kinase Inhibitors in Patients With Lung_Adenocarcinoma .
25681440	0	Tyrosine	34,42	ERBB2	80,85	Tyrosine	ERBB2	CHEBI:18186	2064	Chemical	Gene	Axis|compound|START_ENTITY Essential|nsubj|Axis Essential|nmod|Signaling Signaling|compound|END_ENTITY	A Novel Phosphatidic_Acid-Protein Tyrosine Phosphatase D2 Axis is Essential for ERBB2 Signaling in Mammary Epithelial Cells .
26072398	0	Tyrosine	37,45	ERBB2	22,27	Tyrosine	ERBB2	D014443	2064	Chemical	Gene	Kinase|compound|START_ENTITY Kinase|compound|END_ENTITY	Aptamer Targeting the ERBB2 Receptor Tyrosine Kinase for Applications in Tumor Therapy .
21647358	0	Tyrosine	0,8	EWS	100,103	Tyrosine	EWS	CHEBI:18186	2130	Chemical	Gene	Phosphorylation|compound|START_ENTITY Phosphorylation|nmod|Protein Protein|compound|END_ENTITY	Tyrosine Phosphorylation in the C-Terminal Nuclear Localization and Retention Signal -LRB- C-NLS -RRB- of the EWS Protein .
25286141	0	Tyrosine	35,43	EphA1	20,25	Tyrosine	EphA1	CHEBI:18186	2041	Chemical	Gene	Domain|compound|START_ENTITY Domain|compound|END_ENTITY	Dimerization of the EphA1 Receptor Tyrosine Kinase Transmembrane Domain : Insights into the Mechanism of Receptor Activation .
26589795	0	Tyrosine	24,32	EphB2	40,45	Tyrosine	EphB2	D014443	2048	Chemical	Gene	Depletion|compound|START_ENTITY Depletion|compound|END_ENTITY	Increasing the Receptor Tyrosine Kinase EphB2 Prevents Amyloid-b-induced Depletion of Cell-Surface Glutamate Receptors by a Mechanism that Requires EphB2 's PDZ-binding Motif and Neuronal Activity .
20008850	0	Tyrosine	47,55	Epidermal_Growth_Factor_Receptor	14,46	Tyrosine	Epidermal Growth Factor Receptor	CHEBI:18186	1956	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|compound|END_ENTITY	Resistance to Epidermal_Growth_Factor_Receptor Tyrosine Kinase Inhibitors in Non-Small_Cell_Lung_Cancer .
22550402	0	Tyrosine	80,88	Epidermal_Growth_Factor_Receptor	47,79	Tyrosine	Epidermal Growth Factor Receptor	CHEBI:18186	1956	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|compound|END_ENTITY	The Evolving Role of Maintenance Therapy Using Epidermal_Growth_Factor_Receptor Tyrosine Kinase Inhibitors -LRB- EGFR TKIs -RRB- in the Management of Advanced Non-Small-Cell_Lung_Cancer .
23074402	0	Tyrosine	102,110	Epidermal_Growth_Factor_Receptor	0,32	Tyrosine	Epidermal Growth Factor Receptor	D014443	1956	Chemical	Gene	Drugs|compound|START_ENTITY Response|nmod|Drugs Prediction|nmod|Response Testing|nmod|Prediction Testing|compound|END_ENTITY	Epidermal_Growth_Factor_Receptor Mutation -LRB- EGFR -RRB- Testing for Prediction of Response to EGFR-Targeting Tyrosine Kinase Inhibitor -LRB- TKI -RRB- Drugs in Patients with Advanced_Non-Small-Cell_Lung_Cancer : An Evidence-Based Analysis .
23864840	0	Tyrosine	93,101	Epidermal_Growth_Factor_Receptor	60,92	Tyrosine	Epidermal Growth Factor Receptor	CHEBI:18186	1956	Chemical	Gene	Inhibitor|compound|START_ENTITY Inhibitor|compound|END_ENTITY	Treatment of Non-small_Cell_Lung_Carcinoma after Failure of Epidermal_Growth_Factor_Receptor Tyrosine Kinase Inhibitor .
25006755	0	Tyrosine	20,28	Epidermal_Growth_Factor_Receptor	74,106	Tyrosine	Epidermal Growth Factor Receptor	CHEBI:18186	1956	Chemical	Gene	Activity|compound|START_ENTITY Activity|nmod|END_ENTITY	Rapid Evaluation of Tyrosine Kinase Activity of Membrane-Integrated Human Epidermal_Growth_Factor_Receptor Using the Yeast Gy Recruitment System .
25036571	0	Tyrosine	123,131	Epidermal_Growth_Factor_Receptor	90,122	Tyrosine	Epidermal Growth Factor Receptor	CHEBI:18186	1956	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|compound|END_ENTITY	Nomogram Predicting Clinical Outcomes in Non-small_Cell_Lung_Cancer Patients Treated with Epidermal_Growth_Factor_Receptor Tyrosine Kinase Inhibitors .
25247337	0	Tyrosine	101,109	Epidermal_Growth_Factor_Receptor	61,93	Tyrosine	Epidermal Growth Factor Receptor	CHEBI:18186	1956	Chemical	Gene	Inhibitor|compound|START_ENTITY END_ENTITY|dep|Inhibitor	Efficacy of the Irreversible ErbB Family Blocker Afatinib in Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- Tyrosine Kinase Inhibitor -LRB- TKI -RRB- - Pretreated Non-Small-Cell Lung Cancer Patients with Brain Metastases or Leptomeningeal_Disease .
25647830	0	Tyrosine	49,57	Epidermal_Growth_Factor_Receptor	126,158	Tyrosine	Epidermal Growth Factor Receptor	CHEBI:18186	1956	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|nmod|END_ENTITY	The Efficacy of Epidermal_Growth_Factor_Receptor Tyrosine Kinase Inhibitors in Non-Small_Cell_Lung_Cancer Harboring Wild-type Epidermal_Growth_Factor_Receptor : A Meta-analysis of 25 RCTs .
25647830	0	Tyrosine	49,57	Epidermal_Growth_Factor_Receptor	16,48	Tyrosine	Epidermal Growth Factor Receptor	CHEBI:18186	1956	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|compound|END_ENTITY	The Efficacy of Epidermal_Growth_Factor_Receptor Tyrosine Kinase Inhibitors in Non-Small_Cell_Lung_Cancer Harboring Wild-type Epidermal_Growth_Factor_Receptor : A Meta-analysis of 25 RCTs .
25687850	0	Tyrosine	148,156	Epidermal_Growth_Factor_Receptor	108,140	Tyrosine	Epidermal Growth Factor Receptor	CHEBI:18186	1956	Chemical	Gene	Inhibitor|compound|START_ENTITY Failure|nsubj|Inhibitor Failure|nmod|END_ENTITY	Pemetrexed Singlet versus Nonpemetrexed-Based Platinum Doublet as Second-Line Chemotherapy after First-Line Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- Tyrosine Kinase Inhibitor Failure in Non-Small_Cell_Lung_Cancer Patients with EGFR Mutations .
25870087	0	Tyrosine	146,154	Epidermal_Growth_Factor_Receptor	113,145	Tyrosine	Epidermal Growth Factor Receptor	D014443	1956	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|compound|END_ENTITY	Phase I/II Study of HSP90 Inhibitor AUY922 and Erlotinib for EGFR-Mutant Lung Cancer With Acquired Resistance to Epidermal_Growth_Factor_Receptor Tyrosine Kinase Inhibitors .
25897154	0	Tyrosine	136,144	Epidermal_Growth_Factor_Receptor	19,51	Tyrosine	Epidermal Growth Factor Receptor	D014443	1956	Chemical	Gene	Chemotherapy|compound|START_ENTITY Impact|nmod|Chemotherapy Impact|nmod|Mutations Mutations|compound|END_ENTITY	Impact of Specific Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- Mutations and Clinical Characteristics on Outcomes After Treatment With EGFR Tyrosine Kinase Inhibitors Versus Chemotherapy in EGFR-Mutant Lung Cancer : A Meta-Analysis .
26124334	0	Tyrosine	17,25	Epidermal_Growth_Factor_Receptor	113,145	Tyrosine	Epidermal Growth Factor Receptor	D014443	1956	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|nmod|Patients Patients|nmod|Mutations Mutations|compound|END_ENTITY	Effectiveness of Tyrosine Kinase Inhibitors in Japanese Patients with Non-small_Cell_Lung_Cancer Harboring Minor Epidermal_Growth_Factor_Receptor Mutations : Results from a Multicenter Retrospective Study -LRB- HANSHIN Oncology Group 0212 -RRB- .
26266520	0	Tyrosine	24,32	Epidermal_Growth_Factor_Receptor	111,143	Tyrosine	Epidermal Growth Factor Receptor	D014443	1956	Chemical	Gene	Inhibitors|compound|START_ENTITY Activity|nmod|Inhibitors Activity|nmod|Mutations Mutations|compound|END_ENTITY	Antitumoral Activity of Tyrosine Kinase Inhibitors in Patients with Non-small_Cell_Lung_Cancer Harbouring Rare Epidermal_Growth_Factor_Receptor Mutations .
26313252	0	Tyrosine	146,154	Epidermal_Growth_Factor_Receptor	113,145	Tyrosine	Epidermal Growth Factor Receptor	D014443	1956	Chemical	Gene	Inhibitor|compound|START_ENTITY Inhibitor|compound|END_ENTITY	Discovery and Evaluation of Clinical Candidate AZD3759 , a Potent , Oral Active , Central Nervous System-Penetrant , Epidermal_Growth_Factor_Receptor Tyrosine Kinase Inhibitor .
26334749	0	Tyrosine	33,41	Epidermal_Growth_Factor_Receptor	0,32	Tyrosine	Epidermal Growth Factor Receptor	D014443	1956	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|compound|END_ENTITY	Epidermal_Growth_Factor_Receptor Tyrosine Kinase Inhibitors for Non-Small-Cell Lung Cancer Patients with Leptomeningeal_Carcinomatosis .
26364032	0	Tyrosine	48,56	Epidermal_Growth_Factor_Receptor	15,47	Tyrosine	Epidermal Growth Factor Receptor	D014443	1956	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|compound|END_ENTITY	Generations of Epidermal_Growth_Factor_Receptor Tyrosine Kinase Inhibitors : Perils and Progress .
26528827	0	Tyrosine	10,18	Epidermal_Growth_Factor_Receptor	85,117	Tyrosine	Epidermal Growth Factor Receptor	D014443	1956	Chemical	Gene	Non-Small_Cell_Lung_Cancer|compound|START_ENTITY Targeting|dobj|Non-Small_Cell_Lung_Cancer Targeting|nmod|Degradation Degradation|compound|END_ENTITY	Targeting Tyrosine Kinase Inhibitor-Resistant Non-Small_Cell_Lung_Cancer by Inducing Epidermal_Growth_Factor_Receptor Degradation via Methionine 790 Oxidation .
26683939	0	Tyrosine	220,228	Epidermal_Growth_Factor_Receptor	187,219	Tyrosine	Epidermal Growth Factor Receptor	D014443	1956	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|compound|END_ENTITY	Baseline , Trend , and Normalization of Carcinoembryonic_Antigen as Prognostic Factors in Epidermal_Growth_Factor_Receptor-Mutant Nonsmall Cell Lung Cancer Patients Treated With First-Line Epidermal_Growth_Factor_Receptor Tyrosine Kinase Inhibitors .
26719155	0	Tyrosine	112,120	Epidermal_Growth_Factor_Receptor	72,104	Tyrosine	Epidermal Growth Factor Receptor	D014443	1956	Chemical	Gene	Inhibitors|compound|START_ENTITY Predict|dep|Inhibitors Predict|dep|Efficacy Efficacy|nmod|END_ENTITY	Serum Neuron-Specific_Enolase Levels Predict the Efficacy of First-Line Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- Tyrosine Kinase Inhibitors in Patients With Non-Small_Cell_Lung_Cancer Harboring EGFR Mutations .
26725853	0	Tyrosine	33,41	Epidermal_Growth_Factor_Receptor	0,32	Tyrosine	Epidermal Growth Factor Receptor	D014443	1956	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|compound|END_ENTITY	Epidermal_Growth_Factor_Receptor Tyrosine Kinase Inhibitors in Advanced_Squamous_Cell_Lung_Cancer .
26778441	0	Tyrosine	23,31	Epidermal_Growth_Factor_Receptor	129,161	Tyrosine	Epidermal Growth Factor Receptor	D014443	1956	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|nmod|Therapy Therapy|nmod|Lung_Cancer Lung_Cancer|nmod|Mutations Mutations|compound|END_ENTITY	Pharmacologic Costs of Tyrosine Kinase Inhibitors in First-Line Therapy for Advanced Non-Small-Cell Lung_Cancer With Activating Epidermal_Growth_Factor_Receptor Mutations : A Review of Pivotal Phase III Randomized Controlled Trials .
26790969	0	Tyrosine	72,80	Epidermal_Growth_Factor_Receptor	39,71	Tyrosine	Epidermal Growth Factor Receptor	D014443	1956	Chemical	Gene	Administration|compound|START_ENTITY Administration|compound|END_ENTITY	Clinical Characteristics and Continued Epidermal_Growth_Factor_Receptor Tyrosine Kinase Inhibitor Administration in EGFR-mutated Non-Small_Cell_Lung_Cancer with Skeletal Metastasis .
26859739	0	Tyrosine	62,70	Epidermal_Growth_Factor_Receptor	29,61	Tyrosine	Epidermal Growth Factor Receptor	D014443	1956	Chemical	Gene	Therapy|compound|START_ENTITY Therapy|compound|END_ENTITY	The Efficacy of Single-Agent Epidermal_Growth_Factor_Receptor Tyrosine Kinase Inhibitor Therapy in Biologically Selected Patients with Non-Small-Cell_Lung_Cancer : A Meta-Analysis of 19 Randomized Controlled Trials .
26894507	0	Tyrosine	209,217	Epidermal_Growth_Factor_Receptor	176,208	Tyrosine	Epidermal Growth Factor Receptor	D014443	1956	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|compound|END_ENTITY	Antacid Use and De Novo Brain Metastases in Patients with Epidermal_Growth_Factor_Receptor-Mutant Non-Small_Cell_Lung_Cancer Who Were Treated Using First-Line First-Generation Epidermal_Growth_Factor_Receptor Tyrosine Kinase Inhibitors .
26926157	0	Tyrosine	81,89	Epidermal_Growth_Factor_Receptor	48,80	Tyrosine	Epidermal Growth Factor Receptor	D014443	13649(Tax:10090)	Chemical	Gene	Inhibitor|compound|START_ENTITY Inhibitor|compound|END_ENTITY	Cetuximab Inhibits T790M-Mediated Resistance to Epidermal_Growth_Factor_Receptor Tyrosine Kinase Inhibitor in a Lung_Adenocarcinoma Patient-Derived Xenograft Mouse Model .
26943330	0	Tyrosine	105,113	Epidermal_Growth_Factor_Receptor	72,104	Tyrosine	Epidermal Growth Factor Receptor	D014443	1956	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|compound|END_ENTITY	Blockade of Hedgehog Signaling Synergistically Increases Sensitivity to Epidermal_Growth_Factor_Receptor Tyrosine Kinase Inhibitors in Non-Small-Cell Lung Cancer Cell Lines .
10953014	0	Tyrosine	0,8	Eps15	28,33	Tyrosine	Eps15	CHEBI:18186	2060	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of Eps15 is required for ligand-regulated , but not constitutive , endocytosis .
25472645	0	Tyrosine	109,117	Era	102,105	Tyrosine	Era	CHEBI:18186	26284	Chemical	Gene	Inhibitors|compound|START_ENTITY END_ENTITY|nmod|Inhibitors	Surgical Resection Does Not Improve Survival in Patients with Renal_Metastases to the Pancreas in the Era of Tyrosine Kinase Inhibitors .
21701703	0	Tyrosine	107,115	ErbB	83,87	Tyrosine	ErbB	CHEBI:18186	1956	Chemical	Gene	Kinases|compound|START_ENTITY Family|nmod|Kinases Family|compound|END_ENTITY	Analysis of Somatic Mutations in Cancer : Molecular Mechanisms of Activation in the ErbB Family of Receptor Tyrosine Kinases .
25427151	0	Tyrosine	89,97	ErbB	65,69	Tyrosine	ErbB	CHEBI:18186	1956	Chemical	Gene	Kinases|compound|START_ENTITY Family|nmod|Kinases Family|compound|END_ENTITY	Structure-Based Network Analysis of Activation Mechanisms in the ErbB Family of Receptor Tyrosine Kinases : The Regulatory Spine Residues Are Global Mediators of Structural Stability and Allosteric Interactions .
24709902	0	Tyrosine	77,85	ErbB2	62,67	Tyrosine	ErbB2	CHEBI:18186	2064	Chemical	Gene	Kinase|compound|START_ENTITY Turns|nsubj|Kinase Turns|nmod|Receptor Receptor|compound|END_ENTITY	When Good Turns Bad : Regulation of Invasion and Metastasis by ErbB2 Receptor Tyrosine Kinase .
17646177	0	Tyrosine	0,8	ErbB4	28,33	Tyrosine	ErbB4	CHEBI:18186	2066	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of ErbB4 is enhanced by PSD95 and repressed by protein tyrosine phosphatase receptor type Z. Protein tyrosine phosphatase receptor type Z -LRB- Ptprz/PTPzeta/RPTPbeta -RRB- is a receptor-like protein tyrosine phosphatase -LRB- RPTP -RRB- preferentially expressed in the brain .
9016763	0	Tyrosine	0,8	ErbB4	28,33	Tyrosine	ErbB4	CHEBI:18186	2066	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of ErbB4 is stimulated by aurintricarboxylic_acid in human neuroblastoma SH-SY5Y cells .
25053825	0	Tyrosine	63,71	FLT3	58,62	Tyrosine	FLT3	CHEBI:18186	2322	Chemical	Gene	Inhibitor|compound|START_ENTITY Inhibitor|compound|END_ENTITY	BET Protein Antagonist JQ1 Is Synergistically Lethal with FLT3 Tyrosine Kinase Inhibitor -LRB- TKI -RRB- and Overcomes Resistance to FLT3-TKI in AML Cells Expressing FLT-ITD .
26111466	0	Tyrosine	5,13	FLT3	0,4	Tyrosine	FLT3	D014443	2322	Chemical	Gene	Inhibition|compound|START_ENTITY Inhibition|compound|END_ENTITY	FLT3 Tyrosine Kinase Inhibition as a Paradigm for Targeted Drug Development in Acute_Myeloid_Leukemia .
26785334	0	Tyrosine	118,126	FLT3	113,117	Tyrosine	FLT3	D014443	2322	Chemical	Gene	Post-Transplantation|compound|START_ENTITY Post-Transplantation|compound|END_ENTITY	Allogeneic Hematopoietic Stem Cell Transplantation in FLT3-ITD-Positive Acute_Myelogenous_Leukemia : The Role for FLT3 Tyrosine Kinase Inhibitors Post-Transplantation .
15569927	0	Tyrosine	0,8	FRS2alpha	34,43	Tyrosine	FRS2alpha	CHEBI:18186	327826(Tax:10090)	Chemical	Gene	sites|amod|START_ENTITY sites|nmod|END_ENTITY	Tyrosine phosphorylation sites on FRS2alpha responsible for Shp2 recruitment are critical for induction of lens and retina .
25884760	0	Tyrosine	14,22	FYN	57,60	Tyrosine	FYN	D014443	2534	Chemical	Gene	Involve|compound|START_ENTITY END_ENTITY|nsubj|Involve	Neuroblastoma Tyrosine Kinase Signaling Networks Involve FYN and LYN in Endosomes and Lipid Rafts .
1701792	0	Tyrosine	0,8	Fc_gamma_RIII	32,45	Tyrosine	Fc gamma RIII	CHEBI:18186	2214	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of the Fc_gamma_RIII -LRB- CD16 -RRB- : zeta complex in human natural killer cells .
11536198	0	Tyrosine	0,8	Fyn	43,46	Tyrosine	Fyn	CHEBI:18186	2534	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|p190_RhoGAP p190_RhoGAP|nmod|END_ENTITY	Tyrosine phosphorylation of p190_RhoGAP by Fyn regulates oligodendrocyte differentiation .
11677266	0	Tyrosine	0,8	Fyn	62,65	Tyrosine	Fyn	CHEBI:18186	2534	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|receptors receptors|nmod|END_ENTITY	Tyrosine phosphorylation of ionotropic glutamate receptors by Fyn or Src differentially modulates their susceptibility to calpain and enhances their binding to spectrin and PSD-95 .
12083796	3	Tyrosine	769,777	Fyn	844,847	Tyrosine	Src	CHEBI:18186	20779(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY apparent|nsubj|phosphorylation apparent|nmod|cells cells|acl|deficient deficient|nmod|Yes Yes|appos|END_ENTITY	Tyrosine phosphorylation of SSeCKS was apparent in cells deficient in Src , Fyn , Yes , or Abl tyrosine kinases or in NIH3T3 cells expressing a temperature-sensitive v-Src allele , but not in FAK-deficient embryo fibroblasts .
21097520	0	Tyrosine	0,8	Fyn	52,55	Tyrosine	Fyn	CHEBI:18186	2534	Chemical	Gene	phosphorylation|amod|START_ENTITY controls|nsubj|phosphorylation controls|dobj|export export|nmod|END_ENTITY	Tyrosine phosphorylation controls nuclear export of Fyn , allowing Nrf2 activation of cytoprotective gene expression .
21692989	0	Tyrosine	0,8	Fyn	64,67	Tyrosine	Fyn	CHEBI:18186	2534	Chemical	Gene	phosphorylation|amod|START_ENTITY regulates|nsubj|phosphorylation regulates|nmod|domains domains|compound|END_ENTITY	Tyrosine phosphorylation of tau regulates its interactions with Fyn SH2 domains , but not SH3 domains , altering the cellular localization of tau .
25225878	0	Tyrosine	62,70	Fyn	58,61	Tyrosine	Fyn	CHEBI:18186	2534	Chemical	Gene	Kinase|compound|START_ENTITY Kinase|compound|END_ENTITY	Probing the Interaction between U24 and the SH3 Domain of Fyn Tyrosine Kinase .
26382759	0	Tyrosine	94,102	Fyn	90,93	Tyrosine	Fyn	D014443	2534	Chemical	Gene	Kinase|compound|START_ENTITY Kinase|compound|END_ENTITY	Differential Modulation of Fast Inactivation in Cardiac Sodium Channel Splice Variants by Fyn Tyrosine Kinase .
9104812	0	Tyrosine	0,8	Fyn	61,64	Tyrosine	Fyn	CHEBI:18186	2534	Chemical	Gene	phosphorylation|amod|START_ENTITY regulated|nsubjpass|phosphorylation regulated|nmod|END_ENTITY	Tyrosine phosphorylation of Pyk2 is selectively regulated by Fyn during TCR signaling .
16725308	0	Tyrosine	0,8	G-protein-coupled-receptor_kinase_2	28,63	Tyrosine	G-protein-coupled-receptor kinase 2	CHEBI:18186	156	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of G-protein-coupled-receptor_kinase_2 -LRB- GRK2 -RRB- by c-Src modulates its interaction with Galphaq .
25381250	0	Tyrosine	34,42	GRB2	16,20	Tyrosine	GRB2	CHEBI:18186	14784(Tax:10090)	Chemical	Gene	Activation|compound|START_ENTITY Promotes|dobj|Activation Promotes|nsubj|END_ENTITY	Adaptor Protein GRB2 Promotes Src Tyrosine Kinase Activation and Podosomal Organization by Protein-tyrosine Phosphatase in Osteoclasts .
8940106	0	Tyrosine	0,8	GSalpha	28,35	Tyrosine	GSalpha	CHEBI:18186	2778	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of GSalpha and inhibition of bradykinin-induced activation of the cyclic_AMP pathway in A431 cells by epidermal_growth_factor_receptor .
14976558	0	Tyrosine	0,8	GluR2	28,33	Tyrosine	GluR2	CHEBI:18186	2891	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of GluR2 is required for insulin-stimulated AMPA receptor endocytosis and LTD. .
20973951	0	Tyrosine	0,8	Grb14	28,33	Tyrosine	Grb14	CHEBI:18186	2888	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of Grb14 by Tie2 .
11726515	0	Tyrosine	0,8	Grb2	28,32	Tyrosine	Grb2	CHEBI:18186	2885	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of Grb2 by Bcr/Abl and epidermal_growth_factor_receptor : a novel regulatory mechanism for tyrosine kinase signaling .
19273609	0	Tyrosine	0,8	Grb2	28,32	Tyrosine	Grb2	CHEBI:18186	2885	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of Grb2 : role in prolactin/epidermal _ growth_factor cross talk in mammary epithelial cell growth and differentiation .
20398064	0	Tyrosine	0,8	Grb2	117,121	Tyrosine	Grb2	CHEBI:18186	2885	Chemical	Gene	phosphorylation|amod|START_ENTITY subtype|nsubj|phosphorylation subtype|nmod|END_ENTITY	Tyrosine phosphorylation of R3 subtype receptor-type protein tyrosine phosphatases and their complex formations with Grb2 or Fyn .
9185541	0	Tyrosine	0,8	Grb2	70,74	Tyrosine	Grb2	CHEBI:18186	2885	Chemical	Gene	phosphorylation|amod|START_ENTITY mediates|nsubj|phosphorylation mediates|xcomp|binding binding|nsubj|END_ENTITY	Tyrosine phosphorylation of nicotinic acetylcholine receptor mediates Grb2 binding .
19234442	0	Tyrosine	0,8	H2AX	30,34	Tyrosine	H2AX	CHEBI:18186	3014	Chemical	Gene	dephosphorylation|amod|START_ENTITY dephosphorylation|nmod|END_ENTITY	Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions .
21637380	0	Tyrosine	38,46	HER2	33,37	Tyrosine	HER2	CHEBI:18186	2064	Chemical	Gene	Kinase|compound|START_ENTITY Kinase|compound|END_ENTITY	The Functional Crosstalk between HER2 Tyrosine Kinase and TGF-b Signaling in Breast_Cancer_Malignancy .
25346782	0	Tyrosine	83,91	HER2	69,73	Tyrosine	HER2	D014443	2064	Chemical	Gene	Kinase|compound|START_ENTITY Kinase|compound|END_ENTITY	Investigating Molecular Mechanisms of Activation and Mutation of the HER2 Receptor Tyrosine Kinase through Computational Modeling and Simulation .
18498770	0	Tyrosine	0,8	HPK1	28,32	Tyrosine	HPK1	CHEBI:18186	292763(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of HPK1 by activated Src promotes ischemic_brain_injury in rat hippocampal CA1 region .
25444929	0	Tyrosine	0,8	HSC70	28,33	Tyrosine	HSC70	D014443	15481(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of HSC70 and its interaction with RFC mediates methotrexate resistance in murine L1210 leukemia cells .
12890735	0	Tyrosine	0,8	HSP-90	28,34	Tyrosine	HSP-90	CHEBI:18186	3320	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of HSP-90 during mammalian sperm capacitation .
25687758	0	Tyrosine	65,73	HSP60	93,98	Tyrosine	HSP60	CHEBI:18186	3329	Chemical	Gene	Phosphorylation|compound|START_ENTITY Phosphorylation|nmod|END_ENTITY	PRL-3 Mediates the Protein Maturation of ULBP2 by Regulating the Tyrosine Phosphorylation of HSP60 .
12869560	0	Tyrosine	0,8	HSP90	28,33	Tyrosine	HSP90	CHEBI:18186	3320	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of HSP90 within the P2X7_receptor complex negatively regulates P2X7_receptors .
24106086	0	Tyrosine	0,8	HuR	28,31	Tyrosine	HuR	D014443	1994	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of HuR by JAK3 triggers dissociation and degradation of HuR target mRNAs .
12707358	0	Tyrosine	0,8	I-kappa_B_kinase_alpha	28,50	Tyrosine	I-kappa B kinase alpha	CHEBI:18186	1147	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of I-kappa_B_kinase_alpha / beta by protein kinase C-dependent c-Src activation is involved in TNF-alpha-induced cyclooxygenase-2 expression .
12073931	0	Tyrosine	0,8	IA-2	35,39	Tyrosine	IA-2	CHEBI:18186	5798	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Tyrosine phosphatase-like protein -LRB- IA-2 -RRB- and glutamic_acid decarboxylase -LRB- GAD65 -RRB- autoantibodies : a study of Chinese patients with diabetes_mellitus .
23094148	0	Tyrosine	105,113	IGF-I	90,95	Tyrosine	IGF-I	CHEBI:18186	3479	Chemical	Gene	Kinase|compound|START_ENTITY Kinase|compound|END_ENTITY	Estrogen Regulates MAPK-Related Genes through Genomic and Nongenomic Interactions between IGF-I Receptor Tyrosine Kinase and Estrogen_Receptor-Alpha Signaling Pathways in Human Uterine Leiomyoma Cells .
11279262	0	Tyrosine	0,8	IRS-1	58,63	Tyrosine	IRS-1	CHEBI:18186	25467(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of insulin_receptor_substrate-1 -LRB- IRS-1 -RRB- by oxidant stress in cerebellar granule neurons : modulation by N-methyl-D-aspartate through calcineurin activity .
8797825	0	Tyrosine	0,8	I_kappa_B-alpha	28,43	Tyrosine	I kappa B-alpha	CHEBI:18186	4792	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of I_kappa_B-alpha activates NF-kappa_B without proteolytic degradation of I_kappa_B-alpha .
12429743	0	Tyrosine	0,8	I_kappa_B_alpha	28,43	Tyrosine	I kappa B alpha	CHEBI:18186	18035(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of I_kappa_B_alpha activates NF_kappa_B through a redox-regulated and c-Src-dependent mechanism following hypoxia/reoxygenation .
26435211	0	Tyrosine	8,16	Insulin	46,53	Tyrosine	Insulin	D014443	3630	Chemical	Gene	Phosphatases|nsubj|START_ENTITY Phosphatases|nmod|END_ENTITY	Protein Tyrosine Phosphatases in Hypothalamic Insulin and Leptin Signaling .
26881241	0	Tyrosine	0,8	Insulin	28,35	Tyrosine	Insulin	D014443	3630	Chemical	Gene	Associated|nsubj|START_ENTITY Associated|nmod|Resistance Resistance|compound|END_ENTITY	Tyrosine Is Associated with Insulin Resistance in Longitudinal Metabolomic Profiling of Obese Children .
25824741	0	Tyrosine	59,67	JAK2	54,58	Tyrosine	JAK2	CHEBI:18186	3717	Chemical	Gene	Kinase|compound|START_ENTITY Kinase|compound|END_ENTITY	Methylated Alteration of SHP1 Complements Mutation of JAK2 Tyrosine Kinase in Patients with Myeloproliferative_Neoplasm .
24106086	0	Tyrosine	0,8	JAK3	35,39	Tyrosine	JAK3	D014443	3718	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|HuR HuR|nmod|END_ENTITY	Tyrosine phosphorylation of HuR by JAK3 triggers dissociation and degradation of HuR target mRNAs .
15143188	0	Tyrosine	0,8	Jak2	28,32	Tyrosine	Jak2	CHEBI:18186	3717	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of Jak2 in the JH2 domain inhibits cytokine signaling .
10408379	0	Tyrosine	0,8	Janus_kinase_1	43,57	Tyrosine	Janus kinase 1	CHEBI:18186	3716	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation and activation of Janus_kinase_1 and STAT3 by sublytic C5b-9 complement complex in aortic endothelial cells .
26217035	0	Tyrosine	15,23	JunB	43,47	Tyrosine	JunB	D014443	3726	Chemical	Gene	Phosphorylation|compound|START_ENTITY Phosphorylation|nmod|END_ENTITY	c-Abl-mediated Tyrosine Phosphorylation of JunB is Required for Adriamycin-induced Expression of p21 .
23645696	4	Tyrosine	585,593	KAP1	613,617	Tyrosine	KAP1	CHEBI:18186	10155	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of KAP1 is induced by several tyrosine kinases , such as Src , Lyn , Abl , and Brk .
25550534	0	Tyrosine	36,44	KGFR	31,35	Tyrosine	KGFR	CHEBI:18186	2263	Chemical	Gene	Inhibitor|compound|START_ENTITY Inhibitor|compound|END_ENTITY	Oncolytic Potential of a Novel KGFR Tyrosine Kinase Inhibitor Using a KGFR-selective Breast Cancer Xenograft Model .
25237194	0	Tyrosine	10,18	Kindlin-2	0,9	Tyrosine	Kindlin-2	CHEBI:18186	218952(Tax:10090)	Chemical	Gene	Phosphorylation|compound|START_ENTITY Phosphorylation|compound|END_ENTITY	Kindlin-2 Tyrosine Phosphorylation and Interaction with Src Serve as a Regulatable Switch in the Integrin_Outside-in Signaling Circuit .
22308309	0	Tyrosine	0,8	LAB	125,128	Tyrosine	LAB	CHEBI:18186	56743(Tax:10090)	Chemical	Gene	regulation|amod|START_ENTITY END_ENTITY|nsubj|regulation	Tyrosine phosphorylation-independent regulation of lipopolysaccharide-mediated response by the transmembrane adaptor protein LAB .
9618218	0	Tyrosine	4,12	LAR	0,3	Tyrosine	LAR	CHEBI:18186	104121(Tax:10090)	Chemical	Gene	Receptor|compound|START_ENTITY Receptor|compound|END_ENTITY	LAR Tyrosine Phosphatase Receptor : A Developmental Isoform Is Present in Neurites and Growth Cones and Its Expression Is Regional - and Cell-Specific .
9891970	0	Tyrosine	0,8	LAT	46,49	Tyrosine	LAT	CHEBI:18186	27040	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation and translocation of LAT in platelets .
25391905	0	Tyrosine	0,8	LRP6	28,32	Tyrosine	LRP6	CHEBI:18186	16974(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of LRP6 by Src and Fer inhibits Wnt/b-catenin signalling .
10318843	0	Tyrosine	0,8	Lck	95,98	Tyrosine	Lck	CHEBI:18186	3932	Chemical	Gene	319|compound|START_ENTITY site|nsubj|319 site|nmod|domain domain|nmod|END_ENTITY	Tyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of Lck .
26529315	0	Tyrosine	22,30	LepR	17,21	Tyrosine	LepR	D014443	16847(Tax:10090)	Chemical	Gene	Mutations|compound|START_ENTITY Mutations|compound|END_ENTITY	The Influence of LepR Tyrosine Site Mutations on Mouse Ovary Development and Related Gene Expression Changes .
26731115	0	Tyrosine	84,92	Lyn	80,83	Tyrosine	Lyn	D014443	4067	Chemical	Gene	Kinase|compound|START_ENTITY Kinase|compound|END_ENTITY	Directed Evolution of a Highly Specific FN3 Monobody to the SH3 Domain of Human Lyn Tyrosine Kinase .
7927516	0	Tyrosine	0,8	MB-1	28,32	Tyrosine	MB-1	CHEBI:18186	973	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of MB-1 , B29 , and HS1 proteins in human B cells following receptor crosslinking .
7988707	0	Tyrosine	0,8	MUC1	32,36	Tyrosine	MUC1	CHEBI:18186	4582	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of the MUC1 breast_cancer_membrane_proteins .
12110584	0	Tyrosine	0,8	Mdm2	28,32	Tyrosine	Mdm2	CHEBI:18186	4193	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of Mdm2 by c-Abl : implications for p53 regulation .
10751793	0	Tyrosine	0,8	Moesin	28,34	Tyrosine	Moesin	CHEBI:18186	4478	Chemical	Gene	Phosphorylation|compound|START_ENTITY Phosphorylation|nmod|END_ENTITY	Tyrosine Phosphorylation of Moesin in Arachidonic_Acid-Stimulated Human Platelets .
17916632	0	Tyrosine	0,8	Munc18c	28,35	Tyrosine	Munc18c	CHEBI:18186	6814	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of Munc18c regulates platelet-derived growth factor-stimulated glucose_transporter_4 translocation in 3T3L1 adipocytes .
21548926	0	Tyrosine	0,8	Munc18c	28,35	Tyrosine	Munc18c	CHEBI:18186	6814	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of Munc18c on residue 521 abrogates binding to Syntaxin_4 .
25292214	0	Tyrosine	0,8	NEDD4	28,33	Tyrosine	NEDD4	CHEBI:18186	4734	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of NEDD4 activates its ubiquitin ligase activity .
11231305	0	Tyrosine	0,8	NF-kappa_B	49,59	Tyrosine	NF-kappa B	CHEBI:18186	4790	Chemical	Gene	START_ENTITY|dobj|activation activation|nmod|END_ENTITY	Tyrosine phosphorylation-dependent activation of NF-kappa_B .
15050291	0	Tyrosine	0,8	NFkappaB	49,57	Tyrosine	NFkappaB	CHEBI:18186	4790	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Tyrosine phosphorylation-dependent activation of NFkappaB is compromised in T cells from the elderly .
15069547	0	Tyrosine	0,8	NOS3	28,32	Tyrosine	NOS3	CHEBI:18186	18127(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of NOS3 in a breast_cancer cell line and Src-transformed cells .
26802179	0	Tyrosine	8,16	Nephrin	0,7	Tyrosine	Nephrin	D014443	54631(Tax:10090)	Chemical	Gene	Phosphorylation|compound|START_ENTITY Phosphorylation|compound|END_ENTITY	Nephrin Tyrosine Phosphorylation Is Required to Stabilize and Restore Podocyte Foot Process Architecture .
26848974	0	Tyrosine	37,45	Nephrin	29,36	Tyrosine	Nephrin	D014443	4868	Chemical	Gene	Phosphorylation|compound|START_ENTITY Phosphorylation|compound|END_ENTITY	Integrin Ligation Results in Nephrin Tyrosine Phosphorylation In Vitro .
7514867	0	Tyrosine	0,8	P-selectin	28,38	Tyrosine	P-selectin	CHEBI:18186	6403	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of P-selectin in intact platelets and in a disulphide-linked complex with immunoprecipitated pp60c-src .
12869560	0	Tyrosine	0,8	P2X7_receptor	45,58	Tyrosine	P2X7 receptor	CHEBI:18186	5027	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|HSP90 HSP90|nmod|complex complex|amod|END_ENTITY	Tyrosine phosphorylation of HSP90 within the P2X7_receptor complex negatively regulates P2X7_receptors .
25125660	0	Tyrosine	5,13	PAK1	0,4	Tyrosine	PAK1	CHEBI:18186	18479(Tax:10090)	Chemical	Gene	Phosphorylation|compound|START_ENTITY Phosphorylation|compound|END_ENTITY	PAK1 Tyrosine Phosphorylation Is Required to Induce Epithelial-Mesenchymal_Transition and Radioresistance in Lung_Cancer Cells .
9084985	0	Tyrosine	0,8	PECAM-1	75,82	Tyrosine	PECAM-1	CHEBI:18186	282303(Tax:9913)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	Tyrosine phosphorylation of platelet_endothelial_cell_adhesion_molecule-1 -LRB- PECAM-1 , CD31 -RRB- in mechanically stimulated vascular endothelial cells .
7688221	0	Tyrosine	0,8	PLC-gamma_1	28,39	Tyrosine	PLC-gamma 1	CHEBI:18186	25738(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of PLC-gamma_1 induced by electroconvulsive_shock in rat hippocampus .
19360341	0	Tyrosine	0,8	PP2A	28,32	Tyrosine	PP2A	CHEBI:18186	5524	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of PP2A is regulated by HER-2 signalling and correlates with breast_cancer progression .
26694178	0	Tyrosine	16,24	Phosphatase_Receptor_J	25,47	Tyrosine	Phosphatase Receptor J	D014443	5795	Chemical	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Loss of Protein Tyrosine Phosphatase_Receptor_J Expression Predicts an Aggressive Clinical Course in Patients with Esophageal_Squamous_Cell_Carcinoma .
25289695	0	Tyrosine	18,26	Phospholipid_Scramblase_1	46,71	Tyrosine	Phospholipid Scramblase 1	CHEBI:18186	117540(Tax:10116)	Chemical	Gene	Phosphorylation|compound|START_ENTITY Phosphorylation|nmod|END_ENTITY	Regulation of the Tyrosine Phosphorylation of Phospholipid_Scramblase_1 in Mast Cells That Are Stimulated through the High-Affinity IgE Receptor .
26164717	0	Tyrosine	54,62	Pleiotrophin	14,26	Tyrosine	Pleiotrophin	D014443	5764	Chemical	Gene	Phosphatase|compound|START_ENTITY Phosphatase|compound|END_ENTITY	Regulation of Pleiotrophin , Midkine , Receptor Protein Tyrosine Phosphatase b / , and Their Intracellular Signaling Cascades in the Nucleus Accumbens During Opiate Administration .
26338327	0	Tyrosine	24,32	Pleiotrophin	64,76	Tyrosine	Pleiotrophin	D014443	19242(Tax:10090)	Chemical	Gene	Z|compound|START_ENTITY Z|nmod|Remyelination Remyelination|compound|END_ENTITY	Inactivation of Protein Tyrosine Phosphatase Receptor Type Z by Pleiotrophin Promotes Remyelination through Activation of Differentiation of Oligodendrocyte Precursor Cells .
24718602	0	Tyrosine	0,8	Pyk2	32,36	Tyrosine	Pyk2	CHEBI:18186	50646(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine 402 phosphorylation of Pyk2 is involved in ionomycin-induced neurotransmitter release .
9104812	0	Tyrosine	0,8	Pyk2	28,32	Tyrosine	Pyk2	CHEBI:18186	2185	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of Pyk2 is selectively regulated by Fyn during TCR signaling .
12682013	0	Tyrosine	0,8	QKI	28,31	Tyrosine	QKI	CHEBI:18186	9444	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of QKI mediates developmental signals to regulate mRNA metabolism .
24744988	0	Tyrosine	123,131	RET	177,180	Tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|nmod|Globally Globally|amod|RTK-Rearranged RTK-Rearranged|dep|ROS1 ROS1|dep|END_ENTITY	Will the Requirement by the US FDA to Simultaneously Co-Develop Companion Diagnostics -LRB- CDx -RRB- Delay the Approval of Receptor Tyrosine Kinase Inhibitors for RTK-Rearranged -LRB- ROS1 - , RET - , AXL - , PDGFR-a - , NTRK1 - -RRB- Non-Small_Cell_Lung_Cancer Globally ?
14982882	0	Tyrosine	0,8	RON	25,28	Tyrosine	RON	CHEBI:18186	4486	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|dobj|downstream downstream|compound|END_ENTITY	Tyrosine kinase receptor RON functions downstream of the erythropoietin receptor to induce expansion of erythroid progenitors .
21114864	0	Tyrosine	163,171	RON	150,153	Tyrosine	RON	CHEBI:18186	4486	Chemical	Gene	Kinase|compound|START_ENTITY Kinase|compound|END_ENTITY	Deletion or insertion in the first immunoglobulin-plexin-transcription -LRB- IPT -RRB- domain differentially regulates expression and tumorigenic activities of RON receptor Tyrosine Kinase .
21723047	0	Tyrosine	0,8	RON	25,28	Tyrosine	RON	CHEBI:18186	4486	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|dobj|END_ENTITY	Tyrosine kinase receptor RON and its ligand MSP in Merkel_cell_carcinoma .
25978653	0	Tyrosine	22,30	ROR1	38,42	Tyrosine	ROR1	D014443	4919	Chemical	Gene	Proliferation|compound|START_ENTITY Proliferation|compound|END_ENTITY	Silencing of Receptor Tyrosine Kinase ROR1 Inhibits Tumor-Cell Proliferation via PI3K/AKT/mTOR Signaling Pathway in Lung_Adenocarcinoma .
22163037	0	Tyrosine	0,8	Rac1	28,32	Tyrosine	Rac1	CHEBI:18186	5879	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of Rac1 : a role in regulation of cell spreading .
10373531	0	Tyrosine	0,8	Raf-1	50,55	Tyrosine	Raf-1	CHEBI:18186	5894	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of the proto-oncoprotein Raf-1 is regulated by Raf-1 itself and the phosphatase Cdc25A .
8954631	0	Tyrosine	48,56	Rapsyn	31,37	Tyrosine	Rapsyn	CHEBI:18186	5913	Chemical	Gene	Phosphorylation|compound|START_ENTITY Phosphorylation|compound|END_ENTITY	The Synapse-Associated Protein Rapsyn Regulates Tyrosine Phosphorylation of Proteins Colocalized at Nicotinic Acetylcholine Receptor Clusters Protein tyrosine phosphorylation has been suggested to play an important role in the clustering of the nicotinic acetylcholine receptor -LRB- AChR -RRB- at the developing neuromuscular junction .
20304029	0	Tyrosine	0,8	SHIP	28,32	Tyrosine	SHIP	CHEBI:18186	16331(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of SHIP promotes its proteasomal degradation .
9341117	0	Tyrosine	0,8	SHIP	43,47	Tyrosine	SHIP	CHEBI:18186	3635	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation and relocation of SHIP are integrin-mediated in thrombin-stimulated human blood platelets .
11740867	0	Tyrosine	0,8	SHP-1	22,27	Tyrosine	SHP-1	CHEBI:18186	15170(Tax:10090)	Chemical	Gene	phosphatases|amod|START_ENTITY phosphatases|amod|END_ENTITY	Tyrosine phosphatases SHP-1 and SHP-2 are associated with distinct tyrosine-phosphorylated proteins .
20077161	0	Tyrosine	0,8	SHP-1	21,26	Tyrosine	SHP-1	CHEBI:18186	5777	Chemical	Gene	phosphatase|nsubj|START_ENTITY phosphatase|dobj|END_ENTITY	Tyrosine phosphatase SHP-1 in allergic and anaphylactic inflammation .
26416283	0	Tyrosine	8,16	SHP-1	29,34	Tyrosine	SHP-1	D014443	15170(Tax:10090)	Chemical	Gene	Cell|compound|START_ENTITY Cell|compound|END_ENTITY	Protein Tyrosine Phosphatase SHP-1 Modulates T Cell Responses by Controlling Cbl-b Degradation .
9813145	0	Tyrosine	0,8	SHP-1	35,40	Tyrosine	SHP-1	CHEBI:18186	5777	Chemical	Gene	unphosphorylated|nsubj|START_ENTITY unphosphorylated|ccomp|substrate substrate|nsubj|END_ENTITY	Tyrosine unphosphorylated platelet SHP-1 is a substrate for calpain .
25824741	0	Tyrosine	59,67	SHP1	25,29	Tyrosine	SHP1	CHEBI:18186	8431	Chemical	Gene	Kinase|compound|START_ENTITY Mutation|nmod|Kinase Mutation|compound|END_ENTITY	Methylated Alteration of SHP1 Complements Mutation of JAK2 Tyrosine Kinase in Patients with Myeloproliferative_Neoplasm .
21145937	0	Tyrosine	0,8	SHP2	85,89	Tyrosine	SHP2	CHEBI:18186	5781	Chemical	Gene	phosphatases|amod|START_ENTITY phosphatases|dep|END_ENTITY	Tyrosine phosphatases as key regulators of StAR induction and cholesterol transport : SHP2 as a potential tyrosine phosphatase involved in steroid synthesis .
25876044	0	Tyrosine	4,12	SHP2	25,29	Tyrosine	SHP2	D014443	5781	Chemical	Gene	Associates|compound|START_ENTITY Associates|compound|END_ENTITY	The Tyrosine Phosphatase SHP2 Associates with CUB_Domain-Containing_Protein-1 -LRB- CDCP1 -RRB- , Regulating Its Expression at the Cell Surface in a Phosphorylation-Dependent Manner .
25876044	0	Tyrosine	4,12	SHP2	25,29	Tyrosine	SHP2	D014443	5781	Chemical	Gene	Associates|compound|START_ENTITY Associates|compound|END_ENTITY	The Tyrosine Phosphatase SHP2 Associates with CUB_Domain-Containing_Protein-1 -LRB- CDCP1 -RRB- , Regulating Its Expression at the Cell Surface in a Phosphorylation-Dependent Manner .
10026222	0	Tyrosine	0,8	SLP-76	28,34	Tyrosine	SLP-76	CHEBI:18186	3937	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of SLP-76 is downstream of Syk following stimulation of the collagen receptor in platelets .
26232434	0	Tyrosine	99,107	STAT1	127,132	Tyrosine	STAT1	D014443	6772	Chemical	Gene	Phosphorylation|compound|START_ENTITY Phosphorylation|nmod|END_ENTITY	Parafibromin Is a Component of IFN-y-Triggered Signaling Pathways That Facilitates JAK1/2-Mediated Tyrosine Phosphorylation of STAT1 .
26232434	0	Tyrosine	99,107	STAT1	127,132	Tyrosine	STAT1	D014443	6772	Chemical	Gene	Phosphorylation|compound|START_ENTITY Phosphorylation|nmod|END_ENTITY	Parafibromin Is a Component of IFN-y-Triggered Signaling Pathways That Facilitates JAK1/2-Mediated Tyrosine Phosphorylation of STAT1 .
10080923	0	Tyrosine	0,8	STAT3	28,33	Tyrosine	STAT3	CHEBI:18186	20848(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of STAT3 by leptin through leptin_receptor in mouse metaphase 2 stage oocyte .
15527783	0	Tyrosine	0,8	STAT3	30,35	Tyrosine	STAT3	CHEBI:18186	6774	Chemical	Gene	dephosphorylation|amod|START_ENTITY dephosphorylation|nmod|END_ENTITY	Tyrosine dephosphorylation of STAT3 in SARS_coronavirus-infected Vero E6 cells .
20388777	5	Tyrosine	773,781	STAT3	801,806	Tyrosine	STAT3	CHEBI:18186	6774	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of STAT3 was also dependent on concomitant FGFR-dependent activity of SRC and JAK kinases .
26380299	0	Tyrosine	0,8	STAT3	32,37	Tyrosine	STAT3	D014443	20848(Tax:10090)	Chemical	Gene	Phosphorylation|compound|START_ENTITY Phosphorylation|nmod|END_ENTITY	Tyrosine 705 Phosphorylation of STAT3 Is Associated with Phenotype Severity in TGFb1 Transgenic_Mice .
7568001	0	Tyrosine	0,8	STAT5	43,48	Tyrosine	STAT5	CHEBI:18186	6776	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation and activation of STAT5 , STAT3 , and Janus kinases by interleukins 2 and 15 .
26491948	0	Tyrosine	38,46	SYK	55,58	Tyrosine	SYK	D014443	6850	Chemical	Gene	Kinase|compound|START_ENTITY Kinase|appos|END_ENTITY	From CLL to Multiple_Myeloma - Spleen Tyrosine Kinase -LRB- SYK -RRB- influences multiple_myeloma cell survival and migration .
11290743	1	Tyrosine	62,70	Shc	57,60	Tyrosine	Shc	CHEBI:18186	20416(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	p46/52 -LRB- Shc -RRB- Tyrosine phosphorylation is required for CSF-1-mediated macrophage differentiation .
7513165	0	Tyrosine	0,8	Shc	28,31	Tyrosine	Shc	CHEBI:18186	20416(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of Shc is induced by IL-3 , IL-5 and GM-CSF .
7784091	0	Tyrosine	0,8	Shc	28,31	Tyrosine	Shc	CHEBI:18186	20416(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|proteins proteins|compound|END_ENTITY	Tyrosine phosphorylation of Shc proteins and formation of Shc/Grb2 complex correlate to the transformation of NIH3T3 cells mediated by the point-mutation activated neu .
7896829	0	Tyrosine	0,8	Shc	28,31	Tyrosine	Shc	CHEBI:18186	6464	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of Shc is mediated through Lyn and Syk in B cell receptor signaling .
8752899	0	Tyrosine	0,8	Shc	28,31	Tyrosine	Shc	CHEBI:18186	6464	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of Shc is not required for proliferation or viability signaling by granulocyte-macrophage_colony-stimulating_factor in hematopoietic cell lines .
15569927	0	Tyrosine	0,8	Shp2	60,64	Tyrosine	Shp2	CHEBI:18186	19247(Tax:10090)	Chemical	Gene	sites|amod|START_ENTITY sites|nmod|FRS2alpha FRS2alpha|amod|responsible responsible|nmod|recruitment recruitment|amod|END_ENTITY	Tyrosine phosphorylation sites on FRS2alpha responsible for Shp2 recruitment are critical for induction of lens and retina .
26979794	0	Tyrosine	16,24	Shp2	37,41	Tyrosine	Shp2	D014443	5781	Chemical	Gene	Interacts|compound|START_ENTITY Interacts|compound|END_ENTITY	Correction : The Tyrosine Phosphatase Shp2 Interacts with NPM-ALK and Regulates Anaplastic_Lymphoma Cell Growth and Migration .
12815057	0	Tyrosine	0,8	Sprouty2	28,36	Tyrosine	Sprouty2	CHEBI:18186	10253	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of Sprouty2 enhances its interaction with c-Cbl and is crucial for its function .
14691141	0	Tyrosine	0,8	Src	81,84	Tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of type Igamma phosphatidylinositol_phosphate kinase by Src regulates an integrin-talin switch .
25381250	0	Tyrosine	34,42	Src	30,33	Tyrosine	Src	CHEBI:18186	20779(Tax:10090)	Chemical	Gene	Activation|compound|START_ENTITY Activation|compound|END_ENTITY	Adaptor Protein GRB2 Promotes Src Tyrosine Kinase Activation and Podosomal Organization by Protein-tyrosine Phosphatase in Osteoclasts .
26260414	0	Tyrosine	126,134	Src	122,125	Tyrosine	Src	D014443	6714	Chemical	Gene	Kinase|compound|START_ENTITY Kinase|compound|END_ENTITY	Synthesis , Biological , and Computational Evaluation of Novel 1,3,5-Substituted _ Indolin-2-One Derivatives as Inhibitors of Src Tyrosine Kinase .
26466383	0	Tyrosine	4,12	Src	0,3	Tyrosine	Src	D014443	83805(Tax:10116)	Chemical	Gene	Activation|compound|START_ENTITY Activation|compound|END_ENTITY	Src Tyrosine Kinase Activation by 4-Hydroxynonenal Upregulates p38 , ERK/AP -1 Signaling and COX-2 Expression in YPEN-1 Cells .
26941850	0	Tyrosine	50,58	Src	46,49	Tyrosine	Src	D014443	20779(Tax:10090)	Chemical	Gene	Activity|compound|START_ENTITY Activity|compound|END_ENTITY	Novel Bioluminescent Activatable Reporter for Src Tyrosine Kinase Activity in Living Mice .
10704823	0	Tyrosine	0,8	Syk	63,66	Tyrosine	Syk	CHEBI:18186	6850	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	Tyrosine phosphorylation and association of FcgammaRII and p72 -LRB- Syk -RRB- are not limited to the FcgammaRII signalling pathway .
25862820	0	Tyrosine	4,12	Syk	0,3	Tyrosine	Syk	D014443	427272(Tax:9031)	Chemical	Gene	Kinase|compound|START_ENTITY Kinase|compound|END_ENTITY	Syk Tyrosine Kinase Is Critical for B Cell Antibody Responses and Memory B Cell Survival .
7530449	0	Tyrosine	0,8	Syk	44,47	Tyrosine	Syk	CHEBI:18186	6850	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation and association of Syk with Fc_gamma_RII in monocytic THP-1 cells .
8163536	10	Tyrosine	1127,1135	Syk	1155,1158	Tyrosine	SYK	CHEBI:18186	6850	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of Syk associating with the B cell receptor complex in human was augmented rapidly after surface immunoglobulin cross-linking .
8639815	0	Tyrosine	0,8	Syp	64,67	Tyrosine	Syp	CHEBI:18186	20977(Tax:10090)	Chemical	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Tyrosine 425 within the activated erythropoietin receptor binds Syp , reduces the erythropoietin required for Syp tyrosine phosphorylation , and promotes mitogenesis .
9742951	0	Tyrosine	0,8	TATA_element_modulatory_factor	32,62	Tyrosine	TATA element modulatory factor	CHEBI:18186	232286(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of the TATA_element_modulatory_factor by the FER nuclear tyrosine kinases .
9083267	0	Tyrosine	0,8	TGF-beta	40,48	Tyrosine	TGF-beta	CHEBI:18186	59086(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Tyrosine kinase dependent expression of TGF-beta induced by stretch in mesangial cells .
22479513	0	Tyrosine	0,8	TRIM21	52,58	Tyrosine	TRIM21	CHEBI:18186	6737	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of the E3 ubiquitin ligase TRIM21 positively regulates interaction with IRF3 and hence TRIM21 activity .
21471003	0	Tyrosine	0,8	TRPC6	49,54	Tyrosine	TRPC6	CHEBI:18186	7225	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Tyrosine phosphorylation-dependent activation of TRPC6 regulated by PLC-y1 and nephrin : effect of mutations associated with focal_segmental_glomerulosclerosis .
15972471	0	Tyrosine	0,8	Tarp	60,64	Tyrosine	Tarp	CHEBI:18186	445347	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of the chlamydial effector protein Tarp is species specific and not required for recruitment of actin .
20973951	0	Tyrosine	0,8	Tie2	37,41	Tyrosine	Tie2	CHEBI:18186	7010	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of Grb14 by Tie2 .
23230270	0	Tyrosine	0,8	Trio	71,75	Tyrosine	Trio	CHEBI:18186	310192(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of the Rho guanine_nucleotide exchange factor Trio regulates netrin-1 / DCC-mediated cortical axon outgrowth .
8384556	0	Tyrosine	0,8	Trk	39,42	Tyrosine	Trk	CHEBI:18186	4914	Chemical	Gene	785|compound|START_ENTITY determinant|nsubj|785 determinant|nmod|END_ENTITY	Tyrosine 785 is a major determinant of Trk -- substrate interaction .
25954527	0	Tyrosine	57,65	TrkA	43,47	Tyrosine	TrkA	D014443	4914	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|compound|END_ENTITY	Identification of a Novel Series of Potent TrkA Receptor Tyrosine Kinase Inhibitors .
17873329	0	Tyrosine	0,8	TrkB	28,32	Tyrosine	TrkB	CHEBI:18186	4915	Chemical	Gene	receptor|amod|START_ENTITY kinase|nsubj|receptor kinase|xcomp|expression expression|nsubj|B B|appos|END_ENTITY	Tyrosine receptor kinase B -LRB- TrkB -RRB- protein expression in the human endometrium .
7989749	0	Tyrosine	0,8	VCP	28,31	Tyrosine	VCP	CHEBI:18186	7415	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of VCP , the mammalian homologue of the Saccharomyces_cerevisiae CDC48 protein , is unusually sensitive to stimulation by sodium_vanadate and hydrogen_peroxide .
16027153	0	Tyrosine	0,8	VE-cadherin	28,39	Tyrosine	VE-cadherin	CHEBI:18186	1003	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of VE-cadherin prevents binding of p120 - and beta-catenin and maintains the cellular mesenchymal state .
21168935	0	Tyrosine	0,8	VE-cadherin	28,39	Tyrosine	VE-cadherin	CHEBI:18186	1003	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of VE-cadherin and claudin-5 is associated with TGF-b1-induced permeability of centrally derived vascular endothelium .
25471178	0	Tyrosine	0,8	VEGFR	93,98	Tyrosine	VEGFR	CHEBI:18186	3791	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Tyrosine kinase inhibitors directed against the vascular_endothelial_growth_factor_receptor -LRB- VEGFR -RRB- have distinct cutaneous toxicity profiles : a meta-analysis and review of the literature .
10816419	0	Tyrosine	0,8	VEGFR-2	79,86	Tyrosine	VEGFR-2	CHEBI:18186	3791	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of the vascular_endothelial-growth-factor_receptor-2 -LRB- VEGFR-2 -RRB- is modulated by Rho proteins .
26860998	0	Tyrosine	62,70	VEGFR-2	54,61	Tyrosine	VEGFR-2	D014443	3791	Chemical	Gene	Inhibitors|compound|START_ENTITY Inhibitors|compound|END_ENTITY	Anti-Angiogenic Therapy : Strategies to Develop Potent VEGFR-2 Tyrosine Kinase Inhibitors and Future Prospect .
24589997	0	Tyrosine	35,43	VEGFR-3	27,34	Tyrosine	VEGFR-3	CHEBI:18186	14257(Tax:10090)	Chemical	Gene	Kinase|compound|START_ENTITY Kinase|compound|END_ENTITY	Specific Inhibition of the VEGFR-3 Tyrosine Kinase by SAR131675 Reduces Peripheral and Tumor Associated Immunosuppressive Myeloid Cells .
12447358	0	Tyrosine	0,8	VHR	28,31	Tyrosine	VHR	CHEBI:18186	1845	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of VHR phosphatase by ZAP-70 .
10395673	0	Tyrosine	0,8	Vav	28,31	Tyrosine	Vav	CHEBI:18186	25156(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of Vav stimulates IL-6 production in mast cells by a Rac/c-Jun N-terminal kinase-dependent pathway .
7539782	0	Tyrosine	0,8	Vav	55,58	Tyrosine	Vav	CHEBI:18186	7409	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of the proto-oncogene product Vav and its association with the adapter Grb2/Ash in a human leukemia cell line UT-7 .
8133029	0	Tyrosine	0,8	Vav	43,46	Tyrosine	Vav	CHEBI:18186	7409	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation and activation of Vav GTP/GDP exchange activity in antigen receptor-triggered B cells .
22133775	0	Tyrosine	0,8	WASP	28,32	Tyrosine	WASP	CHEBI:18186	7454	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of WASP promotes calpain-mediated_podosome_disassembly .
25413351	0	Tyrosine	0,8	WIP	28,31	Tyrosine	WIP	CHEBI:18186	7456	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of WIP releases bound WASP and impairs podosome assembly in macrophages .
21642474	0	Tyrosine	0,8	WW-domain_binding_protein_2	56,83	Tyrosine	WW-domain binding protein 2	CHEBI:18186	23558	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of transcriptional coactivator WW-domain_binding_protein_2 regulates estrogen_receptor_a function in breast_cancer via the Wnt pathway .
8906806	0	Tyrosine	0,8	ZAP-70	44,50	Tyrosine	ZAP-70	CHEBI:18186	7535	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation and recruitment of ZAP-70 to the CD3-TCR complex are defective after CD2 stimulation .
15342355	0	Tyrosine	0,8	a_kinase_anchoring_protein_3	32,60	Tyrosine	a kinase anchoring protein 3	CHEBI:18186	10566	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of the a_kinase_anchoring_protein_3 -LRB- AKAP3 -RRB- and soluble adenylate cyclase are involved in the increase of human sperm motility by bicarbonate .
10601257	0	Tyrosine	0,8	alpha-actinin	28,41	Tyrosine	alpha-actinin	CHEBI:18186	87	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of alpha-actinin in activated platelets .
11821392	4	Tyrosine	776,784	alpha-synuclein	804,819	Tyrosine	alpha-synuclein	CHEBI:18186	6622	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of alpha-synuclein appears to play a modulatory role in the inhibition of PLD , because mutation of Tyr -LRB- 125 -RRB- _ to_Phe slightly increases inhibitory effect of alpha-synuclein on PLD activity .
19855133	0	Tyrosine	0,8	alpha-synuclein	39,54	Tyrosine	alpha-synuclein	CHEBI:18186	6622	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation .
11230336	0	Tyrosine	0,8	angiotensin_II	73,87	Tyrosine	angiotensin II	CHEBI:18186	24179(Tax:10116)	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|nmod|END_ENTITY	Tyrosine kinase involvement in renal arteriolar constrictor responses to angiotensin_II .
18565825	0	Tyrosine	0,8	annexin_A2	28,38	Tyrosine	annexin A2	CHEBI:18186	302	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of annexin_A2 regulates Rho-mediated actin rearrangement and cell adhesion .
24759800	0	Tyrosine	0,8	b-catenin	28,37	Tyrosine	b-catenin	CHEBI:18186	1499	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of b-catenin affects its subcellular localization and transcriptional activity of b-catenin in Hela and Bcap-37 cells .
11710913	0	Tyrosine	0,8	beta-catenin	47,59	Tyrosine	beta-catenin	CHEBI:18186	1499	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of human keratinocyte beta-catenin and plakoglobin reversibly regulates their binding to E-cadherin and alpha-catenin .
8081883	0	Tyrosine	0,8	beta-catenin	28,40	Tyrosine	beta-catenin	CHEBI:18186	1499	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of beta-catenin and plakoglobin enhanced by hepatocyte growth factor and epidermal_growth_factor in human carcinoma cells .
26235616	0	Tyrosine	15,23	c-Abl	0,5	Tyrosine	c-Abl	D014443	25	Chemical	Gene	Phosphorylation|compound|START_ENTITY Phosphorylation|amod|END_ENTITY	c-Abl Mediated Tyrosine Phosphorylation of Aha1 Activates Its Co-chaperone Function in Cancer Cells .
9705354	0	Tyrosine	0,8	c-ErbB-2	28,36	Tyrosine	c-ErbB-2	CHEBI:18186	2064	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of c-ErbB-2 is regulated by the cellular form of prostatic_acid phosphatase in human_prostate_cancer cells .
23637779	0	Tyrosine	0,8	c-Kit	53,58	Tyrosine	c-Kit	CHEBI:18186	3815	Chemical	Gene	kinase|amod|START_ENTITY inhibitors|nsubj|kinase inhibitors|xcomp|induce induce|dobj|down-regulation down-regulation|nmod|END_ENTITY	Tyrosine kinase inhibitors induce down-regulation of c-Kit by targeting the ATP pocket .
22798672	0	Tyrosine	0,8	c-Maf	28,33	Tyrosine	c-Maf	CHEBI:18186	4094	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of c-Maf enhances the expression of IL-4 gene .
25745036	0	Tyrosine	10,18	c-Met	4,9	Tyrosine	c-Met	D014443	100126565(Tax:9986)	Chemical	Gene	JNJ-38877605|compound|START_ENTITY JNJ-38877605|amod|END_ENTITY	The c-Met Tyrosine Kinase Inhibitor JNJ-38877605 Causes Renal_Toxicity through Species-Specific Insoluble Metabolite Formation .
7657591	0	Tyrosine	0,8	c-cbl	32,37	Tyrosine	c-cbl	CHEBI:18186	867	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|product product|amod|END_ENTITY	Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal_growth_factor _ -LRB- EGF -RRB- _ receptor upon EGF stimulation .
7782294	0	Tyrosine	0,8	c-cbl	50,55	Tyrosine	c-cbl	CHEBI:18186	12402(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|protein protein|amod|END_ENTITY	Tyrosine phosphorylation and translocation of the c-cbl protein after activation of tyrosine kinase signaling pathways .
8576149	0	Tyrosine	0,8	c-cbl	32,37	Tyrosine	c-cbl	CHEBI:18186	867	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|product product|amod|END_ENTITY	Tyrosine phosphorylation of the c-cbl proto-oncogene product mediated by cell surface antigen CD38 in HL-60 cells .
7509796	0	Tyrosine	0,8	c-kit	28,33	Tyrosine	c-kit	CHEBI:18186	3815	Chemical	Gene	719|amod|START_ENTITY 719|nmod|receptor receptor|amod|END_ENTITY	Tyrosine residue 719 of the c-kit receptor is essential for binding of the P85 subunit of phosphatidylinositol -LRB- PI -RRB- 3-kinase and for c-kit-associated PI 3-kinase activity in COS-1 cells .
2541345	0	Tyrosine	0,8	c-met	52,57	Tyrosine	c-met	CHEBI:18186	4233	Chemical	Gene	START_ENTITY|xcomp|indistinguishable indistinguishable|nmod|protein protein|amod|END_ENTITY	Tyrosine kinase receptor indistinguishable from the c-met protein .
15504032	0	Tyrosine	0,8	caveolin-2	28,38	Tyrosine	caveolin-2	CHEBI:18186	858	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of caveolin-2 at residue 27 : differences in the spatial and temporal behavior of phospho-Cav-2 -LRB- pY19 and pY27 -RRB- .
15958730	0	Tyrosine	0,8	caveolin_1	28,38	Tyrosine	caveolin 1	CHEBI:18186	857	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of caveolin_1 by oxidative stress is reversible and dependent on the c-src_tyrosine_kinase but not mitogen-activated protein kinase pathways in placental artery endothelial cells .
9278444	0	Tyrosine	0,8	connexin_43	28,39	Tyrosine	connexin 43	CHEBI:18186	14609(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of connexin_43 by v-Src is mediated by SH2 and SH3 domain interactions .
10438543	0	Tyrosine	0,8	cortactin	28,37	Tyrosine	cortactin	CHEBI:18186	2017	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of cortactin associated with Syk accompanies thromboxane analogue-induced platelet shape change .
10952984	0	Tyrosine	0,8	cortactin	28,37	Tyrosine	cortactin	CHEBI:18186	2017	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of cortactin is required for H2O2-mediated injury of human endothelial cells .
22078467	0	Tyrosine	0,8	cortactin	28,37	Tyrosine	cortactin	CHEBI:18186	13043(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of cortactin by the FAK-Src complex at focal adhesions regulates cell motility .
11171320	0	Tyrosine	0,8	ctn	33,36	Tyrosine	ctn	CHEBI:18186	12310(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of p120 -LRB- ctn -RRB- in v-Src transfected L cells depends on its association with E-cadherin and reduces adhesion activity .
25835355	0	Tyrosine	0,8	cytochrome_c	28,40	Tyrosine	cytochrome c	CHEBI:18186	54205	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of cytochrome_c as a signaling event in frozen thawed buffalo spermatozoa at the cross-roads of capacitation and apoptosis .
9622485	0	Tyrosine	0,8	dehydrogenase	78,91	Tyrosine	dehydrogenase	CHEBI:18186	2781506(Tax:882)	Chemical	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	Tyrosine 64 of cytochrome c553 is required for electron exchange with formate dehydrogenase in Desulfovibrio_vulgaris_Hildenborough .
16186108	0	Tyrosine	0,8	discoidin_domain_receptor_2	32,59	Tyrosine	discoidin domain receptor 2	CHEBI:18186	4921	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine 740 phosphorylation of discoidin_domain_receptor_2 by Src stimulates intramolecular autophosphorylation and Shc signaling complex formation .
17942722	0	Tyrosine	0,8	ephrinB2	34,42	Tyrosine	ephrinB2	CHEBI:18186	13642(Tax:10090)	Chemical	Gene	sites|amod|START_ENTITY sites|nmod|END_ENTITY	Tyrosine phosphorylation sites in ephrinB2 are required for hippocampal long-term potentiation but not long-term depression .
11687594	0	Tyrosine	0,8	epidermal_growth_factor_receptor	40,72	Tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	mapping|amod|START_ENTITY mapping|nmod|END_ENTITY	Tyrosine phosphorylation mapping of the epidermal_growth_factor_receptor signaling pathway .
15072863	0	Tyrosine	0,8	epidermal_growth_factor_receptor	34,66	Tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|dobj|inhibitors inhibitors|nmod|END_ENTITY	Tyrosine kinase inhibitors of the epidermal_growth_factor_receptor as adjuncts to systemic chemotherapy for muscle-invasive bladder_cancer .
1594497	0	Tyrosine	0,8	epidermal_growth_factor_receptor	28,60	Tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|dobj|activity activity|nmod|END_ENTITY	Tyrosine kinase activity of epidermal_growth_factor_receptor in human gastric_carcinomas .
1689310	0	Tyrosine	0,8	epidermal_growth_factor_receptor	72,104	Tyrosine	epidermal growth factor receptor	CHEBI:18186	407217(Tax:9913)	Chemical	Gene	residues|amod|START_ENTITY phosphorylated|nsubj|residues phosphorylated|nmod|END_ENTITY	Tyrosine residues in bovine phospholipase C-gamma phosphorylated by the epidermal_growth_factor_receptor in vitro .
19254954	0	Tyrosine	0,8	epidermal_growth_factor_receptor	70,102	Tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of the human glutathione_S-transferase_P1 by epidermal_growth_factor_receptor .
2153914	0	Tyrosine	0,8	epidermal_growth_factor_receptor	92,124	Tyrosine	epidermal growth factor receptor	CHEBI:18186	13649(Tax:10090)	Chemical	Gene	activity|amod|START_ENTITY essential|nsubj|activity essential|nmod|association association|nmod|C-gamma C-gamma|nmod|END_ENTITY	Tyrosine kinase activity is essential for the association of phospholipase C-gamma with the epidermal_growth_factor_receptor .
24004111	0	Tyrosine	0,8	epidermal_growth_factor_receptor	63,95	Tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	phosphorylation|amod|START_ENTITY reduces|nsubj|phosphorylation reduces|dobj|inhibition inhibition|nmod|END_ENTITY	Tyrosine phosphorylation of mig6 reduces its inhibition of the epidermal_growth_factor_receptor .
25855240	0	Tyrosine	0,8	epidermal_growth_factor_receptor	31,63	Tyrosine	epidermal growth factor receptor	D014443	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|non-small_cell_lung_cancers non-small_cell_lung_cancers|compound|END_ENTITY	Tyrosine kinase inhibitors for epidermal_growth_factor_receptor gene mutation-positive non-small_cell_lung_cancers : an update for recent advances in therapeutics .
26079946	0	Tyrosine	0,8	epidermal_growth_factor_receptor	71,103	Tyrosine	epidermal growth factor receptor	D014443	1956	Chemical	Gene	dephosphorylation|amod|START_ENTITY enhances|nsubj|dephosphorylation enhances|dobj|activity activity|nmod|END_ENTITY	Tyrosine dephosphorylation enhances the therapeutic target activity of epidermal_growth_factor_receptor -LRB- EGFR -RRB- by disrupting its interaction with estrogen_receptor -LRB- ER -RRB- .
2732223	0	Tyrosine	0,8	epidermal_growth_factor_receptor	63,95	Tyrosine	epidermal growth factor receptor	CHEBI:18186	407217(Tax:9913)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|acl|vitro vitro|nmod|END_ENTITY	Tyrosine phosphorylation of phospholipase_C-II in vitro by the epidermal_growth_factor_receptor .
8408058	0	Tyrosine	0,8	epidermal_growth_factor_receptor	96,128	Tyrosine	epidermal growth factor receptor	CHEBI:18186	13649(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY require|nsubj|phosphorylation require|nmod|END_ENTITY	Tyrosine phosphorylation of ras GTPase-activating protein does not require association with the epidermal_growth_factor_receptor .
8940106	0	Tyrosine	0,8	epidermal_growth_factor_receptor	127,159	Tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|pathway pathway|nmod|cells cells|nmod|END_ENTITY	Tyrosine phosphorylation of GSalpha and inhibition of bradykinin-induced activation of the cyclic_AMP pathway in A431 cells by epidermal_growth_factor_receptor .
10762642	0	Tyrosine	0,8	erbB-2	31,37	Tyrosine	erbB-2	CHEBI:18186	2064	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|protein protein|amod|END_ENTITY	Tyrosine phosphorylation of an erbB-2 related p90 protein induced by estrogen in human breast epithelial cells .
26620897	0	Tyrosine	47,55	erbB2	41,46	Tyrosine	erbB2	D014443	24337(Tax:10116)	Chemical	Gene	Kinase|compound|START_ENTITY Kinase|compound|END_ENTITY	Increased Expression of Neuregulin_1 and erbB2 Tyrosine Kinase in the Bladder of Rats With Cyclophosphamide-Induced Interstitial_Cystitis .
8639815	0	Tyrosine	0,8	erythropoietin	34,48	Tyrosine	erythropoietin	CHEBI:18186	13856(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	Tyrosine 425 within the activated erythropoietin receptor binds Syp , reduces the erythropoietin required for Syp tyrosine phosphorylation , and promotes mitogenesis .
10080960	0	Tyrosine	0,8	erythropoietin_receptor	25,48	Tyrosine	erythropoietin receptor	CHEBI:18186	2057	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Tyrosine residues of the erythropoietin_receptor are dispensable for erythroid differentiation of human CD34 + progenitors .
10967558	0	Tyrosine	0,8	ezrin	56,61	Tyrosine	ezrin	CHEBI:18186	484056(Tax:9615)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation and cellular redistribution of ezrin in MDCK cells treated with pervanadate .
10613738	0	Tyrosine	0,8	focal_adhesion_kinase	28,49	Tyrosine	focal adhesion kinase	CHEBI:18186	5747	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of focal_adhesion_kinase by PDGF is dependent on ras in human hepatic stellate cells .
10656875	0	Tyrosine	0,8	focal_adhesion_kinase	28,49	Tyrosine	focal adhesion kinase	CHEBI:18186	5747	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of focal_adhesion_kinase and paxillin regulates the signaling mechanism of the rapid nongenomic action of dexamethasone on actin cytoskeleton .
7529876	0	Tyrosine	0,8	focal_adhesion_kinase	28,49	Tyrosine	focal adhesion kinase	CHEBI:18186	5747	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of focal_adhesion_kinase at sites in the catalytic domain regulates kinase activity : a role for Src family kinases .
9748249	0	Tyrosine	0,8	focal_adhesion_kinase	28,49	Tyrosine	focal adhesion kinase	CHEBI:18186	14083(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of focal_adhesion_kinase stimulated by hepatocyte_growth_factor leads to mitogen-activated protein kinase activation .
19254954	0	Tyrosine	0,8	glutathione_S-transferase_P1	38,66	Tyrosine	glutathione S-transferase P1	CHEBI:18186	2950	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of the human glutathione_S-transferase_P1 by epidermal_growth_factor_receptor .
19473962	0	Tyrosine	0,8	growth_factor_receptor-bound_protein-7	28,66	Tyrosine	growth factor receptor-bound protein-7	CHEBI:18186	14786(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of growth_factor_receptor-bound_protein-7 by focal_adhesion_kinase in the regulation of cell migration , proliferation , and tumorigenesis .
8245472	0	Tyrosine	0,8	homodimer	42,51	Tyrosine	homodimer	CHEBI:18186	6647	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of a gamma-chain homodimer associated with Fc_gamma_RIII -LRB- CD16 -RRB- in cultured human monocytes .
1619013	0	Tyrosine	0,8	insulin	51,58	Tyrosine	insulin	CHEBI:18186	3630	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|nmod|infusion infusion|compound|END_ENTITY	Tyrosine kinase activity of skeletal muscle during insulin infusion in humans .
1910046	0	Tyrosine	0,8	insulin	26,33	Tyrosine	insulin	CHEBI:18186	3630	Chemical	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	Tyrosine kinase-defective insulin receptors undergo insulin-induced microaggregation but do not concentrate in coated_pits .
26082668	0	Tyrosine	0,8	insulin	36,43	Tyrosine	insulin	D014443	3630	Chemical	Gene	levels|amod|START_ENTITY associated|nsubjpass|levels associated|nmod|resistance resistance|compound|END_ENTITY	Tyrosine levels are associated with insulin resistance in patients with nonalcoholic_fatty_liver_disease .
26193769	0	Tyrosine	0,8	insulin	82,89	Tyrosine	insulin	D014443	3630	Chemical	Gene	nanoparticles|amod|START_ENTITY inhibit|nsubj|nanoparticles inhibit|dobj|amyloid_aggregation amyloid_aggregation|nmod|END_ENTITY	Tyrosine - and tryptophan-coated gold nanoparticles inhibit amyloid_aggregation of insulin .
26193769	0	Tyrosine	0,8	insulin	82,89	Tyrosine	insulin	D014443	3630	Chemical	Gene	nanoparticles|amod|START_ENTITY inhibit|nsubj|nanoparticles inhibit|dobj|amyloid_aggregation amyloid_aggregation|nmod|END_ENTITY	Tyrosine - and tryptophan-coated gold nanoparticles inhibit amyloid_aggregation of insulin .
6333431	0	Tyrosine	0,8	insulin	32,39	Tyrosine	insulin	CHEBI:18186	3630	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|receptor receptor|compound|END_ENTITY	Tyrosine kinase activity of the insulin receptor of patients with type_A extreme insulin resistance : studies with circulating mononuclear cells and cultured lymphocytes .
6333431	0	Tyrosine	0,8	insulin	81,88	Tyrosine	insulin	CHEBI:18186	3630	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|receptor receptor|nmod|patients patients|nmod|resistance resistance|compound|END_ENTITY	Tyrosine kinase activity of the insulin receptor of patients with type_A extreme insulin resistance : studies with circulating mononuclear cells and cultured lymphocytes .
9202243	0	Tyrosine	0,8	insulin-like_growth_factor-I_receptor	50,87	Tyrosine	insulin-like growth factor-I receptor	CHEBI:18186	16001(Tax:10090)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|domain domain|nmod|mediate mediate|amod|END_ENTITY	Tyrosine residues in the C-terminal domain of the insulin-like_growth_factor-I_receptor mediate mitogenic and tumorigenic signals .
8425625	0	Tyrosine	0,8	insulin-like_growth_factor_I	28,56	Tyrosine	insulin-like growth factor I	CHEBI:18186	3479	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Tyrosine kinase activity of insulin-like_growth_factor_I and insulin_receptors in human endometrium during the menstrual cycle : cyclic variation of insulin_receptor expression .
18679708	0	Tyrosine	0,8	insulin_receptor	28,44	Tyrosine	insulin receptor	CHEBI:18186	24954(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of insulin_receptor substrates during ischemia/reperfusion-induced apoptosis in rat liver .
2470095	0	Tyrosine	0,8	insulin_receptor	32,48	Tyrosine	insulin receptor	CHEBI:18186	24954(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of the insulin_receptor is not required for receptor internalization : studies in 2,4-dinitrophenol-treated cells .
2690816	0	Tyrosine	0,8	insulin_receptor	34,50	Tyrosine	insulin receptor	CHEBI:18186	24954(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Tyrosine kinase activity of liver insulin_receptor is inhibited in rats at term gestation .
7629118	0	Tyrosine	0,8	insulin_receptor_substrate-1	28,56	Tyrosine	insulin receptor substrate-1	CHEBI:18186	3667	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of insulin_receptor_substrate-1 in vivo depends upon the presence of its pleckstrin homology region .
20702409	0	Tyrosine	0,8	integrin_beta3	28,42	Tyrosine	integrin beta3	CHEBI:18186	3690	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of integrin_beta3 regulates kindlin-2 binding and integrin activation .
21969607	0	Tyrosine	0,8	lactate_dehydrogenase_A	28,51	Tyrosine	lactate dehydrogenase A	CHEBI:18186	3939	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of lactate_dehydrogenase_A is important for NADH/NAD -LRB- + -RRB- redox homeostasis in cancer cells .
1906156	0	Tyrosine	0,8	lck	104,107	Tyrosine	lck	CHEBI:18186	3932	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|acl|expressing expressing|dobj|END_ENTITY	Tyrosine phosphorylation of GAP and GAP-associated proteins in lymphoid and fibroblast cells expressing lck .
21269457	0	Tyrosine	0,8	lck	58,61	Tyrosine	lck	CHEBI:18186	3932	Chemical	Gene	phosphorylation|amod|START_ENTITY kinases|nsubj|phosphorylation kinases|dobj|END_ENTITY	Tyrosine phosphorylation of tau by the SRC family kinases lck and fyn .
12127964	0	Tyrosine	0,8	maspin	28,34	Tyrosine	maspin	CHEBI:18186	20724(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of maspin in normal mammary epithelia and breast_cancer cells .
1328534	0	Tyrosine	0,8	microtubule-associated_protein	28,58	Tyrosine	microtubule-associated protein	CHEBI:18186	51115	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of microtubule-associated_protein kinase after transient ischemia in the gerbil brain .
24004111	0	Tyrosine	0,8	mig6	28,32	Tyrosine	mig6	CHEBI:18186	54206	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of mig6 reduces its inhibition of the epidermal_growth_factor_receptor .
12515325	0	Tyrosine	0,8	nerve_growth_factor	28,47	Tyrosine	nerve growth factor	CHEBI:18186	310738(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Tyrosine kinase activity of nerve_growth_factor and estrogen in embryonic septal neurons cultured from the rat .
11013243	0	Tyrosine	0,8	neuromedin_B_receptor	52,73	Tyrosine	neuromedin B receptor	CHEBI:18186	4829	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Tyrosine 220 in the 5th transmembrane domain of the neuromedin_B_receptor is critical for the high selectivity of the peptoid antagonist PD168368 .
9580637	0	Tyrosine	0,8	nuclear_factor-kappa_B	72,94	Tyrosine	nuclear factor-kappa B	CHEBI:18186	4790	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Tyrosine phosphatase-dependent/tyrosine kinase-independent induction of nuclear_factor-kappa_B by tumor_necrosis_factor-alpha : effects on prostaglandin_endoperoxide_synthase-2 mRNA accumulation .
12604349	0	Tyrosine	0,8	occludin	28,36	Tyrosine	occludin	CHEBI:18186	100506658	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of occludin attenuates its interactions with ZO-1 , ZO-2 , and ZO-3 .
11707267	0	Tyrosine	0,8	p110	50,54	Tyrosine	p110	CHEBI:18186	9733	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of the catalytic subunit p110 of phosphatidylinositol-3 kinase induced by HMG-CoA reductase inhibitor inhibits its kinase activity in L6 myoblasts .
10737896	0	Tyrosine	0,8	p125	28,32	Tyrosine	p125	CHEBI:18186	207352(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of p125 -LRB- Fak -RRB- , p130 -LRB- Cas -RRB- , and paxillin does not require extracellular signal-regulated kinase activation in Swiss_3T3 cells stimulated by bombesin or platelet-derived growth factor .
9083073	0	Tyrosine	0,8	p130	28,32	Tyrosine	p130	CHEBI:18186	70769(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of p130 -LRB- cas -RRB- by bombesin , lysophosphatidic_acid , phorbol_esters , and platelet-derived growth factor .
10801330	0	Tyrosine	0,8	p130Cas	156,163	Tyrosine	p130Cas	CHEBI:18186	9564	Chemical	Gene	dephosphorylation|amod|START_ENTITY dependent|nsubj|dephosphorylation dependent|nmod|platelets platelets|dep|implication implication|nmod|involvement involvement|amod|END_ENTITY	Tyrosine dephosphorylation , but not phosphorylation , of p130Cas is dependent on integrin alpha IIb beta 3-mediated aggregation in platelets : implication of p130Cas involvement in pathways unrelated to cytoskeletal reorganization .
10801330	0	Tyrosine	0,8	p130Cas	56,63	Tyrosine	p130Cas	CHEBI:18186	9564	Chemical	Gene	dephosphorylation|amod|START_ENTITY dephosphorylation|nmod|END_ENTITY	Tyrosine dephosphorylation , but not phosphorylation , of p130Cas is dependent on integrin alpha IIb beta 3-mediated aggregation in platelets : implication of p130Cas involvement in pathways unrelated to cytoskeletal reorganization .
23874939	0	Tyrosine	0,8	p130Cas	94,101	Tyrosine	p130Cas	CHEBI:18186	9564	Chemical	Gene	Y189|compound|START_ENTITY conserved|nsubjpass|Y189 conserved|nmod|Y253 Y253|amod|END_ENTITY	Tyrosine Y189 in the substrate domain of the adhesion docking protein NEDD9 is conserved with p130Cas Y253 and regulates NEDD9-mediated migration and focal adhesion dynamics .
7545676	0	Tyrosine	0,8	p130Cas	28,35	Tyrosine	p130Cas	CHEBI:18186	12927(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of p130Cas and cortactin accompanies integrin-mediated cell adhesion to extracellular matrix .
9183645	0	Tyrosine	0,8	p130Cas	28,35	Tyrosine	p130Cas	CHEBI:18186	9564	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of p130Cas in cell adhesion and transformation .
9556601	0	Tyrosine	0,8	p130Cas	28,35	Tyrosine	p130Cas	CHEBI:18186	12927(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of p130Cas is involved in actin organization in osteoclasts .
9575907	0	Tyrosine	0,8	p130Cas	44,51	Tyrosine	p130Cas	CHEBI:18186	9564	Chemical	Gene	START_ENTITY|dobj|phosphorylation phosphorylation|nmod|II II|amod|END_ENTITY	Tyrosine phosphorylation and association of p130Cas and c-Crk II by ANG_II in vascular smooth muscle cells .
11536198	0	Tyrosine	0,8	p190_RhoGAP	28,39	Tyrosine	p190 RhoGAP	CHEBI:18186	2909	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of p190_RhoGAP by Fyn regulates oligodendrocyte differentiation .
1879344	0	Tyrosine	0,8	p34cdc2	28,35	Tyrosine	p34cdc2	CHEBI:18186	379785(Tax:8355)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of p34cdc2 and p42 during meiotic maturation of Xenopus oocyte .
7543054	0	Tyrosine	0,8	p34cdc2	28,35	Tyrosine	p34cdc2	CHEBI:18186	379785(Tax:8355)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of p34cdc2 is regulated by protein phosphatase_2A in growing immature Xenopus oocytes .
26466383	0	Tyrosine	4,12	p38	63,66	Tyrosine	p38	D014443	81649(Tax:10116)	Chemical	Gene	Activation|compound|START_ENTITY Activation|nmod|END_ENTITY	Src Tyrosine Kinase Activation by 4-Hydroxynonenal Upregulates p38 , ERK/AP -1 Signaling and COX-2 Expression in YPEN-1 Cells .
9196032	0	Tyrosine	0,8	p38	28,31	Tyrosine	p38	CHEBI:18186	5594	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of p38 but not extracellular_signal-regulated_kinase in normal human neutrophils stimulated by tumor_necrosis_factor : comparative study with granulocyte-macrophage_colony-stimulating_factor .
7505449	0	Tyrosine	0,8	p56lck	43,49	Tyrosine	p56lck	CHEBI:18186	16818(Tax:10090)	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Tyrosine kinase activity of CD4-associated p56lck may not be required for CD4-dependent T-cell activation .
10202139	0	Tyrosine	0,8	p62	28,31	Tyrosine	p62	CHEBI:18186	23636	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of p62 -LRB- Dok -RRB- induced by cell adhesion and insulin : possible role in cell migration .
10688886	0	Tyrosine	0,8	p62dok	28,34	Tyrosine	p62dok	CHEBI:18186	1796	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of p62dok by p210bcr-abl inhibits RasGAP activity .
9874495	0	Tyrosine	0,8	p72syk	28,34	Tyrosine	p72syk	CHEBI:18186	6850	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of p72syk induced by anti-9-O-acetyl GD3 antibodies in human peripheral blood mononuclear cells .
11337495	0	Tyrosine	0,8	p85	28,31	Tyrosine	p85	CHEBI:18186	5296	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of p85 relieves its inhibitory activity on phosphatidylinositol 3-kinase .
10762642	0	Tyrosine	0,8	p90	46,49	Tyrosine	p90	CHEBI:18186	57650	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|protein protein|amod|END_ENTITY	Tyrosine phosphorylation of an erbB-2 related p90 protein induced by estrogen in human breast epithelial cells .
11087817	0	Tyrosine	0,8	p97	28,31	Tyrosine	p97	CHEBI:18186	4241	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of p97 regulates transitional endoplasmic reticulum assembly in vitro .
1385444	0	Tyrosine	0,8	paxillin	28,36	Tyrosine	paxillin	CHEBI:18186	19303(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix : a role in cytoskeletal assembly .
8626373	0	Tyrosine	0,8	paxillin	52,60	Tyrosine	paxillin	CHEBI:18186	5829	Chemical	Gene	START_ENTITY|dobj|expression expression|nmod|END_ENTITY	Tyrosine phosphorylation and enhanced expression of paxillin during neuronal differentiation in vitro .
8944643	0	Tyrosine	0,8	paxillin	53,61	Tyrosine	paxillin	CHEBI:18186	5829	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of the dense plaque protein paxillin is regulated during smooth muscle contraction .
7510677	0	Tyrosine	0,8	phosphatase_2A	36,50	Tyrosine	phosphatase 2A	CHEBI:18186	19052(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of protein phosphatase_2A in response to growth stimulation and v-src transformation of fibroblasts .
7543054	0	Tyrosine	0,8	phosphatase_2A	60,74	Tyrosine	phosphatase 2A	CHEBI:18186	394301(Tax:8355)	Chemical	Gene	phosphorylation|amod|START_ENTITY regulated|nsubjpass|phosphorylation regulated|nmod|END_ENTITY	Tyrosine phosphorylation of p34cdc2 is regulated by protein phosphatase_2A in growing immature Xenopus oocytes .
2732223	0	Tyrosine	0,8	phospholipase_C-II	28,46	Tyrosine	phospholipase C-II	CHEBI:18186	281987(Tax:9913)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of phospholipase_C-II in vitro by the epidermal_growth_factor_receptor .
1373507	0	Tyrosine	0,8	phospholipase_C-gamma_1	28,51	Tyrosine	phospholipase C-gamma 1	CHEBI:18186	5335	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of phospholipase_C-gamma_1 induced by cross-linking of the high-affinity or low-affinity Fc receptor for IgG in U937 cells .
7517665	0	Tyrosine	0,8	phospholipase_C-gamma_2	28,51	Tyrosine	phospholipase C-gamma 2	CHEBI:18186	5336	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of phospholipase_C-gamma_2 is involved in the activation of phosphoinositide hydrolysis by Fc receptors in human neutrophils .
15722193	0	Tyrosine	0,8	phospholipase_D1	28,44	Tyrosine	phospholipase D1	CHEBI:18186	18805(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of phospholipase_D1 by v-Src does not per se result in activation .
9084985	0	Tyrosine	0,8	platelet_endothelial_cell_adhesion_molecule-1	28,73	Tyrosine	platelet endothelial cell adhesion molecule-1	CHEBI:18186	282303(Tax:9913)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of platelet_endothelial_cell_adhesion_molecule-1 -LRB- PECAM-1 , CD31 -RRB- in mechanically stimulated vascular endothelial cells .
9501020	0	Tyrosine	0,8	platelet_endothelial_cell_adhesion_molecule-1	28,73	Tyrosine	platelet endothelial cell adhesion molecule-1	CHEBI:18186	282303(Tax:9913)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of platelet_endothelial_cell_adhesion_molecule-1 induced by lysophosphatidylcholine in cultured endothelial cells .
7514181	0	Tyrosine	0,8	pp125FAK	28,36	Tyrosine	pp125FAK	CHEBI:18186	5747	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of pp125FAK in platelets requires coordinated signaling through integrin and agonist receptors .
8408291	0	Tyrosine	0,8	pp125FAK	54,62	Tyrosine	pp125FAK	CHEBI:18186	5747	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of the focal adhesion kinase pp125FAK during development : relation to paxillin .
8463210	0	Tyrosine	0,8	pp125FAK	28,36	Tyrosine	pp125FAK	CHEBI:18186	25614(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of pp125FAK by the aggregation of high affinity immunoglobulin E receptors requires cell adherence .
2468662	0	Tyrosine	0,8	pp185	28,33	Tyrosine	pp185	CHEBI:18186	25467(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of pp185 by insulin_receptor kinase in a cell-free system .
7516061	0	Tyrosine	0,8	pp60c-src	30,39	Tyrosine	pp60c-src	CHEBI:18186	20779(Tax:10090)	Chemical	Gene	dephosphorylation|amod|START_ENTITY dephosphorylation|nmod|END_ENTITY	Tyrosine dephosphorylation of pp60c-src is stimulated by a serine/threonine phosphatase inhibitor .
9312112	0	Tyrosine	0,8	prolactin_receptor	34,52	Tyrosine	prolactin receptor	CHEBI:18186	24684(Tax:10116)	Chemical	Gene	sites|amod|START_ENTITY sites|nmod|END_ENTITY	Tyrosine docking sites of the rat prolactin_receptor required for association and activation of stat5 .
7507923	0	Tyrosine	0,8	protein_kinase_C-delta	28,50	Tyrosine	protein kinase C-delta	CHEBI:18186	5580	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of protein_kinase_C-delta in response to its activation .
7568083	0	Tyrosine	0,8	protein_kinase_C-delta	28,50	Tyrosine	protein kinase C-delta	CHEBI:18186	5580	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of protein_kinase_C-delta in response to the activation of the high-affinity receptor for immunoglobulin E modifies its substrate recognition .
7516899	0	Tyrosine	0,8	protein_kinase_C_delta	44,66	Tyrosine	protein kinase C delta	CHEBI:18186	5580	Chemical	Gene	START_ENTITY|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation and stimulation of protein_kinase_C_delta from porcine spleen by src in vitro .
11739733	0	Tyrosine	0,8	protein_kinase_Cdelta	28,49	Tyrosine	protein kinase Cdelta	CHEBI:18186	5580	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of protein_kinase_Cdelta is essential for its apoptotic effect in response to etoposide .
12637538	0	Tyrosine	0,8	protein_kinase_D	28,44	Tyrosine	protein kinase D	CHEBI:18186	5587	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of protein_kinase_D in the pleckstrin homology domain leads to activation .
21865166	0	Tyrosine	0,8	protein_kinase_D2	28,45	Tyrosine	protein kinase D2	CHEBI:18186	5311	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of protein_kinase_D2 mediates ligand-inducible elimination of the Type 1 interferon receptor .
22195962	0	Tyrosine	0,8	pyruvate_dehydrogenase	42,64	Tyrosine	pyruvate dehydrogenase	CHEBI:18186	54704	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of mitochondrial pyruvate_dehydrogenase kinase 1 is important for cancer metabolism .
9099734	0	Tyrosine	0,8	related_adhesion_focal_tyrosine_kinase	32,70	Tyrosine	related adhesion focal tyrosine kinase	CHEBI:18186	2185	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of the related_adhesion_focal_tyrosine_kinase in megakaryocytes upon stem_cell_factor and phorbol_myristate_acetate stimulation and its association with paxillin .
14766744	0	Tyrosine	0,8	ret	22,25	Tyrosine	ret	CHEBI:18186	5979	Chemical	Gene	START_ENTITY|appos|site site|compound|END_ENTITY	Tyrosine 981 , a novel ret autophosphorylation site , binds c-Src to mediate neuronal survival .
7685595	0	Tyrosine	0,8	ret	32,35	Tyrosine	ret	CHEBI:18186	5979	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|dobj|activity activity|nmod|products products|amod|END_ENTITY	Tyrosine kinase activity of the ret proto-oncogene products in vitro .
16179349	0	Tyrosine	0,8	sam68	28,33	Tyrosine	sam68	CHEBI:18186	10657	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of sam68 by breast_tumor_kinase regulates intranuclear localization and cell cycle progression .
21992875	0	Tyrosine	0,8	serotonin_transporter	38,59	Tyrosine	serotonin transporter	D014443	6532	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of the human serotonin_transporter : a role in the transporter stability and function .
12937607	0	Tyrosine	0,8	src	16,19	Tyrosine	src	CHEBI:18186	6714	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Tyrosine kinase src inhibitors : potential therapeutic applications .
9099734	0	Tyrosine	0,8	stem_cell_factor	94,110	Tyrosine	stem cell factor	CHEBI:18186	4254	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|megakaryocytes megakaryocytes|nmod|stimulation stimulation|compound|END_ENTITY	Tyrosine phosphorylation of the related_adhesion_focal_tyrosine_kinase in megakaryocytes upon stem_cell_factor and phorbol_myristate_acetate stimulation and its association with paxillin .
20530578	0	Tyrosine	0,8	synapsin_I	28,38	Tyrosine	synapsin I	CHEBI:18186	6853	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of synapsin_I by Src regulates synaptic-vesicle trafficking .
16246116	0	Tyrosine	0,8	synaptophysin	28,41	Tyrosine	synaptophysin	CHEBI:18186	6855	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of synaptophysin in synaptic vesicle recycling .
16630467	0	Tyrosine	1,9	thrombin	79,87	Tyrosine	thrombin	CHEBI:18186	280685(Tax:9913)	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|nmod|Xa Xa|compound|END_ENTITY	-LSB- Tyrosine kinase dependent lectin-like_oxidized_LDL_receptor-1 upregulation by thrombin and factor Xa in vascular smooth muscle cells -RSB- .
7781604	0	Tyrosine	0,8	thrombin	98,106	Tyrosine	thrombin	CHEBI:18186	2147	Chemical	Gene	phosphorylation|amod|START_ENTITY coupled|nsubjpass|phosphorylation coupled|xcomp|platelet platelet|dobj|receptor receptor|compound|END_ENTITY	Tyrosine phosphorylation of an SH2-containing protein tyrosine phosphatase is coupled to platelet thrombin receptor via a pertussis toxin-sensitive heterotrimeric G-protein .
8297360	0	Tyrosine	0,8	thrombin	80,88	Tyrosine	thrombin	CHEBI:18186	2147	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|kinases kinases|nmod|END_ENTITY	Tyrosine phosphorylation and activation of mitogen-activated protein kinases by thrombin in human platelets : possible involvement in late arachidonic_acid release .
1315765	0	Tyrosine	0,8	tissue-type_plasminogen_activator	58,91	Tyrosine	tissue-type plasminogen activator	CHEBI:18186	25692(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Tyrosine 67 in the epidermal growth factor-like domain of tissue-type_plasminogen_activator is important for clearance by a specific hepatic receptor .
17228323	0	Tyrosine	0,8	toll-like_receptor_4	36,56	Tyrosine	toll-like receptor 4	CHEBI:18186	7099	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|advcl|END_ENTITY	Tyrosine kinase Syk associates with toll-like_receptor_4 and regulates signaling in human monocytic cells .
23365450	0	Tyrosine	0,8	triple_gene_block_protein_3	32,59	Tyrosine	triple gene block protein 3	CHEBI:18186	991176(Tax:37128)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of the triple_gene_block_protein_3 regulates cell-to-cell movement and protein interactions of Potato_mop-top_virus .
1706478	0	Tyrosine	0,8	trk	61,64	Tyrosine	trk	CHEBI:18186	4914	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|product product|amod|END_ENTITY	Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF .
10455176	0	Tyrosine	0,8	tub	28,31	Tyrosine	tub	CHEBI:18186	25609(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of tub and its association with Src homology 2 domain-containing proteins implicate tub in intracellular signaling by insulin .
18551654	0	Tyrosine	0,8	tyrosinase	45,55	Tyrosine	tyrosinase	CHEBI:18186	7299	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Tyrosine hydroxylase activity of immobilized tyrosinase on enzacryl-AA and CPG-AA supports : Stabilization and properties .
5871805	0	Tyrosine	0,8	tyrosinase	46,56	Tyrosine	tyrosinase	CHEBI:18186	7299	Chemical	Gene	hydroxylation|amod|START_ENTITY hydroxylation|acl|catalyzed catalyzed|nmod|END_ENTITY	Tyrosine hydroxylation catalyzed by mammalian tyrosinase : an improved method of assay .
1901800	0	Tyrosine	0,8	urokinase-type_plasminogen_activator	34,70	Tyrosine	urokinase-type plasminogen activator	CHEBI:18186	5328	Chemical	Gene	START_ENTITY|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of human urokinase-type_plasminogen_activator .
12219009	0	Tyrosine	0,8	vascular_endothelial_cadherin	28,57	Tyrosine	vascular endothelial cadherin	CHEBI:18186	1003	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of vascular_endothelial_cadherin and the regulation of microvascular permeability .
1375396	0	Tyrosine	0,8	vav	32,35	Tyrosine	vav	CHEBI:18186	7409	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|product product|amod|END_ENTITY	Tyrosine phosphorylation of the vav proto-oncogene product in activated B cells .
1531699	0	Tyrosine	0,8	vav	28,31	Tyrosine	vav	CHEBI:18186	7409	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|product product|amod|END_ENTITY	Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs .
9099726	0	Tyrosine	0,8	vav	32,35	Tyrosine	vav	CHEBI:18186	7409	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|product product|amod|END_ENTITY	Tyrosine phosphorylation of the vav proto-oncogene product links FcepsilonRI to the Rac1-JNK pathway .
20678470	0	Tyrosine	0,8	vinculin	28,36	Tyrosine	vinculin	CHEBI:18186	7414	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of vinculin at position 1065 modifies focal adhesion dynamics and cell tractions .
9552386	0	Tyrosine	0,8	wee1	17,21	Tyrosine	wee1	CHEBI:18186	853252(Tax:4932)	Chemical	Gene	kinases|nsubj|START_ENTITY kinases|dobj|END_ENTITY	Tyrosine kinases wee1 and mik1 as effectors of DNA replication checkpoint control .
8892604	0	Tyrosines	0,9	SLP-76	31,37	Tyrosines	SLP-76	null	3937	Chemical	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	Tyrosines 113 , 128 , and 145 of SLP-76 are required for optimal augmentation of NFAT promoter activity .
22305891	0	Tyrosines	0,9	Spred2	59,65	Tyrosines	Spred2	null	200734	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Tyrosines 303/343/353 within the Sprouty-related domain of Spred2 are essential for its interaction with p85 and inhibitory effect on Ras/ERK activation .
19800237	0	Tyrosines	0,9	kinesin-5	17,26	Tyrosines	kinesin-5	null	38135(Tax:7227)	Chemical	Gene	START_ENTITY|nmod|domain domain|amod|END_ENTITY	Tyrosines in the kinesin-5 head domain are necessary for phosphorylation by Wee1 and for mitotic spindle integrity .
12923167	0	Tyrosyl	0,7	Shp2	27,31	Tyrosyl	Shp2	CHEBI:37898	5781	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some , but not all , growth factors .
7118417	0	Tyrosyl	0,7	carboxypeptidase_B	43,61	Tyrosyl	carboxypeptidase B	CHEBI:37898	57094	Chemical	Gene	interactions|amod|START_ENTITY interactions|nmod|END_ENTITY	Tyrosyl interactions at the active site of carboxypeptidase_B .
1718436	0	Tyrosyl	0,7	myelin_basic_protein	46,66	Tyrosyl	myelin basic protein	CHEBI:37898	17196(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosyl phosphorylation and activation of the myelin_basic_protein kinase p44mpk during sea star oocyte maturation .
12126792	0	Tyrosyl	0,7	myeloperoxidase	30,45	Tyrosyl	myeloperoxidase	CHEBI:37898	4353	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Tyrosyl radical production by myeloperoxidase : a phagocyte pathway for lipid peroxidation and dityrosine cross-linking of proteins .
8051134	0	Tyrosyl	0,7	myeloperoxidase	29,44	Tyrosyl	myeloperoxidase	CHEBI:37898	4353	Chemical	Gene	radical|compound|START_ENTITY radical|acl|generated generated|nmod|END_ENTITY	Tyrosyl radical generated by myeloperoxidase is a physiological catalyst for the initiation of lipid peroxidation in low density lipoprotein .
8390491	0	Tyrosyl	0,7	myeloperoxidase	29,44	Tyrosyl	myeloperoxidase	CHEBI:37898	4353	Chemical	Gene	radical|compound|START_ENTITY generated|nsubj|radical generated|nmod|catalyzes catalyzes|amod|END_ENTITY	Tyrosyl radical generated by myeloperoxidase catalyzes the oxidative cross-linking of proteins .
25999739	0	Tyrphostin_AG1296	0,17	platelet-derived_growth_factor_receptor	21,60	Tyrphostin AG1296	platelet-derived growth factor receptor	MESH:C106250	5159	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Tyrphostin_AG1296 , a platelet-derived_growth_factor_receptor inhibitor , induces apoptosis , and reduces viability and migration of PLX4032-resistant melanoma cells .
25999739	0	Tyrphostin_AG1296	0,17	platelet-derived_growth_factor_receptor	21,60	Tyrphostin AG1296	platelet-derived growth factor receptor	MESH:C106250	5159	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Tyrphostin_AG1296 , a platelet-derived_growth_factor_receptor inhibitor , induces apoptosis , and reduces viability and migration of PLX4032-resistant melanoma cells .
10229872	0	Tyrphostin_B42	0,14	Janus_kinase-2	81,95	Tyrphostin B42	Janus kinase-2	MESH:C095512	16452(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Tyrphostin_B42 inhibits IL-12-induced tyrosine phosphorylation and activation of Janus_kinase-2 and prevents experimental_allergic_encephalomyelitis .
7121609	0	U-0521	43,49	Catechol-O-methyltransferase	0,28	U-0521	Catechol-O-methyltransferase	MESH:C006104	24267(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Catechol-O-methyltransferase inhibition by U-0521 increases striatal utilization of levodopa .
7150363	0	U-0521	51,57	catechol-O-methyltransferase	62,90	U-0521	catechol-O-methyltransferase	MESH:C006104	24267(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|cells cells|nmod|activity activity|amod|END_ENTITY	Effect of 3 ' ,4 ' - dihydroxy-2-methyl-propriophenone -LRB- U-0521 -RRB- on catechol-O-methyltransferase activity and on DOPA accumulation in rat red blood cells and corpus striatum .
8968364	0	U-101387	36,44	dopamine_D4_receptor	48,68	U-101387	dopamine D4 receptor	MESH:C100448	1815	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Pharmacological characterization of U-101387 , a dopamine_D4_receptor selective antagonist .
8119318	0	U-46619	71,78	thromboxane_A2_receptor	38,61	U-46619	thromboxane A2 receptor	MESH:D019796	24816(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Possible involvement of endothelin in thromboxane_A2_receptor agonist -LRB- U-46619 -RRB- - induced angina in the rat .
15684042	0	U-73122	44,51	5-lipoxygenase	164,178	U-73122	5-lipoxygenase	MESH:C060229	240	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	The aminosteroid phospholipase C antagonist U-73122 -LRB- 1 - -LSB- 6 - -LSB- -LSB- 17-beta-3-methoxyestra-1 ,3,5 -LRB- 10 -RRB- - trien-17-yl -RSB- amino -RSB- hexyl -RSB- -1 H-pyrrole-2 ,5 - dione -RRB- potently inhibits human 5-lipoxygenase in vivo and in vitro .
8088342	0	U-92032	0,7	Ca2	18,21	U-92032	Ca2	MESH:C086422	12349(Tax:10090)	Chemical	Gene	START_ENTITY|appos|blocker blocker|amod|END_ENTITY	U-92032 , a T-type Ca2 + channel blocker and antioxidant , reduces neuronal ischemic_injuries .
9065866	0	U-92032	24,31	Ca2	53,56	U-92032	Ca2	MESH:C086422	54231(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|channels channels|amod|END_ENTITY	Ca2 + channel antagonist U-92032 inhibits both T-type Ca2 + channels and Na + channels in hippocampal CA1 pyramidal neurons .
7564332	0	U-97018	11,18	angiotensin_II	82,96	U-97018	angiotensin II	MESH:C095796	24179(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of U-97018 on pressor responses to intracerebroventricularly administered angiotensin_II in conscious normotensive rats .
26855970	0	U0126	0,5	Interleukin-6	92,105	U0126	Interleukin-6	MESH:C113580	3569	Chemical	Gene	START_ENTITY|nmod|Apoptosis Apoptosis|amod|END_ENTITY	U0126 , an Inhibitor of MEK1/2 , Increases Tumor_Necrosis Factor-a-Induced Apoptosis , but not Interleukin-6 Induced Apoptosis in C-28 / I2 Human Chondrocytes .
22940059	4	U0126	750,755	JNK	772,775	U0126	p38	MESH:C113580	5594	Chemical	Gene	p38|dep|START_ENTITY SB203580|dep|p38 SB203580|dep|END_ENTITY	When the activity of MAPKs was blocked by their corresponding inhibitors -LRB- SB203580 : p38 ; U0126 : ERK ; SP600125 : JNK -RRB- , the expression of TF was reduced significantly .
9820549	5	U0126	634,639	LPS	611,614	U0126	p38	MESH:C113580	5594	Chemical	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	Treatment of monocytes with LPS in the presence of U0126 blocked the activation of ERK1 and ERK2 .
12963974	0	U0126	17,22	MEK	2,5	U0126	MEK	MESH:C113580	17242(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	A MEK inhibitor -LRB- U0126 -RRB- prolongs survival in nude_mice bearing human gallbladder_cancer cells with K-ras mutation : analysis in a novel orthotopic inoculation model .
14576498	0	U0126	48,53	MEK	0,3	U0126	MEK	MESH:C113580	5609	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|END_ENTITY	MEK inhibition of pancreatic_carcinoma cells by U0126 and its effect in combination with sulindac .
15743030	0	U0126	17,22	MEK	2,5	U0126	MEK	MESH:C113580	5609	Chemical	Gene	inhibitor|appos|START_ENTITY markedly|nmod:npmod|inhibitor inhibits|advmod|markedly inhibits|nsubj|END_ENTITY	A MEK inhibitor -LRB- U0126 -RRB- markedly inhibits direct liver invasion of orthotopically inoculated human gallbladder_cancer cells in nude_mice .
23320839	8	U0126	1228,1233	MEK	1212,1215	U0126	MEK	MESH:C113580	5609	Chemical	Gene	inhibitors|appos|START_ENTITY inhibitors|compound|END_ENTITY	RESULTS : Both Raf1 inhibitor -LRB- GW5074 -RRB- and MEK inhibitors -LRB- U0126 and AZD6244 -RRB- suppressed HCC cell growth in a dose dependent manner .
9873633	0	U0126	57,62	MEK	0,3	U0126	MEK	MESH:C113580	5609	Chemical	Gene	activity|nmod|START_ENTITY inhibitors|dep|activity inhibitors|compound|END_ENTITY	MEK inhibitors : the chemistry and biological activity of U0126 , its analogs , and cyclization products .
24726849	7	U0126	1202,1207	MEK1/2	1233,1239	U0126	ERK1/2	MESH:C113580	5595;5594	Chemical	Gene	use|nmod|START_ENTITY use|appos|inhibitor inhibitor|nmod|END_ENTITY	The use of U0126 , a specific inhibitor of MEK1/2 , proved that H2O2-induced decrease of occludin in EA.hy926 cells was likely associated with activation of ERK1/2 , which indicated that the regulation of farrerol on occludin expression in H2O2-induced EA.hy926 cells was likely related to the modulation of ERK1/2 activation .
26855970	0	U0126	0,5	MEK1/2	23,29	U0126	MEK1/2	MESH:C113580	5604;5605	Chemical	Gene	START_ENTITY|appos|Inhibitor Inhibitor|nmod|END_ENTITY	U0126 , an Inhibitor of MEK1/2 , Increases Tumor_Necrosis Factor-a-Induced Apoptosis , but not Interleukin-6 Induced Apoptosis in C-28 / I2 Human Chondrocytes .
24819614	0	U0126	0,5	MEK1_and_2	58,68	U0126	MEK1 and 2	MESH:C113580	5604;5605	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|appos|END_ENTITY	U0126 , a mitogen-activated_protein_kinase_kinase_1_and_2 -LRB- MEK1_and_2 -RRB- inhibitor , selectively up-regulates main isoforms of CYP3A subfamily via a pregnane_X_receptor -LRB- PXR -RRB- in HepG2 cells .
19726282	0	U0126	54,59	aquaporin_4	63,74	U0126	aquaporin 4	MESH:C113580	25293(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effect of MAPK signal transduction pathway inhibitor U0126 on aquaporin_4 expression in alveolar_type_II cells in rats with oleic_acid-induced acute_lung_injury -RSB- .
24819614	0	U0126	0,5	mitogen-activated_protein_kinase_kinase_1_and_2	9,56	U0126	mitogen-activated protein kinase kinase 1 and 2	MESH:C113580	5604;5605	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	U0126 , a mitogen-activated_protein_kinase_kinase_1_and_2 -LRB- MEK1_and_2 -RRB- inhibitor , selectively up-regulates main isoforms of CYP3A subfamily via a pregnane_X_receptor -LRB- PXR -RRB- in HepG2 cells .
12508271	4	U0126	605,610	p38	494,497	U0126	ERK	MESH:C113580	5594	Chemical	Gene	inhibitor|appos|START_ENTITY enhanced|nsubj|inhibitor prevented|advcl|enhanced prevented|nsubj|inhibitor inhibitor|amod|END_ENTITY	p38 inhibitor -LRB- SB203580 -RRB- prevented CsA-induced hemoglobin synthesis in K562 cells , although MEK/ERK inhibitor -LRB- U0126 -RRB- enhanced it by 3.3 times in K562 cells .
16478922	7	U0126	870,875	p38	979,982	U0126	Erk	MESH:C113580	5594	Chemical	Gene	able|nsubj|START_ENTITY able|ccomp|mediates mediates|nsubj|END_ENTITY	Furthermore the Erk inhibitor U0126 was able to counteract the effect of p38 inhibition on IL-2 production , supporting the conclusion that p38 mediates its effect through Erk .
26980390	9	U0126	1414,1419	p38	1458,1461	U0126	p38	MESH:C113580	5594	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	SYK-induced MUC5AC expression was significantly attenuated by pretreatment with U0126 -LRB- ERK1/2 MAPK inhibitor -RRB- and SB203580 -LRB- p38 MAPK inhibitor -RRB- .
8250947	0	U44069	70,76	p72syk	24,30	U44069	p72syk	MESH:C028429	6850	Chemical	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	Protein-tyrosine kinase p72syk is activated by thromboxane_A2 mimetic U44069 in platelets .
9291137	0	U46619	100,106	cyclo-oxygenase-2	52,69	U46619	cyclo-oxygenase-2	MESH:D019796	5743	Chemical	Gene	analogue|appos|START_ENTITY END_ENTITY|nmod|analogue	Regulatory role of prostaglandin_E2 in induction of cyclo-oxygenase-2 by a thromboxane_A2 analogue -LRB- U46619 -RRB- and basic fibroblast_growth_factor in porcine aortic smooth-muscle cells .
25815340	0	U50488	71,77	Kappa-Opioid_Receptor	40,61	U50488	Kappa-Opioid Receptor	MESH:D019900	100135587(Tax:10141)	Chemical	Gene	Agonist|appos|START_ENTITY Agonist|compound|END_ENTITY	The Differential Effects of a Selective Kappa-Opioid_Receptor Agonist , U50488 , in Guinea_Pig Heart Tissues .
11526958	0	U69593	45,51	kappa-opioid_receptor	14,35	U69593	kappa-opioid receptor	MESH:C045444	4986	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Effect of the kappa-opioid_receptor agonist , U69593 , on reinstatement of extinguished amphetamine self-administration behavior .
23178182	0	UCCB01-125	0,10	PSD-95	35,41	UCCB01-125	PSD-95	null	1742	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	UCCB01-125 , a dimeric inhibitor of PSD-95 , reduces inflammatory_pain without disrupting cognitive or motor performance : comparison with the NMDA receptor antagonist MK-801 .
18595696	0	UCCF-029	22,30	CFTR	14,18	UCCF-029	CFTR	MESH:C527579	12638(Tax:10090)	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of CFTR by UCCF-029 and genistein .
11953432	7	UCN-01	1132,1138	Chk1/2	1148,1154	UCN-01	Cdc25C	MESH:C054852	995	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	UCN-01 inhibits Chk1/2 , which should activate the mitosis-inducing phosphatase Cdc25C , yet this phosphatase remained inactive during S phase progression induced by low concentrations of UCN-01 , probably because Cdc25C is also inhibited by the constitutive kinase , C-TAK1 .
15069549	0	UCN-01	14,20	Mrp2	61,65	UCN-01	Mrp2	MESH:C054852	25303(Tax:10116)	Chemical	Gene	Metabolism|nmod|START_ENTITY Metabolism|dep|role role|nmod|END_ENTITY	Metabolism of UCN-01 in isolated perfused rat liver : role of Mrp2 in the biliary excretion of glucuronides .
12384533	0	UCN-01	0,6	p53	16,19	UCN-01	p53	MESH:C054852	7157	Chemical	Gene	up-regulation|compound|START_ENTITY up-regulation|compound|END_ENTITY	UCN-01 inhibits p53 up-regulation and abrogates gamma-radiation-induced G -LRB- 2 -RRB- - M checkpoint independently of p53 by targeting both of the checkpoint kinases , Chk2 and Chk1 .
25016091	0	UCN-01	59,65	phosphoinositide-dependent_protein_kinase_1	4,47	UCN-01	phosphoinositide-dependent protein kinase 1	MESH:C054852	5163	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	The phosphoinositide-dependent_protein_kinase_1 inhibitor , UCN-01 , induces fragmentation : possible role of metalloproteinases .
23537372	0	UCN-01	0,6	waf1	64,68	UCN-01	waf1	MESH:C054852	1026	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	UCN-01 induces S and G2/M cell cycle arrest through the p53/p21 -LRB- waf1 -RRB- or CHK2/CDC25C pathways and can suppress invasion in human hepatoma cell lines .
18252808	0	UDP	0,3	P2Y14_receptor	45,59	UDP	P2Y14 receptor	MESH:D014530	9934	Chemical	Gene	antagonist|nsubj|START_ENTITY antagonist|nmod|END_ENTITY	UDP is a competitive antagonist at the human P2Y14_receptor .
17410128	0	UDP	0,3	P2Y6	14,18	UDP	P2Y6	MESH:D014530	117264(Tax:10116)	Chemical	Gene	START_ENTITY|acl|acting acting|nmod|receptors receptors|nummod|END_ENTITY	UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis .
19262132	0	UDP	0,3	P2Y6	48,52	UDP	P2Y6	MESH:D014530	117264(Tax:10116)	Chemical	Gene	facilitates|nsubj|START_ENTITY facilitates|nmod|receptors receptors|nummod|END_ENTITY	UDP facilitates microglial phagocytosis through P2Y6 receptors .
24123515	0	UDP	36,39	P2Y6	31,35	UDP	P2Y6	MESH:D014530	5031	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Inhibition of P2X4 function by P2Y6 UDP receptors in microglia .
9052741	0	UDP	29,32	UGT2B1	57,63	UDP	UGT2B1	MESH:D014530	286954(Tax:10116)	Chemical	Gene	promoter|compound|START_ENTITY promoter|compound|END_ENTITY	HNF1_alpha activates the rat UDP glucuronosyltransferase UGT2B1 gene promoter .
9614204	0	UDP	33,36	UGT2B1	61,67	UDP	UGT2B1	MESH:D014530	71773(Tax:10090)	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	C/EBPalpha is a regulator of the UDP glucuronosyltransferase UGT2B1 gene .
23842869	0	UDP-GlcNAc	0,10	GNE	38,41	UDP-GlcNAc	GNE	CHEBI:16264	10020	Chemical	Gene	Kinase|compound|START_ENTITY Kinase|appos|END_ENTITY	UDP-GlcNAc 2-Epimerase/ManNAc Kinase -LRB- GNE -RRB- : A Master Regulator of Sialic_Acid Synthesis .
19954973	0	UK-396082	24,33	thrombin_activatable_fibrinolysis_inhibitor	61,104	UK-396082	thrombin activatable fibrinolysis inhibitor	MESH:C526817	1361	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Oxygenated analogues of UK-396082 as inhibitors of activated thrombin_activatable_fibrinolysis_inhibitor .
10710122	0	UR-7247	25,32	angiotensin_II	51,65	UR-7247	angiotensin II	MESH:C406274	183	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Pharmacologic profile of UR-7247 , an orally active angiotensin_II AT1 receptor antagonist , in healthy volunteers .
19698735	0	URB-597	16,23	FAAH	0,4	URB-597	FAAH	MESH:C500528	29347(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	FAAH inhibitor , URB-597 , promotes extinction and CB -LRB- 1 -RRB- antagonist , SR141716 , inhibits extinction of conditioned aversion produced by naloxone-precipitated morphine withdrawal , but not extinction of conditioned preference produced by morphine in rats .
20802454	0	URB597	11,17	FAAH	63,67	URB597	FAAH	MESH:C500528	14073(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of URB597 , an inhibitor of fatty_acid_amide hydrolase -LRB- FAAH -RRB- , on analgesic activity of paracetamol .
24037493	0	URB597	52,58	fatty_acid_amide_hydrolase	15,41	URB597	fatty acid amide hydrolase	MESH:C500528	14073(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Effects of the fatty_acid_amide_hydrolase inhibitor URB597 on coping behavior under challenging conditions in mice .
25106694	0	URB597	102,108	fatty_acid_amide_hydrolase	65,91	URB597	fatty acid amide hydrolase	MESH:C500528	2166	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|amygdala amygdala|acl|mediating mediating|dobj|effects effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Role of the basolateral amygdala in mediating the effects of the fatty_acid_amide_hydrolase inhibitor URB597 on HPA_axis response to stress .
18096504	0	URB602	0,6	monoacylglycerol_lipase	16,39	URB602	monoacylglycerol lipase	MESH:C501835	29254(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	URB602 inhibits monoacylglycerol_lipase and selectively blocks 2-arachidonoylglycerol degradation in intact brain slices .
21982493	0	URB602	57,63	monoacylglycerol_lipase	87,110	URB602	monoacylglycerol lipase	MESH:C501835	11343	Chemical	Gene	evaluation|nmod|START_ENTITY analogues|nsubj|evaluation analogues|nmod|inhibitors inhibitors|compound|END_ENTITY	The design , synthesis and biological evaluation of novel URB602 analogues as potential monoacylglycerol_lipase inhibitors .
23271561	0	UTP	38,41	N-cadherin	0,10	UTP	N-cadherin	MESH:D014544	1000	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	N-cadherin expression is regulated by UTP in schwannoma cells .
10494890	0	UTP	37,40	P2Y2	53,57	UTP	P2Y2	MESH:D014544	29597(Tax:10116)	Chemical	Gene	receptor|nmod|START_ENTITY receptor|dep|END_ENTITY	A contraction-mediating receptor for UTP , presumably P2Y2 , in rat vas deferens .
17079144	0	UTP	84,87	P2Y2	41,45	UTP	P2Y2	MESH:D014544	5029	Chemical	Gene	stability|nmod|START_ENTITY agonists|nmod|stability agonists|nsubj|nucleotide_triphosphates nucleotide_triphosphates|nmod|END_ENTITY	Novel nucleotide_triphosphates as potent P2Y2 agonists with enhanced stability over UTP .
20471392	0	UTP	22,25	P2Y2	97,101	UTP	P2Y2	MESH:D014544	29597(Tax:10116)	Chemical	Gene	Uridine_triphosphate|appos|START_ENTITY induces|nsubj|Uridine_triphosphate induces|nmod|activation activation|nmod|receptors receptors|nummod|END_ENTITY	Uridine_triphosphate -LRB- UTP -RRB- induces profibrotic responses in cardiac fibroblasts by activation of P2Y2 receptors .
9446569	0	UTP	32,35	P2Y2	14,18	UTP	P2Y2	MESH:D014544	29597(Tax:10116)	Chemical	Gene	receptors|nmod|START_ENTITY receptors|nummod|END_ENTITY	Activation of P2Y2 receptors by UTP and ATP stimulates mitogen-activated kinase activity through a pathway that involves related adhesion focal tyrosine kinase and protein kinase C .
15047214	0	Ubiquinol	0,9	UQCRFS1	34,41	Ubiquinol	UQCRFS1	MESH:C003741	7386	Chemical	Gene	reductase|amod|START_ENTITY reductase|appos|END_ENTITY	Ubiquinol cytochrome_c reductase -LRB- UQCRFS1 -RRB- gene amplification in primary breast_cancer core biopsy samples .
16597436	0	Ubiquinone	0,10	Qcr8p	95,100	Ubiquinone	Qcr8p	MESH:D014451	853273(Tax:4932)	Chemical	Gene	accumulates|amod|START_ENTITY mutated|nsubj|accumulates mutated|nmod|protein protein|appos|END_ENTITY	Ubiquinone accumulates in the mitochondria of yeast mutated in the ubiquinone binding protein , Qcr8p .
10217438	0	Ubiquinone	0,10	lipoamide_dehydrogenase	25,48	Ubiquinone	lipoamide dehydrogenase	MESH:D014451	1738	Chemical	Gene	reduced|nsubjpass|START_ENTITY reduced|nmod|END_ENTITY	Ubiquinone is reduced by lipoamide_dehydrogenase and this reaction is potently stimulated by zinc .
26875692	0	UiO-66	22,28	CO2	33,36	UiO-66	CO2	null	717	Chemical	Gene	START_ENTITY|nmod|uptake uptake|compound|END_ENTITY	Defect engineering of UiO-66 for CO2 and H2O uptake - a combined experimental and simulation study .
11700404	3	Ulinastatin	275,286	PMNE	319,323	Ulinastatin	PMNE	null	1991	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|amod|END_ENTITY	Ulinastatin , a protease inhibitor , inhibits PMNE release by blood transfusion .
17112827	0	Ulinastatin	0,11	tumor_necrosis_factor_alpha	78,105	Ulinastatin	tumor necrosis factor alpha	null	24835(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|advcl|inhibiting inhibiting|dobj|END_ENTITY	Ulinastatin attenuates lung_ischemia-reperfusion injury in rats by inhibiting tumor_necrosis_factor_alpha .
26474308	0	Ulipristal_Acetate	0,18	Progesterone_Receptor	28,49	Ulipristal Acetate	Progesterone Receptor	MESH:C555622	5241	Chemical	Gene	Isoform|compound|START_ENTITY Isoform|compound|END_ENTITY	Ulipristal_Acetate Inhibits Progesterone_Receptor Isoform A-Mediated Human Breast Cancer Proliferation and BCl2-L1 Expression .
22191422	0	Ultrafine	0,9	heme_oxygenase-1	66,82	Ultrafine	heme oxygenase-1	MESH:C043595	3162	Chemical	Gene	stress|compound|START_ENTITY stress|dep|role role|nmod|END_ENTITY	Ultrafine and nanoparticles-induced oxidative stress : the role of heme_oxygenase-1 and carbon_monoxide as anti-inflammatory pathways .
26560897	0	Undecaprenyl-Pyrophosphate	80,106	BacA	75,79	Undecaprenyl-Pyrophosphate	BacA	MESH:C088139	10752080	Chemical	Gene	Phosphatase|compound|START_ENTITY Phosphatase|compound|END_ENTITY	Membrane Topology and Biochemical Characterization of the Escherichia_coli BacA Undecaprenyl-Pyrophosphate Phosphatase .
27053614	0	Unsaturated_fatty_acid	1,23	Nrf_2	162,167	Unsaturated fatty acid	Nrf 2	CHEBI:27208	83619(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|advcl|activating activating|dobj|END_ENTITY	-LSB- Unsaturated_fatty_acid of Actinidia chinesis Planch seed oil enhances the antioxidative stress ability of rats with pulmonary_fibrosis through activating Keap_1 / Nrf_2 signaling pathway -RSB- .
21413683	1	Ur	60,62	transferrin	73,84	Ur	transferrin	null	7018	Chemical	Gene	uptake|nsubj|START_ENTITY uptake|nmod|END_ENTITY	Ur uptake by transferrin .
6290958	0	Uracil	0,6	HCN	21,24	Uracil	HCN	MESH:D014498	378938	Chemical	Gene	synthesis|amod|START_ENTITY synthesis|nmod|END_ENTITY	Uracil synthesis via HCN oligomerization .
12355409	0	Uracil	150,156	dihydropyrimidine_dehydrogenase	20,51	Uracil	dihydropyrimidine dehydrogenase	MESH:D014498	1806	Chemical	Gene	UFT|appos|START_ENTITY efficacy|nmod|UFT regarding|dobj|efficacy regarding|nsubj|value value|nmod|expression expression|amod|END_ENTITY	Predictive value of dihydropyrimidine_dehydrogenase expression in tumor tissue , regarding the efficacy of postoperatively administered UFT -LRB- Tegafur + Uracil -RRB- in patients with p-stage I nonsmall-cell_lung_cancer .
14728979	0	Uranium	0,7	TNF_alpha	16,25	Uranium	TNF alpha	MESH:D014501	24835(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|secretion secretion|compound|END_ENTITY	Uranium induces TNF_alpha secretion and MAPK activation in a rat alveolar macrophage cell line .
11133526	0	Urea	0,4	ERK	18,21	Urea	ERK	MESH:D014508	5594	Chemical	Gene	START_ENTITY|acl|signaling signaling|xcomp|END_ENTITY	Urea signaling to ERK phosphorylation in renal medullary cells requires extracellular calcium but not calcium entry .
8476072	0	Urea	0,4	Egr-1	13,18	Urea	Egr-1	MESH:D014508	1958	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Urea induces Egr-1 and c-fos expression in renal epithelial cells .
9729519	0	Urea	0,4	FAK	38,41	Urea	FAK	MESH:D014508	14083(Tax:10090)	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	Urea and NaCl differentially regulate FAK and RAFTK/PYK2 in mIMCD3 renal medullary cells .
11292634	0	Urea	0,4	TonEBP	38,44	Urea	TonEBP	MESH:D014508	10725	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Urea inhibits hypertonicity-inducible TonEBP expression and action .
18945830	0	Urea	0,4	TonEBP	73,79	Urea	TonEBP	MESH:D014508	307820(Tax:10116)	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|transporter transporter|nmod|directions directions|nmod|END_ENTITY	Urea and NaCl regulate UT-A1 urea transporter in opposing directions via TonEBP pathway during osmotic diuresis .
24204711	0	Urea	0,4	UT-B	17,21	Urea	UT-B	MESH:D014508	108052(Tax:10090)	Chemical	Gene	deletion|compound|START_ENTITY deletion|compound|END_ENTITY	Urea transporter UT-B deletion induces DNA damage and apoptosis in mouse bladder urothelium .
9545259	0	Urea	0,4	UT3	17,20	Urea	UT3	MESH:D014508	54301(Tax:10116)	Chemical	Gene	transporter|nsubj|START_ENTITY transporter|dobj|functions functions|nummod|END_ENTITY	Urea transporter UT3 functions as an efficient water channel .
8662677	0	Urea	0,4	egr-1	21,26	Urea	egr-1	MESH:D014508	13653(Tax:10090)	Chemical	Gene	inducibility|compound|START_ENTITY inducibility|nmod|cells cells|amod|END_ENTITY	Urea inducibility of egr-1 in murine inner medullary collecting duct cells is mediated by the serum response element and adjacent Ets motifs .
2645501	0	Urea	0,4	growth_hormone	109,123	Urea	growth hormone	MESH:D014508	2688	Chemical	Gene	synthesis|compound|START_ENTITY END_ENTITY|nsubj|synthesis	Urea synthesis , nitrogen balance , and glucose_turnover in growth-hormone-deficient children before and after growth_hormone administration .
11592956	0	Urea	0,4	heme_oxygenase-1	46,62	Urea	heme oxygenase-1	MESH:D014508	15368(Tax:10090)	Chemical	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Urea and hypertonicity increase expression of heme_oxygenase-1 in murine renal medullary cells .
9458825	0	Urea	0,4	ribosomal_S6_kinase	15,34	Urea	ribosomal S6 kinase	MESH:D014508	20111(Tax:10090)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Urea activates ribosomal_S6_kinase -LRB- RSK -RRB- in a MEK-dependent fashion in renal mIMCD3 cells .
10839461	0	Urethanyl-3-amidinophenylalanine	0,32	factor_Xa	62,71	Urethanyl-3-amidinophenylalanine	factor Xa	null	2159	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Urethanyl-3-amidinophenylalanine derivatives as inhibitors of factor_Xa .
26571421	0	Uric_Acid	9,18	Insulin	45,52	Uric Acid	Insulin	MESH:D014527	3630	Chemical	Gene	START_ENTITY|dep|Resistance Resistance|compound|END_ENTITY	Lowering Uric_Acid With Allopurinol Improves Insulin Resistance and Systemic_Inflammation in Asymptomatic Hyperuricemia .
21352397	0	Uric_acid	0,9	IL-1b	30,35	Uric acid	IL-1b	MESH:D014527	3553	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|compound|END_ENTITY	Uric_acid induces trophoblast IL-1b production via the inflammasome : implications for the pathogenesis of preeclampsia .
19218193	0	Uric_acid	0,9	NALP3	40,45	Uric acid	NALP3	MESH:D014527	216799(Tax:10090)	Chemical	Gene	signal|nsubj|START_ENTITY signal|acl|activating activating|dobj|inflammasome inflammasome|nummod|END_ENTITY	Uric_acid is a danger signal activating NALP3 inflammasome in lung_injury_inflammation and fibrosis .
24925478	0	Uric_acid	0,9	dipeptidyl_peptidase_IV	24,47	Uric acid	dipeptidyl peptidase IV	MESH:D014527	1803	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Uric_acid inhibition of dipeptidyl_peptidase_IV in vitro is dependent on the intracellular formation of triuret .
18945502	0	Uric_acid	0,9	endothelin-1	74,86	Uric acid	endothelin-1	MESH:D014527	24323(Tax:10116)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|kinases kinases|advmod|thereafter thereafter|nmod:npmod|expression expression|amod|END_ENTITY	Uric_acid activates extracellular signal-regulated kinases and thereafter endothelin-1 expression in rat cardiac fibroblasts .
18954524	0	Uric_acid	0,9	endothelin-1	21,33	Uric acid	endothelin-1	MESH:D014527	1906	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Uric_acid stimulates endothelin-1 gene expression associated with NADPH oxidase in human aortic smooth muscle cells .
23112875	0	Uric_acid	0,9	fructokinase	21,33	Uric acid	fructokinase	MESH:D014527	3795	Chemical	Gene	stimulates|amod|START_ENTITY END_ENTITY|nsubj|stimulates	Uric_acid stimulates fructokinase and accelerates fructose metabolism in the development of fatty_liver .
12743010	0	Uric_acid	0,9	monocyte_chemoattractant_protein-1	21,55	Uric acid	monocyte chemoattractant protein-1	MESH:D014527	6347	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|amod|END_ENTITY	Uric_acid stimulates monocyte_chemoattractant_protein-1 production in vascular smooth muscle cells via mitogen-activated protein kinase and cyclooxygenase-2 .
26545879	0	Uridine_Diphosphate	15,34	Macrophage_Inflammatory_Protein-1_Alpha	38,77	Uridine Diphosphate	Macrophage Inflammatory Protein-1 Alpha	MESH:D014530	20302(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|Production Production|compound|END_ENTITY	Enhancement by Uridine_Diphosphate of Macrophage_Inflammatory_Protein-1_Alpha Production in Microglia Derived from Sandhoff Disease Model Mice .
21956191	0	Uridine_adenosine_tetraphosphate	0,32	P2Y	71,74	Uridine adenosine tetraphosphate	P2Y	MESH:C529314	25265(Tax:10116)	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Uridine_adenosine_tetraphosphate activation of the purinergic receptor P2Y enhances in vitro vascular_calcification .
23053265	0	Uridine_diphosphate	0,19	UGT1A1	75,81	Uridine diphosphate	UGT1A1	MESH:D014530	54658	Chemical	Gene	START_ENTITY|dobj|polymorphisms polymorphisms|appos|END_ENTITY	Uridine_diphosphate glucuronosyl transferase 1 family polypeptide A1 gene -LRB- UGT1A1 -RRB- polymorphisms are associated with toxicity and efficacy in irinotecan monotherapy for refractory pancreatic_cancer .
17733646	0	Urine	28,33	Cholecystokinin	0,15	Urine	Cholecystokinin	null	885	Chemical	Gene	Activity|nmod|START_ENTITY Activity|compound|END_ENTITY	Cholecystokinin Activity of Urine .
16346142	0	Ursodeoxycholic_Acid	24,44	M41	88,91	Ursodeoxycholic Acid	M41	MESH:D014580	100506492	Chemical	Gene	Production|nmod|START_ENTITY Production|nmod|END_ENTITY	Microbial Production of Ursodeoxycholic_Acid from Lithocholic_Acid by Fusarium equiseti M41 .
12187295	0	Ursodeoxycholic_Acid	10,30	Ntcp	95,99	Ursodeoxycholic Acid	Ntcp	MESH:D014580	24777(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|END_ENTITY	Effect of Ursodeoxycholic_Acid on the Expression of the Hepatocellular Bile_Acid Transporters -LRB- Ntcp and bsep -RRB- in Rats With Estrogen-Induced Cholestasis .
18444174	0	Ursodeoxycholic_acid	0,20	Cox-2	32,37	Ursodeoxycholic acid	Cox-2	MESH:D014580	5743	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Ursodeoxycholic_acid suppresses Cox-2 expression in colon_cancer : roles of Ras , p38 , and CCAAT/enhancer-binding protein .
14514686	0	Ursodeoxycholic_acid	0,20	E2F-1	31,36	Ursodeoxycholic acid	E2F-1	MESH:D014580	399489(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|compound|END_ENTITY	Ursodeoxycholic_acid modulates E2F-1 and p53 expression through a caspase-independent mechanism in transforming_growth_factor_beta1-induced apoptosis of rat hepatocytes .
15556138	0	Ursodeoxycholic_acid	0,20	endothelin-1	30,42	Ursodeoxycholic acid	endothelin-1	MESH:D014580	1906	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Ursodeoxycholic_acid inhibits endothelin-1 production in human vascular endothelial cells .
22429686	0	Ursodeoxycholic_acid	0,20	sodium-glucose_cotransporter	31,59	Ursodeoxycholic acid	sodium-glucose cotransporter	MESH:D014580	64522(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|amod|END_ENTITY	Ursodeoxycholic_acid decreases sodium-glucose_cotransporter -LRB- SGLT2 -RRB- expression and oxidative stress in the kidney of diabetic rats .
17888421	0	Ursodeoxycholic_acid	0,20	tumor_necrosis_factor-alpha	107,134	Ursodeoxycholic acid	tumor necrosis factor-alpha	MESH:D014580	21926(Tax:10090)	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|inhibition inhibition|nmod|END_ENTITY	Ursodeoxycholic_acid protects concanavalin A-induced mouse liver_injury through inhibition of intrahepatic tumor_necrosis_factor-alpha and macrophage_inflammatory_protein-2 production .
22108347	0	Ursolic_acid	0,12	IL-6	24,28	Ursolic acid	IL-6	MESH:C005466	3569	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	Ursolic_acid suppresses IL-6 induced C-reactive_protein expression in HepG2 and protects HUVECs from injury induced by CRP .
21855333	0	Ursolic_acid	0,12	PPAR-a	18,24	Ursolic acid	PPAR-a	MESH:C005466	5465	Chemical	Gene	agonist|nsubj|START_ENTITY agonist|amod|END_ENTITY	Ursolic_acid is a PPAR-a agonist that regulates hepatic lipid metabolism .
24122993	0	Ursolic_acid	0,12	STAT3	79,84	Ursolic acid	STAT3	MESH:C005466	6774	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	Ursolic_acid inhibits the growth of colon_cancer-initiating cells by targeting STAT3 .
20599915	0	Ursolic_acid	0,12	TLR4	97,101	Ursolic acid	TLR4	MESH:C005466	7099	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|cells cells|nmod|END_ENTITY	Ursolic_acid isolated from Uncaria rhynchophylla activates human dendritic cells via TLR2 and/or TLR4 and induces the production of IFN-gamma by CD4 + na ve T cells .
21070071	0	Ursolic_acid	0,12	allograft_inflammatory_factor-1	21,52	Ursolic acid	allograft inflammatory factor-1	MESH:C005466	199	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Ursolic_acid induces allograft_inflammatory_factor-1 expression via a nitric_oxide-related mechanism and increases neovascularization .
21122803	0	Ursolic_acid	0,12	atrial_natriuretic_peptide	40,66	Ursolic acid	atrial natriuretic peptide	MESH:C005466	100009087(Tax:9986)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|secretion secretion|nmod|END_ENTITY	Ursolic_acid increases the secretion of atrial_natriuretic_peptide in isolated perfused beating rabbit atria .
12792782	0	Ursolic_acid	0,12	caspase-3	39,48	Ursolic acid	caspase-3	MESH:C005466	836	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|amod|END_ENTITY	Ursolic_acid induces apoptosis through caspase-3 activation and cell cycle arrest in HaCat cells .
15583801	0	Ursolic_acid	0,12	caspase-3	57,66	Ursolic acid	caspase-3	MESH:C005466	836	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|pathway pathway|amod|END_ENTITY	Ursolic_acid induces Bax-dependent apoptosis through the caspase-3 pathway in endometrial_cancer SNG-II cells .
10811116	0	Ursolic_acid	0,12	cyclooxygenase-2	22,38	Ursolic acid	cyclooxygenase-2	MESH:C005466	5743	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|transcription transcription|amod|END_ENTITY	Ursolic_acid inhibits cyclooxygenase-2 transcription in human mammary epithelial cells .
21566134	0	Ursolic_acid	0,12	interleukin-17	24,38	Ursolic acid	interleukin-17	MESH:C005466	3605	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|production production|amod|END_ENTITY	Ursolic_acid suppresses interleukin-17 -LRB- IL-17 -RRB- production by selectively antagonizing the function of RORgamma t protein .
23900420	0	Ursolic_acid	0,12	mTORC1	24,30	Ursolic acid	mTORC1	MESH:C005466	382056(Tax:10090)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Ursolic_acid stimulates mTORC1 signaling after resistance exercise in rat skeletal muscle .
24740400	0	Ursolic_acid	0,12	mTORC1	41,47	Ursolic acid	mTORC1	MESH:C005466	382056(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Ursolic_acid inhibits leucine-stimulated mTORC1 signaling by suppressing mTOR localization to lysosome .
16188240	0	Ursolic_acid	0,12	macrophage_migration_inhibitory_factor	37,75	Ursolic acid	macrophage migration inhibitory factor	MESH:C005466	17319(Tax:10090)	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|release release|nmod|END_ENTITY	Ursolic_acid promotes the release of macrophage_migration_inhibitory_factor via ERK2 activation in resting mouse macrophages .
12907607	0	Ursolic_acid	0,12	nuclear_factor-kappaB	22,43	Ursolic acid	nuclear factor-kappaB	MESH:C005466	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	Ursolic_acid inhibits nuclear_factor-kappaB activation induced by carcinogenic agents through suppression of IkappaBalpha kinase and p65 phosphorylation : correlation with down-regulation of cyclooxygenase_2 , matrix_metalloproteinase_9 , and cyclin_D1 .
26468082	0	Uterine	36,43	Androgen_Receptor	74,91	Uterine	Androgen Receptor	null	11835(Tax:10090)	Chemical	Gene	Model|compound|START_ENTITY Model|compound|END_ENTITY	Development and Characterization of Uterine Glandular Epithelium Specific Androgen_Receptor Knockout Mouse Model .
16635211	0	Uterine	0,7	CD56	9,13	Uterine	CD56	null	4684	Chemical	Gene	START_ENTITY|appos|+ +|compound|END_ENTITY	Uterine -LRB- CD56 + -RRB- natural killer cells recruitment : association with decidual reaction rather than embryo implantation .
24746821	0	Uterine	0,7	MED12	25,30	Uterine	MED12	null	9968	Chemical	Gene	mutations|amod|START_ENTITY mutations|compound|END_ENTITY	Uterine leiomyoma-linked MED12 mutations disrupt mediator-associated CDK activity .
25677774	0	Uterine	40,47	Nociceptin	11,21	Uterine	Nociceptin	null	5368	Chemical	Gene	Contraction|compound|START_ENTITY Effects|nmod|Contraction Effects|nmod|END_ENTITY	Effects of Nociceptin and Nocistatin on Uterine Contraction .
1754546	0	Uterine	0,7	calcium-binding_protein	8,31	Uterine	calcium-binding protein	null	1068	Chemical	Gene	START_ENTITY|dobj|activity activity|amod|END_ENTITY	Uterine calcium-binding_protein activity of nonlaying hens and hens laying hard-shelled or shell-less eggs .
9492020	0	Uterine	0,7	epidermal_growth_factor_receptor	42,74	Uterine	epidermal growth factor receptor	null	13649(Tax:10090)	Chemical	Gene	requires|nsubj|START_ENTITY requires|dobj|END_ENTITY	Uterine and vaginal organ growth requires epidermal_growth_factor_receptor signaling from stroma .
6881327	0	Uterine	0,7	lipoprotein_lipase	20,38	Uterine	lipoprotein lipase	null	24539(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|activity activity|amod|END_ENTITY	Uterine and adipose lipoprotein_lipase activity in hormone-treated and pregnant rats .
3084897	0	Uteroglobin	0,11	phospholipase_A2	21,37	Uteroglobin	phospholipase A2	null	151056	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Uteroglobin inhibits phospholipase_A2 activity .
26241178	0	V0162	20,25	M3_muscarinic_acetylcholine_receptors	65,102	V0162	M3 muscarinic acetylcholine receptors	null	1131	Chemical	Gene	Characterization|nmod|START_ENTITY Characterization|appos|antagonist antagonist|nmod|END_ENTITY	Characterization of V0162 , a new long-acting antagonist at human M3_muscarinic_acetylcholine_receptors .
18154688	0	V112220	83,90	TRPV-1	64,70	V112220	TRPV-1	null	100135466(Tax:10141)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	Inhibition of citric_acid - and capsaicin-induced cough by novel TRPV-1 antagonist , V112220 , in guinea-pig .
23185274	0	V1801	19,24	Noxa	127,131	V1801	Noxa	MESH:C580991	5366	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|up-regulation up-regulation|nmod|END_ENTITY	Gefitinib analogue V1801 induces apoptosis of T790M EGFR-harboring lung_cancer cells by up-regulation of the BH-3 only protein Noxa .
16242777	0	VAA-I	179,184	lamin_B1	149,157	VAA-I	lamin B1	null	4001	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Viscum album agglutinin-I -LRB- VAA-I -RRB- induces apoptosis and degradation of cytoskeletal proteins in human leukemia PLB-985 and X-CGD cells via caspases : lamin_B1 is a novel target of VAA-I .
24116867	0	VB-201	0,6	CD14	58,62	VB-201	CD14	MESH:C552500	929	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	VB-201 , an oxidized phospholipid small molecule , inhibits CD14 - and Toll-like_receptor-2-dependent innate cell activation and constrains atherosclerosis .
22562723	5	VB3323	902,908	TLR4	885,889	VB3323	TLR4	null	21898(Tax:10090)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	Using primary cultures from mouse spinal cords , we characterized both the proinflammatory and neurotoxic effects of TLR4 activation with lipopolysaccharide -LRB- activation of microglial cells , release of proinflammatory cytokines and motor neuron_death -RRB- and the protective effects of a cyanobacteria-derived TLR4 antagonist -LRB- VB3323 -RRB- .
23934411	0	VE-821	54,60	ATR	14,17	VE-821	ATR	MESH:C560580	545	Chemical	Gene	results|compound|START_ENTITY kinase|dobj|results kinase|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of ATR kinase with the selective inhibitor VE-821 results in radiosensitization of cells of promyelocytic leukaemia -LRB- HL-60 -RRB- .
25003641	0	VE-821	74,80	ATR	52,55	VE-821	ATR	MESH:C560580	545	Chemical	Gene	inhibitor|appos|START_ENTITY kinase|dobj|inhibitor kinase|nsubj|Radiosensitization Radiosensitization|nmod|cells cells|nmod|END_ENTITY	Radiosensitization of human leukemic HL-60 cells by ATR kinase inhibitor -LRB- VE-821 -RRB- : phosphoproteomic analysis .
26286029	0	VE-821	0,6	ATR	11,14	VE-821	ATR	MESH:C560580	545	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	VE-821 , an ATR inhibitor , causes radiosensitization in human tumor cells irradiated with high LET radiation .
9395496	0	VEGF165	154,161	VEGF	50,54	VEGF165	VEGF	MESH:C467484	7422	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of vascular_endothelial_growth_factor -LRB- VEGF -RRB- - induced endothelial cell proliferation by a peptide corresponding to the exon 7-encoded domain of VEGF165 .
17028197	0	VEGF165	96,103	VEGFR-2	115,122	VEGF165	VEGFR-2	MESH:C467484	3791	Chemical	Gene	binding|nsubj|START_ENTITY binding|nmod|END_ENTITY	Low molecular weight fucoidan increases VEGF165-induced endothelial cell migration by enhancing VEGF165 binding to VEGFR-2 and NRP1 .
16423422	0	VEGF165	25,32	neuropilin-1	44,56	VEGF165	neuropilin-1	MESH:C467484	8829	Chemical	Gene	peptide|nmod|START_ENTITY binding|nsubj|peptide binding|nmod|mediates mediates|amod|END_ENTITY	A peptide competing with VEGF165 binding on neuropilin-1 mediates targeting of a chlorin-type photosensitizer and potentiates its photodynamic activity in human endothelial cells .
18272814	0	VEGF165	109,116	neuropilin-1	51,63	VEGF165	neuropilin-1	MESH:C467484	18186(Tax:10090)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Sulfated polysaccharides identified as inducers of neuropilin-1 internalization and functional inhibition of VEGF165 and semaphorin3A .
19270265	0	VEGF165	68,75	neuropilin-1	21,33	VEGF165	neuropilin-1	MESH:C467484	8829	Chemical	Gene	mimicry|nmod|START_ENTITY END_ENTITY|nmod|mimicry	HTLV-1 uses HSPG and neuropilin-1 for entry by molecular mimicry of VEGF165 .
11862610	0	VEGF165	56,63	vascular_endothelial_growth_factor	20,54	VEGF165	vascular endothelial growth factor	MESH:C467484	7422	Chemical	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of human vascular_endothelial_growth_factor -LRB- VEGF165 -RRB- in Pichia_pastoris and its biological activity .
12354175	0	VEGF165	108,115	vascular_endothelial_growth_factor	72,106	VEGF165	vascular endothelial growth factor	MESH:C467484	397157(Tax:9823)	Chemical	Gene	application|appos|START_ENTITY application|nmod|amounts amounts|nmod|encoding encoding|nmod|END_ENTITY	Local perivascular application of low amounts of a plasmid encoding for vascular_endothelial_growth_factor -LRB- VEGF165 -RRB- is efficient for therapeutic angiogenesis in pigs .
16289914	0	VEGF165	77,84	vascular_endothelial_growth_factor	41,75	VEGF165	vascular endothelial growth factor	MESH:C467484	7422	Chemical	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and characterization of human vascular_endothelial_growth_factor -LRB- VEGF165 -RRB- in insect cells .
16468311	0	VEGF165	122,129	vascular_endothelial_growth_factor	24,58	VEGF165	vascular endothelial growth factor	MESH:C467484	7422	Chemical	Gene	cDNA|compound|START_ENTITY line|nmod|cDNA expression|nmod|line expression|amod|END_ENTITY	-LSB- Targeted inhibition of vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in human osteosarcoma cell line by antisense VEGF165 cDNA promoted by hypoxia reaction element -RSB- .
18415983	0	VEGF165	95,102	vascular_endothelial_growth_factor	55,89	VEGF165	vascular endothelial growth factor	MESH:C467484	7422	Chemical	Gene	165|appos|START_ENTITY 165|compound|END_ENTITY	Identification of a neutralizing scFv binding to human vascular_endothelial_growth_factor 165 -LRB- VEGF165 -RRB- using a phage display antibody library .
21303748	0	VEGF165	58,65	vascular_endothelial_growth_factor	18,52	VEGF165	vascular endothelial growth factor	MESH:C467484	7422	Chemical	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of vascular_endothelial_growth_factor 165 -LRB- VEGF165 -RRB- protects cardiomyocytes against doxorubicin-induced apoptosis .
8621443	0	VEGF165	103,110	vascular_endothelial_growth_factor	26,60	VEGF165	vascular endothelial growth factor	MESH:C467484	7422	Chemical	Gene	receptors|dobj|START_ENTITY receptors|nsubj|Characterization Characterization|nmod|END_ENTITY	Characterization of novel vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptors on tumor cells that bind VEGF165 via its exon 7-encoded domain .
9395496	0	VEGF165	154,161	vascular_endothelial_growth_factor	14,48	VEGF165	vascular endothelial growth factor	MESH:C467484	7422	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of vascular_endothelial_growth_factor -LRB- VEGF -RRB- - induced endothelial cell proliferation by a peptide corresponding to the exon 7-encoded domain of VEGF165 .
24676905	0	VER-155008	0,10	HSP70	42,47	VER-155008	HSP70	MESH:C550733	3308	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	VER-155008 , a small molecule inhibitor of HSP70 with potent anti-cancer activity on lung_cancer cell lines .
15064856	0	VGA1102	63,70	VEGF	29,33	VGA1102	VEGF	MESH:C487873	22339(Tax:10090)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	A novel low molecular weight VEGF receptor-binding antagonist , VGA1102 , inhibits the function of VEGF and in vivo tumor growth .
15064856	0	VGA1102	63,70	VEGF	97,101	VGA1102	VEGF	MESH:C487873	22339(Tax:10090)	Chemical	Gene	antagonist|appos|START_ENTITY inhibits|nsubj|antagonist inhibits|nmod|END_ENTITY	A novel low molecular weight VEGF receptor-binding antagonist , VGA1102 , inhibits the function of VEGF and in vivo tumor growth .
15517909	0	VGA1155	0,7	VEGF	39,43	VGA1155	VEGF	MESH:C487956	7422	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|nmod|END_ENTITY	VGA1155 , a novel binding antagonist of VEGF , inhibits angiogenesis in vitro and in vivo .
18204296	0	VGA1155	36,43	VEGF	10,14	VGA1155	VEGF	MESH:C487956	83785(Tax:10116)	Chemical	Gene	Effect|appos|START_ENTITY Effect|nmod|antagonist antagonist|compound|END_ENTITY	Effect of VEGF receptor antagonist -LRB- VGA1155 -RRB- on brain_edema in the rat cold injury model .
21063140	0	VGA1155	36,43	VEGF	10,14	VGA1155	VEGF	MESH:C487956	83785(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	The novel VEGF receptor antagonist , VGA1155 , reduces edema , decreases_infarct and improves neurological function after stroke in rats .
17619118	0	VIP-DAP	88,95	VIP	53,56	VIP-DAP	VIP	null	7432	Chemical	Gene	peptide|appos|START_ENTITY peptide|appos|END_ENTITY	Experimental study on vasoactive intestinal peptide -LRB- VIP -RRB- and its diaminopropane bound -LRB- VIP-DAP -RRB- analog in solution .
19559015	0	VM-26	47,52	LRRFIP1	20,27	VM-26	LRRFIP1	MESH:D013713	9208	Chemical	Gene	resistance|compound|START_ENTITY END_ENTITY|nmod|resistance	MicroRNA-21 targets LRRFIP1 and contributes to VM-26 resistance in glioblastoma multiforme .
9024781	0	VM26	62,66	Jun	0,3	VM26	Jun	MESH:D013713	3725	Chemical	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	Jun and JNK kinase are activated in thymocytes in response to VM26 and radiation but not glucocorticoids .
15448746	0	VNP20047	46,54	F10	62,65	VNP20047	F10	null	14058(Tax:10090)	Chemical	Gene	activity|nmod|START_ENTITY activity|appos|END_ENTITY	Antitumour activity of Salmonella_typhimurium VNP20047 in B16 -LRB- F10 -RRB- murine melanoma model .
14508237	0	VOA	29,32	CGRP	106,110	VOA	CGRP	null	24241(Tax:10116)	Chemical	Gene	relaxation|compound|START_ENTITY relaxation|dep|involvement involvement|nmod|END_ENTITY	A novel capsaicin derivative VOA induced relaxation in rat mesenteric and aortic arteries : involvement of CGRP , NO , cGMP , and endothelium-dependent activities .
12475412	0	VP22-TK	83,90	MUC1	101,105	VP22-TK	MUC1	null	4582	Chemical	Gene	system|compound|START_ENTITY system|nmod|END_ENTITY	-LSB- Anti-tumor effect of lentivirus-mediated MUCI antibody-targeted gene therapy with VP22-TK system on MUC1 -LRB- + -RRB- human ovarian_cancer transplanted intraperitoneally in nude_mice -RSB- .
21959976	0	VPA	0,3	HDAC2	68,73	VPA	HDAC2	CHEBI:39867	3066	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	VPA inhibits breast_cancer cell migration by specifically targeting HDAC2 and down-regulating Survivin .
24390319	0	VPA	0,3	HIF-1a	80,86	VPA	HIF-1a	CHEBI:39867	3091	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	VPA inhibits renal_cancer cell migration by targeting HDAC2 and down-regulating HIF-1a .
17392393	4	VPA	799,802	MDR1	806,810	VPA	MDR1	CHEBI:39867	5243	Chemical	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	By contrast , a significant effect of VPA on MDR1 promoter activation was observed only in CAR-cotransfected HepG2 cells .
17845807	0	VRT-018858	46,56	caspase-1	25,34	VRT-018858	caspase-1	MESH:C525665	25166(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	A selective , non-peptide caspase-1 inhibitor , VRT-018858 , markedly reduces brain_damage induced by transient ischemia in the rat .
17363488	0	VRX0466617	45,55	Chk2	115,119	VRX0466617	Chk2	MESH:C520468	11200	Chemical	Gene	characterization|nmod|START_ENTITY characterization|appos|inhibitor inhibitor|nmod|END_ENTITY	Biochemical and cellular characterization of VRX0466617 , a novel and selective inhibitor for the checkpoint kinase Chk2 .
26334219	0	VS-6063	19,26	focal_adhesion_kinase	48,69	VS-6063	focal adhesion kinase	null	5747	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	A phase I study of VS-6063 , a second-generation focal_adhesion_kinase inhibitor , in patients with advanced solid tumors .
25224009	0	VT-1161	23,30	CYP51	80,85	VT-1161	CYP51	null	1595	Chemical	Gene	Inhibitor|nsubj|START_ENTITY Inhibitor|nmod|END_ENTITY	The Clinical Candidate VT-1161 is a Highly Potent Inhibitor of Candida_albicans CYP51 but Fails to Bind the Human Enzyme .
24900262	0	VTP-27999	13,22	Renin	39,44	VTP-27999	Renin	null	5972	Chemical	Gene	Discovery|nmod|START_ENTITY Discovery|appos|Inhibitor Inhibitor|compound|END_ENTITY	Discovery of VTP-27999 , an Alkyl_Amine Renin Inhibitor with Potential for Clinical Utility .
27042301	0	VTX-1463	0,8	TLR-8	18,23	VTX-1463	TLR-8	null	100684828	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	VTX-1463 , a novel TLR-8 agonist , attenuates nasal congestion after ragweed challenge in sensitized beagle_dogs .
21548830	0	VTX-1463	0,8	TLR8	18,22	VTX-1463	TLR8	null	51311	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	VTX-1463 , a novel TLR8 agonist for the treatment of allergic_rhinitis .
26928328	0	VTX-2337	84,92	TLR8	70,74	VTX-2337	TLR8	MESH:C573973	51311	Chemical	Gene	Activity|dep|START_ENTITY Activity|compound|END_ENTITY	Coordinated Activation of Toll-Like_Receptor8 -LRB- TLR8 -RRB- and NLRP3 by the TLR8 Agonist , VTX-2337 , Ignites Tumoricidal Natural Killer Cell Activity .
25784602	0	VU0410120	11,20	GlyT1	30,35	VU0410120	GlyT1	null	14664(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effects of VU0410120 , a novel GlyT1 inhibitor , on measures of sociability , cognition and stereotypic behaviors in a mouse model of autism .
16474185	0	VULM1457	19,27	ACAT	4,8	VULM1457	ACAT	MESH:C505646	6646	Chemical	Gene	START_ENTITY|nsubj|inhibitor inhibitor|compound|END_ENTITY	The ACAT inhibitor VULM1457 significantly reduced production and secretion of adrenomedullin -LRB- AM -RRB- and down-regulated AM receptors on human hepatoblastic cells .
18281742	0	VULM_1457	10,19	ACAT	24,28	VULM 1457	ACAT	MESH:C505646	6646	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effect of VULM_1457 , an ACAT inhibitor , on serum lipid levels and on real time red blood cell flow in diabetic and non-diabetic hamsters fed high cholesterol-lipid diet .
22221201	0	VX-322	0,6	receptor_tyrosine_kinase	21,45	VX-322	receptor tyrosine kinase	MESH:C568953	5979	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	VX-322 : a novel dual receptor_tyrosine_kinase inhibitor for the treatment of acute_myelogenous_leukemia .
25762693	0	VX-509	0,6	JAK3	49,53	VX-509	JAK3	null	3718	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|appos|END_ENTITY	VX-509 is a potent and selective Janus_kinase_3 -LRB- JAK3 -RRB- inhibitor that attenuates inflammation in animal models of autoimmune_disease .
25762693	0	VX-509	0,6	Janus_kinase_3	33,47	VX-509	Janus kinase 3	null	3718	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|compound|END_ENTITY	VX-509 is a potent and selective Janus_kinase_3 -LRB- JAK3 -RRB- inhibitor that attenuates inflammation in animal models of autoimmune_disease .
18032922	0	VX-680	0,6	Aurora_A	16,24	VX-680	Aurora A	MESH:C484810	6790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	VX-680 inhibits Aurora_A and Aurora_B kinase activity in human cells .
19404957	0	VX-702	42,48	p38	58,61	VX-702	p38	MESH:C517771	1432	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Efficacy , pharmacodynamics , and safety of VX-702 , a novel p38 MAPK inhibitor , in rheumatoid_arthritis : results of two randomized , double-blind , placebo-controlled clinical studies .
9073310	0	VX-710	52,58	MRP	199,202	VX-710	MRP	MESH:C106077	4363	Chemical	Gene	effects|nmod|START_ENTITY effects|acl|expressing expressing|dobj|END_ENTITY	Chemosensitization and drug accumulation effects of VX-710 , verapamil , cyclosporin_A , MS-209 and GF120918 in multidrug resistant HL60/ADR cells expressing the multidrug resistance-associated protein MRP .
21306143	0	VX680	0,5	Aurora_A	17,25	VX680	Aurora A	MESH:C484810	6790	Chemical	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	VX680 binding in Aurora_A : - interactions involving the conserved aromatic_amino_acid of the flexible glycine-rich loop .
26742834	0	VX765	53,58	caspase-1	33,42	VX765	caspase-1	MESH:C520022	12362(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Effects and mechanisms of potent caspase-1 inhibitor VX765 treatment on collagen-induced_arthritis in mice .
19674131	0	VacA	20,24	NF-kappaB	35,44	VacA	NF-kappaB	null	4790	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Helicobacter_pylori VacA activates NF-kappaB in T cells via the classical but not alternative pathway .
25074447	0	Val	9,12	BDNF	4,8	Val	BDNF	CHEBI:16414	627	Chemical	Gene	Met|compound|START_ENTITY Met|compound|END_ENTITY	The BDNF Val -LRB- 66 -RRB- Met polymorphism is associated with escitalopram response in depressed patients .
22593075	0	Val	34,37	Brain-derived_neurotrophic_factor	0,33	Val	Brain-derived neurotrophic factor	CHEBI:16414	627	Chemical	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	Brain-derived_neurotrophic_factor Val Met polymorphism affects resting regional cerebral blood flow and functional connectivity differentially in women versus men .
15465976	0	Val	21,24	COMT	15,19	Val	COMT	CHEBI:16414	1312	Chemical	Gene	Interaction|dep|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of COMT -LRB- Val -LRB- 108/158 -RRB- Met -RRB- genotype and olanzapine treatment on prefrontal cortical function in patients with schizophrenia .
18201871	0	Val	125,128	COMT	120,124	Val	COMT	CHEBI:16414	1312	Chemical	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	Personality in relation to genetic liability for schizophrenia and bipolar_disorder : differential associations with the COMT Val 108/158 Met polymorphism .
22049425	3	Val	546,549	COMT	495,499	Val	DRD2	CHEBI:16414	1813	Chemical	Gene	low|appos|START_ENTITY associated|nmod|low polymorphism|acl|associated polymorphism|appos|END_ENTITY	Male human participants -LRB- n = 169 -RRB- were genotyped for the catechol-O-methyltransferase -LRB- COMT -RRB- Val158Met polymorphism , associated with low -LRB- Val -RRB- and medium -LRB- Met -RRB- PFC DA levels .
22364739	0	Val	5,8	COMT	0,4	Val	COMT	CHEBI:16414	1312	Chemical	Gene	Met|compound|START_ENTITY Met|compound|END_ENTITY	COMT Val -LRB- 158 -RRB- Met genotype determines the direction of cognitive effects produced by catechol-O-methyltransferase inhibition .
22740151	0	Val	15,18	COMT	10,14	Val	COMT	CHEBI:16414	1312	Chemical	Gene	Met|compound|START_ENTITY Met|compound|END_ENTITY	Impact of COMT Val 108/158 Met and DRD2 Taq1B gene polymorphisms on vulnerability to cigarette smoking of Thai males .
23421762	0	Val	50,53	COMT	0,4	Val	COMT	CHEBI:16414	1312	Chemical	Gene	allele|compound|START_ENTITY associated|nsubjpass|allele allele|parataxis|associated allele|nsubj|Met Met|compound|END_ENTITY	COMT rs4680 Met is not always the ` smart allele ' : Val allele is associated with better working memory and larger hippocampal volume in healthy Chinese .
24030137	0	Val	31,34	COMT	26,30	Val	COMT	CHEBI:16414	1312	Chemical	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	Cognitive control and the COMT Val Met polymorphism : genetic modulation of videogame training and transfer to task-switching efficiency .
24410746	0	Val	22,25	COMT	17,21	Val	COMT	CHEBI:16414	1312	Chemical	Gene	Met|compound|START_ENTITY Met|compound|END_ENTITY	Contributions of COMT Val Met to cognitive stability and flexibility in infancy .
25071511	0	Val	5,8	COMT	0,4	Val	COMT	CHEBI:16414	1312	Chemical	Gene	Met|compound|START_ENTITY Met|compound|END_ENTITY	COMT Val -LRB- 158 -RRB- Met genotypes differentially influence subgenual cingulate functional connectivity in healthy females .
25161818	0	Val	22,25	COMT	17,21	Val	COMT	CHEBI:16414	1312	Chemical	Gene	genotype|compound|START_ENTITY genotype|compound|END_ENTITY	The influence of COMT Val Met genotype on the character dimension cooperativeness in healthy females .
25682348	0	Val	26,29	COMT	21,25	Val	COMT	CHEBI:16414	1312	Chemical	Gene	Met|compound|START_ENTITY Met|compound|END_ENTITY	Modulating effect of COMT Val -LRB- 158 -RRB- Met polymorphism on interference resolution during a working memory task .
26879624	0	Val	25,28	COMT	20,24	Val	COMT	CHEBI:16414	1312	Chemical	Gene	Met|compound|START_ENTITY Met|compound|END_ENTITY	Interaction between COMT Val -LRB- 158 -RRB- Met polymorphism and childhood adversity affects reward processing in adulthood .
26973509	0	Val	44,47	COMT	39,43	Val	COMT	CHEBI:16414	1312	Chemical	Gene	Met|compound|START_ENTITY Met|compound|END_ENTITY	Pulse Pressure Magnifies the Effect of COMT Val -LRB- 158 -RRB- Met on 15 Years Episodic Memory Trajectories .
18288203	0	Val	55,58	GSTP1	49,54	Val	GSTP1	CHEBI:16414	2950	Chemical	Gene	effect|dep|START_ENTITY effect|nmod|END_ENTITY	A protective effect of glutathione-S-transferase GSTP1 * Val -LRB- 105 -RRB- against polymorphic_light_eruption .
10332959	3	Val	902,905	MTHFR	918,923	Val	MTHFR	CHEBI:16414	4524	Chemical	Gene	mutation|compound|START_ENTITY mutation|nmod|END_ENTITY	We were unable to demonstrate an association using a previously described Ala -- > Val mutation in MTHFR and the majority of our NTD populations .
21733227	0	Val	61,64	brain-derived_neurotrophic_factor	20,53	Val	brain-derived neurotrophic factor	CHEBI:16414	627	Chemical	Gene	polymorphism|compound|START_ENTITY polymorphism|amod|END_ENTITY	Val/Val genotype of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- Val Met polymorphism is associated with a better response to OROS-MPH in Korean ADHD children .
23357445	0	Val	93,96	brain-derived_neurotrophic_factor	59,92	Val	brain-derived neurotrophic factor	CHEBI:16414	627	Chemical	Gene	Met|compound|START_ENTITY Met|compound|END_ENTITY	Gray matter volume in adolescent anxiety : an impact of the brain-derived_neurotrophic_factor Val -LRB- 66 -RRB- Met polymorphism ?
26751724	0	Val	66,69	brain-derived_neurotrophic_factor	105,138	Val	brain-derived neurotrophic factor	CHEBI:16414	627	Chemical	Gene	allele|compound|START_ENTITY associated|nmod|allele associated|nmod|gene gene|amod|END_ENTITY	Reduced severity of posttraumatic_stress_disorder associated with Val allele of Val66Met polymorphism at brain-derived_neurotrophic_factor gene among Chinese adolescents after Wenchuan earthquake .
11721009	0	Val	43,46	p21	57,60	Val	p21	CHEBI:16414	644914	Chemical	Gene	mutant|compound|START_ENTITY mutant|nmod|END_ENTITY	Molecular dynamics simulations of Gly-12 -- > Val mutant of p21 -LRB- ras -RRB- : dynamic inhibition mechanism .
7911198	0	Val	9,12	superoxide_dismutase-1	37,59	Val	superoxide dismutase-1	CHEBI:16414	6647	Chemical	Gene	mutation|compound|START_ENTITY mutation|nmod|gene gene|amod|END_ENTITY	Leu106 -- > Val -LRB- CTC -- > GTC -RRB- mutation of superoxide_dismutase-1 gene in patient with familial amyotrophic lateral_sclerosis in Japan .
2619739	0	Val-Tyr-Ile-NH2	58,73	angiotensin_II	25,39	Val-Tyr-Ile-NH2	angiotensin II	null	24179(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Psychotropic activity of angiotensin_II and its fragments Val-Tyr-Ile-NH2 and Val-Tyr-Ile-His-NH2 .
23517091	0	Valdecoxib	0,10	COX-2	36,41	Valdecoxib	COX-2	MESH:C406224	5743	Chemical	Gene	START_ENTITY|dep|rise rise|nmod|inhibitor inhibitor|compound|END_ENTITY	Valdecoxib : the rise and fall of a COX-2 inhibitor .
11981510	0	Valdecoxib	0,10	cox-2	27,32	Valdecoxib	cox-2	MESH:C406224	4513	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Valdecoxib -LRB- Bextra -RRB- -- a new cox-2 inhibitor .
15494548	0	Valdecoxib	0,10	cyclooxygenase-2	26,42	Valdecoxib	cyclooxygenase-2	MESH:C406224	5743	Chemical	Gene	START_ENTITY|dep|assessment assessment|nmod|potency potency|amod|END_ENTITY	Valdecoxib : assessment of cyclooxygenase-2 potency and selectivity .
1257579	0	Valinomycin	0,11	cardiac_muscle	53,67	Valinomycin	cardiac muscle	MESH:D014634	395534(Tax:9031)	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	Valinomycin inhibition of the inward slow current of cardiac_muscle .
21241777	0	Valproate	0,9	CHOP	18,22	Valproate	CHOP	MESH:D014635	29467(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|levels levels|compound|END_ENTITY	Valproate reduces CHOP levels and preserves oligodendrocytes and axons after spinal_cord_injury .
23073524	0	Valproate	0,9	ERK	20,23	Valproate	ERK	MESH:D014635	5594	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Valproate activates ERK signaling pathway in primary human hepatocytes .
11106869	0	Valproate	0,9	N-cadherin	19,29	Valproate	N-cadherin	MESH:D014635	378519(Tax:8355)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|amod|END_ENTITY	Valproate enhances N-cadherin production in Xenopus embryos .
27013471	0	Valproate	49,58	Scn3a	29,34	Valproate	Scn3a	MESH:D014635	20269(Tax:10090)	Chemical	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	Epigenetic Downregulation of Scn3a Expression by Valproate : a Possible Role in Its Anticonvulsant Activity .
19125190	0	Valproate	0,9	WFS1	38,42	Valproate	WFS1	MESH:D014635	7466	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Valproate , a mood stabilizer , induces WFS1 expression and modulates its interaction with ER stress protein GRP94 .
16985053	0	Valproate	0,9	histone_deacetylase_2	24,45	Valproate	histone deacetylase 2	MESH:D014635	3066	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Valproate inhibition of histone_deacetylase_2 affects differentiation and decreases proliferation of endometrial_stromal_sarcoma cells .
24265868	0	Valproic_Acid	0,13	JNK	55,58	Valproic Acid	JNK	MESH:D014635	116554(Tax:10116)	Chemical	Gene	Regulates|nsubj|START_ENTITY Regulates|nmod|Pathway Pathway|compound|END_ENTITY	Valproic_Acid Regulates a-Synuclein Expression through JNK Pathway in Rat Primary Astrocytes .
25613019	0	Valproic_Acid	0,13	MTNR1A	25,31	Valproic Acid	MTNR1A	MESH:D014635	4543	Chemical	Gene	Intracellular|compound|START_ENTITY Intracellular|compound|END_ENTITY	Valproic_Acid Influences MTNR1A Intracellular Trafficking and Signaling in a b-Arrestin_2-Dependent Manner .
18955571	0	Valproic_acid	0,13	Abeta	23,28	Valproic acid	Abeta	MESH:D014635	11820(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	Valproic_acid inhibits Abeta production , neuritic_plaque formation , and behavioral_deficits in Alzheimer 's _ disease mouse models .
23555843	0	Valproic_acid	0,13	CD40L	46,51	Valproic acid	CD40L	MESH:D014635	959	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|nmod|END_ENTITY	Valproic_acid inhibits the release of soluble CD40L induced by non-nucleoside reverse transcriptase inhibitors in human_immunodeficiency_virus_infected individuals .
9858943	0	Valproic_acid	0,13	CD44	63,67	Valproic acid	CD44	MESH:D014635	960	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Valproic_acid inhibits proliferation and changes expression of CD44 and CD56 of malignant_glioma cells in vitro .
17392393	0	Valproic_acid	0,13	CYP3A4	22,28	Valproic acid	CYP3A4	MESH:D014635	1576	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Valproic_acid induces CYP3A4 and MDR1 gene expression by activation of constitutive_androstane_receptor and pregnane_X_receptor pathways .
24200999	0	Valproic_acid	0,13	HDAC7	60,65	Valproic acid	HDAC7	MESH:D014635	51564	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|compound|END_ENTITY	Valproic_acid , but not levetiracetam , selectively decreases HDAC7 and HDAC2 expression in human ovarian_cancer cells .
22701311	0	Valproic_acid	0,13	MGMT	46,50	Valproic acid	MGMT	MESH:D014635	4255	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|nmod|END_ENTITY	Valproic_acid downregulates the expression of MGMT and sensitizes temozolomide-resistant glioma cells .
24552656	0	Valproic_acid	0,13	MKP-1	84,89	Valproic acid	MKP-1	MESH:D014635	19252(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|nmod|END_ENTITY	Valproic_acid suppresses lipopolysaccharide-induced cyclooxygenase-2 expression via MKP-1 in murine brain microvascular endothelial cells .
18520232	0	Valproic_acid	0,13	Notch1	24,30	Valproic acid	Notch1	MESH:D014635	4851	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Valproic_acid activates Notch1 signaling and induces apoptosis in medullary_thyroid_cancer cells .
18570928	0	Valproic_acid	0,13	Notch1	22,28	Valproic acid	Notch1	MESH:D014635	4851	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Valproic_acid induces Notch1 signaling in small_cell_lung_cancer cells .
23435724	0	Valproic_acid	0,13	Notch1	83,89	Valproic acid	Notch1	MESH:D014635	4851	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|progression progression|nmod|END_ENTITY	Valproic_acid suppresses cervical_cancer tumor progression possibly via activating Notch1 signaling and enhances receptor-targeted cancer chemotherapeutic via activating somatostatin_receptor_type_II .
20564199	0	Valproic_acid	0,13	Oct4	23,27	Valproic acid	Oct4	MESH:D014635	100846986	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|amod|END_ENTITY	Valproic_acid enhances Oct4 promoter activity in myogenic cells .
24361750	0	Valproic_acid	0,13	Oct4	23,27	Valproic acid	Oct4	MESH:D014635	5460	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|amod|END_ENTITY	Valproic_acid enhances Oct4 promoter activity through PI3K/Akt/mTOR pathway activated nuclear receptors .
17043155	0	Valproic_acid	0,13	P-glycoprotein	37,51	Valproic acid	P-glycoprotein	MESH:D014635	287115(Tax:10116)	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Valproic_acid is not a substrate for P-glycoprotein or multidrug_resistance_proteins_1_and_2 in a number of in vitro and in vivo transport assays .
14595654	0	Valproic_acid	0,13	SMN	24,27	Valproic acid	SMN	MESH:D014635	6606	Chemical	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	Valproic_acid increases SMN levels in spinal_muscular_atrophy patient cells .
21561730	0	Valproic_acid	0,13	SMN2	24,28	Valproic acid	SMN2	MESH:D014635	6607	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Valproic_acid increases SMN2 expression and modulates SF2/ASF and hnRNPA1 expression in SMA fibroblast cell lines .
15857691	0	Valproic_acid	0,13	c-fos	63,68	Valproic acid	c-fos	MESH:D014635	314322(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	Valproic_acid , but not lamotrigine , suppresses seizure-induced c-fos and c-Jun mRNA expression .
20307625	0	Valproic_acid	0,13	clusterin	25,34	Valproic acid	clusterin	MESH:D014635	1191	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Valproic_acid stimulates clusterin expression in human astrocytes : Implications for Alzheimer 's _ disease .
15644987	0	Valproic_acid	0,13	corticotropin-releasing_factor	23,53	Valproic acid	corticotropin-releasing factor	MESH:D014635	81648(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|synthesis synthesis|amod|END_ENTITY	Valproic_acid inhibits corticotropin-releasing_factor synthesis and release from the rat hypothalamus in vitro : evidence for the involvement of GABAergic neurotransmission .
23349020	0	Valproic_acid	0,13	cyclin_D2	74,83	Valproic acid	cyclin D2	MESH:D014635	12444(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Valproic_acid inhibits the proliferation of cancer cells by re-expressing cyclin_D2 .
24552656	0	Valproic_acid	0,13	cyclooxygenase-2	52,68	Valproic acid	cyclooxygenase-2	MESH:D014635	19225(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Valproic_acid suppresses lipopolysaccharide-induced cyclooxygenase-2 expression via MKP-1 in murine brain microvascular endothelial cells .
19765194	0	Valproic_acid	0,13	heat-shock_protein_70	33,54	Valproic acid	heat-shock protein 70	MESH:D014635	266759(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Valproic_acid induces functional heat-shock_protein_70 via Class I histone deacetylase inhibition in cortical neurons : a potential role of Sp1 acetylation .
17088416	0	Valproic_acid	0,13	histone_deacetylase	17,36	Valproic acid	histone deacetylase	MESH:D014635	9734	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Valproic_acid , a histone_deacetylase inhibitor , enhances sensitivity to doxorubicin in anaplastic_thyroid_cancer cells .
17850978	0	Valproic_acid	0,13	histone_deacetylase	24,43	Valproic acid	histone deacetylase	MESH:D014635	9734	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Valproic_acid and other histone_deacetylase inhibitors induce microglial apoptosis and attenuate lipopolysaccharide-induced dopaminergic neurotoxicity .
21411522	0	Valproic_acid	0,13	histone_deacetylase	48,67	Valproic acid	histone deacetylase	MESH:D014635	9734	Chemical	Gene	antagonizes|nsubj|START_ENTITY antagonizes|dobj|capacity capacity|nmod|inhibitors inhibitors|compound|END_ENTITY	Valproic_acid antagonizes the capacity of other histone_deacetylase inhibitors to activate the Epstein-barr_virus lytic cycle .
12948616	0	Valproic_acid	0,13	insulin	35,42	Valproic acid	insulin	MESH:D014635	3630	Chemical	Gene	modulates|amod|START_ENTITY modulates|dep|secretion secretion|compound|END_ENTITY	Valproic_acid modulates islet cell insulin secretion : a possible mechanism of weight_gain in epilepsy patients .
15331576	0	Valproic_acid	0,13	leptin	23,29	Valproic acid	leptin	MESH:D014635	3952	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|compound|END_ENTITY	Valproic_acid inhibits leptin secretion and reduces leptin messenger ribonucleic acid levels in adipocytes .
18615588	0	Valproic_acid	0,13	methylenetetrahydrofolate_reductase	38,73	Valproic acid	methylenetetrahydrofolate reductase	MESH:D014635	17769(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Valproic_acid increases expression of methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- and induces lower teratogenicity in MTHFR_deficiency .
21775495	0	Valproic_acid	0,13	monoamine_oxidase_A	22,41	Valproic acid	monoamine oxidase A	MESH:D014635	4128	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Valproic_acid induces monoamine_oxidase_A via Akt/forkhead _ box_O1 activation .
17534580	0	Valproic_acid	0,13	p21	22,25	Valproic acid	p21	MESH:D014635	1026	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Valproic_acid induces p21 and topoisomerase-II -LRB- alpha/beta -RRB- expression and synergistically enhances etoposide cytotoxicity in human glioblastoma cell lines .
18853116	5	Valsartan	933,942	Ang_II	948,954	Valsartan	Ang II	MESH:C081489	24179(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	RESULTS : STS could inhibit cardiocyte hypertrophy , increase the protein synthesis rate and enhance proto-oncogene_c-fos mRNA expression in cardiocytes induced by Ang_II -LRB- P < 0.01 -RRB- , with an effect similar to that of Valsartan , the Ang_II receptor antagonist .
26995372	0	Valsartan	151,160	Angiotensin_II	10,24	Valsartan	Angiotensin II	MESH:C081489	183	Chemical	Gene	Randomized|dep|START_ENTITY Effect|dep|Randomized Effect|nmod|Blockade Blockade|compound|END_ENTITY	Effect of Angiotensin_II Type I Receptor Blockade with Valsartan on Carotid Artery_Atherosclerosis : A Double Blind Randomized Clinical Trial Comparing Valsartan and Placebo -LRB- EFFERVESCENT -RRB- .
26995372	0	Valsartan	55,64	Angiotensin_II	10,24	Valsartan	Angiotensin II	MESH:C081489	183	Chemical	Gene	Blockade|nmod|START_ENTITY Blockade|compound|END_ENTITY	Effect of Angiotensin_II Type I Receptor Blockade with Valsartan on Carotid Artery_Atherosclerosis : A Double Blind Randomized Clinical Trial Comparing Valsartan and Placebo -LRB- EFFERVESCENT -RRB- .
25014676	0	Valsartan	0,9	HO-1	98,102	Valsartan	HO-1	MESH:C081489	24451(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|nmod|END_ENTITY	Valsartan decreases neointimal hyperplasia in balloon-injured rat aortic arteries by upregulating HO-1 and inhibiting angiotensin_II_type_1_receptor .
26882812	0	Valsartan	15,24	Irisin	57,63	Valsartan	Irisin	MESH:C081489	252995	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	The Effects of Valsartan and Amlodipine on the Levels of Irisin , Adropin , and Perilipin .
20233535	0	Valsartan	0,9	adiponectin	32,43	Valsartan	adiponectin	MESH:C081489	9370	Chemical	Gene	increases|nsubj|START_ENTITY increases|xcomp|circulating circulating|dobj|levels levels|compound|END_ENTITY	Valsartan increases circulating adiponectin levels without changing HOMA-IR in patients with type 2 diabetes_mellitus and hypertension .
10234113	0	Valsartan	0,9	angiotensin_II	17,31	Valsartan	angiotensin II	MESH:C081489	183	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Valsartan , a new angiotensin_II antagonist ; blood pressure reduction in essential hypertension compared with an angiotensin converting enzyme inhibitor , enalapril .
11881114	0	Valsartan	0,9	angiotensin_II	63,77	Valsartan	angiotensin II	MESH:C081489	183	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|effects effects|nmod|END_ENTITY	Valsartan and candesartan can inhibit deteriorating effects of angiotensin_II on coronary endothelial function .
16303640	0	Valsartan	0,9	angiotensin_II	84,98	Valsartan	angiotensin II	MESH:C081489	24179(Tax:10116)	Chemical	Gene	abolishes|nsubj|START_ENTITY abolishes|dobj|most most|nmod|effects effects|nmod|END_ENTITY	Valsartan abolishes most of the memory-improving effects of intracerebroventricular angiotensin_II in rats .
8841157	0	Valsartan	0,9	angiotensin_II	17,31	Valsartan	angiotensin II	MESH:C081489	183	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Valsartan , a new angiotensin_II antagonist for the treatment of essential hypertension : a comparative study of the efficacy and safety against amlodipine .
8986917	0	Valsartan	0,9	angiotensin_II	17,31	Valsartan	angiotensin II	MESH:C081489	183	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Valsartan , a new angiotensin_II antagonist for the treatment of essential hypertension : efficacy and safety compared with placebo and enalapril .
9218922	0	Valsartan	0,9	angiotensin_II	17,31	Valsartan	angiotensin II	MESH:C081489	183	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Valsartan , a new angiotensin_II antagonist for the treatment of essential hypertension : efficacy and safety compared to hydrochlorothiazide .
9220209	0	Valsartan	0,9	angiotensin_II	17,31	Valsartan	angiotensin II	MESH:C081489	183	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Valsartan , a new angiotensin_II antagonist : antihypertensive effects over 24 hours .
9322828	0	Valsartan	0,9	angiotensin_II	17,31	Valsartan	angiotensin II	MESH:C081489	183	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Valsartan , a new angiotensin_II antagonist for the treatment of essential hypertension : efficacy , tolerability and safety compared to an angiotensin-converting enzyme inhibitor , lisinopril .
12491811	0	Valsartan	37,46	angiotensin_II_type-1_receptor	60,90	Valsartan	angiotensin II type-1 receptor	MESH:C081489	81638(Tax:10116)	Chemical	Gene	START_ENTITY|appos|blocker blocker|amod|END_ENTITY	-LSB- Preclinical and clinical profile of Valsartan , a selective angiotensin_II_type-1_receptor blocker -RSB- .
19307231	0	Valsartan	0,9	angiotensin_II_type_1_receptor	39,69	Valsartan	angiotensin II type 1 receptor	MESH:C081489	185	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|interaction interaction|nmod|synthase synthase|amod|END_ENTITY	Valsartan regulates the interaction of angiotensin_II_type_1_receptor and endothelial nitric_oxide synthase via Src/PI3K/Akt signalling .
24599011	0	Valsartan	0,9	angiotensin_II_type_1_receptor	124,154	Valsartan	angiotensin II type 1 receptor	MESH:C081489	185	Chemical	Gene	ameliorates|nsubj|START_ENTITY ameliorates|dobj|pattern pattern|dep|role role|nmod|agonism agonism|nmod|END_ENTITY	Valsartan ameliorates the constitutive adipokine expression pattern in mature adipocytes : a role for inverse agonism of the angiotensin_II_type_1_receptor in obesity .
12417542	0	Valsartan	123,132	brain_natriuretic_peptide	36,61	Valsartan	brain natriuretic peptide	MESH:C081489	4879	Chemical	Gene	Trial|compound|START_ENTITY Effects|dep|Trial Effects|nmod|valsartan valsartan|acl|circulating circulating|dobj|END_ENTITY	Effects of valsartan on circulating brain_natriuretic_peptide and norepinephrine in symptomatic chronic_heart_failure : the Valsartan Heart Failure Trial -LRB- Val-HeFT -RRB- .
16820342	0	Valsartan	0,9	cystatin_C	24,34	Valsartan	cystatin C	MESH:C081489	1471	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	Valsartan reduces serum cystatin_C and the renal vascular resistance in patients with essential hypertension .
15820487	0	Valsartan	0,9	interleukin-1beta	18,35	Valsartan	interleukin-1beta	MESH:C081489	3553	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|secretion secretion|amod|END_ENTITY	Valsartan reduces interleukin-1beta secretion by peripheral blood mononuclear cells in patients with essential hypertension .
2100513	0	Vanadate	0,8	Glut-1	40,46	Vanadate	Glut-1	MESH:D014638	20525(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|appos|END_ENTITY	Vanadate regulates glucose_transporter -LRB- Glut-1 -RRB- expression in NIH3T3 mouse fibroblasts .
10400652	0	Vanadate	0,8	NF-kappaB	22,31	Vanadate	NF-kappaB	MESH:D014638	4790	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Vanadate induction of NF-kappaB involves IkappaB_kinase_beta and SAPK/ERK _ kinase_1 in macrophages .
1612011	0	Vanadate	0,8	glucose_transporter	118,137	Vanadate	glucose transporter	MESH:D014638	25139(Tax:10116)	Chemical	Gene	markedly|amod|START_ENTITY increases|nsubj|markedly increases|advcl|modifying modifying|dobj|expression expression|compound|END_ENTITY	Vanadate treatment markedly increases glucose utilization in muscle of insulin-resistant fa/fa rats without modifying glucose_transporter expression .
2100513	0	Vanadate	0,8	glucose_transporter	19,38	Vanadate	glucose transporter	MESH:D014638	20525(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Vanadate regulates glucose_transporter -LRB- Glut-1 -RRB- expression in NIH3T3 mouse fibroblasts .
3288633	0	Vanadate	0,8	insulin	37,44	Vanadate	insulin	MESH:D014638	3630	Chemical	Gene	cell|amod|START_ENTITY surface|nsubj|cell surface|dobj|receptors receptors|compound|END_ENTITY	Vanadate down-regulates cell surface insulin and growth hormone receptors and inhibits insulin_receptor degradation in cultured human lymphocytes .
9348211	0	Vanadate	0,8	insulin_receptor	36,52	Vanadate	insulin receptor	MESH:D014638	24954(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Vanadate , but not insulin , inhibits insulin_receptor gene expression in rat hepatoma cells .
9559669	0	Vanadate	0,8	insulin_receptor	26,42	Vanadate	insulin receptor	MESH:D014638	24954(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|xcomp|associated associated|nsubj|END_ENTITY	Vanadate fully stimulates insulin_receptor substrate-1 associated phosphatidyl_inositol 3-kinase activity in adipocytes from young and old rats .
1772424	0	Vanadate	0,8	ornithine_decarboxylase	20,43	Vanadate	ornithine decarboxylase	MESH:D014638	18263(Tax:10090)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|amod|END_ENTITY	Vanadate stimulates ornithine_decarboxylase activity in C3H/10T1/2 cells .
10439081	0	Vanadate	0,8	protein_tyrosine_phosphatases	23,52	Vanadate	protein tyrosine phosphatases	MESH:D014638	10076	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Vanadate inhibition of protein_tyrosine_phosphatases in Jurkat cells : modulation by redox state .
6244391	0	Vanadate	0,8	renin	18,23	Vanadate	renin	MESH:D014638	24715(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|compound|END_ENTITY	Vanadate inhibits renin secretion from rat kidney slices .
12083368	0	Vanadium	0,8	GLUT4	19,24	Vanadium	GLUT4	MESH:D014639	25139(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Vanadium increases GLUT4 in diabetic rat skeletal muscle .
3021234	0	Vanadium	0,8	transferrin	22,33	Vanadium	transferrin	MESH:D014639	24825(Tax:10116)	Chemical	Gene	complexes|amod|START_ENTITY complexes|nmod|END_ENTITY	Vanadium complexes of transferrin and ferritin in the rat .
7434044	0	Vancomycin	0,10	CSF	28,31	Vancomycin	CSF	MESH:D014640	1437	Chemical	Gene	penetration|nsubj|START_ENTITY penetration|nmod|END_ENTITY	Vancomycin penetration into CSF during treatment of patients receiving hemodialysis .
19319137	0	Vandetanib	0,10	VEGFR	37,42	Vandetanib	VEGFR	MESH:C452423	3791	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Vandetanib -LRB- ZD6474 -RRB- , an inhibitor of VEGFR and EGFR signalling , as a novel molecular-targeted therapy against cholangiocarcinoma .
21537841	0	Vandetanib	0,10	VEGFR-2	25,32	Vandetanib	VEGFR-2	MESH:C452423	3791	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Vandetanib inhibits both VEGFR-2 and EGFR signalling at clinically relevant drug levels in preclinical models of human cancer .
22611027	0	Vandetanib	0,10	VEGF_receptor-2	28,43	Vandetanib	VEGF receptor-2	MESH:C452423	16542(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Vandetanib , an inhibitor of VEGF_receptor-2 and EGF_receptor , suppresses tumor development and improves prognosis of liver_cancer in mice .
23783486	0	Vandetanib	0,10	p38	27,30	Vandetanib	p38	MESH:C452423	1432	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|amod|END_ENTITY	Vandetanib combined with a p38 MAPK inhibitor synergistically reduces glioblastoma cell survival .
19368348	0	Vanillin	0,8	PI3K	71,75	Vanillin	PI3K	MESH:C100058	5293	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|inhibition inhibition|compound|END_ENTITY	Vanillin suppresses metastatic potential of human cancer cells through PI3K inhibition and decreases angiogenesis in vivo .
23850265	0	Vanillin	0,8	Yap1	34,38	Vanillin	Yap1	MESH:C100058	855005(Tax:4932)	Chemical	Gene	causes|nsubj|START_ENTITY causes|dobj|activation activation|nmod|END_ENTITY	Vanillin causes the activation of Yap1 and mitochondrial fragmentation in Saccharomyces_cerevisiae .
18835982	0	Vanillin	0,8	matrix_metalloproteinase-9	18,44	Vanillin	matrix metalloproteinase-9	MESH:C100058	4318	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Vanillin inhibits matrix_metalloproteinase-9 expression through down-regulation of nuclear factor-kappaB signaling pathway in human hepatocellular_carcinoma cells .
16389550	0	Vanilloid	0,9	TRPV1	20,25	Vanilloid	TRPV1	null	193034(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Vanilloid receptor -LRB- TRPV1 -RRB- - deficient mice show increased susceptibility to dinitrobenzene_sulfonic_acid induced colitis .
17109831	0	Vanilloid	0,9	TRPV1	22,27	Vanilloid	TRPV1	null	7442	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Vanilloid receptor 1 -LRB- TRPV1 -RRB- expression in lingual nerve neuromas from patients with or without symptoms of burning_pain .
26366213	0	Vaproic_Acid	34,46	Histone_Deacetylase	4,23	Vaproic Acid	Histone Deacetylase	null	9734	Chemical	Gene	Growth|compound|START_ENTITY Growth|compound|END_ENTITY	The Histone_Deacetylase Inhibitor Vaproic_Acid Induces Cell Growth Arrest in Hepatocellular_Carcinoma Cells via Suppressing Notch Signaling .
15312980	0	Vardenafil	0,10	phosphodiesterase-5	92,111	Vardenafil	phosphodiesterase-5	MESH:C426063	8654	Chemical	Gene	START_ENTITY|dep|basis basis|nmod|potency potency|nmod|sildenafil sildenafil|nmod|END_ENTITY	Vardenafil : structural basis for higher potency over sildenafil in inhibiting cGMP-specific phosphodiesterase-5 -LRB- PDE5 -RRB- .
20803229	0	Vardenafil	0,10	phosphodiesterase-5	28,47	Vardenafil	phosphodiesterase-5	MESH:C426063	8654	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Vardenafil , an inhibitor of phosphodiesterase-5 , blocks advanced glycation end product -LRB- AGE -RRB- - induced up-regulation of monocyte_chemoattractant_protein-1 mRNA levels in endothelial cells by suppressing AGE receptor -LRB- RAGE -RRB- expression via elevation of cGMP .
19129734	0	Varespladib	0,11	secretory_phospholipase_A2	23,49	Varespladib	secretory phospholipase A2	MESH:C117948	18780(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Varespladib -LRB- A-002 -RRB- , a secretory_phospholipase_A2 inhibitor , reduces atherosclerosis and aneurysm formation in ApoE - / - mice .
21602519	0	Varespladib	0,11	secretory_phospholipase_A2	21,47	Varespladib	secretory phospholipase A2	MESH:C117948	8399	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Varespladib inhibits secretory_phospholipase_A2 in bronchoalveolar lavage of different types of neonatal_lung_injury .
9223548	0	Variabilin	0,10	phospholipase_A2	62,78	Variabilin	phospholipase A2	null	151056	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	Variabilin : a dual inhibitor of human secretory and cytosolic phospholipase_A2 with anti-inflammatory activity .
8797149	0	Vasomolol	0,9	beta_1-adrenoceptor	65,84	Vasomolol	beta 1-adrenoceptor	MESH:C101861	24925(Tax:10116)	Chemical	Gene	START_ENTITY|dep|antagonist antagonist|amod|END_ENTITY	Vasomolol : an ultra short-acting and vasorelaxant vanilloid type beta_1-adrenoceptor antagonist .
8620601	0	Vasopressin	0,11	Ca2	23,26	Vasopressin	Ca2	MESH:D014667	54231(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|amod|END_ENTITY	Vasopressin stimulates Ca2 + spiking activity in A7r5 vascular smooth muscle cells via activation of phospholipase A2 .
17684103	0	Vasopressin	0,11	IRAP	82,86	Vasopressin	IRAP	MESH:D014667	240028(Tax:10090)	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Vasopressin is a physiological substrate for the insulin-regulated_aminopeptidase IRAP .
19390537	0	Vasopressin	0,11	NKCC1	41,46	Vasopressin	NKCC1	MESH:D014667	83629(Tax:10116)	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Vasopressin and hyperosmolality regulate NKCC1 expression in rat OMCD .
20576681	0	Vasopressin	0,11	Slc14a2	61,68	Vasopressin	Slc14a2	MESH:D014667	54302(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|nmod|END_ENTITY	Vasopressin increases phosphorylation of Ser84 and Ser486 in Slc14a2 collecting duct urea transporters .
2955705	0	Vasopressin	0,11	V1a	61,64	Vasopressin	V1a	MESH:D014667	25107(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY resemble|nsubj|receptors resemble|xcomp|type type|amod|END_ENTITY	Vasopressin receptors from cultured mesangial cells resemble V1a type .
8701029	0	Vasopressin	0,11	V1a	73,76	Vasopressin	V1a	MESH:D014667	25107(Tax:10116)	Chemical	Gene	potentiation|compound|START_ENTITY potentiation|nmod|pathway pathway|nmod|receptors receptors|amod|END_ENTITY	Vasopressin potentiation of the melatonin synthetic pathway via specific V1a receptors in the rat pineal gland .
18951114	0	Vasopressin	0,11	V2R	72,75	Vasopressin	V2R	MESH:D014667	12000(Tax:10090)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|nmod|END_ENTITY	Vasopressin decreases sepsis-induced pulmonary_inflammation through the V2R .
26820216	0	Vasopressin	0,11	angiotensin_II	77,91	Vasopressin	angiotensin II	MESH:D014667	24179(Tax:10116)	Chemical	Gene	system|amod|START_ENTITY mediate|nsubj|system mediate|dobj|effects effects|nmod|END_ENTITY	Vasopressin and sympathetic system mediate the cardiovascular effects of the angiotensin_II in the bed nucleus of the stria terminalis in rat .
3051054	0	Vasopressin	0,11	angiotensin_II	90,104	Vasopressin	angiotensin II	MESH:D014667	24179(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY mediated|nsubjpass|release mediated|nmod|END_ENTITY	Vasopressin release induced by intracranial injection of eledoisin is mediated by central angiotensin_II .
6509326	0	Vasopressin	0,11	angiotensin_II	46,60	Vasopressin	angiotensin II	MESH:D014667	24179(Tax:10116)	Chemical	Gene	release|nsubj|START_ENTITY release|nmod|END_ENTITY	Vasopressin release to central and peripheral angiotensin_II in rats with lesions of the subfornical organ .
9653883	0	Vasopressin	0,11	angiotensin_II	54,68	Vasopressin	angiotensin II	MESH:D014667	24179(Tax:10116)	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|dobj|effect effect|nmod|END_ENTITY	Vasopressin mediates the inhibitory effect of central angiotensin_II on cerebrospinal fluid formation .
20504373	0	Vaticanol_C	0,11	PPARalpha	47,56	Vaticanol C	PPARalpha	MESH:C459559	19013(Tax:10090)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Vaticanol_C , a resveratrol tetramer , activates PPARalpha and PPARbeta/delta in vitro and in vivo .
2898903	0	Vecuronium	0,10	histamine_N-methyltransferase	20,49	Vecuronium	histamine N-methyltransferase	MESH:D014673	3176	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Vecuronium inhibits histamine_N-methyltransferase .
24235081	0	Velcalcetide	0,12	parathyroid_hormone	95,114	Velcalcetide	parathyroid hormone	null	5741	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	Velcalcetide -LRB- AMG_416 -RRB- , a novel peptide agonist of the calcium-sensing receptor , reduces serum parathyroid_hormone and FGF23 levels in healthy male subjects .
22028422	0	Vemurafenib	0,11	BRAF	64,68	Vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	Vemurafenib -LRB- PLX4032 -RRB- : an orally available inhibitor of mutated BRAF for the treatment of metastatic_melanoma .
22646766	0	Vemurafenib	0,11	BRAF	52,56	Vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nummod|END_ENTITY	Vemurafenib -LRB- RG67204 , PLX4032 -RRB- : a potent , selective BRAF kinase inhibitor .
22742884	0	Vemurafenib	0,11	BRAF	29,33	Vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|melanoma melanoma|compound|END_ENTITY	Vemurafenib in patients with BRAF V600E mutation-positive advanced melanoma .
23116250	0	Vemurafenib	0,11	BRAF	44,48	Vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	START_ENTITY|dep|inhibition inhibition|nmod|END_ENTITY	Vemurafenib : targeted inhibition of mutated BRAF for treatment of advanced melanoma and its potential in other malignancies .
23134356	1	Vemurafenib	67,78	BRAF	144,148	Vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	extends|nsubj|START_ENTITY extends|nmod|patients patients|nmod|melanoma melanoma|compound|END_ENTITY	Vemurafenib , a selective RAF inhibitor , extends survival among patients with BRAF V600E-mutant melanoma .
23483066	0	Vemurafenib	0,11	BRAF	38,42	Vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	MHC|compound|START_ENTITY MHC|acl|induction induction|nmod|END_ENTITY	Vemurafenib enhances MHC induction in BRAF -LRB- V600E -RRB- homozygous melanoma cells .
24114739	0	Vemurafenib	0,11	BRAF	64,68	Vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	START_ENTITY|nmod|treatment treatment|nmod|V600 V600|compound|END_ENTITY	Vemurafenib for the treatment of locally advanced or metastatic BRAF V600 mutation-positive malignant_melanoma : a NICE single technology appraisal .
24335681	0	Vemurafenib	0,11	BRAF	25,29	Vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	START_ENTITY|dobj|treatment treatment|nmod|peripheral_nerve_sheath_tumor peripheral_nerve_sheath_tumor|compound|END_ENTITY	Vemurafenib treatment of BRAF V600E-mutated malignant peripheral_nerve_sheath_tumor .
24582505	0	Vemurafenib	0,11	BRAF	29,33	Vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	Vemurafenib in patients with BRAF -LRB- V600 -RRB- mutated metastatic_melanoma : an open-label , multicentre , safety study .
24987354	0	Vemurafenib	75,86	BRAF	33,37	Vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	Response|nmod|START_ENTITY Response|nmod|Papillary_Thyroid_Carcinoma Papillary_Thyroid_Carcinoma|compound|END_ENTITY	Extended Antitumor Response of a BRAF V600E Papillary_Thyroid_Carcinoma to Vemurafenib .
25706985	0	Vemurafenib	27,38	BRAF	42,46	Vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	Trametinib|nmod|START_ENTITY Trametinib|nmod|Non-Small_Cell_Lung_Cancer Non-Small_Cell_Lung_Cancer|compound|END_ENTITY	Trametinib with or without Vemurafenib in BRAF Mutated Non-Small_Cell_Lung_Cancer .
26287849	0	Vemurafenib	0,11	BRAF	49,53	Vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	START_ENTITY|nmod|Mutations Mutations|compound|END_ENTITY	Vemurafenib in Multiple_Nonmelanoma_Cancers with BRAF V600 Mutations .
26857260	0	Vemurafenib	79,90	BRAF	20,24	Vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	Therapy|compound|START_ENTITY Cessation|nmod|Therapy Cessation|compound|END_ENTITY	Ongoing Response in BRAF V600E-Mutant Melanoma After Cessation of Intermittent Vemurafenib Therapy : A Case Report .
26984388	0	Vemurafenib	17,28	BRAF	42,46	Vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	START_ENTITY|dep|Review Review|nmod|Mutation-Positive Mutation-Positive|compound|END_ENTITY	Cobimetinib Plus Vemurafenib : A Review in BRAF -LRB- V600 -RRB- Mutation-Positive Unresectable or Metastatic_Melanoma .
26989536	0	Vemurafenib	54,65	BRAF	104,108	Vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	Survival|nmod|START_ENTITY Survival|nmod|Mutation Mutation|compound|END_ENTITY	Long Term Survival and Continued Complete Response of Vemurafenib in a Metastatic_Melanoma Patient with BRAF V600K Mutation .
26532546	0	Vemurafenib	22,33	Braf	77,81	Vemurafenib	Braf	MESH:C551177	673	Chemical	Gene	Cost-Effectiveness|nmod|START_ENTITY Cost-Effectiveness|nmod|Patients Patients|nmod|Unresectable Unresectable|compound|END_ENTITY	Cost-Effectiveness of Vemurafenib as a First-Line Treatment in Patients with Braf V600 Mutation-Positive Unresectable or Metastatic_Melanoma in Spain .
20396432	0	Venlafaxine	15,26	HSP70	66,71	Venlafaxine	HSP70	MESH:C047426	266759(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	The Effects of Venlafaxine and Dexamethasone on the Expression of HSP70 in Rat C6 Glioma Cells .
17191263	0	Venlafaxine	0,11	P-glycoprotein	20,34	Venlafaxine	P-glycoprotein	MESH:C047426	5243	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Venlafaxine induces P-glycoprotein in human Caco-2 cells .
21605706	0	Venlafaxine	0,11	P-glycoprotein	102,116	Venlafaxine	P-glycoprotein	MESH:C047426	67078(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|regulation regulation|nmod|END_ENTITY	Venlafaxine inhibits the development and differentiation of dendritic cells through the regulation of P-glycoprotein .
19464349	0	Venlafaxine	0,11	brain-derived_neurotrophic_factor	47,80	Venlafaxine	brain-derived neurotrophic factor	MESH:C047426	24225(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY stimulates|nsubj|treatment stimulates|dobj|expression expression|nmod|protein protein|amod|END_ENTITY	Venlafaxine treatment stimulates expression of brain-derived_neurotrophic_factor protein in frontal cortex and inhibits long-term potentiation in hippocampus .
25197330	0	Venlafaxine	0,11	brain-derived_neurotrophic_factor	71,104	Venlafaxine	brain-derived neurotrophic factor	MESH:C047426	24225(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Venlafaxine inhibits apoptosis of hippocampal neurons by up-regulating brain-derived_neurotrophic_factor in a rat depression model .
25951665	0	Venlafaxine	0,11	brain-derived_neurotrophic_factor	71,104	Venlafaxine	brain-derived neurotrophic factor	MESH:C047426	24225(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Venlafaxine inhibits apoptosis of hippocampal neurons by up-regulating brain-derived_neurotrophic_factor in a rat depression model .
8556338	0	Verapamil	0,9	GFAP	46,50	Verapamil	GFAP	MESH:D014700	24387(Tax:10116)	Chemical	Gene	attenuates|amod|START_ENTITY END_ENTITY|nsubj|attenuates	Verapamil treatment attenuates immunoreactive GFAP at cerebral cortical lesion site .
16415090	0	Verapamil	0,9	P-glycoprotein	10,24	Verapamil	P-glycoprotein	MESH:D014700	287115(Tax:10116)	Chemical	Gene	transport|amod|START_ENTITY transport|amod|END_ENTITY	Verapamil P-glycoprotein transport across the rat blood-brain barrier : cyclosporine , a concentration inhibition analysis , and comparison with human data .
16531326	0	Verapamil	0,9	P-glycoprotein	34,48	Verapamil	P-glycoprotein	MESH:D014700	5243	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|upregulation upregulation|nmod|expression expression|amod|END_ENTITY	Verapamil induces upregulation of P-glycoprotein expression on human monocyte derived dendritic cells .
19212940	0	Verapamil	0,9	P-glycoprotein	60,74	Verapamil	P-glycoprotein	MESH:D014700	287115(Tax:10116)	Chemical	Gene	START_ENTITY|dep|role role|nmod|transporter transporter|amod|END_ENTITY	Verapamil in treatment_resistant_depression : a role for the P-glycoprotein transporter ?
1972632	0	Verapamil	0,9	P-glycoprotein	101,115	Verapamil	P-glycoprotein	MESH:D014700	5243	Chemical	Gene	sensitize|nsubj|START_ENTITY sensitize|xcomp|vincristine vincristine|nmod|concentration concentration|nmod|absence absence|nmod|END_ENTITY	Verapamil and cyclosporin_A sensitize human kidney_tumor cells to vincristine in absence of membrane P-glycoprotein and without apparent changes in the cytoplasmic free Ca2 + concentration .
3189539	0	Verapamil	0,9	PTH	18,21	Verapamil	PTH	MESH:D014700	24694(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|resistance resistance|compound|END_ENTITY	Verapamil induces PTH resistance but increases duodenal calcium absorption in rats .
3210537	0	Verapamil	0,9	PTH	19,22	Verapamil	PTH	MESH:D014700	24694(Tax:10116)	Chemical	Gene	reverses|nsubj|START_ENTITY reverses|dobj|END_ENTITY	Verapamil reverses PTH - or CRF-induced abnormal fatty_acid oxidation in muscle .
2266342	0	Verapamil	0,9	alkaline_phosphatase	26,46	Verapamil	alkaline phosphatase	MESH:D014700	250	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Verapamil increases serum alkaline_phosphatase in hypertensive patients .
25330767	0	Verapamil	0,9	interleukin-5	20,33	Verapamil	interleukin-5	MESH:D014700	3567	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|secretion secretion|amod|END_ENTITY	Verapamil modulates interleukin-5 and interleukin-6 secretion in organotypic human sinonasal polyp explants .
14615256	0	Verapamil	0,9	interleukin-6	19,32	Verapamil	interleukin-6	MESH:D014700	3569	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Verapamil inhibits interleukin-6 and vascular_endothelial_growth_factor production in primary cultures of keloid fibroblasts .
25625052	0	Verapamil	0,9	p-glycoprotein	33,47	Verapamil	p-glycoprotein	MESH:D014700	287115(Tax:10116)	Chemical	Gene	effect|compound|START_ENTITY effect|nmod|expression expression|amod|END_ENTITY	Verapamil and rifampin effect on p-glycoprotein expression in hepatocellular_carcinoma .
2410986	0	Verapamil	0,9	substance_P	50,61	Verapamil	substance P	MESH:D014700	6863	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Verapamil inhibition of the intestinal effects of substance_P .
26329367	0	Veratric_Acid	0,13	IL-6	35,39	Veratric Acid	IL-6	MESH:C009333	3569	Chemical	Gene	Inhibits|nsubj|START_ENTITY Inhibits|dobj|END_ENTITY	Veratric_Acid Inhibits LPS-Induced IL-6 and IL-8 Production in Human Gingival Fibroblasts .
21967458	0	Vernolide-A	0,11	HIF-1a	89,95	Vernolide-A	HIF-1a	MESH:C558651	15251(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|regulating regulating|dobj|END_ENTITY	Vernolide-A inhibits radiation-induced hypoxia-mediated tumor angiogenesis by regulating HIF-1a , MMP-2 , MMP-9 , and VEGF .
26318254	0	Verproside	0,10	MUC5AC	34,40	Verproside	MUC5AC	MESH:C512483	4586	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Verproside inhibits TNF-a-induced MUC5AC expression through suppression of the TNF-a/NF-kB pathway in human airway epithelial cells .
20687907	0	Vertebrate	0,10	Hedgehog	11,19	Vertebrate	Hedgehog	null	42737(Tax:7227)	Chemical	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	Vertebrate Hedgehog signaling : cilia rule .
12853488	0	Vertebrate	0,10	HoxB	11,15	Vertebrate	HoxB	null	15406(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Vertebrate HoxB gene expression requires DNA replication .
16663706	0	Vertebrate	83,93	NAD_Kinase	18,28	Vertebrate	NAD Kinase	null	419403(Tax:9031)	Chemical	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|END_ENTITY	Comparison of the NAD_Kinase and Myosin_Light_Chain_Kinase Activator Properties of Vertebrate , Higher Plant , and Algal Calmodulins .
26361148	0	Verteporfin	0,11	YAP	47,50	Verteporfin	YAP	MESH:C098350	10413	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|compound|END_ENTITY	Verteporfin without light stimulation inhibits YAP activation in trabecular meshwork cells : Implications for glaucoma treatment .
23393163	0	Vesnarinone	0,11	TNFa	23,27	Vesnarinone	TNFa	MESH:C041667	7124	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Vesnarinone suppresses TNFa mRNA expression by inhibiting valosin-containing_protein .
935646	0	Vidarabine	95,105	adenosine_deaminase	13,32	Vidarabine	adenosine deaminase	MESH:D014740	100	Chemical	Gene	Effect|appos|START_ENTITY Effect|nmod|inhibitor inhibitor|amod|END_ENTITY	Effect of an adenosine_deaminase inhibitor on the uptake and metabolism of arabinosyl_adenine -LRB- Vidarabine -RRB- by intact human erythrocytes .
15122710	0	Vigabatrin	0,10	GABA-transaminase	16,33	Vigabatrin	GABA-transaminase	MESH:D020888	81632(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Vigabatrin , the GABA-transaminase inhibitor , damages cone photoreceptors in rats .
17221143	0	Vigabatrin	0,10	GABA_transaminase	14,31	Vigabatrin	GABA transaminase	MESH:D020888	81632(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Vigabatrin , a GABA_transaminase inhibitor , reversibly eliminates tinnitus in an animal model .
24725430	0	Vigilin	0,7	CCCTC-binding_factor	23,43	Vigilin	CCCTC-binding factor	null	10664	Chemical	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Vigilin interacts with CCCTC-binding_factor -LRB- CTCF -RRB- and is involved in CTCF-dependent regulation of the imprinted genes Igf2 and H19 .
22607704	0	Vigilin	0,7	signal_peptide_peptidase	23,47	Vigilin	signal peptide peptidase	null	81502	Chemical	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Vigilin interacts with signal_peptide_peptidase .
19499624	0	Vilazodone	0,10	5-HT1A	14,20	Vilazodone	5-HT1A	MESH:C494040	24473(Tax:10116)	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Vilazodone : a 5-HT1A receptor agonist/serotonin _ transporter inhibitor for the treatment of affective_disorders .
27040795	0	Vilazodone	0,10	5-HT1A	95,101	Vilazodone	5-HT1A	MESH:C494040	24473(Tax:10116)	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|advcl|paroxetine paroxetine|nmod|receptors receptors|nummod|END_ENTITY	Vilazodone does not inhibit sexual behavior in male rats in contrast to paroxetine : A role for 5-HT1A receptors ?
16969429	0	Vildagliptin	0,12	DPP-4	22,27	Vildagliptin	DPP-4	MESH:C502012	1803	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Vildagliptin : a novel DPP-4 inhibitor with pancreatic islet enhancement activity for treatment of patients with type 2 diabetes .
24837407	0	Vildagliptin	0,12	DPP-4	17,22	Vildagliptin	DPP-4	MESH:C502012	1803	Chemical	Gene	inhibitor|advcl|START_ENTITY inhibitor|nsubj|END_ENTITY	Vildagliptin , a DPP-4 inhibitor for the twice-daily treatment of type_2_diabetes_mellitus with or without metformin .
20082866	0	Vildagliptin	54,66	DPP-IV	35,41	Vildagliptin	DPP-IV	MESH:C502012	25253(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|appos|END_ENTITY	Effect of dipeptidyl_peptidase-IV -LRB- DPP-IV -RRB- inhibitor -LRB- Vildagliptin -RRB- on peripheral nerves in streptozotocin-induced diabetic rats .
15907807	0	Vildagliptin	70,82	dipeptidyl-peptidase_IV	14,37	Vildagliptin	dipeptidyl-peptidase IV	MESH:C502012	1803	Chemical	Gene	catalyzed|nmod|START_ENTITY catalyzed|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of dipeptidyl-peptidase_IV catalyzed peptide truncation by Vildagliptin -LRB- -LRB- 2S -RRB- - -LCB- -LSB- -LRB- 3-hydroxyadamantan-1-yl -RRB- amino -RSB- acetyl -RCB- - pyrrolidine-2-carbonitrile -RRB- .
16548792	0	Vildagliptin	0,12	dipeptidyl_peptidase-4	30,52	Vildagliptin	dipeptidyl peptidase-4	MESH:C502012	1803	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	Vildagliptin : an inhibitor of dipeptidyl_peptidase-4 with antidiabetic properties .
24547938	0	Vildagliptin	0,12	dipeptidyl_peptidase-4	17,39	Vildagliptin	dipeptidyl peptidase-4	MESH:C502012	1803	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Vildagliptin , a dipeptidyl_peptidase-4 inhibitor , for the treatment of type 2 diabetes .
15886245	0	Vildagliptin	0,12	dipeptidyl_peptidase-IV	16,39	Vildagliptin	dipeptidyl peptidase-IV	MESH:C502012	1803	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Vildagliptin , a dipeptidyl_peptidase-IV inhibitor , improves model-assessed beta-cell function in patients with type 2 diabetes .
20082866	0	Vildagliptin	54,66	dipeptidyl_peptidase-IV	10,33	Vildagliptin	dipeptidyl peptidase-IV	MESH:C502012	25253(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Effect of dipeptidyl_peptidase-IV -LRB- DPP-IV -RRB- inhibitor -LRB- Vildagliptin -RRB- on peripheral nerves in streptozotocin-induced diabetic rats .
23723123	0	Vinblastine	0,11	NOXA	28,32	Vinblastine	NOXA	MESH:D014747	5366	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Vinblastine rapidly induces NOXA and acutely sensitizes primary chronic_lymphocytic_leukemia cells to ABT-737 .
25552705	0	Vincristine	0,11	CD22	73,77	Vincristine	CD22	MESH:D014750	933	Chemical	Gene	START_ENTITY|nmod|patients patients|compound|END_ENTITY	Vincristine , dexamethasone and epratuzumab for older relapsed/refractory CD22 + B-acute_lymphoblastic_leukemia patients : a Phase 2 Study .
21835258	0	Vincristine	91,102	P-glycoprotein	122,136	Vincristine	P-glycoprotein	MESH:D014750	5243	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	The COX-2 inhibitor Celecoxib enhances the sensitivity of KB/VCR oral_cancer cell lines to Vincristine by down-regulating P-glycoprotein expression and function .
18052208	0	Vinflunine	0,10	STOP	117,121	Vinflunine	STOP	MESH:C111217	4135	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	Vinflunine , a novel microtubule inhibitor , suppresses calmodulin interaction with the microtubule-associated protein STOP .
15641480	0	Vinorelbine	0,11	interleukin-2	32,45	Vinorelbine	interleukin-2	MESH:C030852	3558	Chemical	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	Vinorelbine in combination with interleukin-2 as second-line treatment in patients with metastatic_melanoma .
25450700	0	Violacein	0,9	CXCR4	53,58	Violacein	CXCR4	MESH:C063155	7852	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Violacein inhibits matrix metalloproteinase mediated CXCR4 expression : potential anti-tumor effect in cancer invasion and metastasis .
26114475	0	Viroporins	33,43	NLRP3	0,5	Viroporins	NLRP3	null	114548	Chemical	Gene	Activation|nmod|START_ENTITY Activation|compound|END_ENTITY	NLRP3 Inflammasome Activation by Viroporins of Animal Viruses .
18351336	0	Virulizin	0,9	IL-17E	32,38	Virulizin	IL-17E	null	64806	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|nmod|END_ENTITY	Virulizin induces production of IL-17E to enhance antitumor activity by recruitment of eosinophils into tumors .
17673150	0	Virulizin	0,9	TNFalpha	51,59	Virulizin	TNFalpha	null	21926(Tax:10090)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	Virulizin , a novel immunotherapy agent , stimulates TNFalpha expression in monocytes/macrophages in vitro and in vivo .
21767632	0	Viscolin	0,8	VCAM-1	17,23	Viscolin	VCAM-1	MESH:C513809	7412	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|compound|END_ENTITY	Viscolin reduces VCAM-1 expression in TNF-a-treated endothelial cells via the JNK/NF-kB and ROS pathway .
24129003	8	Vit_E	1239,1244	PQQ	1247,1250	Vit E	Vit	null	313831(Tax:10116)	Chemical	Gene	combination|compound|START_ENTITY combination|compound|END_ENTITY	Functional and electrophysiological studies , and gastrocnemius muscle mass measurement confirmed faster and better recovery of regenerated axons in Vit_E + PQQ combination compared to Vit_E or PQQ solely -LRB- P < 0.05 -RRB- .
16120438	0	Vitamin_A	0,9	BMP4	24,28	Vitamin A	BMP4	MESH:D014801	12159(Tax:10090)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Vitamin_A regulation of BMP4 expression in the male germ line .
25985851	0	Vitamin_A	14,23	FoxP3	43,48	Vitamin A	FoxP3	MESH:D014801	50943	Chemical	Gene	Supplementation|compound|START_ENTITY Supplementation|nmod|END_ENTITY	The Effect of Vitamin_A Supplementation on FoxP3 and TGF-b Gene Expression in Avonex-Treated Multiple_Sclerosis Patients .
25985851	0	Vitamin_A	14,23	FoxP3	43,48	Vitamin A	FoxP3	MESH:D014801	50943	Chemical	Gene	Supplementation|compound|START_ENTITY Supplementation|nmod|END_ENTITY	The Effect of Vitamin_A Supplementation on FoxP3 and TGF-b Gene Expression in Avonex-Treated Multiple_Sclerosis Patients .
8609382	0	Vitamin_A	0,9	IFN-gamma	29,38	Vitamin A	IFN-gamma	MESH:D014801	15978(Tax:10090)	Chemical	Gene	down-regulation|compound|START_ENTITY down-regulation|nmod|synthesis synthesis|amod|END_ENTITY	Vitamin_A down-regulation of IFN-gamma synthesis in cloned mouse Th1 lymphocytes depends on the CD28 costimulatory pathway .
15313187	0	Vitamin_A	0,9	RANKL	35,40	Vitamin A	RANKL	MESH:D014801	8600	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Vitamin_A differentially regulates RANKL and OPG expression in human osteoblasts .
26343735	0	Vitamin_A	0,9	STRA6	78,83	Vitamin A	STRA6	MESH:D014801	64220	Chemical	Gene	Mechanism|compound|START_ENTITY Mechanism|nmod|END_ENTITY	Vitamin_A Transport Mechanism of the Multitransmembrane Cell-Surface Receptor STRA6 .
24024773	0	Vitamin_A	0,9	Th1	36,39	Vitamin A	Th1	MESH:D014801	51497	Chemical	Gene	supplementation|compound|START_ENTITY supplementation|amod|END_ENTITY	Vitamin_A supplementation and serum Th1 - and Th2-associated cytokine response in women .
6968676	0	Vitamin_A	0,9	epidermal_growth_factor	46,69	Vitamin A	epidermal growth factor	MESH:D014801	1950	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|effect effect|nmod|END_ENTITY	Vitamin_A potentiates the mitogenic effect of epidermal_growth_factor in cultures of normal adult human skin fibroblasts .
9649586	0	Vitamin_A	0,9	interleukin-4	95,108	Vitamin A	interleukin-4	MESH:D014801	3565	Chemical	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	Vitamin_A is required for regulation of polymeric immunoglobulin receptor -LRB- pIgR -RRB- expression by interleukin-4 and interferon-gamma in a human intestinal epithelial cell line .
24768685	0	Vitamin_A	0,9	nerve_growth_factor	20,39	Vitamin A	nerve growth factor	MESH:D014801	310738(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Vitamin_A increases nerve_growth_factor and retinoic_acid_receptor_beta and improves diabetic_neuropathy in rats .
408151	0	Vitamin_A	0,9	parathyroid_hormone	25,44	Vitamin A	parathyroid hormone	MESH:D014801	280903(Tax:9913)	Chemical	Gene	stimulation|compound|START_ENTITY stimulation|nmod|END_ENTITY	Vitamin_A stimulation of parathyroid_hormone : interactions with calcium , hydrocortisone , and vitamin_E in bovine parathyroid tissues and effects of vitamin_A in man .
3558401	0	Vitamin_A	0,9	retinol-binding_protein	22,45	Vitamin A	retinol-binding protein	MESH:D014801	281444(Tax:9913)	Chemical	Gene	uptake|nsubj|START_ENTITY uptake|nmod|END_ENTITY	Vitamin_A uptake from retinol-binding_protein in a cell-free system from pigment epithelial cells of bovine retina .
805200	0	Vitamin_A	0,9	retinol-binding_protein	73,96	Vitamin A	retinol-binding protein	MESH:D014801	396449(Tax:9031)	Chemical	Gene	transport|compound|START_ENTITY transport|dep|isolation isolation|nmod|END_ENTITY	Vitamin_A transport in chicken plasma : isolation and characterization of retinol-binding_protein -LRB- RBP -RRB- , prealbumin -LRB- PA -RRB- , and RBP -- PA complex .
8541334	0	Vitamin_A	0,9	retinyl_ester_hydrolase	92,115	Vitamin A	retinyl ester hydrolase	MESH:D014801	24346(Tax:10116)	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Vitamin_A contained in the lipid droplets of rat liver stellate cells is substrate for acid retinyl_ester_hydrolase .
22192505	0	Vitamin_A	0,9	rhodopsin	20,29	Vitamin A	rhodopsin	MESH:D014801	6010	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Vitamin_A activates rhodopsin and sensitizes it to ultraviolet light .
24626782	0	Vitamin_B	0,9	p53	23,26	Vitamin B	p53	null	22060(Tax:10090)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Vitamin_B activates p53 and elevates p21 gene expression in cancer cells and the mouse colon .
26158281	0	Vitamin_B12	42,53	Insulin	30,37	Vitamin B12	Insulin	MESH:D014805	3630	Chemical	Gene	Nanoparticles|compound|START_ENTITY Delivery|nmod|Nanoparticles Delivery|nmod|END_ENTITY	Efficient Peroral Delivery of Insulin via Vitamin_B12 Modified Trimethyl Chitosan Nanoparticles .
26260673	0	Vitamin_B12	95,106	Intrinsic_Factor	65,81	Vitamin B12	Intrinsic Factor	MESH:D014805	2694	Chemical	Gene	Conjugate|compound|START_ENTITY Binding|nmod|Conjugate Binding|compound|END_ENTITY	Enhanced Peptide Stability Against Protease Digestion Induced by Intrinsic_Factor Binding of a Vitamin_B12 Conjugate of Exendin-4 .
7578366	0	Vitamin_B12	0,11	granulocyte-colony_stimulating_factor	47,84	Vitamin B12	granulocyte-colony stimulating factor	MESH:D014805	1440	Chemical	Gene	mediated|nsubj|START_ENTITY mediated|nmod|END_ENTITY	Vitamin_B12 mediated oral delivery systems for granulocyte-colony_stimulating_factor and erythropoietin .
25486369	0	Vitamin_B12	0,11	insulin	59,66	Vitamin B12	insulin	MESH:D014805	3630	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	Vitamin_B12 in obese adolescents with clinical features of insulin resistance .
26685755	0	Vitamin_B12	0,11	insulin	146,153	Vitamin B12	insulin	MESH:D014805	3630	Chemical	Gene	layer|amod|START_ENTITY layer|dep|carrier carrier|nmod|delivery delivery|nmod|END_ENTITY	Vitamin_B12 functionalized layer by layer calcium_phosphate nanoparticles : A mucoadhesive and pH responsive carrier for improved oral delivery of insulin .
4974985	0	Vitamin_B12	0,11	intrinsic_factor	74,90	Vitamin B12	intrinsic factor	MESH:D014805	2694	Chemical	Gene	uptake|nsubj|START_ENTITY uptake|nmod|END_ENTITY	Vitamin_B12 uptake by human small bowel homogenate and its enhancement by intrinsic_factor .
14646334	0	Vitamin_B12	0,11	methionine_synthase	43,62	Vitamin B12	methionine synthase	MESH:D014805	81522(Tax:10116)	Chemical	Gene	determinant|nsubj|START_ENTITY determinant|nmod|activity activity|compound|END_ENTITY	Vitamin_B12 is a strong determinant of low methionine_synthase activity and DNA hypomethylation in gastrectomized rats .
22953941	0	Vitamin_C	0,9	14-3-3	63,69	Vitamin C	14-3-3	MESH:D001205	10971	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|down-regulation down-regulation|nmod|END_ENTITY	Vitamin_C induces apoptosis in AGS cells by down-regulation of 14-3-3 via a mitochondrial dependent pathway .
15917194	0	Vitamin_C	0,9	CD40	42,46	Vitamin C	CD40	MESH:D001205	958	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Vitamin_C inhibits platelet expression of CD40 ligand .
20163451	0	Vitamin_C	0,9	ERK	21,24	Vitamin C	ERK	MESH:D001205	5594	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|END_ENTITY	Vitamin_C attenuates ERK signalling to inhibit the regulation of collagen production by LL-37 in human dermal fibroblasts .
26628999	0	Vitamin_C	0,9	HIF-1a	127,133	Vitamin C	HIF-1a	MESH:D001205	3091	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|nmod|END_ENTITY	Vitamin_C inhibit the proliferation , migration and epithelial-mesenchymal-transition of lens epithelial cells by destabilizing HIF-1a .
23963652	0	Vitamin_C	0,9	Nanog	19,24	Vitamin C	Nanog	MESH:D001205	79923	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|xcomp|END_ENTITY	Vitamin_C enhances Nanog expression via activation of the JAK/STAT signaling pathway .
11401473	0	Vitamin_C	0,9	P53	93,96	Vitamin C	P53	MESH:D001205	7157	Chemical	Gene	augments|nsubj|START_ENTITY augments|advcl|stabilizing stabilizing|dobj|END_ENTITY	Vitamin_C augments chemotherapeutic response of cervical_carcinoma HeLa cells by stabilizing P53 .
23737080	0	Vitamin_C	0,9	SLC23A1	28,35	Vitamin C	SLC23A1	MESH:D001205	9963	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Vitamin_C transporter gene -LRB- SLC23A1 and SLC23A2 -RRB- polymorphisms , plasma vitamin_C levels , and gastric_cancer risk in the EPIC cohort .
11446766	0	Vitamin_C	0,9	SVCT2	81,86	Vitamin C	SVCT2	MESH:D001205	9962	Chemical	Gene	transport|amod|START_ENTITY transport|dep|evidence evidence|nmod|presence presence|nmod|END_ENTITY	Vitamin_C transport in human lens epithelial cells : evidence for the presence of SVCT2 .
19162177	0	Vitamin_C	0,9	SVCT2	73,78	Vitamin C	SVCT2	MESH:D001205	9962	Chemical	Gene	function|amod|START_ENTITY function|dep|role role|nmod|END_ENTITY	Vitamin_C function in the brain : vital role of the ascorbate transporter SVCT2 .
25014399	0	Vitamin_C	60,69	SVCT2	83,88	Vitamin C	SVCT2	MESH:D001205	9962	Chemical	Gene	Transporter|compound|START_ENTITY Transporter|appos|END_ENTITY	Functional Characterization and Molecular Identification of Vitamin_C Transporter -LRB- SVCT2 -RRB- in Human Corneal Epithelial -LRB- HCEC -RRB- and Retinal Pigment Epithelial -LRB- D407 -RRB- Cells .
25110615	0	Vitamin_C	0,9	SVCT2	82,87	Vitamin C	SVCT2	MESH:D001205	9962	Chemical	Gene	Transporters|compound|START_ENTITY Transporters|dep|END_ENTITY	Vitamin_C Transporters , Recycling and the Bystander Effect in the Nervous System : SVCT2 versus Gluts .
26921571	0	Vitamin_C	114,123	Somatostatin	51,63	Vitamin C	Somatostatin	MESH:D001205	6750	Chemical	Gene	sulfate|appos|START_ENTITY sulfate|compound|END_ENTITY	Congenital_fibrosarcoma in complete remission with Somatostatin , Bromocriptine , Retinoids , Vitamin_D3 , Vitamin_E , Vitamin_C , Melatonin , Calcium , Chondroitin sulfate associated with low doses of Cyclophosphamide in a 14-year Follow up .
21328462	0	Vitamin_C	0,9	VEGF	25,29	Vitamin C	VEGF	MESH:D001205	22339(Tax:10090)	Chemical	Gene	down-regulates|amod|START_ENTITY END_ENTITY|nsubj|down-regulates	Vitamin_C down-regulates VEGF production in B16F10 murine melanoma cells via the suppression of p42/44 MAPK activation .
21429301	0	Vitamin_C	0,9	p53	52,55	Vitamin C	p53	MESH:D001205	7157	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|apoptosis apoptosis|nmod|END_ENTITY	Vitamin_C increases the apoptosis via up-regulation p53 during cisplatin treatment in human colon_cancer cells .
25489444	0	Vitamin_D	10,19	C-reactive_Protein	39,57	Vitamin D	C-reactive Protein	MESH:D014807	1401	Chemical	Gene	Supplementation|compound|START_ENTITY Supplementation|nmod|END_ENTITY	Effect of Vitamin_D Supplementation on C-reactive_Protein in Patients with Nonalcoholic_Fatty_Liver .
20714323	0	Vitamin_D	0,9	CEACAM1	19,26	Vitamin D	CEACAM1	MESH:D014807	634	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Vitamin_D inhibits CEACAM1 to promote insulin/IGF-I _ receptor signaling without compromising anti-proliferative action .
24619416	0	Vitamin_D	0,9	COX-2	19,24	Vitamin D	COX-2	MESH:D014807	17709(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Vitamin_D inhibits COX-2 expression and inflammatory response by targeting thioesterase_superfamily_member_4 .
12039697	0	Vitamin_D	0,9	CYP1alpha	30,39	Vitamin D	CYP1alpha	MESH:D014807	1594	Chemical	Gene	START_ENTITY|dobj|polymorphism polymorphism|appos|END_ENTITY	Vitamin_D 1alpha-hydroxylase -LRB- CYP1alpha -RRB- polymorphism in Graves ' _ disease , Hashimoto 's _ thyroiditis_and_type_1_diabetes_mellitus .
20347976	0	Vitamin_D	0,9	CYP24	30,35	Vitamin D	CYP24	MESH:D014807	25279(Tax:10116)	Chemical	Gene	analogues|nsubj|START_ENTITY analogues|xcomp|targeting targeting|dobj|END_ENTITY	Vitamin_D analogues targeting CYP24 in chronic_kidney_disease .
25799416	0	Vitamin_D	0,9	Cdx-2	19,24	Vitamin D	Cdx-2	MESH:D014807	1045	Chemical	Gene	Polymorphism|compound|START_ENTITY Polymorphism|compound|END_ENTITY	Vitamin_D Receptor Cdx-2 Polymorphism and Premenopausal Breast Cancer Risk in Southern Pakistani Patients .
26287424	0	Vitamin_D	15,24	Cdx-2	34,39	Vitamin D	Cdx-2	MESH:D014807	1045	Chemical	Gene	Polymorphism|compound|START_ENTITY Polymorphism|compound|END_ENTITY	Association of Vitamin_D Receptor Cdx-2 Polymorphism With Cancer Risk : A Meta-Analysis .
26970179	0	Vitamin_D	22,31	Cdx-2	0,5	Vitamin D	Cdx-2	MESH:D014807	1045	Chemical	Gene	gene|compound|START_ENTITY polymorphism|nmod|gene polymorphism|amod|END_ENTITY	Cdx-2 polymorphism in Vitamin_D Receptor gene was associated with serum 25-hydroxyvitamin_D levels , bone_mineral_density and fracture in middle-aged and elderly Chinese women .
26280673	0	Vitamin_D	0,9	Cyclooxygenase_2	18,34	Vitamin D	Cyclooxygenase 2	MESH:D014807	5743	Chemical	Gene	Synthesis|compound|START_ENTITY Synthesis|compound|END_ENTITY	Vitamin_D Induces Cyclooxygenase_2 Dependent Prostaglandin_E2 Synthesis in HaCaT keratinocytes .
26280673	0	Vitamin_D	0,9	Cyclooxygenase_2	18,34	Vitamin D	Cyclooxygenase 2	MESH:D014807	5743	Chemical	Gene	Synthesis|compound|START_ENTITY Synthesis|compound|END_ENTITY	Vitamin_D Induces Cyclooxygenase_2 Dependent Prostaglandin_E2 Synthesis in HaCaT keratinocytes .
6894194	0	Vitamin_D	0,9	DBP	67,70	Vitamin D	DBP	MESH:D014807	1628	Chemical	Gene	transport|amod|START_ENTITY transport|dep|nature nature|nmod|interaction interaction|nmod|END_ENTITY	Vitamin_D transport - the nature of the interaction between plasma DBP and tissue protein .
26932723	0	Vitamin_D	0,9	Esr1	25,29	Vitamin D	Esr1	MESH:D014807	13982(Tax:10090)	Chemical	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Vitamin_D interacts with Esr1 and Igf1 to regulate molecular pathways relevant to Alzheimer 's _ disease .
15998839	0	Vitamin_D	0,9	FGF23	31,36	Vitamin D	FGF23	MESH:D014807	64654(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|actions actions|compound|END_ENTITY	Vitamin_D receptor-independent FGF23 actions in regulating phosphate and vitamin_D metabolism .
26180247	0	Vitamin_D	6,15	Insulin	55,62	Vitamin D	Insulin	MESH:D014807	3630	Chemical	Gene	Concentrations|compound|START_ENTITY Associated|nsubj|Concentrations Associated|nmod|Resistance Resistance|compound|END_ENTITY	Serum Vitamin_D Concentrations Are Not Associated with Insulin Resistance in Swiss Adults .
26317560	0	Vitamin_D	13,22	Insulin	54,61	Vitamin D	Insulin	MESH:D014807	3630	Chemical	Gene	START_ENTITY|dep|Role Role|nmod|Resistance Resistance|compound|END_ENTITY	Bioavailable Vitamin_D in Obese Children : The Role of Insulin Resistance .
26959059	0	Vitamin_D	35,44	Insulin	56,63	Vitamin D	Insulin	MESH:D014807	3630	Chemical	Gene	Action|nmod|START_ENTITY Action|nmod|Resistance Resistance|compound|END_ENTITY	The Potential Protective Action of Vitamin_D in Hepatic Insulin Resistance and Pancreatic Islet Dysfunction in Type_2_Diabetes_Mellitus .
20610636	0	Vitamin_D	0,9	LL-37	57,62	Vitamin D	LL-37	MESH:D014807	820	Chemical	Gene	status|amod|START_ENTITY status|appos|END_ENTITY	Vitamin_D status and antimicrobial peptide cathelicidin -LRB- LL-37 -RRB- concentrations in patients with active pulmonary_tuberculosis .
22301548	0	Vitamin_D	0,9	MAPK_phosphatase-1	88,106	Vitamin D	MAPK phosphatase-1	MESH:D014807	1843	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Vitamin_D inhibits monocyte/macrophage proinflammatory cytokine production by targeting MAPK_phosphatase-1 .
23149414	0	Vitamin_D	0,9	Mdm2	29,33	Vitamin D	Mdm2	MESH:D014807	17246(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Vitamin_D directly regulates Mdm2 gene expression in osteoblasts .
20385167	0	Vitamin_D	0,9	NF-kappaB	28,37	Vitamin D	NF-kappaB	MESH:D014807	4790	Chemical	Gene	modulate|nsubj|START_ENTITY modulate|dobj|activity activity|amod|END_ENTITY	Vitamin_D does not modulate NF-kappaB activity in Jurkat T cells .
25317198	0	Vitamin_D	0,9	Notch	36,41	Vitamin D	Notch	MESH:D014807	25496(Tax:10116)	Chemical	Gene	down-regulates|amod|START_ENTITY END_ENTITY|nsubj|down-regulates	Vitamin_D deficiency down-regulates Notch pathway contributing to skeletal_muscle_atrophy in old wistar_rats .
17204417	0	Vitamin_D	139,148	PTH	126,129	Vitamin D	PTH	MESH:D014807	5741	Chemical	Gene	metabolism|compound|START_ENTITY counter-balances|nmod|metabolism counter-balances|dobj|effects effects|nmod|END_ENTITY	Extracellular calcium is a direct effecter of VDR levels in proximal tubule epithelial cells that counter-balances effects of PTH on renal Vitamin_D metabolism .
24875346	0	Vitamin_D	28,37	Parathyroid_Hormone	116,135	Vitamin D	Parathyroid Hormone	MESH:D014807	5741	Chemical	Gene	Status|compound|START_ENTITY Associations|nmod|Status Associations|dep|Impact Impact|nmod|Status Status|compound|END_ENTITY	Prospective Associations of Vitamin_D Status With b-Cell Function , Insulin Sensitivity , and Glycemia : The Impact of Parathyroid_Hormone Status .
25923487	0	Vitamin_D	30,39	Parathyroid_Hormone	85,104	Vitamin D	Parathyroid Hormone	MESH:D014807	5741	Chemical	Gene	Yogurts|nmod|START_ENTITY Fortification|nmod|Yogurts Enhances|nsubj|Fortification Enhances|dobj|Inhibition Inhibition|nmod|END_ENTITY	Fortification of Yogurts with Vitamin_D and Calcium Enhances the Inhibition of Serum Parathyroid_Hormone and Bone Resorption Markers : A Double Blind Randomized Controlled Trial in Women over 60 Living in a Community Dwelling Home .
26858840	0	Vitamin_D	38,47	Parathyroid_Hormone	13,32	Vitamin D	Parathyroid Hormone	MESH:D014807	5741	Chemical	Gene	Supplementation|compound|START_ENTITY END_ENTITY|nmod|Supplementation	Reduction of Parathyroid_Hormone with Vitamin_D Supplementation in Blacks : A Randomized Controlled Trial .
26824280	0	Vitamin_D	10,19	Sclerostin	39,49	Vitamin D	Sclerostin	MESH:D014807	50964	Chemical	Gene	Treatment|compound|START_ENTITY Effect|nmod|Treatment Effect|nmod|Level Level|compound|END_ENTITY	Effect of Vitamin_D Treatment on Serum Sclerostin Level .
18096090	0	Vitamin_D	0,9	Sri	20,23	Vitamin D	Sri	MESH:D014807	6717	Chemical	Gene	status|amod|START_ENTITY status|nmod|END_ENTITY	Vitamin_D status in Sri Lankans living in Sri Lanka and Norway .
20359533	0	Vitamin_D	0,9	TACE	24,28	Vitamin D	TACE	MESH:D014807	6868	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Vitamin_D inhibition of TACE and prevention of renal_osteodystrophy and cardiovascular_mortality .
25134788	0	Vitamin_D	0,9	TGF-b	33,38	Vitamin D	TGF-b	MESH:D014807	7040	Chemical	Gene	counteracts|nsubj|START_ENTITY counteracts|dobj|END_ENTITY	Vitamin_D counteracts fibrogenic TGF-b signalling in human hepatic stellate cells both receptor-dependently and independently .
25929726	0	Vitamin_D	0,9	TNF-a	38,43	Vitamin D	TNF-a	MESH:D014807	24835(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|amod|END_ENTITY	Vitamin_D attenuates pro-inflammatory TNF-a cytokine expression by inhibiting NF - B/p65 signaling in hypertrophied rat hearts .
12566470	0	Vitamin_D	0,9	VDR	20,23	Vitamin D	VDR	MESH:D014807	22337(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Vitamin_D receptor -LRB- VDR -RRB- knockout mice reveal VDR-independent regulation of intestinal calcium absorption and ECaC2 and calbindin_D9k mRNA .
17204417	0	Vitamin_D	139,148	VDR	46,49	Vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	metabolism|compound|START_ENTITY counter-balances|nmod|metabolism cells|acl:relcl|counter-balances effecter|nmod|cells effecter|nmod|levels levels|compound|END_ENTITY	Extracellular calcium is a direct effecter of VDR levels in proximal tubule epithelial cells that counter-balances effects of PTH on renal Vitamin_D metabolism .
18709640	0	Vitamin_D	155,164	VDR	189,192	Vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	intake|compound|START_ENTITY intake|acl|mediated mediated|nmod|binding binding|compound|END_ENTITY	Modification of the inverse association between dietary vitamin_D intake and colorectal_cancer risk by a FokI variant supports a chemoprotective action of Vitamin_D intake mediated through VDR binding .
20831823	0	Vitamin_D	15,24	VDR	100,103	Vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	pathways|compound|START_ENTITY Alterations|nmod|pathways Alterations|dep|study study|nmod|expression expression|compound|END_ENTITY	Alterations in Vitamin_D signalling and metabolic pathways in breast_cancer progression : a study of VDR , CYP27B1 and CYP24A1 expression in benign and malignant breast lesions .
20920864	0	Vitamin_D	0,9	VDR	20,23	Vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	Receptor|compound|START_ENTITY Receptor|appos|END_ENTITY	Vitamin_D Receptor -LRB- VDR -RRB- polymorphic variants in patients with cancer and Gaucher_disease .
21664963	0	Vitamin_D	0,9	VDR	20,23	Vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	receptor|amod|START_ENTITY influence|nsubj|receptor influence|dep|END_ENTITY	Vitamin_D receptor -LRB- VDR -RRB- gene SNPs influence VDR expression and modulate protection from multiple_sclerosis in HLA-DRB1 * 15-positive individuals .
21664963	0	Vitamin_D	0,9	VDR	45,48	Vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	receptor|amod|START_ENTITY influence|nsubj|receptor influence|dobj|expression expression|compound|END_ENTITY	Vitamin_D receptor -LRB- VDR -RRB- gene SNPs influence VDR expression and modulate protection from multiple_sclerosis in HLA-DRB1 * 15-positive individuals .
22537547	0	Vitamin_D	0,9	VDR	49,52	Vitamin D	VDR	MESH:D014807	22337(Tax:10090)	Chemical	Gene	deficiency|amod|START_ENTITY decreases|nsubj|deficiency decreases|dobj|expression expression|nmod|END_ENTITY	Vitamin_D deficiency decreases the expression of VDR and prohibitin in the lungs of mice with allergic_airway_inflammation .
22692397	0	Vitamin_D	0,9	VDR	31,34	Vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Vitamin_D and polymorphisms of VDR gene in patients with systemic_lupus_erythematosus .
23858619	0	Vitamin_D	0,9	VDR	31,34	Vitamin D	VDR	MESH:D014807	22337(Tax:10090)	Chemical	Gene	action|amod|START_ENTITY action|dep|lessons lessons|nmod|END_ENTITY	Vitamin_D action : lessons from VDR and Cyp27b1 null mice .
24019226	0	Vitamin_D	0,9	VDR	20,23	Vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	polymorphisms|amod|START_ENTITY polymorphisms|appos|END_ENTITY	Vitamin_D receptor -LRB- VDR -RRB- polymorphisms and severe RSV bronchiolitis : a systematic review and meta-analysis .
25813397	0	Vitamin_D	0,9	VDR	10,13	Vitamin D	VDR	MESH:D014807	22337(Tax:10090)	Chemical	Gene	START_ENTITY|parataxis|ameliorates ameliorates|nsubj|signaling signaling|compound|END_ENTITY	Vitamin_D / VDR signaling pathway ameliorates 2,4,6-trinitrobenzene _ sulfonic_acid-induced colitis by inhibiting intestinal epithelial apoptosis .
25890006	0	Vitamin_D	55,64	VDR	75,78	Vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association of Taq I , Fok I and Apa I polymorphisms in Vitamin_D Receptor -LRB- VDR -RRB- gene with Leprosy .
25890006	0	Vitamin_D	55,64	VDR	75,78	Vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association of Taq I , Fok I and Apa I polymorphisms in Vitamin_D Receptor -LRB- VDR -RRB- gene with Leprosy .
26153579	0	Vitamin_D	0,9	VDR	20,23	Vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Vitamin_D receptor -LRB- VDR -RRB- genetic polymorphisms associated with intervertebral_disc_degeneration .
26171337	0	Vitamin_D	0,9	VDR	20,23	Vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	Polymorphisms|compound|START_ENTITY Polymorphisms|appos|END_ENTITY	Vitamin_D Receptor -LRB- VDR -RRB- Polymorphisms and Late-Onset Alzheimer 's _ Disease : An Association Study .
26211511	0	Vitamin_D	65,74	VDR	85,88	Vitamin D	VDR	MESH:D014807	22337(Tax:10090)	Chemical	Gene	Receptor|compound|START_ENTITY Receptor|appos|END_ENTITY	Compensatory Changes in Calcium Metabolism Accompany the Loss of Vitamin_D Receptor -LRB- VDR -RRB- From the Distal Intestine and Kidney of Mice .
26441239	0	Vitamin_D	87,96	VDR	161,164	Vitamin D	VDR	MESH:D014807	22337(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|Profiles Profiles|nmod|Mice Mice|compound|END_ENTITY	A High-Calcium and Phosphate Rescue Diet and VDR-Expressing Transgenes Normalize Serum Vitamin_D Metabolite Profiles and Renal Cyp27b1 and Cyp24a1 Expression in VDR Null Mice .
26501255	0	Vitamin_D	14,23	VDR	34,37	Vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	Positively|compound|START_ENTITY Positively|appos|END_ENTITY	Expression of Vitamin_D Receptor -LRB- VDR -RRB- Positively Correlates with Survival of Urothelial Bladder Cancer Patients .
26675943	0	Vitamin_D	0,9	VDR	10,13	Vitamin D	VDR	MESH:D014807	22337(Tax:10090)	Chemical	Gene	lipopolysaccharide|compound|START_ENTITY lipopolysaccharide|compound|END_ENTITY	Vitamin_D / VDR signaling attenuates lipopolysaccharide - induced acute_lung_injury by maintaining the integrity of the pulmonary epithelial barrier .
26902087	0	Vitamin_D	34,43	VDR	54,57	Vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	Receptor|compound|START_ENTITY Receptor|appos|END_ENTITY	Quercetin Directly Interacts with Vitamin_D Receptor -LRB- VDR -RRB- : Structural Implication of VDR Activation by Quercetin .
26902087	0	Vitamin_D	34,43	VDR	86,89	Vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	Receptor|compound|START_ENTITY Interacts|nmod|Receptor Interacts|dep|Implication Implication|nmod|Activation Activation|compound|END_ENTITY	Quercetin Directly Interacts with Vitamin_D Receptor -LRB- VDR -RRB- : Structural Implication of VDR Activation by Quercetin .
26945790	0	Vitamin_D	77,86	VDR	97,100	Vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	Receptor|compound|START_ENTITY Receptor|appos|END_ENTITY	The binding mode prediction and similar ligand potency in the active site of Vitamin_D Receptor -LRB- VDR -RRB- with QM/MM interaction , MESP and MD simulation .
27065588	0	Vitamin_D	0,9	VDR	20,23	Vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	Receptor|compound|START_ENTITY Receptor|appos|END_ENTITY	Vitamin_D Receptor -LRB- VDR -RRB- Gene Polymorphisms -LRB- FokI , BsmI -RRB- and their Relation to Vitamin_D Status in Pediatrics_beta_Thalassemia Major .
15225770	0	Vitamin_D	53,62	Vitamin_D_receptor	0,18	Vitamin D	Vitamin D receptor	MESH:D014807	7421	Chemical	Gene	polymorphisms|xcomp|START_ENTITY polymorphisms|nsubj|gene gene|amod|END_ENTITY	Vitamin_D_receptor gene polymorphisms in relation to Vitamin_D related disease states .
15225763	0	Vitamin_D	14,23	cyp24	41,46	Vitamin D	cyp24	MESH:D014807	13081(Tax:10090)	Chemical	Gene	Insights|nmod|START_ENTITY metabolism|nsubj|Insights metabolism|xcomp|using using|dobj|over-expression over-expression|amod|END_ENTITY	Insights into Vitamin_D metabolism using cyp24 over-expression and knockout systems in conjunction with liquid chromatography/mass spectrometry -LRB- LC/MS -RRB- .
17207766	0	Vitamin_D	90,99	cytochrome_P450C24A1	52,72	Vitamin D	cytochrome P450C24A1	MESH:D014807	25279(Tax:10116)	Chemical	Gene	pathway|compound|START_ENTITY END_ENTITY|nmod|pathway	Hybrid homology modeling and mutational analysis of cytochrome_P450C24A1 -LRB- CYP24A1 -RRB- of the Vitamin_D pathway : insights into substrate specificity and membrane bound structure-function .
15671080	0	Vitamin_D	0,9	fibroblast_growth_factor-23	33,60	Vitamin D	fibroblast growth factor-23	MESH:D014807	8074	Chemical	Gene	START_ENTITY|dep|regulate regulate|xcomp|END_ENTITY	Vitamin_D and phosphate regulate fibroblast_growth_factor-23 in K-562 cells .
17213855	0	Vitamin_D	0,9	insulin	11,18	Vitamin D	insulin	MESH:D014807	3630	Chemical	Gene	START_ENTITY|appos|resistance resistance|compound|END_ENTITY	Vitamin_D , insulin resistance , and renal_disease .
18187309	0	Vitamin_D	0,9	insulin	20,27	Vitamin D	insulin	MESH:D014807	3630	Chemical	Gene	_|advcl|START_ENTITY _|nsubj|glucose glucose|appos|END_ENTITY	Vitamin_D , glucose , _ insulin , _ and_insulin_sensitivity .
19555519	0	Vitamin_D	0,9	insulin	33,40	Vitamin D	insulin	MESH:D014807	3630	Chemical	Gene	START_ENTITY|dep|roles roles|nmod|sensitivity sensitivity|compound|END_ENTITY	Vitamin_D : emerging new roles in insulin sensitivity .
19781131	0	Vitamin_D	0,9	insulin	104,111	Vitamin D	insulin	MESH:D014807	3630	Chemical	Gene	supplementation|amod|START_ENTITY reduces|nsubj|supplementation reduces|nmod|women women|acl|living living|nmod|Zealand Zealand|acl:relcl|END_ENTITY	Vitamin_D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin_D deficient - a randomised , placebo-controlled trial .
19781131	0	Vitamin_D	0,9	insulin	34,41	Vitamin D	insulin	MESH:D014807	3630	Chemical	Gene	supplementation|amod|START_ENTITY reduces|nsubj|supplementation reduces|dobj|resistance resistance|compound|END_ENTITY	Vitamin_D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin_D deficient - a randomised , placebo-controlled trial .
21712836	0	Vitamin_D	0,9	insulin	37,44	Vitamin D	insulin	MESH:D014807	3630	Chemical	Gene	hormone|amod|START_ENTITY hormone|nmod|resistance resistance|compound|END_ENTITY	Vitamin_D and parathyroid hormone in insulin resistance of abdominal_obesity : cause or effect ?
22464806	0	Vitamin_D	0,9	insulin	43,50	Vitamin D	insulin	MESH:D014807	3630	Chemical	Gene	supplementation|amod|START_ENTITY has|nsubj|supplementation has|dobj|effect effect|nmod|assessment assessment|compound|END_ENTITY	Vitamin_D supplementation has no effect on insulin resistance assessment in women with polycystic_ovary_syndrome and vitamin_D_deficiency .
23158978	0	Vitamin_D	0,9	insulin	28,35	Vitamin D	insulin	MESH:D014807	3630	Chemical	Gene	START_ENTITY|nmod|predictor predictor|nmod|resistance resistance|compound|END_ENTITY	Vitamin_D as a predictor of insulin resistance in polycystic_ovarian_syndrome .
26101151	0	Vitamin_D	0,9	insulin	33,40	Vitamin D	insulin	MESH:D014807	3630	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	Vitamin_D intake associates with insulin resistance in type 2 diabetes , but not in latent_autoimmune_diabetes_in_adults .
9799895	0	Vitamin_D	0,9	insulin	59,66	Vitamin D	insulin	MESH:D014807	3630	Chemical	Gene	replacement|amod|START_ENTITY increase|nsubj|replacement increase|dobj|resistance resistance|compound|END_ENTITY	Vitamin_D replacement in Asians with diabetes may increase insulin resistance .
23083515	0	Vitamin_D	0,9	interleukin-8	37,50	Vitamin D	interleukin-8	MESH:D014807	3576	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Vitamin_D inhibits the expression of interleukin-8 in human periodontal ligament cells stimulated with Porphyromonas_gingivalis .
10873663	0	Vitamin_D	0,9	keratinocyte_growth_factor	35,61	Vitamin D	keratinocyte growth factor	MESH:D014807	2252	Chemical	Gene	up-regulation|amod|START_ENTITY up-regulation|nmod|END_ENTITY	Vitamin_D induced up-regulation of keratinocyte_growth_factor -LRB- FGF-7 / KGF -RRB- in MCF-7 human breast_cancer cells .
3873510	0	Vitamin_D	0,9	osteocalcin	31,42	Vitamin D	osteocalcin	MESH:D014807	81613(Tax:10116)	Chemical	Gene	metabolites|nsubj|START_ENTITY metabolites|xcomp|regulate regulate|dobj|synthesis synthesis|compound|END_ENTITY	Vitamin_D metabolites regulate osteocalcin synthesis and proliferation of human bone cells in vitro .
15551058	0	Vitamin_D	0,9	parathyroid_hormone	75,94	Vitamin D	parathyroid hormone	MESH:D014807	5741	Chemical	Gene	status|amod|START_ENTITY status|nmod|factor factor|acl|determining determining|dobj|levels levels|nmod|END_ENTITY	Vitamin_D status as the major factor determining the circulating levels of parathyroid_hormone : a study in normal subjects .
17965037	0	Vitamin_D	0,9	parathyroid_hormone	47,66	Vitamin D	parathyroid hormone	MESH:D014807	5741	Chemical	Gene	supplementation|amod|START_ENTITY has|nsubj|supplementation has|dobj|effects effects|nmod|markers markers|compound|END_ENTITY	Vitamin_D supplementation has minor effects on parathyroid_hormone and bone turnover markers in vitamin_D-deficient bedridden older patients .
19098950	0	Vitamin_D	0,9	parathyroid_hormone	86,105	Vitamin D	parathyroid hormone	MESH:D014807	5741	Chemical	Gene	insufficiency|amod|START_ENTITY associated|nsubjpass|insufficiency associated|nmod|concentrations concentrations|compound|END_ENTITY	Vitamin_D insufficiency in New Zealanders during the winter is associated with higher parathyroid_hormone concentrations : implications for bone health ?
20175051	0	Vitamin_D	0,9	parathyroid_hormone	70,89	Vitamin D	parathyroid hormone	MESH:D014807	5741	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|patients patients|nmod|levels levels|nmod|END_ENTITY	Vitamin_D treatment in hemodialysis patients with low serum levels of parathyroid_hormone : which is the best choice ?
21956833	0	Vitamin_D	0,9	parathyroid_hormone	80,99	Vitamin D	parathyroid hormone	MESH:D014807	5741	Chemical	Gene	insufficiency|amod|START_ENTITY associated|nsubjpass|insufficiency associated|nmod|END_ENTITY	Vitamin_D insufficiency is prevalent and vitamin_D is inversely associated with parathyroid_hormone and calcitriol in pregnant adolescents .
4038405	0	Vitamin_D	0,9	parathyroid_hormone	94,113	Vitamin D	parathyroid hormone	MESH:D014807	396436(Tax:9031)	Chemical	Gene	status|amod|START_ENTITY regulates|nsubj|status regulates|xcomp|END_ENTITY	Vitamin_D status regulates 25-hydroxyvitamin_D3-1 alpha-hydroxylase and its responsiveness to parathyroid_hormone in the chick .
12746312	0	Vitamin_D	0,9	regulator_of_G_protein_signaling-2	75,109	Vitamin D	regulator of G protein signaling-2	MESH:D014807	84583(Tax:10116)	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|amod|END_ENTITY	Vitamin_D and dexamethasone inversely regulate parathyroid hormone-induced regulator_of_G_protein_signaling-2 expression in osteoblast-like cells .
23926179	0	Vitamin_D	0,9	renin	27,32	Vitamin D	renin	MESH:D014807	5972	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|activity activity|compound|END_ENTITY	Vitamin_D increases plasma renin activity independently of plasma Ca2 + via hypovolemia and b-adrenergic activity .
24619416	0	Vitamin_D	0,9	thioesterase_superfamily_member_4	75,108	Vitamin D	thioesterase superfamily member 4	MESH:D014807	75778(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Vitamin_D inhibits COX-2 expression and inflammatory response by targeting thioesterase_superfamily_member_4 .
2246328	0	Vitamin_D	0,9	transferrin	20,31	Vitamin D	transferrin	MESH:D014807	7018	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Vitamin_D regulates transferrin receptor expression by bone marrow macrophage precursors .
19931390	0	Vitamin_D	0,9	transforming_growth_factor_beta1	48,80	Vitamin D	transforming growth factor beta1	MESH:D014807	7040	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Vitamin_D inhibition of pro-fibrotic effects of transforming_growth_factor_beta1 in lung fibroblasts and epithelial cells .
25962507	0	Vitamin_D	0,9	vitamin_D_binding_protein	11,36	Vitamin D	vitamin D binding protein	MESH:D014807	2638	Chemical	Gene	START_ENTITY|appos|polymorphisms polymorphisms|amod|END_ENTITY	Vitamin_D , vitamin_D_binding_protein gene polymorphisms , race and risk of incident stroke : the Atherosclerosis Risk in Communities -LRB- ARIC -RRB- study .
10342883	0	Vitamin_D	0,9	vitamin_D_receptor	129,147	Vitamin D	vitamin D receptor	MESH:D014807	24873(Tax:10116)	Chemical	Gene	represses|nsubj|START_ENTITY represses|parataxis|required required|nsubjpass|domain domain|nmod|END_ENTITY	Vitamin_D represses retinoic_acid-dependent transactivation of the retinoic_acid receptor-beta2 promoter : the AF-2 domain of the vitamin_D_receptor is required for transrepression .
15225775	0	Vitamin_D	43,52	vitamin_D_receptor	89,107	Vitamin D	vitamin D receptor	MESH:D014807	24873(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY compounds|nsubj|regulation compounds|nmod|absence absence|nmod|END_ENTITY	Breast_cancer cell regulation by high-dose Vitamin_D compounds in the absence of nuclear vitamin_D_receptor .
16374421	0	Vitamin_D	0,9	vitamin_D_receptor	67,85	Vitamin D	vitamin D receptor	MESH:D014807	7421	Chemical	Gene	START_ENTITY|dep|role role|nmod|activation activation|compound|END_ENTITY	Vitamin_D in chronic_kidney_disease : a systemic role for selective vitamin_D_receptor activation .
18694980	0	Vitamin_D	0,9	vitamin_D_receptor	41,59	Vitamin D	vitamin D receptor	MESH:D014807	7421	Chemical	Gene	health|amod|START_ENTITY health|dep|lessons lessons|nmod|mice mice|compound|END_ENTITY	Vitamin_D and human health : lessons from vitamin_D_receptor null mice .
21755299	0	Vitamin_D	0,9	vitamin_D_receptor	35,53	Vitamin D	vitamin D receptor	MESH:D014807	7421	Chemical	Gene	status|amod|START_ENTITY status|nmod|END_ENTITY	Vitamin_D status and expression of vitamin_D_receptor and LL-37 in patients with spontaneous_bacterial_peritonitis .
21764620	0	Vitamin_D	0,9	vitamin_D_receptor	22,40	Vitamin D	vitamin D receptor	MESH:D014807	7421	Chemical	Gene	START_ENTITY|dobj|polymorphisms polymorphisms|dep|END_ENTITY	Vitamin_D deficiency , vitamin_D_receptor gene polymorphisms and cardiovascular risk factors in Caribbean patients with type_2_diabetes .
22681928	0	Vitamin_D	0,9	vitamin_D_receptor	108,126	Vitamin D	vitamin D receptor	MESH:D014807	7421	Chemical	Gene	deficiency|amod|START_ENTITY deficiency|dep|study study|nmod|variants variants|compound|END_ENTITY	Vitamin_D deficiency in girls from South Brazil : a cross-sectional study on prevalence and association with vitamin_D_receptor gene variants .
22763025	0	Vitamin_D	1,10	vitamin_D_receptor	86,104	Vitamin D	vitamin D receptor	MESH:D014807	7421	Chemical	Gene	system|compound|START_ENTITY system|dep|lessons lessons|nmod|activators activators|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Vitamin_D hormone system and diabetes_mellitus : lessons from selective activators of vitamin_D_receptor and diabetes_mellitus -RSB- .
23256830	0	Vitamin_D	1,10	vitamin_D_receptor	72,90	Vitamin D	vitamin D receptor	MESH:D014807	7421	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	-LSB- Vitamin_D metabolism and current options for therapeutic activation of vitamin_D_receptor in patients with chronic_kidney_disease or renal_failure -RSB- .
24792400	0	Vitamin_D	0,9	vitamin_D_receptor	27,45	Vitamin D	vitamin D receptor	MESH:D014807	7421	Chemical	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|END_ENTITY	Vitamin_D up-regulates the vitamin_D_receptor by protecting it from proteasomal_degradation in human CD4 + T cells .
25016144	0	Vitamin_D	0,9	vitamin_D_receptor	122,140	Vitamin D	vitamin D receptor	MESH:D014807	7421	Chemical	Gene	supplementation|amod|START_ENTITY promotes|nsubj|supplementation promotes|nmod|expression expression|compound|END_ENTITY	Vitamin_D supplementation promotes macrophages ' anti-mycobacterial activity in type_2_diabetes_mellitus patients with low vitamin_D_receptor expression .
27041576	0	Vitamin_D	0,9	vitamin_D_receptor	10,28	Vitamin D	vitamin D receptor	MESH:D014807	7421	Chemical	Gene	START_ENTITY|parataxis|regulates regulates|nsubj|axis axis|compound|END_ENTITY	Vitamin_D / vitamin_D_receptor axis regulates DNA repair during oncogene-induced_senescence .
25628655	0	Vitamin_D3	26,36	CYP27A1	52,59	Vitamin D3	CYP27A1	MESH:D002762	1593	Chemical	Gene	Polymorphism|compound|START_ENTITY Polymorphism|compound|END_ENTITY	The Associations of Novel Vitamin_D3 Metabolic Gene CYP27A1 Polymorphism , Adiponectin/Leptin Ratio , and Metabolic_Syndrome in Middle-Aged Taiwanese Males .
8816911	0	Vitamin_D3	0,10	MMP-3	40,45	Vitamin D3	MMP-3	MESH:D002762	171045(Tax:10116)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Vitamin_D3 regulation of stromelysin-1 -LRB- MMP-3 -RRB- in chondrocyte cultures is mediated by protein_kinase_C .
26921571	0	Vitamin_D3	91,101	Somatostatin	51,63	Vitamin D3	Somatostatin	MESH:D002762	6750	Chemical	Gene	sulfate|appos|START_ENTITY sulfate|compound|END_ENTITY	Congenital_fibrosarcoma in complete remission with Somatostatin , Bromocriptine , Retinoids , Vitamin_D3 , Vitamin_E , Vitamin_C , Melatonin , Calcium , Chondroitin sulfate associated with low doses of Cyclophosphamide in a 14-year Follow up .
26770399	0	Vitamin_D3	0,10	Toll-like_receptor_4	18,38	Vitamin D3	Toll-like receptor 4	MESH:D002762	7099	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|END_ENTITY	Vitamin_D3 alters Toll-like_receptor_4 signaling in monocytes of pregnant women at risk for preeclampsia .
10424403	0	Vitamin_D3	0,10	VDR	21,24	Vitamin D3	VDR	MESH:D002762	22337(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Vitamin_D3 receptor -LRB- VDR -RRB- expression in HC-11 mammary cells : regulation by growth-modulatory agents , differentiation , and Ha-ras transformation .
15225755	0	Vitamin_D3	55,65	VDR	40,43	Vitamin D3	VDR	MESH:D002762	7421	Chemical	Gene	analogs|amod|START_ENTITY bound|nmod|analogs bound|nsubj|Model Model|nmod|structure structure|nmod|END_ENTITY	Model of three-dimensional structure of VDR bound with Vitamin_D3 analogs substituted at carbon-2 .
16483768	0	Vitamin_D3	14,24	VDR	45,48	Vitamin D3	VDR	MESH:D002762	7421	Chemical	Gene	metabolism|amod|START_ENTITY Inhibition|nmod|metabolism enhances|nsubj|Inhibition enhances|dobj|END_ENTITY	Inhibition of Vitamin_D3 metabolism enhances VDR signalling in androgen-independent prostate_cancer cells .
23840333	0	Vitamin_D3	0,10	VDR	22,25	Vitamin D3	VDR	MESH:D002762	7421	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Vitamin_D3 receptor -LRB- VDR -RRB- gene rs2228570 -LRB- Fok1 -RRB- and rs731236 -LRB- Taq1 -RRB- variants are not associated with the risk for multiple_sclerosis : results of a new study and a meta-analysis .
25827670	0	Vitamin_D3	184,194	VDR	79,82	Vitamin D3	VDR	MESH:D002762	7421	Chemical	Gene	megadose|amod|START_ENTITY reduces|nsubj|megadose Effect|parataxis|reduces Effect|nmod|polymorphism polymorphism|nmod|gene gene|compound|END_ENTITY	Effect of vitamin_D3 supplementation and influence of BsmI polymorphism of the VDR gene of the inflammatory profile and oxidative stress in elderly women with vitamin_D insufficiency : Vitamin_D3 megadose reduces inflammatory markers .
12553030	0	Vitamin_D3	0,10	VDUP1	35,40	Vitamin D3	VDUP1	MESH:D002762	10628	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Vitamin_D3 up-regulated protein 1 -LRB- VDUP1 -RRB- expression in gastrointestinal_cancer and its relation to stage of disease .
17040494	0	Vitamin_D3	0,10	VDUP1	34,39	Vitamin D3	VDUP1	MESH:D002762	10628	Chemical	Gene	upregulated|nsubj|START_ENTITY upregulated|ccomp|regulator regulator|nsubj|protein protein|appos|END_ENTITY	Vitamin_D3 upregulated protein 1 -LRB- VDUP1 -RRB- is a regulator for redox signaling and stress-mediated diseases .
20656682	0	Vitamin_D3	0,10	VDUP1	34,39	Vitamin D3	VDUP1	MESH:D002762	10628	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Vitamin_D3 up-regulated protein 1 -LRB- VDUP1 -RRB- is regulated by FOXO3A and miR-17-5p at the transcriptional and post-transcriptional levels , respectively , in senescent fibroblasts .
15331408	0	Vitamin_D3	0,10	caspase-14	19,29	Vitamin D3	caspase-14	MESH:D002762	23581	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Vitamin_D3 induces caspase-14 expression in psoriatic_lesions and enhances caspase-14 processing in organotypic skin cultures .
1924312	0	Vitamin_D3	0,10	group-specific_component	28,52	Vitamin D3	group-specific component	MESH:D002762	14473(Tax:10090)	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Vitamin_D3 binding protein -LRB- group-specific_component -RRB- is a precursor for the macrophage-activating signal factor from lysophosphatidylcholine-treated lymphocytes .
15059636	0	Vitamin_E	0,9	C-reactive_protein	24,42	Vitamin E	C-reactive protein	MESH:D014810	1401	Chemical	Gene	modulation|amod|START_ENTITY modulation|nmod|END_ENTITY	Vitamin_E modulation of C-reactive_protein in smokers with acute_coronary_syndromes .
10880419	0	Vitamin_E	0,9	CD36	59,63	Vitamin E	CD36	MESH:D014810	948	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|advcl|inhibiting inhibiting|dobj|expression expression|compound|END_ENTITY	Vitamin_E reduces the uptake of oxidized LDL by inhibiting CD36 scavenger receptor expression in cultured aortic smooth muscle cells .
15979077	0	Vitamin_E	0,9	CD36	19,23	Vitamin E	CD36	MESH:D014810	100008825(Tax:9986)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Vitamin_E inhibits CD36 scavenger receptor expression in hypercholesterolemic rabbits .
11213082	0	Vitamin_E	0,9	COX_II	44,50	Vitamin E	COX II	MESH:D014810	26198(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Vitamin_E inhibits renal mRNA expression of COX_II , HO I , TGFbeta , and osteopontin in the rat model of cyclosporine nephrotoxicity .
15225641	0	Vitamin_E	0,9	CRABP-II	20,28	Vitamin E	CRABP-II	MESH:D014810	1382	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|amod|END_ENTITY	Vitamin_E activates CRABP-II gene expression in cultured human fibroblasts , role of protein_kinase_C .
12207324	0	Vitamin_E	0,9	IL-4	19,23	Vitamin E	IL-4	MESH:D014810	3565	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Vitamin_E inhibits IL-4 gene expression in peripheral blood T cells .
22281490	0	Vitamin_E	0,9	MIF	15,18	Vitamin E	MIF	MESH:D014810	4282	Chemical	Gene	Inhibitor|nsubj|START_ENTITY Inhibitor|compound|END_ENTITY	Vitamin_E is a MIF Inhibitor .
20205474	0	Vitamin_E	0,9	P-glycoprotein	15,29	Vitamin E	P-glycoprotein	MESH:D014810	5243	Chemical	Gene	mechanism|compound|START_ENTITY mechanism|compound|END_ENTITY	Vitamin_E TPGS P-glycoprotein inhibition mechanism : influence on conformational flexibility , intracellular ATP levels , and role of time and site of access .
22013196	0	Vitamin_E	0,9	PUFA	42,46	Vitamin E	PUFA	MESH:D014810	394185(Tax:7955)	Chemical	Gene	deficiency|amod|START_ENTITY decreases|nsubj|deficiency decreases|dobj|END_ENTITY	Vitamin_E deficiency decreases long-chain PUFA in zebrafish -LRB- Danio_rerio -RRB- .
26291567	0	Vitamin_E	0,9	PUFA	51,55	Vitamin E	PUFA	MESH:D014810	9933	Chemical	Gene	START_ENTITY|nmod|relation relation|nmod|END_ENTITY	Vitamin_E function and requirements in relation to PUFA .
26886716	0	Vitamin_E	0,9	Paraoxonase-1	25,38	Vitamin E	Paraoxonase-1	MESH:D014810	5444	Chemical	Gene	Activity|compound|START_ENTITY Activity|compound|END_ENTITY	Vitamin_E Improves Serum Paraoxonase-1 Activity and Some Metabolic Factors in Patients with Type 2 Diabetes : No Effects on Nitrite/Nitrate Levels .
26921571	0	Vitamin_E	103,112	Somatostatin	51,63	Vitamin E	Somatostatin	MESH:D014810	6750	Chemical	Gene	sulfate|appos|START_ENTITY sulfate|compound|END_ENTITY	Congenital_fibrosarcoma in complete remission with Somatostatin , Bromocriptine , Retinoids , Vitamin_D3 , Vitamin_E , Vitamin_C , Melatonin , Calcium , Chondroitin sulfate associated with low doses of Cyclophosphamide in a 14-year Follow up .
20153623	0	Vitamin_E	0,9	aryl_hydrocarbon_receptor	50,75	Vitamin E	aryl hydrocarbon receptor	MESH:D014810	11622(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|compound|END_ENTITY	Vitamin_E status and metabolism in adult and aged aryl_hydrocarbon_receptor null mice .
16012341	0	Vitamin_E	0,9	cyclooxygenase-2	57,73	Vitamin E	cyclooxygenase-2	MESH:D014810	19225(Tax:10090)	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|advcl|repressing repressing|dobj|activity activity|amod|END_ENTITY	Vitamin_E prevents the neuronal cell death by repressing cyclooxygenase-2 activity .
16046707	0	Vitamin_E	0,9	cyclooxygenase-2	120,136	Vitamin E	cyclooxygenase-2	MESH:D014810	5743	Chemical	Gene	increases|nsubj|START_ENTITY increases|advcl|opposing opposing|nmod|END_ENTITY	Vitamin_E increases production of vasodilator prostanoids in human aortic endothelial cells through opposing effects on cyclooxygenase-2 and phospholipase_A2 .
10502120	0	Vitamin_E	0,9	focal_segmental_glomerulosclerosis	23,57	Vitamin E	focal segmental glomerulosclerosis	MESH:D014810	81	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|END_ENTITY	Vitamin_E treatment of focal_segmental_glomerulosclerosis : results of an open-label study .
8108035	0	Vitamin_E	0,9	insulin	33,40	Vitamin E	insulin	MESH:D014810	3630	Chemical	Gene	improves|nsubj|START_ENTITY improves|dobj|action action|nmod|END_ENTITY	Vitamin_E improves the action of insulin .
12876296	0	Vitamin_E	0,9	luteinizing_hormone-releasing_hormone	21,58	Vitamin E	luteinizing hormone-releasing hormone	MESH:D014810	25194(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|amod|END_ENTITY	Vitamin_E stimulates luteinizing_hormone-releasing_hormone and ascorbic_acid release from medial basal hypothalami of adult male rats .
3707988	0	Vitamin_E	0,9	platelet_phospholipase_A2	19,44	Vitamin E	platelet phospholipase A2	MESH:D014810	29692(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Vitamin_E inhibits platelet_phospholipase_A2 .
17449172	0	Vitamin_E_succinate	0,19	mda-7	40,45	Vitamin E succinate	mda-7	null	11009	Chemical	Gene	START_ENTITY|nmod|results results|amod|END_ENTITY	Vitamin_E_succinate in combination with mda-7 results in enhanced human ovarian_tumor cell killing through modulation of extrinsic and intrinsic apoptotic pathways .
23391196	0	Vitamin_K	218,227	Factor_Xa	183,192	Vitamin K	Factor Xa	MESH:D014812	2159	Chemical	Gene	Antagonism|compound|START_ENTITY Inhibition|nmod|Antagonism Inhibition|compound|END_ENTITY	Outcomes of discontinuing rivaroxaban compared with warfarin in patients with nonvalvular atrial_fibrillation : analysis from the ROCKET AF trial -LRB- Rivaroxaban Once-Daily , Oral , Direct Factor_Xa Inhibition Compared With Vitamin_K Antagonism for Prevention of Stroke and Embolism Trial in Atrial_Fibrillation -RRB- .
25749644	0	Vitamin_K	188,197	Factor_Xa	153,162	Vitamin K	Factor Xa	MESH:D014812	2159	Chemical	Gene	Antagonism|compound|START_ENTITY Inhibition|nmod|Antagonism Inhibition|compound|END_ENTITY	Digoxin use in patients with atrial_fibrillation and adverse cardiovascular outcomes : a retrospective analysis of the Rivaroxaban Once Daily Oral Direct Factor_Xa Inhibition Compared with Vitamin_K Antagonism for Prevention of Stroke and Embolism Trial in Atrial_Fibrillation -LRB- ROCKET AF -RRB- .
26386791	0	Vitamin_K	174,183	Factor_Xa	139,148	Vitamin K	Factor Xa	MESH:D014812	2159	Chemical	Gene	Antagonism|compound|START_ENTITY Inhibition|nmod|Antagonism Inhibition|compound|END_ENTITY	Efficacy and safety of rivaroxaban in patients with diabetes and nonvalvular atrial_fibrillation : The Rivaroxaban Once-daily , Oral , Direct Factor_Xa Inhibition Compared with Vitamin_K Antagonism for Prevention of Stroke and Embolism Trial in Atrial_Fibrillation -LRB- ROCKET AF Trial -RRB- .
22041909	0	Vitamin_K1	0,10	intestinal_alkaline_phosphatase	65,96	Vitamin K1	intestinal alkaline phosphatase	MESH:D010837	11648(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Vitamin_K1 -LRB- phylloquinone -RRB- or vitamin_K2 -LRB- menaquinone-4 -RRB- induces intestinal_alkaline_phosphatase gene expression .
23229512	0	Vitamin_K2	0,10	Bak	31,34	Vitamin K2	Bak	MESH:D024482	12018(Tax:10090)	Chemical	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Vitamin_K2 covalently binds to Bak and induces Bak-mediated apoptosis .
19624770	0	Vitamin_K2	0,10	fibroblast_growth_factor_receptor_3	43,78	Vitamin K2	fibroblast growth factor receptor 3	MESH:D024482	2261	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|nmod|END_ENTITY	Vitamin_K2 downregulates the expression of fibroblast_growth_factor_receptor_3 in human hepatocellular_carcinoma cells .
10737225	0	Vitamin_K2	0,10	iNOS	35,39	Vitamin K2	iNOS	MESH:D024482	282876(Tax:9913)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Vitamin_K2 -LRB- menatetrenone -RRB- induces iNOS in bovine vascular smooth muscle cells : no relationship between nitric_oxide production and gamma-carboxylation .
16141794	0	Vitamin_K_epoxide	15,32	VKORC1	54,60	Vitamin K epoxide	VKORC1	MESH:C016186	79001	Chemical	Gene	reductase|compound|START_ENTITY reductase|appos|END_ENTITY	Association of Vitamin_K_epoxide reductase complex 1 -LRB- VKORC1 -RRB- variants with warfarin dose in a Hong Kong Chinese patient population .
17202857	0	Vitexin	0,7	HIF-1alpha	12,22	Vitexin	HIF-1alpha	MESH:C032731	29560(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Vitexin , an HIF-1alpha inhibitor , has anti-metastatic potential in PC12 cells .
26187393	0	Vitexin	0,7	HIF-1alpha	76,86	Vitexin	HIF-1alpha	MESH:C032731	29560(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|nmod|inhibition inhibition|nmod|END_ENTITY	Vitexin reduces hypoxia-ischemia neonatal brain_injury by the inhibition of HIF-1alpha in a rat pup model .
23742617	0	Vitexin	0,7	TRPV1	56,61	Vitexin	TRPV1	MESH:C032731	193034(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	Vitexin inhibits inflammatory_pain in mice by targeting TRPV1 , oxidative stress , and cytokines .
22164771	0	Vitexin	0,7	ubiquitin-conjugating_enzyme_E2-25K	48,83	Vitexin	ubiquitin-conjugating enzyme E2-25K	MESH:C032731	3093	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Vitexin inhibits polyubiquitin synthesis by the ubiquitin-conjugating_enzyme_E2-25K .
25248999	0	Volitinib	0,9	c-Met	41,46	Volitinib	c-Met	null	4233	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Volitinib , a potent and highly selective c-Met inhibitor , effectively blocks c-Met signaling and growth in c-MET amplified gastric_cancer patient-derived tumor xenograft models .
11893416	0	Vomitoxin	0,9	IL-2	87,91	Vomitoxin	IL-2	MESH:C007262	16183(Tax:10090)	Chemical	Gene	START_ENTITY|dep|inhibition inhibition|amod|binding binding|nmod|NRE-A NRE-A|appos|promoter promoter|compound|END_ENTITY	Vomitoxin -LRB- deoxynivalenol -RRB- - mediated inhibition of nuclear protein binding to NRE-A , an IL-2 promoter negative regulatory element , in EL-4 cells .
21383338	0	Voriconazole	58,70	CYP2C19	10,17	Voriconazole	CYP2C19	MESH:C102790	1557	Chemical	Gene	Pharmacokinetics|nmod|START_ENTITY Polymorphism|nmod|Pharmacokinetics Polymorphism|compound|END_ENTITY	Effect of CYP2C19 Polymorphism on the Pharmacokinetics of Voriconazole After Single and Multiple Doses in Healthy Volunteers .
20631069	0	Vorinostat	0,10	CD95	34,38	Vorinostat	CD95	MESH:C111237	355	Chemical	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Vorinostat and sorafenib increase CD95 activation in gastrointestinal_tumor cells through a Ca -LRB- 2 + -RRB- - de novo ceramide-PP2A-reactive oxygen species-dependent signaling pathway .
23147569	0	Vorinostat	0,10	HDAC	15,19	Vorinostat	HDAC	MESH:C111237	9734	Chemical	Gene	attenuates|advmod|START_ENTITY attenuates|nsubj|inhibitor inhibitor|compound|END_ENTITY	Vorinostat , an HDAC inhibitor attenuates epidermoid_squamous_cell_carcinoma growth by dampening mTOR signaling pathway in a human xenograft murine model .
26330748	0	Vorinostat	46,56	HDAC	58,62	Vorinostat	HDAC	MESH:C111237	9734	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Role of 5 ` TG3 ' - interacting factors -LRB- TGIFs -RRB- in Vorinostat -LRB- HDAC inhibitor -RRB- - mediated Corneal_Fibrosis Inhibition .
17417771	0	Vorinostat	64,74	Histone_deacetylase	0,19	Vorinostat	Histone deacetylase	MESH:C111237	9734	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Histone_deacetylase inhibitor , suberoylanilide_hydroxamic_acid -LRB- Vorinostat , SAHA -RRB- profoundly inhibits the growth of human pancreatic_cancer cells .
20378407	0	Vorinostat	0,10	histone_deacetylase	14,33	Vorinostat	histone deacetylase	MESH:C111237	9734	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Vorinostat , a histone_deacetylase inhibitor , combined with pelvic palliative radiotherapy for gastrointestinal_carcinoma : the Pelvic Radiation and Vorinostat -LRB- PRAVO -RRB- phase 1 study .
21421857	0	Vorinostat	0,10	norepinephrine_transporter	46,72	Vorinostat	norepinephrine transporter	MESH:C111237	6530	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Vorinostat increases expression of functional norepinephrine_transporter in neuroblastoma in vitro and in vivo model systems .
26389667	0	Vortioxetine	46,58	Serotonin_Transporter	72,93	Vortioxetine	Serotonin Transporter	null	6532	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of the Multimodal Antidepressant Drug Vortioxetine to the Human Serotonin_Transporter .
21798372	0	W146	51,55	sphingosine-1-phosphate_receptor-1	4,38	W146	sphingosine-1-phosphate receptor-1	null	13609(Tax:10090)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	The sphingosine-1-phosphate_receptor-1 antagonist , W146 , causes early and short-lasting peripheral blood_lymphopenia in mice .
10499366	0	WAY-100635	54,64	5-HT1A	27,33	WAY-100635	5-HT1A	MESH:C090413	24473(Tax:10116)	Chemical	Gene	antagonist|dobj|START_ENTITY antagonist|nsubj|actions actions|nmod|receptor receptor|nummod|END_ENTITY	Synergistic actions of the 5-HT1A receptor antagonist WAY-100635 and citalopram on male rat ejaculatory behavior .
11356301	0	WAY-100635	0,10	5-HT1A	23,29	WAY-100635	5-HT1A	MESH:C090413	3350	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	WAY-100635 , a specific 5-HT1A antagonist , can increase the responsiveness of the mammalian circadian pacemaker to photic stimuli .
8566121	0	WAY-100635	78,88	5-HT1A	50,56	WAY-100635	5-HT1A	MESH:C090413	24473(Tax:10116)	Chemical	Gene	profile|amod|START_ENTITY profile|nmod|receptor receptor|amod|silent silent|dep|END_ENTITY	A pharmacological profile of the selective silent 5-HT1A receptor antagonist , WAY-100635 .
8788530	0	WAY-100635	78,88	5-HT1A	121,127	WAY-100635	5-HT1A	MESH:C090413	15550(Tax:10090)	Chemical	Gene	studies|nmod|START_ENTITY Electrophysiological|appos|studies Electrophysiological|appos|antagonist antagonist|amod|END_ENTITY	Electrophysiological , biochemical , neurohormonal and behavioural studies with WAY-100635 , a potent , selective and silent 5-HT1A receptor antagonist .
16915381	0	WAY-100635	0,10	dopamine_D4_receptor	23,43	WAY-100635	dopamine D4 receptor	MESH:C090413	1815	Chemical	Gene	agonist|nsubj|START_ENTITY agonist|amod|END_ENTITY	WAY-100635 is a potent dopamine_D4_receptor agonist .
8548382	0	WAY-126299A	26,37	5-lipoxygenase	53,67	WAY-126299A	5-lipoxygenase	MESH:C097665	240	Chemical	Gene	pharmacology|nmod|START_ENTITY pharmacology|dep|inhibitor inhibitor|amod|END_ENTITY	Pulmonary pharmacology of WAY-126299A : a dual-acting 5-lipoxygenase inhibitor and leukotriene D4 antagonist .
14623266	0	WAY-140312	0,10	PAI-1	26,31	WAY-140312	PAI-1	MESH:C496986	5054	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	WAY-140312 reduces plasma PAI-1 while maintaining normal platelet_aggregation .
18423777	0	WAY-200070	0,10	estrogen_receptor_beta	35,57	WAY-200070	estrogen receptor beta	MESH:C502077	13983(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonist agonist|nmod|END_ENTITY	WAY-200070 , a selective agonist of estrogen_receptor_beta as a potential novel anxiolytic/antidepressant agent .
16755255	0	WAY-202196	0,10	estrogen_receptor-beta	24,46	WAY-202196	estrogen receptor-beta	MESH:C501752	13983(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	WAY-202196 , a selective estrogen_receptor-beta agonist , protects against death in experimental septic_shock .
8365456	0	WAY100135	0,9	5-HT1A	73,79	WAY100135	5-HT1A	MESH:C081293	24473(Tax:10116)	Chemical	Gene	START_ENTITY|dep|antagonist antagonist|nmod|receptors receptors|amod|END_ENTITY	WAY100135 : a novel , selective antagonist at presynaptic and postsynaptic 5-HT1A receptors .
9219875	5	WAY100135	683,692	5-HT1A	705,711	WAY100135	5-HT1A	MESH:C081293	24473(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	This effect was reversed by pretreatment with -LRB- + -RRB- - WAY100135 , a specific 5-HT1A antagonist .
7770608	0	WAY100289	41,50	5-HT3_receptor	14,28	WAY100289	5-HT3 receptor	MESH:C077614	79246(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	The selective 5-HT3_receptor antagonist , WAY100289 , enhances spatial memory in rats with ibotenate lesions of the forebrain cholinergic projection system .
11104831	0	WAY_100635	38,48	5-HT1A	52,58	WAY 100635	5-HT1A	MESH:C090413	24473(Tax:10116)	Chemical	Gene	values|nmod|START_ENTITY values|nmod|receptors receptors|nummod|END_ENTITY	Estimation of apparent pA2 values for WAY_100635 at 5-HT1A receptors regulating 5-hydroxytryptamine release in anaesthetised rats .
12589378	0	WAY_100635	29,39	5-HT1A	10,16	WAY 100635	5-HT1A	MESH:C090413	24473(Tax:10116)	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|amod|Selective Selective|dep|END_ENTITY	Selective 5-HT1A antagonists WAY_100635 and NAD-299 attenuate the impairment of passive avoidance caused by scopolamine in the rat .
8912403	0	WAY_100635	23,33	5-HT1A	4,10	WAY 100635	5-HT1A	MESH:C090413	3350	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	The 5-HT1A antagonist , WAY_100635 , ameliorates the cognitive_impairment induced by fornix transection in the marmoset .
9272757	0	WAY_100635	208,218	5-HT1A	189,195	WAY 100635	5-HT1A	MESH:C090413	3350	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	On the elevated plus-maze the anxiolytic-like effects of the 5-HT -LRB- 1A -RRB- agonist , 8-OH-DPAT , but not the anxiogenic-like effects of the 5-HT -LRB- 1A -RRB- partial agonist , buspirone , are blocked by the 5-HT1A antagonist , WAY_100635 .
9650846	0	WAY_100635	11,21	5-HT1A	54,60	WAY 100635	5-HT1A	MESH:C090413	24473(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|dep|Me-8-OH-DPAT Me-8-OH-DPAT|appos|antagonist antagonist|nummod|END_ENTITY	Effects of WAY_100635 and -LRB- - -RRB- -5 - Me-8-OH-DPAT , a novel 5-HT1A receptor antagonist , on 8-OH-DPAT responses .
9826108	0	WAY_100635	44,54	5-HT1A	25,31	WAY 100635	5-HT1A	MESH:C090413	15550(Tax:10090)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	The silent and selective 5-HT1A antagonist , WAY_100635 , produces via an indirect mechanism , a 5-HT2A_receptor-mediated behaviour in mice during the day but not at night .
10462129	0	WAY_100635	0,10	5-HT1A_receptor	14,29	WAY 100635	5-HT1A receptor	MESH:C090413	3350	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	WAY_100635 , a 5-HT1A_receptor antagonist , prevents the impairment_of_spatial_learning caused by blockade of hippocampal NMDA receptors .
9328615	0	WAY_100635	32,42	5-HT1A_receptor	50,65	WAY 100635	5-HT1A receptor	MESH:C090413	3350	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Electrophysiological effects of WAY_100635 , a new 5-HT1A_receptor antagonist , on dorsal raphe nucleus serotoninergic neurones and CA1 pyramidal cells in vitro .
9452205	0	WAY_100635	0,10	5-HT1A_receptor	14,29	WAY 100635	5-HT1A receptor	MESH:C090413	3350	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	WAY_100635 , a 5-HT1A_receptor antagonist , prevents the impairment_of_spatial_learning caused by intrahippocampal administration of scopolamine or 7-chloro-kynurenic_acid .
9884117	0	WAY_100635	122,132	5-HT1A_receptor	94,109	WAY 100635	5-HT1A receptor	MESH:C090413	15550(Tax:10090)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Tolerance to acute anxiolysis but no withdrawal anxiogenesis in mice treated chronically with 5-HT1A_receptor antagonist , WAY_100635 .
1819688	0	WEB_2086	33,41	PAF	45,48	WEB 2086	PAF	MESH:C052518	9768	Chemical	Gene	START_ENTITY|nmod|induced induced|compound|END_ENTITY	Inhibition by the PAF antagonist WEB_2086 of PAF induced inositol-1 ,4,5 - trisphosphate production in human platelets .
2718150	0	WEB_2086	78,86	PAF	61,64	WEB 2086	PAF	MESH:C052518	300795(Tax:10116)	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|platelet_activating_factor platelet_activating_factor|appos|END_ENTITY	Protective effects of a specific platelet_activating_factor -LRB- PAF -RRB- antagonist , WEB_2086 , in traumatic_shock .
9686442	0	WEB_2086	22,30	PAF	32,35	WEB 2086	PAF	MESH:C052518	540737(Tax:9913)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Protective effects of WEB_2086 -LRB- PAF antagonist -RRB- and ketoprofen -LRB- NSAID -RRB- on PAF-induced changes in the morphological ultrastructure of blood platelets in calves .
3664079	0	WEB_2086	89,97	Paf	116,119	WEB 2086	Paf	MESH:C052518	300795(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Bronchial and vascular effects of Paf in the rat isolated lung are completely blocked by WEB_2086 , a novel specific Paf antagonist .
3664079	0	WEB_2086	89,97	Paf	34,37	WEB 2086	Paf	MESH:C052518	300795(Tax:10116)	Chemical	Gene	blocked|nmod|START_ENTITY isolated|ccomp|blocked isolated|nsubj|effects effects|nmod|END_ENTITY	Bronchial and vascular effects of Paf in the rat isolated lung are completely blocked by WEB_2086 , a novel specific Paf antagonist .
2311732	0	WEB_2086	63,71	platelet_activating_factor	14,40	WEB 2086	platelet activating factor	MESH:C052518	9768	Chemical	Gene	action|nmod|START_ENTITY action|nmod|END_ENTITY	The action of platelet_activating_factor and its antagonism by WEB_2086 on human isolated airways .
2718150	0	WEB_2086	78,86	platelet_activating_factor	33,59	WEB 2086	platelet activating factor	MESH:C052518	300795(Tax:10116)	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|END_ENTITY	Protective effects of a specific platelet_activating_factor -LRB- PAF -RRB- antagonist , WEB_2086 , in traumatic_shock .
3598913	0	WEB_2086	27,35	platelet_activating_factor	66,92	WEB 2086	platelet activating factor	MESH:C052518	300795(Tax:10116)	Chemical	Gene	actions|nmod|START_ENTITY actions|appos|antagonist antagonist|nmod|END_ENTITY	Pharmacological actions of WEB_2086 , a new specific antagonist of platelet_activating_factor .
1618265	0	WEB_2170	56,64	PAF_receptor	31,43	WEB 2170	PAF receptor	MESH:C063964	19204(Tax:10090)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	Differential inhibition by the PAF_receptor antagonist , WEB_2170 , of allergic_inflammation in single sensitized and boosted mice .
1819736	0	WEB_2170	76,84	platelet-activating_factor	28,54	WEB 2170	platelet-activating factor	MESH:C063964	109585(Tax:10090)	Chemical	Gene	antagonist|dobj|START_ENTITY antagonist|nsubj|Effect Effect|nmod|END_ENTITY	Effect of the hetrazepinoic platelet-activating_factor antagonist Bepafant -LRB- WEB_2170 -RRB- in models of active and passive anaphylaxis in mice and guinea_pigs .
16365309	0	WIN55,212-2	24,35	CB1	72,75	WIN55,212-2	CB1	MESH:C070417	1268	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|calcium calcium|nmod|coupling coupling|compound|END_ENTITY	The cannabinoid agonist WIN55,212-2 increases intracellular calcium via CB1 receptor coupling to Gq/11 G proteins .
16609959	0	WIN55,212-2	20,31	CB1	100,103	WIN55,212-2	CB1	MESH:C070417	1268	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|apoptosis apoptosis|nmod|cells cells|nmod|activation activation|nmod|receptor receptor|compound|END_ENTITY	Cannabinoid agonist WIN55,212-2 induces apoptosis in cerebellar granule cells via activation of the CB1 receptor and downregulation of bcl-xL gene expression .
17644088	0	WIN55,212-2	122,133	CB1	20,23	WIN55,212-2	CB1	MESH:C070417	12801(Tax:10090)	Chemical	Gene	activity|nmod|START_ENTITY THC|dep|activity +|appos|THC modulation|nmod|+ Role|nmod|modulation Role|nmod|receptors receptors|compound|END_ENTITY	Role of cannabinoid CB1 receptors and Gi/o protein activation in the modulation of synaptosomal Na + , K + - ATPase activity by WIN55,212-2 and delta -LRB- 9 -RRB- - THC .
19540252	0	WIN55,212-2	22,33	CB1	63,66	WIN55,212-2	CB1	MESH:C070417	1268	Chemical	Gene	exposure|nmod|START_ENTITY causes|nsubj|exposure causes|dobj|downregulation downregulation|nmod|receptor receptor|compound|END_ENTITY	Prolonged exposure to WIN55,212-2 causes downregulation of the CB1 receptor and the development of tolerance to its anticonvulsant effects in the hippocampal neuronal culture model of acquired_epilepsy .
22516010	0	WIN55,212-2	99,110	CB1	77,80	WIN55,212-2	CB1	MESH:C070417	25248(Tax:10116)	Chemical	Gene	effect|appos|START_ENTITY effect|nmod|administration administration|nmod|agonist agonist|compound|END_ENTITY	The amnesic effect of intra-central amygdala administration of a cannabinoid CB1 receptor agonist , WIN55,212-2 , is mediated by a b-1 noradrenergic system in rat .
24867078	0	WIN55,212-2	0,11	CB1	79,82	WIN55,212-2	CB1	MESH:C070417	25248(Tax:10116)	Chemical	Gene	impairs|nsubj|START_ENTITY impairs|dobj|recognition recognition|nmod|rats rats|nmod|stimulation stimulation|compound|END_ENTITY	WIN55,212-2 impairs non-associative recognition and spatial memory in rats via CB1 receptor stimulation .
26803309	0	WIN55,212-2	25,36	CB1	0,3	WIN55,212-2	CB1	MESH:C070417	1268	Chemical	Gene	Agonist|appos|START_ENTITY Agonist|compound|END_ENTITY	CB1 Cannabinoid Agonist -LRB- WIN55,212-2 -RRB- Within the Basolateral Amygdala Induced Sensitization to Morphine and Increased the Level of - Opioid Receptor and c-fos in the Nucleus Accumbens .
19214751	0	WIN55,212-2	0,11	CX3CL1	35,41	WIN55,212-2	CX3CL1	MESH:C070417	6376	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|nmod|END_ENTITY	WIN55,212-2 inhibits production of CX3CL1 by human astrocytes : involvement of p38 MAP kinase .
20164830	0	WIN55,212-2	51,62	GASP1	66,71	WIN55,212-2	GASP1	MESH:C070417	67298(Tax:10090)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of behavioral tolerance to WIN55,212-2 by GASP1 .
7582533	0	WIN_64338	11,20	bradykinin_B2_receptor	35,57	WIN 64338	bradykinin B2 receptor	MESH:C087374	100135486(Tax:10141)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|antagonist antagonist|amod|END_ENTITY	Effects of WIN_64338 , a nonpeptide bradykinin_B2_receptor antagonist , on guinea-pig trachea .
20522531	0	WJD008	0,6	mammalian_target_of_rapamycin	52,81	WJD008	mammalian target of rapamycin	MESH:C552255	2475	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	WJD008 , a dual phosphatidylinositol 3-kinase -LRB- PI3K -RRB- / mammalian_target_of_rapamycin inhibitor , prevents PI3K signaling and inhibits the proliferation of transformed cells with oncogenic PI3K mutant .
19456279	0	WO-2008057254	29,42	MMP-12	10,16	WO-2008057254	MMP-12	null	4321	Chemical	Gene	inhibitors|dep|START_ENTITY inhibitors|compound|END_ENTITY	Selective MMP-12 inhibitors : WO-2008057254 .
22356552	0	WO2011134971	14,26	Syk	52,55	WO2011134971	Syk	null	6850	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Evaluation of WO2011134971 , chiral 1,6-napthyridine Syk kinase inhibitors .
18245540	0	WP1066	0,6	JAK2	16,20	WP1066	JAK2	MESH:C519885	3717	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	WP1066 , a novel JAK2 inhibitor , suppresses proliferation and induces apoptosis in erythroid human cells carrying the JAK2 V617F mutation .
20461084	0	WP1066	16,22	STAT3	0,5	WP1066	STAT3	MESH:C519885	6774	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|END_ENTITY	STAT3 inhibitor WP1066 as a novel therapeutic agent for renal_cell_carcinoma .
25084036	0	WP1066	16,22	STAT3	0,5	WP1066	STAT3	MESH:C519885	25125(Tax:10116)	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|END_ENTITY	STAT3 inhibitor WP1066 as a novel therapeutic agent for bCCI neuropathic_pain rats .
26563331	0	WP1066	26,32	STAT3	37,42	WP1066	STAT3	MESH:C519885	20848(Tax:10090)	Chemical	Gene	Administration|nmod|START_ENTITY Administration|appos|Inhibitor Inhibitor|compound|END_ENTITY	Delayed Administration of WP1066 , an STAT3 Inhibitor , Ameliorates Radiation-Induced Lung_Injury in Mice .
17202319	0	WP1130	53,59	Bcr/Abl	22,29	WP1130	Bcr/Abl	MESH:C519751	25	Chemical	Gene	pathway|nmod|START_ENTITY pathway|compound|END_ENTITY	Activation of a novel Bcr/Abl destruction pathway by WP1130 induces apoptosis of chronic_myelogenous_leukemia cells .
11960601	0	WP631	76,81	c-myc	45,50	WP631	c-myc	MESH:C104426	4609	Chemical	Gene	transcription|nmod|START_ENTITY transcription|amod|END_ENTITY	Induction of G -LRB- 2 -RRB- / M arrest and inhibition of c-myc and p53 transcription by WP631 in Jurkat T lymphocytes .
1371988	0	WR-2721	88,95	granulocyte_colony-stimulating_factor	31,68	WR-2721	granulocyte colony-stimulating factor	MESH:D004999	12985(Tax:10090)	Chemical	Gene	administration|compound|START_ENTITY administration|compound|END_ENTITY	Postirradiation treatment with granulocyte_colony-stimulating_factor and preirradiation WR-2721 administration synergize to enhance hemopoietic reconstitution and increase survival .
12531896	0	WR1065	30,36	p53	47,50	WR1065	p53	MESH:C020174	7157	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	The cytoprotective aminothiol WR1065 activates p53 through a non-genotoxic signaling pathway involving c-Jun_N-terminal_kinase .
15750621	0	WR1065	11,17	p53	84,87	WR1065	p53	MESH:C020174	7157	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|presence presence|nmod|END_ENTITY	Aminothiol WR1065 induces differential gene expression in the presence of wild-type p53 .
8388310	0	WR_2721	39,46	acetylcholinesterase	63,83	WR 2721	acetylcholinesterase	MESH:D004999	83817(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Influence of the radioprotective agent WR_2721 on the striatal acetylcholinesterase activity in the rat .
10319915	0	WY-50295_tromethamine	0,21	5-lipoxygenase	25,39	WY-50295 tromethamine	5-lipoxygenase	null	240	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	WY-50295_tromethamine : a 5-lipoxygenase inhibitor without activity in human whole blood .
26792718	0	WYE-687	26,33	mTOR	37,41	WYE-687	mTOR	null	21977(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Preclinical evaluation of WYE-687 , a mTOR kinase inhibitor , as a potential anti-acute_myeloid_leukemia agent .
15377889	0	WY_14643	0,8	PPAR-alpha	29,39	WY 14643	PPAR-alpha	MESH:C006253	25747(Tax:10116)	Chemical	Gene	START_ENTITY|appos|ligand ligand|amod|END_ENTITY	WY_14643 , a potent exogenous PPAR-alpha ligand , reduces intestinal injury associated with splanchnic_artery_occlusion shock .
22157722	0	WZ4002	0,6	EGFR	27,31	WZ4002	EGFR	MESH:C571455	1956	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	WZ4002 , a third-generation EGFR inhibitor , can overcome anoikis resistance in EGFR-mutant lung_adenocarcinomas more efficiently than Src inhibitors .
26423308	0	Warfarin	9,17	Prothrombin	23,34	Warfarin	Prothrombin	MESH:D014859	2147	Chemical	Gene	START_ENTITY|nmod|Ratio Ratio|compound|END_ENTITY	Low-Dose Warfarin With Prothrombin Time-International Normalized Ratio Between 1.6 and 2.6 for Very Old Japanese Patients .
23076676	0	Wedelolactone	0,13	Akt	160,163	Wedelolactone	Akt	MESH:C051122	207	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|inhibiting inhibiting|dobj|END_ENTITY	Wedelolactone , a medicinal plant-derived coumestan , induces caspase-dependent apoptosis in prostate_cancer cells via downregulation of PKC without inhibiting Akt .
20053782	0	Withaferin-A	22,34	Notch-1	0,7	Withaferin-A	Notch-1	MESH:C009684	4851	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Notch-1 inhibition by Withaferin-A : a therapeutic target against colon_carcinogenesis .
19439083	0	Withaferin_A	46,58	NFkappaB	14,22	Withaferin A	NFkappaB	MESH:C009684	4790	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of NFkappaB by the natural product Withaferin_A in cellular models of Cystic_Fibrosis_inflammation .
22965833	0	Withaferin_A	0,12	Notch2	34,40	Withaferin A	Notch2	MESH:C009684	4853	Chemical	Gene	causes|nsubj|START_ENTITY causes|dobj|activation activation|nmod|END_ENTITY	Withaferin_A causes activation of Notch2 and Notch4 in human breast_cancer cells .
26186445	0	Withaferin_A	64,76	Vimentin	0,8	Withaferin A	Vimentin	MESH:C009684	22352(Tax:10090)	Chemical	Gene	Sensitivity|nmod|START_ENTITY Sensitivity|compound|END_ENTITY	Vimentin Phosphorylation Underlies Myofibroblast Sensitivity to Withaferin_A In Vitro and during Corneal Fibrosis .
23091278	0	Withaferin_A	0,12	annexin_A2	58,68	Withaferin A	annexin A2	MESH:C009684	302	Chemical	Gene	binds|nsubj|START_ENTITY binds|nmod|domain domain|nmod|END_ENTITY	Withaferin_A binds covalently to the N-terminal domain of annexin_A2 .
19345731	0	Withaferin_A	0,12	death_receptor_5	106,122	Withaferin A	death receptor 5	MESH:C009684	8795	Chemical	Gene	sensitizes|nsubj|START_ENTITY sensitizes|nmod|up-regulation up-regulation|nmod|END_ENTITY	Withaferin_A sensitizes TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of death_receptor_5 and down-regulation of c-FLIP .
24632454	0	Withaferin_A	0,12	endothelial_protein_C_receptor	32,62	Withaferin A	endothelial protein C receptor	MESH:C009684	10544	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Withaferin_A is an inhibitor of endothelial_protein_C_receptor shedding in vitro and in vivo .
20724373	0	Withaferin_A	0,12	signal_transducer_and_activator_of_transcription_3	36,86	Withaferin A	signal transducer and activator of transcription 3	MESH:C009684	6774	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	Withaferin_A inhibits activation of signal_transducer_and_activator_of_transcription_3 in human breast_cancer cells .
23667686	0	Withaferin_A	0,12	vimentin	41,49	Withaferin A	vimentin	MESH:C009684	100008924(Tax:9986)	Chemical	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Withaferin_A effectively targets soluble vimentin in the glaucoma filtration surgical model of fibrosis .
25969759	0	Withaferin_a	0,12	breast_cancer_susceptibility_gene_1	57,92	Withaferin a	breast cancer susceptibility gene 1	MESH:C009684	672	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|degradation degradation|nmod|END_ENTITY	Withaferin_a induces proteasome-dependent degradation of breast_cancer_susceptibility_gene_1 and heat_shock factor 1 proteins in breast_cancer cells .
21432907	0	Withaferin_a	0,12	estrogen_receptor-a	24,43	Withaferin a	estrogen receptor-a	MESH:C009684	2099	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Withaferin_a suppresses estrogen_receptor-a expression in human breast_cancer cells .
19950196	0	Withangulatin_A	30,45	COX-2	69,74	Withangulatin A	COX-2	MESH:C059043	17709(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Anti-inflammatory function of Withangulatin_A by targeted inhibiting COX-2 expression via MAPK and NF-kappaB pathways .
22846543	0	Wogonin	0,7	AMPK	44,48	Wogonin	AMPK	MESH:C085514	5563	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|activating activating|dobj|END_ENTITY	Wogonin induces apoptosis by activating the AMPK and p53 signaling pathways in human glioblastoma cells .
19935879	0	Wogonin	0,7	Cdk4	51,55	Wogonin	Cdk4	MESH:C085514	1019	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Wogonin induces G1 phase arrest through inhibiting Cdk4 and cyclin_D1 concomitant with an elevation in p21Cip1 in human cervical_carcinoma HeLa cells .
17052690	0	Wogonin	0,7	MMP-9	37,42	Wogonin	MMP-9	MESH:C085514	4318	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Wogonin suppresses TNF-alpha-induced MMP-9 expression by blocking the NF-kappaB activation via MAPK signaling pathways in human_aortic_smooth_muscle_cells .
15816529	0	Wogonin	0,7	N-acetyltransferase	17,36	Wogonin	N-acetyltransferase	MESH:C085514	6046	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Wogonin inhibits N-acetyltransferase activity and gene expression in human leukemia HL-60 cells .
17317108	0	Wogonin	0,7	TARC	19,23	Wogonin	TARC	MESH:C085514	6361	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Wogonin suppresses TARC expression induced by mite antigen via heme_oxygenase_1 in human keratinocytes .
16931628	0	Wogonin	0,7	TNFalpha	48,56	Wogonin	TNFalpha	MESH:C085514	7124	Chemical	Gene	sensitizes|nsubj|START_ENTITY sensitizes|nmod|END_ENTITY	Wogonin sensitizes resistant malignant cells to TNFalpha - and TRAIL-induced apoptosis .
18496814	0	Wogonin	0,7	cyclooxygenase-2	68,84	Wogonin	cyclooxygenase-2	MESH:C085514	5743	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Wogonin , a bioactive flavonoid in herbal tea , inhibits inflammatory cyclooxygenase-2 gene expression in human lung epithelial cancer cells .
26073326	0	Wogonin	0,7	osteopontin	19,30	Wogonin	osteopontin	MESH:C085514	20750(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Wogonin suppresses osteopontin expression in adipocytes by activating PPARa .
23071621	0	Wortmannin	0,10	Pcmt1	64,69	Wortmannin	Pcmt1	MESH:C009687	18537(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|nmod|END_ENTITY	Wortmannin reduces insulin signaling and death in seizure-prone Pcmt1 - / - mice .
8074671	0	Wortmannin	22,32	growth_hormone	68,82	Wortmannin	growth hormone	MESH:C009687	81668(Tax:10116)	Chemical	Gene	blocks|nsubj|START_ENTITY blocks|dobj|effects effects|nmod|END_ENTITY	PI-3-kinase inhibitor Wortmannin blocks the insulin-like effects of growth_hormone in isolated rat adipocytes .
1733924	0	Wortmannin	0,10	myosin_light_chain_kinase	45,70	Wortmannin	myosin light chain kinase	MESH:C009687	288057(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Wortmannin , a microbial product inhibitor of myosin_light_chain_kinase .
9398628	0	Wortmannin	0,10	phosphatidylinositol-3-kinase	36,65	Wortmannin	phosphatidylinositol-3-kinase	MESH:C009687	18708(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Wortmannin , a specific inhibitor of phosphatidylinositol-3-kinase , enhances LPS-induced NO production from murine peritoneal macrophages .
9144481	0	Wortmannin	0,10	phosphatidylinositol_3-kinase	14,43	Wortmannin	phosphatidylinositol 3-kinase	MESH:C009687	18708(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Wortmannin , a phosphatidylinositol_3-kinase inhibitor , blocks antigen-mediated , but not CD3 monoclonal antibody-induced , activation of murine CD4 + T cells .
8088323	0	Wortmannin	0,10	phospholipase_D	28,43	Wortmannin	phospholipase D	MESH:C009687	2822	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|activation activation|amod|END_ENTITY	Wortmannin , an inhibitor of phospholipase_D activation , selectively blocks major histocompatibility complex class II-restricted antigen presentation .
8521971	0	Wortmannin	0,10	polymeric_immunoglobulin_receptor	55,88	Wortmannin	polymeric immunoglobulin receptor	MESH:C009687	5284	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Wortmannin inhibits transcytosis of dimeric IgA by the polymeric_immunoglobulin_receptor .
10529360	0	Wy_14643	24,32	PPARalpha	0,9	Wy 14643	PPARalpha	MESH:C006253	25747(Tax:10116)	Chemical	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	PPARalpha activation by Wy_14643 induces transactivation of the rat UCP-1 promoter without increasing UCP-1 mRNA levels and attenuates PPARgamma-mediated increases in UCP-1 mRNA levels induced by rosiglitazone in fetal rat brown adipocytes .
12441171	0	XIB4035	0,7	GFRalpha-1	56,66	XIB4035	GFRalpha-1	MESH:C470912	14585(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonist agonist|nmod|END_ENTITY	XIB4035 , a novel nonpeptidyl small molecule agonist for GFRalpha-1 .
12516964	0	XK469	58,63	topoisomerase_IIbeta	79,99	XK469	topoisomerase IIbeta	MESH:C118180	7155	Chemical	Gene	inhibition|appos|START_ENTITY inhibition|nmod|END_ENTITY	2 - -LSB- 4 - -LRB- 7-chloro-2-quinoxalinyloxy -RRB- phenoxy -RSB- - propionic_acid -LRB- XK469 -RRB- inhibition of topoisomerase_IIbeta is not sufficient for therapeutic response in human Waldenstrom 's _ macroglobulinemia xenograft model .
24374145	0	XL019	22,27	JAK2	60,64	XL019	JAK2	null	3717	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Phase I evaluation of XL019 , an oral , potent , and selective JAK2 inhibitor .
22560567	0	XL413	13,18	CDC7	43,47	XL413	CDC7	null	8317	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Discovery of XL413 , a potent and selective CDC7 inhibitor .
22173702	0	XL647	83,88	EGFR	67,71	XL647	EGFR	MESH:C571826	1956	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	EGFR-mutant lung_adenocarcinomas treated first-line with the novel EGFR inhibitor , XL647 , can subsequently retain moderate sensitivity to erlotinib .
22351686	0	XL888	20,25	BRAF	36,40	XL888	BRAF	MESH:C559121	673	Chemical	Gene	overcomes|nsubj|START_ENTITY overcomes|dobj|resistance resistance|amod|END_ENTITY	The HSP90 inhibitor XL888 overcomes BRAF inhibitor resistance mediated through diverse mechanisms .
22877636	0	XL888	13,18	HSP90	72,77	XL888	HSP90	MESH:C559121	111058(Tax:10090)	Chemical	Gene	Discovery|nmod|START_ENTITY Discovery|dep|inhibitor inhibitor|nmod|END_ENTITY	Discovery of XL888 : a novel tropane-derived small molecule inhibitor of HSP90 .
8583775	0	XR510	16,21	AT1	72,75	XR510	AT1	MESH:C095055	24180(Tax:10116)	Chemical	Gene	antagonist|nmod|START_ENTITY antagonist|nsubj|receptor receptor|compound|END_ENTITY	Pharmacology of XR510 , a potent orally active nonpeptide angiotensin II AT1 receptor antagonist with high affinity for the AT2 receptor subtype .
12243872	7	XT-141	1234,1240	P-gp	1291,1295	XT-141	P-gp	null	67078(Tax:10090)	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|nmod|END_ENTITY	These results indicated that the resistance of P388/DOX might depend on the over-expression of P-gp , and that XT-141 inhibited DOX efflux through its interaction with P-gp .
2870611	0	Xamoterol	0,9	beta-1-adrenoceptor	27,46	Xamoterol	beta-1-adrenoceptor	MESH:D017307	153	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Xamoterol , a new selective beta-1-adrenoceptor partial agonist , in the treatment of postural_hypotension .
26617743	0	Xanthatin	0,9	VEGFR2	39,45	Xanthatin	VEGFR2	MESH:C022186	3791	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|signaling signaling|compound|END_ENTITY	Xanthatin , a novel potent inhibitor of VEGFR2 signaling , inhibits angiogenesis and tumor growth in breast_cancer cells .
22038782	0	Xanthoangelols	0,14	plasminogen_activator_inhibitor_1	75,108	Xanthoangelols	plasminogen activator inhibitor 1	null	5054	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|production production|amod|END_ENTITY	Xanthoangelols isolated from Angelica keiskei inhibit inflammatory-induced plasminogen_activator_inhibitor_1 -LRB- PAI-1 -RRB- production .
21616523	0	Xanthohumol	0,11	Notch1	22,28	Xanthohumol	Notch1	MESH:C104536	4851	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|amod|END_ENTITY	Xanthohumol decreases Notch1 expression and cell growth by cell cycle arrest and induction of apoptosis in epithelial_ovarian_cancer cell lines .
20226902	0	Xanthohumol	0,11	achaete-scute_complex-like_1	61,89	Xanthohumol	achaete-scute complex-like 1	MESH:C104536	429	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Xanthohumol inhibits the neuroendocrine transcription factor achaete-scute_complex-like_1 , suppresses proliferation , and induces phosphorylated ERK1/2 in medullary_thyroid_cancer .
25005963	0	Xanthohumol	0,11	cholesteryl_ester_transfer_protein	69,103	Xanthohumol	cholesteryl ester transfer protein	MESH:C104536	1071	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Xanthohumol , a prenylated chalcone from Humulus lupulus L. , inhibits cholesteryl_ester_transfer_protein .
9366096	0	Xanthohumols	0,12	diacylglycerol_acyltransferase	14,44	Xanthohumols	diacylglycerol acyltransferase	null	84497(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitors inhibitors|amod|END_ENTITY	Xanthohumols , diacylglycerol_acyltransferase inhibitors , from Humulus lupulus .
25146964	0	Xanthone_Sulfonamides	67,88	ACAT	92,96	Xanthone Sulfonamides	ACAT	null	6646	Chemical	Gene	START_ENTITY|nmod|Inhibitors Inhibitors|compound|END_ENTITY	Synthesis , Biological Evaluation , and Molecular Docking Studies of Xanthone_Sulfonamides as ACAT Inhibitors .
20696581	0	Xanthones	0,9	neuraminidase	15,28	Xanthones	neuraminidase	MESH:D044004	4758	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Xanthones with neuraminidase inhibitory activity from the seedcases of Garcinia mangostana .
19860431	0	Xen2174	105,112	norepinephrine_transporter	67,93	Xen2174	norepinephrine transporter	MESH:C500187	83511(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	chi-Conopeptide pharmacophore development : toward a novel class of norepinephrine_transporter inhibitor -LRB- Xen2174 -RRB- for pain .
26939898	0	Xenon	15,20	Erythropoietin	31,45	Xenon	Erythropoietin	MESH:D014978	2056	Chemical	Gene	Levels|compound|START_ENTITY Levels|compound|END_ENTITY	Sub-anesthetic Xenon Increases Erythropoietin Levels in Humans : A Randomized Controlled Trial .
20087367	0	Xenon	0,5	tissue-plasminogen_activator	25,53	Xenon	tissue-plasminogen activator	MESH:D014978	25692(Tax:10116)	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Xenon is an inhibitor of tissue-plasminogen_activator : adverse and beneficial effects in a rat model of thromboembolic_stroke .
11959799	0	Xestospongin_C	0,14	IP3_receptor	35,47	Xestospongin C	IP3 receptor	MESH:C511704	25679(Tax:10116)	Chemical	Gene	START_ENTITY|appos|blocker blocker|nmod|END_ENTITY	Xestospongin_C , a novel blocker of IP3_receptor , attenuates the increase in cytosolic calcium level and degranulation that is induced by antigen in RBL-2H3 mast cells .
12215757	0	Ximelagatran	36,48	thrombin	17,25	Ximelagatran	thrombin	MESH:C426686	2147	Chemical	Gene	Prophylaxis|compound|START_ENTITY inhibitor|dobj|Prophylaxis inhibitor|nsubj|END_ENTITY	-LSB- The oral direct thrombin inhibitor Ximelagatran Prophylaxis of venous_thromboembolism in hip and knee replacement -RSB- .
12846597	0	Ximelagatran	0,12	thrombin	29,37	Ximelagatran	thrombin	MESH:C426686	2147	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Ximelagatran , an oral direct thrombin inhibitor , has a low potential for cytochrome_P450-mediated drug-drug interactions .
14606349	0	Ximelagatran	1,13	thrombin	23,31	Ximelagatran	thrombin	MESH:C426686	2147	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	-LSB- Ximelagatran , an oral thrombin inhibitor without the need for regular monitoring of the anticoagulant status -RSB- .
15102589	0	Ximelagatran	0,12	thrombin	36,44	Ximelagatran	thrombin	MESH:C426686	2147	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Ximelagatran : the first oral direct thrombin inhibitor .
15270973	0	Ximelagatran	0,12	thrombin	32,40	Ximelagatran	thrombin	MESH:C426686	2147	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Ximelagatran , a new oral direct thrombin inhibitor , for the prevention of venous thromboembolic_events in major elective orthopaedic surgery .
15619615	0	Ximelagatran	0,12	thrombin	86,94	Ximelagatran	thrombin	MESH:C426686	2147	Chemical	Gene	START_ENTITY|dep|pharmacokinetics pharmacokinetics|nmod|strategy strategy|nmod|inhibition inhibition|compound|END_ENTITY	Ximelagatran : pharmacokinetics and pharmacodynamics of a new strategy for oral direct thrombin inhibition .
15629364	0	Ximelagatran	0,12	thrombin	26,34	Ximelagatran	thrombin	MESH:C426686	2147	Chemical	Gene	START_ENTITY|dep|inhibition inhibition|compound|END_ENTITY	Ximelagatran : oral direct thrombin inhibition as anticoagulant therapy in atrial_fibrillation .
15998925	0	Ximelagatran	0,12	thrombin	38,46	Ximelagatran	thrombin	MESH:C426686	2147	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Ximelagatran : an orally active direct thrombin inhibitor .
16084146	0	Ximelagatran	100,112	thrombin	28,36	Ximelagatran	thrombin	MESH:C426686	2147	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|parataxis|inhibitor inhibitor|nsubj|review review|nmod|END_ENTITY	A review of the oral direct thrombin inhibitor ximelagatran : not yet the end of the warfarin era ... Ximelagatran is a direct thrombin inhibitor that offers numerous potential advantages compared with traditional anticoagulants .
17319469	0	Ximelagatran	0,12	thrombin	21,29	Ximelagatran	thrombin	MESH:C426686	2147	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Ximelagatran : direct thrombin inhibitor .
2565274	0	Xylamine	0,8	N-acetyltransferase	31,50	Xylamine	N-acetyltransferase	MESH:C026131	116631(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|compound|END_ENTITY	Xylamine enhances pineal gland N-acetyltransferase activity in vitro .
10880261	0	Y-24180	0,7	interleukin_5	65,78	Y-24180	interleukin 5	MESH:C068035	16191(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|production production|amod|END_ENTITY	Y-24180 , an antagonist of platelet-activating factor , suppresses interleukin_5 production in cultured murine th -LRB- 2 -RRB- cells and human peripheral blood mononuclear cells .
8957681	0	Y-24180	10,17	platelet-activating_factor-receptor	21,56	Y-24180	platelet-activating factor-receptor	MESH:C068035	100720710	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Effect of Y-24180 , a platelet-activating_factor-receptor antagonist , on the antigen-induced airway microvascular leakage in guinea_pigs .
10503965	0	Y-24180	66,73	platelet-activating_factor_receptor	92,127	Y-24180	platelet-activating factor receptor	MESH:C068035	5724	Chemical	Gene	eosinophils|nmod|START_ENTITY eosinophils|nmod|END_ENTITY	Inhibition of activation of human peripheral blood eosinophils by Y-24180 , an antagonist to platelet-activating_factor_receptor .
9669206	0	Y-24180	139,146	platelet-activating_factor_receptor	165,200	Y-24180	platelet-activating factor receptor	MESH:C068035	5724	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|nmod|END_ENTITY	Inhibition of leukotriene B4-induced increase in intracellular calcium ion level of human peripheral blood polymorphonuclear leukocytes by Y-24180 , an antagonist of platelet-activating_factor_receptor .
8330800	0	Y-25130	11,18	5-HT3_receptor	32,46	Y-25130	5-HT3 receptor	MESH:C070671	79246(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	-LSB- Effect of Y-25130 , a selective 5-HT3_receptor antagonist , on the intestinal fluid secretion in rats -RSB- .
16750189	0	Y-27632	22,29	Rho-kinase	0,10	Y-27632	Rho-kinase	MESH:C108830	19878(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Rho-kinase inhibitor , Y-27632 , has an antinociceptive effect in mice .
17010334	0	Y-27632	24,31	Rho-kinase	2,12	Y-27632	Rho-kinase	MESH:C108830	19878(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	A Rho-kinase inhibitor , Y-27632 , reduces cholinergic contraction but not neurotransmitter release .
11967018	4	Y-27632	595,602	SMalphaA	646,654	Y-27632	SMalphaA	MESH:C108830	11475(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	To investigate the therapeutic efficacy of Y-27632 in UUO kidneys , smooth_muscle_alpha_actin -LRB- SMalphaA -RRB- expression , macrophage infiltration and fibrosis in the obstructed kidneys were studied .
9336340	0	Y-29794	85,92	prolyl_endopeptidase	53,73	Y-29794	prolyl endopeptidase	MESH:C077994	19072(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Prevention of amyloid-like_deposition by a selective prolyl_endopeptidase inhibitor , Y-29794 , in senescence-accelerated mouse .
26775662	0	Y-QA31	0,6	dopamine_D3_receptor	16,36	Y-QA31	dopamine D3 receptor	null	13490(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Y-QA31 , a novel dopamine_D3_receptor antagonist , exhibits antipsychotic-like properties in preclinical animal models of schizophrenia .
24009780	0	Y2O3	62,66	CO2	37,40	Y2O3	CO2	null	717	Chemical	Gene	Study|nmod|START_ENTITY Study|nmod|END_ENTITY	In Situ FT-IR Spectroscopic Study of CO2 and CO_Adsorption on Y2O3 , ZrO2 , and Yttria-Stabilized ZrO2 .
23846322	0	YK-3-237	42,50	p53	17,20	YK-3-237	p53	null	7157	Chemical	Gene	Targeting|nmod|START_ENTITY Targeting|dobj|END_ENTITY	Targeting mutant p53 by a SIRT1 activator YK-3-237 inhibits the proliferation of triple-negative_breast_cancer cells .
11134650	0	YM-126414	10,19	glucose_transporter_isotype_4	60,89	YM-126414	glucose transporter isotype 4	MESH:C419845	20528(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of YM-126414 on glucose uptake and redistribution of glucose_transporter_isotype_4 in muscle cells .
2127525	0	YM-14673	11,19	TRH	27,30	YM-14673	TRH	MESH:C054995	25569(Tax:10116)	Chemical	Gene	START_ENTITY|appos|analogue analogue|compound|END_ENTITY	Effects of YM-14673 , a new TRH analogue , on behavioral and electrophysiological changes in rats subjected to electrical lesion of the internal capsule .
2505700	0	YM-14673	11,19	TRH	27,30	YM-14673	TRH	MESH:C054995	25569(Tax:10116)	Chemical	Gene	START_ENTITY|appos|analogue analogue|compound|END_ENTITY	Effects of YM-14673 , a new TRH analogue , on neurological_deficits in rats with experimental cerebral_hematoma .
1403605	0	YM-14673	0,8	thyrotropin-releasing_hormone	16,45	YM-14673	thyrotropin-releasing hormone	MESH:C054995	100717613	Chemical	Gene	START_ENTITY|appos|analog analog|amod|END_ENTITY	YM-14673 , a new thyrotropin-releasing_hormone analog , augments long-term potentiation in the mossy fiber-CA3 system of guinea_pig hippocampal slices .
7635174	0	YM-14673	0,8	thyrotropin-releasing_hormone	12,41	YM-14673	thyrotropin-releasing hormone	MESH:C054995	25569(Tax:10116)	Chemical	Gene	START_ENTITY|appos|analogue analogue|amod|END_ENTITY	YM-14673 , a thyrotropin-releasing_hormone analogue , injected into the nucleus accumbens and the striatum produces repetitive jaw_movements in rats .
2509218	0	YM-14673	10,18	thyrotropin_releasing_hormone	26,55	YM-14673	thyrotropin releasing hormone	MESH:C054995	22044(Tax:10090)	Chemical	Gene	START_ENTITY|appos|analogue analogue|compound|END_ENTITY	Effect of YM-14673 , a new thyrotropin_releasing_hormone analogue , on ataxic_gait in cytosine_arabinoside-treated mice .
20178047	0	YM-150	0,6	Factor_Xa	10,19	YM-150	Factor Xa	MESH:C569750	2159	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	YM-150 , a Factor_Xa inhibitor for the prevention of venous_thromboembolism and coronary_artery_disease .
23325792	6	YM-155	917,923	XIAP	977,981	YM-155	EGFR	MESH:C523798	1956	Chemical	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	No correlation was found between sensitivity to YM-155 and baseline expression of survivin or cIAP-1 / cIAP-2 / XIAP .
1815649	0	YM-21095	30,38	renin	69,74	YM-21095	renin	MESH:C074794	5972	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Pharmacological properties of YM-21095 , a potent and highly specific renin inhibitor .
8201530	0	YM-21095	47,55	renin	65,70	YM-21095	renin	MESH:C074794	403838(Tax:9615)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Pharmacokinetics and cardiovascular effects of YM-21095 , a novel renin inhibitor , in dogs and monkeys .
11716840	0	YM-31636	32,40	5-HT3_receptor	8,22	YM-31636	5-HT3 receptor	MESH:C419869	79246(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	A novel 5-HT3_receptor agonist , YM-31636 , increases_gastrointestinal_motility without increasing abdominal_pain .
16533791	0	YM-359445	0,9	vascular_endothelial_growth_factor_receptor-2	34,79	YM-359445	vascular endothelial growth factor receptor-2	MESH:C509950	3791	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	YM-359445 , an orally bioavailable vascular_endothelial_growth_factor_receptor-2 tyrosine kinase inhibitor , has highly potent antitumor activity against established_tumors .
8981420	0	YM-50001	0,8	dopamine_D4_receptor	40,60	YM-50001	dopamine D4 receptor	MESH:C104859	1815	Chemical	Gene	START_ENTITY|dep|antagonist antagonist|amod|END_ENTITY	YM-50001 : a novel , potent and selective dopamine_D4_receptor antagonist .
9531037	0	YM-60828	52,60	factor_Xa	119,128	YM-60828	factor Xa	MESH:C111032	2159	Chemical	Gene	characterization|nmod|START_ENTITY characterization|appos|inhibitor inhibitor|nmod|END_ENTITY	Biochemical and pharmacological characterization of YM-60828 , a newly synthesized and orally active inhibitor of human factor_Xa .
12469943	0	YM-90709	20,28	interleukin-5	81,94	YM-90709	interleukin-5	MESH:C475470	3567	Chemical	Gene	Characterization|nmod|START_ENTITY antagonist|nsubj|Characterization antagonist|ccomp|inhibits inhibits|dobj|the the|nmod|receptor receptor|amod|interleukin-5 interleukin-5|amod|END_ENTITY	Characterization of YM-90709 as a novel antagonist which inhibits the binding of interleukin-5 to interleukin-5 receptor .
12469943	0	YM-90709	20,28	interleukin-5	98,111	YM-90709	interleukin-5	MESH:C475470	3567	Chemical	Gene	Characterization|nmod|START_ENTITY antagonist|nsubj|Characterization antagonist|ccomp|inhibits inhibits|dobj|the the|nmod|receptor receptor|amod|END_ENTITY	Characterization of YM-90709 as a novel antagonist which inhibits the binding of interleukin-5 to interleukin-5 receptor .
15182727	0	YM-90709	53,61	interleukin-5	18,31	YM-90709	interleukin-5	MESH:C475470	24497(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Effect of a novel interleukin-5 receptor antagonist , YM-90709 -LRB- 2,3-dimethoxy-6 ,6 - dimethyl-5 ,6 - dihydrobenzo -LSB- 7,8 -RSB- indolizino -LSB- 2,3-b -RSB- quinoxaline -RRB- , on antigen-induced airway_inflammation in BN rats .
15790522	0	YM-90709	53,61	interleukin-5	18,31	YM-90709	interleukin-5	MESH:C475470	3567	Chemical	Gene	Effect|amod|START_ENTITY Effect|nmod|receptor receptor|amod|END_ENTITY	Effect of a novel interleukin-5 receptor antagonist , YM-90709 , on antigen-induced eosinophil infiltration into the airway of BDF1 mice .
8659718	0	YM022	94,99	cholecystokinin-B_receptor	103,129	YM022	cholecystokinin-B receptor	MESH:C087260	25706(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	The effects of intrathecally administered FK480 , a cholecystokinin-A_receptor antagonist , and YM022 , a cholecystokinin-B_receptor antagonist , on the formalin test in the rat .
7566499	0	YM114	78,83	5-HT3_receptor	43,57	YM114	5-HT3 receptor	MESH:C085986	79246(Tax:10116)	Chemical	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Comparative study of the affinities of the 5-HT3_receptor antagonists , YM060 , YM114 -LRB- KAE-393 -RRB- , granisetron and ondansetron in rat vagus nerve and cerebral cortex .
9208647	0	YM14673	51,58	thyrotropin-releasing_hormone	11,40	YM14673	thyrotropin-releasing hormone	MESH:C054995	25569(Tax:10116)	Chemical	Gene	analogue|appos|START_ENTITY analogue|amod|END_ENTITY	-LSB- Effect of thyrotropin-releasing_hormone analogue -LRB- YM14673 -RRB- on experimental brain contusion and edema in rats -RSB- .
20088935	0	YM150	71,76	factor_Xa	50,59	YM150	factor Xa	MESH:C569750	2159	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Prevention of venous_thromboembolism with an oral factor_Xa inhibitor , YM150 , after total hip arthroplasty .
21995444	0	YM150	109,114	factor_Xa	149,158	YM150	factor Xa	MESH:C569750	2159	Chemical	Gene	darexaban|dep|START_ENTITY benzamide|appos|darexaban benzamide|nmod|inhibitor inhibitor|compound|END_ENTITY	Discovery of N - -LSB- 2-hydroxy-6 - -LRB- 4-methoxybenzamido -RRB- phenyl -RSB- -4 - _ -LRB- 4-methyl-1 ,4 - diazepan-1-yl -RRB- benzamide -LRB- darexaban , YM150 -RRB- as a potent and orally available factor_Xa inhibitor .
23167531	0	YM150	51,56	factor_Xa	72,81	YM150	factor Xa	MESH:C569750	2159	Chemical	Gene	darexaban|appos|START_ENTITY Absorption|nmod|darexaban Absorption|appos|inhibitor inhibitor|compound|END_ENTITY	Absorption , metabolism and excretion of darexaban -LRB- YM150 -RRB- , a new direct factor_Xa inhibitor in humans .
23754514	0	YM150	11,16	factor_Xa	34,43	YM150	factor Xa	MESH:C569750	2159	Chemical	Gene	Darexaban|appos|START_ENTITY Darexaban|appos|inhibitor inhibitor|compound|END_ENTITY	Darexaban -LRB- YM150 -RRB- , an oral direct factor_Xa inhibitor , has no effect on the pharmacokinetics of digoxin .
22442257	0	YM155	59,64	NF110	38,43	YM155	NF110	MESH:C523798	3609	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Interleukin_enhancer-binding_factor_3 / NF110 is a target of YM155 , a suppressant of survivin .
25475012	0	YM155	0,5	specificity_protein_1	50,71	YM155	specificity protein 1	MESH:C523798	6667	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|downregulation downregulation|nmod|END_ENTITY	YM155 induces apoptosis through downregulation of specificity_protein_1 and myeloid_cell_leukemia-1 in human oral_cancer cell lines .
10071851	2	YM264	153,158	PAF	190,193	YM264	PAF	MESH:C068679	300795(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|factor factor|appos|END_ENTITY	Synthesis of metabolites and metabolism of 2 - -LRB- 3-pyridyl -RRB- thiazolidine-4-carboxamides YM461 and YM264 as platelet-activating factor -LRB- PAF -RRB- receptor antagonists .
2025290	0	YM264	11,16	PAF	26,29	YM264	PAF	MESH:C068679	300795(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Effects of YM264 , a novel PAF antagonist , on puromycin_aminonucleoside-induced nephropathy in the rat .
12132657	0	YM358	54,59	angiotensin_II_type_1_receptor	11,41	YM358	angiotensin II type 1 receptor	MESH:C105489	81638(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Effects of angiotensin_II_type_1_receptor antagonist , YM358 , on cardiac_hypertrophy_and_dysfunction after myocardial_infarction in rats .
17917254	0	YM466	68,73	factor_Xa	90,99	YM466	factor Xa	MESH:C111032	2159	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Experimental model of lower_limb_ischemia in rats and the effect of YM466 , an oral direct factor_Xa inhibitor .
23374077	0	YM543	36,41	SGLT2	78,83	YM543	SGLT2	null	246787(Tax:10090)	Chemical	Gene	Characterization|nmod|START_ENTITY Characterization|appos|Inhibitor Inhibitor|compound|END_ENTITY	Pharmacological Characterization of YM543 , a Newly Synthesized , Orally Active SGLT2 Selective Inhibitor .
10991987	0	YM976	44,49	phosphodiesterase_type_4	8,32	YM976	phosphodiesterase type 4	MESH:C414544	5141	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	A novel phosphodiesterase_type_4 inhibitor , YM976 -LRB- 4 - -LRB- 3-chlorophenyl -RRB- -1,7 - diethylpyrido -LSB- 2,3-d -RSB- pyrimidin-2 -LRB- 1H -RRB- - one -RRB- , with little emetogenic activity .
11504812	0	YM976	46,51	phosphodiesterase_type_4	61,85	YM976	phosphodiesterase type 4	MESH:C414544	5141	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Studies on mechanisms of low emetogenicity of YM976 , a novel phosphodiesterase_type_4 inhibitor .
537244	0	YP-279	111,117	dopamine_beta-hydroxylase	122,147	YP-279	dopamine beta-hydroxylase	MESH:C006080	1621	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Enhancement of dopamine-induced stimulation of pancreatic secretion by 5-dimethyldithiocarbamylpicolinic_acid -LRB- YP-279 -RRB- , a dopamine_beta-hydroxylase inhibitor .
21507153	0	YQA14	0,5	dopamine_D3_receptor	15,35	YQA14	dopamine D3 receptor	MESH:C571881	29238(Tax:10116)	Chemical	Gene	START_ENTITY|dep|antagonist antagonist|amod|END_ENTITY	YQA14 : a novel dopamine_D3_receptor antagonist that inhibits cocaine self-administration in rats and mice , but not in D3 receptor-knockout mice .
7753913	0	Yangambin	0,9	platelet-activating_factor_receptor	37,72	Yangambin	platelet-activating factor receptor	MESH:C082827	100354046(Tax:9986)	Chemical	Gene	START_ENTITY|dep|antagonist antagonist|compound|END_ENTITY	Yangambin : a new naturally-occurring platelet-activating_factor_receptor antagonist : binding and in vitro functional studies .
26417688	0	Yhhu4488	0,8	GPR40	18,23	Yhhu4488	GPR40	null	266607(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Yhhu4488 , a novel GPR40 agonist , promotes GLP-1 secretion and exerts anti-diabetic effect in rodent models .
26366943	0	Yohimbine	0,9	5-HT1A	15,21	Yohimbine	5-HT1A	MESH:D015016	24473(Tax:10116)	Chemical	Gene	agonist|nsubj|START_ENTITY agonist|amod|END_ENTITY	Yohimbine is a 5-HT1A agonist in rats in doses exceeding 1mg/kg .
8820174	0	Yohimbine	14,23	growth_hormone	74,88	Yohimbine	growth hormone	MESH:D015016	2688	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|response response|amod|END_ENTITY	The effect of Yohimbine , an alpha2 adrenergic receptor antagonist , on the growth_hormone response to apomorphine in normal subjects .
24299123	0	Yucasin	0,7	YUCCA	33,38	Yucasin	YUCCA	null	829389(Tax:3702)	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Yucasin is a potent inhibitor of YUCCA , a key enzyme in auxin biosynthesis .
10234593	0	Z-321	31,36	prolyl_endopeptidase	69,89	Z-321	prolyl endopeptidase	MESH:C106522	5550	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Pharmacokinetics and safety of Z-321 , a novel specific orally active prolyl_endopeptidase inhibitor , in healthy male volunteers .
9062687	0	Z-321	0,5	prolyl_endopeptidase	9,29	Z-321	prolyl endopeptidase	MESH:C106522	83471(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Z-321 , a prolyl_endopeptidase inhibitor , augments the potentiation of synaptic transmission in rat hippocampal slices .
24724067	0	Z-DEVD-FMK	33,43	caspase-3	4,13	Z-DEVD-FMK	caspase-3	MESH:C110772	836	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	The caspase-3 inhibitor -LRB- peptide Z-DEVD-FMK -RRB- affects the survival and function of platelets in platelet concentrate during storage .
17553617	7	Z-LEHD-FMK	1910,1920	caspase-9	1889,1898	Z-LEHD-FMK	caspase-3	MESH:C403754	836	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	These data show that administration of a selective caspase-9 inhibitor , Z-LEHD-FMK , prior to hypoxia prevents the hypoxia-induced increase in caspase-3 activity and the expression of active caspase-3 protein .
26212861	0	Z-Ligustilide	30,43	HSP70	11,16	Z-Ligustilide	HSP70	CHEBI:68232	266759(Tax:10116)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|compound|END_ENTITY	Protective HSP70 Induction by Z-Ligustilide against Oxygen_Glucose_Deprivation_Injury via Activation of the MAPK Pathway but Not of HSF1 .
16942854	0	Z-Pro-Prolinal	35,49	prolyl_oligopeptidase	2,23	Z-Pro-Prolinal	prolyl oligopeptidase	MESH:C038541	5550	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	A prolyl_oligopeptidase inhibitor , Z-Pro-Prolinal , inhibits glyceraldehyde-3-phosphate_dehydrogenase translocation and production of reactive oxygen species in CV1-P cells exposed to 6-hydroxydopamine .
21820899	0	Z-VAD-FMK	45,54	caspase-6	19,28	Z-VAD-FMK	caspase-6	null	839	Chemical	Gene	complex|nmod|START_ENTITY END_ENTITY|nmod|complex	Structure of human caspase-6 in complex with Z-VAD-FMK : New peptide binding mode observed for the non-canonical caspase conformation .
23038474	0	Z-isochaihulactone	46,64	androgen_receptor	14,31	Z-isochaihulactone	androgen receptor	null	367	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Regulation of androgen_receptor expression by Z-isochaihulactone mediated by the JNK signaling pathway and might be related to cytotoxicity in prostate_cancer .
23441843	0	Z-ligustilide	99,112	Nrf2	27,31	Z-ligustilide	Nrf2	CHEBI:68232	18024(Tax:10090)	Chemical	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	Epigenetic reactivation of Nrf2 in murine prostate_cancer TRAMP_C1 cells by natural phytochemicals Z-ligustilide and Radix angelica sinensis via promoter CpG demethylation .
18854175	0	Z-tLeu-Asp-H	30,42	caspase-3	6,15	Z-tLeu-Asp-H	caspase-3	null	836	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Human caspase-3 inhibition by Z-tLeu-Asp-H : tLeu -LRB- P2 -RRB- counterbalances Asp -LRB- P4 -RRB- and Glu -LRB- P3 -RRB- specific inhibitor truncation .
11012557	0	Z13752A	145,152	ACE	201,204	Z13752A	ACE	null	1636	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	A double-blind , placebo-controlled study to assess tolerability , pharmacokinetics and preliminary pharmacodynamics of single escalating doses of Z13752A , a novel dual inhibitor of the metalloproteases ACE and NEP , in healthy volunteers .
10683191	0	Z13752A	15,22	bradykinin	127,137	Z13752A	bradykinin	null	478666(Tax:9615)	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|role role|nmod|END_ENTITY	The effects of Z13752A , a combined ACE/NEP inhibitor , on responses to coronary_artery_occlusion ; a primary protective role for bradykinin .
18723478	0	Z3	0,2	Jak2	12,16	Z3	Jak2	null	3717	Chemical	Gene	tyrosine|advmod|START_ENTITY tyrosine|nsubj|END_ENTITY	Z3 , a novel Jak2 tyrosine kinase small-molecule inhibitor that suppresses Jak2-mediated pathologic cell growth .
21883534	11	ZAG	1375,1378	WAT	1394,1397	ZAG	ZAG	null	563	Chemical	Gene	secretion|compound|START_ENTITY secretion|nmod|END_ENTITY	In obese subjects on a VLCD , ZAG secretion from WAT increased significantly whereas serum levels remained unaltered .
10545286	0	ZD1611	0,6	endothelin-A_receptor	25,46	ZD1611	endothelin-A receptor	MESH:C121226	24326(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	ZD1611 , an orally active endothelin-A_receptor antagonist , prevents chronic hypoxia-induced pulmonary_hypertension in the rat .
9676649	0	ZD1611	56,62	endothelin-A_receptor	22,43	ZD1611	endothelin-A receptor	MESH:C121226	24326(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	A novel orally active endothelin-A_receptor antagonist , ZD1611 , prevents chronic hypoxia-induced pulmonary_hypertension in the rat .
7577036	0	ZD1694	0,6	thymidylate_synthase	24,44	ZD1694	thymidylate synthase	MESH:C068874	22171(Tax:10090)	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	ZD1694 -LRB- Tomudex -RRB- : a new thymidylate_synthase inhibitor with activity in colorectal_cancer .
8787544	0	ZD1694	101,107	thymidylate_synthase	49,69	ZD1694	thymidylate synthase	MESH:C068874	22171(Tax:10090)	Chemical	Gene	tomudex|appos|START_ENTITY effect|nmod|tomudex dUMP|dep|effect dUMP|nmod|index index|nmod|inhibition inhibition|amod|END_ENTITY	Immunoreactive dUMP and TTP pools as an index of thymidylate_synthase inhibition ; effect of tomudex -LRB- ZD1694 -RRB- and a nonpolyglutamated quinazoline_antifolate -LRB- CB30900 -RRB- in L1210 mouse leukaemia cells .
11156248	0	ZD1839	104,110	EGFR	137,141	ZD1839	EGFR	MESH:C419708	1956	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|kinase kinase|amod|END_ENTITY	Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 -LRB- Iressa -RRB- , an inhibitor of EGFR tyrosine kinase .
11745477	0	ZD1839	0,6	EGFR	59,63	ZD1839	EGFR	MESH:C419708	1956	Chemical	Gene	START_ENTITY|appos|epidermal_growth_factor_receptor epidermal_growth_factor_receptor|appos|END_ENTITY	ZD1839 -LRB- Iressa -RRB- , a novel epidermal_growth_factor_receptor -LRB- EGFR -RRB- tyrosine kinase inhibitor , potently inhibits the growth of EGFR-positive cancer cell lines with or without erbB2 overexpression .
11986789	0	ZD1839	149,155	EGFR	47,51	ZD1839	EGFR	MESH:C419708	1956	Chemical	Gene	effect|nmod|START_ENTITY kinase|nmod|effect kinase|nsubj|Influence Influence|nmod|epidermal_growth_factor_receptor epidermal_growth_factor_receptor|appos|END_ENTITY	Influence of epidermal_growth_factor_receptor -LRB- EGFR -RRB- , p53 and intrinsic MAP kinase pathway status of tumour cells on the antiproliferative effect of ZD1839 -LRB- `` Iressa '' -RRB- .
12573759	0	ZD1839	19,25	EGFR	0,4	ZD1839	EGFR	MESH:C419708	1956	Chemical	Gene	blockade|nmod|START_ENTITY blockade|amod|END_ENTITY	EGFR blockade with ZD1839 -LRB- `` Iressa '' -RRB- potentiates the antitumor effects of single and multiple fractions of ionizing radiation in human A431_squamous_cell_carcinoma .
12684395	0	ZD1839	0,6	EGFR	53,57	ZD1839	EGFR	MESH:C419708	1956	Chemical	Gene	START_ENTITY|appos|epidermal_growth_factor_receptor epidermal_growth_factor_receptor|appos|END_ENTITY	ZD1839 , a specific epidermal_growth_factor_receptor -LRB- EGFR -RRB- tyrosine kinase inhibitor , induces the formation of inactive EGFR/HER2 and EGFR/HER3 heterodimers and prevents heregulin signaling in HER2-overexpressing breast_cancer cells .
14512185	0	ZD1839	90,96	EGFR	144,148	ZD1839	EGFR	MESH:C419708	1956	Chemical	Gene	lines|nmod|START_ENTITY sensitivity|nmod|lines related|nsubjpass|sensitivity related|nmod|expression expression|nmod|END_ENTITY	The sensitivity of lung_cancer cell lines to the EGFR-selective tyrosine kinase inhibitor ZD1839 -LRB- ` Iressa ' -RRB- is not related to the expression of EGFR or HER-2 or to K-ras gene status .
14582710	0	ZD1839	90,96	EGFR	38,42	ZD1839	EGFR	MESH:C419708	1956	Chemical	Gene	Iressa|appos|START_ENTITY gefitinib|dep|Iressa kinase|dobj|gefitinib kinase|nsubj|response response|nmod|tyrosine tyrosine|amod|END_ENTITY	Clinically meaningful response to the EGFR tyrosine kinase inhibitor gefitinib -LRB- ` Iressa ' , ZD1839 -RRB- in non_small_cell_lung_cancer .
14603528	0	ZD1839	151,157	EGFR	119,123	ZD1839	EGFR	MESH:C419708	1956	Chemical	Gene	independent|nsubj|START_ENTITY tyrosine|ccomp|independent tyrosine|nsubj|Inhibition Inhibition|nmod|proliferation proliferation|nmod|apoptosis apoptosis|nmod|cells cells|nmod|epidermal_growth_factor_receptor epidermal_growth_factor_receptor|appos|END_ENTITY	Inhibition of proliferation and induction of apoptosis in breast_cancer cells by the epidermal_growth_factor_receptor -LRB- EGFR -RRB- tyrosine kinase inhibitor ZD1839 -LRB- ` Iressa ' -RRB- is independent of EGFR expression level .
14603528	0	ZD1839	151,157	EGFR	187,191	ZD1839	EGFR	MESH:C419708	1956	Chemical	Gene	independent|nsubj|START_ENTITY independent|nmod|level level|amod|END_ENTITY	Inhibition of proliferation and induction of apoptosis in breast_cancer cells by the epidermal_growth_factor_receptor -LRB- EGFR -RRB- tyrosine kinase inhibitor ZD1839 -LRB- ` Iressa ' -RRB- is independent of EGFR expression level .
15386420	0	ZD1839	115,121	EGFR	34,38	ZD1839	EGFR	MESH:C419708	1956	Chemical	Gene	Iressa|dep|START_ENTITY gefitinib|appos|Iressa markers|nmod|gefitinib Epidermal_growth_factor_receptor|nmod|markers Epidermal_growth_factor_receptor|dobj|molecules molecules|appos|END_ENTITY	Epidermal_growth_factor_receptor -LRB- EGFR -RRB- downstream molecules as response predictive markers for gefitinib -LRB- Iressa , ZD1839 -RRB- in chemotherapy-resistant non-small_cell_lung_cancer .
15492792	0	ZD1839	116,122	EGFR	37,41	ZD1839	EGFR	MESH:C419708	1956	Chemical	Gene	Iressa|appos|START_ENTITY gefitinib|dep|Iressa inhibited|nmod|gefitinib inhibited|nsubjpass|phosphorylation phosphorylation|compound|END_ENTITY	Small_cell_lung_cancer cells express EGFR and tyrosine phosphorylation of EGFR is inhibited by gefitinib -LRB- `` Iressa '' , ZD1839 -RRB- .
15492792	0	ZD1839	116,122	EGFR	74,78	ZD1839	EGFR	MESH:C419708	1956	Chemical	Gene	Iressa|appos|START_ENTITY gefitinib|dep|Iressa inhibited|nmod|gefitinib inhibited|nsubjpass|phosphorylation phosphorylation|nmod|END_ENTITY	Small_cell_lung_cancer cells express EGFR and tyrosine phosphorylation of EGFR is inhibited by gefitinib -LRB- `` Iressa '' , ZD1839 -RRB- .
16487738	0	ZD1839	37,43	EGFR	13,17	ZD1839	EGFR	MESH:C419708	1956	Chemical	Gene	kinase|nmod|START_ENTITY kinase|nsubj|Targeting Targeting|nmod|tyrosine tyrosine|amod|END_ENTITY	Targeting of EGFR tyrosine kinase by ZD1839 -LRB- `` Iressa '' -RRB- in androgen-responsive prostate_cancer in vitro .
16525641	0	ZD1839	15,21	EGFR	51,55	ZD1839	EGFR	MESH:C419708	1956	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	The effects of ZD1839 -LRB- Iressa -RRB- , a highly selective EGFR tyrosine kinase inhibitor , as a radiosensitiser in bile_duct_carcinoma cell lines .
17145836	0	ZD1839	103,109	EGFR	60,64	ZD1839	EGFR	MESH:C419708	1956	Chemical	Gene	gefitinib|appos|START_ENTITY correlates|nsubj|gefitinib tyrosine|ccomp|correlates tyrosine|nsubj|activity activity|nmod|epidermal_growth_factor_receptor epidermal_growth_factor_receptor|appos|END_ENTITY	Antitumor activity of the epidermal_growth_factor_receptor -LRB- EGFR -RRB- tyrosine kinase inhibitor gefitinib -LRB- ZD1839 , Iressa -RRB- in non-small_cell_lung_cancer cell lines correlates with gene copy number and EGFR mutations but not EGFR protein levels .
17609586	0	ZD1839	71,77	EGFR	117,121	ZD1839	EGFR	MESH:C419708	13649(Tax:10090)	Chemical	Gene	Iressa|appos|START_ENTITY radiation|dep|Iressa radiation|appos|inhibitor inhibitor|appos|END_ENTITY	Combination treatment with ionising radiation and gefitinib -LRB- ` Iressa ' , ZD1839 -RRB- , an epidermal_growth_factor_receptor -LRB- EGFR -RRB- inhibitor , significantly inhibits bladder_cancer cell growth in vitro and in vivo .
11751413	0	ZD1839	66,72	Epidermal_growth_factor_receptor	0,32	ZD1839	Epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	inhibits|nsubj|START_ENTITY tyrosine|ccomp|inhibits tyrosine|nsubj|END_ENTITY	Epidermal_growth_factor_receptor -LRB- HER1 -RRB- tyrosine kinase inhibitor ZD1839 -LRB- Iressa -RRB- inhibits HER2/neu -LRB- erbB2 -RRB- - overexpressing breast_cancer cells in vitro and in vivo .
15386420	0	ZD1839	115,121	Epidermal_growth_factor_receptor	0,32	ZD1839	Epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	Iressa|dep|START_ENTITY gefitinib|appos|Iressa markers|nmod|gefitinib END_ENTITY|nmod|markers	Epidermal_growth_factor_receptor -LRB- EGFR -RRB- downstream molecules as response predictive markers for gefitinib -LRB- Iressa , ZD1839 -RRB- in chemotherapy-resistant non-small_cell_lung_cancer .
12684433	0	ZD1839	118,124	cyclooxygenase-2	27,43	ZD1839	cyclooxygenase-2	MESH:C419708	19225(Tax:10090)	Chemical	Gene	inhibitor|nmod|START_ENTITY inhibitor|amod|END_ENTITY	Combination of a selective cyclooxygenase-2 inhibitor with epidermal_growth_factor_receptor tyrosine kinase inhibitor ZD1839 and protein kinase A antisense causes cooperative antitumor and antiangiogenic effect .
11350918	0	ZD1839	81,87	epidermal_growth_factor_receptor	110,142	ZD1839	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	Inhibition|nmod|START_ENTITY tyrosine|advcl|Inhibition tyrosine|nsubj|END_ENTITY	Inhibition of growth factor production and angiogenesis in human cancer cells by ZD1839 -LRB- Iressa -RRB- , a selective epidermal_growth_factor_receptor tyrosine kinase inhibitor .
11459659	0	ZD1839	41,47	epidermal_growth_factor_receptor	86,118	ZD1839	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	identification|nmod|START_ENTITY leading|nmod|identification Studies|amod|leading Studies|dep|inhibitor inhibitor|amod|END_ENTITY	Studies leading to the identification of ZD1839 -LRB- IRESSA -RRB- : an orally active , selective epidermal_growth_factor_receptor tyrosine kinase inhibitor targeted to the treatment of cancer .
11706397	0	ZD1839	92,98	epidermal_growth_factor_receptor	33,65	ZD1839	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	tyrosine|dobj|START_ENTITY tyrosine|nsubj|studies studies|nmod|END_ENTITY	Pharmacodynamic studies with the epidermal_growth_factor_receptor tyrosine kinase inhibitor ZD1839 .
11894012	0	ZD1839	0,6	epidermal_growth_factor_receptor	20,52	ZD1839	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	tyrosine|advmod|START_ENTITY tyrosine|nsubj|END_ENTITY	ZD1839 , a selective epidermal_growth_factor_receptor tyrosine kinase inhibitor , alone and in combination with radiation and chemotherapy as a new therapeutic strategy in non-small_cell_lung_cancer .
11980649	0	ZD1839	0,6	epidermal_growth_factor_receptor	69,101	ZD1839	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|inhibition inhibition|nmod|kinase kinase|compound|END_ENTITY	ZD1839 -LRB- Iressa -RRB- induces antiangiogenic effects through inhibition of epidermal_growth_factor_receptor tyrosine kinase .
11986789	0	ZD1839	149,155	epidermal_growth_factor_receptor	13,45	ZD1839	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	effect|nmod|START_ENTITY kinase|nmod|effect kinase|nsubj|Influence Influence|nmod|END_ENTITY	Influence of epidermal_growth_factor_receptor -LRB- EGFR -RRB- , p53 and intrinsic MAP kinase pathway status of tumour cells on the antiproliferative effect of ZD1839 -LRB- `` Iressa '' -RRB- .
12036427	0	ZD1839	0,6	epidermal_growth_factor_receptor	22,54	ZD1839	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	START_ENTITY|parataxis|targeting targeting|dobj|END_ENTITY	ZD1839 : targeting the epidermal_growth_factor_receptor in cancer therapy .
12154033	0	ZD1839	117,123	epidermal_growth_factor_receptor	70,102	ZD1839	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	angiogenesis|nmod|START_ENTITY angiogenesis|nmod|inhibition inhibition|compound|END_ENTITY	Modulation of radiation response and tumor-induced angiogenesis after epidermal_growth_factor_receptor inhibition by ZD1839 -LRB- Iressa -RRB- .
12207609	0	ZD1839	62,68	epidermal_growth_factor_receptor	99,131	ZD1839	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Follicular and epidermal alterations in patients treated with ZD1839 -LRB- Iressa -RRB- , an inhibitor of the epidermal_growth_factor_receptor .
12228201	0	ZD1839	74,80	epidermal_growth_factor_receptor	15,47	ZD1839	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	well-tolerated|nsubj|START_ENTITY tyrosine|ccomp|well-tolerated tyrosine|nsubj|END_ENTITY	Selective oral epidermal_growth_factor_receptor tyrosine kinase inhibitor ZD1839 is generally well-tolerated and has activity in non-small-cell_lung_cancer and other solid tumors : results of a phase I trial .
12599217	0	ZD1839	82,88	epidermal_growth_factor_receptor	104,136	ZD1839	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|inhibitor inhibitor|amod|tyrosine tyrosine|amod|END_ENTITY	Critical role of both p27KIP1 and p21CIP1/WAF1 in the antiproliferative effect of ZD1839 -LRB- ` Iressa ' -RRB- , an epidermal_growth_factor_receptor tyrosine kinase inhibitor , in head and neck squamous_carcinoma cells .
12700278	0	ZD1839	192,198	epidermal_growth_factor_receptor	15,47	ZD1839	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	Suppression|nmod|START_ENTITY Suppression|nmod|END_ENTITY	Suppression of epidermal_growth_factor_receptor , mitogen-activated protein kinase , and Pak1 pathways and invasiveness of human cutaneous_squamous_cancer cells by the tyrosine kinase inhibitor ZD1839 -LRB- Iressa -RRB- .
12796031	0	ZD1839	132,138	epidermal_growth_factor_receptor	52,84	ZD1839	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	Iressa|appos|START_ENTITY gefitinib|dep|Iressa tyrosine|dobj|gefitinib tyrosine|csubj|Phase Phase|xcomp|trial trial|nmod|END_ENTITY	Phase I pharmacokinetic trial of the selective oral epidermal_growth_factor_receptor tyrosine kinase inhibitor gefitinib -LRB- ` Iressa ' , ZD1839 -RRB- in Japanese patients with solid malignant_tumors .
12813135	0	ZD1839	0,6	epidermal_growth_factor_receptor	20,52	ZD1839	epidermal growth factor receptor	MESH:C419708	13649(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	ZD1839 , a selective epidermal_growth_factor_receptor tyrosine kinase inhibitor , shows antimetastatic activity using a hepatocellular_carcinoma model .
12824893	0	ZD1839	160,166	epidermal_growth_factor_receptor	101,133	ZD1839	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	START_ENTITY|amod|tyrosine tyrosine|amod|END_ENTITY	A report of two bronchioloalveolar_carcinoma cases which were rapidly improved by treatment with the epidermal_growth_factor_receptor tyrosine kinase inhibitor ZD1839 -LRB- `` Iressa '' -RRB- .
12855618	0	ZD1839	90,96	epidermal_growth_factor_receptor	31,63	ZD1839	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	tyrosine|dobj|START_ENTITY tyrosine|nsubj|study study|nmod|END_ENTITY	A pharmacodynamic study of the epidermal_growth_factor_receptor tyrosine kinase inhibitor ZD1839 in metastatic colorectal_cancer patients .
14583782	1	ZD1839	139,145	epidermal_growth_factor_receptor	92,124	ZD1839	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	gefitinib|appos|START_ENTITY Targeting|nmod|gefitinib Targeting|dobj|END_ENTITY	Targeting the epidermal_growth_factor_receptor by gefitinib -LRB- ZD1839 -RRB- .
14603528	0	ZD1839	151,157	epidermal_growth_factor_receptor	85,117	ZD1839	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	independent|nsubj|START_ENTITY tyrosine|ccomp|independent tyrosine|nsubj|Inhibition Inhibition|nmod|proliferation proliferation|nmod|apoptosis apoptosis|nmod|cells cells|nmod|END_ENTITY	Inhibition of proliferation and induction of apoptosis in breast_cancer cells by the epidermal_growth_factor_receptor -LRB- EGFR -RRB- tyrosine kinase inhibitor ZD1839 -LRB- ` Iressa ' -RRB- is independent of EGFR expression level .
14662414	0	ZD1839	21,27	epidermal_growth_factor_receptor	33,65	ZD1839	epidermal growth factor receptor	MESH:C419708	13649(Tax:10090)	Chemical	Gene	Iressa|appos|START_ENTITY Gefitinib|dep|Iressa Gefitinib|appos|inhibitor inhibitor|amod|END_ENTITY	Gefitinib -LRB- ` Iressa ' , ZD1839 -RRB- , an epidermal_growth_factor_receptor tyrosine kinase inhibitor , up-regulates p27KIP1 and induces G1_arrest in oral_squamous_cell_carcinoma cell lines .
14679116	0	ZD1839	53,59	epidermal_growth_factor_receptor	65,97	ZD1839	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	Iressa|dep|START_ENTITY Activity|appos|Iressa Activity|nmod|END_ENTITY	Activity of a specific inhibitor , gefitinib -LRB- Iressa , ZD1839 -RRB- , of epidermal_growth_factor_receptor in refractory_non-small-cell_lung_cancer .
14710235	0	ZD1839	112,118	epidermal_growth_factor_receptor	34,66	ZD1839	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	Iressa|dep|START_ENTITY gefitinib|appos|Iressa tyrosine|dobj|gefitinib tyrosine|nsubj|effect effect|nmod|END_ENTITY	Additive antitumour effect of the epidermal_growth_factor_receptor tyrosine kinase inhibitor gefitinib -LRB- Iressa , ZD1839 -RRB- and the antioestrogen fulvestrant -LRB- Faslodex , ICI_182 ,780 -RRB- in breast_cancer cells .
14713849	0	ZD1839	111,117	epidermal_growth_factor_receptor	64,96	ZD1839	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	induced|nmod|START_ENTITY induced|nmod|inhibition inhibition|compound|END_ENTITY	Modulation of tumor growth and tumor induced angiogenesis after epidermal_growth_factor_receptor inhibition by ZD1839 in renal_cell_carcinoma .
14987267	0	ZD1839	31,37	epidermal_growth_factor_receptor	59,91	ZD1839	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Acneiform_lesions secondary to ZD1839 , an inhibitor of the epidermal_growth_factor_receptor .
15187994	0	ZD1839	116,122	epidermal_growth_factor_receptor	12,44	ZD1839	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	Iressa|appos|START_ENTITY Analysis|dep|Iressa Analysis|nmod|expression expression|compound|END_ENTITY	Analysis of epidermal_growth_factor_receptor expression as a predictive factor for response to gefitinib -LRB- ` Iressa ' , ZD1839 -RRB- in non-small-cell_lung_cancer .
15299080	0	ZD1839	95,101	epidermal_growth_factor_receptor	106,138	ZD1839	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	tyrosine|advcl|START_ENTITY tyrosine|nsubj|END_ENTITY	Antitumor activity of ZD6126 , a novel vascular-targeting agent , is enhanced when combined with ZD1839 , an epidermal_growth_factor_receptor tyrosine kinase inhibitor , and potentiates the effects of radiation in a human non-small cell lung_cancer xenograft model .
15475435	0	ZD1839	140,146	epidermal_growth_factor_receptor	86,118	ZD1839	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	gefitinib|appos|START_ENTITY gefitinib|amod|vitro vitro|nmod|inhibitor inhibitor|compound|END_ENTITY	Modulation of DNA repair in vitro after treatment with chemotherapeutic agents by the epidermal_growth_factor_receptor inhibitor gefitinib -LRB- ZD1839 -RRB- .
15475436	0	ZD1839	98,104	epidermal_growth_factor_receptor	9,41	ZD1839	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	gefitinib|appos|START_ENTITY END_ENTITY|nmod|gefitinib	Combined epidermal_growth_factor_receptor targeting with the tyrosine kinase inhibitor gefitinib -LRB- ZD1839 -RRB- and the monoclonal antibody cetuximab -LRB- IMC-C225 -RRB- : superiority over single-agent receptor targeting .
15688060	0	ZD1839	144,150	epidermal_growth_factor_receptor	64,96	ZD1839	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	Iressa|appos|START_ENTITY gefitinib|dep|Iressa gefitinib|amod|tyrosine tyrosine|amod|END_ENTITY	Ocular findings in patients with solid tumours treated with the epidermal_growth_factor_receptor tyrosine kinase inhibitor gefitinib -LRB- ` Iressa ' , ZD1839 -RRB- in Phase I and II clinical trials .
15735043	0	ZD1839	21,27	epidermal_growth_factor_receptor	33,65	ZD1839	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	Iressa|appos|START_ENTITY Gefitinib|dep|Iressa Gefitinib|appos|inhibitor inhibitor|amod|END_ENTITY	Gefitinib -LRB- `` Iressa '' , ZD1839 -RRB- , an epidermal_growth_factor_receptor tyrosine kinase inhibitor , reverses breast_cancer_resistance_protein / ABCG2-mediated drug resistance .
15753373	0	ZD1839	120,126	epidermal_growth_factor_receptor	69,101	ZD1839	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	Iressa|appos|START_ENTITY Multidrug|nsubj|Iressa Multidrug|dep|prevents prevents|dobj|death death|acl|induced induced|nmod|inhibitor inhibitor|compound|END_ENTITY	Multidrug transporter ABCG2 prevents tumor cell death induced by the epidermal_growth_factor_receptor inhibitor Iressa -LRB- ZD1839 , Gefitinib -RRB- .
17145836	0	ZD1839	103,109	epidermal_growth_factor_receptor	26,58	ZD1839	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	gefitinib|appos|START_ENTITY correlates|nsubj|gefitinib tyrosine|ccomp|correlates tyrosine|nsubj|activity activity|nmod|END_ENTITY	Antitumor activity of the epidermal_growth_factor_receptor -LRB- EGFR -RRB- tyrosine kinase inhibitor gefitinib -LRB- ZD1839 , Iressa -RRB- in non-small_cell_lung_cancer cell lines correlates with gene copy number and EGFR mutations but not EGFR protein levels .
17236550	0	ZD1839	92,98	epidermal_growth_factor_receptor	33,65	ZD1839	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	tyrosine|dobj|START_ENTITY tyrosine|nsubj|study study|nmod|effect effect|nmod|END_ENTITY	-LSB- Experimental study of effect of epidermal_growth_factor_receptor tyrosine kinase inhibitor ZD1839 in combination with irinotecan -RSB- .
17289870	0	ZD1839	72,78	epidermal_growth_factor_receptor	84,116	ZD1839	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	Iressa|dep|START_ENTITY gefitinib|appos|Iressa Proteomic|nmod|gefitinib tyrosine|advcl|Proteomic tyrosine|nsubj|END_ENTITY	Proteomic signature corresponding to the response to gefitinib -LRB- Iressa , ZD1839 -RRB- , an epidermal_growth_factor_receptor tyrosine kinase inhibitor in lung_adenocarcinoma .
17609586	0	ZD1839	71,77	epidermal_growth_factor_receptor	83,115	ZD1839	epidermal growth factor receptor	MESH:C419708	13649(Tax:10090)	Chemical	Gene	Iressa|appos|START_ENTITY radiation|dep|Iressa radiation|appos|inhibitor inhibitor|compound|END_ENTITY	Combination treatment with ionising radiation and gefitinib -LRB- ` Iressa ' , ZD1839 -RRB- , an epidermal_growth_factor_receptor -LRB- EGFR -RRB- inhibitor , significantly inhibits bladder_cancer cell growth in vitro and in vivo .
12599217	0	ZD1839	82,88	p27KIP1	22,29	ZD1839	p27KIP1	MESH:C419708	1027	Chemical	Gene	effect|nmod|START_ENTITY role|nmod|effect role|nmod|END_ENTITY	Critical role of both p27KIP1 and p21CIP1/WAF1 in the antiproliferative effect of ZD1839 -LRB- ` Iressa ' -RRB- , an epidermal_growth_factor_receptor tyrosine kinase inhibitor , in head and neck squamous_carcinoma cells .
19414361	0	ZD1839	0,6	p27Kip1	27,34	ZD1839	p27Kip1	MESH:C419708	1027	Chemical	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	ZD1839 -LRB- IRESSA -RRB- stabilizes p27Kip1 and enhances radiosensitivity in cholangiocarcinoma cell lines .
18616419	0	ZD4054	0,6	endothelin_A	19,31	ZD4054	endothelin A	MESH:C511404	1909	Chemical	Gene	START_ENTITY|dep|antagonist antagonist|compound|END_ENTITY	ZD4054 : a specific endothelin_A receptor antagonist with promising activity in metastatic castration-resistant prostate_cancer .
17620430	0	ZD4054	0,6	endothelin_A_receptor	37,58	ZD4054	endothelin A receptor	MESH:C511404	1909	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|nmod|END_ENTITY	ZD4054 , a specific antagonist of the endothelin_A_receptor , inhibits tumor growth and enhances paclitaxel activity in human ovarian_carcinoma in vitro and in vivo .
21657967	0	ZD4054	46,52	endothelin_A_receptor	72,93	ZD4054	endothelin A receptor	MESH:C511404	13617(Tax:10090)	Chemical	Gene	zibotentan|appos|START_ENTITY disposition|nmod|zibotentan disposition|dep|antagonist antagonist|compound|END_ENTITY	The disposition and metabolism of zibotentan -LRB- ZD4054 -RRB- : an oral-specific endothelin_A_receptor antagonist in mice , rats and dogs .
10706112	0	ZD4190	0,6	vascular_endothelial_growth_factor	38,72	ZD4190	vascular endothelial growth factor	MESH:C405268	7422	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	ZD4190 : an orally active inhibitor of vascular_endothelial_growth_factor signaling with broad-spectrum antitumor efficacy .
16928828	0	ZD4190	154,160	vascular_endothelial_growth_factor	14,48	ZD4190	vascular endothelial growth factor	MESH:C405268	7422	Chemical	Gene	-165|nmod|START_ENTITY -165|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of vascular_endothelial_growth_factor -LRB- VEGF -RRB- -165 and semaphorin_3A-mediated cellular invasion and tumor growth by the VEGF signaling inhibitor ZD4190 in human colon_cancer cells and xenografts .
9756985	0	ZD6169	11,17	c-fos	78,83	ZD6169	c-fos	MESH:C095007	314322(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effects of ZD6169 , a KATP channel opener , on bladder_hyperactivity and spinal c-fos expression evoked by bladder_irritation in rats .
17631646	0	ZD6474	88,94	EGFR	167,171	ZD6474	EGFR	MESH:C452423	1956	Chemical	Gene	Induction|nmod|START_ENTITY kinase|advcl|Induction kinase|nmod|activity activity|nmod|kinase kinase|amod|END_ENTITY	Induction of cell cycle arrest and apoptosis in human nasopharyngeal_carcinoma cells by ZD6474 , an inhibitor of VEGFR tyrosine kinase with additional activity against EGFR tyrosine kinase .
20139705	0	ZD6474	0,6	EGFR	44,48	ZD6474	EGFR	MESH:C452423	1956	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	ZD6474 , a dual tyrosine kinase inhibitor of EGFR and VEGFR-2 , inhibits MAPK/ERK and AKT/PI3-K and induces apoptosis in breast_cancer cells .
24138843	0	ZD6474	46,52	EGFR	25,29	ZD6474	EGFR	MESH:C452423	1956	Chemical	Gene	using|dobj|START_ENTITY therapy|acl|using therapy|nmod|END_ENTITY	Targeted therapy against EGFR and VEGFR using ZD6474 enhances the therapeutic potential of UV-B phototherapy in breast_cancer cells .
14612898	0	ZD6474	70,76	VEGF	80,84	ZD6474	VEGF	MESH:C452423	22339(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Use of dynamic contrast-enhanced MRI to evaluate acute treatment with ZD6474 , a VEGF signalling inhibitor , in PC-3_prostate_tumours .
15596048	0	ZD6474	22,28	VEGF	32,36	ZD6474	VEGF	MESH:C452423	22339(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Anticancer effects of ZD6474 , a VEGF receptor tyrosine kinase inhibitor , in gefitinib -LRB- `` Iressa '' -RRB- - sensitive and resistant xenograft models .
15886878	0	ZD6474	45,51	VEGF	4,8	ZD6474	VEGF	MESH:C452423	22339(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	The VEGF receptor tyrosine kinase inhibitor , ZD6474 , inhibits angiogenesis and affects microvascular architecture within an orthotopically implanted renal_cell_carcinoma .
15905307	0	ZD6474	23,29	VEGF	61,65	ZD6474	VEGF	MESH:C452423	7422	Chemical	Gene	evaluation|nmod|START_ENTITY evaluation|appos|inhibitor inhibitor|nmod|signaling signaling|compound|END_ENTITY	Clinical evaluation of ZD6474 , an orally active inhibitor of VEGF and EGF receptor signaling , in patients with solid , malignant_tumors .
16140331	0	ZD6474	15,21	VEGF	39,43	ZD6474	VEGF	MESH:C452423	22339(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|signaling signaling|compound|END_ENTITY	The effects of ZD6474 , an inhibitor of VEGF signaling , on cutaneous wound healing in mice .
19528456	0	ZD6474	85,91	VEGF	21,25	ZD6474	VEGF	MESH:C452423	7422	Chemical	Gene	ZACTIMA|dep|START_ENTITY vandetanib|appos|ZACTIMA efficacy|nmod|vandetanib END_ENTITY|nmod|efficacy	Impact of tumor cell VEGF expression on the in vivo efficacy of vandetanib -LRB- ZACTIMA ; ZD6474 -RRB- .
15928657	0	ZD6474	0,6	VEGFR	29,34	ZD6474	VEGFR	MESH:C452423	3791	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	ZD6474 -- a novel inhibitor of VEGFR and EGFR tyrosine kinase activity .
16377413	0	ZD6474	0,6	VEGFR	24,29	ZD6474	VEGFR	MESH:C452423	3791	Chemical	Gene	tyrosine|advmod|START_ENTITY tyrosine|nsubj|inhibitor inhibitor|nmod|END_ENTITY	ZD6474 , an inhibitor of VEGFR and EGFR tyrosine kinase activity in combination with radiotherapy .
16891475	0	ZD6474	127,133	VEGFR	161,166	ZD6474	VEGFR	MESH:C452423	3791	Chemical	Gene	combination|nmod|START_ENTITY oxaliplatin|nmod|combination inhibition|acl:relcl|oxaliplatin tyrosine|nsubj|inhibition tyrosine|nsubj|inhibitor inhibitor|nmod|END_ENTITY	Sequence-dependent inhibition of human colon_cancer cell growth and of prosurvival pathways by oxaliplatin in combination with ZD6474 -LRB- Zactima -RRB- , an inhibitor of VEGFR and EGFR tyrosine kinases .
17393165	0	ZD6474	81,87	VEGFR	28,33	ZD6474	VEGFR	MESH:C452423	3791	Chemical	Gene	vandetanib|appos|START_ENTITY kinase|dobj|vandetanib kinase|nsubj|scheduling scheduling|nmod|END_ENTITY	Dose scheduling of the dual VEGFR and EGFR tyrosine kinase inhibitor vandetanib -LRB- ZD6474 , Zactima -RRB- in combination with radiotherapy in EGFR-positive and EGFR-null human head_and_neck_tumor xenografts .
17631646	0	ZD6474	88,94	VEGFR	112,117	ZD6474	VEGFR	MESH:C452423	3791	Chemical	Gene	Induction|nmod|START_ENTITY kinase|advcl|Induction kinase|nsubj|inhibitor inhibitor|nmod|tyrosine tyrosine|amod|END_ENTITY	Induction of cell cycle arrest and apoptosis in human nasopharyngeal_carcinoma cells by ZD6474 , an inhibitor of VEGFR tyrosine kinase with additional activity against EGFR tyrosine kinase .
17889445	0	ZD6474	45,51	VEGFR	25,30	ZD6474	VEGFR	MESH:C452423	3791	Chemical	Gene	therapy|nmod|START_ENTITY therapy|nmod|END_ENTITY	Targeted therapy against VEGFR and EGFR with ZD6474 enhances the therapeutic efficacy of irradiation in an orthotopic model of human non-small-cell lung_cancer .
19319137	0	ZD6474	12,18	VEGFR	37,42	ZD6474	VEGFR	MESH:C452423	3791	Chemical	Gene	Vandetanib|appos|START_ENTITY Vandetanib|appos|inhibitor inhibitor|nmod|END_ENTITY	Vandetanib -LRB- ZD6474 -RRB- , an inhibitor of VEGFR and EGFR signalling , as a novel molecular-targeted therapy against cholangiocarcinoma .
17671152	0	ZD6474	83,89	Vascular_endothelial_growth_factor	0,34	ZD6474	Vascular endothelial growth factor	MESH:C452423	7422	Chemical	Gene	vandetanib|appos|START_ENTITY inhibitors|dobj|vandetanib inhibitors|nsubj|kinase kinase|compound|END_ENTITY	Vascular_endothelial_growth_factor receptor tyrosine kinase inhibitors vandetanib -LRB- ZD6474 -RRB- and AZD2171 in lung_cancer .
12684431	0	ZD6474	21,27	vascular_endothelial_growth_factor	46,80	ZD6474	vascular endothelial growth factor	MESH:C452423	7422	Chemical	Gene	START_ENTITY|appos|receptor receptor|compound|END_ENTITY	Antitumor effects of ZD6474 , a small molecule vascular_endothelial_growth_factor receptor tyrosine kinase inhibitor , with additional activity against epidermal_growth_factor_receptor tyrosine kinase .
14760102	0	ZD6474	22,28	vascular_endothelial_growth_factor	32,66	ZD6474	vascular endothelial growth factor	MESH:C452423	22339(Tax:10090)	Chemical	Gene	START_ENTITY|appos|receptor receptor|compound|END_ENTITY	Antitumor activity of ZD6474 , a vascular_endothelial_growth_factor receptor tyrosine kinase inhibitor , in human cancer cells with acquired resistance to antiepidermal_growth_factor_receptor therapy .
15367698	0	ZD6474	0,6	vascular_endothelial_growth_factor	10,44	ZD6474	vascular endothelial growth factor	MESH:C452423	7422	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	ZD6474 , a vascular_endothelial_growth_factor receptor tyrosine kinase inhibitor with additional activity against epidermal_growth_factor receptor tyrosine kinase , inhibits orthotopic growth and angiogenesis of gastric_cancer .
15623642	0	ZD6474	0,6	vascular_endothelial_growth_factor	30,64	ZD6474	vascular endothelial growth factor	MESH:C452423	7422	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|signaling signaling|compound|END_ENTITY	ZD6474 , a potent inhibitor of vascular_endothelial_growth_factor signaling , combined with radiotherapy : schedule-dependent enhancement of antitumor activity .
17145834	0	ZD6474	34,40	vascular_endothelial_growth_factor	58,92	ZD6474	vascular endothelial growth factor	MESH:C452423	7422	Chemical	Gene	activity|nmod|START_ENTITY activity|appos|inhibitor inhibitor|nmod|receptor receptor|compound|END_ENTITY	Synergistic antitumor activity of ZD6474 , an inhibitor of vascular_endothelial_growth_factor receptor and epidermal_growth_factor_receptor signaling , with gemcitabine and ionizing radiation against pancreatic_cancer .
15867237	0	ZD6474	32,38	vascular_endothelial_growth_factor_receptor-2	42,87	ZD6474	vascular endothelial growth factor receptor-2	MESH:C452423	3791	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	A multicenter phase II trial of ZD6474 , a vascular_endothelial_growth_factor_receptor-2 and epidermal_growth_factor_receptor tyrosine kinase inhibitor , in patients with previously treated metastatic breast_cancer .
15867254	0	ZD6474	80,86	vascular_endothelial_growth_factor_receptor-2	24,69	ZD6474	vascular endothelial growth factor receptor-2	MESH:C452423	16542(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Differential effects of vascular_endothelial_growth_factor_receptor-2 inhibitor ZD6474 on circulating endothelial progenitors and mature circulating endothelial cells : implications for use as a surrogate marker of antiangiogenic activity .
9653893	0	ZD7114	11,17	beta3-adrenoceptor	31,49	ZD7114	beta3-adrenoceptor	MESH:C071909	25645(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|agonist agonist|amod|END_ENTITY	Effects of ZD7114 , a selective beta3-adrenoceptor agonist , on neuroendocrine mechanisms controlling energy balance .
9797176	0	ZD7155	22,28	angiotensin_II	33,47	ZD7155	angiotensin II	MESH:C095905	24179(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|antagonist antagonist|amod|END_ENTITY	Hypotensive effect of ZD7155 , an angiotensin_II receptor antagonist , parallels receptor occupancy in two-kidney , one-clip Goldblatt hypertensive rats .
9593069	0	ZD7155	57,63	renin	105,110	ZD7155	renin	MESH:C095905	24715(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|regulation regulation|nmod|secretion secretion|compound|END_ENTITY	Effects of the angiotensin_II type-1 receptor antagonist ZD7155 on angiotensin_II-mediated regulation of renin secretion and renal renin gene expression , renal vasoconstriction , and blood pressure in rats .
11555611	0	ZD9331	41,47	thymidylate_synthase	84,104	ZD9331	thymidylate synthase	MESH:C094299	22171(Tax:10090)	Chemical	Gene	study|nmod|START_ENTITY study|appos|inhibitor inhibitor|nmod|END_ENTITY	Pharmacokinetic/pharmacodynamic study of ZD9331 , a nonpolyglutamatable inhibitor of thymidylate_synthase , in a murine model following two curative administration schedules .
12871787	0	ZD_1839	53,60	Epidermal_growth_factor_receptor	0,32	ZD 1839	Epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	targeted|nmod|START_ENTITY targeted|nsubj|END_ENTITY	Epidermal_growth_factor_receptor targeted therapy by ZD_1839 -LRB- Iressa -RRB- in patients with brain metastases from non-small_cell_lung_cancer -LRB- NSCLC -RRB- .
12361698	0	ZD_7114	57,64	beta3_adrenoreceptor	27,47	ZD 7114	beta3 adrenoreceptor	MESH:C071909	25645(Tax:10116)	Chemical	Gene	agonists|dobj|START_ENTITY agonists|nsubj|effect effect|nmod|END_ENTITY	Gastroprotective effect of beta3_adrenoreceptor agonists ZD_7114 and CGP_12177A in rats .
24587682	0	ZD_7288	0,7	HCN	12,15	ZD 7288	HCN	MESH:C082246	85259(Tax:10116)	Chemical	Gene	START_ENTITY|appos|blocker blocker|compound|END_ENTITY	ZD_7288 , an HCN channel blocker , attenuates chronic visceral_pain in irritable_bowel_syndrome-like rats .
22870296	0	ZEL-H16	39,46	histamine_H3_receptor	73,94	ZEL-H16	histamine H3 receptor	MESH:C578331	11255	Chemical	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification and characterization of ZEL-H16 as a novel agonist of the histamine_H3_receptor .
7659950	0	ZENECA_ZD8731	15,28	angiotensin_II	33,47	ZENECA ZD8731	angiotensin II	MESH:C081112	24179(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	The effects of ZENECA_ZD8731 , an angiotensin_II antagonist , on renin expression by juxtaglomerular cells in the rat : comparison of protein and mRNA expression as detected by immunohistochemistry and in situ hybridization .
7659950	0	ZENECA_ZD8731	15,28	renin	63,68	ZENECA ZD8731	renin	MESH:C081112	24715(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|compound|END_ENTITY	The effects of ZENECA_ZD8731 , an angiotensin_II antagonist , on renin expression by juxtaglomerular cells in the rat : comparison of protein and mRNA expression as detected by immunohistochemistry and in situ hybridization .
17334518	0	ZK-807834	74,83	factor-Xa	48,57	ZK-807834	factor-Xa	MESH:C114592	2159	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Potent arterial antithrombotic effect of direct factor-Xa inhibition with ZK-807834 administered to coronary_artery_disease patients .
10813384	0	ZK-807834	11,20	factor_Xa	43,52	ZK-807834	factor Xa	MESH:C114592	2159	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Effects of ZK-807834 , a novel inhibitor of factor_Xa , on arterial and venous_thrombosis in rabbits .
11803247	0	ZK-807834	90,99	factor_Xa	117,126	ZK-807834	factor Xa	MESH:C114592	2159	Chemical	Gene	CI-1031|appos|START_ENTITY CI-1031|appos|inhibitor inhibitor|compound|END_ENTITY	Assessment of ex vivo pharmacodynamic markers during inhibition of thrombosis by CI-1031 -LRB- ZK-807834 -RRB- , a novel direct factor_Xa inhibitor .
17671160	0	ZK-thiazolidinone	32,49	Plk1	17,21	ZK-thiazolidinone	Plk1	MESH:C524394	5347	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|END_ENTITY	Use of the novel Plk1 inhibitor ZK-thiazolidinone to elucidate functions of Plk1 in early and late stages of mitosis .
15668194	0	ZK4044	54,60	PAI-1	37,42	ZK4044	PAI-1	MESH:C502734	5054	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Characterization of a small molecule PAI-1 inhibitor , ZK4044 .
11899248	0	ZK_807834	38,47	factor_Xa	17,26	ZK 807834	factor Xa	MESH:C114592	2159	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Discovery of the factor_Xa inhibitor , ZK_807834 -LRB- CI-1031 -RRB- .
15956248	0	ZM336372	0,8	Raf-1	12,17	ZM336372	Raf-1	MESH:C121825	5894	Chemical	Gene	START_ENTITY|appos|activator activator|compound|END_ENTITY	ZM336372 , a Raf-1 activator , suppresses growth and neuroendocrine hormone levels in carcinoid_tumor cells .
16603190	0	ZM336372	0,8	Raf-1	12,17	ZM336372	Raf-1	MESH:C121825	5894	Chemical	Gene	START_ENTITY|appos|activator activator|compound|END_ENTITY	ZM336372 , a Raf-1 activator , inhibits growth of pheochromocytoma cells .
18299943	0	ZM336372	0,8	Raf-1	12,17	ZM336372	Raf-1	MESH:C121825	5894	Chemical	Gene	START_ENTITY|appos|activator activator|compound|END_ENTITY	ZM336372 , a Raf-1 activator , causes suppression of proliferation in a human hepatocellular_carcinoma cell line .
19182393	0	ZSTK474	10,17	DNA-dependent_protein_kinase	71,99	ZSTK474	DNA-dependent protein kinase	MESH:C510150	5591	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of ZSTK474 , a novel phosphatidylinositol 3-kinase inhibitor , on DNA-dependent_protein_kinase .
21993922	0	ZSTK474	0,7	PI3K	11,15	ZSTK474	PI3K	MESH:C510150	5293	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	ZSTK474 , a PI3K inhibitor , suppresses proliferation and sensitizes human pancreatic_adenocarcinoma cells to gemcitabine .
16622124	0	ZSTK474	22,29	phosphatidylinositol_3-kinase	37,66	ZSTK474	phosphatidylinositol 3-kinase	MESH:C510150	5293	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Antitumor activity of ZSTK474 , a new phosphatidylinositol_3-kinase inhibitor .
20729870	0	ZSTK474	0,7	phosphatidylinositol_3-kinase	17,46	ZSTK474	phosphatidylinositol 3-kinase	MESH:C510150	5293	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	ZSTK474 , a novel phosphatidylinositol_3-kinase inhibitor identified using the JFCR39 drug discovery system .
1594653	0	Zacopride	0,9	5-HT3_receptor	13,27	Zacopride	5-HT3 receptor	MESH:C055971	79246(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Zacopride , a 5-HT3_receptor antagonist , reduces voluntary_ethanol_consumption in rats .
15918777	0	Zanamivir	0,9	neuraminidase	30,43	Zanamivir	neuraminidase	MESH:D053243	4758	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Zanamivir : an influenza virus neuraminidase inhibitor .
1732548	0	Zatosetron	0,10	5HT3_receptor	49,62	Zatosetron	5HT3 receptor	MESH:C064877	79246(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Zatosetron , a potent , selective , and long-acting 5HT3_receptor antagonist : synthesis and structure-activity relationships .
21787672	0	Zearalenone	0,11	pregnane_X_receptor	22,41	Zearalenone	pregnane X receptor	MESH:D015025	8856	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Zearalenone activates pregnane_X_receptor , constitutive_androstane_receptor and aryl_hydrocarbon_receptor and corresponding phase I target genes mRNA in primary cultures of human hepatocytes .
25688362	0	Zeaxanthin	0,10	VEGF	36,40	Zeaxanthin	VEGF	MESH:C005881	7422	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|amod|END_ENTITY	Zeaxanthin inhibits hypoxia-induced VEGF secretion by RPE cells through decreased protein levels of hypoxia-inducible factors-1a .
22065925	0	Zebularine	0,10	MeCP2	109,114	Zebularine	MeCP2	MESH:C009131	4204	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	Zebularine suppresses TGF-beta-induced lens epithelial cell-myofibroblast transdifferentiation by inhibiting MeCP2 .
21673905	0	Zeranol	0,7	p53	23,26	Zeranol	p53	MESH:D015029	7157	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Zeranol down-regulates p53 expression in primary cultured human breast_cancer epithelial cells through epigenetic modification .
23053663	0	Zerumbone	0,9	Bax	17,20	Zerumbone	Bax	MESH:C403304	581	Chemical	Gene	causes|nsubj|START_ENTITY causes|dobj|apoptosis apoptosis|amod|END_ENTITY	Zerumbone causes Bax - and Bak-mediated apoptosis in human breast_cancer cells and inhibits orthotopic xenograft growth in vivo .
25269647	0	Zerumbone	0,9	CD44	33,37	Zerumbone	CD44	MESH:C403304	960	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Zerumbone suppresses EGF-induced CD44 expression through the inhibition of STAT3 in breast_cancer cells .
25573403	0	Zerumbone	0,9	Th1	23,26	Zerumbone	Th1	MESH:C403304	57314(Tax:10090)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|response response|amod|END_ENTITY	Zerumbone enhances the Th1 response and ameliorates ovalbumin-induced Th2 responses and airway inflammation in mice .
21367956	0	Zerumbone	0,9	heme_oxygenase-1	18,34	Zerumbone	heme oxygenase-1	MESH:C403304	15368(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Zerumbone induces heme_oxygenase-1 expression in mouse skin and cultured murine epidermal cells through activation of Nrf2 .
22330084	0	Zerumbone	0,9	interleukin-6	19,32	Zerumbone	interleukin-6	MESH:C403304	3569	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Zerumbone inhibits interleukin-6 and induces apoptosis and cell cycle arrest in ovarian_and_cervical_cancer cells .
2473929	0	Zhi-mu_saponin	0,14	alpha-fetoprotein	24,41	Zhi-mu saponin	alpha-fetoprotein	MESH:C060637	24177(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Zhi-mu_saponin inhibits alpha-fetoprotein gene expression in developing rat liver .
26235588	0	Zileuton	29,37	5-Lipoxygenase	4,18	Zileuton	5-Lipoxygenase	MESH:C063449	11689(Tax:10090)	Chemical	Gene	Neuroprotection|compound|START_ENTITY Neuroprotection|amod|END_ENTITY	The 5-Lipoxygenase Inhibitor Zileuton Confers Neuroprotection against Glutamate Oxidative Damage by Inhibiting Ferroptosis .
12949886	0	Zileuton	0,8	5-lipoxygenase	12,26	Zileuton	5-lipoxygenase	MESH:C063449	240	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Zileuton , a 5-lipoxygenase inhibitor , increases production of thromboxane_A2 and platelet_aggregation in patients with asthma .
1334515	0	Zileuton	0,8	5-lipoxygenase	12,26	Zileuton	5-lipoxygenase	MESH:C063449	240	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Zileuton , a 5-lipoxygenase inhibitor in rheumatoid_arthritis .
1475235	0	Zileuton	41,49	5-lipoxygenase	60,74	Zileuton	5-lipoxygenase	MESH:C063449	240	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Kinetics and mechanism of degradation of Zileuton , a potent 5-lipoxygenase inhibitor .
15604543	0	Zileuton	0,8	5-lipoxygenase	18,32	Zileuton	5-lipoxygenase	MESH:C063449	240	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Zileuton , an oral 5-lipoxygenase inhibitor , directly reduces sebum production .
1665285	0	Zileuton	10,18	5-lipoxygenase	36,50	Zileuton	5-lipoxygenase	MESH:C063449	240	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	Effect of Zileuton -LRB- A-64077 -RRB- on the 5-lipoxygenase activity of human whole blood ex vivo .
8826571	0	Zileuton	0,8	5-lipoxygenase	20,34	Zileuton	5-lipoxygenase	MESH:C063449	240	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Zileuton : the first 5-lipoxygenase inhibitor for the treatment of asthma .
24621065	0	Zinc	0,4	BDNF	68,72	Zinc	BDNF	MESH:D015032	627	Chemical	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Zinc monotherapy increases serum brain-derived_neurotrophic_factor -LRB- BDNF -RRB- levels and decreases_depressive_symptoms in overweight or obese subjects : A double-blind , randomized , placebo-controlled trial .
12761574	0	Zinc	0,4	Bax	14,17	Zinc	Bax	MESH:D015032	581	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|compound|END_ENTITY	Zinc inhibits Bax and Bak activation and cytochrome_c release induced by chemical inducers of apoptosis but not by death-receptor-initiated pathways .
20427734	0	Zinc	0,4	C-reactive_protein	15,33	Zinc	C-reactive protein	MESH:D015032	1401	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|END_ENTITY	Zinc decreases C-reactive_protein , lipid peroxidation , and inflammatory cytokines in elderly subjects : a potential implication of zinc as an atheroprotective agent .
26301820	0	Zinc	13,17	EGR1	34,38	Zinc	EGR1	MESH:D015032	1958	Chemical	Gene	Protein|compound|START_ENTITY Protein|appos|END_ENTITY	Detection of Zinc Finger Protein -LRB- EGR1 -RRB- Based on Electrogenerated Chemiluminescence from Singlet Oxygen Produced in a Nanoclay-Supported Porphyrin Environment .
16481356	0	Zinc	0,4	Fear_of_Intimacy	27,43	Zinc	Fear of Intimacy	MESH:D015032	38976(Tax:7227)	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Zinc transport activity of Fear_of_Intimacy is essential for proper gonad morphogenesis and DE-cadherin expression .
20431123	0	Zinc	0,4	Fezf1	18,23	Zinc	Fezf1	MESH:D015032	73191(Tax:10090)	Chemical	Gene	genes|amod|START_ENTITY genes|dep|END_ENTITY	Zinc finger genes Fezf1 and Fezf2 control neuronal differentiation by repressing Hes5 expression in the forebrain .
22545109	0	Zinc	0,4	GPR39	45,50	Zinc	GPR39	MESH:D015032	2863	Chemical	Gene	signaling|amod|START_ENTITY signaling|acl|mediated mediated|nmod|END_ENTITY	Zinc sensing receptor signaling , mediated by GPR39 , reduces butyrate-induced cell death in HT29 colonocytes via upregulation of clusterin .
25609596	0	Zinc	7,11	GPR39	0,5	Zinc	GPR39	MESH:D015032	71111(Tax:10090)	Chemical	Gene	Receptor|compound|START_ENTITY Mice|appos|Receptor Mice|amod|END_ENTITY	GPR39 -LRB- Zinc Receptor -RRB- Knockout Mice Exhibit Depression-Like Behavior and CREB/BDNF Down-Regulation in the Hippocampus .
21179202	0	Zinc	0,4	HIF-1a	19,25	Zinc	HIF-1a	MESH:D015032	3091	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	Zinc downregulates HIF-1a and inhibits its activity in tumor cells in vitro and in vivo .
11927637	0	Zinc	0,4	Hzf	21,24	Zinc	Hzf	MESH:D015032	29813(Tax:10090)	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Zinc finger protein , Hzf , is required for megakaryocyte development and hemostasis .
25868059	0	Zinc	11,15	Insulin	46,53	Zinc	Insulin	MESH:D015032	3630	Chemical	Gene	Supplementation|compound|START_ENTITY Supplementation|nmod|Markers Markers|nmod|Resistance Resistance|compound|END_ENTITY	Effects of Zinc Supplementation on Markers of Insulin Resistance and Lipid Profiles in Women with Polycystic_Ovary_Syndrome : a Randomized , Double-blind , Placebo-controlled Trial .
25832641	0	Zinc	57,61	MTF-1	105,110	Zinc	MTF-1	MESH:D015032	4520	Chemical	Gene	Response|compound|START_ENTITY Response|nmod|END_ENTITY	Analysis of Cysteine and Histidine Residues Required for Zinc Response of the Transcription Factor Human MTF-1 .
19702872	0	Zinc	0,4	Msn2p	94,99	Zinc	Msn2p	MESH:D015032	855053(Tax:4932)	Chemical	Gene	starvation|compound|START_ENTITY induces|nsubj|starvation induces|dobj|response response|acl:relcl|mediated mediated|nmod|END_ENTITY	Zinc starvation induces a stress response in Saccharomyces_cerevisiae that is mediated by the Msn2p and Msn4p transcriptional activators .
26224629	0	Zinc	18,22	NEMO	13,17	Zinc	NEMO	MESH:D015032	16151(Tax:10090)	Chemical	Gene	Tumor|compound|START_ENTITY Tumor|compound|END_ENTITY	CYLD and the NEMO Zinc Finger Regulate Tumor Necrosis Factor Signaling and Early Embryogenesis .
10225421	0	Zinc	0,4	NF-kappaB	62,71	Zinc	NF-kappaB	MESH:D015032	4790	Chemical	Gene	required|nsubjpass|START_ENTITY required|nmod|inhibition inhibition|nmod|activation activation|amod|END_ENTITY	Zinc is required in pyrrolidine_dithiocarbamate inhibition of NF-kappaB activation .
11574819	0	Zinc	0,4	NF-kappaB	15,24	Zinc	NF-kappaB	MESH:D015032	4790	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Zinc activates NF-kappaB in HUT-78 cells .
12389026	0	Zinc	0,4	NF-kappaB	100,109	Zinc	NF-kappaB	MESH:D015032	4790	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|way way|nmod|activation activation|amod|END_ENTITY	Zinc enhances the expression of interleukin-2 and interleukin-2 receptors in HUT-78 cells by way of NF-kappaB activation .
25549802	0	Zinc	29,33	PARP-1	76,82	Zinc	PARP-1	MESH:D015032	142	Chemical	Gene	Fingers|compound|START_ENTITY Affinities|nmod|Fingers _|nsubj|Affinities _|dobj|Nuclear_Protein Nuclear_Protein|appos|END_ENTITY	Unusual Zn -LRB- II -RRB- Affinities of Zinc Fingers of Poly -LRB- ADP-ribose -RRB- _ Polymerase_1 -LRB- PARP-1 -RRB- Nuclear_Protein .
17349999	0	Zinc	0,4	SLC30A2	20,27	Zinc	SLC30A2	MESH:D015032	7780	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Zinc transporter 2 -LRB- SLC30A2 -RRB- can suppress the vesicular zinc defect of adaptor_protein_3-depleted fibroblasts by promoting zinc accumulation in lysosomes .
24194756	0	Zinc	81,85	SLC30A2	105,112	Zinc	SLC30A2	MESH:D015032	7780	Chemical	Gene	Gene|amod|START_ENTITY Gene|appos|END_ENTITY	Transient Neonatal_Zinc_Deficiency Caused by a Heterozygous G87R Mutation in the Zinc Transporter ZnT-2 -LRB- SLC30A2 -RRB- Gene in the Mother Highlighting the Importance of Zn _ -LRB- 2 + -RRB- for Normal Growth and Development .
26593983	0	Zinc	46,50	SLC30A8	64,71	Zinc	SLC30A8	MESH:D015032	169026	Chemical	Gene	Transporter|compound|START_ENTITY Transporter|appos|END_ENTITY	Genetic , Epigenetic and Biological Effects of Zinc Transporter -LRB- SLC30A8 -RRB- in Type 1 and Type 2 Diabetes .
24619115	0	Zinc	70,74	SLC39A2	62,69	Zinc	SLC39A2	MESH:D015032	29986	Chemical	Gene	Transporter|compound|START_ENTITY Transporter|compound|END_ENTITY	Development of the First Fluorescence Screening Assay for the SLC39A2 Zinc Transporter .
26409456	0	Zinc	0,4	SMAD4	23,28	Zinc	SMAD4	MESH:D015032	4089	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|expression expression|amod|END_ENTITY	Zinc affects miR-548n , SMAD4 , SMAD5 expression in HepG2 hepatocyte and HEp-2 lung cell lines .
26409456	0	Zinc	0,4	SMAD5	30,35	Zinc	SMAD5	MESH:D015032	4090	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|expression expression|amod|END_ENTITY	Zinc affects miR-548n , SMAD4 , SMAD5 expression in HepG2 hepatocyte and HEp-2 lung cell lines .
25793500	0	Zinc	0,4	Sp1	127,130	Zinc	Sp1	MESH:D015032	20683(Tax:10090)	Chemical	Gene	Binding|compound|START_ENTITY Binding|nmod|Recruitment Recruitment|nmod|Nf-y Nf-y|acl|Distinguishing Distinguishing|nmod|END_ENTITY	Zinc Finger Independent Genome-Wide Binding of Sp2 Potentiates Recruitment of Histone-Fold Protein Nf-y Distinguishing It from Sp1 and Sp3 .
8961924	0	Zinc	0,4	TP2	95,98	Zinc	TP2	MESH:D015032	7142	Chemical	Gene	recognition|amod|START_ENTITY recognition|nmod|END_ENTITY	Zinc dependent recognition of a human CpG island sequence by the mammalian spermatidal protein TP2 .
16199054	0	Zinc	0,4	Tim10	38,43	Zinc	Tim10	MESH:D015032	856395(Tax:4932)	Chemical	Gene	binding|compound|START_ENTITY stabilizes|nsubj|binding stabilizes|dobj|END_ENTITY	Zinc binding stabilizes mitochondrial Tim10 in a reduced and import-competent state kinetically .
17963238	0	Zinc	0,4	Tim10	16,21	Zinc	Tim10	MESH:D015032	26519	Chemical	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	Zinc binding of Tim10 : evidence for existence of an unstructured binding intermediate for a zinc finger protein .
24922175	0	Zinc	0,4	ZIP1	29,33	Zinc	ZIP1	MESH:D015032	27173	Chemical	Gene	fortification|amod|START_ENTITY decreases|nsubj|fortification decreases|dobj|expression expression|compound|END_ENTITY	Zinc fortification decreases ZIP1 gene expression of some adolescent females with appropriate plasma zinc levels .
23110240	0	Zinc	0,4	ZIP14	17,22	Zinc	ZIP14	MESH:D015032	213053(Tax:10090)	Chemical	Gene	transporter|nsubj|START_ENTITY transporter|dobj|functions functions|nummod|END_ENTITY	Zinc transporter ZIP14 functions in hepatic zinc , iron and glucose homeostasis during the innate_immune_response -LRB- endotoxemia -RRB- .
26023281	0	Zinc	0,4	ZIP4	64,68	Zinc	ZIP4	MESH:D015032	55630	Chemical	Gene	Supplementation|compound|START_ENTITY Supplementation|nmod|END_ENTITY	Zinc Supplementation in a Randomized Controlled Trial Decreased ZIP4 and ZIP8 mRNA Abundance in Peripheral Blood Mononuclear Cells of Adult Women .
26023281	0	Zinc	0,4	ZIP4	64,68	Zinc	ZIP4	MESH:D015032	55630	Chemical	Gene	Supplementation|compound|START_ENTITY Supplementation|nmod|END_ENTITY	Zinc Supplementation in a Randomized Controlled Trial Decreased ZIP4 and ZIP8 mRNA Abundance in Peripheral Blood Mononuclear Cells of Adult Women .
26599865	0	Zinc	114,118	ZIP4	109,113	Zinc	ZIP4	MESH:D015032	100156896(Tax:9823)	Chemical	Gene	Gene|compound|START_ENTITY Gene|compound|END_ENTITY	The Zinc Concentration in the Diet and the Length of the Feeding Period Affect the Methylation Status of the ZIP4 Zinc Transporter Gene in Piglets .
26599865	0	Zinc	4,8	ZIP4	109,113	Zinc	ZIP4	MESH:D015032	100156896(Tax:9823)	Chemical	Gene	Concentration|compound|START_ENTITY Concentration|dep|Status Status|nmod|Gene Gene|compound|END_ENTITY	The Zinc Concentration in the Diet and the Length of the Feeding Period Affect the Methylation Status of the ZIP4 Zinc Transporter Gene in Piglets .
25986843	0	Zinc	83,87	ZIP9	78,82	Zinc	ZIP9	MESH:D015032	55334	Chemical	Gene	Subfamily|compound|START_ENTITY Subfamily|compound|END_ENTITY	Re : Identification and Characterization of Membrane Androgen Receptors in the ZIP9 Zinc Transporter Subfamily : II .
25986843	0	Zinc	83,87	ZIP9	78,82	Zinc	ZIP9	MESH:D015032	55334	Chemical	Gene	Subfamily|compound|START_ENTITY Subfamily|compound|END_ENTITY	Re : Identification and Characterization of Membrane Androgen Receptors in the ZIP9 Zinc Transporter Subfamily : II .
15017363	0	Zinc	0,4	ZNF202	20,26	Zinc	ZNF202	MESH:D015032	7753	Chemical	Gene	protein|amod|START_ENTITY END_ENTITY|nsubj|protein	Zinc finger protein ZNF202 structure and function in transcriptional control of HDL metabolism .
26463958	0	Zinc	41,45	ZNT-1	0,5	Zinc	ZNT-1	MESH:D015032	7779	Chemical	Gene	Accumulation|compound|START_ENTITY Enhances|xcomp|Accumulation Enhances|nsubj|Reduction Reduction|compound|END_ENTITY	ZNT-1 Expression Reduction Enhances Free Zinc Accumulation in Astrocytes After Ischemic_Stroke .
26272258	0	Zinc	0,4	Zip14	82,87	Zinc	Zip14	MESH:D015032	213053(Tax:10090)	Chemical	Gene	dyshomeostasis|amod|START_ENTITY involves|nsubj|dyshomeostasis involves|dobj|END_ENTITY	Zinc dyshomeostasis during polymicrobial sepsis in mice involves zinc transporter Zip14 and can be overcome by zinc supplementation .
25806541	0	Zinc	14,18	Zip4	0,4	Zinc	Zip4	MESH:D015032	72027(Tax:10090)	Chemical	Gene	Influx|compound|START_ENTITY Influx|compound|END_ENTITY	Zip4 Mediated Zinc Influx Stimulates Insulin Secretion in Pancreatic Beta Cells .
24194756	0	Zinc	81,85	ZnT-2	98,103	Zinc	ZnT-2	MESH:D015032	7780	Chemical	Gene	Gene|amod|START_ENTITY Gene|compound|END_ENTITY	Transient Neonatal_Zinc_Deficiency Caused by a Heterozygous G87R Mutation in the Zinc Transporter ZnT-2 -LRB- SLC30A2 -RRB- Gene in the Mother Highlighting the Importance of Zn _ -LRB- 2 + -RRB- for Normal Growth and Development .
15525635	0	Zinc	0,4	ZnT5	19,23	Zinc	ZnT5	MESH:D015032	427173(Tax:9031)	Chemical	Gene	transporters|amod|START_ENTITY transporters|appos|END_ENTITY	Zinc transporters , ZnT5 and ZnT7 , are required for the activation of alkaline phosphatases , zinc-requiring enzymes that are glycosylphosphatidylinositol-anchored to the cytoplasmic membrane .
18571504	0	Zinc	0,4	aminopeptidase_B	19,35	Zinc	aminopeptidase B	MESH:D015032	6051	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Zinc regulation of aminopeptidase_B involved in neuropeptide production .
6466648	0	Zinc	0,4	androgen_receptor	21,38	Zinc	androgen receptor	MESH:D015032	24208(Tax:10116)	Chemical	Gene	potentiation|amod|START_ENTITY potentiation|nmod|END_ENTITY	Zinc potentiation of androgen_receptor binding to nuclei in vitro .
24621065	0	Zinc	0,4	brain-derived_neurotrophic_factor	33,66	Zinc	brain-derived neurotrophic factor	MESH:D015032	627	Chemical	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	Zinc monotherapy increases serum brain-derived_neurotrophic_factor -LRB- BDNF -RRB- levels and decreases_depressive_symptoms in overweight or obese subjects : A double-blind , randomized , placebo-controlled trial .
9330853	0	Zinc	0,4	catalase	13,21	Zinc	catalase	MESH:D015032	847	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Zinc induces catalase expression in cultured fetal human retinal pigment epithelial cells .
19000913	0	Zinc	0,4	dopamine_transporter	19,39	Zinc	dopamine transporter	MESH:D015032	6531	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Zinc regulates the dopamine_transporter in a membrane potential and chloride dependent manner .
3178229	0	Zinc	0,4	fibrinogen	16,26	Zinc	fibrinogen	MESH:D015032	2244	Chemical	Gene	binding|nsubj|START_ENTITY binding|nmod|END_ENTITY	Zinc binding to fibrinogen and fibrin .
7495802	0	Zinc	0,4	fibroblast_collagenase	35,57	Zinc	fibroblast collagenase	MESH:D015032	4312	Chemical	Gene	content|amod|START_ENTITY content|nmod|END_ENTITY	Zinc content and function in human fibroblast_collagenase .
2270485	0	Zinc	0,4	growth_hormone	39,53	Zinc	growth hormone	MESH:D015032	2688	Chemical	Gene	mediation|amod|START_ENTITY mediation|nmod|the the|nmod|END_ENTITY	Zinc mediation of the binding of human growth_hormone to the human prolactin_receptor .
9548219	0	Zinc	0,4	growth_hormone	53,67	Zinc	growth hormone	MESH:D015032	81668(Tax:10116)	Chemical	Gene	chelation|amod|START_ENTITY enhances|nsubj|chelation enhances|dobj|induction induction|nmod|mRNA mRNA|amod|END_ENTITY	Zinc chelation enhances thyroid hormone induction of growth_hormone mRNA in GH3 cells .
1335969	0	Zinc	0,4	heat_shock_protein	41,59	Zinc	heat shock protein	MESH:D015032	24472(Tax:10116)	Chemical	Gene	toxicity|amod|START_ENTITY toxicity|nmod|END_ENTITY	Zinc toxicity and induction of the 72 kD heat_shock_protein in primary astrocyte culture .
23868099	0	Zinc	0,4	heme_oxygenase-1	45,61	Zinc	heme oxygenase-1	MESH:D015032	3162	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Zinc at sub-cytotoxic concentrations induces heme_oxygenase-1 expression in human cancer cells .
10544234	2	Zinc	292,296	insulin	353,360	Zinc	insulin	MESH:D015032	3630	Chemical	Gene	promoted|nsubj|START_ENTITY promoted|dobj|effects effects|nmod|END_ENTITY	Zinc , but not EtOH , also promoted the stimulatory effects of insulin on activating phosphorylation of p42/p44 mitogen-activated protein -LRB- MAP -RRB- kinases .
16224792	0	Zinc	0,4	insulin	11,18	Zinc	insulin	MESH:D015032	3630	Chemical	Gene	START_ENTITY|nmod|replacement replacement|compound|END_ENTITY	Zinc as an insulin replacement in hybridoma cultures .
26020622	0	Zinc	0,4	insulin	83,90	Zinc	insulin	MESH:D015032	3630	Chemical	Gene	supplementation|amod|START_ENTITY diabetes_mellitus|nsubj|supplementation diabetes_mellitus|nmod|adults adults|nmod|resistance resistance|compound|END_ENTITY	Zinc supplementation for the prevention of type 2 diabetes_mellitus in adults with insulin resistance .
6345344	0	Zinc	0,4	insulin	31,38	Zinc	insulin	MESH:D015032	3630	Chemical	Gene	levels|amod|START_ENTITY levels|nmod|END_ENTITY	Zinc levels in zinc-stabilized insulin are inhibitory to the growth of cells in vitro .
10725786	0	Zinc	0,4	insulin-like_growth_factor-I	50,78	Zinc	insulin-like growth factor-I	MESH:D015032	3479	Chemical	Gene	supplementation|amod|START_ENTITY increases|nsubj|supplementation increases|dobj|level level|nmod|END_ENTITY	Zinc supplementation increases the level of serum insulin-like_growth_factor-I but does not promote growth in infants with nonorganic failure to thrive .
9685221	0	Zinc	0,4	insulin-like_growth_factor-I	19,47	Zinc	insulin-like growth factor-I	MESH:D015032	24482(Tax:10116)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Zinc regulation of insulin-like_growth_factor-I -LRB- IGF-I -RRB- , growth_hormone_receptor _ -LRB- GHR -RRB- _ and_binding_protein -LRB- GHBP -RRB- gene expression in rat cultured hepatocytes .
12427038	0	Zinc	0,4	isopeptidase_T	74,88	Zinc	isopeptidase T	MESH:D015032	8078	Chemical	Gene	required|nsubjpass|START_ENTITY required|nmod|activity activity|nmod|END_ENTITY	Zinc is required for the catalytic activity of the human deubiquitinating isopeptidase_T .
9686591	0	Zinc	0,4	killer_cell-inhibitory_receptor	18,49	Zinc	killer cell-inhibitory receptor	MESH:D015032	3805	Chemical	Gene	START_ENTITY|acl|bound bound|nmod|END_ENTITY	Zinc bound to the killer_cell-inhibitory_receptor modulates the negative signal in human NK cells .
8203889	0	Zinc	0,4	leukotriene_A4_hydrolase	49,73	Zinc	leukotriene A4 hydrolase	MESH:D015032	4048	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|END_ENTITY	Zinc and other divalent cations inhibit purified leukotriene_A4_hydrolase and leukotriene B4 biosynthesis in human polymorphonuclear leukocytes .
14637104	0	Zinc	0,4	metallothionein-iii	19,38	Zinc	metallothionein-iii	MESH:D015032	17751(Tax:10090)	Chemical	Gene	START_ENTITY|acl|released released|nmod|END_ENTITY	Zinc released from metallothionein-iii may contribute to hippocampal CA1 and thalamic neuronal_death following acute_brain_injury .
24157868	0	Zinc	0,4	metallothionein_2A	18,36	Zinc	metallothionein 2A	MESH:D015032	4502	Chemical	Gene	chelation|amod|START_ENTITY chelation|dep|mechanism mechanism|nmod:poss|END_ENTITY	Zinc chelation : a metallothionein_2A 's mechanism of action involved in osteosarcoma cell death and chemotherapy resistance .
26409456	0	Zinc	0,4	miR-548n	13,21	Zinc	miR-548n	MESH:D015032	100302152	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|expression expression|amod|END_ENTITY	Zinc affects miR-548n , SMAD4 , SMAD5 expression in HepG2 hepatocyte and HEp-2 lung cell lines .
10980238	0	Zinc	0,4	neuropeptide_Y	14,28	Zinc	neuropeptide Y	MESH:D015032	24604(Tax:10116)	Chemical	Gene	elevates|nsubj|START_ENTITY elevates|dobj|levels levels|amod|END_ENTITY	Zinc elevates neuropeptide_Y levels in rat pheochromocytoma cells by a mechanism independent of L-channel mediated inhibition of release .
11502552	0	Zinc	0,4	p53	20,23	Zinc	p53	MESH:D015032	7157	Chemical	Gene	status|amod|START_ENTITY affects|nsubj|status affects|dobj|END_ENTITY	Zinc status affects p53 , gadd45 , and c-fos expression and caspase-3 activity in human bronchial epithelial cells .
11554448	0	Zinc	0,4	p53	34,37	Zinc	p53	MESH:D015032	7157	Chemical	Gene	binding|nmod:npmod|START_ENTITY binding|nmod|structure structure|compound|END_ENTITY	Zinc binding and redox control of p53 structure and function .
12095159	0	Zinc	0,4	p53	72,75	Zinc	p53	MESH:D015032	7157	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|translocation translocation|nmod|END_ENTITY	Zinc inhibits the nuclear translocation of the tumor suppressor protein p53 and protects cultured human neurons from copper-induced neurotoxicity .
21932419	0	Zinc	0,4	p53	84,87	Zinc	p53	MESH:D015032	7157	Chemical	Gene	supplementation|amod|START_ENTITY augments|nsubj|supplementation augments|advcl|restoring restoring|dobj|function function|compound|END_ENTITY	Zinc supplementation augments in vivo antitumor effect of chemotherapy by restoring p53 function .
1774132	0	Zinc	0,4	prolactin	91,100	Zinc	prolactin	MESH:D015032	5617	Chemical	Gene	administration|amod|START_ENTITY administration|dep|effects effects|nmod|END_ENTITY	Zinc and bromocriptine long-term administration in patients with prolactinomas : effects on prolactin and thymulin circulating levels .
2753470	0	Zinc	0,4	prolactin	22,31	Zinc	prolactin	MESH:D015032	5617	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|secretion secretion|amod|END_ENTITY	Zinc : an inhibitor of prolactin -LRB- PRL -RRB- secretion in humans .
6646348	0	Zinc	0,4	prolactin	59,68	Zinc	prolactin	MESH:D015032	5617	Chemical	Gene	have|nsubj|START_ENTITY have|dobj|role role|acl|regulating regulating|dobj|secretion secretion|compound|END_ENTITY	Zinc may have a physiological role in regulating pituitary prolactin secretion .
6697238	0	Zinc	0,4	prolactin	60,69	Zinc	prolactin	MESH:D015032	24683(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|compound|END_ENTITY	Zinc acutely , selectively and reversibly inhibits pituitary prolactin secretion .
1888732	0	Zinc	0,4	renin	19,24	Zinc	renin	MESH:D015032	5972	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Zinc inhibition of renin and the protease from human_immunodeficiency_virus_type_1 .
18436240	0	Zinc	0,4	tankyrase_1	39,50	Zinc	tankyrase 1	MESH:D015032	8658	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Zinc binding catalytic domain of human tankyrase_1 .
24970226	0	Zinc_Chaperone	51,65	AMP_Deaminase	86,99	Zinc Chaperone	AMP Deaminase	null	270	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	The Role of Histidine-Proline-Rich_Glycoprotein as Zinc_Chaperone for Skeletal Muscle AMP_Deaminase .
24970226	0	Zinc_Chaperone	51,65	Histidine-Proline-Rich_Glycoprotein	12,47	Zinc Chaperone	Histidine-Proline-Rich Glycoprotein	null	3273	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	The Role of Histidine-Proline-Rich_Glycoprotein as Zinc_Chaperone for Skeletal Muscle AMP_Deaminase .
26910359	0	Zinc_Chloride	0,13	Stat3	89,94	Zinc Chloride	Stat3	MESH:C016837	20848(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|Signaling Signaling|compound|END_ENTITY	Zinc_Chloride Transiently Maintains Mouse Embryonic Stem Cell Pluripotency by Activating Stat3 Signaling .
26716206	0	Zinc_Oxide	0,10	A20	75,78	Zinc Oxide	A20	MESH:D015034	7128	Chemical	Gene	Activation|compound|START_ENTITY Activation|nmod|END_ENTITY	Zinc_Oxide Nanoparticles Suppress LPS-Induced NF-kB Activation by Inducing A20 , a Negative Regulator of NF-kB , in RAW 264.7 Macrophages .
18325350	0	Zinc_mesoporphyrin	0,18	Bach1	84,89	Zinc mesoporphyrin	Bach1	MESH:C058069	571	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|degradation degradation|nmod|END_ENTITY	Zinc_mesoporphyrin induces rapid and marked degradation of the transcription factor Bach1 and up-regulates HO-1 .
22166487	0	Zinc_oxide	0,10	intercellular_adhesion_molecule_1	33,66	Zinc oxide	intercellular adhesion molecule 1	MESH:D015034	3383	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Zinc_oxide nanoparticles-induced intercellular_adhesion_molecule_1 expression requires Rac1/Cdc42 , mixed_lineage_kinase_3 , and c-Jun_N-terminal_kinase activation in endothelial cells .
18620555	0	Zinc_protoporphyrin_IX	0,22	heme_oxygenase-1	26,42	Zinc protoporphyrin IX	heme oxygenase-1	MESH:C017803	15368(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Zinc_protoporphyrin_IX , a heme_oxygenase-1 inhibitor , demonstrates potent antitumor effects but is unable to potentiate antitumor effects of chemotherapeutics in mice .
22027089	0	Zinc_pyrithione	0,15	ERK	24,27	Zinc pyrithione	ERK	MESH:C010423	5594	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Zinc_pyrithione induces ERK - and PKC-dependent necrosis distinct from TPEN-induced apoptosis in prostate_cancer cells .
26436560	0	Zinc_pyrithione	0,15	caspase-3	25,34	Zinc pyrithione	caspase-3	MESH:C010423	836	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Zinc_pyrithione inhibits caspase-3 activity , promotes ErbB1-ErbB2 heterodimerization and suppresses ErbB2 downregulation in cardiomyocytes subjected to ischemia/reperfusion .
23657286	0	Zingerone	0,9	TRPA1	83,88	Zingerone	TRPA1	MESH:C013738	312896(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|advcl|activating activating|dobj|END_ENTITY	Zingerone enhances glutamatergic spontaneous excitatory transmission by activating TRPA1 but not TRPV1 channels in the adult rat substantia gelatinosa .
26698392	0	Zingerone	0,9	Toll-like_receptor_4	83,103	Zingerone	Toll-like receptor 4	MESH:C013738	21898(Tax:10090)	Chemical	Gene	ameliorates|nsubj|START_ENTITY ameliorates|nmod|END_ENTITY	Zingerone ameliorates lipopolysaccharide-induced acute_kidney_injury by inhibiting Toll-like_receptor_4 signaling pathway .
26282055	0	Zingerone	0,9	VMAT2	20,25	Zingerone	VMAT2	MESH:C013738	6571	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Zingerone activates VMAT2 during MPP -LRB- + -RRB- - induced Cell Death .
26282055	0	Zingerone	0,9	VMAT2	20,25	Zingerone	VMAT2	MESH:C013738	6571	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Zingerone activates VMAT2 during MPP -LRB- + -RRB- - induced Cell Death .
10771453	0	Ziprasidone	0,11	cytochrome_P450_2D6	32,51	Ziprasidone	cytochrome P450 2D6	MESH:C092292	1565	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Ziprasidone and the activity of cytochrome_P450_2D6 in healthy extensive metabolizers .
1288050	0	Zixoryn	22,29	cytochrome_P450	38,53	Zixoryn	cytochrome P450	MESH:C016914	25251(Tax:10116)	Chemical	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of flumecinol -LRB- Zixoryn -RRB- on the cytochrome_P450 and cytochrome_P448 dependent hepatic microsomal monooxygenase activities in male rats .
16955409	0	Zn	65,67	ATRX	60,64	Zn	ATRX	null	546	Chemical	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	ATRX_syndrome in a girl with a heterozygous mutation in the ATRX Zn finger domain and a totally skewed X-inactivation pattern .
15670847	0	Zn	44,46	AtHMA4	26,32	Zn	AtHMA4	null	816428(Tax:3702)	Chemical	Gene	transports|dobj|START_ENTITY transports|nsubj|END_ENTITY	The plant P1B-type ATPase AtHMA4 transports Zn and Cd and plays a role in detoxification of transition metals supplied at elevated levels .
9009083	0	Zn	18,20	EVI-1	34,39	Zn	EVI-1	null	2122	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Expression of the Zn finger gene , EVI-1 , in acute_promyelocytic_leukemia .
21548961	0	Zn	9,11	MBNL1	23,28	Zn	MBNL1	null	4154	Chemical	Gene	fingers|compound|START_ENTITY fingers|nmod|END_ENTITY	The four Zn fingers of MBNL1 provide a flexible platform for recognition of its RNA binding elements .
16038907	0	Zn	31,33	MTP1	21,25	Zn	MTP1	null	819293(Tax:3702)	Chemical	Gene	transporter|compound|START_ENTITY transporter|nsubj|END_ENTITY	Arabidopsis_thaliana MTP1 is a Zn transporter in the vacuolar membrane which mediates Zn detoxification and drives leaf Zn accumulation .
24071581	0	Zn	76,78	Nab2	71,75	Zn	Nab2	null	852755(Tax:4932)	Chemical	Gene	fingers|compound|START_ENTITY fingers|amod|END_ENTITY	Structural basis for the molecular recognition of polyadenosine RNA by Nab2 Zn fingers .
10975525	0	Zn	13,15	Senseless	0,9	Zn	Senseless	null	45328(Tax:7227)	Chemical	Gene	factor|compound|START_ENTITY END_ENTITY|appos|factor	Senseless , a Zn finger transcription factor , is necessary and sufficient for sensory organ development in Drosophila .
1427894	0	Zn	19,21	ZNF76	35,40	Zn	ZNF76	null	7629	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A testis-expressed Zn finger gene -LRB- ZNF76 -RRB- in human 6p21 .3 centromeric to the MHC is closely linked to the human homolog of the t-complex gene tcp-11 .
21209194	0	Zn	12,14	Zip-1	28,33	Zn	Zip-1	null	30791(Tax:10090)	Chemical	Gene	transporters|compound|START_ENTITY transporters|amod|END_ENTITY	Knockout of Zn transporters Zip-1 and Zip-3 attenuates seizure-induced CA1 neurodegeneration .
23772702	0	Zn	71,73	aquaporin-4	40,51	Zn	aquaporin-4	null	361	Chemical	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	A general anaesthetic propofol inhibits aquaporin-4 in the presence of Zn .
1871124	0	Zn	56,58	glucocorticoid_receptor	73,96	Zn	glucocorticoid receptor	null	2908	Chemical	Gene	finger|compound|START_ENTITY finger|nmod|END_ENTITY	Repressor to activator switch by mutations in the first Zn finger of the glucocorticoid_receptor : is direct DNA binding necessary ?
8055906	0	Zn	35,37	vitamin_D_receptor	54,72	Zn	vitamin D receptor	null	7421	Chemical	Gene	finger|compound|START_ENTITY finger|nmod|END_ENTITY	A peptide C-terminal to the second Zn finger of human vitamin_D_receptor is able to specify nuclear localization .
12898686	0	ZnII	24,28	CoI	17,20	ZnII	CoI	CHEBI:29105	4512	Chemical	Gene	Stabilization|nmod|START_ENTITY Stabilization|nmod|END_ENTITY	Stabilization of CoI by ZnII in pure acetonitrile and its reaction with aryl_halides .
19123382	0	ZnO	53,56	1-D	41,44	ZnO	1-D	CHEBI:50836	25802	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|nummod|END_ENTITY	-LSB- The preparation and characterization of 1-D orderly ZnO nanorod arrarys -RSB- .
16351296	0	ZnO	48,51	CO2	23,26	ZnO	CO2	CHEBI:50836	717	Chemical	Gene	dynamics|nmod|START_ENTITY dynamics|nmod|END_ENTITY	Adsorption dynamics of CO2 on copper-precovered ZnO -LRB- 0001 -RRB- - Zn : a molecular-beam scattering and thermal-desorption spectroscopy study .
25936037	0	ZnO	67,70	GaN	32,35	ZnO	GaN	CHEBI:50836	8139	Chemical	Gene	based|nmod|START_ENTITY END_ENTITY|acl|based	Light extraction enhancement of GaN based light_emitting_diodes by ZnO nanorod arrays .
19230793	0	ZnO	52,55	tyrosinase	8,18	ZnO	tyrosinase	CHEBI:50836	7299	Chemical	Gene	biosensor|nmod|START_ENTITY biosensor|compound|END_ENTITY	A novel tyrosinase biosensor based on biofunctional ZnO nanorod microarrays on the nanocrystalline diamond electrode for detection of phenolic compounds .
15582353	8	ZnPP	1231,1235	HO-1	1207,1211	ZnPP	HO-1	null	24451(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Upon the inhibition of elevated HO-1 mRNA expression by the use of zinc_protoporphyrin_IX -LRB- ZnPP -RRB- , an inhibitor of HO activity , the change of HO-1 mRNA expression by ZnPP was not observed .
21345685	8	ZnPP	1475,1479	HO-1	1440,1444	ZnPP	SC-1	null	25434(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Finally , treatment with a HO-1 inhibitor , Zn-protoporphyrin -LRB- ZnPP -RRB- , and overexpression of a dominant-negative mutant of Nrf2 diminished SC-1-mediated neuroprotection .
15994300	9	ZnT5	1302,1306	ZnT6	1235,1239	ZnT5	ZnT5	null	427173(Tax:9031)	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	ZnT6-deficient DT40 cells showed low ALP activity , suggesting that ZnT6 is required for the activation of zinc-requiring enzymes like ZnT5 and ZnT7 .
11561030	3	Zn_superoxide	719,732	SOD1	745,749	Zn superoxide	SOD1	null	6647	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	METHOD : Using the statistical technique of motor unit number estimation , a cross sectional study was performed on a group of asymptomatic carriers of the Cu , Zn_superoxide dimutase 1 -LRB- SOD1 -RRB- gene .
15973494	0	Zn_superoxide	39,52	SOD1	64,68	Zn superoxide	SOD1	null	409398(Tax:7460)	Chemical	Gene	cDNA|compound|START_ENTITY cDNA|appos|END_ENTITY	Cloning and characterization of the Cu , Zn_superoxide dismutase -LRB- SOD1 -RRB- cDNA from the mole cricket , Gryllotalpa_orientalis .
16730205	0	Zn_superoxide	18,31	SOD1	43,47	Zn superoxide	SOD1	null	409398(Tax:7460)	Chemical	Gene	dismutase|compound|START_ENTITY dismutase|appos|END_ENTITY	Bombus_ignitus Cu , Zn_superoxide dismutase -LRB- SOD1 -RRB- : cDNA cloning , gene structure , and up-regulation in response to paraquat , temperature stress , or lipopolysaccharide stimulation .
9194892	0	Zn_superoxide	67,80	SOD1	92,96	Zn superoxide	SOD1	null	6647	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	A low expressor line of transgenic_mice carrying a mutant human Cu , Zn_superoxide dismutase -LRB- SOD1 -RRB- gene develops pathological changes that most closely resemble those in human amyotrophic_lateral_sclerosis .
22714120	0	Zn_superoxide	100,113	Sod1p	125,130	Zn superoxide	Sod1p	null	853568(Tax:4932)	Chemical	Gene	START_ENTITY|dobj|activity activity|appos|END_ENTITY	Identification of -LSB- CuCl -LRB- acac -RRB- -LRB- tmed -RRB- -RSB- , a copper -LRB- II -RRB- complex with mixed ligands , as a modulator of Cu , Zn_superoxide dismutase -LRB- Sod1p -RRB- activity in yeast .
2140542	0	Zoladex	104,111	GnRH	115,119	Zoladex	GnRH	MESH:D017273	2796	Chemical	Gene	START_ENTITY|appos|analogue analogue|compound|END_ENTITY	Suppression of plasma androgens by the antiandrogen flutamide in prostatic_cancer patients treated with Zoladex , a GnRH analogue .
2956658	0	Zoladex	26,33	LHRH	12,16	Zoladex	LHRH	MESH:D017273	2796	Chemical	Gene	Value|appos|START_ENTITY Value|nmod|agonist agonist|compound|END_ENTITY	-LSB- Value of a LHRH agonist -LRB- Zoladex -RRB- in hormonotherapy of advanced cancers of the prostate .
2969269	0	Zoladex	24,31	LHRH	10,14	Zoladex	LHRH	MESH:D017273	2796	Chemical	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	Effect of LHRH agonist , Zoladex , on ovarian histology .
3155636	0	Zoladex	76,83	LHRH	50,54	Zoladex	LHRH	MESH:D017273	2796	Chemical	Gene	report|appos|START_ENTITY report|nmod|use use|nmod|formulation formulation|nmod|ICI_118630 ICI_118630|compound|END_ENTITY	Preliminary report on use of depot formulation of LHRH analogue ICI_118630 -LRB- Zoladex -RRB- in patients with prostatic_cancer .
6238116	0	Zoladex	132,139	LHRH	107,111	Zoladex	LHRH	MESH:D017273	2796	Chemical	Gene	ICI_118630|appos|START_ENTITY ICI_118630|compound|END_ENTITY	Treatment of patients with advanced_cancer of the prostate using a slow-release -LRB- depot -RRB- formulation of the LHRH agonist ICI_118630 -LRB- Zoladex -RRB- .
2960958	0	Zoladex	83,90	luteinizing_hormone-releasing_hormone	36,73	Zoladex	luteinizing hormone-releasing hormone	MESH:D017273	25194(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Renewal timing of long-acting depot luteinizing_hormone-releasing_hormone agonist -LRB- Zoladex -RRB- is critical in the treatment of hormone-dependent rat prostatic_carcinoma -LRB- R3327-H -RRB- .
25263354	0	Zoledronate	1,12	TRPV5	22,27	Zoledronate	TRPV5	MESH:C088658	194352(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	-LSB- Zoledronate inhibits TRPV5 and NFATc1 expression during differentiation of osteoclasts -RSB- .
21751240	0	Zoledronic_acid	0,15	SOCS3	36,41	Zoledronic acid	SOCS3	MESH:C088658	9021	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Zoledronic_acid inhibits macrophage SOCS3 expression and enhances cytokine production .
19915386	0	Zoledronic_acid	0,15	six-transmembrane_epithelial_antigen_of_prostate_protein	31,87	Zoledronic acid	six-transmembrane epithelial antigen of prostate protein	MESH:C088658	26872	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|amod|END_ENTITY	Zoledronic_acid decreases mRNA six-transmembrane_epithelial_antigen_of_prostate_protein expression in prostate_cancer cells .
23773293	0	Zoledronic_acid	0,15	vascular_endothelial_growth_factor	45,79	Zoledronic acid	vascular endothelial growth factor	MESH:C088658	7422	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|nmod|END_ENTITY	Zoledronic_acid decreases gene expression of vascular_endothelial_growth_factor and basic_fibroblast_growth_factor by human epithelial cells .
10210888	0	Zolmitriptan	0,12	5-HT1B	16,22	Zolmitriptan	5-HT1B	MESH:C089750	3351	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Zolmitriptan , a 5-HT1B / 1D receptor agonist for the acute oral treatment of migraine : a multicentre , dose-range finding study .
17113947	0	Zolpidem	0,8	Fos	82,85	Zolpidem	Fos	MESH:C049109	314322(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Zolpidem , a selective GABA -LRB- A -RRB- receptor alpha1 subunit agonist , induces comparable Fos expression in oxytocinergic neurons of the hypothalamic paraventricular and accessory but not supraoptic nuclei in the rat .
17659831	0	Zr-MCM-41	40,49	CCl4	32,36	Zr-MCM-41	CCl4	null	6351	Chemical	Gene	decomposition|nmod|START_ENTITY decomposition|nmod|END_ENTITY	Photocatalytic decomposition of CCl4 on Zr-MCM-41 .
12781707	6	Zta	1122,1125	Rta	1099,1102	Zta	Rta	null	23543	Chemical	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	75 -LRB- 2001 -RRB- , 5240 -RRB- , but mutation of this site only had a modest impact on transactivation of Rp by Rta in the presence of Zta .
1822319	0	Zuclopenthixol	0,14	D1/D2	36,41	Zuclopenthixol	D1/D2	MESH:D003006	25802;1646	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Zuclopenthixol , a combined dopamine D1/D2 antagonist , versus haloperidol , a dopamine D2 antagonist , in tardive_dyskinesia .
20209964	0	Zuoguiyin	11,20	VEGF	46,50	Zuoguiyin	VEGF	null	83785(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of Zuoguiyin on expression of ovarian VEGF and SPARC in rats during peri-menopausal period -RSB- .
21958043	0	Zyflamend	0,9	androgen_receptor	36,53	Zyflamend	androgen receptor	MESH:C519312	367	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|nmod|END_ENTITY	Zyflamend reduces the expression of androgen_receptor in a model of castrate-resistant prostate_cancer .
26762192	0	a-Amino_Acids	27,40	Cyclooxygenase_1_and_2	44,66	a-Amino Acids	Cyclooxygenase 1 and 2	null	5742	Chemical	Gene	Derivatives|nmod|START_ENTITY Derivatives|nmod|Inhibitors Inhibitors|compound|END_ENTITY	Isoindoline Derivatives of a-Amino_Acids as Cyclooxygenase_1_and_2 Inhibitors .
23500883	0	a-Cyperone	0,10	COX-2	81,86	a-Cyperone	COX-2	null	17709(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	a-Cyperone , isolated from the rhizomes of Cyperus rotundus , inhibits LPS-induced COX-2 expression and PGE2 production through the negative regulation of NFkB signalling in RAW 264.7 cells .
25849384	0	a-Fe2O3	58,65	CO2	24,27	a-Fe2O3	CO2	null	717	Chemical	Gene	Activity|nmod|START_ENTITY Activity|compound|END_ENTITY	Enhanced Photoreduction CO2 Activity over Direct Z-Scheme a-Fe2O3 / Cu2O Heterostructures under Visible Light Irradiation .
25849384	0	a-Fe2O3	58,65	CO2	24,27	a-Fe2O3	CO2	null	717	Chemical	Gene	Activity|nmod|START_ENTITY Activity|compound|END_ENTITY	Enhanced Photoreduction CO2 Activity over Direct Z-Scheme a-Fe2O3 / Cu2O Heterostructures under Visible Light Irradiation .
24469983	0	a-HPMS	155,161	glycolate_oxidase	168,185	a-HPMS	glycolate oxidase	null	51179	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	The effect of O2 and CO_2 concentration on photosynthesis and glycolate accumulation in bean leaves treated with a-hydroxy-2-pyridinemethanesulfonic_acid -LRB- a-HPMS -RRB- , the glycolate_oxidase inhibitor .
26865286	0	a-Hederin	10,19	IL-2	23,27	a-Hederin	IL-2	null	116562(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|mRNA mRNA|amod|END_ENTITY	Effect of a-Hederin on IL-2 and IL-17 mRNA and miRNA-133a Levels in Lungs of Ovalbumin-Sensitized Male Rats .
24173418	0	a-Isopropylmalate	186,203	LEU1	139,143	a-Isopropylmalate	LEU1	null	852875(Tax:4932)	Chemical	Gene	controlled|nmod|START_ENTITY controlled|nsubjpass|expression expression|compound|END_ENTITY	Leucine biosynthesis in yeast : Identification of two genes -LRB- LEU4 , LEU5 -RRB- that affect a-Isopropylmalate synthase activity and evidence that LEU1 and LEU2 gene expression is controlled by a-Isopropylmalate and the product of a regulatory gene .
25971966	0	a-Lipoic_Acid	15,28	hSMVT	74,79	a-Lipoic Acid	hSMVT	null	8884	Chemical	Gene	Transporter|amod|START_ENTITY Transporter|appos|END_ENTITY	Interaction of a-Lipoic_Acid with the Human Na + / Multivitamin Transporter -LRB- hSMVT -RRB- .
24975507	0	a-Lipoic_acid	0,13	interferon_regulatory_factor_1	62,92	a-Lipoic acid	interferon regulatory factor 1	null	3659	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	a-Lipoic_acid -LRB- a-LA -RRB- inhibits the transcriptional activity of interferon_regulatory_factor_1 -LRB- IRF-1 -RRB- via SUMOylation .
26655383	0	a-Lipoic_acid	0,13	peroxisome_proliferator-activated_receptor	41,83	a-Lipoic acid	peroxisome proliferator-activated receptor	null	19013(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	a-Lipoic_acid up-regulates expression of peroxisome_proliferator-activated_receptor b in skeletal muscle : involvement of the JNK signaling pathway .
26688571	0	a-Solanine	0,10	vascular_endothelial_growth_factor	20,54	a-Solanine	vascular endothelial growth factor	null	7422	Chemical	Gene	inhibits|advmod|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	a-Solanine inhibits vascular_endothelial_growth_factor expression by down-regulating the ERK1/2-HIF -1 a and STAT3 signaling pathways .
25764210	0	a-Spinasterol	0,13	TRPV1	17,22	a-Spinasterol	TRPV1	null	193034(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	a-Spinasterol , a TRPV1 receptor antagonist , elevates the seizure threshold in three acute seizure tests in mice .
23287638	0	a-Tocopherol	0,12	HDL3	54,58	a-Tocopherol	HDL3	null	53369	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	a-Tocopherol induces proatherogenic changes to HDL2 _ HDL3 : an in vitro and ex vivo investigation .
26749581	0	a-Tocopheryl_Phosphate	65,87	Glutathione_Reductase	20,41	a-Tocopheryl Phosphate	Glutathione Reductase	null	14782(Tax:10090)	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|END_ENTITY	Modulation of Brain Glutathione_Reductase and Peroxiredoxin_2 by a-Tocopheryl_Phosphate .
24524041	0	a-Tocopheryl_Succinate	0,22	RANKL	120,125	a-Tocopheryl Succinate	RANKL	null	21943(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|Expression Expression|appos|END_ENTITY	a-Tocopheryl_Succinate Inhibits Osteoclast Formation by Suppressing Receptor_Activator_of_Nuclear_Factor-kappaB_Ligand -LRB- RANKL -RRB- Expression and Bone Resorption .
24524041	0	a-Tocopheryl_Succinate	0,22	Receptor_Activator_of_Nuclear_Factor-kappaB_Ligand	68,118	a-Tocopheryl Succinate	Receptor Activator of Nuclear Factor-kappaB Ligand	null	21943(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|Expression Expression|compound|END_ENTITY	a-Tocopheryl_Succinate Inhibits Osteoclast Formation by Suppressing Receptor_Activator_of_Nuclear_Factor-kappaB_Ligand -LRB- RANKL -RRB- Expression and Bone Resorption .
22307086	0	a-adducin	11,20	ADD-1	22,27	a-adducin	ADD-1	null	180760(Tax:6239)	Chemical	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A role for a-adducin -LRB- ADD-1 -RRB- in nematode and human memory .
24452473	0	a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic_acid	20,72	GluA1	14,19	a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid	GluA1	null	2890	Chemical	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Regulation of GluA1 a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic_acid receptor function by protein kinase C at serine-818 and threonine-840 .
23184625	0	a-amino_acids	30,43	CO2	90,93	a-amino acids	CO2	null	717	Chemical	Gene	synthesis|nmod|START_ENTITY END_ENTITY|nsubj|synthesis	One-step synthesis of racemic a-amino_acids from aldehydes , amine components , and gaseous CO2 by the aid of a bismetal reagent .
25064825	0	a-crystallin	11,23	caspase-3	47,56	a-crystallin	caspase-3	null	25402(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Endogenous a-crystallin inhibits expression of caspase-3 induced by hypoxia in retinal neurons .
24875600	0	a-difluoromethylornithine	121,146	ornithine_decarboxylase	177,200	a-difluoromethylornithine	ornithine decarboxylase	null	24609(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Role of ornithine_decarboxylase and the polyamines in nervous system development : Short-term postnatal administration of a-difluoromethylornithine , an irreversible inhibitor of ornithine_decarboxylase .
24913977	0	a-galactosylceramide	21,41	CD8a	45,49	a-galactosylceramide	CD8a	null	12525(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|+ +|amod|END_ENTITY	Targeted delivery of a-galactosylceramide to CD8a + dendritic cells optimizes type I NKT cell-based antitumor responses .
21245306	3	a-gustducin	529,540	ghrelin	509,516	a-gustducin	ghrelin	null	58991(Tax:10090)	Chemical	Gene	release|nmod|START_ENTITY release|compound|END_ENTITY	This study aimed to investigate whether T2R-agonists affect -LRB- i -RRB- ghrelin release via a-gustducin and -LRB- ii -RRB- food intake and gastric emptying via the release of ghrelin .
26912497	0	a-linolenic_acid	15,31	insulin	61,68	a-linolenic acid	insulin	null	3630	Chemical	Gene	associated|nsubjpass|START_ENTITY associated|nmod|resistance resistance|compound|END_ENTITY	Adipose tissue a-linolenic_acid is inversely associated with insulin resistance in adults .
21991326	0	a-linolenic_acids	62,79	BCR-ABL	83,90	a-linolenic acids	BCR-ABL	null	25	Chemical	Gene	START_ENTITY|nmod|cells cells|amod|END_ENTITY	Leptin reverts pro-apoptotic and antiproliferative effects of a-linolenic_acids in BCR-ABL positive leukemic cells : involvement of PI3K pathway .
21507637	0	a-sulfone_hydroxamates	17,39	MMP-13	0,6	a-sulfone hydroxamates	MMP-13	null	171052(Tax:10116)	Chemical	Gene	START_ENTITY|amod|selective selective|amod|END_ENTITY	MMP-13 selective a-sulfone_hydroxamates : a survey of P1 ' heterocyclic_amide isosteres .
23160821	0	a-tocopherol	30,42	Cytochrome_P450	0,15	a-tocopherol	Cytochrome P450	null	13079(Tax:10090)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Cytochrome_P450 regulation by a-tocopherol in Pxr-null and PXR-humanized mice .
24721530	7	a-tocopherol	1215,1227	Nrf2	1246,1250	a-tocopherol	Nrf2	null	4780	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	It was hypothesized that a-tocopherol via activation of Nrf2 affects expression and turnover of hypocretin , leading to an increased amount of hypocretina-specific fragments that bind to DQB1 * 602 .
23816813	0	a-tocopherol	30,42	TNF-a	99,104	a-tocopherol	TNF-a	null	21926(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY induced|nsubj|effect induced|nmod|END_ENTITY	Antidepressant-like effect of a-tocopherol in a mouse model of depressive-like behavior induced by TNF-a .
21517103	0	a-tocopheryl_succinate	64,86	Hsp90	91,96	a-tocopheryl succinate	Hsp90	null	3320	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|amod|END_ENTITY	Nano self-assembly of recombinant human gelatin conjugated with a-tocopheryl_succinate for Hsp90 inhibitor , 17-AAG , delivery .
19291609	10	aPPD	1376,1380	P-gp	1451,1455	aPPD	P-gp	null	67078(Tax:10090)	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	The above results indicate that aPPD , unlike its precursor ginsenosides_Rg3 and Rh2 , is not a substrate of P-gp .
18256392	0	abacavir	45,53	HLA-B	0,5	abacavir	HLA-B	MESH:C106538	3106	Chemical	Gene	*|nmod|START_ENTITY *|nsubj|END_ENTITY	HLA-B * 5701 screening for hypersensitivity to abacavir .
24141629	0	abexinostat	34,45	Xist	114,118	abexinostat	Xist	null	7503	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|expression expression|compound|END_ENTITY	The histone deacetylase inhibitor abexinostat induces cancer stem cells differentiation in breast_cancer with low Xist expression .
19223900	0	abiraterone	18,29	CYP17	0,5	abiraterone	CYP17	MESH:C089740	1586	Chemical	Gene	blockade|nmod|START_ENTITY blockade|nummod|END_ENTITY	CYP17 blockade by abiraterone : further evidence for frequent continued hormone-dependence in castration-resistant_prostate_cancer .
24276076	0	abiraterone	18,29	CYP17	0,5	abiraterone	CYP17	MESH:C089740	1586	Chemical	Gene	inhibitors|dep|START_ENTITY inhibitors|nummod|END_ENTITY	CYP17 inhibitors -- abiraterone , C17,20-lyase inhibitors and multi-targeting agents .
21807635	0	abiraterone	38,49	CYP17A1	14,21	abiraterone	CYP17A1	MESH:C089740	1586	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nummod|END_ENTITY	Resistance to CYP17A1 inhibition with abiraterone in castration-resistant_prostate_cancer : induction of steroidogenesis and androgen_receptor splice variants .
22170708	0	abiraterone	65,76	CYP17A1	41,48	abiraterone	CYP17A1	MESH:C089740	1586	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nummod|END_ENTITY	Clinical and biochemical consequences of CYP17A1 inhibition with abiraterone given with and without exogenous glucocorticoids in castrate men with advanced prostate_cancer .
24508512	0	abiraterone	102,113	CYP17A1	80,87	abiraterone	CYP17A1	MESH:C089740	1586	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|azoles azoles|acl|retaining retaining|dobj|END_ENTITY	A-ring modified steroidal azoles retaining similar potent and slowly reversible CYP17A1 inhibition as abiraterone .
26954071	0	abiraterone	105,116	CYP17A1	0,7	abiraterone	CYP17A1	MESH:C089740	1586	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|polymorphisms polymorphisms|nummod|END_ENTITY	CYP17A1 polymorphisms and clinical outcome of castration-resistant_prostate_cancer patients treated with abiraterone .
22266943	0	abiraterone	62,73	cytochrome_P450_17A1	14,34	abiraterone	cytochrome P450 17A1	MESH:C089740	1586	Chemical	Gene	Structures|amod|START_ENTITY Structures|nmod|END_ENTITY	Structures of cytochrome_P450_17A1 with prostate_cancer drugs abiraterone and TOK-001 .
20159824	0	abiraterone_acetate	46,65	CYP17	30,35	abiraterone acetate	CYP17	MESH:C089742	1586	Chemical	Gene	START_ENTITY|csubj|Phase Phase|xcomp|trial trial|nmod|inhibitor inhibitor|compound|END_ENTITY	Phase I clinical trial of the CYP17 inhibitor abiraterone_acetate demonstrating clinical activity in patients with castration-resistant_prostate_cancer who received prior ketoconazole therapy .
10872217	0	abscisic_acid	40,53	ABI1	10,14	abscisic acid	ABI1	MESH:D000040	828714(Tax:3702)	Chemical	Gene	expression|amod|START_ENTITY involved|nmod|expression involved|nsubjpass|END_ENTITY	The genes ABI1 and ABI2 are involved in abscisic_acid - and drought-inducible expression of the Daucus_carota_L .
8898906	0	abscisic_acid	32,45	ABI1	61,65	abscisic acid	ABI1	MESH:D000040	828714(Tax:3702)	Chemical	Gene	protein|amod|START_ENTITY protein|compound|END_ENTITY	Protein phosphatase activity of abscisic_acid insensitive 1 -LRB- ABI1 -RRB- protein from Arabidopsis_thaliana .
12368505	0	abscisic_acid	38,51	ABI4	6,10	abscisic acid	ABI4	MESH:D000040	818614(Tax:3702)	Chemical	Gene	genes|compound|START_ENTITY element1|nmod|genes binds|dobj|element1 binds|nsubj|END_ENTITY	Maize ABI4 binds coupling element1 in abscisic_acid and sugar response genes .
18363631	0	abscisic_acid	38,51	ABI4	97,101	abscisic acid	ABI4	MESH:D000040	818614(Tax:3702)	Chemical	Gene	abrogates|nmod|START_ENTITY abrogates|advcl|competing competing|nmod|END_ENTITY	Tomato ASR1 abrogates the response to abscisic_acid and glucose in Arabidopsis by competing with ABI4 for DNA binding .
21097710	0	abscisic_acid	14,27	ABI4	0,4	abscisic acid	ABI4	MESH:D000040	818614(Tax:3702)	Chemical	Gene	inhibition|amod|START_ENTITY mediates|dobj|inhibition mediates|nsubj|END_ENTITY	ABI4 mediates abscisic_acid and cytokinin inhibition of lateral root formation by reducing polar auxin transport in Arabidopsis .
23818868	0	abscisic_acid	69,82	ABI4	0,4	abscisic acid	ABI4	MESH:D000040	818614(Tax:3702)	Chemical	Gene	biogenesis|nmod|START_ENTITY regulating|dobj|biogenesis regulates|advcl|regulating regulates|nsubj|END_ENTITY	ABI4 regulates primary seed dormancy by regulating the biogenesis of abscisic_acid and gibberellins in arabidopsis .
26163700	0	abscisic_acid	59,72	ABI4	147,151	abscisic acid	ABI4	MESH:D000040	818614(Tax:3702)	Chemical	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	An Arabidopsis mitochondria-localized RRL protein mediates abscisic_acid signal transduction through mitochondrial retrograde regulation involving ABI4 .
10972884	0	abscisic_acid	101,114	ABSCISIC_ACID_INSENSITIVE-4	57,84	abscisic acid	ABSCISIC ACID INSENSITIVE-4	MESH:D000040	818614(Tax:3702)	Chemical	Gene	involvement|nmod|START_ENTITY END_ENTITY|dep|involvement	The Arabidopsis SUCROSE UNCOUPLED-6 gene is identical to ABSCISIC_ACID_INSENSITIVE-4 : involvement of abscisic_acid in sugar responses .
20133881	0	abscisic_acid	40,53	AtABCG25	16,24	abscisic acid	AtABCG25	MESH:D000040	843527(Tax:3702)	Chemical	Gene	transport|amod|START_ENTITY involved|nmod|transport involved|nsubjpass|END_ENTITY	ABC transporter AtABCG25 is involved in abscisic_acid transport and responses .
26743432	0	abscisic_acid	10,23	AtLOS5	66,72	abscisic acid	AtLOS5	MESH:D000040	838224(Tax:3702)	Chemical	Gene	levels|amod|START_ENTITY levels|nmod|END_ENTITY	Increased abscisic_acid levels in transgenic maize overexpressing AtLOS5 mediated root ion fluxes and leaf water status under salt stress .
19484493	0	abscisic_acid	34,47	AtMKK1	0,6	abscisic acid	AtMKK1	MESH:D000040	828713(Tax:3702)	Chemical	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	AtMKK1 and AtMPK6 are involved in abscisic_acid and sugar signaling in Arabidopsis seed germination .
21979081	0	abscisic_acid	26,39	CATALASE2	13,22	abscisic acid	CATALASE2	MESH:D000040	829661(Tax:3702)	Chemical	Gene	START_ENTITY|nsubj|roles roles|nmod|END_ENTITY	The roles of CATALASE2 in abscisic_acid signaling in Arabidopsis guard cells .
11485991	0	abscisic_acid	83,96	FIERY1	0,6	abscisic acid	FIERY1	MESH:D000040	836519(Tax:3702)	Chemical	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	FIERY1 encoding an inositol_polyphosphate 1-phosphatase is a negative regulator of abscisic_acid and stress signaling in Arabidopsis .
19969520	0	abscisic_acid	61,74	Farnesylcysteine_lyase	0,22	abscisic acid	Farnesylcysteine lyase	MESH:D000040	836512(Tax:3702)	Chemical	Gene	regulation|nmod|START_ENTITY involved|nmod|regulation involved|nsubjpass|END_ENTITY	Farnesylcysteine_lyase is involved in negative regulation of abscisic_acid signaling in Arabidopsis .
15300440	0	abscisic_acid	27,40	JERF1	90,95	abscisic acid	JERF1	MESH:D000040	544182(Tax:4081)	Chemical	Gene	expression|amod|START_ENTITY expression|nummod|END_ENTITY	The ethylene - , jasmonate - , abscisic_acid - and NaCl-responsive tomato transcription factor JERF1 modulates expression of GCC box-containing genes and salt tolerance in tobacco .
20699393	0	abscisic_acid	55,68	NPC4	28,32	abscisic acid	NPC4	MESH:D000040	821243(Tax:3702)	Chemical	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Nonspecific phospholipase_C NPC4 promotes responses to abscisic_acid and tolerance to hyperosmotic stress in Arabidopsis .
10938377	8	abscisic_acid	1064,1077	PEPC	1104,1108	abscisic acid	PEPC	MESH:D000040	5105	Chemical	Gene	induced|nsubj|START_ENTITY induced|dobj|expression expression|nmod|END_ENTITY	Finally , abscisic_acid induced the expression of PEPC and NADP-ME in a manner similar to temperature induction , except that the activities of both PEPC isoforms were increased .
16099207	0	abscisic_acid	63,76	Phospholipase_D	0,15	abscisic acid	Phospholipase D	MESH:D000040	2822	Chemical	Gene	species|amod|START_ENTITY END_ENTITY|nmod|species	Phospholipase_D in the signaling networks of plant response to abscisic_acid and reactive oxygen species .
21098678	0	abscisic_acid	78,91	RACK1	27,32	abscisic acid	RACK1	MESH:D000040	10399	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of Arabidopsis RACK1 in protein translation and its regulation by abscisic_acid .
19286935	0	abscisic_acid	77,90	RHA2a	38,43	abscisic acid	RHA2a	MESH:D000040	838073(Tax:3702)	Chemical	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	The Arabidopsis RING finger E3 ligase RHA2a is a novel positive regulator of abscisic_acid signaling during seed germination and early seedling development .
21478367	0	abscisic_acid	85,98	RHA2a	65,70	abscisic acid	RHA2a	MESH:D000040	838073(Tax:3702)	Chemical	Gene	signaling|amod|START_ENTITY regulating|dobj|signaling END_ENTITY|acl|regulating	The Arabidopsis RING finger E3 ligase RHA2b acts additively with RHA2a in regulating abscisic_acid signaling and drought response .
21478367	1	abscisic_acid	245,258	RHA2a	218,223	abscisic acid	RHA2b	MESH:D000040	814644(Tax:3702)	Chemical	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	We have previously shown that the Arabidopsis -LRB- Arabidopsis_thaliana -RRB- RING-H2 E3 ligase RHA2a positively regulates abscisic_acid -LRB- ABA -RRB- signaling during seed germination and postgerminative growth .
20348211	0	abscisic_acid	15,28	VvHT5	101,106	abscisic acid	VvHT5	MESH:D000040	100232950(Tax:29760)	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Involvement of abscisic_acid in the coordinated regulation of a stress-inducible hexose transporter -LRB- VvHT5 -RRB- and a cell wall invertase in grapevine in response to biotrophic fungal_infection .
24408191	0	abscisic_acid	26,39	lupin	56,61	abscisic acid	lupin	MESH:D000040	51251	Chemical	Gene	levels|amod|START_ENTITY levels|nmod|END_ENTITY	Effect of water stress on abscisic_acid levels in white lupin -LRB- Lupinus albus L. -RRB- fruit , leaves and phloem exudate .
2528055	0	abscisic_acid	44,57	peroxidase	112,122	abscisic acid	peroxidase	MESH:D000040	102577694	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Molecular cloning , nucleotide sequence , and abscisic_acid induction of a suberization-associated highly anionic peroxidase .
14967696	0	abscisic_acid	47,60	sap	84,87	abscisic acid	sap	MESH:D000040	4068	Chemical	Gene	content|amod|START_ENTITY content|nmod|END_ENTITY	Effects of soil freezing and drought stress on abscisic_acid content of sugar maple sap and leaves .
24519895	0	acadesine	35,44	AICAR	46,51	acadesine	AICAR	MESH:C011651	471	Chemical	Gene	activity|nmod|START_ENTITY activity|appos|END_ENTITY	Synergistic anti-tumor activity of acadesine -LRB- AICAR -RRB- in combination with the anti-CD20 monoclonal antibody rituximab in in vivo and in vitro models of mantle_cell_lymphoma .
8982717	0	acamprosate	22,33	c-fos	42,47	acamprosate	c-fos	MESH:C043877	314322(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|amod|END_ENTITY	The anti-craving drug acamprosate reduces c-fos expression in rats undergoing ethanol withdrawal .
9792335	0	acanthoic_acid	11,25	TNF-alpha	29,38	acanthoic acid	TNF-alpha	MESH:C099958	7124	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|amod|END_ENTITY	Effects of acanthoic_acid on TNF-alpha gene expression and haptoglobin synthesis .
9742458	0	acarbose	10,18	alpha-glucosidase	20,37	acarbose	alpha-glucosidase	MESH:D020909	69983(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|inhibitor inhibitor|amod|END_ENTITY	Effect of acarbose -LRB- alpha-glucosidase inhibitor -RRB- on disaccharase activity in small intestine in KK-Ay and ddY mice .
23642288	0	acarbose	34,42	glucagon-like_peptide_1	46,69	acarbose	glucagon-like peptide 1	MESH:D020909	2641	Chemical	Gene	START_ENTITY|nmod|patients patients|amod|END_ENTITY	Effects of 24-week treatment with acarbose on glucagon-like_peptide_1 in newly diagnosed type 2 diabetic patients : a preliminary report .
10824717	0	acarbose	13,21	insulin	39,46	acarbose	insulin	MESH:D020909	3630	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|requirements requirements|compound|END_ENTITY	Influence of acarbose on post-prandial insulin requirements in patients with Type 1 diabetes .
12542723	0	acarbose	28,36	insulin	57,64	acarbose	insulin	MESH:D020909	3630	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|sensitivity sensitivity|compound|END_ENTITY	Influence of treatment with acarbose or glibenclamide on insulin sensitivity in type 2 diabetic patients .
14686965	0	acarbose	14,22	insulin	26,33	acarbose	insulin	MESH:D020909	3630	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	The effect of acarbose on insulin resistance in obese hypertensive subjects with normal glucose tolerance : a randomized controlled study .
15216448	0	acarbose	16,24	insulin	28,35	acarbose	insulin	MESH:D020909	3630	Chemical	Gene	START_ENTITY|nmod|lispro lispro|compound|END_ENTITY	The addition of acarbose to insulin lispro reduces acute glycaemic responses in patients with type-2 diabetes .
20385430	0	acarbose	15,23	insulin	104,111	acarbose	insulin	MESH:D020909	3630	Chemical	Gene	Combination|nmod|START_ENTITY prevents|nsubj|Combination prevents|dobj|break break|nmod|resistance resistance|compound|END_ENTITY	Combination of acarbose and ezetimibe prevents non-alcoholic_fatty_liver_disease : a break of intestinal insulin resistance ?
23530576	0	acarbose	134,142	insulin	106,113	acarbose	insulin	MESH:D020909	3630	Chemical	Gene	comparing|nmod|START_ENTITY comparing|dobj|efficacy efficacy|nmod|END_ENTITY	A prospective , randomized , open-label study comparing the efficacy and safety of preprandial and prandial insulin in combination with acarbose in elderly , insulin-requiring patients with type_2_diabetes_mellitus .
8432223	0	acarbose	9,17	insulin	81,88	acarbose	insulin	MESH:D020909	3630	Chemical	Gene	improves|nsubj|START_ENTITY improves|nmod|changes changes|nmod|sensitivity sensitivity|compound|END_ENTITY	Low-dose acarbose improves glycemic control in NIDDM patients without changes in insulin sensitivity .
8689858	0	acarbose	14,22	insulin	26,33	acarbose	insulin	MESH:D020909	3630	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|sensitivity sensitivity|compound|END_ENTITY	The effect of acarbose on insulin sensitivity in subjects with impaired_glucose_tolerance .
11850098	0	acarbose	21,29	proinsulin	51,61	acarbose	proinsulin	MESH:D020909	3630	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|profiles profiles|compound|END_ENTITY	Different effects of acarbose and glibenclamide on proinsulin and insulin profiles in people with Type 2 diabetes .
19689250	0	acarbose	11,19	proinsulin	23,33	acarbose	proinsulin	MESH:D020909	3630	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of acarbose on proinsulin and insulin secretion and their potential significance for the intermediary metabolism and cardiovascular system .
8576544	0	acebutolol	30,40	a_beta	42,48	acebutolol	a beta	MESH:D000070	11820(Tax:10090)	Chemical	Gene	START_ENTITY|appos|blocker blocker|compound|END_ENTITY	Evidence for a dual effect of acebutolol , a_beta blocker , on the mouse humoral immune response .
15116049	0	acenocoumarol	45,58	CYP2C9	0,6	acenocoumarol	CYP2C9	MESH:D000074	1559	Chemical	Gene	therapy|nmod|START_ENTITY therapy|compound|END_ENTITY	CYP2C9 and oral anticoagulation therapy with acenocoumarol and warfarin : similarities yet differences .
23159639	0	acenocoumarol	53,66	CYP2C9	18,24	acenocoumarol	CYP2C9	MESH:D000074	1559	Chemical	Gene	requirements|amod|START_ENTITY polymorphisms|nmod|requirements polymorphisms|nsubj|impact impact|nmod|END_ENTITY	The impact of the CYP2C9 and VKORC1 polymorphisms on acenocoumarol dose requirements in a Romanian population .
2284053	0	acephate	77,85	Acetylcholinesterase	0,20	acephate	Acetylcholinesterase	MESH:C001969	43	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|END_ENTITY	Acetylcholinesterase and neuropathy_target_esterase in chickens treated with acephate .
11048668	0	acephate	17,25	acetylcholinesterase	47,67	acephate	acetylcholinesterase	MESH:C001969	83817(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activity activity|amod|END_ENTITY	Acute effects of acephate and methamidophos on acetylcholinesterase activity , endocrine system and amino_acid concentrations in rats .
3798464	0	acephate	71,79	acetylcholinesterase	20,40	acephate	acetylcholinesterase	MESH:C001969	83817(Tax:10116)	Chemical	Gene	combinations|nmod|START_ENTITY inhibition|nmod|combinations inhibition|nsubj|analysis analysis|nmod|END_ENTITY	Kinetic analysis of acetylcholinesterase inhibition by combinations of acephate and methamidophos .
4060156	0	acephate	109,117	acetylcholinesterase	59,79	acephate	acetylcholinesterase	MESH:C001969	43	Chemical	Gene	cholinesterase|nmod|START_ENTITY cholinesterase|nsubj|analysis analysis|nmod|inhibition inhibition|nmod|cell cell|amod|END_ENTITY	Kinetic analysis of inhibition of brain and red blood cell acetylcholinesterase and plasma cholinesterase by acephate or methamidophos .
1530553	0	acepromazine	10,22	factor_VIII	52,63	acepromazine	factor VIII	MESH:D000075	403875(Tax:9615)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	Effect of acepromazine , xylazine and thiopentone on factor_VIII activity and von_Willebrand factor antigen concentration in dogs .
2606317	0	acetabulum	57,67	hip	53,56	acetabulum	hip	null	5068	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- The computer-assisted spatial reconstruction of the hip acetabulum -RSB- .
20016718	0	acetaldehyde	75,87	10-formyltetrahydrofolate_dehydrogenase	23,62	acetaldehyde	10-formyltetrahydrofolate dehydrogenase	MESH:D000079	64392(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	In vitro inhibition of 10-formyltetrahydrofolate_dehydrogenase activity by acetaldehyde .
7887984	1	acetaldehyde	234,246	ALDH	201,205	acetaldehyde	ALDH	MESH:D000079	25375(Tax:10116)	Chemical	Gene	accumulation|nmod|START_ENTITY causing|dobj|accumulation inhibits|dep|causing inhibits|nsubj|aldehyde_dehydrogenase aldehyde_dehydrogenase|appos|END_ENTITY	Disulfiram inhibits hepatic aldehyde_dehydrogenase -LRB- ALDH -RRB- causing an accumulation of acetaldehyde after ethanol ingestion .
7993664	0	acetaldehyde	39,51	Ahd-2	72,77	acetaldehyde	Ahd-2	MESH:D000079	11668(Tax:10090)	Chemical	Gene	gene|amod|START_ENTITY analysis|nmod|gene analysis|appos|END_ENTITY	DNA sequence analysis of the cytosolic acetaldehyde dehydrogenase gene -LRB- Ahd-2 -RRB- in mouse strains with variable ethanol preferences .
17127431	1	acetaldehyde	133,145	Aldh	159,163	acetaldehyde	Aldh	MESH:D000079	11670(Tax:10090)	Chemical	Gene	mice|amod|START_ENTITY mice|appos|END_ENTITY	In this study , we evaluated the inhalation toxicity of acetaldehyde in Aldh2 KO -LRB- Aldh - / - -RRB- mice , using pathological method .
21687683	0	acetaldehyde	72,84	C/EBPa	94,100	acetaldehyde	C/EBPa	MESH:D000079	1050	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Down regulation of a matrix degrading cysteine protease cathepsin_L , by acetaldehyde : role of C/EBPa .
11410717	0	acetaldehyde	36,48	aldh2	116,121	acetaldehyde	aldh2	MESH:D000079	217	Chemical	Gene	START_ENTITY|dep|not not|nmod|END_ENTITY	4-Methylpyrazole decreases salivary acetaldehyde levels in aldh2-deficient subjects but not in subjects with normal aldh2 .
7625566	0	acetaldehyde	175,187	beta-endorphin	214,228	acetaldehyde	beta-endorphin	MESH:D000079	5443	Chemical	Gene	START_ENTITY|nmod|stimulation stimulation|nmod|release release|amod|END_ENTITY	Effect of ethanol , propanol , butanol , and catalase enzyme blockers on beta-endorphin secretion from primary cultures of hypothalamic neurons : evidence for a mediatory role of acetaldehyde in ethanol stimulation of beta-endorphin release .
17932768	0	acetaldehyde	10,22	cathepsin_G_and_chymase	28,51	acetaldehyde	cathepsin G and chymase	MESH:D000079	1511	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of acetaldehyde upon cathepsin_G_and_chymase .
21687683	0	acetaldehyde	72,84	cathepsin_L	56,67	acetaldehyde	cathepsin L	MESH:D000079	1514	Chemical	Gene	role|nmod|START_ENTITY role|nmod|regulation regulation|nmod|END_ENTITY	Down regulation of a matrix degrading cysteine protease cathepsin_L , by acetaldehyde : role of C/EBPa .
17084997	0	acetaldehyde	23,35	cytochrome_P450	60,75	acetaldehyde	cytochrome P450	MESH:D000079	4051	Chemical	Gene	isoforms|amod|START_ENTITY isoforms|amod|END_ENTITY	Ethanol oxidation into acetaldehyde by 16 recombinant human cytochrome_P450 isoforms : role of CYP2C isoforms in human liver microsomes .
8123704	0	acetaldehyde	11,23	glucose-6-phosphate_dehydrogenase	27,60	acetaldehyde	glucose-6-phosphate dehydrogenase	MESH:D000079	24377(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effects of acetaldehyde on glucose-6-phosphate_dehydrogenase activity and mRNA levels in primary rat hepatocytes in culture .
2979011	0	acetaldehyde	27,39	plasmin	44,51	acetaldehyde	plasmin	MESH:D000079	5340	Chemical	Gene	START_ENTITY|dobj|activity activity|compound|END_ENTITY	-LSB- Inhibition by ethanol and acetaldehyde the plasmin activity and plasminogen activation induced by urokinase and streptokinase -RSB- .
26735791	0	acetaldehyde	14,26	transketolase	42,55	acetaldehyde	transketolase	MESH:D000079	7086	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nsubj|effect	The effect of acetaldehyde on human brain transketolase activity .
26689740	0	acetamidines	63,75	NOS	13,16	acetamidines	NOS	null	4843	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Screening of NOS activity and selectivity of newly synthesized acetamidines using RP-HPLC .
26236050	0	acetamidopyranosides	46,66	toll-like_receptor_4	84,104	acetamidopyranosides	toll-like receptor 4	null	21898(Tax:10090)	Chemical	Gene	Synthesis|nmod|START_ENTITY Synthesis|nmod|END_ENTITY	Synthesis of anti-inflammatory a-and b-linked acetamidopyranosides as inhibitors of toll-like_receptor_4 -LRB- TLR4 -RRB- .
24631341	0	acetaminophen	14,27	BCRP	49,53	acetaminophen	BCRP	MESH:D000082	644079	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	The effect of acetaminophen on the expression of BCRP in trophoblast cells impairs the placental barrier to bile_acids during maternal cholestasis .
19580839	0	acetaminophen	51,64	CB1	69,72	acetaminophen	CB1	MESH:D000082	12801(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|receptors receptors|nummod|END_ENTITY	Endocannabinoids mediate anxiolytic-like effect of acetaminophen via CB1 receptors .
9618435	0	acetaminophen	119,132	CYP2A5	68,74	acetaminophen	CYP2A5	MESH:D000082	13087(Tax:10090)	Chemical	Gene	activation|nmod|START_ENTITY role|nmod|activation END_ENTITY|dep|role	Purification and characterization of heterologously expressed mouse CYP2A5 and CYP2G1 : role in metabolic activation of acetaminophen and 2,6-dichlorobenzonitrile in mouse olfactory mucosal microsomes .
9714300	0	acetaminophen	26,39	CYP2A5	8,14	acetaminophen	CYP2A5	MESH:D000082	13087(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY Role|nmod|metabolism Role|nmod|END_ENTITY	Role of CYP2A5 and 2G1 in acetaminophen metabolism and toxicity in the olfactory mucosa of the Cyp1a2 -LRB- - / - -RRB- mouse .
10741631	0	acetaminophen	36,49	CYP2E1	16,22	acetaminophen	CYP2E1	MESH:D000082	1571	Chemical	Gene	Contribution|nmod|START_ENTITY Contribution|nmod|END_ENTITY	Contribution of CYP2E1 and CYP3A to acetaminophen reactive metabolite formation .
17620348	0	acetaminophen	50,63	CYP2E1	21,27	acetaminophen	CYP2E1	MESH:D000082	25086(Tax:10116)	Chemical	Gene	dose|nmod|START_ENTITY END_ENTITY|nmod|dose	Induction of hepatic CYP2E1 by a subtoxic dose of acetaminophen in rats : increase in dichloromethane metabolism and carboxyhemoglobin elevation .
8387297	0	acetaminophen	13,26	CYP3A4	74,80	acetaminophen	CYP3A4	MESH:D000082	1576	Chemical	Gene	Oxidation|nmod|START_ENTITY Oxidation|nmod|END_ENTITY	Oxidation of acetaminophen to N-acetyl-p-aminobenzoquinone_imine by human CYP3A4 .
20638381	0	acetaminophen	51,64	Endothelin-A_receptor	0,21	acetaminophen	Endothelin-A receptor	MESH:D000082	24326(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|potentiates potentiates|amod|END_ENTITY	Endothelin-A_receptor antagonist BQ123 potentiates acetaminophen induced hypothermia and reduces infarction following focal cerebral_ischemia in rats .
16530163	0	acetaminophen	46,59	HIF-1alpha	32,42	acetaminophen	HIF-1alpha	MESH:D000082	15251(Tax:10090)	Chemical	Gene	toxicity|compound|START_ENTITY END_ENTITY|nmod|toxicity	Induction of the nuclear factor HIF-1alpha in acetaminophen toxicity : evidence for oxidative stress .
20061376	0	acetaminophen	50,63	JNK	94,97	acetaminophen	JNK	MESH:D000082	26419(Tax:10090)	Chemical	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Silencing glycogen_synthase_kinase-3beta inhibits acetaminophen hepatotoxicity and attenuates JNK activation and loss of glutamate_cysteine ligase and myeloid_cell_leukemia_sequence_1 .
25575547	0	acetaminophen	33,46	NLRP3	95,100	acetaminophen	NLRP3	MESH:D000082	114548	Chemical	Gene	START_ENTITY|nmod|suppression suppression|nmod|END_ENTITY	The anti-inflammatory effects of acetaminophen and N-acetylcysteine through suppression of the NLRP3 inflammasome pathway in LPS-challenged piglet mononuclear phagocytes .
11134556	0	acetaminophen	42,55	Nrf2	20,24	acetaminophen	Nrf2	MESH:D000082	18024(Tax:10090)	Chemical	Gene	hepatotoxicity|compound|START_ENTITY mice|nmod|hepatotoxicity mice|amod|END_ENTITY	High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes .
11287661	0	acetaminophen	79,92	Nrf2	25,29	acetaminophen	Nrf2	MESH:D000082	18024(Tax:10090)	Chemical	Gene	detoxification|nmod|START_ENTITY function|dep|detoxification function|nmod|END_ENTITY	An important function of Nrf2 in combating oxidative stress : detoxification of acetaminophen .
15122755	0	acetaminophen	38,51	Nrf2	22,26	acetaminophen	Nrf2	MESH:D000082	18024(Tax:10090)	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of hepatic Nrf2 in vivo by acetaminophen in CD-1 mice .
17935745	0	acetaminophen	47,60	Nrf2	92,96	acetaminophen	Nrf2	MESH:D000082	18024(Tax:10090)	Chemical	Gene	transporters|nmod|START_ENTITY Induction|nmod|transporters dependent|nsubj|Induction dependent|nmod|END_ENTITY	Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2 .
26767949	0	acetaminophen	92,105	Nrf2	42,46	acetaminophen	Nrf2	MESH:D000082	4780	Chemical	Gene	axis|nmod|START_ENTITY axis|dep|stability stability|dep|END_ENTITY	PHLPP2 down regulation influences nuclear Nrf2 stability via Akt-1 / Gsk3b/Fyn kinase axis in acetaminophen induced oxidative renal_toxicity : Protection accorded by morin .
17526808	0	acetaminophen	10,23	P-glycoprotein	94,108	acetaminophen	P-glycoprotein	MESH:D000082	5243	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|parataxis|kinase kinase|nsubj|role role|nmod|protein protein|amod|END_ENTITY	High-dose acetaminophen inhibits the lethal effect of doxorubicin in HepG2 cells : the role of P-glycoprotein and mitogen-activated protein kinase p44/42 pathway .
26767949	0	acetaminophen	92,105	PHLPP2	0,6	acetaminophen	PHLPP2	MESH:D000082	23035	Chemical	Gene	axis|nmod|START_ENTITY axis|dep|stability stability|dep|END_ENTITY	PHLPP2 down regulation influences nuclear Nrf2 stability via Akt-1 / Gsk3b/Fyn kinase axis in acetaminophen induced oxidative renal_toxicity : Protection accorded by morin .
16532517	0	acetaminophen	57,70	Selenium-binding_protein_2	0,26	acetaminophen	Selenium-binding protein 2	MESH:D000082	20342(Tax:10090)	Chemical	Gene	target|nmod|START_ENTITY END_ENTITY|appos|target	Selenium-binding_protein_2 , the major hepatic target for acetaminophen , shows sex differences in protein abundance .
26227887	0	acetaminophen	41,54	TRPA1	0,5	acetaminophen	TRPA1	MESH:D000082	277328(Tax:10090)	Chemical	Gene	action|nmod|START_ENTITY mediates|dobj|action mediates|nsubj|END_ENTITY	TRPA1 mediates the hypothermic action of acetaminophen .
26850476	0	acetaminophen	27,40	Vanin-1	44,51	acetaminophen	Vanin-1	MESH:D000082	22361(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|compound|END_ENTITY	Enhanced hepatotoxicity by acetaminophen in Vanin-1 knockout mice is associated with deficient proliferative and immune responses .
3659572	0	acetaminophen	69,82	caffeine	11,19	acetaminophen	caffeine	MESH:D000082	104272(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of caffeine on biotransformation and elimination kinetics of acetaminophen in mice .
24263089	0	acetaminophen	23,36	connexin_32	8,19	acetaminophen	connexin 32	MESH:D000082	14618(Tax:10090)	Chemical	Gene	toxicity|compound|START_ENTITY END_ENTITY|nmod|toxicity	Role of connexin_32 in acetaminophen toxicity in a knockout mice model .
8085173	0	acetaminophen	53,66	epidermal_growth_factor	26,49	acetaminophen	epidermal growth factor	MESH:D000082	13645(Tax:10090)	Chemical	Gene	induced|compound|START_ENTITY END_ENTITY|nmod|induced	-LSB- Cytoprotective effect of epidermal_growth_factor on acetaminophen induced acute_injury_of_hepatocytes -RSB- .
9713578	0	acetaminophen	6,19	gamma-glutamyl_transferase	47,73	acetaminophen	gamma-glutamyl transferase	MESH:D000082	116568(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|activity activity|amod|END_ENTITY	Acute acetaminophen nephrotoxicity and urinary gamma-glutamyl_transferase activity in rats .
23907830	0	acetaminophen	47,60	insulin-like_growth_factor-1	90,118	acetaminophen	insulin-like growth factor-1	MESH:D000082	24482(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of administration of subtoxic doses of acetaminophen on liver and blood levels of insulin-like_growth_factor-1 in rats .
11557916	0	acetaminophen	43,56	interleukin_8	19,32	acetaminophen	interleukin 8	MESH:D000082	3576	Chemical	Gene	levels|nmod|START_ENTITY levels|amod|END_ENTITY	Elevation of serum interleukin_8 levels in acetaminophen overdose in children and adolescents .
20604837	0	acetaminophen	49,62	lysyl_hydroxylase_2	21,40	acetaminophen	lysyl hydroxylase 2	MESH:D000082	5352	Chemical	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Up-regulation of the lysyl_hydroxylase_2 gene by acetaminophen and isoniazid is modulated by transcription factor c-Myb .
7973799	0	acetaminophen	41,54	neurotensin	26,37	acetaminophen	neurotensin	MESH:D000082	67405(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	-LSB- Cytoprotective effect of neurotensin on acetaminophen induced liver_injury in relation to glutathione system -RSB- .
24386516	0	acetaminophen	18,31	nrf2	60,64	acetaminophen	nrf2	MESH:D000082	4780	Chemical	Gene	hepatotoxicity|compound|START_ENTITY updates|nmod|hepatotoxicity updates|dep|role role|nmod|END_ENTITY	Recent updates on acetaminophen hepatotoxicity : the role of nrf2 in hepatoprotection .
455818	0	acetaminophen	61,74	renin	7,12	acetaminophen	renin	MESH:D000082	5972	Chemical	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Plasma renin activity during the development of paracetamol -LRB- acetaminophen -RRB- induced acute_renal_failure in man .
23554142	0	acetaminophen	78,91	toll-like_receptor_4	8,28	acetaminophen	toll-like receptor 4	MESH:D000082	21898(Tax:10090)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of toll-like_receptor_4 in mediating multiorgan_dysfunction in mice with acetaminophen induced acute_liver_failure .
12773304	0	acetate	19,26	Insulin	0,7	acetate	Insulin	CHEBI:47622	3630	Chemical	Gene	metabolism|amod|START_ENTITY effects|nmod|metabolism effects|nsubj|END_ENTITY	Insulin effects on acetate metabolism .
7735905	0	acetate	61,68	Plasma_insulin_and_glucagon	0,27	acetate	Plasma insulin and glucagon	CHEBI:47622	397595(Tax:9823)	Chemical	Gene	responses|nmod|START_ENTITY responses|compound|END_ENTITY	Plasma_insulin_and_glucagon responses to acute challenges of acetate , propionate , n-butyrate and glucose in growing gilts -LRB- Sus_scrofa -RRB- .
7067169	0	acetate	76,83	growth_hormone	50,64	acetate	growth hormone	CHEBI:47622	2688	Chemical	Gene	release|nmod|START_ENTITY release|compound|END_ENTITY	Inhibition of arginine - and hypoglycemia - induced growth_hormone release by acetate in dialyzed patients .
10568477	0	acetate	44,51	insulin	90,97	acetate	insulin	CHEBI:47622	3630	Chemical	Gene	infusions|nmod|START_ENTITY Effects|nmod|infusions Effects|nmod|END_ENTITY	Effects of short - or long-term infusions of acetate or propionate on luteinizing hormone , insulin , and metabolite concentrations in beef heifers .
2083575	0	acetate	77,84	insulin	31,38	acetate	insulin	CHEBI:47622	105613195	Chemical	Gene	metabolism|amod|START_ENTITY hypothalamus|nmod|metabolism hypothalamus|nsubj|Influence Influence|nmod|microinjection microinjection|nmod|END_ENTITY	Influence of microinjection of insulin into the ventromedial hypothalamus on acetate metabolism in rumen epithelium of sheep .
23618232	0	acetate	17,24	insulin	70,77	acetate	insulin	CHEBI:47622	3630	Chemical	Gene	nanoparticles|compound|START_ENTITY use|nsubj|nanoparticles use|nmod|delivery delivery|compound|END_ENTITY	PEGylated starch acetate nanoparticles and its potential use for oral insulin delivery .
2864166	0	acetate	48,55	insulin	11,18	acetate	insulin	CHEBI:47622	105613195	Chemical	Gene	metabolism|nmod|START_ENTITY Effects|nmod|metabolism Effects|nmod|END_ENTITY	Effects of insulin on net hepatic metabolism of acetate and beta-hydroxybutyrate in sheep -LRB- Ovis_aries -RRB- .
3536539	0	acetate	67,74	insulin	31,38	acetate	insulin	CHEBI:47622	100009181(Tax:9986)	Chemical	Gene	metabolism|compound|START_ENTITY hippocampus|nmod|metabolism Influence|nmod|hippocampus Influence|nmod|microinjection microinjection|nmod|END_ENTITY	Influence of microinjection of insulin into hippocampus on hepatic acetate metabolism in rabbits .
3894041	0	acetate	73,80	insulin	31,38	acetate	insulin	CHEBI:47622	100009181(Tax:9986)	Chemical	Gene	metabolism|amod|START_ENTITY Influence|nmod|metabolism Influence|nmod|END_ENTITY	Influence of microinjection of insulin into ventromedial hypothalamus on acetate metabolism in liver slices of rabbit .
3937741	0	acetate	56,63	insulin	31,38	acetate	insulin	CHEBI:47622	100009181(Tax:9986)	Chemical	Gene	metabolism|amod|START_ENTITY Influence|nmod|metabolism Influence|nmod|END_ENTITY	Influence of microinjection of insulin into amygdala on acetate metabolism in liver slices of rabbit .
6751811	0	acetate	61,68	insulin	11,18	acetate	insulin	CHEBI:47622	3630	Chemical	Gene	synthesis|nmod|START_ENTITY Effects|nmod|synthesis Effects|nmod|END_ENTITY	Effects of insulin and glucagon on fatty_acid synthesis from acetate by hepatocytes incubated with -LRB----RRB- - hydroxycitrate .
6797910	0	acetate	21,28	insulin	10,17	acetate	insulin	CHEBI:47622	396145(Tax:9031)	Chemical	Gene	metabolism|amod|START_ENTITY Effect|nmod|metabolism Effect|nmod|END_ENTITY	Effect of insulin on acetate metabolism in chicken adipocytes .
12928006	0	acetate	11,18	leptin_receptor	75,90	acetate	leptin receptor	CHEBI:47622	497205(Tax:9913)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of acetate and butyrate on the expression of leptin and short-form leptin_receptor in bovine and rat anterior pituitary cells .
8396935	0	acetate	36,43	peripheral-type_benzodiazepine_receptor	57,96	acetate	peripheral-type benzodiazepine receptor	CHEBI:47622	12257(Tax:10090)	Chemical	Gene	modulate|nsubj|START_ENTITY modulate|dobj|END_ENTITY	Interleukin-1 and phorbol myristate acetate modulate the peripheral-type_benzodiazepine_receptor in lymphocytes and glial cells .
20512452	0	acetazolamide	94,107	Aquaporin-1	0,11	acetazolamide	Aquaporin-1	MESH:D000086	100008839(Tax:9986)	Chemical	Gene	decreased|nmod|START_ENTITY decreased|nsubjpass|expression expression|amod|END_ENTITY	Aquaporin-1 expression and angiogenesis in rabbit chronic myocardial_ischemia is decreased by acetazolamide .
23029347	0	acetazolamide	89,102	Aquaporin-1	0,11	acetazolamide	Aquaporin-1	MESH:D000086	11826(Tax:10090)	Chemical	Gene	mechanism|nmod|START_ENTITY mediates|dobj|mechanism mediates|nsubj|translocation translocation|compound|END_ENTITY	Aquaporin-1 translocation and degradation mediates the water transportation mechanism of acetazolamide .
12571143	0	acetazolamide	74,87	CO2	8,11	acetazolamide	CO2	MESH:D000086	717	Chemical	Gene	response|nmod|START_ENTITY chemoreception|dep|response chemoreception|compound|END_ENTITY	Central CO2 chemoreception in developing bullfrogs : anomalous response to acetazolamide .
1727137	0	acetazolamide	98,111	CO2	91,94	acetazolamide	CO2	MESH:D000086	717	Chemical	Gene	comparison|acl|START_ENTITY comparison|nmod|END_ENTITY	Evaluation of cerebral vasomotor reactivity by various vasodilating stimuli : comparison of CO2 to acetazolamide .
2506385	0	acetazolamide	63,76	CO2	1,4	acetazolamide	CO2	MESH:D000086	717	Chemical	Gene	-RSB-|amod|START_ENTITY administration|nmod|-RSB- elimination|nmod|administration elimination|nsubj|END_ENTITY	-LSB- CO2 elimination in ophthalmic surgery after administration of acetazolamide -RSB- .
3095575	0	acetazolamide	29,42	CO2	102,105	acetazolamide	CO2	MESH:D000086	717	Chemical	Gene	acidosis|amod|START_ENTITY effects|nmod|acidosis Difference|nmod|effects Difference|nmod|END_ENTITY	Difference in the effects of acetazolamide and ammonium_chloride acidosis on ventilatory responses to CO2 and hypoxia in humans .
9877476	0	acetazolamide	19,32	CO2	52,55	acetazolamide	CO2	MESH:D000086	717	Chemical	Gene	START_ENTITY|nmod|response response|compound|END_ENTITY	Effect of low-dose acetazolamide on the ventilatory CO2 response during hypoxia in the anaesthetized cat .
10586621	0	acetazolamide	21,34	SCA6	39,43	acetazolamide	SCA6	MESH:D000086	773	Chemical	Gene	START_ENTITY|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- A clinical trial of acetazolamide for SCA6 -RSB- .
22116425	0	acetazolamide	10,23	aquaporin-1	27,38	acetazolamide	aquaporin-1	MESH:D000086	25240(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|flow flow|amod|END_ENTITY	Effect of acetazolamide on aquaporin-1 and fluid flow in cultured choroid_plexus .
19851004	0	acetazolamide	72,85	carbonic_anhydrase_II	35,56	acetazolamide	carbonic anhydrase II	MESH:D000086	760	Chemical	Gene	complexed|nmod|START_ENTITY END_ENTITY|acl|complexed	High-resolution structure of human carbonic_anhydrase_II complexed with acetazolamide reveals insights into inhibitor drug design .
2128470	0	acetazolamide	25,38	carbonic_anhydrase_II	56,77	acetazolamide	carbonic anhydrase II	MESH:D000086	760	Chemical	Gene	complex|amod|START_ENTITY complex|nmod|END_ENTITY	Refined structure of the acetazolamide complex of human carbonic_anhydrase_II at 1.9 A .
18618712	0	acetazolamide	86,99	carbonic_anhydrase_XIII	27,50	acetazolamide	carbonic anhydrase XIII	MESH:D000086	377677	Chemical	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Crystal structure of human carbonic_anhydrase_XIII and its complex with the inhibitor acetazolamide .
605775	0	acetazolamide	67,80	insulin	18,25	acetazolamide	insulin	MESH:D000086	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|concentrations concentrations|compound|END_ENTITY	Effect upon serum insulin , glucose and potassium concentrations of acetazolamide during attacks of familial periodic hypokalemic_paralysis .
6378152	0	acetazolamide	10,23	insulin	27,34	acetazolamide	insulin	MESH:D000086	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|sensitivity sensitivity|compound|END_ENTITY	Effect of acetazolamide on insulin sensitivity in myotonic_disorders .
710688	0	acetazolamide	10,23	pyruvate_carboxylase	33,53	acetazolamide	pyruvate carboxylase	MESH:D000086	18563(Tax:10090)	Chemical	Gene	Action|nmod|START_ENTITY END_ENTITY|nsubj|Action	Action of acetazolamide on liver pyruvate_carboxylase activity , glycogenolysis and gluconeogenesis of mice .
8866753	0	aceteoside	103,113	intercellular_adhesion_molecule-1	131,164	aceteoside	intercellular adhesion molecule-1	null	25464(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|cells cells|amod|END_ENTITY	Acteoside , a component of Stachys sieboldii MIQ , may be a promising antinephritic agent -LRB- 3 -RRB- : effect of aceteoside on expression of intercellular_adhesion_molecule-1 in experimental nephritic glomeruli in rats and cultured endothelial cells .
24152122	0	acetic_acid	155,166	DGAT-1	176,182	acetic acid	DGAT-1	MESH:D019342	8694	Chemical	Gene	inhibitor|advcl|START_ENTITY inhibitor|nsubj|END_ENTITY	Preclinical pharmacokinetic characterization of 2 - -LRB- 4 - -LRB- 4 - -LRB- 5 - -LRB- 2-phenyl-5 - -LRB- trifluoromethyl -RRB- oxazole-4-carboxamido -RRB- -1 H-benzo -LSB- d -RSB- imidazol-2-yl -RRB- phenyl -RRB- cyclohexyl -RRB- acetic_acid , a novel DGAT-1 inhibitor .
17620418	7	acetic_acid	1631,1642	Hog1	1623,1627	acetic acid	Hog1	MESH:D019342	850803(Tax:4932)	Chemical	Gene	resistance|amod|START_ENTITY END_ENTITY|nmod|resistance	Remarkably , targetting of Fps1 for degradation may be the major requirement for an active Hog1 in acetic_acid resistance , since Hog1 is largely dispensable for such resistance when the cells lack Fps1 .
26479519	0	acetic_acid	89,100	SET5	122,126	acetic acid	SET5	MESH:D019342	856614(Tax:4932)	Chemical	Gene	START_ENTITY|nmod|overexpression overexpression|nmod|END_ENTITY	Improved growth and ethanol fermentation of ISaccharomyces_cerevisiae in the presence of acetic_acid by overexpression of SET5 and PPR1 .
26579580	0	acetic_acid	53,64	nesfatin-1	29,39	acetic acid	nesfatin-1	MESH:D019342	59295(Tax:10116)	Chemical	Gene	rats|nmod|START_ENTITY END_ENTITY|nmod|rats	Anti-inflammatory effects of nesfatin-1 in rats with acetic_acid - induced colitis and underlying mechanisms .
8830047	0	acetoacetyl-CoA	75,90	medium-chain_acyl-CoA_dehydrogenase	34,69	acetoacetyl-CoA	medium-chain acyl-CoA dehydrogenase	MESH:C010667	397104(Tax:9823)	Chemical	Gene	study|nmod|START_ENTITY study|nmod|interaction interaction|nmod|END_ENTITY	C-NMR study on the interaction of medium-chain_acyl-CoA_dehydrogenase with acetoacetyl-CoA .
11812788	0	acetoacetyl-CoA	75,90	short_chain_acyl-CoA_dehydrogenase	25,59	acetoacetyl-CoA	short chain acyl-CoA dehydrogenase	MESH:C010667	64304(Tax:10116)	Chemical	Gene	complexed|nmod|START_ENTITY END_ENTITY|acl|complexed	Crystal structure of rat short_chain_acyl-CoA_dehydrogenase complexed with acetoacetyl-CoA : comparison with other acyl-CoA dehydrogenases .
8013281	0	acetone	75,82	CYP2E1	28,34	acetone	CYP2E1	MESH:D000096	13106(Tax:10090)	Chemical	Gene	administration|compound|START_ENTITY Induction|nmod|administration Induction|nmod|END_ENTITY	Induction and regulation of CYP2E1 in murine liver after acute and chronic acetone administration .
16433043	0	acetone	60,67	Ha-ras	114,120	acetone	Ha-ras	MESH:D000096	15461(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|activity activity|compound|END_ENTITY	Effect of the chalcone analog E,E-bis -LRB- 2-hydroxybenzylidene -RRB- acetone on the 7,12-dimethylbenz -LSB- a -RSB- anthracene-induced Ha-ras gene activity in vivo .
7875939	0	acetone	41,48	cyclosporin_A	24,37	acetone	cyclosporin A	MESH:D000096	1161	Chemical	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	Conformational study of cyclosporin_A in acetone at low temperature .
8205967	0	acetone	10,17	milk	29,33	acetone	milk	MESH:D000096	100532204	Chemical	Gene	content|amod|START_ENTITY content|nmod|END_ENTITY	-LSB- Urea and acetone content in milk as indicators for nutritionally caused fertility disorders of dairy cows -RSB- .
23802426	0	acetophenone	48,60	acetylcholinesterase	89,109	acetophenone	acetylcholinesterase	MESH:C038699	43	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|inhibitors inhibitors|compound|END_ENTITY	Design , synthesis , and biological evaluation of acetophenone derivatives as dual binding acetylcholinesterase inhibitors .
18006320	0	acetophenones	43,56	3alpha-hydroxysteroid_dehydrogenase	86,121	acetophenones	3alpha-hydroxysteroid dehydrogenase	MESH:D000098	291283(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|reaction reaction|nmod|END_ENTITY	Electronic effects of para-substitution on acetophenones in the reaction of rat liver 3alpha-hydroxysteroid_dehydrogenase .
1350927	0	acetorphan	11,21	enkephalinase	41,54	acetorphan	enkephalinase	MESH:C049331	4311	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Effects of acetorphan , an antidiarrhoeal enkephalinase inhibitor , on oro-caecal and colonic transit times in healthy volunteers .
1624154	0	acetorphan	11,21	enkephalinase	26,39	acetorphan	enkephalinase	MESH:C049331	4311	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effects of acetorphan , an enkephalinase inhibitor , on experimental and acute diarrhoea .
1780043	0	acetorphan	128,138	enkephalinase	22,35	acetorphan	enkephalinase	MESH:C049331	24590(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY changes|nmod|effects induces|dobj|changes induces|nsubj|inhibition inhibition|nmod|END_ENTITY	Chronic inhibition of enkephalinase induces changes in the antinociceptive and locomotor effects of the enkephalinase inhibitor acetorphan in rats .
2591688	0	acetorphan	65,75	enkephalinase	93,106	acetorphan	enkephalinase	MESH:C049331	4311	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Non-cholinergic neural excitation of the human rectum induced by acetorphan , an inhibitor of enkephalinase .
2702924	0	acetorphan	37,47	enkephalinase	52,65	acetorphan	enkephalinase	MESH:C049331	24590(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Assessment of the abuse potential of acetorphan , an enkephalinase inhibitor .
2758762	0	acetorphan	115,125	enkephalinase	130,143	acetorphan	enkephalinase	MESH:C049331	4311	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Naloxone-reversible inhibition of gall-bladder mucosal fluid secretion in experimental cholecystitis in the cat by acetorphan , an enkephalinase inhibitor .
3121843	0	acetorphan	58,68	enkephalinase	74,87	acetorphan	enkephalinase	MESH:C049331	24590(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Role of endogenous enkephalins in locomotion evidenced by acetorphan , an `` enkephalinase '' inhibitor .
8488368	0	acetorphan	29,39	enkephalinase	4,17	acetorphan	enkephalinase	MESH:C049331	4311	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	The enkephalinase inhibitor , acetorphan , in acute diarrhoea .
18047370	0	acetoxy	53,60	C10	49,52	acetoxy	C10	CHEBI:48076	3226	Chemical	Gene	group|compound|START_ENTITY group|compound|END_ENTITY	Fluorinated alcohol mediated displacement of the C10 acetoxy group of benzo -LSB- a -RSB- pyrene-7 ,8,9,10 - tetrahydrotetraol_tetraacetates : a new route to diol_epoxide-deoxyguanosine adducts .
18442799	0	acetoxycycloheximide	96,116	TNF_receptor_1	70,84	acetoxycycloheximide	TNF receptor 1	MESH:C004434	7132	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	ERK and p38_MAP_kinase are involved in downregulation of cell surface TNF_receptor_1 induced by acetoxycycloheximide .
19710473	0	acetyl	33,39	FIBCD1	20,26	acetyl	FIBCD1	CHEBI:40574	84929	Chemical	Gene	receptor|amod|START_ENTITY END_ENTITY|nmod|receptor	Characterization of FIBCD1 as an acetyl group-binding receptor that binds chitin .
23194864	0	acetyl-11-keto-b-boswellic_acid	29,60	5-Lipoxygenase	0,14	acetyl-11-keto-b-boswellic acid	5-Lipoxygenase	null	240	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	5-Lipoxygenase inhibition by acetyl-11-keto-b-boswellic_acid -LRB- AKBA -RRB- by a novel mechanism .
9760176	0	acetyl-11-keto-beta-boswellic_acid	23,57	5-lipoxygenase	102,116	acetyl-11-keto-beta-boswellic acid	5-lipoxygenase	MESH:C094432	240	Chemical	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Characterization of an acetyl-11-keto-beta-boswellic_acid and arachidonate-binding regulatory site of 5-lipoxygenase using photoaffinity labeling .
18032778	0	acetyl-11-keto-beta-boswellic_acid	72,106	ApoE	125,129	acetyl-11-keto-beta-boswellic acid	ApoE	MESH:C094432	11816(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Antiinflammatory and antiatherogenic effects of the NF-kappaB inhibitor acetyl-11-keto-beta-boswellic_acid in LPS-challenged ApoE - / - mice .
18430409	0	acetyl-11-keto-beta-boswellic_acid	21,55	Sp1	96,99	acetyl-11-keto-beta-boswellic acid	Sp1	MESH:C094432	6667	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|amod|END_ENTITY	Inhibitory effect of acetyl-11-keto-beta-boswellic_acid on androgen_receptor by interference of Sp1 binding activity in prostate_cancer cells .
18430409	0	acetyl-11-keto-beta-boswellic_acid	21,55	androgen_receptor	59,76	acetyl-11-keto-beta-boswellic acid	androgen receptor	MESH:C094432	367	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Inhibitory effect of acetyl-11-keto-beta-boswellic_acid on androgen_receptor by interference of Sp1 binding activity in prostate_cancer cells .
9045680	0	acetyl-Asp-Val-Ala-Asp_fluoromethyl_ketone	70,112	CPP32	31,36	acetyl-Asp-Val-Ala-Asp fluoromethyl ketone	CPP32	null	836	Chemical	Gene	Structure|nmod|START_ENTITY Structure|nmod|END_ENTITY	Structure of recombinant human CPP32 in complex with the tetrapeptide acetyl-Asp-Val-Ala-Asp_fluoromethyl_ketone .
20826464	0	acetyl-CoA	24,34	AT-1	0,4	acetyl-CoA	AT-1	MESH:D000105	64018(Tax:10116)	Chemical	Gene	transporter|amod|START_ENTITY transporter|nsubj|END_ENTITY	AT-1 is the ER membrane acetyl-CoA transporter and is essential for cell viability .
3732509	0	acetyl-CoA	83,93	Avidin	0,6	acetyl-CoA	Avidin	MESH:D000105	396260(Tax:9031)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|END_ENTITY	Avidin as a probe of the conformational changes induced in pyruvate_carboxylase by acetyl-CoA and pyruvate .
8103051	0	acetyl-CoA	18,28	INS-1	89,94	acetyl-CoA	INS-1	MESH:D000105	2305	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|line line|appos|END_ENTITY	Glucose regulates acetyl-CoA carboxylase gene expression in a pancreatic beta-cell line -LRB- INS-1 -RRB- .
9032094	0	acetyl-CoA	31,41	INS-1	103,108	acetyl-CoA	INS-1	MESH:D000105	2305	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Long-chain fatty_acids inhibit acetyl-CoA carboxylase gene expression in the pancreatic beta-cell line INS-1 .
7492547	0	acetyl-CoA	52,62	citrate_synthase	80,96	acetyl-CoA	citrate synthase	MESH:D000105	1431	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	alpha-Fluoro_acid and alpha-fluoro_amide analogs of acetyl-CoA as inhibitors of citrate_synthase : effect of pKa matching on binding affinity and hydrogen bond length .
21638027	0	acetyl-CoA	45,55	insulin-like_growth_factor-1	13,41	acetyl-CoA	insulin-like growth factor-1	MESH:D000105	3479	Chemical	Gene	activity|amod|START_ENTITY END_ENTITY|nmod|activity	Dual role of insulin-like_growth_factor-1 in acetyl-CoA carboxylase-alpha activity in human colon_cancer cells HCT-8 : downregulating its expression and phosphorylation .
1982438	0	acetyl-CoA	27,37	prolactin	14,23	acetyl-CoA	prolactin	MESH:D000105	443317(Tax:9940)	Chemical	Gene	activity|amod|START_ENTITY END_ENTITY|nmod|activity	The effect of prolactin on acetyl-CoA carboxylase activity in mammary explants from pregnant sheep .
1390726	0	acetyl-CoA	62,72	pyruvate_carboxylase	87,107	acetyl-CoA	pyruvate carboxylase	MESH:D000105	374263(Tax:9031)	Chemical	Gene	action|amod|START_ENTITY Isolation|nmod|action Isolation|nmod|reaction reaction|amod|END_ENTITY	Isolation of a carboxyphosphate intermediate and the locus of acetyl-CoA action in the pyruvate_carboxylase reaction .
3732509	0	acetyl-CoA	83,93	pyruvate_carboxylase	59,79	acetyl-CoA	pyruvate carboxylase	MESH:D000105	374263(Tax:9031)	Chemical	Gene	induced|nmod|START_ENTITY induced|nmod|END_ENTITY	Avidin as a probe of the conformational changes induced in pyruvate_carboxylase by acetyl-CoA and pyruvate .
5967113	0	acetyl-CoA	32,42	pyruvate_carboxylase	59,79	acetyl-CoA	pyruvate carboxylase	MESH:D000105	101107484	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nsubj|effect	Apparent co-operative effect of acetyl-CoA on sheep kidney pyruvate_carboxylase .
833128	0	acetyl-CoA	11,21	pyruvate_carboxylase	39,59	acetyl-CoA	pyruvate carboxylase	MESH:D000105	374263(Tax:9031)	Chemical	Gene	Binding|nmod|START_ENTITY END_ENTITY|nsubj|Binding	Binding of acetyl-CoA to chicken liver pyruvate_carboxylase .
19684012	0	acetyl-L-carnitine	41,59	OCTN2	15,20	acetyl-L-carnitine	OCTN2	MESH:D000108	29726(Tax:10116)	Chemical	Gene	transport|nmod|START_ENTITY Involvement|nmod|transport Involvement|nmod|END_ENTITY	Involvement of OCTN2 in the transport of acetyl-L-carnitine across the inner blood-retinal barrier .
21590285	0	acetyl-L-carnitine	63,81	artemin	30,37	acetyl-L-carnitine	artemin	MESH:D000108	11876(Tax:10090)	Chemical	Gene	activity|amod|START_ENTITY mechanism|nmod|activity effect|dep|mechanism effect|nmod|END_ENTITY	Antidepressant-like effect of artemin in mice : a mechanism for acetyl-L-carnitine activity on depression .
18761385	0	acetyl-L-carnitine	58,76	kinesin_light-chain_1	17,38	acetyl-L-carnitine	kinesin light-chain 1	MESH:D000108	171041(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Up-regulation of kinesin_light-chain_1 gene expression by acetyl-L-carnitine : therapeutic possibility in Alzheimer 's _ disease .
21614517	0	acetyl-L-carnitine	54,72	myelin_basic_protein	14,34	acetyl-L-carnitine	myelin basic protein	MESH:D000108	24547(Tax:10116)	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|expression expression|amod|END_ENTITY	Modulation of myelin_basic_protein gene expression by acetyl-L-carnitine .
1324679	0	acetyl-L-carnitine	56,74	nerve_growth_factor	15,34	acetyl-L-carnitine	nerve growth factor	MESH:D000108	310738(Tax:10116)	Chemical	Gene	Stimulation|nmod|START_ENTITY Stimulation|nmod|receptors receptors|compound|END_ENTITY	Stimulation of nerve_growth_factor receptors in PC12 by acetyl-L-carnitine .
20459025	0	acetyl-L-carnitine	11,29	tumor_necrosis_factor-alpha	79,106	acetyl-L-carnitine	tumor necrosis factor-alpha	MESH:D000108	24835(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY induced|nsubj|Effect induced|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Effect of acetyl-L-carnitine on the insulin resistance of L6 cells induced by tumor_necrosis_factor-alpha -RSB- .
10565814	0	acetyl-Ser-Asp-Lys-Pro	121,143	angiotensin-converting_enzyme	10,39	acetyl-Ser-Asp-Lys-Pro	angiotensin-converting enzyme	null	24310(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|inhibition inhibition|amod|END_ENTITY	Effect of angiotensin-converting_enzyme inhibition on plasma , urine , and tissue concentrations of hemoregulatory peptide acetyl-Ser-Asp-Lys-Pro in rats .
22612976	0	acetyl-coenzyme_A	40,57	ACAA2	77,82	acetyl-coenzyme A	ACAA2	MESH:D000105	101111925	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	A single nucleotide polymorphism in the acetyl-coenzyme_A acyltransferase 2 -LRB- ACAA2 -RRB- gene is associated with milk yield in Chios sheep .
20519229	0	acetyl-coenzyme_A	4,21	ACACB	40,45	acetyl-coenzyme A	ACACB	MESH:D000105	32	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The acetyl-coenzyme_A carboxylase beta -LRB- ACACB -RRB- gene is associated with nephropathy in Chinese patients with type 2 diabetes .
1220678	1	acetyl-coenzyme_A	60,77	carnitine_acetyltransferase	117,144	acetyl-coenzyme A	carnitine acetyltransferase	MESH:D000105	311849(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|action action|nmod|END_ENTITY	The conversion of acetyl-coenzyme_A into acetate by the combined action of carnitine_acetyltransferase and acetylcarnitine hydrolase .
4370896	0	acetyl-coenzyme_A	14,31	phosphate-activated_glutaminase	35,66	acetyl-coenzyme A	phosphate-activated glutaminase	MESH:D000105	399525(Tax:9823)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of acetyl-coenzyme_A on phosphate-activated_glutaminase from pig kidney and brain .
25463525	0	acetyl-l-carnitine	44,62	VGF	89,92	acetyl-l-carnitine	VGF	MESH:D000108	381677(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY mediated|nsubj|effects mediated|nmod|END_ENTITY	Rapid-acting antidepressant-like effects of acetyl-l-carnitine mediated by PI3K/AKT/BDNF / VGF signaling pathway in mice .
26731611	0	acetyl-lysine	79,92	BRD4	113,117	acetyl-lysine	BRD4	null	23476	Chemical	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	4-acyl_pyrrole derivatives yield novel vectors for designing inhibitors of the acetyl-lysine recognition site of BRD4 -LRB- 1 -RRB- .
288344	0	acetyl-phenylhydrazide	50,72	Monoamine_oxidase	0,17	acetyl-phenylhydrazide	Monoamine oxidase	null	29253(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|dobj|effects	Monoamine_oxidase inhibiting and toxic effects of acetyl-phenylhydrazide on rat liver in vivo .
8251494	0	acetyl_CoA	19,29	pyruvate_carboxylase	70,90	acetyl CoA	pyruvate carboxylase	MESH:D000105	5091	Chemical	Gene	Locus|nmod|START_ENTITY Locus|nmod|reaction reaction|nmod|END_ENTITY	Locus of action of acetyl_CoA in the biotin-carboxylation reaction of pyruvate_carboxylase .
8620009	0	acetyl_CoA	11,21	pyruvate_carboxylase	95,115	acetyl CoA	pyruvate carboxylase	MESH:D000105	5091	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of acetyl_CoA on the pre-steady-state kinetics of the biotin carboxylation reaction of pyruvate_carboxylase .
12130639	0	acetyl_phosphate	89,105	ATPase	63,69	acetyl phosphate	ATPase	MESH:C011632	1769	Chemical	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	Dissecting the hydrolytic activities of sarcoplasmic reticulum ATPase in the presence of acetyl_phosphate .
3036067	0	acetyl_phosphate	15,31	phosphoenolpyruvate_carboxylase	66,97	acetyl phosphate	phosphoenolpyruvate carboxylase	MESH:C011632	5105	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of acetyl_phosphate and carbamyl_phosphate with plant phosphoenolpyruvate_carboxylase .
6188232	0	acetyl_salicylic_acid	21,42	thrombin	11,19	acetyl salicylic acid	thrombin	MESH:D001241	2147	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of thrombin , acetyl_salicylic_acid and prostaglandins on spontaneous efflux of norepinephrine and beta-thromboglobulin from platelets in calcium/magnesium deficient environment .
6861274	0	acetylaminofluorene	108,127	cytochrome_P-450	70,86	acetylaminofluorene	cytochrome P-450	MESH:D015073	4051	Chemical	Gene	metabolism|nmod|START_ENTITY END_ENTITY|nmod|metabolism	Kinetic evidence for the involvement of multiple forms of human liver cytochrome_P-450 in the metabolism of acetylaminofluorene .
11769569	0	acetylcholine	121,134	5-HT1A	10,16	acetylcholine	5-HT1A	MESH:D000109	24473(Tax:10116)	Chemical	Gene	concentrations|compound|START_ENTITY increased|dobj|concentrations increased|nsubj|agonist agonist|nummod|END_ENTITY	Selective 5-HT1A receptor agonist , 8-OH-DPAT , locally administered into the dorsal raphe nucleus increased extracellular acetylcholine concentrations in the medial prefrontal cortex of conscious rats .
2138087	0	acetylcholine	71,84	5-HT1A	34,40	acetylcholine	5-HT1A	MESH:D000109	100301563(Tax:10141)	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|8-OH-DPAT 8-OH-DPAT|appos|agonist agonist|amod|END_ENTITY	Different effects of 8-OH-DPAT , a 5-HT1A receptor agonist , on cortical acetylcholine release , electrocortigram and body temperature in guinea_pigs and rats .
7813581	0	acetylcholine	22,35	5-HT1A	0,6	acetylcholine	5-HT1A	MESH:D000109	3350	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	5-HT1A and muscarinic acetylcholine receptors jointly regulate passive avoidance behavior .
8158130	0	acetylcholine	47,60	5-HT1A	22,28	acetylcholine	5-HT1A	MESH:D000109	24473(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY enhances|dobj|release enhances|nsubj|receptor receptor|nummod|END_ENTITY	Hippocampal serotonin 5-HT1A receptor enhances acetylcholine release in conscious rats .
8793911	0	acetylcholine	39,52	5-HT1A	0,6	acetylcholine	5-HT1A	MESH:D000109	100301563(Tax:10141)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nummod|END_ENTITY	5-HT1A receptor-mediated inhibition of acetylcholine release from guinea_pig myenteric plexus : potential mechanisms .
9517445	0	acetylcholine	63,76	5-HT1A	17,23	acetylcholine	5-HT1A	MESH:D000109	24473(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY facilitates|dobj|release facilitates|nsubj|MKC-242 MKC-242|appos|agonist agonist|nummod|END_ENTITY	MKC-242 , a novel 5-HT1A receptor agonist , facilitates cortical acetylcholine release by a mechanism different from that of 8-OH-DPAT in awake rats .
8627564	0	acetylcholine	41,54	5-HT_1B	93,100	acetylcholine	5-HT 1B	MESH:D000109	25075(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|receptors receptors|nummod|END_ENTITY	Endogenous serotonin facilitates in vivo acetylcholine release in rat frontal cortex through 5-HT_1B receptors .
9606719	0	acetylcholine	42,55	ACR-3	0,5	acetylcholine	ACR-3	MESH:D000109	180937(Tax:6239)	Chemical	Gene	subunit|amod|START_ENTITY END_ENTITY|appos|subunit	ACR-3 , a Caenorhabditis_elegans nicotinic acetylcholine receptor subunit .
7857642	0	acetylcholine	18,31	ARIA	77,81	acetylcholine	ARIA	MESH:D000109	211323(Tax:10090)	Chemical	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Regulation of the acetylcholine receptor epsilon subunit gene by recombinant ARIA : an in vitro model for transynaptic gene regulation .
11176279	0	acetylcholine	117,130	Acetylcholinesterase	0,20	acetylcholine	Acetylcholinesterase	MESH:D000109	83817(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY piperidyl_benzilate|nmod|receptors increases|dep|piperidyl_benzilate increases|amod|END_ENTITY	Acetylcholinesterase inhibition increases in vivo N - -LRB- 2 - -LSB- 18F -RSB- fluoroethyl -RRB- -4 - piperidyl_benzilate binding to muscarinic acetylcholine receptors .
19248156	0	acetylcholine	71,84	Acetylcholinesterase	0,20	acetylcholine	Acetylcholinesterase	MESH:D000109	83817(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	Acetylcholinesterase activity , choline_acetyltransferase and vesicular acetylcholine transporter immunoreactivities in the rat adrenal gland during postnatal development .
22148672	0	acetylcholine	121,134	Acetylcholinesterase	0,20	acetylcholine	Acetylcholinesterase	MESH:D000109	43	Chemical	Gene	detection|nmod|START_ENTITY nanoparticles|nmod|detection growth|nmod|nanoparticles END_ENTITY|advcl|growth	Acetylcholinesterase liquid crystal biosensor based on modulated growth of gold nanoparticles for amplified detection of acetylcholine and inhibitor .
18991851	0	acetylcholine	48,61	Alpha4	0,6	acetylcholine	Alpha4	MESH:D000109	3476	Chemical	Gene	genes|compound|START_ENTITY subunits|nmod|genes subunits|amod|END_ENTITY	Alpha4 and beta2 subunits of neuronal nicotinic acetylcholine receptor genes are not associated with methamphetamine-use disorder in the Japanese population .
2337775	0	acetylcholine	24,37	Angiotensin_II	0,14	acetylcholine	Angiotensin II	MESH:D000109	183	Chemical	Gene	release|amod|START_ENTITY inhibits|dobj|release inhibits|nsubj|END_ENTITY	Angiotensin_II inhibits acetylcholine release from human temporal cortex : implications for cognition .
17584502	0	acetylcholine	25,38	Beta2	0,5	acetylcholine	Beta2	MESH:D000109	15130(Tax:10090)	Chemical	Gene	receptors|amod|START_ENTITY mediate|nsubj|receptors containing|ccomp|mediate subunit|xcomp|containing subunit|nsubj|END_ENTITY	Beta2 subunit containing acetylcholine receptors mediate nicotine withdrawal_deficits in the acquisition of contextual_fear_conditioning .
16248884	0	acetylcholine	186,199	CA1	117,120	acetylcholine	CA1	MESH:D000109	310218(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY hippocampus|nmod|receptors END_ENTITY|nmod|hippocampus	8 - -LSB- 2 - -LRB- 2-pentyl-cyclopropylmethyl -RRB- - cyclopropyl -RSB- - octanoic_acid stimulates GABA release from interneurons projecting to CA1 pyramidal neurons in the rat hippocampus via pre-synaptic alpha7 acetylcholine receptors .
23015319	0	acetylcholine	39,52	CA1	116,119	acetylcholine	CA1	MESH:D000109	310218(Tax:10116)	Chemical	Gene	currents|amod|START_ENTITY currents|nmod|neurons neurons|compound|END_ENTITY	Amyloid b-protein suppressed nicotinic acetylcholine receptor-mediated currents in acutely isolated rat hippocampal CA1 pyramidal neurons .
21246223	0	acetylcholine	14,27	CA3	83,86	acetylcholine	CA3	MESH:D000109	54232(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of acetylcholine on pain-related electric activities in the hippocampal CA3 of rats .
22490561	0	acetylcholine	14,27	CA3	85,88	acetylcholine	CA3	MESH:D000109	12350(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY regulate|nsubj|receptors regulate|nmod|synapses synapses|compound|END_ENTITY	M2 muscarinic acetylcholine receptors regulate long-term potentiation at hippocampal CA3 pyramidal cell synapses in an input-specific fashion .
26351557	0	acetylcholine	10,23	CA3	95,98	acetylcholine	CA3	MESH:D000109	54232(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY Effect|nmod|receptors Effect|nmod|region region|compound|END_ENTITY	Effect of acetylcholine receptors on the pain-related electrical activities in the hippocampal CA3 region of morphine-addicted rats .
12406580	0	acetylcholine	66,79	CHNRA6	105,111	acetylcholine	CHNRA6	MESH:D000109	8973	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic organization and promoter analysis of the human nicotinic acetylcholine receptor alpha6 subunit -LRB- CHNRA6 -RRB- gene : Alu and other elements direct transcriptional repression .
19082523	0	acetylcholine	92,105	CHRFAM7A	127,135	acetylcholine	CHRFAM7A	MESH:D000109	89832	Chemical	Gene	transcript|compound|START_ENTITY decreases|nmod|transcript nicotine|dep|decreases nicotine|appos|END_ENTITY	Differentiating nicotine - versus schizophrenia-associated decreases of the alpha7 nicotinic acetylcholine receptor transcript , CHRFAM7A , in peripheral blood lymphocytes .
19631623	0	acetylcholine	87,100	CHRFAM7A	107,115	acetylcholine	CHRFAM7A	MESH:D000109	89832	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A 2-base pair deletion polymorphism in the partial duplication of the alpha7 nicotinic acetylcholine gene -LRB- CHRFAM7A -RRB- on chromosome 15q14 is associated with schizophrenia .
16874522	0	acetylcholine	58,71	CHRM1	146,151	acetylcholine	CHRM1	MESH:D000109	1128	Chemical	Gene	subunit|amod|START_ENTITY subunit|appos|END_ENTITY	Gene-based analysis suggests association of the nicotinic acetylcholine receptor beta1 subunit -LRB- CHRNB1 -RRB- and M1 muscarinic acetylcholine receptor -LRB- CHRM1 -RRB- with vulnerability for nicotine_dependence .
19404243	0	acetylcholine	24,37	CHRM1	48,53	acetylcholine	CHRM1	MESH:D000109	1128	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Altered M -LRB- 1 -RRB- muscarinic acetylcholine receptor -LRB- CHRM1 -RRB- - Galpha -LRB- q/11 -RRB- coupling in a schizophrenia endophenotype .
15229186	0	acetylcholine	79,92	CHRM2	106,111	acetylcholine	CHRM2	MESH:D000109	1129	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Evidence of common and specific genetic effects : association of the muscarinic acetylcholine receptor M2 -LRB- CHRM2 -RRB- gene with alcohol_dependence and major depressive_syndrome .
16501017	0	acetylcholine	62,75	CHRM2	89,94	acetylcholine	CHRM2	MESH:D000109	1129	Chemical	Gene	M2|amod|START_ENTITY M2|appos|END_ENTITY	Heart rate recovery after maximal exercise is associated with acetylcholine receptor M2 -LRB- CHRM2 -RRB- gene polymorphism .
19181679	0	acetylcholine	84,97	CHRM2	111,116	acetylcholine	CHRM2	MESH:D000109	1129	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Depression Case Control -LRB- DeCC -RRB- Study fails to support involvement of the muscarinic acetylcholine receptor M2 -LRB- CHRM2 -RRB- gene in recurrent major_depressive_disorder .
7910962	0	acetylcholine	28,41	CHRNA	71,76	acetylcholine	CHRNA	MESH:D000109	1134	Chemical	Gene	START_ENTITY|dobj|gene gene|appos|END_ENTITY	Involvement of human muscle acetylcholine receptor alpha-subunit gene -LRB- CHRNA -RRB- in susceptibility to myasthenia_gravis .
8738961	0	acetylcholine	13,26	CHRNA1	56,62	acetylcholine	CHRNA1	MESH:D000109	1134	Chemical	Gene	START_ENTITY|dobj|association association|appos|END_ENTITY	Human muscle acetylcholine receptor alpha-subunit gene -LRB- CHRNA1 -RRB- association with autoimmune_myasthenia_gravis in black , mixed-ancestry and Caucasian subjects .
15996750	0	acetylcholine	67,80	CHRNA2	111,117	acetylcholine	CHRNA2	MESH:D000109	1135	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	No association between common variations in the neuronal nicotinic acetylcholine receptor alpha2 subunit gene -LRB- CHRNA2 -RRB- and bipolar_I disorder .
25847220	0	acetylcholine	100,113	CHRNA2	12,18	acetylcholine	CHRNA2	MESH:D000109	1135	Chemical	Gene	receptor|compound|START_ENTITY role|nmod|receptor Mutation|dep|role Mutation|nmod|END_ENTITY	Mutation of CHRNA2 in a family with benign_familial_infantile_seizures : Potential role of nicotinic acetylcholine receptor in various phenotypes of epilepsy .
15026168	0	acetylcholine	98,111	CHRNA4	51,57	acetylcholine	CHRNA4	MESH:D000109	1137	Chemical	Gene	genes|compound|START_ENTITY neuronal|dobj|genes neuronal|nsubj|studies studies|nmod|alpha_4 alpha_4|appos|END_ENTITY	Candidate gene association studies of the alpha_4 -LRB- CHRNA4 -RRB- and beta_2 -LRB- CHRNB2 -RRB- neuronal nicotinic acetylcholine receptor subunit genes in Alzheimer 's _ disease .
15790597	0	acetylcholine	57,70	CHRNA4	101,107	acetylcholine	CHRNA4	MESH:D000109	1137	Chemical	Gene	association|nmod|START_ENTITY receptor|nsubj|association receptor|dobj|gene gene|appos|END_ENTITY	Ethnic - and gender-specific association of the nicotinic acetylcholine receptor alpha4 subunit gene -LRB- CHRNA4 -RRB- with nicotine_dependence .
15902904	0	acetylcholine	42,55	CHRNA4	87,93	acetylcholine	CHRNA4	MESH:D000109	1137	Chemical	Gene	receptor|compound|START_ENTITY polymorphisms|nmod|receptor Association|nmod|polymorphisms Association|dep|gene gene|appos|END_ENTITY	Association of polymorphisms in nicotinic acetylcholine receptor alpha 4 subunit gene -LRB- CHRNA4 -RRB- , mu-opioid receptor gene -LRB- OPRM1 -RRB- , and ethanol-metabolizing enzyme genes with alcoholism in Korean patients .
16332175	0	acetylcholine	74,87	CHRNA4	21,27	acetylcholine	CHRNA4	MESH:D000109	1137	Chemical	Gene	receptor|compound|START_ENTITY subunit|nmod|receptor encoding|dobj|subunit gene|acl|encoding gene|compound|END_ENTITY	Polymorphisms of the CHRNA4 gene encoding the alpha4 subunit of nicotinic acetylcholine receptor as related to the oxidative DNA damage and the level of apoptotic proteins in lymphocytes of the patients with Alzheimer 's _ disease .
17504247	0	acetylcholine	35,48	CHRNA4	79,85	acetylcholine	CHRNA4	MESH:D000109	1137	Chemical	Gene	receptor|compound|START_ENTITY study|nmod|receptor Association|dep|study Association|dep|gene gene|appos|END_ENTITY	Association study of the nicotinic acetylcholine receptor alpha4 subunit gene , CHRNA4 , in attention-deficit_hyperactivity_disorder .
18762859	0	acetylcholine	96,109	CHRNA4	126,132	acetylcholine	CHRNA4	MESH:D000109	1137	Chemical	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Genetic association analysis of tagging SNPs in alpha4 and beta2 subunits of neuronal nicotinic acetylcholine receptor genes -LRB- CHRNA4 and CHRNB2 -RRB- with schizophrenia in the Japanese population .
19058950	0	acetylcholine	34,47	CHRNA4	62,68	acetylcholine	CHRNA4	MESH:D000109	1137	Chemical	Gene	gene|amod|START_ENTITY mutation|nmod|gene END_ENTITY|nsubj|mutation	A novel mutation of the nicotinic acetylcholine receptor gene CHRNA4 in sporadic_nocturnal_frontal_lobe_epilepsy .
21432576	0	acetylcholine	38,51	CHRNA4	73,79	acetylcholine	CHRNA4	MESH:D000109	1137	Chemical	Gene	subunit|amod|START_ENTITY subunit|appos|END_ENTITY	Polymorphisms in the neural nicotinic acetylcholine receptor a4 subunit -LRB- CHRNA4 -RRB- are associated with ADHD in a genetic isolate .
22947540	0	acetylcholine	53,66	CHRNA4	81,87	acetylcholine	CHRNA4	MESH:D000109	1137	Chemical	Gene	interact|amod|START_ENTITY interact|compound|END_ENTITY	The dopamine_D2_receptor gene DRD2 and the nicotinic acetylcholine receptor gene CHRNA4 interact on striatal gray matter volume : evidence from a genetic imaging study .
23037950	0	acetylcholine	34,47	CHRNA4	63,69	acetylcholine	CHRNA4	MESH:D000109	1137	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Possible association of nicotinic acetylcholine receptor gene -LRB- CHRNA4 and CHRNB2 -RRB- polymorphisms with nicotine_dependence in Japanese males : an exploratory study .
24385388	0	acetylcholine	131,144	CHRNA4	56,62	acetylcholine	CHRNA4	MESH:D000109	1137	Chemical	Gene	receptors|compound|START_ENTITY expression|nmod|receptors affect|dobj|expression variants|xcomp|affect variants|nsubj|subunit subunit|appos|END_ENTITY	Rare human nicotinic acetylcholine receptor a4 subunit -LRB- CHRNA4 -RRB- variants affect expression and function of high-affinity nicotinic acetylcholine receptors .
24385388	0	acetylcholine	21,34	CHRNA4	56,62	acetylcholine	CHRNA4	MESH:D000109	1137	Chemical	Gene	subunit|compound|START_ENTITY subunit|appos|END_ENTITY	Rare human nicotinic acetylcholine receptor a4 subunit -LRB- CHRNA4 -RRB- variants affect expression and function of high-affinity nicotinic acetylcholine receptors .
25282705	0	acetylcholine	34,47	CHRNA4	62,68	acetylcholine	CHRNA4	MESH:D000109	1137	Chemical	Gene	gene|amod|START_ENTITY mutation|nmod|gene END_ENTITY|nsubj|mutation	A novel mutation of the nicotinic acetylcholine receptor gene CHRNA4 in a Chinese patient with non-familial_nocturnal_frontal_lobe_epilepsy .
25639542	0	acetylcholine	110,123	CHRNA4	134,140	acetylcholine	CHRNA4	MESH:D000109	1137	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Individual response speed is modulated by variants of the gene encoding the alpha 4 sub-unit of the nicotinic acetylcholine receptor -LRB- CHRNA4 -RRB- .
7607646	0	acetylcholine	79,92	CHRNA4	124,130	acetylcholine	CHRNA4	MESH:D000109	1137	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Detection of a CfoI polymorphism within exon 5 of the human neuronal nicotinic acetylcholine receptor alpha 4 subunit gene -LRB- CHRNA4 -RRB- .
9216991	0	acetylcholine	59,72	CHRNA4	83,89	acetylcholine	CHRNA4	MESH:D000109	1137	Chemical	Gene	cosegregates|amod|START_ENTITY cosegregates|appos|END_ENTITY	A nonsense mutation in the alpha4 subunit of the nicotinic acetylcholine receptor -LRB- CHRNA4 -RRB- cosegregates with 20q-linked benign_neonatal_familial_convulsions -LRB- EBNI -RRB- Benign_Familial_Neonatal_Convulsions -LRB- BFNC -RRB- is an epileptic_disorder with an autosomal dominant mode of transmission .
11424985	0	acetylcholine	98,111	CHRNA7	135,141	acetylcholine	CHRNA7	MESH:D000109	1139	Chemical	Gene	gene|amod|START_ENTITY locus|nmod|gene disequilibrium|dobj|locus disequilibrium|dep|END_ENTITY	Linkage disequilibrium for schizophrenia at the chromosome 15q13-14 locus of the alpha7-nicotinic acetylcholine receptor subunit gene -LRB- CHRNA7 -RRB- .
11829490	0	acetylcholine	77,90	CHRNA7	106,112	acetylcholine	CHRNA7	MESH:D000109	1139	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A 3-Mb map of a large Segmental duplication overlapping the alpha7-nicotinic acetylcholine receptor gene -LRB- CHRNA7 -RRB- at human 15q13-q14 .
19181484	0	acetylcholine	73,86	CHRNA7	110,116	acetylcholine	CHRNA7	MESH:D000109	1139	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of the 5 ' - upstream regulatory region of the alpha7 nicotinic acetylcholine receptor subunit gene -LRB- CHRNA7 -RRB- with schizophrenia .
27061851	0	acetylcholine	3,16	CHRNA7	152,158	acetylcholine	CHRNA7	MESH:D000109	11441(Tax:10090)	Chemical	Gene	modulator|amod|START_ENTITY rescues|nsubj|modulator rescues|advcl|encompassing encompassing|dobj|END_ENTITY	An acetylcholine alpha7 positive allosteric modulator rescues a schizophrenia-associated brain endophenotype in the 15q13 .3 microdeletion , encompassing CHRNA7 .
16874522	0	acetylcholine	58,71	CHRNB1	96,102	acetylcholine	CHRNB1	MESH:D000109	1140	Chemical	Gene	subunit|amod|START_ENTITY subunit|appos|END_ENTITY	Gene-based analysis suggests association of the nicotinic acetylcholine receptor beta1 subunit -LRB- CHRNB1 -RRB- and M1 muscarinic acetylcholine receptor -LRB- CHRM1 -RRB- with vulnerability for nicotine_dependence .
8508682	0	acetylcholine	55,68	CHRNB1	84,90	acetylcholine	CHRNB1	MESH:D000109	101121614	Chemical	Gene	START_ENTITY|dobj|gene gene|appos|END_ENTITY	Assignment of the beta subunit of the muscle nicotinic acetylcholine receptor gene -LRB- CHRNB1 -RRB- to sheep chromosome 11 .
11054772	0	acetylcholine	74,87	CHRNB2	112,118	acetylcholine	CHRNB2	MESH:D000109	1141	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Haplotypes of four novel single nucleotide polymorphisms in the nicotinic acetylcholine receptor beta2-subunit -LRB- CHRNB2 -RRB- gene show no association with smoking initiation or nicotine_dependence .
11104662	0	acetylcholine	21,34	CHRNB2	0,6	acetylcholine	CHRNB2	MESH:D000109	495135(Tax:8355)	Chemical	Gene	subunit|amod|START_ENTITY subunit|nsubj|END_ENTITY	CHRNB2 is the second acetylcholine receptor subunit associated with autosomal_dominant_nocturnal_frontal_lobe_epilepsy .
11906688	0	acetylcholine	99,112	CHRNB2	128,134	acetylcholine	CHRNB2	MESH:D000109	1141	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic and functional analysis of single nucleotide polymorphisms in the beta2-neuronal nicotinic acetylcholine receptor gene -LRB- CHRNB2 -RRB- .
11952766	0	acetylcholine	33,46	CHRNB2	76,82	acetylcholine	CHRNB2	MESH:D000109	1141	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mutational analysis of nicotinic acetylcholine receptor beta2 subunit gene -LRB- CHRNB2 -RRB- in a representative cohort of Italian probands affected by autosomal_dominant_nocturnal_frontal_lobe_epilepsy .
15026168	0	acetylcholine	98,111	CHRNB2	71,77	acetylcholine	CHRNB2	MESH:D000109	1141	Chemical	Gene	genes|compound|START_ENTITY neuronal|dobj|genes neuronal|nsubj|studies studies|nmod|alpha_4 alpha_4|appos|END_ENTITY	Candidate gene association studies of the alpha_4 -LRB- CHRNA4 -RRB- and beta_2 -LRB- CHRNB2 -RRB- neuronal nicotinic acetylcholine receptor subunit genes in Alzheimer 's _ disease .
18534914	0	acetylcholine	142,155	CHRNB2	94,100	acetylcholine	CHRNB2	MESH:D000109	1141	Chemical	Gene	receptor|compound|START_ENTITY I312M|nmod|receptor I312M|compound|END_ENTITY	Autosomal_dominant_nocturnal_frontal_lobe_epilepsy and mild memory_impairment associated with CHRNB2 mutation I312M in the neuronal nicotinic acetylcholine receptor .
19755656	0	acetylcholine	10,23	CHRNB2	48,54	acetylcholine	CHRNB2	MESH:D000109	1141	Chemical	Gene	beta2|amod|START_ENTITY subunit|nsubj|beta2 subunit|xcomp|gene gene|dep|END_ENTITY	Nicotinic acetylcholine receptor beta2 subunit -LRB- CHRNB2 -RRB- gene and short-term ability to quit smoking in response to nicotine patch .
14735155	0	acetylcholine	65,78	CHRND	89,94	acetylcholine	CHRND	MESH:D000109	1144	Chemical	Gene	START_ENTITY|dobj|receptor receptor|appos|END_ENTITY	Association of the gene encoding the delta-subunit of the muscle acetylcholine receptor -LRB- CHRND -RRB- with acquired autoimmune_myasthenia_gravis .
16916845	0	acetylcholine	89,102	CHRND	0,5	acetylcholine	CHRND	MESH:D000109	1144	Chemical	Gene	receptor|amod|START_ENTITY co-clustering|nmod|receptor impairing|dobj|co-clustering causes|advcl|impairing causes|nsubj|mutation mutation|compound|END_ENTITY	CHRND mutation causes a congenital_myasthenic_syndrome by impairing co-clustering of the acetylcholine receptor with rapsyn .
16826531	0	acetylcholine	42,55	CHRNG	66,71	acetylcholine	CHRNG	MESH:D000109	1146	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Mutations in the embryonal subunit of the acetylcholine receptor -LRB- CHRNG -RRB- cause lethal and Escobar variants of multiple_pterygium_syndrome .
15932886	0	acetylcholine	31,44	Ca2	0,3	acetylcholine	Ca2	MESH:D000109	54231(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY permeability|nmod|receptors permeability|amod|END_ENTITY	Ca2 + permeability of nicotinic acetylcholine receptors in rat hippocampal CA1 interneurones .
17510177	0	acetylcholine	76,89	Ca2	10,13	acetylcholine	Ca2	MESH:D000109	54231(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY activation|nmod|receptors due|nmod|activation neurons|amod|due signalling|dobj|neurons +|xcomp|signalling +|nsubj|END_ENTITY	Dendritic Ca2 + signalling due to activation of alpha 7-containing nicotinic acetylcholine receptors in rat hippocampal neurons .
2043245	0	acetylcholine	42,55	Ca2	106,109	acetylcholine	Ca2	MESH:D000109	280740(Tax:9913)	Chemical	Gene	START_ENTITY|nmod|concentration concentration|nmod|+ +|compound|END_ENTITY	Dose-dependent effects of angiotensin II , acetylcholine and vasopressin on the cytosolic concentration of Ca2 + in suspension primary cultures of zona fasciculata/reticularis cells from bovine adrenal cortex .
2335224	0	acetylcholine	40,53	Ca2	12,15	acetylcholine	Ca2	MESH:D000109	12349(Tax:10090)	Chemical	Gene	infusion|compound|START_ENTITY evoked|nmod|infusion oscillations|acl|evoked oscillations|amod|END_ENTITY	Cytoplasmic Ca2 + oscillations evoked by acetylcholine or intracellular infusion of inositol_trisphosphate or Ca2 + can be inhibited by internal Ca2 + .
2335224	0	acetylcholine	40,53	Ca2	143,146	acetylcholine	Ca2	MESH:D000109	12349(Tax:10090)	Chemical	Gene	infusion|compound|START_ENTITY evoked|nmod|infusion oscillations|acl|evoked inhibited|nsubjpass|oscillations inhibited|nmod|+ +|amod|END_ENTITY	Cytoplasmic Ca2 + oscillations evoked by acetylcholine or intracellular infusion of inositol_trisphosphate or Ca2 + can be inhibited by internal Ca2 + .
2548265	0	acetylcholine	75,88	Ca2	0,3	acetylcholine	Ca2	MESH:D000109	477928(Tax:9615)	Chemical	Gene	induced|nmod|START_ENTITY flow|acl|induced rise|nmod|flow sustain|dobj|rise sustain|nsubj|antagonists antagonists|compound|END_ENTITY	Ca2 + antagonists and db-cAMP sustain a rise in renal blood flow induced by acetylcholine in indomethacin-treated dogs .
3417107	0	acetylcholine	124,137	Ca2	10,13	acetylcholine	Ca2	MESH:D000109	100719293	Chemical	Gene	showing|advcl|START_ENTITY cells|acl|showing desensitization|nmod|cells +|nmod|desensitization +|nsubj|Effect Effect|nmod|END_ENTITY	Effect of Ca2 + deprivation on short-term desensitization of isolated smooth muscle cells showing an all-or-none response to acetylcholine .
3625199	0	acetylcholine	12,25	Ca2	37,40	acetylcholine	Ca2	MESH:D000109	100719293	Chemical	Gene	release|amod|START_ENTITY release|nmod|Ca2 Ca2|compound|END_ENTITY	Relation of acetylcholine release to Ca2 + uptake and intraterminal Ca2 + concentration in guinea-pig cortex synaptosomes .
3625199	0	acetylcholine	12,25	Ca2	67,70	acetylcholine	Ca2	MESH:D000109	100719293	Chemical	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	Relation of acetylcholine release to Ca2 + uptake and intraterminal Ca2 + concentration in guinea-pig cortex synaptosomes .
6296872	0	acetylcholine	29,42	Ca2	116,119	acetylcholine	Ca2	MESH:D000109	760	Chemical	Gene	release|amod|START_ENTITY potentiation|nmod|release develops|nsubj|potentiation develops|nmod|stimulation stimulation|nmod|+ +|amod|END_ENTITY	Post-tetanic potentiation of acetylcholine release at the frog neuromuscular junction develops after stimulation in Ca2 + - free solutions .
6697191	0	acetylcholine	137,150	Ca2	96,99	acetylcholine	Ca2	MESH:D000109	12349(Tax:10090)	Chemical	Gene	release|nmod|START_ENTITY release|amod|END_ENTITY	Depolarization of mouse forebrain minces with veratridine and high K + : failure to stimulate the Ca2 + independent , spontaneous release of acetylcholine from the cytoplasm due to hydrolysis of the acetylcholine stored there .
6697191	0	acetylcholine	195,208	Ca2	96,99	acetylcholine	Ca2	MESH:D000109	12349(Tax:10090)	Chemical	Gene	hydrolysis|nmod|START_ENTITY due|nmod|hydrolysis cytoplasm|amod|due stimulate|nmod|cytoplasm stimulate|dobj|release release|amod|END_ENTITY	Depolarization of mouse forebrain minces with veratridine and high K + : failure to stimulate the Ca2 + independent , spontaneous release of acetylcholine from the cytoplasm due to hydrolysis of the acetylcholine stored there .
6704592	0	acetylcholine	53,66	Ca2	89,92	acetylcholine	Ca2	MESH:D000109	54231(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nmod|+ +|compound|END_ENTITY	Contractions of rat uterine smooth muscle induced by acetylcholine and angiotensin_II in Ca2 + - free medium .
8586963	0	acetylcholine	18,31	Ca2	0,3	acetylcholine	Ca2	MESH:D000109	396257(Tax:9031)	Chemical	Gene	+|nmod|START_ENTITY +|nsubj|END_ENTITY	Ca2 + responses to acetylcholine and adenosine_triphosphate in the otocyst of chick embryo .
8596722	0	acetylcholine	120,133	Ca2	84,87	acetylcholine	Ca2	MESH:D000109	760	Chemical	Gene	current|nmod|START_ENTITY dependent|nmod|current dependent|dep|modulation modulation|nmod|+ +|amod|END_ENTITY	Evidence that Ca/calmodulin-dependent protein kinase mediates the modulation of the Ca2 + - dependent K + current , IAHP , by acetylcholine , but not by glutamate , in hippocampal neurons .
8760362	0	acetylcholine	94,107	Ca2	72,75	acetylcholine	Ca2	MESH:D000109	12349(Tax:10090)	Chemical	Gene	+|nmod|START_ENTITY +|nsubj|Amplification Amplification|nmod|increase increase|nmod|END_ENTITY	Amplification of the thapsigargin-evoked increase in the cytosolic free Ca2 + concentration by acetylcholine in acutely isolated mouse submandibular acinar cells .
3490625	0	acetylcholine	49,62	Calcitonin_gene-related_peptide	0,31	acetylcholine	Calcitonin gene-related peptide	MESH:D000109	796	Chemical	Gene	synthesis|compound|START_ENTITY regulates|dobj|synthesis regulates|nsubj|END_ENTITY	Calcitonin_gene-related_peptide regulates muscle acetylcholine receptor synthesis .
26567709	0	acetylcholine	99,112	Catestatin	0,10	acetylcholine	Catestatin	MESH:D000109	1113	Chemical	Gene	receptor|compound|START_ENTITY reperfusion|dep|receptor attenuates|dep|reperfusion attenuates|nsubj|END_ENTITY	Catestatin attenuates endoplasmic reticulum induced cell apoptosis by activation type 2 muscarinic acetylcholine receptor in cardiac_ischemia / reperfusion .
1207876	0	acetylcholine	76,89	Choline_acetyltransferase	0,25	acetylcholine	Choline acetyltransferase	MESH:D000109	290567(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Choline_acetyltransferase activity and mass fragmentographic measurement of acetylcholine in specific nuclei and tracts of rat brain .
18506429	7	acetylcholine	1240,1253	Chrna1	1264,1270	acetylcholine	Atp2a2	MESH:D000109	11938(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	The specific cDNA templates of genes coding for subunits of the mouse muscle acetylcholine receptor -LRB- Chrna1 , Chrnb1 , Chrnd -RRB- and the genes coding for myogenin -LRB- Myog -RRB- , muscle creatine kinase -LRB- Ckmm -RRB- , and ATPase -LRB- Atp2a2 -RRB- were amplified on a biochip by RT-PCR directly from freshly isolated mRNA .
9681452	0	acetylcholine	100,113	Corticotropin-releasing_factor	0,30	acetylcholine	Corticotropin-releasing factor	MESH:D000109	81648(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY stimulates|dobj|release stimulates|nsubj|centrally centrally|compound|END_ENTITY	Corticotropin-releasing_factor administered centrally , but not peripherally , stimulates hippocampal acetylcholine release .
7861114	0	acetylcholine	43,56	D_alpha_2	74,83	acetylcholine	D alpha 2	MESH:D000109	42919(Tax:7227)	Chemical	Gene	receptor|compound|START_ENTITY Expression|nmod|receptor subunit|nsubj|Expression subunit|dobj|END_ENTITY	Expression of the ligand-binding nicotinic acetylcholine receptor subunit D_alpha_2 in the Drosophila central nervous system .
11973307	0	acetylcholine	25,38	Dalpha5	63,70	acetylcholine	Dalpha5	MESH:D000109	34826(Tax:7227)	Chemical	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Novel putative nicotinic acetylcholine receptor subunit genes , Dalpha5 , Dalpha6 and Dalpha7 , in Drosophila_melanogaster identify a new and highly conserved target of adenosine_deaminase_acting_on_RNA-mediated A-to-I pre-mRNA editing .
15228604	0	acetylcholine	60,73	Dalpha6	30,37	acetylcholine	Dalpha6	MESH:D000109	34304(Tax:7227)	Chemical	Gene	subunits|amod|START_ENTITY subunits|amod|END_ENTITY	Molecular characterization of Dalpha6 and Dalpha7 nicotinic acetylcholine receptor subunits from Drosophila : formation of a high-affinity alpha-bungarotoxin binding site revealed by expression of subunit chimeras .
25676809	0	acetylcholine	53,66	ERK	84,87	acetylcholine	ERK	MESH:D000109	5594	Chemical	Gene	receptor|compound|START_ENTITY receptor|nmod|END_ENTITY	Galanin up-regulates the expression of M1 muscarinic acetylcholine receptor via the ERK signaling pathway in primary cultured prefrontal cortical neurons .
11292831	0	acetylcholine	58,71	ERK1/2	103,109	acetylcholine	ERK1/2	MESH:D000109	50689;116590	Chemical	Gene	receptors|compound|START_ENTITY receptors|nmod|activation activation|nmod|END_ENTITY	A CalDAG-GEFI/Rap1/B-Raf cassette couples M -LRB- 1 -RRB- muscarinic acetylcholine receptors to the activation of ERK1/2 .
7589796	0	acetylcholine	36,49	ErbB2	121,126	acetylcholine	ErbB2	MESH:D000109	2064	Chemical	Gene	protein|amod|START_ENTITY expression|nmod|protein expression|appos|END_ENTITY	Synapse-associated expression of an acetylcholine receptor-inducing protein , ARIA/heregulin , and its putative receptors , ErbB2 and ErbB3 , in developing mammalian muscle .
9570817	0	acetylcholine	36,49	Fos	76,79	acetylcholine	Fos	MESH:D000109	314322(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|induction induction|nmod|END_ENTITY	Nerve gas-induced seizures : role of acetylcholine in the rapid induction of Fos and glial_fibrillary_acidic_protein in piriform cortex .
9349981	0	acetylcholine	8,21	GRP	53,56	acetylcholine	GRP	MESH:D000109	171101(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of acetylcholine and gastrin-releasing_peptide -LRB- GRP -RRB- in gastrin secretion .
11856737	0	acetylcholine	71,84	G_protein-coupled_receptor_kinase_6	11,46	acetylcholine	G protein-coupled receptor kinase 6	MESH:D000109	2870	Chemical	Gene	phosphorylation|amod|START_ENTITY END_ENTITY|dobj|phosphorylation	Endogenous G_protein-coupled_receptor_kinase_6 Regulates M3 muscarinic acetylcholine receptor phosphorylation and desensitization in human SH-SY5Y neuroblastoma cells .
1719453	0	acetylcholine	19,32	Galanin	0,7	acetylcholine	Galanin	MESH:D000109	29141(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Galanin stimulates acetylcholine release in the rat striatum .
7688904	0	acetylcholine	28,41	Galanin	0,7	acetylcholine	Galanin	MESH:D000109	29141(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY unrelated|nsubj|release stimulates|xcomp|unrelated stimulates|nsubj|END_ENTITY	Galanin stimulates striatal acetylcholine release via a mechanism unrelated to cholinergic receptor stimulation .
7706286	0	acetylcholine	91,104	Hm1	105,108	acetylcholine	Hm1	MESH:D000109	1128	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Activating and inactivating mutations in N - and C-terminal i3 loop junctions of muscarinic acetylcholine Hm1 receptors .
11712854	0	acetylcholine	101,114	IL-2	144,148	acetylcholine	IL-2	MESH:D000109	16183(Tax:10090)	Chemical	Gene	IFN-gamma|amod|START_ENTITY IFN-gamma|appos|production production|amod|END_ENTITY	HLA-DQ6 transgenic_mice resistance to experimental autoimmune_myasthenia_gravis is linked to reduced acetylcholine receptor-specific IFN-gamma , IL-2 and IL-10 production .
15109075	0	acetylcholine	10,23	IL-2	36,40	acetylcholine	IL-2	MESH:D000109	116562(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|production production|compound|END_ENTITY	Effect of acetylcholine on in vitro IL-2 production and NK cell cytotoxicity of rats .
15516795	0	acetylcholine	45,58	IL-6	8,12	acetylcholine	IL-6	MESH:D000109	16193(Tax:10090)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of IL-6 and IL-1beta in reactivation by acetylcholine of latently infecting pseudorabies_virus .
3380358	0	acetylcholine	55,68	Insulin-like_growth_factor_1	0,28	acetylcholine	Insulin-like growth factor 1	MESH:D000109	24482(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Insulin-like_growth_factor_1 stimulates the release of acetylcholine from rat cortical slices .
1884236	0	acetylcholine	29,42	Interleukin-1_beta	0,18	acetylcholine	Interleukin-1 beta	MESH:D000109	24494(Tax:10116)	Chemical	Gene	decreases|dobj|START_ENTITY decreases|nsubj|END_ENTITY	Interleukin-1_beta decreases acetylcholine measured by microdialysis in the hippocampus of freely moving rats .
2788477	0	acetylcholine	28,41	Interleukin-1_beta	0,18	acetylcholine	Interleukin-1 beta	MESH:D000109	3553	Chemical	Gene	synthesis|amod|START_ENTITY inhibits|dobj|synthesis inhibits|nsubj|END_ENTITY	Interleukin-1_beta inhibits acetylcholine synthesis in the pituitary corticotropic cell line AtT20 .
24558448	0	acetylcholine	102,115	M1	69,71	acetylcholine	M1	MESH:D000109	1128	Chemical	Gene	receptors|compound|START_ENTITY subtypes|nmod|receptors subtypes|compound|END_ENTITY	Long-term activation upon brief exposure to xanomleline is unique to M1 and M4 subtypes of muscarinic acetylcholine receptors .
25882246	0	acetylcholine	55,68	M1	41,43	acetylcholine	M1	MESH:D000109	1128	Chemical	Gene	receptors|compound|START_ENTITY receptors|nummod|END_ENTITY	Classical and atypical agonists activate M1 muscarinic acetylcholine receptors through common mechanisms .
25882246	0	acetylcholine	55,68	M1	41,43	acetylcholine	M1	MESH:D000109	1128	Chemical	Gene	receptors|compound|START_ENTITY receptors|nummod|END_ENTITY	Classical and atypical agonists activate M1 muscarinic acetylcholine receptors through common mechanisms .
26428869	0	acetylcholine	107,120	M1_and_M4	86,95	acetylcholine	M1 and M4	MESH:D000109	25111(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY END_ENTITY|dep|receptors	Discovery of dihydroquinazolinone derivatives as potent , selective , and CNS-penetrant M1_and_M4 muscarinic acetylcholine receptors agonists .
1756238	0	acetylcholine	23,36	NGF	0,3	acetylcholine	NGF	MESH:D000109	310738(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY increases|dobj|release increases|nsubj|END_ENTITY	NGF increases cortical acetylcholine release in rats with lesions of the nucleus basalis .
7965809	0	acetylcholine	67,80	NS-3	10,14	acetylcholine	NS-3	MESH:D000109	25263(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY Effect|nmod|release Effect|nmod|END_ENTITY	Effect of NS-3 , a thyrotropin-releasing_hormone analog , on in vivo acetylcholine release in rat brain : regional differences and its sites of action .
11331367	0	acetylcholine	46,59	Nerve_growth_factor	0,19	acetylcholine	Nerve growth factor	MESH:D000109	4803	Chemical	Gene	release|amod|START_ENTITY induces|dobj|release induces|nsubj|END_ENTITY	Nerve_growth_factor rapidly induces prolonged acetylcholine release from cultured basal forebrain neurons : differentiation between neuromodulatory and neurotrophic_influences .
8041485	0	acetylcholine	44,57	Nerve_growth_factor	0,19	acetylcholine	Nerve growth factor	MESH:D000109	310738(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY increases|dobj|levels increases|nsubj|END_ENTITY	Nerve_growth_factor increases extracellular acetylcholine levels in the parietal cortex and hippocampus of aged rats and restores object recognition .
1279982	0	acetylcholine	35,48	Neurokinin3_receptor	0,20	acetylcholine	Neurokinin3 receptor	MESH:D000109	100135627(Tax:10141)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Neurokinin3_receptor regulation of acetylcholine release from myenteric plexus .
2018533	0	acetylcholine	119,132	Phospholipase_D	0,15	acetylcholine	Phospholipase D	MESH:D000109	2822	Chemical	Gene	START_ENTITY|nsubj|activity activity|amod|END_ENTITY	Phospholipase_D activity and phosphatidylethanol formation in stimulated HeLa cells expressing the human m1 muscarinic acetylcholine receptor gene .
12810794	0	acetylcholine	26,39	Pick	62,66	acetylcholine	Pick	MESH:D000109	9463	Chemical	Gene	receptors|compound|START_ENTITY receptors|nmod|END_ENTITY	Alterations of muscarinic acetylcholine receptors in atypical Pick 's _ disease without Pick bodies .
2469679	0	acetylcholine	20,33	RAPsyn	63,69	acetylcholine	RAPsyn	MESH:D000109	5913	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	The mammalian 43-kD acetylcholine receptor-associated protein -LRB- RAPsyn -RRB- is expressed in some nonmuscle cells .
3170600	0	acetylcholine	49,62	RAPsyn	92,98	acetylcholine	RAPsyn	MESH:D000109	19400(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|protein protein|appos|END_ENTITY	Identification of the mouse muscle 43,000-dalton acetylcholine receptor-associated protein -LRB- RAPsyn -RRB- by cDNA cloning .
12070151	0	acetylcholine	40,53	Rac1	18,22	acetylcholine	Rac1	MESH:D000109	100756792	Chemical	Gene	receptors|compound|START_ENTITY END_ENTITY|nmod|receptors	The activation of Rac1 by M3 muscarinic acetylcholine receptors involves the translocation of Rac1 and IQGAP1 to cell junctions and changes in the composition of protein complexes containing Rac1 , IQGAP1 , and actin .
12070151	0	acetylcholine	40,53	Rac1	191,195	acetylcholine	Rac1	MESH:D000109	100756792	Chemical	Gene	receptors|compound|START_ENTITY Rac1|nmod|receptors activation|nmod|Rac1 involves|nsubj|activation involves|advcl|containing containing|dobj|END_ENTITY	The activation of Rac1 by M3 muscarinic acetylcholine receptors involves the translocation of Rac1 and IQGAP1 to cell junctions and changes in the composition of protein complexes containing Rac1 , IQGAP1 , and actin .
12070151	0	acetylcholine	40,53	Rac1	94,98	acetylcholine	Rac1	MESH:D000109	100756792	Chemical	Gene	receptors|compound|START_ENTITY Rac1|nmod|receptors activation|nmod|Rac1 involves|nsubj|activation involves|dobj|translocation translocation|nmod|END_ENTITY	The activation of Rac1 by M3 muscarinic acetylcholine receptors involves the translocation of Rac1 and IQGAP1 to cell junctions and changes in the composition of protein complexes containing Rac1 , IQGAP1 , and actin .
15102936	0	acetylcholine	49,62	Rac1	9,13	acetylcholine	Rac1	MESH:D000109	5879	Chemical	Gene	inhibition|amod|START_ENTITY changes|dobj|inhibition changes|nsubj|activity activity|amod|END_ENTITY	Elevated Rac1 activity changes the M3 muscarinic acetylcholine receptor-mediated inhibition of proliferation to induction of cell death .
23887096	0	acetylcholine	114,127	Rac1	37,41	acetylcholine	Rac1	MESH:D000109	5879	Chemical	Gene	receptors|compound|START_ENTITY antagonist|nmod|receptors acts|nmod|antagonist acts|nsubj|NSC23766 NSC23766|appos|inhibitor inhibitor|nmod|activation activation|amod|END_ENTITY	NSC23766 , a widely used inhibitor of Rac1 activation , additionally acts as a competitive antagonist at muscarinic acetylcholine receptors .
24697698	0	acetylcholine	14,27	Rac1	58,62	acetylcholine	Rac1	MESH:D000109	5879	Chemical	Gene	dysfunction|amod|START_ENTITY inhibits|nsubj|dysfunction inhibits|dobj|activity activity|amod|END_ENTITY	M3 muscarinic acetylcholine receptor dysfunction inhibits Rac1 activity and disrupts VE-cadherin/b-catenin and actin cytoskeleton interaction .
11278328	0	acetylcholine	112,125	Rapsyn	85,91	acetylcholine	Rapsyn	MESH:D000109	5913	Chemical	Gene	clustering|amod|START_ENTITY requires|nmod|clustering requires|dobj|END_ENTITY	Agrin-induced activation of acetylcholine receptor-bound Src family kinases requires Rapsyn and correlates with acetylcholine receptor clustering .
11278328	0	acetylcholine	28,41	Rapsyn	85,91	acetylcholine	Rapsyn	MESH:D000109	5913	Chemical	Gene	kinases|amod|START_ENTITY activation|nmod|kinases requires|nsubj|activation requires|dobj|END_ENTITY	Agrin-induced activation of acetylcholine receptor-bound Src family kinases requires Rapsyn and correlates with acetylcholine receptor clustering .
12388596	0	acetylcholine	29,42	Rapsyn	0,6	acetylcholine	Rapsyn	MESH:D000109	5913	Chemical	Gene	receptor|compound|START_ENTITY escorts|dobj|receptor escorts|nsubj|END_ENTITY	Rapsyn escorts the nicotinic acetylcholine receptor along the exocytic pathway via association with lipid rafts .
18436384	0	acetylcholine	102,115	Rapsyn	0,6	acetylcholine	Rapsyn	MESH:D000109	19400(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY phosphorylation|nmod|receptor mediate|dobj|phosphorylation carboxyl|ccomp|mediate carboxyl|nsubj|END_ENTITY	Rapsyn carboxyl terminal domains mediate muscle specific kinase-induced phosphorylation of the muscle acetylcholine receptor .
19482062	0	acetylcholine	33,46	Rapsyn	0,6	acetylcholine	Rapsyn	MESH:D000109	19400(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY interacts|nmod|receptor interacts|nsubj|END_ENTITY	Rapsyn interacts with the muscle acetylcholine receptor via alpha-helical domains in the alpha , beta , and epsilon subunit intracellular loops .
7619516	0	acetylcholine	42,55	Rapsyn	0,6	acetylcholine	Rapsyn	MESH:D000109	5913	Chemical	Gene	receptor|amod|START_ENTITY link|nmod|receptor function|nmod|link function|nsubj|END_ENTITY	Rapsyn may function as a link between the acetylcholine receptor and the agrin-binding dystrophin-associated glycoprotein complex .
8954631	0	acetylcholine	255,268	Rapsyn	31,37	acetylcholine	Rapsyn	MESH:D000109	5913	Chemical	Gene	receptor|amod|START_ENTITY clustering|nmod|receptor role|nmod|clustering play|dobj|role suggested|xcomp|play suggested|nsubjpass|Phosphorylation Phosphorylation|compound|END_ENTITY	The Synapse-Associated Protein Rapsyn Regulates Tyrosine Phosphorylation of Proteins Colocalized at Nicotinic Acetylcholine Receptor Clusters Protein tyrosine phosphorylation has been suggested to play an important role in the clustering of the nicotinic acetylcholine receptor -LRB- AChR -RRB- at the developing neuromuscular junction .
9361285	0	acetylcholine	55,68	Rapsyn	0,6	acetylcholine	Rapsyn	MESH:D000109	5913	Chemical	Gene	receptor|amod|START_ENTITY degradation|nmod|receptor slow|dobj|degradation slow|nsubj|END_ENTITY	Rapsyn and agrin slow the metabolic degradation of the acetylcholine receptor .
9592096	0	acetylcholine	25,38	Rapsyn	0,6	acetylcholine	Rapsyn	MESH:D000109	5913	Chemical	Gene	receptors|amod|START_ENTITY neuronal|dobj|receptors neuronal|nsubj|clusters clusters|compound|END_ENTITY	Rapsyn clusters neuronal acetylcholine receptors but is inessential for formation of an interneuronal cholinergic synapse .
26025922	3	acetylcholine	396,409	RyR1	384,388	acetylcholine	Ryr1	MESH:D000109	6261	Chemical	Gene	receptor|amod|START_ENTITY END_ENTITY|nmod|receptor	Here we reveal a role for functional RyR1 during acetylcholine receptor -LRB- AChR -RRB- cluster formation and embryonic synaptic transmission .
8274060	0	acetylcholine	99,112	SIN-1	39,44	acetylcholine	SIN-1	MESH:D000109	79109	Chemical	Gene	-RSB-|amod|START_ENTITY induced|nmod|-RSB- Effects|acl|induced Effects|nmod|END_ENTITY	-LSB- Effects of intracoronary injection of SIN-1 on vasoconstriction of epicardial arteries induced by acetylcholine -RSB- .
17286989	0	acetylcholine	74,87	SLURP-1	28,35	acetylcholine	SLURP-1	MESH:D000109	57152	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Immune system expression of SLURP-1 and SLURP-2 , two endogenous nicotinic acetylcholine receptor ligands .
18764860	0	acetylcholine	40,53	SLURP-1	71,78	acetylcholine	SLURP-1	MESH:D000109	57152	Chemical	Gene	receptor|compound|START_ENTITY Expression|nmod|receptor Expression|amod|END_ENTITY	Expression of the endogenous , nicotinic acetylcholine receptor ligand , SLURP-1 , in human colon_cancer .
19396877	0	acetylcholine	54,67	SLURP-1	14,21	acetylcholine	SLURP-1	MESH:D000109	57277(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|appos|receptor	Expression of SLURP-1 , an endogenous alpha7 nicotinic acetylcholine receptor allosteric ligand , in murine bronchial epithelial cells .
19409425	0	acetylcholine	72,85	SLURP-1	39,46	acetylcholine	SLURP-1	MESH:D000109	57152	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|appos|receptor	Primary sensory neuronal expression of SLURP-1 , an endogenous nicotinic acetylcholine receptor ligand .
20621062	0	acetylcholine	166,179	SLURP-1	114,121	acetylcholine	SLURP-1	MESH:D000109	57277(Tax:10090)	Chemical	Gene	modulator|compound|START_ENTITY peptide-1|appos|modulator peptide-1|appos|END_ENTITY	Down-regulation of secreted lymphocyte antigen-6 / urokinase-type plasminogen activator receptor-related peptide-1 -LRB- SLURP-1 -RRB- , an endogenous allosteric alpha7 nicotinic acetylcholine receptor modulator , in murine and human asthmatic_conditions .
20660165	0	acetylcholine	92,105	SLURP-1	52,59	acetylcholine	SLURP-1	MESH:D000109	57152	Chemical	Gene	receptor|compound|START_ENTITY mediated|nmod|receptor mediated|nsubjpass|Upregulation Upregulation|nmod|expression expression|nmod|END_ENTITY	Upregulation of nuclear factor-kappaB expression by SLURP-1 is mediated by alpha7-nicotinic acetylcholine receptor and involves both ionic events and activation of protein kinases .
20739627	1	acetylcholine	219,232	SLURP-1	179,186	acetylcholine	SLURP-1	MESH:D000109	57152	Chemical	Gene	receptor|compound|START_ENTITY mediated|nmod|receptor mediated|nsubjpass|Focus Focus|nmod|Upregulation Upregulation|nmod|expression expression|nmod|END_ENTITY	Focus on `` Upregulation of nuclear factor-kappaB expression by SLURP-1 is mediated by alpha7-nicotinic acetylcholine receptor and involves both ionic events and activation of protein kinases '' .
23581991	0	acetylcholine	85,98	SLURP-1	21,28	acetylcholine	SLURP-1	MESH:D000109	57152	Chemical	Gene	receptor|compound|START_ENTITY binding|nmod|receptor expression|amod|binding END_ENTITY|dep|expression	Human neuromodulator SLURP-1 : bacterial expression , binding to muscle-type nicotinic acetylcholine receptor , secondary structure , and conformational heterogeneity in solution .
24365495	0	acetylcholine	36,49	SLURP-1	0,7	acetylcholine	SLURP-1	MESH:D000109	57152	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|appos|receptor	SLURP-1 , an endogenous a7 nicotinic acetylcholine receptor allosteric ligand , is expressed in CD205 -LRB- + -RRB- dendritic cells in human tonsils and potentiates lymphocytic cholinergic activity .
15318222	0	acetylcholine	12,25	SNF-6	0,5	acetylcholine	SNF-6	MESH:D000109	191768(Tax:6239)	Chemical	Gene	transporter|amod|START_ENTITY transporter|nsubj|END_ENTITY	SNF-6 is an acetylcholine transporter interacting with the dystrophin complex in Caenorhabditis_elegans .
187417	0	acetylcholine	37,50	Somatostatin	0,12	acetylcholine	Somatostatin	MESH:D000109	100730851	Chemical	Gene	release|nmod|START_ENTITY inhibits|dobj|release inhibits|nsubj|END_ENTITY	Somatostatin inhibits the release of acetylcholine induced electrically in the myenteric plexus .
2569837	0	acetylcholine	24,37	Somatostatin	0,12	acetylcholine	Somatostatin	MESH:D000109	6750	Chemical	Gene	release|amod|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Somatostatin stimulates acetylcholine release in the canine heart .
1381656	0	acetylcholine	66,79	Substance_P	0,11	acetylcholine	Substance P	MESH:D000109	6863	Chemical	Gene	vesicles|amod|START_ENTITY inhibits|nmod|vesicles inhibits|nsubj|END_ENTITY	Substance_P inhibits carbamylcholine-stimulated_22Na + efflux from acetylcholine receptor-enriched Torpedo electroplaque membrane vesicles .
2449625	0	acetylcholine	23,36	Substance_P	0,11	acetylcholine	Substance P	MESH:D000109	6863	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Substance_P , nicotinic acetylcholine receptors and antinociception in the rat .
2467641	0	acetylcholine	23,36	Substance_P	1,12	acetylcholine	Substance P	MESH:D000109	6863	Chemical	Gene	release|amod|START_ENTITY increases|dobj|release increases|nsubj|END_ENTITY	-LSB- Substance_P increases acetylcholine release from vagal nerve terminals -RSB- .
2472601	0	acetylcholine	18,31	Substance_P	0,11	acetylcholine	Substance P	MESH:D000109	6863	Chemical	Gene	augments|nmod|START_ENTITY augments|nsubj|END_ENTITY	Substance_P , like acetylcholine , augments one type of Ca2 + current in isolated smooth muscle cells .
8835640	0	acetylcholine	76,89	TA-0910	10,17	acetylcholine	TA-0910	MESH:D000109	1456445(Tax:273075)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of TA-0910 , a novel thyrotropin-releasing_hormone analog , on in vivo acetylcholine release and turnover in rat brain .
9272630	0	acetylcholine	65,78	Thyrotropin_releasing_hormone	0,29	acetylcholine	Thyrotropin releasing hormone	MESH:D000109	22044(Tax:10090)	Chemical	Gene	abnormalities|nmod|START_ENTITY prevents|dobj|abnormalities prevents|nsubj|END_ENTITY	Thyrotropin_releasing_hormone prevents abnormalities of cortical acetylcholine and monoamines in mice following head_injury .
19021024	0	acetylcholine	10,23	VAChT	37,42	acetylcholine	VAChT	MESH:D000109	60422(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Vesicular acetylcholine transporter -LRB- VAChT -RRB- in the brain of spontaneously hypertensive rats -LRB- SHR -RRB- : effect of treatment with an acetylcholinesterase inhibitor .
24260111	2	acetylcholine	536,549	VAChT	454,459	acetylcholine	VAChT	MESH:D000109	20508(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY consequences|nmod|uptake investigate|dobj|consequences used|advcl|investigate used|nmod|expression expression|nmod|END_ENTITY	Here we used a mouse model -LRB- VAChT_KD -LRB- HOM -RRB- -RRB- with 70 % reduction in the expression of VAChT to investigate the morphological and functional consequences of a decreased acetylcholine uptake and release in neuromuscular synapses .
26655826	2	acetylcholine	372,385	VAChT	359,364	acetylcholine	VAChT	MESH:D000109	42795(Tax:7227)	Chemical	Gene	START_ENTITY|nsubj|loads loads|appos|END_ENTITY	The vesicular_acetylcholine_transporter -LRB- VAChT -RRB- loads acetylcholine into SVs at cholinergic synapses .
7857778	0	acetylcholine	30,43	VAChT	57,62	acetylcholine	VAChT	MESH:D000109	60422(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY Distribution|nmod|transporter Distribution|appos|END_ENTITY	Distribution of the vesicular acetylcholine transporter -LRB- VAChT -RRB- in the central and peripheral nervous systems of the rat .
9034903	0	acetylcholine	10,23	VAChT	37,42	acetylcholine	VAChT	MESH:D000109	60422(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Vesicular acetylcholine transporter -LRB- VAChT -RRB- protein : a novel and unique marker for cholinergic neurons in the central and peripheral nervous systems .
9568566	0	acetylcholine	84,97	VAChT	111,116	acetylcholine	VAChT	MESH:D000109	6572	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Innervation of intestinal arteries by axons with immunoreactivity for the vesicular acetylcholine transporter -LRB- VAChT -RRB- .
9676745	0	acetylcholine	39,52	VAChT	66,71	acetylcholine	VAChT	MESH:D000109	60422(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transport|nmod|transporter transport|appos|END_ENTITY	Fast axonal transport of the vesicular acetylcholine transporter -LRB- VAChT -RRB- in cholinergic neurons in the rat sciatic nerve .
24911952	0	acetylcholine	79,92	VEGF	24,28	acetylcholine	VEGF	MESH:D000109	7422	Chemical	Gene	START_ENTITY|nsubj|involvement involvement|nmod|END_ENTITY	Possible involvement of VEGF signaling system in rescuing effect of endogenous acetylcholine on NMDA-induced long-lasting hippocampal_cell_damage in organotypic hippocampal slice cultures .
3401753	0	acetylcholine	83,96	VIP	143,146	acetylcholine	VIP	MESH:D000109	7432	Chemical	Gene	peptide|amod|START_ENTITY peptide|appos|END_ENTITY	Neuronal and paracrine regulation of adrenal steroidogenesis : interactions between acetylcholine , serotonin and vasoactive intestinal peptide -LRB- VIP -RRB- on corticosteroid production by frog interrenal tissue .
12434396	0	acetylcholine	116,129	ZO-1	93,97	acetylcholine	ZO-1	MESH:D000109	407102(Tax:9913)	Chemical	Gene	receptors|compound|START_ENTITY END_ENTITY|nmod|receptors	Nicotine and cotinine modulate cerebral microvascular permeability and protein expression of ZO-1 through nicotinic acetylcholine receptors expressed on brain endothelial cells .
10399139	0	acetylcholine	122,135	acetylcholinesterase	14,34	acetylcholine	acetylcholinesterase	MESH:D000109	83817(Tax:10116)	Chemical	Gene	deficit|amod|START_ENTITY model|nmod|deficit galanthamine|nmod|model galanthamine|nsubj|Effect Effect|nmod|inhibitor inhibitor|amod|END_ENTITY	Effect of the acetylcholinesterase inhibitor galanthamine on learning and memory in prolonged alcohol intake rat model of acetylcholine deficit .
11303072	0	acetylcholine	27,40	acetylcholinesterase	52,72	acetylcholine	acetylcholinesterase	MESH:D000109	43	Chemical	Gene	molecules|compound|START_ENTITY molecules|compound|END_ENTITY	Force spectroscopy between acetylcholine and single acetylcholinesterase molecules and the effects of inhibitors and reactivators studied by atomic force microscopy .
11876771	0	acetylcholine	14,27	acetylcholinesterase	123,143	acetylcholine	acetylcholinesterase	MESH:D000109	11423(Tax:10090)	Chemical	Gene	release|amod|START_ENTITY Regulation|nmod|release depends|nsubj|Regulation depends|nmod|activity activity|nmod|END_ENTITY	Regulation of acetylcholine release by muscarinic receptors at the mouse neuromuscular junction depends on the activity of acetylcholinesterase .
12649387	0	acetylcholine	61,74	acetylcholinesterase	206,226	acetylcholine	acetylcholinesterase	MESH:D000109	83817(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY enhances|dobj|release enhances|advcl|talipexole talipexole|nmod|absence absence|nmod|inhibitors inhibitors|amod|END_ENTITY	Piribedil enhances frontocortical and hippocampal release of acetylcholine in freely moving rats by blockade of alpha 2A-adrenoceptors : a dialysis comparison to talipexole and quinelorane in the absence of acetylcholinesterase inhibitors .
12667913	0	acetylcholine	25,38	acetylcholinesterase	60,80	acetylcholine	acetylcholinesterase	MESH:D000109	11423(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY Regulation|nmod|receptor function|nsubj|Regulation function|nmod|mice mice|amod|END_ENTITY	Regulation of muscarinic acetylcholine receptor function in acetylcholinesterase knockout mice .
14627729	0	acetylcholine	56,69	acetylcholinesterase	73,93	acetylcholine	acetylcholinesterase	MESH:D000109	43	Chemical	Gene	binding|nmod|START_ENTITY binding|acl|END_ENTITY	Studying the roles of W86 , E202 , and Y337 in binding of acetylcholine to acetylcholinesterase using a combined molecular dynamics and multiple docking approach .
14644616	0	acetylcholine	68,81	acetylcholinesterase	106,126	acetylcholine	acetylcholinesterase	MESH:D000109	83817(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY pesticides|nmod|receptors effects|nmod|pesticides END_ENTITY|nsubj|effects	Selective effects of carbamate pesticides on rat neuronal nicotinic acetylcholine receptors and rat brain acetylcholinesterase .
15009674	0	acetylcholine	17,30	acetylcholinesterase	97,117	acetylcholine	acetylcholinesterase	MESH:D000109	43	Chemical	Gene	receptors|compound|START_ENTITY mediate|nsubj|receptors mediate|dobj|Abeta Abeta|acl:relcl|induced induced|nmod|level level|nmod|END_ENTITY	Alpha7-nicotinic acetylcholine receptors mediate an Abeta -LRB- 1-42 -RRB- - induced increase in the level of acetylcholinesterase in primary cortical neurones .
15318343	0	acetylcholine	8,21	acetylcholinesterase	132,152	acetylcholine	acetylcholinesterase	MESH:D000109	11423(Tax:10090)	Chemical	Gene	density|amod|START_ENTITY sustain|nsubj|density sustain|nmod|mice mice|amod|END_ENTITY	Reduced acetylcholine receptor density , morphological remodeling , and butyrylcholinesterase activity can sustain muscle function in acetylcholinesterase knockout mice .
15322258	0	acetylcholine	24,37	acetylcholinesterase	67,87	acetylcholine	acetylcholinesterase	MESH:D000109	83817(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY Regulation|nmod|channel function|nsubj|Regulation function|nmod|inhibitors inhibitors|amod|END_ENTITY	Regulation of nicotinic acetylcholine receptor channel function by acetylcholinesterase inhibitors in rat hippocampal CA1 interneurons .
15801847	0	acetylcholine	67,80	acetylcholinesterase	119,139	acetylcholine	acetylcholinesterase	MESH:D000109	43	Chemical	Gene	analogue|compound|START_ENTITY fluoroethylpiperidin-4ylmethyl_acetate|dep|analogue measurement|amod|fluoroethylpiperidin-4ylmethyl_acetate measurement|nmod|activity activity|compound|END_ENTITY	N - -LSB- 18F -RSB- _ fluoroethylpiperidin-4ylmethyl_acetate , a novel lipophilic acetylcholine analogue for PET measurement of brain acetylcholinesterase activity .
16540146	0	acetylcholine	25,38	acetylcholinesterase	87,107	acetylcholine	acetylcholinesterase	MESH:D000109	41625(Tax:7227)	Chemical	Gene	hydrolysis|amod|START_ENTITY study|nmod|hydrolysis catalyzed|nsubj|study catalyzed|nmod|END_ENTITY	A semiempirical study of acetylcholine hydrolysis catalyzed by Drosophila_melanogaster acetylcholinesterase .
16677771	0	acetylcholine	91,104	acetylcholinesterase	143,163	acetylcholine	acetylcholinesterase	MESH:D000109	83817(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY change|nmod|release causes|dobj|change causes|nmod|compensation compensation|nmod|receptors receptors|amod|END_ENTITY	Behavioral_depression in the swim test causes a biphasic , long-lasting change in accumbens acetylcholine release , with partial compensation by acetylcholinesterase and muscarinic-1 receptors .
17068780	0	acetylcholine	135,148	acetylcholinesterase	10,30	acetylcholine	acetylcholinesterase	MESH:D000109	83817(Tax:10116)	Chemical	Gene	competition|amod|START_ENTITY measure|nmod|competition Effect|dep|measure Effect|nmod|inhibitors inhibitors|amod|END_ENTITY	Effect of acetylcholinesterase inhibitors on the binding of nicotinic alpha4beta2 receptor PET radiotracer , -LRB- 18 -RRB- F-nifene : A measure of acetylcholine competition .
1732764	0	acetylcholine	14,27	acetylcholinesterase	61,81	acetylcholine	acetylcholinesterase	MESH:D000109	43	Chemical	Gene	receptors|amod|START_ENTITY receptors|nmod|case case|nmod|deficiency deficiency|compound|END_ENTITY	Deficiency of acetylcholine receptors in a case of end-plate acetylcholinesterase deficiency : a histochemical investigation .
17805515	0	acetylcholine	21,34	acetylcholinesterase	107,127	acetylcholine	acetylcholinesterase	MESH:D000109	11423(Tax:10090)	Chemical	Gene	Adaptation|nmod|START_ENTITY Adaptation|nmod|lungs lungs|nmod|mice mice|amod|END_ENTITY	Adaptation to excess acetylcholine by downregulation of adrenoceptors and muscarinic receptors in lungs of acetylcholinesterase knockout mice .
18052268	0	acetylcholine	25,38	acetylcholinesterase	54,74	acetylcholine	acetylcholinesterase	MESH:D000109	43	Chemical	Gene	consumption|amod|START_ENTITY consumption|nmod|END_ENTITY	Continuum simulations of acetylcholine consumption by acetylcholinesterase : a Poisson-Nernst-Planck approach .
19021024	0	acetylcholine	10,23	acetylcholinesterase	127,147	acetylcholine	acetylcholinesterase	MESH:D000109	83817(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|dep|effect effect|nmod|treatment treatment|nmod|inhibitor inhibitor|amod|END_ENTITY	Vesicular acetylcholine transporter -LRB- VAChT -RRB- in the brain of spontaneously hypertensive rats -LRB- SHR -RRB- : effect of treatment with an acetylcholinesterase inhibitor .
22037292	0	acetylcholine	71,84	acetylcholinesterase	9,29	acetylcholine	acetylcholinesterase	MESH:D000109	43	Chemical	Gene	Assay|nmod|START_ENTITY Assay|nmod|activity activity|amod|END_ENTITY	Assay of acetylcholinesterase activity by potentiometric monitoring of acetylcholine .
2243615	0	acetylcholine	64,77	acetylcholinesterase	14,34	acetylcholine	acetylcholinesterase	MESH:D000109	83817(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY inhibition|nmod|release inhibition|amod|END_ENTITY	The effect of acetylcholinesterase inhibition on the release of acetylcholine from the striatum in vivo : interaction with autoreceptor responses .
22733599	0	acetylcholine	67,80	acetylcholinesterase	14,34	acetylcholine	acetylcholinesterase	MESH:D000109	83817(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|impact impact|nmod|inhibitors inhibitors|amod|END_ENTITY	The impact of acetylcholinesterase inhibitors on the extracellular acetylcholine concentrations in the adult rat brain : a meta-analysis .
23046821	0	acetylcholine	111,124	acetylcholinesterase	20,40	acetylcholine	acetylcholinesterase	MESH:D000109	11423(Tax:10090)	Chemical	Gene	receptors|amod|START_ENTITY antagonist|nmod|receptors antagonist|nsubj|APS12-2 APS12-2|amod|END_ENTITY	The non-competitive acetylcholinesterase inhibitor APS12-2 is a potent antagonist of skeletal muscle nicotinic acetylcholine receptors .
23085120	0	acetylcholine	147,160	acetylcholinesterase	28,48	acetylcholine	acetylcholinesterase	MESH:D000109	43	Chemical	Gene	receptor/phosphoinositide|nsubj|START_ENTITY activating|ccomp|receptor/phosphoinositide neuronal_excitotoxicity|acl|activating protects|nmod|neuronal_excitotoxicity protects|nsubj|Bis Bis|dep|hupyridone hupyridone|appos|inhibitor inhibitor|compound|END_ENTITY	Bis -LRB- 12 -RRB- - hupyridone , a novel acetylcholinesterase inhibitor , protects against glutamate-induced neuronal_excitotoxicity via activating a7 nicotinic acetylcholine receptor/phosphoinositide 3-kinase/Akt cascade .
23913347	0	acetylcholine	80,93	acetylcholinesterase	15,35	acetylcholine	acetylcholinesterase	MESH:D000109	83817(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|imaging imaging|nmod|effects effects|amod|END_ENTITY	PET imaging of acetylcholinesterase inhibitor-induced effects on a4b2 nicotinic acetylcholine receptor binding .
25371181	0	acetylcholine	50,63	acetylcholinesterase	73,93	acetylcholine	acetylcholinesterase	MESH:D000109	83817(Tax:10116)	Chemical	Gene	content|compound|START_ENTITY thyroxine|nmod|content Effects|nmod|thyroxine Effects|appos|activity activity|amod|END_ENTITY	Effects of thyroxine and donepezil on hippocampal acetylcholine content , acetylcholinesterase activity , synaptotagmin-1 and SNAP-25 expression in hypothyroid adult rats .
2552204	0	acetylcholine	114,127	acetylcholinesterase	33,53	acetylcholine	acetylcholinesterase	MESH:D000109	83817(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY +|nmod|release +|nmod|activity activity|amod|END_ENTITY	Time dependence of Li + action on acetylcholinesterase activity in correlation with spontaneous quantal release of acetylcholine in rat diaphragm .
25979761	0	acetylcholine	125,138	acetylcholinesterase	73,93	acetylcholine	acetylcholinesterase	MESH:D000109	11423(Tax:10090)	Chemical	Gene	system|compound|START_ENTITY and|nmod|system and|appos|inhibitor inhibitor|amod|END_ENTITY	Nicotinic receptor-dependent and - independent effects of galantamine , an acetylcholinesterase inhibitor , on the non-neuronal acetylcholine system in C2C12 cells .
25979761	0	acetylcholine	125,138	acetylcholinesterase	73,93	acetylcholine	acetylcholinesterase	MESH:D000109	11423(Tax:10090)	Chemical	Gene	system|compound|START_ENTITY and|nmod|system and|appos|inhibitor inhibitor|amod|END_ENTITY	Nicotinic receptor-dependent and - independent effects of galantamine , an acetylcholinesterase inhibitor , on the non-neuronal acetylcholine system in C2C12 cells .
2768558	0	acetylcholine	69,82	acetylcholinesterase	18,38	acetylcholine	acetylcholinesterase	MESH:D000109	406104(Tax:7460)	Chemical	Gene	antigen|amod|START_ENTITY Histochemistry|nmod|antigen Histochemistry|nmod|END_ENTITY	Histochemistry of acetylcholinesterase and immunocytochemistry of an acetylcholine receptor-like antigen in the brain of the honeybee .
3736119	0	acetylcholine	147,160	acetylcholinesterase	51,71	acetylcholine	acetylcholinesterase	MESH:D000109	43	Chemical	Gene	using|dobj|START_ENTITY extracts|xcomp|using extracts|nsubj|method method|acl|measuring measuring|dobj|activity activity|amod|END_ENTITY	A semi-automated fluorimetric method for measuring acetylcholinesterase activity in small volumes of cerebrospinal fluid and tissue extracts using acetylcholine as substrate .
3768708	0	acetylcholine	43,56	acetylcholinesterase	109,129	acetylcholine	acetylcholinesterase	MESH:D000109	83817(Tax:10116)	Chemical	Gene	breakdown|nmod|START_ENTITY breakdown|dep|form form|nmod|END_ENTITY	Veratridine-induced breakdown of cytosolic acetylcholine in rat hippocampal minces : an intraterminal form of acetylcholinesterase or choline_O-acetyltransferase ?
4010772	0	acetylcholine	46,59	acetylcholinesterase	14,34	acetylcholine	acetylcholinesterase	MESH:D000109	43	Chemical	Gene	factor|amod|START_ENTITY induced|nmod|factor induced|nsubj|Aggregates Aggregates|nmod|END_ENTITY	Aggregates of acetylcholinesterase induced by acetylcholine receptor-aggregating factor .
4089884	0	acetylcholine	44,57	acetylcholinesterase	67,87	acetylcholine	acetylcholinesterase	MESH:D000109	11423(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|activity activity|amod|END_ENTITY	Effects of insecticidal carbamates on brain acetylcholine content , acetylcholinesterase activity and behavior in mice .
4517944	0	acetylcholine	14,27	acetylcholinesterase	53,73	acetylcholine	acetylcholinesterase	MESH:D000109	11423(Tax:10090)	Chemical	Gene	receptors|amod|START_ENTITY Regulation|nmod|receptors Regulation|acl|END_ENTITY	Regulation of acetylcholine receptors in relation to acetylcholinesterase in neuroblastoma cells .
6279208	0	acetylcholine	70,83	acetylcholinesterase	15,35	acetylcholine	acetylcholinesterase	MESH:D000109	43	Chemical	Gene	neurons|nmod|START_ENTITY microsomes|nmod|neurons level|nmod|microsomes level|amod|END_ENTITY	-LSB- Regulation of acetylcholinesterase level in microsomes of neurons by acetylcholine and cyclic_nucleotides -RSB- .
7448235	0	acetylcholine	13,26	acetylcholinesterase	51,71	acetylcholine	acetylcholinesterase	MESH:D000109	83817(Tax:10116)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of acetylcholine on rebinding of soluble acetylcholinesterase to a synaptosomal fraction from rat brain .
7448874	0	acetylcholine	47,60	acetylcholinesterase	13,33	acetylcholine	acetylcholinesterase	MESH:D000109	396388(Tax:9031)	Chemical	Gene	relation|acl|START_ENTITY Secretion|dep|relation Secretion|nmod|END_ENTITY	Secretion of acetylcholinesterase : relation to acetylcholine receptor metabolism .
7697367	0	acetylcholine	85,98	acetylcholinesterase	23,43	acetylcholine	acetylcholinesterase	MESH:D000109	43	Chemical	Gene	START_ENTITY|nsubj|measurement measurement|nmod|activity activity|amod|END_ENTITY	In vivo measurement of acetylcholinesterase activity in the brain with a radioactive acetylcholine analog .
8099964	0	acetylcholine	115,128	acetylcholinesterase	56,76	acetylcholine	acetylcholinesterase	MESH:D000109	489828(Tax:9615)	Chemical	Gene	activity|acl|START_ENTITY activity|nmod|derivatives derivatives|nmod|END_ENTITY	Inhibitory activity of camptothecin derivatives against acetylcholinesterase in dogs and their binding activity to acetylcholine receptors in rats .
8734490	0	acetylcholine	93,106	acetylcholinesterase	39,59	acetylcholine	acetylcholinesterase	MESH:D000109	83817(Tax:10116)	Chemical	Gene	levels|amod|START_ENTITY E2020|nmod|levels E2020|nsubj|effect effect|nmod|inhibitor inhibitor|compound|END_ENTITY	The effect of the selective reversible acetylcholinesterase inhibitor E2020 on extracellular acetylcholine and biogenic amine levels in rat cortex .
9143009	0	acetylcholine	194,207	acetylcholinesterase	68,88	acetylcholine	acetylcholinesterase	MESH:D000109	489828(Tax:9615)	Chemical	Gene	content|compound|START_ENTITY increase|nmod|content causes|dobj|increase causes|nsubj|administration administration|appos|agent agent|nmod|inhibitory inhibitory|amod|END_ENTITY	Oral administration of KW-5092 , a novel gastroprokinetic agent with acetylcholinesterase inhibitory and acetylcholine release enhancing activities , causes a dose-dependent increase in the blood acetylcholine content of beagle_dogs .
9234329	0	acetylcholine	37,50	acetylcholinesterase	77,97	acetylcholine	acetylcholinesterase	MESH:D000109	11423(Tax:10090)	Chemical	Gene	Design|nmod|START_ENTITY analogs|nsubj|Design analogs|advcl|mapping mapping|dobj|END_ENTITY	Design and evaluation of radioactive acetylcholine analogs for mapping brain acetylcholinesterase -LRB- AchE -RRB- in vivo .
9427520	0	acetylcholine	110,123	acetylcholinesterase	28,48	acetylcholine	acetylcholinesterase	MESH:D000109	43	Chemical	Gene	hydrolysis|amod|START_ENTITY rate|nmod|hydrolysis enhances|dobj|rate enhances|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	In vitro phosphorylation of acetylcholinesterase at non-consensus protein kinase A sites enhances the rate of acetylcholine hydrolysis .
9489729	0	acetylcholine	36,49	acetylcholinesterase	80,100	acetylcholine	acetylcholinesterase	MESH:D000109	43	Chemical	Gene	release|compound|START_ENTITY regulation|nmod|release regulation|dep|role role|nmod|inhibition inhibition|amod|END_ENTITY	Dopaminergic regulation of striatal acetylcholine release : the critical role of acetylcholinesterase inhibition .
9789819	0	acetylcholine	11,24	acetylcholinesterase	48,68	acetylcholine	acetylcholinesterase	MESH:D000109	43	Chemical	Gene	receptors|compound|START_ENTITY activate|nsubj|receptors activate|dobj|promoter promoter|amod|END_ENTITY	Muscarinic acetylcholine receptors activate the acetylcholinesterase gene promoter .
23351035	0	acetylcholine	77,90	acr-5	109,114	acetylcholine	acr-5	MESH:D000109	191596(Tax:6239)	Chemical	Gene	subunits|amod|START_ENTITY subunits|amod|END_ENTITY	Nicotine-motivated behavior in Caenorhabditis_elegans requires the nicotinic acetylcholine receptor subunits acr-5 and acr-15 .
8736640	0	acetylcholine	22,35	adenosine_A1_receptor	48,69	acetylcholine	adenosine A1 receptor	MESH:D000109	29290(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	In vivo regulation of acetylcholine release via adenosine_A1_receptor in rat cerebral cortex .
18502803	0	acetylcholine	10,23	agrin	104,109	acetylcholine	agrin	MESH:D000109	375790	Chemical	Gene	START_ENTITY|nmod|stimulation stimulation|nmod|END_ENTITY	Localized acetylcholine receptor clustering dynamics in response to microfluidic focal stimulation with agrin .
20566625	0	acetylcholine	72,85	agrin	125,130	acetylcholine	agrin	MESH:D000109	375790	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Asparagine of z8 insert is critical for the affinity , conformation , and acetylcholine receptor-clustering activity of neural agrin .
1280762	0	acetylcholine	51,64	alpha-chain	30,41	acetylcholine	alpha-chain	MESH:D000109	2217	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	Profile of the regions on the alpha-chain of human acetylcholine receptor recognized by autoantibodies in myasthenia_gravis .
2012611	0	acetylcholine	89,102	alpha-chain	44,55	acetylcholine	alpha-chain	MESH:D000109	2217	Chemical	Gene	START_ENTITY|nsubj|regions regions|nmod|END_ENTITY	The short-neurotoxin-binding regions on the alpha-chain of human and Torpedo californica acetylcholine receptors .
6525183	0	acetylcholine	107,120	alpha-chain	68,79	acetylcholine	alpha-chain	MESH:D000109	2217	Chemical	Gene	START_ENTITY|nsubj|Localization Localization|nmod|site site|nmod|END_ENTITY	Localization and synthesis of the acetylcholine-binding site in the alpha-chain of the Torpedo californica acetylcholine receptor .
2304905	0	acetylcholine	13,26	alpha-subunit	36,49	acetylcholine	alpha-subunit	MESH:D000109	395381(Tax:9031)	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Induction of acetylcholine receptor alpha-subunit gene expression in chicken myotubes by blocking electrical activity requires ongoing protein synthesis .
2721497	0	acetylcholine	100,113	alpha-subunit	63,76	acetylcholine	alpha-subunit	MESH:D000109	395381(Tax:9031)	Chemical	Gene	receptor|compound|START_ENTITY gene|nmod|receptor gene|amod|END_ENTITY	Interaction of nuclear factors with the upstream region of the alpha-subunit gene of chicken muscle acetylcholine receptor : variations with muscle differentiation and denervation .
2989833	0	acetylcholine	33,46	alpha-subunit	56,69	acetylcholine	alpha-subunit	MESH:D000109	395381(Tax:9031)	Chemical	Gene	mRNA|amod|START_ENTITY mRNA|compound|END_ENTITY	Activity regulates the levels of acetylcholine receptor alpha-subunit mRNA in cultured chicken myotubes .
10318955	0	acetylcholine	92,105	alpha3	66,72	acetylcholine	alpha3	MESH:D000109	110834(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Megacystis , mydriasis , and ion channel defect in mice lacking the alpha3 neuronal nicotinic acetylcholine receptor .
12594236	0	acetylcholine	44,57	alpha3	27,33	acetylcholine	alpha3	MESH:D000109	110834(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Central role of fibroblast alpha3 nicotinic acetylcholine receptor in mediating cutaneous effects of nicotine .
9681478	0	acetylcholine	54,67	alpha3	2,8	acetylcholine	alpha3	MESH:D000109	31767(Tax:7227)	Chemical	Gene	receptors|compound|START_ENTITY subunit|nmod|receptors END_ENTITY|appos|subunit	D alpha3 , a new functional alpha subunit of nicotinic acetylcholine receptors from Drosophila .
11809862	0	acetylcholine	75,88	alpha3/beta4	43,55	acetylcholine	alpha3/beta4	MESH:D000109	10381	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Protons enhance the gating kinetics of the alpha3/beta4 neuronal nicotinic acetylcholine receptor by increasing its apparent affinity to agonists .
10679230	0	acetylcholine	93,106	alpha4	140,146	acetylcholine	alpha4	MESH:D000109	3476	Chemical	Gene	alpha5|amod|START_ENTITY alpha5|dep|END_ENTITY	Nicotine binding to native and substituted peptides comprising residues 188-207 of nicotinic acetylcholine receptor alpha1 , alpha2 , alpha3 , alpha4 , alpha5 , and alpha7 subunits .
12713636	0	acetylcholine	104,117	alpha4	67,73	acetylcholine	alpha4	MESH:D000109	18518(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY subunit|nmod|receptors subunit|amod|END_ENTITY	Effects of nicotine in the dopaminergic system of mice lacking the alpha4 subunit of neuronal nicotinic acetylcholine receptors .
12781587	0	acetylcholine	18,31	alpha4	50,56	acetylcholine	alpha4	MESH:D000109	3476	Chemical	Gene	receptor|compound|START_ENTITY Loss|nmod|receptor subunits|nsubj|Loss subunits|dobj|END_ENTITY	Loss of nicotinic acetylcholine receptor subunits alpha4 and alpha7 in the cerebral cortex of Parkinson patients .
17132685	0	acetylcholine	105,118	alpha4	26,32	acetylcholine	alpha4	MESH:D000109	3476	Chemical	Gene	receptors|compound|START_ENTITY beta2|dep|receptors that|nmod|beta2 exceeds|dobj|that exceeds|nsubj|permeability permeability|nmod|END_ENTITY	Ca2 + permeability of the -LRB- alpha4 -RRB- 3 -LRB- beta2 -RRB- 2 stoichiometry greatly exceeds that of -LRB- alpha4 -RRB- 2 -LRB- beta2 -RRB- 3 human acetylcholine receptors .
17132685	0	acetylcholine	105,118	alpha4	82,88	acetylcholine	alpha4	MESH:D000109	3476	Chemical	Gene	receptors|compound|START_ENTITY beta2|dep|receptors beta2|dep|END_ENTITY	Ca2 + permeability of the -LRB- alpha4 -RRB- 3 -LRB- beta2 -RRB- 2 stoichiometry greatly exceeds that of -LRB- alpha4 -RRB- 2 -LRB- beta2 -RRB- 3 human acetylcholine receptors .
17631923	0	acetylcholine	236,249	alpha4	33,39	acetylcholine	alpha4	MESH:D000109	18518(Tax:10090)	Chemical	Gene	contribute|nmod|START_ENTITY contribute|nsubj|subunits subunits|amod|END_ENTITY	Gene targeting demonstrates that alpha4 nicotinic acetylcholine receptor subunits contribute to expression of diverse -LSB- 3H -RSB- epibatidine binding sites and components of biphasic 86Rb + efflux with high and low sensitivity to stimulation by acetylcholine .
17631923	0	acetylcholine	50,63	alpha4	33,39	acetylcholine	alpha4	MESH:D000109	18518(Tax:10090)	Chemical	Gene	subunits|amod|START_ENTITY subunits|amod|END_ENTITY	Gene targeting demonstrates that alpha4 nicotinic acetylcholine receptor subunits contribute to expression of diverse -LSB- 3H -RSB- epibatidine binding sites and components of biphasic 86Rb + efflux with high and low sensitivity to stimulation by acetylcholine .
18762859	0	acetylcholine	96,109	alpha4	48,54	acetylcholine	alpha4	MESH:D000109	3476	Chemical	Gene	genes|amod|START_ENTITY analysis|nmod|genes analysis|nmod|subunits subunits|amod|END_ENTITY	Genetic association analysis of tagging SNPs in alpha4 and beta2 subunits of neuronal nicotinic acetylcholine receptor genes -LRB- CHRNA4 and CHRNB2 -RRB- with schizophrenia in the Japanese population .
20157241	0	acetylcholine	52,65	alpha4	77,83	acetylcholine	alpha4	MESH:D000109	3476	Chemical	Gene	receptors|compound|START_ENTITY receptors|dep|END_ENTITY	Cholinesterase activity and mRNA level of nicotinic acetylcholine receptors -LRB- alpha4 and beta2 Subunits -RRB- in blood of elderly Chinese diagnosed as Alzheimer 's _ disease .
9593888	0	acetylcholine	49,62	alpha4	81,87	acetylcholine	alpha4	MESH:D000109	3476	Chemical	Gene	receptor|compound|START_ENTITY aging|nmod|receptor Alterations|nmod|aging subunits|nsubj|Alterations subunits|dobj|expression expression|amod|END_ENTITY	Alterations with aging and ischemia in nicotinic acetylcholine receptor subunits alpha4 and beta2 messenger RNA expression in postmortem human putamen .
9685607	0	acetylcholine	61,74	alpha4	29,35	acetylcholine	alpha4	MESH:D000109	3476	Chemical	Gene	receptor|compound|START_ENTITY subunit|nmod|receptor subunit|amod|END_ENTITY	Distribution of mRNA for the alpha4 subunit of the nicotinic acetylcholine receptor in the human fetal brain .
9749753	0	acetylcholine	44,57	alpha4	67,73	acetylcholine	alpha4	MESH:D000109	18518(Tax:10090)	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Promoter analysis of the neuronal nicotinic acetylcholine receptor alpha4 gene : methylation and expression of the transgene .
19020025	0	acetylcholine	44,57	alpha4_and_alpha6	16,33	acetylcholine	alpha4 and alpha6	MESH:D000109	18518(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Crucial role of alpha4_and_alpha6 nicotinic acetylcholine receptor subunits from ventral tegmental area in systemic nicotine self-administration .
17920082	0	acetylcholine	101,114	alpha7	84,90	acetylcholine	alpha7	MESH:D000109	11441(Tax:10090)	Chemical	Gene	subunit|compound|START_ENTITY subunit|amod|END_ENTITY	Decreased_withdrawal_symptoms but normal tolerance to nicotine in mice null for the alpha7 nicotinic acetylcholine receptor subunit .
18187166	0	acetylcholine	28,41	alpha7	12,18	acetylcholine	alpha7	MESH:D000109	11441(Tax:10090)	Chemical	Gene	S_24795|amod|START_ENTITY S_24795|amod|END_ENTITY	The partial alpha7 nicotine acetylcholine receptor agonist S_24795 enhances long-term potentiation at CA3-CA1 synapses in the adult mouse hippocampus .
19812337	0	acetylcholine	81,94	alpha7	74,80	acetylcholine	alpha7	MESH:D000109	11441(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Mouse RIC-3 , an endoplasmic reticulum chaperone , promotes assembly of the alpha7 acetylcholine receptor through a cytoplasmic coiled-coil domain .
20203212	0	acetylcholine	57,70	alpha7	40,46	acetylcholine	alpha7	MESH:D000109	11441(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Prefrontal beta2 subunit-containing and alpha7 nicotinic acetylcholine receptors differentially control glutamatergic and cholinergic signaling .
10700617	0	acetylcholine	47,60	alpha9	30,36	acetylcholine	alpha9	MESH:D000109	771878(Tax:9031)	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Cloning and expression of the alpha9 nicotinic acetylcholine receptor subunit in cochlear hair cells of the chick .
17706194	0	acetylcholine	23,36	alpha9	16,22	acetylcholine	alpha9	MESH:D000109	104099(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	Central role of alpha9 acetylcholine receptor in coordinating keratinocyte adhesion and motility at the initiation of epithelialization .
14645658	0	acetylcholine	51,64	alpha_4	26,33	acetylcholine	alpha 4	MESH:D000109	3476	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Characterization of human alpha_4 beta_2-nicotinic acetylcholine receptors stably and heterologously expressed in native nicotinic receptor-null SH-EP1 human epithelial cells .
15026168	0	acetylcholine	98,111	alpha_4	42,49	acetylcholine	alpha 4	MESH:D000109	3476	Chemical	Gene	genes|compound|START_ENTITY neuronal|dobj|genes neuronal|nsubj|studies studies|nmod|END_ENTITY	Candidate gene association studies of the alpha_4 -LRB- CHRNA4 -RRB- and beta_2 -LRB- CHRNB2 -RRB- neuronal nicotinic acetylcholine receptor subunit genes in Alzheimer 's _ disease .
18337473	0	acetylcholine	99,112	alpha_4	55,62	acetylcholine	alpha 4	MESH:D000109	18518(Tax:10090)	Chemical	Gene	sensitivity|amod|START_ENTITY changes|dobj|sensitivity changes|nsubj|deletion deletion|nmod|END_ENTITY	Partial deletion of the nicotinic cholinergic receptor alpha_4 or beta_2 subunit genes changes the acetylcholine sensitivity of receptor-mediated 86Rb + efflux in cortex and thalamus and alters relative expression of alpha_4 and beta_2 subunits .
7527290	0	acetylcholine	79,92	alpha_4	0,7	acetylcholine	alpha 4	MESH:D000109	18518(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY pharmacology|nmod|receptors combination|dobj|pharmacology combination|nsubj|beta beta|amod|END_ENTITY	alpha_4 beta 2 subunit combination specific pharmacology of neuronal nicotinic acetylcholine receptors in N1E-115 neuroblastoma cells .
7721089	0	acetylcholine	99,112	alpha_4	61,68	acetylcholine	alpha 4	MESH:D000109	3476	Chemical	Gene	subunits|amod|START_ENTITY neuronal|dobj|subunits neuronal|nsubj|expression expression|nmod|genes genes|acl|encoding encoding|dobj|END_ENTITY	Cloning and transient expression of genes encoding the human alpha_4 and beta_2 neuronal nicotinic acetylcholine receptor -LRB- nAChR -RRB- subunits .
8558445	0	acetylcholine	91,104	alpha_4	105,112	acetylcholine	alpha 4	MESH:D000109	3476	Chemical	Gene	START_ENTITY|dobj|receptor receptor|amod|END_ENTITY	Stable expression , pharmacologic properties and regulation of the human neuronal nicotinic acetylcholine alpha_4 beta 2 receptor .
14982698	0	acetylcholine	75,88	beta2	59,64	acetylcholine	beta2	MESH:D000109	15130(Tax:10090)	Chemical	Gene	subunit|amod|START_ENTITY subunit|amod|END_ENTITY	Null mutant analysis of responses to nicotine : deletion of beta2 nicotinic acetylcholine receptor subunit but not alpha7 subunit reduces sensitivity to nicotine-induced locomotor_depression and hypothermia .
15266026	0	acetylcholine	80,93	beta2	27,32	acetylcholine	beta2	MESH:D000109	10242	Chemical	Gene	receptors|compound|START_ENTITY modulation|nmod|receptors modulation|nmod|subunits subunits|amod|END_ENTITY	Differential modulation of beta2 and beta4 subunits of human neuronal nicotinic acetylcholine receptors by acidification .
15456819	0	acetylcholine	119,132	beta2	88,93	acetylcholine	beta2	MESH:D000109	15130(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY subunit|nmod|receptor subunit|amod|END_ENTITY	Visual response properties in the dorsal lateral geniculate nucleus of mice lacking the beta2 subunit of the nicotinic acetylcholine receptor .
15694199	0	acetylcholine	38,51	beta2	61,66	acetylcholine	beta2	MESH:D000109	15130(Tax:10090)	Chemical	Gene	subunits|compound|START_ENTITY subunits|amod|END_ENTITY	Hidden function of neuronal nicotinic acetylcholine receptor beta2 subunits in ganglionic transmission : comparison to alpha5_and_beta4 subunits .
15771418	0	acetylcholine	169,182	beta2	204,209	acetylcholine	beta2	MESH:D000109	10242	Chemical	Gene	receptors|compound|START_ENTITY receptors|acl|containing containing|dobj|subunits subunits|amod|END_ENTITY	Novel pyridyl ring C5 substituted analogues of epibatidine and 3 - -LRB- 1-methyl-2 -LRB- S -RRB- - pyrrolidinylmethoxy -RRB- pyridine -LRB- A-84543 -RRB- as highly selective agents for neuronal nicotinic acetylcholine receptors containing beta2 subunits .
15788760	0	acetylcholine	25,38	beta2	56,61	acetylcholine	beta2	MESH:D000109	15130(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY Requirement|nmod|receptor subunit|nsubj|Requirement subunit|dobj|END_ENTITY	Requirement of nicotinic acetylcholine receptor subunit beta2 in the maintenance of spiral_ganglion_neurons during aging .
16416156	0	acetylcholine	50,63	beta2	4,9	acetylcholine	beta2	MESH:D000109	15130(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY subunit|nmod|receptor subunit|amod|END_ENTITY	The beta2 but not alpha7 subunit of the nicotinic acetylcholine receptor is required for nicotine-conditioned place preference in mice .
16928859	0	acetylcholine	81,94	beta2	64,69	acetylcholine	beta2	MESH:D000109	10242	Chemical	Gene	receptors|compound|START_ENTITY levels|dep|receptors levels|nmod|END_ENTITY	Human tobacco smokers in early abstinence have higher levels of beta2 * nicotinic acetylcholine receptors than nonsmokers .
17132685	0	acetylcholine	105,118	beta2	35,40	acetylcholine	beta2	MESH:D000109	10242	Chemical	Gene	receptors|compound|START_ENTITY beta2|dep|receptors that|nmod|beta2 exceeds|dobj|that exceeds|nsubj|permeability permeability|nmod|alpha4 alpha4|appos|END_ENTITY	Ca2 + permeability of the -LRB- alpha4 -RRB- 3 -LRB- beta2 -RRB- 2 stoichiometry greatly exceeds that of -LRB- alpha4 -RRB- 2 -LRB- beta2 -RRB- 3 human acetylcholine receptors .
17132685	0	acetylcholine	105,118	beta2	91,96	acetylcholine	beta2	MESH:D000109	10242	Chemical	Gene	receptors|compound|START_ENTITY END_ENTITY|dep|receptors	Ca2 + permeability of the -LRB- alpha4 -RRB- 3 -LRB- beta2 -RRB- 2 stoichiometry greatly exceeds that of -LRB- alpha4 -RRB- 2 -LRB- beta2 -RRB- 3 human acetylcholine receptors .
17640815	0	acetylcholine	65,78	beta2	30,35	acetylcholine	beta2	MESH:D000109	10242	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Lack of RIC-3 congruence with beta2 subunit-containing nicotinic acetylcholine receptors in bipolar_disorder .
18077321	0	acetylcholine	62,75	beta2	31,36	acetylcholine	beta2	MESH:D000109	15130(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY subunit|nmod|receptor subunit|amod|END_ENTITY	Intracellular complexes of the beta2 subunit of the nicotinic acetylcholine receptor in brain identified by proteomics .
18190729	0	acetylcholine	16,29	beta2	0,5	acetylcholine	beta2	MESH:D000109	10242	Chemical	Gene	START_ENTITY|nsubj|Nicotinic Nicotinic|compound|END_ENTITY	beta2 Nicotinic acetylcholine receptor availability in post-traumatic_stress_disorder .
18757739	0	acetylcholine	65,78	beta2	34,39	acetylcholine	beta2	MESH:D000109	15130(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY subunit|nmod|receptor subunit|amod|END_ENTITY	Retinal waves in mice lacking the beta2 subunit of the nicotinic acetylcholine receptor .
19200240	0	acetylcholine	141,154	beta2	106,111	acetylcholine	beta2	MESH:D000109	15130(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Nicotine withdrawal-induced_deficits in trace fear conditioning in C57BL/6 mice -- a role for high-affinity beta2 subunit-containing nicotinic acetylcholine receptors .
19828805	0	acetylcholine	129,142	beta2	102,107	acetylcholine	beta2	MESH:D000109	15130(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY subunit|nmod|receptor subunit|amod|END_ENTITY	Direction-specific disruption of subcortical visual_behavior and receptive fields in mice lacking the beta2 subunit of nicotinic acetylcholine receptor .
10531434	0	acetylcholine	104,117	beta4	67,72	acetylcholine	beta4	MESH:D000109	140489(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY subunits|nmod|receptors subunits|amod|END_ENTITY	Multiorgan autonomic_dysfunction in mice lacking the beta2 and the beta4 subunits of neuronal nicotinic acetylcholine receptors .
12021403	0	acetylcholine	86,99	beta4	70,75	acetylcholine	beta4	MESH:D000109	10381	Chemical	Gene	subunits|amod|START_ENTITY subunits|amod|END_ENTITY	First and second transmembrane segments of alpha3 , _ alpha4 , beta2 , and beta4 nicotinic acetylcholine receptor subunits influence the efficacy and potency of nicotine .
15275829	0	acetylcholine	31,44	beta4	15,20	acetylcholine	beta4	MESH:D000109	140489(Tax:10090)	Chemical	Gene	subunits|amod|START_ENTITY subunits|amod|END_ENTITY	The alpha3 and beta4 nicotinic acetylcholine receptor subunits are necessary for nicotine-induced seizures and hypolocomotion in mice .
15537871	0	acetylcholine	76,89	beta4	60,65	acetylcholine	beta4	MESH:D000109	140489(Tax:10090)	Chemical	Gene	subunit|compound|START_ENTITY subunit|amod|END_ENTITY	Decreased signs of nicotine withdrawal in mice null for the beta4 nicotinic acetylcholine receptor subunit .
9325332	0	acetylcholine	58,71	beta4	81,86	acetylcholine	beta4	MESH:D000109	10381	Chemical	Gene	receptor|compound|START_ENTITY gene|compound|receptor gene|amod|END_ENTITY	Sp1 and Sp3 regulate expression of the neuronal nicotinic acetylcholine receptor beta4 subunit gene .
15472930	0	acetylcholine	106,119	beta_2	65,71	acetylcholine	beta 2	MESH:D000109	15130(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY subunit|nmod|receptor subunit|amod|END_ENTITY	Alteration of hippocampal cell proliferation in mice lacking the beta_2 subunit of the neuronal nicotinic acetylcholine receptor .
7756618	0	acetylcholine	39,52	beta_2	22,28	acetylcholine	beta 2	MESH:D000109	10242	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Regulation of alpha 4 beta_2 nicotinic acetylcholine receptors in M10 cells following treatment with nicotinic agents .
8996215	0	acetylcholine	73,86	beta_2	107,113	acetylcholine	beta 2	MESH:D000109	10242	Chemical	Gene	receptors|compound|START_ENTITY receptors|dep|h h|dobj|END_ENTITY	Pharmacological characterization of recombinant human neuronal nicotinic acetylcholine receptors h alpha 2 beta_2 , h alpha 2 beta 4 , h alpha 3 beta_2 , h alpha 3 beta 4 , h alpha 4 beta_2 , h alpha 4 beta 4 and h alpha 7 expressed in Xenopus oocytes .
7852408	0	acetylcholine	34,47	beta_3	57,63	acetylcholine	beta 3	MESH:D000109	395164(Tax:9031)	Chemical	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Characterization of the nicotinic acetylcholine receptor beta_3 gene .
12606764	0	acetylcholine	24,37	beta_4	47,53	acetylcholine	beta 4	MESH:D000109	140489(Tax:10090)	Chemical	Gene	subunit|amod|START_ENTITY subunit|amod|END_ENTITY	Deficiency of nicotinic acetylcholine receptor beta_4 subunit causes autonomic cardiac and intestinal_dysfunction .
11755783	0	acetylcholine	16,29	bone_morphogenetic_protein_9	43,71	acetylcholine	bone morphogenetic protein 9	MESH:D000109	12165(Tax:10090)	Chemical	Gene	synthesis|amod|START_ENTITY Upregulation|nmod|synthesis Upregulation|nmod|END_ENTITY	Upregulation of acetylcholine synthesis by bone_morphogenetic_protein_9 in a murine septal cell line .
7797492	0	acetylcholine	98,111	calnexin	44,52	acetylcholine	calnexin	MESH:D000109	416288(Tax:9031)	Chemical	Gene	receptors|compound|START_ENTITY END_ENTITY|nmod|receptors	Role of the endoplasmic reticulum chaperone calnexin in subunit folding and assembly of nicotinic acetylcholine receptors .
11784782	0	acetylcholine	80,93	catestatin	47,57	acetylcholine	catestatin	MESH:D000109	1113	Chemical	Gene	receptors|compound|START_ENTITY END_ENTITY|nmod|receptors	Modulatory mechanism of the endogenous peptide catestatin on neuronal nicotinic acetylcholine receptors and exocytosis .
26079001	0	acetylcholine	61,74	catestatin	30,40	acetylcholine	catestatin	MESH:D000109	1113	Chemical	Gene	receptors|compound|START_ENTITY docked|nmod|receptors docked|nsubj|study study|nmod|END_ENTITY	A molecular dynamics study of catestatin docked on nicotinic acetylcholine receptors to identify amino_acids potentially involved in the binding of chromogranin_A fragments .
22981453	0	acetylcholine	14,27	cholecystokinin	39,54	acetylcholine	cholecystokinin	MESH:D000109	25298(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	Modulation of acetylcholine release by cholecystokinin in striatum : receptor specificity ; role of dopaminergic neuronal activity .
749543	0	acetylcholine	68,81	choline_acetylase	32,49	acetylcholine	choline acetylase	MESH:D000109	1103	Chemical	Gene	inhibitors|nmod|START_ENTITY inhibitors|amod|END_ENTITY	-LSB- In vitro and in vivo effect of choline_acetylase inhibitors on the acetylcholine levels of the central nervous system -RSB- .
10501193	0	acetylcholine	148,161	choline_acetyltransferase	101,126	acetylcholine	choline acetyltransferase	MESH:D000109	290567(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY and/or|dobj|transporter and/or|nsubj|release release|nmod|cells cells|amod|modified modified|xcomp|express express|dobj|END_ENTITY	Evoked acetylcholine release by immortalized brain endothelial cells genetically modified to express choline_acetyltransferase and/or the vesicular acetylcholine transporter .
10501193	0	acetylcholine	7,20	choline_acetyltransferase	101,126	acetylcholine	choline acetyltransferase	MESH:D000109	290567(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY release|nmod|cells cells|amod|modified modified|xcomp|express express|dobj|END_ENTITY	Evoked acetylcholine release by immortalized brain endothelial cells genetically modified to express choline_acetyltransferase and/or the vesicular acetylcholine transporter .
1468577	0	acetylcholine	9,22	choline_acetyltransferase	102,127	acetylcholine	choline acetyltransferase	MESH:D000109	290567(Tax:10116)	Chemical	Gene	secretion|compound|START_ENTITY transfected|nsubj|secretion transfected|nmod|cDNA cDNA|compound|END_ENTITY	Enhanced acetylcholine secretion in neuroblastoma x glioma hybrid NG108-15 cells transfected with rat choline_acetyltransferase cDNA .
1548478	0	acetylcholine	33,46	choline_acetyltransferase	131,156	acetylcholine	choline acetyltransferase	MESH:D000109	290567(Tax:10116)	Chemical	Gene	synthesis|nmod|START_ENTITY synthesis|dep|characterization characterization|nmod|END_ENTITY	High-level synthesis and fate of acetylcholine in baculovirus-infected cells : characterization and purification of recombinant rat choline_acetyltransferase .
22640809	0	acetylcholine	127,140	choline_acetyltransferase	87,112	acetylcholine	choline acetyltransferase	MESH:D000109	290567(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Single dose exposure of sarin and physostigmine differentially regulates expression of choline_acetyltransferase and vesicular acetylcholine transporter in rat brain .
24121130	0	acetylcholine	35,48	choline_acetyltransferase	107,132	acetylcholine	choline acetyltransferase	MESH:D000109	290567(Tax:10116)	Chemical	Gene	level|amod|START_ENTITY reduces|dobj|level reduces|nmod|striatum striatum|acl|disturbing disturbing|dobj|distribution distribution|nmod|END_ENTITY	Glycogen synthase kinase-3 reduces acetylcholine level in striatum via disturbing cellular distribution of choline_acetyltransferase in cholinergic interneurons in rats .
7673184	0	acetylcholine	69,82	choline_acetyltransferase	29,54	acetylcholine	choline acetyltransferase	MESH:D000109	12647(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|up-regulation up-regulation|nmod|END_ENTITY	Coordinated up-regulation of choline_acetyltransferase and vesicular acetylcholine transporter gene expression by the retinoic_acid_receptor_alpha , cAMP , and leukemia inhibitory factor/ciliary neurotrophic factor signaling pathways in a murine septal cell line .
7792084	0	acetylcholine	9,22	choline_acetyltransferase	81,106	acetylcholine	choline acetyltransferase	MESH:D000109	12647(Tax:10090)	Chemical	Gene	release|compound|START_ENTITY END_ENTITY|nsubj|release	Discrete acetylcholine release from neuroblastoma or hybrid cells overexpressing choline_acetyltransferase into the neuromuscular synaptic cleft .
8118686	0	acetylcholine	81,94	choline_acetyltransferase	12,37	acetylcholine	choline acetyltransferase	MESH:D000109	290567(Tax:10116)	Chemical	Gene	innervation|compound|START_ENTITY sprouting|nmod|innervation activity|acl|sprouting activity|amod|END_ENTITY	Recovery of choline_acetyltransferase activity without sprouting of the residual acetylcholine innervation in adult rat cerebral cortex after lesion of the nucleus basalis .
8294908	0	acetylcholine	31,44	choline_acetyltransferase	85,110	acetylcholine	choline acetyltransferase	MESH:D000109	12647(Tax:10090)	Chemical	Gene	cDNA|amod|START_ENTITY cDNA|amod|END_ENTITY	Calcium-independent release of acetylcholine from stable cell lines expressing mouse choline_acetyltransferase cDNA .
8376990	0	acetylcholine	34,47	choline_acetyltransferase	105,130	acetylcholine	choline acetyltransferase	MESH:D000109	290567(Tax:10116)	Chemical	Gene	production|nmod|START_ENTITY genetically|nsubj|production genetically|dep|modified modified|xcomp|express express|dobj|END_ENTITY	In vivo production and release of acetylcholine from primary fibroblasts genetically modified to express choline_acetyltransferase .
8392667	0	acetylcholine	19,32	choline_acetyltransferase	98,123	acetylcholine	choline acetyltransferase	MESH:D000109	290567(Tax:10116)	Chemical	Gene	synthesis|nmod|START_ENTITY dependent|nsubj|synthesis dependent|nmod|activity activity|compound|END_ENTITY	Basal synthesis of acetylcholine in hippocampal synaptosomes is not dependent upon membrane-bound choline_acetyltransferase activity .
8762000	0	acetylcholine	84,97	choline_acetyltransferase	44,69	acetylcholine	choline acetyltransferase	MESH:D000109	290567(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|upregulation upregulation|nmod|END_ENTITY	Developmental age-dependent upregulation of choline_acetyltransferase and vesicular acetylcholine transporter mRNA expression in neonatal rat septum by nerve growth factor .
9404820	0	acetylcholine	72,85	choline_acetyltransferase	32,57	acetylcholine	choline acetyltransferase	MESH:D000109	290567(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Changes Changes|nmod|levels levels|nmod|END_ENTITY	Changes of expression levels of choline_acetyltransferase and vesicular acetylcholine transporter mRNAs after transection of the hypoglossal nerve in adult rats .
9774155	0	acetylcholine	81,94	choline_acetyltransferase	40,65	acetylcholine	choline acetyltransferase	MESH:D000109	290567(Tax:10116)	Chemical	Gene	immunoreactivities|amod|START_ENTITY immunoreactivities|amod|END_ENTITY	Horizontal cells of the rat retina show choline_acetyltransferase - and vesicular acetylcholine transporter-like immunoreactivities during early postnatal developmental stages .
17010154	0	acetylcholine	12,25	choline_transporter	66,85	acetylcholine	choline transporter	MESH:D000109	63993(Tax:10090)	Chemical	Gene	homeostasis|amod|START_ENTITY homeostasis|nmod|END_ENTITY	Deficits in acetylcholine homeostasis , receptors and behaviors in choline_transporter heterozygous mice .
978479	0	acetylcholine	80,93	cholinesterase	32,46	acetylcholine	cholinesterase	MESH:D000109	395358(Tax:9031)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activity activity|amod|END_ENTITY	The effects of physostigmine on cholinesterase activity , storage and release of acetylcholine in the isolated chicken heart .
3492648	0	acetylcholine	22,35	corticotropin-releasing_factor	54,84	acetylcholine	corticotropin-releasing factor	MESH:D000109	81648(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|release release|amod|END_ENTITY	Stimulatory effect of acetylcholine on immunoreactive corticotropin-releasing_factor release from the rat hypothalamus in vitro .
11024458	0	acetylcholine	19,32	dalpha3	89,96	acetylcholine	dalpha3	MESH:D000109	31767(Tax:7227)	Chemical	Gene	receptors|compound|START_ENTITY receptors|dep|END_ENTITY	Neuronal nicotinic acetylcholine receptors of Drosophila_melanogaster : the alpha-subunit dalpha3 and the beta-type subunit ARD co-assemble within the same receptor complex .
8762105	0	acetylcholine	57,70	endothelin-1	14,26	acetylcholine	endothelin-1	MESH:D000109	100294653(Tax:9940)	Chemical	Gene	release|compound|START_ENTITY END_ENTITY|nmod|release	Inhibition by endothelin-1 of cholinergic nerve-mediated acetylcholine release and contraction in sheep isolated trachea .
6141249	0	acetylcholine	39,52	enkephalin	19,29	acetylcholine	enkephalin	MESH:D000109	29237(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY inhibits|dobj|release inhibits|nsubj|END_ENTITY	-LSB- D-Ala2 , D-Met5NH2 -RSB- - enkephalin inhibits acetylcholine release from the submucosal plexus of rat colon .
7566660	0	acetylcholine	39,52	epsilon-subunit	62,77	acetylcholine	epsilon-subunit	MESH:D000109	29422(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Involvement of extracellular matrix in acetylcholine receptor epsilon-subunit gene expression at the rat neuromuscular junction .
24365239	0	acetylcholine	54,67	focal_adhesion_kinase	14,35	acetylcholine	focal adhesion kinase	MESH:D000109	5747	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	Activation of focal_adhesion_kinase via M1 muscarinic acetylcholine receptor is required in restitution of intestinal barrier function after epithelial_injury .
11489302	0	acetylcholine	54,67	galanin	108,115	acetylcholine	galanin	MESH:D000109	14419(Tax:10090)	Chemical	Gene	release|compound|START_ENTITY release|nmod|transgenic_mice transgenic_mice|compound|END_ENTITY	Microdialysis in freely moving mice : determination of acetylcholine , serotonin and noradrenaline release in galanin transgenic_mice .
1384927	0	acetylcholine	45,58	galanin	17,24	acetylcholine	galanin	MESH:D000109	29141(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY induced|nmod|release induced|nsubj|Mechanism Mechanism|nmod|END_ENTITY	Mechanism of the galanin induced increase in acetylcholine release in vivo from striata of freely moving rats .
9349981	0	acetylcholine	8,21	gastrin	61,68	acetylcholine	gastrin	MESH:D000109	25320(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|secretion secretion|compound|END_ENTITY	Role of acetylcholine and gastrin-releasing_peptide -LRB- GRP -RRB- in gastrin secretion .
1709847	0	acetylcholine	40,53	growth_hormone	57,71	acetylcholine	growth hormone	MESH:D000109	2688	Chemical	Gene	START_ENTITY|nmod|states states|amod|END_ENTITY	Involvement of brain catecholamines and acetylcholine in growth_hormone deficiency states .
8206111	0	acetylcholine	31,44	growth_hormone	66,80	acetylcholine	growth hormone	MESH:D000109	2688	Chemical	Gene	agonists|amod|START_ENTITY agonists|nmod|secretion secretion|amod|END_ENTITY	Effects of direct and indirect acetylcholine receptor agonists on growth_hormone secretion in humans .
8586028	0	acetylcholine	40,53	growth_hormone	57,71	acetylcholine	growth hormone	MESH:D000109	2688	Chemical	Gene	START_ENTITY|nmod|states states|amod|END_ENTITY	Involvement of brain catecholamines and acetylcholine in growth_hormone hypersecretory states .
12767456	1	acetylcholine	63,76	insulin	82,89	acetylcholine	insulin	MESH:D000109	3630	Chemical	Gene	TNF-alpha|dep|START_ENTITY TNF-alpha|dep|END_ENTITY	A discussion on the role of ras , GABA , acetylcholine , NO , insulin , TNF-alpha , and long-chain polyunsaturated_fatty_acids in memory formation and consolidation .
6261532	2	acetylcholine	78,91	insulin	123,130	acetylcholine	insulin	MESH:D000109	397415(Tax:9823)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|nmod|END_ENTITY	The effect of acetylcholine on the pancreatic secretion of insulin and glucagon .
11910991	0	acetylcholine	136,149	interleukin-1_beta	70,88	acetylcholine	interleukin-1 beta	MESH:D000109	24494(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY response|acl|induced involved|nmod|response involved|nmod|effect effect|nmod|END_ENTITY	Vasoactive intestinal peptide is involved in the inhibitory effect of interleukin-1_beta on the jejunal contractile response induced by acetylcholine .
7562566	0	acetylcholine	44,57	interleukin-1_beta	87,105	acetylcholine	interleukin-1 beta	MESH:D000109	3553	Chemical	Gene	cascade|nmod|START_ENTITY release|nsubj|cascade release|nmod|END_ENTITY	Arachidonic_acid cascade and stimulation of acetylcholine release by human recombinant interleukin-1_beta in guinea_pig ileum .
8949656	0	acetylcholine	14,27	interleukin_1_beta	59,77	acetylcholine	interleukin 1 beta	MESH:D000109	24494(Tax:10116)	Chemical	Gene	Inhibition|nmod|START_ENTITY induced|nsubj|Inhibition induced|nmod|END_ENTITY	Inhibition of acetylcholine induced intestinal motility by interleukin_1_beta in the rat .
19025057	0	acetylcholine	21,34	monoamine_oxidase_A	38,57	acetylcholine	monoamine oxidase A	MESH:D000109	29253(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|compound|END_ENTITY	Inhibitory effect of acetylcholine on monoamine_oxidase_A and B activity in different parts of rat brain .
12133987	0	acetylcholine	49,62	monocyte_chemoattractant_protein_1	89,123	acetylcholine	monocyte chemoattractant protein 1	MESH:D000109	24770(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY receptor|nmod|END_ENTITY	Muscle responds to an antibody reactive with the acetylcholine receptor by up-regulating monocyte_chemoattractant_protein_1 : a chemokine with the potential to influence the severity and course of experimental myasthenia_gravis .
11145999	0	acetylcholine	29,42	nAChR	122,127	acetylcholine	nAChR	MESH:D000109	11441(Tax:10090)	Chemical	Gene	release|amod|START_ENTITY stimulate|dobj|release stimulate|parataxis|mediated mediated|nmod|END_ENTITY	Nicotinic agonists stimulate acetylcholine release from mouse interpeduncular nucleus : a function mediated by a different nAChR than dopamine release from striatum .
11146056	0	acetylcholine	24,37	nAChR	49,54	acetylcholine	nAChR	MESH:D000109	170945(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY Antagonist|nmod|receptors Antagonist|appos|END_ENTITY	Antagonist of nicotinic acetylcholine receptors -LRB- nAChR -RRB- enhances formalin-induced nociception in rats : tonic role of nAChRs in the control of pain following injury .
14762152	3	acetylcholine	568,581	nAChR	592,597	acetylcholine	nAChR	MESH:D000109	11441(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	The nicotine response was blocked by d-tubocurarine and mecamylamine but not alpha-bungarotoxin , indicating the presence of calcium permeable , non-alpha7 nicotinic acetylcholine receptor -LRB- nAChR -RRB- subtype .
17552523	3	acetylcholine	545,558	nAChR	569,574	acetylcholine	nAChR	MESH:D000109	1137	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Herein , we have examined the barriers to ion conductance and origins of ion selectivity in models of the cationic human alpha7 nicotinic acetylcholine receptor -LRB- nAChR -RRB- and the anionic alpha1 glycine receptor -LRB- GlyR -RRB- , based on the structure of Torpedo nAChR .
19552432	0	acetylcholine	120,133	nAChR	144,149	acetylcholine	nAChR	MESH:D000109	1137	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Octahydropyrrolo -LSB- 3,4-c -RSB- pyrrole : a diamine scaffold for construction of either alpha4beta2 or alpha7-selective nicotinic acetylcholine receptor -LRB- nAChR -RRB- ligands .
20377613	0	acetylcholine	60,73	nAChR	153,158	acetylcholine	nAChR	MESH:D000109	11441(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY properties|nmod|receptors properties|nmod|genes genes|compound|END_ENTITY	Biochemical and functional properties of distinct nicotinic acetylcholine receptors in the superior cervical ganglion of mice with targeted deletions of nAChR subunit genes .
20974182	0	acetylcholine	35,48	nAChR	59,64	acetylcholine	nAChR	MESH:D000109	11441(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Role of mouse cerebellar nicotinic acetylcholine receptor -LRB- nAChR -RRB- a -LRB- 4 -RRB- b -LRB- 2 -RRB- - and a -LRB- 7 -RRB- subtypes in the behavioral cross-tolerance between nicotine and ethanol-induced ataxia .
21143907	0	acetylcholine	29,42	nAChR	53,58	acetylcholine	nAChR	MESH:D000109	1137	Chemical	Gene	subunits|compound|START_ENTITY subunits|appos|END_ENTITY	TTF-1 regulates a5 nicotinic acetylcholine receptor -LRB- nAChR -RRB- subunits in proximal and distal lung epithelium .
21682884	0	acetylcholine	61,74	nAChR	85,90	acetylcholine	nAChR	MESH:D000109	11441(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Immunohistochemical detection and regulation of a5 nicotinic acetylcholine receptor -LRB- nAChR -RRB- subunits by FoxA2 during mouse lung organogenesis .
21873428	0	acetylcholine	46,59	nAChR	130,135	acetylcholine	nAChR	MESH:D000109	1137	Chemical	Gene	a5|amod|START_ENTITY modulate|nsubj|a5 modulate|dep|END_ENTITY	Reporter mutation studies show that nicotinic acetylcholine receptor -LRB- nAChR -RRB- a5 Subunits and/or variants modulate function of a6 * - nAChR .
21873428	0	acetylcholine	46,59	nAChR	70,75	acetylcholine	nAChR	MESH:D000109	1137	Chemical	Gene	a5|amod|START_ENTITY a5|appos|END_ENTITY	Reporter mutation studies show that nicotinic acetylcholine receptor -LRB- nAChR -RRB- a5 Subunits and/or variants modulate function of a6 * - nAChR .
23092294	0	acetylcholine	56,69	nAChR	80,85	acetylcholine	nAChR	MESH:D000109	11441(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Discovery of highly potent and selective a4b2-nicotinic acetylcholine receptor -LRB- nAChR -RRB- partial agonists containing an isoxazolylpyridine_ether scaffold that demonstrate antidepressant-like activity .
23238810	2	acetylcholine	445,458	nAChR	472,477	acetylcholine	nAChR	MESH:D000109	1137	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	We have investigated the synergistic effect of low-concentration inhaled anesthetics and rocuronium on inhibition of the inward current of the adult-type muscle nicotinic acetylcholine receptor -LRB- - nAChR -RRB- .
23352509	0	acetylcholine	123,136	nAChR	147,152	acetylcholine	nAChR	MESH:D000109	1137	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Pharmacological properties and predicted binding mode of arylmethylene_quinuclidine-like derivatives at the a3b4 nicotinic acetylcholine receptor -LRB- nAChR -RRB- .
23937977	0	acetylcholine	105,118	nAChR	129,134	acetylcholine	nAChR	MESH:D000109	1137	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Computational studies of novel carbonyl-containing diazabicyclic ligands interacting with a4b2 nicotinic acetylcholine receptor -LRB- nAChR -RRB- reveal alternative binding modes .
24886653	0	acetylcholine	117,130	nAChR	141,146	acetylcholine	nAChR	MESH:D000109	1137	Chemical	Gene	subunit|amod|START_ENTITY subunit|appos|END_ENTITY	Analysis of rare variations reveals roles of amino_acid residues in the N-terminal extracellular domain of nicotinic acetylcholine receptor -LRB- nAChR -RRB- alpha6 subunit in the functional expression of human alpha6 * - nAChRs .
9009220	0	acetylcholine	80,93	nAChR	104,109	acetylcholine	nAChR	MESH:D000109	1137	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor -LRB- nAChR -RRB- subunits beta3_and_beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32 .
9009220	0	acetylcholine	80,93	nAChR	160,165	acetylcholine	nAChR	MESH:D000109	1137	Chemical	Gene	receptor|compound|START_ENTITY encoding|dobj|receptor Cloning|acl|encoding subunits|nsubj|Cloning subunits|dobj|beta3_and_beta4 beta3_and_beta4|nmod|subunits subunits|compound|END_ENTITY	Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor -LRB- nAChR -RRB- subunits beta3_and_beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32 .
22722030	0	acetylcholine	36,49	nAchR	63,68	acetylcholine	nAchR	MESH:D000109	11441(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Activation of the alpha-7 nicotinic acetylcholine receptor -LRB- a7 nAchR -RRB- reverses referred mechanical_hyperalgesia induced by colonic_inflammation in mice .
1606501	0	acetylcholine	56,69	nerve_growth_factor	11,30	acetylcholine	nerve growth factor	MESH:D000109	310738(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY Effects|nmod|release Effects|nmod|END_ENTITY	Effects of nerve_growth_factor on cortical and striatal acetylcholine and dopamine release in rats with cortical devascularizing lesions .
15664710	0	acetylcholine	24,37	orexin_A	49,57	acetylcholine	orexin A	MESH:D000109	25723(Tax:10116)	Chemical	Gene	Stimulation|nmod|START_ENTITY release|nsubj|Stimulation release|nmod|END_ENTITY	Stimulation of cortical acetylcholine release by orexin_A .
7953692	0	acetylcholine	48,61	parathyroid_hormone	10,29	acetylcholine	parathyroid hormone	MESH:D000109	24694(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY Effect|nmod|release Effect|nmod|END_ENTITY	Effect of parathyroid_hormone and calcitonin on acetylcholine release in rat sympathetic superior cervical ganglion .
9733907	0	acetylcholine	53,66	peptide_YY	27,37	acetylcholine	peptide YY	MESH:D000109	287730(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY END_ENTITY|nmod|release	The effect of hypothalamic peptide_YY on hippocampal acetylcholine release in vivo : implications for limbic function in binge-eating behavior .
10329658	0	acetylcholine	89,102	phospholipase_D	40,55	acetylcholine	phospholipase D	MESH:D000109	2822	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	A role for rho-kinase in rho-controlled phospholipase_D stimulation by the m3 muscarinic acetylcholine receptor .
10565841	0	acetylcholine	109,122	phospholipase_D	79,94	acetylcholine	phospholipase D	MESH:D000109	2822	Chemical	Gene	inhibits|nmod|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	Activation of protein kinase A increases phospholipase_D activity and inhibits phospholipase_D activation by acetylcholine in tracheal smooth muscle .
11036069	0	acetylcholine	18,31	phospholipase_D	79,94	acetylcholine	phospholipase D	MESH:D000109	2822	Chemical	Gene	receptor|compound|START_ENTITY signals|nsubj|receptor signals|xcomp|END_ENTITY	The M3 muscarinic acetylcholine receptor expressed in HEK-293 cells signals to phospholipase_D via G12 but not Gq-type G proteins : regulators of G proteins as tools to dissect pertussis toxin-resistant G proteins in receptor-effector coupling .
11418117	0	acetylcholine	196,209	phospholipase_D	89,104	acetylcholine	phospholipase D	MESH:D000109	173876(Tax:6239)	Chemical	Gene	receptor|compound|START_ENTITY expressing|dobj|receptor inhibit|advcl|expressing inhibit|dobj|activation activation|amod|END_ENTITY	Phytosphingosine and C2-phytoceramide induce cell death and inhibit carbachol-stimulated phospholipase_D activation in Chinese_hamster_ovary cells expressing the Caenorhabditis_elegans muscarinic acetylcholine receptor .
2002344	0	acetylcholine	106,119	phospholipase_D	15,30	acetylcholine	phospholipase D	MESH:D000109	2822	Chemical	Gene	receptors|compound|START_ENTITY activation|nmod|receptors cells|nmod|activation activity|nmod|cells activity|amod|END_ENTITY	Stimulation of phospholipase_D activity in human neuroblastoma -LRB- LA-N-2 -RRB- cells by activation of muscarinic acetylcholine receptors or by phorbol_esters : relationship to phosphoinositide turnover .
2007563	0	acetylcholine	35,48	phospholipase_D	70,85	acetylcholine	phospholipase D	MESH:D000109	2822	Chemical	Gene	receptor|compound|START_ENTITY Coupling|nmod|receptor subtypes|nsubj|Coupling subtypes|xcomp|END_ENTITY	Coupling of transfected muscarinic acetylcholine receptor subtypes to phospholipase_D .
6508788	0	acetylcholine	70,83	phospholipase_D	13,28	acetylcholine	phospholipase D	MESH:D000109	2822	Chemical	Gene	synthesis|amod|START_ENTITY providing|nmod|synthesis role|acl|providing END_ENTITY|dep|role	Synaptosomal phospholipase_D : potential role in providing choline for acetylcholine synthesis .
22210165	0	acetylcholine	64,77	prolyl_oligopeptidase	14,35	acetylcholine	prolyl oligopeptidase	MESH:D000109	83471(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|inhibition inhibition|amod|END_ENTITY	The effect of prolyl_oligopeptidase inhibition on extracellular acetylcholine and dopamine levels in the rat striatum .
10414969	0	acetylcholine	71,84	rapsyn	9,15	acetylcholine	rapsyn	MESH:D000109	5913	Chemical	Gene	receptors|amod|START_ENTITY proteins|nmod|receptors Roles|nmod|proteins Roles|nmod|END_ENTITY	Roles of rapsyn and agrin in interaction of postsynaptic proteins with acetylcholine receptors .
10632581	0	acetylcholine	66,79	rapsyn	26,32	acetylcholine	rapsyn	MESH:D000109	5913	Chemical	Gene	receptor|compound|START_ENTITY cotargeted|nmod|receptor cotargeted|nsubjpass|END_ENTITY	The myristoylated protein rapsyn is cotargeted with the nicotinic acetylcholine receptor to the postsynaptic membrane via the exocytic pathway .
10740220	0	acetylcholine	67,80	rapsyn	18,24	acetylcholine	rapsyn	MESH:D000109	5913	Chemical	Gene	receptors|amod|START_ENTITY trafficking|nmod|receptors modifies|dobj|trafficking modifies|nsubj|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of rapsyn modifies the intracellular trafficking of acetylcholine receptors .
10859577	0	acetylcholine	48,61	rapsyn	18,24	acetylcholine	rapsyn	MESH:D000109	19400(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY inhibits|dobj|receptor inhibits|nsubj|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of rapsyn inhibits agrin-induced acetylcholine receptor clustering in muscle cells .
11087759	0	acetylcholine	98,111	rapsyn	8,14	acetylcholine	rapsyn	MESH:D000109	5913	Chemical	Gene	clustering|amod|START_ENTITY domains|nmod|clustering tetratricopeptide|dobj|domains tetratricopeptide|nsubj|Role Role|nmod|END_ENTITY	Role of rapsyn tetratricopeptide repeat and coiled-coil domains in self-association and nicotinic acetylcholine receptor clustering .
11466415	0	acetylcholine	28,41	rapsyn	69,75	acetylcholine	rapsyn	MESH:D000109	352942(Tax:7955)	Chemical	Gene	receptors|amod|START_ENTITY lacking|dobj|receptors zebrafish|acl|lacking fail|nsubj|zebrafish fail|xcomp|localize localize|dobj|clusters clusters|compound|END_ENTITY	Paralytic zebrafish lacking acetylcholine receptors fail to localize rapsyn clusters to the synapse .
12034776	0	acetylcholine	127,140	rapsyn	59,65	acetylcholine	rapsyn	MESH:D000109	5913	Chemical	Gene	receptors|compound|START_ENTITY requires|nmod|receptors requires|dobj|END_ENTITY	Laminin-1 redistributes postsynaptic proteins and requires rapsyn , tyrosine phosphorylation , and Src and Fyn to stably cluster acetylcholine receptors .
12486121	0	acetylcholine	48,61	rapsyn	16,22	acetylcholine	rapsyn	MESH:D000109	5913	Chemical	Gene	receptors|compound|START_ENTITY regulates|nmod|receptors regulates|dobj|interaction interaction|compound|END_ENTITY	Agrin regulates rapsyn interaction with surface acetylcholine receptors , and this underlies cytoskeletal anchoring and clustering .
16150851	0	acetylcholine	51,64	rapsyn	24,30	acetylcholine	rapsyn	MESH:D000109	362161(Tax:10116)	Chemical	Gene	loss|amod|START_ENTITY prevents|dobj|loss prevents|nsubj|expression expression|nmod|END_ENTITY	Increased expression of rapsyn in muscles prevents acetylcholine receptor loss in experimental autoimmune myasthenia_gravis .
16916845	0	acetylcholine	89,102	rapsyn	117,123	acetylcholine	rapsyn	MESH:D000109	5913	Chemical	Gene	receptor|amod|START_ENTITY co-clustering|nmod|receptor impairing|dobj|co-clustering impairing|nmod|END_ENTITY	CHRND mutation causes a congenital_myasthenic_syndrome by impairing co-clustering of the acetylcholine receptor with rapsyn .
17283077	0	acetylcholine	61,74	rapsyn	20,26	acetylcholine	rapsyn	MESH:D000109	5913	Chemical	Gene	clusters|compound|START_ENTITY protein|nmod|clusters protein|compound|END_ENTITY	The dynamics of the rapsyn scaffolding protein at individual acetylcholine receptor clusters .
17362913	0	acetylcholine	51,64	rapsyn	40,46	acetylcholine	rapsyn	MESH:D000109	19400(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY END_ENTITY|nmod|receptor	Developmental increase in the amount of rapsyn per acetylcholine receptor promotes postsynaptic receptor packing and stability .
17428970	0	acetylcholine	23,36	rapsyn	98,104	acetylcholine	rapsyn	MESH:D000109	5913	Chemical	Gene	receptor|amod|START_ENTITY receptor|acl|clustering clustering|nmod|interaction interaction|nmod|END_ENTITY	Beta-catenin regulates acetylcholine receptor clustering in muscle cells through interaction with rapsyn .
18987183	0	acetylcholine	33,46	rapsyn	101,107	acetylcholine	rapsyn	MESH:D000109	5913	Chemical	Gene	beta|amod|START_ENTITY motif|nmod|beta Identification|nmod|motif subunit|nsubj|Identification subunit|ccomp|regulates regulates|dobj|association association|compound|END_ENTITY	Identification of a motif in the acetylcholine receptor beta subunit whose phosphorylation regulates rapsyn association and postsynaptic receptor localization .
19344765	0	acetylcholine	35,48	rapsyn	10,16	acetylcholine	rapsyn	MESH:D000109	5913	Chemical	Gene	receptors|amod|START_ENTITY decreases|dobj|receptors decreases|nsubj|END_ENTITY	Silencing rapsyn in vivo decreases acetylcholine receptors and augments sodium channels and secondary postsynaptic membrane folding .
8918833	0	acetylcholine	110,123	rapsyn	31,37	acetylcholine	rapsyn	MESH:D000109	5913	Chemical	Gene	clusters|compound|START_ENTITY colocalized|nmod|clusters proteins|acl|colocalized phosphorylation|nmod|proteins regulates|dobj|phosphorylation regulates|nsubj|END_ENTITY	The synapse-associated protein rapsyn regulates tyrosine phosphorylation of proteins colocalized at nicotinic acetylcholine receptor clusters .
9185539	0	acetylcholine	62,75	rapsyn	117,123	acetylcholine	rapsyn	MESH:D000109	395986(Tax:9031)	Chemical	Gene	protein|amod|START_ENTITY protein|nmod|synapses synapses|appos|END_ENTITY	Chick ciliary ganglion neurons contain transcripts coding for acetylcholine receptor-associated protein at synapses -LRB- rapsyn -RRB- .
9520483	0	acetylcholine	23,36	rapsyn	67,73	acetylcholine	rapsyn	MESH:D000109	5913	Chemical	Gene	receptor|compound|START_ENTITY Mechanism|nmod|receptor cluster|nsubj|Mechanism cluster|nmod|END_ENTITY	Mechanism of nicotinic acetylcholine receptor cluster formation by rapsyn .
9604205	0	acetylcholine	51,64	rapsyn	22,28	acetylcholine	rapsyn	MESH:D000109	5913	Chemical	Gene	receptors|compound|START_ENTITY effects|nmod|receptors effects|nmod|END_ENTITY	Organizing effects of rapsyn on neuronal nicotinic acetylcholine receptors .
9698394	0	acetylcholine	82,95	rapsyn	66,72	acetylcholine	rapsyn	MESH:D000109	362161(Tax:10116)	Chemical	Gene	clustering|amod|START_ENTITY role|nmod|clustering domain|dep|role domain|nmod|END_ENTITY	The zinc finger domain of the 43-kDa_receptor-associated_protein , _ rapsyn : role in acetylcholine receptor clustering .
9789804	0	acetylcholine	13,26	rapsyn	47,53	acetylcholine	rapsyn	MESH:D000109	5913	Chemical	Gene	receptor|amod|START_ENTITY Targeting|nmod|receptor END_ENTITY|nsubj|Targeting	Targeting of acetylcholine receptor and 43 kDa rapsyn to the postsynaptic membrane in Torpedo marmorata electrocyte .
13679252	0	acetylcholine	34,47	somatostatin	69,81	acetylcholine	somatostatin	MESH:D000109	24797(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY release|dep|effect effect|nmod|END_ENTITY	Physiological release of striatal acetylcholine -LRB- in vivo -RRB- : effect of somatostatin on dopaminergic-cholinergic interaction .
1976754	0	acetylcholine	47,60	somatostatin	14,26	acetylcholine	somatostatin	MESH:D000109	24797(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY endogenous|dobj|release endogenous|nsubj|Evidence Evidence|dep|enhances enhances|nsubj|END_ENTITY	Evidence that somatostatin enhances endogenous acetylcholine release in the rat hippocampus .
2475031	0	acetylcholine	66,79	somatostatin	23,35	acetylcholine	somatostatin	MESH:D000109	100730851	Chemical	Gene	action|nmod|START_ENTITY action|nmod|END_ENTITY	Differential action of somatostatin on peptide-induced release of acetylcholine .
6191578	0	acetylcholine	32,45	substance_P	5,16	acetylcholine	substance P	MESH:D000109	6863	Chemical	Gene	mucosa|amod|START_ENTITY comediate|nmod|mucosa comediate|nsubj|END_ENTITY	Does substance_P comediate with acetylcholine in nerves of opossum esophageal muscularis mucosa ?
7509439	0	acetylcholine	68,81	substance_P	39,50	acetylcholine	substance P	MESH:D000109	6863	Chemical	Gene	receptor|compound|START_ENTITY -RSB-|nmod|receptor -RSB-|dobj|END_ENTITY	Characterization of the binding of -LSB- 3H -RSB- substance_P to the nicotinic acetylcholine receptor of Torpedo electroplaque .
7514262	0	acetylcholine	39,52	substance_P	100,111	acetylcholine	substance P	MESH:D000109	735077(Tax:8355)	Chemical	Gene	receptors|compound|START_ENTITY subunit|nmod|receptors determinant|nsubj|subunit determinant|nmod|affinity affinity|nmod|inhibition inhibition|compound|END_ENTITY	The beta subunit of neuronal nicotinic acetylcholine receptors is a determinant of the affinity for substance_P inhibition .
7524340	0	acetylcholine	47,60	substance_P	11,22	acetylcholine	substance P	MESH:D000109	281512(Tax:9913)	Chemical	Gene	Effects|acl|START_ENTITY Effects|nmod|END_ENTITY	Effects of substance_P on adrenal responses to acetylcholine in conscious calves .
7684070	0	acetylcholine	67,80	substance_P	11,22	acetylcholine	substance P	MESH:D000109	6863	Chemical	Gene	agonists|nmod|START_ENTITY binding|nmod|agonists receptor|amod|binding END_ENTITY|nmod|receptor	Effects of substance_P on the binding of agonists to the nicotinic acetylcholine receptor of Torpedo electroplaque .
8938661	0	acetylcholine	23,36	substance_P	71,82	acetylcholine	substance P	MESH:D000109	6863	Chemical	Gene	release|compound|START_ENTITY Modulation|nmod|release Modulation|dep|role role|nmod|interneurons interneurons|compound|END_ENTITY	Modulation of cortical acetylcholine release by serotonin : the role of substance_P interneurons .
9694912	0	acetylcholine	54,67	substance_P	108,119	acetylcholine	substance P	MESH:D000109	735077(Tax:8355)	Chemical	Gene	receptors|compound|START_ENTITY subunit|nmod|receptors domains|nmod|subunit contribute|nsubj|domains contribute|nmod|affinity affinity|nmod|END_ENTITY	Two domains of the beta subunit of neuronal nicotinic acetylcholine receptors contribute to the affinity of substance_P .
1639122	0	acetylcholine	11,24	thyrotropin-releasing_hormone	43,72	acetylcholine	thyrotropin-releasing hormone	MESH:D000109	25569(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|release release|nmod|END_ENTITY	Effects of acetylcholine on the release of thyrotropin-releasing_hormone from the rat retina in vitro .
2494104	0	acetylcholine	11,24	thyrotropin-releasing_hormone	28,57	acetylcholine	thyrotropin-releasing hormone	MESH:D000109	25569(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|release release|amod|END_ENTITY	Effects of acetylcholine on thyrotropin-releasing_hormone release from the rat caecum in vitro .
7965809	0	acetylcholine	67,80	thyrotropin-releasing_hormone	18,47	acetylcholine	thyrotropin-releasing hormone	MESH:D000109	25569(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY Effect|nmod|release Effect|nmod|NS-3 NS-3|appos|analog analog|amod|END_ENTITY	Effect of NS-3 , a thyrotropin-releasing_hormone analog , on in vivo acetylcholine release in rat brain : regional differences and its sites of action .
8472746	0	acetylcholine	86,99	thyrotropin-releasing_hormone	19,48	acetylcholine	thyrotropin-releasing hormone	MESH:D000109	25569(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|analogue analogue|amod|END_ENTITY	Effects of a novel thyrotropin-releasing_hormone analogue , JTP-2942 , on extracellular acetylcholine and choline levels in the rat frontal cortex and hippocampus .
8780015	0	acetylcholine	42,55	thyrotropin-releasing_hormone	96,125	acetylcholine	thyrotropin-releasing hormone	MESH:D000109	25569(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY release|nmod|hippocampus hippocampus|acl|induced induced|nmod|NS-3 NS-3|amod|END_ENTITY	Protein kinases are involved in prolonged acetylcholine release from rat hippocampus induced by thyrotropin-releasing_hormone analogue NS-3 .
8835640	0	acetylcholine	76,89	thyrotropin-releasing_hormone	27,56	acetylcholine	thyrotropin-releasing hormone	MESH:D000109	25569(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|TA-0910 TA-0910|appos|analog analog|amod|END_ENTITY	Effect of TA-0910 , a novel thyrotropin-releasing_hormone analog , on in vivo acetylcholine release and turnover in rat brain .
1901593	0	acetylcholine	93,106	thyrotropin_releasing_hormone	17,46	acetylcholine	thyrotropin releasing hormone	MESH:D000109	25569(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY analogue|nmod|release analogue|compound|END_ENTITY	Effects of a new thyrotropin_releasing_hormone analogue , YM-14673 , on the in vivo release of acetylcholine as measured by intracerebral dialysis in rats .
1901747	0	acetylcholine	49,62	thyrotropin_releasing_hormone	10,39	acetylcholine	thyrotropin releasing hormone	MESH:D000109	25569(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY END_ENTITY|nmod|release	Effect of thyrotropin_releasing_hormone -LRB- TRH -RRB- on acetylcholine release from different brain areas investigated by microdialysis .
3653040	0	acetylcholine	48,61	vasoactive_intestinal_polypeptide	11,44	acetylcholine	vasoactive intestinal polypeptide	MESH:D000109	117064(Tax:10116)	Chemical	Gene	stimulation|amod|START_ENTITY Effects|nmod|stimulation Effects|nmod|END_ENTITY	Effects of vasoactive_intestinal_polypeptide on acetylcholine stimulation of rat submandibular gland .
20202084	0	acetylcholine	19,32	vesicular_acetylcholine_transporter	68,103	acetylcholine	vesicular acetylcholine transporter	MESH:D000109	20508(Tax:10090)	Chemical	Gene	release|nmod|START_ENTITY release|nmod|END_ENTITY	Quantal release of acetylcholine in mice with reduced levels of the vesicular_acetylcholine_transporter .
8910293	0	acetylcholine	20,33	vesicular_acetylcholine_transporter	47,82	acetylcholine	vesicular acetylcholine transporter	MESH:D000109	6572	Chemical	Gene	transport|nmod|START_ENTITY transport|nmod|END_ENTITY	Active transport of acetylcholine by the human vesicular_acetylcholine_transporter .
14646164	0	acetylleucine_chloromethyl_ketone	77,110	glyceraldehyde-3-phosphate_dehydrogenase	25,65	acetylleucine chloromethyl ketone	glyceraldehyde-3-phosphate dehydrogenase	null	2597	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Conformational change of glyceraldehyde-3-phosphate_dehydrogenase induced by acetylleucine_chloromethyl_ketone is followed by unique enzymatic degradation .
10400014	0	acetylsalicylate	10,26	bradykinin	112,122	acetylsalicylate	bradykinin	CHEBI:15365	3827	Chemical	Gene	Effect|nmod|START_ENTITY induced|nsubj|Effect induced|nmod|infusion infusion|nmod|END_ENTITY	Effect of acetylsalicylate on cardiac and muscular_pain induced by intracoronary and intra-arterial infusion of bradykinin in humans .
26699907	0	acetylsalicylic_acid	16,36	ERK	40,43	acetylsalicylic acid	ERK	MESH:D001241	5594	Chemical	Gene	START_ENTITY|nmod|signaling signaling|compound|END_ENTITY	Dual effects of acetylsalicylic_acid on ERK signaling and Mitf transcription lead to inhibition of melanogenesis .
15158979	0	acetylsalicylic_acid	60,80	TGF-alpha	22,31	acetylsalicylic acid	TGF-alpha	MESH:D001241	24827(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|effect effect|nmod|END_ENTITY	The healing effect of TGF-alpha on gastric ulcer induced by acetylsalicylic_acid in rats .
15379866	0	acetylsalicylic_acid	43,63	cyclooxygenase-2	121,137	acetylsalicylic acid	cyclooxygenase-2	MESH:D001241	5743	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|role role|nmod|inhibition inhibition|amod|END_ENTITY	Dose-dependent immunomodulatory effects of acetylsalicylic_acid and indomethacin in human whole blood : potential role of cyclooxygenase-2 inhibition .
8571407	0	acetylsalicylic_acid	51,71	cytochrome_P4502E1	21,39	acetylsalicylic acid	cytochrome P4502E1	MESH:D001241	25086(Tax:10116)	Chemical	Gene	rats|nmod|START_ENTITY Induction|nmod|rats Induction|nmod|END_ENTITY	Induction of hepatic cytochrome_P4502E1 in rats by acetylsalicylic_acid or sodium_salicylate .
6642786	0	acetylsalicylic_acid	14,34	growth_hormone	64,78	acetylsalicylic acid	growth hormone	MESH:D001241	2688	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of acetylsalicylic_acid and diclofenac on stimulated growth_hormone and prolactin secretion in humans .
834152	0	acetylsalicylic_acid	11,31	growth_hormone	52,66	acetylsalicylic acid	growth hormone	MESH:D001241	2688	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|amod|END_ENTITY	Effects of acetylsalicylic_acid and indomethacin on growth_hormone secretion in man .
6757082	0	acetylsalicylic_acid	59,79	insulin	83,90	acetylsalicylic acid	insulin	MESH:D001241	3630	Chemical	Gene	START_ENTITY|nmod|response response|compound|END_ENTITY	Discrepant effect of the prostaglandin synthesis inhibitor acetylsalicylic_acid on insulin and C-peptide response to glucose in man .
6763430	0	acetylsalicylic_acid	10,30	insulin	34,41	acetylsalicylic acid	insulin	MESH:D001241	3630	Chemical	Gene	START_ENTITY|nmod|sensitivity sensitivity|compound|END_ENTITY	Effect of acetylsalicylic_acid on insulin sensitivity in subjects with impaired_glucose_tolerance .
18982014	0	acetylsalicylic_acid	9,29	interleukin-6	56,69	acetylsalicylic acid	interleukin-6	MESH:D001241	16193(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|nmod|END_ENTITY	Low-dose acetylsalicylic_acid inhibits the secretion of interleukin-6 from white_adipose_tissue .
16116334	0	acetylsalicylic_acid	10,30	nuclear_factor-kappaB	34,55	acetylsalicylic acid	nuclear factor-kappaB	MESH:D001241	4790	Chemical	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Effect of acetylsalicylic_acid on nuclear_factor-kappaB activation and on late preconditioning against infarction in the myocardium .
2358373	0	acetylsalicylic_acid	15,35	phosphoenolpyruvate_carboxykinase	39,72	acetylsalicylic acid	phosphoenolpyruvate carboxykinase	MESH:D001241	362282(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	The effects of acetylsalicylic_acid on phosphoenolpyruvate_carboxykinase activity and acinar heterotopy in livers from juvenile and adult rats .
18175938	0	acetylsalicylic_acid	44,64	tyrosinase	19,29	acetylsalicylic acid	tyrosinase	MESH:D001241	22173(Tax:10090)	Chemical	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|nmod|expression expression|amod|END_ENTITY	Down-regulation of tyrosinase expression by acetylsalicylic_acid in murine B16 melanoma .
18974607	0	aciclovir	44,53	ALDH2	13,18	aciclovir	ALDH2	MESH:D000212	217	Chemical	Gene	polymorphisms|nmod|START_ENTITY polymorphisms|nummod|END_ENTITY	Influence of ALDH2 genetic polymorphisms on aciclovir pharmacokinetics following oral administration of valaciclovir in Japanese end-stage_renal_disease patients .
7697001	0	acifluorfen	54,65	protoporphyrinogen_oxidase	24,50	acifluorfen	protoporphyrinogen oxidase	MESH:C018425	5498	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of mammalian protoporphyrinogen_oxidase by acifluorfen .
8606641	0	acipimox	11,19	GH	67,69	acipimox	GH	MESH:C027696	2688	Chemical	Gene	START_ENTITY|nmod|response response|appos|END_ENTITY	Effects of acipimox , an antilipolytic drug , on the growth_hormone -LRB- GH -RRB- response to GH-releasing_hormone alone or combined with arginine in obesity .
16803850	0	acipimox	25,33	growth_hormone	57,71	acipimox	growth hormone	MESH:C027696	81668(Tax:10116)	Chemical	Gene	therapy|nmod|START_ENTITY enhances|nsubj|therapy enhances|dobj|effect effect|nmod|treatment treatment|amod|END_ENTITY	Combination therapy with acipimox enhances the effect of growth_hormone treatment on linear body growth in the normal and small-for-gestational-age rat .
8606641	0	acipimox	11,19	growth_hormone	51,65	acipimox	growth hormone	MESH:C027696	2688	Chemical	Gene	START_ENTITY|nmod|response response|amod|END_ENTITY	Effects of acipimox , an antilipolytic drug , on the growth_hormone -LRB- GH -RRB- response to GH-releasing_hormone alone or combined with arginine in obesity .
1982767	0	acivicin	14,22	gamma-glutamyl_transpeptidase	40,69	acivicin	gamma-glutamyl transpeptidase	MESH:C006303	14598(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	The effect of acivicin , an inhibitor of gamma-glutamyl_transpeptidase on mouse molar development in vitro .
7954424	0	acivicin	56,64	gamma-glutamyl_transpeptidase	14,43	acivicin	gamma-glutamyl transpeptidase	MESH:C006303	116568(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Inhibition of gamma-glutamyl_transpeptidase activity by acivicin in vivo protects the kidney from cisplatin-induced toxicity .
15469854	0	acivicin	158,166	gamma-glutamyltranspeptidase	81,109	acivicin	gamma-glutamyltranspeptidase	MESH:C006303	92086	Chemical	Gene	inhibition|compound|START_ENTITY revealed|nmod|inhibition revealed|nmod|inhibition inhibition|nmod|END_ENTITY	High glutathione turnover in human cell lines revealed by acivicin inhibition of gamma-glutamyltranspeptidase and the effects of thiol-reactive metals during acivicin inhibition .
15469854	0	acivicin	58,66	gamma-glutamyltranspeptidase	81,109	acivicin	gamma-glutamyltranspeptidase	MESH:C006303	92086	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	High glutathione turnover in human cell lines revealed by acivicin inhibition of gamma-glutamyltranspeptidase and the effects of thiol-reactive metals during acivicin inhibition .
16216418	0	acivicin	123,131	gamma-glutamyltranspeptidase	146,174	acivicin	gamma-glutamyltranspeptidase	MESH:C006303	92086	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	Glutathione turnover in human cell lines in the presence of agents with glutathione influencing potential with and without acivicin inhibition of gamma-glutamyltranspeptidase .
2857721	0	acivicin	7,15	gamma-glutamyltranspeptidase	81,109	acivicin	gamma-glutamyltranspeptidase	MESH:C006303	116568(Tax:10116)	Chemical	Gene	Use|nmod|START_ENTITY constants|nsubj|Use constants|nmod|turnover turnover|nmod|END_ENTITY	Use of acivicin in the determination of rate constants for turnover of rat renal gamma-glutamyltranspeptidase .
2859259	0	acivicin	64,72	gamma-glutamyltranspeptidase	24,52	acivicin	gamma-glutamyltranspeptidase	MESH:C006303	116568(Tax:10116)	Chemical	Gene	Effect|appos|START_ENTITY Effect|nmod|inhibition inhibition|nmod|END_ENTITY	Effect of inhibition of gamma-glutamyltranspeptidase by AT-125 -LRB- acivicin -RRB- on glutathione and cysteine levels in rat brain and plasma .
26682939	0	acotiamide	16,26	acetylcholinesterase	45,65	acotiamide	acetylcholinesterase	MESH:C410959	83817(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Distribution of acotiamide , an orally active acetylcholinesterase inhibitor , into the myenteric plexus of rat and dog stomachs .
17209120	0	acridine	26,34	DNA_topoisomerase_IIbeta	65,89	acridine	DNA topoisomerase IIbeta	CHEBI:36420	7155	Chemical	Gene	mutations|amod|START_ENTITY mutations|nmod|END_ENTITY	Differential selection of acridine resistance mutations in human DNA_topoisomerase_IIbeta is dependent on the acridine structure .
18206177	0	acrolein	38,46	Antithrombin	0,12	acrolein	Antithrombin	MESH:D000171	462	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|activity activity|compound|END_ENTITY	Antithrombin activity is inhibited by acrolein and homocysteine_thiolactone : Protection by cysteine .
17318410	0	acrolein	22,30	COX-2	13,18	acrolein	COX-2	MESH:D000171	29527(Tax:10116)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of COX-2 by acrolein in rat lung epithelial cells .
18234483	0	acrolein	33,41	COX-2	13,18	acrolein	COX-2	MESH:D000171	29527(Tax:10116)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|expression expression|compound|END_ENTITY	Induction of COX-2 expression by acrolein in the rat model of hemorrhagic_cystitis .
18201443	0	acrolein	30,38	IL-8	91,95	acrolein	IL-8	MESH:D000171	3576	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	The cigarette smoke component acrolein inhibits expression of the innate immune components IL-8 and human_beta-defensin_2 by sinonasal epithelial cells .
9884322	0	acrolein	98,106	aldehyde_dehydrogenase_1	20,44	acrolein	aldehyde dehydrogenase 1	MESH:D000171	216	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of human aldehyde_dehydrogenase_1 by the 4-hydroxycyclophosphamide degradation product acrolein .
19729010	0	acrolein	11,19	antithrombin	79,91	acrolein	antithrombin	MESH:D000171	11905(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of acrolein , a natural occurring aldehyde , on the anticoagulant serpin antithrombin .
16195596	0	acrolein	23,31	apolipoprotein_e	100,116	acrolein	apolipoprotein e	MESH:D000171	348	Chemical	Gene	modification|compound|START_ENTITY Effect|nmod|modification Effect|nmod|END_ENTITY	Effect of ascorbate on acrolein modification of very low density lipoprotein and uptake of oxidized apolipoprotein_e by hepatocytes .
16337876	0	acrolein	45,53	c-jun	27,32	acrolein	c-jun	MESH:D000171	3725	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of c-jun and CREB by acrolein and 4-hydroxynonenal .
2501305	0	acrolein	52,60	carbonic_anhydrase_II	25,46	acrolein	carbonic anhydrase II	MESH:D000171	760	Chemical	Gene	modification|nmod|START_ENTITY modification|nmod|END_ENTITY	Chemical modification of carbonic_anhydrase_II with acrolein .
8212054	0	acrolein	89,97	glucose-6-phosphate_dehydrogenase	25,58	acrolein	glucose-6-phosphate dehydrogenase	MESH:D000171	2539	Chemical	Gene	cells|nmod|START_ENTITY cells|amod|END_ENTITY	In vitro inactivation of glucose-6-phosphate_dehydrogenase from human red blood cells by acrolein : a possible biomarker of exposure .
16480751	0	acrolein	129,137	heme_oxygenase-1	28,44	acrolein	heme oxygenase-1	MESH:D000171	3162	Chemical	Gene	concentrations|nmod|START_ENTITY Upregulation|nmod|concentrations Upregulation|nmod|expression expression|amod|END_ENTITY	Upregulation of endothelial heme_oxygenase-1 expression through the activation of the JNK pathway by sublethal concentrations of acrolein .
21812108	0	acrolein	15,23	thioredoxin	31,42	acrolein	thioredoxin	MESH:D000171	7295	Chemical	Gene	START_ENTITY|nmod|system system|compound|END_ENTITY	The effects of acrolein on the thioredoxin system : implications for redox-sensitive signaling .
15652504	0	acrolein	62,70	thioredoxin_reductase	13,34	acrolein	thioredoxin reductase	MESH:D000171	25824	Chemical	Gene	response|acl|START_ENTITY END_ENTITY|nmod|response	Induction of thioredoxin_reductase as an adaptive response to acrolein in human umbilical vein endothelial cells .
16141435	0	acrylamide	37,47	CYP2E1	8,14	acrylamide	CYP2E1	MESH:D020106	13106(Tax:10090)	Chemical	Gene	epoxidation|nmod|START_ENTITY Role|nmod|epoxidation Role|nmod|END_ENTITY	Role of CYP2E1 in the epoxidation of acrylamide to glycidamide and formation of DNA and hemoglobin adducts .
17660004	0	acrylamide	37,47	CYP2E1	97,103	acrylamide	CYP2E1	MESH:D020106	1571	Chemical	Gene	genotoxicity|nmod|START_ENTITY enhanced|dobj|genotoxicity enhanced|nmod|induction induction|nummod|END_ENTITY	Ethanol enhanced the genotoxicity of acrylamide in human , metabolically competent HepG2 cells by CYP2E1 induction and glutathione depletion .
18418580	0	acrylamide	56,66	CYP2E1	6,12	acrylamide	CYP2E1	MESH:D020106	1571	Chemical	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Human CYP2E1 mediates the formation of glycidamide from acrylamide .
21402133	0	acrylamide	115,125	CYP2E1	15,21	acrylamide	CYP2E1	MESH:D020106	1571	Chemical	Gene	exposed|xcomp|START_ENTITY workers|acl|exposed GST|nmod|workers GST|nsubj|Association Association|nmod|END_ENTITY	Association of CYP2E1 , GST and mEH genetic polymorphisms with urinary acrylamide metabolites in workers exposed to acrylamide .
21402133	0	acrylamide	70,80	CYP2E1	15,21	acrylamide	CYP2E1	MESH:D020106	1571	Chemical	Gene	metabolites|amod|START_ENTITY polymorphisms|nmod|metabolites GST|dobj|polymorphisms GST|nsubj|Association Association|nmod|END_ENTITY	Association of CYP2E1 , GST and mEH genetic polymorphisms with urinary acrylamide metabolites in workers exposed to acrylamide .
23069881	0	acrylamide	146,156	CYP2E1	24,30	acrylamide	CYP2E1	MESH:D020106	1571	Chemical	Gene	exposed|xcomp|START_ENTITY workers|acl|exposed genotypes|nmod|workers genotypes|nsubj|effect effect|nmod|END_ENTITY	The modifying effect of CYP2E1 , GST , and mEH genotypes on the formation of hemoglobin adducts of acrylamide and glycidamide in workers exposed to acrylamide .
23069881	0	acrylamide	97,107	CYP2E1	24,30	acrylamide	CYP2E1	MESH:D020106	1571	Chemical	Gene	adducts|nmod|START_ENTITY formation|nmod|adducts genotypes|nmod|formation genotypes|nsubj|effect effect|nmod|END_ENTITY	The modifying effect of CYP2E1 , GST , and mEH genotypes on the formation of hemoglobin adducts of acrylamide and glycidamide in workers exposed to acrylamide .
24398672	0	acrylamide	8,18	KRAS	87,91	acrylamide	KRAS	MESH:D020106	3845	Chemical	Gene	START_ENTITY|nmod|mutations mutations|nmod|END_ENTITY	Dietary acrylamide intake and the risk of colorectal_cancer with specific mutations in KRAS and APC .
8507302	0	acrylamide	10,20	MAP1	77,81	acrylamide	MAP1	MESH:D020106	369036(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of acrylamide on the distribution of microtubule-associated proteins -LRB- MAP1 and MAP2 -RRB- in selected regions of rat brain .
1892836	0	acrylamide	70,80	P450C-21	58,66	acrylamide	P450C-21	MESH:D020106	281741(Tax:9913)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of substrate binding to the adrenal cytochrome P450C-21 by acrylamide and its implications for solvent accessibility of the binding site in the microsomes .
16337756	0	acrylamide	94,104	cytochrome_P450_2E1	47,66	acrylamide	cytochrome P450 2E1	MESH:D020106	1571	Chemical	Gene	bioactivation|nmod|START_ENTITY bioactivation|amod|END_ENTITY	The garlic ingredient diallyl_sulfide inhibits cytochrome_P450_2E1 dependent bioactivation of acrylamide to glycidamide .
19190172	0	acrylamide	79,89	cytochrome_P450_2E1	16,35	acrylamide	cytochrome P450 2E1	MESH:D020106	1571	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	In vivo role of cytochrome_P450_2E1 and glutathione-S-transferase activity for acrylamide toxicokinetics in humans .
1346962	0	acrylamide	42,52	factor_XIIIa	26,38	acrylamide	factor XIIIa	MESH:D020106	2162	Chemical	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of placental factor_XIIIa by acrylamide .
2367567	0	acrylamide	19,29	glyceraldehyde-3-phosphate_dehydrogenase	35,75	acrylamide	glyceraldehyde-3-phosphate dehydrogenase	MESH:D020106	100009074(Tax:9986)	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	The interaction of acrylamide with glyceraldehyde-3-phosphate_dehydrogenase .
4047509	0	acrylamide	80,90	glyceraldehyde-3-phosphate_dehydrogenase	14,54	acrylamide	glyceraldehyde-3-phosphate dehydrogenase	MESH:D020106	24383(Tax:10116)	Chemical	Gene	compounds|amod|START_ENTITY rat|nmod|compounds tissues|nmod|rat Inhibition|nmod|tissues Inhibition|nmod|END_ENTITY	Inhibition of glyceraldehyde-3-phosphate_dehydrogenase in tissues of the rat by acrylamide and related compounds .
7898611	0	acrylamide	109,119	glyceraldehyde-3-phosphate_dehydrogenase	15,55	acrylamide	glyceraldehyde-3-phosphate dehydrogenase	MESH:D020106	24383(Tax:10116)	Chemical	Gene	synaptosomes|nmod|START_ENTITY synaptosomes|nsubj|Attenuation Attenuation|nmod|activity activity|amod|END_ENTITY	Attenuation of glyceraldehyde-3-phosphate_dehydrogenase activity and ATP levels in rat brain synaptosomes by acrylamide .
2400913	0	acrylamide	14,24	ornithine_decarboxylase	45,68	acrylamide	ornithine decarboxylase	MESH:D020106	24609(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|induction induction|nmod|END_ENTITY	The effect of acrylamide on the induction of ornithine_decarboxylase in the dorsal root ganglion of the rat .
12031331	0	acrylamides	42,53	factor_Xa	57,66	acrylamides	factor Xa	MESH:D000178	2159	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Design , synthesis , and SAR of substituted acrylamides as factor_Xa inhibitors .
12113838	0	acrylamides	12,23	factor_Xa	27,36	acrylamides	factor Xa	MESH:D000178	2159	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Substituted acrylamides as factor_Xa inhibitors : improving bioavailability by P1 modification .
22996190	0	acrylate	36,44	CO2	50,53	acrylate	CO2	MESH:C036658	717	Chemical	Gene	synthesis|nmod|START_ENTITY synthesis|nmod|END_ENTITY	The first catalytic synthesis of an acrylate from CO2 and an alkene-a rational approach .
23057331	0	acrylonitrile	11,24	Bcl-2	46,51	acrylonitrile	Bcl-2	MESH:D000181	12043(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of acrylonitrile on the expression of Bcl-2 and Bax in spermatogenic cell of mice -RSB- .
4160677	0	actinomycin_C	10,23	glucose-6-phosphate_dehydrogenase	27,60	actinomycin C	glucose-6-phosphate dehydrogenase	MESH:C030013	2539	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effect of actinomycin_C on glucose-6-phosphate_dehydrogenase activity of a human adenocarcinoma growing in a heterologous host .
7908518	0	actinomycin_D	85,98	DNA_binding_protein	17,36	actinomycin D	DNA binding protein	MESH:D003609	284390	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of a DNA_binding_protein , MDR-NF1 / YB-1 , in human MDR1 gene expression by actinomycin_D .
1720008	0	actinomycin_D	11,24	IGF-I	67,72	actinomycin D	IGF-I	MESH:D003609	3479	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of actinomycin_D and cycloheximide on transcript levels of IGF-I , actin , and albumin in hepatocyte primary cultures treated with growth hormone and insulin .
9389502	10	actinomycin_D	1834,1847	IGF-I	1811,1816	actinomycin D	IGF-I	MESH:D003609	3479	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|Induction Induction|nmod|expression expression|nmod|END_ENTITY	It preceded the maximal expression of NaPi transport stimulation -LRB- 173-235 % of control -RRB- , which was observed after 18-24 h. Induction of Glvr-1 mRNA expression by IGF-I was inhibited by actinomycin_D , suggesting that this effect was related to an increase in gene transcription .
15111130	0	actinomycin_D	47,60	Protein_kinase_B	0,16	actinomycin D	Protein kinase B	MESH:D003609	2185	Chemical	Gene	induced|nmod|START_ENTITY apoptosis|acl|induced inhibits|dobj|apoptosis inhibits|nsubj|END_ENTITY	Protein_kinase_B inhibits apoptosis induced by actinomycin_D in ECV304 cells through phosphorylation of caspase_8 .
2579168	0	actinomycin_D	10,23	SS-B/La	61,68	actinomycin D	SS-B/La	MESH:D003609	6741	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	Effect of actinomycin_D on the expression of nuclear antigen SS-B/La .
17197095	0	actinomycin_D	115,128	TNFalpha	87,95	actinomycin D	TNFalpha	MESH:D003609	21926(Tax:10090)	Chemical	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	Focal_adhesion_kinase determines the fate of death or survival of cells in response to TNFalpha in the presence of actinomycin_D .
19236112	0	actinomycin_D	15,28	c-Met	107,112	actinomycin D	c-Met	MESH:D003609	4233	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Interaction of actinomycin_D with promoter element of c-met and its inhibitory effect on the expression of c-Met .
9719487	0	actinomycin_D	33,46	leptin	15,21	actinomycin D	leptin	MESH:D003609	25608(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|Stimulation Stimulation|nmod|END_ENTITY	Stimulation of leptin release by actinomycin_D in rat adipocytes .
435519	0	actinomycin_D	97,110	lipase	23,29	actinomycin D	lipase	MESH:D003609	291437(Tax:10116)	Chemical	Gene	Increase|nmod|START_ENTITY Increase|nmod|END_ENTITY	Increase in liver acid lipase of thyroidectomized rats by thyroid hormones and its inhibition by actinomycin_D .
19657224	0	actinomycin_D	51,64	p53	27,30	actinomycin D	p53	MESH:D003609	7157	Chemical	Gene	pathway|nmod|START_ENTITY pathway|compound|END_ENTITY	Specific activation of the p53 pathway by low dose actinomycin_D : a new route to p53 based cyclotherapy .
407111	0	actinomycin_D	11,24	prolactin	43,52	actinomycin D	prolactin	MESH:D003609	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	Effects of actinomycin_D on the release of prolactin and growth hormone from rat pituitaries in vitro by thyrotropin releasing hormone .
5326625	0	actinomycin_D	11,24	renin	52,57	actinomycin D	renin	MESH:D003609	24715(Tax:10116)	Chemical	Gene	Action|nmod|START_ENTITY Action|nmod|END_ENTITY	-LSB- Action of actinomycin_D and puromycin on the renal renin of the rat -RSB- .
26645890	0	actinomycin_X2	59,73	mTOR	86,90	actinomycin X2	mTOR	null	21977(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nmod|END_ENTITY	Apoptosis of human prostate_cancer cells induced by marine actinomycin_X2 through the mTOR pathway compounded by MiRNA144 .
3365269	0	actinonin	37,46	aminopeptidase	11,25	actinonin	aminopeptidase	MESH:C010531	10404	Chemical	Gene	inhibitors|dobj|START_ENTITY inhibitors|nsubj|Effects Effects|nmod|END_ENTITY	Effects of aminopeptidase inhibitors actinonin and amastatin on chemotactic and phagocytic responses of human neutrophils .
15117880	0	activin_a	16,25	vascular_endothelial_growth_factor	75,109	activin a	vascular endothelial growth factor	null	281572(Tax:9913)	Chemical	Gene	role|nmod|START_ENTITY induced|nsubj|role induced|nmod|END_ENTITY	Crucial role of activin_a in tubulogenesis of endothelial cells induced by vascular_endothelial_growth_factor .
137809	0	actomyosin	14,24	ATPase	25,31	actomyosin	ATPase	null	1769	Chemical	Gene	Inhibition|nmod|START_ENTITY END_ENTITY|nsubj|Inhibition	Inhibition of actomyosin ATPase by high concentrations of 5-hydroxytryptamine .
1531959	0	actomyosin	79,89	ATPase	90,96	actomyosin	ATPase	null	1769	Chemical	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	The importance of C-terminal amino_acid residues of actin to the inhibition of actomyosin ATPase activity by caldesmon and troponin I. Proteolytic elimination of three C-terminal amino_acid residues from actin weakens its interaction with caldesmon and troponin I and , in consequence , lowers the inhibitory effects of both proteins on actomyosin ATPase activity .
3155681	0	actomyosin	53,63	ATPase	64,70	actomyosin	ATPase	null	1769	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Effect of the filamentous structure of myosin on the actomyosin ATPase activity .
6459580	0	actomyosin	14,24	ATPase	25,31	actomyosin	ATPase	null	1769	Chemical	Gene	Inhibition|nmod|START_ENTITY END_ENTITY|nsubj|Inhibition	Inhibition of actomyosin ATPase by vanadate .
8245035	0	actomyosin	35,45	ATPase	46,52	actomyosin	ATPase	null	1769	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Goniodomin_A induces modulation of actomyosin ATPase activity mediated through conformational change of actin .
8755998	0	actomyosin	8,18	ATPase	19,25	actomyosin	ATPase	null	1769	Chemical	Gene	START_ENTITY|dep|activity activity|amod|END_ENTITY	Maximal actomyosin ATPase activity and in vitro_myosin_motility are unaltered in human mitral_regurgitation heart failure .
9338443	0	actomyosin	26,36	ATPase	37,43	actomyosin	ATPase	null	100009279(Tax:9986)	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Skeletal muscle force and actomyosin ATPase activity reduced by nitric_oxide donor .
3159750	0	actomyosin	26,36	filamin	15,22	actomyosin	filamin	null	2318	Chemical	Gene	activity|amod|START_ENTITY effect|nmod|activity effect|nmod|END_ENTITY	Dual effect of filamin on actomyosin ATPase activity .
2535028	0	actomyosin	75,85	myosin	27,33	actomyosin	myosin	null	79784	Chemical	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Effects of skeletal muscle myosin light chain phosphorylation on synthetic actomyosin ATPase activity and superprecipitation .
9760179	0	actophorin	162,172	ADF	133,136	actophorin	ADF	null	2934	Chemical	Gene	START_ENTITY|amod|binding binding|nmod|END_ENTITY	The effect of two actin_depolymerizing_factors -LRB- ADF/cofilins -RRB- on actin filament turnover : pH sensitivity of F-actin binding by human ADF , but not of Acanthamoeba actophorin .
20021825	0	actovegin	11,20	bcl-2	60,65	actovegin	bcl-2	MESH:C015646	24224(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of actovegin on intestinal mucosa and expression of bcl-2 / bax genes in rats with acute_radiation_enteritis -RSB- .
1711115	0	acyclic_retinoid	21,37	alpha-fetoprotein	77,94	acyclic retinoid	alpha-fetoprotein	MESH:C034534	24177(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|nmod|END_ENTITY	Inhibitory effect of acyclic_retinoid -LRB- polyprenoic_acid -RRB- on the secretion of alpha-fetoprotein in CCl4-treated rats .
21214951	0	acyclic_retinoid	73,89	caspase_3	18,27	acyclic retinoid	caspase 3	MESH:C034534	836	Chemical	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	Dual induction of caspase_3 - and transglutaminase-dependent apoptosis by acyclic_retinoid in hepatocellular_carcinoma cells .
11437362	0	acyclo-retinoic_acid	11,31	retinoic_acid_receptor	66,88	acyclo-retinoic acid	retinoic acid receptor	MESH:C431913	5914	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of acyclo-retinoic_acid and lycopene on activation of the retinoic_acid_receptor and proliferation of mammary cancer cells .
8274720	0	acyclovir	67,76	alpha-2a-interferon	40,59	acyclovir	alpha-2a-interferon	MESH:D000212	3440	Chemical	Gene	therapy|compound|START_ENTITY END_ENTITY|nmod|therapy	Treatment of herpes_zoster : recombinant alpha-2a-interferon versus acyclovir and vitamin therapy .
6639669	0	acyclovir	11,20	hypoxanthine-guanine_phosphoribosyltransferase	44,90	acyclovir	hypoxanthine-guanine phosphoribosyltransferase	MESH:D000212	3251	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of acyclovir and its metabolites on hypoxanthine-guanine_phosphoribosyltransferase .
1418778	0	acyclovir	56,65	p24	73,76	acyclovir	p24	MESH:D000212	10959	Chemical	Gene	START_ENTITY|nmod|antigenaemia antigenaemia|amod|END_ENTITY	The effect of treatment with zidovudine with or without acyclovir on HIV p24 antigenaemia in patients with AIDS or AIDS-related_complex .
16597827	0	acyl	34,38	Asl1650	22,29	acyl	Asl1650	null	1105242(Tax:103690)	Chemical	Gene	protein|amod|START_ENTITY END_ENTITY|appos|protein	Solution structure of Asl1650 , an acyl carrier protein from Anabaena_sp .
10234612	0	acyl	26,30	NDUFAB1	48,55	acyl	NDUFAB1	null	4706	Chemical	Gene	subunit|amod|START_ENTITY subunit|appos|END_ENTITY	The human nuclear-encoded acyl carrier subunit -LRB- NDUFAB1 -RRB- of the mitochondrial complex I in human pathology .
24368161	0	acyl	6,10	O-3	20,23	acyl	O-3	null	28879	Chemical	Gene	group|amod|START_ENTITY group|nmod|END_ENTITY	Is an acyl group at O-3 in glucosyl donors able to control a-stereoselectivity of glycosylation ?
19118366	0	acyl	20,24	SMb20651	0,8	acyl	SMb20651	null	1237691(Tax:266834)	Chemical	Gene	protein|amod|START_ENTITY protein|nsubj|END_ENTITY	SMb20651 is another acyl carrier protein from Sinorhizobium_meliloti .
19797355	0	acyl	22,26	SMc01553	0,8	acyl	SMc01553	null	1233970(Tax:266834)	Chemical	Gene	protein|amod|START_ENTITY protein|nsubj|END_ENTITY	SMc01553 is the sixth acyl carrier protein in Sinorhizobium_meliloti_1021 .
16176589	0	acyl	42,46	cholesterol_esterase	63,83	acyl	cholesterol esterase	null	1056	Chemical	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Probing stereoselective inhibition of the acyl binding site of cholesterol_esterase with four diastereomers of 2 ' - N-alpha-methylbenzylcarbamyl-1 , _ 1 ' - bi-2-naphthol .
15677766	0	acyl	64,68	ghrelin	85,92	acyl	ghrelin	null	58991(Tax:10090)	Chemical	Gene	modification|amod|START_ENTITY modification|nmod|END_ENTITY	Ingested medium-chain_fatty_acids are directly utilized for the acyl modification of ghrelin .
20542063	0	acyl	54,58	ghrelin	59,66	acyl	ghrelin	null	59301(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|concentrations concentrations|compound|END_ENTITY	The effect of exercise intensity on plasma and tissue acyl ghrelin concentrations in fasted rats .
7971711	0	acyl	13,17	insulin	33,40	acyl	insulin	null	3630	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Stability of acyl derivatives of insulin in the small intestine : relative importance of insulin association characteristics in aqueous solution .
7759115	0	acyl-CoA	37,45	ACADSB	61,67	acyl-CoA	ACADSB	MESH:D000214	36	Chemical	Gene	dehydrogenase|compound|START_ENTITY Localization|nmod|dehydrogenase Localization|appos|END_ENTITY	Localization of short/branched chain acyl-CoA dehydrogenase -LRB- ACADSB -RRB- to human chromosome 10 .
10196189	0	acyl-CoA	6,14	ACAT-1	46,52	acyl-CoA	ACAT-1	MESH:D000214	38	Chemical	Gene	START_ENTITY|dep|gene gene|appos|END_ENTITY	Human acyl-CoA : cholesterol_acyltransferase-1 -LRB- ACAT-1 -RRB- gene organization and evidence that the 4.3-kilobase ACAT-1 mRNA is produced from two different chromosomes .
11342056	7	acyl-CoA	1242,1250	ACBP	1144,1148	acyl-CoA	ACBP	MESH:D000214	1622	Chemical	Gene	amounts|amod|START_ENTITY store|dobj|amounts able|xcomp|store suggests|ccomp|able higher|advcl|suggests higher|nsubj|concentration concentration|compound|END_ENTITY	The fact that the ACBP concentration is higher than that of FABP suggests that the Harderian gland is able to store acyl-CoA amounts in ACBP larger than those of fatty_acids in H-FABP for 1-alkyl-2 ,3 - diacylglycerol synthesis .
16018771	0	acyl-CoA	17,25	ACBP	43,47	acyl-CoA	ACBP	MESH:D000214	1622	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Evolution of the acyl-CoA binding protein -LRB- ACBP -RRB- .
17044054	0	acyl-CoA	116,124	ACBP	74,78	acyl-CoA	ACBP	MESH:D000214	1622	Chemical	Gene	ligand|amod|START_ENTITY binding|nmod|ligand mode|nmod|binding reveal|dobj|mode reveal|nsubj|structures structures|nmod|END_ENTITY	High resolution crystal structures of unliganded and liganded human liver ACBP reveal a new mode of binding for the acyl-CoA ligand .
19505229	6	acyl-CoA	1081,1089	ACBP	1021,1025	acyl-CoA	ACBP	MESH:D000214	13167(Tax:10090)	Chemical	Gene	detect|dobj|START_ENTITY utilized|advcl|detect utilized|dobj|binding_protein binding_protein|appos|END_ENTITY	In this study , we utilized the acyl-coenzyme_A _ -LRB- CoA -RRB- _ binding_protein -LRB- ACBP -RRB- as a molecular probe to detect radioactive long-chain acyl-CoA , a direct product of Elovl6 .
19702754	0	acyl-CoA	92,100	ACBP	35,39	acyl-CoA	ACBP	MESH:D000214	106367157	Chemical	Gene	exchange|nmod|START_ENTITY enhances|dobj|exchange enhances|nsubj|acyl-CoA-binding_protein acyl-CoA-binding_protein|appos|END_ENTITY	A 10-kDa acyl-CoA-binding_protein -LRB- ACBP -RRB- from Brassica_napus enhances acyl exchange between acyl-CoA and phosphatidylcholine .
8166635	0	acyl-CoA	58,66	ACBP	26,30	acyl-CoA	ACBP	MESH:D000214	1622	Chemical	Gene	transport|amod|START_ENTITY mediate|dobj|transport mediate|nsubj|Acyl-CoA-binding_protein Acyl-CoA-binding_protein|appos|END_ENTITY	Acyl-CoA-binding_protein -LRB- ACBP -RRB- can mediate intermembrane acyl-CoA transport and donate_acyl-CoA for beta-oxidation and glycerolipid synthesis .
8318018	0	acyl-CoA	70,78	ACBP	41,45	acyl-CoA	ACBP	MESH:D000214	25045(Tax:10116)	Chemical	Gene	processes|nmod|START_ENTITY acyl-CoA_binding_protein|nmod|processes acyl-CoA_binding_protein|appos|END_ENTITY	Interaction of acyl-CoA_binding_protein -LRB- ACBP -RRB- on processes for which acyl-CoA is a substrate , product or inhibitor .
9219899	0	acyl-CoA	42,50	ACBP	26,30	acyl-CoA	ACBP	MESH:D000214	1622	Chemical	Gene	regulates|dobj|START_ENTITY regulates|nsubj|Acyl-CoA_binding_protein Acyl-CoA_binding_protein|appos|END_ENTITY	Acyl-CoA_binding_protein -LRB- ACBP -RRB- regulates acyl-CoA : cholesterol_acyltransferase -LRB- ACAT -RRB- in human mononuclear phagocytes .
20429931	0	acyl-CoA	16,24	ACSL6	36,41	acyl-CoA	ACSL6	MESH:D000214	23305	Chemical	Gene	isoforms|amod|START_ENTITY isoforms|compound|END_ENTITY	Activity of the acyl-CoA synthetase ACSL6 isoforms : role of the fatty_acid Gate-domains .
9219899	0	acyl-CoA	42,50	Acyl-CoA_binding_protein	0,24	acyl-CoA	Acyl-CoA binding protein	MESH:D000214	1622	Chemical	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Acyl-CoA_binding_protein -LRB- ACBP -RRB- regulates acyl-CoA : cholesterol_acyltransferase -LRB- ACAT -RRB- in human mononuclear phagocytes .
22189440	0	acyl-CoA	27,35	FAR6	47,51	acyl-CoA	FAR6	MESH:D000214	824837(Tax:3702)	Chemical	Gene	reductase|amod|START_ENTITY reductase|appos|END_ENTITY	Upstream sequence of fatty acyl-CoA reductase -LRB- FAR6 -RRB- of Arabidopsis_thaliana drives wound-inducible and stem-specific expression .
1805095	0	acyl-CoA	150,158	HMG-CoA_reductase	131,148	acyl-CoA	HMG-CoA reductase	MESH:D000214	25675(Tax:10116)	Chemical	Gene	acyltransferase|amod|START_ENTITY acyltransferase|amod|END_ENTITY	Effects of perturbations in hepatic free and esterified cholesterol pools on bile_acid synthesis , cholesterol_7_alpha-hydroxylase , HMG-CoA_reductase , acyl-CoA : cholesterol acyltransferase and cytosolic cholesteryl_ester hydrolase .
17277896	0	acyl-CoA	26,34	IBR3	0,4	acyl-CoA	IBR3	MESH:D000214	819865(Tax:3702)	Chemical	Gene	protein|amod|START_ENTITY END_ENTITY|appos|protein	IBR3 , a novel peroxisomal acyl-CoA dehydrogenase-like protein required for indole-3-butyric_acid response .
9353271	0	acyl-CoA	80,88	PPARalpha	109,118	acyl-CoA	PPARalpha	MESH:D000214	25747(Tax:10116)	Chemical	Gene	genes|amod|START_ENTITY genes|nmod|END_ENTITY	Coordinate regulation of the expression of the fatty_acid transport protein and acyl-CoA synthetase genes by PPARalpha and PPARgamma activators .
18980943	0	acyl-CoA	37,45	VLCAD	94,99	acyl-CoA	VLCAD	MESH:D000214	11370(Tax:10090)	Chemical	Gene	increase|nmod|START_ENTITY Corresponding|dobj|increase Corresponding|nmod|mice mice|amod|END_ENTITY	Corresponding increase in long-chain acyl-CoA and acylcarnitine after exercise in muscle from VLCAD mice .
20580297	0	acyl-CoA	99,107	VLCAD	123,128	acyl-CoA	VLCAD	MESH:D000214	11370(Tax:10090)	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	Medium-chain triglycerides impair lipid metabolism and induce hepatic_steatosis in very long-chain acyl-CoA dehydrogenase -LRB- VLCAD -RRB- - deficient mice .
23024820	0	acyl-CoA	50,58	VLCAD	84,89	acyl-CoA	VLCAD	MESH:D000214	11370(Tax:10090)	Chemical	Gene	mouse|amod|START_ENTITY mouse|dep|END_ENTITY	Tissue-specific strategies of the very-long chain acyl-CoA dehydrogenase-deficient -LRB- VLCAD - / - -RRB- mouse to compensate a defective fatty_acid b-oxidation .
25887160	0	acyl-CoA	57,65	VLCAD	91,96	acyl-CoA	VLCAD	MESH:D000214	11370(Tax:10090)	Chemical	Gene	deficient|amod|START_ENTITY deficient|dep|END_ENTITY	Sexual dimorphism of lipid metabolism in very long-chain acyl-CoA dehydrogenase deficient -LRB- VLCAD -LRB- - / - -RRB- -RRB- mice in response to medium-chain triglycerides -LRB- MCT -RRB- .
20111596	0	acyl-CoA	31,39	acs-20	58,64	acyl-CoA	acs-20	MESH:D000214	178190(Tax:6239)	Chemical	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Two very long chain fatty acid acyl-CoA synthetase genes , acs-20 and acs-22 , have roles in the cuticle surface barrier in Caenorhabditis_elegans .
10721891	0	acyl-CoA	36,44	acyl-CoA_binding_protein	8,32	acyl-CoA	acyl-CoA binding protein	MESH:D000214	1622	Chemical	Gene	metabolism|amod|START_ENTITY Role|nmod|metabolism Role|nmod|END_ENTITY	Role of acyl-CoA_binding_protein in acyl-CoA metabolism and acyl-CoA-mediated cell signaling .
11404184	0	acyl-CoA	19,27	acyl-CoA_binding_protein	33,57	acyl-CoA	acyl-CoA binding protein	MESH:D000214	25045(Tax:10116)	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	The interaction of acyl-CoA with acyl-CoA_binding_protein and carnitine_palmitoyltransferase_I .
8318018	0	acyl-CoA	70,78	acyl-CoA_binding_protein	15,39	acyl-CoA	acyl-CoA binding protein	MESH:D000214	25045(Tax:10116)	Chemical	Gene	processes|nmod|START_ENTITY END_ENTITY|nmod|processes	Interaction of acyl-CoA_binding_protein -LRB- ACBP -RRB- on processes for which acyl-CoA is a substrate , product or inhibitor .
1805095	0	acyl-CoA	150,158	cholesterol_7_alpha-hydroxylase	98,129	acyl-CoA	cholesterol 7 alpha-hydroxylase	MESH:D000214	25428(Tax:10116)	Chemical	Gene	acyltransferase|amod|START_ENTITY acyltransferase|amod|END_ENTITY	Effects of perturbations in hepatic free and esterified cholesterol pools on bile_acid synthesis , cholesterol_7_alpha-hydroxylase , HMG-CoA_reductase , acyl-CoA : cholesterol acyltransferase and cytosolic cholesteryl_ester hydrolase .
1556096	0	acyl-CoA_esters	27,42	insulin	93,100	acyl-CoA esters	insulin	null	3630	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Malonyl-CoA and long chain acyl-CoA_esters as metabolic coupling factors in nutrient-induced insulin secretion .
8130278	0	acyl-CoA_esters	32,47	protein_kinase_C	51,67	acyl-CoA esters	protein kinase C	null	112476	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effect of fatty_acids and their acyl-CoA_esters on protein_kinase_C activity in fibroblasts : possible implications in fatty_acid oxidation defects .
23826266	3	acyl-CoAs	374,383	ELOVL4	413,419	acyl-CoAs	ELOVL4	null	6785	Chemical	Gene	START_ENTITY|acl|produced produced|nmod|END_ENTITY	ULC acyl-CoAs , produced by the FA elongase ELOVL4 , are converted to ULC CERs by the CER synthase CERS3 .
11853686	0	acyl-coenzyme_A	152,167	ACAT	198,202	acyl-coenzyme A	ACAT	MESH:D000214	1066	Chemical	Gene	avasimibe|appos|START_ENTITY mediating|nmod|avasimibe mechanisms|acl|mediating mechanisms|dep|cholesterol_acyltransferase cholesterol_acyltransferase|appos|END_ENTITY	Intracellular mechanisms mediating the inhibition of apoB-containing lipoprotein synthesis and secretion in HepG2 cells by avasimibe -LRB- CI-1011 -RRB- , a novel acyl-coenzyme_A : _ cholesterol_acyltransferase -LRB- ACAT -RRB- inhibitor .
20571114	0	acyl-coenzyme_A	24,39	FAR1	52,56	acyl-coenzyme A	FAR1	MESH:D000214	827173(Tax:3702)	Chemical	Gene	reductases|amod|START_ENTITY reductases|appos|END_ENTITY	Three Arabidopsis fatty acyl-coenzyme_A reductases , FAR1 , FAR4 , and FAR5 , generate primary fatty_alcohols associated with suberin deposition .
16650827	0	acyl_CoA	26,34	AOX	44,47	acyl CoA	AOX	MESH:D000214	11430(Tax:10090)	Chemical	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	STAT5 activators modulate acyl_CoA oxidase -LRB- AOX -RRB- expression in adipocytes and STAT5A binds to the AOX promoter in vitro .
16650827	0	acyl_CoA	26,34	AOX	98,101	acyl CoA	AOX	MESH:D000214	11430(Tax:10090)	Chemical	Gene	expression|compound|START_ENTITY modulate|dobj|expression modulate|nmod|promoter promoter|compound|END_ENTITY	STAT5 activators modulate acyl_CoA oxidase -LRB- AOX -RRB- expression in adipocytes and STAT5A binds to the AOX promoter in vitro .
8483897	0	acyl_glucuronides	33,50	albumin	60,67	acyl glucuronides	albumin	null	213	Chemical	Gene	Evidence|nmod|START_ENTITY Evidence|nmod|END_ENTITY	Evidence for covalent binding of acyl_glucuronides to serum albumin via an imine mechanism as revealed by tandem mass spectrometry .
23047286	0	acyl_indole	39,50	PPAR	66,70	acyl indole	PPAR	null	19013(Tax:10090)	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Effect of oxime_ether incorporation in acyl_indole derivatives on PPAR subtype selectivity .
22194889	0	acylated_steryl_b-glucosides	19,47	IGF-1	0,5	acylated steryl b-glucosides	IGF-1	null	24482(Tax:10116)	Chemical	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	IGF-1 induction by acylated_steryl_b-glucosides found in a pre-germinated brown_rice diet reduces oxidative stress in streptozotocin-induced diabetes .
1635814	0	acylcarnitines	21,35	medium-chain_acyl-CoA_dehydrogenase	39,74	acylcarnitines	medium-chain acyl-CoA dehydrogenase	null	34	Chemical	Gene	START_ENTITY|nmod|deficiency deficiency|amod|END_ENTITY	Urinary medium-chain acylcarnitines in medium-chain_acyl-CoA_dehydrogenase deficiency , medium-chain triglyceride feeding and valproic_acid therapy : sensitivity and specificity of the radioisotopic exchange/high performance liquid chromatography method .
26056268	0	acylceramide	67,79	CYP4F22	38,45	acylceramide	CYP4F22	null	126410	Chemical	Gene	production|nmod|START_ENTITY END_ENTITY|nmod|production	Essential role of the cytochrome P450 CYP4F22 in the production of acylceramide , the key lipid for skin permeability barrier formation .
8021922	0	acyloxy	47,54	cathepsin_B	22,33	acyloxy	cathepsin B	null	64529(Tax:10116)	Chemical	Gene	inhibition|appos|START_ENTITY inhibition|nmod|END_ENTITY	In vivo inhibition of cathepsin_B by peptidyl -LRB- acyloxy -RRB- methyl_ketones .
12974392	0	acyloxymethylketone	21,40	asparaginyl_endopeptidase	55,80	acyloxymethylketone	asparaginyl endopeptidase	null	5641	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|nmod|END_ENTITY	Novel cell-permeable acyloxymethylketone inhibitors of asparaginyl_endopeptidase .
8931734	0	acylpeptide	85,96	apolipoprotein_E	15,31	acylpeptide	apolipoprotein E	null	348	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Stimulation Stimulation|nmod|END_ENTITY	Stimulation of apolipoprotein_E secretion in human hepatoma Hep G2 cells by a cyclic acylpeptide , N-4909 .
25089810	0	acylureidoindolin-2-one	6,29	Aurora_B	50,58	acylureidoindolin-2-one	Aurora B	null	9212	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Novel acylureidoindolin-2-one derivatives as dual Aurora_B / FLT3 inhibitors for the treatment of acute_myeloid_leukemia .
16899366	0	adamantane	62,72	11beta-HSD1	73,84	adamantane	11beta-HSD1	MESH:D000218	3290;26871	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Synthesis and biological evaluation of heterocycle containing adamantane 11beta-HSD1 inhibitors .
26218650	0	adamantane_carboxylic_acid	30,56	diacylglycerol_acyltransferase_1	79,111	adamantane carboxylic acid	diacylglycerol acyltransferase 1	MESH:C012698	13350(Tax:10090)	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Discovery and optimization of adamantane_carboxylic_acid derivatives as potent diacylglycerol_acyltransferase_1 inhibitors for the potential treatment of obesity and diabetes .
17110106	0	adamantane_ethers	13,30	11beta-HSD-1	48,60	adamantane ethers	11beta-HSD-1	null	3290	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Discovery of adamantane_ethers as inhibitors of 11beta-HSD-1 : Synthesis and biological evaluation .
16772540	0	adamantyl-urea	12,26	soluble_epoxide_hydrolase	45,70	adamantyl-urea	soluble epoxide hydrolase	null	65030(Tax:10116)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Substituted adamantyl-urea inhibitors of the soluble_epoxide_hydrolase dilate mesenteric resistance vessels .
17350260	0	adamantyl_amide	39,54	11beta-HSD1	55,66	adamantyl amide	11beta-HSD1	null	3290;26871	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Discovery and biological evaluation of adamantyl_amide 11beta-HSD1 inhibitors .
17518990	0	adapalene	48,57	TLR-2	23,28	adapalene	TLR-2	MESH:C063610	7097	Chemical	Gene	START_ENTITY|nmod|modulation modulation|nmod|END_ENTITY	In vitro modulation of TLR-2 , CD1d and IL-10 by adapalene on normal human skin and acne inflammatory lesions .
21244849	0	adefovir	99,107	organic_anion_transporter_1	120,147	adefovir	organic anion transporter 1	MESH:C053001	9356	Chemical	Gene	START_ENTITY|acl|mediated mediated|nmod|END_ENTITY	Flavonoid conjugates interact with organic anion transporters -LRB- OATs -RRB- and attenuate cytotoxicity of adefovir mediated by organic_anion_transporter_1 -LRB- OAT1/SLC22A6 -RRB- .
10991954	0	adefovir	90,98	renal_organic_anion_transporter_1	121,154	adefovir	renal organic anion transporter 1	MESH:C053001	9356	Chemical	Gene	START_ENTITY|acl|mediated mediated|nmod|END_ENTITY	Nonsteroidal anti-inflammatory drugs efficiently reduce the transport and cytotoxicity of adefovir mediated by the human renal_organic_anion_transporter_1 .
19735648	0	adefovir_dipivoxil	95,113	MRP4	39,43	adefovir dipivoxil	MRP4	MESH:C106812	10257	Chemical	Gene	absorption|nmod|START_ENTITY END_ENTITY|nmod|absorption	Role of basolateral efflux transporter MRP4 in the intestinal absorption of the antiviral drug adefovir_dipivoxil .
6291673	0	adenine	10,17	HCN	32,35	adenine	HCN	MESH:D000225	378938	Chemical	Gene	synthesis|compound|START_ENTITY synthesis|nmod|END_ENTITY	Prebiotic adenine synthesis via HCN oligomerization in ice .
11087392	0	adenine	53,60	c-Abl	79,84	adenine	c-Abl	MESH:D000225	25	Chemical	Gene	pocket|amod|START_ENTITY pocket|nmod|END_ENTITY	Src-Abl tyrosine kinase chimeras : replacement of the adenine binding pocket of c-Abl with v-Src to swap nucleotide and inhibitor specificities .
12022886	0	adenine	51,58	glutamate_dehydrogenase	110,133	adenine	glutamate dehydrogenase	MESH:D000225	2746	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Cassette mutagenesis and photoaffinity labeling of adenine binding domain of ADP regulatory site within human glutamate_dehydrogenase .
8816952	0	adenine	18,25	glutamate_dehydrogenase	84,107	adenine	glutamate dehydrogenase	MESH:D000225	281785(Tax:9913)	Chemical	Gene	peptides|amod|START_ENTITY Identification|nmod|peptides Identification|nmod|END_ENTITY	Identification of adenine binding domain peptides of the ADP regulatory site within glutamate_dehydrogenase .
17511349	0	adenine	45,52	xanthine_oxidoreductase	10,33	adenine	xanthine oxidoreductase	MESH:D000225	497811(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|dep|effect	Rat liver xanthine_oxidoreductase : effect of adenine on the oxidase and dehydrogenase activities .
426502	0	adenine_arabinoside	45,64	antidiuretic_hormone	14,34	adenine arabinoside	antidiuretic hormone	MESH:D014740	551	Chemical	Gene	administration|amod|START_ENTITY END_ENTITY|nmod|administration	Inappropriate antidiuretic_hormone following adenine_arabinoside administration .
3025205	0	adenine_dinucleotide	25,45	S-adenosylhomocysteine_hydrolase	80,112	adenine dinucleotide	S-adenosylhomocysteine hydrolase	null	508158(Tax:9913)	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	The role of nicotinamide adenine_dinucleotide in the inhibition of bovine liver S-adenosylhomocysteine_hydrolase by neplanocin_A .
3343337	1	adenine_dinucleotide	128,148	oxidoreductase	149,163	adenine dinucleotide	oxidoreductase	null	7296	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Impaired fatty alcohol oxidation in cultured fibroblasts due to deficient fatty alcohol : nicotinamide adenine_dinucleotide oxidoreductase activity .
6980397	0	adenine_nucleosides	32,51	adenosine_deaminase	69,88	adenine nucleosides	adenosine deaminase	null	100	Chemical	Gene	START_ENTITY|nmod|children children|nmod|deficiency deficiency|amod|END_ENTITY	Increased excretion of modified adenine_nucleosides by children with adenosine_deaminase deficiency .
16402039	0	adenine_nucleotide	63,81	ANT	95,98	adenine nucleotide	ANT	CHEBI:61293	293	Chemical	Gene	translocase|amod|START_ENTITY translocase|appos|END_ENTITY	A new endogenous ATP analog -LRB- ApppI -RRB- inhibits the mitochondrial adenine_nucleotide translocase -LRB- ANT -RRB- and is responsible for the apoptosis induced by nitrogen-containing bisphosphonates .
19161974	0	adenine_nucleotide	29,47	ANT	61,64	adenine nucleotide	ANT	CHEBI:61293	293	Chemical	Gene	translocase|amod|START_ENTITY translocase|appos|END_ENTITY	Ca -LRB- 2 + -RRB- binding to c-state of adenine_nucleotide translocase -LRB- ANT -RRB- - surrounding cardiolipins enhances -LRB- ANT -RRB- - Cys -LRB- 56 -RRB- relative mobility : a computational-based mitochondrial permeability transition study .
24819348	0	adenine_nucleotide	14,32	ANT	46,49	adenine nucleotide	ANT	CHEBI:61293	293	Chemical	Gene	translocase|amod|START_ENTITY translocase|dep|END_ENTITY	Expression of adenine_nucleotide translocase -LRB- ANT -RRB- isoform genes is controlled by PGC-1a through different transcription factors .
10411310	0	adenine_nucleotide	34,52	ANT1	66,70	adenine nucleotide	ANT1	CHEBI:61293	85333(Tax:10116)	Chemical	Gene	RNA|compound|START_ENTITY RNA|compound|END_ENTITY	Estrogen stimulates expression of adenine_nucleotide translocator ANT1 messenger RNA in female rat hearts .
15231833	0	adenine_nucleotide	58,76	ANT1	92,96	adenine nucleotide	ANT1	CHEBI:61293	291	Chemical	Gene	translocase|amod|START_ENTITY translocase|appos|END_ENTITY	Recruitment of NF-kappaB into mitochondria is involved in adenine_nucleotide translocase 1 -LRB- ANT1 -RRB- - induced apoptosis .
1582253	0	adenine_nucleotide	31,49	ANT1	69,73	adenine nucleotide	ANT1	CHEBI:61293	291	Chemical	Gene	START_ENTITY|dobj|gene gene|appos|END_ENTITY	Assignment of the human muscle adenine_nucleotide translocator gene -LRB- ANT1 -RRB- to 4q35 by fluorescence in situ hybridization .
10222150	0	adenine_nucleotide	39,57	ANT2	73,77	adenine nucleotide	ANT2	CHEBI:61293	293	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The growth-dependent expression of the adenine_nucleotide translocase-2 -LRB- ANT2 -RRB- gene is regulated at the level of transcription and is a marker of cell proliferation .
11085946	0	adenine_nucleotide	29,47	ANT2	64,68	adenine nucleotide	ANT2	CHEBI:61293	293	Chemical	Gene	mapping|nmod|START_ENTITY provides|nmod|mapping provides|nsubj|promoter promoter|appos|END_ENTITY	In vivo mapping of the human adenine_nucleotide translocator-2 -LRB- ANT2 -RRB- promoter provides support for regulation by a pair of proximal Sp1-activating sites and an upstream silencer element .
11683873	0	adenine_nucleotide	37,55	ANT2	71,75	adenine nucleotide	ANT2	CHEBI:61293	293	Chemical	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Sp1 acts as a repressor of the human adenine_nucleotide translocase-2 -LRB- ANT2 -RRB- promoter .
26883272	0	adenine_nucleotide	10,28	ANT2	44,48	adenine nucleotide	ANT2	CHEBI:61293	293	Chemical	Gene	START_ENTITY|xcomp|translocase-2 translocase-2|dep|END_ENTITY	Targeting adenine_nucleotide translocase-2 -LRB- ANT2 -RRB- to overcome resistance to epidermal_growth_factor_receptor tyrosine kinase inhibitor in non-small_cell_lung_cancer .
2900778	0	adenine_nucleotide	6,24	ATPase	62,68	adenine nucleotide	ATPase	CHEBI:61293	1769	Chemical	Gene	sites|amod|START_ENTITY sites|nmod|END_ENTITY	Three adenine_nucleotide binding sites in F1-F0 mitochondrial ATPase as revealed by presteady-state and steady-state kinetics of ATP hydrolysis .
8476415	0	adenine_nucleotide	50,68	Anc2	45,49	adenine nucleotide	Anc2	CHEBI:61293	852250(Tax:4932)	Chemical	Gene	START_ENTITY|nsubj|characterisation characterisation|nmod|END_ENTITY	Biochemical characterisation of the isolated Anc2 adenine_nucleotide carrier from Saccharomyces_cerevisiae mitochondria .
8812469	0	adenine_nucleotide	23,41	Ant2	62,66	adenine nucleotide	Ant2	CHEBI:61293	11740(Tax:10090)	Chemical	Gene	gene|amod|START_ENTITY mapping|nmod|gene mapping|appos|END_ENTITY	Genetic mapping of the adenine_nucleotide translocase-2 gene -LRB- Ant2 -RRB- to the mouse proximal X chromosome .
588575	0	adenine_nucleotide	11,29	Ca2	78,81	adenine nucleotide	Ca2	CHEBI:61293	100154873(Tax:9823)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Effects of adenine_nucleotide translocase inhibitors on dinitrophenol-induced Ca2 + efflux from pig heart mitochondria .
11306353	0	adenine_nucleotide	41,59	Hsp90	70,75	adenine nucleotide	Hsp90	CHEBI:61293	3320	Chemical	Gene	pocket|amod|START_ENTITY pocket|nmod|END_ENTITY	A small molecule designed to bind to the adenine_nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast_cancer cells .
5675431	1	adenine_nucleotide	148,166	thrombin	71,79	adenine nucleotide	thrombin	CHEBI:61293	2147	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of thrombin , adenosine_diphosphate , and epinephrine on intra - and extracellular adenine_nucleotide kinetics .
7105653	0	adenine_nucleotides	59,78	Citrate_synthase	0,16	adenine nucleotides	Citrate synthase	MESH:D000227	397519(Tax:9823)	Chemical	Gene	inhibition|nmod|START_ENTITY END_ENTITY|dep|inhibition	Citrate_synthase from Crithidia fasciculata : inhibition by adenine_nucleotides and suramin .
19713962	0	adenine_nucleotides	43,62	ClC-5	34,39	adenine nucleotides	ClC-5	MESH:D000227	1184	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Intracellular regulation of human ClC-5 by adenine_nucleotides .
18524768	0	adenine_nucleotides	33,52	Synaptic_vesicle_protein_2	0,26	adenine nucleotides	Synaptic vesicle protein 2	MESH:D000227	9900	Chemical	Gene	START_ENTITY|nsubj|binds binds|amod|END_ENTITY	Synaptic_vesicle_protein_2 binds adenine_nucleotides .
9623802	0	adenine_nucleotides	83,102	cytochrome_c_oxidase	59,79	adenine nucleotides	cytochrome c oxidase	MESH:D000227	282199(Tax:9913)	Chemical	Gene	transfer|nmod|START_ENTITY transfer|nmod|END_ENTITY	Regulation of energy transduction and electron transfer in cytochrome_c_oxidase by adenine_nucleotides .
624943	0	adenine_nucleotides	64,83	glutamate_decarboxylase	109,132	adenine nucleotides	glutamate decarboxylase	MESH:D000227	2752	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Studies on the regulation of GABA synthesis : the interaction of adenine_nucleotides and glutamate with brain glutamate_decarboxylase .
12062900	0	adenine_nucleotides	8,27	insulin	31,38	adenine nucleotides	insulin	MESH:D000227	3630	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Role of adenine_nucleotides in insulin secretion from MIN6 pseudoislets .
3707142	0	adenine_nucleotides	48,67	malate_dehydrogenase	15,35	adenine nucleotides	malate dehydrogenase	MESH:D000227	102598070	Chemical	Gene	control|nmod|START_ENTITY control|nmod|activity activity|amod|END_ENTITY	The control of malate_dehydrogenase activity by adenine_nucleotides in purified potato tuber -LRB- Solanum_tuberosum_L . -RRB-
4672793	0	adenine_nucleotides	74,93	thrombin	11,19	adenine nucleotides	thrombin	MESH:D000227	2147	Chemical	Gene	Effects|dep|START_ENTITY Effects|nmod|END_ENTITY	Effects of thrombin and serotonin upon the energetics of blood platelets : adenine_nucleotides and some related enzymes .
22791815	0	adenines	73,81	p53	102,105	adenines	p53	null	7157	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Chromium _ -LRB- VI -RRB- induces both bulky DNA adducts and oxidative DNA damage at adenines and guanines in the p53 gene of human lung cells .
17996310	0	adenoids	64,72	Bak	4,7	adenoids	Bak	null	578	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	The Bak protein expression in germinal centers of hypertrophied adenoids in children .
14643483	0	adenoids	66,74	Bcl-2	4,9	adenoids	Bcl-2	null	596	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	The Bcl-2 protein expression in germinal centers of hypertrophied adenoids in children .
16685136	0	adenoids	38,46	Fas_ligand	14,24	adenoids	Fas ligand	null	356	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of Fas_ligand and CTLA4 in adenoids has a predictive value for allergic_rhinitis development in children .
23318123	0	adenoids	59,67	TIMP-1	4,10	adenoids	TIMP-1	null	7076	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	The TIMP-1 expression in germinal centers of hypertrophied adenoids in children .
12903086	0	adenophostin	37,49	IP3_receptor	65,77	adenophostin	IP3 receptor	null	3710	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	Synthesis and biological activity of adenophostin derivatives as IP3_receptor ligands .
3703020	0	adenosine	47,56	A-1	33,36	adenosine	A-1	MESH:D000241	113992(Tax:10116)	Chemical	Gene	START_ENTITY|amod|binding binding|nmod|END_ENTITY	Evaluation of the binding of the A-1 selective adenosine radioligand , cyclopentyladenosine -LRB- CPA -RRB- , to rat brain tissue .
26462195	0	adenosine	27,36	A1/A2A	37,43	adenosine	A1/A2A	MESH:D000241	113992;64159	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|compound|END_ENTITY	2-Aminopyrimidines as dual adenosine A1/A2A antagonists .
15987272	0	adenosine	58,67	A1_and_A_2A	68,79	adenosine	A1 and A 2A	MESH:D000241	64159(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Long-term effect of convulsive behavior on the density of adenosine A1_and_A_2A receptors in the rat cerebral cortex .
26335190	0	adenosine	61,70	A1_and_A_2A	71,82	adenosine	A1 and A 2A	MESH:D000241	109667(Tax:10090)	Chemical	Gene	modulation|compound|START_ENTITY modulation|amod|END_ENTITY	Presymptomatic and symptomatic ALS SOD1 -LRB- G93A -RRB- mice differ in adenosine A1_and_A_2A receptor-mediated tonic modulation of neuromuscular transmission .
15341591	0	adenosine	16,25	A1_receptor	26,37	adenosine	A1 receptor	MESH:D000241	11539(Tax:10090)	Chemical	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Deletion of the adenosine A1_receptor gene does not alter neuronal_damage following ischaemia in vivo or in vitro .
26521438	0	adenosine	102,111	A1_receptor	19,30	adenosine	A1 receptor	MESH:D000241	11539(Tax:10090)	Chemical	Gene	derivative|amod|START_ENTITY YZG-330|appos|derivative effect|nmod|YZG-330 involved|nmod|effect involved|nsubj|END_ENTITY	-LSB- Central-adenosine A1_receptor involved in the thermal regulation effect of YZG-330 , a N6-substituted adenosine derivative , in mice -RSB- .
10943728	0	adenosine	13,22	A2A	9,12	adenosine	A2A	MESH:D000241	64159(Tax:10116)	Chemical	Gene	antagonism|compound|START_ENTITY antagonism|compound|END_ENTITY	Striatal A2A adenosine receptor antagonism differentially modifies striatal glutamate outflow in vivo in young and aged rats .
10999489	0	adenosine	21,30	A2A	104,107	adenosine	A2A	MESH:D000241	28882	Chemical	Gene	analogues|nmod|START_ENTITY analogues|dep|studies studies|nmod|subtypes subtypes|amod|adenosine adenosine|dep|A1 A1|nummod|END_ENTITY	2-Nitro analogues of adenosine and 1-deazaadenosine : synthesis and binding studies at the adenosine A1 , A2A and A3 receptor subtypes .
10999489	0	adenosine	90,99	A2A	104,107	adenosine	A2A	MESH:D000241	28882	Chemical	Gene	START_ENTITY|dep|A1 A1|nummod|END_ENTITY	2-Nitro analogues of adenosine and 1-deazaadenosine : synthesis and binding studies at the adenosine A1 , A2A and A3 receptor subtypes .
11754583	0	adenosine	89,98	A2A	85,88	adenosine	A2A	MESH:D000241	28882	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|nummod|END_ENTITY	7-Substituted 5-amino-2 - -LRB- 2-furyl -RRB- pyrazolo -LSB- 4,3-e -RSB- -1,2,4 - triazolo -LSB- 1,5-c -RSB- pyrimidines as A2A adenosine receptor antagonists : a study on the importance of modifications at the side chain on the activity and solubility .
11852293	0	adenosine	58,67	A2A	68,71	adenosine	A2A	MESH:D000241	28882	Chemical	Gene	theophylline|amod|START_ENTITY theophylline|compound|END_ENTITY	A double-blind crossover , placebo-controlled study of the adenosine A2A antagonist theophylline in Parkinson 's _ disease .
12750024	0	adenosine	47,56	A2A	36,39	adenosine	A2A	MESH:D000241	28882	Chemical	Gene	START_ENTITY|nsubj|developments developments|nmod|field field|nmod|END_ENTITY	Recent developments in the field of A2A and A3 adenosine receptor antagonists .
12832562	0	adenosine	15,24	A2A	140,143	adenosine	A2A	MESH:D000241	64159(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY role|nmod|receptors role|dep|implications implications|nmod|potential potential|nmod|antagonists antagonists|nummod|END_ENTITY	A dual role of adenosine A2A receptors in 3-nitropropionic_acid-induced striatal lesions : implications for the neuroprotective potential of A2A antagonists .
12832562	0	adenosine	15,24	A2A	25,28	adenosine	A2A	MESH:D000241	64159(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	A dual role of adenosine A2A receptors in 3-nitropropionic_acid-induced striatal lesions : implications for the neuroprotective potential of A2A antagonists .
14584936	0	adenosine	13,22	A2A	71,74	adenosine	A2A	MESH:D000241	28882	Chemical	Gene	receptors|amod|START_ENTITY Modeling|dobj|receptors comparison|dep|Modeling comparison|nmod|domains domains|nmod|agonists agonists|compound|END_ENTITY	Modeling the adenosine receptors : comparison of the binding domains of A2A agonists and antagonists .
14684247	0	adenosine	4,13	A2A	14,17	adenosine	A2A	MESH:D000241	64159(Tax:10116)	Chemical	Gene	KF17837|amod|START_ENTITY KF17837|compound|END_ENTITY	The adenosine A2A antagonist KF17837 reverses the locomotor suppression and tremulous_jaw_movements induced by haloperidol in rats : possible relevance to parkinsonism .
15808481	0	adenosine	50,59	A2A	46,49	adenosine	A2A	MESH:D000241	28882	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|nummod|END_ENTITY	6 - -LRB- 2-Furanyl -RRB- -9 H-purin-2-amine derivatives as A2A adenosine antagonists .
15968457	0	adenosine	31,40	A2A	41,44	adenosine	A2A	MESH:D000241	64159(Tax:10116)	Chemical	Gene	CSC|amod|START_ENTITY CSC|compound|END_ENTITY	Neuroprotection induced by the adenosine A2A antagonist CSC in the 6-OHDA rat model of parkinsonism : effect on the activity of striatal output pathways .
15978806	0	adenosine	101,110	A2A	111,114	adenosine	A2A	MESH:D000241	64159(Tax:10116)	Chemical	Gene	START_ENTITY|dep|antagonists antagonists|nummod|END_ENTITY	2 - -LRB- 2-Furanyl -RRB- -7 - phenyl -LSB- 1,2,4 -RSB- triazolo -LSB- 1,5-c -RSB- pyrimidin-5-amine analogs : highly potent , orally active , adenosine A2A antagonists .
16867213	0	adenosine	28,37	A2A	24,27	adenosine	A2A	MESH:D000241	28882	Chemical	Gene	antagonist|compound|START_ENTITY antagonist|compound|END_ENTITY	ST_1535 : a preferential A2A adenosine receptor antagonist .
17082635	0	adenosine	42,51	A2A	62,65	adenosine	A2A	MESH:D000241	28882	Chemical	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	IL-1_beta and TNF-alpha regulation of the adenosine receptor -LRB- A2A -RRB- expression : differential requirement for NF-kappa_B binding to the proximal promoter .
17330954	0	adenosine	50,59	A2A	38,41	adenosine	A2A	MESH:D000241	28882	Chemical	Gene	START_ENTITY|nsubj|models models|nmod|END_ENTITY	3D-pharmacophore models for selective A2A and A2B adenosine receptor antagonists .
18508458	0	adenosine	24,33	A2A	34,37	adenosine	A2A	MESH:D000241	64159(Tax:10116)	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|compound|END_ENTITY	Tremorolytic effects of adenosine A2A antagonists : implications for parkinsonism .
18706486	0	adenosine	139,148	A2A	149,152	adenosine	A2A	MESH:D000241	64159(Tax:10116)	Chemical	Gene	START_ENTITY|xcomp|transcription transcription|nsubj|END_ENTITY	Maternal caffeine ingestion during gestation and lactation influences respiratory adaptation to acute alveolar_hypoxia in newborn rats and adenosine A2A and GABA A receptor mRNA transcription .
19287996	0	adenosine	18,27	A2A	38,41	adenosine	A2A	MESH:D000241	28882	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|isoform isoform|compound|END_ENTITY	Crosstalk between adenosine receptor -LRB- A2A isoform -RRB- and ERalpha mediates ethanol action in MCF-7 breast_cancer cells .
19782116	0	adenosine	18,27	A2A	28,31	adenosine	A2A	MESH:D000241	64159(Tax:10116)	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|compound|END_ENTITY	Caffeine and CSC , adenosine A2A antagonists , offer neuroprotection against 6-OHDA-induced neurotoxicity in rat mesencephalic cells .
24483158	0	adenosine	23,32	A2A	42,45	adenosine	A2A	MESH:D000241	28882	Chemical	Gene	agonist|amod|START_ENTITY agonist|compound|END_ENTITY	The effect of PDRN , an adenosine receptor A2A agonist , on the healing of chronic diabetic_foot_ulcers : results of a clinical trial .
24815000	0	adenosine	54,63	A2A	50,53	adenosine	A2A	MESH:D000241	64159(Tax:10116)	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|nummod|END_ENTITY	8-Substituted_2-alkynyl-N -LRB- 9 -RRB- - propargyladenines as A2A adenosine receptor antagonists .
25622143	0	adenosine	11,20	A2A	30,33	adenosine	A2A	MESH:D000241	28882	Chemical	Gene	START_ENTITY|ccomp|regulate regulate|nsubj|END_ENTITY	Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory .
26526685	0	adenosine	76,85	A2A	86,89	adenosine	A2A	MESH:D000241	64159(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	Striatal adenosine-cannabinoid receptor interactions in rats overexpressing adenosine A2A receptors .
9515573	0	adenosine	115,124	A2A	103,106	adenosine	A2A	MESH:D000241	28882	Chemical	Gene	subtypes|compound|START_ENTITY subtypes|compound|END_ENTITY	Pharmacological characterization of adenosine A2B receptors : studies in human mast cells co-expressing A2A and A2B adenosine receptor subtypes .
9515573	0	adenosine	36,45	A2A	103,106	adenosine	A2A	MESH:D000241	28882	Chemical	Gene	receptors|amod|START_ENTITY characterization|nmod|receptors characterization|dep|studies studies|nmod|cells cells|acl|co-expressing co-expressing|dobj|subtypes subtypes|compound|END_ENTITY	Pharmacological characterization of adenosine A2B receptors : studies in human mast cells co-expressing A2A and A2B adenosine receptor subtypes .
26528137	0	adenosine	6,15	A2AR	129,133	adenosine	A2AR	MESH:D000241	11540(Tax:10090)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|nmod|activation activation|nmod|END_ENTITY	Basal adenosine modulates the functional properties of AMPA receptors in mouse hippocampal neurons through the activation of A1R A2AR and A3R .
10092821	0	adenosine	31,40	A2B	27,30	adenosine	A2B	MESH:D000241	11541(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	IFN-gamma up-regulates the A2B adenosine receptor expression in macrophages : a mechanism of macrophage deactivation .
26300787	0	adenosine	3,12	A2B	13,16	adenosine	A2B	MESH:D000241	11541(Tax:10090)	Chemical	Gene	knockouts|amod|START_ENTITY knockouts|compound|END_ENTITY	In adenosine A2B knockouts acute treatment with inorganic nitrate improves glucose disposal , oxidative stress , and AMPK signaling in the liver .
26317647	0	adenosine	51,60	A2B	47,50	adenosine	A2B	MESH:D000241	11541(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY production|nummod|END_ENTITY	Myeloid-derived suppressor cells contribute to A2B adenosine receptor-induced VEGF production and angiogenesis in a mouse melanoma model .
7595490	0	adenosine	25,34	A2a	35,38	adenosine	A2a	MESH:D000241	64159(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Neuroleptics up-regulate adenosine A2a receptors in rat striatum : implications for the mechanism and the treatment of tardive_dyskinesia .
7658444	0	adenosine	57,66	A2a	53,56	adenosine	A2a	MESH:D000241	64159(Tax:10116)	Chemical	Gene	properties|amod|START_ENTITY properties|amod|END_ENTITY	2 - -LSB- N ' - -LRB- 3-arylallylidene -RRB- hydrazino -RSB- adenosines showing A2a adenosine agonist properties and vasodilation activity .
7731018	1	adenosine	59,68	A2a	55,58	adenosine	A2a	MESH:D000241	28882	Chemical	Gene	activities|amod|START_ENTITY activities|amod|END_ENTITY	Synthesis and A1 and A2a adenosine binding activities of some 1-aryl-1 ,4 - dihydro-3-methyl -LSB- 1 -RSB- benzopyrano -LSB- 2,3-c -RSB- _ pyrazol-4-ones , 1-aryl-4 ,9 - dihydro-3-methyl-1H-pyrazolo -LSB- 3,4-b -RSB- quinolin-4 - _ ones , and_1-aryl-1H-imidazo -LSB- 4,5-b -RSB- quinoxalines .
7739005	0	adenosine	94,103	A2a	90,93	adenosine	A2a	MESH:D000241	28882	Chemical	Gene	agonists|compound|START_ENTITY agonists|amod|END_ENTITY	2-Aralkynyl and 2-heteroalkynyl derivatives of adenosine-5 ' - N-ethyluronamide as selective A2a adenosine receptor agonists .
8670304	0	adenosine	63,72	A2a	59,62	adenosine	A2a	MESH:D000241	28882	Chemical	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Characterization and chromosomal localization of the human A2a adenosine receptor gene : ADORA2A .
9491818	0	adenosine	70,79	A2a	66,69	adenosine	A2a	MESH:D000241	28882	Chemical	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Systematic mutation screening and association study of the A1 and A2a adenosine receptor genes in panic_disorder suggest a contribution of the A2a gene to the development of disease .
20039304	0	adenosine	9,18	A2aR	4,8	adenosine	A2aR	MESH:D000241	11540(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	The A2aR adenosine receptor controls cytokine production in iNKT cells .
25779930	0	adenosine	53,62	A2aR	38,42	adenosine	A2aR	MESH:D000241	11540(Tax:10090)	Chemical	Gene	Suppression|dep|START_ENTITY Suppression|nmod|adenosine_2a_receptor adenosine_2a_receptor|appos|END_ENTITY	Suppression of adenosine_2a_receptor -LRB- A2aR -RRB- - mediated adenosine signaling improves disease phenotypes in a mouse model of amyotrophic_lateral_sclerosis .
25779930	0	adenosine	53,62	A2aR	38,42	adenosine	A2aR	MESH:D000241	11540(Tax:10090)	Chemical	Gene	Suppression|dep|START_ENTITY Suppression|nmod|adenosine_2a_receptor adenosine_2a_receptor|appos|END_ENTITY	Suppression of adenosine_2a_receptor -LRB- A2aR -RRB- - mediated adenosine signaling improves disease phenotypes in a mouse model of amyotrophic_lateral_sclerosis .
11048721	0	adenosine	79,88	A2b	89,92	adenosine	A2b	MESH:D000241	11541(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Netrin-1-mediated axon outgrowth and cAMP production requires interaction with adenosine A2b receptor .
16335918	0	adenosine	90,99	A3	87,89	adenosine	A3	MESH:D000241	10312	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|amod|quinoxaline quinoxaline|nmod|tool tool|nmod|design design|nmod|END_ENTITY	1,2,4-Triazolo -LSB- 1,5-a -RSB- quinoxaline as a versatile tool for the design of selective human A3 adenosine receptor antagonists : synthesis , biological evaluation , and molecular modeling studies of 2 - -LRB- hetero -RRB- aryl - _ and_2-carboxy-substituted derivatives .
16789747	0	adenosine	91,100	A3	88,90	adenosine	A3	MESH:D000241	10312	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|compound|END_ENTITY	4-amido-2-aryl-1 ,2,4 - triazolo -LSB- 4,3-a -RSB- quinoxalin-1-ones as new potent and selective human A3 adenosine receptor antagonists .
17665891	0	adenosine	80,89	A3	77,79	adenosine	A3	MESH:D000241	10312	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|amod|END_ENTITY	New 2-arylpyrazolo -LSB- 3,4-c -RSB- quinoline derivatives as potent and selective human A3 adenosine receptor antagonists .
18000937	0	adenosine	16,25	A3	26,28	adenosine	A3	MESH:D000241	10312	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|compound|END_ENTITY	Selective human adenosine A3 antagonists based on pyrido -LSB- 2,1-f -RSB- purine-2 ,4 - diones : novel features of hA3 antagonist binding .
25497490	0	adenosine	79,88	A3	89,91	adenosine	A3	MESH:D000241	28883	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|compound|END_ENTITY	1,2,4-Triazolo -LSB- 1,5-a -RSB- quinoxaline derivatives and their simplified analogues as adenosine A3 receptor antagonists .
26638043	0	adenosine	130,139	A3	127,129	adenosine	A3	MESH:D000241	10312	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Structural refinement of pyrazolo -LSB- 4,3-d -RSB- pyrimidine derivatives to obtain highly potent and selective antagonists for the human A3 adenosine receptor .
9845970	0	adenosine	39,48	A3	36,38	adenosine	A3	MESH:D000241	10312	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|compound|END_ENTITY	Molecular modeling studies of human A3 adenosine antagonists : structural homology and receptor docking .
2912887	1	adenosine	69,78	ADA	127,130	adenosine	ADA	MESH:D000241	100	Chemical	Gene	modulation|nmod|START_ENTITY modulation|appos|END_ENTITY	In vitro modulation by adenosine and inosine and effects of adenosine_deaminase -LRB- ADA -RRB- polymorphism .
10430867	0	adenosine	61,70	ADAR	96,100	adenosine	ADAR	MESH:D000241	103	Chemical	Gene	Identification|nmod|START_ENTITY deaminase|nsubj|Identification deaminase|xcomp|related related|nmod|family family|amod|END_ENTITY	Identification and characterization of a human tRNA-specific adenosine deaminase related to the ADAR family of pre-mRNA editing enzymes .
17897325	0	adenosine	21,30	ADAR	59,63	adenosine	ADAR	MESH:D000241	103	Chemical	Gene	Induction|nmod|START_ENTITY deaminase|nsubj|Induction deaminase|ccomp|-1 -1|nsubj|acts acts|appos|END_ENTITY	Induction of 150-kDa adenosine deaminase that acts on RNA -LRB- ADAR -RRB- -1 gene expression in normal T lymphocytes by anti-CD3-epsilon and anti-CD28 .
9636358	0	adenosine	68,77	ADAR	63,67	adenosine	ADAR	MESH:D000241	103	Chemical	Gene	deaminase|compound|START_ENTITY deaminase|amod|END_ENTITY	Adenovirus VAI RNA antagonizes the RNA-editing activity of the ADAR adenosine deaminase .
10095120	0	adenosine	69,78	ADAR1	146,151	adenosine	ADAR1	MESH:D000241	103	Chemical	Gene	gene|amod|START_ENTITY gene|nmod|promoter promoter|compound|END_ENTITY	Characterization of the 5 ' - flanking region of the human RNA-specific adenosine deaminase ADAR1 gene and identification of an interferon-inducible ADAR1 promoter .
10095120	0	adenosine	69,78	ADAR1	89,94	adenosine	ADAR1	MESH:D000241	103	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Characterization of the 5 ' - flanking region of the human RNA-specific adenosine deaminase ADAR1 gene and identification of an interferon-inducible ADAR1 promoter .
10200312	0	adenosine	19,28	ADAR1	39,44	adenosine	ADAR1	MESH:D000241	103	Chemical	Gene	START_ENTITY|ccomp|possess possess|nsubj|transcripts transcripts|compound|END_ENTITY	Human RNA-specific adenosine deaminase ADAR1 transcripts possess alternative exon 1 structures that initiate from different promoters , one constitutively active and the other interferon inducible .
11041852	0	adenosine	20,29	ADAR1	41,46	adenosine	ADAR1	MESH:D000241	103	Chemical	Gene	START_ENTITY|ccomp|have have|nsubj|END_ENTITY	Double-stranded RNA adenosine deaminases ADAR1 and ADAR2 have overlapping specificities .
11070079	0	adenosine	38,47	ADAR1	147,152	adenosine	ADAR1	MESH:D000241	103	Chemical	Gene	START_ENTITY|ccomp|reveal reveal|nmod|PKR PKR|compound|END_ENTITY	Chimeric double-stranded RNA-specific adenosine deaminase ADAR1 proteins reveal functional selectivity of double-stranded RNA-binding domains from ADAR1 and protein kinase PKR .
11070079	0	adenosine	38,47	ADAR1	58,63	adenosine	ADAR1	MESH:D000241	103	Chemical	Gene	START_ENTITY|ccomp|reveal reveal|nsubj|proteins proteins|compound|END_ENTITY	Chimeric double-stranded RNA-specific adenosine deaminase ADAR1 proteins reveal functional selectivity of double-stranded RNA-binding domains from ADAR1 and protein kinase PKR .
11111054	0	adenosine	19,28	ADAR1	40,45	adenosine	ADAR1	MESH:D000241	103	Chemical	Gene	START_ENTITY|dobj|gene gene|appos|END_ENTITY	Human RNA-specific adenosine deaminase -LRB- ADAR1 -RRB- gene specifies transcripts that initiate from a constitutively active alternative promoter .
12568723	0	adenosine	85,94	ADAR1	105,110	adenosine	ADAR1	MESH:D000241	103	Chemical	Gene	element|nmod|START_ENTITY analysis|nmod|element deaminase|nsubj|analysis deaminase|dobj|promoter promoter|compound|END_ENTITY	Functional analysis of the KCS-like element of the interferon-inducible RNA-specific adenosine deaminase ADAR1 promoter .
19913273	0	adenosine	4,13	ADAR1	24,29	adenosine	ADAR1	MESH:D000241	103	Chemical	Gene	deficiency|compound|START_ENTITY deficiency|compound|END_ENTITY	RNA adenosine deaminase ADAR1 deficiency leads to increased activation of protein kinase PKR and reduced vesicular_stomatitis virus growth following interferon treatment .
24905200	0	adenosine	15,24	ADAR1	66,71	adenosine	ADAR1	MESH:D000241	103	Chemical	Gene	deaminase|amod|START_ENTITY deaminase|acl|acting acting|nmod|RNA RNA|appos|END_ENTITY	An RNA editor , adenosine deaminase acting on double-stranded RNA -LRB- ADAR1 -RRB- .
26817845	0	adenosine	33,42	ADAR1	53,58	adenosine	ADAR1	MESH:D000241	56417(Tax:10090)	Chemical	Gene	suppresses|amod|START_ENTITY suppresses|compound|END_ENTITY	Editing of cellular self RNAs by adenosine deaminase ADAR1 suppresses innate immune stress responses .
12459255	0	adenosine	40,49	ADAR2	60,65	adenosine	ADAR2	MESH:D000241	104	Chemical	Gene	genes|amod|START_ENTITY genes|compound|END_ENTITY	Phylogenetic comparison of the pre-mRNA adenosine deaminase ADAR2 genes and transcripts : conservation and diversity in editing site sequence and alternative splicing patterns .
10836796	0	adenosine	35,44	ADAR3	68,73	adenosine	ADAR3	MESH:D000241	105	Chemical	Gene	family|amod|START_ENTITY family|appos|END_ENTITY	A third member of the RNA-specific adenosine deaminase gene family , ADAR3 , contains both single - and double-stranded RNA binding domains .
7558011	0	adenosine	54,63	ADORA2B	79,86	adenosine	ADORA2B	MESH:D000241	136	Chemical	Gene	START_ENTITY|dobj|gene gene|appos|END_ENTITY	Cloning and chromosomal localization of the human A2b adenosine receptor gene -LRB- ADORA2B -RRB- and its pseudogene .
24038379	0	adenosine	125,134	ATP7A	153,158	adenosine	ATP7A	MESH:D000241	538	Chemical	Gene	A|compound|START_ENTITY A|appos|END_ENTITY	miR-495 enhances the sensitivity of non-small_cell_lung_cancer cells to platinum by modulation of copper-transporting P-type adenosine triphosphatase A -LRB- ATP7A -RRB- .
10965125	0	adenosine	31,40	Adar	57,61	adenosine	Adar	MESH:D000241	56417(Tax:10090)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Assignment of the RNA-specific adenosine deaminase gene -LRB- Adar -RRB- to mouse chromosome 3F2 by in situ hybridization .
18774582	0	adenosine	39,48	Adar1	59,64	adenosine	Adar1	MESH:D000241	56417(Tax:10090)	Chemical	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Organization of the mouse RNA-specific adenosine deaminase Adar1 gene 5 ' - region and demonstration of STAT1-independent , STAT2-dependent transcriptional activation by interferon .
1125070	0	adenosine	73,82	Adenosine_deaminase	0,19	adenosine	Adenosine deaminase	MESH:D000241	100	Chemical	Gene	analogs|amod|START_ENTITY purification|nmod|analogs END_ENTITY|dep|purification	Adenosine_deaminase from human erythrocytes : purification and effects of adenosine analogs .
1709478	0	adenosine	99,108	Adenosine_deaminase	0,19	adenosine	Adenosine deaminase	MESH:D000241	100	Chemical	Gene	depletion|amod|START_ENTITY independent|nmod|depletion increases|nmod|independent increases|nsubj|END_ENTITY	Adenosine_deaminase increases release of excitatory amino_acids through a mechanism independent of adenosine depletion .
1933288	0	adenosine	113,122	Adenosine_deaminase	0,19	adenosine	Adenosine deaminase	MESH:D000241	24165(Tax:10116)	Chemical	Gene	mediation|nmod|START_ENTITY evidence|nmod|mediation reduces|parataxis|evidence reduces|nsubj|END_ENTITY	Adenosine_deaminase reduces hypoxic and hypercapnic_dilatation of rat pial arterioles : evidence for mediation by adenosine .
3992044	0	adenosine	46,55	Adenosine_deaminase	0,19	adenosine	Adenosine deaminase	MESH:D000241	24165(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|dobj|metabolism	Adenosine_deaminase inhibition and myocardial adenosine metabolism during ischemia .
4508567	0	adenosine	56,65	Adenosine_deaminase	0,19	adenosine	Adenosine deaminase	MESH:D000241	100	Chemical	Gene	START_ENTITY|nsubj|inhibition inhibition|amod|END_ENTITY	Adenosine_deaminase inhibition by N 6 - -LRB- 2 - isopentenyl -RRB- adenosine .
6487899	0	adenosine	56,65	Adenosine_deaminase	0,19	adenosine	Adenosine deaminase	MESH:D000241	100720869	Chemical	Gene	stimulation|amod|START_ENTITY antagonizes|nmod|stimulation antagonizes|nsubj|END_ENTITY	Adenosine_deaminase antagonizes inhibitory responses to adenosine and non-adrenergic , non-cholinergic inhibitory nerve stimulation in isolated preparations of guinea-pig trachea .
7606748	0	adenosine	53,62	Adenosine_deaminase	0,19	adenosine	Adenosine deaminase	MESH:D000241	477236(Tax:9615)	Chemical	Gene	augments|dobj|START_ENTITY augments|nsubj|inhibition inhibition|amod|END_ENTITY	Adenosine_deaminase inhibition augments interstitial adenosine but does not attenuate myocardial_infarction .
8601428	0	adenosine	87,96	Adenosine_deaminase	0,19	adenosine	Adenosine deaminase	MESH:D000241	100	Chemical	Gene	receptors|compound|START_ENTITY interacting|nmod|receptors affects|advcl|interacting affects|nsubj|END_ENTITY	Adenosine_deaminase affects ligand-induced signalling by interacting with cell surface adenosine receptors .
8627325	0	adenosine	38,47	Adenosine_deaminase	0,19	adenosine	Adenosine deaminase	MESH:D000241	100625920	Chemical	Gene	receptors|amod|START_ENTITY interacts|nmod|receptors interacts|nsubj|END_ENTITY	Adenosine_deaminase interacts with A1 adenosine receptors in pig brain cortical membranes .
9651356	0	adenosine	27,36	Adenosine_deaminase	0,19	adenosine	Adenosine deaminase	MESH:D000241	100	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Adenosine_deaminase and A1 adenosine receptors internalize together following agonist-induced receptor desensitization .
22389701	0	adenosine	8,17	Adora2b	0,7	adenosine	Adora2b	MESH:D000241	11541(Tax:10090)	Chemical	Gene	engagement|amod|START_ENTITY engagement|nummod|END_ENTITY	Adora2b adenosine receptor engagement enhances regulatory T cell abundance during endotoxin-induced pulmonary_inflammation .
23028059	0	adenosine	8,17	Adora2b	0,7	adenosine	Adora2b	MESH:D000241	11541(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Adora2b adenosine receptor signaling protects during acute_kidney_injury via inhibition of neutrophil-dependent TNF-a release .
23603835	0	adenosine	85,94	Adora2b	77,84	adenosine	Adora2b	MESH:D000241	11541(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Crosstalk between the equilibrative nucleoside transporter ENT2 and alveolar Adora2b adenosine receptors dampens acute_lung_injury .
8595892	0	adenosine	36,45	Adora3	61,67	adenosine	Adora3	MESH:D000241	11542(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|gene gene|appos|END_ENTITY	Chromosomal mapping of the mouse A3 adenosine receptor gene , Adora3 .
10051190	0	adenosine	55,64	CA1	86,89	adenosine	CA1	MESH:D000241	310218(Tax:10116)	Chemical	Gene	accumulation|amod|START_ENTITY accumulation|nmod|END_ENTITY	Masking of forskolin-induced long-term potentiation by adenosine accumulation in area CA1 of the rat hippocampus .
17626785	0	adenosine	8,17	CA1	34,37	adenosine	CA1	MESH:D000241	310218(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|nmod|END_ENTITY	Role of adenosine A3 receptors on CA1 hippocampal neurotransmission during oxygen-glucose_deprivation episodes of different duration .
1745603	0	adenosine	27,36	CA3	52,55	adenosine	CA3	MESH:D000241	761	Chemical	Gene	START_ENTITY|nmod|neurons neurons|compound|END_ENTITY	Postsynaptic inhibition by adenosine in hippocampal CA3 neurons : Co -LRB- 2 + -RRB- - sensitive activation of an inwardly rectifying K + conductance .
18713747	0	adenosine	131,140	CD39	62,66	adenosine	CD39	MESH:D000241	953	Chemical	Gene	hydrolyzing|xcomp|START_ENTITY regulates|advcl|hydrolyzing regulates|nsubj|diphosphohydrolase diphosphohydrolase|appos|END_ENTITY	Ecto-nucleoside_triphosphate diphosphohydrolase 1 -LRB- E-NTPDase1 / CD39 -RRB- regulates neutrophil chemotaxis by hydrolyzing released ATP to adenosine .
21546330	0	adenosine	56,65	CD39	38,42	adenosine	CD39	MESH:D000241	953	Chemical	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	Mesenchymal stromal cells up-regulate CD39 and increase adenosine production to suppress activated T-lymphocytes .
21638125	0	adenosine	102,111	CD39	18,22	adenosine	CD39	MESH:D000241	953	Chemical	Gene	suppression|amod|START_ENTITY responsible|nmod|suppression enzymes|amod|responsible enzymes|nsubj|END_ENTITY	Ectonucleotidases CD39 and CD73 on OvCA cells are potent adenosine-generating enzymes responsible for adenosine receptor 2A-dependent suppression of T cell function and NK cell cytotoxicity .
21638125	0	adenosine	102,111	CD39	18,22	adenosine	CD39	MESH:D000241	953	Chemical	Gene	suppression|amod|START_ENTITY responsible|nmod|suppression enzymes|amod|responsible enzymes|nsubj|END_ENTITY	Ectonucleotidases CD39 and CD73 on OvCA cells are potent adenosine-generating enzymes responsible for adenosine receptor 2A-dependent suppression of T cell function and NK cell cytotoxicity .
21677139	0	adenosine	70,79	CD39	24,28	adenosine	CD39	MESH:D000241	953	Chemical	Gene	production|amod|START_ENTITY suppress|nmod|production END_ENTITY|acl:relcl|suppress	Cancer exosomes express CD39 and CD73 , which suppress T cells through adenosine production .
26549640	0	adenosine	112,121	CD39	23,27	adenosine	CD39	MESH:D000241	953	Chemical	Gene	generation|nmod|START_ENTITY responses|nmod|generation modulates|dobj|responses modulates|dep|NADH NADH|dobj|expression expression|compound|END_ENTITY	NADH oxidase-dependent CD39 expression by CD8 -LRB- + -RRB- T cells modulates interferon_gamma responses via generation of adenosine .
19858205	0	adenosine	49,58	CD4	68,71	adenosine	CD4	MESH:D000241	920	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Generation and accumulation of immunosuppressive adenosine by human CD4 + CD25highFOXP3 + regulatory T cells .
16145841	0	adenosine	31,40	CECR1	25,30	adenosine	CECR1	MESH:D000241	51816	Chemical	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Transgenic expression of CECR1 adenosine deaminase in mice results in abnormal development of heart_and_kidney .
11741811	0	adenosine	5,14	CFTR	34,38	adenosine	CFTR	MESH:D000241	1080	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	A -LRB- 2 -RRB- adenosine receptors regulate CFTR through PKA and PLA -LRB- 2 -RRB- .
17921329	0	adenosine	27,36	COX-1	15,20	adenosine	COX-1	MESH:D000241	17708(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of COX-1 in A3 adenosine receptor-mediated contraction through endothelium in mice aorta .
12916015	0	adenosine	30,39	DSRAD	56,61	adenosine	DSRAD	MESH:D000241	103	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations of the RNA-specific adenosine deaminase gene -LRB- DSRAD -RRB- are involved in dyschromatosis symmetrica hereditaria .
15102079	0	adenosine	36,45	DSRAD	62,67	adenosine	DSRAD	MESH:D000241	103	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Novel mutations of the RNA-specific adenosine deaminase gene -LRB- DSRAD -RRB- in Chinese families with dyschromatosis symmetrica hereditaria .
15659327	2	adenosine	499,508	DSRAD	442,447	adenosine	DSRAD	MESH:D000241	103	Chemical	Gene	deaminase|amod|START_ENTITY encoding|nmod|deaminase gene|acl|encoding gene|amod|END_ENTITY	To date , only three articles testified that DSH is caused by the mutations of DSRAD gene -LRB- also called ADAR1 -RRB- encoding for RNA-specific adenosine deaminase .
8586444	0	adenosine	55,64	DSRAD	81,86	adenosine	DSRAD	MESH:D000241	103	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The interferon-inducible , double-stranded RNA-specific adenosine deaminase gene -LRB- DSRAD -RRB- maps to human chromosome 1q21.1-21 .2 .
11749958	0	adenosine	44,53	ENT1	93,97	adenosine	ENT1	MESH:D000241	843369(Tax:3702)	Chemical	Gene	transporter|amod|START_ENTITY type|nmod|transporter Characterisation|nmod|type Characterisation|nmod|Arabidopsis_thaliana Arabidopsis_thaliana|dep|END_ENTITY	Characterisation of a concentrative type of adenosine transporter from Arabidopsis_thaliana -LRB- ENT1 , At -RRB- .
15258586	2	adenosine	184,193	ENT1	267,271	adenosine	ENT1	MESH:D000241	63959(Tax:10090)	Chemical	Gene	START_ENTITY|xcomp|signaling signaling|advcl|inhibiting inhibiting|dobj|transporter transporter|appos|END_ENTITY	In vitro , ethanol stimulates adenosine signaling by inhibiting the type 1 equilibrative nucleoside transporter -LRB- ENT1 -RRB- , whereas chronic ethanol exposure downregulates ENT1 .
16688763	0	adenosine	21,30	ENT1	43,47	adenosine	ENT1	MESH:D000241	2030	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Nitric_oxide reduces adenosine transporter ENT1 gene -LRB- SLC29A1 -RRB- promoter activity in human fetal endothelium from gestational diabetes .
24163005	0	adenosine	4,13	ENT1	27,31	adenosine	ENT1	MESH:D000241	2030	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	The adenosine transporter , ENT1 , in cardiomyocytes is sensitive to inhibition by ethanol in a kinase-dependent manner : implications for ethanol-dependent cardioprotection and nucleoside analog drug cytotoxicity .
17616749	0	adenosine	20,29	ERK1/2	48,54	adenosine	ERK1/2	MESH:D000241	5595;5594	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The central role of adenosine in statin-induced ERK1/2 , Akt , and eNOS phosphorylation .
9878686	0	adenosine	130,139	Epidermal_growth_factor	0,23	adenosine	Epidermal growth factor	MESH:D000241	1950	Chemical	Gene	receptors|amod|START_ENTITY END_ENTITY|nmod|receptors	Epidermal_growth_factor -LRB- EGF -RRB- - induced up-regulation and agonist - and antagonist-induced desensitization and internalization of A1 adenosine receptors in a pituitary-derived cell line .
8971428	0	adenosine	119,128	Erythropoietin	0,14	adenosine	Erythropoietin	MESH:D000241	2056	Chemical	Gene	role|nmod|START_ENTITY evidence|nmod|role production|dep|evidence production|compound|END_ENTITY	Erythropoietin production in healthy volunteers subjected to controlled haemorrhage : evidence against a major role for adenosine .
9278212	0	adenosine	127,136	Erythropoietin	0,14	adenosine	Erythropoietin	MESH:D000241	2056	Chemical	Gene	role|nmod|START_ENTITY evidence|nmod|role production|dep|evidence production|compound|END_ENTITY	Erythropoietin production in healthy volunteers subjected to controlled hypobaric hypoxia : further evidence against a role for adenosine .
26622427	0	adenosine	10,19	GLAST	23,28	adenosine	GLAST	MESH:D000241	29483(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of adenosine on GLAST expression in the retina of a chronic_ocular_hypertension rat model .
23995793	0	adenosine	63,72	GLI	108,111	adenosine	GLI	MESH:D000241	2735	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|compound|END_ENTITY	Imiquimod directly inhibits Hedgehog signalling by stimulating adenosine receptor/protein kinase A-mediated GLI phosphorylation .
14734746	0	adenosine	18,27	IFN-alpha	0,9	adenosine	IFN-alpha	MESH:D000241	3439	Chemical	Gene	production|compound|START_ENTITY production|amod|END_ENTITY	IFN-alpha induced adenosine production on the endothelium : a mechanism mediated by CD73 -LRB- ecto-5 ' - nucleotidase -RRB- up-regulation .
23097357	0	adenosine	63,72	IL-1b	121,126	adenosine	IL-1b	MESH:D000241	16176(Tax:10090)	Chemical	Gene	treatment|amod|START_ENTITY exerted|nmod|treatment exerted|nmod|chondrocytes chondrocytes|acl|stimulated stimulated|nmod|END_ENTITY	Protein kinase a mediated anti-inflammatory effects exerted by adenosine treatment in mouse chondrocytes stimulated with IL-1b .
24907587	0	adenosine	26,35	IL-1b	55,60	adenosine	IL-1b	MESH:D000241	16176(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY Adenosine|nmod|receptor increases|nsubj|Adenosine increases|dobj|END_ENTITY	Adenosine through the A2A adenosine receptor increases IL-1b in the brain contributing to anxiety .
18442791	0	adenosine	29,38	IL-4	11,15	adenosine	IL-4	MESH:D000241	3565	Chemical	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Effects of IL-4 and IL-13 on adenosine receptor expression and responsiveness of the human mast cell line 1 .
24136993	0	adenosine	16,25	JunB	8,12	adenosine	JunB	MESH:D000241	16477(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY Role|nmod|production Role|nmod|END_ENTITY	Role of JunB in adenosine A2B receptor-mediated vascular_endothelial_growth_factor production .
11014613	0	adenosine	36,45	Prolactin	0,9	adenosine	Prolactin	MESH:D000241	24683(Tax:10116)	Chemical	Gene	transporters|amod|START_ENTITY modulate|dobj|transporters modulate|nsubj|END_ENTITY	Prolactin and cyclosporine modulate adenosine transporters and adenosine A1 receptors in the rat brain .
6822509	0	adenosine	11,20	S-adenosylhomocysteine_hydrolase	38,70	adenosine	S-adenosylhomocysteine hydrolase	MESH:D000241	29443(Tax:10116)	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of adenosine to intracellular S-adenosylhomocysteine_hydrolase in isolated rat hepatocytes .
7306081	0	adenosine	44,53	S-adenosylhomocysteine_hydrolase	8,40	adenosine	S-adenosylhomocysteine hydrolase	MESH:D000241	191	Chemical	Gene	metabolism|amod|START_ENTITY Role|nmod|metabolism Role|nmod|END_ENTITY	Role of S-adenosylhomocysteine_hydrolase in adenosine metabolism in mammalian heart .
9708366	0	adenosine	12,21	S-adenosylhomocysteine_hydrolase	35,67	adenosine	S-adenosylhomocysteine hydrolase	MESH:D000241	191	Chemical	Gene	analogues|compound|START_ENTITY analogues|nmod|inhibitors inhibitors|amod|END_ENTITY	Carbocyclic adenosine analogues as S-adenosylhomocysteine_hydrolase inhibitors and antiviral agents : recent advances .
16688763	0	adenosine	21,30	SLC29A1	54,61	adenosine	SLC29A1	MESH:D000241	2030	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Nitric_oxide reduces adenosine transporter ENT1 gene -LRB- SLC29A1 -RRB- promoter activity in human fetal endothelium from gestational diabetes .
18441046	0	adenosine	80,89	SRP72	109,114	adenosine	SRP72	MESH:D000241	6731	Chemical	Gene	START_ENTITY|nmod|the the|nmod|END_ENTITY	The 5e motif of eukaryotic signal recognition particle RNA contains a conserved adenosine for the binding of SRP72 .
18004767	0	adenosine	43,52	TNF-Alpha	11,20	adenosine	TNF-Alpha	MESH:D000241	7124	Chemical	Gene	START_ENTITY|nsubj|A2B A2B|compound|END_ENTITY	Short-term TNF-Alpha treatment induced A2B adenosine receptor desensitization in human astroglial cells .
10914495	0	adenosine	69,78	TNF-alpha	15,24	adenosine	TNF-alpha	MESH:D000241	7124	Chemical	Gene	inhibitor|amod|START_ENTITY Suppression|nmod|inhibitor Suppression|nmod|production production|amod|END_ENTITY	Suppression of TNF-alpha production in human mononuclear cells by an adenosine kinase inhibitor .
14728814	0	adenosine	23,32	TNF-alpha	73,82	adenosine	TNF-alpha	MESH:D000241	24835(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Pretreatment effect of adenosine on activation of NF-kappaB and level of TNF-alpha during myocardial_ischemia and reperfusion in rats .
15321739	0	adenosine	14,23	TNF-alpha	93,102	adenosine	TNF-alpha	MESH:D000241	7124	Chemical	Gene	receptors|amod|START_ENTITY Activation|nmod|receptors inhibits|nsubj|Activation inhibits|advcl|decreasing decreasing|dobj|stability stability|amod|END_ENTITY	Activation of adenosine receptors inhibits tumor_necrosis_factor-alpha release by decreasing TNF-alpha mRNA stability and p38 activity .
15704067	0	adenosine	20,29	TNF-alpha	53,62	adenosine	TNF-alpha	MESH:D000241	7124	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Upregulation of A2A adenosine receptor expression by TNF-alpha in PBMC of patients with CHF : a regulatory mechanism of inflammation .
15748700	0	adenosine	12,21	TNF-alpha	65,74	adenosine	TNF-alpha	MESH:D000241	7124	Chemical	Gene	A2A|amod|START_ENTITY role|nmod|A2A role|nmod|regulation regulation|nmod|production production|amod|END_ENTITY	The role of adenosine A2A and A2B receptors in the regulation of TNF-alpha production by human monocytes .
16322943	0	adenosine	22,31	TNF-alpha	0,9	adenosine	TNF-alpha	MESH:D000241	7124	Chemical	Gene	START_ENTITY|nmod:npmod|upregulates upregulates|nummod|END_ENTITY	TNF-alpha upregulates adenosine 2b -LRB- A2b -RRB- receptor expression and signaling in intestinal epithelial cells : a basis for A2bR overexpression in colitis .
16324785	0	adenosine	14,23	TNF-alpha	74,83	adenosine	TNF-alpha	MESH:D000241	7124	Chemical	Gene	receptor|amod|START_ENTITY Activation|nmod|receptor suppresses|nsubj|Activation suppresses|dobj|production production|amod|END_ENTITY	Activation of adenosine A3 receptor suppresses lipopolysaccharide-induced TNF-alpha production through inhibition of PI 3-kinase/Akt and NF-kappaB activation in murine BV2 microglial cells .
16778150	0	adenosine	4,13	TNF-alpha	83,92	adenosine	TNF-alpha	MESH:D000241	7124	Chemical	Gene	START_ENTITY|ccomp|induce induce|xcomp|resulting resulting|nmod|increase increase|amod|END_ENTITY	A2B adenosine receptors induce IL-19 from bronchial epithelial cells , resulting in TNF-alpha increase .
16849509	0	adenosine	4,13	TNF-alpha	55,64	adenosine	TNF-alpha	MESH:D000241	7124	Chemical	Gene	system|amod|START_ENTITY inhibits|nsubj|system inhibits|dobj|production production|amod|END_ENTITY	The adenosine system selectively inhibits TLR-mediated TNF-alpha production in the human newborn .
17321471	0	adenosine	12,21	TNF-alpha	58,67	adenosine	TNF-alpha	MESH:D000241	21926(Tax:10090)	Chemical	Gene	receptors|amod|START_ENTITY receptors|nmod|regulation regulation|nmod|production production|amod|END_ENTITY	The role of adenosine A -LRB- 2 -RRB- receptors in the regulation of TNF-alpha production and PGE -LRB- 2 -RRB- release in mouse peritoneal macrophages .
18647598	0	adenosine	30,39	TNF-alpha	0,9	adenosine	TNF-alpha	MESH:D000241	21926(Tax:10090)	Chemical	Gene	gene|amod|START_ENTITY upregulates|dep|gene upregulates|amod|END_ENTITY	TNF-alpha upregulates the A2B adenosine receptor gene : The role of NAD -LRB- P -RRB- H_oxidase_4 .
19047957	0	adenosine	77,86	TNF-alpha	19,28	adenosine	TNF-alpha	MESH:D000241	7124	Chemical	Gene	receptors|amod|START_ENTITY role|nmod|receptors modulates|parataxis|role modulates|dobj|production production|amod|END_ENTITY	Caffeine modulates TNF-alpha production by cord blood monocytes : the role of adenosine receptors .
8617970	0	adenosine	38,47	TNF-alpha	14,23	adenosine	TNF-alpha	MESH:D000241	7124	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Inhibition of TNF-alpha expression by adenosine : role of A3 adenosine receptors .
8617970	0	adenosine	60,69	TNF-alpha	14,23	adenosine	TNF-alpha	MESH:D000241	7124	Chemical	Gene	receptors|amod|START_ENTITY role|nmod|receptors Inhibition|dep|role Inhibition|nmod|expression expression|amod|END_ENTITY	Inhibition of TNF-alpha expression by adenosine : role of A3 adenosine receptors .
12875990	3	adenosine	580,589	VEGF	822,826	adenosine	VEGF	MESH:D000241	22339(Tax:10090)	Chemical	Gene	absence|nmod|START_ENTITY resiquimod|nmod|absence resiquimod|nmod|END_ENTITY	In the absence of adenosine or A -LRB- 2A -RRB- R agonists , Porphyromonas_gingivalis -LRB- P. _ gingivalis -RRB- LPS and PAM -LRB- 3 -RRB- CAG -LRB- TLR2 agonists -RRB- , resiquimod -LRB- R848 -RRB- -LRB- TLR7 agonist -RRB- , and non-methylated CpG DNA -LRB- TLR9 agonist -RRB- strongly up-regulate TNFalpha expression , with no effect on VEGF .
20543089	0	adenosine	80,89	VEGF	33,37	adenosine	VEGF	MESH:D000241	7422	Chemical	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|secretion secretion|nmod|END_ENTITY	Contraction-induced secretion of VEGF from skeletal muscle cells is mediated by adenosine .
26317647	0	adenosine	51,60	VEGF	78,82	adenosine	VEGF	MESH:D000241	22339(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY production|compound|END_ENTITY	Myeloid-derived suppressor cells contribute to A2B adenosine receptor-induced VEGF production and angiogenesis in a mouse melanoma model .
12713828	0	adenosine	18,27	adenosine_A2A_receptor	68,90	adenosine	adenosine A2A receptor	MESH:D000241	135	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	2,8-Disubstituted adenosine derivatives as partial agonists for the adenosine_A2A_receptor .
10069416	0	adenosine	109,118	adenosine_deaminase	149,168	adenosine	adenosine deaminase	MESH:D000241	100	Chemical	Gene	extracellular|nmod|START_ENTITY extracellular|nmod|END_ENTITY	The extracellular versus intracellular mechanisms of inhibition of TCR-triggered activation in thymocytes by adenosine under conditions of inhibited adenosine_deaminase .
10845921	0	adenosine	81,90	adenosine_deaminase	129,148	adenosine	adenosine deaminase	MESH:D000241	11486(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY receptor|dobj|effects receptor|nmod|conditions conditions|nmod|deficiency deficiency|amod|END_ENTITY	A -LRB- 2A -RRB- receptor dependent and A -LRB- 2A -RRB- receptor independent effects of extracellular adenosine on murine thymocytes in conditions of adenosine_deaminase deficiency .
12633906	0	adenosine	31,40	adenosine_deaminase	102,121	adenosine	adenosine deaminase	MESH:D000241	11486(Tax:10090)	Chemical	Gene	phosphorylase|compound|START_ENTITY phosphorylase|dep|development development|nmod|therapy therapy|nmod|deficiency deficiency|amod|END_ENTITY	Polyethylene_glycol-conjugated adenosine phosphorylase : development of alternative enzyme therapy for adenosine_deaminase deficiency .
1415780	0	adenosine	54,63	adenosine_deaminase	10,29	adenosine	adenosine deaminase	MESH:D000241	100720869	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of adenosine_deaminase on cardiac interstitial adenosine .
15458461	0	adenosine	17,26	adenosine_deaminase	64,83	adenosine	adenosine deaminase	MESH:D000241	100	Chemical	Gene	concentrations|amod|START_ENTITY study|nmod|concentrations study|nmod|END_ENTITY	Kinetic study of adenosine concentrations and the expression of adenosine_deaminase in mononuclear cells during hemodialysis .
15663892	0	adenosine	56,65	adenosine_deaminase	21,40	adenosine	adenosine deaminase	MESH:D000241	100	Chemical	Gene	receptors|amod|START_ENTITY function|nmod|receptors END_ENTITY|nmod|function	Modulating effect of adenosine_deaminase on function of adenosine A1 receptors .
16245692	0	adenosine	74,83	adenosine_deaminase	39,58	adenosine	adenosine deaminase	MESH:D000241	100	Chemical	Gene	analogues|amod|START_ENTITY complexes|nmod|analogues complexes|amod|END_ENTITY	-LSB- Theoretical study of the structure of adenosine_deaminase complexes with adenosine analogues : I. Aza - , deaza - and isomeric azadeazaanalogues of adenosine -RSB- .
16563876	0	adenosine	62,71	adenosine_deaminase	97,116	adenosine	adenosine deaminase	MESH:D000241	24165(Tax:10116)	Chemical	Gene	motoneurons|nmod|START_ENTITY motoneurons|nmod|role role|nmod|END_ENTITY	Fine-tuning modulation of myenteric motoneurons by endogenous adenosine : on the role of secreted adenosine_deaminase .
16670267	0	adenosine	40,49	adenosine_deaminase	86,105	adenosine	adenosine deaminase	MESH:D000241	100	Chemical	Gene	catabolism|nmod|START_ENTITY catabolism|dep|role role|nmod|END_ENTITY	Endothelial catabolism of extracellular adenosine during hypoxia : the role of surface adenosine_deaminase and CD26 .
1671090	0	adenosine	6,15	adenosine_deaminase	105,124	adenosine	adenosine deaminase	MESH:D000241	24165(Tax:10116)	Chemical	Gene	START_ENTITY|dep|effects effects|nmod|deoxycoformycin deoxycoformycin|amod|END_ENTITY	Brain adenosine and transmitter amino_acid release from the ischemic rat cerebral cortex : effects of the adenosine_deaminase inhibitor deoxycoformycin .
17727332	0	adenosine	18,27	adenosine_deaminase	106,125	adenosine	adenosine deaminase	MESH:D000241	11486(Tax:10090)	Chemical	Gene	Role|nmod|START_ENTITY Role|dep|generation generation|acl|signaling signaling|nmod|CD26 CD26|compound|END_ENTITY	Role of pulmonary adenosine during hypoxia : extracellular generation , signaling and metabolism by surface adenosine_deaminase / CD26 .
18173230	0	adenosine	50,59	adenosine_deaminase	14,33	adenosine	adenosine deaminase	MESH:D000241	280712(Tax:9913)	Chemical	Gene	analogues|nmod|START_ENTITY Inhibition|nmod|analogues Inhibition|nmod|END_ENTITY	Inhibition of adenosine_deaminase by analogues of adenosine and inosine , incorporating a common heterocyclic base , 4 -LRB- 7 -RRB- - amino-6 -LRB- 5 -RRB- H-imidazo -LSB- 4,5-d -RSB- pyridazin-7 -LRB- 4 -RRB- one .
18188767	0	adenosine	59,68	adenosine_deaminase	12,31	adenosine	adenosine deaminase	MESH:D000241	280712(Tax:9913)	Chemical	Gene	deaminase|nmod|START_ENTITY deaminase|nsubj|Activity Activity|nmod|END_ENTITY	Activity of adenosine_deaminase and adenylate deaminase on adenosine and 2 ' , _ 3 -LRB- ' -RRB- - isopropylidene_adenosine : role of the protecting group at different pH values .
1898656	1	adenosine	102,111	adenosine_deaminase	162,181	adenosine	adenosine deaminase	MESH:D000241	100	Chemical	Gene	accumulation|nmod|START_ENTITY accumulation|acl|owing owing|nmod|inactivation inactivation|nmod|END_ENTITY	Phorbol_myristate_acetate-induced accumulation of adenosine owing to inactivation of extracellularly released adenosine_deaminase .
19934879	0	adenosine	38,47	adenosine_deaminase	82,101	adenosine	adenosine deaminase	MESH:D000241	24165(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY decreases|nmod|levels reversed|nsubjpass|decreases reversed|advcl|inhibiting inhibiting|dobj|END_ENTITY	Opioid-induced decreases in rat brain adenosine levels are reversed by inhibiting adenosine_deaminase .
20668053	0	adenosine	104,113	adenosine_deaminase	16,35	adenosine	adenosine deaminase	MESH:D000241	24165(Tax:10116)	Chemical	Gene	A2A|amod|START_ENTITY recruitment|nmod|A2A ameliorates|nmod|recruitment ameliorates|nsubj|blockade blockade|nmod|END_ENTITY	The blockade of adenosine_deaminase ameliorates chronic experimental colitis through the recruitment of adenosine A2A and A3 receptors .
2090926	0	adenosine	35,44	adenosine_deaminase	3,22	adenosine	adenosine deaminase	MESH:D000241	100	Chemical	Gene	transport|amod|START_ENTITY involved|nmod|transport involved|nsubjpass|END_ENTITY	Is adenosine_deaminase involved in adenosine transport ?
20940317	0	adenosine	24,33	adenosine_deaminase	70,89	adenosine	adenosine deaminase	MESH:D000241	41092(Tax:7227)	Chemical	Gene	START_ENTITY|nmod|Drosophila Drosophila|acl:relcl|deficient deficient|nmod|END_ENTITY	Increased extracellular adenosine in Drosophila that are deficient in adenosine_deaminase activates a release of energy stores leading to wasting and death .
21306300	0	adenosine	4,13	adenosine_deaminase	84,103	adenosine	adenosine deaminase	MESH:D000241	100	Chemical	Gene	ligand|amod|START_ENTITY modulated|nsubjpass|ligand modulated|nmod|END_ENTITY	A2A adenosine receptor ligand binding and signalling is allosterically modulated by adenosine_deaminase .
2260506	2	adenosine	61,70	adenosine_deaminase	163,182	adenosine	adenosine deaminase	MESH:D000241	100625920	Chemical	Gene	analogues|amod|START_ENTITY Effects|nmod|analogues free|nsubj|Effects free|nmod|pigs pigs|acl|representing representing|dobj|activity activity|amod|END_ENTITY	Effects of adenosine analogues on plasma free fatty_acids , glucose and lactate in pigs representing high and low adenosine_deaminase red cell activity .
23193172	0	adenosine	101,110	adenosine_deaminase	38,57	adenosine	adenosine deaminase	MESH:D000241	100	Chemical	Gene	binding|xcomp|START_ENTITY ligand|xcomp|binding ligand|nsubj|gate gate|nmod|modulates modulates|amod|END_ENTITY	The catalytic site structural gate of adenosine_deaminase allosterically modulates ligand binding to adenosine receptors .
2324961	0	adenosine	79,88	adenosine_deaminase	176,195	adenosine	adenosine deaminase	MESH:D000241	100	Chemical	Gene	derivatives|amod|START_ENTITY characteristics|nmod|derivatives study|nmod|characteristics study|dep|implications implications|nmod|mechanism mechanism|nmod|reaction reaction|nmod|END_ENTITY	Quantum chemical study of the electronic and conformational characteristics of adenosine and 8-substituted derivatives : functional implications in the mechanism of reaction of adenosine_deaminase .
23462984	0	adenosine	53,62	adenosine_deaminase	24,43	adenosine	adenosine deaminase	MESH:D000241	100	Chemical	Gene	self-assembly|amod|START_ENTITY based|nmod|self-assembly based|nsubj|sensing sensing|nmod|END_ENTITY	Fluorescence sensing of adenosine_deaminase based on adenosine induced self-assembly of aptamer structures .
2357554	0	adenosine	77,86	adenosine_deaminase	11,30	adenosine	adenosine deaminase	MESH:D000241	100	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|inhibition inhibition|amod|END_ENTITY	Effects of adenosine_deaminase inhibition on active uptake and metabolism of adenosine in astrocytes in primary cultures .
24288262	0	adenosine	99,108	adenosine_deaminase	65,84	adenosine	adenosine deaminase	MESH:D000241	100	Chemical	Gene	analogue|amod|START_ENTITY transforms|dobj|analogue END_ENTITY|dep|transforms	Enzymatic interconversion of isomorphic fluorescent nucleosides : adenosine_deaminase transforms an adenosine analogue into an inosine analogue .
2459496	0	adenosine	24,33	adenosine_deaminase	53,72	adenosine	adenosine deaminase	MESH:D000241	100	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|deficiency deficiency|amod|END_ENTITY	Substrate inhibition of adenosine phosphorylation in adenosine_deaminase deficiency and adenosine-mediated inhibition of PP-ribose-P dependent nucleotide synthesis in hypoxanthine_phosphoribosyltransferase_deficient erythrocytes .
2502780	0	adenosine	108,117	adenosine_deaminase	11,30	adenosine	adenosine deaminase	MESH:D000241	24165(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY test|nmod|role interventions|dep|test interventions|compound|END_ENTITY	Short-time adenosine_deaminase interventions upon underperfused rat hearts in vitro -- a test for the role of adenosine in the coronary flow control .
25210228	0	adenosine	98,107	adenosine_deaminase	52,71	adenosine	adenosine deaminase	MESH:D000241	24165(Tax:10116)	Chemical	Gene	neuromodulation|amod|START_ENTITY loss|nmod|neuromodulation contribute|nmod|loss contribute|nsubj|inhibition inhibition|nmod|CD73 CD73|nmod|END_ENTITY	Feed-forward inhibition of CD73 and upregulation of adenosine_deaminase contribute to the loss of adenosine neuromodulation in postinflammatory_ileitis .
2537460	0	adenosine	60,69	adenosine_deaminase	174,193	adenosine	adenosine deaminase	MESH:D000241	100	Chemical	Gene	protonation|nmod|START_ENTITY study|nmod|protonation study|dep|implications implications|nmod|mechanism mechanism|nmod|reaction reaction|nmod|END_ENTITY	Theoretical study of the protonation and tautomerization of adenosine , formycin , and their 2-NH2 and 2-F derivatives : functional implications in the mechanism of reaction of adenosine_deaminase .
2812252	0	adenosine	82,91	adenosine_deaminase	14,33	adenosine	adenosine deaminase	MESH:D000241	100	Chemical	Gene	transport|nmod|START_ENTITY reveals|dobj|transport reveals|nsubj|Inhibition Inhibition|nmod|activity activity|amod|END_ENTITY	Inhibition of adenosine_deaminase activity reveals an intense active transport of adenosine into neurons in primary cultures .
3003627	0	adenosine	133,142	adenosine_deaminase	66,85	adenosine	adenosine deaminase	MESH:D000241	100	Chemical	Gene	role|nmod|START_ENTITY evidence|nmod|role Enhancement|dep|evidence Enhancement|nmod|transmission transmission|nmod|junction junction|nmod|END_ENTITY	Enhancement of transmission at the frog neuromuscular junction by adenosine_deaminase : evidence for an inhibitory role of endogenous adenosine on neuromuscular transmission .
3265122	0	adenosine	15,24	adenosine_deaminase	42,61	adenosine	adenosine deaminase	MESH:D000241	24165(Tax:10116)	Chemical	Gene	Degradation|nmod|START_ENTITY END_ENTITY|nsubj|Degradation	Degradation of adenosine by extracellular adenosine_deaminase in the rat duodenum .
3596088	0	adenosine	43,52	adenosine_deaminase	122,141	adenosine	adenosine deaminase	MESH:D000241	100	Chemical	Gene	Evidence|nmod|START_ENTITY Evidence|parataxis|induction induction|dep|outgrowth outgrowth|nmod|END_ENTITY	Evidence for negative control of growth by adenosine in the mammalian embryo : induction of Hmx / + mutant limb outgrowth by adenosine_deaminase .
3916912	0	adenosine	79,88	adenosine_deaminase	14,33	adenosine	adenosine deaminase	MESH:D000241	280712(Tax:9913)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of adenosine_deaminase from several sources by deaza derivatives of adenosine and EHNA .
4795749	0	adenosine	33,42	adenosine_deaminase	86,105	adenosine	adenosine deaminase	MESH:D000241	100	Chemical	Gene	induced|nmod|START_ENTITY starvation|acl|induced starvation|dep|role role|nmod|END_ENTITY	Pyrimidine starvation induced by adenosine in fibroblasts and lymphoid cells : role of adenosine_deaminase .
6142530	0	adenosine	62,71	adenosine_deaminase	24,43	adenosine	adenosine deaminase	MESH:D000241	24165(Tax:10116)	Chemical	Gene	neurotransmission|amod|START_ENTITY implications|nmod|neurotransmission Immunohistochemistry|dep|implications Immunohistochemistry|nmod|END_ENTITY	Immunohistochemistry of adenosine_deaminase : implications for adenosine neurotransmission .
647708	0	adenosine	93,102	adenosine_deaminase	43,62	adenosine	adenosine deaminase	MESH:D000241	100	Chemical	Gene	immobilisation|nmod|START_ENTITY obtained|nmod|immobilisation obtained|nsubj|resins resins|nmod|END_ENTITY	Substrate - and product-affinity resins for adenosine_deaminase obtained by immobilisation of adenosine and inosine via 2 ' ,3 ' - cyclic_acetal derivatives .
7103613	0	adenosine	42,51	adenosine_deaminase	107,126	adenosine	adenosine deaminase	MESH:D000241	100720869	Chemical	Gene	actions|nmod|START_ENTITY Potentiation|nmod|actions Potentiation|nmod|presence presence|nmod|coformycin coformycin|appos|inhibitor inhibitor|nmod|END_ENTITY	Potentiation of the myocardial actions of adenosine in the presence of coformycin , a specific inhibitor of adenosine_deaminase .
7184903	0	adenosine	58,67	adenosine_deaminase	14,33	adenosine	adenosine deaminase	MESH:D000241	100	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of adenosine_deaminase by deaza derivatives of adenosine and purine_riboside .
7575376	0	adenosine	56,65	adenosine_deaminase	14,33	adenosine	adenosine deaminase	MESH:D000241	477236(Tax:9615)	Chemical	Gene	hypoxia|amod|START_ENTITY END_ENTITY|nmod|hypoxia	Inhibition of adenosine_deaminase and administration of adenosine increase hypoxia induced ventricular_ectopy .
7633332	0	adenosine	84,93	adenosine_deaminase	15,34	adenosine	adenosine deaminase	MESH:D000241	24165(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY regulating|dobj|concentration END_ENTITY|advcl|regulating	Involvement of adenosine_deaminase and adenosine_kinase in regulating extracellular adenosine concentration in rat hippocampal slices .
8189039	0	adenosine	126,135	adenosine_deaminase	28,47	adenosine	adenosine deaminase	MESH:D000241	100346236(Tax:9986)	Chemical	Gene	metabolism|amod|START_ENTITY implications|nmod|metabolism distribution|dep|implications distribution|nmod|END_ENTITY	Subcellular distribution of adenosine_deaminase and adenosine_deaminase-complexing_protein in rabbit kidney : implications for adenosine metabolism .
8616636	0	adenosine	14,23	adenosine_deaminase	56,75	adenosine	adenosine deaminase	MESH:D000241	24165(Tax:10116)	Chemical	Gene	Modulation|nmod|START_ENTITY release|nsubj|Modulation release|nmod|cord cord|nmod|inhibitors inhibitors|amod|END_ENTITY	Modulation of adenosine release from rat spinal cord by adenosine_deaminase and adenosine kinase inhibitors .
8846098	0	adenosine	62,71	adenosine_deaminase	75,94	adenosine	adenosine deaminase	MESH:D000241	24165(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|amod|END_ENTITY	Enhancement of NMDA-induced increases in levels of endogenous adenosine by adenosine_deaminase and adenosine transport inhibition in rat striatum .
9399998	0	adenosine	14,23	adenosine_deaminase	85,104	adenosine	adenosine deaminase	MESH:D000241	24165(Tax:10116)	Chemical	Gene	concentration|amod|START_ENTITY concentration|nmod|END_ENTITY	Regulation of adenosine concentration and cytoprotective effects of novel reversible adenosine_deaminase inhibitors .
4705139	0	adenosine	49,58	adenyl_cyclase	20,34	adenosine	adenyl cyclase	MESH:D000241	107	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	On the mechanism of adenyl_cyclase inhibition by adenosine .
1714001	0	adenosine	35,44	angiotensin_II	10,24	adenosine	angiotensin II	MESH:D000241	24179(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of angiotensin_II on plasma adenosine concentrations in the rat .
11515749	0	adenosine	62,71	cholecystokinin_B_receptor	27,53	adenosine	cholecystokinin B receptor	MESH:D000241	887	Chemical	Gene	START_ENTITY|nsubj|studies studies|nmod|END_ENTITY	Association studies of the cholecystokinin_B_receptor and A2a adenosine receptor genes in panic_disorder .
12119284	0	adenosine	89,98	connexin_43	39,50	adenosine	connexin 43	MESH:D000241	2697	Chemical	Gene	expressing|advcl|START_ENTITY expressing|dobj|permselectivity permselectivity|amod|END_ENTITY	Gap junctions between cells expressing connexin_43 or 32 show inverse permselectivity to adenosine and ATP .
23834776	0	adenosine	25,34	connexin_43	44,55	adenosine	connexin 43	MESH:D000241	2697	Chemical	Gene	effect|nmod|START_ENTITY involves|nsubj|effect involves|dobj|turn-over turn-over|amod|END_ENTITY	Antiadrenergic effect of adenosine involves connexin_43 turn-over in H9c2 cells .
17552497	0	adenosine	83,92	cyclophilin	43,54	adenosine	cyclophilin	MESH:D000241	13391647	Chemical	Gene	kinase|amod|START_ENTITY END_ENTITY|nmod|kinase	Amino_acid residues of Leishmania_donovani cyclophilin key to interaction with its adenosine kinase : biological implications .
22787201	0	adenosine	97,106	cystatin_A	78,88	adenosine	cystatin A	MESH:D000241	1475	Chemical	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	Imiquimod suppresses propagation of herpes_simplex_virus_1 by upregulation of cystatin_A via the adenosine receptor A1 pathway .
10591151	0	adenosine	11,20	dopamine_D3_receptor	59,79	adenosine	dopamine D3 receptor	MESH:D000241	29238(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|agonist agonist|amod|END_ENTITY	Effects of adenosine A -LRB- 2A -RRB- receptor stimulation in vivo on dopamine_D3_receptor agonist binding in the rat brain .
10694229	0	adenosine	140,149	endothelin-1	52,64	adenosine	endothelin-1	MESH:D000241	100726197	Chemical	Gene	receptors|amod|START_ENTITY inhibits|nmod|receptors inhibits|dobj|production/secretion production/secretion|amod|END_ENTITY	Adenosine induces cyclic-AMP formation and inhibits endothelin-1 production/secretion in guinea-pig tracheal epithelial cells through A -LRB- 2B -RRB- adenosine receptors .
16733909	0	adenosine	11,20	endothelin-1	24,36	adenosine	endothelin-1	MESH:D000241	396915(Tax:9823)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of adenosine on endothelin-1 in the infarcted reflow and no-reflow_myocardium of mini-swine -RSB- .
18664027	0	adenosine	12,21	endothelin-1	65,77	adenosine	endothelin-1	MESH:D000241	396915(Tax:9823)	Chemical	Gene	reduces|advmod|START_ENTITY reduces|advcl|decreasing decreasing|dobj|END_ENTITY	Intravenous adenosine reduces myocardial no-reflow by decreasing endothelin-1 via activation of the ATP-sensitive K + channel .
22409811	0	adenosine	111,120	endothelin-1	27,39	adenosine	endothelin-1	MESH:D000241	13614(Tax:10090)	Chemical	Gene	transporter|amod|START_ENTITY expression|nmod|transporter effect|nmod|expression injection|dep|effect injection|nmod|infarcts infarcts|amod|END_ENTITY	Intracortical injection of endothelin-1 induces cortical infarcts in mice : effect of neuronal expression of an adenosine transporter .
8523458	0	adenosine	48,57	endothelin-1	10,22	adenosine	endothelin-1	MESH:D000241	24323(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of endothelin-1 and its combination with adenosine on myocardial contractility and myocardial energy metabolism in vivo .
19801629	0	adenosine	79,88	equilibrative_nucleoside_transporter_1	18,56	adenosine	equilibrative nucleoside transporter 1	MESH:D000241	63997(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY END_ENTITY|nmod|receptors	Inhibition of the equilibrative_nucleoside_transporter_1 and activation of A2A adenosine receptors by 8 - -LRB- 4-chlorophenylthio -RRB- - modified cAMP analogs and their hydrolytic products .
17855480	0	adenosine	32,41	erythropoietin	76,90	adenosine	erythropoietin	MESH:D000241	13856(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Lack of effect of extracellular adenosine generation and signaling on renal erythropoietin secretion during hypoxia .
3397622	0	adenosine	43,52	erythropoietin	14,28	adenosine	erythropoietin	MESH:D000241	24335(Tax:10116)	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|production production|compound|END_ENTITY	Modulation of erythropoietin production by adenosine .
3398696	0	adenosine	10,19	erythropoietin	43,57	adenosine	erythropoietin	MESH:D000241	13856(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|regulation regulation|nmod|production production|compound|END_ENTITY	A1 and A2 adenosine receptor regulation of erythropoietin production .
8393698	0	adenosine	50,59	erythropoietin	13,27	adenosine	erythropoietin	MESH:D000241	2056	Chemical	Gene	-RSB-|amod|START_ENTITY mediated|nmod|-RSB- secretion|acl|mediated secretion|compound|END_ENTITY	-LSB- Increase in erythropoietin secretion mediated by adenosine A2 receptors -RSB- .
8761029	0	adenosine	53,62	erythropoietin	14,28	adenosine	erythropoietin	MESH:D000241	24335(Tax:10116)	Chemical	Gene	agonists|compound|START_ENTITY Modulation|nmod|agonists Modulation|nmod|production production|compound|END_ENTITY	Modulation of erythropoietin production by selective adenosine agonists and antagonists in normal and anemic rats .
17301835	0	adenosine	68,77	fibroblast_growth_factor-7	21,47	adenosine	fibroblast growth factor-7	MESH:D000241	2252	Chemical	Gene	receptor|amod|START_ENTITY expression|nmod|receptor expression|amod|END_ENTITY	Adenosine stimulates fibroblast_growth_factor-7 gene expression via adenosine A2b receptor signaling in dermal papilla cells .
10233112	0	adenosine	46,55	growth_factor	86,99	adenosine	growth factor	MESH:D000241	79215(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effect of NO , vasodilator prostaglandins , and adenosine on skeletal muscle angiogenic growth_factor gene expression .
14701834	0	adenosine	104,113	hCNT1	117,122	adenosine	hCNT1	MESH:D000241	9154	Chemical	Gene	START_ENTITY|nmod|function function|amod|END_ENTITY	Electrophysiological characterization of the human Na -LRB- + -RRB- / nucleoside_cotransporter_1 -LRB- hCNT1 -RRB- and role of adenosine on hCNT1 function .
24924894	0	adenosine	12,21	hMLH1	25,30	adenosine	hMLH1	MESH:D000241	4292	Chemical	Gene	START_ENTITY|nmod|methylation methylation|amod|END_ENTITY	-LSB- Effects of adenosine on hMLH1 methylation of human colorectal_cancer cells -RSB- .
11433005	0	adenosine	14,23	insulin	37,44	adenosine	insulin	MESH:D000241	3630	Chemical	Gene	transport|amod|START_ENTITY transport|nmod|END_ENTITY	Modulation of adenosine transport by insulin in human umbilical artery smooth muscle cells from normal or gestational diabetic_pregnancies .
7008370	0	adenosine	26,35	insulin_and_glucagon_release	48,76	adenosine	insulin and glucagon release	MESH:D000241	483665(Tax:9615)	Chemical	Gene	analogue|compound|START_ENTITY analogue|nmod|END_ENTITY	-LSB- Effects of a long-acting adenosine analogue on insulin_and_glucagon_release -LRB- author 's transl -RRB- -RSB- .
10101031	0	adenosine	105,114	interleukin-8	137,150	adenosine	interleukin-8	MESH:D000241	3576	Chemical	Gene	production|amod|START_ENTITY production|amod|END_ENTITY	Role of p38 mitogen-activated protein kinase and extracellular signal-regulated protein kinase kinase in adenosine A2B receptor-mediated interleukin-8 production in human mast cells .
6186849	0	adenosine	86,95	islet-activating_protein	16,40	adenosine	islet-activating protein	MESH:D000241	29364(Tax:10116)	Chemical	Gene	actions|nmod|START_ENTITY END_ENTITY|nmod|actions	Modification by islet-activating_protein of direct and indirect inhibitory actions of adenosine on rat atrial contraction in relation to cyclic nucleotide metabolism .
10615945	0	adenosine	8,17	leptin	51,57	adenosine	leptin	MESH:D000241	25608(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of adenosine in insulin-stimulated release of leptin from isolated white adipocytes of Wistar_rats .
16872559	0	adenosine	50,59	leptin	10,16	adenosine	leptin	MESH:D000241	16846(Tax:10090)	Chemical	Gene	administration|nmod|START_ENTITY administration|compound|END_ENTITY	Effect of leptin administration on membrane-bound adenosine triphosphatase activity in ethanol-induced experimental liver toxicity .
14985075	0	adenosine	22,31	mENT1	45,50	adenosine	mENT1	MESH:D000241	63959(Tax:10090)	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Hypoxia regulates the adenosine transporter , mENT1 , in the murine cardiomyocyte cell line , HL-1 .
15131243	0	adenosine	4,13	mENT1	27,32	adenosine	mENT1	MESH:D000241	63959(Tax:10090)	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	The adenosine transporter , mENT1 , is a target for adenosine receptor signaling and protein_kinase_Cepsilon in hypoxic and pharmacological preconditioning in the mouse cardiomyocyte cell line , HL-1 .
15131243	0	adenosine	50,59	mENT1	27,32	adenosine	mENT1	MESH:D000241	63959(Tax:10090)	Chemical	Gene	signaling|amod|START_ENTITY target|nmod|signaling target|nsubj|transporter transporter|appos|END_ENTITY	The adenosine transporter , mENT1 , is a target for adenosine receptor signaling and protein_kinase_Cepsilon in hypoxic and pharmacological preconditioning in the mouse cardiomyocyte cell line , HL-1 .
23388705	0	adenosine	16,25	mENT1	191,196	adenosine	mENT1	MESH:D000241	63959(Tax:10090)	Chemical	Gene	agonist|amod|START_ENTITY Transport|nmod|agonist Transport|dep|evidence evidence|nmod|transport transport|nmod|END_ENTITY	Transport of A1 adenosine receptor agonist tecadenoson by human and mouse nucleoside transporters : evidence for blood-brain barrier transport by murine equilibrative nucleoside transporter 1 mENT1 .
126449	0	adenosine	89,98	myosin	126,132	adenosine	myosin	MESH:D000241	79784	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Oxygen exchange in the gamma-phosphoryl group of protein-bound ATP during Mg2 + - dependent adenosine triphosphatase activity of myosin .
4263190	0	adenosine	53,62	myosin	46,52	adenosine	myosin	MESH:D000241	79784	Chemical	Gene	START_ENTITY|nsubj|properties properties|nmod|END_ENTITY	The enzymic properties of a modified ox heart myosin adenosine triphosphatase on covalent binding to an insoluble cellulose matrix .
6449491	0	adenosine	25,34	myosin	18,24	adenosine	myosin	MESH:D000241	396902(Tax:9823)	Chemical	Gene	START_ENTITY|nsubj|sensitivity sensitivity|nmod|END_ENTITY	pH sensitivity of myosin adenosine triphosphatase and subtypes of myofibres in porcine muscle .
17135404	0	adenosine	52,61	p38_mitogen-activated_protein_kinase	0,36	adenosine	p38 mitogen-activated protein kinase	MESH:D000241	81649(Tax:10116)	Chemical	Gene	contributes|xcomp|START_ENTITY contributes|nsubj|END_ENTITY	p38_mitogen-activated_protein_kinase contributes to adenosine A1 receptor-mediated synaptic_depression in area CA1 of the rat hippocampus .
22759956	0	adenosine	47,56	p53	69,72	adenosine	p53	MESH:D000241	7157	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	AMP converted from intracellularly transported adenosine upregulates p53 expression to induce malignant_pleural_mesothelioma cell apoptosis .
10531399	0	adenosine	59,68	p75	10,13	adenosine	p75	MESH:D000241	24596(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	A role of p75 in NGF-mediated down-regulation of the A -LRB- 2A -RRB- adenosine receptors in PC12 cells .
12131928	0	adenosine	23,32	prolactin	36,45	adenosine	prolactin	MESH:D000241	24683(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|secretion secretion|compound|END_ENTITY	Stimulatory effects of adenosine on prolactin secretion in the pituitary gland of the rat .
2770981	0	adenosine	19,28	prolactin	55,64	adenosine	prolactin	MESH:D000241	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|nmod|END_ENTITY	Central actions of adenosine on pituitary secretion of prolactin , luteinizing hormone and thyrotropin .
3003588	0	adenosine	35,44	prolactin	22,31	adenosine	prolactin	MESH:D000241	24683(Tax:10116)	Chemical	Gene	analogs|amod|START_ENTITY Increase|nmod|analogs Increase|nmod|END_ENTITY	Increase of rat serum prolactin by adenosine analogs and their blockade by the methylxanthine_aminophylline .
8148040	0	adenosine	17,26	prolactin	30,39	adenosine	prolactin	MESH:D000241	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Direct effect of adenosine on prolactin secretion at the level of the single rat lactotroph : involvement of pertussis toxin-sensitive and - insensitive transducing mechanisms .
11299275	0	adenosine	51,60	renin	18,23	adenosine	renin	MESH:D000241	403838(Tax:9615)	Chemical	Gene	START_ENTITY|nsubj|decrease decrease|compound|END_ENTITY	Evidence that the renin decrease during hypoxia is adenosine mediated in conscious dogs .
200064	0	adenosine	10,19	renin	45,50	adenosine	renin	MESH:D000241	5972	Chemical	Gene	compounds|amod|START_ENTITY Effect|nmod|compounds Effect|nmod|release release|compound|END_ENTITY	Effect of adenosine compounds -LRB- ATP , cAMP -RRB- on renin release in vitro .
2407369	0	adenosine	11,20	renin	31,36	adenosine	renin	MESH:D000241	24715(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|release release|compound|END_ENTITY	Endogenous adenosine restrains renin release in conscious rats .
2651649	0	adenosine	11,20	renin	31,36	adenosine	renin	MESH:D000241	24715(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|release release|compound|END_ENTITY	Endogenous adenosine restrains renin release during sodium restriction .
2983063	0	adenosine	10,19	renin	64,69	adenosine	renin	MESH:D000241	24715(Tax:10116)	Chemical	Gene	START_ENTITY|ccomp|inhibits inhibits|dobj|secretion secretion|compound|END_ENTITY	A1 and A2 adenosine receptor activation inhibits and stimulates renin secretion of rat renal cortical slices .
2997277	0	adenosine	17,26	renin	60,65	adenosine	renin	MESH:D000241	100358545(Tax:9986)	Chemical	Gene	START_ENTITY|nmod|mechanism mechanism|nmod|END_ENTITY	Possible role of adenosine in the macula densa mechanism of renin release in rabbits .
3027486	0	adenosine	25,34	renin	67,72	adenosine	renin	MESH:D000241	24715(Tax:10116)	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|secretion secretion|compound|END_ENTITY	Pertussis toxin reverses adenosine receptor-mediated inhibition of renin secretion in rat renal cortical slices .
3034778	0	adenosine	44,53	renin	14,19	adenosine	renin	MESH:D000241	100358545(Tax:9986)	Chemical	Gene	slices|amod|START_ENTITY analogues|nmod|slices release|nmod|analogues release|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of renin release by analogues of adenosine in rabbit renal cortical slices .
3328570	0	adenosine	70,79	renin	112,117	adenosine	renin	MESH:D000241	24715(Tax:10116)	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|secretion secretion|compound|END_ENTITY	XAC , a functionalized congener of 1,3-dialkylxanthine , antagonizes A1 adenosine receptor-mediated inhibition of renin secretion in vitro .
3330576	0	adenosine	19,28	renin	51,56	adenosine	renin	MESH:D000241	24715(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|modulator modulator|nmod|response response|compound|END_ENTITY	Role of endogenous adenosine as a modulator of the renin response to salt restriction .
3903010	0	adenosine	156,165	renin	20,25	adenosine	renin	MESH:D000241	403838(Tax:9615)	Chemical	Gene	promoted|nmod|START_ENTITY promoted|nsubj|Influence Influence|nmod|content content|compound|END_ENTITY	Influence of plasma renin content , intrarenal angiotensin II , captopril , and calcium channel blockers on the vasoconstriction and renin release promoted by adenosine in the kidney .
7485531	0	adenosine	13,22	renin	76,81	adenosine	renin	MESH:D000241	24715(Tax:10116)	Chemical	Gene	antagonism|compound|START_ENTITY augments|nsubj|antagonism augments|dobj|release release|compound|END_ENTITY	Selective A1 adenosine receptor antagonism augments beta-adrenergic-induced renin release in vivo .
8234540	0	adenosine	10,19	renin	39,44	adenosine	renin	MESH:D000241	24715(Tax:10116)	Chemical	Gene	blockade|amod|START_ENTITY Effect|nmod|blockade Effect|nmod|activity activity|compound|END_ENTITY	Effect of adenosine blockade on plasma renin activity and catecholamines .
8368332	0	adenosine	11,20	renin	64,69	adenosine	renin	MESH:D000241	100358545(Tax:9986)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of adenosine and angiotensin on macula densa-stimulated renin secretion .
25587035	0	adenosine	9,18	sphingosine_kinase_1	94,114	adenosine	sphingosine kinase 1	MESH:D000241	8877	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|activity activity|amod|END_ENTITY	Elevated adenosine signaling via adenosine A2B receptor induces normal and sickle erythrocyte sphingosine_kinase_1 activity in human and mice .
25561440	0	adenosine	56,65	thrombospondin-1	85,101	adenosine	thrombospondin-1	MESH:D000241	487486(Tax:9615)	Chemical	Gene	START_ENTITY|nmod|stimulation stimulation|nmod|END_ENTITY	Editorial : Old dog , new tricks : proangiogenic effect of adenosine via stimulation of thrombospondin-1 in macrophages .
7702564	0	adenosine	61,70	thyrotropin_receptor	33,53	adenosine	thyrotropin receptor	MESH:D000241	7253	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Intracellular cross-talk between thyrotropin_receptor and A1 adenosine receptor in regulation of phospholipase C and adenylate cyclase in COS-7 cells transfected with their receptor genes .
7788449	0	adenosine	13,22	tumor_necrosis_factor	38,59	adenosine	tumor necrosis factor	MESH:D000241	7124	Chemical	Gene	Activity|nmod|START_ENTITY Activity|nmod|END_ENTITY	-LSB- Activity of adenosine in relation to tumor_necrosis_factor -LRB- TNF -RRB- .
11752117	0	adenosine	12,21	tumor_necrosis_factor-alpha	78,105	adenosine	tumor necrosis factor-alpha	MESH:D000241	21926(Tax:10090)	Chemical	Gene	uptake|amod|START_ENTITY inhibitor|amod|uptake KF24345|appos|inhibitor suppresses|nsubj|KF24345 suppresses|dobj|production production|amod|END_ENTITY	KF24345 , an adenosine uptake inhibitor , suppresses lipopolysaccharide-induced tumor_necrosis_factor-alpha production and leukopenia via endogenous adenosine in mice .
11752117	0	adenosine	147,156	tumor_necrosis_factor-alpha	78,105	adenosine	tumor necrosis factor-alpha	MESH:D000241	21926(Tax:10090)	Chemical	Gene	suppresses|nmod|START_ENTITY suppresses|dobj|production production|amod|END_ENTITY	KF24345 , an adenosine uptake inhibitor , suppresses lipopolysaccharide-induced tumor_necrosis_factor-alpha production and leukopenia via endogenous adenosine in mice .
15321739	0	adenosine	14,23	tumor_necrosis_factor-alpha	43,70	adenosine	tumor necrosis factor-alpha	MESH:D000241	7124	Chemical	Gene	receptors|amod|START_ENTITY Activation|nmod|receptors inhibits|nsubj|Activation inhibits|dobj|release release|amod|END_ENTITY	Activation of adenosine receptors inhibits tumor_necrosis_factor-alpha release by decreasing TNF-alpha mRNA stability and p38 activity .
19703146	0	adenosine	11,20	tumor_necrosis_factor-alpha	64,91	adenosine	tumor necrosis factor-alpha	MESH:D000241	7124	Chemical	Gene	START_ENTITY|dobj|production production|amod|END_ENTITY	Endogenous adenosine down-modulates mid-trimester intraamniotic tumor_necrosis_factor-alpha production .
7665975	0	adenosine	25,34	tumor_necrosis_factor-alpha	62,89	adenosine	tumor necrosis factor-alpha	MESH:D000241	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|nmod|END_ENTITY	Acting via A2 receptors , adenosine inhibits the production of tumor_necrosis_factor-alpha of endotoxin-stimulated human polymorphonuclear leukocytes .
10869376	0	adenosine	77,86	vascular_endothelial_growth_factor	19,53	adenosine	vascular endothelial growth factor	MESH:D000241	83785(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY expression|nmod|receptor expression|compound|END_ENTITY	Down-regulation of vascular_endothelial_growth_factor expression after A -LRB- 2A -RRB- adenosine receptor activation in PC12 pheochromocytoma cells .
12590138	0	adenosine	110,119	vascular_endothelial_growth_factor	57,91	adenosine	vascular endothelial growth factor	MESH:D000241	83785(Tax:10116)	Chemical	Gene	activation|amod|START_ENTITY mediate|nmod|activation mediate|dobj|regulation regulation|nmod|expression expression|compound|END_ENTITY	Distinct protein kinase C isoforms mediate regulation of vascular_endothelial_growth_factor expression by A2A adenosine receptor activation and phorbol_esters in pheochromocytoma PC12 cells .
19712927	0	adenosine	66,75	vascular_endothelial_growth_factor	17,51	adenosine	vascular endothelial growth factor	MESH:D000241	83785(Tax:10116)	Chemical	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|expression expression|compound|END_ENTITY	Up-regulation of vascular_endothelial_growth_factor expression by adenosine through adenosine A2 receptors in the rat tongue treated with endotoxin .
19712927	0	adenosine	84,93	vascular_endothelial_growth_factor	17,51	adenosine	vascular endothelial growth factor	MESH:D000241	83785(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY Up-regulation|nmod|receptors Up-regulation|nmod|expression expression|compound|END_ENTITY	Up-regulation of vascular_endothelial_growth_factor expression by adenosine through adenosine A2 receptors in the rat tongue treated with endotoxin .
20797711	0	adenosine	14,23	vascular_endothelial_growth_factor	75,109	adenosine	vascular endothelial growth factor	MESH:D000241	83785(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY Activation|nmod|receptors increases|nsubj|Activation increases|dobj|END_ENTITY	Activation of adenosine A2A receptors by polydeoxyribonucleotide increases vascular_endothelial_growth_factor and protects against testicular_damage induced by experimental varicocele in rats .
24136993	0	adenosine	16,25	vascular_endothelial_growth_factor	48,82	adenosine	vascular endothelial growth factor	MESH:D000241	22339(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY production|compound|END_ENTITY	Role of JunB in adenosine A2B receptor-mediated vascular_endothelial_growth_factor production .
8641834	0	adenosine	94,103	vascular_endothelial_growth_factor	18,52	adenosine	vascular endothelial growth factor	MESH:D000241	281572(Tax:9913)	Chemical	Gene	receptors|amod|START_ENTITY KDR/Flk|nmod|receptors KDR/Flk|nsubj|receptor receptor|compound|END_ENTITY	Hypoxia regulates vascular_endothelial_growth_factor receptor KDR/Flk gene expression through adenosine A2 receptors in retinal capillary endothelial cells .
9272379	0	adenosine	8,17	vascular_endothelial_growth_factor	46,80	adenosine	vascular endothelial growth factor	MESH:D000241	7422	Chemical	Gene	START_ENTITY|nmod|induction induction|nmod|END_ENTITY	Role of adenosine in the hypoxic induction of vascular_endothelial_growth_factor in porcine brain derived microvascular endothelial cells .
11543678	0	adenosine_bisphosphate	37,59	P2Y1	79,83	adenosine bisphosphate	P2Y1	CHEBI:22251	100303708(Tax:9103)	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|nmod|receptor receptor|compound|END_ENTITY	Acyclic and cyclopropyl analogues of adenosine_bisphosphate antagonists of the P2Y1 receptor : structure-activity relationships and receptor docking .
18495218	0	adenosine_diphosphate	12,33	P2Y12	6,11	adenosine diphosphate	P2Y12	MESH:D000244	64805	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|compound|END_ENTITY	Novel P2Y12 adenosine_diphosphate receptor antagonists for inhibition of platelet_aggregation -LRB- I -RRB- : in vitro effects on platelets .
20846600	0	adenosine_diphosphate	9,30	P2Y12	40,45	adenosine diphosphate	P2Y12	MESH:D000244	64805	Chemical	Gene	blockade|amod|START_ENTITY blockade|compound|END_ENTITY	Level of adenosine_diphosphate receptor P2Y12 blockade during percutaneous coronary intervention predicts the extent of endothelial injury , assessed by circulating endothelial cell measurement .
21497813	0	adenosine_diphosphate	105,126	P2Y12	99,104	adenosine diphosphate	P2Y12	MESH:D000244	64805	Chemical	Gene	reactivity|compound|START_ENTITY reactivity|compound|END_ENTITY	The P-selectin gene Pro715 allele and low levels of soluble P-selectin are associated with reduced P2Y12 adenosine_diphosphate receptor reactivity in clopidogrel-treated patients .
26588064	0	adenosine_diphosphate	88,109	P2Y12	82,87	adenosine diphosphate	P2Y12	MESH:D000244	64805	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	New highly active antiplatelet agents with dual specificity for platelet P2Y1 and P2Y12 adenosine_diphosphate receptors .
24033727	0	adenosine_monophosphate	35,58	AMPD	70,74	adenosine monophosphate	AMPD	MESH:D000249	270	Chemical	Gene	deficiency|amod|START_ENTITY deficiency|appos|END_ENTITY	Hypersomnia with dilated pupils in adenosine_monophosphate deaminase -LRB- AMPD -RRB- deficiency .
24617546	0	adenosine_monophosphate	16,39	AMPK	58,62	adenosine monophosphate	AMPK	MESH:D000249	5563	Chemical	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	Perspectives of adenosine_monophosphate activated kinase -LRB- AMPK -RRB- signalling pathway in thyroid_cancer .
4293828	0	adenosine_tetraphosphate	16,40	myosin	46,52	adenosine tetraphosphate	myosin	CHEBI:18334	79784	Chemical	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of adenosine_tetraphosphate with myosin and actomyosin .
26506716	0	adenosine_triphosphate	36,58	BK_channel	62,72	adenosine triphosphate	BK channel	MESH:D000255	83731(Tax:10116)	Chemical	Gene	mechanism|nmod|START_ENTITY mechanism|nmod|END_ENTITY	-LSB- Effects and activated mechanism of adenosine_triphosphate on BK_channel of coronary smooth muscle cells -RSB- .
24187567	0	adenosine_triphosphate	126,148	CD4	121,124	adenosine triphosphate	CD4	MESH:D000255	920	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Immunological aspects in late phase of living donor liver transplant patients : usefulness of monitoring peripheral blood CD4 + adenosine_triphosphate activity .
11795466	0	adenosine_triphosphate	15,37	Hsp90	56,61	adenosine triphosphate	Hsp90	MESH:D000255	3320	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	The N-terminal adenosine_triphosphate binding domain of Hsp90 is necessary and sufficient for interaction with estrogen_receptor .
12424458	0	adenosine_triphosphate	14,36	P2X3	37,41	adenosine triphosphate	P2X3	MESH:D000255	81739(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	Expression of adenosine_triphosphate P2X3 receptors in rat molar pulp and trigeminal ganglia .
8522598	0	adenosine_triphosphate	19,41	Sac1p	0,5	adenosine triphosphate	Sac1p	MESH:D000255	853668(Tax:4932)	Chemical	Gene	transport|amod|START_ENTITY mediates|dobj|transport mediates|nsubj|END_ENTITY	Sac1p mediates the adenosine_triphosphate transport into yeast endoplasmic reticulum that is required for protein translocation .
4091009	0	adenosine_triphosphate	36,58	VIP	114,117	adenosine triphosphate	VIP	MESH:D000255	7432	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of intra-arterially infused adenosine_triphosphate -LRB- ATP -RRB- on release of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- from the gastrointestinal tract of the cat .
17330863	0	adenosine_triphosphate	14,36	glutamate_transporter-1	45,68	adenosine triphosphate	glutamate transporter-1	MESH:D000255	29482(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Extracellular adenosine_triphosphate induces glutamate_transporter-1 expression in hippocampus .
10398298	0	adenosine_triphosphate	14,36	neural_cell_adhesion_molecule	45,74	adenosine triphosphate	neural cell adhesion molecule	MESH:D000255	24586(Tax:10116)	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|END_ENTITY	Extracellular adenosine_triphosphate affects neural_cell_adhesion_molecule -LRB- NCAM -RRB- - mediated cell adhesion and neurite outgrowth .
7529026	0	adenosine_triphosphate	139,161	porin	25,30	adenosine triphosphate	porin	MESH:D000255	7416	Chemical	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Channel active mammalian porin , purified from crude membrane fractions of human B lymphocytes and bovine skeletal muscle , reversibly binds adenosine_triphosphate -LRB- ATP -RRB- .
836885	0	adenosine_triphosphate	54,76	progesterone_receptor	15,36	adenosine triphosphate	progesterone receptor	MESH:D000255	5241	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of progesterone_receptor with immobilized adenosine_triphosphate .
20450932	0	adenosine_triphosphate	62,84	transglutaminase_2	27,45	adenosine triphosphate	transglutaminase 2	MESH:D000255	7052	Chemical	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Crystal structure of human transglutaminase_2 in complex with adenosine_triphosphate .
15918975	0	adenosine_triphosphate	75,97	uncoupling_protein_2	15,35	adenosine triphosphate	uncoupling protein 2	MESH:D000255	54315(Tax:10116)	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of uncoupling_protein_2 and its relationship to the content of adenosine_triphosphate in the nonalcoholic fatty livers of rats fed a high-fat diet -RSB- .
4091009	0	adenosine_triphosphate	36,58	vasoactive_intestinal_polypeptide	79,112	adenosine triphosphate	vasoactive intestinal polypeptide	MESH:D000255	7432	Chemical	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	Effects of intra-arterially infused adenosine_triphosphate -LRB- ATP -RRB- on release of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- from the gastrointestinal tract of the cat .
10725253	0	adenosine_triphosphates	76,99	P2Y	4,7	adenosine triphosphates	P2Y	null	25265(Tax:10116)	Chemical	Gene	receptor|nmod|START_ENTITY receptor|compound|END_ENTITY	The P2Y -LRB- 1 -RRB- receptor closes the N-type Ca -LRB- 2 + -RRB- channel in neurones , with both adenosine_triphosphates and diphosphates as potent agonists .
9855642	0	adenosine_triphosphates	18,41	P2Y1_receptor	55,68	adenosine triphosphates	P2Y1 receptor	null	5028	Chemical	Gene	action|nmod|START_ENTITY action|nmod|END_ENTITY	Agonist action of adenosine_triphosphates at the human P2Y1_receptor .
6696751	0	adenosylmethionine	58,76	betaine-homocysteine_methyltransferase	16,54	adenosylmethionine	betaine-homocysteine methyltransferase	null	81508(Tax:10116)	Chemical	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of betaine-homocysteine_methyltransferase by adenosylmethionine and adenosylethionine .
3818603	0	adenosylmethionine	64,82	methylenetetrahydrofolate_reductase	25,60	adenosylmethionine	methylenetetrahydrofolate reductase	null	4524	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Allosteric inhibition of methylenetetrahydrofolate_reductase by adenosylmethionine .
2850389	0	adenylate	82,91	AK2	100,103	adenylate	AK2	CHEBI:16027	204	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	Effect of reduction and carboxamidomethylation on immunogenicity of mitochondrial adenylate kinase -LRB- AK2 -RRB- .
3002789	0	adenylate	14,23	AK2	32,35	adenylate	AK2	CHEBI:16027	280716(Tax:9913)	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	Mitochondrial adenylate kinase -LRB- AK2 -RRB- from bovine heart .
3019476	0	adenylate	64,73	Corticotropin_releasing_factor	0,30	adenylate	Corticotropin releasing factor	CHEBI:16027	81648(Tax:10116)	Chemical	Gene	stimulation|nmod|START_ENTITY stimulation|amod|END_ENTITY	Corticotropin_releasing_factor receptor-mediated stimulation of adenylate cyclase activity in the rat brain .
6139729	0	adenylate	43,52	Growth_hormone-releasing_factor	0,31	adenylate	Growth hormone-releasing factor	CHEBI:16027	2691	Chemical	Gene	START_ENTITY|nsubj|stimulates stimulates|compound|END_ENTITY	Growth_hormone-releasing_factor stimulates adenylate cyclase activity in the anterior pituitary gland .
6320659	0	adenylate	60,69	PTH	10,13	adenylate	PTH	CHEBI:16027	24694(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of PTH and 1,25 -LRB- OH -RRB- 2D3 on renal 25 -LRB- OH -RRB- D3 metabolism , adenylate cyclase , and protein_kinase .
217627	0	adenylate	35,44	Parathyroid_hormone	0,19	adenylate	Parathyroid hormone	CHEBI:16027	24694(Tax:10116)	Chemical	Gene	stimulation|nmod|START_ENTITY stimulation|amod|END_ENTITY	Parathyroid_hormone stimulation of adenylate cyclase activity and lactic_acid accumulation in calvaria of osteopetrotic -LRB- ia -RRB- rats .
6258654	0	adenylate	53,62	Parathyroid_hormone	0,19	adenylate	Parathyroid hormone	CHEBI:16027	24694(Tax:10116)	Chemical	Gene	stimulation|nmod|START_ENTITY stimulation|amod|END_ENTITY	Parathyroid_hormone and isoproterenol stimulation of adenylate cyclase in rat_osteosarcoma clonal cells .
17349953	0	adenylate	6,15	Rad50	0,5	adenylate	Rad50	CHEBI:16027	855471(Tax:4932)	Chemical	Gene	activity|amod|START_ENTITY activity|nummod|END_ENTITY	Rad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes .
1346787	0	adenylate	38,47	Somatostatin	0,12	adenylate	Somatostatin	CHEBI:16027	6750	Chemical	Gene	cyclase|amod|START_ENTITY activity|nmod|cyclase inhibits|dobj|activity inhibits|nsubj|END_ENTITY	Somatostatin inhibits the activity of adenylate cyclase in cultured human meningioma cells and stimulates their growth .
2568880	0	adenylate	27,36	Somatostatin	0,12	adenylate	Somatostatin	CHEBI:16027	6750	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Somatostatin inhibition of adenylate cyclase activity in different brain areas .
19912854	0	adenylate	71,80	angiotensin_II	41,55	adenylate	angiotensin II	CHEBI:16027	24179(Tax:10116)	Chemical	Gene	receptors|nmod|START_ENTITY receptors|amod|END_ENTITY	PKC modulation of inhibitory coupling of angiotensin_II receptors with adenylate cyclase in lactotroph cells .
2139162	0	adenylate	44,53	atrial_natriuretic_peptide	10,36	adenylate	atrial natriuretic peptide	CHEBI:16027	24602(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY Effect|nmod|activity Effect|nmod|END_ENTITY	Effect of atrial_natriuretic_peptide on the adenylate cyclase activity in the anterior and neurointermediate pituitary lobes of rats .
15684079	0	adenylate	105,114	cystic_fibrosis_transmembrane_conductance_regulator	45,96	adenylate	cystic fibrosis transmembrane conductance regulator	CHEBI:16027	1080	Chemical	Gene	activity|amod|START_ENTITY END_ENTITY|nmod|activity	ADP inhibits function of the ABC transporter cystic_fibrosis_transmembrane_conductance_regulator via its adenylate kinase activity .
22038794	0	adenylate	40,49	hCINAP	0,6	adenylate	hCINAP	CHEBI:16027	102157402	Chemical	Gene	kinase|compound|START_ENTITY kinase|nsubj|END_ENTITY	hCINAP is an atypical mammalian nuclear adenylate kinase with an ATPase motif : structural and functional studies .
228775	1	adenylate	84,93	myosin	124,130	adenylate	myosin	CHEBI:16027	79784	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Detection of adenylate kinase activity in a purified myosin subfragment I -RSB- .
7649305	0	adenylyl	65,73	ANP-C	116,121	adenylyl	ANP-C	null	4883	Chemical	Gene	activity|amod|START_ENTITY activity|dep|END_ENTITY	C-type_natriuretic_peptide and brain_natriuretic_peptide inhibit adenylyl cyclase activity : interaction with ANF-R2 / ANP-C receptors .
7798937	0	adenylyl	57,65	corticotropin-releasing_hormone	12,43	adenylyl	corticotropin-releasing hormone	null	1392	Chemical	Gene	receptors|nmod|START_ENTITY receptors|amod|END_ENTITY	Coupling of corticotropin-releasing_hormone receptors to adenylyl cyclase in human Y-79 retinoblastoma cells .
9537680	0	adenylyl	123,131	protein_kinase_A	82,98	adenylyl	protein kinase A	null	25636(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Repeated methylphenidate treatment induces behavioral sensitization and decreases protein_kinase_A and dopamine-stimulated adenylyl cyclase activity in the dorsal striatum .
6698384	0	adrenaline	14,24	A1AT	74,78	adrenaline	A1AT	MESH:D004837	5265	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of adrenaline , acetylcholine and histamine on aminotransferase A1AT and AspAT and cholinesterase activity in blood plasma of 1 to 3-day-old chicks .
8817361	0	adrenaline	34,44	Insulin	0,7	adrenaline	Insulin	MESH:D004837	3630	Chemical	Gene	START_ENTITY|nsubj|responses responses|compound|END_ENTITY	Insulin and glucagon responses to adrenaline infusion in abdominal obese men .
12111350	0	adrenaline	10,20	PDE4	86,90	adrenaline	PDE4	MESH:D004837	5141	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of adrenaline and glucocorticoids on monocyte cAMP-specific phosphodiesterase -LRB- PDE4 -RRB- in a monocytic cell line .
6818113	0	adrenaline	134,144	VIII	92,96	adrenaline	VIII	MESH:D004837	1351	Chemical	Gene	infusion|nmod|START_ENTITY END_ENTITY|nmod|infusion	The potentiating effect of cortisone -LRB- prednisolone -RRB- on the fibrinolytic and clotting factor VIII responses to intravenous infusion of adrenaline in man .
2978742	0	adrenaline	42,52	atrial_natriuretic_peptide	12,38	adrenaline	atrial natriuretic peptide	MESH:D004837	4878	Chemical	Gene	Response|acl|START_ENTITY Response|nmod|END_ENTITY	Response of atrial_natriuretic_peptide to adrenaline and noradrenaline infusion in man .
184685	0	adrenaline	10,20	cyclic_AMP	39,49	adrenaline	cyclic AMP	MESH:D004837	316010(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|release release|nmod|END_ENTITY	Effect of adrenaline on the release of cyclic_AMP by the rat diaphragm .
10333490	0	adrenaline	61,71	hormone-sensitive_lipase	14,38	adrenaline	hormone-sensitive lipase	MESH:D004837	3991	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of hormone-sensitive_lipase and its regulation by adrenaline in skeletal muscle .
12713515	0	adrenaline	14,24	hormone-sensitive_lipase	45,69	adrenaline	hormone-sensitive lipase	MESH:D004837	25330(Tax:10116)	Chemical	Gene	Additivity|nmod|START_ENTITY Additivity|nmod|END_ENTITY	Additivity of adrenaline and contractions on hormone-sensitive_lipase , but not on glycogen phosphorylase , in rat muscle .
10844399	0	adrenaline	11,21	insulin	41,48	adrenaline	insulin	MESH:D004837	3630	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of adrenaline and tolbutamide on insulin secretion in INS-1 cells under voltage control .
1765054	0	adrenaline	22,32	insulin	51,58	adrenaline	insulin	MESH:D004837	3630	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|interaction interaction|nmod|END_ENTITY	Thermogenic effect of adrenaline : interaction with insulin .
2440143	0	adrenaline	74,84	insulin	18,25	adrenaline	insulin	MESH:D004837	3630	Chemical	Gene	levels|amod|START_ENTITY infusions|nmod|levels infusions|nsubj|Effects Effects|nmod|END_ENTITY	Effects of graded insulin infusions on plasma levels of free fatty_acids , adrenaline and noradrenaline directly after open heart surgery .
3002669	0	adrenaline	72,82	insulin	52,59	adrenaline	insulin	MESH:D004837	3630	Chemical	Gene	facilitates|nmod|START_ENTITY facilitates|dobj|response response|compound|END_ENTITY	Selective alpha 2 receptor blockade facilitates the insulin response to adrenaline but not to glucose in man .
3002669	7	adrenaline	1153,1163	insulin	1167,1174	adrenaline	insulin	MESH:D004837	3630	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	Therefore the effect of adrenaline on insulin release is mediated by way of inhibitory alpha 2 adrenoceptors in the pancreas , while the release of insulin in response to glucose in a resting subject is independent of the alpha-adrenergic system .
6341134	0	adrenaline	35,45	insulin	67,74	adrenaline	insulin	MESH:D004837	483665(Tax:9615)	Chemical	Gene	effects|nmod|START_ENTITY Differences|nmod|effects Differences|nmod|secretion secretion|compound|END_ENTITY	Differences between the effects of adrenaline and noradrenaline on insulin secretion in the dog .
7000956	0	adrenaline	11,21	insulin	56,63	adrenaline	insulin	MESH:D004837	105613195	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|release release|nmod|END_ENTITY	Effects of adrenaline and amino_acids on the release of insulin in the sheep fetus .
8277227	0	adrenaline	35,45	insulin	64,71	adrenaline	insulin	MESH:D004837	3630	Chemical	Gene	START_ENTITY|nmod|profile profile|nmod|END_ENTITY	Concentration-dependent effects of adrenaline on the profile of insulin secretion from isolated human islets of Langerhans .
19053318	0	adrenaline	118,128	multidrug_resistance_protein_1	70,100	adrenaline	multidrug resistance protein 1	MESH:D004837	24565(Tax:10116)	Chemical	Gene	uptake|nmod|START_ENTITY END_ENTITY|nmod|uptake	Cross-functioning between the extraneuronal monoamine transporter and multidrug_resistance_protein_1 in the uptake of adrenaline and export of 5 - -LRB- glutathion-S-yl -RRB- adrenaline in rat cardiomyocytes .
18647601	0	adrenaline	52,62	neuromedin_U	23,35	adrenaline	neuromedin U	MESH:D004837	63887(Tax:10116)	Chemical	Gene	elevates|dobj|START_ENTITY elevates|nsubj|END_ENTITY	Centrally administered neuromedin_U elevates plasma adrenaline by brain prostanoid TP receptor-mediated mechanisms in rats .
6145423	0	adrenaline	147,157	phenylethanolamine-N-methyltransferase	84,122	adrenaline	phenylethanolamine-N-methyltransferase	MESH:D004837	5409	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Changes in tyrosine hydroxylase and dopamine-beta-hydroxylase activities but not in phenylethanolamine-N-methyltransferase activity within central adrenaline neurons after 6-hydroxydopamine administration .
1813878	0	adrenaline	18,28	renin	55,60	adrenaline	renin	MESH:D004837	5972	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	-LSB- Plasma levels of adrenaline and noradrenaline , plasma renin activity and arterial blood pressure in patients after kidney transplantation -RSB- .
6102803	0	adrenaline	48,58	somatostatin	11,23	adrenaline	somatostatin	MESH:D004837	24797(Tax:10116)	Chemical	Gene	epinephrine|appos|START_ENTITY inhibit|dobj|epinephrine Failure|acl|inhibit Failure|nmod|END_ENTITY	Failure of somatostatin to inhibit epinephrine -LRB- adrenaline -RRB- - stimulated hepatic_glucose_output in vitro .
6120054	0	adrenaline	89,99	somatostatin	13,25	adrenaline	somatostatin	MESH:D004837	6750	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of somatostatin on plasma cyclic_AMP and metabolic substrate responses to i.v. adrenaline and glucagon in humans .
2046301	0	adrenaline	15,25	succinate_dehydrogenase	33,56	adrenaline	succinate dehydrogenase	MESH:D004837	30956(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY -LSB-|dobj|effect -LSB-|nmod|activity activity|amod|END_ENTITY	-LSB- The effect of adrenaline on the succinate_dehydrogenase activity in functionally changed -LRB- lymphoid leukosis -RRB- lymphocytes in mice -RSB- .
1329800	0	adrenocorticotropin	51,70	ACTH	72,76	adrenocorticotropin	ACTH	MESH:D000324	5443	Chemical	Gene	secretion|amod|START_ENTITY secretion|appos|END_ENTITY	Buprenorphine attenuates the effects of cocaine on adrenocorticotropin -LRB- ACTH -RRB- secretion and mood states in man .
6284783	0	adrenocorticotropin	12,31	ACTH	33,37	adrenocorticotropin	ACTH	MESH:D000324	5443	Chemical	Gene	secretion|amod|START_ENTITY secretion|appos|END_ENTITY	Dynamics of adrenocorticotropin -LRB- ACTH -RRB- secretion in cyclic Cushing 's _ syndrome : evidence for more than one abnormal ACTH biorhythm .
3007553	0	adrenocorticotropin	67,86	Beta-endorphin	0,14	adrenocorticotropin	Beta-endorphin	MESH:D000324	5443	Chemical	Gene	attenuates|nmod|START_ENTITY attenuates|nsubj|END_ENTITY	Beta-endorphin attenuates the serum cortisol response to exogenous adrenocorticotropin .
9357057	0	adrenocorticotropin	23,42	Bombesin	0,8	adrenocorticotropin	Bombesin	MESH:D000324	2922	Chemical	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	Bombesin regulation of adrenocorticotropin release from ovine anterior pituitary cells .
20546949	1	adrenocorticotropin	166,185	CRH	238,241	adrenocorticotropin	CRH	MESH:D000324	81648(Tax:10116)	Chemical	Gene	hormone|compound|START_ENTITY hormone|appos|END_ENTITY	We attempted to determine whether acute treatment with adrenocorticotropin hormone -LRB- ACTH -RRB- and corticotropin_releasing_hormone -LRB- CRH -RRB- affects mitochondrial morphology , as evaluated by the HRSEM and osmium maceration methods .
2988916	0	adrenocorticotropin	46,65	Corticotropin-releasing_factor	0,30	adrenocorticotropin	Corticotropin-releasing factor	MESH:D000324	81648(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY stimulation|nmod|release stimulation|amod|END_ENTITY	Corticotropin-releasing_factor stimulation of adrenocorticotropin and beta-endorphin release : effects of acute and chronic stress .
1649838	0	adrenocorticotropin	82,101	Corticotropin-releasing_hormone	0,31	adrenocorticotropin	Corticotropin-releasing hormone	MESH:D000324	1392	Chemical	Gene	release|compound|START_ENTITY mediating|dobj|release factor|acl|mediating factor|nsubj|END_ENTITY	Corticotropin-releasing_hormone is not the sole factor mediating exercise-induced adrenocorticotropin release in humans .
3007552	0	adrenocorticotropin	84,103	Corticotropin-releasing_hormone	0,31	adrenocorticotropin	Corticotropin-releasing hormone	MESH:D000324	1392	Chemical	Gene	secretion|compound|START_ENTITY response|nmod|secretion stimulation|dep|response stimulation|amod|END_ENTITY	Corticotropin-releasing_hormone -LRB- CRH -RRB- stimulation in Nelson 's _ syndrome : response of adrenocorticotropin secretion to pulse injection and continuous infusion of CRH .
8114760	0	adrenocorticotropin	37,56	FOS	13,16	adrenocorticotropin	FOS	MESH:D000324	14281(Tax:10090)	Chemical	Gene	proteins|nmod|START_ENTITY proteins|compound|END_ENTITY	Induction of FOS and JUN proteins by adrenocorticotropin and phorbol_ester but not by 3 ' ,5 ' - cyclic_adenosine_monophosphate derivatives .
6311519	0	adrenocorticotropin	31,50	angiotensin_II	11,25	adrenocorticotropin	angiotensin II	MESH:D000324	24179(Tax:10116)	Chemical	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of angiotensin_II , K + , adrenocorticotropin , serotonin , adenosine 3 ' ,5 ' - monophosphate , guanosine 3 ' ,5 ' - monophosphate , A23187 , and EGTA on aldosterone synthesis and phospholipid metabolism in the rat adrenal zona glomerulosa .
1311050	0	adrenocorticotropin	28,47	corticotropin-releasing_hormone	77,108	adrenocorticotropin	corticotropin-releasing hormone	MESH:D000324	81648(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY enhances|dobj|concentration enhances|advcl|stimulating stimulating|dobj|secretion secretion|amod|END_ENTITY	Neurotensin enhances plasma adrenocorticotropin concentration by stimulating corticotropin-releasing_hormone secretion .
1851183	0	adrenocorticotropin	86,105	corticotropin-releasing_hormone	51,82	adrenocorticotropin	corticotropin-releasing hormone	MESH:D000324	1392	Chemical	Gene	cortisol|compound|START_ENTITY pulsatile|nmod|cortisol pulsatile|dobj|END_ENTITY	Dose-response effects of exogenous pulsatile human corticotropin-releasing_hormone on adrenocorticotropin , cortisol , and gonadotropin concentrations in agonadal women .
2172283	0	adrenocorticotropin	115,134	corticotropin-releasing_hormone	40,71	adrenocorticotropin	corticotropin-releasing hormone	MESH:D000324	1392	Chemical	Gene	combined|nmod|START_ENTITY combined|nsubj|Effects Effects|nmod|administration administration|nmod|END_ENTITY	Effects of repetitive administration of corticotropin-releasing_hormone combined with lysine_vasopressin on plasma adrenocorticotropin and cortisol levels in secondary adrenocortical_insufficiency .
2538990	0	adrenocorticotropin	88,107	corticotropin-releasing_hormone	140,171	adrenocorticotropin	corticotropin-releasing hormone	MESH:D000324	1392	Chemical	Gene	comparison|nmod|START_ENTITY comparison|nmod|END_ENTITY	The corticotropin-releasing_hormone test in normal short children : comparison of plasma adrenocorticotropin and cortisol responses to human corticotropin-releasing_hormone and insulin-induced hypoglycemia .
2538990	0	adrenocorticotropin	88,107	corticotropin-releasing_hormone	4,35	adrenocorticotropin	corticotropin-releasing hormone	MESH:D000324	1392	Chemical	Gene	comparison|nmod|START_ENTITY test|dep|comparison test|amod|END_ENTITY	The corticotropin-releasing_hormone test in normal short children : comparison of plasma adrenocorticotropin and cortisol responses to human corticotropin-releasing_hormone and insulin-induced hypoglycemia .
2831247	0	adrenocorticotropin	62,81	corticotropin-releasing_hormone	9,40	adrenocorticotropin	corticotropin-releasing hormone	MESH:D000324	1392	Chemical	Gene	release|compound|START_ENTITY stimulation|nmod|release stimulation|amod|END_ENTITY	In vitro corticotropin-releasing_hormone -LRB- CRH -RRB- stimulation of adrenocorticotropin release from corticotroph_adenoma cells : effect of prolonged exposure to CRH and its interaction with cortisol .
2855105	0	adrenocorticotropin	55,74	corticotropin-releasing_hormone	88,119	adrenocorticotropin	corticotropin-releasing hormone	MESH:D000324	1392	Chemical	Gene	responses|compound|START_ENTITY modifies|dobj|responses modifies|nmod|END_ENTITY	Loperamide , an opiate analog , differently modifies the adrenocorticotropin responses to corticotropin-releasing_hormone and lysine_vasopressin in patients with Addison 's _ disease .
3033009	0	adrenocorticotropin	107,126	corticotropin-releasing_hormone	16,47	adrenocorticotropin	corticotropin-releasing hormone	MESH:D000324	1392	Chemical	Gene	hypoglycemia|nmod|START_ENTITY administered|nmod|hypoglycemia administered|nsubj|Effect Effect|nmod|END_ENTITY	Effect of ovine corticotropin-releasing_hormone administered during insulin-induced hypoglycemia on plasma adrenocorticotropin and cortisol .
9430449	0	adrenocorticotropin	134,153	corticotropin-releasing_hormone	83,114	adrenocorticotropin	corticotropin-releasing hormone	MESH:D000324	1392	Chemical	Gene	secretion|compound|START_ENTITY shows|nmod|secretion shows|dobj|interaction interaction|nmod|END_ENTITY	Hexarelin , a synthetic growth-hormone releasing peptide , shows no interaction with corticotropin-releasing_hormone and vasopressin on adrenocorticotropin and cortisol secretion in humans .
10814737	0	adrenocorticotropin	104,123	leukemia_inhibitory_factor	22,48	adrenocorticotropin	leukemia inhibitory factor	MESH:D000324	60584(Tax:10116)	Chemical	Gene	secretion|compound|START_ENTITY role|nmod|secretion role|nmod|END_ENTITY	A significant role of leukemia_inhibitory_factor in the brain and periphery in endotoxin stimulation of adrenocorticotropin secretion in the rat .
6302146	0	adrenocorticotropin	13,32	milk	38,42	adrenocorticotropin	milk	MESH:D000324	100532204	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|production production|compound|END_ENTITY	Influence of adrenocorticotropin upon milk production , milk constituents , and endocrine measures of dairy cows .
14701678	0	adrenocorticotropin	22,41	p90	92,95	adrenocorticotropin	p90	MESH:D000324	7037	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Identification of the adrenocorticotropin and ginkgolide_B-regulated 90-kilodalton protein -LRB- p90 -RRB- in adrenocortical cells as a serotransferrin precursor protein homolog -LRB- adrenotransferrin -RRB- .
2859983	0	adrenocorticotropin	50,69	somatostatin	23,35	adrenocorticotropin	somatostatin	MESH:D000324	20604(Tax:10090)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Multiple mechanisms of somatostatin inhibition of adrenocorticotropin release from mouse anterior pituitary_tumor cells .
21568777	0	adrenocorticotropin	138,157	thyrotropin-releasing_hormone	88,117	adrenocorticotropin	thyrotropin-releasing hormone	MESH:D000324	100056248(Tax:9796)	Chemical	Gene	concentration|compound|START_ENTITY END_ENTITY|nmod|concentration	a-Melanocyte -- stimulating hormone and adrenocorticotropin concentrations in response to thyrotropin-releasing_hormone and comparison with adrenocorticotropin concentration after domperidone administration in healthy horses and horses with pituitary_pars_intermedia_dysfunction .
6321557	0	adrenocorticotropin	33,52	vasopressin	9,20	adrenocorticotropin	vasopressin	MESH:D000324	551	Chemical	Gene	release|compound|START_ENTITY potentiates|dobj|release potentiates|nsubj|END_ENTITY	Arginine vasopressin potentiates adrenocorticotropin release induced by ovine corticotropin-releasing factor .
14742915	0	adrenomedullin	20,34	CGRP	71,75	adrenomedullin	CGRP	MESH:D053607	796	Chemical	Gene	receptors|compound|START_ENTITY pharmacology|nmod|receptors pharmacology|nmod|receptors receptors|compound|END_ENTITY	The pharmacology of adrenomedullin receptors and their relationship to CGRP receptors .
16702994	0	adrenomedullin	53,67	CGRP	105,109	adrenomedullin	CGRP	MESH:D053607	24241(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Characterization and effects on cAMP accumulation of adrenomedullin and calcitonin_gene-related_peptide -LRB- CGRP -RRB- receptors in dissociated rat spinal cord cell culture .
8898020	0	adrenomedullin	10,24	CGRP	79,83	adrenomedullin	CGRP	MESH:D053607	24241(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|comparison comparison|nmod|END_ENTITY	Effect of adrenomedullin on cAMP levels along the rat nephron : comparison with CGRP .
9931292	1	adrenomedullin	278,292	CGRP	399,403	adrenomedullin	CGRP	MESH:D053607	24241(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|absence absence|nmod|calcitonin-gene-related_peptide calcitonin-gene-related_peptide|appos|END_ENTITY	Rat-2 fibroblasts demonstrate specific binding of 125I-labelled rat adrenomedullin -LRB- KD = 0.43 nM ; Bmax = 50 fmol/mg of protein -RRB- in the absence of 125I-labelled calcitonin-gene-related_peptide -LRB- CGRP -RRB- binding .
11841788	0	adrenomedullin	21,35	endothelin-1	89,101	adrenomedullin	endothelin-1	MESH:D053607	281137(Tax:9913)	Chemical	Gene	synthesis|amod|START_ENTITY synthesis|amod|END_ENTITY	Inhibitory effect of adrenomedullin on basal and tumour necrosis factor alpha-stimulated endothelin-1 synthesis in bovine aortic endothelial cells is independent of cyclic_AMP .
11775262	0	adrenotensin	22,34	adrenomedullin	61,75	adrenotensin	adrenomedullin	MESH:C094997	25026(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Vasoactive effects of adrenotensin and its interactions with adrenomedullin .
19597528	0	adrenotensin	10,22	angiotensin_II	60,74	adrenotensin	angiotensin II	MESH:C094997	24179(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY mediated|nsubjpass|Effect mediated|nmod|END_ENTITY	Effect of adrenotensin on cell proliferation is mediated by angiotensin_II in cultured rat mesangial cells .
25337234	0	adriamycin	10,20	BRCA1	24,29	adriamycin	BRCA1	MESH:D004317	672	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of adriamycin on BRCA1 and PARP-1 expression in MCF-7 breast_cancer cells .
15389553	0	adriamycin	52,62	Bsd2	17,21	adriamycin	Bsd2	MESH:D004317	852593(Tax:4932)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A novel role for Bsd2 in the resistance of yeast to adriamycin .
11162602	3	adriamycin	506,516	G2_arrest	486,495	adriamycin	cyclin B1	MESH:D004317	891	Chemical	Gene	treatment|compound|START_ENTITY END_ENTITY|nmod|treatment	In this manner , we identified several up - or down-regulated genes in cells undergoing G2_arrest following adriamycin treatment ; among them , cyclin_B1 expression was dramatically reduced .
17493331	0	adriamycin	11,21	Gfi-1	25,30	adriamycin	Gfi-1	MESH:D004317	2672	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	-LSB- Effect of adriamycin on Gfi-1 expression in K562 cells and its relationship with the relevant apoptotic genes -RSB- .
17493331	1	adriamycin	161,171	Gfi-1	282,287	adriamycin	Gfi-1	MESH:D004317	2672	Chemical	Gene	effect|nmod|START_ENTITY explore|dobj|effect explore|nmod|cells cells|nmod|END_ENTITY	The study was purposed to explore the effect of adriamycin -LRB- ADM -RRB- on K562 cells in vitro and the mechanism of expression changes of relevant apoptotic genes and oncogene Gfi-1 .
3497116	0	adriamycin	11,21	IL-2	105,109	adriamycin	IL-2	MESH:D004317	116562(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|release release|nmod|END_ENTITY	Effects of adriamycin , 4-hydroperoxycyclophosphamide and ASTA Z 7557 -LRB- INN_mafosfamide -RRB- on the release of IL-2 and IL-1 in vitro .
22282250	0	adriamycin	24,34	MMP-2	15,20	adriamycin	MMP-2	MESH:D004317	4313	Chemical	Gene	resistance|compound|START_ENTITY END_ENTITY|nmod|resistance	Involvement of MMP-2 in adriamycin resistance dependent on ERK1/2 signal pathway in human osteosarcoma MG-63 cells .
16214181	0	adriamycin	90,100	Mad2beta	0,8	adriamycin	Mad2beta	MESH:D004317	10459	Chemical	Gene	induced|nmod|START_ENTITY induced|advmod|END_ENTITY	Mad2beta , an alternative variant of Mad2 reducing mitotic_arrest and apoptosis induced by adriamycin in gastric_cancer cells .
7923555	0	adriamycin	36,46	P-glycoprotein	109,123	adriamycin	P-glycoprotein	MESH:D004317	5243	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|END_ENTITY	Quercetin potentiates the effect of adriamycin in a multidrug-resistant MCF-7 human breast-cancer cell line : P-glycoprotein as a possible target .
18259121	0	adriamycin	82,92	RUNX3	0,5	adriamycin	RUNX3	MESH:D004317	12399(Tax:10090)	Chemical	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	RUNX3 inhibits growth of HCC cells and HCC xenografts in mice in combination with adriamycin .
1577771	0	adriamycin	26,36	Transferrin	0,11	adriamycin	Transferrin	MESH:D004317	7018	Chemical	Gene	conjugates|nmod|START_ENTITY conjugates|compound|END_ENTITY	Transferrin conjugates of adriamycin are cytotoxic without intercalating nuclear DNA .
9673350	0	adriamycin	33,43	Transferrin	0,11	adriamycin	Transferrin	MESH:D004317	7018	Chemical	Gene	delivery|nmod|START_ENTITY directed|dobj|delivery directed|nsubj|END_ENTITY	Transferrin directed delivery of adriamycin to human cells .
1012648	0	adriamycin	43,53	VP-16	14,19	adriamycin	VP-16	MESH:D004317	3054	Chemical	Gene	Evaluation|nmod|START_ENTITY Evaluation|nmod|END_ENTITY	Evaluation of VP-16 and the combination of adriamycin and vincristine in advanced breast_cancer .
6295596	1	adriamycin	79,89	VP_16	68,73	adriamycin	VP 16	MESH:D004317	3054	Chemical	Gene	comparison|nmod|START_ENTITY comparison|nmod|END_ENTITY	A comparison of VP_16 with adriamycin .
17767044	0	adriamycin	60,70	cardiotrophin-1	15,30	adriamycin	cardiotrophin-1	MESH:D004317	29201(Tax:10116)	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of cardiotrophin-1 and effects of irbesartan in adriamycin induced cardiomyopathy in rats -RSB- .
14555538	0	adriamycin	73,83	endostatin	42,52	adriamycin	endostatin	MESH:D004317	80781	Chemical	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	Synergistic activity of recombinant human endostatin in combination with adriamycin : analysis of in vitro activity on endothelial cells and in vivo tumor progression in an orthotopic murine mammary_carcinoma model .
18615393	0	adriamycin	92,102	glutathione_peroxidase	28,50	adriamycin	glutathione peroxidase	MESH:D004317	24404(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activity activity|amod|END_ENTITY	The effects of melatonin on glutathione_peroxidase activity in serum and erythrocytes after adriamycin in normal and pinealectomised rats .
3137273	0	adriamycin	31,41	interferon-gamma	62,78	adriamycin	interferon-gamma	MESH:D004317	15978(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	Enhanced antitumor efficacy of adriamycin in combination with interferon-gamma : effects on macrophages .
2393858	0	adriamycin	66,76	interleukin-2	22,35	adriamycin	interleukin-2	MESH:D004317	16183(Tax:10090)	Chemical	Gene	efficacy|nmod|START_ENTITY efficacy|nmod|END_ENTITY	Antitumor efficacy of interleukin-2 alone and in combination with adriamycin and dacarbazine in murine solid tumor systems .
8038458	0	adriamycin	36,46	interleukin_2	52,65	adriamycin	interleukin 2	MESH:D004317	16183(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|therapy therapy|amod|END_ENTITY	Development of a safe and effective adriamycin plus interleukin_2 therapy against both adriamycin-sensitive and - resistant lymphomas .
19253827	0	adriamycin	63,73	mPer1	27,32	adriamycin	mPer1	MESH:D004317	18626(Tax:10090)	Chemical	Gene	-RSB-|compound|START_ENTITY Effects|nmod|-RSB- Effects|nmod|END_ENTITY	-LSB- Effects of circadian gene mPer1 on therapeutic sensitivity of adriamycin -RSB- .
22957792	0	adriamycin	58,68	miR-21	83,89	adriamycin	miR-21	MESH:D004317	406991	Chemical	Gene	START_ENTITY|advcl|regulating regulating|dobj|expression expression|amod|END_ENTITY	Triptolide modulates the sensitivity of K562/A02 cells to adriamycin by regulating miR-21 expression .
25623761	0	adriamycin	60,70	miR-34a	1,8	adriamycin	miR-34a	MESH:D004317	407040	Chemical	Gene	regulate|nmod|START_ENTITY regulate|nsubj|END_ENTITY	-LSB- miR-34a may regulate sensitivity of breast_cancer cells to adriamycin via targeting Notch1 -RSB- .
16540558	0	adriamycin	71,81	multidrug_resistance_protein_1	102,132	adriamycin	multidrug resistance protein 1	MESH:D004317	24565(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|upregulation upregulation|nmod|END_ENTITY	Cyclooxygenase-2 rescues rat mesangial cells from apoptosis induced by adriamycin via upregulation of multidrug_resistance_protein_1 -LRB- P-glycoprotein -RRB- .
20732145	0	adriamycin	11,21	ornithine_decarboxylase	40,63	adriamycin	ornithine decarboxylase	MESH:D004317	18263(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|amod|END_ENTITY	Effects of adriamycin and daunomycin on ornithine_decarboxylase activity and DNA synthesis in mouse epidermal cells .
18974122	0	adriamycin	80,90	p130Cas	28,35	adriamycin	p130Cas	MESH:D004317	9564	Chemical	Gene	association|nmod|START_ENTITY association|nmod|END_ENTITY	A novel association between p130Cas and resistance to the chemotherapeutic drug adriamycin in human breast_cancer cells .
17312011	0	adriamycin	87,97	p53	13,16	adriamycin	p53	MESH:D004317	22060(Tax:10090)	Chemical	Gene	treatment|compound|START_ENTITY Evidence|nmod|treatment Evidence|nmod|END_ENTITY	Evidence for p53 as guardian of the cardiomyocyte mitochondrial genome following acute adriamycin treatment .
8619835	0	adriamycin	127,137	p53	112,115	adriamycin	p53	MESH:D004317	7157	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	DNA-dependent_protein_kinase inhibitor -LRB- OK-1035 -RRB- suppresses p21 expression in HCT116 cells containing wild-type p53 induced by adriamycin .
16211306	0	adriamycin	110,120	transferrin	77,88	adriamycin	transferrin	MESH:D004317	7018	Chemical	Gene	ratio|amod|START_ENTITY effect|nmod|ratio delivery|dep|effect delivery|acl|MXT-B2 MXT-B2|nmod|liposomes liposomes|compound|END_ENTITY	Targeted adriamycin delivery to MXT-B2 metastatic mammary_carcinoma cells by transferrin liposomes : effect of adriamycin ADR-to-lipid ratio .
16211306	0	adriamycin	9,19	transferrin	77,88	adriamycin	transferrin	MESH:D004317	7018	Chemical	Gene	delivery|amod|START_ENTITY delivery|acl|MXT-B2 MXT-B2|nmod|liposomes liposomes|compound|END_ENTITY	Targeted adriamycin delivery to MXT-B2 metastatic mammary_carcinoma cells by transferrin liposomes : effect of adriamycin ADR-to-lipid ratio .
18793653	0	adriamycin	92,102	transferrin	70,81	adriamycin	transferrin	MESH:D004317	24825(Tax:10116)	Chemical	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	Melatonin controls oxidative stress and modulates iron , ferritin , and transferrin levels in adriamycin treated rats .
3566771	0	adriamycin	70,80	transferrin	9,20	adriamycin	transferrin	MESH:D004317	7018	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|reductase reductase|compound|END_ENTITY	Diferric transferrin reductase in the plasma membrane is inhibited by adriamycin .
6329566	0	adriamycin	45,55	transferrin	76,87	adriamycin	transferrin	MESH:D004317	7018	Chemical	Gene	conjugates|compound|START_ENTITY conjugates|nmod|END_ENTITY	Killing of human tumor cells in culture with adriamycin conjugates of human transferrin .
1548876	0	adriamycin	33,43	tumor_necrosis_factor-alpha	64,91	adriamycin	tumor necrosis factor-alpha	MESH:D004317	7124	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Therapeutic effects of liposomal adriamycin in combination with tumor_necrosis_factor-alpha .
2249897	0	adriamycin	92,102	tumor_necrosis_factor-alpha	106,133	adriamycin	tumor necrosis factor-alpha	MESH:D004317	21926(Tax:10090)	Chemical	Gene	accumulation|nmod|START_ENTITY Augmentation|nmod|accumulation Augmentation|nmod|END_ENTITY	Augmentation for intratumoral accumulation and anti-tumor activity of liposome-encapsulated adriamycin by tumor_necrosis_factor-alpha in mice .
17931588	0	aequorin	53,61	angiotensin_II	32,46	aequorin	angiotensin II	null	183	Chemical	Gene	using|dobj|START_ENTITY END_ENTITY|acl|using	Bioluminescence immunoassay for angiotensin_II using aequorin as a label .
24252494	0	aescin	11,17	cytochrome_P450	21,36	aescin	cytochrome P450	MESH:D004928	25251(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|enzymes enzymes|amod|END_ENTITY	Effects of aescin on cytochrome_P450 enzymes in rats .
23816960	0	afatinib	19,27	EGFR	110,114	afatinib	EGFR	MESH:C522924	1956	Chemical	Gene	plus|compound|START_ENTITY study|nmod|plus pemetrexed|nsubj|study pemetrexed|nmod|mutations mutations|amod|END_ENTITY	Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung_adenocarcinoma with EGFR mutations .
23816967	0	afatinib	72,80	EGFR	156,160	afatinib	EGFR	MESH:C522924	1956	Chemical	Gene	study|nmod|START_ENTITY study|nmod|patients patients|nmod|lung_adenocarcinoma lung_adenocarcinoma|nmod|mutations mutations|amod|END_ENTITY	Symptom control and quality of life in LUX-Lung 3 : a phase III study of afatinib or cisplatin/pemetrexed in patients with advanced lung_adenocarcinoma with EGFR mutations .
24835218	0	afatinib	202,210	EGFR	117,121	afatinib	EGFR	MESH:C522924	1956	Chemical	Gene	harboring|nmod|START_ENTITY harboring|dobj|L858R L858R|compound|END_ENTITY	Successful treatment of a patient with Li-Fraumeni_syndrome and metastatic_lung_adenocarcinoma harboring synchronous EGFR L858R and ERBB2 extracellular domain S310F mutations with the pan-HER inhibitor afatinib .
25446083	0	afatinib	28,36	EGFR	59,63	afatinib	EGFR	MESH:C522924	1956	Chemical	Gene	START_ENTITY|nmod|T790M T790M|compound|END_ENTITY	Synergistic cytotoxicity of afatinib and cetuximab against EGFR T790M involves Rab11-dependent EGFR recycling .
25446083	0	afatinib	28,36	EGFR	95,99	afatinib	EGFR	MESH:C522924	1956	Chemical	Gene	cytotoxicity|nmod|START_ENTITY involves|nsubj|cytotoxicity involves|dobj|recycling recycling|compound|END_ENTITY	Synergistic cytotoxicity of afatinib and cetuximab against EGFR T790M involves Rab11-dependent EGFR recycling .
25517450	0	afatinib	24,32	EGFR	56,60	afatinib	EGFR	MESH:C522924	1956	Chemical	Gene	Efficacy|nmod|START_ENTITY Efficacy|nmod|-RSB- -RSB-|amod|chemotherapy chemotherapy|nmod|mutation mutation|amod|END_ENTITY	-LSB- Efficacy of first-line afatinib versus chemotherapy in EGFR mutation positive pulmonary_adenocarcinoma -RSB- .
26051236	0	afatinib	21,29	EGFR	103,107	afatinib	EGFR	MESH:C522924	1956	Chemical	Gene	mutations|amod|START_ENTITY mutations|compound|END_ENTITY	Clinical activity of afatinib in patients with advanced non-small-cell_lung_cancer harbouring uncommon EGFR mutations : a combined post-hoc analysis of LUX-Lung 2 , LUX-Lung 3 , and LUX-Lung 6 .
26052929	0	afatinib	54,62	EGFR	77,81	afatinib	EGFR	MESH:C522924	1956	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Inhibition of IGF1R signaling abrogates resistance to afatinib -LRB- BIBW2992 -RRB- in EGFR T790M mutant lung_cancer cells .
26056478	0	afatinib	15,23	EGFR	108,112	afatinib	EGFR	MESH:C522924	1956	Chemical	Gene	Combination|nmod|START_ENTITY Combination|amod|resistant resistant|nmod|inhibitors inhibitors|amod|END_ENTITY	Combination of afatinib with cetuximab in patients with EGFR-mutant non-small-cell_lung_cancer resistant to EGFR inhibitors .
26418897	0	afatinib	45,53	EGFR	109,113	afatinib	EGFR	MESH:C522924	1956	Chemical	Gene	HER3|compound|START_ENTITY ligand|nsubj|HER3 ligand|nmod|inhibitors inhibitors|amod|END_ENTITY	The pan-HER family tyrosine kinase inhibitor afatinib overcomes HER3 ligand heregulin-mediated resistance to EGFR inhibitors in non-small_cell_lung_cancer .
26557768	0	afatinib	56,64	EGFR	83,87	afatinib	EGFR	MESH:C522924	1956	Chemical	Gene	therapy|nmod|START_ENTITY editor|nmod|therapy Letter|nmod|editor Letter|dep|TKI TKI|compound|END_ENTITY	Letter to the editor concerning first-line therapy with afatinib - an irreversible EGFR TKI and overall survival of NSCLC patients with EGFR gene mutations .
26782932	0	afatinib	70,78	EGFR	28,32	afatinib	EGFR	MESH:C522924	1956	Chemical	Gene	lines|nmod|START_ENTITY head_and_neck_cancer|dep|lines head_and_neck_cancer|compound|END_ENTITY	Co-treatment of wild - type EGFR head_and_neck_cancer cell lines with afatinib and cisplatin .
21970876	0	afatinib	24,32	ErbB	50,54	afatinib	ErbB	MESH:C522924	1956	Chemical	Gene	START_ENTITY|appos|blocker blocker|compound|END_ENTITY	Anti-tumour activity of afatinib , an irreversible ErbB family blocker , in human pancreatic_tumour cells .
23414476	0	afatinib	33,41	ErbB	46,50	afatinib	ErbB	MESH:C522924	1956	Chemical	Gene	START_ENTITY|appos|blocker blocker|compound|END_ENTITY	Phase I dose-escalation study of afatinib , an ErbB family blocker , plus docetaxel in patients with advanced_cancer .
23813493	0	afatinib	20,28	ErbB	55,59	afatinib	ErbB	MESH:C522924	1956	Chemical	Gene	START_ENTITY|appos|blocker blocker|compound|END_ENTITY	Pharmacokinetics of afatinib , a selective irreversible ErbB family blocker , in patients with advanced solid tumours .
24522402	0	afatinib	31,39	ErbB	57,61	afatinib	ErbB	MESH:C522924	1956	Chemical	Gene	START_ENTITY|appos|blocker blocker|compound|END_ENTITY	Population pharmacokinetics of afatinib , an irreversible ErbB family blocker , in patients with various solid_tumors .
25682316	0	afatinib	18,26	ErbB	44,48	afatinib	ErbB	MESH:C522924	1956	Chemical	Gene	START_ENTITY|appos|blocker blocker|compound|END_ENTITY	Phase II study of afatinib , an irreversible ErbB family blocker , in demographically and genotypically defined lung_adenocarcinoma .
26296295	0	afatinib	25,33	ErbB	51,55	afatinib	ErbB	MESH:C522924	1956	Chemical	Gene	START_ENTITY|appos|blocker blocker|compound|END_ENTITY	A phase I study of daily afatinib , an irreversible ErbB family blocker , in combination with weekly paclitaxel in patients with advanced solid tumours .
24378092	0	afatinib	54,62	HGF	71,74	afatinib	HGF	MESH:C522924	3082	Chemical	Gene	START_ENTITY|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Tumor microenvironment elicits primary resistance to afatinib through HGF secretion -RSB- .
12495021	0	aflatoxin	37,46	lipoxygenase	21,33	aflatoxin	lipoxygenase	MESH:D000348	547836(Tax:3847)	Chemical	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	No effect of soybean lipoxygenase on aflatoxin production in Aspergillus_flavus-inoculated seeds .
24472830	0	aflatoxin_B1	14,26	CYP1A2	50,56	aflatoxin B1	CYP1A2	MESH:D016604	1544	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Activation of aflatoxin_B1 by expression of human CYP1A2 polymorphisms in Saccharomyces_cerevisiae .
23949201	0	aflatoxin_B1	8,20	GSTM1	77,82	aflatoxin B1	GSTM1	MESH:D016604	2944	Chemical	Gene	intake|amod|START_ENTITY intake|appos|polymorphisms polymorphisms|nmod|END_ENTITY	Dietary aflatoxin_B1 intake , genetic polymorphisms of CYP1A2 , CYP2E1 , EPHX1 , GSTM1 , and GSTT1 , and gastric_cancer risk in Korean .
2549412	0	aflatoxin_B1	24,36	P-450_HFLa	40,50	aflatoxin B1	P-450 HFLa	MESH:D016604	1551	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Mutagenic activation of aflatoxin_B1 by P-450_HFLa in human fetal livers .
15170655	0	aflatoxin_B1	122,134	beta-catenin	32,44	aflatoxin B1	beta-catenin	MESH:D016604	1499	Chemical	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|END_ENTITY	Comparison of the expression of beta-catenin in hepatocellular_carcinoma in areas with high and low levels of exposure to aflatoxin_B1 .
2122459	0	aflatoxin_B1	66,78	cytochrome_P-450	46,62	aflatoxin B1	cytochrome P-450	MESH:D016604	4051	Chemical	Gene	metabolism|amod|START_ENTITY END_ENTITY|nmod|metabolism	Evidence for involvement of multiple forms of cytochrome_P-450 in aflatoxin_B1 metabolism in human liver .
3083802	0	aflatoxin_B1	21,33	cytochrome_P-450	64,80	aflatoxin B1	cytochrome P-450	MESH:D016604	25251(Tax:10116)	Chemical	Gene	activation|nmod|START_ENTITY catalysed|nsubj|activation catalysed|nmod|form form|nmod|man man|amod|END_ENTITY	Is the activation of aflatoxin_B1 catalysed by the same form of cytochrome_P-450 as that 4-hydroxylating debrisoquine in rat and/or man ?
3086716	0	aflatoxin_B1	24,36	cytochrome_P-450	66,82	aflatoxin B1	cytochrome P-450	MESH:D016604	25251(Tax:10116)	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|purified purified|nummod|END_ENTITY	Mutagenic activation of aflatoxin_B1 by several forms of purified cytochrome_P-450 .
3094515	0	aflatoxin_B1	90,102	cytochrome_P-450	47,63	aflatoxin B1	cytochrome P-450	MESH:D016604	25251(Tax:10116)	Chemical	Gene	specificity|nmod|START_ENTITY END_ENTITY|nmod|specificity	Purification and characterization of a form of cytochrome_P-450 with high specificity for aflatoxin_B1 from 3-methylcholanthrene-treated hamster liver .
3118508	0	aflatoxin_B1	38,50	cytochrome_P-450	76,92	aflatoxin B1	cytochrome P-450	MESH:D016604	25251(Tax:10116)	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|microsomes microsomes|amod|END_ENTITY	Genotoxic and mutagenic activation of aflatoxin_B1 by constitutive forms of cytochrome_P-450 in rat liver microsomes .
3132167	0	aflatoxin_B1	126,138	cytochrome_P-450	90,106	aflatoxin B1	cytochrome P-450	MESH:D016604	25251(Tax:10116)	Chemical	Gene	specific|nmod|START_ENTITY END_ENTITY|xcomp|specific	Preparation and characterization of monoclonal antibodies against a form of hamster liver cytochrome_P-450 highly specific to aflatoxin_B1 .
6436235	1	aflatoxin_B1	118,130	cytochrome_P-450	71,87	aflatoxin B1	cytochrome P-450	MESH:D016604	25251(Tax:10116)	Chemical	Gene	activation|nmod|START_ENTITY involved|nmod|activation END_ENTITY|acl|involved	Distinctive features of cytochrome_P-450 involved in the activation of aflatoxin_B1 and benzo -LRB- a -RRB- pyrene .
7732678	0	aflatoxin_B1	11,23	cytochrome_P-450	81,97	aflatoxin B1	cytochrome P-450	MESH:D016604	25251(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY exposed|nsubj|Effect exposed|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Effect of aflatoxin_B1 on monooxygenase activity in liver microsomes exposed to cytochrome_P-450 -RSB- .
8864187	0	aflatoxin_B1	56,68	cytochrome_P-450	18,34	aflatoxin B1	cytochrome P-450	MESH:D016604	4051	Chemical	Gene	bioactivation|amod|START_ENTITY involved|nmod|bioactivation involved|nsubj|Overexpression Overexpression|nmod|isoforms isoforms|amod|END_ENTITY	Overexpression of cytochrome_P-450 isoforms involved in aflatoxin_B1 bioactivation in human liver with cirrhosis and hepatitis .
16762476	0	aflatoxin_B1	124,136	cytochrome_P-450_1A2	47,67	aflatoxin B1	cytochrome P-450 1A2	MESH:D016604	1544	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Apiaceous vegetable constituents inhibit human cytochrome_P-450_1A2 -LRB- hCYP1A2 -RRB- activity and hCYP1A2-mediated mutagenicity of aflatoxin_B1 .
10357798	0	aflatoxin_B1	132,144	glutathione_S-transferase	40,65	aflatoxin B1	glutathione S-transferase	MESH:D016604	54486(Tax:10090)	Chemical	Gene	expressing|nsubj|START_ENTITY protects|advcl|expressing protects|nsubj|Expression Expression|nmod|A3-3 A3-3|amod|END_ENTITY	Expression of stably transfected murine glutathione_S-transferase A3-3 protects against nucleic acid alkylation and cytotoxicity by aflatoxin_B1 in hamster V79 cells expressing rat cytochrome P450-2B1 .
15019083	0	aflatoxin_B1	116,128	glutathione_S-transferase	12,37	aflatoxin B1	glutathione S-transferase	MESH:D016604	54486(Tax:10090)	Chemical	Gene	tumorigenicity|nmod|START_ENTITY contribute|nmod|tumorigenicity contribute|nsubj|END_ENTITY	Low hepatic glutathione_S-transferase and increased hepatic DNA adduction contribute to increased tumorigenicity of aflatoxin_B1 in newborn and partially hepatectomized mice .
6411367	0	aflatoxin_B1	78,90	glutathione_S-transferase	20,45	aflatoxin B1	glutathione S-transferase	MESH:D016604	58962(Tax:10116)	Chemical	Gene	conjugation|nmod|START_ENTITY END_ENTITY|nmod|conjugation	The requirement for glutathione_S-transferase in the conjugation of activated aflatoxin_B1 during aflatoxin hepatocarcinogenesis in the rat .
7379043	0	aflatoxin_B1	44,56	glutathione_S-transferase	67,92	aflatoxin B1	glutathione S-transferase	MESH:D016604	373156	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of microsome-mediated binding of aflatoxin_B1 to DNA by glutathione_S-transferase .
16762476	0	aflatoxin_B1	124,136	hCYP1A2	69,76	aflatoxin B1	hCYP1A2	MESH:D016604	1544	Chemical	Gene	activity|nmod|START_ENTITY activity|appos|END_ENTITY	Apiaceous vegetable constituents inhibit human cytochrome_P-450_1A2 -LRB- hCYP1A2 -RRB- activity and hCYP1A2-mediated mutagenicity of aflatoxin_B1 .
10472804	0	aflatoxin_B1	52,64	interleukin-2	19,32	aflatoxin B1	interleukin-2	MESH:D016604	3558	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Suppression of the interleukin-2 gene expression by aflatoxin_B1 is mediated through the down-regulation of the NF-AT and AP-1 transcription factors .
12727802	0	aflatoxin_B1_aldehyde	28,49	AKR7A1	66,72	aflatoxin B1 aldehyde	AKR7A1	null	26760(Tax:10116)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of the rat aflatoxin_B1_aldehyde reductase gene , AKR7A1 .
12076648	0	aflatoxin_epoxide	42,59	Glutathione-S-transferase	0,25	aflatoxin epoxide	Glutathione-S-transferase	null	58962(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Glutathione-S-transferase activity toward aflatoxin_epoxide in livers of mastomys and other rodents .
12086104	0	aflatoxins	46,56	isocitrate_dehydrogenase	98,122	aflatoxins	isocitrate dehydrogenase	MESH:D000348	3417	Chemical	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Effects of neem leaf extract on production of aflatoxins and activities of fatty_acid synthetase , isocitrate_dehydrogenase and glutathione_S-transferase in Aspergillus parasiticus .
19334508	0	afobazole	12,21	HSP70	44,49	afobazole	HSP70	MESH:C410924	266759(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	-LSB- Effects of afobazole on the stress protein HSP70 level in the brain tissue of rats with global transient ischemia -RSB- .
19902087	0	afobazole	10,19	monoamine_oxidase_A	37,56	afobazole	monoamine oxidase A	MESH:C410924	29253(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|compound|END_ENTITY	Effect of afobazole on mitochondrial monoamine_oxidase_A activity in vitro .
21532196	0	ageladine_A	65,76	matrix_metalloproteinase-12	14,41	ageladine A	matrix metalloproteinase-12	MESH:C482289	4321	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Synthesis and matrix_metalloproteinase-12 inhibitory activity of ageladine_A analogs .
1327822	0	aglafoline	39,49	PAF	0,3	aglafoline	PAF	MESH:C077355	300795(Tax:10116)	Chemical	Gene	antagonism|nmod|START_ENTITY antagonism|nsubj|END_ENTITY	PAF antagonism in vitro and in vivo by aglafoline from Aglaia elliptifolia Merr .
19019074	0	aglepristone	48,60	progesterone_receptor	15,36	aglepristone	progesterone receptor	MESH:C419063	100009094(Tax:9986)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|antagonist antagonist|compound|END_ENTITY	Effects of the progesterone_receptor antagonist aglepristone on implantation administered on days 6 and 7 after mating in rabbits .
24461723	0	agmatine	85,93	Neuropeptide_Y	0,14	agmatine	Neuropeptide Y	MESH:D000376	24604(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY regulates|dobj|effect regulates|nsubj|END_ENTITY	Neuropeptide_Y in the central nucleus of amygdala regulates the anxiolytic effect of agmatine in rats .
21404211	0	agmatine	75,83	agmatine_deiminase	88,106	agmatine	agmatine deiminase	MESH:D000376	879730(Tax:208964)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of two families of bacterial enzymes in putrescine synthesis from agmatine via agmatine_deiminase .
8584654	0	agmatine	14,22	diamine_oxidase	59,74	agmatine	diamine oxidase	MESH:D000376	65029(Tax:10116)	Chemical	Gene	Metabolism|nmod|START_ENTITY Metabolism|nmod|END_ENTITY	Metabolism of agmatine -LRB- clonidine-displacing substance -RRB- by diamine_oxidase and the possible implications for studies of imidazoline receptors .
11160620	0	agmatine	74,82	ornithine_decarboxylase	14,37	agmatine	ornithine decarboxylase	MESH:D000376	24609(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Regulation of ornithine_decarboxylase activity and polyamine transport by agmatine in rat pulmonary artery endothelial cells .
25655388	0	agmatine	74,82	ornithine_decarboxylase	13,36	agmatine	ornithine decarboxylase	MESH:D000376	4953	Chemical	Gene	uptake|amod|START_ENTITY inhibitors|nmod|uptake inhibitors|nsubj|Influence Influence|nmod|antizymes antizymes|amod|END_ENTITY	Influence of ornithine_decarboxylase antizymes and antizyme inhibitors on agmatine uptake by mammalian cells .
14552590	0	agosterol_A	82,93	P-glycoprotein	19,33	agosterol A	P-glycoprotein	MESH:C429345	5243	Chemical	Gene	analog|nmod|START_ENTITY END_ENTITY|nmod|analog	Binding site -LRB- s -RRB- on P-glycoprotein for a newly synthesized photoaffinity analog of agosterol_A .
15019157	0	ajoene	38,44	caspase-3	127,136	ajoene	caspase-3	MESH:C048980	12367(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|role role|nmod|END_ENTITY	Apoptotic and anti-adhesion effect of ajoene , a garlic derived compound , on the murine melanoma B16F10 cells : possible role of caspase-3 and the alpha -LRB- 4 -RRB- beta -LRB- 1 -RRB- integrin .
9048900	0	ajoene	14,20	protein_tyrosine_phosphatase	24,52	ajoene	protein tyrosine phosphatase	MESH:C048980	26191	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activity activity|amod|END_ENTITY	Inhibition by ajoene of protein_tyrosine_phosphatase activity in human platelets .
12566094	0	ajulemic_acid	62,75	interleukin-1beta	30,47	ajulemic acid	interleukin-1beta	MESH:C471849	3553	Chemical	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Suppression of human monocyte interleukin-1beta production by ajulemic_acid , a nonpsychoactive cannabinoid .
12695526	0	ajulemic_acid	100,113	peroxisome_proliferator-activated_receptor_gamma	26,74	ajulemic acid	peroxisome proliferator-activated receptor gamma	MESH:C471849	5468	Chemical	Gene	START_ENTITY|nsubj|Activation Activation|nmod|END_ENTITY	Activation and binding of peroxisome_proliferator-activated_receptor_gamma by synthetic cannabinoid ajulemic_acid .
10221351	0	alacepril	30,39	angiotensin-converting_enzyme	44,73	alacepril	angiotensin-converting enzyme	null	1636	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Antiatherosclerotic effect of alacepril , an angiotensin-converting_enzyme inhibitor , in monkeys fed a high-cholesterol diet .
8651088	0	alacepril	51,60	angiotensin-converting_enzyme	11,40	alacepril	angiotensin-converting enzyme	null	1636	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Effects of angiotensin-converting_enzyme inhibitor alacepril in patients with stable effort angina during chronic isosorbide_dinitrate treatment .
8531099	0	aladotril	56,65	neutral_endopeptidase	88,109	aladotril	neutral endopeptidase	null	24590(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|inhibitor inhibitor|nmod|END_ENTITY	Hemodynamic effects of acute and chronic treatment with aladotril , a mixed inhibitor of neutral_endopeptidase and angiotensin_I-converting_enzyme , in conscious rats with myocardial_infarction .
11824937	0	alanine	20,27	ASCT1	64,69	alanine	ASCT1	CHEBI:16449	6509	Chemical	Gene	transport|nmod|START_ENTITY transport|nmod|END_ENTITY	Active transport of alanine by the neutral amino-acid exchanger ASCT1 .
16957471	0	alanine	84,91	COL2A1	112,118	alanine	COL2A1	CHEBI:16449	1280	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	A form of autosomal_dominant_spondyloepiphyseal_dysplasia is caused by a glycine to alanine substitution in the COL2A1 gene .
11553629	0	alanine	172,179	COT	168,171	alanine	COT	CHEBI:16449	83842(Tax:10116)	Chemical	Gene	impairs|compound|START_ENTITY impairs|compound|END_ENTITY	Structural model of the catalytic core of carnitine_palmitoyltransferase_I and carnitine_octanoyltransferase -LRB- COT -RRB- : mutation of CPT_I_histidine 473 and alanine 381 and COT alanine 238 impairs the catalytic activity .
23344727	0	alanine	19,26	Insulin	131,138	alanine	Insulin	CHEBI:16449	3630	Chemical	Gene	aminotransferase|amod|START_ENTITY association|nmod|aminotransferase association|dep|Resistance Resistance|amod|END_ENTITY	The association of alanine aminotransferase within the normal and mildly elevated range with lipoproteins and apolipoproteins : the Insulin Resistance Atherosclerosis Study .
10381364	0	alanine	53,60	MAL	81,84	alanine	MAL	CHEBI:16449	403933(Tax:9615)	Chemical	Gene	retention|amod|START_ENTITY retention|nmod|END_ENTITY	Substitution of the two carboxyl-terminal serines by alanine causes retention of MAL , a component of the apical sorting machinery , in the endoplasmic reticulum .
19058226	0	alanine	29,36	PHOX2B	37,43	alanine	PHOX2B	CHEBI:16449	8929	Chemical	Gene	mutations|amod|START_ENTITY mutations|compound|END_ENTITY	In Vitro studies of non poly alanine PHOX2B mutations argue against a loss-of-function mechanism for congenital_central_hypoventilation .
14514601	0	alanine	60,67	PPARgamma	97,106	alanine	PPARgamma	CHEBI:16449	5468	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Prospective study of the association between the proline to alanine codon 12 polymorphism in the PPARgamma gene and type 2 diabetes .
6540208	0	alanine	32,39	VIP	11,14	alanine	VIP	CHEBI:16449	117064(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY Effects|nmod|metabolism Effects|nmod|END_ENTITY	Effects of VIP and forskolin on alanine metabolism in isolated hepatocytes .
7761626	0	alanine	54,61	VIP	39,42	alanine	VIP	CHEBI:16449	117064(Tax:10116)	Chemical	Gene	absorption|compound|START_ENTITY Effects|nmod|absorption Effects|nmod|END_ENTITY	Effects of intracerebral injections of VIP on jejunal alanine absorption and gastric_acid secretion in rats .
1199243	0	alanine	9,16	aminopeptidase	17,31	alanine	aminopeptidase	CHEBI:16449	10404	Chemical	Gene	START_ENTITY|dobj|excretion excretion|amod|END_ENTITY	-LSB- Urinary alanine aminopeptidase and lysozyme excretion in patients with diabetes -RSB- .
1680783	0	alanine	32,39	aminopeptidase	40,54	alanine	aminopeptidase	CHEBI:16449	10404	Chemical	Gene	evaluation|nmod|START_ENTITY END_ENTITY|nsubj|evaluation	-LSB- Clinical evaluation of urinary alanine aminopeptidase in the patients with diabetes_mellitus-comparison among AAP microalbumin and N-acetyl-beta-D-glucosaminidase -RSB- .
1686729	0	alanine	21,28	aminopeptidase	29,43	alanine	aminopeptidase	CHEBI:16449	10404	Chemical	Gene	rhythms|nmod|START_ENTITY END_ENTITY|nsubj|rhythms	Infradian rhythms of alanine aminopeptidase excretion during gentamicin therapy .
1688253	0	alanine	25,32	aminopeptidase	33,47	alanine	aminopeptidase	CHEBI:16449	10404	Chemical	Gene	evaluation|nmod|START_ENTITY END_ENTITY|nsubj|evaluation	Diagnostic evaluation of alanine aminopeptidase as serum marker for detecting cancer .
1698011	0	alanine	99,106	aminopeptidase	107,121	alanine	aminopeptidase	CHEBI:16449	10404	Chemical	Gene	START_ENTITY|dobj|protein protein|amod|END_ENTITY	-LSB- Urinary excretion of glycine.prolile dipeptidile aminopeptidase , N-acetyl-beta-D-glucosaminidase , alanine aminopeptidase and low molecular protein in patients with renal_cell_carcinoma -RSB- .
1698011	0	alanine	99,106	aminopeptidase	50,64	alanine	aminopeptidase	CHEBI:16449	10404	Chemical	Gene	START_ENTITY|nsubj|excretion excretion|nmod|END_ENTITY	-LSB- Urinary excretion of glycine.prolile dipeptidile aminopeptidase , N-acetyl-beta-D-glucosaminidase , alanine aminopeptidase and low molecular protein in patients with renal_cell_carcinoma -RSB- .
22796679	0	alanine	87,94	aminopeptidase	95,109	alanine	aminopeptidase	CHEBI:16449	10404	Chemical	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Development of a primer system to study abundance and diversity of the gene coding for alanine aminopeptidase pepN gene in Gram-negative soil bacteria .
2866856	0	alanine	43,50	aminopeptidase	51,65	alanine	aminopeptidase	CHEBI:16449	10404	Chemical	Gene	START_ENTITY|dobj|activity activity|amod|END_ENTITY	Significance of the measurement of urinary alanine aminopeptidase and N-acetyl-beta-D-glucosaminidase activity in evaluating patients with essential hypertension .
2899408	0	alanine	24,31	aminopeptidase	32,46	alanine	aminopeptidase	CHEBI:16449	10404	Chemical	Gene	excretion|amod|START_ENTITY excretion|amod|END_ENTITY	The increase in urinary alanine aminopeptidase excretion associated with enflurane anesthesia is increased further by aminoglycosides .
38	0	alanine	73,80	aminopeptidase	81,95	alanine	aminopeptidase	CHEBI:16449	10404	Chemical	Gene	constants|nmod|START_ENTITY pH|nmod|constants Effect|nmod|pH END_ENTITY|nsubj|Effect	Effect of pH on substrate and inhibitor kinetic constants of human liver alanine aminopeptidase .
606559	0	alanine	18,25	aminopeptidase	50,64	alanine	aminopeptidase	CHEBI:16449	10404	Chemical	Gene	aminopeptidase|amod|START_ENTITY activities|nmod|aminopeptidase leucine|nsubj|activities leucine|dobj|dipeptidase dipeptidase|amod|END_ENTITY	The activities of alanine aminopeptidase , leucine aminopeptidase , proline_dipeptidase and prolyl dipeptidase in the mucosa of the small intestine .
6105021	0	alanine	22,29	aminopeptidase	30,44	alanine	aminopeptidase	CHEBI:16449	10404	Chemical	Gene	assay|nmod|START_ENTITY END_ENTITY|nsubj|assay	An optimized assay of alanine aminopeptidase activity in urine .
6122635	0	alanine	42,49	aminopeptidase	50,64	alanine	aminopeptidase	CHEBI:16449	10404	Chemical	Gene	START_ENTITY|dobj|elastase_and_myeloperoxidase elastase_and_myeloperoxidase|amod|collagenase collagenase|amod|END_ENTITY	Separation of the human leucocyte enzymes alanine aminopeptidase , cathepsin_G , _ collagenase , _ elastase_and_myeloperoxidase .
6133385	0	alanine	13,20	aminopeptidase	21,35	alanine	aminopeptidase	CHEBI:16449	397520(Tax:9823)	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	-LSB- Leucine and alanine aminopeptidase activity in the organs of cattle , sheep and swine -RSB- .
6151808	0	alanine	8,15	aminopeptidase	16,30	alanine	aminopeptidase	CHEBI:16449	10404	Chemical	Gene	START_ENTITY|dobj|activity activity|amod|END_ENTITY	Urinary alanine aminopeptidase activity in various urinary_tract_diseases .
6151965	0	alanine	9,16	aminopeptidase	17,31	alanine	aminopeptidase	CHEBI:16449	10404	Chemical	Gene	START_ENTITY|dobj|excretion excretion|amod|END_ENTITY	-LSB- Urinary alanine aminopeptidase excretion in children : reference values and effect of nephrotropic contrast media -RSB- .
6152536	0	alanine	81,88	aminopeptidase	89,103	alanine	aminopeptidase	CHEBI:16449	10404	Chemical	Gene	START_ENTITY|dobj|phosphatase phosphatase|amod|END_ENTITY	Characterization of particulate and soluble variants of the brush-border enzymes alanine aminopeptidase , alkaline phosphatase and gamma-glutamyltransferase in human urine .
7576235	0	alanine	21,28	aminopeptidase	29,43	alanine	aminopeptidase	CHEBI:16449	10404	Chemical	Gene	Identification|nmod|START_ENTITY END_ENTITY|nsubj|Identification	Identification of an alanine aminopeptidase in human maternal serum as a membrane-bound aminopeptidase N .
7576235	0	alanine	21,28	aminopeptidase	88,102	alanine	aminopeptidase	CHEBI:16449	10404	Chemical	Gene	Identification|nmod|START_ENTITY aminopeptidase|nsubj|Identification aminopeptidase|nmod|serum serum|nmod|N N|compound|END_ENTITY	Identification of an alanine aminopeptidase in human maternal serum as a membrane-bound aminopeptidase N .
954716	0	alanine	32,39	aminopeptidase	40,54	alanine	aminopeptidase	CHEBI:16449	10404	Chemical	Gene	forms|nmod|START_ENTITY Nature|nmod|forms END_ENTITY|nsubj|Nature	Nature of the multiple forms of alanine aminopeptidase .
8662595	1	alanine	260,267	hLIF	288,292	alanine	hLIF	CHEBI:16449	3976	Chemical	Gene	mutants|amod|START_ENTITY mutants|nmod|END_ENTITY	Residues in human leukemia_inhibitory_factor -LRB- hLIF -RRB- crucial for binding to both the human LIF_receptor _ -LRB- R -RRB- and gp130 were identified by analysis of alanine scanning mutants of hLIF in assays for both receptor binding and bioactivity .
11161109	0	alanine	40,47	insulin	90,97	alanine	insulin	CHEBI:16449	3630	Chemical	Gene	obtained|nmod|START_ENTITY obtained|xcomp|scanning scanning|dobj|surface surface|nmod|molecule molecule|compound|END_ENTITY	Four new monomeric insulins obtained by alanine scanning the dimer-forming surface of the insulin molecule .
20085121	0	alanine	63,70	insulin	16,23	alanine	insulin	CHEBI:16449	3630	Chemical	Gene	resistance|nmod|START_ENTITY resistance|compound|END_ENTITY	Relationship of insulin resistance and adipocytokines on serum alanine aminotransferase in presurgical morbid obese patients .
23884827	0	alanine	55,62	insulin	8,15	alanine	insulin	CHEBI:16449	3630	Chemical	Gene	resistance|nmod|START_ENTITY resistance|compound|END_ENTITY	Role of insulin resistance and adipocytokines on serum alanine aminotransferase in obese patients with type_2_diabetes_mellitus .
3275858	0	alanine	10,17	insulin	58,65	alanine	insulin	CHEBI:16449	483665(Tax:9615)	Chemical	Gene	independent|amod|START_ENTITY independent|nmod|changes changes|nmod|END_ENTITY	Effect of alanine concentration independent of changes in insulin and glucagon on alanine and glucose homeostasis in the conscious dog .
3275858	0	alanine	82,89	insulin	58,65	alanine	insulin	CHEBI:16449	483665(Tax:9615)	Chemical	Gene	homeostasis|compound|START_ENTITY Effect|nmod|homeostasis Effect|nmod|independent independent|nmod|changes changes|nmod|END_ENTITY	Effect of alanine concentration independent of changes in insulin and glucagon on alanine and glucose homeostasis in the conscious dog .
3315797	0	alanine	51,58	insulin	25,32	alanine	insulin	CHEBI:16449	483665(Tax:9615)	Chemical	Gene	rates|amod|START_ENTITY administration|nmod|rates administration|compound|END_ENTITY	The effect of prehepatic insulin administration on alanine flux rates in diabetic dogs .
680628	0	alanine	40,47	insulin	56,63	alanine	insulin	CHEBI:16449	483665(Tax:9615)	Chemical	Gene	effect|nmod|START_ENTITY effect|acl|induced induced|dobj|secretion secretion|compound|END_ENTITY	The effect of altered autonomic tone on alanine induced insulin secretion .
6997676	0	alanine	62,69	insulin	11,18	alanine	insulin	CHEBI:16449	3630	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of insulin at two dose levels on gluconeogenesis from alanine in fasting man .
7006399	0	alanine	46,53	insulin	21,28	alanine	insulin	CHEBI:16449	3630	Chemical	Gene	concentration|compound|START_ENTITY release|nmod|concentration release|nsubj|Effect Effect|nmod|END_ENTITY	Effect of endogenous insulin release on fetal alanine concentration and uptake .
7356691	0	alanine	80,87	insulin	45,52	alanine	insulin	CHEBI:16449	483665(Tax:9615)	Chemical	Gene	metabolism|amod|START_ENTITY Effect|nmod|metabolism Effect|appos|independent independent|nmod|changes changes|nmod|secretion secretion|compound|END_ENTITY	Effect of glucose , independent of changes in insulin and glucagon secretion , on alanine metabolism in the conscious dog .
9347802	0	alanine	3,10	keratin_10	59,69	alanine	keratin 10	CHEBI:16449	3858	Chemical	Gene	START_ENTITY|nmod|chain chain|amod|END_ENTITY	An alanine to proline mutation in the 1A rod domain of the keratin_10 chain in epidermolytic_hyperkeratosis .
23634215	0	alanine	10,17	l17	33,36	alanine	l17	CHEBI:16449	6139	Chemical	Gene	replacement|amod|START_ENTITY Effect|nmod|replacement Effect|nmod|END_ENTITY	Effect of alanine replacement of l17 and f19 on the aggregation and neurotoxicity of arctic-type ab40 .
22796679	0	alanine	87,94	pepN	110,114	alanine	pepN	CHEBI:16449	290	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Development of a primer system to study abundance and diversity of the gene coding for alanine aminopeptidase pepN gene in Gram-negative soil bacteria .
17708846	0	alanyl-glutamine	37,53	HSP70	80,85	alanyl-glutamine	HSP70	MESH:C054122	3308	Chemical	Gene	START_ENTITY|dobj|expression expression|compound|END_ENTITY	-LSB- Effect of early enriched parenteral alanyl-glutamine on heat_shock protein 70 -LRB- HSP70 -RRB- expression in critical patients -RSB- .
8035346	0	alatriopril	11,22	atriopeptidase	45,59	alatriopril	atriopeptidase	MESH:C068866	24590(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|inhibitor inhibitor|nmod|END_ENTITY	Effects of alatriopril , a mixed inhibitor of atriopeptidase and angiotensin_I-converting_enzyme , on cardiac_hypertrophy and hormonal responses in rats with myocardial_infarction .
19592625	0	albiglutide	13,24	GLP-1_receptor	40,54	albiglutide	GLP-1 receptor	MESH:C534611	2740	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Potential of albiglutide , a long-acting GLP-1_receptor agonist , in type 2 diabetes : a randomized controlled trial exploring weekly , biweekly , and monthly dosing .
15219176	0	albuterol	86,95	COPD	117,121	albuterol	COPD	MESH:D000420	260431	Chemical	Gene	START_ENTITY|nmod|treatment treatment|nmod|END_ENTITY	A short-term comparison of fluticasone_propionate / salmeterol with ipratropium_bromide / albuterol for the treatment of COPD .
19514054	0	albuterol	58,67	GSNOR	20,25	albuterol	GSNOR	MESH:D000420	128	Chemical	Gene	influence|advcl|START_ENTITY influence|nsubj|variants variants|nmod|END_ENTITY	Genetic variants of GSNOR and ADRB2 influence response to albuterol in African-American children with severe asthma .
21320165	0	albuterol	22,31	RANTES	49,55	albuterol	RANTES	MESH:D000420	6352	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Inhibitory effects of albuterol and fenoterol on RANTES and IP-10 expression in bronchial epithelial cells .
426077	0	albuterol	13,22	erythropoietin	26,40	albuterol	erythropoietin	MESH:D000420	100008786(Tax:9986)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|production production|compound|END_ENTITY	Influence of albuterol on erythropoietin production and erythroid progenitor cell activation .
2880597	0	alcohol	51,58	A-II	21,25	alcohol	A-II	CHEBI:16236	114548	Chemical	Gene	intake|compound|START_ENTITY END_ENTITY|nmod|intake	Serum apolipoprotein A-II as a marker of change in alcohol intake in male drinkers .
2169444	0	alcohol	24,31	ADH1	52,56	alcohol	ADH1	CHEBI:16236	124	Chemical	Gene	Promoters|nmod|START_ENTITY dehydrogenase|nsubj|Promoters dehydrogenase|xcomp|genes genes|nummod|END_ENTITY	Promoters for the human alcohol dehydrogenase genes ADH1 , ADH2 , and ADH3 : interaction of CCAAT/enhancer-binding protein with elements flanking the ADH2 TATA box .
8634148	0	alcohol	104,111	ADH1	132,136	alcohol	ADH1	CHEBI:16236	124	Chemical	Gene	dehydrogenase|compound|START_ENTITY expression|nmod|dehydrogenase differences|nmod|expression genes|dep|differences genes|nummod|END_ENTITY	Gene expression in a young multigene family : tissue-specific differences in the expression of the human alcohol dehydrogenase genes ADH1 , ADH2 , and ADH3 .
12244546	0	alcohol	35,42	ADH1B	13,18	alcohol	ADH1B	CHEBI:16236	125	Chemical	Gene	use|compound|START_ENTITY polymorphism|nmod|use polymorphism|nsubj|Influence Influence|nmod|END_ENTITY	Influence of ADH1B polymorphism on alcohol use and its subjective effects in a Jewish population .
12884000	0	alcohol	21,28	ADH1B	48,53	alcohol	ADH1B	CHEBI:16236	125	Chemical	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	Allelic variation at alcohol metabolism genes -LRB- ADH1B , ADH1C , ALDH2 -RRB- and alcohol_dependence in an American Indian population .
15886702	0	alcohol	43,50	ADH1B	26,31	alcohol	ADH1B	CHEBI:16236	125	Chemical	Gene	consumption|compound|START_ENTITY risk|nsubj|consumption risk|ccomp|genotype genotype|nsubj|Alcohol_dehydrogenase_1B Alcohol_dehydrogenase_1B|appos|END_ENTITY	Alcohol_dehydrogenase_1B -LRB- ADH1B -RRB- genotype , alcohol consumption and breast_cancer risk by age 50 years in a German case-control study .
16086315	0	alcohol	31,38	ADH1B	56,61	alcohol	ADH1B	CHEBI:16236	125	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Scanning of genetic effects of alcohol metabolism gene -LRB- ADH1B and ADH1C -RRB- polymorphisms on the risk of alcoholism .
16184481	0	alcohol	64,71	ADH1B	159,164	alcohol	ADH1B	CHEBI:16236	125	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|acl|predicted predicted|nmod|studies studies|nmod|polymorphism polymorphism|nmod|loci loci|compound|END_ENTITY	Genetic time-series analysis identifies a major QTL for in vivo alcohol metabolism not predicted by in vitro studies of structural protein polymorphism at the ADH1B or ADH1C loci .
17207821	0	alcohol	21,28	ADH1B	74,79	alcohol	ADH1B	CHEBI:16236	125	Chemical	Gene	effects|nmod|START_ENTITY modulated|nsubj|effects modulated|nmod|polymorphisms polymorphisms|compound|END_ENTITY	Genotoxic effects of alcohol in human peripheral lymphocytes modulated by ADH1B and ALDH2 gene polymorphisms .
17559546	0	alcohol	28,35	ADH1B	10,15	alcohol	ADH1B	CHEBI:16236	125	Chemical	Gene	consumption|compound|START_ENTITY genotype|nmod|consumption genotype|nsubj|Effect Effect|nmod|END_ENTITY	Effect of ADH1B genotype on alcohol consumption in young Israeli Jews .
19449376	0	alcohol	67,74	ADH1B	22,27	alcohol	ADH1B	CHEBI:16236	125	Chemical	Gene	consumption|compound|START_ENTITY regard|nmod|consumption polymorphisms|advcl|regard polymorphisms|nsubj|modulation modulation|nmod|END_ENTITY	Genetic modulation of ADH1B and ALDH2 polymorphisms with regard to alcohol and tobacco consumption for younger aged esophageal_squamous_cell_carcinoma diagnosis .
19687126	0	alcohol	71,78	ADH1B	28,33	alcohol	ADH1B	CHEBI:16236	125	Chemical	Gene	use|compound|START_ENTITY associated|nmod|use associated|nsubjpass|variant variant|nmod|END_ENTITY	A non-synonymous variant in ADH1B is strongly associated with prenatal alcohol use in a European sample of pregnant women .
19698717	0	alcohol	52,59	ADH1B	23,28	alcohol	ADH1B	CHEBI:16236	125	Chemical	Gene	synergistically|compound|START_ENTITY coupled|nmod|synergistically variants|acl|coupled variants|nmod|END_ENTITY	Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal_cancer risk .
20477764	0	alcohol	24,31	ADH1B	0,5	alcohol	ADH1B	CHEBI:16236	125	Chemical	Gene	*|nmod|START_ENTITY *|nsubj|END_ENTITY	ADH1B * 3 and response to alcohol in African-Americans .
20833657	0	alcohol	42,49	ADH1B	136,141	alcohol	ADH1B	CHEBI:16236	125	Chemical	Gene	consumption|compound|START_ENTITY effects|nmod|consumption interaction|nmod|effects interaction|nmod|individuals individuals|nmod|alleles alleles|compound|END_ENTITY	Strong interaction between the effects of alcohol consumption and smoking on oesophageal_squamous_cell_carcinoma among individuals with ADH1B and/or ALDH2 risk alleles .
21284671	0	alcohol	132,139	ADH1B	33,38	alcohol	ADH1B	CHEBI:16236	125	Chemical	Gene	consumption|compound|START_ENTITY esophageal_cancers|nmod|consumption protection|nmod|esophageal_cancers protection|dep|protection protection|nmod|END_ENTITY	Acetaldehyde burst protection of ADH1B * 2 against alcoholism : an additional hormesis protection against esophageal_cancers following alcohol consumption ?
22144473	0	alcohol	107,114	ADH1B	51,56	alcohol	ADH1B	CHEBI:16236	125	Chemical	Gene	consumption|compound|START_ENTITY cohort|nsubj|consumption cohort|nsubj|variation variation|nmod|alcohol_dehydrogenase alcohol_dehydrogenase|appos|ADH1A ADH1A|dep|END_ENTITY	Genetic variation in alcohol_dehydrogenase -LRB- ADH1A , ADH1B , ADH1C , ADH7 -RRB- and aldehyde_dehydrogenase -LRB- ALDH2 -RRB- , alcohol consumption and gastric_cancer risk in the European Prospective Investigation into Cancer and Nutrition -LRB- EPIC -RRB- cohort .
22150722	0	alcohol	20,27	ADH1B	0,5	alcohol	ADH1B	CHEBI:16236	125	Chemical	Gene	consumption|compound|START_ENTITY polymorphism|appos|consumption polymorphism|compound|END_ENTITY	ADH1B polymorphism , alcohol consumption , and binge drinking in Slavic Caucasians : results from the Czech HAPIEE study .
24282520	0	alcohol	17,24	ADH1B	42,47	alcohol	ADH1B	CHEBI:16236	125	Chemical	Gene	genes|compound|START_ENTITY Polymorphisms|nmod|genes Polymorphisms|dep|END_ENTITY	Polymorphisms in alcohol metabolism genes ADH1B and ALDH2 , alcohol consumption and colorectal_cancer .
24797321	0	alcohol	33,40	ADH1B	55,60	alcohol	ADH1B	CHEBI:16236	125	Chemical	Gene	dehydrogenase|compound|START_ENTITY variant|nmod|dehydrogenase Effect|nmod|variant END_ENTITY|nsubj|Effect	Effect of the allelic variant of alcohol dehydrogenase ADH1B * 2 on ethanol metabolism .
25410943	4	alcohol	853,860	ADH1B	811,816	alcohol	ADH1B	CHEBI:16236	125	Chemical	Gene	dependence|compound|START_ENTITY tested|nmod|dependence tested|dobj|polymorphisms polymorphisms|nummod|END_ENTITY	We tested the most significant ADH1B single nucleotide polymorphisms for alcohol dependence from a genomewide association study with this sample , ADH1B-rs1229984 -LRB- Arg48His -RRB- and ADH1B-rs2066702 -LRB- Arg370Cys -RRB- , in EA and AA subsamples , respectively .
26825972	0	alcohol	102,109	ADH1B	43,48	alcohol	ADH1B	D000431	125	Chemical	Gene	sensitivity|compound|START_ENTITY genotypes|nmod|sensitivity genotypes|nsubj|Relationships Relationships|nmod|alcohol_dehydrogenase_1B alcohol_dehydrogenase_1B|appos|END_ENTITY	Relationships of alcohol_dehydrogenase_1B -LRB- ADH1B -RRB- and aldehyde_dehydrogenase_2 -LRB- ALDH2 -RRB- genotypes with alcohol sensitivity , drinking behavior and problem drinking in Japanese older men .
10737710	0	alcohol	21,28	ADH2	39,43	alcohol	ADH2	CHEBI:16236	125	Chemical	Gene	drinking|compound|START_ENTITY Relationship|nmod|drinking genotypes|ccomp|Relationship genotypes|nsubj|END_ENTITY	Relationship between alcohol drinking , ADH2 and ALDH2 genotypes , and risk for hepatocellular_carcinoma in Japanese .
11306056	0	alcohol	9,16	ADH2	32,36	alcohol	ADH2	CHEBI:16236	26876(Tax:10090)	Chemical	Gene	dehydrogenase|compound|START_ENTITY dehydrogenase|appos|END_ENTITY	Class II alcohol dehydrogenase -LRB- ADH2 -RRB- -- adding the structure .
16187278	0	alcohol	13,20	ADH2	59,63	alcohol	ADH2	CHEBI:16236	125	Chemical	Gene	consumption|compound|START_ENTITY Influence|nmod|consumption Influence|nmod|END_ENTITY	Influence of alcohol consumption and gene polymorphisms of ADH2 and ALDH2 on hepatocellular_carcinoma in a Japanese population .
2169444	0	alcohol	24,31	ADH2	147,151	alcohol	ADH2	CHEBI:16236	125	Chemical	Gene	Promoters|nmod|START_ENTITY dehydrogenase|nsubj|Promoters dehydrogenase|parataxis|flanking flanking|dobj|box box|compound|END_ENTITY	Promoters for the human alcohol dehydrogenase genes ADH1 , ADH2 , and ADH3 : interaction of CCAAT/enhancer-binding protein with elements flanking the ADH2 TATA box .
2169444	0	alcohol	24,31	ADH2	58,62	alcohol	ADH2	CHEBI:16236	125	Chemical	Gene	Promoters|nmod|START_ENTITY dehydrogenase|nsubj|Promoters dehydrogenase|xcomp|genes genes|nummod|END_ENTITY	Promoters for the human alcohol dehydrogenase genes ADH1 , ADH2 , and ADH3 : interaction of CCAAT/enhancer-binding protein with elements flanking the ADH2 TATA box .
395099	0	alcohol	6,13	ADH2	28,32	alcohol	ADH2	CHEBI:16236	125	Chemical	Gene	dehydrogenase|nsubj|START_ENTITY dehydrogenase|dobj|polymorphisms polymorphisms|compound|END_ENTITY	Human alcohol dehydrogenase ADH2 and ADH3 polymorphisms in ethnic Chinese and Indians of West_Malaysia .
6370230	0	alcohol	28,35	ADH2	69,73	alcohol	ADH2	CHEBI:16236	125	Chemical	Gene	dehydrogenase|compound|START_ENTITY Polymorphism|nmod|dehydrogenase Polymorphism|dep|identification identification|nmod|2-1 2-1|nummod|END_ENTITY	Polymorphism of human liver alcohol dehydrogenase : identification of ADH2 2-1 and ADH2 2-2 phenotypes in the Japanese by isoelectric focusing .
7943668	0	alcohol	71,78	ADH2	21,25	alcohol	ADH2	CHEBI:16236	125	Chemical	Gene	disorders|compound|START_ENTITY allele|nmod|disorders allele|nsubj|frequency frequency|nmod|END_ENTITY	Low frequency of the ADH2 * 2 allele among Atayal natives of Taiwan with alcohol use disorders .
8172654	0	alcohol	64,71	ADH2	59,63	alcohol	ADH2	CHEBI:16236	125	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Tissue-specific differences in the expression of the human ADH2 alcohol dehydrogenase gene and in binding of factors to cis-acting elements in its promoter .
8591846	0	alcohol	54,61	ADH2	18,22	alcohol	ADH2	CHEBI:16236	125	Chemical	Gene	dependents|compound|START_ENTITY genes|nmod|dependents 1/ALDH2|dobj|genes 1/ALDH2|nsubj|incidence incidence|nmod|END_ENTITY	High incidence of ADH2 * 1/ALDH2 * 1 genes among Japanese alcohol dependents and patients with alcoholic_liver_disease .
8634148	0	alcohol	104,111	ADH2	138,142	alcohol	ADH2	CHEBI:16236	125	Chemical	Gene	dehydrogenase|compound|START_ENTITY expression|nmod|dehydrogenase differences|nmod|expression genes|dep|differences genes|nummod|END_ENTITY	Gene expression in a young multigene family : tissue-specific differences in the expression of the human alcohol dehydrogenase genes ADH1 , ADH2 , and ADH3 .
8749816	0	alcohol	44,51	ADH2	0,4	alcohol	ADH2	CHEBI:16236	125	Chemical	Gene	pharmacokinetics|compound|START_ENTITY determinants|nmod|pharmacokinetics determinants|nsubj|polymorphisms polymorphisms|compound|END_ENTITY	ADH2 gene polymorphisms are determinants of alcohol pharmacokinetics .
16344274	0	alcohol	15,22	ADH3	0,4	alcohol	ADH3	CHEBI:16236	126	Chemical	Gene	intake|compound|START_ENTITY genotype|appos|intake genotype|nummod|END_ENTITY	ADH3 genotype , alcohol intake and breast_cancer risk .
16431092	0	alcohol	66,73	ADH3	57,61	alcohol	ADH3	CHEBI:16236	11529(Tax:10090)	Chemical	Gene	alcohol_dehydrogenase|nmod|START_ENTITY alcohol_dehydrogenase|appos|END_ENTITY	In vivo contribution of Class III alcohol_dehydrogenase -LRB- ADH3 -RRB- to alcohol metabolism through activation by cytoplasmic solution hydrophobicity .
19489444	0	alcohol	16,23	ADH3	89,93	alcohol	ADH3	CHEBI:16236	11529(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY sight|nmod|metabolism sight|dep|role role|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- A new sight on alcohol metabolism and alcoholism -- role of high Km alcohol dehydrogenase ADH3 -LRB- Class III -RRB- -RSB- .
19489444	0	alcohol	67,74	ADH3	89,93	alcohol	ADH3	CHEBI:16236	11529(Tax:10090)	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- A new sight on alcohol metabolism and alcoholism -- role of high Km alcohol dehydrogenase ADH3 -LRB- Class III -RRB- -RSB- .
20617019	0	alcohol	14,21	ADH3	102,106	alcohol	ADH3	CHEBI:16236	11529(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY view|nmod|metabolism view|dep|role role|nmod|dehydrogenase dehydrogenase|appos|END_ENTITY	A new view of alcohol metabolism and alcoholism -- role of the high-Km Class III alcohol dehydrogenase -LRB- ADH3 -RRB- .
20617019	0	alcohol	79,86	ADH3	102,106	alcohol	ADH3	CHEBI:16236	11529(Tax:10090)	Chemical	Gene	dehydrogenase|compound|START_ENTITY dehydrogenase|appos|END_ENTITY	A new view of alcohol metabolism and alcoholism -- role of the high-Km Class III alcohol dehydrogenase -LRB- ADH3 -RRB- .
25223084	0	alcohol	43,50	ADH3	99,103	alcohol	ADH3	CHEBI:16236	126	Chemical	Gene	pathway|nmod|START_ENTITY metabolism|amod|pathway metabolism|appos|END_ENTITY	-LSB- Molecular evidences of non-ADH pathway in alcohol metabolism and Class III_alcohol dehydrogenase -LRB- ADH3 -RRB- -RSB- .
2943982	0	alcohol	89,96	ADH3	30,34	alcohol	ADH3	CHEBI:16236	855107(Tax:4932)	Chemical	Gene	isozyme|nmod|START_ENTITY encoding|dobj|isozyme gene|acl|encoding END_ENTITY|appos|gene	Isolation and DNA sequence of ADH3 , a nuclear gene encoding the mitochondrial isozyme of alcohol dehydrogenase in Saccharomyces_cerevisiae .
17921519	0	alcohol	77,84	ADH7	54,58	alcohol	ADH7	CHEBI:16236	131	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	Association of the gastric_alcohol_dehydrogenase gene ADH7 with variation in alcohol metabolism .
22144473	0	alcohol	107,114	ADH7	65,69	alcohol	ADH7	CHEBI:16236	131	Chemical	Gene	consumption|compound|START_ENTITY cohort|nsubj|consumption cohort|nsubj|variation variation|nmod|alcohol_dehydrogenase alcohol_dehydrogenase|appos|ADH1A ADH1A|dep|END_ENTITY	Genetic variation in alcohol_dehydrogenase -LRB- ADH1A , ADH1B , ADH1C , ADH7 -RRB- and aldehyde_dehydrogenase -LRB- ALDH2 -RRB- , alcohol consumption and gastric_cancer risk in the European Prospective Investigation into Cancer and Nutrition -LRB- EPIC -RRB- cohort .
12592711	0	alcohol	46,53	ADHFe1	74,80	alcohol	ADHFe1	CHEBI:16236	137872	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Cloning and characterization of a novel human alcohol dehydrogenase gene -LRB- ADHFe1 -RRB- .
12423374	0	alcohol	65,72	ADHVII	88,94	alcohol	ADHVII	CHEBI:16236	850469(Tax:4932)	Chemical	Gene	dehydrogenase|compound|START_ENTITY dehydrogenase|appos|END_ENTITY	Characterization of a Saccharomyces_cerevisiae NADP -LRB- H -RRB- - dependent alcohol dehydrogenase -LRB- ADHVII -RRB- , a member of the cinnamyl_alcohol dehydrogenase family .
20833657	0	alcohol	42,49	ALDH2	149,154	alcohol	ALDH2	CHEBI:16236	217	Chemical	Gene	consumption|compound|START_ENTITY effects|nmod|consumption interaction|nmod|effects interaction|nmod|individuals individuals|nmod|alleles alleles|compound|END_ENTITY	Strong interaction between the effects of alcohol consumption and smoking on oesophageal_squamous_cell_carcinoma among individuals with ADH1B and/or ALDH2 risk alleles .
22563891	0	alcohol	93,100	ALDH2	71,76	alcohol	ALDH2	CHEBI:16236	217	Chemical	Gene	polymorphism|nmod|START_ENTITY polymorphism|compound|END_ENTITY	Developmental trajectory and environmental moderation of the effect of ALDH2 polymorphism on alcohol use .
26825972	0	alcohol	102,109	ALDH2	80,85	alcohol	ALDH2	D000431	217	Chemical	Gene	sensitivity|compound|START_ENTITY genotypes|nmod|sensitivity genotypes|nsubj|Relationships Relationships|nmod|alcohol_dehydrogenase_1B alcohol_dehydrogenase_1B|appos|END_ENTITY	Relationships of alcohol_dehydrogenase_1B -LRB- ADH1B -RRB- and aldehyde_dehydrogenase_2 -LRB- ALDH2 -RRB- genotypes with alcohol sensitivity , drinking behavior and problem drinking in Japanese older men .
10358022	0	alcohol	26,33	Adh3	54,58	alcohol	Adh3	CHEBI:16236	11529(Tax:10090)	Chemical	Gene	Metabolic_deficiencies|nmod|START_ENTITY dehydrogenase|nsubj|Metabolic_deficiencies dehydrogenase|dobj|END_ENTITY	Metabolic_deficiencies in alcohol dehydrogenase Adh1 , Adh3 , and Adh4 null mutant mice .
1670041	0	alcohol	50,57	Albumin_and_procollagen_type_I	0,30	alcohol	Albumin and procollagen type I	CHEBI:16236	213	Chemical	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	Albumin_and_procollagen_type_I gene regulation in alcohol and viral-induced human liver_disease .
17343998	0	alcohol	113,120	Alcohol_dehydrogenase	0,21	alcohol	Alcohol dehydrogenase	CHEBI:16236	10327	Chemical	Gene	metabolism|compound|START_ENTITY influence|nmod|metabolism content|dep|influence content|amod|END_ENTITY	Alcohol_dehydrogenase and catalase content in perinatal infant and adult livers : potential influence on neonatal alcohol metabolism .
17454860	0	alcohol	70,77	Alcohol_dehydrogenase	0,21	alcohol	Alcohol dehydrogenase	CHEBI:16236	10327	Chemical	Gene	liver_cirrhosis|compound|START_ENTITY END_ENTITY|nmod|liver_cirrhosis	Alcohol_dehydrogenase and aldehyde dehydrogenase gene polymorphism in alcohol liver_cirrhosis and alcohol chronic pancreatitis among Polish individuals .
23149980	0	alcohol	69,76	Alcohol_dehydrogenase	0,21	alcohol	Alcohol dehydrogenase	CHEBI:16236	10327	Chemical	Gene	intake|compound|START_ENTITY polymorphisms|appos|intake polymorphisms|amod|END_ENTITY	Alcohol_dehydrogenase and aldehyde dehydrogenase gene polymorphisms , alcohol intake and the risk of colorectal_cancer in the European Prospective Investigation into Cancer and Nutrition study .
26142864	0	alcohol	101,108	Alcohol_dehydrogenase	0,21	alcohol	Alcohol dehydrogenase	D000431	10327	Chemical	Gene	uptake|compound|START_ENTITY cheese|nmod|uptake Application|nmod|cheese activity|dep|Application activity|amod|END_ENTITY	Alcohol_dehydrogenase activity in Lactococcus chungangensis : Application in cream cheese to moderate alcohol uptake .
3355668	0	alcohol	52,59	Alcohol_dehydrogenase	0,21	alcohol	Alcohol dehydrogenase	CHEBI:16236	58810(Tax:10090)	Chemical	Gene	preference|compound|START_ENTITY determinant|nmod|preference determinant|nsubj|END_ENTITY	Alcohol_dehydrogenase is not a major determinant of alcohol preference in mice .
21848960	0	alcohol	92,99	Brain-derived_neurotrophic_factor	0,33	alcohol	Brain-derived neurotrophic factor	CHEBI:16236	627	Chemical	Gene	withdrawal|compound|START_ENTITY subjects|nmod|withdrawal subjects|nsubj|levels levels|amod|END_ENTITY	Brain-derived_neurotrophic_factor serum levels in alcohol-dependent subjects 6 months after alcohol withdrawal .
23414063	0	alcohol	62,69	Brain-derived_neurotrophic_factor	0,33	alcohol	Brain-derived neurotrophic factor	CHEBI:16236	24225(Tax:10116)	Chemical	Gene	self-administration|compound|START_ENTITY suppression|nmod|self-administration mediates|dobj|suppression mediates|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor mediates the suppression of alcohol self-administration by memantine .
7920048	1	alcohol	65,72	CAGE	44,48	alcohol	CAGE	CHEBI:16236	168400	Chemical	Gene	consumption|compound|START_ENTITY END_ENTITY|nmod|consumption	Using the CAGE and measures of alcohol consumption in family practice .
12770700	0	alcohol	12,19	CB1	56,59	alcohol	CB1	CHEBI:16236	12801(Tax:10090)	Chemical	Gene	decrease|compound|START_ENTITY decrease|nmod|receptor receptor|compound|END_ENTITY	Overeating , alcohol and sucrose consumption decrease in CB1 receptor deleted mice .
15363985	0	alcohol	77,84	CB1	38,41	alcohol	CB1	CHEBI:16236	25248(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|antagonist antagonist|compound|END_ENTITY	Suppressing effect of the cannabinoid CB1 receptor antagonist , SR_141716 , on alcohol 's motivational properties in alcohol-preferring rats .
15466898	0	alcohol	81,88	CB1	11,14	alcohol	CB1	CHEBI:16236	25248(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY cannabinoid|nmod|administration cannabinoid|nsubj|Effects Effects|nmod|END_ENTITY	Effects of CB1 cannabinoid receptor blockade on ethanol preference after chronic alcohol administration combined with repeated re-exposures and withdrawals .
15582988	0	alcohol	122,129	CB1	38,41	alcohol	CB1	CHEBI:16236	25248(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|receptor receptor|compound|END_ENTITY	Suppressing effect of the cannabinoid CB1 receptor antagonist , SR147778 , on alcohol intake and motivational properties of alcohol in alcohol-preferring sP rats .
15582988	0	alcohol	76,83	CB1	38,41	alcohol	CB1	CHEBI:16236	25248(Tax:10116)	Chemical	Gene	intake|compound|START_ENTITY effect|nmod|intake effect|nmod|receptor receptor|compound|END_ENTITY	Suppressing effect of the cannabinoid CB1 receptor antagonist , SR147778 , on alcohol intake and motivational properties of alcohol in alcohol-preferring sP rats .
16216824	0	alcohol	89,96	CB1	32,35	alcohol	CB1	CHEBI:16236	12801(Tax:10090)	Chemical	Gene	alters|nmod|START_ENTITY alters|nsubj|manipulation manipulation|nmod|function function|compound|END_ENTITY	Pharmacological manipulation of CB1 receptor function alters development of tolerance to alcohol .
17067804	0	alcohol	104,111	CB1	4,7	alcohol	CB1	CHEBI:16236	25248(Tax:10116)	Chemical	Gene	prevents|nmod|START_ENTITY prevents|nsubj|rimonabant rimonabant|compound|END_ENTITY	The CB1 cannabinoid receptor antagonist rimonabant chronically prevents the nicotine-induced relapse to alcohol .
18554293	0	alcohol	103,110	CB1	30,33	alcohol	CB1	CHEBI:16236	25248(Tax:10116)	Chemical	Gene	relapse|compound|START_ENTITY increase|nmod|relapse CB1|nmod|increase role|nmod|CB1 activation|dep|role activation|nmod|receptors receptors|compound|END_ENTITY	Pharmacological activation of CB1 and D2 receptors in rats : predominant role of CB1 in the increase of alcohol relapse .
18554293	0	alcohol	103,110	CB1	80,83	alcohol	CB1	CHEBI:16236	25248(Tax:10116)	Chemical	Gene	relapse|compound|START_ENTITY increase|nmod|relapse END_ENTITY|nmod|increase	Pharmacological activation of CB1 and D2 receptors in rats : predominant role of CB1 in the increase of alcohol relapse .
23023167	0	alcohol	115,122	CB1	45,48	alcohol	CB1	CHEBI:16236	12801(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Estrogen-related receptor y controls hepatic CB1 receptor-mediated CYP2E1 expression and oxidative liver_injury by alcohol .
23345080	0	alcohol	160,167	CB1	72,75	alcohol	CB1	CHEBI:16236	12801(Tax:10090)	Chemical	Gene	consumption|compound|START_ENTITY effects|nmod|consumption hippocampus|dep|effects transcript|nmod|hippocampus transcript|compound|END_ENTITY	A spontaneous deletion of a-synuclein is associated with an increase in CB1 mRNA transcript and receptor expression in the hippocampus and amygdala : effects on alcohol consumption .
26786379	0	alcohol	8,15	CB1	34,37	alcohol	CB1	D000431	25248(Tax:10116)	Chemical	Gene	exposure|compound|START_ENTITY disrupts|nsubj|exposure disrupts|dobj|regulation regulation|nummod|END_ENTITY	Chronic alcohol exposure disrupts CB1 regulation of GABAergic transmission in the rat basolateral amygdala .
26800788	0	alcohol	78,85	CB1	12,15	alcohol	CB1	D000431	12801(Tax:10090)	Chemical	Gene	blunts|dobj|START_ENTITY blunts|nsubj|inhibition inhibition|compound|END_ENTITY	Cannabinoid CB1 receptor inhibition blunts adolescent-typical increased binge alcohol and sucrose consumption in male C57BL/6J mice .
7224914	0	alcohol	36,43	CSF	0,3	alcohol	CSF	CHEBI:16236	1437	Chemical	Gene	withdrawal|compound|START_ENTITY levels|nmod|withdrawal levels|compound|END_ENTITY	CSF levels of norepinephrine during alcohol withdrawal .
11530830	0	alcohol	15,22	CYP2E1	47,53	alcohol	CYP2E1	CHEBI:16236	1571	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activity activity|nummod|END_ENTITY	The effects of alcohol and diallyl_sulphide on CYP2E1 activity in humans : a phenotyping study using chlorzoxazone .
12563175	0	alcohol	8,15	CYP2E1	45,51	alcohol	CYP2E1	CHEBI:16236	1571	Chemical	Gene	polymorphisms|compound|START_ENTITY Role|nmod|polymorphisms Role|nmod|END_ENTITY	Role of alcohol and genetic polymorphisms of CYP2E1 and ALDH2 in breast_cancer development .
12777962	0	alcohol	52,59	CYP2E1	0,6	alcohol	CYP2E1	CHEBI:16236	1571	Chemical	Gene	dependence|compound|START_ENTITY association|nmod|dependence *|dep|association *|compound|END_ENTITY	CYP2E1 * 1D regulatory polymorphism : association with alcohol and nicotine dependence .
15841467	0	alcohol	61,68	CYP2E1	12,18	alcohol	CYP2E1	CHEBI:16236	1571	Chemical	Gene	consumption|compound|START_ENTITY adults|nmod|consumption enzymes|nmod|adults enzymes|compound|END_ENTITY	Activity of CYP2E1 and CYP3A enzymes in adults with moderate alcohol consumption : a comparison with nonalcoholics .
18078827	0	alcohol	37,44	CYP2E1	0,6	alcohol	CYP2E1	CHEBI:16236	13106(Tax:10090)	Chemical	Gene	liver_injury|nmod|START_ENTITY liver_injury|nsubj|END_ENTITY	CYP2E1 and oxidative liver_injury by alcohol .
19860798	0	alcohol	17,24	CYP2E1	106,112	alcohol	CYP2E1	CHEBI:16236	1571	Chemical	Gene	enzymes|compound|START_ENTITY Polymorphisms|nmod|enzymes Polymorphisms|dep|frequency frequency|nmod|END_ENTITY	Polymorphisms of alcohol metabolizing enzymes in indigenous Mexican population : unusual high frequency of CYP2E1 * c2 allele .
20958328	0	alcohol	70,77	CYP2E1	23,29	alcohol	CYP2E1	CHEBI:16236	1571	Chemical	Gene	level|nmod|START_ENTITY investigation|nmod|level investigation|nmod|END_ENTITY	The investigation into CYP2E1 in relation to the level of response to alcohol through a combination of linkage and association analysis .
21833537	0	alcohol	8,15	CYP2E1	71,77	alcohol	CYP2E1	CHEBI:16236	415128(Tax:9615)	Chemical	Gene	stress|compound|START_ENTITY stress|dep|role role|nmod|END_ENTITY	Chronic alcohol intake-induced oxidative stress and apoptosis : role of CYP2E1 and calpain-1 in alcoholic_cardiomyopathy .
22940046	4	alcohol	624,631	CYP2E1	598,604	alcohol	CYP2E1	CHEBI:16236	1571	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Cytochrome_P450_2E1 -LRB- CYP2E1 -RRB- plays a critical role in ROS generation and CYP2E1 is also induced by alcohol itself .
22967841	0	alcohol	40,47	CYP2E1	14,20	alcohol	CYP2E1	CHEBI:16236	13106(Tax:10090)	Chemical	Gene	attenuates|iobj|START_ENTITY attenuates|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of CYP2E1 attenuates chronic alcohol intake-induced myocardial contractile_dysfunction and apoptosis .
23023167	0	alcohol	115,122	CYP2E1	67,73	alcohol	CYP2E1	CHEBI:16236	13106(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Estrogen-related receptor y controls hepatic CB1 receptor-mediated CYP2E1 expression and oxidative liver_injury by alcohol .
23352969	0	alcohol	116,123	CYP2E1	14,20	alcohol	CYP2E1	CHEBI:16236	1571	Chemical	Gene	exposure|compound|START_ENTITY cells|nmod|exposure formation|nmod|cells leads|nmod|formation leads|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of CYP2E1 leads to decreased malondialdehyde-acetaldehyde adduct formation in VL-17A cells under chronic alcohol exposure .
23400924	0	alcohol	22,29	CYP2E1	12,18	alcohol	CYP2E1	CHEBI:16236	1571	Chemical	Gene	metabolism|compound|START_ENTITY role|nmod|metabolism role|nmod|END_ENTITY	The role of CYP2E1 in alcohol metabolism and sensitivity in the central nervous system .
26497211	0	alcohol	83,90	CYP2E1	29,35	alcohol	CYP2E1	D000431	1571	Chemical	Gene	accumulation|compound|START_ENTITY effects|nmod|accumulation mediator|nmod|effects END_ENTITY|nmod|mediator	Identification of cytochrome CYP2E1 as critical mediator of synergistic effects of alcohol and cellular lipid accumulation in hepatocytes in vitro .
7601153	0	alcohol	101,108	CYP2E1	14,20	alcohol	CYP2E1	CHEBI:16236	25086(Tax:10116)	Chemical	Gene	infusions|compound|START_ENTITY abolish|nmod|infusions abolish|nsubj|Inhibition Inhibition|nmod|activity activity|compound|END_ENTITY	Inhibition of CYP2E1 activity does not abolish pulsatile urine alcohol concentrations during chronic alcohol infusions .
7601153	0	alcohol	63,70	CYP2E1	14,20	alcohol	CYP2E1	CHEBI:16236	25086(Tax:10116)	Chemical	Gene	concentrations|compound|START_ENTITY abolish|dobj|concentrations abolish|nsubj|Inhibition Inhibition|nmod|activity activity|compound|END_ENTITY	Inhibition of CYP2E1 activity does not abolish pulsatile urine alcohol concentrations during chronic alcohol infusions .
9187260	0	alcohol	106,113	CYP2E1	139,145	alcohol	CYP2E1	CHEBI:16236	25086(Tax:10116)	Chemical	Gene	chronically|nmod|START_ENTITY treated|xcomp|chronically treated|nmod|induction induction|nmod|END_ENTITY	Gadolinium_chloride blocks alcohol-dependent liver_toxicity in rats treated chronically with intragastric alcohol despite the induction of CYP2E1 .
9731720	0	alcohol	141,148	CYP2E1	25,31	alcohol	CYP2E1	CHEBI:16236	1571	Chemical	Gene	genotype|compound|START_ENTITY effect|nmod|genotype polymorphism|dep|effect polymorphism|nmod|END_ENTITY	The RsaI polymorphism of CYP2E1 and susceptibility to alcoholic liver_disease in Caucasians : effect on age of presentation and dependence on alcohol dehydrogenase genotype .
12464405	0	alcohol	54,61	Catalase	0,8	alcohol	Catalase	CHEBI:16236	847	Chemical	Gene	induced|nmod|START_ENTITY elevation|acl|induced prevents|dobj|elevation prevents|nsubj|END_ENTITY	Catalase prevents elevation of -LSB- Ca -LRB- 2 + -RRB- -RSB- -LRB- i -RRB- induced by alcohol in cultured canine cerebral vascular smooth muscle cells : Possible relationship to alcohol-induced stroke and brain pathology .
20575789	0	alcohol	52,59	Catalase	0,8	alcohol	Catalase	CHEBI:16236	847	Chemical	Gene	ingest|dobj|START_ENTITY propensity|acl|ingest regulator|nmod|propensity END_ENTITY|nmod|regulator	Catalase as a regulator of the propensity to ingest alcohol in genetically determined acatalasemic individuals from Israel .
21106310	0	alcohol	37,44	DRD2	0,4	alcohol	DRD2	CHEBI:16236	1813	Chemical	Gene	relation|nmod|START_ENTITY END_ENTITY|nmod|relation	DRD2 and DRD4 in relation to regular alcohol and cannabis use among adolescents : does parenting modify the impact of genetic vulnerability ?
23685324	0	alcohol	87,94	DRD2	20,24	alcohol	DRD2	CHEBI:16236	1813	Chemical	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association between DRD2 , 5-HTTLPR , and ALDH2 genes and specific personality traits in alcohol - and opiate-dependent patients .
10466734	0	alcohol	65,72	Dopamine_transporter	0,20	alcohol	Dopamine transporter	CHEBI:16236	6531	Chemical	Gene	withdrawal|compound|START_ENTITY END_ENTITY|nmod|withdrawal	Dopamine_transporter availability and depressive_symptoms during alcohol withdrawal .
24653683	0	alcohol	88,95	ERK	48,51	alcohol	ERK	CHEBI:16236	5594	Chemical	Gene	activity|nmod|START_ENTITY activity|appos|END_ENTITY	Neuronal extracellular_signal-regulated_kinase -LRB- ERK -RRB- activity as marker and mediator of alcohol and opioid_dependence .
21182554	0	alcohol	76,83	FTO	48,51	alcohol	FTO	CHEBI:16236	79068	Chemical	Gene	consumption|compound|START_ENTITY END_ENTITY|nmod|consumption	Inverse association of the obesity predisposing FTO rs9939609 genotype with alcohol consumption and risk for alcohol_dependence .
20626732	0	alcohol	54,61	FosB	36,40	alcohol	FosB	CHEBI:16236	100360880	Chemical	Gene	intake|compound|START_ENTITY END_ENTITY|nmod|intake	Region-specific induction of FosB / / \ FosB by voluntary alcohol intake : effects of naltrexone .
15702134	0	alcohol	50,57	GABRA2	0,6	alcohol	GABRA2	CHEBI:16236	2555	Chemical	Gene	effects|nmod|START_ENTITY moderate|dobj|effects moderate|nsubj|alleles alleles|compound|END_ENTITY	GABRA2 alleles moderate the subjective effects of alcohol , which are attenuated by finasteride .
18361719	0	alcohol	90,97	GABRA2	11,17	alcohol	GABRA2	CHEBI:16236	2555	Chemical	Gene	responses|nmod|START_ENTITY variation|nmod|responses variation|nummod|END_ENTITY	Effects of GABRA2 variation on physiological , psychomotor and subjective responses in the alcohol challenge twin study .
19672139	0	alcohol	27,34	GABRA2	8,14	alcohol	GABRA2	CHEBI:16236	2555	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of GABRA2 on risk for alcohol , nicotine , and cannabis_dependence in the Iowa Adoption Studies .
19833324	0	alcohol	68,75	GABRA2	17,23	alcohol	GABRA2	CHEBI:16236	2555	Chemical	Gene	influence|nmod|START_ENTITY influence|nmod|END_ENTITY	The influence of GABRA2 , childhood trauma , and their interaction on alcohol , heroin , and cocaine_dependence .
20698837	0	alcohol	75,82	GABRA2	18,24	alcohol	GABRA2	CHEBI:16236	2555	Chemical	Gene	cues|compound|START_ENTITY associated|nmod|cues associated|nsubjpass|polymorphism polymorphism|nmod|END_ENTITY	A polymorphism in GABRA2 is associated with the medial frontal response to alcohol cues in an fMRI study .
21118274	0	alcohol	53,60	GABRA2	8,14	alcohol	GABRA2	CHEBI:16236	2555	Chemical	Gene	moderating|nmod|START_ENTITY END_ENTITY|acl|moderating	Role of GABRA2 in moderating subjective responses to alcohol .
22501025	0	alcohol	50,57	GABRA2	0,6	alcohol	GABRA2	CHEBI:16236	2555	Chemical	Gene	effects|nmod|START_ENTITY moderate|dobj|effects moderate|nsubj|markers markers|compound|END_ENTITY	GABRA2 markers moderate the subjective effects of alcohol .
23692184	0	alcohol	22,29	GABRA2	64,70	alcohol	GABRA2	CHEBI:16236	2555	Chemical	Gene	use|compound|START_ENTITY influences|nmod|use influences|dep|trajectories trajectories|compound|END_ENTITY	Genetic influences on alcohol use across stages of development : GABRA2 and longitudinal trajectories of drunkenness from adolescence to young adulthood .
6118071	0	alcohol	145,152	Gamma-glutamyl_transpeptidase	0,29	alcohol	Gamma-glutamyl transpeptidase	CHEBI:16236	92086	Chemical	Gene	consumption|compound|START_ENTITY predicting|dobj|consumption index|acl|predicting advantages|nmod|index cholesterol|dep|advantages cholesterol|compound|END_ENTITY	Gamma-glutamyl_transpeptidase and high-density lipoproteins cholesterol in male problem drinkers : advantages of a composite index for predicting alcohol consumption .
26051400	0	alcohol	19,26	GluN2A	55,61	alcohol	GluN2A	D000431	2903	Chemical	Gene	action|compound|START_ENTITY action|nmod|END_ENTITY	Different sites of alcohol action in the NMDA receptor GluN2A and GluN2B subunits .
10421807	0	alcohol	11,18	GnRH	42,46	alcohol	GnRH	CHEBI:16236	2796	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|system system|compound|END_ENTITY	Effects of alcohol on the human placental GnRH receptor system .
999327	0	alcohol	33,40	Growth_hormone	0,14	alcohol	Growth hormone	CHEBI:16236	2688	Chemical	Gene	syndrome|compound|START_ENTITY END_ENTITY|nmod|syndrome	Growth_hormone response in fetal alcohol syndrome .
16888021	0	alcohol	65,72	Heme_oxygenase-1	0,16	alcohol	Heme oxygenase-1	CHEBI:16236	15368(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY mediates|dobj|effects mediates|nsubj|END_ENTITY	Heme_oxygenase-1 mediates the anti-inflammatory effects of acute alcohol on IL-10 induction involving p38_MAPK activation in monocytes .
1789378	0	alcohol	6,13	LHRH	38,42	alcohol	LHRH	CHEBI:16236	25194(Tax:10116)	Chemical	Gene	exposure|compound|START_ENTITY exposure|nmod|END_ENTITY	Fetal alcohol exposure and effects of LHRH and PMA on LH_beta-mRNA expression in the female rat .
17239487	0	alcohol	24,31	Neuropeptide_Y	0,14	alcohol	Neuropeptide Y	CHEBI:16236	24604(Tax:10116)	Chemical	Gene	intake|compound|START_ENTITY END_ENTITY|nmod|intake	Neuropeptide_Y -LRB- NPY -RRB- in alcohol intake and dependence .
1057100	0	alcohol	50,57	Part_1	36,42	alcohol	Part 1	CHEBI:16236	25859	Chemical	Gene	analysis|compound|START_ENTITY END_ENTITY|appos|analysis	Christchurch traffic trauma survey : Part_1 , Blood alcohol analysis .
17346019	0	alcohol	25,32	Part_1	0,6	alcohol	Part 1	CHEBI:16236	25859	Chemical	Gene	guide|acl|START_ENTITY END_ENTITY|dep|guide	Part_1 : nurses ' guide to alcohol and promoting healthy lifestyle changes .
20729530	0	alcohol	78,85	Part_1	50,56	alcohol	Part 1	CHEBI:16236	25859	Chemical	Gene	polydrug|compound|START_ENTITY cues|compound|polydrug BOLD|nmod|cues BOLD|dobj|response response|appos|END_ENTITY	fMRI BOLD response in high-risk college students -LRB- Part_1 -RRB- : during exposure to alcohol , marijuana , polydrug and emotional picture cues .
22970527	1	alcohol	81,88	Part_1	36,42	alcohol	Part 1	CHEBI:16236	25859	Chemical	Gene	-RSB-|compound|START_ENTITY effects|nmod|-RSB- END_ENTITY|dep|effects	Part_1 : metabolism and pathogenic effects of alcohol -RSB- .
7904114	1	alcohol	125,132	Part_1	81,87	alcohol	Part 1	CHEBI:16236	25859	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|dep|Effect	-LRB- Part_1 -RRB- : Effect of obesity and ingestion of alcohol on gamma-GTP level in serum -RSB- .
1797033	0	alcohol	46,53	Prolactin	0,9	alcohol	Prolactin	CHEBI:16236	5617	Chemical	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	Prolactin and cortisol levels following acute alcohol challenges in women with and without a family history of alcoholism .
21121933	0	alcohol	30,37	Prolactin	0,9	alcohol	Prolactin	CHEBI:16236	5617	Chemical	Gene	withdrawal|compound|START_ENTITY levels|nmod|withdrawal levels|amod|END_ENTITY	Prolactin serum levels during alcohol withdrawal are associated with the severity of alcohol_dependence and withdrawal_symptoms .
7623621	0	alcohol	56,63	Prolactin	0,9	alcohol	Prolactin	CHEBI:16236	24683(Tax:10116)	Chemical	Gene	exposure|compound|START_ENTITY rats|nmod|exposure lactating|dobj|rats secretion|acl|lactating secretion|compound|END_ENTITY	Prolactin secretion in lactating rats following chronic alcohol exposure : provocative tests with secretagogues .
14615008	0	alcohol	105,112	Proliferating_cell_nuclear_antigen	0,34	alcohol	Proliferating cell nuclear antigen	CHEBI:16236	18538(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Proliferating_cell_nuclear_antigen expression on tongue of mice after intake of , or topical exposure to , alcohol .
15885048	0	alcohol	17,24	S-100B	41,47	alcohol	S-100B	D000431	6285	Chemical	Gene	influence|nmod|START_ENTITY influence|nmod|levels levels|compound|END_ENTITY	The influence of alcohol and time on the S-100B levels of patients with minor head_injury .
24570955	0	alcohol	56,63	SIRT1	105,110	alcohol	SIRT1	CHEBI:16236	309757(Tax:10116)	Chemical	Gene	consumption|compound|START_ENTITY nonalcoholic_steatohepatitis|nmod|consumption Aggravation|nmod|nonalcoholic_steatohepatitis associated|nsubjpass|Aggravation associated|nmod|activity activity|compound|END_ENTITY	Aggravation of nonalcoholic_steatohepatitis by moderate alcohol consumption is associated with decreased SIRT1 activity in rats .
17575268	0	alcohol	6,13	STAT3	24,29	alcohol	STAT3	CHEBI:16236	6774	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Acute alcohol activates STAT3 , AP-1 , and Sp-1 transcription factors via the family of Src kinases to promote IL-10 production in human monocytes .
23064763	0	alcohol	65,72	STAT3	114,119	alcohol	STAT3	CHEBI:16236	25125(Tax:10116)	Chemical	Gene	exposure|compound|START_ENTITY induced|nmod|exposure induced|ccomp|impair impair|dobj|translocation translocation|nmod|END_ENTITY	Hepatic microtubule acetylation and stability induced by chronic alcohol exposure impair nuclear translocation of STAT3 and STAT5B , but not Smad2/3 .
9438522	0	alcohol	118,125	TA-0910	107,114	alcohol	TA-0910	CHEBI:16236	1456445(Tax:273075)	Chemical	Gene	intake|compound|START_ENTITY END_ENTITY|nmod|intake	Involvement of dopamine D2 receptors in the suppressive effect of the thyrotropin-releasing_hormone analog TA-0910 on alcohol intake in alcohol-preferring rats .
20036843	0	alcohol	22,29	TGF-beta	0,8	alcohol	TGF-beta	CHEBI:16236	7040	Chemical	Gene	signaling|nmod|START_ENTITY signaling|amod|END_ENTITY	TGF-beta signaling in alcohol induced hepatic_injury .
12626543	0	alcohol	6,13	TNF-alpha	23,32	alcohol	TNF-alpha	CHEBI:16236	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|processing processing|amod|END_ENTITY	Acute alcohol inhibits TNF-alpha processing in human monocytes by inhibiting TNF/TNF-alpha-converting _ enzyme interactions in the cell membrane .
1320807	0	alcohol	16,23	TNF-alpha	42,51	alcohol	TNF-alpha	CHEBI:16236	7124	Chemical	Gene	administration|compound|START_ENTITY Effect|nmod|administration Effect|nmod|membranes membranes|amod|END_ENTITY	Effect of acute alcohol administration on TNF-alpha binding to neutrophils and isolated liver plasma membranes .
18312327	0	alcohol	146,153	TNF-alpha	24,33	alcohol	TNF-alpha	CHEBI:16236	7124	Chemical	Gene	consumption|compound|START_ENTITY converting|nmod|consumption alpha|xcomp|converting alpha|nsubj|factor factor|appos|END_ENTITY	Tumour_necrosis factor -LRB- TNF-alpha -RRB- alpha converting enzyme and soluble TNF-alpha receptor type 1 in psoriasis patients in relation to the chronic alcohol consumption .
18312327	0	alcohol	146,153	TNF-alpha	71,80	alcohol	TNF-alpha	CHEBI:16236	7124	Chemical	Gene	consumption|compound|START_ENTITY converting|nmod|consumption converting|dobj|receptor receptor|amod|END_ENTITY	Tumour_necrosis factor -LRB- TNF-alpha -RRB- alpha converting enzyme and soluble TNF-alpha receptor type 1 in psoriasis patients in relation to the chronic alcohol consumption .
18579335	0	alcohol	38,45	TNF-alpha	6,15	alcohol	TNF-alpha	CHEBI:16236	7124	Chemical	Gene	consumption|compound|START_ENTITY Serum|nmod|consumption Serum|dobj|levels levels|amod|END_ENTITY	Serum TNF-alpha levels in relation to alcohol consumption and common TNF gene polymorphisms .
9590519	0	alcohol	20,27	TNF-alpha	88,97	alcohol	TNF-alpha	CHEBI:16236	24835(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of prenatal alcohol and pair feeding on lipopolysaccharide-induced secretion of TNF-alpha and corticosterone .
238067	0	alcohol	11,18	Task	42,46	alcohol	Task	CHEBI:16236	3777	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of alcohol on a Critical Tracking Task .
24215387	0	alcohol	84,91	Task	54,58	alcohol	Task	CHEBI:16236	3777	Chemical	Gene	result|nmod|START_ENTITY making|nmod|result making|nmod|END_ENTITY	Impaired decision making on the Balloon Analogue Risk Task as a result of long-term alcohol use .
7625565	0	alcohol	122,129	Tumor_necrosis_factor-alpha	0,27	alcohol	Tumor necrosis factor-alpha	CHEBI:16236	24835(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY cells|nmod|administration parenchymal|dobj|cells parenchymal|nsubj|receptors receptors|amod|END_ENTITY	Tumor_necrosis_factor-alpha cell-surface receptors of liver parenchymal and nonparenchymal cells during acute and chronic alcohol administration to rats .
10653746	0	alcohol	26,33	acetyltransferase	34,51	alcohol	acetyltransferase	CHEBI:16236	853237(Tax:4932)	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of increased yeast alcohol acetyltransferase activity on flavor profiles of wine and distillates .
12937998	0	alcohol	56,63	acetyltransferase	64,81	alcohol	acetyltransferase	CHEBI:16236	853237(Tax:4932)	Chemical	Gene	expression|nmod|START_ENTITY END_ENTITY|nsubj|expression	Heterologous expression of the Saccharomyces_cerevisiae alcohol acetyltransferase genes in Clostridium_acetobutylicum and Escherichia_coli for the production of isoamyl_acetate .
16233768	0	alcohol	118,125	acetyltransferase	126,143	alcohol	acetyltransferase	CHEBI:16236	853237(Tax:4932)	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Improved production of isoamyl_acetate by a sake yeast mutant resistant to an isoprenoid analog and its dependence on alcohol acetyltransferase activity , but not on isoamyl_alcohol production .
16845703	0	alcohol	30,37	acetyltransferase	38,55	alcohol	acetyltransferase	CHEBI:16236	853237(Tax:4932)	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nsubj|effect	The effect of increased yeast alcohol acetyltransferase and esterase activity on the flavour profiles of wine and distillates .
11202400	0	alcohol	57,64	alcohol_dehydrogenase	19,40	alcohol	alcohol dehydrogenase	CHEBI:16236	10327	Chemical	Gene	-RSB-|compound|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- The role of blood alcohol_dehydrogenase in pathological alcohol involvement -RSB- .
11525126	0	alcohol	30,37	alcohol_dehydrogenase	91,112	alcohol	alcohol dehydrogenase	CHEBI:16236	78959(Tax:10116)	Chemical	Gene	motivation|compound|START_ENTITY motivation|nmod|immunization immunization|nmod|rats rats|nmod|I I|amod|END_ENTITY	-LSB- Mechanisms of suppression of alcohol motivation after immunization of albino rats against alcohol_dehydrogenase I : The role of ADH epitopes and ADH activity in the adrenal glands -RSB- .
12652939	0	alcohol	81,88	alcohol_dehydrogenase	155,176	alcohol	alcohol dehydrogenase	CHEBI:16236	78959(Tax:10116)	Chemical	Gene	motivation|compound|START_ENTITY decreases|dobj|motivation decreases|advcl|elevating elevating|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Administration of the omega-3_polyunsaturated_fatty_acid drug eiferol decreases alcohol motivation in albino rats by elevating the level of antibodies to alcohol_dehydrogenase -RSB- .
1543513	0	alcohol	53,60	alcohol_dehydrogenase	6,27	alcohol	alcohol dehydrogenase	CHEBI:16236	10327	Chemical	Gene	oxidation|compound|START_ENTITY dependence|nmod|oxidation END_ENTITY|dep|dependence	Human alcohol_dehydrogenase : dependence of secondary alcohol oxidation on the amino_acids at positions 93 and 94 .
1751766	0	alcohol	68,75	alcohol_dehydrogenase	43,64	alcohol	alcohol dehydrogenase	CHEBI:16236	78959(Tax:10116)	Chemical	Gene	consumption|compound|START_ENTITY END_ENTITY|nmod|consumption	Influence of native and modified exogenous alcohol_dehydrogenase on alcohol consumption in rats .
17718394	0	alcohol	16,23	alcohol_dehydrogenase	44,65	alcohol	alcohol dehydrogenase	CHEBI:16236	10327	Chemical	Gene	metabolism|compound|START_ENTITY genetics|nmod|metabolism genetics|dep|role role|nmod|variants variants|amod|END_ENTITY	The genetics of alcohol metabolism : role of alcohol_dehydrogenase and aldehyde_dehydrogenase variants .
18585217	0	alcohol	194,201	alcohol_dehydrogenase	168,189	alcohol	alcohol dehydrogenase	CHEBI:16236	10327	Chemical	Gene	sensing|compound|START_ENTITY modified|nmod|sensing modified|dobj|electrode electrode|nmod|END_ENTITY	Electrocatalytic oxidation of NADH at gold nanoparticles loaded poly -LRB- 3,4-ethylenedioxythiophene -RRB- - poly -LRB- styrene_sulfonic_acid -RRB- film modified electrode and integration of alcohol_dehydrogenase for alcohol sensing .
22144473	0	alcohol	107,114	alcohol_dehydrogenase	21,42	alcohol	alcohol dehydrogenase	CHEBI:16236	124	Chemical	Gene	consumption|compound|START_ENTITY cohort|nsubj|consumption cohort|nsubj|variation variation|nmod|END_ENTITY	Genetic variation in alcohol_dehydrogenase -LRB- ADH1A , ADH1B , ADH1C , ADH7 -RRB- and aldehyde_dehydrogenase -LRB- ALDH2 -RRB- , alcohol consumption and gastric_cancer risk in the European Prospective Investigation into Cancer and Nutrition -LRB- EPIC -RRB- cohort .
23915245	0	alcohol	70,77	alcohol_dehydrogenase	31,52	alcohol	alcohol dehydrogenase	CHEBI:16236	10327	Chemical	Gene	rates|compound|START_ENTITY polymorphisms|nmod|rates polymorphisms|nsubj|Evaluation Evaluation|nmod|influence influence|nmod|END_ENTITY	Evaluation of the influence of alcohol_dehydrogenase polymorphisms on alcohol elimination rates in African Americans .
2932115	0	alcohol	55,62	alcohol_dehydrogenase	8,29	alcohol	alcohol dehydrogenase	CHEBI:16236	58810(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY increase|nmod|metabolism Role|nmod|increase Role|nmod|END_ENTITY	Role of alcohol_dehydrogenase in the swift increase in alcohol metabolism -LRB- SIAM -RRB- .
3147212	0	alcohol	129,136	alcohol_dehydrogenase	4,25	alcohol	alcohol dehydrogenase	CHEBI:16236	3771877(Tax:7227)	Chemical	Gene	stress|compound|START_ENTITY conditions|nmod|stress measurements|nmod|conditions polymorphism|dep|measurements polymorphism|amod|END_ENTITY	The alcohol_dehydrogenase polymorphism in Drosophila_melanogaster : fitness measurements and predictions under conditions with no alcohol stress .
627079	0	alcohol	75,82	alcohol_dehydrogenase	16,37	alcohol	alcohol dehydrogenase	CHEBI:16236	10327	Chemical	Gene	assay|nmod|START_ENTITY procedure|nmod|assay procedure|amod|END_ENTITY	Pitfalls of the alcohol_dehydrogenase procedure for the emergency assay of alcohol : a case study of isopropanol overdose .
6347067	0	alcohol	103,110	alcohol_dehydrogenase	54,75	alcohol	alcohol dehydrogenase	CHEBI:16236	78959(Tax:10116)	Chemical	Gene	rates|compound|START_ENTITY predicting|dobj|rates application|acl|predicting properties|dep|application properties|nmod|END_ENTITY	Steady-state kinetic properties of purified rat liver alcohol_dehydrogenase : application to predicting alcohol elimination rates in vivo .
6354997	0	alcohol	73,80	alcohol_dehydrogenase	12,33	alcohol	alcohol dehydrogenase	CHEBI:16236	10327	Chemical	Gene	metabolism|compound|START_ENTITY isozymes|nmod|metabolism isozymes|nsubj|role role|nmod|dehydrogenase dehydrogenase|amod|END_ENTITY	The role of alcohol_dehydrogenase and aldehyde dehydrogenase isozymes in alcohol metabolism , alcohol sensitivity , and alcoholism .
6788040	0	alcohol	24,31	alcohol_dehydrogenase	68,89	alcohol	alcohol dehydrogenase	CHEBI:16236	3771877(Tax:7227)	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of environmental alcohol on in vivo properties of Drosophila alcohol_dehydrogenase .
7695787	0	alcohol	89,96	alcohol_dehydrogenase	30,51	alcohol	alcohol dehydrogenase	CHEBI:16236	10327	Chemical	Gene	consumption|compound|START_ENTITY significance|nmod|consumption polymorphism|dep|significance polymorphism|nmod|END_ENTITY	Genetic polymorphism of liver alcohol_dehydrogenase in Spanish subjects : significance of alcohol consumption and liver_disease .
7945338	0	alcohol	28,35	alcohol_dehydrogenase	65,86	alcohol	alcohol dehydrogenase	CHEBI:16236	10327	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|mediation mediation|nmod|END_ENTITY	Cardioprotective effects of alcohol : mediation by human vascular alcohol_dehydrogenase .
8834233	0	alcohol	78,85	alcohol_dehydrogenase	40,61	alcohol	alcohol dehydrogenase	CHEBI:16236	10327	Chemical	Gene	sensitivity|compound|START_ENTITY subunit|nmod|sensitivity subunit|nsubj|contribution contribution|nmod|polymorphism polymorphism|nmod|beta beta|amod|END_ENTITY	The contribution of polymorphism in the alcohol_dehydrogenase beta subunit to alcohol sensitivity in a Japanese population .
3921727	0	alcohol	23,30	apolipoproteins_A-I_and_A-II	47,75	alcohol	apolipoproteins A-I and A-II	CHEBI:16236	114548	Chemical	Gene	intake|compound|START_ENTITY effect|nmod|intake effect|nmod|END_ENTITY	The effect of moderate alcohol intake on serum apolipoproteins_A-I_and_A-II .
7996481	0	alcohol	69,76	atrial_natriuretic_peptide	17,43	alcohol	atrial natriuretic peptide	CHEBI:16236	24602(Tax:10116)	Chemical	Gene	injection|nmod|START_ENTITY END_ENTITY|nmod|injection	Increased plasma atrial_natriuretic_peptide after acute injection of alcohol in rats .
10776662	0	alcohol	50,57	beta-endorphin	68,82	alcohol	beta-endorphin	CHEBI:16236	5443	Chemical	Gene	responses|nmod|START_ENTITY heritability|nmod|responses Analysis|nmod|heritability Analysis|dep|END_ENTITY	Analysis of heritability of hormonal responses to alcohol in twins : beta-endorphin as a potential biomarker of genetic risk for alcoholism .
11704624	0	alcohol	96,103	beta-endorphin	17,31	alcohol	beta-endorphin	CHEBI:16236	5443	Chemical	Gene	withdrawal|compound|START_ENTITY levels|nmod|withdrawal levels|nmod|END_ENTITY	Plasma levels of beta-endorphin , adrenocorticotropic_hormone and cortisol during early and late alcohol withdrawal .
12188097	0	alcohol	52,59	beta-endorphin	24,38	alcohol	beta-endorphin	CHEBI:16236	5443	Chemical	Gene	challenge|compound|START_ENTITY change|nmod|challenge change|amod|END_ENTITY	Alcohol urge and plasma beta-endorphin change after alcohol challenge with naltrexone pretreatment in social drinkers .
12658106	0	alcohol	143,150	beta-endorphin	111,125	alcohol	beta-endorphin	CHEBI:16236	5443	Chemical	Gene	intake|compound|START_ENTITY function|nmod|intake END_ENTITY|nmod|function	Effect of chronic alcohol consumption on the activity of the hypothalamic-pituitary-adrenal_axis and pituitary beta-endorphin as a function of alcohol intake , age , and gender .
12658106	0	alcohol	18,25	beta-endorphin	111,125	alcohol	beta-endorphin	CHEBI:16236	5443	Chemical	Gene	consumption|compound|START_ENTITY Effect|nmod|consumption Effect|nmod|activity activity|nmod|END_ENTITY	Effect of chronic alcohol consumption on the activity of the hypothalamic-pituitary-adrenal_axis and pituitary beta-endorphin as a function of alcohol intake , age , and gender .
16340453	0	alcohol	70,77	beta-endorphin	40,54	alcohol	beta-endorphin	CHEBI:16236	5443	Chemical	Gene	Differences|nmod|START_ENTITY Differences|nmod|END_ENTITY	Differences in the peripheral levels of beta-endorphin in response to alcohol and stress as a function of alcohol_dependence and family history of alcoholism .
21187108	0	alcohol	66,73	beta-endorphin	41,55	alcohol	beta-endorphin	CHEBI:16236	5443	Chemical	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	Voluntary_alcohol_consumption and plasma beta-endorphin levels in alcohol preferring rats chronically treated with levetiracetam : a preliminary study .
2526916	0	alcohol	98,105	beta-endorphin	22,36	alcohol	beta-endorphin	CHEBI:16236	5443	Chemical	Gene	withdrawal|compound|START_ENTITY management|nmod|withdrawal induced|nmod|management induced|dobj|release release|amod|END_ENTITY	Physostigmine induced beta-endorphin release as a mechanism for physostigmine management of early alcohol withdrawal .
7695050	0	alcohol	130,137	beta-endorphin	45,59	alcohol	beta-endorphin	CHEBI:16236	5443	Chemical	Gene	tolerance|compound|START_ENTITY evidence|nmod|tolerance Effects|dep|evidence Effects|nmod|alcohol alcohol|nmod|secretion secretion|amod|END_ENTITY	Effects of chronic alcohol on immunoreactive beta-endorphin secretion from hypothalamic neurons in primary cultures : evidence for alcohol tolerance , withdrawal , and sensitization responses .
7695050	0	alcohol	19,26	beta-endorphin	45,59	alcohol	beta-endorphin	CHEBI:16236	5443	Chemical	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	Effects of chronic alcohol on immunoreactive beta-endorphin secretion from hypothalamic neurons in primary cultures : evidence for alcohol tolerance , withdrawal , and sensitization responses .
11169630	0	alcohol	11,18	brain-derived_neurotrophic_factor	22,55	alcohol	brain-derived neurotrophic factor	CHEBI:16236	24225(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effects of alcohol on brain-derived_neurotrophic_factor mRNA expression in discrete regions of the rat hippocampus and hypothalamus .
15854584	0	alcohol	20,27	brain-derived_neurotrophic_factor	40,73	alcohol	brain-derived neurotrophic factor	CHEBI:16236	24225(Tax:10116)	Chemical	Gene	exposure|compound|START_ENTITY exposure|nmod|END_ENTITY	Effects of prenatal alcohol exposure on brain-derived_neurotrophic_factor and its receptor tyrosine_kinase_B in offspring .
18326550	0	alcohol	71,78	brain-derived_neurotrophic_factor	21,54	alcohol	brain-derived neurotrophic factor	CHEBI:16236	627	Chemical	Gene	withdrawal|compound|START_ENTITY Alterations|nmod|withdrawal Alterations|nmod|levels levels|compound|END_ENTITY	Alterations of serum brain-derived_neurotrophic_factor levels in early alcohol withdrawal .
18445109	0	alcohol	126,133	brain-derived_neurotrophic_factor	40,73	alcohol	brain-derived neurotrophic factor	CHEBI:16236	24225(Tax:10116)	Chemical	Gene	amygdala|nmod|START_ENTITY preferring|nsubj|amygdala Innate|advcl|preferring Innate|dobj|differences differences|nmod|expression expression|nmod|END_ENTITY	Innate differences in the expression of brain-derived_neurotrophic_factor in the regions within the extended amygdala between alcohol preferring and nonpreferring rats .
18558427	0	alcohol	6,13	brain-derived_neurotrophic_factor	96,129	alcohol	brain-derived neurotrophic factor	CHEBI:16236	12064(Tax:10090)	Chemical	Gene	disorder-associated_depression|compound|START_ENTITY disorder-associated_depression|dep|evidence evidence|nmod|reductions reductions|nmod|levels levels|nmod|END_ENTITY	Fetal alcohol spectrum disorder-associated_depression : evidence for reductions in the levels of brain-derived_neurotrophic_factor in a mouse model .
23128606	0	alcohol	92,99	brain-derived_neurotrophic_factor	6,39	alcohol	brain-derived neurotrophic factor	CHEBI:16236	627	Chemical	Gene	withdrawal|compound|START_ENTITY END_ENTITY|nmod|withdrawal	Serum brain-derived_neurotrophic_factor and nerve_growth_factor concentrations change after alcohol withdrawal : preliminary data of a case-control comparison .
26941165	0	alcohol	56,63	brain-derived_neurotrophic_factor	105,138	alcohol	brain-derived neurotrophic factor	D000431	24225(Tax:10116)	Chemical	Gene	mechanisms|nmod|START_ENTITY role|nmod|mechanisms exposure-induced|nsubj|role exposure-induced|nmod|expression expression|amod|END_ENTITY	A role for histone acetylation mechanisms in adolescent alcohol exposure-induced deficits in hippocampal brain-derived_neurotrophic_factor expression and neurogenesis markers in adulthood .
15763170	0	alcohol	22,29	c-Fos	48,53	alcohol	c-Fos	CHEBI:16236	2353	Chemical	Gene	administration|compound|START_ENTITY administration|nmod|expression expression|amod|END_ENTITY	Influence of maternal alcohol administration on c-Fos expression in the hippocampus of infant rats .
16340450	0	alcohol	6,13	c-Fos	44,49	alcohol	c-Fos	CHEBI:16236	14281(Tax:10090)	Chemical	Gene	withdrawal|compound|START_ENTITY associated|nsubjpass|withdrawal associated|nmod|expression expression|amod|END_ENTITY	Acute alcohol withdrawal is associated with c-Fos expression in the basal ganglia and associated circuitry : C57BL/6J and DBA/2J inbred mouse strain analyses .
22285885	0	alcohol	9,16	c-Fos	107,112	alcohol	c-Fos	CHEBI:16236	314322(Tax:10116)	Chemical	Gene	exposure|compound|START_ENTITY exposure|dep|effects effects|nmod|expression expression|amod|END_ENTITY	Neonatal alcohol exposure and the hippocampus in developing male rats : effects on behaviorally induced CA1 c-Fos expression , CA1 pyramidal cell number , and contextual fear conditioning .
9154216	0	alcohol	113,120	c-Fos	28,33	alcohol	c-Fos	CHEBI:16236	2353	Chemical	Gene	doses|nmod|START_ENTITY sensitivity|nmod|doses sensitivity|nmod|expression expression|amod|END_ENTITY	Differential sensitivity of c-Fos expression in hippocampus and other brain regions to moderate and low doses of alcohol .
9187343	0	alcohol	72,79	c-Fos	16,21	alcohol	c-Fos	CHEBI:16236	314322(Tax:10116)	Chemical	Gene	consumption|compound|START_ENTITY selected|nmod|consumption selected|nsubj|expression expression|amod|END_ENTITY	Ethanol-induced c-Fos expression in rat lines selected for low and high alcohol consumption .
9835277	0	alcohol	9,16	c-Fos	55,60	alcohol	c-Fos	CHEBI:16236	14281(Tax:10090)	Chemical	Gene	administration|compound|START_ENTITY affects|nsubj|administration affects|dobj|immunoreactivity immunoreactivity|amod|END_ENTITY	Repeated alcohol administration differentially affects c-Fos and FosB protein immunoreactivity in DBA/2J mice .
11860963	0	alcohol	15,22	c-fos	26,31	alcohol	c-fos	CHEBI:16236	314322(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY -LSB-|dobj|effect -LSB-|nmod|expression expression|amod|END_ENTITY	-LSB- The effect of alcohol on c-fos gene expression in rat embryo neuroglial -RSB- .
16359808	0	alcohol	155,162	c-fos	58,63	alcohol	c-fos	CHEBI:16236	314322(Tax:10116)	Chemical	Gene	reinstatement|nmod|START_ENTITY Relationship|nmod|reinstatement Effects|dep|Relationship Effects|nmod|stressors stressors|nmod|END_ENTITY	Effects of environmental and pharmacological stressors on c-fos and corticotropin-releasing_factor mRNA in rat brain : Relationship to the reinstatement of alcohol seeking .
18001278	0	alcohol	54,61	c-fos	106,111	alcohol	c-fos	CHEBI:16236	314322(Tax:10116)	Chemical	Gene	renewal|nmod|START_ENTITY blockade|nmod|renewal Effects|nmod|blockade Effects|dep|relationship relationship|nmod|expression expression|amod|END_ENTITY	Effects of opioid receptor blockade on the renewal of alcohol seeking induced by context : relationship to c-fos mRNA expression .
18755245	0	alcohol	91,98	c-fos	40,45	alcohol	c-fos	CHEBI:16236	14281(Tax:10090)	Chemical	Gene	relationship|nmod|START_ENTITY Effects|dep|relationship Effects|nmod|stressors stressors|nmod|END_ENTITY	Effects of pharmacological stressors on c-fos and CRF mRNA in mouse brain : relationship to alcohol seeking .
7839314	0	alcohol	24,31	c-fos	64,69	alcohol	c-fos	CHEBI:16236	314322(Tax:10116)	Chemical	Gene	administration|nmod|START_ENTITY blocks|nsubj|administration blocks|dobj|protein protein|compound|END_ENTITY	Acute administration of alcohol blocks cocaine-induced striatal c-fos immunoreactivity protein in the rat .
12876071	0	alcohol	29,36	c-myc	65,70	alcohol	c-myc	CHEBI:16236	24577(Tax:10116)	Chemical	Gene	exposure|compound|START_ENTITY effects|nmod|exposure effects|nmod|END_ENTITY	Acute and chronic effects of alcohol exposure on skeletal muscle c-myc , p53 , and Bcl-2 mRNA expression .
18969169	0	alcohol	46,53	catalase	17,25	alcohol	catalase	CHEBI:16236	847	Chemical	Gene	determination|compound|START_ENTITY based|nmod|determination based|nsubj|Development Development|nmod|END_ENTITY	Development of a catalase based biosensor for alcohol determination in beer samples .
18969169	1	alcohol	140,147	catalase	120,128	alcohol	catalase	CHEBI:16236	847	Chemical	Gene	determination|compound|START_ENTITY enzyme|nmod|determination enzyme|amod|END_ENTITY	An amperometric biosensor based on catalase enzyme for alcohol determination was developed .
1910297	0	alcohol	31,38	catalase	19,27	alcohol	catalase	CHEBI:16236	40048(Tax:7227)	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	The involvement of catalase in alcohol metabolism in Drosophila_melanogaster larvae .
3160372	0	alcohol	17,24	catalase	46,54	alcohol	catalase	CHEBI:16236	847	Chemical	Gene	dehydrogenase|compound|START_ENTITY roles|nmod|dehydrogenase ethanol|nmod|roles ethanol|nsubj|END_ENTITY	In vivo roles of alcohol dehydrogenase -LRB- ADH -RRB- , catalase and the microsomal ethanol oxidizing system -LRB- MEOS -RRB- in deermice .
3426685	0	alcohol	22,29	catalase	126,134	alcohol	catalase	CHEBI:16236	847	Chemical	Gene	deermice|compound|START_ENTITY metabolism|nmod|deermice mediated|nsubjpass|metabolism mediated|advcl|system system|nmod|END_ENTITY	Ethanol metabolism in alcohol dehydrogenase deficient deermice is mediated by the microsomal ethanol oxidizing system , not by catalase .
4040382	0	alcohol	27,34	catalase	78,86	alcohol	catalase	CHEBI:16236	847	Chemical	Gene	consumption|compound|START_ENTITY model|nmod|consumption model|dep|interaction interaction|nmod|END_ENTITY	A two dimensional model of alcohol consumption : possible interaction of brain catalase and aldehyde dehydrogenase .
8561276	0	alcohol	148,155	catalase	99,107	alcohol	catalase	CHEBI:16236	847	Chemical	Gene	ingest|dobj|START_ENTITY propensity|acl|ingest marker|nmod|propensity END_ENTITY|nmod|marker	Family history of alcoholism and the mediation of alcohol intake by catalase : further evidence for catalase as a marker of the propensity to ingest alcohol .
8561276	0	alcohol	50,57	catalase	68,76	alcohol	catalase	CHEBI:16236	847	Chemical	Gene	intake|compound|START_ENTITY intake|nmod|END_ENTITY	Family history of alcoholism and the mediation of alcohol intake by catalase : further evidence for catalase as a marker of the propensity to ingest alcohol .
9922984	0	alcohol	121,128	cholecystokinin	12,27	alcohol	cholecystokinin	CHEBI:16236	25298(Tax:10116)	Chemical	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	The role of cholecystokinin -LRB- CCK -RRB- , CCK-A or CCK-B_receptor antagonists in the spontaneous preference for drugs of abuse -LRB- alcohol or cocaine -RRB- in naive rats .
12223536	0	alcohol	85,92	corticotropin-releasing_factor	12,42	alcohol	corticotropin-releasing factor	CHEBI:16236	81648(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of corticotropin-releasing_factor in the median raphe nucleus in relapse to alcohol .
21682752	0	alcohol	22,29	cytokeratin-18	83,97	alcohol	cytokeratin-18	CHEBI:16236	3875	Chemical	Gene	consumption|compound|START_ENTITY effect|nmod|consumption effect|nmod|END_ENTITY	Synergistic effect of alcohol consumption and body mass on serum concentrations of cytokeratin-18 .
1999395	0	alcohol	24,31	dehydrogenase	42,55	alcohol	dehydrogenase	CHEBI:16236	1117606(Tax:272562)	Chemical	Gene	cloning|nmod|START_ENTITY END_ENTITY|nsubj|cloning	Molecular cloning of an alcohol -LRB- butanol -RRB- dehydrogenase gene cluster from Clostridium_acetobutylicum ATCC 824 .
2502790	0	alcohol	71,78	dopa-decarboxylase	20,38	alcohol	dopa-decarboxylase	CHEBI:16236	24311(Tax:10116)	Chemical	Gene	drinking|compound|START_ENTITY END_ENTITY|nmod|drinking	Inhibition of brain dopa-decarboxylase by RO 4-4602 infused ICV blocks alcohol drinking induced in rats by cyanamide .
14756717	0	alcohol	83,90	dopamine_D4_receptor	8,28	alcohol	dopamine D4 receptor	CHEBI:16236	1815	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Reduced dopamine_D4_receptor mRNA expression in lymphocytes of long-term abstinent alcohol and heroin addicts .
17508995	0	alcohol	149,156	dopamine_D4_receptor	21,41	alcohol	dopamine D4 receptor	CHEBI:16236	1815	Chemical	Gene	exposure|compound|START_ENTITY cue-reactivity|nmod|exposure related|nmod|cue-reactivity related|nsubjpass|Polymorphisms Polymorphisms|nmod|gene gene|amod|END_ENTITY	Polymorphisms of the dopamine_D4_receptor gene -LRB- DRD4 VNTR -RRB- and cannabinoid CB1 receptor gene -LRB- CNR1 -RRB- are not strongly related to cue-reactivity after alcohol exposure .
20610847	0	alcohol	111,118	dopamine_D4_receptor	56,76	alcohol	dopamine D4 receptor	CHEBI:16236	1815	Chemical	Gene	use|compound|START_ENTITY adaptation|nmod|use affects|dobj|adaptation affects|nsubj|polymorphism polymorphism|nmod|gene gene|amod|END_ENTITY	A variable-number-of-tandem-repeats polymorphism in the dopamine_D4_receptor gene affects social adaptation of alcohol use : investigation of a gene-environment interaction .
23078267	0	alcohol	55,62	endothelial_nitric_oxide_synthase	72,105	alcohol	endothelial nitric oxide synthase	CHEBI:16236	287024(Tax:9913)	Chemical	Gene	exposed|nmod|START_ENTITY exposed|dobj|role role|nmod|END_ENTITY	Proteomic analysis of bovine axonemes exposed to acute alcohol : role of endothelial_nitric_oxide_synthase and heat_shock protein 90 in cilia stimulation .
24300283	0	alcohol	43,50	endothelial_nitric_oxide_synthase	72,105	alcohol	endothelial nitric oxide synthase	CHEBI:16236	4846	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nsubj|effects	Interactive effects of in vitro binge-like alcohol and ATP on umbilical endothelial_nitric_oxide_synthase post-translational modifications and redox modulation .
10652628	0	alcohol	76,83	epidermal_growth_factor_receptor	13,45	alcohol	epidermal growth factor receptor	CHEBI:16236	1956	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|expression expression|compound|END_ENTITY	Induction of epidermal_growth_factor_receptor expression and mitogenesis by alcohol in human colon_adenocarcinoma-derived Caco-2 cells .
24653683	0	alcohol	88,95	extracellular_signal-regulated_kinase	9,46	alcohol	extracellular signal-regulated kinase	CHEBI:16236	5594	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Neuronal extracellular_signal-regulated_kinase -LRB- ERK -RRB- activity as marker and mediator of alcohol and opioid_dependence .
11440718	0	alcohol	100,107	fasciclinII	11,22	alcohol	fasciclinII	CHEBI:16236	31364(Tax:7227)	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Drosophila fasciclinII is required for the formation of odor memories and for normal sensitivity to alcohol .
11583727	0	alcohol	66,73	gamma-glutamyl_transpeptidase	33,62	alcohol	gamma-glutamyl transpeptidase	CHEBI:16236	92086	Chemical	Gene	drinking|compound|START_ENTITY END_ENTITY|nmod|drinking	Relationship between response of gamma-glutamyl_transpeptidase to alcohol drinking and risk factors for coronary_heart_disease .
2573096	0	alcohol	20,27	gamma-glutamyl_transpeptidase	31,60	alcohol	gamma-glutamyl transpeptidase	CHEBI:16236	116568(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of prenatal alcohol on gamma-glutamyl_transpeptidase in various brain regions .
28553	0	alcohol	52,59	gamma-glutamyl_transpeptidase	10,39	alcohol	gamma-glutamyl transpeptidase	CHEBI:16236	116568(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|dep|effects	Rat brain gamma-glutamyl_transpeptidase : effects of alcohol .
30937	0	alcohol	72,79	gamma-glutamyl_transpeptidase	6,35	alcohol	gamma-glutamyl transpeptidase	CHEBI:16236	92086	Chemical	Gene	consumption|compound|START_ENTITY determinant|nmod|consumption acitvity|dep|determinant acitvity|amod|END_ENTITY	Serum gamma-glutamyl_transpeptidase acitvity : a chemical determinant of alcohol consumption during adolescence .
2222285	0	alcohol	14,21	gastrin	42,49	alcohol	gastrin	CHEBI:16236	2520	Chemical	Gene	ingestion|compound|START_ENTITY ingestion|nmod|END_ENTITY	-LSB- Influence of alcohol ingestion on plasma gastrin and CCK levels in human beings -RSB- .
4564861	0	alcohol	12,19	gastrin	23,30	alcohol	gastrin	CHEBI:16236	2520	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	-LSB- Effects of alcohol on gastrin secretion -RSB- .
24588206	0	alcohol	28,35	gonadotropin-releasing_hormone	98,128	alcohol	gonadotropin-releasing hormone	CHEBI:16236	25194(Tax:10116)	Chemical	Gene	Actions|nmod|START_ENTITY Actions|nmod|END_ENTITY	Actions and interactions of alcohol and transforming_growth_factor_b1 on prepubertal hypothalamic gonadotropin-releasing_hormone .
10550002	0	alcohol	19,26	growth_hormone	67,81	alcohol	growth hormone	CHEBI:16236	81668(Tax:10116)	Chemical	Gene	exposure|compound|START_ENTITY exposure|nmod|regulation regulation|nmod|release release|amod|END_ENTITY	Influence of fetal alcohol exposure on the GABAergic regulation of growth_hormone release in postnatal rats .
1249189	0	alcohol	11,18	growth_hormone	22,36	alcohol	growth hormone	CHEBI:16236	2688	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|amod|END_ENTITY	Effects of alcohol on growth_hormone secretion in acromegaly .
1263833	0	alcohol	10,17	growth_hormone	43,57	alcohol	growth hormone	CHEBI:16236	2688	Chemical	Gene	administration|compound|START_ENTITY Effect|nmod|administration END_ENTITY|nsubj|Effect	Effect of alcohol administration on plasma growth_hormone response to insulin-induced hypoglycemia .
19879987	0	alcohol	11,18	growth_hormone	43,57	alcohol	growth hormone	CHEBI:16236	81668(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|acl|END_ENTITY	Effects of alcohol on skeletal response to growth_hormone in hypophysectomized rats .
6473616	0	alcohol	55,62	growth_hormone	32,46	alcohol	growth hormone	CHEBI:16236	2688	Chemical	Gene	habits|compound|START_ENTITY test|nmod|habits test|nsubj|dependence dependence|nmod|END_ENTITY	The dependence of the clonidine growth_hormone test on alcohol drinking habits and the menstrual cycle .
7419664	0	alcohol	10,17	growth_hormone	48,62	alcohol	growth hormone	CHEBI:16236	2688	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of alcohol on sleep and nighttime plasma growth_hormone and cortisol concentrations .
21447001	0	alcohol	11,18	histone_deacetylase_2	22,43	alcohol	histone deacetylase 2	CHEBI:16236	3066	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of alcohol on histone_deacetylase_2 -LRB- HDAC2 -RRB- and the neuroprotective role of trichostatin_A -LRB- TSA -RRB- .
12020337	0	alcohol	20,27	insulin	46,53	alcohol	insulin	CHEBI:16236	3630	Chemical	Gene	intake|compound|START_ENTITY intake|nmod|END_ENTITY	Effects of moderate alcohol intake on fasting insulin and glucose concentrations and insulin sensitivity in postmenopausal women : a randomized controlled trial .
26388538	0	alcohol	6,13	lipoprotein_lipase	40,58	alcohol	lipoprotein lipase	D000431	4023	Chemical	Gene	consumption|compound|START_ENTITY downregulates|nsubj|consumption downregulates|dobj|activity activity|amod|END_ENTITY	Acute alcohol consumption downregulates lipoprotein_lipase activity in vivo .
7609317	0	alcohol	116,123	lipoprotein_lipase	65,83	alcohol	lipoprotein lipase	CHEBI:16236	4023	Chemical	Gene	-RSB-|compound|START_ENTITY cessation|nmod|-RSB- improvement|nmod|cessation hypertriglyceridemia|dep|improvement hypertriglyceridemia|nmod|subjects subjects|nmod|END_ENTITY	-LSB- Alcohol-induced hypertriglyceridemia in subjects with decreased lipoprotein_lipase -- improvement after cessation of alcohol intake -RSB- .
7840818	0	alcohol	11,18	lipoprotein_lipase	22,40	alcohol	lipoprotein lipase	CHEBI:16236	4023	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of alcohol on lipoprotein_lipase , hepatic_lipase , cholesteryl_ester_transfer_protein , and lecithin : cholesterol_acyltransferase in high-density lipoprotein cholesterol elevation .
22442136	0	alcohol	102,109	mTORC1	70,76	alcohol	mTORC1	CHEBI:16236	382056(Tax:10090)	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Rag GTPases and AMPK/TSC2/Rheb mediate the differential regulation of mTORC1 signaling in response to alcohol and leucine .
7487113	0	alcohol	70,77	manganese_superoxide_dismutase	27,57	alcohol	manganese superoxide dismutase	CHEBI:16236	6648	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|activity activity|amod|END_ENTITY	Differential regulation of manganese_superoxide_dismutase activity by alcohol and TNF in human hepatoma cells .
23531254	0	alcohol	8,15	nam	52,55	alcohol	nam	CHEBI:16236	246329	Chemical	Gene	Role|nmod|START_ENTITY END_ENTITY|nsubj|Role	Role of alcohol in hospitalized road trauma in Viet nam .
21392176	0	alcohol	57,64	nerve_growth_factor	30,49	alcohol	nerve growth factor	CHEBI:16236	4803	Chemical	Gene	withdrawal|compound|START_ENTITY END_ENTITY|nmod|withdrawal	Epigenetic down regulation of nerve_growth_factor during alcohol withdrawal .
12818714	0	alcohol	29,36	neuropeptide_Y	11,25	alcohol	neuropeptide Y	CHEBI:16236	4852	Chemical	Gene	control|compound|START_ENTITY END_ENTITY|nmod|control	A role for neuropeptide_Y in alcohol intake control : evidence from human and animal research .
9952048	0	alcohol	24,31	nociceptin	10,20	alcohol	nociceptin	CHEBI:16236	25516(Tax:10116)	Chemical	Gene	intake|compound|START_ENTITY Effect|nmod|intake Effect|nmod|END_ENTITY	Effect of nociceptin on alcohol intake in alcohol-preferring rats .
12620823	0	alcohol	133,140	oxidoreductase	141,155	alcohol	oxidoreductase	CHEBI:16236	9538117	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Construction and screening of metagenomic libraries derived from enrichment cultures : generation of a gene bank for genes conferring alcohol oxidoreductase activity on Escherichia_coli .
21084795	0	alcohol	141,148	part_1	263,269	alcohol	part 1	CHEBI:16236	25859	Chemical	Gene	abstinence|nmod|START_ENTITY patients|nmod|abstinence neurological_dysregulation|nmod|patients neurological_dysregulation|dep|study study|amod|END_ENTITY	Acute intravenous synaptamine complex variant KB220 `` normalizes '' neurological_dysregulation in patients during protracted abstinence from alcohol and opiates as observed using quantitative electroencephalographic and genetic analysis for reward polymorphisms : part_1 , pilot study with 2 case reports .
19285340	0	alcohol	11,18	parvalbumin	36,47	alcohol	parvalbumin	CHEBI:16236	25269(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|nmod|END_ENTITY	Effects of alcohol on the levels of parvalbumin in rat hearts .
10397281	0	alcohol	16,23	prolactin	61,70	alcohol	prolactin	CHEBI:16236	5617	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|cortisol cortisol|dep|END_ENTITY	Acute effect of alcohol on estradiol , estrone , progesterone , prolactin , cortisol , and luteinizing hormone in premenopausal women .
16516235	0	alcohol	47,54	prolactin	9,18	alcohol	prolactin	CHEBI:16236	5617	Chemical	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	Elevated prolactin serum levels and history of alcohol withdrawal_seizures .
21552201	0	alcohol	8,15	prolactin	47,56	alcohol	prolactin	CHEBI:16236	24683(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY increases|nsubj|administration increases|dobj|level level|compound|END_ENTITY	Chronic alcohol administration increases serum prolactin level and pituitary cell proliferation , and alters hypothalamus neurotransmitters in rat .
2264609	0	alcohol	49,56	prolactin	98,107	alcohol	prolactin	CHEBI:16236	24683(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY Pattern|nmod|effect administered|nsubj|Pattern administered|nmod|END_ENTITY	Pattern and duration of the inhibitory effect of alcohol administered acutely on suckling-induced prolactin in lactating rats .
3283782	0	alcohol	71,78	prolactin	17,26	alcohol	prolactin	CHEBI:16236	24683(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY role|nmod|treatment role|nmod|END_ENTITY	Possible role of prolactin in the induction of hypogonadism by chronic alcohol treatment in the male rat .
3757769	0	alcohol	54,61	prolactin	6,15	alcohol	prolactin	CHEBI:16236	5617	Chemical	Gene	withdrawal|compound|START_ENTITY correlates|nmod|withdrawal correlates|nsubj|END_ENTITY	Serum prolactin correlates with depressed mood during alcohol withdrawal .
9401675	0	alcohol	91,98	prolactin	37,46	alcohol	prolactin	CHEBI:16236	24683(Tax:10116)	Chemical	Gene	exposed|nmod|START_ENTITY exposed|nsubj|increases increases|nmod|levels levels|compound|END_ENTITY	Sulpiride-induced increases in serum prolactin levels in female rats exposed prenatally to alcohol .
16829625	0	alcohol	52,59	retinoid_X_receptor_alpha	12,37	alcohol	retinoid X receptor alpha	CHEBI:16236	20181(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY regulating|dobj|metabolism END_ENTITY|acl|regulating	The role of retinoid_X_receptor_alpha in regulating alcohol metabolism .
18422838	0	alcohol	45,52	tachykinin_receptor_3	4,25	alcohol	tachykinin receptor 3	CHEBI:16236	6870	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	The tachykinin_receptor_3 is associated with alcohol and cocaine_dependence .
22124290	0	alcohol	44,51	task	10,14	alcohol	task	CHEBI:16236	3777	Chemical	Gene	usage|compound|START_ENTITY performance|nmod|usage performance|compound|END_ENTITY	Cognitive task performance and frequency of alcohol usage in young adults .
25443132	0	alcohol	58,65	tax	66,69	alcohol	tax	CHEBI:16236	6900	Chemical	Gene	policy|compound|START_ENTITY policy|compound|END_ENTITY	Inpatient expenditures on alcohol-attributed_diseases and alcohol tax policy : a nationwide analysis in Taiwan from 1996 to 2010 .
15795656	0	alcohol	90,97	transferrin	23,34	alcohol	transferrin	CHEBI:16236	7018	Chemical	Gene	consumption|compound|START_ENTITY END_ENTITY|nmod|consumption	Carbohydrate-deficient transferrin and gamma-glutamyl_transpeptidase in the evaluation of alcohol consumption .
7847591	0	alcohol	61,68	transferrin	23,34	alcohol	transferrin	CHEBI:16236	7018	Chemical	Gene	consumption|compound|START_ENTITY END_ENTITY|nmod|consumption	Carbohydrate-deficient transferrin and other markers of high alcohol consumption : a study of 502 patients admitted consecutively to a medical department .
8048718	0	alcohol	57,64	transferrin	23,34	alcohol	transferrin	CHEBI:16236	7018	Chemical	Gene	consumption|compound|START_ENTITY END_ENTITY|nmod|consumption	Carbohydrate-deficient transferrin during 3 weeks ' heavy alcohol consumption .
9884140	0	alcohol	60,67	transferrin	23,34	alcohol	transferrin	CHEBI:16236	7018	Chemical	Gene	intake|compound|START_ENTITY END_ENTITY|nmod|intake	Carbohydrate-deficient transferrin as a marker of change in alcohol intake in men drinking 20 to 60 g of alcohol per day .
1984333	0	alcohol	18,25	transketolase	44,57	alcohol	transketolase	CHEBI:16236	64524(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY administration|nmod|END_ENTITY	Effect of chronic alcohol administration on transketolase in the brain and the liver of rats .
11022015	0	alcohol	67,74	tryptophan_pyrrolase	10,30	alcohol	tryptophan pyrrolase	CHEBI:16236	64206(Tax:10116)	Chemical	Gene	withdrawal|compound|START_ENTITY END_ENTITY|nmod|withdrawal	Rat liver tryptophan_pyrrolase activity and gene expression during alcohol withdrawal .
12198381	0	alcohol	10,17	tumor_necrosis_factor-alpha	38,65	alcohol	tumor necrosis factor-alpha	CHEBI:16236	24835(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|nmod|END_ENTITY	Effect of alcohol on the secretion of tumor_necrosis_factor-alpha by macrophages in the presence of rat serum .
12960512	0	alcohol	80,87	tumor_necrosis_factor-alpha	18,45	alcohol	tumor necrosis factor-alpha	CHEBI:16236	24835(Tax:10116)	Chemical	Gene	loading|compound|START_ENTITY rats|nmod|loading macrophages|nmod|rats production|nmod|macrophages production|nmod|END_ENTITY	The production of tumor_necrosis_factor-alpha by macrophages in rats with acute alcohol loading .
14693987	0	alcohol	19,26	tumor_necrosis_factor-alpha	55,82	alcohol	tumor necrosis factor-alpha	CHEBI:16236	7124	Chemical	Gene	consumption|compound|START_ENTITY Effect|nmod|consumption Effect|nmod|END_ENTITY	Effect of moderate alcohol consumption on adiponectin , tumor_necrosis_factor-alpha , and insulin sensitivity .
8781508	0	alcohol	18,25	tumor_necrosis_factor-alpha	49,76	alcohol	tumor necrosis factor-alpha	CHEBI:16236	24835(Tax:10116)	Chemical	Gene	consumption|compound|START_ENTITY consumption|nmod|rats rats|nmod|clearance clearance|amod|END_ENTITY	Effect of chronic alcohol consumption by rats on tumor_necrosis_factor-alpha and interleukin-6 clearance in vivo and by the isolated , perfused liver .
9394127	0	alcohol	8,15	tumor_necrosis_factor-alpha	35,62	alcohol	tumor necrosis factor-alpha	CHEBI:16236	24835(Tax:10116)	Chemical	Gene	ingestion|compound|START_ENTITY enhances|nsubj|ingestion enhances|dobj|expression expression|amod|END_ENTITY	Chronic alcohol ingestion enhances tumor_necrosis_factor-alpha expression and salivary gland apoptosis .
7726757	0	alcoholics	21,31	ADH3	66,70	alcoholics	ADH3	null	126	Chemical	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	-LSB- Association between alcoholics and the genotypes of ALDH2 , ADH2 , ADH3 as well as P-4502E1 -RSB- .
9347091	0	alcoholics	67,77	CRF	60,63	alcoholics	CRF	null	1392	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Endocrine and hemodynamic effects of stress versus systemic CRF in alcoholics during early and medium term abstinence .
10551544	0	alcoholics	71,81	Dopamine_D4_receptor	0,20	alcoholics	Dopamine D4 receptor	null	1815	Chemical	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Dopamine_D4_receptor gene and personality dimensions in Brazilian male alcoholics .
20043000	0	alcoholics	94,104	SOD2	15,19	alcoholics	SOD2	null	6648	Chemical	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of SOD2 , a mitochondrial antioxidant enzyme , with gray matter volume shrinkage in alcoholics .
19885717	0	alcoholics	76,86	Serotonin_transporter	0,21	alcoholics	Serotonin transporter	null	6532	Chemical	Gene	polymorphism|nmod|START_ENTITY polymorphism|amod|END_ENTITY	Serotonin_transporter promoter polymorphism and dopaminergic sensitivity in alcoholics .
2870657	0	alcoholics	51,61	gamma-Glutamyl_transpeptidase	0,29	alcoholics	gamma-Glutamyl transpeptidase	null	92086	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	gamma-Glutamyl_transpeptidase activity in liver of alcoholics and its localization .
2894783	0	alcoholics	178,188	gamma-glutamyl_transpeptidase	136,165	alcoholics	gamma-glutamyl transpeptidase	null	92086	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Alcohol-induced enhancement of intestinal gamma-glutamyl_transpeptidase activity in rats and humans : a possible role in increased serum gamma-glutamyl_transpeptidase activity in alcoholics .
8488965	0	alcoholics	78,88	monoamine_oxidase_B	28,47	alcoholics	monoamine oxidase B	null	4129	Chemical	Gene	study|nmod|START_ENTITY study|nmod|activity activity|compound|END_ENTITY	A genetic familial study of monoamine_oxidase_B activity and concentration in alcoholics .
8214416	0	alcoholics	71,81	thyrotropin-releasing_hormone	9,38	alcoholics	thyrotropin-releasing hormone	null	7200	Chemical	Gene	effects|nmod|START_ENTITY effects|amod|END_ENTITY	Low-dose thyrotropin-releasing_hormone effects in cognitively impaired alcoholics .
2965919	0	alcohols	15,23	ATPase	46,52	alcohols	ATPase	MESH:D000438	1769	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|activity activity|amod|END_ENTITY	-LSB- Regulation by alcohols and anions of soluble ATPase activity in chloroplasts and mitochondria -RSB- .
17937984	0	alcohols	53,61	Chk2	108,112	alcohols	Chk2	MESH:D000438	11200	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	2-Aryl_benzimidazoles featuring alkyl-linked pendant alcohols and amines as inhibitors of checkpoint kinase Chk2 .
12795	0	alcohols	10,18	D-amino-acid_oxidase	52,72	alcohols	D-amino-acid oxidase	MESH:D000438	1610	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|structure structure|nmod|END_ENTITY	Effect of alcohols on the structure and function of D-amino-acid_oxidase .
8735641	0	alcohols	22,30	GABAA	34,39	alcohols	GABAA	MESH:D000438	14405(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|receptors receptors|compound|END_ENTITY	Actions of long chain alcohols on GABAA and glutamate receptors : relation to in vivo effects .
25641189	0	alcohols	61,69	alcohol_dehydrogenase	22,43	alcohols	alcohol dehydrogenase	MESH:D000438	78959(Tax:10116)	Chemical	Gene	metabolism|nmod|START_ENTITY END_ENTITY|nmod|metabolism	Contribution of liver alcohol_dehydrogenase to metabolism of alcohols in rats .
25641189	0	alcohols	61,69	alcohol_dehydrogenase	22,43	alcohols	alcohol dehydrogenase	MESH:D000438	78959(Tax:10116)	Chemical	Gene	metabolism|nmod|START_ENTITY END_ENTITY|nmod|metabolism	Contribution of liver alcohol_dehydrogenase to metabolism of alcohols in rats .
7016531	0	alcohols	92,100	alcohol_dehydrogenase	116,137	alcohols	alcohol dehydrogenase	MESH:D000438	10327	Chemical	Gene	START_ENTITY|acl|bound bound|nmod|END_ENTITY	Substituent effects on the ionization step regulating desorption and catalytic oxidation of alcohols bound to liver alcohol_dehydrogenase .
15983424	0	alcohols	112,120	lysozyme	84,92	alcohols	lysozyme	MESH:D000438	4069	Chemical	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	Effect of alcohols on protein hydration : crystallographic analysis of hen egg-white lysozyme in the presence of alcohols .
15618645	0	alcohols	22,30	matrix_metalloproteinase_7	56,82	alcohols	matrix metalloproteinase 7	MESH:D000438	4316	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Inhibitory effects of alcohols on the activity of human matrix_metalloproteinase_7 -LRB- matrilysin -RRB- .
1111641	0	alcohols	15,23	monoamine_oxidase	41,58	alcohols	monoamine oxidase	MESH:D000438	29253(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- The effect of alcohols on mitochondrial monoamine_oxidase activity -RSB- .
7629033	0	alcohols	11,19	neuraminidase	83,96	alcohols	neuraminidase	MESH:D000438	4758	Chemical	Gene	Effects|nmod|START_ENTITY catalyzed|nsubj|Effects catalyzed|nmod|END_ENTITY	Effects of alcohols on the hydrolysis of colominic_acid catalyzed by Streptococcus neuraminidase .
10567370	0	alcohols	63,71	protein_kinase_C-alpha	30,52	alcohols	protein kinase C-alpha	MESH:D000438	5578	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Lipid-dependent activation of protein_kinase_C-alpha by normal alcohols .
11870853	0	aldehyde	120,128	ALD6	115,119	aldehyde	ALD6	CHEBI:17478	856044(Tax:4932)	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Decreasing acetic_acid accumulation by a glycerol overproducing strain of Saccharomyces_cerevisiae by deleting the ALD6 aldehyde dehydrogenase gene .
18834868	0	aldehyde	14,22	ALDH-2	38,44	aldehyde	ALDH-2	CHEBI:17478	217	Chemical	Gene	dehydrogenase|compound|START_ENTITY dehydrogenase|appos|END_ENTITY	Mitochondrial aldehyde dehydrogenase -LRB- ALDH-2 -RRB- -- maker of and marker for nitrate tolerance in response to nitroglycerin treatment .
20072908	0	aldehyde	44,52	ALDH-2	68,74	aldehyde	ALDH-2	CHEBI:17478	217	Chemical	Gene	dehydrogenase|compound|START_ENTITY activity|nmod|dehydrogenase activity|appos|END_ENTITY	Nitrate reductase activity of mitochondrial aldehyde dehydrogenase -LRB- ALDH-2 -RRB- as a redox sensor for cardiovascular oxidative stress .
21252222	0	aldehyde	34,42	ALDH-2	58,64	aldehyde	ALDH-2	CHEBI:17478	217	Chemical	Gene	START_ENTITY|dobj|activity activity|appos|END_ENTITY	Regulation of human mitochondrial aldehyde dehydrogenase -LRB- ALDH-2 -RRB- activity by electrophiles in vitro .
12234608	0	aldehyde	45,53	ALDH1	139,144	aldehyde	ALDH1	CHEBI:17478	11668(Tax:10090)	Chemical	Gene	dehydrogenase|amod|START_ENTITY inhibitors|nmod|dehydrogenase inhibitors|dep|restoration restoration|nmod|chemosensitivity chemosensitivity|nmod|cells cells|acl|overexpressing overexpressing|dobj|END_ENTITY	Novel competitive irreversible inhibitors of aldehyde dehydrogenase -LRB- ALDH1 -RRB- : restoration of chemosensitivity of L1210 cells overexpressing ALDH1 and induction of apoptosis in BAF -LRB- 3 -RRB- cells overexpressing bcl -LRB- 2 -RRB- .
12234608	0	aldehyde	45,53	ALDH1	69,74	aldehyde	ALDH1	CHEBI:17478	11668(Tax:10090)	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	Novel competitive irreversible inhibitors of aldehyde dehydrogenase -LRB- ALDH1 -RRB- : restoration of chemosensitivity of L1210 cells overexpressing ALDH1 and induction of apoptosis in BAF -LRB- 3 -RRB- cells overexpressing bcl -LRB- 2 -RRB- .
19336570	3	aldehyde	537,545	ALDH1	563,568	aldehyde	ALDH1	CHEBI:17478	216	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	Accordingly , aldehyde dehydrogenase 1 -LRB- ALDH1 -RRB- was investigated as a possible marker for identifying colonic SC and for tracking them during cancer progression .
20010944	0	aldehyde	14,22	ALDH1	40,45	aldehyde	ALDH1	CHEBI:17478	216	Chemical	Gene	dehydrogenase|compound|START_ENTITY Expression|nmod|dehydrogenase Expression|appos|END_ENTITY	Expression of aldehyde dehydrogenase 1 -LRB- ALDH1 -RRB- is associated with basal-like markers and features of aggressive_tumours in African breast_cancer .
22101256	0	aldehyde	26,34	ALDH1	52,57	aldehyde	ALDH1	CHEBI:17478	216	Chemical	Gene	dehydrogenase|compound|START_ENTITY pattern|nmod|dehydrogenase pattern|appos|END_ENTITY	The expression pattern of aldehyde dehydrogenase 1 -LRB- ALDH1 -RRB- is an independent prognostic marker for low survival in colorectal_tumors .
24197864	0	aldehyde	20,28	ALDH1	54,59	aldehyde	ALDH1	CHEBI:17478	216	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Hypoxia upregulates aldehyde dehydrogenase isoform 1 -LRB- ALDH1 -RRB- expression and induces functional stem cell characteristics in human glioblastoma cells .
24338721	0	aldehyde	17,25	ALDH1	43,48	aldehyde	ALDH1	CHEBI:17478	216	Chemical	Gene	dehydrogenase|nsubj|START_ENTITY dehydrogenase|dep|expressing expressing|nsubj|1 1|appos|END_ENTITY	Stem cell marker aldehyde dehydrogenase 1 -LRB- ALDH1 -RRB- - expressing cells are enriched in triple-negative_breast_cancer .
25009786	0	aldehyde	106,114	ALDH1	130,135	aldehyde	ALDH1	CHEBI:17478	216	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|dep|END_ENTITY	Retroviral-infection increases tumorigenic potential of MDA-MB-231 breast_carcinoma cells by expanding an aldehyde dehydrogenase -LRB- ALDH1 -RRB- positive stem-cell like population .
26148881	0	aldehyde	18,26	ALDH1	44,49	aldehyde	ALDH1	D000079	216	Chemical	Gene	expression|nmod|START_ENTITY dehydrogenase|nsubj|expression dehydrogenase|dobj|1 1|appos|END_ENTITY	The expression of aldehyde dehydrogenase 1 -LRB- ALDH1 -RRB- in ovarian_carcinomas and its clinicopathological associations : a retrospective study .
26619843	0	aldehyde	39,47	ALDH1	65,70	aldehyde	ALDH1	D000079	216	Chemical	Gene	value|nmod|START_ENTITY dehydrogenase|nsubj|value dehydrogenase|dobj|1 1|appos|END_ENTITY	Expression and prognostic value of the aldehyde dehydrogenase 1 -LRB- ALDH1 -RRB- and N-myc_downstream_regulated_gene_2 -LRB- NDRG2 -RRB- as potential markers in human astrocytomas .
27015121	0	aldehyde	16,24	ALDH1	42,47	aldehyde	ALDH1	D000079	216	Chemical	Gene	dehydrogenase|nsubj|START_ENTITY dehydrogenase|ccomp|isoenzymes isoenzymes|nsubj|1 1|appos|END_ENTITY	Mining distinct aldehyde dehydrogenase 1 -LRB- ALDH1 -RRB- isoenzymes in gastric_cancer .
2729894	0	aldehyde	10,18	ALDH1	34,39	aldehyde	ALDH1	CHEBI:17478	216	Chemical	Gene	dehydrogenase|compound|START_ENTITY variants|compound|dehydrogenase variants|appos|END_ENTITY	Cytosolic aldehyde dehydrogenase -LRB- ALDH1 -RRB- variants found in alcohol flushers .
9251525	0	aldehyde	16,24	ALDH1	40,45	aldehyde	ALDH1	CHEBI:17478	24188(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|polymorphism polymorphism|appos|END_ENTITY	Liver cytosolic aldehyde dehydrogenase -LRB- ALDH1 -RRB- polymorphism and its inheritance in Wistar_rats .
11914911	0	aldehyde	19,27	ALDH1A1	44,51	aldehyde	ALDH1A1	CHEBI:17478	216	Chemical	Gene	dehydrogenases|amod|START_ENTITY dehydrogenases|appos|END_ENTITY	Cellular levels of aldehyde dehydrogenases -LRB- ALDH1A1 and ALDH3A1 -RRB- as predictors of therapeutic responses to cyclophosphamide-based chemotherapy of breast_cancer : a retrospective study .
12941160	0	aldehyde	67,75	ALDH1A1	91,98	aldehyde	ALDH1A1	CHEBI:17478	100008636(Tax:9986)	Chemical	Gene	cloning|nmod|START_ENTITY dehydrogenase|nsubj|cloning dehydrogenase|dobj|cDNA cDNA|appos|END_ENTITY	Molecular cloning and baculovirus expression of the rabbit corneal aldehyde dehydrogenase -LRB- ALDH1A1 -RRB- cDNA .
19129088	0	aldehyde	12,20	ALDH1A1	38,45	aldehyde	ALDH1A1	CHEBI:17478	216	Chemical	Gene	dehydrogenase-1|amod|START_ENTITY polymorphisms|amod|dehydrogenase-1 polymorphisms|appos|END_ENTITY	The role of aldehyde dehydrogenase-1 -LRB- ALDH1A1 -RRB- polymorphisms in harmful alcohol consumption in a Finnish population .
21784415	0	aldehyde	27,35	ALDH1A1	50,57	aldehyde	ALDH1A1	CHEBI:17478	216	Chemical	Gene	significance|nmod|START_ENTITY dehydrogenase|nsubj|significance dehydrogenase|dobj|END_ENTITY	Functional significance of aldehyde dehydrogenase ALDH1A1 to the nigrostriatal dopamine system .
10397279	0	aldehyde	53,61	ALDH2	77,82	aldehyde	ALDH2	CHEBI:17478	217	Chemical	Gene	dehydrogenase|compound|START_ENTITY dehydrogenase|appos|END_ENTITY	An A/G polymorphism in the promoter of mitochondrial aldehyde dehydrogenase -LRB- ALDH2 -RRB- : effects of the sequence variant on transcription factor binding and promoter strength .
10803776	0	aldehyde	69,77	ALDH2	93,98	aldehyde	ALDH2	CHEBI:17478	217	Chemical	Gene	dehydrogenase|compound|START_ENTITY genotypes|nmod|dehydrogenase respect|nmod|genotypes alcoholism|nmod|respect markers|nmod|alcoholism markers|appos|END_ENTITY	Biological markers of alcoholism with respect to genotypes of low-Km aldehyde dehydrogenase -LRB- ALDH2 -RRB- in Japanese subjects .
11505017	0	aldehyde	73,81	ALDH2	97,102	aldehyde	ALDH2	CHEBI:17478	11669(Tax:10090)	Chemical	Gene	dehydrogenase|compound|START_ENTITY dehydrogenase|appos|END_ENTITY	Peroxisome_proliferator-activated_receptors -LRB- PPAR -RRB- and the mitochondrial aldehyde dehydrogenase -LRB- ALDH2 -RRB- promoter in vitro and in vivo .
12380847	0	aldehyde	22,30	ALDH2	46,51	aldehyde	ALDH2	CHEBI:17478	217	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	The effects of low Km aldehyde dehydrogenase -LRB- ALDH2 -RRB- phenotype on drinking behavior in Japanese university students .
16440063	0	aldehyde	14,22	ALDH2	40,45	aldehyde	ALDH2	CHEBI:17478	217	Chemical	Gene	START_ENTITY|ccomp|contributes contributes|nsubj|polymorphism polymorphism|appos|END_ENTITY	Mitochondrial aldehyde dehydrogenase-2 -LRB- ALDH2 -RRB- Glu504Lys polymorphism contributes to the variation in efficacy of sublingual nitroglycerin .
18201725	0	aldehyde	33,41	ALDH2	62,67	aldehyde	ALDH2	CHEBI:17478	217	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The association of mitochondrial aldehyde dehydrogenase gene -LRB- ALDH2 -RRB- polymorphism with susceptibility to late-onset Alzheimer 's _ disease in Chinese .
18772068	0	aldehyde	121,129	ALDH2	147,152	aldehyde	ALDH2	CHEBI:17478	217	Chemical	Gene	response|nmod|START_ENTITY calcitonin_gene-related_peptide|nmod|response polymorphism|amod|calcitonin_gene-related_peptide polymorphism|appos|END_ENTITY	Evidence for involvement of calcitonin_gene-related_peptide in nitroglycerin response and association with mitochondrial aldehyde dehydrogenase-2 -LRB- ALDH2 -RRB- Glu504Lys polymorphism .
20575845	0	aldehyde	53,61	ALDH2	114,119	aldehyde	ALDH2	CHEBI:17478	217	Chemical	Gene	dehydrogenase|compound|START_ENTITY alcoholics|nmod|dehydrogenase Characteristics|nmod|alcoholics Characteristics|dep|features features|nmod|alcoholics alcoholics|nmod|END_ENTITY	Characteristics of Japanese alcoholics with inactive aldehyde dehydrogenase : clinical features of alcoholics with ALDH2 * 2 .
20705694	1	aldehyde	216,224	ALDH2	240,245	aldehyde	ALDH2	CHEBI:17478	11669(Tax:10090)	Chemical	Gene	dehydrogenase|compound|START_ENTITY dehydrogenase|appos|END_ENTITY	AIMS : The present study was designed to examine the mechanism involved in mitochondrial aldehyde dehydrogenase -LRB- ALDH2 -RRB- - induced cardioprotection against ischaemia/reperfusion -LRB- I/R -RRB- injury with a focus on autophagy .
22102315	0	aldehyde	32,40	ALDH2	61,66	aldehyde	ALDH2	CHEBI:17478	217	Chemical	Gene	dehydrogenase|amod|START_ENTITY 504lys|amod|dehydrogenase 504lys|appos|END_ENTITY	Strong protective effect of the aldehyde dehydrogenase gene -LRB- ALDH2 -RRB- 504lys -LRB- * 2 -RRB- allele against alcoholism and alcohol-induced medical diseases in Asians .
22524197	0	aldehyde	14,22	ALDH2	38,43	aldehyde	ALDH2	CHEBI:17478	11669(Tax:10090)	Chemical	Gene	dehydrogenase|compound|START_ENTITY dehydrogenase|appos|END_ENTITY	Mitochondrial aldehyde dehydrogenase -LRB- ALDH2 -RRB- protects against streptozotocin-induced diabetic_cardiomyopathy : role of GSK3b and mitochondrial function .
24874076	0	aldehyde	47,55	ALDH2	71,76	aldehyde	ALDH2	CHEBI:17478	11669(Tax:10090)	Chemical	Gene	dehydrogenase|compound|START_ENTITY dehydrogenase|appos|END_ENTITY	A novel protective mechanism for mitochondrial aldehyde dehydrogenase -LRB- ALDH2 -RRB- in type_i_diabetes-induced_cardiac_dysfunction : Role of AMPK-regulated autophagy .
6650498	0	aldehyde	36,44	ALDH2	59,64	aldehyde	ALDH2	CHEBI:17478	217	Chemical	Gene	genotypes|nmod|START_ENTITY Determination|nmod|genotypes dehydrogenase|nsubj|Determination dehydrogenase|dobj|locus locus|nummod|END_ENTITY	Determination of genotypes of human aldehyde dehydrogenase ALDH2 locus .
8135666	0	aldehyde	50,58	ALDH2	74,79	aldehyde	ALDH2	CHEBI:17478	217	Chemical	Gene	dehydrogenase|compound|START_ENTITY dehydrogenase|dep|END_ENTITY	-LSB- A characteristic of alcoholics with the atypical aldehyde dehydrogenase -LRB- ALDH2 -LRB- 2 -RRB- -- a relationship to other alcohol metabolizing enzymes -RSB- .
8359813	0	aldehyde	38,46	ALDH2	62,67	aldehyde	ALDH2	CHEBI:17478	217	Chemical	Gene	dehydrogenase|compound|START_ENTITY dehydrogenase|appos|END_ENTITY	Absence of the atypical mitochondrial aldehyde dehydrogenase -LRB- ALDH2 -RRB- isozyme in Saskatchewan Cree Indians .
8561277	0	aldehyde	14,22	ALDH2	109,114	aldehyde	ALDH2	CHEBI:17478	217	Chemical	Gene	polymorphism|amod|START_ENTITY polymorphism|dep|detection detection|nmod|alleles alleles|compound|END_ENTITY	Mitochondrial aldehyde dehydrogenase polymorphism in Asian and American Indian populations : detection of new ALDH2 alleles .
8781384	0	aldehyde	7,15	ALDH2	31,36	aldehyde	ALDH2	CHEBI:17478	217	Chemical	Gene	START_ENTITY|dobj|polymorphism polymorphism|appos|END_ENTITY	Low Km aldehyde dehydrogenase -LRB- ALDH2 -RRB- polymorphism , alcohol-drinking behavior , and chromosome alterations in peripheral lymphocytes .
8903321	0	aldehyde	34,42	ALDH2	58,63	aldehyde	ALDH2	CHEBI:17478	217	Chemical	Gene	dehydrogenase|amod|START_ENTITY gene|amod|dehydrogenase gene|appos|END_ENTITY	The mutation in the mitochondrial aldehyde dehydrogenase -LRB- ALDH2 -RRB- gene responsible for alcohol-induced flushing_increases_turnover of the enzyme tetramers in a dominant fashion .
19633610	0	aldehyde	9,17	ALDH3A1	101,108	aldehyde	ALDH3A1	CHEBI:17478	218	Chemical	Gene	dehydrogenase|amod|START_ENTITY activity|dep|dehydrogenase activity|nmod|END_ENTITY	Salivary aldehyde dehydrogenase : activity towards aromatic_aldehydes and comparison with recombinant ALDH3A1 .
8493898	0	aldehyde	20,28	ALDH4	44,49	aldehyde	ALDH4	CHEBI:17478	221	Chemical	Gene	dehydrogenase|compound|START_ENTITY dehydrogenase|appos|END_ENTITY	Human liver high Km aldehyde dehydrogenase -LRB- ALDH4 -RRB- : properties and structural relationship to the glutamic gamma-semialdehyde dehydrogenase .
10191271	0	aldehyde	48,56	Aldh1	107,112	aldehyde	Aldh1	CHEBI:17478	11668(Tax:10090)	Chemical	Gene	genes|amod|START_ENTITY genes|dep|identification identification|nmod|role role|nmod|END_ENTITY	Molecular analysis of two closely related mouse aldehyde dehydrogenase genes : identification of a role for Aldh1 , but not Aldh-pb , in the biosynthesis of retinoic_acid .
9166904	0	aldehyde	14,22	Aldh1	43,48	aldehyde	Aldh1	CHEBI:17478	216	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The cytosolic aldehyde dehydrogenase gene -LRB- Aldh1 -RRB- is developmentally expressed in Leydig cells .
23295222	0	aldehyde	77,85	Aldh1l1	110,117	aldehyde	Aldh1l1	CHEBI:17478	10840	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	The mechanism of discrimination between oxidized and reduced coenzyme in the aldehyde dehydrogenase domain of Aldh1l1 .
20515806	0	aldehyde	52,60	Aldh2	91,96	aldehyde	Aldh2	CHEBI:17478	11669(Tax:10090)	Chemical	Gene	mice|amod|START_ENTITY mice|dep|END_ENTITY	Effects of acetaldehyde inhalation in mitochondrial aldehyde dehydrogenase deficient mice -LRB- Aldh2 - / - -RRB- .
10591537	0	aldehyde	24,32	Aldh3a1	48,55	aldehyde	Aldh3a1	CHEBI:17478	11670(Tax:10090)	Chemical	Gene	dehydrogenase|compound|START_ENTITY dehydrogenase|appos|END_ENTITY	Mouse cytosolic class 3 aldehyde dehydrogenase -LRB- Aldh3a1 -RRB- : gene structure and regulation of constitutive and dioxin-inducible expression .
1483503	0	aldehyde	41,49	BCP_54	65,71	aldehyde	BCP 54	CHEBI:17478	281617(Tax:9913)	Chemical	Gene	dehydrogenase|compound|START_ENTITY dehydrogenase|appos|END_ENTITY	Kinetic properties of the bovine corneal aldehyde dehydrogenase -LRB- BCP_54 -RRB- .
7545914	0	aldehyde	62,70	GAPDH	20,25	aldehyde	GAPDH	CHEBI:17478	542583(Tax:4577)	Chemical	Gene	superfamily|amod|START_ENTITY member|nmod|superfamily member|nsubj|END_ENTITY	Non-phosphorylating GAPDH of higher plants is a member of the aldehyde dehydrogenase superfamily with no sequence homology to phosphorylating GAPDH .
15878704	0	aldehyde	15,23	ICAM-1	53,59	aldehyde	ICAM-1	CHEBI:17478	3383	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	Protocatechuic aldehyde suppresses TNF-alpha-induced ICAM-1 and VCAM-1 expression in human umbilical vein endothelial cells .
10997131	0	aldehyde	24,32	aldA	48,52	aldehyde	aldA	CHEBI:17478	226	Chemical	Gene	dehydrogenase|compound|START_ENTITY dehydrogenase|appos|END_ENTITY	Cloning of the putative aldehyde dehydrogenase , aldA , gene from Streptomyces aureofaciens .
18772068	0	aldehyde	121,129	calcitonin_gene-related_peptide	28,59	aldehyde	calcitonin gene-related peptide	CHEBI:17478	796	Chemical	Gene	response|nmod|START_ENTITY END_ENTITY|nmod|response	Evidence for involvement of calcitonin_gene-related_peptide in nitroglycerin response and association with mitochondrial aldehyde dehydrogenase-2 -LRB- ALDH2 -RRB- Glu504Lys polymorphism .
19356138	0	aldehyde	21,29	cathepsin_G	44,55	aldehyde	cathepsin G	CHEBI:17478	509956(Tax:9913)	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|nmod|END_ENTITY	Low-molecular-weight aldehyde inhibitors of cathepsin_G .
14684342	0	aldehyde	29,37	cathepsin_K	38,49	aldehyde	cathepsin K	CHEBI:17478	1513	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Exploration of the P1 SAR of aldehyde cathepsin_K inhibitors .
15177446	0	aldehyde	32,40	cathepsin_K	41,52	aldehyde	cathepsin K	CHEBI:17478	1513	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Exploration of the P2-P3 SAR of aldehyde cathepsin_K inhibitors .
22224089	0	aldehyde	20,28	cathepsin_K	49,60	aldehyde	cathepsin K	CHEBI:17478	1513	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	A modeling study of aldehyde inhibitors of human cathepsin_K using partial_least_squares method .
9286755	0	aldehyde	8,16	cathepsin_K	31,42	aldehyde	cathepsin K	CHEBI:17478	29175(Tax:10116)	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|nmod|END_ENTITY	Peptide aldehyde inhibitors of cathepsin_K inhibit bone resorption both in vitro and in vivo .
9784105	0	aldehyde	21,29	cathepsin_L	75,86	aldehyde	cathepsin L	CHEBI:17478	1514	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Synthesis of peptide aldehyde derivatives as selective inhibitors of human cathepsin_L and their inhibitory effect on bone resorption .
2155225	1	aldehyde	106,114	cytochrome_P-450LTB_omega	167,192	aldehyde	cytochrome P-450LTB omega	CHEBI:17478	4051	Chemical	Gene	Role|nmod|START_ENTITY Role|dep|END_ENTITY	Role of aldehyde dehydrogenase and leukotriene_B4_omega-hydroxylase -LRB- cytochrome_P-450LTB_omega -RRB- in leukotriene B4 omega-oxidation .
8841133	0	aldehyde	65,73	isopeptidase_T	37,51	aldehyde	isopeptidase T	CHEBI:17478	8078	Chemical	Gene	studies|nmod|START_ENTITY studies|nmod|inhibition inhibition|nmod|END_ENTITY	Kinetic studies on the inhibition of isopeptidase_T by ubiquitin aldehyde .
1527093	0	aldehyde	80,88	methylmalonate-semialdehyde_dehydrogenase	14,55	aldehyde	methylmalonate-semialdehyde dehydrogenase	CHEBI:17478	4329	Chemical	Gene	superfamily|amod|START_ENTITY member|nmod|superfamily END_ENTITY|appos|member	CoA-dependent methylmalonate-semialdehyde_dehydrogenase , a unique member of the aldehyde dehydrogenase superfamily .
10744670	0	aldehyde	32,40	myeloperoxidase	54,69	aldehyde	myeloperoxidase	CHEBI:17478	4353	Chemical	Gene	START_ENTITY|acl|generated generated|nmod|END_ENTITY	p-hydroxyphenylacetaldehyde , an aldehyde generated by myeloperoxidase , modifies phospholipid amino groups of low density lipoprotein in human atherosclerotic intima .
11104675	0	aldehyde	84,92	myeloperoxidase	106,121	aldehyde	myeloperoxidase	CHEBI:17478	4353	Chemical	Gene	START_ENTITY|acl|generated generated|nmod|END_ENTITY	Elevated levels of protein-bound p-hydroxyphenylacetaldehyde , an amino-acid-derived aldehyde generated by myeloperoxidase , are present in human fatty_streaks , intermediate lesions and advanced atherosclerotic_lesions .
24075747	0	aldehydes	54,63	Akt	0,3	aldehydes	Akt	MESH:D000447	207	Chemical	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Akt and ERK/Nrf2 activation by PUFA oxidation-derived aldehydes upregulates FABP4 expression in human macrophages .
1686118	0	aldehydes	19,28	C-9	15,18	aldehydes	C-9	MESH:D000447	735	Chemical	Gene	START_ENTITY|nsubj|Interaction Interaction|nmod|END_ENTITY	Interaction of C-9 aldehydes with microtubular protein in vitro and in cultured cells in the presence of taxol .
16087478	0	aldehydes	11,20	CD36	24,28	aldehydes	CD36	MESH:D000447	948	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of aldehydes on CD36 expression .
13602804	0	aldehydes	34,43	growth_hormone	10,24	aldehydes	growth hormone	MESH:D000447	81668(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of growth_hormone on lipid aldehydes .
10856427	0	aldophosphamide	16,31	aldehyde_dehydrogenase_isozyme_3	41,73	aldophosphamide	aldehyde dehydrogenase isozyme 3	MESH:C006446	218	Chemical	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of aldophosphamide by human aldehyde_dehydrogenase_isozyme_3 .
14582038	0	aldose	86,92	AKR1B1	23,29	aldose	AKR1B1	CHEBI:15693	231	Chemical	Gene	content|amod|START_ENTITY associated|nmod|content associated|nsubjpass|polymorphism polymorphism|nmod|END_ENTITY	C-106T polymorphism of AKR1B1 is associated with diabetic_nephropathy and erythrocyte aldose reductase content in Japanese subjects with type_2_diabetes_mellitus .
15181092	0	aldose	65,71	AKR1B1	83,89	aldose	AKR1B1	CHEBI:15693	231	Chemical	Gene	reductase|compound|START_ENTITY reductase|appos|END_ENTITY	Decreased expression of cyclic_adenosine_monophosphate-regulated aldose reductase -LRB- AKR1B1 -RRB- is associated with malignancy_in_human_sporadic_adrenocortical_tumors .
16176189	0	aldose	19,25	AKR1B1	42,48	aldose	AKR1B1	CHEBI:15693	231	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The association of aldose reductase gene -LRB- AKR1B1 -RRB- polymorphisms with diabetic_neuropathy in adolescents .
16620264	0	aldose	30,36	AKR1B1	48,54	aldose	AKR1B1	CHEBI:15693	231	Chemical	Gene	START_ENTITY|dobj|reductase reductase|appos|END_ENTITY	Variants in the gene encoding aldose reductase -LRB- AKR1B1 -RRB- and diabetic_nephropathy in American Indians .
18165015	0	aldose	67,73	AKR1C21	55,62	aldose	AKR1C21	CHEBI:15693	77337(Tax:10090)	Chemical	Gene	inhibitors|amod|START_ENTITY END_ENTITY|nmod|inhibitors	Inhibition of 3 -LRB- 17 -RRB- alpha-hydroxysteroid_dehydrogenase -LRB- AKR1C21 -RRB- by aldose reductase inhibitors .
11032718	0	aldose	14,20	Akr1b1	37,43	aldose	Akr1b1	CHEBI:15693	11677(Tax:10090)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Disruption of aldose reductase gene -LRB- Akr1b1 -RRB- causes defect in urinary concentrating ability and divalent cation homeostasis .
3143793	0	aldose	13,19	CT-112	41,47	aldose	CT-112	CHEBI:15693	884032(Tax:272561)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Effect of an aldose reductase inhibitor , CT-112 , on healing of the corneal epithelium in galactose-fed rats .
23398717	0	aldose	100,106	GRE3	118,122	aldose	GRE3	CHEBI:15693	856504(Tax:4932)	Chemical	Gene	START_ENTITY|dobj|reductase reductase|appos|END_ENTITY	Feasibility of xylose fermentation by engineered Saccharomyces_cerevisiae overexpressing endogenous aldose reductase -LRB- GRE3 -RRB- , xylitol dehydrogenase -LRB- XYL2 -RRB- , and xylulokinase -LRB- XYL3 -RRB- from Scheffersomyces_stipitis .
18588981	0	aldose	32,38	Nrf2	0,4	aldose	Nrf2	CHEBI:15693	4780	Chemical	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Nrf2 regulates curcumin-induced aldose reductase expression indirectly via nuclear_factor-kappaB .
22951256	0	aldose	54,60	Nrf2	89,93	aldose	Nrf2	CHEBI:15693	4780	Chemical	Gene	START_ENTITY|nmod|pathway pathway|amod|END_ENTITY	Regulation of transforming growth factor b1-dependent aldose reductase expression by the Nrf2 signal pathway in human mesangial cells .
7490513	0	aldose	3,9	TAT	31,34	aldose	TAT	CHEBI:15693	24813(Tax:10116)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	An aldose reductase inhibitor , TAT , reduces ADP-induced platelet_hyperaggregation in streptozotocin-induced diabetic rats with neuropathy .
1443170	0	aldose	11,17	aldehyde_reductase	32,50	aldose	aldehyde reductase	CHEBI:15693	116463(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|production production|amod|END_ENTITY	Rat kidney aldose reductase and aldehyde_reductase and polyol production in rat kidney .
2117925	0	aldose	36,42	aldehyde_reductase	14,32	aldose	aldehyde reductase	CHEBI:15693	116463(Tax:10116)	Chemical	Gene	inhibitors|amod|START_ENTITY Inhibition|nmod|inhibitors Inhibition|nmod|END_ENTITY	Inhibition of aldehyde_reductase by aldose reductase inhibitors .
18588981	0	aldose	32,38	nuclear_factor-kappaB	75,96	aldose	nuclear factor-kappaB	CHEBI:15693	4790	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Nrf2 regulates curcumin-induced aldose reductase expression indirectly via nuclear_factor-kappaB .
9607806	0	aldosterone	81,92	11beta-hydroxysteroid_dehydrogenase-2	40,77	aldosterone	11beta-hydroxysteroid dehydrogenase-2	MESH:D000450	100009531(Tax:9986)	Chemical	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	Extranuclear localization of endogenous 11beta-hydroxysteroid_dehydrogenase-2 in aldosterone target cells .
16233969	0	aldosterone	10,21	ACTH	67,71	aldosterone	ACTH	MESH:D000450	403659(Tax:9615)	Chemical	Gene	concentrations|amod|START_ENTITY concentrations|compound|END_ENTITY	Cortisol , aldosterone , cortisol precursor , androgen and endogenous ACTH concentrations in dogs with pituitary-dependant hyperadrenocorticism treated with trilostane .
182890	0	aldosterone	44,55	ACTH	12,16	aldosterone	ACTH	MESH:D000450	5443	Chemical	Gene	release|nmod|START_ENTITY role|nmod|release role|nmod|END_ENTITY	The role of ACTH in the episodic release of aldosterone in patients with idiopathic adrenal_hyperplasia , hypertension , and hyperaldosteronism .
2993373	0	aldosterone	16,27	ACTH	58,62	aldosterone	ACTH	MESH:D000450	5443	Chemical	Gene	responses|compound|START_ENTITY responses|nmod|END_ENTITY	Biphasic plasma aldosterone responses to four single-dose ACTH regimens .
7794575	0	aldosterone	15,26	ACTH	30,34	aldosterone	ACTH	MESH:D000450	5443	Chemical	Gene	Stimulation|nmod|START_ENTITY Stimulation|nmod|END_ENTITY	Stimulation of aldosterone by ACTH in normal and hypertensive pregnancy .
1317269	0	aldosterone	28,39	ANF	12,15	aldosterone	ANF	MESH:D000450	4878	Chemical	Gene	secretion|amod|START_ENTITY Effects|nmod|secretion Effects|nmod|END_ENTITY	-LSB- Effects of ANF and ACTH on aldosterone secretion in cultured human adrenal tissue -RSB- .
20511409	0	aldosterone	99,110	ANG_II	73,79	aldosterone	ANG II	MESH:D000450	24179(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Central neuronal activation and pressor responses induced by circulating ANG_II : role of the brain aldosterone - `` ouabain '' pathway .
9553752	0	aldosterone	112,123	AT1	90,93	aldosterone	AT1	MESH:D000450	24180(Tax:10116)	Chemical	Gene	action|amod|START_ENTITY action|compound|END_ENTITY	The AT2 receptor-mediated stimulation of adrenal catecholamine release may potentiate the AT1 receptor-mediated aldosterone secretagogue action of angiotensin-II in rats .
10678544	0	aldosterone	59,70	Adrenomedullin	0,14	aldosterone	Adrenomedullin	MESH:D000450	133	Chemical	Gene	secretion|compound|START_ENTITY inhibits|dobj|secretion inhibits|nsubj|END_ENTITY	Adrenomedullin selectively inhibits angiotensin_II-induced aldosterone secretion in humans .
15361760	0	aldosterone	64,75	Aldosterone_synthase	0,20	aldosterone	Aldosterone synthase	MESH:D000450	1585	Chemical	Gene	activity|amod|START_ENTITY plasma|dobj|activity plasma|nsubj|gene gene|amod|END_ENTITY	Aldosterone_synthase gene -LRB- CYP11B2 -RRB- C-344T polymorphism , plasma aldosterone , renin activity and blood pressure in a multi-ethnic population .
1311245	0	aldosterone	110,121	Angiotensin-II	0,14	aldosterone	Angiotensin-II	MESH:D000450	24179(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY stimulation|nmod|production contribution|nmod|stimulation cells|dep|contribution pump|nmod|cells +|parataxis|pump +|compound|END_ENTITY	Angiotensin-II inhibits Na + / K + pump in rat adrenal glomerulosa cells : possible contribution to stimulation of aldosterone production .
11564720	0	aldosterone	277,288	Angiotensin_II	0,14	aldosterone	Angiotensin II	MESH:D000450	183	Chemical	Gene	biosynthesis|amod|START_ENTITY regulators|nmod|biosynthesis one|nmod|regulators class|acl:relcl|one induction|nmod|class promotes|nmod|induction promotes|nsubj|END_ENTITY	Angiotensin_II promotes selective uptake of high density lipoprotein cholesterol_esters in bovine adrenal glomerulosa and human adrenocortical_carcinoma cells through induction of scavenger receptor class B type I. Angiotensin_II is one of the main physiological regulators of aldosterone biosynthesis in the zona glomerulosa of the adrenal cortex .
1554376	0	aldosterone	36,47	Angiotensin_II	0,14	aldosterone	Angiotensin II	MESH:D000450	24179(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY exerts|nmod|production exerts|nsubj|END_ENTITY	Angiotensin_II exerts its effect on aldosterone production and potassium permeability through receptor subtype AT1 in rat adrenal glomerulosa cells .
20720527	0	aldosterone	110,121	Angiotensin_II	0,14	aldosterone	Angiotensin II	MESH:D000450	24179(Tax:10116)	Chemical	Gene	independent|nmod|START_ENTITY phosphorylation|nmod|independent induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Angiotensin_II induces phosphorylation of the thiazide-sensitive sodium_chloride cotransporter independent of aldosterone .
22086923	0	aldosterone	103,114	Angiotensin_II	0,14	aldosterone	Angiotensin II	MESH:D000450	11606(Tax:10090)	Chemical	Gene	increases|xcomp|START_ENTITY increases|nsubj|END_ENTITY	Angiotensin_II increases activity of the epithelial Na + channel -LRB- ENaC -RRB- in distal nephron additively to aldosterone .
4363578	0	aldosterone	42,53	Angiotensin_II	0,14	aldosterone	Angiotensin II	MESH:D000450	24179(Tax:10116)	Chemical	Gene	vivo|amod|START_ENTITY END_ENTITY|dep|vivo	Angiotensin_II - and angiotensin 3-induced aldosterone release vivo in the rat .
7014601	0	aldosterone	59,70	Angiotensin_II	0,14	aldosterone	Angiotensin II	MESH:D000450	183	Chemical	Gene	regulating|dobj|START_ENTITY potent|advcl|regulating potent|nsubj|END_ENTITY	Angiotensin_II is more potent than potassium in regulating aldosterone in cardiac_failure : evidence during captopril therapy .
1832287	0	aldosterone	61,72	Atrial_natriuretic_factor	0,25	aldosterone	Atrial natriuretic factor	MESH:D000450	4878	Chemical	Gene	release|amod|START_ENTITY stimulated|dobj|release metoclopramide|acl|stimulated inhibits|dobj|metoclopramide inhibits|nsubj|END_ENTITY	Atrial_natriuretic_factor inhibits metoclopramide stimulated aldosterone release in man .
1965335	0	aldosterone	68,79	Atrial_natriuretic_factor	0,25	aldosterone	Atrial natriuretic factor	MESH:D000450	24602(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY involved|nmod|production unlikely|xcomp|involved unlikely|nsubj|END_ENTITY	Atrial_natriuretic_factor is unlikely to be involved in the reduced aldosterone production in the Brattleboro rat .
2538117	0	aldosterone	55,66	Atrial_natriuretic_factor	0,25	aldosterone	Atrial natriuretic factor	MESH:D000450	281355(Tax:9913)	Chemical	Gene	secretion|compound|START_ENTITY inhibits|dobj|secretion inhibits|nsubj|END_ENTITY	Atrial_natriuretic_factor inhibits angiotensin-induced aldosterone secretion : not through cGMP or interference with phospholipase C. ANF did not prevent the formation of -LSB- 3H -RSB- _ inositol_trisphosphate in response to AII but inhibited aldosterone secretion in calf adrenal glomerulosa cells .
6092045	0	aldosterone	54,65	Atrial_natriuretic_factor	0,25	aldosterone	Atrial natriuretic factor	MESH:D000450	24602(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY stimulation|nmod|secretion inhibits|dobj|stimulation inhibits|nsubj|END_ENTITY	Atrial_natriuretic_factor inhibits the stimulation of aldosterone secretion by angiotensin_II , ACTH and potassium in vitro and angiotensin_II-induced steroidogenesis in vivo .
8467324	0	aldosterone	45,56	Atrial_natriuretic_factor	0,25	aldosterone	Atrial natriuretic factor	MESH:D000450	608289(Tax:9615)	Chemical	Gene	response|amod|START_ENTITY END_ENTITY|nmod|response	Atrial_natriuretic_factor and changes in the aldosterone response to angiotensin II in sodium depleted dogs .
1657569	0	aldosterone	77,88	Atrial_natriuretic_peptide	0,26	aldosterone	Atrial natriuretic peptide	MESH:D000450	24602(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|inhibition inhibition|amod|END_ENTITY	Atrial_natriuretic_peptide inhibition of calcium ionophore A23187-stimulated aldosterone secretion in rat adrenal glomerulosa cells .
2948755	0	aldosterone	86,97	Atrial_natriuretic_peptide	0,26	aldosterone	Atrial natriuretic peptide	MESH:D000450	24602(Tax:10116)	Chemical	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	Atrial_natriuretic_peptide inhibits the effect of endogenous angiotensin_II on plasma aldosterone in conscious sodium-depleted rats .
2964364	0	aldosterone	55,66	Atrial_natriuretic_peptide	0,26	aldosterone	Atrial natriuretic peptide	MESH:D000450	281355(Tax:9913)	Chemical	Gene	secretion|amod|START_ENTITY stimulation|nmod|secretion inhibits|dobj|stimulation inhibits|nsubj|END_ENTITY	Atrial_natriuretic_peptide inhibits the stimulation of aldosterone secretion but not the transient increase in intracellular free calcium concentration induced by angiotensin II addition .
3008159	0	aldosterone	55,66	Atrial_natriuretic_peptide	0,26	aldosterone	Atrial natriuretic peptide	MESH:D000450	24602(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY stimulation|nmod|secretion inhibits|dobj|stimulation inhibits|nsubj|END_ENTITY	Atrial_natriuretic_peptide inhibits the stimulation of aldosterone secretion by ACTH in vitro and in vivo .
18579708	0	aldosterone	10,21	BK_channel	25,35	aldosterone	BK channel	MESH:D000450	100008745(Tax:9986)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of aldosterone on BK_channel expression in mammalian cortical collecting duct .
1312440	0	aldosterone	22,33	Bradykinin	0,10	aldosterone	Bradykinin	MESH:D000450	280833(Tax:9913)	Chemical	Gene	release|amod|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Bradykinin stimulates aldosterone release from cultured bovine adrenocortical cells through bradykinin B2 receptors .
2836182	0	aldosterone	51,62	CRF	43,46	aldosterone	CRF	MESH:D000450	1392	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of corticotropin-releasing_factor -LRB- CRF -RRB- on aldosterone and 18-hydroxycorticosterone in essential_hypertension and primary_aldosteronism .
18171693	0	aldosterone	35,46	CTRP1	18,23	aldosterone	CTRP1	MESH:D000450	114897	Chemical	Gene	production|amod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	A novel adipokine CTRP1 stimulates aldosterone production .
11572038	0	aldosterone	20,31	CYP11B2	136,143	aldosterone	CYP11B2	MESH:D000450	1585	Chemical	Gene	release|nmod|START_ENTITY correlates|nsubj|release correlates|nmod|expression expression|nmod|enzymes enzymes|nmod|END_ENTITY	In vitro release of aldosterone and cortisol in human adrenal_adenomas correlates to mRNA expression of steroidogenic enzymes for genes CYP11B2 and CYP17 .
12788845	0	aldosterone	60,71	CYP11B2	33,40	aldosterone	CYP11B2	MESH:D000450	1585	Chemical	Gene	predicts|dobj|START_ENTITY predicts|nsubj|polymorphism polymorphism|nmod|END_ENTITY	A biallelic gene polymorphism of CYP11B2 predicts increased aldosterone to renin ratio in selected hypertensive patients .
1346492	0	aldosterone	23,34	CYP11B2	116,123	aldosterone	CYP11B2	MESH:D000450	1585	Chemical	Gene	biosynthesis|compound|START_ENTITY biosynthesis|dep|involvement involvement|nmod|mutations mutations|nmod|gene gene|appos|END_ENTITY	Congenitally defective aldosterone biosynthesis in humans : the involvement of point mutations of the P-450C18 gene -LRB- CYP11B2 -RRB- in CMO_II_deficient patients .
15361760	0	aldosterone	64,75	CYP11B2	27,34	aldosterone	CYP11B2	MESH:D000450	1585	Chemical	Gene	activity|amod|START_ENTITY plasma|dobj|activity plasma|nsubj|gene gene|appos|END_ENTITY	Aldosterone_synthase gene -LRB- CYP11B2 -RRB- C-344T polymorphism , plasma aldosterone , renin activity and blood pressure in a multi-ethnic population .
1775135	0	aldosterone	48,59	CYP11B2	19,26	aldosterone	CYP11B2	MESH:D000450	1585	Chemical	Gene	biosynthesis|amod|START_ENTITY required|nmod|biosynthesis required|nsubjpass|product product|nmod|gene gene|compound|END_ENTITY	The product of the CYP11B2 gene is required for aldosterone biosynthesis in the human adrenal cortex .
19622340	0	aldosterone	123,134	CYP11B2	16,23	aldosterone	CYP11B2	MESH:D000450	1585	Chemical	Gene	inhibitors|amod|START_ENTITY potency|nmod|inhibitors assessing|dobj|potency Coexpression|acl|assessing Coexpression|nmod|END_ENTITY	Coexpression of CYP11B2 or CYP11B1 with adrenodoxin_and_adrenodoxin_reductase for assessing the potency and selectivity of aldosterone synthase inhibitors .
20413672	0	aldosterone	48,59	CYP11B2	133,140	aldosterone	CYP11B2	MESH:D000450	1585	Chemical	Gene	synthesis|compound|START_ENTITY mediates|dobj|synthesis mediates|nmod|up-regulation up-regulation|nmod|transcription transcription|nmod|gene gene|compound|END_ENTITY	Calcineurin mediates the angiotensin_II-induced aldosterone synthesis in the adrenal glands by up-regulation of transcription of the CYP11B2 gene .
20598712	0	aldosterone	27,38	CYP11B2	49,56	aldosterone	CYP11B2	MESH:D000450	1585	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of the -344 C/T aldosterone synthase -LRB- CYP11B2 -RRB- gene variant with hypertension and stroke .
23936266	0	aldosterone	123,134	CYP11B2	50,57	aldosterone	CYP11B2	MESH:D000450	1585	Chemical	Gene	START_ENTITY|nsubj|Association Association|nmod|polymorphism polymorphism|appos|C C|compound|END_ENTITY	Association of aldosterone synthase polymorphism -LRB- CYP11B2 -344 T > C -RRB- and genetic ancestry with atrial_fibrillation and serum aldosterone in African Americans with heart_failure .
23936266	0	aldosterone	15,26	CYP11B2	50,57	aldosterone	CYP11B2	MESH:D000450	1585	Chemical	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|C C|compound|END_ENTITY	Association of aldosterone synthase polymorphism -LRB- CYP11B2 -344 T > C -RRB- and genetic ancestry with atrial_fibrillation and serum aldosterone in African Americans with heart_failure .
24388430	0	aldosterone	14,25	CYP11B2	46,53	aldosterone	CYP11B2	MESH:D000450	1585	Chemical	Gene	levels|amod|START_ENTITY Modulation|nmod|levels Modulation|nmod|polymorphism polymorphism|compound|END_ENTITY	Modulation of aldosterone levels by -344 __ C/T CYP11B2 polymorphism and spironolactone use in resistant hypertension .
8333830	0	aldosterone	69,80	CYP11B2	91,98	aldosterone	CYP11B2	MESH:D000450	24294(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY synthase|dep|variant variant|appos|END_ENTITY	Cloning and expression of a rat cytochrome_P-450_11_beta-hydroxylase / aldosterone synthase -LRB- CYP11B2 -RRB- cDNA variant .
8439335	0	aldosterone	23,34	CYP11B2	94,101	aldosterone	CYP11B2	MESH:D000450	1585	Chemical	Gene	biosynthesis|compound|START_ENTITY biosynthesis|dep|inactivation inactivation|nmod|gene gene|appos|END_ENTITY	Congenitally defective aldosterone biosynthesis in humans : inactivation of the P-450C18 gene -LRB- CYP11B2 -RRB- due to nucleotide deletion in CMO_I_deficient patients .
9303441	0	aldosterone	78,89	CYP11B2	32,39	aldosterone	CYP11B2	MESH:D000450	1585	Chemical	Gene	START_ENTITY|nsubj|Characterization Characterization|nmod|gene gene|compound|END_ENTITY	Characterization of the hamster CYP11B2 gene encoding adrenal cytochrome P450 aldosterone synthase .
11494052	0	aldosterone	104,115	Calcitonin_gene-related_peptide	0,31	aldosterone	Calcitonin gene-related peptide	MESH:D000450	24241(Tax:10116)	Chemical	Gene	secretion|compound|START_ENTITY inhibits|dobj|secretion inhibits|nsubj|END_ENTITY	Calcitonin_gene-related_peptide -LRB- CGRP -RRB- , acting via CGRP type 1 receptors , inhibits potassium-stimulated aldosterone secretion and enhances basal catecholamine secretion from rat adrenal gland .
15001623	0	aldosterone	33,44	Cholecystokinin	0,15	aldosterone	Cholecystokinin	MESH:D000450	885	Chemical	Gene	secretion|amod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Cholecystokinin -LRB- CCK -RRB- stimulates aldosterone secretion from human adrenocortical cells via CCK2 receptors coupled to the adenylate cyclase/protein kinase A signaling cascade .
19531903	0	aldosterone	11,22	Cx43	26,30	aldosterone	Cx43	MESH:D000450	24392(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effects of aldosterone on Cx43 gap junction expression in neonatal rat cultured cardiomyocytes .
16757729	11	aldosterone	1485,1496	ERK	1580,1583	aldosterone	ERK	MESH:D000450	24338(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|activation activation|nmod|END_ENTITY	These data demonstrate that aldosterone inhibits NHE3 and HCO -LRB- 3 -RRB- -LRB- - -RRB- absorption in the MTAL through rapid activation of the ERK signaling pathway .
10979239	0	aldosterone	24,35	Endothelin-1	0,12	aldosterone	Endothelin-1	MESH:D000450	1906	Chemical	Gene	synthesis|amod|START_ENTITY stimulates|dobj|synthesis stimulates|nsubj|END_ENTITY	Endothelin-1 stimulates aldosterone synthesis in Conn 's adenomas via both A and B receptors coupled with the protein kinase C - and cyclooxygenase-dependent signaling pathways .
1310239	0	aldosterone	59,70	Endothelin-1	0,12	aldosterone	Endothelin-1	MESH:D000450	281137(Tax:9913)	Chemical	Gene	production|amod|START_ENTITY potentiation|nmod|production potentiation|amod|END_ENTITY	Endothelin-1 potentiation of angiotensin II stimulation of aldosterone production .
8049132	0	aldosterone	28,39	Endothelin-1	0,12	aldosterone	Endothelin-1	MESH:D000450	24323(Tax:10116)	Chemical	Gene	glomerulosa|compound|START_ENTITY stimulation|nmod|glomerulosa stimulation|amod|END_ENTITY	Endothelin-1 stimulation of aldosterone and zona glomerulosa ouabain-sensitive sodium/potassium-ATPase .
9057014	0	aldosterone	53,64	Endothelin-1	0,12	aldosterone	Endothelin-1	MESH:D000450	24323(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY stimulate|dobj|secretion receptors|acl|stimulate acts|nmod|receptors acts|nsubj|END_ENTITY	Endothelin-1 acts through ETA receptors to stimulate aldosterone secretion by the rat adrenal gland .
26646587	0	aldosterone	47,58	GPER	0,4	aldosterone	GPER	MESH:D000450	2852	Chemical	Gene	effects|nmod|START_ENTITY involved|nmod|effects involved|nsubjpass|END_ENTITY	GPER is involved in the stimulatory effects of aldosterone in breast_cancer cells and breast_tumor-derived endothelial cells .
21354648	0	aldosterone	72,83	Glucocorticoid_receptor	0,23	aldosterone	Glucocorticoid receptor	MESH:D000450	2908	Chemical	Gene	indispensable|xcomp|START_ENTITY indispensable|nsubj|END_ENTITY	Glucocorticoid_receptor is indispensable for physiological responses to aldosterone in epithelial Na + channel induction via the mineralocorticoid receptor in a human colonic cell line .
23484111	0	aldosterone	27,38	Hsp90	65,70	aldosterone	Hsp90	MESH:D000450	299331(Tax:10116)	Chemical	Gene	action|nmod|START_ENTITY action|nmod|END_ENTITY	Rapid nongenomic action of aldosterone on protein expressions of Hsp90 -LRB- a and b -RRB- and pc-Src in rat kidney .
22328165	0	aldosterone	61,72	IGF-I	15,20	aldosterone	IGF-I	MESH:D000450	3479	Chemical	Gene	START_ENTITY|nsubj|Association Association|nmod|END_ENTITY	Association of IGF-I and the IGF-I/IGFBP -3 ratio with plasma aldosterone levels in the general population .
18089602	0	aldosterone	20,31	Metastin	0,8	aldosterone	Metastin	MESH:D000450	3814	Chemical	Gene	synthesis|amod|START_ENTITY stimulates|dobj|synthesis stimulates|nsubj|END_ENTITY	Metastin stimulates aldosterone synthesis in human adrenal cells .
16251474	0	aldosterone	25,36	NHE3	55,59	aldosterone	NHE3	MESH:D000450	24784(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|Na Na|compound|END_ENTITY	Nongenomic regulation by aldosterone of the epithelial NHE3 Na -LRB- + -RRB- / H -LRB- + -RRB- exchanger .
21292834	0	aldosterone	22,33	NOX-4	62,67	aldosterone	NOX-4	MESH:D000450	85431(Tax:10116)	Chemical	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	Eplerenone suppresses aldosterone / salt-induced expression of NOX-4 .
1650705	0	aldosterone	79,90	Neurotensin	0,11	aldosterone	Neurotensin	MESH:D000450	299757(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY effect|nmod|secretion inhibits|dobj|effect inhibits|nsubj|END_ENTITY	Neurotensin inhibits the stimulatory effect of angiotensin-II and potassium on aldosterone secretion by rat zona glomerulosa cells .
1730695	1	aldosterone	141,152	P-450scc	109,117	aldosterone	P-450scc	MESH:D000450	338048(Tax:9913)	Chemical	Gene	specificity|nmod|START_ENTITY END_ENTITY|nmod|specificity	Implication of P-450scc in zone specificity of aldosterone biosynthesis in bovine adrenal .
1360010	0	aldosterone	42,53	P-glycoprotein	6,20	aldosterone	P-glycoprotein	MESH:D000450	5243	Chemical	Gene	transports|dobj|START_ENTITY transports|nsubj|END_ENTITY	Human P-glycoprotein transports cortisol , aldosterone , and dexamethasone , but not progesterone .
15070972	0	aldosterone	10,21	PAI-1	75,80	aldosterone	PAI-1	MESH:D000450	5054	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effect of aldosterone and glycyrrhetinic_acid on the protein expression of PAI-1 and p22 -LRB- phox -RRB- in human mononuclear leukocytes .
25663965	0	aldosterone	10,21	PAI-1	62,67	aldosterone	PAI-1	MESH:D000450	24617(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	Effect of aldosterone and its antagonist on the expression of PAI-1 and TGF-b1 in rat hepatic stellate cells .
23541637	6	aldosterone	1043,1054	PKD1	1086,1090	aldosterone	PKD1	MESH:D000450	5587	Chemical	Gene	induced|nsubj|START_ENTITY induced|dobj|interaction interaction|nmod|END_ENTITY	PKD1 and PI4KIIIb localize to the TGN , and aldosterone induced an interaction between PKD1 and PI4KIIIb following aldosterone treatment .
20219982	0	aldosterone	32,43	Phospholipase_D2	0,16	aldosterone	Phospholipase D2	MESH:D000450	522159(Tax:9913)	Chemical	Gene	secretion|compound|START_ENTITY mediates|dobj|secretion mediates|nsubj|END_ENTITY	Phospholipase_D2 mediates acute aldosterone secretion in response to angiotensin II in adrenal glomerulosa cells .
9435451	0	aldosterone	49,60	Proadrenomedullin_N-terminal_20_peptide	0,39	aldosterone	Proadrenomedullin N-terminal 20 peptide	MESH:D000450	133	Chemical	Gene	secretion|amod|START_ENTITY inhibits|dobj|secretion inhibits|nsubj|END_ENTITY	Proadrenomedullin_N-terminal_20_peptide inhibits aldosterone secretion of human adrenocortical and Conn 's adenoma cells : comparison with adrenomedullin effect .
23964068	0	aldosterone	13,24	QRFP	0,4	aldosterone	QRFP	MESH:D000450	347148	Chemical	Gene	production|amod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	QRFP induces aldosterone production via PKC and T-type calcium channel-mediated pathways in human adrenocortical cells : evidence for a novel role of GPR103 .
10928619	0	aldosterone	18,29	Renin	0,5	aldosterone	Renin	MESH:D000450	5972	Chemical	Gene	system|compound|START_ENTITY system|compound|END_ENTITY	Renin angiotensin aldosterone system and drug_allergies complicated with hypotension .
12449448	0	aldosterone	18,29	Renin	0,5	aldosterone	Renin	MESH:D000450	5972	Chemical	Gene	modulation|amod|START_ENTITY angiotensin|dobj|modulation angiotensin|nsubj|END_ENTITY	Renin angiotensin aldosterone and adrenergic modulation in chronic heart_failure : contemporary concepts .
15047641	0	aldosterone	18,29	Renin	0,5	aldosterone	Renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|nsubj|angiotensin angiotensin|compound|END_ENTITY	Renin angiotensin aldosterone system blockade and renal_disease in patients with type 2 diabetes .
15558999	0	aldosterone	18,29	Renin	0,5	aldosterone	Renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|nsubj|angiotensin angiotensin|compound|END_ENTITY	Renin angiotensin aldosterone system and ACE I/D gene polymorphism in high-altitude pulmonary_edema .
17009077	0	aldosterone	18,29	Renin	0,5	aldosterone	Renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|nsubj|angiotensin angiotensin|compound|END_ENTITY	Renin angiotensin aldosterone system blockade and renal_disease in patients with type 2 diabetes : a subanalysis of Japanese patients from the RENAAL study .
19820005	0	aldosterone	44,55	Renin	56,61	aldosterone	Renin	MESH:D000450	5972	Chemical	Gene	ratio|amod|START_ENTITY ratio|compound|END_ENTITY	Familial and phenotypic associations of the aldosterone Renin ratio .
22396488	0	aldosterone	44,55	Renin	0,5	aldosterone	Renin	MESH:D000450	5972	Chemical	Gene	synthesis|amod|START_ENTITY effect|nmod|synthesis have|dobj|effect have|nsubj|END_ENTITY	Renin and prorenin have no direct effect on aldosterone synthesis in the human adrenocortical cell lines H295R and HAC15 .
22783584	0	aldosterone	18,29	Renin	0,5	aldosterone	Renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|nsubj|angiotensin angiotensin|compound|END_ENTITY	Renin angiotensin aldosterone system and glycemia in pregnancy .
25394830	0	aldosterone	39,50	Renin	0,5	aldosterone	Renin	MESH:D000450	24715(Tax:10116)	Chemical	Gene	control|nmod|START_ENTITY rat|dep|control rat|compound|END_ENTITY	Renin knockout rat : control of adrenal aldosterone and corticosterone synthesis in vitro and adrenal gene expression .
26936907	0	aldosterone	43,54	Renin	25,30	aldosterone	Renin	MESH:D000450	5972	Chemical	Gene	prevention|compound|START_ENTITY prevention|compound|END_ENTITY	Proteomic prediction and Renin angiotensin aldosterone system Inhibition prevention Of early diabetic_nephRopathy in TYpe 2 diabetic patients with normoalbuminuria -LRB- PRIORITY -RRB- : essential study design and rationale of a randomised clinical multicentre trial .
3625756	0	aldosterone	18,29	Renin	0,5	aldosterone	Renin	MESH:D000450	469651(Tax:9598)	Chemical	Gene	START_ENTITY|nsubj|angiotensin angiotensin|compound|END_ENTITY	Renin angiotensin aldosterone axis , including aldosterone binding globulin and blood pressure in three species of nonhuman primates .
3625756	0	aldosterone	46,57	Renin	0,5	aldosterone	Renin	MESH:D000450	469651(Tax:9598)	Chemical	Gene	globulin|compound|START_ENTITY axis|nmod|globulin aldosterone|dobj|axis aldosterone|nsubj|angiotensin angiotensin|compound|END_ENTITY	Renin angiotensin aldosterone axis , including aldosterone binding globulin and blood pressure in three species of nonhuman primates .
6762265	0	aldosterone	18,29	Renin	0,5	aldosterone	Renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|nsubj|angiotensin angiotensin|compound|END_ENTITY	Renin angiotensin aldosterone system and adrenergic system in normotensive and hypertensive pregnancy .
7902711	0	aldosterone	40,51	Renin	0,5	aldosterone	Renin	MESH:D000450	5972	Chemical	Gene	responsiveness|amod|START_ENTITY associated|nmod|responsiveness associated|nsubj|polymorphism polymorphism|compound|END_ENTITY	Renin gene polymorphism associated with aldosterone responsiveness to the renin-angiotensin system in patients with aldosterone-producing adenomas .
7915644	0	aldosterone	40,51	Renin	0,5	aldosterone	Renin	MESH:D000450	5972	Chemical	Gene	responsiveness|amod|START_ENTITY associated|nmod|responsiveness associated|nsubj|polymorphism polymorphism|compound|END_ENTITY	Renin gene polymorphism associated with aldosterone responsiveness to the renin-angiotensin system in patients with aldosterone-producing adenomas .
19878209	0	aldosterone	21,32	TASK1	12,17	aldosterone	TASK1	MESH:D000450	3777	Chemical	Gene	production|amod|START_ENTITY role|nmod|production role|nmod|END_ENTITY	The role of TASK1 in aldosterone production and its expression in normal adrenal and aldosterone-producing adenomas .
8440178	0	aldosterone	43,54	Transforming_growth_factor-beta_1	0,33	aldosterone	Transforming growth factor-beta 1	MESH:D000450	282089(Tax:9913)	Chemical	Gene	biosynthesis|amod|START_ENTITY inhibits|dobj|biosynthesis inhibits|nsubj|END_ENTITY	Transforming_growth_factor-beta_1 inhibits aldosterone biosynthesis in cultured bovine zona glomerulosa cells .
12525251	0	aldosterone	42,53	Transforming_growth_factor_beta1	0,32	aldosterone	Transforming growth factor beta1	MESH:D000450	7040	Chemical	Gene	production|amod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Transforming_growth_factor_beta1 inhibits aldosterone and cortisol production in the human adrenocortical cell line NCI-H295R through inhibition of CYP11B1 and CYP11B2 expression .
22549224	0	aldosterone	98,109	acyl-CoA_synthetase_4	48,69	aldosterone	acyl-CoA synthetase 4	MESH:D000450	2182	Chemical	Gene	synthesis|compound|START_ENTITY END_ENTITY|nmod|synthesis	Role of intramitochondrial arachidonic_acid and acyl-CoA_synthetase_4 in angiotensin_II-regulated aldosterone synthesis in NCI-H295R adrenocortical cell line .
15969251	0	aldosterone	30,41	adrenocorticotropic_hormone	54,81	aldosterone	adrenocorticotropic hormone	MESH:D000450	5443	Chemical	Gene	response|amod|START_ENTITY response|nmod|END_ENTITY	Relationship between impaired aldosterone response to adrenocorticotropic_hormone and prevalence of hemodialysis in type 2 diabetic patients without azotemia .
2177115	0	aldosterone	91,102	adrenocorticotropic_hormone	40,67	aldosterone	adrenocorticotropic hormone	MESH:D000450	5443	Chemical	Gene	independent|amod|START_ENTITY decrease|nmod|independent role|nmod|decrease Hyponatremia|dep|role Hyponatremia|nmod|isolated_deficiency isolated_deficiency|nmod|END_ENTITY	-LSB- Hyponatremia in isolated_deficiency of adrenocorticotropic_hormone : role of a decrease in aldosterone secretion independent of antidiuretic_hormone excess -RSB- .
15361767	0	aldosterone	77,88	adrenomedullin	11,25	aldosterone	adrenomedullin	MESH:D000450	25026(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Effects Effects|nmod|END_ENTITY	Effects of adrenomedullin on cell proliferation in rat adventitia induced by aldosterone .
9877221	0	aldosterone	49,60	adrenomedullin	21,35	aldosterone	adrenomedullin	MESH:D000450	133	Chemical	Gene	response|amod|START_ENTITY END_ENTITY|nmod|response	Inhibitory effect of adrenomedullin -LRB- ADM -RRB- on the aldosterone response of human adrenocortical cells to angiotensin-II : role of ADM -LRB- 22-52 -RRB- - sensitive receptors .
16796847	0	aldosterone	75,86	aldosterone_synthase	16,36	aldosterone	aldosterone synthase	MESH:D000450	1585	Chemical	Gene	polymorphism|nmod|START_ENTITY polymorphism|compound|END_ENTITY	-LSB- Association of aldosterone_synthase gene -344 T/C polymorphism with plasma aldosterone and angiotensin_II concentration in hypertensive patients -RSB- .
19427380	0	aldosterone	49,60	aldosterone_synthase	10,30	aldosterone	aldosterone synthase	MESH:D000450	24294(Tax:10116)	Chemical	Gene	formation|amod|START_ENTITY reduce|dobj|formation reduce|nsubj|inhibitors inhibitors|compound|END_ENTITY	Selective aldosterone_synthase inhibitors reduce aldosterone formation in vitro and in vivo .
22184340	0	aldosterone	26,37	aldosterone_synthase	86,106	aldosterone	aldosterone synthase	MESH:D000450	1585	Chemical	Gene	synthesis|amod|START_ENTITY synthesis|nmod|result result|nmod|cleavage cleavage|nmod|END_ENTITY	Alteration in accumulated aldosterone synthesis as a result of N-terminal cleavage of aldosterone_synthase .
22947355	0	aldosterone	50,61	aldosterone_synthase	15,35	aldosterone	aldosterone synthase	MESH:D000450	1585	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	The effects of aldosterone_synthase inhibition on aldosterone and cortisol in patients with hypertension : a phase II , randomized , double-blind , placebo-controlled , multicenter study .
9360501	0	aldosterone	37,48	aldosterone_synthase	50,70	aldosterone	aldosterone synthase	MESH:D000450	1585	Chemical	Gene	biosynthesis|nmod|START_ENTITY Hereditary_defect|nmod|biosynthesis Hereditary_defect|dep|deficiency deficiency|amod|END_ENTITY	Hereditary_defect in biosynthesis of aldosterone : aldosterone_synthase deficiency 1964-1997 .
4376741	0	aldosterone	54,65	alpha-melanocyte_stimulating_hormone	14,50	aldosterone	alpha-melanocyte stimulating hormone	MESH:D000450	24664(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY effect|nmod|production effect|nmod|END_ENTITY	The effect of alpha-melanocyte_stimulating_hormone on aldosterone production in the rat .
1650705	0	aldosterone	79,90	angiotensin-II	47,61	aldosterone	angiotensin-II	MESH:D000450	24179(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY effect|nmod|secretion effect|nmod|END_ENTITY	Neurotensin inhibits the stimulatory effect of angiotensin-II and potassium on aldosterone secretion by rat zona glomerulosa cells .
2547581	0	aldosterone	30,41	angiotensin-II	128,142	aldosterone	angiotensin-II	MESH:D000450	24179(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY modulation|nmod|secretion modulation|dep|impact impact|acl|converting converting|nmod|END_ENTITY	Sodium-mediated modulation of aldosterone secretion : impact of converting enzyme inhibition on rat glomerulosa cell response to angiotensin-II .
945156	0	aldosterone	138,149	angiotensin-II	153,167	aldosterone	angiotensin-II	MESH:D000450	183	Chemical	Gene	responsiveness|nmod|START_ENTITY growth_hormone|dobj|responsiveness growth_hormone|advcl|END_ENTITY	The diurnal rhythm of plasma aldosterone , plasma renin activity , plasma cortisol and serum growth_hormone and subnormal responsiveness of aldosterone to angiotensin-II in the patients with normotensive acromegaly .
945156	0	aldosterone	29,40	angiotensin-II	153,167	aldosterone	angiotensin-II	MESH:D000450	183	Chemical	Gene	rhythm|nmod|START_ENTITY growth_hormone|nsubj|rhythm growth_hormone|advcl|END_ENTITY	The diurnal rhythm of plasma aldosterone , plasma renin activity , plasma cortisol and serum growth_hormone and subnormal responsiveness of aldosterone to angiotensin-II in the patients with normotensive acromegaly .
9553752	0	aldosterone	112,123	angiotensin-II	147,161	aldosterone	angiotensin-II	MESH:D000450	24179(Tax:10116)	Chemical	Gene	action|amod|START_ENTITY action|nmod|END_ENTITY	The AT2 receptor-mediated stimulation of adrenal catecholamine release may potentiate the AT1 receptor-mediated aldosterone secretagogue action of angiotensin-II in rats .
9877221	0	aldosterone	49,60	angiotensin-II	103,117	aldosterone	angiotensin-II	MESH:D000450	183	Chemical	Gene	response|amod|START_ENTITY response|nmod|cells cells|nmod|END_ENTITY	Inhibitory effect of adrenomedullin -LRB- ADM -RRB- on the aldosterone response of human adrenocortical cells to angiotensin-II : role of ADM -LRB- 22-52 -RRB- - sensitive receptors .
12196328	0	aldosterone	16,27	angiotensin-converting_enzyme	79,108	aldosterone	angiotensin-converting enzyme	MESH:D000450	1636	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Elevated plasma aldosterone levels despite complete inhibition of the vascular angiotensin-converting_enzyme in chronic_heart_failure .
1019166	0	aldosterone	84,95	angiotensin_II	140,154	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	START_ENTITY|nmod|concentration concentration|compound|END_ENTITY	The effects of the angiotensin_II antagonist saralasin on blood pressure and plasma aldosterone in man in relation to the prevailing plasma angiotensin_II concentration .
1019166	0	aldosterone	84,95	angiotensin_II	19,33	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|saralasin saralasin|amod|END_ENTITY	The effects of the angiotensin_II antagonist saralasin on blood pressure and plasma aldosterone in man in relation to the prevailing plasma angiotensin_II concentration .
10338465	0	aldosterone	22,33	angiotensin_II	85,99	aldosterone	angiotensin II	MESH:D000450	24179(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY Activation|nmod|production Activation|dep|effect effect|nmod|blockade blockade|compound|END_ENTITY	Activation of cardiac aldosterone production in rat myocardial_infarction : effect of angiotensin_II receptor blockade and role in cardiac fibrosis .
11325526	0	aldosterone	93,104	angiotensin_II	60,74	aldosterone	angiotensin II	MESH:D000450	24179(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY stimulated|dobj|secretion stimulated|nsubj|Role Role|nmod|depolarization depolarization|nmod|END_ENTITY	Role of membrane depolarization and T-type Ca2 + channels in angiotensin_II and K + stimulated aldosterone secretion .
11948018	0	aldosterone	82,93	angiotensin_II	22,36	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	secretion|compound|START_ENTITY secretion|compound|adrenocorticotropin adrenocorticotropin|compound|END_ENTITY	Okadaic_acid inhibits angiotensin_II , adrenocorticotropin and potassium-dependent aldosterone secretion .
12446610	0	aldosterone	10,21	angiotensin_II	40,54	aldosterone	angiotensin II	MESH:D000450	24179(Tax:10116)	Chemical	Gene	blockade|compound|START_ENTITY prevents|nsubj|blockade prevents|dobj|vascular_inflammation vascular_inflammation|amod|END_ENTITY	Selective aldosterone blockade prevents angiotensin_II / salt-induced vascular_inflammation in the rat heart .
1422075	0	aldosterone	34,45	angiotensin_II	47,61	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	peptide|appos|START_ENTITY END_ENTITY|nsubj|peptide	Atrial natriuretic peptide -LRB- ANP -RRB- , aldosterone , angiotensin_II and renin in the ` low_T3_syndrome ' in organ donors .
15134809	0	aldosterone	56,67	angiotensin_II	15,29	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	biosynthesis|amod|START_ENTITY supply|nmod|biosynthesis supply|nsubj|control control|nmod|END_ENTITY	The control by angiotensin_II of cholesterol supply for aldosterone biosynthesis .
16144984	0	aldosterone	22,33	angiotensin_II	71,85	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|interaction interaction|nmod|END_ENTITY	Nongenomic effects of aldosterone in the human heart : interaction with angiotensin_II .
1652115	0	aldosterone	99,110	angiotensin_II	83,97	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	prostaglandin_E2|dep|START_ENTITY prostaglandin_E2|dep|END_ENTITY	Effect of frusemide on atrial natriuretic peptide , guanosine_cyclic_monophosphate , angiotensin_II , aldosterone , vasopressin , prostaglandin_E2 and blood volume in the nephrotic_syndrome .
16527843	0	aldosterone	74,85	angiotensin_II	100,114	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	production|amod|START_ENTITY regulation|nmod|production Involvement|nmod|regulation Involvement|nmod|END_ENTITY	Involvement of bone_morphogenetic_protein-6 in differential regulation of aldosterone production by angiotensin_II and potassium in human adrenocortical cells .
16627589	0	aldosterone	76,87	angiotensin_II	21,35	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	production|amod|START_ENTITY feedback|nmod|production regulated|nmod|feedback regulated|nmod|END_ENTITY	RGS2 is regulated by angiotensin_II and functions as a negative feedback of aldosterone production in H295R human adrenocortical cells .
1711598	0	aldosterone	26,37	angiotensin_II	72,86	aldosterone	angiotensin II	MESH:D000450	24179(Tax:10116)	Chemical	Gene	response|amod|START_ENTITY loading|nmod|response loading|nmod|infusion infusion|nmod|END_ENTITY	Effect of salt loading on aldosterone response to long-term infusion of angiotensin_II in rats .
176034	0	aldosterone	17,28	angiotensin_II	138,152	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	Effect|nmod|START_ENTITY induced|nsubj|Effect induced|nmod|infusion infusion|nmod|END_ENTITY	Effect on plasma aldosterone , renin activity and cortisol of acute volume depletion induced by ethacrynic_acid under constant infusion of angiotensin_II and dexamethasone in man .
1828176	0	aldosterone	79,90	angiotensin_II	19,33	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	biosynthesis|amod|START_ENTITY Sites|nmod|biosynthesis Sites|nmod|END_ENTITY	Sites of action of angiotensin_II , atrial_natriuretic_factor and guanabenz , on aldosterone biosynthesis .
1839152	0	aldosterone	74,85	angiotensin_II	56,70	aldosterone	angiotensin II	MESH:D000450	24179(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY END_ENTITY|nmod|secretion	Mechanisms involved in the interaction of dopamine with angiotensin_II on aldosterone secretion in isolated and cultured rat adrenal glomerulosa cells .
1846675	0	aldosterone	53,64	angiotensin_II	20,34	aldosterone	angiotensin II	MESH:D000450	24179(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY mechanism|nmod|secretion END_ENTITY|nmod|mechanism	Local generation of angiotensin_II as a mechanism of aldosterone secretion in rat adrenal capsules .
2019265	0	aldosterone	14,25	angiotensin_II	71,85	aldosterone	angiotensin II	MESH:D000450	24179(Tax:10116)	Chemical	Gene	Regulation|nmod|START_ENTITY synthase|nsubj|Regulation synthase|nmod|END_ENTITY	Regulation of aldosterone synthase cytochrome_P-450 in rat adrenals by angiotensin_II and potassium .
2145142	0	aldosterone	50,61	angiotensin_II	32,46	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	secretion|amod|START_ENTITY END_ENTITY|nmod|secretion	-LSB- Effects of alpha-human ANF and angiotensin_II on aldosterone secretion in vitro from cultured human adrenal tissues and APA tissues -RSB- .
2189608	0	aldosterone	42,53	angiotensin_II	68,82	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	production|amod|START_ENTITY stimulation|nmod|production involved|nmod|stimulation involved|nmod|END_ENTITY	Mechanisms involved in the stimulation of aldosterone production by angiotensin_II , vasopressin and endothelin .
2196065	0	aldosterone	61,72	angiotensin_II	84,98	aldosterone	angiotensin II	MESH:D000450	24179(Tax:10116)	Chemical	Gene	START_ENTITY|dep|induced induced|nmod|END_ENTITY	Effects of magnesium on changes in blood pressure and plasma aldosterone induced by angiotensin_II .
2333957	0	aldosterone	25,36	angiotensin_II	51,65	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Sustained stimulation of aldosterone production by angiotensin_II is potentiated by nickel .
233670	0	aldosterone	30,41	angiotensin_II	8,22	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	response|amod|START_ENTITY END_ENTITY|nmod|response	Role of angiotensin_II in the aldosterone secretory response to adrenocorticotropin in sodium-restricted normal human subjects .
2452924	0	aldosterone	30,41	angiotensin_II	73,87	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	response|amod|START_ENTITY response|nmod|END_ENTITY	Nifedipine does not blunt the aldosterone and cardiovascular response to angiotensin_II and potassium infusion in hypertensive patients .
2527200	0	aldosterone	27,38	angiotensin_II	56,70	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	sodium|nmod|START_ENTITY Effect|nmod|sodium secretion|nsubj|Effect secretion|nmod|stimulation stimulation|amod|END_ENTITY	Effect of plasma sodium on aldosterone secretion during angiotensin_II stimulation in normal humans .
2542384	0	aldosterone	45,56	angiotensin_II	69,83	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	Effects of H2-receptor antagonists on plasma aldosterone response to angiotensin_II in healthy subjects ; -LRB- II -RRB- .
27069636	0	aldosterone	110,121	angiotensin_II	41,55	aldosterone	angiotensin II	MESH:D000450	24179(Tax:10116)	Chemical	Gene	signaling|xcomp|START_ENTITY b-arrestin-dependent|acl|signaling terms|nmod|b-arrestin-dependent analogs|nmod|terms analogs|nsubj|study study|nmod|END_ENTITY	Structure-activity relationship study of angiotensin_II analogs in terms of b-arrestin-dependent signaling to aldosterone production .
2848091	0	aldosterone	64,75	angiotensin_II	177,191	aldosterone	angiotensin II	MESH:D000450	24179(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY stimulation|nmod|secretion restriction|nmod|stimulation Effects|nmod|restriction Effects|dep|report report|nmod|sensitivity sensitivity|nmod|amide amide|amod|END_ENTITY	Effects of dietary sodium restriction on peptide stimulation of aldosterone secretion by the isolated perfused rat adrenal gland in situ : a report of exceptional sensitivity to angiotensin_II amide .
2855590	0	aldosterone	53,64	angiotensin_II	10,24	aldosterone	angiotensin II	MESH:D000450	24179(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY Effect|nmod|production Effect|nmod|END_ENTITY	Effect of angiotensin_II and arginine_vasopressin on aldosterone production and phosphoinositide turnover in rat adrenal glomerulosa cells : a comparative study .
2938872	0	aldosterone	40,51	angiotensin_II	64,78	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	response|amod|START_ENTITY inhibits|dobj|response inhibits|nmod|END_ENTITY	Atrial natriuretic peptide inhibits the aldosterone response to angiotensin_II in man .
2948755	0	aldosterone	86,97	angiotensin_II	61,75	aldosterone	angiotensin II	MESH:D000450	24179(Tax:10116)	Chemical	Gene	inhibits|nmod|START_ENTITY inhibits|dobj|effect effect|nmod|END_ENTITY	Atrial_natriuretic_peptide inhibits the effect of endogenous angiotensin_II on plasma aldosterone in conscious sodium-depleted rats .
2987293	0	aldosterone	41,52	angiotensin_II	65,79	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	response|amod|START_ENTITY response|nmod|END_ENTITY	Effect of bromocriptine treatment on the aldosterone response to angiotensin_II and adrenocorticotropin in idiopathic_hyperaldosteronism .
2990765	0	aldosterone	65,76	angiotensin_II	97,111	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	unresponsiveness|amod|START_ENTITY unresponsiveness|nmod|END_ENTITY	A new family with dexamethasone-suppressible hyperaldosteronism : aldosterone unresponsiveness to angiotensin_II .
3000733	0	aldosterone	65,76	angiotensin_II	11,25	aldosterone	angiotensin II	MESH:D000450	24179(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	Effects of angiotensin_II , adrenocorticotropin , and potassium on aldosterone production in adrenal_zona_glomerulosa cells from streptozotocin-induced diabetic rats .
3009325	0	aldosterone	30,41	angiotensin_II	55,69	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	responses|amod|START_ENTITY inhibits|dobj|responses inhibits|nmod|END_ENTITY	Dopamine selectively inhibits aldosterone responses to angiotensin_II in humans .
3023030	0	aldosterone	104,115	angiotensin_II	53,67	aldosterone	angiotensin II	MESH:D000450	24179(Tax:10116)	Chemical	Gene	secretion|compound|START_ENTITY secretion|amod|END_ENTITY	Differential effects of atrial_natriuretic_factor on angiotensin_II - and adrenocorticotropin-stimulated aldosterone secretion .
3025245	0	aldosterone	11,22	angiotensin_II	36,50	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	responses|compound|START_ENTITY responses|nmod|END_ENTITY	Diminished aldosterone responses to angiotensin_II and adrenocorticotropin in hypocalcemic subjects : restoration of responsiveness with normocalcemia .
3351294	0	aldosterone	8,19	angiotensin_II	38,52	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	responsiveness|nsubj|START_ENTITY responsiveness|xcomp|END_ENTITY	Blunted aldosterone responsiveness to angiotensin_II in normotensive subjects with familial predisposition to essential hypertension .
3760114	0	aldosterone	70,81	angiotensin_II	107,121	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	START_ENTITY|nmod|infusion infusion|nmod|END_ENTITY	Effect of sodium balance and calcium channel-blocking drugs on plasma aldosterone responses to infusion of angiotensin_II in normal subjects and patients with essential hypertension .
3882312	0	aldosterone	17,28	angiotensin_II	70,84	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	response|amod|START_ENTITY reduces|dobj|response reduces|nmod|END_ENTITY	Dopamine reduces aldosterone and 18-hydroxycorticosterone response to angiotensin_II in patients with essential low-renin hypertension and idiopathic_hyperaldosteronism .
425848	0	aldosterone	64,75	angiotensin_II	27,41	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	START_ENTITY|nsubj|influence influence|nmod|END_ENTITY	The influence of sar1 ala8 angiotensin_II -LRB- saralasin -RRB- on plasma aldosterone in hypertensive patients .
4315980	0	aldosterone	52,63	angiotensin_II	14,28	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	tissue|amod|START_ENTITY biosynthesis|nmod|tissue END_ENTITY|nmod|biosynthesis	The effect of angiotensin_II on the biosynthesis of aldosterone by ox adrenocortical tissue in continuous-flow experiments in vitro .
447808	0	aldosterone	27,38	angiotensin_II	78,92	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	clearance|nmod|START_ENTITY decreases|nsubj|clearance decreases|nmod|infusion infusion|nmod|END_ENTITY	The metabolic clearance of aldosterone decreases similarly during infusion of angiotensin_II in patients with essential hypertension and in normal subjects .
455738	0	aldosterone	60,71	angiotensin_II	14,28	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	concentration|compound|START_ENTITY saralasin|nmod|concentration saralasin|nsubj|Effect Effect|nmod|antagonist antagonist|amod|END_ENTITY	Effect of the angiotensin_II antagonist saralasin on plasma aldosterone concentration and on blood pressure before and during sodium depletion in normal subjects .
583019	0	aldosterone	96,107	angiotensin_II	13,27	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|analogue analogue|amod|END_ENTITY	Effect of an angiotensin_II analogue upon blood pressure , plasma renin concentration and plasma aldosterone in hypertensive patients .
6092045	0	aldosterone	54,65	angiotensin_II	79,93	aldosterone	angiotensin II	MESH:D000450	24179(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY secretion|nmod|END_ENTITY	Atrial_natriuretic_factor inhibits the stimulation of aldosterone secretion by angiotensin_II , ACTH and potassium in vitro and angiotensin_II-induced steroidogenesis in vivo .
6100739	0	aldosterone	30,41	angiotensin_II	55,69	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	responses|amod|START_ENTITY inhibits|dobj|responses inhibits|nmod|END_ENTITY	Dopamine selectively inhibits aldosterone responses to angiotensin_II in man .
6125538	0	aldosterone	41,52	angiotensin_II	65,79	aldosterone	angiotensin II	MESH:D000450	24179(Tax:10116)	Chemical	Gene	response|amod|START_ENTITY response|nmod|END_ENTITY	Inhibitory effect of somatostatin on the aldosterone response to angiotensin_II : in vitro studies .
6148164	0	aldosterone	23,34	angiotensin_II	73,87	aldosterone	angiotensin II	MESH:D000450	24179(Tax:10116)	Chemical	Gene	responses|amod|START_ENTITY inhibition|nmod|responses END_ENTITY|nsubj|inhibition	Specific inhibition of aldosterone responses to endogenous and exogenous angiotensin_II by somatostatin .
6160772	0	aldosterone	60,71	angiotensin_II	36,50	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	secretion|amod|START_ENTITY inhibits|dobj|secretion inhibits|nsubj|infusion infusion|nmod|END_ENTITY	Intracerebroventricular infusion of angiotensin_II inhibits aldosterone secretion .
6252231	1	aldosterone	140,151	angiotensin_II	164,178	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	response|amod|START_ENTITY document|nmod|response document|nmod|END_ENTITY	To document a possible role of ACTH in the aldosterone response to angiotensin_II , we measured plasma aldosterone levels during physiological increments in plasma angiotensin_II in normal male volunteers on two occasions , once with suppression of endogenous ACTH secretion -LRB- dexamethasone or hydrocortisone -RRB- and again without ACTH suppression .
6252231	1	aldosterone	199,210	angiotensin_II	164,178	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	levels|compound|START_ENTITY measured|dobj|levels measured|advcl|document document|nmod|END_ENTITY	To document a possible role of ACTH in the aldosterone response to angiotensin_II , we measured plasma aldosterone levels during physiological increments in plasma angiotensin_II in normal male volunteers on two occasions , once with suppression of endogenous ACTH secretion -LRB- dexamethasone or hydrocortisone -RRB- and again without ACTH suppression .
6262059	0	aldosterone	55,66	angiotensin_II	25,39	aldosterone	angiotensin II	MESH:D000450	24179(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY antagonists|nmod|secretion antagonists|nsubj|Effects Effects|nmod|END_ENTITY	Effects of two different angiotensin_II antagonists on aldosterone secretion by isolated perfused rat zona glomerulosa cells .
6265141	0	aldosterone	33,44	angiotensin_II	58,72	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	responses|amod|START_ENTITY responses|nmod|END_ENTITY	Effect of propranolol therapy on aldosterone responses to angiotensin_II and adrenocorticotropic_hormone in essential hypertension .
6274907	0	aldosterone	33,44	angiotensin_II	73,87	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	secretion|amod|START_ENTITY inhibition|nmod|secretion independent|nsubj|inhibition independent|nmod|END_ENTITY	Acute dopaminergic inhibition of aldosterone secretion is independent of angiotensin_II and adrenocorticotropin .
6310234	2	aldosterone	113,124	angiotensin_II	49,63	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	START_ENTITY|nsubj|comparison comparison|nmod|effects effects|nmod|infusion infusion|amod|END_ENTITY	A comparison of the effects of angiotensin_II infusion and variations in salt intake on plasma aldosterone levels in normal subjects , patients with essential hypertension and patients with hyperaldosteronism .
6373591	0	aldosterone	36,47	angiotensin_II	61,75	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	responses|compound|START_ENTITY modulates|dobj|responses modulates|nmod|END_ENTITY	Dopamine modulates sodium-dependent aldosterone responses to angiotensin_II in humans .
6756162	0	aldosterone	15,26	angiotensin_II	73,87	aldosterone	angiotensin II	MESH:D000450	24179(Tax:10116)	Chemical	Gene	biosynthesis|amod|START_ENTITY Stimulation|nmod|biosynthesis Stimulation|dep|role role|nmod|END_ENTITY	Stimulation of aldosterone biosynthesis by sodium sequestration : role of angiotensin_II .
6822640	0	aldosterone	27,38	angiotensin_II	57,71	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	modulation|nmod|START_ENTITY responsiveness|nsubj|modulation responsiveness|xcomp|END_ENTITY	Dopaminergic modulation of aldosterone responsiveness to angiotensin_II with changes in sodium intake .
7002372	0	aldosterone	7,18	angiotensin_II	31,45	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	START_ENTITY|nmod|infusions infusions|compound|END_ENTITY	Plasma aldosterone response to angiotensin_II and potassium_chloride infusions in hypopituitary patients .
7032984	0	aldosterone	54,65	angiotensin_II	88,102	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	response|compound|START_ENTITY captopril|nmod|response captopril|nmod|END_ENTITY	-LSB- The effects of dexamethasone and captopril on plasma aldosterone response to exogenous angiotensin_II in normal men -LRB- author 's transl -RRB- -RSB- .
7049683	0	aldosterone	67,78	angiotensin_II	91,105	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	response|amod|START_ENTITY attenuation|nmod|response antagonist|nmod|attenuation Reversal|nmod|antagonist Reversal|nmod|infusion infusion|amod|END_ENTITY	Reversal by a dopamine antagonist of saline-induced attenuation of aldosterone response to angiotensin_II infusion in man .
7094540	0	aldosterone	11,22	angiotensin_II	41,55	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	Studies|nmod|START_ENTITY responsiveness|nsubj|Studies responsiveness|xcomp|END_ENTITY	Studies on aldosterone responsiveness to angiotensin_II during clinical variations in calcium metabolism in normal man .
7231191	0	aldosterone	41,52	angiotensin_II	23,37	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	Graded dose effects of angiotensin_II on aldosterone production in man during various levels of potassium intake .
7379348	0	aldosterone	84,95	angiotensin_II	54,68	aldosterone	angiotensin II	MESH:D000450	24179(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY stimulating|dobj|production END_ENTITY|advcl|stimulating	Different potencies of -LSB- Asp1 , Ile5 -RSB- - and -LSB- Asn1 , Val5 -RSB- - angiotensin_II in stimulating aldosterone production from rat adrenal zona glomerulosa cells in vitro .
7462385	0	aldosterone	11,22	angiotensin_II	35,49	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	START_ENTITY|nmod|infusion infusion|amod|END_ENTITY	The plasma aldosterone response to angiotensin_II infusion in aldosterone-producing adenoma and idiopathic_hyperaldosteronism .
7705006	0	aldosterone	87,98	angiotensin_II	124,138	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	responses|compound|START_ENTITY peptide|nmod|responses peptide|nmod|END_ENTITY	Comparative effects of atrial natriuretic peptide and brain natriuretic peptide on the aldosterone and pressor responses to angiotensin_II in man .
7733984	0	aldosterone	157,168	angiotensin_II	14,28	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	secretion|amod|START_ENTITY II|nmod|secretion kinase|dobj|II suggests|parataxis|kinase suggests|nsubj|Inhibition Inhibition|nmod|secretion secretion|amod|END_ENTITY	Inhibition of angiotensin_II - and potassium-mediated aldosterone secretion by KN-62 suggests involvement of Ca -LRB- 2 + -RRB- - calmodulin dependent protein kinase II in aldosterone secretion .
7733984	0	aldosterone	53,64	angiotensin_II	14,28	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	secretion|amod|START_ENTITY secretion|amod|END_ENTITY	Inhibition of angiotensin_II - and potassium-mediated aldosterone secretion by KN-62 suggests involvement of Ca -LRB- 2 + -RRB- - calmodulin dependent protein kinase II in aldosterone secretion .
8013547	0	aldosterone	102,113	angiotensin_II	13,27	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	production|nmod|START_ENTITY Effect|nmod|production Effect|nmod|antagonist antagonist|amod|END_ENTITY	Effect of an angiotensin_II receptor antagonist , CV-11974 , and its prodrug , TCV-116 , on production of aldosterone .
8405026	0	aldosterone	98,109	angiotensin_II	82,96	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	peptide|amod|START_ENTITY Effect|appos|peptide Effect|appos|function function|nmod|END_ENTITY	Effect of pinacidil on renal haemodynamics , tubular function and plasma levels of angiotensin_II , aldosterone and atrial natriuretic peptide in healthy man .
8700153	0	aldosterone	118,129	angiotensin_II	81,95	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	synthesis|amod|START_ENTITY synthesis|amod|END_ENTITY	Novel natriuretic peptide receptor/guanylyl cyclase A-selective agonist inhibits angiotensin_II - and forskolin-evoked aldosterone synthesis in a human zona glomerulosa cell line .
8952583	0	aldosterone	16,27	angiotensin_II	60,74	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	responses|compound|START_ENTITY blocks|dobj|responses blocks|nmod|END_ENTITY	Losartan blocks aldosterone and renal vascular responses to angiotensin_II in humans .
939003	0	aldosterone	12,23	angiotensin_II	46,60	aldosterone	angiotensin II	MESH:D000450	183	Chemical	Gene	Response|nmod|START_ENTITY pressure|nsubj|Response pressure|xcomp|END_ENTITY	Response of aldosterone and blood pressure to angiotensin_II infusion in anephric man .
9674639	0	aldosterone	90,101	angiotensin_II	27,41	aldosterone	angiotensin II	MESH:D000450	24179(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY regulation|dep|role regulation|nmod|subtypes subtypes|amod|END_ENTITY	Differential regulation of angiotensin_II receptor subtypes in the adrenal gland : role of aldosterone .
26709040	0	aldosterone	34,45	angiotensin_II_receptor_type_1	80,110	aldosterone	angiotensin II receptor type 1	MESH:D000450	81638(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY mediated|nsubjpass|effect mediated|nmod|END_ENTITY	The acute prothrombotic effect of aldosterone in rats is partially mediated via angiotensin_II_receptor_type_1 .
11086231	0	aldosterone	99,110	angiotensin_II_type_1-receptor	65,95	aldosterone	angiotensin II type 1-receptor	MESH:D000450	81638(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY END_ENTITY|nmod|synthesis	Differential effect of chronic inhibition of calcium channel and angiotensin_II_type_1-receptor on aldosterone synthesis in spontaneously hypertensive rats .
9430819	0	aldosterone	14,25	angiotensin_II_type_1_receptor	103,133	aldosterone	angiotensin II type 1 receptor	MESH:D000450	81638(Tax:10116)	Chemical	Gene	Expression|nmod|START_ENTITY synthase|nsubj|Expression synthase|nmod|END_ENTITY	Expression of aldosterone synthase cytochrome P450 -LRB- P450aldo -RRB- mRNA in rat adrenal glomerulosa cells by angiotensin_II_type_1_receptor .
2534410	0	aldosterone	52,63	angiotensin_converting_enzyme	71,100	aldosterone	angiotensin converting enzyme	MESH:D000450	1636	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|amod|END_ENTITY	Reciprocal changes in atrial natriuretic factor and aldosterone during angiotensin_converting_enzyme inhibition in man .
2998675	0	aldosterone	11,22	angiotensin_converting_enzyme	55,84	aldosterone	angiotensin converting enzyme	MESH:D000450	1636	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|amod|END_ENTITY	Inadequate aldosterone response to hyperkalemia during angiotensin_converting_enzyme inhibition in chronic_renal_failure .
7043022	0	aldosterone	59,70	angiotensin_converting_enzyme	10,39	aldosterone	angiotensin converting enzyme	MESH:D000450	1636	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|inhibitor inhibitor|amod|END_ENTITY	Effect of angiotensin_converting_enzyme inhibitor on serum aldosterone and potassium level .
8586522	0	aldosterone	82,93	angiotensin_converting_enzyme	18,47	aldosterone	angiotensin converting enzyme	MESH:D000450	1636	Chemical	Gene	START_ENTITY|nsubj|Response Response|nmod|END_ENTITY	Response of serum angiotensin_converting_enzyme , plasma renin activity and plasma aldosterone to conventional dialysis in patients on chronic haemodialysis .
1831735	0	aldosterone	111,122	atrial_natriuretic_factor	124,149	aldosterone	atrial natriuretic factor	MESH:D000450	4878	Chemical	Gene	angiotension|amod|START_ENTITY Relation|appos|angiotension END_ENTITY|nsubj|Relation	-LSB- Relation between traditional Chinese medicine differential types and plasma levels of renin , angiotension II , aldosterone , atrial_natriuretic_factor in patients with essential hypertension -RSB- .
2137294	0	aldosterone	9,20	atrial_natriuretic_factor	57,82	aldosterone	atrial natriuretic factor	MESH:D000450	100009087(Tax:9986)	Chemical	Gene	START_ENTITY|nmod|infusion infusion|nmod|END_ENTITY	Impaired aldosterone production by long-term infusion of atrial_natriuretic_factor .
2522415	0	aldosterone	14,25	atrial_natriuretic_factor	60,85	aldosterone	atrial natriuretic factor	MESH:D000450	24602(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY Regulation|nmod|receptor cytosol|nsubj|Regulation cytosol|nmod|END_ENTITY	Regulation of aldosterone receptor in rat kidney cytosol by atrial_natriuretic_factor .
2529999	1	aldosterone	131,142	atrial_natriuretic_factor	102,127	aldosterone	atrial natriuretic factor	MESH:D000450	24602(Tax:10116)	Chemical	Gene	regulation|compound|START_ENTITY Evidence|nmod|regulation Evidence|nmod|END_ENTITY	Evidence for role of atrial_natriuretic_factor in aldosterone and renal electrolyte regulation .
2545763	0	aldosterone	8,19	atrial_natriuretic_factor	34,59	aldosterone	atrial natriuretic factor	MESH:D000450	4878	Chemical	Gene	Lack|nmod|START_ENTITY inhibition|nsubj|Lack inhibition|nmod|END_ENTITY	Lack of aldosterone inhibition by atrial_natriuretic_factor in primary_aldosteronism : in vitro studies .
2853741	0	aldosterone	9,20	atrial_natriuretic_factor	67,92	aldosterone	atrial natriuretic factor	MESH:D000450	100009087(Tax:9986)	Chemical	Gene	START_ENTITY|nmod|infusion infusion|nmod|END_ENTITY	Impaired aldosterone production by chronic intravenous infusion of atrial_natriuretic_factor in rabbits .
2942044	0	aldosterone	49,60	atrial_natriuretic_factor	20,45	aldosterone	atrial natriuretic factor	MESH:D000450	24602(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY Effect|nmod|secretion Effect|nmod|END_ENTITY	Effect of synthetic atrial_natriuretic_factor on aldosterone secretion in the rat .
2942746	0	aldosterone	50,61	atrial_natriuretic_factor	10,35	aldosterone	atrial natriuretic factor	MESH:D000450	24602(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of atrial_natriuretic_factor on the plasma aldosterone response to potassium infusion in rats -- in vivo study .
2977168	0	aldosterone	170,181	atrial_natriuretic_factor	19,44	aldosterone	atrial natriuretic factor	MESH:D000450	4878	Chemical	Gene	activity|amod|START_ENTITY effect|nmod|activity Increase|dep|effect Increase|nmod|END_ENTITY	Increase in plasma atrial_natriuretic_factor and right atrial area during endogenous and exogenous volume loading in healthy volunteers : effect on plasma renin activity , aldosterone and antidiuretic_hormone .
2977175	0	aldosterone	24,35	atrial_natriuretic_factor	65,90	aldosterone	atrial natriuretic factor	MESH:D000450	4878	Chemical	Gene	secretion|amod|START_ENTITY control|nmod|secretion mediated|nsubjpass|control mediated|nmod|END_ENTITY	Dopaminergic control of aldosterone secretion is not mediated by atrial_natriuretic_factor in patients with essential hypertension .
3015692	0	aldosterone	14,25	atrial_natriuretic_factor	39,64	aldosterone	atrial natriuretic factor	MESH:D000450	4878	Chemical	Gene	synthesis|amod|START_ENTITY Inhibition|nmod|synthesis Inhibition|nmod|END_ENTITY	Inhibition of aldosterone synthesis by atrial_natriuretic_factor .
3023030	0	aldosterone	104,115	atrial_natriuretic_factor	24,49	aldosterone	atrial natriuretic factor	MESH:D000450	24602(Tax:10116)	Chemical	Gene	secretion|compound|START_ENTITY effects|nmod|secretion effects|nmod|END_ENTITY	Differential effects of atrial_natriuretic_factor on angiotensin_II - and adrenocorticotropin-stimulated aldosterone secretion .
6096716	0	aldosterone	14,25	atrial_natriuretic_factor	67,92	aldosterone	atrial natriuretic factor	MESH:D000450	24602(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY Inhibition|nmod|production Inhibition|nmod|glomerulosa glomerulosa|nmod|END_ENTITY	Inhibition of aldosterone production in the adrenal glomerulosa by atrial_natriuretic_factor .
6331441	0	aldosterone	62,73	atrial_natriuretic_factor	10,35	aldosterone	atrial natriuretic factor	MESH:D000450	24602(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY peptides|nmod|secretion Effect|dep|peptides Effect|nmod|END_ENTITY	Effect of atrial_natriuretic_factor -LRB- ANF -RRB- - related peptides on aldosterone secretion by adrenal glomerulosa cells : critical role of the intramolecular disulphide bond .
1828546	0	aldosterone	11,22	atrial_natriuretic_peptide	44,70	aldosterone	atrial natriuretic peptide	MESH:D000450	24602(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|amod|END_ENTITY	Effects of aldosterone and dexamethasone on atrial_natriuretic_peptide levels in preoptic and hypothalamic nuclei of adrenalectomized and intact rats .
2436485	0	aldosterone	60,71	atrial_natriuretic_peptide	30,56	aldosterone	atrial natriuretic peptide	MESH:D000450	24602(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY Role|nmod|production Role|nmod|effects effects|nmod|END_ENTITY	Role of calcium in effects of atrial_natriuretic_peptide on aldosterone production in adrenal glomerulosa cells .
2968143	0	aldosterone	123,134	atrial_natriuretic_peptide	62,88	aldosterone	atrial natriuretic peptide	MESH:D000450	24602(Tax:10116)	Chemical	Gene	involvement|nmod|START_ENTITY action|dep|involvement action|nmod|END_ENTITY	Natriuretic and diuretic action of centrally administered rat atrial_natriuretic_peptide -LRB- 99-126 -RRB- : possible involvement of aldosterone and the sympathoadrenal system .
3035853	0	aldosterone	64,75	atrial_natriuretic_peptide	11,37	aldosterone	atrial natriuretic peptide	MESH:D000450	100009087(Tax:9986)	Chemical	Gene	synthesis|amod|START_ENTITY END_ENTITY|nmod|synthesis	Effects of atrial_natriuretic_peptide , dopamine , and ouabain on aldosterone synthesis .
8735599	0	aldosterone	111,122	atrial_natriuretic_peptide	61,87	aldosterone	atrial natriuretic peptide	MESH:D000450	24602(Tax:10116)	Chemical	Gene	biosynthesis|amod|START_ENTITY inhibit|dobj|biosynthesis receptors|acl:relcl|inhibit receptors|amod|END_ENTITY	The H295R human adrenocortical cell line contains functional atrial_natriuretic_peptide receptors that inhibit aldosterone biosynthesis .
9673436	0	aldosterone	21,32	atrial_natriuretic_peptide	64,90	aldosterone	atrial natriuretic peptide	MESH:D000450	24602(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|acl|END_ENTITY	Inhibitory effect of aldosterone on the natriuretic response to atrial_natriuretic_peptide in hypocapnic rats .
9010484	0	aldosterone	74,85	atriopeptin	28,39	aldosterone	atriopeptin	MESH:D000450	4878	Chemical	Gene	START_ENTITY|nsubj|rhythms rhythms|nmod|END_ENTITY	Circadian rhythms of plasma atriopeptin , plasma renin activity and plasma aldosterone in patients with hepatorenal_syndrome .
3156141	0	aldosterone	41,52	beta-endorphin	16,30	aldosterone	beta-endorphin	MESH:D000450	5443	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of human beta-endorphin on plasma aldosterone concentrations in normal human subjects .
1312440	0	aldosterone	22,33	bradykinin	92,102	aldosterone	bradykinin	MESH:D000450	280833(Tax:9913)	Chemical	Gene	release|amod|START_ENTITY stimulates|dobj|release stimulates|nmod|cells cells|nmod|receptors receptors|amod|END_ENTITY	Bradykinin stimulates aldosterone release from cultured bovine adrenocortical cells through bradykinin B2 receptors .
9582501	0	aldosterone	139,150	bradykinin	90,100	aldosterone	bradykinin	MESH:D000450	280833(Tax:9913)	Chemical	Gene	production|amod|START_ENTITY increase|dobj|production increase|nsubj|END_ENTITY	Bovine adrenal glomerulosa cells express such a low level of functional B2 receptors that bradykinin does not significantly increase their aldosterone production .
21470289	0	aldosterone	14,25	brain_natriuretic_peptide	64,89	aldosterone	brain natriuretic peptide	MESH:D000450	4879	Chemical	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	Modulation of aldosterone release by epidural analgesia impacts brain_natriuretic_peptide : a link to stress_cardiomyopathy ?
21926338	0	aldosterone	63,74	cardiotrophin-1	11,26	aldosterone	cardiotrophin-1	MESH:D000450	13019(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|role role|nmod|END_ENTITY	A role for cardiotrophin-1 in myocardial_remodeling induced by aldosterone .
2762667	0	aldosterone	10,21	citrate_synthase	25,41	aldosterone	citrate synthase	MESH:D000450	100327271(Tax:9986)	Chemical	Gene	Action|nmod|START_ENTITY Action|nmod|END_ENTITY	Action of aldosterone on citrate_synthase in cultured renal collecting duct cells .
353285	0	aldosterone	33,44	citrate_synthase	13,29	aldosterone	citrate synthase	MESH:D000450	170587(Tax:10116)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of citrate_synthase by aldosterone in the rat kidney .
2836182	0	aldosterone	51,62	corticotropin-releasing_factor	11,41	aldosterone	corticotropin-releasing factor	MESH:D000450	1392	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of corticotropin-releasing_factor -LRB- CRF -RRB- on aldosterone and 18-hydroxycorticosterone in essential_hypertension and primary_aldosteronism .
6099779	0	aldosterone	51,62	corticotropin-releasing_factor	11,41	aldosterone	corticotropin-releasing factor	MESH:D000450	1392	Chemical	Gene	secretion|amod|START_ENTITY Effects|nmod|secretion Effects|nmod|END_ENTITY	Effects of corticotropin-releasing_factor -LRB- CRF -RRB- on aldosterone and 18-hydroxycorticosterone secretion .
6315759	0	aldosterone	42,53	corticotropin-releasing_factor	67,97	aldosterone	corticotropin-releasing factor	MESH:D000450	1392	Chemical	Gene	responses|amod|START_ENTITY responses|nmod|END_ENTITY	Plasma adrenocorticotropin , cortisol , and aldosterone responses to corticotropin-releasing_factor : modulatory effect of basal cortisol levels .
15044365	0	aldosterone	31,42	cyclooxygenase-2	46,62	aldosterone	cyclooxygenase-2	MESH:D000450	29527(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Direct and indirect effects of aldosterone on cyclooxygenase-2 and interleukin-6 expression in rat cardiac cells in culture and after myocardial_infarction .
7303036	0	aldosterone	70,81	cytochrome_P-450	12,28	aldosterone	cytochrome P-450	MESH:D000450	25251(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of cytochrome_P-450 in the synthesis of polar metabolites of aldosterone by microsomes of male rat liver .
15838303	0	aldosterone	27,38	endothelin-1	103,115	aldosterone	endothelin-1	MESH:D000450	1906	Chemical	Gene	production|amod|START_ENTITY stimulation|nmod|production stimulation|nmod|END_ENTITY	Synergistic stimulation of aldosterone production in human adrenocortical_carcinoma NCI-H295R cells by endothelin-1 and angiotensin_II .
17218419	0	aldosterone	19,30	endothelin-1	34,46	aldosterone	endothelin-1	MESH:D000450	24323(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|amod|END_ENTITY	A direct effect of aldosterone on endothelin-1 gene expression in vivo .
19073831	0	aldosterone	52,63	endothelin-1	8,20	aldosterone	endothelin-1	MESH:D000450	1906	Chemical	Gene	secretion|amod|START_ENTITY associated|nmod|secretion associated|nsubjpass|levels levels|amod|END_ENTITY	Adrenal endothelin-1 levels are not associated with aldosterone secretion in primary_aldosteronism .
7883855	0	aldosterone	100,111	endothelin-1	10,22	aldosterone	endothelin-1	MESH:D000450	1906	Chemical	Gene	concentrations|nmod|START_ENTITY impact|nmod|concentrations Effect|dep|impact Effect|nmod|END_ENTITY	Effect of endothelin-1 in man : impact on basal and adrenocorticotropin-stimulated concentrations of aldosterone .
8875700	0	aldosterone	77,88	endothelin-1	112,124	aldosterone	endothelin-1	MESH:D000450	24323(Tax:10116)	Chemical	Gene	effect|amod|START_ENTITY effect|nmod|END_ENTITY	Evidence that both ETA and ETB receptor subtypes are involved in the in vivo aldosterone secretagogue effect of endothelin-1 in rats .
945156	0	aldosterone	29,40	growth_hormone	91,105	aldosterone	growth hormone	MESH:D000450	2688	Chemical	Gene	rhythm|nmod|START_ENTITY END_ENTITY|nsubj|rhythm	The diurnal rhythm of plasma aldosterone , plasma renin activity , plasma cortisol and serum growth_hormone and subnormal responsiveness of aldosterone to angiotensin-II in the patients with normotensive acromegaly .
6337767	0	aldosterone	63,74	insulin	14,21	aldosterone	insulin	MESH:D000450	3630	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|END_ENTITY	The effect of insulin on the rise in blood pressure and plasma aldosterone after angiotensin_II in normal man .
10622410	0	aldosterone	14,25	insulin_receptor	29,45	aldosterone	insulin receptor	MESH:D000450	3643	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Inhibition by aldosterone of insulin_receptor mRNA levels and insulin binding in U-937 human promonocytic cells .
12767279	0	aldosterone	65,76	insulin_receptor	40,56	aldosterone	insulin receptor	MESH:D000450	3643	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|gene gene|compound|END_ENTITY	Transcriptional inhibition of the human insulin_receptor gene by aldosterone .
20335314	0	aldosterone	25,36	mPGES-1	0,7	aldosterone	mPGES-1	MESH:D000450	64292(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|impairs impairs|amod|END_ENTITY	mPGES-1 deletion impairs aldosterone escape and enhances sodium_appetite .
8459909	0	aldosterone	42,53	neurotensin	77,88	aldosterone	neurotensin	MESH:D000450	299757(Tax:10116)	Chemical	Gene	effect|amod|START_ENTITY effect|nmod|END_ENTITY	Arginine-vasopressin release mediates the aldosterone secretagogue effect of neurotensin in rats .
24895416	0	aldosterone	27,38	p38	47,50	aldosterone	p38	MESH:D000450	81649(Tax:10116)	Chemical	Gene	actions|nmod|START_ENTITY actions|nmod|END_ENTITY	Preconditioning actions of aldosterone through p38 signaling modulation in isolated rat hearts .
9002987	0	aldosterone	76,87	pituitary_adenylate_cyclase-activating_polypeptide	22,72	aldosterone	pituitary adenylate cyclase-activating polypeptide	MESH:D000450	615187(Tax:9913)	Chemical	Gene	secretion|amod|START_ENTITY END_ENTITY|nmod|secretion	Comparative effect of pituitary_adenylate_cyclase-activating_polypeptide on aldosterone secretion in normal bovine and human tumorous adrenal cells .
18036328	0	aldosterone	11,22	plasminogen_activator_inhibitor-1	44,77	aldosterone	plasminogen activator inhibitor-1	MESH:D000450	24617(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of aldosterone on the expression of plasminogen_activator_inhibitor-1 in renal mesangial cells : experiment with rat renal mesangial cells -RSB- .
16300990	0	aldosterone	95,106	procollagen_C-proteinase_enhancer-1	14,49	aldosterone	procollagen C-proteinase enhancer-1	MESH:D000450	29569(Tax:10116)	Chemical	Gene	stimulated|nmod|START_ENTITY stimulated|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of procollagen_C-proteinase_enhancer-1 in the remodeling rat heart is stimulated by aldosterone .
10022511	0	aldosterone	24,35	prolactin	11,20	aldosterone	prolactin	MESH:D000450	24683(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY Effects|nmod|secretion Effects|nmod|END_ENTITY	Effects of prolactin on aldosterone secretion in rat zona glomerulosa cells .
11828000	0	aldosterone	27,38	prostasin	14,23	aldosterone	prostasin	MESH:D000450	5652	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of prostasin by aldosterone in the kidney .
12626364	0	aldosterone	73,84	prostasin	26,35	aldosterone	prostasin	MESH:D000450	5652	Chemical	Gene	production|amod|START_ENTITY linked|nmod|production linked|nsubjpass|END_ENTITY	Adenovirus-mediated human prostasin gene delivery is linked to increased aldosterone production and hypertension in rats .
23344129	0	aldosterone	68,79	prostasin	8,17	aldosterone	prostasin	MESH:D000450	5652	Chemical	Gene	sodium|amod|START_ENTITY correlation|nmod|sodium END_ENTITY|dep|correlation	Urinary prostasin in normotensive individuals : correlation with the aldosterone to renin ratio and urinary sodium .
1071627	0	aldosterone	15,26	renal_kallikrein	49,65	aldosterone	renal kallikrein	MESH:D000450	24523(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of aldosterone and spironolactone on renal_kallikrein in the rat .
1005040	0	aldosterone	46,57	renin	26,31	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	systems|amod|START_ENTITY angiotensin|dep|systems changes|dep|angiotensin changes|nmod|END_ENTITY	Sequential changes in the renin -- angiotensin -- aldosterone systems and plasma progesterone concentration in normal and abnormal human pregnancy .
10594479	0	aldosterone	7,18	renin	22,27	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|nmod|ratio ratio|compound|END_ENTITY	Raised aldosterone to renin ratio predicts antihypertensive efficacy of spironolactone : a prospective cohort follow-up study .
1071585	0	aldosterone	11,22	renin	54,59	aldosterone	renin	MESH:D000450	24715(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of aldosterone and spironolactone on arterial renin in rats .
1077790	0	aldosterone	36,47	renin	16,21	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	system|amod|START_ENTITY angiotensin|dep|system role|dep|angiotensin role|nmod|END_ENTITY	The role of the renin -- angiotensin -- aldosterone system in cardiovascular homeostasis in normal man .
1130719	0	aldosterone	24,35	renin	4,9	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	system|amod|START_ENTITY angiotensin|dep|system END_ENTITY|dep|angiotensin	The renin -- angiotensin -- aldosterone system during cardiac surgery with morphine -- nitrous_oxide anesthesia .
1149405	0	aldosterone	68,79	renin	101,106	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|dobj|activity activity|compound|END_ENTITY	Effect of progesterone on renal sodium handling in man : relation to aldosterone excretion and plasma renin activity .
1152349	0	aldosterone	8,19	renin	31,36	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|dobj|activity activity|compound|END_ENTITY	-LSB- Plasma aldosterone and plasma renin activity in patients with essential and renal_hypertension under acute stimulation with saline depletion and acute suppression with saline infusion -RSB- .
11538925	0	aldosterone	68,79	renin	55,60	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	peptide|appos|START_ENTITY peptide|appos|END_ENTITY	Relationship between atrial natriuretic peptide -LRB- ANP -RRB- , renin -LRB- PRA -RRB- , aldosterone -LRB- PAC -RRB- , hemodynamic responses to lower body negative pressure -LRB- LBNP -RRB- and + Gz tolerance .
11549664	0	aldosterone	25,36	renin	174,179	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	Performance|nmod|START_ENTITY test|nsubj|Performance test|nmod|posture posture|acl|screening screening|nmod|adenoma adenoma|nmod|hypertensives hypertensives|compound|END_ENTITY	Performance of the basal aldosterone to renin ratio and of the renin stimulation test by furosemide and upright posture in screening for aldosterone-producing adenoma in low renin hypertensives .
11549664	0	aldosterone	25,36	renin	40,45	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|nmod|ratio ratio|compound|END_ENTITY	Performance of the basal aldosterone to renin ratio and of the renin stimulation test by furosemide and upright posture in screening for aldosterone-producing adenoma in low renin hypertensives .
1159066	0	aldosterone	39,50	renin	22,27	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|nsubj|Suppression Suppression|nmod|END_ENTITY	Suppression of plasma renin and plasma aldosterone during water immersion in normal man .
1190814	0	aldosterone	43,54	renin	37,42	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	system|amod|START_ENTITY due|nsubj|system END_ENTITY|xcomp|due	Hypertension , oedema , and suppressed renin aldosterone system due to unsupervised salt administration .
11928071	0	aldosterone	15,26	renin	37,42	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|nmod|concentration concentration|compound|END_ENTITY	Ratio of serum aldosterone to plasma renin concentration in essential hypertension and primary_aldosteronism .
12227124	0	aldosterone	14,25	renin	50,55	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|dobj|ratio ratio|compound|END_ENTITY	Use of plasma aldosterone concentration-to-plasma renin activity ratio as a screening test for primary_aldosteronism .
1239966	0	aldosterone	31,42	renin	8,13	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	-LSB- Plasma renin activity , plasma aldosterone and electrolyte balance in the postoperative period -LRB- author 's transl -RRB- -RSB- .
1245434	1	aldosterone	117,128	renin	74,79	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|nsubj|study study|nmod|activity activity|compound|END_ENTITY	A study of plasma renin activity , plasma cortisol and plasma aldosterone .
12643985	0	aldosterone	53,64	renin	31,36	aldosterone	renin	MESH:D000450	102190154	Chemical	Gene	START_ENTITY|nsubj|variations variations|nmod|activity activity|compound|END_ENTITY	Circadian variations of plasma renin activity -LRB- PRA -RRB- , aldosterone and electrolyte concentrations in plasma in pregnant and non-pregnant goats .
12925038	0	aldosterone	11,22	renin	45,50	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Low plasma aldosterone despite normal plasma renin activity in uncomplicated type 1 diabetes_mellitus : effects of RAAS stimulation .
1296875	0	aldosterone	107,118	renin	91,96	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|nsubj|peptide peptide|appos|activity activity|compound|END_ENTITY	-LSB- The circadian rhythm of plasma vasoactive intestinal peptide , atrial natriuretic peptide , renin activity , aldosterone and cortisol in heart transplantation .
1329566	0	aldosterone	25,36	renin	63,68	aldosterone	renin	MESH:D000450	24715(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY secretion|dep|involvement involvement|nmod|END_ENTITY	Interleukin-1 stimulates aldosterone secretion : involvement of renin , ACTH , and prostaglandins .
1352707	0	aldosterone	109,120	renin	89,94	aldosterone	renin	MESH:D000450	24715(Tax:10116)	Chemical	Gene	system|amod|START_ENTITY angiotensin|dep|system Evidence|dep|angiotensin Evidence|acl:relcl|endogenous endogenous|ccomp|exerts exerts|dobj|effect effect|nmod|END_ENTITY	Evidence that endogenous somatostatin -LRB- SRIF -RRB- exerts a tonic inhibitory effect on the rat renin -- angiotensin -- aldosterone system .
1354704	0	aldosterone	23,34	renin	7,12	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	electrolytes|amod|START_ENTITY activity|appos|electrolytes activity|compound|END_ENTITY	Plasma renin activity , aldosterone level , serum and urinary electrolytes in normal pregnant women aged 35 and older .
14660513	0	aldosterone	21,32	renin	44,49	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Diurnal variation of aldosterone and plasma renin activity : timing relation to melatonin and cortisol and consistency after prolonged bed rest .
15247156	0	aldosterone	69,80	renin	84,89	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|nmod|concentration concentration|compound|END_ENTITY	Rapid screening test for primary_hyperaldosteronism : ratio of plasma aldosterone to renin concentration determined by fully automated chemiluminescence immunoassays .
1531016	0	aldosterone	33,44	renin	8,13	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	concentration|compound|START_ENTITY END_ENTITY|dobj|concentration	-LSB- Plasma renin activity and serum aldosterone concentration in severe handicapped patients -RSB- .
15361760	0	aldosterone	64,75	renin	77,82	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Aldosterone_synthase gene -LRB- CYP11B2 -RRB- C-344T polymorphism , plasma aldosterone , renin activity and blood pressure in a multi-ethnic population .
15515576	0	aldosterone	51,62	renin	7,12	aldosterone	renin	MESH:D000450	101081695	Chemical	Gene	hormone|amod|START_ENTITY concentrations|nmod|hormone END_ENTITY|dobj|concentrations	Plasma renin activity and plasma concentrations of aldosterone , cortisol , adrenocorticotropic hormone , and alpha-melanocyte-stimulating hormone in healthy cats .
15681560	0	aldosterone	106,117	renin	142,147	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	concentration|compound|START_ENTITY concentration|nmod|activity activity|compound|END_ENTITY	Screening for primary_aldosteronism in essential hypertension : diagnostic accuracy of the ratio of plasma aldosterone concentration to plasma renin activity .
161182	0	aldosterone	80,91	renin	49,54	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|intake intake|nmod|variations variations|nmod|activity activity|compound|END_ENTITY	-LSB- Effects of water intake on variations of plasma renin activity -LRB- PRA -RRB- and blood aldosterone during physical exercise in man -RSB- .
16126559	0	aldosterone	7,18	renin	22,27	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|nmod|ratio ratio|compound|END_ENTITY	Plasma aldosterone to renin ratio predicts treatment response in primary_aldosteronism : is volume loading needed ?
16617310	0	aldosterone	38,49	renin	50,55	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	ratio|amod|START_ENTITY ratio|compound|END_ENTITY	Optimal use and interpretation of the aldosterone renin ratio to detect aldosterone excess in hypertension .
16617310	0	aldosterone	72,83	renin	50,55	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	excess|amod|START_ENTITY detect|dobj|excess Optimal|advcl|detect Optimal|dobj|use use|nmod|ratio ratio|compound|END_ENTITY	Optimal use and interpretation of the aldosterone renin ratio to detect aldosterone excess in hypertension .
168714	0	aldosterone	29,40	renin	79,84	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	variations|nmod|START_ENTITY variations|dep|relationship relationship|dep|activity activity|compound|END_ENTITY	Diurnal variations of plasma aldosterone in supine man : relationship to plasma renin activity and plasma cortisol .
172884	0	aldosterone	53,64	renin	27,32	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|nsubj|rhythm rhythm|nmod|activity activity|compound|END_ENTITY	Circadian rhythm of plasma renin activity and plasma aldosterone in normal man and in renal allograft recipients .
17490489	0	aldosterone	9,20	renin	21,26	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|ccomp|predict predict|nsubj|ratio ratio|compound|END_ENTITY	Does the aldosterone : renin ratio predict the efficacy of spironolactone over bendroflumethiazide in hypertension ?
176034	0	aldosterone	17,28	renin	30,35	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|appos|activity activity|compound|END_ENTITY	Effect on plasma aldosterone , renin activity and cortisol of acute volume depletion induced by ethacrynic_acid under constant infusion of angiotensin_II and dexamethasone in man .
17693975	0	aldosterone	46,57	renin	30,35	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	hormone|amod|START_ENTITY activity|appos|hormone activity|compound|END_ENTITY	A comparative study of plasma renin activity , aldosterone and atrial natriuretic hormone between normotensive and hypertensive people living at below sea level altitude -LRB- Jordan Valley -RRB- and those residing at moderate altitude above .
1822488	0	aldosterone	38,49	renin	21,26	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|nsubj|level level|nmod|END_ENTITY	-LSB- The level of plasma renin and plasma aldosterone activity in normotensive women and in pregnancy-induced arterial hypertension in a group of women from Cameroon -RSB- .
18306480	0	aldosterone	25,36	renin	40,45	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|nmod|ratio ratio|compound|END_ENTITY	The relationship between aldosterone to renin ratio and RI value of the uterine artery in the preeclamptic patient vs. normal pregnancy .
1872565	0	aldosterone	136,147	renin	159,164	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Primary hyperaldosteronism in England and Wales : a review of the use of a Supraregional Assay Service laboratory for the measurement of aldosterone and plasma renin activity .
18782187	0	aldosterone	97,108	renin	2,7	aldosterone	renin	MESH:D000450	24715(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY increases|dobj|production renin|acl:relcl|increases lacking|nmod|renin transcript|acl|lacking transcript|compound|END_ENTITY	A renin transcript lacking exon 1 encodes for a non-secretory intracellular renin that increases aldosterone production in transgenic rats .
18782187	0	aldosterone	97,108	renin	76,81	aldosterone	renin	MESH:D000450	24715(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY increases|dobj|production END_ENTITY|acl:relcl|increases	A renin transcript lacking exon 1 encodes for a non-secretory intracellular renin that increases aldosterone production in transgenic rats .
19351411	0	aldosterone	84,95	renin	106,111	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	active|amod|START_ENTITY ratio|amod|active ratio|compound|END_ENTITY	Graz Endocrine Causes of Hypertension -LRB- GECOH -RRB- study : a diagnostic accuracy study of aldosterone to active renin ratio in screening for primary_aldosteronism .
19427492	0	aldosterone	22,33	renin	4,9	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	system|compound|START_ENTITY system|amod|END_ENTITY	The renin angiotensin aldosterone system in hypertension : roles of insulin resistance and oxidative stress .
19786005	0	aldosterone	62,73	renin	93,98	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	concurrence|nmod|START_ENTITY concurrence|nmod|ratio ratio|compound|END_ENTITY	CYP11B2 gene haplotypes independently and in concurrence with aldosterone and aldosterone to renin ratio increase the risk of hypertension .
19933925	0	aldosterone	38,49	renin	51,56	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	reproducibility|nmod|START_ENTITY reproducibility|dep|ratio ratio|compound|END_ENTITY	Within-patient reproducibility of the aldosterone : renin ratio in primary_aldosteronism .
199474	0	aldosterone	42,53	renin	26,31	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	level|amod|START_ENTITY activity|appos|level activity|compound|END_ENTITY	-LSB- Effect of ACTH on plasma renin activity , aldosterone level and deoxycorticosterone level in humans -LRB- author 's transl -RRB- -RSB- .
20009770	0	aldosterone	24,35	renin	46,51	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Does the ratio of serum aldosterone to plasma renin activity predict the efficacy of diuretics in hypertension ?
20629332	0	aldosterone	27,38	renin	62,67	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|xcomp|renin renin|dobj|level level|compound|END_ENTITY	-LSB- The accuracy of combining aldosterone to renin ratio and low renin level in diagnosing primary_aldosteronism -RSB- .
20653151	0	aldosterone	36,47	renin	18,23	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	system|compound|START_ENTITY system|amod|END_ENTITY	Inhibition of the renin angiotensin aldosterone system : focus on aliskiren .
2076861	0	aldosterone	84,95	renin	30,35	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|nsubj|variations variations|nmod|END_ENTITY	Circadian variations of total renin , active renin , plasma renin activity and plasma aldosterone in clinically healthy young subjects .
2229301	0	aldosterone	15,26	renin	59,64	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	secretion|amod|START_ENTITY Alterations|nmod|secretion Alterations|nmod|hypertension hypertension|compound|END_ENTITY	Alterations in aldosterone secretion and metabolism in low renin hypertension .
22465166	0	aldosterone	90,101	renin	22,27	aldosterone	renin	MESH:D000450	24715(Tax:10116)	Chemical	Gene	improves|dobj|START_ENTITY improves|nsubj|Combination Combination|nmod|inhibition inhibition|compound|END_ENTITY	Combination of direct renin inhibition with angiotensin type 1 receptor blockade improves aldosterone but does not improve kidney_injury in the transgenic Ren2 rat .
22676457	0	aldosterone	7,18	renin	44,49	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|dobj|decrease decrease|compound|END_ENTITY	Plasma aldosterone concentration and plasma renin activity decrease during the third trimester in women with twin pregnancies .
23242734	0	aldosterone	22,33	renin	4,9	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|nsubj|angiotensin angiotensin|compound|END_ENTITY	The renin angiotensin aldosterone system and insulin resistance in humans .
23273069	0	aldosterone	49,60	renin	86,91	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|dobj|activity activity|compound|END_ENTITY	Association of antithrombin activity with plasma aldosterone concentration and plasma renin activity in pregnant women .
23344129	0	aldosterone	68,79	renin	83,88	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|nmod|ratio ratio|compound|END_ENTITY	Urinary prostasin in normotensive individuals : correlation with the aldosterone to renin ratio and urinary sodium .
23613013	0	aldosterone	36,47	renin	51,56	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	influence|dobj|START_ENTITY influence|xcomp|END_ENTITY	Assay characteristics influence the aldosterone to renin ratio as a screening tool for primary aldosteronism : results of the German Conn 's registry .
23864056	0	aldosterone	10,21	renin	81,86	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	breakthrough|amod|START_ENTITY Effect|nmod|breakthrough Effect|nmod|inhibitor inhibitor|compound|END_ENTITY	Effect of aldosterone breakthrough on albuminuria during treatment with a direct renin inhibitor and combined effect with a mineralocorticoid receptor antagonist .
24423297	0	aldosterone	7,18	renin	22,27	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|nmod|ratio ratio|compound|END_ENTITY	A high aldosterone to renin ratio is associated with high serum parathyroid_hormone concentrations in the general population .
24461920	0	aldosterone	41,52	renin	23,28	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	system|compound|START_ENTITY system|amod|END_ENTITY	Abnormal regulation of renin angiotensin aldosterone system is associated with right ventricular_dysfunction in hypertension .
24478712	0	aldosterone	84,95	renin	66,71	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	system|compound|START_ENTITY system|amod|END_ENTITY	Modulation of the cardiac sodium/bicarbonate cotransporter by the renin angiotensin aldosterone system : pathophysiological consequences .
24678899	0	aldosterone	36,47	renin	69,74	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|dobj|activity activity|compound|END_ENTITY	Negative association between plasma aldosterone concentration/plasma renin activity and morning blood pressure surge in never-treated hypertensive patients .
24945466	0	aldosterone	96,107	renin	78,83	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|volume volume|dep|role role|nmod|angiotensin angiotensin|compound|END_ENTITY	Regulation of cell volume and water transport -- an old fundamental role of the renin angiotensin aldosterone system components at the cellular level .
25143328	0	aldosterone	14,25	renin	35,40	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|dep|activity activity|compound|END_ENTITY	The ratios of aldosterone / plasma renin activity -LRB- ARR -RRB- versus aldosterone / direct renin concentration -LRB- ADRR -RRB- .
25143328	0	aldosterone	14,25	renin	84,89	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	concentration|amod|START_ENTITY concentration|amod|END_ENTITY	The ratios of aldosterone / plasma renin activity -LRB- ARR -RRB- versus aldosterone / direct renin concentration -LRB- ADRR -RRB- .
25143328	0	aldosterone	63,74	renin	35,40	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	The ratios of aldosterone / plasma renin activity -LRB- ARR -RRB- versus aldosterone / direct renin concentration -LRB- ADRR -RRB- .
25143328	0	aldosterone	63,74	renin	84,89	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	activity|nmod|START_ENTITY aldosterone|dep|activity concentration|amod|aldosterone concentration|amod|END_ENTITY	The ratios of aldosterone / plasma renin activity -LRB- ARR -RRB- versus aldosterone / direct renin concentration -LRB- ADRR -RRB- .
2542013	0	aldosterone	66,77	renin	88,93	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|nmod|hypertension hypertension|compound|END_ENTITY	Chronobiological evidence for an uncoupling of the Na,K-ATPase to aldosterone in normal renin hypertension .
25657757	0	aldosterone	53,64	renin	35,40	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|nsubj|review review|nmod|role role|nmod|angiotensin angiotensin|compound|END_ENTITY	A systematic review of the role of renin angiotensin aldosterone system genes in diabetes_mellitus , diabetic_retinopathy and diabetic_neuropathy .
26051856	0	aldosterone	30,41	renin	52,57	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|ratio ratio|compound|END_ENTITY	Effect of postural changes on aldosterone to plasma renin ratio in patients with suspected secondary hypertension .
26389772	0	aldosterone	51,62	renin	33,38	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|nsubj|update update|nmod|blockade blockade|nmod|angiotensin angiotensin|compound|END_ENTITY	An update of the blockade of the renin angiotensin aldosterone system in clinical practice .
26389772	0	aldosterone	51,62	renin	33,38	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|nsubj|update update|nmod|blockade blockade|nmod|angiotensin angiotensin|compound|END_ENTITY	An update of the blockade of the renin angiotensin aldosterone system in clinical practice .
2663759	0	aldosterone	76,87	renin	60,65	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|nsubj|kind kind|nmod|activity activity|compound|END_ENTITY	Does the kind of immunosuppressive therapy influence plasma renin activity , aldosterone and vasopressin in patients with a kidney transplant ?
2697984	0	aldosterone	45,56	renin	8,13	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	production|amod|START_ENTITY regulator|nmod|production END_ENTITY|dep|regulator	Adrenal renin : a possible local regulator of aldosterone production .
2846420	0	aldosterone	24,35	renin	48,53	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	response|nmod|START_ENTITY END_ENTITY|nsubj|response	Dissociated response of aldosterone from plasma renin activity during prolonged exercise under hypoxia .
2870870	0	aldosterone	45,56	renin	35,40	aldosterone	renin	MESH:D000450	24715(Tax:10116)	Chemical	Gene	pressure|aux|START_ENTITY pressure|aux|END_ENTITY	Effect of elevated blood pressure , renin and aldosterone on renal sodium handling in two-kidney Goldblatt hypertensive rats .
288834	0	aldosterone	20,31	renin	99,104	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	synthesis|amod|START_ENTITY defect|nmod|synthesis defect|nmod|END_ENTITY	Intrinsic defect of aldosterone synthesis in dexamethasone-responsive hypertension with suppressed renin and aldosterone .
2945679	0	aldosterone	78,89	renin	98,103	aldosterone	renin	MESH:D000450	24715(Tax:10116)	Chemical	Gene	atrial_natriuretic_factor|nmod|START_ENTITY infusion|nmod|atrial_natriuretic_factor Effect|nmod|infusion Effect|appos|activity activity|compound|END_ENTITY	Effect of chronic infusion of atrial_natriuretic_factor on plasma and urinary aldosterone , plasma renin activity , blood pressure and sodium excretion in 2-K , 1-C hypertensive rats .
2977168	0	aldosterone	170,181	renin	154,159	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Increase in plasma atrial_natriuretic_factor and right atrial area during endogenous and exogenous volume loading in healthy volunteers : effect on plasma renin activity , aldosterone and antidiuretic_hormone .
2982239	0	aldosterone	35,46	renin	74,79	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|nmod|spite spite|nmod|activity activity|compound|END_ENTITY	Prolonged ACTH infusion suppresses aldosterone secretion in spite of high renin activity .
2987296	0	aldosterone	46,57	renin	11,16	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	biosynthesis|amod|START_ENTITY Studies|nmod|biosynthesis Studies|nmod|activation activation|compound|END_ENTITY	Studies of renin activation and regulation of aldosterone and 18-hydroxycorticosterone biosynthesis in hyporeninemic_hypoaldosteronism .
2995484	0	aldosterone	98,109	renin	66,71	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|nsubj|activity activity|compound|END_ENTITY	Effects of converting enzyme inhibition on blood pressure , plasma renin activity -LRB- PRA -RRB- and plasma aldosterone in hypertensive diabetics compared to patients with essential hypertension .
3004180	0	aldosterone	33,44	renin	7,12	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	concentrations|compound|START_ENTITY END_ENTITY|dobj|concentrations	Plasma renin activity and plasma aldosterone concentrations in normotensive pregnant Nigerians .
3154627	0	aldosterone	54,65	renin	8,13	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	production|amod|START_ENTITY regulator|nmod|production END_ENTITY|dep|regulator	Adrenal renin : a possible local hormonal regulator of aldosterone production .
3279801	0	aldosterone	45,56	renin	28,33	aldosterone	renin	MESH:D000450	24715(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Dissociation Dissociation|nmod|END_ENTITY	Dissociation between plasma renin and plasma aldosterone induced by dietary glycine_hydrochloride .
3305759	0	aldosterone	81,92	renin	65,70	aldosterone	renin	MESH:D000450	24715(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Hormone profiles for progesterone , oestradiol , prolactin , plasma renin activity , aldosterone and corticosterone during pregnancy and pseudopregnancy in two strains of rat : correlation with renal studies .
3513487	0	aldosterone	62,73	renin	82,87	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	activity|dep|START_ENTITY activity|compound|END_ENTITY	Cardiovascular haemodynamics and the response of vasopressin , aldosterone , plasma renin activity and plasma catecholamines to head-up tilt in young and old healthy subjects .
3549504	0	aldosterone	47,58	renin	24,29	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	concentration|compound|START_ENTITY concentration|compound|END_ENTITY	Acute changes in plasma renin activity , plasma aldosterone concentration and plasma electrolyte concentrations following furosemide administration in patients with congestive_heart_failure -- interrelationships and diuretic response .
389942	0	aldosterone	46,57	renin	28,33	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	system|compound|START_ENTITY system|amod|END_ENTITY	Prostacyclin stimulates the renin angiotensin aldosterone system in man .
3905069	0	aldosterone	6,17	renin	29,34	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Serum aldosterone and plasma renin activity in normal and toxaemic pregnancies .
4006331	0	aldosterone	26,37	renin	8,13	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|angiotensin angiotensin|compound|END_ENTITY	Role of renin angiotensin aldosterone on minimal change_nephrotic_syndrome .
400714	0	aldosterone	119,130	renin	91,96	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	secretion|amod|START_ENTITY maintaining|dobj|secretion system|acl|maintaining system|compound|END_ENTITY	Studies of plasma aldosterone in anephric people : evidence for the fundamental role of the renin system in maintaining aldosterone secretion .
400714	0	aldosterone	18,29	renin	91,96	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	Studies|nmod|START_ENTITY Studies|dep|evidence evidence|nmod|role role|nmod|system system|compound|END_ENTITY	Studies of plasma aldosterone in anephric people : evidence for the fundamental role of the renin system in maintaining aldosterone secretion .
4317384	0	aldosterone	21,32	renin	137,142	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	secretion|amod|START_ENTITY secretion|dep|relation relation|nmod|activity activity|compound|END_ENTITY	Abnormally sustained aldosterone secretion during salt loading in patients with various forms of benign hypertension ; relation to plasma renin activity .
45268	0	aldosterone	44,55	renin	94,99	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	response|amod|START_ENTITY supporting|dobj|response supporting|nmod|suppression suppression|compound|END_ENTITY	The substitutive role of ACTH in supporting aldosterone response to head-up tilt during acute renin suppression in patients with essential hypertension .
513492	0	aldosterone	65,76	renin	39,44	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|activity activity|amod|potassium_chloride potassium_chloride|nmod|END_ENTITY	Effect of potassium_chloride on plasma renin activity and plasma aldosterone during sodium restriction in normal man .
518015	0	aldosterone	27,38	renin	60,65	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Circadian rhythms of serum aldosterone , cortisol and plasma renin activity in burn_injuries .
563323	0	aldosterone	29,40	renin	52,57	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	rhythm|nmod|START_ENTITY END_ENTITY|nsubj|rhythm	The diurnal rhythm of plasma aldosterone and plasma renin activity in patients with congestive_heart_failure .
583038	0	aldosterone	33,44	renin	7,12	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	concentration|compound|START_ENTITY END_ENTITY|dobj|concentration	Plasma renin activity and plasma aldosterone concentration in infants with various sodium intakes .
6099974	0	aldosterone	33,44	renin	7,12	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	concentrations|compound|START_ENTITY END_ENTITY|dobj|concentrations	Plasma renin activity and plasma aldosterone concentrations in untreated Nigerians with essential hypertension .
6203005	0	aldosterone	113,124	renin	59,64	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	kidney|nmod|START_ENTITY effects|nmod|kidney effects|nmod|release release|compound|END_ENTITY	Synergic effects of kallikrein-kinin and prostaglandins on renin release on infusion of isolated hog kidney with aldosterone .
6248590	0	aldosterone	40,51	renin	33,38	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|nsubj|characteristics characteristics|nmod|END_ENTITY	Rhythm characteristics of plasma renin , aldosterone and cortisol in five subtypes of mesor-hypertension .
6264356	0	aldosterone	13,24	renin	36,41	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	Behavior|nmod|START_ENTITY END_ENTITY|nsubj|Behavior	-LSB- Behavior of aldosterone and plasma renin activity after ACTH administration and insulin-induced hypoglycemia in patients with essential arterial hypertension -RSB- .
6320023	0	aldosterone	21,32	renin	41,46	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	-LSB- Variations in blood aldosterone , plasma renin activity and plasma levels of converting enzyme during bicarbonate dialysis in chronic_kidney_failure -RSB- .
6343273	0	aldosterone	79,90	renin	30,35	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	pressure|nmod|START_ENTITY inactive|nmod|pressure inactive|dobj|END_ENTITY	Effects of exogenous inactive renin on blood pressure and adrenal secretion of aldosterone and cortisol in the canine puppy .
6357558	0	aldosterone	39,50	renin	8,13	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	production|amod|START_ENTITY regulator|nmod|production END_ENTITY|dep|regulator	Adrenal renin : a possible regulator of aldosterone production .
6358049	0	aldosterone	23,34	renin	16,21	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|nsubj|Catecholamines Catecholamines|appos|END_ENTITY	Catecholamines , renin , aldosterone and arterial pressure in patients on chronic hemodialysis treatment .
6360878	0	aldosterone	20,31	renin	67,72	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	response|amod|START_ENTITY response|nmod|END_ENTITY	Studies of impaired aldosterone response to spironolactone-induced renin and potassium elevations in adenomatous but not hyperplastic primary_aldosteronism .
6367375	0	aldosterone	23,34	renin	16,21	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|nsubj|Prostaglandins Prostaglandins|appos|END_ENTITY	Prostaglandins , renin , aldosterone , and catecholamines in preeclampsia .
6369502	0	aldosterone	39,50	renin	7,12	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|nsubj|activity activity|compound|END_ENTITY	Plasma renin activity -LRB- PRA -RRB- and plasma aldosterone in the adrenal cortex hyperactivity .
6373096	0	aldosterone	71,82	renin	55,60	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	Effect|amod|START_ENTITY Effect|nmod|withdrawal withdrawal|nmod|pressure pressure|appos|activity activity|compound|END_ENTITY	Effect of alcohol withdrawal on blood pressure , plasma renin activity , aldosterone , cortisol and dopamine_beta-hydroxylase .
6384568	0	aldosterone	74,85	renin	48,53	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|activity activity|compound|END_ENTITY	Acute effect of atenolol on hemodynamic , plasma renin activity and plasma aldosterone concentration in the once daily oral administration .
6397760	0	aldosterone	112,123	renin	96,101	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	-LSB- Parametric methods applied to the standardization of gestational reference intervals for blood renin activity , aldosterone and cortisol using the transversal and longitudinal approach -RSB- .
6759133	0	aldosterone	33,44	renin	7,12	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	concentration|compound|START_ENTITY END_ENTITY|dobj|concentration	Plasma renin activity and plasma aldosterone concentration in infants with various potassium intakes .
6988802	0	aldosterone	25,36	renin	19,24	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	system|compound|START_ENTITY system|amod|END_ENTITY	-LSB- Variations of the renin aldosterone system in Cushing 's _ disease -LRB- author 's transl -RRB- -RSB- .
6989844	0	aldosterone	35,46	renin	58,63	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Normal integrated concentration of aldosterone and plasma renin activity : effect of age .
6997021	0	aldosterone	27,38	renin	82,87	aldosterone	renin	MESH:D000450	24715(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY modulation|nmod|secretion independent|nsubj|modulation independent|nmod|alterations alterations|nmod|secretion secretion|compound|END_ENTITY	Dopaminergic modulation of aldosterone secretion is independent of alterations in renin secretion .
6997819	0	aldosterone	23,34	renin	7,12	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	activity|compound|START_ENTITY END_ENTITY|dobj|activity	Plasma renin activity , aldosterone and dopamine_beta-hydroxylase activity as a function of age in normal children .
7007236	0	aldosterone	62,73	renin	84,89	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Abnormal urinary kallikrein in hypertension is not related to aldosterone or plasma renin activity .
7009025	0	aldosterone	23,34	renin	16,21	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	prostaglandin_E|compound|START_ENTITY Dissociation|dep|prostaglandin_E Dissociation|nmod|END_ENTITY	Dissociation of renin -- aldosterone and renal prostaglandin_E during volume expansion induced by immersion in normal man .
7037589	0	aldosterone	35,46	renin	28,33	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|nsubj|rhythms rhythms|nmod|END_ENTITY	Circadian rhythms of plasma renin , aldosterone and cortisol on habitual and low dietary sodium intake .
7043071	0	aldosterone	35,46	renin	17,22	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	system|compound|START_ENTITY system|dep|END_ENTITY	-LSB- Blood pressure , renin angiotensin aldosterone system and other cardiovascular risk factors in children of essential hypertensives -LRB- author 's transl -RRB- -RSB- .
7044409	0	aldosterone	25,36	renin	18,23	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	axis|amod|START_ENTITY Inhibition|dep|axis Inhibition|nmod|END_ENTITY	Inhibition of the renin -- aldosterone axis and of prolactin secretion during pregnancy by L-dopa .
7048230	0	aldosterone	56,67	renin	30,35	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|nsubj|rhythm rhythm|nmod|activity activity|compound|END_ENTITY	Nyctohemeral rhythm of plasma renin activity and plasma aldosterone in children .
7788884	0	aldosterone	14,25	renin	50,55	aldosterone	renin	MESH:D000450	24715(Tax:10116)	Chemical	Gene	biosynthesis|amod|START_ENTITY biosynthesis|nmod|END_ENTITY	Regulation of aldosterone biosynthesis by adrenal renin is mediated through AT1 receptors in renin transgenic rats .
7788884	0	aldosterone	14,25	renin	93,98	aldosterone	renin	MESH:D000450	24715(Tax:10116)	Chemical	Gene	biosynthesis|amod|START_ENTITY Regulation|nmod|biosynthesis mediated|nsubjpass|Regulation mediated|nmod|receptors receptors|nmod|rats rats|amod|END_ENTITY	Regulation of aldosterone biosynthesis by adrenal renin is mediated through AT1 receptors in renin transgenic rats .
8006920	0	aldosterone	86,97	renin	70,75	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	peptide|amod|START_ENTITY activity|appos|peptide activity|compound|END_ENTITY	Erythrocyte sodium-lithium countertransport : relationship with plasma renin activity , aldosterone and atrial natriuretic peptide in a population study .
837868	0	aldosterone	65,76	renin	44,49	aldosterone	renin	MESH:D000450	24715(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|loading loading|nmod|END_ENTITY	Effect of acute potassium loading on plasma renin and on urinary aldosterone in rats .
8677205	0	aldosterone	24,35	renin	8,13	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	activity|compound|START_ENTITY END_ENTITY|dobj|activity	-LSB- Plasma renin activity , aldosterone and adrenergic activity in patients with hypertension and in normotensives with a family history of hypertension -RSB- .
8819637	0	aldosterone	98,109	renin	82,87	aldosterone	renin	MESH:D000450	101081695	Chemical	Gene	ventilated|ccomp|START_ENTITY ventilated|nsubj|Effect Effect|nmod|stimulation stimulation|nmod|almitrine_bismesylate almitrine_bismesylate|nmod|activity activity|compound|END_ENTITY	Effect of arterial chemoreceptor stimulation with almitrine_bismesylate on plasma renin activity , aldosterone , ACTH and cortisol in anaesthetized , artificially ventilated cats .
895008	0	aldosterone	45,56	renin	38,43	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	Interrelations|amod|START_ENTITY Interrelations|nmod|END_ENTITY	Interrelations between age and plasma renin , aldosterone and cortisol , urinary catecholamines , and the body sodium/volume state in normal man .
907802	6	aldosterone	978,989	renin	960,965	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	decrease|nmod|START_ENTITY decrease|compound|END_ENTITY	The influence of the renin decrease on aldosterone is dependent on sodium balance and on the initial state of the renin angiotensin system .
9249232	0	aldosterone	21,32	renin	43,48	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|xcomp|plasma plasma|dobj|ratio ratio|compound|END_ENTITY	Evaluation of plasma aldosterone to plasma renin activity ratio in patients with primary_aldosteronism .
9351460	0	aldosterone	42,53	renin	15,20	aldosterone	renin	MESH:D000450	24715(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Role of tissue renin in the regulation of aldosterone biosynthesis in the adrenal cortex of nephrectomized rats .
947281	0	aldosterone	44,55	renin	18,23	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	START_ENTITY|nsubj|Changes Changes|nmod|activity activity|compound|END_ENTITY	Changes in plasma renin activity and plasma aldosterone in the induced paralytic attack of thyrotroxic periodic paralysis .
947943	0	aldosterone	81,92	renin	75,80	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	system|compound|START_ENTITY system|compound|END_ENTITY	Actions of growth hormone-release inhibiting hormone -LRB- somatostatin -RRB- on the renin aldosterone system .
9927293	3	aldosterone	818,829	renin	1009,1014	aldosterone	renin	MESH:D000450	24715(Tax:10116)	Chemical	Gene	levels|amod|START_ENTITY rise|nmod|levels inhibited|nsubjpass|rise inhibited|nmod|absence absence|acl|circulating circulating|dobj|END_ENTITY	Moreover , the rise of aldosterone levels was also inhibited by the AT1-receptor antagonist , losartan -LRB- 10 microg/kg x min , chronically i.p. from 8 + / - 2 to 199 + / - 26 ng/100 ml -RRB- , despite the absence of circulating renin and a reduction of ANG I to less than 10 % .
9928756	0	aldosterone	66,77	renin	33,38	aldosterone	renin	MESH:D000450	5972	Chemical	Gene	adenoma|amod|START_ENTITY patient|nmod|adenoma activity|nmod|patient activity|compound|END_ENTITY	High and non-suppressible plasma renin activity in a patient with aldosterone producing adenoma : pathophysiologic and diagnostic implications .
10751222	0	aldosterone	21,32	sgk	14,17	aldosterone	sgk	MESH:D000450	399130(Tax:8355)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of sgk by aldosterone and its effects on the epithelial Na -LRB- + -RRB- channel .
21169726	0	aldosterone	98,109	steroidogenic_factor-1	39,61	aldosterone	steroidogenic factor-1	MESH:D000450	2516	Chemical	Gene	secretion|compound|START_ENTITY effects|nmod|secretion effects|nmod|END_ENTITY	Differential effects of down-regulated steroidogenic_factor-1 on basal and angiotensin_II-induced aldosterone secretion .
16449345	0	aldosterone	53,64	vasopressin	23,34	aldosterone	vasopressin	MESH:D000450	551	Chemical	Gene	Evidence|nmod|START_ENTITY Evidence|nmod|END_ENTITY	Evidence for a role of vasopressin in the control of aldosterone secretion in primary_aldosteronism : in vitro and in vivo studies .
1652115	0	aldosterone	99,110	vasopressin	112,123	aldosterone	vasopressin	MESH:D000450	551	Chemical	Gene	prostaglandin_E2|dep|START_ENTITY prostaglandin_E2|dep|END_ENTITY	Effect of frusemide on atrial natriuretic peptide , guanosine_cyclic_monophosphate , angiotensin_II , aldosterone , vasopressin , prostaglandin_E2 and blood volume in the nephrotic_syndrome .
3513487	0	aldosterone	62,73	vasopressin	49,60	aldosterone	vasopressin	MESH:D000450	551	Chemical	Gene	activity|dep|START_ENTITY activity|compound|END_ENTITY	Cardiovascular haemodynamics and the response of vasopressin , aldosterone , plasma renin activity and plasma catecholamines to head-up tilt in young and old healthy subjects .
24736079	0	alectinib	135,144	ALK	82,85	alectinib	ALK	null	238	Chemical	Gene	confers|nmod|START_ENTITY confers|nsubj|mutation mutation|compound|END_ENTITY	Next-generation sequencing reveals a Novel NSCLC ALK F1174V mutation and confirms ALK G1202R mutation confers high-level resistance to alectinib -LRB- CH5424802/RO5424802 -RRB- in ALK-rearranged NSCLC patients who progressed on crizotinib .
24887559	0	alectinib	24,33	ALK	10,13	alectinib	ALK	null	238	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|END_ENTITY	Selective ALK inhibitor alectinib with potent antitumor activity in models of crizotinib resistance .
26464158	0	alectinib	87,96	ALK	0,3	alectinib	ALK	MESH:C582670	238	Chemical	Gene	confers|nmod|START_ENTITY confers|advcl|confers confers|nsubj|mutation mutation|compound|END_ENTITY	ALK F1174V mutation confers sensitivity while ALK I1171 mutation confers resistance to alectinib .
26464158	0	alectinib	87,96	ALK	46,49	alectinib	ALK	MESH:C582670	238	Chemical	Gene	confers|nmod|START_ENTITY confers|nsubj|mutation mutation|compound|END_ENTITY	ALK F1174V mutation confers sensitivity while ALK I1171 mutation confers resistance to alectinib .
26487585	0	alectinib	102,111	ALK	39,42	alectinib	ALK	MESH:C582670	238	Chemical	Gene	study|nmod|START_ENTITY results|nmod|study validation|dep|results validation|nmod|immunohistochemistry immunohistochemistry|compound|END_ENTITY	Prospective and clinical validation of ALK immunohistochemistry : results from the phase I/II study of alectinib for ALK-positive_lung_cancer -LRB- AF-001JP study -RRB- .
26811347	0	alectinib	129,138	ALK	18,21	alectinib	ALK	MESH:C582670	238	Chemical	Gene	resistance|nmod|START_ENTITY small-cell_lung_cancer|nmod|resistance Transformation|acl|small-cell_lung_cancer Transformation|nmod|adenocarcinoma adenocarcinoma|compound|END_ENTITY	Transformation of ALK rearrangement-positive adenocarcinoma to small-cell_lung_cancer in association with acquired resistance to alectinib .
26849637	0	alectinib	135,144	ALK	153,156	alectinib	ALK	MESH:C582670	11682(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mutated mutated|compound|END_ENTITY	Antitumor activity of alectinib , a selective ALK inhibitor , in an ALK-positive NSCLC cell line harboring G1269A mutation : Efficacy of alectinib against ALK G1269A mutated cells .
26849637	0	alectinib	135,144	ALK	45,48	alectinib	ALK	MESH:C582670	11682(Tax:10090)	Chemical	Gene	cells|amod|START_ENTITY Efficacy|nmod|cells activity|dep|Efficacy activity|nmod|alectinib alectinib|appos|inhibitor inhibitor|compound|END_ENTITY	Antitumor activity of alectinib , a selective ALK inhibitor , in an ALK-positive NSCLC cell line harboring G1269A mutation : Efficacy of alectinib against ALK G1269A mutated cells .
26849637	0	alectinib	22,31	ALK	153,156	alectinib	ALK	MESH:C582670	11682(Tax:10090)	Chemical	Gene	activity|nmod|START_ENTITY activity|dep|Efficacy Efficacy|nmod|cells cells|amod|alectinib alectinib|nmod|mutated mutated|compound|END_ENTITY	Antitumor activity of alectinib , a selective ALK inhibitor , in an ALK-positive NSCLC cell line harboring G1269A mutation : Efficacy of alectinib against ALK G1269A mutated cells .
26849637	0	alectinib	22,31	ALK	45,48	alectinib	ALK	MESH:C582670	11682(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Antitumor activity of alectinib , a selective ALK inhibitor , in an ALK-positive NSCLC cell line harboring G1269A mutation : Efficacy of alectinib against ALK G1269A mutated cells .
18486585	0	alendronate	119,130	ERK	135,138	alendronate	ERK	MESH:D019386	24338(Tax:10116)	Chemical	Gene	Stimulation|nmod|START_ENTITY Stimulation|nmod|END_ENTITY	Stimulation of osteogenic differentiation and inhibition of adipogenic differentiation in bone marrow stromal cells by alendronate via ERK and JNK activation .
11443170	0	alendronate	33,44	GH	64,66	alendronate	GH	MESH:D019386	2688	Chemical	Gene	START_ENTITY|nmod|growth_hormone growth_hormone|appos|END_ENTITY	Additional beneficial effects of alendronate in growth_hormone -LRB- GH -RRB- - deficient adults with osteoporosis receiving long-term recombinant human GH replacement therapy : a randomized controlled trial .
12052462	0	alendronate	52,63	IGF-1	40,45	alendronate	IGF-1	MESH:D019386	16000(Tax:10090)	Chemical	Gene	mice|amod|START_ENTITY mice|appos|END_ENTITY	Effect of insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- plus alendronate on bone density during puberty in IGF-1-deficient MIDI mice .
23888411	0	alendronate	125,136	Osteoprotegerin	0,15	alendronate	Osteoprotegerin	MESH:D019386	4982	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|dep|effect	Osteoprotegerin , RANKL , and bone_turnover in primary_hyperparathyroidism : the effect of parathyroidectomy and treatment with alendronate .
22278430	0	alendronate	21,32	fibroblast_growth_factor_23	36,63	alendronate	fibroblast growth factor 23	MESH:D019386	8074	Chemical	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	Potential effects of alendronate on fibroblast_growth_factor_23 levels and effective control of hypercalciuria in an adult with Jansen 's _ metaphyseal_chondrodysplasia .
12052462	0	alendronate	52,63	insulin-like_growth_factor-1	10,38	alendronate	insulin-like growth factor-1	MESH:D019386	16000(Tax:10090)	Chemical	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Effect of insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- plus alendronate on bone density during puberty in IGF-1-deficient MIDI mice .
19574937	0	alendronate	11,22	osteoprotegerin	52,67	alendronate	osteoprotegerin	MESH:D019386	4982	Chemical	Gene	treatment|amod|START_ENTITY Effects|nmod|treatment Effects|nmod|activator activator|compound|END_ENTITY	Effects of alendronate treatment on serum levels of osteoprotegerin and total receptor activator of nuclear factor kappaB in women with postmenopausal_osteoporosis .
23268391	0	alendronate	11,22	osteoprotegerin	41,56	alendronate	osteoprotegerin	MESH:D019386	18383(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expressions expressions|nmod|activator activator|compound|END_ENTITY	-LSB- Effect of alendronate on expressions of osteoprotegerin and receptor activator of nuclear factor kB ligand in mouse osteoblasts -RSB- .
9278398	0	alendronate	9,20	protein-tyrosine_phosphatases	29,58	alendronate	protein-tyrosine phosphatases	MESH:D019386	5805	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|END_ENTITY	How does alendronate inhibit protein-tyrosine_phosphatases ?
22140123	0	alfacalcidol	94,106	fibroblast_growth_factor_23	11,38	alfacalcidol	fibroblast growth factor 23	MESH:C008088	8074	Chemical	Gene	Changes|nmod|START_ENTITY Changes|nmod|END_ENTITY	Changes in fibroblast_growth_factor_23 during treatment of secondary_hyperparathyroidism with alfacalcidol or paricalcitol .
9285148	0	alfacalcidol	12,24	insulin	34,41	alfacalcidol	insulin	MESH:C008088	3630	Chemical	Gene	improves|nsubj|START_ENTITY improves|dobj|resistance resistance|compound|END_ENTITY	Intravenous alfacalcidol improves insulin resistance in hemodialysis patients .
9708607	0	alfacalcidol	42,54	parathyroid_hormone	73,92	alfacalcidol	parathyroid hormone	MESH:C008088	5741	Chemical	Gene	START_ENTITY|nmod|suppression suppression|nmod|END_ENTITY	Controlled trial of falecalcitriol versus alfacalcidol in suppression of parathyroid_hormone in hemodialysis patients with secondary_hyperparathyroidism .
15601808	0	alfentanil	87,97	cytochrome_P4503A	25,42	alfentanil	cytochrome P4503A	MESH:D015760	1576	Chemical	Gene	START_ENTITY|nsubj|Evaluation Evaluation|nmod|END_ENTITY	Evaluation of first-pass cytochrome_P4503A -LRB- CYP3A -RRB- and P-glycoprotein activities using alfentanil and fexofenadine in combination .
19555185	0	aliphatic_carboxylic_acids	16,42	tyrosinase	94,104	aliphatic carboxylic acids	tyrosinase	null	7299	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nsubj|effects	Dual effects of aliphatic_carboxylic_acids on cresolase and catecholase reactions of mushroom tyrosinase .
22772063	0	alisertib	27,36	Aurora_A_kinase	58,73	alisertib	Aurora A kinase	MESH:C550258	6790	Chemical	Gene	study|appos|START_ENTITY study|appos|inhibitor inhibitor|compound|END_ENTITY	Phase II study of MLN8237 -LRB- alisertib -RRB- , an investigational Aurora_A_kinase inhibitor , in patients with platinum-resistant or - refractory epithelial ovarian , _ fallopian_tube , or primary_peritoneal_carcinoma .
24043741	0	alisertib	18,27	Aurora_A_kinase	41,56	alisertib	Aurora A kinase	MESH:C550258	6790	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Phase II study of alisertib , a selective Aurora_A_kinase inhibitor , in relapsed and refractory aggressive B - and T-cell non-Hodgkin_lymphomas .
25609923	0	alisertib	41,50	Aurora_kinase_A	22,37	alisertib	Aurora kinase A	MESH:C550258	6790	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of mitotic Aurora_kinase_A by alisertib induces apoptosis and autophagy of human gastric_cancer AGS and NCI-N78 cells .
26999067	0	alisertib	58,67	Aurora_kinase_A	81,96	alisertib	Aurora kinase A	MESH:C550258	6790	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	An update on the pharmacokinetics and pharmacodynamics of alisertib , a selective Aurora_kinase_A inhibitor .
16300168	0	aliskiren	57,66	renin	41,46	aliskiren	renin	MESH:C446481	5972	Chemical	Gene	START_ENTITY|nsubj|interactions interactions|nmod|inhibitor inhibitor|compound|END_ENTITY	Pharmacokinetic interactions of the oral renin inhibitor aliskiren with lovastatin , atenolol , celecoxib and cimetidine .
18786303	0	aliskiren	74,83	renin	58,63	aliskiren	renin	MESH:C446481	5972	Chemical	Gene	START_ENTITY|nsubj|study study|nmod|interactions interactions|nmod|inhibitor inhibitor|compound|END_ENTITY	A study of the pharmacokinetic interactions of the direct renin inhibitor aliskiren with metformin , pioglitazone and fenofibrate in healthy subjects .
18957387	0	aliskiren	38,47	renin	22,27	aliskiren	renin	MESH:C446481	5972	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|inhibitor inhibitor|compound|END_ENTITY	Effects of the direct renin inhibitor aliskiren and atenolol alone or in combination in patients with hypertension .
19296761	0	aliskiren	29,38	renin	49,54	aliskiren	renin	MESH:C446481	5972	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Cardio-renal protection with aliskiren , a direct renin inhibitor , in the ASPIRE HIGHER program .
22677784	0	aliskiren	37,46	renin	21,26	aliskiren	renin	MESH:C446481	24715(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|inhibitor inhibitor|compound|END_ENTITY	Effect of the direct renin inhibitor aliskiren in the prevention of experimental contrast-induced_nephropathy in the rat .
23420778	0	aliskiren	53,62	renin	37,42	aliskiren	renin	MESH:C446481	24715(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|inhibitor inhibitor|compound|END_ENTITY	Renoprotective effects of the direct renin inhibitor aliskiren on gentamicin-induced nephrotoxicity in rats .
23438195	0	aliskiren	27,36	renin	103,108	aliskiren	renin	MESH:C446481	5972	Chemical	Gene	improves|nsubj|START_ENTITY improves|dobj|vascular vascular|acl|remodelling remodelling|advcl|harbouring harbouring|dobj|END_ENTITY	The direct renin inhibitor aliskiren improves vascular remodelling in transgenic rats harbouring human renin and angiotensinogen genes .
23676368	0	aliskiren	45,54	renin	28,33	aliskiren	renin	MESH:C446481	5972	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Effectiveness of the direct renin inhibitor , aliskiren , in patients with resistant hypertension .
24140549	0	aliskiren	67,76	renin	50,55	aliskiren	renin	MESH:C446481	24715(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	The synergistic effect of mizoribine and a direct renin inhibitor , aliskiren , on unilateral ureteral_obstruction induced renal_fibrosis in rats .
11428010	0	alkaloid_G	36,46	Cope	65,69	alkaloid G	Cope	MESH:C431588	11316	Chemical	Gene	START_ENTITY|nmod|rearrangement rearrangement|compound|END_ENTITY	Stereocontrolled total synthesis of alkaloid_G via the oxy-anion Cope rearrangement and improved total synthesis of -LRB- + -RRB- - ajmaline .
16808005	0	alkamides	85,94	CYP2D6	74,80	alkamides	CYP2D6	null	1565	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|appos|END_ENTITY	Mechanism-based inhibition of human liver microsomal cytochrome_P450_2D6 -LRB- CYP2D6 -RRB- by alkamides of Piper nigrum .
16808005	0	alkamides	85,94	cytochrome_P450_2D6	53,72	alkamides	cytochrome P450 2D6	null	1565	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Mechanism-based inhibition of human liver microsomal cytochrome_P450_2D6 -LRB- CYP2D6 -RRB- by alkamides of Piper nigrum .
19773105	0	alkane	14,20	alkB	36,40	alkane	alkB	CHEBI:18310	8846	Chemical	Gene	monooxygenase|amod|START_ENTITY genes|amod|monooxygenase genes|appos|END_ENTITY	Expression of alkane monooxygenase -LRB- alkB -RRB- genes by plant-associated bacteria in the rhizosphere and endosphere of Italian ryegrass -LRB- Lolium multiflorum L. -RRB- grown in diesel contaminated soil .
19820158	0	alkane	6,12	alkB	31,35	alkane	alkB	CHEBI:18310	8846	Chemical	Gene	hydroxylase|amod|START_ENTITY diversity|amod|hydroxylase diversity|appos|END_ENTITY	Novel alkane hydroxylase gene -LRB- alkB -RRB- diversity in sediments associated with hydrocarbon seeps in the Timor Sea , Australia .
19882279	0	alkane	63,69	alkB	102,106	alkane	alkB	CHEBI:18310	8846	Chemical	Gene	quantification|nmod|START_ENTITY methods|nmod|quantification monooxygenase|nsubj|methods monooxygenase|dobj|genes genes|appos|END_ENTITY	MPN - and real-time-based PCR methods for the quantification of alkane monooxygenase homologous genes -LRB- alkB -RRB- in environmental samples .
22578458	0	alkanes	106,113	5-lipoxygenase	117,131	alkanes	5-lipoxygenase	MESH:D000473	240	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Evaluation of endo - and exo-aryl-substitutions and central scaffold modifications on diphenyl substituted alkanes as 5-lipoxygenase activating protein inhibitors .
11133096	0	alkanesulfonyl_fluorides	36,60	lipoprotein_lipase	14,32	alkanesulfonyl fluorides	lipoprotein lipase	null	4023	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of lipoprotein_lipase by alkanesulfonyl_fluorides .
19072093	3	alkoxymethyl	652,664	C-5	648,651	alkoxymethyl	C-5	null	727	Chemical	Gene	group|compound|START_ENTITY group|compound|END_ENTITY	This method confirmed the pseudoaxial preference of C-3 alkoxy-substituted systems and revealed the conformational preference of the C-5 alkoxymethyl group .
9350042	0	alkoxyresorufin	95,110	cytochrome_P450	48,63	alkoxyresorufin	cytochrome P450	null	4051	Chemical	Gene	activities|nmod|START_ENTITY activities|amod|END_ENTITY	A microassay for the detection of low levels of cytochrome_P450 O-deethylation activities with alkoxyresorufin substrates .
8250964	0	alkoxyresorufins	44,60	Cytochrome_P450	0,15	alkoxyresorufins	Cytochrome P450	null	25251(Tax:10116)	Chemical	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Cytochrome_P450 induction and metabolism of alkoxyresorufins , ethylmorphine and testosterone in cultured hepatocytes from goats , sheep and cattle .
2231606	0	alkyl	56,61	thymidylate_synthase	23,43	alkyl	thymidylate synthase	null	22171(Tax:10090)	Chemical	Gene	inhibitors|dep|START_ENTITY inhibitors|compound|END_ENTITY	Quinazoline antifolate thymidylate_synthase inhibitors : alkyl , substituted alkyl , and aryl substituents in the C2 position .
26924701	0	alkyl-phenanthrene	35,53	CYP1A	15,20	alkyl-phenanthrene	CYP1A	null	100125806(Tax:8090)	Chemical	Gene	metabolism|amod|START_ENTITY inhibition|nmod|metabolism inhibition|nsubj|effects effects|nmod|END_ENTITY	The effects of CYP1A inhibition on alkyl-phenanthrene metabolism and embryotoxicity in marine medaka -LRB- Oryzias melastigma -RRB- .
2577378	0	alkyl_D-cysteinates	34,53	aminopeptidase_M	14,30	alkyl D-cysteinates	aminopeptidase M	null	290	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of aminopeptidase_M by alkyl_D-cysteinates .
19959358	0	alkyl_amine	36,47	renin	48,53	alkyl amine	renin	CHEBI:13759	5972	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Optimization of orally bioavailable alkyl_amine renin inhibitors .
23518072	0	alkyl_glycerophosphate	10,32	peroxisome_proliferator-activated_receptor_gamma	54,102	alkyl glycerophosphate	peroxisome proliferator-activated receptor gamma	null	19016(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Effect of alkyl_glycerophosphate on the activation of peroxisome_proliferator-activated_receptor_gamma and glucose uptake in C2C12 cells .
11193391	0	alkyl_p-hydroxybenzoates	29,53	estrogen_receptor_alpha	63,86	alkyl p-hydroxybenzoates	estrogen receptor alpha	null	2099	Chemical	Gene	binding|nmod|START_ENTITY binding|nmod|END_ENTITY	-LSB- Competitive binding of some alkyl_p-hydroxybenzoates to human estrogen_receptor_alpha and beta -RSB- .
24767084	0	alkyl_protocatechuates	36,58	Lipoxygenase	0,12	alkyl protocatechuates	Lipoxygenase	null	547836(Tax:3847)	Chemical	Gene	activity|nmod|START_ENTITY END_ENTITY|dobj|activity	Lipoxygenase inhibitory activity of alkyl_protocatechuates .
6784755	0	alkyl_sulfate	21,34	trypsin_inhibitor	93,110	alkyl sulfate	trypsin inhibitor	CHEBI:29281	548021(Tax:3847)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of long-chain alkyl_sulfate binding on circular dichroism and conformation of soybean trypsin_inhibitor .
15556647	0	alkylamides	10,21	TNF-alpha	31,40	alkylamides	TNF-alpha	null	7124	Chemical	Gene	modulate|nsubj|START_ENTITY modulate|dobj|expression expression|amod|END_ENTITY	Echinacea alkylamides modulate TNF-alpha gene expression via cannabinoid receptor CB2 and multiple signal transduction pathways .
7019208	0	alkylamines	40,51	D-serine_dehydratase	16,36	alkylamines	D-serine dehydratase	CHEBI:22331	63826	Chemical	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of D-serine_dehydratase by alkylamines via a transimination of enzyme-linked cofactor .
15142554	0	alkylamino_acids	55,71	DHFR	75,79	alkylamino acids	DHFR	null	1719	Chemical	Gene	conjugates|nmod|START_ENTITY conjugates|nmod|inhibitors inhibitors|amod|END_ENTITY	Lipophilic conjugates of methotrexate with short-chain alkylamino_acids as DHFR inhibitors .
1324685	0	alkylbenzoylacrylic_acids	31,56	Phospholipase_A2	0,16	alkylbenzoylacrylic acids	Phospholipase A2	null	151056	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|END_ENTITY	Phospholipase_A2 inhibition by alkylbenzoylacrylic_acids .
3607034	0	alkylphenols	82,94	dopamine_beta-hydroxylase	32,57	alkylphenols	dopamine beta-hydroxylase	null	1621	Chemical	Gene	inactivation|nmod|START_ENTITY inactivation|nmod|END_ENTITY	Mechanism-based inactivation of dopamine_beta-hydroxylase by p-cresol and related alkylphenols .
10583226	0	alkylphosphocholines	49,69	BCR-ABL	0,7	alkylphosphocholines	BCR-ABL	null	25	Chemical	Gene	efficacy|nmod|START_ENTITY influences|dobj|efficacy influences|nsubj|END_ENTITY	BCR-ABL influences the antileukaemic efficacy of alkylphosphocholines .
8937424	0	alkylsulphinyl-diphenylimidazole	55,87	ACAT	88,92	alkylsulphinyl-diphenylimidazole	ACAT	null	6646	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	Hypolipidaemic properties of a potent and bioavailable alkylsulphinyl-diphenylimidazole ACAT inhibitor -LRB- RP_73163 -RRB- in animals fed diets low in cholesterol .
16285759	0	alkyltrimethylammonium_bromides	20,51	C10	53,56	alkyltrimethylammonium bromides	C10	null	113246	Chemical	Gene	START_ENTITY|dep|- -|compound|END_ENTITY	Self-aggregation of alkyltrimethylammonium_bromides -LRB- C10 - , C12 - , C14 - , and C16TAB -RRB- and their binary mixtures in aqueous medium : a critical and comprehensive assessment of interfacial behavior and bulk properties with reference to two types of micelle formation .
10211829	0	alkylurea	45,54	ribonuclease_A	27,41	alkylurea	ribonuclease A	null	6035	Chemical	Gene	solutions|compound|START_ENTITY END_ENTITY|nmod|solutions	Thermodynamic stability of ribonuclease_A in alkylurea solutions and preferential solvation changes accompanying its thermal denaturation : a calorimetric and spectroscopic study .
17007800	0	alkylureas	45,55	myoglobin	16,25	alkylureas	myoglobin	null	4151	Chemical	Gene	START_ENTITY|nsubj|Interactions Interactions|nmod|END_ENTITY	Interactions of myoglobin with urea and some alkylureas .
20541934	0	alkynyl	15,22	Bcr-Abl	43,50	alkynyl	Bcr-Abl	null	25	Chemical	Gene	START_ENTITY|dobj|inhibitors inhibitors|nmod|END_ENTITY	Broad spectrum alkynyl inhibitors of T315I Bcr-Abl .
11459663	0	alkynyl	16,23	C-8	34,37	alkynyl	C-8	null	3224	Chemical	Gene	chains|amod|START_ENTITY chains|nmod|END_ENTITY	Introduction of alkynyl chains on C-8 of adenosine led to very selective antagonists of the A -LRB- 3 -RRB- adenosine receptor .
26076884	0	alkynyl_carbonates	43,61	CO2	67,70	alkynyl carbonates	CO2	null	717	Chemical	Gene	synthesis|nmod|START_ENTITY synthesis|nmod|END_ENTITY	A facile one-step synthesis of star-shaped alkynyl_carbonates from CO2 .
21916510	0	alkynylphenoxyacetic_acid	56,81	CRTH2	82,87	alkynylphenoxyacetic acid	CRTH2	null	11251	Chemical	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Discovery of potent , selective , and orally bioavailable alkynylphenoxyacetic_acid CRTH2 -LRB- DP2 -RRB- receptor antagonists for the treatment of allergic inflammatory diseases .
21916510	0	alkynylphenoxyacetic_acid	56,81	DP2	89,92	alkynylphenoxyacetic acid	DP2	null	11251	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Discovery of potent , selective , and orally bioavailable alkynylphenoxyacetic_acid CRTH2 -LRB- DP2 -RRB- receptor antagonists for the treatment of allergic inflammatory diseases .
20404325	0	all-trans-retinal	113,130	ATP-binding_cassette_transporter	67,99	all-trans-retinal	ATP-binding cassette transporter	CHEBI:17898	24	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of extracellular domain 2 of the human retina-specific ATP-binding_cassette_transporter -LRB- ABCA4 -RRB- with all-trans-retinal .
4518143	0	all-trans-retinal	46,63	rhodopsin	31,40	all-trans-retinal	rhodopsin	CHEBI:17898	24717(Tax:10116)	Chemical	Gene	Studies|nmod|START_ENTITY Studies|nmod|END_ENTITY	Studies on the regeneration of rhodopsin from all-trans-retinal in isolated rat retinae .
7660322	0	all-trans-retinoic_acid	53,76	CD-1	80,84	all-trans-retinoic acid	CD-1	MESH:D014212	111334(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|compound|END_ENTITY	Maternal restraint stress-enhanced teratogenicity of all-trans-retinoic_acid in CD-1 mice .
11302942	0	all-trans-retinoic_acid	83,106	CYP26	43,48	all-trans-retinoic acid	CYP26	MESH:D014212	1592	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of receptor-selective retinoids on CYP26 gene expression and metabolism of all-trans-retinoic_acid in intestinal cells .
12054474	0	all-trans-retinoic_acid	88,111	CYP26	35,40	all-trans-retinoic acid	CYP26	MESH:D014212	154985(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Cloning Cloning|nmod|cytochrome_P450RAI cytochrome_P450RAI|appos|END_ENTITY	Cloning of rat cytochrome_P450RAI -LRB- CYP26 -RRB- cDNA and regulation of its gene expression by all-trans-retinoic_acid in vivo .
8792611	0	all-trans-retinoic_acid	11,34	HoxD	58,62	all-trans-retinoic acid	HoxD	MESH:D014212	111337(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of all-trans-retinoic_acid on skeletal pattern , 5 ` HoxD gene expression , and RAR beta 2/beta 4 promoter activity in embryonic mouse limbs .
16804330	0	all-trans-retinoic_acid	122,145	IL-1beta	14,22	all-trans-retinoic acid	IL-1beta	MESH:D014212	3553	Chemical	Gene	effects|nmod|START_ENTITY Expression|dep|effects Expression|nmod|END_ENTITY	Expression of IL-1beta , IL-1 receptor type I and IL-1_receptor_antagonist in human aortic smooth muscle cells : effects of all-trans-retinoic_acid .
12054474	0	all-trans-retinoic_acid	88,111	cytochrome_P450RAI	15,33	all-trans-retinoic acid	cytochrome P450RAI	MESH:D014212	154985(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Cloning Cloning|nmod|END_ENTITY	Cloning of rat cytochrome_P450RAI -LRB- CYP26 -RRB- cDNA and regulation of its gene expression by all-trans-retinoic_acid in vivo .
7837814	0	all-trans-retinoic_acid	49,72	interleukin-8	110,123	all-trans-retinoic acid	interleukin-8	MESH:D014212	3576	Chemical	Gene	matured|nmod|START_ENTITY cells|acl|matured properties|nmod|cells properties|dep|differences differences|nmod|response response|nmod|END_ENTITY	Functional properties of HL60 cells matured with all-trans-retinoic_acid and DMSO : differences in response to interleukin-8 and fMLP .
8900181	0	all-trans-retinoic_acid	62,85	interleukin-8	26,39	all-trans-retinoic acid	interleukin-8	MESH:D014212	3576	Chemical	Gene	transcription|nmod|START_ENTITY transcription|amod|END_ENTITY	Synergistic activation of interleukin-8 gene transcription by all-trans-retinoic_acid and tumor_necrosis_factor-alpha involves the transcription factor NF-kappaB .
1545142	0	all-trans-retinoic_acid	100,123	ornithine_decarboxylase	14,37	all-trans-retinoic acid	ornithine decarboxylase	MESH:D014212	4953	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of ornithine_decarboxylase gene expression , polyamine levels , and DNA synthetic rates by all-trans-retinoic_acid in cultured human keratinocytes .
9820587	0	all-trans-retinoic_acid	112,135	ornithine_decarboxylase	76,99	all-trans-retinoic acid	ornithine decarboxylase	MESH:D014212	4953	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Modulation of UVA-induced lipid peroxidation and suppression of UVB-induced ornithine_decarboxylase response by all-trans-retinoic_acid in human skin fibroblasts in vitro .
9808423	0	all-trans-retinoic_acid	114,137	transcription_factor_IIB	36,60	all-trans-retinoic acid	transcription factor IIB	MESH:D014212	29105	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of human transcription_factor_IIB in SMMC-7721 human hepatocellular_carcinoma cells by all-trans-retinoic_acid and phorbol_12-myristate_13-acetate .
3002442	0	all-trans-retinoids	0,19	rhodopsin	91,100	all-trans-retinoids	rhodopsin	null	509933(Tax:9913)	Chemical	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	all-trans-retinoids and dihydroretinoids as probes of the role of chromophore structure in rhodopsin activation .
14661078	0	all-trans-retinol	116,133	RDH8	149,153	all-trans-retinol	RDH8	MESH:D014801	50700	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Using denaturing HPLC for SNP discovery and genotyping , and establishing the linkage disequilibrium pattern for the all-trans-retinol dehydrogenase -LRB- RDH8 -RRB- gene .
17081426	0	all-trans-retinol	57,74	RDH8	90,94	all-trans-retinol	RDH8	MESH:D014801	50700	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Establishing the linkage disequilibrium pattern for the all-trans-retinol dehydrogenase -LRB- RDH8 -RRB- gene -RSB- .
21043051	0	all-trans-retinol	41,58	RDH8	74,78	all-trans-retinol	RDH8	MESH:D014801	50700	Chemical	Gene	dehydrogenase|amod|START_ENTITY association|nmod|dehydrogenase Investigation|nmod|association Investigation|appos|END_ENTITY	Investigation of the association between all-trans-retinol dehydrogenase -LRB- RDH8 -RRB- polymorphisms and high_myopia in Chinese .
25560245	0	all-trans-retinol	87,104	organic_anion_transporting_polypeptide_1A2	6,48	all-trans-retinol	organic anion transporting polypeptide 1A2	MESH:D014801	6579	Chemical	Gene	uptake|nmod|START_ENTITY mediates|dobj|uptake mediates|nsubj|END_ENTITY	Human organic_anion_transporting_polypeptide_1A2 -LRB- OATP1A2 -RRB- mediates cellular uptake of all-trans-retinol in human retinal pigmented epithelial cells .
16262246	0	all-trans-retinyl_ester	26,49	RPE65	53,58	all-trans-retinyl ester	RPE65	CHEBI:63410	6121	Chemical	Gene	Specificity|nmod|START_ENTITY Specificity|nmod|END_ENTITY	Specificity of binding of all-trans-retinyl_ester to RPE65 .
11872149	0	all-trans_retinoic_acid	81,104	ALDH1A1	108,115	all-trans retinoic acid	ALDH1A1	MESH:D014212	216	Chemical	Gene	cells|amod|START_ENTITY cells|nmod|END_ENTITY	4 - -LRB- N,N-dipropylamino -RRB- benzaldehyde inhibits the oxidation of all-trans retinal to all-trans_retinoic_acid by ALDH1A1 , but not the differentiation of HL-60 promyelocytic_leukemia cells exposed to all-trans retinal .
15664402	0	all-trans_retinoic_acid	11,34	APJ	54,57	all-trans retinoic acid	APJ	MESH:D014212	83518(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of all-trans_retinoic_acid on orphan receptor APJ signaling in spontaneously hypertensive rats .
20513361	0	all-trans_retinoic_acid	59,82	CYP26A1	27,34	all-trans retinoic acid	CYP26A1	MESH:D014212	1592	Chemical	Gene	importance|nmod|START_ENTITY importance|nmod|END_ENTITY	The relative importance of CYP26A1 in hepatic clearance of all-trans_retinoic_acid .
22982089	0	all-trans_retinoic_acid	94,117	Cellular_retinoic_acid_binding_protein_I	0,40	all-trans retinoic acid	Cellular retinoic acid binding protein I	MESH:D014212	1381	Chemical	Gene	mediates|advcl|START_ENTITY mediates|nsubj|END_ENTITY	Cellular_retinoic_acid_binding_protein_I mediates rapid non-canonical activation of ERK1/2 by all-trans_retinoic_acid .
25486480	0	all-trans_retinoic_acid	94,117	EVI1	13,17	all-trans retinoic acid	EVI1	MESH:D014212	2122	Chemical	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	The oncogene EVI1 enhances transcriptional and biological responses of human myeloid cells to all-trans_retinoic_acid .
19204112	0	all-trans_retinoic_acid	22,45	Foxp3	80,85	all-trans retinoic acid	Foxp3	MESH:D014212	20371(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|induction induction|nmod|END_ENTITY	Contrasting roles for all-trans_retinoic_acid in TGF-beta-mediated induction of Foxp3 and Il10 genes in developing regulatory T cells .
9357979	0	all-trans_retinoic_acid	21,44	HOXB	69,73	all-trans retinoic acid	HOXB	MESH:D014212	3210	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Distinct patterns of all-trans_retinoic_acid dependent expression of HOXB and HOXC homeogenes in human embryonal_and_small-cell_lung_carcinoma cell lines .
17451530	0	all-trans_retinoic_acid	120,143	HSP110	0,6	all-trans retinoic acid	HSP110	MESH:D014212	15505(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|advmod|END_ENTITY	HSP110 , caspase-3_and _ -9 expression in physiological apoptosis and apoptosis induced by in vivo embryonic exposition to all-trans_retinoic_acid or irradiation during early mouse eye development .
16143075	0	all-trans_retinoic_acid	33,56	IFN-alpha	71,80	all-trans retinoic acid	IFN-alpha	MESH:D014212	3439	Chemical	Gene	START_ENTITY|acl|combined combined|nmod|END_ENTITY	-LSB- Study on the synergic effect of all-trans_retinoic_acid combined with IFN-alpha on the proliferation and differentiation of HL-60 cells -RSB- .
24694005	0	all-trans_retinoic_acid	28,51	MMP-2	56,61	all-trans retinoic acid	MMP-2	MESH:D014212	4313	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Potential signal pathway of all-trans_retinoic_acid for MMP-2 and MMP-9 expression in injury podocyte induced by adriamycin .
10651729	0	all-trans_retinoic_acid	26,49	P-glycoprotein	8,22	all-trans retinoic acid	P-glycoprotein	MESH:D014212	5243	Chemical	Gene	resistance|amod|START_ENTITY END_ENTITY|nmod|resistance	Role of P-glycoprotein in all-trans_retinoic_acid -LRB- ATRA -RRB- resistance in acute_promyelocytic_leukaemia cells : analysis of intracellular concentration of ATRA .
25030439	0	all-trans_retinoic_acid	34,57	P-glycoprotein	91,105	all-trans retinoic acid	P-glycoprotein	MESH:D014212	67078(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effect of 9-cis retinoic_acid and all-trans_retinoic_acid in combination with verapamil on P-glycoprotein expression in L1210 cells .
10428509	0	all-trans_retinoic_acid	39,62	P39	102,105	all-trans retinoic acid	P39	MESH:D014212	8941	Chemical	Gene	induced|nmod|START_ENTITY induced|nmod|END_ENTITY	Two pathways of apoptosis induced with all-trans_retinoic_acid and etoposide in the myeloid cell line P39 .
25849135	0	all-trans_retinoic_acid	31,54	Pin1	7,11	all-trans retinoic acid	Pin1	MESH:D014212	5300	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Active Pin1 is a key target of all-trans_retinoic_acid in acute_promyelocytic_leukemia and breast_cancer .
9028332	0	all-trans_retinoic_acid	34,57	Stat1	0,5	all-trans retinoic acid	Stat1	MESH:D014212	6772	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Stat1 is induced and activated by all-trans_retinoic_acid in acute_promyelocytic_leukemia cells .
18798497	0	all-trans_retinoic_acid	12,35	TGF-beta_1	57,67	all-trans retinoic acid	TGF-beta 1	MESH:D014212	59086(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of all-trans_retinoic_acid on the expression of TGF-beta_1 and COL-I in rat model of peritoneal dialysis -RSB- .
14582708	0	all-trans_retinoic_acid	26,49	THP-1	79,84	all-trans retinoic acid	THP-1	MESH:D014212	2736	Chemical	Gene	cells|amod|START_ENTITY cells|appos|END_ENTITY	Down-regulation of ID2 by all-trans_retinoic_acid in monocytic_leukemia cells -LRB- THP-1 -RRB- .
10866818	0	all-trans_retinoic_acid	102,125	TIMP-1	75,81	all-trans retinoic acid	TIMP-1	MESH:D014212	7076	Chemical	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Mechanisms of induction of human tissue_inhibitor_of_metalloproteinases-1 -LRB- TIMP-1 -RRB- gene expression by all-trans_retinoic_acid in combination with basic_fibroblast_growth_factor .
15728448	0	all-trans_retinoic_acid	14,37	TLR2	53,57	all-trans retinoic acid	TLR2	MESH:D014212	7097	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Cutting edge : all-trans_retinoic_acid down-regulates TLR2 expression and function .
24816818	0	all-trans_retinoic_acid	30,53	Tal2	0,4	all-trans retinoic acid	Tal2	MESH:D014212	21350(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|expression expression|amod|END_ENTITY	Tal2 expression is induced by all-trans_retinoic_acid in P19 cells prior to acquisition of neural fate .
22327096	0	all-trans_retinoic_acid	73,96	Thrombomodulin	0,14	all-trans retinoic acid	Thrombomodulin	MESH:D014212	7056	Chemical	Gene	effects|nmod|START_ENTITY enhances|dobj|effects enhances|nsubj|END_ENTITY	Thrombomodulin enhances the antifibrinolytic and antileukemic effects of all-trans_retinoic_acid in acute_promyelocytic_leukemia cells .
7878635	0	all-trans_retinoic_acid	28,51	Thrombomodulin	0,14	all-trans retinoic acid	Thrombomodulin	MESH:D014212	7056	Chemical	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	Thrombomodulin induction by all-trans_retinoic_acid is independent of HL-60 cells differentiation to neutrophilic cells .
25896049	0	all-trans_retinoic_acid	23,46	apelin	64,70	all-trans retinoic acid	apelin	MESH:D014212	8862	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	-LSB- Role and mechanism of all-trans_retinoic_acid in up-regulating apelin expression in vascular smooth muscle cells -RSB- .
24500985	0	all-trans_retinoic_acid	11,34	cyclooxygenase-2	56,72	all-trans retinoic acid	cyclooxygenase-2	MESH:D014212	29527(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of all-trans_retinoic_acid on signal pathway of cyclooxygenase-2 and Smad3 in transforming_growth_factor-b-stimulated glomerular mesangial cells .
16619265	0	all-trans_retinoic_acid	42,65	dHAND	14,19	all-trans retinoic acid	dHAND	MESH:D014212	34379(Tax:7227)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of dHAND protein expression by all-trans_retinoic_acid through ET-1 / ETAR signaling in H9c2 cells .
19843176	0	all-trans_retinoic_acid	82,105	ecotropic_viral_integration_site_1	33,67	all-trans retinoic acid	ecotropic viral integration site 1	MESH:D014212	2122	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Zinc finger transcription factor ecotropic_viral_integration_site_1 is induced by all-trans_retinoic_acid -LRB- ATRA -RRB- and acts as a dual modulator of the ATRA response .
11861271	0	all-trans_retinoic_acid	72,95	erythropoietin	40,54	all-trans retinoic acid	erythropoietin	MESH:D014212	2056	Chemical	Gene	START_ENTITY|nsubj|response response|nmod|END_ENTITY	Sustained response to recombinant human erythropoietin and intermittent all-trans_retinoic_acid in patients with myelodysplastic_syndromes .
16740727	0	all-trans_retinoic_acid	49,72	folate_receptor_beta	25,45	all-trans retinoic acid	folate receptor beta	MESH:D014212	2350	Chemical	Gene	inhibitors|amod|START_ENTITY END_ENTITY|nmod|inhibitors	Synergistic induction of folate_receptor_beta by all-trans_retinoic_acid and histone_deacetylase inhibitors in acute_myelogenous_leukemia cells : mechanism and utility in enhancing selective growth inhibition by antifolates .
9625433	0	all-trans_retinoic_acid	59,82	interferon-alpha2a	20,38	all-trans retinoic acid	interferon-alpha2a	MESH:D014212	3440	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Cytotoxic effect of interferon-alpha2a in combination with all-trans_retinoic_acid or cisplatin in human ovarian_carcinoma cell lines .
12216088	0	all-trans_retinoic_acid	62,85	interferon_alpha2b	17,35	all-trans retinoic acid	interferon alpha2b	MESH:D014212	3440	Chemical	Gene	START_ENTITY|nsubj|trial trial|nmod|END_ENTITY	Phase I trial of interferon_alpha2b and liposome-encapsulated all-trans_retinoic_acid in the treatment of patients with advanced_renal_cell_carcinoma .
19461187	0	all-trans_retinoic_acid	146,169	interleukin-6	92,105	all-trans retinoic acid	interleukin-6	MESH:D014212	3569	Chemical	Gene	treatment|nmod|START_ENTITY END_ENTITY|nmod|treatment	A case of acute_promyelocytic_leukemia showing transient thrombocytosis caused by increased interleukin-6 and thrombopoietin after treatment with all-trans_retinoic_acid and chemotherapy .
7833269	0	all-trans_retinoic_acid	67,90	interleukin-6	35,48	all-trans retinoic acid	interleukin-6	MESH:D014212	3569	Chemical	Gene	induced|nmod|START_ENTITY levels|acl|induced levels|amod|END_ENTITY	Hypercalcaemia and increased serum interleukin-6 levels induced by all-trans_retinoic_acid in patients with multiple_myeloma .
7949175	0	all-trans_retinoic_acid	21,44	interleukin-6	115,128	all-trans retinoic acid	interleukin-6	MESH:D014212	3569	Chemical	Gene	START_ENTITY|nmod|growth growth|nmod|cells cells|nmod|interference interference|nmod|transduction transduction|amod|END_ENTITY	Inhibitory effect of all-trans_retinoic_acid on the growth of freshly isolated myeloma cells via interference with interleukin-6 signal transduction .
11189515	0	all-trans_retinoic_acid	84,107	interleukin-8	15,28	all-trans retinoic acid	interleukin-8	MESH:D014212	3576	Chemical	Gene	-RSB-|amod|START_ENTITY Expression|nmod|-RSB- Expression|nmod|END_ENTITY	-LSB- Expression of interleukin-8 and its receptor in acute_promyelocytic_leukemia under all-trans_retinoic_acid treatment -RSB- .
7763262	0	all-trans_retinoic_acid	47,70	interleukin-8	14,27	all-trans retinoic acid	interleukin-8	MESH:D014212	3576	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of interleukin-8 gene expression by all-trans_retinoic_acid .
19357873	0	all-trans_retinoic_acid	10,33	matrix_metalloproteinase-2	58,84	all-trans retinoic acid	matrix metalloproteinase-2	MESH:D014212	81686(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|acl|END_ENTITY	Effect of all-trans_retinoic_acid on renal expressions of matrix_metalloproteinase-2 , matrix_metalloproteinase-9 and tissue_inhibitor_of_metalloproteinase-1 in rats with glomerulosclerosis .
12139725	0	all-trans_retinoic_acid	74,97	matrix_metalloproteinase-9	26,52	all-trans retinoic acid	matrix metalloproteinase-9	MESH:D014212	4318	Chemical	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	Simultaneous induction of matrix_metalloproteinase-9 and interleukin_8 by all-trans_retinoic_acid in human PL-21 and NB4 myeloid_leukaemia cells .
10664247	0	all-trans_retinoic_acid	11,34	nm23-H1	84,91	all-trans retinoic acid	nm23-H1	MESH:D014212	4830	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of all-trans_retinoic_acid and epidermal_growth_factor on the expression of nm23-H1 in human hepatocarcinoma cells .
26125906	0	all-trans_retinoic_acid	22,45	p38_MAPK	55,63	all-trans retinoic acid	p38 MAPK	MESH:D014212	26416(Tax:10090)	Chemical	Gene	acts|amod|START_ENTITY acts|nmod|END_ENTITY	WY14643 combined with all-trans_retinoic_acid acts via p38_MAPK to induce `` browning '' of white adipocytes in mice .
17962516	0	all-trans_retinoic_acid	42,65	pregnane_X_receptor	8,27	all-trans retinoic acid	pregnane X receptor	MESH:D014212	18171(Tax:10090)	Chemical	Gene	metabolism|amod|START_ENTITY Role|nmod|metabolism Role|nmod|END_ENTITY	Role of pregnane_X_receptor in control of all-trans_retinoic_acid -LRB- ATRA -RRB- metabolism and its potential contribution to ATRA resistance .
7998926	0	all-trans_retinoic_acid	34,57	retinoic_acid_receptor-beta	78,105	all-trans retinoic acid	retinoic acid receptor-beta	MESH:D014212	5915	Chemical	Gene	START_ENTITY|nmod|induction induction|nmod|END_ENTITY	Differential effects of 9-cis and all-trans_retinoic_acid on the induction of retinoic_acid_receptor-beta and cellular retinoic_acid-binding protein II in human neuroblastoma cells .
22686587	0	all-trans_retinoic_acid	10,33	syndecan-1	44,54	all-trans retinoic acid	syndecan-1	MESH:D014212	20969(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effect of all-trans_retinoic_acid -LRB- ATRA -RRB- on syndecan-1 expression and its chemoprotective effect in benzo -LRB- a -RRB- pyrene-induced lung_cancer mice model .
8822923	0	all-trans_retinoic_acid	43,66	thrombomodulin	14,28	all-trans retinoic acid	thrombomodulin	MESH:D014212	7056	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Regulation of thrombomodulin expression by all-trans_retinoic_acid and tumor_necrosis_factor-alpha : differential responses in keratinocytes and endothelial cells .
10866818	0	all-trans_retinoic_acid	102,125	tissue_inhibitor_of_metalloproteinases-1	33,73	all-trans retinoic acid	tissue inhibitor of metalloproteinases-1	MESH:D014212	7076	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Mechanisms of induction of human tissue_inhibitor_of_metalloproteinases-1 -LRB- TIMP-1 -RRB- gene expression by all-trans_retinoic_acid in combination with basic_fibroblast_growth_factor .
11389035	0	all-trans_retinoic_acid	112,135	vascular_endothelial_growth_factor	59,93	all-trans retinoic acid	vascular endothelial growth factor	MESH:D014212	7422	Chemical	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	Angiogenesis in acute_promyelocytic_leukemia : induction by vascular_endothelial_growth_factor and inhibition by all-trans_retinoic_acid .
19692509	0	allatostatin	76,88	AlstR	99,104	allatostatin	AlstR	MESH:C076523	44126(Tax:7227)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Transgenic silencing of neurons in the mammalian brain by expression of the allatostatin receptor -LRB- AlstR -RRB- .
11527383	0	allatostatin	96,108	DAR-1	120,125	allatostatin	DAR-1	MESH:C076523	38436(Tax:7227)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Type A allatostatins from Drosophila_melanogaster and Diplotera puncata activate two Drosophila allatostatin receptors , DAR-1 and DAR-2 , expressed in CHO cells .
8448153	0	allene_oxide	29,41	cytochrome_P450	70,85	allene oxide	cytochrome P450	null	4051	Chemical	Gene	synthase|compound|START_ENTITY END_ENTITY|nsubj|synthase	Low carbon_monoxide affinity allene_oxide synthase is the predominant cytochrome_P450 in many plant tissues .
19172254	0	allicin	11,18	CYP2C19	22,29	allicin	CYP2C19	MESH:C006452	1557	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|compound|END_ENTITY	Effects of allicin on CYP2C19 and CYP3A4 activity in healthy volunteers with different CYP2C19 genotypes .
9712340	0	allicin	10,17	inducible_nitric_oxide_synthase	58,89	allicin	inducible nitric oxide synthase	MESH:C006452	4843	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of allicin and ajoene , two compounds of garlic , on inducible_nitric_oxide_synthase .
16176143	0	allitridin	15,25	T-bet	69,74	allitridin	T-bet	MESH:C042577	57765(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of allitridin on the expression of transcription factors T-bet and GATA-3 in mice infected by murine_cytomegalovirus .
8497897	0	alloantigen	45,56	IL-2	0,4	alloantigen	IL-2	MESH:D007519	3558	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	IL-2 and IL-5 gene expression in response to alloantigen in liver allograft recipients and in vitro .
2383264	0	allodesmosine	64,77	elastin	99,106	allodesmosine	elastin	null	280781(Tax:9913)	Chemical	Gene	START_ENTITY|nmod|hydrolysate hydrolysate|nmod|END_ENTITY	Isolation and characterization of new cross-linking amino_acid `` allodesmosine '' from hydrolysate of elastin .
21118679	0	allopregnanolone	20,36	CA3	82,85	allopregnanolone	CA3	MESH:D011280	761	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|neurons neurons|compound|END_ENTITY	Multiple effects of allopregnanolone on GABAergic responses in single hippocampal CA3 pyramidal neurons .
9713333	0	allopregnanolone	24,40	gonadotropin-releasing_hormone	65,95	allopregnanolone	gonadotropin-releasing hormone	MESH:D011280	2796	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|release release|amod|END_ENTITY	The neuroactive steroid allopregnanolone suppresses hypothalamic gonadotropin-releasing_hormone release through a mechanism mediated by the gamma-aminobutyric_acidA receptor .
25140593	0	allopurinol	10,21	NGAL	78,82	allopurinol	NGAL	MESH:D000493	170496(Tax:10116)	Chemical	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Effect of allopurinol on the kidney function , histology and injury_biomarker -LRB- NGAL , IL_18 -RRB- levels in uninephrectomised rats subjected to ischaemia-reperfusion injury .
24248717	0	allopurinol	48,59	xanthine_dehydrogenase	63,85	allopurinol	xanthine dehydrogenase	MESH:D000493	7498	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Xanthine toxicity to caterpillars synergized by allopurinol , a xanthine_dehydrogenase / oxidase inhibitor .
8274161	1	allopurinol	156,167	xanthine_dehydrogenase	80,102	allopurinol	xanthine dehydrogenase	MESH:D000493	497811(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|oxidase oxidase|amod|END_ENTITY	Is xanthine_dehydrogenase or aldehyde oxidase more important in oxidizing both allopurinol and pyrazinamide ?
2823807	0	allopurinol	93,104	xanthine_oxidase	8,24	allopurinol	xanthine oxidase	MESH:D000493	100515259	Chemical	Gene	action|nmod|START_ENTITY mechanism|nmod|action Role|dep|mechanism Role|nmod|inhibitor inhibitor|amod|END_ENTITY	Role of xanthine_oxidase inhibitor as free radical scavenger : a novel mechanism of action of allopurinol and oxypurinol in myocardial salvage .
6897355	0	allopurinol	42,53	xanthine_oxidase	15,31	allopurinol	xanthine oxidase	MESH:D000493	22436(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Effects of the xanthine_oxidase inhibitor allopurinol on the renal clearance of nitroimidazoles .
19420714	0	allosamidin	109,120	Chitinase	0,9	allosamidin	Chitinase	MESH:C054851	818959(Tax:3702)	Chemical	Gene	enhances|nsubj|START_ENTITY stresses|parataxis|enhances stresses|nsubj|expression expression|amod|END_ENTITY	Chitinase gene expression in response to environmental stresses in Arabidopsis_thaliana : chitinase inhibitor allosamidin enhances stress tolerance .
20830981	0	alloxan	78,85	Catalase	0,8	alloxan	Catalase	MESH:D000496	24248(Tax:10116)	Chemical	Gene	levels|nmod|START_ENTITY levels|amod|END_ENTITY	Catalase activity , lipid peroxidation , cholesterol and triglyceride levels in alloxan -- induced diabetes_mellitus in female and male rats .
17867477	0	alloxan	74,81	insulin	56,63	alloxan	insulin	MESH:D000496	100009181(Tax:9986)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|compound|END_ENTITY	Effect of a compound recipe -LRB- medicinal plants -RRB- on serum insulin levels of alloxan induced diabetic rabbits .
24891878	0	alloxan	69,76	insulin	85,92	alloxan	insulin	MESH:D000496	3630	Chemical	Gene	model|compound|START_ENTITY model|compound|END_ENTITY	Blood glucose lowering activity of aloe based composition , UP780 , in alloxan induced insulin dependent mouse diabetes model .
3077897	0	alloxan	53,60	insulin	71,78	alloxan	insulin	MESH:D000496	105613195	Chemical	Gene	START_ENTITY|nmod|kinetics kinetics|compound|END_ENTITY	Experimental diabetes in lactating sheep : effects of alloxan on plasma insulin , glucose , glucose kinetics and milk characteristics .
6749587	0	alloxan	118,125	insulin	54,61	alloxan	insulin	MESH:D000496	483665(Tax:9615)	Chemical	Gene	dogs|amod|START_ENTITY Subcutaneous|nmod|dogs Subcutaneous|nmod|administration administration|nmod|END_ENTITY	Subcutaneous versus intraperitoneal administration of insulin on post-prandial hyperglycaemia and glucose_turnover in alloxan diabetic dogs .
7009825	0	alloxan	159,166	insulin	76,83	alloxan	insulin	MESH:D000496	100009181(Tax:9986)	Chemical	Gene	rats|amod|START_ENTITY administration|nmod|rats bases|nmod|administration END_ENTITY|nmod|bases	Pharmaceutical studies of polyacrylic_acid aqueous gel bases : absorption of insulin from polyacrylic_acid aqueous gel bases following rectal administration in alloxan diabetic rats and rabbits .
7026762	0	alloxan	78,85	insulin	61,68	alloxan	insulin	MESH:D000496	280829(Tax:9913)	Chemical	Gene	mice|amod|START_ENTITY level|nmod|mice level|compound|END_ENTITY	Effects of hypoglycemic components in ginseng radix on blood insulin level in alloxan diabetic mice and on insulin release from perfused rat pancreas .
321126	0	alloxan	10,17	pancreatic_polypeptide	25,47	alloxan	pancreatic polypeptide	MESH:D000496	24677(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of alloxan on rat pancreatic_polypeptide -LRB- PP -RRB- cells .
9215802	0	alloxan	146,153	thioltransferase	126,142	alloxan	thioltransferase	MESH:D000496	397463(Tax:9823)	Chemical	Gene	toxicity|compound|START_ENTITY END_ENTITY|nmod|toxicity	Glutathione dependent reduction of alloxan to dialuric_acid catalyzed by thioltransferase -LRB- glutaredoxin -RRB- : a possible role for thioltransferase in alloxan toxicity .
6933551	0	alloxan	23,30	thioredoxin	34,45	alloxan	thioredoxin	MESH:D000496	280950(Tax:9913)	Chemical	Gene	reduction|nmod|START_ENTITY reduction|nmod|END_ENTITY	Enzymatic reduction of alloxan by thioredoxin and NADPH-thioredoxin_reductase .
1897001	0	allyl_alcohol	10,23	xanthine_dehydrogenase	27,49	allyl alcohol	xanthine dehydrogenase	MESH:C006463	497811(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	Effect of allyl_alcohol on xanthine_dehydrogenase activity in the perfused rat liver .
7424328	0	allyl_isopropyl_acetamide	17,42	d-aminolevulinic_acid_synthetase	46,78	allyl isopropyl acetamide	d-aminolevulinic acid synthetase	MESH:D000502	211	Chemical	Gene	influence|nmod|START_ENTITY influence|nmod|END_ENTITY	The influence of allyl_isopropyl_acetamide on d-aminolevulinic_acid_synthetase and cytochrome_P-450 .
3737423	0	allyl_methyl_trisulfide	11,34	glutathione_S-transferase	38,63	allyl methyl trisulfide	glutathione S-transferase	MESH:C028526	54486(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|amod|END_ENTITY	Effects of allyl_methyl_trisulfide on glutathione_S-transferase activity and BP-induced neoplasia in the mouse .
24964313	0	allylarenes	83,94	C-H/C-H	53,60	allylarenes	C-H/C-H	null	91612	Chemical	Gene	coupling|nmod|START_ENTITY coupling|amod|END_ENTITY	Synergistic Pd/enamine catalysis : a strategy for the C-H/C-H oxidative coupling of allylarenes with unactivated ketones .
969796	0	allylestrenol	14,27	hpl	31,34	allylestrenol	hpl	MESH:D000500	3956	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	-LSB- Influence of allylestrenol on hpl serum levels in high-risk pregnancies -LRB- author 's transl -RRB- -RSB- .
26614409	0	allylidene_hydrazinecarboximidamide	54,89	BACE-1	105,111	allylidene hydrazinecarboximidamide	BACE-1	null	23621	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Rational design , synthesis and in vitro evaluation of allylidene_hydrazinecarboximidamide derivatives as BACE-1 inhibitors .
23523691	0	allylpyrocatechol	110,127	TNF-a	14,19	allylpyrocatechol	TNF-a	MESH:C523074	21926(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of TNF-a , and NF-kB and JNK pathways accounts for the prophylactic action of the natural phenolic , allylpyrocatechol against indomethacin gastropathy .
8819637	0	almitrine_bismesylate	50,71	renin	82,87	almitrine bismesylate	renin	MESH:D015765	101081695	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Effect of arterial chemoreceptor stimulation with almitrine_bismesylate on plasma renin activity , aldosterone , ACTH and cortisol in anaesthetized , artificially ventilated cats .
20843518	0	alogliptin	23,33	DPP-4	0,5	alogliptin	DPP-4	MESH:C520853	1803	Chemical	Gene	activation|amod|START_ENTITY inhibitor|dobj|activation inhibitor|nsubj|END_ENTITY	DPP-4 -LRB- CD26 -RRB- inhibitor alogliptin inhibits TLR4-mediated ERK activation and ERK-dependent MMP-1 expression by U937 histiocytes .
21558879	0	alogliptin	23,33	DPP-4	0,5	alogliptin	DPP-4	MESH:C520853	13482(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibitor|ccomp|inhibits inhibitor|nsubj|END_ENTITY	DPP-4 -LRB- CD26 -RRB- inhibitor alogliptin inhibits atherosclerosis in diabetic apolipoprotein_E-deficient mice .
22162539	0	alogliptin	120,130	DPP-4	71,76	alogliptin	DPP-4	MESH:C520853	1803	Chemical	Gene	meta-analysis|nmod|START_ENTITY model|dep|meta-analysis model|nmod|relationship relationship|nmod|inhibition inhibition|appos|END_ENTITY	Quantitative model of the relationship between dipeptidyl_peptidase-4 -LRB- DPP-4 -RRB- inhibition and response : meta-analysis of alogliptin , saxagliptin , sitagliptin , and vildagliptin efficacy results .
24225429	0	alogliptin	22,32	DPP-4	0,5	alogliptin	DPP-4	MESH:C520853	1803	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	DPP-4 inhibition with alogliptin on top of angiotensin_II_type_1_receptor blockade ameliorates albuminuria via up-regulation of SDF-1a in type 2 diabetic patients with incipient nephropathy .
24068868	0	alogliptin	71,81	Dipeptidyl_peptidase-4	0,22	alogliptin	Dipeptidyl peptidase-4	MESH:C520853	1803	Chemical	Gene	focus|nmod|START_ENTITY inhibitors|dep|focus inhibitors|amod|END_ENTITY	Dipeptidyl_peptidase-4 inhibitors in type 2 diabetes therapy -- focus on alogliptin .
20843518	0	alogliptin	23,33	ERK	57,60	alogliptin	ERK	MESH:C520853	5594	Chemical	Gene	activation|amod|START_ENTITY activation|compound|END_ENTITY	DPP-4 -LRB- CD26 -RRB- inhibitor alogliptin inhibits TLR4-mediated ERK activation and ERK-dependent MMP-1 expression by U937 histiocytes .
24843685	0	alogliptin	85,95	dipeptidyl-peptidase-4	51,73	alogliptin	dipeptidyl-peptidase-4	MESH:C520853	1803	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Efficacy of a-glucosidase inhibitors combined with dipeptidyl-peptidase-4 inhibitor -LRB- alogliptin -RRB- for glucose_fluctuation in patients with type __ 2_diabetes_mellitus by continuous glucose monitoring .
18499100	0	alogliptin	26,36	dipeptidyl_peptidase-4	76,98	alogliptin	dipeptidyl peptidase-4	MESH:C520853	13482(Tax:10090)	Chemical	Gene	administration|nmod|START_ENTITY administration|appos|inhibitor inhibitor|amod|END_ENTITY	Chronic administration of alogliptin , a novel , potent , and highly selective dipeptidyl_peptidase-4 inhibitor , improves glycemic control and beta-cell function in obese_diabetic_ob / ob_mice .
19371350	0	alogliptin	46,56	dipeptidyl_peptidase-4	12,34	alogliptin	dipeptidyl peptidase-4	MESH:C520853	13482(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Combining a dipeptidyl_peptidase-4 inhibitor , alogliptin , with pioglitazone improves glycaemic control , lipid profiles and beta-cell function in db/db mice .
19427871	0	alogliptin	42,52	dipeptidyl_peptidase-4	8,30	alogliptin	dipeptidyl peptidase-4	MESH:C520853	25253(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	A novel dipeptidyl_peptidase-4 inhibitor , alogliptin -LRB- SYR-322 -RRB- , is effective in diabetic rats with sulfonylurea-induced secondary failure .
22112254	0	alogliptin	25,35	dipeptidyl_peptidase-4	39,61	alogliptin	dipeptidyl peptidase-4	MESH:C520853	1803	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Clinical pharmacology of alogliptin , a dipeptidyl_peptidase-4 inhibitor , for the treatment of Type 2 diabetes .
22162539	0	alogliptin	120,130	dipeptidyl_peptidase-4	47,69	alogliptin	dipeptidyl peptidase-4	MESH:C520853	1803	Chemical	Gene	meta-analysis|nmod|START_ENTITY model|dep|meta-analysis model|nmod|relationship relationship|nmod|inhibition inhibition|amod|END_ENTITY	Quantitative model of the relationship between dipeptidyl_peptidase-4 -LRB- DPP-4 -RRB- inhibition and response : meta-analysis of alogliptin , saxagliptin , sitagliptin , and vildagliptin efficacy results .
23790558	0	alogliptin	54,64	dipeptidyl_peptidase-4	20,42	alogliptin	dipeptidyl peptidase-4	MESH:C520853	25253(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Orally administered dipeptidyl_peptidase-4 inhibitor -LRB- alogliptin -RRB- prevents abdominal_aortic_aneurysm formation through an antioxidant effect in rats .
23861159	0	alogliptin	12,22	dipeptidyl_peptidase-4	26,48	alogliptin	dipeptidyl peptidase-4	MESH:C520853	1803	Chemical	Gene	Efficacy|nmod|START_ENTITY Efficacy|appos|inhibitor inhibitor|amod|END_ENTITY	Efficacy of alogliptin , a dipeptidyl_peptidase-4 inhibitor , on glucose parameters , the activity of the advanced glycation end product -LRB- AGE -RRB- - receptor for AGE -LRB- RAGE -RRB- axis and albuminuria in Japanese type 2 diabetes .
17441705	0	alogliptin	13,23	dipeptidyl_peptidase_IV	89,112	alogliptin	dipeptidyl peptidase IV	MESH:C520853	1803	Chemical	Gene	Discovery|nmod|START_ENTITY Discovery|dep|inhibitor inhibitor|nmod|END_ENTITY	Discovery of alogliptin : a potent , selective , bioavailable , and efficacious inhibitor of dipeptidyl_peptidase_IV .
22512582	0	alogliptin	57,67	dipeptidyl_peptidase_IV	22,45	alogliptin	dipeptidyl peptidase IV	MESH:C520853	1803	Chemical	Gene	inhibitor|dep|START_ENTITY inhibitor|compound|END_ENTITY	Novel serine protease dipeptidyl_peptidase_IV inhibitor : alogliptin .
15915719	0	alpha-2-antiplasmin	47,66	plasmin	91,98	alpha-2-antiplasmin	plasmin	MESH:D000979	5340	Chemical	Gene	START_ENTITY|nmod|sites sites|nmod|END_ENTITY	-LSB- Effect of streptokinase on the interaction of alpha-2-antiplasmin with different sites of plasmin molecule -RSB- .
11399799	0	alpha-Chlorohydrin	0,18	glyceraldehyde-3-phosphate_dehydrogenase	28,68	alpha-Chlorohydrin	glyceraldehyde-3-phosphate dehydrogenase	MESH:D000517	2597	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	alpha-Chlorohydrin inhibits glyceraldehyde-3-phosphate_dehydrogenase in multiple organs as well as in sperm .
20378988	0	alpha-D-glucosylglycerol	34,58	insulin-like_growth_factor-i	79,107	alpha-D-glucosylglycerol	insulin-like growth factor-i	null	16000(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|nmod|END_ENTITY	Effects of topical application of alpha-D-glucosylglycerol on dermal levels of insulin-like_growth_factor-i in mice and on facial skin elasticity in humans .
8094315	0	alpha-Difluoromethylornithine	0,29	ornithine_decarboxylase	128,151	alpha-Difluoromethylornithine	ornithine decarboxylase	CHEBI:41948	24609(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|nmod|slices slices|nmod|effect effect|nmod|END_ENTITY	alpha-Difluoromethylornithine decreases inhibitory transmission in hippocampal slices independently of its inhibitory effect on ornithine_decarboxylase .
20636542	0	alpha-Gal	134,143	clusterin	167,176	alpha-Gal	clusterin	null	1191	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Resistance of neonatal porcine Sertoli cells to human xenoantibody and complement-mediated lysis is associated with low expression of alpha-Gal and high production of clusterin and CD59 .
1106109	0	alpha-L-fucose	67,81	LIF	59,62	alpha-L-fucose	LIF	CHEBI:42548	3976	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of human leukocyte_migration_inhibitory_factor -LRB- LIF -RRB- by alpha-L-fucose .
1106109	0	alpha-L-fucose	67,81	leukocyte_migration_inhibitory_factor	20,57	alpha-L-fucose	leukocyte migration inhibitory factor	CHEBI:42548	3976	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of human leukocyte_migration_inhibitory_factor -LRB- LIF -RRB- by alpha-L-fucose .
1671419	1	alpha-Methyltryptophan	50,72	gastrin	123,130	alpha-Methyltryptophan	gastrin	null	25320(Tax:10116)	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	alpha-Methyltryptophan derivatives as highly selective and orally active gastrin and CCK-B antagonists with potent anxiolytic properties .
11972286	0	alpha-Tocopherol	0,16	IL-8	26,30	alpha-Tocopherol	IL-8	MESH:D024502	3576	Chemical	Gene	synthesis|amod|START_ENTITY synthesis|compound|END_ENTITY	alpha-Tocopherol Inhibits IL-8 synthesis induced by thrombin and high glucose in endothelial cells .
20424383	0	alpha-Viniferin	0,15	signal_transducer_and_activation_of_transcription-1	31,82	alpha-Viniferin	signal transducer and activation of transcription-1	MESH:C064176	20846(Tax:10090)	Chemical	Gene	suppresses|amod|START_ENTITY suppresses|dep|END_ENTITY	alpha-Viniferin suppresses the signal_transducer_and_activation_of_transcription-1 -LRB- STAT-1 -RRB- - inducible inflammatory genes in interferon-gamma-stimulated macrophages .
17157019	0	alpha-acyl-beta-phenylpropanoic_acids	40,77	PPAR	81,85	alpha-acyl-beta-phenylpropanoic acids	PPAR	null	19013(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|agonists agonists|amod|END_ENTITY	Design and synthesis of oxime_ethers of alpha-acyl-beta-phenylpropanoic_acids as PPAR dual agonists .
15801832	0	alpha-alkyl_phenethylamines	19,46	MAO-A	75,80	alpha-alkyl phenethylamines	MAO-A	null	4128	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Sulfur-substituted alpha-alkyl_phenethylamines as selective and reversible MAO-A inhibitors : biological activities , CoMFA analysis , and active site modeling .
8907173	0	alpha-amino	17,28	neuropeptide_Y	38,52	alpha-amino	neuropeptide Y	null	4852	Chemical	Gene	group|amod|START_ENTITY group|nmod|END_ENTITY	Acylation of the alpha-amino group in neuropeptide_Y -LRB- 12-36 -RRB- increases binding affinity for the Y2 receptor .
14596864	0	alpha-amino-3-hydroxy-5-methyl-4-isoxazole_propionate	62,115	GluR1	33,38	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate	GluR1	null	50592(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY subunit|nmod|receptor subunit|amod|END_ENTITY	Increased phosphorylation of the GluR1 subunit of spinal cord alpha-amino-3-hydroxy-5-methyl-4-isoxazole_propionate receptor in rats following intradermal injection of capsaicin .
8960315	0	alpha-amino-3-hydroxy-5-methyl-4-isoxazole_propionate	28,81	GluR2	99,104	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate	GluR2	null	2891	Chemical	Gene	receptor|amod|START_ENTITY distribution|nmod|receptor subunit|nsubj|distribution subunit|dobj|END_ENTITY	Altered distribution of the alpha-amino-3-hydroxy-5-methyl-4-isoxazole_propionate receptor subunit GluR2 -LRB- 4 -RRB- and the N-methyl-D-aspartate receptor subunit NMDAR1 in the hippocampus of patients with temporal_lobe_epilepsy .
12471040	0	alpha-amino-3-hydroxy-5-methyl-4-isoxazole_propionate	58,111	GluR4	52,57	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate	GluR4	null	2893	Chemical	Gene	subunit|amod|START_ENTITY subunit|amod|END_ENTITY	Protein kinase C gamma associates directly with the GluR4 alpha-amino-3-hydroxy-5-methyl-4-isoxazole_propionate receptor subunit .
16606358	0	alpha-amino-3-hydroxy-5-methyl-4-isoxazole_propionic_acid	110,167	GluR1	104,109	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid	GluR1	MESH:D018350	2890	Chemical	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Direct interaction of post-synaptic density-95 / Dlg/ZO -1 domain-containing synaptic molecule Shank3 with GluR1 alpha-amino-3-hydroxy-5-methyl-4-isoxazole_propionic_acid receptor .
12909632	0	alpha-amino-3-hydroxy-5-methyl-4-isoxazole_propionic_acid	67,124	GluR2	61,66	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid	GluR2	MESH:D018350	2891	Chemical	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Characterization of the intracellular transport of GluR1 and GluR2 alpha-amino-3-hydroxy-5-methyl-4-isoxazole_propionic_acid receptor subunits in hippocampal neurons .
18289517	0	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate	8,60	GluR1	85,90	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate	GluR1	null	50592(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY Role|nmod|receptor subunit|nsubj|Role subunit|dobj|END_ENTITY	Role of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate -LRB- AMPA -RRB- receptor subunit GluR1 in spinal dorsal horn in inflammatory nociception and neuropathic_nociception in rat .
21832090	0	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic_acid	9,65	huntingtin	117,127	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid	huntingtin	MESH:D018350	15194(Tax:10090)	Chemical	Gene	receptor|nsubj|START_ENTITY receptor|nmod|END_ENTITY	Impaired alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic_acid -LRB- AMPA -RRB- receptor trafficking and function by mutant huntingtin .
12130635	0	alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic_acid	66,123	Brain-derived_neurotrophic_factor	0,33	alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid	Brain-derived neurotrophic factor	null	627	Chemical	Gene	receptors|amod|START_ENTITY expression|nmod|receptors regulates|dobj|expression regulates|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor regulates surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic_acid receptors by enhancing the N-ethylmaleimide-sensitive_factor / GluR2 interaction in developing neocortical neurons .
15090029	0	alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic_acid	14,71	GLUR2	8,13	alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid	GLUR2	null	14800(Tax:10090)	Chemical	Gene	subunit|amod|START_ENTITY subunit|compound|END_ENTITY	Loss of GLUR2 alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic_acid receptor subunit differentially affects remaining synaptic glutamate receptors in cerebellum and cochlear nuclei .
12676337	0	alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate	79,131	GluR1	58,63	alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate	GluR1	null	50592(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY subunit|nmod|receptor subunit|amod|END_ENTITY	Transient global ischemia enhances phosphorylation of the GluR1 subunit of the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor in the hippocampal CA1 region in rats .
11068135	0	alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate	28,80	GluR2	22,27	alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate	GluR2	null	14800(Tax:10090)	Chemical	Gene	subunit|amod|START_ENTITY subunit|amod|END_ENTITY	Long-term increase of GluR2 alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor subunit in the dispersed dentate gyrus after intrahippocampal kainate injection in the mouse .
19258522	0	alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic_acid	97,153	GluR1	91,96	alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid	GluR1	null	50592(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Activation of group I metabotropic glutamate receptors increases serine phosphorylation of GluR1 alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic_acid receptors in the rat dorsal striatum .
9677374	0	alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic_acid	29,85	GluR1	95,100	alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid	GluR1	null	50592(Tax:10116)	Chemical	Gene	subunit|amod|START_ENTITY subunit|compound|END_ENTITY	SAP97 is associated with the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic_acid receptor GluR1 subunit .
12070168	0	alpha-amino-5-hydroxy-3-methyl-4-isoxazole_propionate	61,114	GluR-A	54,60	alpha-amino-5-hydroxy-3-methyl-4-isoxazole propionate	GluR-A	null	2890	Chemical	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Selective binding of synapse-associated_protein_97 to GluR-A alpha-amino-5-hydroxy-3-methyl-4-isoxazole_propionate receptor subunit is determined by a novel sequence motif .
12070168	0	alpha-amino-5-hydroxy-3-methyl-4-isoxazole_propionate	61,114	synapse-associated_protein_97	21,50	alpha-amino-5-hydroxy-3-methyl-4-isoxazole propionate	synapse-associated protein 97	null	1739	Chemical	Gene	receptor|amod|START_ENTITY END_ENTITY|nmod|receptor	Selective binding of synapse-associated_protein_97 to GluR-A alpha-amino-5-hydroxy-3-methyl-4-isoxazole_propionate receptor subunit is determined by a novel sequence motif .
16759103	0	alpha-amino_amide	138,155	dipeptidyl_peptidase_IV	156,179	alpha-amino amide	dipeptidyl peptidase IV	null	1803	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	-LRB- 2S ,3 S -RRB- -3 - Amino-4 - -LRB- 3,3-difluoropyrrolidin-1-yl -RRB- - N,N-dimethyl-4-oxo-2 - -LRB- 4 - -LSB- 1,2,4 -RSB- triazolo -LSB- 1,5-a -RSB- - pyridin-6-ylphenyl -RRB- butanamide : a selective alpha-amino_amide dipeptidyl_peptidase_IV inhibitor for the treatment of type 2 diabetes .
5660636	1	alpha-aminoisobutyric_acid	81,107	insulin	70,77	alpha-aminoisobutyric acid	insulin	MESH:C100049	396145(Tax:9031)	Chemical	Gene	accumulation|amod|START_ENTITY effect|nmod|accumulation effect|nmod|END_ENTITY	The effect of insulin on alpha-aminoisobutyric_acid accumulation .
7655426	0	alpha-androstan-17-ones	54,77	C-6	128,131	alpha-androstan-17-ones	C-6	null	729	Chemical	Gene	START_ENTITY|nmod|function function|nmod|END_ENTITY	Biochemical studies of estr-4-ene-3 ,6,17 - trione and 5 alpha-androstan-17-ones with or without a carbonyl function at C-3 and/or C-6 as aromatase inhibitors .
25303458	0	alpha-arbutin	16,29	tyrosinase	86,96	alpha-arbutin	tyrosinase	null	7299	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Dual effects of alpha-arbutin on monophenolase and diphenolase activities of mushroom tyrosinase .
18704263	0	alpha-aryloxy-alpha-methylhydrocinnamic_acid	40,84	PPAR_gamma	100,110	alpha-aryloxy-alpha-methylhydrocinnamic acid	PPAR gamma	null	5468	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Antitumor activity of a novel series of alpha-aryloxy-alpha-methylhydrocinnamic_acid derivatives as PPAR_gamma agonists against a panel of human cancer cell lines .
15686898	0	alpha-asarone	52,65	HMG-CoA_reductase	96,113	alpha-asarone	HMG-CoA reductase	MESH:C012195	3156	Chemical	Gene	START_ENTITY|nmod|portion portion|nmod|END_ENTITY	Molecular docking of the highly hypolipidemic agent alpha-asarone with the catalytic portion of HMG-CoA_reductase .
12501200	0	alpha-bromoacetamidopropylestradiol	52,87	estrogen_receptor_alpha	117,140	alpha-bromoacetamidopropylestradiol	estrogen receptor alpha	null	13982(Tax:10090)	Chemical	Gene	sites|amod|START_ENTITY sites|nmod|END_ENTITY	Identification by MALDI-TOF mass spectrometry of 17 alpha-bromoacetamidopropylestradiol covalent attachment sites on estrogen_receptor_alpha .
11688517	0	alpha-difluoromethyl-ornithine	10,40	epidermal_growth_factor_receptor	79,111	alpha-difluoromethyl-ornithine	epidermal growth factor receptor	CHEBI:41948	1956	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effect of alpha-difluoromethyl-ornithine on the expression and function of the epidermal_growth_factor_receptor in human breast epithelial cells in culture .
7777588	11	alpha-difluoromethyl_ornithine	1798,1828	polyamine	1773,1782	alpha-difluoromethyl ornithine	prolactin	CHEBI:41948	5617	Chemical	Gene	synthesis|nmod|START_ENTITY synthesis|amod|END_ENTITY	However , inhibition of polyamine synthesis with alpha-difluoromethyl_ornithine or methylglyoxal_bis -LRB- guanylhydrazone -RRB- did not inhibit prolactin action .
16320593	0	alpha-difluoromethylornithine	11,40	ODC	62,65	alpha-difluoromethylornithine	ODC	CHEBI:41948	24609(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|mRNA mRNA|compound|END_ENTITY	-LSB- Effect of alpha-difluoromethylornithine on the expression of ODC mRNA in the cortex and hippocampus in rats after cerebral_ischemia reperfusion -RSB- .
1563337	0	alpha-difluoromethylornithine	101,130	Ornithine_decarboxylase	0,23	alpha-difluoromethylornithine	Ornithine decarboxylase	CHEBI:41948	4953	Chemical	Gene	effect|nmod|START_ENTITY induction|dep|effect induction|amod|END_ENTITY	Ornithine_decarboxylase induction and polyamine synthesis in the kindling of seizures : the effect of alpha-difluoromethylornithine .
19047162	0	alpha-difluoromethylornithine	38,67	Ornithine_decarboxylase	0,23	alpha-difluoromethylornithine	Ornithine decarboxylase	CHEBI:41948	4953	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Ornithine_decarboxylase inhibition by alpha-difluoromethylornithine activates opposing signaling pathways via phosphorylation of both Akt/protein _ kinase_B and p27Kip1 in neuroblastoma .
6809932	0	alpha-difluoromethylornithine	82,111	Ornithine_decarboxylase	0,23	alpha-difluoromethylornithine	Ornithine decarboxylase	CHEBI:41948	24609(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|dep|effects	Ornithine_decarboxylase and polyamines in tissues of the neonatal rat : effects of alpha-difluoromethylornithine , a specific , irreversible inhibitor of ornithine_decarboxylase .
3141298	3	alpha-difluoromethylornithine	513,542	TPN	504,507	alpha-difluoromethylornithine	ODC	CHEBI:41948	24609(Tax:10116)	Chemical	Gene	control|nmod|START_ENTITY control|nmod|END_ENTITY	In addition , we attempted to control tumor growth during TPN with alpha-difluoromethylornithine -LRB- DFMO -RRB- , a suicide inhibitor of ornithine_decarboxylase -LRB- ODC -RRB- , in a fibrosarcoma-bearing rat model .
10893799	0	alpha-difluoromethylornithine	11,40	cyclin_A	48,56	alpha-difluoromethylornithine	cyclin A	CHEBI:41948	890	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of alpha-difluoromethylornithine on the cyclin_A expression in Hep-2 cells .
3110101	0	alpha-difluoromethylornithine	14,43	interleukin_2	104,117	alpha-difluoromethylornithine	interleukin 2	CHEBI:41948	16183(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|production production|amod|END_ENTITY	The effect of alpha-difluoromethylornithine , an inhibitor of polyamine biosynthesis , on mitogen-induced interleukin_2 production .
1520332	0	alpha-difluoromethylornithine	67,96	ornithine_decarboxylase	12,35	alpha-difluoromethylornithine	ornithine decarboxylase	CHEBI:41948	4953	Chemical	Gene	Recovery|nmod|START_ENTITY Recovery|nmod|activity activity|amod|END_ENTITY	Recovery of ornithine_decarboxylase activity after inhibition with alpha-difluoromethylornithine .
1898085	0	alpha-difluoromethylornithine	86,115	ornithine_decarboxylase	7,30	alpha-difluoromethylornithine	ornithine decarboxylase	CHEBI:41948	4953	Chemical	Gene	selected|nmod|START_ENTITY selected|nsubj|END_ENTITY	Stable ornithine_decarboxylase in a rat hepatoma cell line selected for resistance to alpha-difluoromethylornithine .
1898373	0	alpha-difluoromethylornithine	124,153	ornithine_decarboxylase	10,33	alpha-difluoromethylornithine	ornithine decarboxylase	CHEBI:41948	4953	Chemical	Gene	Levels|amod|START_ENTITY Levels|nmod|sequences sequences|amod|END_ENTITY	Levels of ornithine_decarboxylase genomic sequences , heterogeneous nuclear RNA and mRNA in human myeloma cells resistant to alpha-difluoromethylornithine .
2424111	0	alpha-difluoromethylornithine	68,97	ornithine_decarboxylase	32,55	alpha-difluoromethylornithine	ornithine decarboxylase	CHEBI:41948	24609(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Inhibition of ileal and colonic ornithine_decarboxylase activity by alpha-difluoromethylornithine in rats : transient atrophic_changes and loss of postresectional adaptive growth .
2501085	0	alpha-difluoromethylornithine	106,135	ornithine_decarboxylase	22,45	alpha-difluoromethylornithine	ornithine decarboxylase	CHEBI:41948	18263(Tax:10090)	Chemical	Gene	cells|amod|START_ENTITY gene|nmod|cells Rearrangement|nmod|gene Rearrangement|nmod|END_ENTITY	Rearrangement between ornithine_decarboxylase and the switch region of the gamma 1 immunoglobulin gene in alpha-difluoromethylornithine resistant mouse myeloma cells .
2507897	0	alpha-difluoromethylornithine	21,50	ornithine_decarboxylase	69,92	alpha-difluoromethylornithine	ornithine decarboxylase	CHEBI:41948	4953	Chemical	Gene	changes|amod|START_ENTITY effect|nmod|changes effect|nmod|activity activity|amod|END_ENTITY	-LSB- Antitumor effect of alpha-difluoromethylornithine -LRB- DFMO -RRB- changes in ornithine_decarboxylase -LRB- ODC -RRB- activity and polyamine -LRB- PA -RRB- levels in human tumor transplanted into nude_mice -RSB- .
3096560	0	alpha-difluoromethylornithine	71,100	ornithine_decarboxylase	118,141	alpha-difluoromethylornithine	ornithine decarboxylase	CHEBI:41948	18263(Tax:10090)	Chemical	Gene	cells|nmod|START_ENTITY inhibition|nmod|cells Comparison|nmod|inhibition Comparison|appos|inhibitor inhibitor|nmod|spermidine spermidine|amod|END_ENTITY	Comparison and characterization of growth inhibition in L1210 cells by alpha-difluoromethylornithine , an inhibitor of ornithine_decarboxylase , and N1,N8-bis -LRB- ethyl -RRB- spermidine , an apparent regulator of the enzyme .
3100028	0	alpha-difluoromethylornithine	109,138	ornithine_decarboxylase	71,94	alpha-difluoromethylornithine	ornithine decarboxylase	CHEBI:41948	4953	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Decarboxylated-S-adenosylmethionine excretion : a biochemical marker of ornithine_decarboxylase inhibition by alpha-difluoromethylornithine .
3105526	0	alpha-difluoromethylornithine	19,48	ornithine_decarboxylase	52,75	alpha-difluoromethylornithine	ornithine decarboxylase	CHEBI:41948	4953	Chemical	Gene	Decarboxylation|nmod|START_ENTITY Decarboxylation|nmod|END_ENTITY	Decarboxylation of alpha-difluoromethylornithine by ornithine_decarboxylase .
3931903	0	alpha-difluoromethylornithine	65,94	ornithine_decarboxylase	14,37	alpha-difluoromethylornithine	ornithine decarboxylase	CHEBI:41948	18263(Tax:10090)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activity activity|amod|END_ENTITY	Inhibition of ornithine_decarboxylase activity by small doses of alpha-difluoromethylornithine .
6137572	0	alpha-difluoromethylornithine	10,39	ornithine_decarboxylase	57,80	alpha-difluoromethylornithine	ornithine decarboxylase	CHEBI:41948	4953	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Effect of alpha-difluoromethylornithine , an irreversible ornithine_decarboxylase inhibitor , on formation of GGTase-positive foci .
6208628	0	alpha-difluoromethylornithine	117,146	ornithine_decarboxylase	186,209	alpha-difluoromethylornithine	ornithine decarboxylase	CHEBI:41948	4953	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Control of nucleic acid and protein synthesis in developing brain , kidney , and heart of the neonatal rat : effects of alpha-difluoromethylornithine , a specific , irreversible inhibitor of ornithine_decarboxylase .
6217347	0	alpha-difluoromethylornithine	76,105	ornithine_decarboxylase	136,159	alpha-difluoromethylornithine	ornithine decarboxylase	CHEBI:41948	4953	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Role of polyamines in isoproterenol-induced cardiac_hypertrophy : effects of alpha-difluoromethylornithine , an irreversible inhibitor of ornithine_decarboxylase .
6442954	0	alpha-difluoromethylornithine	96,125	ornithine_decarboxylase	61,84	alpha-difluoromethylornithine	ornithine decarboxylase	CHEBI:41948	4953	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Successful treatment of lethal protozoal_infections with the ornithine_decarboxylase inhibitor , alpha-difluoromethylornithine .
6773783	0	alpha-difluoromethylornithine	46,75	ornithine_decarboxylase	106,129	alpha-difluoromethylornithine	ornithine decarboxylase	CHEBI:41948	18263(Tax:10090)	Chemical	Gene	development|nmod|START_ENTITY Inhibition|nmod|development Inhibition|appos|inhibitor inhibitor|nmod|END_ENTITY	Inhibition of murine embryonic development by alpha-difluoromethylornithine , an irreversible inhibitor of ornithine_decarboxylase .
6809932	0	alpha-difluoromethylornithine	82,111	ornithine_decarboxylase	151,174	alpha-difluoromethylornithine	ornithine decarboxylase	CHEBI:41948	24609(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Ornithine_decarboxylase and polyamines in tissues of the neonatal rat : effects of alpha-difluoromethylornithine , a specific , irreversible inhibitor of ornithine_decarboxylase .
6816220	0	alpha-difluoromethylornithine	155,184	ornithine_decarboxylase	29,52	alpha-difluoromethylornithine	ornithine decarboxylase	CHEBI:41948	4953	Chemical	Gene	Measurement|nmod|START_ENTITY Measurement|nmod|molecules molecules|amod|END_ENTITY	Measurement of the number of ornithine_decarboxylase molecules in rat and mouse tissues under various physiological conditions by binding of radiolabelled alpha-difluoromethylornithine .
7360002	0	alpha-difluoromethylornithine	88,117	ornithine_decarboxylase	148,171	alpha-difluoromethylornithine	ornithine decarboxylase	CHEBI:41948	4953	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Inhibition of EMT6 tumor growth by interference with polyamine biosynthesis ; effects of alpha-difluoromethylornithine , an irreversible inhibitor of ornithine_decarboxylase .
8221660	0	alpha-difluoromethylornithine	104,133	ornithine_decarboxylase	178,201	alpha-difluoromethylornithine	ornithine decarboxylase	CHEBI:41948	4953	Chemical	Gene	Development|nmod|START_ENTITY Development|nmod|subunit subunit|amod|END_ENTITY	Development of resistance to hydroxyurea during treatment of human myelogenous_leukemia K562 cells with alpha-difluoromethylornithine as a result of coamplification of genes for ornithine_decarboxylase and ribonucleotide reductase R2 subunit .
8801123	0	alpha-difluoromethylornithine	50,79	ornithine_decarboxylase	83,106	alpha-difluoromethylornithine	ornithine decarboxylase	CHEBI:41948	24609(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of gestational or neonatal treatment with alpha-difluoromethylornithine on ornithine_decarboxylase and polyamines in developing rat brain and on adult rat neurochemistry .
17912446	0	alpha-difluoromethylornithine	11,40	thrombospondin-1	44,60	alpha-difluoromethylornithine	thrombospondin-1	CHEBI:41948	7057	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|production production|amod|END_ENTITY	Effects of alpha-difluoromethylornithine on thrombospondin-1 production by human breast_cancer cells .
6144574	0	alpha-difluoromethylornithine	57,86	tissue_transglutaminase	30,53	alpha-difluoromethylornithine	tissue transglutaminase	CHEBI:41948	7052	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	The competitive inhibition of tissue_transglutaminase by alpha-difluoromethylornithine .
2143469	0	alpha-dihydroprogesterone	96,121	3_beta-hydroxysteroid_dehydrogenase	30,65	alpha-dihydroprogesterone	3 beta-hydroxysteroid dehydrogenase	null	3283	Chemical	Gene	concentrations|amod|START_ENTITY concentrations|amod|END_ENTITY	Effects of DHA-S on placental 3_beta-hydroxysteroid_dehydrogenase activity , progesterone and 20 alpha-dihydroprogesterone concentrations in placenta and serum .
9461660	0	alpha-dihydrotestosterone	27,52	sex_hormone-binding_globulin	70,98	alpha-dihydrotestosterone	sex hormone-binding globulin	null	6462	Chemical	Gene	START_ENTITY|xcomp|binding binding|nmod|END_ENTITY	Lignans interfering with 5 alpha-dihydrotestosterone binding to human sex_hormone-binding_globulin .
3118891	0	alpha-ethinylestradiol	13,35	apolipoprotein_A-I	82,100	alpha-ethinylestradiol	apolipoprotein A-I	null	25081(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of 17 alpha-ethinylestradiol on the catabolism of high-density lipoprotein apolipoprotein_A-I in the rat .
2238092	0	alpha-fluoromethylhistidine	16,43	histidine_decarboxylase	69,92	alpha-fluoromethylhistidine	histidine decarboxylase	null	3067	Chemical	Gene	Pharmacology|nmod|START_ENTITY Pharmacology|appos|inhibitor inhibitor|nmod|END_ENTITY	Pharmacology of alpha-fluoromethylhistidine , a specific inhibitor of histidine_decarboxylase .
3136625	0	alpha-fluoromethylhistidine	69,96	histidine_decarboxylase	122,145	alpha-fluoromethylhistidine	histidine decarboxylase	null	100719978	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Long-term depletion of histamine in guinea-pigs by administration of alpha-fluoromethylhistidine , a specific inhibitor of histidine_decarboxylase ; effect on the sensitivity of histamine receptors .
6645794	0	alpha-fluoromethylhistidine	25,52	histidine_decarboxylase	83,106	alpha-fluoromethylhistidine	histidine decarboxylase	null	24443(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Developmental effects of alpha-fluoromethylhistidine , an irreversible inhibitor of histidine_decarboxylase , on growth and on levels and turnover of catecholamines .
6830620	1	alpha-fluoromethylhistidine	107,134	histidine_decarboxylase	80,103	alpha-fluoromethylhistidine	histidine decarboxylase	null	24443(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of inhibition of histidine_decarboxylase by alpha-fluoromethylhistidine .
6855476	0	alpha-fluoromethylhistidine	11,38	histidine_decarboxylase	75,98	alpha-fluoromethylhistidine	histidine decarboxylase	null	24443(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|inhibitor inhibitor|nmod|END_ENTITY	Effects of alpha-fluoromethylhistidine -LRB- FMH -RRB- , an irreversible inhibitor of histidine_decarboxylase , on development of brain histamine and catecholamine systems in the neonatal rat .
10889161	0	alpha-galactosylceramide	40,64	CD1d	84,88	alpha-galactosylceramide	CD1d	MESH:C493154	12479(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|presence presence|nmod|END_ENTITY	Activation of natural killer T cells by alpha-galactosylceramide in the presence of CD1d provides protection against colitis in mice .
16007090	0	alpha-galactosylceramide	53,77	CD1d	31,35	alpha-galactosylceramide	CD1d	MESH:C493154	912	Chemical	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	The crystal structure of human CD1d with and without alpha-galactosylceramide .
17442335	0	alpha-galactosylceramide	98,122	CD1d	138,142	alpha-galactosylceramide	CD1d	MESH:C493154	12479(Tax:10090)	Chemical	Gene	START_ENTITY|acl|bound bound|nmod|END_ENTITY	Production and characterization of monoclonal antibodies against complexes of the NKT cell ligand alpha-galactosylceramide bound to mouse CD1d .
20624945	0	alpha-galactosylceramide	89,113	IFN_regulatory_factor_1	20,43	alpha-galactosylceramide	IFN regulatory factor 1	MESH:C493154	16362(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|role role|nmod|END_ENTITY	A critical role for IFN_regulatory_factor_1 in NKT cell-mediated liver_injury induced by alpha-galactosylceramide .
6269518	0	alpha-glycerophosphate	29,51	KOX-1	78,83	alpha-glycerophosphate	KOX-1	MESH:C029620	50490(Tax:10090)	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	-LSB- Effect of hydrocortisone on alpha-glycerophosphate dehydrogenase activity in KOX-1 and mouse_glioblastoma EPNT-5 cells -RSB- .
9812754	0	alpha-hederin	10,23	cytochrome_P-450	64,80	alpha-hederin	cytochrome P-450	MESH:C010177	13079(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of alpha-hederin and sapindoside_B on hepatic microsomal cytochrome_P-450 in mice .
18722115	0	alpha-hydroxy_amide	39,58	Bradykinin_B1_receptor	0,22	alpha-hydroxy amide	Bradykinin B1 receptor	null	623	Chemical	Gene	antagonists|dep|START_ENTITY antagonists|amod|END_ENTITY	Bradykinin_B1_receptor antagonists : an alpha-hydroxy_amide with an improved metabolism profile .
7582981	0	alpha-hydroxyacyl-prolyl-arginals	42,75	thrombin	21,29	alpha-hydroxyacyl-prolyl-arginals	thrombin	null	100009146(Tax:9986)	Chemical	Gene	inhibitors|dep|START_ENTITY inhibitors|compound|END_ENTITY	Active site-directed thrombin inhibitors : alpha-hydroxyacyl-prolyl-arginals .
6269831	0	alpha-hydroxycholecalciferol	51,79	parathyroid_hormone	83,102	alpha-hydroxycholecalciferol	parathyroid hormone	null	24694(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	Evidence for acute inhibitory effects in vivo of 1 alpha-hydroxycholecalciferol on parathyroid_hormone secretion in rats .
4068710	1	alpha-hydroxypregnene	54,75	C17-20	76,82	alpha-hydroxypregnene	C17-20	null	1035502(Tax:199310)	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	XX -- Effect of NADH on 17 alpha-hydroxypregnene C17-20 lyase activity .
3266311	0	alpha-hydroxyvitamin_D3	20,43	interleukin-2	47,60	alpha-hydroxyvitamin D3	interleukin-2	null	3558	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	In vivo effect of 1 alpha-hydroxyvitamin_D3 on interleukin-2 production in hemodialysis patients .
1439822	0	alpha-isopropylmalate	95,116	Leu3	79,83	alpha-isopropylmalate	Leu3	MESH:C005906	851172(Tax:4932)	Chemical	Gene	depends|nmod|START_ENTITY depends|nsubj|activation activation|nmod|END_ENTITY	In vitro transcriptional activation by a metabolic intermediate : activation by Leu3 depends on alpha-isopropylmalate .
10964677	0	alpha-keto-beta-aldehydes	24,49	cathepsin_S	71,82	alpha-keto-beta-aldehydes	cathepsin S	null	1520	Chemical	Gene	Evaluation|nmod|START_ENTITY Evaluation|nmod|END_ENTITY	Evaluation of dipeptide alpha-keto-beta-aldehydes as new inhibitors of cathepsin_S .
10694918	0	alpha-keto_acid	50,65	BCKDHA	102,108	alpha-keto acid	BCKDHA	null	593	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A nonsense mutation -LRB- R242X -RRB- in the branched-chain alpha-keto_acid dehydrogenase E1alpha subunit gene -LRB- BCKDHA -RRB- as a cause of maple_syrup_urine_disease .
8312380	0	alpha-keto_acid	56,71	E1_beta_subunit	18,33	alpha-keto acid	E1 beta subunit	null	594	Chemical	Gene	complex|amod|START_ENTITY END_ENTITY|nmod|complex	Deficiency of the E1_beta_subunit in the branched-chain alpha-keto_acid dehydrogenase complex due to a single base substitution of the intron 5 , resulting in two alternatively spliced mRNAs in a patient with maple_syrup_urine_disease .
2393300	0	alpha-keto_esters	49,66	cathepsin_B	14,25	alpha-keto esters	cathepsin B	CHEBI:51848	1508	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of cathepsin_B and papain by peptidyl alpha-keto_esters , alpha-keto_amides , alpha-diketones , and alpha-keto_acids .
2322554	0	alpha-ketoacid	120,134	E1_beta_subunit	75,90	alpha-ketoacid	E1 beta subunit	null	594	Chemical	Gene	complex|amod|START_ENTITY END_ENTITY|nmod|complex	Isolation and characterization of a complementary DNA clone coding for the E1_beta_subunit of the bovine branched-chain alpha-ketoacid dehydrogenase complex : complete amino_acid sequence of the precursor protein and its proteolytic processing .
26178471	0	alpha-ketoglutarate	17,36	D2HGDH	0,6	alpha-ketoglutarate	D2HGDH	MESH:C029743	728294	Chemical	Gene	levels|amod|START_ENTITY regulates|dobj|levels regulates|nsubj|END_ENTITY	D2HGDH regulates alpha-ketoglutarate levels and dioxygenase function by modulating IDH2 .
12524404	9	alpha-ketoglutarate	1435,1454	glutamine	1411,1420	alpha-ketoglutarate	TNF-alpha	MESH:C029743	7124	Chemical	Gene	conversion|nmod|START_ENTITY conversion|amod|END_ENTITY	Inhibition of glutamine conversion to alpha-ketoglutarate , but not blockade of glutathione or polyamine synthesis , also induced translocation in the presence of TNF-alpha .
2899080	0	alpha-ketoglutarate	67,86	malate_dehydrogenase	14,34	alpha-ketoglutarate	malate dehydrogenase	MESH:C029743	4200	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|activity activity|amod|END_ENTITY	Regulation of malate_dehydrogenase activity by glutamate , citrate , alpha-ketoglutarate , and multienzyme interaction .
14563831	0	alpha-linolenic_acid	8,28	COX-2	37,42	alpha-linolenic acid	COX-2	MESH:D017962	26198(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|compound|END_ENTITY	Dietary alpha-linolenic_acid reduces COX-2 expression and induces apoptosis of hepatoma cells .
17134970	0	alpha-linolenic_acid	74,94	HER2	0,4	alpha-linolenic acid	HER2	MESH:D017962	2064	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|dep|effects	HER2 -LRB- erbB-2 -RRB- - targeted effects of the omega-3_polyunsaturated_fatty_acid , alpha-linolenic_acid -LRB- ALA ; 18:3 n-3 -RRB- , in breast_cancer cells : the `` fat features '' of the `` Mediterranean diet '' as an `` anti-HER2 cocktail '' .
16197574	0	alpha-linolenic_acid	53,73	Min	133,136	alpha-linolenic acid	Min	MESH:D017962	11789(Tax:10090)	Chemical	Gene	mice|amod|START_ENTITY mice|appos|END_ENTITY	Effects of a flaxseed mixture and plant oils rich in alpha-linolenic_acid on the adenoma formation in multiple_intestinal_neoplasia -LRB- Min -RRB- mice .
9610840	0	alpha-linolenic_acid	8,28	TNF-alpha	39,48	alpha-linolenic acid	TNF-alpha	MESH:D017962	21926(Tax:10090)	Chemical	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	Dietary alpha-linolenic_acid increases TNF-alpha , and decreases IL-6 , IL-10 in response to LPS : effects of sesamin on the delta-5 desaturation of omega6 and omega3 fatty_acids in mice .
1675843	0	alpha-linolenic_acid	18,38	tumor_necrosis_factor	74,95	alpha-linolenic acid	tumor necrosis factor	MESH:D017962	100033834(Tax:9796)	Chemical	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	Effect of dietary alpha-linolenic_acid on endotoxin-induced production of tumor_necrosis_factor by peritoneal macrophages in horses .
20580704	0	alpha-lipoic_acid	24,41	Kip1	54,58	alpha-lipoic acid	Kip1	MESH:D008063	1027	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	The natural antioxidant alpha-lipoic_acid induces p27 -LRB- Kip1 -RRB- - dependent cell cycle arrest and apoptosis in MCF-7 human breast_cancer cells .
16706642	0	alpha-lipoic_acid	23,40	acetylcholinesterase	44,64	alpha-lipoic acid	acetylcholinesterase	MESH:D008063	83817(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Protective efficacy of alpha-lipoic_acid on acetylcholinesterase activity in aged rat brain regions .
8179594	0	alpha-lipoic_acid	11,28	c-fos	84,89	alpha-lipoic acid	c-fos	MESH:D008063	2353	Chemical	Gene	Effects|acl|START_ENTITY Effects|nmod|END_ENTITY	Effects of alpha-lipoic_acid and dihydrolipoic_acid on expression of proto-oncogene c-fos .
26721419	0	alpha-lipoic_acid	11,28	chemerin	32,40	alpha-lipoic acid	chemerin	MESH:D008063	5919	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Effects of alpha-lipoic_acid on chemerin secretion in 3T3-L1 and human adipocytes .
16166554	0	alpha-lipoic_acid	21,38	fractalkine	81,92	alpha-lipoic acid	fractalkine	MESH:D008063	6376	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nsubj|effect	Protective effect of alpha-lipoic_acid in lipopolysaccharide-induced endothelial fractalkine expression .
22212728	0	alpha-lipoic_acid	0,17	iNOS	44,48	alpha-lipoic acid	iNOS	MESH:D008063	24599(Tax:10116)	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|dobj|induction induction|nmod|expression expression|amod|END_ENTITY	alpha-lipoic_acid prevents the induction of iNOS gene expression through destabilization of its mRNA in proinflammatory cytokine-stimulated hepatocytes .
7753406	0	alpha-methyl	124,136	MAP4	167,171	alpha-methyl	MAP4	null	367171(Tax:10116)	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Distinct presynaptic metabotropic receptors for L-AP4 and CCG1 on GABAergic terminals : pharmacological evidence using novel alpha-methyl derivative mGluR antagonists , MAP4 and MCCG , in the rat thalamus in vivo .
3335544	0	alpha-methyl	57,69	demethylase	70,81	alpha-methyl	demethylase	null	8932	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	A mammalian mutant cell lacking detectable lanosterol 14 alpha-methyl demethylase activity .
4158803	0	alpha-methyl-tyrosine	50,71	tyrosine_hydroxylase	89,109	alpha-methyl-tyrosine	tyrosine hydroxylase	D019805	7054	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Inhibition of catecholamine synthesis in man with alpha-methyl-tyrosine , an inhibitor of tyrosine_hydroxylase .
629941	0	alpha-methylornithine	56,77	ornithine_decarboxylase	29,52	alpha-methylornithine	ornithine decarboxylase	null	4953	Chemical	Gene	Mechanism|nmod|START_ENTITY Mechanism|nmod|END_ENTITY	Mechanism of inactivation of ornithine_decarboxylase by alpha-methylornithine .
7821774	0	alpha-methyltestosterone	68,92	gonadotropin-releasing_hormone	21,51	alpha-methyltestosterone	gonadotropin-releasing hormone	null	2796	Chemical	Gene	administration|amod|START_ENTITY END_ENTITY|nmod|administration	Activation of salmon gonadotropin-releasing_hormone synthesis by 17 alpha-methyltestosterone administration in yearling masu salmon , Oncorhynchus masou .
7160183	0	alpha-monofluoromethyl_histidine	10,42	histidine_decarboxylase	73,96	alpha-monofluoromethyl histidine	histidine decarboxylase	null	15186(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|inhibitor inhibitor|nmod|END_ENTITY	Effect of alpha-monofluoromethyl_histidine , an irreversible inhibitor of histidine_decarboxylase , on gestation in mice .
8390116	0	alpha-naphthoflavone	23,43	Ah_receptor	50,61	alpha-naphthoflavone	Ah receptor	MESH:C011512	196	Chemical	Gene	START_ENTITY|nmod|antagonist antagonist|compound|END_ENTITY	Mechanism of action of alpha-naphthoflavone as an Ah_receptor antagonist in MCF-7 human breast_cancer cells .
2359409	0	alpha-naphthoflavone	36,56	cytochrome_P-450c	15,32	alpha-naphthoflavone	cytochrome P-450c	MESH:C011512	24296(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY END_ENTITY|nmod|metabolism	Involvement of cytochrome_P-450c in alpha-naphthoflavone metabolism by rat liver microsomes .
12758162	0	alpha-naphthoflavone	28,48	cytochrome_P450_1A2	58,77	alpha-naphthoflavone	cytochrome P450 1A2	MESH:C011512	1544	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Tight-binding inhibition by alpha-naphthoflavone of human cytochrome_P450_1A2 .
10022752	0	alpha-naphthoflavone	129,149	cytochrome_P450_3A	6,24	alpha-naphthoflavone	cytochrome P450 3A	MESH:C011512	1576	Chemical	Gene	mediated|nmod|START_ENTITY mediated|nsubj|END_ENTITY	Human cytochrome_P450_3A -LRB- CYP3A -RRB- mediated midazolam metabolism : the effect of assay conditions and regioselective stimulation by alpha-naphthoflavone , terfenadine and testosterone .
15598703	0	alpha-naphthyl_isothiocyanate	11,40	PhIP	67,71	alpha-naphthyl isothiocyanate	PhIP	MESH:D015058	315843(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of alpha-naphthyl_isothiocyanate and a_heterocyclic_amine , PhIP , on cytochrome_P-450 , mutagenic activation of various carcinogens and glucuronidation in rat liver .
15598703	0	alpha-naphthyl_isothiocyanate	11,40	cytochrome_P-450	76,92	alpha-naphthyl isothiocyanate	cytochrome P-450	MESH:D015058	25251(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activation activation|amod|END_ENTITY	Effects of alpha-naphthyl_isothiocyanate and a_heterocyclic_amine , PhIP , on cytochrome_P-450 , mutagenic activation of various carcinogens and glucuronidation in rat liver .
15176077	0	alpha-naphthyl_isothiocyanates	36,66	P-glycoprotein	70,84	alpha-naphthyl isothiocyanates	P-glycoprotein	null	5243	Chemical	Gene	START_ENTITY|nmod|transport transport|amod|END_ENTITY	Effects of benzyl - , phenethyl - , and alpha-naphthyl_isothiocyanates on P-glycoprotein - and MRP1-mediated transport .
8971961	0	alpha-naphthylthiourea	55,77	endothelin-1	16,28	alpha-naphthylthiourea	endothelin-1	MESH:C005277	24323(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|effect effect|nmod|END_ENTITY	Acute effect of endothelin-1 on lung_oedema induced by alpha-naphthylthiourea -LRB- ANTU -RRB- .
11705697	0	alpha-phenyl-N-tert-butyl-nitron	23,55	caspase-3	65,74	alpha-phenyl-N-tert-butyl-nitron	caspase-3	null	25402(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	Free radical spin trap alpha-phenyl-N-tert-butyl-nitron inhibits caspase-3 activation and reduces brain_damage following a severe forebrain_ischemic_injury .
8619865	0	alpha-phenyl-tert-butylnitrone	133,163	gp_120	103,109	alpha-phenyl-tert-butylnitrone	gp 120	MESH:C029217	155971(Tax:11676)	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|dep|effects	In vivo trapping of nitric_oxide in the brain of neonatal rats treated with the HIV-1 envelope protein gp_120 : protective effects of alpha-phenyl-tert-butylnitrone .
11042381	0	alpha-rubromycin	61,77	DNA_polymerase_beta	38,57	alpha-rubromycin	DNA polymerase beta	MESH:C064946	5423	Chemical	Gene	mode|nmod|START_ENTITY mode|nmod|END_ENTITY	The biochemical mode of inhibition of DNA_polymerase_beta by alpha-rubromycin .
12582025	0	alpha-santalol	27,41	CD-1	71,75	alpha-santalol	CD-1	CHEBI:10330	111334(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|mice mice|compound|END_ENTITY	Chemopreventive effects of alpha-santalol on skin_tumor development in CD-1 and SENCAR mice .
21493063	0	alpha-sulfone_hydroxamates	17,43	MMP-13	0,6	alpha-sulfone hydroxamates	MMP-13	null	4322	Chemical	Gene	START_ENTITY|amod|selective selective|amod|END_ENTITY	MMP-13 selective alpha-sulfone_hydroxamates : identification of selective P1 ' amides .
12562825	0	alpha-tetrahydroxy-5_beta-cholan-24-oic_acid	48,92	spgp	96,100	alpha-tetrahydroxy-5 beta-cholan-24-oic acid	spgp	null	27413(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|compound|END_ENTITY	Appearance of atypical 3 alpha ,6 beta ,7 beta ,12 alpha-tetrahydroxy-5_beta-cholan-24-oic_acid in spgp knockout mice .
15780763	0	alpha-tocopherol	68,84	CD36	0,4	alpha-tocopherol	CD36	MESH:D024502	948	Chemical	Gene	reversed|nmod|START_ENTITY reversed|nsubjpass|overexpression overexpression|nummod|END_ENTITY	CD36 overexpression in ritonavir-treated THP-1 cells is reversed by alpha-tocopherol .
16407258	0	alpha-tocopherol	61,77	CD36	81,85	alpha-tocopherol	CD36	MESH:D024502	948	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Antagonistic effects of oxidized low density lipoprotein and alpha-tocopherol on CD36 scavenger receptor expression in monocytes : involvement of protein_kinase_B and peroxisome_proliferator-activated_receptor-gamma .
19766176	0	alpha-tocopherol	25,41	ERK1/2	113,119	alpha-tocopherol	ERK1/2	MESH:D024502	50689;116590	Chemical	Gene	effect|nmod|START_ENTITY mediated|nsubjpass|effect mediated|nmod|END_ENTITY	The protective effect of alpha-tocopherol against dichromate-induced renal tight junction damage is mediated via ERK1/2 .
8878940	0	alpha-tocopherol	16,32	HDL3	36,40	alpha-tocopherol	HDL3	MESH:D024502	53369	Chemical	Gene	Contribution|nmod|START_ENTITY Contribution|nmod|END_ENTITY	Contribution of alpha-tocopherol in HDL3 to inhibition of LDL oxidation by human macrophages .
3630966	0	alpha-tocopherol	108,124	IRBP	88,92	alpha-tocopherol	IRBP	MESH:D024502	5949	Chemical	Gene	transport|amod|START_ENTITY END_ENTITY|nmod|transport	Levels of alpha - _ and_gamma-tocopherol in human eyes : evaluation of the possible role of IRBP in intraocular alpha-tocopherol transport .
11922755	0	alpha-tocopherol	100,116	alpha-tocopherol_transfer_protein	46,79	alpha-tocopherol	alpha-tocopherol transfer protein	MESH:D024502	7274	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression and refolding of recombinant human alpha-tocopherol_transfer_protein capable of specific alpha-tocopherol binding .
9178827	0	alpha-tocopherol	87,103	alpha-tocopherol_transfer_protein	42,75	alpha-tocopherol	alpha-tocopherol transfer protein	MESH:D024502	25571(Tax:10116)	Chemical	Gene	Correlation|nmod|START_ENTITY Correlation|nmod|transcription transcription|nmod|END_ENTITY	Correlation of repressed transcription of alpha-tocopherol_transfer_protein with serum alpha-tocopherol during hepatocarcinogenesis .
9356467	0	alpha-tocopherol	62,78	alpha-tocopherol_transfer_protein	0,33	alpha-tocopherol	alpha-tocopherol transfer protein	MESH:D024502	7274	Chemical	Gene	secretion|nmod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	alpha-tocopherol_transfer_protein stimulates the secretion of alpha-tocopherol from a cultured liver cell line through a brefeldin_A-insensitive pathway .
12669955	0	alpha-tocopherol	24,40	apolipoprotein_B	44,60	alpha-tocopherol	apolipoprotein B	MESH:D024502	238055(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Disposition kinetics of alpha-tocopherol in apolipoprotein_B knockout mice .
5879474	0	alpha-tocopherol	17,33	arylsulfatases_A_and_B	37,59	alpha-tocopherol	arylsulfatases A and B	MESH:D024502	315222;25227	Chemical	Gene	influence|nmod|START_ENTITY influence|nmod|END_ENTITY	The influence of alpha-tocopherol on arylsulfatases_A_and_B in the liver of vitamin_A-deficient rats .
15665910	0	alpha-tocopherol	55,71	cytochrome_P450_1A1	30,49	alpha-tocopherol	cytochrome P450 1A1	MESH:D024502	24296(Tax:10116)	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Transcriptional activation of cytochrome_P450_1A1 with alpha-tocopherol .
6111389	0	alpha-tocopherol	27,43	gamma-glutamyltranspeptidase	47,75	alpha-tocopherol	gamma-glutamyltranspeptidase	MESH:D024502	116568(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effects of dietary fat and alpha-tocopherol on gamma-glutamyltranspeptidase activity of 7 , _ 12-dimethylbenz -LRB- alpha -RRB- anthracene-induced mammary_gland_adenocarcinomas .
7582866	0	alpha-tocopherol	21,37	leukocyte_elastase	60,78	alpha-tocopherol	leukocyte elastase	MESH:D024502	1991	Chemical	Gene	Relationship|nmod|START_ENTITY END_ENTITY|nsubj|Relationship	Relationship between alpha-tocopherol and polymorphonuclear leukocyte_elastase in septic adult_respiratory_distress_syndrome .
2629610	0	alpha-tocopherol	53,69	low_density_lipoprotein_receptor	16,48	alpha-tocopherol	low density lipoprotein receptor	MESH:D024502	100009086(Tax:9986)	Chemical	Gene	delivery|amod|START_ENTITY END_ENTITY|nmod|delivery	The role of the low_density_lipoprotein_receptor for alpha-tocopherol delivery to tissues .
9457740	0	alpha-tocopherol	100,116	p53	66,69	alpha-tocopherol	p53	MESH:D024502	22060(Tax:10090)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|gene gene|compound|END_ENTITY	Inhibition of cyclobutane_pyrimidine_dimer formation in epidermal p53 gene of UV-irradiated mice by alpha-tocopherol .
10924325	0	alpha-tocopherol	24,40	vascular_cell_adhesion_molecule-1	44,77	alpha-tocopherol	vascular cell adhesion molecule-1	MESH:D024502	7412	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Selective inhibition by alpha-tocopherol of vascular_cell_adhesion_molecule-1 expression in human vascular endothelial cells .
8298498	0	alpha-tocopheryl_succinate	49,75	NF-kappa_B	14,24	alpha-tocopheryl succinate	NF-kappa B	null	4790	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Inhibition of NF-kappa_B DNA binding activity by alpha-tocopheryl_succinate .
20193368	0	alpha-zearalanol	11,27	HO-1	51,55	alpha-zearalanol	HO-1	null	3162	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|gene gene|compound|END_ENTITY	-LSB- Effect of alpha-zearalanol upon the expression of HO-1 gene and the cytosolic free calcium level in tumor_necrosis_factor_alpha-stimulated human endothelial cell -RSB- .
17900592	0	alpha-zearalanol	14,30	endothelin-1	61,73	alpha-zearalanol	endothelin-1	null	1906	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Phytoestrogen alpha-zearalanol inhibits homocysteine-induced endothelin-1 expression and oxidative stress in human umbilical vein endothelial cells .
16370314	0	alpha-zearalenol	22,38	integrin_beta3	65,79	alpha-zearalenol	integrin beta3	MESH:C029659	3690	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|mRNA mRNA|amod|END_ENTITY	Inhibitory effects of alpha-zearalenol on angiotensin_II-induced integrin_beta3 mRNA via suppression of nuclear factor-kappaB .
16184762	0	alphaB-crystallin	27,44	CRYAB	140,145	alphaB-crystallin	CRYAB	null	1410	Chemical	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Differential expression of alphaB-crystallin and Hsp27-1 in anaplastic thyroid_carcinomas because of tumor-specific alphaB-crystallin gene -LRB- CRYAB -RRB- silencing .
19205872	0	alphaB-crystallin	14,31	Ets1	76,80	alphaB-crystallin	Ets1	null	2113	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Regulation of alphaB-crystallin gene expression by the transcription factor Ets1 in breast_cancer .
12217423	0	alphaMSH	71,79	alpha_melanocyte_stimulating_hormone	33,69	alphaMSH	alpha melanocyte stimulating hormone	MESH:D000521	24664(Tax:10116)	Chemical	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	The effects of acute and chronic alpha_melanocyte_stimulating_hormone -LRB- alphaMSH -RRB- on cardiovascular dynamics in conscious rats .
24349086	0	alpha_linolenic_acid	10,30	prostate_specific_antigen	56,81	alpha linolenic acid	prostate specific antigen	MESH:D017962	354	Chemical	Gene	supplementation|amod|START_ENTITY supplementation|nmod|END_ENTITY	Effect of alpha_linolenic_acid supplementation on serum prostate_specific_antigen -LRB- PSA -RRB- : results from the alpha omega trial .
10095798	0	alphacalcidol	39,52	L-1	108,111	alphacalcidol	L-1	MESH:C008088	16728(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Long-term effects of intermittent oral alphacalcidol , calcium_carbonate and low-calcium dialysis -LRB- 1.25 mmol L-1 -RRB- on secondary_hyperparathyroidism in patients on continuous ambulatory peritoneal dialysis .
3028070	0	alphanapthylthiourea	14,34	angiotensin_converting_enzyme	94,123	alphanapthylthiourea	angiotensin converting enzyme	null	24310(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of alphanapthylthiourea -LRB- ANTU -RRB- - induced acute_injury on lung binding of antibody to angiotensin_converting_enzyme -LRB- ACE -RRB- .
8646822	0	alprazolam	36,46	CYP3A4	128,134	alprazolam	CYP3A4	MESH:D000525	1576	Chemical	Gene	START_ENTITY|nmod|evidence evidence|nmod|involvement involvement|nmod|END_ENTITY	A kinetic and dynamic study of oral alprazolam with and without erythromycin in humans : in vivo evidence for the involvement of CYP3A4 in alprazolam metabolism .
2575286	0	alprazolam	17,27	corticotropin-releasing_factor	68,98	alprazolam	corticotropin-releasing factor	MESH:D000525	81648(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|concentrations concentrations|nmod|END_ENTITY	Acute effects of alprazolam and adinazolam on the concentrations of corticotropin-releasing_factor in the rat brain .
6531653	0	alprenolol	14,24	myoglobin	34,43	alprenolol	myoglobin	MESH:D000526	4151	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|levels levels|compound|END_ENTITY	The effect of alprenolol on serum myoglobin levels in acute_myocardial_infarction .
1199814	0	alprenolol	10,20	renin	47,52	alprenolol	renin	MESH:D000526	5972	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|concentration concentration|compound|END_ENTITY	Effect of alprenolol and hydralazine on plasma renin concentration in patients with arterial hypertension .
15951350	0	alprostadil	12,23	VEGF	32,36	alprostadil	VEGF	MESH:D000527	7422	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	PGE1 analog alprostadil induces VEGF and eNOS expression in endothelial cells .
19770537	9	alprostadil	1214,1225	VEGF	1243,1247	alprostadil	VEGF	MESH:D000527	83785(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	The effects of alprostadil on expression of VEGF , repair of neural pathology , and recovery of neural function were also evaluated .
26267685	0	alprostadil	11,22	miRNA-155	41,50	alprostadil	miRNA-155	MESH:D000527	406947	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Effect of alprostadil on serum level of miRNA-155 in uremic patients -RSB- .
6787107	0	alrestatin	14,24	insulin	58,65	alrestatin	insulin	MESH:C016212	3630	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|release release|nmod|END_ENTITY	The effect of alrestatin on alanine-stimulated release of insulin and glucagon in man .
744568	0	alrestatin_sodium	10,27	insulin	50,57	alrestatin sodium	insulin	null	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of alrestatin_sodium on glucose-stimulated insulin secretion in the fasted anaesthetized rat .
2568474	0	altiopril_calcium	91,108	angiotensin_converting_enzyme	27,56	altiopril calcium	angiotensin converting enzyme	null	24310(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nmod|effect	Contribution of the tissue angiotensin_converting_enzyme to the antihypertensive effect of altiopril_calcium -LRB- MC-838 -RRB- in spontaneously hypertensive rats .
22009450	0	aluminium	36,45	CO2	29,32	aluminium	CO2	CHEBI:28984	717	Chemical	Gene	levels|compound|START_ENTITY END_ENTITY|nmod|levels	Linking groundwaters of high CO2 to aluminium levels in rivers : the case for the upper Severn in mid-Wales .
24446331	0	aluminium	14,23	CO2	79,82	aluminium	CO2	CHEBI:28984	717	Chemical	Gene	catalysts|nsubj|START_ENTITY catalysts|nmod|END_ENTITY	Highly active aluminium catalysts for the formation of organic carbonates from CO2 and oxiranes .
19490502	1	aluminium	60,69	TaALMT1	87,94	aluminium	TaALMT1	CHEBI:28984	543388(Tax:4565)	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	expressing the wheat aluminium resistance gene -LRB- TaALMT1 -RRB- shows enhanced phosphorus nutrition and grain production when grown on an acid soil .
20338951	0	aluminium	20,29	TaALMT1	69,76	aluminium	TaALMT1	CHEBI:28984	543388(Tax:4565)	Chemical	Gene	resistance|compound|START_ENTITY resistance|nmod|wheat wheat|nmod|END_ENTITY	Engineering greater aluminium resistance in wheat by over-expressing TaALMT1 .
20804458	0	aluminium	24,33	TaALMT1	123,130	aluminium	TaALMT1	CHEBI:28984	543388(Tax:4565)	Chemical	Gene	resistance|compound|START_ENTITY origins|nmod|resistance include|nsubj|origins include|nmod|END_ENTITY	The multiple origins of aluminium resistance in hexaploid wheat include Aegilops tauschii and more recent cis mutations to TaALMT1 .
1870750	0	aluminium	12,21	erythropoietin	49,63	aluminium	erythropoietin	CHEBI:28984	2056	Chemical	Gene	role|nmod|START_ENTITY role|nmod|resistance resistance|compound|END_ENTITY	The role of aluminium and parathyroid_hormone in erythropoietin resistance in haemodialysis patients .
1775250	0	aluminium	10,19	osteocalcin	23,34	aluminium	osteocalcin	CHEBI:28984	81613(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|production production|compound|END_ENTITY	Effect of aluminium on osteocalcin production in the rat .
6878239	0	aluminium	17,26	parathyroid_hormone	30,49	aluminium	parathyroid hormone	CHEBI:28984	5741	Chemical	Gene	influence|nmod|START_ENTITY influence|nmod|levels levels|amod|END_ENTITY	The influence of aluminium on parathyroid_hormone levels in haemodialysis patients .
8804568	0	aluminium	116,125	prolactin	7,16	aluminium	prolactin	CHEBI:28984	5617	Chemical	Gene	exposed|nmod|START_ENTITY exposed|nsubj|END_ENTITY	Plasma prolactin , cortisol , and thyroid responses of the brown trout -LRB- Salmo trutta -RRB- exposed to lethal and sublethal aluminium in acidic soft waters .
11193083	0	aluminium	32,41	transferrin	66,77	aluminium	transferrin	CHEBI:28984	7018	Chemical	Gene	patterns|nmod|START_ENTITY patterns|nmod|END_ENTITY	Binding patterns of co-existing aluminium and iron to human serum transferrin studied by HPLC-high resolution_ICP-MS .
1747128	1	aluminium	47,56	transferrin	66,77	aluminium	transferrin	CHEBI:28984	7018	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of aluminium by human transferrin in the presence of human albumin and citrate .
1931437	0	aluminium	58,67	transferrin	12,23	aluminium	transferrin	CHEBI:28984	7018	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of transferrin and citrate in cellular uptake of aluminium .
2200784	0	aluminium_phosphide	38,57	renin	7,12	aluminium phosphide	renin	CHEBI:38495	5972	Chemical	Gene	due|xcomp|START_ENTITY END_ENTITY|xcomp|due	Plasma renin activity in shock due to aluminium_phosphide poisoning .
16564191	0	aluminophosphate	32,48	IST-1	49,54	aluminophosphate	IST-1	null	9798	Chemical	Gene	START_ENTITY|dep|using using|nsubj|END_ENTITY	Characterization of microporous aluminophosphate IST-1 using -LRB- 1 -RRB- H Lee-Goldburg techniques .
16928694	1	aluminum	89,97	ALMT1	54,59	aluminum	ALMT1	MESH:D000535	543388(Tax:4565)	Chemical	Gene	resistance|compound|START_ENTITY END_ENTITY|nmod|resistance	ALMT1 gene and its relationship to aluminum resistance .
16055195	0	aluminum	106,114	Acetylcholinesterase	0,20	aluminum	Acetylcholinesterase	MESH:D000535	11423(Tax:10090)	Chemical	Gene	levels|nmod|START_ENTITY peroxidation|nmod|levels peroxidation|nsubj|activation activation|amod|END_ENTITY	Acetylcholinesterase activation and enhanced lipid peroxidation after long-term exposure to low levels of aluminum on different mouse brain regions .
15047894	0	aluminum	106,114	AtGST11	83,90	aluminum	AtGST11	MESH:D000535	839295(Tax:3702)	Chemical	Gene	response|nmod|START_ENTITY END_ENTITY|nmod|response	Mechanism of gene expression of Arabidopsis glutathione_S-transferase , AtGST1 , and AtGST11 in response to aluminum stress .
26265215	0	aluminum	10,18	C-reactive_protein	77,95	aluminum	C-reactive protein	MESH:D000535	1401	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Nanomolar aluminum induces expression of the inflammatory systemic biomarker C-reactive_protein -LRB- CRP -RRB- in human brain microvessel endothelial cells -LRB- hBMECs -RRB- .
1542881	0	aluminum	14,22	CAR	58,61	aluminum	CAR	MESH:D000535	12355(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of aluminum on conditioned avoidance response -LRB- CAR -RRB- in mice .
1331920	0	aluminum	8,16	MAP-2	39,44	aluminum	MAP-2	MESH:D000535	25595(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|END_ENTITY	Dietary aluminum selectively decreases MAP-2 in brains of developing and adult rats .
10487845	0	aluminum	15,23	PHFtau	29,35	aluminum	PHFtau	MESH:D000535	4137	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of aluminum with PHFtau in Alzheimer 's _ disease neurofibrillary_degeneration evidenced by desferrioxamine-assisted chelating autoclave method .
2309580	9	aluminum	1353,1361	PTH	1473,1476	aluminum	PTH	MESH:D000535	24694(Tax:10116)	Chemical	Gene	toxic|nsubj|START_ENTITY toxic|parataxis|capable capable|nsubj|END_ENTITY	These findings indicate -LRB- 1 -RRB- aluminum is toxic to osteoblasts and also directly inhibits mineralization even when osteoblasts are not decreased ; -LRB- 2 -RRB- PTH is capable of increasing osteoblasts even in the presence of aluminum ; and -LRB- 3 -RRB- despite a PTH-induced increase in osteoblast surface , mineralization of osteoid was not improved .
2309580	9	aluminum	1538,1546	PTH	1473,1476	aluminum	PTH	MESH:D000535	24694(Tax:10116)	Chemical	Gene	presence|nmod|START_ENTITY increasing|nmod|presence capable|advcl|increasing capable|nsubj|END_ENTITY	These findings indicate -LRB- 1 -RRB- aluminum is toxic to osteoblasts and also directly inhibits mineralization even when osteoblasts are not decreased ; -LRB- 2 -RRB- PTH is capable of increasing osteoblasts even in the presence of aluminum ; and -LRB- 3 -RRB- despite a PTH-induced increase in osteoblast surface , mineralization of osteoid was not improved .
9626627	0	aluminum	13,21	PTH	43,46	aluminum	PTH	MESH:D000535	24694(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Influence of aluminum on the regulation of PTH - and 1,25 -LRB- OH -RRB- 2D3-dependent pathways in the rat_osteosarcoma cell line ROS 17/2 .8 .
2018119	0	aluminum	53,61	Transferrin	0,11	aluminum	Transferrin	MESH:D000535	24825(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY enhances|dobj|effect enhances|nsubj|END_ENTITY	Transferrin enhances the antiproliferative effect of aluminum on osteoblast-like cells .
10969882	0	aluminum	42,50	Ts65Dn	58,64	aluminum	Ts65Dn	MESH:D000535	21101(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|model model|amod|END_ENTITY	Peptide_YY administration decreases brain aluminum in the Ts65Dn Down_syndrome mouse model .
18470612	0	aluminum	32,40	acetylcholinesterase	48,68	aluminum	acetylcholinesterase	MESH:D000535	83817(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	Effect of long-term exposure to aluminum on the acetylcholinesterase activity in the central nervous system and erythrocytes .
23354609	0	aluminum	37,45	acetylcholinesterase	58,78	aluminum	acetylcholinesterase	MESH:D000535	83817(Tax:10116)	Chemical	Gene	toxicity|compound|START_ENTITY effects|nmod|toxicity effects|nmod|contents contents|amod|END_ENTITY	Protective effects of copper against aluminum toxicity on acetylcholinesterase and catecholamine contents of different regions of rat 's brain .
17112520	0	aluminum	107,115	cathepsin_D	69,80	aluminum	cathepsin D	MESH:D000535	1509	Chemical	Gene	accumulation|compound|START_ENTITY link|nmod|accumulation END_ENTITY|dep|link	Aluminum inhibits proteolytic degradation of amyloid beta peptide by cathepsin_D : a potential link between aluminum accumulation and neuritic_plaque_deposition .
2665187	0	aluminum	79,87	glucose-6-phosphate_dehydrogenase	31,64	aluminum	glucose-6-phosphate dehydrogenase	MESH:D000535	855480(Tax:4932)	Chemical	Gene	inactivation|nmod|START_ENTITY inactivation|nmod|END_ENTITY	Time-dependent inactivation of glucose-6-phosphate_dehydrogenase from yeast by aluminum .
2746239	0	aluminum	87,95	glucose-6-phosphate_dehydrogenase	16,49	aluminum	glucose-6-phosphate dehydrogenase	MESH:D000535	2539	Chemical	Gene	brain|nmod|START_ENTITY Inactivation|nmod|brain Inactivation|nmod|isozymes isozymes|amod|END_ENTITY	Inactivation of glucose-6-phosphate_dehydrogenase isozymes from human and pig brain by aluminum .
14625697	0	aluminum	49,57	glutamate_dehydrogenase	22,45	aluminum	glutamate dehydrogenase	MESH:D000535	2746	Chemical	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of human glutamate_dehydrogenase by aluminum .
18380166	0	aluminum	11,19	insulin-like_growth_factor_I	23,51	aluminum	insulin-like growth factor I	MESH:D000535	24482(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|amod|END_ENTITY	Effects of aluminum on insulin-like_growth_factor_I levels and antioxidant status .
10580122	0	aluminum	53,61	iron_regulatory_protein_2	17,42	aluminum	iron regulatory protein 2	MESH:D000535	3658	Chemical	Gene	Stabilization|nmod|START_ENTITY Stabilization|nmod|END_ENTITY	Stabilization of iron_regulatory_protein_2 , IRP2 , by aluminum .
6308327	0	aluminum	48,56	parathyroid_hormone	15,34	aluminum	parathyroid hormone	MESH:D000535	280903(Tax:9913)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Suppression Suppression|nmod|END_ENTITY	Suppression of parathyroid_hormone secretion by aluminum .
8014635	0	aluminum	15,23	phosvitin	34,43	aluminum	phosvitin	MESH:D000535	1460	Chemical	Gene	Interaction|nmod|START_ENTITY ions|nsubj|Interaction ions|nmod|END_ENTITY	Interaction of aluminum ions with phosvitin .
11325539	0	aluminum	67,75	transferrin	35,46	aluminum	transferrin	MESH:D000535	7018	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of sialic_acid residues of transferrin on the binding with aluminum and iron studied by HPLC/high-resolution ICP-MS .
12739968	0	aluminum	95,103	transferrin	20,31	aluminum	transferrin	MESH:D000535	7018	Chemical	Gene	the|nmod|START_ENTITY ligands|nmod|the ligands|nsubj|Competition Competition|nmod|END_ENTITY	Competition between transferrin and the serum ligands citrate and phosphate for the binding of aluminum .
1375080	0	aluminum	29,37	transferrin	60,71	aluminum	transferrin	MESH:D000535	7018	Chemical	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	Comparative binding study of aluminum and chromium to human transferrin .
2019981	0	aluminum	88,96	transferrin	115,126	aluminum	transferrin	MESH:D000535	7018	Chemical	Gene	mobilization|compound|START_ENTITY mobilization|nmod|END_ENTITY	Evaluation of potential aluminum chelators in vitro by aluminum solubilization ability , aluminum mobilization from transferrin and the octanol/aqueous distribution of the chelators and their complexes with aluminum .
2037846	0	aluminum	27,35	transferrin	64,75	aluminum	transferrin	MESH:D000535	7018	Chemical	Gene	release|nmod|START_ENTITY Kinetics|nmod|release END_ENTITY|nsubj|Kinetics	Kinetics of the release of aluminum from human serum dialuminum transferrin to citrate .
22099154	0	aluminum	41,49	transferrin	70,81	aluminum	transferrin	MESH:D000535	7018	Chemical	Gene	formed|nmod|START_ENTITY formed|nmod|END_ENTITY	A QM/MM study of the complexes formed by aluminum and iron with serum transferrin at neutral and acidic pH. Serum transferrin -LRB- sTf -RRB- transports iron in serum and internalizes in cells via receptor mediated endocytosis .
3586862	0	aluminum	67,75	transferrin	79,90	aluminum	transferrin	MESH:D000535	7018	Chemical	Gene	binding|nmod|START_ENTITY binding|nmod|END_ENTITY	Direct spectrophotometric determination of the two site binding of aluminum to transferrin .
6410138	0	aluminum	7,15	transferrin	28,39	aluminum	transferrin	MESH:D000535	7018	Chemical	Gene	bound|nsubjpass|START_ENTITY bound|nmod|END_ENTITY	Plasma aluminum is bound to transferrin .
8169318	0	aluminum	11,19	transferrin	35,46	aluminum	transferrin	MESH:D000535	7018	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of aluminum to human serum transferrin , human serum albumin and rat serum proteins .
8586971	0	aluminum	42,50	transferrin	67,78	aluminum	transferrin	MESH:D000535	7018	Chemical	Gene	interaction|nmod|START_ENTITY study|nmod|interaction ions|nsubj|study ions|nmod|END_ENTITY	Spectroscopic study of the interaction of aluminum ions with human transferrin .
9208284	0	aluminum	74,82	transferrin	37,48	aluminum	transferrin	MESH:D000535	7018	Chemical	Gene	deposition|compound|START_ENTITY basis|nmod|deposition Competition|dep|basis Competition|nmod|END_ENTITY	Competition of iron and aluminum for transferrin : the molecular basis for aluminum deposition in iron-overloaded dialysis patients ?
10650912	0	aluminum	86,94	tumor_necrosis_factor_alpha	14,41	aluminum	tumor necrosis factor alpha	MESH:D000535	21926(Tax:10090)	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|expression expression|compound|END_ENTITY	Modulation of tumor_necrosis_factor_alpha expression in mouse brain after exposure to aluminum in drinking water .
23059508	0	aluminum_trichloride	34,54	cytochrome_P450	81,96	aluminum trichloride	cytochrome P450	MESH:C010845	25251(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|system system|amod|END_ENTITY	Suppressive effect of accumulated aluminum_trichloride on the hepatic microsomal cytochrome_P450 enzyme system in rats .
24990615	0	alvocidib	97,106	Bcl-xL	74,80	alvocidib	Bcl-xL	MESH:C077990	598	Chemical	Gene	response|amod|START_ENTITY END_ENTITY|nmod|response	Mitochondrial priming of chronic_lymphocytic_leukemia patients associates Bcl-xL dependence with alvocidib response .
25915384	0	amD-3100	69,77	Flap	90,94	amD-3100	Flap	MESH:C088327	241	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Abstract 170 : The Effect Of Bone Marrow Derived Stem Cell Induced By amD-3100 On Expanded Flap .
25915384	0	amD-3100	69,77	Flap	90,94	amD-3100	Flap	MESH:C088327	241	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Abstract 170 : The Effect Of Bone Marrow Derived Stem Cell Induced By amD-3100 On Expanded Flap .
15747698	0	am_251	14,20	CB1	36,39	am 251	CB1	MESH:C103505	25248(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	The effect of am_251 , a cannabinoid CB1 receptor antagonist , on food intake in rats .
272448	0	amalgam	59,66	mucin	8,13	amalgam	mucin	null	100508689	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of mucin and albumin in saline polarization of dental amalgam .
2141919	0	amantadine	10,20	prolactin	24,33	amantadine	prolactin	MESH:D000547	24683(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of amantadine on prolactin secretion , pituitary DNA synthesis and 3H-spiperone binding in male estrogen-treated rats .
6117579	0	amantadine	14,24	prolactin	28,37	amantadine	prolactin	MESH:D000547	5617	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|levels levels|amod|END_ENTITY	The effect of amantadine on prolactin levels and galactorrhea on neuroleptic-treated patients .
15090047	0	amantadine	86,96	sigma_1_receptor	19,35	amantadine	sigma 1 receptor	MESH:D000547	29336(Tax:10116)	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of the sigma_1_receptor in the modulation of dopaminergic transmission by amantadine .
12971972	0	amantadine_sulphate	85,104	IFN-alpha	34,43	amantadine sulphate	IFN-alpha	null	3439	Chemical	Gene	combined|nmod|START_ENTITY combined|nsubj|trial trial|nmod|END_ENTITY	Randomized , controlled trial with IFN-alpha combined with ribavirin with and without amantadine_sulphate in non-responders with chronic hepatitis_C .
3540390	0	amastatin	25,34	enkephalin	90,100	amastatin	enkephalin	MESH:C016977	29237(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|END_ENTITY	The enhancing effects of amastatin , phosphoramidon and captopril on the potency of -LSB- Met5 -RSB- - enkephalin in rat vas deferens .
13679187	0	ambenonium	47,57	AChE	73,77	ambenonium	AChE	CHEBI:2627	43	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	Design , synthesis and biological evaluation of ambenonium derivatives as AChE inhibitors .
19544975	0	ambrisentan	27,38	Endothelin-1	0,12	ambrisentan	Endothelin-1	MESH:C467894	1906	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Endothelin-1 inhibition by ambrisentan as a potential treatment adjunct after debulking surgery in epithelial_ovarian_cancer .
23748747	0	ambrisentan	15,26	SLCO1B1	81,88	ambrisentan	SLCO1B1	MESH:C467894	10599	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of ambrisentan with clarithromycin and its modulation by polymorphic SLCO1B1 .
24103200	0	ambroxol	93,101	thioredoxin	31,42	ambroxol	thioredoxin	MESH:D000551	7295	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nmod|effects	A thioredoxin_reductase and/or thioredoxin system-based mechanism for antioxidant effects of ambroxol .
18394981	0	amelogenin	55,65	A-4	50,53	amelogenin	A-4	null	140494(Tax:10090)	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Identification of the functional activity of the -LSB- A-4 -RSB- amelogenin gene splice product in newborn mouse ameloblasts .
20067920	0	amelogenin	82,92	Amelx	24,29	amelogenin	Amelx	null	265	Chemical	Gene	secretion|nmod|START_ENTITY END_ENTITY|nmod|secretion	A mutation in the mouse Amelx tri-tyrosyl domain results in impaired secretion of amelogenin and phenocopies human X-linked_amelogenesis_imperfecta .
11063034	0	amelogenin	13,23	IGF-I	85,90	amelogenin	IGF-I	null	16000(Tax:10090)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of amelogenin and ameloblastin by insulin and insulin-like growth factors -LRB- IGF-I and IGF-II -RRB- during embryonic mouse tooth development in vitro .
20382373	0	amelogenin	12,22	LAMP-1	45,51	amelogenin	LAMP-1	null	16783(Tax:10090)	Chemical	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Full length amelogenin binds to cell surface LAMP-1 on tooth root/periodontium associated cells .
18676354	0	amelogenin	39,49	LAMP1	15,20	amelogenin	LAMP1	null	3916	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|END_ENTITY	The effects of LAMP1 and LAMP3 on M180 amelogenin uptake , localization and amelogenin mRNA induction by amelogenin protein .
12144868	0	amentoflavone	36,49	COX-2	18,23	amentoflavone	COX-2	MESH:C011164	4513	Chemical	Gene	Downregulation|nmod|START_ENTITY Downregulation|nmod|END_ENTITY	Downregulation of COX-2 and iNOS by amentoflavone and quercetin in A549 human lung_adenocarcinoma cell line .
23970815	0	amentoflavone	91,104	Extracellular_signal-regulated_kinase	0,37	amentoflavone	Extracellular signal-regulated kinase	MESH:C011164	26413(Tax:10090)	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Extracellular_signal-regulated_kinase is a direct target of the anti-inflammatory compound amentoflavone derived from Torreya nucifera .
17268085	0	amentoflavone	55,68	Protein_tyrosine_phosphatase_1B	0,31	amentoflavone	Protein tyrosine phosphatase 1B	MESH:C011164	5770	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Protein_tyrosine_phosphatase_1B inhibitory activity of amentoflavone and its cellular effect on tyrosine phosphorylation of insulin_receptors .
8792657	0	amentoflavone	50,63	phospholipase_C_gamma_1	14,37	amentoflavone	phospholipase C gamma 1	MESH:C011164	5335	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Inhibition of phospholipase_C_gamma_1 activity by amentoflavone isolated from Selaginella tamariscina .
8027933	0	amesergide	50,60	5-HT2-receptor	12,26	amesergide	5-HT2-receptor	MESH:C066736	3356	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Comparative 5-HT2-receptor antagonist activity of amesergide and its active metabolite 4-hydroxyamesergide in rats and rabbits .
20537869	0	amibegron	32,41	beta3_adrenoceptor	4,22	amibegron	beta3 adrenoceptor	MESH:C076252	25645(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	The beta3_adrenoceptor agonist , amibegron -LRB- SR58611A -RRB- counteracts stress-induced behavioral and neurochemical changes .
19167884	0	amide	34,39	CCR5	40,44	amide	CCR5	CHEBI:32988	1234	Chemical	Gene	START_ENTITY|dobj|antagonists antagonists|nummod|END_ENTITY	The design and discovery of novel amide CCR5 antagonists .
24773616	0	amide	38,43	EP2	44,47	amide	EP2	CHEBI:32988	5732	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|compound|END_ENTITY	Lead optimization studies of cinnamic amide EP2 antagonists .
10550416	0	amide	83,88	GLP-1	71,76	amide	GLP-1	CHEBI:32988	24952(Tax:10116)	Chemical	Gene	concentrations|appos|START_ENTITY concentrations|compound|END_ENTITY	Inhibition of dipeptidyl_peptidase_IV with NVP-DPP728 increases plasma GLP-1 -LRB- 7-36 amide -RRB- concentrations and improves oral glucose tolerance in obese Zucker rats .
10877194	2	amide	604,609	GLP-1	459,464	amide	GLP-1	CHEBI:32988	24952(Tax:10116)	Chemical	Gene	potent|nmod|START_ENTITY exendin-4|dep|potent END_ENTITY|amod|exendin-4	Acute central -LRB- intracerebroventricular -LSB- i.c.v. -RSB- -RRB- and peripheral -LRB- subcutaneous -LSB- s.c. -RSB- -RRB- administration of both GLP-1 -LRB- 7-36 -RRB- amide and exendin-4 resulted in a reduction in food intake for at least 4 hours , exendin-4 being much more potent than GLP-1 -LRB- 7-36 -RRB- amide , especially after peripheral administration .
11561219	0	amide	58,63	GLP-1	46,51	amide	GLP-1	CHEBI:32988	2641	Chemical	Gene	mellitus|amod|START_ENTITY mellitus|appos|END_ENTITY	Urinary excretion of glucagon-like_peptide_1 -LRB- GLP-1 -RRB- 7-36 amide in human type 2 -LRB- non-insulin-dependent -RRB- diabetes mellitus .
12967720	0	amide	31,36	GLP-1	38,43	amide	GLP-1	CHEBI:32988	24952(Tax:10116)	Chemical	Gene	terminals|amod|START_ENTITY terminals|appos|END_ENTITY	Glucagon_like_peptide-1 -LRB- 7-36 -RRB- amide -LRB- GLP-1 -RRB- nerve terminals densely innervate corticotropin-releasing_hormone neurons in the hypothalamic paraventricular nucleus .
1313374	0	amide	37,42	GLP-1	25,30	amide	GLP-1	CHEBI:32988	100125288	Chemical	Gene	START_ENTITY|nsubj|Solubilization Solubilization|nmod|END_ENTITY	Solubilization of active GLP-1 -LRB- 7-36 -RRB- amide receptors from RINm5F plasma membranes .
15028945	0	amide	46,51	GLP-1	10,15	amide	GLP-1	CHEBI:32988	2641	Chemical	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of GLP-1 -LRB- glucagon-like_peptide_1 :7 -36 amide -RRB- on porcine pancreatic_endocrine cell proliferation and insulin secretion .
15212985	0	amide	59,64	GLP-1	46,51	amide	GLP-1	CHEBI:32988	14526(Tax:10090)	Chemical	Gene	9-36|dep|START_ENTITY END_ENTITY|dep|9-36	The major glucagon-like_peptide-1 metabolite , GLP-1 - -LRB- 9-36 -RRB- - amide , does not affect glucose or insulin levels in mice .
15655705	2	amide	326,331	GLP-1	268,273	amide	GLP-1	CHEBI:32988	2641	Chemical	Gene	GLP-1|amod|START_ENTITY amidated|dobj|GLP-1 amidated|ccomp|found found|nsubjpass|END_ENTITY	GLP-1 is found in two active forms , amidated GLP-1 -LRB- 7-36 -RRB- amide and glycine-extended GLP-1 -LRB- 7-37 -RRB- , while GIP exists as a single 42 amino_acid peptide .
17065392	0	amide	207,212	GLP-1	174,179	amide	GLP-1	CHEBI:32988	14526(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|exposure exposure|acl|occurring occurring|dobj|metabolites metabolites|nmod|polypeptide polypeptide|appos|END_ENTITY	Effects of sub-chronic exposure to naturally occurring N-terminally truncated metabolites of glucose-dependent insulinotrophic polypeptide -LRB- GIP -RRB- and glucagon-like peptide-1 -LRB- GLP-1 -RRB- , GIP -LRB- 3-42 -RRB- and GLP-1 -LRB- 9-36 -RRB- amide , on insulin secretion and glucose homeostasis in ob/ob mice .
17190759	0	amide	50,55	GLP-1	31,36	amide	GLP-1	CHEBI:32988	100125288	Chemical	Gene	metabolite|appos|START_ENTITY metabolite|nmod|END_ENTITY	The antagonistic metabolite of GLP-1 , GLP-1 -LRB- 9-36 -RRB- amide , does not influence gastric emptying and hunger sensations in man .
17976835	0	amide	64,69	GLP-1	22,27	amide	GLP-1	CHEBI:32988	24952(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|analogues analogues|compound|END_ENTITY	Protective effects of GLP-1 analogues exendin-4 and GLP-1 -LRB- 9-36 -RRB- amide against ischemia-reperfusion injury in rat heart .
18421270	0	amide	13,18	GLP-1	40,45	amide	GLP-1	CHEBI:32988	2641	Chemical	Gene	START_ENTITY|appos|product product|nmod|amide amide|compound|END_ENTITY	GLP-1 _ -LRB- 9-36 -RRB- amide , cleavage product of GLP-1 -LRB- 7-36 -RRB- amide , is a glucoregulatory peptide .
20507928	0	amide	85,90	GLP-1	71,76	amide	GLP-1	CHEBI:32988	2641	Chemical	Gene	effects|dep|START_ENTITY effects|nmod|glucagon-like_peptide-1 glucagon-like_peptide-1|appos|END_ENTITY	Comparative effects of the endogenous agonist glucagon-like_peptide-1 -LRB- GLP-1 -RRB- - -LRB- 7-36 -RRB- amide and the small-molecule ago-allosteric agent `` compound 2 '' at the GLP-1_receptor .
21549160	0	amide	38,43	GLP-1	26,31	amide	GLP-1	CHEBI:32988	14526(Tax:10090)	Chemical	Gene	inhibits|advmod|START_ENTITY inhibits|nsubj|END_ENTITY	GLP-1-derived nonapeptide GLP-1 -LRB- 28-36 -RRB- amide inhibits weight_gain and attenuates diabetes and hepatic_steatosis in diet-induced obese mice .
23035082	0	amide	53,58	GLP-1	41,46	amide	GLP-1	CHEBI:32988	14526(Tax:10090)	Chemical	Gene	rescues|advmod|START_ENTITY rescues|nsubj|END_ENTITY	Glucagon-like_peptide-1 cleavage product GLP-1 -LRB- 9-36 -RRB- amide rescues synaptic plasticity and memory_deficits in Alzheimer 's _ disease model mice .
23094100	0	amide	99,104	GLP-1	70,75	amide	GLP-1	CHEBI:32988	2641	Chemical	Gene	GLP-1|dobj|START_ENTITY GLP-1|nsubj|modulation modulation|nmod|activity activity|nmod|metabolite metabolite|appos|END_ENTITY	Allosteric modulation of the activity of the glucagon-like_peptide-1 -LRB- GLP-1 -RRB- metabolite GLP-1 9-36 amide at the GLP-1_receptor .
23466488	0	amide	47,52	GLP-1	34,39	amide	GLP-1	CHEBI:32988	24952(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY secretion|amod|END_ENTITY	Oral L-glutamine increases active GLP-1 -LRB- 7-36 -RRB- amide secretion and improves glycemic control in stretpozotocin-nicotinamide induced diabetic rats .
24023648	0	amide	122,127	GLP-1	109,114	amide	GLP-1	CHEBI:32988	24952(Tax:10116)	Chemical	Gene	secretion|compound|START_ENTITY secretion|amod|25-diol 25-diol|nmod|sitagliptin sitagliptin|nmod|END_ENTITY	Effect of concomitant administration of L-glutamine and cycloart-23-ene-3b , _ 25-diol -LRB- B2 -RRB- with sitagliptin in GLP-1 -LRB- 7-36 -RRB- amide secretion , biochemical and oxidative stress in streptozotocin - nicotinamide induced diabetic Sprague_Dawley_rats .
24056839	0	amide	112,117	GLP-1	52,57	amide	GLP-1	CHEBI:32988	14526(Tax:10090)	Chemical	Gene	derived|dep|START_ENTITY derived|nmod|metabolism metabolism|nmod|END_ENTITY	In vitro metabolism of the glucagon-like_peptide-1 -LRB- GLP-1 -RRB- - derived metabolites GLP-1 -LRB- 9-36 -RRB- amide and GLP-1 -LRB- 28-36 -RRB- amide in mouse and human hepatocytes .
24056839	0	amide	112,117	GLP-1	79,84	amide	GLP-1	CHEBI:32988	14526(Tax:10090)	Chemical	Gene	derived|dep|START_ENTITY derived|dobj|END_ENTITY	In vitro metabolism of the glucagon-like_peptide-1 -LRB- GLP-1 -RRB- - derived metabolites GLP-1 -LRB- 9-36 -RRB- amide and GLP-1 -LRB- 28-36 -RRB- amide in mouse and human hepatocytes .
24056839	0	amide	90,95	GLP-1	52,57	amide	GLP-1	CHEBI:32988	14526(Tax:10090)	Chemical	Gene	GLP-1|amod|START_ENTITY derived|dobj|GLP-1 derived|nmod|metabolism metabolism|nmod|END_ENTITY	In vitro metabolism of the glucagon-like_peptide-1 -LRB- GLP-1 -RRB- - derived metabolites GLP-1 -LRB- 9-36 -RRB- amide and GLP-1 -LRB- 28-36 -RRB- amide in mouse and human hepatocytes .
24056839	2	amide	485,490	GLP-1	474,479	amide	GLP-1	CHEBI:32988	100125288	Chemical	Gene	metabolites|compound|START_ENTITY metabolites|amod|END_ENTITY	Contrary to the previous notion that GLP-1 -LRB- 7-36 -RRB- amide metabolites are pharmacologically inactive , recent studies have demonstrated cardioprotective and insulinomimetic effects with both GLP-1 -LRB- 9-36 -RRB- amide and GLP-1 -LRB- 28-36 -RRB- amide in animals and humans .
24056839	2	amide	634,639	GLP-1	474,479	amide	GLP-1	CHEBI:32988	100125288	Chemical	Gene	demonstrated|nmod|START_ENTITY demonstrated|ccomp|inactive inactive|nsubj|metabolites metabolites|amod|END_ENTITY	Contrary to the previous notion that GLP-1 -LRB- 7-36 -RRB- amide metabolites are pharmacologically inactive , recent studies have demonstrated cardioprotective and insulinomimetic effects with both GLP-1 -LRB- 9-36 -RRB- amide and GLP-1 -LRB- 28-36 -RRB- amide in animals and humans .
24085036	0	amide	38,43	GLP-1	26,31	amide	GLP-1	CHEBI:32988	14526(Tax:10090)	Chemical	Gene	represses|advmod|START_ENTITY represses|nsubj|END_ENTITY	GLP-1-derived nonapeptide GLP-1 -LRB- 28-36 -RRB- amide represses hepatic gluconeogenic gene expression and improves pyruvate tolerance in high-fat diet-fed mice .
24588343	0	amide	109,114	GLP-1	72,77	amide	GLP-1	CHEBI:32988	403571(Tax:9615)	Chemical	Gene	derived|xcomp|START_ENTITY Pharmacokinetics|acl|derived Pharmacokinetics|appos|END_ENTITY	Pharmacokinetics and metabolism studies on the glucagon-like_peptide-1 -LRB- GLP-1 -RRB- - derived metabolite GLP-1 -LRB- 9-36 -RRB- amide in male Beagle_dogs .
24937653	0	amide	12,17	GLP-1	60,65	amide	GLP-1	CHEBI:32988	403571(Tax:9615)	Chemical	Gene	GLP-1|dep|START_ENTITY GLP-1|appos|product product|nmod|END_ENTITY	GLP-1 -LRB- 32-36 -RRB- amide , a novel pentapeptide cleavage product of GLP-1 , modulates whole body glucose metabolism in dogs .
25144632	0	amide	47,52	GLP-1	35,40	amide	GLP-1	CHEBI:32988	2641	Chemical	Gene	START_ENTITY|amod|peptide_YY3-36 peptide_YY3-36|nmod|END_ENTITY	Combination of peptide_YY3-36 with GLP-1 -LRB- 7-36 -RRB- amide causes an increase in first-phase insulin secretion after IV glucose .
26097706	0	amide	115,120	GLP-1	102,107	amide	GLP-1	CHEBI:32988	14526(Tax:10090)	Chemical	Gene	peptide-1|amod|START_ENTITY peptide-1|dep|END_ENTITY	Ingestion of coffee polyphenols increases postprandial release of the active glucagon-like peptide-1 -LRB- GLP-1 -LRB- 7-36 -RRB- -RRB- amide in C57BL/6J mice .
26178446	1	amide	196,201	GLP-1	290,295	amide	INS-1	CHEBI:32988	16333(Tax:10090)	Chemical	Gene	amide|amod|START_ENTITY amide|acl|derived derived|nmod|hormone hormone|appos|END_ENTITY	UNASSIGNED : We proposed that a pentapeptide , LVKGR amide , GLP-1 -LRB- 32-36 -RRB- amide , derived from the gluco-incretin hormone , glucagon-like_peptide-1 -LRB- GLP-1 -RRB- , might possess favorable actions against diabetes .
26178446	1	amide	217,222	GLP-1	290,295	amide	INS-1	CHEBI:32988	16333(Tax:10090)	Chemical	Gene	START_ENTITY|acl|derived derived|nmod|hormone hormone|appos|END_ENTITY	UNASSIGNED : We proposed that a pentapeptide , LVKGR amide , GLP-1 -LRB- 32-36 -RRB- amide , derived from the gluco-incretin hormone , glucagon-like_peptide-1 -LRB- GLP-1 -RRB- , might possess favorable actions against diabetes .
26186406	8	amide	1228,1233	GLP-1	1084,1089	amide	GLP-2	CHEBI:32988	2641	Chemical	Gene	remained|xcomp|START_ENTITY remained|nsubj|levels levels|nmod|amide amide|compound|END_ENTITY	Twelve lean and 12 obese subjects were enrolled in protocol A and 10 obese volunteers in protocol B. RESULTS : The plasma levels of GLP-1 -LRB- 7-36 -RRB- amide in protocol A and PYY and GLP-2 in protocol B remained unchanged during the exogenous infusion of GLP-1 -LRB- 9-36 -RRB- and GLP-1 -LRB- 7-36 -RRB- amide , respectively .
26341912	0	amide	136,141	GLP-1	123,128	amide	GLP-1	CHEBI:32988	100125288	Chemical	Gene	START_ENTITY|nsubj|New New|acl|screening screening|nmod|identification identification|nmod|modulators modulators|nmod|END_ENTITY	New screening strategy and analysis for identification of allosteric modulators for glucagon-like_peptide-1_receptor using GLP-1 -LRB- 9-36 -RRB- amide .
2849249	0	amide	82,87	GLP-1	89,94	amide	GLP-1	CHEBI:32988	100125288	Chemical	Gene	START_ENTITY|ccomp|amide amide|nsubj|END_ENTITY	-LSB- The entero-insular_axis : the new incretin candidate glucagon-like_peptide-1 -LRB- 7-36 -RRB- amide -LRB- GLP-1 -LRB- 7-36 -RRB- -RRB- amide -RSB- .
3203741	0	amide	45,50	GLP-1	34,39	amide	GLP-1	CHEBI:32988	24952(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Isolation Isolation|nmod|END_ENTITY	Isolation and characterisation of GLP-1 7-36 amide from rat intestine .
7556991	0	amide	22,27	GLP-1	11,16	amide	GLP-1	CHEBI:32988	24952(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Failure Failure|nmod|END_ENTITY	Failure of GLP-1 -LRB- 7-36 -RRB- amide to affect glycogenesis in rat skeletal muscle .
7612912	0	amide	76,81	GLP-1	63,68	amide	GLP-1	CHEBI:32988	2641	Chemical	Gene	-RSB-|amod|START_ENTITY -LSB-|dobj|-RSB- -LSB-|nsubj|actions actions|appos|END_ENTITY	Insulinotropic actions of intravenous glucagon-like_peptide-1 -LRB- GLP-1 -RRB- -LSB- 7-36 amide -RSB- in the fasting state in healthy subjects .
7672496	0	amide	79,84	GLP-1	67,72	amide	GLP-1	CHEBI:32988	2641	Chemical	Gene	-RSB-|amod|START_ENTITY -LSB-|dobj|-RSB- -LSB-|nsubj|properties properties|nmod|END_ENTITY	Pharmacokinetic , insulinotropic , and glucagonostatic properties of GLP-1 -LSB- 7-36 amide -RSB- after subcutaneous injection in healthy volunteers .
7692203	0	amide	71,76	GLP-1	60,65	amide	GLP-1	CHEBI:32988	100125288	Chemical	Gene	START_ENTITY|nsubj|action action|nmod|END_ENTITY	Amylin alters the biological action of the incretin hormone GLP-1 -LRB- 7-36 -RRB- amide .
7867889	0	amide	39,44	GLP-1	28,33	amide	GLP-1	CHEBI:32988	24952(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|END_ENTITY	Potent glycogenic effect of GLP-1 -LRB- 7-36 -RRB- amide in rat skeletal muscle .
7943240	0	amide	45,50	GLP-1	32,37	amide	GLP-1	CHEBI:32988	24952(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|receptors receptors|nmod|END_ENTITY	Rat parietal cell receptors for GLP-1 - -LRB- 7-36 -RRB- amide : northern blot , cross-linking , and radioligand binding .
7956929	0	amide	30,35	GLP-1	163,168	amide	GLP-1	CHEBI:32988	24952(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|metabolism metabolism|dep|one one|nmod|sites sites|nmod|action action|compound|END_ENTITY	Glucagon-like_peptide-1 -LRB- 7-36 -RRB- amide -LRB- GLP-1 -RRB- enhances insulin-stimulated glucose metabolism in 3T3-L1 adipocytes : one of several potential extrapancreatic sites of GLP-1 action .
8550773	0	amide	145,150	GLP-1	131,136	amide	GLP-1	CHEBI:32988	2641	Chemical	Gene	patients|amod|START_ENTITY 7-36|dep|patients emptying|dep|7-36 emptying|dep|effects effects|nmod|exogenous exogenous|appos|END_ENTITY	Gastric emptying , glucose responses , and insulin secretion after a liquid test meal : effects of exogenous glucagon-like_peptide-1 -LRB- GLP-1 -RRB- - -LRB- 7-36 -RRB- amide in type 2 -LRB- noninsulin-dependent -RRB- diabetic patients .
8612565	0	amide	47,52	GLP-1	36,41	amide	GLP-1	CHEBI:32988	24952(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	The third cytoplasmic domain of the GLP-1 -LSB- 7-36 amide -RSB- receptor is required for coupling to the adenylyl cyclase system .
8650968	0	amide	48,53	GLP-1	36,41	amide	GLP-1	CHEBI:32988	100125288	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	Release of glucagon-like_peptide_1 -LRB- GLP-1 -LSB- 7-36 amide -RSB- -RRB- , gastric inhibitory polypeptide -LRB- GIP -RRB- and insulin in response to oral glucose after upper and lower intestinal resections .
8650968	11	amide	1903,1908	GLP-1	1892,1897	amide	GLP-1	CHEBI:32988	100125288	Chemical	Gene	responses|amod|START_ENTITY responses|compound|END_ENTITY	Inactive Crohn 's _ disease and resections of the small intestine as well as proctocolectomy did not change overall GLP-1 -LSB- 7-36 amide -RSB- responses and especially not the early increment after oral glucose .
8897973	0	amide	39,44	GLP-1	26,31	amide	GLP-1	CHEBI:32988	24952(Tax:10116)	Chemical	Gene	inhibits|advmod|START_ENTITY inhibits|nsubj|administration administration|nmod|END_ENTITY	Central administration of GLP-1 - -LRB- 7-36 -RRB- amide inhibits food and water intake in rats .
8960841	0	amide	61,66	GLP-1	49,54	amide	GLP-1	CHEBI:32988	100125288	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	Effects of subcutaneous glucagon-like_peptide_1 -LRB- GLP-1 -LSB- 7-36 amide -RSB- -RRB- in patients with NIDDM .
9143346	0	amide	70,75	GLP-1	59,64	amide	GLP-1	CHEBI:32988	24952(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|antagonist antagonist|nmod|END_ENTITY	Exendin-4 agonist and exendin -LRB- 9-39 -RRB- amide antagonist of the GLP-1 -LRB- 7-36 -RRB- amide effects in liver and muscle .
9203936	0	amide	62,67	GLP-1	50,55	amide	GLP-1	CHEBI:32988	2641	Chemical	Gene	humans|amod|START_ENTITY humans|appos|END_ENTITY	The inhibitory effect of glucagon-like_peptide-1 -LRB- GLP-1 -RRB- 7-36 amide on gastric_acid secretion in humans depends on an intact vagal innervation .
9272633	7	amide	1558,1563	GLP-1	1598,1603	amide	GLP-1	CHEBI:32988	24952(Tax:10116)	Chemical	Gene	contained|dobj|START_ENTITY contained|nmod|amide amide|amod|END_ENTITY	Only one specimen of terminal ileum contained HPLC-identified GLP-1 -LRB- 1-36 -RRB- amide -LRB- 13 % of total GLI -RRB- in addition to GLP-1 -LRB- 7-36 -RRB- amide -LRB- 31 % of total GLI -RRB- .
9329057	0	amide	106,111	GLP-1	93,98	amide	GLP-1	CHEBI:32988	24952(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|intake intake|nmod|diet diet|nmod|rats rats|nmod|injections injections|nmod|END_ENTITY	Decreased intake of a liquid diet in nonfood-deprived rats following intra-PVN injections of GLP-1 -LRB- 7-36 -RRB- amide .
9458894	0	amide	29,34	GLP-1	16,21	amide	GLP-1	CHEBI:32988	24952(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|infusion infusion|nmod|END_ENTITY	PVN infusion of GLP-1 - -LRB- 7-36 -RRB- amide suppresses feeding but does not induce aversion or alter locomotion in rats .
9614307	0	amide	38,43	GLP-1	45,50	amide	GLP-1	CHEBI:32988	100125288	Chemical	Gene	START_ENTITY|xcomp|response response|dep|END_ENTITY	Plasma glucagon-like peptide-1 -LRB- 7-36 -RRB- amide -LRB- GLP-1 -RRB- response to liquid phase , solid phase , and meals of differing lipid composition .
9827848	0	amide	63,68	GLP-1	50,55	amide	GLP-1	CHEBI:32988	100125288	Chemical	Gene	-RSB-|amod|START_ENTITY END_ENTITY|dep|-RSB-	Normalization of fasting glycaemia by intravenous GLP-1 -LRB- -LSB- 7-36 amide -RSB- or -LSB- 7-37 -RSB- -RRB- in type 2 diabetic patients .
24684235	0	amide	95,100	KAT	90,93	amide	KAT	CHEBI:32988	100131187	Chemical	Gene	formation|amod|START_ENTITY formation|appos|END_ENTITY	Rapid ligations with equimolar reactants in water with the potassium_acyltrifluoroborate -LRB- KAT -RRB- amide formation .
14592505	0	amide	56,61	P2X7_receptor	62,75	amide	P2X7 receptor	CHEBI:32988	5027	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|amod|END_ENTITY	Hit-to-Lead studies : the discovery of potent adamantane amide P2X7_receptor antagonists .
12695525	0	amide	134,139	cholecystokinin_2_receptor	57,83	amide	cholecystokinin 2 receptor	CHEBI:32988	887	Chemical	Gene	interaction|nmod|START_ENTITY END_ENTITY|nmod|interaction	Identification of tyrosine 189 and asparagine 358 of the cholecystokinin_2_receptor in direct interaction with the crucial C-terminal amide of cholecystokinin by molecular modeling , site-directed mutagenesis , and structure/affinity studies .
10087239	0	amide	66,71	glucagon-like_peptide-1	36,59	amide	glucagon-like peptide-1	CHEBI:32988	2641	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of carbohydrate-mediated glucagon-like_peptide-1 -LRB- 7-36 -RRB- amide secretion by circulating non-esterified fatty_acids .
11168389	0	amide	86,91	glucagon-like_peptide-1	14,37	amide	glucagon-like peptide-1	CHEBI:32988	24952(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Expression Expression|nmod|receptor receptor|amod|END_ENTITY	Expression of glucagon-like_peptide-1 -LRB- GLP-1 -RRB- _ receptor and the effect of GLP-1 - -LRB- 7-36 -RRB- amide on insulin release by pancreatic islets during rat ontogenic development .
15930172	0	amide	56,61	glucagon-like_peptide-1	26,49	amide	glucagon-like peptide-1	CHEBI:32988	24952(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of endogenous glucagon-like_peptide-1 -LRB- 7-36 -RRB- amide on glycaemia-lowering effect of oligofructose in streptozotocin-treated rats .
17632702	0	amide	63,68	glucagon-like_peptide-1	32,55	amide	glucagon-like peptide-1	CHEBI:32988	2641	Chemical	Gene	START_ENTITY|nsubj|stimulation stimulation|nmod|END_ENTITY	Continuous stimulation of human glucagon-like_peptide-1 -LRB- 7-36 -RRB- amide in a mouse model -LRB- NOD -RRB- delays onset of autoimmune_type_1_diabetes .
20507928	0	amide	85,90	glucagon-like_peptide-1	46,69	amide	glucagon-like peptide-1	CHEBI:32988	2641	Chemical	Gene	effects|dep|START_ENTITY effects|nmod|END_ENTITY	Comparative effects of the endogenous agonist glucagon-like_peptide-1 -LRB- GLP-1 -RRB- - -LRB- 7-36 -RRB- amide and the small-molecule ago-allosteric agent `` compound 2 '' at the GLP-1_receptor .
2668027	0	amide	65,70	glucagon-like_peptide-1	34,57	amide	glucagon-like peptide-1	CHEBI:32988	24952(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|END_ENTITY	Synergistic stimulatory effect of glucagon-like_peptide-1 -LRB- 7-36 -RRB- amide and glucose-dependent_insulin-releasing_polypeptide on the endocrine rat pancreas .
2729860	0	amide	48,53	glucagon-like_peptide-1	18,41	amide	glucagon-like peptide-1	CHEBI:32988	24952(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification of glucagon-like_peptide-1 -LRB- 7-36 -RRB- amide in rat brain .
8112494	0	amide	53,58	glucagon-like_peptide_1	23,46	amide	glucagon-like peptide 1	CHEBI:32988	2641	Chemical	Gene	START_ENTITY|nsubj|Detection Detection|nmod|END_ENTITY	Detection of the human glucagon-like_peptide_1 -LRB- 7-36 -RRB- amide receptor on insulinoma-derived cell membranes .
9041371	0	amide	41,46	glucagon-like_peptide_1	11,34	amide	glucagon-like peptide 1	CHEBI:32988	2641	Chemical	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of glucagon-like_peptide_1 -LRB- 7-36 amide -RRB- on whole-body protein metabolism in healthy man .
18672316	0	amide	6,11	histone_deacetylase	41,60	amide	histone deacetylase	CHEBI:32988	9734	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|inhibitors inhibitors|nmod|END_ENTITY	Novel amide derivatives as inhibitors of histone_deacetylase : design , synthesis and SAR .
23545708	0	amide	49,54	insulin	58,65	amide	insulin	CHEBI:32988	3630	Chemical	Gene	START_ENTITY|nmod|action action|compound|END_ENTITY	Direct effects of exendin - -LRB- 9,39 -RRB- and GLP-1 - -LRB- 9,36 -RRB- amide on insulin action , b-cell function , and glucose metabolism in nondiabetic subjects .
7861244	0	amide	113,118	lipoprotein_lipase	122,140	amide	lipoprotein lipase	CHEBI:32988	24539(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Investigations into the actions of glucose-dependent_insulinotropic_polypeptide and glucagon-like peptide-1 -LRB- 7-36 -RRB- amide on lipoprotein_lipase activity in explants of rat adipose tissue .
19137910	0	amide	4,9	melanin-concentrating_hormone_receptor_1	25,65	amide	melanin-concentrating hormone receptor 1	CHEBI:32988	2847	Chemical	Gene	START_ENTITY|nmod|antagonists antagonists|amod|END_ENTITY	New amide derivatives as melanin-concentrating_hormone_receptor_1 antagonists for the treatment of obesity .
12070757	0	amide	62,67	nociceptin	46,56	amide	nociceptin	CHEBI:32988	25516(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|characterisation characterisation|nmod|END_ENTITY	Pharmacological characterisation of -LSB- -LRB- pX -RRB- Phe4 -RSB- nociceptin -LRB- 1-13 -RRB- amide analogues .
6183431	0	amide	45,50	substance_P	54,65	amide	substance P	CHEBI:32988	6863	Chemical	Gene	studies|nmod|START_ENTITY studies|nmod|END_ENTITY	Structure-activity studies on the C-terminal amide of substance_P .
19556238	0	amide_hydrogen	100,114	phospholipase_A2	69,85	amide hydrogen	phospholipase A2	null	151056	Chemical	Gene	using|dobj|START_ENTITY END_ENTITY|acl|using	Localizing the membrane binding region of Group VIA Ca2 + - independent phospholipase_A2 using peptide amide_hydrogen / deuterium exchange mass spectrometry .
26365710	0	amide_imidazole	48,63	CYP26A1	102,109	amide imidazole	CYP26A1	null	1592	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|inhibitors inhibitors|compound|END_ENTITY	Design , synthesis , and biological evaluation of amide_imidazole derivatives as novel metabolic enzyme CYP26A1 inhibitors .
23562595	0	amides	30,36	cathepsin_L	50,61	amides	cathepsin L	MESH:D000577	1514	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Identification of new peptide amides as selective cathepsin_L inhibitors : the first step towards selective irreversible inhibitors ?
1495010	0	amides_and_esters	54,71	renin	20,25	amides and esters	renin	null	5972	Chemical	Gene	derived|nmod|START_ENTITY derived|nsubj|Inhibitors Inhibitors|nmod|END_ENTITY	Inhibitors of human renin with C-termini derived from amides_and_esters of alpha-mercaptoalkanoic_acids .
8568568	0	amidino-phenylalanine	57,78	thrombin	108,116	amidino-phenylalanine	thrombin	null	2147	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|inhibitors inhibitors|nmod|END_ENTITY	Design , synthesis and biological activity of novel rigid amidino-phenylalanine derivatives as inhibitors of thrombin .
21168329	0	amidinohydrazones	43,60	furin	4,9	amidinohydrazones	furin	null	5045	Chemical	Gene	inhibitors|advcl|START_ENTITY inhibitors|nsubj|END_ENTITY	New furin inhibitors based on weakly basic amidinohydrazones .
4074501	0	amidinophenylpyruvates	55,77	thrombin	31,39	amidinophenylpyruvates	thrombin	null	2147	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Transition-state inhibition of thrombin and trypsin by amidinophenylpyruvates .
3773342	0	amiflamine	15,25	MAO-A	40,45	amiflamine	MAO-A	MESH:C031466	403450(Tax:9615)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	The effects of amiflamine , a reversible MAO-A inhibitor , on the first pass metabolism of tyramine in dog intestine .
6477643	0	amiflamine	48,58	monoamine_oxidase	62,79	amiflamine	monoamine oxidase	MESH:C031466	29253(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|inhibition inhibition|amod|END_ENTITY	Effects of acute and repeated administration of amiflamine on monoamine_oxidase inhibition in the rat .
11370827	0	amifostine	23,33	erythropoietin	87,101	amifostine	erythropoietin	MESH:D004999	2056	Chemical	Gene	administration|amod|START_ENTITY results|nmod|administration results|nmod|END_ENTITY	Preliminary results of amifostine administration in combination with recombinant human erythropoietin in patients with myelodysplastic_syndromes .
17310843	0	amifostine	50,60	erythropoietin	18,32	amifostine	erythropoietin	MESH:D004999	2056	Chemical	Gene	Recombinant|advcl|START_ENTITY Recombinant|dobj|END_ENTITY	Recombinant human erythropoietin in comparison to amifostine against cisplatin-induced peripheral sensorial_neurotoxicity in rats .
11917294	0	amifostine	97,107	nuclear_transcription_factor_kappaB	27,62	amifostine	nuclear transcription factor kappaB	MESH:D004999	4790	Chemical	Gene	thiol|nmod:poss|START_ENTITY activation|nmod|thiol activation|nmod|END_ENTITY	Differential activation of nuclear_transcription_factor_kappaB , gene expression , and proteins by amifostine 's free thiol in human microvascular endothelial and glioma cells .
12007958	0	amifostine	154,164	nuclear_transcription_factor_kappaB	18,53	amifostine	nuclear transcription factor kappaB	MESH:D004999	4790	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of the nuclear_transcription_factor_kappaB -LRB- NFkappaB -RRB- and differential gene expression in U87 glioma cells after exposure to the cytoprotector amifostine .
7068169	0	amikacin	15,23	CSF	1,4	amikacin	CSF	MESH:D000583	1437	Chemical	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	-LSB- CSF levels of amikacin following systemic application in patients with slightly and severely impaired blood cerebrospinal barrier -LRB- author 's transl -RRB- -RSB- .
1722234	0	amikacin	59,67	granulocyte-colony_stimulating_factor	94,131	amikacin	granulocyte-colony stimulating factor	MESH:D000583	1440	Chemical	Gene	Study|nmod|START_ENTITY Study|nmod|END_ENTITY	-LSB- Study of the increasing effect of therapeutic efficacy of amikacin in combination with human granulocyte-colony_stimulating_factor -LRB- G-CSF -RRB- against experimental urinary_tract_infection in diabetic mice -RSB- .
22357920	7	amiloride	1008,1017	ENaC	997,1001	amiloride	ENaC	MESH:D000584	20276(Tax:10090)	Chemical	Gene	channel|nmod|START_ENTITY channel|appos|END_ENTITY	Inhibition of epithelial Na channel -LRB- ENaC -RRB- with amiloride or benzamil abolished the flow response , suggesting involvement of ENaC in flow-regulated ET-1 synthesis .
23764894	13	amiloride	1342,1351	NHE3	1301,1305	amiloride	NHE3	MESH:D000584	105243(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of NHE3 with 100 M 5 - -LRB- N-ethyl-N-isopropyl -RRB- amiloride decreased luminal-to-serosal and increased serosal-to-luminal Ca flux .
2332047	0	amiloride	19,28	acetylcholinesterase	34,54	amiloride	acetylcholinesterase	MESH:D000584	43	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	The interaction of amiloride with acetylcholinesterase and butyrylcholinesterase .
2556151	0	amiloride	89,98	atrial_natriuretic_factor	31,56	amiloride	atrial natriuretic factor	MESH:D000584	24602(Tax:10116)	Chemical	Gene	system|nmod|START_ENTITY Potentiation|nmod|system Potentiation|nmod|effects effects|nmod|END_ENTITY	Potentiation of the effects of atrial_natriuretic_factor on the cardiovascular system by amiloride .
2970886	0	amiloride	15,24	atrial_natriuretic_factor	54,79	amiloride	atrial natriuretic factor	MESH:D000584	24602(Tax:10116)	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of amiloride and hydrochlorothiazide with atrial_natriuretic_factor in the medullary collecting duct .
7612649	0	amiloride	24,33	butyrylcholinesterase	77,98	amiloride	butyrylcholinesterase	MESH:D000584	590	Chemical	Gene	changes|amod|START_ENTITY changes|nmod|END_ENTITY	Substrate dependence of amiloride - and soman-induced conformation changes of butyrylcholinesterase as evidenced by high-pressure perturbation .
6352481	0	amiloride	71,80	renin	53,58	amiloride	renin	MESH:D000584	100358545(Tax:9986)	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Inhibition of furosemide-induced increases in plasma renin activity by amiloride .
15866288	0	amiloride	72,81	urokinase-type_plasminogen_activator	25,61	amiloride	urokinase-type plasminogen activator	MESH:D000584	100008633(Tax:9986)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of inhibition of urokinase-type_plasminogen_activator -LRB- u-PA -RRB- by amiloride in the cornea and tear fluid of eyes irradiated with UVB .
10738907	0	amiloride	77,86	urokinase_plasminogen_activator	42,73	amiloride	urokinase plasminogen activator	MESH:D000584	5328	Chemical	Gene	basis|nmod|START_ENTITY basis|nmod|END_ENTITY	Molecular basis of specific inhibition of urokinase_plasminogen_activator by amiloride .
10824746	0	amiloride	119,128	urokinase_plasminogen_activator	83,114	amiloride	urokinase plasminogen activator	MESH:D000584	5328	Chemical	Gene	Suppression|nmod|START_ENTITY Suppression|nmod|END_ENTITY	Suppression of the invasive capacity of human breast_cancer cells by inhibition of urokinase_plasminogen_activator via amiloride and B428 .
9422083	0	amiloride	21,30	urokinase_plasminogen_activators	38,70	amiloride	urokinase plasminogen activators	MESH:D000584	25619(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Inhibitory effect of amiloride on the urokinase_plasminogen_activators in prostatic_cancer .
20012150	0	amine	83,88	AOC3	65,69	amine	AOC3	CHEBI:32952	11754(Tax:10090)	Chemical	Gene	oxidase|compound|START_ENTITY oxidase|compound|END_ENTITY	Histamine oxidation in mouse adipose_tissue is controlled by the AOC3 gene-encoded amine oxidase .
11808568	0	amine	37,42	CO2	43,46	amine	CO2	CHEBI:32952	717	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- A study on steam generator in solid amine CO2 purification system -RSB- .
200121	0	amine	86,91	CSF	107,110	amine	CSF	CHEBI:32952	1437	Chemical	Gene	metabolites|compound|START_ENTITY metabolites|nmod|END_ENTITY	Alcohol , sleep and cerebrospinal fluid changes in alcoholics : cyclic_AMP and biogenic amine metabolites in CSF .
9564603	0	amine	41,46	Monoamine_oxidase_A	0,19	amine	Monoamine oxidase A	CHEBI:32952	4128	Chemical	Gene	metabolites|compound|START_ENTITY deficiency|dep|metabolites deficiency|compound|END_ENTITY	Monoamine_oxidase_A deficiency : biogenic amine metabolites in random urine samples .
15988470	0	amine	59,64	SLC18A2	83,90	amine	SLC18A2	CHEBI:32952	6571	Chemical	Gene	START_ENTITY|dobj|gene gene|appos|END_ENTITY	Association of DNA polymorphisms in the synaptic vesicular amine transporter gene -LRB- SLC18A2 -RRB- with alcohol and nicotine dependence .
11956949	0	amine	83,88	SSAO	98,102	amine	SSAO	D000588	29473(Tax:10116)	Chemical	Gene	oxidase|compound|START_ENTITY oxidase|appos|END_ENTITY	Inhibition of monoamine_oxidase modulates the behaviour of semicarbazide-sensitive amine oxidase -LRB- SSAO -RRB- .
12135815	0	amine	30,35	SSAO	45,49	amine	SSAO	CHEBI:32952	314	Chemical	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Serum semicarbazide-sensitive amine oxidase -LRB- SSAO -RRB- activity is an independent marker of carotid_atherosclerosis .
12491790	0	amine	55,60	SSAO	115,119	amine	SSAO	CHEBI:32952	314	Chemical	Gene	oxidase|compound|START_ENTITY termed|nsubj|oxidase termed|dobj|-RSB- -RSB-|appos|END_ENTITY	-LSB- Various mammalian tissues contain cell membrane-bound amine oxidase termed semicarbazide-sensitive_amine_oxidase -LRB- SSAO , EC 1.4.3.6 -RRB- -RSB- .
1395519	0	amine	43,48	SSAO	69,73	amine	SSAO	CHEBI:32952	314	Chemical	Gene	activities|compound|START_ENTITY studies|nmod|activities studies|appos|END_ENTITY	Further studies on semicarbazide-sensitive amine oxidase activities -LRB- SSAO -RRB- of white adipose tissue .
1508797	0	amine	53,58	SSAO	77,81	amine	SSAO	D000588	314	Chemical	Gene	activity|amod|START_ENTITY distribution|nmod|activity distribution|appos|END_ENTITY	A common distribution of the semicarbazide-sensitive amine oxidase activity -LRB- SSAO -RRB- in white adipose tissue -LRB- WAT -RRB- .
16570912	0	amine	72,77	SSAO	87,91	amine	SSAO	CHEBI:32952	8639	Chemical	Gene	oxidase|compound|START_ENTITY oxidase|appos|END_ENTITY	Design , synthesis , and biological evaluation of semicarbazide-sensitive amine oxidase -LRB- SSAO -RRB- inhibitors with anti-inflammatory activity .
21844327	0	amine	68,73	SSAO	83,87	amine	SSAO	CHEBI:32952	8639	Chemical	Gene	members|compound|START_ENTITY members|appos|END_ENTITY	Bioluminescent method for assaying multiple semicarbazide-sensitive amine oxidase -LRB- SSAO -RRB- family members in both 96 - and 384-well formats .
23546801	0	amine	97,102	SSAO	39,43	amine	SSAO	D000588	314	Chemical	Gene	oxidases|compound|START_ENTITY pathophysiology|nmod|oxidases study|dobj|pathophysiology tool|acl|study END_ENTITY|dep|tool	Arterial vascular cell line expressing SSAO : a new tool to study the pathophysiology of vascular amine oxidases .
17505468	0	amine	39,44	TAAR6	67,72	amine	TAAR6	CHEBI:32952	319100	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	A region of 35 kb containing the trace amine associate receptor 6 -LRB- TAAR6 -RRB- gene is associated with schizophrenia in the Irish study of high-density schizophrenia families .
12097405	7	amine	1291,1296	VAP-1	1317,1322	amine	VAP-1	CHEBI:32952	8639	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	In addition , inhibition of the amine oxidase activity of VAP-1 reduced both adhesion and transmigration of lymphocytes to a level similar to that seen with VAP-1 Ab .
9011752	0	amine	48,53	VMAT2	67,72	amine	VMAT2	CHEBI:32952	6571	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Dopamine transporter -LRB- Dat -RRB- and synaptic vesicle amine transporter -LRB- VMAT2 -RRB- gene expression in the substantia nigra of control and Parkinson 's _ disease .
9425092	0	amine	76,81	aminopeptidase_N	98,114	amine	aminopeptidase N	CHEBI:32952	397520(Tax:9823)	Chemical	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Characterization of Glu350 as a critical residue involved in the N-terminal amine binding site of aminopeptidase_N -LRB- EC 3.4.11.2 -RRB- : insights into its mechanism of action .
434246	0	amine	19,24	catechol-O-methyl_transferase	75,104	amine	catechol-O-methyl transferase	CHEBI:32952	1312	Chemical	Gene	oxidase|compound|START_ENTITY role|nmod|oxidase END_ENTITY|nsubj|role	The role of plasma amine oxidase , platelet monoamine oxidase , and red cell catechol-O-methyl_transferase in severe behavioral reactions to disulfiram .
1030499	0	amine	9,14	growth_hormone	26,40	amine	growth hormone	CHEBI:32952	81668(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|control control|nmod|secretion secretion|amod|END_ENTITY	Biogenic amine control of growth_hormone secretion in the fetal and neonatal rat .
1223899	0	amine	44,49	growth_hormone	11,25	amine	growth hormone	CHEBI:32952	81668(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	Effects of growth_hormone on brain biogenic amine levels .
12624735	0	amine	52,57	growth_hormone	17,31	amine	growth hormone	CHEBI:32952	2688	Chemical	Gene	metabolism|amod|START_ENTITY treatment|nmod|metabolism treatment|compound|END_ENTITY	Effects of human growth_hormone -LRB- hrGH -RRB- treatment on amine metabolism in rats subjected to extensive small bowel resection .
2832059	0	amine	39,44	interferon-gamma	10,26	amine	interferon-gamma	CHEBI:32952	3458	Chemical	Gene	metabolism|compound|START_ENTITY Effect|nmod|metabolism Effect|nmod|END_ENTITY	Effect of interferon-gamma on biogenic amine metabolism , electroencephalographic recordings , and transient potentials .
20306300	0	amine	55,60	lysyl_oxidase-like_2	10,30	amine	lysyl oxidase-like 2	CHEBI:32952	4017	Chemical	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	The human lysyl_oxidase-like_2 protein functions as an amine oxidase toward collagen and elastin .
18573102	0	amine	107,112	monoamine_oxidase_A	48,67	amine	monoamine oxidase A	CHEBI:32952	4128	Chemical	Gene	stabilization|nmod|START_ENTITY indicates|dobj|stabilization indicates|nsubj|dependence dependence|nmod|effects effects|nmod|END_ENTITY	The pH dependence of kinetic isotope effects in monoamine_oxidase_A indicates stabilization of the neutral amine in the enzyme-substrate complex .
7527564	0	amine	61,66	monoamine_oxidase_A	11,30	amine	monoamine oxidase A	CHEBI:32952	4128	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Effects of monoamine_oxidase_A inhibition on plasma biogenic amine metabolites in depressed patients .
12963712	0	amine	44,49	ryanodine_receptor	71,89	amine	ryanodine receptor	CHEBI:32952	6261	Chemical	Gene	currents|amod|START_ENTITY currents|nmod|END_ENTITY	Methanethiosulfonate_ethylammonium block of amine currents through the ryanodine_receptor reveals single pore architecture .
16081681	0	amine	44,49	semicarbazide-sensitive_amine_oxidase	70,107	amine	semicarbazide-sensitive amine oxidase	CHEBI:32952	8639	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Anti-inflammatory effects of inhibiting the amine oxidase activity of semicarbazide-sensitive_amine_oxidase .
21225644	0	amine	117,122	vascular_adhesion_protein_1	89,116	amine	vascular adhesion protein 1	CHEBI:32952	11754(Tax:10090)	Chemical	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Regulation of mucosal_addressin_cell_adhesion_molecule_1 expression in human and mice by vascular_adhesion_protein_1 amine oxidase activity .
136359	0	amines	19,25	ATPase	38,44	amines	ATPase	MESH:D000588	13417(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activities activities|compound|END_ENTITY	Effect of biogenic amines and GABA on ATPase activities in mouse tissue .
26574090	0	amines	26,32	CO2	37,40	amines	CO2	MESH:D000588	717	Chemical	Gene	START_ENTITY|nmod|capture capture|compound|END_ENTITY	Toward rational design of amines for CO2 capture : Substituent effect on kinetic process for the reaction of monoethanolamine with CO2 .
1380937	0	amines	58,64	Calcitonin	0,10	amines	Calcitonin	MESH:D000588	24241(Tax:10116)	Chemical	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	Calcitonin enhances the effects of nimodipine on biogenic amines of rat brain .
9521698	0	amines	56,62	N-arginine_dibasic_convertase	14,43	amines	N-arginine dibasic convertase	MESH:D000588	25499(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Regulation of N-arginine_dibasic_convertase activity by amines : putative role of a novel acidic domain as an amine binding site .
20013010	0	amines	88,94	S-adenosylmethionine_decarboxylase	11,45	amines	S-adenosylmethionine decarboxylase	MESH:D000588	380052(Tax:8355)	Chemical	Gene	Effects|dep|START_ENTITY Effects|nmod|END_ENTITY	Effects of S-adenosylmethionine_decarboxylase , polyamines , amino_acids , and weak bases -LRB- amines and ammonia -RRB- on development and ribosomal RNA synthesis in Xenopus embryos .
16	0	amines	71,77	aldehyde_reductase	14,32	amines	aldehyde reductase	MESH:D000588	10327	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of aldehyde_reductase by acidic metabolites of the biogenic amines .
933208	0	amines	93,99	alpha-melanocyte_stimulating_hormone	14,50	amines	alpha-melanocyte stimulating hormone	MESH:D000588	24664(Tax:10116)	Chemical	Gene	metabolism|nmod|START_ENTITY effect|nmod|metabolism effect|nmod|END_ENTITY	The effect of alpha-melanocyte_stimulating_hormone -LRB- alpha-msh -RRB- on the metabolism of biogenic amines in the rat brain .
18038140	0	amines	69,75	arylalkylamine_N-acetyltransferase	8,42	amines	arylalkylamine N-acetyltransferase	MESH:D000588	37867(Tax:7227)	Chemical	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Role of arylalkylamine_N-acetyltransferase in regulation of biogenic amines levels by gonadotropins in Drosophila .
2942391	0	amines	41,47	beta-endorphin	14,28	amines	beta-endorphin	MESH:D000588	5443	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of beta-endorphin on biogenic amines , insulin , and glucagon levels in the hepatic portal circulation of normal and pancreatectomized dogs .
7137351	0	amines	22,28	gastrin	45,52	amines	gastrin	MESH:D000588	25320(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	Importance of dietary amines in meal-induced gastrin release .
2962855	0	amines	136,142	gonadotropin-releasing_hormone	69,99	amines	gonadotropin-releasing hormone	MESH:D000588	25194(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|END_ENTITY	In vitro LH release from the hypothalamus-pars tuberalis ; effects of gonadotropin-releasing_hormone -LRB- GnRH -RRB- , beta-endorphin and biogenic amines .
2862637	0	amines	81,87	growth_hormone	36,50	amines	growth hormone	MESH:D000588	403795(Tax:9615)	Chemical	Gene	surges|nmod|START_ENTITY surges|nsubj|effect effect|nmod|END_ENTITY	Somatostatin mediates the effect of growth_hormone surges on splanchnic biogenic amines .
2875023	0	amines	92,98	growth_hormone	37,51	amines	growth hormone	MESH:D000588	403795(Tax:9615)	Chemical	Gene	dependence|nmod|START_ENTITY dependence|nmod|actions actions|nmod|END_ENTITY	Insulin dependence of the actions of growth_hormone and somatostatin on splanchnic biogenic amines of the dog .
4041988	0	amines	41,47	growth_hormone	14,28	amines	growth hormone	MESH:D000588	403795(Tax:9615)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of growth_hormone on biogenic amines in the hepatic portal circulation of the dog .
6374490	0	amines	88,94	growth_hormone	51,65	amines	growth hormone	MESH:D000588	81668(Tax:10116)	Chemical	Gene	ingestion|nmod|START_ENTITY ingestion|nmod|control control|nmod|secretion secretion|amod|END_ENTITY	Effect of maternal ethanol ingestion on control of growth_hormone secretion by biogenic amines in rat offspring .
1884630	0	amines	34,40	insulin	13,20	amines	insulin	MESH:D000588	3630	Chemical	Gene	START_ENTITY|nsubj|Influence Influence|nmod|END_ENTITY	Influence of insulin and biogenic amines on the division of Chang liver cells after primary exposure -LRB- imprinting -RRB- and repeated treatments .
3343312	0	amines	11,17	lysozyme	75,83	amines	lysozyme	MESH:D000588	4069	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of amines and polyamines on turbidimetric and lysoplate assays for lysozyme .
508206	0	amines	51,57	prolactin	141,150	amines	prolactin	MESH:D000588	24683(Tax:10116)	Chemical	Gene	assay|nmod|START_ENTITY procedure|nmod|assay procedure|dep|application application|nmod|elucidation elucidation|nmod|mechanism mechanism|nmod|release release|compound|END_ENTITY	A simple procedure for the assay of brain biogenic amines by selected-ion monitoring : its application to the elucidation of the mechanism of prolactin release induced by 3-iodo-L-tyrosine .
803259	0	amines	20,26	prolactin	49,58	amines	prolactin	MESH:D000588	24683(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|release release|nmod|END_ENTITY	Effects of biogenic amines and TRH on release of prolactin and TSH in the rat .
25552	0	amines	12,18	renin	20,25	amines	renin	MESH:D000588	5972	Chemical	Gene	START_ENTITY|appos|pressure pressure|compound|END_ENTITY	Sympathetic amines , renin and blood pressure .
3302931	0	amines	11,17	renin	49,54	amines	renin	MESH:D000588	24715(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|release release|compound|END_ENTITY	Effects of amines , monensin and nigericin on the renin release from isolated superfused rat glomeruli .
22647861	0	amino	11,16	ANKH	6,10	amino	ANKH	CHEBI:46882	56172	Chemical	Gene	mutation|amod|START_ENTITY mutation|compound|END_ENTITY	Novel ANKH amino terminus mutation -LRB- Pro5Ser -RRB- associated with early-onset calcium_pyrophosphate_disease with associated phosphaturia .
11463327	2	amino	231,236	C-4	246,249	amino	C-5	CHEBI:46882	727	Chemical	Gene	group|amod|START_ENTITY group|nmod|END_ENTITY	The key reactions are an internal displacement by nitrogen to introduce the cis amino group at C-4 and the methylation of an enolate at C-5 .
14715087	0	amino	36,41	Fv1	93,96	amino	Fv1	CHEBI:46882	14349(Tax:10090)	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Consensus structural models for the amino terminal domain of the retrovirus restriction gene Fv1 and the murine_leukaemia_virus capsid proteins .
10461915	1	amino	273,278	GRK1	412,416	amino	GRK1	CHEBI:46882	6011	Chemical	Gene	mutants|amod|START_ENTITY mutants|nmod|END_ENTITY	To investigate functions of the consensus amino terminus of G protein-coupled receptor kinases -LRB- GRKs -RRB- , two amino terminus-truncated mutants -LRB- delta30 or delta15 -RRB- and two single-amino-acid mutants of conserved acidic residues -LRB- D2A or E7A -RRB- of human GRK1 were constructed and expressed in human embryonic kidney 293 cells .
23604598	0	amino	36,41	GluN2A	75,81	amino	GluN2A	CHEBI:46882	2903	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Cysteine residues 87 and 320 in the amino terminal domain of NMDA receptor GluN2A govern its homodimerization but do not influence GluN2A/GluN1 heteromeric assembly .
7563086	0	amino	4,9	Rev	35,38	amino	Rev	CHEBI:46882	155908(Tax:11676)	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	The amino terminal domain of HIV-1 Rev is required for discrimination of the RRE from nonspecific RNA .
17499612	0	amino	67,72	T1R3	62,66	amino	T1R3	CHEBI:46882	83756	Chemical	Gene	domain|amod|START_ENTITY domain|compound|END_ENTITY	Taste-modifying sweet protein , neoculin , is received at human T1R3 amino terminal domain .
22172556	0	amino	45,50	androgen_receptor	93,110	amino	androgen receptor	CHEBI:46882	367	Chemical	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	Anti-androgen effects of cypermethrin on the amino - and carboxyl-terminal interaction of the androgen_receptor .
9469594	0	amino	122,127	apoA-I	147,153	amino	apoA-I	CHEBI:46882	335	Chemical	Gene	region|amod|START_ENTITY region|nmod|END_ENTITY	Binding of phospholipid_transfer_protein -LRB- PLTP -RRB- to apolipoproteins_A-I_and_A-II : location of a PLTP binding domain in the amino terminal region of apoA-I .
11522008	0	amino	82,87	beta2-glycoprotein_I	107,127	amino	beta2-glycoprotein I	CHEBI:46882	350	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Beta2-glycoprotein_I-dependent anticardiolipin antibodies preferentially bind the amino terminal domain of beta2-glycoprotein_I .
8910316	0	amino	15,20	bradykinin	36,46	amino	bradykinin	CHEBI:46882	3827	Chemical	Gene	group|amod|START_ENTITY group|nmod|END_ENTITY	The N-terminal amino group of -LSB- Tyr8 -RSB- bradykinin is bound adjacent to analogous amino_acids of the human and rat B2_receptor .
9079650	0	amino	111,116	c-Jun	105,110	amino	c-Jun	CHEBI:46882	16476(Tax:10090)	Chemical	Gene	kinase|amod|START_ENTITY kinase|amod|END_ENTITY	Cloning of a novel mitogen-activated protein kinase kinase kinase , MEKK4 , that selectively regulates the c-Jun amino terminal kinase pathway .
6636042	0	amino	56,61	fibrinogen	81,91	amino	fibrinogen	CHEBI:46882	2244	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Comparative study of the iodination of tyrosines in the amino terminal domain of fibrinogen and in N-DSK and fibrin-N-DSK .
94836	0	amino	23,28	fibrinogen	81,91	amino	fibrinogen	CHEBI:46882	2244	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|chain chain|nmod|END_ENTITY	Internalization of the amino terminal 1-78 sequence of the gamma chain of native fibrinogen and exposure associated with catabolism and plasmin cleavage .
7329823	0	amino	7,12	gastrin	46,53	amino	gastrin	CHEBI:46882	25320(Tax:10116)	Chemical	Gene	structure|amod|START_ENTITY structure|nmod|END_ENTITY	Unique amino terminal structure of rat little gastrin .
18827003	0	amino	30,35	glucocorticoid_receptor	65,88	amino	glucocorticoid receptor	CHEBI:46882	2908	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	A novel point mutation in the amino terminal domain of the human glucocorticoid_receptor -LRB- hGR -RRB- gene enhancing hGR-mediated gene expression .
7499275	0	amino	9,14	myosin_heavy_chain	110,128	amino	myosin heavy chain	CHEBI:46882	3133	Chemical	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	Both the amino and carboxyl termini of Dictyostelium myosin essential light chain are required for binding to myosin_heavy_chain .
11606716	0	amino	18,23	p53	57,60	amino	p53	CHEBI:46882	7157	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Peptides from the amino terminal mdm-2-binding domain of p53 , designed from conformational analysis , are selectively cytotoxic to transformed cells .
3566757	0	amino	4,9	p56_lck	33,40	amino	p56 lck	CHEBI:46882	16818(Tax:10090)	Chemical	Gene	region|amod|START_ENTITY region|nmod|END_ENTITY	The amino terminal region of the p56_lck from LSTRA exerts negative modulation on the tyrosine kinase activity .
10713702	0	amino	20,25	p57Kip2	45,52	amino	p57Kip2	CHEBI:46882	1028	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Dimerization of the amino terminal domain of p57Kip2 inhibits cyclin_D1-cdk4 kinase activity .
2904385	0	amino	78,83	parathyroid_hormone	103,122	amino	parathyroid hormone	CHEBI:46882	280903(Tax:9913)	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	The beta-subunit of the bovine mitochondrial F1 ATPase specifically binds the amino terminal domain of parathyroid_hormone .
3085590	0	amino	29,34	phosphoenolpyruvate_carboxylase	44,75	amino	phosphoenolpyruvate carboxylase	CHEBI:46882	100101511(Tax:4577)	Chemical	Gene	group|amod|START_ENTITY group|nmod|END_ENTITY	Modification of an essential amino group of phosphoenolpyruvate_carboxylase from maize leaves by pyridoxal_phosphate and by pyridoxal_phosphate-sensitized photooxidation .
24878028	0	amino	50,55	prion_protein	78,91	amino	prion protein	CHEBI:46882	19122(Tax:10090)	Chemical	Gene	group|amod|START_ENTITY group|nmod|END_ENTITY	Copper -LRB- II -RRB- sequentially loads onto the N-terminal amino group of the cellular prion_protein before the individual octarepeats .
12193299	0	amino	49,54	thyrotropin_receptor	74,94	amino	thyrotropin receptor	CHEBI:46882	7253	Chemical	Gene	region|amod|START_ENTITY region|nmod|END_ENTITY	Cross-reactivity of a monoclonal antibody to the amino terminal region of thyrotropin_receptor with the serum protein alpha -LRB- 1 -RRB- - antitrypsin .
2566328	0	amino	17,22	transglutaminase	76,92	amino	transglutaminase	CHEBI:46882	100379228(Tax:10141)	Chemical	Gene	Determination|nmod|START_ENTITY Determination|nmod|END_ENTITY	Determination of amino - and carboxyl-terminal sequences of guinea_pig liver transglutaminase : evidence for amino-terminal processing .
1731193	0	amino	12,17	tumor_necrosis_factor	49,70	amino	tumor necrosis factor	CHEBI:46882	7124	Chemical	Gene	functions|amod|START_ENTITY role|nmod|functions role|nmod|END_ENTITY	The role of amino functions in recombinant human tumor_necrosis_factor in expression of biological activity .
7864898	0	amino	100,105	tumor_necrosis_factor	42,63	amino	tumor necrosis factor	CHEBI:46882	7124	Chemical	Gene	terminus|amod|START_ENTITY having|dobj|terminus END_ENTITY|acl|having	Creation of a high cytotoxic active human tumor_necrosis_factor having the truncated and more basic amino terminus .
7872693	0	amino	11,16	tumor_necrosis_factor	40,61	amino	tumor necrosis factor	CHEBI:46882	7124	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|production production|compound|END_ENTITY	Effects of amino and imino_acridines on tumor_necrosis_factor production by human leukocytes .
9065387	0	amino-acid	72,82	BAP2	129,133	amino-acid	BAP2	CHEBI:33704	852360(Tax:4932)	Chemical	Gene	uptake|amod|START_ENTITY uptake|nmod|END_ENTITY	STP1 , a gene involved in pre-tRNA processing in yeast , is important for amino-acid uptake and transcription of the permease gene BAP2 .
7042342	0	amino-acid	34,44	DNA-binding_protein	74,93	amino-acid	DNA-binding protein	CHEBI:33704	18157783	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Biological activity and a partial amino-acid sequence of Escherichia_coli DNA-binding_protein I isolated from overproducing cells .
16431218	0	amino-acid	9,19	ERK1/2	30,36	amino-acid	ERK1/2	CHEBI:33704	5595;5594	Chemical	Gene	change|amod|START_ENTITY change|nmod|END_ENTITY	A single amino-acid change in ERK1/2 makes the enzyme susceptible to PP1 derivatives .
9546655	0	amino-acid	32,42	Galectin-1	0,10	amino-acid	Galectin-1	CHEBI:33704	3956	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|dep|sequence	Galectin-1 from ovine placenta -- amino-acid sequence , physicochemical properties and implications in T-cell death .
7032915	0	amino-acid	47,57	Glutathione_reductase	0,21	amino-acid	Glutathione reductase	CHEBI:33704	2936	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|dep|sequence	Glutathione_reductase from human erythrocytes : amino-acid sequence of the structurally known FAD-binding domain .
710402	0	amino-acid	13,23	H2B	44,47	amino-acid	H2B	CHEBI:33704	8349	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The complete amino-acid sequence of histone H2B -LRB- 3 -RRB- from sperm of the sea urchin Parechinus angulosus .
15965644	0	amino-acid	10,20	HFE	31,34	amino-acid	HFE	CHEBI:33704	3077	Chemical	Gene	change|amod|START_ENTITY change|nmod|END_ENTITY	The Q283P amino-acid change in HFE leads to structural and functional consequences similar to those described for the mutated 282Y HFE protein .
7959024	0	amino-acid	21,31	HoxB3	6,11	amino-acid	HoxB3	CHEBI:33704	395502(Tax:9031)	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|dep|sequence	Chick HoxB3 : deduced amino-acid sequence and embryonic gene expression .
21371427	0	amino-acid	23,33	LAT1	115,119	amino-acid	LAT1	CHEBI:33704	20539(Tax:10090)	Chemical	Gene	transporter|amod|START_ENTITY Oncogenicity|nmod|transporter revealed|nsubj|Oncogenicity revealed|parataxis|target target|nsubj|END_ENTITY	Oncogenicity of L-type amino-acid transporter 1 -LRB- LAT1 -RRB- revealed by targeted gene disruption in chicken DT40 cells : LAT1 is a promising molecular target for human cancer therapy .
21371427	0	amino-acid	23,33	LAT1	49,53	amino-acid	LAT1	CHEBI:33704	20539(Tax:10090)	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Oncogenicity of L-type amino-acid transporter 1 -LRB- LAT1 -RRB- revealed by targeted gene disruption in chicken DT40 cells : LAT1 is a promising molecular target for human cancer therapy .
24762957	0	amino-acid	27,37	LAT1	62,66	amino-acid	LAT1	D000596	8140	Chemical	Gene	expression|amod|START_ENTITY significance|nmod|expression significance|dep|END_ENTITY	Prognostic significance of amino-acid transporter expression -LRB- LAT1 , ASCT2 , and xCT -RRB- in surgically resected tongue_cancer .
9630560	0	amino-acid	17,27	STAT3	52,57	amino-acid	STAT3	CHEBI:33704	20848(Tax:10090)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Highly conserved amino-acid sequence between murine STAT3 and a revised human STAT3 sequence .
3593735	0	amino-acid	92,102	St1	135,138	amino-acid	St1	CHEBI:33704	6386	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Isolation and characterization of two protamines St1 and St2 from stallion spermatozoa , and amino-acid sequence of the major protamine St1 .
17881823	5	amino-acid	628,638	TYW1	665,669	amino-acid	TYW1	CHEBI:33704	855894(Tax:4932)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The amino-acid sequence of P. _ horikoshii TYW1 suggested that it is a radical-AdoMet enzyme and the tertiary structure of P. _ horikoshii TYW1 indeed shares the modified TIM-barrel structure found in other radical-AdoMet enzymes .
10869252	0	amino-acid	43,53	alcohol_dehydrogenase_alpha-chain	72,105	amino-acid	alcohol dehydrogenase alpha-chain	CHEBI:33704	124	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Frequency and Markov chain analysis of the amino-acid sequence of human alcohol_dehydrogenase_alpha-chain .
4040766	0	amino-acid	4,14	beta-lactoglobulin_II	27,48	amino-acid	beta-lactoglobulin II	CHEBI:33704	100034194(Tax:9796)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The amino-acid sequence of beta-lactoglobulin_II from horse colostrum -LRB- Equus_caballus , Perissodactyla -RRB- : beta-lactoglobulins are retinol-binding proteins .
14571276	0	amino-acid	174,184	calsequestrin_2	158,173	amino-acid	calsequestrin 2	CHEBI:33704	845	Chemical	Gene	polymorphisms|amod|START_ENTITY polymorphisms|amod|END_ENTITY	Molecular genetics of exercise-induced polymorphic ventricular_tachycardia : identification of three novel cardiac ryanodine receptor mutations and two common calsequestrin_2 amino-acid polymorphisms .
1675855	0	amino-acid	11,21	dipeptidyl_peptidase_IV	45,68	amino-acid	dipeptidyl peptidase IV	CHEBI:33704	397492(Tax:9823)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	N-terminal amino-acid sequence of pig kidney dipeptidyl_peptidase_IV solubilized by autolysis .
10889558	0	amino-acid	71,81	dopamine_beta-hydroxylase	100,125	amino-acid	dopamine beta-hydroxylase	CHEBI:33704	1621	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The first , second , third and fourth order Markov chain analysis on the amino-acid sequence of human dopamine_beta-hydroxylase .
4202846	0	amino-acid	7,17	flagellin	30,39	amino-acid	flagellin	CHEBI:33704	936664(Tax:224308)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	On the amino-acid sequence of flagellin from Bacillus_subtilis_168 : comparison with other bacterial flagellins .
2647150	0	amino-acid	37,47	insulin	60,67	amino-acid	insulin	CHEBI:33704	3630	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Purification of a marsupial insulin : amino-acid sequence of insulin from the eastern grey kangaroo Macropus giganteus .
26434594	0	amino-acid	20,30	mTORC1	66,72	amino-acid	mTORC1	D000596	382056(Tax:10090)	Chemical	Gene	sensitivity|amod|START_ENTITY sensitivity|nmod|END_ENTITY	PAT4 levels control amino-acid sensitivity of rapamycin-resistant mTORC1 from the Golgi and affect clinical outcome in colorectal_cancer .
4509319	0	amino-acid	27,37	parathyroid_hormone	6,25	amino-acid	parathyroid hormone	CHEBI:33704	5741	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|dep|sequence	Human parathyroid_hormone : amino-acid sequence of the amino-terminal residues 1-34 .
1080707	0	amino-acid	4,14	parvalbumin	49,60	amino-acid	parvalbumin	CHEBI:33704	100343964(Tax:9986)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The amino-acid sequence of the most acidic major parvalbumin from frog muscle .
862613	0	amino-acid	4,14	parvalbumin	37,48	amino-acid	parvalbumin	CHEBI:33704	5816	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The amino-acid sequence of the major parvalbumin from thornback-ray muscle .
3045563	0	amino-acid	19,29	thrombospondin	42,56	amino-acid	thrombospondin	CHEBI:33704	7057	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	A highly conserved amino-acid sequence in thrombospondin , properdin and in proteins from sporozoites and blood stages of a human malaria parasite .
3365331	0	amino-acid	43,53	transferrin	73,84	amino-acid	transferrin	CHEBI:33704	100009267(Tax:9986)	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Isolation , characterization and N-terminal amino-acid sequence of rabbit transferrin .
8740442	0	amino-acids	76,87	cysteine_sulfinate_decarboxylase	15,47	amino-acids	cysteine sulfinate decarboxylase	CHEBI:33709	51380	Chemical	Gene	Specificity|nmod|START_ENTITY Specificity|nmod|END_ENTITY	Specificity of cysteine_sulfinate_decarboxylase -LRB- CSD -RRB- for sulfur-containing amino-acids .
6818083	0	amino-acids	10,21	insulin	38,45	amino-acids	insulin	CHEBI:33709	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of amino-acids on secretion of insulin by isolated islets of the monkey .
23352510	0	amino-pyrimidine	15,31	c-Jun_N-terminal_kinase	46,69	amino-pyrimidine	c-Jun N-terminal kinase	CHEBI:38338	116554(Tax:10116)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Development of amino-pyrimidine inhibitors of c-Jun_N-terminal_kinase -LRB- JNK -RRB- : kinase profiling guided optimization of a 1,2,3-benzotriazole lead .
2779585	0	amino_acid	39,49	3_beta-hydroxy-5-ene_steroid_dehydrogenase	68,110	amino acid	3 beta-hydroxy-5-ene steroid dehydrogenase	CHEBI:33704	3283	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Full length cDNA structure and deduced amino_acid sequence of human 3_beta-hydroxy-5-ene_steroid_dehydrogenase .
10799513	0	amino_acid	80,90	4F2_heavy_chain	30,45	amino acid	4F2 heavy chain	CHEBI:33704	6520	Chemical	Gene	START_ENTITY|nsubj|influence influence|nmod|END_ENTITY	Differential influence of the 4F2_heavy_chain and the protein related to b -LRB- 0 , + -RRB- amino_acid transport on substrate affinity of the heteromeric b -LRB- 0 , + -RRB- amino_acid transporter .
7755630	0	amino_acid	24,34	5-HT1A_receptor	62,77	amino acid	5-HT1A receptor	CHEBI:33704	3350	Chemical	Gene	substitutions|amod|START_ENTITY substitutions|nmod|END_ENTITY	Two naturally occurring amino_acid substitutions in the human 5-HT1A_receptor : glycine_22_to_serine 22 and isoleucine_28_to_valine 28 .
8959291	0	amino_acid	24,34	5-HT2A_receptor	56,71	amino acid	5-HT2A receptor	CHEBI:33704	3356	Chemical	Gene	substitutions|amod|START_ENTITY substitutions|nmod|END_ENTITY	Two naturally occurring amino_acid substitutions of the 5-HT2A_receptor : similar prevalence in patients with seasonal_affective_disorder and controls .
1975105	0	amino_acid	34,44	AA2	19,22	amino acid	AA2	CHEBI:33704	100034703	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	A possible role of AA2 excitatory amino_acid receptors in the expression of stimulant drug effects .
22916205	0	amino_acid	56,66	AAT-6	122,127	amino acid	AAT-6	CHEBI:33704	188421(Tax:6239)	Chemical	Gene	transporter|amod|START_ENTITY transporter|nmod|maintenance maintenance|nmod|END_ENTITY	NRFL-1 , the C. _ elegans NHERF orthologue , interacts with amino_acid transporter 6 -LRB- AAT-6 -RRB- for age-dependent maintenance of AAT-6 on the membrane .
22916205	0	amino_acid	56,66	AAT-6	82,87	amino acid	AAT-6	CHEBI:33704	188421(Tax:6239)	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	NRFL-1 , the C. _ elegans NHERF orthologue , interacts with amino_acid transporter 6 -LRB- AAT-6 -RRB- for age-dependent maintenance of AAT-6 on the membrane .
20569305	0	amino_acid	48,58	AAT1p	72,77	amino acid	AAT1p	CHEBI:33704	853755(Tax:4932)	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Characterization of a developmentally regulated amino_acid transporter -LRB- AAT1p -RRB- of the rust fungus Uromyces fabae .
3333842	1	amino_acid	64,74	ADH-1	111,116	amino acid	ADH-1	CHEBI:33704	854068(Tax:4932)	Chemical	Gene	START_ENTITY|nmod|site site|nmod|END_ENTITY	Effects of two amino_acid changes in the active site of yeast ADH-1 .
11299361	0	amino_acid	30,40	ANT1	0,4	amino acid	ANT1	CHEBI:33704	820363(Tax:3702)	Chemical	Gene	transporter|amod|START_ENTITY END_ENTITY|appos|transporter	ANT1 , an aromatic and neutral amino_acid transporter in Arabidopsis .
10966787	0	amino_acid	18,28	AP-2	62,66	amino acid	AP-2	CHEBI:33704	21418(Tax:10090)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Identification of amino_acid residues of transcription factor AP-2 involved in DNA binding .
3148444	0	amino_acid	31,41	AP50	54,58	amino acid	AP50	CHEBI:33704	116563(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Molecular cloning and complete amino_acid sequence of AP50 , an assembly protein associated with clathrin-coated vesicles .
10082979	2	amino_acid	203,213	AR	240,242	amino acid	AR	CHEBI:33704	367	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The amino_acid sequence of red sea bream AR -LRB- rsAR -RRB- shows about 45 % identity with that of Xenopus , rat , mouse , and human AR .
11122465	0	amino_acid	70,80	ARF1	104,108	amino acid	ARF1	CHEBI:33704	40506(Tax:7227)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	A locust type 1 ADP-ribosylation_factor -LRB- lARF1 -RRB- * is 100 % identical in amino_acid sequence to Drosophila ARF1 despite obvious DNA sequence divergence .
16897601	0	amino_acid	73,83	ASCT-1	99,105	amino acid	ASCT-1	D000596	6509	Chemical	Gene	START_ENTITY|dobj|1 1|appos|END_ENTITY	Changes in region - and cell type-specific expression patterns of neutral amino_acid transporter 1 -LRB- ASCT-1 -RRB- in the anterior cingulate cortex and hippocampus in schizophrenia , bipolar_disorder and major_depression .
8910405	0	amino_acid	20,30	ASCT-1	0,6	amino acid	ASCT-1	CHEBI:33704	6509	Chemical	Gene	exchanger|amod|START_ENTITY exchanger|nsubj|END_ENTITY	ASCT-1 is a neutral amino_acid exchanger with chloride channel activity .
12533615	0	amino_acid	8,18	ASCT1	31,36	amino acid	ASCT1	CHEBI:33704	55963(Tax:10090)	Chemical	Gene	START_ENTITY|ccomp|expressed expressed|nsubjpass|END_ENTITY	Neutral amino_acid transporter ASCT1 is preferentially expressed in L-Ser-synthetic/storing glial cells in the mouse brain with transient expression in developing capillaries .
10698697	0	amino_acid	8,18	ASCT2	31,36	amino acid	ASCT2	CHEBI:33704	444522(Tax:8355)	Chemical	Gene	START_ENTITY|ccomp|displays displays|nsubj|END_ENTITY	Neutral amino_acid transporter ASCT2 displays substrate-induced Na + exchange and a substrate-gated anion conductance .
11350958	0	amino_acid	57,67	ASCT2	43,48	amino acid	ASCT2	CHEBI:33704	6510	Chemical	Gene	START_ENTITY|nsubj|forms forms|nmod|function function|amod|neutral neutral|dep|END_ENTITY	Truncated forms of the dual function human ASCT2 neutral amino_acid transporter/retroviral receptor are translationally initiated at multiple alternative CUG and GUG codons .
12175968	0	amino_acid	65,75	ASCT2	99,104	amino acid	ASCT2	CHEBI:33704	6510	Chemical	Gene	START_ENTITY|dobj|B B|appos|END_ENTITY	Changes in expression and function of syncytin and its receptor , amino_acid transport system B -LRB- 0 -RRB- -LRB- ASCT2 -RRB- , in human placental_choriocarcinoma BeWo cells during syncytialization .
12584318	0	amino_acid	113,123	ASCT2	99,104	amino acid	ASCT2	CHEBI:33704	20514(Tax:10090)	Chemical	Gene	transporters|compound|START_ENTITY transporters|compound|END_ENTITY	N-linked glycosylation and sequence changes in a critical negative control region of the ASCT1 and ASCT2 neutral amino_acid transporters determine their retroviral receptor functions .
15670919	0	amino_acid	63,73	ASCT2	49,54	amino acid	ASCT2	CHEBI:33704	6510	Chemical	Gene	site|amod|START_ENTITY analogues|dobj|site analogues|nmod|probes probes|nmod|END_ENTITY	Ngamma-aryl_glutamine analogues as probes of the ASCT2 neutral amino_acid transporter binding site .
17475673	0	amino_acid	45,55	ASCT2	68,73	amino acid	ASCT2	CHEBI:33704	292657(Tax:10116)	Chemical	Gene	transporter|amod|START_ENTITY transporter|dep|END_ENTITY	Underexpression of the Na + - dependent neutral amino_acid transporter ASCT2 in the spontaneously hypertensive rat kidney .
18162837	0	amino_acid	22,32	ASCT2	45,50	amino acid	ASCT2	CHEBI:33704	6510	Chemical	Gene	transporter|amod|START_ENTITY transporter|acl:relcl|downregulated downregulated|nsubjpass|END_ENTITY	Na + - dependent neutral amino_acid transporter ASCT2 is downregulated in seriously traumatized human intestinal epithelial cells .
19012749	0	amino_acid	37,47	ASCT2	68,73	amino acid	ASCT2	CHEBI:33704	20514(Tax:10090)	Chemical	Gene	transporter|amod|START_ENTITY distribution|nmod|transporter subtype|nsubj|distribution subtype|dobj|END_ENTITY	Cellular distribution of the neutral amino_acid transporter subtype ASCT2 in mouse brain .
24792914	0	amino_acid	38,48	ASCT2	61,66	amino acid	ASCT2	CHEBI:33704	20514(Tax:10090)	Chemical	Gene	facilitation|amod|START_ENTITY facilitation|compound|END_ENTITY	Inflammatory T cell responses rely on amino_acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation .
25297701	0	amino_acid	14,24	ASCT2	45,50	amino acid	ASCT2	CHEBI:33704	6510	Chemical	Gene	transporters|amod|START_ENTITY Expression|nmod|transporters Expression|appos|LAT1 LAT1|dep|END_ENTITY	Expression of amino_acid transporters -LRB- LAT1 , ASCT2 and xCT -RRB- as clinical significance in hepatocellular_carcinoma .
22785178	0	amino_acid	69,79	ASCT_2	95,101	amino acid	ASCT 2	CHEBI:33704	6510	Chemical	Gene	START_ENTITY|dobj|2 2|appos|END_ENTITY	cDNA sequence and tissue distribution of canine Na-dependent neutral amino_acid transporter 2 -LRB- ASCT_2 -RRB- .
21621508	0	amino_acid	11,21	AT1	7,10	amino acid	AT1	CHEBI:33704	24180(Tax:10116)	Chemical	Gene	transporter|amod|START_ENTITY transporter|compound|END_ENTITY	The B AT1 amino_acid transporter from rat kidney reconstituted in liposomes : kinetics and inactivation by methylmercury .
12388375	0	amino_acid	18,28	ATB_0	41,46	amino acid	ATB 0	CHEBI:33704	20514(Tax:10090)	Chemical	Gene	+|amod|START_ENTITY +|compound|END_ENTITY	Expression of the amino_acid transporter ATB_0 + in lung : possible role in luminal protein removal .
1348489	0	amino_acid	19,29	ATRC1	43,48	amino acid	ATRC1	CHEBI:33704	6541	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	The human cationic amino_acid transporter -LRB- ATRC1 -RRB- : physical and genetic mapping to 13q12-q14 .
22790597	0	amino_acid	21,31	Ace2	46,50	amino acid	Ace2	CHEBI:33704	70008(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Defective intestinal amino_acid absorption in Ace2 null mice .
2971812	10	amino_acid	2025,2035	Ad2	2055,2058	amino acid	E2A	CHEBI:33704	6929	Chemical	Gene	protein|amod|START_ENTITY protein|nmod|END_ENTITY	These findings implicated the E1A 289 amino_acid residue protein of Ad2 , a well-known transactivator , as the reactivating function of the endogenous , previously dormant , late E2A promoter-CAT gene assembly .
7729694	0	amino_acid	41,51	Adh	83,86	amino acid	Adh	CHEBI:33704	3771877(Tax:7227)	Chemical	Gene	START_ENTITY|nmod|region region|compound|END_ENTITY	Analysis of nucleotide substitutions and amino_acid conservation in the Drosophila Adh genomic region .
17227672	0	amino_acid	18,28	Ah_receptor	45,56	amino acid	Ah receptor	CHEBI:33704	196	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Identification of amino_acid residues in the Ah_receptor involved in ligand binding .
1846217	0	amino_acid	28,38	Ah_receptor	55,66	amino acid	Ah receptor	CHEBI:33704	11622(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Purification and N-terminal amino_acid sequence of the Ah_receptor from the C57BL/6J mouse .
1883381	0	amino_acid	42,52	Amphiregulin-associated_protein	0,31	amino acid	Amphiregulin-associated protein	CHEBI:33704	4192	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|dep|sequence	Amphiregulin-associated_protein : complete amino_acid sequence of a protein produced by the 12-0-tetradecanoylphorbol-13-acetate-treated human breast_adenocarcinoma cell line MCF-7 .
16787961	0	amino_acid	34,44	Angiotensin_II	0,14	amino acid	Angiotensin II	CHEBI:33704	183	Chemical	Gene	activity|amod|START_ENTITY fragments|nsubj|activity system|acl:relcl|fragments decreases|dobj|system decreases|nsubj|END_ENTITY	Angiotensin_II decreases system A amino_acid transporter activity in human placental villous fragments through AT1 receptor activation .
7499219	0	amino_acid	49,59	Angiotensin_II	0,14	amino acid	Angiotensin II	CHEBI:33704	24179(Tax:10116)	Chemical	Gene	stimulates|ccomp|START_ENTITY stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates system y + and cationic amino_acid transporter gene expression in cultured vascular smooth muscle cells .
2781509	0	amino_acid	22,32	Antithrombin	0,12	amino acid	Antithrombin	CHEBI:33704	462	Chemical	Gene	substitution|amod|START_ENTITY Chicago|appos|substitution Chicago|compound|END_ENTITY	Antithrombin Chicago , amino_acid substitution of arginine_393_to_histidine .
2917133	0	amino_acid	24,34	Antithrombin	0,12	amino acid	Antithrombin	CHEBI:33704	462	Chemical	Gene	substitution|amod|START_ENTITY Sheffield|dep|substitution Sheffield|compound|END_ENTITY	Antithrombin Sheffield : amino_acid substitution at the reactive site -LRB- Arg393_to_His -RRB- causing thrombosis .
3238650	0	amino_acid	28,38	Antithrombin	0,12	amino acid	Antithrombin	CHEBI:33704	462	Chemical	Gene	substitution|amod|START_ENTITY Milano|appos|substitution Milano|compound|END_ENTITY	Antithrombin Milano , single amino_acid substitution at the reactive site , Arg393_to_Cys .
5073740	0	amino_acid	4,14	B-protein	31,40	amino acid	B-protein	CHEBI:33704	7306	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The amino_acid sequence of the B-protein of bacteriophage ZJ-2 .
23954794	0	amino_acid	17,27	BAFF	31,35	amino acid	BAFF	CHEBI:33704	10673	Chemical	Gene	START_ENTITY|nmod|binding binding|compound|END_ENTITY	Identify the key amino_acid of BAFF binding with TACI .
9153753	0	amino_acid	19,29	BAP2	73,77	amino acid	BAP2	CHEBI:33704	852360(Tax:4932)	Chemical	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	The branched-chain amino_acid permease gene of Saccharomyces_cerevisiae , BAP2 , encodes the high-affinity leucine permease -LRB- S1 -RRB- .
11380625	7	amino_acid	1105,1115	BAT1	1130,1134	amino acid	THP1	CHEBI:33704	2736	Chemical	Gene	identity|amod|START_ENTITY identity|nmod|END_ENTITY	However the immunochemistry may be confounded by a recently described gene , DDXL , on chromosome 19 , which shares a 89 % amino_acid identity with BAT1 .
16358225	0	amino_acid	45,55	BAT1	71,75	amino acid	BAT1	CHEBI:33704	114612(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|1 1|appos|END_ENTITY	Co-localization and interaction of b0 , + - type amino_acid transporter 1 -LRB- BAT1 -RRB- with caveolin-1 in rat kidney .
19199104	0	amino_acid	22,32	BAT1	0,4	amino acid	BAT1	CHEBI:33704	814645(Tax:3702)	Chemical	Gene	transporter|amod|START_ENTITY END_ENTITY|appos|transporter	BAT1 , a bidirectional amino_acid transporter in Arabidopsis .
12431996	2	amino_acid	468,478	BRCA1	491,496	amino acid	BRCA1	CHEBI:33704	672	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Here we report that the E3 ligase activity of the N-terminal 110 amino_acid residues of BRCA1 , which encodes a stable domain containing the RING finger , as well as that of the full-length BRCA1 , was significantly enhanced by the BARD1 protein -LRB- residues 8-142 -RRB- , whose RING finger domain itself lacked Ub ligase activity in vitro .
3606570	0	amino_acid	9,19	BSP-A3	32,38	amino acid	BSP-A3	CHEBI:33704	317695(Tax:9913)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Complete amino_acid sequence of BSP-A3 from bovine seminal plasma .
11818025	0	amino_acid	297,307	BTBD1	20,25	amino acid	BTBD1	CHEBI:33704	53339	Chemical	Gene	START_ENTITY|nsubj|Characterization Characterization|nmod|END_ENTITY	Characterization of BTBD1 and BTBD2 , two similar BTB-domain-containing Kelch-like proteins that interact with Topoisomerase I. BACKGROUND : Two-hybrid screening for proteins that interact with the core domain of human topoisomerase I identified two novel proteins , BTBD1 and BTBD2 , which share 80 % amino_acid identities .
1737750	0	amino_acid	18,28	C-reactive_protein	45,63	amino acid	C-reactive protein	CHEBI:33704	25419(Tax:10116)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Derivation of the amino_acid sequence of rat C-reactive_protein from cDNA cloning with additional studies on the nature of its dimeric component .
2426265	0	amino_acid	4,14	C-reactive_protein	35,53	amino acid	C-reactive protein	CHEBI:33704	1401	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The amino_acid sequence of Limulus C-reactive_protein .
6303394	0	amino_acid	9,19	C1-r	85,89	amino acid	C1-r	CHEBI:33704	715	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Complete amino_acid sequence of the catalytic chain of human complement subcomponent C1-r .
1706597	1	amino_acid	139,149	C1q	168,171	amino acid	C1q	CHEBI:33704	712	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	The complete derived amino_acid sequence of human C1q .
8172565	3	amino_acid	685,695	C1q	729,732	amino acid	C1q	CHEBI:33704	712	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|chain chain|nmod|END_ENTITY	Additionally , the amino_acid sequence of the A chain of human C1q displays properties that are characteristic for integral type II membrane proteins .
3036070	0	amino_acid	9,19	C1r	89,92	amino acid	C1r	CHEBI:33704	715	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Complete amino_acid sequence of the A chain of human complement-classical-pathway enzyme C1r .
1325680	0	amino_acid	116,126	C4b-binding_protein	166,185	amino acid	C4b-binding protein	CHEBI:33704	722	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Expression and characterization of recombinant human protein S in heterologous cells -- studies of the interaction of amino_acid residues leu-608 to glu-612 with human C4b-binding_protein .
9116048	0	amino_acid	25,35	C5a	93,96	amino acid	C5a	CHEBI:33704	362119(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Nucleotide and corrected amino_acid sequence of the functional recombinant rat anaphylatoxin C5a .
11097853	0	amino_acid	7,17	C5a_receptor	93,105	amino acid	C5a receptor	CHEBI:33704	728	Chemical	Gene	responsible|nsubj|START_ENTITY responsible|nmod|ability ability|nmod|END_ENTITY	Single amino_acid of g -LRB- alpha16 -RRB- -LRB- Ala -LRB- 228 -RRB- -RRB- is responsible for the ability of chemoattractant C5a_receptor to induce G -LRB- alpha16 -RRB- - mediated inositol_phosphate release .
16230349	0	amino_acid	101,111	C5a_receptor	41,53	amino acid	C5a receptor	CHEBI:33704	728	Chemical	Gene	START_ENTITY|nsubj|characterization characterization|nmod|END_ENTITY	Molecular characterization of the gerbil C5a_receptor and identification of a transmembrane domain V amino_acid that is crucial for small molecule antagonist interaction .
6095282	0	amino_acid	40,50	C9	90,92	amino acid	C9	CHEBI:33704	735	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Nucleotide sequence of cDNA and derived amino_acid sequence of human complement component C9 .
9518650	0	amino_acid	34,44	CA1	78,81	amino acid	CA1	CHEBI:33704	759	Chemical	Gene	accumulation|amod|START_ENTITY accumulation|nmod|END_ENTITY	Ischemic_injury and extracellular amino_acid accumulation in hippocampal area CA1 are not dependent upon an intact septo-hippocampal pathway .
15596217	0	amino_acid	21,31	CA3	99,102	amino acid	CA3	CHEBI:33704	54232(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|region region|compound|END_ENTITY	Effect of excitatory amino_acid receptor agonists on penile erection after administration into the CA3 hippocampal region in the rat .
21722652	0	amino_acid	100,110	CAT-1	126,131	amino acid	CAT-1	CHEBI:33704	6541	Chemical	Gene	START_ENTITY|dobj|expression expression|appos|END_ENTITY	The biological effect of pharmacological treatment on dimethylaminohydrolases -LRB- DDAH-1 -RRB- and cationic amino_acid transporter-1 -LRB- CAT-1 -RRB- expression in patients with acute_congestive_heart_failure .
17234578	0	amino_acid	13,23	CAT1	37,41	amino acid	CAT1	CHEBI:33704	6541	Chemical	Gene	transporters|nsubj|START_ENTITY transporters|dobj|changes changes|compound|END_ENTITY	The cationic amino_acid transporters CAT1 and CAT3 mediate NMDA receptor activation-dependent changes in elaboration of neuronal processes via the mammalian_target_of_rapamycin mTOR pathway .
22705145	0	amino_acid	105,115	CAT1	131,135	amino acid	CAT1	CHEBI:33704	6541	Chemical	Gene	START_ENTITY|dobj|1 1|appos|END_ENTITY	Interaction of the cardiovascular risk marker asymmetric dimethylarginine -LRB- ADMA -RRB- with the human cationic amino_acid transporter 1 -LRB- CAT1 -RRB- .
23864433	0	amino_acid	60,70	CAT2	86,90	amino acid	CAT2	CHEBI:33704	6542	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Transport of asymmetric dimethylarginine -LRB- ADMA -RRB- by cationic amino_acid transporter 2 -LRB- CAT2 -RRB- , organic_cation_transporter_2 -LRB- OCT2 -RRB- and multidrug_and_toxin_extrusion_protein_1 -LRB- MATE1 -RRB- .
10220557	0	amino_acid	7,17	CCK	164,167	amino acid	CCK	CHEBI:33704	885	Chemical	Gene	START_ENTITY|parataxis|confers confers|nmod|END_ENTITY	Single amino_acid substitution of serine82_to_asparagine in first intracellular loop of human cholecystokinin _ -LRB- CCK -RRB- - B_receptor confers full cyclic_AMP responses to CCK and gastrin .
2880725	0	amino_acid	28,38	CD2	74,77	amino acid	CD2	CHEBI:33704	101106727	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Purification and N-terminal amino_acid sequence of the human T lymphocyte CD2 -LRB- T11 -RRB- surface antigen .
10762644	0	amino_acid	39,49	CD24	69,73	amino acid	CD24	CHEBI:33704	100133941	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Identification and characterization of amino_acid starvation-induced CD24 gene in MCF-7 human breast_cancer cells .
24016298	0	amino_acid	66,76	CD8	9,12	amino acid	CD8	CHEBI:33704	925	Chemical	Gene	START_ENTITY|nsubj|responses responses|compound|END_ENTITY	Elevated CD8 T cell responses in type_1_diabetes patients to a 13 amino_acid coeliac-active peptide from a-gliadin .
9683270	0	amino_acid	7,17	CDR2	40,44	amino acid	CDR2	CHEBI:33704	1039	Chemical	Gene	substitutions|amod|START_ENTITY substitutions|nmod|END_ENTITY	Single amino_acid substitutions in V -LRB- H -RRB- CDR2 are sufficient to generate or enhance the specificity of two forms of an anti-arsonate antibody variable region for DNA .
10600006	0	amino_acid	79,89	CDR3	67,71	amino acid	CDR3	CHEBI:33704	8163	Chemical	Gene	substitutions|amod|START_ENTITY substitutions|compound|END_ENTITY	Noncanonical Valpha24JalphaQ T cells with conservative alpha chain CDR3 region amino_acid substitutions are restricted by CD1d .
1380535	0	amino_acid	9,19	CDR3	32,36	amino acid	CDR3	CHEBI:33704	8163	Chemical	Gene	mutation|amod|START_ENTITY mutation|nmod|END_ENTITY	A single amino_acid mutation in CDR3 of the 3-14-9 L chain abolished expression of the IDA 10-defined idiotope and antigen binding .
9013084	0	amino_acid	138,148	CDR3	161,165	amino acid	CDR3	CHEBI:33704	8163	Chemical	Gene	profiles|amod|START_ENTITY profiles|nmod|regions regions|nummod|END_ENTITY	Molecular analysis of the T-cell receptor beta-chain repertoire in early rheumatoid_arthritis : heterogeneous TCRBV gene usage with shared amino_acid profiles in CDR3 regions of T lymphocytes in multiple synovial tissue needle biopsies from the same joint .
9263007	0	amino_acid	86,96	CDR3	112,116	amino acid	CDR3	CHEBI:33704	8163	Chemical	Gene	composition|amod|START_ENTITY composition|nmod|END_ENTITY	Skewing of TCR V genes to CD4 + and CD8 + subsets of T lymphocytes is not determined by amino_acid composition of CDR3 .
9352355	0	amino_acid	148,158	CDR3	21,25	amino acid	CDR3	CHEBI:33704	8163	Chemical	Gene	sequences|amod|START_ENTITY selection|nmod|sequences evidence|nmod|selection Ig|dep|evidence Ig|acl:relcl|display display|nsubj|regions regions|compound|END_ENTITY	Human Ig heavy chain CDR3 regions in adult bone marrow pre-B cells display an adult phenotype of diversity : evidence for structural selection of DH amino_acid sequences .
9385345	0	amino_acid	29,39	CDR3	40,44	amino acid	CDR3	CHEBI:33704	8163	Chemical	Gene	START_ENTITY|dobj|domains domains|nummod|END_ENTITY	Evidence for selection of 11 amino_acid CDR3 domains in V kappa III-derived immunoglobulin light chains in Kawasaki_disease .
9576622	0	amino_acid	10,20	CDR3	54,58	amino acid	CDR3	CHEBI:33704	110334(Tax:10090)	Chemical	Gene	substitutions|amod|START_ENTITY Effect|nmod|substitutions Effect|nmod|END_ENTITY	Effect of amino_acid substitutions in the heavy chain CDR3 of an autoantibody on its reactivity .
22259020	0	amino_acid	28,38	CLV3	66,70	amino acid	CLV3	CHEBI:33704	817267(Tax:3702)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Contributions of individual amino_acid residues to the endogenous CLV3 function in shoot apical meristem maintenance in Arabidopsis .
22946184	0	amino_acid	58,68	CO2	1,4	amino acid	CO2	CHEBI:33704	717	Chemical	Gene	absorption|nmod|START_ENTITY absorption|compound|END_ENTITY	-LSB- CO2 absorption and regeneration performance of a natural amino_acid and its potassium_salt -RSB- .
23042720	0	amino_acid	39,49	CO2	10,13	amino acid	CO2	CHEBI:33704	717	Chemical	Gene	salts|amod|START_ENTITY capture|nmod|salts capture|nsubj|END_ENTITY	Equimolar CO2 capture by N-substituted amino_acid salts and subsequent conversion .
24358463	0	amino_acid	33,43	CO2	73,76	amino acid	CO2	CHEBI:33704	717	Chemical	Gene	liquid|amod|START_ENTITY containing|dobj|liquid containing|nmod|media media|compound|END_ENTITY	Polymeric ion-gels containing an amino_acid ionic liquid for facilitated CO2 transport media .
5836014	0	amino_acid	34,44	CO2	15,18	amino acid	CO2	CHEBI:33704	717	Chemical	Gene	synthesis|amod|START_ENTITY END_ENTITY|nmod|synthesis	Utilization of CO2 and acetate in amino_acid synthesis by Streptococcus bovis .
8372631	0	amino_acid	23,33	CSF	19,22	amino acid	CSF	CHEBI:33704	1437	Chemical	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Fasting plasma and CSF amino_acid levels in amyotrophic_lateral_sclerosis : a subtype analysis .
7204387	0	amino_acid	4,14	CTL-1	45,50	amino acid	CTL-1	CHEBI:33704	513971(Tax:9913)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The amino_acid sequence of residues 1-104 of CTL-1 , a bovine H1 histone .
2167439	0	amino_acid	9,19	CUP2	30,34	amino acid	CUP2	CHEBI:33704	852710(Tax:4932)	Chemical	Gene	change|amod|START_ENTITY change|nmod|END_ENTITY	A single amino_acid change in CUP2 alters its mode of DNA binding .
11023662	0	amino_acid	123,133	CXCR2	146,151	amino acid	CXCR2	CHEBI:33704	3579	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Interleukin_8 , neutrophil-activating_peptide-2 and GRO-alpha bind to and elicit cell activation via specific and different amino_acid residues of CXCR2 .
15126570	0	amino_acid	37,47	CYP21	69,74	amino acid	CYP21	CHEBI:33704	1589	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Functional analysis of two recurrent amino_acid substitutions in the CYP21 gene from Italian patients with congenital_adrenal_hyperplasia .
15333516	0	amino_acid	27,37	CYP2A13	56,63	amino acid	CYP2A13	CHEBI:33704	1553	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Identification of critical amino_acid residues of human CYP2A13 for the metabolic activation of 4 - -LRB- methylnitrosamino -RRB- -1 - -LRB- 3-pyridyl -RRB- -1 - butanone , a tobacco-specific carcinogen .
9614060	0	amino_acid	33,43	Cat1	82,86	amino acid	Cat1	CHEBI:33704	64177(Tax:10090)	Chemical	Gene	START_ENTITY|ccomp|compensates compensates|nmod|lines lines|amod|END_ENTITY	Increased Cat3-mediated cationic amino_acid transport functionally compensates in Cat1 knockout cell lines .
8568335	0	amino_acid	29,39	Cholecystokinin	0,15	amino acid	Cholecystokinin	CHEBI:33704	885	Chemical	Gene	secretion|amod|START_ENTITY END_ENTITY|nmod|secretion	Cholecystokinin -LRB- CCK -RRB- in the amino_acid uptake and enzyme protein secretion by the pancreas in humans .
8929974	0	amino_acid	77,87	Corticotropin-releasing_factor	0,30	amino acid	Corticotropin-releasing factor	CHEBI:33704	81648(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|modulates modulates|amod|END_ENTITY	Corticotropin-releasing_factor modulates basal and stress-induced excitatory amino_acid release in the locus coeruleus of conscious rats .
12624756	0	amino_acid	57,67	D-amino-acid_oxidase	79,99	amino acid	D-amino-acid oxidase	CHEBI:33704	114027(Tax:10116)	Chemical	Gene	residue|amod|START_ENTITY residue|nmod|END_ENTITY	Hamster D-amino-acid_oxidase cDNA : rodents lack the 27th amino_acid residue in D-amino-acid_oxidase .
2615592	4	amino_acid	463,473	DBI	492,495	amino acid	DBI	CHEBI:33704	768330(Tax:9913)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Comparison of the amino_acid sequence of mouse DBI to that for human , rat and bovine DBI shows that the size of DBI is conserved at 87 amino_acids in all of these mammals .
25597765	0	amino_acid	73,83	DDC	104,107	amino acid	DDC	CHEBI:33704	1644	Chemical	Gene	variant|amod|START_ENTITY variant|appos|END_ENTITY	Syndromic_intellectual_disability : A new phenotype caused by an aromatic amino_acid decarboxylase gene -LRB- DDC -RRB- variant .
11038260	0	amino_acid	51,61	DM20	81,85	amino acid	DM20	CHEBI:33704	64264(Tax:7955)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Phylogenetic relation of lungfish indicated by the amino_acid sequence of myelin DM20 .
6436055	0	amino_acid	4,14	DNA_binding_protein	35,54	amino acid	DNA binding protein	CHEBI:33704	24869074	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The amino_acid sequence of a small DNA_binding_protein from the archaebacterium Sulfolobus_solfataricus .
10432439	0	amino_acid	17,27	DRB1	12,16	amino acid	DRB1	CHEBI:33704	3123	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	The role of DRB1 amino_acid residue differences on donor-specific antibody production and acute rejection after cadaveric renal transplant .
350268	0	amino_acid	29,39	Dihydrofolate_reductase	0,23	amino acid	Dihydrofolate reductase	CHEBI:33704	13906554	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|dep|sequence	Dihydrofolate_reductase : the amino_acid sequence of the enzyme from a methotrexate-resistant mutant of Escherichia_coli .
15259055	0	amino_acid	78,88	E-cadherin	99,109	amino acid	E-cadherin	CHEBI:33704	999	Chemical	Gene	change|amod|START_ENTITY change|nmod|END_ENTITY	Dynamics of cell adhesion and motility in living cells is altered by a single amino_acid change in E-cadherin fused to enhanced green fluorescent protein .
12296385	0	amino_acid	46,56	EAAC2	84,89	amino acid	EAAC2	CHEBI:33704	20510(Tax:10090)	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	A mRNA molecule encoding truncated excitatory amino_acid carrier 1 -LRB- EAAC1 -RRB- protein -LRB- EAAC2 -RRB- is transcribed from an independent promoter but not an alternative splicing event .
10899959	0	amino_acid	131,141	EAAT1	155,160	amino acid	EAAT1	CHEBI:33704	29483(Tax:10116)	Chemical	Gene	START_ENTITY|ccomp|transporters transporters|dobj|END_ENTITY	Preconditioning with cortical_spreading_depression decreases intraischemic cerebral glutamate levels and down-regulates excitatory amino_acid transporters EAAT1 and EAAT2 from rat cerebal cortex plasma membranes .
11784698	0	amino_acid	65,75	EAAT1	91,96	amino acid	EAAT1	CHEBI:33704	6507	Chemical	Gene	START_ENTITY|dobj|1 1|appos|END_ENTITY	The expression of the glutamate re-uptake transporter excitatory amino_acid transporter 1 -LRB- EAAT1 -RRB- in the normal human CNS and in motor_neurone_disease : an immunohistochemical study .
11826152	0	amino_acid	60,70	EAAT1	86,91	amino acid	EAAT1	CHEBI:33704	6507	Chemical	Gene	START_ENTITY|dobj|1 1|appos|END_ENTITY	Aberrant expression of the glutamate transporter excitatory amino_acid transporter 1 -LRB- EAAT1 -RRB- in Alzheimer 's _ disease .
14713304	0	amino_acid	47,57	EAAT1	73,78	amino acid	EAAT1	CHEBI:33704	6507	Chemical	Gene	START_ENTITY|dobj|transporter transporter|appos|END_ENTITY	Transcriptional regulation of human excitatory amino_acid transporter 1 -LRB- EAAT1 -RRB- : cloning of the EAAT1 promoter and characterization of its basal and inducible activity in human astrocytes .
14713304	0	amino_acid	47,57	EAAT1	96,101	amino acid	EAAT1	CHEBI:33704	6507	Chemical	Gene	START_ENTITY|dobj|transporter transporter|dep|cloning cloning|nmod|promoter promoter|compound|END_ENTITY	Transcriptional regulation of human excitatory amino_acid transporter 1 -LRB- EAAT1 -RRB- : cloning of the EAAT1 promoter and characterization of its basal and inducible activity in human astrocytes .
15135308	0	amino_acid	53,63	EAAT1	77,82	amino acid	EAAT1	CHEBI:33704	6507	Chemical	Gene	START_ENTITY|dobj|assay assay|amod|transporters transporters|dep|END_ENTITY	Pharmacological characterization of human excitatory amino_acid transporters EAAT1 , EAAT2 and EAAT3 in a fluorescence-based membrane potential assay .
17428968	3	amino_acid	420,430	EAAT1	446,451	amino acid	EAAT2	CHEBI:33704	6506	Chemical	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	Here , we investigate the effect of hypoxia on activity and expression of the key glutamate transporters excitatory amino_acid transporter 1 -LRB- EAAT1 -RRB- -LSB- GLAST -LRB- glutamate-aspartate_transporter -RRB- -RSB- and EAAT2 -LSB- GLT-1 -LRB- glutamate_transporter_1 -RRB- -RSB- .
22594609	0	amino_acid	62,72	EAAT1	96,101	amino acid	EAAT1	CHEBI:33704	6507	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Structure-activity relationship study of selective excitatory amino_acid transporter subtype 1 -LRB- EAAT1 -RRB- inhibitor 2-amino-4 - -LRB- 4-methoxyphenyl -RRB- -7 - -LRB- naphthalen-1-yl -RRB- -5 - oxo-5 ,6,7,8 - tetrahydro-4H-chromene-3-carbonitrile -LRB- UCPH-101 -RRB- and absolute configurational assignment using infrared and vibrational circular dichroism spectroscopy in combination with ab initio Hartree-Fock calculations .
23325245	0	amino_acid	39,49	EAAT1	135,140	amino acid	EAAT1	CHEBI:33704	6507	Chemical	Gene	transporter|amod|START_ENTITY modulation|nmod|transporter exerts|nsubj|modulation exerts|dobj|inhibition inhibition|nmod|END_ENTITY	Allosteric modulation of an excitatory amino_acid transporter : the subtype-selective inhibitor UCPH-101 exerts sustained inhibition of EAAT1 through an intramonomeric site in the trimerization domain .
25064059	0	amino_acid	27,37	EAAT1	51,56	amino acid	EAAT1	CHEBI:33704	6507	Chemical	Gene	START_ENTITY|dobj|transporters transporters|nummod|END_ENTITY	Localization of excitatory amino_acid transporters EAAT1 and EAAT2 in human postmortem cortex : a light and electron microscopic study .
8001975	0	amino_acid	31,41	EAAT1	60,65	amino acid	EAAT1	CHEBI:33704	6507	Chemical	Gene	START_ENTITY|dobj|maps maps|appos|END_ENTITY	The mouse and human excitatory amino_acid transporter gene -LRB- EAAT1 -RRB- maps to mouse chromosome 15 and a region of syntenic homology on human chromosome 5 .
11011030	0	amino_acid	75,85	EAAT2	99,104	amino acid	EAAT2	CHEBI:33704	6506	Chemical	Gene	START_ENTITY|dobj|transporter transporter|appos|END_ENTITY	A new structural class of subtype-selective inhibitor of cloned excitatory amino_acid transporter , EAAT2 .
11343855	0	amino_acid	29,39	EAAT2	55,60	amino acid	EAAT2	CHEBI:33704	6506	Chemical	Gene	START_ENTITY|dobj|2 2|appos|END_ENTITY	The expression of excitatory amino_acid transporter 2 -LRB- EAAT2 -RRB- in forensic autopsy cases .
12578975	0	amino_acid	105,115	EAAT2	131,136	amino acid	EAAT2	CHEBI:33704	6506	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Insights into glutamate transport regulation in human astrocytes : cloning of the promoter for excitatory amino_acid transporter 2 -LRB- EAAT2 -RRB- .
15135308	0	amino_acid	53,63	EAAT2	84,89	amino acid	EAAT2	CHEBI:33704	6506	Chemical	Gene	START_ENTITY|dobj|assay assay|amod|transporters transporters|dep|EAAT1 EAAT1|nummod|END_ENTITY	Pharmacological characterization of human excitatory amino_acid transporters EAAT1 , EAAT2 and EAAT3 in a fluorescence-based membrane potential assay .
15187084	0	amino_acid	142,152	EAAT2	62,67	amino acid	EAAT2	CHEBI:33704	20511(Tax:10090)	Chemical	Gene	localization|amod|START_ENTITY importance|nmod|localization Association|dep|importance Association|amod|END_ENTITY	Association of excitatory amino_acid transporters , especially EAAT2 , with cholesterol-rich lipid raft microdomains : importance for excitatory amino_acid transporter localization and function .
15187084	0	amino_acid	26,36	EAAT2	62,67	amino acid	EAAT2	CHEBI:33704	20511(Tax:10090)	Chemical	Gene	transporters|amod|START_ENTITY Association|nmod|transporters Association|amod|END_ENTITY	Association of excitatory amino_acid transporters , especially EAAT2 , with cholesterol-rich lipid raft microdomains : importance for excitatory amino_acid transporter localization and function .
18620031	0	amino_acid	39,49	EAAT2	65,70	amino acid	EAAT2	CHEBI:33704	29482(Tax:10116)	Chemical	Gene	START_ENTITY|ccomp|enhances enhances|nsubj|2 2|appos|END_ENTITY	Selective overexpression of excitatory amino_acid transporter 2 -LRB- EAAT2 -RRB- in astrocytes enhances neuroprotection from moderate but not severe hypoxia-ischemia .
18805467	0	amino_acid	147,157	EAAT2	173,178	amino acid	EAAT2	CHEBI:33704	20511(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|2 2|appos|END_ENTITY	A quantitative assessment of glutamate uptake into hippocampal synaptic terminals and astrocytes : new insights into a neuronal role for excitatory amino_acid transporter 2 -LRB- EAAT2 -RRB- .
18838545	7	amino_acid	1093,1103	EAAT2	1119,1124	amino acid	EAAT2	CHEBI:33704	6506	Chemical	Gene	transporter|amod|START_ENTITY loss|nmod|transporter loss|appos|END_ENTITY	Without complement , astrocytic membranes remain intact , but AQP4 is endocytosed with concomitant loss of Na -LRB- + -RRB- - dependent glutamate transport and loss of the excitatory amino_acid transporter 2 -LRB- EAAT2 -RRB- .
20688910	0	amino_acid	44,54	EAAT2	121,126	amino acid	EAAT2	CHEBI:33704	6506	Chemical	Gene	transporter-2|amod|START_ENTITY variants|nmod|transporter-2 form|nsubj|variants form|nmod|END_ENTITY	Exon-skipping splice variants of excitatory amino_acid transporter-2 -LRB- EAAT2 -RRB- form heteromeric complexes with full-length EAAT2 .
20688910	0	amino_acid	44,54	EAAT2	70,75	amino acid	EAAT2	CHEBI:33704	6506	Chemical	Gene	transporter-2|amod|START_ENTITY transporter-2|appos|END_ENTITY	Exon-skipping splice variants of excitatory amino_acid transporter-2 -LRB- EAAT2 -RRB- form heteromeric complexes with full-length EAAT2 .
21792905	0	amino_acid	19,29	EAAT2	45,50	amino acid	EAAT2	CHEBI:33704	6506	Chemical	Gene	transporter-2|amod|START_ENTITY transporter-2|appos|END_ENTITY	Role of excitatory amino_acid transporter-2 -LRB- EAAT2 -RRB- and glutamate in neurodegeneration : opportunities for developing novel therapeutics .
26046374	0	amino_acid	146,156	EAAT2	172,177	amino acid	EAAT2	D000596	6506	Chemical	Gene	START_ENTITY|dobj|2 2|appos|END_ENTITY	The peroxisome_proliferator_activated_receptor_gamma agonist pioglitazone increases functional expression of the glutamate transporter excitatory amino_acid transporter 2 -LRB- EAAT2 -RRB- in human glioblastoma cells .
11472204	0	amino_acid	115,125	EAAT3	145,150	amino acid	EAAT3	CHEBI:33704	6505	Chemical	Gene	EAAC1|amod|START_ENTITY EAAC1|appos|END_ENTITY	A rational approach to the design of selective substrates and potent nontransportable inhibitors of the excitatory amino_acid transporter EAAC1 -LRB- EAAT3 -RRB- .
25275463	0	amino_acid	38,48	EAAT3	64,69	amino acid	EAAT3	CHEBI:33704	6505	Chemical	Gene	START_ENTITY|dobj|3 3|appos|END_ENTITY	Cysteine transport through excitatory amino_acid transporter 3 -LRB- EAAT3 -RRB- .
20519505	0	amino_acid	94,104	EAAT4	120,125	amino acid	EAAT4	CHEBI:33704	6511	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	A conserved aspartate determines pore properties of anion channels associated with excitatory amino_acid transporter 4 -LRB- EAAT4 -RRB- .
10799302	0	amino_acid	40,50	EC1	63,66	amino acid	EC1	CHEBI:33704	4819	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Mutation analysis of cadherin-4 reveals amino_acid residues of EC1 important for the structure and function .
16103058	3	amino_acid	487,497	EGFR	512,516	amino acid	EGFR	CHEBI:33704	1956	Chemical	Gene	START_ENTITY|nmod|domain domain|amod|END_ENTITY	Previously , we showed that such resistance can be caused by a second mutation of the EGFR gene , leading to a T790M amino_acid change in the EGFR tyrosine kinase domain and also found that CL-387 ,785 , a specific and irreversible anilinoquinazoline EGFR inhibitor , was able to overcome this resistance on the biochemical level .
24015320	0	amino_acid	18,28	ERH	41,44	amino acid	ERH	CHEBI:33704	2079	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Identification of amino_acid residues of ERH required for its recruitment to nuclear speckles and replication foci in HeLa cells .
3892457	0	amino_acid	56,66	Elastin	0,7	amino acid	Elastin	CHEBI:33704	2006	Chemical	Gene	sequencing|amod|START_ENTITY covalent|nmod|sequencing covalent|nsubj|END_ENTITY	Elastin covalent structure as determined by solid phase amino_acid sequencing .
10918075	0	amino_acid	34,44	Epidermal_growth_factor	0,23	amino acid	Epidermal growth factor	CHEBI:33704	408035(Tax:9031)	Chemical	Gene	transport|amod|START_ENTITY regulates|dobj|transport regulates|nsubj|END_ENTITY	Epidermal_growth_factor regulates amino_acid transport in chick embryo hepatocytes via protein_kinase_C .
11278640	0	amino_acid	18,28	Erg	70,73	amino acid	Erg	CHEBI:33704	2078	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Identification of amino_acid residues in the ETS transcription factor Erg that mediate Erg-Jun/Fos-DNA ternary complex formation .
10698940	0	amino_acid	118,128	FKHR	174,178	amino acid	FKHR	CHEBI:33704	2308	Chemical	Gene	residue|amod|START_ENTITY residue|nmod|END_ENTITY	Differential regulation of gene expression by insulin and IGF-1 receptors correlates with phosphorylation of a single amino_acid residue in the forkhead transcription factor FKHR .
8747275	0	amino_acid	92,102	Fc_gamma_RI	127,138	amino acid	Fc gamma RI	CHEBI:33704	2209	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	The interaction between human Fc_gamma_RI and the gamma-chain is mediated solely via the 21 amino_acid transmembrane domain of Fc_gamma_RI .
8555090	0	amino_acid	7,17	Fc_gamma_receptor	30,47	amino acid	Fc gamma receptor	CHEBI:33704	2209	Chemical	Gene	mutation|amod|START_ENTITY mutation|nmod|END_ENTITY	Single amino_acid mutation of Fc_gamma_receptor is associated with the development of heparin-induced thrombocytopenia .
11435303	0	amino_acid	60,70	Fibrinogen	0,10	amino acid	Fibrinogen	CHEBI:33704	2244	Chemical	Gene	substitutions|amod|START_ENTITY containing|dobj|substitutions variant|acl|containing XII|dep|variant XII|compound|END_ENTITY	Fibrinogen Milano XII : a dysfunctional variant containing 2 amino_acid substitutions , Aalpha R16C and gamma G165R .
12706644	0	amino_acid	68,78	Fibrinogen	0,10	amino acid	Fibrinogen	CHEBI:33704	2244	Chemical	Gene	exchange|amod|START_ENTITY fibrinogen|nmod|exchange variant|nmod|fibrinogen I|dep|variant I|compound|END_ENTITY	Fibrinogen Magdeburg I : a novel variant of human fibrinogen with an amino_acid exchange in the fibrinopeptide A -LRB- Aalpha 9 , Leu -- > Pro -RRB- .
6414212	0	amino_acid	211,221	Fibrinogen	0,10	amino acid	Fibrinogen	CHEBI:33704	2244	Chemical	Gene	analysis|amod|START_ENTITY assessed|nmod|analysis B|acl|assessed amount|nmod|B %|nmod|amount releases|dobj|% amount|acl:relcl|releases releases|dobj|amount releases|nsubj|Seattle Seattle|compound|END_ENTITY	Fibrinogen Seattle releases half the normal amount of fibrinopeptide B. Fibrinogen Seattle , a clinically silent , slow-clotting dysfibrinogen , releases 50 % of the normal amount of fibrinopeptide B as assessed by amino_acid analysis .
6648427	0	amino_acid	56,66	Fibrinogen	1,11	amino acid	Fibrinogen	CHEBI:33704	2244	Chemical	Gene	substitution|amod|START_ENTITY variant|nmod|substitution II|dep|variant II|compound|END_ENTITY	-LSB- Fibrinogen Bern II : hereditary fibrinogen variant with amino_acid substitution of arginine_replaced_by_histidine_in_position_16 of the A alpha chain -RSB- .
9630337	0	amino_acid	30,40	GABA_receptor	85,98	amino acid	GABA receptor	CHEBI:33704	11337	Chemical	Gene	START_ENTITY|nmod|sensitivity sensitivity|nmod|END_ENTITY	The effect of a transmembrane amino_acid on etomidate sensitivity of an invertebrate GABA_receptor .
3272162	0	amino_acid	26,36	GAP-43	6,12	amino acid	GAP-43	CHEBI:33704	14432(Tax:10090)	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|dep|sequence	Human GAP-43 : its deduced amino_acid sequence and chromosomal localization in mouse and human .
14673502	0	amino_acid	41,51	GATA-1b	64,71	amino acid	GATA-1b	CHEBI:33704	378511(Tax:8355)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	-LSB- Effects of site-directed mutagenesis at amino_acid residues of GATA-1b different from that of GATA-1a in Xenopus -RSB- .
24300109	0	amino_acid	107,117	GLAST	133,138	amino acid	GLAST	CHEBI:33704	29483(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|1 1|appos|END_ENTITY	Primary cultures of rat cortical microglia treated with nicotine increases in the expression of excitatory amino_acid transporter 1 -LRB- GLAST -RRB- via the activation of the a7 nicotinic acetylcholine receptor .
19201818	0	amino_acid	67,77	GLT-1	90,95	amino acid	GLT-1	CHEBI:33704	6506	Chemical	Gene	cell|amod|START_ENTITY cell|compound|END_ENTITY	The four major N - and C-terminal splice variants of the excitatory amino_acid transporter GLT-1 form cell surface homomeric and heteromeric assemblies .
7713316	0	amino_acid	28,38	GLUT2	73,78	amino acid	GLUT2	CHEBI:33704	6514	Chemical	Gene	START_ENTITY|nmod|glucose glucose|appos|END_ENTITY	Identification of two novel amino_acid polymorphisms in beta-cell/liver -LRB- GLUT2 -RRB- glucose transporter in Japanese subjects .
1520266	7	amino_acid	709,719	GLUT_7	732,738	amino acid	GLUT 2	CHEBI:33704	25351(Tax:10116)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The deduced amino_acid sequence of GLUT_7 shows 68 % identity with the deduced amino_acid sequence of rat liver GLUT_2 .
2204769	0	amino_acid	178,188	GM-CSF	205,211	amino acid	GM-CSF	CHEBI:33704	116630(Tax:10116)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Response of murine cell lines to an IL-1 / IL-2-induced factor in a rat/mouse T hybridoma -LRB- PC60 -RRB- : differential induction of cytokines by human IL-1_alpha and IL-1_beta and partial amino_acid sequence of rat GM-CSF .
25907991	0	amino_acid	4,14	GP5	42,45	amino acid	GP5	D000596	2814	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	The amino_acid residues at 102 and 104 in GP5 of porcine_reproductive_and_respiratory_syndrome_virus regulate viral neutralization susceptibility to the porcine serum neutralizing antibody .
10827258	0	amino_acid	99,109	GPA	95,98	amino acid	GPA	CHEBI:33704	2993	Chemical	Gene	substitutions|amod|START_ENTITY substitutions|compound|END_ENTITY	The low-frequency MNS blood group antigens Ny -LRB- a -RRB- -LRB- MNS18 -RRB- and Os -LRB- a -RRB- -LRB- MNS38 -RRB- are associated with GPA amino_acid substitutions .
11239234	0	amino_acid	69,79	GPB	97,100	amino acid	GPB	CHEBI:33704	2994	Chemical	Gene	substitutions|amod|START_ENTITY substitutions|nmod|END_ENTITY	The low-incidence MNS antigens M -LRB- v -RRB- , s -LRB- D -RRB- , and Mit arise from single amino_acid substitutions on GPB .
8471052	0	amino_acid	8,18	GSTM4	122,127	amino acid	GSTM4	CHEBI:33704	2948	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|nsubj|sequence	Deduced amino_acid sequence , gene structure and chromosomal location of a novel human class Mu glutathione_S-transferase , GSTM4 .
18599104	0	amino_acid	27,37	Gag	50,53	amino acid	Gag	CHEBI:33704	155030(Tax:11676)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Drug-associated changes in amino_acid residues in Gag p2 , p7 -LRB- NC -RRB- , and p6 -LRB- Gag -RRB- / p6 -LRB- Pol -RRB- in human_immunodeficiency_virus_type_1 _ -LRB- HIV-1 -RRB- _ display a dominant effect on replicative fitness and drug response .
10760522	0	amino_acid	42,52	Gal2	97,101	amino acid	Gal2	CHEBI:33704	850770(Tax:4932)	Chemical	Gene	START_ENTITY|nmod|transporter transporter|compound|END_ENTITY	Interaction between the critical aromatic amino_acid residues Tyr -LRB- 352 -RRB- and Phe -LRB- 504 -RRB- in the yeast Gal2 transporter .
8798585	0	amino_acid	36,46	GalNAc_kinase	22,35	amino acid	GalNAc kinase	CHEBI:33704	2585	Chemical	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification of the GalNAc_kinase amino_acid sequence .
19060912	0	amino_acid	32,42	Gap1	69,73	amino acid	Gap1	CHEBI:33704	853912(Tax:4932)	Chemical	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Transport and signaling via the amino_acid binding site of the yeast Gap1 amino_acid transceptor .
11312290	0	amino_acid	18,28	GluR1	41,46	amino acid	GluR1	CHEBI:33704	2890	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Identification of amino_acid residues in GluR1 responsible for ligand binding and desensitization .
2273091	0	amino_acid	200,210	GnRH	223,227	amino acid	GnRH	CHEBI:33704	2796	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Gonadotropin-releasing_hormone -LRB- GnRH -RRB- immunoreactive system in the brain of the dwarf gourami -LRB- Colisa lalia -RRB- as revealed by light microscopic immunocytochemistry using a monoclonal antibody to common amino_acid sequence of GnRH .
1141204	0	amino_acid	30,40	Growth_hormone	0,14	amino acid	Growth hormone	CHEBI:33704	81668(Tax:10116)	Chemical	Gene	transport|amod|START_ENTITY stimulation|nmod|transport stimulation|amod|END_ENTITY	Growth_hormone stimulation of amino_acid transport and utilization by the perfused rat liver .
12957138	0	amino_acid	60,70	Growth_hormone	0,14	amino acid	Growth hormone	CHEBI:33704	100356068(Tax:9986)	Chemical	Gene	systems|amod|START_ENTITY enhance|dobj|systems enhance|nsubj|END_ENTITY	Growth_hormone and epidermal_growth_factor together enhance amino_acid transport systems B -LRB- 0 , + -RRB- and A in remnant small intestine after massive enterectomy .
1329681	0	amino_acid	25,35	Growth_hormone	0,14	amino acid	Growth hormone	CHEBI:33704	2688	Chemical	Gene	transport|amod|START_ENTITY regulates|dobj|transport regulates|nsubj|END_ENTITY	Growth_hormone regulates amino_acid transport in human and rat liver .
14572788	0	amino_acid	60,70	Growth_hormone	0,14	amino acid	Growth hormone	CHEBI:33704	100356068(Tax:9986)	Chemical	Gene	systems|amod|START_ENTITY enhance|dobj|systems enhance|nsubj|END_ENTITY	Growth_hormone and epidermal_growth_factor together enhance amino_acid transport systems B0 , + and A in remnant small intestine after massive enterectomy .
8203982	0	amino_acid	24,34	Growth_hormone	0,14	amino acid	Growth hormone	CHEBI:33704	2688	Chemical	Gene	uptake|amod|START_ENTITY enhances|dobj|uptake enhances|nsubj|END_ENTITY	Growth_hormone enhances amino_acid uptake by the human small intestine .
8411286	0	amino_acid	50,60	Growth_hormone	0,14	amino acid	Growth hormone	CHEBI:33704	81668(Tax:10116)	Chemical	Gene	transport|amod|START_ENTITY Na|dep|transport Na|compound|END_ENTITY	Growth_hormone attenuates Na -LRB- + -RRB- - dependent hepatic amino_acid transport in endotoxemic rats .
9005964	0	amino_acid	25,35	Growth_hormone	0,14	amino acid	Growth hormone	CHEBI:33704	2688	Chemical	Gene	START_ENTITY|nsubj|modulates modulates|amod|END_ENTITY	Growth_hormone modulates amino_acid oxidation in the surgical patient : leucine kinetics during the fasted and fed state using moderate nitrogenous and caloric diet and recombinant human growth_hormone .
9063652	0	amino_acid	37,47	Growth_hormone	0,14	amino acid	Growth hormone	CHEBI:33704	102171600	Chemical	Gene	mixture|amod|START_ENTITY induced|nmod|mixture induced|nsubj|release release|amod|END_ENTITY	Growth_hormone release induced by an amino_acid mixture from primary cultured anterior pituitary cells of goats .
9565589	0	amino_acid	18,28	Gsalpha	41,48	amino acid	Gsalpha	CHEBI:33704	14683(Tax:10090)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Identification of amino_acid residues of Gsalpha critical to repression of adipogenesis .
7356686	0	amino_acid	42,52	Gyrate_atrophy	0,14	amino acid	Gyrate atrophy	CHEBI:33704	4942	Chemical	Gene	metabolism|amod|START_ENTITY END_ENTITY|dep|metabolism	Gyrate_atrophy of the choroid and retina : amino_acid metabolism and correction of hyperornithinemia with an arginine-deficient diet .
8954799	0	amino_acid	87,97	HCAT2	113,118	amino acid	HCAT2	CHEBI:33704	6542	Chemical	Gene	START_ENTITY|dobj|2 2|appos|END_ENTITY	Molecular cloning , tissue distribution , and chromosomal localization of human cationic amino_acid transporter 2 -LRB- HCAT2 -RRB- .
1272392	0	amino_acid	25,35	HLA-A	69,74	amino acid	HLA-A	CHEBI:33704	3105	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Isolation and N-terminal amino_acid sequence of membrane-bound human HLA-A and HLA-B antigens .
19033208	0	amino_acid	6,16	HLA-A	0,5	amino acid	HLA-A	CHEBI:33704	3105	Chemical	Gene	polymorphism|amod|START_ENTITY polymorphism|amod|END_ENTITY	HLA-A amino_acid polymorphism and delayed kidney allograft function .
21598828	0	amino_acid	24,34	HLA-DRB1	55,63	amino acid	HLA-DRB1	CHEBI:33704	3123	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Association of specific amino_acid sequence -LRB- QRRAA -RRB- of HLA-DRB1 * 0405 with rheumatoid_arthritis in a Tunisian population .
8772227	0	amino_acid	3,13	HRG	103,106	amino acid	HRG	CHEBI:33704	3273	Chemical	Gene	polymorphism|amod|START_ENTITY explains|nsubj|polymorphism explains|dobj|% %|nmod|variance variance|nmod|levels levels|compound|END_ENTITY	An amino_acid polymorphism in histidine-rich_glycoprotein -LRB- HRG -RRB- explains 59 % of the variance in plasma HRG levels .
8772227	0	amino_acid	3,13	HRG	59,62	amino acid	HRG	CHEBI:33704	3273	Chemical	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	An amino_acid polymorphism in histidine-rich_glycoprotein -LRB- HRG -RRB- explains 59 % of the variance in plasma HRG levels .
10806846	0	amino_acid	9,19	HSP70	35,40	amino acid	HSP70	CHEBI:33704	3308	Chemical	Gene	composition|amod|START_ENTITY composition|nmod|END_ENTITY	Study on amino_acid composition of HSP70 and the level of plasma free amino_acids of workers with long-term exposure to harmful factors .
14738768	4	amino_acid	742,752	HSP70	768,773	amino acid	HSP70	CHEBI:33704	3308	Chemical	Gene	domain|compound|START_ENTITY domain|nummod|END_ENTITY	The minimal 136 amino_acid , mycobacterial HSP70 peptide binding domain can generate CTL responses , and a single amino_acid mutant HSP70 designed to prevent peptide binding but retain stimulatory capacity has allowed us to separate antigen delivery from DC immunostimulation .
7588629	0	amino_acid	9,19	Hck	41,44	amino acid	Hck	CHEBI:33704	3055	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	A single amino_acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein .
18293509	0	amino_acid	53,63	Hsp47	25,30	amino acid	Hsp47	CHEBI:33704	871	Chemical	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Unexpected expression of Hsp47 , a replacement of one amino_acid -LRB- Val_7_Leu -RRB- in the amino terminal region , in cultured human tumorigenic cell lines .
16219135	0	amino_acid	37,47	Huh7	127,131	amino acid	Huh7	CHEBI:33704	284424	Chemical	Gene	START_ENTITY|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Biological effects of COOH-terminal amino_acid deletions of hepatitis_B virus X protein on hepatocellular_carcinoma cell line Huh7 -RSB- .
25446099	0	amino_acid	51,61	Huntingtin	72,82	amino acid	Huntingtin	CHEBI:33704	3064	Chemical	Gene	region|amod|START_ENTITY region|nmod|END_ENTITY	Chaperone protein HYPK interacts with the first 17 amino_acid region of Huntingtin and modulates mutant HTT-mediated aggregation and cytotoxicity .
9496249	0	amino_acid	14,24	IGF-I	67,72	amino acid	IGF-I	CHEBI:33704	3479	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Purification , amino_acid sequence and characterisation of kangaroo IGF-I .
12766800	0	amino_acid	28,38	IL-18	58,63	amino acid	IL-18	CHEBI:33704	3606	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Identification of important amino_acid residues for human IL-18 function by mutant construction .
11061285	6	amino_acid	774,784	IL-1beta	808,816	amino acid	IL-1beta	CHEBI:33704	3553	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|gene gene|compound|END_ENTITY	The predicted 254 amino_acid sequence of the second IL-1beta gene has 82 % similarity to the first gene , 45 % similarity to carp IL-1beta , and 40 % similarity to human IL-1beta .
8877726	0	amino_acid	25,35	IL-6	54,58	amino acid	IL-6	CHEBI:33704	3569	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Identification of single amino_acid residues of human IL-6 involved in receptor binding and signal initiation .
19724894	0	amino_acid	60,70	IRS-1	83,88	amino acid	IRS-1	CHEBI:33704	3667	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Effect of insulin levels on the phosphorylation of specific amino_acid residues in IRS-1 : implications for burn-induced insulin resistance .
11473060	0	amino_acid	4,14	IRS-2	36,41	amino acid	IRS-2	CHEBI:33704	8660	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	New amino_acid substitutions in the IRS-2 gene in Finnish and Chinese subjects with late-onset type 2 diabetes .
9013772	2	amino_acid	391,401	IRS-2	421,426	amino acid	IRS-2	CHEBI:33704	384783(Tax:10090)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	We recently reported the amino_acid sequence of murine IRS-2 ; in order to examine a potential genetic role for this molecule in disease , we isolated the murine IRS-2 gene and compared the expression pattern of IRS-2 against IRS-1 .
11834730	0	amino_acid	72,82	Insulin	0,7	amino acid	Insulin	CHEBI:33704	3630	Chemical	Gene	transporter|amod|START_ENTITY promotes|xcomp|transporter promotes|nsubj|END_ENTITY	Insulin promotes the cell surface recruitment of the SAT2/ATA2 system A amino_acid transporter from an endosomal compartment in skeletal muscle cells .
1542855	0	amino_acid	45,55	Insulin	0,7	amino acid	Insulin	CHEBI:33704	3630	Chemical	Gene	metabolism|compound|START_ENTITY action|nmod|metabolism action|compound|END_ENTITY	Insulin action on glucose and branched-chain amino_acid metabolism in cancer_cachexia : differential effects of insulin .
1674459	0	amino_acid	30,40	Insulin	0,7	amino acid	Insulin	CHEBI:33704	280829(Tax:9913)	Chemical	Gene	uptake|amod|START_ENTITY action|nmod|uptake action|compound|END_ENTITY	Insulin stimulatory action on amino_acid uptake in bovine adrenal cortex or glomerulosa zone .
18480057	0	amino_acid	34,44	Insulin	0,7	amino acid	Insulin	CHEBI:33704	3630	Chemical	Gene	START_ENTITY|nsubj|signaling signaling|compound|END_ENTITY	Insulin signaling and the general amino_acid control response .
18940943	0	amino_acid	24,34	Insulin	0,7	amino acid	Insulin	CHEBI:33704	3630	Chemical	Gene	stimulation|amod|START_ENTITY required|nmod|stimulation required|nsubjpass|END_ENTITY	Insulin is required for amino_acid stimulation of dual pathways for translational control in skeletal muscle in the late-gestation ovine fetus .
21492974	0	amino_acid	22,32	Insulin	0,7	amino acid	Insulin	CHEBI:33704	3630	Chemical	Gene	metabolism|compound|START_ENTITY resistance|nmod|metabolism resistance|compound|END_ENTITY	Insulin resistance of amino_acid and protein metabolism in type 2 diabetes .
24760501	0	amino_acid	40,50	Insulin	0,7	amino acid	Insulin	CHEBI:33704	3630	Chemical	Gene	SLC7A5/LAT1|amod|START_ENTITY abundance|nmod|SLC7A5/LAT1 increases|dobj|abundance increases|nsubj|END_ENTITY	Insulin increases mRNA abundance of the amino_acid transporter SLC7A5/LAT1 via an mTORC1-dependent mechanism in skeletal muscle cells .
27080554	0	amino_acid	46,56	Insulin	0,7	amino acid	Insulin	D000596	3630	Chemical	Gene	metabolism|amod|START_ENTITY associated|nmod|metabolism associated|nsubjpass|resistance resistance|compound|END_ENTITY	Insulin resistance is associated with altered amino_acid metabolism and adipose tissue dysfunction in normoglycemic women .
3517494	0	amino_acid	34,44	Insulin	0,7	amino acid	Insulin	CHEBI:33704	3630	Chemical	Gene	START_ENTITY|nsubj|stimulates stimulates|compound|END_ENTITY	Insulin stimulates branched chain amino_acid uptake and diminishes nitrogen flux from skeletal muscle of injured patients .
3530612	0	amino_acid	43,53	Insulin	0,7	amino acid	Insulin	CHEBI:33704	3630	Chemical	Gene	START_ENTITY|nsubj|resistance resistance|compound|END_ENTITY	Insulin resistance and regulation of serum amino_acid levels in myotonic_dystrophy .
4253389	0	amino_acid	18,28	Insulin	0,7	amino acid	Insulin	CHEBI:33704	3630	Chemical	Gene	transport|amod|START_ENTITY effect|nmod|transport effect|compound|END_ENTITY	Insulin effect on amino_acid transport in bone : dependence on protein synthesis and Na + .
4330966	0	amino_acid	9,19	Insulin	0,7	amino acid	Insulin	CHEBI:33704	3630	Chemical	Gene	metabolism|amod|START_ENTITY END_ENTITY|appos|metabolism	Insulin , amino_acid metabolism and lipolysis in isolated fat-cells .
5821033	0	amino_acid	18,28	Insulin	0,7	amino acid	Insulin	CHEBI:33704	3630	Chemical	Gene	transport|amod|START_ENTITY effect|nmod|transport effect|compound|END_ENTITY	Insulin effect on amino_acid transport in bone .
8546864	0	amino_acid	28,38	Insulin	0,7	amino acid	Insulin	CHEBI:33704	280829(Tax:9913)	Chemical	Gene	activity|amod|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	Insulin stimulates cationic amino_acid transport activity in the isolated perfused rat pancreas .
927624	0	amino_acid	30,40	Insulin	0,7	amino acid	Insulin	CHEBI:33704	3630	Chemical	Gene	metabolism|amod|START_ENTITY resistance|dep|metabolism resistance|compound|END_ENTITY	Insulin resistance in uremia : amino_acid metabolism .
9479555	0	amino_acid	20,30	Insulin	0,7	amino acid	Insulin	CHEBI:33704	280829(Tax:9913)	Chemical	Gene	infusions|amod|START_ENTITY response|nmod|infusions response|compound|END_ENTITY	Insulin response to amino_acid and glucose intravenous infusions in dairy cows : synergistic effect .
23891856	0	amino_acid	83,93	Interleukin-1b	0,14	amino acid	Interleukin-1b	CHEBI:33704	3553	Chemical	Gene	transport|amod|START_ENTITY inhibits|dobj|transport inhibits|nsubj|END_ENTITY	Interleukin-1b inhibits insulin signaling and prevents insulin-stimulated system A amino_acid transport in primary human trophoblasts .
1373632	0	amino_acid	31,41	KA-2	4,8	amino acid	KA-2	CHEBI:33704	24407(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY subunit|nmod|receptors subunit|compound|END_ENTITY	The KA-2 subunit of excitatory amino_acid receptors shows widespread expression in brain and forms ion channels with distantly related subunits .
23923038	0	amino_acid	46,56	Klotho	0,6	amino acid	Klotho	CHEBI:33704	9365	Chemical	Gene	sensitivity|nmod|START_ENTITY sensitivity|compound|END_ENTITY	Klotho sensitivity of the neuronal excitatory amino_acid transporters EAAT3 and EAAT4 .
2125007	0	amino_acid	13,23	L-histidine_decarboxylase	36,61	amino acid	L-histidine decarboxylase	CHEBI:33704	15186(Tax:10090)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	cDNA-derived amino_acid sequence of L-histidine_decarboxylase from mouse mastocytoma P-815 cells .
19617954	0	amino_acid	25,35	LAT-1	51,56	amino acid	LAT-1	CHEBI:33704	8140	Chemical	Gene	START_ENTITY|dobj|1 1|appos|END_ENTITY	Significance of system L amino_acid transporter 1 -LRB- LAT-1 -RRB- and 4F2_heavy_chain -LRB- 4F2hc -RRB- expression in human developing intestines .
10049700	0	amino_acid	34,44	LAT1	6,10	amino acid	LAT1	CHEBI:33704	8140	Chemical	Gene	transporter|amod|START_ENTITY subunit|nmod|transporter END_ENTITY|appos|subunit	Human LAT1 , a subunit of system L amino_acid transporter : molecular cloning and transport function .
11389679	0	amino_acid	38,48	LAT1	30,34	amino acid	LAT1	CHEBI:33704	8140	Chemical	Gene	transport|amod|START_ENTITY END_ENTITY|nmod|transport	Role of the System L permease LAT1 in amino_acid and iodothyronine transport in placenta .
11745822	0	amino_acid	21,31	LAT1	47,51	amino acid	LAT1	CHEBI:33704	50719(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|transporter transporter|appos|END_ENTITY	Expression of L-type amino_acid transporter 1 -LRB- LAT1 -RRB- and 4F2_heavy_chain -LRB- 4F2hc -RRB- in liver_tumor lesions of rat models .
11901210	0	amino_acid	61,71	LAT1	87,91	amino acid	LAT1	CHEBI:33704	734908(Tax:8355)	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Transport of amino_acid-related compounds mediated by L-type amino_acid transporter 1 -LRB- LAT1 -RRB- : insights into the mechanisms of substrate recognition .
12716435	0	amino_acid	59,69	LAT1	40,44	amino acid	LAT1	CHEBI:33704	20539(Tax:10090)	Chemical	Gene	mRNA|amod|START_ENTITY mRNA|compound|END_ENTITY	Hypoxia induces de-stabilization of the LAT1 large neutral amino_acid transporter mRNA in brain capillary endothelial cells .
12716435	1	amino_acid	223,233	LAT1	254,258	amino acid	LAT1	CHEBI:33704	20539(Tax:10090)	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|transporter transporter|compound|END_ENTITY	Blood-brain barrier -LRB- BBB -RRB- transport of large neutral amino_acids is mediated by the large neutral amino_acid transporter type 1 -LRB- LAT1 transporter -RRB- .
12824232	0	amino_acid	82,92	LAT1	106,110	amino acid	LAT1	CHEBI:33704	8140	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Identification and functional characterization of a Na + - independent large neutral amino_acid transporter , LAT1 , in human and rabbit cornea .
15274339	0	amino_acid	21,31	LAT1	47,51	amino acid	LAT1	CHEBI:33704	8140	Chemical	Gene	START_ENTITY|dobj|transporter transporter|appos|END_ENTITY	Expression of L-type amino_acid transporter 1 -LRB- LAT1 -RRB- and 4F2_heavy_chain -LRB- 4F2hc -RRB- in oral_squamous_cell_carcinoma and its precusor lesions .
15906366	0	amino_acid	21,31	LAT1	47,51	amino acid	LAT1	CHEBI:33704	20539(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|1 1|appos|END_ENTITY	Expression of L-type amino_acid transporter 1 -LRB- LAT1 -RRB- in esophageal_carcinoma .
16027961	0	amino_acid	28,38	LAT1	14,18	amino acid	LAT1	CHEBI:33704	8140	Chemical	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of LAT1 and LAT2 amino_acid transporters in human and rat intestinal epithelial cells .
16128699	0	amino_acid	43,53	LAT1	27,31	amino acid	LAT1	CHEBI:33704	100134831(Tax:9823)	Chemical	Gene	exchanger|amod|START_ENTITY END_ENTITY|appos|exchanger	Expression and function of LAT1 , a neutral amino_acid exchanger , in renal porcine epithelial cell line LLC-PK .
17489360	0	amino_acid	86,96	LAT1	110,114	amino acid	LAT1	CHEBI:33704	8140	Chemical	Gene	transporter|amod|START_ENTITY inhibiting|dobj|transporter cells|acl|inhibiting profiles|nmod|cells END_ENTITY|nsubj|profiles	Gene expression profiles in T24 human bladder_carcinoma cells by inhibiting an L-type amino_acid transporter , LAT1 .
17558306	0	amino_acid	29,39	LAT1	53,57	amino acid	LAT1	CHEBI:33704	8140	Chemical	Gene	polymorphisms|nmod|START_ENTITY transporters|nsubj|polymorphisms transporters|dobj|END_ENTITY	Genetic polymorphisms in the amino_acid transporters LAT1 and LAT2 in relation to the pharmacokinetics and side effects of melphalan .
18056335	0	amino_acid	7,17	LAT1	31,35	amino acid	LAT1	CHEBI:33704	8140	Chemical	Gene	START_ENTITY|dobj|transporters transporters|nummod|END_ENTITY	L-type amino_acid transporters LAT1 and LAT4 in cancer : uptake of 3-O-methyl-6-18F-fluoro-L-dopa in human adenocarcinoma and squamous_cell_carcinoma in vitro and in vivo .
18440724	0	amino_acid	21,31	LAT1	47,51	amino acid	LAT1	CHEBI:33704	8140	Chemical	Gene	START_ENTITY|dobj|1 1|appos|END_ENTITY	Expression of L-type amino_acid transporter 1 -LRB- LAT1 -RRB- in neuroendocrine_tumors of the lung .
18656534	0	amino_acid	31,41	LAT1	55,59	amino acid	LAT1	CHEBI:33704	8140	Chemical	Gene	role|nmod|START_ENTITY transporters|nsubj|role transporters|dobj|END_ENTITY	Pharmacokinetic role of L-type amino_acid transporters LAT1 and LAT2 .
18981585	0	amino_acid	53,63	LAT1	79,83	amino acid	LAT1	CHEBI:33704	50719(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|transporter transporter|appos|END_ENTITY	Evaluation of amino_acid-mustard transport as L-type amino_acid transporter 1 -LRB- LAT1 -RRB- - mediated alkylating agents .
19068093	0	amino_acid	34,44	LAT1	60,64	amino acid	LAT1	CHEBI:33704	8140	Chemical	Gene	transporter|amod|START_ENTITY transporter|dep|1 1|appos|END_ENTITY	Prognostic significance of L-type amino_acid transporter 1 -LRB- LAT1 -RRB- and 4F2_heavy_chain -LRB- CD98 -RRB- expression in early stage squamous cell carcinoma_of_the_lung .
19171406	0	amino_acid	34,44	LAT1	60,64	amino acid	LAT1	CHEBI:33704	8140	Chemical	Gene	START_ENTITY|dobj|1 1|appos|END_ENTITY	Prognostic significance of L-type amino_acid transporter 1 -LRB- LAT1 -RRB- and 4F2_heavy_chain -LRB- CD98 -RRB- expression in stage I pulmonary adenocarcinoma .
19347882	0	amino_acid	7,17	LAT1	33,37	amino acid	LAT1	CHEBI:33704	8140	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	L-type amino_acid transporter 1 -LRB- LAT1 -RRB- is frequently expressed in thymic_carcinomas but is absent in thymomas .
20466543	0	amino_acid	125,135	LAT1	156,160	amino acid	LAT1	CHEBI:33704	8140	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|system system|nummod|END_ENTITY	Regiospecific and conformationally restrained analogs of melphalan and DL-2-NAM-7 and their affinities for the large neutral amino_acid transporter -LRB- system LAT1 -RRB- of the blood-brain barrier .
20510678	0	amino_acid	19,29	LAT1	45,49	amino acid	LAT1	CHEBI:33704	8140	Chemical	Gene	START_ENTITY|dobj|1 1|appos|END_ENTITY	Impact of system L amino_acid transporter 1 -LRB- LAT1 -RRB- on proliferation of human ovarian_cancer cells : a possible target for combination therapy with anti-proliferative aminopeptidase inhibitors .
22185814	0	amino_acid	24,34	LAT1	50,54	amino acid	LAT1	CHEBI:33704	50719(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|1 1|appos|END_ENTITY	Up-regulation of L-type amino_acid transporter 1 -LRB- LAT1 -RRB- in cultured rat retinal capillary endothelial cells in response to glucose_deprivation .
22199264	0	amino_acid	7,17	LAT1	33,37	amino acid	LAT1	CHEBI:33704	8140	Chemical	Gene	START_ENTITY|dobj|expression expression|amod|1 1|dep|END_ENTITY	L-type amino_acid transporter 1 -LRB- LAT1 -RRB- expression in malignant pleural_mesothelioma .
22813728	0	amino_acid	26,36	LAT1	52,56	amino acid	LAT1	CHEBI:33704	8140	Chemical	Gene	START_ENTITY|ccomp|predicts predicts|nsubj|transporter transporter|appos|END_ENTITY	High expression of L-type amino_acid transporter 1 -LRB- LAT1 -RRB- predicts poor prognosis in pancreatic_ductal_adenocarcinomas .
23171689	0	amino_acid	7,17	LAT1	33,37	amino acid	LAT1	CHEBI:33704	8140	Chemical	Gene	START_ENTITY|dobj|expression expression|amod|1 1|dep|END_ENTITY	L-type amino_acid transporter 1 -LRB- LAT1 -RRB- expression in canine mammary_gland_tumors .
23516127	0	amino_acid	43,53	LAT1	69,73	amino acid	LAT1	CHEBI:33704	8140	Chemical	Gene	START_ENTITY|dobj|expression expression|amod|1 1|dep|END_ENTITY	Clinicopathological significance of L-type amino_acid transporter 1 -LRB- LAT1 -RRB- expression in patients with adenoid_cystic_carcinoma .
23696029	0	amino_acid	21,31	LAT1	47,51	amino acid	LAT1	CHEBI:33704	8140	Chemical	Gene	START_ENTITY|dobj|1 1|appos|END_ENTITY	The impact of L-type amino_acid transporter 1 -LRB- LAT1 -RRB- in human hepatocellular_carcinoma .
23896327	0	amino_acid	7,17	LAT1	33,37	amino acid	LAT1	CHEBI:33704	8140	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	L-type amino_acid transporter 1 -LRB- LAT1 -RRB- : a new therapeutic target for canine mammary_gland_tumour .
24143237	0	amino_acid	19,29	LAT1	45,49	amino acid	LAT1	CHEBI:33704	8140	Chemical	Gene	START_ENTITY|dobj|transporter-1 transporter-1|appos|END_ENTITY	Imaging the L-type amino_acid transporter-1 -LRB- LAT1 -RRB- with Zr-89 immunoPET .
25220100	0	amino_acid	21,31	LAT1	47,51	amino acid	LAT1	CHEBI:33704	8140	Chemical	Gene	START_ENTITY|dobj|1 1|appos|END_ENTITY	Expression of L-type amino_acid transporter 1 -LRB- LAT1 -RRB- as a prognostic and therapeutic indicator in multiple_myeloma .
25297701	0	amino_acid	14,24	LAT1	39,43	amino acid	LAT1	CHEBI:33704	8140	Chemical	Gene	transporters|amod|START_ENTITY Expression|nmod|transporters Expression|appos|END_ENTITY	Expression of amino_acid transporters -LRB- LAT1 , ASCT2 and xCT -RRB- as clinical significance in hepatocellular_carcinoma .
25305508	0	amino_acid	107,117	LAT1	133,137	amino acid	LAT1	CHEBI:33704	8140	Chemical	Gene	transporter|amod|START_ENTITY display|nmod|transporter display|nsubj|1 1|appos|END_ENTITY	Amino_acid_ester prodrugs conjugated to the a-carboxylic_acid group do not display affinity for the L-type amino_acid transporter 1 -LRB- LAT1 -RRB- .
25385314	0	amino_acid	9,19	LAT1	32,36	amino acid	LAT1	CHEBI:33704	8140	Chemical	Gene	START_ENTITY|ccomp|accumulates accumulates|nsubj|END_ENTITY	System L amino_acid transporter LAT1 accumulates O - -LRB- 2-fluoroethyl -RRB- - L-tyrosine -LRB- FET -RRB- .
25901202	0	amino_acid	45,55	LAT1	70,74	amino acid	LAT1	D000596	8140	Chemical	Gene	transporters|amod|START_ENTITY CD147|nmod|transporters Relationship|nmod|CD147 Relationship|appos|END_ENTITY	Relationship between CD147 and expression of amino_acid transporters -LRB- LAT1 and ASCT2 -RRB- in patients with pancreatic_cancer .
25908107	0	amino_acid	7,17	LAT1	33,37	amino acid	LAT1	D000596	8140	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	L-type amino_acid transporter 1 -LRB- LAT1 -RRB- expression in lymph_node_metastasis of gastric_carcinoma : Its correlation with size of metastatic lesion and Ki-67 labeling .
26237765	0	amino_acid	34,44	LAT1	60,64	amino acid	LAT1	D000596	8140	Chemical	Gene	START_ENTITY|dobj|expression expression|amod|1 1|dep|END_ENTITY	Prognostic significance of L-type amino_acid transporter 1 -LRB- LAT1 -RRB- expression in cutaneous_melanoma .
26256001	0	amino_acid	68,78	LAT1	0,4	amino acid	LAT1	D000596	8140	Chemical	Gene	transporter|amod|START_ENTITY unit|nmod|transporter unit|nsubj|END_ENTITY	LAT1 is the transport competent unit of the LAT1/CD98 heterodimeric amino_acid transporter .
26256001	0	amino_acid	68,78	LAT1	0,4	amino acid	LAT1	D000596	8140	Chemical	Gene	transporter|amod|START_ENTITY unit|nmod|transporter unit|nsubj|END_ENTITY	LAT1 is the transport competent unit of the LAT1/CD98 heterodimeric amino_acid transporter .
26337286	0	amino_acid	53,63	LAT1	79,83	amino acid	LAT1	D000596	50719(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|expression expression|amod|1 1|dep|END_ENTITY	Endotoxin-induced inflammation down-regulates L-type amino_acid transporter 1 -LRB- LAT1 -RRB- expression at the blood-brain barrier of male rats and mice .
10574970	0	amino_acid	46,56	LAT2	0,4	amino acid	LAT2	CHEBI:33704	7462	Chemical	Gene	transporter|amod|START_ENTITY END_ENTITY|appos|transporter	LAT2 , a new basolateral 4F2hc/CD98-associated amino_acid transporter of kidney and intestine .
24142711	0	amino_acid	15,25	LAT3	38,42	amino acid	LAT3	CHEBI:33704	9056	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Suppression of amino_acid transporter LAT3 expression on proliferation of K562 cells .
15659399	0	amino_acid	32,42	LAT4	18,22	amino acid	LAT4	CHEBI:33704	124935	Chemical	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification of LAT4 , a novel amino_acid transporter with system L activity .
16816136	0	amino_acid	61,71	LHT1	12,16	amino acid	LHT1	CHEBI:33704	834078(Tax:3702)	Chemical	Gene	uptake|amod|START_ENTITY transporter|nmod|uptake transporter|nsubj|END_ENTITY	Arabidopsis LHT1 is a high-affinity transporter for cellular amino_acid uptake in both root epidermis and leaf mesophyll .
9390441	0	amino_acid	39,49	LHT1	0,4	amino acid	LHT1	CHEBI:33704	834078(Tax:3702)	Chemical	Gene	transporter|amod|START_ENTITY END_ENTITY|appos|transporter	LHT1 , a lysine - and histidine-specific amino_acid transporter in arabidopsis .
21741381	10	amino_acid	1630,1640	LLP	1661,1664	amino acid	LLP	CHEBI:33704	84298	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Based on the results of the current studies , amino_acid sequence of catfish LLP is highly dissimilar to mammalian and fish leptin .
9037073	0	amino_acid	28,38	LMP1	23,27	amino acid	LMP1	CHEBI:33704	9260	Chemical	Gene	sequence|amod|START_ENTITY sequence|compound|END_ENTITY	The Epstein-Barr_virus LMP1 amino_acid sequence that engages tumor necrosis factor receptor associated factors is critical for primary B lymphocyte growth transformation .
11423119	0	amino_acid	22,32	LOX-1	75,80	amino acid	LOX-1	CHEBI:33704	4973	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Requirements of basic amino_acid residues within the lectin-like domain of LOX-1 for the binding of oxidized low-density lipoprotein .
25979827	0	amino_acid	25,35	Lat1	72,76	amino acid	Lat1	D000596	8140	Chemical	Gene	import|amod|START_ENTITY regulation|nmod|import state|nsubj|regulation state|nmod|END_ENTITY	Reciprocal regulation of amino_acid import and epigenetic state through Lat1 and EZH2 .
8407907	0	amino_acid	68,78	MCAT	44,48	amino acid	MCAT	CHEBI:33704	223722(Tax:10090)	Chemical	Gene	transporters|amod|START_ENTITY family|nmod|transporters family|amod|END_ENTITY	Characterization of the third member of the MCAT family of cationic amino_acid transporters .
12870677	0	amino_acid	48,58	MCT1	71,75	amino acid	MCT1	CHEBI:33704	6566	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	A 44-kDa of protein identical to the N-terminal amino_acid sequence of MCT1 in human circulation .
9092626	0	amino_acid	30,40	MTH1	60,64	amino acid	MTH1	CHEBI:33704	4521	Chemical	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	Significance of the conserved amino_acid sequence for human MTH1 protein with antimutator activity .
23165769	0	amino_acid	51,61	Mammalian_target_of_rapamycin	0,29	amino acid	Mammalian target of rapamycin	D000596	2475	Chemical	Gene	START_ENTITY|nsubj|modulates modulates|compound|END_ENTITY	Mammalian_target_of_rapamycin signalling modulates amino_acid uptake by regulating transporter cell surface abundance in primary human trophoblast cells .
1699607	0	amino_acid	55,65	Manganese_superoxide_dismutase	0,30	amino acid	Manganese superoxide dismutase	CHEBI:33704	6648	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|dep|sequence	Manganese_superoxide_dismutase : nucleotide and deduced amino_acid sequence of a cDNA encoding a new human transcript .
11853689	0	amino_acid	41,51	Methionine_synthase	0,19	amino acid	Methionine synthase	CHEBI:33704	81522(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|activity activity|compound|END_ENTITY	Methionine_synthase activity and sulphur amino_acid levels in the rat liver_tumour cells HTC and Phi-1 .
18248830	0	amino_acid	40,50	N-acetylgalactosamine-4-sulfatase	68,101	amino acid	N-acetylgalactosamine-4-sulfatase	CHEBI:33704	411	Chemical	Gene	substitutions|amod|START_ENTITY substitutions|nmod|END_ENTITY	Structural and clinical implications of amino_acid substitutions in N-acetylgalactosamine-4-sulfatase : insight into mucopolysaccharidosis_type_VI .
2077036	0	amino_acid	72,82	N-cadherin	95,105	amino acid	N-cadherin	CHEBI:33704	1000	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Broad spectrum pan-cadherin antibodies , reactive with the C-terminal 24 amino_acid residues of N-cadherin .
3549279	0	amino_acid	84,94	N1/N2	138,143	amino acid	N1/N2	CHEBI:33704	397901(Tax:8355)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Molecular characterization of a karyophilic , histone-binding protein : cDNA cloning , amino_acid sequence and expression of nuclear protein N1/N2 of Xenopus_laevis .
9360996	7	amino_acid	828,838	NAG-2	851,856	amino acid	NAG-2	CHEBI:33704	7106	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	When aligned with other TM4SF proteins , the deduced amino_acid sequence of NAG-2 showed most identity -LRB- 34 % -RRB- to CD53 .
18773084	0	amino_acid	22,32	NAT2	49,53	amino acid	NAT2	CHEBI:33704	10	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Multiple advantageous amino_acid variants in the NAT2 gene in human populations .
9371728	0	amino_acid	85,95	NBAT	109,113	amino acid	NBAT	CHEBI:33704	20532(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|transporter transporter|appos|END_ENTITY	Cloning , functional expression and dietary regulation of the mouse neutral and basic amino_acid transporter -LRB- NBAT -RRB- .
11997120	0	amino_acid	76,86	NBL-1	104,109	amino acid	NBL-1	CHEBI:33704	535280(Tax:9913)	Chemical	Gene	transporter|amod|START_ENTITY transporter|nmod|cells cells|compound|END_ENTITY	Characterisation and cloning of a Na -LRB- + -RRB- - dependent broad-specificity neutral amino_acid transporter from NBL-1 cells : a novel member of the ASC/B -LRB- 0 -RRB- transporter family .
1550853	0	amino_acid	98,108	NBL-1	38,43	amino acid	NBL-1	CHEBI:33704	535280(Tax:9913)	Chemical	Gene	system|amod|START_ENTITY Na|dep|system expresses|dobj|Na expresses|nsubj|END_ENTITY	The bovine renal epithelial cell line NBL-1 expresses a broad specificity Na -LRB- + -RRB- - dependent neutral amino_acid transport system -LRB- System Bo -RRB- similar to that in bovine renal brush border membrane vesicles .
24178682	0	amino_acid	14,24	NBL-1	69,74	amino acid	NBL-1	CHEBI:33704	4681	Chemical	Gene	transport|amod|START_ENTITY Regulation|nmod|transport Regulation|nmod|END_ENTITY	Regulation of amino_acid transport in the renal epithelial cell line NBL-1 .
7954707	0	amino_acid	82,92	NBL-1	73,78	amino acid	NBL-1	CHEBI:33704	535280(Tax:9913)	Chemical	Gene	deprivation|amod|START_ENTITY induced|nmod|deprivation induced|nmod|END_ENTITY	Calreticulin -- a stress protein induced in the renal epithelial cell line NBL-1 by amino_acid deprivation .
26207592	0	amino_acid	11,21	NMB1612	187,194	amino acid	NMB1612	D000596	902102(Tax:122586)	Chemical	Gene	protein|amod|START_ENTITY induces|nsubj|protein induces|nmod|meningococci meningococci|acl|expressing expressing|dobj|proteins proteins|compound|END_ENTITY	A putative amino_acid ABC transporter substrate-binding protein , NMB1612 , from Neisseria_meningitidis , induces murine bactericidal antibodies against meningococci expressing heterologous NMB1612 proteins .
26207592	0	amino_acid	11,21	NMB1612	65,72	amino acid	NMB1612	D000596	902102(Tax:122586)	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	A putative amino_acid ABC transporter substrate-binding protein , NMB1612 , from Neisseria_meningitidis , induces murine bactericidal antibodies against meningococci expressing heterologous NMB1612 proteins .
2062928	0	amino_acid	5,15	NPY	51,54	amino acid	NPY	CHEBI:33704	24604(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Full amino_acid sequence of centrally administered NPY required for maximal food intake response .
9425000	0	amino_acid	18,28	NR2A	45,49	amino acid	NR2A	CHEBI:33704	2903	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Identification of amino_acid residues of the NR2A subunit that control glutamate potency in recombinant NR1/NR2A NMDA receptors .
11293485	0	amino_acid	21,31	NSP4	49,53	amino acid	NSP4	CHEBI:33704	400668	Chemical	Gene	substitutions|amod|START_ENTITY substitutions|nmod|END_ENTITY	A lack of consistent amino_acid substitutions in NSP4 between rotaviruses derived from diarrheal_and_asymptomatically-infected kittens .
10722730	3	amino_acid	434,444	NUDT5	457,462	amino acid	NUDT5	CHEBI:33704	53893(Tax:10090)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The deduced amino_acid sequence of NUDT5 contains 219 amino_acids , including a conserved Nudix box sequence .
4944623	0	amino_acid	51,61	Nerve_growth_factor	0,19	amino acid	Nerve growth factor	CHEBI:33704	18049(Tax:10090)	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|dep|sequence	Nerve_growth_factor from mouse submaxillary gland : amino_acid sequence .
6957876	0	amino_acid	25,35	Neuropeptide_Y	0,14	amino acid	Neuropeptide Y	CHEBI:33704	4852	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|dep|sequence	Neuropeptide_Y : complete amino_acid sequence of the brain peptide .
8575462	0	amino_acid	13,23	Neurothelin	0,11	amino acid	Neurothelin	CHEBI:33704	770363(Tax:9031)	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|dep|sequence	Neurothelin : amino_acid sequence , cell surface dynamics and actin colocalization .
2308822	0	amino_acid	12,22	O6-methylguanine-DNA_methyltransferase	46,84	amino acid	O6-methylguanine-DNA methyltransferase	CHEBI:33704	616091(Tax:9913)	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Active site amino_acid sequence of the bovine O6-methylguanine-DNA_methyltransferase .
12354210	5	amino_acid	632,642	ORF3	659,663	amino acid	ORF3	CHEBI:33704	4924653(Tax:562)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|gene gene|compound|END_ENTITY	The deduced amino_acid sequence of the ORF3 gene had significant similarity to sequences of protoporphyrinogen oxidase -LRB- PPO -RRB- from Myxococcus_xanthus -LRB- 30 % identical residues -RRB- .
17266766	6	amino_acid	881,891	Oct1	916,920	amino acid	Oct1	CHEBI:33704	18986(Tax:10090)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The inferred amino_acid sequence of the catfish Oct1 , when aligned with other vertebrate Oct1 sequences , revealed clear conservation of structure , with the POU specific subdomain of catfish Oct1 showing 96 % identity to that of mouse Oct1 .
2480959	1	amino_acid	179,189	P-450scc	206,214	amino acid	P-450scc	CHEBI:33704	29680(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	cDNA and deduced amino_acid sequence of rat P-450scc .
15521011	0	amino_acid	3,13	PAT1	29,33	amino acid	PAT1	CHEBI:33704	206358	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	H + / amino_acid transporter 1 -LRB- PAT1 -RRB- is the imino_acid carrier : An intestinal nutrient/drug transporter in human and rat .
16373326	0	amino_acid	30,40	PAT1	121,125	amino acid	PAT1	CHEBI:33704	100008971(Tax:9986)	Chemical	Gene	PAT1|amod|START_ENTITY Isolation|nmod|PAT1 Isolation|nmod|transport transport|nmod|IMINO IMINO|compound|END_ENTITY	Isolation and function of the amino_acid transporter PAT1 -LRB- slc36a1 -RRB- from rabbit and discrimination between transport via PAT1 and system IMINO in renal brush-border membrane vesicles .
22234618	0	amino_acid	67,77	PAT1	91,95	amino acid	PAT1	CHEBI:33704	206358	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Rectal absorption of vigabatrin , a substrate of the proton coupled amino_acid transporter -LRB- PAT1 , Slc36a1 -RRB- , in rats .
22574197	0	amino_acid	16,26	PAT1	39,43	amino acid	PAT1	CHEBI:33704	206358	Chemical	Gene	START_ENTITY|dobj|complexes complexes|compound|END_ENTITY	Proton-assisted amino_acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes .
15595847	0	amino_acid	9,19	PCNA	43,47	amino acid	PCNA	CHEBI:33704	5111	Chemical	Gene	change|amod|START_ENTITY change|nmod|END_ENTITY	A single amino_acid change -LRB- E85K -RRB- in human PCNA that leads , relative to wild type , to enhanced DNA synthesis by DNA_polymerase_delta past nucleotide base lesions -LRB- TLS -RRB- as well as on unmodified templates .
1380958	0	amino_acid	12,22	PDGF_B	5,11	amino acid	PDGF B	CHEBI:33704	18591(Tax:10090)	Chemical	Gene	substitutions|amod|START_ENTITY substitutions|compound|END_ENTITY	Five PDGF_B amino_acid substitutions convert PDGF_A to a PDGF_B-like transforming molecule .
7805892	0	amino_acid	17,27	PK-120	46,52	amino acid	PK-120	CHEBI:33704	3700	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	cDNA and deduced amino_acid sequence of human PK-120 , a plasma kallikrein-sensitive glycoprotein .
12659185	0	amino_acid	26,36	PP3	53,56	amino acid	PP3	CHEBI:33704	282430(Tax:9913)	Chemical	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	Distinguishing of Ile/Leu amino_acid residues in the PP3 protein by -LRB- hot -RRB- electron capture dissociation in Fourier transform ion cyclotron resonance mass spectrometry .
9749374	0	amino_acid	38,48	PP3	107,110	amino acid	PP3	CHEBI:33704	282430(Tax:9913)	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	The primary structure of caprine PP3 : amino_acid sequence , phosphorylation , and glycosylation of component PP3 from the proteose-peptone fraction of caprine milk .
9749374	0	amino_acid	38,48	PP3	33,36	amino acid	PP3	CHEBI:33704	282430(Tax:9913)	Chemical	Gene	START_ENTITY|nsubj|structure structure|nmod|END_ENTITY	The primary structure of caprine PP3 : amino_acid sequence , phosphorylation , and glycosylation of component PP3 from the proteose-peptone fraction of caprine milk .
19606831	0	amino_acid	100,110	PSGL-1	124,130	amino acid	PSGL-1	CHEBI:33704	6404	Chemical	Gene	START_ENTITY|acl|derived derived|nmod|END_ENTITY	Rapid assembly of oligosaccharides : a highly convergent strategy for the assembly of a glycosylated amino_acid derived from PSGL-1 .
6033191	0	amino_acid	31,41	Parathyroid_hormone	0,19	amino acid	Parathyroid hormone	CHEBI:33704	5741	Chemical	Gene	transport|amod|START_ENTITY effects|nmod|transport effects|nsubj|END_ENTITY	Parathyroid_hormone effects on amino_acid transport into bone cells .
18272525	0	amino_acid	32,42	Phs1	55,59	amino acid	Phs1	CHEBI:33704	853348(Tax:4932)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Membrane topology and essential amino_acid residues of Phs1 , a 3-hydroxyacyl-CoA dehydratase involved in very long-chain fatty_acid elongation .
25701231	0	amino_acid	86,96	Prolactin	0,9	amino acid	Prolactin	CHEBI:33704	5617	Chemical	Gene	regulate|ccomp|START_ENTITY regulate|nsubj|END_ENTITY	Prolactin and the dietary protein/carbohydrate ratio regulate the expression of SNAT2 amino_acid transporter in the mammary_gland during lactation .
22339635	0	amino_acid	26,36	PsbO	54,58	amino acid	PsbO	CHEBI:33704	5720328(Tax:3055)	Chemical	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	Effect of K223E and K226E amino_acid substitutions in PsbO protein of photosystem 2 on stability and functional activity of the water-oxidizing complex in Chlamydomonas_reinhardtii .
14517252	0	amino_acid	50,60	Put3p	76,81	amino acid	Put3p	CHEBI:33704	853854(Tax:4932)	Chemical	Gene	START_ENTITY|dep|activation activation|nmod|END_ENTITY	Modulation of transcription factor function by an amino_acid : activation of Put3p by proline .
3884090	0	amino_acid	86,96	Pyruvate_carboxylase	0,20	amino acid	Pyruvate carboxylase	CHEBI:33704	5091	Chemical	Gene	pools|amod|START_ENTITY replenishment|nmod|pools implicated|nmod|replenishment enzyme|acl|implicated END_ENTITY|dep|enzyme	Pyruvate_carboxylase : an astrocyte-specific enzyme implicated in the replenishment of amino_acid neurotransmitter pools .
16941217	0	amino_acid	7,17	RCY1	54,58	amino acid	RCY1	CHEBI:33704	817183(Tax:3702)	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	Single amino_acid alterations in Arabidopsis_thaliana RCY1 compromise resistance to Cucumber_mosaic_virus , but differentially suppress hypersensitive response-like cell death .
16400180	0	amino_acid	99,109	RTS1	12,16	amino acid	RTS1	CHEBI:33704	854179(Tax:4932)	Chemical	Gene	START_ENTITY|nsubj|Deletion Deletion|nmod|END_ENTITY	Deletion of RTS1 , encoding a regulatory subunit of protein phosphatase 2A , results in constitutive amino_acid signaling via increased Stp1p processing .
1122277	0	amino_acid	4,14	Ra5	51,54	amino acid	Ra5	CHEBI:33704	474225	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The amino_acid sequence of ragweed pollen allergen Ra5 .
26308575	0	amino_acid	9,19	Rab1A	138,143	amino acid	Rab1A	D000596	5861	Chemical	Gene	START_ENTITY|xcomp|signaling signaling|nmod|END_ENTITY	Aberrant amino_acid signaling promotes growth and metastasis of hepatocellular_carcinomas through Rab1A-dependent activation of mTORC1 by Rab1A .
8016101	0	amino_acid	9,19	Raf-1	30,35	amino acid	Raf-1	CHEBI:33704	397857(Tax:8355)	Chemical	Gene	change|amod|START_ENTITY change|nmod|END_ENTITY	A single amino_acid change in Raf-1 inhibits Ras binding and alters Raf-1 function .
18931342	0	amino_acid	85,95	Rh-associated_glycoprotein	117,143	amino acid	Rh-associated glycoprotein	CHEBI:33704	6005	Chemical	Gene	substitutions|amod|START_ENTITY substitutions|nmod|END_ENTITY	The monovalent cation leak in overhydrated stomatocytic red blood cells results from amino_acid substitutions in the Rh-associated_glycoprotein .
19744193	0	amino_acid	62,72	Rh-associated_glycoprotein	94,120	amino acid	Rh-associated glycoprotein	CHEBI:33704	6005	Chemical	Gene	substitutions|amod|START_ENTITY substitutions|nmod|END_ENTITY	A new blood group system , RHAG : three antigens resulting from amino_acid substitutions in the Rh-associated_glycoprotein .
22719904	5	amino_acid	1233,1243	RyR1	1244,1248	amino acid	RyR1	CHEBI:33704	6261	Chemical	Gene	fragment|compound|START_ENTITY fragment|compound|END_ENTITY	FRET efficiency values measured from each GFP donor to Cy3NTA bound to each His tag acceptor site were converted into intermolecular distances and the positions of each inserted GFP were then triangulated relative to a previously published X-ray crystal structure of a 559 amino_acid RyR1 fragment .
4031854	0	amino_acid	55,65	S100_beta	78,87	amino acid	S100 beta	CHEBI:33704	6285	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Characterization of human brain S100 protein fraction : amino_acid sequence of S100_beta .
11311116	0	amino_acid	75,85	SAT2	69,73	amino acid	SAT2	CHEBI:33704	360547(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|localization localization|appos|END_ENTITY	Subcellular localization and adaptive up-regulation of the System A -LRB- SAT2 -RRB- amino_acid transporter in skeletal-muscle cells and adipocytes .
11716780	0	amino_acid	114,124	SAT2	140,144	amino acid	SAT2	CHEBI:33704	54407	Chemical	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Transforming_growth_factor-beta_1 stimulates vascular smooth muscle cell L-proline transport by inducing system A amino_acid transporter 2 -LRB- SAT2 -RRB- gene expression .
12065289	0	amino_acid	28,38	SLC19A2	78,85	amino acid	SLC19A2	CHEBI:33704	10560	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Functional role of specific amino_acid residues in human thiamine transporter SLC19A2 : mutational analysis .
15296513	0	amino_acid	53,63	SLC1A2	84,90	amino acid	SLC1A2	CHEBI:33704	6506	Chemical	Gene	START_ENTITY|dobj|gene gene|appos|END_ENTITY	Association study of polymorphisms in the excitatory amino_acid transporter 2 gene -LRB- SLC1A2 -RRB- with schizophrenia .
15754324	0	amino_acid	49,59	SLC36A1	79,86	amino acid	SLC36A1	CHEBI:33704	206358	Chemical	Gene	START_ENTITY|dobj|hPAT1 hPAT1|appos|END_ENTITY	Indirect regulation of the intestinal H + - coupled amino_acid transporter hPAT1 -LRB- SLC36A1 -RRB- .
20128809	0	amino_acid	49,59	SLC36A1	72,79	amino acid	SLC36A1	CHEBI:33704	206358	Chemical	Gene	transporter|amod|START_ENTITY substrate|nmod|transporter END_ENTITY|amod|substrate	Delta-aminolevulinic_acid is a substrate for the amino_acid transporter SLC36A1 -LRB- hPAT1 -RRB- .
20880398	0	amino_acid	19,29	SLC36A1	43,50	amino acid	SLC36A1	CHEBI:33704	206358	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	The proton-coupled amino_acid transporter , SLC36A1 -LRB- hPAT1 -RRB- , transports Gly-Gly , Gly-Sar and other Gly-Gly mimetics .
21112392	0	amino_acid	46,56	SLC36A1	72,79	amino acid	SLC36A1	CHEBI:33704	206358	Chemical	Gene	START_ENTITY|dep|transporter transporter|nummod|END_ENTITY	Gaboxadol has affinity for the proton-coupled amino_acid transporter 1 , SLC36A1 -LRB- hPAT1 -RRB- -- A modelling approach to determine IC -LRB- 50 -RRB- values of the three ionic species of gaboxadol .
22853447	0	amino_acid	49,59	SLC36A1	78,85	amino acid	SLC36A1	CHEBI:33704	206358	Chemical	Gene	PAT1|amod|START_ENTITY PAT1|appos|END_ENTITY	Intestinal drug transport via the proton-coupled amino_acid transporter PAT1 -LRB- SLC36A1 -RRB- is inhibited by Gly-X -LRB- aa -RRB- _ dipeptides .
21097500	0	amino_acid	35,45	SLC36A4	0,7	amino acid	SLC36A4	CHEBI:33704	445866(Tax:8355)	Chemical	Gene	transporter|amod|START_ENTITY transporter|nsubj|END_ENTITY	SLC36A4 -LRB- hPAT4 -RRB- is a high affinity amino_acid transporter when expressed in Xenopus_laevis oocytes .
21771784	0	amino_acid	68,78	SLC6A14	0,7	amino acid	SLC6A14	CHEBI:33704	11254	Chemical	Gene	transporter|compound|START_ENTITY protein|appos|transporter protein|amod|END_ENTITY	SLC6A14 -LRB- ATB0 , + -RRB- protein , a highly concentrative and broad specific amino_acid transporter , is a novel and effective drug target for treatment of estrogen_receptor-positive_breast_cancer .
21964291	0	amino_acid	19,29	SLC6A19	42,49	amino acid	SLC6A19	CHEBI:33704	447481(Tax:8355)	Chemical	Gene	transporter|amod|START_ENTITY Stimulation|nmod|transporter END_ENTITY|nsubj|Stimulation	Stimulation of the amino_acid transporter SLC6A19 by JAK2 .
23234856	0	amino_acid	17,27	SLC6A19	40,47	amino acid	SLC6A19	CHEBI:33704	447481(Tax:8355)	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Up-regulation of amino_acid transporter SLC6A19 activity and surface protein abundance by PKB/Akt and PIKfyve .
12464022	0	amino_acid	66,76	SLC7A10	90,97	amino acid	SLC7A10	CHEBI:33704	100056323(Tax:9796)	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Mapping of equine potassium_chloride co-transporter -LRB- SLC12A4 -RRB- and amino_acid transporter -LRB- SLC7A10 -RRB- and preliminary studies on associations between SNPs from SLC12A4 , SLC7A10 and SLC7A9 and osmotic fragility of erythrocytes .
21949876	0	amino_acid	9,19	SNAP-25	32,39	amino acid	SNAP-25	CHEBI:33704	20614(Tax:10090)	Chemical	Gene	mutation|amod|START_ENTITY mutation|nmod|END_ENTITY	A single amino_acid mutation in SNAP-25 induces anxiety-related behavior in mouse .
20599747	0	amino_acid	38,48	SNAT1	20,25	amino acid	SNAT1	CHEBI:33704	81539	Chemical	Gene	activity|amod|START_ENTITY contribution|dep|activity contribution|nmod|END_ENTITY	The contribution of SNAT1 to system A amino_acid transporter activity in human placental trophoblast .
24454923	0	amino_acid	23,33	SNAT1	49,54	amino acid	SNAT1	CHEBI:33704	81539	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Sodium-coupled neutral amino_acid transporter 1 -LRB- SNAT1 -RRB- modulates L-citrulline transport and nitric_oxide -LRB- NO -RRB- signaling in piglet pulmonary arterial endothelial cells .
16445384	0	amino_acid	24,34	SNAT2	118,123	amino acid	SNAT2	CHEBI:33704	54407	Chemical	Gene	element|amod|START_ENTITY Characterization|nmod|element amino_acid|nsubj|Characterization amino_acid|ccomp|System System|nsubj|transporter transporter|appos|END_ENTITY	Characterization of the amino_acid response element within the human sodium-coupled neutral amino_acid transporter 2 -LRB- SNAT2 -RRB- System A transporter gene .
16445384	0	amino_acid	92,102	SNAT2	118,123	amino acid	SNAT2	CHEBI:33704	54407	Chemical	Gene	START_ENTITY|ccomp|System System|nsubj|transporter transporter|appos|END_ENTITY	Characterization of the amino_acid response element within the human sodium-coupled neutral amino_acid transporter 2 -LRB- SNAT2 -RRB- System A transporter gene .
16621798	0	amino_acid	48,58	SNAT2	34,39	amino acid	SNAT2	CHEBI:33704	54407	Chemical	Gene	transporter|amod|START_ENTITY transporter|amod|END_ENTITY	Amino_acid starvation induces the SNAT2 neutral amino_acid transporter by a mechanism that involves eukaryotic initiation factor 2alpha phosphorylation and cap-independent translation .
16629640	0	amino_acid	89,99	SNAT2	61,66	amino acid	SNAT2	CHEBI:33704	54407	Chemical	Gene	START_ENTITY|nsubj|Evidence Evidence|nmod|regulation regulation|nmod|A A|appos|END_ENTITY	Evidence for allosteric regulation of pH-sensitive System A -LRB- SNAT2 -RRB- and System_N -LRB- SNAT5 -RRB- amino_acid transporter activity involving a conserved histidine residue .
16787963	0	amino_acid	58,68	SNAT2	89,94	amino acid	SNAT2	CHEBI:33704	29642(Tax:10116)	Chemical	Gene	A|amod|START_ENTITY expression|nmod|A Characterization|nmod|expression Characterization|appos|END_ENTITY	Characterization and regulation of the gene expression of amino_acid transport system A -LRB- SNAT2 -RRB- in rat mammary gland .
17429052	0	amino_acid	49,59	SNAT2	32,37	amino acid	SNAT2	CHEBI:33704	54407	Chemical	Gene	levels|amod|START_ENTITY determines|dobj|levels determines|nsubj|END_ENTITY	Acidosis-sensing glutamine pump SNAT2 determines amino_acid levels and mammalian_target_of_rapamycin signalling to protein synthesis in L6 muscle cells .
17488712	0	amino_acid	101,111	SNAT2	56,61	amino acid	SNAT2	CHEBI:33704	54407	Chemical	Gene	availability|amod|START_ENTITY pathways|nmod|availability pathways|nmod|control control|nmod|END_ENTITY	Distinct sensor pathways in the hierarchical control of SNAT2 , a putative amino_acid transceptor , by amino_acid availability .
17488712	0	amino_acid	74,84	SNAT2	56,61	amino acid	SNAT2	CHEBI:33704	54407	Chemical	Gene	transceptor|amod|START_ENTITY END_ENTITY|appos|transceptor	Distinct sensor pathways in the hierarchical control of SNAT2 , a putative amino_acid transceptor , by amino_acid availability .
18330498	0	amino_acid	35,45	SNAT2	25,30	amino acid	SNAT2	CHEBI:33704	29642(Tax:10116)	Chemical	Gene	transporter|amod|START_ENTITY END_ENTITY|appos|transporter	Regulatory mechanisms of SNAT2 , an amino_acid transporter , in L6 rat skeletal muscle cells by insulin , osmotic_shock and amino_acid deprivation .
19240036	0	amino_acid	6,16	SNAT2	0,5	amino acid	SNAT2	CHEBI:33704	54407	Chemical	Gene	transporter|amod|START_ENTITY transporter|nummod|END_ENTITY	SNAT2 amino_acid transporter is regulated by amino_acids of the SLC6 gamma-aminobutyric_acid transporter subfamily in neocortical neurons and may play no role in delivering glutamine for glutamatergic transmission .
19589777	0	amino_acid	61,71	SNAT2	87,92	amino acid	SNAT2	CHEBI:33704	54407	Chemical	Gene	START_ENTITY|dobj|2 2|appos|END_ENTITY	A conserved Na -LRB- + -RRB- binding site of the sodium-coupled neutral amino_acid transporter 2 -LRB- SNAT2 -RRB- .
21718781	0	amino_acid	24,34	SNAT2	18,23	amino acid	SNAT2	CHEBI:33704	29642(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of the SNAT2 amino_acid transporter during the development of rat cerebral cortex .
22215663	0	amino_acid	70,80	SNAT2	96,101	amino acid	SNAT2	CHEBI:33704	54407	Chemical	Gene	transporter|amod|START_ENTITY system|dep|transporter system|appos|END_ENTITY	Functional RNA interference -LRB- RNAi -RRB- screen identifies system A neutral amino_acid transporter 2 -LRB- SNAT2 -RRB- as a mediator of arsenic-induced endoplasmic_reticulum_stress .
24434061	0	amino_acid	9,19	SNAT2	32,37	amino acid	SNAT2	CHEBI:33704	29642(Tax:10116)	Chemical	Gene	START_ENTITY|ccomp|shows shows|nsubj|END_ENTITY	System A amino_acid transporter SNAT2 shows subtype-specific affinity for betaine and hyperosmotic inducibility in placental trophoblasts .
25056967	0	amino_acid	57,67	SNAT2	81,86	amino acid	SNAT2	CHEBI:33704	54407	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Transcriptional regulation of the sodium-coupled neutral amino_acid transporter -LRB- SNAT2 -RRB- by 17b-estradiol .
25701231	0	amino_acid	86,96	SNAT2	80,85	amino acid	SNAT2	CHEBI:33704	54407	Chemical	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Prolactin and the dietary protein/carbohydrate ratio regulate the expression of SNAT2 amino_acid transporter in the mammary_gland during lactation .
15899884	0	amino_acid	27,37	SNAT3	50,55	amino acid	SNAT3	CHEBI:33704	76257(Tax:10090)	Chemical	Gene	transporter|amod|START_ENTITY regulation|nmod|transporter END_ENTITY|nsubj|regulation	Differential regulation of amino_acid transporter SNAT3 by insulin in hepatocytes .
16148032	0	amino_acid	26,36	SNAT4	0,5	amino acid	SNAT4	CHEBI:33704	55089	Chemical	Gene	transporter|amod|START_ENTITY system|dep|transporter isoform|nmod|system isoform|compound|END_ENTITY	SNAT4 isoform of system A amino_acid transporter is expressed in human placenta .
19015196	0	amino_acid	34,44	SNAT4	4,9	amino acid	SNAT4	D000596	55089	Chemical	Gene	transporter|amod|START_ENTITY system|dep|transporter isoform|nmod|system isoform|compound|END_ENTITY	The SNAT4 isoform of the system A amino_acid transporter is functional in human placental microvillous plasma membrane .
21917917	0	amino_acid	53,63	SNAT4	79,84	amino acid	SNAT4	CHEBI:33704	55089	Chemical	Gene	START_ENTITY|dobj|protein protein|amod|4 4|dep|END_ENTITY	Membrane topological structure of neutral system N/A amino_acid transporter 4 -LRB- SNAT4 -RRB- protein .
23301202	0	amino_acid	69,79	SNAT4	93,98	amino acid	SNAT4	CHEBI:33704	55089	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Residue cysteine 232 is important for substrate transport of neutral amino_acid transporter , SNAT4 .
23451088	0	amino_acid	87,97	SNAT4	73,78	amino acid	SNAT4	CHEBI:33704	55089	Chemical	Gene	START_ENTITY|nsubj|Identification Identification|nmod|bridge bridge|amod|neutral neutral|advmod|important important|nmod|function function|nmod|END_ENTITY	Identification of a disulfide bridge important for transport function of SNAT4 neutral amino_acid transporter .
16629640	0	amino_acid	89,99	SNAT5	82,87	amino acid	SNAT5	CHEBI:33704	92745	Chemical	Gene	START_ENTITY|nsubj|Evidence Evidence|nmod|regulation regulation|nmod|A A|appos|END_ENTITY	Evidence for allosteric regulation of pH-sensitive System A -LRB- SNAT2 -RRB- and System_N -LRB- SNAT5 -RRB- amino_acid transporter activity involving a conserved histidine residue .
15628884	0	amino_acid	60,70	SP-B	119,123	amino acid	SP-B	CHEBI:33704	6439	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Intrinsic structural and functional determinants within the amino_acid sequence of mature pulmonary surfactant protein SP-B .
1815505	0	amino_acid	22,32	SP-B	80,84	amino acid	SP-B	CHEBI:33704	6439	Chemical	Gene	sequences|compound|START_ENTITY sequences|nmod|END_ENTITY	Identical and similar amino_acid sequences in the pulmonary surfactant proteins SP-B and SP-C and hemerythrin and myohemerythrin -- an example of `` biochemical Velcro '' ?
2706272	0	amino_acid	23,33	SP-C	81,85	amino acid	SP-C	CHEBI:33704	50683(Tax:10116)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Nucleotide and deduced amino_acid sequence of the hydrophobic surfactant protein SP-C from rat : expression in alveolar type II cells and homology with SP-C from other species .
19812301	5	amino_acid	1031,1041	SPAM1	1061,1066	amino acid	SPAM1	CHEBI:33704	353352(Tax:9913)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Two-dimensional electrophoresis revealed that the two isoforms have different masses -LRB- 80 and 70 kDa , respectively -RRB- , and LC/MS/MS analyses confirmed our previously published deduced amino_acid sequence of bovine SPAM1 .
21073748	0	amino_acid	18,28	SRP72	49,54	amino acid	SRP72	CHEBI:33704	6731	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Identification of amino_acid residues in protein SRP72 required for binding to a kinked 5e motif of the human signal recognition particle RNA .
8299963	0	amino_acid	20,30	SV2	43,46	amino acid	SV2	CHEBI:33704	117559(Tax:10116)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Conservation of the amino_acid sequence of SV2 , a transmembrane transporter in synaptic vesicles and endocrine cells .
24345910	0	amino_acid	18,28	Siva-1	39,45	amino acid	Siva-1	CHEBI:33704	10572	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	The N-terminal 33 amino_acid domain of Siva-1 is sufficient for nuclear localization .
22234618	0	amino_acid	67,77	Slc36a1	97,104	amino acid	Slc36a1	CHEBI:33704	155205(Tax:10116)	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|PAT1 PAT1|dep|END_ENTITY	Rectal absorption of vigabatrin , a substrate of the proton coupled amino_acid transporter -LRB- PAT1 , Slc36a1 -RRB- , in rats .
21636576	0	amino_acid	69,79	Slc6a19	95,102	amino acid	Slc6a19	CHEBI:33704	74338(Tax:10090)	Chemical	Gene	cotransporter|amod|START_ENTITY cotransporter|appos|END_ENTITY	Impaired nutrient signaling and body weight control in a Na + neutral amino_acid cotransporter -LRB- Slc6a19 -RRB- - deficient mouse .
18307103	0	amino_acid	76,86	Ssy1	71,75	amino acid	Ssy1	CHEBI:33704	851738(Tax:4932)	Chemical	Gene	START_ENTITY|nsubj|forms forms|nmod|END_ENTITY	Hyper - and hyporesponsive mutant forms of the Saccharomyces_cerevisiae Ssy1 amino_acid sensor .
15947203	0	amino_acid	81,91	Ssy5p	43,48	amino acid	Ssy5p	CHEBI:33704	853285(Tax:4932)	Chemical	Gene	START_ENTITY|nsubj|transduction transduction|nmod|END_ENTITY	Constitutive signal transduction by mutant Ssy5p and Ptr3p components of the SPS amino_acid sensor system in Saccharomyces_cerevisiae .
21127045	0	amino_acid	85,95	Stp1	49,53	amino acid	Stp1	CHEBI:33704	7141	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|END_ENTITY	Differential regulation of transcription factors Stp1 and Stp2 in the Ssy1-Ptr3-Ssy5 amino_acid sensing pathway .
2528451	0	amino_acid	9,19	T-cell_growth_factor_P40	45,69	amino acid	T-cell growth factor P40	CHEBI:33704	16198(Tax:10090)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Complete amino_acid sequence of a new murine T-cell_growth_factor_P40 .
16684541	0	amino_acid	4,14	TOR	25,28	amino acid	TOR	CHEBI:33704	21977(Tax:10090)	Chemical	Gene	sensitive|amod|START_ENTITY END_ENTITY|amod|sensitive	The amino_acid sensitive TOR pathway from yeast to mammals .
24344203	0	amino_acid	29,39	TOR	54,57	amino acid	TOR	CHEBI:33704	6097	Chemical	Gene	uptake|amod|START_ENTITY uptake|nmod|END_ENTITY	Isp7 is a novel regulator of amino_acid uptake in the TOR signaling pathway .
23182766	0	amino_acid	98,108	TSPO	146,150	amino acid	TSPO	CHEBI:33704	100722263	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Control of hypercholesterolemia and atherosclerosis using the cholesterol recognition/interaction amino_acid sequence of the translocator protein TSPO .
22556244	0	amino_acid	38,48	TYRP1	59,64	amino acid	TYRP1	CHEBI:33704	7306	Chemical	Gene	change|amod|START_ENTITY change|nmod|END_ENTITY	Melanesian blond hair is caused by an amino_acid change in TYRP1 .
6119980	0	amino_acid	39,49	Thy-1_antigen	106,119	amino acid	Thy-1 antigen	CHEBI:33704	7070	Chemical	Gene	compositions|amod|START_ENTITY compositions|nmod|END_ENTITY	Biochemical characterization including amino_acid and carbohydrate compositions of canine and human brain Thy-1_antigen .
15720554	0	amino_acid	18,28	TraR	96,100	amino acid	TraR	CHEBI:33704	6382029(Tax:358)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Identification of amino_acid residues of the Agrobacterium_tumefaciens quorum-sensing regulator TraR that are critical for positive control of transcription .
25975612	3	amino_acid	498,508	Trp1	521,525	amino acid	trp1	D000596	851570(Tax:4932)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The deduced amino_acid sequence of Trp1 in S. fibuligera is 43.5 % homologous to that of Komagataella_pastoris .
8432856	0	amino_acid	33,43	Tumor_necrosis_factor	0,21	amino acid	Tumor necrosis factor	CHEBI:33704	103694380	Chemical	Gene	START_ENTITY|nsubj|stimulates stimulates|compound|END_ENTITY	Tumor_necrosis_factor stimulates amino_acid transport in plasma membrane vesicles from rat liver .
9271076	0	amino_acid	11,21	UDP-glucuronosyltransferase	42,69	amino acid	UDP-glucuronosyltransferase	CHEBI:33704	24862(Tax:10116)	Chemical	Gene	residue|amod|START_ENTITY residue|nmod|END_ENTITY	A critical amino_acid residue , asp446 , in UDP-glucuronosyltransferase .
10848606	0	amino_acid	18,28	UNC-86	80,86	amino acid	UNC-86	CHEBI:33704	176157(Tax:6239)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Identification of amino_acid residues in the Caenorhabditis_elegans POU protein UNC-86 that mediate UNC-86-MEC-3-DNA ternary complex formation .
22043315	0	amino_acid	10,20	USP46	32,37	amino acid	USP46	CHEBI:33704	69727(Tax:10090)	Chemical	Gene	residue|compound|START_ENTITY residue|nmod|END_ENTITY	Lysine 92 amino_acid residue of USP46 , a gene associated with ` behavioral despair ' in mice , influences the deubiquitinating enzyme activity .
1706548	0	amino_acid	4,14	VP2	50,53	amino acid	VP2	CHEBI:33704	2943152(Tax:40051)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The amino_acid sequence of the outer coat_protein VP2 of neutralizing monoclonal antibody-resistant , virulent and attenuated_bluetongue_viruses .
8442657	4	amino_acid	804,814	VPF	800,803	amino acid	VPF	CHEBI:33704	7422	Chemical	Gene	sequence|amod|START_ENTITY sequence|compound|END_ENTITY	Antibodies were raised against a series of synthetic peptides derived from the predicted human VPF amino_acid sequence .
18603011	0	amino_acid	18,28	Vif	47,50	amino acid	Vif	CHEBI:33704	155459(Tax:11676)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Identification of amino_acid residues in HIV-1 Vif critical for binding and exclusion of APOBEC3G/F .
24971727	0	amino_acid	70,80	VirB2	64,69	amino acid	VirB2	CHEBI:33704	1224319(Tax:358)	Chemical	Gene	START_ENTITY|nsubj|characterization characterization|nmod|END_ENTITY	Expression and functional characterization of the Agrobacterium VirB2 amino_acid substitution variants in T-pilus biogenesis , virulence , and transient transformation efficiency .
20815824	0	amino_acid	11,21	YadA	71,75	amino acid	YadA	CHEBI:33704	1449501(Tax:630)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	C-terminal amino_acid residues of the trimeric autotransporter adhesin YadA of Yersinia_enterocolitica are decisive for its recognition and assembly by BamA .
3422450	0	amino_acid	9,19	Zn-alpha_2-glycoprotein	45,68	amino acid	Zn-alpha 2-glycoprotein	CHEBI:33704	563	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Complete amino_acid sequence of human plasma Zn-alpha_2-glycoprotein and its homology to histocompatibility antigens .
10682835	0	amino_acid	13,23	acetoacetyl-CoA_synthetase	36,62	amino acid	acetoacetyl-CoA synthetase	CHEBI:33704	65984(Tax:10116)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	cDNA-derived amino_acid sequence of acetoacetyl-CoA_synthetase from rat liver .
15373811	0	amino_acid	4,14	acetylcholinesterase	32,52	amino acid	acetylcholinesterase	CHEBI:33704	41625(Tax:7227)	Chemical	Gene	substitutions|amod|START_ENTITY substitutions|nmod|END_ENTITY	Two amino_acid substitutions in acetylcholinesterase associated with pirimicarb and organophosphorous insecticide resistance in the cotton aphid , Aphis gossypii Glover -LRB- Homoptera : Aphididae -RRB- .
4071057	0	amino_acid	56,66	acidic_fibroblast_growth_factor	14,45	amino acid	acidic fibroblast growth factor	CHEBI:33704	2246	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|dep|sequence	Brain-derived acidic_fibroblast_growth_factor : complete amino_acid sequence and homologies .
7007202	0	amino_acid	11,21	acrosin	45,52	amino acid	acrosin	CHEBI:33704	49	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	N-Terminal amino_acid sequence of boar sperm acrosin .
588555	0	amino_acid	8,18	actin	37,42	amino acid	actin	CHEBI:33704	528168(Tax:9913)	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Partial amino_acid sequence of brain actin and its homology with muscle actin .
1998686	0	amino_acid	8,18	adenosine_deaminase	48,67	amino acid	adenosine deaminase	CHEBI:33704	100	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Deduced amino_acid sequence of Escherichia_coli adenosine_deaminase reveals evolutionarily conserved amino_acid residues : implications for catalytic function .
7798168	0	amino_acid	46,56	alanine-glyoxylate_transaminase_1	70,103	amino acid	alanine-glyoxylate transaminase 1	CHEBI:33704	189	Chemical	Gene	START_ENTITY|dobj|sequences sequences|nmod|END_ENTITY	Purification and amino - and carboxyl-terminal amino_acid sequences of alanine-glyoxylate_transaminase_1 from human liver .
2881847	0	amino_acid	9,19	alcohol_dehydrogenase	42,63	amino acid	alcohol dehydrogenase	CHEBI:33704	78959(Tax:10116)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Complete amino_acid sequence of rat liver alcohol_dehydrogenase deduced from the cDNA sequence .
8359016	0	amino_acid	157,167	alpha-chain	184,195	amino acid	alpha-chain	CHEBI:33704	2217	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	PCR amplification of partial mRNA sequences encoding the alpha - and beta-globin chains of the bivalve mollusc Anadara trapezia : correction of the C-terminal amino_acid sequence of the alpha-chain .
6038502	0	amino_acid	18,28	alpha-lactalbumin	48,65	amino acid	alpha-lactalbumin	CHEBI:33704	281894(Tax:9913)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Comparison of the amino_acid sequence of bovine alpha-lactalbumin and hens egg white lysozyme .
6525193	0	amino_acid	4,14	alpha-lactalbumin	34,51	amino acid	alpha-lactalbumin	CHEBI:33704	281894(Tax:9913)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The amino_acid sequence of equine alpha-lactalbumin .
6715332	1	amino_acid	46,56	alpha-lactalbumin	73,90	amino acid	alpha-lactalbumin	CHEBI:33704	281894(Tax:9913)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The complete amino_acid sequence of the alpha-lactalbumin from a marsupial -LRB- Macropus rufogriseus -RRB- and corrections to regions of sequence in bovine and goat alpha-lactalbumins .
7019911	0	amino_acid	9,19	alpha-tubulin	32,45	amino acid	alpha-tubulin	CHEBI:33704	10376	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Complete amino_acid sequence of alpha-tubulin from porcine brain .
1346134	0	amino_acid	67,77	alpha_1B-adrenergic_receptor	31,59	amino acid	alpha 1B-adrenergic receptor	CHEBI:33704	147	Chemical	Gene	START_ENTITY|nsubj|activation activation|nmod|END_ENTITY	Constitutive activation of the alpha_1B-adrenergic_receptor by all amino_acid substitutions at a single site .
10862968	0	amino_acid	12,22	aminopeptidase	75,89	amino acid	aminopeptidase	CHEBI:33704	10404	Chemical	Gene	residues|amod|START_ENTITY role|nmod|residues END_ENTITY|nsubj|role	The role of amino_acid residues in the active site of a midgut microvillar aminopeptidase from the beetle Tenebrio molitor .
18701491	0	amino_acid	70,80	aminopeptidase	31,45	amino acid	aminopeptidase	CHEBI:33704	10404	Chemical	Gene	leads|xcomp|START_ENTITY inhibitor|acl:relcl|leads inhibitor|compound|END_ENTITY	CHR-2797 : an antiproliferative aminopeptidase inhibitor that leads to amino_acid deprivation in human leukemic cells .
20510678	0	amino_acid	19,29	aminopeptidase	165,179	amino acid	aminopeptidase	CHEBI:33704	10404	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Impact of system L amino_acid transporter 1 -LRB- LAT1 -RRB- on proliferation of human ovarian_cancer cells : a possible target for combination therapy with anti-proliferative aminopeptidase inhibitors .
6854330	0	amino_acid	74,84	aminopeptidase	3,17	amino acid	aminopeptidase	CHEBI:33704	397520(Tax:9823)	Chemical	Gene	residues|amod|START_ENTITY N-terminal|dobj|residues cytosol|ccomp|N-terminal cytosol|nsubj|END_ENTITY	An aminopeptidase from mouse brain cytosol that cleaves N-terminal acidic amino_acid residues .
7085655	0	amino_acid	40,50	aminopeptidase	22,36	amino acid	aminopeptidase	CHEBI:33704	10404	Chemical	Gene	hydroxamates|amod|START_ENTITY END_ENTITY|nmod|hydroxamates	Inhibition of leucine aminopeptidase by amino_acid hydroxamates .
2901990	0	amino_acid	9,19	aminopeptidase_N	49,65	amino acid	aminopeptidase N	CHEBI:33704	5850654(Tax:562)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Complete amino_acid sequence of human intestinal aminopeptidase_N as deduced from cloned cDNA .
309768	0	amino_acid	36,46	anaphylatoxin	63,76	amino acid	anaphylatoxin	CHEBI:33704	362119(Tax:10116)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Purification , characterization , and amino_acid sequence of rat anaphylatoxin -LRB- C3a -RRB- .
11380707	0	amino_acid	6,16	androgen_receptor	77,94	amino acid	androgen receptor	CHEBI:33704	367	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Novel amino_acid substitutional mutation , tyrosine-739-aspartic_acid , in the androgen_receptor gene in complete androgen insensitivity_syndrome .
12242031	0	amino_acid	83,93	androgen_receptor	110,127	amino acid	androgen receptor	CHEBI:33704	367	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Virilization of the female spotted hyena can not be explained by alterations in the amino_acid sequence of the androgen_receptor -LRB- AR -RRB- .
1856263	0	amino_acid	75,85	androgen_receptor	54,71	amino acid	androgen receptor	CHEBI:33704	367	Chemical	Gene	results|amod|START_ENTITY END_ENTITY|nmod|results	Androgen resistance associated with a mutation of the androgen_receptor at amino_acid 772 -LRB- Arg -- Cys -RRB- results from a combination of decreased messenger ribonucleic_acid levels and impairment_of_receptor_function .
14761188	0	amino_acid	77,87	angiotensin_II	104,118	amino acid	angiotensin II	CHEBI:33704	24179(Tax:10116)	Chemical	Gene	4-5|amod|START_ENTITY 4-5|nmod|END_ENTITY	A selective AT2 receptor ligand with a gamma-turn-like mimetic replacing the amino_acid residues 4-5 of angiotensin_II .
15943474	0	amino_acid	83,93	angiotensin_II	110,124	amino acid	angiotensin II	CHEBI:33704	24179(Tax:10116)	Chemical	Gene	4-5|amod|START_ENTITY 4-5|nmod|END_ENTITY	New selective AT2 receptor ligands encompassing a gamma-turn mimetic replacing the amino_acid residues 4-5 of angiotensin_II act as agonists .
18182243	0	amino_acid	93,103	angiotensin_II	25,39	amino acid	angiotensin II	CHEBI:33704	24179(Tax:10116)	Chemical	Gene	TOAC|amod|START_ENTITY containing|dobj|TOAC analogues|xcomp|containing analogues|nsubj|assessment assessment|nmod|END_ENTITY	Functional assessment of angiotensin_II and bradykinin analogues containing the paramagnetic amino_acid TOAC .
3436303	0	amino_acid	34,44	angiotensin_II	64,78	amino acid	angiotensin II	CHEBI:33704	183	Chemical	Gene	START_ENTITY|nmod|the the|nmod|END_ENTITY	Tyrosine in position 4 is the key amino_acid for the binding of angiotensin_II to human arteriolar receptor .
7635535	0	amino_acid	24,34	angiotensin_II	55,69	amino acid	angiotensin II	CHEBI:33704	24179(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|levels levels|compound|END_ENTITY	Altered angiotensinogen amino_acid sequence and plasma angiotensin_II levels in genetically hypertensive rats .
8712205	0	amino_acid	50,60	angiotensin_II	10,24	amino acid	angiotensin II	CHEBI:33704	24179(Tax:10116)	Chemical	Gene	Effect|acl|START_ENTITY Effect|nmod|END_ENTITY	Effect of angiotensin_II on the renal response to amino_acid in rats .
8723030	0	amino_acid	98,108	angiotensin_II	21,35	amino acid	angiotensin II	CHEBI:33704	183	Chemical	Gene	transport|amod|START_ENTITY regulation|nmod|transport cyclic_monophosphate|nmod|regulation Interactions|dep|cyclic_monophosphate Interactions|nmod|END_ENTITY	Interactions between angiotensin_II and adenosine_3 ' :5 ' - cyclic_monophosphate in the regulation of amino_acid transport by vascular smooth muscle cells .
1838311	0	amino_acid	25,35	annexin_V	48,57	amino acid	annexin V	CHEBI:33704	308	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Purification and partial amino_acid sequence of annexin_V from porcine gastric mucosal membranes .
8742060	0	amino_acid	19,29	anti-neoplastic_urinary_protein	46,77	amino acid	anti-neoplastic urinary protein	CHEBI:33704	57152	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Partial N-terminal amino_acid sequence of the anti-neoplastic_urinary_protein -LRB- ANUP -RRB- and the anti-tumour effect of the N-terminal nonapeptide of the unique cytokine present in human granulocytes .
15935830	0	amino_acid	26,36	antithrombin	130,142	amino acid	antithrombin	CHEBI:33704	462	Chemical	Gene	START_ENTITY|nmod|deficiency deficiency|compound|END_ENTITY	Identification of a novel amino_acid deletion mutation and a very rare single nucleotide variant in a Japanese family with type I antithrombin deficiency .
1930634	0	amino_acid	13,23	antithrombin	43,55	amino acid	antithrombin	CHEBI:33704	462	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The complete amino_acid sequence of bovine antithrombin -LRB- ATIII -RRB- .
2722864	0	amino_acid	8,18	antithrombin	77,89	amino acid	antithrombin	CHEBI:33704	462	Chemical	Gene	START_ENTITY|nmod|site site|nmod|END_ENTITY	A novel amino_acid substitution in the reactive site of a congenital variant antithrombin .
3162733	0	amino_acid	7,17	antithrombin	56,68	amino acid	antithrombin	CHEBI:33704	462	Chemical	Gene	START_ENTITY|nmod|site site|nmod|END_ENTITY	Single amino_acid substitutions in the reactive site of antithrombin leading to thrombosis .
8288594	0	amino_acid	24,34	antithrombin	104,116	amino acid	antithrombin	CHEBI:33704	462	Chemical	Gene	residues|amod|START_ENTITY Identification|nmod|residues essential|nsubj|Identification essential|nmod|III III|compound|END_ENTITY	Identification of basic amino_acid residues in thrombin essential for heparin-catalyzed inactivation by antithrombin III .
11744719	2	amino_acid	320,330	apoA-I	343,349	amino acid	apoA-I	CHEBI:33704	335	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Human apoA-I transgenic_mice exhibit a human-like HDL profile , indicating that the amino_acid sequence of apoA-I is a determinant of the HDL profile .
6653779	0	amino_acid	4,14	apoferritin	39,50	amino acid	apoferritin	CHEBI:33704	2495	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The amino_acid sequence of human liver apoferritin .
1370364	0	amino_acid	4,14	apolipoprotein_B	32,48	amino acid	apolipoprotein B	CHEBI:33704	338	Chemical	Gene	substitutions|amod|START_ENTITY substitutions|nmod|END_ENTITY	Two amino_acid substitutions in apolipoprotein_B are in complete allelic association with the antigen group -LRB- x/y -RRB- polymorphism : evidence for little recombination in the 3 ' end of the human gene .
6373369	0	amino_acid	32,42	apolipoprotein_B	6,22	amino acid	apolipoprotein B	CHEBI:33704	338	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|dep|sequence	Human apolipoprotein_B : partial amino_acid sequence .
11890689	0	amino_acid	29,39	apolipoprotein_B100	55,74	amino acid	apolipoprotein B100	CHEBI:33704	338	Chemical	Gene	composition|amod|START_ENTITY composition|nmod|END_ENTITY	Smoking has no effect on the amino_acid composition of apolipoprotein_B100 of LDL while directly influencing the antioxidant status .
12206678	0	amino_acid	10,20	apolipoprotein_B100	33,52	amino acid	apolipoprotein B100	CHEBI:33704	338	Chemical	Gene	radicals|amod|START_ENTITY Repair|nmod|radicals Repair|nmod|END_ENTITY	Repair of amino_acid radicals of apolipoprotein_B100 of low-density lipoproteins by flavonoids .
18725409	0	amino_acid	8,18	apolipoprotein_B100	46,65	amino acid	apolipoprotein B100	CHEBI:33704	338	Chemical	Gene	START_ENTITY|ccomp|critical critical|nsubj|residues residues|nmod|END_ENTITY	Charged amino_acid residues 997-1000 of human apolipoprotein_B100 are critical for the initiation of lipoprotein assembly and the formation of a stable lipidated primordial particle in McA-RH7777 cells .
1968043	0	amino_acid	96,106	arylsulfatases_A_and_C	121,143	amino acid	arylsulfatases A and C	CHEBI:33704	410;412	Chemical	Gene	identity|amod|START_ENTITY identity|nmod|END_ENTITY	Human arylsulfatase_B : MOPAC cloning , nucleotide sequence of a full-length cDNA , and regions of amino_acid identity with arylsulfatases_A_and_C .
24521937	0	amino_acid	25,35	asparagine_synthetase	115,136	amino acid	asparagine synthetase	CHEBI:33704	100316876(Tax:4081)	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|dep|role role|nmod|END_ENTITY	Modulating plant primary amino_acid metabolism as a necrotrophic virulence strategy : the immune-regulatory role of asparagine_synthetase in Botrytis_cinerea-tomato interaction .
16233295	0	amino_acid	17,27	aspartate_aminotransferase	79,105	amino acid	aspartate aminotransferase	CHEBI:33704	547792(Tax:3847)	Chemical	Gene	content|amod|START_ENTITY Variation|nmod|content END_ENTITY|nsubj|Variation	Variation of the amino_acid content of Arabidopsis seeds by expressing soybean aspartate_aminotransferase gene .
21676488	0	amino_acid	72,82	aspartate_aminotransferase	42,68	amino acid	aspartate aminotransferase	CHEBI:33704	816758(Tax:3702)	Chemical	Gene	metabolism|amod|START_ENTITY END_ENTITY|nmod|metabolism	Influence of over-expression of cytosolic aspartate_aminotransferase on amino_acid metabolism and defence responses against Botrytis_cinerea infection in Arabidopsis_thaliana .
16774919	0	amino_acid	67,77	aspartyl-tRNA_synthetase	125,149	amino acid	aspartyl-tRNA synthetase	CHEBI:33704	1615	Chemical	Gene	START_ENTITY|dobj|specificity specificity|nmod|END_ENTITY	Molecular dynamics simulations show that bound Mg2 + contributes to amino_acid and aminoacyl_adenylate binding specificity in aspartyl-tRNA_synthetase through long range electrostatic interactions .
9480772	0	amino_acid	9,19	aspartyl-tRNA_synthetase	35,59	amino acid	aspartyl-tRNA synthetase	CHEBI:33704	1615	Chemical	Gene	recognition|amod|START_ENTITY recognition|nmod|END_ENTITY	Specific amino_acid recognition by aspartyl-tRNA_synthetase studied by free energy simulations .
221916	4	amino_acid	896,906	beta-LPH	925,933	amino acid	beta-LPH	CHEBI:33704	5443	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Based on assignment of the amino_acid sequence of mouse beta-LPH from the nucelic acid sequence , it appears that there is extensive homology of mouse beta-LPH with human and porcine beta-LPH .
9668120	0	amino_acid	8,18	beta-amyloid_precursor_protein	60,90	amino acid	beta-amyloid precursor protein	CHEBI:33704	351	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	A basic amino_acid in the cytoplasmic domain of Alzheimer 's beta-amyloid_precursor_protein -LRB- APP -RRB- is essential for cleavage of APP at the alpha-site .
8058842	0	amino_acid	11,21	beta-galactosidase	50,68	amino acid	beta-galactosidase	CHEBI:33704	2720	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	N-terminal amino_acid sequence of persimmon fruit beta-galactosidase .
2009291	0	amino_acid	13,23	beta-lactoglobulin_II	43,64	amino acid	beta-lactoglobulin II	CHEBI:33704	100034194(Tax:9796)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The complete amino_acid sequence of feline beta-lactoglobulin_II and a partial revision of the equine beta-lactoglobulin_II sequence .
10379944	0	amino_acid	13,23	beta2-microglobulin	40,59	amino acid	beta2-microglobulin	CHEBI:33704	478284(Tax:9615)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The complete amino_acid sequence of dog beta2-microglobulin .
46618	0	amino_acid	8,18	beta2-microglobulin	38,57	amino acid	beta2-microglobulin	CHEBI:33704	100350679(Tax:9986)	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Partial amino_acid sequence of rabbit beta2-microglobulin .
1650181	0	amino_acid	32,42	beta_2-glycoprotein_I	61,82	amino acid	beta 2-glycoprotein I	CHEBI:33704	5699	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Complete nucleotide and deduced amino_acid sequence of human beta_2-glycoprotein_I .
3277263	0	amino_acid	13,23	beta_2-microglobulin	40,60	amino acid	beta 2-microglobulin	CHEBI:33704	24223(Tax:10116)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The complete amino_acid sequence of rat beta_2-microglobulin .
6165997	0	amino_acid	9,19	beta_2-microglobulin	39,59	amino acid	beta 2-microglobulin	CHEBI:33704	12010(Tax:10090)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Complete amino_acid sequence of murine beta_2-microglobulin : structural evidence for strain-related polymorphism .
6174509	0	amino_acid	9,19	beta_2-microglobulin	39,59	amino acid	beta 2-microglobulin	CHEBI:33704	783680(Tax:9913)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Complete amino_acid sequence of bovine beta_2-microglobulin .
2040616	0	amino_acid	9,19	beta_subunit	44,56	amino acid	beta subunit	CHEBI:33704	10242	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Complete amino_acid sequence of an integrin beta_subunit -LRB- beta 7 -RRB- identified in leukocytes .
8280170	0	amino_acid	9,19	biliverdin-IX_beta_reductase	32,60	amino acid	biliverdin-IX beta reductase	CHEBI:33704	645	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Complete amino_acid sequence of biliverdin-IX_beta_reductase from human liver .
3117099	0	amino_acid	36,46	bleomycin_hydrolase	79,98	amino acid	bleomycin hydrolase	CHEBI:33704	100009580(Tax:9986)	Chemical	Gene	composition|amod|START_ENTITY composition|nmod|END_ENTITY	Purification , characterization , and amino_acid composition of rabbit pulmonary bleomycin_hydrolase .
15102928	0	amino_acid	65,75	bombesin_receptor_subtype_3	146,173	amino acid	bombesin receptor subtype 3	CHEBI:33704	680	Chemical	Gene	substitutions|amod|START_ENTITY substitutions|nmod|END_ENTITY	Development of bombesin analogs with conformationally restricted amino_acid substitutions with enhanced selectivity for the orphan receptor human bombesin_receptor_subtype_3 .
6574479	0	amino_acid	60,70	c-fos	93,98	amino acid	c-fos	CHEBI:33704	2353	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|protein protein|amod|END_ENTITY	Complete nucleotide sequence of a human c-onc gene : deduced amino_acid sequence of the human c-fos protein .
7478514	0	amino_acid	26,36	c-myc	64,69	amino acid	c-myc	CHEBI:33704	24577(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|domain domain|amod|END_ENTITY	Mouse and rat B-myc share amino_acid sequence homology with the c-myc transcriptional activator domain and contain a B-myc specific carboxy terminal region .
2843757	0	amino_acid	60,70	calbindin_D28	93,106	amino acid	Calbindin D28	CHEBI:33704	396519(Tax:9031)	Chemical	Gene	homology|amod|START_ENTITY homology|nmod|END_ENTITY	Rat brain calbindin_D28 : six domain structure and extensive amino_acid homology with chicken calbindin_D28 .
20552635	0	amino_acid	20,30	calcineurin_B	46,59	amino acid	calcineurin B	CHEBI:33704	5534	Chemical	Gene	residue|amod|START_ENTITY residue|nmod|END_ENTITY	The polarity of the amino_acid residue 118 of calcineurin_B is closely linked to calcineurin enzyme activity .
11328610	0	amino_acid	19,29	calcineurin_b	42,55	amino acid	calcineurin b	CHEBI:33704	5534	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	A cluster of basic amino_acid residues in calcineurin_b participates in the binding of calcineurin to phosphatidylserine vesicles .
476518	0	amino_acid	4,14	calcium-binding_protein	46,69	amino acid	calcium-binding protein	CHEBI:33704	397265(Tax:9823)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The amino_acid sequence of porcine intestinal calcium-binding_protein .
20666542	0	amino_acid	35,45	carbonic_anhydrase_II	97,118	amino acid	carbonic anhydrase II	CHEBI:33704	760	Chemical	Gene	START_ENTITY|nmod|mechanism mechanism|nmod|END_ENTITY	Role of second coordination sphere amino_acid residues on the proton transfer mechanism of human carbonic_anhydrase_II -LRB- HCA_II -RRB- .
3951483	0	amino_acid	4,14	cardiac_troponin-C	33,51	amino acid	cardiac troponin-C	CHEBI:33704	7134	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The amino_acid sequence of human cardiac_troponin-C .
2286376	0	amino_acid	9,19	cartilage_link_protein	38,60	amino acid	cartilage link protein	CHEBI:33704	1404	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Complete amino_acid sequence of human cartilage_link_protein -LRB- CRTL1 -RRB- deduced from cDNA clones and chromosomal assignment of the gene .
3459154	0	amino_acid	9,19	cartilage_link_protein	40,62	amino acid	cartilage link protein	CHEBI:33704	396475(Tax:9031)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Complete amino_acid sequence of chicken cartilage_link_protein deduced from cDNA clones .
1028203	0	amino_acid	60,70	catalase	86,94	amino acid	catalase	CHEBI:33704	847	Chemical	Gene	composition|amod|START_ENTITY composition|nmod|END_ENTITY	Radiation damage of proteins in the solid state : changes of amino_acid composition in catalase .
10524763	0	amino_acid	17,27	catalase	45,53	amino acid	catalase	CHEBI:33704	403474(Tax:9615)	Chemical	Gene	START_ENTITY|dobj|sequences sequences|nmod|END_ENTITY	cDNA and deduced amino_acid sequences of dog catalase .
3446581	0	amino_acid	61,71	catalase	96,104	amino acid	catalase	CHEBI:33704	531682(Tax:9913)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The nucleotide sequence of complementary DNA and the deduced amino_acid sequence of peroxisomal catalase of the yeast Candida_tropicalis pK233 .
3455767	0	amino_acid	49,59	catalase	82,90	amino acid	catalase	CHEBI:33704	24248(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Complete nucleotide sequence of cDNA and deduced amino_acid sequence of rat liver catalase .
8360921	0	amino_acid	45,55	catalase	68,76	amino acid	catalase	CHEBI:33704	847	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Molecular evolutionary analysis based on the amino_acid sequence of catalase .
24088021	0	amino_acid	18,28	cathepsin_K	77,88	amino acid	cathepsin K	CHEBI:33704	1513	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	The role of basic amino_acid surface clusters on the collagenase activity of cathepsin_K .
2044774	0	amino_acid	13,23	cathepsin_L	88,99	amino acid	cathepsin L	CHEBI:33704	515200(Tax:9913)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The complete amino_acid sequence of bovine cathepsin_S and a partial sequence of bovine cathepsin_L .
2044774	0	amino_acid	13,23	cathepsin_S	43,54	amino acid	cathepsin S	CHEBI:33704	327711(Tax:9913)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The complete amino_acid sequence of bovine cathepsin_S and a partial sequence of bovine cathepsin_L .
1174289	0	amino_acid	62,72	cholecystokinin	35,50	amino acid	cholecystokinin	CHEBI:33704	885	Chemical	Gene	perfusion|amod|START_ENTITY END_ENTITY|nmod|perfusion	Mechanism of release of endogenous cholecystokinin by jejunal amino_acid perfusion in man .
2103898	0	amino_acid	15,25	cholecystokinin	50,65	amino acid	cholecystokinin	CHEBI:33704	609547(Tax:9615)	Chemical	Gene	infusions|amod|START_ENTITY Composition|nmod|infusions Composition|nmod|END_ENTITY	Composition of amino_acid infusions and effect of cholecystokinin on insulin release in dogs .
6156709	0	amino_acid	22,32	cholecystokinin	51,66	amino acid	cholecystokinin	CHEBI:33704	100735029	Chemical	Gene	importance|nmod|START_ENTITY importance|nmod|END_ENTITY	The importance of the amino_acid in position 27 of cholecystokinin in determining its biological activity on pancreatic acini .
6172156	0	amino_acid	22,32	cholecystokinin	103,118	amino acid	cholecystokinin	CHEBI:33704	885	Chemical	Gene	importance|nmod|START_ENTITY importance|acl|determining determining|nmod|receptors receptors|compound|END_ENTITY	The importance of the amino_acid in position 32 of cholecystokinin in determining its interaction with cholecystokinin receptors on pancreatic acini .
6172156	0	amino_acid	22,32	cholecystokinin	51,66	amino acid	cholecystokinin	CHEBI:33704	885	Chemical	Gene	importance|nmod|START_ENTITY importance|nmod|END_ENTITY	The importance of the amino_acid in position 32 of cholecystokinin in determining its interaction with cholecystokinin receptors on pancreatic acini .
7134033	0	amino_acid	61,71	cholecystokinin	36,51	amino acid	cholecystokinin	CHEBI:33704	885	Chemical	Gene	sequence|amod|START_ENTITY structure|dep|sequence structure|nmod|END_ENTITY	Partial structure of a large canine cholecystokinin -LRB- CCK58 -RRB- : amino_acid sequence .
9404730	0	amino_acid	110,120	cholecystokinin	55,70	amino acid	cholecystokinin	CHEBI:33704	101096837	Chemical	Gene	related|xcomp|START_ENTITY related|nsubjpass|potency potency|nmod|amino_acids amino_acids|acl|elevating elevating|dobj|END_ENTITY	The potency of dietary amino_acids in elevating plasma cholecystokinin immunoreactivity in cats is related to amino_acid hydrophobicity .
1350945	0	amino_acid	23,33	chromogranin_B	69,83	amino acid	chromogranin B	CHEBI:33704	281071(Tax:9913)	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Nucleotide and deduced amino_acid sequence of bovine adrenal medulla chromogranin_B -LRB- secretogranin_I -RRB- .
291916	0	amino_acid	14,24	coagulation_Factor_IX	44,65	amino acid	coagulation Factor IX	CHEBI:33704	280688(Tax:9913)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Comparison of amino_acid sequence of bovine coagulation_Factor_IX -LRB- Christmas_Factor -RRB- with that of other vitamin_K-dependent plasma proteins .
20573010	0	amino_acid	9,19	coat_protein	34,46	amino acid	coat protein	CHEBI:33704	64083	Chemical	Gene	change|amod|START_ENTITY change|nmod|END_ENTITY	A single amino_acid change in the coat_protein of Maize_streak_virus abolishes systemic_infection , but not interaction with viral DNA or movement protein .
26948262	0	amino_acid	18,28	coat_protein	45,57	amino acid	coat protein	D000596	64083	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Identification of amino_acid residues of the coat_protein of Sri_Lankan_cassava_mosaic_virus affecting symptom production and viral titer in Nicotiana benthamiana .
9499805	0	amino_acid	19,29	coat_protein	37,49	amino acid	coat protein	CHEBI:33704	64083	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	A single conserved amino_acid in the coat_protein gene of pea_seed-borne_mosaic_potyvirus modulates the ability of the virus to move systemically in Chenopodium quinoa .
3005321	0	amino_acid	25,35	collagenase_inhibitor	75,96	amino acid	collagenase inhibitor	CHEBI:33704	282093(Tax:9913)	Chemical	Gene	sequence|compound|START_ENTITY sequence|nmod|END_ENTITY	Purification and partial amino_acid sequence of a bovine cartilage-derived collagenase_inhibitor .
3925458	0	amino_acid	15,25	colony-stimulating_factor_1	45,72	amino acid	colony-stimulating factor 1	CHEBI:33704	12977(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Amino-terminal amino_acid sequence of murine colony-stimulating_factor_1 .
2954545	0	amino_acid	28,38	complement_control_protein_factor_I	57,92	amino acid	complement control protein factor I	CHEBI:33704	3426	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Characterization of primary amino_acid sequence of human complement_control_protein_factor_I from an analysis of cDNA clones .
6198962	0	amino_acid	13,23	complex-forming_glycoprotein_heterogeneous_in_charge	42,94	amino acid	complex-forming glycoprotein heterogeneous in charge	CHEBI:33704	259	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The complete amino_acid sequence of human complex-forming_glycoprotein_heterogeneous_in_charge -LRB- protein_HC -RRB- from one individual .
3929689	0	amino_acid	9,19	copper-zinc_superoxide_dismutase	32,64	amino acid	copper-zinc superoxide dismutase	CHEBI:33704	39251(Tax:7227)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Complete amino_acid sequence of copper-zinc_superoxide_dismutase from Drosophila_melanogaster .
7535880	0	amino_acid	27,37	cysteine_string_protein	56,79	amino acid	cysteine string protein	CHEBI:33704	79130(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	The nucleotide and deduced amino_acid sequence of a rat cysteine_string_protein .
7987009	0	amino_acid	23,33	cysteinyl-tRNA_synthetase	52,77	amino acid	cysteinyl-tRNA synthetase	CHEBI:33704	833	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Nucleotide and deduced amino_acid sequence of human cysteinyl-tRNA_synthetase .
2001406	0	amino_acid	17,27	cytochrome_P-450	53,69	amino acid	cytochrome P-450	CHEBI:33704	487648(Tax:9615)	Chemical	Gene	START_ENTITY|dobj|sequences sequences|nmod|END_ENTITY	cDNA and deduced amino_acid sequences of a dog liver cytochrome_P-450 of the IIIA gene subfamily .
3495238	0	amino_acid	9,19	cytochrome_P-450	47,63	amino acid	cytochrome P-450	CHEBI:33704	397687(Tax:9823)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Complete amino_acid sequence of 21-hydroxylase cytochrome_P-450 from porcine adrenal microsomes .
3949797	0	amino_acid	9,19	cytochrome_P-450	34,50	amino acid	cytochrome P-450	CHEBI:33704	100328948(Tax:9986)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Complete amino_acid sequence of a cytochrome_P-450 isolated from beta-naphthoflavone-induced rabbit liver microsomes .
3027695	0	amino_acid	17,27	cytochrome_P-450_isozyme_3a	71,98	amino acid	cytochrome P-450 isozyme 3a	CHEBI:33704	100342572(Tax:9986)	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	cDNA and derived amino_acid sequence of ethanol-inducible rabbit liver cytochrome_P-450_isozyme_3a -LRB- P-450ALC -RRB- .
7793977	0	amino_acid	34,44	cytochrome_P4501A1	57,75	amino acid	cytochrome P4501A1	CHEBI:33704	1543	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Functional assessment of specific amino_acid residues of cytochrome_P4501A1 using anti-peptide antibodies .
8651689	0	amino_acid	58,68	cytochrome_P4501A1	39,57	amino acid	cytochrome P4501A1	CHEBI:33704	1543	Chemical	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification and characterization of cytochrome_P4501A1 amino_acid residues interacting with a radiolabeled photoaffinity diazido-benzphetamine analogue .
9637728	0	amino_acid	12,22	cytochrome_b	40,52	amino acid	cytochrome b	CHEBI:33704	801484(Tax:3055)	Chemical	Gene	substitutions|amod|START_ENTITY substitutions|nmod|END_ENTITY	Two unusual amino_acid substitutions in cytochrome_b of the colorless alga Polytomella spp. : correlation with the atypical spectral properties of the bH heme .
11452873	0	amino_acid	4,14	cytochrome_c	51,63	amino acid	cytochrome c	CHEBI:33704	106401631	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|nsubj|sequence	The amino_acid sequence of rape -LRB- Brassica_Napus_L -RRB- cytochrome_c .
194585	0	amino_acid	4,14	cytochrome_c	27,39	amino acid	cytochrome c	CHEBI:33704	54205	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The amino_acid sequence of cytochrome_c from the locust , Schistocerca gregaria Forskal .
202328	0	amino_acid	4,14	cytochrome_c	27,39	amino acid	cytochrome c	CHEBI:33704	34995(Tax:7227)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The amino_acid sequence of cytochrome_c from the blowfly Lucilia cuprina .
4352905	0	amino_acid	4,14	cytochrome_c	27,39	amino acid	cytochrome c	CHEBI:33704	54205	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The amino_acid sequence of cytochrome_c from Allium porrum L. -LRB- leek -RRB- .
4353234	0	amino_acid	4,14	cytochrome_c	27,39	amino acid	cytochrome c	CHEBI:33704	54205	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The amino_acid sequence of cytochrome_c from Nigella damascena L. -LRB- love-in-a-mist -RRB- .
5131733	0	amino_acid	4,14	cytochrome_c	27,39	amino acid	cytochrome c	CHEBI:33704	54205	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The amino_acid sequence of cytochrome_c from Cucurbita maxima L. -LRB- pumpkin -RRB- .
5131734	0	amino_acid	4,14	cytochrome_c	27,39	amino acid	cytochrome c	CHEBI:33704	106301472	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The amino_acid sequence of cytochrome_c of Fagopyrum esculentum Moench -LRB- buckwheat -RRB- and Brassica_oleracea_L .
5933874	0	amino_acid	4,14	cytochrome_c	40,52	amino acid	cytochrome c	CHEBI:33704	104968582	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The amino_acid sequence of bovine heart cytochrome_c .
1322638	0	amino_acid	105,115	cytochrome_c_oxidase_subunit_I	128,158	amino acid	cytochrome c oxidase subunit I	CHEBI:33704	4512	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	A mitochondrial DNA variant , identified in Leber_hereditary_optic_neuropathy patients , which extends the amino_acid sequence of cytochrome_c_oxidase_subunit_I .
6262719	0	amino_acid	32,42	cytochrome_c_oxidase_subunits_I_and_II	61,99	amino acid	cytochrome c oxidase subunits I and II	CHEBI:33704	4512;4513	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Alignment of the amino terminal amino_acid sequence of human cytochrome_c_oxidase_subunits_I_and_II with the sequence of their putative mRNAs .
8178153	3	amino_acid	476,486	dTAFII150	499,508	amino acid	dTAFII150	CHEBI:33704	39164(Tax:7227)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The deduced primary amino_acid sequence of dTAFII150 reveals a striking similarity to the essential yeast gene , TSM-1 .
7927337	0	amino_acid	43,53	debrisoquine_4-hydroxylase	66,92	amino acid	debrisoquine 4-hydroxylase	CHEBI:33704	1565	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	DNA haplotype-dependent differences in the amino_acid sequence of debrisoquine_4-hydroxylase -LRB- CYP2D6 -RRB- : evidence for two major allozymes in extensive metabolisers .
5901046	0	amino_acid	4,14	delta-5-3-ketosteroid_isomerase	42,73	amino acid	delta-5-3-ketosteroid isomerase	CHEBI:33704	3283	Chemical	Gene	composition|amod|START_ENTITY composition|nmod|END_ENTITY	The amino_acid composition of crystalline delta-5-3-ketosteroid_isomerase and its tryptic peptides .
16453447	0	amino_acid	4,14	desmin	46,52	amino acid	desmin	CHEBI:33704	395906(Tax:9031)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The amino_acid sequence of chicken and muscle desmin provides a common structural model for intermediate filament proteins .
6202512	0	amino_acid	4,14	desmin	42,48	amino acid	desmin	CHEBI:33704	395906(Tax:9031)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The amino_acid sequence of chicken muscle desmin provides a common structural model for intermediate filament proteins .
12384595	0	amino_acid	27,37	dihydrofolate_reductase	56,79	amino acid	dihydrofolate reductase	CHEBI:33704	1719	Chemical	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	Identification of critical amino_acid residues on human dihydrofolate_reductase protein that mediate RNA recognition .
762074	0	amino_acid	4,14	dihydrofolate_reductase	27,50	amino acid	dihydrofolate reductase	CHEBI:33704	13361(Tax:10090)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The amino_acid sequence of dihydrofolate_reductase from the mouse_lymphoma_L1210 .
25518718	0	amino_acid	73,83	dipeptidyl_peptidase_4	116,138	amino acid	dipeptidyl peptidase 4	CHEBI:33704	1803	Chemical	Gene	structure|amod|START_ENTITY structure|nmod|END_ENTITY	Association of host tropism of Middle East syndrome coronavirus with the amino_acid structure of host cell receptor dipeptidyl_peptidase_4 .
2295597	0	amino_acid	8,18	dopamine_beta-hydroxylase	38,63	amino acid	dopamine beta-hydroxylase	CHEBI:33704	1621	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Primary amino_acid sequence of bovine dopamine_beta-hydroxylase .
17890375	0	amino_acid	45,55	eIF4E	73,78	amino acid	eIF4E	CHEBI:33704	1977	Chemical	Gene	substitutions|amod|START_ENTITY substitutions|nmod|END_ENTITY	Functional dissection of naturally occurring amino_acid substitutions in eIF4E that confers recessive potyvirus resistance in plants .
20860996	0	amino_acid	9,19	eRF1	61,65	amino acid	eRF1	CHEBI:33704	2107	Chemical	Gene	change|amod|START_ENTITY change|nmod|END_ENTITY	A single amino_acid change of translation termination factor eRF1 switches between bipotent and omnipotent stop-codon specificity .
3634756	0	amino_acid	8,18	elastase_II	39,50	amino acid	elastase II	CHEBI:33704	282687(Tax:9913)	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Partial amino_acid sequence of porcine elastase_II .
10562423	0	amino_acid	51,61	elastin	96,103	amino acid	elastin	CHEBI:33704	280781(Tax:9913)	Chemical	Gene	START_ENTITY|nmod|hydrolysate hydrolysate|nmod|END_ENTITY	Cyclopentenosine , major trifunctional crosslinking amino_acid isolated from acid hydrolysate of elastin .
11083059	0	amino_acid	26,36	elastin	94,101	amino acid	elastin	CHEBI:33704	2006	Chemical	Gene	sequence|amod|START_ENTITY structure|nmod|sequence expressed|nsubj|structure expressed|dobj|exon exon|nmod|END_ENTITY	Solution structure of the amino_acid sequence coded by the rarely expressed exon 26A of human elastin : the N-terminal region .
1420992	0	amino_acid	18,28	elastin	140,147	amino acid	elastin	CHEBI:33704	2006	Chemical	Gene	residues|amod|START_ENTITY Hydrophobicity|nmod|residues Hydrophobicity|dep|differential differential|acl|scanning scanning|dobj|calorimetry calorimetry|nmod|analogues analogues|nmod|polypentapeptide polypentapeptide|nmod|END_ENTITY	Hydrophobicity of amino_acid residues : differential scanning calorimetry and synthesis of the aromatic analogues of the polypentapeptide of elastin .
1510679	0	amino_acid	64,74	elastin	123,130	amino acid	elastin	CHEBI:33704	280781(Tax:9913)	Chemical	Gene	START_ENTITY|nmod|hydrolysate hydrolysate|nmod|END_ENTITY	Isolation and structural characterization of a new crosslinking amino_acid , cyclopentenosine , from the acid hydrolysate of elastin .
2383264	0	amino_acid	52,62	elastin	99,106	amino acid	elastin	CHEBI:33704	280781(Tax:9913)	Chemical	Gene	START_ENTITY|xcomp|allodesmosine allodesmosine|nmod|hydrolysate hydrolysate|nmod|END_ENTITY	Isolation and characterization of new cross-linking amino_acid `` allodesmosine '' from hydrolysate of elastin .
3440088	0	amino_acid	30,40	elastin	70,77	amino acid	elastin	CHEBI:33704	280781(Tax:9913)	Chemical	Gene	sequences|compound|START_ENTITY analysis|nmod|sequences analysis|nmod|END_ENTITY	A comparative analysis of the amino_acid and cDNA sequences of bovine elastin a and chick elastin .
5943817	0	amino_acid	18,28	elastin	51,58	amino acid	elastin	CHEBI:33704	2006	Chemical	Gene	composition|amod|START_ENTITY composition|nmod|END_ENTITY	Variations in the amino_acid composition of aortic elastin from different species .
7695097	0	amino_acid	25,35	elastin	68,75	amino acid	elastin	CHEBI:33704	2006	Chemical	Gene	aldosine|appos|START_ENTITY Analysis|nmod|aldosine derived|nsubj|Analysis derived|nmod|crosslink crosslink|nmod|END_ENTITY	Analysis of aldosine , an amino_acid derived from aldol crosslink of elastin and collagen by high-performance liquid chromatography .
8561494	0	amino_acid	3,13	elastin	46,53	amino acid	elastin	CHEBI:33704	25043(Tax:10116)	Chemical	Gene	START_ENTITY|acl|derived derived|nmod|crosslink crosslink|nmod|END_ENTITY	An amino_acid derived from aldol crosslink of elastin and collagen : structure , distribution , aging , and two models of hyperglycemia .
9693009	0	amino_acid	4,14	elastin	72,79	amino acid	elastin	CHEBI:33704	2006	Chemical	Gene	sequence|amod|START_ENTITY expressed|nsubj|sequence expressed|ccomp|contains contains|nsubj|exon exon|nmod|END_ENTITY	The amino_acid sequence coded by the rarely expressed exon 26A of human elastin contains a stable beta-turn with chemotactic activity for monocytes .
19272175	0	amino_acid	36,46	endonuclease_G	65,79	amino acid	endonuclease G	CHEBI:33704	2021	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Mutagenesis identifies the critical amino_acid residues of human endonuclease_G involved in catalysis , magnesium coordination , and substrate specificity .
3539098	0	amino_acid	13,23	enolase	60,67	amino acid	enolase	CHEBI:33704	396016(Tax:9031)	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|nsubj|sequence	The complete amino_acid sequence of chicken skeletal-muscle enolase .
3920076	0	amino_acid	4,14	enterotoxin	31,42	amino acid	enterotoxin	CHEBI:33704	10874406	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The amino_acid sequence of the enterotoxin from Clostridium_perfringens type A .
3000782	0	amino_acid	38,48	epidermal_growth_factor	4,27	amino acid	epidermal growth factor	CHEBI:33704	25313(Tax:10116)	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|dep|sequence	Rat epidermal_growth_factor : complete amino_acid sequence .
8827569	0	amino_acid	47,57	epidermal_growth_factor	10,33	amino acid	epidermal growth factor	CHEBI:33704	25313(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of epidermal_growth_factor on placental amino_acid transport and regulation of epidermal_growth_factor_receptor expression of hepatocyte in rat .
9409525	0	amino_acid	63,73	epidermal_growth_factor	11,34	amino acid	epidermal growth factor	CHEBI:33704	25313(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of epidermal_growth_factor on maternal and fetal serum amino_acid levels in rats .
1429613	0	amino_acid	171,181	epsilon-subunit	194,209	amino acid	epsilon-subunit	CHEBI:33704	29422(Tax:10116)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	A simple , rapid method for purification of epsilon-subunit , coupling factor 6 , subunit d , and subunit e from rat liver H -LRB- + -RRB- - ATP synthase and determination of the complete amino_acid sequence of epsilon-subunit .
10867545	0	amino_acid	25,35	erythropoietin	85,99	amino acid	erythropoietin	CHEBI:33704	2056	Chemical	Gene	metabolism|amod|START_ENTITY changes|nmod|metabolism Evaluation|nmod|changes treated|nsubj|Evaluation treated|nmod|END_ENTITY	Evaluation of changes in amino_acid metabolism in pre-dialysis patients treated with erythropoietin .
24842400	0	amino_acid	54,64	erythropoietin	36,50	amino acid	erythropoietin	CHEBI:33704	2056	Chemical	Gene	analysis|amod|START_ENTITY END_ENTITY|nmod|analysis	Quantification of recombinant human erythropoietin by amino_acid analysis using isotope dilution liquid chromatography-tandem mass spectrometry .
2636662	0	amino_acid	14,24	erythropoietin	57,71	amino acid	erythropoietin	CHEBI:33704	2056	Chemical	Gene	metabolism|amod|START_ENTITY Correction|nmod|metabolism Correction|nmod|therapy therapy|compound|END_ENTITY	Correction of amino_acid metabolism by recombinant human erythropoietin therapy in hemodialysis patients .
8757568	0	amino_acid	55,65	erythropoietin	28,42	amino acid	erythropoietin	CHEBI:33704	2056	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of recombinant human erythropoietin on insulin , amino_acid , and lipid metabolism in uremia .
11836633	0	amino_acid	64,74	estrogen_receptor	8,25	amino acid	estrogen receptor	CHEBI:33704	2099	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of estrogen_receptor in the regulation of estrogen induced amino_acid transport of System A in breast_cancer and other receptor positive tumor cells .
21780101	0	amino_acid	33,43	ezrin	24,29	amino acid	ezrin	CHEBI:33704	7430	Chemical	Gene	residues|amod|START_ENTITY END_ENTITY|nmod|residues	P-glycoprotein binds to ezrin at amino_acid residues 149-242 in the FERM domain and plays a key role in the multidrug resistance of human osteosarcoma .
8943856	0	amino_acid	21,31	factor_VIII	52,63	amino acid	factor VIII	CHEBI:33704	2157	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	The cDNA and derived amino_acid sequence of porcine factor_VIII .
10627484	0	amino_acid	34,44	factor_Xa	63,72	amino acid	factor Xa	CHEBI:33704	2159	Chemical	Gene	substitution|amod|START_ENTITY substitution|nmod|results results|amod|END_ENTITY	Prothrombin San Antonio : a single amino_acid substitution at a factor_Xa activation site -LRB- Arg320_to_His -RRB- results in dysprothrombinemia .
11677132	0	amino_acid	30,40	factor_Xa	56,65	amino acid	factor Xa	CHEBI:33704	2159	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|inhibitors inhibitors|compound|END_ENTITY	Design , synthesis , and SAR of amino_acid derivatives as factor_Xa inhibitors .
18991406	0	amino_acid	86,96	factor_Xa	42,51	amino acid	factor Xa	CHEBI:33704	2159	Chemical	Gene	regions|amod|START_ENTITY regulation|nmod|regions regulation|nmod|activity activity|nmod|END_ENTITY	Cooperative regulation of the activity of factor_Xa within prothrombinase by discrete amino_acid regions from factor Va heavy chain .
20722419	0	amino_acid	16,26	factor_Xa	86,95	amino acid	factor Xa	CHEBI:33704	2159	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	Contribution of amino_acid region 659-663 of Factor Va heavy chain to the activity of factor_Xa within prothrombinase .
3350005	0	amino_acid	38,48	ferredoxin	65,75	amino acid	ferredoxin	CHEBI:33704	5716653(Tax:3055)	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Purification , properties and complete amino_acid sequence of the ferredoxin from a green alga , Chlamydomonas_reinhardtii .
486088	0	amino_acid	4,14	ferredoxin	27,37	amino acid	ferredoxin	CHEBI:33704	542942(Tax:4565)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The amino_acid sequence of ferredoxin from Triticum_aestivum -LRB- wheat -RRB- .
11947453	0	amino_acid	11,21	fibrinogen	47,57	amino acid	fibrinogen	CHEBI:33704	2244	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	N-terminal amino_acid sequence of intact human fibrinogen .
12706644	0	amino_acid	68,78	fibrinogen	49,59	amino acid	fibrinogen	CHEBI:33704	2244	Chemical	Gene	exchange|amod|START_ENTITY END_ENTITY|nmod|exchange	Fibrinogen Magdeburg I : a novel variant of human fibrinogen with an amino_acid exchange in the fibrinopeptide A -LRB- Aalpha 9 , Leu -- > Pro -RRB- .
16363805	0	amino_acid	19,29	fibrinogen	71,81	amino acid	fibrinogen	CHEBI:33704	2244	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|sequence sequence|nmod|END_ENTITY	A cluster of basic amino_acid residues in the gamma370-381 sequence of fibrinogen comprises a binding site for platelet integrin alpha -LRB- IIb -RRB- beta3 -LRB- glycoprotein IIb/IIIa -RRB- .
22967385	0	amino_acid	93,103	fibrinogen	120,130	amino acid	fibrinogen	CHEBI:33704	2244	Chemical	Gene	substitution|amod|START_ENTITY caused|nmod|substitution caused|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Genotype and function analyses of four inherited_dysfibrinogenemia pedigree caused by Arg16 amino_acid substitution in fibrinogen Aa chain -RSB- .
3368448	0	amino_acid	18,28	fibrinogen	95,105	amino acid	fibrinogen	CHEBI:33704	2244	Chemical	Gene	START_ENTITY|dobj|sequences sequences|nmod|forms forms|nmod|chain chain|nmod|END_ENTITY	Carboxyl-terminal amino_acid sequences of two variant forms of the gamma chain of human plasma fibrinogen .
3563970	0	amino_acid	49,59	fibrinogen	15,25	amino acid	fibrinogen	CHEBI:33704	2244	Chemical	Gene	substitution|amod|START_ENTITY variants|nmod|substitution variants|compound|END_ENTITY	Three abnormal fibrinogen variants with the same amino_acid substitution -LRB- gamma 275_Arg -- His -RRB- : fibrinogens Bergamo II , Essen and Perugia .
3708159	0	amino_acid	41,51	fibrinogen	20,30	amino acid	fibrinogen	CHEBI:33704	2244	Chemical	Gene	gamma|amod|START_ENTITY 330_Asp|dep|gamma I|parataxis|330_Asp I|dep|Characterization Characterization|nmod|Milano Milano|compound|END_ENTITY	Characterization of fibrinogen Milano I : amino_acid exchange gamma 330_Asp -- Val impairs fibrin polymerization .
6648427	0	amino_acid	56,66	fibrinogen	32,42	amino acid	fibrinogen	CHEBI:33704	2244	Chemical	Gene	substitution|amod|START_ENTITY variant|nmod|substitution variant|compound|END_ENTITY	-LSB- Fibrinogen Bern II : hereditary fibrinogen variant with amino_acid substitution of arginine_replaced_by_histidine_in_position_16 of the A alpha chain -RSB- .
8470043	0	amino_acid	85,95	fibrinogen_gamma-chain	112,134	amino acid	fibrinogen gamma-chain	CHEBI:33704	2266	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Paris I_dysfibrinogenemia : a point mutation in intron 8 results in insertion of a 15 amino_acid sequence in the fibrinogen_gamma-chain .
6159580	0	amino_acid	13,23	fibroblast_interferon	42,63	amino acid	fibroblast interferon	CHEBI:33704	3456	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The complete amino_acid sequence of human fibroblast_interferon as deduced using synthetic oligodeoxyribonucleotide primers of reverse transcriptase .
6160579	0	amino_acid	13,23	fibroblast_interferon	42,63	amino acid	fibroblast interferon	CHEBI:33704	3456	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	NH2-terminal amino_acid sequence of human fibroblast_interferon .
2538429	0	amino_acid	13,23	folate_binding_protein	44,66	amino acid	folate binding protein	CHEBI:33704	2348	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The complete amino_acid sequence of a human folate_binding_protein from KB cells determined from the cDNA .
17978468	0	amino_acid	22,32	galectin	57,65	amino acid	galectin	CHEBI:33704	183761(Tax:6239)	Chemical	Gene	residue|amod|START_ENTITY residue|nmod|END_ENTITY	Identification of the amino_acid residue in the nematode galectin LEC-1 responsible for its unique sugar binding property : analysis by combination of site-directed mutagenesis and frontal affinity chromatography .
6283552	0	amino_acid	41,51	gamma-trace	6,17	amino acid	gamma-trace	CHEBI:33704	1471	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|dep|sequence	Human gamma-trace , a basic microprotein : amino_acid sequence and presence in the adenohypophysis .
7057928	0	amino_acid	14,24	gastrin	55,62	amino acid	gastrin	CHEBI:33704	2520	Chemical	Gene	uptake|amod|START_ENTITY uptake|nmod|END_ENTITY	Importance of amino_acid uptake and decarboxylation in gastrin release from isolated G cells .
7309377	2	amino_acid	92,102	gastrin-releasing_peptide	115,140	amino acid	gastrin-releasing peptide	CHEBI:33704	2922	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Synthesis of a heptacosapeptide amide corresponding to the entire amino_acid sequence of gastrin-releasing_peptide .
2196564	0	amino_acid	9,19	glia_maturation_factor_beta	39,66	amino acid	glia maturation factor beta	CHEBI:33704	615255(Tax:9913)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Complete amino_acid sequence of bovine glia_maturation_factor_beta .
19702274	0	amino_acid	7,17	glucagon-like_peptide-1_receptor	18,50	amino acid	glucagon-like peptide-1 receptor	CHEBI:33704	14652(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|agonists agonists|amod|END_ENTITY	Eleven amino_acid glucagon-like_peptide-1_receptor agonists with antidiabetic activity .
10566686	0	amino_acid	16,26	glucocorticoid_receptor	60,83	amino acid	glucocorticoid receptor	CHEBI:33704	2908	Chemical	Gene	Insertion|nmod|START_ENTITY Insertion|nmod|END_ENTITY	Insertion of an amino_acid in the DNA-binding domain of the glucocorticoid_receptor as a result of alternative splicing .
15220338	0	amino_acid	9,19	glucocorticoid_receptor	85,108	amino acid	glucocorticoid receptor	CHEBI:33704	2908	Chemical	Gene	change|amod|START_ENTITY change|nmod|finger finger|nmod|domain domain|nmod|END_ENTITY	A single amino_acid change in the first zinc finger of the DNA binding domain of the glucocorticoid_receptor regulates differential promoter selectivity .
1704018	0	amino_acid	32,42	glucocorticoid_receptor	93,116	amino acid	glucocorticoid receptor	CHEBI:33704	2908	Chemical	Gene	substitution|amod|START_ENTITY causing|dobj|substitution causing|nmod|domain domain|nmod|END_ENTITY	Point mutation causing a single amino_acid substitution in the hormone binding domain of the glucocorticoid_receptor in familial glucocorticoid resistance .
24127590	0	amino_acid	44,54	glucocorticoid_receptor	93,116	amino acid	glucocorticoid receptor	CHEBI:33704	2908	Chemical	Gene	insertion|nmod|START_ENTITY rewires|nsubj|insertion rewires|nmod|isoforms isoforms|compound|END_ENTITY	A naturally occurring insertion of a single amino_acid rewires transcriptional regulation by glucocorticoid_receptor isoforms .
9001247	0	amino_acid	20,30	glucocorticoid_receptor	85,108	amino acid	glucocorticoid receptor	CHEBI:33704	2908	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	Role of hydrophobic amino_acid clusters in the transactivation activity of the human glucocorticoid_receptor .
2909525	0	amino_acid	4,14	glucokinase	37,48	amino acid	glucokinase	CHEBI:33704	24385(Tax:10116)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The amino_acid sequence of rat liver glucokinase deduced from cloned cDNA .
23252580	0	amino_acid	147,157	glucose_6-phosphate_dehydrogenase	35,68	amino acid	glucose 6-phosphate dehydrogenase	CHEBI:33704	281179(Tax:9913)	Chemical	Gene	residues|amod|START_ENTITY role|nmod|residues modification|dep|role modification|nmod|and_bovine_eye_lens_proteins and_bovine_eye_lens_proteins|amod|_ _|amod|END_ENTITY	Chemical modification of lysozyme , glucose_6-phosphate_dehydrogenase , _ and_bovine_eye_lens_proteins induced by peroxyl radicals : role of oxidizable amino_acid residues .
435122	0	amino_acid	69,79	glucose_dehydrogenase	11,32	amino acid	glucose dehydrogenase	CHEBI:33704	9563	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of glucose_dehydrogenase in converting urea and ammonia into amino_acid using artificial cells .
8663156	0	amino_acid	3,13	glutamate-gated_chloride_channel	51,83	amino acid	glutamate-gated chloride channel	CHEBI:33704	178930(Tax:6239)	Chemical	Gene	substitution|amod|START_ENTITY substitution|nmod|region region|nmod|END_ENTITY	An amino_acid substitution in the pore region of a glutamate-gated_chloride_channel enables the coupling of ligand binding to channel gating .
1740158	0	amino_acid	4,14	glutamate_decarboxylase	27,50	amino acid	glutamate decarboxylase	CHEBI:33704	2752	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The amino_acid sequence of glutamate_decarboxylase from Escherichia_coli .
6547043	0	amino_acid	108,118	glutathione_transferase_Ya_subunit	139,173	amino acid	glutathione transferase Ya subunit	CHEBI:33704	494499(Tax:10116)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Construction and characterization of a plasmid containing complementary DNA to mRNA encoding the N-terminal amino_acid sequence of the rat glutathione_transferase_Ya_subunit .
7734343	0	amino_acid	114,124	glycophorins_C_and_D	172,192	amino acid	glycophorins C and D	CHEBI:33704	2995	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Reactivity with erythroid and non-erythroid tissues of a murine monoclonal antibody to a synthetic peptide having amino_acid sequence common to cytoplasmic domain of human glycophorins_C_and_D .
10379888	0	amino_acid	46,56	gonadotropin-releasing_hormone_receptor	97,136	amino acid	gonadotropin-releasing hormone receptor	CHEBI:33704	2798	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Influence of a species-specific extracellular amino_acid on expression and function of the human gonadotropin-releasing_hormone_receptor .
12852498	0	amino_acid	74,84	gonadotropin_releasing_hormone	107,137	amino acid	gonadotropin releasing hormone	CHEBI:33704	2796	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Use of a highly specific monoclonal antibody against the central variable amino_acid sequence of mammalian gonadotropin_releasing_hormone to evaluate GnRH-I tissue distribution compared with GnRH-I binding sites in adult male rats .
10756049	0	amino_acid	16,26	gp120	82,87	amino acid	gp120	CHEBI:33704	155971(Tax:11676)	Chemical	Gene	variability|amod|START_ENTITY variability|nmod|glycoprotein glycoprotein|amod|END_ENTITY	Reevaluation of amino_acid variability of the human_immunodeficiency_virus_type_1 gp120 envelope glycoprotein and prediction of new discontinuous epitopes .
12610158	0	amino_acid	10,20	gp120	121,126	amino acid	gp120	CHEBI:33704	155971(Tax:11676)	Chemical	Gene	substitution|amod|START_ENTITY Effect|nmod|substitution Effect|nmod|END_ENTITY	Effect of amino_acid substitution of the V3 and bridging sheet residues in human_immunodeficiency_virus_type_1 subtype C gp120 on CCR5 utilization .
1409653	0	amino_acid	6,16	gp120	59,64	amino acid	gp120	CHEBI:33704	155971(Tax:11676)	Chemical	Gene	changes|amod|START_ENTITY changes|nmod|region region|nmod|END_ENTITY	Small amino_acid changes in the V3 hypervariable region of gp120 can affect the T-cell-line and macrophage tropism of human_immunodeficiency_virus_type_1 .
15045488	0	amino_acid	11,21	gp120	85,90	amino acid	gp120	CHEBI:33704	155971(Tax:11676)	Chemical	Gene	variation|amod|START_ENTITY Linkage|nmod|variation Linkage|nmod|glycoprotein glycoprotein|amod|END_ENTITY	Linkage of amino_acid variation and evolution of human_immunodeficiency_virus_type_1 gp120 envelope glycoprotein -LRB- subtype B -RRB- with usage of the second receptor .
1703212	0	amino_acid	88,98	gp120	127,132	amino acid	gp120	CHEBI:33704	155971(Tax:11676)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Glycosylation governs the binding of antipeptide antibodies to regions of hypervariable amino_acid sequence within recombinant gp120 of human_immunodeficiency_virus_type_1 .
18160142	0	amino_acid	86,96	gp120	130,135	amino acid	gp120	CHEBI:33704	155971(Tax:11676)	Chemical	Gene	substitution|amod|START_ENTITY substitution|nmod|region region|nmod|END_ENTITY	Altered sensitivity of an R5X4 HIV-1_strain 89.6 to coreceptor inhibitors by a single amino_acid substitution in the V3 region of gp120 .
19776131	0	amino_acid	73,83	gp120	67,72	amino acid	gp120	CHEBI:33704	155971(Tax:11676)	Chemical	Gene	START_ENTITY|nsubj|analysis analysis|nmod|END_ENTITY	Structure-function analysis of human_immunodeficiency_virus_type_1 gp120 amino_acid mutations associated with resistance to the CCR5 coreceptor antagonist vicriviroc .
21036380	0	amino_acid	18,28	gp120	137,142	amino acid	gp120	CHEBI:33704	155971(Tax:11676)	Chemical	Gene	substitutions|amod|START_ENTITY Identification|nmod|substitutions associated|nsubj|Identification associated|nmod|phenotype phenotype|nmod|END_ENTITY	Identification of amino_acid substitutions associated with neutralization phenotype in the human_immunodeficiency_virus_type-1 subtype C gp120 .
21851958	0	amino_acid	9,19	gp120	53,58	amino acid	gp120	CHEBI:33704	155971(Tax:11676)	Chemical	Gene	substitution|amod|START_ENTITY substitution|nmod|region region|nmod|END_ENTITY	A single amino_acid substitution in the C4 region in gp120 confers enhanced neutralization of HIV-1 by modulating CD4 binding sites and V3 loop .
24758333	0	amino_acid	10,20	gp120	130,135	amino acid	gp120	CHEBI:33704	155971(Tax:11676)	Chemical	Gene	substitutions|amod|START_ENTITY Impact|nmod|substitutions Impact|nmod|END_ENTITY	Impact of amino_acid substitutions in the V2 and C2 regions of human_immunodeficiency_virus_type_1 CRF01_AE envelope_glycoprotein gp120 on viral neutralization susceptibility to broadly neutralizing antibodies specific for the CD4 binding site .
7507184	0	amino_acid	142,152	gp120	103,108	amino acid	gp120	CHEBI:33704	3700	Chemical	Gene	change|amod|START_ENTITY conferred|nmod|change conferred|nsubj|Resistance Resistance|nmod|neutralization neutralization|nmod|antibodies antibodies|nmod|glycoprotein glycoprotein|amod|END_ENTITY	Resistance to neutralization by broadly reactive antibodies to the human_immunodeficiency_virus_type_1 gp120 glycoprotein conferred by a gp41 amino_acid change .
7642208	0	amino_acid	23,33	gp120	75,80	amino acid	gp120	CHEBI:33704	155971(Tax:11676)	Chemical	Gene	substitution|amod|START_ENTITY effect|nmod|substitution effect|nmod|HIV-1 HIV-1|nummod|END_ENTITY	The effect of a single amino_acid substitution within the V3 loop of HIV-1 gp120 on HLA-DR1-restricted CD4 T-cell recognition .
7688820	0	amino_acid	172,182	gp120	193,198	amino acid	gp120	CHEBI:33704	155971(Tax:11676)	Chemical	Gene	change|amod|START_ENTITY change|nmod|END_ENTITY	Resistance of a human serum-selected human_immunodeficiency_virus_type_1 escape mutant to neutralization by CD4 binding site monoclonal antibodies is conferred by a single amino_acid change in gp120 .
7856100	0	amino_acid	6,16	gp120	148,153	amino acid	gp120	CHEBI:33704	155971(Tax:11676)	Chemical	Gene	changes|amod|START_ENTITY affect|nsubj|changes affect|dobj|function function|nmod|END_ENTITY	Small amino_acid sequence changes within the V2 domain can affect the function of a T-cell line-tropic human_immunodeficiency_virus_type_1 envelope gp120 .
8497073	0	amino_acid	9,19	gp120	87,92	amino acid	gp120	CHEBI:33704	155971(Tax:11676)	Chemical	Gene	substitution|amod|START_ENTITY substitution|nmod|loop loop|nmod|END_ENTITY	A single amino_acid substitution in the V1 loop of human_immunodeficiency_virus_type_1 gp120 alters cellular tropism .
8497077	0	amino_acid	10,20	gp120	92,97	amino acid	gp120	CHEBI:33704	155971(Tax:11676)	Chemical	Gene	changes|amod|START_ENTITY Effect|nmod|changes Effect|nmod|glycoprotein glycoprotein|amod|END_ENTITY	Effect of amino_acid changes in the V1/V2 region of the human_immunodeficiency_virus_type_1 gp120 glycoprotein on subunit association , syncytium formation , and recognition by a neutralizing antibody .
8523579	0	amino_acid	7,17	gp120	60,65	amino acid	gp120	CHEBI:33704	155971(Tax:11676)	Chemical	Gene	substitution|amod|START_ENTITY Single|dep|substitution Single|dep|1 1|nmod|causes causes|amod|END_ENTITY	Single amino_acid substitution in constant region 1 or 4 of gp120 causes the phenotype of a human_immunodeficiency_virus_type_1 variant with mutations in hypervariable regions 1 and 2 to revert .
8573370	0	amino_acid	53,63	gp120	109,114	amino acid	gp120	CHEBI:33704	155971(Tax:11676)	Chemical	Gene	substitution|amod|START_ENTITY predict|dobj|substitution predict|nmod|region region|nmod|END_ENTITY	Fine specificity of antibody recognition may predict amino_acid substitution in the third variable region of gp120 during HIV_type_1_infection .
15756648	3	amino_acid	421,431	gp49B	408,413	amino acid	gp49B	CHEBI:33704	292594(Tax:10116)	Chemical	Gene	level|amod|START_ENTITY END_ENTITY|nmod|level	We have cloned several rat cDNA , 78 % identical to mouse gp49B at the amino_acid level , that represent the rat orthologue to mouse gp49B .
1604817	0	amino_acid	4,14	granulin	43,51	amino acid	granulin	CHEBI:33704	2896	Chemical	Gene	determination|amod|START_ENTITY determination|nmod|END_ENTITY	The amino_acid sequence determination of a granulin and polyhedrin from two baculoviruses infecting Agrotis segetum .
10527818	0	amino_acid	31,41	growth_hormone	68,82	amino acid	growth hormone	CHEBI:33704	14599(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|overexpressing overexpressing|amod|END_ENTITY	Placental anionic and cationic amino_acid transporter expression in growth_hormone overexpressing and null IGF-II or null IGF-I_receptor mice .
1123321	1	amino_acid	69,79	growth_hormone	121,135	amino acid	growth hormone	CHEBI:33704	2688	Chemical	Gene	sequence|amod|START_ENTITY Revision|nmod|sequence Revision|nmod|fragment fragment|nmod|END_ENTITY	Revision of the amino_acid sequence of an active fragment of bovine growth_hormone .
12467536	0	amino_acid	83,93	growth_hormone	34,48	amino acid	growth hormone	CHEBI:33704	2688	Chemical	Gene	chain|acl|START_ENTITY metabolism|nmod|chain -LSB-|nmod|metabolism -LSB-|dobj|effects effects|nmod|END_ENTITY	-LSB- The effects of recombinant human growth_hormone on the metabolism of branch chain amino_acid in severely burned patients -RSB- .
14411269	0	amino_acid	15,25	growth_hormone	61,75	amino acid	growth hormone	CHEBI:33704	81668(Tax:10116)	Chemical	Gene	transport|amod|START_ENTITY transport|nmod|diaphragm diaphragm|nmod|END_ENTITY	Stimulation of amino_acid transport in isolated diaphragm by growth_hormone added in vitro .
16332656	0	amino_acid	49,59	growth_hormone	18,32	amino acid	growth hormone	CHEBI:33704	2688	Chemical	Gene	uptake|compound|START_ENTITY improves|dobj|uptake improves|nsubj|END_ENTITY	Recombinant human growth_hormone improves muscle amino_acid uptake and whole-body protein metabolism in chronic hemodialysis patients .
1859828	0	amino_acid	13,23	growth_hormone	36,50	amino acid	growth hormone	CHEBI:33704	378781(Tax:9031)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The complete amino_acid sequence of growth_hormone of the bullfrog -LRB- Rana catesbeiana -RRB- .
1999173	0	amino_acid	9,19	growth_hormone	101,115	amino acid	growth hormone	CHEBI:33704	81668(Tax:10116)	Chemical	Gene	analysis|amod|START_ENTITY isolated|nsubj|analysis isolated|nmod|thymus thymus|acl:relcl|enhances enhances|dobj|release release|nmod|END_ENTITY	Complete amino_acid sequence analysis of a peptide isolated from the thymus that enhances release of growth_hormone and prolactin .
20259084	0	amino_acid	4,14	growth_hormone	51,65	amino acid	growth hormone	CHEBI:33704	2688	Chemical	Gene	composition|amod|START_ENTITY END_ENTITY|nsubj|composition	The amino_acid composition of anterior hypophyseal growth_hormone .
21840008	0	amino_acid	42,52	growth_hormone	24,38	amino acid	growth hormone	CHEBI:33704	2688	Chemical	Gene	analysis|amod|START_ENTITY END_ENTITY|nmod|analysis	Quantification of human growth_hormone by amino_acid composition analysis using isotope dilution liquid-chromatography tandem mass spectrometry .
2707584	0	amino_acid	13,23	growth_hormone	36,50	amino acid	growth hormone	CHEBI:33704	378781(Tax:9031)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The complete amino_acid sequence of growth_hormone of an elasmobranch , the blue shark -LRB- Prionace glauca -RRB- .
3276499	0	amino_acid	39,49	growth_hormone	21,35	amino acid	growth hormone	CHEBI:33704	2688	Chemical	Gene	transport|amod|START_ENTITY END_ENTITY|nmod|transport	The acute effects of growth_hormone on amino_acid transport and protein synthesis are due to its insulin-like action .
4320596	0	amino_acid	75,85	growth_hormone	57,71	amino acid	growth hormone	CHEBI:33704	2688	Chemical	Gene	transport|amod|START_ENTITY Inhibition|nmod|transport Inhibition|nmod|theophylline theophylline|nmod|effects effects|nmod|END_ENTITY	Inhibition by theophylline of the stimulatory effects of growth_hormone on amino_acid transport and protein synthesis in muscle .
5239681	0	amino_acid	35,45	growth_hormone	17,31	amino acid	growth hormone	CHEBI:33704	2688	Chemical	Gene	transport|amod|START_ENTITY effects|nmod|transport effects|nmod|END_ENTITY	Rapid effects of growth_hormone on amino_acid transport and protein synthesis .
5353056	0	amino_acid	41,51	growth_hormone	11,25	amino acid	growth hormone	CHEBI:33704	81668(Tax:10116)	Chemical	Gene	transport|amod|START_ENTITY Effects|nmod|transport Effects|nmod|END_ENTITY	Effects of growth_hormone and insulin on amino_acid transport in perfused rat heart .
5694238	2	amino_acid	101,111	growth_hormone	74,88	amino acid	growth hormone	CHEBI:33704	81668(Tax:10116)	Chemical	Gene	uptake|amod|START_ENTITY vitro|nmod|uptake action|acl|vitro action|nmod|END_ENTITY	Biphasic action of growth_hormone in vitro on amino_acid and pentose uptake .
5694239	0	amino_acid	55,65	growth_hormone	29,43	amino acid	growth hormone	CHEBI:33704	81668(Tax:10116)	Chemical	Gene	transport|amod|START_ENTITY effects|nmod|transport effects|nsubj|relationship relationship|nmod|END_ENTITY	Temporal relationship of the growth_hormone effects on amino_acid transport and protein synthesis in isolated rat diaphragm .
6072696	2	amino_acid	100,110	growth_hormone	82,96	amino acid	growth hormone	CHEBI:33704	81668(Tax:10116)	Chemical	Gene	uptake|amod|START_ENTITY effects|nmod|uptake effects|nmod|END_ENTITY	Early and late effects of growth_hormone on amino_acid and pentose uptake .
744032	0	amino_acid	56,66	growth_hormone	29,43	amino acid	growth hormone	CHEBI:33704	81668(Tax:10116)	Chemical	Gene	transport|amod|START_ENTITY vitro|nmod|transport synthesis|amod|vitro course|nmod|synthesis course|nmod|effect effect|nmod|END_ENTITY	Time course of the effect of growth_hormone in vitro on amino_acid and monosaccharide transport and on protein synthesis in diaphragm of young normal rats .
7969775	0	amino_acid	21,31	growth_hormone	66,80	amino acid	growth hormone	CHEBI:33704	2688	Chemical	Gene	START_ENTITY|nmod|secretion secretion|nmod|END_ENTITY	Effect of excitatory amino_acid receptor agonists on secretion of growth_hormone as assessed by the reverse hemolytic plaque assay .
8114117	0	amino_acid	49,59	growth_hormone	76,90	amino acid	growth hormone	CHEBI:33704	2688	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Molecular phylogeny of bony fishes , based on the amino_acid sequence of the growth_hormone .
8175957	0	amino_acid	32,42	growth_hormone	6,20	amino acid	growth hormone	CHEBI:33704	2688	Chemical	Gene	metabolism|compound|START_ENTITY Acute|nmod|metabolism Acute|dobj|effects effects|amod|END_ENTITY	Acute growth_hormone effects on amino_acid and lipid metabolism .
8220394	0	amino_acid	9,19	growth_hormone	63,77	amino acid	growth hormone	CHEBI:33704	2688	Chemical	Gene	supplementation|amod|START_ENTITY supplementation|dep|effects effects|nmod|END_ENTITY	Low-dose amino_acid supplementation : no effects on serum human growth_hormone and insulin in male weightlifters .
8220395	0	amino_acid	27,37	growth_hormone	68,82	amino acid	growth hormone	CHEBI:33704	2688	Chemical	Gene	Failure|nmod|START_ENTITY supplements|nsubj|Failure supplements|xcomp|increase increase|dobj|concentrations concentrations|compound|END_ENTITY	Failure of commercial oral amino_acid supplements to increase serum growth_hormone concentrations in male body-builders .
8807592	0	amino_acid	68,78	growth_hormone	29,43	amino acid	growth hormone	CHEBI:33704	2688	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of recombinant human growth_hormone on plasma and dialysate amino_acid profiles in CAPD patients .
9063764	0	amino_acid	16,26	growth_hormone	71,85	amino acid	growth hormone	CHEBI:33704	2688	Chemical	Gene	ingestion|amod|START_ENTITY effect|nmod|ingestion exercise|nsubj|effect exercise|nmod|concentration concentration|compound|END_ENTITY	Acute effect of amino_acid ingestion and resistance exercise on plasma growth_hormone concentration in young men .
9276733	0	amino_acid	50,60	growth_hormone	22,36	amino acid	growth hormone	CHEBI:33704	2688	Chemical	Gene	substitution|amod|START_ENTITY caused|nmod|substitution caused|nsubj|END_ENTITY	Biologically inactive growth_hormone caused by an amino_acid substitution .
9579229	0	amino_acid	19,29	growth_hormone	73,87	amino acid	growth hormone	CHEBI:33704	2688	Chemical	Gene	START_ENTITY|ccomp|responsible responsible|nmod|response response|compound|END_ENTITY	The altered plasma amino_acid pattern is responsible for the paradoxical growth_hormone response to the oral glucose tolerance test in liver_cirrhosis .
1873033	0	amino_acid	88,98	growth_inhibitory_factor	4,28	amino acid	growth inhibitory factor	CHEBI:33704	4504	Chemical	Gene	protein|amod|START_ENTITY protein|nsubj|END_ENTITY	The growth_inhibitory_factor that is deficient in the Alzheimer 's _ disease brain is a 68 amino_acid metallothionein-like protein .
9174363	0	amino_acid	15,25	hCAT-1	39,45	amino acid	hCAT-1	CHEBI:33704	6541	Chemical	Gene	transporters|amod|START_ENTITY transporters|amod|END_ENTITY	Human cationic amino_acid transporters hCAT-1 , hCAT-2A , and hCAT-2B : three related carriers with distinct transport properties .
11292842	0	amino_acid	94,104	hMLH3	121,126	amino acid	hMLH3	CHEBI:33704	27030	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	The interacting domains of three MutL heterodimers in man : hMLH1 interacts with 36 homologous amino_acid residues within hMLH3 , hPMS1 and hPMS2 .
11414754	0	amino_acid	14,24	hNAT3	38,43	amino acid	hNAT3	CHEBI:33704	55089	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	A novel human amino_acid transporter , hNAT3 : cDNA cloning , chromosomal mapping , genomic structure , expression , and functional characterization .
15145940	0	amino_acid	9,19	hOAT1	94,99	amino acid	hOAT1	CHEBI:33704	9356	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Critical amino_acid residues in transmembrane domain 1 of the human organic anion transporter hOAT1 .
12527723	0	amino_acid	63,73	hPAT1	87,92	amino acid	hPAT1	CHEBI:33704	206358	Chemical	Gene	transporter|amod|START_ENTITY Structure|nmod|transporter Structure|appos|END_ENTITY	Structure , function and immunolocalization of a proton-coupled amino_acid transporter -LRB- hPAT1 -RRB- in the human intestinal cell line Caco-2 .
18621125	0	amino_acid	73,83	hPAT1	97,102	amino acid	hPAT1	CHEBI:33704	206358	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Transport of amino_acids and GABA analogues via the human proton-coupled amino_acid transporter , hPAT1 : characterization of conditions for affinity and transport experiments in Caco-2 cells .
20128809	0	amino_acid	49,59	hPAT1	81,86	amino acid	hPAT1	CHEBI:33704	206358	Chemical	Gene	transporter|amod|START_ENTITY substrate|nmod|transporter SLC36A1|amod|substrate SLC36A1|appos|END_ENTITY	Delta-aminolevulinic_acid is a substrate for the amino_acid transporter SLC36A1 -LRB- hPAT1 -RRB- .
20880398	0	amino_acid	19,29	hPAT1	52,57	amino acid	hPAT1	CHEBI:33704	206358	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|SLC36A1 SLC36A1|appos|END_ENTITY	The proton-coupled amino_acid transporter , SLC36A1 -LRB- hPAT1 -RRB- , transports Gly-Gly , Gly-Sar and other Gly-Gly mimetics .
21112392	0	amino_acid	46,56	hPAT1	81,86	amino acid	hPAT1	CHEBI:33704	206358	Chemical	Gene	START_ENTITY|dep|transporter transporter|appos|END_ENTITY	Gaboxadol has affinity for the proton-coupled amino_acid transporter 1 , SLC36A1 -LRB- hPAT1 -RRB- -- A modelling approach to determine IC -LRB- 50 -RRB- values of the three ionic species of gaboxadol .
21955456	0	amino_acid	114,124	hPAT1	140,145	amino acid	hPAT1	CHEBI:33704	206358	Chemical	Gene	START_ENTITY|dobj|1 1|appos|END_ENTITY	Three-dimensional quantitative structure-activity relationship analyses of substrates of the human proton-coupled amino_acid transporter 1 -LRB- hPAT1 -RRB- .
23488788	0	amino_acid	75,85	hPAT1	101,106	amino acid	hPAT1	CHEBI:33704	206358	Chemical	Gene	START_ENTITY|dobj|1 1|appos|END_ENTITY	Transport of the areca nut alkaloid arecaidine by the human proton-coupled amino_acid transporter 1 -LRB- hPAT1 -RRB- .
2187864	0	amino_acid	4,14	hRPB_33	70,77	amino acid	hRPB 33	CHEBI:33704	5432	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The amino_acid sequence of the human RNA polymerase II 33-kDa subunit hRPB_33 is highly conserved among eukaryotes .
7983027	0	amino_acid	15,25	hTSHr	42,47	amino acid	hTSHr	CHEBI:33704	7253	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Delineation of amino_acid residues within hTSHr 256-275 that participate in hormone binding .
22377122	0	amino_acid	9,19	helicase	27,35	amino acid	helicase	CHEBI:33704	164045	Chemical	Gene	START_ENTITY|nmod|domain domain|amod|END_ENTITY	A single amino_acid in the helicase domain of PMMoV-S is responsible for its enhanced accumulation in C. chinense -LRB- L -LRB- 3 -RRB- L -LRB- 3 -RRB- -RRB- plants at 32 C .
3855550	0	amino_acid	9,19	hemopexin	38,47	amino acid	hemopexin	CHEBI:33704	3263	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Complete amino_acid sequence of human hemopexin , the heme-binding protein of serum .
2704734	0	amino_acid	9,19	hexokinase	42,52	amino acid	hexokinase	CHEBI:33704	851167(Tax:4932)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Complete amino_acid sequence of rat brain hexokinase , deduced from the cloned cDNA , and proposed structure of a mammalian hexokinase .
3631958	0	amino_acid	22,32	hexokinase	10,20	amino acid	hexokinase	CHEBI:33704	851167(Tax:4932)	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|dep|sequence	Rat brain hexokinase : amino_acid sequence at the substrate hexose binding site is homologous to that of yeast hexokinase .
16911580	0	amino_acid	26,36	high_mobility_group_box_1	98,123	amino acid	high mobility group box 1	CHEBI:33704	15289(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|protein protein|amod|END_ENTITY	Stimulation of excitatory amino_acid release from adult mouse brain glia subcellular particles by high_mobility_group_box_1 protein .
18508805	0	amino_acid	9,19	histone_H4	30,40	amino acid	histone H4	CHEBI:33704	855701(Tax:4932)	Chemical	Gene	change|amod|START_ENTITY change|nmod|END_ENTITY	A single amino_acid change in histone_H4 enhances UV survival and DNA repair in yeast .
21068307	0	amino_acid	20,30	huntingtin	56,66	amino acid	huntingtin	CHEBI:33704	3064	Chemical	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Cleavage at the 586 amino_acid caspase-6 site in mutant huntingtin influences caspase-6 activation in vivo .
18459037	0	amino_acid	27,37	iNOS	57,61	amino acid	iNOS	CHEBI:33704	51477	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Identification of critical amino_acid residues for human iNOS functional activity .
10212837	0	amino_acid	60,70	insulin	12,19	amino acid	insulin	CHEBI:33704	3630	Chemical	Gene	metabolism|compound|START_ENTITY regulation|nmod|metabolism role|nmod|regulation role|nmod|hormones hormones|compound|END_ENTITY	The role of insulin and other hormones in the regulation of amino_acid and protein metabolism in humans .
11158022	0	amino_acid	47,57	insulin	13,20	amino acid	insulin	CHEBI:33704	3630	Chemical	Gene	sensitivities|nmod|START_ENTITY sensitivities|compound|END_ENTITY	Differential insulin sensitivities of glucose , amino_acid , and albumin metabolism in elderly men and women .
12937781	0	amino_acid	15,25	insulin	54,61	amino acid	insulin	CHEBI:33704	280829(Tax:9913)	Chemical	Gene	homology|amod|START_ENTITY homology|nmod|END_ENTITY	A protein with amino_acid sequence homology to bovine insulin is present in the legume Vigna_unguiculata -LRB- cowpea -RRB- .
1438163	0	amino_acid	50,60	insulin	39,46	amino acid	insulin	CHEBI:33704	3630	Chemical	Gene	replacement|amod|START_ENTITY Altering|nmod|replacement Altering|dobj|properties properties|nmod|END_ENTITY	Altering the association properties of insulin by amino_acid replacement .
1448457	0	amino_acid	29,39	insulin	65,72	amino acid	insulin	CHEBI:33704	3630	Chemical	Gene	START_ENTITY|nmod|stimulation stimulation|nmod|END_ENTITY	Contribution of postprandial amino_acid levels to stimulation of insulin , glucagon , and pancreatic_polypeptide in humans .
14620622	0	amino_acid	26,36	insulin	109,116	amino acid	insulin	CHEBI:33704	3630	Chemical	Gene	disappearance|amod|START_ENTITY disappearance|dep|feature feature|nmod|resistance resistance|compound|END_ENTITY	Impaired insulin-mediated amino_acid plasma disappearance in non-alcoholic_fatty_liver_disease : a feature of insulin resistance .
1472063	0	amino_acid	25,35	insulin	85,92	amino acid	insulin	CHEBI:33704	3630	Chemical	Gene	portion|amod|START_ENTITY important|nsubj|portion important|nmod|END_ENTITY	The carboxy terminal 110 amino_acid portion of the insulin_receptor is important for insulin signalling to pyruvate_dehydrogenase .
15064952	0	amino_acid	75,85	insulin	26,33	amino acid	insulin	CHEBI:33704	3630	Chemical	Gene	START_ENTITY|nsubj|increase increase|compound|END_ENTITY	Cell signalling-mediating insulin increase of mRNA expression for cationic amino_acid transporters-1 and -2 and membrane hyperpolarization in human umbilical vein endothelial cells .
15294054	0	amino_acid	89,99	insulin	79,86	amino acid	insulin	CHEBI:33704	3630	Chemical	Gene	skeletal|appos|START_ENTITY skeletal|acl:relcl|END_ENTITY	Regulation of protein synthesis associated with skeletal muscle_hypertrophy by insulin - , amino_acid - and exercise-induced signalling .
1542855	0	amino_acid	45,55	insulin	111,118	amino acid	insulin	CHEBI:33704	3630	Chemical	Gene	metabolism|compound|START_ENTITY action|nmod|metabolism action|dep|effects effects|nmod|END_ENTITY	Insulin action on glucose and branched-chain amino_acid metabolism in cancer_cachexia : differential effects of insulin .
15899884	0	amino_acid	27,37	insulin	59,66	amino acid	insulin	CHEBI:33704	3630	Chemical	Gene	transporter|amod|START_ENTITY regulation|nmod|transporter SNAT3|nsubj|regulation SNAT3|nmod|END_ENTITY	Differential regulation of amino_acid transporter SNAT3 by insulin in hepatocytes .
16006430	0	amino_acid	34,44	insulin	10,17	amino acid	insulin	CHEBI:33704	3630	Chemical	Gene	infusion|amod|START_ENTITY Effect|nmod|infusion Effect|nmod|END_ENTITY	Effect of insulin with concurrent amino_acid infusion on protein metabolism in rapidly growing pubertal children with type 1 diabetes .
16030064	0	amino_acid	103,113	insulin	11,18	amino acid	insulin	CHEBI:33704	3630	Chemical	Gene	stimulate|advcl|START_ENTITY stimulate|nsubj|provision provision|compound|END_ENTITY	Short-term insulin and nutritional energy provision do not stimulate muscle protein synthesis if blood amino_acid availability decreases .
16123357	0	amino_acid	86,96	insulin	50,57	amino acid	insulin	CHEBI:33704	3630	Chemical	Gene	availability|amod|START_ENTITY kinase|nmod|availability kinase|nmod|cause cause|nmod|resistance resistance|compound|END_ENTITY	Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino_acid availability .
16718465	0	amino_acid	6,16	insulin	106,113	amino acid	insulin	CHEBI:33704	3630	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|dep|effects effects|nmod|withdrawal withdrawal|compound|END_ENTITY	Renal amino_acid , fat and glucose metabolism in type 1 diabetic and non-diabetic humans : effects of acute insulin withdrawal .
1874488	0	amino_acid	29,39	insulin	10,17	amino acid	insulin	CHEBI:33704	3630	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of insulin and plasma amino_acid concentration on leucine metabolism in cirrhosis .
19724894	0	amino_acid	60,70	insulin	10,17	amino acid	insulin	CHEBI:33704	3630	Chemical	Gene	residues|amod|START_ENTITY phosphorylation|nmod|residues levels|nmod|phosphorylation levels|compound|END_ENTITY	Effect of insulin levels on the phosphorylation of specific amino_acid residues in IRS-1 : implications for burn-induced insulin resistance .
19724894	0	amino_acid	60,70	insulin	120,127	amino acid	insulin	CHEBI:33704	3630	Chemical	Gene	residues|amod|START_ENTITY phosphorylation|nmod|residues levels|nmod|phosphorylation Effect|nmod|levels Effect|dep|implications implications|nmod|resistance resistance|compound|END_ENTITY	Effect of insulin levels on the phosphorylation of specific amino_acid residues in IRS-1 : implications for burn-induced insulin resistance .
21059029	0	amino_acid	116,126	insulin	81,88	amino acid	insulin	CHEBI:33704	100060077(Tax:9796)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|addition addition|nmod|solution solution|nmod|END_ENTITY	Effects of leucine or whey protein addition to an oral glucose solution on serum insulin , plasma glucose and plasma amino_acid responses in horses at rest and following exercise .
22065088	0	amino_acid	15,25	insulin	68,75	amino acid	insulin	CHEBI:33704	3630	Chemical	Gene	levels|amod|START_ENTITY associated|nsubjpass|levels associated|nmod|improvement improvement|nmod|resistance resistance|compound|END_ENTITY	Branched-chain amino_acid levels are associated with improvement in insulin resistance with weight_loss .
2568959	0	amino_acid	59,69	insulin	144,151	amino acid	insulin	CHEBI:33704	280829(Tax:9913)	Chemical	Gene	activity|amod|START_ENTITY effects|nmod|activity effects|dep|inhibits inhibits|dep|action action|compound|END_ENTITY	Paradoxical effects of endogenous and exogenous insulin on amino_acid transport activity in the isolated rat pancreas : somatostatin-14 inhibits insulin action .
2695899	0	amino_acid	54,64	insulin	8,15	amino acid	insulin	CHEBI:33704	3630	Chemical	Gene	sequences|amod|START_ENTITY polypeptide|dep|sequences polypeptide|compound|glucagon glucagon|compound|END_ENTITY	Opossum insulin , glucagon and pancreatic polypeptide : amino_acid sequences .
2857579	0	amino_acid	37,47	insulin	10,17	amino acid	insulin	CHEBI:33704	3630	Chemical	Gene	systems|amod|START_ENTITY activity|nmod|systems Effect|nmod|activity Effect|nmod|END_ENTITY	Effect of insulin on the activity of amino_acid transport systems in cultured human fibroblasts .
3146495	0	amino_acid	51,61	insulin	103,110	amino acid	insulin	CHEBI:33704	3630	Chemical	Gene	START_ENTITY|nmod|treatment treatment|compound|END_ENTITY	Rapid changes in urinary serine and branched-chain amino_acid excretion among diabetic patients during insulin treatment .
3316280	0	amino_acid	29,39	insulin	10,17	amino acid	insulin	CHEBI:33704	3630	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of insulin and plasma amino_acid concentrations on leucine metabolism in man .
3512513	0	amino_acid	62,72	insulin	39,46	amino acid	insulin	CHEBI:33704	100760716	Chemical	Gene	transport|amod|START_ENTITY cells|compound|transport END_ENTITY|nmod|cells	A defined medium for and the effect of insulin on the growth , amino_acid transport , and morphology of Chinese_hamster ovary cells , CHO-K1 -LRB- CCL 61 -RRB- and the isolation of insulin `` independent '' mutants .
422657	0	amino_acid	24,34	insulin	58,65	amino acid	insulin	CHEBI:33704	396145(Tax:9031)	Chemical	Gene	transport|amod|START_ENTITY increase|nmod|transport modulated|nsubj|increase modulated|nmod|END_ENTITY	A transient increase in amino_acid transport modulated by insulin in differentiating muscle cells .
436747	0	amino_acid	35,45	insulin	16,23	amino acid	insulin	CHEBI:33704	396145(Tax:9031)	Chemical	Gene	binding|xcomp|START_ENTITY binding|nsubj|Relationship Relationship|nmod|END_ENTITY	Relationship of insulin binding to amino_acid transport by cultured 14-day embryonic chick heart cells .
4866431	0	amino_acid	24,34	insulin	47,54	amino acid	insulin	CHEBI:33704	280829(Tax:9913)	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Isolation and a partial amino_acid sequence of insulin from the islet tissue of cod -LRB- Gadus callarias -RRB- .
5123875	0	amino_acid	38,48	insulin	20,27	amino acid	insulin	CHEBI:33704	396145(Tax:9031)	Chemical	Gene	action|nmod|START_ENTITY action|compound|END_ENTITY	Kinetic analysis of insulin action on amino_acid uptake by isolated chick embryo heart cells .
5591761	0	amino_acid	40,50	insulin	16,23	amino acid	insulin	CHEBI:33704	3630	Chemical	Gene	metabolism|amod|START_ENTITY -LSB-|nmod|metabolism -LSB-|dobj|effects effects|nmod|END_ENTITY	-LSB- The effects of insulin and glucagon on amino_acid metabolism in the isolation perfused liver -RSB- .
5772437	0	amino_acid	50,60	insulin	39,46	amino acid	insulin	CHEBI:33704	396145(Tax:9031)	Chemical	Gene	transport|amod|START_ENTITY END_ENTITY|nmod|transport	Effect of a nerve growth factor and of insulin on amino_acid transport in the nervous system of the chick embryo .
6146554	0	amino_acid	100,110	insulin	162,169	amino acid	insulin	CHEBI:33704	102565762	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|alligator alligator|amod|END_ENTITY	Isolation and characterization of reptilian insulin , glucagon , and pancreatic_polypeptide : complete amino_acid sequence of alligator -LRB- Alligator_mississippiensis -RRB- insulin and pancreatic_polypeptide .
6146554	0	amino_acid	100,110	insulin	44,51	amino acid	insulin	CHEBI:33704	102565762	Chemical	Gene	sequence|amod|START_ENTITY Isolation|dep|sequence Isolation|nmod|END_ENTITY	Isolation and characterization of reptilian insulin , glucagon , and pancreatic_polypeptide : complete amino_acid sequence of alligator -LRB- Alligator_mississippiensis -RRB- insulin and pancreatic_polypeptide .
6149052	0	amino_acid	25,35	insulin	14,21	amino acid	insulin	CHEBI:33704	280829(Tax:9913)	Chemical	Gene	metabolism|amod|START_ENTITY END_ENTITY|nmod|metabolism	The effect of insulin on amino_acid metabolism and glycogen content in isolated liver cells of juvenile coho_salmon , Oncorhynchus_kisutch .
6341516	0	amino_acid	30,40	insulin	8,15	amino acid	insulin	CHEBI:33704	280829(Tax:9913)	Chemical	Gene	metabolism|amod|START_ENTITY regulating|dobj|metabolism END_ENTITY|acl|regulating	Role of insulin in regulating amino_acid metabolism in normal and alloxan-diabetic cattle .
6352403	0	amino_acid	35,45	insulin	11,18	amino acid	insulin	CHEBI:33704	3630	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of insulin and glucagon on amino_acid transport into the liver and opercular muscle of the eel in vitro .
6372790	0	amino_acid	55,65	insulin	13,20	amino acid	insulin	CHEBI:33704	100009181(Tax:9986)	Chemical	Gene	rate|amod|START_ENTITY regulation|nmod|rate roles|nmod|regulation roles|nmod|END_ENTITY	The roles of insulin and glucagon in the regulation of amino_acid turnover rate and pool size : in vivo study with -LSB- 15N -RSB- glycine and gas chromatography -- mass spectrometry .
6372857	0	amino_acid	24,34	insulin	73,80	amino acid	insulin	CHEBI:33704	280829(Tax:9913)	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	Critical role of the A2 amino_acid residue in the biological activity of insulin : -LSB- 2-glycine-A -RSB- - _ and _ -LSB- 2-alanine-A -RSB- insulins .
6376263	0	amino_acid	34,44	insulin	80,87	amino acid	insulin	CHEBI:33704	3630	Chemical	Gene	plasma|ccomp|START_ENTITY plasma|nsubj|glucagon glucagon|appos|concentrations concentrations|compound|END_ENTITY	Characteristic features of plasma amino_acid , plasma pancreatic glucagon , serum insulin concentrations in cirrhotic patients with histories of chronic alcohol consumption .
6439248	0	amino_acid	67,77	insulin	22,29	amino acid	insulin	CHEBI:33704	280829(Tax:9913)	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|diabetes diabetes|compound|END_ENTITY	Regulatory effects of insulin and experimental diabetes on neutral amino_acid transport in the perfused rat exocrine pancreas .
6760674	0	amino_acid	41,51	insulin	11,18	amino acid	insulin	CHEBI:33704	3630	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of insulin and glucagon on serum amino_acid concentrations in liver_disease .
698924	0	amino_acid	43,53	insulin	11,18	amino acid	insulin	CHEBI:33704	3630	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of insulin in vivo and in vitro on amino_acid transport into cells from the R3230AC mammary adenocarcinoma and their relationship to tumor growth .
7037403	0	amino_acid	14,24	insulin	5,12	amino acid	insulin	CHEBI:33704	280829(Tax:9913)	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|dep|sequence	Carp insulin : amino_acid sequence , biological activity and structural properties .
7978107	0	amino_acid	63,73	insulin	34,41	amino acid	insulin	CHEBI:33704	3630	Chemical	Gene	uptake|amod|START_ENTITY stimulated|dobj|uptake END_ENTITY|acl|stimulated	Chronic ethanol exposure inhibits insulin and IGF-1 stimulated amino_acid uptake in cultured human placental trophoblasts .
8121304	0	amino_acid	64,74	insulin	24,31	amino acid	insulin	CHEBI:33704	3630	Chemical	Gene	metabolism|amod|START_ENTITY modulating|dobj|metabolism effects|acl|modulating effects|nmod|END_ENTITY	The opposing effects of insulin and hyperglycemia in modulating amino_acid metabolism during a glucose tolerance test in lean and obese subjects .
9754734	0	amino_acid	35,45	insulin	58,65	amino acid	insulin	CHEBI:33704	3630	Chemical	Gene	solution|amod|START_ENTITY solution|nmod|secretion secretion|compound|END_ENTITY	Effects of branched-chain-enriched amino_acid solution on insulin and glucagon secretion and blood glucose level in liver cirrhosis .
9836512	0	amino_acid	27,37	insulin	114,121	amino acid	insulin	CHEBI:33704	3630	Chemical	Gene	exchange|amod|START_ENTITY regulation|nmod|exchange regulation|nmod|beds beds|nmod|END_ENTITY	Differential regulation of amino_acid exchange and protein dynamics across splanchnic_and_skeletal_muscle beds by insulin in healthy human subjects .
632300	0	amino_acid	4,14	insulin-like_growth_factor_I	33,61	amino acid	insulin-like growth factor I	CHEBI:33704	3479	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The amino_acid sequence of human insulin-like_growth_factor_I and its structural homology with proinsulin .
2318937	0	amino_acid	4,14	insulin_receptor	31,47	amino acid	insulin receptor	CHEBI:33704	3643	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The amino_acid sequence of the insulin_receptor is normal in an insulin-resistant Pima Indian .
8521812	0	amino_acid	9,19	integrin_alpha_4	125,141	amino acid	integrin alpha 4	CHEBI:33704	3676	Chemical	Gene	residues|amod|START_ENTITY clustered|nsubjpass|residues clustered|nmod|beta-turn beta-turn|nmod|repeat repeat|nmod|END_ENTITY	Critical amino_acid residues for ligand binding are clustered in a predicted beta-turn of the third N-terminal repeat in the integrin_alpha_4 and alpha 5 subunits .
1386253	0	amino_acid	9,19	interleukin-1_beta	136,154	amino acid	interleukin-1 beta	CHEBI:33704	3553	Chemical	Gene	substitutions|amod|START_ENTITY suggest|nsubj|substitutions suggest|xcomp|binding binding|nmod|protein protein|amod|END_ENTITY	Multiple amino_acid substitutions suggest a structural basis for the separation of biological activity and receptor binding in a mutant interleukin-1_beta protein .
8028504	0	amino_acid	101,111	interleukin-1_beta	36,54	amino acid	interleukin-1 beta	CHEBI:33704	24494(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY END_ENTITY|nmod|metabolism	Independent and combined actions of interleukin-1_beta , tumor_necrosis_factor_alpha , and glucagon on amino_acid metabolism in the isolated perfused rat liver .
8651752	0	amino_acid	134,144	interleukin-6	105,118	amino acid	interleukin-6	CHEBI:33704	3569	Chemical	Gene	transport|amod|START_ENTITY stimulation|nmod|transport stimulation|amod|END_ENTITY	Glucocorticoid-dependent induction of interleukin-6_receptor expression in human hepatocytes facilitates interleukin-6 stimulation of amino_acid transport .
1511016	0	amino_acid	23,33	lactoferrin	54,65	amino acid	lactoferrin	CHEBI:33704	17002(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Nucleotide and primary amino_acid sequence of porcine lactoferrin .
6510420	0	amino_acid	24,34	lactotransferrin	6,22	amino acid	lactotransferrin	CHEBI:33704	4057	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|dep|sequence	Human lactotransferrin : amino_acid sequence and structural comparisons with other transferrins .
1997398	0	amino_acid	21,31	laminin_A_chain	48,63	amino acid	laminin A chain	CHEBI:33704	16772(Tax:10090)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Identification of an amino_acid sequence in the laminin_A_chain mediating mast cell attachment and spreading .
2156266	0	amino_acid	21,31	laminin_A_chain	50,65	amino acid	laminin A chain	CHEBI:33704	16772(Tax:10090)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Identification of an amino_acid sequence from the laminin_A_chain that stimulates metastasis and collagenase IV production .
20609473	0	amino_acid	10,20	leptin	45,51	amino acid	leptin	D000596	3952	Chemical	Gene	START_ENTITY|dobj|resistance resistance|compound|END_ENTITY	Placental amino_acid transport and placental leptin resistance in pregnancies complicated by maternal obesity .
2777088	0	amino_acid	110,120	lipoxygenase	149,161	amino acid	lipoxygenase	CHEBI:33704	100009114(Tax:9986)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The complete sequence of the rabbit erythroid_cell-specific_15-lipoxygenase mRNA : comparison of the predicted amino_acid sequence of the erythrocyte lipoxygenase with other lipoxygenases .
1368712	0	amino_acid	4,14	lysozyme	27,35	amino acid	lysozyme	CHEBI:33704	4069	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|pheasant pheasant|amod|END_ENTITY	The amino_acid sequence of lysozyme from kalij pheasant -LRB- Lophura leucomelana -RRB- egg-white .
14730141	0	amino_acid	4,14	lysozyme	42,50	amino acid	lysozyme	CHEBI:33704	100547044	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The amino_acid sequence of satyr tragopan lysozyme and its activity .
23252580	0	amino_acid	147,157	lysozyme	25,33	amino acid	lysozyme	CHEBI:33704	781146(Tax:9913)	Chemical	Gene	residues|amod|START_ENTITY role|nmod|residues modification|dep|role modification|nmod|and_bovine_eye_lens_proteins and_bovine_eye_lens_proteins|amod|_ _|amod|END_ENTITY	Chemical modification of lysozyme , glucose_6-phosphate_dehydrogenase , _ and_bovine_eye_lens_proteins induced by peroxyl radicals : role of oxidizable amino_acid residues .
9532789	0	amino_acid	31,41	lysozyme	74,82	amino acid	lysozyme	CHEBI:33704	4069	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Reptile lysozyme : the complete amino_acid sequence of soft-shelled turtle lysozyme and its activity .
9532789	0	amino_acid	31,41	lysozyme	8,16	amino acid	lysozyme	CHEBI:33704	4069	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|dep|sequence	Reptile lysozyme : the complete amino_acid sequence of soft-shelled turtle lysozyme and its activity .
7823015	0	amino_acid	19,29	mCAT	74,78	amino acid	mCAT	CHEBI:33704	12359(Tax:10090)	Chemical	Gene	transport|amod|START_ENTITY type|dep|transport y|dep|type y|dep|expression expression|nmod|genes genes|amod|END_ENTITY	y -LRB- + -RRB- - type cationic amino_acid transport : expression and regulation of the mCAT genes .
7865544	0	amino_acid	69,79	mCAT	93,97	amino acid	mCAT	CHEBI:33704	12359(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Multiple components of transport are associated with murine cationic amino_acid transporter -LRB- mCAT -RRB- expression in Xenopus oocytes .
12537539	0	amino_acid	15,25	mNAT3	39,44	amino acid	mNAT3	CHEBI:33704	17962(Tax:10090)	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Mouse system-N amino_acid transporter , mNAT3 , expressed in hepatocytes and regulated by insulin-activated and phosphoinositide 3-kinase-dependent signalling .
12617835	0	amino_acid	40,50	mOb1	14,18	amino acid	mOb1	CHEBI:33704	74318(Tax:10090)	Chemical	Gene	Expression|acl|START_ENTITY Expression|nmod|END_ENTITY	Expression of mOb1 , a novel atypical 73 amino_acid K50-homeodomain protein , during mouse development .
14516659	0	amino_acid	40,50	mOb1	14,18	amino acid	mOb1	CHEBI:33704	74318(Tax:10090)	Chemical	Gene	Expression|acl|START_ENTITY Expression|nmod|END_ENTITY	Expression of mOb1 , a novel atypical 73 amino_acid K50-homeodomain protein , during mouse development .
18056791	0	amino_acid	27,37	mTOR	104,108	amino acid	mTOR	CHEBI:33704	21977(Tax:10090)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|signaling signaling|compound|END_ENTITY	Leucine-enriched essential amino_acid and carbohydrate ingestion following resistance exercise enhances mTOR signaling and protein synthesis in human muscle .
20016704	0	amino_acid	14,24	mTOR	36,40	amino acid	mTOR	CHEBI:33704	21977(Tax:10090)	Chemical	Gene	sensing|amod|START_ENTITY sensing|nmod|END_ENTITY	Mechanisms of amino_acid sensing in mTOR signaling pathway .
23031788	0	amino_acid	38,48	mTOR	18,22	amino acid	mTOR	CHEBI:33704	21977(Tax:10090)	Chemical	Gene	pathway|nmod|START_ENTITY pathway|compound|END_ENTITY	Activation of the mTOR pathway by the amino_acid -LRB- L -RRB- - leucine in the 5q - _ syndrome and other ribosomopathies .
18497260	0	amino_acid	40,50	mTORC1	64,70	amino acid	mTORC1	CHEBI:33704	382056(Tax:10090)	Chemical	Gene	START_ENTITY|xcomp|signaling signaling|nmod|END_ENTITY	The Rag GTPases bind raptor and mediate amino_acid signaling to mTORC1 .
19203575	0	amino_acid	3,13	mTORC1	32,38	amino acid	mTORC1	CHEBI:33704	382056(Tax:10090)	Chemical	Gene	shuffle|amod|START_ENTITY activates|nsubj|shuffle activates|dobj|END_ENTITY	An amino_acid shuffle activates mTORC1 .
21403644	0	amino_acid	8,18	mTORC1	57,63	amino acid	mTORC1	CHEBI:33704	382056(Tax:10090)	Chemical	Gene	LAT2|amod|START_ENTITY Role|nmod|LAT2 Role|nmod|activation activation|nmod|pathway pathway|amod|END_ENTITY	Role of amino_acid transporter LAT2 in the activation of mTORC1 pathway and the pathogenesis of crescentic glomerulonephritis .
22643846	0	amino_acid	13,23	mTORC1	49,55	amino acid	mTORC1	CHEBI:33704	382056(Tax:10090)	Chemical	Gene	transporters|amod|START_ENTITY transporters|acl|involved involved|nmod|activation activation|amod|END_ENTITY	Abundance of amino_acid transporters involved in mTORC1 activation in skeletal muscle of neonatal pigs is developmentally regulated .
22980980	0	amino_acid	51,61	mTORC1	72,78	amino acid	mTORC1	CHEBI:33704	382056(Tax:10090)	Chemical	Gene	levels|amod|START_ENTITY signal|dobj|levels signal|nmod|END_ENTITY	Ragulator is a GEF for the rag GTPases that signal amino_acid levels to mTORC1 .
23103253	0	amino_acid	46,56	mTORC1	17,23	amino acid	mTORC1	CHEBI:33704	382056(Tax:10090)	Chemical	Gene	SLC7A5|amod|START_ENTITY acts|nmod|SLC7A5 acts|nmod|activator activator|amod|END_ENTITY	HIF2a acts as an mTORC1 activator through the amino_acid carrier SLC7A5 .
24095279	0	amino_acid	76,86	mTORC1	97,103	amino acid	mTORC1	CHEBI:33704	382056(Tax:10090)	Chemical	Gene	levels|amod|START_ENTITY signal|dobj|levels signal|nmod|END_ENTITY	The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino_acid levels to mTORC1 .
24476474	0	amino_acid	35,45	mTORC1	79,85	amino acid	mTORC1	CHEBI:33704	382056(Tax:10090)	Chemical	Gene	supplement|amod|START_ENTITY leucine|nmod|supplement Absence|nmod|leucine reduces|nsubj|Absence reduces|dobj|activation activation|nmod|signalling signalling|amod|END_ENTITY	Absence of leucine in an essential amino_acid supplement reduces activation of mTORC1 signalling following resistance exercise in young females .
25561175	0	amino_acid	40,50	mTORC1	83,89	amino acid	mTORC1	D000596	382056(Tax:10090)	Chemical	Gene	machinery|amod|START_ENTITY machinery|acl:relcl|controls controls|dobj|END_ENTITY	SLC38A9 is a component of the lysosomal amino_acid sensing machinery that controls mTORC1 .
25567906	1	amino_acid	22,32	mTORC1	85,91	amino acid	mTORC1	CHEBI:33704	382056(Tax:10090)	Chemical	Gene	signals|amod|START_ENTITY arginine|nsubj|signals arginine|nmod|END_ENTITY	Lysosomal amino_acid transporter SLC38A9 signals arginine sufficiency to mTORC1 .
26101697	0	amino_acid	7,17	mTORC1	54,60	amino acid	mTORC1	D000596	382056(Tax:10090)	Chemical	Gene	START_ENTITY|parataxis|targeting targeting|dobj|pathway pathway|amod|END_ENTITY	L-type amino_acid transport and cancer : targeting the mTORC1 pathway to inhibit neoplasia .
26308575	0	amino_acid	9,19	mTORC1	128,134	amino acid	mTORC1	D000596	382056(Tax:10090)	Chemical	Gene	START_ENTITY|xcomp|signaling signaling|nmod|activation activation|nmod|END_ENTITY	Aberrant amino_acid signaling promotes growth and metastasis of hepatocellular_carcinomas through Rab1A-dependent activation of mTORC1 by Rab1A .
26543160	0	amino_acid	38,48	mTORC1	14,20	amino acid	mTORC1	D000596	382056(Tax:10090)	Chemical	Gene	deprivation|amod|START_ENTITY sustains|nmod|deprivation sustains|dobj|suppression suppression|amod|END_ENTITY	GCN2 sustains mTORC1 suppression upon amino_acid deprivation by inducing Sestrin2 .
26611634	0	amino_acid	74,84	mTORC1	98,104	amino acid	mTORC1	D000596	382056(Tax:10090)	Chemical	Gene	START_ENTITY|xcomp|signaling signaling|nmod|END_ENTITY	The Hippo pathway effectors YAP and TAZ promote cell growth by modulating amino_acid signaling to mTORC1 .
26658722	0	amino_acid	9,19	mTORC1	38,44	amino acid	mTORC1	D000596	382056(Tax:10090)	Chemical	Gene	START_ENTITY|xcomp|sensing sensing|nmod|END_ENTITY	Multiple amino_acid sensing inputs to mTORC1 .
27047741	0	amino_acid	55,65	mTORC1	0,6	amino acid	mTORC1	D000596	382056(Tax:10090)	Chemical	Gene	catabolism|amod|START_ENTITY regulation|nmod|catabolism involved|nmod|regulation involved|nsubjpass|END_ENTITY	mTORC1 is involved in the regulation of branched-chain amino_acid catabolism in mouse heart .
2373168	0	amino_acid	8,18	major_intrinsic_protein	35,58	amino acid	major intrinsic protein	CHEBI:33704	374124(Tax:9031)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Partial amino_acid sequence of the major_intrinsic_protein -LRB- MIP -RRB- of the chicken lens deduced from the nucleotide sequence of a cDNA clone .
1686347	0	amino_acid	17,27	matrix_gla_protein	46,64	amino acid	matrix gla protein	CHEBI:33704	17313(Tax:10090)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	cDNA and deduced amino_acid sequence of mouse matrix_gla_protein : one of five glutamic_acid residues potentially modified to gla is not conserved in the mouse sequence .
18955490	0	amino_acid	18,28	matrix_metalloproteinase-7	41,67	amino acid	matrix metalloproteinase-7	CHEBI:33704	4316	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Identification of amino_acid residues of matrix_metalloproteinase-7 essential for binding to cholesterol_sulfate .
7608189	1	amino_acid	134,144	mercaptopyruvate_sulfurtransferase	178,212	amino acid	mercaptopyruvate sulfurtransferase	CHEBI:33704	192172(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Striking similarity in active site amino_acid sequence and the increase in the mercaptopyruvate_sulfurtransferase activity of rhodanese by site-directed mutagenesis .
8910318	0	amino_acid	8,18	mercaptopyruvate_sulfurtransferase	60,94	amino acid	mercaptopyruvate sulfurtransferase	CHEBI:33704	192172(Tax:10116)	Chemical	Gene	residues|amod|START_ENTITY Role|nmod|residues END_ENTITY|nsubj|Role	Role of amino_acid residues in the active site of rat liver mercaptopyruvate_sulfurtransferase .
914867	1	amino_acid	39,49	metallothionein-I	62,79	amino acid	metallothionein-I	CHEBI:33704	17748(Tax:10090)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Complete amino_acid sequence of metallothionein-I .
7287658	0	amino_acid	9,19	metallothionein-II	44,62	amino acid	metallothionein-II	CHEBI:33704	17750(Tax:10090)	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|nsubj|sequence	Complete amino_acid sequence of mouse liver metallothionein-II .
23373973	0	amino_acid	47,57	miR-122	10,17	amino acid	miR-122	CHEBI:33704	406906	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of miR-122 and its target gene cationic amino_acid transporter 1 on colorectal_liver_metastasis .
3038520	0	amino_acid	13,23	mitochondrial_3-oxoacyl-CoA_thiolase	40,76	amino acid	mitochondrial 3-oxoacyl-CoA thiolase	CHEBI:33704	170465(Tax:10116)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	cDNA-derived amino_acid sequence of rat mitochondrial_3-oxoacyl-CoA_thiolase with no transient presequence : structural relationship with peroxisomal isozyme .
9162023	0	amino_acid	6,16	monoamine_oxidase_A_and_B	58,83	amino acid	monoamine oxidase A and B	CHEBI:33704	29253;25750	Chemical	Gene	START_ENTITY|nmod|selectivity selectivity|nmod|END_ENTITY	A key amino_acid responsible for substrate selectivity of monoamine_oxidase_A_and_B .
18761781	0	amino_acid	43,53	mucin	22,27	amino acid	mucin	CHEBI:33704	423101(Tax:9031)	Chemical	Gene	START_ENTITY|nsubj|increases increases|amod|END_ENTITY	Phytic_acid increases mucin and endogenous amino_acid losses from the gastrointestinal tract of chickens .
11278596	0	amino_acid	21,31	multidrug_resistance_protein_1	43,73	amino acid	multidrug resistance protein 1	CHEBI:33704	4363	Chemical	Gene	residue|amod|START_ENTITY residue|nmod|END_ENTITY	Identification of an amino_acid residue in multidrug_resistance_protein_1 critical for conferring resistance to anthracyclines .
11429411	0	amino_acid	33,43	multidrug_resistance_protein_1	55,85	amino acid	multidrug resistance protein 1	CHEBI:33704	18669(Tax:10090)	Chemical	Gene	residue|amod|START_ENTITY residue|nmod|END_ENTITY	Identification of a nonconserved amino_acid residue in multidrug_resistance_protein_1 important for determining substrate specificity : evidence for functional interaction between transmembrane helices 14 and 17 .
6096363	0	amino_acid	22,32	muscle_creatine_kinase	51,73	amino acid	muscle creatine kinase	CHEBI:33704	100009056(Tax:9986)	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|nsubj|sequence	Complete cDNA-derived amino_acid sequence of chick muscle_creatine_kinase .
1696624	0	amino_acid	28,38	myelin_basic_protein	6,26	amino acid	myelin basic protein	CHEBI:33704	618684(Tax:9913)	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|dep|sequence	Shark myelin_basic_protein : amino_acid sequence , secondary structure , and self-association .
1202228	0	amino_acid	4,14	myoglobin	27,36	amino acid	myoglobin	CHEBI:33704	780509(Tax:9940)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The amino_acid sequence of myoglobin from skeletal muscles of red_deer -LRB- Cervus_elaphus -RRB- .
4153103	0	amino_acid	4,14	myoglobin	33,42	amino acid	myoglobin	CHEBI:33704	4151	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The amino_acid sequence of human myoglobin and its minor fractions .
454657	0	amino_acid	9,19	myoglobin	36,45	amino acid	myoglobin	CHEBI:33704	101315962	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Complete amino_acid sequence of the myoglobin from the Pacific spotted dolphin , Stenella_attenuata graffmani .
656376	0	amino_acid	9,19	myoglobin	32,41	amino acid	myoglobin	CHEBI:33704	101315962	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Complete amino_acid sequence of myoglobin from the pilot whale , Globicephala melaena .
6774758	0	amino_acid	4,14	myoglobin	66,75	amino acid	myoglobin	CHEBI:33704	102569755	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|nsubj|sequence	The amino_acid sequence of alligator -LRB- Alligator_mississippiensis -RRB- myoglobin .
974068	0	amino_acid	9,19	myoglobin	36,45	amino acid	myoglobin	CHEBI:33704	101315962	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Complete amino_acid sequence of the myoglobin from the Atlantic bottlenosed_dolphin , Tursiops_truncatus .
10820029	0	amino_acid	31,41	myosin	80,86	amino acid	myosin	CHEBI:33704	79784	Chemical	Gene	modulates|amod|START_ENTITY function|nsubj|modulates function|nmod|IIA IIA|compound|END_ENTITY	A conserved negatively charged amino_acid modulates function in human nonmuscle myosin IIA .
11886898	1	amino_acid	160,170	myosin	71,77	amino acid	myosin	CHEBI:33704	395534(Tax:9031)	Chemical	Gene	residues|amod|START_ENTITY described|nmod|residues myosin|acl|described myosin|nsubj|chain chain|compound|END_ENTITY	Hamy3 , a novel type myosin heavy chain from sunflower is the smallest myosin described so far , with only 900 amino_acid residues .
132431	2	amino_acid	64,74	myosin	86,92	amino acid	myosin	CHEBI:33704	79784	Chemical	Gene	residue|amod|START_ENTITY residue|nmod|END_ENTITY	Spectrophotometric identification of the amino_acid residue of myosin modified by rho-nitrobenzenediazonium_fluoroborate .
2982157	0	amino_acid	162,172	myosin	98,104	amino acid	myosin	CHEBI:33704	43323(Tax:7227)	Chemical	Gene	sequences|amod|START_ENTITY result|nmod|sequences alkali|dobj|result alkali|nsubj|variations variations|nmod|pattern pattern|nmod|transcripts transcripts|nmod|END_ENTITY	Developmental variations in the splicing pattern of transcripts from the Drosophila gene encoding myosin alkali light chain result in different carboxyl-terminal amino_acid sequences .
3497920	0	amino_acid	50,60	myosin	106,112	amino acid	myosin	CHEBI:33704	79784	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|residue residue|nmod|END_ENTITY	F-actin-binding synthetic heptapeptide having the amino_acid sequence around the SH1 cysteinyl residue of myosin .
3972832	0	amino_acid	4,14	myosin	73,79	amino acid	myosin	CHEBI:33704	79784	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|region region|nmod|END_ENTITY	The amino_acid sequence and stability predictions of the hinge region in myosin subfragment 2 .
6328279	0	amino_acid	110,120	myosin	150,156	amino acid	myosin	CHEBI:33704	395534(Tax:9031)	Chemical	Gene	homology|amod|START_ENTITY homology|nmod|chains chains|compound|END_ENTITY	Drosophila_melanogaster has only one myosin_alkali_light-chain gene which encodes a protein with considerable amino_acid sequence homology to chicken myosin alkali light chains .
7309700	0	amino_acid	14,24	myosin	84,90	amino acid	myosin	CHEBI:33704	79784	Chemical	Gene	composition|amod|START_ENTITY Properties|nmod|composition Properties|nmod|fragments fragments|nmod|chain chain|nmod|subfragment-1 subfragment-1|compound|END_ENTITY	Properties of amino_acid composition of the tryptic fragments of the heavy chain of myosin subfragment-1 .
7622596	4	amino_acid	474,484	myosin	531,537	amino acid	myosin	CHEBI:33704	79784	Chemical	Gene	sequence|amod|START_ENTITY Analysis|nmod|sequence reveals|nsubj|Analysis reveals|ccomp|encodes encodes|dobj|END_ENTITY	Analysis of the deduced amino_acid sequence reveals that the myoC gene encodes a myosin that is homologous to the well-described Acanthamoeba myosin Is as well as to Dictyostelium myoB and - D .
8421702	0	amino_acid	84,94	myosin	27,33	amino acid	myosin	CHEBI:33704	79784	Chemical	Gene	sequences|amod|START_ENTITY comparisons|nmod|sequences derived|nmod|comparisons relationships|acl|derived evolution|dep|relationships evolution|nmod|family family|compound|END_ENTITY	Molecular evolution of the myosin family : relationships derived from comparisons of amino_acid sequences .
9748336	0	amino_acid	11,21	myosin	134,140	amino acid	myosin	CHEBI:33704	79784	Chemical	Gene	sequence|amod|START_ENTITY critical|nsubj|sequence critical|nmod|regulation regulation|nmod|END_ENTITY	A specific amino_acid sequence at the head-rod junction is not critical for the phosphorylation-dependent regulation of smooth muscle myosin .
9172081	0	amino_acid	4,14	myosin_IC	59,68	amino acid	myosin IC	CHEBI:33704	4641	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The amino_acid sequence of the light chain of Acanthamoeba myosin_IC .
9868543	0	amino_acid	23,33	myosin_binding_protein_H	51,75	amino acid	myosin binding protein H	CHEBI:33704	83708(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|sequences sequences|nmod|END_ENTITY	Nucleotide and deduced amino_acid sequences of rat myosin_binding_protein_H -LRB- MyBP-H -RRB- .
8508536	5	amino_acid	916,926	myotrophin	945,955	amino acid	myotrophin	CHEBI:33704	79215(Tax:10116)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The partial internal amino_acid sequence of human myotrophin is very similar to that of rat myotrophin peptide T9 .
24950454	0	amino_acid	61,71	nAChR	145,150	amino acid	nAChR	CHEBI:33704	1137	Chemical	Gene	residue|amod|START_ENTITY residue|nmod|END_ENTITY	Two rare variations , D478N and D478E , that occur at the same amino_acid residue in nicotinic_acetylcholine_receptor -LRB- nAChR -RRB- a2 subunit influence nAChR function .
1247508	0	amino_acid	44,54	nerve_growth_factor	67,86	amino acid	nerve growth factor	CHEBI:33704	18049(Tax:10090)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Purification , characterization , and partial amino_acid sequence of nerve_growth_factor from cobra venom .
3920075	0	amino_acid	13,23	neurofilament_protein	56,77	amino acid	neurofilament protein	CHEBI:33704	4747	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The complete amino_acid sequence of the major mammalian neurofilament_protein -LRB- NF-L -RRB- .
2041484	0	amino_acid	29,39	neuroleukin	52,63	amino acid	neuroleukin	CHEBI:33704	2821	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Are syntax errors due to the amino_acid sequence of neuroleukin involved in the pathogenesis of the acquired_immunodeficiency_syndrome -LRB- AIDS -RRB- and insulin_dependent_diabetes_mellitus -LRB- IDDM -RRB- ?
3208766	0	amino_acid	9,19	neurone-specific_gamma_isozyme_of_enolase	36,77	amino acid	neurone-specific gamma isozyme of enolase	CHEBI:33704	2026	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Complete amino_acid sequence of the neurone-specific_gamma_isozyme_of_enolase -LRB- NSE -RRB- from human brain and comparison with the non-neuronal alpha form -LRB- NNE -RRB- .
711731	0	amino_acid	4,14	neurotensin	48,59	amino acid	neurotensin	CHEBI:33704	280881(Tax:9913)	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|nsubj|sequence	The amino_acid sequence of radioimmunoassayable neurotensin from bovine intestine .
1420572	0	amino_acid	13,23	neurotoxin	69,79	amino acid	neurotoxin	CHEBI:33704	20490862	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The complete amino_acid sequence of the Clostridium_botulinum type D neurotoxin , deduced by nucleotide sequence analysis of the encoding phage d-16 phi genome .
1915369	0	amino_acid	81,91	non-specific_lipid-transfer_protein	114,149	amino acid	non-specific lipid-transfer protein	CHEBI:33704	25541(Tax:10116)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Identification of the cDNA clone which encodes the 58-kDa protein containing the amino_acid sequence of rat liver non-specific_lipid-transfer_protein -LRB- sterol-carrier_protein_2 -RRB- .
2334427	0	amino_acid	4,14	non-specific_lipid_transfer_protein	37,72	amino acid	non-specific lipid transfer protein	CHEBI:33704	25541(Tax:10116)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The amino_acid sequence of rat liver non-specific_lipid_transfer_protein -LRB- sterol_carrier_protein_2 -RRB- is present in a high molecular weight protein : evidence from cDNA analysis .
2034675	0	amino_acid	30,40	nonspecific_lipid_transfer_protein	53,87	amino acid	nonspecific lipid transfer protein	CHEBI:33704	25541(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Molecular cloning and deduced amino_acid sequence of nonspecific_lipid_transfer_protein -LRB- sterol_carrier_protein_2 -RRB- of rat liver : a higher molecular mass -LRB- 60 kDa -RRB- protein contains the primary sequence of nonspecific_lipid_transfer_protein as its C-terminal part .
2219702	0	amino_acid	5,15	nsP1	27,31	amino acid	nsP1	CHEBI:33704	10045	Chemical	Gene	changes|amod|START_ENTITY changes|nmod|END_ENTITY	Both amino_acid changes in nsP1 of Sindbis_virusLM21 contribute to and are required for efficient expression of the mutant phenotype .
2229004	0	amino_acid	9,19	ornithine_aminotransferase	43,69	amino acid	ornithine aminotransferase	CHEBI:33704	64313(Tax:10116)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Complete amino_acid sequence of rat kidney ornithine_aminotransferase : identity with liver ornithine_aminotransferase .
3595418	0	amino_acid	9,19	ornithine_decarboxylase	38,61	amino acid	ornithine decarboxylase	CHEBI:33704	4953	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Complete amino_acid sequence of human ornithine_decarboxylase deduced from complementary DNA .
11793483	0	amino_acid	114,124	ornithine_transcarbamylase	154,180	amino acid	ornithine transcarbamylase	CHEBI:33704	5009	Chemical	Gene	START_ENTITY|nmod|gene gene|nmod|END_ENTITY	Identification of seven novel missense mutations , two splice-site mutations , two microdeletions and a polymorphic amino_acid substitution in the gene for ornithine_transcarbamylase -LRB- OTC -RRB- in patients with OTC_deficiency .
7914668	0	amino_acid	9,19	ornithine_transcarbamylase	85,111	amino acid	ornithine transcarbamylase	CHEBI:33704	18416(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|deficiency deficiency|compound|END_ENTITY	Regional amino_acid neurotransmitter changes in brains of spf/Y mice with congenital ornithine_transcarbamylase deficiency .
2547759	0	amino_acid	25,35	osteogenin	48,58	amino acid	osteogenin	CHEBI:33704	539527(Tax:9913)	Chemical	Gene	sequence|compound|START_ENTITY sequence|nmod|END_ENTITY	Purification and partial amino_acid sequence of osteogenin , a protein initiating bone differentiation .
10410246	0	amino_acid	4,14	ovocleidin_17	27,40	amino acid	ovocleidin 17	CHEBI:33704	100313508(Tax:9031)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The amino_acid sequence of ovocleidin_17 , a major protein of the avian eggshell calcified layer .
3745445	3	amino_acid	385,395	oxytocin	407,415	amino acid	oxytocin	CHEBI:33704	5020	Chemical	Gene	residue|amod|START_ENTITY residue|nmod|END_ENTITY	Amino-Butyl-Ethyl-Isoluminol -LRB- ABEI -RRB- was attached to the alpha-amino function of the N-terminal amino_acid residue of oxytocin ; this complex was used in immunoassays for oxytocin .
9177475	0	amino_acid	13,23	oxytocinase	52,63	amino acid	oxytocinase	CHEBI:33704	4012	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|nsubj|sequence	The complete amino_acid sequence of human placental oxytocinase .
6313426	0	amino_acid	9,19	p15	79,82	amino acid	p15	CHEBI:33704	1030	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Complete amino_acid sequence of human T-cell_leukemia_virus structural protein p15 .
9645195	0	amino_acid	29,39	p17	52,55	amino acid	p17	CHEBI:33704	653820	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|protein protein|amod|END_ENTITY	Slight difference in primary amino_acid sequence of p17 matrix protein of HIV-1 exerts profound influence on its antigenicity .
1810347	0	amino_acid	11,21	p21	62,65	amino acid	p21	CHEBI:33704	644914	Chemical	Gene	START_ENTITY|dobj|distribution distribution|nmod|END_ENTITY	` Hot spot ' amino_acid distribution in Ha-ras oncogene product p21 : relationship to guanine binding site .
3547088	0	amino_acid	34,44	p53	65,68	amino acid	p53	CHEBI:33704	7157	Chemical	Gene	residue|amod|START_ENTITY residue|nmod|END_ENTITY	Primary structure polymorphism at amino_acid residue 72 of human p53 .
6400059	0	amino_acid	4,14	p53	34,37	amino acid	p53	CHEBI:33704	22060(Tax:10090)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The amino_acid sequence of murine p53 determined from a c-DNA clone .
1731189	0	amino_acid	79,89	pIgA	49,53	amino acid	pIgA	CHEBI:33704	18700(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|protein protein|compound|END_ENTITY	Binding of secretory component to protein 511 , a pIgA mouse protein lacking 36 amino_acid residues of the C_alpha_3 domain .
1900491	0	amino_acid	88,98	pancreatic_polypeptide	10,32	amino acid	pancreatic polypeptide	CHEBI:33704	5539	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of pancreatic_polypeptide , thyrotropin-releasing_hormone , and glucagon on plasma amino_acid uptake by human pancreas .
556267	0	amino_acid	4,14	pancreatic_ribonuclease	33,56	amino acid	pancreatic ribonuclease	CHEBI:33704	497071(Tax:10090)	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|nsubj|sequence	The amino_acid sequence of mouse pancreatic_ribonuclease .
3541906	0	amino_acid	8,18	pancreatic_stone_protein	37,61	amino acid	pancreatic stone protein	CHEBI:33704	5967	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Partial amino_acid sequence of human pancreatic_stone_protein , a novel pancreatic secretory protein .
3421960	0	amino_acid	21,31	parathymosin	65,77	amino acid	parathymosin	CHEBI:33704	83801(Tax:10116)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Bovine parathymosin : amino_acid sequence and comparison with rat parathymosin .
3421960	0	amino_acid	21,31	parathymosin	7,19	amino acid	parathymosin	CHEBI:33704	83801(Tax:10116)	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|dep|sequence	Bovine parathymosin : amino_acid sequence and comparison with rat parathymosin .
16923805	0	amino_acid	8,18	parathyroid_hormone	50,69	amino acid	parathyroid hormone	CHEBI:33704	5741	Chemical	Gene	chains|amod|START_ENTITY Role|nmod|chains Role|nmod|END_ENTITY	Role of amino_acid side chains in region 17-31 of parathyroid_hormone -LRB- PTH -RRB- in binding to the PTH_receptor .
2850726	0	amino_acid	33,43	parathyroid_hormone	10,29	amino acid	parathyroid hormone	CHEBI:33704	19226(Tax:10090)	Chemical	Gene	transport|amod|START_ENTITY END_ENTITY|nmod|transport	Effect of parathyroid_hormone on amino_acid transport by cultured neonatal mouse calvarial bone cells .
5275384	0	amino_acid	28,38	parathyroid_hormone	7,26	amino acid	parathyroid hormone	CHEBI:33704	280903(Tax:9913)	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|dep|sequence	Bovine parathyroid_hormone : amino_acid sequence .
7185060	0	amino_acid	59,69	parathyroid_hormone	36,55	amino acid	parathyroid hormone	CHEBI:33704	100351309(Tax:9986)	Chemical	Gene	transport|amod|START_ENTITY Effect|nmod|transport Effect|nmod|END_ENTITY	Effect of in vivo administration of parathyroid_hormone on amino_acid transport in membrane vesicles prepared from rabbit kidney tubules .
8940381	0	amino_acid	10,20	parathyroid_hormone	35,54	amino acid	parathyroid hormone	CHEBI:33704	5741	Chemical	Gene	region|amod|START_ENTITY region|nmod|molecule molecule|amod|END_ENTITY	The 69-84 amino_acid region of the parathyroid_hormone molecule is essential for the interaction of the hormone with the binding sites with carboxyl-terminal specificity .
10788779	0	amino_acid	35,45	parvalbumin	23,34	amino acid	parvalbumin	CHEBI:33704	5816	Chemical	Gene	START_ENTITY|nsubj|determination determination|nmod|END_ENTITY	Rapid determination of parvalbumin amino_acid sequence from Rana catesbeiana -LRB- pI 4.78 -RRB- by combination of ESI mass spectrometry , protein sequencing , and amino_acid analysis .
2384163	0	amino_acid	13,23	parvalbumin	64,75	amino acid	parvalbumin	CHEBI:33704	5816	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|nsubj|sequence	The complete amino_acid sequence of bullfrog -LRB- Rana catesbeiana -RRB- parvalbumin pI4 .97 .
2752733	0	amino_acid	4,14	parvalbumin	31,42	amino acid	parvalbumin	CHEBI:33704	5816	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The amino_acid sequence of the parvalbumin from the very fast swimbladder muscle of the toadfish -LRB- Opsanus tau -RRB- .
17242376	0	amino_acid	27,37	paxillin	49,57	amino acid	paxillin	CHEBI:33704	5829	Chemical	Gene	mutants|amod|START_ENTITY mutants|nmod|END_ENTITY	Semisynthesis of unnatural amino_acid mutants of paxillin : protein probes for cell migration studies .
15528269	0	amino_acid	48,58	peripheral-type_benzodiazepine_receptor	85,124	amino acid	peripheral-type benzodiazepine receptor	D000596	706	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Characterization of the cholesterol recognition amino_acid consensus sequence of the peripheral-type_benzodiazepine_receptor .
8396932	0	amino_acid	25,35	peroxidase	101,111	amino acid	peroxidase	CHEBI:33704	547504(Tax:3847)	Chemical	Gene	sequence|compound|START_ENTITY sequence|nmod|END_ENTITY	Purification and partial amino_acid sequence of a wound-inducible , developmentally regulated anionic peroxidase from soybean leaves .
7565638	0	amino_acid	9,19	peroxisome_proliferator-activated_receptor_alpha	40,88	amino acid	peroxisome proliferator-activated receptor alpha	CHEBI:33704	19013(Tax:10090)	Chemical	Gene	change|amod|START_ENTITY change|nmod|END_ENTITY	A single amino_acid change in the mouse peroxisome_proliferator-activated_receptor_alpha alters transcriptional responses to peroxisome proliferators .
26046374	0	amino_acid	146,156	peroxisome_proliferator_activated_receptor_gamma	4,52	amino acid	peroxisome proliferator activated receptor gamma	D000596	5468	Chemical	Gene	START_ENTITY|nsubj|expression expression|amod|END_ENTITY	The peroxisome_proliferator_activated_receptor_gamma agonist pioglitazone increases functional expression of the glutamate transporter excitatory amino_acid transporter 2 -LRB- EAAT2 -RRB- in human glioblastoma cells .
3379653	0	amino_acid	25,35	phenylethanolamine_N-methyltransferase	63,101	amino acid	phenylethanolamine N-methyltransferase	CHEBI:33704	281413(Tax:9913)	Chemical	Gene	sequence|compound|START_ENTITY sequence|nmod|END_ENTITY	Purification and partial amino_acid sequence of bovine adrenal phenylethanolamine_N-methyltransferase : a comparison of nucleic acid and protein sequence data .
6347186	0	amino_acid	13,23	phosphoglycerate_kinase	42,65	amino acid	phosphoglycerate kinase	CHEBI:33704	850370(Tax:4932)	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|nsubj|sequence	The complete amino_acid sequence of yeast phosphoglycerate_kinase .
6127696	0	amino_acid	4,14	phosphoglycerate_mutase	33,56	amino acid	phosphoglycerate mutase	CHEBI:33704	854457(Tax:4932)	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|nsubj|sequence	The amino_acid sequence of yeast phosphoglycerate_mutase .
10462455	0	amino_acid	30,40	phospholipase_A	79,94	amino acid	phospholipase A	CHEBI:33704	27281(Tax:10090)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Purification , properties , and amino_acid sequence of a hemoglobinuria-inducing phospholipase_A -LRB- 2 -RRB- , MiPLA-1 , from Micropechis ikaheka venom .
1122291	1	amino_acid	43,53	phospholipase_A	66,81	amino acid	phospholipase A	CHEBI:33704	57110	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The amino_acid sequence of phospholipase_A , fraction DE-III .
1122292	0	amino_acid	4,14	phospholipase_A	27,42	amino acid	phospholipase A	CHEBI:33704	57110	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The amino_acid sequence of phospholipase_A , fractions DE-I and DE-II .
11223097	0	amino_acid	18,28	phospholipase_A2	77,93	amino acid	phospholipase A2	CHEBI:33704	151056	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Characterization , amino_acid sequence and evolution of edema-inducing , basic phospholipase_A2 from Trimeresurus flavoviridis venom .
3240982	0	amino_acid	40,50	phospholipase_A2	69,85	amino acid	phospholipase A2	CHEBI:33704	151056	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Amino_acid composition and NH2-terminal amino_acid sequence of human phospholipase_A2 purified from rheumatoid synovial fluid .
7890667	0	amino_acid	30,40	phospholipase_C_delta_1	59,82	amino acid	phospholipase C delta 1	CHEBI:33704	5333	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Cloning and identification of amino_acid residues of human phospholipase_C_delta_1 essential for catalysis .
13886645	0	amino_acid	4,14	pituitary_growth_hormone	36,60	amino acid	pituitary growth hormone	CHEBI:33704	2688	Chemical	Gene	composition|amod|START_ENTITY composition|nmod|END_ENTITY	The amino_acid composition of human pituitary_growth_hormone .
3194393	0	amino_acid	9,19	placental_protein_14	38,58	amino acid	placental protein 14	CHEBI:33704	5047	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Complete amino_acid sequence of human placental_protein_14 : a progesterone-regulated uterine protein homologous to beta-lactoglobulins .
1897960	0	amino_acid	29,39	plasma_glutathione_peroxidase	58,87	amino acid	plasma glutathione peroxidase	CHEBI:33704	2878	Chemical	Gene	sequence|compound|START_ENTITY sequence|nmod|END_ENTITY	Characterization and partial amino_acid sequence of human plasma_glutathione_peroxidase .
4854644	0	amino_acid	4,14	plastocyanin	27,39	amino acid	plastocyanin	CHEBI:33704	102583807	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The amino_acid sequence of plastocyanin from Solanum_tuberosum_L .
3402609	0	amino_acid	9,19	platelet_proteoglycan	40,61	amino acid	platelet proteoglycan	CHEBI:33704	5552	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Complete amino_acid sequence of a human platelet_proteoglycan .
10863935	0	amino_acid	128,138	pleiotrophin	52,64	amino acid	pleiotrophin	CHEBI:33704	5764	Chemical	Gene	START_ENTITY|nsubj|synthesis synthesis|nmod|END_ENTITY	Solution synthesis and biological activity of human pleiotrophin , a novel heparin-binding neurotrophic factor consisting of 136 amino_acid residues with five disulfide bonds .
12652909	0	amino_acid	17,27	preproendothelin-2	48,66	amino acid	preproendothelin-2	CHEBI:33704	1907	Chemical	Gene	START_ENTITY|dobj|sequences sequences|nmod|END_ENTITY	cDNA and deduced amino_acid sequences of ferret preproendothelin-2 and phylogenetic analysis .
6129251	0	amino_acid	9,19	pro-opiomelanocortin	38,58	amino acid	pro-opiomelanocortin	CHEBI:33704	18976(Tax:10090)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Complete amino_acid sequence of mouse pro-opiomelanocortin derived from the nucleotide sequence of pro-opiomelanocortin cDNA .
329280	0	amino_acid	13,23	prochymosin	36,47	amino acid	prochymosin	CHEBI:33704	529879(Tax:9913)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The complete amino_acid sequence of prochymosin .
3551956	0	amino_acid	9,19	progesterone_receptor	42,63	amino acid	progesterone receptor	CHEBI:33704	5241	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Complete amino_acid sequence of the human progesterone_receptor deduced from cloned cDNA .
632300	0	amino_acid	4,14	proinsulin	95,105	amino acid	proinsulin	CHEBI:33704	3630	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The amino_acid sequence of human insulin-like_growth_factor_I and its structural homology with proinsulin .
11019904	0	amino_acid	63,73	prolactin	110,119	amino acid	prolactin	CHEBI:33704	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Interrelationships of GABAergic , serotoninergic and excitatory amino_acid systems in its regulatory effect on prolactin secretion in prepubertal rats .
17154384	0	amino_acid	152,162	prolactin	29,38	amino acid	prolactin	CHEBI:33704	707052(Tax:9544)	Chemical	Gene	role|nmod|START_ENTITY regulation|dep|role regulation|nmod|secretion secretion|compound|END_ENTITY	Neuroendocrine regulation of prolactin secretion in adult female rhesus_monkeys during different phases of the menstrual cycle : role of neuroexcitatory amino_acid -LRB- NMA -RRB- .
1791836	0	amino_acid	7,17	prolactin	54,63	amino acid	prolactin	CHEBI:33704	280901(Tax:9913)	Chemical	Gene	substitutions|amod|START_ENTITY substitutions|nmod|END_ENTITY	Single amino_acid substitutions in recombinant bovine prolactin that markedly reduce its mitogenic activity in Nb2 cell cultures .
1916208	0	amino_acid	13,23	prolactin	36,45	amino acid	prolactin	CHEBI:33704	5617	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The complete amino_acid sequence of prolactin from the bullfrog , Rana catesbeiana .
2289679	0	amino_acid	13,23	prolactin	36,45	amino acid	prolactin	CHEBI:33704	102944759	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The complete amino_acid sequence of prolactin from the sea turtle -LRB- Chelonia_mydas -RRB- .
3254687	0	amino_acid	23,33	prolactin	10,19	amino acid	prolactin	CHEBI:33704	24683(Tax:10116)	Chemical	Gene	catabolism|amod|START_ENTITY Effect|nmod|catabolism Effect|nmod|END_ENTITY	Effect of prolactin on amino_acid catabolism in the female rat .
3756168	1	amino_acid	166,176	prolactin	199,208	amino acid	prolactin	CHEBI:33704	19109(Tax:10090)	Chemical	Gene	compositions|amod|START_ENTITY compositions|nmod|END_ENTITY	The present study was undertaken to find out whether or not sexual dimorphism in biological activities and amino_acid compositions of mouse prolactin might be due to heterogeneity in mRNA for mouse prolactin Cloned cDNAs for mouse prolactin were first isolated from a mouse pituitary cDNA library by hybridization with a rat prolactin cDNA .
4026864	0	amino_acid	21,31	prolactin	54,63	amino acid	prolactin	CHEBI:33704	19109(Tax:10090)	Chemical	Gene	compositions|amod|START_ENTITY dimorphism|nmod|compositions dimorphism|nmod|END_ENTITY	Sexual dimorphism in amino_acid compositions of mouse prolactin .
6615535	0	amino_acid	50,60	prolactin	26,35	amino acid	prolactin	CHEBI:33704	5617	Chemical	Gene	START_ENTITY|nsubj|Radioimmunoassay Radioimmunoassay|nmod|END_ENTITY	Radioimmunoassay of human prolactin based on a 13 amino_acid synthetic analog of the amino terminus .
6697984	0	amino_acid	9,19	prolactin	38,47	amino acid	prolactin	CHEBI:33704	19109(Tax:10090)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Complete amino_acid sequence of mouse prolactin .
728396	0	amino_acid	9,19	prolactin	60,69	amino acid	prolactin	CHEBI:33704	24683(Tax:10116)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Complete amino_acid sequence of the precursor region of rat prolactin .
7383274	0	amino_acid	69,79	prolactin	15,24	amino acid	prolactin	CHEBI:33704	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Stimulation Stimulation|nmod|secretion secretion|compound|END_ENTITY	Stimulation of prolactin secretion by taurine , a neurally depressant amino_acid .
16864857	0	amino_acid	5,15	prolactin_receptor	65,83	amino acid	prolactin receptor	CHEBI:33704	414916(Tax:9823)	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	High amino_acid variation in the intracellular domain of the pig prolactin_receptor -LRB- PRLR -RRB- and its relation to ovulation rate and piglet survival traits .
2863307	0	amino_acid	28,38	proliferating_cell_nuclear_antigen	51,85	amino acid	proliferating cell nuclear antigen	CHEBI:33704	5111	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Purification and N-terminal amino_acid sequence of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- / cyclin and development of ELISA for anti-PCNA antibodies .
2956093	0	amino_acid	4,14	protein_II	27,37	amino acid	protein II	CHEBI:33704	307	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The amino_acid sequence of protein_II and its phosphorylation site for protein kinase C ; the domain structure Ca2 + - modulated lipid binding proteins .
3111460	0	amino_acid	12,22	proteoglycan	52,64	amino acid	proteoglycan	CHEBI:33704	395565(Tax:9031)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The partial amino_acid sequence of bovine cartilage proteoglycan , deduced from a cDNA clone , contains numerous Ser-Gly sequences arranged in homologous repeats .
10942794	0	amino_acid	32,42	prothrombin	68,79	amino acid	prothrombin	CHEBI:33704	2147	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Determination of the N-terminal amino_acid sequence of the purified prothrombin from a patient with liver_cirrhosis .
18590276	0	amino_acid	46,56	prothrombinase	117,131	amino acid	prothrombinase	CHEBI:33704	2159	Chemical	Gene	START_ENTITY|nmod|function function|nmod|END_ENTITY	Role of the acidic hirudin-like COOH-terminal amino_acid region of factor Va heavy chain in the enhanced function of prothrombinase .
3532956	0	amino_acid	25,35	prothymosin_alpha	6,23	amino acid	prothymosin alpha	CHEBI:33704	100506248	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|dep|sequence	Human prothymosin_alpha : amino_acid sequence and immunologic properties .
2878111	0	amino_acid	6,16	pyruvate_carboxylase	34,54	amino acid	pyruvate carboxylase	CHEBI:33704	5091	Chemical	Gene	START_ENTITY|nmod|deficiency deficiency|amod|END_ENTITY	Brain amino_acid abnormalities in pyruvate_carboxylase deficiency .
7918683	0	amino_acid	8,18	pyruvate_carboxylase	51,71	amino acid	pyruvate carboxylase	CHEBI:33704	5091	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Primary amino_acid sequence and structure of human pyruvate_carboxylase .
10506149	0	amino_acid	40,50	rBAT	114,118	amino acid	rBAT	CHEBI:33704	29725(Tax:10116)	Chemical	Gene	transporter|amod|START_ENTITY transporter|acl|functioning functioning|nmod|heterodimer heterodimer|nmod|4F2hc 4F2hc|nmod|END_ENTITY	Cloning and expression of a b -LRB- 0 , + -RRB- - like amino_acid transporter functioning as a heterodimer with 4F2hc instead of rBAT .
14561219	0	amino_acid	83,93	rBAT	20,24	amino acid	rBAT	CHEBI:33704	29725(Tax:10116)	Chemical	Gene	rBAT-b0|amod|START_ENTITY pathways|nmod|rBAT-b0 mutation|dep|pathways mutation|compound|END_ENTITY	Cystinuria-specific rBAT -LRB- R365W -RRB- mutation reveals two translocation pathways in the amino_acid transporter rBAT-b0 , + AT .
16825196	1	amino_acid	143,153	rBAT	94,98	amino acid	rBAT	CHEBI:33704	29725(Tax:10116)	Chemical	Gene	transporters|amod|START_ENTITY oligomerization|nmod|transporters dictates|dobj|oligomerization dictates|nsubj|END_ENTITY	The heavy subunit rBAT dictates oligomerization of the heteromeric amino_acid transporters .
19878315	0	amino_acid	68,78	rBAT	92,96	amino acid	rBAT	CHEBI:33704	29725(Tax:10116)	Chemical	Gene	subunits|nmod|START_ENTITY ancestry|nmod|subunits Looking|nmod|ancestry transporters|csubj|Looking transporters|dobj|END_ENTITY	Looking for the ancestry of the heavy-chain subunits of heteromeric amino_acid transporters rBAT and 4F2hc within the GH13 alpha-amylase family .
7805832	0	amino_acid	13,23	rBAT	41,45	amino acid	rBAT	CHEBI:33704	29725(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|exchange exchange|nmod|transporter transporter|amod|END_ENTITY	Electrogenic amino_acid exchange via the rBAT transporter .
7823016	0	amino_acid	80,90	rBAT	26,30	amino acid	rBAT	CHEBI:33704	29725(Tax:10116)	Chemical	Gene	transport|amod|START_ENTITY involved|nmod|transport proteins|acl|involved proteins|dep|END_ENTITY	A new family of proteins -LRB- rBAT and 4F2hc -RRB- involved in cationic and zwitterionic amino_acid transport : a tale of two proteins in search of a transport function .
8631857	0	amino_acid	70,80	rBAT	4,8	amino acid	rBAT	CHEBI:33704	29725(Tax:10116)	Chemical	Gene	system|amod|START_ENTITY uptake|dep|system responsible|nmod|uptake responsible|nsubj|gene gene|compound|END_ENTITY	The rBAT gene is responsible for L-cystine uptake via the b0 , -LRB- + -RRB- - like amino_acid transport system in a `` renal proximal tubular '' cell line -LRB- OK cells -RRB- .
8825523	0	amino_acid	11,21	rBAT	0,4	amino acid	rBAT	CHEBI:33704	29725(Tax:10116)	Chemical	Gene	exchanger|amod|START_ENTITY exchanger|nsubj|END_ENTITY	rBAT is an amino_acid exchanger with variable stoichiometry .
8963675	0	amino_acid	10,20	rBAT	34,38	amino acid	rBAT	CHEBI:33704	29725(Tax:10116)	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	The basic amino_acid transporter -LRB- rBAT -RRB- - like immunoreactivity in paraventricular and supraoptic magnocellular neurons of the rat hypothalamus .
10568789	0	amino_acid	5,15	rbslo1	58,64	amino acid	rbslo1	CHEBI:33704	100008745(Tax:9986)	Chemical	Gene	sensitivity|amod|START_ENTITY sensitivity|nmod|END_ENTITY	A 59 amino_acid insertion increases Ca -LRB- 2 + -RRB- sensitivity of rbslo1 , a Ca2 + - activated K -LRB- + -RRB- channel in renal_epithelia .
1672047	5	amino_acid	644,654	recoverin	667,676	amino acid	recoverin	CHEBI:33704	5957	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The amino_acid sequence of recoverin exhibits three potential calcium binding sites -LRB- EF hands -RRB- .
7913468	0	amino_acid	23,33	retinoic_acid_receptor	45,67	amino acid	retinoic acid receptor	CHEBI:33704	5914	Chemical	Gene	residue|amod|START_ENTITY residue|nmod|END_ENTITY	Alteration of a single amino_acid residue in retinoic_acid_receptor causes dominant-negative phenotype .
573775	0	amino_acid	8,18	retinol-binding_protein	44,67	amino acid	retinol-binding protein	CHEBI:33704	5950	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Partial amino_acid sequence of human plasma retinol-binding_protein .
7608189	1	amino_acid	134,144	rhodanese	225,234	amino acid	rhodanese	CHEBI:33704	25274(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	Striking similarity in active site amino_acid sequence and the increase in the mercaptopyruvate_sulfurtransferase activity of rhodanese by site-directed mutagenesis .
10736699	0	amino_acid	34,44	rhodopsin	61,70	amino acid	rhodopsin	D000596	6010	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Mapping tertiary contacts between amino_acid residues within rhodopsin .
8223579	0	amino_acid	4,14	ribonuclease_4	33,47	amino acid	ribonuclease 4	CHEBI:33704	6041	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The amino_acid sequence of human ribonuclease_4 , a highly conserved ribonuclease that cleaves specifically on the 3 ' side of uridine .
10788798	0	amino_acid	57,67	ribonuclease_A	133,147	amino acid	ribonuclease A	CHEBI:33704	282340(Tax:9913)	Chemical	Gene	START_ENTITY|nmod|properties properties|nmod|END_ENTITY	Effect of mutagenic replacement of the carboxyl terminal amino_acid , val124 , on the properties and regeneration of bovine pancreatic ribonuclease_A .
16233267	0	amino_acid	79,89	ribonuclease_A	52,66	amino acid	ribonuclease A	CHEBI:33704	282340(Tax:9913)	Chemical	Gene	residues|amod|START_ENTITY END_ENTITY|nmod|residues	Replacement of His12 or His119 of bovine pancreatic ribonuclease_A with acidic amino_acid residues for the modification of activity and stability .
8218404	0	amino_acid	23,33	ribosomal_protein_L18	52,73	amino acid	ribosomal protein L18	CHEBI:33704	6141	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Nucleotide and deduced amino_acid sequence of human ribosomal_protein_L18 .
6434350	0	amino_acid	9,19	seminal_plasma_beta-inhibin	38,65	amino acid	seminal plasma beta-inhibin	CHEBI:33704	4477	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Complete amino_acid sequence of human seminal_plasma_beta-inhibin .
1398711	0	amino_acid	8,18	serine_hydroxymethyltransferase	43,74	amino acid	serine hydroxymethyltransferase	CHEBI:33704	443544(Tax:9940)	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Partial amino_acid sequence of sheep liver serine_hydroxymethyltransferase and comparison of peptide maps of the enzyme from human , ox livers and Escherichia_coli .
8863842	0	amino_acid	27,37	serotonin_transporter	153,174	amino acid	serotonin transporter	CHEBI:33704	6532	Chemical	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of a single amino_acid , phenylalanine 586 , that is responsible for high affinity interactions of tricyclic antidepressants with the human serotonin_transporter .
8316768	0	amino_acid	12,22	serum_amyloid_A	35,50	amino acid	serum amyloid A	CHEBI:33704	6287	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|protein protein|amod|END_ENTITY	The revised amino_acid sequence of serum_amyloid_A -LRB- SAA -RRB- protein in mink .
2432609	0	amino_acid	66,76	sex_hormone-binding_globulin	106,134	amino acid	sex hormone-binding globulin	CHEBI:33704	6462	Chemical	Gene	homology|amod|START_ENTITY homology|nmod|END_ENTITY	Rat androgen-binding_protein : evidence for identical subunits and amino_acid sequence homology with human sex_hormone-binding_globulin .
1510947	0	amino_acid	48,58	sex_hormone_binding_globulin	98,126	amino acid	sex hormone binding globulin	CHEBI:33704	6462	Chemical	Gene	START_ENTITY|nmod|site site|nmod|END_ENTITY	Characterization of Met-139 as the photolabeled amino_acid residue in the steroid binding site of sex_hormone_binding_globulin using delta 6 derivatives of either testosterone or estradiol as unsubstituted photoaffinity labeling reagents .
7106126	0	amino_acid	11,21	sialoglycoprotein_D	34,53	amino acid	sialoglycoprotein D	CHEBI:33704	2995	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	N-terminal amino_acid sequence of sialoglycoprotein_D -LRB- glycophorin_C -RRB- from human erythrocyte membranes .
16373326	0	amino_acid	30,40	slc36a1	59,66	amino acid	slc36a1	CHEBI:33704	100008971(Tax:9986)	Chemical	Gene	PAT1|amod|START_ENTITY PAT1|appos|END_ENTITY	Isolation and function of the amino_acid transporter PAT1 -LRB- slc36a1 -RRB- from rabbit and discrimination between transport via PAT1 and system IMINO in renal brush-border membrane vesicles .
2568964	0	amino_acid	33,43	somatostatin	10,22	amino acid	somatostatin	CHEBI:33704	6750	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of somatostatin on plasma amino_acid uptake by human pancreas .
3280805	0	amino_acid	23,33	stp	46,49	amino acid	stp	CHEBI:33704	1258673(Tax:10665)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Nucleotide and deduced amino_acid sequence of stp : the bacteriophage_T4 anticodon nuclease gene .
429329	0	amino_acid	4,14	substance_P	47,58	amino acid	substance P	CHEBI:33704	281512(Tax:9913)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The amino_acid sequence of bovine hypothalamic substance_P .
7518066	0	amino_acid	47,57	substance_P	20,31	amino acid	substance P	CHEBI:33704	6863	Chemical	Gene	START_ENTITY|nsubj|Interaction Interaction|nmod|END_ENTITY	Interaction between substance_P and excitatory amino_acid receptors in modulation of nociceptive responses of cat spinal dorsal horn neurons .
17897946	0	amino_acid	57,67	tax	53,56	amino acid	tax	CHEBI:33704	1491938(Tax:11908)	Chemical	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification of human T_cell_leukemia_virus_type_1 tax amino_acid signals and cellular factors involved in secretion of the viral oncoprotein .
1112834	0	amino_acid	4,14	testis-specific_basic_protein	29,58	amino acid	testis-specific basic protein	CHEBI:33704	414826(Tax:10116)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The amino_acid sequence of a testis-specific_basic_protein that is associated with spermatogenesis .
2189409	0	amino_acid	9,19	thioltransferase	38,54	amino acid	thioltransferase	CHEBI:33704	397463(Tax:9823)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Complete amino_acid sequence of yeast thioltransferase -LRB- glutaredoxin -RRB- .
2033077	0	amino_acid	23,33	threonyl-tRNA_synthetase	52,76	amino acid	threonyl-tRNA synthetase	CHEBI:33704	6897	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Nucleotide and deduced amino_acid sequence of human threonyl-tRNA_synthetase reveals extensive homology to the Escherichia_coli and yeast enzymes .
11307817	0	amino_acid	4,14	thrombin	64,72	amino acid	thrombin	CHEBI:33704	2147	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|nsubj|sequence	The amino_acid sequence in fibrin responsible for high affinity thrombin binding .
8288594	0	amino_acid	24,34	thrombin	47,55	amino acid	thrombin	CHEBI:33704	2147	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Identification of basic amino_acid residues in thrombin essential for heparin-catalyzed inactivation by antithrombin III .
3712376	0	amino_acid	74,84	thymidylate_synthase	35,55	amino acid	thymidylate synthase	CHEBI:33704	22171(Tax:10090)	Chemical	Gene	variation|nmod|START_ENTITY END_ENTITY|dep|variation	Quinazoline antifolates inhibiting thymidylate_synthase : variation of the amino_acid .
3839505	0	amino_acid	30,40	thymidylate_synthase	59,79	amino acid	thymidylate synthase	CHEBI:33704	22171(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Purification and NH2-terminal amino_acid sequence of human thymidylate_synthase in an overproducing transformant of mouse FM3A cells .
1171728	0	amino_acid	4,14	thymopoietin_II	27,42	amino acid	thymopoietin II	CHEBI:33704	510267(Tax:9913)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The amino_acid sequence of thymopoietin_II .
6940133	0	amino_acid	9,19	thymosin_beta_4	39,54	amino acid	thymosin beta 4	CHEBI:33704	100137883(Tax:9913)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Complete amino_acid sequence of bovine thymosin_beta_4 : a thymic hormone that induces terminal_deoxynucleotidyl_transferase activity in thymocyte populations .
2345166	0	amino_acid	43,53	thyroglobulin	73,86	amino acid	thyroglobulin	CHEBI:33704	280706(Tax:9913)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Location of dehydroalanine residues in the amino_acid sequence of bovine thyroglobulin .
3094014	0	amino_acid	9,19	thyroxine-binding_globulin	38,64	amino acid	thyroxine-binding globulin	CHEBI:33704	6906	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Complete amino_acid sequence of human thyroxine-binding_globulin deduced from cloned DNA : close homology to the serine antiproteases .
8223615	6	amino_acid	785,795	tms1	808,812	amino acid	tms1	CHEBI:33704	851682(Tax:4932)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Comparison of the deduced amino_acid sequence of tms1 with available databases revealed significant similarity to dehydrogenases , suggesting that the tms1 protein itself might possess dehydrogenase activity .
1708393	0	amino_acid	34,44	transcobalamin_II	63,80	amino acid	transcobalamin II	CHEBI:33704	6948	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The cDNA sequence and the deduced amino_acid sequence of human transcobalamin_II show homology with rat intrinsic factor and human transcobalamin_I .
6953407	0	amino_acid	13,23	transferrin	48,59	amino acid	transferrin	CHEBI:33704	7018	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The complete amino_acid sequence of human serum transferrin .
8019440	0	amino_acid	4,14	transition_protein_1	60,80	amino acid	transition protein 1	CHEBI:33704	7141	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The amino_acid sequence and phosphorylation sites of a boar transition_protein_1 .
2298812	0	amino_acid	17,27	trichohyalin	41,53	amino acid	trichohyalin	CHEBI:33704	101120969	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The cDNA-deduced amino_acid sequence for trichohyalin , a differentiation marker in the hair follicle , contains a 23 amino_acid repeat .
1656173	1	amino_acid	150,160	tropoelastin	177,189	amino acid	tropoelastin	CHEBI:33704	2006	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	We have recently derived the complete amino_acid sequence of rat tropoelastin from a series of overlapping cDNA clones .
1670638	0	amino_acid	158,168	tumor_necrosis_factor	29,50	amino acid	tumor necrosis factor	CHEBI:33704	7124	Chemical	Gene	variant|acl|START_ENTITY correlates|nmod|variant locus|parataxis|correlates locus|nsubj|structure structure|nmod|END_ENTITY	Polymorphic structure of the tumor_necrosis_factor -LRB- TNF -RRB- locus : an NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino_acid in position 26 and a reduced level of TNF-beta production .
4030139	0	amino_acid	25,35	tumor_necrosis_factor	55,76	amino acid	tumor necrosis factor	CHEBI:33704	100009088(Tax:9986)	Chemical	Gene	sequence|compound|START_ENTITY sequence|nmod|END_ENTITY	Purification and partial amino_acid sequence of rabbit tumor_necrosis_factor .
8048001	0	amino_acid	66,76	tumor_necrosis_factor	12,33	amino acid	tumor necrosis factor	CHEBI:33704	103694380	Chemical	Gene	transport|amod|START_ENTITY attenuates|dobj|transport attenuates|nsubj|Antibody Antibody|nmod|END_ENTITY	Antibody to tumor_necrosis_factor attenuates endotoxin-stimulated amino_acid transport in rat liver .
8322145	0	amino_acid	59,69	tumor_necrosis_factor	10,31	amino acid	tumor necrosis factor	CHEBI:33704	103694380	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of tumor_necrosis_factor or interleukin-1 on muscle amino_acid uptake and the role of glucocorticoids .
16117322	0	amino_acid	61,71	tumor_necrosis_factor-alpha	11,38	amino acid	tumor necrosis factor-alpha	CHEBI:33704	24835(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of tumor_necrosis_factor-alpha on insulin stimulated amino_acid transport in cultured rat hepatocytes .
8778147	0	amino_acid	58,68	tumor_necrosis_factor_alpha	11,38	amino acid	tumor necrosis factor alpha	CHEBI:33704	24835(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of tumor_necrosis_factor_alpha on skeletal muscle amino_acid metabolism studied in-vivo .
2874553	0	amino_acid	110,120	tyrosine_hydroxylase	139,159	amino acid	tyrosine hydroxylase	CHEBI:33704	25085(Tax:10116)	Chemical	Gene	homology|amod|START_ENTITY homology|nmod|END_ENTITY	Complete nucleotide and deduced amino_acid sequence of bovine phenylethanolamine_N-methyltransferase : partial amino_acid homology with rat tyrosine_hydroxylase .
2899135	0	amino_acid	10,20	tyrosine_hydroxylase	40,60	amino acid	tyrosine hydroxylase	CHEBI:33704	280707(Tax:9913)	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Predicted amino_acid sequence of bovine tyrosine_hydroxylase and its similarity to tyrosine_hydroxylases from other species .
1170880	0	amino_acid	13,23	ubiquitin	36,45	amino acid	ubiquitin	CHEBI:33704	101902760	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The complete amino_acid sequence of ubiquitin , an adenylate cyclase stimulating polypeptide probably universal in living cells .
2713345	0	amino_acid	51,61	uracil-DNA_glycosylase	74,96	amino acid	uracil-DNA glycosylase	CHEBI:33704	7374	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Purification and determination of the NH2-terminal amino_acid sequence of uracil-DNA_glycosylase from human placenta .
3267221	0	amino_acid	42,52	uricase	75,82	amino acid	uricase	CHEBI:33704	547453(Tax:3847)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Nucleotide sequence of cDNA and predicted amino_acid sequence of rat liver uricase .
3243851	0	amino_acid	25,35	urine_protein_1	54,69	amino acid	urine protein 1	CHEBI:33704	7356	Chemical	Gene	sequence|compound|START_ENTITY sequence|nmod|END_ENTITY	Purification and partial amino_acid sequence of human urine_protein_1 .
12021053	0	amino_acid	46,56	uteroglobin	75,86	amino acid	uteroglobin	CHEBI:33704	100630519	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Full-length complementary DNA and the derived amino_acid sequence of horse uteroglobin .
7594538	0	amino_acid	25,35	vascular_cell_adhesion_molecule-1	48,81	amino acid	vascular cell adhesion molecule-1	CHEBI:33704	22329(Tax:10090)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Similar but nonidentical amino_acid residues on vascular_cell_adhesion_molecule-1 are involved in the interaction with alpha_4_beta 1 and alpha_4_beta 7 under different activity states .
7440061	2	amino_acid	96,106	vasoactive_intestinal_polypeptide	127,160	amino acid	vasoactive intestinal polypeptide	CHEBI:33704	396323(Tax:9031)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Synthesis of an octacosapeptide amide corresponding to the entire amino_acid sequence of chicken vasoactive_intestinal_polypeptide -LRB- VIP -RRB- .
14526263	0	amino_acid	20,30	vasopressin	40,51	amino acid	vasopressin	CHEBI:33704	551	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Influence of plasma amino_acid level on vasopressin secretion .
8736923	0	amino_acid	8,18	vitamin_B12_dependent_methionine_synthase	48,89	amino acid	vitamin B12 dependent methionine synthase	CHEBI:33704	4548	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Sulphur amino_acid derivatives as inhibitors of vitamin_B12_dependent_methionine_synthase .
2423133	0	amino_acid	9,19	vitamin_D-binding_protein	38,63	amino acid	vitamin D-binding protein	CHEBI:33704	2638	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Complete amino_acid sequence of human vitamin_D-binding_protein -LRB- group-specific component -RRB- : evidence of a three-fold internal homology as in serum albumin and alpha-fetoprotein .
23492558	4	amino_acid	873,883	vitellogenin	896,908	amino acid	vitellogenin	CHEBI:33704	424533(Tax:9031)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The fractions of MW about 4 and 12 kDa are free of carbohydrates and start at position 1732 in the vitellogenin amino_acid sequence ; whereas the other fractions -LRB- MW about 16 , 19 , 23 , 29 , 32 and 35 kDa -RRB- appeared to be glycoproteins corresponding to the amino_acid sequence of vitellogenin starting at position 1572 .
2414098	0	amino_acid	9,19	vitronectin	38,49	amino acid	vitronectin	CHEBI:33704	7448	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Complete amino_acid sequence of human vitronectin deduced from cDNA .
16529809	0	amino_acid_esters	53,70	Angiotensin_converting_enzyme	0,29	amino acid esters	Angiotensin converting enzyme	CHEBI:46668	1636	Chemical	Gene	activity|nmod|START_ENTITY END_ENTITY|dobj|activity	Angiotensin_converting_enzyme inhibitory activity of amino_acid_esters of carbohydrates .
17419840	0	amino_acids	26,37	AAP1	0,4	amino acids	AAP1	CHEBI:33709	842205(Tax:3702)	Chemical	Gene	transports|dobj|START_ENTITY transports|nsubj|END_ENTITY	AAP1 transports uncharged amino_acids into roots of Arabidopsis .
16388118	0	amino_acids	40,51	ACTH	11,15	amino acids	ACTH	CHEBI:33709	5443	Chemical	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Control of ACTH secretion by excitatory amino_acids : functional significance and clinical implications .
6093817	0	amino_acids	218,229	ACTH	116,120	amino acids	ACTH	CHEBI:33709	5443	Chemical	Gene	-RSB-|nmod:npmod|START_ENTITY hexa-amino_acids|amod|-RSB- containing|dobj|hexa-amino_acids tetracosapeptides|acl|containing Structural|dep|tetracosapeptides Structural|dep|11-24 11-24|dep|tetradeca tetradeca|dep|END_ENTITY	-LSB- Structural and functional organization of ACTH : synthesis and properties of analogs of ACTH - -LRB- 11-24 -RRB- - tetradeca - and ACTH - -LRB- 1-24 -RRB- - tetracosapeptides containing hexa-amino_acids instead of a natural sequence of ACTH 19-24 amino_acids -RSB- .
6093817	0	amino_acids	218,229	ACTH	207,211	amino acids	ACTH	CHEBI:33709	5443	Chemical	Gene	-RSB-|nmod:npmod|START_ENTITY hexa-amino_acids|amod|-RSB- hexa-amino_acids|nmod|sequence sequence|nmod|END_ENTITY	-LSB- Structural and functional organization of ACTH : synthesis and properties of analogs of ACTH - -LRB- 11-24 -RRB- - tetradeca - and ACTH - -LRB- 1-24 -RRB- - tetracosapeptides containing hexa-amino_acids instead of a natural sequence of ACTH 19-24 amino_acids -RSB- .
6093817	0	amino_acids	218,229	ACTH	43,47	amino acids	ACTH	CHEBI:33709	5443	Chemical	Gene	-RSB-|nmod:npmod|START_ENTITY hexa-amino_acids|amod|-RSB- containing|dobj|hexa-amino_acids tetracosapeptides|acl|containing Structural|dep|tetracosapeptides Structural|nmod|END_ENTITY	-LSB- Structural and functional organization of ACTH : synthesis and properties of analogs of ACTH - -LRB- 11-24 -RRB- - tetradeca - and ACTH - -LRB- 1-24 -RRB- - tetracosapeptides containing hexa-amino_acids instead of a natural sequence of ACTH 19-24 amino_acids -RSB- .
6093817	0	amino_acids	218,229	ACTH	88,92	amino acids	ACTH	CHEBI:33709	5443	Chemical	Gene	-RSB-|nmod:npmod|START_ENTITY hexa-amino_acids|amod|-RSB- containing|dobj|hexa-amino_acids tetracosapeptides|acl|containing Structural|dep|tetracosapeptides Structural|dep|synthesis synthesis|nmod|analogs analogs|nmod|END_ENTITY	-LSB- Structural and functional organization of ACTH : synthesis and properties of analogs of ACTH - -LRB- 11-24 -RRB- - tetradeca - and ACTH - -LRB- 1-24 -RRB- - tetracosapeptides containing hexa-amino_acids instead of a natural sequence of ACTH 19-24 amino_acids -RSB- .
8830675	0	amino_acids	31,42	AT1	50,53	amino acids	AT1	CHEBI:33709	24180(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	Identification of nonconserved amino_acids in the AT1 receptor which comprise a general binding site for biphenylimidazole antagonists .
16775502	0	amino_acids	27,38	Akt	63,66	amino acids	Akt	CHEBI:33709	207	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|END_ENTITY	In human endothelial cells amino_acids inhibit insulin-induced Akt and ERK1/2 phosphorylation by an mTOR-dependent mechanism .
11522791	6	amino_acids	765,776	Ap-2delta	733,742	amino acids	Ap-2delta	CHEBI:33709	226896(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|protein protein|compound|END_ENTITY	The predicted Ap-2delta protein comprised 452 amino_acids and was highly similar to other AP-2 proteins across the DNA-binding and dimerization domains .
8065006	0	amino_acids	12,23	ApoB100	27,34	amino acids	ApoB100	CHEBI:33709	338	Chemical	Gene	START_ENTITY|nmod|synthesis synthesis|amod|END_ENTITY	The role of amino_acids in ApoB100 synthesis and catabolism in human HepG2 cells .
8262926	0	amino_acids	12,23	ApoB100	27,34	amino acids	ApoB100	CHEBI:33709	338	Chemical	Gene	START_ENTITY|nmod|synthesis synthesis|amod|END_ENTITY	The role of amino_acids in ApoB100 synthesis and catabolism in human HepG2 cells .
6149788	0	amino_acids	95,106	Arginine-vasopressin	0,20	amino acids	Arginine-vasopressin	CHEBI:33709	24221(Tax:10116)	Chemical	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	Arginine-vasopressin enhances the responses of lateral septal neurons in the rat to excitatory amino_acids and fimbria-fornix stimuli .
24709150	0	amino_acids	130,141	AtCAT2	100,106	amino acids	AtCAT2	CHEBI:33709	842170(Tax:3702)	Chemical	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Characterization of the putative amino_acid transporter genes AtCAT2 , 3 _ 4 : the tonoplast localized AtCAT2 regulates soluble leaf amino_acids .
24709150	0	amino_acids	130,141	AtCAT2	62,68	amino acids	AtCAT2	CHEBI:33709	842170(Tax:3702)	Chemical	Gene	regulates|dobj|START_ENTITY amino_acid|parataxis|regulates amino_acid|dobj|END_ENTITY	Characterization of the putative amino_acid transporter genes AtCAT2 , 3 _ 4 : the tonoplast localized AtCAT2 regulates soluble leaf amino_acids .
20118605	0	amino_acids	51,62	Avt6	13,17	amino acids	Avt6	CHEBI:33709	856855(Tax:4932)	Chemical	Gene	Evidence|nmod|START_ENTITY Evidence|nmod|END_ENTITY	Evidence for Avt6 as a vacuolar exporter of acidic amino_acids in Saccharomyces_cerevisiae cells .
1254246	0	amino_acids	75,86	B24-26	87,93	amino acids	B24-26	CHEBI:33709	946898(Tax:511145)	Chemical	Gene	due|nmod|START_ENTITY END_ENTITY|amod|due	Further studies on the three-step-increase in activity due to the aromatic amino_acids B24-26 -LRB- - Phe-Phe-Tyr - -RRB- .
1358646	0	amino_acids	39,50	CA1	83,86	amino acids	CA1	CHEBI:33709	759	Chemical	Gene	release|nmod|START_ENTITY inhibits|dobj|release inhibits|nmod|slices slices|nmod|END_ENTITY	Ethanol inhibits release of excitatory amino_acids from slices of hippocampal area CA1 .
2452481	0	amino_acids	60,71	CA1	75,78	amino acids	CA1	CHEBI:33709	759	Chemical	Gene	START_ENTITY|nmod|neurons neurons|nummod|END_ENTITY	Sustained dendritic gradients of Ca2 + induced by excitatory amino_acids in CA1 hippocampal neurons .
6664465	0	amino_acids	44,55	CA1	71,74	amino acids	CA1	CHEBI:33709	759	Chemical	Gene	START_ENTITY|nmod|neurons neurons|compound|END_ENTITY	Relative potency of analogues of excitatory amino_acids on hippocampal CA1 neurons .
10570291	0	amino_acids	39,50	CD14	76,80	amino acids	CD14	CHEBI:33709	929	Chemical	Gene	impact|nmod|START_ENTITY impact|nmod|END_ENTITY	Differential impact of substitution of amino_acids 9-13 and 91-101 of human CD14 on soluble CD14-dependent activation of cells by lipopolysaccharide .
7534291	0	amino_acids	70,81	CD14	57,61	amino acids	CD14	CHEBI:33709	929	Chemical	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of a lipopolysaccharide binding domain in CD14 between amino_acids 57 and 64 .
23478129	0	amino_acids	30,41	CFTR	0,4	amino acids	CFTR	CHEBI:33709	1080	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|dep|effect	CFTR : effect of ICL2 and ICL4 amino_acids in close spatial proximity on the current properties of the channel .
25024266	0	amino_acids	14,25	CFTR	109,113	amino acids	CFTR	CHEBI:33709	1080	Chemical	Gene	involved|nsubjpass|START_ENTITY involved|advcl|maintaining maintaining|dobj|architecture architecture|nmod|END_ENTITY	Three charged amino_acids in extracellular loop 1 are involved in maintaining the outer pore architecture of CFTR .
7526852	0	amino_acids	50,61	CFTR	0,4	amino acids	CFTR	CHEBI:33709	12638(Tax:10090)	Chemical	Gene	efflux|nmod|START_ENTITY involved|nmod|efflux involved|nsubjpass|protein protein|amod|END_ENTITY	CFTR protein is involved in the efflux of neutral amino_acids .
25005938	0	amino_acids	10,21	CIN85	51,56	amino acids	CIN85	CHEBI:33709	30011	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	The basic amino_acids in the coiled-coil domain of CIN85 regulate its interaction with c-Cbl and phosphatidic_acid during epidermal_growth_factor_receptor -LRB- EGFR -RRB- endocytosis .
21861484	0	amino_acids	27,38	CO2	42,45	amino acids	CO2	CHEBI:33709	717	Chemical	Gene	efficacy|nmod|START_ENTITY Evaluating|dobj|efficacy Evaluating|advcl|END_ENTITY	Evaluating the efficacy of amino_acids as CO2 capturing agents : a first principles investigation .
24635834	0	amino_acids	43,54	CO2	20,23	amino acids	CO2	CHEBI:33709	717	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of elevated CO2 on the extractable amino_acids of leaf litter and fine roots .
8524872	0	amino_acids	44,55	CO2	75,78	amino acids	CO2	CHEBI:33709	717	Chemical	Gene	synthesis|nmod|START_ENTITY Investigation|nmod|synthesis bases|nsubj|Investigation bases|advcl|using using|nsubj|END_ENTITY	Investigation of the prebiotic synthesis of amino_acids and RNA bases from CO2 using FeS/H2S as a reducing agent .
20840750	0	amino_acids	22,33	CRY2	68,72	amino acids	CRY2	CHEBI:33709	12953(Tax:10090)	Chemical	Gene	Identification|nmod|START_ENTITY END_ENTITY|nsubj|Identification	Identification of two amino_acids in the C-terminal domain of mouse CRY2 essential for PER2 interaction .
9347948	0	amino_acids	66,77	Cholecystokinin	0,15	amino acids	Cholecystokinin	CHEBI:33709	25298(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY modulates|dobj|release modulates|nsubj|END_ENTITY	Cholecystokinin -LRB- CCK-8 -RRB- modulates vesicular release of excitatory amino_acids in rat hippocampal nerve endings .
10835346	5	amino_acids	594,605	DPM1	622,626	amino acids	DPM3	CHEBI:33709	54344	Chemical	Gene	START_ENTITY|acl|associated associated|nmod|END_ENTITY	The third subunit , DPM3 , comprises 92 amino_acids associated with DPM1 via its C-terminal domain and with DPM2 via its N-terminal portion .
1987790	0	amino_acids	38,49	GH	70,72	amino acids	GH	CHEBI:33709	443329(Tax:9940)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|nmod|END_ENTITY	Effects of intravenous infusion of 17 amino_acids on the secretion of GH , glucagon , and insulin in sheep .
9111034	0	amino_acids	18,29	GluR3	57,62	amino acids	GluR3	CHEBI:33709	2892	Chemical	Gene	START_ENTITY|nmod|receptor receptor|appos|END_ENTITY	Identification of amino_acids in the glutamate receptor , GluR3 , important for antibody-binding and receptor-specific activation .
24412429	0	amino_acids	67,78	Glucose-dependent_insulinotropic_polypeptide	0,44	amino acids	Glucose-dependent insulinotropic polypeptide	CHEBI:33709	25040(Tax:10116)	Chemical	Gene	lowers|dobj|START_ENTITY lowers|nsubj|END_ENTITY	Glucose-dependent_insulinotropic_polypeptide lowers branched chain amino_acids in hyperglycemic rats .
23873822	0	amino_acids	59,70	HLA-B	74,79	amino acids	HLA-B	CHEBI:33709	3106	Chemical	Gene	START_ENTITY|nmod|protein protein|amod|END_ENTITY	Association of Takayasu_arteritis with HLA-B 67:01 and two amino_acids in HLA-B protein .
18076037	0	amino_acids	101,112	HPBP	125,129	amino acids	HPBP	CHEBI:33709	100144632	Chemical	Gene	sequence|compound|START_ENTITY sequence|nmod|END_ENTITY	Tandem use of X-ray crystallography and mass spectrometry to obtain ab initio the complete and exact amino_acids sequence of HPBP , a human 38-kDa apolipoprotein .
22444872	0	amino_acids	113,124	Hsp90	137,142	amino acids	Hsp90	CHEBI:33709	104434(Tax:10090)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Sulforaphane inhibits pancreatic_cancer through disrupting Hsp90-p50 -LRB- Cdc37 -RRB- complex and direct interactions with amino_acids residues of Hsp90 .
26621633	0	amino_acids	17,28	IGF-I	39,44	amino acids	IGF-I	MESH:D000596	3479	Chemical	Gene	Role|nmod|START_ENTITY END_ENTITY|nsubj|Role	Role of selected amino_acids on plasma IGF-I concentration in infants .
11600567	0	amino_acids	27,38	IGF-binding_protein-3	67,88	amino acids	IGF-binding protein-3	CHEBI:33709	3486	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Mutation of three critical amino_acids of the N-terminal domain of IGF-binding_protein-3 essential for high affinity IGF binding .
10469544	0	amino_acids	40,51	Insulin	63,70	amino acids	Insulin	CHEBI:33709	3630	Chemical	Gene	Poly|appos|START_ENTITY Colloids|nmod|Poly Colloids|dep|That That|dep|END_ENTITY	Macromolecular Colloids of Diblock Poly -LRB- amino_acids -RRB- That Bind Insulin .
15845920	0	amino_acids	169,180	Insulin	0,7	amino acids	Insulin	CHEBI:33709	3630	Chemical	Gene	availability|nmod|START_ENTITY myotubes|nmod|availability complex|nmod|myotubes formation|nmod|complex stimulate|dobj|formation stimulate|nsubj|END_ENTITY	Insulin and IGF-I stimulate the formation of the eukaryotic initiation factor 4F complex and protein synthesis in C2C12 myotubes independent of availability of external amino_acids .
21636960	0	amino_acids	40,51	Insulin	0,7	amino acids	Insulin	CHEBI:33709	493804(Tax:9685)	Chemical	Gene	administrations|nmod|START_ENTITY responses|nmod|administrations responses|compound|END_ENTITY	Insulin responses to administrations of amino_acids and fatty_acids in healthy cats .
21984377	0	amino_acids	56,67	Insulin	0,7	amino acids	Insulin	CHEBI:33709	3630	Chemical	Gene	START_ENTITY|nsubj|resistance resistance|compound|END_ENTITY	Insulin resistance and the metabolism of branched-chain amino_acids in humans .
23385611	0	amino_acids	56,67	Insulin	0,7	amino acids	Insulin	CHEBI:33709	3630	Chemical	Gene	START_ENTITY|nsubj|resistance resistance|compound|END_ENTITY	Insulin resistance and the metabolism of branched-chain amino_acids .
3510558	0	amino_acids	44,55	Insulin	0,7	amino acids	Insulin	CHEBI:33709	3630	Chemical	Gene	START_ENTITY|nsubj|reductions reductions|amod|END_ENTITY	Insulin dose-dependent reductions in plasma amino_acids in man .
8626379	0	amino_acids	151,162	Insulin_receptor_substrate-2	0,28	amino acids	Insulin receptor substrate-2	CHEBI:33709	8660	Chemical	Gene	START_ENTITY|nsubj|binds binds|amod|END_ENTITY	Insulin_receptor_substrate-2 binds to the insulin_receptor through its phosphotyrosine-binding domain and through a newly identified domain comprising amino_acids 591-786 .
24406792	0	amino_acids	9,20	KAT2	74,78	amino acids	KAT2	CHEBI:33709	827555(Tax:3702)	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Distinct amino_acids in the C-linker domain of the Arabidopsis K + channel KAT2 determine its subcellular localization and activity at the plasma membrane .
1311310	3	amino_acids	345,356	LHR	318,321	amino acids	LHR	CHEBI:33709	16867(Tax:10090)	Chemical	Gene	protein|nmod|START_ENTITY END_ENTITY|dep|protein	This LHR -LRB- mature protein of 674 amino_acids -RRB- is very similar to that of the rat -LRB- same length , 36 amino_acid differences -RRB- but differs significantly more from that of man -LRB- 673 amino_acids , 109 differences -RRB- .
3552619	0	amino_acids	40,51	LHRH	11,15	amino acids	LHRH	CHEBI:33709	2796	Chemical	Gene	START_ENTITY|nsubj|Studies Studies|nmod|END_ENTITY	Studies on LHRH and physiological fluid amino_acids in human colostrum and milk .
24573245	0	amino_acids	81,92	LTA4H	57,62	amino acids	LTA4H	CHEBI:33709	4048	Chemical	Gene	activity|nmod|START_ENTITY activity|appos|END_ENTITY	A remarkable activity of human leukotriene_A4_hydrolase -LRB- LTA4H -RRB- toward unnatural amino_acids .
18096943	0	amino_acids	97,108	Milk	0,4	amino acids	Milk	CHEBI:33709	100532204	Chemical	Gene	concentration|nmod|START_ENTITY gland|nmod|concentration gland|nsubj|response response|compound|END_ENTITY	Milk synthetic response of the bovine mammary gland to an increase in the local concentration of amino_acids and acetate .
23190566	0	amino_acids	107,118	Myosin_heavy_chain_2A	0,21	amino acids	Myosin heavy chain 2A	CHEBI:33709	4620	Chemical	Gene	START_ENTITY|nsubj|expression expression|amod|END_ENTITY	Myosin_heavy_chain_2A and a-actin expression in human and murine skeletal muscles at feeding ; particularly amino_acids .
15716048	0	amino_acids	73,84	Ornithine_decarboxylase	0,23	amino acids	Ornithine decarboxylase	CHEBI:33709	4953	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|activity activity|amod|END_ENTITY	Ornithine_decarboxylase activity is inhibited by the polyamine precursor amino_acids at the protein stability level in Caco-2 cells .
10517803	0	amino_acids	18,29	P2X2	41,45	amino acids	P2X2	CHEBI:33709	114115(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	Identification of amino_acids within the P2X2 receptor C-terminus that regulate desensitization .
10479654	1	amino_acids	333,344	PI3K	301,305	amino acids	PI3K	CHEBI:33709	85243(Tax:10116)	Chemical	Gene	uptake|nmod|START_ENTITY END_ENTITY|nmod|uptake	Although accumulating evidence suggests that phosphatidylinositol_3-kinase -LRB- PI3K -RRB- is a common signaling molecule for growth factor-induced amino_acid uptake by the cell , the role of PI3K in the uptake of different amino_acids was not tested under the same conditions .
10025505	0	amino_acids	101,112	PSP94	61,66	amino acids	PSP94	CHEBI:33709	17695(Tax:10090)	Chemical	Gene	protein|nmod|START_ENTITY END_ENTITY|dep|protein	cDNA , genomic cloning , and gene expression analysis of mouse PSP94 -LRB- prostate secretory protein of 94 amino_acids -RRB- .
9136076	0	amino_acids	73,84	PSP94	33,38	amino acids	PSP94	CHEBI:33709	4477	Chemical	Gene	protein|nmod|START_ENTITY END_ENTITY|dep|protein	Analysis of epitope structure of PSP94 -LRB- prostate secretory protein of 94 amino_acids -RRB- : -LRB- I -RRB- .
15739410	0	amino_acids	17,28	PTH	13,16	amino acids	PTH	CHEBI:33709	5741	Chemical	Gene	START_ENTITY|nsubj|Analysis Analysis|nmod|END_ENTITY	-LSB- Analysis of PTH amino_acids by micellar electrokinetic capillary chromatography -RSB- .
17699255	2	amino_acids	394,405	PTH	413,416	amino acids	PTH	CHEBI:33709	5741	Chemical	Gene	more|nmod|START_ENTITY more|nmod|structure structure|compound|END_ENTITY	This can be accomplished by PTH measurements using third-generation PTH assays , which detect more or less of the first six amino_acids of the PTH structure .
2163325	0	amino_acids	107,118	PTH	53,56	amino acids	PTH	CHEBI:33709	5741	Chemical	Gene	substitution|nmod|START_ENTITY NH2|nmod|substitution NH2|nsubj|Removal Removal|nmod|agonism agonism|nmod|hormone hormone|appos|END_ENTITY	Removal of partial agonism from parathyroid hormone -LRB- PTH -RRB- - related protein - -LRB- 7-34 -RRB- NH2 by substitution of PTH amino_acids at positions 10 and 11 .
2184438	5	amino_acids	609,620	PTH	647,650	amino acids	PTH	CHEBI:33709	5741	Chemical	Gene	Eight|nmod|START_ENTITY identical|nsubj|Eight identical|nmod|END_ENTITY	Eight of the first 13 amino_acids were identical with human PTH , although antisera directed to the NH2-terminus of PTHrP do not recognize PTH ; this homology is not maintained in the remainder of the molecule .
8044024	0	amino_acids	54,65	PTH	50,53	amino acids	PTH	CHEBI:33709	5741	Chemical	Gene	START_ENTITY|nsubj|resolution resolution|nmod|END_ENTITY	Improved thin layer chromatographic resolution of PTH amino_acids with some new solvent systems .
26645192	0	amino_acids	89,100	PheRS	29,34	amino acids	PheRS	MESH:D000596	10056	Chemical	Gene	exhibits|nmod|START_ENTITY exhibits|nsubj|END_ENTITY	Chimeric human mitochondrial PheRS exhibits editing activity to discriminate non-protein amino_acids .
9259323	5	amino_acids	927,938	Pit-1	921,926	amino acids	Pit-1	CHEBI:33709	25517(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|deletion deletion|nmod|END_ENTITY	RIP140 inhibition is profoundly influenced , in a promoter-specific fashion , by a synergism-selective function in Pit-1 : deletion of Pit-1 amino_acids 72-100 switches RIP140 to an activator of Pit-1 / ER and Pit-1 / TR synergy at the rPRL promoter but not at the rGH promoter .
2732299	0	amino_acids	48,59	Prolactin	0,9	amino acids	Prolactin	CHEBI:33709	5617	Chemical	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|stimulation stimulation|compound|END_ENTITY	Prolactin stimulation by protein is mediated by amino_acids in humans .
24272750	6	amino_acids	780,791	Rcy1p	810,815	amino acids	Rcy1p	CHEBI:33709	853226(Tax:4932)	Chemical	Gene	region|amod|START_ENTITY region|nmod|END_ENTITY	The Drs2p-binding region was mapped to the amino_acids 574-778 region of Rcy1p and a mutant Rcy1p lacking this region was defective in endocytic recycling of a v-SNARE Snc1p .
7720856	0	amino_acids	87,98	Rep	106,109	amino acids	Rep	CHEBI:33709	949141(Tax:10832)	Chemical	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	DNA replication specificity of TYLCV geminivirus is mediated by the amino-terminal 116 amino_acids of the Rep protein .
16170341	0	amino_acids	39,50	Rheb	31,35	amino acids	Rheb	CHEBI:33709	6009	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of the small GTPase Rheb by amino_acids .
23863162	6	amino_acids	797,808	Rheb	629,633	amino acids	PLD1	CHEBI:33709	5337	Chemical	Gene	stimulates|nmod|START_ENTITY machinery|acl:relcl|stimulates part|nmod|machinery responsive|parataxis|part responsive|nsubj|END_ENTITY	Rheb is responsive to growth factors , but , in conjunction with PLD1 -LRB- phospholipase_D1 -RRB- , is also an integral part of the machinery that stimulates mTORC1 in response to amino_acids .
8260503	0	amino_acids	127,138	Rhodopsin	0,9	amino acids	Rhodopsin	CHEBI:33709	6010	Chemical	Gene	effects|nmod|START_ENTITY activation|dep|effects activation|compound|END_ENTITY	Rhodopsin activation : effects on the metarhodopsin I-metarhodopsin II equilibrium of neutralization or introduction of charged amino_acids within putative transmembrane segments .
21492481	0	amino_acids	61,72	SR-PSOX	25,32	amino acids	SR-PSOX	CHEBI:33709	58191	Chemical	Gene	modification|nmod|START_ENTITY modification|nmod|END_ENTITY	Function modification of SR-PSOX by point mutations of basic amino_acids .
15521922	0	amino_acids	22,33	TAFI	0,4	amino acids	TAFI	CHEBI:33709	1361	Chemical	Gene	polymorphisms|nmod|START_ENTITY polymorphisms|nummod|END_ENTITY	TAFI polymorphisms at amino_acids 147 and 325 are not risk factors for cerebral_infarction .
11448951	0	amino_acids	46,57	TNF	41,44	amino acids	TNF	CHEBI:33709	21926(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Identification Identification|appos|END_ENTITY	Identification of tumor_necrosis_factor -LRB- TNF -RRB- amino_acids crucial for binding to the murine p75 TNF receptor and construction of receptor-selective mutants .
15934319	0	amino_acids	61,72	TNF-alpha	105,114	amino acids	TNF-alpha	CHEBI:33709	24835(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|acl|induced induced|nmod|END_ENTITY	Effect of morphine and naloxone on release of the excitatory amino_acids of spinal astrocytes induced by TNF-alpha .
17174996	0	amino_acids	52,63	UDP-glucuronosyltransferase_1A10	110,142	amino acids	UDP-glucuronosyltransferase 1A10	CHEBI:33709	54575	Chemical	Gene	START_ENTITY|nmod|site site|nmod|END_ENTITY	Phenylalanine -LRB- 90 -RRB- and phenylalanine -LRB- 93 -RRB- are crucial amino_acids within the estrogen binding site of the human UDP-glucuronosyltransferase_1A10 .
19123921	0	amino_acids	27,38	WT1	106,109	amino acids	WT1	CHEBI:33709	7490	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	Contribution of individual amino_acids to the RNA binding activity of the Wilms ' _ tumor suppressor protein WT1 .
25451328	0	amino_acids	20,31	acetylcholinesterase	94,114	amino acids	acetylcholinesterase	CHEBI:33709	43	Chemical	Gene	START_ENTITY|nmod|reactivation reactivation|nmod|END_ENTITY	Probing the role of amino_acids in oxime-mediated reactivation of nerve agent-inhibited human acetylcholinesterase .
24379400	0	amino_acids	23,34	activating_transcription_factor_5	38,71	amino acids	activating transcription factor 5	CHEBI:33709	22809	Chemical	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	N-terminal hydrophobic amino_acids of activating_transcription_factor_5 -LRB- ATF5 -RRB- protein confer interleukin_1b -LRB- IL-1b -RRB- - induced stabilization .
9797030	0	amino_acids	67,78	adenosine_A1_receptor	82,103	amino acids	adenosine A1 receptor	CHEBI:33709	29290(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|agonist agonist|amod|END_ENTITY	Modulation of ischemia-evoked release of excitatory and inhibitory amino_acids by adenosine_A1_receptor agonist .
1156598	1	amino_acids	90,101	albumin	133,140	amino acids	albumin	CHEBI:33709	24186(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|synthesis synthesis|compound|END_ENTITY	The effects of amino_acids and adrenocortical steroids on albumin synthesis after partial hepatectomy .
6275391	0	amino_acids	36,47	albumin	63,70	amino acids	albumin	CHEBI:33709	213	Chemical	Gene	START_ENTITY|nmod|mRNA mRNA|compound|END_ENTITY	Nucleotide sequence and the encoded amino_acids of human serum albumin mRNA .
24358164	0	amino_acids	26,37	aldehyde_oxidase	47,63	amino acids	aldehyde oxidase	CHEBI:33709	11430(Tax:10090)	Chemical	Gene	Identification|nmod|START_ENTITY END_ENTITY|nsubj|Identification	Identification of crucial amino_acids in mouse aldehyde_oxidase 3 that determine substrate specificity .
7907590	0	amino_acids	3,14	alpha-subunit	61,74	amino acids	alpha-subunit	CHEBI:33709	395381(Tax:9031)	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	26 amino_acids of an extracellular domain of the Na,K-ATPase alpha-subunit are sufficient for assembly with the Na,K-ATPase beta-subunit .
11841622	0	amino_acids	11,22	aminopeptidase_a	53,69	amino acids	aminopeptidase a	CHEBI:33709	64017(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of amino_acids and glucose on mesangial cell aminopeptidase_a and angiotensin receptors .
6198645	0	amino_acids	36,47	apolipoprotein_A-I	57,75	amino acids	apolipoprotein A-I	CHEBI:33709	335	Chemical	Gene	START_ENTITY|nmod|mRNA mRNA|compound|END_ENTITY	Nucleotide sequence and the encoded amino_acids of human apolipoprotein_A-I mRNA .
14561230	0	amino_acids	7,18	aquaporin-1	54,65	amino acids	aquaporin-1	CHEBI:33709	358	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Single amino_acids in the carboxyl terminal domain of aquaporin-1 contribute to cGMP-dependent ion channel activation .
7823029	0	amino_acids	55,66	as_D	112,116	amino acids	as D	CHEBI:33709	414	Chemical	Gene	transport|nmod|START_ENTITY END_ENTITY|nsubj|transport	Special transport and neurological significance of two amino_acids in a configuration conventionally designated as_D .
19286660	0	amino_acids	106,117	bleomycin_hydrolase	26,45	amino acids	bleomycin hydrolase	CHEBI:33709	287552(Tax:10116)	Chemical	Gene	essential|nmod|START_ENTITY essential|nsubj|END_ENTITY	Neutral cysteine protease bleomycin_hydrolase is essential for the breakdown of deiminated filaggrin into amino_acids .
2565783	0	amino_acids	47,58	cholecystokinin	20,35	amino acids	cholecystokinin	CHEBI:33709	414884(Tax:9031)	Chemical	Gene	release|nmod|START_ENTITY release|nmod|END_ENTITY	Enhanced release of cholecystokinin by dietary amino_acids in chicks -LRB- Gallus_domesticus -RRB- .
8844480	0	amino_acids	35,46	cholecystokinin	50,65	amino acids	cholecystokinin	CHEBI:33709	885	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	Effects of intravenous infusion of amino_acids on cholecystokinin release and gallbladder contraction in humans .
1381349	0	amino_acids	54,65	cholesteryl_ester_transfer_protein	69,103	amino acids	cholesteryl ester transfer protein	CHEBI:33709	1071	Chemical	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of a sequence within the C-terminal 26 amino_acids of cholesteryl_ester_transfer_protein responsible for binding a neutralizing monoclonal antibody and necessary for neutral lipid transfer activity .
23470256	0	amino_acids	18,29	colipase	39,47	amino acids	colipase	CHEBI:33709	1208	Chemical	Gene	Identification|nmod|START_ENTITY END_ENTITY|nsubj|Identification	Identification of amino_acids in human colipase that mediate adsorption to lipid emulsions and mixed micelles .
1197382	0	amino_acids	45,56	cystathionine-gamma-lyase	70,95	amino acids	cystathionine-gamma-lyase	CHEBI:33709	24962(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of several unusual sulfur-containing amino_acids on rat liver cystathionine-gamma-lyase .
1652100	0	amino_acids	22,33	ecotropic_retrovirus_receptor	47,76	amino acids	ecotropic retrovirus receptor	CHEBI:33709	11987(Tax:10090)	Chemical	Gene	Transport|nmod|START_ENTITY Transport|nmod|END_ENTITY	Transport of cationic amino_acids by the mouse ecotropic_retrovirus_receptor .
8702724	0	amino_acids	18,29	estrogen_receptor	73,90	amino acids	estrogen receptor	CHEBI:33709	2099	Chemical	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of amino_acids in the hormone binding domain of the human estrogen_receptor important in estrogen binding .
9439598	0	amino_acids	120,131	furin	69,74	amino acids	furin	CHEBI:33709	18550(Tax:10090)	Chemical	Gene	site|nmod|START_ENTITY site|amod|END_ENTITY	Maturation of secreted meprin_alpha during biosynthesis : role of the furin site and identification of the COOH-terminal amino_acids of the mouse kidney metalloprotease subunit .
219249	0	amino_acids	135,146	gag	154,157	amino acids	gag	CHEBI:33709	1491923(Tax:11886)	Chemical	Gene	START_ENTITY|nmod|product product|compound|END_ENTITY	In vitro , the major ribosome binding site on Rous_sarcoma_virus RNA does not contain the nucleotide sequence coding for the N-terminal amino_acids of the gag gene product .
12970386	0	amino_acids	14,25	gastrin-releasing_Peptide_receptor	89,123	amino acids	gastrin-releasing Peptide receptor	CHEBI:33709	2925	Chemical	Gene	Importance|nmod|START_ENTITY Importance|nmod|END_ENTITY	Importance of amino_acids of the central portion of the second intracellular loop of the gastrin-releasing_Peptide_receptor for phospholipase C activation , internalization , and chronic down-regulation .
16978155	0	amino_acids	43,54	gp120	76,81	amino acids	gp120	CHEBI:33709	155971(Tax:11676)	Chemical	Gene	Determination|nmod|START_ENTITY END_ENTITY|nsubj|Determination	Determination of structurally conservative amino_acids of the HIV-1 protein gp120 V3 loop as promising targets for drug design by protein engineering approaches .
8845955	0	amino_acids	72,83	gp120	17,22	amino acids	gp120	CHEBI:33709	155971(Tax:11676)	Chemical	Gene	uptake|nmod|START_ENTITY inhibits|dobj|uptake inhibits|nsubj|END_ENTITY	The coat protein gp120 of HIV-1 inhibits astrocyte uptake of excitatory amino_acids via macrophage arachidonic_acid .
19932886	0	amino_acids	108,119	granulocyte_colony-stimulating_factor	35,72	amino acids	granulocyte colony-stimulating factor	CHEBI:33709	25610(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY END_ENTITY|nmod|release	Suppressive effects of intrathecal granulocyte_colony-stimulating_factor on excessive release of excitatory amino_acids in the spinal cerebrospinal fluid of rats with cord_ischemia : role of glutamate transporters .
11174018	0	amino_acids	45,56	growth_hormone	78,92	amino acids	growth hormone	CHEBI:33709	81668(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|regulation regulation|nmod|secretion secretion|amod|END_ENTITY	Cross-talk between excitatory and inhibitory amino_acids in the regulation of growth_hormone secretion in neonatal rats .
7736696	0	amino_acids	78,89	growth_hormone	44,58	amino acids	growth hormone	CHEBI:33709	2688	Chemical	Gene	flux|nmod|START_ENTITY END_ENTITY|nmod|flux	Effects of insulin-like growth factor-I and growth_hormone on the net flux of amino_acids across the hind limbs in the surgically traumatized pig .
17071947	4	amino_acids	863,874	hHB-EGF	915,922	amino acids	hHB-EGF	CHEBI:33709	1839	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	To create novel DT receptors that are defective in growth factor activity and resistant to metalloprotease-cleavage , we mutated five amino_acids in the extracellular EGF-like domain of hHB-EGF , which contains both DT-binding and protease-cleavage sites .
9191105	0	amino_acids	133,144	heat-shock_protein	13,31	amino acids	heat-shock protein	CHEBI:33709	24472(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Induction Induction|nmod|END_ENTITY	Induction of heat-shock_protein -LRB- HSP72 -RRB- in the cingulate and retrosplenial cortex by drugs that antagonize the effects of excitatory amino_acids .
2501657	4	amino_acids	528,539	human	543,548	amino acids	rhoH6	CHEBI:33709	388	Chemical	Gene	START_ENTITY|nmod|protein protein|amod|END_ENTITY	The predicted 193 amino_acids of human rhoH12 protein show 88 % similarity with those of the human rhoH6 clone , 96.8 % similarity with those of the Aplysia rho product , and 81.8 % similarity with those of the yeast RHO1 protein .
12387335	0	amino_acids	52,63	hypoglycin_A	117,129	amino acids	hypoglycin A	CHEBI:33709	55660	Chemical	Gene	analysis|nmod|START_ENTITY analysis|nmod|END_ENTITY	High-performance liquid chromatographic analysis of amino_acids in ackee fruit with emphasis on the toxic amino_acid hypoglycin_A .
12006361	0	amino_acids	75,86	insulin	19,26	amino acids	insulin	CHEBI:33709	100009181(Tax:9986)	Chemical	Gene	augmented|nmod|START_ENTITY wound|ccomp|augmented wound|nsubj|action action|nmod|END_ENTITY	Anabolic action of insulin on skin wound protein is augmented by exogenous amino_acids .
12183515	0	amino_acids	100,111	insulin	24,31	amino acids	insulin	CHEBI:33709	3630	Chemical	Gene	muscle|nmod|START_ENTITY synthesis|nmod|muscle control|nmod|synthesis END_ENTITY|nmod|control	Invited Review : Role of insulin in translational control of protein synthesis in skeletal muscle by amino_acids or exercise .
1415525	0	amino_acids	71,82	insulin	99,106	amino acids	insulin	CHEBI:33709	397415(Tax:9823)	Chemical	Gene	START_ENTITY|nmod|availability availability|compound|END_ENTITY	Stimulation of protein synthesis in pig skeletal muscle by infusion of amino_acids during constant insulin availability .
14656717	0	amino_acids	16,27	insulin	7,14	amino acids	insulin	CHEBI:33709	3630	Chemical	Gene	stimulate|nsubj|START_ENTITY stimulate|nmod|END_ENTITY	Unlike insulin , amino_acids stimulate p70S6K but not GSK-3 or glycogen_synthase in human skeletal muscle .
15442897	0	amino_acids	29,40	insulin	54,61	amino acids	insulin	CHEBI:33709	3630	Chemical	Gene	analysis|nmod|START_ENTITY analysis|dep|END_ENTITY	The quantitative analysis of amino_acids in proteins : insulin and lysozyme .
1635346	0	amino_acids	59,70	insulin	10,17	amino acids	insulin	CHEBI:33709	3630	Chemical	Gene	response|nmod|START_ENTITY Effect|nmod|response Effect|nmod|therapy therapy|compound|END_ENTITY	Effect of insulin therapy on renal hemodynamic response to amino_acids and renal_hypertrophy in non-insulin-dependent_diabetes .
16843315	0	amino_acids	60,71	insulin	13,20	amino acids	insulin	CHEBI:33709	3630	Chemical	Gene	START_ENTITY|nsubj|Influence Influence|nmod|END_ENTITY	Influence of insulin on peripheral uptake of branched chain amino_acids in the 60-hour fasted state .
1728720	0	amino_acids	58,69	insulin	11,18	amino acids	insulin	CHEBI:33709	3630	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of insulin on myocardial uptake of branched chain amino_acids soon after cardiac operations .
19929783	0	amino_acids	15,26	insulin	124,131	amino acids	insulin	CHEBI:33709	3630	Chemical	Gene	START_ENTITY|dep|agents agents|nmod|resistance resistance|compound|END_ENTITY	Branched-chain amino_acids and pigment epithelium-derived factor : novel therapeutic agents for hepatitis_c_virus-associated insulin resistance .
21525255	0	amino_acids	10,21	insulin	97,104	amino acids	insulin	CHEBI:33709	280829(Tax:9913)	Chemical	Gene	START_ENTITY|xcomp|regulate regulate|dobj|initiation initiation|nmod|independent independent|nmod|END_ENTITY	Essential amino_acids regulate both initiation and elongation of mRNA translation independent of insulin in MAC-T cells and bovine mammary tissue slices .
2193532	0	amino_acids	35,46	insulin	8,15	amino acids	insulin	CHEBI:33709	3630	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of insulin and branched-chain amino_acids in regulating protein metabolism during fasting .
22560213	0	amino_acids	44,55	insulin	74,81	amino acids	insulin	CHEBI:33709	3630	Chemical	Gene	START_ENTITY|nmod|development development|nmod|resistance resistance|compound|END_ENTITY	Interplay between lipids and branched-chain amino_acids in development of insulin resistance .
24130332	0	amino_acids	60,71	insulin	94,101	amino acids	insulin	CHEBI:33709	3630	Chemical	Gene	START_ENTITY|nmod|action action|compound|END_ENTITY	BMI , RQ , diabetes , and sex affect the relationships between amino_acids and clamp measures of insulin action in humans .
24747859	0	amino_acids	79,90	insulin	101,108	amino acids	insulin	CHEBI:33709	280829(Tax:9913)	Chemical	Gene	study|nmod|START_ENTITY supported|dobj|study supported|nmod|END_ENTITY	Quantum-mechanical DFT calculation supported Raman spectroscopic study of some amino_acids in bovine insulin .
2644251	1	amino_acids	85,96	insulin	113,120	amino acids	insulin	CHEBI:33709	3630	Chemical	Gene	ability|nmod|START_ENTITY Selective|dobj|ability Selective|advcl|enhance enhance|dobj|sensitivity sensitivity|compound|END_ENTITY	Selective ability of amino_acids to enhance both insulin sensitivity and maximal insulin responsiveness of the protein synthesis system .
26575335	0	amino_acids	24,35	insulin	101,108	amino acids	insulin	MESH:D000596	483665(Tax:9615)	Chemical	Gene	infusion|nmod|START_ENTITY attenuates|nsubj|infusion attenuates|nmod|secretion secretion|compound|END_ENTITY	Intravenous infusion of amino_acids in dogs attenuates hypothermia during anaesthesia and stimulates insulin secretion .
3312939	0	amino_acids	129,140	insulin	94,101	amino acids	insulin	CHEBI:33709	3630	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Insulin resistance in aged man : relationship between impaired_glucose_tolerance and decreased insulin activity on branched-chain amino_acids .
3521757	0	amino_acids	99,110	insulin	71,78	amino acids	insulin	CHEBI:33709	3630	Chemical	Gene	action|nmod|START_ENTITY action|compound|END_ENTITY	2-ketoglutarate generation in pancreatic B-cell mitochondria regulates insulin secretory action of amino_acids and 2-keto_acids .
3888496	0	amino_acids	17,28	insulin	45,52	amino acids	insulin	CHEBI:33709	483665(Tax:9615)	Chemical	Gene	Changes|nmod|START_ENTITY account|nsubj|Changes account|nmod|responses responses|compound|END_ENTITY	Changes in blood amino_acids account for the insulin and glucagon responses to mixed meals in dogs .
4287739	0	amino_acids	69,80	insulin	38,45	amino acids	insulin	CHEBI:33709	3630	Chemical	Gene	START_ENTITY|nsubj|observations observations|nmod|influence influence|nmod|END_ENTITY	Some observations on the influence of insulin , prednisolone and free amino_acids on the glucose metabolism in cultivated liver tissue .
4569911	0	amino_acids	31,42	insulin	70,77	amino acids	insulin	CHEBI:33709	3630	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|release release|nmod|END_ENTITY	Effects of neutral and dibasic amino_acids on the in vitro release of insulin .
624443	0	amino_acids	37,48	insulin	8,15	amino acids	insulin	CHEBI:33709	3630	Chemical	Gene	ingested|dobj|START_ENTITY Loss|acl|ingested Loss|nmod|response response|compound|END_ENTITY	Loss of insulin response to ingested amino_acids after jejunoileal bypass surgery for morbid obesity .
6339351	0	amino_acids	73,84	insulin	21,28	amino acids	insulin	CHEBI:33709	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|infusion infusion|compound|END_ENTITY	Effect of euglycemic insulin infusion on plasma levels of branched-chain amino_acids in cirrhosis .
640239	0	amino_acids	21,32	insulin	36,43	amino acids	insulin	CHEBI:33709	3630	Chemical	Gene	START_ENTITY|nmod|response response|compound|END_ENTITY	Effect of priming of amino_acids on insulin and growth_hormone response in the premature infant .
7001633	2	amino_acids	401,412	insulin	233,240	amino acids	insulin	CHEBI:33709	3630	Chemical	Gene	peptide|dep|START_ENTITY encoding|nmod|peptide RNA|xcomp|encoding larger|advcl|RNA larger|nsubj|RNA RNA|compound|END_ENTITY	Fish insulin messenger RNA is larger -LRB- 1.5 times -RRB- than the messenger RNA encoding mammalian -LRB- rat and human -RRB- insulin , in part because of a larger C peptide -LRB- an additional six amino_acids or 18 nucleotides in length -RRB- but mainly because of increases in the 5 ' and 3 ' untranslated regions .
7006941	0	amino_acids	49,60	insulin	11,18	amino acids	insulin	CHEBI:33709	483665(Tax:9615)	Chemical	Gene	uptake|nmod|START_ENTITY Effects|nmod|uptake Effects|nmod|END_ENTITY	Effects of insulin and glucagon on the uptake of amino_acids from arterial blood by canine ileum .
71038	0	amino_acids	17,28	insulin	80,87	amino acids	insulin	CHEBI:33709	100009181(Tax:9986)	Chemical	Gene	Incorporation|nmod|START_ENTITY Incorporation|dep|effect effect|nmod|END_ENTITY	Incorporation of amino_acids into protein of foetal rabbit diaphragm : effect of insulin .
7616165	0	amino_acids	32,43	insulin	207,214	amino acids	insulin	CHEBI:33709	105613195	Chemical	Gene	mixture|nmod|START_ENTITY increases|nsubj|mixture increases|advcl|infused infused|nmod|phase phase|nmod|cycle cycle|dep|effect effect|acl:relcl|mediated mediated|nmod|END_ENTITY	A mixture of the branched chain amino_acids leucine , isoleucine and valine increases ovulation rate in ewes when infused during the late luteal phase of the oestrous cycle : an effect that may be mediated by insulin .
8347381	0	amino_acids	27,38	insulin	11,18	amino acids	insulin	CHEBI:33709	3630	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of insulin on free amino_acids in plasma and the role of the amino_acid metabolism in the etiology of diabetic_microangiopathy .
9439551	0	amino_acids	83,94	insulin	19,26	amino acids	insulin	CHEBI:33709	3630	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|stimulation stimulation|nmod|END_ENTITY	The stimulation of insulin secretion in non-insulin-dependent diabetic patients by amino_acids and gliclazide in the basal and hyperglycemic state .
10915640	0	amino_acids	32,43	insulin-like_growth_factor-I	77,105	amino acids	insulin-like growth factor-I	CHEBI:33709	24482(Tax:10116)	Chemical	Gene	transport|nmod|START_ENTITY transport|dep|effect effect|nmod|END_ENTITY	Altered intestinal transport of amino_acids in cirrhotic rats : the effect of insulin-like_growth_factor-I .
11110845	0	amino_acids	40,51	insulin-like_growth_factor-I	67,95	amino acids	insulin-like growth factor-I	CHEBI:33709	24482(Tax:10116)	Chemical	Gene	restriction|nmod|START_ENTITY reduces|nsubj|restriction reduces|dobj|END_ENTITY	Dietary restriction of single essential amino_acids reduces plasma insulin-like_growth_factor-I -LRB- IGF-I -RRB- but does not affect plasma IGF-binding_protein-1 in rats .
7511786	0	amino_acids	125,136	insulin-like_growth_factor-I	14,42	amino acids	insulin-like growth factor-I	CHEBI:33709	24482(Tax:10116)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of insulin-like_growth_factor-I -LRB- IGF-I -RRB- and IGF-binding_protein_1 gene transcription by hormones and provision of amino_acids in rat hepatocytes .
1600937	0	amino_acids	33,44	interleukin-2_receptor_beta	48,75	amino acids	interleukin-2 receptor beta	CHEBI:33709	3560	Chemical	Gene	START_ENTITY|nmod|chain chain|amod|END_ENTITY	Identification of three adjacent amino_acids of interleukin-2_receptor_beta chain which control the affinity and the specificity of the interaction with interleukin-2 .
24573245	0	amino_acids	81,92	leukotriene_A4_hydrolase	31,55	amino acids	leukotriene A4 hydrolase	CHEBI:33709	4048	Chemical	Gene	activity|nmod|START_ENTITY activity|nmod|END_ENTITY	A remarkable activity of human leukotriene_A4_hydrolase -LRB- LTA4H -RRB- toward unnatural amino_acids .
8642267	0	amino_acids	9,20	lymphocyte_function-associated_antigen-1	28,68	amino acids	lymphocyte function-associated antigen-1	CHEBI:33709	3683	Chemical	Gene	START_ENTITY|nmod|domain domain|amod|END_ENTITY	Critical amino_acids in the lymphocyte_function-associated_antigen-1 I domain mediate intercellular_adhesion_molecule_3 binding and immune function .
21769869	0	amino_acids	15,26	mTORC1	114,120	amino acids	mTORC1	CHEBI:33709	382056(Tax:10090)	Chemical	Gene	prevent|nsubj|START_ENTITY prevent|advcl|inducing inducing|nmod|mechanisms mechanisms|amod|END_ENTITY	Branched-chain amino_acids prevent insulin-induced hepatic_tumor cell proliferation by inducing apoptosis through mTORC1 and mTORC2-dependent mechanisms .
21785113	0	amino_acids	43,54	mTORC1	26,32	amino acids	mTORC1	CHEBI:33709	382056(Tax:10090)	Chemical	Gene	system|nmod|START_ENTITY system|amod|END_ENTITY	Spatial regulation of the mTORC1 system in amino_acids sensing pathway .
21981914	0	amino_acids	29,40	mTORC1	44,50	amino acids	mTORC1	CHEBI:33709	382056(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	A new link in the chain from amino_acids to mTORC1 activation .
22053050	0	amino_acids	24,35	mTORC1	0,6	amino acids	mTORC1	CHEBI:33709	382056(Tax:10090)	Chemical	Gene	lysosomal|dobj|START_ENTITY lysosomal|nsubj|senses senses|amod|END_ENTITY	mTORC1 senses lysosomal amino_acids through an inside-out mechanism that requires the vacuolar H -LRB- + -RRB- - ATPase .
22566039	0	amino_acids	73,84	mTORC1	21,27	amino acids	mTORC1	CHEBI:33709	382056(Tax:10090)	Chemical	Gene	content|nmod|START_ENTITY independent|nmod|content independent|amod|END_ENTITY	Glutamine stimulates mTORC1 independent of the cell content of essential amino_acids .
22898570	0	amino_acids	22,33	mTORC1	42,48	amino acids	mTORC1	CHEBI:33709	382056(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Cellular signaling of amino_acids towards mTORC1 activation in impaired human leucine catabolism .
23263183	11	amino_acids	1709,1720	mTORC1	1785,1791	amino acids	mTORC1	CHEBI:33709	382056(Tax:10090)	Chemical	Gene	controls|nmod|START_ENTITY controls|nmod|surface surface|appos|site site|nmod|activation activation|amod|END_ENTITY	Indeed , mTORC1 is resistant to glucose deprivation in RagA -LRB- GTP/GTP -RRB- fibroblasts , and glucose , like amino_acids , controls its recruitment to the lysosomal surface , the site of mTORC1 activation .
24698685	0	amino_acids	24,35	mTORC1	14,20	amino acids	mTORC1	CHEBI:33709	382056(Tax:10090)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of mTORC1 by amino_acids .
25701492	0	amino_acids	31,42	mTORC1	56,62	amino acids	mTORC1	CHEBI:33709	382056(Tax:10090)	Chemical	Gene	START_ENTITY|xcomp|signaling signaling|nmod|activation activation|amod|END_ENTITY	Key mediators of intracellular amino_acids signaling to mTORC1 activation .
27053525	0	amino_acids	65,76	mTORC1	14,20	amino acids	mTORC1	MESH:D000596	382056(Tax:10090)	Chemical	Gene	potentiated|nmod|START_ENTITY potentiated|nsubjpass|Activation Activation|nmod|END_ENTITY	Activation of mTORC1 by leucine is potentiated by branched chain amino_acids and even more so by essential amino_acids following resistance exercise .
17545153	0	amino_acids	30,41	melanocortin-4_receptor	49,72	amino acids	melanocortin-4 receptor	CHEBI:33709	4160	Chemical	Gene	START_ENTITY|nmod|-RSB- -RSB-|amod|END_ENTITY	Contribution of the conserved amino_acids of the melanocortin-4_receptor in -LSB- corrected -RSB- -LSB- Nle4,D-Phe7 -RSB- - alpha-melanocyte-stimulating -LSB- corrected -RSB- hormone binding and signaling .
9457761	0	amino_acids	65,76	methemoglobin	13,26	amino acids	methemoglobin	CHEBI:33709	3048	Chemical	Gene	Reduction|nmod|START_ENTITY Reduction|nmod|END_ENTITY	Reduction of methemoglobin and ferricytochrome c by glycosylated amino_acids and albumin .
2846070	0	amino_acids	13,24	myeloperoxidase	55,70	amino acids	myeloperoxidase	CHEBI:33709	4353	Chemical	Gene	Oxidation|nmod|START_ENTITY Oxidation|nmod|END_ENTITY	Oxidation of amino_acids and peptides in reaction with myeloperoxidase , chloride and hydrogen_peroxide .
8567631	1	amino_acids	162,173	myeloperoxidase	201,216	amino acids	myeloperoxidase	CHEBI:33709	4353	Chemical	Gene	conversion|nmod|START_ENTITY mechanism|nmod|conversion aldehydes|nsubj|mechanism aldehydes|nmod|END_ENTITY	A_chloride-dependent mechanism for the conversion of free amino_acids into reactive aldehydes by myeloperoxidase .
10713102	0	amino_acids	5,16	nerve_growth_factor	45,64	amino acids	nerve growth factor	CHEBI:33709	4803	Chemical	Gene	START_ENTITY|dobj|specificity specificity|nmod|END_ENTITY	TrkA amino_acids controlling specificity for nerve_growth_factor .
25933935	0	amino_acids	123,134	neuropeptide_Y	31,45	amino acids	neuropeptide Y	CHEBI:33709	396464(Tax:9031)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Acute heat_stress up-regulates neuropeptide_Y precursor mRNA expression and alters brain and plasma concentrations of free amino_acids in chicks .
10421389	0	amino_acids	108,119	ornithine_decarboxylase	58,81	amino acids	ornithine decarboxylase	CHEBI:33709	24609(Tax:10116)	Chemical	Gene	intestinal|nmod|START_ENTITY intestinal|dobj|activity activity|amod|END_ENTITY	Whole-protein-based enteral formula stimulates intestinal ornithine_decarboxylase activity more than single amino_acids but does not affect mucosal adenosine_triphosphate content in early postsurgical refeeding .
3970979	0	amino_acids	48,59	ornithine_decarboxylase	131,154	amino acids	ornithine decarboxylase	CHEBI:33709	4953	Chemical	Gene	effects|nmod|START_ENTITY Comparison|nmod|effects analogs|nsubj|Comparison analogs|nmod|activity activity|compound|END_ENTITY	Comparison of the inhibitory effects of diverse amino_acids and amino_acid analogs on 12-O-tetradecanoylphorbol-13-acetate-induced ornithine_decarboxylase activity in isolated epidermal cells .
6249374	0	amino_acids	50,61	ornithine_decarboxylase	14,37	amino acids	ornithine decarboxylase	CHEBI:33709	4953	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Regulation of ornithine_decarboxylase activity by amino_acids , cyclic_AMP and luteinizing hormone in cultured mammalian cells .
1658623	0	amino_acids	84,95	p21	80,83	amino acids	p21	CHEBI:33709	644914	Chemical	Gene	START_ENTITY|nsubj|identification identification|nmod|END_ENTITY	The bovine papillomavirus E5 oncogene can cooperate with ras : identification of p21 amino_acids critical for transformation by c-rasH but not v-rasH .
3328019	0	amino_acids	9,20	p21	24,27	amino acids	p21	CHEBI:33709	644914	Chemical	Gene	START_ENTITY|nmod|protein protein|amod|END_ENTITY	Critical amino_acids of p21 protein are located within beta-turns : further evaluation .
14690553	0	amino_acids	64,75	p53	22,25	amino acids	p53	CHEBI:33709	7157	Chemical	Gene	effect|dep|START_ENTITY effect|nmod|END_ENTITY	-LSB- Inhibitory effect of p53 with deletion of c-terminal 356 - 393 amino_acids on malignant phenotype of human lung_cancer cell line -RSB- .
7174661	0	amino_acids	15,26	phenylalanine_hydroxylase	60,85	amino acids	phenylalanine hydroxylase	CHEBI:33709	24616(Tax:10116)	Chemical	Gene	Specificity|nmod|START_ENTITY Specificity|nmod|END_ENTITY	Specificity of amino_acids as activators and substrates for phenylalanine_hydroxylase .
11997389	0	amino_acids	10,21	phosphoenolpyruvate_carboxykinase	94,127	amino acids	phosphoenolpyruvate carboxykinase	CHEBI:33709	5106	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|amod|END_ENTITY	Conserved amino_acids within CCAAT enhancer-binding proteins -LRB- C/EBP -LRB- alpha -RRB- _ and_beta -RRB- regulate phosphoenolpyruvate_carboxykinase -LRB- PEPCK -RRB- gene expression .
123919	0	amino_acids	49,60	phospholipase_A	10,25	amino acids	phospholipase A	CHEBI:33709	57110	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of phospholipase_A on active transport of amino_acids with membrane vesicles of Mycobacterium phlei .
8702889	0	amino_acids	36,47	phospholipase_C-beta1	134,155	amino acids	phospholipase C-beta1	CHEBI:33709	24654(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of carboxyl-terminal basic amino_acids in Gqalpha-dependent activation , particulate association , and nuclear localization of phospholipase_C-beta1 .
9417098	0	amino_acids	29,40	phospholipase_C-delta1	78,100	amino acids	phospholipase C-delta1	CHEBI:33709	5333	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Replacements of single basic amino_acids in the pleckstrin homology domain of phospholipase_C-delta1 alter the ligand binding , phospholipase activity , and interaction with the plasma membrane .
7993895	0	amino_acids	18,29	phospholipase_C_gamma_1	62,85	amino acids	phospholipase C gamma 1	CHEBI:33709	5335	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Identification of amino_acids in the N-terminal SH2 domain of phospholipase_C_gamma_1 important in the interaction with epidermal_growth_factor_receptor .
150862	0	amino_acids	44,55	plasmin	91,98	amino acids	plasmin	CHEBI:33709	5340	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	Allosteric effects of some antifibrinolytic amino_acids on the catalytic activity of human plasmin .
14722235	0	amino_acids	18,29	pregnane_X_receptor	37,56	amino acids	pregnane X receptor	CHEBI:33709	84385(Tax:10116)	Chemical	Gene	Identification|nmod|START_ENTITY END_ENTITY|nsubj|Identification	Identification of amino_acids in rat pregnane_X_receptor that determine species-specific activation .
18088603	0	amino_acids	16,27	prion_protein	63,76	amino acids	prion protein	CHEBI:33709	19122(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	The deletion of amino_acids 114-121 in the TM1 domain of mouse prion_protein stabilizes its conformation but does not affect the overall structure .
1347633	0	amino_acids	26,37	proenkephalin	41,54	amino acids	proenkephalin	CHEBI:33709	29237(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	The effects of excitatory amino_acids on proenkephalin and prodynorphin mRNA levels in the hippocampal dentate gyrus of the rat ; an in situ hybridization study .
16388120	0	amino_acids	45,56	prolactin	11,20	amino acids	prolactin	CHEBI:33709	24683(Tax:10116)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Control Control|nmod|END_ENTITY	Control of prolactin secretion by excitatory amino_acids .
2307734	0	amino_acids	122,133	prolactin	72,81	amino acids	prolactin	CHEBI:33709	5617	Chemical	Gene	interaction|nmod|START_ENTITY Evidence|dep|interaction Evidence|nmod|action action|nmod|phenylalanine phenylalanine|nmod|stimulation stimulation|nmod|secretion secretion|compound|END_ENTITY	Evidence for an intracerebral action of phenylalanine in stimulation of prolactin secretion : interaction of large neutral amino_acids .
425782	0	amino_acids	17,28	prolactin	49,58	amino acids	prolactin	CHEBI:33709	5617	Chemical	Gene	influence|nmod|START_ENTITY influence|nmod|release release|compound|END_ENTITY	The influence of amino_acids and somatostatin on prolactin and growth_hormone release in man .
4297	0	amino_acids	31,42	prolactin	46,55	amino acids	prolactin	CHEBI:33709	24683(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|secretion secretion|compound|END_ENTITY	The effects of neurally active amino_acids on prolactin secretion .
15530480	0	amino_acids	11,22	prolidase	46,55	amino acids	prolidase	CHEBI:33709	5184	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|amod|END_ENTITY	Effects of amino_acids and its metabolites on prolidase activity against various iminodipeptides in erythrocytes from normal human and a patient with prolidase_deficiency .
11601970	0	amino_acids	102,113	rhodopsin	71,80	amino acids	rhodopsin	CHEBI:33709	6010	Chemical	Gene	proximities|nmod|START_ENTITY Probing|dep|proximities Probing|nmod|domain domain|nmod|END_ENTITY	Probing the dark state tertiary structure in the cytoplasmic domain of rhodopsin : proximities between amino_acids deduced from spontaneous disulfide bond formation between Cys316 and engineered cysteines in cytoplasmic loop 1 .
11601971	0	amino_acids	102,113	rhodopsin	71,80	amino acids	rhodopsin	CHEBI:33709	6010	Chemical	Gene	proximities|nmod|START_ENTITY proximities|dep|Probing Probing|nmod|domain domain|nmod|END_ENTITY	Probing the dark state tertiary structure in the cytoplasmic domain of rhodopsin : proximities between amino_acids deduced from spontaneous disulfide bond formation between cysteine pairs engineered in cytoplasmic loops 1 , 3 , and 4 .
11859928	0	amino_acids	109,120	rhodopsin	147,156	amino acids	rhodopsin	CHEBI:33709	6010	Chemical	Gene	equivalent|nmod|START_ENTITY motif|xcomp|equivalent motif|nmod|motif motif|nmod|family family|compound|END_ENTITY	Characterization of a G protein coupling `` YL '' motif of the human VPAC1_receptor , equivalent to the first two amino_acids in the `` DRY '' motif of the rhodopsin family .
15123809	0	amino_acids	23,34	rhodopsin	47,56	amino acids	rhodopsin	CHEBI:33709	6010	Chemical	Gene	START_ENTITY|xcomp|stabilizing stabilizing|dobj|END_ENTITY	Identification of core amino_acids stabilizing rhodopsin .
1577792	0	amino_acids	33,44	rhodopsin	84,93	amino acids	rhodopsin	CHEBI:33709	6010	Chemical	Gene	Introduction|nmod|START_ENTITY causes|nsubj|Introduction causes|dobj|shifts shifts|nmod|END_ENTITY	Introduction of hydroxyl-bearing amino_acids causes bathochromic spectral shifts in rhodopsin .
16922606	0	amino_acids	53,64	rhodopsin	40,49	amino acids	rhodopsin	CHEBI:33709	6010	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|END_ENTITY	Modulation of the absorption maximum of rhodopsin by amino_acids in the C-terminus .
17322302	0	amino_acids	47,58	rhodopsin	107,116	amino acids	rhodopsin	CHEBI:33709	6010	Chemical	Gene	role|nmod|START_ENTITY role|nmod|properties properties|amod|END_ENTITY	Critical role of electrostatic interactions of amino_acids at the cytoplasmic region of helices 3 and 6 in rhodopsin conformational properties and activation .
1999419	0	amino_acids	15,26	rhodopsin	109,118	amino acids	rhodopsin	CHEBI:33709	509933(Tax:9913)	Chemical	Gene	Mapping|nmod|START_ENTITY Mapping|nmod|helices helices|acl:relcl|interact interact|nmod|chromophore chromophore|nmod|END_ENTITY	Mapping of the amino_acids in membrane-embedded helices that interact with the retinal chromophore in bovine rhodopsin .
21114958	0	amino_acids	12,23	rhodopsin	70,79	amino acids	rhodopsin	CHEBI:33709	6010	Chemical	Gene	START_ENTITY|nmod|ends ends|nmod|helices helices|nmod|END_ENTITY	Hydrophobic amino_acids at the cytoplasmic ends of helices 3 and 6 of rhodopsin conjointly modulate transducin activation .
23332697	0	amino_acids	24,35	rhodopsin	73,82	amino acids	rhodopsin	CHEBI:33709	6010	Chemical	Gene	role|nmod|START_ENTITY role|nmod|structure structure|nmod|family family|compound|END_ENTITY	The role of hydrophobic amino_acids in the structure and function of the rhodopsin family of G protein-coupled receptors .
7612621	0	amino_acids	15,26	rhodopsin	81,90	amino acids	rhodopsin	CHEBI:33709	6010	Chemical	Gene	Mapping|nmod|START_ENTITY helices|nsubj|Mapping helices|dobj|C C|nmod|END_ENTITY	Mapping of the amino_acids in the cytoplasmic loop connecting helices C and D in rhodopsin .
7957262	0	amino_acids	27,38	rhodopsin	112,121	amino acids	rhodopsin	CHEBI:33709	509933(Tax:9913)	Chemical	Gene	Val170-Arg182|amod|START_ENTITY segment|nmod|Val170-Arg182 capable|nsubj|segment capable|xcomp|phosphorylated phosphorylated|dobj|END_ENTITY	A segment corresponding to amino_acids Val170-Arg182 of bovine arrestin is capable of binding to phosphorylated rhodopsin .
9130705	0	amino_acids	46,57	rhodopsin	119,128	amino acids	rhodopsin	CHEBI:33709	42367(Tax:7227)	Chemical	Gene	mutagenesis|nmod|START_ENTITY blocks|nsubj|mutagenesis blocks|dobj|synthesis synthesis|compound|END_ENTITY	Site-directed mutagenesis of highly conserved amino_acids in the first cytoplasmic loop of Drosophila Rh1 opsin blocks rhodopsin synthesis in the nascent state .
15710237	0	amino_acids	42,53	serine_racemase	14,29	amino acids	serine racemase	CHEBI:33709	27364(Tax:10090)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|activity activity|amod|END_ENTITY	Regulation of serine_racemase activity by amino_acids .
2570126	0	amino_acids	22,33	somatostatin	37,49	amino acids	somatostatin	CHEBI:33709	24797(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	Actions of excitatory amino_acids on somatostatin release from cortical neurons in primary cultures .
2896149	0	amino_acids	68,79	somatostatin	10,22	amino acids	somatostatin	CHEBI:33709	6750	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of somatostatin on skin_lesions and concentrations of plasma amino_acids in a patient with glucagonoma-syndrome .
6107270	0	amino_acids	52,63	somatostatin	14,26	amino acids	somatostatin	CHEBI:33709	24797(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY effect|nmod|release effect|nmod|END_ENTITY	The effect of somatostatin -LRB- SRIF -RRB- on the release of amino_acids from skeletal muscle .
11069988	0	amino_acids	19,30	tax	78,81	amino acids	tax	CHEBI:33709	6900	Chemical	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	The region between amino_acids 245 and 265 of the bovine_leukemia_virus _ -LRB- BLV -RRB- tax protein restricts transactivation not only via the BLV enhancer but also via other retrovirus enhancers .
2061338	0	amino_acids	54,65	thioltransferase	100,116	amino acids	thioltransferase	CHEBI:33709	397463(Tax:9823)	Chemical	Gene	Identification|nmod|START_ENTITY END_ENTITY|nsubj|Identification	Identification and characterization of the functional amino_acids at the active center of pig liver thioltransferase by site-directed mutagenesis .
9368022	0	amino_acids	54,65	thioredoxin_reductase	98,119	amino acids	thioredoxin reductase	CHEBI:33709	25824	Chemical	Gene	START_ENTITY|nmod|site site|nmod|END_ENTITY	Identification and characterization of the functional amino_acids at the active site of the large thioredoxin_reductase from Plasmodium_falciparum .
3855750	0	amino_acids	65,76	thyroglobulin	87,100	amino acids	thyroglobulin	CHEBI:33709	280706(Tax:9913)	Chemical	Gene	Presence|nmod|START_ENTITY Presence|nmod|END_ENTITY	Presence of hormonogenic and repetitive domains in the first 930 amino_acids of bovine thyroglobulin as deduced from the cDNA sequence .
9373172	0	amino_acids	63,74	thyroid_hormone_receptor_alpha	8,38	amino acids	thyroid hormone receptor alpha	CHEBI:33709	396251(Tax:9031)	Chemical	Gene	requires|dobj|START_ENTITY requires|nsubj|END_ENTITY	Chicken thyroid_hormone_receptor_alpha requires the N-terminal amino_acids for exclusive nuclear localization .
422660	0	amino_acids	14,25	tsHl	112,116	amino acids	tsHl	CHEBI:33709	6762	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of amino_acids on the temperature sensitive phenotype of the mammalian leucyl-tRNA_synthetase mutant tsHl and its revertants .
11448951	0	amino_acids	46,57	tumor_necrosis_factor	18,39	amino acids	tumor necrosis factor	CHEBI:33709	21926(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification of tumor_necrosis_factor -LRB- TNF -RRB- amino_acids crucial for binding to the murine p75 TNF receptor and construction of receptor-selective mutants .
11154106	0	amino_acids	72,83	vWF	118,121	amino acids	vWF	CHEBI:33709	7450	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Binding of von_Willebrand factor to collagen type III : role of specific amino_acids in the collagen binding domain of vWF and effects of neighboring domains .
2476129	0	amino_acids	39,50	vWF	77,80	amino acids	vWF	CHEBI:33709	7450	Chemical	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization within the 106 N-terminal amino_acids of von_Willebrand factor -LRB- vWF -RRB- of the epitope corresponding to a monoclonal antibody which inhibits vWF binding to factor VIII .
20358537	0	amino_amides	9,21	L-asparaginase	45,59	amino amides	L-asparaginase	null	80150	Chemical	Gene	Study|nmod|START_ENTITY Study|nmod|END_ENTITY	Study on amino_amides and enzyme kinetics of L-asparaginase by MCE .
9879512	0	amino_ethers	42,54	monoamine_oxidase_B	78,97	amino ethers	monoamine oxidase B	null	4129	Chemical	Gene	START_ENTITY|nmod|inactivation inactivation|nmod|END_ENTITY	Effect of the locus of the oxygen atom in amino_ethers on the inactivation of monoamine_oxidase_B .
20673718	0	amino_propanamide	87,104	renin	105,110	amino propanamide	renin	null	5972	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Addressing time-dependent CYP_3A4 inhibition observed in a novel series of substituted amino_propanamide renin inhibitors , a case study .
11463327	0	amino_sugar	17,28	C-1027	34,40	amino sugar	C-1027	CHEBI:28963	1038631(Tax:199310)	Chemical	Gene	Synthesis|nmod|START_ENTITY Synthesis|nmod|END_ENTITY	Synthesis of the amino_sugar from C-1027 .
18678449	0	aminoacid	39,48	MECP2	2,7	aminoacid	MECP2	CHEBI:33704	4204	Chemical	Gene	START_ENTITY|nsubj|mutation mutation|compound|END_ENTITY	A MECP2 mutation in a highly conserved aminoacid causing mental_retardation in a male .
25686591	0	aminoacyl-sulfamoyl_adenosines	86,116	aaRS	120,124	aminoacyl-sulfamoyl adenosines	aaRS	null	16	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	5 ' - -LRB- N-aminoacyl -RRB- - sulfonamido-5 ' - deoxyadenosine : Attempts for a stable alternative for aminoacyl-sulfamoyl_adenosines as aaRS inhibitors .
20953603	0	aminoalcohol	24,36	MAK154	84,90	aminoalcohol	MAK154	CHEBI:22478	5741109(Tax:119912)	Chemical	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Genetic analysis around aminoalcohol dehydrogenase gene of Rhodococcus_erythropolis MAK154 : a putative GntR transcription factor in transcriptional regulation .
23317517	0	aminoalcohols	73,86	syn	55,58	aminoalcohols	syn	MESH:D000605	23336	Chemical	Gene	START_ENTITY|nsubj|synthesis synthesis|nmod|END_ENTITY	Concise asymmetric synthesis of orthogonally protected syn - and anti-1 ,3 - aminoalcohols .
12372523	0	aminoalkylazetidines	50,70	ORL1	74,78	aminoalkylazetidines	ORL1	null	4987	Chemical	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	Synthesis and structure-activity relationships of aminoalkylazetidines as ORL1 receptor ligands .
6481356	0	aminoalkylphosphonic_acids	58,84	transferrin	43,54	aminoalkylphosphonic acids	transferrin	null	7018	Chemical	Gene	Kinetics|nmod|START_ENTITY Kinetics|nmod|END_ENTITY	Kinetics of the removal of ferric ion from transferrin by aminoalkylphosphonic_acids .
7178650	0	aminobenzenesulfonic_acids	24,50	glutathione_S-transferase	101,126	aminobenzenesulfonic acids	glutathione S-transferase	MESH:D013425	58962(Tax:10116)	Chemical	Gene	interaction|nmod|START_ENTITY END_ENTITY|nmod|interaction	In vitro interaction of aminobenzenesulfonic_acids and their N-acetylated derivatives with rat liver glutathione_S-transferase .
8485108	0	aminobenzolamide	25,41	carbonic_anhydrase_II	59,80	aminobenzolamide	carbonic anhydrase II	null	760	Chemical	Gene	complex|amod|START_ENTITY complex|nmod|END_ENTITY	Refined structure of the aminobenzolamide complex of human carbonic_anhydrase_II at 1.9 A and sulphonamide modelling of bovine carbonic_anhydrase_III .
1307594	0	aminocaproic_acid	7,24	MTP	49,52	aminocaproic acid	MTP	MESH:D000614	4490	Chemical	Gene	Use|nmod|START_ENTITY Use|nmod|END_ENTITY	Use of aminocaproic_acid -LRB- ACA -RRB- in extra-amniotic MTP in patients on anti-coagulant therapy .
12947763	0	aminoethyl_glycosides	14,35	Gb3	78,81	aminoethyl glycosides	Gb3	null	53947	Chemical	Gene	Synthesis|nmod|START_ENTITY Synthesis|nmod|END_ENTITY	-LSB- Synthesis of aminoethyl_glycosides of the carbohydrate chains of glycolipids Gb3 , Gb4 i Gb5 -RSB- .
19763898	0	aminoethylisothiourea	22,43	tyrosinase	56,66	aminoethylisothiourea	tyrosinase	MESH:C413842	7299	Chemical	Gene	evaluation|nmod|START_ENTITY END_ENTITY|nsubj|evaluation	Kinetic evaluation of aminoethylisothiourea on mushroom tyrosinase activity .
15017268	0	aminoflavone	39,51	CYP1A1	61,67	aminoflavone	CYP1A1	MESH:C413760	1543	Chemical	Gene	Sensitivity|acl|START_ENTITY Sensitivity|dep|role role|nmod|END_ENTITY	Sensitivity of renal_cell_carcinoma to aminoflavone : role of CYP1A1 .
16096788	0	aminoflavone	21,33	CYP1A1	0,6	aminoflavone	CYP1A1	MESH:C413760	1543	Chemical	Gene	activation|nmod|START_ENTITY activation|nummod|END_ENTITY	CYP1A1 activation of aminoflavone leads to DNA damage in human tumor cell lines .
24058584	0	aminoflavone	111,123	aryl_hydrocarbon_receptor	141,166	aminoflavone	aryl hydrocarbon receptor	MESH:C413760	196	Chemical	Gene	START_ENTITY|appos|ligand ligand|nmod|END_ENTITY	Reactivation of estrogen_receptor_a by vorinostat sensitizes mesenchymal-like triple-negative_breast_cancer to aminoflavone , a ligand of the aryl_hydrocarbon_receptor .
1339054	0	aminoglutethimide	11,28	ACTH	32,36	aminoglutethimide	ACTH	MESH:D000616	5443	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|compound|END_ENTITY	-LSB- Effect of aminoglutethimide on ACTH plasma levels in Cushing 's _ disease and Nelson_syndrome -RSB- .
6203148	0	aminoglutethimide	71,88	Estrogen_receptor	0,17	aminoglutethimide	Estrogen receptor	MESH:D000616	2099	Chemical	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	Estrogen_receptor status and the clinical response to a combination of aminoglutethimide and cortisol in advanced breast cancer .
15457124	0	aminoglutethimide	35,52	prostate-specific_antigen	75,100	aminoglutethimide	prostate-specific antigen	MESH:D000616	354	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|response response|amod|END_ENTITY	Effect of combination therapy with aminoglutethimide and hydrocortisone on prostate-specific_antigen response in metastatic prostate_cancer refractory to standard endocrine therapy .
17224412	0	aminoglycoside	27,41	ArmA	13,17	aminoglycoside	ArmA	CHEBI:47779	4246766(Tax:562)	Chemical	Gene	START_ENTITY|nsubj|Emergence Emergence|nmod|END_ENTITY	Emergence of ArmA and RmtB aminoglycoside resistance 16S rRNA methylases in Belgium .
8655598	0	aminoglycoside	102,116	Basic_fibroblast_growth_factor	0,30	aminoglycoside	Basic fibroblast growth factor	CHEBI:47779	54250(Tax:10116)	Chemical	Gene	injury|amod|START_ENTITY protects|nmod|injury protects|nsubj|END_ENTITY	Basic_fibroblast_growth_factor -LRB- FGF-2 -RRB- protects rat cochlear hair cells in organotypical culture from aminoglycoside injury .
25941215	0	aminoglycoside	14,28	acetyltransferase	29,46	aminoglycoside	acetyltransferase	D000617	20468107	Chemical	Gene	Inhibition|nmod|START_ENTITY END_ENTITY|nsubj|Inhibition	Inhibition of aminoglycoside acetyltransferase resistance enzymes by metal salts .
18281904	0	aminoglycoside	19,33	inducible_nitric_oxide_synthase	60,91	aminoglycoside	inducible nitric oxide synthase	CHEBI:47779	100135576(Tax:10141)	Chemical	Gene	START_ENTITY|advcl|inhibiting inhibiting|dobj|expression expression|amod|END_ENTITY	Taurine attenuates aminoglycoside ototoxicity by inhibiting inducible_nitric_oxide_synthase expression in the cochlea .
21127443	0	aminoglycosides	65,80	Insulin-like_growth_factor_1	0,28	aminoglycosides	Insulin-like growth factor 1	MESH:D000617	16000(Tax:10090)	Chemical	Gene	protects|nmod|START_ENTITY protects|nsubj|END_ENTITY	Insulin-like_growth_factor_1 protects vestibular hair cells from aminoglycosides .
1889877	0	aminoglycosides	49,64	SCE-2787	22,30	aminoglycosides	SCE-2787	MESH:D000617	5805487(Tax:448385)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Combination effect of SCE-2787 and cefepime with aminoglycosides on nosocomial gram-negative bacteria .
28293	0	aminoglycosides	17,32	albumin	48,55	aminoglycosides	albumin	MESH:D000617	213	Chemical	Gene	binding|nmod|START_ENTITY END_ENTITY|nsubj|binding	Ionic binding of aminoglycosides to human serum albumin in the absence of divalent cations .
16361952	0	aminoglycosides	88,103	alpha7_neuronal_nicotinic_acetylcholine_receptor	36,84	aminoglycosides	alpha7 neuronal nicotinic acetylcholine receptor	MESH:D000617	1139	Chemical	Gene	sensitivity|nmod|START_ENTITY sensitivity|nmod|END_ENTITY	Unexpected sensitivity of the human alpha7_neuronal_nicotinic_acetylcholine_receptor to aminoglycosides .
11457726	0	aminoglycosides	37,52	megalin	8,15	aminoglycosides	megalin	MESH:D000617	29216(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of megalin in renal handling of aminoglycosides .
9585574	0	aminoglycosides	43,58	phospholipase_A2	14,30	aminoglycosides	phospholipase A2	MESH:D000617	151056	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Modulation of phospholipase_A2 activity by aminoglycosides and daptomycin : a Fourier transform infrared spectroscopic study .
18790185	0	aminoguanidine	105,119	Inducible_nitric_oxide_synthase	0,31	aminoguanidine	Inducible nitric oxide synthase	MESH:C004479	4843	Chemical	Gene	expressions|nmod|START_ENTITY expressions|amod|END_ENTITY	Inducible_nitric_oxide_synthase expressions in different lung_injury models and the protective effect of aminoguanidine .
9848857	0	aminoguanidine	97,111	Inducible_nitric_oxide_synthase	0,31	aminoguanidine	Inducible nitric oxide synthase	MESH:C004479	24599(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY expression|nmod|treatment expression|amod|END_ENTITY	Inducible_nitric_oxide_synthase expression after traumatic brain_injury and neuroprotection with aminoguanidine treatment in rats .
8461048	0	aminoguanidine	55,69	S-adenosylmethionine_decarboxylase	17,51	aminoguanidine	S-adenosylmethionine decarboxylase	MESH:C004479	11702(Tax:10090)	Chemical	Gene	Stabilization|nmod|START_ENTITY Stabilization|nmod|END_ENTITY	Stabilization of S-adenosylmethionine_decarboxylase by aminoguanidine .
11330554	0	aminoguanidine	50,64	TNFalpha	68,76	aminoguanidine	TNFalpha	MESH:C004479	24835(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	The effect of advanced glycation end-products and aminoguanidine on TNFalpha production by rat peritoneal macrophages .
22553657	0	aminoguanidine	10,24	caspase-3	28,37	aminoguanidine	caspase-3	MESH:C004479	25402(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of aminoguanidine on caspase-3 expression in rat retina after ischemia-reperfusion_injury .
12175893	8	aminoguanidine	1340,1354	iNOS	1258,1262	aminoguanidine	iNOS	MESH:C004479	18126(Tax:10090)	Chemical	Gene	administration|nmod|START_ENTITY affected|nmod|administration affected|nsubjpass|activity activity|amod|END_ENTITY	The iNOS activity and NO level in the core were not affected by the administration of aminoguanidine .
16201316	0	aminoguanidine	10,24	iNOS	77,81	aminoguanidine	iNOS	MESH:C004479	18126(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activity activity|appos|END_ENTITY	Effect of aminoguanidine and albendazole on inducible nitric_oxide synthase -LRB- iNOS -RRB- activity in T. _ spiralis-infected mice muscles .
16978515	0	aminoguanidine	37,51	iNOS	22,26	aminoguanidine	iNOS	MESH:C004479	24599(Tax:10116)	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|Effects Effects|nmod|END_ENTITY	-LSB- Effects of selective iNOS inhibitor aminoguanidine on waveform of blood pressure in rat heat_stroke -RSB- .
18222473	0	aminoguanidine	186,200	iNOS	46,50	aminoguanidine	iNOS	MESH:C004479	24599(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY injury|dep|role peroxidation|nmod|injury peroxidation|dep|END_ENTITY	Liver tissue inducible nitric_oxide synthase -LRB- iNOS -RRB- expression and lipid peroxidation in experimental hepatic_ischemia reperfusion injury stimulated with lipopolysaccharide : the role of aminoguanidine .
19301028	0	aminoguanidine	64,78	iNOS	49,53	aminoguanidine	iNOS	MESH:C004479	18126(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Suppression_of_retinal_neovascularization Suppression_of_retinal_neovascularization|nmod|inhibitor inhibitor|amod|END_ENTITY	Suppression_of_retinal_neovascularization by the iNOS inhibitor aminoguanidine in mice of oxygen-induced retinopathy .
10477114	0	aminoguanidine	113,127	inducible_nitric_oxide_synthase	14,45	aminoguanidine	inducible nitric oxide synthase	MESH:C004479	24599(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY Expression|dep|effect Expression|nmod|immunoreactivity immunoreactivity|amod|END_ENTITY	Expression of inducible_nitric_oxide_synthase immunoreactivity in rat brain following chronic hypoxia : effect of aminoguanidine .
12359315	0	aminoguanidine	11,25	inducible_nitric_oxide_synthase	97,128	aminoguanidine	inducible nitric oxide synthase	MESH:C004479	18126(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|dep|comparison comparison|nmod|mice mice|nmod|gene gene|amod|END_ENTITY	Effects of aminoguanidine on cerebral_ischemia in mice : comparison between mice with and without inducible_nitric_oxide_synthase gene .
8874192	0	aminoguanidine	86,100	inducible_nitric_oxide_synthase	127,158	aminoguanidine	inducible nitric oxide synthase	MESH:C004479	18126(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Recipient humoral immunity against leukoreduced allogeneic platelets is suppressed by aminoguanidine , a selective inhibitor of inducible_nitric_oxide_synthase .
9538001	0	aminoguanidine	61,75	inducible_nitric_oxide_synthase	13,44	aminoguanidine	inducible nitric oxide synthase	MESH:C004479	4843	Chemical	Gene	inactivation|nmod|START_ENTITY inactivation|amod|END_ENTITY	Mechanism of inducible_nitric_oxide_synthase inactivation by aminoguanidine and L-N6 - -LRB- 1-iminoethyl -RRB- lysine .
17333105	7	aminoguanidine	1556,1570	rats	1619,1623	aminoguanidine	CTGF	MESH:C004479	64032(Tax:10116)	Chemical	Gene	Treatment|nmod|START_ENTITY inhibited|nsubj|Treatment inhibited|nmod|END_ENTITY	Treatment with aminoguanidine inhibited Cyr61 and Ctgf expression in diabetic rats , with reductions of 31 and 36 % , respectively , compared with untreated animals .
11245022	0	aminoguanidine	90,104	receptor_for_advanced_glycosylation_end_products	19,67	aminoguanidine	receptor for advanced glycosylation end products	MESH:C004479	81722(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Gene expression of receptor_for_advanced_glycosylation_end_products and its modulation by aminoguanidine in diabetic kidney tissue .
8898921	0	aminohexyl	63,73	diamine_oxidase	27,42	aminohexyl	diamine oxidase	null	26	Chemical	Gene	chromatography|amod|START_ENTITY END_ENTITY|nmod|chromatography	Lactoferrin : similarity to diamine_oxidase and purification by aminohexyl affinity chromatography .
23017051	0	aminoimidazoles	4,19	BACE-1	36,42	aminoimidazoles	BACE-1	CHEBI:22512	100135485(Tax:10141)	Chemical	Gene	START_ENTITY|advcl|showing showing|nsubj|inhibitors inhibitors|appos|END_ENTITY	New aminoimidazoles as b-secretase -LRB- BACE-1 -RRB- inhibitors showing amyloid-b -LRB- Ab -RRB- lowering in brain .
7311816	0	aminolevulinic_acid	37,56	ALAD	70,74	aminolevulinic acid	ALAD	MESH:D000622	210	Chemical	Gene	START_ENTITY|dobj|activity activity|appos|END_ENTITY	-LSB- Lead concentration in the blood and aminolevulinic_acid dehydratase -LRB- ALAD -RRB- activity in the erythrocytes depending on sex , age , tobacco smoking and alcohol drinking in the group of persons exposed to industrial dust -RSB- .
9871520	0	aminomethylene_ketone	15,36	interleukin-1_beta-converting_enzyme	51,87	aminomethylene ketone	interleukin-1 beta-converting enzyme	null	834	Chemical	Gene	START_ENTITY|dobj|inhibitors inhibitors|nmod|END_ENTITY	Peptidomimetic aminomethylene_ketone inhibitors of interleukin-1_beta-converting_enzyme -LRB- ICE -RRB- .
16302794	0	aminonitriles	57,70	cathepsin_K	124,135	aminonitriles	cathepsin K	null	29175(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Design and synthesis of tri-ring P3 benzamide-containing aminonitriles as potent , selective , orally effective inhibitors of cathepsin_K .
804698	0	aminophylline	52,65	Parathyroid_hormone	0,19	aminophylline	Parathyroid hormone	MESH:D000628	24694(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY secretion|dep|effect secretion|amod|END_ENTITY	Parathyroid_hormone secretion in the rat : effect of aminophylline -LRB- 38536 -RRB- .
1963648	0	aminophylline	56,69	insulin	16,23	aminophylline	insulin	MESH:D000628	3630	Chemical	Gene	infusion|amod|START_ENTITY effects|nmod|infusion secretion|dep|effects secretion|compound|END_ENTITY	Glucose-induced insulin secretion in uremia : effects of aminophylline infusion and glucose loads .
2904278	0	aminopterin	124,135	folylpoly-gamma-glutamate_synthetase	35,71	aminopterin	folylpoly-gamma-glutamate synthetase	MESH:D000630	2356	Chemical	Gene	specificity|nmod|START_ENTITY specificity|nmod|END_ENTITY	Substrate specificity of mammalian folylpoly-gamma-glutamate_synthetase for 5,8-dideazafolates and 5,8-dideaza analogues of aminopterin .
26403928	0	aminopyrazine	48,61	mitogen-activated_protein_kinase-activated_protein_kinase_2	91,150	aminopyrazine	mitogen-activated protein kinase-activated protein kinase 2	null	9261	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|inhibitors inhibitors|nmod|END_ENTITY	Design , synthesis , and biological evaluation of aminopyrazine derivatives as inhibitors of mitogen-activated_protein_kinase-activated_protein_kinase_2 -LRB- MK-2 -RRB- .
19261605	0	aminopyrazole	84,97	c-Jun_N-terminal_kinase_3	113,138	aminopyrazole	c-Jun N-terminal kinase 3	null	5602	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Structure-activity relationships and X-ray structures describing the selectivity of aminopyrazole inhibitors for c-Jun_N-terminal_kinase_3 -LRB- JNK3 -RRB- over p38 .
17315857	0	aminopyridines	79,93	beta-secretase	111,125	aminopyridines	beta-secretase	MESH:D000631	23621	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Application of fragment screening by X-ray crystallography to the discovery of aminopyridines as inhibitors of beta-secretase .
20006500	0	aminopyridines	105,119	hERG	86,90	aminopyridines	hERG	MESH:D000631	2078	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Tetrasubstituted_pyridines as potent and selective AKT inhibitors : Reduced CYP450 and hERG inhibition of aminopyridines .
1656774	0	aminopyrine	41,52	Gastrin	0,7	aminopyrine	Gastrin	MESH:D000632	25320(Tax:10116)	Chemical	Gene	accumulation|compound|START_ENTITY potentiates|dobj|accumulation potentiates|nsubj|END_ENTITY	Gastrin potentiates histamine-stimulated aminopyrine accumulation in isolated rat parietal cells .
6097363	0	aminopyrine	80,91	catalase	123,131	aminopyrine	catalase	MESH:D000632	847	Chemical	Gene	START_ENTITY|nmod|presence presence|nmod|END_ENTITY	Electron spin resonance studies on the reaction of peroxyphenylacetic_acid with aminopyrine in the presence and absence of catalase .
19200624	0	aminopyrrolidine	16,32	factor_Xa	33,42	aminopyrrolidine	factor Xa	CHEBI:46769	2159	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Design of novel aminopyrrolidine factor_Xa inhibitors from a screening hit .
16970394	0	aminoquinazolines	13,30	Lck	76,79	aminoquinazolines	Lck	null	16818(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Discovery of aminoquinazolines as potent , orally bioavailable inhibitors of Lck : synthesis , SAR , and in vivo anti-inflammatory activity .
15854172	0	aminosalicylates	11,27	thiopurine_S-methyltransferase	31,61	aminosalicylates	thiopurine S-methyltransferase	null	7172	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effects of aminosalicylates on thiopurine_S-methyltransferase activity : an ex vivo study in patients with inflammatory_bowel_disease .
12190313	0	aminothiazole	13,26	cyclin-dependent_kinase_2	41,66	aminothiazole	cyclin-dependent kinase 2	null	1017	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Discovery of aminothiazole inhibitors of cyclin-dependent_kinase_2 : synthesis , X-ray crystallographic analysis , and biological activities .
2491792	0	aminothiols	48,59	L-threonine_dehydratase	21,44	aminothiols	L-threonine dehydratase	null	25044(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Double inhibition of L-threonine_dehydratase by aminothiols .
1154374	0	aminotriazole	52,65	catalase	12,20	aminotriazole	catalase	MESH:D000640	12359(Tax:10090)	Chemical	Gene	Recovery|nmod|START_ENTITY Recovery|nmod|activity activity|amod|END_ENTITY	Recovery of catalase activity after inhibition with aminotriazole in acatalasemia mice .
14681974	0	aminotriazole	11,24	catalase	44,52	aminotriazole	catalase	MESH:D000640	847	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	-LSB- Effect of aminotriazole on the activity of catalase and glucose-6-phosphate_dehydrogenase in tissues of two frog species -- Rana ridibunda and Rana esculenta -RSB- .
1995347	0	aminotriazole	5,18	catalase	37,45	aminotriazole	catalase	MESH:D000640	847	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|import import|nmod|END_ENTITY	Does aminotriazole inhibit import of catalase into peroxisomes by retarding unfolding ?
642030	0	aminotriazole	38,51	catalase	79,87	aminotriazole	catalase	MESH:D000640	12359(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|mice mice|compound|END_ENTITY	Carcinogenic and antitumor effects of aminotriazole on acatalasemic and normal catalase mice .
666320	0	aminotriazole	94,107	catalase	58,66	aminotriazole	catalase	MESH:D000640	12359(Tax:10090)	Chemical	Gene	ester|amod|START_ENTITY effects|nmod|ester effects|nmod|synthesis synthesis|nmod|forms forms|nmod|END_ENTITY	On the synthesis and degradation of the multiple forms of catalase in mouse liver : effects of aminotriazole and p-chlorophenoxyisobutric acid ethyl ester .
7546330	0	aminotriazole	11,24	catalase	73,81	aminotriazole	catalase	MESH:D000640	24248(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of aminotriazole on ethanol , water , and food intake and on brain catalase in UChA and UChB rats .
7980465	0	aminotriazole	100,113	catalase	12,20	aminotriazole	catalase	MESH:D000640	847	Chemical	Gene	presence|nmod|START_ENTITY inactivation|nmod|presence inactivation|compound|END_ENTITY	Erythrocyte catalase inactivation -LRB- H2O2 production -RRB- by ascorbic_acid and glucose in the presence of aminotriazole : role of transition_metals and relevance to diabetes .
18457571	0	aminotriazole	26,39	glucose-6-phosphate_dehydrogenase	72,105	aminotriazole	glucose-6-phosphate dehydrogenase	MESH:D000640	855480(Tax:4932)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activity activity|amod|END_ENTITY	Inhibition of catalase by aminotriazole in vivo results in reduction of glucose-6-phosphate_dehydrogenase activity in Saccharomyces_cerevisiae cells .
12410055	6	amiodarone	903,913	CYP2D6	884,890	amiodarone	CYP3A4	MESH:D000638	1576	Chemical	Gene	inhibitors|dep|START_ENTITY inhibitors|nummod|END_ENTITY	Possible interactions with CYP2D6 inhibitors -LRB- amiodarone , fluoxetine or ritonavir -RRB- and CYP3A4 inhibitors -LRB- indinavir and ritonavir -RRB- can increase its serum concentrations and produce significant adverse effects .
3986060	0	amiodarone	7,17	Fab	39,42	amiodarone	Fab	MESH:D000638	2187	Chemical	Gene	antibodies|amod|START_ENTITY antibodies|amod|END_ENTITY	Use of amiodarone and digoxin specific Fab antibodies in digoxin overdosage .
1841729	0	amiodarone	11,21	T3	31,33	amiodarone	T3	MESH:D000638	24754(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of amiodarone on serum T3 and T4 concentrations in hyperthyroid patients treated with propylthiouracil .
7083508	0	amiodarone	63,73	T3	46,48	amiodarone	T3	MESH:D000638	24754(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY levels|nmod|treatment levels|compound|END_ENTITY	Pharmacokinetic significance of serum reverse T3 levels during amiodarone treatment : a potential method for monitoring chronic drug therapy .
19777211	0	amiodarone	117,127	TASK-1	26,32	amiodarone	TASK-1	MESH:D000638	3777	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	The human cardiac K2P3 .1 -LRB- TASK-1 -RRB- potassium leak channel is a molecular target for the class III antiarrhythmic drug amiodarone .
23042730	0	amiodarone	60,70	Tumor_necrosis_factor-alpha	0,27	amiodarone	Tumor necrosis factor-alpha	MESH:D000638	21926(Tax:10090)	Chemical	Gene	cytotoxicity|nmod|START_ENTITY potentiates|dep|cytotoxicity potentiates|amod|END_ENTITY	Tumor_necrosis_factor-alpha potentiates the cytotoxicity of amiodarone in Hepa1c1c7 cells : roles of caspase activation and oxidative stress .
15317834	0	amiodarone	58,68	thrombin	102,110	amiodarone	thrombin	MESH:D000638	2147	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	A pharmacokinetic study of the combined administration of amiodarone and ximelagatran , an oral direct thrombin inhibitor .
10072229	0	amiodarone	11,21	tumor_necrosis_factor-alpha	25,52	amiodarone	tumor necrosis factor-alpha	MESH:D000638	7124	Chemical	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	Effects of amiodarone on tumor_necrosis_factor-alpha levels in congestive_heart_failure secondary to ischemic or idiopathic_dilated_cardiomyopathy .
16252067	0	amisulpride	101,112	P-glycoprotein	140,154	amisulpride	P-glycoprotein	MESH:C012052	287115(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Cyclosporine_A -LRB- CsA -RRB- affects the pharmacodynamics and pharmacokinetics of the atypical antipsychotic amisulpride probably via inhibition of P-glycoprotein -LRB- P-gp -RRB- .
8935811	0	amisulpride	61,72	dopamine_D2_receptor	27,47	amisulpride	dopamine D2 receptor	MESH:C012052	1813	Chemical	Gene	occupancy|nmod|START_ENTITY occupancy|amod|END_ENTITY	In vivo characteristics of dopamine_D2_receptor occupancy by amisulpride in schizophrenia .
18359183	0	amitriptyline	80,93	CYP2D6	104,110	amitriptyline	CYP2D6	MESH:D000639	1565	Chemical	Gene	START_ENTITY|nmod|metabolizer metabolizer|compound|END_ENTITY	Life-threatening dextromethorphan intoxication associated with interaction with amitriptyline in a poor CYP2D6 metabolizer : a single case re-exposure study .
11812713	0	amitriptyline	11,24	Fos	53,56	amitriptyline	Fos	MESH:D000639	314322(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Peripheral amitriptyline suppresses formalin-induced Fos expression in the rat spinal cord .
23337936	0	amitriptyline	37,50	brain-derived_neurotrophic_factor	89,122	amitriptyline	brain-derived neurotrophic factor	MESH:D000639	24225(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of chronic administration of amitriptyline , gabapentin and minocycline on spinal brain-derived_neurotrophic_factor expression and neuropathic_pain behavior in a rat chronic_constriction_injury model .
10081979	0	amitriptyline	8,21	serotonin_transporter	47,68	amitriptyline	serotonin transporter	MESH:D000639	25553(Tax:10116)	Chemical	Gene	increases|compound|START_ENTITY END_ENTITY|nsubj|increases	Chronic amitriptyline administration increases serotonin_transporter binding sites in the hippocampus of aged rats .
3929293	0	amitriptyline	10,23	thyrotropin-releasing_hormone	55,84	amitriptyline	thyrotropin-releasing hormone	MESH:D000639	7200	Chemical	Gene	Effect|nmod|START_ENTITY Effect|acl|END_ENTITY	Effect of amitriptyline on the thyrotropin response to thyrotropin-releasing_hormone in endogenous_depression .
7577405	0	amitriptyline	16,29	vasopressin	66,77	amitriptyline	vasopressin	MESH:D000639	551	Chemical	Gene	comparison|nmod|START_ENTITY comparison|nmod|END_ENTITY	A comparison of amitriptyline , vasopressin and amitriptyline with vasopressin in nocturnal enuresis .
23863802	0	amlodipine	21,31	CYP3A5	0,6	amlodipine	CYP3A5	MESH:D017311	1577	Chemical	Gene	polymorphism|appos|START_ENTITY polymorphism|compound|END_ENTITY	CYP3A5 polymorphism , amlodipine and hypertension .
25390761	0	amlodipine	115,125	Endocan	0,7	amlodipine	Endocan	MESH:D017311	11082	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|dep|effects	Endocan , a novel marker of endothelial_dysfunction in patients with essential hypertension : comparative effects of amlodipine and valsartan .
21337027	0	amlodipine	11,21	Smad2	39,44	amlodipine	Smad2	MESH:D017311	29357(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of amlodipine on TGF-b-induced Smad2 , 4 expressions in adriamycin toxicity of rat mesangial cells .
17085863	0	amlodipine	13,23	TNF-alpha	97,106	amlodipine	TNF-alpha	MESH:D017311	24835(Tax:10116)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|dep|concentrations concentrations|nmod|IL-6 IL-6|compound|END_ENTITY	Influence of amlodipine and atenolol on lipopolysaccharide -LRB- LPS -RRB- - induced serum concentrations of TNF-alpha , IL-1 , IL-6 in spontaneously hypertensive rats -LRB- SHR -RRB- .
8733040	0	amlodipine	100,110	erythropoietin	46,60	amlodipine	erythropoietin	MESH:D017311	2056	Chemical	Gene	treatment|nmod|START_ENTITY END_ENTITY|nmod|treatment	Decreased_blood_viscosity and serum levels of erythropoietin after anti-hypertensive treatment with amlodipine or metoprolol : results of a cross-over study .
18981627	0	amlodipine	32,42	insulin	46,53	amlodipine	insulin	MESH:D017311	3630	Chemical	Gene	START_ENTITY|nmod|sensitivity sensitivity|compound|END_ENTITY	Effect of valsartan addition to amlodipine on insulin sensitivity in overweight-obese hypertensive patients .
7885275	0	amlodipine	98,108	insulin	15,22	amlodipine	insulin	MESH:D017311	3630	Chemical	Gene	START_ENTITY|nsubj|Improvement Improvement|nmod|sensitivity sensitivity|compound|END_ENTITY	Improvement of insulin sensitivity for glucose metabolism with the long-acting Ca-channel blocker amlodipine in essential hypertensive subjects .
8359183	0	amlodipine	28,38	insulin	42,49	amlodipine	insulin	MESH:D017311	3630	Chemical	Gene	Lack|nmod|START_ENTITY Lack|nmod|sensitivity sensitivity|compound|END_ENTITY	Lack of effect of long-term amlodipine on insulin sensitivity and plasma insulin in obese patients with essential hypertension .
9269636	0	amlodipine	27,37	insulin	50,57	amlodipine	insulin	MESH:D017311	3630	Chemical	Gene	blocker|appos|START_ENTITY attenuates|nsubj|blocker attenuates|dobj|antinatriuresis antinatriuresis|compound|END_ENTITY	A calcium-channel blocker , amlodipine , attenuates insulin antinatriuresis but does not modulate insulin-mediated attenuation of cardiovascular reactivity in healthy man .
17073832	0	amlodipine	144,154	renin	66,71	amlodipine	renin	MESH:D017311	5972	Chemical	Gene	Lack|nmod|START_ENTITY Lack|appos|inhibitor inhibitor|compound|END_ENTITY	Lack of pharmacokinetic interactions of aliskiren , a novel direct renin inhibitor for the treatment of hypertension , with the antihypertensives amlodipine , valsartan , hydrochlorothiazide -LRB- HCTZ -RRB- and ramipril in healthy volunteers .
17917501	0	amlodipine	119,129	renin	45,50	amlodipine	renin	MESH:D017311	5972	Chemical	Gene	responding|xcomp|START_ENTITY aliskiren|advcl|responding aliskiren|nsubj|efficacy efficacy|nmod|inhibitor inhibitor|compound|END_ENTITY	Antihypertensive efficacy of the oral direct renin inhibitor aliskiren as add-on therapy in patients not responding to amlodipine monotherapy .
17954368	0	amlodipine	97,107	renin	21,26	amlodipine	renin	MESH:D017311	5972	Chemical	Gene	responses|nmod|START_ENTITY affect|dobj|responses affect|nmod|system system|compound|END_ENTITY	Does blockade of the renin angiotensin system affect sympathetic and blood pressure responses to amlodipine in young hypertensive patients ?
8904650	0	amlodipine	10,20	renin	24,29	amlodipine	renin	MESH:D017311	24715(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|amod|END_ENTITY	Effect of amlodipine on renin secretion and renin gene expression in rats .
9508672	0	amlodipine	34,44	renin	55,60	amlodipine	renin	MESH:D017311	5972	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	-LSB- Effect of 12-week treatment with amlodipine on plasma renin activity and adrenal cortex function in patients with essential_hypertension -RSB- .
18992343	0	ammonia	36,43	CNTF	0,4	ammonia	CNTF	MESH:D000641	1270	Chemical	Gene	toxicity|compound|START_ENTITY protects|nmod|toxicity protects|nsubj|END_ENTITY	CNTF protects oligodendrocytes from ammonia toxicity : intracellular signaling pathways involved .
18840656	0	ammonia	45,52	CO2	15,18	ammonia	CO2	MESH:D000641	717	Chemical	Gene	excretion|compound|START_ENTITY effects|nmod|excretion effects|nmod|END_ENTITY	The effects of CO2 and external buffering on ammonia excretion and Rhesus glycoprotein mRNA expression in rainbow_trout .
15644514	15	ammonia	2174,2181	GLU	2194,2197	ammonia	STA	MESH:D000641	102657351	Chemical	Gene	production|compound|START_ENTITY production|appos|END_ENTITY	This experiment demonstrated that provision of readily fermentable energy can decrease ammonia concentrations in the rumen through decreased ammonia production -LRB- GLU -RRB- , or through enhanced uptake of ammonia for microbial protein synthesis -LRB- STA -RRB- .
23904565	0	ammonia	40,47	RHCG	76,80	ammonia	RHCG	MESH:D000641	51458	Chemical	Gene	members|dep|START_ENTITY Expression|nmod|members END_ENTITY|nsubj|Expression	Expression of the rhesus glycoproteins , ammonia transporter family members , RHCG and RHBG in male reproductive organs .
12595489	0	ammonia	28,35	RhBG	0,4	ammonia	RhBG	MESH:D000641	310625(Tax:10116)	Chemical	Gene	transporters|compound|START_ENTITY END_ENTITY|appos|transporters	RhBG and RhCG , the putative ammonia transporters , are expressed in the same cells in the distal nephron .
16131648	0	ammonia	20,27	RhBG	69,73	ammonia	RhBG	MESH:D000641	58176(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY Characterization|nmod|transport glycoproteins|nsubj|Characterization glycoproteins|dobj|END_ENTITY	Characterization of ammonia transport by the kidney Rh glycoproteins RhBG and RhCG .
19357182	0	ammonia	27,34	RhCG	0,4	ammonia	RhCG	MESH:D000641	51458	Chemical	Gene	transporter|compound|START_ENTITY transporter|nsubj|END_ENTITY	RhCG is the major putative ammonia transporter expressed in the human kidney , and RhBG is not expressed at detectable levels .
16144966	0	ammonia	24,31	Rhbg	46,50	ammonia	Rhbg	MESH:D000641	310625(Tax:10116)	Chemical	Gene	transporters|compound|START_ENTITY transporters|appos|END_ENTITY	Renal expression of the ammonia transporters , Rhbg and Rhcg , in response to chronic metabolic_acidosis .
18776723	0	ammonia	14,21	Rhbg	36,40	ammonia	Rhbg	MESH:D000641	310625(Tax:10116)	Chemical	Gene	transporters|compound|START_ENTITY transporters|appos|END_ENTITY	Expression of ammonia transporters , Rhbg and Rhcg , in chronic cyclosporine nephropathy in rats .
26471760	0	ammonia	14,21	Rhbg	35,39	ammonia	Rhbg	MESH:D000641	58176(Tax:10090)	Chemical	Gene	Expression|nmod|START_ENTITY transporters|nsubj|Expression transporters|xcomp|END_ENTITY	Expression of ammonia transporters Rhbg and Rhcg in mouse skeletal muscle and the effect of 6-week training on these proteins .
16434569	0	ammonia	43,50	Rhcg	64,68	ammonia	Rhcg	MESH:D000641	293048(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Changes in subcellular distribution of the ammonia transporter , Rhcg , in response to chronic metabolic_acidosis .
23281477	0	ammonia	128,135	Rhcg	46,50	ammonia	Rhcg	MESH:D000641	56315(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY critical|nmod|transport predisposes|parataxis|critical predisposes|nsubj|Haploinsufficiency Haploinsufficiency|nmod|END_ENTITY	Haploinsufficiency of the ammonia transporter Rhcg predisposes to chronic_acidosis : Rhcg is critical for apical and basolateral ammonia transport in the mouse collecting_duct .
23281477	0	ammonia	128,135	Rhcg	84,88	ammonia	Rhcg	MESH:D000641	56315(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY critical|nmod|transport critical|nsubj|END_ENTITY	Haploinsufficiency of the ammonia transporter Rhcg predisposes to chronic_acidosis : Rhcg is critical for apical and basolateral ammonia transport in the mouse collecting_duct .
23281477	0	ammonia	26,33	Rhcg	84,88	ammonia	Rhcg	MESH:D000641	56315(Tax:10090)	Chemical	Gene	Rhcg|compound|START_ENTITY Haploinsufficiency|nmod|Rhcg predisposes|nsubj|Haploinsufficiency predisposes|parataxis|critical critical|nsubj|END_ENTITY	Haploinsufficiency of the ammonia transporter Rhcg predisposes to chronic_acidosis : Rhcg is critical for apical and basolateral ammonia transport in the mouse collecting_duct .
24652796	0	ammonia	22,29	Rhcg	42,46	ammonia	Rhcg	MESH:D000641	56315(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY transporter|nsubj|role transporter|dobj|END_ENTITY	The role of the renal ammonia transporter Rhcg in metabolic responses to dietary protein .
11832428	0	ammonia	9,16	angiotensin_II	84,98	ammonia	angiotensin II	MESH:D000641	11606(Tax:10090)	Chemical	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Enhanced ammonia secretion by proximal tubules from mice receiving NH -LRB- 4 -RRB- Cl : role of angiotensin_II .
17189259	0	ammonia	19,26	aquaporin-8	40,51	ammonia	aquaporin-8	MESH:D000641	343	Chemical	Gene	transport|compound|START_ENTITY transport|nmod|END_ENTITY	Fast and selective ammonia transport by aquaporin-8 .
1688084	0	ammonia	29,36	arylsulfatase-A	108,123	ammonia	arylsulfatase-A	MESH:D000641	315222(Tax:10116)	Chemical	Gene	generation|nmod|START_ENTITY generation|nmod|END_ENTITY	Intralysosomal generation of ammonia from urea by endocytosed urease results in secretion of free lysosomal arylsulfatase-A and increased activity of membrane-bound beta-glucosidase in cultured brain cells .
17214191	0	ammonia	35,42	catalase	70,78	ammonia	catalase	MESH:D000641	847	Chemical	Gene	START_ENTITY|nmod|activities activities|nmod|END_ENTITY	Effect of occupational exposure to ammonia on enzymatic activities of catalase and mono amine oxidase .
17442060	0	ammonia	10,17	ciliary_neurotrophic_factor	21,48	ammonia	ciliary neurotrophic factor	MESH:D000641	25707(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|mRNA mRNA|compound|END_ENTITY	Effect of ammonia on ciliary_neurotrophic_factor mRNA and protein expression and its upstream signalling pathway in cultured rat astroglial cells : possible implication of c-fos , Sp1 and p38MAPK .
1348230	0	ammonia	14,21	gamma-glutamyl_transpeptidase	38,67	ammonia	gamma-glutamyl transpeptidase	MESH:D000641	116568(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of ammonia and pH on brain gamma-glutamyl_transpeptidase in young rats .
10403509	0	ammonia	23,30	gastrin	34,41	ammonia	gastrin	MESH:D000641	25320(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of intragastric ammonia on gastrin - , somatostatin-and somatostatin receptor subtype 2 positive-cells in rat antral mucosa .
8608890	0	ammonia	93,100	gastrin	54,61	ammonia	gastrin	MESH:D000641	25320(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|amod|END_ENTITY	Rats with gastritis have increased sensitivity to the gastrin stimulatory effects of luminal ammonia .
15050973	0	ammonia	105,112	glutamate_dehydrogenase	78,101	ammonia	glutamate dehydrogenase	MESH:D000641	2746	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	Hyperinsulinism/hyperammonemia syndrome : insights into the regulatory role of glutamate_dehydrogenase in ammonia metabolism .
22038055	0	ammonia	49,56	glutamate_dehydrogenase	12,35	ammonia	glutamate dehydrogenase	MESH:D000641	2746	Chemical	Gene	metabolism|compound|START_ENTITY role|nmod|metabolism role|nmod|END_ENTITY	The role of glutamate_dehydrogenase in mammalian ammonia metabolism .
2888750	0	ammonia	35,42	glutamate_dehydrogenase	8,31	ammonia	glutamate dehydrogenase	MESH:D000641	2746	Chemical	Gene	assimilation|compound|START_ENTITY Role|nmod|assimilation Role|nmod|END_ENTITY	Role of glutamate_dehydrogenase in ammonia assimilation in nitrogen-fixing Bacillus macerans .
10812209	0	ammonia	11,18	glutamate_transporter	22,43	ammonia	glutamate transporter	MESH:D000641	29483(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|protein protein|amod|END_ENTITY	Effects of ammonia on glutamate_transporter -LRB- GLAST -RRB- protein and mRNA in cultured rat cortical astrocytes .
10713115	0	ammonia	73,80	glutamine_phosphoribosylpyrophosphate_amidotransferase	18,72	ammonia	glutamine phosphoribosylpyrophosphate amidotransferase	MESH:D000641	5471	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Dual role for the glutamine_phosphoribosylpyrophosphate_amidotransferase ammonia channel .
25040426	0	ammonia	62,69	thrombospondin-1	21,37	ammonia	thrombospondin-1	MESH:D000641	7057	Chemical	Gene	treatment|compound|START_ENTITY secretion|nmod|treatment secretion|amod|END_ENTITY	Decreased astrocytic thrombospondin-1 secretion after chronic ammonia treatment reduces the level of synaptic proteins : in vitro and in vivo studies .
14735783	0	ammonia_stimulate	13,30	monoamine_oxidase_A	31,50	ammonia stimulate	monoamine oxidase A	null	29253(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	-LSB- Calcium and ammonia_stimulate monoamine_oxidase_A activity in brain mitochondria -RSB- .
24106674	0	ammoniacum	19,29	acetylcholinesterase	35,55	ammoniacum	acetylcholinesterase	null	43	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Compounds from gum ammoniacum with acetylcholinesterase inhibitory activity .
14671018	0	ammonium	41,49	ASN2	15,19	ammonium	ASN2	MESH:D000644	836625(Tax:3702)	Chemical	Gene	metabolism|compound|START_ENTITY expression|nmod|metabolism expression|compound|END_ENTITY	Correlation of ASN2 gene expression with ammonium metabolism in Arabidopsis .
10675553	0	ammonium	48,56	AtAMT2	32,38	ammonium	AtAMT2	MESH:D000644	818409(Tax:3702)	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|appos|transporter	Characterization of Arabidopsis AtAMT2 , a novel ammonium transporter in plants .
12481062	0	ammonium	56,64	AtAMT2	32,38	ammonium	AtAMT2	MESH:D000644	818409(Tax:3702)	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|appos|transporter	Characterization of Arabidopsis AtAMT2 , a high-affinity ammonium transporter of the plasma membrane .
9482721	0	ammonium	9,17	MEP2	4,8	ammonium	MEP2	MESH:D000644	855580(Tax:4932)	Chemical	Gene	permease|compound|START_ENTITY permease|compound|END_ENTITY	The MEP2 ammonium permease regulates pseudohyphal differentiation in Saccharomyces_cerevisiae .
17493133	0	ammonium	200,208	Mep2	37,41	ammonium	Mep2	MESH:D000644	855580(Tax:4932)	Chemical	Gene	retrieval|nmod|START_ENTITY play|nmod|retrieval play|nsubj|END_ENTITY	The yeast ammonium transport protein Mep2 and its positive regulator , the Npr1 kinase , play an important role in normal and pseudohyphal growth on various nitrogen media through retrieval of excreted ammonium .
17493133	6	ammonium	1065,1073	Mep2	1028,1032	ammonium	Npr1	MESH:D000644	855538(Tax:4932)	Chemical	Gene	excretion|compound|START_ENTITY counteracts|dobj|excretion counteracts|nsubj|efficiently efficiently|amod|END_ENTITY	This hyperactive Mep2 variant efficiently counteracts ammonium excretion .
21278231	0	ammonium	27,35	Mep2	85,89	ammonium	Mep2	MESH:D000644	855580(Tax:4932)	Chemical	Gene	kinase|acl|START_ENTITY Role|nmod|kinase permease|nsubj|Role permease|dobj|END_ENTITY	Role of the Npr1 kinase in ammonium transport and signaling by the ammonium permease Mep2 in Candida_albicans .
24476960	0	ammonium	76,84	Mep2	71,75	ammonium	Mep2	MESH:D000644	855580(Tax:4932)	Chemical	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	The TORC1 effector kinase Npr1 fine tunes the inherent activity of the Mep2 ammonium transport protein .
16564721	0	ammonium	35,43	RhCG	56,60	ammonium	RhCG	MESH:D000644	56315(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY transporter|nsubj|role transporter|dobj|END_ENTITY	Physiological role of the putative ammonium transporter RhCG in the mouse .
19553567	0	ammonium	59,67	RhCG	29,33	ammonium	RhCG	MESH:D000644	51458	Chemical	Gene	transporter|compound|START_ENTITY comparison|nmod|transporter END_ENTITY|dep|comparison	Functional analysis of human RhCG : comparison with E. _ coli ammonium transporter reveals similarities in the pore and differences in the vestibule .
20927037	0	ammonium	46,54	RhCG	19,23	ammonium	RhCG	MESH:D000644	51458	Chemical	Gene	transport|compound|START_ENTITY perspective|nmod|transport END_ENTITY|dep|perspective	The rhesus protein RhCG : a new perspective in ammonium transport and distal urinary acidification .
19020613	0	ammonium	39,47	Rhcg	25,29	ammonium	Rhcg	MESH:D000644	56315(Tax:10090)	Chemical	Gene	excretion|compound|START_ENTITY END_ENTITY|nmod|excretion	A role for Rhesus factor Rhcg in renal ammonium excretion and male fertility .
11069679	0	ammonium	50,58	mep2	31,35	ammonium	mep2	MESH:D000644	855580(Tax:4932)	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	In vivo N-glycosylation of the mep2 high-affinity ammonium transporter of Saccharomyces_cerevisiae reveals an extracytosolic N-terminus .
6097880	0	ammonium_21-tungsto-9-antimoniate	47,80	DNA_polymerase_alpha	14,34	ammonium 21-tungsto-9-antimoniate	DNA polymerase alpha	null	5422	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activity activity|compound|END_ENTITY	Inhibition of DNA_polymerase_alpha activity by ammonium_21-tungsto-9-antimoniate -LRB- HPA23 -RRB- .
747656	0	ammonium_chloride	15,32	glutaminase	68,79	ammonium chloride	glutaminase	MESH:D000643	2744	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of ammonium_chloride and bicarbonate on the activity of glutaminase in isolated liver mitochondria .
237241	0	ammonium_chloride	22,39	parathyroid_hormone	53,72	ammonium chloride	parathyroid hormone	MESH:D000643	24694(Tax:10116)	Chemical	Gene	ingestion|compound|START_ENTITY ingestion|nmod|END_ENTITY	The effect of chronic ammonium_chloride ingestion on parathyroid_hormone function .
8751832	0	ammonium_metavanadate	66,87	IL-1_alpha	27,37	ammonium metavanadate	IL-1 alpha	MESH:C101036	16175(Tax:10090)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Differential inhibition of IL-1_alpha and TNF-alpha generation by ammonium_metavanadate in murine macrophages .
20160413	0	ammonium_perfluorooctanoate	92,119	peroxisome_proliferator-activated_receptor-alpha	8,56	ammonium perfluorooctanoate	peroxisome proliferator-activated receptor-alpha	MESH:C023036	19013(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Role Role|nmod|END_ENTITY	Role of peroxisome_proliferator-activated_receptor-alpha in hepatobiliary_injury induced by ammonium_perfluorooctanoate in mouse liver .
16946532	0	ammonium_tetrathiotungstate	21,48	tyrosinase	52,62	ammonium tetrathiotungstate	tyrosinase	MESH:C020863	7299	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Inhibitory effect of ammonium_tetrathiotungstate on tyrosinase and its kinetic mechanism .
17222819	0	amodiaquine	10,21	histamine_N-methyltransferase	25,54	amodiaquine	histamine N-methyltransferase	MESH:D000655	140483(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effect of amodiaquine , a histamine_N-methyltransferase inhibitor , on , Propionibacterium_acnes and lipopolysaccharide-induced hepatitis in mice .
10694221	0	amoxapine	53,62	GLYT1	109,114	amoxapine	GLYT1	MESH:D000657	6536	Chemical	Gene	effects|nmod|START_ENTITY mediated|nsubj|effects mediated|nmod|END_ENTITY	Differential effects of the tricyclic antidepressant amoxapine on glycine uptake mediated by the recombinant GLYT1 and GLYT2 glycine transporters .
6818584	0	amoxapine	33,42	Prolactin	0,9	amoxapine	Prolactin	MESH:D000657	5617	Chemical	Gene	effects|nmod|START_ENTITY stimulating|dobj|effects stimulating|nsubj|END_ENTITY	Prolactin stimulating effects of amoxapine and loxapine in psychiatric patients .
7018438	0	amoxapine	14,23	prolactin	48,57	amoxapine	prolactin	MESH:D000657	5617	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|levels levels|compound|END_ENTITY	The effect of amoxapine and imipramine on serum prolactin levels .
26007680	0	amoxicillin	98,109	matrix_metalloproteinases_8_and_9	187,220	amoxicillin	matrix metalloproteinases 8 and 9	MESH:D000658	4317;4318	Chemical	Gene	administration|nmod|START_ENTITY Effect|nmod|administration Effect|nmod|END_ENTITY	Effect of nonsurgical periodontal treatment in conjunction with either systemic administration of amoxicillin and metronidazole or additional photodynamic therapy on the concentration of matrix_metalloproteinases_8_and_9 in gingival crevicular fluid in patients with aggressive_periodontitis .
9272486	0	amperozide	41,51	c-fos	77,82	amperozide	c-fos	MESH:C049058	314322(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	The putative atypical antipsychotic drug amperozide preferentially increases c-fos expression in rat medial prefrontal cortex and lateral septum .
11850146	0	amphetamine	84,95	5-HT2A	0,6	amphetamine	5-HT2A	MESH:D000661	29595(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|END_ENTITY	5-HT2A and 5-HT2C / 2B receptor subtypes modulate dopamine release induced in vivo by amphetamine and morphine in both the rat nucleus accumbens and striatum .
10456690	0	amphetamine	52,63	CYP2D6	15,21	amphetamine	CYP2D6	MESH:D000661	1565	Chemical	Gene	metabolism|nmod|START_ENTITY Involvement|nmod|metabolism Involvement|nmod|END_ENTITY	Involvement of CYP2D6 in the in vitro metabolism of amphetamine , two N-alkylamphetamines and their 4-methoxylated derivatives .
7704609	0	amphetamine	23,34	DA_transporter	57,71	amphetamine	DA transporter	MESH:D000661	24898(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|END_ENTITY	The effect of repeated amphetamine treatment on striatal DA_transporter and rotation in rats .
15602501	0	amphetamine	76,87	Dopamine_transporter	0,20	amphetamine	Dopamine transporter	MESH:D000661	6531	Chemical	Gene	associated|xcomp|START_ENTITY associated|nsubj|gene gene|amod|END_ENTITY	Dopamine_transporter gene associated with diminished subjective response to amphetamine .
12231241	0	amphetamine	112,123	Fos	11,14	amphetamine	Fos	MESH:D000661	314322(Tax:10116)	Chemical	Gene	sensitization|amod|START_ENTITY cortex|nmod|sensitization medial|dobj|cortex medial|nsubj|expression expression|compound|END_ENTITY	Sensitized Fos expression in subterritories of the rat medial prefrontal cortex and nucleus accumbens following amphetamine sensitization as revealed by stereology .
12955385	0	amphetamine	132,143	Fos	117,120	amphetamine	Fos	MESH:D000661	314322(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Interaction Interaction|nmod|systems systems|nmod|expression expression|nmod|END_ENTITY	Interaction between the noradrenergic and serotonergic systems in locomotor_hyperactivity and striatal expression of Fos induced by amphetamine in rats .
1347413	0	amphetamine	35,46	Fos	72,75	amphetamine	Fos	MESH:D000661	314322(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Dopaminergic transplants normalize amphetamine - and apomorphine-induced Fos expression in the 6-hydroxydopamine-lesioned striatum .
1360906	0	amphetamine	96,107	Fos	63,66	amphetamine	Fos	MESH:D000661	314322(Tax:10116)	Chemical	Gene	challenged|nmod|START_ENTITY induce|advcl|challenged induce|dobj|hyperexpression hyperexpression|nmod|protein protein|compound|END_ENTITY	Intrastriatal dopamine-rich grafts induce a hyperexpression of Fos protein when challenged with amphetamine .
14751279	0	amphetamine	57,68	Fos	117,120	amphetamine	Fos	MESH:D000661	314322(Tax:10116)	Chemical	Gene	behavioral|nmod|START_ENTITY behavioral|dep|END_ENTITY	Long-term behavioral and neuronal cross-sensitization to amphetamine induced by repeated brief social defeat stress : Fos in the ventral tegmental area and amygdala .
15464745	0	amphetamine	56,67	Fos	21,24	amphetamine	Fos	MESH:D000661	14281(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY patterns|acl|induced patterns|nmod|expression expression|compound|END_ENTITY	Distinct patterns of Fos expression induced by systemic amphetamine in the striatal complex of C57BL/6JICo and DBA/2JICo inbred strains of mice .
17720257	0	amphetamine	9,20	Fos	80,83	amphetamine	Fos	MESH:D000661	314322(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY enhances|nsubj|administration enhances|dobj|expression expression|compound|END_ENTITY	Repeated amphetamine administration outside the home cage enhances drug-induced Fos expression in rat nucleus accumbens .
18080115	0	amphetamine	9,20	Fos	44,47	amphetamine	Fos	MESH:D000661	314322(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY induces|nsubj|administration induces|dobj|END_ENTITY	Repeated amphetamine administration induces Fos in prefrontal cortical neurons that project to the lateral_hypothalamus but not the nucleus accumbens or basolateral amygdala .
21570990	0	amphetamine	166,177	Fos	25,28	amphetamine	Fos	MESH:D000661	314322(Tax:10116)	Chemical	Gene	sensitization|acl|START_ENTITY accompanies|dobj|sensitization accompanies|nsubj|activation activation|nmod|END_ENTITY	Sensitized activation of Fos and brain-derived_neurotrophic_factor in the medial prefrontal cortex and ventral tegmental area accompanies behavioral sensitization to amphetamine .
8281310	0	amphetamine	49,60	Fos	95,98	amphetamine	Fos	MESH:D000661	314322(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Transection of corticostriatal afferents reduces amphetamine - and apomorphine-induced striatal Fos expression and turning behaviour in unilaterally 6-hydroxydopamine-lesioned rats .
9629957	0	amphetamine	132,143	Fos	117,120	amphetamine	Fos	MESH:D000661	314322(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	The corticostriatal system mediates the `` paradoxical '' contraversive rotation but not the striatal hyperexpression of Fos induced by amphetamine early after 6-hydroxydopamine lesion of the nigrostriatal pathway .
18632938	0	amphetamine	79,90	FosB	6,10	amphetamine	FosB	MESH:D000661	2354	Chemical	Gene	exposure|compound|START_ENTITY mediates|nmod|exposure mediates|nsubj|END_ENTITY	Delta FosB mediates epigenetic desensitization of the c-fos gene after chronic amphetamine exposure .
20974185	0	amphetamine	100,111	FosB	45,49	amphetamine	FosB	MESH:D000661	14282(Tax:10090)	Chemical	Gene	accumulation|acl|START_ENTITY accumulation|nmod|FosB FosB|compound|END_ENTITY	Association between striatal accumulation of FosB / / \ FosB and long-term psychomotor sensitization to amphetamine in mice depends on the genetic background .
20974185	0	amphetamine	100,111	FosB	52,56	amphetamine	FosB	MESH:D000661	14282(Tax:10090)	Chemical	Gene	accumulation|acl|START_ENTITY accumulation|nmod|END_ENTITY	Association between striatal accumulation of FosB / / \ FosB and long-term psychomotor sensitization to amphetamine in mice depends on the genetic background .
11377751	0	amphetamine	24,35	GAP-43	101,107	amphetamine	GAP-43	MESH:D000661	29423(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|nmod|END_ENTITY	Differential effects of amphetamine and phencyclidine on the expression of growth-associated_protein GAP-43 .
10486183	0	amphetamine	11,22	Jun-B	55,60	amphetamine	Jun-B	MESH:D000661	24517(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY Effects|nmod|treatment Effects|nmod|END_ENTITY	Effects of amphetamine and cocaine treatment on c-Fos , Jun-B , and Krox-24 expression in rats with intrastriatal dopaminergic grafts .
20504661	0	amphetamine	66,77	MAO-A	24,29	amphetamine	MAO-A	MESH:D000661	17161(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|inhibition inhibition|nmod|END_ENTITY	Selective inhibition of MAO-A in serotonergic synaptosomes by two amphetamine metabolites , p-hydroxyamphetamine and p-hydroxynorephedrine .
16539683	0	amphetamine	6,17	RGS4	33,37	amphetamine	RGS4	MESH:D000661	29480(Tax:10116)	Chemical	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	Acute amphetamine down-regulates RGS4 mRNA and protein expression in rat forebrain : distinct roles of D1 and D2 dopamine receptors .
10486183	0	amphetamine	11,22	c-Fos	48,53	amphetamine	c-Fos	MESH:D000661	314322(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY Effects|nmod|treatment Effects|nmod|Jun-B Jun-B|compound|END_ENTITY	Effects of amphetamine and cocaine treatment on c-Fos , Jun-B , and Krox-24 expression in rats with intrastriatal dopaminergic grafts .
7606439	0	amphetamine	68,79	c-Fos	0,5	amphetamine	c-Fos	MESH:D000661	314322(Tax:10116)	Chemical	Gene	paired|nmod|START_ENTITY paired|nsubj|induction induction|amod|END_ENTITY	c-Fos induction in response to taste stimuli previously paired with amphetamine or LiCl during taste aversion learning .
8996801	0	amphetamine	55,66	c-Fos	39,44	amphetamine	c-Fos	MESH:D000661	314322(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY END_ENTITY|nmod|treatment	Phenotype of striatal cells expressing c-Fos following amphetamine treatment of rats with intrastriatal dopaminergic grafts .
9507929	0	amphetamine	70,81	c-Fos	34,39	amphetamine	c-Fos	MESH:D000661	314322(Tax:10116)	Chemical	Gene	induction|nmod|START_ENTITY induction|nsubj|patterns patterns|nmod|END_ENTITY	Differential patterns of regional c-Fos induction in the rat brain by amphetamine and the novel wakefulness-promoting agent modafinil .
9519282	0	amphetamine	28,39	c-Fos	90,95	amphetamine	c-Fos	MESH:D000661	314322(Tax:10116)	Chemical	Gene	sensitization|nmod|START_ENTITY accompanied|nsubjpass|sensitization accompanied|nmod|decrease decrease|nmod|number number|nmod|END_ENTITY	Behavioral sensitization to amphetamine is not accompanied by a decrease in the number of c-Fos containing cells in the striatum .
9704883	0	amphetamine	102,113	c-Fos	64,69	amphetamine	c-Fos	MESH:D000661	314322(Tax:10116)	Chemical	Gene	required|nmod|START_ENTITY required|nmod|induction induction|nmod|END_ENTITY	5-HT3_receptor activation is required for induction of striatal c-Fos and phosphorylation of ATF-1 by amphetamine .
11160452	0	amphetamine	78,89	c-fos	45,50	amphetamine	c-fos	MESH:D000661	314322(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY expression|acl|induced expression|amod|END_ENTITY	Environmental novelty differentially affects c-fos mRNA expression induced by amphetamine or cocaine in subregions of the bed nucleus of the stria terminalis and amygdala .
12401322	0	amphetamine	77,88	c-fos	20,25	amphetamine	c-fos	MESH:D000661	2353	Chemical	Gene	pattern|amod|START_ENTITY pattern|nmod|expression expression|amod|END_ENTITY	Distinct pattern of c-fos mRNA expression after systemic and intra-accumbens amphetamine and MK-801 .
18632938	0	amphetamine	79,90	c-fos	54,59	amphetamine	c-fos	MESH:D000661	2353	Chemical	Gene	exposure|compound|START_ENTITY mediates|nmod|exposure mediates|dobj|desensitization desensitization|nmod|gene gene|amod|END_ENTITY	Delta FosB mediates epigenetic desensitization of the c-fos gene after chronic amphetamine exposure .
20406670	0	amphetamine	53,64	c-fos	21,26	amphetamine	c-fos	MESH:D000661	314322(Tax:10116)	Chemical	Gene	doses|nmod|START_ENTITY induction|nmod|doses induction|amod|END_ENTITY	The brain pattern of c-fos induction by two doses of amphetamine suggests different brain processing pathways and minor contribution of behavioural traits .
21093158	0	amphetamine	23,34	c-fos	38,43	amphetamine	c-fos	MESH:D000661	14281(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Differential effect of amphetamine on c-fos expression in female aromatase knockout -LRB- ArKO -RRB- mice compared to wildtype controls .
22063717	0	amphetamine	56,67	c-fos	110,115	amphetamine	c-fos	MESH:D000661	314322(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY phosphorylation|nmod|administration phosphorylation|dep|relationship relationship|nmod|induction induction|amod|END_ENTITY	Brain pattern of histone H3 phosphorylation after acute amphetamine administration : its relationship to brain c-fos induction is strongly dependent on the particular brain area .
7520134	0	amphetamine	88,99	c-fos	57,62	amphetamine	c-fos	MESH:D000661	314322(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Differences Differences|nmod|localization localization|nmod|RNA RNA|amod|END_ENTITY	Differences in the regional and cellular localization of c-fos messenger RNA induced by amphetamine , cocaine and caffeine in the rat .
8943072	0	amphetamine	37,48	c-fos	117,122	amphetamine	c-fos	MESH:D000661	493935(Tax:9685)	Chemical	Gene	targets|nmod|START_ENTITY evidenced|nsubj|targets evidenced|nmod|immunocytochemistry immunocytochemistry|amod|END_ENTITY	Potential brain neuronal targets for amphetamine - , methylphenidate - , and modafinil-induced wakefulness , evidenced by c-fos immunocytochemistry in the cat .
942497	0	amphetamine	113,124	cytochrome_P450	63,78	amphetamine	cytochrome P450	MESH:D000661	4051	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|amod|END_ENTITY	The nature of the `` 455 nm absorbing complex '' formed during the cytochrome_P450 dependent oxidative metabolism of amphetamine .
9655895	0	amphetamine	81,92	dopamine_D4_receptor	12,32	amphetamine	dopamine D4 receptor	MESH:D000661	25432(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of dopamine_D4_receptor in the induction of behavioral sensitization to amphetamine and accompanying biochemical and molecular adaptations .
10037500	0	amphetamine	118,129	dopamine_transporter	83,103	amphetamine	dopamine transporter	MESH:D000661	6531	Chemical	Gene	antagonists|amod|START_ENTITY potential|nmod|antagonists Effects|dep|potential Effects|nmod|analogues analogues|nmod|substrates substrates|nmod|END_ENTITY	Effects of methylphenidate analogues on phenethylamine substrates for the striatal dopamine_transporter : potential as amphetamine antagonists ?
11862367	0	amphetamine	7,18	dopamine_transporter	95,115	amphetamine	dopamine transporter	MESH:D000661	6531	Chemical	Gene	Use|nmod|START_ENTITY associated|nsubjpass|Use associated|nmod|densities densities|compound|END_ENTITY	Use of amphetamine by recreational users of ecstasy -LRB- MDMA -RRB- is associated with reduced striatal dopamine_transporter densities : a -LSB- 123I -RSB- beta-CIT SPECT study -- preliminary report .
12624535	0	amphetamine	23,34	dopamine_transporter	73,93	amphetamine	dopamine transporter	MESH:D000661	24898(Tax:10116)	Chemical	Gene	self-administration|amod|START_ENTITY self-administration|nmod|END_ENTITY	Selective decreases in amphetamine self-administration and regulation of dopamine_transporter function in diabetic rats .
16684900	0	amphetamine	64,75	dopamine_transporter	14,34	amphetamine	dopamine transporter	MESH:D000661	6531	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|trafficking trafficking|compound|END_ENTITY	Regulation of dopamine_transporter trafficking by intracellular amphetamine .
18216205	0	amphetamine	53,64	dopamine_transporter	96,116	amphetamine	dopamine transporter	MESH:D000661	6531	Chemical	Gene	aspects|amod|START_ENTITY aspects|nmod|END_ENTITY	Currents in response to rapid concentration jumps of amphetamine uncover novel aspects of human dopamine_transporter function .
23612789	0	amphetamine	95,106	dopamine_transporter	30,50	amphetamine	dopamine transporter	MESH:D000661	24898(Tax:10116)	Chemical	Gene	endocytosis|amod|START_ENTITY pathways|nmod|endocytosis pathways|nsubj|Differential Differential|nmod|END_ENTITY	Differential targeting of the dopamine_transporter to recycling or degradative pathways during amphetamine - or PKC-regulated endocytosis in dopamine neurons .
26553986	0	amphetamine	123,134	dopamine_transporter	54,74	amphetamine	dopamine transporter	MESH:D000661	13162(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|amod|END_ENTITY	Amphetamine activates Rho GTPase signaling to mediate dopamine_transporter internalization and acute behavioral effects of amphetamine .
7870046	0	amphetamine	47,58	dopamine_transporter	85,105	amphetamine	dopamine transporter	MESH:D000661	6531	Chemical	Gene	actions|nmod|START_ENTITY Mechanism|nmod|actions Mechanism|dep|END_ENTITY	Mechanism of the dopamine-releasing actions of amphetamine and cocaine : plasmalemmal dopamine_transporter versus vesicular monoamine transporter .
9387873	0	amphetamine	110,121	dopamine_transporter	14,34	amphetamine	dopamine transporter	MESH:D000661	24898(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY mRNAs|nmod|administration mRNAs|nsubj|Expression Expression|nmod|END_ENTITY	Expression of dopamine_transporter and vesicular_monoamine_transporter_2 mRNAs in rat midbrain after repeated amphetamine administration .
9482784	0	amphetamine	14,25	dopamine_transporter	62,82	amphetamine	dopamine transporter	MESH:D000661	13162(Tax:10090)	Chemical	Gene	action|amod|START_ENTITY Mechanisms|nmod|action revealed|nsubj|Mechanisms revealed|nmod|mice mice|acl|lacking lacking|dobj|END_ENTITY	Mechanisms of amphetamine action revealed in mice lacking the dopamine_transporter .
19890266	0	amphetamine	103,114	fatty_acid_amide_hydrolase	29,55	amphetamine	fatty acid amide hydrolase	MESH:D000661	2166	Chemical	Gene	influence|advcl|START_ENTITY influence|nsubj|polymorphisms polymorphisms|amod|END_ENTITY	More aroused , less fatigued : fatty_acid_amide_hydrolase gene polymorphisms influence acute response to amphetamine .
999450	0	amphetamine	36,47	growth_hormone	8,22	amphetamine	growth hormone	MESH:D000661	2688	Chemical	Gene	responses|acl|START_ENTITY responses|compound|END_ENTITY	Reduced growth_hormone responses to amphetamine in `` endogenous '' depressive patients : studies in normal , `` reactive '' and `` endogenous '' depressive , schizophrenic , and chronic alcoholic subjects .
15637639	0	amphetamine	68,79	neurotensin	11,22	amphetamine	neurotensin	MESH:D000661	299757(Tax:10116)	Chemical	Gene	contributes|xcomp|START_ENTITY contributes|nsubj|END_ENTITY	Endogenous neurotensin in the ventral tegmental area contributes to amphetamine behavioral sensitization .
12425947	0	amphetamine	53,64	prion_protein	103,116	amphetamine	prion protein	MESH:D000661	19122(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|acl|lacking lacking|dobj|END_ENTITY	Decreased_hyperlocomotion induced by MK-801 , but not amphetamine and caffeine in mice lacking cellular prion_protein -LRB- PrP -LRB- C -RRB- -RRB- .
22348072	0	amphitrite	104,114	calmodulin	14,24	amphitrite	calmodulin	null	808	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of calmodulin and myosin_light_chain_kinase during larval settlement of the Barnacle Balanus amphitrite .
24891430	0	amphotericin_B	81,95	CSF	27,30	amphotericin B	CSF	MESH:D000666	1437	Chemical	Gene	administration|nmod|START_ENTITY END_ENTITY|nmod|administration	Amphotericin_B transfer to CSF following intravenous administration of liposomal amphotericin_B .
10564063	0	amphotericin_B	29,43	HDL3	69,73	amphotericin B	HDL3	MESH:D000666	53369	Chemical	Gene	complex|amod|START_ENTITY complex|nmod|END_ENTITY	Preferential distribution of amphotericin_B lipid complex into human HDL3 is a consequence of high density lipoprotein coat lipid content .
1492075	0	amphotericin_B	10,24	dopachrome_tautomerase	28,50	amphotericin B	dopachrome tautomerase	MESH:D000666	13190(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	Effect of amphotericin_B on dopachrome_tautomerase activity and other melanogenic parameters in cultured B16/F10 melanoma cells .
7963740	0	amphotericin_B	57,71	interferon-gamma	20,36	amphotericin B	interferon-gamma	MESH:D000666	15978(Tax:10090)	Chemical	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	In vivo activity of interferon-gamma in combination with amphotericin_B in the treatment of experimental cryptococcosis .
15025631	0	amphotericin_B	17,31	relaxin-2	68,77	amphotericin B	relaxin-2	MESH:D000666	6019	Chemical	Gene	influence|nmod|START_ENTITY influence|nmod|END_ENTITY	The influence of amphotericin_B and neomycin on the effect of human relaxin-2 on foetal membranes and isolated myometrium .
2503565	0	ampicillin	85,95	beta-lactamase	12,26	ampicillin	beta-lactamase	MESH:D000667	13913583	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of beta-lactamase in mixed_infections in mice in relation to treatment with ampicillin .
3498359	0	ampicillin	101,111	beta-lactamase	54,68	ampicillin	beta-lactamase	MESH:D000667	13915111	Chemical	Gene	resistance|compound|START_ENTITY resistance|amod|END_ENTITY	Evaluation of Hemophilus type B systemic isolates for beta-lactamase and non-beta-lactamase mediated ampicillin resistance and for susceptibility to other antimicrobial agents .
14704253	0	ampicillin	69,79	interleukin-6	23,36	ampicillin	interleukin-6	MESH:D000667	3569	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of amniotic interleukin-6 and prostaglandin_E2 release by ampicillin .
10952482	0	amprenavir	61,71	CYP3A	43,48	amprenavir	CYP3A	MESH:C095108	1576	Chemical	Gene	vitro|nmod|START_ENTITY END_ENTITY|acl|vitro	Potent mechanism-based inhibition of human CYP3A in vitro by amprenavir and ritonavir : comparison with ketoconazole .
8812741	0	amrinone	40,48	Growth_factor	0,13	amrinone	Growth factor	MESH:D000676	79215(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Growth_factor expression and effects of amrinone in monocrotaline-induced pulmonary_hypertension in rats .
1611705	0	amrinone	10,18	tumor_necrosis_factor	22,43	amrinone	tumor necrosis factor	MESH:D000676	21926(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|production production|compound|END_ENTITY	Effect of amrinone on tumor_necrosis_factor production in endotoxic_shock .
18054347	0	amrubicin	59,68	P-glycoprotein	8,22	amrubicin	P-glycoprotein	MESH:C055866	5243	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of P-glycoprotein in accumulation and cytotoxicity of amrubicin and amrubicinol in MDR1 gene-transfected LLC-PK1 cells and human A549 lung_adenocarcinoma cells .
23328865	0	amrubicin	20,29	S-1	50,53	amrubicin	S-1	MESH:C055866	5707	Chemical	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	Phase I/II study of amrubicin in combination with S-1 as second-line chemotherapy for non-small-cell_lung_cancer without EGFR mutation .
10920913	0	amsacrine	45,54	bcl-2	73,78	amsacrine	bcl-2	MESH:D000677	596	Chemical	Gene	START_ENTITY|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Studies on programmed_cell_death induced by amsacrine and expression of bcl-2 in leukemia cell lines -RSB- .
1333205	0	amsacrine	24,33	myeloperoxidase	59,74	amsacrine	myeloperoxidase	MESH:D000677	4353	Chemical	Gene	metabolism|nmod|START_ENTITY END_ENTITY|nsubj|metabolism	Oxidative metabolism of amsacrine by the neutrophil enzyme myeloperoxidase .
26150007	0	amycenone	11,20	interleukin-10	65,79	amycenone	interleukin-10	null	16153(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|nmod|END_ENTITY	Effects of amycenone on serum levels of tumor_necrosis_factor-a , interleukin-10 , and depression-like behavior in mice after lipopolysaccharide administration .
18955812	0	amygdalin	21,30	TNF-alpha	63,72	amygdalin	TNF-alpha	MESH:D000678	24835(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Inhibitory effect of amygdalin on lipopolysaccharide-inducible TNF-alpha and IL-1beta mRNA expression and carrageenan-induced rat arthritis .
25818779	0	anacardic_acid	11,25	Hsp90	29,34	anacardic acid	Hsp90	MESH:C088115	3320	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	-LSB- Effect of anacardic_acid , a Hsp90 inhibitor , on proliferation , invasion and migration_of_breast_cancer MDA-MB-231 cells -RSB- .
19004846	0	anacetrapib	63,74	CETP	121,125	anacetrapib	CETP	MESH:C530884	1071	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|appos|END_ENTITY	Assessment of the CYP3A-mediated drug interaction potential of anacetrapib , a potent cholesteryl_ester_transfer_protein -LRB- CETP -RRB- inhibitor , in healthy volunteers .
18068514	0	anacetrapib	60,71	cholesteryl_ester_transfer_protein	14,48	anacetrapib	cholesteryl ester transfer protein	MESH:C530884	1071	Chemical	Gene	two|dep|START_ENTITY phase|dep|two studies|dep|phase studies|nsubj|Effect Effect|nmod|inhibitor inhibitor|compound|END_ENTITY	Effect of the cholesteryl_ester_transfer_protein inhibitor , anacetrapib , on lipoproteins in patients with dyslipidaemia and on 24-h ambulatory blood pressure in healthy individuals : two double-blind , randomised placebo-controlled phase I studies .
19004846	0	anacetrapib	63,74	cholesteryl_ester_transfer_protein	85,119	anacetrapib	cholesteryl ester transfer protein	MESH:C530884	1071	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Assessment of the CYP3A-mediated drug interaction potential of anacetrapib , a potent cholesteryl_ester_transfer_protein -LRB- CETP -RRB- inhibitor , in healthy volunteers .
20016053	0	anacetrapib	28,39	cholesteryl_ester_transfer_protein	66,100	anacetrapib	cholesteryl ester transfer protein	MESH:C530884	1071	Chemical	Gene	Metabolism|nmod|START_ENTITY Metabolism|appos|inhibitor inhibitor|nmod|END_ENTITY	Metabolism and excretion of anacetrapib , a novel inhibitor of the cholesteryl_ester_transfer_protein , in humans .
23436178	0	anagliptin	31,41	dipeptidyl_peptidase-4	51,73	anagliptin	dipeptidyl peptidase-4	null	25253(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Pharmacokinetic disposition of anagliptin , a novel dipeptidyl_peptidase-4 inhibitor , in rats and dogs .
12111780	0	anagrelide	95,105	TGFbeta	19,26	anagrelide	TGFbeta	MESH:C021139	7040	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|Variation Variation|nmod|END_ENTITY	Variation of PDGF , TGFbeta , and bFGF levels in essential_thrombocythemia patients treated with anagrelide .
15682418	0	anagrelide	102,112	TGFbeta	16,23	anagrelide	TGFbeta	MESH:C021139	7040	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|END_ENTITY	PDGF-A , PDGF-B , TGFbeta , and bFGF mRNA levels in patients with essential_thrombocythemia treated with anagrelide .
11982628	0	anandamide	23,33	CB1	48,51	anandamide	CB1	MESH:C078814	12801(Tax:10090)	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|nmod|mice mice|nummod|END_ENTITY	Age-related changes of anandamide metabolism in CB1 cannabinoid receptor knockout mice : correlation with behaviour .
12815050	1	anandamide	65,75	CB1	119,122	anandamide	CB1	MESH:C078814	1268	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|inhibition inhibition|nummod|END_ENTITY	Evidence that anandamide inhibits epidermal differentiation through CB1 receptor-dependent inhibition of protein kinase C , activation protein-1 , and transglutaminase .
14504685	0	anandamide	22,32	CB1	59,62	anandamide	CB1	MESH:C078814	25248(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Hypotensive effect of anandamide through the activation of CB1 and VR1 spinal receptors in urethane-anesthetized rats .
14688442	0	anandamide	28,38	CB1	92,95	anandamide	CB1	MESH:C078814	12801(Tax:10090)	Chemical	Gene	cannabinoid|appos|START_ENTITY activates|nsubj|cannabinoid activates|dobj|axis axis|nmod|mice mice|nummod|END_ENTITY	The endogenous cannabinoid , anandamide , activates the hypothalamo-pituitary-adrenal axis in CB1 cannabinoid receptor knockout mice .
15209515	0	anandamide	139,149	CB1	123,126	anandamide	CB1	MESH:C078814	12801(Tax:10090)	Chemical	Gene	uptake|amod|START_ENTITY receptor|nmod|uptake receptor|compound|END_ENTITY	Comparison of anandamide transport in FAAH wild-type and knockout neurons : evidence for contributions by both FAAH and the CB1 receptor to anandamide uptake .
16534762	0	anandamide	76,86	CB1	39,42	anandamide	CB1	MESH:C078814	1268	Chemical	Gene	mimetics|compound|START_ENTITY affinity|nmod|mimetics affinity|compound|END_ENTITY	Synthesis , conformational analysis and CB1 binding affinity of hairpin-like anandamide pseudopeptide mimetics .
17217945	0	anandamide	14,24	CB1	120,123	anandamide	CB1	MESH:C078814	12801(Tax:10090)	Chemical	Gene	effects|nmod:poss|START_ENTITY Assessment|nmod|effects deficient_of_both|nsubj|Assessment deficient_of_both|dobj|receptors receptors|compound|END_ENTITY	Assessment of anandamide 's pharmacological effects in mice deficient_of_both fatty_acid_amide_hydrolase and cannabinoid CB1 receptors .
17912052	0	anandamide	58,68	CB1	35,38	anandamide	CB1	MESH:C078814	25248(Tax:10116)	Chemical	Gene	analog|compound|START_ENTITY receptor|dep|analog receptor|compound|END_ENTITY	Effects of AM1346 , a high-affinity CB1 receptor selective anandamide analog , on open-field behavior in rats .
18302793	0	anandamide	55,65	CB1	85,88	anandamide	CB1	MESH:C078814	1268	Chemical	Gene	prediction|nmod|START_ENTITY analogs|nsubj|prediction analogs|nmod|receptor receptor|compound|END_ENTITY	Binding mode prediction of conformationally restricted anandamide analogs within the CB1 receptor .
21383171	0	anandamide	19,29	CB1	105,108	anandamide	CB1	MESH:C078814	12801(Tax:10090)	Chemical	Gene	synthesis|amod|START_ENTITY Hyperactivation|nmod|synthesis Hyperactivation|nmod|receptors receptors|appos|END_ENTITY	Hyperactivation of anandamide synthesis and regulation of cell-cycle progression via cannabinoid type 1 -LRB- CB1 -RRB- receptors in the regenerating liver .
21719698	0	anandamide	66,76	CB1	34,37	anandamide	CB1	MESH:C078814	1268	Chemical	Gene	activated|nmod|START_ENTITY activated|nsubjpass|receptors receptors|appos|END_ENTITY	Intracellular cannabinoid type 1 -LRB- CB1 -RRB- receptors are activated by anandamide .
22394688	0	anandamide	48,58	CB1	21,24	anandamide	CB1	MESH:C078814	25248(Tax:10116)	Chemical	Gene	modulation|amod|START_ENTITY role|nmod|modulation role|nmod|receptors receptors|compound|END_ENTITY	Differential role of CB1 and TRPV1 receptors on anandamide modulation of defensive responses induced by nitric_oxide in the dorsolateral periaqueductal gray .
24648181	0	anandamide	24,34	CB1	77,80	anandamide	CB1	MESH:C078814	12801(Tax:10090)	Chemical	Gene	Elevation|nmod|START_ENTITY impairs|nsubj|Elevation impairs|nmod|receptor receptor|nummod|END_ENTITY	Elevation of endogenous anandamide impairs LTP , learning , and memory through CB1 receptor signaling in mice .
24671517	0	anandamide	4,14	CB1	84,87	anandamide	CB1	MESH:C078814	25248(Tax:10116)	Chemical	Gene	doses|compound|START_ENTITY facilitate|nsubj|doses facilitate|nmod|activation activation|nmod|receptors receptors|nummod|END_ENTITY	Low anandamide doses facilitate male rat sexual behaviour through the activation of CB1 receptors .
27062913	0	anandamide	34,44	CB1	0,3	anandamide	CB1	MESH:C078814	1268	Chemical	Gene	signalling|compound|START_ENTITY reduces|nsubj|signalling cannabinoid|ccomp|reduces cannabinoid|nsubj|END_ENTITY	CB1 cannabinoid receptor-mediated anandamide signalling reduces the defensive behaviour evoked through GABAA receptor blockade in the dorsomedial division of the ventromedial hypothalamus .
7589169	0	anandamide	86,96	CB1	32,35	anandamide	CB1	MESH:C078814	25248(Tax:10116)	Chemical	Gene	action|nmod|START_ENTITY receptor|nmod|action receptor|compound|END_ENTITY	Novel antagonist implicates the CB1 cannabinoid receptor in the hypotensive action of anandamide .
8614278	0	anandamide	55,65	CB1	82,85	anandamide	CB1	MESH:C078814	25248(Tax:10116)	Chemical	Gene	analog|nmod|START_ENTITY effects|appos|analog effects|appos|receptor receptor|compound|END_ENTITY	Extrapyramidal effects of methanandamide , an analog of anandamide , the endogenous CB1 receptor ligand .
8751088	0	anandamide	66,76	CB1	143,146	anandamide	CB1	MESH:C078814	25248(Tax:10116)	Chemical	Gene	slices|nmod|START_ENTITY potentiation|nmod|slices Inhibition|nmod|potentiation Inhibition|dep|reversal reversal|nmod|SR141716_A SR141716_A|appos|antagonist antagonist|nmod|receptors receptors|nummod|END_ENTITY	Inhibition of long-term potentiation in rat hippocampal slices by anandamide and WIN55212-2 : reversal by SR141716_A , a selective antagonist of CB1 cannabinoid receptors .
9822555	12	anandamide	1578,1588	CB1	1614,1617	anandamide	CB1	MESH:C078814	1268	Chemical	Gene	START_ENTITY|appos|analogue analogue|nmod|affinity affinity|compound|END_ENTITY	CM was also applied to sn-2-arachidonylglycerol -LRB- 2-AG -RRB- , another endogenous CB ligand ; to a 1,1-dimethylheptyl derivative of anandamide , an analogue with higher CB1 affinity than anandamide ; and to N - -LRB- 2-hydroxyethyl -RRB- prostaglandin-B2-ethanolamide -LRB- PGB2-EA -RRB- , a prostanoid ligand which does not bind to CB1 .
9822555	12	anandamide	1632,1642	CB1	1614,1617	anandamide	CB1	MESH:C078814	1268	Chemical	Gene	affinity|nmod|START_ENTITY affinity|compound|END_ENTITY	CM was also applied to sn-2-arachidonylglycerol -LRB- 2-AG -RRB- , another endogenous CB ligand ; to a 1,1-dimethylheptyl derivative of anandamide , an analogue with higher CB1 affinity than anandamide ; and to N - -LRB- 2-hydroxyethyl -RRB- prostaglandin-B2-ethanolamide -LRB- PGB2-EA -RRB- , a prostanoid ligand which does not bind to CB1 .
9876105	0	anandamide	44,54	CB1	76,79	anandamide	CB1	MESH:C078814	1268	Chemical	Gene	arachidonylethanolamide|appos|START_ENTITY analogues|nmod|arachidonylethanolamide analogues|dep|affinities affinities|nmod|END_ENTITY	Novel analogues of arachidonylethanolamide -LRB- anandamide -RRB- : affinities for the CB1 and CB2 cannabinoid receptors and metabolic stability .
16472800	0	anandamide	78,88	CGRP	8,12	anandamide	CGRP	MESH:C078814	24241(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of CGRP and GABA in the hypotensive effect of intrathecally administered anandamide to anesthetized rats .
20702771	0	anandamide	98,108	CYP3A4	62,68	anandamide	CYP3A4	MESH:C078814	1576	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of a commonly occurring genetic polymorphism of human CYP3A4 -LRB- I118V -RRB- on the metabolism of anandamide .
14729864	0	anandamide	30,40	FAAH	44,48	anandamide	FAAH	MESH:C078814	14073(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|compound|END_ENTITY	Formation of prostamides from anandamide in FAAH knockout mice analyzed by HPLC with tandem mass spectrometry .
24466356	0	anandamide	45,55	FAAH	74,78	anandamide	FAAH	MESH:C078814	2166	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Ketoconazole inhibits the cellular uptake of anandamide via inhibition of FAAH at pharmacologically relevant concentrations .
19647110	0	anandamide	12,22	GPR55	3,8	anandamide	GPR55	MESH:C078814	9290	Chemical	Gene	receptor|amod|START_ENTITY receptor|nsubj|END_ENTITY	Is GPR55 an anandamide receptor ?
22568077	0	anandamide	12,22	IL-11	26,31	anandamide	IL-11	MESH:C078814	3589	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	-LSB- Effects of anandamide on IL-11 production through the TRPV1 of human periodontal ligament cells -RSB- .
15121805	0	anandamide	43,53	TRPV1	57,62	anandamide	TRPV1	MESH:C078814	193034(Tax:10090)	Chemical	Gene	profile|nmod|START_ENTITY profile|nmod|mice mice|compound|END_ENTITY	Haemodynamic profile and responsiveness to anandamide of TRPV1 receptor knock-out mice .
16338989	0	anandamide	45,55	TRPV1	177,182	anandamide	TRPV1	MESH:C078814	100771135	Chemical	Gene	desensitization|nmod|START_ENTITY desensitization|acl|expressing expressing|dobj|END_ENTITY	Phosphorylation-dependent desensitization by anandamide of vanilloid_receptor-1 -LRB- TRPV1 -RRB- function in rat skeletal muscle arterioles and in Chinese_hamster ovary cells expressing TRPV1 .
16338989	0	anandamide	45,55	TRPV1	81,86	anandamide	TRPV1	MESH:C078814	83810(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|function function|appos|END_ENTITY	Phosphorylation-dependent desensitization by anandamide of vanilloid_receptor-1 -LRB- TRPV1 -RRB- function in rat skeletal muscle arterioles and in Chinese_hamster ovary cells expressing TRPV1 .
17533116	0	anandamide	61,71	TRPV1	12,17	anandamide	TRPV1	MESH:C078814	7442	Chemical	Gene	effect|nmod|START_ENTITY receptors|nmod|effect receptors|nummod|END_ENTITY	The role of TRPV1 receptors in the antinociceptive effect of anandamide at spinal level .
21076423	0	anandamide	31,41	TRPV1	0,5	anandamide	TRPV1	MESH:C078814	83810(Tax:10116)	Chemical	Gene	activation|nmod|START_ENTITY activation|nummod|END_ENTITY	TRPV1 activation by endogenous anandamide triggers postsynaptic long-term depression in dentate gyrus .
22568077	0	anandamide	12,22	TRPV1	55,60	anandamide	TRPV1	MESH:C078814	7442	Chemical	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	-LSB- Effects of anandamide on IL-11 production through the TRPV1 of human periodontal ligament cells -RSB- .
22861649	0	anandamide	72,82	TRPV1	38,43	anandamide	TRPV1	MESH:C078814	83810(Tax:10116)	Chemical	Gene	comparison|nmod|START_ENTITY channels|nmod|comparison channels|nummod|END_ENTITY	A re-evaluation of 9-HODE activity at TRPV1 channels in comparison with anandamide : enantioselectivity and effects at other TRP channels and in sensory neurons .
23340220	0	anandamide	31,41	TRPV1	107,112	anandamide	TRPV1	MESH:C078814	83810(Tax:10116)	Chemical	Gene	vasorelaxation|amod|START_ENTITY 17b-estradiol|nmod|vasorelaxation Modulation|nmod|17b-estradiol Modulation|dep|role role|nmod|END_ENTITY	Modulation by 17b-estradiol of anandamide vasorelaxation in normotensive and hypertensive rats : a role for TRPV1 but not fatty_acid_amide hydrolase .
25395667	0	anandamide	34,44	TRPV1	0,5	anandamide	TRPV1	MESH:C078814	7442	Chemical	Gene	uptake|nmod|START_ENTITY mediates|dobj|uptake mediates|nsubj|END_ENTITY	TRPV1 mediates cellular uptake of anandamide and thus promotes endothelial cell proliferation and network-formation .
11278420	0	anandamide	16,26	VR1	40,43	anandamide	VR1	MESH:C078814	56664	Chemical	Gene	START_ENTITY|nmod|receptors receptors|compound|END_ENTITY	The activity of anandamide at vanilloid VR1 receptors requires facilitated transport across the cell membrane and is limited by intracellular metabolism .
11413249	0	anandamide	49,59	VR1	24,27	anandamide	VR1	MESH:C078814	7442	Chemical	Gene	effects|nmod|START_ENTITY receptor|dep|effects receptor|appos|END_ENTITY	The vanilloid receptor -LRB- VR1 -RRB- - mediated effects of anandamide are potently enhanced by the cAMP-dependent protein kinase .
24813296	0	anandamide	6,16	cannabinoid_receptor_1	31,53	anandamide	cannabinoid receptor 1	MESH:C078814	25248(Tax:10116)	Chemical	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Vagal anandamide signaling via cannabinoid_receptor_1 contributes to luminal 5-HT modulation of visceral nociception in rats .
18698000	0	anandamide	20,30	cytochrome_P450_2D6	72,91	anandamide	cytochrome P450 2D6	MESH:C078814	1565	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	The endocannabinoid anandamide is a substrate for the human polymorphic cytochrome_P450_2D6 .
12910401	0	anandamide	46,56	endothelin-1	68,80	anandamide	endothelin-1	MESH:C078814	100009270(Tax:9986)	Chemical	Gene	administration|nmod|START_ENTITY attenuates|nsubj|administration attenuates|dobj|vasospasm vasospasm|amod|END_ENTITY	Intra-arterial simultaneous administration of anandamide attenuates endothelin-1 induced vasospasm in rabbit basilar arteries .
9738948	0	anandamide	27,37	interleukin-6	50,63	anandamide	interleukin-6	MESH:C078814	16193(Tax:10090)	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|production production|amod|END_ENTITY	The endogenous cannabinoid anandamide potentiates interleukin-6 production by astrocytes infected with Theiler 's murine encephalomyelitis virus by a receptor-mediated pathway .
15280536	0	anandamide	25,35	luteinizing_hormone-releasing_hormone	39,76	anandamide	luteinizing hormone-releasing hormone	MESH:C078814	25194(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	The inhibitory effect of anandamide on luteinizing_hormone-releasing_hormone secretion is reversed by estrogen .
12578974	0	anandamide	14,24	prolactin	28,37	anandamide	prolactin	MESH:C078814	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	The effect of anandamide on prolactin secretion is modulated by estrogen .
16338989	0	anandamide	45,55	vanilloid_receptor-1	59,79	anandamide	vanilloid receptor-1	MESH:C078814	83810(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|function function|amod|END_ENTITY	Phosphorylation-dependent desensitization by anandamide of vanilloid_receptor-1 -LRB- TRPV1 -RRB- function in rat skeletal muscle arterioles and in Chinese_hamster ovary cells expressing TRPV1 .
9619713	0	anastrozole	45,56	prolactin	72,81	anastrozole	prolactin	MESH:C090450	5617	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Clinical efficacy of the aromatase inhibitor anastrozole in relation to prolactin secretion in heavily pretreated metastatic breast_cancer .
21287342	0	and_eticlopride	86,101	dopamine_D2_receptor	105,125	and eticlopride	dopamine D2 receptor	null	13489(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Behavioral economics of food reinforcement and the effects of prefeeding , extinction , and_eticlopride in dopamine_D2_receptor mutant mice .
11699123	0	androgen	72,80	5_alpha-reductase	28,45	androgen	5 alpha-reductase	CHEBI:50113	6715	Chemical	Gene	pathways|nmod|START_ENTITY pathways|amod|END_ENTITY	Altered balance between the 5_alpha-reductase and aromatase pathways of androgen metabolism during controlled ovarian_hyperstimulation with human menopausal gonadotropins .
11420057	0	androgen	60,68	5alpha-reductase	69,85	androgen	5alpha-reductase	CHEBI:50113	6715	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	The effects of human mast-cell products and of phenytoin on androgen 5alpha-reductase expression in human_gingival_fibroblasts .
14716738	0	androgen	59,67	5alpha-reductase	22,38	androgen	5alpha-reductase	CHEBI:50113	6715	Chemical	Gene	action|compound|START_ENTITY inhibits|dobj|action inhibits|nsubj|Dutasteride Dutasteride|appos|inhibitor inhibitor|amod|END_ENTITY	Dutasteride , the dual 5alpha-reductase inhibitor , inhibits androgen action and promotes cell death in the LNCaP_prostate_cancer cell line .
17339601	0	androgen	29,37	5alpha-reductase	98,114	androgen	5alpha-reductase	CHEBI:50113	6715	Chemical	Gene	modulators|compound|START_ENTITY modulators|parataxis|overlooking overlooking|dobj|role role|nmod|END_ENTITY	Ockham 's razor and selective androgen receptor modulators -LRB- SARMs -RRB- : are we overlooking the role of 5alpha-reductase ?
17657621	0	androgen	79,87	5alpha-reductase	50,66	androgen	5alpha-reductase	CHEBI:50113	6715	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	The combined effects of TGF-beta , IGF and PDGF on 5alpha-reductase activity on androgen substrates in human gingival tissue .
18503427	0	androgen	158,166	5alpha-reductase	21,37	androgen	5alpha-reductase	CHEBI:50113	6715	Chemical	Gene	modulators|compound|START_ENTITY screening|dobj|modulators model|acl|screening Expression|dep|model Expression|nmod|type type|amod|END_ENTITY	Expression of type 1 5alpha-reductase and metabolism of testosterone in reconstructed human epidermis -LRB- SkinEthic -LRB- R -RRB- -RRB- : a new model for screening skin-targeted androgen modulators .
20124490	0	androgen	19,27	5alpha-reductase	63,79	androgen	5alpha-reductase	CHEBI:50113	6715	Chemical	Gene	response|compound|START_ENTITY response|nmod|epithelium epithelium|nmod|inhibition inhibition|amod|END_ENTITY	Variability in the androgen response of prostate epithelium to 5alpha-reductase inhibition : implications for prostate_cancer chemoprevention .
665726	0	androgen	117,125	5alpha-reductase	0,16	androgen	5alpha-reductase	CHEBI:50113	6715	Chemical	Gene	insensitivity|amod|START_ENTITY patients|nmod|insensitivity fibroblasts|nmod|patients fibroblasts|nsubj|activity activity|amod|END_ENTITY	5alpha-reductase activity of genital and nongenital skin fibroblasts from patients with 5alpha-reductase_deficiency , androgen insensitivity , or unknown forms of male_pseudohermaphroditism .
9219921	0	androgen	94,102	5alpha-reductase	113,129	androgen	5alpha-reductase	CHEBI:50113	6715	Chemical	Gene	blockade|compound|START_ENTITY blockade|acl|-LSB- -LSB-|dobj|inhibition inhibition|amod|END_ENTITY	4-Methyl-3-oxo-4-aza-5alpha-androst-1-ene-17beta-N-aryl-carboxamides : an approach to combined androgen blockade -LSB- 5alpha-reductase inhibition with androgen_receptor binding in vitro -RSB- .
1242082	0	androgen	55,63	ABP	81,84	androgen	ABP	CHEBI:50113	100009224(Tax:9986)	Chemical	Gene	START_ENTITY|dobj|protein protein|appos|END_ENTITY	Purification and characterization of rabbit testicular androgen binding protein -LRB- ABP -RRB- .
18322	0	androgen	11,19	ABP	37,40	androgen	ABP	CHEBI:50113	24775(Tax:10116)	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Testicular androgen binding protein -LRB- ABP -RRB- - a parameter of Sertoli cell secretory function .
16233969	0	androgen	43,51	ACTH	67,71	androgen	ACTH	CHEBI:50113	403659(Tax:9615)	Chemical	Gene	concentrations|compound|START_ENTITY concentrations|compound|END_ENTITY	Cortisol , aldosterone , cortisol precursor , androgen and endogenous ACTH concentrations in dogs with pituitary-dependant hyperadrenocorticism treated with trilostane .
21868574	0	androgen	126,134	ADTRP	14,19	androgen	ADTRP	CHEBI:50113	84830	Chemical	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Novel protein ADTRP regulates TFPI expression and function in human endothelial cells in normal conditions and in response to androgen .
15474988	5	androgen	683,691	AR	770,772	androgen	AR	CHEBI:50113	367	Chemical	Gene	require|dobj|START_ENTITY require|xcomp|induce induce|dobj|S100P S100P|nmod|cells cells|acl:relcl|express express|dobj|androgen_receptor androgen_receptor|appos|END_ENTITY	IL6 did not require androgen to induce S100P in these cells , which express a functional androgen_receptor -LRB- AR -RRB- .
19771394	0	androgen	50,58	AR	91,93	androgen	AR	CHEBI:50113	367	Chemical	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	NBBS isolated from Pygeum africanum bark exhibits androgen antagonistic activity , inhibits AR nuclear translocation and prostate_cancer cell growth .
21796524	2	androgen	521,529	AR	496,498	androgen	AR	CHEBI:50113	367	Chemical	Gene	retains|dobj|START_ENTITY retains|nsubj|END_ENTITY	The functional importance of the AR N/C interaction is supported by naturally occurring loss-of-function AR AF2 mutations where AR retains high-affinity androgen binding but is defective in AR FXXLF motif binding .
23877345	0	androgen	18,26	AR	5,7	androgen	AR	CHEBI:50113	367	Chemical	Gene	deprivation|compound|START_ENTITY leads|nsubj|deprivation leads|nmod|END_ENTITY	From AR to c-Met : androgen deprivation leads to a signaling pathway switch in prostate_cancer cells .
26793880	1	androgen	188,196	AR	93,95	androgen	AR	CHEBI:50113	367	Chemical	Gene	therapy|compound|START_ENTITY signaling|nmod|therapy AR_axis|acl|signaling role|dep|AR_axis has|dobj|role has|nsubj|Androgen_receptor Androgen_receptor|appos|END_ENTITY	Androgen_receptor -LRB- AR -RRB- has a critical role in prostate_cancer -LRB- PCa -RRB- progression and targeting AR_axis signaling by androgen deprivation therapy is a standard treatment for advanced PCa .
6523537	0	androgen	124,132	AR	27,29	androgen	AR	CHEBI:50113	367	Chemical	Gene	molecules|amod|START_ENTITY reaction|nmod|molecules characterization|nmod|reaction androgen_receptor|dep|characterization androgen_receptor|appos|END_ENTITY	Cytosol androgen_receptor -LRB- AR -RRB- in human skin fibroblasts : characterization of the binding reaction and differentiation from androgen binding molecules of lower affinity .
23088973	0	androgen	21,29	AR-V1	47,52	androgen	AR-V1	CHEBI:50113	64801	Chemical	Gene	variant|compound|START_ENTITY variant|amod|END_ENTITY	Transcript levels of androgen receptor variant AR-V1 or AR-V7 do not predict recurrence in patients with prostate_cancer at indeterminate risk for progression .
11061898	0	androgen	90,98	Androgen_receptor	0,17	androgen	Androgen receptor	CHEBI:50113	367	Chemical	Gene	blockade|compound|START_ENTITY predicts|nmod|blockade predicts|nsubj|amplification amplification|amod|END_ENTITY	Androgen_receptor gene amplification at primary progression predicts response to combined androgen blockade as second line therapy for advanced prostate_cancer .
11223178	0	androgen	54,62	Androgen_receptor	0,17	androgen	Androgen receptor	CHEBI:50113	367	Chemical	Gene	elements|amod|START_ENTITY analysis|nmod|elements signalling|dep|analysis signalling|amod|END_ENTITY	Androgen_receptor signalling : comparative analysis of androgen response elements and implication of heat-shock_protein_90_and_14-3-3eta .
11306464	0	androgen	104,112	Androgen_receptor	0,17	androgen	Androgen receptor	CHEBI:50113	367	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|stabilization stabilization|amod|END_ENTITY	Androgen_receptor stabilization in recurrent prostate_cancer is associated with hypersensitivity to low androgen .
11818512	0	androgen	42,50	Androgen_receptor	0,17	androgen	Androgen receptor	CHEBI:50113	367	Chemical	Gene	insensitivity_syndromes|compound|START_ENTITY causing|dobj|insensitivity_syndromes mutations|acl|causing mutations|amod|END_ENTITY	Androgen_receptor mutations causing human androgen insensitivity_syndromes show a key role of residue M807 in Helix 8-Helix 10 interactions and in receptor ligand-binding_domain stability .
12210844	0	androgen	97,105	Androgen_receptor	0,17	androgen	Androgen receptor	CHEBI:50113	24208(Tax:10116)	Chemical	Gene	action|compound|START_ENTITY site|nmod|action implications|nmod|site RNA|dep|implications RNA|compound|END_ENTITY	Androgen_receptor messenger RNA and protein in adult rat sciatic nerve : implications for site of androgen action .
15472231	0	androgen	97,105	Androgen_receptor	0,17	androgen	Androgen receptor	CHEBI:50113	367	Chemical	Gene	treatment|compound|START_ENTITY up-regulation|nmod|treatment END_ENTITY|dep|up-regulation	Androgen_receptor in human skeletal muscle and cultured muscle satellite cells : up-regulation by androgen treatment .
15982869	0	androgen	94,102	Androgen_receptor	0,17	androgen	Androgen receptor	CHEBI:50113	367	Chemical	Gene	induces|nmod|START_ENTITY induces|nsubj|regulation regulation|amod|END_ENTITY	Androgen_receptor down regulation by small interference RNA induces cell growth inhibition in androgen sensitive as well as in androgen independent prostate_cancer cells .
16645434	0	androgen	46,54	Androgen_receptor	0,17	androgen	Androgen receptor	CHEBI:50113	367	Chemical	Gene	prostate_cancer|amod|START_ENTITY target|nmod|prostate_cancer END_ENTITY|nmod|target	Androgen_receptor as a therapeutic target for androgen independent prostate_cancer .
17728259	0	androgen	61,69	Androgen_receptor	0,17	androgen	Androgen receptor	CHEBI:50113	367	Chemical	Gene	element|amod|START_ENTITY END_ENTITY|nmod|element	Androgen_receptor regulation of the versican gene through an androgen response element in the proximal promoter .
18406699	0	androgen	39,47	Androgen_receptor	0,17	androgen	Androgen receptor	CHEBI:50113	367	Chemical	Gene	insensitivity|compound|START_ENTITY dysfunction|nmod|insensitivity dysfunction|nsubj|END_ENTITY	Androgen_receptor dysfunction in human androgen insensitivity .
20947401	0	androgen	40,48	Androgen_receptor	0,17	androgen	Androgen receptor	CHEBI:50113	367	Chemical	Gene	levels|compound|START_ENTITY relation|nmod|levels htSNPs|nmod|relation htSNPs|amod|END_ENTITY	Androgen_receptor htSNPs in relation to androgen levels and OC use in young women from high-risk breast_cancer families .
22001143	0	androgen	56,64	Androgen_receptor	0,17	androgen	Androgen receptor	CHEBI:50113	367	Chemical	Gene	sensitivity|compound|START_ENTITY marker|nmod|sensitivity marker|nsubj|expression expression|amod|END_ENTITY	Androgen_receptor expression is a biological marker for androgen sensitivity in high grade serous_epithelial_ovarian_cancer .
2210624	0	androgen	63,71	Androgen_receptor	0,17	androgen	Androgen receptor	CHEBI:50113	367	Chemical	Gene	resistance|compound|START_ENTITY patients|nmod|resistance defects|nmod|patients defects|amod|END_ENTITY	Androgen_receptor defects in patients with minimal and partial androgen resistance classified according to a model of androgen-receptor complex energy states .
22334658	0	androgen	41,49	Androgen_receptor	0,17	androgen	Androgen receptor	CHEBI:50113	367	Chemical	Gene	insensitivity|compound|START_ENTITY causes|dobj|insensitivity causes|nsubj|mutation mutation|amod|END_ENTITY	Androgen_receptor exon 1 mutation causes androgen insensitivity by creating phosphorylation site and inhibiting melanoma antigen-A11 activation of NH2 - and carboxyl-terminal interaction-dependent transactivation .
2301571	0	androgen	52,60	Androgen_receptor	0,17	androgen	Androgen receptor	CHEBI:50113	24208(Tax:10116)	Chemical	Gene	down-regulated|nmod|START_ENTITY down-regulated|nsubj|END_ENTITY	Androgen_receptor of rat penis is down-regulated by androgen .
23752196	0	androgen	125,133	Androgen_receptor	0,17	androgen	Androgen receptor	CHEBI:50113	367	Chemical	Gene	targeting|dobj|START_ENTITY agents|acl|targeting resistance|nmod|agents prostate_cancer|nmod|resistance functions|nmod|prostate_cancer functions|amod|END_ENTITY	Androgen_receptor functions in castration-resistant prostate_cancer and mechanisms of resistance to new agents targeting the androgen axis .
8156934	0	androgen	67,75	Androgen_receptor	0,17	androgen	Androgen receptor	CHEBI:50113	24208(Tax:10116)	Chemical	Gene	regulation|compound|START_ENTITY implications|nmod|regulation distribution|dep|implications distribution|amod|END_ENTITY	Androgen_receptor distribution in rat testis : new implications for androgen regulation of spermatogenesis .
8435194	0	androgen	35,43	Androgen_receptor	0,17	androgen	Androgen receptor	CHEBI:50113	367	Chemical	Gene	action|compound|START_ENTITY END_ENTITY|nmod|action	Androgen_receptor and mechanism of androgen action .
9000575	0	androgen	73,81	Androgen_receptor	0,17	androgen	Androgen receptor	CHEBI:50113	367	Chemical	Gene	failure|amod|START_ENTITY mechanism|nmod|failure amplification|dep|mechanism amplification|amod|END_ENTITY	Androgen_receptor gene amplification : a possible molecular mechanism for androgen deprivation therapy failure in prostate_cancer .
9076469	0	androgen	199,207	Androgen_receptor	0,17	androgen	Androgen receptor	CHEBI:50113	367	Chemical	Gene	blockade|compound|START_ENTITY response|nmod|blockade prostate_cancer|nmod|response prostate_cancer|nsubj|amplification amplification|amod|END_ENTITY	Androgen_receptor gene amplification in a recurrent prostate_cancer after monotherapy with the nonsteroidal potent antiandrogen Casodex -LRB- bicalutamide -RRB- with a subsequent favorable response to maximal androgen blockade .
21187157	0	androgen	122,130	Bcl-xL	104,110	androgen	Bcl-xL	CHEBI:50113	598	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Activation of a non-genomic Pim-1 / Bad-Pser75 module is required for an efficient pro-survival effect of Bcl-xL induced by androgen in LNCaP cells .
10999829	0	androgen	44,52	Bone_morphogenetic_protein	0,26	androgen	Bone morphogenetic protein	CHEBI:50113	649	Chemical	Gene	production|compound|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Bone_morphogenetic_protein inhibits ovarian androgen production .
9377562	0	androgen	63,71	CDK2	86,90	androgen	CDK2	CHEBI:50113	1017	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Regulation of androgen-dependent prostatic_cancer cell growth : androgen regulation of CDK2 , CDK4 , and CKI p16 genes .
9763410	0	androgen	10,18	CYP3A	69,74	androgen	CYP3A	CHEBI:50113	170509(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY Effect|nmod|administration Effect|nmod|END_ENTITY	Effect of androgen administration during puberty on hepatic CYP2C11 , CYP3A , and CYP2A1 expression in adult female rats .
22885098	0	androgen	102,110	CYP3A4	81,87	androgen	CYP3A4	CHEBI:50113	1576	Chemical	Gene	elimination|compound|START_ENTITY END_ENTITY|nmod|elimination	Unexpected contribution of cytochrome P450 enzymes CYP11B2 and CYP21 , as well as CYP3A4 in xenobiotic androgen elimination - insights from metandienone metabolism .
10599726	0	androgen	42,50	Corticotropin-releasing_hormone	0,31	androgen	Corticotropin-releasing hormone	CHEBI:50113	1392	Chemical	Gene	secretagogue|compound|START_ENTITY END_ENTITY|dep|secretagogue	Corticotropin-releasing_hormone : a potent androgen secretagogue in girls with hyperandrogenism after precocious_pubarche .
23604126	0	androgen	22,30	DAB2IP	12,18	androgen	DAB2IP	CHEBI:50113	153090	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	The role of DAB2IP in androgen receptor activation during prostate_cancer progression .
26512963	0	androgen	57,65	DAB2IP	0,6	androgen	DAB2IP	CHEBI:50113	69601(Tax:10090)	Chemical	Gene	confers|xcomp|START_ENTITY confers|nsubj|loss loss|compound|END_ENTITY	DAB2IP loss confers the resistance of prostate_cancer to androgen deprivation therapy through activating STAT3 and inhibiting apoptosis .
19888222	0	androgen	52,60	Epidermal_growth_factor_receptor	0,32	androgen	Epidermal growth factor receptor	CHEBI:50113	1956	Chemical	Gene	regulation|compound|START_ENTITY regulation|amod|END_ENTITY	Epidermal_growth_factor_receptor expression escapes androgen regulation in prostate_cancer : a potential molecular switch for tumour growth .
24284406	0	androgen	21,29	Fut1	51,55	androgen	Fut1	CHEBI:50113	14343(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|nmod|END_ENTITY	Different effects of androgen on the expression of Fut1 , Fut2 , Fut4 and Fut9 in male mouse reproductive tract .
9360530	0	androgen	29,37	GH	100,102	androgen	GH	CHEBI:50113	2688	Chemical	Gene	modulation|nmod|START_ENTITY modulation|appos|END_ENTITY	Short-term modulation of the androgen milieu alters pulsatile , but not exercise - or growth_hormone -LRB- GH -RRB- - releasing hormone-stimulated GH secretion in healthy men : impact of gonadal steroid and GH secretory changes on metabolic outcomes .
12063252	0	androgen	45,53	GSK3beta	70,78	androgen	GSK3beta	CHEBI:50113	2932	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|amod|END_ENTITY	Phosphatidylinositol 3-kinase/Akt stimulates androgen pathway through GSK3beta inhibition and nuclear beta-catenin accumulation .
11597543	0	androgen	20,28	GnRH	103,107	androgen	GnRH	CHEBI:50113	2796	Chemical	Gene	suppression|compound|START_ENTITY Effective|dobj|suppression Effective|advcl|using using|nmod|histrelin histrelin|compound|END_ENTITY	Effective long-term androgen suppression in men with prostate_cancer using a hydrogel implant with the GnRH agonist histrelin .
11726576	0	androgen	161,169	GnRH	76,80	androgen	GnRH	CHEBI:50113	2796	Chemical	Gene	maintained|nmod|START_ENTITY maintained|nsubjpass|Suppression Suppression|nmod|spermatogenesis spermatogenesis|nmod|azoospermia azoospermia|nmod|administration administration|nmod|END_ENTITY	Suppression of spermatogenesis to azoospermia by combined administration of GnRH antagonist and 19-nortestosterone can not be maintained by this non-aromatizable androgen alone .
22286802	0	androgen	118,126	GnRH	81,85	androgen	GnRH	CHEBI:50113	2796	Chemical	Gene	status|compound|START_ENTITY regardless|nmod|status stimulation|advmod|regardless stimulation|compound|END_ENTITY	Women with oligo - / amenorrhoea and polycystic_ovaries have identical responses to GnRH stimulation regardless of their androgen status : comparison of the Rotterdam and Androgen Excess Society diagnostic criteria .
26518305	0	androgen	56,64	GnRH	82,86	androgen	GnRH	CHEBI:50113	2796	Chemical	Gene	deprivation|compound|START_ENTITY deprivation|nmod|analogues analogues|compound|END_ENTITY	-LSB- Quality of life of patients with prostate_cancer under androgen deprivation with GnRH analogues : Results of the noninterventional study TRIPTOSIX -RSB- .
26637324	0	androgen	36,44	GnRH	83,87	androgen	GnRH	CHEBI:50113	2796	Chemical	Gene	therapy|amod|START_ENTITY patients|nmod|therapy patients|dep|risk risk|nmod|antagonists antagonists|amod|END_ENTITY	-LSB- Cardiovascular risk patients under androgen deprivation therapy : Lower risk with GnRH antagonists compared to LHRH agonists ? -RSB- .
2934582	0	androgen	101,109	GnRH	20,24	androgen	GnRH	CHEBI:50113	2796	Chemical	Gene	using|dobj|START_ENTITY contraception|acl|using approach|nmod|contraception effects|dep|approach effects|nmod|agonist agonist|compound|END_ENTITY	Hormonal effects of GnRH agonist in the human male : an approach to male contraception using combined androgen and GnRH agonist treatment .
3275542	0	androgen	61,69	GnRH	180,184	androgen	GnRH	CHEBI:50113	2796	Chemical	Gene	production|compound|START_ENTITY production|dep|evidence evidence|nmod|existence existence|nmod|END_ENTITY	A gonadotropin-releasing_hormone -LRB- GnRH -RRB- antagonist decreases androgen production and spermatogonial multiplication in frog -LRB- Rana esculenta -RRB- : indirect evidence for the existence of GnRH or GnRH-like material receptors in the hypophysis and testis .
3275542	0	androgen	61,69	GnRH	34,38	androgen	GnRH	CHEBI:50113	2796	Chemical	Gene	production|compound|START_ENTITY production|appos|END_ENTITY	A gonadotropin-releasing_hormone -LRB- GnRH -RRB- antagonist decreases androgen production and spermatogonial multiplication in frog -LRB- Rana esculenta -RRB- : indirect evidence for the existence of GnRH or GnRH-like material receptors in the hypophysis and testis .
6428973	0	androgen	12,20	GnRH	125,129	androgen	GnRH	CHEBI:50113	2796	Chemical	Gene	role|nmod|START_ENTITY responsiveness|nsubj|role responsiveness|xcomp|gonadotropin_releasing_hormone gonadotropin_releasing_hormone|ccomp|agonist agonist|nsubj|END_ENTITY	The role of androgen in the development of sexual differences in pituitary responsiveness to gonadotropin_releasing_hormone -LRB- GnRH -RRB- agonist in the bullfrog , Rana catesbeiana .
9246946	0	androgen	81,89	GnRH	55,59	androgen	GnRH	CHEBI:50113	2796	Chemical	Gene	index|compound|START_ENTITY Blockade|dep|index Blockade|nmod|increase increase|nmod|testosterone testosterone|nmod|antagonist antagonist|compound|END_ENTITY	Blockade of the neonatal increase in testosterone by a GnRH antagonist : the free androgen index , reproductive capacity and postmortem findings in the male marmoset monkey .
26567252	0	androgen	59,67	Gonadotropin-releasing_hormone	0,30	androgen	Gonadotropin-releasing hormone	CHEBI:50113	2796	Chemical	Gene	therapy|compound|START_ENTITY antagonists|nmod|therapy antagonists|amod|END_ENTITY	Gonadotropin-releasing_hormone antagonists versus standard androgen suppression therapy for advanced_prostate_cancer A systematic review with meta-analysis .
10459853	0	androgen	94,102	Growth_hormone	0,14	androgen	Growth hormone	CHEBI:50113	14599(Tax:10090)	Chemical	Gene	enhance|nmod|START_ENTITY enhance|nsubj|END_ENTITY	Growth_hormone and insulin-like_growth_factor-I enhance beta-glucuronidase gene activation by androgen in mouse kidney .
1360928	0	androgen	39,47	Growth_hormone	0,14	androgen	Growth hormone	CHEBI:50113	81668(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY stimulate|dobj|receptor stimulate|nsubj|END_ENTITY	Growth_hormone and prolactin stimulate androgen receptor , insulin-like_growth_factor-I -LRB- IGF-I -RRB- and IGF-I_receptor levels in the prostate of immature rats .
9302369	0	androgen	75,83	Growth_hormone	0,14	androgen	Growth hormone	CHEBI:50113	2688	Chemical	Gene	effects|compound|START_ENTITY augments|dobj|effects augments|nsubj|substitution substitution|amod|END_ENTITY	Growth_hormone substitution in adult growth_hormone-deficient men augments androgen effects on the skin .
20101233	0	androgen	44,52	Heat_shock_protein_27	0,21	androgen	Heat shock protein 27	CHEBI:50113	3315	Chemical	Gene	confers|advcl|START_ENTITY confers|nsubj|END_ENTITY	Heat_shock_protein_27 confers resistance to androgen ablation and chemotherapy in prostate_cancer cells through eIF4E .
12233876	0	androgen	45,53	IL-1beta	87,95	androgen	IL-1beta	CHEBI:50113	3553	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Androgen receptors in human synoviocytes and androgen regulation of interleukin_1beta -LRB- IL-1beta -RRB- induced IL-6 production : a link between hypoandrogenicity and rheumatoid_arthritis ?
9722934	0	androgen	52,60	IL-6	0,4	androgen	IL-6	CHEBI:50113	3569	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|compound|END_ENTITY	IL-6 expression by oral fibroblasts is regulated by androgen .
19201527	0	androgen	81,89	Id-1	0,4	androgen	Id-1	CHEBI:50113	3397	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	Id-1 expression in androgen-dependent prostate_cancer is negatively regulated by androgen through androgen_receptor .
16434464	0	androgen	36,44	Insulin	0,7	androgen	Insulin	CHEBI:50113	3630	Chemical	Gene	blockade|compound|START_ENTITY sensitivity|nmod|blockade sensitivity|nsubj|END_ENTITY	Insulin sensitivity during combined androgen blockade for prostate_cancer .
16821212	0	androgen	68,76	Insulin	1,8	androgen	Insulin	CHEBI:50113	3630	Chemical	Gene	START_ENTITY|nsubj|resistance resistance|amod|END_ENTITY	-LSB- Insulin resistance and serum concentrations of ovarian and adrenal androgen in obese women without additional disease and with policystic_ovary_syndrome -RSB- .
19550127	0	androgen	99,107	Insulin	0,7	androgen	Insulin	CHEBI:50113	3630	Chemical	Gene	blockade|compound|START_ENTITY undergoing|dobj|blockade resistance|acl|undergoing resistance|compound|END_ENTITY	Insulin resistance in patients with advanced_prostate_cancer undergoing intermittent or continuous androgen blockade .
2146169	0	androgen	42,50	Insulin	0,7	androgen	Insulin	CHEBI:50113	3630	Chemical	Gene	production|compound|START_ENTITY augments|dobj|production augments|nsubj|infusion infusion|compound|END_ENTITY	Insulin infusion acutely augments ovarian androgen production in normal women .
3326891	0	androgen	33,41	Insulin	0,7	androgen	Insulin	CHEBI:50113	3630	Chemical	Gene	production|compound|START_ENTITY factor|nmod|production END_ENTITY|nmod|factor	Insulin as a factor of increased androgen production in women with obesity and polycystic_ovaries .
3514651	0	androgen	19,27	Insulin	0,7	androgen	Insulin	CHEBI:50113	3630	Chemical	Gene	accumulation|compound|START_ENTITY stimulates|dobj|accumulation stimulates|nsubj|END_ENTITY	Insulin stimulates androgen accumulation in incubations of ovarian_stroma obtained from women with hyperandrogenism .
6382082	0	androgen	19,27	Insulin	0,7	androgen	Insulin	CHEBI:50113	3630	Chemical	Gene	accumulation|compound|START_ENTITY stimulates|dobj|accumulation stimulates|nsubj|END_ENTITY	Insulin stimulates androgen accumulation in incubations of human ovarian_stroma and theca .
7149493	0	androgen	35,43	Insulin	0,7	androgen	Insulin	CHEBI:50113	3630	Chemical	Gene	excess|compound|START_ENTITY associated|nmod|excess associated|nsubj|resistance resistance|compound|END_ENTITY	Insulin resistance associated with androgen excess in women with autoantibodies to the insulin_receptor .
8050733	0	androgen	19,27	Insulin	0,7	androgen	Insulin	CHEBI:50113	3630	Chemical	Gene	accumulation|compound|START_ENTITY stimulates|dobj|accumulation stimulates|nsubj|END_ENTITY	Insulin stimulates androgen accumulation in incubations of minced porcine theca .
8408513	0	androgen	85,93	Insulin	0,7	androgen	Insulin	CHEBI:50113	3630	Chemical	Gene	secretion|compound|START_ENTITY augments|dobj|secretion augments|nsubj|END_ENTITY	Insulin hypersecretion together with high luteinizing hormone concentration augments androgen secretion in oral glucose tolerance test in women with polycystic_ovarian_disease .
11410519	0	androgen	22,30	Interleukin-6	0,13	androgen	Interleukin-6	CHEBI:50113	3569	Chemical	Gene	responsiveness|compound|START_ENTITY induces|dobj|responsiveness induces|nsubj|END_ENTITY	Interleukin-6 induces androgen responsiveness in prostate_cancer cells through up-regulation of androgen_receptor expression .
15176047	0	androgen	61,69	Interleukin-6	0,13	androgen	Interleukin-6	CHEBI:50113	3569	Chemical	Gene	deprivation|compound|START_ENTITY induced|nmod|deprivation apoptosis|acl|induced protects|nmod|apoptosis protects|nsubj|END_ENTITY	Interleukin-6 protects LNCaP cells from apoptosis induced by androgen deprivation through the Stat3 pathway .
19638459	0	androgen	24,32	Interleukin-6	0,13	androgen	Interleukin-6	CHEBI:50113	3569	Chemical	Gene	synthesis|compound|START_ENTITY regulates|dobj|synthesis regulates|nsubj|END_ENTITY	Interleukin-6 regulates androgen synthesis in prostate_cancer cells .
26218834	0	androgen	31,39	Interleukin-6	0,13	androgen	Interleukin-6	CHEBI:50113	280826(Tax:9913)	Chemical	Gene	release|compound|START_ENTITY inhibits|dobj|release inhibits|nsubj|END_ENTITY	Interleukin-6 inhibits adrenal androgen release from bovine adrenal zona_reticularis cells by inhibiting the expression of steroidogenic proteins .
2189544	0	androgen	19,27	LHRH	45,49	androgen	LHRH	CHEBI:50113	2796	Chemical	Gene	blockade|compound|START_ENTITY blockade|nmod|END_ENTITY	Effect of combined androgen blockade with an LHRH agonist and flutamide in one severe case of male exhibitionism .
8252407	0	androgen	11,19	LHRH	33,37	androgen	LHRH	CHEBI:50113	2796	Chemical	Gene	receptors|compound|START_ENTITY receptors|nmod|END_ENTITY	Absence of androgen receptors in LHRH immunoreactive neurons .
18988800	0	androgen	20,28	MCM7	0,4	androgen	MCM7	CHEBI:50113	852501(Tax:4932)	Chemical	Gene	receptor|compound|START_ENTITY interacts|nmod|receptor interacts|nsubj|END_ENTITY	MCM7 interacts with androgen receptor .
16888681	0	androgen	40,48	MMP-2	63,68	androgen	MMP-2	CHEBI:50113	4313	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Dual androgen-response elements mediate androgen regulation of MMP-2 expression in prostate_cancer cells .
23503867	0	androgen	87,95	MRP4	32,36	androgen	MRP4	CHEBI:50113	10257	Chemical	Gene	signaling|compound|START_ENTITY associated|nmod|signaling associated|nsubjpass|expression expression|appos|END_ENTITY	Multidrug_resistance_protein_4 -LRB- MRP4 -RRB- expression in prostate_cancer is associated with androgen signaling and decreases with tumor progression .
12213679	0	androgen	60,68	NGFR	87,91	androgen	NGFR	CHEBI:50113	4804	Chemical	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Nerve_growth_factor induces the re-expression of functional androgen receptors and p75 -LRB- NGFR -RRB- in the androgen-insensitive prostate_cancer cell line DU145 .
21980524	0	androgen	37,45	NSSR1	17,22	androgen	NSSR1	CHEBI:50113	14105(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Dephosphorylated NSSR1 is induced by androgen in mouse epididymis and phosphorylated NSSR1 is increased during sperm maturation .
22575506	0	androgen	51,59	Nur77	79,84	androgen	Nur77	CHEBI:50113	3164	Chemical	Gene	START_ENTITY|nmod|suppression suppression|nmod|END_ENTITY	Testicular steroidogenesis is locally regulated by androgen via suppression of Nur77 .
3397935	0	androgen	48,56	Ornithine_decarboxylase	0,23	androgen	Ornithine decarboxylase	CHEBI:50113	24609(Tax:10116)	Chemical	Gene	action|compound|START_ENTITY marker|nmod|action activity|nmod|marker activity|amod|END_ENTITY	Ornithine_decarboxylase activity as a marker of androgen and antiandrogen action in the rat epididymis .
21548940	0	androgen	33,41	PBX3	14,18	androgen	PBX3	CHEBI:50113	5090	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of PBX3 expression by androgen and Let-7d in prostate_cancer .
19932013	0	androgen	27,35	PCB	62,65	androgen	PCB	CHEBI:50113	25104(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|nmod|END_ENTITY	Differential expression of androgen and estrogen receptors in PCB -LRB- Aroclor_1254 -RRB- - exposed rat ventral prostate : impact of alpha-tocopherol .
15129430	0	androgen	91,99	PI3K	37,41	androgen	PI3K	CHEBI:50113	5293	Chemical	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Regulation of interleukin-6-mediated PI3K activation and neuroendocrine differentiation by androgen signaling in prostate_cancer LNCaP cells .
16378119	0	androgen	76,84	PTTG1	66,71	androgen	PTTG1	CHEBI:50113	9232	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	-LSB- Regulation of expression of pituitary_tumor_transforming_gene_1 -LRB- PTTG1 -RRB- by androgen in prostate_cancer -RSB- .
21385902	0	androgen	62,70	PrLZ	0,4	androgen	PrLZ	CHEBI:50113	7163	Chemical	Gene	deprivation|compound|START_ENTITY induced|nmod|deprivation apoptosis|acl|induced protects|nmod|apoptosis protects|nsubj|END_ENTITY	PrLZ protects prostate_cancer cells from apoptosis induced by androgen deprivation via the activation of Stat3/Bcl -2 pathway .
180740	3	androgen	600,608	Prolactin	455,464	androgen	prolactin	CHEBI:50113	5617	Chemical	Gene	synthesis|compound|START_ENTITY stimulating|dobj|synthesis effective|advcl|stimulating stimulated|advcl|effective stimulated|nsubj|END_ENTITY	Prolactin and ACTH stimulated the synthesis of estrogens by the tissue whereas GH , LH and ACTH were more effective than prolactin in stimulating androgen synthesis .
189591	0	androgen	26,34	Prolactin	0,9	androgen	Prolactin	CHEBI:50113	19109(Tax:10090)	Chemical	Gene	action|compound|START_ENTITY influences|nmod|action influences|nsubj|END_ENTITY	Prolactin influences upon androgen action in male accessory sex organs .
2935426	0	androgen	31,39	Prolactin	0,9	androgen	Prolactin	CHEBI:50113	5617	Chemical	Gene	metabolism|compound|START_ENTITY modulates|dobj|metabolism modulates|nsubj|END_ENTITY	Prolactin modulates peripheral androgen metabolism .
2995004	0	androgen	29,37	Prolactin	0,9	androgen	Prolactin	CHEBI:50113	5617	Chemical	Gene	secretion|compound|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Prolactin stimulates adrenal androgen secretion in infant baboons .
6090494	0	androgen	41,49	Prolactin	0,9	androgen	Prolactin	CHEBI:50113	5617	Chemical	Gene	secretion|compound|START_ENTITY effect|nmod|secretion has|dobj|effect has|nsubj|END_ENTITY	Prolactin has a direct effect on adrenal androgen secretion .
17430253	0	androgen	155,163	Prostate-specific_antigen	0,25	androgen	Prostate-specific antigen	CHEBI:50113	354	Chemical	Gene	therapy|compound|START_ENTITY trend|nmod|therapy predictors|nmod|trend half-life|dep|predictors half-life|amod|END_ENTITY	Prostate-specific_antigen half-life and pretreatment prostate-specific_antigen : crucial predictors for prostate-specific_antigen trend in delayed-combined androgen blockade therapy .
22369480	1	androgen	75,83	Prostate-specific_antigen	19,44	androgen	Prostate-specific antigen	CHEBI:50113	354	Chemical	Gene	bicalutamide|compound|START_ENTITY response|nmod|bicalutamide response|amod|END_ENTITY	Prostate-specific_antigen response to deferred combined androgen blockade therapy using bicalutamide predicts survival after subsequent oestrogen and docetaxel therapies in patients with castration-resistant prostate_cancer .
23060997	0	androgen	94,102	Prostate-specific_antigen	0,25	androgen	Prostate-specific antigen	CHEBI:50113	354	Chemical	Gene	blockade|compound|START_ENTITY nadir|nmod|blockade nadir|nmod|nadir nadir|amod|END_ENTITY	Prostate-specific_antigen nadir and time to prostate-specific_antigen nadir following maximal androgen blockade independently predict prognosis in patients with metastatic_prostate_cancer .
23774685	0	androgen	41,49	Prostate-specific_antigen	0,25	androgen	Prostate-specific antigen	CHEBI:50113	354	Chemical	Gene	therapy|amod|START_ENTITY kinetics|nmod|therapy kinetics|nsubj|END_ENTITY	Prostate-specific_antigen kinetics under androgen deprivation therapy and prostate_cancer prognosis .
24092918	0	androgen	75,83	Prostate-specific_antigen	0,25	androgen	Prostate-specific antigen	CHEBI:50113	354	Chemical	Gene	connection|amod|START_ENTITY trials|dep|connection trials|amod|END_ENTITY	Prostate-specific_antigen screening trials and prostate_cancer deaths : the androgen deprivation connection .
25726498	0	androgen	50,58	Prostate-specific_antigen	0,25	androgen	Prostate-specific antigen	CHEBI:50113	354	Chemical	Gene	therapy|compound|START_ENTITY profiles|nmod|therapy profiles|amod|END_ENTITY	Prostate-specific_antigen kinetic profiles during androgen deprivation therapy as prognostic factors in castration-resistant_prostate_cancer .
9062481	0	androgen	69,77	Prostate-specific_antigen	0,25	androgen	Prostate-specific antigen	CHEBI:50113	354	Chemical	Gene	excess|compound|START_ENTITY marker|nmod|excess END_ENTITY|appos|marker	Prostate-specific_antigen in female serum , a potential new marker of androgen excess .
7541862	0	androgen	40,48	Prostate_specific_antigen	0,25	androgen	Prostate specific antigen	CHEBI:50113	354	Chemical	Gene	withdrawal|compound|START_ENTITY END_ENTITY|nmod|withdrawal	Prostate_specific_antigen after gonadal androgen withdrawal and deferred flutamide treatment .
23095933	0	androgen	49,57	RKIP	30,34	androgen	RKIP	CHEBI:50113	23980(Tax:10090)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Transcriptional regulation of RKIP expression by androgen in prostate cells .
8977631	0	androgen	34,42	S100P	14,19	androgen	S100P	CHEBI:50113	6286	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of S100P expression by androgen .
15146368	0	androgen	26,34	SHBG	21,25	androgen	SHBG	CHEBI:50113	6462	Chemical	Gene	sensitivity|compound|START_ENTITY sensitivity|compound|END_ENTITY	Applicability of the SHBG androgen sensitivity test in the differential diagnosis of 46 , XY gonadal_dysgenesis , true hermaphroditism , and androgen_insensitivity_syndrome .
23426182	0	androgen	12,20	SOX9	53,57	androgen	SOX9	CHEBI:50113	6662	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	ERG induces androgen receptor-mediated regulation of SOX9 in prostate_cancer .
18684447	0	androgen	38,46	SULT2A1	79,86	androgen	SULT2A1	CHEBI:50113	6822	Chemical	Gene	production|compound|START_ENTITY Effect|nmod|production Effect|nmod|END_ENTITY	Effect of insulin and testosterone on androgen production and transcription of SULT2A1 in the NCI-H295R adrenocortical cell line .
15172988	0	androgen	35,43	TPD52	58,63	androgen	TPD52	CHEBI:50113	7163	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Overexpression , amplification , and androgen regulation of TPD52 in prostate_cancer .
2249629	0	androgen	51,59	Transforming_growth_factor-beta_1	0,33	androgen	Transforming growth factor-beta 1	CHEBI:50113	59086(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Transforming_growth_factor-beta_1 inhibits ovarian androgen production : gene expression , cellular localization , mechanisms -LRB- s -RRB- , and site -LRB- s -RRB- of action .
15897888	0	androgen	26,34	VEGF-C	16,22	androgen	VEGF-C	CHEBI:50113	7424	Chemical	Gene	depletion|compound|START_ENTITY END_ENTITY|nmod|depletion	Upregulation of VEGF-C by androgen depletion : the involvement of IGF-IR-FOXO pathway .
11176459	0	androgen	157,165	Vascular_endothelial_growth_factor	0,34	androgen	Vascular endothelial growth factor	CHEBI:50113	7422	Chemical	Gene	destabilization|amod|START_ENTITY evidence|nmod|destabilization prostate_carcinoma|dep|evidence androgens|nmod|prostate_carcinoma regulated|nmod|androgens regulated|nsubjpass|expression expression|amod|END_ENTITY	Vascular_endothelial_growth_factor expression and tumor angiogenesis are regulated by androgens in hormone responsive human prostate_carcinoma : evidence for androgen dependent destabilization of vascular_endothelial_growth_factor transcripts .
16384856	0	androgen	87,95	Vav3	0,4	androgen	Vav3	CHEBI:50113	10451	Chemical	Gene	increases|xcomp|START_ENTITY increases|nsubj|END_ENTITY	Vav3 , a Rho GTPase guanine_nucleotide exchange factor , increases during progression to androgen independence in prostate_cancer cells and potentiates androgen_receptor transcriptional activity .
25746209	0	androgen	15,23	aP2	76,79	androgen	aP2	CHEBI:50113	7020	Chemical	Gene	therapy|compound|START_ENTITY effects|nmod|therapy effects|nmod|END_ENTITY	The effects of androgen deprivation therapy with weight management on serum aP2 and adiponectin levels in prostate_cancer patients .
17113911	0	androgen	92,100	adrenomedullin	17,31	androgen	adrenomedullin	CHEBI:50113	25026(Tax:10116)	Chemical	Gene	regulation|compound|START_ENTITY Participation|nmod|regulation Participation|nmod|END_ENTITY	Participation of adrenomedullin and its relation with vascular_endothelial_growth_factor in androgen regulation of prostatic blood flow in vivo .
2296011	0	androgen	35,43	androgen_binding_protein	63,87	androgen	androgen binding protein	CHEBI:50113	24775(Tax:10116)	Chemical	Gene	START_ENTITY|amod|binding binding|nmod|END_ENTITY	A novel , nonsteroidal inhibitor of androgen binding to the rat androgen_binding_protein : diethyl _ -LSB- -LSB- -LSB- 3 - -LRB- 2,6-dimethyl-4-pyridinyl -RRB- -4 - fluorophenyl -RSB- amino -RSB- methylene -RSB- propanedioate .
10318905	0	androgen	104,112	androgen_receptor	32,49	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	genes|amod|START_ENTITY induction|nmod|genes pathway|nmod|induction pathway|nmod|cascade cascade|nmod|END_ENTITY	From HER2/Neu signal cascade to androgen_receptor and its coactivators : a novel pathway by induction of androgen target genes through MAP kinase in prostate_cancer cells .
10334909	0	androgen	75,83	androgen_receptor	37,54	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	agonistic|compound|START_ENTITY determinant|nmod|agonistic Phosphorylation/dephosphorylation|nmod|determinant Phosphorylation/dephosphorylation|nmod|END_ENTITY	Phosphorylation/dephosphorylation of androgen_receptor as a determinant of androgen agonistic or antagonistic activity .
10363963	0	androgen	75,83	androgen_receptor	14,31	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	antagonist|compound|START_ENTITY treated|nmod|antagonist treated|nsubj|Selection Selection|nmod|mutations mutations|compound|END_ENTITY	Selection for androgen_receptor mutations in prostate_cancers treated with androgen antagonist .
10385404	0	androgen	108,116	androgen_receptor	11,28	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	responsiveness|compound|START_ENTITY associated|nmod|responsiveness associated|nsubjpass|up-regulation up-regulation|compound|END_ENTITY	Homologous androgen_receptor up-regulation in osteoblastic cells may be associated with enhanced functional androgen responsiveness .
10385425	0	androgen	84,92	androgen_receptor	47,64	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Differential posttranscriptional regulation of androgen_receptor gene expression by androgen in prostate and breast_cancer cells .
10396030	0	androgen	111,119	androgen_receptor	36,53	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	levels|compound|START_ENTITY decline|nmod|levels associated|nmod|decline associated|nsubjpass|Evidence Evidence|dep|repeat repeat|nmod|gene gene|compound|END_ENTITY	Evidence that the CAG repeat in the androgen_receptor gene is associated with the age-related decline in serum androgen levels in men .
10470409	0	androgen	77,85	androgen_receptor	28,45	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	resistance|compound|START_ENTITY patient|nmod|resistance mutation|nmod|patient mutation|nmod|gene gene|compound|END_ENTITY	A new point mutation of the androgen_receptor gene in a patient with partial androgen resistance and severe oligozoospermia .
10590174	0	androgen	48,56	androgen_receptor	7,24	androgen	androgen receptor	CHEBI:50113	11835(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY regulation|dep|effects regulation|compound|END_ENTITY	Neural androgen_receptor regulation : effects of androgen and antiandrogen .
10852459	0	androgen	43,51	androgen_receptor	121,138	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	sensitivity|compound|START_ENTITY sensitivity|acl|caused caused|nmod|mutation mutation|nmod|domain domain|nmod|gene gene|compound|END_ENTITY	Preserved male fertility despite decreased androgen sensitivity caused by a mutation in the ligand-binding domain of the androgen_receptor gene .
10906039	0	androgen	11,19	androgen_receptor	23,40	androgen	androgen receptor	CHEBI:50113	24208(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effects of androgen on androgen_receptor expression in rat testicular and epididymal cells : a quantitative immunohistochemical study .
10971094	1	androgen	143,151	androgen_receptor	225,242	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	syndrome|compound|START_ENTITY disorder|nsubj|syndrome disorder|acl|caused caused|nmod|function function|nmod|END_ENTITY	The androgen insensitivity syndrome is a disorder caused by deficient function of the androgen_receptor , characterized by varying degrees of undermasculinization in karyotypic males .
10999816	0	androgen	121,129	androgen_receptor	76,93	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	insensitivity|compound|START_ENTITY kindred|nmod|insensitivity function|nmod|kindred function|nsubj|diversity diversity|nmod|END_ENTITY	Phenotypic diversity and testosterone-induced normalization of mutant L712F androgen_receptor function in a kindred with androgen insensitivity .
11248024	0	androgen	50,58	androgen_receptor	97,114	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	signaling|xcomp|START_ENTITY transforming_growth_factor-beta|acl|signaling coregulator|nmod|transforming_growth_factor-beta coregulator|nsubj|identification identification|nmod|Smad3 Smad3|nmod|END_ENTITY	From transforming_growth_factor-beta signaling to androgen action : identification of Smad3 as an androgen_receptor coregulator in prostate_cancer cells .
11260228	0	androgen	79,87	androgen_receptor	31,48	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	insensitivity|compound|START_ENTITY defects|nmod|insensitivity defects|nmod|gene gene|compound|END_ENTITY	Novel molecular defects in the androgen_receptor gene of Mexican patients with androgen insensitivity .
11376111	0	androgen	91,99	androgen_receptor	59,76	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	linked|xcomp|START_ENTITY linked|nsubjpass|interactions interactions|nmod|END_ENTITY	Disrupted amino - and carboxyl-terminal interactions of the androgen_receptor are linked to androgen insensitivity .
11380707	0	androgen	112,120	androgen_receptor	77,94	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	insensitivity_syndrome|compound|START_ENTITY amino_acid|nmod|insensitivity_syndrome amino_acid|nmod|gene gene|compound|END_ENTITY	Novel amino_acid substitutional mutation , tyrosine-739-aspartic_acid , in the androgen_receptor gene in complete androgen insensitivity_syndrome .
11397855	0	androgen	100,108	androgen_receptor	21,38	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	levels|compound|START_ENTITY associated|nmod|levels associated|nsubjpass|Polymorphisms Polymorphisms|nmod|gene gene|compound|END_ENTITY	Polymorphisms of the androgen_receptor gene and the estrogen receptor beta gene are associated with androgen levels in women .
11410519	0	androgen	22,30	androgen_receptor	96,113	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	responsiveness|compound|START_ENTITY induces|dobj|responsiveness induces|nmod|up-regulation up-regulation|nmod|expression expression|compound|END_ENTITY	Interleukin-6 induces androgen responsiveness in prostate_cancer cells through up-regulation of androgen_receptor expression .
11606392	0	androgen	83,91	androgen_receptor	14,31	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	independence|compound|START_ENTITY responsible|nmod|independence responsible|nsubj|END_ENTITY	Overexpressed androgen_receptor linked to p21WAF1 silencing may be responsible for androgen independence and resistance to apoptosis of a prostate_cancer cell line .
11673900	0	androgen	18,26	androgen_receptor	115,132	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	assay|amod|START_ENTITY Development|nmod|assay Development|acl|utilizing utilizing|nmod|END_ENTITY	Development of an androgen reporter gene assay -LRB- AR-LUX -RRB- utilizing a human cell line with an endogenously regulated androgen_receptor .
12114445	0	androgen	73,81	androgen_receptor	30,47	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Synergistic activation of the androgen_receptor by bombesin and low-dose androgen .
12370412	0	androgen	109,117	androgen_receptor	35,52	androgen	androgen receptor	CHEBI:50113	11835(Tax:10090)	Chemical	Gene	functions|compound|START_ENTITY study|nmod|functions model|nmod|study Generation|dep|model Generation|nmod|mice mice|amod|knockout knockout|amod|END_ENTITY	Generation and characterization of androgen_receptor knockout -LRB- ARKO -RRB- mice : an in vivo model for the study of androgen functions in selective tissues .
12634308	0	androgen	103,111	androgen_receptor	26,43	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	ablation|compound|START_ENTITY obtained|nmod|ablation obtained|nsubj|analysis analysis|nmod|END_ENTITY	Molecular analysis of the androgen_receptor in ten prostate_cancer specimens obtained before and after androgen ablation .
12637588	0	androgen	47,55	androgen_receptor	69,86	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	responses|compound|START_ENTITY modulation|nmod|responses modulation|nmod|ligands ligands|compound|END_ENTITY	Selective modulation of genomic and nongenomic androgen responses by androgen_receptor ligands .
12727974	0	androgen	156,164	androgen_receptor	11,28	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	insensitivity|compound|START_ENTITY degrees|nmod|insensitivity investigate|nmod|degrees assays|xcomp|investigate assays|nsubj|use use|nmod|interaction interaction|amod|END_ENTITY	The use of androgen_receptor amino/carboxyl-terminal interaction assays to investigate androgen_receptor gene mutations in subjects with varying degrees of androgen insensitivity .
12727974	0	androgen	156,164	androgen_receptor	87,104	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	insensitivity|compound|START_ENTITY degrees|nmod|insensitivity investigate|nmod|degrees investigate|dobj|mutations mutations|compound|END_ENTITY	The use of androgen_receptor amino/carboxyl-terminal interaction assays to investigate androgen_receptor gene mutations in subjects with varying degrees of androgen insensitivity .
12908100	0	androgen	8,16	androgen_receptor	99,116	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	resistance|compound|START_ENTITY resistance|nmod|gene gene|compound|END_ENTITY	Extreme androgen resistance in a kindred with a novel insertion/deletion mutation in exon 5 of the androgen_receptor gene .
1316540	0	androgen	132,140	androgen_receptor	64,81	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	resistance|compound|START_ENTITY cause|nmod|resistance cause|nsubj|substitutions substitutions|nmod|domain domain|nmod|END_ENTITY	Amino_acid substitutions in the DNA-binding domain of the human androgen_receptor are a frequent cause of receptor-binding positive androgen resistance .
1347772	0	androgen	89,97	androgen_receptor	25,42	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	syndrome|compound|START_ENTITY phenotype|nmod|syndrome definition|nmod|phenotype deletion|dep|definition deletion|nmod|gene gene|compound|END_ENTITY	Complete deletion of the androgen_receptor gene : definition of the null phenotype of the androgen insensitivity syndrome and determination of carrier status .
1425449	0	androgen	35,43	androgen_receptor	14,31	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of androgen_receptor by androgen and epidermal_growth_factor in a human prostatic_cancer cell line , LNCaP .
1464650	0	androgen	61,69	androgen_receptor	15,32	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	resistance|compound|START_ENTITY subjects|nmod|resistance Immunoreactive|nmod|subjects Immunoreactive|dobj|expression expression|compound|END_ENTITY	Immunoreactive androgen_receptor expression in subjects with androgen resistance .
1480178	0	androgen	75,83	androgen_receptor	35,52	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	detection|compound|START_ENTITY causing|dobj|detection gene|acl|causing gene|compound|END_ENTITY	Single base mutations in the human androgen_receptor gene causing complete androgen insensitivity : rapid detection by a modified denaturing gradient gel electrophoresis technique .
15037741	0	androgen	59,67	androgen_receptor	20,37	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	elements|compound|START_ENTITY binding|nmod|elements basis|amod|binding basis|nmod|END_ENTITY	Structural basis of androgen_receptor binding to selective androgen response elements .
15056870	0	androgen	127,135	androgen_receptor	47,64	androgen	androgen receptor	CHEBI:50113	24208(Tax:10116)	Chemical	Gene	antagonists|compound|START_ENTITY impaired|nmod|antagonists activity|acl:relcl|impaired exert|dobj|activity essential|xcomp|exert essential|nmod|END_ENTITY	Co-localization with DJ-1 is essential for the androgen_receptor to exert its transcription activity that has been impaired by androgen antagonists .
15118070	0	androgen	103,111	androgen_receptor	65,82	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	phenotypes|compound|START_ENTITY mutations|nmod|phenotypes mutations|nmod|855 855|nmod|result result|compound|END_ENTITY	An examination of how different mutations at arginine 855 of the androgen_receptor result in different androgen insensitivity phenotypes .
15133039	0	androgen	21,29	androgen_receptor	175,192	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	element|amod|START_ENTITY Identification|nmod|element Identification|acl|allowing allowing|nmod|END_ENTITY	Identification of an androgen response element in intron 8 of the sterol_regulatory_element-binding_protein_cleavage-activating_protein gene allowing direct regulation by the androgen_receptor .
15378487	0	androgen	65,73	androgen_receptor	4,21	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	withdrawal|compound|START_ENTITY up-regulated|nmod|withdrawal up-regulated|nsubjpass|CBP CBP|compound|END_ENTITY	The androgen_receptor co-activator CBP is up-regulated following androgen withdrawal and is highly expressed in advanced prostate_cancer .
15389799	0	androgen	85,93	androgen_receptor	64,81	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	action|compound|START_ENTITY END_ENTITY|nmod|action	Effect of GGC -LRB- glycine -RRB- repeat length polymorphism in the human androgen_receptor on androgen action .
15466214	0	androgen	97,105	androgen_receptor	11,28	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	independence|compound|START_ENTITY correlate|nmod|independence correlate|nsubj|Changes Changes|nmod|signaling signaling|amod|END_ENTITY	Changes in androgen_receptor nongenotropic signaling correlate with transition of LNCaP cells to androgen independence .
15486055	0	androgen	96,104	androgen_receptor	31,48	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	insensitivity|compound|START_ENTITY individual|nmod|insensitivity analysis|nmod|individual analysis|nmod|mutation mutation|compound|END_ENTITY	Functional analysis of a novel androgen_receptor mutation , Q902K , in an individual with partial androgen insensitivity .
15486991	0	androgen	30,38	androgen_receptor	57,74	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	activation|compound|START_ENTITY Induction|nmod|activation Induction|nmod|END_ENTITY	Induction of AP-1 activity by androgen activation of the androgen_receptor in LNCaP human prostate_carcinoma cells .
15564783	0	androgen	60,68	androgen_receptor	28,45	androgen	androgen receptor	CHEBI:50113	24208(Tax:10116)	Chemical	Gene	up-regulation|nmod|START_ENTITY up-regulation|nmod|expression expression|compound|END_ENTITY	Homologous up-regulation of androgen_receptor expression by androgen in vascular smooth muscle cells .
15781394	0	androgen	37,45	androgen_receptor	131,148	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|dep|discovery discovery|nmod|ligands ligands|amod|4-substituted_pyrrole-2-carboxamides 4-substituted_pyrrole-2-carboxamides|nmod|scaffold scaffold|nmod|END_ENTITY	Novel non-steroidal/non-anilide type androgen antagonists : discovery of 4-substituted_pyrrole-2-carboxamides as a new scaffold for androgen_receptor ligands .
15809670	0	androgen	111,119	androgen_receptor	29,46	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	therapy|compound|START_ENTITY CAG|nmod|therapy CAG|nsubj|relationship relationship|nmod|END_ENTITY	The relationship between the androgen_receptor CAG repeat polymorphism length and the response to intermittent androgen suppression therapy for advanced prostate_cancer .
15833875	0	androgen	76,84	androgen_receptor	39,56	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	responsive|amod|START_ENTITY enhancer|amod|responsive impairs|nmod|enhancer impairs|dobj|recruitment recruitment|compound|END_ENTITY	Inhibition of HER-2 / neu kinase impairs androgen_receptor recruitment to the androgen responsive enhancer .
1588132	0	androgen	51,59	androgen_receptor	25,42	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	resistance|compound|START_ENTITY causing|dobj|resistance defects|acl|causing defects|nmod|END_ENTITY	Molecular defects in the androgen_receptor causing androgen resistance .
15956332	0	androgen	114,122	androgen_receptor	81,98	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	binding|compound|START_ENTITY modulation|nmod|binding communication|dep|modulation communication|nmod|END_ENTITY	Intra-domain communication between the N-terminal and DNA-binding domains of the androgen_receptor : modulation of androgen response element DNA binding .
15958518	0	androgen	83,91	androgen_receptor	32,49	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Indole-3-carbinol inhibition of androgen_receptor expression and downregulation of androgen responsiveness in human prostate_cancer cells .
16015608	0	androgen	78,86	androgen_receptor	8,25	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	independence|compound|START_ENTITY Role|nmod|independence Role|nmod|END_ENTITY	Role of androgen_receptor in the progression of human prostate_tumor cells to androgen independence and insensitivity .
16373394	0	androgen	125,133	androgen_receptor	84,101	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	actions|compound|START_ENTITY highlight|nmod|actions highlight|dobj|importance importance|nmod|interaction interaction|nmod|H3 H3|compound|END_ENTITY	Glutamic_acid 709 substitutions highlight the importance of the interaction between androgen_receptor helices H3 and H12 for androgen and antiandrogen actions .
16598378	0	androgen	19,27	androgen_receptor	158,175	androgen	androgen receptor	CHEBI:50113	11835(Tax:10090)	Chemical	Gene	activation|compound|START_ENTITY impact|nmod|activation impact|dep|study study|nmod|model model|compound|END_ENTITY	Relative impact of androgen and estrogen receptor activation in the effects of androgens on trabecular and cortical bone in growing male mice : a study in the androgen_receptor knockout mouse model .
16805131	0	androgen	92,100	androgen_receptor	21,38	androgen	androgen receptor	CHEBI:50113	24208(Tax:10116)	Chemical	Gene	withdrawal|compound|START_ENTITY testis|dobj|withdrawal testis|nsubj|Loss Loss|nmod|expression expression|compound|END_ENTITY	Loss and recovery of androgen_receptor protein expression in the adult rat testis following androgen withdrawal by ethane_dimethanesulfonate .
16870607	0	androgen	117,125	androgen_receptor	19,36	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	cells|amod|START_ENTITY antiandrogens|nmod|cells activation|nmod|antiandrogens activation|nsubjpass|activity activity|compound|END_ENTITY	Ligand-independent androgen_receptor activity is activation function-2-independent and resistant to antiandrogens in androgen refractory_prostate_cancer cells .
16951154	0	androgen	70,78	androgen_receptor	100,117	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	regulated|nmod|START_ENTITY kinase|acl|regulated Male_germ_cell-associated_kinase|appos|kinase coactivator|nsubj|Male_germ_cell-associated_kinase coactivator|nmod|END_ENTITY	Male_germ_cell-associated_kinase , a male-specific kinase regulated by androgen , is a coactivator of androgen_receptor in prostate_cancer cells .
170153	0	androgen	86,94	androgen_receptor	110,127	androgen	androgen receptor	CHEBI:50113	24208(Tax:10116)	Chemical	Gene	START_ENTITY|amod|similar similar|nmod|END_ENTITY	Androgen-binding proteins in rat epididymis : properties of a cytoplasmic receptor for androgen similar to the androgen_receptor in ventral prostate and different from androgen-binding_protein -LRB- ABP -RRB- .
17018919	0	androgen	10,18	androgen_receptor	112,129	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	-LSB-|dobj|START_ENTITY -LSB-|nmod|family family|acl|caused caused|nmod|region region|nmod|END_ENTITY	-LSB- Complete androgen insensitivity in an Icelandic family caused by mutation in the steroid binding region of the androgen_receptor . -RSB-
17073757	0	androgen	52,60	androgen_receptor	4,21	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	selectivity|compound|START_ENTITY determines|dobj|selectivity determines|nsubj|domain domain|compound|END_ENTITY	The androgen_receptor DNA-binding domain determines androgen selectivity of transcriptional response .
17077943	0	androgen	35,43	androgen_receptor	89,106	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	syndrome|amod|START_ENTITY density|nmod|syndrome density|nmod|mutations mutations|nmod|gene gene|compound|END_ENTITY	Height and bone mineral density in androgen insensitivity syndrome with mutations in the androgen_receptor gene .
17202144	0	androgen	57,65	androgen_receptor	118,135	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	START_ENTITY|acl|signaling signaling|nmod|interactions interactions|nmod|Foxo1 Foxo1|nmod|END_ENTITY	Insulin-like_growth_factor_1 / insulin signaling activates androgen signaling through direct interactions of Foxo1 with androgen_receptor .
17360365	0	androgen	47,55	androgen_receptor	8,25	androgen	androgen receptor	CHEBI:50113	11835(Tax:10090)	Chemical	Gene	binding|nmod|START_ENTITY elements|amod|binding elements|compound|END_ENTITY	Loss of androgen_receptor binding to selective androgen response elements causes a reproductive phenotype in a knockin mouse model .
17364555	0	androgen	31,39	androgen_receptor	75,92	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	sensitivity|compound|START_ENTITY increase|dobj|sensitivity increase|nmod|increase increase|nmod|END_ENTITY	Prostate_cancer cells increase androgen sensitivity by increase in nuclear androgen_receptor and androgen_receptor coactivators ; a possible mechanism of hormone-resistance of prostate_cancer cells .
17522416	0	androgen	69,77	androgen_receptor	18,35	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	loss|nmod|START_ENTITY results|nmod|loss results|compound|END_ENTITY	L859F mutation in androgen_receptor gene results in complete loss of androgen binding to the receptor .
17541959	0	androgen	12,20	androgen_receptor	70,87	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	START_ENTITY|acl|determining determining|dobj|differentiation differentiation|nmod|expression expression|compound|END_ENTITY	The role of androgen in determining differentiation and regulation of androgen_receptor expression in the human prostatic epithelium transient amplifying population .
17579205	0	androgen	106,114	androgen_receptor	171,188	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	sensitivity|amod|START_ENTITY reflects|nmod|sensitivity reflects|parataxis|contribution contribution|nmod|polymorphism polymorphism|compound|END_ENTITY	Part of the interindividual variation in serum testosterone levels in healthy men reflects differences in androgen sensitivity and feedback set point : contribution of the androgen_receptor polyglutamine tract polymorphism .
17909000	0	androgen	76,84	androgen_receptor	30,47	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	independence|compound|START_ENTITY mechanism|nmod|independence cleavage|nmod|mechanism cleavage|nsubj|Evidence Evidence|nmod|END_ENTITY	Evidence for calpain-mediated androgen_receptor cleavage as a mechanism for androgen independence .
17942941	0	androgen	91,99	androgen_receptor	59,76	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	cells|amod|START_ENTITY activation|nmod|cells activation|compound|END_ENTITY	Selective role of an NH2-terminal WxxLF motif for aberrant androgen_receptor activation in androgen depletion independent prostate_cancer cells .
17984247	0	androgen	71,79	androgen_receptor	126,143	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	excess|compound|START_ENTITY girls|nmod|excess Flutamide_metformin|nmod|girls Flutamide_metformin|dep|evidence evidence|nmod|response response|nmod|genotype genotype|compound|END_ENTITY	Flutamide_metformin for post-menarcheal girls with preclinical ovarian androgen excess : evidence for differential response by androgen_receptor genotype .
1824495	0	androgen	84,92	androgen_receptor	15,32	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	-RSB-|compound|START_ENTITY Expression|nmod|-RSB- Expression|nmod|gene gene|compound|END_ENTITY	-LSB- Expression of androgen_receptor gene in normal subjects and patients with complete androgen insensitivity -RSB- .
18535355	0	androgen	85,93	androgen_receptor	37,54	androgen	androgen receptor	CHEBI:50113	24208(Tax:10116)	Chemical	Gene	equivalent|xcomp|START_ENTITY equivalent|nsubj|Changes Changes|nmod|expression expression|nmod|blockade blockade|compound|END_ENTITY	Changes in gene expression following androgen_receptor blockade is not equivalent to androgen ablation by castration in the rat ventral prostate .
18571420	0	androgen	72,80	androgen_receptor	162,179	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	antagonists|compound|START_ENTITY effective|dep|antagonists effective|nmod|cells cells|nmod|END_ENTITY	4 - -LRB- Anilino -RRB- pyrrole-2-carboxamides : Novel non-steroidal/non-anilide type androgen antagonists effective upon human prostate_tumor LNCaP cells with mutated nuclear androgen_receptor .
18595795	0	androgen	57,65	androgen_receptor	13,30	androgen	androgen receptor	CHEBI:50113	11835(Tax:10090)	Chemical	Gene	action|amod|START_ENTITY lack|nmod|action reveals|dobj|lack reveals|nsubj|Targeting Targeting|nmod|END_ENTITY	Targeting of androgen_receptor in bone reveals a lack of androgen anabolic action and inhibition of osteogenesis : a model for compartment-specific androgen action in the skeleton .
18713818	0	androgen	14,22	androgen_receptor	124,141	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	insensitivity|compound|START_ENTITY explained|nsubjpass|insensitivity explained|nmod|ontogeny ontogeny|nmod|expression expression|compound|END_ENTITY	Physiological androgen insensitivity of the fetal , neonatal , and early infantile testis is explained by the ontogeny of the androgen_receptor expression in Sertoli cells .
18819937	0	androgen	56,64	androgen_receptor	146,163	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	2,2-bis -LRB- 4-chlorophenyl -RRB- -1,1 - dichloroethylene stimulates androgen independence in prostate_cancer cells through combinatorial activation of mutant androgen_receptor and mitogen-activated protein kinase pathways .
18840639	0	androgen	41,49	androgen_receptor	83,100	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	action|compound|START_ENTITY estrogen|nmod|action associated|nsubjpass|estrogen associated|nmod|repeats repeats|compound|END_ENTITY	Increased estrogen rather than decreased androgen action is associated with longer androgen_receptor CAG repeats .
19062009	0	androgen	94,102	androgen_receptor	24,41	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	affecting|dobj|START_ENTITY disrupts|advcl|affecting disrupts|nsubj|mutation mutation|nmod|END_ENTITY	Ala_586_Asp mutation in androgen_receptor disrupts transactivation function without affecting androgen binding .
19087565	0	androgen	55,63	androgen_receptor	16,33	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	insensitivity|compound|START_ENTITY causes|dobj|insensitivity causes|nsubj|Replacement Replacement|nmod|gene gene|compound|END_ENTITY	-LSB- Replacement of androgen_receptor gene causes complete androgen insensitivity in a large family -RSB- .
19168445	0	androgen	10,18	androgen_receptor	45,62	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	suppression|compound|START_ENTITY Effect|nmod|suppression compared|nsubj|Effect compared|nmod|blockade blockade|compound|END_ENTITY	Effect of androgen suppression compared with androgen_receptor blockade on arterial stiffness in men with prostate_cancer .
19201527	0	androgen	81,89	androgen_receptor	98,115	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nmod|END_ENTITY	Id-1 expression in androgen-dependent prostate_cancer is negatively regulated by androgen through androgen_receptor .
1995608	0	androgen	15,23	androgen_receptor	81,98	androgen	androgen receptor	CHEBI:50113	24208(Tax:10116)	Chemical	Gene	elements|amod|START_ENTITY elements|nmod|domain domain|nmod|END_ENTITY	Interaction of androgen response elements with the DNA-binding domain of the rat androgen_receptor expressed in Escherichia_coli .
1999491	0	androgen	143,151	androgen_receptor	44,61	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	resistance|compound|START_ENTITY patient|nmod|resistance feminization|nmod|patient causes|dobj|feminization causes|nsubj|mutation mutation|nmod|domain domain|nmod|gene gene|compound|END_ENTITY	A mutation in the DNA-binding domain of the androgen_receptor gene causes complete testicular feminization in a patient with receptor-positive androgen resistance .
20069563	0	androgen	28,36	androgen_receptor	75,92	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	transduction|amod|START_ENTITY attenuates|dobj|transduction attenuates|advcl|promoting promoting|dobj|degradation degradation|compound|END_ENTITY	Trihydrophobin_1 attenuates androgen signal transduction through promoting androgen_receptor degradation .
2010552	0	androgen	19,27	androgen_receptor	89,106	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	resistance|compound|START_ENTITY basis|nmod|resistance basis|nmod|family family|nmod|abnormality abnormality|nmod|END_ENTITY	Molecular basis of androgen resistance in a family with a qualitative abnormality of the androgen_receptor and responsive to high-dose androgen therapy .
20231167	0	androgen	24,32	androgen_receptor	87,104	androgen	androgen receptor	CHEBI:50113	11835(Tax:10090)	Chemical	Gene	actions|compound|START_ENTITY actions|nmod|function function|nmod|models models|compound|END_ENTITY	Molecular insights into androgen actions in male and female reproductive function from androgen_receptor knockout models .
2041777	0	androgen	69,77	androgen_receptor	30,47	androgen	androgen receptor	CHEBI:50113	11835(Tax:10090)	Chemical	Gene	insensitivity|compound|START_ENTITY causes|dobj|insensitivity causes|nsubj|mutation mutation|nmod|gene gene|compound|END_ENTITY	A frame-shift mutation in the androgen_receptor gene causes complete androgen insensitivity in the testicular-feminized mouse .
20421209	0	androgen	106,114	androgen_receptor	38,55	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	element|compound|START_ENTITY identification|nmod|element Inhibition|dep|identification Inhibition|nmod|expression expression|nmod|END_ENTITY	Inhibition of cyclin_D1 expression by androgen_receptor in breast_cancer cells -- identification of a novel androgen response element .
20493947	0	androgen	67,75	androgen_receptor	22,39	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	function|compound|START_ENTITY loss|nmod|function results|nmod|loss results|nsubj|mutation mutation|nmod|END_ENTITY	C601S mutation in the androgen_receptor results in partial loss of androgen function .
20671138	0	androgen	68,76	androgen_receptor	22,39	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	function|compound|START_ENTITY loss|nmod|function results|nmod|loss results|nsubj|mutation mutation|nmod|END_ENTITY	G708E mutation in the androgen_receptor results in complete loss of androgen function .
20717902	0	androgen	19,27	androgen_receptor	81,98	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	sensitivity|compound|START_ENTITY reduce|dobj|sensitivity reduce|advcl|decreasing decreasing|dobj|protein protein|compound|END_ENTITY	Statins reduce the androgen sensitivity and cell proliferation by decreasing the androgen_receptor protein in prostate_cancer cells .
21047772	0	androgen	116,124	androgen_receptor	15,32	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	genes|compound|START_ENTITY inhibiting|nmod|genes signaling|advcl|inhibiting END_ENTITY|acl|signaling	HOXC8 inhibits androgen_receptor signaling in human prostate_cancer cells by inhibiting SRC-3 recruitment to direct androgen target genes .
21056661	0	androgen	108,116	androgen_receptor	45,62	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	environment|compound|START_ENTITY hypoxia-inducible_factor-1a|nmod|environment enhances|nmod|hypoxia-inducible_factor-1a enhances|dobj|activity activity|nmod|END_ENTITY	Hypoxia enhances transcriptional activity of androgen_receptor through hypoxia-inducible_factor-1a in a low androgen environment .
21322031	0	androgen	30,38	androgen_receptor	105,122	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	communication|nmod|START_ENTITY communication|dep|perturbations perturbations|nmod|domain domain|amod|END_ENTITY	Dynamic communication between androgen and coactivator : mutually induced conformational perturbations in androgen_receptor ligand-binding domain .
21364123	0	androgen	85,93	androgen_receptor	28,45	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	requirement|compound|START_ENTITY transition|nmod|requirement stability|nmod|transition stability|compound|END_ENTITY	The significance of Her2 on androgen_receptor protein stability in the transition of androgen requirement in prostate_cancer cells .
21410629	0	androgen	122,130	androgen_receptor	34,51	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	therapy|amod|START_ENTITY treated|nmod|therapy treated|nsubj|length length|nmod|END_ENTITY	Germline CAG repeat length of the androgen_receptor and time_to_progression in patients with prostate_cancer treated with androgen deprivation therapy .
21645389	0	androgen	24,32	androgen_receptor	89,106	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	forms|nmod|START_ENTITY insensitivity_syndrome|nsubj|forms insensitivity_syndrome|xcomp|due due|nmod|mutation mutation|nmod|gene gene|compound|END_ENTITY	Severe forms of partial androgen insensitivity_syndrome due to p.L830F novel mutation in androgen_receptor gene in a Brazilian family .
21664242	0	androgen	65,73	androgen_receptor	20,37	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	sensitivity|compound|START_ENTITY determines|dobj|sensitivity determines|nsubj|Length Length|nmod|tract tract|compound|END_ENTITY	Length of the human androgen_receptor glutamine tract determines androgen sensitivity in vivo .
21872641	0	androgen	25,33	androgen_receptor	60,77	androgen	androgen receptor	CHEBI:50113	11835(Tax:10090)	Chemical	Gene	actions|compound|START_ENTITY role|nmod|actions role|nmod|absence absence|nmod|activity activity|compound|END_ENTITY	A physiological role for androgen actions in the absence of androgen_receptor DNA binding activity .
22179832	0	androgen	64,72	androgen_receptor	120,137	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	independence|compound|START_ENTITY promotes|dobj|independence promotes|advcl|increasing increasing|dobj|activation activation|compound|END_ENTITY	Reducing prohibitin increases histone acetylation , and promotes androgen independence in prostate_tumours by increasing androgen_receptor activation by adrenal androgens .
22184375	0	androgen	97,105	androgen_receptor	28,45	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	targeting|dobj|START_ENTITY therapeutics|acl|targeting framework|nmod|therapeutics states|dep|framework states|dep|activation activation|compound|END_ENTITY	Molecular states underlying androgen_receptor activation : a framework for therapeutics targeting androgen signaling in prostate_cancer .
2236003	0	androgen	119,127	androgen_receptor	21,38	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	insensitivity|compound|START_ENTITY patient|nmod|insensitivity protein|nmod|patient splicing|nmod|protein splicing|nmod|results results|compound|END_ENTITY	Aberrant splicing of androgen_receptor mRNA results in synthesis of a nonfunctional receptor protein in a patient with androgen insensitivity .
22389648	0	androgen	74,82	androgen_receptor	12,29	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	targeting|dobj|START_ENTITY approaches|acl|targeting END_ENTITY|dep|approaches	Outsmarting androgen_receptor : creative approaches for targeting aberrant androgen signaling in advanced prostate_cancer .
22396319	0	androgen	97,105	androgen_receptor	28,45	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	therapy|compound|START_ENTITY rationale|nmod|therapy provides|dobj|rationale provides|nsubj|auto-regulation auto-regulation|nmod|END_ENTITY	Adaptive auto-regulation of androgen_receptor provides a paradigm shifting rationale for bipolar androgen therapy -LRB- BAT -RRB- for castrate resistant human prostate_cancer .
22665497	0	androgen	44,52	androgen_receptor	78,95	androgen	androgen receptor	CHEBI:50113	11835(Tax:10090)	Chemical	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	The stress response mediator ATF3 represses androgen signaling by binding the androgen_receptor .
2274054	0	androgen	90,98	androgen_receptor	36,53	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	action|compound|START_ENTITY basis|nmod|action regulation|nsubj|basis confirm|ccomp|regulation confirm|nsubj|characterizations characterizations|nmod|END_ENTITY	Functional characterizations of the androgen_receptor confirm that the molecular basis of androgen action is transcriptional regulation .
2293020	0	androgen	108,116	androgen_receptor	24,41	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	resistance|compound|START_ENTITY cause|dobj|resistance mutations|acl:relcl|cause identification|nmod|mutations permits|dobj|identification permits|nsubj|Definition Definition|nmod|structure structure|compound|END_ENTITY	Definition of the human androgen_receptor gene structure permits the identification of mutations that cause androgen resistance : premature termination of the receptor protein at amino_acid residue 588 causes complete androgen resistance .
2293020	0	androgen	217,225	androgen_receptor	24,41	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	resistance|compound|START_ENTITY protein|nmod|resistance termination|nmod|protein resistance|dep|termination cause|dobj|resistance mutations|acl:relcl|cause identification|nmod|mutations permits|dobj|identification permits|nsubj|Definition Definition|nmod|structure structure|compound|END_ENTITY	Definition of the human androgen_receptor gene structure permits the identification of mutations that cause androgen resistance : premature termination of the receptor protein at amino_acid residue 588 causes complete androgen resistance .
23041906	0	androgen	10,18	androgen_receptor	58,75	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	deprivation|compound|START_ENTITY leads|nsubj|deprivation leads|xcomp|downregulation downregulation|nmod|END_ENTITY	Prolonged androgen deprivation leads to downregulation of androgen_receptor and prostate-specific_membrane_antigen in prostate_cancer cells .
2332504	0	androgen	142,150	androgen_receptor	83,100	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	resistance|compound|START_ENTITY patient|nmod|resistance gene|nmod|patient gene|compound|END_ENTITY	A single nucleotide substitution introduces a premature termination codon into the androgen_receptor gene of a patient with receptor-negative androgen resistance .
2333898	0	androgen	96,104	androgen_receptor	40,57	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	insensitivity|compound|START_ENTITY kindred|nmod|insensitivity gene|nmod|kindred gene|compound|END_ENTITY	DNA linkage analysis and studies of the androgen_receptor gene in a large kindred with complete androgen insensitivity .
2341409	0	androgen	60,68	androgen_receptor	30,47	androgen	androgen receptor	CHEBI:50113	24208(Tax:10116)	Chemical	Gene	insensitivity|compound|START_ENTITY causes|dobj|insensitivity causes|nsubj|mutation mutation|nmod|gene gene|compound|END_ENTITY	A single base mutation in the androgen_receptor gene causes androgen insensitivity in the testicular feminized rat .
23476140	0	androgen	136,144	androgen_receptor	14,31	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	insensitive|compound|START_ENTITY suppressing|nmod|insensitive enhances|advcl|suppressing enhances|nsubj|Inhibition Inhibition|nmod|expression expression|compound|END_ENTITY	Inhibition of androgen_receptor expression with small interfering RNA enhances cancer cell apoptosis by suppressing survival factors in androgen insensitive , late stage LNCaP cells .
24055831	0	androgen	115,123	androgen_receptor	22,39	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	function|compound|START_ENTITY loss|nmod|function causes|nmod|loss causes|nsubj|mutation mutation|nmod|gene gene|compound|END_ENTITY	L712V mutation in the androgen_receptor gene causes complete androgen_insensitivity_syndrome due to severe loss of androgen function .
24449822	0	androgen	56,64	androgen_receptor	19,36	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	deprivation|compound|START_ENTITY variants|nmod|deprivation variants|nsubj|induction induction|nmod|splice splice|compound|END_ENTITY	Rapid induction of androgen_receptor splice variants by androgen deprivation in prostate_cancer .
24671706	0	androgen	90,98	androgen_receptor	42,59	androgen	androgen receptor	CHEBI:50113	11835(Tax:10090)	Chemical	Gene	target|compound|START_ENTITY reveals|nmod|target reveals|nsubj|knockout knockout|nmod|END_ENTITY	A satellite cell-specific knockout of the androgen_receptor reveals myostatin as a direct androgen target in skeletal muscle .
24867960	0	androgen	7,15	androgen_receptor	80,97	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	deprivation|compound|START_ENTITY strategies|nmod|deprivation strategies|acl|targeting targeting|dobj|addiction addiction|compound|END_ENTITY	Beyond androgen deprivation : ancillary integrative strategies for targeting the androgen_receptor addiction of prostate_cancer .
24895212	0	androgen	77,85	androgen_receptor	27,44	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	element|compound|START_ENTITY gene|nmod|element gene|compound|END_ENTITY	Negative regulation of the androgen_receptor gene through a primate-specific androgen response element present in the 5 ' UTR .
24945109	0	androgen	51,59	androgen_receptor	10,27	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	therapy|compound|START_ENTITY modulators|nmod|therapy modulators|nsubj|END_ENTITY	Selective androgen_receptor modulators as improved androgen therapy for advanced_breast_cancer .
2503662	0	androgen	24,32	androgen_receptor	101,118	androgen	androgen receptor	CHEBI:50113	11835(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY Differentiation|nmod|receptor mediated|nsubj|Differentiation mediated|nmod|FSH FSH|acl|using using|dobj|deficient deficient|compound|END_ENTITY	Differentiation between androgen and estrogen receptor mediated effects of testosterone on FSH using androgen_receptor deficient -LRB- Tfm -RRB- and normal mice .
25157703	0	androgen	88,96	androgen_receptor	28,45	androgen	androgen receptor	CHEBI:50113	11835(Tax:10090)	Chemical	Gene	roles|nmod|START_ENTITY reveals|dobj|roles reveals|nsubj|knockout knockout|nmod|END_ENTITY	Conditional knockout of the androgen_receptor in gonadotropes reveals crucial roles for androgen in gonadotropin synthesis and surge in female mice .
25398798	0	androgen	61,69	androgen_receptor	19,36	androgen	androgen receptor	CHEBI:50113	403588(Tax:9615)	Chemical	Gene	levels|compound|START_ENTITY relate|nmod|levels relate|nsubj|CAG-repeats CAG-repeats|nmod|gene gene|compound|END_ENTITY	CAG-repeats in the androgen_receptor gene relate with plasma androgen levels in the Bouvier Des Flandres .
25436691	0	androgen	22,30	androgen_receptor	68,85	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	action|compound|START_ENTITY Chaperones|nmod|action Chaperones|dep|plethora plethora|nmod|assistance assistance|nmod|function function|compound|END_ENTITY	Chaperones for proper androgen action - a plethora of assistance to androgen_receptor function .
25587594	1	androgen	77,85	androgen_receptor	40,57	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	deprivation|compound|START_ENTITY variants|nmod|deprivation variants|compound|END_ENTITY	Re : Rapid induction of androgen_receptor splice variants by androgen deprivation in prostate_cancer .
26137992	0	androgen	102,110	androgen_receptor	39,56	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	therapies|amod|START_ENTITY targeting|nmod|therapies inhibitor|xcomp|targeting inhibitor|nsubj|Discovery Discovery|nmod|ODM-201 ODM-201|appos|END_ENTITY	Discovery of ODM-201 , a new-generation androgen_receptor inhibitor targeting resistance mechanisms to androgen signaling-directed prostate cancer therapies .
26137992	0	androgen	102,110	androgen_receptor	39,56	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	therapies|amod|START_ENTITY targeting|nmod|therapies inhibitor|xcomp|targeting inhibitor|nsubj|Discovery Discovery|nmod|ODM-201 ODM-201|appos|END_ENTITY	Discovery of ODM-201 , a new-generation androgen_receptor inhibitor targeting resistance mechanisms to androgen signaling-directed prostate cancer therapies .
26715186	0	androgen	84,92	androgen_receptor	35,52	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	stimulation|compound|START_ENTITY alters|nmod|stimulation alters|nsubj|Transfection Transfection|nmod|cells cells|nmod|END_ENTITY	Transfection of Sertoli cells with androgen_receptor alters gene expression without androgen stimulation .
2755127	0	androgen	159,167	androgen_receptor	71,88	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	syndromes|amod|START_ENTITY patients|nmod|syndromes cells|nmod|patients complexes|nmod|cells detection|nmod|complexes purification|dep|detection purification|nmod|END_ENTITY	Partial purification and characterisation of the human skin fibroblast androgen_receptor : detection of abnormal receptor complexes in cells from patients with androgen insensitivity syndromes .
2885254	0	androgen	45,53	androgen_receptor	115,132	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	syndromes|amod|START_ENTITY families|nmod|syndromes RFLPs|nmod|families analysis|nmod|RFLPs analysis|dep|evidence evidence|nmod|linkage linkage|nmod|locus locus|compound|END_ENTITY	Linkage analysis with RFLPs in families with androgen resistance syndromes : evidence for close linkage between the androgen_receptor locus and the DXS1 segment .
2959494	0	androgen	41,49	androgen_receptor	20,37	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	dermatoses|amod|START_ENTITY END_ENTITY|nmod|dermatoses	Nuclear and cytosol androgen_receptor in androgen dependent dermatoses in female patients .
3346354	0	androgen	60,68	androgen_receptor	18,35	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	resistance|compound|START_ENTITY associated|nmod|resistance associated|nsubj|mutation mutation|nmod|END_ENTITY	A mutation of the androgen_receptor associated with partial androgen resistance , familial gynecomastia , and fertility .
3605226	0	androgen	8,16	androgen_receptor	75,92	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	resistance|compound|START_ENTITY due|nsubj|resistance due|nmod|defect defect|nmod|END_ENTITY	Partial androgen resistance due to a distinctive qualitative defect of the androgen_receptor .
6471235	0	androgen	48,56	androgen_receptor	20,37	androgen	androgen receptor	CHEBI:50113	24208(Tax:10116)	Chemical	Gene	responsiveness|compound|START_ENTITY levels|nmod|responsiveness levels|compound|END_ENTITY	The relationship of androgen_receptor levels to androgen responsiveness in the Dunning R3327 rat prostate tumor sublines .
6480833	0	androgen	10,18	androgen_receptor	114,131	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	therapy|compound|START_ENTITY therapy|nmod|END_ENTITY	High dose androgen therapy in male_pseudohermaphroditism due to 5_alpha-reductase_deficiency_and_disorders of the androgen_receptor .
6523537	0	androgen	124,132	androgen_receptor	8,25	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	molecules|amod|START_ENTITY reaction|nmod|molecules characterization|nmod|reaction END_ENTITY|dep|characterization	Cytosol androgen_receptor -LRB- AR -RRB- in human skin fibroblasts : characterization of the binding reaction and differentiation from androgen binding molecules of lower affinity .
6607139	0	androgen	90,98	androgen_receptor	15,32	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	insensitivity|compound|START_ENTITY patients|nmod|insensitivity investigation|nmod|patients Studies|dep|investigation Studies|nmod|END_ENTITY	Studies of the androgen_receptor in dispersed fibroblasts : investigation of patients with androgen insensitivity .
7511045	0	androgen	107,115	androgen_receptor	10,27	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	deprivation|compound|START_ENTITY cells|nmod|deprivation activity|nmod|cells activity|compound|END_ENTITY	Increased androgen_receptor activity and altered c-myc expression in prostate_cancer cells after long-term androgen deprivation .
7514587	0	androgen	39,47	androgen_receptor	6,23	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	element|amod|START_ENTITY binding|nmod|element END_ENTITY|xcomp|binding	Human androgen_receptor binding to the androgen response element of prostate_specific_antigen .
7533986	0	androgen	98,106	androgen_receptor	43,60	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	-RSB-|amod|START_ENTITY tool|nmod|-RSB- SSCP|dep|tool SSCP|nmod|detection detection|nmod|mutation mutation|compound|END_ENTITY	-LSB- Non-radioactive SSCP for the detection of androgen_receptor gene mutation -- a diagnostic tool for androgen resistance -RSB- .
7581399	0	androgen	6,14	androgen_receptor	93,110	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	START_ENTITY|xcomp|due due|nmod|mutations mutations|acl|encoding encoding|nmod|domain domain|amod|END_ENTITY	Human androgen insensitivity due to point mutations encoding amino_acid substitutions in the androgen_receptor steroid-binding domain .
7685765	0	androgen	77,85	androgen_receptor	116,133	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	gene|nmod|START_ENTITY repression|nmod|gene involve|nsubj|repression involve|dobj|binding binding|nmod|END_ENTITY	Transcriptional repression of the glycoprotein hormone alpha subunit gene by androgen may involve direct binding of androgen_receptor to the proximal promoter .
7821714	0	androgen	79,87	androgen_receptor	4,21	androgen	androgen receptor	CHEBI:50113	24208(Tax:10116)	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	The androgen_receptor of the urogenital tract of the fetal rat is regulated by androgen .
7951549	0	androgen	11,19	androgen_receptor	65,82	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	associated|nsubj|START_ENTITY associated|nmod|END_ENTITY	Incomplete androgen insensitivity associated with a thermolabile androgen_receptor .
7962294	0	androgen	38,46	androgen_receptor	3,20	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	resistance|compound|START_ENTITY causing|dobj|resistance mutation|acl|causing mutation|compound|END_ENTITY	An androgen_receptor mutation causing androgen resistance in undervirilized male syndrome .
7970939	0	androgen	122,130	androgen_receptor	41,58	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	insensitivity|compound|START_ENTITY approach|nmod|insensitivity approach|nmod|detection detection|nmod|mutations mutations|compound|END_ENTITY	A practical approach to the detection of androgen_receptor gene mutations and pedigree analysis in families with x-linked androgen insensitivity .
8158210	0	androgen	9,17	androgen_receptor	68,85	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	action|compound|START_ENTITY repeat|nsubj|action repeat|nmod|gene gene|compound|END_ENTITY	Aberrant androgen action and increased size of tandem CAG repeat in androgen_receptor gene in X-linked_recessive_bulbospinal_neuronopathy .
8216289	0	androgen	85,93	androgen_receptor	50,67	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	specificity|compound|START_ENTITY essential|nmod|specificity essential|nsubj|Threonine Threonine|nmod|868 868|nmod|END_ENTITY	Threonine on amino_acid position 868 in the human androgen_receptor is essential for androgen binding specificity and functional activity .
8281140	0	androgen	84,92	androgen_receptor	44,61	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	causing|dobj|START_ENTITY causing|nsubj|substitution substitution|nmod|exon exon|nmod|gene gene|compound|END_ENTITY	A single-base substitution in exon 6 of the androgen_receptor gene causing complete androgen insensitivity : the mutated receptor fails to transactivate but binds to DNA in vitro .
8325950	0	androgen	102,110	androgen_receptor	52,69	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	syndromes|amod|START_ENTITY patients|nmod|syndromes strand|nmod|patients strand|dobj|analysis analysis|nmod|mutations mutations|compound|END_ENTITY	Single strand conformation polymorphism analysis of androgen_receptor gene mutations in patients with androgen insensitivity syndromes : application for diagnosis , genetic counseling , and therapy .
8413310	0	androgen	115,123	androgen_receptor	76,93	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	insensitivity|compound|START_ENTITY causes|dobj|insensitivity causes|nsubj|mutation mutation|nmod|finger finger|nmod|domain domain|nmod|gene gene|compound|END_ENTITY	A point mutation in the second zinc finger of the DNA-binding domain of the androgen_receptor gene causes complete androgen insensitivity in two siblings with receptor-positive androgen resistance .
8413310	0	androgen	177,185	androgen_receptor	76,93	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	resistance|compound|START_ENTITY siblings|nmod|resistance insensitivity|nmod|siblings causes|dobj|insensitivity causes|nsubj|mutation mutation|nmod|finger finger|nmod|domain domain|nmod|gene gene|compound|END_ENTITY	A point mutation in the second zinc finger of the DNA-binding domain of the androgen_receptor gene causes complete androgen insensitivity in two siblings with receptor-positive androgen resistance .
8413317	0	androgen	92,100	androgen_receptor	60,77	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Transcriptional and posttranscriptional regulation of human androgen_receptor expression by androgen .
8419121	0	androgen	106,114	androgen_receptor	31,48	androgen	androgen receptor	CHEBI:50113	24208(Tax:10116)	Chemical	Gene	withdrawal|compound|START_ENTITY lobes|nmod|withdrawal lobes|nsubj|analysis analysis|nmod|END_ENTITY	Immunocytochemical analysis of androgen_receptor along the ducts of the separate rat prostate lobes after androgen withdrawal and replacement .
8421085	2	androgen	107,115	androgen_receptor	72,89	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	resistance|compound|START_ENTITY causes|dobj|resistance gene|acl:relcl|causes gene|compound|END_ENTITY	The spectrum of mutations in the androgen_receptor gene that causes androgen resistance .
8446106	0	androgen	110,118	androgen_receptor	161,178	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	causes|dobj|START_ENTITY causes|nmod|phenotypes phenotypes|compound|END_ENTITY	Substitution of valine-865_by_methionine_or_leucine in the human androgen_receptor causes complete or partial androgen insensitivity , respectively with distinct androgen_receptor phenotypes .
8446106	0	androgen	110,118	androgen_receptor	65,82	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	causes|dobj|START_ENTITY causes|nsubj|Substitution Substitution|nmod|valine-865_by_methionine_or_leucine valine-865_by_methionine_or_leucine|nmod|END_ENTITY	Substitution of valine-865_by_methionine_or_leucine in the human androgen_receptor causes complete or partial androgen insensitivity , respectively with distinct androgen_receptor phenotypes .
8626869	0	androgen	89,97	androgen_receptor	50,67	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	resistance|compound|START_ENTITY causes|dobj|resistance causes|nsubj|substitution substitution|nmod|exon exon|nmod|gene gene|compound|END_ENTITY	A novel substitution -LRB- Leu707Arg -RRB- in exon 4 of the androgen_receptor gene causes complete androgen resistance .
8683781	0	androgen	15,23	androgen_receptor	50,67	androgen	androgen receptor	CHEBI:50113	24208(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY effects|nmod|administration effects|nmod|expression expression|compound|END_ENTITY	The effects of androgen administration on phallic androgen_receptor expression .
8925904	0	androgen	84,92	androgen_receptor	34,51	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	absent|nmod|START_ENTITY absent|nsubj|up-regulation up-regulation|nmod|transcription transcription|compound|END_ENTITY	Second messenger up-regulation of androgen_receptor gene transcription is absent in androgen insensitive human prostatic_carcinoma cell lines , PC-3 and DU-145 .
8961268	0	androgen	4,12	androgen_receptor	38,55	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	elements|compound|START_ENTITY elements|nmod|region region|compound|END_ENTITY	Two androgen response elements in the androgen_receptor coding region are required for cell-specific up-regulation of receptor messenger RNA .
9007482	0	androgen	53,61	androgen_receptor	108,125	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	sensitivity|compound|START_ENTITY assessment|nmod|sensitivity assessment|nmod|patients patients|nmod|mutations mutations|nmod|gene gene|compound|END_ENTITY	Functional assessment and clinical classification of androgen sensitivity in patients with mutations of the androgen_receptor gene .
9032526	0	androgen	64,72	androgen_receptor	6,23	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	ablation|compound|START_ENTITY prostate_cancer|nmod|ablation END_ENTITY|nmod|prostate_cancer	Human androgen_receptor expression in prostate_cancer following androgen ablation .
9048634	0	androgen	32,40	androgen_receptor	52,69	androgen	androgen receptor	CHEBI:50113	24208(Tax:10116)	Chemical	Gene	analysis|nmod|START_ENTITY effects|nsubj|analysis effects|nmod|expression expression|compound|END_ENTITY	Immunohistochemical analysis of androgen effects on androgen_receptor expression in developing Leydig and Sertoli cells .
9215398	0	androgen	47,55	androgen_receptor	26,43	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Synergistic activation of androgen_receptor by androgen and luteinizing hormone-releasing hormone in prostatic_carcinoma cells .
9219921	0	androgen	94,102	androgen_receptor	146,163	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	blockade|compound|START_ENTITY blockade|acl|-LSB- -LSB-|nmod|END_ENTITY	4-Methyl-3-oxo-4-aza-5alpha-androst-1-ene-17beta-N-aryl-carboxamides : an approach to combined androgen blockade -LSB- 5alpha-reductase inhibition with androgen_receptor binding in vitro -RSB- .
9417052	0	androgen	118,126	androgen_receptor	54,71	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	cause|dobj|START_ENTITY mutations|acl:relcl|cause revealed|nmod|mutations dimerization|acl|revealed dimerization|compound|END_ENTITY	Intermolecular NH2 - / carboxyl-terminal interactions in androgen_receptor dimerization revealed by mutations that cause androgen insensitivity .
9607727	0	androgen	8,16	androgen_receptor	102,119	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	insensitivity|compound|START_ENTITY predicted|nsubj|insensitivity predicted|dobj|structure structure|nmod|ligand-binding_domain ligand-binding_domain|compound|END_ENTITY	Partial androgen insensitivity and correlations with the predicted three dimensional structure of the androgen_receptor ligand-binding_domain .
9816170	0	androgen	100,108	androgen_receptor	17,34	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	independence|compound|START_ENTITY associated|nmod|independence associated|nsubjpass|Mutations Mutations|nmod|gene gene|compound|END_ENTITY	Mutations in the androgen_receptor gene are associated with progression of human prostate_cancer to androgen independence .
9895128	0	androgen	95,103	androgen_receptor	56,73	androgen	androgen receptor	CHEBI:50113	367	Chemical	Gene	causes|dobj|START_ENTITY causes|nsubj|mutation mutation|nmod|domain domain|nmod|gene gene|compound|END_ENTITY	Frame-shift mutation in hormone binding domain of human androgen_receptor gene causes complete androgen insensitivity .
22298898	0	androgen	37,45	b-catenin	14,23	androgen	b-catenin	CHEBI:50113	1499	Chemical	Gene	cells|amod|START_ENTITY signaling|nmod|cells Activation|acl|signaling Activation|nmod|END_ENTITY	Activation of b-catenin signaling in androgen receptor-negative prostate_cancer cells .
12390831	0	androgen	12,20	basic_fibroblast_growth_factor	56,86	androgen	basic fibroblast growth factor	CHEBI:50113	2247	Chemical	Gene	START_ENTITY|nmod|expressions expressions|nmod|END_ENTITY	-LSB- Effects of androgen and estrogen on the expressions of basic_fibroblast_growth_factor , transforming growth factor and smoothelin -RSB- .
8189222	0	androgen	14,22	beta_subunit_of_nerve_growth_factor	40,75	androgen	beta subunit of nerve growth factor	CHEBI:50113	18049(Tax:10090)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation by androgen of levels of the beta_subunit_of_nerve_growth_factor and its mRNA in selected regions of the mouse brain .
6425273	0	androgen	33,41	cytochrome_b5	16,29	androgen	cytochrome b5	CHEBI:50113	64001(Tax:10116)	Chemical	Gene	synthesis|compound|START_ENTITY END_ENTITY|nmod|synthesis	Contribution of cytochrome_b5 to androgen synthesis in rat testicular microsomes .
12298427	0	androgen	20,28	erythropoietin	132,146	androgen	erythropoietin	CHEBI:50113	2056	Chemical	Gene	Effects|nmod|START_ENTITY hemodialysis|nsubj|Effects hemodialysis|dobj|patients patients|acl|using using|dobj|END_ENTITY	Effects of adjuvant androgen on anemia and nutritional parameters in chronic hemodialysis patients using low-dose recombinant human erythropoietin .
12931361	0	androgen	11,19	erythropoietin	23,37	androgen	erythropoietin	CHEBI:50113	2056	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of androgen on erythropoietin in patients with hypogonadism -RSB- .
15778925	0	androgen	13,21	erythropoietin	101,115	androgen	erythropoietin	CHEBI:50113	2056	Chemical	Gene	deprivation|compound|START_ENTITY Anemia|nmod|deprivation Anemia|dep|influence influence|nmod|system system|compound|END_ENTITY	Anemia under androgen deprivation : influence of flutamide , cyproteroneacetate and orchiectomy on the erythropoietin system .
1705094	0	androgen	21,29	erythropoietin	81,95	androgen	erythropoietin	CHEBI:50113	2056	Chemical	Gene	deprivation|compound|START_ENTITY Effect|nmod|deprivation immunoreactive|nsubj|Effect immunoreactive|dobj|END_ENTITY	Effect of reversible androgen deprivation on hemoglobin and serum immunoreactive erythropoietin in men .
7477614	0	androgen	40,48	erythropoietin	19,33	androgen	erythropoietin	CHEBI:50113	2056	Chemical	Gene	administration|compound|START_ENTITY END_ENTITY|nmod|administration	Evolution of serum erythropoietin after androgen administration to hemodialysis patients : a prospective study .
9462542	0	androgen	10,18	erythropoietin	47,61	androgen	erythropoietin	CHEBI:50113	2056	Chemical	Gene	therapy|compound|START_ENTITY Effect|nmod|therapy Effect|nmod|levels levels|compound|END_ENTITY	Effect of androgen therapy and anemia on serum erythropoietin levels in patients with aplastic_anemia and myelodysplastic_syndromes .
7521961	0	androgen	32,40	fibroblast_growth_factor-2	44,70	androgen	fibroblast growth factor-2	CHEBI:50113	2247	Chemical	Gene	START_ENTITY|nmod|concentrations concentrations|amod|END_ENTITY	In vivo and in vitro effects of androgen on fibroblast_growth_factor-2 concentrations in the human prostate .
11158004	0	androgen	10,18	gonadotropin-releasing_hormone	58,88	androgen	gonadotropin-releasing hormone	CHEBI:50113	2796	Chemical	Gene	feedback|amod|START_ENTITY Muting|nmod|feedback unveils|nsubj|Muting unveils|dobj|/ /|amod|END_ENTITY	Muting of androgen negative feedback unveils impoverished gonadotropin-releasing_hormone / luteinizing hormone secretory reactivity in healthy older men .
12403848	0	androgen	91,99	gonadotropin-releasing_hormone	27,57	androgen	gonadotropin-releasing hormone	CHEBI:50113	2796	Chemical	Gene	secretion|nmod|START_ENTITY secretion|amod|END_ENTITY	Differential regulation of gonadotropin-releasing_hormone secretion and gene expression by androgen : membrane versus nuclear receptor activation .
1592863	0	androgen	14,22	gonadotropin-releasing_hormone	64,94	androgen	gonadotropin-releasing hormone	CHEBI:50113	2796	Chemical	Gene	feedback|amod|START_ENTITY Evidence|dep|feedback regulates|nsubj|Evidence regulates|dobj|strength strength|amod|END_ENTITY	Evidence that androgen negative feedback regulates hypothalamic gonadotropin-releasing_hormone impulse strength and the burst-like secretion of biologically active luteinizing hormone in men .
21458314	0	androgen	114,122	gonadotropin-releasing_hormone	148,178	androgen	gonadotropin-releasing hormone	CHEBI:50113	2796	Chemical	Gene	therapy|amod|START_ENTITY receiving|dobj|therapy receiving|nmod|analogues analogues|amod|END_ENTITY	Insulin-like_growth_factor-1 is associated with regulation of the luteinizing hormone production in men receiving androgen deprivation therapy with gonadotropin-releasing_hormone analogues for localized_prostate_cancer .
2465302	0	androgen	145,153	gonadotropin-releasing_hormone	41,71	androgen	gonadotropin-releasing hormone	CHEBI:50113	2796	Chemical	Gene	concentration|compound|START_ENTITY effects|nmod|concentration treatment|dep|effects treatment|nmod|agonist agonist|amod|END_ENTITY	Three-month treatment with a long-acting gonadotropin-releasing_hormone agonist of patients with benign_prostatic_hyperplasia : effects on tissue androgen concentration , 5_alpha-reductase activity and androgen receptor content .
3144190	0	androgen	73,81	gonadotropin-releasing_hormone	28,58	androgen	gonadotropin-releasing hormone	CHEBI:50113	25194(Tax:10116)	Chemical	Gene	supplementation|compound|START_ENTITY combined|nmod|supplementation END_ENTITY|acl|combined	Active immunization against gonadotropin-releasing_hormone combined with androgen supplementation is a promising antifertility vaccine for males .
3275542	0	androgen	61,69	gonadotropin-releasing_hormone	2,32	androgen	gonadotropin-releasing hormone	CHEBI:50113	2796	Chemical	Gene	production|compound|START_ENTITY production|amod|END_ENTITY	A gonadotropin-releasing_hormone -LRB- GnRH -RRB- antagonist decreases androgen production and spermatogonial multiplication in frog -LRB- Rana esculenta -RRB- : indirect evidence for the existence of GnRH or GnRH-like material receptors in the hypophysis and testis .
3918377	0	androgen	102,110	gonadotropin-releasing_hormone	44,74	androgen	gonadotropin-releasing hormone	CHEBI:50113	2796	Chemical	Gene	production|compound|START_ENTITY Evaluation|nmod|production Evaluation|nmod|analogue analogue|nmod|END_ENTITY	Evaluation of synthetic agonist analogue of gonadotropin-releasing_hormone -LRB- leuprolide -RRB- on testicular androgen production in patients with carcinoma_of_prostate .
8045961	0	androgen	88,96	gonadotropin-releasing_hormone	41,71	androgen	gonadotropin-releasing hormone	CHEBI:50113	2796	Chemical	Gene	suppression|compound|START_ENTITY suppression|amod|END_ENTITY	Estrogen replacement does not potentiate gonadotropin-releasing_hormone agonist-induced androgen suppression in treatment of hirsutism .
8540290	0	androgen	14,22	gonadotropin-releasing_hormone	134,164	androgen	gonadotropin-releasing hormone	CHEBI:50113	2796	Chemical	Gene	levels|compound|START_ENTITY Comparison|nmod|levels Comparison|nmod|stimulation stimulation|acl|using using|dobj|protocol protocol|amod|END_ENTITY	Comparison of androgen levels in conception vs. non-conception cycles following controlled ovarian stimulation using the luteal phase gonadotropin-releasing_hormone agonist protocol .
8697573	0	androgen	11,19	gonadotropin-releasing_hormone	35,65	androgen	gonadotropin-releasing hormone	CHEBI:50113	2796	Chemical	Gene	suppression|compound|START_ENTITY suppression|nmod|agonist agonist|amod|END_ENTITY	Effects of androgen suppression by gonadotropin-releasing_hormone agonist and flutamide on lipid metabolism in men with prostate_cancer : focus on lipoprotein -LRB- a -RRB- .
9130889	0	androgen	68,76	gonadotropin-releasing_hormone	135,165	androgen	gonadotropin-releasing hormone	CHEBI:50113	2796	Chemical	Gene	synthesis|compound|START_ENTITY Girls|dep|synthesis Girls|dep|evidence evidence|nmod|testing testing|amod|END_ENTITY	Girls diagnosed with premature_pubarche show an exaggerated ovarian androgen synthesis from the early stages of puberty : evidence from gonadotropin-releasing_hormone agonist testing .
12699442	0	androgen	60,68	growth_hormone	14,28	androgen	growth hormone	CHEBI:50113	2688	Chemical	Gene	therapy|nmod|START_ENTITY therapy|amod|END_ENTITY	The effect of growth_hormone replacement therapy on adrenal androgen secretion in adult onset hypopituitarism .
12795360	0	androgen	142,150	growth_hormone	76,90	androgen	growth hormone	CHEBI:50113	2688	Chemical	Gene	modulation|nmod|START_ENTITY control|dep|modulation control|nmod|modes modes|nmod|secretion secretion|amod|END_ENTITY	Three-peptide control of pulsatile and entropic feedback-sensitive modes of growth_hormone secretion : modulation by estrogen and aromatizable androgen .
17852425	0	androgen	127,135	growth_hormone	9,23	androgen	growth hormone	CHEBI:50113	2688	Chemical	Gene	related|nmod|START_ENTITY related|csubj|Impaired Impaired|dobj|secretion secretion|amod|END_ENTITY	Impaired growth_hormone secretion after glucose loading in non-obese women with polycystic_ovary_syndrome , possibly related to androgen but not insulin and free fatty_acids .
19620932	0	androgen	18,26	growth_hormone	37,51	androgen	growth hormone	CHEBI:50113	2688	Chemical	Gene	use|compound|START_ENTITY use|compound|END_ENTITY	Position stand on androgen and human growth_hormone use .
19760629	0	androgen	67,75	growth_hormone	124,138	androgen	growth hormone	CHEBI:50113	2688	Chemical	Gene	therapy|compound|START_ENTITY receiving|dobj|therapy prostate_cancer|acl|receiving patients|nmod|prostate_cancer metabolic_disorder|nmod|patients metabolic_disorder|dep|impact impact|nmod|ADT ADT|nmod|axis axis|amod|END_ENTITY	Bone metabolic_disorder in patients with prostate_cancer receiving androgen deprivation therapy -LRB- ADT -RRB- : impact of ADT on the growth_hormone / insulin-like_growth_factor-1 / parathyroid_hormone axis .
2401714	0	androgen	48,56	growth_hormone	100,114	androgen	growth hormone	CHEBI:50113	2688	Chemical	Gene	Testosterone|appos|START_ENTITY amplify|nsubj|Testosterone amplify|dobj|mass mass|nmod|duration duration|amod|END_ENTITY	Testosterone and oxandrolone , a nonaromatizable androgen , specifically amplify the mass and rate of growth_hormone -LRB- GH -RRB- secreted per burst without altering GH secretory burst duration or frequency or the GH half-life .
2609899	0	androgen	105,113	growth_hormone	25,39	androgen	growth hormone	CHEBI:50113	2688	Chemical	Gene	insensitivity|compound|START_ENTITY children|nmod|insensitivity Effect|nmod|children Effect|nmod|steroids steroids|compound|END_ENTITY	Effect of gonadectomy on growth_hormone , IGF-I and sex steroids in children with complete and incomplete androgen insensitivity .
3575334	0	androgen	9,17	growth_hormone	55,69	androgen	growth hormone	CHEBI:50113	443329(Tax:9940)	Chemical	Gene	exposure|compound|START_ENTITY exposure|nmod|END_ENTITY	Prenatal androgen exposure and growth and secretion of growth_hormone and prolactin in ewes postweaning .
3653034	0	androgen	45,53	growth_hormone	68,82	androgen	growth hormone	CHEBI:50113	81668(Tax:10116)	Chemical	Gene	imprinting|compound|START_ENTITY imprinting|nmod|secretion secretion|amod|END_ENTITY	Inhibitory effect of the ovaries on neonatal androgen imprinting of growth_hormone secretion in female rats .
463446	0	androgen	10,18	growth_hormone	22,36	androgen	growth hormone	CHEBI:50113	2688	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|amod|END_ENTITY	Effect of androgen on growth_hormone secretion and growth in boys with short_stature .
8630518	0	androgen	45,53	growth_hormone	10,24	androgen	growth hormone	CHEBI:50113	2688	Chemical	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	Effect of growth_hormone on follicular fluid androgen levels in patients treated with gonadotropins before in_vitro_fertilization .
1479151	0	androgen	96,104	hCG	19,22	androgen	hCG	CHEBI:50113	3342	Chemical	Gene	resistance|compound|START_ENTITY patient|nmod|resistance tissue|nmod|patient steroidogenesis|nmod|tissue END_ENTITY|nmod|steroidogenesis	In vitro effect of hCG on steroidogenesis in the testicular tissue from a patient with complete androgen resistance .
12853842	0	androgen	66,74	hTERT	22,27	androgen	hTERT	CHEBI:50113	7015	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	In vivo regulation of hTERT expression and telomerase activity by androgen .
21056661	0	androgen	108,116	hypoxia-inducible_factor-1a	71,98	androgen	hypoxia-inducible factor-1a	CHEBI:50113	3091	Chemical	Gene	environment|compound|START_ENTITY END_ENTITY|nmod|environment	Hypoxia enhances transcriptional activity of androgen_receptor through hypoxia-inducible_factor-1a in a low androgen environment .
12048740	0	androgen	66,74	insulin	34,41	androgen	insulin	CHEBI:50113	3630	Chemical	Gene	tumor|amod|START_ENTITY mimicking|dobj|tumor resistance|acl|mimicking resistance|compound|END_ENTITY	Hyperandrogenemia associated with insulin resistance mimicking an androgen producing tumor .
1321739	0	androgen	13,21	insulin	124,131	androgen	insulin	CHEBI:50113	3630	Chemical	Gene	response|compound|START_ENTITY response|dep|relationship relationship|nmod|secretion secretion|compound|END_ENTITY	Differential androgen response to adrenocorticotropic hormone stimulation in polycystic_ovarian_syndrome : relationship with insulin secretion .
1601743	0	androgen	31,39	insulin	91,98	androgen	insulin	CHEBI:50113	3630	Chemical	Gene	receptors|compound|START_ENTITY methyltrienolone|nmod|receptors fibroblasts|amod|methyltrienolone Binding|nmod|fibroblasts enhanced|nsubjpass|Binding enhanced|nmod|END_ENTITY	Binding of methyltrienolone to androgen receptors in human skin fibroblasts is enhanced by insulin .
16764619	0	androgen	44,52	insulin	24,31	androgen	insulin	CHEBI:50113	3630	Chemical	Gene	rates|dep|START_ENTITY rates|compound|END_ENTITY	Effects of metformin on insulin resistance , androgen concentration , ovulation and pregnancy rates in women with polycystic_ovary_syndrome following laparoscopic ovarian_drilling .
17202144	0	androgen	57,65	insulin	29,36	androgen	insulin	CHEBI:50113	3630	Chemical	Gene	activates|dobj|START_ENTITY activates|nsubj|signaling signaling|compound|END_ENTITY	Insulin-like_growth_factor_1 / insulin signaling activates androgen signaling through direct interactions of Foxo1 with androgen_receptor .
1742883	0	androgen	79,87	insulin	22,29	androgen	insulin	CHEBI:50113	3630	Chemical	Gene	transport|compound|START_ENTITY indices|nmod|transport Correlation|nmod|indices Correlation|nmod|END_ENTITY	Correlation of plasma insulin and insulin-like_growth_factor-I with indices of androgen transport and metabolism in women with polycystic_ovary_syndrome .
18220653	0	androgen	19,27	insulin	36,43	androgen	insulin	CHEBI:50113	3630	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	Role of endogenous androgen against insulin resistance and athero - _ sclerosis in men with type 2 diabetes .
18615851	0	androgen	52,60	insulin	24,31	androgen	insulin	CHEBI:50113	3630	Chemical	Gene	excess|compound|START_ENTITY Effects|parataxis|excess Effects|nmod|androgens androgens|nmod|action action|compound|END_ENTITY	Effects of androgens on insulin action in women : is androgen excess a component of female metabolic_syndrome ?
18684447	0	androgen	38,46	insulin	10,17	androgen	insulin	CHEBI:50113	3630	Chemical	Gene	production|compound|START_ENTITY Effect|nmod|production Effect|nmod|END_ENTITY	Effect of insulin and testosterone on androgen production and transcription of SULT2A1 in the NCI-H295R adrenocortical cell line .
2585395	0	androgen	53,61	insulin	11,18	androgen	insulin	CHEBI:50113	3630	Chemical	Gene	levels|compound|START_ENTITY resistance|nmod|levels resistance|compound|END_ENTITY	Persistent insulin resistance after normalization of androgen levels in a woman with congenital_adrenal_hyperplasia .
27060006	8	androgen	1237,1245	insulin	1278,1285	androgen	insulin	CHEBI:50113	3630	Chemical	Gene	exerted|nsubj|START_ENTITY exerted|dep|signaling signaling|nsubj|influence influence|nmod|END_ENTITY	In conclusion , insulin activates PI3-K/Akt signaling pathway and promotes lactate production in ovarian GCs , but high androgen exerted no obvious influence on insulin signaling pathway and metabolic effect in GCs , suggesting that metabolic actions of insulin in ovarian GCs were unaffected by hyperandrogenism directly .
3554068	0	androgen	48,56	insulin	69,76	androgen	insulin	CHEBI:50113	3630	Chemical	Gene	response|compound|START_ENTITY response|nmod|infusion infusion|compound|END_ENTITY	Hyperinsulinemia and hyperandrogenemia : in vivo androgen response to insulin infusion .
6370422	0	androgen	151,159	insulin	28,35	androgen	insulin	CHEBI:50113	280829(Tax:9913)	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|prolactin prolactin|compound|END_ENTITY	Direct mitogenic effects of insulin , epidermal_growth_factor , glucocorticoid , cholera toxin , unknown pituitary factors and possibly prolactin , but not androgen , on normal rat prostate epithelial cells in serum-free , primary cell culture .
7714138	0	androgen	13,21	insulin	110,117	androgen	insulin	CHEBI:50113	3630	Chemical	Gene	response|compound|START_ENTITY Differential|dobj|response Differential|xcomp|adrenocorticotrophin adrenocorticotrophin|nmod|secretion secretion|compound|END_ENTITY	Differential androgen response to adrenocorticotrophin hormone stimulation and effect of opioid antagonist on insulin secretion in polycystic_ovarian_syndrome .
1360928	0	androgen	39,47	insulin-like_growth_factor-I	58,86	androgen	insulin-like growth factor-I	CHEBI:50113	24482(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Growth_hormone and prolactin stimulate androgen receptor , insulin-like_growth_factor-I -LRB- IGF-I -RRB- and IGF-I_receptor levels in the prostate of immature rats .
1597396	0	androgen	43,51	insulin-like_growth_factor-I	11,39	androgen	insulin-like growth factor-I	CHEBI:50113	24482(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY Effects|nmod|production Effects|nmod|END_ENTITY	Effects of insulin-like_growth_factor-I on androgen production by highly purified pubertal and adult rat Leydig cells .
1874169	0	androgen	94,102	interleukin-1	50,63	androgen	interleukin-1	CHEBI:50113	3552	Chemical	Gene	biosynthesis|compound|START_ENTITY inhibits|dep|biosynthesis inhibits|amod|END_ENTITY	Cytokine-mediated regulation of ovarian function : interleukin-1 inhibits gonadotropin-induced androgen biosynthesis .
8783045	0	androgen	38,46	interleukin-1	14,27	androgen	interleukin-1	CHEBI:50113	3552	Chemical	Gene	metabolism|compound|START_ENTITY effect|nmod|metabolism effect|nmod|END_ENTITY	The effect of interleukin-1 -LRB- IL-1 -RRB- on androgen metabolism in human gingival tissue -LRB- HGT -RRB- and periodontal ligament -LRB- PDL -RRB- .
19844233	0	androgen	24,32	interleukin-6	69,82	androgen	interleukin-6	CHEBI:50113	3569	Chemical	Gene	START_ENTITY|nmod|overexpression overexpression|nmod|cells cells|amod|END_ENTITY	Enhanced sensitivity to androgen withdrawal due to overexpression of interleukin-6 in androgen-dependent human prostate_cancer LNCaP cells .
9348243	0	androgen	20,28	interleukin-6	118,131	androgen	interleukin-6	CHEBI:50113	3569	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|role role|nmod|END_ENTITY	Autocrine effect of androgen on proliferation of an androgen responsive prostatic_carcinoma cell line , LNCAP : role of interleukin-6 .
9348243	0	androgen	52,60	interleukin-6	118,131	androgen	interleukin-6	CHEBI:50113	3569	Chemical	Gene	responsive|amod|START_ENTITY line|amod|responsive proliferation|nmod|line androgen|nmod|proliferation effect|nmod|androgen effect|dep|role role|nmod|END_ENTITY	Autocrine effect of androgen on proliferation of an androgen responsive prostatic_carcinoma cell line , LNCAP : role of interleukin-6 .
10510930	0	androgen	101,109	luteinizing_hormone-releasing_hormone	25,62	androgen	luteinizing hormone-releasing hormone	CHEBI:50113	2796	Chemical	Gene	ablation|compound|START_ENTITY schedule|nmod|ablation schedule|amod|END_ENTITY	Serum testosterone-based luteinizing_hormone-releasing_hormone agonist redosing schedule for chronic androgen ablation : a phase I assessment .
24100643	0	androgen	29,37	luteinizing_hormone-releasing_hormone	105,142	androgen	luteinizing hormone-releasing hormone	CHEBI:50113	2796	Chemical	Gene	therapy|compound|START_ENTITY association|nmod|therapy association|dep|expression expression|nmod|receptor receptor|amod|END_ENTITY	Emerging association between androgen deprivation therapy and male_meningioma : significant expression of luteinizing_hormone-releasing_hormone receptor in male_meningioma .
6800852	0	androgen	20,28	luteinizing_hormone-releasing_hormone	102,139	androgen	luteinizing hormone-releasing hormone	CHEBI:50113	2796	Chemical	Gene	levels|compound|START_ENTITY levels|nmod|intranasal intranasal|nmod|END_ENTITY	Inhibition of serum androgen levels by chronic intranasal and subcutaneous administration of a potent luteinizing_hormone-releasing_hormone -LRB- LH-RH -RRB- agonist in adult men .
797646	0	androgen	19,27	luteinizing_hormone-releasing_hormone	88,125	androgen	luteinizing hormone-releasing hormone	CHEBI:50113	25194(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of neonatal androgen on the activity of peptidases in the rat brain inactivating luteinizing_hormone-releasing_hormone .
15138554	0	androgen	56,64	matrix_metalloproteinase_13	14,41	androgen	matrix metalloproteinase 13	CHEBI:50113	4322	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of matrix_metalloproteinase_13 expression by androgen in prostate_cancer .
24648996	0	androgen	52,60	metallothionein_3	15,32	androgen	metallothionein 3	CHEBI:50113	4504	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Suppression of metallothionein_3 gene expression by androgen in LNCaP prostate_cancer cells .
9324042	0	androgen	65,73	mouse_vas_deferens_protein	92,118	androgen	mouse vas deferens protein	CHEBI:50113	11997(Tax:10090)	Chemical	Gene	activation|compound|START_ENTITY activation|nmod|promoter promoter|compound|END_ENTITY	Ubiquitous transcription factors NF1 and Sp1 are involved in the androgen activation of the mouse_vas_deferens_protein promoter .
10619359	0	androgen	13,21	ornithine_decarboxylase	97,120	androgen	ornithine decarboxylase	CHEBI:50113	4953	Chemical	Gene	sensitivity|compound|START_ENTITY associated|nsubjpass|sensitivity associated|nmod|heterogeneity heterogeneity|nmod|metabolism metabolism|appos|regulation regulation|amod|END_ENTITY	Differential androgen sensitivity is associated with clonal heterogeneity in steroid metabolism , ornithine_decarboxylase regulation and IL-1alpha action in mouse mammary_tumor cells .
1537280	0	androgen	14,22	ornithine_decarboxylase	37,60	androgen	ornithine decarboxylase	CHEBI:50113	18263(Tax:10090)	Chemical	Gene	regulation|compound|START_ENTITY Comparison|nmod|regulation Comparison|nmod|expression expression|compound|END_ENTITY	Comparison of androgen regulation of ornithine_decarboxylase and S-adenosylmethionine_decarboxylase gene expression in rodent kidney and accessory sex organs .
21153204	0	androgen	25,33	ornithine_decarboxylase	98,121	androgen	ornithine decarboxylase	CHEBI:50113	4953	Chemical	Gene	responsive|amod|START_ENTITY DDT|amod|responsive inhibition|nmod|DDT inhibition|dep|role role|nmod|END_ENTITY	Growth inhibition of the androgen responsive DDT -LRB- 1 -RRB- MF-2 cell line by glucocorticoids : the role of ornithine_decarboxylase .
3453893	0	androgen	21,29	ornithine_decarboxylase	44,67	androgen	ornithine decarboxylase	CHEBI:50113	18263(Tax:10090)	Chemical	Gene	regulation|compound|START_ENTITY variation|nmod|regulation variation|nmod|expression expression|amod|END_ENTITY	Genetic variation in androgen regulation of ornithine_decarboxylase gene expression in inbred strains of mice .
15042606	0	androgen	91,99	osteoprotegerin	6,21	androgen	osteoprotegerin	CHEBI:50113	4982	Chemical	Gene	associated|xcomp|START_ENTITY associated|nsubjpass|levels levels|compound|END_ENTITY	Serum osteoprotegerin -LRB- OPG -RRB- levels are associated with disease progression and response to androgen ablation in patients with prostate_cancer .
22967165	0	androgen	67,75	osteoprotegerin	32,47	androgen	osteoprotegerin	CHEBI:50113	25341(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Eurycoma longifolia upregulates osteoprotegerin gene expression in androgen - deficient osteoporosis rat model .
19760629	0	androgen	67,75	parathyroid_hormone	168,187	androgen	parathyroid hormone	CHEBI:50113	5741	Chemical	Gene	therapy|compound|START_ENTITY receiving|dobj|therapy prostate_cancer|acl|receiving patients|nmod|prostate_cancer metabolic_disorder|nmod|patients metabolic_disorder|dep|impact impact|nmod|ADT ADT|nmod|axis axis|amod|END_ENTITY	Bone metabolic_disorder in patients with prostate_cancer receiving androgen deprivation therapy -LRB- ADT -RRB- : impact of ADT on the growth_hormone / insulin-like_growth_factor-1 / parathyroid_hormone axis .
20812209	0	androgen	46,54	pleiotrophin	14,26	androgen	pleiotrophin	CHEBI:50113	5764	Chemical	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of pleiotrophin in the prostate is androgen regulated and it functions as an autocrine regulator of mesenchyme and cancer associated fibroblasts and as a paracrine regulator of epithelia .
3132311	0	androgen	78,86	prealbumin	108,118	androgen	prealbumin	CHEBI:50113	22139(Tax:10090)	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Localization , on the head of ram spermatozoa , of affinity sites for the 64kD androgen dependent epididymal prealbumin -RSB- .
8446105	0	androgen	64,72	probasin	91,99	androgen	probasin	CHEBI:50113	103689993	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|gene gene|compound|END_ENTITY	Characterization of two cis-acting DNA elements involved in the androgen regulation of the probasin gene .
12210477	0	androgen	103,111	prolactin	42,51	androgen	prolactin	CHEBI:50113	19109(Tax:10090)	Chemical	Gene	levels|compound|START_ENTITY dependent|nmod|levels dependent|nsubj|prostate_hyperplasia prostate_hyperplasia|nmod|transgenic_mice transgenic_mice|compound|END_ENTITY	Progressive prostate_hyperplasia in adult prolactin transgenic_mice is not dependent on elevated serum androgen levels .
235637	0	androgen	23,31	prolactin	10,19	androgen	prolactin	CHEBI:50113	100499538	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	Effect of prolactin on androgen metabolism by the guinea-pig sex accessory organs .
3969372	0	androgen	69,77	prolactin	20,29	androgen	prolactin	CHEBI:50113	24683(Tax:10116)	Chemical	Gene	action|compound|START_ENTITY independent|nmod|action action|dep|independent action|nmod|END_ENTITY	Metabolic action of prolactin in regressing prostate : independent of androgen action .
558871	0	androgen	5,13	prolactin	24,33	androgen	prolactin	CHEBI:50113	24683(Tax:10116)	Chemical	Gene	influence|nsubj|START_ENTITY influence|dobj|secretion secretion|compound|END_ENTITY	Does androgen influence prolactin secretion ?
6494057	0	androgen	78,86	prolactin	10,19	androgen	prolactin	CHEBI:50113	24683(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY mediated|nmod|receptors action|acl|mediated independent|nmod|action Action|dep|independent Action|nmod|END_ENTITY	Action of prolactin in regressing prostate : independent of action mediated by androgen receptors .
6773818	0	androgen	27,35	prolactin	14,23	androgen	prolactin	CHEBI:50113	5617	Chemical	Gene	response|compound|START_ENTITY effect|nmod|response effect|nmod|END_ENTITY	The effect of prolactin on androgen response to human chorionic gonadotropin in normal men .
12575398	0	androgen	77,85	proopiomelanocortin	42,61	androgen	proopiomelanocortin	CHEBI:50113	24664(Tax:10116)	Chemical	Gene	rats|compound|START_ENTITY levels|nmod|rats levels|compound|END_ENTITY	-LSB- Effect of tiangui recipe on hypothalamic proopiomelanocortin mRNA levels in androgen sterilized rats -RSB- .
1407381	0	androgen	10,18	proopiomelanocortin	47,66	androgen	proopiomelanocortin	CHEBI:50113	24664(Tax:10116)	Chemical	Gene	alter|nsubj|START_ENTITY alter|dobj|levels levels|compound|END_ENTITY	Exogenous androgen does not alter hypothalamic proopiomelanocortin gene transcript levels in the sexually immature male rat .
7898311	0	androgen	34,42	proopiomelanocortin	62,81	androgen	proopiomelanocortin	CHEBI:50113	24664(Tax:10116)	Chemical	Gene	START_ENTITY|acl|induced induced|nmod|expression expression|compound|END_ENTITY	Aromatization is not required for androgen induced changes in proopiomelanocortin gene expression in the hypothalamus .
10487704	0	androgen	62,70	prostate-specific_antigen	98,123	androgen	prostate-specific antigen	CHEBI:50113	354	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Breast tissues in transsexual women -- a nonprostatic source of androgen up-regulated production of prostate-specific_antigen .
11000519	0	androgen	45,53	prostate-specific_antigen	72,97	androgen	prostate-specific antigen	CHEBI:50113	354	Chemical	Gene	regulation|compound|START_ENTITY role|nmod|regulation role|nmod|enhancer enhancer|amod|END_ENTITY	A role for GATA transcription factors in the androgen regulation of the prostate-specific_antigen gene enhancer .
1371717	0	androgen	49,57	prostate-specific_antigen	71,96	androgen	prostate-specific antigen	CHEBI:50113	354	Chemical	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	Tumor-promoting phorbol_ester down-regulates the androgen induction of prostate-specific_antigen in a human prostatic_adenocarcinoma cell line .
15702224	0	androgen	97,105	prostate-specific_antigen	29,54	androgen	prostate-specific antigen	CHEBI:50113	354	Chemical	Gene	blockage|compound|START_ENTITY undergoing|dobj|blockage importance|acl|undergoing importance|nmod|END_ENTITY	The prognostic importance of prostate-specific_antigen in monitoring patients undergoing maximum androgen blockage for metastatic prostate_cancer .
15752879	0	androgen	69,77	prostate-specific_antigen	18,43	androgen	prostate-specific antigen	CHEBI:50113	354	Chemical	Gene	deprivation|compound|START_ENTITY deprivation|nsubj|warrants warrants|amod|END_ENTITY	What pretreatment prostate-specific_antigen level warrants long-term androgen deprivation ?
16363653	0	androgen	93,101	prostate-specific_antigen	26,51	androgen	prostate-specific antigen	CHEBI:50113	354	Chemical	Gene	withdrawal|nmod|START_ENTITY withdrawal|compound|END_ENTITY	-LSB- Correlation of change in prostate-specific_antigen and testosterone following withdrawal of androgen ablation after combination of radiation and hormone therapy -RSB- .
16413696	0	androgen	59,67	prostate-specific_antigen	7,32	androgen	prostate-specific antigen	CHEBI:50113	354	Chemical	Gene	therapy|compound|START_ENTITY values|nmod|therapy values|amod|END_ENTITY	Rising prostate-specific_antigen values during neoadjuvant androgen deprivation therapy : The importance of monitoring .
16879443	0	androgen	25,33	prostate-specific_antigen	91,116	androgen	prostate-specific antigen	CHEBI:50113	354	Chemical	Gene	deprivation|compound|START_ENTITY prevalence|nmod|deprivation prevalence|nmod|advent advent|nmod|testing testing|amod|END_ENTITY	The rising prevalence of androgen deprivation among older American men since the advent of prostate-specific_antigen testing : a population-based cohort study .
16943536	0	androgen	10,18	prostate-specific_antigen	159,184	androgen	prostate-specific antigen	CHEBI:50113	354	Chemical	Gene	radiation_therapy|compound|START_ENTITY radiation_therapy|nmod|prostate_cancer prostate_cancer|acl|increasing increasing|dobj|level level|amod|END_ENTITY	Six-month androgen suppression plus radiation_therapy compared with radiation_therapy alone for men with prostate_cancer and a rapidly increasing pretreatment prostate-specific_antigen level .
17070363	0	androgen	130,138	prostate-specific_antigen	11,36	androgen	prostate-specific antigen	CHEBI:50113	354	Chemical	Gene	suppression|compound|START_ENTITY predictor|nmod|suppression expression|dep|predictor expression|amod|END_ENTITY	Persistent prostate-specific_antigen expression after neoadjuvant androgen depletion : an early predictor of relapse or incomplete androgen suppression .
17070363	0	androgen	66,74	prostate-specific_antigen	11,36	androgen	prostate-specific antigen	CHEBI:50113	354	Chemical	Gene	depletion|compound|START_ENTITY expression|nmod|depletion expression|amod|END_ENTITY	Persistent prostate-specific_antigen expression after neoadjuvant androgen depletion : an early predictor of relapse or incomplete androgen suppression .
17094454	0	androgen	120,128	prostate-specific_antigen	57,82	androgen	prostate-specific antigen	CHEBI:50113	354	Chemical	Gene	response|acl|START_ENTITY element|nmod|response element|dobj|1 1|nmod|correlates correlates|amod|END_ENTITY	A G/A polymorphism in the androgen response element 1 of prostate-specific_antigen gene correlates with the response to androgen deprivation therapy in Japanese population .
17094454	0	androgen	26,34	prostate-specific_antigen	57,82	androgen	prostate-specific antigen	CHEBI:50113	354	Chemical	Gene	response|compound|START_ENTITY polymorphism|nmod|response element|nsubj|polymorphism element|dobj|1 1|nmod|correlates correlates|amod|END_ENTITY	A G/A polymorphism in the androgen response element 1 of prostate-specific_antigen gene correlates with the response to androgen deprivation therapy in Japanese population .
17135641	0	androgen	38,46	prostate-specific_antigen	72,97	androgen	prostate-specific antigen	CHEBI:50113	354	Chemical	Gene	deprivation|compound|START_ENTITY deprivation|nmod|men men|nmod|progression progression|amod|END_ENTITY	Docetaxel , estramustine , and 15-month androgen deprivation for men with prostate-specific_antigen progression after definitive local therapy for prostate_cancer .
1724287	0	androgen	73,81	prostate-specific_antigen	20,45	androgen	prostate-specific antigen	CHEBI:50113	354	Chemical	Gene	responsive|nmod:npmod|START_ENTITY element|amod|responsive contains|dobj|element contains|nsubj|promoter promoter|nmod|gene gene|amod|END_ENTITY	The promoter of the prostate-specific_antigen gene contains a functional androgen responsive element .
17265527	0	androgen	104,112	prostate-specific_antigen	150,175	androgen	prostate-specific antigen	CHEBI:50113	354	Chemical	Gene	suppression|compound|START_ENTITY suppression|nmod|men men|nmod|evidence evidence|nmod|recurrence recurrence|amod|END_ENTITY	Locally advanced prostate_cancer -- biochemical results from a prospective phase II study of intermittent androgen suppression for men with evidence of prostate-specific_antigen recurrence after radiotherapy .
17340594	0	androgen	72,80	prostate-specific_antigen	32,57	androgen	prostate-specific antigen	CHEBI:50113	354	Chemical	Gene	suppression|compound|START_ENTITY Influence|nmod|suppression Influence|nmod|index index|nmod|failure failure|amod|END_ENTITY	Influence of body mass index on prostate-specific_antigen failure after androgen suppression and radiation therapy for localized_prostate_cancer .
17430253	0	androgen	155,163	prostate-specific_antigen	103,128	androgen	prostate-specific antigen	CHEBI:50113	354	Chemical	Gene	therapy|compound|START_ENTITY trend|nmod|therapy trend|amod|END_ENTITY	Prostate-specific_antigen half-life and pretreatment prostate-specific_antigen : crucial predictors for prostate-specific_antigen trend in delayed-combined androgen blockade therapy .
17441890	0	androgen	55,63	prostate-specific_antigen	3,28	androgen	prostate-specific antigen	CHEBI:50113	354	Chemical	Gene	excess|compound|START_ENTITY marker|nmod|excess marker|nsubj|END_ENTITY	Is prostate-specific_antigen a potential new marker of androgen excess in polycystic_ovary_syndrome ?
18242382	0	androgen	46,54	prostate-specific_antigen	8,33	androgen	prostate-specific antigen	CHEBI:50113	354	Chemical	Gene	therapy|compound|START_ENTITY nadir|nmod|therapy nadir|amod|END_ENTITY	Time to prostate-specific_antigen nadir after androgen suppression therapy for postoperative or postradiation PSA failure and risk of prostate_cancer-specific mortality .
18501083	0	androgen	98,106	prostate-specific_antigen	144,169	androgen	prostate-specific antigen	CHEBI:50113	354	Chemical	Gene	suppression|compound|START_ENTITY study|nmod|suppression Quality|nmod|study Quality|nmod|relapse relapse|amod|END_ENTITY	Quality of life , morbidity , and mortality results of a prospective phase II study of intermittent androgen suppression for men with evidence of prostate-specific_antigen relapse after radiation therapy for locally advanced prostate_cancer .
19602007	0	androgen	68,76	prostate-specific_antigen	27,52	androgen	prostate-specific antigen	CHEBI:50113	354	Chemical	Gene	blockade|compound|START_ENTITY achieve|nmod|blockade achieve|dobj|END_ENTITY	Failing to achieve a nadir prostate-specific_antigen after combined androgen blockade : predictive factors .
20687212	0	androgen	120,128	prostate-specific_antigen	6,31	androgen	prostate-specific antigen	CHEBI:50113	354	Chemical	Gene	therapy|compound|START_ENTITY receiving|dobj|therapy reflect|xcomp|receiving reflect|nsubj|levels levels|amod|END_ENTITY	Serum prostate-specific_antigen levels reflect the androgen milieu in patients with localized_prostate_cancer receiving androgen deprivation therapy : Tumor malignant potential and androgen milieu .
20687212	0	androgen	51,59	prostate-specific_antigen	6,31	androgen	prostate-specific antigen	CHEBI:50113	354	Chemical	Gene	receiving|nsubj|START_ENTITY reflect|xcomp|receiving reflect|nsubj|levels levels|amod|END_ENTITY	Serum prostate-specific_antigen levels reflect the androgen milieu in patients with localized_prostate_cancer receiving androgen deprivation therapy : Tumor malignant potential and androgen milieu .
22126137	0	androgen	166,174	prostate-specific_antigen	44,69	androgen	prostate-specific antigen	CHEBI:50113	354	Chemical	Gene	blockade|compound|START_ENTITY treated|nmod|blockade treated|nsubj|effect effect|nmod|changes changes|amod|END_ENTITY	Additive effect of zoledronic_acid on serum prostate-specific_antigen changes for hormone-sensitive prostate_cancer patients with bone metastasis treated by combined androgen blockade .
22438406	9	androgen	2133,2141	prostate-specific_antigen	2059,2084	androgen	prostate-specific antigen	CHEBI:50113	354	Chemical	Gene	blockade|compound|START_ENTITY failure|nmod|blockade failure|amod|END_ENTITY	Only a maintenance period following luteinizing hormone-releasing hormone agonist monotherapy -LRB- P < 0.005 ; hazard ratio , 16.8 -RRB- was revealed to be a significant independent risk factor for prostate-specific_antigen biochemical failure with total delayed-combined androgen blockade .
23060997	0	androgen	94,102	prostate-specific_antigen	44,69	androgen	prostate-specific antigen	CHEBI:50113	354	Chemical	Gene	blockade|compound|START_ENTITY nadir|nmod|blockade nadir|amod|END_ENTITY	Prostate-specific_antigen nadir and time to prostate-specific_antigen nadir following maximal androgen blockade independently predict prognosis in patients with metastatic_prostate_cancer .
24522405	0	androgen	84,92	prostate-specific_antigen	6,31	androgen	prostate-specific antigen	CHEBI:50113	354	Chemical	Gene	therapy|compound|START_ENTITY nadir|advcl|therapy nadir|nsubj|Nadir Nadir|dep|level level|amod|END_ENTITY	Nadir prostate-specific_antigen -LRB- PSA -RRB- level and time to PSA nadir following primary androgen deprivation therapy as independent prognostic factors in a Japanese large-scale prospective cohort study -LRB- J-CaP -RRB- .
2467015	0	androgen	28,36	prostate-specific_antigen	58,83	androgen	prostate-specific antigen	CHEBI:50113	354	Chemical	Gene	deprivation|compound|START_ENTITY deprivation|nmod|levels levels|amod|END_ENTITY	The influence of reversible androgen deprivation on serum prostate-specific_antigen levels in men with benign_prostatic_hyperplasia .
26641067	0	androgen	66,74	prostate-specific_antigen	26,51	androgen	prostate-specific antigen	CHEBI:50113	354	Chemical	Gene	therapy|compound|START_ENTITY prolong|nmod|therapy prolong|dobj|decline decline|amod|END_ENTITY	Fibroblasts prolong serum prostate-specific_antigen decline after androgen deprivation therapy in prostate_cancer .
7508788	0	androgen	16,24	prostate-specific_antigen	95,120	androgen	prostate-specific antigen	CHEBI:50113	354	Chemical	Gene	Significance|nmod|START_ENTITY deprivation|nsubj|Significance deprivation|nmod|END_ENTITY	Significance of androgen deprivation prior to radical prostatectomy , with special reference to prostate-specific_antigen .
8626436	0	androgen	4,12	prostate-specific_antigen	85,110	androgen	prostate-specific antigen	CHEBI:50113	354	Chemical	Gene	regions|compound|START_ENTITY cooperate|nsubj|regions cooperate|nmod|hormone hormone|acl|regulated regulated|dobj|activity activity|nmod|promoter promoter|amod|END_ENTITY	Two androgen response regions cooperate in steroid hormone regulated activity of the prostate-specific_antigen promoter .
9013762	0	androgen	3,11	prostate-specific_antigen	121,146	androgen	prostate-specific antigen	CHEBI:50113	354	Chemical	Gene	element|amod|START_ENTITY essential|nsubj|element essential|nmod|activity activity|nmod|promoter promoter|amod|END_ENTITY	An androgen response element in a far upstream enhancer region is essential for high , androgen-regulated activity of the prostate-specific_antigen promoter .
9070893	0	androgen	22,30	prostate-specific_antigen	96,121	androgen	prostate-specific antigen	CHEBI:50113	354	Chemical	Gene	responsive|nmod:npmod|START_ENTITY element|amod|responsive element|nmod|region region|nmod|gene gene|amod|END_ENTITY	Defining a functional androgen responsive element in the 5 ' far upstream flanking region of the prostate-specific_antigen gene .
9519418	0	androgen	44,52	prostate-specific_antigen	12,37	androgen	prostate-specific antigen	CHEBI:50113	354	Chemical	Gene	withdrawal|compound|START_ENTITY Response|nmod|withdrawal Response|nmod|END_ENTITY	Response of prostate-specific_antigen after androgen withdrawal and prognosis in men with metastatic prostate_cancer .
9933071	0	androgen	49,57	prostate-specific_antigen	17,42	androgen	prostate-specific antigen	CHEBI:50113	354	Chemical	Gene	replacement|compound|START_ENTITY rise|nmod|replacement rise|nmod|END_ENTITY	Dramatic rise in prostate-specific_antigen after androgen replacement in a hypogonadal man with occult adenocarcinoma_of_the_prostate .
18423746	0	androgen	46,54	prostate_specific_antigen	10,35	androgen	prostate specific antigen	CHEBI:50113	354	Chemical	Gene	stimulation|compound|START_ENTITY END_ENTITY|nmod|stimulation	Change in prostate_specific_antigen following androgen stimulation is an independent predictor of prostate_cancer diagnosis .
11248024	0	androgen	50,58	transforming_growth_factor-beta	5,36	androgen	transforming growth factor-beta	CHEBI:50113	7040	Chemical	Gene	signaling|xcomp|START_ENTITY END_ENTITY|acl|signaling	From transforming_growth_factor-beta signaling to androgen action : identification of Smad3 as an androgen_receptor coregulator in prostate_cancer cells .
11176459	0	androgen	157,165	vascular_endothelial_growth_factor	195,229	androgen	vascular endothelial growth factor	CHEBI:50113	7422	Chemical	Gene	destabilization|amod|START_ENTITY destabilization|nmod|transcripts transcripts|compound|END_ENTITY	Vascular_endothelial_growth_factor expression and tumor angiogenesis are regulated by androgens in hormone responsive human prostate_carcinoma : evidence for androgen dependent destabilization of vascular_endothelial_growth_factor transcripts .
17113911	0	androgen	92,100	vascular_endothelial_growth_factor	54,88	androgen	vascular endothelial growth factor	CHEBI:50113	83785(Tax:10116)	Chemical	Gene	regulation|compound|START_ENTITY Participation|nmod|regulation Participation|nmod|END_ENTITY	Participation of adrenomedullin and its relation with vascular_endothelial_growth_factor in androgen regulation of prostatic blood flow in vivo .
21458034	0	androgen	11,19	vascular_endothelial_growth_factor	41,75	androgen	vascular endothelial growth factor	CHEBI:50113	83785(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of androgen on the expression of vascular_endothelial_growth_factor in the penile corpus cavernosum .
9067270	0	androgen	58,66	vascular_endothelial_growth_factor	104,138	androgen	vascular endothelial growth factor	CHEBI:50113	7422	Chemical	Gene	ablation|compound|START_ENTITY linomide|nmod|ablation ability|nmod|linomide Potentiation|nmod|ability involves|nsubj|Potentiation involves|dobj|down-regulation down-regulation|nmod|END_ENTITY	Potentiation of the antiangiogenic ability of linomide by androgen ablation involves down-regulation of vascular_endothelial_growth_factor in human androgen-responsive prostatic_cancers .
10886097	0	androgen	11,19	vasoactive_intestinal_polypeptide	53,86	androgen	vasoactive intestinal polypeptide	CHEBI:50113	117064(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of androgen and ageing on gene expression of vasoactive_intestinal_polypeptide in rat corpus cavernosum .
11006085	0	androgens	79,88	15-hydroxyprostaglandin_dehydrogenase	27,64	androgens	15-hydroxyprostaglandin dehydrogenase	MESH:D000728	3248	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Induction of NAD -LRB- + -RRB- - linked 15-hydroxyprostaglandin_dehydrogenase expression by androgens in human prostate_cancer cells .
6223181	0	androgens	92,101	17_beta-hydroxysteroid_dehydrogenase	14,50	androgens	17 beta-hydroxysteroid dehydrogenase	MESH:D000728	51478	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activity activity|amod|END_ENTITY	Inhibition of 17_beta-hydroxysteroid_dehydrogenase activity in human endometrium by adrenal androgens .
6310248	0	androgens	142,151	17_beta-hydroxysteroid_dehydrogenase	34,70	androgens	17 beta-hydroxysteroid dehydrogenase	MESH:D000728	51478	Chemical	Gene	defect|nmod|START_ENTITY history|nmod|defect studies|nmod|history pseudohermaphroditism|dep|studies pseudohermaphroditism|amod|due due|nmod|deficiency deficiency|amod|END_ENTITY	Male pseudohermaphroditism due to 17_beta-hydroxysteroid_dehydrogenase deficiency : studies on the natural history of the defect and effect of androgens on gender role .
1699965	0	androgens	72,81	5_alpha-reductase	25,42	androgens	5 alpha-reductase	MESH:D000728	6715	Chemical	Gene	inhibitor|nmod|START_ENTITY inhibitor|amod|END_ENTITY	Effect of finasteride , a 5_alpha-reductase inhibitor on prostate tissue androgens and prostate-specific_antigen .
11077425	0	androgens	120,129	Androgen_receptor	0,17	androgens	Androgen receptor	MESH:D000728	367	Chemical	Gene	effects|nmod|START_ENTITY regulation|dep|effects regulation|amod|END_ENTITY	Androgen_receptor mRNA regulation in adult male and female hamster facial_motoneurons : effects of axotomy and exogenous androgens .
9889303	0	androgens	109,118	Androgen_receptor	0,17	androgens	Androgen receptor	MESH:D000728	11835(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY immunoreactivity|dep|effect immunoreactivity|amod|END_ENTITY	Androgen_receptor immunoreactivity in specific neural regions in normal and hypogonadal male mice : effect of androgens .
25776650	0	androgens	29,38	CYB5A	0,5	androgens	CYB5A	MESH:D000728	1528	Chemical	Gene	START_ENTITY|nsubj|increases increases|compound|END_ENTITY	CYB5A polymorphism increases androgens and reduces risk of rheumatoid_arthritis in women .
12690088	0	androgens	37,46	CYP19	4,9	androgens	CYP19	MESH:D000728	1588	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	The CYP19 gene and associations with androgens and abdominal_obesity in premenopausal women .
17636171	0	androgens	55,64	Claudin-11	0,10	androgens	Claudin-11	MESH:D000728	84588(Tax:10116)	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|compound|END_ENTITY	Claudin-11 expression and localisation is regulated by androgens in rat Sertoli cells in vitro .
16837735	0	androgens	33,42	Cres	46,50	androgens	Cres	MESH:D000728	13012(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mRNA mRNA|compound|END_ENTITY	Differential effects of GnRH and androgens on Cres mRNA and protein in male mouse anterior pituitary gonadotropes .
18726983	0	androgens	32,41	FLIP	13,17	androgens	FLIP	MESH:D000728	8837	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Induction of FLIP expression by androgens protects prostate_cancer cells from TRAIL-mediated apoptosis .
11018752	0	androgens	8,17	HC11	93,97	androgens	HC11	MESH:D000728	15142(Tax:10090)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of androgens in proliferation and differentiation of mouse mammary epithelial cell line HC11 .
19917249	0	androgens	66,75	HOXB13	24,30	androgens	HOXB13	MESH:D000728	10481	Chemical	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	The homeodomain protein HOXB13 regulates the cellular response to androgens .
388247	1	androgens	48,57	LH-RH	120,125	androgens	LH-RH	MESH:D000728	25194(Tax:10116)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of androgens on the pituitary response to single or multiple injections of LH-RH .
6437958	0	androgens	27,36	LHRH	40,44	androgens	LHRH	MESH:D000728	2796	Chemical	Gene	START_ENTITY|nmod|responses responses|compound|END_ENTITY	Effect of non aromatizable androgens on LHRH and TRH responses in primary testicular_failure .
11259762	0	androgens	62,71	N-cadherin	0,10	androgens	N-cadherin	MESH:D000728	83501(Tax:10116)	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	N-cadherin expression in motoneurons is directly regulated by androgens : a genetic mosaic analysis in rats .
17660883	0	androgens	21,30	PSA	71,74	androgens	PSA	MESH:D000728	354	Chemical	Gene	Correlation|nmod|START_ENTITY END_ENTITY|nsubj|Correlation	Correlation of serum androgens and pituitary hormone levels with serum PSA less than 2.5 ng/ml .
6233834	0	androgens	47,56	Prolactin	0,9	androgens	Prolactin	MESH:D000728	5617	Chemical	Gene	roles|nmod|START_ENTITY END_ENTITY|dep|roles	Prolactin in hirsute women : possible roles for androgens in suppressing basal levels , and for oestrogens in enhancing TRH-induced responses .
18801930	0	androgens	10,19	S-22	84,88	androgens	S-22	MESH:D000728	379094(Tax:8355)	Chemical	Gene	START_ENTITY|appos|modulator modulator|appos|END_ENTITY	Steroidal androgens and nonsteroidal , tissue-selective androgen_receptor modulator , S-22 , regulate androgen_receptor function through distinct genomic and nongenomic signaling pathways .
21432868	0	androgens	41,50	STIM1	19,24	androgens	STIM1	MESH:D000728	6786	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	The calcium sensor STIM1 is regulated by androgens in prostate stromal cells .
11564721	0	androgens	32,41	VCSA1	53,58	androgens	VCSA1	MESH:D000728	24867(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	The transcriptional response to androgens of the rat VCSA1 gene is amplified by both binary and graded mechanisms .
11176459	0	androgens	86,95	Vascular_endothelial_growth_factor	0,34	androgens	Vascular endothelial growth factor	MESH:D000728	7422	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	Vascular_endothelial_growth_factor expression and tumor angiogenesis are regulated by androgens in hormone responsive human prostate_carcinoma : evidence for androgen dependent destabilization of vascular_endothelial_growth_factor transcripts .
23087175	0	androgens	47,56	Wnt_inhibitory_factor_1	0,23	androgens	Wnt inhibitory factor 1	MESH:D000728	24117(Tax:10090)	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Wnt_inhibitory_factor_1 -LRB- Wif1 -RRB- is regulated by androgens and enhances androgen-dependent prostate development .
10913941	0	androgens	13,22	androgen_receptor	34,51	androgens	androgen receptor	MESH:D000728	367	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of androgens and age on androgen_receptor and 5 alpha-reductase II transcription .
11694337	0	androgens	167,176	androgen_receptor	60,77	androgens	androgen receptor	MESH:D000728	367	Chemical	Gene	presence|nmod|START_ENTITY studying|nmod|presence studying|dobj|activity activity|compound|END_ENTITY	Human prostatic cell line PNT1A , a useful tool for studying androgen_receptor transcriptional activity and its differential subnuclear localization in the presence of androgens and antiandrogens .
12793900	0	androgens	12,21	androgen_receptor	47,64	androgens	androgen receptor	MESH:D000728	367	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of androgens and polymorphisms in the androgen_receptor in the epidemiology of breast_cancer .
16598378	0	androgens	79,88	androgen_receptor	158,175	androgens	androgen receptor	MESH:D000728	11835(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY activation|nmod|effects impact|nmod|activation impact|dep|study study|nmod|model model|compound|END_ENTITY	Relative impact of androgen and estrogen receptor activation in the effects of androgens on trabecular and cortical bone in growing male mice : a study in the androgen_receptor knockout mouse model .
16964284	0	androgens	39,48	androgen_receptor	60,77	androgens	androgen receptor	MESH:D000728	367	Chemical	Gene	downregulated|nmod|START_ENTITY protein|acl|downregulated Prohibitin|appos|protein represses|nsubj|Prohibitin represses|dobj|activity activity|compound|END_ENTITY	Prohibitin , a protein downregulated by androgens , represses androgen_receptor activity .
17086931	0	androgens	71,80	androgen_receptor	10,27	androgens	androgen receptor	MESH:D000728	367	Chemical	Gene	pursuit|nmod|START_ENTITY modulators|nmod|pursuit modulators|compound|END_ENTITY	Selective androgen_receptor modulators : in pursuit of tissue-selective androgens .
17326011	0	androgens	103,112	androgen_receptor	18,35	androgens	androgen receptor	MESH:D000728	367	Chemical	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of the androgen_receptor by antisense oligonucleotides regulates the biological activity of androgens in SZ95 sebocytes .
17326012	0	androgens	18,27	androgen_receptor	88,105	androgens	androgen receptor	MESH:D000728	367	Chemical	Gene	Responsiveness|nmod|START_ENTITY Responsiveness|nmod|oligonucleotides oligonucleotides|nmod|END_ENTITY	Responsiveness to androgens and effectiveness of antisense oligonucleotides against the androgen_receptor on human epidermal keratinocytes is dependent on the age of the donor and the location of cell origin .
17331889	0	androgens	33,42	androgen_receptor	57,74	androgens	androgen receptor	MESH:D000728	367	Chemical	Gene	START_ENTITY|nmod|modulators modulators|compound|END_ENTITY	Expanding the therapeutic use of androgens via selective androgen_receptor modulators -LRB- SARMs -RRB- .
17433535	0	androgens	95,104	androgen_receptor	59,76	androgens	androgen receptor	MESH:D000728	367	Chemical	Gene	absence|nmod|START_ENTITY END_ENTITY|nmod|absence	14-3-3_sigma increases the transcriptional activity of the androgen_receptor in the absence of androgens .
18218096	0	androgens	134,143	androgen_receptor	4,21	androgens	androgen receptor	MESH:D000728	367	Chemical	Gene	levels|nmod|START_ENTITY signal|nmod|levels signal|nsubj|END_ENTITY	The androgen_receptor can signal through Wnt/beta-Catenin in prostate_cancer cells as an adaptation mechanism to castration levels of androgens .
18801930	0	androgens	10,19	androgen_receptor	55,72	androgens	androgen receptor	MESH:D000728	24208(Tax:10116)	Chemical	Gene	START_ENTITY|appos|modulator modulator|compound|END_ENTITY	Steroidal androgens and nonsteroidal , tissue-selective androgen_receptor modulator , S-22 , regulate androgen_receptor function through distinct genomic and nongenomic signaling pathways .
18801930	0	androgens	10,19	androgen_receptor	99,116	androgens	androgen receptor	MESH:D000728	24208(Tax:10116)	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|function function|compound|END_ENTITY	Steroidal androgens and nonsteroidal , tissue-selective androgen_receptor modulator , S-22 , regulate androgen_receptor function through distinct genomic and nongenomic signaling pathways .
18948405	0	androgens	42,51	androgen_receptor	72,89	androgens	androgen receptor	MESH:D000728	11835(Tax:10090)	Chemical	Gene	differentiation|nmod|START_ENTITY Regulation|nmod|differentiation Regulation|dep|talk talk|nmod|END_ENTITY	Regulation of myogenic differentiation by androgens : cross talk between androgen_receptor / beta-catenin and follistatin/transforming growth factor-beta signaling pathways .
19808968	0	androgens	92,101	androgen_receptor	24,41	androgens	androgen receptor	MESH:D000728	367	Chemical	Gene	levels|nmod|START_ENTITY sensitizes|nmod|levels sensitizes|nsubj|expression expression|nmod|END_ENTITY	Increased expression of androgen_receptor sensitizes prostate_cancer cells to low levels of androgens .
2177837	0	androgens	67,76	androgen_receptor	14,31	androgens	androgen receptor	MESH:D000728	24208(Tax:10116)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|protein protein|compound|END_ENTITY	Regulation of androgen_receptor protein and mRNA concentrations by androgens in rat ventral prostate and seminal vesicles and in human hepatoma cells .
22179832	0	androgens	160,169	androgen_receptor	120,137	androgens	androgen receptor	MESH:D000728	367	Chemical	Gene	increasing|nmod|START_ENTITY increasing|dobj|activation activation|compound|END_ENTITY	Reducing prohibitin increases histone acetylation , and promotes androgen independence in prostate_tumours by increasing androgen_receptor activation by adrenal androgens .
22332118	0	androgens	110,119	androgen_receptor	32,49	androgens	androgen receptor	MESH:D000728	11835(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY study|dobj|effects development|acl|study development|nmod|model model|compound|END_ENTITY	The development of an inducible androgen_receptor knockout model in mouse to study the postmeiotic effects of androgens on germ cell development .
24903497	0	androgens	56,65	androgen_receptor	93,110	androgens	androgen receptor	MESH:D000728	11835(Tax:10090)	Chemical	Gene	formation|nmod|START_ENTITY Modulation|nmod|formation independent|nsubj|Modulation independent|nmod|END_ENTITY	Modulation of neointimal lesion formation by endogenous androgens is independent of vascular androgen_receptor .
6708513	0	androgens	24,33	androgen_receptor	71,88	androgens	androgen receptor	MESH:D000728	367	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|concentrations concentrations|compound|END_ENTITY	Differential effects of androgens and glucocorticoids on regulation of androgen_receptor concentrations and cell growth .
7155992	0	androgens	24,33	androgen_receptor	110,127	androgens	androgen receptor	MESH:D000728	24208(Tax:10116)	Chemical	Gene	action|nmod|START_ENTITY Mechanisms|nmod|action Mechanisms|dep|effects effects|nmod|antiandrogens antiandrogens|nmod|translocation translocation|nmod|END_ENTITY	Mechanisms of action of androgens and antiandrogens : effects of antiandrogens on translocation of cytoplasmic androgen_receptor and nuclear abundance of dihydrotestosterone .
7460859	0	androgens	93,102	androgen_receptor	27,44	androgens	androgen receptor	MESH:D000728	24208(Tax:10116)	Chemical	Gene	administration|nmod|START_ENTITY ventral|nmod|administration ventral|nsubj|Changes Changes|nmod|END_ENTITY	Changes in the cytoplasmic androgen_receptor of rat ventral prostate after administration of androgens , antiandrogens and anabolic_steroids .
7625734	0	androgens	11,20	androgen_receptor	66,83	androgens	androgen receptor	MESH:D000728	367	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|conformation conformation|nmod|END_ENTITY	Effects of androgens and antiandrogens on the conformation of the androgen_receptor .
8136298	0	androgens	14,23	androgen_receptor	89,106	androgens	androgen receptor	MESH:D000728	24208(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|localization localization|nmod|END_ENTITY	The effect of androgens and antiandrogens on the immunohistochemical localization of the androgen_receptor in accessory reproductive organs of male rats .
8145761	0	androgens	99,108	androgen_receptor	7,24	androgens	androgen receptor	MESH:D000728	367	Chemical	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	Mutant androgen_receptor detected in an advanced-stage prostatic_carcinoma is activated by adrenal androgens and progesterone .
8674832	0	androgens	40,49	androgen_receptor	53,70	androgens	androgen receptor	MESH:D000728	24208(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Developmental pattern and regulation by androgens of androgen_receptor expression in the urogenital tract of the rat .
8883929	0	androgens	137,146	androgen_receptor	14,31	androgens	androgen receptor	MESH:D000728	367	Chemical	Gene	effects|nmod|START_ENTITY Regulation|dep|effects Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of androgen_receptor mRNA expression in hamster facial motoneurons : differential effects of non-aromatizable and aromatizable androgens .
9878277	0	androgens	53,62	androgen_receptor	76,93	androgens	androgen receptor	MESH:D000728	24208(Tax:10116)	Chemical	Gene	sexual_receptivity|nmod|START_ENTITY Inhibition|nmod|sexual_receptivity Inhibition|dep|role role|nmod|END_ENTITY	Inhibition of estrogen-induced sexual_receptivity by androgens : role of the androgen_receptor .
6241882	0	androgens	49,58	angiotensin_II	10,24	androgens	angiotensin II	MESH:D000728	183	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of angiotensin_II on secretion of adrenal androgens .
6296191	0	androgens	78,87	angiotensin_II	11,25	androgens	angiotensin II	MESH:D000728	183	Chemical	Gene	concentrations|nmod|START_ENTITY increases|nmod|concentrations stimulate|dobj|increases Failure|acl|stimulate Failure|nmod|END_ENTITY	Failure of angiotensin_II to stimulate increases in concentrations of adrenal androgens , 17-hydroxyprogesterone , or adrenocorticotropin in congenital_21-hydroxylase_deficiency .
7873450	0	androgens	78,87	c-fos	14,19	androgens	c-fos	MESH:D000728	2353	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of c-fos expression and TGF-beta production by gonadal and adrenal androgens in normal human osteoblastic cells .
11330645	0	androgens	41,50	caltrin	14,21	androgens	caltrin	MESH:D000728	56872(Tax:10090)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of caltrin mRNA expression by androgens in the murine prostate .
17148459	0	androgens	57,66	clusterin	27,36	androgens	clusterin	MESH:D000728	24854(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of clusterin and its isoforms by androgens in prostate cells .
17581945	0	androgens	19,28	dopa_decarboxylase	109,127	androgens	dopa decarboxylase	MESH:D000728	1644	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nsubj|effect	Biphasic effect of androgens on prostate_cancer cells and its correlation with androgen_receptor coactivator dopa_decarboxylase .
9806289	0	androgens	50,59	epidermal_growth_factor_receptor	14,46	androgens	epidermal growth factor receptor	MESH:D000728	1956	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of epidermal_growth_factor_receptor by androgens in human endometrial cells in culture .
9328363	0	androgens	91,100	erythropoietin	46,60	androgens	erythropoietin	MESH:D000728	2056	Chemical	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	A 6-month study of low-dose recombinant human erythropoietin alone and in combination with androgens for the treatment of anemia in chronic_hemodialysis patients .
2338225	0	androgens	13,22	growth_hormone	51,65	androgens	growth hormone	MESH:D000728	378781(Tax:9031)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of androgens on plasma concentrations of growth_hormone in growing castrated and intact chickens .
2493123	0	androgens	108,117	growth_hormone	121,135	androgens	growth hormone	MESH:D000728	2688	Chemical	Gene	START_ENTITY|nmod|release release|amod|END_ENTITY	Androgen-dependent somatotroph function in a hypogonadal adolescent male : evidence for control of exogenous androgens on growth_hormone release .
3940264	0	androgens	14,23	growth_hormone	96,110	androgens	growth hormone	MESH:D000728	2688	Chemical	Gene	effect|nmod|START_ENTITY mean|nsubj|effect mean|dobj|concentration concentration|nmod|END_ENTITY	The effect of androgens on the pulsatile release and the twenty-four-hour mean concentration of growth_hormone in peripubertal males .
6237972	0	androgens	42,51	growth_hormone	16,30	androgens	growth hormone	MESH:D000728	2688	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of human growth_hormone on adrenal androgens in children with growth_hormone deficiency .
6237972	0	androgens	42,51	growth_hormone	69,83	androgens	growth hormone	MESH:D000728	2688	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|children children|nmod|deficiency deficiency|amod|END_ENTITY	Effect of human growth_hormone on adrenal androgens in children with growth_hormone deficiency .
6378433	0	androgens	10,19	growth_hormone	86,100	androgens	growth hormone	MESH:D000728	2688	Chemical	Gene	Effect|nmod|START_ENTITY somatomedin-C/insulin-like|nsubj|Effect somatomedin-C/insulin-like|xcomp|END_ENTITY	Effect of androgens on plasma somatomedin-C/insulin-like growth factor I responses to growth_hormone .
10334972	3	androgens	532,541	insulin	578,585	androgens	insulin	MESH:D000728	3630	Chemical	Gene	levels|nmod|START_ENTITY levels|acl:relcl|linked linked|nmod|polymorphism polymorphism|compound|END_ENTITY	Premature male pattern baldness may be the male phenotype of familial_polycystic_ovary_syndrome , a condition characterized by high levels of androgens and insulin that has been linked to insulin gene polymorphism .
16989707	0	androgens	16,25	insulin	29,36	androgens	insulin	MESH:D000728	3630	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	Relationship of androgens to insulin resistance and chronic_inflammation in morbidly obese premenopausal women : studies before and after vertical banded gastroplasty .
18615851	0	androgens	11,20	insulin	24,31	androgens	insulin	MESH:D000728	3630	Chemical	Gene	START_ENTITY|nmod|action action|compound|END_ENTITY	Effects of androgens on insulin action in women : is androgen excess a component of female metabolic_syndrome ?
23315058	0	androgens	60,69	insulin	25,32	androgens	insulin	MESH:D000728	3630	Chemical	Gene	START_ENTITY|nsubj|Comparison Comparison|nmod|markers markers|nmod|resistance resistance|compound|END_ENTITY	Comparison of markers of insulin resistance and circulating androgens between women with polycystic_ovary_syndrome and women with metabolic_syndrome .
3084615	0	androgens	24,33	insulin	41,48	androgens	insulin	MESH:D000728	3630	Chemical	Gene	changes|nmod|START_ENTITY changes|nmod|withdrawal withdrawal|compound|END_ENTITY	Rapid changes in plasma androgens during insulin withdrawal in male_type_1 -LRB- insulin-dependent -RRB- diabetics .
7868804	0	androgens	45,54	insulin	88,95	androgens	insulin	MESH:D000728	3630	Chemical	Gene	Reduction|nmod|START_ENTITY alter|nsubj|Reduction alter|dobj|response response|compound|END_ENTITY	Reduction of endogenous , ovarian and adrenal androgens with ketoconazole does not alter insulin response in the polycystic_ovary_syndrome .
8027240	0	androgens	35,44	insulin	13,20	androgens	insulin	MESH:D000728	3630	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|resistance resistance|compound|END_ENTITY	Induction of insulin resistance by androgens and estrogens .
8370914	0	androgens	6,15	insulin	107,114	androgens	insulin	MESH:D000728	3630	Chemical	Gene	START_ENTITY|nmod|infusion infusion|compound|END_ENTITY	Serum androgens in hyperinsulinemic_Pima_Indian_and_obese Caucasian women and their response to short-term insulin infusion .
8548057	0	androgens	113,122	insulin	25,32	androgens	insulin	MESH:D000728	3630	Chemical	Gene	START_ENTITY|nsubj|changes changes|nmod|resistance resistance|compound|END_ENTITY	No changes of peripheral insulin resistance in polycystic_ovary_syndrome after long-term reduction of endogenous androgens with leuprolide .
8772557	0	androgens	117,126	insulin	134,141	androgens	insulin	MESH:D000728	3630	Chemical	Gene	START_ENTITY|xcomp|impair impair|dobj|action action|compound|END_ENTITY	The insulin resistance in women with hyperandrogenism is partially reversed by antiandrogen treatment : evidence that androgens impair insulin action in women .
8772557	0	androgens	117,126	insulin	4,11	androgens	insulin	MESH:D000728	3630	Chemical	Gene	evidence|acl:relcl|START_ENTITY treatment|dep|evidence reversed|nmod|treatment reversed|nsubjpass|resistance resistance|compound|END_ENTITY	The insulin resistance in women with hyperandrogenism is partially reversed by antiandrogen treatment : evidence that androgens impair insulin action in women .
9005061	0	androgens	74,83	insulin	32,39	androgens	insulin	MESH:D000728	3630	Chemical	Gene	relations|nmod|START_ENTITY -LSB-|nmod|relations -LSB-|dobj|mechanism mechanism|nmod|effect effect|nmod|END_ENTITY	-LSB- The mechanism of the effect of insulin on the interhormonal relations of androgens and glucocorticoids in the body -RSB- .
7534449	0	androgens	37,46	insulin-like_growth_factor_binding_protein-1	87,131	androgens	insulin-like growth factor binding protein-1	MESH:D000728	3484	Chemical	Gene	circulating|dobj|START_ENTITY circulating|nmod|END_ENTITY	The relationship between circulating androgens , obesity , and hyperinsulinemia on serum insulin-like_growth_factor_binding_protein-1 in the polycystic_ovarian_syndrome .
17918155	0	androgens	93,102	insulin-like_growth_factor_binding_protein-3	12,56	androgens	insulin-like growth factor binding protein-3	MESH:D000728	3486	Chemical	Gene	role|nmod|START_ENTITY role|nmod|actions actions|amod|END_ENTITY	The role of insulin-like_growth_factor_binding_protein-3 in the growth inhibitory actions of androgens in LNCaP human prostate_cancer cells .
3156143	0	androgens	16,25	myotonic_dystrophy	43,61	androgens	myotonic dystrophy	MESH:D000728	1760	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	Reduced adrenal androgens in patients with myotonic_dystrophy .
12153751	0	androgens	44,53	osteoprotegerin	14,29	androgens	osteoprotegerin	MESH:D000728	4982	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|production production|compound|END_ENTITY	Regulation of osteoprotegerin production by androgens and anti-androgens in human osteoblastic lineage cells .
2830552	0	androgens	10,19	pro-opiomelanocortin	36,56	androgens	pro-opiomelanocortin	MESH:D000728	24664(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of androgens on hypothalamic pro-opiomelanocortin .
3721057	0	androgens	38,47	progesterone_receptor	13,34	androgens	progesterone receptor	MESH:D000728	18667(Tax:10090)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of progesterone_receptor by androgens in the mouse uterus .
146573	0	androgens	8,17	prolactin	63,72	androgens	prolactin	MESH:D000728	5617	Chemical	Gene	marked|nsubj|START_ENTITY marked|dobj|elevation elevation|nmod|END_ENTITY	Adrenal androgens in patients with chronic marked elevation of prolactin .
521705	0	androgens	96,105	prolactin	6,15	androgens	prolactin	MESH:D000728	5617	Chemical	Gene	castrated|nmod|START_ENTITY castrated|nsubj|levels levels|compound|END_ENTITY	Serum prolactin levels in castrated rams at various times of the year and during treatment with androgens or oestrogen .
6227379	0	androgens	32,41	prolactin	13,22	androgens	prolactin	MESH:D000728	5617	Chemical	Gene	START_ENTITY|nsubj|Influence Influence|nmod|END_ENTITY	Influence of prolactin on serum androgens in normoprolactinaemic women .
7165125	0	androgens	26,35	prolactin	39,48	androgens	prolactin	MESH:D000728	24683(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of 5 alpha-reduced androgens on prolactin secretion .
929774	0	androgens	11,20	prolactin	28,37	androgens	prolactin	MESH:D000728	24683(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of androgens and/or prolactin on ventral prostate transplants .
955845	0	androgens	41,50	prolactin	10,19	androgens	prolactin	MESH:D000728	24683(Tax:10116)	Chemical	Gene	metabolism|nmod|START_ENTITY END_ENTITY|nmod|metabolism	Effect of prolactin on the metabolism of androgens by the rat ventral prostate gland in vitro .
22939842	0	androgens	88,97	vitamin_D_receptor	128,146	androgens	vitamin D receptor	MESH:D000728	7421	Chemical	Gene	START_ENTITY|nmod|cells cells|nmod|END_ENTITY	Regulation of CYP3A4 and CYP3A5 expression and modulation of `` intracrine '' metabolism of androgens in prostate cells by liganded vitamin_D_receptor .
17825862	0	andrographolide	53,68	CYP1A1	32,38	andrographolide	CYP1A1	MESH:C030419	13076(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Strong synergistic induction of CYP1A1 expression by andrographolide plus typical CYP1A inducers in mouse hepatocytes .
18086662	0	andrographolide	39,54	Erk	115,118	andrographolide	Erk	MESH:C030419	26413(Tax:10090)	Chemical	Gene	Suppression|nmod|START_ENTITY Suppression|nmod|END_ENTITY	Suppression of v-Src transformation by andrographolide via degradation of the v-Src protein and attenuation of the Erk signaling pathway .
19887051	0	andrographolide	112,127	NF-kappaB	14,23	andrographolide	NF-kappaB	MESH:C030419	18033(Tax:10090)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|expression expression|amod|END_ENTITY	Inhibition of NF-kappaB expression and allergen-induced airway_inflammation in a mouse allergic_asthma model by andrographolide .
21365364	0	andrographolide	77,92	cytochrome_P450	110,125	andrographolide	cytochrome P450	MESH:C030419	4051	Chemical	Gene	START_ENTITY|nmod|activities activities|amod|END_ENTITY	In vitro determination of the effect of Andrographis paniculata extracts and andrographolide on human hepatic cytochrome_P450 activities .
22244537	0	andrographolide	56,71	matrix_metalloproteinase-9	15,41	andrographolide	matrix metalloproteinase-9	MESH:C030419	4318	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Suppression of matrix_metalloproteinase-9 expression by andrographolide in human monocytic THP-1 cells via inhibition of NF-kB activation .
23615401	0	andrographolide	101,116	matrix_metalloproteinase-9	60,86	andrographolide	matrix metalloproteinase-9	MESH:C030419	4318	Chemical	Gene	cells|amod|START_ENTITY Induction|nmod|cells Induction|nmod|expression expression|amod|END_ENTITY	Induction of heme_oxygenase-1 and inhibition of TPA-induced matrix_metalloproteinase-9 expression by andrographolide in MCF-7 human breast_cancer cells .
12114525	0	androstane	82,92	CAR	103,106	androstane	CAR	MESH:C033936	9970	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Inhibitory cross-talk between estrogen receptor -LRB- ER -RRB- and constitutively activated androstane receptor -LRB- CAR -RRB- .
21821919	0	androstane	59,69	CAR	79,82	androstane	CAR	MESH:C033936	653108	Chemical	Gene	receptor|compound|START_ENTITY activating|dobj|receptor beverages|acl|activating Polyphenols|nmod|beverages END_ENTITY|nsubj|Polyphenols	Polyphenols in alcoholic beverages activating constitutive androstane receptor CAR .
11679585	1	androstane	92,102	glucocorticoid_receptor	51,74	androstane	glucocorticoid receptor	MESH:C033936	2908	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of glucocorticoid_receptor and constitutive androstane receptor .
15905360	0	androstane	99,109	vitamin_D_receptor	59,77	androstane	vitamin D receptor	MESH:C033936	7421	Chemical	Gene	START_ENTITY|nsubj|interactions interactions|nmod|END_ENTITY	Antagonist - and inverse agonist-driven interactions of the vitamin_D_receptor and the constitutive androstane receptor with corepressor protein .
21303972	0	androstanediol	69,83	androgen_receptor	18,35	androstanediol	androgen receptor	CHEBI:27727	367	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of the androgen_receptor by intratumoral bioconversion of androstanediol to dihydrotestosterone_in_prostate_cancer .
20720262	0	androstenedione	50,65	CYP17	17,22	androstenedione	CYP17	MESH:D000735	1586	Chemical	Gene	START_ENTITY|nsubj|expression expression|appos|END_ENTITY	17a-Hydroxylase -LRB- CYP17 -RRB- expression and subsequent androstenedione production in the human ovary .
6403394	0	androstenedione	15,30	LHRH	59,63	androstenedione	LHRH	MESH:D000735	25194(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	Stimulation of androstenedione and progesterone release by LHRH and LHRH agonist from isolated rat preovulatory follicles .
2340316	0	androstenedione	110,125	cytochrome_P-450	55,71	androstenedione	cytochrome P-450	MESH:D000735	25251(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY END_ENTITY|nmod|metabolism	-LSB- Evaluation of catalytic activity of multiple forms of cytochrome_P-450 in liver microsomes of Wistar_rats by androstenedione metabolism -RSB- .
4084542	0	androstenedione	125,140	cytochrome_P-450	64,80	androstenedione	cytochrome P-450	MESH:D000735	25251(Tax:10116)	Chemical	Gene	metabolism|nmod|START_ENTITY sites|dep|metabolism sites|nmod|hydroxylation hydroxylation|nmod|system system|amod|END_ENTITY	Multiple sites of steroid hydroxylation by the liver microsomal cytochrome_P-450 system : primary and secondary metabolism of androstenedione .
6446359	0	androstenedione	36,51	hCG	11,14	androstenedione	hCG	MESH:D000735	3342	Chemical	Gene	production|nmod|START_ENTITY END_ENTITY|nmod|production	-LSB- Effect of hCG on the production of androstenedione , testosterone and dihydrotestosterone by long term organ culture testicular tissue from hypophysectomized boars -RSB- .
16595701	0	androstenone	117,129	SULT2A1	44,51	androstenone	SULT2A1	CHEBI:37894	6822	Chemical	Gene	expression|nmod|START_ENTITY relationship|nmod|expression cloning|dep|relationship cloning|nmod|END_ENTITY	Molecular cloning and regulation of porcine SULT2A1 : relationship between SULT2A1 expression and sulfoconjugation of androstenone .
16595701	0	androstenone	117,129	SULT2A1	74,81	androstenone	SULT2A1	CHEBI:37894	6822	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Molecular cloning and regulation of porcine SULT2A1 : relationship between SULT2A1 expression and sulfoconjugation of androstenone .
8735595	0	androsterone	26,38	Growth_hormone	0,14	androsterone	Growth hormone	MESH:D000738	81668(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY stimulates|dobj|synthesis stimulates|nsubj|END_ENTITY	Growth_hormone stimulates androsterone synthesis by rat theca-interstitial cells .
6433897	0	androsterone	122,134	UDP-glucuronosyltransferase	75,102	androsterone	UDP-glucuronosyltransferase	MESH:D000738	24862(Tax:10116)	Chemical	Gene	activities|nmod|START_ENTITY activities|amod|END_ENTITY	Effects of steroid hormones and xenobiotics on the pubertal development of UDP-glucuronosyltransferase activities towards androsterone and 4-nitrophenol in Wistar_rats .
14573603	0	androsterone	12,24	dehydroepiandrosterone_sulfotransferase	64,103	androsterone	dehydroepiandrosterone sulfotransferase	MESH:D000738	6822	Chemical	Gene	START_ENTITY|nmod|substrate substrate|nmod|END_ENTITY	Identifying androsterone -LRB- ADT -RRB- as a cognate substrate for human dehydroepiandrosterone_sulfotransferase -LRB- DHEA-ST -RRB- important for steroid homeostasis : structure of the enzyme-ADT complex .
16675527	0	androsterone	72,84	farnesoid_X_receptor	29,49	androsterone	farnesoid X receptor	MESH:D000738	20186(Tax:10090)	Chemical	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	The nuclear hormone receptor farnesoid_X_receptor -LRB- FXR -RRB- is activated by androsterone .
24525130	0	anethole	65,73	CXCR4	0,5	anethole	CXCR4	MESH:C006578	7852	Chemical	Gene	regulation|nmod|START_ENTITY involved|nmod|regulation involved|nsubjpass|END_ENTITY	CXCR4 and PTEN are involved in the anti-metastatic regulation of anethole in DU145_prostate_cancer cells .
16252076	0	anethole_dithiolethione	16,39	monoamine_oxidase-B	49,68	anethole dithiolethione	monoamine oxidase-B	null	4129	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	The antioxidant anethole_dithiolethione inhibits monoamine_oxidase-B but not monoamine_oxidase_A activity in extracts of cultured astrocytes .
7679494	0	angiogenin	31,41	Actin	0,5	angiogenin	Actin	null	528168(Tax:9913)	Chemical	Gene	protein|nmod|START_ENTITY protein|nsubj|END_ENTITY	Actin is a binding protein for angiogenin .
2742853	0	angiogenin	66,76	placental_ribonuclease_inhibitor	11,43	angiogenin	placental ribonuclease inhibitor	null	6050	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of placental_ribonuclease_inhibitor to the active site of angiogenin .
23389031	0	angiomotin	123,133	cell_adhesion_molecule	17,39	angiomotin	cell adhesion molecule	null	4162	Chemical	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Soluble melanoma cell_adhesion_molecule -LRB- sMCAM/sCD146 -RRB- promotes angiogenic effects on endothelial progenitor cells through angiomotin .
15370298	0	angiopoietin	33,45	tie2	14,18	angiopoietin	tie2	null	7010	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of tie2 expression by angiopoietin -- potential feedback system .
9657920	0	angiostatin	107,118	bFGF	84,88	angiostatin	bFGF	MESH:D043168	2247	Chemical	Gene	stimulation|nmod|START_ENTITY stimulation|nmod|END_ENTITY	A novel assay of angiogenesis in the quail chorioallantoic membrane : stimulation by bFGF and inhibition by angiostatin according to fractal dimension and grid intersection .
9252380	0	angiostatin	14,25	plasmin	58,65	angiostatin	plasmin	MESH:D043168	5340	Chemical	Gene	Generation|nmod|START_ENTITY Generation|nmod|END_ENTITY	Generation of angiostatin by reduction and proteolysis of plasmin .
16689764	0	angiostatin	23,34	urokinase_plasminogen_activator	47,78	angiostatin	urokinase plasminogen activator	MESH:D043168	5328	Chemical	Gene	START_ENTITY|acl|mediated mediated|nmod|END_ENTITY	Generation of platelet angiostatin mediated by urokinase_plasminogen_activator : effects on angiogenesis .
26548625	0	angiotensin	146,157	AT1	158,161	angiotensin	AT1	MESH:D000809	185	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|compound|END_ENTITY	Pharmacological significance of the interplay between angiotensin receptors : MAS receptors as putative final mediators of the effects elicited by angiotensin AT1 receptors antagonists .
26548625	0	angiotensin	54,65	AT1	158,161	angiotensin	AT1	MESH:D000809	185	Chemical	Gene	receptors|compound|START_ENTITY interplay|nmod|receptors significance|nmod|interplay significance|dep|receptors receptors|nmod|mediators mediators|nmod|effects effects|acl|elicited elicited|nmod|antagonists antagonists|compound|END_ENTITY	Pharmacological significance of the interplay between angiotensin receptors : MAS receptors as putative final mediators of the effects elicited by angiotensin AT1 receptors antagonists .
9570482	0	angiotensin	68,79	AT2	80,83	angiotensin	AT2	MESH:D000809	186	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	N - and C-terminal structure-activity study of angiotensin_II on the angiotensin AT2 receptor .
25225202	0	angiotensin	24,35	Angiotensin_II	0,14	angiotensin	Angiotensin II	MESH:D000809	11606(Tax:10090)	Chemical	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	Angiotensin_II mediates angiotensin converting enzyme type 2 internalization and degradation through an angiotensin_II type I receptor-dependent mechanism .
20722844	0	angiotensin	6,17	Renin	0,5	angiotensin	Renin	MESH:D000809	5972	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Renin angiotensin system gene polymorphisms modify angiotensin-converting enzyme inhibitors ' effect on cognitive function : the health , aging and body composition study .
195820	0	angiotensin	96,107	angiotensin_II	36,50	angiotensin	angiotensin II	MESH:D000809	24179(Tax:10116)	Chemical	Gene	influence|nmod|START_ENTITY changes|dep|influence changes|nmod|receptors receptors|compound|END_ENTITY	Post-nephrectomy changes in adrenal angiotensin_II receptors in the rat ; influence of exogenous angiotensin and a competitive inhibitor .
25225202	0	angiotensin	24,35	angiotensin_II	104,118	angiotensin	angiotensin II	MESH:D000809	11606(Tax:10090)	Chemical	Gene	START_ENTITY|acl|converting converting|dobj|internalization internalization|advmod|degradation degradation|nmod|type type|amod|END_ENTITY	Angiotensin_II mediates angiotensin converting enzyme type 2 internalization and degradation through an angiotensin_II type I receptor-dependent mechanism .
8959747	0	angiotensin	10,21	angiotensin_II	53,67	angiotensin	angiotensin II	MESH:D000809	183	Chemical	Gene	component|nsubj|START_ENTITY component|nmod|immunoreactivity immunoreactivity|amod|END_ENTITY	Bioactive angiotensin -LRB- 1-8 -RRB- is the main component of angiotensin_II immunoreactivity in human follicular fluid .
9570482	0	angiotensin	68,79	angiotensin_II	46,60	angiotensin	angiotensin II	MESH:D000809	183	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	N - and C-terminal structure-activity study of angiotensin_II on the angiotensin AT2 receptor .
10415540	0	angiotensin	31,42	bradykinin	15,25	angiotensin	bradykinin	MESH:D000809	3827	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of bradykinin with angiotensin , prostacyclin , and nitric_oxide in myocardial preservation .
4362948	0	angiotensin	47,58	renin	62,67	angiotensin	renin	MESH:D000809	24715(Tax:10116)	Chemical	Gene	dependence|nmod|START_ENTITY dependence|nmod|secretion secretion|compound|END_ENTITY	Calcium dependence of the inhibitory effect of angiotensin on renin secretion in the isolated perfused kidney of the rat .
10771296	0	angiotensin_I	69,82	Angiotensin_I-converting_enzyme	0,31	angiotensin I	Angiotensin I-converting enzyme	MESH:D000803	24310(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Angiotensin_I-converting_enzyme activity and vascular sensitivity to angiotensin_I in rat injured carotid artery .
119623	0	angiotensin_I	37,50	Renin	0,5	angiotensin I	Renin	MESH:D000803	5972	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Renin activity and concentrations of angiotensin_I and II in amniotic fluid of normal and Rh-sensitized pregnancies .
1130560	0	angiotensin_II	10,24	renin	60,65	angiotensin II	renin	MESH:D000804	403838(Tax:9615)	Chemical	Gene	Effect|nmod|START_ENTITY inhibitor|nsubj|Effect inhibitor|nmod|secretion secretion|compound|END_ENTITY	Effect of angiotensin_II and an angiotensin_II inhibitor on renin secretion in the dog .
2988837	0	angiotensin_II	22,36	renin	62,67	angiotensin II	renin	MESH:D000804	403838(Tax:9615)	Chemical	Gene	START_ENTITY|dobj|activity activity|compound|END_ENTITY	Correlation of plasma angiotensin_II concentration and plasma renin activity during acute hypoxia in dogs .
11207430	0	angiotensin_IV	16,30	AT4_receptor	46,58	angiotensin IV	AT4 receptor	MESH:C012877	4012	Chemical	Gene	sites|amod|START_ENTITY sites|appos|END_ENTITY	Distribution of angiotensin_IV binding sites -LRB- AT4_receptor -RRB- in the human forebrain , midbrain and pons as visualised by in vitro receptor autoradiography .
19207373	0	angiotensin_IV	44,58	IRAP	0,4	angiotensin IV	IRAP	MESH:C012877	4012	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|dep|effects	IRAP and AT -LRB- 1 -RRB- receptor mediated effects of angiotensin_IV .
21047126	0	angiotensin_IV	43,57	IRAP	130,134	angiotensin IV	IRAP	MESH:C012877	4012	Chemical	Gene	analogues|nmod|START_ENTITY cyclized|dobj|analogues cyclized|nmod|inhibitors inhibitors|nmod|insulin-regulated_aminopeptidase insulin-regulated_aminopeptidase|appos|END_ENTITY	Disulfide cyclized tripeptide analogues of angiotensin_IV as potent and selective inhibitors of insulin-regulated_aminopeptidase -LRB- IRAP -RRB- .
17447782	0	anibamine	19,28	CCR5	78,82	anibamine	CCR5	MESH:C488244	1234	Chemical	Gene	synthesis|nmod|START_ENTITY synthesis|appos|product product|nmod|antagonist antagonist|compound|END_ENTITY	Total synthesis of anibamine , a novel natural product as a chemokine receptor CCR5 antagonist .
19166361	0	anibamine	29,38	CCR5	87,91	anibamine	CCR5	MESH:C488244	1234	Chemical	Gene	study|nmod|START_ENTITY antagonist|nsubj|study antagonist|nmod|models models|nummod|END_ENTITY	Comparative docking study of anibamine as the first natural product CCR5 antagonist in CCR5 homology models .
21820898	0	anibamine	36,45	CCR5	20,24	anibamine	CCR5	MESH:C488244	1234	Chemical	Gene	antagonist|dobj|START_ENTITY antagonist|nsubj|END_ENTITY	The natural product CCR5 antagonist anibamine and its analogs as anti-prostate_cancer agents .
26096680	0	anibamine	31,40	CCR5	93,97	anibamine	CCR5	MESH:C488244	1234	Chemical	Gene	START_ENTITY|dobj|modification modification|nmod|development development|nmod|antagonists antagonists|compound|END_ENTITY	Exploration on natural product anibamine side chain modification toward development of novel CCR5 antagonists and potential anti-prostate_cancer agents .
16455282	0	aniline	33,40	US/O3	0,5	aniline	US/O3	MESH:C023650	28879	Chemical	Gene	degradation|nmod|START_ENTITY degradation|compound|END_ENTITY	US/O3 combination degradation of aniline in aqueous solution .
21189545	0	aniracetam	14,24	BCL-2	87,92	aniracetam	BCL-2	MESH:C036466	24224(Tax:10116)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	-LSB- Influence of aniracetam on the learning ability , memory ability and the expression of BCL-2 of hippocampal in vascular_dementia model rats -RSB- .
24548428	0	anisodamine	105,116	IL-17A	14,20	anisodamine	IL-17A	MESH:C003922	301289(Tax:10116)	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of IL-17A and IL-17F in lipopolysaccharide-induced acute_lung_injury and the counteraction of anisodamine or methylprednisolone .
25757971	0	anisodamine	11,22	connexin_43	37,48	anisodamine	connexin 43	MESH:C003922	100518636	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	-LSB- Effect of anisodamine on myocardial connexin_43 expression in pig after resuscitation from cardiac_arrest -RSB- .
17945081	0	anisodamine	23,34	intercellular_adhesion_molecule-1	103,136	anisodamine	intercellular adhesion molecule-1	MESH:C003922	25464(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|END_ENTITY	-LSB- Inhibitory effects of anisodamine and pentoxifylline on the expression of lipopolysaccharide - induced intercellular_adhesion_molecule-1 in rat cardiac muscle -RSB- .
22340563	0	anisodamine	11,22	vascular_endothelial_growth_factor	45,79	anisodamine	vascular endothelial growth factor	MESH:C003922	100008899(Tax:9986)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expressions expressions|nmod|END_ENTITY	Effects of anisodamine on the expressions of vascular_endothelial_growth_factor and intercellular_adhesion_molecule_1 in experimental infusion phlebitis .
23582782	0	anisomycin	53,63	Bid	113,116	anisomycin	Bid	MESH:D000841	637	Chemical	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	Synergistic induction of TRAIL-mediated apoptosis by anisomycin in human hepatoma cells via the BH3-only_protein Bid and c-Jun/AP -1 signaling pathway .
18674443	0	anisomycin	11,21	CD1	65,68	anisomycin	CD1	MESH:D000841	111334(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|mice mice|compound|END_ENTITY	Effects of anisomycin on inhibitory avoidance in male and female CD1 mice .
23192275	0	anisomycin	9,19	TRAIL	49,54	anisomycin	TRAIL	MESH:D000841	8743	Chemical	Gene	sensitizes|nsubj|START_ENTITY sensitizes|xcomp|END_ENTITY	Low-dose anisomycin sensitizes melanoma cells to TRAIL induced apoptosis .
10666409	13	anisomycin	2184,2194	ischemia	2209,2217	anisomycin	MAPKAPK2	MESH:D000841	100009438(Tax:9986)	Chemical	Gene	treated|nmod|START_ENTITY treated|nmod|END_ENTITY	As a positive control , a third group of hearts was treated with anisomycin before global ischemia , and in these , JNK activity increased by 290 % above baseline .
11701619	0	anisomycin	46,56	p38	0,3	anisomycin	p38	MESH:D000841	26416(Tax:10090)	Chemical	Gene	elicited|nmod|START_ENTITY preconditioning|acl|elicited preconditioning|compound|END_ENTITY	p38 Triggers late preconditioning elicited by anisomycin in heart : involvement of NF-kappaB and iNOS .
10747897	4	anisomycin	788,798	p53	859,862	anisomycin	p38	MESH:D000841	1432	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Furthermore , we demonstrate that anisomycin - and tumor_necrosis_factor-alpha-induced phosphorylation of p53 at Ser-392 , which is important for the transcriptional activity of this growth suppressor protein , requires p38 MAP kinase and CK2 activities .
12093591	0	anpirtoline	121,132	5-HT1B_receptor	136,151	anpirtoline	5-HT1B receptor	MESH:C075631	15551(Tax:10090)	Chemical	Gene	inhibition|nmod|START_ENTITY mice|dep|inhibition mice|dep|agonist agonist|amod|END_ENTITY	Aggression escalated by social instigation or by discontinuation of reinforcement -LRB- `` frustration '' -RRB- in mice : inhibition by anpirtoline : a 5-HT1B_receptor agonist .
7881726	0	anpirtoline	29,40	5-HT3_receptor	0,14	anpirtoline	5-HT3 receptor	MESH:C075631	79246(Tax:10116)	Chemical	Gene	antagonism|nmod|START_ENTITY antagonism|amod|END_ENTITY	5-HT3_receptor antagonism by anpirtoline , a mixed 5-HT1 receptor agonist/5-HT 3_receptor antagonist .
11835313	0	ansamycins	23,33	nitric_oxide_synthase	47,68	ansamycins	nitric oxide synthase	MESH:D047029	24599(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Suppressive effects of ansamycins on inducible nitric_oxide_synthase expression and the development of experimental_autoimmune_encephalomyelitis .
12376179	0	antalarmin	11,21	CRF	25,28	antalarmin	CRF	MESH:C103016	81648(Tax:10116)	Chemical	Gene	START_ENTITY|appos|type type|compound|END_ENTITY	Effects of antalarmin , a CRF type 1 receptor antagonist , on anxiety-like behavior and motor activation in the rat .
23211705	0	antalarmin	37,47	CRH	14,17	antalarmin	CRH	MESH:C103016	12918(Tax:10090)	Chemical	Gene	effect|acl|START_ENTITY effect|nmod|END_ENTITY	The effect of CRH and its inhibitor , antalarmin , on in vitro growth of preantral mouse follicles , early embryo development , and steroidogenesis .
16000149	0	antalarmin	71,81	corticotropin-releasing_factor	8,38	antalarmin	corticotropin-releasing factor	MESH:C103016	81648(Tax:10116)	Chemical	Gene	antagonism|nmod|START_ENTITY antagonism|compound|END_ENTITY	Chronic corticotropin-releasing_factor type 1 receptor antagonism with antalarmin regulates the dopaminergic system of Fawn-Hooded rats .
12097816	0	antalarmin	10,20	corticotropin-releasing_hormone	30,61	antalarmin	corticotropin-releasing hormone	MESH:C103016	1392	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Effect of antalarmin , a novel corticotropin-releasing_hormone antagonist , on the dynamic function of the preterm ovine fetal_hypothalamo-pituitary-adrenal_axis .
9886810	0	antalarmin	72,82	corticotropin-releasing_hormone	29,60	antalarmin	corticotropin-releasing hormone	MESH:C103016	81648(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|impact impact|nmod|antagonist antagonist|amod|END_ENTITY	The impact of the nonpeptide corticotropin-releasing_hormone antagonist antalarmin on behavioral and endocrine responses to stress .
15792247	0	antalarmin	30,40	corticotropin-releasing_hormone_receptor-1	50,92	antalarmin	corticotropin-releasing hormone receptor-1	MESH:C103016	1394	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Quantitative determination of antalarmin , a novel corticotropin-releasing_hormone_receptor-1 antagonist , in canine plasma by HPLC-MS .
23320385	0	anthocyanidins	21,35	glutathione_S-transferase	47,72	anthocyanidins	glutathione S-transferase	MESH:D000872	58962(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activities activities|amod|END_ENTITY	Inhibitory effect of anthocyanidins on hepatic glutathione_S-transferase , UDP-glucuronosyltransferase and carbonyl_reductase activities in rat and human .
24467527	0	anthocyanin	92,103	COI1	121,125	anthocyanin	COI1	MESH:D000872	818581(Tax:3702)	Chemical	Gene	biosynthesis|compound|START_ENTITY biosynthesis|nmod|END_ENTITY	THF1 mutations lead to increased basal and wound-induced levels of oxylipins that stimulate anthocyanin biosynthesis via COI1 signaling in Arabidopsis .
24190183	0	anthocyanin	57,68	bean	82,86	anthocyanin	bean	MESH:D000872	146227	Chemical	Gene	phenotype|compound|START_ENTITY phenotype|nmod|END_ENTITY	Light and developmental regulation of the Anp-controlled anthocyanin phenotype of bean pods .
19808084	0	anthocyanins	65,77	ACE	44,47	anthocyanins	ACE	MESH:D000872	1636	Chemical	Gene	activity|nmod|START_ENTITY activity|appos|END_ENTITY	Inhibition of angiotensin convertin enzyme -LRB- ACE -RRB- activity by the anthocyanins delphinidin - and cyanidin-3-O-sambubiosides from Hibiscus sabdariffa .
24177565	0	anthocyanins	49,61	Gadd45	20,26	anthocyanins	Gadd45	MESH:D000872	1647	Chemical	Gene	roles|nmod|START_ENTITY roles|nmod|END_ENTITY	Protective roles of Gadd45 and MDM2 in blueberry anthocyanins mediated DNA repair of fragmented and non-fragmented DNA damage in UV-irradiated HepG2 cells .
15631504	0	anthocyanins	31,43	Insulin	0,7	anthocyanins	Insulin	MESH:D000872	3630	Chemical	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Insulin secretion by bioactive anthocyanins and anthocyanidins present in fruits .
23925404	0	anthocyanins	74,86	SOS3	48,52	anthocyanins	SOS3	MESH:D000872	832494(Tax:3702)	Chemical	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	The Arabidopsis_thaliana mutant air1 implicates SOS3 in the regulation of anthocyanins under salt stress .
24374256	0	anthocyanins	26,38	acetylcholinesterase	42,62	anthocyanins	acetylcholinesterase	MESH:D000872	83817(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Neuroprotective effect of anthocyanins on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia in rats .
21761876	0	anthocyanins	24,36	eNOS	93,97	anthocyanins	eNOS	MESH:D000872	4846	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Effect of black currant anthocyanins on the activation of endothelial_nitric_oxide_synthase -LRB- eNOS -RRB- in vitro in human endothelial cells .
19921836	0	anthocyanins	86,98	ferritin	66,74	anthocyanins	ferritin	MESH:D000872	547824(Tax:3847)	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Comparative study on iron release from soybean -LRB- Glycine_max -RRB- seed ferritin induced by anthocyanins and ascorbate .
7480181	0	anthracenones	37,50	catalase	54,62	anthracenones	catalase	null	531682(Tax:9913)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	Effect of peroxisomicine and related anthracenones on catalase activity .
15809684	0	anthracnose	74,85	lupin	108,113	anthracnose	lupin	null	51251	Chemical	Gene	resistance|amod|START_ENTITY resistance|nmod|END_ENTITY	A PCR-based molecular marker applicable for marker-assisted selection for anthracnose disease resistance in lupin breeding .
26752929	0	anthracycline	60,73	HER2	20,24	anthracycline	HER2	D018943	2064	Chemical	Gene	status|nmod|START_ENTITY status|compound|END_ENTITY	Association between HER2 status and response to neoadjuvant anthracycline followed by paclitaxel plus carboplatin chemotherapy without trastuzumab in breast_cancer .
10070877	0	anthracycline	37,50	MDR1	13,17	anthracycline	MDR1	CHEBI:48120	5243	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Induction of MDR1 gene expression by anthracycline analogues in a human drug_resistant_leukaemia cell line .
9029024	0	anthracycline	105,118	MDR1	35,39	anthracycline	MDR1	CHEBI:48120	5243	Chemical	Gene	toxicity|amod|START_ENTITY protects|nmod|toxicity protects|nsubj|expression expression|compound|END_ENTITY	A low but functionally significant MDR1 expression protects primitive haemopoietic progenitor cells from anthracycline toxicity .
10421076	0	anthracycline	53,66	MX2	28,31	anthracycline	MX2	CHEBI:48120	4600	Chemical	Gene	derivative|compound|START_ENTITY study|appos|derivative study|appos|END_ENTITY	A phase II study of KRN8602 -LRB- MX2 -RRB- , a novel morpholino anthracycline derivative , in patients with recurrent malignant_glioma .
1988080	0	anthracycline	47,60	MX2	25,28	anthracycline	MX2	CHEBI:48120	4600	Chemical	Gene	pharmacology|appos|START_ENTITY pharmacology|nmod|END_ENTITY	Cellular pharmacology of MX2 , a new morpholino anthracycline , in human pleiotropic drug-resistant cells .
2369088	0	anthracycline	32,45	MX2	10,13	anthracycline	MX2	CHEBI:48120	286918(Tax:10116)	Chemical	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of MX2 , a new morpholino anthracycline , against experimental brain_tumors .
7501112	0	anthracycline	46,59	MX2	24,27	anthracycline	MX2	CHEBI:48120	4600	Chemical	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The antitumor effect of MX2 , a new morpholino anthracycline , against malignant_glioma cell lines and its subcellular distribution .
7577142	0	anthracycline	43,56	MX2	21,24	anthracycline	MX2	CHEBI:48120	4600	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|END_ENTITY	-LSB- Antitumor effect of MX2 , a new morpholino anthracycline against C6_glioma cells and its combination effect with photodynamic therapy in vitro -RSB- .
7984256	0	anthracycline	80,93	MX2	58,61	anthracycline	MX2	CHEBI:48120	286918(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|localization localization|nmod|END_ENTITY	Subcellular localization and cellular pharmacokinetics of MX2 , a new morpholino anthracycline in glioma cells using confocal laser scanning microscopy .
8333749	0	anthracycline	43,56	MX2	21,24	anthracycline	MX2	CHEBI:48120	100009451(Tax:9986)	Chemical	Gene	Pharmacokinetics|appos|START_ENTITY Pharmacokinetics|nmod|END_ENTITY	-LSB- Pharmacokinetics of MX2 , a new morpholino anthracycline , in CSF following intravenous injection -RSB- .
9293905	0	anthracycline	82,95	MX2	64,67	anthracycline	MX2	CHEBI:48120	4600	Chemical	Gene	START_ENTITY|advcl|Induction Induction|nmod|END_ENTITY	Induction of apoptosis in megakaryocytic_leukemia cell lines by MX2 , a morpholino anthracycline .
9881081	0	anthracycline	48,61	MX2	34,37	anthracycline	MX2	CHEBI:48120	4600	Chemical	Gene	START_ENTITY|advcl|-LSB- -LSB-|dobj|study study|nmod|KRN8602 KRN8602|appos|END_ENTITY	-LSB- Early phase II study of KRN8602 -LRB- MX2 -RRB- , a novel anthracycline derivative for acute_leukemia -RSB- .
9987504	0	anthracycline	53,66	MX2	39,42	anthracycline	MX2	CHEBI:48120	4600	Chemical	Gene	derivative|compound|START_ENTITY study|appos|derivative study|appos|END_ENTITY	-LSB- Pilot late phase II study of KRN8602 -LRB- MX2 -RRB- , a novel anthracycline derivative , for acute_leukemia -- a dose finding study in combination -RSB- .
20010949	0	anthracycline	25,38	PSMB7	0,5	anthracycline	PSMB7	CHEBI:48120	64278(Tax:7955)	Chemical	Gene	resistance|amod|START_ENTITY associated|nmod|resistance associated|nsubjpass|END_ENTITY	PSMB7 is associated with anthracycline resistance and is a prognostic biomarker in breast_cancer .
3856679	0	anthracycline	39,52	low-density_lipoprotein_receptor	71,103	anthracycline	low-density lipoprotein receptor	CHEBI:48120	3949	Chemical	Gene	START_ENTITY|nmod|pathway pathway|amod|END_ENTITY	Selective uptake of a toxic lipophilic anthracycline derivative by the low-density_lipoprotein_receptor pathway in cultured fibroblasts .
1968051	0	anthracycline	121,134	mdr1	22,26	anthracycline	mdr1	CHEBI:48120	5243	Chemical	Gene	accumulation|amod|START_ENTITY associated|nmod|accumulation associated|nsubjpass|Overexpression Overexpression|nmod|gene gene|amod|END_ENTITY	Overexpression of the mdr1 gene in blast cells from patients with acute_myelocytic_leukemia is associated with decreased anthracycline accumulation that can be restored by cyclosporin-A .
22465428	0	anthracyclines	82,96	CITED2	114,120	anthracyclines	CITED2	MESH:D018943	10370	Chemical	Gene	START_ENTITY|nmod|induction induction|nmod|END_ENTITY	Pan-histone_deacetylase inhibitor panobinostat sensitizes gastric_cancer cells to anthracyclines via induction of CITED2 .
18159072	0	anthracyclines	37,51	HER2	0,4	anthracyclines	HER2	MESH:D018943	2064	Chemical	Gene	status|nmod|START_ENTITY status|compound|END_ENTITY	HER2 status and efficacy of adjuvant anthracyclines in early breast_cancer : a pooled analysis of randomized trials .
18445822	0	anthracyclines	41,55	HER2	4,8	anthracyclines	HER2	MESH:D018943	2064	Chemical	Gene	status|nmod|START_ENTITY status|compound|END_ENTITY	Re : HER2 status and efficacy of adjuvant anthracyclines in early breast_cancer : a pooled analysis of randomized trials .
21229877	0	anthracyclines	48,62	HSP60	17,22	anthracyclines	HSP60	MESH:D018943	3329	Chemical	Gene	action|nmod|START_ENTITY role|nmod|action role|nmod|END_ENTITY	Possible role of HSP60 in synergistic action of anthracyclines and sulindac in HeLa cells .
10500807	0	anthracyclines	13,27	MDR1	61,65	anthracyclines	MDR1	MESH:D018943	5243	Chemical	Gene	START_ENTITY|nmod|concentrations concentrations|nmod|END_ENTITY	Apoptosis by anthracyclines at therapeutic concentrations in MDR1 + human leukemic cells .
9816222	0	anthracyclines	70,84	MDR1	51,55	anthracyclines	MDR1	MESH:D018943	5243	Chemical	Gene	prevent|nmod|START_ENTITY prevent|dobj|up-regulation up-regulation|nmod|expression expression|compound|END_ENTITY	Cyclosporin_A and PSC_833 prevent up-regulation of MDR1 expression by anthracyclines in a human multidrug-resistant cell line .
25068025	0	anthracyclines	78,92	erbB	13,17	anthracyclines	erbB	MESH:D018943	1956	Chemical	Gene	activities|nmod|START_ENTITY activities|amod|END_ENTITY	Neuregulin-1 / erbB activities with focus on the susceptibility of the heart to anthracyclines .
7734315	0	anthracyclines	42,56	mdr1	23,27	anthracyclines	mdr1	MESH:D018943	5243	Chemical	Gene	up-regulation|nmod|START_ENTITY up-regulation|nmod|expression expression|amod|END_ENTITY	Rapid up-regulation of mdr1 expression by anthracyclines in a classical multidrug-resistant cell line .
16503553	0	anthracyline	51,63	CHOP	43,47	anthracyline	CHOP	null	1649	Chemical	Gene	resistance|amod|START_ENTITY END_ENTITY|nmod|resistance	The effect of pre-irradiation dose intense CHOP on anthracyline resistance in localized nasal NK/T-cell _ lymphoma .
2529149	0	anthralin	25,34	Calmodulin	0,10	anthralin	Calmodulin	MESH:D000875	808	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|END_ENTITY	Calmodulin inhibition by anthralin ?
10733674	0	anthralin	20,29	JNK	40,43	anthralin	JNK	MESH:D000875	5599	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Anti-psoriatic drug anthralin activates JNK via lipid peroxidation : mononuclear cells are more sensitive than keratinocytes .
8666828	0	anthralin	20,29	NF-kappa_B	61,71	anthralin	NF-kappa B	MESH:D000875	18033(Tax:10090)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Anti-psoriatic drug anthralin activates transcription factor NF-kappa_B in murine keratinocytes .
6744241	0	anthralin	36,45	ornithine_decarboxylase	62,85	anthralin	ornithine decarboxylase	MESH:D000875	24609(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of 1,8-dihydroxy-9-anthrone -LRB- anthralin -RRB- on rat hepatic ornithine_decarboxylase activity in vivo .
2720404	0	anthramycin	30,41	Cholecystokinin	0,15	anthramycin	Cholecystokinin	MESH:D000876	12424(Tax:10090)	Chemical	Gene	antagonism|nmod|START_ENTITY antagonism|nsubj|END_ENTITY	Cholecystokinin antagonism by anthramycin , a benzodiazepine antibiotic , in the central nervous system in mice .
25839438	0	anthranilamide	18,32	factor_Xa	58,67	anthranilamide	factor Xa	MESH:C000219	2159	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|inhibitors inhibitors|compound|END_ENTITY	Identification of anthranilamide derivatives as potential factor_Xa inhibitors : Drug design , synthesis and biological evaluation .
16335920	0	anthranilic_acid	62,78	acyl_carrier_protein_synthase	79,108	anthranilic acid	acyl carrier protein synthase	MESH:C031385	60496	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Use of structure-based drug design approaches to obtain novel anthranilic_acid acyl_carrier_protein_synthase inhibitors .
16789740	0	anthranilic_acid_sulfonamides	30,59	methionine_aminopeptidase-2	77,104	anthranilic acid sulfonamides	methionine aminopeptidase-2	null	10988	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Discovery and optimization of anthranilic_acid_sulfonamides as inhibitors of methionine_aminopeptidase-2 : a structural basis for the reduction of albumin binding .
25737085	0	anthranilic_acids	31,48	HCA2	52,56	anthranilic acids	HCA2	MESH:D062367	139081	Chemical	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	Affinity and kinetics study of anthranilic_acids as HCA2 receptor agonists .
10966161	0	anthranoyl-anthranilic_acid	11,38	CCK	75,78	anthranoyl-anthranilic acid	CCK	null	885	Chemical	Gene	START_ENTITY|nmod|receptors receptors|compound|END_ENTITY	C-terminal anthranoyl-anthranilic_acid derivatives and their evaluation on CCK receptors .
18841780	0	anthraquinone	17,30	aquaporin_2	43,54	anthraquinone	aquaporin 2	CHEBI:40448	25386(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effect of total anthraquinone in rheum on aquaporin_2 expression in rat distal colon -RSB- .
1578486	0	anthraquinone	6,19	human_leukocyte_elastase	34,58	anthraquinone	human leukocyte elastase	CHEBI:40448	1991	Chemical	Gene	START_ENTITY|dobj|inhibitors inhibitors|nmod|END_ENTITY	Novel anthraquinone inhibitors of human_leukocyte_elastase and cathepsin_G .
22951468	0	antiandrogen_flutamide	17,39	androgen_receptor	47,64	antiandrogen flutamide	androgen receptor	null	397582(Tax:9823)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Influence of the antiandrogen_flutamide on the androgen_receptor gene expression in the placenta and umbilical cord during pregnancy in the pig .
15952300	0	anticholesterol	10,25	ICAM-1	45,51	anticholesterol	ICAM-1	null	3383	Chemical	Gene	therapy|amod|START_ENTITY Effect|nmod|therapy Effect|nmod|END_ENTITY	Effect of anticholesterol therapy on soluble ICAM-1 in chronic_stroke patients with hyperlipidemia .
26849233	0	antiestrogen	21,33	HIF2a	0,5	antiestrogen	HIF2a	MESH:D020847	2034	Chemical	Gene	contributes|xcomp|START_ENTITY contributes|nsubj|END_ENTITY	HIF2a contributes to antiestrogen resistance via positive bilateral crosstalk with EGFR in breast_cancer cells .
26849233	7	antiestrogen	1133,1145	HIF2a	1124,1129	antiestrogen	HIF2a	MESH:D020847	2034	Chemical	Gene	resistance|compound|START_ENTITY END_ENTITY|nmod|resistance	Ectopic expression of HIF2a in MCF-7 cells significantly decreased sensitivity to antiestrogens , further implicating HIF2a in antiestrogen resistance .
8772706	0	antihistamine_terfenadine	60,85	HERG	0,4	antihistamine terfenadine	HERG	null	3757	Chemical	Gene	target|nmod|START_ENTITY END_ENTITY|appos|target	HERG , a primary human ventricular target of the nonsedating antihistamine_terfenadine .
1168499	1	antimycin	67,76	Cytochrome_b	80,92	antimycin	Cytochrome b	MESH:C032456	4519	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of antimycin on Cytochrome_b .
3028506	0	antimycin	156,165	cytochrome_b	41,53	antimycin	cytochrome b	MESH:C032456	854583(Tax:4932)	Chemical	Gene	site|compound|START_ENTITY consequence|nmod|site III|dep|consequence observed|dobj|III observed|nsubj|Effects Effects|nmod|mutation mutation|nmod|gene gene|amod|END_ENTITY	Effects of a missense exonic mutation in cytochrome_b gene , observed on isolated mitochondrial complex III of Saccharomyces_cerevisiae : consequence for the antimycin binding site .
8394993	0	antimycin_A	24,35	transferrin	69,80	antimycin A	transferrin	MESH:D000968	7018	Chemical	Gene	START_ENTITY|nmod|endocytosis endocytosis|nmod|END_ENTITY	Differential effects of antimycin_A on endocytosis and exocytosis of transferrin also are observed for internalization and externalization of beta-adrenergic receptors .
7694235	0	antiphosphotyrosine	10,29	TIK	53,56	antiphosphotyrosine	TIK	null	19106(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	The mouse antiphosphotyrosine immunoreactive kinase , TIK , is indistinguishable from the double-stranded RNA-dependent , interferon-induced protein kinase , PKR .
1954877	0	antiprogesterone	21,37	relaxin	64,71	antiprogesterone	relaxin	null	396891(Tax:9823)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Divergent effects of antiprogesterone , RU_486 , on progesterone , relaxin , and prolactin secretion in pregnant and hysterectomized pigs with aging corpora lutea .
24756033	0	antiprogesterone_RU486	10,32	VEGF	36,40	antiprogesterone RU486	VEGF	null	7422	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effect of antiprogesterone_RU486 on VEGF expression and blood vessel remodeling on ovarian follicles before ovulation .
7854344	0	antiprogesterone_ZK98299	33,57	progesterone_receptor	63,84	antiprogesterone ZK98299	progesterone receptor	null	5241	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of newly synthesized antiprogesterone_ZK98299 with progesterone_receptor from human myometrium .
2343186	0	antipyrine	54,64	cytochrome_P-450	14,30	antipyrine	cytochrome P-450	MESH:D000983	25251(Tax:10116)	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|amod|END_ENTITY	Evaluation of cytochrome_P-450 mediated metabolism of antipyrine in the rat at different extents of fluosol-DA hemodilution .
11847531	0	antipyrine	60,70	cytochrome_P450	107,122	antipyrine	cytochrome P450	MESH:D000983	4051	Chemical	Gene	START_ENTITY|nmod|drug drug|nmod|END_ENTITY	Albendazole metabolism in patients with neurocysticercosis : antipyrine as a multifunctional marker drug of cytochrome_P450 .
11350681	0	antisterone	53,64	CYP11B2	1,8	antisterone	CYP11B2	null	24294(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	-LSB- CYP11B2 expression in rat liver and the efficacy of antisterone on liver fibrosis -RSB- .
19350452	0	antofloxacin	40,52	CYP1A2	30,36	antofloxacin	CYP1A2	MESH:C522674	24297(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Mechanism-based inhibition of CYP1A2 by antofloxacin , an 8-NH2 derivative of levofloxacin in rats .
24604288	0	apatinib	30,38	VEGFR	48,53	apatinib	VEGFR	MESH:C553458	3791	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Multicenter phase II study of apatinib , a novel VEGFR inhibitor in heavily pretreated patients with metastatic triple-negative breast_cancer .
12688717	0	aphidicolin	81,92	DNA_polymerase_alpha	49,69	aphidicolin	DNA polymerase alpha	MESH:D016590	5422	Chemical	Gene	synthesis|appos|START_ENTITY synthesis|nmod|inhibitor inhibitor|compound|END_ENTITY	Diastereoselective formal total synthesis of the DNA_polymerase_alpha inhibitor , aphidicolin , using palladium-catalyzed cycloalkenylation and intramolecular Diels-Alder reactions .
2505232	0	aphidicolin	79,90	DNA_polymerase_alpha	55,75	aphidicolin	DNA polymerase alpha	MESH:D016590	5422	Chemical	Gene	derivatives|compound|START_ENTITY relationships|nmod|derivatives relationships|nmod|inhibition inhibition|nmod|END_ENTITY	Structure-activity relationships for the inhibition of DNA_polymerase_alpha by aphidicolin derivatives .
3115608	0	aphidicolin	25,36	DNA_polymerase_alpha	86,106	aphidicolin	DNA polymerase alpha	MESH:D016590	5422	Chemical	Gene	modification|nmod|START_ENTITY modification|nmod|END_ENTITY	Chemical modification of aphidicolin and the inhibitory effects of its derivatives on DNA_polymerase_alpha in vitro .
3133639	0	aphidicolin	38,49	DNA_polymerase_alpha	14,34	aphidicolin	DNA polymerase alpha	MESH:D016590	5422	Chemical	Gene	derivatives|compound|START_ENTITY Inhibition|nmod|derivatives Inhibition|nmod|END_ENTITY	Inhibition of DNA_polymerase_alpha by aphidicolin derivatives .
6430783	0	aphidicolin	35,46	DNA_polymerase_alpha	0,20	aphidicolin	DNA polymerase alpha	MESH:D016590	5422	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	DNA_polymerase_alpha inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes .
6784928	0	aphidicolin	72,83	DNA_polymerase_alpha	109,129	aphidicolin	DNA polymerase alpha	MESH:D016590	5422	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	New views of the biochemistry of eucaryotic DNA replication revealed by aphidicolin , an unusual inhibitor of DNA_polymerase_alpha .
6799808	0	aphidicolin	30,41	DNA_polymerase_alpha	68,88	aphidicolin	DNA polymerase alpha	MESH:D016590	5422	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	Effect of post-treatment with aphidicolin - a specific inhibitor of DNA_polymerase_alpha - on sister-chromatid exchanges induced by ethyl_methanesulfonate .
12955081	4	apicidin	1276,1284	PKC_epsilon	1249,1260	apicidin	PKC epsilon	MESH:C102351	5581	Chemical	Gene	response|nmod|START_ENTITY END_ENTITY|nmod|response	Furthermore , membrane translocation of PKC_epsilon in response to apicidin was blocked by the PI 3-kinase inhibitor , indicating the role of PI 3-kinase as an upstream molecule of PKC_epsilon in the p21 -LRB- WAF1/Cip1 -RRB- promoter activation by apicidin .
11237739	0	apicidin	48,56	p21	30,33	apicidin	p21	MESH:C102351	1026	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Transcriptional activation of p21 -LRB- WAF1/CIP1 -RRB- by apicidin , a novel histone deacetylase inhibitor .
11551946	0	apicidin	94,102	p21	14,17	apicidin	p21	MESH:C102351	1026	Chemical	Gene	transcription|nmod|START_ENTITY WAF1/Cip1|acl|transcription WAF1/Cip1|amod|END_ENTITY	Activation of p21 -LRB- WAF1/Cip1 -RRB- transcription through Sp1 sites by histone deacetylase inhibitor apicidin : involvement of protein_kinase_C .
12955081	0	apicidin	80,88	p21	14,17	apicidin	p21	MESH:C102351	1026	Chemical	Gene	sites|nmod|START_ENTITY WAF1/Cip1|nmod|sites WAF1/Cip1|amod|END_ENTITY	Expression of p21 -LRB- WAF1/Cip1 -RRB- through Sp1 sites by histone deacetylase inhibitor apicidin requires PI 3-kinase-PKC_epsilon signaling pathway .
19376607	0	apicidin	19,27	sulfatase_1	47,58	apicidin	sulfatase 1	MESH:C102351	23213	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Additive effect of apicidin and doxorubicin in sulfatase_1 expressing hepatocellular_carcinoma in vitro and in vivo .
23172919	0	apigenin	10,18	CD38	51,55	apigenin	CD38	MESH:D047310	12494(Tax:10090)	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Flavonoid apigenin is an inhibitor of the NAD + ase CD38 : implications for cellular NAD + metabolism , protein acetylation , and treatment of metabolic_syndrome .
24009741	0	apigenin	14,22	CDK1	37,41	apigenin	CDK1	MESH:D047310	983	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	The flavonoid apigenin downregulates CDK1 by directly targeting ribosomal_protein_S9 .
16044407	0	apigenin	65,73	COX-2	44,49	apigenin	COX-2	MESH:D047310	5743	Chemical	Gene	expression|nmod|START_ENTITY expression|nsubj|Inhibition Inhibition|appos|END_ENTITY	Inhibition of TPA-induced cyclooxygenase-2 -LRB- COX-2 -RRB- expression by apigenin through downregulation of Akt signal transduction in human keratinocytes .
17186551	0	apigenin	75,83	COX-2	54,59	apigenin	COX-2	MESH:D047310	19225(Tax:10090)	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|expression expression|appos|END_ENTITY	Modulation of UVB-induced and basal cyclooxygenase-2 -LRB- COX-2 -RRB- expression by apigenin in mouse keratinocytes : role of USF transcription factors .
23266501	3	apigenin	518,526	COX-2	596,601	apigenin	IL-1b	MESH:D047310	3553	Chemical	Gene	effects|nmod|START_ENTITY investigated|dobj|effects investigated|dobj|cells cells|acl:relcl|examined examined|nsubjpass|IkBa IkBa|appos|cyclooxygenase-2 cyclooxygenase-2|appos|END_ENTITY	In this study , we investigated the anti-inflammatory effects of apigenin in H. _ pylori-infected MKN45 cells , for which IkBa , cyclooxygenase-2 -LRB- COX-2 -RRB- , intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- , reactive oxygen species -LRB- ROS -RRB- , interleukin-8 -LRB- IL-8 -RRB- , IL-6 , IL-1b , and mucin-2 -LRB- MUC-2 -RRB- expressions were examined .
20669675	0	apigenin	23,31	GATA-3	53,59	apigenin	GATA-3	MESH:D047310	14462(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Inhibitory effects of apigenin on the expression of GATA-3 and Th2 cytokines in asthmatic mice -RSB- .
23980682	0	apigenin	24,32	GLUT-1	57,63	apigenin	GLUT-1	MESH:D047310	6513	Chemical	Gene	mechanism|nmod|START_ENTITY mechanism|nmod|expression expression|compound|END_ENTITY	Anticancer mechanism of apigenin and the implications of GLUT-1 expression in head_and_neck_cancers .
26238658	0	apigenin	58,66	GLUT-1	11,17	apigenin	GLUT-1	MESH:D047310	6513	Chemical	Gene	using|dobj|START_ENTITY signaling|advcl|using expression|acl|signaling expression|compound|END_ENTITY	Inhibiting GLUT-1 expression and PI3K/Akt signaling using apigenin improves the radiosensitivity of laryngeal_carcinoma in vivo .
22388989	0	apigenin	139,147	MUC5AC	49,55	apigenin	MUC5AC	MESH:D047310	4586	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubj|expression expression|compound|END_ENTITY	Phorbol_ester or epidermal_growth-factor-induced MUC5AC mucin gene expression and production from airway epithelial cells are inhibited by apigenin and wogonin .
18069627	0	apigenin	25,33	VEGF	37,41	apigenin	VEGF	MESH:D047310	7422	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effect and mechanism of apigenin on VEGF expression in human breast_cancer cells -RSB- .
21756884	0	apigenin	62,70	catalase	15,23	apigenin	catalase	MESH:D047310	847	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of catalase in the apoptotic mechanism induced by apigenin in HepG2 human hepatoma cells .
17186551	0	apigenin	75,83	cyclooxygenase-2	36,52	apigenin	cyclooxygenase-2	MESH:D047310	19225(Tax:10090)	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|expression expression|amod|END_ENTITY	Modulation of UVB-induced and basal cyclooxygenase-2 -LRB- COX-2 -RRB- expression by apigenin in mouse keratinocytes : role of USF transcription factors .
19729077	0	apigenin	29,37	heme_oxygenase-1	122,138	apigenin	heme oxygenase-1	MESH:D047310	3162	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Anti-inflammatory effects of apigenin on nicotine - and lipopolysaccharide-stimulated human periodontal ligament cells via heme_oxygenase-1 .
22388989	0	apigenin	139,147	mucin	56,61	apigenin	mucin	MESH:D047310	100508689	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubj|expression expression|compound|END_ENTITY	Phorbol_ester or epidermal_growth-factor-induced MUC5AC mucin gene expression and production from airway epithelial cells are inhibited by apigenin and wogonin .
25489420	1	apigenin	224,232	mucin	336,341	apigenin	mucin	MESH:D047310	100508689	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|tumor_necrosis_factor-a tumor_necrosis_factor-a|dep|production production|nmod|END_ENTITY	In the present study , we investigated whether apigenin significantly affects tumor_necrosis_factor-a -LRB- TNF-a -RRB- - induced production and gene expression of MUC5AC mucin in airway epithelial cells .
16898869	0	apigenin	18,26	ornithine_decarboxylase	38,61	apigenin	ornithine decarboxylase	MESH:D047310	18263(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|compound|END_ENTITY	Effect of dietary apigenin on colonic ornithine_decarboxylase activity , aberrant_crypt_foci formation , and tumorigenesis in different experimental models .
26872304	0	apigenin	78,86	p21	156,159	apigenin	p21	MESH:D047310	1026	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Inhibition of MDA-MB-231_breast_cancer cell proliferation and tumor growth by apigenin through induction of G2/M arrest and histone H3 acetylation-mediated p21 -LRB- WAF1/CIP1 -RRB- expression .
17868430	0	apixaban	27,35	factor_Xa	53,62	apixaban	factor Xa	MESH:C522181	2159	Chemical	Gene	efficacy|nmod|START_ENTITY efficacy|appos|inhibitor inhibitor|compound|END_ENTITY	The efficacy and safety of apixaban , an oral , direct factor_Xa inhibitor , as thromboprophylaxis in patients following total knee replacement .
21318583	0	apixaban	25,33	factor_Xa	68,77	apixaban	factor Xa	MESH:C522181	2159	Chemical	Gene	discovery|nmod|START_ENTITY discovery|appos|inhibitor inhibitor|compound|END_ENTITY	Preclinical discovery of apixaban , a direct and orally bioavailable factor_Xa inhibitor .
21516308	0	apixaban	80,88	factor_Xa	120,129	apixaban	factor Xa	MESH:C522181	2159	Chemical	Gene	properties|nmod|START_ENTITY properties|dep|inhibitor inhibitor|compound|END_ENTITY	Chromogenic laboratory assays to measure the factor_Xa-inhibiting properties of apixaban -- an oral , direct and selective factor_Xa inhibitor .
23451769	0	apixaban	72,80	factor_Xa	84,93	apixaban	factor Xa	MESH:C522181	2159	Chemical	Gene	doses|nmod|START_ENTITY pharmacokinetics|nmod|doses Safety|appos|pharmacokinetics Safety|appos|inhibitor inhibitor|compound|END_ENTITY	Safety , pharmacokinetics and pharmacodynamics of multiple oral doses of apixaban , a factor_Xa inhibitor , in healthy subjects .
23637566	0	apixaban	48,56	factor_Xa	73,82	apixaban	factor Xa	MESH:C522181	2159	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Effect of famotidine on the pharmacokinetics of apixaban , an oral direct factor_Xa inhibitor .
27020211	0	apixaban	46,54	factor_Xa	25,34	apixaban	factor Xa	MESH:C522181	2159	Chemical	Gene	inhibitors|dobj|START_ENTITY inhibitors|nsubj|effect effect|nmod|END_ENTITY	The effect of the direct factor_Xa inhibitors apixaban and rivaroxaban on haemostasis tests : a comprehensive assessment using in vitro and ex vivo samples .
26187443	0	apocarotenoids	21,35	tyrosinase	55,65	apocarotenoids	tyrosinase	CHEBI:53183	22173(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	Inhibitory effect of apocarotenoids on the activity of tyrosinase : Multi-spectroscopic and docking studies .
26187443	0	apocarotenoids	21,35	tyrosinase	55,65	apocarotenoids	tyrosinase	CHEBI:53183	22173(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	Inhibitory effect of apocarotenoids on the activity of tyrosinase : Multi-spectroscopic and docking studies .
16467505	0	apocynin	10,18	COX-2	52,57	apocynin	COX-2	MESH:C056165	26198(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY Effect|nmod|treatment Effect|nmod|END_ENTITY	Effect of apocynin treatment on renal expression of COX-2 , NOS1 , and renin in Wistar-Kyoto and spontaneously hypertensive rats .
23617822	8	apocynin	1300,1308	NADPH	1321,1326	apocynin	MMP-2	MESH:C056165	4313	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Similarly , apocynin , a specific NADPH oxidase inhibitor , also effectively neutralized the effects of HG on barrier integrity , MMP-2 activity , occludin expression and PKC-b activity .
19635468	0	apocynin	21,29	NOX2	0,4	apocynin	NOX2	MESH:C056165	66021(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nummod|END_ENTITY	NOX2 inhibition with apocynin worsens stroke outcome in aged rats .
22240153	0	apocynin	41,49	p47phox	79,86	apocynin	p47phox	MESH:C056165	653361	Chemical	Gene	derived|nmod|START_ENTITY hydroxylated_quinone|acl|derived targets|nsubj|hydroxylated_quinone targets|dobj|residues residues|nmod|END_ENTITY	Trimer hydroxylated_quinone derived from apocynin targets cysteine residues of p47phox preventing the activation of human vascular NADPH oxidase .
23802190	0	apocynin	31,39	p47phox	70,77	apocynin	p47phox	MESH:C056165	653361	Chemical	Gene	derived|nmod|START_ENTITY derived|ccomp|avoid avoid|dobj|interaction interaction|nmod|subunits subunits|amod|END_ENTITY	Ethers and esters derived from apocynin avoid the interaction between p47phox and p22phox subunits of NADPH oxidase : evaluation in vitro and in silico .
22866921	0	apogossypolone	29,43	Bax	0,3	apogossypolone	Bax	MESH:C534401	581	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Bax and Bak are required for apogossypolone , a BH3-mimetic , induced apoptosis in chronic_lymphocytic_leukemia cells .
19823097	0	apogossypolone	23,37	bcl-2	64,69	apogossypolone	bcl-2	MESH:C534401	596	Chemical	Gene	studies|nmod|START_ENTITY studies|appos|inhibitor inhibitor|acl|END_ENTITY	Preclinical studies of apogossypolone , a novel pan inhibitor of bcl-2 and mcl-1 , synergistically potentiates cytotoxic effect of gemcitabine in pancreatic_cancer cells .
22655238	0	apogossypolone	18,32	bcl-2	93,98	apogossypolone	bcl-2	MESH:C534401	12043(Tax:10090)	Chemical	Gene	derivative|compound|START_ENTITY derivative|nmod|proteins proteins|amod|END_ENTITY	An optically pure apogossypolone derivative as potent pan-active inhibitor of anti-apoptotic bcl-2 family proteins .
17187291	0	apomorphine	36,47	Growth_hormone	0,14	apomorphine	Growth hormone	MESH:D001058	2688	Chemical	Gene	test|compound|START_ENTITY response|nmod|test response|amod|END_ENTITY	Growth_hormone response in low-dose apomorphine test correlates with nigrostriatal dopamine transporter binding in patients with Parkinson 's _ disease .
3474033	0	apomorphine	27,38	Growth_hormone	0,14	apomorphine	Growth hormone	MESH:D001058	2688	Chemical	Gene	patterns|compound|START_ENTITY END_ENTITY|nmod|patterns	Growth_hormone response to apomorphine and family patterns of illness .
3697435	0	apomorphine	27,38	Growth_hormone	0,14	apomorphine	Growth hormone	MESH:D001058	2688	Chemical	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Growth_hormone response to apomorphine and diagnosis : a comparison of three diagnostic systems .
8527467	0	apomorphine	27,38	Growth_hormone	0,14	apomorphine	Growth hormone	MESH:D001058	2688	Chemical	Gene	response|acl|START_ENTITY response|amod|END_ENTITY	Growth_hormone response to apomorphine in panic_disorder : comparison with major depression and normal controls .
10216178	0	apomorphine	118,129	c-Fos	39,44	apomorphine	c-Fos	MESH:D001058	314322(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY striatum|nmod|treatment changes|nmod|striatum changes|nmod|END_ENTITY	Compartmental changes in expression of c-Fos and FosB proteins in intact and dopamine-depleted striatum after chronic apomorphine treatment .
16979142	0	apomorphine	15,26	c-Fos	57,62	apomorphine	c-Fos	MESH:D001058	314322(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|amod|END_ENTITY	The effects of apomorphine and D-amphetamine on striatal c-Fos expression in Sprague-Dawley and Long Evans rats and their F1 progeny .
8298093	0	apomorphine	26,37	c-fos	0,5	apomorphine	c-fos	MESH:D001058	314322(Tax:10116)	Chemical	Gene	rotation|amod|START_ENTITY generates|dobj|rotation generates|nsubj|antisense antisense|amod|END_ENTITY	c-fos antisense generates apomorphine and amphetamine-induced rotation .
2888024	0	apomorphine	78,89	gastrin	44,51	apomorphine	gastrin	MESH:D001058	100685087	Chemical	Gene	Effects|acl|START_ENTITY Effects|nmod|antagonists antagonists|nmod|responses responses|compound|END_ENTITY	Effects of dopamine receptor antagonists on gastrin and vomiting responses to apomorphine .
3627288	0	apomorphine	35,46	gastrin	15,22	apomorphine	gastrin	MESH:D001058	100685087	Chemical	Gene	response|acl|START_ENTITY response|compound|END_ENTITY	A long lasting gastrin response to apomorphine revealed by inhibitors of gastric_acid secretion .
7032213	0	apomorphine	10,21	gastrin	43,50	apomorphine	gastrin	MESH:D001058	100685087	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of apomorphine on peripheral venous gastrin and insulin levels in conscious dogs .
7145038	0	apomorphine	11,22	glutamate_decarboxylase	26,49	apomorphine	glutamate decarboxylase	MESH:D001058	396489(Tax:9031)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|amod|END_ENTITY	Effects of apomorphine on glutamate_decarboxylase activity in chick paleostriatum augmentatum .
11176962	0	apomorphine	37,48	growth_hormone	10,24	apomorphine	growth hormone	MESH:D001058	2688	Chemical	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Increased growth_hormone response to apomorphine in Parkinson_disease compared with multiple_system_atrophy .
1149303	0	apomorphine	28,39	growth_hormone	60,74	apomorphine	growth hormone	MESH:D001058	2688	Chemical	Gene	effect|nmod|START_ENTITY Comparison|nmod|effect END_ENTITY|nsubj|Comparison	Comparison of the effect of apomorphine and L-DOPA on serum growth_hormone levels in normal men .
1242266	0	apomorphine	36,47	growth_hormone	56,70	apomorphine	growth hormone	MESH:D001058	2688	Chemical	Gene	Lack|nmod|START_ENTITY Lack|acl|induced induced|dobj|release release|amod|END_ENTITY	Lack of effect of hyperglycaemia on apomorphine induced growth_hormone release in normal man .
12914551	0	apomorphine	41,52	growth_hormone	65,79	apomorphine	growth hormone	MESH:D001058	2688	Chemical	Gene	effect|nmod:poss|START_ENTITY study|nmod|effect study|nmod|secretion secretion|amod|END_ENTITY	Pharmacokinetic-pharmacodynamic study of apomorphine 's effect on growth_hormone secretion in healthy subjects .
1871327	0	apomorphine	98,109	growth_hormone	40,54	apomorphine	growth hormone	MESH:D001058	2688	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|methyltestosterone methyltestosterone|nmod|response response|amod|END_ENTITY	The effect of methyltestosterone on the growth_hormone response to the dopamine receptor agonist , apomorphine .
1930878	0	apomorphine	84,95	growth_hormone	57,71	apomorphine	growth hormone	MESH:D001058	2688	Chemical	Gene	mediating|advcl|START_ENTITY mediating|dobj|response response|amod|END_ENTITY	Stereospecificity of the dopamine receptor mediating the growth_hormone response to apomorphine in man .
6120733	2	apomorphine	116,127	growth_hormone	74,88	apomorphine	growth hormone	MESH:D001058	2688	Chemical	Gene	responses|acl|START_ENTITY END_ENTITY|dobj|responses	Plasma growth_hormone and prolactin responses to apomorphine .
6436869	0	apomorphine	72,83	growth_hormone	45,59	apomorphine	growth hormone	MESH:D001058	2688	Chemical	Gene	effect|acl|START_ENTITY effect|nmod|treatment treatment|nmod|response response|amod|END_ENTITY	The effect of amitriptyline treatment on the growth_hormone response to apomorphine .
6497565	1	apomorphine	107,118	growth_hormone	80,94	apomorphine	growth hormone	MESH:D001058	2688	Chemical	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	An association with increased growth_hormone response to apomorphine .
7566518	0	apomorphine	76,87	growth_hormone	49,63	apomorphine	growth hormone	MESH:D001058	2688	Chemical	Gene	Effect|acl|START_ENTITY Effect|nmod|therapy therapy|nmod|response response|amod|END_ENTITY	Effect of previous antidepressant therapy on the growth_hormone response to apomorphine .
8820174	0	apomorphine	101,112	growth_hormone	74,88	apomorphine	growth hormone	MESH:D001058	2688	Chemical	Gene	effect|acl|START_ENTITY effect|nmod|response response|amod|END_ENTITY	The effect of Yohimbine , an alpha2 adrenergic receptor antagonist , on the growth_hormone response to apomorphine in normal subjects .
8829723	1	apomorphine	100,111	growth_hormone	73,87	apomorphine	growth hormone	MESH:D001058	2688	Chemical	Gene	study|acl|START_ENTITY study|nmod|response response|amod|END_ENTITY	A study of the growth_hormone response to apomorphine .
8897112	0	apomorphine	31,42	growth_hormone	4,18	apomorphine	growth hormone	MESH:D001058	2688	Chemical	Gene	response|acl|START_ENTITY response|amod|END_ENTITY	The growth_hormone response to apomorphine at 4 days postpartum in women with a history of major_depression .
9359974	0	apomorphine	79,90	growth_hormone	52,66	apomorphine	growth hormone	MESH:D001058	2688	Chemical	Gene	response|acl|START_ENTITY response|amod|END_ENTITY	Dopamine function in obsessive-compulsive_disorder : growth_hormone response to apomorphine stimulation .
9789204	0	apomorphine	55,66	growth_hormone	21,35	apomorphine	growth hormone	MESH:D001058	2688	Chemical	Gene	response|nmod|START_ENTITY response|nmod|doses doses|amod|graded graded|amod|END_ENTITY	Elevated response of growth_hormone to graded doses of apomorphine in schizophrenic patients .
993808	0	apomorphine	10,21	growth_hormone	25,39	apomorphine	growth hormone	MESH:D001058	2688	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Effect of apomorphine on growth_hormone and prolactin secretion in schizophrenic patients , with or without oral_dyskinesia , withdrawn from chronic neuroleptic therapy .
1087036	0	apomorphine	10,21	prolactin	57,66	apomorphine	prolactin	MESH:D001058	24683(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|compound|END_ENTITY	Effect of apomorphine plus 5-hydroxytryptophan on plasma prolactin levels in male rats .
1179038	0	apomorphine	10,21	prolactin	31,40	apomorphine	prolactin	MESH:D001058	24683(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|level level|compound|END_ENTITY	Effect of apomorphine on serum prolactin level in the male .
2314128	0	apomorphine	22,33	prolactin	73,82	apomorphine	prolactin	MESH:D001058	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|ultrastructure ultrastructure|nmod|cells cells|compound|END_ENTITY	The effect of chronic apomorphine treatment on the ultrastructure of the prolactin cells and on plasma prolactin levels in young and aged male Wistar_rats .
7301038	5	apomorphine	709,720	prolactin	729,738	apomorphine	prolactin	MESH:D001058	24683(Tax:10116)	Chemical	Gene	reduced|nsubj|START_ENTITY reduced|dobj|levels levels|compound|END_ENTITY	Injections of L-DOPA lowered prolactin in young but not in old rats , while apomorphine reduced prolactin levels in both groups .
17719177	0	apomorphine	10,21	synaptotagmin_7	34,49	apomorphine	synaptotagmin 7	MESH:D001058	59267(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|amod|END_ENTITY	Effect of apomorphine on striatal synaptotagmin_7 mRNA levels in reserpinized rats .
6281836	0	apomorphine	78,89	thyrotropin_releasing_hormone	28,57	apomorphine	thyrotropin releasing hormone	MESH:D001058	22044(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nmod|END_ENTITY	Jumping behavior induced by thyrotropin_releasing_hormone in combination with apomorphine in mice .
6137249	0	apomorphine_HCl	44,59	Growth_hormone	0,14	apomorphine HCl	Growth hormone	CHEBI:31228	2688	Chemical	Gene	responses|nmod|START_ENTITY responses|amod|END_ENTITY	Growth_hormone responses to graded doses of apomorphine_HCl in schizophrenia .
11488464	0	aporphine	61,70	platelet-activating_factor_receptor	14,49	aporphine	platelet-activating factor receptor	MESH:C081279	100354046(Tax:9986)	Chemical	Gene	binding|nmod|START_ENTITY binding|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of platelet-activating_factor_receptor binding by aporphine and phenanthrenoid_alkaloids from Aromadendron elegans .
25530115	0	apremilast	20,30	PDE4	4,8	apremilast	PDE4	MESH:C505730	5141	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	The PDE4 inhibitor , apremilast , suppresses experimentally induced alopecia areata in human skin in vivo .
22678114	0	apricoxib	85,94	COX-2	65,70	apricoxib	COX-2	MESH:C514354	5743	Chemical	Gene	increases|nmod|START_ENTITY increases|nmod|inhibition inhibition|compound|END_ENTITY	Epithelial-mesenchymal transition increases tumor sensitivity to COX-2 inhibition by apricoxib .
15262827	0	aprotinin	87,96	PAR1	66,70	aprotinin	PAR1	null	2149	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|appos|END_ENTITY	Clinical inhibition of the seven-transmembrane thrombin receptor -LRB- PAR1 -RRB- by intravenous aprotinin during cardiothoracic surgery .
12212211	0	aprotinin	12,21	TNF-alpha	25,34	aprotinin	TNF-alpha	null	7124	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|amod|END_ENTITY	-LSB- Effects of aprotinin on TNF-alpha levels after cardiopulmonary bypass -RSB- .
10547191	0	aprotinin	98,107	Tissue_kallikrein	0,17	aprotinin	Tissue kallikrein	null	3816	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|END_ENTITY	Tissue_kallikrein in severe acute pancreatitis in patients treated with high-dose intraperitoneal aprotinin .
14766695	0	aprotinin	45,54	Vasopressin	0,11	aprotinin	Vasopressin	null	551	Chemical	Gene	administration|compound|START_ENTITY END_ENTITY|nmod|administration	Vasopressin for treatment of shock following aprotinin administration .
16146463	0	aprotinin	15,24	thrombin	48,56	aprotinin	thrombin	null	2147	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|generation generation|compound|END_ENTITY	The effects of aprotinin and tranexamic_acid on thrombin generation and fibrinolytic response after cardiac surgery .
3473678	0	ara-CMP	38,45	DNA_polymerase-alpha	14,34	ara-CMP	DNA polymerase-alpha	null	5422	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of DNA_polymerase-alpha by ara-CMP in the presence of a regulatory protein extracted from human promyelocytic leukemic cells -LRB- HL-60 -RRB- .
1367649	0	arabinofuranose	22,37	O-2	15,18	arabinofuranose	O-2	MESH:C431714	28893	Chemical	Gene	residues|amod|START_ENTITY END_ENTITY|nmod|residues	Acetylation at O-2 of arabinofuranose residues in feruloylated arabinoxylan from bamboo shoot cell-walls .
2124813	0	arabinofuranosylcytosine	38,62	c-fos	13,18	arabinofuranosylcytosine	c-fos	MESH:D003561	2353	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Induction of c-fos gene expression by arabinofuranosylcytosine in human KG-1 leukemia cells .
2122980	0	arabinofuranosylcytosine	55,79	c-jun	30,35	arabinofuranosylcytosine	c-jun	MESH:D003561	3725	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Transcriptional regulation of c-jun gene expression by arabinofuranosylcytosine in human myeloid_leukemia cells .
10344205	0	arabinose	4,13	ARA1	22,26	arabinose	ARA1	MESH:D001089	827299(Tax:3702)	Chemical	Gene	gene|amod|START_ENTITY gene|dep|END_ENTITY	The arabinose kinase , ARA1 , gene of Arabidopsis is a novel member of the galactose kinase gene family .
8090026	0	arabinosylcytosine_triphosphate	80,111	granulocyte-macrophage_colony-stimulating_factor	10,58	arabinosylcytosine triphosphate	granulocyte-macrophage colony-stimulating factor	MESH:D001085	1437	Chemical	Gene	metabolism|nmod|START_ENTITY Effect|nmod|metabolism Effect|nmod|END_ENTITY	Effect of granulocyte-macrophage_colony-stimulating_factor on the metabolism of arabinosylcytosine_triphosphate in blasts during therapy of patients with chronic_myelogenous_leukemia .
2127729	0	arachidonate	19,31	5-lipoxygenase	55,69	arachidonate	5-lipoxygenase	CHEBI:32395	240	Chemical	Gene	START_ENTITY|nmod|biosynthesis biosynthesis|nmod|metabolites metabolites|amod|END_ENTITY	-LSB- Role of exogenous arachidonate in the biosynthesis of 5-lipoxygenase metabolites of arachidonic_acid by human polymorphonuclear leukocytes induced by the calcium ionophore A23187 -RSB- .
2539060	0	arachidonate	75,87	5-lipoxygenase	96,110	arachidonate	5-lipoxygenase	CHEBI:32395	240	Chemical	Gene	START_ENTITY|nmod|pathway pathway|amod|END_ENTITY	Inhibition of human neutrophils by auranofin : chemotaxis and metabolism of arachidonate via the 5-lipoxygenase pathway .
2109933	0	arachidonate	17,29	Cytochrome_P-450	0,16	arachidonate	Cytochrome P-450	CHEBI:32395	25251(Tax:10116)	Chemical	Gene	metabolites|compound|START_ENTITY metabolites|amod|END_ENTITY	Cytochrome_P-450 arachidonate metabolites in rat kidney : characterization and hemodynamic responses .
2867452	0	arachidonate	53,65	Growth_hormone_releasing_factor	0,31	arachidonate	Growth hormone releasing factor	CHEBI:32395	2691	Chemical	Gene	levels|compound|START_ENTITY increases|dobj|levels increases|nsubj|END_ENTITY	Growth_hormone_releasing_factor -LRB- GRF -RRB- increases free arachidonate levels in the pituitary : a role for lipoxygenase products .
3145981	0	arachidonate	39,51	Nerve_growth_factor	0,19	arachidonate	Nerve growth factor	CHEBI:32395	310738(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY stimulates|dobj|metabolism stimulates|nsubj|END_ENTITY	Nerve_growth_factor rapidly stimulates arachidonate metabolism in PC12 cells : potential involvement in nerve fiber growth .
3102391	0	arachidonate	20,32	Thrombin	0,8	arachidonate	Thrombin	CHEBI:32395	14061(Tax:10090)	Chemical	Gene	metabolism|amod|START_ENTITY stimulates|dobj|metabolism stimulates|nsubj|END_ENTITY	Thrombin stimulates arachidonate metabolism in murine tumor cells .
3931645	0	arachidonate	32,44	angiotensin_II	14,28	arachidonate	angiotensin II	CHEBI:32395	24179(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY END_ENTITY|nmod|metabolism	The effect of angiotensin_II on arachidonate metabolism in adrenal glomerulosa cells .
17084455	0	arachidonate	45,57	beta-glucan_receptor	15,35	arachidonate	beta-glucan receptor	CHEBI:32395	56644(Tax:10090)	Chemical	Gene	release|compound|START_ENTITY release|amod|END_ENTITY	The macrophage beta-glucan_receptor mediates arachidonate release induced by zymosan : essential role for Src family kinases .
18606824	0	arachidonate	51,63	cytochrome_p450	35,50	arachidonate	cytochrome p450	CHEBI:32395	4051	Chemical	Gene	metabolites|compound|START_ENTITY metabolites|amod|END_ENTITY	Identification of novel endogenous cytochrome_p450 arachidonate metabolites with high affinity for cannabinoid receptors .
3143745	0	arachidonate	71,83	interleukin_2	37,50	arachidonate	interleukin 2	CHEBI:32395	3558	Chemical	Gene	metabolism|compound|START_ENTITY Influence|nmod|metabolism Influence|nmod|END_ENTITY	Influence of natural and recombinant interleukin_2 on endothelial cell arachidonate metabolism .
6429141	0	arachidonate	50,62	thrombin	114,122	arachidonate	thrombin	CHEBI:32395	2147	Chemical	Gene	metabolism|amod|START_ENTITY dissociated|nmod|metabolism dissociated|nmod|change change|acl|induced induced|nmod|factor factor|compound|END_ENTITY	Activation of phospholipase C is dissociated from arachidonate metabolism during platelet shape change induced by thrombin or platelet-activating factor .
7410346	0	arachidonate	41,53	thrombin	29,37	arachidonate	thrombin	CHEBI:32395	2147	Chemical	Gene	metabolism|amod|START_ENTITY END_ENTITY|nmod|metabolism	Evidence that the effects of thrombin on arachidonate metabolism in cultured human endothelial cells are not mediated by a high affinity receptor .
16653144	0	arachidonic_Acid	78,94	5-lipoxygenase	21,35	arachidonic Acid	5-lipoxygenase	MESH:D016718	102577615	Chemical	Gene	START_ENTITY|nsubj|stimulation stimulation|nmod|activity activity|amod|END_ENTITY	Rapid stimulation of 5-lipoxygenase activity in potato by the fungal elicitor arachidonic_Acid .
3922792	0	arachidonic_acid	17,33	15-lipoxygenase	34,49	arachidonic acid	15-lipoxygenase	MESH:D016718	246	Chemical	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	Appearance of an arachidonic_acid 15-lipoxygenase pathway upon differentiation of the human promyelocytic cell-line HL-60 .
8810309	0	arachidonic_acid	13,29	15-lipoxygenase	52,67	arachidonic acid	15-lipoxygenase	MESH:D016718	246	Chemical	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Defining the arachidonic_acid binding site of human 15-lipoxygenase .
9475159	0	arachidonic_acid	19,35	17beta-hydroxysteroid_dehydrogenase	39,74	arachidonic acid	17beta-hydroxysteroid dehydrogenase	MESH:D016718	364773(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|cells cells|amod|END_ENTITY	Specific effect of arachidonic_acid on 17beta-hydroxysteroid_dehydrogenase in rat Leydig cells .
9263885	0	arachidonic_acid	30,46	5-Lipoxygenase	0,14	arachidonic acid	5-Lipoxygenase	MESH:D016718	240	Chemical	Gene	metabolites|nmod|START_ENTITY metabolites|amod|END_ENTITY	5-Lipoxygenase metabolites of arachidonic_acid regulate volume decrease by mudpuppy red blood cells .
12525578	0	arachidonic_acid	52,68	5-lipoxygenase	34,48	arachidonic acid	5-lipoxygenase	MESH:D016718	240	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Cell type-dependent activation of 5-lipoxygenase by arachidonic_acid .
12943700	0	arachidonic_acid	45,61	5-lipoxygenase	15,29	arachidonic acid	5-lipoxygenase	MESH:D016718	240	Chemical	Gene	expression|amod|START_ENTITY Involvement|nmod|expression Involvement|nmod|metabolites metabolites|amod|END_ENTITY	Involvement of 5-lipoxygenase metabolites of arachidonic_acid in cyclic_AMP-stimulated steroidogenesis and steroidogenic_acute_regulatory protein gene expression .
1329972	0	arachidonic_acid	39,55	5-lipoxygenase	90,104	arachidonic acid	5-lipoxygenase	MESH:D016718	240	Chemical	Gene	START_ENTITY|nmod|neutrophil neutrophil|nmod|formation formation|nmod|products products|amod|END_ENTITY	Time-dependent utilization of platelet arachidonic_acid by the neutrophil in formation of 5-lipoxygenase products in platelet-neutrophil co-incubations .
1898346	0	arachidonic_acid	45,61	5-lipoxygenase	125,139	arachidonic acid	5-lipoxygenase	MESH:D016718	25290(Tax:10116)	Chemical	Gene	acid|amod|START_ENTITY acid|nmod|substrates substrates|nmod|END_ENTITY	Evaluation of 5 - _ and_6-fluoro derivatives of arachidonic_acid and 5,8,14-eicosatrienoic _ acid as substrates and inhibitors of 5-lipoxygenase .
1906918	0	arachidonic_acid	35,51	5-lipoxygenase	8,22	arachidonic acid	5-lipoxygenase	MESH:D016718	25290(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|products products|amod|END_ENTITY	Role of 5-lipoxygenase products of arachidonic_acid in cell-to-cell interaction between macrophages and natural killer cells in rat spleen .
1907824	0	arachidonic_acid	166,182	5-lipoxygenase	108,122	arachidonic acid	5-lipoxygenase	MESH:D016718	240	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|amod|END_ENTITY	Pharmacology of the pyrroloimidazole , SK_F 105809 -- I. Inhibition of inflammatory cytokine production and of 5-lipoxygenase - and cyclooxygenase-mediated metabolism of arachidonic_acid .
19336727	0	arachidonic_acid	128,144	5-lipoxygenase	154,168	arachidonic acid	5-lipoxygenase	MESH:D016718	240	Chemical	Gene	START_ENTITY|nmod|pathway pathway|amod|END_ENTITY	Levels of prostaglandin_E metabolite and leukotriene_E -LRB- 4 -RRB- are increased in the urine of smokers : evidence that celecoxib shunts arachidonic_acid into the 5-lipoxygenase pathway .
20880396	0	arachidonic_acid	95,111	5-lipoxygenase	4,18	arachidonic acid	5-lipoxygenase	MESH:D016718	240	Chemical	Gene	release|amod|START_ENTITY inhibition|nmod|release suppresses|nmod|inhibition suppresses|nsubj|inhibitor inhibitor|amod|END_ENTITY	The 5-lipoxygenase inhibitor , zileuton , suppresses prostaglandin biosynthesis by inhibition of arachidonic_acid release in macrophages .
2127729	0	arachidonic_acid	85,101	5-lipoxygenase	55,69	arachidonic acid	5-lipoxygenase	MESH:D016718	240	Chemical	Gene	-RSB-|amod|START_ENTITY metabolites|nmod|-RSB- metabolites|amod|END_ENTITY	-LSB- Role of exogenous arachidonate in the biosynthesis of 5-lipoxygenase metabolites of arachidonic_acid by human polymorphonuclear leukocytes induced by the calcium ionophore A23187 -RSB- .
21656078	0	arachidonic_acid	16,32	5-lipoxygenase	47,61	arachidonic acid	5-lipoxygenase	MESH:D016718	240	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|nmod|epoxygenase epoxygenase|amod|END_ENTITY	The shunting of arachidonic_acid metabolism to 5-lipoxygenase and cytochrome p450 epoxygenase antagonizes the anti-cancer effect of cyclooxygenase-2 inhibition in head_and_neck_cancer cells .
21881027	0	arachidonic_acid	108,124	5-lipoxygenase	82,96	arachidonic acid	5-lipoxygenase	MESH:D016718	11689(Tax:10090)	Chemical	Gene	metabolism|amod|START_ENTITY pathway|nmod|metabolism pathway|amod|END_ENTITY	Ethanol promotes chemically induced oral_cancer in mice through activation of the 5-lipoxygenase pathway of arachidonic_acid metabolism .
23351835	0	arachidonic_acid	15,31	5-lipoxygenase	77,91	arachidonic acid	5-lipoxygenase	MESH:D016718	240	Chemical	Gene	START_ENTITY|ccomp|associated associated|nmod|expression expression|nmod|END_ENTITY	Adipose tissue arachidonic_acid content is associated with the expression of 5-lipoxygenase in atherosclerotic plaques .
24893149	0	arachidonic_acid	77,93	5-lipoxygenase	39,53	arachidonic acid	5-lipoxygenase	MESH:D016718	240	Chemical	Gene	mechanism|nmod|START_ENTITY mechanism|amod|END_ENTITY	ATP allosterically activates the human 5-lipoxygenase molecular mechanism of arachidonic_acid and 5 -LRB- S -RRB- - hydroperoxy-6 -LRB- E -RRB- ,8 -LRB- Z -RRB- ,11 -LRB- Z -RRB- ,14 -LRB- Z -RRB- - eicosatetraenoic_acid .
2507084	0	arachidonic_acid	63,79	5-lipoxygenase	35,49	arachidonic acid	5-lipoxygenase	MESH:D016718	240	Chemical	Gene	exogenous|acl|START_ENTITY END_ENTITY|nmod|exogenous	Activation of the human neutrophil 5-lipoxygenase by exogenous arachidonic_acid : involvement of pertussis toxin-sensitive guanine_nucleotide-binding proteins .
2603790	0	arachidonic_acid	63,79	5-lipoxygenase	33,47	arachidonic acid	5-lipoxygenase	MESH:D016718	240	Chemical	Gene	capacity|acl|START_ENTITY capacity|nmod|metabolites metabolites|amod|END_ENTITY	Neutrophil producing capacity of 5-lipoxygenase metabolites of arachidonic_acid after major surgery .
2835319	0	arachidonic_acid	41,57	5-lipoxygenase	80,94	arachidonic acid	5-lipoxygenase	MESH:D016718	240	Chemical	Gene	START_ENTITY|nmod|pathway pathway|amod|END_ENTITY	Intracellular cold trapping of exogenous arachidonic_acid and activation of the 5-lipoxygenase pathway of human neutrophils .
2844895	0	arachidonic_acid	14,30	5-lipoxygenase	43,57	arachidonic acid	5-lipoxygenase	MESH:D016718	240	Chemical	Gene	START_ENTITY|nmod|pathway pathway|amod|END_ENTITY	Metabolism of arachidonic_acid through the 5-lipoxygenase pathway in normal human peritoneal macrophages .
2882965	0	arachidonic_acid	40,56	5-lipoxygenase	14,28	arachidonic acid	5-lipoxygenase	MESH:D016718	240	Chemical	Gene	metabolism|amod|START_ENTITY Inhibition|nmod|metabolism Inhibition|nmod|pathway pathway|amod|END_ENTITY	Inhibition of 5-lipoxygenase pathway of arachidonic_acid metabolism in human neutrophils by sulfasalazine and 5-aminosalicylic_acid .
3096328	0	arachidonic_acid	46,62	5-lipoxygenase	85,99	arachidonic acid	5-lipoxygenase	MESH:D016718	240	Chemical	Gene	penetration|nmod|START_ENTITY penetration|nmod|pathway pathway|amod|END_ENTITY	Ethanol-enhanced transmembrane penetration of arachidonic_acid and activation of the 5-lipoxygenase pathway in human leukocytes .
3126237	0	arachidonic_acid	31,47	5-lipoxygenase	71,85	arachidonic acid	5-lipoxygenase	MESH:D016718	25290(Tax:10116)	Chemical	Gene	exogenous|acl|START_ENTITY effect|nmod|exogenous macrophage|nsubj|effect macrophage|dobj|metabolism metabolism|amod|END_ENTITY	Inhibitory effect of exogenous arachidonic_acid on alveolar macrophage 5-lipoxygenase metabolism .
6324236	0	arachidonic_acid	54,70	5-lipoxygenase	24,38	arachidonic acid	5-lipoxygenase	MESH:D016718	240	Chemical	Gene	metabolites|nmod|START_ENTITY metabolites|amod|END_ENTITY	Stable isotope labelled 5-lipoxygenase metabolites of arachidonic_acid : analysis by negative ion chemical ionization mass spectrometry .
7690833	0	arachidonic_acid	137,153	5-lipoxygenase	100,114	arachidonic acid	5-lipoxygenase	MESH:D016718	240	Chemical	Gene	availability|amod|START_ENTITY enhancing|dobj|availability products|acl|enhancing products|amod|END_ENTITY	Lipopolysaccharides prime whole human blood and isolated neutrophils for the increased synthesis of 5-lipoxygenase products by enhancing arachidonic_acid availability : involvement of the CD14 antigen .
7855310	0	arachidonic_acid	37,53	5-lipoxygenase	8,22	arachidonic acid	5-lipoxygenase	MESH:D016718	25290(Tax:10116)	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|amod|END_ENTITY	Reduced 5-lipoxygenase metabolism of arachidonic_acid in macrophages rrom 1,25-dihydroxyvitamin _ D3-deficient rats .
8344271	0	arachidonic_acid	64,80	5-lipoxygenase	84,98	arachidonic acid	5-lipoxygenase	MESH:D016718	240	Chemical	Gene	utilization|nmod|START_ENTITY stimulates|dobj|utilization stimulates|advcl|END_ENTITY	5-lipoxygenase-activating protein stimulates the utilization of arachidonic_acid by 5-lipoxygenase .
8381676	0	arachidonic_acid	100,116	5-lipoxygenase	70,84	arachidonic acid	5-lipoxygenase	MESH:D016718	240	Chemical	Gene	metabolites|nmod|START_ENTITY metabolites|amod|END_ENTITY	Collision-induced dissociation of carboxylate anions from derivatized 5-lipoxygenase metabolites of arachidonic_acid .
8626407	2	arachidonic_acid	441,457	5-lipoxygenase	509,523	arachidonic acid	5-lipoxygenase	MESH:D016718	240	Chemical	Gene	START_ENTITY|xcomp|indicating indicating|ccomp|modulated modulated|dobj|activity activity|amod|END_ENTITY	Six separate inhibitors of tyrosine_kinase each inhibited 5 -LRB- S -RRB- - hydroxyeicosatetraenoic_acid formation by HL-60 cells stimulated with calcium ionophore , in the presence or absence of exogenous arachidonic_acid substrate , indicating that they modulated cellular 5-lipoxygenase activity .
2111085	0	arachidonic_acid	52,68	AD6	24,27	arachidonic acid	AD6	MESH:D016718	64851	Chemical	Gene	release|nmod|START_ENTITY inhibits|dobj|release inhibits|nsubj|END_ENTITY	The coumarin derivative AD6 inhibits the release of arachidonic_acid by interfering with phospholipase_A2 activity in human platelets stimulated with thrombin .
3116710	0	arachidonic_acid	113,129	AD6	0,3	arachidonic acid	AD6	MESH:D016718	64851	Chemical	Gene	release|nmod|START_ENTITY inhibits|dobj|release inhibits|nsubj|END_ENTITY	AD6 -LRB- 8-monochloro-3-beta-diethylamino-ethyl-4-methyl-7-ethoxycarbonyl-meth_oxy_coumarin -RRB- inhibits the release of arachidonic_acid in human platelets stimulated by thrombin .
6425863	0	arachidonic_acid	34,50	Albumin	0,7	arachidonic acid	Albumin	MESH:D016718	213	Chemical	Gene	release|nmod|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Albumin stimulates the release of arachidonic_acid from phosphatidylcholine in hamster lungs .
11532971	0	arachidonic_acid	52,68	Angiotensin_II	0,14	arachidonic acid	Angiotensin II	MESH:D016718	183	Chemical	Gene	Akt/protein|nmod|START_ENTITY Akt/protein|compound|END_ENTITY	Angiotensin_II activates Akt/protein _ kinase_B by an arachidonic_acid / redox-dependent pathway and independent of phosphoinositide_3-kinase .
15803435	0	arachidonic_acid	26,42	Angiotensin_II	0,14	arachidonic acid	Angiotensin II	MESH:D016718	183	Chemical	Gene	START_ENTITY|nsubj|stimulates stimulates|compound|END_ENTITY	Angiotensin_II stimulates arachidonic_acid release from bone marrow stromal cells .
19509298	0	arachidonic_acid	64,80	ApoE	142,146	arachidonic acid	ApoE	MESH:D016718	11816(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Dual 12/15 - and 5-lipoxygenase deficiency in macrophages alters arachidonic_acid metabolism and attenuates_peritonitis and atherosclerosis in ApoE knock-out mice .
14702425	0	arachidonic_acid	55,71	Arachidonate_5-lipoxygenase	0,27	arachidonic acid	Arachidonate 5-lipoxygenase	MESH:D016718	240	Chemical	Gene	START_ENTITY|nsubj|genotype genotype|amod|END_ENTITY	Arachidonate_5-lipoxygenase promoter genotype , dietary arachidonic_acid , and atherosclerosis .
1737988	0	arachidonic_acid	22,38	Bradykinin	0,10	arachidonic acid	Bradykinin	MESH:D016718	3827	Chemical	Gene	START_ENTITY|nsubj|stimulates stimulates|compound|END_ENTITY	Bradykinin stimulates arachidonic_acid release through the sequential actions of an sn-1 diacylglycerol lipase and a monoacylglycerol_lipase .
8062861	0	arachidonic_acid	45,61	Bradykinin	0,10	arachidonic acid	Bradykinin	MESH:D016718	3827	Chemical	Gene	release|nmod|START_ENTITY stimulate|dobj|release stimulate|nsubj|END_ENTITY	Bradykinin and thrombin stimulate release of arachidonic_acid and formation of prostanoids in human periodontal ligament cells .
2497498	0	arachidonic_acid	15,31	CCl4	46,50	arachidonic acid	CCl4	MESH:D016718	116637(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|nmod|END_ENTITY	Stimulation of arachidonic_acid metabolism by CCl4 in isolated rat hepatocytes .
15161995	0	arachidonic_acid	104,120	COX-1	10,15	arachidonic acid	COX-1	MESH:D016718	804478(Tax:9615)	Chemical	Gene	inhibition|nmod|START_ENTITY Effect|dep|inhibition Effect|nmod|END_ENTITY	Effect of COX-1 / COX-2 inhibition versus selective COX-2 inhibition on coronary vasodilator responses to arachidonic_acid and acetylcholine .
15863457	0	arachidonic_acid	42,58	COX-1	62,67	arachidonic acid	COX-1	MESH:D016718	17708(Tax:10090)	Chemical	Gene	generated|nmod|START_ENTITY generated|nmod|END_ENTITY	Vasoactive prostanoids are generated from arachidonic_acid by COX-1 and COX-2 in the mouse .
16519514	0	arachidonic_acid	34,50	COX-1	66,71	arachidonic acid	COX-1	MESH:D016718	4512	Chemical	Gene	complexes|amod|START_ENTITY complexes|nmod|END_ENTITY	Molecular dynamics simulations of arachidonic_acid complexes with COX-1 and COX-2 : insights into equilibrium behavior .
20082610	0	arachidonic_acid	8,24	COX-1	40,45	arachidonic acid	COX-1	MESH:D016718	26195(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|nmod|END_ENTITY	Altered arachidonic_acid metabolism via COX-1 and COX-2 contributes to the endothelial dysfunction of penile arteries from obese Zucker rats .
10438506	0	arachidonic_acid	15,31	COX-2	114,119	arachidonic acid	COX-2	MESH:D016718	17709(Tax:10090)	Chemical	Gene	prostaglandin_endoperoxide_synthase-2|amod|START_ENTITY prostaglandin_endoperoxide_synthase-2|appos|END_ENTITY	The binding of arachidonic_acid in the cyclooxygenase active site of mouse prostaglandin_endoperoxide_synthase-2 -LRB- COX-2 -RRB- .
12900435	0	arachidonic_acid	56,72	COX-2	8,13	arachidonic acid	COX-2	MESH:D016718	26198(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY Role|nmod|effect Role|nmod|END_ENTITY	Role of COX-2 in the enhanced vasoconstrictor effect of arachidonic_acid in the diabetic rat kidney .
15161995	0	arachidonic_acid	104,120	COX-2	16,21	arachidonic acid	COX-2	MESH:D016718	804479(Tax:9615)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Effect of COX-1 / COX-2 inhibition versus selective COX-2 inhibition on coronary vasodilator responses to arachidonic_acid and acetylcholine .
15161995	0	arachidonic_acid	104,120	COX-2	50,55	arachidonic acid	COX-2	MESH:D016718	804479(Tax:9615)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|inhibition inhibition|compound|END_ENTITY	Effect of COX-1 / COX-2 inhibition versus selective COX-2 inhibition on coronary vasodilator responses to arachidonic_acid and acetylcholine .
19603831	0	arachidonic_acid	77,93	COX-2	56,61	arachidonic acid	COX-2	MESH:D016718	5743	Chemical	Gene	oxygenation|acl|START_ENTITY oxygenation|compound|END_ENTITY	Differential sensitivity and mechanism of inhibition of COX-2 oxygenation of arachidonic_acid and 2-arachidonoylglycerol by ibuprofen and mefenamic_acid .
1532099	0	arachidonic_acid	29,45	CSF-1	241,246	arachidonic acid	CSF-1	MESH:D016718	12977(Tax:10090)	Chemical	Gene	metabolism|amod|START_ENTITY signal|nmod|metabolism Transduction|nmod|signal induces|nsubj|Transduction induces|nmod|that that|acl|induced induced|nmod|END_ENTITY	Transduction of a signal for arachidonic_acid metabolism by untriggered CSF-1_receptor induces an opposite effect to that induced by CSF-1_receptor and its ligand : separate regulation of phospholipase A2 and cyclooxygenase by CSF-1_receptor / CSF-1 .
1532099	0	arachidonic_acid	29,45	CSF-1_receptor	133,147	arachidonic acid	CSF-1 receptor	MESH:D016718	12978(Tax:10090)	Chemical	Gene	metabolism|amod|START_ENTITY signal|nmod|metabolism Transduction|nmod|signal induces|nsubj|Transduction induces|nmod|that that|acl|induced induced|nmod|END_ENTITY	Transduction of a signal for arachidonic_acid metabolism by untriggered CSF-1_receptor induces an opposite effect to that induced by CSF-1_receptor and its ligand : separate regulation of phospholipase A2 and cyclooxygenase by CSF-1_receptor / CSF-1 .
1532099	0	arachidonic_acid	29,45	CSF-1_receptor	226,240	arachidonic acid	CSF-1 receptor	MESH:D016718	12978(Tax:10090)	Chemical	Gene	metabolism|amod|START_ENTITY signal|nmod|metabolism Transduction|nmod|signal induces|nsubj|Transduction induces|nmod|that that|acl|induced induced|nmod|CSF-1 CSF-1|compound|END_ENTITY	Transduction of a signal for arachidonic_acid metabolism by untriggered CSF-1_receptor induces an opposite effect to that induced by CSF-1_receptor and its ligand : separate regulation of phospholipase A2 and cyclooxygenase by CSF-1_receptor / CSF-1 .
1532099	0	arachidonic_acid	29,45	CSF-1_receptor	72,86	arachidonic acid	CSF-1 receptor	MESH:D016718	12978(Tax:10090)	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|nmod|END_ENTITY	Transduction of a signal for arachidonic_acid metabolism by untriggered CSF-1_receptor induces an opposite effect to that induced by CSF-1_receptor and its ligand : separate regulation of phospholipase A2 and cyclooxygenase by CSF-1_receptor / CSF-1 .
8954571	0	arachidonic_acid	75,91	CYP4A2	137,143	arachidonic acid	CYP4A2	MESH:D016718	24306(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	Cloning , sequencing , and cDNA-directed expression of the rat renal CYP4A2 : arachidonic_acid omega-hydroxylation and 11,12-epoxidation by CYP4A2 protein .
12384982	0	arachidonic_acid	45,61	Calcium-independent_phospholipase_A2	0,36	arachidonic acid	Calcium-independent phospholipase A2	MESH:D016718	57104	Chemical	Gene	mobilization|amod|START_ENTITY END_ENTITY|nmod|mobilization	Calcium-independent_phospholipase_A2 through arachidonic_acid mobilization is involved in Caco-2 cell growth .
10096434	0	arachidonic_acid	40,56	Cyclosporin_A	0,13	arachidonic acid	Cyclosporin A	MESH:D016718	1161	Chemical	Gene	release|amod|START_ENTITY increases|dobj|release increases|nsubj|END_ENTITY	Cyclosporin_A , but not FK506 , increases arachidonic_acid release and inhibits proliferation of pituitary_corticotrope_tumor cells .
1905908	0	arachidonic_acid	31,47	Cytochrome_P-450	0,16	arachidonic acid	Cytochrome P-450	MESH:D016718	4051	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|amod|END_ENTITY	Cytochrome_P-450 metabolism of arachidonic_acid .
2124686	0	arachidonic_acid	32,48	Cytochrome_P-450	0,16	arachidonic acid	Cytochrome P-450	MESH:D016718	25251(Tax:10116)	Chemical	Gene	metabolites|nmod|START_ENTITY metabolites|amod|END_ENTITY	Cytochrome_P-450 metabolites of arachidonic_acid : implications for blood pressure regulation .
2358445	0	arachidonic_acid	103,119	Cytochrome_P-450	0,16	arachidonic acid	Cytochrome P-450	MESH:D016718	25251(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|control control|amod|END_ENTITY	Cytochrome_P-450 enzyme-specific control of the regio - and enantiofacial selectivity of the microsomal arachidonic_acid epoxygenase .
10677385	0	arachidonic_acid	31,47	Cytochrome_P450	0,15	arachidonic acid	Cytochrome P450	MESH:D016718	25251(Tax:10116)	Chemical	Gene	metabolites|nmod|START_ENTITY metabolites|amod|END_ENTITY	Cytochrome_P450 metabolites of arachidonic_acid may be important mediators in angiotensin_II-induced vasoconstriction in the rat mesentery in vivo .
11195057	0	arachidonic_acid	31,47	Cytochrome_P450	0,15	arachidonic acid	Cytochrome P450	MESH:D016718	4051	Chemical	Gene	metabolites|nmod|START_ENTITY metabolites|amod|END_ENTITY	Cytochrome_P450 metabolites of arachidonic_acid in the control of renal function .
19302554	0	arachidonic_acid	31,47	Cytochrome_P450	0,15	arachidonic acid	Cytochrome P450	MESH:D016718	25251(Tax:10116)	Chemical	Gene	metabolites|nmod|START_ENTITY metabolites|amod|END_ENTITY	Cytochrome_P450 metabolites of arachidonic_acid play a role in the enhanced cardiac_dysfunction in diabetic rats following ischaemic_reperfusion_injury .
21689071	0	arachidonic_acid	31,47	Cytochrome_P450	0,15	arachidonic acid	Cytochrome P450	MESH:D016718	4051	Chemical	Gene	metabolites|nmod|START_ENTITY metabolites|amod|END_ENTITY	Cytochrome_P450 metabolites of arachidonic_acid are elevated in stroke patients compared with healthy controls .
2556446	0	arachidonic_acid	31,47	Cytochrome_P450	0,15	arachidonic acid	Cytochrome P450	MESH:D016718	100328948(Tax:9986)	Chemical	Gene	metabolites|nmod|START_ENTITY metabolites|amod|END_ENTITY	Cytochrome_P450 metabolites of arachidonic_acid are potent inhibitors of vasopressin action on rabbit cortical collecting duct .
9430380	0	arachidonic_acid	31,47	Cytochrome_P450	0,15	arachidonic acid	Cytochrome P450	MESH:D016718	4051	Chemical	Gene	metabolites|nmod|START_ENTITY metabolites|amod|END_ENTITY	Cytochrome_P450 metabolites of arachidonic_acid : rapid incorporation and hydration of 14,15-epoxyeicosatrienoic _ acid in arterial smooth muscle cells .
9440131	0	arachidonic_acid	31,47	Cytochrome_P450	0,15	arachidonic acid	Cytochrome P450	MESH:D016718	4051	Chemical	Gene	metabolites|nmod|START_ENTITY metabolites|amod|END_ENTITY	Cytochrome_P450 metabolites of arachidonic_acid in human placenta .
1631101	0	arachidonic_acid	73,89	Cytosolic_phospholipase_A2	0,26	arachidonic acid	Cytosolic phospholipase A2	MESH:D016718	5321	Chemical	Gene	release|nmod|START_ENTITY hormonally|dobj|release coupled|xcomp|hormonally coupled|nsubjpass|END_ENTITY	Cytosolic_phospholipase_A2 is coupled to hormonally regulated release of arachidonic_acid .
6416720	0	arachidonic_acid	10,26	E2_and_I2	66,75	arachidonic acid	E2 and I2	MESH:D016718	299201(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	Effect of arachidonic_acid on the basal release of prostaglandins E2_and_I2 by rat arteries during the development of hypertension .
1327266	0	arachidonic_acid	23,39	EDRF	91,95	arachidonic acid	EDRF	MESH:D016718	51327	Chemical	Gene	START_ENTITY|nmod|factor factor|appos|END_ENTITY	Inhibition of platelet arachidonic_acid liberation by endothelium-derived relaxing factor -LRB- EDRF -RRB- as studied with sin-1 , a nitric_oxide generating drug .
1904341	0	arachidonic_acid	39,55	Endothelin-1	0,12	arachidonic acid	Endothelin-1	MESH:D016718	100009270(Tax:9986)	Chemical	Gene	muscle|amod|START_ENTITY release|nmod|muscle stimulates|dobj|release stimulates|nsubj|END_ENTITY	Endothelin-1 stimulates the release of arachidonic_acid and prostaglandins in rabbit iris sphincter smooth muscle : activation of phospholipase A2 .
20846129	0	arachidonic_acid	95,111	Endothelin-1	0,12	arachidonic acid	Endothelin-1	MESH:D016718	1906	Chemical	Gene	metabolites|amod|START_ENTITY mediated|nmod|metabolites mediated|nsubjpass|proliferation proliferation|compound|END_ENTITY	Endothelin-1 induced vascular smooth muscle cell proliferation is mediated by cytochrome_p-450 arachidonic_acid metabolites .
9237867	0	arachidonic_acid	39,55	Endothelin-1	0,12	arachidonic acid	Endothelin-1	MESH:D016718	1906	Chemical	Gene	release|nmod|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Endothelin-1 stimulates the release of arachidonic_acid and prostaglandins in cultured human ciliary muscle cells : activation of phospholipase_A2 .
2511390	0	arachidonic_acid	45,61	Epidermal_growth_factor	0,23	arachidonic acid	Epidermal growth factor	MESH:D016718	1950	Chemical	Gene	release|nmod|START_ENTITY modulates|dobj|release modulates|nsubj|END_ENTITY	Epidermal_growth_factor modulates release of arachidonic_acid from embryonic cells .
8557642	0	arachidonic_acid	39,55	GLUT4	14,19	arachidonic acid	GLUT4	MESH:D016718	20528(Tax:10090)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of GLUT4 gene expression by arachidonic_acid .
3549770	0	arachidonic_acid	18,34	GnRH	50,54	arachidonic acid	GnRH	MESH:D016718	25194(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|action action|compound|END_ENTITY	The role of novel arachidonic_acid metabolites in GnRH action on gonadotrophin release in vitro .
11854839	2	arachidonic_acid	432,448	IL-1beta	399,407	arachidonic acid	Il-1beta	MESH:D016718	3553	Chemical	Gene	START_ENTITY|nsubj|induced induced|amod|END_ENTITY	We found that both IL-1beta and misoprostol induced arachidonic_acid release , suggesting enhanced phospholipase_A -LRB- 2 -RRB- activation .
2762368	0	arachidonic_acid	28,44	Lipoxygenase	0,12	arachidonic acid	Lipoxygenase	MESH:D016718	100009114(Tax:9986)	Chemical	Gene	metabolites|nmod|START_ENTITY metabolites|amod|END_ENTITY	Lipoxygenase metabolites of arachidonic_acid do not induce mucus secretion from rabbit intestinal goblet cells in vitro .
9180273	0	arachidonic_acid	69,85	MRP8	45,49	arachidonic acid	MRP8	MESH:D016718	20201(Tax:10090)	Chemical	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	The heterodimer of the Ca2 + - binding proteins MRP8 and MRP14 binds to arachidonic_acid .
12031898	0	arachidonic_acid	27,43	MnSOD	13,18	arachidonic acid	MnSOD	MESH:D016718	6648	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Induction of MnSOD gene by arachidonic_acid is mediated by reactive oxygen species and p38 MAPK signaling pathway in human HepG2 hepatoma cells .
14735432	1	arachidonic_acid	63,79	NF-kappaB	130,139	arachidonic acid	NF-kappaB	MESH:D016718	4790	Chemical	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	Part I. Action on arachidonic_acid pathway , nitric_oxide and nuclear_factor_kappa_B -LRB- NF-kappaB -RRB- .
8532598	0	arachidonic_acid	24,40	Neuromedin_B	0,12	arachidonic acid	Neuromedin B	MESH:D016718	4828	Chemical	Gene	START_ENTITY|nsubj|stimulates stimulates|compound|END_ENTITY	Neuromedin_B stimulates arachidonic_acid release , c-fos gene expression , and the growth of C6_glioma cells .
16713698	0	arachidonic_acid	29,45	PCB	0,3	arachidonic acid	PCB	MESH:D016718	25104(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	PCB 50 stimulates release of arachidonic_acid and prostaglandins from late gestation rat amnion fibroblast cells .
18304389	0	arachidonic_acid	60,76	PPARalpha	15,24	arachidonic acid	PPARalpha	MESH:D016718	5465	Chemical	Gene	effect|nmod|START_ENTITY Involvement|nmod|effect Involvement|nmod|END_ENTITY	Involvement of PPARalpha in the growth inhibitory effect of arachidonic_acid on breast_cancer cells .
3138901	0	arachidonic_acid	87,103	Phospholipase_A2	0,16	arachidonic acid	Phospholipase A2	MESH:D016718	151056	Chemical	Gene	sources|nmod|START_ENTITY stimulated|nmod|sources stimulated|nsubj|END_ENTITY	Phospholipase_A2 stimulated release of lipoxin_B4 formation from endogenous sources of arachidonic_acid in porcine leukocytes .
12928414	0	arachidonic_acid	17,33	TNF	54,57	arachidonic acid	TNF	MESH:D016718	7124	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Unique effect of arachidonic_acid on human neutrophil TNF receptor expression : up-regulation involving protein kinase C , extracellular signal-regulated kinase , and phospholipase_A2 .
1899225	0	arachidonic_acid	62,78	TNF	0,3	arachidonic acid	TNF	MESH:D016718	21926(Tax:10090)	Chemical	Gene	conversion|nmod|START_ENTITY requiring|dobj|conversion pathway|acl|requiring c-fos|nmod|pathway induces|dobj|c-fos induces|nsubj|END_ENTITY	TNF induces c-fos via a novel pathway requiring conversion of arachidonic_acid to a lipoxygenase metabolite .
8580367	0	arachidonic_acid	73,89	TNF	16,19	arachidonic acid	TNF	MESH:D016718	21926(Tax:10090)	Chemical	Gene	dismutase|amod|START_ENTITY role|nmod|dismutase Augmentation|dep|role Augmentation|nmod|cytotoxicity cytotoxicity|compound|END_ENTITY	Augmentation of TNF cytotoxicity by protein_kinase_C inhibitors : role of arachidonic_acid and manganese_superoxide dismutase .
8763993	0	arachidonic_acid	201,217	TNF	127,130	arachidonic acid	TNF	MESH:D016718	21926(Tax:10090)	Chemical	Gene	release|nmod|START_ENTITY inhibit|dobj|release inhibit|nsubj|protein protein|acl:relcl|inhibit inhibit|dobj|tumor_necrosis_factor tumor_necrosis_factor|appos|END_ENTITY	The adenovirus E3-14 .7 K protein and the E3-10 .4 K/14 .5 K complex of proteins , which independently inhibit tumor_necrosis_factor -LRB- TNF -RRB- - induced apoptosis , also independently inhibit TNF-induced release of arachidonic_acid .
2162326	0	arachidonic_acid	67,83	TNF-alpha	36,45	arachidonic acid	TNF-alpha	MESH:D016718	7124	Chemical	Gene	release|amod|START_ENTITY stimulates|dobj|release stimulates|nsubj|factor-alpha factor-alpha|appos|END_ENTITY	Human tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- directly stimulates arachidonic_acid release in human neutrophils .
7747431	0	arachidonic_acid	32,48	TNF-alpha	12,21	arachidonic acid	TNF-alpha	MESH:D016718	7124	Chemical	Gene	release|amod|START_ENTITY regulates|dobj|release regulates|nsubj|END_ENTITY	HIV-induced TNF-alpha regulates arachidonic_acid and PGE2 release from HIV-infected mononuclear phagocytes .
8360590	0	arachidonic_acid	32,48	TNF-alpha	52,61	arachidonic acid	TNF-alpha	MESH:D016718	21926(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Effects of in vitro exposure to arachidonic_acid on TNF-alpha production by murine peritoneal macrophages .
8888354	0	arachidonic_acid	39,55	Tumor_necrosis_factor_alpha	0,27	arachidonic acid	Tumor necrosis factor alpha	MESH:D016718	7124	Chemical	Gene	START_ENTITY|nsubj|stimulates stimulates|compound|END_ENTITY	Tumor_necrosis_factor_alpha stimulates arachidonic_acid metabolism in human osteoblastic_osteosarcomal cells .
8920714	0	arachidonic_acid	39,55	Tumor_necrosis_factor_alpha	0,27	arachidonic acid	Tumor necrosis factor alpha	MESH:D016718	24835(Tax:10116)	Chemical	Gene	metabolisms|amod|START_ENTITY stimulates|dobj|metabolisms stimulates|nsubj|END_ENTITY	Tumor_necrosis_factor_alpha stimulates arachidonic_acid metabolisms and mucus production in rat tracheal epithelial cell cultures .
2419923	0	arachidonic_acid	31,47	alpha-fetoprotein	10,27	arachidonic acid	alpha-fetoprotein	MESH:D016718	11576(Tax:10090)	Chemical	Gene	metabolism|amod|START_ENTITY END_ENTITY|nmod|metabolism	Effect of alpha-fetoprotein on arachidonic_acid metabolism in the preadipocyte cell line OB 17 .
2438210	0	arachidonic_acid	31,47	alpha-fetoprotein	10,27	arachidonic acid	alpha-fetoprotein	MESH:D016718	174	Chemical	Gene	metabolism|amod|START_ENTITY Effect|nmod|metabolism Effect|nmod|END_ENTITY	Effect of alpha-fetoprotein on arachidonic_acid metabolism in a human T-cell line .
2443931	0	arachidonic_acid	48,64	alpha-fetoprotein	10,27	arachidonic acid	alpha-fetoprotein	MESH:D016718	11576(Tax:10090)	Chemical	Gene	metabolism|amod|START_ENTITY Effect|nmod|metabolism Effect|nmod|END_ENTITY	Effect of alpha-fetoprotein and indomethacin on arachidonic_acid metabolism in P388D1 macrophages : role of leukotrienes .
6201166	0	arachidonic_acid	59,75	alpha-fetoprotein	85,102	arachidonic acid	alpha-fetoprotein	MESH:D016718	174	Chemical	Gene	binding|nmod|START_ENTITY Interaction|nmod|binding Interaction|nmod|END_ENTITY	Interaction of retinoids and bilirubin with the binding of arachidonic_acid to human alpha-fetoprotein .
8624105	0	arachidonic_acid	12,28	amyloid_precursor_protein	53,78	arachidonic acid	amyloid precursor protein	MESH:D016718	351	Chemical	Gene	role|nmod|START_ENTITY role|nmod|secretion secretion|nmod|END_ENTITY	The role of arachidonic_acid in the secretion of the amyloid_precursor_protein -LRB- APP -RRB- .
3139397	0	arachidonic_acid	16,32	angiotensin_II	114,128	arachidonic acid	angiotensin II	MESH:D016718	24179(Tax:10116)	Chemical	Gene	liberation|amod|START_ENTITY dynamics|nmod|liberation dynamics|dep|comparison comparison|nmod|END_ENTITY	The dynamics of arachidonic_acid liberation and prolactin release : a comparison of thyrotropin-releasing_hormone , angiotensin_II , and neurotensin stimulation in perifused rat anterior pituitary cells .
6798653	0	arachidonic_acid	47,63	aryl_hydrocarbon_hydroxylase	67,95	arachidonic acid	aryl hydrocarbon hydroxylase	MESH:D016718	24296(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effects of prostaglandins_E1 , _ E2 , _ F2_alpha and arachidonic_acid on aryl_hydrocarbon_hydroxylase activity of intestinal and hepatic microsomes from male rats .
1309839	0	arachidonic_acid	104,120	bradykinin	37,47	arachidonic acid	bradykinin	MESH:D016718	3827	Chemical	Gene	release|amod|START_ENTITY accompanies|dobj|release tissue|parataxis|accompanies tissue|nmod|END_ENTITY	Human decidua is a target tissue for bradykinin and kallikrein : phosphoinositide hydrolysis accompanies arachidonic_acid release in uterine decidua cells in vitro .
1810149	0	arachidonic_acid	84,100	bradykinin	10,20	arachidonic acid	bradykinin	MESH:D016718	3827	Chemical	Gene	cascade|amod|START_ENTITY step|nmod|cascade step|nsubj|Action Action|nmod|END_ENTITY	Action of bradykinin at the cyclooxygenase step in prostanoid synthesis through the arachidonic_acid cascade .
1845801	0	arachidonic_acid	140,156	bradykinin	33,43	arachidonic acid	bradykinin	MESH:D016718	3827	Chemical	Gene	involvement|nmod|START_ENTITY operates|nmod|involvement fibroblasts|parataxis|operates fibroblasts|nsubj|stimulation stimulation|nmod|END_ENTITY	Glucose transport stimulation by bradykinin in Swiss 3T3 fibroblasts : a pertussis toxin-sensitive mechanism operates without involvement of arachidonic_acid and cyclic_AMP .
2444995	0	arachidonic_acid	50,66	bradykinin	93,103	arachidonic acid	bradykinin	MESH:D016718	3827	Chemical	Gene	distribution|nmod|START_ENTITY Interference|nmod|distribution Interference|nmod|END_ENTITY	Interference with the distribution and release of arachidonic_acid in human keratinocytes by bradykinin , histamine and phosphatidic_acid .
2902085	0	arachidonic_acid	67,83	bradykinin	38,48	arachidonic acid	bradykinin	MESH:D016718	478666(Tax:9615)	Chemical	Gene	release|amod|START_ENTITY END_ENTITY|dobj|release	Phorbol_ester and neomycin dissociate bradykinin receptor-mediated arachidonic_acid release and polyphosphoinositide hydrolysis in Madin-Darby canine kidney cells .
3061568	0	arachidonic_acid	24,40	bradykinin	63,73	arachidonic acid	bradykinin	MESH:D016718	3827	Chemical	Gene	Characterization|nmod|START_ENTITY metabolites|nsubj|Characterization metabolites|xcomp|mediating mediating|dobj|hyperalgesia hyperalgesia|compound|END_ENTITY	Characterization of the arachidonic_acid metabolites mediating bradykinin and noradrenaline hyperalgesia .
3103170	0	arachidonic_acid	91,107	bradykinin	154,164	arachidonic acid	bradykinin	MESH:D016718	280833(Tax:9913)	Chemical	Gene	START_ENTITY|nmod|D4 D4|compound|END_ENTITY	Differential effects of aspirin and dexamethasone on phospholipase_A2 and C activities and arachidonic_acid release from endothelial cells in response to bradykinin and leukotriene D4 .
3132168	0	arachidonic_acid	57,73	bradykinin	85,95	arachidonic acid	bradykinin	MESH:D016718	478666(Tax:9615)	Chemical	Gene	release|amod|START_ENTITY increases|dobj|release increases|nmod|cells cells|amod|END_ENTITY	Protein kinase C modulates phospholipase C and increases arachidonic_acid release in bradykinin stimulated MDCK cells .
12020047	0	arachidonic_acid	14,30	c-Fos	67,72	arachidonic acid	c-Fos	MESH:D016718	314322(Tax:10116)	Chemical	Gene	cascade|amod|START_ENTITY Inhibition|nmod|cascade attenuates|nsubj|Inhibition attenuates|dobj|induction induction|nmod|proteins proteins|amod|END_ENTITY	Inhibition of arachidonic_acid cascade attenuates the induction of c-Fos proteins by DOI , 5-HT2A / 2C receptor agonist , in the rat cortex .
10864209	0	arachidonic_acid	58,74	c-fos	88,93	arachidonic acid	c-fos	MESH:D016718	2353	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Prostaglandin_E2 and the protein kinase A pathway mediate arachidonic_acid induction of c-fos in human prostate_cancer cells .
1899225	0	arachidonic_acid	62,78	c-fos	12,17	arachidonic acid	c-fos	MESH:D016718	14281(Tax:10090)	Chemical	Gene	conversion|nmod|START_ENTITY requiring|dobj|conversion pathway|acl|requiring END_ENTITY|nmod|pathway	TNF induces c-fos via a novel pathway requiring conversion of arachidonic_acid to a lipoxygenase metabolite .
7961634	0	arachidonic_acid	183,199	c-fos	27,32	arachidonic acid	c-fos	MESH:D016718	14281(Tax:10090)	Chemical	Gene	stimulates|nsubj|START_ENTITY report|ccomp|stimulates report|ccomp|increases increases|dobj|mRNA mRNA|amod|END_ENTITY	Arachidonic_acid increases c-fos and Egr-1 mRNA in 3T3 fibroblasts by formation of prostaglandin_E2 and activation of protein kinase C. Studying Swiss_3T3 fibroblasts , we report that arachidonic_acid strongly stimulates mRNA levels of the growth-associated immediate early genes c-fos and Egr-1 .
8464709	0	arachidonic_acid	58,74	c-fos	26,31	arachidonic acid	c-fos	MESH:D016718	314322(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY mediated|nmod|release mediated|nsubjpass|expression expression|amod|END_ENTITY	Hydrogen_peroxide-induced c-fos expression is mediated by arachidonic_acid release : role of protein_kinase_C .
9497423	0	arachidonic_acid	17,33	cPLA2	57,62	arachidonic acid	cPLA2	MESH:D016718	5321	Chemical	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	Swelling-induced arachidonic_acid release via the 85-kDa cPLA2 in human neuroblastoma cells .
15252038	0	arachidonic_acid	58,74	calcium-independent_phospholipase_A2	18,54	arachidonic acid	calcium-independent phospholipase A2	MESH:D016718	8398	Chemical	Gene	release|amod|START_ENTITY END_ENTITY|nmod|release	Role of group VIA calcium-independent_phospholipase_A2 in arachidonic_acid release , phospholipid fatty_acid incorporation , and apoptosis in U937 cells responding to hydrogen_peroxide .
1175685	0	arachidonic_acid	70,86	catalase	43,51	arachidonic acid	catalase	MESH:D016718	100340891(Tax:9986)	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nmod|effects	Blockade by metal complexing agents and by catalase of the effects of arachidonic_acid on platelets : relevance to the study of anti-inflammatory mechanisms .
1619039	0	arachidonic_acid	8,24	corticotropin-releasing_factor	39,69	arachidonic acid	corticotropin-releasing factor	MESH:D016718	81648(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|nmod|END_ENTITY	Role of arachidonic_acid metabolism on corticotropin-releasing_factor -LRB- CRF -RRB- - release induced by interleukin-1 from superfused rat hypothalami .
1630586	0	arachidonic_acid	15,31	corticotropin-releasing_factor	77,107	arachidonic acid	corticotropin-releasing factor	MESH:D016718	1392	Chemical	Gene	cascade|amod|START_ENTITY Involvement|nmod|cascade pathways|nsubj|Involvement pathways|nmod|release release|amod|END_ENTITY	Involvement of arachidonic_acid cascade pathways in interleukin-6-stimulated corticotropin-releasing_factor release in vitro .
10501211	0	arachidonic_acid	51,67	cyclooxygenase-2	207,223	arachidonic acid	cyclooxygenase-2	MESH:D016718	5743	Chemical	Gene	metabolism|amod|START_ENTITY activation|nmod|metabolism involved|nmod|activation mechanisms|acl|involved mechanisms|dep|phosphorylation phosphorylation|nmod|END_ENTITY	Signaling mechanisms involved in the activation of arachidonic_acid metabolism in human astrocytoma cells by tumor_necrosis_factor-alpha : phosphorylation of cytosolic_phospholipase_A2 and transactivation of cyclooxygenase-2 .
1457335	0	arachidonic_acid	27,43	cytochrome_P-450	10,26	arachidonic acid	cytochrome P-450	MESH:D016718	4051	Chemical	Gene	system|amod|START_ENTITY system|amod|END_ENTITY	The renal cytochrome_P-450 arachidonic_acid system .
16234312	0	arachidonic_acid	82,98	cytochrome_P-450	28,44	arachidonic acid	cytochrome P-450	MESH:D016718	25251(Tax:10116)	Chemical	Gene	metabolites|nmod|START_ENTITY metabolites|amod|END_ENTITY	Adenosine inhibits ENaC via cytochrome_P-450 epoxygenase-dependent metabolites of arachidonic_acid .
19940786	0	arachidonic_acid	43,59	cytochrome_P-450	11,27	arachidonic acid	cytochrome P-450	MESH:D016718	25251(Tax:10116)	Chemical	Gene	metabolites|nmod|START_ENTITY metabolites|amod|END_ENTITY	Intrarenal cytochrome_P-450 metabolites of arachidonic_acid in the regulation of the nonclipped kidney function in two-kidney , one-clip Goldblatt hypertensive rats .
3099765	0	arachidonic_acid	14,30	cytochrome_P-450	45,61	arachidonic acid	cytochrome P-450	MESH:D016718	100328948(Tax:9986)	Chemical	Gene	metabolism|amod|START_ENTITY Regulation|nmod|metabolism Regulation|nmod|END_ENTITY	Regulation of arachidonic_acid metabolism by cytochrome_P-450 in rabbit kidney .
3364462	0	arachidonic_acid	66,82	cytochrome_P-450	17,33	arachidonic acid	cytochrome P-450	MESH:D016718	100328948(Tax:9986)	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|amod|END_ENTITY	Renal microsomal cytochrome_P-450 and the oxidative metabolism of arachidonic_acid .
6795631	0	arachidonic_acid	66,82	cytochrome_P-450	17,33	arachidonic acid	cytochrome P-450	MESH:D016718	25251(Tax:10116)	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|amod|END_ENTITY	Liver microsomal cytochrome_P-450 and the oxidative metabolism of arachidonic_acid .
7922394	0	arachidonic_acid	80,96	cytochrome_P-450	48,64	arachidonic acid	cytochrome P-450	MESH:D016718	4051	Chemical	Gene	metabolites|nmod|START_ENTITY metabolites|amod|END_ENTITY	Prostaglandins , thromboxanes , leukotrienes , and cytochrome_P-450 metabolites of arachidonic_acid .
11411771	0	arachidonic_acid	86,102	cytochrome_P450	55,70	arachidonic acid	cytochrome P450	MESH:D016718	25251(Tax:10116)	Chemical	Gene	metabolites|nmod|START_ENTITY metabolites|amod|END_ENTITY	Abnormal pressure-natriuresis in hypertension : role of cytochrome_P450 metabolites of arachidonic_acid .
11700990	0	arachidonic_acid	109,125	cytochrome_P450	78,93	arachidonic acid	cytochrome P450	MESH:D016718	25251(Tax:10116)	Chemical	Gene	metabolites|nmod|START_ENTITY metabolites|amod|END_ENTITY	Liquid chromatographic-electrospray ionization-mass spectrometric analysis of cytochrome_P450 metabolites of arachidonic_acid .
12468260	0	arachidonic_acid	70,86	cytochrome_P450	39,54	arachidonic acid	cytochrome P450	MESH:D016718	4051	Chemical	Gene	metabolites|nmod|START_ENTITY metabolites|amod|END_ENTITY	Characterization and identification of cytochrome_P450 metabolites of arachidonic_acid released by human peritoneal macrophages obtained from the pouch of Douglas .
21232232	0	arachidonic_acid	111,127	cytochrome_P450	80,95	arachidonic acid	cytochrome P450	MESH:D016718	4051	Chemical	Gene	metabolites|nmod|START_ENTITY metabolites|amod|END_ENTITY	Transduction of physical force by the vascular wall Role of phospholipase C and cytochrome_P450 metabolites of arachidonic_acid .
22173545	0	arachidonic_acid	104,120	cytochrome_P450	77,92	arachidonic acid	cytochrome P450	MESH:D016718	4051	Chemical	Gene	pathway|nmod|START_ENTITY pathway|amod|END_ENTITY	Hypertension , cardiovascular risk and polymorphisms in genes controlling the cytochrome_P450 pathway of arachidonic_acid : A sex-specific relation ?
26893848	0	arachidonic_acid	14,30	cytochrome_P450	38,53	arachidonic acid	cytochrome P450	MESH:D016718	4051	Chemical	Gene	START_ENTITY|nmod|enzyme enzyme|amod|END_ENTITY	Metabolism of arachidonic_acid by the cytochrome_P450 enzyme in patients with chronic Keshan_disease and dilated_cardiomyopathy .
7738183	0	arachidonic_acid	37,53	cytochrome_P450	21,36	arachidonic acid	cytochrome P450	MESH:D016718	100328948(Tax:9986)	Chemical	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	The rabbit pulmonary cytochrome_P450 arachidonic_acid metabolic pathway : characterization and significance .
8422904	0	arachidonic_acid	86,102	cytochrome_P450	55,70	arachidonic acid	cytochrome P450	MESH:D016718	25251(Tax:10116)	Chemical	Gene	metabolites|nmod|START_ENTITY metabolites|amod|END_ENTITY	Activation of K + channel in vascular smooth muscles by cytochrome_P450 metabolites of arachidonic_acid .
8847486	0	arachidonic_acid	112,128	cytochrome_P450	82,97	arachidonic acid	cytochrome P450	MESH:D016718	4051	Chemical	Gene	metabolite|nmod|START_ENTITY metabolite|amod|END_ENTITY	Regulation of calcium influx and catecholamine secretion in chromaffin cells by a cytochrome_P450 metabolite of arachidonic_acid .
20846129	0	arachidonic_acid	95,111	cytochrome_p-450	78,94	arachidonic acid	cytochrome p-450	MESH:D016718	4051	Chemical	Gene	metabolites|amod|START_ENTITY metabolites|amod|END_ENTITY	Endothelin-1 induced vascular smooth muscle cell proliferation is mediated by cytochrome_p-450 arachidonic_acid metabolites .
10501211	0	arachidonic_acid	51,67	cytosolic_phospholipase_A2	157,183	arachidonic acid	cytosolic phospholipase A2	MESH:D016718	5321	Chemical	Gene	metabolism|amod|START_ENTITY activation|nmod|metabolism involved|nmod|activation mechanisms|acl|involved mechanisms|dep|phosphorylation phosphorylation|nmod|END_ENTITY	Signaling mechanisms involved in the activation of arachidonic_acid metabolism in human astrocytoma cells by tumor_necrosis_factor-alpha : phosphorylation of cytosolic_phospholipase_A2 and transactivation of cyclooxygenase-2 .
12147293	0	arachidonic_acid	21,37	cytosolic_phospholipase_A2	49,75	arachidonic acid	cytosolic phospholipase A2	MESH:D016718	24653(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Endothelin-1-induced arachidonic_acid release by cytosolic_phospholipase_A2 activation in rat vascular smooth muscle via extracellular signal-regulated kinases pathway .
7575453	0	arachidonic_acid	38,54	cytosolic_phospholipase_A2	8,34	arachidonic acid	cytosolic phospholipase A2	MESH:D016718	24653(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY END_ENTITY|nmod|release	Role of cytosolic_phospholipase_A2 in arachidonic_acid release of rat-liver macrophages : regulation by Ca2 + and phosphorylation .
8939965	0	arachidonic_acid	165,181	cytosolic_phospholipase_A2	112,138	arachidonic acid	cytosolic phospholipase A2	MESH:D016718	100008748(Tax:9986)	Chemical	Gene	release|amod|START_ENTITY END_ENTITY|nmod|release	Calcium/calmodulin-dependent _ protein_kinase_IIalpha mediates activation of mitogen-activated protein kinase and cytosolic_phospholipase_A2 in norepinephrine-induced arachidonic_acid release in rabbit aortic smooth muscle cells .
9525925	0	arachidonic_acid	84,100	cytosolic_phospholipase_A2	43,69	arachidonic acid	cytosolic phospholipase A2	MESH:D016718	5321	Chemical	Gene	release|amod|START_ENTITY regulating|dobj|release role|acl|regulating role|nmod|END_ENTITY	The role of calcium and phosphorylation of cytosolic_phospholipase_A2 in regulating arachidonic_acid release in macrophages .
9768595	0	arachidonic_acid	88,104	cytosolic_phospholipase_A2	19,45	arachidonic acid	cytosolic phospholipase A2	MESH:D016718	5321	Chemical	Gene	generation|compound|START_ENTITY associated|nmod|generation associated|nsubjpass|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation of cytosolic_phospholipase_A2 by IL-3 is associated with increased free arachidonic_acid generation and leukotriene_C4 release in human basophils .
9973512	0	arachidonic_acid	65,81	cytosolic_phospholipase_A2	19,45	arachidonic acid	cytosolic phospholipase A2	MESH:D016718	5321	Chemical	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of cytosolic_phospholipase_A2 and the release of arachidonic_acid in human neutrophils .
9523100	0	arachidonic_acid	26,42	endothelin-1	83,95	arachidonic acid	endothelin-1	MESH:D016718	100009270(Tax:9986)	Chemical	Gene	cascade|amod|START_ENTITY reaction|nmod|cascade reaction|nmod|END_ENTITY	Inflammatory reaction via arachidonic_acid cascade after intravitreal injection of endothelin-1 .
1966520	0	arachidonic_acid	16,32	epidermal_growth_factor	72,95	arachidonic acid	epidermal growth factor	MESH:D016718	1950	Chemical	Gene	START_ENTITY|nmod|presence presence|nmod|END_ENTITY	Mobilisation of arachidonic_acid in human A431 cells in the presence of epidermal_growth_factor , calcium ions , and cyclic_AMP .
712628	0	arachidonic_acid	15,31	erythropoietin	35,49	arachidonic acid	erythropoietin	MESH:D016718	13856(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	The effects of arachidonic_acid on erythropoietin production in exhypoxic polycythemic mice and the isolated perfused canine kidney .
17492269	0	arachidonic_acid	84,100	fatty_acid_desaturase	118,139	arachidonic acid	fatty acid desaturase	MESH:D016718	6319	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Spore germination in Mortierella alpina is associated with a transient depletion of arachidonic_acid and induction of fatty_acid_desaturase gene expression .
6440783	0	arachidonic_acid	24,40	insulin	44,51	arachidonic acid	insulin	MESH:D016718	3630	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	The effect of exogenous arachidonic_acid on insulin secretion in isolated perifused hamster islets .
7947736	0	arachidonic_acid	29,45	insulin	63,70	arachidonic acid	insulin	MESH:D016718	3630	Chemical	Gene	hydrolysis|nmod|START_ENTITY necessary|nsubj|hydrolysis necessary|nmod|secretion secretion|compound|END_ENTITY	Diacylglycerol hydrolysis to arachidonic_acid is necessary for insulin secretion from isolated pancreatic islets : sequential actions of diacylglycerol and monoacylglycerol_lipases .
9012737	0	arachidonic_acid	151,167	intercellular_adhesion_molecule-1	48,81	arachidonic acid	intercellular adhesion molecule-1	MESH:D016718	3383	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of stimulus-induced endothelial cell intercellular_adhesion_molecule-1 , E-selectin , and vascular cellular adhesion molecule-1 expression by arachidonic_acid and its hydroxy and hydroperoxy derivatives .
3103171	0	arachidonic_acid	15,31	interleukin-1_alpha	90,109	arachidonic acid	interleukin-1 alpha	MESH:D016718	3552	Chemical	Gene	metabolism|amod|START_ENTITY Stimulation|nmod|metabolism Stimulation|dep|differences differences|nmod|potencies potencies|nmod|human human|amod|END_ENTITY	Stimulation of arachidonic_acid metabolism : differences in potencies of recombinant human interleukin-1_alpha and interleukin-1_beta on two cell types .
8304239	0	arachidonic_acid	60,76	interleukin-1_alpha	24,43	arachidonic acid	interleukin-1 alpha	MESH:D016718	3552	Chemical	Gene	cascade|amod|START_ENTITY effects|nmod|cascade effects|nmod|END_ENTITY	Differential effects of interleukin-1_alpha and beta on the arachidonic_acid cascade in human synovial cells and chondrocytes in culture .
8395696	0	arachidonic_acid	34,50	interleukin-1_alpha	11,30	arachidonic acid	interleukin-1 alpha	MESH:D016718	3552	Chemical	Gene	metabolism|amod|START_ENTITY END_ENTITY|nmod|metabolism	Effects of interleukin-1_alpha on arachidonic_acid metabolism in human osteosarcoma osteoblastic cells .
14643175	0	arachidonic_acid	65,81	interleukin-1alpha	13,31	arachidonic acid	interleukin-1alpha	MESH:D016718	24493(Tax:10116)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of interleukin-1alpha and COX-2 over the metabolism of arachidonic_acid and glucose in isolated uterus of restricted diet rats .
9268056	0	arachidonic_acid	44,60	interleukin-4	10,23	arachidonic acid	interleukin-4	MESH:D016718	287287(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY END_ENTITY|nmod|metabolism	Effect of interleukin-4 on allergen-induced arachidonic_acid metabolism of rat peritoneal macrophages during immediate hypersensitivity reactions .
10841042	0	arachidonic_acid	15,31	interleukin-6	59,72	arachidonic acid	interleukin-6	MESH:D016718	16193(Tax:10090)	Chemical	Gene	synthesis|amod|START_ENTITY synthesis|amod|END_ENTITY	Involvement of arachidonic_acid in chemical stress-induced interleukin-6 synthesis in osteoblast-like cells : comparison with heat_shock protein 27 induction .
11474480	0	arachidonic_acid	33,49	leptin	15,21	arachidonic acid	leptin	MESH:D016718	3952	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|Stimulation Stimulation|nmod|END_ENTITY	Stimulation of leptin release by arachidonic_acid and prostaglandin_E -LRB- 2 -RRB- in adipose tissue from obese humans .
15000451	0	arachidonic_acid	11,27	leptin	31,37	arachidonic acid	leptin	MESH:D016718	25608(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Effects of arachidonic_acid on leptin secretion and expression in primary cultured rat adipocytes .
3159224	0	arachidonic_acid	62,78	lipase	32,38	arachidonic acid	lipase	MESH:D016718	16891(Tax:10090)	Chemical	Gene	contributes|xcomp|START_ENTITY contributes|nsubj|END_ENTITY	The phospholipase C diglyceride lipase pathway contributes to arachidonic_acid release and prostaglandin_E2 formation in platelet-derived growth factor stimulated Swiss_3T3 cells .
9535028	0	arachidonic_acid	77,93	lipocortin_1	61,73	arachidonic acid	lipocortin 1	MESH:D016718	301	Chemical	Gene	release|amod|START_ENTITY END_ENTITY|nmod|release	Inhibitory effect of peptides derived from the N-terminus of lipocortin_1 on arachidonic_acid release and proliferation in the A549 cell line : identification of E-Q-E-Y-V as a crucial component .
3133889	0	arachidonic_acid	54,70	lipoxygenase	30,42	arachidonic acid	lipoxygenase	MESH:D016718	100009114(Tax:9986)	Chemical	Gene	metabolism|amod|START_ENTITY pathway|nmod|metabolism pathway|amod|END_ENTITY	-LSB- Possible significance of the lipoxygenase pathway of arachidonic_acid metabolism for the pathogenesis of constrictive reactions of lung blood vessels -RSB- .
6284737	0	arachidonic_acid	57,73	lipoxygenase	29,41	arachidonic acid	lipoxygenase	MESH:D016718	100009114(Tax:9986)	Chemical	Gene	metabolites|nmod|START_ENTITY metabolites|amod|END_ENTITY	Specificity of the effect of lipoxygenase metabolites of arachidonic_acid on calcium homeostasis in neutrophils .
6414114	0	arachidonic_acid	48,64	lipoxygenase	86,98	arachidonic acid	lipoxygenase	MESH:D016718	547836(Tax:3847)	Chemical	Gene	oxidation|amod|START_ENTITY oxidation|nmod|END_ENTITY	Styrene oxidation to styrene_oxide coupled with arachidonic_acid oxidation by soybean lipoxygenase .
7784474	0	arachidonic_acid	89,105	lipoxygenase	43,55	arachidonic acid	lipoxygenase	MESH:D016718	100009114(Tax:9986)	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|amod|END_ENTITY	Effects of fatty_acyl coenzyme A esters on lipoxygenase and cyclooxygenase metabolism of arachidonic_acid in rabbit platelets .
19933418	0	arachidonic_acid	23,39	myosin	43,49	arachidonic acid	myosin	MESH:D016718	79784	Chemical	Gene	START_ENTITY|nmod|ATPase ATPase|compound|END_ENTITY	Stimulatory effects of arachidonic_acid on myosin ATPase activity and contraction of smooth muscle via myosin motor domain .
6089937	0	arachidonic_acid	65,81	myosin	93,99	arachidonic acid	myosin	MESH:D016718	79784	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|compound|END_ENTITY	Platelet secretion defect associated with impaired liberation of arachidonic_acid and normal myosin light chain phosphorylation .
16814101	2	arachidonic_acid	518,534	p38	564,567	arachidonic acid	Src	MESH:D016718	6714	Chemical	Gene	START_ENTITY|dobj|liberation liberation|nmod|END_ENTITY	In primary proximal tubular epithelial cells exposed to hydrogen_peroxide -LRB- H2O2 -RRB- , both the selective cPLA2 inhibitors and the cPLA2 antisense oligonucleotides significantly attenuated H2O2-induced arachidonic_acid liberation and activation of p38 -LRB- SAPK -RRB- , ERK1/2 , and Akt1 .
22949356	0	arachidonic_acid	42,58	p38	27,30	arachidonic acid	p38	MESH:D016718	1432	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Simultaneous activation of p38 and JNK by arachidonic_acid stimulates the cytosolic phospholipase A2-dependent synthesis of lipid droplets in human monocytes .
24777398	0	arachidonic_acid	127,143	p38	100,103	arachidonic acid	p38	MESH:D016718	1432	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|MAPK MAPK|amod|END_ENTITY	Lymphocyte-derived microparticles induce apoptosis of airway epithelial cells through activation of p38 MAPK and production of arachidonic_acid .
9668117	0	arachidonic_acid	51,67	p38	15,18	arachidonic acid	p38	MESH:D016718	1432	Chemical	Gene	Stimulation|nmod|START_ENTITY Stimulation|nmod|phosphorylation phosphorylation|amod|END_ENTITY	Stimulation of p38 phosphorylation and activity by arachidonic_acid in HeLa cells , HL60 promyelocytic leukemic cells , and human neutrophils .
1310277	0	arachidonic_acid	33,49	parathyroid_hormone	10,29	arachidonic acid	parathyroid hormone	MESH:D016718	19226(Tax:10090)	Chemical	Gene	metabolism|amod|START_ENTITY END_ENTITY|nmod|metabolism	Effect of parathyroid_hormone on arachidonic_acid metabolism in mouse osteoblasts : permissive action of dexamethasone .
10403380	0	arachidonic_acid	64,80	phospholipase_A2	132,148	arachidonic acid	phospholipase A2	MESH:D016718	151056	Chemical	Gene	release|amod|START_ENTITY potentiate|dobj|release potentiate|nmod|cells cells|acl|overexpressing overexpressing|dobj|IIA IIA|amod|END_ENTITY	Polyunsaturated_fatty_acids potentiate interleukin-1-stimulated arachidonic_acid release by cells overexpressing type IIA secretory phospholipase_A2 .
11371929	0	arachidonic_acid	66,82	phospholipase_A2	112,128	arachidonic acid	phospholipase A2	MESH:D016718	8398	Chemical	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	Stimulation of protease activated receptors on RT4 cells mediates arachidonic_acid release via Ca2 + independent phospholipase_A2 .
15616655	0	arachidonic_acid	14,30	phospholipase_A2	52,68	arachidonic acid	phospholipase A2	MESH:D016718	151056	Chemical	Gene	metabolism|amod|START_ENTITY Modulation|nmod|metabolism Modulation|dep|focus focus|nmod|END_ENTITY	Modulation of arachidonic_acid metabolism : focus on phospholipase_A2 -LRB- S -RRB- .
17456042	0	arachidonic_acid	80,96	phospholipase_A2	49,65	arachidonic acid	phospholipase A2	MESH:D016718	151056	Chemical	Gene	pathway|amod|START_ENTITY inhibitors|nmod|pathway inhibitors|amod|END_ENTITY	Chemistry and structural evaluation of different phospholipase_A2 inhibitors in arachidonic_acid pathway mediated inflammation and snake venom_toxicity .
1851918	0	arachidonic_acid	80,96	phospholipase_A2	115,131	arachidonic acid	phospholipase A2	MESH:D016718	151056	Chemical	Gene	START_ENTITY|nmod|link link|nmod|END_ENTITY	Melittin stimulates phosphoinositide hydrolysis and placental lactogen release : arachidonic_acid as a link between phospholipase_A2 and phospholipase C signal-transduction pathways .
1872850	0	arachidonic_acid	72,88	phospholipase_A2	8,24	arachidonic acid	phospholipase A2	MESH:D016718	151056	Chemical	Gene	release|amod|START_ENTITY stimulated|dobj|release enhances|dep|stimulated enhances|nsubj|overexpression overexpression|compound|END_ENTITY	Type II phospholipase_A2 recombinant overexpression enhances stimulated arachidonic_acid release .
20041255	0	arachidonic_acid	38,54	phospholipase_A2	125,141	arachidonic acid	phospholipase A2	MESH:D016718	151056	Chemical	Gene	START_ENTITY|nmod|keratinocytes keratinocytes|nmod|END_ENTITY	Platelet activating factor stimulates arachidonic_acid release in differentiated keratinocytes via arachidonyl non-selective phospholipase_A2 .
2111085	0	arachidonic_acid	52,68	phospholipase_A2	89,105	arachidonic acid	phospholipase A2	MESH:D016718	151056	Chemical	Gene	release|nmod|START_ENTITY inhibits|dobj|release inhibits|advcl|interfering interfering|nmod|activity activity|amod|END_ENTITY	The coumarin derivative AD6 inhibits the release of arachidonic_acid by interfering with phospholipase_A2 activity in human platelets stimulated with thrombin .
2154225	0	arachidonic_acid	33,49	phospholipase_A2	113,129	arachidonic acid	phospholipase A2	MESH:D016718	151056	Chemical	Gene	metabolism|amod|START_ENTITY stimulates|dobj|metabolism stimulates|nmod|pathways pathways|acl:relcl|affected affected|nmod|inhibitors inhibitors|nmod|END_ENTITY	Human_cytomegalovirus stimulates arachidonic_acid metabolism through pathways that are affected by inhibitors of phospholipase_A2 and protein kinase C. Inhibitors of phospholipase_A2 , tetracaine and quinacrine , inhibitors of protein kinases , H-7 and H-8 , and a diacylglycerol lipase inhibitor reduced the level of CMV-induced -LSB- 3H -RSB- AA release .
25633958	0	arachidonic_acid	129,145	phospholipase_A2	112,128	arachidonic acid	phospholipase A2	MESH:D016718	151056	Chemical	Gene	insecticides|dep|START_ENTITY insecticides|acl:relcl|induce induce|xcomp|NADPH NADPH|nmod|cells cells|nmod|END_ENTITY	Organochlorine insecticides induce NADPH oxidase-dependent reactive oxygen species in human monocytic cells via phospholipase_A2 / arachidonic_acid .
3019332	0	arachidonic_acid	31,47	phospholipase_A2	57,73	arachidonic acid	phospholipase A2	MESH:D016718	151056	Chemical	Gene	NADPH-oxidase|nmod|START_ENTITY Activation|nmod|NADPH-oxidase involves|nsubj|Activation involves|dobj|END_ENTITY	Activation of NADPH-oxidase by arachidonic_acid involves phospholipase_A2 in intact human neutrophils but not in the cell-free system .
3100296	0	arachidonic_acid	15,31	phospholipase_A2	47,63	arachidonic acid	phospholipase A2	MESH:D016718	151056	Chemical	Gene	metabolism|amod|START_ENTITY Stimulation|nmod|metabolism Stimulation|nmod|END_ENTITY	Stimulation of arachidonic_acid metabolism via phospholipase_A2 by triethyl lead .
3107549	0	arachidonic_acid	85,101	phospholipase_A2	2,18	arachidonic acid	phospholipase A2	MESH:D016718	151056	Chemical	Gene	sources|nmod|START_ENTITY provokes|nmod|sources provokes|nsubj|isoenzyme isoenzyme|amod|END_ENTITY	A phospholipase_A2 isoenzyme provokes lipoxin B formation from endogenous sources of arachidonic_acid in porcine leukocytes .
3111541	0	arachidonic_acid	28,44	phospholipase_A2	77,93	arachidonic acid	phospholipase A2	MESH:D016718	151056	Chemical	Gene	START_ENTITY|nmod|action action|nmod|END_ENTITY	Evidence for the release of arachidonic_acid through the selective action of phospholipase_A2 in thrombin-stimulated human platelets .
3112131	0	arachidonic_acid	30,46	phospholipase_A2	58,74	arachidonic acid	phospholipase A2	MESH:D016718	151056	Chemical	Gene	release|amod|START_ENTITY stimulate|dobj|release stimulate|nmod|END_ENTITY	Guanine nucleotides stimulate arachidonic_acid release by phospholipase_A2 in saponin-permeabilized human platelets .
3240001	0	arachidonic_acid	54,70	phospholipase_A2	99,115	arachidonic acid	phospholipase A2	MESH:D016718	151056	Chemical	Gene	liberation|amod|START_ENTITY liberation|nmod|action action|nmod|END_ENTITY	Preterm_labor_and_bacterial_intra-amniotic_infection : arachidonic_acid liberation by the action of phospholipase_A2 .
6811781	0	arachidonic_acid	60,76	phospholipase_A2	29,45	arachidonic acid	phospholipase A2	MESH:D016718	151056	Chemical	Gene	release|nmod|START_ENTITY END_ENTITY|nmod|release	Evidence for predominance of phospholipase_A2 in release of arachidonic_acid in thrombin-activated platelets : phosphatidylinositol-specific phospholipase C may play a minor role in arachidonate liberation .
7271829	0	arachidonic_acid	15,31	phospholipase_A2	58,74	arachidonic acid	phospholipase A2	MESH:D016718	151056	Chemical	Gene	cascade|amod|START_ENTITY Studies|nmod|cascade Studies|dep|Inhibition Inhibition|nmod|END_ENTITY	Studies on the arachidonic_acid cascade -- I. Inhibition of phospholipase_A2 in vitro and in vivo by several novel series of inhibitor compounds .
7462211	1	arachidonic_acid	144,160	phospholipase_A2	97,113	arachidonic acid	phospholipase A2	MESH:D016718	151056	Chemical	Gene	liberation|nmod|START_ENTITY Support|nmod|liberation Support|nmod|pathway pathway|amod|END_ENTITY	Support for the phospholipase_A2 pathway for the liberation of arachidonic_acid .
7562496	0	arachidonic_acid	76,92	phospholipase_A2	34,50	arachidonic acid	phospholipase A2	MESH:D016718	151056	Chemical	Gene	release|amod|START_ENTITY alters|dobj|release alters|nsubj|SB_203347 SB_203347|appos|inhibitor inhibitor|nmod|END_ENTITY	SB_203347 , an inhibitor of 14 kDa phospholipase_A2 , alters human neutrophil arachidonic_acid release and metabolism and prolongs survival in murine endotoxin_shock .
7688962	0	arachidonic_acid	45,61	phospholipase_A2	28,44	arachidonic acid	phospholipase A2	MESH:D016718	151056	Chemical	Gene	C/phosphoinositol|amod|START_ENTITY pathways|nsubj|C/phosphoinositol involvement|parataxis|pathways involvement|nmod|END_ENTITY	Differential involvement of phospholipase_A2 / arachidonic_acid and phospholipase C/phosphoinositol pathways during cholecystokinin receptor activated Ca2 + oscillations in pancreatic acini .
7840783	0	arachidonic_acid	29,45	phospholipase_A2	98,114	arachidonic acid	phospholipase A2	MESH:D016718	104974671	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	N-ethyl_maleimide stimulates arachidonic_acid release through activation of the signal-responsive phospholipase_A2 in endothelial cells .
7886692	0	arachidonic_acid	118,134	phospholipase_A2	45,61	arachidonic acid	phospholipase A2	MESH:D016718	18784(Tax:10090)	Chemical	Gene	mobilization|amod|START_ENTITY linked|nmod|mobilization linked|nsubj|relatedness relatedness|nmod|END_ENTITY	Immunochemical relatedness between secretory phospholipase_A2 and intracellular phospholipase_A2 activity linked with arachidonic_acid mobilization in macrophages .
8387780	0	arachidonic_acid	13,29	phospholipase_A2	44,60	arachidonic acid	phospholipase A2	MESH:D016718	151056	Chemical	Gene	START_ENTITY|nmod|indices indices|nmod|activity activity|amod|END_ENTITY	Influence of arachidonic_acid on indices of phospholipase_A2 activity in the human neutrophil .
8446649	0	arachidonic_acid	107,123	phospholipase_A2	125,141	arachidonic acid	phospholipase A2	MESH:D016718	151056	Chemical	Gene	availability|amod|START_ENTITY availability|amod|END_ENTITY	Prostaglandin_F2_alpha synthesis in the hippocampal mossy fiber synaptosomal preparation : I. Dependence in arachidonic_acid , phospholipase_A2 , calcium availability and membrane depolarization .
8510560	0	arachidonic_acid	100,116	phospholipase_A2	61,77	arachidonic acid	phospholipase A2	MESH:D016718	104974671	Chemical	Gene	release|amod|START_ENTITY END_ENTITY|nmod|release	Involvement of a pertussis toxin-sensitive G protein-coupled phospholipase_A2 in agonist-stimulated arachidonic_acid release in membranes isolated from bovine iris sphincter smooth muscle .
8545605	0	arachidonic_acid	82,98	phospholipase_A2	10,26	arachidonic acid	phospholipase A2	MESH:D016718	151056	Chemical	Gene	cells|amod|START_ENTITY release|nmod|cells mediate|dobj|release mediate|nsubj|Cytosolic Cytosolic|amod|END_ENTITY	Cytosolic phospholipase_A2 and cyclooxygenase-2 mediate release and metabolism of arachidonic_acid in tumor_necrosis_factor-alpha-primed cultured intestinal epithelial cells -LRB- INT 407 -RRB- .
8615870	0	arachidonic_acid	75,91	phospholipase_A2	30,46	arachidonic acid	phospholipase A2	MESH:D016718	151056	Chemical	Gene	release|amod|START_ENTITY mediator|nmod|release END_ENTITY|nmod|mediator	Characterisation of cytosolic phospholipase_A2 as mediator of the enhanced arachidonic_acid release from dimethyl_sulphoxide differentiated U937 cells .
8943703	11	arachidonic_acid	1733,1749	phospholipase_A2	1794,1810	arachidonic acid	phospholipase A2	MESH:D016718	151056	Chemical	Gene	release|amod|START_ENTITY release|acl|suggesting suggesting|dobj|involvement involvement|nmod|END_ENTITY	Furthermore , dexamethasone inhibited arachidonic_acid -LRB- AA -RRB- release , suggesting the involvement of phospholipase_A2 in PGF2 alpha-induced PG release .
9593733	0	arachidonic_acid	12,28	phospholipase_A2	69,85	arachidonic acid	phospholipase A2	MESH:D016718	151056	Chemical	Gene	release|amod|START_ENTITY mediated|nsubjpass|release mediated|nmod|+ +|dep|END_ENTITY	Fas-induced arachidonic_acid release is mediated by Ca2 + - independent phospholipase_A2 but not cytosolic phospholipase_A2 , which undergoes proteolytic inactivation .
10318799	0	arachidonic_acid	84,100	phospholipase_C-gamma1	42,64	arachidonic acid	phospholipase C-gamma1	MESH:D016718	281987(Tax:9913)	Chemical	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	AHNAK , a protein that binds and activates phospholipase_C-gamma1 in the presence of arachidonic_acid .
6799774	0	arachidonic_acid	51,67	placental_lactogen	21,39	arachidonic acid	placental lactogen	MESH:D016718	1443	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|Stimulation Stimulation|nmod|END_ENTITY	Stimulation of human placental_lactogen release by arachidonic_acid .
1977095	0	arachidonic_acid	8,24	somatostatin	98,110	arachidonic acid	somatostatin	MESH:D016718	24797(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|release release|nmod|END_ENTITY	Role of arachidonic_acid or its metabolites in growth-hormone-releasing_factor-induced release of somatostatin from the median eminence .
23298476	0	arachidonic_acid	63,79	substance_P	23,34	arachidonic acid	substance P	MESH:D016718	6863	Chemical	Gene	generation|amod|START_ENTITY END_ENTITY|nmod|generation	Impact of neuropeptide substance_P an inflammatory compound on arachidonic_acid compound generation .
3116710	0	arachidonic_acid	113,129	thrombin	163,171	arachidonic acid	thrombin	MESH:D016718	2147	Chemical	Gene	START_ENTITY|nmod|platelets platelets|acl|stimulated stimulated|nmod|END_ENTITY	AD6 -LRB- 8-monochloro-3-beta-diethylamino-ethyl-4-methyl-7-ethoxycarbonyl-meth_oxy_coumarin -RRB- inhibits the release of arachidonic_acid in human platelets stimulated by thrombin .
984037	0	arachidonic_acid	59,75	thrombin	14,22	arachidonic acid	thrombin	MESH:D016718	2147	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|END_ENTITY	The effect of thrombin on the uptake and transformation of arachidonic_acid by human platelets .
18191813	0	arachidonic_acid	11,27	tumor_necrosis_factor-alpha	39,66	arachidonic acid	tumor necrosis factor-alpha	MESH:D016718	21926(Tax:10090)	Chemical	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Release of arachidonic_acid induced by tumor_necrosis_factor-alpha in the presence of caspase inhibition : evidence for a cytosolic phospholipase A2alpha-independent pathway .
8808758	0	arachidonic_acid	59,75	tumor_necrosis_factor-alpha	10,37	arachidonic acid	tumor necrosis factor-alpha	MESH:D016718	7124	Chemical	Gene	metabolism|nmod|START_ENTITY Effect|nmod|metabolism Effect|nmod|END_ENTITY	Effect of tumor_necrosis_factor-alpha on the metabolism of arachidonic_acid in human neutrophils .
9148963	0	arachidonic_acid	106,122	tumor_necrosis_factor-alpha	63,90	arachidonic acid	tumor necrosis factor-alpha	MESH:D016718	7124	Chemical	Gene	production|nmod|START_ENTITY production|nmod|END_ENTITY	Mitogen-activated protein -LRB- MAP -RRB- kinase regulates production of tumor_necrosis_factor-alpha and release of arachidonic_acid in mast cells .
15379894	0	arachidonic_acid	4,20	tumor_necrosis_factor_alpha	81,108	arachidonic acid	tumor necrosis factor alpha	MESH:D016718	21926(Tax:10090)	Chemical	Gene	nordihydroguaiaretic_acid|amod|START_ENTITY inhibits|nsubj|nordihydroguaiaretic_acid inhibits|dobj|activation activation|compound|END_ENTITY	The arachidonic_acid 5-lipoxygenase inhibitor nordihydroguaiaretic_acid inhibits tumor_necrosis_factor_alpha activation of microglia and extends survival of G93A-SOD1 transgenic_mice .
8119915	0	arachidonic_acid	18,34	tumor_necrosis_factor_alpha	92,119	arachidonic acid	tumor necrosis factor alpha	MESH:D016718	7124	Chemical	Gene	Identification|nmod|START_ENTITY hydrolysis|nsubj|Identification hydrolysis|nmod|END_ENTITY	Identification of arachidonic_acid as a mediator of sphingomyelin hydrolysis in response to tumor_necrosis_factor_alpha .
11483623	0	arachidonic_and_docosahexaenoic_acids	11,48	bile_salt-dependent_lipase	81,107	arachidonic and docosahexaenoic acids	bile salt-dependent lipase	null	1056	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of arachidonic_and_docosahexaenoic_acids on secretion and degradation of bile_salt-dependent_lipase in AR4-2J cells .
9866708	0	arachidonic_and_linoleic_acids	43,73	cytochrome_P450	12,27	arachidonic and linoleic acids	cytochrome P450	null	4051	Chemical	Gene	metabolites|nmod|START_ENTITY metabolites|amod|END_ENTITY	Analysis of cytochrome_P450 metabolites of arachidonic_and_linoleic_acids by liquid chromatography-mass spectrometry with ion trap MS. We have used reversed_phase-high_performance_liquid_chromatography-mass_spectrometry -LRB- RP-HPLC-MS -RRB- with an ion trap mass spectrometer to study the metabolism of arachidonic_and_linoleic_acids by human recombinant cytochrome_P450 -LRB- CYP -RRB- enzymes .
2115518	0	arachidonoyl	3,15	phospholipase_A2	37,53	arachidonoyl	phospholipase A2	CHEBI:22610	151056	Chemical	Gene	START_ENTITY|dep|activity activity|amod|END_ENTITY	An arachidonoyl -LRB- polyenoic -RRB- - specific phospholipase_A2 activity regulates the synthesis of platelet-activating factor in granulocytic HL-60 cells .
17986381	0	arachidonoyl_glycine	49,69	Cytochrome_c	0,12	arachidonoyl glycine	Cytochrome c	null	54205	Chemical	Gene	synthesis|nmod|START_ENTITY catalyzes|dobj|synthesis catalyzes|nsubj|END_ENTITY	Cytochrome_c catalyzes the in vitro synthesis of arachidonoyl_glycine .
1608291	0	arachidonyl-CoA	21,36	IL-1_alpha	0,10	arachidonyl-CoA	IL-1 alpha	MESH:C026563	24493(Tax:10116)	Chemical	Gene	increases|dobj|START_ENTITY increases|nsubj|END_ENTITY	IL-1_alpha increases arachidonyl-CoA : lysophospholipid acyltransferase activity and stimulates -LSB- 3H -RSB- arachidonate incorporation into phospholipids in rat mesangial cells .
14744027	5	arachidonyl_trifluoromethyl_ketone	623,657	cPLA2	685,690	arachidonyl trifluoromethyl ketone	iPLA2	MESH:C081565	360426(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	The enzyme was inhibited by arachidonyl_trifluoromethyl_ketone -LRB- AACOCF3 -RRB- , an inhibitor of cPLA2 .
17148545	0	arachidonyl_trifluoromethyl_ketone	98,132	cPLA2	143,148	arachidonyl trifluoromethyl ketone	cPLA2	MESH:C081565	24653(Tax:10116)	Chemical	Gene	points|amod|START_ENTITY points|nmod|END_ENTITY	Cytosolic PLA2 in zymogen granule fusion and amylase release : inhibition of GTP-induced fusion by arachidonyl_trifluoromethyl_ketone points to cPLA2 in G-protein-mediated secretory vesicle fusion .
18641670	0	arachidonyl_trifluoromethyl_ketone	68,102	cyclooxygenases_1_and_2	14,37	arachidonyl trifluoromethyl ketone	cyclooxygenases 1 and 2	MESH:C081565	19224;19225	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of cyclooxygenases_1_and_2 by the phospholipase-blocker , arachidonyl_trifluoromethyl_ketone .
20685770	0	arachydonilcyclopropylamide	72,99	CB1	50,53	arachydonilcyclopropylamide	CB1	null	25248(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	Anxiolytic-like effect induced by the cannabinoid CB1 receptor agonist , arachydonilcyclopropylamide -LRB- ACPA -RRB- , in the rat amygdala is mediated through the D1_and_D2 dopaminergic systems .
23488780	0	arbidol	53,60	UGT	64,67	arbidol	UGT	MESH:C086979	7361	Chemical	Gene	START_ENTITY|nmod|isoforms isoforms|compound|END_ENTITY	Glucuronidation of the broad-spectrum antiviral drug arbidol by UGT isoforms .
26383561	0	arctigenin	43,53	VEGF	16,20	arctigenin	VEGF	MESH:C071942	22339(Tax:10090)	Chemical	Gene	Suppression|nmod|START_ENTITY Suppression|nmod|expression expression|compound|END_ENTITY	-LSB- Suppression of VEGF protein expression by arctigenin in oral_squamous_cell_carcinoma -RSB- .
19429312	0	arctigenin	38,48	iNOS	104,108	arctigenin	iNOS	MESH:C071942	4843	Chemical	Gene	effects|nmod|START_ENTITY inhibition|nmod|effects inhibition|nmod|pathway pathway|amod|END_ENTITY	In vitro anti-inflammatory effects of arctigenin , a lignan from Arctium lappa L. , through inhibition on iNOS pathway .
11824521	0	ardisiaquinone_A	23,39	5-lipoxygenase	50,64	ardisiaquinone A	5-lipoxygenase	MESH:C091304	25290(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Antiallergic effect of ardisiaquinone_A , a potent 5-lipoxygenase inhibitor .
7805143	0	ardisiaquinone_A	19,35	5-lipoxygenase	46,60	ardisiaquinone A	5-lipoxygenase	MESH:C091304	240	Chemical	Gene	synthesis|nmod|START_ENTITY synthesis|appos|inhibitor inhibitor|amod|END_ENTITY	Total synthesis of ardisiaquinone_A , a potent 5-lipoxygenase inhibitor , isolated from Ardisia sieboldii , and degree of 5-lipoxygenase inhibitory activity of its derivatives .
19278990	0	arecoline	33,42	Transglutaminase-2	0,18	arecoline	Transglutaminase-2	MESH:D001115	7052	Chemical	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Transglutaminase-2 regulation by arecoline in gingival fibroblasts .
17331439	0	arecoline	12,21	hTERT	56,61	arecoline	hTERT	MESH:D001115	7015	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of arecoline and nicotine on the expression of hTERT in oral keratinocytes -RSB- .
15533212	0	arecoline	42,51	interleukin-6	14,27	arecoline	interleukin-6	MESH:D001115	3569	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of interleukin-6 expression by arecoline in human buccal mucosal fibroblasts is related to intracellular glutathione levels .
1373864	0	arecoline	72,81	nut	104,107	arecoline	nut	MESH:D001115	256646	Chemical	Gene	Study|nmod|START_ENTITY Study|nmod|END_ENTITY	Study of unscheduled DNA synthesis following exposure of human cells to arecoline and extracts of betel nut in vitro .
15539922	0	argatroban	20,30	Thrombin	0,8	argatroban	Thrombin	MESH:C031942	14061(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Thrombin inhibitor , argatroban , prevents tumor cell migration and bone metastasis .
8589208	0	argatroban	65,75	Thrombin	0,8	argatroban	Thrombin	MESH:C031942	2147	Chemical	Gene	using|dobj|START_ENTITY inhibition|advcl|using inhibition|nsubj|END_ENTITY	Thrombin inhibition in the acute phase of ischaemic_stroke using argatroban .
11085283	0	argatroban	14,24	thrombin	57,65	argatroban	thrombin	MESH:C031942	2147	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of argatroban on injured endothelial cells by thrombin .
11449671	0	argatroban	31,41	thrombin	11,19	argatroban	thrombin	MESH:C031942	2147	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	A specific thrombin inhibitor , argatroban , alleviates herpes zoster-associated pain .
11840659	0	argatroban	135,145	thrombin	156,164	argatroban	thrombin	MESH:C031942	2147	Chemical	Gene	using|dobj|START_ENTITY surgery|acl|using undergoing|dobj|surgery -LSB-|advcl|undergoing -RSB-|advcl|-LSB- -RSB-|nsubj|inhibitor inhibitor|compound|END_ENTITY	-LSB- Intraoperative management for a patient with heparin-induced_thrombocytopenia -LRB- HIT -RRB- undergoing off-pump coronary bypass surgery using argatroban , a direct thrombin inhibitor -RSB- .
1440501	0	argatroban	88,98	thrombin	112,120	argatroban	thrombin	MESH:C031942	2147	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Synergistic antithrombotic properties of G4120 , a RGD-containing synthetic peptide , and argatroban , a synthetic thrombin inhibitor , in a hamster femoral vein platelet-rich thrombosis model .
15502018	0	argatroban	15,25	thrombin	29,37	argatroban	thrombin	MESH:C031942	2147	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|generation generation|compound|END_ENTITY	The effects of argatroban on thrombin generation and hemostatic activation in vitro .
15723573	0	argatroban	44,54	thrombin	65,73	argatroban	thrombin	MESH:C031942	2147	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Alternative parenteral anticoagulation with argatroban , a direct thrombin inhibitor .
17138937	0	argatroban	117,127	thrombin	94,102	argatroban	thrombin	MESH:C031942	2147	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Platelet activity , coagulation , and fibrinolysis during exercise in healthy males : effects of thrombin inhibition by argatroban and enoxaparin .
18469550	0	argatroban	39,49	thrombin	20,28	argatroban	thrombin	MESH:C031942	2147	Chemical	Gene	START_ENTITY|nsubj|Influence Influence|nmod|inhibitor inhibitor|compound|END_ENTITY	Influence of direct thrombin inhibitor argatroban on coagulation assays in healthy individuals , patients under oral anticoagulation therapy and patients with liver_dysfunction .
19795099	0	argatroban	143,153	thrombin	124,132	argatroban	thrombin	MESH:C031942	2147	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Heparin-induced_thrombocytopenia type II with thrombosis in an intensive care patient : therapy management using the direct thrombin inhibitor argatroban -RSB- .
20216982	0	argatroban	32,42	thrombin	11,19	argatroban	thrombin	MESH:C031942	2147	Chemical	Gene	inhibitors|dep|START_ENTITY inhibitors|compound|END_ENTITY	The direct thrombin inhibitors -LRB- argatroban , bivalirudin and lepirudin -RRB- and the indirect Xa-inhibitor -LRB- danaparoid -RRB- increase fibrin network porosity and thus facilitate fibrinolysis .
21564089	0	argatroban	9,19	thrombin	91,99	argatroban	thrombin	MESH:C031942	100009146(Tax:9986)	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|dobj|contractility contractility|nmod|ligands ligands|amod|END_ENTITY	Combined argatroban and anti-oxidative agents prevents increased vascular contractility to thrombin and other ligands after subarachnoid_haemorrhage .
22359194	0	argatroban	24,34	thrombin	4,12	argatroban	thrombin	MESH:C031942	14061(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	The thrombin inhibitor , argatroban , inhibits breast_cancer metastasis to bone .
23482736	0	argatroban	26,36	thrombin	58,66	argatroban	thrombin	MESH:C031942	2147	Chemical	Gene	monitoring|nmod|START_ENTITY monitoring|acl|using using|dobj|time time|compound|END_ENTITY	Alternative monitoring of argatroban using plasma-diluted thrombin time .
26342829	10	argatroban	1396,1406	thrombin	1376,1384	argatroban	thrombin	MESH:C031942	29251(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Lower concentrations of thrombin resulted in equivalent neuroprotection as the antifibrinolytic , aprotinin , and the direct thrombin inhibitor , argatroban .
7703589	0	argatroban	36,46	thrombin	16,24	argatroban	thrombin	MESH:C031942	100009146(Tax:9986)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|dep|Use Use|nmod|END_ENTITY	Use of a direct thrombin inhibitor -LRB- argatroban -RRB- during pulse-spray thrombolysis in experimental thrombosis .
8042187	0	argatroban	88,98	thrombin	68,76	argatroban	thrombin	MESH:C031942	100009146(Tax:9986)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Inhibition of factor Xa-induced platelet_aggregation by a selective thrombin inhibitor , argatroban .
8768731	0	argatroban	33,43	thrombin	13,21	argatroban	thrombin	MESH:C031942	29251(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Effects of a thrombin inhibitor , argatroban , on ischemic brain_damage in the rat distal middle cerebral artery_occlusion model .
8797131	0	argatroban	75,85	thrombin	43,51	argatroban	thrombin	MESH:C031942	29251(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Low-molecular-weight heparin -LRB- fragmin -RRB- and thrombin active-site inhibitor -LRB- argatroban -RRB- compared in experimental arterial and venous_thrombosis and bleeding time .
9288875	0	argatroban	15,25	thrombin	34,42	argatroban	thrombin	MESH:C031942	2147	Chemical	Gene	Application|nmod|START_ENTITY Application|appos|inhibitor inhibitor|compound|END_ENTITY	Application of argatroban , direct thrombin inhibitor , in heparin-intolerant patients requiring extracorporeal circulation .
9469622	0	argatroban	19,29	thrombin	57,65	argatroban	thrombin	MESH:C031942	2147	Chemical	Gene	brand|nmod|START_ENTITY Novastan|dep|brand Novastan|dep|inhibitor inhibitor|compound|END_ENTITY	Novastan -LRB- brand of argatroban -RRB- : a small-molecule , direct thrombin inhibitor .
9469624	0	argatroban	10,20	thrombin	34,42	argatroban	thrombin	MESH:C031942	29251(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Effect of argatroban , a selective thrombin inhibitor , on animal models of cerebral_thrombosis .
9469625	0	argatroban	33,43	thrombin	14,22	argatroban	thrombin	MESH:C031942	2147	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|inhibitor inhibitor|compound|END_ENTITY	Effect of the thrombin inhibitor argatroban in acute_cerebral_thrombosis .
9731064	0	argatroban	41,51	thrombin	68,76	argatroban	thrombin	MESH:C031942	2147	Chemical	Gene	inhibition|nmod:poss|START_ENTITY effect|nmod|inhibition effect|nmod|END_ENTITY	No effect of clot age or thrombolysis on argatroban 's inhibition of thrombin .
2080419	0	arginin-vasotocin	31,48	Growth_hormone	0,14	arginin-vasotocin	Growth hormone	null	2688	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|END_ENTITY	Growth_hormone -LRB- GH -RRB- release by arginin-vasotocin -LRB- AVT -RRB- given intranasally in sexually immature children .
12428010	0	arginine	17,25	ADC2	40,44	arginine	ADC2	CHEBI:29016	829623(Tax:3702)	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Induction of the arginine decarboxylase ADC2 gene provides evidence for the involvement of polyamines in the wound response in Arabidopsis .
22693618	0	arginine	9,17	AMT1	4,8	arginine	AMT1	CHEBI:29016	853019(Tax:4932)	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	The AMT1 arginine methyltransferase gene is important for plant_infection and normal hyphal growth in Fusarium_graminearum .
21046201	0	arginine	8,16	AP-1	41,45	arginine	AP-1	CHEBI:29016	24516(Tax:10116)	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Enteral arginine modulates inhibition of AP-1 / c-Jun by SP600125 in the postischemic gut .
6989887	0	arginine	29,37	C-peptide	7,16	arginine	C-peptide	CHEBI:29016	3630	Chemical	Gene	response|xcomp|START_ENTITY response|nsubj|END_ENTITY	Plasma C-peptide response to arginine in insulin-dependent diabetic subjects .
12475743	0	arginine	38,46	CAT-1	61,66	arginine	CAT-1	CHEBI:29016	25648(Tax:10116)	Chemical	Gene	transporters|compound|START_ENTITY regulation|nmod|transporters regulation|dep|END_ENTITY	Differential regulation of glomerular arginine transporters -LRB- CAT-1 and CAT-2 -RRB- in lipopolysaccharide-treated rats .
15743275	0	arginine	138,146	CAT-1	62,67	arginine	CAT-1	CHEBI:29016	539465(Tax:9913)	Chemical	Gene	transport|amod|START_ENTITY involving|dobj|transport enhances|xcomp|involving enhances|nsubj|Interaction Interaction|nmod|endothelial_nitric_oxide_synthase endothelial_nitric_oxide_synthase|nmod|transporter transporter|compound|END_ENTITY	Interaction of the endothelial_nitric_oxide_synthase with the CAT-1 arginine transporter enhances NO release by a mechanism not involving arginine transport .
15743275	0	arginine	68,76	CAT-1	62,67	arginine	CAT-1	CHEBI:29016	539465(Tax:9913)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Interaction of the endothelial_nitric_oxide_synthase with the CAT-1 arginine transporter enhances NO release by a mechanism not involving arginine transport .
19843630	0	arginine	7,15	CAT-1	82,87	arginine	CAT-1	CHEBI:29016	25648(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY attenuated|nsubjpass|transport attenuated|nmod|modulation modulation|nmod|END_ENTITY	Aortic arginine transport is attenuated , through post-translational modulation of CAT-1 by PKCalpha , in old male rats .
16254053	10	arginine	1438,1446	CBP	1462,1465	arginine	CBP	CHEBI:29016	1387	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	Using wild-type CBP and a mutant of CBP lacking the CARM1-targeted arginine residues -LRB- R3A -RRB- , we show that arginine methylation of CBP is required for IFN-gamma induction of MHC-II .
10521420	0	arginine	39,47	Cat-1	60,65	arginine	Cat-1	CHEBI:29016	6541	Chemical	Gene	transporter|amod|START_ENTITY regulation|nmod|transporter END_ENTITY|nsubj|regulation	Post-transcriptional regulation of the arginine transporter Cat-1 by amino_acid availability .
9891757	0	arginine	42,50	Cat-1	63,68	arginine	Cat-1	CHEBI:29016	25648(Tax:10116)	Chemical	Gene	transporter|amod|START_ENTITY gene|nmod|transporter expression|nmod|gene Control|nmod|expression END_ENTITY|nsubj|Control	Control of expression of the gene for the arginine transporter Cat-1 in rat liver cells by glucocorticoids and insulin .
26940553	0	arginine	30,38	Cdt1	51,55	arginine	Cdt1	CHEBI:29016	67177(Tax:10090)	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	Characterization of conserved arginine residues on Cdt1 that affect licensing activity and interaction with Geminin or Mcm complex .
19284480	0	arginine	8,16	Cln3	71,75	arginine	Cln3	CHEBI:29016	12752(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|nmod|END_ENTITY	Altered arginine metabolism in the central nervous system -LRB- CNS -RRB- of the Cln3 - / - mouse model of juvenile Batten disease .
22532369	4	arginine	825,833	FoxO1	849,854	arginine	FoxO1	CHEBI:29016	56458(Tax:10090)	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	In this study , we attempted to directly test the effect of arginine methylation of FoxO1 on hepatic glucose metabolism .
22357953	0	arginine	56,64	G3BP2	80,85	arginine	G3BP2	CHEBI:29016	9908	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	Wnt3a-stimulated LRP6 phosphorylation is dependent upon arginine methylation of G3BP2 .
10199767	0	arginine	40,48	GH	20,22	arginine	GH	CHEBI:29016	2688	Chemical	Gene	response|nmod|START_ENTITY response|appos|END_ENTITY	The growth_hormone -LRB- GH -RRB- response to the arginine plus GH-releasing hormone test is correlated to the severity of lipid profile abnormalities in adult patients with GH_deficiency .
12217887	0	arginine	68,76	GH	42,44	arginine	GH	CHEBI:29016	2688	Chemical	Gene	affect|advcl|START_ENTITY affect|dobj|increase increase|nmod|release release|compound|END_ENTITY	IGF-I does not affect the net increase in GH release in response to arginine .
15613418	0	arginine	102,110	GH	59,61	arginine	GH	CHEBI:29016	2688	Chemical	Gene	mass|nmod|START_ENTITY mass|nmod|responses responses|appos|END_ENTITY	Influence of body mass index and gender on growth_hormone -LRB- GH -RRB- responses to GH-releasing hormone plus arginine and insulin tolerance tests .
1671785	0	arginine	67,75	GH	105,107	arginine	GH	CHEBI:29016	2688	Chemical	Gene	secretion|amod|START_ENTITY secretion|compound|END_ENTITY	Effects of dexamethasone on growth_hormone -LRB- GH -RRB- - releasing hormone , arginine - and dopaminergic stimulated GH secretion , and total plasma insulin-like growth factor-I concentrations in normal male volunteers .
16723138	0	arginine	31,39	GH	48,50	arginine	GH	CHEBI:29016	81668(Tax:10116)	Chemical	Gene	administration|nmod|START_ENTITY induces|nsubj|administration induces|dobj|expression expression|amod|END_ENTITY	Chronic oral administration of arginine induces GH gene expression and insulin resistance .
18341090	0	arginine	18,26	GH	93,95	arginine	GH	CHEBI:29016	2688	Chemical	Gene	plus|amod|START_ENTITY Administration|nmod|plus growth_hormone_releasing_hormone|nsubj|Administration growth_hormone_releasing_hormone|xcomp|evaluate evaluate|dobj|status status|amod|growth_hormone growth_hormone|dep|END_ENTITY	Administration of arginine plus growth_hormone_releasing_hormone to evaluate growth_hormone -LRB- GH -RRB- secretory status in children with GH_deficiency .
2229304	0	arginine	65,73	GH	16,18	arginine	GH	CHEBI:29016	2688	Chemical	Gene	administration|nmod|START_ENTITY responsiveness|nmod|administration responsiveness|nsubj|Growth_hormone Growth_hormone|appos|END_ENTITY	Growth_hormone -LRB- GH -RRB- responsiveness to combined administration of arginine and GH-releasing_hormone does not vary with age in man .
2421134	4	arginine	650,658	GH	621,623	arginine	GH	CHEBI:29016	2688	Chemical	Gene	responses|nmod|START_ENTITY depressed|nsubjpass|responses depressed|nmod|growth_hormone growth_hormone|appos|END_ENTITY	In all 3 patients growth_hormone -LRB- GH -RRB- responses to intravenous arginine were depressed and in 2 of the 3 patients , a GH-dependent 150 K serum protein carrier of IGF was absent .
26059749	0	arginine	121,129	GH	56,58	arginine	GH	CHEBI:29016	2688	Chemical	Gene	administration|compound|START_ENTITY isoforms|nmod|administration isoforms|nsubj|END_ENTITY	Unaltered ratio of circulating levels of growth_hormone / GH isoforms in adults with Prader-Willi_syndrome after GHRH plus arginine administration .
3145820	0	arginine	33,41	GH	16,18	arginine	GH	CHEBI:29016	2688	Chemical	Gene	Growth_hormone|nmod|START_ENTITY Growth_hormone|dobj|responses responses|appos|END_ENTITY	Growth_hormone -LRB- GH -RRB- responses to arginine and L-dopa alone and after GHRH pretreatment .
9589665	0	arginine	92,100	GH	68,70	arginine	GH	CHEBI:29016	2688	Chemical	Gene	Comparison|dep|START_ENTITY Comparison|appos|END_ENTITY	Comparison between insulin-induced hypoglycemia and growth_hormone -LRB- GH -RRB- - releasing hormone + arginine as provocative tests for the diagnosis of GH_deficiency in adults .
12739737	0	arginine	27,35	GHRH	17,21	arginine	GHRH	CHEBI:29016	2691	Chemical	Gene	administration|compound|START_ENTITY administration|compound|END_ENTITY	GH release after GHRH plus arginine administration in obese and overweight women with polycystic_ovary_syndrome .
26059749	0	arginine	121,129	GHRH	111,115	arginine	GHRH	CHEBI:29016	2691	Chemical	Gene	administration|compound|START_ENTITY administration|compound|END_ENTITY	Unaltered ratio of circulating levels of growth_hormone / GH isoforms in adults with Prader-Willi_syndrome after GHRH plus arginine administration .
9585379	0	arginine	29,37	GHRH	23,27	arginine	GHRH	CHEBI:29016	2691	Chemical	Gene	sequential|amod|START_ENTITY sequential|amod|END_ENTITY	Plasma GH responses to GHRH , arginine , L-dopa , pyridostigmine , sequential administrations of GHRH and combined administration of PD and GHRH in Turner 's _ syndrome .
9585379	0	arginine	29,37	GHRH	93,97	arginine	GHRH	CHEBI:29016	2691	Chemical	Gene	sequential|amod|START_ENTITY administrations|amod|sequential administrations|nmod|END_ENTITY	Plasma GH responses to GHRH , arginine , L-dopa , pyridostigmine , sequential administrations of GHRH and combined administration of PD and GHRH in Turner 's _ syndrome .
8750914	0	arginine	26,34	GLUT4	71,76	arginine	GLUT4	CHEBI:29016	6517	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	Mutation of two conserved arginine residues in the glucose transporter GLUT4 supresses transport activity , but not glucose-inhibitable binding of inhibitory ligands .
15807873	0	arginine	27,35	Growth_hormone	0,14	arginine	Growth hormone	CHEBI:29016	2688	Chemical	Gene	test|amod|START_ENTITY response|nmod|test response|amod|END_ENTITY	Growth_hormone response to arginine test distinguishes multiple system atrophy from Parkinson 's _ disease and idiopathic_late-onset cerebellar_ataxia .
15809017	0	arginine	50,58	Growth_hormone	0,14	arginine	Growth hormone	CHEBI:29016	2688	Chemical	Gene	doses|nmod|START_ENTITY END_ENTITY|nmod|doses	Growth_hormone responses to varying doses of oral arginine .
2229304	0	arginine	65,73	Growth_hormone	0,14	arginine	Growth hormone	CHEBI:29016	2688	Chemical	Gene	administration|nmod|START_ENTITY responsiveness|nmod|administration responsiveness|nsubj|END_ENTITY	Growth_hormone -LRB- GH -RRB- responsiveness to combined administration of arginine and GH-releasing_hormone does not vary with age in man .
2792459	0	arginine	28,36	Growth_hormone	1,15	arginine	Growth hormone	CHEBI:29016	2688	Chemical	Gene	response|xcomp|START_ENTITY response|nsubj|END_ENTITY	-LSB- Growth_hormone response to arginine administration in diabetics -- with special reference to the multiple regression analysis in association with diabetic_retinopathy -RSB- .
6356742	0	arginine	48,56	Growth_hormone	0,14	arginine	Growth hormone	CHEBI:29016	2688	Chemical	Gene	START_ENTITY|nsubj|following following|compound|END_ENTITY	Growth_hormone , prolactin and insulin following arginine infusion in primary_hyperparathyroidism before and after parathyroidectomy .
11779864	0	arginine	89,97	Hmt1p	114,119	arginine	Hmt1p	CHEBI:29016	852322(Tax:4932)	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	Nab2p is required for poly -LRB- A -RRB- RNA export in Saccharomyces_cerevisiae and is regulated by arginine methylation via Hmt1p .
26460953	0	arginine	47,55	INCENP	71,77	arginine	INCENP	CHEBI:29016	3619	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	PRMT1 promotes mitosis of cancer cells through arginine methylation of INCENP .
3047161	0	arginine	44,52	Insulin	0,7	arginine	Insulin	CHEBI:29016	3630	Chemical	Gene	responses|nmod|START_ENTITY responses|compound|END_ENTITY	Insulin and glucagon secretory responses to arginine , glucagon , and theophylline during perifusion of human fetal islet-like_cell_clusters .
605445	0	arginine	81,89	Insulin	0,7	arginine	Insulin	CHEBI:29016	3630	Chemical	Gene	responders|amod|START_ENTITY administration|nmod|responders stimulated|nmod|administration stimulated|nsubj|secretion secretion|amod|END_ENTITY	Insulin and growth_hormone secretion stimulated by intravenous administration of arginine in the low insulin responders -LRB- prediabetes ? -RRB- .
842341	0	arginine	33,41	Insulin	0,7	arginine	Insulin	CHEBI:29016	3630	Chemical	Gene	infusion|amod|START_ENTITY response|nmod|infusion response|compound|END_ENTITY	Insulin and glucagon response to arginine infusion in cystic fibrosis .
10346979	0	arginine	28,36	Interleukin_1beta	0,17	arginine	Interleukin 1beta	CHEBI:29016	24494(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|increases increases|amod|END_ENTITY	Interleukin_1beta increases arginine accumulation and activates the citrulline-NO cycle in rat pancreatic beta cells .
23164225	0	arginine	75,83	Milk	0,4	arginine	Milk	CHEBI:29016	100532204	Chemical	Gene	responses|acl|START_ENTITY responses|compound|END_ENTITY	Milk protein responses in dairy cows to changes in postruminal supplies of arginine , isoleucine , and valine .
18801197	9	arginine	1645,1653	NAGS	1664,1668	arginine	NAGS	CHEBI:29016	162417	Chemical	Gene	effect|amod|START_ENTITY effect|nmod|END_ENTITY	To examine at what point in evolution inversion of arginine effect on NAGS occur , we cloned NAGS from fish and frogs and examined the arginine response of their corresponding proteins .
10896665	0	arginine	81,89	Npl3p	105,110	arginine	Npl3p	CHEBI:29016	852042(Tax:4932)	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	Novel RING finger proteins , Air1p and Air2p , interact with Hmt1p and inhibit the arginine methylation of Npl3p .
18268501	0	arginine	88,96	P2RX7	104,109	arginine	P2RX7	CHEBI:29016	5027	Chemical	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	Case-control studies show that a non-conservative amino-acid change from a glutamine to arginine in the P2RX7 purinergic receptor protein is associated with both bipolar - and unipolar-affective_disorders .
15345777	0	arginine	29,37	PAD4	6,10	arginine	PAD4	CHEBI:29016	23569	Chemical	Gene	levels|amod|START_ENTITY regulates|dobj|levels regulates|nsubj|END_ENTITY	Human PAD4 regulates histone arginine methylation levels via demethylimination .
16257923	0	arginine	78,86	PPAR-gamma	26,36	arginine	PPAR-gamma	CHEBI:29016	25664(Tax:10116)	Chemical	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	Differential induction of PPAR-gamma by luminal glutamine and iNOS by luminal arginine in the rodent postischemic small bowel .
21063737	0	arginine	38,46	PPARa	11,16	arginine	PPARa	CHEBI:29016	19013(Tax:10090)	Chemical	Gene	metabolism|amod|START_ENTITY regulation|nmod|metabolism role|nmod|regulation role|nmod|END_ENTITY	A role for PPARa in the regulation of arginine metabolism and nitric_oxide synthesis .
23376614	0	arginine	85,93	PPIase	0,6	arginine	PPIase	CHEBI:29016	51645	Chemical	Gene	kinase|amod|START_ENTITY END_ENTITY|nmod|kinase	PPIase independent chaperone-like function of recombinant human Cyclophilin_A during arginine kinase refolding .
12101096	0	arginine	52,60	PRMT5	79,84	arginine	PRMT5	CHEBI:29016	10419	Chemical	Gene	type|amod|START_ENTITY transcription|nmod|type regulation|nmod|transcription methyltransferase|nsubj|regulation methyltransferase|dobj|END_ENTITY	Negative regulation of transcription by the type II arginine methyltransferase PRMT5 .
15485929	0	arginine	53,61	PRMT5	25,30	arginine	PRMT5	CHEBI:29016	10419	Chemical	Gene	H3|amod|START_ENTITY methylates|dobj|H3 methylates|nsubj|END_ENTITY	Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes .
18369183	5	arginine	624,632	PRMT5	653,658	arginine	Dart5	CHEBI:29016	36809(Tax:7227)	Chemical	Gene	methyltransferases|compound|START_ENTITY methyltransferases|appos|END_ENTITY	In human cells , two distinct protein arginine methyltransferases -LRB- PRMT5 and PRMT7 -RRB- are required for snRNP biogenesis .
19086919	0	arginine	60,68	PRMT5	84,89	arginine	PRMT5	CHEBI:29016	10419	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	Fibroblast_growth_factor_2 -LRB- FGF-2 -RRB- is a novel substrate for arginine methylation by PRMT5 .
23048031	0	arginine	131,139	PRMT5	105,110	arginine	PRMT5	CHEBI:29016	10419	Chemical	Gene	methylation|compound|START_ENTITY mediate|dobj|methylation recruits|xcomp|mediate recruits|dobj|protein_arginine_methyltransferase_5 protein_arginine_methyltransferase_5|appos|END_ENTITY	Transcription factor positive_regulatory_domain_4 -LRB- PRDM4 -RRB- recruits protein_arginine_methyltransferase_5 -LRB- PRMT5 -RRB- to mediate histone arginine methylation and control neural stem cell proliferation and differentiation .
25662273	0	arginine	10,18	PRMT5	4,9	arginine	PRMT5	CHEBI:29016	10419	Chemical	Gene	methyltransferase|compound|START_ENTITY methyltransferase|compound|END_ENTITY	The PRMT5 arginine methyltransferase : many roles in development , cancer and beyond .
25927346	0	arginine	26,34	PRMT5	0,5	arginine	PRMT5	CHEBI:29016	10419	Chemical	Gene	dimethylation|compound|START_ENTITY attenuated|nsubjpass|dimethylation END_ENTITY|parataxis|attenuated	PRMT5 - mediated symmetric arginine dimethylation is attenuated by mutant huntingtin and is impaired in Huntington 's _ Disease -LRB- HD -RRB- .
26086249	0	arginine	12,20	PRMT5	39,44	arginine	PRMT5	CHEBI:29016	10419	Chemical	Gene	methyltransferase|nsubj|START_ENTITY methyltransferase|ccomp|regulates regulates|nsubj|END_ENTITY	The protein arginine methyltransferase PRMT5 regulates Ab-induced toxicity in human cells and Caenorhabditis_elegans models of Alzheimer 's disease .
26536822	0	arginine	104,112	PRMT5	28,33	arginine	PRMT5	CHEBI:29016	10419	Chemical	Gene	methylation|compound|START_ENTITY activation|nmod|methylation role|dep|activation role|nmod|END_ENTITY	The dual epigenetic role of PRMT5 in acute_myeloid_leukemia : gene activation and repression via histone arginine methylation .
26554819	0	arginine	12,20	PRMT5	39,44	arginine	PRMT5	CHEBI:29016	10419	Chemical	Gene	methyltransferase|nsubj|START_ENTITY methyltransferase|ccomp|promotes promotes|nsubj|END_ENTITY	The protein arginine methyltransferase PRMT5 promotes D2-like dopamine receptor signaling .
26912360	0	arginine	55,63	PRMT5	49,54	arginine	PRMT5	CHEBI:29016	10419	Chemical	Gene	methyltransferase|compound|START_ENTITY methyltransferase|compound|END_ENTITY	MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells .
19858291	0	arginine	53,61	Prmt1	10,15	arginine	Prmt1	CHEBI:29016	3276	Chemical	Gene	target|nmod|START_ENTITY END_ENTITY|appos|target	Friend of Prmt1 , a novel chromatin target of protein arginine methyltransferases .
16699504	0	arginine	49,57	Prmt5	23,28	arginine	Prmt5	CHEBI:29016	27374(Tax:10090)	Chemical	Gene	methylation|amod|START_ENTITY histone|dobj|methylation histone|nsubj|associates associates|nmod|END_ENTITY	Blimp1 associates with Prmt5 and directs histone arginine methylation in mouse germ cells .
17043109	0	arginine	12,20	Prmt5	39,44	arginine	Prmt5	CHEBI:29016	10419	Chemical	Gene	START_ENTITY|ccomp|required required|nsubjpass|END_ENTITY	The protein arginine methyltransferase Prmt5 is required for myogenesis because it facilitates ATP-dependent chromatin remodeling .
1249182	0	arginine	22,30	Prolactin	0,9	arginine	Prolactin	CHEBI:29016	5617	Chemical	Gene	START_ENTITY|nsubj|response response|compound|END_ENTITY	Prolactin response to arginine in normal subjects and in patients with hyperthyroidism .
7151830	0	arginine	22,30	Prolactin	0,9	arginine	Prolactin	CHEBI:29016	5617	Chemical	Gene	START_ENTITY|nsubj|response response|compound|END_ENTITY	Prolactin response to arginine in children with hyperthyroidism and primary_hypothyroidism .
26010396	3	arginine	599,607	RUNX1	620,625	arginine	RUNX1	CHEBI:29016	12394(Tax:10090)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Recent studies revealed that protein_arginine_methyltransferase_1 -LRB- PRMT1 -RRB- , which accounts for the majority of the type I PRMT activity in cells , methylates two arginine residues in RUNX1 -LRB- R206 and R210 -RRB- , and these modifications inhibit corepressor-binding to RUNX1 thereby enhancing its transcriptional activity .
26010396	3	arginine	599,607	RUNX1	620,625	arginine	RUNX1	CHEBI:29016	12394(Tax:10090)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Recent studies revealed that protein_arginine_methyltransferase_1 -LRB- PRMT1 -RRB- , which accounts for the majority of the type I PRMT activity in cells , methylates two arginine residues in RUNX1 -LRB- R206 and R210 -RRB- , and these modifications inhibit corepressor-binding to RUNX1 thereby enhancing its transcriptional activity .
24627544	1	arginine	117,125	SLC7A1	138,144	arginine	SLC7A1	CHEBI:29016	6541	Chemical	Gene	mRNA|amod|START_ENTITY mRNA|compound|END_ENTITY	I. Consequences of loss of function of arginine transporter SLC7A1 mRNA in ovine conceptus trophectoderm .
2869632	0	arginine	41,49	Somatostatin	0,12	arginine	Somatostatin	CHEBI:29016	6750	Chemical	Gene	stimulation|amod|START_ENTITY END_ENTITY|nmod|stimulation	Somatostatin , insulin and glucagon after arginine stimulation in active and treated acromegaly .
6103853	0	arginine	39,47	Somatostatin	0,12	arginine	Somatostatin	CHEBI:29016	24797(Tax:10116)	Chemical	Gene	responds|xcomp|START_ENTITY responds|nsubj|concentration concentration|compound|END_ENTITY	Somatostatin concentration responds to arginine in portal plasma : effects of fasting , streptozotocin diabetes , and insulin administration in diabetic rats .
19074424	0	arginine	22,30	TAFI	54,58	arginine	TAFI	CHEBI:29016	1361	Chemical	Gene	roles|nmod|START_ENTITY roles|nmod|END_ENTITY	The roles of selected arginine and lysine residues of TAFI -LRB- Pro-CPU -RRB- in its activation to TAFIa by the thrombin-thrombomodulin complex .
15238257	0	arginine	19,27	TNFalpha	41,49	arginine	TNFalpha	CHEBI:29016	7124	Chemical	Gene	transport|amod|START_ENTITY transport|nmod|END_ENTITY	The stimulation of arginine transport by TNFalpha in human endothelial cells depends on NF-kappaB activation .
8568566	0	arginine	51,59	Thrombin	0,8	arginine	Thrombin	CHEBI:29016	2147	Chemical	Gene	derivatives|nmod|START_ENTITY inhibitors|advcl|derivatives inhibitors|nsubj|END_ENTITY	Thrombin inhibitors based on ketone derivatives of arginine and lysine .
12414939	0	arginine	55,63	Us11	92,96	arginine	Us11	CHEBI:29016	2703439(Tax:10298)	Chemical	Gene	region|amod|START_ENTITY region|nmod|END_ENTITY	Characterization of RNA determinants recognized by the arginine - and proline-rich region of Us11 , a herpes_simplex_virus_type_1-encoded double-stranded RNA binding protein that prevents PKR activation .
21747049	0	arginine	56,64	V1A	77,80	arginine	V1A	CHEBI:29016	54140(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Controlled and cardiac-restricted overexpression of the arginine vasopressin V1A receptor causes reversible left_ventricular_dysfunction through Gaq-mediated cell signaling .
8356909	0	arginine	28,36	aldose_reductase	48,64	arginine	aldose reductase	CHEBI:29016	396816(Tax:9823)	Chemical	Gene	residue|amod|START_ENTITY residue|nmod|END_ENTITY	Chemical modification of an arginine residue in aldose_reductase is enhanced by coenzyme binding : further evidence for conformational change during the reaction mechanism .
24178685	0	arginine	23,31	angiotensin_II	72,86	arginine	angiotensin II	CHEBI:29016	183	Chemical	Gene	transport|amod|START_ENTITY transport|nmod|END_ENTITY	Parallel regulation of arginine transport and nitric_oxide synthesis by angiotensin_II in vascular smooth muscle cells role of protein_kinase_C .
11160363	0	arginine	6,14	apolipoprotein_A-I	27,45	arginine	apolipoprotein A-I	CHEBI:29016	335	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Three arginine residues in apolipoprotein_A-I are critical for activation of lecithin : cholesterol_acyltransferase .
6794630	0	arginine	87,95	apolipoprotein_B	119,135	arginine	apolipoprotein B	CHEBI:29016	338	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Reduced immunoregulatory potency of low density lipoproteins with selectively modified arginine and lysine residues of apolipoprotein_B .
17708746	0	arginine	50,58	arginase-1	16,26	arginine	arginase-1	CHEBI:29016	383	Chemical	Gene	affect|dobj|START_ENTITY affect|nsubj|END_ENTITY	Elevated plasma arginase-1 does not affect plasma arginine in patients undergoing liver resection .
7493935	0	arginine	33,41	choline_acetyltransferase	49,74	arginine	choline acetyltransferase	CHEBI:29016	290567(Tax:10116)	Chemical	Gene	Identification|nmod|START_ENTITY END_ENTITY|nsubj|Identification	Identification of an active site arginine in rat choline_acetyltransferase by alanine scanning mutagenesis .
17242372	0	arginine	41,49	coproporphyrinogen_oxidase	90,116	arginine	coproporphyrinogen oxidase	CHEBI:29016	1371	Chemical	Gene	START_ENTITY|nmod|mechanism mechanism|nmod|END_ENTITY	Role of aspartate 400 , arginine_262 , and arginine 401 in the catalytic mechanism of human coproporphyrinogen_oxidase .
1751615	0	arginine	15,23	cytochrome_P-450	27,43	arginine	cytochrome P-450	CHEBI:29016	25251(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	-LSB- The effect of arginine on cytochrome_P-450 activity and the structural state of the microsomal membranes of the rat liver and testes -RSB- .
1750211	0	arginine	18,26	cytochrome_p-450	30,46	arginine	cytochrome p-450	CHEBI:29016	25251(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	-LSB- Regulation of by arginine of cytochrome_p-450 activity and lipid peroxidation in rat liver and testicular tissue during hypoxia -RSB- .
16185069	0	arginine	8,16	dihydrodipicolinate_synthase	73,101	arginine	dihydrodipicolinate synthase	CHEBI:29016	8319276(Tax:562)	Chemical	Gene	Role|nmod|START_ENTITY END_ENTITY|nsubj|Role	Role of arginine 138 in the catalysis and regulation of Escherichia_coli dihydrodipicolinate_synthase .
26078354	0	arginine	95,103	eIF4E	119,124	arginine	eIF4E	CHEBI:29016	1977	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	Targeting protein arginine methyltransferase 5 inhibits colorectal_cancer growth by decreasing arginine methylation of eIF4E and FGFR3 .
15743275	0	arginine	68,76	endothelial_nitric_oxide_synthase	19,52	arginine	endothelial nitric oxide synthase	CHEBI:29016	287024(Tax:9913)	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|nmod|transporter	Interaction of the endothelial_nitric_oxide_synthase with the CAT-1 arginine transporter enhances NO release by a mechanism not involving arginine transport .
7117668	0	arginine	103,111	fibrinogen	124,134	arginine	fibrinogen	CHEBI:29016	2244	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Inhibition of thrombin cleavage of fibrinogen by polyestradiol_phosphate ; interaction with the crucial arginine residues in fibrinogen required for enzymic cleavage .
7998345	0	arginine	36,44	fibrinogen	57,67	arginine	fibrinogen	CHEBI:29016	2244	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	-LSB- Effect of chemical modification of arginine residues of fibrinogen and its DH-fragment on the rate of hydrolysis of these proteins by plasminogen -RSB- .
290269	0	arginine	74,82	gastrin	88,95	arginine	gastrin	CHEBI:29016	445524(Tax:9823)	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	Transhepatic_hormone levels in the portacaval shunted pig -- the effects of arginine upon gastrin and glucagon release .
7055581	0	arginine	10,18	glutathione_reductase	72,93	arginine	glutathione reductase	CHEBI:29016	2936	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	Essential arginine residues in the pyridine_nucleotide binding sites of glutathione_reductase .
9576954	0	arginine	56,64	gp120	87,92	arginine	gp120	CHEBI:29016	3700	Chemical	Gene	residue|compound|START_ENTITY residue|nmod|END_ENTITY	CCR5 coreceptor utilization involves a highly conserved arginine residue of HIV_type_1 gp120 .
10199767	0	arginine	40,48	growth_hormone	4,18	arginine	growth hormone	CHEBI:29016	2688	Chemical	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	The growth_hormone -LRB- GH -RRB- response to the arginine plus GH-releasing hormone test is correlated to the severity of lipid profile abnormalities in adult patients with GH_deficiency .
1153917	0	arginine	91,99	growth_hormone	42,56	arginine	growth hormone	CHEBI:29016	2688	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|effect effect|nmod|somatostatin somatostatin|nmod|rise rise|nmod|secretion secretion|compound|END_ENTITY	The effect of somatostatin on the rise of growth_hormone and glucagon secretion induced by arginine and L-dopa in diabetic patients .
11572322	0	arginine	47,55	growth_hormone	109,123	arginine	growth hormone	CHEBI:29016	2688	Chemical	Gene	secretagogues|amod|START_ENTITY secretagogues|nmod|diagnosis diagnosis|nmod|deficiency deficiency|amod|END_ENTITY	Growth_hormone-releasing_hormone combined with arginine or growth_hormone secretagogues for the diagnosis of growth_hormone deficiency in adults .
1183914	0	arginine	74,82	growth_hormone	47,61	arginine	growth hormone	CHEBI:29016	2688	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	The influence of plasma triglycerides on human growth_hormone response to arginine and insulin : a study in hyperlipemics and normal subjects .
1261961	0	arginine	92,100	growth_hormone	65,79	arginine	growth hormone	CHEBI:29016	2688	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Effect of metergoline , a specific serotonin antagonist , on human growth_hormone response to arginine and L-dopa .
12864804	0	arginine	21,29	growth_hormone	89,103	arginine	growth hormone	CHEBI:29016	2688	Chemical	Gene	GHRH|amod|START_ENTITY effectiveness|nmod|GHRH test|nsubj|effectiveness test|advcl|test test|acl|diagnosing diagnosing|dobj|deficiency deficiency|amod|END_ENTITY	The effectiveness of arginine + GHRH test compared with GHRH + GHRP-6 test in diagnosing growth_hormone deficiency in adults .
15613418	0	arginine	102,110	growth_hormone	43,57	arginine	growth hormone	CHEBI:29016	2688	Chemical	Gene	mass|nmod|START_ENTITY mass|nmod|responses responses|amod|END_ENTITY	Influence of body mass index and gender on growth_hormone -LRB- GH -RRB- responses to GH-releasing hormone plus arginine and insulin tolerance tests .
16741262	0	arginine	5,13	growth_hormone	29,43	arginine	growth hormone	CHEBI:29016	2688	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|response response|amod|END_ENTITY	Oral arginine attenuates the growth_hormone response to resistance exercise .
16958123	0	arginine	84,92	growth_hormone	93,107	arginine	growth hormone	CHEBI:29016	2688	Chemical	Gene	test|amod|START_ENTITY test|amod|END_ENTITY	Multiple_system_atrophy is distinguished from idiopathic_Parkinson 's _ disease by the arginine growth_hormone stimulation test .
1697660	0	arginine	43,51	growth_hormone	73,87	arginine	growth hormone	CHEBI:29016	2688	Chemical	Gene	secretion|amod|START_ENTITY secretion|compound|END_ENTITY	Pyridostigmine potentiates L-dopa - but not arginine - and galanin-induced growth_hormone secretion in children .
18044703	0	arginine	4,12	growth_hormone	13,27	arginine	growth hormone	CHEBI:29016	2688	Chemical	Gene	stimulation|amod|START_ENTITY stimulation|compound|END_ENTITY	The arginine growth_hormone stimulation test in bradykinetic-rigid_parkinsonisms .
18341090	0	arginine	18,26	growth_hormone	77,91	arginine	growth hormone	CHEBI:29016	2688	Chemical	Gene	plus|amod|START_ENTITY Administration|nmod|plus growth_hormone_releasing_hormone|nsubj|Administration growth_hormone_releasing_hormone|xcomp|evaluate evaluate|dobj|status status|amod|END_ENTITY	Administration of arginine plus growth_hormone_releasing_hormone to evaluate growth_hormone -LRB- GH -RRB- secretory status in children with GH_deficiency .
19013291	0	arginine	39,47	growth_hormone	11,25	arginine	growth hormone	CHEBI:29016	2688	Chemical	Gene	ratio|amod|START_ENTITY treatment|nmod|ratio treatment|amod|END_ENTITY	Effects of growth_hormone treatment on arginine to asymmetric dimethylarginine ratio and endothelial function in patients with growth_hormone deficiency .
19013291	0	arginine	39,47	growth_hormone	127,141	arginine	growth hormone	CHEBI:29016	2688	Chemical	Gene	ratio|amod|START_ENTITY treatment|nmod|ratio Effects|nmod|treatment function|nsubj|Effects function|nmod|patients patients|nmod|deficiency deficiency|amod|END_ENTITY	Effects of growth_hormone treatment on arginine to asymmetric dimethylarginine ratio and endothelial function in patients with growth_hormone deficiency .
19106217	0	arginine	147,155	growth_hormone	18,32	arginine	growth hormone	CHEBI:29016	81668(Tax:10116)	Chemical	Gene	treated|nmod|START_ENTITY role|acl|treated role|nmod|END_ENTITY	Potential role of growth_hormone in impairment of insulin signaling in skeletal muscle , adipose tissue , and liver of rats chronically treated with arginine .
19729944	0	arginine	52,60	growth_hormone	13,27	arginine	growth hormone	CHEBI:29016	2688	Chemical	Gene	test|amod|START_ENTITY using|dobj|test deficiency|acl|using deficiency|amod|END_ENTITY	Diagnosis of growth_hormone deficiency by using the arginine provocative test : is it possible to shorten testing time without altering validity ?
1988776	0	arginine	73,81	growth_hormone	10,24	arginine	growth hormone	CHEBI:29016	2688	Chemical	Gene	secretion|compound|START_ENTITY affect|nmod|secretion affect|nsubj|secretion secretion|compound|END_ENTITY	Nocturnal growth_hormone secretion does not affect diurnal variations in arginine and glucose-stimulated insulin secretion .
2114512	0	arginine	83,91	growth_hormone	55,69	arginine	growth hormone	CHEBI:29016	2688	Chemical	Gene	exercise|compound|START_ENTITY responses|nmod|exercise responses|amod|END_ENTITY	Reduced sensitivity to pirenzepine-induced blockade of growth_hormone responses to arginine , exercise , and growth_hormone-releasing hormone in type I diabetic subjects .
26059749	0	arginine	121,129	growth_hormone	41,55	arginine	growth hormone	CHEBI:29016	2688	Chemical	Gene	administration|compound|START_ENTITY isoforms|nmod|administration ratio|parataxis|isoforms ratio|acl|circulating circulating|dobj|levels levels|nmod|END_ENTITY	Unaltered ratio of circulating levels of growth_hormone / GH isoforms in adults with Prader-Willi_syndrome after GHRH plus arginine administration .
3554869	0	arginine	65,73	growth_hormone	103,117	arginine	growth hormone	CHEBI:29016	2688	Chemical	Gene	infusion|amod|START_ENTITY infusion|nmod|levels levels|nmod|END_ENTITY	Circulating serum phenylalanine concentrations and the effect of arginine infusion on plasma levels of growth_hormone and insulin in treated phenylketonuric children .
4473026	0	arginine	120,128	growth_hormone	76,90	arginine	growth hormone	CHEBI:29016	2688	Chemical	Gene	-RSB-|compound|START_ENTITY comparison|nmod|-RSB- test|dep|comparison test|nmod|study study|nmod|capacity capacity|nmod|secretion secretion|amod|END_ENTITY	-LSB- Propranolol-glucagon stimulation test for the study of reserve capacity of growth_hormone secretion -- a comparison with arginine or insulin stimulation tests -RSB- .
5123985	0	arginine	82,90	growth_hormone	14,28	arginine	growth hormone	CHEBI:29016	2688	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of growth_hormone in vitro on muscle accumulation and incorporation of arginine .
6109991	0	arginine	71,79	growth_hormone	30,44	arginine	growth hormone	CHEBI:29016	2688	Chemical	Gene	Effects|acl|START_ENTITY Effects|nmod|prosomatostatin prosomatostatin|nmod|response response|compound|END_ENTITY	Effects of prosomatostatin on growth_hormone and prolactin response to arginine in man .
641622	0	arginine	72,80	growth_hormone	45,59	arginine	growth hormone	CHEBI:29016	2688	Chemical	Gene	infusion|compound|START_ENTITY effects|nmod|infusion effects|nmod|response response|amod|END_ENTITY	Differential effects of cranial radiation on growth_hormone response to arginine and insulin infusion .
6532933	0	arginine	38,46	growth_hormone	55,69	arginine	growth hormone	CHEBI:29016	2688	Chemical	Gene	hypercalcaemia|nmod|START_ENTITY effect|nmod|hypercalcaemia induced|nsubj|effect induced|dobj|release release|amod|END_ENTITY	The effect of acute hypercalcaemia on arginine induced growth_hormone release in diabetic man .
668153	0	arginine	21,29	growth_hormone	33,47	arginine	growth hormone	CHEBI:29016	2688	Chemical	Gene	START_ENTITY|nmod|children children|amod|END_ENTITY	Glucagon response to arginine in growth_hormone deficient children before and after treatment with growth_hormone and in children with non-endocrine_short_stature .
6746865	0	arginine	62,70	growth_hormone	25,39	arginine	growth hormone	CHEBI:29016	2688	Chemical	Gene	elicited|nmod|START_ENTITY elicited|nsubj|mediation mediation|nmod|secretion secretion|amod|END_ENTITY	Cholinergic mediation of growth_hormone secretion elicited by arginine , clonidine , and physical exercise in man .
6994940	0	arginine	15,23	growth_hormone	55,69	arginine	growth hormone	CHEBI:29016	2688	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of arginine , insulin and metoclopramide on growth_hormone , prolactin and cortisol release in children .
7067169	0	arginine	14,22	growth_hormone	50,64	arginine	growth hormone	CHEBI:29016	2688	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|dep|release release|compound|END_ENTITY	Inhibition of arginine - and hypoglycemia - induced growth_hormone release by acetate in dialyzed patients .
8175969	0	arginine	85,93	growth_hormone	46,60	arginine	growth hormone	CHEBI:29016	2688	Chemical	Gene	improves|nmod|START_ENTITY improves|dobj|response response|compound|END_ENTITY	Chronic baclofen therapy improves the blunted growth_hormone response to intravenous arginine in subjects with spinal_cord_injury .
820711	0	arginine	88,96	growth_hormone	54,68	arginine	growth hormone	CHEBI:29016	2688	Chemical	Gene	hypoglycemia|amod|START_ENTITY induced|nmod|hypoglycemia induced|nsubj|Suppression Suppression|nmod|thyrotropin-releasing_hormone thyrotropin-releasing_hormone|nmod|release release|amod|END_ENTITY	Suppression by thyrotropin-releasing_hormone -LRB- TRH -RRB- of growth_hormone release induced by arginine and insulin-induced hypoglycemia in man .
8241653	0	arginine	23,31	growth_hormone	45,59	arginine	growth hormone	CHEBI:29016	2688	Chemical	Gene	administration|nmod|START_ENTITY enhances|nsubj|administration enhances|dobj|response response|amod|END_ENTITY	Oral administration of arginine enhances the growth_hormone response to growth_hormone_releasing_hormone in short children .
8570858	0	arginine	38,46	growth_hormone	67,81	arginine	growth hormone	CHEBI:29016	2688	Chemical	Gene	secretion|compound|START_ENTITY secretion|compound|END_ENTITY	Differential effects of deltorphin on arginine and galanin-induced growth_hormone secretion in healthy man .
8980159	0	arginine	105,113	growth_hormone	23,37	arginine	growth hormone	CHEBI:29016	2688	Chemical	Gene	START_ENTITY|nsubj|Reproducibility Reproducibility|nmod|response response|amod|END_ENTITY	Reproducibility of the growth_hormone response to stimulation with growth_hormone-releasing_hormone plus arginine during lifespan .
956343	0	arginine	114,122	growth_hormone	96,110	arginine	growth hormone	CHEBI:29016	2688	Chemical	Gene	infusion|amod|START_ENTITY END_ENTITY|nmod|infusion	Effect of the antihistaminic agents meclastine and dexchlorpheniramine on the response of human growth_hormone to arginine infusion and insulin hypoglycemia .
993322	0	arginine	90,98	growth_hormone	63,77	arginine	growth hormone	CHEBI:29016	2688	Chemical	Gene	pimozide|dep|START_ENTITY pimozide|nmod|response response|amod|END_ENTITY	Effect of the dopamine receptor blocking agent pimozide on the growth_hormone response to arginine and exercise and on the spontaneous growth_hormone fluctuations .
10633218	0	arginine	59,67	insulin	12,19	arginine	insulin	CHEBI:29016	3630	Chemical	Gene	induced|nmod|START_ENTITY secretion|acl|induced inhibits|dobj|secretion inhibits|nsubj|END_ENTITY	Circulating insulin inhibits glucagon secretion induced by arginine in type 1 diabetes .
1171746	0	arginine	65,73	insulin	15,22	arginine	insulin	CHEBI:29016	3630	Chemical	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|reactions reactions|compound|END_ENTITY	-LSB- Comparison of insulin reactions in various diseases to glucose , arginine , and glucagon -RSB- .
1182245	0	arginine	54,62	insulin	21,28	arginine	insulin	CHEBI:29016	3630	Chemical	Gene	serum|advcl|START_ENTITY serum|dobj|response response|compound|END_ENTITY	Blood glucose , serum insulin and glucagon response to arginine in premature infants .
1206104	0	arginine	91,99	insulin	152,159	arginine	insulin	CHEBI:29016	3630	Chemical	Gene	fasting|nmod|START_ENTITY Normalization|acl|fasting Normalization|nmod|infusion infusion|nmod|END_ENTITY	Normalization of fasting hyperglucagonemia and excessive glucagon responses to intravenous arginine in human diabetes_mellitus by prolonged infusion of insulin .
1207275	0	arginine	11,19	insulin	23,30	arginine	insulin	CHEBI:29016	3630	Chemical	Gene	START_ENTITY|nmod|liberation liberation|compound|END_ENTITY	-LSB- Effect of arginine on insulin liberation during intra-abdominal operations -RSB- .
12399273	0	arginine	5,13	insulin	48,55	arginine	insulin	CHEBI:29016	3630	Chemical	Gene	stimulate|nsubj|START_ENTITY stimulate|nmod|concentration concentration|compound|END_ENTITY	Oral arginine does not stimulate an increase in insulin concentration but delays glucose disposal .
1254112	0	arginine	58,66	insulin	10,17	arginine	insulin	CHEBI:29016	3630	Chemical	Gene	Effect|acl|START_ENTITY Effect|nmod|END_ENTITY	Effect of insulin on the exaggerated glucagon response to arginine stimulation in diabetes_mellitus .
1262446	0	arginine	72,80	insulin	24,31	arginine	insulin	CHEBI:29016	3630	Chemical	Gene	stimulation|acl|START_ENTITY stimulation|nmod|END_ENTITY	Xylitol : stimulation of insulin and inhibition of glucagon responses to arginine in man .
1761067	0	arginine	78,86	insulin	58,65	arginine	insulin	CHEBI:29016	3630	Chemical	Gene	Effect|acl|START_ENTITY Effect|nmod|nifedipine nifedipine|nmod|potentiation potentiation|nmod|response response|compound|END_ENTITY	Effect of nifedipine on glucose potentiation of the acute insulin response to arginine in non-insulin-dependent diabetics .
1988776	0	arginine	73,81	insulin	105,112	arginine	insulin	CHEBI:29016	3630	Chemical	Gene	secretion|compound|START_ENTITY secretion|compound|END_ENTITY	Nocturnal growth_hormone secretion does not affect diurnal variations in arginine and glucose-stimulated insulin secretion .
22848214	0	arginine	22,30	insulin	60,67	arginine	insulin	CHEBI:29016	280829(Tax:9913)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|aggregation aggregation|nmod|END_ENTITY	Inhibitory effects of arginine on the aggregation of bovine insulin .
23935755	0	arginine	52,60	insulin	15,22	arginine	insulin	CHEBI:29016	3630	Chemical	Gene	administration|compound|START_ENTITY secretion|nmod|administration secretion|nsubj|Stimulation Stimulation|nmod|END_ENTITY	Stimulation of insulin secretion by large-dose oral arginine administration in healthy adults .
2885161	0	arginine	47,55	insulin	108,115	arginine	insulin	CHEBI:29016	3630	Chemical	Gene	START_ENTITY|nmod|infusion infusion|compound|END_ENTITY	Plasma immunoreactive somatostatin response to arginine after glycemic control with continuous subcutaneous insulin infusion in type I diabetics .
3073905	0	arginine	49,57	insulin	26,33	arginine	insulin	CHEBI:29016	3630	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|stimulation stimulation|nmod|END_ENTITY	Repetitive stimulation of insulin secretion with arginine and glucose .
3081885	3	arginine	657,665	insulin	632,639	arginine	insulin	CHEBI:29016	3630	Chemical	Gene	test|amod|START_ENTITY level|nmod|test level|compound|END_ENTITY	A peak rise of insulin after glucose administration was absent in patients managed with SLD , whereas an insulin level during the arginine test reached 302 + / - 12.7 pmol/l .
3288227	0	arginine	76,84	insulin	100,107	arginine	insulin	CHEBI:29016	3630	Chemical	Gene	relation|nmod|START_ENTITY relation|nmod|END_ENTITY	Testing a mechanism of control in human cholesterol metabolism : relation of arginine and glycine to insulin and glucagon .
492415	0	arginine	52,60	insulin	12,19	arginine	insulin	CHEBI:29016	3630	Chemical	Gene	Response|acl|START_ENTITY Response|nmod|END_ENTITY	Response of insulin , glucagon and growth_hormone to arginine infusion in patients with chronic_renal_failure .
499636	0	arginine	44,52	insulin	24,31	arginine	insulin	CHEBI:29016	3630	Chemical	Gene	Effect|acl|START_ENTITY Effect|nmod|calcitonin calcitonin|nmod|response response|compound|END_ENTITY	Effect of calcitonin on insulin response to arginine in man .
6146518	0	arginine	53,61	insulin	81,88	arginine	insulin	CHEBI:29016	3630	Chemical	Gene	Ala-2-D-Trp-8-D-Cys-14-somatostatin|nmod|START_ENTITY Effect|nmod|Ala-2-D-Trp-8-D-Cys-14-somatostatin induced|nsubj|Effect induced|dobj|release release|nmod|END_ENTITY	Effect of Ala-2-D-Trp-8-D-Cys-14-somatostatin on the arginine induced release of insulin , GH and glucagon in normal men .
6342632	0	arginine	43,51	insulin	22,29	arginine	insulin	CHEBI:29016	3630	Chemical	Gene	secretion|xcomp|START_ENTITY secretion|nsubj|response response|nmod|END_ENTITY	-LSB- Biphasic response of insulin secretion to arginine stimulation : daily changes -RSB- .
6348222	0	arginine	36,44	insulin	13,20	arginine	insulin	CHEBI:29016	3630	Chemical	Gene	hypercalciuria|amod|START_ENTITY Evidence|nmod|hypercalciuria Evidence|nmod|involvement involvement|compound|END_ENTITY	Evidence for insulin involvement in arginine - and glucose-induced hypercalciuria in the rat .
6370761	0	arginine	65,73	insulin	29,36	arginine	insulin	CHEBI:29016	3630	Chemical	Gene	effect|amod|START_ENTITY suppression|nmod|effect inhibition|dep|suppression inhibition|nmod|release release|compound|END_ENTITY	Time-dependent inhibition of insulin release : suppression of the arginine effect by hyperglycaemia .
680309	0	arginine	27,35	insulin	7,14	arginine	insulin	CHEBI:29016	3630	Chemical	Gene	START_ENTITY|nsubj|response response|compound|END_ENTITY	Plasma insulin response to arginine stimulation in children and adolescents with constitutional short stature according to sex , age , sexual development and skinfold thickness .
6993547	0	arginine	55,63	insulin	22,29	arginine	insulin	CHEBI:29016	3630	Chemical	Gene	Blood|xcomp|START_ENTITY Blood|dobj|END_ENTITY	Blood glucose , plasma insulin and glucagon response to arginine in infants during the first month of life .
6993600	0	arginine	11,19	insulin	50,57	arginine	insulin	CHEBI:29016	105613195	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|release release|nmod|END_ENTITY	Effects of arginine and glucose on the release of insulin in the sheep fetus .
6998800	0	arginine	58,66	insulin	24,31	arginine	insulin	CHEBI:29016	3630	Chemical	Gene	Effect|acl|START_ENTITY Effect|nmod|furosemide furosemide|nmod|responses responses|compound|END_ENTITY	Effect of furosemide on insulin and glucagon responses to arginine in normal subjects .
7001174	0	arginine	72,80	insulin	45,52	arginine	insulin	CHEBI:29016	3630	Chemical	Gene	infusion|amod|START_ENTITY concentrations|nmod|infusion concentrations|nmod|END_ENTITY	Portal and peripheral vein concentrations of insulin and glucagon after arginine infusion in morbidly obese subjects .
7479680	0	arginine	11,19	insulin	40,47	arginine	insulin	CHEBI:29016	3630	Chemical	Gene	START_ENTITY|nmod|secretion secretion|nmod|END_ENTITY	Effects of arginine on the secretion of insulin and islet amyloid polypeptide in humans .
9059567	0	arginine	31,39	insulin	66,73	arginine	insulin	CHEBI:29016	3630	Chemical	Gene	nitric_oxide|nmod|START_ENTITY Involvement|nmod|nitric_oxide induced|nsubj|Involvement induced|dobj|secretion secretion|compound|END_ENTITY	Involvement of nitric_oxide in arginine , but not glucose , induced insulin secretion in normal men .
9356021	0	arginine	55,63	insulin	11,18	arginine	insulin	CHEBI:29016	3630	Chemical	Gene	Diminished|xcomp|START_ENTITY Diminished|dobj|responses responses|compound|END_ENTITY	Diminished insulin and glucagon secretory responses to arginine in nondiabetic subjects with a mutation in the hepatocyte_nuclear_factor-4alpha / MODY1 gene .
946565	2	arginine	99,107	insulin	127,134	arginine	insulin	CHEBI:29016	3630	Chemical	Gene	somatostatin|nmod|START_ENTITY Effect|nmod|somatostatin induced|nsubj|Effect induced|dobj|release release|nmod|END_ENTITY	Effect of somatostatin on arginine induced release of insulin and glucagon in man and perfused rat pancreas .
976604	0	arginine	99,107	insulin	17,24	arginine	insulin	CHEBI:29016	3630	Chemical	Gene	responses|nmod|START_ENTITY Effects|nmod|responses Effects|nmod|withdrawal withdrawal|compound|END_ENTITY	Effects of acute insulin withdrawal and administration on plasma glucagon responses to intravenous arginine in insulin-dependent diabetic subjects .
976605	0	arginine	36,44	insulin	16,23	arginine	insulin	CHEBI:29016	3630	Chemical	Gene	response|dep|START_ENTITY response|compound|END_ENTITY	Imparied plasma insulin response to arginine in hyperthyroidism .
12429874	0	arginine	45,53	leptin	20,26	arginine	leptin	CHEBI:29016	3952	Chemical	Gene	plasma|nmod|START_ENTITY plasma|dobj|concentrations concentrations|compound|END_ENTITY	Reduction of plasma leptin concentrations by arginine but not lipid infusion in humans .
18424593	0	arginine	8,16	mTOR	43,47	arginine	mTOR	CHEBI:29016	21977(Tax:10090)	Chemical	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	Dietary arginine supplementation increases mTOR signaling activity in skeletal muscle of neonatal pigs .
18616983	0	arginine	31,39	mTOR	85,89	arginine	mTOR	CHEBI:29016	21977(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|expression expression|nmod|pathway pathway|compound|END_ENTITY	Branched-chain amino_acids and arginine suppress MaFbx/atrogin -1 mRNA expression via mTOR pathway in C2C12 cell line .
25605596	0	arginine	23,31	neuraminidase	44,57	arginine	neuraminidase	CHEBI:29016	4758	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Targeting a cluster of arginine residues of neuraminidase to avoid oseltamivir resistance in influenza A -LRB- H1N1 -RRB- : a theoretical study .
15230885	0	arginine	19,27	p53	15,18	arginine	p53	CHEBI:29016	7157	Chemical	Gene	START_ENTITY|nsubj|Association Association|nmod|END_ENTITY	Association of p53 arginine polymorphism with skin_cancer .
18249029	0	arginine	95,103	p53	91,94	arginine	p53	CHEBI:29016	7157	Chemical	Gene	variant|compound|START_ENTITY variant|compound|END_ENTITY	Arsenic-induced health effects and genetic_damage in keratotic individuals : involvement of p53 arginine variant and chromosomal_aberrations in arsenic susceptibility .
11467957	0	arginine	38,46	parathyroid_hormone	50,69	arginine	parathyroid hormone	CHEBI:29016	5741	Chemical	Gene	requirements|nmod|START_ENTITY requirements|nmod|END_ENTITY	Structural requirements for conserved arginine of parathyroid_hormone .
24814653	0	arginine	15,23	phosphorylase_kinase	42,62	arginine	phosphorylase kinase	CHEBI:29016	5256	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Dual effect of arginine on aggregation of phosphorylase_kinase .
21700716	0	arginine	65,73	programmed_cell_death_4	110,133	arginine	programmed cell death 4	CHEBI:29016	27250	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	Protein_arginine_methyltransferase_5 accelerates tumor growth by arginine methylation of the tumor suppressor programmed_cell_death_4 .
16321272	0	arginine	44,52	proinsulin	15,25	arginine	proinsulin	CHEBI:29016	3630	Chemical	Gene	stimulation|amod|START_ENTITY END_ENTITY|nmod|stimulation	-LSB- Proportion of proinsulin two minutes after arginine stimulation : a pilot study -RSB- .
19152634	0	arginine	61,69	relaxin-3	77,86	arginine	relaxin-3	CHEBI:29016	117579	Chemical	Gene	START_ENTITY|nmod|antagonist antagonist|amod|END_ENTITY	The structural and functional role of the B-chain C-terminal arginine in the relaxin-3 peptide antagonist , R3 -LRB- BDelta23-27 -RRB- R/I5 .
24615237	0	arginine	152,160	relaxin-3	173,182	arginine	relaxin-3	CHEBI:29016	117579	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	The highly conserved negatively charged Glu141 and Asp145 of the G-protein-coupled receptor RXFP3 interact with the highly conserved positively charged arginine residues of relaxin-3 .
1116481	0	arginine	105,113	somatostatin	14,26	arginine	somatostatin	CHEBI:29016	24797(Tax:10116)	Chemical	Gene	response|nmod|START_ENTITY pancreas|nmod|response release|nmod|pancreas END_ENTITY|nmod|release	Inhibition by somatostatin of glucagon and insulin release from the perfused rat pancreas in response to arginine , isoproterenol and theophylline : evidence for a preferential effect on glucagon secretion .
2862561	0	arginine	20,28	somatostatin	62,74	arginine	somatostatin	CHEBI:29016	24797(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY secretion|compound|END_ENTITY	Vagal modulation of arginine - and glucagon-induced pancreatic somatostatin secretion .
2862561	3	arginine	657,665	somatostatin	491,503	arginine	somatostatin	CHEBI:29016	24797(Tax:10116)	Chemical	Gene	presence|nmod|START_ENTITY enhanced|nmod|presence atropine|dep|enhanced eliminated|dobj|atropine eliminated|nsubjpass|effect effect|nmod|END_ENTITY	This suppressive effect on somatostatin was eliminated in the presence of 10 -LRB- -5 -RRB- M atropine plus glucagon , while somatostatin release was significantly enhanced in the presence of atropine plus arginine .
2884887	0	arginine	68,76	somatostatin	19,31	arginine	somatostatin	CHEBI:29016	403993(Tax:9615)	Chemical	Gene	determining|advcl|START_ENTITY END_ENTITY|acl|determining	Role of pancreatic somatostatin in determining glucagon response to arginine and morphine .
6103639	0	arginine	93,101	somatostatin	39,51	arginine	somatostatin	CHEBI:29016	24797(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY release|acl|induced release|compound|END_ENTITY	Sulphonylurea -LRB- glubenclamide -RRB- enhances somatostatin and inhibits glucagon release induced by arginine .
14567685	0	arginine	28,36	sulfite_oxidase	86,101	arginine	sulfite oxidase	CHEBI:29016	6821	Chemical	Gene	START_ENTITY|nmod|transfer transfer|nmod|END_ENTITY	Essential role of conserved arginine 160 in intramolecular electron transfer in human sulfite_oxidase .
681365	0	arginine	20,28	tRNA	29,33	arginine	tRNA	CHEBI:29016	2777576(Tax:10726)	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Localization of the arginine tRNA gene to the D segment of T5 bacteriophage DNA .
10669563	0	arginine	87,95	thrombin	24,32	arginine	thrombin	CHEBI:29016	2147	Chemical	Gene	-2|amod|START_ENTITY contains|dobj|-2 ligand|acl:relcl|contains selectivity|nmod|ligand selectivity|compound|END_ENTITY	Structural basis of the thrombin selectivity of a ligand that contains the constrained arginine mimic -LRB- 2S -RRB- -2 - amino - -LRB- 3S -RRB- -3 - -LRB- 1-carbamimidoyl - _ piperidin-3-yl -RRB- - propanoic_acid at P1 .
10915051	0	arginine	104,112	thrombin	28,36	arginine	thrombin	CHEBI:29016	2147	Chemical	Gene	surrogates|nmod|START_ENTITY containing|dobj|surrogates analogues|acl|containing design|dep|analogues design|nmod|inhibitors inhibitors|compound|END_ENTITY	The design and synthesis of thrombin inhibitors : analogues of MD805 containing non-polar surrogates for arginine at the P1 position .
11459667	0	arginine	76,84	thrombin	114,122	arginine	thrombin	CHEBI:29016	2147	Chemical	Gene	analogues|nmod|START_ENTITY substitution|nmod|analogues induced|nmod|substitution induced|nmod|inhibitors inhibitors|compound|END_ENTITY	Selectivity enhancement induced by substitution of non-natural analogues of arginine and lysine in arginine-based thrombin inhibitors .
11971909	0	arginine	18,26	thrombin	118,126	arginine	thrombin	CHEBI:29016	2147	Chemical	Gene	interaction|amod|START_ENTITY Elimination|nmod|interaction activates|nsubj|Elimination activates|dobj|III III|nmod|inhibition inhibition|compound|END_ENTITY	Elimination of P1 arginine 393 interaction with underlying glutamic_acid 255 partially activates antithrombin III for thrombin inhibition but not factor_Xa inhibition .
15890436	0	arginine	99,107	thrombin	32,40	arginine	thrombin	CHEBI:29016	2147	Chemical	Gene	mimetics|nsubj|START_ENTITY incorporating|parataxis|mimetics incorporating|nsubj|inhibitors inhibitors|compound|END_ENTITY	Novel pyrazinone and pyridinone thrombin inhibitors incorporating weakly basic heterobicyclic P -LRB- 1 -RRB- - arginine mimetics .
2128973	0	arginine	93,101	thrombin	109,117	arginine	thrombin	CHEBI:29016	100009146(Tax:9986)	Chemical	Gene	156|amod|START_ENTITY cleaved|nmod|156 cleaved|nmod|END_ENTITY	Fibrin specific thrombolysis by two-chain urokinase-type plasminogen activator cleaved after arginine 156 by thrombin .
2506948	0	arginine	3,11	thrombin	62,70	arginine	thrombin	CHEBI:29016	2147	Chemical	Gene	amino_acid|nsubj|START_ENTITY amino_acid|nmod|site site|compound|END_ENTITY	An arginine to cysteine amino_acid substitution at a critical thrombin cleavage site in a dysfunctional factor_VIII molecule .
5891215	0	arginine	48,56	thrombin	24,32	arginine	thrombin	CHEBI:29016	2147	Chemical	Gene	activity|nmod|START_ENTITY activity|nmod|END_ENTITY	Comparative activity of thrombin on substituted arginine and lysine esters .
7117668	0	arginine	103,111	thrombin	14,22	arginine	thrombin	CHEBI:29016	2147	Chemical	Gene	residues|amod|START_ENTITY interaction|nmod|residues Inhibition|dep|interaction Inhibition|nmod|cleavage cleavage|compound|END_ENTITY	Inhibition of thrombin cleavage of fibrinogen by polyestradiol_phosphate ; interaction with the crucial arginine residues in fibrinogen required for enzymic cleavage .
7582980	0	arginine	62,70	thrombin	44,52	arginine	thrombin	CHEBI:29016	2147	Chemical	Gene	based|nmod|START_ENTITY END_ENTITY|acl|based	Amide and alpha-keto_carbonyl inhibitors of thrombin based on arginine and lysine : synthesis , stability and biological characterization .
8027055	0	arginine	156,164	thrombin	124,132	arginine	thrombin	CHEBI:29016	2147	Chemical	Gene	includes|xcomp|START_ENTITY site|acl:relcl|includes site|nmod|END_ENTITY	Glycosaminoglycan contributions to both protein C activation and thrombin inhibition involve a common arginine-rich site in thrombin that includes residues arginine 93 , 97 , and 101 .
11741329	0	arginine	35,43	vasopressin	44,55	arginine	vasopressin	CHEBI:29016	551	Chemical	Gene	regulation|amod|START_ENTITY regulation|compound|END_ENTITY	Role of glucocorticoid hormones in arginine vasopressin gene regulation .
15844504	0	arginine	40,48	vasopressin	49,60	arginine	vasopressin	CHEBI:29016	551	Chemical	Gene	olfactory_neuroblastoma|amod|START_ENTITY olfactory_neuroblastoma|amod|END_ENTITY	Expression of somatostatin receptors in arginine vasopressin hormone-secreting olfactory_neuroblastoma -- report of two cases .
16060916	0	arginine	47,55	vasopressin	56,67	arginine	vasopressin	CHEBI:29016	551	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Expression of three different mutations in the arginine vasopressin gene suggests genotype-phenotype correlation in familial_neurohypophyseal_diabetes_insipidus kindreds .
20447579	0	arginine	94,102	vasopressin	103,114	arginine	vasopressin	CHEBI:29016	551	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|compound|END_ENTITY	The critical link of hypervolemia and hyponatremia in heart_failure and the potential role of arginine vasopressin antagonists .
10764763	0	arginine_129	8,20	antithrombin	58,70	arginine 129	antithrombin	null	462	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of arginine_129 in heparin binding and activation of antithrombin .
10644716	0	arginine_172	10,22	apolipoprotein_E	41,57	arginine 172	apolipoprotein E	null	348	Chemical	Gene	START_ENTITY|nmod|the the|nmod|END_ENTITY	Effect of arginine_172 on the binding of apolipoprotein_E to the low_density_lipoprotein_receptor .
10782866	0	arginine_butyrate	45,62	interleukin-2	17,30	arginine butyrate	interleukin-2	MESH:C033018	3558	Chemical	Gene	START_ENTITY|nsubj|trial trial|nmod|END_ENTITY	Phase I trial of interleukin-2 and high-dose arginine_butyrate in metastatic colorectal_cancer .
7597721	0	arginine_ester	52,66	fibrinogen	21,31	arginine ester	fibrinogen	null	2244	Chemical	Gene	degradation|nmod|START_ENTITY degradation|compound|END_ENTITY	Comparative study of fibrinogen degradation by four arginine_ester hydrolases from the venom of Agkistrodon caliginosus -LRB- Kankoku-Mamushi -RRB- .
16520824	0	arginine_vasopressin	24,44	AVPR1a	58,64	arginine vasopressin	AVPR1a	MESH:D001127	552	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association between the arginine_vasopressin 1a receptor -LRB- AVPR1a -RRB- gene and autism in a family-based study : mediation by socialization skills .
18655900	0	arginine_vasopressin	33,53	AVPR1a	67,73	arginine vasopressin	AVPR1a	MESH:D001127	552	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Molecular genetic studies of the arginine_vasopressin 1a receptor -LRB- AVPR1a -RRB- and the oxytocin_receptor -LRB- OXTR -RRB- in human behaviour : from autism to altruism with some notes in between .
19195791	0	arginine_vasopressin	20,40	AVPR1a	54,60	arginine vasopressin	AVPR1a	MESH:D001127	552	Chemical	Gene	receptor|amod|START_ENTITY Association|nmod|receptor Association|appos|END_ENTITY	Association between arginine_vasopressin 1a receptor -LRB- AVPR1a -RRB- promoter region polymorphisms and prepulse inhibition .
6251105	0	arginine_vasopressin	138,158	Adrenocorticotropin	0,19	arginine vasopressin	Adrenocorticotropin	MESH:D001127	5443	Chemical	Gene	extract|appos|START_ENTITY effect|nmod|extract secretion|dep|effect secretion|compound|END_ENTITY	Adrenocorticotropin and lipotropin secretion by dispersed cell cultures of a human corticotropic adenoma : effect of hypothalamic extract , arginine_vasopressin , hydrocortisone , and serotonin .
2139164	0	arginine_vasopressin	80,100	Atrial_natriuretic_peptide	0,26	arginine vasopressin	Atrial natriuretic peptide	MESH:D001127	24602(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY acute_renal_failure|acl|induced reverses|dobj|acute_renal_failure reverses|nsubj|END_ENTITY	Atrial_natriuretic_peptide reverses experimental acute_renal_failure induced by arginine_vasopressin .
3031746	0	arginine_vasopressin	76,96	Atrial_natriuretic_peptide	0,26	arginine vasopressin	Atrial natriuretic peptide	MESH:D001127	24602(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY affect|dobj|release affect|nsubj|END_ENTITY	Atrial_natriuretic_peptide does not affect corticotropin-releasing factor - , arginine_vasopressin - and angiotensin_II-induced adrenocorticotropic hormone release in vivo or in vitro .
17515850	0	arginine_vasopressin	34,54	Copeptin	0,8	arginine vasopressin	Copeptin	MESH:D001127	551	Chemical	Gene	precursor|compound|START_ENTITY peptide|nmod|precursor END_ENTITY|appos|peptide	Copeptin , a stable peptide of the arginine_vasopressin precursor , is elevated in hemorrhagic and septic_shock .
23624546	0	arginine_vasopressin	33,53	Copeptin	0,8	arginine vasopressin	Copeptin	MESH:D001127	551	Chemical	Gene	marker|nmod|START_ENTITY END_ENTITY|appos|marker	Copeptin , a surrogate marker for arginine_vasopressin , is associated with declining glomerular filtration in patients with diabetes_mellitus -LRB- ZODIAC-33 -RRB- .
23757433	0	arginine_vasopressin	33,53	Copeptin	0,8	arginine vasopressin	Copeptin	MESH:D001127	551	Chemical	Gene	marker|nmod|START_ENTITY END_ENTITY|appos|marker	Copeptin , a surrogate marker for arginine_vasopressin , is associated with cardiovascular and all-cause mortality in patients with type 2 diabetes -LRB- ZODIAC-31 -RRB- .
24533694	0	arginine_vasopressin	33,53	Copeptin	0,8	arginine vasopressin	Copeptin	MESH:D001127	551	Chemical	Gene	secretion|compound|START_ENTITY marker|nmod|secretion END_ENTITY|appos|marker	Copeptin , a surrogate marker for arginine_vasopressin secretion , is associated with higher glucose and insulin concentrations but not higher blood pressure in obese men .
24628831	0	arginine_vasopressin	33,53	Copeptin	0,8	arginine vasopressin	Copeptin	MESH:D001127	551	Chemical	Gene	marker|nmod|START_ENTITY END_ENTITY|appos|marker	Copeptin , a surrogate marker for arginine_vasopressin , is associated with cardiovascular_risk in patients with polycystic_ovary_syndrome .
24926317	0	arginine_vasopressin	69,89	Fos	51,54	arginine vasopressin	Fos	MESH:D001127	314322(Tax:10116)	Chemical	Gene	neurons|compound|START_ENTITY expression|nmod|neurons expression|compound|END_ENTITY	Copulation or sensory cues from the female augment Fos expression in arginine_vasopressin neurons of the posterodorsal medial amygdala of male rats .
7953699	0	arginine_vasopressin	42,62	Interleukin-2	0,13	arginine vasopressin	Interleukin-2	MESH:D001127	116562(Tax:10116)	Chemical	Gene	secretion|nmod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Interleukin-2 stimulates the secretion of arginine_vasopressin but not corticotropin-releasing_hormone from rat hypothalamic cells in vitro .
18655900	0	arginine_vasopressin	33,53	OXTR	102,106	arginine vasopressin	OXTR	MESH:D001127	5021	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Molecular genetic studies of the arginine_vasopressin 1a receptor -LRB- AVPR1a -RRB- and the oxytocin_receptor -LRB- OXTR -RRB- in human behaviour : from autism to altruism with some notes in between .
7901784	0	arginine_vasopressin	62,82	Pituitary_adenylate_cyclase-activating_polypeptide	0,50	arginine vasopressin	Pituitary adenylate cyclase-activating polypeptide	MESH:D001127	24166(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Pituitary_adenylate_cyclase-activating_polypeptide stimulates arginine_vasopressin release in conscious rats .
12829429	0	arginine_vasopressin	39,59	SM22_alpha	14,24	arginine vasopressin	SM22 alpha	MESH:D001127	6876	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of SM22_alpha expression by arginine_vasopressin and PDGF-BB in vascular smooth muscle cells .
828136	0	arginine_vasopressin	23,43	TRH	10,13	arginine vasopressin	TRH	MESH:D001127	7200	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of TRH on serum arginine_vasopressin in euthyroid and hypothyroid subjects .
1560825	0	arginine_vasopressin	46,66	V1a	42,45	arginine vasopressin	V1a	MESH:D001127	25107(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Molecular cloning and expression of a rat V1a arginine_vasopressin receptor .
9521539	0	arginine_vasopressin	16,36	V1a	37,40	arginine vasopressin	V1a	MESH:D001127	25107(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Localisation of arginine_vasopressin V1a receptors on sympatho-adrenal preganglionic neurones .
1332907	0	arginine_vasopressin	33,53	adrenocorticotropin	72,91	arginine vasopressin	adrenocorticotropin	MESH:D001127	5443	Chemical	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	Evidence that the stimulation by arginine_vasopressin of the release of adrenocorticotropin from the ovine anterior pituitary involves the activation of protein_kinase_C .
7052927	0	arginine_vasopressin	68,88	angiotensin_II	10,24	arginine vasopressin	angiotensin II	MESH:D001127	24179(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY infusion|nmod|release infusion|nsubj|Effect Effect|nmod|END_ENTITY	Effect of angiotensin_II infusion into rat hepatic portal vessel on arginine_vasopressin release .
7943439	0	arginine_vasopressin	50,70	atrial_natriuretic_factor	10,35	arginine vasopressin	atrial natriuretic factor	MESH:D001127	100294648(Tax:9940)	Chemical	Gene	release|nmod|START_ENTITY Effect|nmod|release Effect|nmod|END_ENTITY	Effect of atrial_natriuretic_factor on release of arginine_vasopressin and renin in fetal lambs .
10535700	0	arginine_vasopressin	172,192	atrial_natriuretic_peptide	53,79	arginine vasopressin	atrial natriuretic peptide	MESH:D001127	24602(Tax:10116)	Chemical	Gene	rats|nmod|START_ENTITY END_ENTITY|nmod|rats	Vascular , renal , and endocrine responses to low-dose atrial_natriuretic_peptide in the fluid-balanced New Zealand genetically hypertensive rats with and without endogenous arginine_vasopressin .
1667640	0	arginine_vasopressin	11,31	atrial_natriuretic_peptide	64,90	arginine vasopressin	atrial natriuretic peptide	MESH:D001127	24602(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY osmolarity|nsubj|Effects osmolarity|nmod|release release|amod|END_ENTITY	Effects of arginine_vasopressin and extracellular osmolarity on atrial_natriuretic_peptide release by superfused rat atria .
2526745	0	arginine_vasopressin	10,30	atrial_natriuretic_peptide	61,87	arginine vasopressin	atrial natriuretic peptide	MESH:D001127	608289(Tax:9615)	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of arginine_vasopressin on urine formation and plasma atrial_natriuretic_peptide level in conscious dogs .
1526063	0	arginine_vasopressin	11,31	brain_natriuretic_peptide	83,108	arginine vasopressin	brain natriuretic peptide	MESH:D001127	25105(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|release release|nmod|END_ENTITY	Effects of arginine_vasopressin , angiotensin_II and endothelin-1 on the release of brain_natriuretic_peptide in vivo and in vitro .
17635944	0	arginine_vasopressin	54,74	copeptin	18,26	arginine vasopressin	copeptin	MESH:D001127	551	Chemical	Gene	portion|nmod|START_ENTITY END_ENTITY|appos|portion	Changes in plasma copeptin , the c-terminal portion of arginine_vasopressin during water deprivation and excess in healthy subjects .
20386508	0	arginine_vasopressin	51,71	copeptin	7,15	arginine vasopressin	copeptin	MESH:D001127	551	Chemical	Gene	infusion|compound|START_ENTITY END_ENTITY|nmod|infusion	Plasma copeptin levels before and during exogenous arginine_vasopressin infusion in patients with advanced vasodilatory_shock .
3871693	0	arginine_vasopressin	37,57	corticotropin-releasing_factor	124,154	arginine vasopressin	corticotropin-releasing factor	MESH:D001127	81648(Tax:10116)	Chemical	Gene	modulation|nmod|START_ENTITY secretion|nsubj|modulation secretion|nmod|END_ENTITY	Central modulation of immunoreactive arginine_vasopressin and oxytocin secretion into the hypophysial-portal circulation by corticotropin-releasing_factor .
2546964	0	arginine_vasopressin	82,102	corticotropin-releasing_hormone	28,59	arginine vasopressin	corticotropin-releasing hormone	MESH:D001127	1392	Chemical	Gene	response|compound|START_ENTITY Effect|nmod|response Effect|nmod|END_ENTITY	Effect of administration of corticotropin-releasing_hormone and glucocorticoid on arginine_vasopressin response to osmotic stimulus in normal subjects and patients with hypocorticotropinism without overt diabetes_insipidus .
8612481	0	arginine_vasopressin	48,68	neuropeptide_FF	23,38	arginine vasopressin	neuropeptide FF	MESH:D001127	60337(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY inhibits|dobj|release inhibits|nsubj|END_ENTITY	Centrally administered neuropeptide_FF inhibits arginine_vasopressin release in conscious rats .
2494281	0	arginine_vasopressin	51,71	ornithine_decarboxylase	15,38	arginine vasopressin	ornithine decarboxylase	MESH:D001127	24609(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Stimulation of ornithine_decarboxylase activity by arginine_vasopressin in the rat medullary thick ascending limb of Henle 's loop .
26388166	0	arginine_vasopressin	50,70	oxytocin	16,24	arginine vasopressin	oxytocin	MESH:D001127	18429(Tax:10090)	Chemical	Gene	Distribution|nmod|START_ENTITY Distribution|nmod|END_ENTITY	Distribution of oxytocin and co-localization with arginine_vasopressin in the brain of mice .
26388166	0	arginine_vasopressin	50,70	oxytocin	16,24	arginine vasopressin	oxytocin	MESH:D001127	18429(Tax:10090)	Chemical	Gene	Distribution|nmod|START_ENTITY Distribution|nmod|END_ENTITY	Distribution of oxytocin and co-localization with arginine_vasopressin in the brain of mice .
7579131	0	arginine_vasopressin	87,107	pituitary_adenylate_cyclase-activating_polypeptide	33,83	arginine vasopressin	pituitary adenylate cyclase-activating polypeptide	MESH:D001127	116	Chemical	Gene	secretion|compound|START_ENTITY END_ENTITY|nmod|secretion	Effects of intravenously infused pituitary_adenylate_cyclase-activating_polypeptide on arginine_vasopressin and oxytocin secretion in man .
7106949	7	arginine_vasopressin	1087,1107	renin	1077,1082	arginine vasopressin	renin	MESH:D001127	24715(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	The vasodilatory effect of K depletion appears to be a direct effect on vascular smooth muscle since it is associated with an increase in total body Na as well as an increase in cardiac output and in renin ane arginine_vasopressin levels .
963956	0	arginine_vasopressin	16,36	renin	48,53	arginine vasopressin	renin	MESH:D001127	5972	Chemical	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	The response of arginine_vasopressin and plasma renin to postural change in normal man , with observations on syncope .
10515439	0	arginine_vasopressin	73,93	transforming_growth_factor-beta1	14,46	arginine vasopressin	transforming growth factor-beta1	MESH:D001127	59086(Tax:10116)	Chemical	Gene	action|nmod|START_ENTITY END_ENTITY|nmod|action	Inhibition by transforming_growth_factor-beta1 of the cellular action of arginine_vasopressin in cultured rat glomerular mesangial cells .
19914332	0	arginine_vasotocin	41,59	TonEBP	0,6	arginine vasotocin	TonEBP	MESH:D014668	415866(Tax:9031)	Chemical	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	TonEBP regulates hyperosmolality-induced arginine_vasotocin gene expression in the chick -LRB- Gallus_domesticus -RRB- .
2887428	0	arginines	30,39	D-amino-acid_oxidase	53,73	arginines	D-amino-acid oxidase	null	1610	Chemical	Gene	modification|nmod|START_ENTITY modification|nmod|END_ENTITY	Phenylglyoxal modification of arginines in mammalian D-amino-acid_oxidase .
354693	0	arginyl	8,15	hexokinase	34,44	arginyl	hexokinase	CHEBI:22619	851167(Tax:4932)	Chemical	Gene	residues|amod|START_ENTITY Role|nmod|residues END_ENTITY|nsubj|Role	Role of arginyl residues in yeast hexokinase PII .
10820008	2	arginyl	65,72	myelin_basic_protein	85,105	arginyl	myelin basic protein	CHEBI:22619	618684(Tax:9913)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Effect of deimination of arginyl residues of myelin_basic_protein on its structure and susceptibility to digestion by cathepsin_D .
22563718	0	argon	67,72	CO2	44,47	argon	CO2	MESH:D001128	717	Chemical	Gene	complexes|nmod|START_ENTITY complexes|compound|END_ENTITY	Infrared characterization of the HCOOH CO2 complexes in solid argon : stabilization of the higher-energy conformer of formic_acid .
17242925	0	aripiprazole	39,51	5-HT1A	57,63	aripiprazole	5-HT1A	MESH:C094645	3350	Chemical	Gene	START_ENTITY|nmod|receptors receptors|compound|END_ENTITY	Interaction of the novel antipsychotic aripiprazole with 5-HT1A and 5-HT 2A receptors : functional receptor-binding and in vivo electrophysiological studies .
23277246	0	aripiprazole	11,23	5-HT1A	56,62	aripiprazole	5-HT1A	MESH:C094645	3350	Chemical	Gene	START_ENTITY|nmod|receptors receptors|nummod|END_ENTITY	Effects of aripiprazole , risperidone , and olanzapine on 5-HT1A receptors in patients with schizophrenia .
24905516	0	aripiprazole	17,29	BDNF	148,152	aripiprazole	BDNF	MESH:C094645	24225(Tax:10116)	Chemical	Gene	environment|amod|START_ENTITY environment|nmod|END_ENTITY	The influence of aripiprazole , olanzapine and enriched environment on depressant-like behavior , spatial memory_dysfunction and hippocampal level of BDNF in prenatally stressed rats .
24682161	0	aripiprazole	107,119	CYP2D6	36,42	aripiprazole	CYP2D6	MESH:C094645	1565	Chemical	Gene	concentrations|nmod|START_ENTITY Effects|nmod|concentrations Effects|nmod|END_ENTITY	Effects of genetic polymorphisms of CYP2D6 , CYP3A5 , and ABCB1 on the steady-state plasma concentrations of aripiprazole and its active metabolite , dehydroaripiprazole , in Japanese patients with schizophrenia .
23066770	0	aripiprazole	32,44	Prolactin	0,9	aripiprazole	Prolactin	MESH:C094645	5617	Chemical	Gene	treatment|amod|START_ENTITY concentrations|nmod|treatment concentrations|compound|END_ENTITY	Prolactin concentrations during aripiprazole treatment in relation to sex , plasma drugs concentrations and genetic polymorphisms of dopamine_D2_receptor and cytochrome_P450_2D6 in Japanese patients with schizophrenia .
23647135	0	aripiprazole	38,50	Prolactin	0,9	aripiprazole	Prolactin	MESH:C094645	5617	Chemical	Gene	treatment|amod|START_ENTITY serum|nmod|treatment serum|nsubj|END_ENTITY	Prolactin serum concentrations during aripiprazole treatment in youth .
19038534	0	aripiprazole	11,23	prolactin	27,36	aripiprazole	prolactin	MESH:C094645	5617	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Effects of aripiprazole on prolactin levels in subjects with schizophrenia during cross-titration with risperidone or olanzapine : analysis of a randomized , open-label study .
9708344	0	aristeromycin	52,65	S-adenosyl-L-homocysteine_hydrolase	106,141	aristeromycin	S-adenosyl-L-homocysteine hydrolase	MESH:C030034	191	Chemical	Gene	Synthesis|nmod|START_ENTITY Synthesis|nmod|END_ENTITY	Synthesis of homologated halovinyl derivatives from aristeromycin and their inhibition of human placental S-adenosyl-L-homocysteine_hydrolase .
7857307	0	aristeromycin	113,126	S-adenosylhomocysteine_hydrolase	69,101	aristeromycin	S-adenosylhomocysteine hydrolase	MESH:C030034	191	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Induction of erythroid differentiation in leukaemic K562 cells by an S-adenosylhomocysteine_hydrolase inhibitor , aristeromycin .
10657963	0	aristolochic_acid	61,78	H-ras	92,97	aristolochic acid	H-ras	MESH:C000228	15461(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Using polymerase arrest to detect DNA binding specificity of aristolochic_acid in the mouse H-ras gene .
1322178	0	aristolochic_acid	47,64	phospholipase_A2	19,35	aristolochic acid	phospholipase A2	MESH:C000228	151056	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|inhibitors inhibitors|amod|END_ENTITY	The effects of the phospholipase_A2 inhibitors aristolochic_acid and PGBx on A23187-stimulated mobilization of arachidonate in human neutrophils are overcome by diacylglycerol or phorbol_ester .
2536283	0	aristolochic_acid	11,28	phospholipase_A2	32,48	aristolochic acid	phospholipase A2	MESH:C000228	151056	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|amod|END_ENTITY	Effects of aristolochic_acid on phospholipase_A2 activity and arachidonate metabolism of human neutrophils .
21980933	0	aristolochic_acid_I	91,110	organic_anion_transporters_1_and_3	17,51	aristolochic acid I	organic anion transporters 1 and 3	MESH:C000228	18399;19879	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Critical role of organic_anion_transporters_1_and_3 in kidney accumulation and toxicity of aristolochic_acid_I .
20630766	0	aromathecin	59,70	topoisomerase_I	71,86	aromathecin	topoisomerase I	null	7150	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	The structure-activity relationships of A-ring-substituted aromathecin topoisomerase_I inhibitors strongly support a camptothecin-like binding mode .
22102023	0	aromatic_acid	32,45	PA4019	13,19	aromatic acid	PA4019	null	878992(Tax:208964)	Chemical	Gene	START_ENTITY|nsubj|Structure Structure|nmod|END_ENTITY	Structure of PA4019 , a putative aromatic_acid decarboxylase from Pseudomonas_aeruginosa .
25765309	0	aromatic_aldehyde	57,74	transketolase	33,46	aromatic aldehyde	transketolase	CHEBI:33855	7086	Chemical	Gene	substrates|compound|START_ENTITY END_ENTITY|nmod|substrates	Second generation engineering of transketolase for polar aromatic_aldehyde substrates .
24410629	0	aromatic_amines	67,82	cytochrome_P450_1A2	86,105	aromatic amines	cytochrome P450 1A2	CHEBI:33860	1544	Chemical	Gene	studies|nmod|START_ENTITY studies|nmod|END_ENTITY	Theoretical studies of the mechanism of N-hydroxylation of primary aromatic_amines by cytochrome_P450_1A2 : radicaloid or anionic ?
3567888	0	aromatic_amines	40,55	ornithine_decarboxylase	13,36	aromatic amines	ornithine decarboxylase	CHEBI:33860	24609(Tax:10116)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of ornithine_decarboxylase by aromatic_amines in rat liver .
6706937	0	aromatic_amino_acids	19,39	phenylalanine_hydroxylase	55,80	aromatic amino acids	phenylalanine hydroxylase	CHEBI:33856	24616(Tax:10116)	Chemical	Gene	interaction|nmod|START_ENTITY END_ENTITY|nsubj|interaction	The interaction of aromatic_amino_acids with rat liver phenylalanine_hydroxylase .
26213029	0	aromatic_heterocycle_thiosemicarbazone	31,69	tyrosinase	94,104	aromatic heterocycle thiosemicarbazone	tyrosinase	null	7299	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	Inhibitory effect of synthetic aromatic_heterocycle_thiosemicarbazone derivatives on mushroom tyrosinase : Insights from fluorescence , -LRB- 1 -RRB- H NMR titration and molecular docking studies .
2097280	0	aromatic_hydrocarbon	42,62	AHH	76,79	aromatic hydrocarbon	AHH	null	24296(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	-LSB- Effects of age and selected inductors of aromatic_hydrocarbon hydroxylase -LRB- AHH -RRB- activity in the rat liver -RSB- .
23528250	0	aromatic_hydrocarbon	23,43	AHR	54,57	aromatic hydrocarbon	AHR	null	196	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Genetic association of aromatic_hydrocarbon receptor -LRB- AHR -RRB- and cytochrome_P450 , _ family_1 , subfamily_A , polypeptide_1 -LRB- CYP1A1 -RRB- polymorphisms with dioxin blood concentrations among pregnant Japanese women .
23528250	0	aromatic_hydrocarbon	23,43	CYP1A1	118,124	aromatic hydrocarbon	CYP1A1	null	1543	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Genetic association of aromatic_hydrocarbon receptor -LRB- AHR -RRB- and cytochrome_P450 , _ family_1 , subfamily_A , polypeptide_1 -LRB- CYP1A1 -RRB- polymorphisms with dioxin blood concentrations among pregnant Japanese women .
2482144	0	arotinolol	10,20	atrial_natriuretic_peptide	48,74	arotinolol	atrial natriuretic peptide	MESH:C024523	24602(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of arotinolol on hemodynamics and plasma atrial_natriuretic_peptide at rest and during stress in spontaneously hypertensive rats .
7535191	0	arotinolol	10,20	insulin	24,31	arotinolol	insulin	MESH:C024523	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|sensitivity sensitivity|compound|END_ENTITY	Effect of arotinolol on insulin sensitivity in obese hypertensive patients .
2428551	0	arotinolol	11,21	renin	70,75	arotinolol	renin	MESH:C024523	24715(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|release release|compound|END_ENTITY	Effects of arotinolol , an alpha - and beta-adrenoceptor antagonist , on renin release from rat kidney cortical slices .
2458109	0	arotinolol	11,21	renin	65,70	arotinolol	renin	MESH:C024523	403838(Tax:9615)	Chemical	Gene	Effects|nmod|START_ENTITY induced|nsubj|Effects induced|dobj|release release|compound|END_ENTITY	Effects of arotinolol on hemodynamics and adrenergically induced renin release and renal vasoconstriction .
19602204	0	arrestin	35,43	Adaptor_protein-2	0,17	arrestin	Adaptor protein-2	MESH:D019393	7020	Chemical	Gene	interaction|nmod|START_ENTITY interaction|amod|END_ENTITY	Adaptor_protein-2 interaction with arrestin regulates GPCR recycling and apoptosis .
1386362	0	arrestin	12,20	rhodopsin	66,75	arrestin	rhodopsin	MESH:D019393	6010	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of arrestin and retinoids in the regeneration pathway of rhodopsin .
21266531	0	arsenic	57,64	ABCB6	37,42	arsenic	ABCB6	MESH:D001151	74104(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	The ATP-binding cassette transporter ABCB6 is induced by arsenic and protects against arsenic_cytotoxicity .
26928318	0	arsenic	120,127	AS3MT	85,90	arsenic	AS3MT	MESH:D001151	57412	Chemical	Gene	metabolism|compound|START_ENTITY relation|nmod|metabolism END_ENTITY|nmod|relation	Analysis of maternal polymorphisms in arsenic -LRB- +3 oxidation state -RRB- - methyltransferase AS3MT and fetal sex in relation to arsenic metabolism and infant birth outcomes : Implications for risk analysis .
25944616	0	arsenic	72,79	Akt	29,32	arsenic	Akt	MESH:D001151	207	Chemical	Gene	promotes|nmod|START_ENTITY promotes|nsubj|phosphorylation phosphorylation|nmod|END_ENTITY	Filamin_A phosphorylation by Akt promotes cell migration in response to arsenic .
25944616	0	arsenic	72,79	Akt	29,32	arsenic	Akt	MESH:D001151	207	Chemical	Gene	promotes|nmod|START_ENTITY promotes|nsubj|phosphorylation phosphorylation|nmod|END_ENTITY	Filamin_A phosphorylation by Akt promotes cell migration in response to arsenic .
26563149	0	arsenic	46,53	AtPCS1	18,24	arsenic	AtPCS1	MESH:D001151	831845(Tax:3702)	Chemical	Gene	increases|dobj|START_ENTITY increases|nsubj|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of AtPCS1 in tobacco increases arsenic and arsenic plus cadmium accumulation and detoxification .
23562784	0	arsenic	41,48	Cyclin_D1	23,32	arsenic	Cyclin D1	MESH:D001151	595	Chemical	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Regulation of cellular Cyclin_D1 gene by arsenic is mediated through miR-2909 .
23644288	0	arsenic	39,46	NALP2	15,20	arsenic	NALP2	MESH:D001151	55655	Chemical	Gene	polymorphism|nmod|START_ENTITY polymorphism|compound|END_ENTITY	Association of NALP2 polymorphism with arsenic induced skin_lesions and other health effects .
14567983	0	arsenic	50,57	Nrf2	21,25	arsenic	Nrf2	MESH:D001151	4780	Chemical	Gene	activation|nmod|START_ENTITY END_ENTITY|acl|activation	Transcription factor Nrf2 activation by inorganic arsenic in cultured keratinocytes : involvement of hydrogen_peroxide .
23738048	0	arsenic	44,51	Nrf2	18,22	arsenic	Nrf2	MESH:D001151	4780	Chemical	Gene	pathway|nmod|START_ENTITY pathway|amod|END_ENTITY	Activation of the Nrf2 pathway by inorganic arsenic in human hepatocytes and the role of transcriptional repressor Bach1 .
16479312	0	arsenic	50,57	Organic_anion_transporting_polypeptide-C	0,40	arsenic	Organic anion transporting polypeptide-C	MESH:D001151	10599	Chemical	Gene	uptake|compound|START_ENTITY mediates|dobj|uptake mediates|nsubj|END_ENTITY	Organic_anion_transporting_polypeptide-C mediates arsenic uptake in HEK-293 cells .
12919957	0	arsenic	39,46	P53	0,3	arsenic	P53	MESH:D001151	7157	Chemical	Gene	bladder_tumors|nmod|START_ENTITY alterations|nmod|bladder_tumors alterations|nummod|END_ENTITY	P53 alterations in bladder_tumors from arsenic and tobacco exposed patients .
20036271	0	arsenic	151,158	P53	60,63	arsenic	P53	MESH:D001151	7157	Chemical	Gene	exposure|compound|START_ENTITY associated|nmod|exposure carcinogenesis|acl|associated mechanism|nmod|carcinogenesis induced|nmod|mechanism induced|dobj|ation ation|nmod|END_ENTITY	Arsenite induced poly -LRB- ADP-ribosyl -RRB- ation of tumor suppressor P53 in human skin keratinocytes as a possible mechanism for carcinogenesis associated with arsenic exposure .
21864978	0	arsenic	28,35	aox	10,13	arsenic	aox	MESH:D001151	51	Chemical	Gene	genotype|nmod|START_ENTITY genotype|compound|END_ENTITY	Bacterial aox genotype from arsenic contaminated mine to adjacent coastal sediment : evidences for potential biogeochemical arsenic oxidation .
16968895	0	arsenic	54,61	aquaglyceroporin_9	30,48	arsenic	aquaglyceroporin 9	MESH:D001151	366	Chemical	Gene	uptake|compound|START_ENTITY END_ENTITY|nmod|uptake	Relationship of expression of aquaglyceroporin_9 with arsenic uptake and sensitivity in leukemia cells .
19100828	0	arsenic	49,56	aquaglyceroporin_9	10,28	arsenic	aquaglyceroporin 9	MESH:D001151	366	Chemical	Gene	resistance|compound|START_ENTITY disrupts|dobj|resistance disrupts|nsubj|expression expression|amod|END_ENTITY	Increased aquaglyceroporin_9 expression disrupts arsenic resistance in human lung_cancer cells .
19033395	0	arsenic	152,159	aryl_hydrocarbon_receptor	50,75	arsenic	aryl hydrocarbon receptor	MESH:D001151	196	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of oxidative stress and activation of aryl_hydrocarbon_receptor in elevation of CYP1A1 expression and activity in lung cells and tissues by arsenic : an in vitro and in vivo study .
11852569	0	arsenic	11,18	atpase	59,65	arsenic	atpase	MESH:D001151	1769	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	-LSB- Effect of arsenic on bacterial growth and plasma membrane atpase activity -RSB- .
19429254	0	arsenic	60,67	epidermal_growth_factor_receptor	14,46	arsenic	epidermal growth factor receptor	MESH:D001151	24329(Tax:10116)	Chemical	Gene	inhibitor|nmod|START_ENTITY inhibitor|compound|END_ENTITY	Effects of an epidermal_growth_factor_receptor inhibitor on arsenic associated toxicity in the rat bladder epithelium .
22955273	0	arsenic	90,97	hAS3MT	138,144	arsenic	hAS3MT	MESH:D001151	57412	Chemical	Gene	_|compound|START_ENTITY _|appos|END_ENTITY	Rapid equilibrium kinetic analysis of arsenite methylation catalyzed by recombinant human arsenic _ -LRB- +3 _ oxidation_state -RRB- _ methyltransferase -LRB- hAS3MT -RRB- .
26598702	0	arsenic	96,103	hexokinase-2	67,79	arsenic	hexokinase-2	MESH:D001151	3099	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|END_ENTITY	Systematic identification of arsenic-binding proteins reveals that hexokinase-2 is inhibited by arsenic .
24434654	0	arsenic	23,30	mdig	53,57	arsenic	mdig	MESH:D001151	84864	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|acl|END_ENTITY	Carcinogenic metalloid arsenic induces expression of mdig oncogene through JNK and STAT3 activation .
23073540	0	arsenic	14,21	p16	80,83	arsenic	p16	MESH:D001151	1029	Chemical	Gene	exposure|compound|START_ENTITY exposure|nmod|END_ENTITY	Environmental arsenic exposure and DNA methylation of the tumor suppressor gene p16 and the DNA repair gene MLH1 : effect of arsenic metabolism and genotype .
14971643	0	arsenic	87,94	p53	0,3	arsenic	p53	MESH:D001151	7157	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	p53 expression in circulating lymphocytes of non-melanoma_skin_cancer patients from an arsenic contaminated region in Mexico .
17567589	0	arsenic	16,23	p53	0,3	arsenic	p53	MESH:D001151	7157	Chemical	Gene	exposure|compound|START_ENTITY response|nmod|exposure response|compound|END_ENTITY	p53 response to arsenic exposure in epithelial cells : protein_kinase_B / Akt involvement .
17718444	0	arsenic	68,75	p53	30,33	arsenic	p53	MESH:D001151	7157	Chemical	Gene	-RSB-|compound|START_ENTITY exposed|nmod|-RSB- workers|acl|exposed damage|nmod|workers damage|compound|END_ENTITY	-LSB- Real-time PCR used to detect p53 gene damage in workers exposed to arsenic -RSB- .
18085531	0	arsenic	52,59	p53	34,37	arsenic	p53	MESH:D001151	7157	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Attenuation of DNA damage-induced p53 expression by arsenic : a possible mechanism for arsenic co-carcinogenesis .
18085531	0	arsenic	86,93	p53	34,37	arsenic	p53	MESH:D001151	7157	Chemical	Gene	co-carcinogenesis|compound|START_ENTITY mechanism|nmod|co-carcinogenesis Attenuation|dep|mechanism Attenuation|nmod|expression expression|compound|END_ENTITY	Attenuation of DNA damage-induced p53 expression by arsenic : a possible mechanism for arsenic co-carcinogenesis .
18621066	0	arsenic	58,65	p53	30,33	arsenic	p53	MESH:D001151	7157	Chemical	Gene	plant|compound|START_ENTITY workers|nmod|plant gene|nmod|workers gene|compound|END_ENTITY	Increased damage of exon 5 of p53 gene in workers from an arsenic plant .
19010883	0	arsenic	76,83	p53	41,44	arsenic	p53	MESH:D001151	7157	Chemical	Gene	exposure|compound|START_ENTITY levels|nmod|exposure mechanism|nmod|levels Induction|dep|mechanism Induction|nmod|accumulation accumulation|nmod|END_ENTITY	Induction of cytoplasmic accumulation of p53 : a mechanism for low levels of arsenic exposure to predispose cells for malignant transformation .
21454520	0	arsenic	34,41	p53	7,10	arsenic	p53	MESH:D001151	7157	Chemical	Gene	targeted|nmod|START_ENTITY targeted|nsubjpass|protein protein|compound|END_ENTITY	Mutant p53 protein is targeted by arsenic for degradation and plays a role in arsenic-mediated growth suppression .
21550362	0	arsenic	15,22	p53	51,54	arsenic	p53	MESH:D001151	7157	Chemical	Gene	damage|compound|START_ENTITY damage|nmod|gene gene|compound|END_ENTITY	Metabolites of arsenic and increased DNA damage of p53 gene in arsenic plant workers .
21550362	0	arsenic	63,70	p53	51,54	arsenic	p53	MESH:D001151	7157	Chemical	Gene	workers|compound|START_ENTITY Metabolites|nmod|workers Metabolites|nmod|damage damage|nmod|gene gene|compound|END_ENTITY	Metabolites of arsenic and increased DNA damage of p53 gene in arsenic plant workers .
26772154	0	arsenic	50,57	p53	35,38	arsenic	p53	MESH:D001151	7157	Chemical	Gene	methylation|compound|START_ENTITY induced|nmod|methylation induced|nsubj|LincRNAs LincRNAs|nmod|END_ENTITY	LincRNAs and base modifications of p53 induced by arsenic methylation in workers .
9224745	0	arsenic	85,92	p53	0,3	arsenic	p53	MESH:D001151	7157	Chemical	Gene	exposure|compound|START_ENTITY _|nmod|exposure _|nsubj|expression expression|compound|END_ENTITY	p53 expression and proliferative activity in Bowen 's _ disease with or without chronic arsenic exposure .
23352504	0	arsenic_trioxide	61,77	AKT	14,17	arsenic trioxide	AKT	MESH:C006632	207	Chemical	Gene	induced|nmod|START_ENTITY apoptosis|acl|induced enhances|dobj|apoptosis enhances|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of AKT enhances mitotic cell apoptosis induced by arsenic_trioxide .
17331470	0	arsenic_trioxide	21,37	ASK1	0,4	arsenic trioxide	ASK1	MESH:C006632	4217	Chemical	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	ASK1 is activated by arsenic_trioxide in leukemic cells through accumulation of reactive oxygen species and may play a negative role in induction of apoptosis .
15316930	0	arsenic_trioxide	45,61	Akt	26,29	arsenic trioxide	Akt	MESH:C006632	207	Chemical	Gene	resistance|amod|START_ENTITY involvement|nmod|resistance END_ENTITY|dep|involvement	Phosphoinositide_3-kinase / Akt involvement in arsenic_trioxide resistance of human leukemia cells .
15916724	0	arsenic_trioxide	19,35	Akt	12,15	arsenic trioxide	Akt	MESH:C006632	11651(Tax:10090)	Chemical	Gene	suppression|amod|START_ENTITY END_ENTITY|nmod|suppression	The role of Akt on arsenic_trioxide suppression of 3T3-L1 preadipocyte differentiation .
21078540	0	arsenic_trioxide	36,52	Akt	101,104	arsenic trioxide	Akt	MESH:C006632	207	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|role role|nmod|END_ENTITY	Genistein potentiates the effect of arsenic_trioxide against human hepatocellular_carcinoma : role of Akt and nuclear factor-kB .
17018029	0	arsenic_trioxide	41,57	Anion_exchanger_2	0,17	arsenic trioxide	Anion exchanger 2	MESH:C006632	6522	Chemical	Gene	action|nmod|START_ENTITY mediates|dobj|action mediates|nsubj|END_ENTITY	Anion_exchanger_2 mediates the action of arsenic_trioxide .
23770046	0	arsenic_trioxide	143,159	EVI1	117,121	arsenic trioxide	EVI1	MESH:C006632	2122	Chemical	Gene	treatment|nmod|START_ENTITY END_ENTITY|nmod|treatment	SUMO1 negatively regulates the transcriptional activity of EVI1 and significantly increases its co-localization with EVI1 after treatment with arsenic_trioxide .
12883650	0	arsenic_trioxide	85,101	Ezrin	0,5	arsenic trioxide	Ezrin	MESH:C006632	7430	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|END_ENTITY	Ezrin , actin and cytoskeleton in apoptosis of esophageal epithelial cells induced by arsenic_trioxide .
11724321	0	arsenic_trioxide	14,30	Hsc	52,55	arsenic trioxide	Hsc	MESH:C006632	2523	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|nmod|END_ENTITY	The effect of arsenic_trioxide on the expression of Hsc and HNF4 in nuclear matrix proteins in HepG2 cells .
15949266	0	arsenic_trioxide	29,45	NF-kappaB	65,74	arsenic trioxide	NF-kappaB	MESH:C006632	4790	Chemical	Gene	dexamethasone|nmod|START_ENTITY Effects|nmod|dexamethasone induced|nsubj|Effects induced|dobj|activation activation|dep|END_ENTITY	-LSB- Effects of dexamethasone on arsenic_trioxide induced apoptosis , NF-kappaB activation and gene expression in lymphoma cell line -RSB- .
15225615	0	arsenic_trioxide	70,86	P53	2,5	arsenic trioxide	P53	MESH:C006632	7157	Chemical	Gene	chemosensitivity|xcomp|START_ENTITY contributes|xcomp|chemosensitivity contributes|nsubj|gene gene|compound|END_ENTITY	A P53 target gene , PIG11 , contributes to chemosensitivity of cells to arsenic_trioxide .
18652763	0	arsenic_trioxide	79,95	PTEN	138,142	arsenic trioxide	PTEN	MESH:C006632	5728	Chemical	Gene	START_ENTITY|nmod|upregulation upregulation|nmod|END_ENTITY	Augmentation by carnosic_acid of apoptosis in human leukaemia cells induced by arsenic_trioxide via upregulation of the tumour suppressor PTEN .
22944098	0	arsenic_trioxide	20,36	Pin1	158,162	arsenic trioxide	Pin1	MESH:C006632	5300	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|transcription transcription|amod|END_ENTITY	Cytotoxic effect of arsenic_trioxide on acute promyelocytic_leukemia cells through suppression of NFkb-dependent induction of hTERT due to down-regulation of Pin1 transcription .
19925860	0	arsenic_trioxide	25,41	Syk	0,3	arsenic trioxide	Syk	MESH:C006632	6850	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Syk is a novel target of arsenic_trioxide -LRB- ATO -RRB- and is involved in the toxic effect of ATO in human neutrophils .
24666483	0	arsenic_trioxide	12,28	TMS1	51,55	arsenic trioxide	TMS1	MESH:C006632	29108	Chemical	Gene	START_ENTITY|nmod|methylation methylation|nmod|gene gene|nummod|END_ENTITY	-LSB- Effects of arsenic_trioxide on the methylation of TMS1 gene in K562 cells -RSB- .
19099632	0	arsenic_trioxide	11,27	VEGFR-3	86,93	arsenic trioxide	VEGFR-3	MESH:C006632	14257(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	-LSB- Effect of arsenic_trioxide on vascular_endothelial_growth_factor-C and its receptor -LRB- VEGFR-3 -RRB- in nude_mice with gastric_cancer -RSB- .
21223737	0	arsenic_trioxide	14,30	annexin_II	69,79	arsenic trioxide	annexin II	MESH:C006632	302	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Influence of arsenic_trioxide and daunorubicin on the expression of annexin_II and fibrinolytic activity in NB4 cells . -RSB-
20302512	0	arsenic_trioxide	86,102	cathepsins_B_and_L	21,39	arsenic trioxide	cathepsins B and L	MESH:C006632	1508;1514	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|role role|nmod|END_ENTITY	Differential role of cathepsins_B_and_L in autophagy-associated cell death induced by arsenic_trioxide in U87 human glioblastoma cells .
25258011	0	arsenic_trioxide	17,33	cyclin_D1	81,90	arsenic trioxide	cyclin D1	MESH:C006632	595	Chemical	Gene	influence|nmod|START_ENTITY influence|nmod|END_ENTITY	The influence of arsenic_trioxide on the cell cycle , apoptosis and expression of cyclin_D1 in the Jurkat cell line .
22944098	0	arsenic_trioxide	20,36	hTERT	126,131	arsenic trioxide	hTERT	MESH:C006632	7015	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Cytotoxic effect of arsenic_trioxide on acute promyelocytic_leukemia cells through suppression of NFkb-dependent induction of hTERT due to down-regulation of Pin1 transcription .
17121928	0	arsenic_trioxide	69,85	mammalian_target_of_rapamycin	14,43	arsenic trioxide	mammalian target of rapamycin	MESH:C006632	2475	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of mammalian_target_of_rapamycin and the p70_S6_kinase by arsenic_trioxide in BCR-ABL-expressing cells .
24729530	0	arsenic_trioxide	150,166	microRNA-200c	82,95	arsenic trioxide	microRNA-200c	MESH:C006632	406985	Chemical	Gene	effects|nmod|START_ENTITY involved|nmod|effects involved|nsubjpass|END_ENTITY	Induction of the mesenchymal_to_epithelial_transition by demethylation - activated microRNA-200c is involved in the anti-migration/invasion effects of arsenic_trioxide on human breast_cancer cells .
16445569	0	arsenic_trioxide	84,100	mitogen-activated_protein_kinase_kinase	14,53	arsenic trioxide	mitogen-activated protein kinase kinase	MESH:C006632	5609	Chemical	Gene	induced|nmod|START_ENTITY apoptosis|acl|induced enhances|dobj|apoptosis enhances|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of mitogen-activated_protein_kinase_kinase enhances apoptosis induced by arsenic_trioxide in human breast_cancer MCF-7 cells .
19444595	0	arsenic_trioxide	110,126	p53	14,17	arsenic trioxide	p53	MESH:C006632	7157	Chemical	Gene	exposed|xcomp|START_ENTITY exposed|nsubj|Modulation Modulation|nmod|END_ENTITY	Modulation of p53 , c-fos , RARE , cyclin_A , and cyclin_D1 expression in human leukemia -LRB- HL-60 -RRB- cells exposed to arsenic_trioxide .
24884809	0	arsenic_trioxide	19,35	p53	87,90	arsenic trioxide	p53	MESH:C006632	7157	Chemical	Gene	resistance|amod|START_ENTITY resistance|acl|mediated mediated|nmod|END_ENTITY	Nutlin-3 overcomes arsenic_trioxide resistance and tumor metastasis mediated by mutant p53 in Hepatocellular_Carcinoma .
24927258	0	arsenic_trioxide	54,70	p53	120,123	arsenic trioxide	p53	MESH:C006632	7157	Chemical	Gene	growth-inhibitory|nmod|START_ENTITY growth-inhibitory|acl|functional functional|dobj|deficiency deficiency|compound|END_ENTITY	Increased growth-inhibitory and cytotoxic activity of arsenic_trioxide in head_and_neck_carcinoma cells with functional p53 deficiency and resistance to EGFR blockade .
12641442	0	arsenic_trioxide	40,56	pyruvate_dehydrogenase	71,93	arsenic trioxide	pyruvate dehydrogenase	MESH:C006632	54704	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|activity activity|amod|END_ENTITY	Reactive oxygen species are involved in arsenic_trioxide inhibition of pyruvate_dehydrogenase activity .
24691991	0	arsenic_trioxide	44,60	thymidylate_synthase	18,38	arsenic trioxide	thymidylate synthase	MESH:C006632	22171(Tax:10090)	Chemical	Gene	Downregulation|nmod|START_ENTITY Downregulation|nmod|END_ENTITY	Downregulation of thymidylate_synthase with arsenic_trioxide in lung_adenocarcinoma .
25335113	0	arsenic_trioxide	51,67	thymidylate_synthase	18,38	arsenic trioxide	thymidylate synthase	MESH:C006632	22171(Tax:10090)	Chemical	Gene	Downregulation|nmod|START_ENTITY Downregulation|nmod|END_ENTITY	Downregulation of thymidylate_synthase and E2F1 by arsenic_trioxide in mesothelioma .
12844409	0	arsenic_trioxide	80,96	vascular_endothelial_growth_factor	34,68	arsenic trioxide	vascular endothelial growth factor	MESH:C006632	7422	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Down-regulation Down-regulation|nmod|expression expression|nmod|END_ENTITY	-LSB- Down-regulation of expression of vascular_endothelial_growth_factor induced by arsenic_trioxide in bone marrow cells of chronic_myeloid_leukemia -RSB- .
17007042	0	arsenic_trioxide	21,37	vascular_endothelial_growth_factor	72,106	arsenic trioxide	vascular endothelial growth factor	MESH:C006632	22339(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Inhibitory effect of arsenic_trioxide on angiogenesis and expression of vascular_endothelial_growth_factor in gastric_cancer .
17997939	0	arsenic_trioxide	12,28	vascular_endothelial_growth_factor	47,81	arsenic trioxide	vascular endothelial growth factor	MESH:C006632	7422	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expressions expressions|nmod|END_ENTITY	-LSB- Effects of arsenic_trioxide on expressions of vascular_endothelial_growth_factor and P-glycoprotein in multidrug resistant leukemia cell line K562/A02 -RSB- .
1409657	0	arsenite	25,33	ArsC	41,45	arsenite	ArsC	MESH:C015001	3978621(Tax:1280)	Chemical	Gene	START_ENTITY|nmod|protein protein|amod|END_ENTITY	Reduction of arsenate to arsenite by the ArsC protein of the arsenic resistance operon of Staphylococcus_aureus plasmid pI258 .
11854143	0	arsenite	101,109	CYP1A1	13,19	arsenite	CYP1A1	MESH:C015001	1543	Chemical	Gene	diminished|nmod|START_ENTITY -LSB-|ccomp|diminished -LSB-|nsubj|Induction Induction|nmod|END_ENTITY	Induction of CYP1A1 and CYP1B1 in T-47D human breast_cancer cells by benzo -LSB- a -RSB- pyrene is diminished by arsenite .
11042089	0	arsenite	10,18	CYP1A4	39,45	arsenite	CYP1A4	MESH:C015001	396052(Tax:9031)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|induction induction|nmod|END_ENTITY	Effect of arsenite on the induction of CYP1A4 and CYP1A5 in cultured chick embryo hepatocytes .
16809336	0	arsenite	30,38	Cyclooxygenase-2	0,16	arsenite	Cyclooxygenase-2	MESH:C015001	5743	Chemical	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Cyclooxygenase-2 induction by arsenite is through a nuclear factor of activated T-cell-dependent pathway and plays an antiapoptotic role in Beas-2B cells .
17450217	0	arsenite	30,38	Cyclooxygenase-2	0,16	arsenite	Cyclooxygenase-2	MESH:C015001	19225(Tax:10090)	Chemical	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Cyclooxygenase-2 induction by arsenite through the IKKbeta/NFkappaB pathway exerts an antiapoptotic effect in mouse epidermal Cl41 cells .
22463588	0	arsenite	34,42	Cyclooxygenase-2	0,16	arsenite	Cyclooxygenase-2	MESH:C015001	19225(Tax:10090)	Chemical	Gene	inhibition|amod|START_ENTITY mediates|dobj|inhibition mediates|nsubj|END_ENTITY	Cyclooxygenase-2 -LRB- COX-2 -RRB- mediates arsenite inhibition of UVB-induced cellular apoptosis in mouse epidermal Cl41 cells .
17606337	0	arsenite	77,85	Cyp1a1	67,73	arsenite	Cyp1a1	MESH:C015001	13076(Tax:10090)	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Transcriptional activation and posttranscriptional modification of Cyp1a1 by arsenite , cadmium , and chromium .
21167264	0	arsenite	101,109	DNMT	11,15	arsenite	DNMT	MESH:C015001	1786	Chemical	Gene	inhibitors|xcomp|START_ENTITY inhibitors|nsubj|Effects Effects|nmod|END_ENTITY	Effects of DNMT and MEK inhibitors on the expression of RECK , MMP-9 , -2 , uPA and VEGF in response to arsenite stimulation in human uroepithelial cells .
11442837	0	arsenite	50,58	Fps1p	21,26	arsenite	Fps1p	MESH:C015001	850683(Tax:4932)	Chemical	Gene	uptake|nmod|START_ENTITY mediates|dobj|uptake mediates|nsubj|END_ENTITY	The glycerol channel Fps1p mediates the uptake of arsenite and antimonite in Saccharomyces_cerevisiae .
20026328	0	arsenite	52,60	Fps1p	27,32	arsenite	Fps1p	MESH:C015001	850683(Tax:4932)	Chemical	Gene	channel|compound|START_ENTITY channel|nsubj|END_ENTITY	The yeast aquaglyceroporin Fps1p is a bidirectional arsenite channel .
18404528	0	arsenite	75,83	HO-1	56,60	arsenite	HO-1	MESH:C015001	15368(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Differential roles for Nrf2 and AP-1 in upregulation of HO-1 expression by arsenite in murine embryonic fibroblasts .
17116751	0	arsenite	105,113	NF-kappaB	92,101	arsenite	NF-kappaB	MESH:C015001	4790	Chemical	Gene	response|amod|START_ENTITY END_ENTITY|nmod|response	IKKbeta programs to turn on the GADD45alpha-MKK4-JNK apoptotic cascade specifically via p50 NF-kappaB in arsenite response .
11150309	0	arsenite	97,105	NF-kappa_B	19,29	arsenite	NF-kappa B	MESH:C015001	4790	Chemical	Gene	induction|nmod|START_ENTITY induction|nsubj|effect effect|nmod|END_ENTITY	Opposite effect of NF-kappa_B and c-Jun_N-terminal_kinase on p53-independent GADD45 induction by arsenite .
11527213	0	arsenite	29,37	Yap1	0,4	arsenite	Yap1	MESH:C015001	855005(Tax:4932)	Chemical	Gene	START_ENTITY|nsubj|restores restores|amod|END_ENTITY	Yap1 overproduction restores arsenite resistance to the ABC transporter deficient mutant ycf1 by activating ACR3 expression .
21945491	0	arsenite	105,113	aquaporin_9	16,27	arsenite	aquaporin 9	MESH:C015001	366	Chemical	Gene	Contribution|nmod|START_ENTITY Contribution|nmod|END_ENTITY	Contribution of aquaporin_9 and multidrug_resistance-associated_protein_2 to differential sensitivity to arsenite between primary cultured chorion and amnion cells prepared from human fetal membranes .
16387740	0	arsenite	80,88	cyclin_D1	57,66	arsenite	cyclin D1	MESH:C015001	595	Chemical	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Essential roles of PI-3K / Akt/IKKbeta/NFkappaB pathway in cyclin_D1 induction by arsenite in JB6 Cl41 cells .
17005224	0	arsenite	58,66	cyclin_D1	13,22	arsenite	cyclin D1	MESH:C015001	595	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of cyclin_D1 by submicromolar concentrations of arsenite in human epidermal keratinocytes .
20420878	0	arsenite	97,105	cyclin_D1	26,35	arsenite	cyclin D1	MESH:C015001	595	Chemical	Gene	promotes|nmod|START_ENTITY promotes|dobj|expression expression|amod|END_ENTITY	p52-Bcl3 complex promotes cyclin_D1 expression in BEAS-2B cells in response to low concentration arsenite .
21726611	0	arsenite	142,150	cyclin_D1	17,26	arsenite	cyclin D1	MESH:C015001	595	Chemical	Gene	concentration|nmod|START_ENTITY induced|nmod|concentration cells|acl|induced tumorigenesis|nmod|cells involved|nmod|tumorigenesis involved|nsubjpass|Up-regulation Up-regulation|nmod|END_ENTITY	Up-regulation of cyclin_D1 by JNK1/c-Jun is involved in tumorigenesis of human_embryo_lung_fibroblast cells induced by a low concentration of arsenite .
23639288	0	arsenite	107,115	cyclooxygenase-2	15,31	arsenite	cyclooxygenase-2	MESH:C015001	5743	Chemical	Gene	exposure|amod|START_ENTITY inhibiting|nmod|exposure suppresses|advcl|inhibiting suppresses|dobj|expression expression|amod|END_ENTITY	p27 suppresses cyclooxygenase-2 expression by inhibiting p38b and p38 - mediated CREB phosphorylation upon arsenite exposure .
11014213	0	arsenite	11,19	estrogen_receptor-alpha	23,46	arsenite	estrogen receptor-alpha	MESH:C015001	2099	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|amod|END_ENTITY	Effects of arsenite on estrogen_receptor-alpha expression and activity in MCF-7 breast_cancer cells .
26104857	0	arsenite	68,76	interleukin-6	40,53	arsenite	interleukin-6	MESH:C015001	3569	Chemical	Gene	augmentation|nmod|START_ENTITY augmentation|nmod|production production|amod|END_ENTITY	Synergistic augmentation of ATP-induced interleukin-6 production by arsenite in HaCaT cells .
9440242	0	arsenite	10,18	metallothionein	93,108	arsenite	metallothionein	MESH:C015001	100304478(Tax:7998)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of arsenite , arsenate , and the herbicide monosodium_methyl_arsonate -LRB- MSMA -RRB- on hepatic metallothionein expression and lipid peroxidation in channel_catfish .
15355704	0	arsenite	17,25	multidrug_resistance-associated_protein_2	53,94	arsenite	multidrug resistance-associated protein 2	MESH:C015001	25303(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|nmod|END_ENTITY	-LSB- Toxic effect of arsenite on the expression of liver multidrug_resistance-associated_protein_2 in rat -RSB- .
210844	0	arsenite	19,27	xanthine_dehydrogenase	72,94	arsenite	xanthine dehydrogenase	MESH:C015001	396025(Tax:9031)	Chemical	Gene	interaction|nmod|START_ENTITY END_ENTITY|nsubj|interaction	The interaction of arsenite with the molybdenum center of chicken liver xanthine_dehydrogenase .
16919048	0	artemisinin	70,81	CAR	53,56	artemisinin	CAR	MESH:C031327	12355(Tax:10090)	Chemical	Gene	induction|nmod|START_ENTITY induction|nsubj|END_ENTITY	In vivo and mechanistic evidence of nuclear receptor CAR induction by artemisinin .
22252826	0	artemisinin	148,159	CYP3A	129,134	artemisinin	CYP3A	MESH:C031327	1576	Chemical	Gene	induction|nmod|START_ENTITY induction|nummod|END_ENTITY	PXR variants and artemisinin use in Vietnamese subjects : frequency distribution and impact on the interindividual variability of CYP3A induction by artemisinin .
23123209	0	artemisinin	48,59	ERK	82,85	artemisinin	ERK	MESH:C031327	24338(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Induction of neurite outgrowth in PC12 cells by artemisinin through activation of ERK and p38 MAPK signaling pathways .
9373657	0	artemisinin	44,55	Nam	90,93	artemisinin	Nam	MESH:C031327	246329	Chemical	Gene	treated|nmod|START_ENTITY treated|nmod|END_ENTITY	Severe and complicated malaria treated with artemisinin , artesunate or artemether in Viet Nam .
22679214	0	artemisinin	47,58	P450	14,18	artemisinin	P450	MESH:C031327	1555	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Evaluation of P450 inhibition and induction by artemisinin antimalarials in human liver microsomes and primary human hepatocytes .
23267137	0	artemisinin	37,48	transferrin	11,22	artemisinin	transferrin	MESH:C031327	7018	Chemical	Gene	conjugates|nmod|START_ENTITY conjugates|compound|END_ENTITY	Effects of transferrin conjugates of artemisinin and artemisinin dimer on breast_cancer cell lines .
24661944	0	artemisinin	21,32	transferrin	101,112	artemisinin	transferrin	MESH:C031327	7018	Chemical	Gene	delivery|nmod|START_ENTITY delivery|nmod|END_ENTITY	Enhanced delivery of artemisinin and its analogues to cancer cells by their adducts with human serum transferrin .
17726528	0	artesunate	128,138	ABCB6	54,59	artesunate	ABCB6	MESH:C039726	10058	Chemical	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	Role of transferrin_receptor and the ABC transporters ABCB6 and ABCB7 for resistance and differentiation of tumor cells towards artesunate .
16701036	0	artesunate	12,22	CD14	26,30	artesunate	CD14	MESH:C039726	12475(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of artesunate on CD14 and toll-like_receptor_4 in peritoneal macrophages of mice with heat_stroke_endotoxemia -RSB- .
22183882	0	artesunate	15,25	EGFR	47,51	artesunate	EGFR	MESH:C039726	1956	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|nmod|END_ENTITY	The effects of artesunate on the expression of EGFR and ABCG2 in A549 human lung_cancer cells and a xenograft model .
18718059	0	artesunate	23,33	VEGF	75,79	artesunate	VEGF	MESH:C039726	7422	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Suppressive effect of artesunate on K562 cell growth and its influence on VEGF expression -RSB- .
19859713	0	artesunate	23,33	vascular_endothelial_growth_factor	57,91	artesunate	vascular endothelial growth factor	MESH:C039726	7422	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	The anti-malaria agent artesunate inhibits expression of vascular_endothelial_growth_factor and hypoxia-inducible factor-1a in human rheumatoid_arthritis fibroblast-like synoviocyte .
3304435	0	aryl_4-guanidinobenzoates	10,35	acrosin	43,50	aryl 4-guanidinobenzoates	acrosin	null	49	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Effect of aryl_4-guanidinobenzoates on the acrosin activity of human spermatozoa .
3514912	0	aryl_4-guanidinobenzoates	76,101	acrosin	34,41	aryl 4-guanidinobenzoates	acrosin	null	49	Chemical	Gene	Synthesis|nmod|START_ENTITY Synthesis|nmod|END_ENTITY	Synthesis and inhibition of human acrosin and trypsin and acute toxicity of aryl_4-guanidinobenzoates .
3643283	0	aryl_azolides	38,51	leukocyte_elastase	16,34	aryl azolides	leukocyte elastase	null	1991	Chemical	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of leukocyte_elastase by aryl_azolides and sulfonate salts .
11707340	0	aryl_hydrocarbon	3,19	AHR	30,33	aryl hydrocarbon	AHR	null	196	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	An aryl_hydrocarbon receptor -LRB- AHR -RRB- homologue from the soft-shell clam , Mya arenaria : evidence that invertebrate AHR homologues lack 2,3,7,8-tetrachlorodibenzo-p-dioxin and beta-naphthoflavone binding .
26913606	0	aryl_hydrocarbon	43,59	AHR	70,73	aryl hydrocarbon	AHR	null	196	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Preventing germ cell death by inactivating aryl_hydrocarbon receptor -LRB- AHR -RRB- .
14757639	0	aryl_hydrocarbon	10,26	AHR-1	4,9	aryl hydrocarbon	AHR-1	null	172788(Tax:6239)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	The AHR-1 aryl_hydrocarbon receptor and its co-factor the AHA-1 aryl_hydrocarbon receptor nuclear translocator specify GABAergic neuron cell fate in C. _ elegans .
9391097	0	aryl_hydrocarbon	38,54	AHR1	75,79	aryl hydrocarbon	AHR1	null	172788(Tax:6239)	Chemical	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Molecular evolution of two vertebrate aryl_hydrocarbon -LRB- dioxin -RRB- receptors -LRB- AHR1 and AHR2 -RRB- and the PAS family .
16042621	0	aryl_hydrocarbon	24,40	AHR1B	0,5	aryl hydrocarbon	AHR1B	null	554265(Tax:7955)	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|appos|receptor	AHR1B , a new functional aryl_hydrocarbon receptor in zebrafish : tandem arrangement of ahr1b and ahr2 genes .
18945501	0	aryl_hydrocarbon	68,84	AhR	95,98	aryl hydrocarbon	AhR	null	196	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Enhancement of hypoxia-induced gene expression in fish liver by the aryl_hydrocarbon receptor -LRB- AhR -RRB- ligand , benzo -LSB- a -RSB- pyrene -LRB- BaP -RRB- .
25216468	0	aryl_hydrocarbon	39,55	AhR	66,69	aryl hydrocarbon	AhR	null	41988(Tax:7227)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Dose - and time-dependent expression of aryl_hydrocarbon receptor -LRB- AhR -RRB- and aryl_hydrocarbon receptor nuclear translocator -LRB- ARNT -RRB- in PCB - , _ B -LSB- a -RSB- P - , and TBT-exposed intertidal copepod Tigriopus_japonicus .
8396713	0	aryl_hydrocarbon	70,86	aryl_hydrocarbon_receptor_nuclear_translocator	12,58	aryl hydrocarbon	aryl hydrocarbon receptor nuclear translocator	null	405	Chemical	Gene	protein|nmod|START_ENTITY protein|compound|END_ENTITY	Role of the aryl_hydrocarbon_receptor_nuclear_translocator protein in aryl_hydrocarbon -LRB- dioxin -RRB- receptor action .
10856296	0	aryl_hydrocarbons	13,30	Mdm2	38,42	aryl hydrocarbons	Mdm2	null	17246(Tax:10090)	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|amod|END_ENTITY	DNA-damaging aryl_hydrocarbons induce Mdm2 expression via p53-independent post-transcriptional mechanisms .
7772257	0	aryl_hydrocarbons	50,67	cytochrome_P450	80,95	aryl hydrocarbons	cytochrome P450	null	13079(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|gene gene|amod|END_ENTITY	cDNA cloning , sequence analysis , and induction by aryl_hydrocarbons of a murine cytochrome_P450 gene , Cyp1b1 .
16041645	0	arylalkanes	36,47	5-HT3_receptor	0,14	arylalkanes	5-HT3 receptor	null	79246(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	5-HT3_receptor blocking activity of arylalkanes isolated from the rhizome of Zingiber officinale .
24039128	0	arylalkyl_isothiocyanates	41,66	GSTA2	21,26	arylalkyl isothiocyanates	GSTA2	null	24422(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Differential hepatic GSTA2 expression of arylalkyl_isothiocyanates in vivo and in vitro : the molecular mechanism of gene induction by phenethyl_isothiocyanate .
18426226	0	arylalkylhydrazine	38,56	monoamine_oxidases_A_and_B	77,103	arylalkylhydrazine	monoamine oxidases A and B	null	4128;4129	Chemical	Gene	inhibition|amod|START_ENTITY studies|nmod|inhibition studies|nmod|END_ENTITY	Structural and mechanistic studies of arylalkylhydrazine inhibition of human monoamine_oxidases_A_and_B .
18227186	0	arylamidine	62,73	T-2307	46,52	arylamidine	T-2307	null	1067369(Tax:209261)	Chemical	Gene	START_ENTITY|nmod|activities activities|nmod|END_ENTITY	In vitro and in vivo antifungal activities of T-2307 , a novel arylamidine .
22252809	0	arylamidine	64,75	T-2307	48,54	arylamidine	T-2307	null	1067369(Tax:209261)	Chemical	Gene	START_ENTITY|nmod|activities activities|nmod|END_ENTITY	In vitro and in vivo antimalarial activities of T-2307 , a novel arylamidine .
16446091	0	arylaminoethyl_amides	28,49	cathepsin_S	79,90	arylaminoethyl amides	cathepsin S	null	1520	Chemical	Gene	Synthesis|nmod|START_ENTITY Synthesis|nmod|END_ENTITY	Synthesis and evaluation of arylaminoethyl_amides as noncovalent inhibitors of cathepsin_S .
16876402	0	arylaminoethyl_amides	21,42	cathepsin_S	72,83	arylaminoethyl amides	cathepsin S	null	1520	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Synthesis and SAR of arylaminoethyl_amides as noncovalent inhibitors of cathepsin_S : P3_cyclic_ethers .
20028393	0	arylcarboxamides	19,35	InhA	64,68	arylcarboxamides	InhA	null	3623	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	3D-QSAR studies of arylcarboxamides with inhibitory activity on InhA using pharmacophore-based alignment .
14592490	0	aryldihydropyridazinones	36,60	PDE3B	113,118	aryldihydropyridazinones	PDE3B	null	5140	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Benzyl_vinylogous_amide substituted aryldihydropyridazinones and aryldimethylpyrazolones as potent and selective PDE3B inhibitors .
7198004	1	arylhydrocarbon	311,326	AHH	340,343	arylhydrocarbon	AHH	null	24296(Tax:10116)	Chemical	Gene	hydroxylase|compound|START_ENTITY hydroxylase|appos|END_ENTITY	The effect of chronic ethanol consumption by rats on hepatic microsomal metabolism of the procarcinogen benzo -LSB- a -RSB- pyrene -LRB- B -LSB- a -RSB- P -RRB- was investigated both with respect to induction of microsomal arylhydrocarbon hydroxylase -LRB- AHH -RRB- activity and activation of B -LSB- a -RSB- P to a mutagen .
20739074	0	arylhydrocarbon	38,53	ER	92,94	arylhydrocarbon	ER	null	100136026(Tax:8022)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	One-way inhibiting cross-talk between arylhydrocarbon receptor -LRB- AhR -RRB- and estrogen_receptor -LRB- ER -RRB- signaling in primary cultures of rainbow_trout hepatocytes .
14723961	0	aryloxyanilide	58,72	peripheral_benzodiazepine_receptor	94,128	aryloxyanilide	peripheral benzodiazepine receptor	null	24230(Tax:10116)	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Design , synthesis and structure-affinity relationships of aryloxyanilide derivatives as novel peripheral_benzodiazepine_receptor ligands .
9622503	0	aryloxymethyl	35,48	caspase-1	22,31	aryloxymethyl	caspase-1	null	834	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Bimodal inhibition of caspase-1 by aryloxymethyl and acyloxymethyl_ketones .
15026055	0	arylpiperazine	58,72	5-HT1A	73,79	arylpiperazine	5-HT1A	null	3350	Chemical	Gene	ligands|amod|START_ENTITY ligands|amod|END_ENTITY	The design and preparation of metabolically protected new arylpiperazine 5-HT1A ligands .
24568298	0	arylpiperazines	23,38	5-HT1a	42,48	arylpiperazines	5-HT1a	null	3350	Chemical	Gene	START_ENTITY|nmod|receptors receptors|amod|END_ENTITY	Binding modes of chain arylpiperazines to 5-HT1a , 5-HT2a and 5-HT7 receptors .
8289207	0	arylpiperazines	44,59	D-2	13,16	arylpiperazines	D-2	null	28503	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Mixed 5-HT1A / D-2 activity of a new model of arylpiperazines : 1-aryl-4 - -LSB- 3 - -LRB- 1,2-dihydronaphthalen-4-yl -RRB- - n-propyl -RSB- piperazines .
16259761	0	arylpiperazines	35,50	serotonin_transporter	75,96	arylpiperazines	serotonin transporter	null	6532	Chemical	Gene	START_ENTITY|nmod|affinity affinity|nmod|END_ENTITY	Design and synthesis of long-chain arylpiperazines with mixed affinity for serotonin_transporter -LRB- SERT -RRB- and 5-HT -LRB- 1A -RRB- receptor .
19447610	0	arylpyrazole	19,31	opioid_receptor-like_1	63,85	arylpyrazole	opioid receptor-like 1	null	4987	Chemical	Gene	START_ENTITY|nmod|antagonists antagonists|amod|END_ENTITY	Discovery of novel arylpyrazole series as potent and selective opioid_receptor-like_1 -LRB- ORL1 -RRB- antagonists .
24044434	0	arylsulfonamide	10,25	ADAM-17	40,47	arylsulfonamide	ADAM-17	null	6868	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|nmod|END_ENTITY	Selective arylsulfonamide inhibitors of ADAM-17 : hit optimization and activity in ovarian_cancer cell models .
19775099	0	arylsulfones	77,89	matrix_metalloproteinase-12	114,141	arylsulfones	matrix metalloproteinase-12	null	4321	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Design , synthesis , biological evaluation , and NMR studies of a new series of arylsulfones as selective and potent matrix_metalloproteinase-12 inhibitors .
26277322	0	asapiprant	60,70	DP1	35,38	asapiprant	DP1	null	5729	Chemical	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Effect of the potent and selective DP1 receptor antagonist , asapiprant -LRB- S-555739 -RRB- , in animal models of allergic_rhinitis and allergic_asthma .
18057697	0	ascochlorin	122,133	Fra-1	23,28	ascochlorin	Fra-1	MESH:C415745	8061	Chemical	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Aberrant expression of Fra-1 in estrogen_receptor-negative breast_cancers and suppression of their propagation in vivo by ascochlorin , an antibiotic that inhibits cellular activator_protein-1 activity .
20558137	5	ascochlorin	948,959	p21	920,923	ascochlorin	pRB	MESH:C415745	5925	Chemical	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Furthermore , we used a chromatin immunoprecipitation assay , RNA interference , and p53-deficient cells to verify that p21 -LRB- WAF1/CIP1 -RRB- induction by ascochlorin is related to transcriptional repression of c-Myc .
23641721	0	ascorbate	107,116	101F6	58,63	ascorbate	101F6	CHEBI:38290	11068	Chemical	Gene	protein|nmod|START_ENTITY protein|nummod|END_ENTITY	Electron transfer reactions of candidate tumor suppressor 101F6 protein , a cytochrome_b561 homologue , with ascorbate and monodehydroascorbate radical .
6317432	0	ascorbate	82,91	ATPase	26,32	ascorbate	ATPase	CHEBI:38290	1769	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activity activity|amod|END_ENTITY	Inhibition of erythrocyte ATPase activity by aclacinomycin and reverse effects of ascorbate on ATPase activity .
6317432	0	ascorbate	82,91	ATPase	95,101	ascorbate	ATPase	CHEBI:38290	1769	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activity activity|compound|END_ENTITY	Inhibition of erythrocyte ATPase activity by aclacinomycin and reverse effects of ascorbate on ATPase activity .
17382205	0	ascorbate	12,21	HIF-1alpha	43,53	ascorbate	HIF-1alpha	CHEBI:38290	3091	Chemical	Gene	START_ENTITY|nmod|modulation modulation|nmod|protein protein|compound|END_ENTITY	The role of ascorbate in the modulation of HIF-1alpha protein and HIF-dependent transcription by chromium -LRB- VI -RRB- and nickel -LRB- II -RRB- .
18509748	0	ascorbate	84,93	HIF-1alpha	43,53	ascorbate	HIF-1alpha	CHEBI:38290	15251(Tax:10090)	Chemical	Gene	Effect|dep|START_ENTITY Effect|nmod|RNA RNA|dep|END_ENTITY	Effect of small interference RNA targeting HIF-1alpha mediated by rAAV combined L : - ascorbate on pancreatic_tumors in athymic mice .
19396871	0	ascorbate	75,84	HIF-1alpha	100,110	ascorbate	HIF-1alpha	CHEBI:38290	3091	Chemical	Gene	START_ENTITY|nmod|relation relation|nmod|END_ENTITY	Cobalt-induced oxidant stress in cultured endothelial cells : prevention by ascorbate in relation to HIF-1alpha .
9224625	0	ascorbate	8,17	NF-kappaB	39,48	ascorbate	NF-kappaB	CHEBI:38290	4790	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Role of ascorbate in the activation of NF-kappaB by tumour necrosis factor-alpha in T-cells .
8917416	0	ascorbate	59,68	PSK	72,75	ascorbate	PSK	CHEBI:38290	9344	Chemical	Gene	Enhancement|nmod|START_ENTITY Enhancement|nmod|END_ENTITY	Enhancement of radical intensity and cytotoxic activity of ascorbate by PSK and lignins .
11036152	0	ascorbate	52,61	SVCT2	121,126	ascorbate	SVCT2	CHEBI:38290	50622(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY concentration|nmod|cultures cultures|acl|expressing expressing|dobj|transporter transporter|compound|END_ENTITY	Sodium-ascorbate cotransport controls intracellular ascorbate concentration in primary astrocyte cultures expressing the SVCT2 transporter .
19232538	0	ascorbate	55,64	SVCT2	78,83	ascorbate	SVCT2	CHEBI:38290	9962	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Macrophage differentiation increases expression of the ascorbate transporter -LRB- SVCT2 -RRB- .
19254685	0	ascorbate	103,112	SVCT2	67,72	ascorbate	SVCT2	CHEBI:38290	9962	Chemical	Gene	protection|nmod|START_ENTITY transporter|dep|protection transporter|appos|END_ENTITY	Oxidized lipoprotein induces the macrophage ascorbate transporter -LRB- SVCT2 -RRB- : protection by intracellular ascorbate against oxidant stress and apoptosis .
19254685	0	ascorbate	44,53	SVCT2	67,72	ascorbate	SVCT2	CHEBI:38290	9962	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Oxidized lipoprotein induces the macrophage ascorbate transporter -LRB- SVCT2 -RRB- : protection by intracellular ascorbate against oxidant stress and apoptosis .
23916956	0	ascorbate	40,49	SVCT2	34,39	ascorbate	SVCT2	CHEBI:38290	9962	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Expression and/or activity of the SVCT2 ascorbate transporter may be decreased in many aggressive_cancers , suggesting potential utility for sodium_bicarbonate and dehydroascorbic_acid in cancer therapy .
14722088	0	ascorbate	56,65	Zat12	24,29	ascorbate	Zat12	CHEBI:38290	836103(Tax:3702)	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	The zinc finger protein Zat12 is required for cytosolic ascorbate peroxidase 1 expression during oxidative stress in Arabidopsis .
2998243	0	ascorbate	60,69	alpha-1-protease_inhibitor	151,177	ascorbate	alpha-1-protease inhibitor	CHEBI:38290	5265	Chemical	Gene	START_ENTITY|nmod|inactivation inactivation|nmod|END_ENTITY	Investigation of the protective effects of the antioxidants ascorbate , cysteine , and dapsone on the phagocyte-mediated oxidative inactivation of human alpha-1-protease_inhibitor in vitro .
3262598	0	ascorbate	55,64	alpha-1-protease_inhibitor	101,127	ascorbate	alpha-1-protease inhibitor	CHEBI:38290	5265	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	Investigation of the effects of oral administration of ascorbate on the functional activity of serum alpha-1-protease_inhibitor and oxidant release by blood phagocytes from cigarette smokers in a placebo-controlled , doubleblind , crossover trial .
16195596	0	ascorbate	10,19	apolipoprotein_e	100,116	ascorbate	apolipoprotein e	CHEBI:38290	348	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of ascorbate on acrolein modification of very low density lipoprotein and uptake of oxidized apolipoprotein_e by hepatocytes .
3335518	0	ascorbate	21,30	dopamine_beta-monooxygenase	60,87	ascorbate	dopamine beta-monooxygenase	CHEBI:38290	280758(Tax:9913)	Chemical	Gene	dependence|amod|START_ENTITY dependence|nmod|END_ENTITY	Demonstration of the ascorbate dependence of membrane-bound dopamine_beta-monooxygenase in adrenal chromaffin granule ghosts .
16731301	0	ascorbate	128,137	glucose_transporter_1	23,44	ascorbate	glucose transporter 1	CHEBI:38290	6513	Chemical	Gene	role|nmod|START_ENTITY expression|dep|role expression|nmod|END_ENTITY	Enhanced expression of glucose_transporter_1 on erythrocyte membrane in hemodialysis patients : the possible role in erythrocyte ascorbate recycling .
17320759	0	ascorbate	90,99	hypoxia-inducible_factor-1_alpha	14,46	ascorbate	hypoxia-inducible factor-1 alpha	CHEBI:38290	3091	Chemical	Gene	cultured|nmod|START_ENTITY cultured|nsubj|Modulation Modulation|nmod|END_ENTITY	Modulation of hypoxia-inducible_factor-1_alpha in cultured primary cells by intracellular ascorbate .
7537554	0	ascorbate	32,41	lactoferrin	15,26	ascorbate	lactoferrin	CHEBI:38290	280846(Tax:9913)	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of lactoferrin with ascorbate and the relationship with bleomycin-dependent DNA damage .
6301495	0	ascorbate	83,92	methemoglobin	64,77	ascorbate	methemoglobin	CHEBI:38290	3048	Chemical	Gene	production|nmod|START_ENTITY production|nmod|END_ENTITY	The production of activated oxygen species by an interaction of methemoglobin with ascorbate .
10340471	0	ascorbate	13,22	peroxidase	23,33	ascorbate	peroxidase	CHEBI:38290	547504(Tax:3847)	Chemical	Gene	Induction|nmod|START_ENTITY END_ENTITY|nsubj|Induction	Induction of ascorbate peroxidase by ethylene and hydrogen_peroxide during growth of cultured soybean cells .
10501032	0	ascorbate	45,54	peroxidase	55,65	ascorbate	peroxidase	CHEBI:38290	816773(Tax:3702)	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Overexpression of an Arabidopsis peroxisomal ascorbate peroxidase gene in tobacco increases protection against oxidative stress .
10647213	0	ascorbate	17,26	peroxidase	41,51	ascorbate	peroxidase	CHEBI:38290	547504(Tax:3847)	Chemical	Gene	Effectiveness|nmod|START_ENTITY END_ENTITY|nsubj|Effectiveness	Effectiveness of ascorbate and ascorbate peroxidase in promoting nitrogen fixation in model systems .
10996251	0	ascorbate	52,61	peroxidase	62,72	ascorbate	peroxidase	CHEBI:38290	816773(Tax:3702)	Chemical	Gene	START_ENTITY|dobj|activity activity|amod|END_ENTITY	The developmental transition to flowering represses ascorbate peroxidase activity and induces enzymatic lipid peroxidation in leaf tissue in Arabidopsis_thaliana .
11483357	0	ascorbate	23,32	peroxidase	33,43	ascorbate	peroxidase	CHEBI:38290	548137(Tax:4513)	Chemical	Gene	Cloning|nmod|START_ENTITY END_ENTITY|nsubj|Cloning	Cloning of peroxisomal ascorbate peroxidase gene from barley and enhanced thermotolerance by overexpressing in Arabidopsis_thaliana .
12427040	0	ascorbate	84,93	peroxidase	55,65	ascorbate	peroxidase	CHEBI:38290	547504(Tax:3847)	Chemical	Gene	sites|amod|START_ENTITY evidence|nmod|sites binding|dep|evidence binding|nmod|END_ENTITY	Substrate binding and catalytic mechanism in ascorbate peroxidase : evidence for two ascorbate binding sites .
12685046	0	ascorbate	25,34	peroxidase	35,45	ascorbate	peroxidase	CHEBI:38290	816773(Tax:3702)	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Effect of temperature on ascorbate peroxidase activity and flowering of Arabidopsis_thaliana ecotypes under different light conditions .
12913166	0	ascorbate	16,25	peroxidase	26,36	ascorbate	peroxidase	CHEBI:38290	543313(Tax:4565)	Chemical	Gene	mutant|amod|START_ENTITY mutant|compound|END_ENTITY	Thylakoid-bound ascorbate peroxidase mutant exhibits impaired electron transport and photosynthetic activity .
16287625	0	ascorbate	72,81	peroxidase	82,92	ascorbate	peroxidase	CHEBI:38290	543959(Tax:4081)	Chemical	Gene	START_ENTITY|dobj|gene gene|amod|END_ENTITY	Molecular cloning , expression and mapping analysis of a novel cytosolic ascorbate peroxidase gene from tomato .
16386429	0	ascorbate	12,21	peroxidase	22,32	ascorbate	peroxidase	CHEBI:38290	101212957	Chemical	Gene	isoenzymes|amod|START_ENTITY isoenzymes|compound|END_ENTITY	Response of ascorbate peroxidase isoenzymes and ascorbate regeneration system to abiotic stresses in Cucumis_sativus_L .
20007290	0	ascorbate	26,35	peroxidase	36,46	ascorbate	peroxidase	CHEBI:38290	816773(Tax:3702)	Chemical	Gene	isoenzymes|amod|START_ENTITY isoenzymes|compound|END_ENTITY	Arabidopsis chloroplastic ascorbate peroxidase isoenzymes play a dual role in photoprotection and gene regulation under photooxidative stress .
20172491	0	ascorbate	68,77	peroxidase	78,88	ascorbate	peroxidase	CHEBI:38290	543313(Tax:4565)	Chemical	Gene	modeling|nmod|START_ENTITY END_ENTITY|nsubj|modeling	In silico characterization and homology modeling of thylakoid-bound ascorbate peroxidase from a drought tolerant wheat cultivar .
21494099	0	ascorbate	55,64	peroxidase	65,75	ascorbate	peroxidase	CHEBI:38290	547504(Tax:3847)	Chemical	Gene	isoforms|amod|START_ENTITY isoforms|compound|END_ENTITY	Nitric_oxide increases the enzymatic activity of three ascorbate peroxidase isoforms in soybean root nodules .
8534847	0	ascorbate	36,45	peroxidase	46,56	ascorbate	peroxidase	CHEBI:38290	816773(Tax:3702)	Chemical	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression of Arabidopsis cytosolic ascorbate peroxidase gene in response to ozone or sulfur_dioxide .
8638916	0	ascorbate	66,75	peroxidase	76,86	ascorbate	peroxidase	CHEBI:38290	547504(Tax:3847)	Chemical	Gene	expression|nmod|START_ENTITY END_ENTITY|nsubj|expression	Heterologous expression and characterization of soybean cytosolic ascorbate peroxidase .
9144965	0	ascorbate	72,81	peroxidase	82,92	ascorbate	peroxidase	CHEBI:38290	816773(Tax:3702)	Chemical	Gene	genes|amod|START_ENTITY genes|compound|END_ENTITY	Photosynthetic electron transport regulates the expression of cytosolic ascorbate peroxidase genes in Arabidopsis during excess light stress .
9237628	0	ascorbate	35,44	peroxidase	45,55	ascorbate	peroxidase	CHEBI:38290	106444911	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Iron triggers a rapid induction of ascorbate peroxidase gene expression in Brassica_napus .
9291097	0	ascorbate	38,47	peroxidase	151,161	ascorbate	peroxidase	CHEBI:38290	816773(Tax:3702)	Chemical	Gene	peroxidases|nsubj|START_ENTITY peroxidases|nmod|structure structure|nmod|types types|nmod|END_ENTITY	From sequence analysis of three novel ascorbate peroxidases from Arabidopsis_thaliana to structure , function and evolution of seven types of ascorbate peroxidase .
9443387	0	ascorbate	32,41	peroxidase	42,52	ascorbate	peroxidase	CHEBI:38290	547504(Tax:3847)	Chemical	Gene	cDNAs|amod|START_ENTITY cDNAs|compound|END_ENTITY	Identification of two cytosolic ascorbate peroxidase cDNAs from soybean leaves and characterization of their products by functional expression in E. _ coli .
23918967	0	ascorbate	34,43	peroxidase_1	44,56	ascorbate	peroxidase 1	CHEBI:38290	839237(Tax:3702)	Chemical	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Auxin induces redox regulation of ascorbate peroxidase_1 activity by S-nitrosylation/denitrosylation balance resulting in changes of root growth pattern in Arabidopsis .
25730478	0	ascorbate	10,19	plasminogen_activator_inhibitor-1	23,56	ascorbate	plasminogen activator inhibitor-1	CHEBI:38290	18787(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effect of ascorbate on plasminogen_activator_inhibitor-1 expression and release from platelets and endothelial cells in an in-vitro model of sepsis .
23740245	0	ascorbic_Acid	27,40	EB1	0,3	ascorbic Acid	EB1	MESH:D001205	22919	Chemical	Gene	elevated|nmod|START_ENTITY elevated|nsubj|levels levels|compound|END_ENTITY	EB1 levels are elevated in ascorbic_Acid -LRB- AA -RRB- - stimulated osteoblasts and mediate cell-cell adhesion-induced osteoblast differentiation .
26783884	0	ascorbic_acid	23,36	CA1	52,55	ascorbic acid	CA1	MESH:D001205	310218(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|pyramidal pyramidal|compound|END_ENTITY	The protective role of ascorbic_acid on hippocampal CA1 pyramidal neurons in a rat model of maternal lead exposure .
17147197	0	ascorbic_acid	33,46	Cd2	100,103	ascorbic acid	Cd2	MESH:D001205	914	Chemical	Gene	START_ENTITY|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Protective effects of exogenous ascorbic_acid on antioxidant system in Hydrilla verticillata under Cd2 + -RSB- .
9821209	0	ascorbic_acid	27,40	Cholecystokinin	0,15	ascorbic acid	Cholecystokinin	MESH:D001205	25298(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|stimulates stimulates|compound|END_ENTITY	Cholecystokinin stimulates ascorbic_acid secretion through its specific receptor in the perfused stomach of rats .
1355577	0	ascorbic_acid	26,39	D1_and_D2	57,66	ascorbic acid	D1 and D2	MESH:D001205	25802	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Stereospecific effects of ascorbic_acid and analogues on D1_and_D2 agonist binding .
11509682	0	ascorbic_acid	37,50	Erythropoietin	0,14	ascorbic acid	Erythropoietin	MESH:D001205	2056	Chemical	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Erythropoietin and iron : the role of ascorbic_acid .
23212659	0	ascorbic_acid	94,107	LRP1	126,130	ascorbic acid	LRP1	MESH:D001205	4035	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Exploration of effects of emodin in selected cancer cell lines : enhanced growth inhibition by ascorbic_acid and regulation of LRP1 and AR under hypoxia-like conditions .
17141323	0	ascorbic_acid	86,99	PCB	0,3	ascorbic acid	PCB	MESH:D001205	25104(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY enhances|parataxis|role enhances|nsubj|END_ENTITY	PCB -LRB- Aroclor_1254 -RRB- enhances oxidative damage in rat brain regions : protective role of ascorbic_acid .
6415327	0	ascorbic_acid	40,53	Renin	0,5	ascorbic acid	Renin	MESH:D001205	24715(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY release|amod|END_ENTITY	Renin release and lipid peroxidation by ascorbic_acid in the renin granule fraction of rat kidney cortex .
7389073	0	ascorbic_acid	20,33	SMA	108,111	ascorbic acid	SMA	MESH:D001205	6606	Chemical	Gene	START_ENTITY|nmod|parameters parameters|compound|END_ENTITY	Estimation of serum ascorbic_acid in patients and the effect of ascorbic_acid and its oxidation products on SMA 12/60 parameters .
23892041	0	ascorbic_acid	97,110	SPC-A-1	140,147	ascorbic acid	SPC-A-1	MESH:D001205	27032	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Enhancement of -LRB- - -RRB- - epigallocatechin-3-gallate and theaflavin-3-3 ' - digallate induced apoptosis by ascorbic_acid in human lung_adenocarcinoma SPC-A-1 cells and esophageal_carcinoma Eca-109 cells via MAPK pathways .
10409116	0	ascorbic_acid	93,106	ST2	70,73	ascorbic acid	ST2	MESH:D001205	17082(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl:relcl|induced	Characterization of osteoblastic differentiation of stromal cell line ST2 that is induced by ascorbic_acid .
12897061	0	ascorbic_acid	78,91	SVCT2	105,110	ascorbic acid	SVCT2	MESH:D001205	54338(Tax:10090)	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Impaired adrenal catecholamine system function in mice with deficiency of the ascorbic_acid transporter -LRB- SVCT2 -RRB- .
15921655	0	ascorbic_acid	43,56	SVCT2	72,77	ascorbic acid	SVCT2	MESH:D001205	9962	Chemical	Gene	transport|nmod|START_ENTITY mediated|nsubjpass|transport mediated|nmod|END_ENTITY	Chondrocyte transport and concentration of ascorbic_acid is mediated by SVCT2 .
20843809	0	ascorbic_acid	38,51	SVCT2	100,105	ascorbic acid	SVCT2	MESH:D001205	9962	Chemical	Gene	transporter-2|amod|START_ENTITY residues|nmod|transporter-2 regulators|nsubj|residues regulators|nmod|function function|nummod|END_ENTITY	Histidine residues in the Na + - coupled ascorbic_acid transporter-2 -LRB- SVCT2 -RRB- are central regulators of SVCT2 function , modulating pH sensitivity , transporter kinetics , Na + cooperativity , conformational stability , and subcellular localization .
20843809	0	ascorbic_acid	38,51	SVCT2	67,72	ascorbic acid	SVCT2	MESH:D001205	9962	Chemical	Gene	transporter-2|amod|START_ENTITY transporter-2|appos|END_ENTITY	Histidine residues in the Na + - coupled ascorbic_acid transporter-2 -LRB- SVCT2 -RRB- are central regulators of SVCT2 function , modulating pH sensitivity , transporter kinetics , Na + cooperativity , conformational stability , and subcellular localization .
22001929	0	ascorbic_acid	101,114	SVCT2	57,62	ascorbic acid	SVCT2	MESH:D001205	54338(Tax:10090)	Chemical	Gene	depletion|amod|START_ENTITY END_ENTITY|nmod|depletion	Differential regulation of the ascorbic_acid transporter SVCT2 during development and in response to ascorbic_acid depletion .
22001929	0	ascorbic_acid	31,44	SVCT2	57,62	ascorbic acid	SVCT2	MESH:D001205	54338(Tax:10090)	Chemical	Gene	transporter|amod|START_ENTITY regulation|nmod|transporter END_ENTITY|nsubj|regulation	Differential regulation of the ascorbic_acid transporter SVCT2 during development and in response to ascorbic_acid depletion .
22558179	0	ascorbic_acid	58,71	SVCT2	24,29	ascorbic acid	SVCT2	MESH:D001205	54338(Tax:10090)	Chemical	Gene	raises|dep|START_ENTITY raises|nsubj|expression expression|nmod|END_ENTITY	Increased expression of SVCT2 in a new mouse model raises ascorbic_acid in tissues and protects against paraquat-induced oxidative damage in lung .
9221835	0	ascorbic_acid	95,108	TGF-beta1	66,75	ascorbic acid	TGF-beta1	MESH:D001205	7040	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Renal cell regeneration following oxidant exposure : inhibition by TGF-beta1 and stimulation by ascorbic_acid .
20977580	0	ascorbic_acid	23,36	adiponectin	97,108	ascorbic acid	adiponectin	MESH:D001205	9370	Chemical	Gene	effects|nmod|START_ENTITY effects|acl|END_ENTITY	Synergistic effects of ascorbic_acid and thiazolidinedione on secretion of high molecular weight adiponectin from human adipocytes .
1784840	0	ascorbic_acid	33,46	arylsulfatase_B	14,29	ascorbic acid	arylsulfatase B	MESH:D001205	411	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of arylsulfatase_B by ascorbic_acid .
22551313	0	ascorbic_acid	22,35	catalase	83,91	ascorbic acid	catalase	MESH:D001205	847	Chemical	Gene	stress|amod|START_ENTITY resistance|nmod|stress mediated|nsubjpass|resistance mediated|nmod|activity activity|amod|END_ENTITY	Natural resistance to ascorbic_acid induced oxidative stress is mainly mediated by catalase activity in human cancer cells and catalase-silencing sensitizes to oxidative stress .
6192633	0	ascorbic_acid	60,73	catalase	14,22	ascorbic acid	catalase	MESH:D001205	847	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of catalase on the inactivation of tyrosinase by ascorbic_acid and by cysteine or glutathione .
7980465	0	ascorbic_acid	55,68	catalase	12,20	ascorbic acid	catalase	MESH:D001205	847	Chemical	Gene	inactivation|nmod|START_ENTITY inactivation|compound|END_ENTITY	Erythrocyte catalase inactivation -LRB- H2O2 production -RRB- by ascorbic_acid and glucose in the presence of aminotriazole : role of transition_metals and relevance to diabetes .
8667243	0	ascorbic_acid	118,131	catalase	172,180	ascorbic acid	catalase	MESH:D001205	847	Chemical	Gene	concentrations|nmod|START_ENTITY elicited|nmod|concentrations cells|acl|elicited killing|nmod|cells mediates|dobj|killing mediates|parataxis|END_ENTITY	Hydrogen_peroxide mediates the killing of U937 tumor cells elicited by pharmacologically attainable concentrations of ascorbic_acid : cell death prevention by extracellular catalase or catalase from cocultured erythrocytes or fibroblasts .
8765690	1	ascorbic_acid	103,116	catalase	212,220	ascorbic acid	catalase	MESH:D001205	24248(Tax:10116)	Chemical	Gene	copper-ions|amod|START_ENTITY copper-ions|amod|superoxide superoxide|amod|END_ENTITY	Kinetics and influence of ascorbic_acid , glutathione , dimethylsulfoxide , N-t-butyl-a-phenyl-nitrone , copper-ions and a copper complex , catalase , superoxide dismutase , hexobarbital and aniline .
6526599	0	ascorbic_acid	21,34	cholesterol_7_alpha-hydroxylase	38,69	ascorbic acid	cholesterol 7 alpha-hydroxylase	MESH:D001205	25428(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Influence of dietary ascorbic_acid on cholesterol_7_alpha-hydroxylase activity in the rat .
1849895	0	ascorbic_acid	12,25	cytochrome_b561	31,46	ascorbic acid	cytochrome b561	MESH:D001205	1534	Chemical	Gene	Reaction|nmod|START_ENTITY Reaction|nmod|END_ENTITY	Reaction of ascorbic_acid with cytochrome_b561 .
315864	0	ascorbic_acid	132,145	dopamine-beta-hydroxylase	10,35	ascorbic acid	dopamine-beta-hydroxylase	MESH:D001205	1621	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|inhibitor inhibitor|amod|END_ENTITY	Effect of dopamine-beta-hydroxylase inhibitor -LRB- disulfiram -RRB- on the response of adenohypophysis , serum ceruloplasmin and hypothalamic ascorbic_acid to estradiol treatment .
745653	0	ascorbic_acid	28,41	dopamine-beta-hydroxylase	54,79	ascorbic acid	dopamine-beta-hydroxylase	MESH:D001205	1621	Chemical	Gene	proteins|nmod|START_ENTITY Denaturation|nmod|proteins Denaturation|dep|effects effects|nmod|END_ENTITY	Denaturation of proteins by ascorbic_acid : effects on dopamine-beta-hydroxylase .
10354297	0	ascorbic_acid	12,25	erythropoietin	65,79	ascorbic acid	erythropoietin	MESH:D001205	2056	Chemical	Gene	START_ENTITY|nmod|therapy therapy|nmod|END_ENTITY	Intravenous ascorbic_acid as an adjuvant therapy for recombinant erythropoietin in hemodialysis patients with hyperferritinemia .
9070901	0	ascorbic_acid	33,46	insulin	82,89	ascorbic acid	insulin	MESH:D001205	100379579(Tax:10141)	Chemical	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	Studies on the essential role of ascorbic_acid in the energy dependent release of insulin from pancreatic islets .
17956465	0	ascorbic_acid	55,68	interleukin-11	21,35	ascorbic acid	interleukin-11	MESH:D001205	3589	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Osteogenic effect of interleukin-11 and synergism with ascorbic_acid in human periodontal ligament cells .
825983	0	ascorbic_acid	14,27	lipoprotein_lipase	47,65	ascorbic acid	lipoprotein lipase	MESH:D001205	100126663(Tax:9555)	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	The effect of ascorbic_acid on the activity of lipoprotein_lipase in the baboon -LRB- Papio ursinus -RRB- .
10737223	0	ascorbic_acid	11,24	lipoxygenase	75,87	ascorbic acid	lipoxygenase	MESH:D001205	547836(Tax:3847)	Chemical	Gene	Effects|nmod|START_ENTITY membranes|nsubj|Effects membranes|nmod|END_ENTITY	Effects of ascorbic_acid on peroxidation of human erythrocyte membranes by lipoxygenase .
3089829	0	ascorbic_acid	38,51	lipoxygenase	22,34	ascorbic acid	lipoxygenase	MESH:D001205	100009114(Tax:9986)	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|END_ENTITY	Modulation of corneal lipoxygenase by ascorbic_acid .
2156823	0	ascorbic_acid	71,84	myeloperoxidase	50,65	ascorbic acid	myeloperoxidase	MESH:D001205	4353	Chemical	Gene	studies|nmod|START_ENTITY studies|nmod|END_ENTITY	Kinetic studies on the reaction of compound II of myeloperoxidase with ascorbic_acid .
2156842	0	ascorbic_acid	49,62	myeloperoxidase	28,43	ascorbic acid	myeloperoxidase	MESH:D001205	511206(Tax:9913)	Chemical	Gene	Reaction|nmod|START_ENTITY Reaction|nmod|END_ENTITY	Reaction of compound III of myeloperoxidase with ascorbic_acid .
8445988	0	ascorbic_acid	10,23	prolactin	37,46	ascorbic acid	prolactin	MESH:D001205	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Effect of ascorbic_acid on pituitary prolactin secretion in the non-ascorbate synthesizing Osteogenic_Disorder Shionogi -LRB- ODS -RRB- rat .
14679398	0	ascorbic_acid_2-glucoside	48,73	Annexin_V	0,9	ascorbic acid 2-glucoside	Annexin V	MESH:C065378	25673(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|compound|END_ENTITY	Annexin_V assay-proven anti-apoptotic effect of ascorbic_acid_2-glucoside after cold_ischemia / reperfusion injury in rat liver transplantation .
10484072	0	ascorbigen	45,55	cytochrome_P4501A1	14,32	ascorbigen	cytochrome P4501A1	MESH:C053152	13076(Tax:10090)	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|activity activity|amod|END_ENTITY	Modulation of cytochrome_P4501A1 activity by ascorbigen in murine hepatoma cells .
25960006	0	asenapine	19,28	FosB	42,46	asenapine	FosB	MESH:C522667	100360880	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|expression expression|compound|END_ENTITY	Impact of repeated asenapine treatment on FosB / FosB expression in neurons of the rat central nucleus of the amygdala : colocalization with corticoliberine -LRB- CRH -RRB- and effect of an unpredictable mild stress preconditioning .
25960006	0	asenapine	19,28	FosB	49,53	asenapine	FosB	MESH:C522667	100360880	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|expression expression|compound|END_ENTITY	Impact of repeated asenapine treatment on FosB / FosB expression in neurons of the rat central nucleus of the amygdala : colocalization with corticoliberine -LRB- CRH -RRB- and effect of an unpredictable mild stress preconditioning .
18279797	0	asiatic_acid	52,64	NF-kappa_B	69,79	asiatic acid	NF-kappa B	MESH:C017032	18033(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|inactivation inactivation|amod|END_ENTITY	Inhibition of LPS-induced NO and PGE2 production by asiatic_acid via NF-kappa_B inactivation in RAW 264.7 macrophages : possible involvement of the IKK and MAPK pathways .
21349323	0	asiaticoside	31,43	cytochrome_P450	71,86	asiaticoside	cytochrome P450	MESH:C004446	4051	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	In vitro inhibitory effects of asiaticoside and madecassoside on human cytochrome_P450 .
22972613	0	asiaticoside	45,57	heme_oxygenase-1	117,133	asiaticoside	heme oxygenase-1	MESH:C004446	24451(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Antipyretic and anti-inflammatory effects of asiaticoside in lipopolysaccharide-treated rat through up-regulation of heme_oxygenase-1 .
10971307	0	asimadoline	13,24	kappa-opioid_receptor	32,53	asimadoline	kappa-opioid receptor	MESH:C092095	4986	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Influence of asimadoline , a new kappa-opioid_receptor agonist , on tubular water absorption and vasopressin secretion in man .
16613890	0	asoprisnil	50,60	EGF	101,104	asoprisnil	EGF	MESH:C488516	1950	Chemical	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|nmod|END_ENTITY	A novel selective progesterone receptor modulator asoprisnil -LRB- J867 -RRB- down-regulates the expression of EGF , IGF-I , TGFbeta3 and their receptors in cultured uterine leiomyoma cells .
15714390	0	asoprisnil	55,65	progesterone_receptor	120,141	asoprisnil	progesterone receptor	MESH:C488516	100724945	Chemical	Gene	modulators|amod|START_ENTITY modulators|compound|END_ENTITY	Discovery , chemistry , and reproductive pharmacology of asoprisnil and related_11beta-benzaldoxime substituted selective progesterone_receptor modulators -LRB- SPRMs -RRB- .
24261664	0	aspalathin	64,74	Xanthine_oxidase	0,16	aspalathin	Xanthine oxidase	MESH:C517016	22436(Tax:10090)	Chemical	Gene	activity|nmod|START_ENTITY END_ENTITY|dobj|activity	Xanthine_oxidase inhibitory activity and hypouricemic effect of aspalathin from unfermented rooibos .
9169089	0	asparagine	17,27	Myc	51,54	asparagine	Myc	CHEBI:17196	4609	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Highly conserved asparagine in the basic domain of Myc is dispensable for DNA binding , transformation , and apoptosis .
12031600	0	asparagine	16,26	apolipoprotein_B	68,84	asparagine	apolipoprotein B	CHEBI:17196	338	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of an asparagine to lysine mutation at amino_acid 3516 of apolipoprotein_B on low-density_lipoprotein_receptor binding .
17566603	0	asparagine	106,116	glutamate_dehydrogenase	20,43	asparagine	glutamate dehydrogenase	CHEBI:17196	2746	Chemical	Gene	role|acl|START_ENTITY role|nmod|END_ENTITY	The pivotal role of glutamate_dehydrogenase -LRB- GDH -RRB- in the mobilization of N and C from storage material to asparagine in germinating seeds of yellow lupine .
12031600	0	asparagine	16,26	low-density_lipoprotein_receptor	88,120	asparagine	low-density lipoprotein receptor	CHEBI:17196	3949	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of an asparagine to lysine mutation at amino_acid 3516 of apolipoprotein_B on low-density_lipoprotein_receptor binding .
10070056	0	asparagine	15,25	ornithine_decarboxylase	55,78	asparagine	ornithine decarboxylase	CHEBI:17196	24609(Tax:10116)	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|regulation regulation|nmod|END_ENTITY	Interaction of asparagine and EGF in the regulation of ornithine_decarboxylase in IEC-6 cells .
1551904	0	asparagine	70,80	ornithine_decarboxylase	27,50	asparagine	ornithine decarboxylase	CHEBI:17196	18263(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Mechanism of regulation of ornithine_decarboxylase gene expression by asparagine in a variant mouse neuroblastoma cell line .
1952937	0	asparagine	62,72	ornithine_decarboxylase	35,58	asparagine	ornithine decarboxylase	CHEBI:17196	4953	Chemical	Gene	mechanism|nmod|START_ENTITY mechanism|nmod|END_ENTITY	Translational control mechanism of ornithine_decarboxylase by asparagine and putrescine in primary cultured hepatocytes .
8439991	0	asparagine	23,33	ornithine_decarboxylase	83,106	asparagine	ornithine decarboxylase	CHEBI:17196	24609(Tax:10116)	Chemical	Gene	levels|amod|START_ENTITY actions|nmod|levels +|nsubj|actions +|nmod|induction induction|nmod|END_ENTITY	Independent actions of asparagine and high levels of free Ca2 + in the induction of ornithine_decarboxylase .
8760120	0	asparagine	62,72	ornithine_decarboxylase	18,41	asparagine	ornithine decarboxylase	CHEBI:17196	24609(Tax:10116)	Chemical	Gene	Expression|acl|START_ENTITY Expression|nmod|gene gene|amod|END_ENTITY	Expression of the ornithine_decarboxylase gene in response to asparagine in intestinal epithelial cells .
21730057	0	asparagine	12,22	serotonin_transporter	67,88	asparagine	serotonin transporter	CHEBI:17196	6532	Chemical	Gene	residue|compound|START_ENTITY residue|nmod|END_ENTITY	A conserved asparagine residue in transmembrane segment 1 -LRB- TM1 -RRB- of serotonin_transporter dictates chloride-coupled neurotransmitter transport .
12215170	0	asparaginyl	25,36	FIH-1	50,55	asparaginyl	FIH-1	CHEBI:22656	55662	Chemical	Gene	hydroxylase|compound|START_ENTITY hydroxylase|appos|END_ENTITY	Hypoxia-inducible factor asparaginyl hydroxylase -LRB- FIH-1 -RRB- catalyses hydroxylation at the beta-carbon of asparagine-803 .
16129618	0	aspartame	14,23	acetylcholinesterase	66,86	aspartame	acetylcholinesterase	MESH:D001218	43	Chemical	Gene	metabolites|compound|START_ENTITY effect|nmod|metabolites END_ENTITY|nsubj|effect	The effect of aspartame metabolites on human erythrocyte membrane acetylcholinesterase activity .
17580119	0	aspartame	14,23	acetylcholinesterase	27,47	aspartame	acetylcholinesterase	MESH:D001218	83817(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|amod|END_ENTITY	The effect of aspartame on acetylcholinesterase activity in hippocampal homogenates of suckling rats .
17673349	0	aspartame	14,23	acetylcholinesterase	71,91	aspartame	acetylcholinesterase	MESH:D001218	83817(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY metabolites|nsubj|effect metabolites|nmod|END_ENTITY	The effect of aspartame metabolites on the suckling rat frontal cortex acetylcholinesterase .
11890951	0	aspartame	34,43	neuropeptide_Y	60,74	aspartame	neuropeptide Y	MESH:D001218	24604(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of long-term ingestion of aspartame on hypothalamic neuropeptide_Y , plasma leptin and body weight_gain and composition .
12802606	0	aspartate	8,17	ALP56	33,38	aspartate	ALP56	CHEBI:29995	25825	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel aspartate protease gene , ALP56 , is related to morphological features of colorectal_adenomas .
10802344	0	aspartate	21,30	BDNF	0,4	aspartate	BDNF	CHEBI:29995	627	Chemical	Gene	release|amod|START_ENTITY induces|dobj|release induces|nsubj|END_ENTITY	BDNF rapidly induces aspartate release from cultured CNS neurons .
16032772	0	aspartate	9,18	FET3	31,35	aspartate	FET3	CHEBI:29995	855080(Tax:4932)	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	Specific aspartate residues in FET3 control high-affinity iron transport in Saccharomyces_cerevisiae .
9099897	0	aspartate	38,47	Prolactin	0,9	aspartate	Prolactin	CHEBI:29995	5617	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|compound|END_ENTITY	Prolactin regulation of mitochondrial aspartate aminotransferase and protein_kinase_C in human prostate_cancer cells .
11739897	0	aspartate	9,18	alpha-lactalbumin	50,67	aspartate	alpha-lactalbumin	CHEBI:29995	281894(Tax:9913)	Chemical	Gene	START_ENTITY|nmod|site site|nmod|END_ENTITY	Mutating aspartate in the calcium-binding site of alpha-lactalbumin : effects on the protein stability and cation binding .
7849073	0	aspartate	29,38	glucose_oxidase	10,25	aspartate	glucose oxidase	CHEBI:29995	54363	Chemical	Gene	residues|amod|START_ENTITY END_ENTITY|nmod|residues	Targeting glucose_oxidase at aspartate and glutamate residues with organic two-electron redox mediators .
1672477	0	aspartate	59,68	growth_hormone	110,124	aspartate	growth hormone	CHEBI:29995	81668(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|acl|circulating circulating|dobj|END_ENTITY	Sex - and dose-dependent effects of neonatally administered aspartate on the ultradian patterns of circulating growth_hormone regulating hexobarbital metabolism and action .
9351900	0	aspartate	56,65	growth_hormone	99,113	aspartate	growth hormone	CHEBI:29995	81668(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nsubj|effects	Gender , age and dose effects of neonatally administered aspartate on the sexually dimorphic plasma growth_hormone profiles regulating expression of the rat sex-dependent hepatic CYP isoforms .
21491491	0	aspartate	89,98	phosphoenolpyruvate_carboxylase	30,61	aspartate	phosphoenolpyruvate carboxylase	CHEBI:29995	100101511(Tax:4577)	Chemical	Gene	inhibition|nmod|START_ENTITY sensitive|xcomp|inhibition END_ENTITY|xcomp|sensitive	Structure of an archaeal-type phosphoenolpyruvate_carboxylase sensitive to inhibition by aspartate .
24414875	0	aspartate	73,82	phosphoenolpyruvate_carboxylase	26,57	aspartate	phosphoenolpyruvate carboxylase	CHEBI:29995	5105	Chemical	Gene	Protection|nmod|START_ENTITY inactivation|dep|Protection inactivation|nmod|END_ENTITY	Heat inactivation of leaf phosphoenolpyruvate_carboxylase : Protection by aspartate and malate in C4 plants .
4093449	0	aspartate	61,70	phosphoenolpyruvate_carboxylase	26,57	aspartate	phosphoenolpyruvate carboxylase	CHEBI:29995	5105	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Synergistic inhibition of phosphoenolpyruvate_carboxylase by aspartate and 2-oxoglutarate in Brevibacterium flavum .
12111366	0	aspartate_glutamate	14,33	citrin	43,49	aspartate glutamate	citrin	null	10165	Chemical	Gene	carrier|compound|START_ENTITY carrier|appos|END_ENTITY	Mitochondrial aspartate_glutamate carrier -LRB- citrin -RRB- deficiency as the cause of adult-onset type_II_citrullinemia -LRB- CTLN2 -RRB- and idiopathic_neonatal_hepatitis -LRB- NICCD -RRB- .
14622120	0	aspartic_acid	36,49	ASCT2	65,70	aspartic acid	ASCT2	CHEBI:22660	20514(Tax:10090)	Chemical	Gene	transport|nmod|START_ENTITY mediated|nsubjpass|transport mediated|nmod|END_ENTITY	The l-isomer-selective transport of aspartic_acid is mediated by ASCT2 at the blood-brain barrier .
11090274	0	aspartic_acid	3,16	TPR-1	28,33	aspartic acid	TPR-1	CHEBI:22660	7265	Chemical	Gene	residue|amod|START_ENTITY residue|nmod|END_ENTITY	An aspartic_acid residue in TPR-1 , a specific region of protein-priming DNA polymerases , is required for the functional interaction with primer terminal protein .
11325591	0	aspartic_acid	133,146	granzyme_B	41,51	aspartic acid	granzyme B	CHEBI:22660	3002	Chemical	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	The three-dimensional structure of human granzyme_B compared to caspase-3 , key mediators of cell death with cleavage specificity for aspartic_acid in P1 .
9091313	0	aspartic_acid	28,41	hormone-sensitive_lipase	68,92	aspartic acid	hormone-sensitive lipase	CHEBI:22660	3991	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Identification of essential aspartic_acid and histidine residues of hormone-sensitive_lipase : apparent residues of the catalytic triad .
15527797	0	aspartic_acid	32,45	neuraminidase	76,89	aspartic acid	neuraminidase	CHEBI:22660	4758	Chemical	Gene	START_ENTITY|nmod|catalysis catalysis|nmod|END_ENTITY	Contribution of the active site aspartic_acid to catalysis in the bacterial neuraminidase from Micromonospora viridifaciens .
9461487	0	aspartic_acid	19,32	transferrin	56,67	aspartic acid	transferrin	CHEBI:22660	7018	Chemical	Gene	ligands|amod|START_ENTITY ligands|nmod|END_ENTITY	Mutagenesis of the aspartic_acid ligands in human serum transferrin : lobe-lobe interaction and conformation as revealed by antibody , receptor-binding and iron-release studies .
25587118	0	aspartyl	32,40	ClC-5	17,22	aspartyl	ClC-5	null	25749(Tax:10116)	Chemical	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	Chloride channel ClC-5 binds to aspartyl aminopeptidase to regulate renal albumin endocytosis .
25164821	0	aspartyl	93,101	Dnpep	118,123	aspartyl	Dnpep	null	23549	Chemical	Gene	aminopeptidase|amod|START_ENTITY aminopeptidase|appos|END_ENTITY	Short forms of Ste20-related_proline / alanine-rich_kinase -LRB- SPAK -RRB- in the kidney are created by aspartyl aminopeptidase -LRB- Dnpep -RRB- - mediated proteolytic cleavage .
15585673	0	aspartyl	79,87	proteinase	88,98	aspartyl	proteinase	null	100616101	Chemical	Gene	resistance|amod|START_ENTITY resistance|compound|END_ENTITY	IL-8 / CXC_ligand_8 survives neonatal gastric digestion as a result of intrinsic aspartyl proteinase resistance .
20674352	0	aspartyl_acyloxyalkyl_ketones	72,101	ICE_or_caspase_1	51,67	aspartyl acyloxyalkyl ketones	ICE or caspase 1	null	834	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of interleukin-1beta_converting_enzyme -LRB- ICE_or_caspase_1 -RRB- by aspartyl_acyloxyalkyl_ketones and aspartyl_amidooxyalkyl_ketones .
20674352	0	aspartyl_acyloxyalkyl_ketones	72,101	interleukin-1beta_converting_enzyme	14,49	aspartyl acyloxyalkyl ketones	interleukin-1beta converting enzyme	null	834	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of interleukin-1beta_converting_enzyme -LRB- ICE_or_caspase_1 -RRB- by aspartyl_acyloxyalkyl_ketones and aspartyl_amidooxyalkyl_ketones .
14741294	0	aspartyl_ketone_dipeptides	19,45	caspase-3	70,79	aspartyl ketone dipeptides	caspase-3	null	836	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Discovery of novel aspartyl_ketone_dipeptides as potent and selective caspase-3 inhibitors .
20378968	0	aspernolide_A	74,87	lipoxygenase	8,20	aspernolide A	lipoxygenase	MESH:C540299	547836(Tax:3847)	Chemical	Gene	activities|nmod|START_ENTITY END_ENTITY|dobj|activities	Soybean lipoxygenase inhibitory and DPPH radical-scavenging activities of aspernolide_A and butyrolactones_I_and_II .
12692751	0	aspirin	23,30	ACE	36,39	aspirin	ACE	MESH:D001241	24310(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|compound|END_ENTITY	Comparative effects of aspirin with ACE inhibitor or angiotensin receptor blocker on myocardial_infarction and vascular function .
9334204	0	aspirin	75,82	AP-1	57,61	aspirin	AP-1	MESH:D001241	16476(Tax:10090)	Chemical	Gene	activity|nmod|START_ENTITY activity|appos|END_ENTITY	Inhibition of ultraviolet B-induced activator_protein-1 -LRB- AP-1 -RRB- activity by aspirin in AP-1-luciferase transgenic_mice .
9472093	0	aspirin	65,72	AP-1	48,52	aspirin	AP-1	MESH:D001241	3725	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activity activity|compound|END_ENTITY	Inhibition of ultraviolet C irradiation-induced AP-1 activity by aspirin is through inhibition of JNKs but not erks or P38_MAP_kinase .
10590187	0	aspirin	21,28	C-reactive_protein	36,54	aspirin	C-reactive protein	MESH:D001241	1401	Chemical	Gene	Effect|nmod|START_ENTITY use|nsubj|Effect use|nmod|END_ENTITY	Effect of short-term aspirin use on C-reactive_protein .
11300433	0	aspirin	14,21	C-reactive_protein	25,43	aspirin	C-reactive protein	MESH:D001241	1401	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of aspirin on C-reactive_protein as a marker of risk in unstable_angina .
11419884	0	aspirin	20,27	C-reactive_protein	143,161	aspirin	C-reactive protein	MESH:D001241	1401	Chemical	Gene	Effects|nmod|START_ENTITY Effects|dep|study study|acl|using using|dobj|assay assay|amod|END_ENTITY	Effects of low-dose aspirin on serum C-reactive_protein and thromboxane_B2 concentrations : a placebo-controlled study using a highly sensitive C-reactive_protein assay .
16607074	0	aspirin	43,50	C-reactive_protein	76,94	aspirin	C-reactive protein	MESH:D001241	1401	Chemical	Gene	Lack|nmod|START_ENTITY Lack|nmod|END_ENTITY	Lack of significant effect of low doses of aspirin on the concentrations of C-reactive_protein in a group of individuals with atherothrombotic risk factors and vascular events .
18585504	0	aspirin	43,50	C-reactive_protein	71,89	aspirin	C-reactive protein	MESH:D001241	1401	Chemical	Gene	associations|nmod|START_ENTITY assessment|nmod|associations use|nsubj|assessment use|nmod|concentration concentration|amod|END_ENTITY	An assessment of the joint associations of aspirin and statin use with C-reactive_protein concentration .
21166598	0	aspirin	14,21	C-reactive_protein	25,43	aspirin	C-reactive protein	MESH:D001241	1401	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of aspirin on C-reactive_protein in hypertensive patients .
12615789	0	aspirin	60,67	CD40	94,98	aspirin	CD40	MESH:D001241	958	Chemical	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	Inhibitory effects of glycoprotein IIb/IIIa antagonists and aspirin on the release of soluble CD40 ligand during platelet stimulation .
11577463	0	aspirin	46,53	COX-1	62,67	aspirin	COX-1	MESH:D001241	4512	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	-LSB- Cyclooxygenase -LRB- COX -RRB- -2 selective inhibitors : aspirin , a dual COX-1 / COX-2 inhibitor , to COX-2 selective inhibitors -RSB- .
17191809	7	aspirin	1279,1286	COX-1	1135,1140	aspirin	COX-1	MESH:D001241	5742	Chemical	Gene	drug|appos|START_ENTITY those|nmod|drug comparable|nmod|those values|xcomp|comparable values|advcl|inactive inactive|nmod|cyclooxygenase_1 cyclooxygenase_1|appos|END_ENTITY	While bauhinol_A -LRB- 1 -RRB- is inactive against cyclooxygenase_1 -LRB- COX-1 -RRB- and cyclooxygenase_2 -LRB- COX-2 -RRB- , compounds 2 and 6 inhibit both COX-1 and COX-2 , with IC50 values comparable to those of the standard drug , aspirin -LRB- Table 3 -RRB- .
17549313	0	aspirin	90,97	COX-1	81,86	aspirin	COX-1	MESH:D001241	4512	Chemical	Gene	blunts|nmod|START_ENTITY blunts|dobj|inhibition inhibition|nmod|END_ENTITY	Gallic_acid , a dietary polyphenolic component , blunts the inhibition of platelet COX-1 by aspirin : preliminary in-vitro findings .
17631383	0	aspirin	36,43	COX-1	62,67	aspirin	COX-1	MESH:D001241	4512	Chemical	Gene	responsiveness|nmod|START_ENTITY independent|nsubj|responsiveness independent|nmod|levels levels|amod|END_ENTITY	Platelet responsiveness to in vitro aspirin is independent of COX-1 and COX-2 protein levels and polymorphisms .
19346231	0	aspirin	101,108	COX-1	0,5	aspirin	COX-1	MESH:D001241	4512	Chemical	Gene	treatment|compound|START_ENTITY sensitivity|nmod|treatment sensitivity|compound|END_ENTITY	COX-1 sensitivity and thromboxane_A2 production in type 1 and type 2 diabetic patients under chronic aspirin treatment .
20404564	0	aspirin	84,91	COX-1	101,106	aspirin	COX-1	MESH:D001241	5742	Chemical	Gene	START_ENTITY|nmod|cells cells|amod|positive positive|amod|END_ENTITY	The effects of the histone deacetylase inhibitor romidepsin -LRB- FK228 -RRB- are enhanced by aspirin -LRB- ASA -RRB- in COX-1 positive ovarian_cancer cells through augmentation of p21 .
23422285	8	aspirin	1129,1136	COX-1	1090,1095	aspirin	COX-1	MESH:D001241	5742	Chemical	Gene	treatment|compound|START_ENTITY detected|nmod|treatment detected|nsubjpass|END_ENTITY	RESULTS : No acetylated COX-1 was detected in platelets before aspirin treatment .
24244288	0	aspirin	106,113	COX-1	72,77	aspirin	COX-1	MESH:D001241	4512	Chemical	Gene	insensitivity|compound|START_ENTITY genes|nmod|insensitivity genes|appos|END_ENTITY	The association of four common polymorphisms from four candidate genes -LRB- COX-1 , COX-2 , ITGA2B , ITGA2 -RRB- with aspirin insensitivity : a meta-analysis .
25307725	0	aspirin	29,36	COX-1	58,63	aspirin	COX-1	MESH:D001241	4512	Chemical	Gene	START_ENTITY|nmod|binding binding|compound|END_ENTITY	Competition between low-dose aspirin and other NSAIDs for COX-1 binding and its clinical consequences for the drugs ' antiplatelet effects .
10639016	2	aspirin	252,259	COX-2	364,369	aspirin	COX-2	MESH:D001241	4513	Chemical	Gene	inhibitor|nsubj|START_ENTITY suggested|advcl|inhibitor suggested|ccomp|play play|nsubj|END_ENTITY	Since aspirin is a weak inhibitor of the inducible isoform of prostaglandin_H synthase -LRB- COX-2 -RRB- , it was suggested that COX-2 may play a role in aspirin resistance .
10639016	2	aspirin	389,396	COX-2	364,369	aspirin	COX-2	MESH:D001241	4513	Chemical	Gene	resistance|compound|START_ENTITY role|nmod|resistance play|dobj|role play|nsubj|END_ENTITY	Since aspirin is a weak inhibitor of the inducible isoform of prostaglandin_H synthase -LRB- COX-2 -RRB- , it was suggested that COX-2 may play a role in aspirin resistance .
10639016	6	aspirin	1139,1146	COX-2	1234,1239	aspirin	COX-2	MESH:D001241	4513	Chemical	Gene	suppressed|nsubj|START_ENTITY suppressed|advcl|affecting affecting|dobj|activity activity|compound|END_ENTITY	In contrast , aspirin -LRB- 55 micromol/L -RRB- largely suppressed platelet TXB2 production without affecting monocyte COX-2 activity .
11464731	0	aspirin	27,34	COX-2	38,43	aspirin	COX-2	MESH:D001241	5743	Chemical	Gene	Understanding|nmod|START_ENTITY Understanding|nmod|END_ENTITY	Understanding NSAIDs : from aspirin to COX-2 .
11577463	0	aspirin	46,53	COX-2	68,73	aspirin	COX-2	MESH:D001241	4513	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	-LSB- Cyclooxygenase -LRB- COX -RRB- -2 selective inhibitors : aspirin , a dual COX-1 / COX-2 inhibitor , to COX-2 selective inhibitors -RSB- .
11577463	0	aspirin	46,53	COX-2	88,93	aspirin	COX-2	MESH:D001241	4513	Chemical	Gene	Cyclooxygenase|dep|START_ENTITY Cyclooxygenase|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Cyclooxygenase -LRB- COX -RRB- -2 selective inhibitors : aspirin , a dual COX-1 / COX-2 inhibitor , to COX-2 selective inhibitors -RSB- .
11695246	8	aspirin	1618,1625	COX-2	1515,1520	aspirin	COX-2	MESH:D001241	4513	Chemical	Gene	receiving|dobj|START_ENTITY patients|acl|receiving used|nmod|patients safer|ccomp|used safer|nsubj|inhibitors inhibitors|amod|selective selective|amod|END_ENTITY	Further studies are needed to determine whether COX-2 selective inhibitors are safer than nonselective NSAIDs when used in patients receiving low-dose aspirin .
14519044	0	aspirin	51,58	COX-2	10,15	aspirin	COX-2	MESH:D001241	5743	Chemical	Gene	hypersensitivity|compound|START_ENTITY inhibitors|nmod|hypersensitivity inhibitors|nsubj|Safety Safety|nmod|END_ENTITY	Safety of COX-2 inhibitors in asthma patients with aspirin hypersensitivity .
16175430	0	aspirin	46,53	COX-2	57,62	aspirin	COX-2	MESH:D001241	5743	Chemical	Gene	addition|nmod|START_ENTITY effects|nmod|addition effects|nmod|drugs drugs|compound|END_ENTITY	The renal effects of the addition of low-dose aspirin to COX-2 selective and nonselective antiinflammatory drugs .
16804302	0	aspirin	24,31	COX-2	44,49	aspirin	COX-2	MESH:D001241	26198(Tax:10116)	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	Oral but not parenteral aspirin upregulates COX-2 expression in rat stomachs .
18156036	0	aspirin	150,157	COX-2	4,9	aspirin	COX-2	MESH:D001241	4513	Chemical	Gene	taking|dobj|START_ENTITY cardiovascular_events|acl|taking risk|nmod|cardiovascular_events patients|nmod|risk drugs|nmod|patients preferable|nmod|drugs preferable|nsubj|inhibitors inhibitors|compound|END_ENTITY	Are COX-2 inhibitors preferable to non-selective non-steroidal anti-inflammatory drugs in patients with risk of cardiovascular_events taking low-dose aspirin ?
19938885	0	aspirin	9,16	COX-2	57,62	aspirin	COX-2	MESH:D001241	4513	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|properties properties|nmod|inhibitors inhibitors|amod|selective selective|amod|END_ENTITY	Low-dose aspirin reduces gastro-protective properties of COX-2 selective inhibitors .
23240010	0	aspirin	130,137	COX-2	66,71	aspirin	COX-2	MESH:D001241	5743	Chemical	Gene	intolerance|compound|START_ENTITY regulating|nmod|intolerance regulating|dobj|expression expression|compound|END_ENTITY	Signal transduction pathways -LRB- MAPKs , NF-kB , and C/EBP -RRB- regulating COX-2 expression in nasal fibroblasts from asthma patients with aspirin intolerance .
24244288	0	aspirin	106,113	COX-2	79,84	aspirin	COX-2	MESH:D001241	4513	Chemical	Gene	insensitivity|compound|START_ENTITY genes|nmod|insensitivity genes|appos|COX-1 COX-1|dep|END_ENTITY	The association of four common polymorphisms from four candidate genes -LRB- COX-1 , COX-2 , ITGA2B , ITGA2 -RRB- with aspirin insensitivity : a meta-analysis .
9726391	0	aspirin	148,155	COX-2	113,118	aspirin	COX-2	MESH:D001241	26198(Tax:10116)	Chemical	Gene	damage|compound|START_ENTITY END_ENTITY|nmod|damage	Activation of genes for spasmolytic peptide , transforming_growth_factor_alpha and for cyclooxygenase _ -LRB- COX -RRB- -1 and COX-2 during gastric adaptation to aspirin damage in rats .
24576527	0	aspirin	73,80	CYP2C19	14,21	aspirin	CYP2C19	MESH:D001241	1557	Chemical	Gene	Prevalence|nmod|START_ENTITY Prevalence|nmod|alleles alleles|nummod|END_ENTITY	Prevalence of CYP2C19 variant alleles and pharmacodynamic variability of aspirin and clopidogrel in Native Americans .
23493387	0	aspirin	64,71	EP3	23,26	aspirin	EP3	MESH:D001241	5733	Chemical	Gene	effect|nmod|START_ENTITY mediates|dobj|effect mediates|nsubj|END_ENTITY	Prostaglandin receptor EP3 mediates growth inhibitory effect of aspirin through androgen receptor and contributes to castration resistance in prostate_cancer cells .
24026640	0	aspirin	11,18	ERK	26,29	aspirin	ERK	MESH:D001241	24338(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|signaling signaling|compound|END_ENTITY	Effects of aspirin on the ERK and PI3K/Akt signaling pathways in rats with acute_pulmonary_embolism .
11046058	0	aspirin	67,74	IL-1_beta_converting_enzyme	0,27	aspirin	IL-1 beta converting enzyme	MESH:D001241	834	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	IL-1_beta_converting_enzyme is a target for nitric_oxide-releasing aspirin : new insights in the antiinflammatory mechanism of nitric_oxide-releasing nonsteroidal antiinflammatory drugs .
3926716	2	aspirin	48,55	IL-2	87,91	aspirin	IL-2	MESH:D001241	3558	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|production production|compound|END_ENTITY	Effects of aspirin and thymosin on enhancement of IL-2 production .
24244288	0	aspirin	106,113	ITGA2	94,99	aspirin	ITGA2	MESH:D001241	3673	Chemical	Gene	insensitivity|compound|START_ENTITY genes|nmod|insensitivity genes|appos|COX-1 COX-1|dep|END_ENTITY	The association of four common polymorphisms from four candidate genes -LRB- COX-1 , COX-2 , ITGA2B , ITGA2 -RRB- with aspirin insensitivity : a meta-analysis .
23126503	0	aspirin	31,38	LOX-1	94,99	aspirin	LOX-1	MESH:D001241	4973	Chemical	Gene	complex|compound|START_ENTITY complex|nmod|site site|nmod|END_ENTITY	Comparative binding effects of aspirin and anti-inflammatory Cu complex in the active site of LOX-1 .
20407607	0	aspirin	84,91	MMP-2	62,67	aspirin	MMP-2	MESH:D001241	81686(Tax:10116)	Chemical	Gene	using|dobj|START_ENTITY Attenuation|acl|using Attenuation|nmod|diabetic_retinopathy diabetic_retinopathy|nmod|inhibition inhibition|nmod|END_ENTITY	Attenuation of diabetic_retinopathy by enhanced inhibition of MMP-2 and MMP-9 using aspirin and minocycline in streptozotocin-diabetic rats .
21655062	0	aspirin	10,17	NF-kB	50,55	aspirin	NF-kB	MESH:D001241	81736(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	Effect of aspirin on the expression of hepatocyte NF-kB and serum TNF-a in streptozotocin-induced type 2 diabetic rats .
10698490	0	aspirin	89,96	NF-kappaB	50,59	aspirin	NF-kappaB	MESH:D001241	4790	Chemical	Gene	inhibits|nmod|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Overexpression of the wild-type p53 gene inhibits NF-kappaB activity and synergizes with aspirin to induce apoptosis in human colon_cancer cells .
17644113	0	aspirin	56,63	NF-kappaB	74,83	aspirin	NF-kappaB	MESH:D001241	4790	Chemical	Gene	apoptosis|nmod|START_ENTITY Prevention|nmod|apoptosis Prevention|dep|roles roles|nmod|signaling signaling|compound|END_ENTITY	Prevention of deoxycholate-induced gastric apoptosis by aspirin : roles of NF-kappaB and PKC signaling .
18174252	0	aspirin	12,19	NF-kappaB	47,56	aspirin	NF-kappaB	MESH:D001241	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	NO-donating aspirin inhibits the activation of NF-kappaB in human cancer cell lines and Min mice .
15188000	0	aspirin	51,58	NF_kappa_B	70,80	aspirin	NF kappa B	MESH:D001241	4790	Chemical	Gene	effects|compound|START_ENTITY effects|nmod|END_ENTITY	Evidence for colorectal_cancer cell specificity of aspirin effects on NF_kappa_B signalling and apoptosis .
17995973	0	aspirin	48,55	P2Y12	0,5	aspirin	P2Y12	MESH:D001241	64805	Chemical	Gene	polymorphisms|nmod|START_ENTITY polymorphisms|nummod|END_ENTITY	P2Y12 polymorphisms and antiplatelet effects of aspirin in patients with coronary_artery_disease .
24309957	0	aspirin	10,17	P2Y12	43,48	aspirin	P2Y12	MESH:D001241	64805	Chemical	Gene	Impact|nmod|START_ENTITY Impact|nmod|END_ENTITY	Impact of aspirin dosing on the effects of P2Y12 inhibition in patients with acute_coronary_syndromes .
12398900	6	aspirin	1158,1165	PGHS-1	1211,1217	aspirin	PGHS-2	MESH:D001241	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	This finding indicates that specific PGHS-2 inhibitors are similar to ibuprofen in their ability to compete with aspirin , an irreversible time-dependent inhibitor of PGHS-1 often used for prevention of spontaneous thrombosis .
9643753	0	aspirin	34,41	PlA2	0,4	aspirin	PlA2	MESH:D001241	5319	Chemical	Gene	polymorphism|nmod|START_ENTITY polymorphism|amod|END_ENTITY	PlA2 polymorphism and efficacy of aspirin .
19268942	0	aspirin	13,20	SR-BI	24,29	aspirin	SR-BI	MESH:D001241	949	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|expression expression|amod|END_ENTITY	Influence of aspirin on SR-BI expression in human carotid plaques .
16262603	0	aspirin	64,71	SSAT	55,59	aspirin	SSAT	MESH:D001241	6303	Chemical	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of spermidine/spermine _ N1-acetyltransferase -LRB- SSAT -RRB- by aspirin in Caco-2 colon_cancer cells .
19409619	0	aspirin	10,17	TNFalpha	31,39	aspirin	TNFalpha	MESH:D001241	7124	Chemical	Gene	treatment|compound|START_ENTITY Effect|nmod|treatment Effect|nmod|production production|compound|END_ENTITY	Effect of aspirin treatment on TNFalpha production by women with a history of preterm_birth .
17622933	0	aspirin	65,72	UGT1A6	0,6	aspirin	UGT1A6	MESH:D001241	54578	Chemical	Gene	polymorphism|nmod|START_ENTITY polymorphism|compound|END_ENTITY	UGT1A6 polymorphism and salicylic_acid glucuronidation following aspirin .
18544566	0	aspirin	12,19	VEGF	57,61	aspirin	VEGF	MESH:D001241	7422	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|suppressing suppressing|dobj|expression expression|amod|END_ENTITY	NO-donating aspirin inhibits angiogenesis by suppressing VEGF expression in HT-29 human colon_cancer mouse xenografts .
9334204	0	aspirin	75,82	activator_protein-1	36,55	aspirin	activator protein-1	MESH:D001241	16476(Tax:10090)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Inhibition of ultraviolet B-induced activator_protein-1 -LRB- AP-1 -RRB- activity by aspirin in AP-1-luciferase transgenic_mice .
9092536	0	aspirin	76,83	activator_protein_1	14,33	aspirin	activator protein 1	MESH:D001241	16476(Tax:10090)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activity activity|amod|END_ENTITY	Inhibition of activator_protein_1 activity and neoplastic transformation by aspirin .
10826452	0	aspirin	5,12	angiotensin-converting_enzyme	49,78	aspirin	angiotensin-converting enzyme	MESH:D001241	1636	Chemical	Gene	attenuate|nsubj|START_ENTITY attenuate|dobj|effects effects|nmod|inhibition inhibition|amod|END_ENTITY	Does aspirin attenuate the beneficial effects of angiotensin-converting_enzyme inhibition in heart_failure ?
10841227	0	aspirin	151,158	angiotensin-converting_enzyme	26,55	aspirin	angiotensin-converting enzyme	MESH:D001241	1636	Chemical	Gene	presence|nmod|START_ENTITY similar|nmod|presence similar|nsubj|effects effects|nmod|treatment treatment|amod|END_ENTITY	Clinical effects of early angiotensin-converting_enzyme inhibitor treatment for acute_myocardial_infarction are similar in the presence and absence of aspirin : systematic overview of individual data from 96,712 randomized patients .
11020393	0	aspirin	29,36	angiotensin-converting_enzyme	51,80	aspirin	angiotensin-converting enzyme	MESH:D001241	1636	Chemical	Gene	effects|nmod|START_ENTITY Evaluation|nmod|effects combined|nsubj|Evaluation combined|nmod|inhibitors inhibitors|amod|END_ENTITY	Evaluation of the effects of aspirin combined with angiotensin-converting_enzyme inhibitors in patients with coronary_artery_disease .
11179543	0	aspirin	19,26	angiotensin-converting_enzyme	86,115	aspirin	angiotensin-converting enzyme	MESH:D001241	1636	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|amod|END_ENTITY	Effect of combined aspirin and angiotensin-converting_enzyme inhibitor therapy versus angiotensin-converting_enzyme inhibitor therapy alone on readmission rates in heart_failure .
11496056	0	aspirin	5,12	angiotensin-converting_enzyme	37,66	aspirin	angiotensin-converting enzyme	MESH:D001241	1636	Chemical	Gene	attenuate|nsubj|START_ENTITY attenuate|dobj|effect effect|nmod|inhibitors inhibitors|amod|END_ENTITY	Does aspirin attenuate the effect of angiotensin-converting_enzyme inhibitors in hypertension or heart_failure ?
12133013	0	aspirin	5,12	angiotensin-converting_enzyme	37,66	aspirin	angiotensin-converting enzyme	MESH:D001241	1636	Chemical	Gene	attenuate|nsubj|START_ENTITY attenuate|dobj|effect effect|nmod|inhibitors inhibitors|amod|END_ENTITY	Does aspirin attenuate the effect of angiotensin-converting_enzyme inhibitors on health outcomes of very old patients with heart_failure ?
12595854	0	aspirin	79,86	angiotensin-converting_enzyme	24,53	aspirin	angiotensin-converting enzyme	MESH:D001241	1636	Chemical	Gene	inhibitors|nmod|START_ENTITY inhibitors|amod|END_ENTITY	Antiplatelet effects of angiotensin-converting_enzyme inhibitors compared with aspirin and clopidogrel : a pilot study with whole-blood aggregometry .
9604941	0	aspirin	11,18	angiotensin-converting_enzyme	22,51	aspirin	angiotensin-converting enzyme	MESH:D001241	1636	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|inhibition inhibition|amod|END_ENTITY	Effects of aspirin on angiotensin-converting_enzyme inhibition and left ventricular dilation one year after acute myocardial_infarction .
9758314	0	aspirin	5,12	angiotensin-converting_enzyme	56,85	aspirin	angiotensin-converting enzyme	MESH:D001241	1636	Chemical	Gene	interfere|nsubj|START_ENTITY interfere|nmod|efficacy efficacy|nmod|inhibitors inhibitors|amod|END_ENTITY	Does aspirin interfere with the therapeutic efficacy of angiotensin-converting_enzyme inhibitors in hypertension or congestive_heart_failure ?
1680084	0	aspirin	9,16	angiotensin_II	73,87	aspirin	angiotensin II	MESH:D001241	183	Chemical	Gene	START_ENTITY|amod|sensitive sensitive|nmod|END_ENTITY	Low-dose aspirin and vascular response in pregnant patients sensitive to angiotensin_II .
3799752	0	aspirin	19,26	angiotensin_II	30,44	aspirin	angiotensin II	MESH:D001241	183	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|response response|amod|END_ENTITY	Effect of low-dose aspirin on angiotensin_II pressor response in human pregnancy .
9024091	0	aspirin	30,37	angiotensin_II	193,207	aspirin	angiotensin II	MESH:D001241	183	Chemical	Gene	actions|dep|START_ENTITY inhibits|nsubj|actions inhibits|advcl|affecting affecting|dobj|END_ENTITY	Drug actions in preeclampsia : aspirin , but not magnesium_chloride or dihydralazine , differentially inhibits cultured human trophoblast release of thromboxane and prostacyclin without affecting angiotensin_II , endothelin-1 , or leukotriene B4 secretion .
20005558	0	aspirin	28,35	apoE	89,93	aspirin	apoE	MESH:D001241	11816(Tax:10090)	Chemical	Gene	administration|compound|START_ENTITY effect|nmod|administration effect|nmod|END_ENTITY	The effect of the long term aspirin administration on the progress of atherosclerosis in apoE - / - LDLR - / - double knockout mouse .
2139442	0	aspirin	114,121	beta-thromboglobulin	17,37	aspirin	beta-thromboglobulin	MESH:D001241	5473	Chemical	Gene	response|nmod|START_ENTITY END_ENTITY|dep|response	Increased plasma beta-thromboglobulin in patients with coronary artery vein graft occlusion : response to low dose aspirin .
11849193	0	aspirin	10,17	bradykinin	37,47	aspirin	bradykinin	MESH:D001241	3827	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of aspirin on vasodilation to bradykinin and substance_P in patients with heart_failure treated with ACE inhibitor .
5909493	0	aspirin	14,21	bradykinin	91,101	aspirin	bradykinin	MESH:D001241	3827	Chemical	Gene	effect|nmod|START_ENTITY flow|nsubj|effect flow|nmod|injection injection|nmod|END_ENTITY	The effect of aspirin on pain and hand blood flow responses to intra-arterial injection of bradykinin in man .
16914369	0	aspirin	11,18	brain_natriuretic_peptide	45,70	aspirin	brain natriuretic peptide	MESH:D001241	4879	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of aspirin and clopidogrel on plasma brain_natriuretic_peptide in patients with heart_failure receiving ACE inhibitors .
25035343	0	aspirin	74,81	catechol-O-methyltransferase	17,45	aspirin	catechol-O-methyltransferase	MESH:D001241	1312	Chemical	Gene	effects|nmod|START_ENTITY effects|amod|END_ENTITY	Polymorphisms in catechol-O-methyltransferase modify treatment effects of aspirin on risk of cardiovascular_disease .
23653362	0	aspirin	62,69	ciliary_neurotrophic_factor	17,44	aspirin	ciliary neurotrophic factor	MESH:D001241	12803(Tax:10090)	Chemical	Gene	astrocytes|nmod|START_ENTITY END_ENTITY|nmod|astrocytes	Up-regulation of ciliary_neurotrophic_factor in astrocytes by aspirin : implications for remyelination in multiple_sclerosis .
22001128	4	aspirin	595,602	cox-2	784,789	aspirin	cox-2	MESH:D001241	4513	Chemical	Gene	regimens|compound|START_ENTITY achieve|nsubj|regimens feasible|advcl|achieve feasible|dep|decrease decrease|dobj|expression expression|amod|END_ENTITY	Since safe aspirin regimens can only achieve a partial and transitory inhibition of cox-2 , it may be feasible to complement the cancer-protective benefit of aspirin with other measures which decrease cox-2 expression or which limit the bioactivity of cox-2-derived PGE2 .
22001128	4	aspirin	741,748	cox-2	784,789	aspirin	cox-2	MESH:D001241	4513	Chemical	Gene	benefit|nmod|START_ENTITY complement|dobj|benefit feasible|xcomp|complement feasible|dep|decrease decrease|dobj|expression expression|amod|END_ENTITY	Since safe aspirin regimens can only achieve a partial and transitory inhibition of cox-2 , it may be feasible to complement the cancer-protective benefit of aspirin with other measures which decrease cox-2 expression or which limit the bioactivity of cox-2-derived PGE2 .
19390185	0	aspirin	50,57	cyclooxygenase-1	13,29	aspirin	cyclooxygenase-1	MESH:D001241	5742	Chemical	Gene	response|compound|START_ENTITY response|amod|END_ENTITY	Influence of cyclooxygenase-1 genotype on ex vivo aspirin response in patients at risk for stroke .
12960371	0	aspirin	84,91	cyclooxygenase-2	27,43	aspirin	cyclooxygenase-2	MESH:D001241	5743	Chemical	Gene	inhibitor|nmod|START_ENTITY inhibitor|amod|END_ENTITY	Interaction of a selective cyclooxygenase-2 inhibitor with aspirin and NO-releasing aspirin in the human gastric mucosa .
12621391	0	aspirin	39,46	cytochrome_P450	50,65	aspirin	cytochrome P450	MESH:D001241	4051	Chemical	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	Isozyme-specific induction of low-dose aspirin on cytochrome_P450 in healthy subjects .
1353466	0	aspirin	10,17	epidermal_growth_factor	38,61	aspirin	epidermal growth factor	MESH:D001241	1950	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Effect of aspirin and indomethacin on epidermal_growth_factor secretion in duodenal tissue fragments cultivated in vitro .
17719296	0	aspirin	70,77	erythropoietin	29,43	aspirin	erythropoietin	MESH:D001241	2056	Chemical	Gene	action|nmod|START_ENTITY END_ENTITY|nmod|action	Effects of recombinant human erythropoietin on antiplatelet action of aspirin and clopidogrel in healthy subjects : results of a double-blind , placebo-controlled randomized trial .
8922487	0	aspirin	118,125	erythropoietin	84,98	aspirin	erythropoietin	MESH:D001241	2056	Chemical	Gene	synthesis|nmod|START_ENTITY synthesis|nmod|END_ENTITY	Stimulation of newborn-like hemoglobin synthesis in adult rats by recombinant human erythropoietin and suppression by aspirin .
1843907	0	aspirin	11,18	formyl-meth-leu-phe	28,47	aspirin	formyl-meth-leu-phe	MESH:D001241	2357	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|END_ENTITY	-LSB- Effect of aspirin on FMLP -LRB- formyl-meth-leu-phe -RRB- - stimulated leukocytes in patients with asthma and hypersensitivity to aspirin -RSB- .
19145733	0	aspirin	9,16	gastrokine-1	48,60	aspirin	gastrokine-1	MESH:D001241	56287	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|nmod|END_ENTITY	Low-dose aspirin reduces the gene expression of gastrokine-1 in the antral mucosa of healthy subjects .
16214444	0	aspirin	56,63	glycoprotein_Ia	179,194	aspirin	glycoprotein Ia	MESH:D001241	22915	Chemical	Gene	treatment|compound|START_ENTITY sustained|dobj|treatment sustained|nmod|coronary_heart_disease coronary_heart_disease|nmod|polymorphism polymorphism|nmod|gene gene|compound|END_ENTITY	Variability in platelet_aggregation following sustained aspirin and clopidogrel treatment in patients with coronary_heart_disease and influence of the 807_C / T polymorphism of the glycoprotein_Ia gene .
17264949	0	aspirin	122,129	glycoprotein_Ia	56,71	aspirin	glycoprotein Ia	MESH:D001241	22915	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Lack of association between the 807_C / T polymorphism of glycoprotein_Ia gene and post-treatment platelet reactivity after aspirin and clopidogrel in patients with acute_coronary_syndrome .
20224668	0	aspirin	71,78	interleukin-13	35,49	aspirin	interleukin-13	MESH:D001241	3596	Chemical	Gene	polymorphism|nmod|START_ENTITY polymorphism|amod|END_ENTITY	No evidence of association between interleukin-13 gene polymorphism in aspirin intolerant chronic urticaria .
14504184	0	aspirin	88,95	interleukin-1beta	9,26	aspirin	interleukin-1beta	MESH:D001241	3553	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|dep|effects	Enhanced interleukin-1beta in hypercholesterolemia : effects of simvastatin and low-dose aspirin .
11238116	0	aspirin	74,81	interleukin-4	24,37	aspirin	interleukin-4	MESH:D001241	3565	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|expression expression|compound|END_ENTITY	Selective inhibition of interleukin-4 gene expression in human T cells by aspirin .
8611656	0	aspirin	69,76	malate_dehydrogenase	34,54	aspirin	malate dehydrogenase	MESH:D001241	4199	Chemical	Gene	protection|nmod|START_ENTITY protection|amod|END_ENTITY	Glycation-induced inactivation of malate_dehydrogenase protection by aspirin and a lens molecular chaperone , alpha-crystallin .
16546864	0	aspirin	15,22	maspin	42,48	aspirin	maspin	MESH:D001241	5268	Chemical	Gene	START_ENTITY|nmod|level level|compound|END_ENTITY	Restoration by aspirin of impaired plasma maspin level in human breast_cancer .
25225590	0	aspirin	11,18	nuclear_factor-kB	40,57	aspirin	nuclear factor-kB	MESH:D001241	81736(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of aspirin on the expression of nuclear_factor-kB in a rat model of acute_pulmonary_embolism .
18519978	0	aspirin	69,76	paraoxonase_1	13,26	aspirin	paraoxonase 1	MESH:D001241	18979(Tax:10090)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|expression expression|compound|END_ENTITY	Induction of paraoxonase_1 and apolipoprotein_A-I gene expression by aspirin .
11097175	0	aspirin	138,145	peptidylglycine_alpha-amidating_monooxygenase	71,116	aspirin	peptidylglycine alpha-amidating monooxygenase	MESH:D001241	5066	Chemical	Gene	metabolism|nmod|START_ENTITY END_ENTITY|nmod|metabolism	Amidation of salicyluric_acid and gentisuric_acid : a possible role for peptidylglycine_alpha-amidating_monooxygenase in the metabolism of aspirin .
1829277	0	aspirin	35,42	plasmin	15,22	aspirin	plasmin	MESH:D001241	5340	Chemical	Gene	Stimulation|nmod|START_ENTITY Stimulation|nmod|activity activity|compound|END_ENTITY	Stimulation of plasmin activity by aspirin .
2867260	0	aspirin	9,16	pregnancy-induced_hypertension	26,56	aspirin	pregnancy-induced hypertension	MESH:D001241	5177	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|dobj|END_ENTITY	Low-dose aspirin prevents pregnancy-induced_hypertension and pre-eclampsia in angiotensin-sensitive primigravidae .
19805643	0	aspirin	35,42	renin	53,58	aspirin	renin	MESH:D001241	5972	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activity activity|compound|END_ENTITY	Time-dependent effects of low-dose aspirin on plasma renin activity , aldosterone , cortisol , and catecholamines .
22362503	0	aspirin	36,43	thrombin	7,15	aspirin	thrombin	MESH:D001241	2147	Chemical	Gene	inhibitor|nmod|START_ENTITY inhibitor|compound|END_ENTITY	Direct thrombin inhibitor -LRB- DTI -RRB- vs. aspirin in primary total hip and knee replacement using wound ooze as the primary outcome measure .
8629598	0	aspirin	11,18	thrombin	32,40	aspirin	thrombin	MESH:D001241	2147	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|generation generation|compound|END_ENTITY	Effects of aspirin on status of thrombin generation in atrial_fibrillation .
8696958	0	aspirin	37,44	thrombin	14,22	aspirin	thrombin	MESH:D001241	2147	Chemical	Gene	generation|nmod|START_ENTITY generation|compound|END_ENTITY	Inhibition of thrombin generation by aspirin is blunted in hypercholesterolemia .
8171410	0	aspirin	10,17	tissue_factor	56,69	aspirin	tissue factor	MESH:D001241	101909187	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of aspirin and clopidogrel on platelet-dependent tissue_factor expression in endothelial cells .
2529003	0	aspirin	55,62	tissue_plasminogen_activator	14,42	aspirin	tissue plasminogen activator	MESH:D001241	100128998	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activity activity|compound|END_ENTITY	Inhibition of tissue_plasminogen_activator activity by aspirin in vivo and its relationship to levels of tissue_plasminogen_activator inhibitor antigen , plasminogen activator and their complexes .
14573775	0	aspirin	149,156	tumor_necrosis_factor-alpha	103,130	aspirin	tumor necrosis factor-alpha	MESH:D001241	7124	Chemical	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	Expression of the angiogenic factor thymidine phosphorylase in THP-1 monocytes : induction by autocrine tumor_necrosis_factor-alpha and inhibition by aspirin .
16942942	0	aspirin	11,18	vascular_endothelial_growth_factor	37,71	aspirin	vascular endothelial growth factor	MESH:D001241	7422	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of aspirin on intra-platelet vascular_endothelial_growth_factor , angiopoietin-1 , and p-selectin levels in hypertensive patients .
18674921	0	astatine	39,47	insulin	53,60	astatine	insulin	MESH:D001246	3630	Chemical	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	Complexation study on no-carrier-added astatine with insulin : a candidate radiopharmaceutical .
22707263	0	astaxanthin	23,34	PPAR-a	38,44	astaxanthin	PPAR-a	MESH:C005948	5465	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	The natural carotenoid astaxanthin , a PPAR-a agonist and PPAR-y antagonist , reduces hepatic lipid accumulation by rewiring the transcriptome in lipid-loaded hepatocytes .
12386130	0	astemizole	85,95	CYP2J2	15,21	astemizole	CYP2J2	MESH:D016589	1573	Chemical	Gene	START_ENTITY|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of CYP2J2 on the intestinal first-pass metabolism of antihistamine drug , astemizole .
19879122	0	astilbin	18,26	ACE	0,3	astilbin	ACE	MESH:C099069	1636	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|END_ENTITY	ACE inhibition by astilbin isolated from Erythroxylum gonocladum -LRB- Mart . -RRB-
20587320	0	astilbin	12,20	TNF_alpha	42,51	astilbin	TNF alpha	MESH:C099069	21926(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of astilbin on the expression of TNF_alpha and IL-10 in liver warm ischemia-reperfusion injury -RSB- .
9635510	0	astilbin	81,89	lipoprotein_lipase	50,68	astilbin	lipoprotein lipase	MESH:C099069	24539(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Enhancement of the vanadate-stimulated release of lipoprotein_lipase activity by astilbin from the leaves of Engelhardtia chrysolepis .
22766709	0	astragalin	14,24	VEGF	32,36	astragalin	VEGF	MESH:C001579	83785(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|production production|compound|END_ENTITY	The effect of astragalin on the VEGF production of cultured M ller cells under high glucose conditions .
21924028	0	astragaloside	12,25	IGF-1	29,34	astragaloside	IGF-1	null	16000(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	-LSB- Effects of astragaloside on IGF-1 and associated protein expression in mice with acute viral_myocarditis -RSB- .
22097737	0	astragaloside_IV	39,55	ERK1/2	11,17	astragaloside IV	ERK1/2	MESH:C052064	5595;5594	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	-LSB- Effect of ERK1/2 signaling pathway on astragaloside_IV protects H9c2 cells against H2O2-induced oxidative injury -RSB- .
20945275	0	astragaloside_IV	11,27	IFN-gamma	31,40	astragaloside IV	IFN-gamma	MESH:C052064	15978(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|level level|amod|END_ENTITY	Effects of astragaloside_IV on IFN-gamma level and prolonged airway_dysfunction in a murine model of chronic_asthma .
21975818	0	astragaloside_IV	21,37	matrix_metalloproteinase-1	46,72	astragaloside IV	matrix metalloproteinase-1	MESH:C052064	4312	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|amod|END_ENTITY	Protective effect of astragaloside_IV against matrix_metalloproteinase-1 expression in ultraviolet-irradiated human dermal fibroblasts .
10411571	0	astressin	79,88	CRF	108,111	astressin	CRF	MESH:C104416	81648(Tax:10116)	Chemical	Gene	injection|appos|START_ENTITY blocks|nsubj|injection blocks|dobj|END_ENTITY	Peripheral injection of a new corticotropin-releasing_factor -LRB- CRF -RRB- antagonist , astressin , blocks peripheral CRF - and abdominal surgery-induced delayed gastric_emptying in rats .
10411571	0	astressin	79,88	CRF	62,65	astressin	CRF	MESH:C104416	81648(Tax:10116)	Chemical	Gene	injection|appos|START_ENTITY injection|nmod|antagonist antagonist|appos|END_ENTITY	Peripheral injection of a new corticotropin-releasing_factor -LRB- CRF -RRB- antagonist , astressin , blocks peripheral CRF - and abdominal surgery-induced delayed gastric_emptying in rats .
16624394	5	astressin	1013,1022	CRF	935,938	astressin	TRH	MESH:C104416	7200	Chemical	Gene	diminished|nmod|START_ENTITY attenuated|advcl|diminished attenuated|nmod|astressin astressin|appos|antagonist antagonist|compound|END_ENTITY	The TRH-induced increase_in_HP could not be attenuated by astressin , a CRF receptor antagonist , while the effect of CRF was completely diminished by astressin .
16624394	5	astressin	922,931	CRF	935,938	astressin	TRH	MESH:C104416	7200	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	The TRH-induced increase_in_HP could not be attenuated by astressin , a CRF receptor antagonist , while the effect of CRF was completely diminished by astressin .
17917258	0	astressin	81,90	CRF	54,57	astressin	CRF	MESH:C104416	81648(Tax:10116)	Chemical	Gene	antagonist|compound|START_ENTITY agonist|dep|antagonist agonist|appos|END_ENTITY	Effects of urocortin , corticotropin-releasing_factor -LRB- CRF -RRB- receptor agonist , and astressin , CRF receptor antagonist , on the sleep-wake pattern : analysis by radiotelemetry in conscious rats .
17917258	0	astressin	81,90	CRF	92,95	astressin	CRF	MESH:C104416	81648(Tax:10116)	Chemical	Gene	antagonist|compound|START_ENTITY antagonist|dep|END_ENTITY	Effects of urocortin , corticotropin-releasing_factor -LRB- CRF -RRB- receptor agonist , and astressin , CRF receptor antagonist , on the sleep-wake pattern : analysis by radiotelemetry in conscious rats .
16256445	0	astressin	63,72	corticotropin_releasing_factor	12,42	astressin	corticotropin releasing factor	MESH:C104416	81648(Tax:10116)	Chemical	Gene	role|acl|START_ENTITY role|nmod|END_ENTITY	The role of corticotropin_releasing_factor and its antagonist , astressin , on micturition in the rat .
26790728	0	asymmetric_dimethylarginine	44,71	Apolipoprotein_E	0,16	asymmetric dimethylarginine	Apolipoprotein E	CHEBI:17929	348	Chemical	Gene	modulation|nmod|START_ENTITY modulation|amod|END_ENTITY	Apolipoprotein_E polymorphism modulation of asymmetric_dimethylarginine in hypertensive patients is determined by renal function .
18585997	0	atRA	0,4	NEDD9	19,24	atRA	NEDD9	null	4739	Chemical	Gene	Regulation|compound|START_ENTITY Regulation|nmod|END_ENTITY	atRA Regulation of NEDD9 , a gene involved in neurite outgrowth and cell adhesion .
9867068	0	atenolol	91,99	angiotensin-converting_enzyme	10,39	atenolol	angiotensin-converting enzyme	MESH:D001262	1636	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|inhibition inhibition|amod|END_ENTITY	Effect of angiotensin-converting_enzyme inhibition with perindopril and beta-blockade with atenolol on retinal blood flow in hypertensive diabetic subjects .
21247745	0	atenolol	34,42	beta-1	4,10	atenolol	beta-1	MESH:D001262	3779	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	The beta-1 adrenergic antagonist , atenolol , decreases acylation stimulating protein , exercise capacity and plasma free fatty_acids in men with type 2 diabetes .
2574052	0	atenolol	87,95	beta_1-adrenoceptor	54,73	atenolol	beta 1-adrenoceptor	MESH:D001262	153	Chemical	Gene	metoprolol|amod|START_ENTITY antagonists|dep|metoprolol antagonists|amod|END_ENTITY	CNS-related subjective symptoms during treatment with beta_1-adrenoceptor antagonists -LRB- atenolol , metoprolol -RRB- : two double-blind placebo controlled studies .
2581073	0	atenolol	112,120	beta_1-adrenoceptor	78,97	atenolol	beta 1-adrenoceptor	MESH:D001262	24925(Tax:10116)	Chemical	Gene	blockade|nmod|START_ENTITY blockade|amod|END_ENTITY	Left ventricular performance in spontaneously hypertensive rats after chronic beta_1-adrenoceptor blockade with atenolol .
6587734	0	atenolol	45,53	beta_1-adrenoceptor	17,36	atenolol	beta 1-adrenoceptor	MESH:D001262	153	Chemical	Gene	START_ENTITY|nsubj|Influence Influence|nmod|blocker blocker|amod|END_ENTITY	Influence of the beta_1-adrenoceptor blocker atenolol on antenatal cardiotocography .
3889077	0	atenolol	10,18	beta_2-microglobulin	28,48	atenolol	beta 2-microglobulin	MESH:D001262	567	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|level level|amod|END_ENTITY	Effect of atenolol on serum beta_2-microglobulin level in hypertensive diabetic patients .
1311892	0	atenolol	14,22	growth_hormone	30,44	atenolol	growth hormone	MESH:D001262	2688	Chemical	Gene	START_ENTITY|nmod|response response|amod|END_ENTITY	The effect of atenolol on the growth_hormone response to growth_hormone-releasing_hormone in obese children .
2882405	0	atenolol	51,59	growth_hormone	115,129	atenolol	growth hormone	MESH:D001262	2688	Chemical	Gene	receptor-blockade|nmod|START_ENTITY enhances|nsubj|receptor-blockade enhances|dobj|release release|amod|END_ENTITY	Selective beta 1-adrenergic receptor-blockade with atenolol enhances growth_hormone_releasing_hormone and mediated growth_hormone release in man .
1311892	0	atenolol	14,22	growth_hormone-releasing_hormone	57,89	atenolol	growth hormone-releasing hormone	MESH:D001262	2691	Chemical	Gene	effect|nmod|START_ENTITY effect|acl|END_ENTITY	The effect of atenolol on the growth_hormone response to growth_hormone-releasing_hormone in obese children .
2882405	0	atenolol	51,59	growth_hormone_releasing_hormone	69,101	atenolol	growth hormone releasing hormone	MESH:D001262	2691	Chemical	Gene	receptor-blockade|nmod|START_ENTITY enhances|nsubj|receptor-blockade enhances|dobj|release release|amod|END_ENTITY	Selective beta 1-adrenergic receptor-blockade with atenolol enhances growth_hormone_releasing_hormone and mediated growth_hormone release in man .
10694831	0	atenolol	98,106	insulin	13,20	atenolol	insulin	MESH:D001262	3630	Chemical	Gene	treatment|nmod|START_ENTITY Induction|dep|treatment Induction|nmod|resistance resistance|compound|END_ENTITY	Induction of insulin resistance by beta-blockade but not ACE-inhibition : long-term treatment with atenolol or trandolapril .
2043298	0	atenolol	29,37	insulin	65,72	atenolol	insulin	MESH:D001262	3630	Chemical	Gene	effects|nmod|START_ENTITY Comparison|nmod|effects Comparison|nmod|END_ENTITY	Comparison of the effects of atenolol and nifedipine on glucose , insulin , and lipid metabolism in patients with hypertension .
2500169	0	atenolol	45,53	insulin	15,22	atenolol	insulin	MESH:D001262	3630	Chemical	Gene	treatment|nmod|START_ENTITY END_ENTITY|nmod|treatment	Sensitivity to insulin during treatment with atenolol and metoprolol : a randomised , double blind study of effects on carbohydrate and lipoprotein metabolism in hypertensive patients .
24981592	0	atenolol	84,92	organic_cation_transporter_2	38,66	atenolol	organic cation transporter 2	MESH:D001262	29503(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of age-related decrease of renal organic_cation_transporter_2 in the effect of atenolol on renal excretion of metformin in rats .
304291	0	atenolol	10,18	renin	66,71	atenolol	renin	MESH:D001262	5972	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|compound|END_ENTITY	Effect of atenolol , a new cardioselective beta-blocker , on plasma renin activity in treatment of hypertension .
6384568	0	atenolol	16,24	renin	48,53	atenolol	renin	MESH:D001262	5972	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Acute effect of atenolol on hemodynamic , plasma renin activity and plasma aldosterone concentration in the once daily oral administration .
19997977	0	atilmotin	10,19	motilin	23,30	atilmotin	motilin	MESH:C508748	4295	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Effect of atilmotin , a motilin receptor agonist , on esophageal , lower esophageal sphincter , and gastric pressures .
20691787	0	atomoxetine	24,35	BDNF	49,53	atomoxetine	BDNF	MESH:C041930	24225(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|expression expression|amod|END_ENTITY	Sub-chronic exposure to atomoxetine up-regulates BDNF expression and signalling in the brain of adolescent spontaneously hypertensive rats : comparison with methylphenidate .
24346747	0	atomoxetine	44,55	CYP2C19	11,18	atomoxetine	CYP2C19	MESH:C041930	1557	Chemical	Gene	polymorphisms|nmod|START_ENTITY polymorphisms|nummod|END_ENTITY	Effects of CYP2C19 genetic polymorphisms on atomoxetine pharmacokinetics .
17515448	0	atomoxetine	41,52	Norepinephrine_transporter	0,26	atomoxetine	Norepinephrine transporter	MESH:C041930	6530	Chemical	Gene	blockade|nmod|START_ENTITY blockade|amod|END_ENTITY	Norepinephrine_transporter blockade with atomoxetine induces hypertension in patients with impaired autonomic function .
19300997	0	atomoxetine	50,61	norepinephrine_transporter	10,36	atomoxetine	norepinephrine transporter	MESH:C041930	613238(Tax:9544)	Chemical	Gene	occupancy|nmod|START_ENTITY occupancy|compound|END_ENTITY	Saturated norepinephrine_transporter occupancy by atomoxetine relevant to clinical doses : a rhesus_monkey study with -LRB- S , S -RRB- - -LSB- -LRB- 18 -RRB- F -RSB- FMeNER-D -LRB- 2 -RRB- .
19387424	0	atomoxetine	104,115	norepinephrine_transporter	19,45	atomoxetine	norepinephrine transporter	MESH:C041930	6530	Chemical	Gene	associated|xcomp|START_ENTITY associated|nsubjpass|Slc6a2 Slc6a2|amod|haplotype haplotype|nmod|END_ENTITY	A haplotype of the norepinephrine_transporter -LRB- Net -RRB- gene Slc6a2 is associated with clinical response to atomoxetine in attention-deficit_hyperactivity_disorder -LRB- ADHD -RRB- .
26774596	0	atomoxetine	134,145	norepinephrine_transporter	34,60	atomoxetine	norepinephrine transporter	MESH:C041930	83511(Tax:10116)	Chemical	Gene	doses|nmod|START_ENTITY cognitive_flexibility|nmod|doses basis|nmod|cognitive_flexibility changes|dep|basis changes|nmod|density density|compound|END_ENTITY	Age-related changes in prefrontal norepinephrine_transporter density : The basis for improved cognitive_flexibility after low doses of atomoxetine in adolescent rats .
23625977	0	atorvastatin	95,107	APOE	111,115	atorvastatin	APOE	MESH:C065179	11816(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|3Leiden 3Leiden|compound|END_ENTITY	Osteoarthritis development is induced by increased dietary cholesterol and can be inhibited by atorvastatin in APOE * 3Leiden .
18374327	0	atorvastatin	43,55	Adiponectin	0,11	atorvastatin	Adiponectin	MESH:C065179	9370	Chemical	Gene	treatment|compound|START_ENTITY increased|nmod|treatment increased|nsubjpass|levels levels|compound|END_ENTITY	Adiponectin plasma levels are increased by atorvastatin treatment in subjects at high cardiovascular risk .
22001104	0	atorvastatin	68,80	ApoE	169,173	atorvastatin	ApoE	MESH:C065179	11816(Tax:10090)	Chemical	Gene	using|dobj|START_ENTITY strategies|acl|using modify|nsubj|strategies modify|nmod|mice mice|amod|END_ENTITY	Anti-inflammatory and anti-thrombotic intervention strategies using atorvastatin , clopidogrel and knock-down of CD40L do not modify radiation-induced atherosclerosis in ApoE null mice .
22074026	0	atorvastatin	124,136	Apolipoprotein_E	0,16	atorvastatin	Apolipoprotein E	MESH:C065179	348	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|expression expression|amod|END_ENTITY	Apolipoprotein_E mRNA expression in mononuclear cells from normolipidemic and hypercholesterolemic individuals treated with atorvastatin .
22004509	0	atorvastatin	48,60	Biliverdin_reductase-A	0,22	atorvastatin	Biliverdin reductase-A	MESH:C065179	475867(Tax:9615)	Chemical	Gene	target|nmod|START_ENTITY END_ENTITY|dep|target	Biliverdin_reductase-A : a novel drug target for atorvastatin in a dog pre-clinical model of Alzheimer_disease .
11996943	0	atorvastatin	10,22	C-reactive_protein	59,77	atorvastatin	C-reactive protein	MESH:C065179	1401	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|nmod|END_ENTITY	Effect of atorvastatin and bezafibrate on plasma levels of C-reactive_protein in combined -LRB- mixed -RRB- hyperlipidemia .
12009719	0	atorvastatin	22,34	C-reactive_protein	38,56	atorvastatin	C-reactive protein	MESH:C065179	1401	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Short-term effects of atorvastatin on C-reactive_protein .
12595863	0	atorvastatin	10,22	C-reactive_protein	48,66	atorvastatin	C-reactive protein	MESH:C065179	1401	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of atorvastatin and pravastatin on serum C-reactive_protein .
14981605	0	atorvastatin	5,17	C-reactive_protein	34,52	atorvastatin	C-reactive protein	MESH:C065179	1401	Chemical	Gene	influence|compound|START_ENTITY serum|nsubj|influence serum|dobj|levels levels|amod|END_ENTITY	Does atorvastatin influence serum C-reactive_protein levels in patients on long-term hemodialysis ?
15842965	0	atorvastatin	11,23	C-reactive_protein	73,91	atorvastatin	C-reactive protein	MESH:C065179	1401	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|fasting fasting|amod|END_ENTITY	Effects of atorvastatin versus other statins on fasting and postprandial C-reactive_protein and lipoprotein-associated_phospholipase_A2 in patients with coronary_heart_disease versus control subjects .
16324343	0	atorvastatin	12,24	C-reactive_protein	50,68	atorvastatin	C-reactive protein	MESH:C065179	1401	Chemical	Gene	Effects|nmod|START_ENTITY hypersensitive|nsubj|Effects hypersensitive|xcomp|END_ENTITY	-LSB- Effects of atorvastatin on plasma hypersensitive C-reactive_protein and interleukin-6 in patients with acute cerebral_infarction -RSB- .
16945213	0	atorvastatin	64,76	C-reactive_protein	22,40	atorvastatin	C-reactive protein	MESH:C065179	1401	Chemical	Gene	treatment|compound|START_ENTITY associated|nmod|treatment associated|nsubjpass|Change Change|acl|circulating circulating|dobj|END_ENTITY	Change in circulating C-reactive_protein is not associated with atorvastatin treatment in Alzheimer 's _ disease .
17560879	0	atorvastatin	73,85	C-reactive_protein	98,116	atorvastatin	C-reactive protein	MESH:C065179	1401	Chemical	Gene	Comparison|nmod|START_ENTITY Comparison|acl|reducing reducing|dobj|levels levels|compound|END_ENTITY	Comparison of effects of ezetimibe/simvastatin versus simvastatin versus atorvastatin in reducing C-reactive_protein and low-density lipoprotein cholesterol levels .
17920365	0	atorvastatin	51,63	C-reactive_protein	95,113	atorvastatin	C-reactive protein	MESH:C065179	1401	Chemical	Gene	START_ENTITY|nmod|achievement achievement|nmod|END_ENTITY	Comparison of effectiveness of rosuvastatin versus atorvastatin on the achievement of combined C-reactive_protein -LRB- < 2 mg/L -RRB- and low-density lipoprotein cholesterol -LRB- < 70 mg/dl -RRB- targets in patients with type_2_diabetes_mellitus -LRB- from the ANDROMEDA study -RRB- .
19270348	0	atorvastatin	11,23	C-reactive_protein	68,86	atorvastatin	C-reactive protein	MESH:C065179	1401	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of atorvastatin on lipopolysaccharide-induced expression of C-reactive_protein in human pulmonary epithelial cells -RSB- .
19343161	0	atorvastatin	52,64	C-reactive_protein	10,28	atorvastatin	C-reactive protein	MESH:C065179	1401	Chemical	Gene	using|dobj|START_ENTITY levels|acl|using levels|amod|END_ENTITY	Targeting C-reactive_protein levels using high-dose atorvastatin before coronary artery bypass graft surgery .
20805273	0	atorvastatin	21,33	C-reactive_protein	63,81	atorvastatin	C-reactive protein	MESH:C065179	1401	Chemical	Gene	effects|nmod|START_ENTITY compared|nsubj|effects compared|nmod|concentrations concentrations|amod|END_ENTITY	Disparate effects of atorvastatin compared with simvastatin on C-reactive_protein concentrations in patients with type 2 diabetes .
22088250	0	atorvastatin	16,28	C-reactive_protein	32,50	atorvastatin	C-reactive protein	MESH:C065179	12944(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY -LSB-|dobj|effects -LSB-|nmod|expression expression|compound|END_ENTITY	-LSB- The effects of atorvastatin on C-reactive_protein induced Toll-like_receptor_4 expression on CD14 + monocyte -RSB- .
22321227	0	atorvastatin	196,208	C-reactive_protein	38,56	atorvastatin	C-reactive protein	MESH:C065179	1401	Chemical	Gene	-RSB-|compound|START_ENTITY impact|nmod|-RSB- Association|dep|impact Association|nmod|END_ENTITY	-LSB- Association between high sensitivity C-reactive_protein and contrast induced acute_kidney_injury in patients with acute_coronary_syndrome undergoing percutaneous coronary intervention : impact of atorvastatin -RSB- .
22704860	0	atorvastatin	131,143	C-reactive_protein	24,42	atorvastatin	C-reactive protein	MESH:C065179	1401	Chemical	Gene	value|nmod|START_ENTITY value|nmod|END_ENTITY	The predictive value of C-reactive_protein on recurrence of atrial_fibrillation after cardioversion with or without treatment with atorvastatin .
23218801	0	atorvastatin	11,23	C-reactive_protein	33,51	atorvastatin	C-reactive protein	MESH:C065179	1401	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|metabolism metabolism|amod|END_ENTITY	Effects of atorvastatin on human C-reactive_protein metabolism .
25538368	0	atorvastatin	32,44	C-reactive_protein	63,81	atorvastatin	C-reactive protein	MESH:C065179	1401	Chemical	Gene	high|nmod|START_ENTITY Effects|nmod|high Effects|nmod|END_ENTITY	Effects of high versus low-dose atorvastatin on high sensitive C-reactive_protein in acute_coronary_syndrome .
21508802	0	atorvastatin	45,57	CD38	18,22	atorvastatin	CD38	MESH:C065179	952	Chemical	Gene	markers|nmod|START_ENTITY markers|nsubj|Downregulation Downregulation|nmod|activation activation|compound|END_ENTITY	Downregulation of CD38 activation markers by atorvastatin in HIV patients with undetectable viral load .
23686733	0	atorvastatin	16,28	CD38	50,54	atorvastatin	CD38	MESH:C065179	952	Chemical	Gene	activity|nmod|START_ENTITY activity|nmod|END_ENTITY	The activity of atorvastatin and rosiglitazone on CD38 , ZAP70 and apoptosis in lymphocytes of B-cell_chronic_lymphocytic_leukemia in vitro .
21297491	0	atorvastatin	15,27	CD4	31,34	atorvastatin	CD4	MESH:C065179	920	Chemical	Gene	START_ENTITY|nmod|CD25 CD25|compound|END_ENTITY	Effect of oral atorvastatin on CD4 + CD25 + regulatory T cells , FoxP3 expression , and prognosis in patients with ST-segment elevated myocardial_infarction before primary percutaneous coronary intervention .
12426205	0	atorvastatin	93,105	CD40	74,78	atorvastatin	CD40	MESH:C065179	958	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|expression expression|compound|END_ENTITY	3-hydroxy-3-methylglutaryl_coenzyme_A reductase-independent inhibition of CD40 expression by atorvastatin in human endothelial cells .
15276107	0	atorvastatin	10,22	CD40	44,48	atorvastatin	CD40	MESH:C065179	958	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effect of atorvastatin on the expression of CD40 ligand and P-selectin on platelets in patients with hypercholesterolemia .
15687128	0	atorvastatin	26,38	CD40	56,60	atorvastatin	CD40	MESH:C065179	958	Chemical	Gene	treatment|nmod|START_ENTITY reduces|nsubj|treatment reduces|dobj|ligand ligand|compound|END_ENTITY	Short-term treatment with atorvastatin reduces platelet CD40 ligand and thrombin generation in hypercholesterolemic patients .
17388962	0	atorvastatin	109,121	CD40	35,39	atorvastatin	CD40	MESH:C065179	958	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|dep|effect	Oxidative stress-mediated platelet CD40 ligand upregulation in patients with hypercholesterolemia : effect of atorvastatin .
19754853	0	atorvastatin	11,23	CD45	53,57	atorvastatin	CD45	MESH:C065179	5788	Chemical	Gene	START_ENTITY|acl|circulating circulating|dobj|END_ENTITY	Effects of atorvastatin on circulating CD34 + / CD133 + / CD45 - progenitor cells and indices of angiogenesis -LRB- vascular_endothelial_growth_factor and the angiopoietins 1 and 2 -RRB- in atherosclerotic vascular_disease and diabetes_mellitus .
26120010	0	atorvastatin	55,67	CYP3A	38,43	atorvastatin	CYP3A	MESH:C065179	1576	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nummod|END_ENTITY	Evaluation of the effects of the weak CYP3A inhibitors atorvastatin and ethinyl_estradiol / norgestimate on lomitapide pharmacokinetics in healthy subjects .
18528690	0	atorvastatin	69,81	CYP3A4	0,6	atorvastatin	CYP3A4	MESH:C065179	1576	Chemical	Gene	efficacy|nmod|START_ENTITY associated|nmod|efficacy associated|dep|END_ENTITY	CYP3A4 * 1G polymorphism is associated with lipid-lowering efficacy of atorvastatin but not of simvastatin .
23501331	0	atorvastatin	11,23	CYP3A4	27,33	atorvastatin	CYP3A4	MESH:C065179	1576	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of atorvastatin on CYP3A4 and CYP3A5 mRNA expression in mononuclear cells and CYP3A activity in hypercholeresterolemic patients .
24214373	0	atorvastatin	58,70	CYP3A4	14,20	atorvastatin	CYP3A4	MESH:C065179	1576	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY allele|nmod|pharmacokinetics allele|nsubj|effect effect|nmod|END_ENTITY	The effect of CYP3A4 * 1G allele on the pharmacokinetics of atorvastatin in Chinese Han patients with coronary_heart_disease .
19720407	0	atorvastatin	76,88	DKK1	10,14	atorvastatin	DKK1	MESH:C065179	22943	Chemical	Gene	Levels|nmod|START_ENTITY Levels|nmod|END_ENTITY	Levels of DKK1 in patients with acute_myocardial_infarction and response to atorvastatin .
18068977	0	atorvastatin	50,62	DPP-IV	39,45	atorvastatin	DPP-IV	MESH:C065179	1803	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of dipeptidyl_peptidase-IV -LRB- DPP-IV -RRB- by atorvastatin .
14662011	0	atorvastatin	43,55	E-selectin	81,91	atorvastatin	E-selectin	MESH:C065179	6401	Chemical	Gene	START_ENTITY|nmod|concentrations concentrations|nmod|diabetes_mellitus diabetes_mellitus|amod|END_ENTITY	Differential effects of fenofibrate versus atorvastatin on the concentrations of E-selectin and vascular cellular adhesion molecule-1 in patients with type 2 diabetes_mellitus and mixed_hyperlipoproteinemia : a randomized cross-over trial .
16060396	0	atorvastatin	40,52	E-selectin	56,66	atorvastatin	E-selectin	MESH:C065179	6401	Chemical	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	The effect of short-term treatment with atorvastatin on E-selectin levels in severely burned patients .
19201044	0	atorvastatin	178,190	EN-RAGE	132,139	atorvastatin	EN-RAGE	MESH:C065179	6283	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|dep|effects	C-reactive_protein -LRB- CRP -RRB- up-regulates expression of receptor_for_advanced_glycation_end_products -LRB- RAGE -RRB- and its inflammatory ligand EN-RAGE in THP-1 cells : inhibitory effects of atorvastatin .
21440631	0	atorvastatin	33,45	Endoglin	0,8	atorvastatin	Endoglin	MESH:C065179	13805(Tax:10090)	Chemical	Gene	treatment|compound|START_ENTITY marker|nmod|treatment END_ENTITY|nmod|marker	Endoglin as a possible marker of atorvastatin treatment benefit in atherosclerosis .
11165973	0	atorvastatin	44,56	Fibrinogen	0,10	atorvastatin	Fibrinogen	MESH:C065179	2244	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Fibrinogen response with simvastatin versus atorvastatin in familial_hypercholesterolemia .
15166393	0	atorvastatin	29,41	HMG-CoA_reductase	0,17	atorvastatin	HMG-CoA reductase	MESH:C065179	25675(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	HMG-CoA_reductase inhibitor , atorvastatin , promotes sensorimotor recovery , suppressing acute inflammatory reaction after experimental intracerebral_hemorrhage .
19227009	0	atorvastatin	48,60	HMG-CoA_reductase	78,95	atorvastatin	HMG-CoA reductase	MESH:C065179	15357(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Antitumor and apoptosis promoting properties of atorvastatin , an inhibitor of HMG-CoA_reductase , against Dalton 's _ Lymphoma_Ascites_tumor in mice .
25933963	0	atorvastatin	10,22	HMG-CoA_reductase	26,43	atorvastatin	HMG-CoA reductase	MESH:C065179	25675(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effect of atorvastatin , a HMG-CoA_reductase inhibitor in monosodium_iodoacetate-induced osteoarthritic_pain : Implication for osteoarthritis therapy .
8877677	0	atorvastatin	46,58	HMG-CoA_reductase	82,99	atorvastatin	HMG-CoA reductase	MESH:C065179	3156	Chemical	Gene	Tolerance|nmod|START_ENTITY Tolerance|appos|inhibitor inhibitor|nmod|END_ENTITY	Tolerance and pharmacokinetics of single-dose atorvastatin , a potent inhibitor of HMG-CoA_reductase , in healthy subjects .
8930429	0	atorvastatin	30,42	HMG-CoA_reductase	50,67	atorvastatin	HMG-CoA reductase	MESH:C065179	3156	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	The lipid-lowering effects of atorvastatin , a new HMG-CoA_reductase inhibitor : results of a randomized , double-masked study .
9485553	0	atorvastatin	117,129	HMG-CoA_reductase	62,79	atorvastatin	HMG-CoA reductase	MESH:C065179	25675(Tax:10116)	Chemical	Gene	quantitation|nmod|START_ENTITY assay|nmod|quantitation assay|amod|END_ENTITY	Development , validation , and interlaboratory comparison of an HMG-CoA_reductase inhibition assay for quantitation of atorvastatin in plasma matrices .
9520344	0	atorvastatin	63,75	HMG-CoA_reductase	35,52	atorvastatin	HMG-CoA reductase	MESH:C065179	25675(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|toxicity toxicity|nmod|inhibitor inhibitor|amod|END_ENTITY	Pre - and postnatal toxicity of the HMG-CoA_reductase inhibitor atorvastatin in rats .
17452168	0	atorvastatin	98,110	ICAM-1	9,15	atorvastatin	ICAM-1	MESH:C065179	3383	Chemical	Gene	treatment|compound|START_ENTITY diminished|nmod|treatment diminished|nsubjpass|END_ENTITY	Elevated ICAM-1 and MCP-1 plasma levels in subjects at high cardiovascular risk are diminished by atorvastatin treatment .
22609871	0	atorvastatin	11,23	ICAM-1	41,47	atorvastatin	ICAM-1	MESH:C065179	100009455(Tax:9986)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of atorvastatin on expression of ICAM-1 in atherosclerotic rabbits .
19275881	0	atorvastatin	10,22	IL-10	40,45	atorvastatin	IL-10	MESH:C065179	25325(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	Effect of atorvastatin on expression of IL-10 and TNF-alpha mRNA in myocardial ischemia-reperfusion_injury in rats .
11933922	0	atorvastatin	111,123	LDL-cholesterol	158,173	atorvastatin	LDL-cholesterol	MESH:C065179	22796	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	A randomized , double-blind , placebo-controlled , 8-week study to evaluate the efficacy and safety of once daily atorvastatin -LRB- 10 mg -RRB- in patients with elevated LDL-cholesterol .
16643923	0	atorvastatin	174,186	LDL-cholesterol	75,90	atorvastatin	LDL-cholesterol	MESH:C065179	22796	Chemical	Gene	stratified|amod|START_ENTITY study|amod|stratified targets|nmod|study starting|parataxis|targets starting|nmod|levels levels|amod|END_ENTITY	Effect of individualizing starting doses of a statin according to baseline LDL-cholesterol levels on achieving cholesterol targets : the achieve cholesterol targets fast with atorvastatin stratified titration -LRB- ACTFAST -RRB- study .
22810051	0	atorvastatin	66,78	MDR1	21,25	atorvastatin	MDR1	MESH:C065179	5243	Chemical	Gene	variation|acl|START_ENTITY variation|nmod|END_ENTITY	Genetic variation in MDR1 , LPL and eNOS genes and the response to atorvastatin treatment in ischemic_stroke .
21319376	0	atorvastatin	11,23	MMP-9	27,32	atorvastatin	MMP-9	MESH:C065179	81687(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	-LSB- Effect of atorvastatin on MMP-9 and TIMP-1 levels in bronchoalveolar lavage fluid and serum of rats with bleomycin-induced pulmonary_fibrosis -RSB- .
24386831	0	atorvastatin	43,55	MMP-9	67,72	atorvastatin	MMP-9	MESH:C065179	81687(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	-LSB- The effect of PPARalpha signal channel on atorvastatin inhibiting MMP-9 expression in aging myocytes -RSB- .
22615342	0	atorvastatin	49,61	Nox2	80,84	atorvastatin	Nox2	MESH:C065179	1536	Chemical	Gene	antioxidant|nmod|START_ENTITY antioxidant|nmod|END_ENTITY	Immediate antioxidant and antiplatelet effect of atorvastatin via inhibition of Nox2 .
24263084	0	atorvastatin	40,52	Nox2	56,60	atorvastatin	Nox2	MESH:C065179	1536	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|inhibition inhibition|amod|END_ENTITY	Antioxidant and antiplatelet effects of atorvastatin by Nox2 inhibition .
24434439	0	atorvastatin	20,32	PDCD4	59,64	atorvastatin	PDCD4	MESH:C065179	27250	Chemical	Gene	therapy|compound|START_ENTITY therapy|nmod|expression expression|compound|END_ENTITY	Effect of intensive atorvastatin therapy on periprocedural PDCD4 expression in CD4 + T lymphocytes of patients with unstable_angina undergoing percutaneous coronary intervention .
17643887	0	atorvastatin	79,91	PPAR-gamma	64,74	atorvastatin	PPAR-gamma	MESH:C065179	5468	Chemical	Gene	peroxisome_proliferator-activated_receptor-gamma|nmod|START_ENTITY peroxisome_proliferator-activated_receptor-gamma|appos|END_ENTITY	Activation of peroxisome_proliferator-activated_receptor-gamma -LRB- PPAR-gamma -RRB- by atorvastatin is mediated by 15-deoxy-delta-12 ,14 - PGJ2 .
23701370	0	atorvastatin	70,82	PPARa	0,5	atorvastatin	PPARa	MESH:C065179	19013(Tax:10090)	Chemical	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	PPARa is involved in the multitargeted effects of a pretreatment with atorvastatin in experimental stroke .
21796806	0	atorvastatin	11,23	RAGE	73,77	atorvastatin	RAGE	MESH:C065179	81722(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|progression progression|nmod|END_ENTITY	Effects of atorvastatin on progression of diabetic_nephropathy and local RAGE and soluble RAGE expressions in rats .
20064494	0	atorvastatin	99,111	SCARB1	13,19	atorvastatin	SCARB1	MESH:C065179	949	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|Influence Influence|nmod|polymorphisms polymorphisms|nummod|END_ENTITY	Influence of SCARB1 polymorphisms on serum lipids of hypercholesterolemic individuals treated with atorvastatin .
17473846	0	atorvastatin	69,81	SLCO1B1	21,28	atorvastatin	SLCO1B1	MESH:C065179	10599	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY polymorphism|nmod|pharmacokinetics polymorphism|nsubj|effects effects|nmod|END_ENTITY	Different effects of SLCO1B1 polymorphism on the pharmacokinetics of atorvastatin and rosuvastatin .
16185675	0	atorvastatin	10,22	SR-BI	26,31	atorvastatin	SR-BI	MESH:C065179	100009590(Tax:9986)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of atorvastatin on SR-BI expression and HDL-induced cholesterol efflux in adipocytes of hypercholesterolemic_rabbits .
22088250	0	atorvastatin	16,28	Toll-like_receptor_4	59,79	atorvastatin	Toll-like receptor 4	MESH:C065179	21898(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY -LSB-|dobj|effects -LSB-|nmod|expression expression|compound|END_ENTITY	-LSB- The effects of atorvastatin on C-reactive_protein induced Toll-like_receptor_4 expression on CD14 + monocyte -RSB- .
16386546	0	atorvastatin	23,35	adiponectin	39,50	atorvastatin	adiponectin	MESH:C065179	9370	Chemical	Gene	doses|nmod|START_ENTITY Effect|nmod|doses Effect|nmod|END_ENTITY	Effect of low doses of atorvastatin on adiponectin , glucose homeostasis , and clinical inflammatory markers in kidney transplant recipients .
18778396	0	atorvastatin	60,72	adiponectin	11,22	atorvastatin	adiponectin	MESH:C065179	9370	Chemical	Gene	multimer|xcomp|START_ENTITY multimer|nsubj|Changes Changes|nmod|END_ENTITY	Changes in adiponectin multimer distribution in response to atorvastatin treatment in patients with type 2 diabetes .
19210142	0	atorvastatin	68,80	adiponectin	15,26	atorvastatin	adiponectin	MESH:C065179	9370	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nmod|effect	Role of plasma adiponectin on the HDL-cholesterol raising effect of atorvastatin in patients with type 2 diabetes .
21748474	0	atorvastatin	11,23	apelin	27,33	atorvastatin	apelin	MESH:C065179	8862	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of atorvastatin on apelin , visfatin -LRB- nampt -RRB- , ghrelin and early carotid_atherosclerosis in patients with type 2 diabetes .
12235178	0	atorvastatin	10,22	apoE	33,37	atorvastatin	apoE	MESH:C065179	348	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of atorvastatin on plasma apoE metabolism in patients with combined_hyperlipidemia .
12460878	0	atorvastatin	10,22	apolipoprotein_A-I	51,69	atorvastatin	apolipoprotein A-I	MESH:C065179	100009253(Tax:9986)	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of atorvastatin on high-density lipoprotein apolipoprotein_A-I production and clearance in the New Zealand white rabbit .
17526934	0	atorvastatin	30,42	apolipoprotein_B-100	52,72	atorvastatin	apolipoprotein B-100	MESH:C065179	338	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of different doses of atorvastatin on human apolipoprotein_B-100 , B-48 , and A-I metabolism .
19200542	0	atorvastatin	21,33	apolipoprotein_B-48	64,83	atorvastatin	apolipoprotein B-48	MESH:C065179	338	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|amod|END_ENTITY	Effects of intensive atorvastatin and rosuvastatin treatment on apolipoprotein_B-48 and remnant lipoprotein cholesterol levels .
14564679	0	atorvastatin	10,22	apolipoprotein_B48	26,44	atorvastatin	apolipoprotein B48	MESH:C065179	338	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|metabolism metabolism|amod|END_ENTITY	Effect of atorvastatin on apolipoprotein_B48 metabolism and low-density_lipoprotein_receptor activity in normolipidemic patients with coronary_artery_disease .
12923226	0	atorvastatin	11,23	complement_component_3	52,74	atorvastatin	complement component 3	MESH:C065179	718	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|response response|amod|END_ENTITY	Effects of atorvastatin on fasting and postprandial complement_component_3 response in familial_combined_hyperlipidemia .
18068977	0	atorvastatin	50,62	dipeptidyl_peptidase-IV	14,37	atorvastatin	dipeptidyl peptidase-IV	MESH:C065179	1803	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of dipeptidyl_peptidase-IV -LRB- DPP-IV -RRB- by atorvastatin .
17901886	0	atorvastatin	115,127	endoglin	26,34	atorvastatin	endoglin	MESH:C065179	13805(Tax:10090)	Chemical	Gene	treatment|compound|START_ENTITY Endothelial|nmod|treatment Endothelial|dobj|expression expression|nmod|END_ENTITY	Endothelial expression of endoglin in normocholesterolemic and hypercholesterolemic C57BL/6J mice before and after atorvastatin treatment .
20156938	0	atorvastatin	38,50	endoglin	54,62	atorvastatin	endoglin	MESH:C065179	497010(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Mechanism of the inhibitory effect of atorvastatin on endoglin expression induced by transforming_growth_factor-beta1 in cultured cardiac fibroblasts .
16741040	0	atorvastatin	34,46	endothelin-1	57,69	atorvastatin	endothelin-1	MESH:C065179	1906	Chemical	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	The effects of different doses of atorvastatin on plasma endothelin-1 levels in type 2 diabetic patients with dyslipidemia .
11009276	0	atorvastatin	87,99	familial_hypercholesterolemia	103,132	atorvastatin	familial hypercholesterolemia	MESH:C065179	3949	Chemical	Gene	cholesterol|nmod|START_ENTITY cholesterol|nmod|END_ENTITY	High-density lipoprotein cholesterol and triglyceride response with simvastatin versus atorvastatin in familial_hypercholesterolemia .
16377918	0	atorvastatin	86,98	familial_hypercholesterolemia	128,157	atorvastatin	familial hypercholesterolemia	MESH:C065179	3949	Chemical	Gene	therapy|nmod|START_ENTITY therapy|nmod|END_ENTITY	Cross-over trial of intensive monotherapy with atorvastatin and combined therapy with atorvastatin and colestimide for Japanese familial_hypercholesterolemia .
10910028	0	atorvastatin	13,25	fibrinogen	48,58	atorvastatin	fibrinogen	MESH:C065179	2244	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|parameters parameters|compound|END_ENTITY	Influence of atorvastatin versus simvastatin on fibrinogen and other hemorheological parameters in patients with severe hypercholesterolemia treated with regular low-density lipoprotein immunoadsorption apheresis .
11078305	0	atorvastatin	10,22	fibrinogen	72,82	atorvastatin	fibrinogen	MESH:C065179	2244	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|compound|END_ENTITY	Effect of atorvastatin on hemorheologic-hemostatic_parameters and serum fibrinogen levels in hyperlipidemic patients .
9492781	0	atorvastatin	10,22	fibrinogen	33,43	atorvastatin	fibrinogen	MESH:C065179	2244	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of atorvastatin on plasma fibrinogen .
21806545	0	atorvastatin	38,50	leptin	54,60	atorvastatin	leptin	MESH:C065179	3952	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Mechanism of the inhibitory effect of atorvastatin on leptin expression induced by angiotensin_II in cultured human coronary artery smooth muscle cells .
17140582	1	atorvastatin	188,200	lipoprotein-associated_phospholipase_A2	130,169	atorvastatin	lipoprotein-associated phospholipase A2	MESH:C065179	7941	Chemical	Gene	treatment|compound|START_ENTITY Role|nmod|treatment Role|nmod|END_ENTITY	Role of the lipoprotein-associated_phospholipase_A2 and the effect of atorvastatin treatment .
24397933	0	atorvastatin	11,23	matrix_metalloproteinase-9	34,60	atorvastatin	matrix metalloproteinase-9	MESH:C065179	4318	Chemical	Gene	START_ENTITY|nmod|concentration concentration|amod|END_ENTITY	Effects of atorvastatin on plasma matrix_metalloproteinase-9 concentration after glial_tumor resection ; a randomized , double blind , placebo controlled trial .
19371267	0	atorvastatin	10,22	microRNA_221	26,38	atorvastatin	microRNA 221	MESH:C065179	407006	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of atorvastatin on microRNA_221 / 222 expression in endothelial progenitor cells obtained from patients with coronary_artery_disease .
12756509	0	atorvastatin	11,23	monocyte_chemoattractant_protein-1	65,99	atorvastatin	monocyte chemoattractant protein-1	MESH:C065179	6347	Chemical	Gene	simvastatin|compound|START_ENTITY Effects|nmod|simvastatin Effects|nmod|secretion secretion|amod|END_ENTITY	Effects of atorvastatin , simvastatin , and fenofibrate therapy on monocyte_chemoattractant_protein-1 secretion in patients with hyperlipidemia .
15772519	0	atorvastatin	18,30	monocyte_chemoattractant_protein-1	60,94	atorvastatin	monocyte chemoattractant protein-1	MESH:C065179	6347	Chemical	Gene	START_ENTITY|nmod|release release|amod|END_ENTITY	Effect of monthly atorvastatin and fenofibrate treatment on monocyte_chemoattractant_protein-1 release in patients with primary mixed_dyslipidemia .
16125534	0	atorvastatin	23,35	monocyte_chemoattractant_protein-1	51,85	atorvastatin	monocyte chemoattractant protein-1	MESH:C065179	6347	Chemical	Gene	START_ENTITY|acl|circulating circulating|dobj|diabetes diabetes|amod|END_ENTITY	The effect of low-dose atorvastatin on circulating monocyte_chemoattractant_protein-1 in patients with type 2 diabetes complicated by hyperlipidemia .
18167242	0	atorvastatin	14,26	monocyte_chemoattractant_protein-1	48,82	atorvastatin	monocyte chemoattractant protein-1	MESH:C065179	6347	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|expression expression|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Influence of atorvastatin on the expression of monocyte_chemoattractant_protein-1 in peritoneal mesothelial cells by high glucose -RSB- .
21924076	0	atorvastatin	11,23	monocyte_chemoattractant_protein-1	67,101	atorvastatin	monocyte chemoattractant protein-1	MESH:C065179	6347	Chemical	Gene	START_ENTITY|nmod|products products|acl|induced induced|dobj|expression expression|amod|END_ENTITY	-LSB- Effect of atorvastatin on advanced glycation end products induced monocyte_chemoattractant_protein-1 expression in cultured human endothelial cells -RSB- .
16480969	0	atorvastatin	14,26	myeloperoxidase	36,51	atorvastatin	myeloperoxidase	MESH:C065179	4353	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nsubj|effect	The effect of atorvastatin on serum myeloperoxidase and CRP levels in patients with acute_coronary_syndrome .
22129233	0	atorvastatin	7,19	myocardin	47,56	atorvastatin	myocardin	MESH:C065179	246297(Tax:10116)	Chemical	Gene	Use|nmod|START_ENTITY Use|xcomp|inhibit inhibit|dobj|expression expression|compound|END_ENTITY	Use of atorvastatin to inhibit hypoxia-induced myocardin expression .
21141556	0	atorvastatin	12,24	p27	28,31	atorvastatin	p27	MESH:C065179	83571(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effects of atorvastatin on p27 protein expression and cardiomyocytes apoptosis in spontaneously hypertensive rats -RSB- .
20818494	0	atorvastatin	15,27	p38	81,84	atorvastatin	p38	MESH:C065179	81649(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of atorvastatin on pulmonary_arterial_hypertension and expression of p38 , p27 , and Jab1 in rats .
19553142	0	atorvastatin	21,33	paraoxonase_1	37,50	atorvastatin	paraoxonase 1	MESH:C065179	5444	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Modulating effect of atorvastatin on paraoxonase_1 activity in type 2 diabetic Egyptian patients with or without nephropathy .
18093433	0	atorvastatin	12,24	peroxisome_proliferation_activated_receptor_gamma	42,91	atorvastatin	peroxisome proliferation activated receptor gamma	MESH:C065179	25664(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of atorvastatin on expression of peroxisome_proliferation_activated_receptor_gamma in unilateral_ureteral_obstruction in rats -RSB- .
16227702	0	atorvastatin	10,22	resistin	144,152	atorvastatin	resistin	MESH:C065179	56729	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|compound|END_ENTITY	Effect of atorvastatin on in vitro expression of resistin in adipocytes and monocytes/macrophages and effect of atorvastatin treatment on serum resistin levels in patients with type 2 diabetes .
16227702	0	atorvastatin	10,22	resistin	49,57	atorvastatin	resistin	MESH:C065179	56729	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of atorvastatin on in vitro expression of resistin in adipocytes and monocytes/macrophages and effect of atorvastatin treatment on serum resistin levels in patients with type 2 diabetes .
16227702	0	atorvastatin	112,124	resistin	144,152	atorvastatin	resistin	MESH:C065179	56729	Chemical	Gene	treatment|compound|START_ENTITY Effect|nmod|treatment Effect|nmod|levels levels|compound|END_ENTITY	Effect of atorvastatin on in vitro expression of resistin in adipocytes and monocytes/macrophages and effect of atorvastatin treatment on serum resistin levels in patients with type 2 diabetes .
16227702	0	atorvastatin	112,124	resistin	49,57	atorvastatin	resistin	MESH:C065179	56729	Chemical	Gene	treatment|compound|START_ENTITY Effect|nmod|treatment Effect|nmod|END_ENTITY	Effect of atorvastatin on in vitro expression of resistin in adipocytes and monocytes/macrophages and effect of atorvastatin treatment on serum resistin levels in patients with type 2 diabetes .
17942919	0	atorvastatin	77,89	tuberous_sclerosis_complex_2	34,62	atorvastatin	tuberous sclerosis complex 2	MESH:C065179	22084(Tax:10090)	Chemical	Gene	cells|nmod|START_ENTITY cells|amod|END_ENTITY	Selective inhibition of growth of tuberous_sclerosis_complex_2 null cells by atorvastatin is associated with impaired Rheb and Rho GTPase function and reduced mTOR/S6 kinase activity .
16044030	0	atorvastatin	10,22	tumor_necrosis_factor_alpha	26,53	atorvastatin	tumor necrosis factor alpha	MESH:C065179	100009088(Tax:9986)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|concentration concentration|compound|END_ENTITY	Effect of atorvastatin on tumor_necrosis_factor_alpha serum concentration and mRNA expression of adipose in hypercholesterolemic_rabbits .
19754853	0	atorvastatin	11,23	vascular_endothelial_growth_factor	105,139	atorvastatin	vascular endothelial growth factor	MESH:C065179	7422	Chemical	Gene	START_ENTITY|acl|circulating circulating|dobj|CD45 CD45|dep|cells cells|nmod|angiogenesis angiogenesis|dep|END_ENTITY	Effects of atorvastatin on circulating CD34 + / CD133 + / CD45 - progenitor cells and indices of angiogenesis -LRB- vascular_endothelial_growth_factor and the angiopoietins 1 and 2 -RRB- in atherosclerotic vascular_disease and diabetes_mellitus .
23646851	0	atorvastatin	121,133	vascular_endothelial_growth_factor	14,48	atorvastatin	vascular endothelial growth factor	MESH:C065179	83785(Tax:10116)	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|Assessment Assessment|nmod|metalloproteinase-9 metalloproteinase-9|compound|END_ENTITY	Assessment of vascular_endothelial_growth_factor and matrix metalloproteinase-9 in the periodontium of rats treated with atorvastatin .
19255896	0	atovaquone	42,52	apolipoprotein_E	12,28	atovaquone	apolipoprotein E	MESH:D053626	11816(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of apolipoprotein_E in uptake of atovaquone into the brain in murine acute and reactivated toxoplasmosis .
19883154	0	atovaquone	5,15	glucose-6-phosphate_dehydrogenase	95,128	atovaquone	glucose-6-phosphate dehydrogenase	MESH:D053626	2539	Chemical	Gene	START_ENTITY|nmod|patient patient|nmod|deficiency deficiency|amod|END_ENTITY	Oral atovaquone for the treatment of severe Pneumocystis_jirovecii_pneumonia in a patient with glucose-6-phosphate_dehydrogenase deficiency .
23035604	0	atoxil	11,17	C-reactive_protein	67,85	atoxil	C-reactive protein	null	1401	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of atoxil and triglobulin on cytokine balance and level of C-reactive_protein upon treatment of children with serious forms of bacterial_infections -RSB- .
22863933	0	atractylenolides	43,59	Sonic_Hedgehog	17,31	atractylenolides	Sonic Hedgehog	null	6469	Chemical	Gene	pathway|nmod|START_ENTITY pathway|compound|END_ENTITY	Targeting of the Sonic_Hedgehog pathway by atractylenolides promotes chondrogenic differentiation of mesenchymal stem cells .
16702986	0	atrasentan	28,38	endothelin-A_receptor	43,64	atrasentan	endothelin-A receptor	MESH:C430623	13617(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Cardioprotective effects of atrasentan , an endothelin-A_receptor antagonist , but not of nitric_oxide in diabetic mice with myocyte-specific overexpression of endothelial_nitric_oxide_synthase .
15901915	0	atrazine	11,19	CYP19	23,28	atrazine	CYP19	MESH:D001280	373656(Tax:8355)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effects of atrazine on CYP19 gene expression and aromatase activity in testes and on plasma sex steroid concentrations of male African_clawed_frogs -LRB- Xenopus_laevis -RRB- .
23583632	0	atrazine	43,51	LHR	77,80	atrazine	LHR	MESH:D001280	25477(Tax:10116)	Chemical	Gene	action|amod|START_ENTITY action|nmod|END_ENTITY	Involvement of ERK1/2 signaling pathway in atrazine action on FSH-stimulated LHR and CYP19A1 expression in rat granulosa cells .
21782617	0	atrazine	91,99	P-glycoprotein	13,27	atrazine	P-glycoprotein	MESH:D001280	287115(Tax:10116)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of P-glycoprotein , glutathione-S-transferase and cytochrome_P450 in rat liver by atrazine .
25138046	0	atrazine	10,18	corticosterone-binding-globulin	99,130	atrazine	corticosterone-binding-globulin	MESH:D001280	866	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of atrazine and fenitrothion at no-observed-effect-levels -LRB- NOEL -RRB- on amphibian and mammalian corticosterone-binding-globulin -LRB- CBG -RRB- .
19647285	0	atrazine	11,19	cytochrome_P450	23,38	atrazine	cytochrome P450	MESH:D001280	561462(Tax:7955)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|enzymes enzymes|amod|END_ENTITY	Effects of atrazine on cytochrome_P450 enzymes of zebrafish -LRB- Danio_rerio -RRB- .
9711812	0	atrazine	48,56	cytochrome_P450	21,36	atrazine	cytochrome P450	MESH:D001280	25251(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY liver|nmod|treatment liver|dobj|enzymes enzymes|amod|END_ENTITY	Changes in rat liver cytochrome_P450 enzymes by atrazine and simazine treatment .
8421084	0	atropine	56,64	GH	116,118	atropine	GH	MESH:D001285	2688	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Effect of growth_hormone -LRB- GH -RRB- - releasing hormone -LRB- GHRH -RRB- , atropine , pyridostigmine , or hypoglycemia on GHRP-6-induced GH secretion in man .
8421084	0	atropine	56,64	GH	26,28	atropine	GH	MESH:D001285	2688	Chemical	Gene	hormone|appos|START_ENTITY Effect|dep|hormone Effect|nmod|growth_hormone growth_hormone|appos|END_ENTITY	Effect of growth_hormone -LRB- GH -RRB- - releasing hormone -LRB- GHRH -RRB- , atropine , pyridostigmine , or hypoglycemia on GHRP-6-induced GH secretion in man .
16435472	0	atropine	14,22	GIP	65,68	atropine	GIP	MESH:D001285	2695	Chemical	Gene	polypeptide|amod|START_ENTITY polypeptide|appos|END_ENTITY	The effect of atropine on plasma gastric inhibitory polypeptide -LRB- GIP -RRB- , serum insulin , and blood glucose after intraduodenal infusion of fat .
7031846	0	atropine	60,68	GIP	79,82	atropine	GIP	MESH:D001285	2695	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of insulin-induced hypoglycemia with and without atropine on plasma GIP in man .
752033	0	atropine	10,18	GIP	82,85	atropine	GIP	MESH:D001285	2695	Chemical	Gene	START_ENTITY|nmod|gastrin gastrin|appos|END_ENTITY	Effect of atropine on meal-stimulated gastrin and gastric inhibitory polypeptide -LRB- GIP -RRB- release .
11716582	0	atropine	129,137	Prolactin	0,9	atropine	Prolactin	MESH:D001285	24683(Tax:10116)	Chemical	Gene	submitted|nmod|START_ENTITY submitted|nsubj|release release|compound|END_ENTITY	Prolactin release during exercise in normal and adrenodemedullated untrained rats submitted to central cholinergic blockade with atropine .
1683164	0	atropine	11,19	cholecystokinin	59,74	atropine	cholecystokinin	MESH:D001285	25298(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|response response|nmod|END_ENTITY	Effects of atropine on pancreatic response to bethanechol , cholecystokinin , and food intake in rats .
6724165	0	atropine	10,18	cholecystokinin	33,48	atropine	cholecystokinin	MESH:D001285	885	Chemical	Gene	START_ENTITY|nmod|response response|compound|END_ENTITY	Effect of atropine on the plasma cholecystokinin response to intraduodenal fat in man .
235785	0	atropine	14,22	gastric_intrinsic_factor	56,80	atropine	gastric intrinsic factor	MESH:D001285	2694	Chemical	Gene	START_ENTITY|nmod|secretion secretion|nmod|END_ENTITY	The effect of atropine and vagotomy on the secretion of gastric_intrinsic_factor -LRB- IF -RRB- in man .
1269867	0	atropine	15,23	gastrin	35,42	atropine	gastrin	MESH:D001285	100685087	Chemical	Gene	suppresses|compound|START_ENTITY release|nmod|suppresses release|nsubj|END_ENTITY	After vagotomy atropine suppresses gastrin release by food .
2868496	0	atropine	10,18	gastrin	29,36	atropine	gastrin	MESH:D001285	2520	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of atropine on plasma gastrin and somatostatin concentrations during sham feeding in man .
2885900	0	atropine	10,18	gastrin	66,73	atropine	gastrin	MESH:D001285	2520	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of atropine and somatostatin on bombesin-stimulated plasma gastrin , cholecystokinin and pancreatic polypeptide in man .
429555	0	atropine	10,18	gastrin	39,46	atropine	gastrin	MESH:D001285	2520	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of atropine on vagal release of gastrin and pancreatic_polypeptide .
4851606	0	atropine	10,18	gastrin	22,29	atropine	gastrin	MESH:D001285	2520	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|response response|compound|END_ENTITY	Effect of atropine on gastrin and gastric acid response to peptone meal .
6647889	0	atropine	14,22	gastrin	76,83	atropine	gastrin	MESH:D001285	2520	Chemical	Gene	effect|nmod|START_ENTITY stimulated|nsubj|effect stimulated|dobj|release release|compound|END_ENTITY	The effect of atropine on bombesin and gastrin_releasing_peptide stimulated gastrin , pancreatic_polypeptide and neurotensin release in man .
6719446	0	atropine	54,62	gastrin	7,14	atropine	gastrin	MESH:D001285	2520	Chemical	Gene	feeding|compound|START_ENTITY response|nmod|feeding END_ENTITY|dobj|response	Plasma gastrin and pancreatic_polypeptide response to atropine and sham feeding in man .
6886352	0	atropine	10,18	gastrin	65,72	atropine	gastrin	MESH:D001285	2520	Chemical	Gene	endoscopy|compound|START_ENTITY Effect|nmod|endoscopy Effect|nmod|END_ENTITY	Effect of atropine and upper gastrointestinal endoscopy on serum gastrin .
7353763	0	atropine	97,105	gastrin	43,50	atropine	gastrin	MESH:D001285	2520	Chemical	Gene	effect|nmod|START_ENTITY inhibition|dep|effect inhibition|nmod|release release|compound|END_ENTITY	Acid inhibition of sham feeding-stimulated gastrin release and gastric_acid secretion : effect of atropine .
897855	0	atropine	10,18	gastrin	47,54	atropine	gastrin	MESH:D001285	2520	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|response response|compound|END_ENTITY	Effect of atropine and metoclopramide on serum gastrin response to protein in patients with duodenal ulcers .
2504552	0	atropine	22,30	growth_hormone	34,48	atropine	growth hormone	MESH:D001285	2688	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|release release|amod|END_ENTITY	Inhibitory effects of atropine on growth_hormone release in normal subjects and acromegaly .
3987069	0	atropine	56,64	growth_hormone	28,42	atropine	growth hormone	MESH:D001285	2688	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of physiological growth_hormone secretion by atropine .
8421084	0	atropine	56,64	growth_hormone	10,24	atropine	growth hormone	MESH:D001285	2688	Chemical	Gene	hormone|appos|START_ENTITY Effect|dep|hormone Effect|nmod|END_ENTITY	Effect of growth_hormone -LRB- GH -RRB- - releasing hormone -LRB- GHRH -RRB- , atropine , pyridostigmine , or hypoglycemia on GHRP-6-induced GH secretion in man .
1175535	2	atropine	155,163	insulin	130,137	atropine	insulin	MESH:D001285	483665(Tax:9615)	Chemical	Gene	-RSB-|amod|START_ENTITY increase|nmod|-RSB- increase|nsubj|Inhibition Inhibition|nmod|phase phase|nmod|END_ENTITY	Inhibition of the early reflectoric phase of plasma insulin increase through atropine -RSB- .
3301456	0	atropine	10,18	insulin	22,29	atropine	insulin	MESH:D001285	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of atropine on insulin secretion in healthy subjects .
6993387	1	atropine	57,65	insulin	76,83	atropine	insulin	MESH:D001285	3630	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	V. Effects of atropine on plasma insulin .
8744976	0	atropine	61,69	insulin	13,20	atropine	insulin	MESH:D001285	3630	Chemical	Gene	blockade|nmod|START_ENTITY Induction|nmod|blockade Induction|nmod|resistance resistance|compound|END_ENTITY	Induction of insulin resistance by cholinergic blockade with atropine in the cat .
9241590	0	atropine	10,18	milk	22,26	atropine	milk	MESH:D001285	100532204	Chemical	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	Effect of atropine on milk protein yield by dairy cows with different beta-lactoglobulin phenotypes .
696866	0	atropine	10,18	pancreatic_polypeptide	35,57	atropine	pancreatic polypeptide	MESH:D001285	490944(Tax:9615)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|response response|amod|END_ENTITY	Effect of atropine and vagotomy on pancreatic_polypeptide response to a meal in dogs .
6778491	0	atropine	23,31	prolactin	41,50	atropine	prolactin	MESH:D001285	5617	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	-LSB- Inhibitory effects of atropine on serum prolactin levels after TRH stimulation -RSB- .
6669945	0	atropine	10,18	secretin	96,104	atropine	secretin	MESH:D001285	483407(Tax:9615)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of atropine on pancreatic bicarbonate output and plasma concentrations of immunoreactive secretin in response to intraduodenal stimulants .
7091334	0	atropine	11,19	secretin	49,57	atropine	secretin	MESH:D001285	6343	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|action action|nmod|END_ENTITY	Effects of atropine on the action and release of secretin in humans .
6675173	0	atropine	60,68	vasoactive_intestinal_polypeptide	79,112	atropine	vasoactive intestinal polypeptide	MESH:D001285	7432	Chemical	Gene	hypoglycemia|nmod|START_ENTITY effect|nmod|hypoglycemia END_ENTITY|nsubj|effect	The effect of insulin-induced hypoglycemia with and without atropine on plasma vasoactive_intestinal_polypeptide in man .
7134868	0	atropine	14,22	vasoactive_intestinal_polypeptide	33,66	atropine	vasoactive intestinal polypeptide	MESH:D001285	7432	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nsubj|effect	The effect of atropine on plasma vasoactive_intestinal_polypeptide after intraduodenal infusion of fat in man .
7711297	0	atropine	160,168	vasoactive_intestinal_polypeptide	107,140	atropine	vasoactive intestinal polypeptide	MESH:D001285	117064(Tax:10116)	Chemical	Gene	interactions|nmod|START_ENTITY activity|dep|interactions activity|nmod|kinase kinase|nmod|homogenates homogenates|nmod|lobes lobes|acl|incubated incubated|advcl|vitro vitro|nmod|presence presence|nmod|END_ENTITY	The activity of thymidine kinase in homogenates of rat thyroid lobes incubated in vitro in the presence of vasoactive_intestinal_polypeptide ; interactions with atropine and carbachol .
20542334	0	auranofin	18,27	STAT3	110,115	auranofin	STAT3	MESH:D001310	6774	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|down-regulation down-regulation|nmod|END_ENTITY	The gold compound auranofin induces apoptosis of human multiple myeloma cells through both down-regulation of STAT3 and inhibition of NF-kB activity .
23351386	0	auranofin	45,54	STAT3	77,82	auranofin	STAT3	MESH:D001310	6774	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Antiproliferative effect of gold -LRB- I -RRB- compound auranofin through inhibition of STAT3 and telomerase activity in MDA-MB 231 human breast_cancer cells .
23183361	0	auranofin	76,85	glutathione-S-transferase	36,61	auranofin	glutathione-S-transferase	MESH:D001310	373156	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	A new target for gold -LRB- I -RRB- compounds : glutathione-S-transferase inhibition by auranofin .
3142038	0	auranofin	10,19	interleukin-1	49,62	auranofin	interleukin-1	MESH:D001310	3552	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|production production|amod|END_ENTITY	Effect of auranofin and sodium_aurothiomalate on interleukin-1 production from human monocytes in vitro .
8668135	0	aureobasidin	30,42	AUR1	0,4	aureobasidin	AUR1	null	853866(Tax:4932)	Chemical	Gene	resistance|compound|START_ENTITY conferring|dobj|resistance gene|acl|conferring END_ENTITY|appos|gene	AUR1 , a novel gene conferring aureobasidin resistance on Saccharomyces_cerevisiae : a study of defective morphologies in Aur1p-depleted cells .
11418122	0	aureusidin	68,78	polyphenol_oxidase	91,109	aureusidin	polyphenol oxidase	MESH:C416232	5498	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Specificity analysis and mechanism of aurone synthesis catalyzed by aureusidin synthase , a polyphenol_oxidase homolog responsible for flower coloration .
21400516	0	aurintricarboxylic_acid	55,78	c-Met	24,29	aurintricarboxylic acid	c-Met	MESH:D001312	4233	Chemical	Gene	START_ENTITY|nsubj|inhibition inhibition|nmod|END_ENTITY	Anomalous inhibition of c-Met by the kinesin inhibitor aurintricarboxylic_acid .
4021478	0	aurintricarboxylic_acid	68,91	progesterone_receptor	29,50	aurintricarboxylic acid	progesterone receptor	MESH:D001312	396198(Tax:9031)	Chemical	Gene	START_ENTITY|nsubj|Interaction Interaction|nmod|END_ENTITY	Interaction of chick oviduct progesterone_receptor with immobilized aurintricarboxylic_acid .
2481441	0	aurintricarboxylic_acid	62,85	ribonuclease_inhibitor	39,61	aurintricarboxylic acid	ribonuclease inhibitor	MESH:D001312	641544(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Characterization Characterization|nmod|END_ENTITY	Characterization and use of the potent ribonuclease_inhibitor aurintricarboxylic_acid for the isolation of RNA from animal tissues .
9084414	0	aurintricarboxylic_acid	69,92	serotonin_transporter	6,27	aurintricarboxylic acid	serotonin transporter	MESH:D001312	6532	Chemical	Gene	regulation|nmod|START_ENTITY END_ENTITY|dep|regulation	Human serotonin_transporter : regulation by the neuroprotective agent aurintricarboxylic_acid and by epidermal_growth_factor .
3138383	0	aurothioglucose	18,33	catalase	62,70	aurothioglucose	catalase	MESH:D006051	24248(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY Effect|nmod|treatment END_ENTITY|nsubj|Effect	Effect of chronic aurothioglucose treatment of rats on kidney catalase and cytochromes .
22977847	0	aurothiomalate	26,40	NF-kB	10,15	aurothiomalate	NF-kB	MESH:D006052	443119(Tax:9940)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|inhibitor inhibitor|amod|END_ENTITY	Effect of NF-kB inhibitor aurothiomalate on local_inflammation in experimental Th1 - and Th2-type immune response .
23962904	0	aurothiomalate	53,67	PKC	37,40	aurothiomalate	PKC	MESH:D006052	5584	Chemical	Gene	START_ENTITY|nsubj|study study|nmod|inhibitor inhibitor|compound|END_ENTITY	Phase I dose escalation study of the PKC inhibitor aurothiomalate for advanced_non-small-cell_lung_cancer , ovarian_cancer , and pancreatic_cancer .
22759639	0	avanafil	15,23	PDE5	27,31	avanafil	PDE5	MESH:C553414	8654	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Selectivity of avanafil , a PDE5 inhibitor for the treatment of erectile_dysfunction : implications for clinical safety and improved tolerability .
26620317	0	avermectin	47,57	FXR	40,43	avermectin	FXR	MESH:C019264	9971	Chemical	Gene	analogues|compound|START_ENTITY END_ENTITY|nmod|analogues	Selective targeting of nuclear receptor FXR by avermectin analogues with therapeutic effects on nonalcoholic_fatty_liver_disease .
17354009	0	avermectin	60,70	p-glycoprotein	27,41	avermectin	p-glycoprotein	MESH:C019264	5243	Chemical	Gene	toxicity|compound|START_ENTITY polymorphisms|nmod|toxicity polymorphisms|nsubj|impact impact|appos|END_ENTITY	Potential impact of ABCB1 -LRB- p-glycoprotein -RRB- polymorphisms on avermectin toxicity in humans .
20868619	0	avotermin	11,20	transforming_growth_factor_b3	22,51	avotermin	transforming growth factor b3	MESH:C509044	397400(Tax:9823)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of avotermin -LRB- transforming_growth_factor_b3 -RRB- in a clinically relevant pig model of long , full-thickness incisional wounds .
24462920	0	axitinib	26,34	CYP1A2	66,72	axitinib	CYP1A2	MESH:C503983	1544	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	The multikinase inhibitor axitinib is a potent inhibitor of human CYP1A2 .
23345001	0	axitinib	39,47	VEGF	57,61	axitinib	VEGF	MESH:C503983	7422	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	The risk of hand-foot skin reaction to axitinib , a novel VEGF inhibitor : a systematic review of literature and meta-analysis .
26709219	0	aza-anthrapyrazole	3,21	Th1	43,46	aza-anthrapyrazole	Th1	null	51497	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	An aza-anthrapyrazole negatively regulates Th1 activity and suppresses experimental_autoimmune_encephalomyelitis .
6525354	0	aza-ellipticine	43,58	BD-40	11,16	aza-ellipticine	BD-40	null	360217(Tax:10090)	Chemical	Gene	Effects|dep|START_ENTITY Effects|nmod|END_ENTITY	Effects of BD-40 , an ellipticine analogue -LRB- aza-ellipticine -RRB- on cell cycle traverse and DNA synthesis in cultures of synchronized mouse fibroblasts .
11351403	0	azaarenes	72,81	Cytochrome_P450	0,15	azaarenes	Cytochrome P450	CHEBI:50893	4051	Chemical	Gene	induction|nmod|START_ENTITY induction|nsubj|END_ENTITY	Cytochrome_P450 induction by nitrated_polycyclic_aromatic_hydrocarbons , azaarenes , and binary mixtures in fish hepatoma cell line PLHC-1 .
8043036	0	azabicyclo-naphthyridone	54,78	CP-99	35,40	azabicyclo-naphthyridone	CP-99	null	13917311	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	In vitro antimicrobial activity of CP-99 ,219 , a novel azabicyclo-naphthyridone .
22230298	0	azacitidine	134,145	DNMT	118,122	azacitidine	DNMT	MESH:D001374	1786	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Proteomic analysis identifies differentially expressed proteins in AML1/ETO acute myeloid_leukemia cells treated with DNMT inhibitors azacitidine and decitabine .
22399596	0	azacitidine	43,54	SKM-1	108,113	azacitidine	SKM-1	MESH:D001374	6329	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Antiproliferative and antitumor effects of azacitidine against the human myelodysplastic_syndrome cell line SKM-1 .
20119716	0	azacitidine	77,88	cytochrome_P450	23,38	azacitidine	cytochrome P450	MESH:D001374	4051	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	In vitro assessment of cytochrome_P450 inhibition and induction potential of azacitidine .
23085464	0	azacitidine	11,22	matrix_metalloproteinase-9	26,52	azacitidine	matrix metalloproteinase-9	MESH:D001374	4318	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of azacitidine on matrix_metalloproteinase-9 in acute_myeloid_leukemia and myelodysplasia .
17727872	0	azacryptand	47,58	SERS	85,89	azacryptand	SERS	MESH:C525617	54938	Chemical	Gene	using|dobj|START_ENTITY using|nmod|END_ENTITY	One-step synthesis of gold nanoparticles using azacryptand and their applications in SERS and catalysis .
12543079	0	azacytidine	10,21	leukemia_inhibitory_factor	40,66	azacytidine	leukemia inhibitory factor	MESH:D001374	3976	Chemical	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	Effect of azacytidine in the release of leukemia_inhibitory_factor , oncostatin_m , interleukin _ -LRB- IL -RRB- -6 , and IL-11 by mononuclear cells of patients with refractory_anemia .
17765967	0	azadirachtin	10,22	acetylcholinesterase	26,46	azadirachtin	acetylcholinesterase	MESH:C010329	43	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	Effect of azadirachtin on acetylcholinesterase -LRB- AChE -RRB- activity and histology of the brown_planthopper_Nilaparvata lugens -LRB- St l -RRB- .
2900005	0	azadirachtin	11,23	ecdysone_20-monooxygenase	61,86	azadirachtin	ecdysone 20-monooxygenase	MESH:C010329	39592(Tax:7227)	Chemical	Gene	Effects|nmod|START_ENTITY cytochrome|nsubj|Effects cytochrome|dobj|activity activity|amod|END_ENTITY	Effects of azadirachtin on insect cytochrome P-450 dependent ecdysone_20-monooxygenase activity .
9131784	0	azadirachtin	35,47	ecdysone_20-monooxygenase	92,117	azadirachtin	ecdysone 20-monooxygenase	MESH:C010329	39592(Tax:7227)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effects of the neem tree compounds azadirachtin , salannin , nimbin , and 6-desacetylnimbin on ecdysone_20-monooxygenase activity .
1674753	0	azapeptides	60,71	dipeptidylpeptidase_IV	12,34	azapeptides	dipeptidylpeptidase IV	null	1803	Chemical	Gene	Reaction|nmod|START_ENTITY Reaction|nmod|END_ENTITY	Reaction of dipeptidylpeptidase_IV with substrate-analogous azapeptides .
11593985	0	azaphenylalanine	31,47	thrombin	6,14	azaphenylalanine	thrombin	null	2147	Chemical	Gene	inhibitors|nmod|START_ENTITY inhibitors|compound|END_ENTITY	Novel thrombin inhibitors with azaphenylalanine scaffold .
10344570	0	azaphilones	71,82	cholesteryl_ester_transfer_protein	33,67	azaphilones	cholesteryl ester transfer protein	CHEBI:50941	1071	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Structure-specific inhibition of cholesteryl_ester_transfer_protein by azaphilones .
23551924	0	azapirone	45,54	5-HT1A_receptor	55,70	azapirone	5-HT1A receptor	null	3350	Chemical	Gene	agonists|amod|START_ENTITY agonists|amod|END_ENTITY	Augmentation of antipsychotic drug action by azapirone 5-HT1A_receptor partial agonists : a meta-analysis .
23950142	0	azathioprine	23,35	Rac1	87,91	azathioprine	Rac1	MESH:D001379	19353(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|nmod|inhibition inhibition|nmod|END_ENTITY	Immunosuppressive drug azathioprine reduces aneurysm progression through inhibition of Rac1 and c-Jun-terminal-N-kinase in endothelial cells .
23075721	0	azathioprine	126,138	Thiopurine_methyltransferase	0,28	azathioprine	Thiopurine methyltransferase	MESH:D001379	7172	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|polymorphisms polymorphisms|amod|END_ENTITY	Thiopurine_methyltransferase gene polymorphisms and activity in Chinese patients with inflammatory_bowel_disease treated with azathioprine .
3920961	0	azathioprine	26,38	interferon-gamma	60,76	azathioprine	interferon-gamma	MESH:D001379	3458	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|production production|amod|END_ENTITY	Effects of treatment with azathioprine and cyclosporin_A on interferon-gamma production by peripheral blood leukocytes of renal allograft recipients .
2931095	0	azathioprine	90,102	interleukin-2	10,23	azathioprine	interleukin-2	MESH:D001379	3558	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of interleukin-2 on the inhibition of the human mixed lymphocyte reaction -LRB- MLR -RRB- by azathioprine .
8165444	0	azathioprine	14,26	interleukin_6_and_soluble_interleukin_2_receptor	46,94	azathioprine	interleukin 6 and soluble interleukin 2 receptor	MESH:D001379	3569	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of azathioprine on serum levels of interleukin_6_and_soluble_interleukin_2_receptor .
1680533	0	azelastine	10,20	platelet-activating_factor	74,100	azelastine	platelet-activating factor	MESH:C020976	9768	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of azelastine and ketotifen on the bronchial and skin responses to platelet-activating_factor in humans .
24274229	0	azelastine	21,31	substance_P	35,46	azelastine	substance P	MESH:C020976	6863	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	Effect of intranasal azelastine on substance_P release in perennial_nonallergic_rhinitis patients .
7679943	0	azelastine	10,20	substance_P	24,35	azelastine	substance P	MESH:C020976	6863	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|content content|compound|END_ENTITY	Effect of azelastine on substance_P content in bronchoalveolar and nasal lavage fluids of patients with allergic_asthma .
8162343	0	azelastine	21,31	tumor_necrosis_factor-alpha	76,103	azelastine	tumor necrosis factor-alpha	MESH:C020976	7124	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Inhibitory effect of azelastine , a potent antiallergic agent , on release of tumor_necrosis_factor-alpha from activated human peripheral blood mononuclear cells and U937 cells .
9827354	0	azelastine	38,48	tumor_necrosis_factor-alpha	53,80	azelastine	tumor necrosis factor-alpha	MESH:C020976	21926(Tax:10090)	Chemical	Gene	agent|appos|START_ENTITY Influence|nmod|agent Influence|nmod|secretion secretion|amod|END_ENTITY	Influence of the anti-allergic agent , azelastine , on tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- secretion from cultured mouse mast cells .
10757040	0	azelastine_hydrochloride	23,47	CD40	51,55	azelastine hydrochloride	CD40	MESH:C020976	21939(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|compound|END_ENTITY	Suppressive effects of azelastine_hydrochloride on CD40 expression in mice .
9074948	0	azelastine_hydrochloride	15,39	NF-kappa_B	43,53	azelastine hydrochloride	NF-kappa B	MESH:C020976	4790	Chemical	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Suppression by azelastine_hydrochloride of NF-kappa_B activation involved in generation of cytokines and nitric_oxide .
23084905	0	azepinomycin	35,47	guanase	66,73	azepinomycin	guanase	MESH:C054358	9615	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Investigations into specificity of azepinomycin for inhibition of guanase : discrimination between the natural heterocyclic inhibitor and its synthetic nucleoside analogues .
21802292	0	azetidine	74,83	MCHR1	84,89	azetidine	MCHR1	MESH:C082735	2847	Chemical	Gene	START_ENTITY|dobj|antagonists antagonists|nummod|END_ENTITY	Strategies to lower the Pgp efflux liability in a series of potent indole azetidine MCHR1 antagonists .
19359193	0	azialcohol	22,32	PKCdelta	54,62	azialcohol	PKCdelta	null	5580	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Photoincorporation of azialcohol to the C1B domain of PKCdelta is buffer dependent .
23172365	0	azide	15,20	RNase_A	51,58	azide	RNase A	CHEBI:40910	6035	Chemical	Gene	incorporation|nsubj|START_ENTITY incorporation|nmod|END_ENTITY	Site-selective azide incorporation into endogenous RNase_A via a `` chemistry '' approach .
24807699	0	azide	93,98	SAMs	143,147	azide	SAMs	CHEBI:40910	4143	Chemical	Gene	reaction|amod|START_ENTITY reaction|nmod|END_ENTITY	Adjusting the surface areal density of click-reactive azide groups by kinetic control of the azide substitution reaction on bromine-functional SAMs .
16202884	0	azide	73,78	catalase	21,29	azide	catalase	CHEBI:40910	847	Chemical	Gene	determination|nmod|START_ENTITY based|nmod|determination based|nmod|END_ENTITY	A biosensor based on catalase for determination of highly toxic chemical azide in fruit juices .
5834245	0	azide	16,21	catalase	27,35	azide	catalase	CHEBI:40910	847	Chemical	Gene	reaction|nmod|START_ENTITY reaction|nmod|END_ENTITY	The reaction of azide with catalase and their significance .
2857551	0	azide	15,20	mitochondrial_ATPase	37,57	azide	mitochondrial ATPase	CHEBI:40910	514	Chemical	Gene	Interaction|nmod|START_ENTITY END_ENTITY|nsubj|Interaction	Interaction of azide with beef heart mitochondrial_ATPase .
2538428	0	azide	34,39	myoglobin	77,86	azide	myoglobin	CHEBI:40910	4151	Chemical	Gene	complex|compound|START_ENTITY complex|nmod|END_ENTITY	Single-crystal EPR study of novel azide complex of cyanogen bromide-modified myoglobin .
2231185	0	azidothymidine	10,24	CD4	36,39	azidothymidine	CD4	MESH:D015215	920	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|compound|END_ENTITY	Effect of azidothymidine on soluble CD4 levels in patients with AIDS or AIDS-related_complex .
21176536	0	azidothymidine	12,26	p33ING1b	30,38	azidothymidine	p33ING1b	MESH:D015215	3621	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|amod|END_ENTITY	-LSB- Effects of azidothymidine on p33ING1b expression , apoptosis and senescence of TJ905 human glioblastoma cell line -RSB- .
9237480	0	aziridinium	123,134	choline_acetyltransferase	64,89	aziridinium	choline acetyltransferase	CHEBI:50929	290567(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Brain-derived_neurotrophic_factor induced stimulation of septal choline_acetyltransferase activity in ethylcholine mustard aziridinium treated rats .
8043012	0	azole	64,69	microsomal_epoxide_hydrolase	27,55	azole	microsomal epoxide hydrolase	CHEBI:68452	25315(Tax:10116)	Chemical	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Differential expression of microsomal_epoxide_hydrolase gene by azole heterocycles in rats .
25466197	0	azoles	6,12	CB2	49,52	azoles	CB2	MESH:D001393	1269	Chemical	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	Novel azoles as potent and selective cannabinoid CB2 receptor agonists .
25544389	0	azoles	44,50	CYP2E1	54,60	azoles	CYP2E1	MESH:D001393	1571	Chemical	Gene	basis|nmod|START_ENTITY basis|nmod|END_ENTITY	Structural basis for cooperative binding of azoles to CYP2E1 as interpreted through guided molecular dynamics simulations .
10715163	0	azolidinediones	4,19	protein_tyrosine_phosphatase_1B	37,68	azolidinediones	protein tyrosine phosphatase 1B	null	5770	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	New azolidinediones as inhibitors of protein_tyrosine_phosphatase_1B with antihyperglycemic properties .
26386604	0	azolotriazinone	10,25	MCHR1	26,31	azolotriazinone	MCHR1	null	83567(Tax:10116)	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|compound|END_ENTITY	Non-basic azolotriazinone MCHR1 antagonists for the treatment of obesity : An empirical brain-exposures-driven candidate selection for in vivo efficacy studies .
6113965	0	azosemide	111,120	renin	14,19	azosemide	renin	MESH:C018222	5972	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|effect effect|nmod|END_ENTITY	The effect of renin and aldosterone inhibition by beta-adrenergic blockade on the response to the new diuretic azosemide .
7047325	0	azosemide	28,37	renin	146,151	azosemide	renin	MESH:C018222	24715(Tax:10116)	Chemical	Gene	-LSB-|amod|START_ENTITY studies|nmod|-LSB- studies|dep|-RSB- -RSB-|appos|-RSB- -RSB-|amod|diuretic diuretic|dep|Effects Effects|appos|activity activity|compound|END_ENTITY	-LSB- Pharmacological studies on azosemide -LSB- 5 - -LRB- 4 ' - chloro-5 ' - sulfamoyl-2 ' - thenylamino -RRB- - phenyltetrazole -RSB- , a new diuretic -LRB- 1 -RRB- Effects on diuresis , plasma renin activity and urinary prostaglandin_E excretion in normal rats -LRB- author 's transl -RRB- -RSB- .
2501972	0	azoxymethane	64,76	diamine_oxidase	36,51	azoxymethane	diamine oxidase	MESH:D001397	65029(Tax:10116)	Chemical	Gene	intestinal|nmod|START_ENTITY intestinal|dobj|activity activity|amod|END_ENTITY	Early alterations of rat intestinal diamine_oxidase activity by azoxymethane , an intestinal carcinogen .
10938397	0	azoxymethane	105,117	transforming_growth_factor_beta1	14,46	azoxymethane	transforming growth factor beta1	MESH:D001397	21803(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Expression Expression|nmod|END_ENTITY	Expression of transforming_growth_factor_beta1 and its type II receptor in mouse colon_tumors induced by azoxymethane .
9011117	0	aztreonam	94,103	granulocyte_colony-stimulating_factor	28,65	aztreonam	granulocyte colony-stimulating factor	MESH:D001398	1440	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of recombinant human granulocyte_colony-stimulating_factor on combination therapy with aztreonam and clindamycin for infections in neutropenic patients with hematologic_diseases .
20800053	0	azurin	19,25	p53	51,54	azurin	p53	null	7157	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	The interaction of azurin and C-terminal domain of p53 is mediated by nucleic acids .
8564520	0	azurophil	23,32	complement_receptor_type_1	70,96	azurophil	complement receptor type 1	null	1378	Chemical	Gene	down-regulation|amod|START_ENTITY down-regulation|nmod|END_ENTITY	Serum protects against azurophil granule dependent down-regulation of complement_receptor_type_1 -LRB- CR1 -RRB- on human neutrophils .
22848597	0	b,b-Dimethylacrylshikonin	0,25	ERK	75,78	b,b-Dimethylacrylshikonin	ERK	null	5594	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	b,b-Dimethylacrylshikonin induces mitochondria dependent apoptosis through ERK pathway in human gastric_cancer SGC-7901 cells .
25324544	0	b-Apo-13-carotenone	0,19	retinoid_X_receptor	30,49	b-Apo-13-carotenone	retinoid X receptor	null	6256	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	b-Apo-13-carotenone regulates retinoid_X_receptor transcriptional activity through tetramerization of the receptor .
22699970	0	b-Arrestin	0,10	ERK1/2	57,63	b-Arrestin	ERK1/2	null	5595;5594	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|nmod|END_ENTITY	b-Arrestin prevents cell apoptosis through pro-apoptotic ERK1/2 and p38 MAPKs and anti-apoptotic Akt pathways .
23839051	0	b-Arrestin-2	0,12	Akt	68,71	b-Arrestin-2	Akt	null	11651(Tax:10090)	Chemical	Gene	inhibits|dep|START_ENTITY inhibits|nsubj|END_ENTITY	b-Arrestin-2 inhibits preference for alcohol in mice and suppresses Akt signaling in the dorsal striatum .
23765383	0	b-Caryophyllene_oxide	0,21	STAT3	58,63	b-Caryophyllene oxide	STAT3	null	6774	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	b-Caryophyllene_oxide inhibits constitutive and inducible STAT3 signaling pathway through induction of the SHP-1 protein tyrosine phosphatase .
24473141	0	b-Conglycinin	0,13	occludin	41,49	b-Conglycinin	occludin	null	100506658	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	b-Conglycinin reduces the tight junction occludin and ZO-1 expression in IPEC-J2 .
26005541	0	b-Homophenylalanine	59,78	DPP-4	101,106	b-Homophenylalanine	DPP-4	null	13482(Tax:10090)	Chemical	Gene	Derivatives|amod|START_ENTITY Derivatives|nmod|Inhibitors Inhibitors|compound|END_ENTITY	Design , Synthesis , and Pharmacological Evaluation of Fused b-Homophenylalanine Derivatives as Potent DPP-4 Inhibitors .
24023520	0	b-Lapachone	36,47	IDO1	73,77	b-Lapachone	IDO1	null	3620	Chemical	Gene	Inhibitor|nsubj|START_ENTITY Inhibitor|nmod|END_ENTITY	The Tumor-Selective Cytotoxic Agent b-Lapachone is a Potent Inhibitor of IDO1 .
26496175	0	b-Lapachone	18,29	MALT1	47,52	b-Lapachone	MALT1	null	10892	Chemical	Gene	Analogs|amod|START_ENTITY Analogs|nmod|END_ENTITY	Identification of b-Lapachone Analogs as Novel MALT1 Inhibitors To Treat an Aggressive Subtype of Diffuse Large B-Cell_Lymphoma .
23746950	0	b-Lapachone	47,58	NQO1	112,116	b-Lapachone	NQO1	null	1728	Chemical	Gene	oxidoreductase|amod|START_ENTITY oxidoreductase|appos|END_ENTITY	Synergistic enhancement of antitumor effect of b-Lapachone by photodynamic induction of quinone oxidoreductase -LRB- NQO1 -RRB- .
23525626	0	b-Lapachone	0,11	heme_oxygenase-1	86,102	b-Lapachone	heme oxygenase-1	null	3162	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	b-Lapachone , a substrate of NAD -LRB- P -RRB- H : quinone oxidoreductase , induces anti-inflammatory heme_oxygenase-1 via AMP-activated_protein_kinase activation in RAW264 .7 macrophages .
24014020	0	b-N-acetylglucosamine	9,30	emerin	52,58	b-N-acetylglucosamine	emerin	null	2010	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	O-Linked b-N-acetylglucosamine -LRB- O-GlcNAc -RRB- regulates emerin binding to barrier_to_autointegration_factor -LRB- BAF -RRB- in a chromatin - and lamin B-enriched `` niche '' .
21323804	0	b-NAC	6,11	EGD1	0,4	b-NAC	EGD1	null	856070(Tax:4932)	Chemical	Gene	mRNA|dep|START_ENTITY mRNA|compound|END_ENTITY	EGD1 -LRB- b-NAC -RRB- mRNA is localized in a novel cytoplasmic structure in Saccharomyces_cerevisiae .
26725430	0	b-Naphthoflavone	11,27	Ugt1a6	31,37	b-Naphthoflavone	Ugt1a6	null	113992(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of b-Naphthoflavone on Ugt1a6 and Ugt1a7 Expression in Rat Brain .
22309674	0	b-Phenethyl_isothiocyanate	0,26	death_receptor_5	35,51	b-Phenethyl isothiocyanate	death receptor 5	null	8795	Chemical	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	b-Phenethyl_isothiocyanate induces death_receptor_5 to induce apoptosis in human oral_cancer cells via p38 .
24373881	0	b-carbolines	41,53	MAO	33,36	b-carbolines	MAO	null	29253(Tax:10116)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of monoamine_oxidase -LRB- MAO -RRB- by b-carbolines and their interactions in live neuronal -LRB- PC12 -RRB- and liver -LRB- HuH-7 and MH1C1 -RRB- cells .
24373881	0	b-carbolines	41,53	monoamine_oxidase	14,31	b-carbolines	monoamine oxidase	null	29253(Tax:10116)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of monoamine_oxidase -LRB- MAO -RRB- by b-carbolines and their interactions in live neuronal -LRB- PC12 -RRB- and liver -LRB- HuH-7 and MH1C1 -RRB- cells .
22469593	0	b-carotene	19,29	VEGF	61,65	b-carotene	VEGF	null	7422	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Diverse effects of b-carotene on secretion and expression of VEGF in human hepatocarcinoma and prostate_tumor cells .
25179573	8	b-caryophyllene	1478,1493	CB1	1497,1500	b-caryophyllene	CB1	null	25248(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	CB2_receptor blockade by AM630 prevents the effects of b-caryophyllene on CB1 receptor and MMP-1 genes expression .
22982537	0	b-damascenone	67,80	filaggrin	21,30	b-damascenone	filaggrin	null	14246(Tax:10090)	Chemical	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	A novel mechanism of filaggrin induction and sunburn prevention by b-damascenone in Skh-1 mice .
24146496	0	b-elemene	15,24	HIF-1A	52,58	b-elemene	HIF-1A	null	3091	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	The effects of b-elemene on the expression of mTOR , HIF-1A , survivin in lung_adenocarcinoma A549 cell .
22736026	0	b-elemene	18,27	HIF-1a	0,6	b-elemene	HIF-1a	null	3091	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	HIF-1a induced by b-elemene protects human osteosarcoma cells from undergoing apoptosis .
26379399	0	b-elemene	0,9	Pak1	78,82	b-elemene	Pak1	null	5058	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|advcl|inhibiting inhibiting|dobj|activation activation|amod|END_ENTITY	b-elemene enhances the radiosensitivity of gastric_cancer cells by inhibiting Pak1 activation .
21519795	0	b-elemene	0,9	glia_maturation_factor_b	87,111	b-elemene	glia maturation factor b	null	2764	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|activation activation|nmod|END_ENTITY	b-elemene inhibits proliferation of human glioblastoma cells through the activation of glia_maturation_factor_b and induces sensitization to cisplatin .
24146496	0	b-elemene	15,24	mTOR	46,50	b-elemene	mTOR	null	21977(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	The effects of b-elemene on the expression of mTOR , HIF-1A , survivin in lung_adenocarcinoma A549 cell .
23510298	0	b-galactoside	54,67	galectin-1	94,104	b-galactoside	galectin-1	null	3956	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Involvement of histidine residues in the pH-dependent b-galactoside binding activity of human galectin-1 .
22485126	0	b-glucogallin	38,51	aldose_reductase	63,79	b-glucogallin	aldose reductase	null	231	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|compound|END_ENTITY	The isolation and characterization of b-glucogallin as a novel aldose_reductase inhibitor from Emblica officinalis .
21172735	0	b-hematin	41,50	MetHb	95,100	b-hematin	MetHb	null	3048	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Synthesis , antiprotozoal , antimicrobial , b-hematin inhibition , cytotoxicity and methemoglobin -LRB- MetHb -RRB- formation activities of bis -LRB- 8-aminoquinolines -RRB- .
25580562	0	b-hydroxybutyric_acid	0,21	growth_hormone-releasing_hormone	31,63	b-hydroxybutyric acid	growth hormone-releasing hormone	null	29446(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|synthesis synthesis|amod|END_ENTITY	b-hydroxybutyric_acid inhibits growth_hormone-releasing_hormone synthesis and secretion through the GPR109A/ERK1/2 signaling pathway in the hypothalamus .
23216634	0	b-lapachone	11,22	Th1	44,47	b-lapachone	Th1	null	57314(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	Effects of b-lapachone on the production of Th1 and Th2 cytokines in C57BL/6 mice .
26718788	0	b-lapachone	0,11	specificity_protein_1	88,109	b-lapachone	specificity protein 1	null	6667	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	b-lapachone suppresses the proliferation of human malignant_melanoma cells by targeting specificity_protein_1 .
22889553	0	b-naphthoflavone	51,67	CYP1A1	31,37	b-naphthoflavone	CYP1A1	null	403103(Tax:9823)	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression and inducibility of CYP1A1 , 1A2 , 1B1 by b-naphthoflavone and CYP2B22 , CYP3As by rifampicin in heart regions and coronary arteries of pig .
25215095	0	b-sodium_aescinate	10,28	hypoxia-inducible_factor-1a	32,59	b-sodium aescinate	hypoxia-inducible factor-1a	null	29560(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of b-sodium_aescinate on hypoxia-inducible_factor-1a expression in rat brain cortex after cardiopulmonary resuscitation .
22419431	0	b-thujaplicin	22,35	MMP-1	56,61	b-thujaplicin	MMP-1	null	4312	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Preventive effects of b-thujaplicin against UVB-induced MMP-1 and MMP-3 mRNA expressions in skin fibroblasts .
14611344	0	b3IIu	107,112	Rb2	129,132	b3IIu	Rb2	null	5934	Chemical	Gene	system|amod|START_ENTITY system|nmod|END_ENTITY	Bound-bound state quantum wave packet dynamics in the intermediate coupling range : the A1Sigma + u -LRB- 0 + u -RRB- and b3IIu -LRB- 0 + u -RRB- system in Rb2 .
10429657	8	bFGF	1298,1302	ETS-1	1354,1359	bFGF	ETS-1	null	23871(Tax:10090)	Chemical	Gene	induced|nsubj|START_ENTITY induced|dobj|expression expression|nmod|END_ENTITY	bFGF induced the expression of the transcription factor ETS-1 in MSS31 cells .
23117547	0	b_carotene	117,127	PPAR_gamma	78,88	b carotene	PPAR gamma	null	19016(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|dep|effect	Ang_II induce kidney_damage by recruiting inflammatory cells and up regulates PPAR_gamma and Renin_1 gene : effect of b_carotene on chronic renal_damage .
21786025	0	b_carotene	18,28	apo_E	92,97	b carotene	apo E	null	11816(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of dietary b_carotene on cerebral_aneurysm and subarachnoid_haemorrhage in the brain apo_E - / - mice .
22506594	0	baccharin	82,91	AKR1C3	71,77	baccharin	AKR1C3	MESH:C012764	8644	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|appos|END_ENTITY	Selective inhibition of human type-5 17b-hydroxysteroid dehydrogenase -LRB- AKR1C3 -RRB- by baccharin , a component of Brazilian propolis .
2227108	0	bacitracin	10,20	insulin	60,67	bacitracin	insulin	MESH:D001414	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of bacitracin on retroendocytosis and degradation of insulin in cultured kidney epithelial cell line .
6756390	0	bacitracin	32,42	insulin	60,67	bacitracin	insulin	MESH:D001414	3630	Chemical	Gene	Evidence|nmod|START_ENTITY Evidence|nmod|degradation degradation|compound|END_ENTITY	Evidence for a direct effect of bacitracin on cell-mediated insulin degradation in isolated hepatocytes .
8309627	0	baclofen	79,87	Fos	20,23	baclofen	Fos	MESH:D001418	2353	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|induction induction|nmod|END_ENTITY	Photic induction of Fos in the hamster suprachiasmatic nucleus is inhibited by baclofen but not by diazepam or bicucullin .
2171571	0	baclofen	69,77	GH	54,56	baclofen	GH	MESH:D001418	2688	Chemical	Gene	response|acl|START_ENTITY response|compound|END_ENTITY	Chronic antidepressant drug treatment does not affect GH response to baclofen in depressed subjects .
9387146	0	baclofen	23,31	GnRH	48,52	baclofen	GnRH	MESH:D001418	25194(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Differential effect of baclofen on hypothalamic GnRH and pituitary LH_beta gene expression in steroid-treated rats .
10101723	0	baclofen	27,35	Growth_hormone	0,14	baclofen	Growth hormone	MESH:D001418	2688	Chemical	Gene	response|acl|START_ENTITY response|amod|END_ENTITY	Growth_hormone response to baclofen in patients with seasonal_affective_disorder : effects of light therapy .
10639686	0	baclofen	27,35	Growth_hormone	0,14	baclofen	Growth hormone	MESH:D001418	2688	Chemical	Gene	response|acl|START_ENTITY response|amod|END_ENTITY	Growth_hormone response to baclofen in patients with mania : a pilot study .
11549874	0	baclofen	31,39	Growth_hormone	0,14	baclofen	Growth hormone	MESH:D001418	2688	Chemical	Gene	administration|compound|START_ENTITY END_ENTITY|nmod|administration	Growth_hormone secretion after baclofen administration in different phases of the menstrual cycle in healthy women .
21181128	0	baclofen	58,66	Growth_hormone	0,14	baclofen	Growth hormone	MESH:D001418	2688	Chemical	Gene	challenge|nmod|START_ENTITY challenge|nsubj|responses responses|amod|END_ENTITY	Growth_hormone responses to GABAB receptor challenge with baclofen and impulsivity in healthy control and personality_disorder subjects .
8852867	0	baclofen	27,35	Growth_hormone	0,14	baclofen	Growth hormone	MESH:D001418	2688	Chemical	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Growth_hormone response to baclofen : a comparison of 10-mg and 20-mg doses in healthy men .
2547646	0	baclofen	43,51	gastrin	16,23	baclofen	gastrin	MESH:D001418	25320(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY release|acl|induced release|compound|END_ENTITY	GABA-A-mediated gastrin release induced by baclofen in the isolated vascularly perfused rat stomach .
1625515	0	baclofen	58,66	growth_hormone	81,95	baclofen	growth hormone	MESH:D001418	2688	Chemical	Gene	START_ENTITY|xcomp|stimulate stimulate|dobj|secretion secretion|amod|END_ENTITY	Failure of the gamma-aminobutyric_acid -LRB- GABA -RRB- derivative , baclofen , to stimulate growth_hormone secretion in heroin addicts .
1772578	0	baclofen	58,66	growth_hormone	81,95	baclofen	growth hormone	MESH:D001418	2688	Chemical	Gene	START_ENTITY|xcomp|stimulate stimulate|dobj|secretion secretion|amod|END_ENTITY	Failure of the gamma-aminobutyric_acid -LRB- GABA -RRB- derivative , baclofen , to stimulate growth_hormone secretion in Parkinson 's _ disease .
8159779	0	baclofen	31,39	growth_hormone	4,18	baclofen	growth hormone	MESH:D001418	2688	Chemical	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	The growth_hormone response to baclofen in obsessive_compulsive_disorder : does the GABA-B receptor mediate obsessive anxiety ?
8175969	0	baclofen	8,16	growth_hormone	46,60	baclofen	growth hormone	MESH:D001418	2688	Chemical	Gene	therapy|compound|START_ENTITY improves|nsubj|therapy improves|dobj|response response|compound|END_ENTITY	Chronic baclofen therapy improves the blunted growth_hormone response to intravenous arginine in subjects with spinal_cord_injury .
9536450	0	baclofen	56,64	growth_hormone	29,43	baclofen	growth hormone	MESH:D001418	2688	Chemical	Gene	response|acl|START_ENTITY response|amod|END_ENTITY	Divalproex_sodium attenuates growth_hormone response to baclofen in healthy human males .
16554457	0	baclofen	19,27	insulin-like_growth_factor-I	53,81	baclofen	insulin-like growth factor-I	MESH:D001418	3479	Chemical	Gene	administration|compound|START_ENTITY Effect|nmod|administration END_ENTITY|nsubj|Effect	Effect of low-dose baclofen administration on plasma insulin-like_growth_factor-I in persons with spinal_cord_injury .
23370589	0	baclofen	103,111	pantothenate_kinase-associated_neurodegeneration	21,69	baclofen	pantothenate kinase-associated neurodegeneration	MESH:D001418	80025	Chemical	Gene	Treatment|nmod|START_ENTITY Treatment|nmod|END_ENTITY	Treatment of classic pantothenate_kinase-associated_neurodegeneration with deferiprone and intrathecal baclofen .
9835578	0	bacteriocin	127,138	enterocin_I	45,56	bacteriocin	enterocin I	CHEBI:48081	6384023(Tax:1352)	Chemical	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Purification and genetic characterization of enterocin_I from Enterococcus_faecium 6T1a , a novel antilisterial plasmid-encoded bacteriocin which does not belong to the pediocin family of bacteriocins .
16716805	0	baicalein	35,44	C/EBPbeta	123,132	baicalein	C/EBPbeta	MESH:C006680	12608(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activity activity|compound|END_ENTITY	Differential inhibitory effects of baicalein and baicalin on LPS-induced cyclooxygenase-2 expression through inhibition of C/EBPbeta DNA-binding activity .
19827298	0	baicalein	11,20	P-glycoprotein	102,116	baicalein	P-glycoprotein	MESH:C006680	287115(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|dep|role role|nmod|inhibition inhibition|amod|END_ENTITY	Effects of baicalein , an antioxidant , on the bioavailability of doxorubicin in rats : possible role of P-glycoprotein inhibition by baicalein .
19827298	0	baicalein	131,140	P-glycoprotein	102,116	baicalein	P-glycoprotein	MESH:C006680	287115(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Effects of baicalein , an antioxidant , on the bioavailability of doxorubicin in rats : possible role of P-glycoprotein inhibition by baicalein .
22001996	0	baicalein	143,152	P-glycoprotein	103,117	baicalein	P-glycoprotein	MESH:C006680	5243	Chemical	Gene	inhibition|nmod|START_ENTITY role|acl|inhibition role|nmod|END_ENTITY	Effects of the antioxidant baicalein on the pharmacokinetics of nimodipine in rats : a possible role of P-glycoprotein and CYP3A4 inhibition by baicalein .
22001996	0	baicalein	27,36	P-glycoprotein	103,117	baicalein	P-glycoprotein	MESH:C006680	5243	Chemical	Gene	Effects|nmod|START_ENTITY Effects|dep|role role|nmod|END_ENTITY	Effects of the antioxidant baicalein on the pharmacokinetics of nimodipine in rats : a possible role of P-glycoprotein and CYP3A4 inhibition by baicalein .
22139696	0	baicalein	182,191	P-glycoprotein	153,167	baicalein	P-glycoprotein	MESH:C006680	287115(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Effects of baicalein on the pharmacokinetics of tamoxifen and its main metabolite , 4-hydroxytamoxifen , in rats : possible role of cytochrome P450 3A4 and P-glycoprotein inhibition by baicalein .
19853588	0	baicalein	29,38	PPAR_gamma	50,60	baicalein	PPAR gamma	MESH:C006680	25664(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	12/15-Lipoxygenase inhibitor baicalein suppresses PPAR_gamma expression and nuclear translocation induced by cerebral_ischemia / reperfusion .
26136875	0	baicalein	10,19	SATB1	41,46	baicalein	SATB1	MESH:C006680	6304	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	Effect of baicalein on the expression of SATB1 in human breast_cancer cells .
23771668	0	baicalein	10,19	VIP	41,44	baicalein	VIP	MESH:C006680	7432	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of baicalein on the expression of VIP in extravillous cytotrophoblasts infected with human_cytomegalovirus in vitro .
16716805	0	baicalein	35,44	cyclooxygenase-2	73,89	baicalein	cyclooxygenase-2	MESH:C006680	19225(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|amod|END_ENTITY	Differential inhibitory effects of baicalein and baicalin on LPS-induced cyclooxygenase-2 expression through inhibition of C/EBPbeta DNA-binding activity .
15104249	0	baicalein	60,69	inducible_nitric_oxide_synthase	14,45	baicalein	inducible nitric oxide synthase	MESH:C006680	4843	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|expression expression|amod|END_ENTITY	Inhibition of inducible_nitric_oxide_synthase expression by baicalein in endotoxin/cytokine-stimulated microglia .
12865970	0	baicalein	11,20	mucin	60,65	baicalein	mucin	MESH:C006680	100508689	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|release release|compound|END_ENTITY	Effects of baicalein , berberine , curcumin and hesperidin on mucin release from airway goblet cells .
20627088	0	baicalin	52,60	Beta-Catenin	0,12	baicalin	Beta-Catenin	MESH:C038044	12387(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY mediates|dobj|effect mediates|nsubj|END_ENTITY	Beta-Catenin mediates the anti-adipogenic effect of baicalin .
25386078	0	baicalin	11,19	CD29	29,33	baicalin	CD29	MESH:C038044	3688	Chemical	Gene	START_ENTITY|nmod|cell cell|compound|END_ENTITY	Effects of baicalin in CD4 + CD29 + T cell subsets of ulcerative_colitis patients .
25386078	0	baicalin	11,19	CD4	23,26	baicalin	CD4	MESH:C038044	920	Chemical	Gene	START_ENTITY|nmod|cell cell|compound|END_ENTITY	Effects of baicalin in CD4 + CD29 + T cell subsets of ulcerative_colitis patients .
20580705	0	baicalin	48,56	CYP3A4	13,19	baicalin	CYP3A4	MESH:C038044	1576	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|expression expression|compound|END_ENTITY	Induction of CYP3A4 and MDR1 gene expression by baicalin , baicalein , chlorogenic_acid , and ginsenoside_Rf through constitutive_androstane_receptor - and pregnane_X_receptor-mediated pathways .
23110126	0	baicalin	65,73	CaMKKb	0,6	baicalin	CaMKKb	MESH:C038044	10645	Chemical	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	CaMKKb is involved in AMP-activated_protein_kinase activation by baicalin in LKB1 deficient cell lines .
26865578	0	baicalin	33,41	NLRP3	65,70	baicalin	NLRP3	MESH:C038044	114548	Chemical	Gene	START_ENTITY|nmod|suppression suppression|nmod|END_ENTITY	The anti-inflammatory effects of baicalin through suppression of NLRP3 inflammasome pathway in LPS-challenged piglet mononuclear phagocytes .
20863826	0	baicalin	23,31	NOD2	48,52	baicalin	NOD2	MESH:C038044	291912(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Comprehensive study of baicalin down-regulating NOD2 receptor expression of neurons with oxygen-glucose_deprivation in vitro and cerebral_ischemia-reperfusion in vivo .
12709894	0	baicalin	11,19	SP-A	68,72	baicalin	SP-A	MESH:C038044	653509	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of baicalin on the gene expression of surfactant_protein_A -LRB- SP-A -RRB- in lung_adenocarcinoma cell line H441 .
20471972	0	baicalin	22,30	TIMP-1	58,64	baicalin	TIMP-1	MESH:C038044	7076	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|END_ENTITY	Inhibitory effects of baicalin on IL-1beta - induced MMP-1 / TIMP-1 and its stimulated effect on collagen-I production in human periodontal ligament cells .
23947144	0	baicalin	11,19	TLR4	37,41	baicalin	TLR4	MESH:C038044	21898(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of baicalin on expression of TLR4 in RAW264 .7 cells infected by ESBLs Escherichia_coli -RSB- .
19937174	0	baicalin	13,21	TNF-alpha	25,34	baicalin	TNF-alpha	MESH:C038044	24835(Tax:10116)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|expression expression|amod|END_ENTITY	Influence of baicalin on TNF-alpha mRNA , caspase-3 and P-selectin expression in pancreatic tissue of rats with severe_acute_pancreatitis .
16824337	0	baicalin	11,19	heme_oxygenase-1	37,53	baicalin	heme oxygenase-1	MESH:C038044	24451(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of baicalin on expression of heme_oxygenase-1 in lung_injury of rats associated with paraquat_poisoning -RSB- .
24312512	0	baicalin	21,29	iNOS	33,37	baicalin	iNOS	MESH:C038044	24599(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Inhibitory effect of baicalin on iNOS and NO expression in intestinal mucosa of rats with acute endotoxemia .
12873450	0	baicalin	11,19	interleukin-6	47,60	baicalin	interleukin-6	MESH:C038044	3569	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effects of baicalin , baicalein , and wogonin on interleukin-6 and interleukin-8 expression , and nuclear_factor-kappab binding activities induced by interleukin-1beta in human retinal pigment epithelial cell line .
21678122	0	baicalin	10,18	matrix_metalloproteinase-9	22,48	baicalin	matrix metalloproteinase-9	MESH:C038044	81687(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effect of baicalin on matrix_metalloproteinase-9 expression and blood-brain barrier permeability following focal cerebral_ischemia in rats .
21302496	0	baicalin	11,19	protease-activated_receptor-1	23,52	baicalin	protease-activated receptor-1	MESH:C038044	25439(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effect of baicalin on protease-activated_receptor-1 expression and cell apoptosis in brain of rat with intracerebral_hemorrhage -RSB- .
22784286	0	baicalin	12,20	protease-activated_receptor-1	24,53	baicalin	protease-activated receptor-1	MESH:C038044	25439(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	`` Effects of baicalin on protease-activated_receptor-1 expression and brain_injury in a rat model of intracerebral_hemorrhage '' .
12709894	0	baicalin	11,19	surfactant_protein_A	46,66	baicalin	surfactant protein A	MESH:C038044	653509	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effects of baicalin on the gene expression of surfactant_protein_A -LRB- SP-A -RRB- in lung_adenocarcinoma cell line H441 .
16099107	0	baicalin	72,80	terminal_deoxyribonucleotidyltransferase	24,64	baicalin	terminal deoxyribonucleotidyltransferase	MESH:C038044	1791	Chemical	Gene	inhibitors|dep|START_ENTITY inhibitors|nmod|END_ENTITY	Selective inhibitors of terminal_deoxyribonucleotidyltransferase -LRB- TdT -RRB- : baicalin and genistin .
25345139	0	bakuchiol	22,31	ESF-1	35,40	bakuchiol	ESF-1	MESH:C012765	51575	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	-LSB- Regulative effect of bakuchiol on ESF-1 cells anti-aging gene -RSB- .
20128603	0	balanol	92,99	G_protein-coupled_receptor_kinase_2	19,54	balanol	G protein-coupled receptor kinase 2	MESH:C015405	156	Chemical	Gene	Structure|nmod|START_ENTITY Structure|nmod|END_ENTITY	Structure of human G_protein-coupled_receptor_kinase_2 in complex with the kinase inhibitor balanol .
15449725	0	bambuterol	57,67	butyrylcholinesterase	21,42	bambuterol	butyrylcholinesterase	MESH:C047766	590	Chemical	Gene	variants|nmod|START_ENTITY variants|nsubj|Interaction Interaction|nmod|END_ENTITY	Interaction of human butyrylcholinesterase variants with bambuterol and terbutaline .
23557198	0	barasertib	19,29	Aurora_B	0,8	barasertib	Aurora B	MESH:C520647	9212	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Aurora_B inhibitor barasertib and cytarabine exert a greater-than-additive cytotoxicity in acute_myeloid_leukemia cells .
8854204	0	basal_acid	60,70	gastrin	49,56	basal acid	gastrin	null	25320(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY END_ENTITY|nmod|secretion	Comparative evaluation of the role of endogenous gastrin in basal_acid secretion in conscious rats provided with chronic fistula and pylorus ligation .
20302758	0	batimastat	36,46	MMP-9	20,25	batimastat	MMP-9	MESH:C080985	403885(Tax:9615)	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|inhibitor inhibitor|compound|END_ENTITY	-LSB- Protective role of MMP-9 inhibitor batimastat in acute_lung_injury after cardiopulmonary bypass -RSB- .
12014135	0	batroxobin	10,20	neural_cell_adhesion_molecule	38,67	batroxobin	neural cell adhesion molecule	MESH:D012103	24586(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of batroxobin on expression of neural_cell_adhesion_molecule in temporal infarction rats and spatial_learning_and_memory_disorder .
25825214	0	beclomethasone	73,87	CYP3A5	10,16	beclomethasone	CYP3A5	MESH:D001507	1577	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|Effect Effect|nmod|END_ENTITY	Effect of CYP3A5 * 3 on asthma control among children treated with inhaled beclomethasone .
10202343	0	beclomethasone_dipropionate	19,46	IgE	56,59	beclomethasone dipropionate	IgE	MESH:D001507	3497	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Effects of inhaled beclomethasone_dipropionate on serum IgE levels and clinical symptoms in atopic_asthma .
16400894	0	beclomethasone_dipropionate	10,37	basic_fibroblast_growth_factor	41,71	beclomethasone dipropionate	basic fibroblast growth factor	MESH:D001507	2247	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|compound|END_ENTITY	Effect of beclomethasone_dipropionate on basic_fibroblast_growth_factor levels in induced sputum samples from asthmatic patients .
16100184	0	beclomethasone_dipropionate	8,35	growth_hormone	70,84	beclomethasone dipropionate	growth hormone	MESH:D001507	2688	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|compound|END_ENTITY	Inhaled beclomethasone_dipropionate acutely stimulates dose-dependent growth_hormone secretion in healthy subjects .
8210614	0	beclomethasone_dipropionate	145,172	growth_hormone	16,30	beclomethasone dipropionate	growth hormone	MESH:D001507	2688	Chemical	Gene	treated|nmod|START_ENTITY asthma|acl|treated children|nmod|asthma excretion|nmod|children _|dep|excretion _|nmod:poss|urine urine|amod|END_ENTITY	Overnight urine growth_hormone , cortisol and adenosine_3 ' _ 5 ' _ cyclic_monophosphate excretion in children with chronic asthma treated with inhaled beclomethasone_dipropionate .
10333983	0	befloxatone	23,34	MAO-A	53,58	befloxatone	MAO-A	MESH:C090014	29253(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Preclinical profile of befloxatone , a new reversible MAO-A inhibitor .
7931248	0	befloxatone	28,39	MAO-A	76,81	befloxatone	MAO-A	MESH:C090014	29253(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Biochemical pharmacology of befloxatone -LRB- MD370503 -RRB- , a new potent reversible MAO-A inhibitor .
7931249	0	befloxatone	11,22	MAO-A	48,53	befloxatone	MAO-A	MESH:C090014	29253(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effects of befloxatone , a new potent reversible MAO-A inhibitor , on cortex and striatum monoamines in freely moving rats .
8904739	0	befloxatone	43,54	MAO-A	73,78	befloxatone	MAO-A	MESH:C090014	4128	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Pharmacoelectroencephalographic profile of befloxatone , a new reversible MAO-A inhibitor , in healthy subjects .
7665725	0	befloxatone	54,65	monoamine_oxidase-A	84,103	befloxatone	monoamine oxidase-A	MESH:C090014	4128	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Pressor effect of oral tyramine during treatment with befloxatone , a new reversible monoamine_oxidase-A inhibitor , in healthy subjects .
8930782	0	befloxatone	11,22	monoamine_oxidase-A	47,66	befloxatone	monoamine oxidase-A	MESH:C090014	4128	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Effects of befloxatone , a reversible selective monoamine_oxidase-A inhibitor , on psychomotor function and memory in healthy subjects .
9570466	0	befloxatone	55,66	monoamine_oxidase-A	25,44	befloxatone	monoamine oxidase-A	MESH:C090014	29253(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|inhibitor inhibitor|amod|END_ENTITY	Effect of the reversible monoamine_oxidase-A inhibitor befloxatone on the rat 5-hydroxytryptamine neurotransmission .
10482460	0	befloxatone	44,55	monoamine_oxidase_A	13,32	befloxatone	monoamine oxidase A	MESH:C090014	4128	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	A reversible monoamine_oxidase_A inhibitor , befloxatone : structural approach of its mechanism of action .
9728902	0	befloxatone	65,76	monoamine_oxidase_A	105,124	befloxatone	monoamine oxidase A	MESH:C090014	4128	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Cognitive performance in elderly subjects after a single dose of befloxatone , a new reversible selective monoamine_oxidase_A inhibitor .
26758422	0	belinostat	20,30	S0520	101,106	belinostat	S0520	MESH:C487081	1076954(Tax:198215)	Chemical	Gene	study|nmod|START_ENTITY study|dep|END_ENTITY	A phase II study of belinostat -LRB- PXD101 -RRB- in relapsed and refractory aggressive B-cell_lymphomas : SWOG S0520 .
11273348	0	benazepril	26,36	ACE	44,47	benazepril	ACE	MESH:C044946	1636	Chemical	Gene	trial|nmod|START_ENTITY trial|dep|inhibitor inhibitor|compound|END_ENTITY	An open clinical trial of benazepril -- a new ACE inhibitor in mild-moderate hypertension .
15788353	0	benazepril	242,252	ACE	133,136	benazepril	ACE	MESH:C044946	1636	Chemical	Gene	treated|nmod|START_ENTITY patients|acl|treated left_ventricular_hypertrophy|nmod|patients inhibitor|nmod|left_ventricular_hypertrophy inhibitor|compound|END_ENTITY	A study of the relationships between angiotensin - converting enzyme gene , chymase gene polymorphisms , pharmacological treatment with ACE inhibitor and regression of left_ventricular_hypertrophy in essential hypertension patients treated with benazepril .
1893642	0	benazepril	24,34	ACE	53,56	benazepril	ACE	MESH:C044946	1636	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY pharmacokinetics|advmod|relative relative|nmod|inhibitors inhibitors|compound|END_ENTITY	The pharmacokinetics of benazepril relative to other ACE inhibitors .
9273485	0	benazepril	17,27	ACE	43,46	benazepril	ACE	MESH:C044946	1636	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	-LSB- Experience with benazepril , a long-acting ACE inhibitor , in the management of diabetic_hypertension -RSB- .
9328608	0	benazepril	28,38	ACE	10,13	benazepril	ACE	MESH:C044946	1636	Chemical	Gene	inhibition|advcl|START_ENTITY inhibition|nsubj|Effect Effect|nmod|END_ENTITY	Effect of ACE inhibition by benazepril , enalapril and captopril on chronic and post exercise proteinuria .
9335410	0	benazepril	22,32	ACE	111,114	benazepril	ACE	MESH:C044946	1636	Chemical	Gene	therapy|nmod|START_ENTITY therapy|nmod|inhibitor inhibitor|compound|END_ENTITY	Combined therapy with benazepril and amlodipine in the treatment of hypertension inadequately controlled by an ACE inhibitor alone .
15934302	0	benazepril	25,35	P42/44MAPK	72,82	benazepril	P42/44MAPK	MESH:C044946	116590(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY mediated|nsubj|effect mediated|nmod|END_ENTITY	Renoprotective effect of benazepril on diabetic_nephropathy mediated by P42/44MAPK .
8596594	0	benazepril	54,64	angiotensin-converting-enzyme	14,43	benazepril	angiotensin-converting-enzyme	MESH:C044946	1636	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|inhibitor inhibitor|amod|END_ENTITY	Effect of the angiotensin-converting-enzyme inhibitor benazepril on the progression of chronic renal_insufficiency .
11090788	0	benazepril	107,117	angiotensin-converting_enzyme	66,95	benazepril	angiotensin-converting enzyme	MESH:C044946	1636	Chemical	Gene	inhibitor|dep|START_ENTITY inhibitor|amod|END_ENTITY	Comparison of efficacy and side effects of combination therapy of angiotensin-converting_enzyme inhibitor -LRB- benazepril -RRB- with calcium antagonist -LRB- either nifedipine or amlodipine -RRB- versus high-dose calcium antagonist monotherapy for systemic hypertension .
8599524	0	benazepril	45,55	angiotensin-converting_enzyme	96,125	benazepril	angiotensin-converting enzyme	MESH:C044946	610668(Tax:9615)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Pharmacokinetics of the active metabolite of benazepril , benazeprilat , and inhibition of plasma angiotensin-converting_enzyme activity after single and repeated administrations to dogs .
10217360	0	benazepril	67,77	angiotensin_converting_enzyme	26,55	benazepril	angiotensin converting enzyme	MESH:C044946	100009274(Tax:9986)	Chemical	Gene	inhibitor|dep|START_ENTITY inhibitor|amod|END_ENTITY	Antiatherogenic effect of angiotensin_converting_enzyme inhibitor -LRB- benazepril -RRB- and angiotensin II receptor antagonist -LRB- valsartan -RRB- in the cholesterol-fed rabbits .
10651464	0	benazepril	70,80	angiotensin_converting_enzyme	7,36	benazepril	angiotensin converting enzyme	MESH:C044946	101094061	Chemical	Gene	activity|nmod|START_ENTITY END_ENTITY|dobj|activity	Plasma angiotensin_converting_enzyme activity and pharmacokinetics of benazepril and benazeprilat in cats after single and repeated oral administration of benazepril.HCl .
12867730	0	benazepril	44,54	angiotensin_converting_enzyme	3,32	benazepril	angiotensin converting enzyme	MESH:C044946	610668(Tax:9615)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	An angiotensin_converting_enzyme inhibitor , benazepril can be transformed to an active metabolite , benazeprilat , by the liver of dogs with ascitic pulmonary heartworm_disease .
1888695	0	benazepril	56,66	angiotensin_converting_enzyme	15,44	benazepril	angiotensin converting enzyme	MESH:C044946	1636	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Effects of the angiotensin_converting_enzyme inhibitor , benazepril , on the sino-aortic baroreceptor heart rate reflex .
1963190	0	benazepril	77,87	angiotensin_converting_enzyme	36,65	benazepril	angiotensin converting enzyme	MESH:C044946	1636	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|END_ENTITY	Systemic and renal effects of a new angiotensin_converting_enzyme inhibitor , benazepril , in essential hypertension .
22027785	0	benazepril	12,22	erythropoietin	40,54	benazepril	erythropoietin	MESH:C044946	2056	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|compound|END_ENTITY	-LSB- Effects of benazepril and valsartan on erythropoietin levels in patients with essential hypertension -RSB- .
9725782	0	benazepril	11,21	insulin	25,32	benazepril	insulin	MESH:C044946	3630	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|resistance resistance|compound|END_ENTITY	Effects of benazepril on insulin resistance and glucose_tolerance in uremia .
2537699	0	benazepril_hydrochloride	50,74	angiotensin-converting_enzyme	90,119	benazepril hydrochloride	angiotensin-converting enzyme	MESH:C044946	1636	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	A multicenter study of the safety and efficacy of benazepril_hydrochloride , a long-acting angiotensin-converting_enzyme inhibitor , in patients with chronic congestive_heart_failure .
2853611	0	benazepril_hydrochloride	65,89	angiotensin-converting_enzyme	25,54	benazepril hydrochloride	angiotensin-converting enzyme	MESH:C044946	610668(Tax:9615)	Chemical	Gene	START_ENTITY|nsubj|actions actions|nmod|inhibitor inhibitor|amod|END_ENTITY	Renal actions of the new angiotensin-converting_enzyme inhibitor benazepril_hydrochloride .
2919553	0	benazepril_hydrochloride	67,91	angiotensin-converting_enzyme	26,55	benazepril hydrochloride	angiotensin-converting enzyme	MESH:C044946	1636	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Pharmacokinetics of a new angiotensin-converting_enzyme inhibitor , benazepril_hydrochloride , in special populations .
9293618	0	benazeprilat	104,116	angiotensin-converting-enzyme	24,53	benazeprilat	angiotensin-converting-enzyme	MESH:C052133	610668(Tax:9615)	Chemical	Gene	Pharmacokinetics|appos|START_ENTITY Pharmacokinetics|nmod|inhibitor inhibitor|amod|END_ENTITY	Pharmacokinetics of the angiotensin-converting-enzyme inhibitor , benazepril , and its active metabolite , benazeprilat , in dog .
11016804	0	benidipine	68,78	endothelin-1	24,36	benidipine	endothelin-1	MESH:C061004	24323(Tax:10116)	Chemical	Gene	involvement|nmod|START_ENTITY involvement|nmod|END_ENTITY	Possible involvement of endothelin-1 in cardioprotective effects of benidipine .
1867835	0	benserazide	18,29	COMT	36,40	benserazide	COMT	MESH:D001545	712548(Tax:9544)	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|amod|END_ENTITY	Central action of benserazide after COMT inhibition demonstrated in vivo by PET .
16636577	0	benserazide	41,52	L-dopa_decarboxylase	10,30	benserazide	L-dopa decarboxylase	MESH:D001545	24311(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|inhibitor inhibitor|amod|END_ENTITY	Effect of L-dopa_decarboxylase inhibitor benserazide on renal function in streptozotocin-diabetic rats .
985031	0	benserazide	87,98	growth_hormone	69,83	benserazide	growth hormone	MESH:D001545	2688	Chemical	Gene	-RSB-|compound|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- Attempt at potentiation of the action of L-dopa on the secretion of growth_hormone by benserazide , disulfiram and propranolol -RSB- .
19350613	0	benzamide	11,20	histone_deacetylase	38,57	benzamide	histone deacetylase	MESH:C037689	9734	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Studies of benzamide - and thiol-based histone_deacetylase inhibitors in models of oxidative-stress-induced neuronal_death : identification of some HDAC3-selective inhibitors .
12207145	0	benzamide	37,46	prolactin	97,106	benzamide	prolactin	MESH:C037689	5617	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Long-term effects of the substituted benzamide derivative amisulpride on baseline and stimulated prolactin levels .
6827920	0	benzamide	18,27	prolactin	54,63	benzamide	prolactin	MESH:C037689	24683(Tax:10116)	Chemical	Gene	YM-09151-2|amod|START_ENTITY Effect|amod|YM-09151-2 Effect|nmod|levels levels|compound|END_ENTITY	Effect of a novel benzamide , YM-09151-2 , on rat serum prolactin levels .
16724231	0	benzamide_M344	4,18	SMN2	83,87	benzamide M344	SMN2	null	6607	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|compound|END_ENTITY	The benzamide_M344 , a novel histone deacetylase inhibitor , significantly increases SMN2 RNA/protein levels in spinal_muscular_atrophy cells .
6685967	0	benzamidine	56,67	high_molecular_weight_kininogen	96,127	benzamidine	high molecular weight kininogen	MESH:C032157	3827	Chemical	Gene	START_ENTITY|nmod|function function|nmod|END_ENTITY	Activation of factor XII in human plasma : protection by benzamidine of the cofactor function of high_molecular_weight_kininogen .
3540163	0	benzamidine	74,85	renin	113,118	benzamidine	renin	MESH:C032157	5972	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Effectiveness of Sepharose-bound trypsin versus liquid-phase trypsin plus benzamidine for activation of inactive renin in human plasma .
10987422	0	benzamidine	63,74	thrombin	84,92	benzamidine	thrombin	MESH:C032157	2147	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	Quantitative structure-intestinal permeability relationship of benzamidine analogue thrombin inhibitor .
7044006	0	benzamidines	25,37	acrosin	14,21	benzamidines	acrosin	MESH:D001550	49	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of acrosin by benzamidines .
23396138	0	benzanthracene	100,114	AhR	0,3	benzanthracene	AhR	MESH:C030935	196	Chemical	Gene	induction|nmod|START_ENTITY END_ENTITY|dep|induction	AhR - and NF-kB-dependent induction of interleukin-6 by co-exposure to the environmental contaminant benzanthracene and the cytokine tumor_necrosis_factor-a in human mammary MCF-7 cells .
15689153	0	benzazepine	149,160	D1/D5	161,166	benzazepine	D1/D5	CHEBI:35676	25802;51366	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|compound|END_ENTITY	Dopamine D1/D5 receptor antagonists with improved pharmacokinetics : design , synthesis , and biological evaluation of phenol bioisosteric analogues of benzazepine D1/D5 antagonists .
20064718	0	benzazepine	73,84	dopamine_D1_receptor	85,105	benzazepine	dopamine D1 receptor	CHEBI:35676	1812	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|amod|END_ENTITY	Remote functionalization of SCH_39166 : discovery of potent and selective benzazepine dopamine_D1_receptor antagonists .
1531365	0	benzazepines	106,118	dopamine_D-1_receptor	144,165	benzazepines	dopamine D-1 receptor	MESH:D001552	1812	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	A study on the contribution of the 1-phenyl substituent to the molecular electrostatic potentials of some benzazepines in relation to selective dopamine_D-1_receptor activity .
19048458	0	benzbromarone	11,24	adiponectin	44,55	benzbromarone	adiponectin	MESH:D001553	9370	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of benzbromarone and allopurinol on adiponectin in vivo and in vitro .
1378186	0	benzene	68,75	CD-1	79,83	benzene	CD-1	MESH:D001554	111334(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|compound|END_ENTITY	The mutagenic effects of low level sub-acute inhalation exposure to benzene in CD-1 mice .
18455711	0	benzene	44,51	CD-1	72,76	benzene	CD-1	MESH:D001554	111334(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|compound|END_ENTITY	Genotoxicity of intermittent co-exposure to benzene and toluene in male CD-1 mice .
6715872	0	benzene	69,76	N-acetyl-beta-D-glucosaminidase	0,31	benzene	N-acetyl-beta-D-glucosaminidase	MESH:D001554	10724	Chemical	Gene	exposed|nmod|START_ENTITY exposed|nsubj|END_ENTITY	N-acetyl-beta-D-glucosaminidase in lymphocytes of workers exposed to benzene and its homologues .
17562280	0	benzene	14,21	adenosine_deaminase	41,60	benzene	adenosine deaminase	MESH:D001554	24165(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|nmod|END_ENTITY	The effect of benzene on the activity of adenosine_deaminase in tissues of rats .
7540334	0	benzene	14,21	interleukin-1	51,64	benzene	interleukin-1	MESH:D001554	3552	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|amod|END_ENTITY	Effect of the benzene metabolite , hydroquinone , on interleukin-1 secretion by human monocytes in vitro .
7717869	0	benzene	54,61	interleukin-1_alpha	154,173	benzene	interleukin-1 alpha	MESH:D001554	16175(Tax:10090)	Chemical	Gene	analysis|nmod|START_ENTITY analysis|nmod|END_ENTITY	A morphological analysis of the short-term effects of benzene on the development of the hematological cells in the bone marrow of mice and the effects of interleukin-1_alpha on the process .
9313868	0	benzene	15,22	leukotriene_B4_receptor	23,46	benzene	leukotriene B4 receptor	MESH:D001554	1241	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|amod|END_ENTITY	Trisubstituted benzene leukotriene_B4_receptor antagonists : synthesis and structure-activity relationships .
18784769	0	benzene	57,64	p16_Ink4a	125,134	benzene	p16 Ink4a	MESH:D001554	12578(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	NTP report on the toxicology and carcinogenesis study of benzene -LRB- CAS No. 71-43-2 -RRB- in genetically modified haploinsufficient p16_Ink4a / p19_Arf mice -LRB- gavage study -RRB- .
18784769	0	benzene	57,64	p19_Arf	135,142	benzene	p19 Arf	MESH:D001554	12578(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	NTP report on the toxicology and carcinogenesis study of benzene -LRB- CAS No. 71-43-2 -RRB- in genetically modified haploinsufficient p16_Ink4a / p19_Arf mice -LRB- gavage study -RRB- .
21361354	0	benzenesulfonamides	19,38	carbonic_anhydrase_IX	56,77	benzenesulfonamides	carbonic anhydrase IX	null	768	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|END_ENTITY	Ureido-substituted benzenesulfonamides potently inhibit carbonic_anhydrase_IX and show antimetastatic activity in a model of breast_cancer metastasis .
43117	0	benzhydryl_piperazines	101,123	ATPase	59,65	benzhydryl piperazines	ATPase	null	1769	Chemical	Gene	using|dobj|START_ENTITY END_ENTITY|acl|using	An investigation into the roles of synaptic vesicular Mg + + - ATPase in neurotransmitter release , using benzhydryl_piperazines .
22882897	0	benzimidamides	75,89	BACE1	103,108	benzimidamides	BACE1	null	23621	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Synthesis , in vitro biological evaluation and molecular docking studies of benzimidamides as potential BACE1 inhibitors .
16513356	0	benzimidazole	39,52	AMP-activated_protein_kinase	75,103	benzimidazole	AMP-activated protein kinase	MESH:C031000	5563	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Synthesis and biological evaluation of benzimidazole derivatives as potent AMP-activated_protein_kinase activators .
23440991	2	benzimidazole	249,262	BUB1	266,270	benzimidazole	BUB1	MESH:C031000	699	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	The budding uninhibited by benzimidazole 1 -LRB- BUB1 -RRB- gene is a highly conserved protein that plays a critical role at the spindle assembly checkpoint during cell division .
18522867	0	benzimidazole	6,19	CB2	45,48	benzimidazole	CB2	MESH:C031000	1269	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	Novel benzimidazole derivatives as selective CB2 agonists .
20207537	0	benzimidazole	20,33	CXCR4	34,39	benzimidazole	CXCR4	MESH:C031000	7852	Chemical	Gene	START_ENTITY|dobj|antagonists antagonists|nummod|END_ENTITY	Novel N-substituted benzimidazole CXCR4 antagonists as potential anti-HIV agents .
24238902	0	benzimidazole	30,43	CYP1A2	105,111	benzimidazole	CYP1A2	MESH:C031000	1544	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|compound|END_ENTITY	Design and synthesis of novel benzimidazole derivatives as phosphodiesterase_10A inhibitors with reduced CYP1A2 inhibition .
21724404	0	benzimidazole	13,26	EGFR	61,65	benzimidazole	EGFR	MESH:C031000	1956	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Discovery of benzimidazole derivatives as novel multi-target EGFR , VEGFR-2 and PDGFR kinase inhibitors .
17499505	0	benzimidazole	23,36	ITK	51,54	benzimidazole	ITK	MESH:C031000	3702	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Hit-to-lead studies on benzimidazole inhibitors of ITK : discovery of a novel class of kinase inhibitors .
22464457	0	benzimidazole	103,116	Raf	117,120	benzimidazole	Raf	MESH:C031000	22882	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	In silico binding free energy predictability with - interaction energy-augmented scoring function : benzimidazole Raf inhibitors as a case study .
26669310	0	benzimidazole	37,50	TRPM7	51,56	benzimidazole	TRPM7	MESH:C031000	54822	Chemical	Gene	agonists|amod|START_ENTITY agonists|compound|END_ENTITY	Mibefradil represents a new class of benzimidazole TRPM7 channel agonists .
9493321	0	benzimidazole	55,68	angiotensin_II_type_1_receptor	69,99	benzimidazole	angiotensin II type 1 receptor	MESH:C031000	403836(Tax:9615)	Chemical	Gene	antagonist|amod|START_ENTITY antagonist|amod|END_ENTITY	Pharmacokinetics , metabolism and pharmacodynamics of a benzimidazole angiotensin_II_type_1_receptor antagonist in the beagle_dog and cynomologus monkey .
18539028	0	benzimidazole	35,48	glucagon_receptor	49,66	benzimidazole	glucagon receptor	MESH:C031000	14527(Tax:10090)	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|compound|END_ENTITY	Discovery of potent , orally active benzimidazole glucagon_receptor antagonists .
24837154	0	benzimidazole	6,19	phosphodiesterase_10A	35,56	benzimidazole	phosphodiesterase 10A	MESH:C031000	10846	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	Novel benzimidazole derivatives as phosphodiesterase_10A -LRB- PDE10A -RRB- inhibitors with improved metabolic stability .
21585709	0	benzimidazole_carboxamide	30,55	PARP-1	71,77	benzimidazole carboxamide	PARP-1	null	142	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Molecular modeling studies on benzimidazole_carboxamide derivatives as PARP-1 inhibitors using 3D-QSAR and docking .
26901666	0	benzimidazoles	24,38	corticotropin-releasing_factor_1	48,80	benzimidazoles	corticotropin-releasing factor 1	MESH:D001562	1394	Chemical	Gene	Design|nmod|START_ENTITY Design|nmod|antagonists antagonists|amod|END_ENTITY	Design and synthesis of benzimidazoles as novel corticotropin-releasing_factor_1 receptor antagonists .
16690315	0	benzimidazoles	43,57	melanin-concentrating_hormone_receptor_1	61,101	benzimidazoles	melanin-concentrating hormone receptor 1	MESH:D001562	2847	Chemical	Gene	START_ENTITY|nmod|antagonists antagonists|amod|END_ENTITY	Design and synthesis of orally efficacious benzimidazoles as melanin-concentrating_hormone_receptor_1 antagonists .
20724156	0	benzimidazoles	37,51	melanin_concentrating_hormone_receptor_1	55,95	benzimidazoles	melanin concentrating hormone receptor 1	MESH:D001562	2847	Chemical	Gene	START_ENTITY|nmod|antagonists antagonists|amod|END_ENTITY	Discovery of novel , orally available benzimidazoles as melanin_concentrating_hormone_receptor_1 -LRB- MCHR1 -RRB- antagonists .
17574418	0	benzimidazoles	36,50	melanocortin-4_receptor	100,123	benzimidazoles	melanocortin-4 receptor	MESH:D001562	4160	Chemical	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of a novel series of benzimidazoles as potent and selective antagonists of the human melanocortin-4_receptor .
7739015	0	benzisothiazolone	56,73	human_leukocyte_elastase	88,112	benzisothiazolone	human leukocyte elastase	MESH:C015699	1991	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Phosphonates and phosphinates : novel leaving groups for benzisothiazolone inhibitors of human_leukocyte_elastase .
7877139	0	benzisothiazolone	20,37	leukocyte_elastase	58,76	benzisothiazolone	leukocyte elastase	MESH:C015699	1991	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Orally bioavailable benzisothiazolone inhibitors of human leukocyte_elastase .
21515063	0	benzisoxazole	31,44	PPAR	60,64	benzisoxazole	PPAR	CHEBI:51549	5465	Chemical	Gene	START_ENTITY|nmod|agonists agonists|amod|END_ENTITY	Biological evaluation of novel benzisoxazole derivatives as PPAR agonists .
24089054	0	benzoate	20,28	D-amino_acid_oxidase	104,124	benzoate	D-amino acid oxidase	MESH:D001565	1610	Chemical	Gene	treatment|nmod|START_ENTITY treatment|dep|trial trial|nmod|inhibitor inhibitor|amod|END_ENTITY	Add-on treatment of benzoate for schizophrenia : a randomized , double-blind , placebo-controlled trial of D-amino_acid_oxidase inhibitor .
2883334	0	benzodiazepine	48,62	CCK	28,31	benzodiazepine	CCK	MESH:D001569	12424(Tax:10090)	Chemical	Gene	receptor|nmod|START_ENTITY receptor|compound|END_ENTITY	Possible involvement of the CCK receptor in the benzodiazepine antagonism to CCK in the mouse brain .
2883334	0	benzodiazepine	48,62	CCK	77,80	benzodiazepine	CCK	MESH:D001569	12424(Tax:10090)	Chemical	Gene	receptor|nmod|START_ENTITY involvement|nmod|receptor antagonism|nsubj|involvement antagonism|xcomp|END_ENTITY	Possible involvement of the CCK receptor in the benzodiazepine antagonism to CCK in the mouse brain .
8845007	0	benzodiazepine	75,89	CCK	29,32	benzodiazepine	CCK	MESH:D001569	414884(Tax:9031)	Chemical	Gene	sites|amod|START_ENTITY affinity|nmod|sites have|dobj|affinity have|nsubj|L-364 L-364|appos|antagonists antagonists|compound|END_ENTITY	L-364 ,718 and L-365 ,260 , two CCK antagonists , have no affinity for central benzodiazepine binding sites in chickens .
14744947	0	benzodiazepine	97,111	CYP1A2	26,32	benzodiazepine	CYP1A2	MESH:D001569	494010(Tax:9615)	Chemical	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Polymorphic expression of CYP1A2 leading to interindividual variability in metabolism of a novel benzodiazepine receptor partial inverse agonist in dogs .
9413024	0	benzodiazepine	95,109	GnRH	56,60	benzodiazepine	GnRH	MESH:D001569	25194(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY expression|nmod|receptor expression|amod|END_ENTITY	Role of adrenal and gonadal steroids in the response of GnRH gene expression to the endogenous benzodiazepine receptor ligand octadecaneuropeptide in the male rat brain .
2893356	0	benzodiazepine	44,58	MIF-1	0,5	benzodiazepine	MIF-1	MESH:D001569	9709	Chemical	Gene	receptor|compound|START_ENTITY binding|nsubj|receptor augment|xcomp|binding END_ENTITY|dep|augment	MIF-1 and Tyr-MIF-1 augment GABA-stimulated benzodiazepine receptor binding .
2908009	0	benzodiazepine	76,90	MIF-1	26,31	benzodiazepine	MIF-1	MESH:D001569	237412(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	Structural specificity of MIF-1 and Tyr-MIF-1 in augmenting GABA-stimulated benzodiazepine receptor binding .
12482423	0	benzodiazepine	87,101	PBR	112,115	benzodiazepine	PBR	MESH:D001569	24230(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	-LSB- 18F -RSB- FMDAA1106 and -LSB- 18F -RSB- FEDAA1106 : two positron-emitter labeled ligands for peripheral benzodiazepine receptor -LRB- PBR -RRB- .
14626449	0	benzodiazepine	25,39	PBR	50,53	benzodiazepine	PBR	MESH:D001569	706	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Expression of peripheral benzodiazepine receptor -LRB- PBR -RRB- in human tumors : relationship to breast , _ colorectal , _ and_prostate_tumor progression .
15710359	0	benzodiazepine	11,25	PBR	36,39	benzodiazepine	PBR	MESH:D001569	706	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Peripheral benzodiazepine receptor -LRB- PBR -RRB- ligand cytotoxicity unrelated to PBR expression .
15710359	0	benzodiazepine	11,25	PBR	74,77	benzodiazepine	PBR	MESH:D001569	706	Chemical	Gene	receptor|compound|START_ENTITY ligand|nsubj|receptor ligand|nmod|expression expression|compound|END_ENTITY	Peripheral benzodiazepine receptor -LRB- PBR -RRB- ligand cytotoxicity unrelated to PBR expression .
16691503	0	benzodiazepine	35,49	PBR	60,63	benzodiazepine	PBR	MESH:D001569	24230(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Increased expression of peripheral benzodiazepine receptor -LRB- PBR -RRB- in dimethylbenz -LSB- a -RSB- anthracene-induced mammary_tumors in rats .
8709127	0	benzodiazepine	125,139	PBR	150,153	benzodiazepine	PBR	MESH:D001569	24230(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY binding|nmod|receptor derivatives|acl|binding derivatives|appos|END_ENTITY	Cardiovascular characterization of pyrrolo -LSB- 2,1-d -RSB- -LSB- 1,5 -RSB- benzothiazepine derivatives binding selectively to the peripheral-type benzodiazepine receptor -LRB- PBR -RRB- : from dual PBR affinity and calcium antagonist activity to novel and selective calcium entry blockers .
8709127	0	benzodiazepine	125,139	PBR	166,169	benzodiazepine	PBR	MESH:D001569	24230(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY binding|nmod|receptor derivatives|acl|binding -LSB-|dobj|derivatives -LSB-|nmod|affinity affinity|compound|END_ENTITY	Cardiovascular characterization of pyrrolo -LSB- 2,1-d -RSB- -LSB- 1,5 -RSB- benzothiazepine derivatives binding selectively to the peripheral-type benzodiazepine receptor -LRB- PBR -RRB- : from dual PBR affinity and calcium antagonist activity to novel and selective calcium entry blockers .
9888528	0	benzodiazepine	46,60	PBR	71,74	benzodiazepine	PBR	MESH:D001569	24230(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	In vivo studies on the role of the peripheral benzodiazepine receptor -LRB- PBR -RRB- in steroidogenesis .
2535706	0	benzodiazepine	57,71	Pyruvate_dehydrogenase	0,22	benzodiazepine	Pyruvate dehydrogenase	MESH:D001569	54704	Chemical	Gene	receptors|compound|START_ENTITY END_ENTITY|nmod|receptors	Pyruvate_dehydrogenase interactions with peripheral-type benzodiazepine receptors .
18212144	0	benzodiazepine	17,31	S100B	0,5	benzodiazepine	S100B	MESH:D001569	6285	Chemical	Gene	protein|nmod|START_ENTITY protein|nummod|END_ENTITY	S100B protein in benzodiazepine overdose .
24692541	0	benzodiazepine	115,129	TSPO	172,176	benzodiazepine	TSPO	MESH:D001569	12257(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Regulation of the mitochondrial permeability transition pore by the outer membrane does not involve the peripheral benzodiazepine receptor -LRB- Translocator_Protein_of_18_kDa -LRB- TSPO -RRB- -RRB- .
24692541	0	benzodiazepine	115,129	Translocator_Protein_of_18_kDa	140,170	benzodiazepine	Translocator Protein of 18 kDa	MESH:D001569	12257(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|dep|END_ENTITY	Regulation of the mitochondrial permeability transition pore by the outer membrane does not involve the peripheral benzodiazepine receptor -LRB- Translocator_Protein_of_18_kDa -LRB- TSPO -RRB- -RRB- .
17156911	0	benzodiazepine	15,29	Translocator_protein	40,60	benzodiazepine	Translocator protein	MESH:D001569	706	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|18kDa 18kDa|compound|END_ENTITY	The peripheral benzodiazepine receptor -LRB- Translocator_protein 18kDa -RRB- in microglia : from pathology to imaging .
24174323	0	benzodiazepine	32,46	Translocator_protein	0,20	benzodiazepine	Translocator protein	MESH:D001569	12257(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY required|nsubjpass|receptor END_ENTITY|parataxis|required	Translocator_protein / peripheral benzodiazepine receptor is not required for steroid hormone biosynthesis .
2437944	0	benzodiazepine	73,87	albumin	110,117	benzodiazepine	albumin	MESH:D001569	213	Chemical	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Age-dependence and free fatty_acid modulation of binding kinetics at the benzodiazepine binding site of serum albumin in neonates and adults determined using fast reaction methods .
9678260	0	benzodiazepine	25,39	aldose_reductase	71,87	benzodiazepine	aldose reductase	MESH:D001569	616199(Tax:9913)	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	The inhibitory effect of benzodiazepine derivatives on the bovine lens aldose_reductase enzyme .
2906441	0	benzodiazepine	67,81	gonadotropin-releasing_hormone	29,59	benzodiazepine	gonadotropin-releasing hormone	MESH:D001569	2796	Chemical	Gene	treatment|amod|START_ENTITY END_ENTITY|nmod|treatment	Plasma prolactin response to gonadotropin-releasing_hormone during benzodiazepine treatment .
1326109	0	benzodiazepine	39,53	growth_hormone	65,79	benzodiazepine	growth hormone	MESH:D001569	81668(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Effects of central and peripheral type benzodiazepine ligands on growth_hormone and gonadotropin secretion in male rats .
3081931	0	benzodiazepine	17,31	growth_hormone	50,64	benzodiazepine	growth hormone	MESH:D001569	2688	Chemical	Gene	administration|compound|START_ENTITY administration|nmod|END_ENTITY	Effects of acute benzodiazepine administration on growth_hormone , prolactin and cortisol release after moderate insulin-induced hypoglycemia in normal women .
6138010	0	benzodiazepine	10,24	growth_hormone	47,61	benzodiazepine	growth hormone	MESH:D001569	2688	Chemical	Gene	blunts|amod|START_ENTITY END_ENTITY|nsubj|blunts	Long-term benzodiazepine administration blunts growth_hormone response to diazepam .
7914003	0	benzodiazepine	11,25	growth_hormone	50,64	benzodiazepine	growth hormone	MESH:D001569	81668(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|nmod|proliferation proliferation|amod|END_ENTITY	Peripheral benzodiazepine stimulates secretion of growth_hormone and mitochondrial proliferation in pituitary_tumour GH3 cells .
8082875	3	benzodiazepine	476,490	man	536,539	benzodiazepine	CRH	MESH:D001569	1392	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	A comparison of the effects of a benzodiazepine on the stress - and CRH-induced activation in man has not been undertaken so far .
9004910	0	benzodiazepine	76,90	omega_3	102,109	benzodiazepine	omega 3	MESH:D001569	706	Chemical	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Synthesis and evaluation of -LSB- 123I -RSB- - iodo-PK11195 for mapping peripheral-type benzodiazepine receptors -LRB- omega_3 -RRB- in heart .
11168905	0	benzodiazepine	125,139	prolactin	25,34	benzodiazepine	prolactin	MESH:D001569	5617	Chemical	Gene	consumption|amod|START_ENTITY sleep|dobj|consumption improve|ccomp|sleep doses|acl:relcl|improve Lack|nmod|doses Lack|nmod|END_ENTITY	Lack of changes in serum prolactin , FSH , TSH , and estradiol after melatonin treatment in doses that improve sleep and reduce benzodiazepine consumption in sleep-disturbed , middle-aged , and elderly patients .
2906441	0	benzodiazepine	67,81	prolactin	7,16	benzodiazepine	prolactin	MESH:D001569	5617	Chemical	Gene	treatment|amod|START_ENTITY gonadotropin-releasing_hormone|nmod|treatment END_ENTITY|advcl|gonadotropin-releasing_hormone	Plasma prolactin response to gonadotropin-releasing_hormone during benzodiazepine treatment .
6320963	0	benzodiazepine	4,18	prolactin	79,88	benzodiazepine	prolactin	MESH:D001569	24683(Tax:10116)	Chemical	Gene	diazepam|amod|START_ENTITY inhibits|nsubj|diazepam inhibits|dobj|release release|compound|END_ENTITY	The benzodiazepine agonist diazepam inhibits basal and secretagogue-stimulated prolactin release in vitro .
9576607	0	benzodiazepine	93,107	prolactin	49,58	benzodiazepine	prolactin	MESH:D001569	24683(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Influence of adrenal glands on the modulation of prolactin gene expression by the endogenous benzodiazepine ligand octadecaneuropeptide in the male rat pituitary gland .
21889488	0	benzodiazepine	37,51	translocator_protein	4,24	benzodiazepine	translocator protein	MESH:D001569	24230(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY END_ENTITY|appos|receptor	The translocator_protein -LRB- peripheral benzodiazepine receptor -RRB- mediates rat-selective activation of the mitochondrial permeability transition by norbormide .
22295097	0	benzodiazepine	44,58	translocator_protein	11,31	benzodiazepine	translocator protein	MESH:D001569	12257(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY expression|appos|receptor expression|amod|END_ENTITY	The 18 kDa translocator_protein -LRB- peripheral benzodiazepine receptor -RRB- expression in the bone of normal , osteoprotegerin or low calcium diet treated mice .
24040265	0	benzodiazepine	60,74	translocator_protein	28,48	benzodiazepine	translocator protein	MESH:D001569	12257(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY expression|dep|receptor expression|nmod|END_ENTITY	Developmental expression of translocator_protein / peripheral benzodiazepine receptor in reproductive tissues .
19005028	0	benzodiazepines	24,39	CYP3A4	43,49	benzodiazepines	CYP3A4	MESH:D001569	1576	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Metabolic activation of benzodiazepines by CYP3A4 .
2859216	0	benzodiazepines	30,45	Cholecystokinin	0,15	benzodiazepines	Cholecystokinin	MESH:D001569	100735029	Chemical	Gene	antagonism|nmod|START_ENTITY antagonism|nsubj|END_ENTITY	Cholecystokinin antagonism by benzodiazepines in the contractile response of the isolated guinea-pig gallbladder .
2869533	0	benzodiazepines	30,45	Cholecystokinin	0,15	benzodiazepines	Cholecystokinin	MESH:D001569	12424(Tax:10090)	Chemical	Gene	antagonism|nmod|START_ENTITY antagonism|nsubj|END_ENTITY	Cholecystokinin antagonism by benzodiazepines in the food intake in mice .
2873044	0	benzodiazepines	11,26	cholecystokinin	105,120	benzodiazepines	cholecystokinin	MESH:D001569	25298(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of benzodiazepines on responses of guinea-pig ileum and gall-bladder and rat pancreatic acini to cholecystokinin .
6979001	0	benzodiazepines	38,53	prolactin	15,24	benzodiazepines	prolactin	MESH:D001569	24683(Tax:10116)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Suppression Suppression|nmod|END_ENTITY	Suppression of prolactin secretion by benzodiazepines in vivo .
2538195	0	benzodiazepines	19,34	thyrotropin-releasing_hormone	40,69	benzodiazepines	thyrotropin-releasing hormone	MESH:D001569	25569(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|receptors receptors|amod|END_ENTITY	The interaction of benzodiazepines with thyrotropin-releasing_hormone receptors on clonal pituitary cells .
18673142	0	benzodipyrazoles	34,50	cyclin_dependent_kinase_2	54,79	benzodipyrazoles	cyclin dependent kinase 2	null	1017	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	3D-QSAR CoMFA and CoMSIA study on benzodipyrazoles as cyclin_dependent_kinase_2 inhibitors .
23902929	1	benzofuran	95,105	CYP2A6	169,175	benzofuran	CYP2A6	MESH:C105430	1548	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	benzofuran and coumarin derivatives as potent and selective inhibitors of CYP2A6 .
21676612	0	benzofuran	41,51	EP1	52,55	benzofuran	EP1	MESH:C105430	5731	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|compound|END_ENTITY	Discovery of a novel series of nonacidic benzofuran EP1 receptor antagonists .
26619301	0	benzofuran	8,18	H1_receptor	100,111	benzofuran	H1 receptor	MESH:C105430	24448(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	A novel benzofuran , 4-methoxybenzofuran-5-carboxamide , from Tephrosia purpurea suppressed histamine H1_receptor gene expression through a protein kinase C - - dependent signaling pathway .
16698271	0	benzofuran	6,16	mitogen-activated_protein_kinase_phosphatase-1	37,83	benzofuran	mitogen-activated protein kinase phosphatase-1	MESH:C105430	1843	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|nmod|END_ENTITY	Novel benzofuran inhibitors of human mitogen-activated_protein_kinase_phosphatase-1 .
23220646	0	benzoheterocyclic	30,47	acrosin	69,76	benzoheterocyclic	acrosin	null	49	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Design and synthesis of novel benzoheterocyclic derivatives as human acrosin inhibitors by scaffold hopping .
19230393	0	benzoic_acid	13,25	Alba	52,56	benzoic acid	Alba	MESH:D019817	173	Chemical	Gene	content|amod|START_ENTITY content|nmod|END_ENTITY	-LSB- Analysis of benzoic_acid content in Radix Paeoniae Alba treated by different process -RSB- .
7589179	0	benzoic_acid	11,23	insulin	45,52	benzoic acid	insulin	MESH:D019817	105613195	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of benzoic_acid and its analogues on insulin and glucagon secretion in sheep .
24400806	0	benzoic_acid_ester	15,33	PDE4	56,60	benzoic acid ester	PDE4	null	5141	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	Novel class of benzoic_acid_ester derivatives as potent PDE4 inhibitors for inhaled administration in the treatment of respiratory_diseases .
24632143	0	benzoic_acid_hydrazide	120,142	myeloperoxidase	101,116	benzoic acid hydrazide	myeloperoxidase	MESH:C006712	4353	Chemical	Gene	analogs|amod|START_ENTITY leading|nmod|analogs leading|nmod|inactivation inactivation|nmod|END_ENTITY	Ordered cleavage of myeloperoxidase ester bonds releases active site heme leading to inactivation of myeloperoxidase by benzoic_acid_hydrazide analogs .
24632143	0	benzoic_acid_hydrazide	120,142	myeloperoxidase	20,35	benzoic acid hydrazide	myeloperoxidase	MESH:C006712	4353	Chemical	Gene	analogs|amod|START_ENTITY leading|nmod|analogs heme|acl|leading releases|dobj|heme releases|nsubj|cleavage cleavage|nmod|bonds bonds|amod|END_ENTITY	Ordered cleavage of myeloperoxidase ester bonds releases active site heme leading to inactivation of myeloperoxidase by benzoic_acid_hydrazide analogs .
25688920	0	benzoic_acid_hydrazide	35,57	myeloperoxidase	16,31	benzoic acid hydrazide	myeloperoxidase	MESH:C006712	4353	Chemical	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of myeloperoxidase by benzoic_acid_hydrazide .
7772042	0	benzoic_acid_hydrazides	33,56	myeloperoxidase	14,29	benzoic acid hydrazides	myeloperoxidase	null	4353	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of myeloperoxidase by benzoic_acid_hydrazides .
3670280	0	benzomorphan_opiate	17,36	acetylcholinesterase	42,62	benzomorphan opiate	acetylcholinesterase	null	43	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of a benzomorphan_opiate with acetylcholinesterase and the nicotinic acetylcholine receptor .
21621413	0	benzonaphthyridinone	51,71	mTOR	98,102	benzonaphthyridinone	mTOR	null	21977(Tax:10090)	Chemical	Gene	analogs|compound|START_ENTITY analogs|nmod|END_ENTITY	Discovery and optimization of potent and selective benzonaphthyridinone analogs as small molecule mTOR inhibitors with improved mouse microsome stability .
16997798	0	benzophenone-2	20,34	interferon-gamma	83,99	benzophenone-2	interferon-gamma	MESH:C035476	15978(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	In vitro effects of benzophenone-2 and octyl-methoxycinnamate on the production of interferon-gamma and interleukin-10 by murine splenocytes .
22190402	0	benzophenones	19,32	TNF-a	71,76	benzophenones	TNF-a	MESH:D001577	7124	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|expression expression|amod|END_ENTITY	Arylalkyl_ketones , benzophenones , desoxybenzoins and chalcones inhibit TNF-a induced expression of ICAM-1 : structure-activity analysis .
21215625	0	benzopyran	88,98	COX-2	99,104	benzopyran	COX-2	CHEBI:22727	4513	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Structure-based parallel medicinal chemistry approach to improve metabolic stability of benzopyran COX-2 inhibitors .
1422579	0	benzopyran	71,81	endothelin-1	24,36	benzopyran	endothelin-1	CHEBI:22727	24323(Tax:10116)	Chemical	Gene	openers|compound|START_ENTITY effects|nmod|openers effects|nmod|properties properties|amod|END_ENTITY	Differential effects of endothelin-1 on the vasorelaxant properties of benzopyran and non-benzopyran potassium channel openers .
24471437	0	benzopyran	82,92	insulin-regulated_aminopeptidase	107,139	benzopyran	insulin-regulated aminopeptidase	CHEBI:22727	171105(Tax:10116)	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|nmod|END_ENTITY	Synthesis , structure-activity relationships and brain uptake of a novel series of benzopyran inhibitors of insulin-regulated_aminopeptidase .
21707078	0	benzopyrimido-pyrrolo-oxazine-dione	29,64	CFTR	71,75	benzopyrimido-pyrrolo-oxazine-dione	CFTR	null	1080	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Potent , metabolically stable benzopyrimido-pyrrolo-oxazine-dione -LRB- BPO -RRB- CFTR inhibitors for polycystic_kidney_disease .
7493000	0	benzoquinones	95,108	phospholipase_A2	129,145	benzoquinones	phospholipase A2	MESH:D016227	151056	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effects of 6 - -LRB- 10-hydroxydecyl -RRB- -2,3 - dimethoxy-5-methyl-1 ,4 - benzoquinone -LRB- idebenone -RRB- and related benzoquinones on porcine pancreas phospholipase_A2 activity .
23099099	0	benzothiazepinones	36,54	glycogen_synthase_kinase-3b	78,105	benzothiazepinones	glycogen synthase kinase-3b	null	2932	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Identification of novel scaffold of benzothiazepinones as non-ATP competitive glycogen_synthase_kinase-3b inhibitors through virtual screening .
19181526	0	benzothiazole	13,26	MTP	78,81	benzothiazole	MTP	MESH:C005465	17775(Tax:10090)	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Discovery of benzothiazole derivatives as efficacious and enterocyte-specific MTP inhibitors .
22295239	0	benzothiazoles	140,154	aryl_hydrocarbon_receptor	12,37	benzothiazoles	aryl hydrocarbon receptor	MESH:D052160	196	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	The role of aryl_hydrocarbon_receptor and crosstalk with estrogen receptor in response of breast_cancer cells to the novel antitumor agents benzothiazoles and aminoflavone .
20237073	0	benzothiophene	2,16	mitogen-activated_protein_kinase-activated_protein_kinase_2	30,89	benzothiophene	mitogen-activated protein kinase-activated protein kinase 2	MESH:C088015	9261	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|nmod|END_ENTITY	A benzothiophene inhibitor of mitogen-activated_protein_kinase-activated_protein_kinase_2 inhibits tumor_necrosis_factor_alpha production and has oral anti-inflammatory efficacy in acute and chronic models of inflammation .
26755394	0	benzothiophene_amides	18,39	nicotinamide_phosphoribosyltransferase	70,108	benzothiophene amides	nicotinamide phosphoribosyltransferase	null	10135	Chemical	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of benzothiophene_amides as potent inhibitors of human nicotinamide_phosphoribosyltransferase .
2153828	0	benzothiophenes	66,81	5-lipoxygenase	99,113	benzothiophenes	5-lipoxygenase	CHEBI:38767	240	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	1,4-Dihydronaphthoquinones , hydroindoloquinones , benzofurans , and benzothiophenes as inhibitors of 5-lipoxygenase .
16184436	0	benzoxazine	74,85	oxytocin_receptor	52,69	benzoxazine	oxytocin receptor	CHEBI:46969	5021	Chemical	Gene	antagonists|amod|START_ENTITY END_ENTITY|nmod|antagonists	The 3D structure of the binding pocket of the human oxytocin_receptor for benzoxazine antagonists , determined by molecular docking , scoring functions and 3D-QSAR methods .
20570511	0	benzoxazole	45,56	c-Met	74,79	benzoxazole	c-Met	CHEBI:46700	24553(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Discovery of aminopyridines substituted with benzoxazole as orally active c-Met kinase inhibitors .
23266122	0	benzoxazole	6,17	mPGES-1	32,39	benzoxazole	mPGES-1	CHEBI:46700	64292(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|inhibitors inhibitors|nmod|END_ENTITY	Novel benzoxazole inhibitors of mPGES-1 .
22579487	0	benzoxazoles	81,93	c-Met	97,102	benzoxazoles	c-Met	MESH:D001583	4233	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Synthesis and structure-activity relationship of aminopyridines with substituted benzoxazoles as c-Met kinase inhibitors .
23298810	0	benzoxazoles	51,63	mPGES-1	81,88	benzoxazoles	mPGES-1	MESH:D001583	64292(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Synthesis and biological evaluation of substituted benzoxazoles as inhibitors of mPGES-1 : use of a conformation-based hypothesis to facilitate compound design .
22884355	0	benzoxazolone	64,77	translocator_protein	100,120	benzoxazolone	translocator protein	MESH:C017057	24230(Tax:10116)	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	Design , synthesis and structure-activity relationships of novel benzoxazolone derivatives as 18 kDa translocator_protein -LRB- TSPO -RRB- ligands .
17020160	0	benzoyl_urea	4,16	NR2B	38,42	benzoyl urea	NR2B	CHEBI:39416	14812(Tax:10090)	Chemical	Gene	derivatives|compound|START_ENTITY END_ENTITY|nsubj|derivatives	New benzoyl_urea derivatives as novel NR2B selective NMDA receptor antagonists .
6527272	0	benztropine_mesylate	11,31	prolactin	55,64	benztropine mesylate	prolactin	MESH:D001590	24683(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of benztropine_mesylate on haloperidol-induced prolactin secretion and serum haloperidol levels in rats .
20816875	0	benztropines	22,34	dopamine_transporter	55,75	benztropines	dopamine transporter	null	6531	Chemical	Gene	sites|nmod|START_ENTITY sites|nmod|END_ENTITY	The binding sites for benztropines and dopamine in the dopamine_transporter overlap .
22504721	0	benzyl-N-acetyl-a-galactosaminide	10,43	KL-6	47,51	benzyl-N-acetyl-a-galactosaminide	KL-6	null	4582	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of benzyl-N-acetyl-a-galactosaminide on KL-6 mucin expression and invasive properties of a human pancreatic_carcinoma cell line .
2981480	0	benzyl_alcohol	11,25	PTH	29,32	benzyl alcohol	PTH	MESH:D019905	5741	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|system system|compound|END_ENTITY	Effects of benzyl_alcohol on PTH receptor-adenylate cyclase system of canine kidney .
9210188	0	benzyl_alcohol	14,28	interferon-gamma	50,66	benzyl alcohol	interferon-gamma	MESH:D019905	3458	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of benzyl_alcohol on recombinant human interferon-gamma .
18929648	0	benzyl_alcohol	8,22	lysozyme	103,111	benzyl alcohol	lysozyme	MESH:D019905	4069	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of benzyl_alcohol in the prevention of heat-induced aggregation and inactivation of hen egg white lysozyme .
20980153	0	benzyl_ester_meperidine	44,67	serotonin_transporter	111,132	benzyl ester meperidine	serotonin transporter	null	6532	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Synthesis and structure-activity studies of benzyl_ester_meperidine and normeperidine derivatives as selective serotonin_transporter ligands .
24909680	0	benzyl_ether	29,41	S1P	78,81	benzyl ether	S1P	CHEBI:59859	89842(Tax:10116)	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	Synthesis and SAR studies of benzyl_ether derivatives as potent orally active S1P agonists .
10850952	0	benzyl_ethers	70,83	monoamine_oxidase_B	24,43	benzyl ethers	monoamine oxidase B	CHEBI:59859	4129	Chemical	Gene	START_ENTITY|nsubj|inhibition inhibition|nmod|END_ENTITY	Selective inhibition of monoamine_oxidase_B by aminoethyl substituted benzyl_ethers .
22476855	0	benzyl_isothiocyanate	21,42	Notch2	0,6	benzyl isothiocyanate	Notch2	MESH:C031403	4853	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Notch2 activation by benzyl_isothiocyanate impedes its inhibitory effect on breast_cancer cell migration .
19176463	0	benzyl_isothiocyanate	79,100	STAT-3	12,18	benzyl isothiocyanate	STAT-3	MESH:C031403	6774	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of STAT-3 in the induction of apoptosis in pancreatic_cancer cells by benzyl_isothiocyanate .
10409397	0	benzyl_isothiocyanate	39,60	cytochrome_P450_2E1	16,35	benzyl isothiocyanate	cytochrome P450 2E1	MESH:C031403	1571	Chemical	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of cytochrome_P450_2E1 by benzyl_isothiocyanate .
10667562	0	benzyl_isothiocyanate	59,80	glutathione_S-transferase	20,45	benzyl isothiocyanate	glutathione S-transferase	MESH:C031403	58962(Tax:10116)	Chemical	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Redox regulation of glutathione_S-transferase induction by benzyl_isothiocyanate : correlation of enzyme induction with the formation of reactive oxygen intermediates .
20667729	0	benzyl_tetrazoles	25,42	histamine_H3_receptor	46,67	benzyl tetrazoles	histamine H3 receptor	null	11255	Chemical	Gene	START_ENTITY|nmod|antagonists antagonists|amod|END_ENTITY	Discovery of substituted benzyl_tetrazoles as histamine_H3_receptor antagonists .
14609277	0	benzylamides	13,25	plasmin	67,74	benzylamides	plasmin	null	5340	Chemical	Gene	Synthesis|nmod|START_ENTITY Synthesis|nmod|END_ENTITY	Synthesis of benzylamides of dipeptides as potential inhibitors of plasmin .
13129579	0	benzylamines	76,88	monoamine_oxidase_B	30,49	benzylamines	monoamine oxidase B	MESH:D001596	4129	Chemical	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of mitochondrial monoamine_oxidase_B by methylthio-substituted benzylamines .
1244108	0	benzylhydrazine	38,53	tryptophan_pyrrolase	14,34	benzylhydrazine	tryptophan pyrrolase	MESH:C006730	64206(Tax:10116)	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of tryptophan_pyrrolase by benzylhydrazine .
8093737	0	benzylic	71,79	neuropeptide_Y	96,110	benzylic	neuropeptide Y	null	24604(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Benextramine-neuropeptide_Y receptor interactions : contribution of the benzylic moieties to -LSB- 3H -RSB- neuropeptide_Y displacement activity .
21949209	0	benzylisoquinoline_alkaloid	41,68	Tyrosine_aminotransferase	0,25	benzylisoquinoline alkaloid	Tyrosine aminotransferase	CHEBI:22750	6898	Chemical	Gene	contributes|xcomp|START_ENTITY contributes|nsubj|END_ENTITY	Tyrosine_aminotransferase contributes to benzylisoquinoline_alkaloid biosynthesis in opium poppy .
15550722	0	benzyloxy-substituted_lactone	9,38	cyclooxygenase-2	39,55	benzyloxy-substituted lactone	cyclooxygenase-2	null	29527(Tax:10116)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Use of a benzyloxy-substituted_lactone cyclooxygenase-2 inhibitor as a selective fluorescent probe for CYP3A activity in primary cultured rat and human hepatocytes .
7957664	0	benzyloxycarbonyl-Leu-Leu-Tyr_diazomethyl_ketone	89,137	TE2	30,33	benzyloxycarbonyl-Leu-Leu-Tyr diazomethyl ketone	TE2	null	8260	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of growth of human TE2 and C-33A cells by the cell-permeant calpain inhibitor benzyloxycarbonyl-Leu-Leu-Tyr_diazomethyl_ketone .
19193009	0	benzyloxyphenyl_piperidine-4-carboxamides	12,53	factor_Xa	107,116	benzyloxyphenyl piperidine-4-carboxamides	factor Xa	null	2159	Chemical	Gene	START_ENTITY|dep|inhibitors inhibitors|nmod|END_ENTITY	Fluorinated benzyloxyphenyl_piperidine-4-carboxamides with dual function against thrombosis : inhibitors of factor_Xa and platelet_aggregation .
16455807	0	bepotastine_besilate	94,114	P-glycoprotein	10,24	bepotastine besilate	P-glycoprotein	MESH:C511534	67078(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of P-glycoprotein on intestinal absorption and brain penetration of antiallergic agent bepotastine_besilate .
20625312	0	bepridil	21,29	SCN5A	124,129	bepridil	SCN5A	MESH:D015764	6331	Chemical	Gene	START_ENTITY|nmod|mutation mutation|compound|END_ENTITY	Efficacy of low-dose bepridil for prevention of ventricular_fibrillation in patients with Brugada_syndrome with and without SCN5A mutation .
3487326	0	bepridil	53,61	calmodulin	18,28	bepridil	calmodulin	MESH:D015764	24242(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|amod|END_ENTITY	Investigations on calmodulin antagonistic effects of bepridil in intact and skinned fibres of smooth muscle .
2351672	0	bepridil	33,41	cardiac_troponin_C	46,64	bepridil	cardiac troponin C	MESH:D015764	7134	Chemical	Gene	Binding|amod|START_ENTITY Binding|nmod|END_ENTITY	Binding of a calcium sensitizer , bepridil , to cardiac_troponin_C .
12601631	0	beraprost_sodium	42,58	vascular_cell_adhesion_molecule-1	63,96	beraprost sodium	vascular cell adhesion molecule-1	MESH:C048081	7412	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effects of the prostaglandin_I2 analogue , beraprost_sodium , on vascular_cell_adhesion_molecule-1 expression in human vascular endothelial cells and circulating vascular_cell_adhesion_molecule-1 level in patients with type_2_diabetes_mellitus .
17064567	0	berbamine	106,115	p210	83,87	berbamine	p210	MESH:C027870	2125	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- The mechanism of apoptosis of chronic_myeloid_leukemia cells induced by the novel p210 bcr/abl inhibitor berbamine -RSB- .
18928093	0	berberin_hydrochloride	11,33	cyclosporine_A	60,74	berberin hydrochloride	cyclosporine A	null	1161	Chemical	Gene	START_ENTITY|nmod|concentration concentration|nmod|END_ENTITY	-LSB- Effect of berberin_hydrochloride on blood concentration of cyclosporine_A in cardiac transplanted recipients -RSB- .
11243211	0	berberine	11,20	CA2	43,46	berberine	CA2	MESH:D001599	760	Chemical	Gene	START_ENTITY|nmod|concentration concentration|compound|END_ENTITY	-LSB- Effect of berberine on intracellular free CA2 + concentration in cultured brain cells -RSB- .
20658575	0	berberine	18,27	GPR40	70,75	berberine	GPR40	MESH:D001599	2864	Chemical	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of berberine as a novel agonist of fatty_acid receptor GPR40 .
23672049	0	berberine	11,20	HERG	49,53	berberine	HERG	MESH:D001599	3757	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Effect of berberine , liensinine and neferine on HERG channel expression -RSB- .
21061468	0	berberine	11,20	LOX-1	38,43	berberine	LOX-1	MESH:D001599	4973	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of berberine on expression of LOX-1 and SR-BI in human macrophage-derived foam cells induced by ox-LDL .
20935220	0	berberine	47,56	MDM2	15,19	berberine	MDM2	MESH:D001599	4193	Chemical	Gene	interaction|nmod|START_ENTITY END_ENTITY|nmod|interaction	Degradation of MDM2 by the interaction between berberine and DAXX leads to potent apoptosis in MDM2-overexpressing cancer cells .
15638014	0	berberine	11,20	PDE5	73,77	berberine	PDE5	MESH:D001599	171115(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	-LSB- Effect of berberine on the mRNA expression of phosphodiesterase_type_5 -LRB- PDE5 -RRB- in rat corpus cavernosum -RSB- .
23944062	0	berberine	24,33	TNF-alpha	52,61	berberine	TNF-alpha	MESH:D001599	7124	Chemical	Gene	START_ENTITY|nmod|expressions expressions|nmod|END_ENTITY	-LSB- Intervention effect of berberine on expressions of TNF-alpha and receptor type I in Abeta25-35-induced inflammatory reaction in SH-SY5Y cell lines -RSB- .
21964832	0	berberine	10,19	TPA	41,44	berberine	TPA	MESH:D001599	5327	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	Effect of berberine on p53 expression by TPA in breast_cancer cells .
20622114	0	berberine	138,147	Th1	14,17	berberine	Th1	MESH:D001599	51497	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of Th1 and Th17 cell differentiation and amelioration of experimental_autoimmune_encephalomyelitis by natural product compound berberine .
24588674	0	berberine	55,64	Uncoupling_protein-2	0,20	berberine	Uncoupling protein-2	MESH:D001599	54315(Tax:10116)	Chemical	Gene	action|nmod|START_ENTITY mediates|dobj|action mediates|nsubj|END_ENTITY	Uncoupling_protein-2 mediates the protective action of berberine against oxidative stress in rat insulinoma INS-1E cells and in diabetic mouse islets .
26531813	0	berberine	30,39	VCAM-1	109,115	berberine	VCAM-1	MESH:D001599	25361(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|END_ENTITY	The renoprotective effects of berberine and its potential impact on the expression of b-arrestins and ICAM-1 / VCAM-1 in streptozocin induced-diabetic_nephropathy rats .
20056426	0	berberine	60,69	acetylcholinesterase	92,112	berberine	acetylcholinesterase	MESH:D001599	43	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|inhibitors inhibitors|compound|END_ENTITY	Synthesis , biological evaluation , and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors .
10364850	0	berberine	46,55	activator_protein_1	14,33	berberine	activator protein 1	MESH:D001599	3726	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activity activity|amod|END_ENTITY	Inhibition of activator_protein_1 activity by berberine in human hepatoma cells .
15724409	0	berberine	12,21	adiponectin	25,36	berberine	adiponectin	MESH:D001599	9370	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	-LSB- Effects of berberine on adiponectin mRNA expression in 3T3-L1 adipocyte -RSB- .
21536037	0	berberine	22,31	adiponectin	41,52	berberine	adiponectin	MESH:D001599	9370	Chemical	Gene	AMPK|nmod|START_ENTITY Activation|nmod|AMPK promotes|nsubj|Activation promotes|dobj|multimerization multimerization|compound|END_ENTITY	Activation of AMPK by berberine promotes adiponectin multimerization in 3T3-L1 adipocytes .
16475703	0	berberine	84,93	caspase-3	120,129	berberine	caspase-3	MESH:D001599	12367(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nmod|activation activation|nmod|END_ENTITY	Apoptosis of human leukemia HL-60 cells and murine leukemia WEHI-3 cells induced by berberine through the activation of caspase-3 .
10433483	0	berberine	14,23	cyclooxygenase-2	27,43	berberine	cyclooxygenase-2	MESH:D001599	5743	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Inhibition by berberine of cyclooxygenase-2 transcriptional activity in human colon_cancer cells .
14505547	0	berberine	23,32	cyclooxygenase-2	58,74	berberine	cyclooxygenase-2	MESH:D001599	5743	Chemical	Gene	START_ENTITY|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- The inhibit effect of berberine on human colon cell line cyclooxygenase-2 -RSB- .
15796182	0	berberine	27,36	cyclooxygenase-2	59,75	berberine	cyclooxygenase-2	MESH:D001599	5743	Chemical	Gene	apoptosis|nmod|START_ENTITY Modulation|nmod|apoptosis Modulation|nmod|expression expression|amod|END_ENTITY	Modulation of apoptosis by berberine through inhibition of cyclooxygenase-2 and Mcl-1 expression in oral_cancer cells .
21246838	0	berberine	23,32	cyclooxygenase-2	84,100	berberine	cyclooxygenase-2	MESH:D001599	5743	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Preventive effects of berberine on experimental colon_cancer and relationship with cyclooxygenase-2 expression -RSB- .
16133554	0	berberine	11,20	cyclosporin_A	51,64	berberine	cyclosporin A	MESH:D001599	1161	Chemical	Gene	START_ENTITY|nmod|concentration concentration|nmod|END_ENTITY	Effects of berberine on the blood concentration of cyclosporin_A in renal transplanted recipients : clinical and pharmacokinetic study .
19945441	0	berberine	49,58	glucagon-like_peptide-1	14,37	berberine	glucagon-like peptide-1	MESH:D001599	2641	Chemical	Gene	release|nmod|START_ENTITY release|amod|END_ENTITY	Modulation of glucagon-like_peptide-1 release by berberine : in vivo and in vitro studies .
19852296	0	berberine	4,13	insulin	52,59	berberine	insulin	MESH:D001599	3630	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	-LSB- Of berberine and puerarin on dexamethasone-induced insulin resistance in porcine ovarian thecal cells -RSB- .
23866924	0	berberine	10,19	insulin	23,30	berberine	insulin	MESH:D001599	3630	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	Effect of berberine on insulin resistance in women with polycystic_ovary_syndrome : study protocol for a randomized multicenter controlled trial .
16132116	0	berberine	98,107	interleukin-1beta	21,38	berberine	interleukin-1beta	MESH:D001599	3553	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|END_ENTITY	Acetaldehyde-induced interleukin-1beta and tumor_necrosis_factor-alpha production is inhibited by berberine through nuclear_factor-kappaB signaling pathway in HepG2 cells .
16391493	0	berberine	10,19	interleukin_8	23,36	berberine	interleukin 8	MESH:D001599	3576	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of berberine on interleukin_8 and monocyte_chemotactic_protein_1 expression in a human retinal pigment epithelial cell line .
22765939	0	berberine	30,39	lysozyme	55,63	berberine	lysozyme	MESH:D001599	4069	Chemical	Gene	mechanism|nmod|START_ENTITY END_ENTITY|nsubj|mechanism	Interaction mechanism between berberine and the enzyme lysozyme .
17164575	0	berberine	10,19	monocyte_chemotactic_protein-1	23,53	berberine	monocyte chemotactic protein-1	MESH:D001599	24770(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of berberine on monocyte_chemotactic_protein-1 and cytokine-induced_neutrophil_chemoattractant-1 expression in rat lipopolysaccharide-induced uveitis .
21964832	0	berberine	10,19	p53	23,26	berberine	p53	MESH:D001599	7157	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of berberine on p53 expression by TPA in breast_cancer cells .
15638014	0	berberine	11,20	phosphodiesterase_type_5	47,71	berberine	phosphodiesterase type 5	MESH:D001599	171115(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of berberine on the mRNA expression of phosphodiesterase_type_5 -LRB- PDE5 -RRB- in rat corpus cavernosum -RSB- .
17295371	0	berberine	20,29	prolyl_oligopeptidase	41,62	berberine	prolyl oligopeptidase	MESH:D001599	5550	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|compound|END_ENTITY	The natural product berberine is a human prolyl_oligopeptidase inhibitor .
22368864	0	berberine	11,20	transforming_growth_factor-beta1	38,70	berberine	transforming growth factor-beta1	MESH:D001599	59086(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|proteins proteins|amod|END_ENTITY	-LSB- Effect of berberine on expression of transforming_growth_factor-beta1 and type IV collagen proteins in mesangial cells of diabetic rats with nephropathy -RSB- .
23664937	0	berberine_hydrochloride	58,81	P-glycoprotein	85,99	berberine hydrochloride	P-glycoprotein	null	287115(Tax:10116)	Chemical	Gene	START_ENTITY|appos|substrate substrate|amod|END_ENTITY	Effects of b-cyclodextrin on the intestinal absorption of berberine_hydrochloride , a P-glycoprotein substrate .
18357892	0	berberine_hydrochloride	11,34	interleukin-1beta	56,73	berberine hydrochloride	interleukin-1beta	null	24494(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of berberine_hydrochloride on the expression of interleukin-1beta and tumor_necrosis_factor-alpha in periodontal tissues in rats -RSB- .
16797033	0	berberrubine	10,22	interleukin-8	26,39	berberrubine	interleukin-8	MESH:C115958	3576	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effect of berberrubine on interleukin-8 and monocyte_chemotactic_protein-1 expression in human retinal pigment epithelial cell line .
13680837	0	bergenin	31,39	tyrosine_hydroxylase	74,94	bergenin	tyrosine hydroxylase	MESH:C006741	280707(Tax:9913)	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nsubj|effects	In vitro inhibitory effects of bergenin and norbergenin on bovine adrenal tyrosine_hydroxylase .
12620668	0	beryllium	27,36	HLA-DP	88,94	beryllium	HLA-DP	MESH:D001608	3115	Chemical	Gene	modes|nmod|START_ENTITY modes|nmod|END_ENTITY	Potential binding modes of beryllium with the class II major histocompatibility complex HLA-DP : a combined theoretical and structural database study .
23087055	4	beryllium_fluoride	855,873	ATPase	891,897	beryllium fluoride	ABCC10	MESH:C035982	224814(Tax:10090)	Chemical	Gene	START_ENTITY|dep|activity activity|amod|END_ENTITY	Using crude membranes in an ABCC10 overexpression system , we found that the ABCC10 transport substrates estrogen_estradiol-glucuronide -LRB- E -LRB- 2 -RRB- 17bG -RRB- and leukotriene C4 -LRB- LTC -LRB- 4 -RRB- -RRB- significantly stimulated ABCC10 beryllium_fluoride -LRB- BeFx -RRB- - sensitive ATPase activity .
14597989	0	bestatin	25,33	Aminopeptidase	0,14	bestatin	Aminopeptidase	null	10404	Chemical	Gene	stimulates|compound|START_ENTITY stimulates|amod|END_ENTITY	Aminopeptidase inhibitor bestatin stimulates microvascular endothelial cell invasion in a fibrin matrix .
2074619	0	bestatin	26,34	X-linked_muscular_dystrophy	73,100	bestatin	X-linked muscular dystrophy	null	13405(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	The stabilizing effect of bestatin on the resting membrane potentials of X-linked_muscular_dystrophy mice .
1846352	1	bestatin	40,48	aminopeptidase	63,77	bestatin	aminopeptidase	null	10404	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Inhibition by bestatin and intrinsic aminopeptidase activity establish its functional resemblance to metallohydrolase enzymes .
8671253	0	bestatin	29,37	aminopeptidase	3,17	bestatin	aminopeptidase	null	10404	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	An aminopeptidase inhibitor , bestatin , enhances progesterone and oestradiol secretion by porcine granulosa cells stimulated with follicle stimulating hormone in vitro .
9694371	0	bestatin	100,108	aminopeptidase	62,76	bestatin	aminopeptidase	null	3497202(Tax:31271)	Chemical	Gene	growth|nmod|START_ENTITY growth|compound|END_ENTITY	Plasmodium_chabaudi_chabaudi and P. _ falciparum : inhibition of aminopeptidase and parasite growth by bestatin and nitrobestatin .
2083325	0	bestatin	44,52	enkephalin	60,70	bestatin	enkephalin	null	29237(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|level level|compound|END_ENTITY	-LSB- The effect of the aminopeptidase inhibitor bestatin on the enkephalin level in the rat brain -RSB- .
6476836	0	bestatin	11,19	immuno-suppressive_acidic_protein	23,56	bestatin	immuno-suppressive acidic protein	null	3375	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of bestatin on immuno-suppressive_acidic_protein in patients with stomach_cancer -RSB- .
7627841	0	bestrabucil	22,33	androgen-induced_growth_factor	99,129	bestrabucil	androgen-induced growth factor	MESH:C036613	2253	Chemical	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	Inhibitory effects of bestrabucil , a conjugate of chlorambucil and estradiol , on the production of androgen-induced_growth_factor -LRB- s -RRB- by Shionogi carcinoma 115 cells .
8339282	0	beta-Carotene	0,13	ornithine_decarboxylase	38,61	beta-Carotene	ornithine decarboxylase	MESH:D019207	4953	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	beta-Carotene inhibits rectal mucosal ornithine_decarboxylase activity in colon_cancer patients .
8823908	0	beta-D-galactopyranosyl-D-xylopyranosides	32,73	lactase	115,122	beta-D-galactopyranosyl-D-xylopyranosides	lactase	null	116569(Tax:10116)	Chemical	Gene	synthesis|nmod|START_ENTITY END_ENTITY|nsubj|synthesis	A direct enzymatic synthesis of beta-D-galactopyranosyl-D-xylopyranosides and their use to evaluate rat intestinal lactase activity in vivo .
20605788	0	beta-D-glucopyranoside	24,46	hTAS2R16	95,103	beta-D-glucopyranoside	hTAS2R16	null	50833	Chemical	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Characterization of the beta-D-glucopyranoside binding site of the human bitter taste receptor hTAS2R16 .
1516088	0	beta-D-mannosides	13,30	C-2	92,95	beta-D-mannosides	C-2	CHEBI:27507	717	Chemical	Gene	Synthesis|nmod|START_ENTITY Synthesis|nmod|END_ENTITY	Synthesis of beta-D-mannosides from beta-D-glucosides via an intramolecular SN2 reaction at C-2 .
10940375	0	beta-Funaltrexamine	0,19	ORL1	32,36	beta-Funaltrexamine	ORL1	MESH:C024524	4987	Chemical	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	beta-Funaltrexamine inactivates ORL1 receptors in BE -LRB- 2 -RRB- - C human neuroblastoma cells .
18069767	0	beta-L-D4A	24,34	DNA_polymerase_alpha	38,58	beta-L-D4A	DNA polymerase alpha	MESH:C075923	5422	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect and mechanism of beta-L-D4A on DNA_polymerase_alpha .
18314257	0	beta-Sitosterol	0,15	Bcl-2	82,87	beta-Sitosterol	Bcl-2	MESH:C025473	596	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	beta-Sitosterol induces G2/M arrest , endoreduplication , and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways .
17331715	0	beta-aminoacyl-containing_cyclic_hydrazine	65,107	dipeptidyl_peptidase_IV	123,146	beta-aminoacyl-containing cyclic hydrazine	dipeptidyl peptidase IV	null	13482(Tax:10090)	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Synthesis , biological evaluation and structural determination of beta-aminoacyl-containing_cyclic_hydrazine derivatives as dipeptidyl_peptidase_IV -LRB- DPP-IV -RRB- inhibitors .
1680324	0	beta-aminopropionitrile	14,37	elastin	41,48	beta-aminopropionitrile	elastin	MESH:D000629	25043(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|compound|END_ENTITY	The effect of beta-aminopropionitrile on elastin gene expression in smooth muscle cell cultures .
19440335	0	beta-aminopropionitrile	29,52	lysyl_oxidase	4,17	beta-aminopropionitrile	lysyl oxidase	MESH:D000629	4015	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	The lysyl_oxidase inhibitor , beta-aminopropionitrile , diminishes the metastatic colonization potential of circulating breast_cancer cells .
18589755	0	beta-asarone	12,24	FOS	42,45	beta-asarone	FOS	MESH:C012195	314322(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of beta-asarone on expression of FOS and GAD65 in cortex of epileptic rat induced by penicillin -RSB- .
18536377	0	beta-asarone	12,24	c-fos	42,47	beta-asarone	c-fos	MESH:C012195	314322(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of beta-asarone on expression of c-fos in kindling_epilepsy rat brain -RSB- .
3404762	0	beta-carboline_esters	30,51	Cholecystokinin	0,15	beta-carboline esters	Cholecystokinin	null	12424(Tax:10090)	Chemical	Gene	antagonism|nmod|START_ENTITY antagonism|nsubj|END_ENTITY	Cholecystokinin antagonism by beta-carboline_esters in the central nervous system in mice .
6864229	0	beta-carbolines	34,49	acetylcholinesterase	71,91	beta-carbolines	acetylcholinesterase	MESH:D002243	83817(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activities activities|nmod|END_ENTITY	In vitro studies on the effect of beta-carbolines on the activities of acetylcholinesterase and choline_acetyltransferase and on the muscarinic receptor binding of the rat brain .
17692827	0	beta-carbolines	16,31	dopamine_transporter	35,55	beta-carbolines	dopamine transporter	MESH:D002243	6531	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Cytotoxicity of beta-carbolines in dopamine_transporter expressing cells : structure-activity relationships .
14660022	0	beta-carbolines	15,30	insulin	57,64	beta-carbolines	insulin	MESH:D002243	3630	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of the beta-carbolines , harmane and pinoline , on insulin secretion from isolated human islets of Langerhans .
15860445	0	beta-carotene	67,80	BAX	46,49	beta-carotene	BAX	MESH:D019207	581	Chemical	Gene	effects|amod|START_ENTITY mediator|nmod|effects END_ENTITY|nmod|mediator	The microarray expression analysis identifies BAX as a mediator of beta-carotene effects on apoptosis .
20472610	0	beta-carotene	104,117	Fzd6	18,22	beta-carotene	Fzd6	MESH:D019207	14368(Tax:10090)	Chemical	Gene	Downregulation|nmod|START_ENTITY Downregulation|nmod|END_ENTITY	Downregulation of Fzd6 and Cthrc1 and upregulation of olfactory receptors and protocadherins by dietary beta-carotene in lungs of Bcmo1 - / - mice .
23917457	0	beta-carotene	10,23	connexin_43	70,81	beta-carotene	connexin 43	MESH:D019207	24392(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of beta-carotene on oxidative stress and expression of cardiac connexin_43 .
1298124	0	beta-carotene	15,28	interleukin-2	32,45	beta-carotene	interleukin-2	MESH:D019207	16183(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	-LSB- The effect of beta-carotene on interleukin-2 production and mitogen-induced proliferation of T-lymphocytes -RSB- .
11741586	0	beta-carotene	14,27	interleukin-6	49,62	beta-carotene	interleukin-6	MESH:D019207	3569	Chemical	Gene	START_ENTITY|nmod|expression expression|acl|END_ENTITY	The effect of beta-carotene on the expression of interleukin-6 and heme_oxygenase-1 in UV-irradiated human skin fibroblasts in vitro .
10759853	0	beta-carotene	32,45	p21waf1/cip1	55,67	beta-carotene	p21waf1/cip1	MESH:D019207	1026	Chemical	Gene	effect|nmod|START_ENTITY requires|nsubj|effect requires|dobj|END_ENTITY	The antiproliferative effect of beta-carotene requires p21waf1/cip1 in normal human fibroblasts .
20171758	0	beta-chloro_vinyl_chalcones	39,66	TNF-alpha	84,93	beta-chloro vinyl chalcones	TNF-alpha	null	7124	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Synthesis and biological evaluation of beta-chloro_vinyl_chalcones as inhibitors of TNF-alpha and IL-6 with antimicrobial activity .
15005607	0	beta-cyclodextrin-heptagastrin	49,79	cholecystokinin_2_receptor	120,146	beta-cyclodextrin-heptagastrin	cholecystokinin 2 receptor	null	887	Chemical	Gene	studies|nmod|START_ENTITY studies|nmod|END_ENTITY	Conformational and molecular modeling studies of beta-cyclodextrin-heptagastrin and the third extracellular loop of the cholecystokinin_2_receptor .
19674910	0	beta-diketones	21,35	TNF-alpha	65,74	beta-diketones	TNF-alpha	CHEBI:67265	7124	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Inhibitory effect of beta-diketones and their metal complexes on TNF-alpha induced expression of ICAM-1 on human endothelial cells .
18983771	0	beta-elemene	11,23	angiotensin_II	113,127	beta-elemene	angiotensin II	MESH:C445979	183	Chemical	Gene	Effect|nmod|START_ENTITY induced|nsubj|Effect induced|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Effect of beta-elemene on the proliferation , migration and RhoA expression of hepatic stellate cells induced by angiotensin_II -RSB- .
6293986	0	beta-endorphinyl-thiolglycine	19,48	beta-endorphin	104,118	beta-endorphinyl-thiolglycine	beta-endorphin	null	5443	Chemical	Gene	Synthesis|nmod|START_ENTITY Synthesis|nmod|END_ENTITY	Synthesis of human beta-endorphinyl-thiolglycine and its use for the preparation of affinity columns of beta-endorphin .
17362937	0	beta-estradiol	62,76	CXCR4	28,33	beta-estradiol	CXCR4	CHEBI:16469	7852	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Epigenetic up-regulation of CXCR4 and CXCL12 expression by 17 beta-estradiol and tamoxifen is associated with formation of DNA_methyltransferase_3B4 splice variant in Ishikawa endometrial_adenocarcinoma cells .
11743650	0	beta-estradiol	40,54	Frizzled-10	17,28	beta-estradiol	Frizzled-10	CHEBI:16469	11211	Chemical	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|END_ENTITY	Up-regulation of Frizzled-10 -LRB- FZD10 -RRB- by beta-estradiol in MCF-7 cells and by retinoic_acid in NT2 cells .
12239602	0	beta-estradiol	95,109	WNT10B	70,76	beta-estradiol	WNT10B	CHEBI:16469	7480	Chemical	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	Expression and regulation of WNT10B in human cancer : up-regulation of WNT10B in MCF-7 cells by beta-estradiol and down-regulation of WNT10B in NT2 cells by retinoic_acid .
11956596	0	beta-estradiol	109,123	WNT8B	95,100	beta-estradiol	WNT8B	CHEBI:16469	7479	Chemical	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	Expression and regulation of WNT8A and WNT8B mRNAs in human tumor cell lines : up-regulation of WNT8B mRNA by beta-estradiol in MCF-7 cells , and down-regulation of WNT8A and WNT8B mRNAs by retinoic_acid in NT2 cells .
3780551	0	beta-estradiol	14,28	angiotensin_II	32,46	beta-estradiol	angiotensin II	CHEBI:16469	24179(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|receptors receptors|amod|END_ENTITY	Effects of 17 beta-estradiol on angiotensin_II receptors and prolactin release in cultured pituitary cells .
14501156	0	beta-estradiol	14,28	calcitonin_gene-related_peptide	113,144	beta-estradiol	calcitonin gene-related peptide	CHEBI:16469	24241(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|release release|nmod|END_ENTITY	Effects of 17 beta-estradiol and the Japanese herbal medicine Keishi-bukuryo-gan on the release and synthesis of calcitonin_gene-related_peptide in ovariectomized rats .
1541679	0	beta-estradiol	3,17	interleukin-6	27,40	beta-estradiol	interleukin-6	CHEBI:16469	16193(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	17 beta-estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in vitro : a potential mechanism for the antiosteoporotic effect of estrogens .
10460832	0	beta-galactoside	21,37	SIAT1	71,76	beta-galactoside	SIAT1	MESH:C007816	6480	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Transcription of the beta-galactoside alpha2,6-sialyltransferase gene -LRB- SIAT1 -RRB- in B-lymphocytes : cell type-specific expression correlates with presence of the divergent 5 ' - untranslated sequence .
2494945	0	beta-glycerophosphate	15,36	glycogen_phosphorylase_b	40,64	beta-glycerophosphate	glycogen phosphorylase b	MESH:C031463	5834	Chemical	Gene	binding|nmod|START_ENTITY binding|acl|END_ENTITY	The binding of beta-glycerophosphate to glycogen_phosphorylase_b in the crystal .
22383088	0	beta-glycerophosphate_disodium	94,124	ERK	166,169	beta-glycerophosphate disodium	ERK	null	5594	Chemical	Gene	START_ENTITY|nmod|pathway pathway|compound|END_ENTITY	Taurine suppresses osteoblastic differentiation of aortic valve interstitial cells induced by beta-glycerophosphate_disodium , dexamethasone and ascorbic_acid via the ERK pathway .
19358571	0	beta-guanidinopropionic_acid	41,69	hPAT1	136,141	beta-guanidinopropionic acid	hPAT1	MESH:C005775	206358	Chemical	Gene	transported|nsubjpass|START_ENTITY transported|nmod|END_ENTITY	The orally active antihyperglycemic drug beta-guanidinopropionic_acid is transported by the human proton-coupled amino_acid transporter hPAT1 .
1868844	0	beta-hydroxy	67,79	estrogen_receptor	113,130	beta-hydroxy	estrogen receptor	null	2099	Chemical	Gene	interactions|nmod|START_ENTITY interactions|nmod|END_ENTITY	Differential interactions of estrogens and antiestrogens at the 17 beta-hydroxy or counterpart function with the estrogen_receptor .
18840762	0	beta-hydroxy-beta-methylbutyrate	116,148	tumor_necrosis_factor-alpha	66,93	beta-hydroxy-beta-methylbutyrate	tumor necrosis factor-alpha	MESH:C004961	21926(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nmod|END_ENTITY	Mechanism of attenuation of muscle protein degradation induced by tumor_necrosis_factor-alpha and angiotensin_II by beta-hydroxy-beta-methylbutyrate .
6130018	0	beta-hydroxybutyrate	22,42	somatostatin	61,73	beta-hydroxybutyrate	somatostatin	MESH:D020155	403993(Tax:9615)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Stimulatory effect of beta-hydroxybutyrate on the release of somatostatin from the isolated pancreas of normal and streptozotocin-diabetic dogs .
14621981	0	beta-ionone	35,46	rhodopsin	66,75	beta-ionone	rhodopsin	MESH:C008157	509933(Tax:9913)	Chemical	Gene	region|amod|START_ENTITY region|nmod|END_ENTITY	Conformational similarities in the beta-ionone ring region of the rhodopsin chromophore in its ground state and after photoactivation to the metarhodopsin-I intermediate .
15506754	0	beta-lactam	40,51	BlaR1	69,74	beta-lactam	BlaR1	CHEBI:35627	13877880	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	X-ray crystal structure of the acylated beta-lactam sensor domain of BlaR1 from Staphylococcus_aureus and the mechanism of receptor activation for signal transduction .
9629537	0	beta-lactam	2,13	cytosolic_phospholipase_A2	27,53	beta-lactam	cytosolic phospholipase A2	CHEBI:35627	5321	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|nmod|END_ENTITY	A beta-lactam inhibitor of cytosolic_phospholipase_A2 which acts in a competitive , reversible manner at the lipid/water interface .
7608910	0	beta-lactam	14,25	human_leukocyte_elastase	40,64	beta-lactam	human leukocyte elastase	CHEBI:35627	1991	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Orally active beta-lactam inhibitors of human_leukocyte_elastase .
11937339	0	beta-lactam	52,63	prostate-specific_antigen	97,122	beta-lactam	prostate-specific antigen	CHEBI:35627	354	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|nmod|END_ENTITY	Efficient and highly stereoselective synthesis of a beta-lactam inhibitor of the serine_protease prostate-specific_antigen .
16239287	0	beta-lactams	24,36	IFN-gamma	46,55	beta-lactams	IFN-gamma	MESH:D047090	3458	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activity activity|amod|END_ENTITY	Differential effects of beta-lactams on human IFN-gamma activity .
18633302	0	beta-mercaptoethanol	11,31	proinsulin	87,97	beta-mercaptoethanol	proinsulin	CHEBI:41218	3630	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of beta-mercaptoethanol and hydrogen_peroxide on enzymatic conversion of human proinsulin to insulin .
6287677	0	beta-naphthoflavone	52,71	Ah-receptor	95,106	beta-naphthoflavone	Ah-receptor	MESH:D019324	11622(Tax:10090)	Chemical	Gene	START_ENTITY|appos|ligand ligand|nmod|END_ENTITY	TCDD embryotoxicity in the mouse may be enhanced by beta-naphthoflavone , another ligand of the Ah-receptor .
9299598	0	beta-naphthoflavone	19,38	CYP1A	0,5	beta-naphthoflavone	CYP1A	MESH:D019324	140634(Tax:7955)	Chemical	Gene	induction|nmod|START_ENTITY induction|nsubj|END_ENTITY	CYP1A induction by beta-naphthoflavone , Aroclor_1254 , and 2,3,7,8-tetrachlorodibenzo-p-dioxin and its influence on aflatoxin_B1 metabolism and DNA adduction in zebrafish .
19464568	0	beta-naphthoflavone	51,70	CYP1A1	31,37	beta-naphthoflavone	CYP1A1	MESH:D019324	403103(Tax:9823)	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression and inducibility of CYP1A1 , 1A2 , 1B1 by beta-naphthoflavone and CYP2B22 , 3A22 , 3A29 , 3A46 by rifampicin in the respiratory_and_olfactory_mucosa of pig .
19786062	0	beta-naphthoflavone	10,29	CYP1A1	54,60	beta-naphthoflavone	CYP1A1	MESH:D019324	403103(Tax:9823)	Chemical	Gene	START_ENTITY|nmod|genes genes|dep|END_ENTITY	Effect of beta-naphthoflavone on AhR-regulated genes -LRB- CYP1A1 , 1A2 , 1B1 , 2S1 , Nrf2 , and GST -RRB- and antioxidant enzymes in various brain regions of pig .
17011724	0	beta-naphthoflavone	70,89	MDR1	150,154	beta-naphthoflavone	MDR1	MESH:D019324	5243	Chemical	Gene	gene|nmod|START_ENTITY down-regulation|nmod|gene down-regulation|dep|hypothesis hypothesis|acl|linking linking|dobj|induction induction|nmod|inhibition inhibition|compound|END_ENTITY	Significant transcriptional down-regulation of the human MDR1 gene by beta-naphthoflavone : a proposed hypothesis linking potent CYP gene induction to MDR1 inhibition .
17011724	0	beta-naphthoflavone	70,89	MDR1	57,61	beta-naphthoflavone	MDR1	MESH:D019324	5243	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Significant transcriptional down-regulation of the human MDR1 gene by beta-naphthoflavone : a proposed hypothesis linking potent CYP gene induction to MDR1 inhibition .
2832720	0	beta-naphthoflavone	11,30	insulin_receptor	34,50	beta-naphthoflavone	insulin receptor	MESH:D019324	24954(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|binding binding|compound|END_ENTITY	Effects of beta-naphthoflavone on insulin_receptor binding and protein kinase activity in rat liver and placenta .
16376544	0	beta-phenethylamine	24,43	DPP-IV	58,64	beta-phenethylamine	DPP-IV	MESH:C029261	1803	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	The reversed binding of beta-phenethylamine inhibitors of DPP-IV : X-ray structures and properties of novel fragment and elaborated inhibitors .
18602830	0	beta-phenethylamines	36,56	trace_amine_receptor_1	66,88	beta-phenethylamines	trace amine receptor 1	null	134864	Chemical	Gene	correlations|nmod|START_ENTITY correlations|nmod|END_ENTITY	Structure-activity correlations for beta-phenethylamines at human trace_amine_receptor_1 .
18992226	0	beta-sitosterol	22,37	AMP-activated_protein_kinase	106,134	beta-sitosterol	AMP-activated protein kinase	MESH:C025473	5563	Chemical	Gene	effects|nmod|START_ENTITY mediated|nsubjpass|effects mediated|nmod|END_ENTITY	Beneficial effects of beta-sitosterol on glucose and lipid metabolism in L6 myotube cells are mediated by AMP-activated_protein_kinase .
17341120	0	beta-tetraethyl-substituted_dipyrrolyldiketones	17,64	BF2	0,3	beta-tetraethyl-substituted dipyrrolyldiketones	BF2	null	2290	Chemical	Gene	complexes|nmod|START_ENTITY complexes|nummod|END_ENTITY	BF2 complexes of beta-tetraethyl-substituted_dipyrrolyldiketones as anion receptors : potential building subunits for oligomeric systems .
15980243	0	betaB3-crystallin_peptide	19,44	betaB2-crystallin	88,105	betaB3-crystallin peptide	betaB2-crystallin	null	287011(Tax:9913)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|interaction interaction|nmod|END_ENTITY	Effect of oxidized betaB3-crystallin_peptide on lens betaL-crystallin : interaction with betaB2-crystallin .
22053950	0	betaine	11,18	GABA_transporter_2	98,116	betaine	GABA transporter 2	MESH:D001622	14411(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of betaine on lipopolysaccharide-induced memory_impairment in mice and the involvement of GABA_transporter_2 .
16586540	0	betaine	11,18	IGF-I	54,59	betaine	IGF-I	MESH:D001622	24482(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|nmod|END_ENTITY	Effects of betaine on ethanol-stimulated secretion of IGF-I and IGFBP-1 in rat primary hepatocytes : involvement of p42/44 MAPK activation .
6827372	0	betaine	72,79	betaine-homocysteine_methyltransferase	22,60	betaine	betaine-homocysteine methyltransferase	MESH:D001622	81508(Tax:10116)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of hepatic betaine-homocysteine_methyltransferase by dietary betaine .
15162365	0	betaine	11,18	mucin	47,52	betaine	mucin	MESH:D001622	100508689	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|release release|compound|END_ENTITY	Effects of betaine , coumarin and flavonoids on mucin release from cultured hamster tracheal surface epithelial cells .
19642983	0	betaine	28,35	p16	39,42	betaine	p16	MESH:D001622	25163(Tax:10116)	Chemical	Gene	Assessment|nmod|START_ENTITY Assessment|nmod|END_ENTITY	Assessment of the effect of betaine on p16 and c-myc DNA methylation and mRNA expression in a chemical induced rat liver_cancer model .
25080425	0	betaine	91,98	signal_transducer_and_activator_of_transcription_3	14,64	betaine	signal transducer and activator of transcription 3	MESH:D001622	25125(Tax:10116)	Chemical	Gene	pathways|nmod|START_ENTITY pathways|amod|END_ENTITY	Regulation of signal_transducer_and_activator_of_transcription_3 and apoptotic pathways by betaine attenuates isoproterenol-induced acute myocardial_injury in rats .
3873877	0	betamethasone	10,23	IgE	59,62	betamethasone	IgE	MESH:D001623	3497	Chemical	Gene	START_ENTITY|nmod|reaction reaction|nmod|END_ENTITY	Effect of betamethasone on the dual reaction to anti-human IgE in man : influence of time interval between administration of drug and anti-IgE .
11158279	0	betamethasone	20,33	MAP1B	79,84	betamethasone	MAP1B	MESH:D001623	101116509	Chemical	Gene	treatment|compound|START_ENTITY treatment|nmod|END_ENTITY	Effect of antenatal betamethasone treatment on microtubule-associated proteins MAP1B and MAP2 in fetal sheep .
16889992	0	betamethasone	10,23	adrenomedullin	45,59	betamethasone	adrenomedullin	MESH:D001623	133	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of betamethasone in vivo on placental adrenomedullin in human pregnancy .
3754194	0	betamethasone	15,28	calcium_binding_protein	54,77	betamethasone	calcium binding protein	MESH:D001623	397265(Tax:9823)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of betamethasone on plasma and intestinal calcium_binding_protein and on 25-hydroxyvitamin_D3 metabolism in the pig .
9579442	0	betamethasone	10,23	corticotropin-releasing_hormone	45,76	betamethasone	corticotropin-releasing hormone	MESH:D001623	1392	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of betamethasone in vivo on placental corticotropin-releasing_hormone in human pregnancy .
1103754	0	betamethasone	60,73	glucose-6-phosphate_dehydrogenase	14,47	betamethasone	glucose-6-phosphate dehydrogenase	MESH:D001623	2539	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Inhibition of glucose-6-phosphate_dehydrogenase activity by betamethasone and three of its esters with dermatological importance .
16984797	0	betamethasone	21,34	matrix_metalloproteinases_2_and_9	65,98	betamethasone	matrix metalloproteinases 2 and 9	MESH:D001623	4313;4318	Chemical	Gene	START_ENTITY|nmod|activities activities|amod|END_ENTITY	Effects of antenatal betamethasone on maternal and fetoplacental matrix_metalloproteinases_2_and_9 activities in human singleton pregnancies .
20453526	0	betamethasone	21,34	vascular_endothelial_growth_factor	79,113	betamethasone	vascular endothelial growth factor	MESH:D001623	83785(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of antenatal betamethasone and dexamethasone on the lung expression of vascular_endothelial_growth_factor and alveolarization in newborn rats exposed to acute hypoxia and recovered in normoxia or hyperoxia .
2884312	0	betaxolol	46,55	beta_1-adrenoceptor	63,82	betaxolol	beta 1-adrenoceptor	MESH:D015784	153	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Synthesis of a series of compounds related to betaxolol , a new beta_1-adrenoceptor antagonist with a pharmacological and pharmacokinetic profile optimized for the treatment of chronic cardiovascular_diseases .
1675576	0	betaxolol	91,100	beta_2-adrenoceptor	57,76	betaxolol	beta 2-adrenoceptor	MESH:D015784	154	Chemical	Gene	antagonism|nmod|START_ENTITY antagonism|amod|END_ENTITY	The effects of time and dose on the relative beta 1 - and beta_2-adrenoceptor antagonism of betaxolol and atenolol .
842531	0	bethanechol	10,21	gastroesophageal_reflux	25,48	bethanechol	gastroesophageal reflux	MESH:D018723	59330	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of bethanechol on gastroesophageal_reflux .
19132191	0	betrixaban	27,37	factor_Xa	47,56	betrixaban	factor Xa	MESH:C543086	2159	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	A randomized evaluation of betrixaban , an oral factor_Xa inhibitor , for prevention of thromboembolic events after total knee replacement -LRB- EXPERT -RRB- .
20037601	0	betulinic_acid	10,24	Hiwi	46,50	betulinic acid	Hiwi	MESH:C002070	9271	Chemical	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Effect of betulinic_acid on the regulation of Hiwi and cyclin_B1 in human gastric_adenocarcinoma AGS cells .
23857605	0	betulinic_acid	42,56	Lamin_B1	0,8	betulinic acid	Lamin B1	MESH:C002070	4001	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Lamin_B1 is a novel therapeutic target of betulinic_acid in pancreatic_cancer .
23256448	0	betulinic_acid	22,36	PTP1B	40,45	betulinic acid	PTP1B	MESH:C002070	19246(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Combined treatment of betulinic_acid , a PTP1B inhibitor , with Orthosiphon stamineus extract decreases body weight in high-fat-fed mice .
2858236	0	bevantolol	26,36	beta_1-adrenoceptor	50,69	bevantolol	beta 1-adrenoceptor	MESH:C021148	24925(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|antagonist antagonist|amod|END_ENTITY	Cardiovascular effects of bevantolol , a selective beta_1-adrenoceptor antagonist with a novel pharmacological profile .
6148733	0	bevantolol_hydrochloride	15,39	beta_1-adrenoceptor	43,62	bevantolol hydrochloride	beta 1-adrenoceptor	MESH:C021148	153	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Selectivity of bevantolol_hydrochloride , a beta_1-adrenoceptor antagonist , in asthmatic patients .
18405181	0	bexarotene	10,20	CD30	47,51	bexarotene	CD30	MESH:C095105	943	Chemical	Gene	monotherapy|compound|START_ENTITY monotherapy|nmod|END_ENTITY	Long-term bexarotene monotherapy in large cell CD30 + pleomorphic T-cell_lymphoma .
19845753	0	bexarotene	31,41	CTCL	45,49	bexarotene	CTCL	MESH:C095105	64061	Chemical	Gene	START_ENTITY|nmod|patients patients|amod|END_ENTITY	About the cutaneous targets of bexarotene in CTCL patients .
19791803	0	bexarotene	204,214	retinoid_X_receptor	59,78	bexarotene	retinoid X receptor	MESH:C095105	6256	Chemical	Gene	benzoic_acid|dep|START_ENTITY -RSB-|amod|benzoic_acid 1|dep|-RSB- evaluation|dep|1 evaluation|nmod|END_ENTITY	Modeling , synthesis and biological evaluation of potential retinoid_X_receptor -LRB- RXR -RRB- selective agonists : novel analogues of 4 - -LSB- 1 - -LRB- 3,5,5,8,8-pentamethyl-5 ,6,7,8 - tetrahydro-2-naphthyl -RRB- ethynyl -RSB- benzoic_acid -LRB- bexarotene -RRB- .
21585279	0	bexarotene	97,107	retinoid_X_receptor	68,87	bexarotene	retinoid X receptor	MESH:C095105	6256	Chemical	Gene	START_ENTITY|nsubj|treatment treatment|nmod|angioimmunoblastic_T-cell_lymphoma angioimmunoblastic_T-cell_lymphoma|nmod|agonist agonist|compound|END_ENTITY	Successful treatment of angioimmunoblastic_T-cell_lymphoma with the retinoid_X_receptor agonist , bexarotene .
24180745	0	bexarotene	205,215	retinoid_X_receptor	60,79	bexarotene	retinoid X receptor	MESH:C095105	6256	Chemical	Gene	benzoic_acid|dep|START_ENTITY -RSB-|amod|benzoic_acid 1|dep|-RSB- evaluation|dep|1 evaluation|nmod|END_ENTITY	Modeling , synthesis , and biological evaluation of potential retinoid_X_receptor -LRB- RXR -RRB- selective agonists : novel analogues of 4 - -LSB- 1 - -LRB- 3,5,5,8,8-pentamethyl-5 ,6,7,8 - tetrahydro-2-naphthyl -RRB- ethynyl -RSB- benzoic_acid -LRB- bexarotene -RRB- and -LRB- E -RRB- -3 - -LRB- 3 - -LRB- 1,2,3,4-tetrahydro-1 ,1,4,4,6 - pentamethylnaphthalen-7-yl -RRB- -4 - hydroxyphenyl -RRB- acrylic_acid -LRB- CD3254 -RRB- .
14700480	0	bexarotene	28,38	retinoid_x_receptor	42,61	bexarotene	retinoid x receptor	MESH:C095105	6256	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Placebo-controlled trial of bexarotene , a retinoid_x_receptor agonist , as maintenance therapy for patients treated with chemotherapy for advanced non-small-cell_lung_cancer .
8871265	0	bezafibrate	10,21	APO_A-I	34,41	bezafibrate	APO A-I	MESH:D001629	335	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of bezafibrate on HDL with APO_A-I and APO_A-II and on HDL with APO_A-I without APO_A-II in hyperlipidaemic patients .
9493704	0	bezafibrate	38,49	HDL3	27,31	bezafibrate	HDL3	MESH:D001629	53369	Chemical	Gene	treatment|amod|START_ENTITY END_ENTITY|nmod|treatment	Physicochemical changes in HDL3 after bezafibrate treatment : influence on free cholesterol efflux from human fibroblasts .
3401284	0	bezafibrate	36,47	fibrinogen	58,68	bezafibrate	fibrinogen	MESH:D001629	2244	Chemical	Gene	treatment|nmod|START_ENTITY Effect|nmod|treatment Effect|nmod|END_ENTITY	Effect of short-term treatment with bezafibrate on plasma fibrinogen , fibrinopeptide A , platelet activation and blood filterability in atherosclerotic_hyperfibrinogenemic patients .
11288046	0	bezafibrate	11,22	insulin	26,33	bezafibrate	insulin	MESH:D001629	3630	Chemical	Gene	START_ENTITY|nmod|sensitivity sensitivity|compound|END_ENTITY	Effects of bezafibrate on insulin sensitivity and insulin secretion in non-obese Japanese type 2 diabetic patients .
1458771	0	bezafibrate	11,22	insulin	26,33	bezafibrate	insulin	MESH:D001629	3630	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|sensitivity sensitivity|compound|END_ENTITY	Effects of bezafibrate on insulin sensitivity and glucose tolerance in subjects with combined hyperlipidemia .
16606809	0	bezafibrate	93,104	insulin	30,37	bezafibrate	insulin	MESH:D001629	3630	Chemical	Gene	Attenuation|nmod|START_ENTITY Attenuation|nmod|resistance resistance|compound|END_ENTITY	Attenuation of progression of insulin resistance in patients with coronary_artery_disease by bezafibrate .
2653325	0	bezafibrate	11,22	insulin	26,33	bezafibrate	insulin	MESH:D001629	3630	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of bezafibrate on insulin secretion and peripheral_insulin_sensitivity in hyperlipidemic patients with and without diabetes .
10628360	0	bezafibrate	40,51	lipoprotein_lipase	10,28	bezafibrate	lipoprotein lipase	MESH:D001629	16956(Tax:10090)	Chemical	Gene	Effect|amod|START_ENTITY Effect|nmod|activators activators|amod|END_ENTITY	Effect of lipoprotein_lipase activators bezafibrate and NO-1886 , on B16 melanoma-induced cachexia in mice .
11164425	0	bezafibrate	28,39	lipoprotein_lipase	103,121	bezafibrate	lipoprotein lipase	MESH:D001629	4023	Chemical	Gene	therapy|amod|START_ENTITY action|nmod|therapy mediated|nsubjpass|action mediated|nmod|upregulation upregulation|nmod|END_ENTITY	The hypolipidemic action of bezafibrate therapy in hypertriglyceridemia is mediated by upregulation of lipoprotein_lipase : no effects on VLDL substrate affinity to lipolysis or LDL_receptor binding .
8147947	0	bezafibrate	26,37	lipoprotein_lipase	41,59	bezafibrate	lipoprotein lipase	MESH:D001629	4023	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effects of treatment with bezafibrate on lipoprotein_lipase activity and mass in patients with hypertriglyceridemia .
8919277	0	bezafibrate	111,122	lipoprotein_lipase	25,43	bezafibrate	lipoprotein lipase	MESH:D001629	4023	Chemical	Gene	START_ENTITY|nsubj|Stimulation Stimulation|nmod|activity activity|amod|END_ENTITY	Stimulation of decreased lipoprotein_lipase activity in the tumor-bearing state by the antihyperlipidemic drug bezafibrate .
18712055	0	bezafibrate	56,67	low-density_lipoprotein_receptor	71,103	bezafibrate	low-density lipoprotein receptor	MESH:D001629	16835(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Cholesterol_reduction and atherosclerosis inhibition by bezafibrate in low-density_lipoprotein_receptor knockout mice .
17521298	0	bezafibrate	68,79	peroxisome_proliferator-activated_receptor-alpha	10,58	bezafibrate	peroxisome proliferator-activated receptor-alpha	MESH:D001629	25747(Tax:10116)	Chemical	Gene	Effect|appos|START_ENTITY Effect|nmod|agonist agonist|amod|END_ENTITY	Effect of peroxisome_proliferator-activated_receptor-alpha agonist -LRB- bezafibrate -RRB- on gastric secretion and gastric cytoprotection in rats .
12492108	0	biaryl_hydroxamate	110,128	histone_deacetylase	142,161	biaryl hydroxamate	histone deacetylase	null	9734	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|nmod|END_ENTITY	Transforming_growth_factor_beta mimetics : discovery of 7 - -LSB- 4 - -LRB- 4-cyanophenyl -RRB- phenoxy -RSB- - heptanohydroxamic_acid , a biaryl_hydroxamate inhibitor of histone_deacetylase .
16887348	0	biarylethers	68,80	melanin-concentrating_hormone_receptor-1	84,124	biarylethers	melanin-concentrating hormone receptor-1	null	2847	Chemical	Gene	START_ENTITY|nmod|antagonists antagonists|amod|END_ENTITY	Solid-phase synthesis and structure-activity relationships of novel biarylethers as melanin-concentrating_hormone_receptor-1 antagonists .
25697265	0	biaryltriazoles	50,65	macrophage_migration_inhibitory_factor	102,140	biaryltriazoles	macrophage migration inhibitory factor	null	4282	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Design , synthesis , and protein crystallography of biaryltriazoles as potent tautomerase inhibitors of macrophage_migration_inhibitory_factor .
9076469	0	bicalutamide	137,149	Androgen_receptor	0,17	bicalutamide	Androgen receptor	MESH:C053541	367	Chemical	Gene	Casodex|appos|START_ENTITY monotherapy|nmod|Casodex prostate_cancer|nmod|monotherapy prostate_cancer|nsubj|amplification amplification|amod|END_ENTITY	Androgen_receptor gene amplification in a recurrent prostate_cancer after monotherapy with the nonsteroidal potent antiandrogen Casodex -LRB- bicalutamide -RRB- with a subsequent favorable response to maximal androgen blockade .
12053021	0	bicalutamide	104,116	Prostate-specific_antigen	0,25	bicalutamide	Prostate-specific antigen	MESH:C053541	354	Chemical	Gene	castration|amod|START_ENTITY treated|nmod|castration advanced_prostate_cancer|acl|treated predict|nmod|advanced_prostate_cancer predict|nsubj|dynamics dynamics|amod|END_ENTITY	Prostate-specific_antigen dynamics predict risk of progression in advanced_prostate_cancer treated with bicalutamide plus castration .
22369348	0	bicalutamide	88,100	Prostate-specific_antigen	0,25	bicalutamide	Prostate-specific antigen	MESH:C053541	354	Chemical	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Prostate-specific_antigen response to deferred combined_androgen_blockade therapy using bicalutamide predicts survival after subsequent oestrogen and docetaxel therapies in patients with castration-resistant_prostate_cancer .
22369480	1	bicalutamide	107,119	Prostate-specific_antigen	19,44	bicalutamide	Prostate-specific antigen	MESH:C053541	354	Chemical	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Prostate-specific_antigen response to deferred combined androgen blockade therapy using bicalutamide predicts survival after subsequent oestrogen and docetaxel therapies in patients with castration-resistant prostate_cancer .
17596848	0	bicalutamide	32,44	TrkA	66,70	bicalutamide	TrkA	MESH:C053541	4914	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	In vitro and in vivo effects of bicalutamide on the expression of TrkA and P75 neurotrophin receptors in prostate_carcinoma .
12517791	0	bicalutamide	62,74	androgen_receptor	19,36	bicalutamide	androgen receptor	MESH:C053541	367	Chemical	Gene	withdrawal_syndrome|amod|START_ENTITY mechanism|nmod|withdrawal_syndrome mutations|dep|mechanism mutations|nmod|END_ENTITY	Novel mutations of androgen_receptor : a possible mechanism of bicalutamide withdrawal_syndrome .
16302272	0	bicalutamide	109,121	androgen_receptor	4,21	bicalutamide	androgen receptor	MESH:C053541	367	Chemical	Gene	treatment|nmod|START_ENTITY generated|nmod|treatment cells|acl|generated by-passed|nmod|cells by-passed|nsubj|END_ENTITY	The androgen_receptor pathway is by-passed in prostate_cancer cells generated after prolonged treatment with bicalutamide .
19790234	0	bicalutamide	13,25	androgen_receptor	110,127	bicalutamide	androgen receptor	MESH:C053541	367	Chemical	Gene	Induction|nmod|START_ENTITY sensitivity|nsubj|Induction sensitivity|nmod|decrease decrease|nmod|levels levels|compound|END_ENTITY	Induction of bicalutamide sensitivity in prostate_cancer cells by an epigenetic Puralpha-mediated decrease in androgen_receptor levels .
20058237	0	bicalutamide	25,37	androgen_receptor	46,63	bicalutamide	androgen receptor	MESH:C053541	11835(Tax:10090)	Chemical	Gene	treatment|nmod|START_ENTITY induces|nsubj|treatment induces|dobj|overexpression overexpression|amod|END_ENTITY	Prolonged treatment with bicalutamide induces androgen_receptor overexpression and androgen hypersensitivity .
20878136	0	bicalutamide	17,29	androgen_receptor	44,61	bicalutamide	androgen receptor	MESH:C053541	367	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	The antiandrogen bicalutamide activates the androgen_receptor -LRB- AR -RRB- with a mutation in codon 741 through the mitogen_activated_protein_kinase -LRB- MARK -RRB- pathway in human prostate_cancer PC3 cells .
21466228	0	bicalutamide	45,57	androgen_receptor	13,30	bicalutamide	androgen receptor	MESH:C053541	367	Chemical	Gene	antagonism|nmod|START_ENTITY antagonism|nsubj|Mechanism Mechanism|nmod|END_ENTITY	Mechanism of androgen_receptor antagonism by bicalutamide in the treatment of prostate_cancer .
24682014	0	bicalutamide	55,67	androgen_receptor	87,104	bicalutamide	androgen receptor	MESH:C053541	367	Chemical	Gene	studying|dobj|START_ENTITY analysis|acl|studying analogs|nsubj|analysis analogs|xcomp|binding binding|xcomp|END_ENTITY	Optical biosensor analysis in studying new synthesized bicalutamide analogs binding to androgen_receptor .
10963494	0	bicalutamide	53,65	prostate-specific_antigen	13,38	bicalutamide	prostate-specific antigen	MESH:C053541	354	Chemical	Gene	phenomenon|amod|START_ENTITY Undetectable|nmod|phenomenon Undetectable|dobj|response response|amod|END_ENTITY	Undetectable prostate-specific_antigen response with bicalutamide withdrawal phenomenon .
11569230	0	bicalutamide	50,62	prostate-specific_antigen	12,37	bicalutamide	prostate-specific antigen	MESH:C053541	354	Chemical	Gene	Changes|appos|START_ENTITY Changes|nmod|END_ENTITY	-LSB- Changes in prostate-specific_antigen in casodex -LRB- bicalutamide -RRB- monotherapy in a dose 150 mg/day given to patients with locally advanced and/or advanced prostatic_cancer -RSB- .
19336728	0	bicalutamide	27,39	prostate-specific_antigen	61,86	bicalutamide	prostate-specific antigen	MESH:C053541	354	Chemical	Gene	trial|nmod|START_ENTITY I-II|dobj|trial I-II|nmod|men men|nmod|END_ENTITY	Phase I-II trial of weekly bicalutamide in men with elevated prostate-specific_antigen and negative prostate biopsies .
20423156	0	bicarbonate	23,34	ABTS-1	47,53	bicarbonate	ABTS-1	CHEBI:17544	172613(Tax:6239)	Chemical	Gene	START_ENTITY|ccomp|involved involved|nsubjpass|END_ENTITY	Caenorhabditis_elegans bicarbonate transporter ABTS-1 is involved in arsenite toxicity and cholinergic signaling .
2544631	0	bicarbonate	41,52	Angiotensin_II	0,14	bicarbonate	Angiotensin II	CHEBI:17544	24179(Tax:10116)	Chemical	Gene	absorption|compound|START_ENTITY stimulates|dobj|absorption stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates early proximal bicarbonate absorption in the rat by decreasing cyclic_adenosine_monophosphate .
20407206	0	bicarbonate	22,33	Bestrophin-2	0,12	bicarbonate	Bestrophin-2	CHEBI:17544	212989(Tax:10090)	Chemical	Gene	transport|amod|START_ENTITY mediates|dobj|transport mediates|nsubj|END_ENTITY	Bestrophin-2 mediates bicarbonate transport by goblet cells in mouse colon .
16414184	0	bicarbonate	33,44	CFTR	17,21	bicarbonate	CFTR	CHEBI:17544	1080	Chemical	Gene	secretion|compound|START_ENTITY role|nmod|secretion role|nmod|END_ENTITY	Critical role of CFTR in uterine bicarbonate secretion and the fertilizing capacity of sperm .
23499805	0	bicarbonate	51,62	Cholecystokinin	0,15	bicarbonate	Cholecystokinin	CHEBI:17544	25298(Tax:10116)	Chemical	Gene	secretion|compound|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Cholecystokinin but not ghrelin stimulates mucosal bicarbonate secretion in rat duodenum : Independence of feeding status and cholinergic stimuli .
12372813	0	bicarbonate	57,68	DRA	53,56	bicarbonate	DRA	CHEBI:17544	1811	Chemical	Gene	START_ENTITY|nsubj|relationship relationship|nmod|END_ENTITY	The functional and physical relationship between the DRA bicarbonate transporter and carbonic_anhydrase_II .
19181845	0	bicarbonate	64,75	Guanylyl_cyclase-D	0,18	bicarbonate	Guanylyl cyclase-D	CHEBI:17544	14918(Tax:10090)	Chemical	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	Guanylyl_cyclase-D in the olfactory CO2 neurons is activated by bicarbonate .
9403800	0	bicarbonate	46,57	PACAP	22,27	bicarbonate	PACAP	CHEBI:17544	24166(Tax:10116)	Chemical	Gene	secretion|compound|START_ENTITY effect|nmod|secretion effect|nmod|END_ENTITY	Stimulatory effect of PACAP on gastroduodenal bicarbonate secretion in rats .
3121345	0	bicarbonate	62,73	Parathyroid_hormone	0,19	bicarbonate	Parathyroid hormone	CHEBI:17544	24694(Tax:10116)	Chemical	Gene	reabsorption|nmod|START_ENTITY inhibits|dobj|reabsorption inhibits|nsubj|END_ENTITY	Parathyroid_hormone directly inhibits tubular reabsorption of bicarbonate in normocalcaemic rats with chronic_hyperparathyroidism .
22855618	0	bicarbonate	28,39	Prolactin	0,9	bicarbonate	Prolactin	CHEBI:17544	5617	Chemical	Gene	secretion|compound|START_ENTITY regulates|dobj|secretion regulates|nsubj|END_ENTITY	Prolactin regulates luminal bicarbonate secretion in the intestine of the sea bream -LRB- Sparus aurata L. -RRB- .
22116370	0	bicarbonate	10,21	SLC26A4	81,88	bicarbonate	SLC26A4	CHEBI:17544	23985(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Impact of bicarbonate , ammonium_chloride , and acetazolamide on hepatic and renal SLC26A4 expression .
10880878	1	bicarbonate	110,121	Secretin	90,98	bicarbonate	secretin	CHEBI:17544	6343	Chemical	Gene	stimulates|ccomp|START_ENTITY stimulates|nsubj|END_ENTITY	Secretin stimulates bicarbonate secretion from pancreatic duct cells , but what influence secretin exerts on intestinal tissues remains to be clarified .
6548570	0	bicarbonate	74,85	Secretin	0,8	bicarbonate	Secretin	CHEBI:17544	24769(Tax:10116)	Chemical	Gene	secretion|compound|START_ENTITY stimulate|dobj|secretion stimulate|nsubj|END_ENTITY	Secretin , VIP , and PHI stimulate rat proximal duodenal surface epithelial bicarbonate secretion in vivo .
24376658	0	bicarbonate	41,52	atrial_natriuretic_peptide	11,37	bicarbonate	atrial natriuretic peptide	CHEBI:17544	24602(Tax:10116)	Chemical	Gene	transport|amod|START_ENTITY Effects|nmod|transport Effects|nmod|END_ENTITY	Effects of atrial_natriuretic_peptide on bicarbonate transport in long - and short-looped medullary thick ascending limbs of rats .
1886888	0	bicarbonate	38,49	cholecystokinin	8,23	bicarbonate	cholecystokinin	CHEBI:17544	609547(Tax:9615)	Chemical	Gene	secretion|compound|START_ENTITY Role|nmod|secretion Role|nmod|END_ENTITY	Role of cholecystokinin in pancreatic bicarbonate secretion in dogs .
12127808	0	bicarbonate	68,79	epidermal_growth_factor	13,36	bicarbonate	epidermal growth factor	CHEBI:17544	521832(Tax:9913)	Chemical	Gene	START_ENTITY|nsubj|Influence Influence|nmod|END_ENTITY	Influence of epidermal_growth_factor on bovine pancreatic duct cell bicarbonate .
22480598	0	bicarbonate	78,89	fibroblast_growth_factor_23	40,67	bicarbonate	fibroblast growth factor 23	CHEBI:17544	8074	Chemical	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	Plant protein intake is associated with fibroblast_growth_factor_23 and serum bicarbonate levels in patients with chronic_kidney_disease : the Chronic_Renal_Insufficiency Cohort study .
12881226	0	bicarbonate	67,78	guanylate_cyclase_C	11,30	bicarbonate	guanylate cyclase C	CHEBI:17544	14917(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	A role for guanylate_cyclase_C in acid-stimulated duodenal mucosal bicarbonate secretion .
434213	0	bicarbonate	33,44	parathyroid_hormone	10,29	bicarbonate	parathyroid hormone	CHEBI:17544	100351309(Tax:9986)	Chemical	Gene	absorption|amod|START_ENTITY Effect|nmod|absorption Effect|nmod|END_ENTITY	Effect of parathyroid_hormone on bicarbonate absorption by proximal tubules in vitro .
6972849	0	bicarbonate	33,44	parathyroid_hormone	10,29	bicarbonate	parathyroid hormone	CHEBI:17544	100713626	Chemical	Gene	secretion|amod|START_ENTITY END_ENTITY|nmod|secretion	Effect of parathyroid_hormone on bicarbonate secretion in the guinea-pig stomach and the amphibian isolated gastric mucosa .
940283	0	bicarbonate	49,60	parathyroid_hormone	17,36	bicarbonate	parathyroid hormone	CHEBI:17544	403986(Tax:9615)	Chemical	Gene	transport|compound|START_ENTITY effects|nmod|transport effects|nmod|END_ENTITY	Acute effects of parathyroid_hormone on proximal bicarbonate transport in the dog .
956369	0	bicarbonate	68,79	parathyroid_hormone	39,58	bicarbonate	parathyroid hormone	CHEBI:17544	24694(Tax:10116)	Chemical	Gene	reabsorption|compound|START_ENTITY study|nmod|reabsorption study|nmod|effect effect|nmod|END_ENTITY	A micropuncture study of the effect of parathyroid_hormone on renal bicarbonate reabsorption .
8875602	0	bicarbonate	45,56	protein_kinase_C	8,24	bicarbonate	protein kinase C	CHEBI:17544	100302324(Tax:10141)	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of protein_kinase_C in duodenal mucosal bicarbonate secretion in the guinea_pig .
2682521	0	bicarbonate	13,24	renin	47,52	bicarbonate	renin	CHEBI:17544	24715(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|sensitivity sensitivity|nmod|END_ENTITY	Influence of bicarbonate on the sensitivity of renin release to sodium_chloride .
1797	0	bicarbonate	26,37	secretin	63,71	bicarbonate	secretin	CHEBI:17544	483407(Tax:9615)	Chemical	Gene	secretion|nsubj|START_ENTITY secretion|nmod|END_ENTITY	Cyclic-AMP and pancreatic bicarbonate secretion in response to secretin in dogs .
18021	0	bicarbonate	127,138	secretin	43,51	bicarbonate	secretin	CHEBI:17544	483407(Tax:9615)	Chemical	Gene	response|compound|START_ENTITY secretin|nmod|response role|nmod|secretin pH.|dobj|role meals|acl|pH. responses|nmod|meals responses|compound|END_ENTITY	Pancreatic bicarbonate , serum gastrin , and secretin responses to meals varying in pH. The role of secretin in the postprandial bicarbonate response by the pancreas is not clear .
18787	0	bicarbonate	46,57	secretin	14,22	bicarbonate	secretin	CHEBI:17544	6343	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|release release|compound|END_ENTITY	Inhibition of secretin release and pancreatic bicarbonate secretion by somatostatin infusion in man .
1947769	0	bicarbonate	42,53	secretin	83,91	bicarbonate	secretin	CHEBI:17544	397464(Tax:9823)	Chemical	Gene	secretion|compound|START_ENTITY secretion|nmod|infusion infusion|nmod|END_ENTITY	Pancreatic , hepatic , and duodenal mucosal bicarbonate secretion during infusion of secretin and cholecystokinin .
34207	0	bicarbonate	57,68	secretin	30,38	bicarbonate	secretin	CHEBI:17544	6343	Chemical	Gene	secretion|compound|START_ENTITY significance|nmod|secretion significance|nmod|END_ENTITY	Physiological significance of secretin in the pancreatic bicarbonate secretion .
424692	0	bicarbonate	57,68	secretin	30,38	bicarbonate	secretin	CHEBI:17544	6343	Chemical	Gene	secretion|compound|START_ENTITY significance|nmod|secretion significance|nmod|END_ENTITY	Physiological significance of secretin in the pancreatic bicarbonate secretion .
424692	2	bicarbonate	95,106	secretin	154,162	bicarbonate	secretin	CHEBI:17544	6343	Chemical	Gene	START_ENTITY|nmod|increase increase|nmod|concentration concentration|compound|END_ENTITY	Pancreatic bicarbonate response to a physiological increase in plasma secretin concentration .
549430	0	bicarbonate	61,72	secretin	19,27	bicarbonate	secretin	CHEBI:17544	6343	Chemical	Gene	secretion|amod|START_ENTITY END_ENTITY|nmod|secretion	Effect of low dose secretin and caerulein on pure pancreatic bicarbonate secretion and plasma secretin in man .
6065757	0	bicarbonate	22,33	secretin	10,18	bicarbonate	secretin	CHEBI:17544	24769(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY END_ENTITY|nmod|secretion	Effect of secretin on bicarbonate secretion in fluid perfusing the rat ileum .
6268503	0	bicarbonate	67,78	secretin	140,148	bicarbonate	secretin	CHEBI:17544	6343	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of graded doses of PGE2 on pancreatic exocrine secretion of bicarbonate , chymotrypsin and cyclic_nucleotides during i.v. infusion of secretin in man .
6303892	0	bicarbonate	65,76	secretin	123,131	bicarbonate	secretin	CHEBI:17544	6343	Chemical	Gene	secretion|compound|START_ENTITY cholecystokinin-octapeptide|nmod|secretion effect|nmod|cholecystokinin-octapeptide stimulated|nsubj|effect stimulated|nmod|dose dose|nmod|END_ENTITY	Potentiation effect of cholecystokinin-octapeptide on pancreatic bicarbonate secretion stimulated by a physiologic dose of secretin in humans .
648803	4	bicarbonate	734,745	secretin	619,627	bicarbonate	secretin	CHEBI:17544	6343	Chemical	Gene	release|nmod|START_ENTITY inhibition|nmod|release diminished|nsubjpass|inhibition diminished|ccomp|impaired impaired|nsubj|END_ENTITY	In chronic pancreatitis , secretin releasing response to acidification was markedly impaired , in addition , inhibition of secretin release by bicarbonate was diminished due to a lack of bicarbonate flow from the pancreas .
648803	4	bicarbonate	778,789	secretin	619,627	bicarbonate	secretin	CHEBI:17544	6343	Chemical	Gene	flow|amod|START_ENTITY lack|nmod|flow due|nmod|lack diminished|xcomp|due diminished|ccomp|impaired impaired|nsubj|END_ENTITY	In chronic pancreatitis , secretin releasing response to acidification was markedly impaired , in addition , inhibition of secretin release by bicarbonate was diminished due to a lack of bicarbonate flow from the pancreas .
6669945	0	bicarbonate	33,44	secretin	96,104	bicarbonate	secretin	CHEBI:17544	483407(Tax:9615)	Chemical	Gene	output|amod|START_ENTITY Effect|nmod|output Effect|nmod|END_ENTITY	Effect of atropine on pancreatic bicarbonate output and plasma concentrations of immunoreactive secretin in response to intraduodenal stimulants .
4502428	0	bicuculline	10,21	GABA_receptor	29,42	bicuculline	GABA receptor	MESH:D001640	11337	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of bicuculline on the GABA_receptor of the crayfish neuromuscular junction .
17599916	0	bicyclam	51,59	CXCR4	91,96	bicyclam	CXCR4	MESH:C088327	7852	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|nmod|receptor receptor|compound|END_ENTITY	Molecular mechanism of action of monocyclam versus bicyclam non-peptide antagonists in the CXCR4 chemokine receptor .
22989333	0	bicyclic_iminopyrimidinones	25,52	beta_amyloid_cleaving_enzyme-1	56,86	bicyclic iminopyrimidinones	beta amyloid cleaving enzyme-1	null	29392(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Design and validation of bicyclic_iminopyrimidinones as beta_amyloid_cleaving_enzyme-1 -LRB- BACE1 -RRB- inhibitors : conformational constraint to favor a bioactive conformation .
15740071	0	bicyclic_monoterpenoids	47,70	acetylcholinesterase	14,34	bicyclic monoterpenoids	acetylcholinesterase	null	43	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activity activity|amod|END_ENTITY	Inhibition of acetylcholinesterase activity by bicyclic_monoterpenoids .
21672429	0	bicyclol	12,20	PAI-1	30,35	bicyclol	PAI-1	MESH:C477843	24617(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	-LSB- Effects of bicyclol on renal PAI-1 expression in rats with uniliteral ureteral_obstruction -RSB- .
23850770	0	bicyclol	26,34	TLR4	74,78	bicyclol	TLR4	MESH:C477843	29260(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|END_ENTITY	Neuroprotective effect of bicyclol in rat ischemic_stroke : down-regulates TLR4 , TLR9 , TRAF6 , NF-kB , MMP-9 and up-regulates claudin-5 expression .
8846747	0	bifemelane_hydrochloride	11,35	neuropeptide_Y	46,60	bifemelane hydrochloride	neuropeptide Y	MESH:C031906	4852	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|concentrations concentrations|amod|END_ENTITY	Effects of bifemelane_hydrochloride on plasma neuropeptide_Y , 3-methoxy-4-hydroxyphenylethylene_glycol and 5-hydroxy-indole_acetic_acid concentrations in patients with cerebral_infarction .
23220523	0	bifendate	56,65	catalase	42,50	bifendate	catalase	MESH:C465548	847	Chemical	Gene	study|nmod|START_ENTITY study|nmod|interaction interaction|nmod|END_ENTITY	Spectroscopic study on the interaction of catalase with bifendate and analogs .
25759531	0	bifidobacterium	10,25	defensin-5	29,39	bifidobacterium	defensin-5	null	290856(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of bifidobacterium on defensin-5 expression in intestinal_injury of preweaning rats .
16828525	0	biflavones	8,18	cathepsin_B	42,53	biflavones	cathepsin B	null	1508	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Natural biflavones as novel inhibitors of cathepsin_B and K. Cathepsin_B and K , two important members in lysosomal proteases , involve in many serious human diseases , such as tumor and osteoporosis .
16527246	0	biflavonoid	24,35	iNOS	72,76	biflavonoid	iNOS	CHEBI:50128	18126(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	The naturally occurring biflavonoid , ochnaflavone , inhibits LPS-induced iNOS expression , which is mediated by ERK1/2 via NF-kappaB regulation , in RAW264 .7 cells .
16504502	0	biflavonoids	41,53	phospholipase_A2	13,29	biflavonoids	phospholipase A2	MESH:D044946	151056	Chemical	Gene	START_ENTITY|nsubj|Synthesis Synthesis|nmod|inhibitory inhibitory|amod|END_ENTITY	Synthesis of phospholipase_A2 inhibitory biflavonoids .
23582785	0	biguanides	13,23	OCT2	60,64	biguanides	OCT2	MESH:D001645	6582	Chemical	Gene	Transport|nmod|START_ENTITY Transport|nmod|END_ENTITY	Transport of biguanides by human organic cation transporter OCT2 .
1234581	1	biguanides	158,168	insulin	122,129	biguanides	insulin	MESH:D001645	3630	Chemical	Gene	Assessment|nmod|START_ENTITY Assessment|nmod|END_ENTITY	Assessment of control under treatment with constant and variable doses of insulin with or without addition of biguanides .
4995366	0	biguanides	56,66	insulin	94,101	biguanides	insulin	MESH:D001645	3630	Chemical	Gene	action|nmod|START_ENTITY demonstration|nmod|action demonstration|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Experimental demonstration of the simulating action of biguanides -LRB- phenformin , metformin -RRB- on insulin secretion -RSB- .
6996339	0	biguanides	15,25	insulin	29,36	biguanides	insulin	MESH:D001645	3630	Chemical	Gene	START_ENTITY|nmod|sensitivity sensitivity|compound|END_ENTITY	-LSB- The effect of biguanides on insulin sensitivity of maturity onset diabetics -LRB- author 's transl -RRB- -RSB- .
7033271	0	biguanides	37,47	insulin	69,76	biguanides	insulin	MESH:D001645	3630	Chemical	Gene	effect|nmod|START_ENTITY Comparison|nmod|effect Comparison|nmod|binding binding|compound|END_ENTITY	Comparison of the in vitro effect of biguanides and sulfonylureas on insulin binding of its receptors in target cells .
16274260	0	bilastine	28,37	histamine_H1_receptor	55,76	bilastine	histamine H1 receptor	MESH:C445659	100135539(Tax:10141)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Preclinical pharmacology of bilastine , a new selective histamine_H1_receptor antagonist : receptor selectivity and in vitro antihistaminic activity .
26045262	0	bile_Acid	65,74	Diet1	0,5	bile Acid	Diet1	CHEBI:3098	112396(Tax:10090)	Chemical	Gene	synthesis|amod|START_ENTITY regulator|nmod|synthesis regulator|nsubj|END_ENTITY	Diet1 is a regulator of fibroblast_growth_factor_15 / 19-dependent bile_Acid synthesis .
26045262	0	bile_Acid	65,74	fibroblast_growth_factor_15	24,51	bile Acid	fibroblast growth factor 15	CHEBI:3098	14170(Tax:10090)	Chemical	Gene	synthesis|amod|START_ENTITY synthesis|amod|END_ENTITY	Diet1 is a regulator of fibroblast_growth_factor_15 / 19-dependent bile_Acid synthesis .
16955758	0	bile_acid	21,30	3_alpha-hydroxysteroid_dehydrogenase	54,90	bile acid	3 alpha-hydroxysteroid dehydrogenase	CHEBI:3098	8644	Chemical	Gene	START_ENTITY|nmod|serum serum|nmod|END_ENTITY	Discrete analysis of bile_acid in serum and bile with 3_alpha-hydroxysteroid_dehydrogenase and diaphorase immobilized onto alkylamine glass beads .
2317526	0	bile_acid	27,36	3_alpha-hydroxysteroid_dehydrogenase	63,99	bile acid	3 alpha-hydroxysteroid dehydrogenase	CHEBI:3098	291283(Tax:10116)	Chemical	Gene	Oxidation|nmod|START_ENTITY precursors|nsubj|Oxidation precursors|nmod|hepatic hepatic|amod|END_ENTITY	Oxidation and reduction of bile_acid precursors by rat hepatic 3_alpha-hydroxysteroid_dehydrogenase and inhibition by bile_acids and indomethacin .
3468121	0	bile_acid	56,65	3_alpha-hydroxysteroid_dehydrogenase	0,36	bile acid	3 alpha-hydroxysteroid dehydrogenase	CHEBI:3098	291283(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	3_alpha-hydroxysteroid_dehydrogenase activity of the Y ' bile_acid binders in rat liver cytosol .
7515872	0	bile_acid	99,108	3_alpha-hydroxysteroid_dehydrogenase	12,48	bile acid	3 alpha-hydroxysteroid dehydrogenase	CHEBI:3098	291283(Tax:10116)	Chemical	Gene	pathway|amod|START_ENTITY function|nmod|pathway expression|nmod|function Rat|dep|expression Rat|amod|END_ENTITY	Rat hepatic 3_alpha-hydroxysteroid_dehydrogenase : expression of cDNA and physiological function in bile_acid biosynthetic pathway .
16749855	0	bile_acid	24,33	ASBT	47,51	bile acid	ASBT	CHEBI:3098	6555	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Apical sodium dependent bile_acid transporter -LRB- ASBT , SLC10A2 -RRB- : a potential prodrug target .
18063707	0	bile_acid	20,29	ASBT	43,47	bile acid	ASBT	CHEBI:3098	6555	Chemical	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Modulation of ileal bile_acid transporter -LRB- ASBT -RRB- activity by depletion of plasma membrane cholesterol : association with lipid rafts .
21341987	0	bile_acid	111,120	ASBT	134,138	bile acid	ASBT	CHEBI:3098	6555	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Genetic polymorphisms in Na + - taurocholate_co-transporting_polypeptide -LRB- NTCP -RRB- and ileal apical sodium-dependent bile_acid transporter -LRB- ASBT -RRB- and ethnic comparisons of functional variants of NTCP among Asian populations .
21591702	0	bile_acid	22,31	ASBT	78,82	bile acid	ASBT	CHEBI:3098	20494(Tax:10090)	Chemical	Gene	excretion|amod|START_ENTITY induces|dobj|excretion induces|nmod|expression expression|nmod|END_ENTITY	Barley intake induces bile_acid excretion by reduced expression of intestinal ASBT and NPC1L1 in C57BL/6J mice .
21649730	0	bile_acid	79,88	ASBT	102,106	bile acid	ASBT	CHEBI:3098	6555	Chemical	Gene	START_ENTITY|dobj|transporter transporter|appos|END_ENTITY	Functional characterization of genetic variants in the apical sodium-dependent bile_acid transporter -LRB- ASBT ; SLC10A2 -RRB- .
21976025	0	bile_acid	50,59	ASBT	77,81	bile acid	ASBT	CHEBI:3098	6555	Chemical	Gene	symporter|amod|START_ENTITY homologue|nmod|symporter structure|nmod|homologue END_ENTITY|nsubj|structure	Crystal structure of a bacterial homologue of the bile_acid sodium symporter ASBT .
22016432	0	bile_acid	47,56	ASBT	69,73	bile acid	ASBT	CHEBI:3098	6555	Chemical	Gene	transporter|amod|START_ENTITY encoding|dobj|transporter gene|acl|encoding Regulation|nmod|gene END_ENTITY|nsubj|Regulation	Regulation of the gene encoding the intestinal bile_acid transporter ASBT by the caudal-type homeobox proteins CDX1 and CDX2 .
19386592	0	bile_acid	67,76	Apobec-1	91,99	bile acid	Apobec-1	CHEBI:3098	11810(Tax:10090)	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|nmod|END_ENTITY	Decreased expression of cholesterol_7alpha-hydroxylase and altered bile_acid metabolism in Apobec-1 - / - mice lead to increased gallstone susceptibility .
9755247	0	bile_acid	30,39	CD-1	73,77	bile acid	CD-1	CHEBI:3098	111334(Tax:10090)	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|nmod|mice mice|compound|END_ENTITY	Gender-related differences in bile_acid and sterol metabolism in outbred CD-1 mice fed low - and high-cholesterol diets .
15454728	0	bile_acid	28,37	CYP3A4	14,20	bile acid	CYP3A4	CHEBI:3098	1576	Chemical	Gene	FXR|amod|START_ENTITY END_ENTITY|nmod|FXR	Regulation of CYP3A4 by the bile_acid receptor FXR : evidence for functional binding sites in the CYP3A4 gene .
15454728	0	bile_acid	28,37	CYP3A4	97,103	bile acid	CYP3A4	CHEBI:3098	1576	Chemical	Gene	FXR|amod|START_ENTITY CYP3A4|nmod|FXR Regulation|nmod|CYP3A4 Regulation|dep|evidence evidence|nmod|sites sites|nmod|gene gene|compound|END_ENTITY	Regulation of CYP3A4 by the bile_acid receptor FXR : evidence for functional binding sites in the CYP3A4 gene .
15708356	0	bile_acid	18,27	CYP3A4	49,55	bile acid	CYP3A4	CHEBI:3098	1576	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|nmod|END_ENTITY	Novel pathways of bile_acid metabolism involving CYP3A4 .
25533663	0	bile_acid	52,61	CYP7A1	93,99	bile acid	CYP7A1	CHEBI:3098	13122(Tax:10090)	Chemical	Gene	homeostasis|amod|START_ENTITY homeostasis|nmod|END_ENTITY	Thyroid-stimulating hormone -LRB- TSH -RRB- regulates hepatic bile_acid homeostasis via SREBP-2 / HNF-4a / CYP7A1 axis .
9070187	0	bile_acid	26,35	Cholecystokinin	0,15	bile acid	Cholecystokinin	CHEBI:3098	397468(Tax:9823)	Chemical	Gene	START_ENTITY|nsubj|increases increases|compound|END_ENTITY	Cholecystokinin increases bile_acid synthesis with total parenteral nutrition but does not prevent stone formation .
11030332	0	bile_acid	78,87	FXR	46,49	bile acid	FXR	CHEBI:3098	9971	Chemical	Gene	START_ENTITY|nsubj|cascade cascade|nmod|SHP-1 SHP-1|compound|END_ENTITY	A regulatory cascade of the nuclear receptors FXR , SHP-1 , and LRH-1 represses bile_acid biosynthesis .
11150726	0	bile_acid	7,16	FXR	0,3	bile acid	FXR	CHEBI:3098	9971	Chemical	Gene	receptor|amod|START_ENTITY END_ENTITY|appos|receptor	FXR , a bile_acid receptor and biological sensor .
12496277	0	bile_acid	51,60	FXR	70,73	bile acid	FXR	CHEBI:3098	9971	Chemical	Gene	receptor|amod|START_ENTITY modulators|nmod|receptor Identification|nmod|modulators END_ENTITY|nsubj|Identification	Identification of gene-selective modulators of the bile_acid receptor FXR .
12525500	4	bile_acid	666,675	FXR	583,586	bile acid	FXR	CHEBI:3098	9971	Chemical	Gene	transporter|amod|START_ENTITY pump|appos|transporter transcription|nmod|pump transcription|compound|END_ENTITY	Here we show that GS , although an FXR antagonist in coactivator association assays , enhances FXR agonist-induced transcription of bile_salt export pump -LRB- BSEP -RRB- , a major hepatic bile_acid transporter .
12718893	0	bile_acid	21,30	FXR	78,81	bile acid	FXR	CHEBI:3098	9971	Chemical	Gene	basis|nmod|START_ENTITY END_ENTITY|nsubj|basis	Structural basis for bile_acid binding and activation of the nuclear receptor FXR .
12749886	0	bile_acid	33,42	FXR	80,83	bile acid	FXR	CHEBI:3098	9971	Chemical	Gene	START_ENTITY|dobj|agonist agonist|nmod|farnesoid_X_receptor farnesoid_X_receptor|appos|END_ENTITY	Binding mode of 6ECDCA , a potent bile_acid agonist of the farnesoid_X_receptor -LRB- FXR -RRB- .
12971955	0	bile_acid	16,25	FXR	36,39	bile acid	FXR	CHEBI:3098	20186(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Role of nuclear bile_acid receptor , FXR , in adaptive ABC transporter regulation by cholic and ursodeoxycholic_acid in mouse liver , kidney and intestine .
14992012	0	bile_acid	8,17	FXR	27,30	bile acid	FXR	CHEBI:3098	9971	Chemical	Gene	receptor|amod|START_ENTITY -RSB-|nmod|receptor -RSB-|nsubj|END_ENTITY	-LSB- On the bile_acid receptor FXR -RSB- .
15329387	0	bile_acid	43,52	FXR	62,65	bile acid	FXR	CHEBI:3098	9971	Chemical	Gene	receptor|amod|START_ENTITY coactivation|nmod|receptor END_ENTITY|nsubj|coactivation	Ligand-dependent coactivation of the human bile_acid receptor FXR by the peroxisome_proliferator-activated_receptor_gamma_coactivator-1alpha .
15590640	0	bile_acid	46,55	FXR	65,68	bile acid	FXR	CHEBI:3098	60351(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY expression|nmod|receptor Regulation|nmod|expression END_ENTITY|nsubj|Regulation	Regulation of complement C3 expression by the bile_acid receptor FXR .
15604525	0	bile_acid	85,94	FXR	35,38	bile acid	FXR	CHEBI:3098	9971	Chemical	Gene	signaling|amod|START_ENTITY role|nmod|signaling expression|dep|role induces|dobj|expression induces|nsubj|Activation Activation|nmod|END_ENTITY	Activation of the nuclear receptor FXR induces fibrinogen expression : a new role for bile_acid signaling .
16101408	0	bile_acid	30,39	FXR	0,3	bile acid	FXR	CHEBI:3098	9971	Chemical	Gene	target|nmod|START_ENTITY END_ENTITY|appos|target	FXR , a therapeutic target for bile_acid and lipid_disorders .
16178789	0	bile_acid	26,35	FXR	8,11	bile acid	FXR	CHEBI:3098	9971	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of FXR in regulating bile_acid homeostasis and relevance for human diseases .
17054793	0	bile_acid	18,27	FXR	37,40	bile acid	FXR	CHEBI:3098	9971	Chemical	Gene	receptor|amod|START_ENTITY Expression|nmod|receptor END_ENTITY|nsubj|Expression	Expression of the bile_acid receptor FXR in Barrett 's _ esophagus and enhancement of apoptosis by guggulsterone in vitro .
17823457	0	bile_acid	36,45	FXR	0,3	bile acid	FXR	CHEBI:3098	20186(Tax:10090)	Chemical	Gene	excretion|amod|START_ENTITY reduce|dobj|excretion reduce|nsubj|agonists agonists|compound|END_ENTITY	FXR agonists and FGF15 reduce fecal bile_acid excretion in a mouse model of bile_acid_malabsorption .
18927204	0	bile_acid	32,41	FXR	12,15	bile acid	FXR	CHEBI:3098	9971	Chemical	Gene	homeostasis|amod|START_ENTITY disorders|nmod|homeostasis role|nmod|disorders role|nmod|END_ENTITY	The role of FXR in disorders of bile_acid homeostasis .
18988759	0	bile_acid	163,172	FXR	105,108	bile acid	FXR	CHEBI:3098	20186(Tax:10090)	Chemical	Gene	absorption|amod|START_ENTITY suppression|nmod|absorption accumulation|dep|suppression accumulation|nmod|bile_acids bile_acids|nmod|farnesoid_X_receptor farnesoid_X_receptor|appos|END_ENTITY	Cholesterol feeding prevents hepatic accumulation of bile_acids in cholic_acid-fed farnesoid_X_receptor -LRB- FXR -RRB- - null mice : FXR-independent suppression of intestinal bile_acid absorption .
19047134	0	bile_acid	8,17	FXR	27,30	bile acid	FXR	CHEBI:3098	20186(Tax:10090)	Chemical	Gene	START_ENTITY|ccomp|protects protects|nsubj|END_ENTITY	Nuclear bile_acid receptor FXR protects against intestinal_tumorigenesis .
19228886	0	bile_acid	71,80	FXR	122,125	bile acid	FXR	CHEBI:3098	9971	Chemical	Gene	FXR|amod|START_ENTITY downregulation|nmod|FXR leads|nmod|downregulation leads|dobj|effect effect|nmod|GW4064 GW4064|compound|END_ENTITY	Knockdown of ATP8B1 expression leads to specific downregulation of the bile_acid sensor FXR in HepG2 cells : effect of the FXR agonist GW4064 .
19273385	0	bile_acid	21,30	FXR	65,68	bile acid	FXR	CHEBI:3098	9971	Chemical	Gene	metabolism|amod|START_ENTITY regulation|nmod|metabolism regulation|nmod|trio trio|compound|END_ENTITY	Master regulation of bile_acid and xenobiotic metabolism via the FXR , PXR and CAR trio .
19393742	2	bile_acid	302,311	FXR	292,295	bile acid	FXR	CHEBI:3098	20186(Tax:10090)	Chemical	Gene	sensor|amod|START_ENTITY sensor|nsubj|farnesoid_X_receptor farnesoid_X_receptor|appos|END_ENTITY	The farnesoid_X_receptor -LRB- FXR -RRB- is a bile_acid sensor expressed in immune cells such as macrophages where it exerts counter-regulatory effects .
20155456	0	bile_acid	13,22	FXR	106,109	bile acid	FXR	CHEBI:3098	60351(Tax:10116)	Chemical	Gene	pool|amod|START_ENTITY Reduction|nmod|pool causes|nsubj|Reduction causes|dobj|liver_regeneration liver_regeneration|acl|accompanied accompanied|nmod|expression expression|nmod|END_ENTITY	Reduction in bile_acid pool causes delayed liver_regeneration accompanied by down-regulated expression of FXR and c-Jun mRNA in rats .
21383957	0	bile_acid	24,33	FXR	43,46	bile acid	FXR	CHEBI:3098	60351(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY Deciphering|dobj|receptor END_ENTITY|csubj|Deciphering	Deciphering the nuclear bile_acid receptor FXR paradigm .
21439373	0	bile_acid	40,49	FXR	59,62	bile acid	FXR	CHEBI:3098	20186(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY discovery|nmod|receptor Proteomics|nmod|discovery END_ENTITY|nsubj|Proteomics	Proteomics for the discovery of nuclear bile_acid receptor FXR targets .
21632533	0	bile_acid	9,18	FXR	68,71	bile acid	FXR	CHEBI:3098	20186(Tax:10090)	Chemical	Gene	size|amod|START_ENTITY Lowering|dobj|size Lowering|nmod|farnesoid_X_receptor farnesoid_X_receptor|appos|END_ENTITY	Lowering bile_acid pool size with a synthetic farnesoid_X_receptor -LRB- FXR -RRB- agonist induces obesity and diabetes through reduced energy expenditure .
22929053	0	bile_acid	73,82	FXR	92,95	bile acid	FXR	CHEBI:3098	9971	Chemical	Gene	receptor|amod|START_ENTITY encoding|dobj|receptor encoding|advmod|END_ENTITY	Association of genetic variation in the NR1H4 gene , encoding the nuclear bile_acid receptor FXR , with inflammatory_bowel_disease .
23395169	0	bile_acid	25,34	FXR	122,125	bile acid	FXR	CHEBI:3098	20186(Tax:10090)	Chemical	Gene	metabolism|amod|START_ENTITY regulates|dobj|metabolism regulates|advcl|reducing reducing|dobj|levels levels|nmod|tauro-beta-muricholic_acid tauro-beta-muricholic_acid|appos|antagonist antagonist|compound|END_ENTITY	Gut microbiota regulates bile_acid metabolism by reducing the levels of tauro-beta-muricholic_acid , a naturally occurring FXR antagonist .
24037988	0	bile_acid	62,71	FXR	103,106	bile acid	FXR	CHEBI:3098	9971	Chemical	Gene	farnesoid_X_receptor|amod|START_ENTITY farnesoid_X_receptor|appos|END_ENTITY	Glucose sensing O-GlcNAcylation pathway regulates the nuclear bile_acid receptor farnesoid_X_receptor -LRB- FXR -RRB- .
24999016	0	bile_acid	42,51	FXR	8,11	bile acid	FXR	CHEBI:3098	9971	Chemical	Gene	dysmetabolism|amod|START_ENTITY associated|nmod|dysmetabolism associated|nsubjpass|END_ENTITY	Altered FXR signalling is associated with bile_acid dysmetabolism in short_bowel_syndrome-associated liver_disease .
26019035	0	bile_acid	52,61	FXR	21,24	bile acid	FXR	CHEBI:3098	9971	Chemical	Gene	expression|amod|START_ENTITY up-regulates|dobj|expression up-regulates|nsubj|END_ENTITY	The nuclear receptor FXR , but not LXR , up-regulates bile_acid transporter expression in non-alcoholic_fatty_liver_disease .
23981126	0	bile_acid	45,54	Fibroblast_growth_factor_19	0,27	bile acid	Fibroblast growth factor 19	CHEBI:3098	9965	Chemical	Gene	diarrhoea|amod|START_ENTITY patients|nmod|diarrhoea END_ENTITY|nmod|patients	Fibroblast_growth_factor_19 in patients with bile_acid diarrhoea : a prospective comparison of FGF19 serum assay and SeHCAT retention .
23488746	0	bile_acid	9,18	GPBAR1	70,76	bile acid	GPBAR1	CHEBI:3098	227289(Tax:10090)	Chemical	Gene	Systemic|acl|START_ENTITY Systemic|appos|END_ENTITY	Systemic bile_acid sensing by G_protein-coupled_bile_acid_receptor_1 -LRB- GPBAR1 -RRB- promotes PYY and GLP-1 release .
26567894	0	bile_acid	88,97	GPBAR1	65,71	bile acid	GPBAR1	CHEBI:3098	151306	Chemical	Gene	scaffold|amod|START_ENTITY exploiting|dobj|scaffold targeting|parataxis|exploiting targeting|dobj|END_ENTITY	Structure-based drug design targeting the cell membrane receptor GPBAR1 : exploiting the bile_acid scaffold towards selective agonism .
23488746	0	bile_acid	9,18	G_protein-coupled_bile_acid_receptor_1	30,68	bile acid	G protein-coupled bile acid receptor 1	CHEBI:3098	227289(Tax:10090)	Chemical	Gene	START_ENTITY|xcomp|sensing sensing|nmod|END_ENTITY	Systemic bile_acid sensing by G_protein-coupled_bile_acid_receptor_1 -LRB- GPBAR1 -RRB- promotes PYY and GLP-1 release .
20553563	0	bile_acid	46,55	GpBAR1	25,31	bile acid	GpBAR1	CHEBI:3098	227289(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|nsubj|END_ENTITY	Missing link identified : GpBAR1 is a neuronal bile_acid receptor .
21735468	0	bile_acid	22,31	Gpbar1	42,48	bile acid	Gpbar1	CHEBI:3098	227289(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	The G-protein-coupled bile_acid receptor , Gpbar1 -LRB- TGR5 -RRB- , negatively regulates hepatic inflammatory response through antagonizing nuclear factor k light-chain enhancer of activated B cells -LRB- NF-kB -RRB- in mice .
1805095	0	bile_acid	77,86	HMG-CoA_reductase	131,148	bile acid	HMG-CoA reductase	CHEBI:3098	25675(Tax:10116)	Chemical	Gene	acyltransferase|amod|START_ENTITY acyltransferase|amod|END_ENTITY	Effects of perturbations in hepatic free and esterified cholesterol pools on bile_acid synthesis , cholesterol_7_alpha-hydroxylase , HMG-CoA_reductase , acyl-CoA : cholesterol acyltransferase and cytosolic cholesteryl_ester hydrolase .
7751816	0	bile_acid	104,113	HMG-CoA_reductase	45,62	bile acid	HMG-CoA reductase	CHEBI:3098	3156	Chemical	Gene	biosynthesis|amod|START_ENTITY intermediates|nmod|biosynthesis specificity|nmod|intermediates specificity|nmod|suppression suppression|nmod|END_ENTITY	Structural specificity in the suppression of HMG-CoA_reductase in human fibroblasts by intermediates in bile_acid biosynthesis .
22673116	0	bile_acid	49,58	MRP2	73,77	bile acid	MRP2	CHEBI:3098	1244	Chemical	Gene	transporters|amod|START_ENTITY transporters|appos|END_ENTITY	Differential effect of troglitazone on the human bile_acid transporters , MRP2 and BSEP , in the PXB hepatic chimeric mouse .
21175587	0	bile_acid	44,53	Mdr1	110,114	bile acid	Mdr1	CHEBI:3098	110357(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Mitochondrial genome depletion dysregulates bile_acid - and paracetamol-induced expression of the transporters Mdr1 , Mrp1 and Mrp4 in liver cells .
24845614	0	bile_acid	16,25	NTCP	114,118	bile acid	NTCP	CHEBI:3098	6554	Chemical	Gene	transporter|amod|START_ENTITY Kinetics|nmod|transporter taurocholate|nsubj|Kinetics taurocholate|dobj|polypeptide polypeptide|appos|END_ENTITY	Kinetics of the bile_acid transporter and hepatitis_B_virus receptor Na + / taurocholate cotransporting polypeptide -LRB- NTCP -RRB- in hepatocytes .
14598021	0	bile_acid	19,28	Ntcp	41,45	bile acid	Ntcp	CHEBI:3098	6554	Chemical	Gene	START_ENTITY|ccomp|facilitates facilitates|nsubj|END_ENTITY	The hepatocellular bile_acid transporter Ntcp facilitates uptake of the lethal mushroom toxin alpha-amanitin .
17897632	0	bile_acid	22,31	Ntcp	45,49	bile acid	Ntcp	CHEBI:3098	20493(Tax:10090)	Chemical	Gene	Regulation|nmod|START_ENTITY transporters|nsubj|Regulation transporters|dobj|END_ENTITY	Regulation of hepatic bile_acid transporters Ntcp and Bsep expression .
23125159	0	bile_acid	12,21	Ntcp	35,39	bile acid	Ntcp	CHEBI:3098	6554	Chemical	Gene	START_ENTITY|ccomp|downregulated downregulated|nsubjpass|END_ENTITY	The hepatic bile_acid transporters Ntcp and Mrp2 are downregulated in experimental necrotizing_enterocolitis .
16134950	0	bile_acid	59,68	Part_1	93,99	bile acid	Part 1	CHEBI:3098	25859	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Discovery of potent , nonsystemic apical sodium-codependent bile_acid transporter inhibitors -LRB- Part_1 -RRB- .
11742882	0	bile_acid	22,31	SLC10A2	50,57	bile acid	SLC10A2	CHEBI:3098	6555	Chemical	Gene	START_ENTITY|dobj|gene gene|appos|END_ENTITY	Analysis of the ileal bile_acid transporter gene , SLC10A2 , in subjects with familial_hypertriglyceridemia .
14684580	0	bile_acid	12,21	SLC10A2	45,52	bile acid	SLC10A2	CHEBI:3098	6555	Chemical	Gene	ASBT|amod|START_ENTITY ASBT|appos|END_ENTITY	Human ileal bile_acid transporter gene ASBT -LRB- SLC10A2 -RRB- is transactivated by the glucocorticoid_receptor .
15350125	0	bile_acid	127,136	SLC10A2	150,157	bile acid	SLC10A2	CHEBI:3098	6555	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Topology scanning and putative three-dimensional structure of the extracellular binding domains of the apical sodium-dependent bile_acid transporter -LRB- SLC10A2 -RRB- .
15952798	0	bile_acid	130,139	SLC10A2	153,160	bile acid	SLC10A2	CHEBI:3098	6555	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Site-directed mutagenesis and use of bile_acid-MTS conjugates to probe the role of cysteines in the human apical sodium-dependent bile_acid transporter -LRB- SLC10A2 -RRB- .
16749855	0	bile_acid	24,33	SLC10A2	53,60	bile acid	SLC10A2	CHEBI:3098	6555	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|ASBT ASBT|dep|END_ENTITY	Apical sodium dependent bile_acid transporter -LRB- ASBT , SLC10A2 -RRB- : a potential prodrug target .
18311924	0	bile_acid	55,64	SLC10A2	84,91	bile acid	SLC10A2	CHEBI:3098	6555	Chemical	Gene	hASBT|amod|START_ENTITY hASBT|appos|END_ENTITY	Cytosolic half of transmembrane domain IV of the human bile_acid transporter hASBT -LRB- SLC10A2 -RRB- forms part of the substrate translocation pathway .
19184108	0	bile_acid	46,55	SLC10A2	69,76	bile acid	SLC10A2	CHEBI:3098	6555	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Mutation screening of apical sodium-dependent bile_acid transporter -LRB- SLC10A2 -RRB- : novel haplotype block including six newly identified variants linked to reduced expression .
19823678	0	bile_acid	67,76	SLC10A2	17,24	bile acid	SLC10A2	CHEBI:3098	6555	Chemical	Gene	transporter|amod|START_ENTITY encoding|dobj|transporter gene|acl|encoding gene|compound|END_ENTITY	A variant of the SLC10A2 gene encoding the apical sodium-dependent bile_acid transporter is a risk factor for gallstone_disease .
20884752	0	bile_acid	103,112	SLC10A2	126,133	bile acid	SLC10A2	CHEBI:3098	20494(Tax:10090)	Chemical	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Enterobacteria modulate intestinal bile_acid transport and homeostasis through apical sodium-dependent bile_acid transporter -LRB- SLC10A2 -RRB- expression .
20884752	0	bile_acid	35,44	SLC10A2	126,133	bile acid	SLC10A2	CHEBI:3098	20494(Tax:10090)	Chemical	Gene	transport|amod|START_ENTITY modulate|dobj|transport modulate|nmod|expression expression|appos|END_ENTITY	Enterobacteria modulate intestinal bile_acid transport and homeostasis through apical sodium-dependent bile_acid transporter -LRB- SLC10A2 -RRB- expression .
21649730	0	bile_acid	79,88	SLC10A2	108,115	bile acid	SLC10A2	CHEBI:3098	6555	Chemical	Gene	START_ENTITY|dobj|transporter transporter|appos|ASBT ASBT|dep|END_ENTITY	Functional characterization of genetic variants in the apical sodium-dependent bile_acid transporter -LRB- ASBT ; SLC10A2 -RRB- .
22354836	0	bile_acid	63,72	SLC10A2	93,100	bile acid	SLC10A2	CHEBI:3098	6555	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|hASBT hASBT|dep|END_ENTITY	Putative irreversible inhibitors of the human sodium-dependent bile_acid transporter -LRB- hASBT ; SLC10A2 -RRB- support the role of transmembrane domain 7 in substrate binding/translocation .
24498857	0	bile_acid	46,55	SLC10A2	74,81	bile acid	SLC10A2	CHEBI:3098	6555	Chemical	Gene	ASBT|amod|START_ENTITY ASBT|appos|END_ENTITY	Resveratrol promotes degradation of the human bile_acid transporter ASBT -LRB- SLC10A2 -RRB- .
9109432	0	bile_acid	82,91	SLC10A2	110,117	bile acid	SLC10A2	CHEBI:3098	6555	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Primary bile_acid_malabsorption caused by mutations in the ileal sodium-dependent bile_acid transporter gene -LRB- SLC10A2 -RRB- .
17632081	0	bile_acid	19,28	SLC10A5	41,48	bile acid	SLC10A5	CHEBI:3098	347051	Chemical	Gene	START_ENTITY|ccomp|expressed expressed|nsubjpass|END_ENTITY	The novel putative bile_acid transporter SLC10A5 is highly expressed in liver and kidney .
26838806	0	bile_acid	32,41	Shp	67,70	bile acid	Shp	CHEBI:3098	23957(Tax:10090)	Chemical	Gene	homeostasis|amod|START_ENTITY homeostasis|nmod|END_ENTITY	Bcl2 is a critical regulator of bile_acid homeostasis by dictating Shp and lncRNA H19 function .
23374508	0	bile_acid	154,163	Slc10a2	177,184	bile acid	Slc10a2	CHEBI:3098	20494(Tax:10090)	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Importance of uncharged polar residues and proline in the proximal two-thirds -LRB- Pro107-Ser128 -RRB- of the highly conserved region of mouse ileal Na + - dependent bile_acid transporter , Slc10a2 , in transport activity and cellular expression .
18307294	0	bile_acid	27,36	TGR5	52,56	bile acid	TGR5	CHEBI:3098	151306	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|agonists agonists|nummod|END_ENTITY	Novel potent and selective bile_acid derivatives as TGR5 agonists : biological screening , structure-activity relationships , and molecular modeling studies .
18698841	0	bile_acid	122,131	TGR5	147,151	bile acid	TGR5	CHEBI:3098	151306	Chemical	Gene	recognition|amod|START_ENTITY recognition|nmod|END_ENTITY	Molecular field analysis and 3D-quantitative structure-activity relationship study -LRB- MFA 3D-QSAR -RRB- unveil novel features of bile_acid recognition at TGR5 .
20236244	0	bile_acid	31,40	TGR5	58,62	bile acid	TGR5	CHEBI:3098	227289(Tax:10090)	Chemical	Gene	GpBAR1|amod|START_ENTITY Expression|nmod|GpBAR1 Expression|appos|END_ENTITY	Expression and function of the bile_acid receptor GpBAR1 -LRB- TGR5 -RRB- in the murine enteric nervous system .
21454404	0	bile_acid	22,31	TGR5	42,46	bile acid	TGR5	CHEBI:3098	151306	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	The G protein-coupled bile_acid receptor , TGR5 , stimulates gallbladder_filling .
21735468	0	bile_acid	22,31	TGR5	50,54	bile acid	TGR5	CHEBI:3098	227289(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|Gpbar1 Gpbar1|appos|END_ENTITY	The G-protein-coupled bile_acid receptor , Gpbar1 -LRB- TGR5 -RRB- , negatively regulates hepatic inflammatory response through antagonizing nuclear factor k light-chain enhancer of activated B cells -LRB- NF-kB -RRB- in mice .
21883702	0	bile_acid	15,24	TGR5	34,38	bile acid	TGR5	CHEBI:3098	151306	Chemical	Gene	receptor|amod|START_ENTITY Association|nmod|receptor END_ENTITY|nsubj|Association	Association of bile_acid receptor TGR5 variation and transit in health and lower functional gastrointestinal_disorders .
22046243	0	bile_acid	4,13	TGR5	32,36	bile acid	TGR5	CHEBI:3098	227289(Tax:10090)	Chemical	Gene	GPBAR-1|amod|START_ENTITY GPBAR-1|appos|END_ENTITY	The bile_acid receptor GPBAR-1 -LRB- TGR5 -RRB- modulates integrity of intestinal barrier and immune response to experimental colitis .
22911633	0	bile_acid	32,41	TGR5	59,63	bile acid	TGR5	CHEBI:3098	227289(Tax:10090)	Chemical	Gene	Gpbar1|amod|START_ENTITY Gpbar1|appos|END_ENTITY	Deficiency of G-protein-coupled bile_acid receptor Gpbar1 -LRB- TGR5 -RRB- enhances chemically induced liver_carcinogenesis .
23225346	0	bile_acid	51,60	TGR5	78,82	bile acid	TGR5	CHEBI:3098	151306	Chemical	Gene	GPBAR1|amod|START_ENTITY GPBAR1|appos|END_ENTITY	2-Phenoxy-nicotinamides are potent agonists at the bile_acid receptor GPBAR1 -LRB- TGR5 -RRB- .
23275618	0	bile_acid	32,41	TGR5	52,56	bile acid	TGR5	CHEBI:3098	227289(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Activation of G protein-coupled bile_acid receptor , TGR5 , induces smooth muscle_relaxation via both Epac - and PKA-mediated inhibition of RhoA/Rho kinase pathway .
23578785	0	bile_acid	93,102	TGR5	36,40	bile acid	TGR5	CHEBI:3098	151306	Chemical	Gene	determines|advcl|START_ENTITY determines|nsubj|localization localization|nmod|END_ENTITY	Ciliary subcellular localization of TGR5 determines the cholangiocyte functional response to bile_acid signaling .
23634890	0	bile_acid	4,13	TGR5	24,28	bile acid	TGR5	CHEBI:3098	338443(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	The bile_acid receptor , TGR5 , regulates basal and cholinergic-induced secretory responses in rat colon .
23686672	0	bile_acid	42,51	TGR5	13,17	bile acid	TGR5	CHEBI:3098	227289(Tax:10090)	Chemical	Gene	overload|amod|START_ENTITY liver|nmod|overload protects|dobj|liver protects|nsubj|END_ENTITY	The receptor TGR5 protects the liver from bile_acid overload during liver_regeneration in mice .
23996693	0	bile_acid	58,67	TGR5	85,89	bile acid	TGR5	CHEBI:3098	151306	Chemical	Gene	Gpbar1|amod|START_ENTITY Gpbar1|appos|END_ENTITY	Retraction statement : The deficiency of G-protein-coupled bile_acid receptor Gpbar1 -LRB- TGR5 -RRB- enhances chemically-induced liver_carcinogenesis .
24411485	0	bile_acid	4,13	TGR5	14,18	bile acid	TGR5	CHEBI:3098	151306	Chemical	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	The bile_acid TGR5 membrane receptor : from basic research to clinical application .
24465162	0	bile_acid	46,55	TGR5	73,77	bile acid	TGR5	CHEBI:3098	151306	Chemical	Gene	Gpbar1|amod|START_ENTITY Gpbar1|appos|END_ENTITY	Aberrant DNA methylation of G-protein-coupled bile_acid receptor Gpbar1 -LRB- TGR5 -RRB- is a potential biomarker for hepatitis_B Virus associated hepatocellular_carcinoma .
24821328	2	bile_acid	425,434	TGR5	461,465	bile acid	TGR5	CHEBI:3098	151306	Chemical	Gene	START_ENTITY|ccomp|opened opened|nsubj|receptor receptor|dep|known known|nmod|END_ENTITY	The identification of the farnesoid_X_receptor -LRB- FXR -RRB- as a nuclear receptor directly activated by bile_acids and the discovery that bile_acids are also ligands for the membrane-bound , G-protein coupled bile_acid receptor 1 -LRB- also known as TGR5 -RRB- have opened new avenues of research .
26417930	0	bile_acid	22,31	TGR5	49,53	bile acid	TGR5	CHEBI:3098	151306	Chemical	Gene	Gpbar1|amod|START_ENTITY Gpbar1|appos|END_ENTITY	The G-protein-coupled bile_acid receptor Gpbar1 -LRB- TGR5 -RRB- suppresses gastric_cancer cell proliferation and migration through antagonizing STAT3 signaling pathway .
17054913	0	bile_acid	80,89	VDR	73,76	bile acid	VDR	CHEBI:3098	24873(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY END_ENTITY|nmod|synthesis	Inhibition of LXRalpha signaling by vitamin_D_receptor : possible role of VDR in bile_acid synthesis .
12810816	0	bile_acid	20,29	apoE	71,75	bile acid	apoE	CHEBI:3098	11816(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Inhibition of ileal bile_acid transport and reduced atherosclerosis in apoE - / - mice by SC-435 .
1805095	0	bile_acid	77,86	cholesterol_7_alpha-hydroxylase	98,129	bile acid	cholesterol 7 alpha-hydroxylase	CHEBI:3098	25428(Tax:10116)	Chemical	Gene	acyltransferase|amod|START_ENTITY acyltransferase|amod|END_ENTITY	Effects of perturbations in hepatic free and esterified cholesterol pools on bile_acid synthesis , cholesterol_7_alpha-hydroxylase , HMG-CoA_reductase , acyl-CoA : cholesterol acyltransferase and cytosolic cholesteryl_ester hydrolase .
2335522	0	bile_acid	87,96	cholesterol_7_alpha-hydroxylase	26,57	bile acid	cholesterol 7 alpha-hydroxylase	CHEBI:3098	25428(Tax:10116)	Chemical	Gene	biosynthesis|amod|START_ENTITY enzyme|nmod|biosynthesis END_ENTITY|appos|enzyme	Cloning and regulation of cholesterol_7_alpha-hydroxylase , the rate-limiting enzyme in bile_acid biosynthesis .
6545072	0	bile_acid	110,119	cholesterol_7_alpha-hydroxylase	49,80	bile acid	cholesterol 7 alpha-hydroxylase	CHEBI:3098	25428(Tax:10116)	Chemical	Gene	biosynthesis|amod|START_ENTITY enzyme|nmod|biosynthesis END_ENTITY|appos|enzyme	Role of glutathione in the regulation of hepatic cholesterol_7_alpha-hydroxylase , the rate-limiting enzyme of bile_acid biosynthesis .
12562858	0	bile_acid	82,91	cholesterol_7alpha-hydroxylase	19,49	bile acid	cholesterol 7alpha-hydroxylase	CHEBI:3098	1581	Chemical	Gene	START_ENTITY|nsubj|activity activity|amod|END_ENTITY	Monitoring hepatic cholesterol_7alpha-hydroxylase activity by assay of the stable bile_acid intermediate 7alpha-hydroxy-4-cholesten-3-one in peripheral blood .
15736936	0	bile_acid	60,69	cytochrome_P450_7A1	23,42	bile acid	cytochrome P450 7A1	CHEBI:3098	1581	Chemical	Gene	biosynthesis|amod|START_ENTITY enzyme|nmod|biosynthesis END_ENTITY|appos|enzyme	Cholesterol binding to cytochrome_P450_7A1 , a key enzyme in bile_acid biosynthesis .
9660774	0	bile_acid	102,111	cytochrome_P450c27	32,50	bile acid	cytochrome P450c27	CHEBI:3098	1593	Chemical	Gene	START_ENTITY|nsubj|Activities Activities|nmod|END_ENTITY	Activities of recombinant human cytochrome_P450c27 -LRB- CYP27 -RRB- which produce intermediates of alternative bile_acid biosynthetic pathways .
8420979	0	bile_acid	48,57	ecto-ATPase	14,25	bile acid	ecto-ATPase	CHEBI:3098	81613(Tax:10116)	Chemical	Gene	protein|amod|START_ENTITY protein|nsubj|END_ENTITY	The rat liver ecto-ATPase is also a canalicular bile_acid transport protein .
9207285	0	bile_acid	30,39	ecto-ATPase	91,102	bile acid	ecto-ATPase	CHEBI:3098	81613(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|protein protein|nmod|END_ENTITY	Evidence for an ATP-dependent bile_acid transport protein other than the canalicular liver ecto-ATPase in rats .
15466244	0	bile_acid	63,72	farnesoid_X_receptor	8,28	bile acid	farnesoid X receptor	CHEBI:3098	20186(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of farnesoid_X_receptor in the enhancement of canalicular bile_acid output and excretion of unconjugated bile_acids : a mechanism for protection against cholic_acid-induced liver_toxicity .
17720959	0	bile_acid	27,36	farnesoid_X_receptor	56,76	bile acid	farnesoid X receptor	CHEBI:3098	20186(Tax:10090)	Chemical	Gene	regulation|nmod|START_ENTITY homeostasis|nsubj|regulation homeostasis|nmod|END_ENTITY	Differential regulation of bile_acid homeostasis by the farnesoid_X_receptor in liver and intestine .
25511198	0	bile_acid	8,17	farnesoid_X_receptor	40,60	bile acid	farnesoid X receptor	CHEBI:3098	9971	Chemical	Gene	START_ENTITY|xcomp|signaling signaling|nmod|END_ENTITY	Nuclear bile_acid signaling through the farnesoid_X_receptor .
22003820	0	bile_acid	24,33	fibroblast_growth_factor_19	124,151	bile acid	fibroblast growth factor 19	CHEBI:3098	9965	Chemical	Gene	synthesis|amod|START_ENTITY variation|nmod|synthesis related|nsubjpass|variation related|nmod|levels levels|nmod|END_ENTITY	Pronounced variation in bile_acid synthesis in humans is related to gender , hypertriglyceridaemia and circulating levels of fibroblast_growth_factor_19 .
24134500	0	bile_acid	57,66	fibroblast_growth_factor_19	12,39	bile acid	fibroblast growth factor 19	CHEBI:3098	9965	Chemical	Gene	diarrhoea|amod|START_ENTITY patients|nmod|diarrhoea END_ENTITY|nmod|patients	Commentary : fibroblast_growth_factor_19 in patients with bile_acid diarrhoea .
25360305	0	bile_acid	24,33	fibroblast_growth_factor_19	48,75	bile acid	fibroblast growth factor 19	CHEBI:3098	9965	Chemical	Gene	synthesis|amod|START_ENTITY synthesis|nmod|END_ENTITY	Upregulation of hepatic bile_acid synthesis via fibroblast_growth_factor_19 is defective in gallstone_disease but functional in overweight individuals .
26256900	0	bile_acid	29,38	fibroblast_growth_factor_19	75,102	bile acid	fibroblast growth factor 19	CHEBI:3098	9965	Chemical	Gene	synthesis|amod|START_ENTITY Effect|nmod|synthesis Effect|nmod|END_ENTITY	Effect of cholecystectomy on bile_acid synthesis and circulating levels of fibroblast_growth_factor_19 .
16078136	0	bile_acid	93,102	hASBT	116,121	bile acid	hASBT	CHEBI:3098	6555	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Development of stably transfected monolayer overexpressing the human apical sodium-dependent bile_acid transporter -LRB- hASBT -RRB- .
16783481	0	bile_acid	68,77	hASBT	91,96	bile acid	hASBT	CHEBI:3098	6555	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Interaction of native bile_acids with human apical sodium-dependent bile_acid transporter -LRB- hASBT -RRB- : influence of steroidal_hydroxylation pattern and C-24 conjugation .
19384469	0	bile_acid	61,70	hASBT	84,89	bile acid	hASBT	CHEBI:3098	6555	Chemical	Gene	START_ENTITY|dobj|transporter transporter|appos|END_ENTITY	Inhibition requirements of the human apical sodium-dependent bile_acid transporter -LRB- hASBT -RRB- using aminopiperidine conjugates of glutamyl-bile_acids .
20848648	0	bile_acid	103,112	hASBT	126,131	bile acid	hASBT	CHEBI:3098	6555	Chemical	Gene	START_ENTITY|dobj|transporter transporter|appos|END_ENTITY	Synthesis and in vitro evaluation of gabapentin prodrugs that target the human apical sodium-dependent bile_acid transporter -LRB- hASBT -RRB- .
22354836	0	bile_acid	63,72	hASBT	86,91	bile acid	hASBT	CHEBI:3098	6555	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Putative irreversible inhibitors of the human sodium-dependent bile_acid transporter -LRB- hASBT ; SLC10A2 -RRB- support the role of transmembrane domain 7 in substrate binding/translocation .
24328955	0	bile_acid	54,63	hASBT	77,82	bile acid	hASBT	CHEBI:3098	6555	Chemical	Gene	START_ENTITY|dobj|transporter transporter|dep|END_ENTITY	Structural requirements of the human sodium-dependent bile_acid transporter -LRB- hASBT -RRB- : role of 3 - and 7-OH moieties on binding and translocation of bile_acids .
8132567	0	bile_acid	120,129	hepatic_dihydrodiol_dehydrogenase	67,100	bile acid	hepatic dihydrodiol dehydrogenase	CHEBI:3098	1645	Chemical	Gene	START_ENTITY|nsubj|organization organization|nmod|END_ENTITY	Genomic organization and chromosomal localization of a novel human hepatic_dihydrodiol_dehydrogenase with high affinity bile_acid binding .
11551957	0	bile_acid	88,97	leptin	139,145	bile acid	leptin	CHEBI:3098	16846(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|treatment treatment|compound|END_ENTITY	Transcriptional profiling reveals global defects in energy metabolism , lipoprotein , and bile_acid synthesis and transport with reversal by leptin treatment in ob/ob mouse liver .
24154606	0	bile_acid	105,114	multidrug_resistance-associated_proteins_3_and_4	128,176	bile acid	multidrug resistance-associated proteins 3 and 4	CHEBI:3098	8714	Chemical	Gene	transporters|amod|START_ENTITY transporters|amod|END_ENTITY	Risk factors for development of cholestatic drug-induced_liver_injury : inhibition of hepatic basolateral bile_acid transporters multidrug_resistance-associated_proteins_3_and_4 .
10385660	0	bile_acid	25,34	ntcp	90,94	bile acid	ntcp	CHEBI:3098	24777(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY uptake|nsubj|regulation uptake|nmod|translocation translocation|nmod|END_ENTITY	Short-term regulation of bile_acid uptake by microfilament-dependent translocation of rat ntcp to the plasma membrane .
11438503	0	bile_acid	83,92	ntcp	106,110	bile acid	ntcp	CHEBI:3098	24777(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	The orphan nuclear receptor , shp , mediates bile_acid-induced inhibition of the rat bile_acid transporter , ntcp .
17603092	0	bile_acid	14,23	p38_mitogen-activated_protein_kinase	44,80	bile acid	p38 mitogen-activated protein kinase	CHEBI:3098	1432	Chemical	Gene	biosynthesis|amod|START_ENTITY biosynthesis|nmod|END_ENTITY	Activation of bile_acid biosynthesis by the p38_mitogen-activated_protein_kinase -LRB- MAPK -RRB- : hepatocyte_nuclear_factor-4alpha phosphorylation by the p38 MAPK is required for cholesterol_7alpha-hydroxylase expression .
12649089	0	bile_acid	16,25	phospholipid_transfer_protein	89,118	bile acid	phospholipid transfer protein	CHEBI:3098	5360	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Increased fecal bile_acid excretion in transgenic_mice with elevated expression of human phospholipid_transfer_protein .
17483744	0	bile_acid	60,69	retinoid-X_receptor-alpha	8,33	bile acid	retinoid-X receptor-alpha	CHEBI:3098	25271(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of retinoid-X_receptor-alpha in the suppression of rat bile_acid coenzyme A-amino_acid_N-acyltransferase in liver during sepsis .
12487922	0	bile_acid	57,66	vascular_endothelial_growth_factor	17,51	bile acid	vascular endothelial growth factor	CHEBI:3098	7422	Chemical	Gene	Relationship|nmod|START_ENTITY Relationship|nmod|END_ENTITY	-LSB- Relationship of vascular_endothelial_growth_factor with bile_acid in intrahepatic cholestasis_of_pregnancy -RSB- .
6944415	0	bile_acids	27,37	3_alpha-hydroxysteroid_dehydrogenase	60,96	bile acids	3 alpha-hydroxysteroid dehydrogenase	MESH:D001647	291283(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|cells cells|nmod|END_ENTITY	Enzymatic determination of bile_acids from liver cells with 3_alpha-hydroxysteroid_dehydrogenase -- a warning .
25446997	0	bile_acids	6,16	ABCG2	80,85	bile acids	ABCG2	MESH:D001647	9429	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Total bile_acids in the maternal and fetal compartment in relation to placental ABCG2 expression in preeclamptic pregnancies complicated by HELLP_syndrome .
21081494	0	bile_acids	62,72	AKR1B7	0,6	bile acids	AKR1B7	MESH:D001647	11997(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	AKR1B7 is induced by the farnesoid_X_receptor and metabolizes bile_acids .
17604323	0	bile_acids	32,42	COX-2	0,5	bile acids	COX-2	MESH:D001647	26198(Tax:10116)	Chemical	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	COX-2 induction by unconjugated bile_acids involves reactive_oxygen_species-mediated signalling pathways in Barrett 's _ oesophagus and oesophageal_adenocarcinoma .
12957378	0	bile_acids	60,70	CYP27A1	48,55	bile acids	CYP27A1	MESH:D001647	1593	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of human sterol_27-hydroxylase gene -LRB- CYP27A1 -RRB- by bile_acids and hepatocyte_nuclear_factor_4alpha -LRB- HNF4alpha -RRB- .
21459580	0	bile_acids	17,27	FXR	31,34	bile acids	FXR	MESH:D001647	9971	Chemical	Gene	START_ENTITY|nmod|ligands ligands|compound|END_ENTITY	Extending SAR of bile_acids as FXR ligands : discovery of 23-N - -LRB- carbocinnamyloxy -RRB- -3 a,7a-dihydroxy-6a-ethyl-24-nor-5b-cholan-23-amine .
21988803	0	bile_acids	10,20	FXR	67,70	bile acids	FXR	MESH:D001647	9971	Chemical	Gene	Impact|nmod|START_ENTITY Impact|nmod|END_ENTITY	Impact of bile_acids on the growth of human cholangiocarcinoma via FXR .
15375181	0	bile_acids	75,85	Megalin	0,7	bile acids	Megalin	MESH:D001647	14725(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Megalin and cubilin expression in gallbladder epithelium and regulation by bile_acids .
23872533	0	bile_acids	97,107	STARD5	111,117	bile acids	STARD5	MESH:D001647	80765	Chemical	Gene	the|nmod|START_ENTITY the|nmod|END_ENTITY	Thermodynamic and solution state NMR characterization of the binding of secondary and conjugated bile_acids to STARD5 .
23041323	0	bile_acids	64,74	TGR5	13,17	bile acids	TGR5	MESH:D001647	227289(Tax:10090)	Chemical	Gene	actions|nmod|START_ENTITY mediates|dobj|actions mediates|nsubj|END_ENTITY	The receptor TGR5 mediates the prokinetic actions of intestinal bile_acids and is required for normal defecation in mice .
9277417	0	bile_acids	102,112	alkaline_phosphatase	36,56	bile acids	alkaline phosphatase	MESH:D001647	403548(Tax:9615)	Chemical	Gene	circulation|nmod|START_ENTITY coincident|nmod|circulation coincident|compound|END_ENTITY	CCK-8 infusion increases plasma LMW alkaline_phosphatase coincident with enterohepatic circulation of bile_acids .
9715409	0	bile_acids	78,88	alkaline_phosphatase	14,34	bile acids	alkaline phosphatase	MESH:D001647	250	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of alkaline_phosphatase gene expression in human hepatoma cells by bile_acids .
2227820	5	bile_acids	841,851	cholesterol_7_alpha-hydroxylase	751,782	bile acids	cholesterol 7 alpha-hydroxylase	MESH:D001647	448985(Tax:9823)	Chemical	Gene	7_alpha-hydroxycholesterol|nmod|START_ENTITY _|amod|7_alpha-hydroxycholesterol conversion|nmod|_ affected|nsubjpass|conversion exerted|advcl|affected exerted|nmod|activity activity|nmod|END_ENTITY	The inhibitory action was exerted specifically on activity of cholesterol_7_alpha-hydroxylase because conversion of -LSB- 14C -RSB- _ 7_alpha-hydroxycholesterol to bile_acids by pig hepatocytes was not affected .
35860	0	bile_acids	14,24	cholesterol_7_alpha-hydroxylase	42,73	bile acids	cholesterol 7 alpha-hydroxylase	MESH:D001647	448985(Tax:9823)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	The effect of bile_acids on `` solubilized '' cholesterol_7_alpha-hydroxylase activity in swine .
4190898	0	bile_acids	9,19	cholesterol_7_alpha-hydroxylase	41,72	bile acids	cholesterol 7 alpha-hydroxylase	MESH:D001647	1581	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Role of bile_acids in the regulation of cholesterol_7_alpha-hydroxylase -RSB- .
7666012	0	bile_acids	63,73	cholesterol_7_alpha-hydroxylase	14,45	bile acids	cholesterol 7 alpha-hydroxylase	MESH:D001647	25428(Tax:10116)	Chemical	Gene	transcription|nmod|START_ENTITY transcription|amod|END_ENTITY	Repression of cholesterol_7_alpha-hydroxylase transcription by bile_acids is mediated through protein kinase C in primary cultures of rat hepatocytes .
7737153	0	bile_acids	22,32	cholesterol_7_alpha-hydroxylase	63,94	bile acids	cholesterol 7 alpha-hydroxylase	MESH:D001647	25428(Tax:10116)	Chemical	Gene	aspects|nmod|START_ENTITY involved|nsubj|aspects involved|nmod|regulation regulation|acl|END_ENTITY	Structural aspects of bile_acids involved in the regulation of cholesterol_7_alpha-hydroxylase and sterol_27-hydroxylase .
8297364	0	bile_acids	11,21	cholesterol_7_alpha-hydroxylase	72,103	bile acids	cholesterol 7 alpha-hydroxylase	MESH:D001647	25428(Tax:10116)	Chemical	Gene	hormones|amod|START_ENTITY Effects|nmod|hormones Effects|nmod|expression expression|nmod|mRNA mRNA|amod|END_ENTITY	Effects of bile_acids and steroid/thyroid hormones on the expression of cholesterol_7_alpha-hydroxylase mRNA and the CYP7 gene in HepG2 cells .
8314765	0	bile_acids	81,91	cholesterol_7_alpha-hydroxylase	30,61	bile acids	cholesterol 7 alpha-hydroxylase	MESH:D001647	25428(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|mRNA mRNA|amod|END_ENTITY	Transcriptional regulation of cholesterol_7_alpha-hydroxylase mRNA by conjugated bile_acids in primary cultures of rat hepatocytes .
8314765	6	bile_acids	1025,1035	cholesterol_7_alpha-hydroxylase	1072,1103	bile acids	Cholesterol 7 alpha-hydroxylase	MESH:D001647	25428(Tax:10116)	Chemical	Gene	nor|dobj|START_ENTITY bile_acid|parataxis|nor bile_acid|dobj|mRNA mRNA|amod|END_ENTITY	Hydrophilic bile_acid analogues -LRB- nor -LRB- C23 -RRB- bile_acids and beta-hydroxy epimers -RRB- repressed cholesterol_7_alpha-hydroxylase mRNA less potently than their corresponding and more hydrophobic C24 or alpha-hydroxy derivatives .
8457195	0	bile_acids	109,119	cholesterol_7_alpha-hydroxylase	36,67	bile acids	cholesterol 7 alpha-hydroxylase	MESH:D001647	25428(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|mRNA mRNA|amod|END_ENTITY	Differential feedback regulation of cholesterol_7_alpha-hydroxylase mRNA and transcriptional activity by rat bile_acids in primary monolayer cultures of rat hepatocytes .
8770045	0	bile_acids	46,56	cholesterol_7_alpha-hydroxylase	89,120	bile acids	cholesterol 7 alpha-hydroxylase	MESH:D001647	25428(Tax:10116)	Chemical	Gene	activation|nmod|START_ENTITY activation|dep|implications implications|nmod|regulation regulation|nmod|END_ENTITY	Hepatocellular protein_kinase_C activation by bile_acids : implications for regulation of cholesterol_7_alpha-hydroxylase .
11278771	0	bile_acids	78,88	cholesterol_7alpha-hydroxylase	19,49	bile acids	cholesterol 7alpha-hydroxylase	MESH:D001647	25428(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Down-regulation of cholesterol_7alpha-hydroxylase -LRB- CYP7A1 -RRB- gene expression by bile_acids in primary rat hepatocytes is mediated by the c-Jun N-terminal kinase pathway .
11402042	0	bile_acids	24,34	cholesterol_7alpha-hydroxylase	91,121	bile acids	cholesterol 7alpha-hydroxylase	MESH:D001647	1581	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|transcription transcription|nmod|gene gene|amod|END_ENTITY	The negative effects of bile_acids and tumor_necrosis_factor-alpha on the transcription of cholesterol_7alpha-hydroxylase gene -LRB- CYP7A1 -RRB- converge to hepatic nuclear factor-4 : a novel mechanism of feedback regulation of bile_acid synthesis mediated by nuclear receptors .
11518759	0	bile_acids	99,109	cholesterol_7alpha-hydroxylase	46,76	bile acids	cholesterol 7alpha-hydroxylase	MESH:D001647	1581	Chemical	Gene	transcription|nmod|START_ENTITY transcription|nsubj|repression repression|nmod|gene gene|amod|END_ENTITY	Nuclear receptor-mediated repression of human cholesterol_7alpha-hydroxylase gene transcription by bile_acids .
9371693	0	bile_acids	143,153	cholesterol_7alpha-hydroxylase	40,70	bile acids	cholesterol 7alpha-hydroxylase	MESH:D001647	13122(Tax:10090)	Chemical	Gene	regulation|nmod|START_ENTITY responsive|nmod|regulation contains|xcomp|responsive contains|nsubj|region region|nmod|mRNA mRNA|amod|END_ENTITY	The 3 ' - untranslated region of the mouse cholesterol_7alpha-hydroxylase mRNA contains elements responsive to post-transcriptional regulation by bile_acids .
17431217	0	bile_acids	55,65	cyclin_D1	27,36	bile acids	cyclin D1	MESH:D001647	58919(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of cyclin_D1 and cell death by bile_acids in primary rat hepatocytes .
11729118	0	bile_acids	103,113	cyclooxygenase-2	24,40	bile acids	cyclooxygenase-2	MESH:D001647	29527(Tax:10116)	Chemical	Gene	involvement|nmod|START_ENTITY evidence|nmod|involvement mucosa|dep|evidence END_ENTITY|nmod|mucosa	Duodenal_reflux induces cyclooxygenase-2 in the esophageal mucosa of rats : evidence for involvement of bile_acids .
24914375	0	bile_acids	11,21	cyclooxygenase-2	25,41	bile acids	cyclooxygenase-2	MESH:D001647	29527(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effects of bile_acids on cyclooxygenase-2 expression in a rat model of duodenoesophageal anastomosis .
24465600	0	bile_acids	56,66	fibroblast_growth_factor_19	14,41	bile acids	fibroblast growth factor 19	MESH:D001647	9965	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|expression expression|amod|END_ENTITY	Modulation of fibroblast_growth_factor_19 expression by bile_acids , meal replacement and energy drinks , milk , and coffee .
6133860	0	bile_acids	56,66	gamma-glutamyl_transpeptidase	14,43	bile acids	gamma-glutamyl transpeptidase	MESH:D001647	92086	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|activity activity|amod|END_ENTITY	Modulation of gamma-glutamyl_transpeptidase activity by bile_acids .
7325958	0	bile_acids	43,53	glutathione_S-transferase	14,39	bile acids	glutathione S-transferase	MESH:D001647	58962(Tax:10116)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of glutathione_S-transferase by bile_acids .
25873431	0	bile_acids	10,20	hTERT	30,35	bile acids	hTERT	MESH:D001647	7015	Chemical	Gene	START_ENTITY|dobj|expression expression|compound|END_ENTITY	Acidified bile_acids increase hTERT expression via c-myc activation in human gastric_cancer cells .
25873431	0	bile_acids	10,20	hTERT	30,35	bile acids	hTERT	MESH:D001647	7015	Chemical	Gene	START_ENTITY|dobj|expression expression|compound|END_ENTITY	Acidified bile_acids increase hTERT expression via c-myc activation in human gastric_cancer cells .
2828498	0	bile_acids	59,69	low_density_lipoprotein_receptor	14,46	bile acids	low density lipoprotein receptor	MESH:D001647	3949	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Modulation of low_density_lipoprotein_receptor activity by bile_acids : differential effects of chenodeoxycholic and ursodeoxycholic_acids in the hamster .
15358635	0	bile_acids	106,116	macrophage_migration_inhibitory_factor	14,52	bile acids	macrophage migration inhibitory factor	MESH:D001647	4282	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of macrophage_migration_inhibitory_factor in esophageal_squamous_cell_carcinoma and effects of bile_acids and NSAIDs .
17898130	0	bile_acids	75,85	protein_kinase_C-delta	8,30	bile acids	protein kinase C-delta	MESH:D001647	5580	Chemical	Gene	action|nmod|START_ENTITY Role|nmod|action Role|nmod|END_ENTITY	Role of protein_kinase_C-delta in the age-dependent secretagogue action of bile_acids in mammalian colon .
9458268	0	bile_acids	50,60	protein_kinase_C_alpha	14,36	bile acids	protein kinase C alpha	MESH:D001647	24680(Tax:10116)	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of protein_kinase_C_alpha and delta by bile_acids : correlation with bile_acid structure and diacylglycerol formation .
10528998	0	bile_acids	65,75	sterol_27-hydroxylase	35,56	bile acids	sterol 27-hydroxylase	MESH:D001647	301517(Tax:10116)	Chemical	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Down-regulation of the rat hepatic sterol_27-hydroxylase gene by bile_acids in transfected primary hepatocytes : possible role of hepatic_nuclear_factor_1alpha .
12957378	0	bile_acids	60,70	sterol_27-hydroxylase	20,41	bile acids	sterol 27-hydroxylase	MESH:D001647	1593	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|gene gene|amod|END_ENTITY	Regulation of human sterol_27-hydroxylase gene -LRB- CYP27A1 -RRB- by bile_acids and hepatocyte_nuclear_factor_4alpha -LRB- HNF4alpha -RRB- .
7832767	0	bile_acids	74,84	sterol_27-hydroxylase	15,36	bile acids	sterol 27-hydroxylase	MESH:D001647	301517(Tax:10116)	Chemical	Gene	mRNA|nmod|START_ENTITY mRNA|amod|END_ENTITY	Suppression of sterol_27-hydroxylase mRNA and transcriptional activity by bile_acids in cultured rat hepatocytes .
8928794	0	bile_acids	63,73	sterol_27-hydroxylase	38,59	bile acids	sterol 27-hydroxylase	MESH:D001647	301517(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of hepatic sterol_27-hydroxylase by bile_acids .
25680200	7	bile_salt	994,1003	Cftr	1021,1025	bile salt	Cftr	CHEBI:3098	12638(Tax:10090)	Chemical	Gene	concentration|amod|START_ENTITY concentration|nmod|END_ENTITY	However , chronic cholate exposure increased the bile flow significantly less in Cftr - / - mice than in controls , together with significantly higher biliary bile_salt concentration in Cftr - / - mice .
21507240	0	bile_salt	8,17	Mcl-1	32,37	bile salt	Mcl-1	CHEBI:3098	4170	Chemical	Gene	START_ENTITY|acl|regulating regulating|dobj|END_ENTITY	Role of bile_salt in regulating Mcl-1 phosphorylation and chemoresistance in hepatocellular_carcinoma cells .
12055195	0	bile_salt	30,39	SLC10A2	58,65	bile salt	SLC10A2	CHEBI:3098	6555	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Human apical sodium-dependent bile_salt transporter gene -LRB- SLC10A2 -RRB- is regulated by the peroxisome_proliferator-activated_receptor_alpha .
22669917	0	bile_salt	43,52	SLC10A2	71,78	bile salt	SLC10A2	CHEBI:3098	6555	Chemical	Gene	ASBT|amod|START_ENTITY ASBT|appos|END_ENTITY	Evolution of substrate specificity for the bile_salt transporter ASBT -LRB- SLC10A2 -RRB- .
23752471	0	bile_salt	76,85	SLC10A2	99,106	bile salt	SLC10A2	CHEBI:3098	6555	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Arylsulfonylamino-benzanilides as inhibitors of the apical sodium-dependent bile_salt transporter -LRB- SLC10A2 -RRB- .
9828229	0	bile_salt	133,142	Spgp	156,160	bile salt	Spgp	CHEBI:3098	83569(Tax:10116)	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Up-regulation of the multidrug resistance genes , Mrp1 and Mdr1b , and down-regulation of the organic anion transporter , Mrp2 , and the bile_salt transporter , Spgp , in endotoxemic rat liver .
2775770	0	bile_salt	75,84	cholesterol_esterase	32,52	bile salt	cholesterol esterase	CHEBI:3098	24254(Tax:10116)	Chemical	Gene	liver|nmod|START_ENTITY END_ENTITY|nmod|liver	Identity of a cytosolic neutral cholesterol_esterase in rat liver with the bile_salt stimulated cholesterol_esterase in pancreas .
2775770	0	bile_salt	75,84	cholesterol_esterase	96,116	bile salt	cholesterol esterase	CHEBI:3098	24254(Tax:10116)	Chemical	Gene	liver|nmod|START_ENTITY cholesterol_esterase|nmod|liver Identity|nmod|cholesterol_esterase stimulated|nsubj|Identity stimulated|xcomp|END_ENTITY	Identity of a cytosolic neutral cholesterol_esterase in rat liver with the bile_salt stimulated cholesterol_esterase in pancreas .
11336352	0	bile_salt	15,24	mucin	68,73	bile salt	mucin	CHEBI:3098	404104(Tax:9913)	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of bile_salt and phospholipids with bovine submaxillary mucin .
11518575	0	bile_salt	29,38	mucin	79,84	bile salt	mucin	CHEBI:3098	65202(Tax:10116)	Chemical	Gene	diffusion|nmod|START_ENTITY Analysis|nmod|diffusion Analysis|dep|micelles micelles|nmod|END_ENTITY	Analysis of the diffusion of bile_salt / phospholipid micelles in rat intestinal mucin .
8710742	0	bile_salt	15,24	mucin	52,57	bile salt	mucin	CHEBI:3098	404104(Tax:9913)	Chemical	Gene	aggregates|nmod|START_ENTITY aggregates|nmod|END_ENTITY	Diffusivity of bile_salt / phospholipid aggregates in mucin .
1876599	0	bile_salt	25,34	peptide_YY	57,67	bile salt	peptide YY	CHEBI:3098	607156(Tax:9615)	Chemical	Gene	infusion|nmod|START_ENTITY stimulates|nsubj|infusion stimulates|dobj|release release|nmod|END_ENTITY	Intracolonic infusion of bile_salt stimulates release of peptide_YY and inhibits cholecystokinin-stimulated pancreatic exocrine secretion in conscious dogs .
6708561	0	bile_salt	15,24	sulfatase	25,34	bile salt	sulfatase	CHEBI:3098	347527	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Specificity of bile_salt sulfatase activity in man , mouse and rat intestinal microflora .
21920435	0	bile_salts	59,69	Cj0561c	20,27	bile salts	Cj0561c	MESH:D001647	905206(Tax:192222)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	CmeR-dependent gene Cj0561c is induced more effectively by bile_salts than the CmeABC efflux pump in both human and poultry Campylobacter_jejuni strains .
10915741	0	bile_salts	66,76	P-glycoprotein	37,51	bile salts	P-glycoprotein	MESH:D001647	287115(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of multidrug_resistance_2 P-glycoprotein expression by bile_salts in rats and in primary cultures of rat hepatocytes .
9020871	0	bile_salts	48,58	P-glycoprotein	19,33	bile salts	P-glycoprotein	MESH:D001647	67078(Tax:10090)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of mdr2 P-glycoprotein expression by bile_salts .
812551	0	bile_salts	10,20	beta-galactosidase	41,59	bile salts	beta-galactosidase	MESH:D001647	2720	Chemical	Gene	START_ENTITY|nmod|activities activities|amod|END_ENTITY	Effect of bile_salts on lactosylceramide beta-galactosidase activities in human brain , liver and cultured skin fibroblasts .
8138269	0	bile_salts	21,31	cholesterol_7_alpha-hydroxylase	92,123	bile salts	cholesterol 7 alpha-hydroxylase	MESH:D001647	25428(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of different bile_salts on steady-state mRNA levels and transcriptional activity of cholesterol_7_alpha-hydroxylase .
7379678	0	bile_salts	33,43	gastrin	61,68	bile salts	gastrin	MESH:D001647	2520	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Effect of antral instillation of bile_salts on fasting serum gastrin levels .
7719401	0	bile_salts	105,115	gastrin	46,53	bile salts	gastrin	MESH:D001647	25320(Tax:10116)	Chemical	Gene	administration|nmod|START_ENTITY provoked|nmod|administration provoked|nsubj|Involvement Involvement|nmod|neurons neurons|nmod|release release|compound|END_ENTITY	Involvement of capsaicin-sensitive neurons in gastrin release provoked by intragastric administration of bile_salts in the rat .
9508530	0	bile_salts	38,48	intestinal_alkaline_sphingomyelinase	66,102	bile salts	intestinal alkaline sphingomyelinase	MESH:D001647	303729(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|nmod|END_ENTITY	Effects of ursodeoxycholate and other bile_salts on levels of rat intestinal_alkaline_sphingomyelinase : a potential implication in tumorigenesis .
8869755	0	bile_salts	13,23	mdr2	35,39	bile salts	mdr2	MESH:D001647	18670(Tax:10090)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|expression expression|amod|END_ENTITY	Influence of bile_salts on hepatic mdr2 P-glycoprotein expression .
9020871	0	bile_salts	48,58	mdr2	14,18	bile salts	mdr2	MESH:D001647	18670(Tax:10090)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of mdr2 P-glycoprotein expression by bile_salts .
10644759	0	bile_salts	27,37	multidrug_resistance-associated_protein_3	45,86	bile salts	multidrug resistance-associated protein 3	MESH:D001647	140668(Tax:10116)	Chemical	Gene	transport|nmod|START_ENTITY transport|nmod|END_ENTITY	ATP-dependent transport of bile_salts by rat multidrug_resistance-associated_protein_3 -LRB- Mrp3 -RRB- .
10915741	0	bile_salts	66,76	multidrug_resistance_2	14,36	bile salts	multidrug resistance 2	MESH:D001647	24891(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of multidrug_resistance_2 P-glycoprotein expression by bile_salts in rats and in primary cultures of rat hepatocytes .
17615180	0	bile_salts	39,49	p63	18,21	bile salts	p63	MESH:D001647	8626	Chemical	Gene	Downregulation|nmod|START_ENTITY Downregulation|nmod|END_ENTITY	Downregulation of p63 upon exposure to bile_salts and acid in normal and cancer esophageal cells in culture .
7433910	0	bile_salts	15,25	secretin	49,57	bile salts	secretin	MESH:D001647	6343	Chemical	Gene	release|nsubj|START_ENTITY release|dobj|END_ENTITY	Pure synthetic bile_salts release immunoreactive secretin in man .
10404808	0	biliopancreatic_diversion	27,52	leptin	7,13	biliopancreatic diversion	leptin	null	3952	Chemical	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	Plasma leptin levels after biliopancreatic_diversion : dissociation with body mass index .
6457373	0	bilirubin	10,19	ATPase	23,29	bilirubin	ATPase	MESH:D001663	1769	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|compound|END_ENTITY	Effect of bilirubin on ATPase activity of human erythrocyte membranes .
20334601	0	bilirubin	34,43	C-reactive_protein	0,18	bilirubin	C-reactive protein	MESH:D001663	1401	Chemical	Gene	superior|xcomp|START_ENTITY superior|nsubj|END_ENTITY	C-reactive_protein is superior to bilirubin for anticipation of perforation in acute_appendicitis .
19150444	0	bilirubin	13,22	C1_esterase	32,43	bilirubin	C1 esterase	MESH:D001663	716	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Unconjugated bilirubin inhibits C1_esterase activity .
11274970	0	bilirubin	31,40	Cyp1a2	64,70	bilirubin	Cyp1a2	MESH:D001663	13077(Tax:10090)	Chemical	Gene	Studies|amod|START_ENTITY Studies|nmod|END_ENTITY	Role of cytochrome P450 1A2 in bilirubin degradation Studies in Cyp1a2 -LRB- - / - -RRB- mutant mice .
4029818	0	bilirubin	14,23	Fc_receptor	31,42	bilirubin	Fc receptor	MESH:D001663	109615(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|compound|END_ENTITY	The effect of bilirubin on the Fc_receptor expression and phagocytic activity of mouse peritoneal macrophages .
15245331	0	bilirubin	104,113	MRP1	50,54	bilirubin	MRP1	MESH:D001663	4363	Chemical	Gene	transport|nmod|START_ENTITY mediates|dobj|transport mediates|nsubj|END_ENTITY	The human multidrug-resistance-associated protein MRP1 mediates ATP-dependent transport of unconjugated bilirubin .
18713069	0	bilirubin	37,46	MRP1	124,128	bilirubin	MRP1	MESH:D001663	4363	Chemical	Gene	effect|nmod|START_ENTITY modulated|nsubjpass|effect modulated|nmod|level level|nmod|END_ENTITY	The cytotoxic effect of unconjugated bilirubin in human neuroblastoma SH-SY5Y cells is modulated by the expression level of MRP1 but not MDR1 .
14623264	0	bilirubin	98,107	Mrp1	63,67	bilirubin	Mrp1	MESH:D001663	24565(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	Upregulation in the expression of multidrug resistance protein Mrp1 mRNA and protein by increased bilirubin production in rat .
21297965	0	bilirubin	46,55	Mrp1	14,18	bilirubin	Mrp1	MESH:D001663	24565(Tax:10116)	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|END_ENTITY	Modulation of Mrp1 -LRB- ABCc1 -RRB- and Pgp -LRB- ABCb1 -RRB- by bilirubin at the blood-CSF and blood-brain barriers in the Gunn rat .
11134001	0	bilirubin	18,27	SLC21A6	86,93	bilirubin	SLC21A6	MESH:D001663	10599	Chemical	Gene	uptake|nmod|START_ENTITY uptake|nmod|END_ENTITY	Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6 .
21030469	0	bilirubin	20,29	UDP-glucuronosyltransferase_1A1	101,132	bilirubin	UDP-glucuronosyltransferase 1A1	MESH:D001663	54658	Chemical	Gene	START_ENTITY|nmod|presence presence|nmod|END_ENTITY	Correlation between bilirubin glucuronidation and estradiol-3-gluronidation in the presence of model UDP-glucuronosyltransferase_1A1 substrates/inhibitors .
22749334	0	bilirubin	78,87	UGT1A1	50,56	bilirubin	UGT1A1	MESH:D001663	54658	Chemical	Gene	levels|compound|START_ENTITY Effects|nmod|levels Effects|nmod|END_ENTITY	Effects of statin treatments and polymorphisms in UGT1A1 and SLCO1B1 on serum bilirubin levels in Chinese patients with hypercholesterolaemia .
13994	0	bilirubin	59,68	albumin	30,37	bilirubin	albumin	MESH:D001663	213	Chemical	Gene	Photooxidation|nmod|START_ENTITY Photooxidation|nmod|END_ENTITY	Photooxidation of human serum albumin and its complex with bilirubin .
8490056	0	bilirubin	9,18	albumin	42,49	bilirubin	albumin	MESH:D001663	213	Chemical	Gene	START_ENTITY|xcomp|binding binding|nmod|END_ENTITY	Abnormal bilirubin binding to human serum albumin in a patient with unusual_myeloma immunoglobulin G .
90526	0	bilirubin	11,20	alpha-fetoprotein	41,58	bilirubin	alpha-fetoprotein	MESH:D001663	174	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of bilirubin by bovine and human alpha-fetoprotein .
14458319	0	bilirubin	50,59	antithrombin	4,16	bilirubin	antithrombin	MESH:D001663	462	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	The antithrombin activity of glucuronic esters of bilirubin .
19036700	0	bilirubin	168,177	decay-accelerating_factor	120,145	bilirubin	decay-accelerating factor	MESH:D001663	1604	Chemical	Gene	role|nmod|START_ENTITY induction|dep|role induction|nmod|END_ENTITY	Heme_oxygenase-1 expression enhances vascular endothelial resistance to complement-mediated injury through induction of decay-accelerating_factor : a role for increased bilirubin and ferritin .
21700833	0	bilirubin	6,15	familial_hypercholesterolemia	26,55	bilirubin	familial hypercholesterolemia	MESH:D001663	3949	Chemical	Gene	levels|compound|START_ENTITY levels|nmod|END_ENTITY	Serum bilirubin levels in familial_hypercholesterolemia : a new risk marker for cardiovascular_disease ?
15724035	0	bilirubin	9,18	glucose-6-phosphate_dehydrogenase	63,96	bilirubin	glucose-6-phosphate dehydrogenase	MESH:D001663	2539	Chemical	Gene	imbalance|compound|START_ENTITY imbalance|dep|effect effect|nmod|deficiency deficiency|amod|END_ENTITY	Neonatal bilirubin production-conjugation imbalance : effect of glucose-6-phosphate_dehydrogenase deficiency and borderline prematurity .
8627445	0	bilirubin	11,20	glucose-6-phosphate_dehydrogenase	38,71	bilirubin	glucose-6-phosphate dehydrogenase	MESH:D001663	2539	Chemical	Gene	START_ENTITY|nmod|deficiency deficiency|amod|END_ENTITY	Conjugated bilirubin in neonates with glucose-6-phosphate_dehydrogenase deficiency .
24967753	0	bilirubin	98,107	glucose_dehydrogenase	76,97	bilirubin	glucose dehydrogenase	MESH:D001663	9563	Chemical	Gene	oxidase|compound|START_ENTITY oxidase|amod|END_ENTITY	Biofuel cells based on direct enzyme-electrode contacts using PQQ-dependent glucose_dehydrogenase / bilirubin oxidase and modified carbon nanotube materials .
6873615	0	bilirubin	31,40	mucin	19,24	bilirubin	mucin	MESH:D001663	404104(Tax:9913)	Chemical	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Bovine gallbladder mucin binds bilirubin in vitro .
9355767	0	bilirubin_glucuronides	27,49	MRP1	86,90	bilirubin glucuronides	MRP1	null	4363	Chemical	Gene	transport|nmod|START_ENTITY transport|nmod|END_ENTITY	ATP-dependent transport of bilirubin_glucuronides by the multidrug_resistance_protein MRP1 and its hepatocyte canalicular isoform MRP2 .
22042868	0	biliverdin	115,125	Toll-like_receptor-4	20,40	biliverdin	Toll-like receptor-4	MESH:D001664	21898(Tax:10090)	Chemical	Gene	reductase|compound|START_ENTITY translocation|nmod|reductase inhibits|nmod|translocation inhibits|dobj|expression expression|amod|END_ENTITY	Biliverdin inhibits Toll-like_receptor-4 -LRB- TLR4 -RRB- expression through nitric_oxide-dependent nuclear translocation of biliverdin reductase .
16258077	0	bilobalide	17,27	CYP2B1	70,76	bilobalide	CYP2B1	MESH:C073710	24300(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|modulation modulation|nmod|END_ENTITY	Distinct role of bilobalide and ginkgolide_A in the modulation of rat CYP2B1 and CYP3A23 gene expression by Ginkgo_biloba extract in cultured hepatocytes .
11958534	0	bilobalide	35,45	NADH_dehydrogenase	55,73	bilobalide	NADH dehydrogenase	MESH:C073710	26193(Tax:10116)	Chemical	Gene	level|amod|START_ENTITY level|compound|END_ENTITY	Ginkgo_biloba extracts EGb_761 and bilobalide increase NADH_dehydrogenase mRNA level and mitochondrial respiratory control ratio in PC12 cells .
21391918	0	bilobalide	26,36	platelet-activating_factor_receptor	95,130	bilobalide	platelet-activating factor receptor	MESH:C073710	58949(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Anti-ischaemic effects of bilobalide on neonatal rat cardiomyocytes and the involvement of the platelet-activating_factor_receptor .
20307962	0	binaphthyl_diselenide	52,73	catalase	15,23	binaphthyl diselenide	catalase	MESH:C551844	24248(Tax:10116)	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of catalase in the protective effect of binaphthyl_diselenide against renal_damage induced by glycerol .
17531571	0	binodenoson	34,45	adenosine_A2A_receptor	59,81	binodenoson	adenosine A2A receptor	MESH:C101949	135	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Coronary circulation responses to binodenoson , a selective adenosine_A2A_receptor agonist .
19920048	0	binodenoson	10,21	adenosine_A2A_receptor	35,57	binodenoson	adenosine A2A receptor	MESH:C101949	135	Chemical	Gene	Safety|nmod|START_ENTITY Safety|appos|vasodilator vasodilator|amod|END_ENTITY	Safety of binodenoson , a selective adenosine_A2A_receptor agonist vasodilator pharmacological stress agent , in healthy subjects with mild intermittent asthma .
17341609	0	bioamine	11,19	5-HT2B	34,40	bioamine	5-HT2B	null	3357	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|nmod|END_ENTITY	Control of bioamine metabolism by 5-HT2B and alpha 1D autoreceptors through reactive oxygen species and tumor_necrosis_factor-alpha signaling in neuronal cells .
23948065	0	biochanin_A	27,38	MLK3	0,4	biochanin A	MLK3	MESH:C004541	4296	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	MLK3 is a direct target of biochanin_A , which plays a role in solar UV-induced COX-2 expression in human keratinocytes .
16903077	0	biochanin_A	10,21	aryl_hydrocarbon_receptor	29,54	biochanin A	aryl hydrocarbon receptor	MESH:C004541	196	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of biochanin_A on the aryl_hydrocarbon_receptor and cytochrome_P450_1A1 in MCF-7 human breast_carcinoma cells .
9622078	0	biochanin_A	101,112	prostate_specific_antigen	61,86	biochanin A	prostate specific antigen	MESH:C004541	354	Chemical	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	Increased UDP-glucuronosyltransferase activity and decreased prostate_specific_antigen production by biochanin_A in prostate_cancer cells .
25593725	0	biochanin_a	10,21	visfatin	31,39	biochanin a	visfatin	MESH:C004541	297508(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|level level|compound|END_ENTITY	Effect of biochanin_a on serum visfatin level of streptozocin-induced diabetic rats .
18240292	0	bioflavonoid_apigenin	69,90	HIF-1_alpha	14,25	bioflavonoid apigenin	HIF-1 alpha	null	3091	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Inhibition of HIF-1_alpha and VEGF expression by the chemopreventive bioflavonoid_apigenin is accompanied by Akt inhibition in human prostate_carcinoma PC3-M cells .
1763650	0	bioflavonoid_silymarin	14,36	SOD	102,105	bioflavonoid silymarin	SOD	null	6647	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of the bioflavonoid_silymarin on the in vitro activity and expression of superoxide_dismutase -LRB- SOD -RRB- enzyme .
2788491	0	biopterins	23,33	Interleukin-2	0,13	biopterins	Interleukin-2	CHEBI:22881	3558	Chemical	Gene	enhances|dobj|START_ENTITY enhances|nsubj|END_ENTITY	Interleukin-2 enhances biopterins and catecholamines production during adoptive immunotherapy for various cancers .
19915929	0	biotin	10,16	C1q	34,37	biotin	C1q	MESH:D001710	712	Chemical	Gene	complexes|compound|START_ENTITY complexes|compound|END_ENTITY	Aptamer biotin streptavidin C1q complexes can trigger the classical complement pathway to kill cancer cells .
17904341	0	biotin	51,57	Holocarboxylase_synthetase	0,26	biotin	Holocarboxylase synthetase	MESH:D001710	3141	Chemical	Gene	transporters|compound|START_ENTITY expression|nmod|transporters regulates|dobj|expression regulates|nsubj|END_ENTITY	Holocarboxylase_synthetase regulates expression of biotin transporters by chromatin remodeling events at the SMVT locus .
555586	0	biotin	95,101	Pyruvate_carboxylase	0,20	biotin	Pyruvate carboxylase	MESH:D001710	5091	Chemical	Gene	status|compound|START_ENTITY activities|nmod|status activities|amod|END_ENTITY	Pyruvate_carboxylase activities in red blood cells and liver of chicks and their dependency on biotin status .
15623830	0	biotin	61,67	SLC19A3	40,47	biotin	SLC19A3	MESH:D001710	80704	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|appos|transporter	Biotin_deficiency reduces expression of SLC19A3 , a potential biotin transporter , in leukocytes from human blood .
18814980	0	biotin	15,21	biotinidase	64,75	biotin	biotinidase	MESH:D001710	306262(Tax:10116)	Chemical	Gene	supplementation|compound|START_ENTITY effects|nmod|supplementation END_ENTITY|nsubj|effects	The effects of biotin supplementation on serum and liver tissue biotinidase enzyme activity and alopecia in rats which were administrated to valproic_acid .
2123084	0	biotin	72,78	biotinidase	26,37	biotin	biotinidase	MESH:D001710	306262(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Association of pancreatic biotinidase activity and intestinal uptake of biotin and biocytin in hamster and rat .
10416947	0	biotin	10,16	glucokinase	32,43	biotin	glucokinase	MESH:D001710	2645	Chemical	Gene	START_ENTITY|appos|inducer inducer|nmod|expression expression|amod|END_ENTITY	High-dose biotin , an inducer of glucokinase expression , may synergize with chromium_picolinate to enable a definitive nutritional therapy for type_II_diabetes .
2037560	0	biotin	54,60	glucokinase	34,45	biotin	glucokinase	MESH:D001710	24385(Tax:10116)	Chemical	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Transcriptional regulation of the glucokinase gene by biotin in starved rats .
8870819	0	biotin	10,16	glucokinase	20,31	biotin	glucokinase	MESH:D001710	2645	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effect of biotin on glucokinase activity , mRNA expression and insulin release in cultured beta-cells .
16790503	0	biotin	96,102	hTHTR2	126,132	biotin	hTHTR2	MESH:D001710	80704	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Biotin-responsive_basal_ganglia_disease-linked mutations inhibit thiamine transport via hTHTR2 : biotin is not a substrate for hTHTR2 .
10590022	0	biotin	104,110	holocarboxylase_synthetase	114,140	biotin	holocarboxylase synthetase	MESH:D001710	3141	Chemical	Gene	START_ENTITY|nmod|deficiency deficiency|amod|END_ENTITY	Relationship between kinetic properties of mutant enzyme and biochemical and clinical responsiveness to biotin in holocarboxylase_synthetase deficiency .
12855220	0	biotin	20,26	holocarboxylase_synthetase	53,79	biotin	holocarboxylase synthetase	MESH:D001710	3141	Chemical	Gene	START_ENTITY|nmod|patient patient|nmod|deficiency deficiency|amod|END_ENTITY	Partial response to biotin therapy in a patient with holocarboxylase_synthetase deficiency : clinical , biochemical , and molecular genetic aspects .
19201116	0	biotin	87,93	holocarboxylase_synthetase	10,36	biotin	holocarboxylase synthetase	MESH:D001710	3141	Chemical	Gene	therapy|compound|START_ENTITY case|nmod|therapy case|nmod|deficiency deficiency|amod|END_ENTITY	A case of holocarboxylase_synthetase deficiency with insufficient response to prenatal biotin therapy .
19914215	0	biotin	78,84	holocarboxylase_synthetase	47,73	biotin	holocarboxylase synthetase	MESH:D001710	3141	Chemical	Gene	ligation|compound|START_ENTITY characteristics|nmod|ligation characteristics|nmod|END_ENTITY	Substrate recognition characteristics of human holocarboxylase_synthetase for biotin ligation .
7753853	0	biotin	97,103	holocarboxylase_synthetase	35,61	biotin	holocarboxylase synthetase	MESH:D001710	3141	Chemical	Gene	auxotroph|compound|START_ENTITY complementation|nmod|auxotroph encoding|nmod|complementation encoding|dobj|END_ENTITY	Isolation of a cDNA encoding human holocarboxylase_synthetase by functional complementation of a biotin auxotroph of Escherichia_coli .
9396568	0	biotin	70,76	holocarboxylase_synthetase	27,53	biotin	holocarboxylase synthetase	MESH:D001710	3141	Chemical	Gene	Km|nmod|START_ENTITY END_ENTITY|dep|Km	Characterization of mutant holocarboxylase_synthetase -LRB- HCS -RRB- : a Km for biotin was not elevated in a patient with HCS_deficiency .
10858297	0	biotin	58,64	pyruvate_carboxylase	91,111	biotin	pyruvate carboxylase	MESH:D001710	5091	Chemical	Gene	reaction|amod|START_ENTITY reaction|nmod|END_ENTITY	Effects of Mg -LRB- 2 + -RRB- on the pre-steady-state kinetics of the biotin carboxylation reaction of pyruvate_carboxylase .
2065895	0	biotin	42,48	pyruvate_carboxylase	10,30	biotin	pyruvate carboxylase	MESH:D001710	5091	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|dep|effect	Mammalian pyruvate_carboxylase : effect of biotin on the synthesis and translocation of apo-enzyme into 3T3-L adipocyte mitochondria .
23098296	0	biotin	45,51	pyruvate_carboxylase	68,88	biotin	pyruvate carboxylase	MESH:D001710	5091	Chemical	Gene	domain|compound|START_ENTITY Localization|nmod|domain Localization|nmod|END_ENTITY	Localization of inhibitory antibodies to the biotin domain of human pyruvate_carboxylase .
23698000	0	biotin	20,26	pyruvate_carboxylase	79,99	biotin	pyruvate carboxylase	MESH:D001710	5091	Chemical	Gene	pocket|compound|START_ENTITY pocket|nmod|domain domain|nmod|END_ENTITY	A substrate-induced biotin binding pocket in the carboxyltransferase domain of pyruvate_carboxylase .
3101494	0	biotin	94,100	pyruvate_carboxylase	44,64	biotin	pyruvate carboxylase	MESH:D001710	5091	Chemical	Gene	correlation|nmod|START_ENTITY deficiency|appos|correlation deficiency|amod|END_ENTITY	The French and North American phenotypes of pyruvate_carboxylase deficiency , correlation with biotin containing protein by 3H-biotin incorporation , 35S-streptavidin labeling , and Northern blotting with a cloned cDNA probe .
638124	0	biotin	67,73	pyruvate_carboxylase	6,26	biotin	pyruvate carboxylase	MESH:D001710	374263(Tax:9031)	Chemical	Gene	status|compound|START_ENTITY criterion|nmod|status activity|nmod|criterion activity|amod|END_ENTITY	Blood pyruvate_carboxylase -LRB- EC 6.4.1.1 -RRB- activity as a criterion of biotin status in chickens and turkeys .
7104292	0	biotin	51,57	pyruvate_carboxylase	123,143	biotin	pyruvate carboxylase	MESH:D001710	5091	Chemical	Gene	determination|nmod|START_ENTITY determination|nmod|activity activity|amod|bioassay bioassay|advcl|response response|nmod|END_ENTITY	The determination of the availability to chicks of biotin in feed ingredients by a bioassay based on the response of blood pyruvate_carboxylase -LRB- EC 6.4.1.1 -RRB- activity .
7455346	0	biotin	54,60	pyruvate_carboxylase	6,26	biotin	pyruvate carboxylase	MESH:D001710	397630(Tax:9823)	Chemical	Gene	status|compound|START_ENTITY criterion|nmod|status END_ENTITY|nmod|criterion	Blood pyruvate_carboxylase activity as a criterion of biotin status in young pigs .
844949	0	biotin	17,23	pyruvate_carboxylase	52,72	biotin	pyruvate carboxylase	MESH:D001710	374263(Tax:9031)	Chemical	Gene	levels|compound|START_ENTITY Effect|nmod|levels Effect|nmod|diet diet|nmod|END_ENTITY	Effect of graded biotin levels in the diet on liver pyruvate_carboxylase of chicks fed ad libitum and after starvation .
8620009	0	biotin	62,68	pyruvate_carboxylase	95,115	biotin	pyruvate carboxylase	MESH:D001710	5091	Chemical	Gene	reaction|compound|START_ENTITY kinetics|nmod|reaction Effects|nmod|kinetics Effects|nmod|END_ENTITY	Effects of acetyl_CoA on the pre-steady-state kinetics of the biotin carboxylation reaction of pyruvate_carboxylase .
3255355	0	biotinyl-peptides	17,34	biotinidase	38,49	biotinyl-peptides	biotinidase	null	686	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	Effect of plasma biotinyl-peptides on biotinidase activity .
21224499	0	biphenol-A-diglicydyl_ether	114,141	peroxisome_proliferator-activated_receptor_gamma	17,65	biphenol-A-diglicydyl ether	peroxisome proliferator-activated receptor gamma	null	25664(Tax:10116)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of the peroxisome_proliferator-activated_receptor_gamma -LRB- PPAR-y -RRB- agonist , rosiglitazone and antagonist , biphenol-A-diglicydyl_ether -LRB- BADGE -RRB- on the course of inflammation in the experimental model of colitis in rats .
16713264	0	biphenyl	69,77	histamine_H3_receptor	22,43	biphenyl	histamine H3 receptor	MESH:C010574	11255	Chemical	Gene	antagonists|nmod|START_ENTITY antagonists|amod|END_ENTITY	Dibasic non-imidazole histamine_H3_receptor antagonists with a rigid biphenyl scaffold .
16839761	0	biphenyl_carboxamide	7,27	melanin-concentrating_hormone_receptor_1	49,89	biphenyl carboxamide	melanin-concentrating hormone receptor 1	null	2847	Chemical	Gene	ligands|amod|START_ENTITY ligands|nmod|END_ENTITY	SAR of biphenyl_carboxamide ligands of the human melanin-concentrating_hormone_receptor_1 -LRB- MCH_R1 -RRB- : discovery of antagonist SB-568849 .
7798964	0	biphenyl_ether	20,34	5-lipoxygenase	40,54	biphenyl ether	5-lipoxygenase	null	240	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Cylindol_A , a novel biphenyl_ether with 5-lipoxygenase inhibitory activity , and a related compound from Imperata Cylindrica .
16824509	0	biphenylacetic_acid	86,105	interleukin-1beta	17,34	biphenylacetic acid	interleukin-1beta	MESH:C012776	24494(Tax:10116)	Chemical	Gene	Changes|nmod|START_ENTITY Changes|nmod|END_ENTITY	Changes in brain interleukin-1beta following the coadministration of norfloxacin with biphenylacetic_acid in rats .
20550118	0	biphenylmethylene_4-pyridine	66,94	CYP17	100,105	biphenylmethylene 4-pyridine	CYP17	null	1586	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Isopropylidene substitution increases activity and selectivity of biphenylmethylene_4-pyridine type CYP17 inhibitors .
16275085	0	biphenylsulfonamide_carboxylate	39,70	aggrecanase-1	71,84	biphenylsulfonamide carboxylate	aggrecanase-1	null	66015(Tax:10116)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Synthesis and biological evaluation of biphenylsulfonamide_carboxylate aggrecanase-1 inhibitors .
18805008	0	bis-amides	64,74	GlyT1	99,104	bis-amides	GlyT1	null	6536	Chemical	Gene	relationship|nmod|START_ENTITY relationship|nmod|END_ENTITY	Design , synthesis and structure-activity relationship of simple bis-amides as potent inhibitors of GlyT1 .
26545798	0	bis-aryl_urea	13,26	Limk	63,67	bis-aryl urea	Limk	null	3984	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|inhibitors inhibitors|compound|END_ENTITY	Discovery of bis-aryl_urea derivatives as potent and selective Limk inhibitors : Exploring Limk1 activity and Limk1/ROCK2 selectivity through a combined computational study .
22424148	0	bis-benzimidazoles	37,55	dihydrofolate_reductase	123,146	bis-benzimidazoles	dihydrofolate reductase	null	1719	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Fragment-based design of symmetrical bis-benzimidazoles as selective inhibitors of the trimethoprim-resistant , type II R67 dihydrofolate_reductase .
21821416	0	bis-benzimidazoles	82,100	helicase	18,26	bis-benzimidazoles	helicase	null	164045	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activity activity|amod|END_ENTITY	Inhibition of the helicase activity of the HCV NS3 protein by symmetrical dimeric bis-benzimidazoles .
11249115	0	bis-catechols	4,17	5-lipoxygenase	18,32	bis-catechols	5-lipoxygenase	null	240	Chemical	Gene	START_ENTITY|dobj|inhibitors inhibitors|amod|END_ENTITY	New bis-catechols 5-lipoxygenase inhibitors .
1339155	0	bis-chloroethylnitrosourea	93,119	O6-methylguanine-DNA_methyltransferase	0,38	bis-chloroethylnitrosourea	O6-methylguanine-DNA methyltransferase	null	4255	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	O6-methylguanine-DNA_methyltransferase activity and sensitivity of human tumor cell lines to bis-chloroethylnitrosourea .
6318769	0	bis-chloronitrosourea	11,32	angiotensin_converting_enzyme	63,92	bis-chloronitrosourea	angiotensin converting enzyme	null	24310(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|compound|END_ENTITY	Effects of bis-chloronitrosourea -LRB- BCNU -RRB- on pulmonary and serum angiotensin_converting_enzyme activity in rats .
3922786	0	bis-p-nitrophenyl_methylphosphonate	48,83	pancreatic_lipase	27,44	bis-p-nitrophenyl methylphosphonate	pancreatic lipase	null	5406	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Irreversible inhibition of pancreatic_lipase by bis-p-nitrophenyl_methylphosphonate .
8798583	0	bis-tetrahydroaminacrine	39,63	acetylcholinesterase	78,98	bis-tetrahydroaminacrine	acetylcholinesterase	null	83817(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|inhibitors inhibitors|nmod|END_ENTITY	Highly potent , selective , and low cost bis-tetrahydroaminacrine inhibitors of acetylcholinesterase .
23141909	0	bis-thiazolone	30,44	CDC25	71,76	bis-thiazolone	CDC25	null	995	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|inhibitors inhibitors|compound|END_ENTITY	Design and synthesis of novel bis-thiazolone derivatives as micromolar CDC25 phosphatase inhibitors : effect of dimerisation on phosphatase inhibition .
16644218	0	bis-trifluoromethyl_carbinols	23,52	malonyl-CoA_decarboxylase	56,81	bis-trifluoromethyl carbinols	malonyl-CoA decarboxylase	null	85239(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Heteroaryl substituted bis-trifluoromethyl_carbinols as malonyl-CoA_decarboxylase inhibitors .
15710623	0	bis7-tacrine	45,57	acetylcholinesterase	14,34	bis7-tacrine	acetylcholinesterase	MESH:C122128	83817(Tax:10116)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	Novel dimeric acetylcholinesterase inhibitor bis7-tacrine , but not donepezil , prevents glutamate-induced neuronal_apoptosis by blocking N-methyl-D-aspartate receptors .
25194056	0	bisacycloxypropylcysteine	10,35	TLR6	72,76	bisacycloxypropylcysteine	TLR6	null	21899(Tax:10090)	Chemical	Gene	START_ENTITY|appos|ligand ligand|nmod|END_ENTITY	Pegylated bisacycloxypropylcysteine , a diacylated lipopeptide ligand of TLR6 , plays a host-protective role against experimental Leishmania_major infection .
26036131	0	bisamidinohydrazones	54,74	furin	104,109	bisamidinohydrazones	furin	null	5045	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Synthesis , biological evaluation and docking of novel bisamidinohydrazones as non-peptide inhibitors of furin .
19928766	0	bisaryl_substituted_thiazoles	6,35	peroxisome_proliferator-activated_receptor_delta	80,128	bisaryl substituted thiazoles	peroxisome proliferator-activated receptor delta	null	19015(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|agonists agonists|amod|END_ENTITY	Novel bisaryl_substituted_thiazoles and oxazoles as highly potent and selective peroxisome_proliferator-activated_receptor_delta agonists .
11850431	1	bisdioxopiperazine	104,122	ATPase	64,70	bisdioxopiperazine	ATPase	null	1769	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activity activity|compound|END_ENTITY	Inhibition of ATPase activity by the anti-cancer drug bisdioxopiperazine and ATP/ADP-induced dimerization .
7922131	0	bishydroxamic_acids	6,25	5-lipoxygenase	29,43	bishydroxamic acids	5-lipoxygenase	null	25290(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Novel bishydroxamic_acids as 5-lipoxygenase inhibitors .
10828032	0	bisindolylmaleimide	117,136	c-FLIP	14,20	bisindolylmaleimide	c-FLIP	MESH:C088060	8837	Chemical	Gene	inhibition|nmod|START_ENTITY Expression|dep|inhibition Expression|nmod|END_ENTITY	Expression of c-FLIP -LRB- L -RRB- and resistance to CD95-mediated apoptosis of monocyte-derived dendritic cells : inhibition by bisindolylmaleimide .
26275866	0	bisindolylmethane	87,104	carbonic_anhydrase_II	108,129	bisindolylmethane	carbonic anhydrase II	null	760	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|amod|END_ENTITY	Synthesis , biological evaluation , and docking studies of novel thiourea derivatives of bisindolylmethane as carbonic_anhydrase_II inhibitor .
11110794	0	bismuth	23,30	transferrin	34,45	bismuth	transferrin	MESH:D001729	7018	Chemical	Gene	binding|nmod|START_ENTITY binding|nmod|END_ENTITY	Competitive binding of bismuth to transferrin and albumin in aqueous solution and in blood plasma .
3260885	0	bismuth_subcitrate	93,111	Epidermal_growth_factor	0,23	bismuth subcitrate	Epidermal growth factor	MESH:C002791	25313(Tax:10116)	Chemical	Gene	actions|nmod|START_ENTITY END_ENTITY|nmod|actions	Epidermal_growth_factor -LRB- EGF -RRB- in the gastroprotective and ulcer_healing actions of colloidal bismuth_subcitrate -LRB- De-Nol -RRB- in rats .
3171356	0	bismuth_subgallate	45,63	Hageman_factor	14,28	bismuth subgallate	Hageman factor	MESH:C002170	2161	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of Hageman_factor -LRB- factor XII -RRB- by bismuth_subgallate , a hemostatic agent .
10641051	0	bisnaphthoquinone	40,57	5alpha-reductase	13,29	bisnaphthoquinone	5alpha-reductase	null	6715	Chemical	Gene	START_ENTITY|nsubj|inhibitor inhibitor|amod|END_ENTITY	Testosterone 5alpha-reductase inhibitor bisnaphthoquinone derivative from Impatiens balsamina .
16988481	0	bisnorcymserine	112,127	butyrylcholinesterase	24,45	bisnorcymserine	butyrylcholinesterase	MESH:C517198	590	Chemical	Gene	START_ENTITY|nsubj|Kinetics Kinetics|nmod|END_ENTITY	Kinetics of human serum butyrylcholinesterase and its inhibition by a novel experimental Alzheimer therapeutic , bisnorcymserine .
2464104	0	bisoprolol	56,66	Beta_1-adrenoceptor	0,19	bisoprolol	Beta 1-adrenoceptor	MESH:D017298	153	Chemical	Gene	selectivity|nmod|START_ENTITY selectivity|amod|END_ENTITY	Beta_1-adrenoceptor selectivity of single oral doses of bisoprolol and atenolol .
22586283	0	bisoprolol	56,66	b-1	31,34	bisoprolol	b-1	MESH:D017298	28905	Chemical	Gene	blocker|appos|START_ENTITY blocker|amod|END_ENTITY	Efficacy and tolerability of a b-1 selective b blocker , bisoprolol , as a first-line antihypertensive in Indian patients diagnosed with essential hypertension -LRB- BRIGHT -RRB- : an open-label , multicentric observational study .
1676675	0	bisoprolol	72,82	beta_1-adrenoceptor	37,56	bisoprolol	beta 1-adrenoceptor	MESH:D017298	153	Chemical	Gene	selectivity|nmod|START_ENTITY selectivity|amod|END_ENTITY	A dose-ranging study to evaluate the beta_1-adrenoceptor selectivity of bisoprolol .
19068205	0	bisoprolol	12,22	interleukin-6	32,45	bisoprolol	interleukin-6	MESH:D017298	3569	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of bisoprolol on serum interleukin-6 and tumor_necrosis_factor-alpha level in patients with congestive_heart_failure -RSB- .
24166839	0	bisperoxovanadium	19,36	IGF-1	72,77	bisperoxovanadium	IGF-1	MESH:C472777	24482(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	The PTEN inhibitor bisperoxovanadium enhances myelination by amplifying IGF-1 signaling in rat and human oligodendrocyte progenitors .
25088689	0	bisphenol-A	116,127	EZH2	26,30	bisphenol-A	EZH2	MESH:C006780	312299(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Histone methyltransferase EZH2 is transcriptionally induced by estradiol as well as estrogenic endocrine disruptors bisphenol-A and diethylstilbestrol .
17574696	0	bisphenol_A	20,31	CA3	105,108	bisphenol A	CA3	MESH:C006780	54232(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|neurons neurons|compound|END_ENTITY	Multiple effects of bisphenol_A , an endocrine disrupter , on GABA -LRB- A -RRB- receptors in acutely dissociated rat CA3 pyramidal neurons .
21983029	0	bisphenol_A	20,31	CD-1	54,58	bisphenol A	CD-1	MESH:C006780	111334(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|compound|END_ENTITY	Pharmacokinetics of bisphenol_A in neonatal and adult CD-1 mice : inter-species comparisons with Sprague-Dawley_rats and rhesus_monkeys .
23425943	0	bisphenol_A	24,35	CD-1	77,81	bisphenol A	CD-1	MESH:C006780	111334(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|mice mice|compound|END_ENTITY	Effects of low doses of bisphenol_A on the metabolome of perinatally exposed CD-1 mice .
22327052	0	bisphenol_A	11,22	CYP19	71,76	bisphenol A	CYP19	MESH:C006780	1588	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of bisphenol_A on the expression of cytochrome_P450_aromatase -LRB- CYP19 -RRB- in human fetal osteoblastic and granulosa cell-like cell lines .
11061999	0	bisphenol_A	72,83	Cyp1a-1	26,33	bisphenol A	Cyp1a-1	MESH:C006780	13076(Tax:10090)	Chemical	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|nmod|END_ENTITY	Down-regulation of murine Cyp1a-1 in mouse hepatoma Hepa-1c1c7 cells by bisphenol_A .
20064783	0	bisphenol_A	58,69	IGF-1	99,104	bisphenol A	IGF-1	MESH:C006780	3479	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|acl|END_ENTITY	Peroxisome_proliferator-activated_receptor-gamma mediates bisphenol_A inhibition of FSH-stimulated IGF-1 , aromatase , and estradiol in human granulosa cells .
23719110	0	bisphenol_A	12,23	OCT4	27,31	bisphenol A	OCT4	MESH:C006780	100846986	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	-LSB- Effects of bisphenol_A on OCT4 and SOX2 genes expression in mouse embryonic stem cells -RSB- .
25122773	0	bisphenol_A	164,175	PDI	132,135	bisphenol A	PDI	MESH:C006780	64714	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of the functional interplay between endoplasmic reticulum -LRB- ER -RRB- oxidoreduclin-1a -LRB- Ero1a -RRB- and protein-disulfide_isomerase -LRB- PDI -RRB- by the endocrine disruptor bisphenol_A .
20064783	0	bisphenol_A	58,69	Peroxisome_proliferator-activated_receptor-gamma	0,48	bisphenol A	Peroxisome proliferator-activated receptor-gamma	MESH:C006780	5468	Chemical	Gene	inhibition|compound|START_ENTITY mediates|dobj|inhibition mediates|nsubj|END_ENTITY	Peroxisome_proliferator-activated_receptor-gamma mediates bisphenol_A inhibition of FSH-stimulated IGF-1 , aromatase , and estradiol in human granulosa cells .
14967906	0	bisphenol_A	32,43	RARalpha	61,69	bisphenol A	RARalpha	MESH:C006780	19401(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effects of in utero exposure to bisphenol_A on expression of RARalpha and RXRalpha mRNAs in murine embryos .
20499049	0	bisphenol_A	61,72	TNF-alpha	14,23	bisphenol A	TNF-alpha	MESH:C006780	7124	Chemical	Gene	treated|nmod|START_ENTITY cells|acl|treated Expression|nmod|cells Expression|nmod|END_ENTITY	Expression of TNF-alpha and IL-6 in HMC-1 cells treated with bisphenol_A is attenuated by plant-originating glycoprotein -LRB- 75 kDa -RRB- by blocking p38_MAPK .
11393178	0	bisphenol_A	28,39	VEGF	93,97	bisphenol A	VEGF	MESH:C006780	83785(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of the xenoestrogen bisphenol_A on expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in the rat .
22327052	0	bisphenol_A	11,22	cytochrome_P450_aromatase	44,69	bisphenol A	cytochrome P450 aromatase	MESH:C006780	1588	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effects of bisphenol_A on the expression of cytochrome_P450_aromatase -LRB- CYP19 -RRB- in human fetal osteoblastic and granulosa cell-like cell lines .
17049190	0	bisphenol_A	20,31	estrogen-related_receptor_gamma	56,87	bisphenol A	estrogen-related receptor gamma	MESH:C006780	2104	Chemical	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Endocrine disruptor bisphenol_A strongly binds to human estrogen-related_receptor_gamma -LRB- ERRgamma -RRB- with high constitutive activity .
16860915	0	bisphenol_A	10,21	glial_fibrillary_acidic_protein	46,77	bisphenol A	glial fibrillary acidic protein	MESH:C006780	14580(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|production production|nmod|END_ENTITY	Low-level bisphenol_A increases production of glial_fibrillary_acidic_protein in differentiating astrocyte progenitor cells through excessive STAT3 and Smad1 activation .
17928132	0	bisphenol_A	96,107	growth_hormone	70,84	bisphenol A	growth hormone	MESH:C006780	81668(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Over-expression of protein_disulfide_isomerase reduces the release of growth_hormone induced by bisphenol_A and/or T3 .
18729329	0	bisphenol_A	24,35	histone_H2AX	61,73	bisphenol A	histone H2AX	MESH:C006780	3014	Chemical	Gene	generates|nsubj|START_ENTITY generates|dobj|END_ENTITY	UVB-exposed chlorinated bisphenol_A generates phosphorylated histone_H2AX in human skin cells .
24512454	0	bisphenol_A	97,108	protein_disulfide_isomerase	60,87	bisphenol A	protein disulfide isomerase	MESH:C006780	25506(Tax:10116)	Chemical	Gene	_|nmod|START_ENTITY _|nmod|END_ENTITY	Endoplasmic_reticulum_protein _ -LRB- ERp -RRB- _ 29 binds as strongly as protein_disulfide_isomerase -LRB- PDI -RRB- to bisphenol_A .
22445847	0	bisphenol_A	63,74	tyrosinase	19,29	bisphenol A	tyrosinase	MESH:C006780	7299	Chemical	Gene	biosensor|nmod|START_ENTITY biosensor|compound|END_ENTITY	Nanographene-based tyrosinase biosensor for rapid detection of bisphenol_A .
11393178	0	bisphenol_A	28,39	vascular_endothelial_growth_factor	57,91	bisphenol A	vascular endothelial growth factor	MESH:C006780	83785(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effects of the xenoestrogen bisphenol_A on expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in the rat .
16284450	0	bisphenol_a	32,43	aryl_hydrocarbon_receptor	65,90	bisphenol a	aryl hydrocarbon receptor	MESH:C006780	11622(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of exposure in utero to bisphenol_a on the expression of aryl_hydrocarbon_receptor , related factors , and xenobiotic metabolizing enzymes in murine embryos .
21110804	0	bisphosphates	39,52	farnesyl_pyrophosphate_synthase	56,87	bisphosphates	farnesyl pyrophosphate synthase	null	2224	Chemical	Gene	binding|nmod|START_ENTITY binding|acl|END_ENTITY	Computational insights into binding of bisphosphates to farnesyl_pyrophosphate_synthase .
11211310	0	bisphosphonate	11,25	MMP-2	44,49	bisphosphonate	MMP-2	null	4313	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|release release|nmod|END_ENTITY	Effects of bisphosphonate on the release of MMP-2 from cultured human osteoblasts .
16979395	0	bisphosphonate	56,70	OPG	6,9	bisphosphonate	OPG	null	4982	Chemical	Gene	treatment|compound|START_ENTITY Serum|nmod|treatment Serum|dobj|levels levels|compound|END_ENTITY	Serum OPG and RANKL levels before and after intravenous bisphosphonate treatment in Paget 's _ disease_of_bone .
18208588	0	bisphosphonate	30,44	P-C-P	45,50	bisphosphonate	P-C-P	null	54858	Chemical	Gene	degradation|nmod|START_ENTITY END_ENTITY|nsubj|degradation	Unexpected degradation of the bisphosphonate P-C-P bridge under mild conditions .
22022584	0	bisphosphonate	27,41	Parathyroid_hormone	0,19	bisphosphonate	Parathyroid hormone	null	5741	Chemical	Gene	treatment|amod|START_ENTITY END_ENTITY|nmod|treatment	Parathyroid_hormone versus bisphosphonate treatment on bone mineral density in osteoporosis therapy : a meta-analysis of randomized controlled trials .
15670755	0	bisphosphonate	20,34	RANKL	87,92	bisphosphonate	RANKL	null	21943(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Nitrogen-containing bisphosphonate , YM529/ONO -5920 -LRB- a novel minodronic_acid -RRB- , inhibits RANKL expression in a cultured bone marrow stromal cell line ST2 .
3124942	0	bisphosphonate	31,45	acute-phase_response	4,24	bisphosphonate	acute-phase response	null	5366	Chemical	Gene	administration|amod|START_ENTITY END_ENTITY|nmod|administration	The acute-phase_response after bisphosphonate administration .
19454038	0	bisphosphonate	51,65	hormone_receptor	69,85	bisphosphonate	hormone receptor	null	3164	Chemical	Gene	START_ENTITY|nmod|patients patients|amod|END_ENTITY	Potential antitumor effects of nitrogen-containing bisphosphonate in hormone_receptor negative breast_cancer patients with bone metastases .
17979996	0	bisphosphonate	20,34	macrophage_inflammatory_protein_1_alpha	61,100	bisphosphonate	macrophage inflammatory protein 1 alpha	null	20302(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Nitrogen-containing bisphosphonate , YM529/ONO -5920 , inhibits macrophage_inflammatory_protein_1_alpha expression and secretion in mouse myeloma cells .
23688101	0	bisphosphonate	45,59	parathyroid_hormone	67,86	bisphosphonate	parathyroid hormone	null	24694(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|therapy therapy|amod|END_ENTITY	Distinctive tooth-extraction socket healing : bisphosphonate versus parathyroid_hormone therapy .
24558532	0	bisphosphonates	66,81	CTX	127,130	bisphosphonates	CTX	MESH:D004164	1593	Chemical	Gene	treated|nmod|START_ENTITY treated|nmod|END_ENTITY	Bone necrosis around dental implants : A patient treated with oral bisphosphonates , drug holiday and no risk according to serum CTX .
26856585	0	bisphosphonates	93,108	DKK1	122,126	bisphosphonates	DKK1	MESH:D004164	22943	Chemical	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Impaired_bone_remodeling in children with osteogenesis_imperfecta treated and untreated with bisphosphonates : the role of DKK1 , RANKL , and TNF-a .
16515701	0	bisphosphonates	14,29	GAPDH	50,55	bisphosphonates	GAPDH	MESH:D004164	2597	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|END_ENTITY	The effect of bisphosphonates on gene expression : GAPDH as a housekeeping or a new target gene ?
17374166	0	bisphosphonates	83,98	Interleukin-6	4,17	bisphosphonates	Interleukin-6	MESH:D004164	3569	Chemical	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	The Interleukin-6 inflammation pathway from cholesterol to aging -- role of statins , bisphosphonates and plant polyphenols in aging and age-related diseases .
19903468	0	bisphosphonates	33,48	Protein_kinase_C	0,16	bisphosphonates	Protein kinase C	MESH:D004164	112476	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|END_ENTITY	Protein_kinase_C is inhibited by bisphosphonates in prostate_cancer PC-3 cells .
12085990	0	bisphosphonates	21,36	RANKL	91,96	bisphosphonates	RANKL	MESH:D004164	21943(Tax:10090)	Chemical	Gene	action|nmod|START_ENTITY involve|nsubj|action involve|dobj|regulation regulation|nmod|expression expression|compound|END_ENTITY	Inhibitory action of bisphosphonates on bone resorption does not involve the regulation of RANKL and OPG expression .
15845617	0	bisphosphonates	102,117	RANKL	18,23	bisphosphonates	RANKL	MESH:D004164	21943(Tax:10090)	Chemical	Gene	causes|advcl|START_ENTITY causes|nsubj|inhibition inhibition|nmod|END_ENTITY	The inhibition of RANKL causes greater suppression of bone resorption and hypercalcemia compared with bisphosphonates in two models of humoral_hypercalcemia_of_malignancy .
16393773	0	bisphosphonates	25,40	RANKL	67,72	bisphosphonates	RANKL	MESH:D004164	8600	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	The inhibitory effect of bisphosphonates on glucocorticoid-induced RANKL expression in human cells .
20701670	0	bisphosphonates	10,25	RANKL	102,107	bisphosphonates	RANKL	MESH:D004164	8600	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|END_ENTITY	Effect of bisphosphonates on human gingival fibroblast production of mediators of osteoclastogenesis : RANKL , osteoprotegerin and interleukin-6 .
24490900	0	bisphosphonates	20,35	RANKL	44,49	bisphosphonates	RANKL	MESH:D004164	21943(Tax:10090)	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|formation formation|amod|END_ENTITY	Nitrogen-containing bisphosphonates inhibit RANKL - and M-CSF-induced osteoclast formation through the inhibition of ERK1/2 and Akt activation .
9051721	0	bisphosphonates	11,26	alkaline_phosphatase	30,50	bisphosphonates	alkaline phosphatase	MESH:D004164	250	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effects of bisphosphonates on alkaline_phosphatase activity , mineralization , and prostaglandin_E2 synthesis in the clonal osteoblast-like cell line MC3T3-E1 .
9443074	0	bisphosphonates	23,38	alkaline_phosphatase	65,85	bisphosphonates	alkaline phosphatase	MESH:D004164	250	Chemical	Gene	exert|nsubj|START_ENTITY exert|nmod|END_ENTITY	Structurally different bisphosphonates exert opposing effects on alkaline_phosphatase and mineralization in marrow osteoprogenitors .
12005179	0	bisphosphonates	22,37	basic_fibroblast_growth_factor	52,82	bisphosphonates	basic fibroblast growth factor	MESH:D004164	2247	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of intravenous bisphosphonates on release of basic_fibroblast_growth_factor in serum of patients with cancer-associated hypercalcemia .
21420384	0	bisphosphonates	145,160	farnesyl_pyrophosphate_synthase	55,86	bisphosphonates	farnesyl pyrophosphate synthase	MESH:D004164	2224	Chemical	Gene	pathway|nmod|START_ENTITY Correlation|nmod|pathway Correlation|nmod|END_ENTITY	Correlation between time-dependent inhibition of human farnesyl_pyrophosphate_synthase and blockade of mevalonate pathway by nitrogen-containing bisphosphonates in cultured cells .
26318908	0	bisphosphonates	79,94	farnesyl_pyrophosphate_synthase	24,55	bisphosphonates	farnesyl pyrophosphate synthase	MESH:D004164	2224	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	The inhibition of human farnesyl_pyrophosphate_synthase by nitrogen-containing bisphosphonates .
21824331	0	bisquinazoline_glycosides	42,67	epidermal_growth_factor_receptor	71,103	bisquinazoline glycosides	epidermal growth factor receptor	null	1956	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Design and synthesis of a series of novel bisquinazoline_glycosides as epidermal_growth_factor_receptor inhibitors .
8651926	0	bistratene_A	14,26	protein_kinase_C-delta	37,59	bistratene A	protein kinase C-delta	MESH:C059975	5580	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	The polyether bistratene_A activates protein_kinase_C-delta and induces growth_arrest in HL60 cells .
4424068	0	bisulfite	20,29	P582	41,45	bisulfite	P582	MESH:C042345	3803	Chemical	Gene	reductase|amod|START_ENTITY reductase|appos|END_ENTITY	Observations on the bisulfite reductase -LRB- P582 -RRB- isolated from Desulfotomaculum nigrificans .
23132267	0	bitopertin	40,50	Glycine_transporter_type_1	0,26	bitopertin	Glycine transporter type 1	MESH:C550631	6536	Chemical	Gene	occupancy|nmod|START_ENTITY occupancy|amod|END_ENTITY	Glycine_transporter_type_1 occupancy by bitopertin : a positron emission tomography study in healthy volunteers .
16079449	0	bivalirudin	92,103	thrombin	51,59	bivalirudin	thrombin	MESH:C074619	2147	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|report report|nmod|END_ENTITY	A safety and feasibility report of combined direct thrombin and GP_IIb / IIIa inhibition with bivalirudin and tirofiban in peripheral vascular disease intervention : treating critical_limb_ischemia like acute_coronary_syndrome .
22578460	0	blapsins_A_and_B	18,34	14-3-3	60,66	blapsins A and B	14-3-3	null	10971	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Identification of blapsins_A_and_B as potent small-molecule 14-3-3 inhibitors from the insect Blaps japanensis .
15205456	0	blebbistatin	13,25	myosin	40,46	blebbistatin	myosin	MESH:C472645	79784	Chemical	Gene	inhibition|compound|START_ENTITY Mechanism|nmod|inhibition Mechanism|nmod|II II|compound|END_ENTITY	Mechanism of blebbistatin inhibition of myosin II .
15544354	0	blebbistatin	21,33	myosin	58,64	blebbistatin	myosin	MESH:C472645	79784	Chemical	Gene	inhibition|compound|START_ENTITY mechanism|nmod|inhibition mechanism|nmod|IIb IIb|compound|END_ENTITY	Kinetic mechanism of blebbistatin inhibition of nonmuscle myosin IIb .
15548862	0	blebbistatin	15,27	myosin	45,51	blebbistatin	myosin	MESH:C472645	79784	Chemical	Gene	Specificity|nmod|START_ENTITY Specificity|appos|inhibitor inhibitor|nmod|II II|compound|END_ENTITY	Specificity of blebbistatin , an inhibitor of myosin II .
15671182	7	blebbistatin	1494,1506	myosin	1466,1472	blebbistatin	myosin	MESH:C472645	79784	Chemical	Gene	inhibited|nmod|START_ENTITY END_ENTITY|acl:relcl|inhibited	Our results are consistent with myosin II being the only Dictyostelium myosin that is inhibited by blebbistatin but also show that blebbistatin-inactivated myosin II inhibits some myosin II-independent processes and that blebbistatin inhibits other activities in the absence of myosin II .
15854904	9	blebbistatin	1230,1242	myosin	1084,1090	blebbistatin	myosin	MESH:C472645	79784	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|advcl|test test|dobj|role role|nmod|II II|compound|END_ENTITY	To test the role of myosin II in actin turnover and transport during CR formation , we inhibited myosin light-chain kinase with ML7 and myosin II ATPase activity with blebbistatin .
17132816	0	blebbistatin	101,113	myosin	80,86	blebbistatin	myosin	MESH:C472645	79784	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Potent inhibition of arterial smooth muscle tonic contractions by the selective myosin II inhibitor , blebbistatin .
19413972	0	blebbistatin	57,69	myosin	128,134	blebbistatin	myosin	MESH:C472645	79784	Chemical	Gene	filaments|nmod|START_ENTITY order|nmod|filaments Stabilization|nmod|order Stabilization|dep|evidence evidence|acl|coexisting coexisting|dobj|conformations conformations|nmod|END_ENTITY	Stabilization of helical order in the thick filaments by blebbistatin : further evidence of coexisting multiple conformations of myosin .
1699653	0	bleomycin	65,74	CHOP	78,82	bleomycin	CHOP	MESH:D001761	1649	Chemical	Gene	START_ENTITY|nmod|therapy therapy|compound|END_ENTITY	A randomized comparison of methotrexate dose and the addition of bleomycin to CHOP therapy for diffuse_large_cell_lymphoma and other non-Hodgkin 's _ lymphomas .
6171276	0	bleomycin	38,47	DNA_polymerase_alpha	14,34	bleomycin	DNA polymerase alpha	MESH:D001761	5422	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of DNA_polymerase_alpha by bleomycin .
10639534	0	bleomycin	22,31	E-selectin	8,18	bleomycin	E-selectin	MESH:D001761	20339(Tax:10090)	Chemical	Gene	induced|compound|START_ENTITY END_ENTITY|nmod|induced	Role of E-selectin in bleomycin induced lung_fibrosis in mice .
10934155	0	bleomycin	75,84	Gelatinase_B	0,12	bleomycin	Gelatinase B	MESH:D001761	17395(Tax:10090)	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Gelatinase_B is required for alveolar bronchiolization after intratracheal bleomycin .
26526764	0	bleomycin	59,68	NOS2	8,12	bleomycin	NOS2	MESH:D001761	18126(Tax:10090)	Chemical	Gene	response|nmod|START_ENTITY Role|nmod|response Role|nmod|END_ENTITY	Role of NOS2 in pulmonary_injury and repair in response to bleomycin .
2431800	0	bleomycin	63,72	O6-alkylguanine-DNA_alkyltransferase	23,59	bleomycin	O6-alkylguanine-DNA alkyltransferase	MESH:D001761	25332(Tax:10116)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of rat liver O6-alkylguanine-DNA_alkyltransferase by bleomycin .
20101203	0	bleomycin	36,45	PARP-1	14,20	bleomycin	PARP-1	MESH:D001761	142	Chemical	Gene	response|nmod|START_ENTITY END_ENTITY|nmod|response	Activation of PARP-1 in response to bleomycin depends on the Ku antigen and protein phosphatase 5 .
21597742	0	bleomycin	28,37	chop	176,180	bleomycin	chop	MESH:D001761	1649	Chemical	Gene	combination|amod|START_ENTITY combination|amod|chemotherapy chemotherapy|nmod|patients patients|amod|non-elegible non-elegible|dep|END_ENTITY	Mitoxantrone , Etoposide and bleomycin -LRB- meb -RRB- chemotherapy in non-hodgkins-lymphoma patients non-elegible for standard cyclophosphamide , Doxorubicin , vincristine and prednisone -LRB- chop -RRB- combination .
6157665	0	bleomycin	61,70	dopamine-beta-hydroxylase	14,39	bleomycin	dopamine-beta-hydroxylase	MESH:D001761	1621	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of dopamine-beta-hydroxylase , A copper enzyme , by bleomycin .
6188468	0	bleomycin	47,56	dopamine-beta-hydroxylase	18,43	bleomycin	dopamine-beta-hydroxylase	MESH:D001761	1621	Chemical	Gene	Photolabelling|nmod|START_ENTITY Photolabelling|nmod|END_ENTITY	Photolabelling of dopamine-beta-hydroxylase by bleomycin .
7504622	0	bleomycin	98,107	granulocyte-macrophage_colony-stimulating_factor	8,56	bleomycin	granulocyte-macrophage colony-stimulating factor	MESH:D001761	12981(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Role Role|nmod|END_ENTITY	Role of granulocyte-macrophage_colony-stimulating_factor in pulmonary_fibrosis induced in mice by bleomycin .
10414879	0	bleomycin	63,72	interferon-alpha2a	22,40	bleomycin	interferon-alpha2a	MESH:D001761	3440	Chemical	Gene	trial|nmod|START_ENTITY trial|nmod|END_ENTITY	A randomized trial of interferon-alpha2a and zidovudine versus bleomycin and zidovudine for AIDS-related Kaposi 's _ sarcoma .
7504928	0	bleomycin	73,82	interleukin-6	45,58	bleomycin	interleukin-6	MESH:D001761	24498(Tax:10116)	Chemical	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Regulation of rat pulmonary endothelial cell interleukin-6 production by bleomycin : effects of cellular fatty_acid composition .
22037577	0	bleomycin	105,114	vFLIP	74,79	bleomycin	vFLIP	MESH:D001761	4961494(Tax:37296)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Novel regulatory role for Kaposi 's _ sarcoma-associated_herpesvirus-encoded vFLIP in chemosensitization to bleomycin .
19857072	0	boldine	23,30	adiponectin	39,50	boldine	adiponectin	MESH:C011686	9370	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	The aporphine alkaloid boldine induces adiponectin expression and regulation in 3T3-L1 cells .
1326946	0	bombesin	38,46	C-6	77,80	bombesin	C-6	MESH:D001839	24237(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|nmod|cells cells|compound|END_ENTITY	Activation of neuromedin_B-preferring bombesin receptors on rat glioblastoma C-6 cells increases cellular Ca2 + and phosphoinositides .
4451816	0	bombesin	19,27	Gastrin	0,7	bombesin	Gastrin	MESH:D001839	100685087	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|END_ENTITY	Gastrin release by bombesin in the dog .
7232226	0	bombesin	76,84	Gastrin	0,7	bombesin	Gastrin	MESH:D001839	100685087	Chemical	Gene	hypersensitivity|nmod|START_ENTITY release|dobj|hypersensitivity release|nsubj|END_ENTITY	Gastrin release after truncal vagotomy in fistula dogs : hypersensitivity to bombesin but not bethanechol .
21192430	0	bombesin	11,19	IFN-induced_fever_and_AVP	23,48	bombesin	IFN-induced fever and AVP	MESH:D001839	24221(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|content content|compound|END_ENTITY	-LSB- Effect of bombesin on IFN-induced_fever_and_AVP content in brain of rats -RSB- .
7588257	7	bombesin	1404,1412	PYY	1461,1464	bombesin	PYY	MESH:D001839	287730(Tax:10116)	Chemical	Gene	induced|nsubj|START_ENTITY induced|dobj|release release|nmod|END_ENTITY	Similarly , bombesin -LRB- 10 -LRB- -7 -RRB- M -RRB- induced a marked biphasic release of PYY and GLP-1 .
17226786	0	bombesin	101,109	c-Fos	53,58	bombesin	c-Fos	MESH:D001839	14281(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY accumulation|acl|induced accumulation|amod|END_ENTITY	Protein_kinase_D2 potentiates MEK/ERK/RSK signaling , c-Fos accumulation and DNA synthesis induced by bombesin in Swiss_3T3 cells .
8435758	0	bombesin	11,19	c-fos	28,33	bombesin	c-fos	MESH:D001839	314322(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|protein protein|amod|END_ENTITY	Peripheral bombesin induces c-fos protein in the rat brain .
1516647	0	bombesin	11,19	cholecystokinin	125,140	bombesin	cholecystokinin	MESH:D001839	25298(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|acl|END_ENTITY	Effects of bombesin , of a new bombesin agonist -LRB- BIM187 -RRB- and a new antagonist -LRB- BIM189 -RRB- on food intake in rats , in relation to cholecystokinin .
2465695	0	bombesin	14,22	cholecystokinin	56,71	bombesin	cholecystokinin	MESH:D001839	100735029	Chemical	Gene	receptors|compound|START_ENTITY Regulation|nmod|receptors Regulation|nmod|END_ENTITY	Regulation of bombesin receptors on pancreatic acini by cholecystokinin .
1012339	0	bombesin	11,19	erythropoietin	23,37	bombesin	erythropoietin	MESH:D001839	404002(Tax:9615)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|production production|compound|END_ENTITY	Effects of bombesin on erythropoietin production in the anaesthetized dog .
3526356	0	bombesin	10,18	gastric_inhibitory_polypeptide	67,97	bombesin	gastric inhibitory polypeptide	MESH:D001839	25040(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|release release|nmod|END_ENTITY	Effect of bombesin and gastrin-releasing_peptide on the release of gastric_inhibitory_polypeptide and insulin in rats .
1332139	6	bombesin	1181,1189	gastrin	1199,1206	bombesin	gastrin	MESH:D001839	100685087	Chemical	Gene	START_ENTITY|acl|provoked provoked|dobj|release release|compound|END_ENTITY	-LSB- D-Phe6 -RSB- Bombesin -LRB- 6-13 -RRB- - propylamide -LRB- BIM -RRB- , a member of another class of antagonists , reported previously to be the most potent antagonist , in vitro , on the other hand , enhanced bombesin provoked gastrin release in rats .
1438988	0	bombesin	22,30	gastrin	72,79	bombesin	gastrin	MESH:D001839	25320(Tax:10116)	Chemical	Gene	antagonist|compound|START_ENTITY antagonist|nmod|levels levels|compound|END_ENTITY	High potency of a new bombesin antagonist -LRB- RC-3095 -RRB- in inhibiting serum gastrin levels ; comparison of different routes of administration .
1691518	0	bombesin	70,78	gastrin	8,15	bombesin	gastrin	MESH:D001839	25320(Tax:10116)	Chemical	Gene	action|nmod|START_ENTITY Role|nmod|action Role|nmod|END_ENTITY	Role of gastrin and cholecystokinin in the growth-promoting action of bombesin on the gastroduodenal mucosa and the pancreas .
1810583	0	bombesin	100,108	gastrin	43,50	bombesin	gastrin	MESH:D001839	2520	Chemical	Gene	chickens|nmod|START_ENTITY levels|nmod|chickens levels|nmod|END_ENTITY	Tissue and plasma levels of immunoreactive gastrin and cholecystokinin in chickens with and without bombesin .
2421269	0	bombesin	18,26	gastrin	81,88	bombesin	gastrin	MESH:D001839	25320(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY mediated|dobj|effect mediated|nmod|release release|nmod|END_ENTITY	Trophic effect of bombesin on the rat pancreas : is it mediated by the release of gastrin or cholecystokinin ?
2567566	0	bombesin	23,31	gastrin	85,92	bombesin	gastrin	MESH:D001839	25320(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Differential effect of bombesin on intraluminal and intravascular release of gastric gastrin and somatostatin in anaesthetized rats .
2847254	1	bombesin	250,258	gastrin	331,338	bombesin	gastrin	MESH:D001839	25320(Tax:10116)	Chemical	Gene	response|nmod|START_ENTITY reported|nmod|response reported|parataxis|potentiated potentiated|dobj|response response|compound|END_ENTITY	We and others have recently reported an involvement of calcium -LRB- Ca2 + -RRB- - mediated intracellular pathways in the release of antral gastrin in response to bombesin -LRB- BBS -RRB- , while cyclic_adenosine_3 ' 5 ' - monophosphate -LRB- cAMP -RRB- potentiated the gastrin response to BBS .
2858981	0	bombesin	53,61	gastrin	32,39	bombesin	gastrin	MESH:D001839	25320(Tax:10116)	Chemical	Gene	antiserum|compound|START_ENTITY mediated|nmod|antiserum mediated|dobj|secretion secretion|compound|END_ENTITY	Inhibition of neurally mediated gastrin secretion by bombesin antiserum .
2877911	0	bombesin	119,127	gastrin	163,170	bombesin	gastrin	MESH:D001839	25320(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|release release|compound|END_ENTITY	Neural and paracrine regulation of gastrin release using rat antral mucosa in tissue culture -- the effect of carbachol , bombesin , and anti-somatostatin antibody on gastrin release .
2877911	0	bombesin	119,127	gastrin	35,42	bombesin	gastrin	MESH:D001839	25320(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY regulation|dep|effect regulation|nmod|release release|compound|END_ENTITY	Neural and paracrine regulation of gastrin release using rat antral mucosa in tissue culture -- the effect of carbachol , bombesin , and anti-somatostatin antibody on gastrin release .
3569746	0	bombesin	36,44	gastrin	48,55	bombesin	gastrin	MESH:D001839	25320(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Effects of exogenous and endogenous bombesin on gastrin secretion from rat antral mucosa in tissue culture .
367854	0	bombesin	64,72	gastrin	15,22	bombesin	gastrin	MESH:D001839	100685087	Chemical	Gene	effect|nmod|START_ENTITY release|dep|effect release|compound|END_ENTITY	Stimulation of gastrin release and gastric secretion : effect of bombesin and a nonapeptide in fistula dogs with and without fundic vagotomy .
3749030	0	bombesin	29,37	gastrin	138,145	bombesin	gastrin	MESH:D001839	25320(Tax:10116)	Chemical	Gene	actions|acl|START_ENTITY actions|acl|causing causing|dobj|release release|nmod|END_ENTITY	Comparison of the actions of bombesin , gastrin-releasing peptide-27 , neuromedin_B , and gastrin-releasing peptide-10 in causing release of gastrin and gastric inhibitory peptide in rats .
6116435	0	bombesin	83,91	gastrin	15,22	bombesin	gastrin	MESH:D001839	25320(Tax:10116)	Chemical	Gene	stomach|nmod|START_ENTITY secretion|nmod|stomach secretion|nsubj|Stimulation Stimulation|nmod|END_ENTITY	Stimulation of gastrin and somatostatin secretion from the isolated rat stomach by bombesin .
6405629	0	bombesin	84,92	gastrin	55,62	bombesin	gastrin	MESH:D001839	100685087	Chemical	Gene	given|xcomp|START_ENTITY dogs|acl|given serum|nmod|dogs serum|dobj|levels levels|compound|END_ENTITY	Relation of gastric_acid and pepsin secretion to serum gastrin levels in dogs given bombesin and gastrin-17 .
6732491	1	bombesin	85,93	gastrin	42,49	bombesin	gastrin	MESH:D001839	445524(Tax:9823)	Chemical	Gene	Release|acl|START_ENTITY Release|nmod|END_ENTITY	Release of gastrin and cholecystokinin in response to bombesin in pigs .
6832566	0	bombesin	26,34	gastrin	53,60	bombesin	gastrin	MESH:D001839	25320(Tax:10116)	Chemical	Gene	administration|nmod|START_ENTITY stimulates|nsubj|administration stimulates|dobj|proliferation proliferation|compound|END_ENTITY	Chronic administration of bombesin stimulates antral gastrin cell proliferation in the rat .
7355392	0	bombesin	71,79	gastrin	10,17	bombesin	gastrin	MESH:D001839	100685087	Chemical	Gene	acidification|compound|START_ENTITY Hormonal|nmod|acidification Hormonal|dep|cholecystokinin cholecystokinin|compound|END_ENTITY	Hormonal -LRB- gastrin , secretin , cholecystokinin -RRB- and secretory effects of bombesin and duodenal acidification in dogs .
8446002	0	bombesin	10,18	gastrin	68,75	bombesin	gastrin	MESH:D001839	25320(Tax:10116)	Chemical	Gene	D-Phe6-BN|amod|START_ENTITY Effect|nmod|D-Phe6-BN OMe|nsubj|Effect OMe|nmod|release release|compound|END_ENTITY	Effect of bombesin antagonist D-Phe6-BN -LRB- 6-13 -RRB- OMe on vagally induced gastrin release from perfused rat stomach .
21711115	0	bombesin	32,40	gastrin-releasing_peptide	63,88	bombesin	gastrin-releasing peptide	MESH:D001839	2922	Chemical	Gene	analog|compound|START_ENTITY evaluation|nmod|analog evaluation|nmod|receptors receptors|amod|END_ENTITY	Preclinical evaluation of a new bombesin analog for imaging of gastrin-releasing_peptide receptors .
8243536	0	bombesin	103,111	gastrin-releasing_peptide	48,73	bombesin	gastrin-releasing peptide	MESH:D001839	171101(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Structure-activity requirements of bombesin for gastrin-releasing_peptide - and neuromedin_B-preferring bombesin receptors in rat brain .
8243536	0	bombesin	35,43	gastrin-releasing_peptide	48,73	bombesin	gastrin-releasing peptide	MESH:D001839	171101(Tax:10116)	Chemical	Gene	requirements|nmod|START_ENTITY requirements|nmod|receptors receptors|amod|END_ENTITY	Structure-activity requirements of bombesin for gastrin-releasing_peptide - and neuromedin_B-preferring bombesin receptors in rat brain .
1980937	0	bombesin	30,38	growth_hormone	50,64	bombesin	growth hormone	MESH:D001839	81668(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nsubj|effects	Estrogen-dependent effects of bombesin on in vivo growth_hormone secretion in the rat .
2328688	0	bombesin	90,98	growth_hormone	15,29	bombesin	growth hormone	MESH:D001839	81668(Tax:10116)	Chemical	Gene	aggregates|nmod|START_ENTITY release|nmod|aggregates release|compound|END_ENTITY	Stimulation of growth_hormone and prolactin release from rat pituitary cell aggregates by bombesin - and ranatensin-like peptides is potentiated by estradiol , 5 alpha-dihydrotestosterone , and dexamethasone .
2862018	0	bombesin	76,84	growth_hormone	24,38	bombesin	growth hormone	MESH:D001839	81668(Tax:10116)	Chemical	Gene	injection|nmod|START_ENTITY secretion|nmod|injection secretion|amod|END_ENTITY	Prolonged inhibition of growth_hormone secretion by peripheral injection of bombesin is mediated by somatostatin in the rat .
6881348	0	bombesin	34,42	motilin	15,22	bombesin	motilin	MESH:D001839	481748(Tax:9615)	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|Stimulation Stimulation|nmod|END_ENTITY	Stimulation of motilin release by bombesin in dogs .
15110809	0	bombesin	124,132	occludin	82,90	bombesin	occludin	MESH:D001839	83497(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY expression|dep|effect expression|compound|END_ENTITY	Experimental obstructive_jaundice disrupts intestinal mucosal barrier by altering occludin expression : beneficial effect of bombesin and neurotensin .
7525357	0	bombesin	94,102	p125FAK	62,69	bombesin	p125FAK	MESH:D001839	14083(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Botulinum C3 exoenzyme blocks the tyrosine phosphorylation of p125FAK and paxillin induced by bombesin and endothelin .
9083073	0	bombesin	41,49	p130	28,32	bombesin	p130	MESH:D001839	70769(Tax:10090)	Chemical	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of p130 -LRB- cas -RRB- by bombesin , lysophosphatidic_acid , phorbol_esters , and platelet-derived growth factor .
2390922	0	bombesin	27,35	pancreatic_polypeptide	57,79	bombesin	pancreatic polypeptide	MESH:D001839	490944(Tax:9615)	Chemical	Gene	secretion|amod|START_ENTITY secretion|amod|END_ENTITY	Role of cholecystokinin in bombesin - and meal-stimulated pancreatic_polypeptide secretion in dogs .
8661226	0	bombesin	26,34	pp125FAK	73,81	bombesin	pp125FAK	MESH:D001839	14083(Tax:10090)	Chemical	Gene	stimulation|compound|START_ENTITY stimulation|nmod|END_ENTITY	Actin disruption inhibits bombesin stimulation of focal_adhesion_kinase -LRB- pp125FAK -RRB- in prostate_carcinoma .
8479615	0	bombesin	26,34	prolactin	73,82	bombesin	prolactin	MESH:D001839	24683(Tax:10116)	Chemical	Gene	administration|nmod|START_ENTITY blocks|nsubj|administration blocks|dobj|surge surge|compound|END_ENTITY	Central administration of bombesin blocks the estrogen-induced afternoon prolactin surge .
22341830	0	boophilin	46,55	thrombin	59,67	boophilin	thrombin	null	280685(Tax:9913)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Expression and functional characterization of boophilin , a thrombin inhibitor from Rhipicephalus -LRB- Boophilus -RRB- microplus midgut .
2484080	0	bopindolol	10,20	renin	24,29	bopindolol	renin	MESH:C036007	24715(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Effect of bopindolol on renin secretion and renal excretory function in rats .
14743504	0	borderline	39,49	BRCA1	14,19	borderline	BRCA1	null	672	Chemical	Gene	protein|nmod|START_ENTITY protein|nummod|END_ENTITY	Expression of BRCA1 protein in benign , borderline , and malignant_epithelial_ovarian_neoplasms and its relationship to methylation and allelic loss of the BRCA1 gene .
8872066	0	borderline	50,60	plasminogen_activator_inhibitor_1	13,46	borderline	plasminogen activator inhibitor 1	null	5054	Chemical	Gene	hypertension|amod|START_ENTITY END_ENTITY|nmod|hypertension	Elevation of plasminogen_activator_inhibitor_1 in borderline hypertension is linked to concomitant metabolic disturbances .
19583488	0	borderline	9,19	thyrotropin_receptor	42,62	borderline	thyrotropin receptor	null	7253	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Cases of borderline in vitro constitutive thyrotropin_receptor activity : how to decide whether a thyrotropin_receptor mutation is constitutively active or not ?
12128096	0	boric_acid	43,53	CD-1	67,71	boric acid	CD-1	MESH:C032688	111334(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|compound|END_ENTITY	Periods of vertebral column sensitivity to boric_acid treatment in CD-1 mice in utero .
1765217	0	boric_acid	25,35	CD-1	46,50	boric acid	CD-1	MESH:C032688	111334(Tax:10090)	Chemical	Gene	mice|amod|START_ENTITY mice|appos|END_ENTITY	Reproductive_toxicity of boric_acid in Swiss -LRB- CD-1 -RRB- mice : assessment using the continuous breeding protocol .
21811923	0	borneol	11,18	P-glycoprotein	69,83	borneol	P-glycoprotein	MESH:C022871	287115(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|transport transport|nmod|substrates substrates|amod|END_ENTITY	Effects of borneol on the intestinal transport and absorption of two P-glycoprotein substrates in rats .
10836047	0	boroarginine	64,76	thrombin	77,85	boroarginine	thrombin	null	2147	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	7-Azabicycloheptane_carboxylic_acid : a proline replacement in a boroarginine thrombin inhibitor .
22083870	0	borocarbonitrides	50,67	CO2	21,24	borocarbonitrides	CO2	null	717	Chemical	Gene	uptake|nmod|START_ENTITY uptake|nmod|END_ENTITY	Remarkable uptake of CO2 and CH4 by graphene-Like borocarbonitrides , BxCyNz .
25703358	0	boron	62,67	BF2	99,102	boron	BF2	MESH:D001895	2290	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Synthesis , spectroscopic and catalytic properties of some new boron hybrid molecule derivatives by BF2 and BPh2 chelation .
16103374	0	boron	39,44	BOR1	31,35	boron	BOR1	MESH:D001895	819329(Tax:3702)	Chemical	Gene	transporter|compound|START_ENTITY Endocytosis|appos|transporter Endocytosis|nmod|END_ENTITY	Endocytosis and degradation of BOR1 , a boron transporter of Arabidopsis_thaliana , regulated by boron availability .
16103374	0	boron	95,100	BOR1	31,35	boron	BOR1	MESH:D001895	819329(Tax:3702)	Chemical	Gene	availability|compound|START_ENTITY regulated|nmod|availability regulated|nsubj|Endocytosis Endocytosis|nmod|END_ENTITY	Endocytosis and degradation of BOR1 , a boron transporter of Arabidopsis_thaliana , regulated by boron availability .
16805739	0	boron	93,98	BOR1	85,89	boron	BOR1	MESH:D001895	819329(Tax:3702)	Chemical	Gene	transporter|compound|START_ENTITY overexpression|appos|transporter overexpression|nmod|END_ENTITY	Improvement of seed yields under boron-limiting conditions through overexpression of BOR1 , a boron transporter for xylem loading , in Arabidopsis_thaliana .
16923078	0	boron	33,38	BOR1	9,13	boron	BOR1	MESH:D001895	855446(Tax:4932)	Chemical	Gene	transport|compound|START_ENTITY Roles|nmod|transport Roles|nmod|END_ENTITY	Roles of BOR1 , DUR3 , and FPS1 in boron transport and tolerance in Saccharomyces_cerevisiae .
22301967	0	boron	50,55	BOR1	69,73	boron	BOR1	MESH:D001895	819329(Tax:3702)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Polar localization and endocytic degradation of a boron transporter , BOR1 , is dependent on specific tyrosine residues .
23414066	0	boron	60,65	BOR1	50,54	boron	BOR1	MESH:D001895	855446(Tax:4932)	Chemical	Gene	transporter|compound|START_ENTITY characterization|nmod|transporter characterization|nmod|END_ENTITY	Functional characterization of Citrus macrophylla BOR1 as a boron transporter .
19380233	0	boron	51,56	RA-3	38,42	boron	RA-3	MESH:D001895	474223	Chemical	Gene	therapy|compound|START_ENTITY therapy|compound|END_ENTITY	Dosimetry and radiobiology at the new RA-3 reactor boron neutron capture therapy -LRB- BNCT -RRB- facility : application to the treatment of experimental oral_cancer .
26133616	0	boron	41,46	RA-3	94,98	boron	RA-3	MESH:D001895	474223	Chemical	Gene	therapy|compound|START_ENTITY situ|dobj|therapy situ|nmod|lung_tumors lung_tumors|nmod|reactor reactor|compound|END_ENTITY	Toward a clinical application of ex situ boron neutron capture therapy for lung_tumors at the RA-3 reactor in Argentina .
18705502	0	boron	11,16	enamelin	51,59	boron	enamelin	MESH:D001895	289525(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of boron and fluoride on the expression of enamelin in rat incisor -RSB- .
18283241	0	boron	15,20	leptin	46,52	boron	leptin	MESH:D001895	25608(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY effects|nmod|administration effects|nmod|END_ENTITY	The effects of boron administration on plasma leptin and lactate levels in ovariectomized rats which had acute swimming exercise .
21283875	0	boronate	33,41	MIDA	28,32	boronate	MIDA	CHEBI:50978	55471	Chemical	Gene	START_ENTITY|nsubj|Synthesis Synthesis|nmod|END_ENTITY	Synthesis and properties of MIDA boronate containing aromatic_amino_acids : new peptide building blocks .
23205640	0	boronate	99,107	MIDA	94,98	boronate	MIDA	CHEBI:50978	55471	Chemical	Gene	synthesis|amod|START_ENTITY synthesis|compound|END_ENTITY	Mechanistic studies into amine-mediated electrophilic arene borylation and its application in MIDA boronate synthesis .
18783201	0	boronic_acid	10,22	dipeptidyl_peptidase_IV	37,60	boronic acid	dipeptidyl peptidase IV	CHEBI:38267	1803	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Dipeptide boronic_acid inhibitors of dipeptidyl_peptidase_IV : determinants of potency and in vivo efficacy and safety .
18635003	0	boronic_acid	30,42	prostate-specific_antigen	77,102	boronic acid	prostate-specific antigen	CHEBI:38267	354	Chemical	Gene	START_ENTITY|dobj|inhibitors inhibitors|nmod|END_ENTITY	Potent and selective peptidyl boronic_acid inhibitors of the serine protease prostate-specific_antigen .
1800952	0	boronic_acid	36,48	thrombin	49,57	boronic acid	thrombin	CHEBI:38267	29251(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|inhibitor inhibitor|compound|END_ENTITY	Anticoagulant activity of a peptide boronic_acid thrombin inhibitor by various routes of administration in rats .
9204385	0	boronic_acid_dipeptides	56,79	CD26	39,43	boronic acid dipeptides	CD26	null	1803	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of dipeptidyl_peptidase_IV -LRB- CD26 -RRB- by peptide boronic_acid_dipeptides .
9204385	0	boronic_acid_dipeptides	56,79	dipeptidyl_peptidase_IV	14,37	boronic acid dipeptides	dipeptidyl peptidase IV	null	1803	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of dipeptidyl_peptidase_IV -LRB- CD26 -RRB- by peptide boronic_acid_dipeptides .
2460436	0	boronic_acids	8,21	chymase	50,57	boronic acids	chymase	MESH:D001897	29265(Tax:10116)	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|release release|amod|END_ENTITY	Peptide boronic_acids , substrate analogs , inhibit chymase , and histamine release from rat mast cells .
14563161	0	borrelidin	29,39	threonyl-tRNA_synthetase	80,104	borrelidin	threonyl-tRNA synthetase	MESH:C005066	294810(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY mediated|nsubjpass|effects mediated|parataxis|involved involved|nsubjpass|END_ENTITY	Anti-angiogenesis effects of borrelidin are mediated through distinct pathways : threonyl-tRNA_synthetase and caspases are independently involved in suppression of proliferation and induction of apoptosis in endothelial cells .
23281998	0	bortezomib	31,41	ADAMTS13	0,8	bortezomib	ADAMTS13	MESH:C400082	11093	Chemical	Gene	depletion|nmod|START_ENTITY depletion|compound|END_ENTITY	ADAMTS13 antibody depletion by bortezomib in thrombotic_thrombocytopenic_purpura .
15791457	0	bortezomib	118,128	BCL-2	10,15	bortezomib	BCL-2	MESH:C400082	596	Chemical	Gene	overexpression|nmod|START_ENTITY overexpression|nsubj|END_ENTITY	Targeting BCL-2 overexpression in various human malignancies through NF-kappaB inhibition by the proteasome inhibitor bortezomib .
16022909	0	bortezomib	60,70	BCL-2	13,18	bortezomib	BCL-2	MESH:C400082	596	Chemical	Gene	inhibition|nmod|START_ENTITY levels|nmod|inhibition levels|compound|END_ENTITY	Reduction in BCL-2 levels by 26S proteasome inhibition with bortezomib is associated with induction of apoptosis in small_cell_lung_cancer .
17828309	0	bortezomib	56,66	BCL-2	0,5	bortezomib	BCL-2	MESH:C400082	596	Chemical	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	BCL-2 family regulation by the 20S proteasome inhibitor bortezomib .
25975837	0	bortezomib	60,70	Bax	112,115	bortezomib	Bax	MESH:C400082	581	Chemical	Gene	START_ENTITY|nmod|upregulation upregulation|nmod|END_ENTITY	ALK-negative anaplastic_large_cell_lymphoma is sensitive to bortezomib through Noxa upregulation and release of Bax from Bcl-2 .
14513055	0	bortezomib	25,35	Bcl-2	110,115	bortezomib	Bcl-2	MESH:C400082	596	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|mitochondrial_injury mitochondrial_injury|acl|induced induced|nmod|HA14-1 HA14-1|compound|END_ENTITY	The proteasome inhibitor bortezomib promotes mitochondrial_injury and apoptosis induced by the small molecule Bcl-2 inhibitor HA14-1 in multiple_myeloma cells .
19270531	0	bortezomib	48,58	Bcl-2	0,5	bortezomib	Bcl-2	MESH:C400082	596	Chemical	Gene	interact|nmod|START_ENTITY interact|nsubj|antagonists antagonists|amod|END_ENTITY	Bcl-2 antagonists interact synergistically with bortezomib in DLBCL cells in association with JNK activation and induction of ER stress .
24679008	0	bortezomib	70,80	Bcl-2	30,35	bortezomib	Bcl-2	MESH:C400082	596	Chemical	Gene	obatoclax_mesylate|dobj|START_ENTITY obatoclax_mesylate|nsubj|study study|nmod|inhibitor inhibitor|compound|END_ENTITY	A phase I/II study of the pan Bcl-2 inhibitor obatoclax_mesylate plus bortezomib for relapsed or refractory_mantle_cell_lymphoma .
26968249	0	bortezomib	32,42	C/EBPb	0,6	bortezomib	C/EBPb	MESH:C400082	1051	Chemical	Gene	regulates|advcl|START_ENTITY regulates|nsubj|END_ENTITY	C/EBPb regulates sensitivity to bortezomib in prostate_cancer cells by inducing REDD1 and autophagosome-lysosome fusion .
23470832	0	bortezomib	31,41	CD23	9,13	bortezomib	CD23	MESH:C400082	2208	Chemical	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	-LSB- Loss of CD23 expression after bortezomib plus dexamethasone therapy in CCND1/IGH-positive multiple_myeloma -RSB- .
19508976	0	bortezomib	15,25	CD4	35,38	bortezomib	CD4	MESH:C400082	920	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Treatment with bortezomib of human CD4 + T cells preserves natural regulatory T cells and allows the emergence of a distinct suppressor T-cell population .
18689866	0	bortezomib	38,48	CHOP	54,58	bortezomib	CHOP	MESH:C400082	1649	Chemical	Gene	plus|compound|START_ENTITY study|nmod|plus END_ENTITY|nsubj|study	Phase I study of proteasome inhibitor bortezomib plus CHOP in patients with advanced , aggressive T-cell or NK/T-cell _ lymphoma .
22479278	0	bortezomib	22,32	CHOP	38,42	bortezomib	CHOP	MESH:C400082	1649	Chemical	Gene	plus|amod|START_ENTITY study|nmod|plus END_ENTITY|nsubj|study	A phase I/II study of bortezomib plus CHOP every 2 weeks -LRB- CHOP-14 -RRB- in patients with advanced-stage diffuse_large_B-cell_lymphomas .
20729919	0	bortezomib	26,36	CIP2A	0,5	bortezomib	CIP2A	MESH:C400082	57650	Chemical	Gene	effects|nmod|START_ENTITY mediates|dobj|effects mediates|nsubj|END_ENTITY	CIP2A mediates effects of bortezomib on phospho-Akt and apoptosis in hepatocellular_carcinoma cells .
22537901	0	bortezomib	21,31	CIP2A	0,5	bortezomib	CIP2A	MESH:C400082	57650	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	CIP2A is a target of bortezomib in human triple negative breast_cancer cells .
24789441	0	bortezomib	41,51	CIP2A	8,13	bortezomib	CIP2A	MESH:C400082	57650	Chemical	Gene	effect|nmod|START_ENTITY Role|nmod|effect Role|nmod|END_ENTITY	Role of CIP2A in the antitumor effect of bortezomib in colon_cancer .
16954476	0	bortezomib	41,51	Cyclin_D1	0,9	bortezomib	Cyclin D1	MESH:C400082	595	Chemical	Gene	treatment|amod|START_ENTITY END_ENTITY|nmod|treatment	Cyclin_D1 overexpression and response to bortezomib treatment in a breast_cancer model .
18507008	0	bortezomib	10,20	EGFR	24,28	bortezomib	EGFR	MESH:C400082	1956	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of bortezomib on EGFR expression in head_and_neck_squamous_cell_carcinoma cell lines .
21750205	0	bortezomib	69,79	EGFR	49,53	bortezomib	EGFR	MESH:C400082	1956	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Early tumor progression associated with enhanced EGFR signaling with bortezomib , cetuximab , and radiotherapy for head_and_neck_cancer .
21729547	0	bortezomib	39,49	ERK	71,74	bortezomib	ERK	MESH:C400082	5594	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of different concentrations of bortezomib on the expression of ERK , JNK and P38 in daunorubicin-resistant K562 cells -RSB- .
21269258	0	bortezomib	49,59	Focal_adhesion_kinase	0,21	bortezomib	Focal adhesion kinase	MESH:C400082	5747	Chemical	Gene	target|nmod|START_ENTITY END_ENTITY|nmod|target	Focal_adhesion_kinase as a therapeutic target of bortezomib .
25373733	0	bortezomib	110,120	HIF-1a	39,45	bortezomib	HIF-1a	MESH:C400082	3091	Chemical	Gene	trial|nmod|START_ENTITY END_ENTITY|dep|trial	Targeting hypoxia-inducible_factor-1a -LRB- HIF-1a -RRB- in combination with antiangiogenic therapy : A phase I trial of bortezomib plus bevacizumab .
23894194	0	bortezomib	25,35	IL-8	46,50	bortezomib	IL-8	MESH:C400082	3576	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Proteasome inhibition by bortezomib increases IL-8 expression in androgen-independent prostate_cancer cells : the role of IKKa .
16174760	0	bortezomib	95,105	NF-kappaB	0,9	bortezomib	NF-kappaB	MESH:C400082	18033(Tax:10090)	Chemical	Gene	efficacy|nmod|START_ENTITY END_ENTITY|dep|efficacy	NF-kappaB as a target for the prevention of graft-versus-host_disease : comparative efficacy of bortezomib and PS-1145 .
18928584	0	bortezomib	33,43	NF-kappaB	47,56	bortezomib	NF-kappaB	MESH:C400082	4790	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	-LSB- Effects of proteasome inhibitor bortezomib on NF-kappaB activity and ICAM-1 mRNA expression of K562 cells -RSB- .
18949621	0	bortezomib	26,36	NF-kappaB	4,13	bortezomib	NF-kappaB	MESH:C400082	4790	Chemical	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	The NF-kappaB inhibitors -LRB- bortezomib and DHMEQ -RRB- sensitise rituximab-resistant AIDS-B-non-Hodgkin_lymphoma to apoptosis by various chemotherapeutic drugs .
20515939	0	bortezomib	101,111	NF-kappaB	4,13	bortezomib	NF-kappaB	MESH:C400082	4790	Chemical	Gene	has|nmod|START_ENTITY has|nsubj|LC-1 LC-1|amod|END_ENTITY	The NF-kappaB inhibitor LC-1 has single agent activity in multiple_myeloma cells and synergizes with bortezomib .
22512091	0	bortezomib	25,35	NF-kappaB	112,121	bortezomib	NF-kappaB	MESH:C400082	4790	Chemical	Gene	reverses|nsubj|START_ENTITY reverses|nmod|pathway pathway|amod|END_ENTITY	The proteasome inhibitor bortezomib reverses P-glycoprotein-mediated_leukemia multi-drug resistance through the NF-kappaB pathway .
20530581	0	bortezomib	55,65	PRDM1	0,5	bortezomib	PRDM1	MESH:C400082	639	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	PRDM1 is required for mantle cell lymphoma response to bortezomib .
16550004	0	bortezomib	21,31	PTEN	42,46	bortezomib	PTEN	MESH:C400082	5728	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Proteasome inhibitor bortezomib increases PTEN expression and enhances trastuzumab-induced growth inhibition in trastuzumab-resistant cells .
15767553	0	bortezomib	25,35	TRAIL	89,94	bortezomib	TRAIL	MESH:C400082	8743	Chemical	Gene	sensitizes|nsubj|START_ENTITY sensitizes|advcl|killing killing|nmod|receptor receptor|acl|ligand ligand|dobj|END_ENTITY	The proteasome inhibitor bortezomib sensitizes cells to killing by death receptor ligand TRAIL via BH3-only proteins Bik and Bim .
17620439	0	bortezomib	126,136	TRAIL	0,5	bortezomib	TRAIL	MESH:C400082	8743	Chemical	Gene	apoptosis|nmod|START_ENTITY therapy|dep|apoptosis therapy|amod|END_ENTITY	TRAIL therapy in non-small_cell_lung_cancer cells : sensitization to death receptor-mediated apoptosis by proteasome inhibitor bortezomib .
18716397	0	bortezomib	22,32	TRAIL	63,68	bortezomib	TRAIL	MESH:C400082	8743	Chemical	Gene	activity|nmod|START_ENTITY activity|nmod|END_ENTITY	Antitumor activity of bortezomib alone and in combination with TRAIL in human acute_myeloid_leukemia .
20542572	0	bortezomib	25,35	TRAIL	102,107	bortezomib	TRAIL	MESH:C400082	8743	Chemical	Gene	disrupts|nsubj|START_ENTITY disrupts|dobj|expression expression|appos|END_ENTITY	The proteasome inhibitor bortezomib disrupts tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- expression and natural killer -LRB- NK -RRB- cell killing of TRAIL receptor-positive multiple_myeloma cells .
20542572	0	bortezomib	25,35	TRAIL	160,165	bortezomib	TRAIL	MESH:C400082	8743	Chemical	Gene	disrupts|nsubj|START_ENTITY disrupts|dobj|expression expression|dep|killing killing|nmod|cells cells|amod|END_ENTITY	The proteasome inhibitor bortezomib disrupts tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- expression and natural killer -LRB- NK -RRB- cell killing of TRAIL receptor-positive multiple_myeloma cells .
20561413	0	bortezomib	11,21	TRAIL	57,62	bortezomib	TRAIL	MESH:C400082	8743	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|cells cells|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Effect of bortezomib on sensitization of HL-60 cells to TRAIL -RSB- .
22991197	0	bortezomib	119,129	TRAIL	84,89	bortezomib	TRAIL	MESH:C400082	8743	Chemical	Gene	combined|nmod|START_ENTITY protein|acl|combined protein|amod|END_ENTITY	Increased apoptosis induction in hepatocellular_carcinoma by a novel tumor-targeted TRAIL fusion protein combined with bortezomib .
20561442	0	bortezomib	11,21	VEGF	25,29	bortezomib	VEGF	MESH:C400082	7422	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effect of bortezomib on VEGF gene expression of endothelial cell line HMEC-1 and its possible mechanisms -RSB- .
17895889	0	bortezomib	89,99	heme_oxygenase-1	13,29	bortezomib	heme oxygenase-1	MESH:C400082	3162	Chemical	Gene	effect|nmod|START_ENTITY enhances|dobj|effect enhances|nsubj|Induction Induction|nmod|protoporphyrin protoporphyrin|amod|END_ENTITY	Induction of heme_oxygenase-1 by cobalt protoporphyrin enhances the antitumour effect of bortezomib in adult_T-cell_leukaemia cells .
20015241	0	bortezomib	22,32	hepatocyte_growth_factor	76,100	bortezomib	hepatocyte growth factor	MESH:C400082	3082	Chemical	Gene	response|acl|START_ENTITY END_ENTITY|nsubj|response	Treatment response to bortezomib in multiple myeloma correlates with plasma hepatocyte_growth_factor concentration and bone marrow thrombospondin concentration .
25791477	0	bortezomib	16,26	interleukin-8	37,50	bortezomib	interleukin-8	MESH:C400082	3576	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Anticancer drug bortezomib increases interleukin-8 expression in human monocytes .
16005577	0	bortezomib	103,113	nuclear_factor-kappaB	14,35	bortezomib	nuclear factor-kappaB	MESH:C400082	4790	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|Inhibition Inhibition|nmod|genes genes|compound|END_ENTITY	Inhibition of nuclear_factor-kappaB and target genes during combined therapy with proteasome inhibitor bortezomib and reirradiation in patients with recurrent head-and-neck_squamous_cell_carcinoma .
18684839	0	bortezomib	18,28	nuclear_factor-kappaB	32,53	bortezomib	nuclear factor-kappaB	MESH:C400082	4790	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|amod|END_ENTITY	Dynamic effect of bortezomib on nuclear_factor-kappaB activity and gene expression in tumor cells .
24113592	0	bortezomib	40,50	p21	19,22	bortezomib	p21	MESH:C400082	1026	Chemical	Gene	cytotoxicity|amod|START_ENTITY enhances|dobj|cytotoxicity enhances|nsubj|peptide peptide|amod|END_ENTITY	Thermally targeted p21 peptide enhances bortezomib cytotoxicity in androgen-independent prostate_cancer cell lines .
14612532	0	bortezomib	25,35	p53	70,73	bortezomib	p53	MESH:C400082	7157	Chemical	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|form form|nmod|END_ENTITY	The proteasome inhibitor bortezomib stabilizes a novel active form of p53 in human LNCaP-Pro5_prostate_cancer cells .
16166592	0	bortezomib	25,35	p53	139,142	bortezomib	p53	MESH:C400082	7157	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|generation generation|nmod|ROS ROS|nmod|status status|compound|END_ENTITY	The proteasome inhibitor bortezomib induces apoptosis in mantle-cell_lymphoma through generation of ROS and Noxa activation independent of p53 status .
17235352	0	bortezomib	25,35	p53	73,76	bortezomib	p53	MESH:C400082	7157	Chemical	Gene	acts|nsubj|START_ENTITY acts|nmod|combination combination|nmod|transfer transfer|compound|END_ENTITY	The proteasome inhibitor bortezomib acts differently in combination with p53 gene transfer or cytotoxic chemotherapy on NSCLC cells .
17363600	0	bortezomib	25,35	p53	58,61	bortezomib	p53	MESH:C400082	7157	Chemical	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	The proteasome inhibitor bortezomib acts independently of p53 and induces cell death via apoptosis and mitotic catastrophe in B-cell_lymphoma cell lines .
19661301	0	bortezomib	37,47	p53	73,76	bortezomib	p53	MESH:C400082	7157	Chemical	Gene	activity|nmod|START_ENTITY Inhibition|nmod|activity dependent|nsubj|Inhibition dependent|advmod|END_ENTITY	Inhibition of proteasome activity by bortezomib in renal_cancer cells is p53 dependent and VHL independent .
23357978	0	bortezomib	24,34	p53	134,137	bortezomib	p53	MESH:C400082	7157	Chemical	Gene	activity|nmod|START_ENTITY activity|nmod|END_ENTITY	Synergistic activity of bortezomib and HDACi in preclinical models of B-cell precursor acute_lymphoblastic_leukemia via modulation of p53 , PI3K/AKT , and NF-kB .
8640984	1	bosentan	101,109	ETA_and_ETB_receptor	146,166	bosentan	ETA and ETB receptor	MESH:C086232	24326(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|antagonist antagonist|compound|END_ENTITY	Acute effects of bosentan , an orally active , mixed endothelin ETA_and_ETB_receptor antagonist .
24583865	0	bosentan	59,67	Endothelin-1	0,12	bosentan	Endothelin-1	MESH:C086232	24323(Tax:10116)	Chemical	Gene	characterization|nmod|START_ENTITY receptors|dep|characterization receptors|amod|END_ENTITY	Endothelin-1 receptors in rat tissues : characterization by bosentan , ambrisentan and CI-1020 .
7544236	0	bosentan	137,145	Endothelin-1	0,12	bosentan	Endothelin-1	MESH:C086232	24323(Tax:10116)	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|expression expression|amod|END_ENTITY	Endothelin-1 expression in blood vessels of DOCA-salt hypertensive rats treated with the combined ETA/ETB _ endothelin_receptor antagonist bosentan .
10233186	0	bosentan	67,75	endothelin-1	83,95	bosentan	endothelin-1	MESH:C086232	1906	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Protection against aspirin-induced human gastric_mucosal_injury by bosentan , a new endothelin-1 receptor antagonist .
10534471	0	bosentan	101,109	endothelin-1	16,28	bosentan	endothelin-1	MESH:C086232	13614(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY Contribution|dep|effects Contribution|nmod|model model|amod|END_ENTITY	Contribution of endothelin-1 to myocardial_injury in a murine model of myocarditis : acute effects of bosentan , an endothelin receptor antagonist .
12450064	0	bosentan	75,83	endothelin-1	35,47	bosentan	endothelin-1	MESH:C086232	24323(Tax:10116)	Chemical	Gene	reversal|nmod|START_ENTITY reactivity|dep|reversal reactivity|nmod|END_ENTITY	Exaggerated coronary reactivity to endothelin-1 in diabetes : reversal with bosentan .
17322637	0	bosentan	10,18	endothelin-1	29,41	bosentan	endothelin-1	MESH:C086232	1906	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|concentration concentration|amod|END_ENTITY	Effect of bosentan on plasma endothelin-1 concentration in patients with pulmonary_arterial_hypertension .
19477379	0	bosentan	57,65	endothelin-1	32,44	bosentan	endothelin-1	MESH:C086232	1906	Chemical	Gene	administration|compound|START_ENTITY level|nmod|administration level|amod|END_ENTITY	Clinical significance of plasma endothelin-1 level after bosentan administration in pulmonary_arterial_hypertension .
20967148	0	bosentan	120,128	endothelin-1	19,31	bosentan	endothelin-1	MESH:C086232	24323(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY receptor|nmod|treatment receptor|nsubj|expression expression|nmod|END_ENTITY	Gene expression of endothelin-1 and endothelin receptor a on monocrotaline-induced pulmonary_hypertension in rats after bosentan treatment .
24071933	0	bosentan	91,99	endothelin-1	22,34	bosentan	endothelin-1	MESH:C086232	1906	Chemical	Gene	therapy|compound|START_ENTITY systemic_sclerosis|nmod|therapy patients|nmod|systemic_sclerosis Improvement|nmod|patients Improvement|nmod|plasma plasma|amod|END_ENTITY	Improvement of plasma endothelin-1 and nitric_oxide in patients with systemic_sclerosis by bosentan therapy .
24389822	0	bosentan	41,49	endothelin-1	8,20	bosentan	endothelin-1	MESH:C086232	24323(Tax:10116)	Chemical	Gene	receptor|nmod|START_ENTITY receptor|amod|END_ENTITY	Bladder endothelin-1 receptor binding of bosentan and ambrisentan .
26015909	0	bosentan	33,41	endothelin-1	8,20	bosentan	endothelin-1	MESH:C086232	24323(Tax:10116)	Chemical	Gene	Role|dep|START_ENTITY Role|nmod|antagonist antagonist|amod|END_ENTITY	Role of endothelin-1 antagonist ; bosentan , against cisplatin-induced nephrotoxicity in male and female rats .
7628480	0	bosentan	92,100	endothelin-1	48,60	bosentan	endothelin-1	MESH:C086232	1906	Chemical	Gene	START_ENTITY|nsubj|sites sites|nmod|END_ENTITY	Separable binding sites for the natural agonist endothelin-1 and the non-peptide antagonist bosentan on human endothelin-A receptors .
9016927	4	bosentan	1096,1104	endothelin-1	1139,1151	bosentan	endothelin-1	MESH:C086232	396915(Tax:9823)	Chemical	Gene	decreased|nsubj|START_ENTITY decreased|dobj|extraction extraction|nmod|END_ENTITY	In the lung , only bosentan decreased pulmonary extraction of endothelin-1 .
9110115	0	bosentan	80,88	endothelin-1	47,59	bosentan	endothelin-1	MESH:C086232	1906	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|antagonist antagonist|amod|END_ENTITY	Acute and short-term effects of the nonpeptide endothelin-1 receptor antagonist bosentan in humans .
9145775	0	bosentan	82,90	endothelin-1	45,57	bosentan	endothelin-1	MESH:C086232	1906	Chemical	Gene	effect|nmod|START_ENTITY Contraction|dep|effect Contraction|nmod|muscle muscle|nmod|END_ENTITY	Contraction of human airway smooth muscle by endothelin-1 and IRL_1620 : effect of bosentan .
22468718	0	bosentan	12,20	growth_factor	52,65	bosentan	growth factor	MESH:C086232	79215(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Relation of bosentan , iloprost , and sildenafil with growth_factor levels in monocrotaline-induced pulmonary_hypertension .
15811199	0	bosentan	14,22	matrix_metalloproteinase-9	26,52	bosentan	matrix metalloproteinase-9	MESH:C086232	4318	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|levels levels|amod|END_ENTITY	The effect of bosentan on matrix_metalloproteinase-9 levels in patients with systemic_sclerosis-induced pulmonary_hypertension .
25819335	0	boswellic_acid	50,64	VEGFR-2	87,94	boswellic acid	VEGFR-2	MESH:C054625	3791	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Synthesis and structure-activity relationships of boswellic_acid derivatives as potent VEGFR-2 inhibitors .
26711891	0	boswellic_acids	13,28	TNF-a	73,78	boswellic acids	TNF-a	null	7124	Chemical	Gene	Analogues|nmod|START_ENTITY Analogues|nmod|inhibitors inhibitors|nmod|END_ENTITY	Analogues of boswellic_acids as inhibitors of pro-inflammatory cytokines TNF-a and IL-6 .
19648270	0	boswellic_acids	62,77	cathepsin_G	24,35	boswellic acids	cathepsin G	null	1511	Chemical	Gene	target|nmod|START_ENTITY END_ENTITY|nmod|target	Identification of human cathepsin_G as a functional target of boswellic_acids from the anti-inflammatory remedy frankincense .
17945191	0	boswellic_acids	84,99	cyclooxygenase-1	42,58	boswellic acids	cyclooxygenase-1	null	5742	Chemical	Gene	START_ENTITY|nsubj|analysis analysis|nmod|END_ENTITY	Identification and functional analysis of cyclooxygenase-1 as a molecular target of boswellic_acids .
24512031	0	boswellic_acids	16,31	glucocorticoid_receptor	70,93	boswellic acids	glucocorticoid receptor	null	2908	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Interference of boswellic_acids with the ligand binding domain of the glucocorticoid_receptor .
10471408	0	bothrojaracin	72,85	thrombin	22,30	bothrojaracin	thrombin	MESH:C083739	2147	Chemical	Gene	interaction|nmod|START_ENTITY induced|nmod|interaction induced|nsubj|changes changes|nmod|site site|amod|END_ENTITY	Allosteric changes of thrombin catalytic site induced by interaction of bothrojaracin with anion-binding exosites I and II .
2557900	7	botrocetin	1158,1168	vWF	1178,1181	botrocetin	vWF	MESH:C030961	7450	Chemical	Gene	START_ENTITY|acl|bound bound|nmod|END_ENTITY	Binding studies with immobilized botrocetin demonstrated that botrocetin bound to vWF and to a 52/48-kDa region of vWF that contains the GP Ib binding domain , but not to glycocalicin , a proteolytic fragment of GP Ib that contains the vWF binding site .
21350424	0	botulotoxin	34,45	cramp	23,28	botulotoxin	cramp	null	820	Chemical	Gene	-RSB-|compound|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- Treatment of writer 's _ cramp with botulotoxin -RSB- .
25023142	0	bovine_folate	40,53	FOLR1	70,75	bovine folate	FOLR1	null	539750(Tax:9913)	Chemical	Gene	alpha|amod|START_ENTITY alpha|appos|END_ENTITY	Structural and dynamic investigation of bovine_folate receptor alpha -LRB- FOLR1 -RRB- , and role of ultra-high temperature processing on conformational and thermodynamic characteristics of FOLR1-folate complex .
11146451	0	bovine_lactoferrin	20,38	VEGF	61,65	bovine lactoferrin	VEGF	null	281572(Tax:9913)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Orally administered bovine_lactoferrin systemically inhibits VEGF -LRB- 165 -RRB- - mediated angiogenesis in the rat .
14687584	0	bovine_lactoferrin	20,38	caspase-1	47,56	bovine lactoferrin	caspase-1	null	514214(Tax:9913)	Chemical	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Orally administered bovine_lactoferrin induces caspase-1 and interleukin-18 in the mouse intestinal mucosa : a possible explanation for inhibition of carcinogenesis and metastasis .
18670097	0	bovine_lactoferrin	35,53	intelectin	18,28	bovine lactoferrin	intelectin	null	55600	Chemical	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Recombinant human intelectin binds bovine_lactoferrin and its peptides .
10409290	0	bradykinin	74,84	ACE	0,3	bradykinin	ACE	MESH:D001920	24310(Tax:10116)	Chemical	Gene	roles|nmod|START_ENTITY inhibition|dep|roles inhibition|compound|END_ENTITY	ACE inhibition and glucose transport in insulinresistant muscle : roles of bradykinin and nitric_oxide .
10567768	0	bradykinin	12,22	ACE	58,61	bradykinin	ACE	MESH:D001920	100009274(Tax:9986)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|inhibition inhibition|compound|END_ENTITY	The role of bradykinin in neonatal hemodynamic effects of ACE inhibition .
11849193	10	bradykinin	1514,1524	ACE	1588,1591	bradykinin	ACE	MESH:D001920	1636	Chemical	Gene	treated|nmod|START_ENTITY treated|nmod|inhibitor inhibitor|compound|END_ENTITY	CONCLUSIONS : Aspirin has no effect on the vasodilator response to bradykinin and substance_P in patients with heart_failure treated with an ACE inhibitor .
12131544	0	bradykinin	125,135	ACE	5,8	bradykinin	ACE	MESH:D001920	24310(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY prevents|nmod|receptor prevents|nsubj|END_ENTITY	Dual ACE and NEP inhibitor MDL-100 ,240 prevents and regresses severe angiotensin_II-dependent hypertension partially through bradykinin type 2 receptor .
12215475	0	bradykinin	64,74	ACE	0,3	bradykinin	ACE	MESH:D001920	11421(Tax:10090)	Chemical	Gene	mouse|nmod|START_ENTITY improves|nmod|mouse improves|nsubj|inhibitor inhibitor|compound|END_ENTITY	ACE inhibitor improves insulin resistance in diabetic mouse via bradykinin and NO .
1325885	0	bradykinin	124,134	ACE	106,109	bradykinin	ACE	MESH:D001920	24310(Tax:10116)	Chemical	Gene	hydrolysis|compound|START_ENTITY influence|nmod|hydrolysis Variation|dep|influence Variation|nmod|END_ENTITY	Variation in angiotensin-converting_enzyme -LRB- ACE -RRB- inhibitor affinity at two binding sites on rat pulmonary ACE : influence on bradykinin hydrolysis .
1325885	0	bradykinin	124,134	ACE	44,47	bradykinin	ACE	MESH:D001920	24310(Tax:10116)	Chemical	Gene	hydrolysis|compound|START_ENTITY influence|nmod|hydrolysis Variation|dep|influence Variation|nmod|sites sites|appos|END_ENTITY	Variation in angiotensin-converting_enzyme -LRB- ACE -RRB- inhibitor affinity at two binding sites on rat pulmonary ACE : influence on bradykinin hydrolysis .
1462857	0	bradykinin	24,34	ACE	0,3	bradykinin	ACE	MESH:D001920	100009274(Tax:9986)	Chemical	Gene	metabolism|compound|START_ENTITY inhibitor|nmod|metabolism inhibitor|nsubj|END_ENTITY	ACE inhibitor effect on bradykinin metabolism in the vascular wall .
15505492	0	bradykinin	103,113	ACE	60,63	bradykinin	ACE	MESH:D001920	11421(Tax:10090)	Chemical	Gene	nitric_oxide|xcomp|START_ENTITY nitric_oxide|dobj|effects effects|nmod|inhibitor inhibitor|compound|END_ENTITY	Endothelial nitric_oxide synthase-independent effects of an ACE inhibitor on coronary flow response to bradykinin in aged mice .
15680485	0	bradykinin	50,60	ACE	28,31	bradykinin	ACE	MESH:D001920	24310(Tax:10116)	Chemical	Gene	potentiation|compound|START_ENTITY inhibition|nmod|potentiation inhibition|compound|END_ENTITY	Role of PGI2 and effects of ACE inhibition on the bradykinin potentiation by angiotensin - -LRB- 1-7 -RRB- in resistance vessels of SHR .
20848272	0	bradykinin	121,131	ACE	49,52	bradykinin	ACE	MESH:D001920	100715217	Chemical	Gene	role|nmod|START_ENTITY Differences|dep|role Differences|nmod|inhibitors inhibitors|compound|END_ENTITY	Differences between zofenopril and ramipril , two ACE inhibitors , on cough induced by citric_acid in guinea_pigs : role of bradykinin and PGE2 .
26068694	0	bradykinin	75,85	ACE	24,27	bradykinin	ACE	MESH:D001920	1636	Chemical	Gene	antagonist|amod|START_ENTITY icatibant|appos|antagonist inhibitor-induced|nmod|icatibant inhibitor-induced|nsubj|treatment treatment|nmod|END_ENTITY	Successful treatment of ACE inhibitor-induced angioedema with icatibant , a bradykinin B2 receptor antagonist .
7545893	0	bradykinin	12,22	ACE	74,77	bradykinin	ACE	MESH:D001920	24310(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|action action|nmod|END_ENTITY	The role of bradykinin and nitric_oxide in the cardioprotective action of ACE inhibitors .
7749381	3	bradykinin	376,386	ACE	497,500	bradykinin	ACE	MESH:D001920	24310(Tax:10116)	Chemical	Gene	degrades|dobj|START_ENTITY proposed|advcl|degrades proposed|ccomp|represents represents|dobj|mechanism mechanism|acl:relcl|exert exert|nsubj|inhibitors inhibitors|compound|END_ENTITY	However , since ACE also degrades the potent endothelium-dependent vasodilator bradykinin , it has been proposed that the local accumulation of this peptide represents an additional mechanism by which ACE inhibitors exert their cardiovascular effects .
7858859	0	bradykinin	11,21	ACE	75,78	bradykinin	ACE	MESH:D001920	24310(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY Effects|nmod|receptor antagonism|nsubj|Effects antagonism|nmod|effects effects|nmod|inhibition inhibition|compound|END_ENTITY	Effects of bradykinin B2 receptor antagonism on the hypotensive effects of ACE inhibition .
8012702	0	bradykinin	58,68	ACE	16,19	bradykinin	ACE	MESH:D001920	100009274(Tax:9986)	Chemical	Gene	inhibitors|acl|START_ENTITY inhibitors|amod|Potentiation Potentiation|nmod|END_ENTITY	Potentiation by ACE inhibitors of the dilator response to bradykinin in the coronary microcirculation : interaction at the receptor level .
8856122	0	bradykinin	43,53	ACE	57,60	bradykinin	ACE	MESH:D001920	100009274(Tax:9986)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Potentiation of the biological efficacy of bradykinin by ACE inhibitors : a shift in the affinity of the B2 receptor ?
9331154	0	bradykinin	84,94	ACE	0,3	bradykinin	ACE	MESH:D001920	24310(Tax:10116)	Chemical	Gene	pathway|compound|START_ENTITY secretion|nmod|pathway stimulates|dobj|secretion stimulates|nsubj|inhibition inhibition|compound|END_ENTITY	ACE inhibition by enalaprilate stimulates duodenal mucosal alkaline secretion via a bradykinin pathway in the rat .
9350649	0	bradykinin	16,26	ACE	76,79	bradykinin	ACE	MESH:D001920	24310(Tax:10116)	Chemical	Gene	sites|compound|START_ENTITY Localization|nmod|sites Localization|nmod|treatment treatment|compound|END_ENTITY	Localization of bradykinin B2 binding sites in rat kidney following chronic ACE inhibitor treatment .
9622145	0	bradykinin	77,87	ACE	6,9	bradykinin	ACE	MESH:D001920	11421(Tax:10090)	Chemical	Gene	mediated|nmod|START_ENTITY mice|acl:relcl|mediated causes|nmod|mice causes|nsubj|inhibition inhibition|compound|END_ENTITY	Acute ACE inhibition causes plasma extravasation in mice that is mediated by bradykinin and substance_P .
9631877	0	bradykinin	129,139	ACE	62,65	bradykinin	ACE	MESH:D001920	24310(Tax:10116)	Chemical	Gene	roles|nmod|START_ENTITY kinase|nsubj|roles induced|parataxis|kinase induced|nmod|inhibition inhibition|compound|END_ENTITY	Mechanism of beta-adrenergic receptor upregulation induced by ACE inhibition in cultured neonatal rat cardiac myocytes : roles of bradykinin and protein kinase C. BACKGROUND : Although bradykinin is thought to contribute to the effects of ACE inhibitors on the cardiovascular system , its precise role remains to be elucidated .
9631877	0	bradykinin	183,193	ACE	62,65	bradykinin	ACE	MESH:D001920	24310(Tax:10116)	Chemical	Gene	thought|nsubjpass|START_ENTITY remains|advcl|thought induced|parataxis|remains induced|nmod|inhibition inhibition|compound|END_ENTITY	Mechanism of beta-adrenergic receptor upregulation induced by ACE inhibition in cultured neonatal rat cardiac myocytes : roles of bradykinin and protein kinase C. BACKGROUND : Although bradykinin is thought to contribute to the effects of ACE inhibitors on the cardiovascular system , its precise role remains to be elucidated .
11557571	0	bradykinin	21,31	ANG_II	11,17	bradykinin	ANG II	MESH:D001920	24179(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY Effects|nmod|expression Effects|nmod|END_ENTITY	Effects of ANG_II on bradykinin receptor gene expression in cardiomyocytes and vascular smooth muscle cells .
7621306	0	bradykinin	83,93	Angiotensin-converting_enzyme	0,29	bradykinin	Angiotensin-converting enzyme	MESH:D001920	24310(Tax:10116)	Chemical	Gene	inhibition|dep|START_ENTITY inhibition|amod|END_ENTITY	Angiotensin-converting_enzyme inhibition in infarct-induced heart_failure in rats : bradykinin versus angiotensin_II .
12014954	0	bradykinin	11,21	B2_receptor	142,153	bradykinin	B2 receptor	MESH:D001920	624	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|dep|conversion conversion|nmod|analogues analogues|nmod|antagonists antagonists|amod|END_ENTITY	Nonpeptide bradykinin B2_receptor antagonists : conversion of rodent-selective bradyzide analogues into potent , orally-active human bradykinin B2_receptor antagonists .
12014954	0	bradykinin	11,21	B2_receptor	22,33	bradykinin	B2 receptor	MESH:D001920	624	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|amod|END_ENTITY	Nonpeptide bradykinin B2_receptor antagonists : conversion of rodent-selective bradyzide analogues into potent , orally-active human bradykinin B2_receptor antagonists .
12014954	0	bradykinin	131,141	B2_receptor	142,153	bradykinin	B2 receptor	MESH:D001920	624	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|amod|END_ENTITY	Nonpeptide bradykinin B2_receptor antagonists : conversion of rodent-selective bradyzide analogues into potent , orally-active human bradykinin B2_receptor antagonists .
12014954	0	bradykinin	131,141	B2_receptor	22,33	bradykinin	B2 receptor	MESH:D001920	624	Chemical	Gene	antagonists|compound|START_ENTITY analogues|nmod|antagonists conversion|nmod|analogues antagonists|dep|conversion antagonists|amod|END_ENTITY	Nonpeptide bradykinin B2_receptor antagonists : conversion of rodent-selective bradyzide analogues into potent , orally-active human bradykinin B2_receptor antagonists .
14757160	0	bradykinin	118,128	B2_receptor	39,50	bradykinin	B2 receptor	MESH:D001920	624	Chemical	Gene	antagonists|compound|START_ENTITY pharmacophore|nmod|antagonists define|dobj|pharmacophore mutagenesis|acl|define mutagenesis|nmod|END_ENTITY	Site-directed mutagenesis at the human B2_receptor and molecular modelling to define the pharmacophore of non-peptide bradykinin receptor antagonists .
21786213	0	bradykinin	94,104	BK2R	116,120	bradykinin	BK2R	MESH:D001920	12062(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Abdominal_surgical_incision induces remote_preconditioning_of_trauma -LRB- RPCT -RRB- via activation of bradykinin receptors -LRB- BK2R -RRB- and the cytochrome P450 epoxygenase pathway in canine hearts .
9252484	0	bradykinin	24,34	CGRP	66,70	bradykinin	CGRP	MESH:D001920	24241(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	Lactic_acid potentiates bradykinin - and low-pH-induced release of CGRP from rat spinal cord slices .
9227696	0	bradykinin	21,31	CP-0597	0,7	bradykinin	CP-0597	MESH:D001920	963301(Tax:115711)	Chemical	Gene	antagonist|amod|START_ENTITY END_ENTITY|appos|antagonist	CP-0597 , a selective bradykinin B2 receptor antagonist , inhibits brain_injury in a rat model of reversible middle_cerebral_artery_occlusion .
9151726	0	bradykinin	115,125	Cdc42	37,42	bradykinin	Cdc42	MESH:D001920	12540(Tax:10090)	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	The monomeric G-proteins Rac1 and/or Cdc42 are required for the inhibition of voltage-dependent calcium current by bradykinin .
12675283	0	bradykinin	8,18	angiotensin_II_type_1_receptor_antagonist	48,89	bradykinin	angiotensin II type 1 receptor antagonist	MESH:D001920	24180(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of bradykinin in renoprotective effects by angiotensin_II_type_1_receptor_antagonist in salt-sensitive hypertension .
12669129	0	bradykinin	124,134	angiotensin_converting_enzyme	25,54	bradykinin	angiotensin converting enzyme	MESH:D001920	11421(Tax:10090)	Chemical	Gene	activation|amod|START_ENTITY mediated|nmod|activation mediated|nsubjpass|effect effect|nmod|inhibition inhibition|amod|END_ENTITY	The protective effect of angiotensin_converting_enzyme inhibition in experimental renal_fibrosis in mice is not mediated by bradykinin B2 receptor activation .
2540273	0	bradykinin	87,97	angiotensin_converting_enzyme	112,141	bradykinin	angiotensin converting enzyme	MESH:D001920	11421(Tax:10090)	Chemical	Gene	structure|nmod|START_ENTITY based|nmod|structure probe|acl|based Construction|nmod|probe Construction|dep|labelling labelling|nmod|END_ENTITY	Construction of a physiologically active photoaffinity probe based on the structure of bradykinin : labelling of angiotensin_converting_enzyme but not candidate bradykinin receptors on NG108-15 cells .
8866827	0	bradykinin	64,74	angiotensin_converting_enzyme	14,43	bradykinin	angiotensin converting enzyme	MESH:D001920	100715217	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of angiotensin_converting_enzyme and potentiation of bradykinin by retro-inverso analogues of short peptides and sequences related to angiotensin_I and bradykinin .
9450502	0	bradykinin	8,18	angiotensin_converting_enzyme	52,81	bradykinin	angiotensin converting enzyme	MESH:D001920	100009274(Tax:9986)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|inhibition inhibition|amod|END_ENTITY	Role of bradykinin in the neonatal renal effects of angiotensin_converting_enzyme inhibition .
9798525	0	bradykinin	164,174	angiotensin_converting_enzyme	33,62	bradykinin	angiotensin converting enzyme	MESH:D001920	24310(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY started|parataxis|role started|iobj|inhibition inhibition|amod|END_ENTITY	Chronic effects of early started angiotensin_converting_enzyme inhibition and angiotensin AT1-receptor subtype blockade in rats with myocardial_infarction : role of bradykinin .
19473241	0	bradykinin	99,109	calcitonin_gene-related_peptide	38,69	bradykinin	calcitonin gene-related peptide	MESH:D001920	12310(Tax:10090)	Chemical	Gene	heat-induced|nmod|START_ENTITY heat-induced|dobj|release release|amod|END_ENTITY	TRPV1 controls acid - and heat-induced calcitonin_gene-related_peptide release and sensitization by bradykinin in the isolated mouse trachea .
8478685	0	bradykinin	31,41	calcitonin_gene-related_peptide	86,117	bradykinin	calcitonin gene-related peptide	MESH:D001920	24241(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	Pharmacology of the effects of bradykinin , serotonin , and histamine on the release of calcitonin_gene-related_peptide from C-fiber terminals in the rat trachea .
8804084	0	bradykinin	56,66	calcitonin_gene-related_peptide	68,99	bradykinin	calcitonin gene-related peptide	MESH:D001920	24241(Tax:10116)	Chemical	Gene	CGRP|dep|START_ENTITY CGRP|amod|END_ENTITY	Proteases involved in the metabolism of angiotensin_II , bradykinin , calcitonin_gene-related_peptide -LRB- CGRP -RRB- , and neuropeptide_Y by vascular smooth muscle cells .
1341708	0	bradykinin	63,73	cathepsin_B	14,25	bradykinin	cathepsin B	MESH:D001920	64529(Tax:10116)	Chemical	Gene	involved|nmod|START_ENTITY involved|nsubj|Activation Activation|nmod|END_ENTITY	Activation of cathepsin_B involved in enkephalin production by bradykinin and its cleavage products in cultured fibroblasts of the rat dental pulp .
3301405	0	bradykinin	35,45	cathepsin_B	20,31	bradykinin	cathepsin B	MESH:D001920	64529(Tax:10116)	Chemical	Gene	Action|nmod|START_ENTITY Action|nmod|END_ENTITY	Action of rat liver cathepsin_B on bradykinin and on the oxidized insulin A-chain .
16580130	0	bradykinin	69,79	cyclooxygenase-2	141,157	bradykinin	cyclooxygenase-2	MESH:D001920	29527(Tax:10116)	Chemical	Gene	START_ENTITY|acl|induced induced|nmod|activation activation|nmod|END_ENTITY	The long-term exposure of rat cultured dorsal root ganglion cells to bradykinin induced the release of prostaglandin_E2 by the activation of cyclooxygenase-2 .
9422802	0	bradykinin	42,52	kininogen	13,22	bradykinin	kininogen	MESH:D001920	288001(Tax:10116)	Chemical	Gene	Synthesis|nmod|START_ENTITY Synthesis|nmod|END_ENTITY	Synthesis of kininogen and degradation of bradykinin by PC12 cells .
12639715	0	bradykinin	17,27	neurotensin	41,52	bradykinin	neurotensin	MESH:D001920	299757(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY Activation|nmod|receptors Activation|nmod|END_ENTITY	Activation of B2 bradykinin receptors by neurotensin .
2429002	0	bradykinin	15,25	substance_P	31,42	bradykinin	substance P	MESH:D001920	21333(Tax:10090)	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of bradykinin with substance_P on vascular permeability and pain response .
387773	0	bradykinin	95,105	thrombin	107,115	bradykinin	thrombin	MESH:D001920	14061(Tax:10090)	Chemical	Gene	serum|compound|START_ENTITY serum|dep|END_ENTITY	Specificity of phospholipases in methylcholanthrene-transformed mouse fibroblasts activated by bradykinin , thrombin , serum , and ionophore A23187 .
6127164	0	bradykinin	66,76	thrombin	50,58	bradykinin	thrombin	MESH:D001920	14061(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Regulation of prostaglandin synthesis mediated by thrombin and B2 bradykinin receptors in a fibrosarcoma cell line .
16024588	0	brassinolide	98,110	CYP85A2	12,19	brassinolide	CYP85A2	MESH:C023623	822709(Tax:3702)	Chemical	Gene	mediates|xcomp|START_ENTITY mediates|nsubj|END_ENTITY	Arabidopsis CYP85A2 , a cytochrome P450 , mediates the Baeyer-Villiger oxidation of castasterone to brassinolide in brassinosteroid biosynthesis .
12114546	0	brassinosteroid	92,107	BIN2	21,25	brassinosteroid	BIN2	CHEBI:22921	827605(Tax:3702)	Chemical	Gene	regulator|nmod|START_ENTITY BZR1|appos|regulator phosphorylates|dobj|BZR1 phosphorylates|nsubj|END_ENTITY	The GSK3-like kinase BIN2 phosphorylates and destabilizes BZR1 , a positive regulator of the brassinosteroid signaling pathway in Arabidopsis .
12427989	0	brassinosteroid	55,70	BIN2	13,17	brassinosteroid	BIN2	CHEBI:22921	853438(Tax:4932)	Chemical	Gene	signaling|amod|START_ENTITY components|nmod|signaling components|nsubj|substrates substrates|compound|END_ENTITY	Two putative BIN2 substrates are nuclear components of brassinosteroid signaling .
24164091	0	brassinosteroid	72,87	BIN2	47,51	brassinosteroid	BIN2	CHEBI:22921	827605(Tax:3702)	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Transcription factor HAT1 is phosphorylated by BIN2 kinase and mediates brassinosteroid repressed gene expression in Arabidopsis .
19124768	0	brassinosteroid	79,94	BRI1	32,36	brassinosteroid	BRI1	CHEBI:22921	830095(Tax:3702)	Chemical	Gene	component|nmod|START_ENTITY emerges|nmod|component emerges|nsubj|phosphorylation phosphorylation|nmod|kinase kinase|compound|END_ENTITY	Tyrosine phosphorylation of the BRI1 receptor kinase emerges as a component of brassinosteroid signaling in Arabidopsis .
19404750	0	brassinosteroid	11,26	BRI1	36,40	brassinosteroid	BRI1	CHEBI:22921	100736532	Chemical	Gene	START_ENTITY|dobj|receptor receptor|amod|binding binding|nmod:npmod|increases increases|nummod|END_ENTITY	The tomato brassinosteroid receptor BRI1 increases binding of systemin to tobacco plasma membranes , but is not involved in systemin signaling .
24488524	0	brassinosteroid	31,46	BRI1	65,69	brassinosteroid	BRI1	CHEBI:22921	830095(Tax:3702)	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Differential expression of the brassinosteroid receptor-encoding BRI1 gene in Arabidopsis .
11319239	0	brassinosteroid	96,111	cytochrome_P450_monooxygenase	59,88	brassinosteroid	cytochrome P450 monooxygenase	CHEBI:22921	57404	Chemical	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	Selective interaction of triazole derivatives with DWF4 , a cytochrome_P450_monooxygenase of the brassinosteroid biosynthetic pathway , correlates with brassinosteroid_deficiency in planta .
12729841	0	brazilin	96,104	nitric_oxide_synthase	50,71	brazilin	nitric oxide synthase	MESH:C044362	4843	Chemical	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	Induction of vasorelaxation through activation of nitric_oxide_synthase in endothelial cells by brazilin .
9395331	0	brefeldin_A	11,22	phospholipase_D	46,61	brefeldin A	phospholipase D	MESH:D020126	2822	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of brefeldin_A on phosphatidylcholine phospholipase_D and inositolphospholipid metabolism in HL-60 cells .
9541386	0	brinzolamide	90,102	carbonic_anhydrase_II	53,74	brinzolamide	carbonic anhydrase II	MESH:C111827	760	Chemical	Gene	complexed|nmod|START_ENTITY END_ENTITY|acl|complexed	Structures of murine carbonic_anhydrase_IV and human carbonic_anhydrase_II complexed with brinzolamide : molecular basis of isozyme-drug discrimination .
20103604	0	brivanib	51,59	vascular_endothelial_growth_factor	81,115	brivanib	vascular endothelial growth factor	MESH:C509922	7422	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	The antiangiogenic activity in xenograft models of brivanib , a dual inhibitor of vascular_endothelial_growth_factor receptor-2 and fibroblast_growth_factor_receptor-1 kinases .
3110820	0	brofaremine	11,22	MAO-A	93,98	brofaremine	MAO-A	null	4128	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|inhibitor inhibitor|nmod|END_ENTITY	Effects of brofaremine -LRB- CGP 11 305A -RRB- , a short-acting , reversible , and selective inhibitor of MAO-A on sleep , nocturnal penile tumescence and nocturnal hormonal secretion in three healthy volunteers .
2806381	0	brofaromine	30,41	MAO	15,18	brofaromine	MAO	MESH:C038213	29253(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	The reversible MAO inhibitor , brofaromine , inhibits serotonin uptake in vivo .
1418864	0	brofaromine	41,52	MAO-A	24,29	brofaromine	MAO-A	MESH:C038213	4128	Chemical	Gene	inhibitors|xcomp|START_ENTITY inhibitors|nsubj|Effect Effect|nmod|END_ENTITY	Effect of the selective MAO-A inhibitors brofaromine , clorgyline and moclobemide on human platelet MAO-B activity .
1638170	0	brofaromine	86,97	MAO-A	111,116	brofaromine	MAO-A	MESH:C038213	4128	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Psychopharmacological treatment of social_phobia : clinical and biochemical effects of brofaromine , a selective MAO-A inhibitor .
2677240	0	brofaromine	83,94	MAO-A	66,71	brofaromine	MAO-A	MESH:C038213	4128	Chemical	Gene	START_ENTITY|nsubj|profile profile|nmod|inhibitor inhibitor|amod|END_ENTITY	Therapeutic and side-effect profile of a selective and reversible MAO-A inhibitor , brofaromine .
7504824	0	brofaromine	44,55	MAO-A	18,23	brofaromine	MAO-A	MESH:C038213	4128	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|inhibitor inhibitor|amod|END_ENTITY	The effect of the MAO-A selective inhibitor brofaromine on the plasma and urine concentrations of some biogenic amines and their acidic metabolites in bulimia_nervosa .
7829762	0	brofaromine	67,78	MAO-A	103,108	brofaromine	MAO-A	MESH:C038213	4128	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	A Canadian multicentre placebo-controlled study of a fixed dose of brofaromine , a reversible selective MAO-A inhibitor , in the treatment of major_depression .
7865179	0	brofaromine	53,64	MAO-A	36,41	brofaromine	MAO-A	MESH:C038213	4128	Chemical	Gene	START_ENTITY|nsubj|inhibition inhibition|nmod|inhibitors inhibitors|amod|END_ENTITY	Monoamine oxidase inhibition by the MAO-A inhibitors brofaromine and clorgyline in healthy volunteers .
7931251	0	brofaromine	15,26	MAO-A	41,46	brofaromine	MAO-A	MESH:C038213	29253(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	The effects of brofaromine , a reversible MAO-A inhibitor , on extracellular serotonin in the raphe nuclei and frontal cortex of freely moving rats .
8430214	0	brofaromine	75,86	MAO-A	45,50	brofaromine	MAO-A	MESH:C038213	4128	Chemical	Gene	START_ENTITY|nsubj|aspects aspects|nmod|inhibitor inhibitor|nmod|reuptake reuptake|amod|END_ENTITY	Newer aspects of the reversible inhibitor of MAO-A and serotonin reuptake , brofaromine .
9829294	0	brofaromine	19,30	MAO-A	44,49	brofaromine	MAO-A	MESH:C038213	29253(Tax:10116)	Chemical	Gene	action|nmod|START_ENTITY END_ENTITY|nsubj|action	Regional action of brofaromine on rat brain MAO-A and MAO-B .
8776746	0	brofaromine	184,195	MAO_A	167,172	brofaromine	MAO A	MESH:C038213	4128	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Different modes of data processing and statistical testing applied to the same set of pharmaco-EEG recordings : effects on the evaluation of a selective and reversible MAO_A inhibitor -LRB- brofaromine -RRB- .
6152844	0	bromazepam	10,20	growth_hormone	24,38	bromazepam	growth hormone	MESH:D001960	2688	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of bromazepam on growth_hormone and prolactin secretion in normal subjects .
23474396	0	bromfenvinphos	14,28	acetylcholinesterase	68,88	bromfenvinphos	acetylcholinesterase	MESH:C014369	43	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|amod|END_ENTITY	The effect of bromfenvinphos , its impurities and chlorfenvinphos on acetylcholinesterase activity .
8482389	0	bromide	61,68	carbonic_anhydrase_II	23,44	bromide	carbonic anhydrase II	CHEBI:15858	760	Chemical	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	The structure of human carbonic_anhydrase_II in complex with bromide and azide .
24661847	0	bromides	61,69	cyclooxygenase-2	80,96	bromides	cyclooxygenase-2	MESH:D001965	5743	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Synthesis of thio-heterocyclic analogues from Baylis-Hillman bromides as potent cyclooxygenase-2 inhibitors .
14648180	0	bromocriptin	78,90	prolactin	166,175	bromocriptin	prolactin	MESH:D001971	5617	Chemical	Gene	trial|nmod|START_ENTITY trial|nmod|level level|compound|END_ENTITY	A prospective , double-blind , randomized , placebo-controlled clinical trial of bromocriptin in clomiphene-resistant patients with polycystic_ovary_syndrome and normal prolactin level .
229153	0	bromocriptine	18,31	ACTH	35,39	bromocriptine	ACTH	MESH:D001971	5443	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Lack of effect of bromocriptine on ACTH levels in patients with bilateral adrenalectomy for pituitary-dependent_Cushing 's _ syndrome .
6097444	0	bromocriptine	11,24	CRF	89,92	bromocriptine	CRF	MESH:D001971	1392	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of bromocriptine and cyproheptadine on basal and corticotropin-releasing_factor -LRB- CRF -RRB- - induced ACTH release in a patient with Nelson 's _ syndrome .
550290	0	bromocriptine	11,24	DBH	76,79	bromocriptine	DBH	MESH:D001971	1621	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	-LSB- Effect of bromocriptine on secretion of the enzyme dopamine-B-hydroxylase -LRB- DBH -RRB- in patients with Parkinson 's _ disease -RSB- .
3437376	0	bromocriptine	102,115	GH	49,51	bromocriptine	GH	MESH:D001971	2688	Chemical	Gene	administration|nmod|START_ENTITY study|nmod|administration regulation|dep|study regulation|nmod|secretion secretion|appos|END_ENTITY	Dopaminergic regulation of fetal growth_hormone -LRB- GH -RRB- secretion : study with maternal administration of bromocriptine .
6145276	0	bromocriptine	57,70	GH	18,20	bromocriptine	GH	MESH:D001971	2688	Chemical	Gene	therapy|amod|START_ENTITY END_ENTITY|nmod|therapy	Changes in plasma GH levels and clinical activity during bromocriptine therapy in acromegaly .
6441507	3	bromocriptine	329,342	GH	318,320	bromocriptine	GH	MESH:D001971	2688	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|nmod|patients patients|nmod|responses responses|nmod|END_ENTITY	In the 6 patients with inadequate responses of GH to TRH , bromocriptine inhibited this response .
7941955	0	bromocriptine	86,99	GH	65,67	bromocriptine	GH	MESH:D001971	2688	Chemical	Gene	administration|amod|START_ENTITY responses|nmod|administration responses|nmod|END_ENTITY	Neuroendocrine studies in dementia patients : responses of plasma GH and PRL following bromocriptine administration .
54702	0	bromocriptine	35,48	Growth-hormone	8,22	bromocriptine	Growth-hormone	MESH:D001971	2688	Chemical	Gene	response|acl|START_ENTITY response|amod|END_ENTITY	Letter : Growth-hormone response to bromocriptine in parkinsonism .
577473	0	bromocriptine	88,101	Growth_hormone	0,14	bromocriptine	Growth hormone	MESH:D001971	2688	Chemical	Gene	treatment|amod|START_ENTITY secretion|nmod|treatment END_ENTITY|acl|secretion	Growth_hormone , insulin , and prolactin secretion in anorexia_nervosa and obesity during bromocriptine treatment .
9509075	0	bromocriptine	144,157	Growth_hormone	0,14	bromocriptine	Growth hormone	MESH:D001971	2688	Chemical	Gene	therapy|amod|START_ENTITY elicited|nmod|therapy elicited|nsubj|secretion secretion|amod|END_ENTITY	Growth_hormone secretion elicited by GHRH , GHRP-6 or GHRH plus GHRP-6 in patients with microprolactinoma and macroprolactinoma before and after bromocriptine therapy .
3979799	0	bromocriptine	10,23	PTH	33,36	bromocriptine	PTH	MESH:D001971	24694(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|compound|END_ENTITY	Effect of bromocriptine on serum PTH , calcium and phosphate levels in azotemic rats .
16725868	0	bromocriptine	64,77	Prolactin	0,9	bromocriptine	Prolactin	MESH:D001971	5617	Chemical	Gene	treatment|amod|START_ENTITY secretion|nmod|treatment secretion|amod|END_ENTITY	Prolactin , progesterone and luteinizing hormone secretion after bromocriptine -LRB- CB-154 -RRB- treatment in cyclic sows .
1795298	0	bromocriptine	71,84	Prolactin	0,9	bromocriptine	Prolactin	MESH:D001971	5617	Chemical	Gene	lactating|nmod|START_ENTITY secretion|advcl|lactating secretion|nsubj|END_ENTITY	Prolactin secretion in lactating mares before and after treatment with bromocriptine .
2744187	0	bromocriptine	25,38	Prolactin	0,9	bromocriptine	Prolactin	MESH:D001971	5617	Chemical	Gene	suppression|nmod|START_ENTITY suppression|compound|END_ENTITY	Prolactin suppression by bromocriptine stimulates aromatization of testosterone to estradiol in women .
3336541	0	bromocriptine	63,76	Prolactin	0,9	bromocriptine	Prolactin	MESH:D001971	5617	Chemical	Gene	lisuride|compound|START_ENTITY patterns|nmod|lisuride tests|dep|patterns tests|amod|END_ENTITY	Prolactin stimulation tests : different response patterns after bromocriptine , lisuride , and metergoline treatment of puerperal women .
3653413	0	bromocriptine	59,72	Prolactin	0,9	bromocriptine	Prolactin	MESH:D001971	5617	Chemical	Gene	treatment|compound|START_ENTITY function|nmod|treatment function|nsubj|secretion secretion|compound|END_ENTITY	Prolactin secretion and menstrual function after long-term bromocriptine treatment .
589073	0	bromocriptine	74,87	Prolactin	0,9	bromocriptine	Prolactin	MESH:D001971	5617	Chemical	Gene	treatment|nmod|START_ENTITY concentrations|dep|treatment concentrations|compound|END_ENTITY	Prolactin concentrations in ovulatory but infertile women : treatment with bromocriptine .
8177009	0	bromocriptine	26,39	Prolactin	0,9	bromocriptine	Prolactin	MESH:D001971	396965(Tax:9823)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|END_ENTITY	Prolactin secretion after bromocriptine in the hypophysial stalk-transfected gilt .
819453	0	bromocriptine	122,135	Prolactin	0,9	bromocriptine	Prolactin	MESH:D001971	5617	Chemical	Gene	effect|nmod|START_ENTITY responses|dep|effect responses|compound|END_ENTITY	Prolactin and thyrotropin responses to thyrotropin-releasing_hormone in patients with secondary amenorrhea : the effect of bromocriptine .
9197946	0	bromocriptine	22,35	Prolactin	0,9	bromocriptine	Prolactin	MESH:D001971	5617	Chemical	Gene	START_ENTITY|nsubj|response response|compound|END_ENTITY	Prolactin response to bromocriptine in flunarizine-treated migrainous women .
3096783	0	bromocriptine	98,111	Thyrotropin-releasing_hormone	0,29	bromocriptine	Thyrotropin-releasing hormone	MESH:D001971	7200	Chemical	Gene	therapy|amod|START_ENTITY effectiveness|nmod|therapy predict|dobj|effectiveness test|xcomp|predict test|nsubj|END_ENTITY	Thyrotropin-releasing_hormone and gonadotropin-releasing_hormone test to predict effectiveness of bromocriptine therapy in infertile women .
2499727	0	bromocriptine	11,24	cytochrome_P-450	36,52	bromocriptine	cytochrome P-450	MESH:D001971	25251(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|system system|amod|END_ENTITY	Effects of bromocriptine on hepatic cytochrome_P-450 monooxygenase system .
550290	0	bromocriptine	11,24	dopamine-B-hydroxylase	52,74	bromocriptine	dopamine-B-hydroxylase	MESH:D001971	1621	Chemical	Gene	START_ENTITY|nmod|secretion secretion|nmod|END_ENTITY	-LSB- Effect of bromocriptine on secretion of the enzyme dopamine-B-hydroxylase -LRB- DBH -RRB- in patients with Parkinson 's _ disease -RSB- .
102468	0	bromocriptine	79,92	growth_hormone	6,20	bromocriptine	growth hormone	MESH:D001971	2688	Chemical	Gene	tissue|nmod|START_ENTITY END_ENTITY|nmod|tissue	Serum growth_hormone and ultrastructural studies of adenohypophysial tissue in bromocriptine treated acromegalic patients .
114344	0	bromocriptine	17,30	growth_hormone	50,64	bromocriptine	growth hormone	MESH:D001971	2688	Chemical	Gene	influence|nmod|START_ENTITY influence|nmod|levels levels|nmod|hormones hormones|compound|END_ENTITY	The influence of bromocriptine on serum levels of growth_hormone and other pituitary hormones and its metabolic effects in active acromegaly .
1789059	0	bromocriptine	45,58	growth_hormone	92,106	bromocriptine	growth hormone	MESH:D001971	2688	Chemical	Gene	drugs|amod|START_ENTITY effects|nmod|drugs Dynamics|nmod|effects Dynamics|nmod|secretion secretion|amod|END_ENTITY	Dynamics of the acute effects of octreotide , bromocriptine and both drugs in combination on growth_hormone secretion in acromegaly .
18559918	0	bromocriptine	26,39	growth_hormone	68,82	bromocriptine	growth hormone	MESH:D001971	2688	Chemical	Gene	treatment|nmod|START_ENTITY improves|nsubj|treatment improves|dobj|secretion secretion|compound|END_ENTITY	Short-term treatment with bromocriptine improves impaired circadian growth_hormone secretion in obese premenopausal women .
1973122	0	bromocriptine	91,104	growth_hormone	40,54	bromocriptine	growth hormone	MESH:D001971	2688	Chemical	Gene	analogue|amod|START_ENTITY comparison|nmod|analogue comparison|nmod|effectiveness effectiveness|nmod|suppression suppression|amod|END_ENTITY	A comparison among the effectiveness of growth_hormone suppression in active acromegaly of bromocriptine and long acting somatostatin analogue -LRB- SMS_201-995 -RRB- .
2520459	0	bromocriptine	44,57	growth_hormone	69,83	bromocriptine	growth hormone	MESH:D001971	2688	Chemical	Gene	START_ENTITY|nmod|morphology morphology|amod|END_ENTITY	In vitro short-term effects of SMS 201-995 , bromocriptine and TRH on growth_hormone cell morphology from human pituitary_adenomas .
2888694	0	bromocriptine	31,44	growth_hormone	65,79	bromocriptine	growth hormone	MESH:D001971	81668(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	A comparison of the effects of bromocriptine and somatostatin on growth_hormone gene expression in the rat anterior pituitary gland in vitro .
3082095	0	bromocriptine	73,86	growth_hormone	55,69	bromocriptine	growth hormone	MESH:D001971	2688	Chemical	Gene	unresponsive|amod|START_ENTITY acromegaly|amod|unresponsive END_ENTITY|nmod|acromegaly	No effect of treatment with sodium_valproate on plasma growth_hormone in bromocriptine unresponsive acromegaly .
3115634	0	bromocriptine	101,114	growth_hormone	15,29	bromocriptine	growth hormone	MESH:D001971	2688	Chemical	Gene	response|nmod|START_ENTITY releasing|nsubj|response releasing|advcl|growth_hormone_releasing_hormone growth_hormone_releasing_hormone|nsubj|response response|amod|END_ENTITY	The higher the growth_hormone response to growth_hormone_releasing_hormone the lower the response to bromocriptine and thyrotrophin releasing hormone in acromegaly .
3226523	0	bromocriptine	39,52	growth_hormone	78,92	bromocriptine	growth hormone	MESH:D001971	2688	Chemical	Gene	test|amod|START_ENTITY manifested|nmod|test manifested|nmod|adenoma adenoma|amod|END_ENTITY	Pituitary apoplexy manifested during a bromocriptine test in a patient with a growth_hormone - and prolactin-producing pituitary adenoma .
3437376	0	bromocriptine	102,115	growth_hormone	33,47	bromocriptine	growth hormone	MESH:D001971	2688	Chemical	Gene	administration|nmod|START_ENTITY study|nmod|administration regulation|dep|study regulation|nmod|secretion secretion|amod|END_ENTITY	Dopaminergic regulation of fetal growth_hormone -LRB- GH -RRB- secretion : study with maternal administration of bromocriptine .
3923021	0	bromocriptine	63,76	growth_hormone	23,37	bromocriptine	growth hormone	MESH:D001971	2688	Chemical	Gene	GH/prolactin-containing|amod|START_ENTITY GH/prolactin-containing|amod|END_ENTITY	Different responses of growth_hormone secretion to guanfacine , bromocriptine , and thyrotropin-releasing_hormone in acromegalic patients with pure growth_hormone -LRB- GH -RRB- - containing and mixed GH/prolactin-containing pituitary_adenomas .
422709	0	bromocriptine	43,56	growth_hormone	79,93	bromocriptine	growth hormone	MESH:D001971	2688	Chemical	Gene	treatment|amod|START_ENTITY woman|nmod|treatment pregnancy|nmod|woman pregnancy|dep|effects effects|nmod|END_ENTITY	A pregnancy in an acromegalic woman during bromocriptine treatment : effects on growth_hormone and prolactin in the maternal , fetal , and amniotic compartments .
488905	0	bromocriptine	71,84	growth_hormone	32,46	bromocriptine	growth hormone	MESH:D001971	2688	Chemical	Gene	administration|amod|START_ENTITY acromegaly|nmod|administration END_ENTITY|nmod|acromegaly	Gel filtration studies of serum growth_hormone in acromegaly following bromocriptine administration .
534183	0	bromocriptine	99,112	growth_hormone	30,44	bromocriptine	growth hormone	MESH:D001971	2688	Chemical	Gene	-RSB-|amod|START_ENTITY treated|nmod|-RSB- treated|nsubj|variations variations|nmod|END_ENTITY	-LSB- Nycterohemeral variations of growth_hormone and prolactin in 6 Parkinson 's _ sufferers treated with bromocriptine -LRB- author 's transl -RRB- -RSB- .
6310918	0	bromocriptine	50,63	growth_hormone	67,81	bromocriptine	growth hormone	MESH:D001971	2688	Chemical	Gene	action|nmod|START_ENTITY role|nmod|action role|nmod|secretion secretion|amod|END_ENTITY	The role of prolactin in the inhibitory action of bromocriptine on growth_hormone secretion in acromegaly .
6427255	2	bromocriptine	61,74	growth_hormone	78,92	bromocriptine	growth hormone	MESH:D001971	2688	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|amod|END_ENTITY	Effects of bromocriptine on growth_hormone secretion and adult height prediction .
6727657	0	bromocriptine	11,24	growth_hormone	75,89	bromocriptine	growth hormone	MESH:D001971	2688	Chemical	Gene	Failure|nmod|START_ENTITY Failure|acl|alter alter|dobj|characteristics characteristics|nmod|END_ENTITY	Failure of bromocriptine to alter the qualitative characteristics of human growth_hormone in acromegaly .
6744634	0	bromocriptine	44,57	growth_hormone	7,21	bromocriptine	growth hormone	MESH:D001971	2688	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|dobj|effect	Plasma growth_hormone suppressive effect of bromocriptine in acromegaly .
6807686	0	bromocriptine	108,121	growth_hormone	80,94	bromocriptine	growth hormone	MESH:D001971	2688	Chemical	Gene	secretion|xcomp|START_ENTITY secretion|nsubj|value value|nmod|levels levels|nmod|prediction prediction|nmod|responsiveness responsiveness|nmod|END_ENTITY	The value of plasma prolactin levels in the prediction of the responsiveness of growth_hormone secretion to bromocriptine and TRH in acromegaly .
7285875	0	bromocriptine	10,23	growth_hormone	51,65	bromocriptine	growth hormone	MESH:D001971	81668(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY hormone-induced|nsubj|Effect hormone-induced|dobj|production production|amod|END_ENTITY	Effect of bromocriptine on thyroid hormone-induced growth_hormone production in cultured GH1 cells .
7680832	0	bromocriptine	35,48	growth_hormone	56,70	bromocriptine	growth hormone	MESH:D001971	2688	Chemical	Gene	START_ENTITY|nmod|response response|amod|END_ENTITY	Effect of long-term treatment with bromocriptine on the growth_hormone response to galanin in patients with acromegaly .
26060825	2	bromocriptine	331,344	insulin	247,254	bromocriptine	insulin	MESH:D001971	3630	Chemical	Gene	formulation|nmod|START_ENTITY use|appos|formulation use|nmod|agent agent|compound|END_ENTITY	The concurrent use of a postprandial insulin sensitizing agent , such as bromocriptine-QR , a quick release formulation of bromocriptine , a dopamine_D2_receptor agonist , may offer a strategy to improve glycemic control and limit/reduce insulin requirement in type 2 diabetes -LRB- T2DM -RRB- patients on high-dose insulin .
7035013	0	bromocriptine	14,27	insulin	31,38	bromocriptine	insulin	MESH:D001971	3630	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|compound|END_ENTITY	The effect of bromocriptine on insulin secretion and glucose tolerance in patients with acromegaly .
7037921	0	bromocriptine	71,84	insulin	32,39	bromocriptine	insulin	MESH:D001971	3630	Chemical	Gene	study|nmod|START_ENTITY control|dep|study control|nmod|secretion secretion|compound|END_ENTITY	Neuroendocrine control of basal insulin secretion in man : a study with bromocriptine , clonidine and naloxone .
574831	0	bromocriptine	10,23	ornithine_decarboxylase	35,58	bromocriptine	ornithine decarboxylase	MESH:D001971	4953	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of bromocriptine on gonadal ornithine_decarboxylase in vitro .
11006160	0	bromocriptine	11,24	prolactin	93,102	bromocriptine	prolactin	MESH:D001971	443317(Tax:9940)	Chemical	Gene	administration|amod|START_ENTITY Effects|nmod|administration Effects|nmod|phase phase|nmod|cycle cycle|nmod|secretion secretion|compound|END_ENTITY	Effects of bromocriptine administration during the follicular phase of the oestrous cycle on prolactin and gonadotrophin secretion and follicular dynamics in merino monovular ewes .
1101946	0	bromocriptine	10,23	prolactin	82,91	bromocriptine	prolactin	MESH:D001971	5617	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of bromocriptine and chlorotrianisene on inhibition of lactation and serum prolactin .
12570169	0	bromocriptine	78,91	prolactin	167,176	bromocriptine	prolactin	MESH:D001971	5617	Chemical	Gene	trial|nmod|START_ENTITY trial|nmod|level level|compound|END_ENTITY	A prospective , double-blind , randomized , placebo-controlled clinical trial of bromocriptine in clomiphene-resistant patients with polycystic_ovary_syndrome and normal prolactin level .
12824819	0	bromocriptine	127,140	prolactin	144,153	bromocriptine	prolactin	MESH:D001971	5617	Chemical	Gene	action|nmod|START_ENTITY abolish|dobj|action abolish|nmod|release release|compound|END_ENTITY	Ethanol and estradiol modulate alternative splicing of dopamine_D2_receptor messenger RNA and abolish the inhibitory action of bromocriptine on prolactin release from the pituitary gland .
1796748	0	bromocriptine	33,46	prolactin	103,112	bromocriptine	prolactin	MESH:D001971	5617	Chemical	Gene	preparations|compound|START_ENTITY preparations|dep|comparison comparison|nmod|END_ENTITY	Oral and injectable long-lasting bromocriptine preparations in hyperprolactinemia : comparison of their prolactin lowering activity , tolerability and safety .
1806471	0	bromocriptine	47,60	prolactin	103,112	bromocriptine	prolactin	MESH:D001971	5617	Chemical	Gene	START_ENTITY|dobj|therapy therapy|nmod|levels levels|compound|END_ENTITY	A_giant_prolactinoma and the effect of chronic bromocriptine therapy on basal and TRH-stimulated serum prolactin levels .
1859183	0	bromocriptine	109,122	prolactin	12,21	bromocriptine	prolactin	MESH:D001971	24683(Tax:10116)	Chemical	Gene	experimental_allergic_encephalomyelitis|nmod|START_ENTITY suppression|nmod|experimental_allergic_encephalomyelitis role|dep|suppression role|nmod|END_ENTITY	The role of prolactin in autoimmune demyelination : suppression of experimental_allergic_encephalomyelitis by bromocriptine .
21324816	0	bromocriptine	31,44	prolactin	9,18	bromocriptine	prolactin	MESH:D001971	5617	Chemical	Gene	response|dep|START_ENTITY response|compound|END_ENTITY	Positive prolactin response to bromocriptine in 2 patients with cabergoline-resistant prolactinomas .
2168264	0	bromocriptine	86,99	prolactin	16,25	bromocriptine	prolactin	MESH:D001971	5617	Chemical	Gene	dissociated|advcl|START_ENTITY pituitary_tumor|acl|dissociated END_ENTITY|dep|pituitary_tumor	Thyrotropin-and prolactin -- secreting pituitary_tumor dissociated hormonal response to bromocriptine .
2507095	0	bromocriptine	11,24	prolactin	57,66	bromocriptine	prolactin	MESH:D001971	24683(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY combined|nsubj|Effect combined|nmod|END_ENTITY	-LSB- Effect of bromocriptine and bromocriptine combined with prolactin on the proliferation of thymocytes in young rats -RSB- .
2706805	0	bromocriptine	60,73	prolactin	37,46	bromocriptine	prolactin	MESH:D001971	24683(Tax:10116)	Chemical	Gene	Blood|advcl|START_ENTITY Blood|dobj|responses responses|compound|END_ENTITY	Blood pressure , plasma and pituitary prolactin responses to bromocriptine in New Zealand genetically hypertensive and normotensive rats .
3171464	0	bromocriptine	88,101	prolactin	105,114	bromocriptine	prolactin	MESH:D001971	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Quantitative in-situ hybridization histochemistry in the rat pituitary gland : effect of bromocriptine on prolactin and pro-opiomelanocortin gene expression .
3173919	0	bromocriptine	8,21	prolactin	56,65	bromocriptine	prolactin	MESH:D001971	5617	Chemical	Gene	START_ENTITY|dep|pharmacology pharmacology|nmod|END_ENTITY	Vaginal bromocriptine : pharmacology and effect on serum prolactin in normal women .
3220463	0	bromocriptine	10,23	prolactin	61,70	bromocriptine	prolactin	MESH:D001971	5617	Chemical	Gene	START_ENTITY|nmod|secretion secretion|nmod|cell cell|compound|END_ENTITY	Effect of bromocriptine on secretion and morphology of human prolactin cell adenomas in vitro .
3224440	0	bromocriptine	77,90	prolactin	37,46	bromocriptine	prolactin	MESH:D001971	24683(Tax:10116)	Chemical	Gene	Blood|xcomp|START_ENTITY Blood|dobj|levels levels|compound|END_ENTITY	Blood pressure , plasma and pituitary prolactin levels and their responses to bromocriptine in the segregating F2 generation of the SHR/WKY hybrid .
3345193	0	bromocriptine	36,49	prolactin	53,62	bromocriptine	prolactin	MESH:D001971	751517(Tax:9685)	Chemical	Gene	effects|nmod|START_ENTITY Antagonism|nmod|effects Antagonism|nmod|END_ENTITY	Antagonism of behavioral effects of bromocriptine by prolactin in female cats .
3383612	0	bromocriptine	82,95	prolactin	12,21	bromocriptine	prolactin	MESH:D001971	5617	Chemical	Gene	hyperprolactinaemia|nmod|START_ENTITY treatment|nmod|hyperprolactinaemia role|dep|treatment role|nmod|END_ENTITY	The role of prolactin in luteal inadequacy : treatment of hyperprolactinaemia with bromocriptine .
3404163	0	bromocriptine	10,23	prolactin	52,61	bromocriptine	prolactin	MESH:D001971	5617	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|compound|END_ENTITY	Effect of bromocriptine and metoclopramide on serum prolactin levels in patients with amyotrophic_lateral_sclerosis .
361149	0	bromocriptine	48,61	prolactin	28,37	bromocriptine	prolactin	MESH:D001971	5617	Chemical	Gene	START_ENTITY|nsubj|trial trial|nmod|inhibitor inhibitor|compound|END_ENTITY	A double blind trial of the prolactin inhibitor bromocriptine in painful benign_breast_disease .
3625096	0	bromocriptine	13,26	prolactin	44,53	bromocriptine	prolactin	MESH:D001971	24683(Tax:10116)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|growth growth|amod|END_ENTITY	Influence of bromocriptine and oestrogen on prolactin synthesis , secretion and tumour growth in vivo in rats .
3716756	0	bromocriptine	69,82	prolactin	13,22	bromocriptine	prolactin	MESH:D001971	5617	Chemical	Gene	decreased|nmod|START_ENTITY decreased|nsubjpass|Human Human|dep|END_ENTITY	Human foetal prolactin but not thyrotropin secretion is decreased by bromocriptine .
3755462	0	bromocriptine	83,96	prolactin	42,51	bromocriptine	prolactin	MESH:D001971	5617	Chemical	Gene	Effects|acl|START_ENTITY Effects|nmod|lactation lactation|nmod|concentrations concentrations|compound|END_ENTITY	Effects of lactation and season on plasma prolactin concentrations and response to bromocriptine during lactation in the Bennett 's wallaby -LRB- Macropus rufogriseus rufogriseus -RRB- .
3776529	0	bromocriptine	98,111	prolactin	32,41	bromocriptine	prolactin	MESH:D001971	5617	Chemical	Gene	treatment|amod|START_ENTITY localization|nmod|treatment localization|nmod|END_ENTITY	Ultrastructural localization of prolactin in the human pituitary_prolactinomas and its changes by bromocriptine treatment .
3905210	0	bromocriptine	10,23	prolactin	37,46	bromocriptine	prolactin	MESH:D001971	5617	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|END_ENTITY	Effect of bromocriptine treatment on prolactin , noradrenaline and blood pressure in hypertensive haemodialysis patients .
3925360	0	bromocriptine	58,71	prolactin	185,194	bromocriptine	prolactin	MESH:D001971	24683(Tax:10116)	Chemical	Gene	decreases|compound|START_ENTITY induced|nmod|decreases Hypoprolactinemia|acl|induced tuberoinfundibular|nsubj|Hypoprolactinemia tuberoinfundibular|nmod|END_ENTITY	Hypoprolactinemia induced by hypophysectomy and long-term bromocriptine treatment decreases tuberoinfundibular dopaminergic neuronal activity and the responsiveness of these neurons to prolactin .
3927887	0	bromocriptine	10,23	prolactin	70,79	bromocriptine	prolactin	MESH:D001971	5617	Chemical	Gene	therapy|compound|START_ENTITY restore|nsubj|therapy restore|dobj|control control|nmod|release release|compound|END_ENTITY	Long-term bromocriptine therapy may restore the inhibitory control of prolactin release in some patients with pathological hyperprolactinemia .
3956565	0	bromocriptine	34,47	prolactin	103,112	bromocriptine	prolactin	MESH:D001971	5617	Chemical	Gene	preparation|compound|START_ENTITY Pharmacokinetics|nmod|preparation Pharmacokinetics|nmod|hormone hormone|compound|END_ENTITY	Pharmacokinetics of a long-acting bromocriptine preparation -LRB- Parlodel LA -RRB- and its effect on release of prolactin and growth hormone .
4083636	0	bromocriptine	12,25	prolactin	57,66	bromocriptine	prolactin	MESH:D001971	5617	Chemical	Gene	treatment|amod|START_ENTITY Results|nmod|treatment Results|nmod|adenomas adenomas|compound|END_ENTITY	-LSB- Results of bromocriptine treatment of giant or invasive prolactin adenomas .
528777	0	bromocriptine	13,26	prolactin	47,56	bromocriptine	prolactin	MESH:D001971	5617	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|levels levels|nmod|hormones hormones|compound|END_ENTITY	Influence of bromocriptine on plasma levels of prolactin and steroid hormones in the 20th week of pregnancy .
574700	0	bromocriptine	77,90	prolactin	26,35	bromocriptine	prolactin	MESH:D001971	5617	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|suppression suppression|nmod|END_ENTITY	Persisting suppression of prolactin secretion after long-term treatment with bromocriptine in patients with prolactinomas .
6111093	0	bromocriptine	32,45	prolactin	92,101	bromocriptine	prolactin	MESH:D001971	5617	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|levels levels|compound|END_ENTITY	-LSB- Effect of high single doses of bromocriptine in schizophrenic patients with elevated serum prolactin levels and extrapyramidal side effects associated with neuroleptic treatment -LRB- author 's transl -RRB- -RSB- .
6170968	0	bromocriptine	57,70	prolactin	27,36	bromocriptine	prolactin	MESH:D001971	5617	Chemical	Gene	lowering|nmod|START_ENTITY aspects|acl|lowering aspects|nmod|END_ENTITY	Circadian aspects of serum prolactin and TSH lowering by bromocriptine in patients with prostatic_hypertrophy .
6214512	0	bromocriptine	34,47	prolactin	10,19	bromocriptine	prolactin	MESH:D001971	24683(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|Effect Effect|nmod|END_ENTITY	Effect of prolactin inhibition by bromocriptine on testicular metabolism in the adult rat .
6310918	0	bromocriptine	50,63	prolactin	12,21	bromocriptine	prolactin	MESH:D001971	5617	Chemical	Gene	action|nmod|START_ENTITY role|nmod|action role|nmod|END_ENTITY	The role of prolactin in the inhibitory action of bromocriptine on growth_hormone secretion in acromegaly .
6420492	0	bromocriptine	11,24	prolactin	58,67	bromocriptine	prolactin	MESH:D001971	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|levels levels|nmod|END_ENTITY	Effects of bromocriptine and naloxone on plasma levels of prolactin , LH and FSH during suckling in the female rat : responses to gonadotrophin releasing hormone .
6434437	0	bromocriptine	44,57	prolactin	80,89	bromocriptine	prolactin	MESH:D001971	24683(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of treatment with different doses of bromocriptine on plasma profiles of prolactin , gonadotrophins and testosterone in mature male rats and mice .
6538517	0	bromocriptine	65,78	prolactin	13,22	bromocriptine	prolactin	MESH:D001971	5617	Chemical	Gene	value|nmod|START_ENTITY value|nmod|dynamics dynamics|compound|END_ENTITY	The value of prolactin dynamics as a predictor of ovulation with bromocriptine in patients with polycystic_ovary_syndrome .
6682397	0	bromocriptine	109,122	prolactin	8,17	bromocriptine	prolactin	MESH:D001971	5617	Chemical	Gene	studied|nmod|START_ENTITY studied|nsubj|Role Role|nmod|END_ENTITY	Role of prolactin in human milk composition and serum lipids studied during suppression of galactorrhea with bromocriptine .
6704349	0	bromocriptine	115,128	prolactin	6,15	bromocriptine	prolactin	MESH:D001971	5617	Chemical	Gene	study|nmod|START_ENTITY END_ENTITY|dep|study	Serum prolactin and ovarian function after discontinuation of drug treatment for hyperprolactinaemia : a study with bromocriptine and metergoline .
6779003	0	bromocriptine	45,58	prolactin	87,96	bromocriptine	prolactin	MESH:D001971	443317(Tax:9940)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of removal of lambs or treatment with bromocriptine on plasma concentrations of prolactin and FSH during the post-partum period in ewes lambing at different times during the breeding season .
6807686	0	bromocriptine	108,121	prolactin	20,29	bromocriptine	prolactin	MESH:D001971	5617	Chemical	Gene	secretion|xcomp|START_ENTITY secretion|nsubj|value value|nmod|levels levels|compound|END_ENTITY	The value of plasma prolactin levels in the prediction of the responsiveness of growth_hormone secretion to bromocriptine and TRH in acromegaly .
7006588	0	bromocriptine	18,31	prolactin	89,98	bromocriptine	prolactin	MESH:D001971	5617	Chemical	Gene	Lack|nmod|START_ENTITY Lack|nmod|quality quality|nmod|men men|nmod|levels levels|compound|END_ENTITY	Lack of effect of bromocriptine on semen quality in men with normal or slightly elevated prolactin levels .
7105430	0	bromocriptine	62,75	prolactin	29,38	bromocriptine	prolactin	MESH:D001971	5617	Chemical	Gene	treatment|compound|START_ENTITY Menstrual|nmod|treatment Menstrual|dobj|levels levels|compound|END_ENTITY	Menstrual function and serum prolactin levels after long-term bromocriptine treatment of hyperprolactinaemic amenorrhoea .
7270010	0	bromocriptine	21,34	prolactin	63,72	bromocriptine	prolactin	MESH:D001971	5617	Chemical	Gene	treatment|compound|START_ENTITY Effect|nmod|treatment Effect|nmod|concentration concentration|compound|END_ENTITY	Effect of short-term bromocriptine treatment on amniotic fluid prolactin concentration in the first half of pregnancy .
7315128	0	bromocriptine	54,67	prolactin	15,24	bromocriptine	prolactin	MESH:D001971	5617	Chemical	Gene	weeks|nmod|START_ENTITY Suppression|nmod|weeks Suppression|nmod|macroadenoma macroadenoma|compound|END_ENTITY	Suppression of prolactin macroadenoma in 8 weeks with bromocriptine .
7320436	0	bromocriptine	81,94	prolactin	25,34	bromocriptine	prolactin	MESH:D001971	5617	Chemical	Gene	treatment|amod|START_ENTITY changes|nmod|treatment rhythmicity|dep|changes rhythmicity|nmod|secretion secretion|compound|END_ENTITY	Circadian rhythmicity of prolactin secretion in elderly subjects : changes during bromocriptine treatment .
7460836	0	bromocriptine	99,112	prolactin	46,55	bromocriptine	prolactin	MESH:D001971	24683(Tax:10116)	Chemical	Gene	formation|nmod|START_ENTITY prevention|nmod|formation Relationship|dep|prevention Relationship|nmod|induction induction|nmod|secretion secretion|compound|END_ENTITY	Relationship of polycystic ovary induction to prolactin secretion : prevention of cyst formation by bromocriptine in the rat .
8116455	0	bromocriptine	62,75	prolactin	95,104	bromocriptine	prolactin	MESH:D001971	5617	Chemical	Gene	domperidone|appos|START_ENTITY drugs|dep|domperidone investigation|nmod|drugs influencing|nsubj|investigation influencing|dobj|levels levels|compound|END_ENTITY	-LSB- Clinico-pharmacological investigation of drugs -LRB- domperidone , bromocriptine -RRB- influencing human prolactin levels from pregnancy to menopause -RSB- .
8485553	0	bromocriptine	99,112	prolactin	27,36	bromocriptine	prolactin	MESH:D001971	24683(Tax:10116)	Chemical	Gene	modulation|nmod|START_ENTITY modulation|nmod|regulation regulation|nmod|messenger messenger|compound|END_ENTITY	In vitro regulation of rat prolactin messenger ribonucleic_acid poly -LRB- A -RRB- tail length : modulation by bromocriptine .
8884536	0	bromocriptine	38,51	prolactin	86,95	bromocriptine	prolactin	MESH:D001971	5617	Chemical	Gene	administration|nmod|START_ENTITY administration|dep|pharmacology pharmacology|nmod|END_ENTITY	Nasal spray vs oral administration of bromocriptine : pharmacology and effect on serum prolactin in puerperal women .
8906007	0	bromocriptine	12,25	prolactin	44,53	bromocriptine	prolactin	MESH:D001971	5617	Chemical	Gene	START_ENTITY|dep|effects effects|nmod|END_ENTITY	Nasal spray bromocriptine : effects on serum prolactin in puerperal women .
9032565	0	bromocriptine	30,43	prolactin	78,87	bromocriptine	prolactin	MESH:D001971	5617	Chemical	Gene	administration|nmod|START_ENTITY administration|dep|pharmacology pharmacology|nmod|level level|compound|END_ENTITY	Nasal spray administration of bromocriptine : pharmacology and effect on serum prolactin level in puerperal women .
9222412	0	bromocriptine	11,24	prolactin	34,43	bromocriptine	prolactin	MESH:D001971	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Effects of bromocriptine on serum prolactin levels , pituitary weight and immunoreactive prolactin cells in estradiol-treated ovariectomized rats : an experimental model of estrogen-dependent hyperprolactinemia .
947938	1	bromocriptine	155,168	prolactin	130,139	bromocriptine	prolactin	MESH:D001971	5617	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|suppression suppression|compound|END_ENTITY	The effect of prolactin suppression by bromocriptine .
1446655	0	bromocriptine	100,113	thyrotropin-releasing_hormone	65,94	bromocriptine	thyrotropin-releasing hormone	MESH:D001971	7200	Chemical	Gene	therapy|amod|START_ENTITY END_ENTITY|nmod|therapy	Resolution of possible paradoxical responses of gonadotropins to thyrotropin-releasing_hormone with bromocriptine therapy in a patient with follicle-stimulating hormone-secreting pituitary_adenoma .
2148756	0	bromocriptine	154,167	thyrotropin-releasing_hormone	22,51	bromocriptine	thyrotropin-releasing hormone	MESH:D001971	7200	Chemical	Gene	therapy|amod|START_ENTITY candidates|nmod|therapy response|nmod|candidates response|nmod|END_ENTITY	Prolactin response to thyrotropin-releasing_hormone in normoprolactinemic patients with ovulatory_dysfunction and its use for selection of candidates for bromocriptine therapy .
819453	0	bromocriptine	122,135	thyrotropin-releasing_hormone	39,68	bromocriptine	thyrotropin-releasing hormone	MESH:D001971	7200	Chemical	Gene	effect|nmod|START_ENTITY responses|dep|effect responses|nmod|END_ENTITY	Prolactin and thyrotropin responses to thyrotropin-releasing_hormone in patients with secondary amenorrhea : the effect of bromocriptine .
3140587	0	bromocriptine	171,184	thyrotropin_releasing_hormone	90,119	bromocriptine	thyrotropin releasing hormone	MESH:D001971	7200	Chemical	Gene	treatment|nmod|START_ENTITY treatment|amod|END_ENTITY	Borderline hyperprolactinemia in infertile women : evaluation of the prolactin response to thyrotropin_releasing_hormone and double-blind placebo-controlled treatment with bromocriptine .
11207940	0	bromocriptine	19,32	tyrosine_hydroxylase	46,66	bromocriptine	tyrosine hydroxylase	MESH:D001971	25085(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY Effects|nmod|treatment Effects|nmod|END_ENTITY	Effects of chronic bromocriptine treatment on tyrosine_hydroxylase -LRB- TH -RRB- mRNA expression , TH activity and median eminence dopamine concentrations in ageing rats .
7105631	0	bromocriptine	14,27	vasopressin	43,54	bromocriptine	vasopressin	MESH:D001971	551	Chemical	Gene	START_ENTITY|acl|circulating circulating|dobj|END_ENTITY	The effect of bromocriptine on circulating vasopressin .
27069561	0	bromocriptine_mesylate	11,33	C-reactive_protein	71,89	bromocriptine mesylate	C-reactive protein	MESH:D001971	1401	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|amod|END_ENTITY	Effects of bromocriptine_mesylate on homocysteine and high-sensitivity C-reactive_protein levels in patients with type-2_diabetes_mellitus .
8332936	0	bromodeoxyuridine	45,62	tyrosinase	15,25	bromodeoxyuridine	tyrosinase	MESH:D001973	101840761	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Suppression of tyrosinase gene expression by bromodeoxyuridine in Syrian_hamster melanoma cells is not due to its incorporation into upstream or coding sequences of the tyrosinase gene .
8332936	0	bromodeoxyuridine	45,62	tyrosinase	169,179	bromodeoxyuridine	tyrosinase	MESH:D001973	101840761	Chemical	Gene	expression|nmod|START_ENTITY Suppression|nmod|expression due|nsubj|Suppression due|nmod|sequences sequences|nmod|gene gene|amod|END_ENTITY	Suppression of tyrosinase gene expression by bromodeoxyuridine in Syrian_hamster melanoma cells is not due to its incorporation into upstream or coding sequences of the tyrosinase gene .
2150777	0	bromophenacyl_bromide	10,31	phospholipase_A2	35,51	bromophenacyl bromide	phospholipase A2	MESH:C006821	151056	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effect of bromophenacyl_bromide , a phospholipase_A2 inhibitor , on the induction and maintenance of LTP in hippocampal slices .
2083242	0	bromophenol_blue	11,27	albumin	44,51	bromophenol blue	albumin	MESH:D001978	213	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of bromophenol_blue to bovine serum albumin and its succinylated forms .
26586619	0	bromophenols	20,32	glucose_6-phosphate_dehydrogenase	67,100	bromophenols	glucose 6-phosphate dehydrogenase	null	855480(Tax:4932)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of algal bromophenols and their related phenols against glucose_6-phosphate_dehydrogenase .
3179568	0	bromopride	66,76	Prolactin	0,9	bromopride	Prolactin	MESH:C013855	24683(Tax:10116)	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|levels levels|compound|END_ENTITY	Prolactin levels in male and female rats perinatally treated with bromopride .
2633842	0	bromopride	16,26	prolactin	44,53	bromopride	prolactin	MESH:C013855	24683(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY Effect|nmod|treatment Effect|nmod|levels levels|compound|END_ENTITY	Effect of acute bromopride treatment on rat prolactin levels and sexual_behavior .
26825851	9	bromopyruvate	997,1010	hMCT1	986,991	bromopyruvate	hMCT1	MESH:C017092	6566	Chemical	Gene	carrier|amod|START_ENTITY END_ENTITY|nmod|carrier	hMCT1 as a bromopyruvate carrier was functionally expressed in the cells .
10553724	0	bromperidol	17,28	CYP3A	8,13	bromperidol	CYP3A	MESH:C006820	170509(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY Role|nmod|metabolism Role|nmod|END_ENTITY	Role of CYP3A in bromperidol metabolism in rat in vitro and in vivo .
10752674	0	bromperidol	43,54	CYP3A4	15,21	bromperidol	CYP3A4	MESH:C006820	1576	Chemical	Gene	metabolism|nmod|START_ENTITY Involvement|nmod|metabolism Involvement|nmod|END_ENTITY	Involvement of CYP3A4 in the metabolism of bromperidol in vitro .
11334264	0	bropirimine	28,39	dihydropyrimidine_dehydrogenase	68,99	bropirimine	dihydropyrimidine dehydrogenase	MESH:C033560	1806	Chemical	Gene	Lack|nmod|START_ENTITY Lack|nmod|END_ENTITY	Lack of interaction between bropirimine and 5-fluorouracil on human dihydropyrimidine_dehydrogenase .
11186094	0	brotizolam	25,35	P300	39,43	brotizolam	P300	MESH:C020960	2033	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of small dose of brotizolam on P300 .
11139454	0	brotizolam	21,31	per1	63,67	brotizolam	per1	MESH:C020960	5187	Chemical	Gene	action|nmod|START_ENTITY action|nmod|END_ENTITY	Inhibitory action of brotizolam on circadian and light-induced per1 and per2 expression in the hamster suprachiasmatic nucleus .
1977709	0	broxaterol	68,78	beta-2	52,58	broxaterol	beta-2	MESH:C045916	10242	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Acute ventilatory and gas-exchange effects of a new beta-2 agonist , broxaterol , in asthmatics .
16443926	0	brucine	24,31	Bcl-2	110,115	brucine	Bcl-2	MESH:C083806	596	Chemical	Gene	effect|nmod|START_ENTITY mediated|nsubjpass|effect mediated|nmod|END_ENTITY	The apoptotic effect of brucine from the seed of Strychnos nux-vomica on human hepatoma cells is mediated via Bcl-2 and Ca2 + involved mitochondrial pathway .
22855035	0	brucine	11,18	vascular_endothelial_growth_factor	22,56	brucine	vascular endothelial growth factor	MESH:C083806	22339(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effects of brucine on vascular_endothelial_growth_factor expression and microvessel density in a nude mouse model of bone_metastasis due to breast_cancer .
8461005	0	bryostatin_1	92,104	Protein_kinase_C-alpha	0,22	bryostatin 1	Protein kinase C-alpha	MESH:C046785	5578	Chemical	Gene	down-regulated|nmod|START_ENTITY down-regulated|nsubj|END_ENTITY	Protein_kinase_C-alpha but not protein_kinase_C-epsilon is differentially down-regulated by bryostatin_1 and tetradecanoyl_phorbol_13-acetate in SH-SY5Y human neuroblastoma cells .
1374343	0	bryostatin_1	10,22	rGM-CSF	129,136	bryostatin 1	rGM-CSF	MESH:C046785	116630(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|END_ENTITY	Effect of bryostatin_1 on the in vitro radioprotective capacity of recombinant granulocyte-macrophage colony-stimulating factor -LRB- rGM-CSF -RRB- toward committed human myeloid progenitor cells -LRB- CFU-GM -RRB- .
16546974	0	bryostatin_1_and_12-O-tetradecanoylphorbol-13-acetate	24,77	RasGRP1	114,121	bryostatin 1 and 12-O-tetradecanoylphorbol-13-acetate	RasGRP1	null	19419(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Differential effects of bryostatin_1_and_12-O-tetradecanoylphorbol-13-acetate on the regulation and activation of RasGRP1 in mouse epidermal keratinocytes .
12411422	0	bucillamine	69,80	vascular_endothelial_growth_factor	24,58	bucillamine	vascular endothelial growth factor	MESH:C026535	281572(Tax:9913)	Chemical	Gene	mechanism|nmod|START_ENTITY mechanism|nmod|END_ENTITY	Inhibitory mechanism of vascular_endothelial_growth_factor -LRB- VEGF -RRB- by bucillamine .
16520738	0	buddlejasaponin_IV	28,46	iNOS	73,77	buddlejasaponin IV	iNOS	MESH:C418227	4843	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Anti-inflammatory effect of buddlejasaponin_IV through the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via the NF-kappaB inactivation .
19138736	0	budesonide	79,89	CYP3A4	32,38	budesonide	CYP3A4	MESH:D019819	1576	Chemical	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	PXR-mediated induction of human CYP3A4 and mouse Cyp3a11 by the glucocorticoid budesonide .
22898286	0	budesonide	12,22	HIF-1a	26,32	budesonide	HIF-1a	MESH:D019819	15251(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effects of budesonide on HIF-1a and VEGF expression and airway remodeling in an asthmatic_mouse model -RSB- .
26012304	0	budesonide	11,21	IL-12	43,48	budesonide	IL-12	MESH:D019819	64546(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of budesonide on the expression of IL-12 in animal model of minimal persistent inflammation of allergic_rhinitis in rats -RSB- .
16584389	0	budesonide	51,61	Multidrug_resistance_1	0,22	budesonide	Multidrug resistance 1	MESH:D019819	5243	Chemical	Gene	genotype|nmod|START_ENTITY genotype|amod|END_ENTITY	Multidrug_resistance_1 genotype and disposition of budesonide in early primary_biliary_cirrhosis .
11587995	0	budesonide	11,21	NF-kappaB	40,49	budesonide	NF-kappaB	MESH:D019819	4790	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of budesonide and formoterol on NF-kappaB , adhesion molecules , and cytokines in asthma .
15472518	0	budesonide	18,28	P-glycoprotein	93,107	budesonide	P-glycoprotein	MESH:D019819	5243	Chemical	Gene	Identification|nmod|START_ENTITY pump|nsubj|Identification pump|xcomp|END_ENTITY	Identification of budesonide and prednisone as substrates of the intestinal drug efflux pump P-glycoprotein .
17179942	0	budesonide	11,21	P-glycoprotein	25,39	budesonide	P-glycoprotein	MESH:D019819	5243	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|amod|END_ENTITY	Effects of budesonide on P-glycoprotein expression in intestinal cell lines .
24568918	0	budesonide	28,38	STAT6	56,61	budesonide	STAT6	MESH:D019819	20852(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	-LSB- Down-regulatory effects of budesonide on expression of STAT6 and ORMDL3 in lung tissues of asthmatic mice -RSB- .
16255498	0	budesonide	64,74	galectin-7	28,38	budesonide	galectin-7	MESH:D019819	3963	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of expression of galectin-7 in human nasal_polyps by budesonide .
18554472	0	budesonide	11,21	heme_oxygenase-1	29,45	budesonide	heme oxygenase-1	MESH:D019819	24451(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	-LSB- Effect of budesonide on the heme_oxygenase-1 expression in lung tissues of rats with asthma -RSB- .
12325039	0	budesonide	10,20	insulin-like_growth_factor_2	67,95	budesonide	insulin-like growth factor 2	MESH:D019819	16002(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|genes genes|amod|END_ENTITY	Effect of budesonide on the methylation and mRNA expression of the insulin-like_growth_factor_2 and c-myc genes in mouse lung_tumors .
12119225	0	budesonide	26,36	interleukin-5	71,84	budesonide	interleukin-5	MESH:D019819	16191(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	The effects of intranasal budesonide on allergen-induced production of interleukin-5 and eotaxin , airways , blood , and bone_marrow_eosinophilia , and eosinophil progenitor expansion in sensitized mice .
10464891	0	budesonide	58,68	leptin	6,12	budesonide	leptin	MESH:D019819	3952	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|END_ENTITY	Serum leptin in children with asthma treated with inhaled budesonide .
17352239	0	bufalin	45,52	Tiam1	15,20	bufalin	Tiam1	MESH:C022777	7074	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of Tiam1 in apoptosis induced by bufalin in HeLa cells .
9458368	0	bufalin	56,63	cJun	67,71	bufalin	cJun	MESH:C022777	3725	Chemical	Gene	START_ENTITY|nmod|cells cells|amod|END_ENTITY	Alterations in differentiation and apoptosis induced by bufalin in cJun overexpressing U-937 cells .
15331158	0	buflomedil	21,31	alpha1A_adrenoceptor	44,64	buflomedil	alpha1A adrenoceptor	MESH:C010651	29412(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Inhibitory effect of buflomedil on prostate alpha1A_adrenoceptor in the Wistar rat .
23087509	0	buflomedil	17,27	vascular_endothelial_growth_factor	55,89	buflomedil	vascular endothelial growth factor	MESH:C010651	83785(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|expression expression|nmod|END_ENTITY	Vasoactive agent buflomedil up-regulated expression of vascular_endothelial_growth_factor in a rat model of sciatic nerve crush_injury .
9293391	0	buflomedil_chlorhydrate	83,106	IL-8	27,31	buflomedil chlorhydrate	IL-8	null	3576	Chemical	Gene	expression|nmod|START_ENTITY expression|nsubj|modulation modulation|nmod|END_ENTITY	Differential modulation of IL-8 and TNF-alpha expression in human keratinocytes by buflomedil_chlorhydrate and pentoxifylline .
9270381	0	bulbocapnine	38,50	tyrosine_hydroxylase	14,34	bulbocapnine	tyrosine hydroxylase	MESH:C083807	280707(Tax:9913)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of tyrosine_hydroxylase by bulbocapnine .
1400320	0	bulgecin	45,53	hydrolase	9,18	bulgecin	hydrolase	MESH:C036713	7701420(Tax:562)	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	A murein hydrolase is the specific target of bulgecin in Escherichia_coli .
19406757	0	bumetanide	59,69	NKCC1	123,128	bumetanide	NKCC1	MESH:D002034	6558	Chemical	Gene	treated|nmod|START_ENTITY neonate|acl|treated activity|nmod|neonate activity|dep|K K|dep|END_ENTITY	Decreased seizure activity in a human neonate treated with bumetanide , an inhibitor of the Na -LRB- + -RRB- - K -LRB- + -RRB- -2 Cl -LRB- - -RRB- cotransporter NKCC1 .
25463517	0	bumetanide	19,29	NKCC1	72,77	bumetanide	NKCC1	MESH:D002034	83629(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY incompatible|nmod|effects incompatible|nmod|inhibition inhibition|nummod|END_ENTITY	In vivo effects of bumetanide at brain concentrations incompatible with NKCC1 inhibition on newborn DGC structure and spontaneous EEG seizures following hypoxia-induced neonatal_seizures .
10206323	0	bunitrolol	34,44	P-glycoprotein	16,30	bunitrolol	P-glycoprotein	MESH:C084811	67078(Tax:10090)	Chemical	Gene	Contribution|acl|START_ENTITY Contribution|nmod|END_ENTITY	Contribution of P-glycoprotein to bunitrolol efflux across blood-brain barrier .
1355709	0	bunitrolol	75,85	cytochrome_P-450	39,55	bunitrolol	cytochrome P-450	MESH:C084811	25251(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Purification Purification|nmod|catalyzing catalyzing|amod|END_ENTITY	Purification and characterization of a cytochrome_P-450 isozyme catalyzing bunitrolol 4-hydroxylation in liver microsomes of male rats .
1409527	0	buparvaquone	10,22	interleukin_2	44,57	buparvaquone	interleukin 2	MESH:C046326	3558	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|receptors receptors|amod|END_ENTITY	Effect of buparvaquone on the expression of interleukin_2 receptors in Theileria_annulata-infected cells .
3929649	0	bupivacaine	61,72	CO2	24,27	bupivacaine	CO2	MESH:D002045	717	Chemical	Gene	blockade|nmod|START_ENTITY END_ENTITY|nmod|blockade	Ventilatory response to CO2 following axillary blockade with bupivacaine .
23790	0	bupranolol	46,56	renin	71,76	bupranolol	renin	MESH:D002046	24715(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	-LSB- Effect of the beta-adrenergic blocking agent bupranolol on the plasma renin activity in normotensive rats -RSB- .
1445968	0	buprenorphine	48,61	Beta_endorphin	0,14	buprenorphine	Beta endorphin	MESH:D002047	5443	Chemical	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	Beta_endorphin levels during heroin , methadone , buprenorphine , and naloxone challenges : preliminary findings .
10755464	0	buprenorphine	10,23	CYP3A	27,32	buprenorphine	CYP3A	MESH:D002047	170509(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|compound|END_ENTITY	Effect of buprenorphine on CYP3A activity in rat and human liver microsomes .
17365275	0	buprenorphine	59,72	P-glycoprotein	0,14	buprenorphine	P-glycoprotein	MESH:D002047	287115(Tax:10116)	Chemical	Gene	transport|nmod|START_ENTITY mediates|dobj|transport mediates|nsubj|END_ENTITY	P-glycoprotein mediates brain-to-blood efflux transport of buprenorphine across the blood-brain barrier .
20829393	0	buprenorphine	87,100	pregnane_X_receptor	27,46	buprenorphine	pregnane X receptor	MESH:D002047	8856	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Differential activation of pregnane_X_receptor and constitutive_androstane_receptor by buprenorphine in primary human hepatocytes and HepG2 cells .
2723127	0	buprenorphine	20,33	prolactin	56,65	buprenorphine	prolactin	MESH:D002047	5617	Chemical	Gene	stimulation|amod|START_ENTITY stimulation|nmod|END_ENTITY	Naloxone suppresses buprenorphine stimulation of plasma prolactin .
2723127	5	buprenorphine	1013,1026	prolactin	899,908	buprenorphine	prolactin	MESH:D002047	5617	Chemical	Gene	mg|amod|START_ENTITY administration|nmod|mg lower|nmod|administration lower|nsubj|levels levels|compound|END_ENTITY	When 0.6 mg of naloxone was simultaneously injected with 0.3 mg buprenorphine , peak plasma prolactin levels were significantly lower -LRB- p less than 0.05 -RRB- than prolactin values after administration of 0.3 mg buprenorphine and saline .
2723127	5	buprenorphine	872,885	prolactin	899,908	buprenorphine	prolactin	MESH:D002047	5617	Chemical	Gene	injected|nmod|START_ENTITY lower|advcl|injected lower|nsubj|levels levels|compound|END_ENTITY	When 0.6 mg of naloxone was simultaneously injected with 0.3 mg buprenorphine , peak plasma prolactin levels were significantly lower -LRB- p less than 0.05 -RRB- than prolactin values after administration of 0.3 mg buprenorphine and saline .
2832191	0	buprenorphine	43,56	prolactin	99,108	buprenorphine	prolactin	MESH:D002047	5617	Chemical	Gene	interaction|nmod|START_ENTITY Evidence|nmod|interaction subtypes|nsubj|Evidence subtypes|dobj|secretion secretion|compound|END_ENTITY	Evidence for a differential interaction of buprenorphine with opiate receptor subtypes controlling prolactin secretion .
15876900	0	bupropion	33,42	CYP2D6	14,20	bupropion	CYP2D6	MESH:D016642	1565	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activity activity|compound|END_ENTITY	Inhibition of CYP2D6 activity by bupropion .
17697034	0	bupropion	3,12	CYP2E	51,56	bupropion	CYP2E	MESH:D016642	1571	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Is bupropion a more specific substrate for porcine CYP2E than chlorzoxazone and p-nitrophenol ?
11165307	0	bupropion	60,69	P-selectin	9,19	bupropion	P-selectin	MESH:D016642	6403	Chemical	Gene	response|nmod|START_ENTITY END_ENTITY|dep|response	Elevated P-selectin on platelets in depression : response to bupropion .
6406460	0	bupropion	11,20	prolactin	31,40	bupropion	prolactin	MESH:D016642	5617	Chemical	Gene	Failure|nmod|START_ENTITY Failure|acl|affect affect|dobj|END_ENTITY	Failure of bupropion to affect prolactin or growth_hormone in man .
2108517	0	buserelin	43,52	Gn-RH	27,32	buserelin	Gn-RH	MESH:D002064	2796	Chemical	Gene	analogue|appos|START_ENTITY analogue|amod|END_ENTITY	Long-term results with the Gn-RH analogue , buserelin , in metastatic_prostate_cancer .
2107012	0	buserelin	28,37	GnRH	14,18	buserelin	GnRH	MESH:D002064	2796	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Three-monthly GnRH agonist -LRB- buserelin -RRB- for prostatic_cancer .
8150899	0	buserelin	148,157	GnRH	75,79	buserelin	GnRH	MESH:D002064	2796	Chemical	Gene	induction|nmod|START_ENTITY induction|nmod|administration administration|appos|END_ENTITY	The induction of ovulation with pulsatile gonadotrophin-releasing_hormone -LRB- GnRH -RRB- administration in hyperandrogenic women after down-regulation with buserelin or suppression with an oral contraceptive .
23254679	0	buserelin	38,47	Gonadotropin-releasing_hormone	0,30	buserelin	Gonadotropin-releasing hormone	MESH:D002064	25194(Tax:10116)	Chemical	Gene	causes|compound|START_ENTITY causes|amod|END_ENTITY	Gonadotropin-releasing_hormone analog buserelin causes neuronal_loss in rat gastrointestinal tract .
1902079	0	buserelin	110,119	LH-RH	49,54	buserelin	LH-RH	MESH:D002064	25194(Tax:10116)	Chemical	Gene	mechanism|nmod|START_ENTITY action|dep|mechanism action|nmod|analogue analogue|appos|END_ENTITY	Direct action of gonadotropin-releasing_hormone -LRB- LH-RH -RRB- analogue on ovary : an alternative acting mechanism of buserelin .
1904021	0	buserelin	40,49	LH-RH	25,30	buserelin	LH-RH	MESH:D002064	2796	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Experience with a potent LH-RH agonist , buserelin , alone and in combination with testosterone for antispermatogenic activity , reversibility and toxicity in langur monkey .
6786826	0	buserelin	32,41	LH-RH	17,22	buserelin	LH-RH	MESH:D002064	2796	Chemical	Gene	START_ENTITY|nsubj|Influence Influence|nmod|analogue analogue|amod|END_ENTITY	Influence of the LH-RH analogue buserelin on cyclic ovarian function and on endometrium .
3926929	0	buserelin	72,81	LH-releasing_hormone	39,59	buserelin	LH-releasing hormone	MESH:D002064	25194(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY responsiveness|nmod|treatment responsiveness|nmod|END_ENTITY	Changes in pituitary responsiveness to LH-releasing_hormone after acute buserelin treatment : a time-course and dose-response study .
1905969	0	buserelin	140,149	LHRH	125,129	buserelin	LHRH	MESH:D002064	25194(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY protects|nsubj|agonist protects|nmod|osteopenia osteopenia|acl|associated associated|nmod|administration administration|nmod|luteinising_hormone_releasing_hormone luteinising_hormone_releasing_hormone|appos|END_ENTITY	17_beta-estradiol protects rats from osteopenia associated with administration of the luteinising_hormone_releasing_hormone -LRB- LHRH -RRB- agonist , buserelin .
3117452	0	buserelin	28,37	LHRH	14,18	buserelin	LHRH	MESH:D002064	2796	Chemical	Gene	use|acl|START_ENTITY use|nmod|agonist agonist|compound|END_ENTITY	The use of an LHRH agonist , buserelin , in the long-term management of premenstrual_syndromes .
3145318	0	buserelin	24,33	LHRH	10,14	buserelin	LHRH	MESH:D002064	2796	Chemical	Gene	Effect|appos|START_ENTITY Effect|nmod|agonist agonist|compound|END_ENTITY	Effect of LHRH agonist -LRB- buserelin -RRB- on pulsatile secretion of LHRH and LH .
3145318	0	buserelin	24,33	LHRH	61,65	buserelin	LHRH	MESH:D002064	2796	Chemical	Gene	Effect|appos|START_ENTITY Effect|nmod|secretion secretion|nmod|END_ENTITY	Effect of LHRH agonist -LRB- buserelin -RRB- on pulsatile secretion of LHRH and LH .
1586387	0	buserelin	63,72	gonadotropin-releasing_hormone	24,54	buserelin	gonadotropin-releasing hormone	MESH:D002064	2796	Chemical	Gene	START_ENTITY|nsubj|Pharmacokinetics Pharmacokinetics|nmod|agonist agonist|amod|END_ENTITY	Pharmacokinetics of the gonadotropin-releasing_hormone agonist buserelin after injection of a slow-release preparation in normal men .
3103114	0	buserelin	137,146	gonadotropin-releasing_hormone	98,128	buserelin	gonadotropin-releasing hormone	MESH:D002064	2796	Chemical	Gene	analog|appos|START_ENTITY analog|amod|END_ENTITY	Complete response of lung metastases caused by prostatic_cancer after chronic administration of a gonadotropin-releasing_hormone analog , buserelin -LRB- HOE_766 -RRB- .
7599657	0	buserelin	62,71	gonadotropin-releasing_hormone	10,40	buserelin	gonadotropin-releasing hormone	MESH:D002064	25194(Tax:10116)	Chemical	Gene	agonists|appos|START_ENTITY agonists|amod|END_ENTITY	Effect of gonadotropin-releasing_hormone agonists , nafarelin , buserelin , and leuprolide , on experimentally induced endometriosis in the rat .
8718543	0	buserelin	61,70	gonadotropin-releasing_hormone	12,42	buserelin	gonadotropin-releasing hormone	MESH:D002064	2796	Chemical	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of gonadotropin-releasing_hormone and its analogue -LRB- buserelin -RRB- on aromatase in cultured human granulosa cells -RSB- .
3115020	0	buserelin	56,65	gonadotropin_releasing_hormone	16,46	buserelin	gonadotropin releasing hormone	MESH:D002064	2796	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	An implant of a gonadotropin_releasing_hormone agonist -LRB- buserelin -RRB- which suppresses ovarian function in the macaque for 3-5 months .
10402480	0	buserelin	86,95	luteinizing_hormone-releasing_hormone	39,76	buserelin	luteinizing hormone-releasing hormone	MESH:D002064	25194(Tax:10116)	Chemical	Gene	mechanisms|appos|START_ENTITY mechanisms|nmod|effects effects|nmod|agonist agonist|amod|END_ENTITY	The mechanisms of antitumor effects of luteinizing_hormone-releasing_hormone agonist -LRB- buserelin -RRB- in 7 , _ 12-dimethylbenz -LRB- a -RRB- anthracene-induced rat mammary cancer .
8587046	0	buserelin	87,96	luteinizing_hormone-releasing_hormone	40,77	buserelin	luteinizing hormone-releasing hormone	MESH:D002064	25194(Tax:10116)	Chemical	Gene	Improvement|acl|START_ENTITY Improvement|nmod|bioavailability bioavailability|nmod|agonist agonist|amod|END_ENTITY	Improvement of nasal bioavailability of luteinizing_hormone-releasing_hormone agonist , buserelin , by cyclodextrin derivatives in rats .
2576455	0	buserelin_acetate	21,38	luteinizing_hormone-releasing_hormone	42,79	buserelin acetate	luteinizing hormone-releasing hormone	MESH:D002064	25194(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Sustained release of buserelin_acetate , a luteinizing_hormone-releasing_hormone agonist , from an injectable oily preparation utilizing ethylated beta-cyclodextrin .
22158750	0	buspirone	31,40	5-HT1A	4,10	buspirone	5-HT1A	MESH:D002065	24473(Tax:10116)	Chemical	Gene	anorexia|amod|START_ENTITY agonists|dobj|anorexia agonists|nsubj|END_ENTITY	The 5-HT1A agonists 8-OH-DPAT , buspirone and ipsapirone_attenuate stress-induced anorexia in rats .
8788529	0	buspirone	50,59	5-HT1A	25,31	buspirone	5-HT1A	MESH:D002065	24473(Tax:10116)	Chemical	Gene	agonists|amod|START_ENTITY agonists|nummod|END_ENTITY	The anxiolytic serotonin 5-HT1A receptor agonists buspirone , ipsapirone and gepirone are inhibitors of tyrosine hydroxylation in rat striatum .
10667616	0	buspirone	162,171	5-HT1A_receptor	74,89	buspirone	5-HT1A receptor	MESH:D002065	3350	Chemical	Gene	comparison|nmod|START_ENTITY effects|dep|comparison effects|nmod|lesopitron lesopitron|appos|agonist agonist|amod|END_ENTITY	The effects of the novel anxiolytic drug lesopitron , a full and selective 5-HT1A_receptor agonist , on pupil diameter and oral temperature in man : comparison with buspirone .
12589521	0	buspirone	15,24	5-HT1A_receptor	61,76	buspirone	5-HT1A receptor	MESH:D002065	3350	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|method method|acl|examining examining|dobj|function function|amod|END_ENTITY	EEG effects of buspirone and pindolol : a method of examining 5-HT1A_receptor function in humans .
17337123	0	buspirone	101,110	5-HT1A_receptor	77,92	buspirone	5-HT1A receptor	MESH:D002065	3350	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|treatment treatment|nmod|responses responses|nmod|agonist agonist|amod|END_ENTITY	Effects of citalopram treatment on hypothermic and hormonal responses to the 5-HT1A_receptor agonist buspirone in patients with major_depression and therapeutic response .
22050410	0	buspirone	10,19	5-HT1A_receptor	23,38	buspirone	5-HT1A receptor	MESH:D002065	3350	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Effect of buspirone , a 5-HT1A_receptor agonist , on esophageal motility in healthy volunteers .
8676348	0	buspirone	143,152	5-HT1A_receptor	86,101	buspirone	5-HT1A receptor	MESH:D002065	3350	Chemical	Gene	profile|nmod|START_ENTITY ligand|nmod|profile ligand|amod|END_ENTITY	8 - -LSB- 4 - -LSB- 2 - -LRB- 1,2,3,4-Tetrahydroisoquinolinyl -RSB- butyl-8-azaspiro -LSB- 4.5 -RSB- decane-7 ,9 - dione : a new 5-HT1A_receptor ligand with the same activity profile as buspirone .
9255714	0	buspirone	27,36	5-HT1A_receptor	54,69	buspirone	5-HT1A receptor	MESH:D002065	3350	Chemical	Gene	site|nmod|START_ENTITY analogues|nsubj|site analogues|nmod|END_ENTITY	The ligand-binding site of buspirone analogues at the 5-HT1A_receptor .
10102766	0	buspirone	22,31	Prolactin	0,9	buspirone	Prolactin	MESH:D002065	5617	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Prolactin response to buspirone was reduced in violent compared to nonviolent parolees .
24035672	0	buspirone	22,31	Prolactin	0,9	buspirone	Prolactin	MESH:D002065	5617	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Prolactin response to buspirone is not impaired in drug-na ve first episode patients with major_depressive_disorder .
10837886	0	buspirone	26,35	prolactin	4,13	buspirone	prolactin	MESH:D002065	5617	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	The prolactin response to buspirone in poststroke_depression : a preliminary report .
15939977	0	buspirone	50,59	prolactin	28,37	buspirone	prolactin	MESH:D002065	5617	Chemical	Gene	predicts|advcl|START_ENTITY predicts|dobj|response response|compound|END_ENTITY	Tardive_dyskinesia predicts prolactin response to buspirone challenge in people with schizophrenia .
3613693	0	buspirone	29,38	prolactin	6,15	buspirone	prolactin	MESH:D002065	5617	Chemical	Gene	Serum|nmod|START_ENTITY Serum|dobj|levels levels|compound|END_ENTITY	Serum prolactin levels after buspirone in man .
6128756	0	buspirone	10,19	prolactin	34,43	buspirone	prolactin	MESH:D002065	24683(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|compound|END_ENTITY	Effect of buspirone on rat plasma prolactin levels and striatal dopamine turnover .
6138009	0	buspirone	14,23	prolactin	27,36	buspirone	prolactin	MESH:D002065	5617	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|compound|END_ENTITY	The effect of buspirone on prolactin and growth_hormone secretion in man .
8011800	0	buspirone	11,20	prolactin	31,40	buspirone	prolactin	MESH:D002065	5617	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of buspirone on plasma prolactin and cortisol levels in major depressed and normal subjects .
2858796	0	buspirone	34,43	renin	68,73	buspirone	renin	MESH:D002065	24715(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|compound|END_ENTITY	The non-benzodiazepine anxiolytic buspirone inhibits stress-induced renin secretion and lowers heart rate .
25111583	0	busulfan	43,51	FMS-like_tyrosine_kinase_3	84,110	busulfan	FMS-like tyrosine kinase 3	MESH:D002066	2322	Chemical	Gene	analogs|compound|START_ENTITY analogs|nmod|END_ENTITY	Synergistic cytotoxicity of sorafenib with busulfan and nucleoside analogs in human FMS-like_tyrosine_kinase_3 internal tandem duplications-positive acute myeloid_leukemia cells .
7606014	0	busulfan	8,16	growth_hormone	164,178	busulfan	growth hormone	MESH:D002066	2688	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of busulfan and total_body_irradiation on growth of prepubertal children receiving bone marrow transplantation and results of treatment with recombinant human growth_hormone .
908278	0	butaclamol	55,65	growth_hormone	10,24	butaclamol	growth hormone	MESH:D002069	81668(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|dep|effects	Pulsatile growth_hormone and prolactin : effects of -LRB- + -RRB- _ butaclamol , a dopamine receptor blocking agent .
1158861	0	butanedione	86,97	malate_dehydrogenase	60,80	butanedione	malate dehydrogenase	MESH:C007366	4199	Chemical	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of essential arginyl residues in cytoplasmic malate_dehydrogenase with butanedione .
12951484	0	butein	22,28	angiotensin_converting_enzyme	51,80	butein	angiotensin converting enzyme	MESH:C040918	24310(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|inhibition inhibition|nmod|END_ENTITY	Hypotensive effect of butein via the inhibition of angiotensin_converting_enzyme .
21131551	0	butein	80,86	signal_transducer_and_activator_of_transcription_3	15,65	butein	signal transducer and activator of transcription 3	MESH:C040918	6774	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Suppression of signal_transducer_and_activator_of_transcription_3 activation by butein inhibits growth of human hepatocellular_carcinoma in vivo .
25388602	0	butenolides	4,15	PPARa	21,26	butenolides	PPARa	CHEBI:50523	5465	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Two butenolides with PPARa agonistic activity from a marine-derived Streptomyces .
4057038	0	buthiobate	11,21	cytochrome_P-450	39,55	buthiobate	cytochrome P-450	MESH:C016349	25251(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of buthiobate , a fungicide , on cytochrome_P-450 of rat liver microsomes .
21573353	0	buthionine_sulfoximine	101,123	tnf-alpha	11,20	buthionine sulfoximine	tnf-alpha	MESH:D019328	7124	Chemical	Gene	treatment|nmod|START_ENTITY END_ENTITY|nmod|treatment	Overcoming tnf-alpha and cddp resistance of a human ovarian-cancer cell-line -LRB- c30 -RRB- by treatment with buthionine_sulfoximine in combination with tnf-alpha and or cddp .
21573353	0	buthionine_sulfoximine	101,123	tnf-alpha	144,153	buthionine sulfoximine	tnf-alpha	MESH:D019328	7124	Chemical	Gene	treatment|nmod|START_ENTITY treatment|nmod|END_ENTITY	Overcoming tnf-alpha and cddp resistance of a human ovarian-cancer cell-line -LRB- c30 -RRB- by treatment with buthionine_sulfoximine in combination with tnf-alpha and or cddp .
9112626	0	butobendin	10,20	dopamine_beta-hydroxylase	24,49	butobendin	dopamine beta-hydroxylase	MESH:C030706	1621	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of butobendin on dopamine_beta-hydroxylase in vitro .
6432552	0	butorphanol	132,143	PRL	24,27	butorphanol	PRL	MESH:D002077	5617	Chemical	Gene	concentrations|nmod|START_ENTITY concentrations|nmod|END_ENTITY	Serum concentrations of PRL , GH , LH , FSH , TSH and cortisol after single administration to man of a new synthetic narcotic analgesic butorphanol .
5417050	0	butylated_hydroxyanisole	25,49	Bradykinin	0,10	butylated hydroxyanisole	Bradykinin	MESH:D002083	3827	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|END_ENTITY	Bradykinin inhibition by butylated_hydroxyanisole .
20194533	0	butylated_hydroxyanisole	48,72	CYP2J2	23,29	butylated hydroxyanisole	CYP2J2	MESH:D002083	1573	Chemical	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	Up-regulation of human CYP2J2 in HepG2 cells by butylated_hydroxyanisole is mediated by c-Jun and Nrf2 .
3791183	0	butylated_hydroxyanisole	90,114	Ornithine_decarboxylase	0,23	butylated hydroxyanisole	Ornithine decarboxylase	MESH:D002083	24609(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Ornithine_decarboxylase activity and DNA synthesis in rats after long term treatment with butylated_hydroxyanisole , sodium_saccharin or phenobarbital .
9693256	0	butylated_hydroxyanisole	10,34	catalase	38,46	butylated hydroxyanisole	catalase	MESH:D002083	40048(Tax:7227)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effect of butylated_hydroxyanisole on catalase activity and malondialdehyde content in aging Zaprionus paravittiger -LRB- diptera -RRB- .
1401495	0	butylated_hydroxyanisole	11,35	ornithine_decarboxylase	39,62	butylated hydroxyanisole	ornithine decarboxylase	MESH:D002083	18263(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effects of butylated_hydroxyanisole on ornithine_decarboxylase activity induced by ultraviolet-B and PUVA in mouse skin .
1991991	0	butylated_hydroxyanisole	11,35	ornithine_decarboxylase	39,62	butylated hydroxyanisole	ornithine decarboxylase	MESH:D002083	18263(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effects of butylated_hydroxyanisole on ornithine_decarboxylase activity and its gene expression induced by phorbol_ester tumor promoter .
8045992	0	butylated_hydroxytoluene	56,80	aldose_reductase	16,32	butylated hydroxytoluene	aldose reductase	MESH:D002084	616199(Tax:9913)	Chemical	Gene	START_ENTITY|nsubj|efficacy efficacy|nmod|inhibitor inhibitor|amod|END_ENTITY	The efficacy of aldose_reductase inhibitor , antioxidant butylated_hydroxytoluene and cysteine protease inhibitor E64 on hyperglycemia-induced metabolic changes in the organ-cultured bovine lens .
4036956	0	butylnitrite	22,34	methemoglobin	57,70	butylnitrite	methemoglobin	MESH:C024225	3048	Chemical	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	The laboratory use of butylnitrite for the production of methemoglobin .
3763398	0	butylphenyl-deoxyguanosine_triphosphate	140,179	DNA_polymerase_alpha	102,122	butylphenyl-deoxyguanosine triphosphate	DNA polymerase alpha	null	5422	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|END_ENTITY	DNA replication and UV-induced DNA repair synthesis in human fibroblasts are much less sensitive than DNA_polymerase_alpha to inhibition by butylphenyl-deoxyguanosine_triphosphate .
20197608	0	butylphthalide	11,25	GFAP	47,51	butylphthalide	GFAP	MESH:C027125	24387(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of butylphthalide on the expression of GFAP and VEGF in the hippocampus of rats with Alzheimer 's _ disease -RSB- .
10496148	0	butyrate	50,58	AA-NAT	14,20	butyrate	AA-NAT	MESH:D002087	15	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of AA-NAT and HIOMT gene expression by butyrate and cyclic_AMP in Y79 human retinoblastoma cells .
15961787	0	butyrate	36,44	Acid_sphingomyelinase	0,21	butyrate	Acid sphingomyelinase	MESH:D002087	6609	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Acid_sphingomyelinase is induced by butyrate but does not initiate the anticancer effect of butyrate in HT29 and HepG2 cells .
11889074	0	butyrate	52,60	Cdx2	30,34	butyrate	Cdx2	MESH:D002087	1045	Chemical	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Stimulation of the intestinal Cdx2 homeobox gene by butyrate in colon_cancer cells .
19276343	0	butyrate	79,87	GPR109A	0,7	butyrate	GPR109A	MESH:D002087	80885(Tax:10090)	Chemical	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	GPR109A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon .
25490566	0	butyrate	14,22	GPR41	34,39	butyrate	GPR41	MESH:D002087	2865	Chemical	Gene	START_ENTITY|dep|receptors receptors|nummod|END_ENTITY	Uptake of the butyrate receptors , GPR41 and GPR43 , in lipidic bicontinuous cubic phases suitable for in meso crystallization .
22446977	0	butyrate	12,20	HDAC	31,35	butyrate	HDAC	MESH:D002087	9734	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|compound|END_ENTITY	Hypothesis : butyrate is not an HDAC inhibitor , but a product inhibitor of deacetylation .
10734024	0	butyrate	35,43	NF-kappaB	54,63	butyrate	NF-kappaB	MESH:D002087	4790	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activity activity|amod|END_ENTITY	The luminal short-chain fatty_acid butyrate modulates NF-kappaB activity in a human colonic epithelial cell line .
17786924	0	butyrate	63,71	NF-kappaB	125,134	butyrate	NF-kappaB	MESH:D002087	4790	Chemical	Gene	promoter|nmod|START_ENTITY promoter|nmod|cells cells|dep|involvement involvement|nmod|pathway pathway|amod|END_ENTITY	Regulation of monocarboxylate transporter 1 -LRB- MCT1 -RRB- promoter by butyrate in human intestinal epithelial cells : involvement of NF-kappaB pathway .
10833422	0	butyrate	57,65	PPAR-gamma	0,10	butyrate	PPAR-gamma	MESH:D002087	5468	Chemical	Gene	upregulated|nmod|START_ENTITY upregulated|nsubjpass|END_ENTITY	PPAR-gamma is selectively upregulated in Caco-2 cells by butyrate .
15905703	0	butyrate	36,44	Tumor_necrosis_factor_alpha	0,27	butyrate	Tumor necrosis factor alpha	MESH:D002087	7124	Chemical	Gene	oxidation|amod|START_ENTITY reduces|dobj|oxidation reduces|nsubj|END_ENTITY	Tumor_necrosis_factor_alpha reduces butyrate oxidation in vitro in human colonic_mucosa : a link from inflammatory process to mucosal_damage ?
11059779	0	butyrate	84,92	androgen_receptor	37,54	butyrate	androgen receptor	MESH:D002087	367	Chemical	Gene	START_ENTITY|nsubj|activation activation|nmod|END_ENTITY	Ligand-independent activation of the androgen_receptor by the differentiation agent butyrate in human prostate_cancer cells .
18541673	0	butyrate	41,49	annexin_A1	16,26	butyrate	annexin A1	MESH:D002087	301	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Upregulation of annexin_A1 expression by butyrate in human colon_adenocarcinoma cells : role of p53 , NF-Y , and p38 mitogen-activated protein kinase .
16160080	0	butyrate	34,42	cyclin_B1	57,66	butyrate	cyclin B1	MESH:D002087	891	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	The histone deacetylase inhibitor butyrate downregulates cyclin_B1 gene expression via a p21/WAF -1 - dependent mechanism in human colon_cancer cells .
8043864	0	butyrate	11,19	erythropoietin	27,41	butyrate	erythropoietin	MESH:D002087	13856(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|receptor receptor|compound|END_ENTITY	Effects of butyrate on the erythropoietin receptor of cell line IW201 .
9931450	0	butyrate	30,38	galectin-1	48,58	butyrate	galectin-1	MESH:D002087	16852(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|gene gene|amod|END_ENTITY	Transcriptional regulation by butyrate of mouse galectin-1 gene in embryonal_carcinoma cells .
7504459	0	butyrate	47,55	germ-cell_alkaline_phosphatase	13,43	butyrate	germ-cell alkaline phosphatase	MESH:D002087	251	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of germ-cell_alkaline_phosphatase by butyrate and cyclic_AMP in BeWo_choriocarcinoma cells .
15927184	0	butyrate	23,31	growth_hormone	35,49	butyrate	growth hormone	MESH:D002087	81668(Tax:10116)	Chemical	Gene	actions|nmod|START_ENTITY actions|nmod|secretion secretion|amod|END_ENTITY	Suppressing actions of butyrate on growth_hormone -LRB- GH -RRB- secretion induced by GH-releasing hormone in rat anterior pituitary cells .
12840228	0	butyrate	46,54	histone_deacetylase	14,33	butyrate	histone deacetylase	MESH:D002087	9734	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activity activity|amod|END_ENTITY	Inhibition of histone_deacetylase activity by butyrate .
10412232	0	butyrate	39,47	phospholipase_A2	10,26	butyrate	phospholipase A2	MESH:D002087	151056	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Decreased phospholipase_A2 activity in butyrate differentiated HT29 cells .
21344672	0	butyric_acid	29,41	prestin	63,70	butyric acid	prestin	MESH:D020148	83819(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effects of retinoic_acid and butyric_acid on the expression of prestin and Gata-3 in organotypic cultures of the organ of corti of newborn rats .
9042196	0	butyrolactone_I	21,36	cdc2	50,54	butyrolactone I	cdc2	MESH:C082868	983	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Antitumor effects of butyrolactone_I , a selective cdc2 kinase inhibitor , on human lung_cancer cell lines .
17855766	0	butyryl-L-carnitine	13,32	OCTN2	85,90	butyryl-L-carnitine	OCTN2	CHEBI:21949	6584	Chemical	Gene	Transport|nmod|START_ENTITY Transport|nmod|END_ENTITY	Transport of butyryl-L-carnitine , a potential prodrug , via the carnitine transporter OCTN2 and the amino_acid transporter ATB -LRB- 0 , + -RRB- .
10421450	0	butyrylthiocholine	43,61	butyrylcholinesterase	77,98	butyrylthiocholine	butyrylcholinesterase	MESH:D002092	590	Chemical	Gene	variants|amod|START_ENTITY variants|compound|END_ENTITY	Catalytic parameters for the hydrolysis of butyrylthiocholine by human serum butyrylcholinesterase variants .
10556303	0	c	87,88	SURF1	38,43	c	SURF1	null	6834	Chemical	Gene	START_ENTITY|nsubj|analysis analysis|nmod|END_ENTITY	Expression and functional analysis of SURF1 in Leigh_syndrome patients with cytochrome c oxidase_deficiency .
16668131	0	c	67,68	phosphoenolpyruvate_carboxylase	32,63	c	phosphoenolpyruvate carboxylase	null	100101511(Tax:4577)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Posttranslational regulation of phosphoenolpyruvate_carboxylase in c -LRB- 4 -RRB- and crassulacean_Acid metabolism plants .
19013136	0	cAMP	8,12	AHR	26,29	cAMP	AHR	CHEBI:17489	196	Chemical	Gene	Role|nmod|START_ENTITY END_ENTITY|nsubj|Role	Role of cAMP in mediating AHR signaling .
16251349	0	cAMP	28,32	AKAP121	14,21	cAMP	AKAP121	CHEBI:17489	8165	Chemical	Gene	links|dobj|START_ENTITY links|nsubj|END_ENTITY	Mitochondrial AKAP121 links cAMP and src signaling to oxidative metabolism .
11959692	0	cAMP	48,52	ANP	67,70	cAMP	ANP	CHEBI:17489	100009087(Tax:9986)	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|release release|compound|END_ENTITY	Protein kinase-dependent and Ca -LRB- 2 + -RRB- - independent cAMP inhibition of ANP release in beating rabbit atria .
25296755	0	cAMP	51,55	AP1	89,92	cAMP	AP1	CHEBI:17489	3726	Chemical	Gene	Protein|compound|START_ENTITY Protein|appos|END_ENTITY	cAMP_Responsive_Element_Binding_Protein -LRB- CREB -RRB- and cAMP Co-regulate Activator Protein 1 -LRB- AP1 -RRB- - Dependent Regeneration-Associated Gene Expression and Neurite Growth .
9560322	0	cAMP	149,153	AP1	136,139	cAMP	AP1	CHEBI:17489	16476(Tax:10090)	Chemical	Gene	site|nmod|START_ENTITY site|nsubj|activator_protein_1 activator_protein_1|appos|END_ENTITY	Synergistic transcriptional activation of the mouse urokinase_plasminogen_activator -LRB- uPA -RRB- gene and of its enhancer activator_protein_1 -LRB- AP1 -RRB- site by cAMP and retinoic_acid .
9727025	0	cAMP	25,29	AP1	0,3	cAMP	AP1	CHEBI:17489	24516(Tax:10116)	Chemical	Gene	response|compound|START_ENTITY mediate|dobj|response mediate|nsubj|proteins proteins|compound|END_ENTITY	AP1 proteins mediate the cAMP response of the dopamine beta-hydroxylase gene .
16844078	0	cAMP	0,4	AQP2	35,39	cAMP	AQP2	CHEBI:17489	359	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	cAMP regulates vasopressin-induced AQP2 expression via protein kinase A-independent pathway .
6301159	0	cAMP	30,34	ATPase	46,52	cAMP	ATPase	CHEBI:17489	1769	Chemical	Gene	cyclic_nucleotides|dep|START_ENTITY cyclic_nucleotides|appos|activity activity|compound|END_ENTITY	-LSB- Level of cyclic_nucleotides -LRB- cAMP and cGMP -RRB- , ATPase activity and calcium ion transport in hamster lymphocytes during tumor growth -RSB- .
9439616	0	cAMP	56,60	ATPase	37,43	cAMP	ATPase	CHEBI:17489	1769	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Regulation of endothelial Na -LRB- + -RRB- - K -LRB- + -RRB- - ATPase activity by cAMP .
9016773	0	cAMP	26,30	Adrenomedullin	0,14	cAMP	Adrenomedullin	CHEBI:17489	133	Chemical	Gene	accumulation|compound|START_ENTITY stimulates|dobj|accumulation stimulates|nsubj|END_ENTITY	Adrenomedullin stimulates cAMP accumulation and inhibits atrial natriuretic peptide gene expression in cardiomyocytes .
11751586	0	cAMP	46,50	Akt	34,37	cAMP	Akt	CHEBI:17489	24185(Tax:10116)	Chemical	Gene	protein|amod|START_ENTITY Regulation|nmod|protein Regulation|nmod|END_ENTITY	Regulation of the PRL promoter by Akt through cAMP response element binding protein .
12089143	0	cAMP	0,4	Akt	19,22	cAMP	Akt	CHEBI:17489	207	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	cAMP inhibition of Akt is mediated by activated and phosphorylated Rap1b .
16945353	0	cAMP	15,19	Akt	118,121	cAMP	Akt	CHEBI:17489	24185(Tax:10116)	Chemical	Gene	analog|compound|START_ENTITY suppresses|nsubj|analog suppresses|nmod|activation activation|nmod|pathway pathway|compound|END_ENTITY	Cell-permeable cAMP analog suppresses 6-hydroxydopamine-induced apoptosis in PC12 cells through the activation of the Akt pathway .
19194991	0	cAMP	106,110	Akt	89,92	cAMP	Akt	CHEBI:17489	11651(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|5 5|dep|expression expression|amod|Ca Ca|nmod|END_ENTITY	5 ' - N-ethylcarboxamide induces IL-6 expression via MAPKs and NF-kappaB activation through Akt , Ca -LRB- 2 + -RRB- / PKC , cAMP signaling pathways in mouse embryonic stem cells .
22065948	0	cAMP	7,11	Akt	31,34	cAMP	Akt	CHEBI:17489	207	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Beyond cAMP : The Regulation of Akt and GSK3 by Dopamine Receptors .
15129016	0	cAMP	26,30	Angiotensin_II	0,14	cAMP	Angiotensin II	CHEBI:17489	11847(Tax:10090)	Chemical	Gene	production|compound|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates cAMP production and protein tyrosine phosphorylation in mouse spermatozoa .
21845073	0	cAMP	109,113	Angiotensin_II	39,53	cAMP	Angiotensin II	CHEBI:17489	183	Chemical	Gene	Cbfa1/RANKL|nmod|START_ENTITY regulating|dobj|Cbfa1/RANKL Blockade|acl|regulating Blockade|compound|END_ENTITY	Reciprocal roles of angiotensin_II and Angiotensin_II Receptors Blockade -LRB- ARB -RRB- in regulating Cbfa1/RANKL via cAMP signaling pathway : possible mechanism for hypertension-related osteoporosis and antagonistic effect of ARB on hypertension-related osteoporosis .
23830406	0	cAMP	39,43	Angiotensin_II	0,14	cAMP	Angiotensin II	CHEBI:17489	24179(Tax:10116)	Chemical	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Angiotensin_II inhibits ADH-stimulated cAMP : role on O2 - and transport-related oxygen consumption in the loop of Henle .
6298010	0	cAMP	32,36	Angiotensin_II	0,14	cAMP	Angiotensin II	CHEBI:17489	183	Chemical	Gene	accumulation|compound|START_ENTITY inhibits|dobj|accumulation inhibits|nsubj|END_ENTITY	Angiotensin_II inhibits hepatic cAMP accumulation induced by glucagon and epinephrine and their metabolic effects .
8023891	0	cAMP	58,62	Angiotensin_II	0,14	cAMP	Angiotensin II	CHEBI:17489	183	Chemical	Gene	independent|advmod|START_ENTITY independent|nsubj|stimulation stimulation|compound|END_ENTITY	Angiotensin_II stimulation of Na-H antiporter activity is cAMP independent in OKP cells .
8381612	0	cAMP	49,53	Angiotensin_II	0,14	cAMP	Angiotensin II	CHEBI:17489	24179(Tax:10116)	Chemical	Gene	formation|compound|START_ENTITY enhancement|nmod|formation enhancement|compound|END_ENTITY	Angiotensin_II enhancement of hormone-stimulated cAMP formation in cultured vascular smooth muscle cells .
9103517	0	cAMP	56,60	Angiotensin_II	0,14	cAMP	Angiotensin II	CHEBI:17489	24179(Tax:10116)	Chemical	Gene	agonists|compound|START_ENTITY potentiates|nmod|agonists potentiates|nsubj|END_ENTITY	Angiotensin_II potentiates vasodilation of rat aorta by cAMP elevating agonists .
9502119	0	cAMP	49,53	Angiotensin_II	0,14	cAMP	Angiotensin II	CHEBI:17489	24179(Tax:10116)	Chemical	Gene	accumulation|compound|START_ENTITY potentiates|dobj|accumulation potentiates|nsubj|END_ENTITY	Angiotensin_II potentiates vasopressin-dependent cAMP accumulation in CHO transfected cells .
14701824	0	cAMP	38,42	Apolipoprotein_A-I	0,18	cAMP	Apolipoprotein A-I	CHEBI:17489	100772590	Chemical	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Apolipoprotein_A-I activates cellular cAMP signaling through the ABCA1 transporter .
2176520	0	cAMP	49,53	Beta_2-adrenoceptor	0,19	cAMP	Beta 2-adrenoceptor	CHEBI:17489	154	Chemical	Gene	up-regulation|dep|START_ENTITY up-regulation|advmod|END_ENTITY	Beta_2-adrenoceptor up-regulation in relation to cAMP production in human lymphocytes after physical exercise .
8974046	0	cAMP	126,130	Beta_2-adrenoceptor	0,19	cAMP	Beta 2-adrenoceptor	CHEBI:17489	154	Chemical	Gene	pathway|compound|START_ENTITY causes|nmod|pathway causes|nsubj|activation activation|amod|END_ENTITY	Beta_2-adrenoceptor activation by zinterol causes protein phosphorylation , contractile effects and relaxant effects through a cAMP pathway in human atrium .
9920447	0	cAMP	63,67	Brain_natriuretic_peptide	0,25	cAMP	Brain natriuretic peptide	CHEBI:17489	25105(Tax:10116)	Chemical	Gene	enhances|dobj|START_ENTITY enhances|nsubj|END_ENTITY	Brain_natriuretic_peptide enhances the endothelium-independent cAMP and vasorelaxant responses of calcitonin_gene-related_peptide in rat aorta .
10341237	0	cAMP	68,72	CA1	130,133	cAMP	CA1	CHEBI:17489	310218(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	The mitogen-activated protein kinase cascade couples PKA and PKC to cAMP response element binding protein phosphorylation in area CA1 of hippocampus .
15489022	0	cAMP	14,18	CA1	34,37	cAMP	CA1	CHEBI:17489	12346(Tax:10090)	Chemical	Gene	levels|compound|START_ENTITY levels|nmod|END_ENTITY	Regulation of cAMP levels in area CA1 of hippocampus by Gi/o-coupled receptors is stimulus dependent in mice .
20360387	0	cAMP	107,111	CARM1	0,5	cAMP	CARM1	CHEBI:17489	10498	Chemical	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	CARM1 mediates the ligand-independent and tamoxifen-resistant activation of the estrogen_receptor_alpha by cAMP .
10857864	0	cAMP	0,4	CD14	13,17	cAMP	CD14	CHEBI:17489	12475(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nummod|END_ENTITY	cAMP induces CD14 expression in murine macrophages via increased transcription .
21628448	0	cAMP	31,35	CFTR	101,105	cAMP	CFTR	CHEBI:17489	1080	Chemical	Gene	production|compound|START_ENTITY production|dep|role role|nmod|END_ENTITY	Defective adenosine-stimulated cAMP production in cystic_fibrosis_airway_epithelia : a novel role for CFTR in cell signaling .
25762723	0	cAMP	34,38	CFTR	152,156	cAMP	CFTR	CHEBI:17489	1080	Chemical	Gene	START_ENTITY|nmod|complexes complexes|nmod|Multidrug_Resistance_Protein_4 Multidrug_Resistance_Protein_4|appos|END_ENTITY	Compartmentalized Accumulation of cAMP near complexes of Multidrug_Resistance_Protein_4 -LRB- MRP4 -RRB- and Cystic_Fibrosis_Transmembrane_Conductance_Regulator -LRB- CFTR -RRB- Contributes to Drug-induced Diarrhea .
9142920	0	cAMP	14,18	CFTR	0,4	cAMP	CFTR	CHEBI:17489	12638(Tax:10090)	Chemical	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	CFTR mediates cAMP - and Ca2 + - activated duodenal epithelial HCO3 - secretion .
10319317	0	cAMP	59,63	CREB	101,105	cAMP	CREB	CHEBI:17489	1385	Chemical	Gene	START_ENTITY|dep|protein protein|appos|END_ENTITY	Inducible binding of cyclic_adenosine_3 ' ,5 ' - monophosphate -LRB- cAMP -RRB- - responsive element binding protein -LRB- CREB -RRB- to a cAMP-responsive promoter in vivo .
10620495	0	cAMP	107,111	CREB	74,78	cAMP	CREB	CHEBI:17489	1385	Chemical	Gene	action|compound|START_ENTITY regulates|dobj|action site|acl:relcl|regulates site|compound|END_ENTITY	Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase promoter contains a CREB binding site that regulates cAMP action in Caco-2 cells .
10634409	0	cAMP	58,62	CREB	97,101	cAMP	CREB	CHEBI:17489	1385	Chemical	Gene	response|compound|START_ENTITY response|dep|protein protein|appos|END_ENTITY	Loss of expression of the ubiquitous transcription factor cAMP response element-binding protein -LRB- CREB -RRB- and compensatory overexpression of the activator CREMtau in the human adrenocortical_cancer cell line H295R .
10792992	0	cAMP	23,27	CREB	90,94	cAMP	CREB	CHEBI:17489	1385	Chemical	Gene	responsive|advmod|START_ENTITY core|amod|responsive flanking|dobj|core Sequences|acl|flanking influence|nsubj|Sequences influence|dobj|sensitivity sensitivity|amod|END_ENTITY	Sequences flanking the cAMP responsive core of the HTLV-I tax response elements influence CREB protease sensitivity .
10976922	0	cAMP	26,30	CREB	20,24	cAMP	CREB	CHEBI:17489	12912(Tax:10090)	Chemical	Gene	protein|amod|START_ENTITY isoform|appos|protein isoform|compound|END_ENTITY	A dominant negative CREB -LRB- cAMP response element-binding protein -RRB- isoform inhibits thyrocyte growth , thyroid-specific gene expression , differentiation , and function .
11108142	0	cAMP	14,18	CREB	56,60	cAMP	CREB	CHEBI:17489	81646(Tax:10116)	Chemical	Gene	ICERIIgamma|compound|START_ENTITY inhibits|nsubj|ICERIIgamma inhibits|dobj|END_ENTITY	The inducible cAMP early repressor ICERIIgamma inhibits CREB and AP-1 transcription but not AT1 receptor gene expression in vascular smooth muscle cells .
11121103	0	cAMP	51,55	CREB	0,4	cAMP	CREB	CHEBI:17489	12912(Tax:10090)	Chemical	Gene	regulation|nmod|START_ENTITY involved|nmod|regulation involved|nsubjpass|END_ENTITY	CREB is involved in mouse annexin_A1 regulation by cAMP and glucocorticoids .
11331083	0	cAMP	18,22	CREB	57,61	cAMP	CREB	CHEBI:17489	81646(Tax:10116)	Chemical	Gene	protein|compound|START_ENTITY Expression|nmod|protein Expression|appos|END_ENTITY	Expression of the cAMP response element binding protein -LRB- CREB -RRB- in hippocampus produces an antidepressant effect .
11535812	0	cAMP	20,24	CREB	132,136	cAMP	CREB	CHEBI:17489	1385	Chemical	Gene	effects|nmod|START_ENTITY signals|nsubj|effects signals|xcomp|target target|dobj|activation activation|nmod|END_ENTITY	Distinct effects of cAMP and mitogenic signals on CREB-binding_protein recruitment impart specificity to target gene activation via CREB .
11574420	0	cAMP	100,104	CREB	133,137	cAMP	CREB	CHEBI:17489	81646(Tax:10116)	Chemical	Gene	responsive|advmod|START_ENTITY phosphorylation|amod|responsive phosphorylation|appos|END_ENTITY	Hexosamine-induced fibronectin protein synthesis in mesangial cells is associated with increases in cAMP responsive element binding -LRB- CREB -RRB- phosphorylation and nuclear CREB : the involvement of protein kinases A and C. Hyperglycemia-induced alterations in mesangial -LRB- MES -RRB- cell function and extracellular matrix protein accumulation are seen in diabetic_glomerulopathy .
11969286	0	cAMP	9,13	CREB	71,75	cAMP	CREB	CHEBI:17489	12912(Tax:10090)	Chemical	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Coupling cAMP signaling to transcription in the liver : pivotal role of CREB and CREM .
12107181	0	cAMP	117,121	CREB	196,200	cAMP	CREB	CHEBI:17489	1385	Chemical	Gene	involved|nmod|START_ENTITY involved|nmod|HNF4_alpha HNF4_alpha|appos|END_ENTITY	The coactivator PGC-1 is involved in the regulation of the liver carnitine palmitoyltransferase I gene expression by cAMP in combination with HNF4_alpha and cAMP-response_element-binding_protein -LRB- CREB -RRB- .
12107181	6	cAMP	925,929	CREB	1004,1008	cAMP	CREB	CHEBI:17489	1385	Chemical	Gene	involved|nmod|START_ENTITY involved|nmod|HNF4_alpha HNF4_alpha|appos|END_ENTITY	Our data strongly suggest that the coactivator PGC-1 is involved in the regulation of this gene expression by cAMP in combination with HNF4_alpha and cAMP-response_element-binding_protein -LRB- CREB -RRB- .
12111373	0	cAMP	56,60	CREB	88,92	cAMP	CREB	CHEBI:17489	1385	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular cloning and characterization of a novel human cAMP response element-binding -LRB- CREB -RRB- gene -LRB- CREB4 -RRB- .
12409294	0	cAMP	5,9	CREB	44,48	cAMP	CREB	CHEBI:17489	81646(Tax:10116)	Chemical	Gene	response|compound|START_ENTITY response|dep|protein protein|appos|END_ENTITY	Ca2 + / cAMP response element-binding protein -LRB- CREB -RRB- - dependent activation of Per1 is required for light-induced signaling in the suprachiasmatic nucleus circadian clock .
12558964	0	cAMP	81,85	CREB	40,44	cAMP	CREB	CHEBI:17489	1385	Chemical	Gene	levels|nmod|START_ENTITY increasing|dobj|levels signalling|advcl|increasing signalling|nmod|END_ENTITY	Synaptic activity induces signalling to CREB without increasing global levels of cAMP in hippocampal neurons .
12658105	0	cAMP	65,69	CREB	97,101	cAMP	CREB	CHEBI:17489	81646(Tax:10116)	Chemical	Gene	cyclic_adenosine_monophosphate|dep|START_ENTITY protein|amod|cyclic_adenosine_monophosphate protein|appos|END_ENTITY	The decreased phosphorylation of cyclic_adenosine_monophosphate -LRB- cAMP -RRB- response element binding -LRB- CREB -RRB- protein in the central amygdala acts as a molecular substrate for anxiety related to ethanol withdrawal in rats .
12718894	0	cAMP	82,86	CREB	24,28	cAMP	CREB	CHEBI:17489	1385	Chemical	Gene	responsiveness|compound|START_ENTITY requirement|nmod|responsiveness reveals|dobj|requirement reveals|nsubj|analysis analysis|nmod|genes genes|compound|END_ENTITY	Genome-wide analysis of CREB target genes reveals a core promoter requirement for cAMP responsiveness .
12843242	0	cAMP	83,87	CREB	19,23	cAMP	CREB	CHEBI:17489	81646(Tax:10116)	Chemical	Gene	pathway|compound|START_ENTITY blockade|nmod|pathway reversed|nmod|blockade reversed|nsubjpass|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation of CREB and mechanical_hyperalgesia is reversed by blockade of the cAMP pathway in a time-dependent manner after repeated intramuscular_acid injections .
12939274	0	cAMP	37,41	CREB	68,72	cAMP	CREB	CHEBI:17489	81646(Tax:10116)	Chemical	Gene	activation|compound|START_ENTITY activation|nmod|subset subset|nmod|genes genes|compound|END_ENTITY	Deacetylase activity is required for cAMP activation of a subset of CREB target genes .
1352481	0	cAMP	38,42	CREB	97,101	cAMP	CREB	CHEBI:17489	81646(Tax:10116)	Chemical	Gene	induction|compound|START_ENTITY attenuation|nmod|induction requires|nsubj|attenuation requires|dobj|dephosphorylation dephosphorylation|nmod|END_ENTITY	Transcriptional attenuation following cAMP induction requires PP-1-mediated dephosphorylation of CREB .
14519530	0	cAMP	25,29	CREB	64,68	cAMP	CREB	CHEBI:17489	81646(Tax:10116)	Chemical	Gene	protein|amod|START_ENTITY injection|nmod|protein injection|appos|END_ENTITY	Intrathecal injection of cAMP response element binding protein -LRB- CREB -RRB- antisense oligonucleotide attenuates tactile_allodynia caused by partial sciatic nerve ligation .
14668092	0	cAMP	150,154	CREB	44,48	cAMP	CREB	CHEBI:17489	1385	Chemical	Gene	MAPK|compound|START_ENTITY involvement|nmod|MAPK evidence|nmod|involvement activation|dep|evidence activation|compound|END_ENTITY	Dexamethasone-induced and estradiol-induced CREB activation and annexin_1 expression in CCRF-CEM lymphoblastic cells : evidence for the involvement of cAMP and p38 MAPK .
15550512	0	cAMP	38,42	CREB	86,90	cAMP	CREB	CHEBI:17489	12912(Tax:10090)	Chemical	Gene	monophosphate|appos|START_ENTITY enhances|nsubj|monophosphate enhances|dobj|phosphorylation phosphorylation|appos|END_ENTITY	Cyclic_adenosine_3 ' ,5 ' - monophosphate -LRB- cAMP -RRB- enhances cAMP-responsive element binding -LRB- CREB -RRB- protein phosphorylation and phospho-CREB interaction with the mouse steroidogenic_acute_regulatory_protein gene promoter .
15691874	0	cAMP	55,59	CREB	112,116	cAMP	CREB	CHEBI:17489	1385	Chemical	Gene	pathway|compound|START_ENTITY genes|nmod|pathway Identification|nmod|genes Identification|dep|role role|nmod|element element|appos|END_ENTITY	Identification of human myometrial target genes of the cAMP pathway : the role of cAMP-response element binding -LRB- CREB -RRB- and modulator -LRB- CREMalpha and CREMtau2alpha -RRB- proteins .
16125054	0	cAMP	4,8	CREB	38,42	cAMP	CREB	CHEBI:17489	12912(Tax:10090)	Chemical	Gene	pathway|compound|START_ENTITY activates|nsubj|pathway activates|dobj|END_ENTITY	The cAMP signalling pathway activates CREB through PKA , p38 and MSK1 in NIH 3T3 cells .
17065410	0	cAMP	0,4	CREB	31,35	cAMP	CREB	CHEBI:17489	1385	Chemical	Gene	element-binding|compound|START_ENTITY element-binding|appos|END_ENTITY	cAMP response element-binding -LRB- CREB -RRB- signalling and ovarian surface epithelial cell survival .
17635106	0	cAMP	66,70	CREB	50,54	cAMP	CREB	CHEBI:17489	12912(Tax:10090)	Chemical	Gene	activation|compound|START_ENTITY cross-talk|nmod|activation cross-talk|nmod|END_ENTITY	Human nuclear pregnane_X_receptor cross-talk with CREB to repress cAMP activation of the glucose-6-phosphatase gene .
18086876	0	cAMP	147,151	CREB	187,191	cAMP	CREB	CHEBI:17489	81646(Tax:10116)	Chemical	Gene	response|appos|START_ENTITY coordinated|nmod|response coordinated|dobj|protein protein|appos|END_ENTITY	Glucose-dependent_insulinotropic_polypeptide-mediated up-regulation of beta-cell antiapoptotic Bcl-2 gene expression is coordinated by cyclic_AMP -LRB- cAMP -RRB- response element binding protein -LRB- CREB -RRB- and cAMP-responsive CREB coactivator 2 .
18957421	2	cAMP	344,348	CREB	314,318	cAMP	CREB	CHEBI:17489	1385	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|cAMP-responsive_element-binding_protein cAMP-responsive_element-binding_protein|appos|END_ENTITY	cAMP-responsive_element-binding_protein -LRB- CREB -RRB- is a primary target for cAMP signaling , and we have shown that activation of CREB promotes adipogenesis and adipocyte survival .
19155497	0	cAMP	45,49	CREB	130,134	cAMP	CREB	CHEBI:17489	1385	Chemical	Gene	motif|compound|START_ENTITY promoter|compound|motif flanking|dobj|promoter islands|acl|flanking status|nmod|islands determines|nsubj|status determines|dobj|binding binding|compound|END_ENTITY	Methylation status of CpG islands flanking a cAMP response element motif on the protein phosphatase 2Ac alpha promoter determines CREB binding and activity .
21701076	0	cAMP	0,4	CREB	39,43	cAMP	CREB	CHEBI:17489	12912(Tax:10090)	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	cAMP response element-binding protein -LRB- CREB -RRB- is required for epidermal_growth_factor -LRB- EGF -RRB- - induced cell proliferation and serum response element activation in neural stem cells isolated from the forebrain subventricular zone of adult mice .
21925258	5	cAMP	732,736	CREB	763,767	cAMP	CREB	CHEBI:17489	81646(Tax:10116)	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Western blotting was used to detect the phosphorylation of the cAMP response element-binding -LRB- CREB -RRB- protein .
22505473	0	cAMP	0,4	CREB	31,35	cAMP	CREB	CHEBI:17489	1385	Chemical	Gene	element-binding|compound|START_ENTITY element-binding|appos|END_ENTITY	cAMP response element-binding -LRB- CREB -RRB- recruitment following a specific CpG demethylation leads to the elevated expression of the matrix_metalloproteinase_13 in human articular chondrocytes and osteoarthritis .
23038261	0	cAMP	110,114	CREB	149,153	cAMP	CREB	CHEBI:17489	1385	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Rit-mediated stress resistance involves a p38-mitogen - and stress-activated protein kinase 1 -LRB- MSK1 -RRB- - dependent cAMP response element-binding protein -LRB- CREB -RRB- activation cascade .
24269928	4	cAMP	821,825	CREB	899,903	cAMP	IL-8	CHEBI:17489	3576	Chemical	Gene	levels|compound|START_ENTITY levels|nmod|cAMP_response_element_binding_protein cAMP_response_element_binding_protein|appos|END_ENTITY	We also measured cAMP levels and phosphorylation of the cAMP_response_element_binding_protein -LRB- CREB -RRB- .
24438093	0	cAMP	93,97	CREB	0,4	cAMP	CREB	CHEBI:17489	12912(Tax:10090)	Chemical	Gene	signalling|compound|START_ENTITY downstream|nmod|signalling transcription|nmod|downstream regulates|dobj|transcription regulates|nsubj|phosphorylation phosphorylation|compound|END_ENTITY	CREB phosphorylation at Ser133 regulates transcription via distinct mechanisms downstream of cAMP and MAPK signalling .
24898566	0	cAMP	30,34	CREB	36,40	cAMP	CREB	CHEBI:17489	1385	Chemical	Gene	differences|nmod|START_ENTITY differences|dep|END_ENTITY	Human cellular differences in cAMP -- CREB signaling correlate with light-dependent melatonin suppression and bipolar_disorder .
24953280	1	cAMP	353,357	CREB	393,397	cAMP	CART	CHEBI:17489	29131(Tax:10116)	Chemical	Gene	protein|dep|START_ENTITY protein|appos|END_ENTITY	Repeated exposure to addictive drugs enhances dopamine receptor -LRB- DR -RRB- signaling and the ultimate phosphorylation of the cyclic_adenosine_5 ' - monophosphate -LRB- cAMP -RRB- - response element-binding protein -LRB- CREB -RRB- - regulated cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- expression in the nucleus accumbens -LRB- NAcc -RRB- .
25150575	0	cAMP	23,27	CREB	54,58	cAMP	CREB	CHEBI:17489	1385	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Genetic variants in a ` cAMP element binding protein ' -LRB- CREB -RRB- - dependent histone acetylation pathway influence memory performance in cognitively healthy elderly individuals .
25662274	0	cAMP	34,38	CREB	121,125	cAMP	CREB	CHEBI:17489	12912(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY Stimulation|nmod|expression controlled|nsubjpass|Stimulation controlled|nmod|inhibition inhibition|nmod|SIK1 SIK1|nmod|CRTC2 CRTC2|appos|co-activator co-activator|nmod|END_ENTITY	Stimulation of StAR expression by cAMP is controlled by inhibition of highly inducible SIK1 via CRTC2 , a co-activator of CREB .
7628390	0	cAMP	189,193	CREB	131,135	cAMP	CREB	CHEBI:17489	81646(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY signaling|nsubj|regulation encoding|parataxis|signaling encoding|dobj|,5 ,5|dep|cAMP cAMP|dep|protein protein|appos|END_ENTITY	Expression of the gene encoding transcription factor cyclic_adenosine_3 ' ,5 ' - monophosphate -LRB- cAMP -RRB- response element-binding protein -LRB- CREB -RRB- : regulation by follicle-stimulating hormone-induced cAMP signaling in primary rat Sertoli cells .
7628390	0	cAMP	91,95	CREB	131,135	cAMP	CREB	CHEBI:17489	81646(Tax:10116)	Chemical	Gene	START_ENTITY|dep|protein protein|appos|END_ENTITY	Expression of the gene encoding transcription factor cyclic_adenosine_3 ' ,5 ' - monophosphate -LRB- cAMP -RRB- response element-binding protein -LRB- CREB -RRB- : regulation by follicle-stimulating hormone-induced cAMP signaling in primary rat Sertoli cells .
8332500	0	cAMP	4,8	CREB	43,47	cAMP	CREB	CHEBI:17489	1385	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	The cAMP response element binding protein , CREB , is a potent inhibitor of diverse transcriptional activators .
8336722	0	cAMP	159,163	CREB	88,92	cAMP	CREB	CHEBI:17489	1385	Chemical	Gene	Cyclic_AMP|appos|START_ENTITY regulates|nsubj|Cyclic_AMP Coupling|acl:relcl|regulates Coupling|nmod|factor factor|acl:relcl|limited limited|nsubj|END_ENTITY	Coupling of hormonal stimulation and transcription via the cyclic_AMP-responsive factor CREB is rate limited by nuclear entry of protein kinase A. Cyclic_AMP -LRB- cAMP -RRB- regulates a number of eukaryotic genes by mediating the protein kinase A -LRB- PKA -RRB- - dependent phosphorylation of the CREB transcription factor at Ser-133 .
8662977	0	cAMP	76,80	CREB	115,119	cAMP	CREB	CHEBI:17489	81646(Tax:10116)	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Neuronal activity increases the phosphorylation of the transcription factor cAMP response element-binding protein -LRB- CREB -RRB- in rat hippocampus and cortex .
8813728	0	cAMP	135,139	CREB	129,133	cAMP	CREB	CHEBI:17489	1385	Chemical	Gene	protein|amod|START_ENTITY END_ENTITY|appos|protein	An alternatively spliced polycistronic mRNA encoding cyclic_adenosine_3 ' ,5 ' - monophosphate -LRB- cAMP -RRB- - responsive transcription factor CREB -LRB- cAMP response element-binding protein -RRB- in human testis extinguishes expression of an internally translated inhibitor CREB isoform .
8813728	0	cAMP	135,139	CREB	252,256	cAMP	CREB	CHEBI:17489	1385	Chemical	Gene	protein|amod|START_ENTITY CREB|appos|protein monophosphate|dep|CREB ,5|dep|monophosphate encoding|dobj|,5 mRNA|acl|encoding extinguishes|nsubj|mRNA extinguishes|dobj|expression expression|nmod|isoform isoform|compound|END_ENTITY	An alternatively spliced polycistronic mRNA encoding cyclic_adenosine_3 ' ,5 ' - monophosphate -LRB- cAMP -RRB- - responsive transcription factor CREB -LRB- cAMP response element-binding protein -RRB- in human testis extinguishes expression of an internally translated inhibitor CREB isoform .
8813728	0	cAMP	91,95	CREB	129,133	cAMP	CREB	CHEBI:17489	1385	Chemical	Gene	monophosphate|appos|START_ENTITY monophosphate|dep|END_ENTITY	An alternatively spliced polycistronic mRNA encoding cyclic_adenosine_3 ' ,5 ' - monophosphate -LRB- cAMP -RRB- - responsive transcription factor CREB -LRB- cAMP response element-binding protein -RRB- in human testis extinguishes expression of an internally translated inhibitor CREB isoform .
8813728	0	cAMP	91,95	CREB	252,256	cAMP	CREB	CHEBI:17489	1385	Chemical	Gene	monophosphate|appos|START_ENTITY ,5|dep|monophosphate encoding|dobj|,5 mRNA|acl|encoding extinguishes|nsubj|mRNA extinguishes|dobj|expression expression|nmod|isoform isoform|compound|END_ENTITY	An alternatively spliced polycistronic mRNA encoding cyclic_adenosine_3 ' ,5 ' - monophosphate -LRB- cAMP -RRB- - responsive transcription factor CREB -LRB- cAMP response element-binding protein -RRB- in human testis extinguishes expression of an internally translated inhibitor CREB isoform .
9178746	0	cAMP	106,110	CREB	145,149	cAMP	CREB	CHEBI:17489	81646(Tax:10116)	Chemical	Gene	response|compound|START_ENTITY pathway|appos|response adenosine_monophosphate|dep|pathway phosphorylation|amod|adenosine_monophosphate phosphorylation|appos|END_ENTITY	Somatostatin acts by inhibiting the cyclic_3 ' ,5 ' - adenosine_monophosphate -LRB- cAMP -RRB- / protein_kinase_A pathway , cAMP response element-binding protein -LRB- CREB -RRB- phosphorylation , and CREB transcription potency .
9178746	0	cAMP	74,78	CREB	145,149	cAMP	CREB	CHEBI:17489	81646(Tax:10116)	Chemical	Gene	adenosine_monophosphate|dep|START_ENTITY phosphorylation|amod|adenosine_monophosphate phosphorylation|appos|END_ENTITY	Somatostatin acts by inhibiting the cyclic_3 ' ,5 ' - adenosine_monophosphate -LRB- cAMP -RRB- / protein_kinase_A pathway , cAMP response element-binding protein -LRB- CREB -RRB- phosphorylation , and CREB transcription potency .
9352075	0	cAMP	38,42	CREB	14,18	cAMP	CREB	CHEBI:17489	1385	Chemical	Gene	+|compound|START_ENTITY phosphorylation|nmod|+ phosphorylation|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of CREB phosphorylation by cAMP and Ca2 + in parotid acinar cells .
9521699	0	cAMP	23,27	CREB	61,65	cAMP	CREB	CHEBI:17489	1385	Chemical	Gene	protein|compound|START_ENTITY Phosphorylation|nmod|protein END_ENTITY|nsubj|Phosphorylation	Phosphorylation of the cAMP response element binding protein CREB by cAMP-dependent protein kinase A and glycogen synthase kinase-3 alters DNA-binding affinity , conformation , and increases net charge .
9597751	0	cAMP	28,32	CREB	53,57	cAMP	CREB	CHEBI:17489	12912(Tax:10090)	Chemical	Gene	signalling|compound|START_ENTITY expression|nmod|signalling expression|dep|role role|nmod|END_ENTITY	Coupling gene expression to cAMP signalling : role of CREB and CREM .
12111373	0	cAMP	56,60	CREB4	101,106	cAMP	CREB4	CHEBI:17489	148327	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular cloning and characterization of a novel human cAMP response element-binding -LRB- CREB -RRB- gene -LRB- CREB4 -RRB- .
10601034	0	cAMP	4,8	CRP	26,29	cAMP	CRP	CHEBI:17489	20468888	Chemical	Gene	protein|compound|START_ENTITY function|nsubj|protein function|advmod|END_ENTITY	The cAMP receptor protein CRP can function as an osmoregulator of transcription in Escherichia_coli .
19193643	0	cAMP	53,57	CRP	76,79	cAMP	CRP	CHEBI:17489	20468888	Chemical	Gene	Protein|compound|START_ENTITY structure|nmod|Protein asymmetry|nmod|structure asymmetry|appos|END_ENTITY	Profound asymmetry in the structure of the cAMP-free cAMP Receptor Protein -LRB- CRP -RRB- from Mycobacterium_tuberculosis .
21345179	0	cAMP	22,26	CRP	45,48	cAMP	CRP	CHEBI:17489	20468888	Chemical	Gene	protein|compound|START_ENTITY effects|nmod|protein effects|appos|END_ENTITY	Regulatory effects of cAMP receptor protein -LRB- CRP -RRB- on porin genes and its own gene in Yersinia_pestis .
2169605	0	cAMP	35,39	CRP	56,59	cAMP	CRP	CHEBI:17489	20468888	Chemical	Gene	the|nmod|START_ENTITY the|nmod|END_ENTITY	Characterization of the binding of cAMP and cGMP to the CRP * 598 mutant of the E. _ coli cAMP_receptor_protein .
25541491	0	cAMP	79,83	CRP	148,151	cAMP	CRP	CHEBI:17489	20468888	Chemical	Gene	Revisiting|nmod|START_ENTITY Lessons|csubj|Revisiting Lessons|nmod|form form|nmod|END_ENTITY	Revisiting the mechanism of activation of cyclic_AMP_receptor_protein -LRB- CRP -RRB- by cAMP in Escherichia_coli : Lessons from a subunit-crosslinked form of CRP .
25541491	0	cAMP	79,83	CRP	71,74	cAMP	CRP	CHEBI:17489	20468888	Chemical	Gene	Revisiting|nmod|START_ENTITY Revisiting|dobj|mechanism mechanism|appos|END_ENTITY	Revisiting the mechanism of activation of cyclic_AMP_receptor_protein -LRB- CRP -RRB- by cAMP in Escherichia_coli : Lessons from a subunit-crosslinked form of CRP .
25541491	5	cAMP	747,751	CRP	689,692	cAMP	CRP	CHEBI:17489	20468888	Chemical	Gene	absence|nmod|START_ENTITY activate|nmod|absence activate|nsubj|END_ENTITY	We demonstrate that CRP -LRB- cl -RRB- can activate transcription even in the absence of cAMP .
25913005	0	cAMP	0,4	CRP	23,26	cAMP	CRP	CHEBI:17489	20468888	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	cAMP receptor protein -LRB- CRP -RRB- - mediated resistance/tolerance in bacteria : mechanism and utilization in biotechnology .
25913005	0	cAMP	0,4	CRP	23,26	cAMP	CRP	CHEBI:17489	20468888	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	cAMP receptor protein -LRB- CRP -RRB- - mediated resistance/tolerance in bacteria : mechanism and utilization in biotechnology .
26442598	0	cAMP	79,83	CRP	112,115	cAMP	CRP	CHEBI:17489	20468888	Chemical	Gene	cyclic_AMP|appos|START_ENTITY cyclic_AMP|appos|END_ENTITY	Direct regulation of the natural competence regulator gene tfoX by cyclic_AMP -LRB- cAMP -RRB- and cAMP_receptor_protein -LRB- CRP -RRB- in Vibrios .
9264036	0	cAMP	4,8	CRP	0,3	cAMP	CRP	CHEBI:17489	1401	Chemical	Gene	complex|compound|START_ENTITY induces|nsubj|complex END_ENTITY|parataxis|induces	CRP : cAMP complex binding to the lac operator region induces a structural change in lac DNA .
9737718	0	cAMP	91,95	CTGF	34,38	cAMP	CTGF	CHEBI:17489	1490	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|expression expression|compound|END_ENTITY	Inhibition of TGF-beta-stimulated CTGF gene expression and anchorage-independent growth by cAMP identifies a CTGF-dependent restriction point in the cell cycle .
14684377	0	cAMP	23,27	CXCL12	6,12	cAMP	CXCL12	CHEBI:17489	6387	Chemical	Gene	production|compound|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	SDF-1 / CXCL12 regulates cAMP production and ion transport in intestinal epithelial cells via CXCR4 .
9973394	0	cAMP	0,4	CXCR4	56,61	cAMP	CXCR4	CHEBI:17489	7852	Chemical	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	cAMP up-regulates cell surface expression of lymphocyte CXCR4 : implications for chemotaxis and HIV-1_infection .
9029713	0	cAMP	55,59	CYP17	41,46	cAMP	CYP17	CHEBI:17489	281739(Tax:9913)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|gene gene|compound|END_ENTITY	Transcriptional regulation of the bovine CYP17 gene by cAMP .
12859982	0	cAMP	15,19	CYP1B1	37,43	cAMP	CYP1B1	CHEBI:17489	25426(Tax:10116)	Chemical	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	Cell selective cAMP induction of rat CYP1B1 in adrenal and testis cells .
15523052	0	cAMP	87,91	CYP1B1	107,113	cAMP	CYP1B1	CHEBI:17489	1545	Chemical	Gene	stimulation|compound|START_ENTITY stimulation|nmod|END_ENTITY	Steroidogenic_factor-1 interacts with cAMP_response_element-binding_protein to mediate cAMP stimulation of CYP1B1 via a far upstream enhancer .
1334085	0	cAMP	86,90	CYP21B	119,125	cAMP	CYP21B	CHEBI:17489	1589	Chemical	Gene	responsiveness|compound|START_ENTITY responsiveness|nmod|gene gene|compound|END_ENTITY	Purification and characterization of a transcription factor which appears to regulate cAMP responsiveness of the human CYP21B gene .
1645728	0	cAMP	64,68	CYP21B	97,103	cAMP	CYP21B	CHEBI:17489	1589	Chemical	Gene	responsiveness|compound|START_ENTITY responsiveness|nmod|gene gene|compound|END_ENTITY	Evidence that an adrenal-specific nuclear protein regulates the cAMP responsiveness of the human CYP21B -LRB- P450C21 -RRB- gene .
11012754	0	cAMP	142,146	Calcitonin_gene-related_peptide	0,31	cAMP	Calcitonin gene-related peptide	CHEBI:17489	12310(Tax:10090)	Chemical	Gene	pathway|compound|START_ENTITY mediated|nmod|pathway macrophages|acl|mediated inhibits|nsubj|macrophages inhibits|dep|END_ENTITY	Calcitonin_gene-related_peptide inhibits lipopolysaccharide-induced interleukin-12 release from mouse peritoneal macrophages , mediated by the cAMP pathway .
2537038	0	cAMP	42,46	Calcitonin_gene-related_peptide	0,31	cAMP	Calcitonin gene-related peptide	CHEBI:17489	24241(Tax:10116)	Chemical	Gene	increases|dobj|START_ENTITY increases|nsubj|END_ENTITY	Calcitonin_gene-related_peptide increases cAMP , tension , and rate in rat atria .
12939297	0	cAMP	19,23	Cdk4	41,45	cAMP	Cdk4	CHEBI:17489	1019	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Regulatory role of cAMP on expression of Cdk4 and p27 -LRB- Kip1 -RRB- by inhibiting phosphatidylinositol 3-kinase in corneal endothelial cells .
6319941	0	cAMP	42,46	Corticotropin_releasing_factor	0,30	cAMP	Corticotropin releasing factor	CHEBI:17489	1392	Chemical	Gene	formation|compound|START_ENTITY stimulates|dobj|formation stimulates|nsubj|END_ENTITY	Corticotropin_releasing_factor stimulates cAMP formation in pituitary corticotropic tumor cells .
21266205	0	cAMP	102,106	Creb	0,4	cAMP	Creb	CHEBI:17489	81646(Tax:10116)	Chemical	Gene	control|nmod|START_ENTITY cooperate|xcomp|control cooperate|nsubj|elements elements|compound|END_ENTITY	Creb and Sp/Kr ppel response elements cooperate to control rat TRH gene transcription in response to cAMP .
15541386	0	cAMP	111,115	Crp	0,3	cAMP	Crp	CHEBI:17489	20468888	Chemical	Gene	able|nmod|START_ENTITY CRP-FNR|amod|able factor|nmod|CRP-FNR factor|nsubj|END_ENTITY	Crp of Streptomyces_coelicolor is the third transcription factor of the large CRP-FNR superfamily able to bind cAMP .
21281420	0	cAMP	65,69	Crp	60,63	cAMP	Crp	CHEBI:17489	1044152(Tax:160488)	Chemical	Gene	system|compound|START_ENTITY exaptation|dep|system exaptation|nmod|protein protein|appos|END_ENTITY	Regulatory exaptation of the catabolite repression protein -LRB- Crp -RRB- - cAMP system in Pseudomonas_putida .
15196506	0	cAMP	27,31	DARPP-32	0,8	cAMP	DARPP-32	CHEBI:17489	84152	Chemical	Gene	signaling|compound|START_ENTITY END_ENTITY|nmod|signaling	DARPP-32 and modulation of cAMP signaling : involvement in motor control and levodopa-induced dyskinesia .
8239544	0	cAMP	13,17	E-cadherin	21,31	cAMP	E-cadherin	CHEBI:17489	999	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Influence of cAMP on E-cadherin expression and cell surface heparan sulfate proteoglycan synthesis in human breast_cancer cells .
7592673	0	cAMP	44,48	EL-4	59,63	cAMP	EL-4	CHEBI:17489	111979(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Activation of the interleukin-5 promoter by cAMP in murine EL-4 cells requires the GATA-3 and CLE0 elements .
16476738	0	cAMP	55,59	ENaC	46,50	cAMP	ENaC	CHEBI:17489	24768(Tax:10116)	Chemical	Gene	channel|nmod|START_ENTITY channel|appos|END_ENTITY	Stimulation of the epithelial sodium channel -LRB- ENaC -RRB- by cAMP involves putative ERK phosphorylation sites in the C termini of the channel 's beta - and gamma-subunit .
15855407	0	cAMP	50,54	EP2	108,111	cAMP	EP2	CHEBI:17489	5732	Chemical	Gene	protein|compound|START_ENTITY protein|nmod|activation activation|nmod|END_ENTITY	Differential regulation of phosphorylation of the cAMP response element-binding protein after activation of EP2 and EP4 prostanoid receptors by prostaglandin_E2 .
17427962	0	cAMP	125,129	EP2	103,106	cAMP	EP2	CHEBI:17489	5732	Chemical	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Prostaglandin_E2 induces vascular_endothelial_growth_factor secretion in prostate_cancer cells through EP2 receptor-mediated cAMP pathway .
17728378	7	cAMP	1074,1078	EP2	1061,1064	cAMP	EP2	CHEBI:17489	5732	Chemical	Gene	formation|compound|START_ENTITY mediates|dobj|formation mediates|nsubj|END_ENTITY	Pharmacological evidence obtained by using PGE2-selective analogs further demonstrates that EP2 mediates cAMP formation and cystogenesis .
18537828	0	cAMP	143,147	EP2	131,134	cAMP	EP2	CHEBI:17489	5732	Chemical	Gene	elevation|compound|START_ENTITY mediated|nmod|elevation mediated|nmod|END_ENTITY	Downregulation of protease-activated_receptor-1 in human lung fibroblasts is specifically mediated by the prostaglandin E receptor EP2 through cAMP elevation and protein kinase A .
18562016	0	cAMP	23,27	EP2	47,50	cAMP	EP2	CHEBI:17489	5732	Chemical	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Lipoic_acid stimulates cAMP production via the EP2 and EP4 prostanoid receptors and inhibits IFN_gamma synthesis and cellular cytotoxicity in NK cells .
19782748	0	cAMP	22,26	EP2	0,3	cAMP	EP2	CHEBI:17489	5732	Chemical	Gene	release|compound|START_ENTITY augmented|nsubjpass|release mediated|ccomp|augmented mediated|nsubj|receptor receptor|compound|END_ENTITY	EP2 receptor mediated cAMP release is augmented by PGF 2 alpha activation of the FP receptor via the calcium-calmodulin pathway .
20399827	0	cAMP	133,137	EP2	117,120	cAMP	EP2	CHEBI:17489	5732	Chemical	Gene	receptor|nmod|START_ENTITY receptor|compound|END_ENTITY	Expression profiling of cumulus cells reveals functional changes during ovulation and central roles of prostaglandin EP2 receptor in cAMP signaling .
9758211	0	cAMP	61,65	EP2	98,101	cAMP	EP2	CHEBI:17489	5732	Chemical	Gene	radioimmunoassay|nmod|START_ENTITY Use|nmod|radioimmunoassay generated|nsubj|Use generated|dep|END_ENTITY	Use of a semi-automated , robotic radioimmunoassay to measure cAMP generated by activation of DP - , EP2 - , and IP-prostaglandin receptors in human ocular and other cell types .
16246110	0	cAMP	48,52	EPAC	117,121	cAMP	EPAC	CHEBI:17489	10411	Chemical	Gene	START_ENTITY|acl|signalling signalling|nmod|protein protein|acl|activated activated|nmod|cAMP cAMP|appos|END_ENTITY	Microtubule-associated proteins -LRB- MAPs -RRB- regulate cAMP signalling through exchange protein directly activated by cAMP -LRB- EPAC -RRB- .
18728186	0	cAMP	19,23	EPAC	0,4	cAMP	EPAC	CHEBI:17489	10411	Chemical	Gene	control|compound|START_ENTITY allow|dobj|control allow|nsubj|END_ENTITY	EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation .
19210747	0	cAMP	52,56	EPAC	0,4	cAMP	EPAC	CHEBI:17489	10411	Chemical	Gene	actions|nmod|START_ENTITY transduce|dobj|actions transduce|nsubj|proteins proteins|compound|END_ENTITY	EPAC proteins transduce diverse cellular actions of cAMP .
25121519	0	cAMP	0,4	EPAC	88,92	cAMP	EPAC	CHEBI:17489	10411	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|pathway pathway|compound|END_ENTITY	cAMP regulates expression of the cyclic nucleotide transporter MRP4 -LRB- ABCC4 -RRB- through the EPAC pathway .
25372777	0	cAMP	18,22	EPAC	133,137	cAMP	EPAC	CHEBI:17489	59326(Tax:10116)	Chemical	Gene	Expression|nmod|START_ENTITY Expression|acl|Binding Binding|nmod|Proteins Proteins|compound|END_ENTITY	Expression of the cAMP Binding Protein EPAC1 in Thyroid_Tumors and Growth Regulation of Thyroid Cells and Thyroid_Carcinoma Cells by EPAC Proteins .
26151319	0	cAMP	190,194	EPAC	196,200	cAMP	EPAC	CHEBI:17489	10411	Chemical	Gene	Activated|nmod|START_ENTITY Identification|nmod|Activated Studies|dep|Identification Studies|appos|END_ENTITY	Structure-Activity Relationship Studies of Substituted 2 - -LRB- Isoxazol-3-yl -RRB- -2 - oxo-N ' - phenyl-acetohydrazonoyl_Cyanide Analogues : Identification of Potent Exchange Proteins Directly Activated by cAMP -LRB- EPAC -RRB- Antagonists .
26269639	0	cAMP	39,43	EPAC	45,49	cAMP	EPAC	CHEBI:17489	223864(Tax:10090)	Chemical	Gene	Activated|nmod|START_ENTITY Activated|appos|END_ENTITY	Exchange Protein Directly Activated by cAMP -LRB- EPAC -RRB- Regulates Neuronal Polarization through Rap1B .
25339598	0	cAMP	39,43	EPAC1	45,50	cAMP	EPAC1	CHEBI:17489	223864(Tax:10090)	Chemical	Gene	Activated|nmod|START_ENTITY Activated|appos|END_ENTITY	Exchange Protein Directly Activated by cAMP -LRB- EPAC1 -RRB- Modulates Regulatory T Cell-Mediated Immune Suppression .
25372777	0	cAMP	18,22	EPAC1	39,44	cAMP	EPAC1	CHEBI:17489	59326(Tax:10116)	Chemical	Gene	Expression|nmod|START_ENTITY Expression|acl|Binding Binding|dobj|END_ENTITY	Expression of the cAMP Binding Protein EPAC1 in Thyroid_Tumors and Growth Regulation of Thyroid Cells and Thyroid_Carcinoma Cells by EPAC Proteins .
25683912	0	cAMP	4,8	EPAC1	18,23	cAMP	EPAC1	CHEBI:17489	10411	Chemical	Gene	sensors|compound|START_ENTITY sensors|appos|END_ENTITY	The cAMP sensors , EPAC1 and EPAC2 , display distinct subcellular distributions despite sharing a common nuclear pore localisation signal .
10527544	0	cAMP	11,15	ERK	19,22	cAMP	ERK	CHEBI:17489	5594	Chemical	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	Effects of cAMP on ERK mitogen-activated protein kinase activity in hepatocytes do not parallel the bidirectional regulation of DNA synthesis .
11444827	0	cAMP	0,4	ERK	72,75	cAMP	ERK	CHEBI:17489	5594	Chemical	Gene	protection|compound|START_ENTITY induced|nsubj|protection induced|nmod|inhibition inhibition|compound|END_ENTITY	cAMP protection of pancreatic_cancer cells against apoptosis induced by ERK inhibition .
11641439	0	cAMP	116,120	ERK	240,243	cAMP	ERK	CHEBI:17489	5594	Chemical	Gene	phosphodiesterase|compound|START_ENTITY phosphorylation|nmod|phosphodiesterase kinase|dobj|phosphorylation kinase|nmod|cells cells|nmod|route route|appos|END_ENTITY	Phorbol_12-myristate_13-acetate triggers the protein kinase A-mediated phosphorylation and activation of the PDE4D5 cAMP phosphodiesterase in human aortic smooth muscle cells through a route involving extracellular signal regulated kinase -LRB- ERK -RRB- .
11897793	0	cAMP	65,69	ERK	43,46	cAMP	ERK	CHEBI:17489	24338(Tax:10116)	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Protein_kinase_A-independent activation of ERK and H,K-ATPase by cAMP in native kidney cells : role of Epac I .
16008550	0	cAMP	28,32	ERK	53,56	cAMP	ERK	CHEBI:17489	5594	Chemical	Gene	signals|nmod|START_ENTITY signals|parataxis|signalling signalling|nsubj|END_ENTITY	Integrating signals between cAMP and the RAS/RAF/MEK / ERK signalling pathways .
16030021	0	cAMP	61,65	ERK	223,226	cAMP	ERK	CHEBI:17489	5594	Chemical	Gene	phosphodiesterase|compound|START_ENTITY phosphodiesterase|acl|interacting interacting|xcomp|control control|dobj|switching switching|nmod|cells cells|amod|beta2-adrenergic_receptor beta2-adrenergic_receptor|nmod|activation activation|nmod|END_ENTITY	RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79-mediated switching of the beta2-adrenergic_receptor to activation of ERK in HEK293B2 cells .
17440132	0	cAMP	43,47	ERK	61,64	cAMP	ERK	CHEBI:17489	24338(Tax:10116)	Chemical	Gene	differentiation|nmod|START_ENTITY differentiation|acl|signaling signaling|xcomp|END_ENTITY	Regulation of PC12 cell differentiation by cAMP signaling to ERK independent of PKA : do all the connections add up ?
20015475	0	cAMP	27,31	ERK	143,146	cAMP	ERK	CHEBI:17489	5594	Chemical	Gene	protein|compound|START_ENTITY activates|dobj|protein activates|nmod|cells cells|nmod|pathway pathway|nmod|inhibition inhibition|nmod|END_ENTITY	Prostaglandin_E2 activates cAMP response element-binding protein in glioma cells via a signaling pathway involving PKA-dependent inhibition of ERK .
21750416	0	cAMP	0,4	ERK	53,56	cAMP	ERK	CHEBI:17489	5594	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|pathway pathway|nmod|END_ENTITY	cAMP induces autophagy via a novel pathway involving ERK , cyclin E and Beclin_1 .
21816215	0	cAMP	126,130	ERK	91,94	cAMP	ERK	CHEBI:17489	26413(Tax:10090)	Chemical	Gene	down-regulation|compound|START_ENTITY signaling|nmod|down-regulation chinensis|dep|signaling chinensis|nmod|END_ENTITY	Partially purified components of Nardostachys chinensis suppress melanin synthesis through ERK and Akt signaling pathway with cAMP down-regulation in B16F10 cells .
23261059	0	cAMP	134,138	ERK	159,162	cAMP	ERK	CHEBI:17489	26413(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of Caffeoylserotonin on inhibition of melanogenesis through the downregulation of MITF via the reduction of intracellular cAMP and acceleration of ERK activation in B16 murine melanoma cells .
23800469	0	cAMP	31,35	ERK	47,50	cAMP	ERK	CHEBI:17489	5594	Chemical	Gene	signals|compound|START_ENTITY connects|dobj|signals connects|nmod|activation activation|compound|END_ENTITY	Rapgef2 connects GPCR-mediated cAMP signals to ERK activation in neuronal and endocrine cells .
9514945	0	cAMP	0,4	ERK	28,31	cAMP	ERK	CHEBI:17489	26413(Tax:10090)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|compound|END_ENTITY	cAMP enhances CSF-1-induced ERK activity and c-fos mRNA expression via a MEK-dependent and Ras-independent mechanism in macrophages .
12297510	0	cAMP	47,51	ERK5	39,43	cAMP	ERK5	CHEBI:17489	23939(Tax:10090)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Cell condition-dependent regulation of ERK5 by cAMP .
9595415	0	cAMP	27,31	Endothelin-1	0,12	cAMP	Endothelin-1	CHEBI:17489	24323(Tax:10116)	Chemical	Gene	modulation|nmod|START_ENTITY modulation|amod|END_ENTITY	Endothelin-1 modulation of cAMP in rat pulmonary arteries : effect of chronic hypoxia .
14506476	0	cAMP	12,16	Epac	0,4	cAMP	Epac	CHEBI:17489	10411	Chemical	Gene	target|compound|START_ENTITY END_ENTITY|dep|target	Epac : a new cAMP target and new avenues in cAMP research .
15133061	0	cAMP	12,16	Epac	113,117	cAMP	Epac	CHEBI:17489	59326(Tax:10116)	Chemical	Gene	recruits|compound|START_ENTITY Exposure|nmod|recruits rat_chromaffin_cells|nsubj|Exposure rat_chromaffin_cells|nmod|proteins proteins|amod|END_ENTITY	Exposure to cAMP and beta-adrenergic stimulation recruits Ca -LRB- V -RRB- 3 T-type channels in rat_chromaffin_cells through Epac cAMP-receptor proteins .
15178699	0	cAMP	0,4	Epac	172,176	cAMP	Epac	CHEBI:17489	10411	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|activation activation|appos|END_ENTITY	cAMP protects neutrophils against TNF-alpha-induced apoptosis by activation of cAMP-dependent protein kinase , independently of exchange protein directly activated by cAMP -LRB- Epac -RRB- .
15178699	0	cAMP	166,170	Epac	172,176	cAMP	Epac	CHEBI:17489	10411	Chemical	Gene	activated|nmod|START_ENTITY protein|acl|activated activation|nmod|protein activation|appos|END_ENTITY	cAMP protects neutrophils against TNF-alpha-induced apoptosis by activation of cAMP-dependent protein kinase , independently of exchange protein directly activated by cAMP -LRB- Epac -RRB- .
15550931	0	cAMP	98,102	Epac	23,27	cAMP	Epac	CHEBI:17489	10411	Chemical	Gene	indicator|compound|START_ENTITY Epac|nmod|indicator activation|dep|Epac activation|amod|END_ENTITY	Detecting cAMP-induced Epac activation by fluorescence resonance energy transfer : Epac as a novel cAMP indicator .
15550931	0	cAMP	98,102	Epac	82,86	cAMP	Epac	CHEBI:17489	10411	Chemical	Gene	indicator|compound|START_ENTITY END_ENTITY|nmod|indicator	Detecting cAMP-induced Epac activation by fluorescence resonance energy transfer : Epac as a novel cAMP indicator .
16207818	0	cAMP	25,29	Epac	0,4	cAMP	Epac	CHEBI:17489	59326(Tax:10116)	Chemical	Gene	converts|dobj|START_ENTITY converts|nsubj|activation activation|amod|END_ENTITY	Epac activation converts cAMP from a proliferative into a differentiation signal in PC12 cells .
16613879	0	cAMP	0,4	Epac	12,16	cAMP	Epac	CHEBI:17489	10411	Chemical	Gene	sensor|nsubj|START_ENTITY sensor|dobj|END_ENTITY	cAMP sensor Epac as a determinant of ATP-sensitive potassium channel activity in human pancreatic beta cells and rat INS-1 cells .
16973695	0	cAMP	19,23	Epac	31,35	cAMP	Epac	CHEBI:17489	10411	Chemical	Gene	physiology|nmod|START_ENTITY sensor|nsubj|physiology sensor|dobj|END_ENTITY	Cell physiology of cAMP sensor Epac .
17084085	0	cAMP	29,33	Epac	0,4	cAMP	Epac	CHEBI:17489	10411	Chemical	Gene	targets|compound|START_ENTITY proteins|dep|targets proteins|amod|END_ENTITY	Epac proteins : multi-purpose cAMP targets .
17284589	0	cAMP	30,34	Epac	36,40	cAMP	Epac	CHEBI:17489	10411	Chemical	Gene	activated|nmod|START_ENTITY protein|acl|activated protein|appos|END_ENTITY	Exchange protein activated by cAMP -LRB- Epac -RRB- mediates cAMP activation of p38 MAPK and modulation of Ca2 + - dependent K + channels in cerebellar neurons .
17284589	0	cAMP	51,55	Epac	36,40	cAMP	Epac	CHEBI:17489	10411	Chemical	Gene	activation|compound|START_ENTITY mediates|dobj|activation mediates|nsubj|protein protein|appos|END_ENTITY	Exchange protein activated by cAMP -LRB- Epac -RRB- mediates cAMP activation of p38 MAPK and modulation of Ca2 + - dependent K + channels in cerebellar neurons .
17702820	0	cAMP	23,27	Epac	35,39	cAMP	Epac	CHEBI:17489	59326(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY sensor|nsubj|role sensor|dobj|END_ENTITY	A critical role of the cAMP sensor Epac in switching protein kinase signalling in prostaglandin_E2-induced potentiation of P2X3 receptor currents in inflamed rats .
18202100	0	cAMP	12,16	Epac	24,28	cAMP	Epac	CHEBI:17489	10411	Chemical	Gene	Role|nmod|START_ENTITY sensor|nsubj|Role sensor|ccomp|channel channel|nsubj|END_ENTITY	Role of the cAMP sensor Epac as a determinant of KATP channel ATP sensitivity in human pancreatic beta-cells and rat INS-1 cells .
18391018	0	cAMP	12,16	Epac	103,107	cAMP	Epac	CHEBI:17489	10411	Chemical	Gene	Cyclic_AMP|appos|START_ENTITY Cyclic_AMP|dep|stimulation stimulation|nmod|differentiation differentiation|acl:relcl|requires requires|dobj|action action|nmod|END_ENTITY	Cyclic_AMP -LRB- cAMP -RRB- - mediated stimulation of adipocyte differentiation requires the synergistic action of Epac - and cAMP-dependent protein kinase-dependent processes .
19065671	0	cAMP	4,8	Epac	19,23	cAMP	Epac	CHEBI:17489	59326(Tax:10116)	Chemical	Gene	effectors|nsubj|START_ENTITY effectors|ccomp|involved involved|nsubjpass|END_ENTITY	The cAMP effectors Epac and protein_kinase_a -LRB- PKA -RRB- are involved in the hepatic cystogenesis of an animal model of autosomal_recessive_polycystic_kidney_disease -LRB- ARPKD -RRB- .
19491242	0	cAMP	30,34	Epac	36,40	cAMP	Epac	CHEBI:17489	59326(Tax:10116)	Chemical	Gene	activated|nmod|START_ENTITY protein|acl|activated protein|appos|END_ENTITY	Exchange protein activated by cAMP -LRB- Epac -RRB- mediates cAMP-dependent but protein kinase A-insensitive modulation of vascular ATP-sensitive potassium channels .
19912228	0	cAMP	33,37	Epac	12,16	cAMP	Epac	CHEBI:17489	10411	Chemical	Gene	mediators|compound|START_ENTITY proteins|appos|mediators proteins|amod|END_ENTITY	The role of Epac proteins , novel cAMP mediators , in the regulation of immune , lung and neuronal function .
19962392	0	cAMP	97,101	Epac	45,49	cAMP	Epac	CHEBI:17489	10411	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Rac GTPase is a hub for protein kinase A and Epac signaling in endothelial barrier protection by cAMP .
20055708	0	cAMP	35,39	Epac	0,4	cAMP	Epac	CHEBI:17489	10411	Chemical	Gene	action|compound|START_ENTITY defining|nmod|action END_ENTITY|parataxis|defining	Epac : defining a new mechanism for cAMP action .
20428467	0	cAMP	69,73	Epac	149,153	cAMP	Epac	CHEBI:17489	10411	Chemical	Gene	analog|compound|START_ENTITY analog|amod|selective selective|nmod|END_ENTITY	Facilitation of - cell K -LRB- ATP -RRB- channel sulfonylurea sensitivity by a cAMP analog selective for the cAMP-regulated guanine_nucleotide exchange factor Epac .
21047789	0	cAMP	18,22	Epac	33,37	cAMP	Epac	CHEBI:17489	10411	Chemical	Gene	effectors|nsubj|START_ENTITY effectors|dobj|END_ENTITY	Radixin assembles cAMP effectors Epac and PKA into a functional cAMP compartment : role in cAMP-dependent cell proliferation .
21047789	0	cAMP	64,68	Epac	33,37	cAMP	Epac	CHEBI:17489	10411	Chemical	Gene	compartment|compound|START_ENTITY effectors|nmod|compartment effectors|dobj|END_ENTITY	Radixin assembles cAMP effectors Epac and PKA into a functional cAMP compartment : role in cAMP-dependent cell proliferation .
21402149	0	cAMP	11,15	Epac	26,30	cAMP	Epac	CHEBI:17489	10411	Chemical	Gene	START_ENTITY|acl|signaling signaling|dobj|proteins proteins|amod|END_ENTITY	Rap-linked cAMP signaling Epac proteins : compartmentation , functioning and disease implications .
21745194	0	cAMP	0,4	Epac	110,114	cAMP	Epac	CHEBI:17489	223864(Tax:10090)	Chemical	Gene	signalling|compound|START_ENTITY protects|nsubj|signalling protects|nmod|apoptosis apoptosis|nmod|activation activation|nmod|END_ENTITY	cAMP signalling protects proximal tubular epithelial cells from cisplatin-induced apoptosis via activation of Epac .
23523631	0	cAMP	0,4	Epac	110,114	cAMP	Epac	CHEBI:17489	10411	Chemical	Gene	signalling|compound|START_ENTITY decreases|nsubj|signalling decreases|advcl|promoting promoting|dobj|degradation degradation|nmod|END_ENTITY	cAMP signalling decreases p300 protein levels by promoting its ubiquitin/proteasome dependent degradation via Epac and p38 MAPK in lung_cancer cells .
23959673	0	cAMP	30,34	Epac	36,40	cAMP	Epac	CHEBI:17489	59326(Tax:10116)	Chemical	Gene	activated|nmod|START_ENTITY protein|acl|activated protein|appos|END_ENTITY	Exchange protein activated by cAMP -LRB- Epac -RRB- induces vascular relaxation by activating Ca2 + - sensitive K + channels in rat mesenteric artery .
24450633	0	cAMP	0,4	Epac	48,52	cAMP	Epac	CHEBI:17489	10411	Chemical	Gene	signalling|compound|START_ENTITY signalling|dep|role role|nmod|END_ENTITY	cAMP signalling in the vasculature : the role of Epac -LRB- exchange protein directly activated by cAMP -RRB- .
24450633	0	cAMP	93,97	Epac	48,52	cAMP	Epac	CHEBI:17489	10411	Chemical	Gene	activated|nmod|START_ENTITY protein|acl|activated END_ENTITY|dep|protein	cAMP signalling in the vasculature : the role of Epac -LRB- exchange protein directly activated by cAMP -RRB- .
24497631	0	cAMP	77,81	Epac	135,139	cAMP	Epac	CHEBI:17489	223864(Tax:10090)	Chemical	Gene	activity|amod|START_ENTITY activity|dep|implications implications|nmod|activation activation|amod|END_ENTITY	Identification and validation of modulators of exchange protein activated by cAMP -LRB- Epac -RRB- activity : structure-function implications for Epac activation and inhibition .
24497631	0	cAMP	77,81	Epac	83,87	cAMP	Epac	CHEBI:17489	223864(Tax:10090)	Chemical	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Identification and validation of modulators of exchange protein activated by cAMP -LRB- Epac -RRB- activity : structure-function implications for Epac activation and inhibition .
26589262	0	cAMP	0,4	Epac	51,55	cAMP	Epac	CHEBI:17489	10411	Chemical	Gene	effects|compound|START_ENTITY effects|dep|role role|nmod|END_ENTITY	cAMP effects in neuroendocrine_tumors : The role of Epac and PKA in cell proliferation and adhesion .
11237625	0	cAMP	23,27	Epac1	76,81	cAMP	Epac1	CHEBI:17489	10411	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Dynamic interaction of cAMP with the Rap guanine-nucleotide exchange factor Epac1 .
12819211	0	cAMP	0,4	Epac1	23,28	cAMP	Epac1	CHEBI:17489	59326(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|mapping mapping|nmod|END_ENTITY	cAMP analog mapping of Epac1 and cAMP kinase .
16728394	0	cAMP	64,68	Epac1	0,5	cAMP	Epac1	CHEBI:17489	10411	Chemical	Gene	affinity|compound|START_ENTITY have|dobj|affinity have|nsubj|END_ENTITY	Epac1 and cAMP-dependent protein kinase holoenzyme have similar cAMP affinity , but their cAMP domains have distinct structural features and cyclic nucleotide recognition .
22343288	0	cAMP	0,4	Epac1	85,90	cAMP	Epac1	CHEBI:17489	10411	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|DEP DEP|nmod|END_ENTITY	cAMP regulates DEP domain-mediated binding of the guanine_nucleotide exchange factor Epac1 to phosphatidic_acid at the plasma membrane .
21454623	0	cAMP	27,31	Epac2	39,44	cAMP	Epac2	CHEBI:17489	11069	Chemical	Gene	activation|compound|START_ENTITY activation|amod|END_ENTITY	Mechanism of intracellular cAMP sensor Epac2 activation : cAMP-induced conformational changes identified by amide_hydrogen / deuterium exchange mass spectrometry -LRB- DXMS -RRB- .
1311331	0	cAMP	35,39	Epidermal_growth_factor	0,23	cAMP	Epidermal growth factor	CHEBI:17489	25313(Tax:10116)	Chemical	Gene	accumulation|compound|START_ENTITY stimulates|dobj|accumulation stimulates|nsubj|END_ENTITY	Epidermal_growth_factor stimulates cAMP accumulation in cultured rat cardiac myocytes .
25500291	0	cAMP	43,47	Erythropoietin	0,14	cAMP	Erythropoietin	CHEBI:17489	13856(Tax:10090)	Chemical	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Erythropoietin activates the phosporylated cAMP -LSB- adenosine_3 ' 5 ' _ cyclic_monophosphate -RSB- response element-binding protein pathway and attenuates delayed paraplegia after ischemia-reperfusion injury .
25366423	0	cAMP	46,50	GPCR	33,37	cAMP	GPCR	CHEBI:17489	295589(Tax:10116)	Chemical	Gene	generation|compound|START_ENTITY generation|compound|END_ENTITY	CANDLES , an assay for monitoring GPCR induced cAMP generation in cell cultures .
7686773	0	cAMP	83,87	Gastrin	0,7	cAMP	Gastrin	CHEBI:17489	445524(Tax:9823)	Chemical	Gene	requires|dobj|START_ENTITY requires|nsubj|action action|compound|END_ENTITY	Gastrin action on aminopyrine accumulation in isolated pig parietal cells requires cAMP .
7840210	0	cAMP	30,34	Gastrin	0,7	cAMP	Gastrin	CHEBI:17489	445524(Tax:9823)	Chemical	Gene	require|dobj|START_ENTITY require|nsubj|END_ENTITY	Gastrin and carbachol require cAMP to elicit aminopyrine accumulation in isolated pig and rat parietal cells .
21170647	0	cAMP	67,71	Gc_protein-derived_macrophage-activating_factor	0,47	cAMP	Gc protein-derived macrophage-activating factor	CHEBI:17489	2638	Chemical	Gene	formation|compound|START_ENTITY stimulates|dobj|formation stimulates|nsubj|END_ENTITY	Gc_protein-derived_macrophage-activating_factor -LRB- GcMAF -RRB- stimulates cAMP formation in human mononuclear cells and inhibits angiogenesis in chick embryo chorionallantoic membrane assay .
12093801	0	cAMP	47,51	Glycogen_synthase_kinase_3beta	0,30	cAMP	Glycogen synthase kinase 3beta	CHEBI:17489	2932	Chemical	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	Glycogen_synthase_kinase_3beta is activated by cAMP and plays an active role in the regulation of melanogenesis .
7892191	0	cAMP	44,48	Growth_hormone-releasing_hormone	0,32	cAMP	Growth hormone-releasing hormone	CHEBI:17489	29446(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Growth_hormone-releasing_hormone stimulates cAMP release in superfused rat pituitary cells .
26553542	0	cAMP	77,81	HCN4	53,57	cAMP	HCN4	CHEBI:17489	10021	Chemical	Gene	sensitivity|compound|START_ENTITY sensitivity|compound|END_ENTITY	A gain-of-function mutation in the cardiac pacemaker HCN4 channel increasing cAMP sensitivity is associated with familial_Inappropriate_Sinus_Tachycardia .
23011923	0	cAMP	35,39	IGFBP-1	13,20	cAMP	IGFBP-1	CHEBI:17489	3484	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Induction of IGFBP-1 expression by cAMP is associated with histone acetylation status of the promoter region in human endometrial stromal cells .
24248464	0	cAMP	129,133	IGFBP-1	101,108	cAMP	IGFBP-1	CHEBI:17489	3484	Chemical	Gene	Importance|nmod|START_ENTITY Importance|nmod|END_ENTITY	Importance of C/EBPb binding and histone acetylation status in the promoter regions for induction of IGFBP-1 , PRL , and Mn-SOD by cAMP in human endometrial stromal cells .
19058854	0	cAMP	0,4	IL-10	15,20	cAMP	IL-10	CHEBI:17489	16153(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|compound|END_ENTITY	cAMP regulates IL-10 production by normal human T lymphocytes at multiple levels : a potential role for MEF2 .
2166109	0	cAMP	0,4	IL-2	19,23	cAMP	IL-2	CHEBI:17489	16183(Tax:10090)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	cAMP regulation of IL-2 receptor expression .
7819141	0	cAMP	0,4	IL-2	88,92	cAMP	IL-2	CHEBI:17489	16183(Tax:10090)	Chemical	Gene	START_ENTITY|advcl|decreasing decreasing|dobj|release release|compound|END_ENTITY	cAMP up-regulates IL-4 and IL-5 production from activated CD4 + T cells while decreasing IL-2 release and NF-AT induction .
12376407	0	cAMP	73,77	IL-6	46,50	cAMP	IL-6	CHEBI:17489	3569	Chemical	Gene	activated|nmod|START_ENTITY activated|nsubjpass|factors factors|acl|regulating regulating|dobj|gene gene|compound|END_ENTITY	Multiple transcription factors regulating the IL-6 gene are activated by cAMP in cultured Caco-2 cells .
16466739	0	cAMP	13,17	IL-6	81,85	cAMP	IL-6	CHEBI:17489	16193(Tax:10090)	Chemical	Gene	pathway|compound|START_ENTITY mediate|nsubj|pathway mediate|dobj|production production|compound|END_ENTITY	Noncanonical cAMP pathway and p38_MAPK mediate beta2-adrenergic receptor-induced IL-6 production in neonatal mouse cardiac fibroblasts .
17141199	0	cAMP	93,97	IL-6	63,67	cAMP	IL-6	CHEBI:17489	16193(Tax:10090)	Chemical	Gene	accumulation|compound|START_ENTITY inhibition|nmod|accumulation secretion|dep|inhibition secretion|compound|END_ENTITY	Phenylarsine_oxide inhibited beta-adrenergic receptor-mediated IL-6 secretion : inhibition of cAMP accumulation and CREB activation in cardiac fibroblasts .
17324158	0	cAMP	57,61	IL-6	76,80	cAMP	IL-6	CHEBI:17489	3569	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Transcriptome profile of dendritic cells during malaria : cAMP regulation of IL-6 .
18280640	0	cAMP	18,22	IL-6	70,74	cAMP	IL-6	CHEBI:17489	24498(Tax:10116)	Chemical	Gene	increases|amod|START_ENTITY expression|compound|increases expression|compound|END_ENTITY	Activation of the cAMP pathway synergistically increases IL-1-induced IL-6 gene expression in FRTL-5 thyroid cells : involvement of AP-1 transcription factors .
19194991	0	cAMP	106,110	IL-6	30,34	cAMP	IL-6	CHEBI:17489	16193(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|5 5|dep|expression expression|compound|END_ENTITY	5 ' - N-ethylcarboxamide induces IL-6 expression via MAPKs and NF-kappaB activation through Akt , Ca -LRB- 2 + -RRB- / PKC , cAMP signaling pathways in mouse embryonic stem cells .
19496170	0	cAMP	0,4	IL-6	40,44	cAMP	IL-6	CHEBI:17489	16193(Tax:10090)	Chemical	Gene	activation|compound|START_ENTITY stimulates|nsubj|activation stimulates|dobj|release release|compound|END_ENTITY	cAMP activation by PACAP/VIP stimulates IL-6 release and inhibits osteoblastic differentiation through VPAC2_receptor in osteoblastic MC3T3 cells .
24363043	0	cAMP	38,42	IL-6	92,96	cAMP	IL-6	CHEBI:17489	3569	Chemical	Gene	START_ENTITY|acl|signaling signaling|dobj|compartment compartment|acl:relcl|regulates regulates|dobj|expression expression|compound|END_ENTITY	Non-raft adenylyl_cyclase_2 defines a cAMP signaling compartment that selectively regulates IL-6 expression in airway smooth muscle cells : differential regulation of gene expression by AC isoforms .
8587236	0	cAMP	123,127	IL-8	22,26	cAMP	IL-8	CHEBI:17489	3576	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	Interleukin-1-induced IL-8 and IL-6 gene expression and production in human mesangial cells is differentially regulated by cAMP .
8906740	0	cAMP	45,49	IgE	14,17	cAMP	IgE	CHEBI:17489	3497	Chemical	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Regulation of IgE and cytokine production by cAMP : implications for extrinsic asthma .
1321613	0	cAMP	69,73	Insulin	0,7	cAMP	Insulin	CHEBI:17489	3630	Chemical	Gene	phosphodiesterase|compound|START_ENTITY phosphorylation|nmod|phosphodiesterase induced|dobj|phosphorylation induced|nsubj|END_ENTITY	Insulin induced phosphorylation and activation of the cGMP-inhibited cAMP phosphodiesterase in human platelets .
20404042	0	cAMP	35,39	Insulin	0,7	cAMP	Insulin	CHEBI:17489	3630	Chemical	Gene	accumulation|compound|START_ENTITY inhibits|dobj|accumulation inhibits|nsubj|END_ENTITY	Insulin inhibits human erythrocyte cAMP accumulation and ATP release : role of phosphodiesterase 3 and phosphoinositide_3-kinase .
3031673	0	cAMP	102,106	Insulin	0,7	cAMP	Insulin	CHEBI:17489	3630	Chemical	Gene	regulation|compound|START_ENTITY kinase|nmod|regulation protein|amod|kinase affinity|nmod|protein inhibition|dep|affinity inhibition|compound|END_ENTITY	Insulin inhibition of hepatic cAMP-dependent protein kinase : decreased affinity of protein kinase for cAMP and possible differential regulation of intrachain sites 1 and 2 .
12939297	0	cAMP	19,23	Kip1	54,58	cAMP	Kip1	CHEBI:17489	1027	Chemical	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Regulatory role of cAMP on expression of Cdk4 and p27 -LRB- Kip1 -RRB- by inhibiting phosphatidylinositol 3-kinase in corneal endothelial cells .
14766009	0	cAMP	4,8	LHbeta	36,42	cAMP	LHbeta	CHEBI:17489	25329(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	The cAMP signaling system regulates LHbeta gene expression : roles of early_growth_response_protein-1 , SP1_and_steroidogenic_factor-1 .
21406690	0	cAMP	14,18	LRP6	0,4	cAMP	LRP6	CHEBI:17489	4040	Chemical	Gene	generation|compound|START_ENTITY mediates|dobj|generation mediates|nsubj|END_ENTITY	LRP6 mediates cAMP generation by G protein-coupled receptors through regulating the membrane targeting of Ga -LRB- s -RRB- .
10516232	0	cAMP	54,58	Leptin	0,6	cAMP	Leptin	CHEBI:17489	25608(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY secretion|acl|induced inhibits|dobj|secretion inhibits|nsubj|END_ENTITY	Leptin inhibits insulin secretion induced by cellular cAMP in a pancreatic B cell line -LRB- INS-1 cells -RRB- .
19662684	0	cAMP	37,41	Leptin	0,6	cAMP	Leptin	CHEBI:17489	3952	Chemical	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	Leptin enhances growth inhibition by cAMP elevating agents through apoptosis of MDA-MB-231 breast_cancer cells .
23261059	0	cAMP	134,138	MITF	94,98	cAMP	MITF	CHEBI:17489	17342(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of Caffeoylserotonin on inhibition of melanogenesis through the downregulation of MITF via the reduction of intracellular cAMP and acceleration of ERK activation in B16 murine melanoma cells .
22090316	0	cAMP	14,18	MRP4	53,57	cAMP	MRP4	CHEBI:17489	239273(Tax:10090)	Chemical	Gene	Regulation|nmod|START_ENTITY homeostasis|nsubj|Regulation homeostasis|nmod|END_ENTITY	Regulation of cAMP homeostasis by the efflux protein MRP4 in cardiac myocytes .
22381067	0	cAMP	35,39	MRP4	0,4	cAMP	MRP4	CHEBI:17489	239273(Tax:10090)	Chemical	Gene	contraction|compound|START_ENTITY regulation|nmod|contraction END_ENTITY|nmod|regulation	MRP4 and CFTR in the regulation of cAMP and b-adrenergic contraction in cardiac myocytes .
25121519	0	cAMP	0,4	MRP4	63,67	cAMP	MRP4	CHEBI:17489	10257	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	cAMP regulates expression of the cyclic nucleotide transporter MRP4 -LRB- ABCC4 -RRB- through the EPAC pathway .
25762723	0	cAMP	34,38	MRP4	89,93	cAMP	MRP4	CHEBI:17489	10257	Chemical	Gene	START_ENTITY|nmod|complexes complexes|nmod|Multidrug_Resistance_Protein_4 Multidrug_Resistance_Protein_4|appos|END_ENTITY	Compartmentalized Accumulation of cAMP near complexes of Multidrug_Resistance_Protein_4 -LRB- MRP4 -RRB- and Cystic_Fibrosis_Transmembrane_Conductance_Regulator -LRB- CFTR -RRB- Contributes to Drug-induced Diarrhea .
25790437	0	cAMP	13,17	MRP4	98,102	cAMP	MRP4	CHEBI:17489	10257	Chemical	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Dual Role of cAMP in the Transcriptional Regulation of Multidrug_Resistance-Associated_Protein_4 -LRB- MRP4 -RRB- in Pancreatic_Adenocarcinoma Cell Lines .
25790437	0	cAMP	13,17	Multidrug_Resistance-Associated_Protein_4	55,96	cAMP	Multidrug Resistance-Associated Protein 4	CHEBI:17489	10257	Chemical	Gene	START_ENTITY|nmod|Regulation Regulation|nmod|END_ENTITY	Dual Role of cAMP in the Transcriptional Regulation of Multidrug_Resistance-Associated_Protein_4 -LRB- MRP4 -RRB- in Pancreatic_Adenocarcinoma Cell Lines .
15246972	0	cAMP	0,4	NF-kappaB	59,68	cAMP	NF-kappaB	CHEBI:17489	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|compound|END_ENTITY	cAMP targeting of p38_MAP_kinase inhibits thrombin-induced NF-kappaB activation and ICAM-1 expression in endothelial cells .
9022022	0	cAMP	74,78	NF-kappaB	93,102	cAMP	NF-kappaB	CHEBI:17489	18033(Tax:10090)	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	Overexpression of mitogen-activated protein kinase kinase kinase reversed cAMP inhibition of NF-kappaB in T cells .
8243641	0	cAMP	28,32	NF-kappa_B	14,24	cAMP	NF-kappa B	CHEBI:17489	4790	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of NF-kappa_B by cAMP in human myeloid cells .
9188860	0	cAMP	67,71	NF-kappa_B	125,135	cAMP	NF-kappa B	CHEBI:17489	4790	Chemical	Gene	signaling|compound|START_ENTITY apoptosis|nmod|signaling Regulation|nmod|apoptosis Regulation|dep|role role|nmod|END_ENTITY	Regulation of Fas-dependent activation-induced T cell apoptosis by cAMP signaling : a potential role for transcription factor NF-kappa_B .
16144963	0	cAMP	0,4	NKCC2	37,42	cAMP	NKCC2	CHEBI:17489	25065(Tax:10116)	Chemical	Gene	increases|compound|START_ENTITY surface|nsubj|increases surface|dobj|expression expression|nmod|END_ENTITY	cAMP increases surface expression of NKCC2 in rat thick ascending limbs : role of VAMP .
16144963	4	cAMP	378,382	NKCC2	394,399	cAMP	NKCC2	CHEBI:17489	25065(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	However , the mechanism by which cAMP stimulates NKCC2 in TALs is not clear .
19592485	0	cAMP	0,4	NKCC2	79,84	cAMP	NKCC2	CHEBI:17489	6557	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|exocytosis exocytosis|nmod|END_ENTITY	cAMP stimulates apical exocytosis of the renal Na -LRB- + -RRB- - K -LRB- + -RRB- -2 Cl -LRB- - -RRB- cotransporter NKCC2 in the thick ascending limb : role of protein kinase A .
18371380	0	cAMP	114,118	Neurofibromatosis-1	0,19	cAMP	Neurofibromatosis-1	CHEBI:17489	18015(Tax:10090)	Chemical	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Neurofibromatosis-1 regulates neuronal and glial cell differentiation from neuroglial progenitors in vivo by both cAMP - and Ras-dependent mechanisms .
2175442	0	cAMP	24,28	Neuropeptide_Y	0,14	cAMP	Neuropeptide Y	CHEBI:17489	100301542(Tax:9986)	Chemical	Gene	accumulation|compound|START_ENTITY inhibits|dobj|accumulation inhibits|nsubj|END_ENTITY	Neuropeptide_Y inhibits cAMP accumulation in renal proximal convoluted tubules .
2554289	0	cAMP	0,4	P450scc	15,22	cAMP	P450scc	CHEBI:17489	13070(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	cAMP regulates P450scc gene expression by a cycloheximide-insensitive mechanism in cultured mouse Leydig MA-10 cells .
10749688	0	cAMP	36,40	PDE4	31,35	cAMP	PDE4	CHEBI:17489	5141	Chemical	Gene	isoforms|compound|START_ENTITY isoforms|compound|END_ENTITY	Action of rolipram on specific PDE4 cAMP phosphodiesterase isoforms and on the phosphorylation of cAMP-response-element-binding_protein -LRB- CREB -RRB- and p38 mitogen-activated protein -LRB- MAP -RRB- kinase in U937 monocytic cells .
14641023	0	cAMP	53,57	PDE4	48,52	cAMP	PDE4	CHEBI:17489	5141	Chemical	Gene	phosphodiesterase|compound|START_ENTITY phosphodiesterase|compound|END_ENTITY	The role of ERK2 docking and phosphorylation of PDE4 cAMP phosphodiesterase isoforms in mediating cross-talk between the cAMP and ERK signalling pathways .
15905070	0	cAMP	86,90	PDE4	81,85	cAMP	PDE4	CHEBI:17489	5141	Chemical	Gene	isoforms|compound|START_ENTITY isoforms|compound|END_ENTITY	In resting COS1 cells a dominant negative approach shows that specific , anchored PDE4 cAMP phosphodiesterase isoforms gate the activation , by basal cyclic_AMP production , of AKAP-tethered protein kinase A type II located in the centrosomal region .
17155857	4	cAMP	665,669	PDE4	688,692	cAMP	PDE4	CHEBI:17489	5141	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	These drugs block the hydrolysis of cAMP via inhibition of PDE4 and are attractive candidates for novel anti-inflammatory drugs .
12107181	0	cAMP	117,121	PGC-1	16,21	cAMP	PGC-1	CHEBI:17489	10891	Chemical	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	The coactivator PGC-1 is involved in the regulation of the liver carnitine palmitoyltransferase I gene expression by cAMP in combination with HNF4_alpha and cAMP-response_element-binding_protein -LRB- CREB -RRB- .
7638171	0	cAMP	0,4	PHAS-I	127,133	cAMP	PHAS-I	CHEBI:17489	116636(Tax:10116)	Chemical	Gene	regulation|amod|START_ENTITY END_ENTITY|nsubj|regulation	cAMP - and rapamycin-sensitive regulation of the association of eukaryotic initiation factor 4E and the translational regulator PHAS-I in aortic smooth muscle cells .
26932583	0	cAMP	54,58	Parathyroid_Hormone	25,44	cAMP	Parathyroid Hormone	CHEBI:17489	5741	Chemical	Gene	START_ENTITY|nsubj|Mediated Mediated|compound|END_ENTITY	Small Molecule Inhibited Parathyroid_Hormone Mediated cAMP Response by N-Terminal Peptide Binding .
19127545	0	cAMP	105,109	Parathyroid_hormone	0,19	cAMP	Parathyroid hormone	CHEBI:17489	5741	Chemical	Gene	elements|compound|START_ENTITY mediated|nmod|elements mediated|nsubjpass|regulation regulation|amod|END_ENTITY	Parathyroid_hormone regulation of the human bone_sialoprotein gene transcription is mediated through two cAMP response elements .
22896038	0	cAMP	52,56	Parathyroid_hormone	0,19	cAMP	Parathyroid hormone	CHEBI:17489	19226(Tax:10090)	Chemical	Gene	accumulation|compound|START_ENTITY stimulates|dobj|accumulation stimulates|nsubj|END_ENTITY	Parathyroid_hormone stimulates juxtaglomerular cell cAMP accumulation without stimulating renin release .
8810350	0	cAMP	97,101	Parathyroid_hormone	0,19	cAMP	Parathyroid hormone	CHEBI:17489	5741	Chemical	Gene	element|compound|START_ENTITY induces|nmod|element induces|nsubj|END_ENTITY	Parathyroid_hormone induces c-fos promoter activity in osteoblastic cells through phosphorylated cAMP response element -LRB- CRE -RRB- - binding protein binding to the major CRE .
8384793	0	cAMP	46,50	Parathyroid_hormone-related_protein	0,35	cAMP	Parathyroid hormone-related protein	CHEBI:17489	24695(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY increases|dobj|production increases|nsubj|END_ENTITY	Parathyroid_hormone-related_protein increases cAMP production in mammary epithelial cells .
7912096	0	cAMP	59,63	Pituitary_adenylate_cyclase-activating_polypeptide	0,50	cAMP	Pituitary adenylate cyclase-activating polypeptide	CHEBI:17489	11516(Tax:10090)	Chemical	Gene	production|compound|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Pituitary_adenylate_cyclase-activating_polypeptide induces cAMP production independently from vasoactive_intestinal_polypeptide in osteoblast-like cells .
8383449	0	cAMP	58,62	Protein_kinase_C	0,16	cAMP	Protein kinase C	CHEBI:17489	24681(Tax:10116)	Chemical	Gene	accumulation|compound|START_ENTITY inhibits|dobj|accumulation inhibits|nsubj|END_ENTITY	Protein_kinase_C inhibits arginine_vasopressin-stimulated cAMP accumulation via a Gi-dependent mechanism .
12082090	0	cAMP	26,30	RAP1	48,52	cAMP	RAP1	CHEBI:17489	5906	Chemical	Gene	stimulation|nmod|START_ENTITY require|nsubj|stimulation require|xcomp|kinases kinases|nsubj|END_ENTITY	MAP kinase stimulation by cAMP does not require RAP1 but SRC family kinases .
12621056	0	cAMP	53,57	RIalpha	127,134	cAMP	RIalpha	CHEBI:17489	19084(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	A winged helix forkhead -LRB- FOXD2 -RRB- tunes sensitivity to cAMP in T lymphocytes through regulation of cAMP-dependent protein kinase RIalpha .
16569707	0	cAMP	58,62	RXFP1	33,38	cAMP	RXFP1	CHEBI:17489	59350	Chemical	Gene	modulate|dobj|START_ENTITY modulate|nsubj|END_ENTITY	Relaxin family peptide receptors RXFP1 and RXFP2 modulate cAMP signaling by distinct mechanisms .
7694367	0	cAMP	14,18	Raf	50,53	cAMP	Raf	CHEBI:17489	22882	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition by cAMP of Ras-dependent activation of Raf .
11804588	0	cAMP	36,40	Rap1	73,77	cAMP	Rap1	CHEBI:17489	109905(Tax:10090)	Chemical	Gene	inhibition|nmod:poss|START_ENTITY inhibition|nmod|growth growth|nmod|END_ENTITY	PKA phosphorylation of Src mediates cAMP 's inhibition of cell growth via Rap1 .
12402047	0	cAMP	22,26	Rap1	75,79	cAMP	Rap1	CHEBI:17489	5906	Chemical	Gene	analogue|compound|START_ENTITY demonstrates|nsubj|analogue demonstrates|dobj|regulation regulation|nmod|END_ENTITY	A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK .
12873387	0	cAMP	13,17	Rap1	0,4	cAMP	Rap1	CHEBI:17489	109905(Tax:10090)	Chemical	Gene	couples|dobj|START_ENTITY couples|nsubj|END_ENTITY	Rap1 couples cAMP signaling to a distinct pool of p42/44MAPK regulating excitability , synaptic plasticity , learning , and memory .
22532442	7	cAMP	1267,1271	Rap1	1348,1352	cAMP	CREB	CHEBI:17489	1385	Chemical	Gene	START_ENTITY|dep|-2 -2|dep|O-Me-cAMP O-Me-cAMP|acl|activated activated|dobj|END_ENTITY	The exchange protein activated by cAMP -LRB- Epac -RRB- - selective 8 - -LRB- 4-chlorophenylthio -RRB- -2 ' - O-Me-cAMP -LRB- 100-500 M -RRB- activated Rap1 without affecting the other cAMP-dependent processes .
20028978	0	cAMP	108,112	Rv3676	50,56	cAMP	Rv3676	CHEBI:17489	885502(Tax:83332)	Chemical	Gene	differs|nmod|START_ENTITY differs|nsubj|protein protein|appos|END_ENTITY	Mycobacterium_tuberculosis cAMP receptor protein -LRB- Rv3676 -RRB- differs from the Escherichia_coli paradigm in its cAMP binding and DNA binding properties and transcription activation properties .
20028978	0	cAMP	27,31	Rv3676	50,56	cAMP	Rv3676	CHEBI:17489	885502(Tax:83332)	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Mycobacterium_tuberculosis cAMP receptor protein -LRB- Rv3676 -RRB- differs from the Escherichia_coli paradigm in its cAMP binding and DNA binding properties and transcription activation properties .
12234600	0	cAMP	24,28	S-adenosyl-homocysteine_hydrolase	54,87	cAMP	S-adenosyl-homocysteine hydrolase	CHEBI:17489	508158(Tax:9913)	Chemical	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Characterization of the cAMP binding site of purified S-adenosyl-homocysteine_hydrolase from bovine kidney .
7701543	0	cAMP	89,93	SBP	115,118	cAMP	SBP	CHEBI:17489	8991	Chemical	Gene	START_ENTITY|nmod|cells cells|nmod|END_ENTITY	The receptor-mediated action of sex_steroid_binding_protein -LRB- SBP , SHBG -RRB- : accumulation of cAMP in MCF-7 cells under SBP and estradiol treatment .
22462548	0	cAMP	45,49	SIK2	24,28	cAMP	SIK2	CHEBI:17489	23235	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	The AMPK-related kinase SIK2 is regulated by cAMP via phosphorylation at Ser358 in adipocytes .
9486201	0	cAMP	52,56	SP-A1	27,32	cAMP	SP-A1	CHEBI:17489	653509	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|genes genes|compound|END_ENTITY	Differential regulation of SP-A1 and SP-A2 genes by cAMP , glucocorticoids , and insulin .
8770068	0	cAMP	46,50	SP-A2	71,76	cAMP	SP-A2	CHEBI:17489	729238	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|gene gene|compound|END_ENTITY	A CRE-like element plays an essential role in cAMP regulation of human SP-A2 gene in alveolar type II cells .
21549693	0	cAMP	18,22	ST1936	0,6	cAMP	ST1936	CHEBI:17489	1459995(Tax:273063)	Chemical	Gene	stimulates|dobj|START_ENTITY stimulates|nsubj|END_ENTITY	ST1936 stimulates cAMP , Ca2 + , ERK1/2 and Fyn kinase through a full activation of cloned human 5-HT6 receptors .
9920804	0	cAMP	34,38	STC-1	42,47	cAMP	STC-1	CHEBI:17489	6781	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Activation of calcium channels by cAMP in STC-1 cells is dependent upon Ca2 + calmodulin-dependent protein kinase II .
23332756	0	cAMP	98,102	Sonic_hedgehog	71,85	cAMP	Sonic hedgehog	CHEBI:17489	20423(Tax:10090)	Chemical	Gene	pathway|nmod|START_ENTITY pathway|compound|END_ENTITY	The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic_hedgehog pathway via cAMP signaling .
11196415	0	cAMP	113,117	StAR	52,56	cAMP	StAR	CHEBI:17489	6770	Chemical	Gene	encoding|nmod|START_ENTITY encoding|dobj|protein protein|compound|END_ENTITY	Transcriptional regulation of the gene encoding the StAR protein in the human adrenocortical cell line , H295R by cAMP and TGFbeta1 .
11773448	12	cAMP	2501,2505	StAR	2589,2593	cAMP	CREB	CHEBI:17489	12912(Tax:10090)	Chemical	Gene	diminished|nsubj|START_ENTITY diminished|nmod|activity activity|compound|END_ENTITY	We also demonstrate that the inducible cAMP early repressor markedly diminished the endogenous effects of CREM on cAMP-induced StAR promoter activity and on StAR mRNA expression .
21147196	0	cAMP	0,4	StAR	20,24	cAMP	StAR	CHEBI:17489	6770	Chemical	Gene	stimulation|compound|START_ENTITY stimulation|nmod|expression expression|amod|END_ENTITY	cAMP stimulation of StAR expression and cholesterol metabolism is modulated by co-expression of labile suppressors of transcription and mRNA turnover .
25662274	0	cAMP	34,38	StAR	15,19	cAMP	StAR	CHEBI:17489	20845(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Stimulation of StAR expression by cAMP is controlled by inhibition of highly inducible SIK1 via CRTC2 , a co-activator of CREB .
12200113	0	cAMP	31,35	TNF-alpha	49,58	cAMP	TNF-alpha	CHEBI:17489	24835(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|production production|amod|END_ENTITY	Role of angiotensin_II-induced cAMP in mesangial TNF-alpha production .
14680506	0	cAMP	18,22	TNF-alpha	44,53	cAMP	TNF-alpha	CHEBI:17489	7124	Chemical	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Impact of VIP and cAMP on the regulation of TNF-alpha and IL-10 production : implications for rheumatoid_arthritis .
19531803	0	cAMP	66,70	TNF-alpha	27,36	cAMP	TNF-alpha	CHEBI:17489	7124	Chemical	Gene	macrophages|nmod|START_ENTITY production|nmod|macrophages production|amod|END_ENTITY	Suppression of LPS-induced TNF-alpha production in macrophages by cAMP is mediated by PKA-AKAP95-p105 .
20824160	0	cAMP	9,13	TNF-alpha	23,32	cAMP	TNF-alpha	CHEBI:17489	280943(Tax:9913)	Chemical	Gene	opposes|compound|START_ENTITY opposes|appos|END_ENTITY	Elevated cAMP opposes -LRB- TNF-alpha -RRB- - induced loss in the barrier integrity of corneal endothelium .
2161201	0	cAMP	57,61	TNF-alpha	20,29	cAMP	TNF-alpha	CHEBI:17489	7124	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|regulation regulation|amod|END_ENTITY	Cytotoxic effect of TNF-alpha and abnormal regulation of cAMP in the retinoid resistant cell line U937/GTB .
7683159	0	cAMP	0,4	TNF-alpha	129,138	cAMP	TNF-alpha	CHEBI:17489	7124	Chemical	Gene	stimulates|compound|START_ENTITY human_immunodeficiency_virus|nsubj|stimulates human_immunodeficiency_virus|parataxis|synergism synergism|nmod|END_ENTITY	cAMP stimulates human_immunodeficiency_virus _ -LRB- HIV-1 -RRB- from latently infected cells of monocyte-macrophage lineage : synergism with TNF-alpha .
9886984	0	cAMP	39,43	TNF-alpha	74,83	cAMP	TNF-alpha	CHEBI:17489	24835(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY dissociates|dobj|production dissociates|nmod|inhibition inhibition|nmod|production production|amod|END_ENTITY	Ethanol dissociates hormone-stimulated cAMP production from inhibition of TNF-alpha production in rat Kupffer cells .
11701462	0	cAMP	54,58	Thrombin	0,8	cAMP	Thrombin	CHEBI:17489	2147	Chemical	Gene	element|compound|START_ENTITY induces|nmod|element induces|nsubj|END_ENTITY	Thrombin induces interleukin-6 expression through the cAMP response element in vascular smooth muscle cells .
1312715	0	cAMP	34,38	Thrombomodulin	0,14	cAMP	Thrombomodulin	CHEBI:17489	7056	Chemical	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	Thrombomodulin gene regulation by cAMP and retinoic_acid in F9 embryonal_carcinoma cells .
11029551	0	cAMP	80,84	VIP	0,3	cAMP	VIP	CHEBI:17489	396323(Tax:9031)	Chemical	Gene	differentiation|nmod|START_ENTITY enhances|dobj|differentiation enhances|nsubj|END_ENTITY	VIP enhances the differentiation of retinal_pigment_epithelium in culture : from cAMP and pp60 -LRB- c-src -RRB- to melanogenesis and development of fluid transport capacity .
11530947	7	cAMP	1011,1015	VIP	940,943	cAMP	VIP	CHEBI:17489	100735454	Chemical	Gene	cyclic_AMP|appos|START_ENTITY likely|nmod|cyclic_AMP signaling|dep|likely stimulates|xcomp|signaling stimulates|nsubj|END_ENTITY	VIP stimulates cortisol production most likely through the cyclic_AMP -LRB- cAMP -RRB- signaling pathway .
11917175	0	cAMP	19,23	VIP	0,3	cAMP	VIP	CHEBI:17489	100352512(Tax:9986)	Chemical	Gene	production|compound|START_ENTITY stimulation|nmod|production stimulation|compound|END_ENTITY	VIP stimulation of cAMP production in corneal endothelial cells in tissue and organ cultures .
12409212	0	cAMP	78,82	VIP	13,16	cAMP	VIP	CHEBI:17489	100303697(Tax:9103)	Chemical	Gene	messenger|compound|START_ENTITY role|nmod|messenger Influence|dep|role Influence|nmod|END_ENTITY	Influence of VIP on prolactinemia in turkey anterior pituitary cells : role of cAMP second messenger in VIP-induced prolactin gene expression .
1329741	0	cAMP	94,98	VIP	61,64	cAMP	VIP	CHEBI:17489	117064(Tax:10116)	Chemical	Gene	distribution|dep|START_ENTITY distribution|nmod|peptides peptides|appos|END_ENTITY	Organ distribution and characterization of porcine peptides -LRB- VIP , CGRP and PHI -RRB- that increase cAMP in rat platelets .
1372240	3	cAMP	572,576	VIP	612,615	cAMP	VIP	CHEBI:17489	117064(Tax:10116)	Chemical	Gene	increased|nsubj|START_ENTITY increased|nmod|infusion infusion|compound|END_ENTITY	When VIP was perfused at 10 -LRB- -8 -RRB- M or more , glucose output increased dose dependently , whereas cAMP increased only a little during the VIP infusion , but increased greatly after the infusion .
1667418	0	cAMP	77,81	VIP	48,51	cAMP	VIP	CHEBI:17489	7432	Chemical	Gene	START_ENTITY|nsubj|peptide peptide|appos|END_ENTITY	Suramin inhibits vasoactive intestinal peptide -LRB- VIP -RRB- binding and VIP-induced cAMP accumulation into two human cancerous cell lines .
17462790	0	cAMP	41,45	VIP	8,11	cAMP	VIP	CHEBI:17489	7432	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|xcomp|signaling	A novel VIP signaling pathway in T cells cAMP -- > protein tyrosine phosphatase -LRB- SHP-2 ? -RRB-
18299998	0	cAMP	29,33	VIP	108,111	cAMP	VIP	CHEBI:17489	22353(Tax:10090)	Chemical	Gene	response|compound|START_ENTITY Expression|nmod|response Expression|dobj|protein protein|nmod|pathways pathways|nmod|END_ENTITY	Expression of phosphorylated cAMP response element binding protein -LRB- p-CREB -RRB- in bladder afferent pathways in VIP - / - mice with cyclophosphamide -LRB- CYP -RRB- - induced cystitis .
2425626	0	cAMP	0,4	VIP	58,61	cAMP	VIP	CHEBI:17489	484038(Tax:9615)	Chemical	Gene	provides|nsubj|START_ENTITY provides|dobj|evidence evidence|nmod|receptors receptors|compound|END_ENTITY	cAMP immunocytochemistry provides evidence for functional VIP receptors in trachea .
2538331	2	cAMP	137,141	VIP	130,133	cAMP	VIP	CHEBI:17489	7432	Chemical	Gene	production|compound|START_ENTITY Effect|nmod|production Effect|nmod|END_ENTITY	Effect of VIP on cAMP production and on cell-surface VIP-binding sites .
38409	0	cAMP	120,124	VIP	91,94	cAMP	VIP	CHEBI:17489	117064(Tax:10116)	Chemical	Gene	formation|nmod|START_ENTITY stimulated|dobj|formation Effect|acl|stimulated Effect|appos|END_ENTITY	Effect of kainic_acid injections and other brain_lesions on vasoactive intestinal peptide -LRB- VIP -RRB- - stimulated formation of cAMP in rat brain .
6206481	0	cAMP	34,38	VIP	0,3	cAMP	VIP	CHEBI:17489	7432	Chemical	Gene	levels|appos|START_ENTITY elevates|dobj|levels elevates|nsubj|END_ENTITY	VIP elevates platelet cyclic_AMP -LRB- cAMP -RRB- levels and inhibits in vitro platelet activation induced by platelet-activating factor -LRB- PAF -RRB- .
7521755	0	cAMP	133,137	VIP	31,34	cAMP	VIP	CHEBI:17489	117064(Tax:10116)	Chemical	Gene	involves|dobj|START_ENTITY mechanism|acl:relcl|involves inhibits|nmod|mechanism inhibits|nsubj|peptide peptide|appos|END_ENTITY	Vasoactive intestinal peptide -LRB- VIP -RRB- inhibits substrate adherence capacity of rat peritoneal macrophages by a mechanism that involves cAMP .
8127414	0	cAMP	21,25	VIP	127,130	cAMP	VIP	CHEBI:17489	117064(Tax:10116)	Chemical	Gene	accumulation|compound|START_ENTITY accumulation|nmod|nuclei nuclei|nmod|rats rats|nmod|microinjections microinjections|nmod|vasoactive_intestinal_polypeptide vasoactive_intestinal_polypeptide|appos|END_ENTITY	Rapid alterations in cAMP accumulation in brain nuclei of rats following microinjections of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- into the lateral ventricle .
8752106	3	cAMP	602,606	VIP	595,598	cAMP	VIP	CHEBI:17489	22353(Tax:10090)	Chemical	Gene	accumulation|compound|START_ENTITY END_ENTITY|nmod|accumulation	The effect of VIP on cAMP accumulation was less potent .
8957233	0	cAMP	126,130	VIP	26,29	cAMP	VIP	CHEBI:17489	7432	Chemical	Gene	role|nmod|START_ENTITY modulation|dep|role modulation|nmod|END_ENTITY	Presynaptic modulation by VIP , secretin and isoproterenol of somatostatin release from enriched enteric synaptosomes : role of cAMP .
9016768	0	cAMP	121,125	VIP	90,93	cAMP	VIP	CHEBI:17489	7432	Chemical	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	Aspartate 196 in the first extracellular loop of the human VIP1 receptor is essential for VIP binding and VIP-stimulated cAMP production .
9651211	2	cAMP	342,346	VIP	311,314	cAMP	VIP	CHEBI:17489	117064(Tax:10116)	Chemical	Gene	element|compound|START_ENTITY contains|dobj|element contains|nsubj|gene gene|compound|END_ENTITY	Because the VIP gene contains a functional cAMP response element , the effects of cAMP-elevating agents on VIP expression were examined .
7594884	7	cAMP	1606,1610	activin	1746,1753	cAMP	activin	CHEBI:17489	83729	Chemical	Gene	accumulation|compound|START_ENTITY increase|dobj|accumulation examined|advcl|increase examined|dobj|effect effect|nmod|END_ENTITY	Since activin alone did not increase intracellular cAMP accumulation , to further clarify the role of activin and cAMP in the induction of FSH receptors , we examined the interactive effect of activin with cAMP on the induction of FSH receptors on cultured rat granulosa cells by 125I-FSH binding analysis .
7594884	7	cAMP	1759,1763	activin	1746,1753	cAMP	activin	CHEBI:17489	83729	Chemical	Gene	examined|nmod|START_ENTITY examined|dobj|effect effect|nmod|END_ENTITY	Since activin alone did not increase intracellular cAMP accumulation , to further clarify the role of activin and cAMP in the induction of FSH receptors , we examined the interactive effect of activin with cAMP on the induction of FSH receptors on cultured rat granulosa cells by 125I-FSH binding analysis .
8143789	0	cAMP	24,28	activin	86,93	cAMP	activin	CHEBI:17489	83729	Chemical	Gene	action|nmod|START_ENTITY action|nmod|END_ENTITY	Combinatorial action of cAMP and phorbol_ester on synergistic expression of the human activin A gene .
23889134	0	cAMP	97,101	adenylate_cyclase_2	77,96	cAMP	adenylate cyclase 2	CHEBI:17489	108	Chemical	Gene	complex|compound|START_ENTITY complex|amod|END_ENTITY	AKAP79 , PKC , PKA and PDE4 participate in a Gq-linked muscarinic receptor and adenylate_cyclase_2 cAMP signalling complex .
9328930	0	cAMP	84,88	adrenomedullin	26,40	cAMP	adrenomedullin	CHEBI:17489	25026(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY effects|dep|role effects|nmod|END_ENTITY	Cytoprotective effects of adrenomedullin in glomerular cell injury : central role of cAMP signaling pathway .
10465513	0	cAMP	69,73	alpha-MSH	33,42	cAMP	alpha-MSH	CHEBI:17489	24664(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY Effects|nmod|levels Effects|nmod|END_ENTITY	Effects and interactions between alpha-MSH and MCH/NEI upon striatal cAMP levels .
10999953	0	cAMP	76,80	alpha2C-adrenergic_receptor	45,72	cAMP	alpha2C-adrenergic receptor	CHEBI:17489	152	Chemical	Gene	down-regulation|nmod|START_ENTITY down-regulation|nmod|END_ENTITY	Transcriptional down-regulation of the human alpha2C-adrenergic_receptor by cAMP .
2851330	0	cAMP	0,4	androgen_receptor	53,70	cAMP	androgen receptor	CHEBI:17489	11835(Tax:10090)	Chemical	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	cAMP binds with high affinity and specificity to the androgen_receptor from murine skeletal muscle .
26268270	0	cAMP	32,36	angiotensin_II	75,89	cAMP	angiotensin II	CHEBI:17489	24179(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY augmentation|nmod|phosphorylation mediates|nsubj|augmentation mediates|dobj|stimulation stimulation|amod|END_ENTITY	PKC-a-dependent augmentation of cAMP and CREB phosphorylation mediates the angiotensin_II stimulation of renin in the collecting_duct .
8858983	0	cAMP	71,75	angiotensin_II	25,39	cAMP	angiotensin II	CHEBI:17489	24179(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY END_ENTITY|nmod|release	The inhibitory effect of angiotensin_II on stimulus-induced release of cAMP is augmented in the genetically hypertensive rat kidney .
8941720	0	cAMP	11,15	angiotensin_II	53,67	cAMP	angiotensin II	CHEBI:17489	183	Chemical	Gene	antagonizes|nsubj|START_ENTITY antagonizes|nmod|END_ENTITY	Increasing cAMP antagonizes hypertrophic response to angiotensin_II without affecting Ras and MAP kinase activation in vascular smooth muscle cells .
9765341	0	cAMP	54,58	angiotensin_II	14,28	cAMP	angiotensin II	CHEBI:17489	24179(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	Modulation by angiotensin_II of isoproterenol-induced cAMP production in preglomerular microvascular smooth muscle cells from normotensive and genetically hypertensive rats .
8986458	0	cAMP	19,23	angiotensin_II_type_2_receptor	27,57	cAMP	angiotensin II type 2 receptor	CHEBI:17489	24182(Tax:10116)	Chemical	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|nmod|expression expression|amod|END_ENTITY	Down-regulation by cAMP of angiotensin_II_type_2_receptor gene expression in PC12 cells .
11121103	0	cAMP	51,55	annexin_A1	26,36	cAMP	annexin A1	CHEBI:17489	16952(Tax:10090)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	CREB is involved in mouse annexin_A1 regulation by cAMP and glucocorticoids .
26503226	0	cAMP	38,42	arginine_vasopressin	76,96	cAMP	arginine vasopressin	CHEBI:17489	24221(Tax:10116)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|transcription transcription|compound|END_ENTITY	Transcription factor CREB3L1 mediates cAMP and glucocorticoid regulation of arginine_vasopressin gene transcription in the rat hypothalamus .
18840401	0	cAMP	35,39	argininosuccinate_synthetase	70,98	cAMP	argininosuccinate synthetase	CHEBI:17489	445	Chemical	Gene	element|compound|START_ENTITY Identification|nmod|element Identification|nmod|gene gene|compound|END_ENTITY	Identification of a liver-specific cAMP response element in the human argininosuccinate_synthetase gene .
14575881	0	cAMP	39,43	arylalkylamine_N-acetyltransferase	170,204	cAMP	arylalkylamine N-acetyltransferase	CHEBI:17489	396066(Tax:9031)	Chemical	Gene	level|compound|START_ENTITY rhythm|nmod|level rhythm|dep|mechanism mechanism|acl|coupling coupling|nmod|enzyme enzyme|appos|END_ENTITY	Circadian rhythm and photic control of cAMP level in chick retinal cell cultures : a mechanism for coupling the circadian oscillator to the melatonin-synthesizing enzyme , arylalkylamine_N-acetyltransferase , in photoreceptor cells .
16207298	0	cAMP	104,108	arylalkylamine_N-acetyltransferase	25,59	cAMP	arylalkylamine N-acetyltransferase	CHEBI:17489	396066(Tax:9031)	Chemical	Gene	proteolysis|compound|START_ENTITY role|nmod|proteolysis regulation|dep|role regulation|nmod|activity activity|amod|END_ENTITY	UV-A light regulation of arylalkylamine_N-acetyltransferase activity in the chick pineal gland : role of cAMP and proteasomal proteolysis .
3026514	0	cAMP	51,55	beta-endorphin	11,25	cAMP	beta-endorphin	CHEBI:17489	5443	Chemical	Gene	level|compound|START_ENTITY Effect|nmod|level Effect|nmod|END_ENTITY	-LSB- Effect of beta-endorphin and myelopeptides on the cAMP level and proliferation of lymphocytes in vitro -RSB- .
9194931	0	cAMP	12,16	beta-endorphin	38,52	cAMP	beta-endorphin	CHEBI:17489	5443	Chemical	Gene	role|nmod|START_ENTITY role|nmod|release release|amod|END_ENTITY	The role of cAMP in ethanol-regulated beta-endorphin release from hypothalamic neurons .
11372371	0	cAMP	84,88	beta_2-adrenoceptor	15,34	cAMP	beta 2-adrenoceptor	CHEBI:17489	154	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of beta_2-adrenoceptor on peripheral lymphocyte and the level of plasma cAMP in patients with pregnancy induced hypertension -RSB- .
20965237	0	cAMP	0,4	bone_sialoprotein	45,62	cAMP	bone sialoprotein	CHEBI:17489	3381	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|compound|END_ENTITY	cAMP and fibroblast_growth_factor_2 regulate bone_sialoprotein gene expression in human prostate_cancer cells .
2156832	0	cAMP	65,69	cAMP-phosphodiesterase	37,59	cAMP	cAMP-phosphodiesterase	CHEBI:17489	854542(Tax:4932)	Chemical	Gene	analogues|compound|START_ENTITY END_ENTITY|nmod|analogues	Characterization of the yeast low Km cAMP-phosphodiesterase with cAMP analogues .
7876207	0	cAMP	31,35	cAR1	46,50	cAMP	cAR1	CHEBI:17489	9970	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Occupancy of the Dictyostelium cAMP receptor , cAR1 , induces a reduction in affinity which depends upon COOH-terminal serine residues .
8120068	0	cAMP	118,122	cAR1	133,137	cAMP	cAR1	CHEBI:17489	9970	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Localization of ligand-induced phosphorylation sites to serine clusters in the C-terminal domain of the Dictyostelium cAMP receptor , cAR1 .
8288619	0	cAMP	48,52	cAR1	63,67	cAMP	cAR1	CHEBI:17489	9970	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Mutation of the third intracellular loop of the cAMP receptor , cAR1 , of Dictyostelium yields mutants impaired in multiple signaling pathways .
8999903	0	cAMP	26,30	cAR1	57,61	cAMP	cAR1	CHEBI:17489	9970	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Random mutagenesis of the cAMP chemoattractant receptor , cAR1 , of Dictyostelium .
8999904	0	cAMP	26,30	cAR1	57,61	cAMP	cAR1	CHEBI:17489	9970	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Random mutagenesis of the cAMP chemoattractant receptor , cAR1 , of Dictyostelium .
10620499	0	cAMP	146,150	calcitonin_gene-related_peptide	97,128	cAMP	calcitonin gene-related peptide	CHEBI:17489	796	Chemical	Gene	factor|compound|START_ENTITY promoter|nmod|factor promoter|amod|END_ENTITY	Distinct signalling pathways mediate the cAMP response element -LRB- CRE -RRB- - dependent activation of the calcitonin_gene-related_peptide gene promoter by cAMP and nerve growth factor .
10620499	0	cAMP	41,45	calcitonin_gene-related_peptide	97,128	cAMP	calcitonin gene-related peptide	CHEBI:17489	796	Chemical	Gene	element|compound|START_ENTITY mediate|dobj|element pathways|dep|mediate pathways|dep|activation activation|nmod|promoter promoter|amod|END_ENTITY	Distinct signalling pathways mediate the cAMP response element -LRB- CRE -RRB- - dependent activation of the calcitonin_gene-related_peptide gene promoter by cAMP and nerve growth factor .
11744163	0	cAMP	14,18	calcitonin_gene-related_peptide	95,126	cAMP	calcitonin gene-related peptide	CHEBI:17489	796	Chemical	Gene	Production|nmod|START_ENTITY Production|dep|comparison comparison|nmod|END_ENTITY	Production of cAMP by adrenomedullin in human oligodendroglial cell line KG1C : comparison with calcitonin_gene-related_peptide and amylin .
7667288	0	cAMP	22,26	calcitonin_gene-related_peptide	50,81	cAMP	calcitonin gene-related peptide	CHEBI:17489	12310(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|cells cells|nmod|END_ENTITY	Specific induction of cAMP in Langerhans cells by calcitonin_gene-related_peptide : relevance to functional effects .
9838106	0	cAMP	0,4	calpastatin	34,45	cAMP	calpastatin	CHEBI:17489	281039(Tax:9913)	Chemical	Gene	responsiveness|compound|START_ENTITY responsiveness|nmod|promoter promoter|compound|END_ENTITY	cAMP responsiveness of the bovine calpastatin gene promoter .
1848176	0	cAMP	95,99	catalase_T	69,79	cAMP	catalase T	CHEBI:17489	852979(Tax:4932)	Chemical	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Negative regulation of transcription of the Saccharomyces_cerevisiae catalase_T -LRB- CTT1 -RRB- gene by cAMP is mediated by a positive control element .
2477692	0	cAMP	86,90	chorionic_gonadotropin_beta-subunit	42,77	cAMP	chorionic gonadotropin beta-subunit	CHEBI:17489	1082	Chemical	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	The transcriptional response of the human chorionic_gonadotropin_beta-subunit gene to cAMP is cycloheximide sensitive and is mediated by cis-acting sequences different from that found in the alpha-subunit gene .
10815617	0	cAMP	113,117	cyclooxygenase-2	17,33	cAMP	cyclooxygenase-2	CHEBI:17489	5743	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|induction induction|nmod|cells cells|amod|END_ENTITY	The induction of cyclooxygenase-2 in IL-1beta-treated endothelial cells is inhibited by prostaglandin_E2 through cAMP .
2154220	0	cAMP	19,23	cytochrome_P450	72,87	cAMP	cytochrome P450	CHEBI:17489	4051	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	A possible role of cAMP dependent phosphorylation of hepatic microsomal cytochrome_P450 : a mechanism to increase lipid peroxidation in response to hormone .
8292490	0	cAMP	11,15	dopamine_beta-hydroxylase	49,74	cAMP	dopamine beta-hydroxylase	CHEBI:17489	280758(Tax:9913)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effects of cAMP , glucocorticoids , and calcium on dopamine_beta-hydroxylase gene expression in bovine chromaffin cells .
12040051	0	cAMP	83,87	dunce	125,130	cAMP	dunce	CHEBI:17489	31309(Tax:7227)	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|nmod|END_ENTITY	Regional calcium regulation within cultured Drosophila neurons : effects of altered cAMP metabolism by the learning mutations dunce and rutabaga .
2546153	0	cAMP	73,77	dunce	67,72	cAMP	dunce	CHEBI:17489	31309(Tax:7227)	Chemical	Gene	phosphodiesterase|compound|START_ENTITY phosphodiesterase|compound|END_ENTITY	Molecular cloning of rat homologues of the Drosophila_melanogaster dunce cAMP phosphodiesterase : evidence for a family of genes .
3025834	0	cAMP	136,140	dunce	99,104	cAMP	dunce	CHEBI:17489	31309(Tax:7227)	Chemical	Gene	phosphodiesterase|compound|START_ENTITY gene|nmod|phosphodiesterase gene|appos|gene gene|amod|END_ENTITY	Molecular analysis of cDNA clones and the corresponding genomic coding sequences of the Drosophila dunce + gene , the structural gene for cAMP phosphodiesterase .
3034702	0	cAMP	93,97	dunce	33,38	cAMP	dunce	CHEBI:17489	31309(Tax:7227)	Chemical	Gene	role|nmod|START_ENTITY evidence|nmod|role provide|dobj|evidence provide|nsubj|mutants mutants|amod|END_ENTITY	Two Drosophila learning mutants , dunce and rutabaga , provide evidence of a maternal role for cAMP on embryogenesis .
8295075	0	cAMP	49,53	dunce	96,101	cAMP	dunce	CHEBI:17489	31309(Tax:7227)	Chemical	Gene	currents|nmod|START_ENTITY modulation|nmod|currents modulation|dep|mutants mutants|compound|END_ENTITY	Differential modulation of potassium currents by cAMP and its long-term and short-term effects : dunce and rutabaga mutants of Drosophila .
9454849	0	cAMP	115,119	dunce	47,52	cAMP	dunce	CHEBI:17489	31309(Tax:7227)	Chemical	Gene	downregulated|nmod|START_ENTITY component|acl|downregulated lacks|dobj|component lacks|nsubj|END_ENTITY	Outward currents in Drosophila larval neurons : dunce lacks a maintained outward current component downregulated by cAMP .
8531093	0	cAMP	66,70	endothelin-1	50,62	cAMP	endothelin-1	CHEBI:17489	1906	Chemical	Gene	accumulation|compound|START_ENTITY END_ENTITY|nmod|accumulation	Prostaglandins mediate the stimulatory effects of endothelin-1 on cAMP accumulation and inositol-1 ,4,5 - trisphosphate production and contraction in cat iris sphincter .
23447132	0	cAMP	66,70	epac	45,49	cAMP	epac	CHEBI:17489	10411	Chemical	Gene	mediator|compound|START_ENTITY protein|dep|mediator protein|acl|activated activated|nmod|cAMP cAMP|dep|END_ENTITY	Exchange protein directly activated by cAMP -LRB- epac -RRB- : a multidomain cAMP mediator in the regulation of diverse biological functions .
1323727	0	cAMP	109,113	erythropoietin	34,48	cAMP	erythropoietin	CHEBI:17489	24335(Tax:10116)	Chemical	Gene	mediation|nmod|START_ENTITY evidence|nmod|mediation changes|dep|evidence changes|nmod|mRNA mRNA|compound|END_ENTITY	Rapid oxygen-dependent changes in erythropoietin mRNA in perfused rat kidneys : evidence against mediation by cAMP .
2435340	0	cAMP	15,19	erythropoietin	23,37	cAMP	erythropoietin	CHEBI:17489	2056	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Stimulation by cAMP of erythropoietin secretion by an established human renal_carcinoma cell line .
3036549	0	cAMP	12,16	erythropoietin	94,108	cAMP	erythropoietin	CHEBI:17489	100008786(Tax:9986)	Chemical	Gene	role|nmod|START_ENTITY erythroblasts|nsubj|role erythroblasts|nmod|END_ENTITY	The role of cAMP and calcium in the stimulation of proliferation of immature erythroblasts by erythropoietin .
19264843	0	cAMP	0,4	estrogen-related_receptor_alpha	14,45	cAMP	estrogen-related receptor alpha	CHEBI:17489	2101	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|xcomp|END_ENTITY	cAMP enhances estrogen-related_receptor_alpha -LRB- ERRalpha -RRB- transcriptional activity at the SP-A promoter by increasing its interaction with protein kinase A and steroid_receptor_coactivator_2 -LRB- SRC-2 -RRB- .
20360387	0	cAMP	107,111	estrogen_receptor_alpha	80,103	cAMP	estrogen receptor alpha	CHEBI:17489	2099	Chemical	Gene	mediates|nmod|START_ENTITY mediates|dobj|activation activation|nmod|END_ENTITY	CARM1 mediates the ligand-independent and tamoxifen-resistant activation of the estrogen_receptor_alpha by cAMP .
2847254	1	cAMP	309,313	gastrin	331,338	cAMP	gastrin	CHEBI:17489	25320(Tax:10116)	Chemical	Gene	monophosphate|appos|START_ENTITY potentiated|nsubj|monophosphate potentiated|dobj|response response|compound|END_ENTITY	We and others have recently reported an involvement of calcium -LRB- Ca2 + -RRB- - mediated intracellular pathways in the release of antral gastrin in response to bombesin -LRB- BBS -RRB- , while cyclic_adenosine_3 ' 5 ' - monophosphate -LRB- cAMP -RRB- potentiated the gastrin response to BBS .
7573458	0	cAMP	0,4	gastrin	15,22	cAMP	gastrin	CHEBI:17489	2520	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	cAMP regulates gastrin gene expression .
2841160	0	cAMP	47,51	glucagon-like_peptide_1	20,43	cAMP	glucagon-like peptide 1	CHEBI:17489	24952(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of truncated glucagon-like_peptide_1 on cAMP in rat gastric glands and HGT-1 human gastric_cancer cells .
9845337	0	cAMP	45,49	haptoglobin	14,25	cAMP	haptoglobin	CHEBI:17489	24464(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Activation of haptoglobin gene expression by cAMP involves CCAAT/enhancer-binding _ protein isoforms in intestinal epithelial cells .
9249506	0	cAMP	0,4	heme_oxygenase-1	13,29	cAMP	heme oxygenase-1	CHEBI:17489	24451(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	cAMP induces heme_oxygenase-1 gene expression and carbon_monoxide production in vascular smooth muscle .
18675312	0	cAMP	61,65	hepatic_lipase	19,33	cAMP	hepatic lipase	CHEBI:17489	3990	Chemical	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|nmod|expression expression|amod|END_ENTITY	Down-regulation of hepatic_lipase expression by elevation of cAMP in human hepatoma but not adrenocortical cells .
8836156	0	cAMP	58,62	hormone-sensitive_lipase	14,38	cAMP	hormone-sensitive lipase	CHEBI:17489	16890(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Inhibition of hormone-sensitive_lipase gene expression by cAMP and phorbol_esters in 3T3-F442A and BFC-1 adipocytes .
15528042	0	cAMP	13,17	iNOS	21,25	cAMP	iNOS	CHEBI:17489	4843	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Dual role of cAMP in iNOS expression in glial cells and macrophages is mediated by differential regulation of p38-MAPK/ATF -2 activation and iNOS stability .
26334033	0	cAMP	99,103	iNOS	109,113	cAMP	iNOS	CHEBI:17489	18126(Tax:10090)	Chemical	Gene	myocardial_depression|nmod|START_ENTITY controls|dobj|myocardial_depression controls|dep|END_ENTITY	Phosphoinositide 3-kinase gamma controls inflammation-induced myocardial_depression via sequential cAMP - and iNOS - signaling .
9034831	2	cAMP	865,869	iNOS	925,929	cAMP	iNOS	CHEBI:17489	24599(Tax:10116)	Chemical	Gene	levels|appos|START_ENTITY increase|dobj|levels known|xcomp|increase prostaglandin_E2|acl:relcl|known downregulates|nsubj|prostaglandin_E2 downregulates|dobj|expression expression|compound|END_ENTITY	In this study we show that exogenous prostaglandin_E2 -LRB- PGE2 -RRB- , which is known to increase cyclic_adenosine_monophosphate -LRB- cAMP -RRB- levels in microglial cells , downregulates LPS-induced iNOS expression in a dose-dependent manner .
9588181	0	cAMP	120,124	iNOS	33,37	cAMP	iNOS	CHEBI:17489	4843	Chemical	Gene	increase|nmod|START_ENTITY triggered|nmod|increase monocytes|acl|triggered expression|nmod|monocytes expression|dep|END_ENTITY	Inducible nitric_oxide synthase -LRB- iNOS -RRB- expression in human monocytes triggered by beta-endorphin through an increase in cAMP .
11469895	0	cAMP	0,4	inducible_nitric_oxide_synthase	14,45	cAMP	inducible nitric oxide synthase	CHEBI:17489	24599(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	cAMP inhibits inducible_nitric_oxide_synthase expression and NF-kappaB-binding activity in cultured rat hepatocytes .
8594915	0	cAMP	0,4	inducible_nitric_oxide_synthase	14,45	cAMP	inducible nitric oxide synthase	CHEBI:17489	24599(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|stability stability|amod|END_ENTITY	cAMP enhances inducible_nitric_oxide_synthase mRNA stability in cardiac myocytes .
1310538	0	cAMP	77,81	insulin	26,33	cAMP	insulin	CHEBI:17489	3630	Chemical	Gene	elements|compound|START_ENTITY depends|nmod|elements activity|acl:relcl|depends activity|compound|END_ENTITY	c-Jun represses the human insulin promoter activity that depends on multiple cAMP response elements .
20498366	0	cAMP	0,4	insulin	28,35	cAMP	insulin	CHEBI:17489	3630	Chemical	Gene	mediators|compound|START_ENTITY mediators|nmod|END_ENTITY	cAMP mediators of pulsatile insulin secretion from glucose-stimulated single beta-cells .
23592482	0	cAMP	52,56	insulin	96,103	cAMP	insulin	CHEBI:17489	3630	Chemical	Gene	generation|compound|START_ENTITY promotes|nsubj|generation promotes|dobj|secretion secretion|compound|END_ENTITY	Glucagon-like_peptide-1_receptor-mediated endosomal cAMP generation promotes glucose-stimulated insulin secretion in pancreatic b-cells .
2476830	5	cAMP	729,733	insulin	771,778	cAMP	insulin	CHEBI:17489	3630	Chemical	Gene	levels|compound|START_ENTITY changes|nmod|levels found|nsubjpass|changes found|nmod|addition addition|nmod|END_ENTITY	No significant changes in cAMP levels were found on the addition of insulin into the culture medium .
7983773	0	cAMP	48,52	insulin	21,28	cAMP	insulin	CHEBI:17489	3630	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	-LSB- Regulation of human insulin gene expression by cAMP -RSB- .
8032004	0	cAMP	159,163	insulin	72,79	cAMP	insulin	CHEBI:17489	396145(Tax:9031)	Chemical	Gene	generation|nmod|START_ENTITY receptor|acl|generation amyloid|nmod|receptor amyloid|dobj|secretion secretion|compound|END_ENTITY	Calcitonin gene-related peptide and islet amyloid polypeptide stimulate insulin secretion in RINm5F cells through a common receptor coupled to a generation of cAMP .
9726231	0	cAMP	8,12	insulin	32,39	cAMP	insulin	CHEBI:17489	3630	Chemical	Gene	START_ENTITY|nmod|upregulation upregulation|nmod|END_ENTITY	Role of cAMP in upregulation of insulin secretion during the adaptation of islets of Langerhans to pregnancy .
2419331	0	cAMP	15,19	insulin_receptor	110,126	cAMP	insulin receptor	CHEBI:17489	3643	Chemical	Gene	content|compound|START_ENTITY Increasing|dobj|content alters|csubj|Increasing alters|dobj|state state|nmod|END_ENTITY	Increasing the cAMP content of IM-9 cells alters the phosphorylation state and protein kinase activity of the insulin_receptor .
3036692	0	cAMP	10,14	insulin_receptor	49,65	cAMP	insulin receptor	CHEBI:17489	3643	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of cAMP on down-regulation of erythrocyte insulin_receptor .
3539674	0	cAMP	48,52	insulin_receptor	28,44	cAMP	insulin receptor	CHEBI:17489	3643	Chemical	Gene	kinase|compound|START_ENTITY END_ENTITY|nmod|kinase	Phosphorylation of purified insulin_receptor by cAMP kinase .
7592673	0	cAMP	44,48	interleukin-5	18,31	cAMP	interleukin-5	CHEBI:17489	16191(Tax:10090)	Chemical	Gene	promoter|nmod|START_ENTITY promoter|amod|END_ENTITY	Activation of the interleukin-5 promoter by cAMP in murine EL-4 cells requires the GATA-3 and CLE0 elements .
1338333	0	cAMP	9,13	interleukin_1	69,82	cAMP	interleukin 1	CHEBI:17489	111343(Tax:10090)	Chemical	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	Elevated cAMP is required for stimulation of eicosanoid synthesis by interleukin_1 and bradykinin in BALB/c 3T3 fibroblasts .
2484435	0	cAMP	145,149	interleukin_1	80,93	cAMP	interleukin 1	CHEBI:17489	3552	Chemical	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	Synergistic induction of interleukin 2 receptor -LRB- TAC -RRB- expression on YT cells by interleukin_1 or tumor_necrosis_factor_alpha in combination with cAMP inducing agents .
10462716	0	cAMP	65,69	lysyl_oxidase	16,29	cAMP	lysyl oxidase	CHEBI:17489	4015	Chemical	Gene	cells|nmod|START_ENTITY cells|amod|END_ENTITY	Upregulation of lysyl_oxidase in vascular smooth muscle cells by cAMP : role for adenosine receptor activation .
10926834	0	cAMP	0,4	macrophage_colony-stimulating_factor	41,77	cAMP	macrophage colony-stimulating factor	CHEBI:17489	1435	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|amod|END_ENTITY	cAMP attenuates interleukin-1-stimulated macrophage_colony-stimulating_factor -LRB- M-CSF -RRB- expression .
9852118	0	cAMP	67,71	mammalian_target_of_rapamycin	15,44	cAMP	mammalian target of rapamycin	CHEBI:17489	2475	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Attenuation of mammalian_target_of_rapamycin activity by increased cAMP in 3T3-L1 adipocytes .
23000456	0	cAMP	80,84	melanocortin_1_receptor	39,62	cAMP	melanocortin 1 receptor	CHEBI:17489	4157	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Functional status and relationships of melanocortin_1_receptor signaling to the cAMP and extracellular signal-regulated protein kinases 1 and 2 pathways in human melanoma cells .
7518008	0	cAMP	35,39	myelin_basic_protein	54,74	cAMP	myelin basic protein	CHEBI:17489	4155	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Involvement of protein kinase C in cAMP regulation of myelin_basic_protein gene expression .
12528891	0	cAMP	0,4	p38_MAPK	95,103	cAMP	p38 MAPK	CHEBI:17489	26416(Tax:10090)	Chemical	Gene	elevators|compound|START_ENTITY inhibit|nsubj|elevators inhibit|advcl|interfering interfering|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	cAMP elevators inhibit LPS-induced IL-12_p40 expression by interfering with phosphorylation of p38_MAPK in murine peritoneal macrophages .
20070884	0	cAMP	71,75	p38_MAPK	48,56	cAMP	p38 MAPK	CHEBI:17489	26416(Tax:10090)	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Selective unresponsiveness to the inhibition of p38_MAPK activation by cAMP helps L929 fibroblastoma cells escape TNF-alpha-induced cell death .
1652259	0	cAMP	43,47	parathyroid_hormone	16,35	cAMP	parathyroid hormone	CHEBI:17489	5741	Chemical	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	Effect of human parathyroid_hormone on the cAMP production and the endocrine functions of trophoblast cells from first trimester placenta .
206800	0	cAMP	37,41	parathyroid_hormone	54,73	cAMP	parathyroid hormone	CHEBI:17489	24694(Tax:10116)	Chemical	Gene	response|compound|START_ENTITY potentiate|dobj|response potentiate|advcl|END_ENTITY	Thiazide diuretics do not potentiate cAMP response to parathyroid_hormone .
2178252	0	cAMP	16,20	parathyroid_hormone	89,108	cAMP	parathyroid hormone	CHEBI:17489	5741	Chemical	Gene	accumulation|compound|START_ENTITY Dissociation|nmod|accumulation uptake|nsubj|Dissociation uptake|nmod|cells cells|nmod|END_ENTITY	Dissociation of cAMP accumulation and phosphate uptake in opossum kidney -LRB- OK -RRB- cells with parathyroid_hormone -LRB- PTH -RRB- and parathyroid_hormone related protein -LRB- PTHrP -RRB- .
2463067	0	cAMP	114,118	parathyroid_hormone	81,100	cAMP	parathyroid hormone	CHEBI:17489	396436(Tax:9031)	Chemical	Gene	role|nmod|START_ENTITY Induction|dep|role Induction|nmod|activity activity|nmod|osteoblasts osteoblasts|nmod|END_ENTITY	Induction of ornithine_decarboxylase activity in isolated chicken osteoblasts by parathyroid_hormone : the role of cAMP and calcium .
2536232	0	cAMP	38,42	parathyroid_hormone	55,74	cAMP	parathyroid hormone	CHEBI:17489	24694(Tax:10116)	Chemical	Gene	response|compound|START_ENTITY Effects|nmod|response Effects|nmod|END_ENTITY	Effects of lectins and tunicamycin on cAMP response to parathyroid_hormone .
2835136	0	cAMP	55,59	parathyroid_hormone	10,29	cAMP	parathyroid hormone	CHEBI:17489	24694(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY Effect|nmod|levels Effect|nmod|END_ENTITY	Effect of parathyroid_hormone and antagonist on aortic cAMP levels .
2837557	0	cAMP	88,92	parathyroid_hormone	105,124	cAMP	parathyroid hormone	CHEBI:17489	24694(Tax:10116)	Chemical	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	Response of cultured bone cells to a capacitively coupled electric field : inhibition of cAMP response to parathyroid_hormone .
3003125	0	cAMP	136,140	parathyroid_hormone	91,110	cAMP	parathyroid hormone	CHEBI:17489	5741	Chemical	Gene	response|compound|START_ENTITY responses|nmod|response responses|nmod|END_ENTITY	Electrophysiological differences between bone cell clones : membrane potential responses to parathyroid_hormone and correlation with the cAMP response .
6091653	0	cAMP	34,38	parathyroid_hormone	11,30	cAMP	parathyroid hormone	CHEBI:17489	19226(Tax:10090)	Chemical	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	Effects of parathyroid_hormone on cAMP production and alkaline phosphatase activity in osteoblastic clone MC3T3-E1 cells .
6095675	0	cAMP	0,4	parathyroid_hormone	56,75	cAMP	parathyroid hormone	CHEBI:17489	280903(Tax:9913)	Chemical	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	cAMP response of vascular smooth muscle cells to bovine parathyroid_hormone .
6259655	0	cAMP	46,50	parathyroid_hormone	79,98	cAMP	parathyroid hormone	CHEBI:17489	5741	Chemical	Gene	adenosine_monophosphate|appos|START_ENTITY adenosine_monophosphate|dep|index index|nmod|action action|nmod|END_ENTITY	Urinary cyclic_3 ' ,5 ' - adenosine_monophosphate -LRB- cAMP -RRB- : an index of the action of parathyroid_hormone on the kidney .
6271524	0	cAMP	67,71	parathyroid_hormone	20,39	cAMP	parathyroid hormone	CHEBI:17489	19226(Tax:10090)	Chemical	Gene	responses|compound|START_ENTITY responses|nmod|effects effects|nmod|END_ENTITY	In vitro effects of parathyroid_hormone on kidney cortical slices : cAMP responses and concomitant inhibition of the Na + gradient-dependent uptake of phosphate by brush border membrane vesicles isolated from the renal slices .
6291951	0	cAMP	64,68	parathyroid_hormone	10,29	cAMP	parathyroid hormone	CHEBI:17489	24694(Tax:10116)	Chemical	Gene	content|compound|START_ENTITY Effect|nmod|content Effect|nmod|END_ENTITY	Effect of parathyroid_hormone , calcitonin and growth_hormone on cAMP content of growth cartilage in experimental uraemia .
6294581	0	cAMP	33,37	parathyroid_hormone	10,29	cAMP	parathyroid hormone	CHEBI:17489	5741	Chemical	Gene	formation|compound|START_ENTITY Effect|nmod|formation Effect|nmod|END_ENTITY	Effect of parathyroid_hormone on cAMP and 1,25-dihydroxyvitamin _ D formation and renal handling of phosphate in vitamin_D-dependent_rickets .
8631918	0	cAMP	156,160	parathyroid_hormone	15,34	cAMP	parathyroid hormone	CHEBI:17489	5741	Chemical	Gene	transduction|compound|START_ENTITY induced|nmod|transduction response|acl|induced response|nsubj|Stimulation Stimulation|nmod|END_ENTITY	Stimulation by parathyroid_hormone of interleukin-6 and leukemia_inhibitory_factor expression in osteoblasts is an immediate-early gene response induced by cAMP signal transduction .
8969199	0	cAMP	144,148	parathyroid_hormone	61,80	cAMP	parathyroid hormone	CHEBI:17489	100462909	Chemical	Gene	critical|xcomp|START_ENTITY signal|parataxis|critical signal|nsubj|region region|nmod|loop loop|nmod|END_ENTITY	The N-terminal region of the third intracellular loop of the parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide receptor is critical for coupling to cAMP and inositol_phosphate / Ca2 + signal transduction pathways .
9258752	0	cAMP	97,101	parathyroid_hormone	39,58	cAMP	parathyroid hormone	CHEBI:17489	5741	Chemical	Gene	production|compound|START_ENTITY modulates|dobj|production modulates|nsubj|Down-regulation Down-regulation|nmod|differentially differentially|amod|protein_kinase_C protein_kinase_C|nmod|END_ENTITY	Down-regulation of protein_kinase_C by parathyroid_hormone and mezerein differentially modulates cAMP production and phosphate transport in opossum kidney cells .
15187419	0	cAMP	25,29	phosphodiesterase_3	30,49	cAMP	phosphodiesterase 3	CHEBI:17489	498900(Tax:10116)	Chemical	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Orthovanadate stimulates cAMP phosphodiesterase_3 activity in isolated rat hepatocytes through mitogen-activated protein kinase activation dependent on cAMP-dependent protein kinase .
12169692	0	cAMP	69,73	phosphodiesterase_3B	18,38	cAMP	phosphodiesterase 3B	CHEBI:17489	29516(Tax:10116)	Chemical	Gene	action|nmod|START_ENTITY END_ENTITY|nmod|action	Important role of phosphodiesterase_3B for the stimulatory action of cAMP on pancreatic beta-cell exocytosis and release of insulin .
10793626	0	cAMP	68,72	phospholipase_A2	94,110	cAMP	phospholipase A2	CHEBI:17489	151056	Chemical	Gene	downstream|compound|START_ENTITY downstream|nmod|END_ENTITY	Stimulation of Ca -LRB- 2 + -RRB- - dependent exocytosis of the sperm acrosome by cAMP acting downstream of phospholipase_A2 .
11500033	0	cAMP	44,48	phospholipase_C_delta3	18,40	cAMP	phospholipase C delta3	CHEBI:17489	113026	Chemical	Gene	Downregulation|nmod|START_ENTITY Downregulation|nmod|END_ENTITY	Downregulation of phospholipase_C_delta3 by cAMP and calcium .
10327185	0	cAMP	53,57	phospholipase_D1	24,40	cAMP	phospholipase D1	CHEBI:17489	25096(Tax:10116)	Chemical	Gene	mRNA|nmod|START_ENTITY mRNA|amod|END_ENTITY	Increased expression of phospholipase_D1 mRNA during cAMP - or NGF-induced differentiation in PC12 cells .
2850173	0	cAMP	92,96	proenkephalin	78,91	cAMP	proenkephalin	CHEBI:17489	5179	Chemical	Gene	transcription|compound|START_ENTITY transcription|compound|END_ENTITY	Proteins bound at adjacent DNA elements act synergistically to regulate human proenkephalin cAMP inducible transcription .
12409212	0	cAMP	78,82	prolactin	115,124	cAMP	prolactin	CHEBI:17489	100303694(Tax:9103)	Chemical	Gene	messenger|compound|START_ENTITY messenger|nmod|expression expression|compound|END_ENTITY	Influence of VIP on prolactinemia in turkey anterior pituitary cells : role of cAMP second messenger in VIP-induced prolactin gene expression .
1655738	0	cAMP	57,61	prolactin	39,48	cAMP	prolactin	CHEBI:17489	5617	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Transcriptional induction of the human prolactin gene by cAMP requires two cis-acting elements and at least the pituitary-specific factor Pit-1 .
16630538	0	cAMP	72,76	prolactin	13,22	cAMP	prolactin	CHEBI:17489	5617	Chemical	Gene	ligands|compound|START_ENTITY Induction|nmod|ligands Induction|nmod|expression expression|compound|END_ENTITY	Induction of prolactin expression and release in human preadipocytes by cAMP activating ligands .
2887367	0	cAMP	131,135	prolactin	79,88	cAMP	prolactin	CHEBI:17489	5617	Chemical	Gene	boddaerti|appos|START_ENTITY effect|dep|boddaerti effect|dep|T3 T3|amod|END_ENTITY	Environmental effect on plasma thyroxine _ -LRB- T4 -RRB- , 3,5,3 ' - triido-L-thyronine -LRB- T3 -RRB- , prolactin and cyclic_adenosine_3 ' ,5 ' - monophosphate -LRB- cAMP -RRB- content in the mudskippers Periophthalmus chrysospilos and Boleophthalmus boddaerti .
9058009	0	cAMP	80,84	prolactin	44,53	cAMP	prolactin	CHEBI:17489	24683(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY involving|dobj|production involving|nsubj|release release|nmod|END_ENTITY	Progesterone stimulates in vitro release of prolactin and thyrotropin involving cAMP production in rat pituitary .
9220025	0	cAMP	91,95	prolactin	21,30	cAMP	prolactin	CHEBI:17489	24683(Tax:10116)	Chemical	Gene	mechanism|amod|START_ENTITY decreases|nmod|mechanism decreases|dobj|expression expression|compound|END_ENTITY	Lovastatin decreases prolactin and growth_hormone gene expression in GH4C1 cells through a cAMP dependent mechanism .
18502451	0	cAMP	0,4	protein_kinase_A	54,70	cAMP	protein kinase A	CHEBI:17489	25636(Tax:10116)	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	cAMP promotes neurite outgrowth and extension through protein_kinase_A but independently of Erk activation in cultured rat motoneurons .
8619804	0	cAMP	0,4	protein_kinase_A	22,38	cAMP	protein kinase A	CHEBI:17489	34284(Tax:7227)	Chemical	Gene	START_ENTITY|appos|activator activator|nmod|END_ENTITY	cAMP , an activator of protein_kinase_A , suppresses the expression of sonic hedgehog .
1655570	0	cAMP	0,4	rNFIL-6	55,62	cAMP	rNFIL-6	CHEBI:17489	24253(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|xcomp|END_ENTITY	cAMP stimulates the C/EBP-related transcription factor rNFIL-6 to trans-locate to the nucleus and induce c-fos transcription .
7581952	0	cAMP	57,61	rPL-II	71,77	cAMP	rPL-II	CHEBI:17489	24283(Tax:10116)	Chemical	Gene	secretion|compound|START_ENTITY secretion|compound|END_ENTITY	Regulation of rat placental lactogen -LRB- rPL -RRB- - II secretion : cAMP inhibits rPL-II secretion in vitro .
9247737	0	cAMP	48,52	renin	20,25	cAMP	renin	CHEBI:17489	5972	Chemical	Gene	transcription|nmod|START_ENTITY transcription|nsubj|Regulation Regulation|nmod|gene gene|compound|END_ENTITY	Regulation of human renin gene transcription by cAMP .
7587654	0	cAMP	49,53	somatostatin	14,26	cAMP	somatostatin	CHEBI:17489	6750	Chemical	Gene	transcription|nmod|START_ENTITY transcription|nsubj|Regulation Regulation|nmod|gene gene|compound|END_ENTITY	Regulation of somatostatin gene transcription by cAMP .
8957233	0	cAMP	126,130	somatostatin	61,73	cAMP	somatostatin	CHEBI:17489	6750	Chemical	Gene	role|nmod|START_ENTITY modulation|dep|role modulation|nmod|release release|compound|END_ENTITY	Presynaptic modulation by VIP , secretin and isoproterenol of somatostatin release from enriched enteric synaptosomes : role of cAMP .
8394371	0	cAMP	60,64	syndecan-1	35,45	cAMP	syndecan-1	CHEBI:17489	20969(Tax:10090)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Post-transcriptional regulation of syndecan-1 expression by cAMP in peritoneal macrophages .
17090405	0	cAMP	27,31	thrombomodulin	45,59	cAMP	thrombomodulin	CHEBI:17489	83580(Tax:10116)	Chemical	Gene	mRNA|amod|START_ENTITY mRNA|compound|END_ENTITY	Elevation of intracellular cAMP up-regulated thrombomodulin mRNA in cultured vascular endothelial cells derived from spontaneous type-II diabetes_mellitus model rat .
7665981	0	cAMP	0,4	thrombomodulin	35,49	cAMP	thrombomodulin	CHEBI:17489	7056	Chemical	Gene	influence|compound|START_ENTITY influence|nmod|transcription transcription|nmod|END_ENTITY	cAMP influence on transcription of thrombomodulin is dependent on de novo synthesis of a protein intermediate : evidence for cohesive regulation of myogenic proteins in vascular smooth muscle .
2170261	0	cAMP	36,40	thyroperoxidase	70,85	cAMP	thyroperoxidase	CHEBI:17489	403521(Tax:9615)	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|END_ENTITY	Distinct transcriptional effects of cAMP on 2 thyroid specific genes : thyroperoxidase and thyroglobulin .
2560810	0	cAMP	62,66	thyroperoxidase	11,26	cAMP	thyroperoxidase	CHEBI:17489	403521(Tax:9615)	Chemical	Gene	transcription|nmod|START_ENTITY transcription|compound|END_ENTITY	Control of thyroperoxidase and thyroglobulin transcription by cAMP : evidence for distinct regulatory mechanisms .
7556171	0	cAMP	9,13	thyrotropin_receptor	40,60	cAMP	thyrotropin receptor	CHEBI:17489	7253	Chemical	Gene	accumulation|compound|START_ENTITY accumulation|nmod|END_ENTITY	Enhanced cAMP accumulation by the human thyrotropin_receptor variant with the Pro52Thr substitution in the extracellular domain .
11469886	0	cAMP	57,61	tumor_necrosis_factor_alpha	15,42	cAMP	tumor necrosis factor alpha	CHEBI:17489	7124	Chemical	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	Suppression of tumor_necrosis_factor_alpha production by cAMP in human monocytes : dissociation with mRNA level and independent of interleukin-10 .
8707852	0	cAMP	44,48	tyrosinase	14,24	cAMP	tyrosinase	CHEBI:17489	22173(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of tyrosinase gene expression by cAMP in B16 melanoma cells involves two CATGTG motifs surrounding the TATA box : implication of the microphthalmia gene product .
20583	0	cAMP	14,18	tyrosine_hydroxylase	22,42	cAMP	tyrosine hydroxylase	CHEBI:17489	7054	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|amod|END_ENTITY	Effects of db cAMP on tyrosine_hydroxylase activity of ganglia and nerve endings .
17427962	0	cAMP	125,129	vascular_endothelial_growth_factor	25,59	cAMP	vascular endothelial growth factor	CHEBI:17489	7422	Chemical	Gene	pathway|compound|START_ENTITY induces|nmod|pathway induces|dobj|secretion secretion|compound|END_ENTITY	Prostaglandin_E2 induces vascular_endothelial_growth_factor secretion in prostate_cancer cells through EP2 receptor-mediated cAMP pathway .
19571140	0	cAMP	71,75	vascular_endothelial_growth_factor	22,56	cAMP	vascular endothelial growth factor	CHEBI:17489	22339(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Induction of neuronal vascular_endothelial_growth_factor expression by cAMP in the dentate gyrus of the hippocampus is required for antidepressant-like behaviors .
8940064	0	cAMP	2,6	vascular_endothelial_growth_factor	114,148	cAMP	vascular endothelial growth factor	CHEBI:17489	7422	Chemical	Gene	element|compound|START_ENTITY involved|nsubjpass|element involved|nmod|regulation regulation|nmod|gene gene|dep|receptor receptor|compound|END_ENTITY	A cAMP response element and an Ets motif are involved in the transcriptional regulation of flt-1 tyrosine kinase -LRB- vascular_endothelial_growth_factor receptor 1 -RRB- gene .
9473343	0	cAMP	63,67	vascular_endothelial_growth_factor	14,48	cAMP	vascular endothelial growth factor	CHEBI:17489	83785(Tax:10116)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of vascular_endothelial_growth_factor expression by cAMP in rat aortic smooth muscle cells .
2548897	0	cAMP	102,106	vasopressin	11,22	cAMP	vasopressin	CHEBI:17489	551	Chemical	Gene	-RSB-|compound|START_ENTITY Effect|nmod|-RSB- Effect|nmod|END_ENTITY	-LSB- Effect of vasopressin on the osmotic permeability of the bladder wall in the frog and its content of cAMP , cGMP and inositol_triphosphate -RSB- .
6315490	0	cAMP	50,54	vasopressin	71,82	cAMP	vasopressin	CHEBI:17489	551	Chemical	Gene	accumulation|compound|START_ENTITY accumulation|nmod|END_ENTITY	Studies on the mechanism of inhibition of hepatic cAMP accumulation by vasopressin .
11313340	0	cAmp	0,4	arylalkylamine_N-acetyltransferase	19,53	cAmp	arylalkylamine N-acetyltransferase	CHEBI:17489	15	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	cAmp regulation of arylalkylamine_N-acetyltransferase -LRB- AANAT , EC 2.3.1.87 -RRB- : a new cell line -LRB- 1E7 -RRB- provides evidence of intracellular AANAT activation .
23348740	0	cGMP	34,38	67-kDa_laminin_receptor	0,23	cGMP	67-kDa laminin receptor	CHEBI:16356	16785(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|increases increases|amod|END_ENTITY	67-kDa_laminin_receptor increases cGMP to induce cancer-selective apoptosis .
2168680	0	cGMP	18,22	ANF	11,14	cGMP	ANF	CHEBI:16356	24602(Tax:10116)	Chemical	Gene	synthesis|compound|START_ENTITY Effects|nmod|synthesis Effects|nmod|END_ENTITY	Effects of ANF on cGMP synthesis in inner_medullary_collecting_duct subsegments of rats .
2545963	0	cGMP	37,41	ANF	73,76	cGMP	ANF	CHEBI:16356	4878	Chemical	Gene	involvement|appos|START_ENTITY involvement|nmod|factor factor|appos|END_ENTITY	-LSB- Possible involvement of cyclic_GMP -LRB- cGMP -RRB- in atrial natriuretic factor -LRB- ANF -RRB- induced natriuresis -RSB- .
2847533	0	cGMP	8,12	ANF	25,28	cGMP	ANF	CHEBI:16356	24602(Tax:10116)	Chemical	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	Blunted cGMP response to ANF in vascular smooth muscle cells of SHR .
3034249	0	cGMP	48,52	ANF	14,17	cGMP	ANF	CHEBI:16356	100008708(Tax:9986)	Chemical	Gene	response|compound|START_ENTITY analogs|nmod|response analogs|compound|END_ENTITY	Divergence of ANF analogs in smooth muscle cell cGMP response and aorta vasorelaxation : evidence for receptor subtypes .
9486247	0	cGMP	35,39	ANF	0,3	cGMP	ANF	CHEBI:16356	4878	Chemical	Gene	phosphodiesterase|compound|START_ENTITY phosphorylation|nmod|phosphodiesterase elicits|dobj|phosphorylation elicits|nsubj|END_ENTITY	ANF elicits phosphorylation of the cGMP phosphodiesterase in vascular smooth muscle cells .
11118555	0	cGMP	35,39	ATPase	0,6	cGMP	ATPase	CHEBI:16356	1769	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|nmod|transporter	ATPase activity and transport by a cGMP transporter in human erythrocyte ghosts and proteoliposome-reconstituted membrane extracts .
7827101	1	cGMP	126,130	AcP2	118,122	cGMP	AcP2	CHEBI:16356	24162(Tax:10116)	Chemical	Gene	mechanism|nmod|START_ENTITY mechanism|nmod|END_ENTITY	The activation mechanism of the isoenzyme AcP2 by cGMP .
7583539	0	cGMP	25,29	Angiotensin_II	0,14	cGMP	Angiotensin II	CHEBI:16356	24179(Tax:10116)	Chemical	Gene	content|compound|START_ENTITY increases|dobj|content increases|nsubj|END_ENTITY	Angiotensin_II increases cGMP content via endothelial angiotensin_II AT1 subtype receptors in the rat carotid artery .
12383147	8	cGMP	1018,1022	BNP	1007,1010	cGMP	BNP	CHEBI:16356	4879	Chemical	Gene	level|appos|START_ENTITY level|compound|END_ENTITY	Plasma BNP level , cGMP , and serum creatinine -LRB- Scr -RRB- were measured .
25423567	0	cGMP	17,21	COX-2	29,34	cGMP	COX-2	CHEBI:16356	5743	Chemical	Gene	START_ENTITY|dobj|Expression Expression|compound|END_ENTITY	Nitric_Oxide and cGMP Induce COX-2 Expression and PGE2 Production in Human Granulosa Cells Through CREB Signaling Pathway .
25423567	0	cGMP	17,21	CREB	99,103	cGMP	CREB	CHEBI:16356	1385	Chemical	Gene	START_ENTITY|nmod|Pathway Pathway|compound|END_ENTITY	Nitric_Oxide and cGMP Induce COX-2 Expression and PGE2 Production in Human Granulosa Cells Through CREB Signaling Pathway .
8386374	0	cGMP	13,17	DARPP-32	56,64	cGMP	DARPP-32	CHEBI:16356	360616(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Nitric_oxide / cGMP pathway stimulates phosphorylation of DARPP-32 , a dopamine - and cAMP-regulated phosphoprotein , in the substantia nigra .
11765058	0	cGMP	43,47	DHEAS	6,11	cGMP	DHEAS	CHEBI:16356	6822	Chemical	Gene	correlate|nmod|START_ENTITY correlate|nsubj|levels levels|compound|END_ENTITY	Serum DHEAS levels correlate with platelet cGMP in normal women .
14646243	0	cGMP	0,4	GTP_cyclohydrolase_I	14,34	cGMP	GTP cyclohydrolase I	CHEBI:16356	2643	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	cGMP inhibits GTP_cyclohydrolase_I activity and biosynthesis of tetrahydrobiopterin in human umbilical vein endothelial cells .
22806360	0	cGMP	46,50	Glucagon-like_peptide-2	0,23	cGMP	Glucagon-like peptide-2	CHEBI:16356	54269(Tax:10116)	Chemical	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	Glucagon-like_peptide-2 -LRB- GLP-2 -RRB- modulates the cGMP signalling pathway by regulating the expression of the soluble_guanylyl_cyclase receptor subunits in cultured rat astrocytes .
26216942	0	cGMP	43,47	Guanylate_Cyclase-C	23,42	cGMP	Guanylate Cyclase-C	CHEBI:16356	25711(Tax:10116)	Chemical	Gene	Pathway|compound|START_ENTITY Pathway|compound|END_ENTITY	MRP4 Modulation of the Guanylate_Cyclase-C / cGMP Pathway : Effects on Linaclotide-Induced Electrolyte Secretion and cGMP Efflux .
7511593	0	cGMP	25,29	Interleukin-4	0,13	cGMP	Interleukin-4	CHEBI:16356	3565	Chemical	Gene	production|compound|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Interleukin-4 stimulates cGMP production by IFN-gamma-activated human monocytes .
95804	1	cGMP	140,144	LIF	192,195	cGMP	LIF	CHEBI:16356	3976	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|nmod|END_ENTITY	Inhibitory effect of cGMP on the esterolytic activity of highly purified LIF .
15722341	0	cGMP	0,4	NHE3	40,44	cGMP	NHE3	CHEBI:16356	6550	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|appos|END_ENTITY	cGMP inhibition of Na + / H + antiporter 3 -LRB- NHE3 -RRB- requires PDZ domain adapter NHERF2 , a broad specificity protein kinase G-anchoring protein .
18394675	0	cGMP	140,144	PDE3A	176,181	cGMP	PDE3A	CHEBI:16356	5139	Chemical	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	A new nonhydrolyzable reactive cGMP analogue , -LRB- Rp -RRB- - guanosine-3 ' ,5 ' - cyclic-S - -LRB- 4-bromo-2 ,3 - dioxobutyl -RRB- monophosphorothioate , which targets the cGMP binding site of human platelet PDE3A .
15570464	0	cGMP	7,11	PDE5	12,16	cGMP	PDE5	CHEBI:16356	8654	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Use of cGMP PDE5 inhibitors in the treatment of neuropathy : a review of the patent literature .
9445376	0	cGMP	11,15	PDE5	90,94	cGMP	PDE5	CHEBI:16356	8654	Chemical	Gene	Binding|nmod|START_ENTITY Binding|appos|END_ENTITY	Binding of cGMP to both allosteric sites of cGMP-binding_cGMP-specific_phosphodiesterase -LRB- PDE5 -RRB- is required for its phosphorylation .
22328573	0	cGMP	39,43	Phosphodiesterase_9A	0,20	cGMP	Phosphodiesterase 9A	CHEBI:16356	5152	Chemical	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Phosphodiesterase_9A regulates central cGMP and modulates responses to cholinergic and monoaminergic perturbation in vivo .
10465516	0	cGMP	55,59	VIP	30,33	cGMP	VIP	CHEBI:16356	117064(Tax:10116)	Chemical	Gene	acts|nmod|START_ENTITY acts|nsubj|SNV SNV|appos|analog analog|compound|END_ENTITY	SNV , a lipophilic superactive VIP analog , acts through cGMP to promote neuronal survival .
3040005	0	cGMP	113,117	VIP	46,49	cGMP	VIP	CHEBI:16356	117064(Tax:10116)	Chemical	Gene	elevates|dobj|START_ENTITY elevates|nsubj|END_ENTITY	Transmembrane receptor cross-talk : concurrent VIP and alpha 1-adrenergic activation rapidly elevates pinealocyte cGMP greater than 100-fold .
7957315	0	cGMP	105,109	VIP	45,48	cGMP	VIP	CHEBI:16356	7432	Chemical	Gene	involved|nsubjpass|START_ENTITY IGR39|parataxis|involved IGR39|nsubj|Inhibition Inhibition|nmod|peptide peptide|appos|END_ENTITY	Inhibition of vasoactive intestinal peptide -LRB- VIP -RRB- binding on human melanoma cells IGR39 by nitric_oxide : cGMP is not involved .
11118339	0	cGMP	56,60	YC-1	0,4	cGMP	YC-1	CHEBI:16356	24421(Tax:10116)	Chemical	Gene	stimulates|dobj|START_ENTITY stimulates|nsubj|END_ENTITY	YC-1 , a benzyl_indazole derivative , stimulates vascular cGMP and inhibits neointima formation .
1318109	0	cGMP	45,49	atrial_natriuretic_factor	10,35	cGMP	atrial natriuretic factor	CHEBI:16356	24602(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY Effect|nmod|production Effect|nmod|END_ENTITY	Effect of atrial_natriuretic_factor on renal cGMP production in rats with adriamycin-induced nephrotic_syndrome .
1726323	0	cGMP	99,103	atrial_natriuretic_factor	52,77	cGMP	atrial natriuretic factor	CHEBI:16356	4878	Chemical	Gene	production|compound|START_ENTITY effects|nmod|production effects|nmod|END_ENTITY	Cyclic nucleotides in human macrophages : effects of atrial_natriuretic_factor and nitroprusside on cGMP and cAMP production .
9445376	0	cGMP	11,15	cGMP-binding_cGMP-specific_phosphodiesterase	44,88	cGMP	cGMP-binding cGMP-specific phosphodiesterase	CHEBI:16356	8654	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of cGMP to both allosteric sites of cGMP-binding_cGMP-specific_phosphodiesterase -LRB- PDE5 -RRB- is required for its phosphorylation .
11786513	0	cGMP	74,78	cGMP-dependent_protein_kinase_I	0,31	cGMP	cGMP-dependent protein kinase I	CHEBI:16356	19091(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY mediates|dobj|effect mediates|nsubj|END_ENTITY	cGMP-dependent_protein_kinase_I mediates the negative inotropic effect of cGMP in the murine myocardium .
24155296	0	cGMP	40,44	guanylate_cyclase	8,25	cGMP	guanylate cyclase	CHEBI:16356	60596(Tax:10090)	Chemical	Gene	generation|nmod|START_ENTITY generation|compound|END_ENTITY	Soluble guanylate_cyclase generation of cGMP regulates migration of MGE neurons .
9272623	0	cGMP	53,57	guanylin	78,86	cGMP	guanylin	CHEBI:16356	25656(Tax:10116)	Chemical	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Synthesis , solution structure , binding activity , and cGMP activation of human guanylin and its disulfide isomer .
9693113	0	cGMP	59,63	haem_oxygenase-1	34,50	cGMP	haem oxygenase-1	CHEBI:16356	24451(Tax:10116)	Chemical	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Transcriptional activation of the haem_oxygenase-1 gene by cGMP via a cAMP response element/activator protein-1 element in primary cultures of rat hepatocytes .
10910101	0	cGMP	51,55	heme_oxygenase-2	16,32	cGMP	heme oxygenase-2	CHEBI:16356	79239(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY END_ENTITY|nmod|levels	Localization of heme_oxygenase-2 and modulation of cGMP levels by carbon_monoxide and/or nitric_oxide in the retina .
12663242	0	cGMP	103,107	hsp32	53,58	cGMP	hsp32	CHEBI:16356	24451(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY induction|dep|role induction|nmod|END_ENTITY	Kupffer-cell specific induction of heme_oxygenase_1 -LRB- hsp32 -RRB- by the atrial_natriuretic_peptide -- role of cGMP .
18534985	0	cGMP	26,30	phosphodiesterase_5	55,74	cGMP	phosphodiesterase 5	CHEBI:16356	8654	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Solution structure of the cGMP binding GAF domain from phosphodiesterase_5 : insights into nucleotide specificity , dimerization , and cGMP-dependent conformational change .
15576651	0	cGMP	0,4	phosphodiesterase_5A	19,39	cGMP	phosphodiesterase 5A	CHEBI:16356	242202(Tax:10090)	Chemical	Gene	catabolism|compound|START_ENTITY catabolism|nmod|END_ENTITY	cGMP catabolism by phosphodiesterase_5A regulates cardiac adrenergic stimulation by NOS3-dependent mechanism .
16449359	0	cGMP	0,4	renin	16,21	cGMP	renin	CHEBI:16356	24715(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|compound|END_ENTITY	cGMP stimulates renin secretion in vivo by inhibiting phosphodiesterase-3 .
2409429	0	cGMP	110,114	renin	29,34	cGMP	renin	CHEBI:16356	24715(Tax:10116)	Chemical	Gene	alterations|nmod|START_ENTITY independence|nmod|alterations +|dep|independence +|dep|modulation modulation|nmod|release release|compound|END_ENTITY	Ca2 + - dependent modulation of renin release from isolated glomeruli : apparent independence from alterations in cGMP .
10235536	0	cGMP	105,109	vascular_endothelial_growth_factor	34,68	cGMP	vascular endothelial growth factor	CHEBI:16356	7422	Chemical	Gene	Suppression|nmod|START_ENTITY Suppression|nmod|expression expression|compound|END_ENTITY	Suppression of hypoxia-associated vascular_endothelial_growth_factor gene expression by nitric_oxide via cGMP .
11106920	0	cabergoline	47,58	growth_hormone	12,26	cabergoline	growth hormone	MESH:C047047	2688	Chemical	Gene	treatment|amod|START_ENTITY secretion|nmod|treatment secretion|amod|END_ENTITY	Recovery of growth_hormone secretion following cabergoline treatment of macroprolactinomas .
11579944	0	cabergoline	29,40	prolactin	62,71	cabergoline	prolactin	MESH:C047047	5617	Chemical	Gene	effects|nmod|START_ENTITY Comparison|nmod|effects Comparison|nmod|levels levels|compound|END_ENTITY	Comparison of the effects of cabergoline and bromocriptine on prolactin levels in hyperprolactinemic patients .
15070934	0	cabergoline	11,22	prolactin	94,103	cabergoline	prolactin	MESH:C047047	5617	Chemical	Gene	treatment|amod|START_ENTITY Outcome|nmod|treatment Outcome|dep|effects effects|nmod|treatment treatment|nmod|levels levels|compound|END_ENTITY	Outcome of cabergoline treatment in men with prolactinoma : effects of a 24-month treatment on prolactin levels , tumor mass , recovery of pituitary function , and semen analysis .
19754555	0	cabergoline	24,35	prolactin	57,66	cabergoline	prolactin	MESH:C047047	5617	Chemical	Gene	formulation|compound|START_ENTITY formulation|nmod|END_ENTITY	Effect of an injectable cabergoline formulation on serum prolactin -LRB- PRL -RRB- and milk secretion in early postpartum Beagle bitches .
20411477	0	cabergoline	39,50	prolactin	15,24	cabergoline	prolactin	MESH:C047047	24683(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Suppression of prolactin expression by cabergoline requires prolactin_regulatory_element-binding_protein -LRB- PREB -RRB- in GH3 cells .
2574083	0	cabergoline	19,30	prolactin	44,53	cabergoline	prolactin	MESH:C047047	5617	Chemical	Gene	treatment|compound|START_ENTITY treatment|nmod|END_ENTITY	Effect of subacute cabergoline treatment on prolactin , thyroid stimulating hormone and growth hormone response to simultaneous administration of thyrotrophin-releasing hormone and growth hormone-releasing hormone in hyperprolactinaemic women .
7901409	0	cabergoline	80,91	prolactin	23,32	cabergoline	prolactin	MESH:C047047	488241(Tax:9615)	Chemical	Gene	START_ENTITY|nsubj|action action|nmod|END_ENTITY	Luteotrophic action of prolactin in dogs and the effects of a dopamine agonist , cabergoline .
25042887	0	cabozantinib	16,28	RANKL	39,44	cabozantinib	RANKL	MESH:C558660	21943(Tax:10090)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|amod|END_ENTITY	Antitumor agent cabozantinib decreases RANKL expression in osteoblastic cells and inhibits osteoclastogenesis and PTHrP-stimulated bone resorption .
23705946	0	cabozantinib	33,45	RET	71,74	cabozantinib	RET	MESH:C558660	5979	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	In vitro and in vivo activity of cabozantinib -LRB- XL184 -RRB- , an inhibitor of RET , MET , and VEGFR2 , in a model of medullary_thyroid_cancer .
25242168	0	cabozantinib	29,41	c-MET	45,50	cabozantinib	c-MET	MESH:C558660	4233	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Potent antitumor activity of cabozantinib , a c-MET and VEGFR2 inhibitor , in a colorectal_cancer patient-derived tumor explant model .
25321478	0	cabozantinib	94,106	c-Met	14,19	cabozantinib	c-Met	MESH:C558660	17295(Tax:10090)	Chemical	Gene	Enrichment|nmod|START_ENTITY Enrichment|nmod|cells cells|amod|END_ENTITY	Enrichment of c-Met -LRB- + -RRB- tumorigenic stromal cells of giant_cell_tumor_of_bone and targeting by cabozantinib .
10051149	0	cacospongionolide_B	58,77	phospholipase_A2	115,131	cacospongionolide B	phospholipase A2	MESH:C098384	151056	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Modulation of acute and chronic inflammatory processes by cacospongionolide_B , a novel inhibitor of human synovial phospholipase_A2 .
23060935	0	cadmium	14,21	APP/PS1	38,45	cadmium	APP/PS1	MESH:D002104	11820;19164	Chemical	Gene	START_ENTITY|nmod|levels levels|nmod|END_ENTITY	The effect of cadmium on Ab levels in APP/PS1 transgenic_mice .
21919981	0	cadmium	72,79	AtABCC1	31,38	cadmium	AtABCC1	MESH:D002104	839920(Tax:3702)	Chemical	Gene	mediate|nmod|START_ENTITY mediate|nsubj|END_ENTITY	The phytochelatin transporters AtABCC1 and AtABCC2 mediate tolerance to cadmium and mercury .
25297078	0	cadmium	42,49	BTG1	85,89	cadmium	BTG1	MESH:D002104	105340066	Chemical	Gene	changes|amod|START_ENTITY changes|nmod|END_ENTITY	Molecular cloning , sequence analysis , and cadmium stress-rated expression changes of BTG1 in freshwater pearl mussel -LRB- Hyriopsis_schlegelii -RRB- .
16188096	0	cadmium	102,109	Bax	20,23	cadmium	Bax	MESH:D002104	12028(Tax:10090)	Chemical	Gene	-RSB-|compound|START_ENTITY exposed|nmod|-RSB- exposed|nsubj|expression expression|dep|END_ENTITY	-LSB- DNA damage , Bcl-2 , Bax expression and ultrastructure change in spermatogenic cell of mice exposed to cadmium -RSB- .
16188096	0	cadmium	102,109	Bcl-2	13,18	cadmium	Bcl-2	MESH:D002104	12043(Tax:10090)	Chemical	Gene	-RSB-|compound|START_ENTITY exposed|nmod|-RSB- exposed|nsubj|expression expression|dep|END_ENTITY	-LSB- DNA damage , Bcl-2 , Bax expression and ultrastructure change in spermatogenic cell of mice exposed to cadmium -RSB- .
3800302	0	cadmium	10,17	CCK	115,118	cadmium	CCK	MESH:D002104	25298(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of cadmium and bombesin on exocrine pancreatic secretions and plasma levels of gastrin and cholecystokinin -LRB- CCK -RRB- in rats .
14687664	0	cadmium	78,85	COX-2	16,21	cadmium	COX-2	MESH:D002104	19225(Tax:10090)	Chemical	Gene	regulates|nmod|START_ENTITY regulates|dobj|upregulation upregulation|compound|END_ENTITY	Redox regulates COX-2 upregulation and cell death in the neuronal response to cadmium .
22767315	0	cadmium	68,75	COX-2	48,53	cadmium	COX-2	MESH:D002104	26198(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Transcriptional and translational regulation of COX-2 expression by cadmium in C6 glioma cells .
10098900	0	cadmium	24,31	Cd2	11,14	cadmium	Cd2	MESH:D002104	497761(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of Cd2 + and two cadmium organic complexes on isolated rat liver mitochondria .
8481099	0	cadmium	30,37	Cd2	39,42	cadmium	Cd2	MESH:D002104	396662(Tax:9823)	Chemical	Gene	START_ENTITY|appos|+ +|compound|END_ENTITY	Surface binding and uptake of cadmium -LRB- Cd2 + -RRB- by LLC-PK1 cells on permeable membrane supports .
8588479	0	cadmium	72,79	Cd2	81,84	cadmium	Cd2	MESH:D002104	497761(Tax:10116)	Chemical	Gene	START_ENTITY|appos|+ +|compound|END_ENTITY	Influence of ethanol on the activity of glycosidases in rats exposed to cadmium -LRB- Cd2 + -RRB- .
8637391	0	cadmium	11,18	Cd2	20,23	cadmium	Cd2	MESH:D002104	12481(Tax:10090)	Chemical	Gene	START_ENTITY|appos|+ +|compound|END_ENTITY	Binding of cadmium -LRB- Cd2 + -RRB- to E-CAD1 , a calcium-binding polypeptide analog of E-cadherin .
17904100	0	cadmium	44,51	Cdc34	29,34	cadmium	Cdc34	MESH:D002104	851624(Tax:4932)	Chemical	Gene	resistance|compound|START_ENTITY mediates|dobj|resistance mediates|nsubj|END_ENTITY	Ubiquitin-conjugating enzyme Cdc34 mediates cadmium resistance in budding yeast through ubiquitination of the transcription factor Met4 .
16451733	0	cadmium	118,125	D-MEKK1	0,7	cadmium	D-MEKK1	MESH:D002104	42253(Tax:7227)	Chemical	Gene	mediate|nmod|START_ENTITY mediate|nsubj|END_ENTITY	D-MEKK1 , the Drosophila orthologue of mammalian MEKK4/MTK1 , and Hemipterous/D-MKK 7 mediate the activation of D-JNK by cadmium and arsenite in Schneider cells .
12388109	0	cadmium	34,41	DMT1	10,14	cadmium	DMT1	MESH:D002104	4891	Chemical	Gene	knockdown|nmod|START_ENTITY knockdown|nsubj|Effect Effect|nmod|END_ENTITY	Effect of DMT1 knockdown on iron , cadmium , and lead uptake in Caco-2 cells .
18076961	0	cadmium	7,14	DMT1	68,72	cadmium	DMT1	MESH:D002104	18174(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY suggests|nsubj|uptake suggests|ccomp|transporter transporter|nsubj|END_ENTITY	Normal cadmium uptake in microcytic_anemia mk/mk mice suggests that DMT1 is not the only cadmium transporter in vivo .
18076961	0	cadmium	89,96	DMT1	68,72	cadmium	DMT1	MESH:D002104	18174(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|nsubj|END_ENTITY	Normal cadmium uptake in microcytic_anemia mk/mk mice suggests that DMT1 is not the only cadmium transporter in vivo .
20654454	0	cadmium	39,46	E-Cadherin	138,148	cadmium	E-Cadherin	MESH:D002104	442858(Tax:9615)	Chemical	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|cells cells|acl:relcl|express express|dobj|levels levels|nmod|END_ENTITY	Comparison of the cytotoxic effects of cadmium -LRB- Cd -LRB- 2 + -RRB- -RRB- in high and low resistance strains of MDCK cells that express different levels of E-Cadherin .
10446391	0	cadmium	15,22	E-cadherin	108,118	cadmium	E-cadherin	MESH:D002104	12550(Tax:10090)	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|motif motif|nmod|END_ENTITY	Interaction of cadmium -LRB- Cd -LRB- 2 + -RRB- -RRB- with a 13-residue polypeptide analog of a putative calcium-binding motif of E-cadherin .
10799334	0	cadmium	45,52	E-cadherin	14,24	cadmium	E-cadherin	MESH:D002104	999	Chemical	Gene	toxicity|compound|START_ENTITY target|nmod|toxicity target|nsubj|END_ENTITY	Evidence that E-cadherin may be a target for cadmium toxicity in epithelial cells .
12570930	0	cadmium	11,18	E-cadherin	22,32	cadmium	E-cadherin	MESH:D002104	12550(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of cadmium on E-cadherin and VE-cadherin in mouse lung .
8637391	0	cadmium	11,18	E-cadherin	77,87	cadmium	E-cadherin	MESH:D002104	12550(Tax:10090)	Chemical	Gene	Binding|nmod|START_ENTITY polypeptide|advcl|Binding polypeptide|dobj|analog analog|nmod|END_ENTITY	Binding of cadmium -LRB- Cd2 + -RRB- to E-CAD1 , a calcium-binding polypeptide analog of E-cadherin .
23376140	0	cadmium	61,68	EGFR	105,109	cadmium	EGFR	MESH:D002104	13649(Tax:10090)	Chemical	Gene	toxicity|compound|START_ENTITY response|nmod|toxicity display|dobj|response display|nmod|mechanism mechanism|acl|mediated mediated|nmod|END_ENTITY	Hepatocytes display a compensatory survival response against cadmium toxicity by a mechanism mediated by EGFR and Src .
23948867	0	cadmium	53,60	EGFR	25,29	cadmium	EGFR	MESH:D002104	13649(Tax:10090)	Chemical	Gene	regulating|dobj|START_ENTITY acts|advcl|regulating acts|dobj|downstream downstream|nmod|END_ENTITY	NF-kB acts downstream of EGFR in regulating low dose cadmium induced primary lung cell proliferation .
26146868	0	cadmium	21,28	Erk1/2	43,49	cadmium	Erk1/2	MESH:D002104	5595;5594	Chemical	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Resveratrol prevents cadmium activation of Erk1/2 and JNK pathways from neuronal cell death via protein phosphatases 2A and 5 .
20299748	0	cadmium	65,72	Fibroblast_growth_factor_23	0,27	cadmium	Fibroblast growth factor 23	MESH:D002104	64654(Tax:10090)	Chemical	Gene	actions|nmod|START_ENTITY mediates|dobj|actions mediates|nsubj|END_ENTITY	Fibroblast_growth_factor_23 mediates the phosphaturic actions of cadmium .
10488566	0	cadmium	74,81	GRP94	36,41	cadmium	GRP94	MESH:D002104	362862(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	The endoplasmic reticulum chaperone GRP94 is induced in the thyrocytes by cadmium .
24834720	0	cadmium	81,88	GSH2	56,60	cadmium	GSH2	MESH:D002104	854108(Tax:4932)	Chemical	Gene	-RSB-|compound|START_ENTITY regulation|nmod|-RSB- regulation|nmod|gene gene|compound|END_ENTITY	-LSB- Transcriptional regulation of the Hansenula_polymorpha GSH2 gene in response to cadmium ion treatment -RSB- .
22319073	0	cadmium	31,38	HMT1	14,18	cadmium	HMT1	MESH:D002104	822186(Tax:3702)	Chemical	Gene	lowers|dobj|START_ENTITY lowers|nsubj|END_ENTITY	Fission_yeast HMT1 lowers seed cadmium through phytochelatin-dependent vacuolar sequestration in Arabidopsis .
18923543	0	cadmium	52,59	Iron_regulatory_protein_1	0,25	cadmium	Iron regulatory protein 1	MESH:D002104	11428(Tax:10090)	Chemical	Gene	toxicity|compound|START_ENTITY target|nmod|toxicity target|nsubj|END_ENTITY	Iron_regulatory_protein_1 is not an early target of cadmium toxicity in mice , but it is sensitive to cadmium stress in a human epithelial cell line .
20696460	0	cadmium	20,27	MSH6	114,118	cadmium	MSH6	MESH:D002104	260437(Tax:7955)	Chemical	Gene	levels|nmod|START_ENTITY down-regulate|nsubj|levels down-regulate|dobj|expression expression|appos|END_ENTITY	Sublethal levels of cadmium down-regulate the gene expression of DNA mismatch recognition protein MutS_homolog_6 -LRB- MSH6 -RRB- in zebrafish -LRB- Danio_rerio -RRB- embryos .
15513922	6	cadmium	1064,1071	Msh6	1099,1103	cadmium	Msh6	MESH:D002104	2956	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Steady state kinetic analysis with wild type Msh2-Msh6 , and with heterodimers containing subunit-specific Glu to Ala replacements inferred to inactivate the ATPase activity of either Msh2 or Msh6 , suggest that cadmium inhibits ATP hydrolysis by Msh6 but not Msh2 .
9545559	0	cadmium	132,139	N-acetyl-L-cysteine	48,67	cadmium	N-acetyl-L-cysteine	MESH:D002104	7504	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|effects effects|nmod|END_ENTITY	Concentration-dependent differential effects of N-acetyl-L-cysteine on the expression of HSP70 and metallothionein genes induced by cadmium in human amniotic cells .
11453644	0	cadmium	13,20	Nramp2	36,42	cadmium	Nramp2	MESH:D002104	4891	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|END_ENTITY	Evidence for cadmium uptake through Nramp2 : metal speciation studies with Caco-2 cells .
20371380	0	cadmium	42,49	RCK	22,25	cadmium	RCK	MESH:D002104	80122	Chemical	Gene	Structure|nmod|START_ENTITY Structure|nmod|END_ENTITY	Structure of the MthK RCK in complex with cadmium .
15664265	0	cadmium	18,25	SGLT1	133,138	cadmium	SGLT1	MESH:D002104	20537(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Adverse effect of cadmium on binding of transcription factor Sp1 to the GC-rich regions of the mouse sodium-glucose_cotransporter_1 , SGLT1 , promoter .
20060848	0	cadmium	108,115	SGLT1	55,60	cadmium	SGLT1	MESH:D002104	20537(Tax:10090)	Chemical	Gene	reaction|nmod|START_ENTITY down-regulation|dep|reaction down-regulation|nmod|Sp1 Sp1|amod|binding binding|nmod|END_ENTITY	Cadmium down-regulation of kidney Sp1 binding to mouse SGLT1 and SGLT2 gene promoters : possible reaction of cadmium with the zinc finger domain of Sp1 .
21167921	0	cadmium	11,18	SPCA	42,46	cadmium	SPCA	MESH:D002104	235574(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of cadmium on calcium transporter SPCA , calcium homeostasis and b-casein expression in the murine mammary epithelium .
20060848	0	cadmium	108,115	Sp1	147,150	cadmium	Sp1	MESH:D002104	20683(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Cadmium down-regulation of kidney Sp1 binding to mouse SGLT1 and SGLT2 gene promoters : possible reaction of cadmium with the zinc finger domain of Sp1 .
1370360	0	cadmium	94,101	TGF_beta	110,118	cadmium	TGF beta	MESH:D002104	59086(Tax:10116)	Chemical	Gene	START_ENTITY|acl|induced induced|dobj|production production|amod|END_ENTITY	Cadmium 's action on NRK-49F cells to produce responses induced also by TGF_beta is not due to cadmium induced TGF_beta production or activation .
12189181	0	cadmium	23,30	TNF-alpha	34,43	cadmium	TNF-alpha	MESH:D002104	21926(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Sensitizing effects of cadmium on TNF-alpha - and TRAIL-mediated apoptosis of NIH3T3 cells with distinct expression patterns of p53 .
1811283	0	cadmium	11,18	alcohol_dehydrogenase	22,43	cadmium	alcohol dehydrogenase	MESH:D002104	78959(Tax:10116)	Chemical	Gene	Binding|nmod|START_ENTITY Binding|acl|END_ENTITY	Binding of cadmium to alcohol_dehydrogenase in the liver before induction of metallothionein .
7049121	0	cadmium	10,17	aldehyde_reductase	48,66	cadmium	aldehyde reductase	MESH:D002104	10327	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of cadmium and phenobarbital on cerebral aldehyde_reductase .
9291654	0	cadmium	10,17	angiotensin_converting_enzyme	41,70	cadmium	angiotensin converting enzyme	MESH:D002104	24310(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of cadmium and captopril on serum angiotensin_converting_enzyme activity in rats .
1462351	0	cadmium	15,22	atrial_natriuretic_peptide	28,54	cadmium	atrial natriuretic peptide	MESH:D002104	24602(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|receptors receptors|amod|END_ENTITY	Interaction of cadmium with atrial_natriuretic_peptide receptors : implications for toxicity .
16327056	0	cadmium	21,28	beta2-microglobulin	138,157	cadmium	beta2-microglobulin	MESH:D002104	567	Chemical	Gene	Excretion|nmod|START_ENTITY Excretion|nmod|END_ENTITY	Excretion of urinary cadmium , copper , and zinc in cadmium-exposed and nonexposed subjects , with special reference to urinary excretion of beta2-microglobulin and metallothionein .
18515022	0	cadmium	61,68	beta2-microglobulin	92,111	cadmium	beta2-microglobulin	MESH:D002104	567	Chemical	Gene	Estimation|nmod|START_ENTITY Estimation|nmod|END_ENTITY	Estimation of benchmark doses as threshold levels of urinary cadmium , based on excretion of beta2-microglobulin in cadmium-polluted and non-polluted regions in Japan .
1303959	0	cadmium	37,44	beta_2-microglobulin	54,74	cadmium	beta 2-microglobulin	MESH:D002104	567	Chemical	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Critical levels of blood and urinary cadmium , urinary beta_2-microglobulin and retinol-binding protein for monitoring cadmium health effects .
10637132	0	cadmium	91,98	c-fos	82,87	cadmium	c-fos	MESH:D002104	2353	Chemical	Gene	kinase|nmod|START_ENTITY kinase|dobj|cascades cascades|nmod|END_ENTITY	Activation of parallel mitogen-activated protein kinase cascades and induction of c-fos by cadmium .
10799654	0	cadmium	26,33	c-fos	57,62	cadmium	c-fos	MESH:D002104	14281(Tax:10090)	Chemical	Gene	cytotoxicity|nmod|START_ENTITY cytotoxicity|nmod|fibroblasts fibroblasts|acl|lacking lacking|dobj|END_ENTITY	Increased cytotoxicity of cadmium in fibroblasts lacking c-fos .
11738272	0	cadmium	122,129	c-fos	57,62	cadmium	c-fos	MESH:D002104	2353	Chemical	Gene	exposed|nmod|START_ENTITY exposed|nsubj|induction induction|nmod|isoform isoform|amod|END_ENTITY	Transient induction of metallothionein isoform 3 -LRB- MT-3 -RRB- , c-fos , c-jun and c-myc in human_proximal_tubule cells exposed to cadmium .
17622784	0	cadmium	94,101	c-fos	8,13	cadmium	c-fos	MESH:D002104	314322(Tax:10116)	Chemical	Gene	exposure|compound|START_ENTITY induced|nmod|exposure stress|acl|induced independent|nmod|stress independent|nsubj|expression expression|amod|END_ENTITY	Hepatic c-fos expression is independent of oxidative stress and inflammation induced by acute cadmium exposure in rats .
9417049	0	cadmium	56,63	c-fos	13,18	cadmium	c-fos	MESH:D002104	2353	Chemical	Gene	proto-oncogene|nmod|START_ENTITY proto-oncogene|nsubj|Induction Induction|nmod|END_ENTITY	Induction of c-fos proto-oncogene in mesangial cells by cadmium .
11769627	0	cadmium	98,105	c-myc	53,58	cadmium	c-myc	MESH:D002104	24577(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY expression|acl|induced expression|amod|END_ENTITY	-LSB- Effects of selenium on hepatocellular protooncogene c-myc , c-fos and c-jun expression induced by cadmium in rats -RSB- .
8691507	0	cadmium	78,85	c-myc	13,18	cadmium	c-myc	MESH:D002104	24577(Tax:10116)	Chemical	Gene	myoblasts|nmod|START_ENTITY expression|nmod|myoblasts expression|amod|END_ENTITY	Induction of c-myc and c-jun proto-oncogene expression in rat L6 myoblasts by cadmium is inhibited by zinc preinduction of the metallothionein gene .
10383976	0	cadmium	38,45	cadD	26,30	cadmium	cadD	MESH:D002104	2610343(Tax:1280)	Chemical	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	Cloning and expression of cadD , a new cadmium resistance gene of Staphylococcus_aureus .
15232780	0	cadmium	28,35	calcitonin_gene-related_peptide	57,88	cadmium	calcitonin gene-related peptide	MESH:D002104	24241(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effect of acute exposure to cadmium on the expression of calcitonin_gene-related_peptide -LRB- CGRP -RRB- , calcitonin -LRB- CT -RRB- , somatostatin -LRB- SST -RRB- and synaptophysin -LRB- SYN -RRB- in the C cells of the rat thyroid -- a preliminary study .
14985460	0	cadmium	23,30	cholinephosphotransferase	34,59	cadmium	cholinephosphotransferase	MESH:D002104	56994	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|amod|END_ENTITY	Differential effect of cadmium on cholinephosphotransferase activity in normal and cancerous human mammary epithelial cell lines .
7302968	0	cadmium	24,31	cytochrome_P-450	58,74	cadmium	cytochrome P-450	MESH:D002104	25251(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|system system|amod|END_ENTITY	Differential effects of cadmium on the hepatic microsomal cytochrome_P-450 system in male and female rats .
12734640	0	cadmium	49,56	erythropoietin	15,29	cadmium	erythropoietin	MESH:D002104	2056	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Suppression of erythropoietin gene expression by cadmium depends on inhibition of HIF-1 , not stimulation of GATA-2 .
7857202	0	cadmium	66,73	erythropoietin	18,32	cadmium	erythropoietin	MESH:D002104	2056	Chemical	Gene	intoxication|compound|START_ENTITY anemia|nmod|intoxication contributes|nmod|anemia contributes|nsubj|Hypoproduction Hypoproduction|nmod|END_ENTITY	Hypoproduction of erythropoietin contributes to anemia in chronic cadmium intoxication : clinical study on Itai-itai_disease in Japan .
9010580	0	cadmium	10,17	erythropoietin	75,89	cadmium	erythropoietin	MESH:D002104	24335(Tax:10116)	Chemical	Gene	exposure|compound|START_ENTITY induces|nsubj|exposure induces|nmod|hypoinduction hypoinduction|nmod|END_ENTITY	Long-term cadmium exposure induces anemia in rats through hypoinduction of erythropoietin in the kidneys .
11771854	0	cadmium	21,28	estrogen_receptor	46,63	cadmium	estrogen receptor	MESH:D002104	2099	Chemical	Gene	toxicity|compound|START_ENTITY enhances|dobj|toxicity enhances|nmod|END_ENTITY	Bisphenol_A enhances cadmium toxicity through estrogen_receptor .
24692081	0	cadmium	20,27	estrogen_receptor	64,81	cadmium	estrogen receptor	MESH:D002104	2099	Chemical	Gene	Association|nmod|START_ENTITY risk|nsubj|Association risk|nmod|epidermal_growth_factor_receptor_2 epidermal_growth_factor_receptor_2|compound|END_ENTITY	Association between cadmium and breast_cancer risk according to estrogen_receptor and human epidermal_growth_factor_receptor_2 : epidemiological evidence .
8207012	0	cadmium	10,17	estrogen_receptor	21,38	cadmium	estrogen receptor	MESH:D002104	2099	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|compound|END_ENTITY	Effect of cadmium on estrogen_receptor levels and estrogen-induced responses in human breast_cancer cells .
10770491	0	cadmium	57,64	estrogen_receptor-alpha	14,37	cadmium	estrogen receptor-alpha	MESH:D002104	2099	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of estrogen_receptor-alpha by the heavy metal cadmium .
15158561	0	cadmium	73,80	glutathione_S-transferase	10,35	cadmium	glutathione S-transferase	MESH:D002104	58962(Tax:10116)	Chemical	Gene	stimulation|nmod|START_ENTITY stimulation|amod|END_ENTITY	Rat liver glutathione_S-transferase activity stimulation following acute cadmium or manganese intoxication .
16327072	0	cadmium	11,18	growth_hormone	48,62	cadmium	growth hormone	MESH:D002104	81668(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|acl|END_ENTITY	Effects of cadmium and zinc on plasma levels of growth_hormone , insulin-like_growth_factor_I , and insulin-like_growth_factor-binding_protein_3 .
21605570	0	cadmium	10,17	hOGG1	21,26	cadmium	hOGG1	MESH:D002104	4968	Chemical	Gene	Impact|nmod|START_ENTITY Impact|nmod|END_ENTITY	Impact of cadmium on hOGG1 and APE1 as a function of the cellular p53 status .
24908303	0	cadmium	57,64	interleukin-4	68,81	cadmium	interleukin-4	MESH:D002104	3565	Chemical	Gene	Evaluation|nmod|START_ENTITY Evaluation|nmod|END_ENTITY	Evaluation of the adverse effect of low concentration of cadmium on interleukin-4 induced class switch recombination in Burkett 's lymphoma Raji cell line .
24255836	0	cadmium	139,146	kidney_injury_molecule-1	11,35	cadmium	kidney injury molecule-1	MESH:D002104	26762	Chemical	Gene	Use|nmod|START_ENTITY Use|nmod|END_ENTITY	Use of the kidney_injury_molecule-1 as a biomarker for early detection of renal_tubular_dysfunction in a population chronically exposed to cadmium in the environment .
2728004	0	cadmium	88,95	metallothionein-I	21,38	cadmium	metallothionein-I	MESH:D002104	24567(Tax:10116)	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|excretion excretion|nmod|END_ENTITY	Urinary excretion of metallothionein-I and its degradation product in rats treated with cadmium , copper , zinc or mercury .
3394152	0	cadmium	135,142	metallothionein-I	43,60	cadmium	metallothionein-I	MESH:D002104	17748(Tax:10090)	Chemical	Gene	status|nmod|START_ENTITY status|nmod|gene gene|amod|END_ENTITY	Methylation status and organization of the metallothionein-I gene in livers and testes of strains of mice resistant and susceptible to cadmium .
3564038	0	cadmium	65,72	metallothionein-I	13,30	cadmium	metallothionein-I	MESH:D002104	24567(Tax:10116)	Chemical	Gene	rats|nmod|START_ENTITY Induction|nmod|rats Induction|nmod|END_ENTITY	Induction of metallothionein-I and metallothionein-II in rats by cadmium and zinc .
7096350	0	cadmium	47,54	metallothionein-I	21,38	cadmium	metallothionein-I	MESH:D002104	100689478	Chemical	Gene	cells|amod|START_ENTITY Amplification|nmod|cells Amplification|nmod|gene gene|amod|END_ENTITY	Amplification of the metallothionein-I gene in cadmium - and zinc-resistant Chinese_hamster ovary cells .
8111036	0	cadmium	51,58	metallothionein-I	20,37	cadmium	metallothionein-I	MESH:D002104	17748(Tax:10090)	Chemical	Gene	resistance|compound|START_ENTITY confers|dobj|resistance confers|nsubj|Expression Expression|nmod|gene gene|compound|END_ENTITY	Expression of mouse metallothionein-I gene confers cadmium resistance in transgenic tobacco plants .
8545831	0	cadmium	70,77	metallothionein-I	33,50	cadmium	metallothionein-I	MESH:D002104	17748(Tax:10090)	Chemical	Gene	lethality|compound|START_ENTITY protected|nmod|lethality protected|nsubjpass|END_ENTITY	Transgenic_mice that overexpress metallothionein-I are protected from cadmium lethality and hepatotoxicity .
8824913	0	cadmium	71,78	metallothionein-I	46,63	cadmium	metallothionein-I	MESH:D002104	17748(Tax:10090)	Chemical	Gene	toxicity|compound|START_ENTITY resist|dobj|toxicity END_ENTITY|xcomp|resist	Transgenic mouse blastocysts that overexpress metallothionein-I resist cadmium toxicity in vitro .
8834864	0	cadmium	116,123	metallothionein-I	45,62	cadmium	metallothionein-I	MESH:D002104	17748(Tax:10090)	Chemical	Gene	toxicology|nmod|START_ENTITY transgenic_mice|nmod|toxicology Analysis|nmod|transgenic_mice Analysis|nmod|END_ENTITY	Analysis of the effects of overexpression of metallothionein-I in transgenic_mice on the reproductive toxicology of cadmium .
8914622	0	cadmium	74,81	metallothionein-I	17,34	cadmium	metallothionein-I	MESH:D002104	17748(Tax:10090)	Chemical	Gene	sensitive|nmod|START_ENTITY sensitive|nsubj|Hepatocytes Hepatocytes|nmod|mice mice|compound|END_ENTITY	Hepatocytes from metallothionein-I and II knock-out mice are sensitive to cadmium - and tert-butylhydroperoxide-induced cytotoxicity .
9453164	0	cadmium	58,65	metallothionein-I	24,41	cadmium	metallothionein-I	MESH:D002104	17748(Tax:10090)	Chemical	Gene	resistance|compound|START_ENTITY conferring|dobj|resistance Expression|acl|conferring Expression|nmod|gene gene|compound|END_ENTITY	Expression of the mouse metallothionein-I gene conferring cadmium resistance in a transgenic cyanobacterium .
9882588	0	cadmium	11,18	metallothionein-I	22,39	cadmium	metallothionein-I	MESH:D002104	24567(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effects of cadmium on metallothionein-I and metallothionein-II mRNA expression in rat ventral , lateral , and dorsal prostatic_lobes : quantification by competitive RT-PCR .
8619234	0	cadmium	30,37	metallothionein_I	41,58	cadmium	metallothionein I	MESH:D002104	17748(Tax:10090)	Chemical	Gene	Distribution|nmod|START_ENTITY Distribution|nmod|END_ENTITY	Distribution and retention of cadmium in metallothionein_I and II null mice .
22387671	0	cadmium	9,16	mt2	34,37	cadmium	mt2	MESH:D002104	100174951(Tax:7955)	Chemical	Gene	exposure|compound|START_ENTITY induces|nsubj|exposure induces|dobj|expression expression|amod|END_ENTITY	Maternal cadmium exposure induces mt2 and smtB mRNA expression in zebrafish -LRB- Danio_rerio -RRB- females and their offspring .
21987117	0	cadmium	71,78	myeloperoxidase	25,40	cadmium	myeloperoxidase	MESH:D002104	4353	Chemical	Gene	investigation|nmod|START_ENTITY investigation|nmod|END_ENTITY	Kinetic investigation of myeloperoxidase upon interaction with copper , cadmium , and lead ions .
25446071	0	cadmium	10,17	p63	73,76	cadmium	p63	MESH:D002104	8626	Chemical	Gene	Impact|nmod|START_ENTITY Impact|nmod|END_ENTITY	Impact of cadmium , cobalt and nickel on sequence-specific DNA binding of p63 and p73 in vitro and in cells .
16949638	0	cadmium	85,92	peroxidase	31,41	cadmium	peroxidase	MESH:D002104	548137(Tax:4513)	Chemical	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	Rhizosphere localized cationic peroxidase from barley roots is strongly activated by cadmium and correlated with root growth inhibition .
10207616	0	cadmium	30,37	prolactin	50,59	cadmium	prolactin	MESH:D002104	24683(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|secretion secretion|compound|END_ENTITY	Pubertal dependent effects of cadmium on episodic prolactin secretion in male rats .
10365372	0	cadmium	31,38	prolactin	77,86	cadmium	prolactin	MESH:D002104	24683(Tax:10116)	Chemical	Gene	exposure|compound|START_ENTITY alternating|dobj|exposure alternating|nmod|secretion secretion|nmod|END_ENTITY	Effects of chronic alternating cadmium exposure on the episodic secretion of prolactin in male rats .
10831224	0	cadmium	34,41	prolactin	93,102	cadmium	prolactin	MESH:D002104	24683(Tax:10116)	Chemical	Gene	exposure|compound|START_ENTITY Effects|nmod|exposure Effects|nmod|END_ENTITY	Effects of subchronic alternating cadmium exposure on dopamine turnover and plasma levels of prolactin , GH and ACTH .
12224762	0	cadmium	16,23	prolactin	59,68	cadmium	prolactin	MESH:D002104	24683(Tax:10116)	Chemical	Gene	exposure|compound|START_ENTITY Effects|nmod|exposure puberty|nsubj|Effects puberty|nmod|END_ENTITY	Effects of oral cadmium exposure through puberty on plasma prolactin and gonadotropin levels and amino_acid contents in various brain areas in pubertal male rats .
12530588	0	cadmium	5,12	prolactin	71,80	cadmium	prolactin	MESH:D002104	24683(Tax:10116)	Chemical	Gene	exposure|compound|START_ENTITY inhibit|nsubj|exposure inhibit|dobj|secretion secretion|nmod|END_ENTITY	Oral cadmium exposure throughout puberty does not inhibit secretion of prolactin , GH and ACTH through dopamine metabolism changes in male rat .
15585363	0	cadmium	17,24	prolactin	82,91	cadmium	prolactin	MESH:D002104	24683(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|secretion secretion|compound|END_ENTITY	Toxic effects of cadmium on the regulatory mechanism of dopamine and serotonin on prolactin secretion in adult male rats .
12520955	0	cadmium	12,19	proto-oncogene_c-fos	41,61	cadmium	proto-oncogene c-fos	MESH:D002104	314322(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of cadmium on the expression of proto-oncogene_c-fos and c-jun of liver cell in rats -RSB- .
1321627	0	cadmium	17,24	renin	32,37	cadmium	renin	MESH:D002104	24715(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|system system|compound|END_ENTITY	Acute effects of cadmium on the renin angiotensin system in rats .
9441733	0	cadmium	37,44	renin	86,91	cadmium	renin	MESH:D002104	24715(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|compound|END_ENTITY	Effect of repeated administration of cadmium , captopril and its combination on plasma renin activity in rats .
15664265	0	cadmium	18,25	sodium-glucose_cotransporter_1	101,131	cadmium	sodium-glucose cotransporter 1	MESH:D002104	20537(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|amod|END_ENTITY	Adverse effect of cadmium on binding of transcription factor Sp1 to the GC-rich regions of the mouse sodium-glucose_cotransporter_1 , SGLT1 , promoter .
15521073	0	cadmium	68,75	thioredoxin_reductase_1	30,53	cadmium	thioredoxin reductase 1	MESH:D002104	7296	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Transcriptional regulation of thioredoxin_reductase_1 expression by cadmium in vascular endothelial cells : role of NF-E2-related_factor-2 .
18261755	0	cadmium	16,23	valosin-containing_protein	32,58	cadmium	valosin-containing protein	MESH:D002104	7415	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	The heavy metal cadmium induces valosin-containing_protein -LRB- VCP -RRB- - mediated aggresome formation .
170355	0	cadmium	11,18	vasopressin	88,99	cadmium	vasopressin	MESH:D002104	551	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of cadmium of the hydro-osmotic and natriferic responses to the toad bladder to vasopressin .
24518829	0	cadmium-metallothionein	69,92	hNGAL_receptor	46,60	cadmium-metallothionein	hNGAL receptor	null	51310	Chemical	Gene	ligands|amod|START_ENTITY ligands|compound|END_ENTITY	Differential transcytosis and toxicity of the hNGAL_receptor ligands cadmium-metallothionein and cadmium-phytochelatin in colon-like Caco-2 cells : implications for in vivo cadmium toxicity .
22041583	0	cadmium_chloride	12,28	astrocyte-elevated_gene-1	40,65	cadmium chloride	astrocyte-elevated gene-1	MESH:D019256	92140	Chemical	Gene	Exposure|nmod|START_ENTITY influences|nsubj|Exposure influences|dobj|expression expression|amod|END_ENTITY	Exposure to cadmium_chloride influences astrocyte-elevated_gene-1 -LRB- AEG-1 -RRB- expression in MDA-MB231 human breast_cancer cells .
2362955	0	caerulein	61,70	CCK	74,77	caerulein	CCK	MESH:D002108	885	Chemical	Gene	START_ENTITY|appos|analogue analogue|compound|END_ENTITY	Effect of intracerebroventricular and systemic injections of caerulein , a CCK analogue , on electrical self-stimulation and its interaction with the CCKA receptor antagonist , L-364 ,718 -LRB- MK-329 -RRB- .
2470456	0	caerulein	54,63	CCK	23,26	caerulein	CCK	MESH:D002108	25298(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY Effect|nmod|secretion Effect|nmod|END_ENTITY	Effect of a new potent CCK antagonist , lorglumide , on caerulein - and bombesin-induced pancreatic secretion and growth in the rat .
3208830	0	caerulein	44,53	CCK	10,13	caerulein	CCK	MESH:D002108	25298(Tax:10116)	Chemical	Gene	abolished|dobj|START_ENTITY abolished|nsubj|L364 L364|compound|END_ENTITY	The novel CCK antagonist L364 ,718 abolished caerulein - but potentiates morphine-induced antinociception .
6606162	0	caerulein	3,12	CCK	23,26	caerulein	CCK	MESH:D002108	885	Chemical	Gene	amphibian|compound|START_ENTITY END_ENTITY|nsubj|amphibian	Is caerulein amphibian CCK ?
7870888	0	caerulein	90,99	CCK	115,118	caerulein	CCK	MESH:D002108	25298(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|nmod|receptors receptors|compound|END_ENTITY	Ondansetron , an antagonist of 5-HT3 receptors , antagonizes the anti-exploratory effect of caerulein , an agonist of CCK receptors , in the elevated plus-maze .
3096866	0	caerulein	10,19	TRH	45,48	caerulein	TRH	MESH:D002108	7200	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|response response|nmod|END_ENTITY	Effect of caerulein on pituitary response to TRH in humans .
6974244	0	caerulein	10,19	gastrin	21,28	caerulein	gastrin	MESH:D002108	2520	Chemical	Gene	Action|nmod|START_ENTITY END_ENTITY|nsubj|Action	Action of caerulein , gastrin 17 , pentagastrin , and secretin on the active transport of sodium by the frog skin .
344181	0	caerulein	10,19	insulin	25,32	caerulein	insulin	MESH:D002108	483665(Tax:9615)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of caerulein upon insulin and glucagon secretion in dogs .
5487026	0	caerulein	15,24	insulin	28,35	caerulein	insulin	MESH:D002108	483665(Tax:9615)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|secretion secretion|compound|END_ENTITY	The effects of caerulein on insulin secretion in anaesthetized dogs .
3175063	0	caerulein	32,41	neurotensin	15,26	caerulein	neurotensin	MESH:D002108	299757(Tax:10116)	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of neurotensin with caerulein or secretin on digestive tract growth in rats .
6146548	0	caerulein	10,19	somatostatin	52,64	caerulein	somatostatin	MESH:D002108	403993(Tax:9615)	Chemical	Gene	administration|compound|START_ENTITY Effect|nmod|administration Effect|nmod|END_ENTITY	Effect of caerulein administration on portal plasma somatostatin in dogs .
26197161	0	caffeic_acid	71,83	5-lipoxygenase	97,111	caffeic acid	5-lipoxygenase	MESH:C040048	240	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Design , synthesis and evaluation of semi-synthetic triazole-containing caffeic_acid analogues as 5-lipoxygenase inhibitors .
26197161	0	caffeic_acid	71,83	5-lipoxygenase	97,111	caffeic acid	5-lipoxygenase	MESH:C040048	240	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Design , synthesis and evaluation of semi-synthetic triazole-containing caffeic_acid analogues as 5-lipoxygenase inhibitors .
3441482	0	caffeic_acid	36,48	Dopa_decarboxylase	14,32	caffeic acid	Dopa decarboxylase	MESH:C040048	1644	Chemical	Gene	compounds|amod|START_ENTITY END_ENTITY|nmod|compounds	Inhibition of Dopa_decarboxylase by caffeic_acid and related compounds : structure-activity relationships .
22217871	0	caffeic_acid	28,40	cyclooxygenase-2	55,71	caffeic acid	cyclooxygenase-2	MESH:C040048	5743	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Enzymatic transformation of caffeic_acid with enhanced cyclooxygenase-2 inhibitory activity .
26638042	0	caffeic_acid	57,69	cyclooxygenase-2	92,108	caffeic acid	cyclooxygenase-2	MESH:C040048	5743	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|acl|END_ENTITY	Discovery of novel hybrids of diaryl-1 ,2,4 - triazoles and caffeic_acid as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase for cancer therapy .
24262883	0	caffeic_acid	21,33	neuraminidase	65,78	caffeic acid	neuraminidase	MESH:C040048	4758	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Further discovery of caffeic_acid derivatives as novel influenza neuraminidase inhibitors .
23231684	0	caffeic_acid_phenethyl_ester	50,78	Toll-like_receptor_4	15,35	caffeic acid phenethyl ester	Toll-like receptor 4	MESH:C055494	7099	Chemical	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Suppression of Toll-like_receptor_4 activation by caffeic_acid_phenethyl_ester is mediated by interference of LPS binding to MD2 .
21458432	0	caffeic_acid_phenethyl_ester	31,59	tyrosinase	79,89	caffeic acid phenethyl ester	tyrosinase	MESH:C055494	7299	Chemical	Gene	START_ENTITY|acl|mediated mediated|nmod|END_ENTITY	The metabolic bioactivation of caffeic_acid_phenethyl_ester -LRB- CAPE -RRB- mediated by tyrosinase selectively inhibits glutathione_S-transferase .
21490707	0	caffeine	106,114	AHR	54,57	caffeine	AHR	MESH:D002110	196	Chemical	Gene	consumption|compound|START_ENTITY determinants|nmod|consumption identifies|nmod|determinants identifies|dobj|regions regions|nmod|7p21 7p21|appos|END_ENTITY	Genome-wide meta-analysis identifies regions on 7p21 -LRB- AHR -RRB- and 15q24 -LRB- CYP1A2 -RRB- as determinants of habitual caffeine consumption .
10233211	0	caffeine	107,115	CYP1A2	83,89	caffeine	CYP1A2	MESH:D002110	1544	Chemical	Gene	tested|nmod|START_ENTITY gene|acl|tested gene|compound|END_ENTITY	Functional significance of a C -- > A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine .
10375757	0	caffeine	7,15	CYP1A2	71,77	caffeine	CYP1A2	MESH:D002110	1544	Chemical	Gene	Use|nmod|START_ENTITY Use|nmod|probe probe|nmod|determination determination|nmod|activity activity|compound|END_ENTITY	Use of caffeine as a probe for rapid determination of cytochrome P-450 CYP1A2 activity in humans .
10376760	0	caffeine	94,102	CYP1A2	31,37	caffeine	CYP1A2	MESH:D002110	1544	Chemical	Gene	test|compound|START_ENTITY using|dobj|test Estimation|acl|using Estimation|nmod|activity activity|compound|END_ENTITY	Estimation of cytochrome P-450 CYP1A2 activity in 863 healthy Caucasians using a saliva-based caffeine test .
10416066	0	caffeine	83,91	CYP1A2	142,148	caffeine	CYP1A2	MESH:D002110	1544	Chemical	Gene	Validation|nmod|START_ENTITY Validation|nmod|serum serum|nmod|context context|nmod|phenotyping phenotyping|compound|END_ENTITY	Validation of a high-performance liquid chromatography assay for quantification of caffeine and paraxanthine in human serum in the context of CYP1A2 phenotyping .
10471069	0	caffeine	22,30	CYP1A2	104,110	caffeine	CYP1A2	MESH:D002110	1544	Chemical	Gene	metabolism|compound|START_ENTITY modelling|nmod|metabolism modelling|dep|lack lack|nmod|polymorphism polymorphism|nmod|END_ENTITY	Detailed modelling of caffeine metabolism and examination of the CYP1A2 gene : lack of a polymorphism in CYP1A2 in Caucasians .
10471069	0	caffeine	22,30	CYP1A2	65,71	caffeine	CYP1A2	MESH:D002110	1544	Chemical	Gene	metabolism|compound|START_ENTITY modelling|nmod|metabolism modelling|nmod|gene gene|compound|END_ENTITY	Detailed modelling of caffeine metabolism and examination of the CYP1A2 gene : lack of a polymorphism in CYP1A2 in Caucasians .
10741629	0	caffeine	139,147	CYP1A2	37,43	caffeine	CYP1A2	MESH:D002110	1544	Chemical	Gene	metabolism|compound|START_ENTITY determination|nmod|metabolism Effect|dep|determination Effect|nmod|END_ENTITY	Effect of age and smoking on in vivo CYP1A2 , flavin-containing monooxygenase , and xanthine oxidase activities in Koreans : determination by caffeine metabolism .
10942180	0	caffeine	14,22	CYP1A2	47,53	caffeine	CYP1A2	MESH:D002110	1544	Chemical	Gene	START_ENTITY|nmod|probe probe|nmod|END_ENTITY	Evaluation of caffeine as an in vivo probe for CYP1A2 using measurements in plasma , saliva , and urine .
11470995	0	caffeine	7,15	CYP1A2	109,115	caffeine	CYP1A2	MESH:D002110	1544	Chemical	Gene	ratio|compound|START_ENTITY associated|nsubj|ratio associated|nmod|polymorphisms polymorphisms|nmod|END_ENTITY	Plasma caffeine metabolite ratio -LRB- 17X/137X -RRB- in vivo associated with G-2964A and C734A polymorphisms of human CYP1A2 .
11476124	0	caffeine	33,41	CYP1A2	0,6	caffeine	CYP1A2	MESH:D002110	1544	Chemical	Gene	test|compound|START_ENTITY measured|nmod|test measured|advmod|as as|nmod:npmod|activity activity|nummod|END_ENTITY	CYP1A2 activity as measured by a caffeine test predicts clozapine and active metabolite steady-state concentrationin patients with schizophrenia .
11682234	0	caffeine	20,28	CYP1A2	92,98	caffeine	CYP1A2	MESH:D002110	1544	Chemical	Gene	Analysis|nmod|START_ENTITY metabolites|nsubj|Analysis metabolites|parataxis|assess assess|dobj|activity activity|nummod|END_ENTITY	Analysis of urinary caffeine metabolites by HPLC-DAD : the use of metabolic ratios to assess CYP1A2 enzyme activity .
12110375	0	caffeine	15,23	CYP1A2	77,83	caffeine	CYP1A2	MESH:D002110	13077(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY Differences|nmod|metabolism Differences|nmod|END_ENTITY	Differences in caffeine and paraxanthine metabolism between human and murine CYP1A2 .
12172216	0	caffeine	57,65	CYP1A2	72,78	caffeine	CYP1A2	MESH:D002110	1544	Chemical	Gene	alias|compound|START_ENTITY 3-demthylation|nmod|alias END_ENTITY|amod|3-demthylation	The interindividual differences in the 3-demthylation of caffeine alias CYP1A2 is determined by both genetic and environmental factors .
12451287	0	caffeine	41,49	CYP1A2	83,89	caffeine	CYP1A2	MESH:D002110	1544	Chemical	Gene	rate|nmod|START_ENTITY Influence|nmod|rate metabolite|nsubj|Influence metabolite|dobj|ratios ratios|acl|used used|xcomp|assess assess|dobj|activity activity|compound|END_ENTITY	Influence of the urine flow rate on some caffeine metabolite ratios used to assess CYP1A2 activity .
12534642	0	caffeine	162,170	CYP1A2	37,43	caffeine	CYP1A2	MESH:D002110	1544	Chemical	Gene	metabolism|compound|START_ENTITY disequilibrium|nmod|metabolism frequencies|appos|disequilibrium Polymorphisms|dep|frequencies Polymorphisms|nmod|gene gene|compound|END_ENTITY	Polymorphisms in the cytochrome P450 CYP1A2 gene -LRB- CYP1A2 -RRB- in colorectal_cancer patients and controls : allele frequencies , linkage disequilibrium and influence on caffeine metabolism .
12534642	0	caffeine	162,170	CYP1A2	50,56	caffeine	CYP1A2	MESH:D002110	1544	Chemical	Gene	metabolism|compound|START_ENTITY disequilibrium|nmod|metabolism frequencies|appos|disequilibrium Polymorphisms|dep|frequencies Polymorphisms|nmod|gene gene|appos|END_ENTITY	Polymorphisms in the cytochrome P450 CYP1A2 gene -LRB- CYP1A2 -RRB- in colorectal_cancer patients and controls : allele frequencies , linkage disequilibrium and influence on caffeine metabolism .
1302044	0	caffeine	21,29	CYP1A2	98,104	caffeine	CYP1A2	MESH:D002110	1544	Chemical	Gene	Biotransformation|nmod|START_ENTITY Biotransformation|nmod|END_ENTITY	Biotransformation of caffeine , paraxanthine , theobromine and theophylline by cDNA-expressed human CYP1A2 and CYP2E1 .
1306111	0	caffeine	80,88	CYP1A2	17,23	caffeine	CYP1A2	MESH:D002110	1544	Chemical	Gene	metabolites|compound|START_ENTITY analysis|nmod|metabolites phenotypes|nmod|analysis phenotypes|nsubj|Determination Determination|nmod|END_ENTITY	Determination of CYP1A2 and NAT2 phenotypes in human populations by analysis of caffeine urinary metabolites .
14616429	0	caffeine	11,19	CYP1A2	82,88	caffeine	CYP1A2	MESH:D002110	1544	Chemical	Gene	intake|compound|START_ENTITY Effects|nmod|intake Effects|nmod|pharmacokinetics pharmacokinetics|nmod|melatonin melatonin|appos|drug drug|nmod|activity activity|compound|END_ENTITY	Effects of caffeine intake on the pharmacokinetics of melatonin , a probe drug for CYP1A2 activity .
15619608	0	caffeine	41,49	CYP1A2	72,78	caffeine	CYP1A2	MESH:D002110	24297(Tax:10116)	Chemical	Gene	clearance|compound|START_ENTITY predict|dobj|clearance test|acl|predict Application|nmod|test mediated|nsubj|Application mediated|nmod|END_ENTITY	Application of the PKCYP test to predict caffeine clearance mediated by CYP1A2 in a rat acute liver_injury model .
16153396	0	caffeine	46,54	CYP1A2	27,33	caffeine	CYP1A2	MESH:D002110	1544	Chemical	Gene	ratio|compound|START_ENTITY affects|dobj|ratio affects|nsubj|polymorphism polymorphism|nmod|END_ENTITY	The G-113A polymorphism in CYP1A2 affects the caffeine metabolic ratio in a Chinese population .
16458123	0	caffeine	106,114	CYP1A2	118,124	caffeine	CYP1A2	MESH:D002110	24297(Tax:10116)	Chemical	Gene	hepatocarcinogenesis|nmod|START_ENTITY Lack|dep|hepatocarcinogenesis Lack|appos|inducer inducer|compound|END_ENTITY	Lack of modification of 2-amino-3 ,8 - dimethylimidazo -LSB- 4,5-f -RSB- quinoxaline -LRB- MeIQx -RRB- rat hepatocarcinogenesis by caffeine , a CYP1A2 inducer , points to complex counteracting influences .
17040215	0	caffeine	10,18	CYP1A2	97,103	caffeine	CYP1A2	MESH:D002110	1544	Chemical	Gene	intake|compound|START_ENTITY Effect|nmod|intake Effect|nmod|END_ENTITY	Effect of caffeine intake 12 or 24 hours prior to melatonin intake and CYP1A2 * 1F polymorphism on CYP1A2 phenotyping by melatonin .
17221922	0	caffeine	134,142	CYP1A2	22,28	caffeine	CYP1A2	MESH:D002110	1544	Chemical	Gene	ratios|compound|START_ENTITY monitoring|nmod|ratios oxidase|nmod|monitoring oxidase|nmod|evaluation evaluation|nmod|END_ENTITY	In vivo evaluation of CYP1A2 , CYP2A6 , NAT-2 and xanthine oxidase activities in a Greek population sample by the RP-HPLC monitoring of caffeine metabolic ratios .
1934864	0	caffeine	7,15	CYP1A2	45,51	caffeine	CYP1A2	MESH:D002110	1544	Chemical	Gene	Use|nmod|START_ENTITY metabolite|nsubj|Use metabolite|xcomp|explore explore|dobj|activities activities|compound|END_ENTITY	Use of caffeine metabolite ratios to explore CYP1A2 and xanthine oxidase activities .
21490707	0	caffeine	106,114	CYP1A2	70,76	caffeine	CYP1A2	MESH:D002110	1544	Chemical	Gene	consumption|compound|START_ENTITY determinants|nmod|consumption identifies|nmod|determinants identifies|dobj|regions regions|nmod|7p21 7p21|appos|END_ENTITY	Genome-wide meta-analysis identifies regions on 7p21 -LRB- AHR -RRB- and 15q24 -LRB- CYP1A2 -RRB- as determinants of habitual caffeine consumption .
21827488	0	caffeine	20,28	CYP1A2	95,101	caffeine	CYP1A2	MESH:D002110	1544	Chemical	Gene	Pharmacokinetics|nmod|START_ENTITY Pharmacokinetics|nmod|metrics metrics|nummod|END_ENTITY	Pharmacokinetics of caffeine in plasma and saliva , and the influence of caffeine abstinence on CYP1A2 metrics .
22420682	0	caffeine	67,75	CYP1A2	19,25	caffeine	CYP1A2	MESH:D002110	1544	Chemical	Gene	effects|nmod|START_ENTITY influence|nmod|effects influence|nmod|polymorphism polymorphism|compound|END_ENTITY	The influence of a CYP1A2 polymorphism on the ergogenic effects of caffeine .
22554278	0	caffeine	43,51	CYP1A2	15,21	caffeine	CYP1A2	MESH:D002110	1544	Chemical	Gene	focus|nmod|START_ENTITY Measurement|dep|focus Measurement|nmod|activity activity|compound|END_ENTITY	Measurement of CYP1A2 activity : a focus on caffeine as a probe .
22673010	0	caffeine	114,122	CYP1A2	11,17	caffeine	CYP1A2	MESH:D002110	1544	Chemical	Gene	using|dobj|START_ENTITY administration|acl|using humans|nmod|administration activity|nmod|humans activity|nummod|END_ENTITY	Changes in CYP1A2 activity in humans after 3,4-methylenedioxymethamphetamine -LRB- MDMA , ecstasy -RRB- administration using caffeine as a probe drug .
25025048	0	caffeine	51,59	CYP1A2	109,115	caffeine	CYP1A2	MESH:D002110	1544	Chemical	Gene	START_ENTITY|appos|substrate substrate|nmod|cytochrome_P450_1A2 cytochrome_P450_1A2|amod|unrelated unrelated|nmod|END_ENTITY	Quercetin significantly inhibits the metabolism of caffeine , a substrate of cytochrome_P450_1A2 unrelated to CYP1A2 * 1C -LRB- -2964 G > A -RRB- and * 1F -LRB- 734C > A -RRB- gene polymorphisms .
25891161	0	caffeine	94,102	CYP1A2	63,69	caffeine	CYP1A2	MESH:D002110	1544	Chemical	Gene	validation|nmod|START_ENTITY validation|nmod|method method|nmod|END_ENTITY	Development and validation of a reversed-phase HPLC method for CYP1A2 phenotyping by use of a caffeine metabolite ratio in saliva .
26029007	0	caffeine	79,87	CYP1A2	31,37	caffeine	CYP1A2	MESH:D002110	1544	Chemical	Gene	effects|nmod|START_ENTITY polymorphism|nmod|effects polymorphism|compound|END_ENTITY	Erratum to : The influence of a CYP1A2 polymorphism on the ergogenic effects of caffeine .
26038236	0	caffeine	12,20	CYP1A2	108,114	caffeine	CYP1A2	MESH:D002110	1544	Chemical	Gene	Analysis|nmod|START_ENTITY Analysis|nmod|chromatography chromatography|nmod|phenotyping phenotyping|compound|END_ENTITY	Analysis of caffeine and paraxanthine in human saliva with ultra-high-performance liquid chromatography for CYP1A2 phenotyping .
26048820	0	caffeine	18,26	CYP1A2	113,119	caffeine	CYP1A2	MESH:D002110	1544	Chemical	Gene	Quantification|nmod|START_ENTITY Quantification|nmod|Resonance Resonance|nmod|method method|nmod|phenotyping phenotyping|compound|END_ENTITY	Quantification of caffeine in human saliva by Nuclear Magnetic Resonance as an alternative method for cytochrome CYP1A2 phenotyping .
7548239	0	caffeine	58,66	CYP1A2	21,27	caffeine	CYP1A2	MESH:D002110	24297(Tax:10116)	Chemical	Gene	administration|nmod|START_ENTITY END_ENTITY|nmod|administration	Induction of hepatic CYP1A2 by the oral administration of caffeine to rats : lack of association with the Ah locus .
7720764	0	caffeine	46,54	CYP1A2	33,39	caffeine	CYP1A2	MESH:D002110	1544	Chemical	Gene	using|dobj|START_ENTITY END_ENTITY|acl|using	A population and family study of CYP1A2 using caffeine urinary metabolites .
7893591	0	caffeine	68,76	CYP1A2	36,42	caffeine	CYP1A2	MESH:D002110	1544	Chemical	Gene	test|compound|START_ENTITY determined|nmod|test determined|nsubj|covaries covaries|nmod|activity activity|compound|END_ENTITY	Clozapine disposition covaries with CYP1A2 activity determined by a caffeine test .
7920209	0	caffeine	60,68	CYP1A2	143,149	caffeine	CYP1A2	MESH:D002110	1544	Chemical	Gene	metabolites|compound|START_ENTITY analysis|nmod|metabolites population|nmod|analysis CYP1A2|nmod|population Phenotyping|nmod|CYP1A2 Phenotyping|dep|absence absence|nmod|mutation mutation|acl|prescribing prescribing|dobj|phenotype phenotype|nmod|gene gene|compound|END_ENTITY	Phenotyping of CYP1A2 in Japanese population by analysis of caffeine urinary metabolites : absence of mutation prescribing the phenotype in the CYP1A2 gene .
7920209	0	caffeine	60,68	CYP1A2	15,21	caffeine	CYP1A2	MESH:D002110	1544	Chemical	Gene	metabolites|compound|START_ENTITY analysis|nmod|metabolites population|nmod|analysis END_ENTITY|nmod|population	Phenotyping of CYP1A2 in Japanese population by analysis of caffeine urinary metabolites : absence of mutation prescribing the phenotype in the CYP1A2 gene .
8485024	0	caffeine	110,118	CYP1A2	79,85	caffeine	CYP1A2	MESH:D002110	1544	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|nummod|END_ENTITY	Inhibitory effect of grapefruit juice and its bitter principal , naringenin , on CYP1A2 dependent metabolism of caffeine in man .
8799528	0	caffeine	78,86	CYP1A2	0,6	caffeine	CYP1A2	MESH:D002110	1544	Chemical	Gene	toxicity|nmod|START_ENTITY influencing|dobj|toxicity variables|acl|influencing activity|nmod|variables activity|nummod|END_ENTITY	CYP1A2 activity , gender and smoking , as variables influencing the toxicity of caffeine .
8873215	0	caffeine	18,26	CYP1A2	8,14	caffeine	CYP1A2	MESH:D002110	13077(Tax:10090)	Chemical	Gene	pharmacokinetics|compound|START_ENTITY END_ENTITY|nmod|pharmacokinetics	Role of CYP1A2 in caffeine pharmacokinetics and metabolism : studies using mice deficient in CYP1A2 .
8873215	0	caffeine	18,26	CYP1A2	92,98	caffeine	CYP1A2	MESH:D002110	13077(Tax:10090)	Chemical	Gene	pharmacokinetics|compound|START_ENTITY CYP1A2|nmod|pharmacokinetics Role|nmod|CYP1A2 Role|dep|studies studies|acl|using using|dobj|deficient deficient|nmod|END_ENTITY	Role of CYP1A2 in caffeine pharmacokinetics and metabolism : studies using mice deficient in CYP1A2 .
9156694	0	caffeine	14,22	CYP1A2	42,48	caffeine	CYP1A2	MESH:D002110	1544	Chemical	Gene	START_ENTITY|nmod|drug drug|nmod|END_ENTITY	Evaluation of caffeine as a test drug for CYP1A2 , NAT2 and CYP2E1 phenotyping in man by in vivo versus in vitro correlations .
9491835	0	caffeine	68,76	CYP1A2	13,19	caffeine	CYP1A2	MESH:D002110	1544	Chemical	Gene	test|compound|START_ENTITY using|dobj|test Induction|acl|using Induction|nmod|activity activity|nummod|END_ENTITY	Induction of CYP1A2 activity by carbamazepine in children using the caffeine breath test .
2412614	0	caffeine	11,19	Ca2	27,30	caffeine	Ca2	MESH:D002110	54231(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|+ +|amod|END_ENTITY	-LSB- Effect of caffeine on the Ca2 + - transport function of sarcoplasmic reticulum vesicles in the rat myocardium -RSB- .
9782158	0	caffeine	11,19	Ca2	47,50	caffeine	Ca2	MESH:D002110	760	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|+ +|amod|END_ENTITY	Effects of caffeine and adenine_nucleotides on Ca2 + release by the sarcoplasmic reticulum in saponin-permeabilized frog skeletal muscle fibres .
9441719	0	caffeine	15,23	Cyp1a2	101,107	caffeine	Cyp1a2	MESH:D002110	13077(Tax:10090)	Chemical	Gene	activity|compound|START_ENTITY Differences|nmod|activity Differences|dep|comparison comparison|nmod|expression expression|amod|END_ENTITY	Differences in caffeine 3-demethylation activity among inbred mouse strains : a comparison of hepatic Cyp1a2 gene expression between two inbred strains .
15060176	0	caffeine	96,104	DNA-PK	58,64	caffeine	DNA-PK	MESH:D002110	5591	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|appos|END_ENTITY	Selective inhibition of the DNA-dependent_protein_kinase -LRB- DNA-PK -RRB- by the radiosensitizing agent caffeine .
15060176	0	caffeine	96,104	DNA-dependent_protein_kinase	28,56	caffeine	DNA-dependent protein kinase	MESH:D002110	5591	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Selective inhibition of the DNA-dependent_protein_kinase -LRB- DNA-PK -RRB- by the radiosensitizing agent caffeine .
14605666	0	caffeine	49,57	PTEN	20,24	caffeine	PTEN	MESH:D002110	5728	Chemical	Gene	treatment|nmod|START_ENTITY treatment|compound|END_ENTITY	Adenovirus-mediated PTEN treatment combined with caffeine produces a synergistic therapeutic effect in colorectal_cancer cells .
25686090	0	caffeine	58,66	Snq2p	34,39	caffeine	Snq2p	MESH:D002110	851574(Tax:4932)	Chemical	Gene	efflux|compound|START_ENTITY mediate|dobj|efflux mediate|nsubj|END_ENTITY	Multidrug resistance transporters Snq2p and Pdr5p mediate caffeine efflux in Saccharomyces_cerevisiae .
18258404	0	caffeine	9,17	acetylcholinesterase	33,53	caffeine	acetylcholinesterase	MESH:D002110	83817(Tax:10116)	Chemical	Gene	intake|compound|START_ENTITY affects|nsubj|intake affects|dobj|END_ENTITY	Maternal caffeine intake affects acetylcholinesterase in hippocampus of neonate rats .
2003276	0	caffeine	38,46	acetylcholinesterase	14,34	caffeine	acetylcholinesterase	MESH:D002110	43	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of acetylcholinesterase by caffeine , anabasine , methyl_pyrrolidine and their derivatives .
25451122	0	caffeine	9,17	acetylcholinesterase	73,93	caffeine	acetylcholinesterase	MESH:D002110	83817(Tax:10116)	Chemical	Gene	alters|compound|START_ENTITY neuromotor|nsubj|alters neuromotor|dobj|activity activity|compound|END_ENTITY	Maternal caffeine exposure alters neuromotor development and hippocampus acetylcholinesterase activity in rat offspring .
26620258	0	caffeine	85,93	acetylcholinesterase	15,35	caffeine	acetylcholinesterase	MESH:D002110	43	Chemical	Gene	effect|nmod|START_ENTITY Involvement|nmod|effect Involvement|nmod|END_ENTITY	Involvement of acetylcholinesterase and protein_kinase_C in the protective effect of caffeine against b-amyloid-induced alterations in red blood cells .
1425965	0	caffeine	34,42	angiotensin_II	66,80	caffeine	angiotensin II	MESH:D002110	24179(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|responses responses|nmod|END_ENTITY	Effects of chronic treatment with caffeine on kidney responses to angiotensin_II .
7972292	0	caffeine	14,22	corticotropin-releasing_factor	62,92	caffeine	corticotropin-releasing factor	MESH:D002110	81648(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|involvement involvement|nmod|END_ENTITY	The effect of caffeine on food intake in rats : involvement of corticotropin-releasing_factor and the sympatho-adrenal system .
10233204	0	caffeine	8,16	cytochrome_P4501A2	52,70	caffeine	cytochrome P4501A2	MESH:D002110	1544	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Dietary caffeine as a probe agent for assessment of cytochrome_P4501A2 activity in random urine samples .
7742721	0	caffeine	40,48	cytochrome_P4501A2	83,101	caffeine	cytochrome P4501A2	MESH:D002110	1544	Chemical	Gene	variation|nmod|START_ENTITY Analysis|nmod|variation metabolism|nsubj|Analysis metabolism|advcl|used used|xcomp|determine determine|dobj|activities activities|amod|END_ENTITY	Analysis of within-subject variation of caffeine metabolism when used to determine cytochrome_P4501A2 and N-acetyltransferase-2 activities .
8738764	0	caffeine	40,48	cytochrome_P4501A2	71,89	caffeine	cytochrome P4501A2	MESH:D002110	1544	Chemical	Gene	Determination|nmod|START_ENTITY Determination|nmod|assessment assessment|nmod|oxidase oxidase|amod|END_ENTITY	Determination of urinary metabolites of caffeine for the assessment of cytochrome_P4501A2 , xanthine oxidase , and N-acetyltransferase activity in humans .
10837004	0	caffeine	114,122	cytochrome_P450_1A2	63,82	caffeine	cytochrome P450 1A2	MESH:D002110	1544	Chemical	Gene	ratios|compound|START_ENTITY changes|nmod|ratios vegetables|dep|changes vegetables|acl:relcl|decrease decrease|dobj|activity activity|amod|END_ENTITY	Brassica vegetables increase and apiaceous vegetables decrease cytochrome_P450_1A2 activity in humans : changes in caffeine metabolite ratios in response to controlled vegetable diets .
11147835	0	caffeine	15,23	cytochrome_P450_1A2	56,75	caffeine	cytochrome P450 1A2	MESH:D002110	1544	Chemical	Gene	START_ENTITY|nmod|site site|nmod|END_ENTITY	Orientation of caffeine within the active site of human cytochrome_P450_1A2 based on NMR longitudinal -LRB- T1 -RRB- relaxation measurements .
14674790	0	caffeine	153,161	cytochrome_P450_1A2	191,210	caffeine	cytochrome P450 1A2	MESH:D002110	1544	Chemical	Gene	clearance|compound|START_ENTITY clearance|nmod|biomarker biomarker|nmod|activity activity|amod|END_ENTITY	Nonparametric expectation maximisation -LRB- NPEM -RRB- population pharmacokinetic analysis of caffeine disposition from sparse data in adult caucasians : systemic caffeine clearance as a biomarker for cytochrome_P450_1A2 activity .
14674790	0	caffeine	85,93	cytochrome_P450_1A2	191,210	caffeine	cytochrome P450 1A2	MESH:D002110	1544	Chemical	Gene	disposition|compound|START_ENTITY analysis|nmod|disposition maximisation|dep|analysis maximisation|dep|clearance clearance|nmod|biomarker biomarker|nmod|activity activity|amod|END_ENTITY	Nonparametric expectation maximisation -LRB- NPEM -RRB- population pharmacokinetic analysis of caffeine disposition from sparse data in adult caucasians : systemic caffeine clearance as a biomarker for cytochrome_P450_1A2 activity .
19520064	0	caffeine	10,18	cytochrome_P450_1A2	40,59	caffeine	cytochrome P450 1A2	MESH:D002110	13077(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effect of caffeine on the expression of cytochrome_P450_1A2 , adenosine_A2A_receptor and dopamine_transporter in control and 1-methyl_4-phenyl_1 , _ 2 , _ 3 , _ 6-tetrahydropyridine treated mouse striatum .
21591074	0	caffeine	22,30	cytochrome_P450_1A2	71,90	caffeine	cytochrome P450 1A2	MESH:D002110	1544	Chemical	Gene	determination|nmod|START_ENTITY determination|dep|assay assay|nmod|activity activity|amod|END_ENTITY	HPLC determination of caffeine and paraxanthine in urine : An assay for cytochrome_P450_1A2 activity .
25025048	0	caffeine	51,59	cytochrome_P450_1A2	76,95	caffeine	cytochrome P450 1A2	MESH:D002110	1544	Chemical	Gene	START_ENTITY|appos|substrate substrate|nmod|END_ENTITY	Quercetin significantly inhibits the metabolism of caffeine , a substrate of cytochrome_P450_1A2 unrelated to CYP1A2 * 1C -LRB- -2964 G > A -RRB- and * 1F -LRB- 734C > A -RRB- gene polymorphisms .
9334905	0	caffeine	82,90	cytochrome_P450_1A2	37,56	caffeine	cytochrome P450 1A2	MESH:D002110	1544	Chemical	Gene	modelling|nmod|START_ENTITY modelling|nmod|END_ENTITY	Three-dimensional modelling of human cytochrome_P450_1A2 and its interaction with caffeine and MeIQ .
21573684	0	caffeine	24,32	demethylase	46,57	caffeine	demethylase	MESH:D002110	8932	Chemical	Gene	degradation|nmod|START_ENTITY END_ENTITY|nsubj|degradation	Enhanced degradation of caffeine and caffeine demethylase production by Pseudomonas sp .
16059590	0	caffeine	28,36	event-related_potential	62,85	caffeine	event-related potential	MESH:D002110	2004	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	-LSB- Neuromodulatory effects of caffeine and bromazepam on visual event-related_potential -LRB- P300 -RRB- : a comparative study -RSB- .
18840375	0	caffeine	49,57	growth_hormone	114,128	caffeine	growth hormone	MESH:D002110	2688	Chemical	Gene	START_ENTITY|acl|phenotyping phenotyping|nmod|deficiency deficiency|amod|END_ENTITY	Six-month , prospective , longitudinal , open-label caffeine and dextromethorphan phenotyping study in children with growth_hormone deficiency receiving recombinant human growth_hormone replacement .
18840375	0	caffeine	49,57	growth_hormone	168,182	caffeine	growth hormone	MESH:D002110	2688	Chemical	Gene	START_ENTITY|acl|phenotyping phenotyping|advcl|receiving receiving|dobj|replacement replacement|compound|END_ENTITY	Six-month , prospective , longitudinal , open-label caffeine and dextromethorphan phenotyping study in children with growth_hormone deficiency receiving recombinant human growth_hormone replacement .
1974194	0	caffeine	28,36	growth_hormone	10,24	caffeine	growth hormone	MESH:D002110	81668(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY Effect|nmod|metabolism Effect|nmod|END_ENTITY	Effect of growth_hormone on caffeine metabolism in hypophysectomized rats .
2496962	0	caffeine	121,129	growth_hormone	10,24	caffeine	growth hormone	MESH:D002110	2688	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|therapy therapy|amod|END_ENTITY	Effect of growth_hormone therapy in growth_hormone-deficient children on cytochrome P-450-dependent 3-N-demethylation of caffeine as measured by the caffeine 13CO2 breath test .
2496962	0	caffeine	149,157	growth_hormone	10,24	caffeine	growth hormone	MESH:D002110	2688	Chemical	Gene	test|compound|START_ENTITY measured|nmod|test Effect|acl|measured Effect|nmod|therapy therapy|amod|END_ENTITY	Effect of growth_hormone therapy in growth_hormone-deficient children on cytochrome P-450-dependent 3-N-demethylation of caffeine as measured by the caffeine 13CO2 breath test .
4320973	8	caffeine	1021,1029	growth_hormone	1072,1086	caffeine	growth hormone	MESH:D002110	81668(Tax:10116)	Chemical	Gene	cyclic_AMP|nmod|START_ENTITY caused|nsubj|cyclic_AMP caused|dobj|increase increase|nmod|release release|compound|END_ENTITY	Dibutyryl cyclic_AMP , with or without caffeine , caused an up to 300 % increase in labeled growth_hormone release .
969704	0	caffeine	15,23	insulin	37,44	caffeine	insulin	MESH:D002110	3630	Chemical	Gene	START_ENTITY|nmod|level level|compound|END_ENTITY	-LSB- The effect of caffeine on the serum insulin level during intravenous glucose tolerance test in patients with chemical diabetes -RSB- .
20038063	0	caffeine	25,33	myoglobin	39,48	caffeine	myoglobin	MESH:D002110	4151	Chemical	Gene	Study|nmod|START_ENTITY Study|nmod|END_ENTITY	-LSB- Study on interaction of caffeine with myoglobin by fluorescence spectroscopy -RSB- .
23788688	0	caffeine	47,55	parathyroid_hormone	14,33	caffeine	parathyroid hormone	MESH:D002110	5741	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of parathyroid_hormone secretion by caffeine in human parathyroid cells .
1815652	0	caffeine	14,22	renin	37,42	caffeine	renin	MESH:D002110	5972	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|concentration concentration|compound|END_ENTITY	The effect of caffeine on renal vein renin concentration in patients with renal_arterial_disease .
22841599	0	caffeine	33,41	semicarbazide-sensitive_amine_oxidase	79,116	caffeine	semicarbazide-sensitive amine oxidase	MESH:D002110	29473(Tax:10116)	Chemical	Gene	Distribution|nmod|START_ENTITY Distribution|nmod|END_ENTITY	Distribution and accumulation of caffeine in rat tissues and its inhibition on semicarbazide-sensitive_amine_oxidase .
22100783	0	caffeine	35,43	steroidogenic_acute_regulatory_protein	47,85	caffeine	steroidogenic acute regulatory protein	MESH:D002110	6770	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|compound|END_ENTITY	Inheritable stimulatory effects of caffeine on steroidogenic_acute_regulatory_protein expression and cortisol production in human adrenocortical cells .
23272120	0	caffeine	22,30	surfactant_protein_B	68,88	caffeine	surfactant protein B	MESH:D002110	6439	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|mRNA mRNA|compound|END_ENTITY	Synergistic effect of caffeine and glucocorticoids on expression of surfactant_protein_B -LRB- SP-B -RRB- mRNA .
11330688	0	caffeine	22,30	tumor_necrosis_factor-alpha	69,96	caffeine	tumor necrosis factor-alpha	MESH:D002110	21926(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY induced|nsubj|effect induced|nmod|END_ENTITY	Suppressive effect of caffeine on hepatitis and apoptosis induced by tumor_necrosis_factor-alpha , but not by the anti-Fas antibody , in mice .
26412184	0	caffeine_citrate	12,28	myelin_basic_protein	32,52	caffeine citrate	myelin basic protein	MESH:C026189	24547(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of caffeine_citrate on myelin_basic_protein in neonatal rats with hypoxic-ischemic_brain_damage -RSB- .
24085498	0	caffeoyl	23,31	prolyl_oligopeptidase	71,92	caffeoyl	prolyl oligopeptidase	null	5550	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	In vitro evaluation of caffeoyl and cinnamoyl derivatives as potential prolyl_oligopeptidase inhibitors .
16903851	0	calcineurin	54,65	BK_channel	14,24	calcineurin	BK channel	CHEBI:53439	83731(Tax:10116)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activity activity|compound|END_ENTITY	Inhibition of BK_channel activity by association with calcineurin in rat brain .
12617961	0	calcineurin	33,44	Bcl-2	50,55	calcineurin	Bcl-2	CHEBI:53439	12043(Tax:10090)	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Calcium-dependent interaction of calcineurin with Bcl-2 in neuronal tissue .
21517850	0	calcineurin	16,27	CA3	12,15	calcineurin	CA3	CHEBI:53439	54232(Tax:10116)	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Hippocampal CA3 calcineurin activity participates in depressive-like behavior in rats .
10931822	3	calcineurin	534,545	Cain	483,487	calcineurin	cain	CHEBI:53439	23523	Chemical	Gene	inhibitor|nmod|START_ENTITY inhibitor|nsubj|END_ENTITY	Cain is a recently identified protein inhibitor of calcineurin .
22851699	0	calcineurin	11,22	FHL2	0,4	calcineurin	FHL2	CHEBI:53439	14200(Tax:10090)	Chemical	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	FHL2 binds calcineurin and represses pathological cardiac growth .
22875481	0	calcineurin	14,25	mTOR	92,96	calcineurin	mTOR	CHEBI:53439	21977(Tax:10090)	Chemical	Gene	Inhibition|nmod|START_ENTITY induced|nsubj|Inhibition induced|nmod|END_ENTITY	Inhibition of calcineurin in the prefrontal cortex induced depressive-like behavior through mTOR signaling pathway .
26081515	0	calcipotriol	12,24	S100A8	46,52	calcipotriol	S100A8	MESH:C055085	6279	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of calcipotriol on the expression of S100A8 in human keratinocytes -RSB- .
26875609	0	calcipotriol	68,80	Zinc_finger_protein_A20	0,23	calcipotriol	Zinc finger protein A20	MESH:C055085	7128	Chemical	Gene	effect|nmod|START_ENTITY involved|nmod|effect involved|nsubjpass|END_ENTITY	Zinc_finger_protein_A20 is involved in the anti-psoriatic effect of calcipotriol .
20182640	0	calcipotriol	14,26	beta_defensin-2	54,69	calcipotriol	beta defensin-2	MESH:C055085	1673	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|nmod|END_ENTITY	The effect of calcipotriol on the expression of human beta_defensin-2 and LL-37 in cultured human keratinocytes .
24419155	4	calcipotriol	463,475	hCAP18	555,561	calcipotriol	hCAP18	MESH:C055085	820	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	However , the effect of calcipotriol on the mRNA expression/production of human cathelicidin antimicrobial protein -LRB- hCAP18 -RRB- and LL37 peptide by IL-17A / IL-22-stimulated keratinocytes remains controversial .
16684279	0	calcipotriol	15,27	p53	71,74	calcipotriol	p53	MESH:C055085	7157	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|compound|END_ENTITY	The effects of calcipotriol and methylprednisolone_aseponate on bcl-2 , p53 and ki-67 expression in psoriasis .
15055995	0	calcipotriol	102,114	vitamin_D_nuclear_receptor	26,52	calcipotriol	vitamin D nuclear receptor	MESH:C055085	7421	Chemical	Gene	structures|amod|START_ENTITY structures|nmod|END_ENTITY	Crystal structures of the vitamin_D_nuclear_receptor liganded with the vitamin_D side chain analogues calcipotriol and seocalcitol , receptor agonists of clinical importance .
23135000	0	calcipotriol	23,35	vitiligo	96,104	calcipotriol	vitiligo	MESH:C055085	246319	Chemical	Gene	START_ENTITY|nmod|treatment treatment|nmod|END_ENTITY	The effect of combined calcipotriol and betamethasone_dipropionate ointment in the treatment of vitiligo : an open , uncontrolled trial .
20595020	0	calcite	49,56	otoconin_90	32,43	calcite	otoconin 90	MESH:D002119	729330	Chemical	Gene	growth|amod|START_ENTITY END_ENTITY|nmod|growth	In vitro effects of recombinant otoconin_90 upon calcite crystal growth .
21423046	0	calcitonin	23,33	CALCA	35,40	calcitonin	CALCA	MESH:D002116	796	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Methylation pattern of calcitonin -LRB- CALCA -RRB- gene in pediatric acute_leukemia .
15099400	0	calcitonin	120,130	CaSR	105,109	calcitonin	CaSR	MESH:D002116	12374(Tax:10090)	Chemical	Gene	release|compound|START_ENTITY regulates|dobj|release regulates|nsubj|END_ENTITY	Physiological studies in heterozygous calcium_sensing_receptor -LRB- CaSR -RRB- gene-ablated mice confirm that the CaSR regulates calcitonin release in vivo .
3015365	0	calcitonin	61,71	Calcitonin_gene-related_peptide	0,31	calcitonin	Calcitonin gene-related peptide	MESH:D002116	24241(Tax:10116)	Chemical	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	Calcitonin_gene-related_peptide -LRB- CGRP -RRB- acts independently of calcitonin on cyclic_AMP formation in clonal osteogenic_sarcoma cells -LRB- UMR 106-01 -RRB- .
9184643	0	calcitonin	54,64	IL-6	27,31	calcitonin	IL-6	MESH:D002116	3569	Chemical	Gene	induced|nmod|START_ENTITY production|acl|induced production|compound|END_ENTITY	Protein kinase A-dependent IL-6 production induced by calcitonin in human glioblastoma A172 cells .
18407176	0	calcitonin	24,34	PTH	57,60	calcitonin	PTH	MESH:D002116	5741	Chemical	Gene	START_ENTITY|appos|parathyroid_hormone parathyroid_hormone|appos|END_ENTITY	Receptors for secretin , calcitonin , parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide , vasoactive intestinal peptide , glucagonlike peptide 1 , growth_hormone-releasing_hormone , and glucagon belong to a newly discovered G-protein-linked receptor family .
9448108	0	calcitonin	52,62	alkaline_phosphatase	19,39	calcitonin	alkaline phosphatase	MESH:D002116	100860026	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|activity activity|amod|END_ENTITY	Dual regulation of alkaline_phosphatase activity by calcitonin in porcine kidney cells .
1313684	0	calcitonin	33,43	beta-endorphin	52,66	calcitonin	beta-endorphin	MESH:D002116	5443	Chemical	Gene	suppression|nmod|START_ENTITY induced|nsubj|suppression induced|dobj|secretion secretion|amod|END_ENTITY	Dexamethasone suppression of the calcitonin induced beta-endorphin , ACTH and cortisol secretion .
16575494	0	calcitonin	14,24	beta-endorphin	28,42	calcitonin	beta-endorphin	MESH:D002116	5443	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|levels levels|amod|END_ENTITY	The effect of calcitonin on beta-endorphin levels in postmenopausal_osteoporotic patients with back_pain .
1491396	0	calcitonin	10,20	beta_2_microglobulin	68,88	calcitonin	beta 2 microglobulin	MESH:D002116	567	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of calcitonin or the anabolic_steroid Decadurabolin on serum beta_2_microglobulin in osteoporotic postmenopausal women .
3930032	0	calcitonin	38,48	beta_2_microglobulin	58,78	calcitonin	beta 2 microglobulin	MESH:D002116	567	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|concentration concentration|amod|END_ENTITY	Influence of pharmacological doses of calcitonin on serum beta_2_microglobulin concentration .
9164825	0	calcitonin	44,54	c-fos	14,19	calcitonin	c-fos	MESH:D002116	2353	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of c-fos and c-jun expression by calcitonin in human breast_cancer cells .
17114906	0	calcitonin	48,58	gastrin	30,37	calcitonin	gastrin	MESH:D002116	2520	Chemical	Gene	secretion|compound|START_ENTITY effects|nmod|secretion effects|nmod|levels levels|compound|END_ENTITY	Long-term effects of elevated gastrin levels on calcitonin secretion .
2098841	0	calcitonin	11,21	gastrin	72,79	calcitonin	gastrin	MESH:D002116	2520	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|emptying emptying|nmod|END_ENTITY	-LSB- Effect of calcitonin on gastric emptying and postprandial secretion of gastrin and insulin in patients with duodenal ulcer -RSB- .
6260615	0	calcitonin	108,118	gastrin	88,95	calcitonin	gastrin	MESH:D002116	2520	Chemical	Gene	levels|compound|START_ENTITY containing|nmod|levels containing|dobj|tetrapeptide tetrapeptide|nmod|END_ENTITY	Effect of exogenous gastrointestinal peptides containing the C-terminal tetrapeptide of gastrin on calcium , calcitonin and parathormone serum levels in man .
7024392	0	calcitonin	28,38	gastrin	57,64	calcitonin	gastrin	MESH:D002116	2520	Chemical	Gene	administration|compound|START_ENTITY administration|nmod|insulin insulin|amod|END_ENTITY	Effects of synthetic salmon calcitonin administration on gastrin , immunoreactive insulin and growth_hormone release after protein meal in uremic patients .
7367817	0	calcitonin	46,56	gastrin	18,25	calcitonin	gastrin	MESH:D002116	2520	Chemical	Gene	secretion|nmod|START_ENTITY END_ENTITY|nmod|secretion	The role of serum gastrin in the secretion of calcitonin : studies in patients with pernicious anaemia and in healthy subjects .
2627752	0	calcitonin	14,24	growth_hormone	28,42	calcitonin	growth hormone	MESH:D002116	2688	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|amod|END_ENTITY	The effect of calcitonin on growth_hormone secretion in acromegaly .
2908103	0	calcitonin	14,24	growth_hormone	28,42	calcitonin	growth hormone	MESH:D002116	2688	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|amod|END_ENTITY	The effect of calcitonin on growth_hormone secretion in man .
1686733	0	calcitonin	21,31	growth_hormone_releasing_hormone	62,94	calcitonin	growth hormone releasing hormone	MESH:D002116	2691	Chemical	Gene	effect|nmod|START_ENTITY effect|acl|END_ENTITY	Inhibitory effect of calcitonin on growth hormone response to growth_hormone_releasing_hormone in acromegaly .
1934528	0	calcitonin	105,115	growth_hormone_releasing_hormone	15,47	calcitonin	growth hormone releasing hormone	MESH:D002116	2691	Chemical	Gene	levels|compound|START_ENTITY unaltered|nmod|levels unaltered|nsubj|response response|nmod|END_ENTITY	GH response to growth_hormone_releasing_hormone and hypoglycaemia is unaltered by high endogenous plasma calcitonin levels in patients with medullary_thyroid_carcinoma .
499636	0	calcitonin	10,20	insulin	24,31	calcitonin	insulin	MESH:D002116	3630	Chemical	Gene	START_ENTITY|nmod|response response|compound|END_ENTITY	Effect of calcitonin on insulin response to arginine in man .
12865304	0	calcitonin	114,124	otoconin-22	128,139	calcitonin	otoconin-22	MESH:D002116	447090(Tax:8355)	Chemical	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	Molecular cloning of otoconin-22 complementary deoxyribonucleic acid in the bullfrog endolymphatic sac : effect of calcitonin on otoconin-22 messenger ribonucleic acid levels .
12865304	0	calcitonin	114,124	otoconin-22	21,32	calcitonin	otoconin-22	MESH:D002116	447090(Tax:8355)	Chemical	Gene	effect|nmod|START_ENTITY cloning|dep|effect cloning|nmod|acid acid|amod|END_ENTITY	Molecular cloning of otoconin-22 complementary deoxyribonucleic acid in the bullfrog endolymphatic sac : effect of calcitonin on otoconin-22 messenger ribonucleic acid levels .
20490785	0	calcitonin	38,48	parathyroid_hormone	17,36	calcitonin	parathyroid hormone	MESH:D002116	5741	Chemical	Gene	assessment|appos|START_ENTITY assessment|nmod|END_ENTITY	An assessment of parathyroid_hormone , calcitonin , _ 1,25 _ -LRB- OH -RRB- 2_vitamin_D3 , estradiol and testosterone in men with active calcium_stone disease and evaluation of its biochemical risk factors .
2632617	0	calcitonin	20,30	parathyroid_hormone	38,57	calcitonin	parathyroid hormone	MESH:D002116	19226(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nmod|effects	In vitro effects of calcitonin and/or parathyroid_hormone on odontogenesis of mouse embryonic molars .
3450531	0	calcitonin	56,66	parathyroid_hormone	19,38	calcitonin	parathyroid hormone	MESH:D002116	5741	Chemical	Gene	concentration|nmod|START_ENTITY concentration|compound|END_ENTITY	The effect of high parathyroid_hormone concentration on calcitonin in patients with primary_hyperparathyroidism .
8055364	0	calcitonin	56,66	parathyroid_hormone	25,44	calcitonin	parathyroid hormone	MESH:D002116	5741	Chemical	Gene	exogenous|nsubj|START_ENTITY exogenous|ccomp|END_ENTITY	The effect of endogenous parathyroid_hormone , exogenous calcitonin , and dibutyryl_cyclic_AMP on urinary excretion of N-acetyl-beta-D-glucosaminidase .
3255550	0	calcitonin	73,83	prolactin	42,51	calcitonin	prolactin	MESH:D002116	24683(Tax:10116)	Chemical	Gene	response|nmod|START_ENTITY Effect|nmod|response Effect|nmod|release release|nmod|END_ENTITY	Effect of thyroidectomy on the release of prolactin in vitro response to calcitonin .
2898190	0	calcitonin	41,51	somatostatin	11,23	calcitonin	somatostatin	MESH:D002116	24797(Tax:10116)	Chemical	Gene	secretion|compound|START_ENTITY Effects|nmod|secretion Effects|nmod|END_ENTITY	Effects of somatostatin and serotonin on calcitonin secretion from cultured rat parafollicular cells .
19056816	0	calcitriol	158,168	MIS	111,114	calcitriol	MIS	MESH:D002117	268	Chemical	Gene	regulation|nmod|START_ENTITY Interaction|dep|regulation Interaction|nmod|vitamin_D_receptor vitamin_D_receptor|nmod|element element|nmod|promoter promoter|appos|END_ENTITY	Interaction of the vitamin_D_receptor with a vitamin_D response element in the Mullerian-inhibiting_substance -LRB- MIS -RRB- promoter : regulation of MIS expression by calcitriol in prostate_cancer cells .
19056816	0	calcitriol	158,168	MIS	140,143	calcitriol	MIS	MESH:D002117	268	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Interaction of the vitamin_D_receptor with a vitamin_D response element in the Mullerian-inhibiting_substance -LRB- MIS -RRB- promoter : regulation of MIS expression by calcitriol in prostate_cancer cells .
12753272	0	calcitriol	56,66	PTH	80,83	calcitriol	PTH	MESH:D002117	5741	Chemical	Gene	dose|nmod|START_ENTITY adjusting|dobj|dose adjusting|nmod|levels levels|compound|END_ENTITY	Advantages of adjusting the initial dose of intravenous calcitriol according to PTH levels .
12944103	0	calcitriol	87,97	PTH	58,61	calcitriol	PTH	MESH:D002117	5741	Chemical	Gene	acting|nmod|START_ENTITY acting|dobj|END_ENTITY	A calcium homeostasis model : orchestration of fast acting PTH and calcitonin with slow calcitriol .
15125031	0	calcitriol	113,123	PTH	0,3	calcitriol	PTH	MESH:D002117	5741	Chemical	Gene	therapy|amod|START_ENTITY effects|nmod|therapy secretion|dep|effects secretion|compound|END_ENTITY	PTH secretion in patients with chronic_renal_failure assessed by a modified CiCa clamp method : effects of 1-year calcitriol therapy .
17498002	0	calcitriol	32,42	PTH	46,49	calcitriol	PTH	MESH:D002117	5741	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Effects of 22-oxacalcitriol and calcitriol on PTH secretion and bone mineral metabolism in a crossover trial in hemodialysis patients with secondary_hyperparathyroidism .
8731112	0	calcitriol	50,60	PTH	20,23	calcitriol	PTH	MESH:D002117	24694(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY effects|nmod|production effects|nmod|END_ENTITY	Relative effects of PTH and dietary phosphorus on calcitriol production in normal and azotemic rats .
8856210	0	calcitriol	67,77	PTH	19,22	calcitriol	PTH	MESH:D002117	24694(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|interaction interaction|nmod|END_ENTITY	The interaction of PTH and dietary phosphorus and calcium on serum calcitriol levels in the rat with experimental renal_failure .
23392891	0	calcitriol	35,45	TauT	27,31	calcitriol	TauT	MESH:D002117	106504129	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of TauT by calcitriol and retinoic_acid via VDR/RXR in LLC-PK1 and MCF-7 cells .
15728789	0	calcitriol	22,32	growth_hormone	55,69	calcitriol	growth hormone	MESH:D002117	81668(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|therapy therapy|amod|END_ENTITY	Daily or intermittent calcitriol administration during growth_hormone therapy in rats with renal_failure and advanced secondary_hyperparathyroidism .
26956363	0	calcitriol	14,24	high_mobility_group_box_1	28,53	calcitriol	high mobility group box 1	MESH:D002117	25459(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|amod|END_ENTITY	The effect of calcitriol on high_mobility_group_box_1 expression in periodontal ligament cells during orthodontic tooth movement in rats .
2128950	0	calcitriol	10,20	insulin	24,31	calcitriol	insulin	MESH:D002117	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of calcitriol on insulin secretion in uraemia .
25246913	0	calcitriol	15,25	insulin	44,51	calcitriol	insulin	MESH:D002117	3630	Chemical	Gene	START_ENTITY|nmod|improvement improvement|nmod|resistance resistance|compound|END_ENTITY	The effects of calcitriol on improvement of insulin resistance , ovulation and comparison with metformin therapy in PCOS patients : a randomized placebo - controlled clinical trial .
8840306	0	calcitriol	25,35	interleukin-1_beta	74,92	calcitriol	interleukin-1 beta	MESH:D002117	3553	Chemical	Gene	START_ENTITY|nmod|secretion secretion|nmod|END_ENTITY	Comparison of effects of calcitriol and calcium_carbonate on secretion of interleukin-1_beta and tumour necrosis factor-alpha by uraemic peripheral blood mononuclear cells .
1762307	0	calcitriol	67,77	parathyroid_hormone	21,40	calcitriol	parathyroid hormone	MESH:D002117	24694(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY response|dep|role response|acl|END_ENTITY	Calcemic response to parathyroid_hormone in renal_failure : role of calcitriol and the effect of parathyroidectomy .
3681111	0	calcitriol	85,95	parathyroid_hormone	21,40	calcitriol	parathyroid hormone	MESH:D002117	24694(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY response|dep|role response|acl|END_ENTITY	Calcemic response to parathyroid_hormone in spontaneously hypertensive rats : role of calcitriol .
16675575	0	calcitriol	10,20	prostate-specific_antigen	24,49	calcitriol	prostate-specific antigen	MESH:D002117	354	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of calcitriol on prostate-specific_antigen in vitro and in humans .
19134349	0	calcitriol	12,22	vitamin_D_receptor	44,62	calcitriol	vitamin D receptor	MESH:D002117	7421	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of calcitriol on the expression of vitamin_D_receptor , RANKL and osteoprotegerin in human periodontal ligament cells -RSB- .
19141646	0	calcitriol	63,73	vitamin_D_receptor	8,26	calcitriol	vitamin D receptor	MESH:D002117	22337(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nmod|effects	Role of vitamin_D_receptor in the antiproliferative effects of calcitriol in tumor-derived endothelial cells and tumor angiogenesis in vivo .
6705736	0	calcium	76,83	25-hydroxyvitamin_D3-1_alpha-hydroxylase	23,63	calcium	25-hydroxyvitamin D3-1 alpha-hydroxylase	MESH:D002118	13115(Tax:10090)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|activity activity|amod|END_ENTITY	Abnormal regulation of 25-hydroxyvitamin_D3-1_alpha-hydroxylase activity by calcium and calcitonin in renal cortex from hypophosphatemic -LRB- Hyp -RRB- mice .
2845484	0	calcium	53,60	5-Lipoxygenase	0,14	calcium	5-Lipoxygenase	MESH:D002118	240	Chemical	Gene	ions|compound|START_ENTITY effects|nmod|ions synthesis|dep|effects synthesis|amod|END_ENTITY	5-Lipoxygenase and leukotriene synthesis : effects of calcium ions and of inhibitors .
2959118	0	calcium	81,88	5-Lipoxygenase	0,14	calcium	5-Lipoxygenase	MESH:D002118	240	Chemical	Gene	presence|nmod|START_ENTITY membrane|nmod|presence END_ENTITY|advcl|membrane	5-Lipoxygenase from human leukocytes associates with membrane in the presence of calcium .
10194365	0	calcium	21,28	5-lipoxygenase	0,14	calcium	5-lipoxygenase	MESH:D002118	240	Chemical	Gene	START_ENTITY|nsubj|binds binds|amod|END_ENTITY	5-lipoxygenase binds calcium .
10984486	0	calcium	46,53	5-lipoxygenase	25,39	calcium	5-lipoxygenase	MESH:D002118	240	Chemical	Gene	START_ENTITY|nsubj|domain domain|nmod|binds binds|amod|END_ENTITY	The N-terminal domain of 5-lipoxygenase binds calcium and mediates calcium stimulation of enzyme activity .
10984486	0	calcium	67,74	5-lipoxygenase	25,39	calcium	5-lipoxygenase	MESH:D002118	240	Chemical	Gene	stimulation|compound|START_ENTITY calcium|dobj|stimulation calcium|nsubj|domain domain|nmod|binds binds|amod|END_ENTITY	The N-terminal domain of 5-lipoxygenase binds calcium and mediates calcium stimulation of enzyme activity .
11807011	0	calcium	47,54	5-lipoxygenase	14,28	calcium	5-lipoxygenase	MESH:D002118	240	Chemical	Gene	independent|advmod|START_ENTITY independent|nsubj|Activation Activation|nmod|stress stress|amod|END_ENTITY	Activation of 5-lipoxygenase by cell stress is calcium independent in human polymorphonuclear leukocytes .
1318349	0	calcium	52,59	5-lipoxygenase	119,133	calcium	5-lipoxygenase	MESH:D002118	240	Chemical	Gene	transients|compound|START_ENTITY transients|dep|involvement involvement|nmod|products products|amod|END_ENTITY	Platelet activating factor stimulates intracellular calcium transients in human neutrophils : involvement of endogenous 5-lipoxygenase products .
15219851	0	calcium	20,27	5-lipoxygenase	67,81	calcium	5-lipoxygenase	MESH:D002118	240	Chemical	Gene	domains|compound|START_ENTITY domains|nmod|END_ENTITY	Characterization of calcium and magnesium binding domains of human 5-lipoxygenase .
1654095	0	calcium	24,31	5-lipoxygenase	78,92	calcium	5-lipoxygenase	MESH:D002118	240	Chemical	Gene	Influx|nmod|START_ENTITY required|nsubjpass|Influx required|nmod|translocation translocation|nmod|synthesis synthesis|amod|END_ENTITY	Influx of extracellular calcium is required for the membrane translocation of 5-lipoxygenase and leukotriene synthesis .
1902789	0	calcium	33,40	5-lipoxygenase	61,75	calcium	5-lipoxygenase	MESH:D002118	240	Chemical	Gene	involvement|nmod|START_ENTITY involvement|nmod|formation formation|nmod|metabolites metabolites|amod|END_ENTITY	The involvement of extracellular calcium in the formation of 5-lipoxygenase metabolites by human polymorphonuclear leukocytes .
2127729	0	calcium	155,162	5-lipoxygenase	55,69	calcium	5-lipoxygenase	MESH:D002118	240	Chemical	Gene	ionophore|compound|START_ENTITY induced|nmod|ionophore leukocytes|acl|induced arachidonic_acid|nmod|leukocytes -RSB-|amod|arachidonic_acid metabolites|nmod|-RSB- metabolites|amod|END_ENTITY	-LSB- Role of exogenous arachidonate in the biosynthesis of 5-lipoxygenase metabolites of arachidonic_acid by human polymorphonuclear leukocytes induced by the calcium ionophore A23187 -RSB- .
8273581	0	calcium	75,82	5-lipoxygenase	10,24	calcium	5-lipoxygenase	MESH:D002118	25290(Tax:10116)	Chemical	Gene	stimulation|compound|START_ENTITY biosynthesis|nmod|stimulation inhibitors|nmod|biosynthesis inhibitors|nsubj|Effect Effect|nmod|END_ENTITY	Effect of 5-lipoxygenase inhibitors on in situ LTB4 biosynthesis following calcium ionophore stimulation in the rat pleural_cavity .
8626407	2	calcium	382,389	5-lipoxygenase	509,523	calcium	5-lipoxygenase	MESH:D002118	240	Chemical	Gene	ionophore|compound|START_ENTITY stimulated|nmod|ionophore cells|acl|stimulated formation|nmod|cells 5|dep|formation inhibited|dobj|5 inhibited|nmod|presence presence|nmod|exogenous exogenous|acl|arachidonic_acid arachidonic_acid|xcomp|indicating indicating|ccomp|modulated modulated|dobj|activity activity|amod|END_ENTITY	Six separate inhibitors of tyrosine_kinase each inhibited 5 -LRB- S -RRB- - hydroxyeicosatetraenoic_acid formation by HL-60 cells stimulated with calcium ionophore , in the presence or absence of exogenous arachidonic_acid substrate , indicating that they modulated cellular 5-lipoxygenase activity .
9044439	0	calcium	76,83	5-lipoxygenase	2,16	calcium	5-lipoxygenase	MESH:D002118	240	Chemical	Gene	raises|dobj|START_ENTITY raises|nsubj|inhibitor inhibitor|amod|END_ENTITY	A 5-lipoxygenase inhibitor at micromolar concentration raises intracellular calcium in U937 cells prior to their physiologic cell death .
10822315	0	calcium	285,292	ACE	26,29	calcium	ACE	MESH:D002118	1636	Chemical	Gene	blockers|compound|START_ENTITY using|dobj|blockers patients|acl|using shown|nmod|patients OBJECTIVE|parataxis|shown OBJECTIVE|nsubj|blockers blockers|appos|inhibitors inhibitors|compound|END_ENTITY	Calcium channel blockers , ACE inhibitors , and the risk of cancer in hypertensive patients : a report from the Department of Health Hypertension Care Computing Project -LRB- DHCCP -RRB- OBJECTIVE : Recent studies have shown inconsistent results on the risk of cancer in hypertensive patients using calcium channel blockers -LRB- CCBs -RRB- and angiotensin-converting_enzyme -LRB- ACE -RRB- inhibitors .
12135325	0	calcium	80,87	ACE	137,140	calcium	ACE	MESH:D002118	24310(Tax:10116)	Chemical	Gene	antagonist|compound|START_ENTITY antagonist|dep|effects effects|nmod|END_ENTITY	Combination therapy with an angiotensin-converting_enzyme -LRB- ACE -RRB- inhibitor and a calcium antagonist : beyond the renoprotective effects of ACE inhibitor monotherapy in a spontaneous hypertensive rat with renal_ablation .
12454378	0	calcium	93,100	ACE	78,81	calcium	ACE	MESH:D002118	1636	Chemical	Gene	antagonist|dep|START_ENTITY antagonist|amod|heart_failure heart_failure|nmod|END_ENTITY	Haemorheological and endothelial-dependent alterations in heart_failure after ACE inhibitor , calcium antagonist and beta blocker .
12586636	0	calcium	66,73	ACE	0,3	calcium	ACE	MESH:D002118	24310(Tax:10116)	Chemical	Gene	mobilization|compound|START_ENTITY mediated|nmod|mobilization mediated|nsubj|END_ENTITY	ACE and non-ACE mediated effect of angiotensin_I on intracellular calcium mobilization in rat glomerular arterioles .
15488653	0	calcium	70,77	ACE	29,32	calcium	ACE	MESH:D002118	1636	Chemical	Gene	supplementation|compound|START_ENTITY utility|nmod|supplementation amplify|dobj|utility amplify|nsubj|treatment treatment|nmod|inhibitor inhibitor|compound|END_ENTITY	Concurrent treatment with an ACE inhibitor may amplify the utility of calcium supplementation for control of hypertension .
2096214	0	calcium	76,83	ACE	120,123	calcium	ACE	MESH:D002118	1636	Chemical	Gene	antagonist|compound|START_ENTITY antagonist|nmod|inhibitor inhibitor|compound|END_ENTITY	Equivalent antihypertensive effects of combination therapy using diuretic + calcium antagonist compared with diuretic + ACE inhibitor .
6258551	9	calcium	1118,1125	ACE	1139,1142	calcium	ACE	MESH:D002118	1636	Chemical	Gene	those|nmod|START_ENTITY half|nmod|those had|nsubj|half had|dobj|END_ENTITY	All sarcoid patients with hypercalcaemia had elevated serum ACE whereas only half of those with normal serum calcium had elevated ACE .
7734098	0	calcium	45,52	ACE	25,28	calcium	ACE	MESH:D002118	24310(Tax:10116)	Chemical	Gene	blockade|compound|START_ENTITY inhibition|nmod|blockade inhibition|nsubj|Comparison Comparison|nmod|effects effects|nmod|END_ENTITY	Comparison of effects of ACE inhibition with calcium channel blockade on renal_disease in a model combining genetic_hypertension and diabetes .
7893583	0	calcium	54,61	ACE	71,74	calcium	ACE	MESH:D002118	1636	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Pharmacokinetics and biochemical efficacy of idrapril calcium , a novel ACE inhibitor , after multiple oral administration in humans .
8208641	0	calcium	22,29	ACE	0,3	calcium	ACE	MESH:D002118	1636	Chemical	Gene	antagonism|compound|START_ENTITY inhibition|nmod|antagonism inhibition|compound|END_ENTITY	ACE inhibition versus calcium antagonism in the treatment of mild to moderate hypertension : a multicentre study .
9101306	0	calcium	33,40	ACE	11,14	calcium	ACE	MESH:D002118	1636	Chemical	Gene	antagonists|compound|START_ENTITY inhibitors|nmod|antagonists inhibitors|nsubj|Effects Effects|nmod|END_ENTITY	Effects of ACE inhibitors versus calcium antagonists on left ventricular morphology and function in patients with essential hypertension .
9111155	0	calcium	44,51	ACE	14,17	calcium	ACE	MESH:D002118	1636	Chemical	Gene	blocker|compound|START_ENTITY combined|nmod|blocker combined|nsubj|Effects Effects|nmod|inhibitor inhibitor|compound|END_ENTITY	Effects of an ACE inhibitor combined with a calcium channel blocker on progression of diabetic_nephropathy .
9267040	0	calcium	88,95	ACE	14,17	calcium	ACE	MESH:D002118	101824864	Chemical	Gene	blocker|compound|START_ENTITY potentiated|nmod|blocker potentiated|nsubjpass|effect effect|nmod|inhibitors inhibitors|compound|END_ENTITY	The effect of ACE inhibitors on atheroma formation is potentiated by association with a calcium channel blocker .
20171208	0	calcium	73,80	AM404	46,51	calcium	AM404	MESH:D002118	3170950(Tax:234826)	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|nmod|channels	The effects of anandamide transport inhibitor AM404 on voltage-dependent calcium channels .
19057515	0	calcium	98,105	AT1_receptor	51,63	calcium	AT1 receptor	MESH:D002118	11610(Tax:10090)	Chemical	Gene	antagonists|compound|START_ENTITY Prevention|nmod|antagonists Prevention|nmod|combination combination|nmod|blocker blocker|amod|END_ENTITY	Prevention of vascular_injury by combination of an AT1_receptor blocker , olmesartan , with various calcium antagonists .
25080489	0	calcium	102,109	AT1_receptor	130,142	calcium	AT1 receptor	MESH:D002118	11610(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY homeostasis|nmod|END_ENTITY	Angiotensin_II modulates mouse skeletal muscle resting conductance to chloride and potassium ions and calcium homeostasis via the AT1_receptor and NADPH oxidase .
10512841	0	calcium	20,27	ATPase	122,128	calcium	ATPase	MESH:D002118	1769	Chemical	Gene	Characterization|nmod|START_ENTITY states|nsubj|Characterization states|nmod|derivatization derivatization|nmod|END_ENTITY	Characterization of calcium , nucleotide , phosphate , and vanadate bound states by derivatization of sarcoplasmic reticulum ATPase with ThioGlo1 .
10562463	0	calcium	43,50	ATPase	90,96	calcium	ATPase	MESH:D002118	1769	Chemical	Gene	mobility|advmod|START_ENTITY activity|amod|mobility activity|amod|END_ENTITY	Phenylarsine_oxide increases intracellular calcium mobility and inhibits Ca -LRB- 2 + -RRB- - dependent ATPase activity in thymocytes .
11976321	0	calcium	24,31	ATPase	48,54	calcium	ATPase	MESH:D002118	1769	Chemical	Gene	regulation|nmod|START_ENTITY regulation|dep|molecules molecules|amod|END_ENTITY	Substrate regulation of calcium binding in Ca2 + - ATPase molecules of the sarcoplasmic reticulum .
124603	0	calcium	83,90	ATPase	48,54	calcium	ATPase	MESH:D002118	1769	Chemical	Gene	presence|nmod|START_ENTITY reaction|nmod|presence reaction|compound|END_ENTITY	-LSB- Study of the stationary kinetics of the myosin ATPase reaction in the presence of calcium -RSB- .
139922	0	calcium	14,21	ATPase	36,42	calcium	ATPase	MESH:D002118	1769	Chemical	Gene	transport|compound|START_ENTITY effect|nmod|transport END_ENTITY|nsubj|effect	The effect of calcium ion transport ATPase upon the passive calcium ion permeability of phospholipid vesicles .
139922	0	calcium	60,67	ATPase	36,42	calcium	ATPase	MESH:D002118	1769	Chemical	Gene	permeability|compound|START_ENTITY END_ENTITY|nmod|permeability	The effect of calcium ion transport ATPase upon the passive calcium ion permeability of phospholipid vesicles .
145515	0	calcium	7,14	ATPase	110,116	calcium	ATPase	MESH:D002118	1769	Chemical	Gene	transport|compound|START_ENTITY transport|dep|END_ENTITY	Active calcium treatment transport via coupling between the enzymatic and the ionophoric sites of Ca2 + + Mg2 + - ATPase .
146715	0	calcium	150,157	ATPase	84,90	calcium	ATPase	MESH:D002118	1769	Chemical	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	Induction by nucleotide_triphosphate hydrolysis of a form of sarcoplasmic reticulum ATPase capable of medium phosphate-oxygen exchange in presence of calcium .
149575	0	calcium	24,31	ATPase	50,56	calcium	ATPase	MESH:D002118	1769	Chemical	Gene	START_ENTITY|nmod|changes changes|nmod|state state|amod|END_ENTITY	-LSB- Role of membrane-bound calcium in changes in the ATPase activity , permeability and structural state of human erythrocyte membranes -RSB- .
15718407	0	calcium	51,58	ATPase	64,70	calcium	ATPase	MESH:D002118	1769	Chemical	Gene	chronic_obstructive_pulmonary_disease|nmod|START_ENTITY Effect|nmod|chronic_obstructive_pulmonary_disease pump|nsubj|Effect pump|dobj|expression expression|amod|END_ENTITY	Effect of chronic_obstructive_pulmonary_disease on calcium pump ATPase expression in human diaphragm .
15885776	0	calcium	81,88	ATPase	22,28	calcium	ATPase	MESH:D002118	1769	Chemical	Gene	response|compound|START_ENTITY contribute|dobj|response contribute|nsubj|activity activity|compound|END_ENTITY	CD_39-associated high ATPase activity contribute to the loss of P 2 X 7-mediated calcium response in LCL cells .
1666413	0	calcium	56,63	ATPase	69,75	calcium	ATPase	MESH:D002118	1769	Chemical	Gene	phospholamban|nmod|START_ENTITY antibody|nmod|phospholamban Effects|nmod|antibody pump|nsubj|Effects pump|dobj|END_ENTITY	Effects of monoclonal antibody against phospholamban on calcium pump ATPase of cardiac sarcoplasmic reticulum .
1824819	0	calcium	12,19	ATPase	98,104	calcium	ATPase	MESH:D002118	1769	Chemical	Gene	Kinetics|nmod|START_ENTITY dissociation|nsubj|Kinetics dissociation|nmod|END_ENTITY	Kinetics of calcium dissociation from its high-affinity transport sites on sarcoplasmic reticulum ATPase .
1835657	0	calcium	8,15	ATPase	179,185	calcium	ATPase	MESH:D002118	1769	Chemical	Gene	ions|compound|START_ENTITY bound|nsubj|ions bound|parataxis|distinguished distinguished|advcl|dissociate dissociate|nmod|END_ENTITY	The two calcium ions initially bound to nonphosphorylated sarcoplasmic reticulum Ca -LRB- 2 + -RRB- - ATPase can no longer be kinetically distinguished when they dissociate from phosphorylated ATPase toward the lumen .
1835657	0	calcium	8,15	ATPase	88,94	calcium	ATPase	MESH:D002118	1769	Chemical	Gene	ions|compound|START_ENTITY bound|nsubj|ions bound|parataxis|distinguished distinguished|nsubj|END_ENTITY	The two calcium ions initially bound to nonphosphorylated sarcoplasmic reticulum Ca -LRB- 2 + -RRB- - ATPase can no longer be kinetically distinguished when they dissociate from phosphorylated ATPase toward the lumen .
183811	0	calcium	50,57	ATPase	29,35	calcium	ATPase	MESH:D002118	1769	Chemical	Gene	protein|compound|START_ENTITY activity|nmod|protein activity|amod|END_ENTITY	Annular lipids determine the ATPase activity of a calcium transport protein complexed with dipalmitoyllecithin .
2138607	0	calcium	52,59	ATPase	108,114	calcium	ATPase	MESH:D002118	1769	Chemical	Gene	mechanism|compound|START_ENTITY mechanism|nmod|END_ENTITY	Effect of diethyl_pyrocarbonate modification on the calcium binding mechanism of the sarcoplasmic reticulum ATPase .
2145042	0	calcium	89,96	ATPase	61,67	calcium	ATPase	MESH:D002118	1769	Chemical	Gene	transport|compound|START_ENTITY appear|nmod|transport appear|nsubj|changes changes|nmod|END_ENTITY	Large-scale structural changes in the sarcoplasmic reticulum ATPase appear essential for calcium transport .
2147565	0	calcium	39,46	ATPase	65,71	calcium	ATPase	MESH:D002118	1769	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|Mg2 Mg2|dep|END_ENTITY	Effects of phospholipids on binding of calcium to -LRB- Ca2 -LRB- + -RRB- - Mg2 -LRB- + -RRB- - ATPase .
21515674	0	calcium	111,118	ATPase	69,75	calcium	ATPase	MESH:D002118	1769	Chemical	Gene	pump|nmod|START_ENTITY pump|nsubj|dependence dependence|nmod|SERCA2a SERCA2a|amod|END_ENTITY	Highly cooperative dependence of sarco/endoplasmic reticulum calcium ATPase SERCA2a pump activity on cytosolic calcium in living cells .
21515674	0	calcium	61,68	ATPase	69,75	calcium	ATPase	MESH:D002118	1769	Chemical	Gene	SERCA2a|compound|START_ENTITY SERCA2a|amod|END_ENTITY	Highly cooperative dependence of sarco/endoplasmic reticulum calcium ATPase SERCA2a pump activity on cytosolic calcium in living cells .
25010036	0	calcium	95,102	ATPase	46,52	calcium	ATPase	MESH:D002118	1769	Chemical	Gene	change|nmod|START_ENTITY faba|dep|change activity|nmod|faba activity|amod|END_ENTITY	Leaf ion homeostasis and plasma membrane H -LRB- + -RRB- - ATPase activity in Vicia faba change after extra calcium and potassium supply under salinity .
2550078	0	calcium	10,17	ATPase	51,57	calcium	ATPase	MESH:D002118	1769	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|molecules molecules|amod|END_ENTITY	Effect of calcium on the interactions between Ca2 + - ATPase molecules in sarcoplasmic reticulum .
2828353	0	calcium	80,87	ATPase	55,61	calcium	ATPase	MESH:D002118	1769	Chemical	Gene	absence|nmod|START_ENTITY END_ENTITY|nmod|absence	Utilization of arylazido-ATP by sarcoplasmic reticulum ATPase in the absence of calcium .
2936732	0	calcium	19,26	ATPase	96,102	calcium	ATPase	MESH:D002118	1769	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|intermediate intermediate|nmod|END_ENTITY	Kinetic effects of calcium and ADP on the phosphorylated intermediate of sarcoplasmic reticulum ATPase .
2942534	0	calcium	20,27	ATPase	116,122	calcium	ATPase	MESH:D002118	1769	Chemical	Gene	release|compound|START_ENTITY influencing|dobj|release influencing|nmod|intermediate intermediate|nmod|END_ENTITY	Factors influencing calcium release from the ADP-sensitive phosphoenzyme intermediate of the sarcoplasmic reticulum ATPase .
2946667	0	calcium	54,61	ATPase	81,87	calcium	ATPase	MESH:D002118	1769	Chemical	Gene	ion-sensitivity|compound|START_ENTITY ion-sensitivity|nmod|END_ENTITY	Effect of chymotryptic troponin_T subfragments on the calcium ion-sensitivity of ATPase and superprecipitation of actomyosin .
2948563	0	calcium	72,79	ATPase	136,142	calcium	ATPase	MESH:D002118	1769	Chemical	Gene	dissociation|nmod|START_ENTITY study|nmod|dissociation filtration|dobj|study filtration|nmod|sites sites|nmod|END_ENTITY	Rapid filtration study of the phosphorylation-dependent dissociation of calcium from transport sites of purified sarcoplasmic reticulum ATPase and ATP modulation of the catalytic cycle .
2954954	0	calcium	72,79	ATPase	15,21	calcium	ATPase	MESH:D002118	1769	Chemical	Gene	activation|compound|START_ENTITY muscle|nmod|activation activity|nmod|muscle activity|amod|END_ENTITY	Changes in the ATPase activity of insect fibrillar flight muscle during calcium and strain activation probed by phosphate-water oxygen exchange .
2959578	0	calcium	54,61	ATPase	70,76	calcium	ATPase	MESH:D002118	1769	Chemical	Gene	requirements|nmod|START_ENTITY requirements|acl|pumping pumping|dobj|END_ENTITY	Ionic and substrate requirements of the high affinity calcium pumping ATPase in endoplasmic reticulum of pancreas .
3158649	0	calcium	62,69	ATPase	134,140	calcium	ATPase	MESH:D002118	1769	Chemical	Gene	transport|compound|START_ENTITY coupled|dobj|transport synthesis|acl|coupled kinetics|nmod|synthesis catalyzed|nsubj|kinetics catalyzed|nmod|END_ENTITY	Steady state kinetics of ATP synthesis and hydrolysis coupled calcium transport catalyzed by the reconstituted sarcoplasmic reticulum ATPase .
4254539	1	calcium	130,137	ATPase	187,193	calcium	ATPase	MESH:D002118	1769	Chemical	Gene	ions|compound|START_ENTITY ions|nmod|reactions reactions|nmod|END_ENTITY	V. Vectorial requirements for calcium and magnesium ions of three partial reactions of ATPase : formation and decomposition of a phosphorylated intermediate and ATP-formation from ADP and the intermediate .
6118990	0	calcium	69,76	ATPase	27,33	calcium	ATPase	MESH:D002118	1769	Chemical	Gene	dependent|nmod|START_ENTITY dependent|dep|END_ENTITY	Regulation of -LRB- Ca2 + , Mg2 + -RRB- - ATPase in human erythrocytes dependent on calcium and calmodulin .
6121798	0	calcium	34,41	ATPase	80,86	calcium	ATPase	MESH:D002118	1769	Chemical	Gene	transport|amod|START_ENTITY regulation|nmod|transport regulation|dep|activity activity|amod|END_ENTITY	Calmodulin-mediated regulation of calcium transport and -LRB- Ca2 + + Mg2 + -RRB- - activated ATPase activity in isolated cardiac sarcoplasmic reticulum .
6213963	0	calcium	35,42	ATPase	81,87	calcium	ATPase	MESH:D002118	1769	Chemical	Gene	cooperative|nmod|START_ENTITY cooperative|nmod|END_ENTITY	Equilibrium cooperative binding of calcium and protons by sarcoplasmic reticulum ATPase .
6450766	0	calcium	91,98	ATPase	23,29	calcium	ATPase	MESH:D002118	1769	Chemical	Gene	gradient|compound|START_ENTITY absence|nmod|gradient phosphate|nmod|absence phosphorylation|nmod|phosphate phosphorylation|nsubj|END_ENTITY	Sarcoplasmic reticulum ATPase phosphorylation from inorganic phosphate in the absence of a calcium gradient .
7983012	0	calcium	30,37	ATPase	83,89	calcium	ATPase	MESH:D002118	1769	Chemical	Gene	types|nmod|START_ENTITY binding|nsubj|types binding|nmod|Ca Ca|dep|END_ENTITY	Two types of proton-modulated calcium binding in the sarcoplasmic reticulum Ca -LRB- 2 + -RRB- - ATPase .
8431438	0	calcium	58,65	ATPase	115,121	calcium	ATPase	MESH:D002118	1769	Chemical	Gene	length|nmod|START_ENTITY functions|dep|length END_ENTITY|dep|functions	Effects of phosphatidylcholine fatty acyl chain length on calcium binding and other functions of the -LRB- Ca -LRB- 2 + -RRB- - Mg2 + -RRB- - ATPase .
8827444	0	calcium	92,99	ATPase	45,51	calcium	ATPase	MESH:D002118	1769	Chemical	Gene	removal|nmod|START_ENTITY reticulum|nmod|removal reticulum|dobj|END_ENTITY	Protection of scallop sarcoplasmic reticulum ATPase from thermal inactivation by removal of calcium from high-affinity binding sites on the enzyme .
16574279	0	calcium	78,85	Abeta	10,15	calcium	Abeta	MESH:D002118	351	Chemical	Gene	channel|compound|START_ENTITY patterns|nmod|channel exposure|nmod|patterns exposure|compound|END_ENTITY	Effect of Abeta exposure on the mRNA expression patterns of voltage-sensitive calcium channel alpha 1 subunits -LRB- alpha 1A-alpha 1D -RRB- in human SK-N-SH_neuroblastoma .
19204293	0	calcium	47,54	Abeta	41,46	calcium	Abeta	MESH:D002118	351	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Small molecule blockers of the Alzheimer Abeta calcium channel potently protect neurons from Abeta cytotoxicity .
19204293	0	calcium	47,54	Abeta	93,98	calcium	Abeta	MESH:D002118	351	Chemical	Gene	channel|compound|START_ENTITY blockers|nmod|channel protect|nsubj|blockers protect|nmod|cytotoxicity cytotoxicity|compound|END_ENTITY	Small molecule blockers of the Alzheimer Abeta calcium channel potently protect neurons from Abeta cytotoxicity .
139159	0	calcium	24,31	Actin	0,5	calcium	Actin	MESH:D002118	176793(Tax:6239)	Chemical	Gene	regulation|compound|START_ENTITY regulation|compound|END_ENTITY	Actin and myosin-linked calcium regulation in the nematode Caenorhabditis_elegans .
1627148	0	calcium	35,42	Activin_A	0,9	calcium	Activin A	MESH:D002118	29200(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY increases|dobj|concentration increases|nsubj|END_ENTITY	Activin_A increases cytosolic free calcium concentration in rat pituitary somatotropes .
21527160	0	calcium	28,35	Adenylyl_cyclase_6	0,18	calcium	Adenylyl cyclase 6	MESH:D002118	11512(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY improves|dobj|uptake improves|nsubj|END_ENTITY	Adenylyl_cyclase_6 improves calcium uptake and left ventricular function in aged hearts .
15968429	0	calcium	37,44	Adrenomedullin	0,14	calcium	Adrenomedullin	MESH:D002118	133	Chemical	Gene	concentration|compound|START_ENTITY reduces|dobj|concentration reduces|nsubj|END_ENTITY	Adrenomedullin reduces intracellular calcium concentration in cultured hippocampal neurons .
8606617	0	calcium	26,33	Adrenomedullin	0,14	calcium	Adrenomedullin	MESH:D002118	280713(Tax:9913)	Chemical	Gene	efflux|compound|START_ENTITY stimulates|dobj|efflux stimulates|nsubj|END_ENTITY	Adrenomedullin stimulates calcium efflux from adrenal chromaffin cells in culture : possible involvement of an Na + / Ca2 + exchange mechanism .
18209483	0	calcium	40,47	Akt/PKB	66,73	calcium	Akt/PKB	MESH:D002118	207	Chemical	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Progesterone potentiates IP -LRB- 3 -RRB- - mediated calcium signaling through Akt/PKB .
8734986	0	calcium	29,36	Albumin	0,7	calcium	Albumin	MESH:D002118	24186(Tax:10116)	Chemical	Gene	uptake|nmod|START_ENTITY stimulates|dobj|uptake stimulates|nsubj|END_ENTITY	Albumin stimulates uptake of calcium into subcellular stores in rat cortical astrocytes .
10444746	0	calcium	37,44	Angiotensin-II	0,14	calcium	Angiotensin-II	MESH:D002118	183	Chemical	Gene	increases|dobj|START_ENTITY increases|nsubj|END_ENTITY	Angiotensin-II increases cytoplasmic calcium , cell number and total DNA for human periodontal ligamental cells in vitro .
2827044	0	calcium	47,54	Angiotensin-converting_enzyme	0,29	calcium	Angiotensin-converting enzyme	MESH:D002118	1636	Chemical	Gene	inhibitor|nmod|START_ENTITY inhibitor|amod|END_ENTITY	Angiotensin-converting_enzyme inhibitor versus calcium antagonist in the treatment of hypertension .
10620186	0	calcium	43,50	Angiotensin_II	0,14	calcium	Angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	activity|compound|START_ENTITY increases|dobj|activity increases|nsubj|END_ENTITY	Angiotensin_II increases the intracellular calcium activity in podocytes of the intact glomerulus .
11545622	0	calcium	103,110	Angiotensin_II	0,14	calcium	Angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY myocytes|nmod|channels release|nmod|myocytes release|nsubj|PGF PGF|compound|END_ENTITY	Angiotensin_II stimulates PGF -LRB- 2 alpha -RRB- release in cultured neonatal rat ventricular myocytes via L-type calcium channels .
12733824	0	calcium	106,113	Angiotensin_II	0,14	calcium	Angiotensin II	MESH:D002118	183	Chemical	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Angiotensin_II and its receptors in human endocardial endothelial cells : role in modulating intracellular calcium .
14615287	0	calcium	71,78	Angiotensin_II	0,14	calcium	Angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY expression|nmod|channels mediate|dobj|expression pathways|xcomp|mediate pathways|nsubj|signaling signaling|compound|END_ENTITY	Angiotensin_II signaling pathways mediate expression of cardiac T-type calcium channels .
14648327	0	calcium	23,30	Angiotensin_II	0,14	calcium	Angiotensin II	MESH:D002118	183	Chemical	Gene	uptake|compound|START_ENTITY reduces|dobj|uptake reduces|nsubj|END_ENTITY	Angiotensin_II reduces calcium uptake into bone .
17289261	0	calcium	90,97	Angiotensin_II	0,14	calcium	Angiotensin II	MESH:D002118	11606(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY mice|nmod|channels amygdala|nmod|mice suppresses|nmod|amygdala suppresses|nsubj|END_ENTITY	Angiotensin_II suppresses long-term depression in the lateral amygdala of mice via L-type calcium channels .
17463319	0	calcium	65,72	Angiotensin_II	0,14	calcium	Angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY subunit|nmod|channel expression|nmod|subunit increases|dobj|expression increases|nsubj|END_ENTITY	Angiotensin_II increases expression of alpha1C subunit of L-type calcium channel through a reactive oxygen species and cAMP response element-binding protein-dependent pathway in HL-1 myocytes .
19141138	0	calcium	101,108	Angiotensin_II	0,14	calcium	Angiotensin II	MESH:D002118	11606(Tax:10090)	Chemical	Gene	increases|nmod|START_ENTITY adenosine|nmod|increases enhances|advcl|adenosine enhances|nsubj|END_ENTITY	Angiotensin_II enhances the afferent arteriolar response to adenosine through increases in cytosolic calcium .
20028346	0	calcium	60,67	Angiotensin_II	0,14	calcium	Angiotensin II	MESH:D002118	183	Chemical	Gene	influx|compound|START_ENTITY regulates|nmod|influx regulates|nsubj|END_ENTITY	Angiotensin_II regulates endothelial cell migration through calcium influx via T-type calcium channel in human umbilical vein endothelial cells .
20028346	0	calcium	86,93	Angiotensin_II	0,14	calcium	Angiotensin II	MESH:D002118	183	Chemical	Gene	channel|compound|START_ENTITY influx|nmod|channel regulates|nmod|influx regulates|nsubj|END_ENTITY	Angiotensin_II regulates endothelial cell migration through calcium influx via T-type calcium channel in human umbilical vein endothelial cells .
21168206	0	calcium	107,114	Angiotensin_II	0,14	calcium	Angiotensin II	MESH:D002118	183	Chemical	Gene	exchanger|compound|START_ENTITY mediated|nmod|exchanger atrial_myocyte_monolayer|acl|mediated electrogram|nmod|atrial_myocyte_monolayer induces|dobj|electrogram induces|nsubj|END_ENTITY	Angiotensin_II induces complex fractionated electrogram in a cultured atrial_myocyte_monolayer mediated by calcium and sodium-calcium exchanger .
21422380	0	calcium	67,74	Angiotensin_II	0,14	calcium	Angiotensin II	MESH:D002118	183	Chemical	Gene	triggers|dobj|START_ENTITY triggers|nsubj|END_ENTITY	Angiotensin_II binding to angiotensin_I-converting_enzyme triggers calcium signaling .
2412702	0	calcium	119,126	Angiotensin_II	0,14	calcium	Angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	fluxes|compound|START_ENTITY analysis|nmod|fluxes pools|dep|analysis mobilizes|nmod|pools mobilizes|nsubj|END_ENTITY	Angiotensin_II and FCCP mobilizes calcium from different intracellular pools in adrenal glomerulosa cells ; analysis of calcium fluxes .
2412702	0	calcium	34,41	Angiotensin_II	0,14	calcium	Angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	mobilizes|dobj|START_ENTITY mobilizes|nsubj|END_ENTITY	Angiotensin_II and FCCP mobilizes calcium from different intracellular pools in adrenal glomerulosa cells ; analysis of calcium fluxes .
24521554	0	calcium	37,44	Angiotensin_II	0,14	calcium	Angiotensin II	MESH:D002118	183	Chemical	Gene	currents|compound|START_ENTITY modulation|nmod|currents induces|dobj|modulation induces|nsubj|END_ENTITY	Angiotensin_II induces modulation of calcium channel currents in osteoblasts .
25172944	0	calcium	39,46	Angiotensin_II	0,14	calcium	Angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	mobilizes|dobj|START_ENTITY mobilizes|nsubj|END_ENTITY	Angiotensin_II mobilizes intracellular calcium and activates pannexin-1 channels in rat carotid body type II cells via AT1 receptors .
2541447	0	calcium	53,60	Angiotensin_II	0,14	calcium	Angiotensin II	MESH:D002118	11606(Tax:10090)	Chemical	Gene	oscillations|nmod|START_ENTITY induces|dobj|oscillations induces|nsubj|END_ENTITY	Angiotensin_II induces oscillations of intracellular calcium and blocks anomalous inward rectifying potassium current in mouse renal juxtaglomerular cells .
4018123	0	calcium	24,31	Angiotensin_II	0,14	calcium	Angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	exchanges|compound|START_ENTITY enhances|dobj|exchanges enhances|nsubj|END_ENTITY	Angiotensin_II enhances calcium exchanges in isolated rat aorta .
7516687	0	calcium	24,31	Angiotensin_II	0,14	calcium	Angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY inhibits|dobj|channels inhibits|nsubj|END_ENTITY	Angiotensin_II inhibits calcium and M current channels in rat sympathetic neurons via G proteins .
7653620	0	calcium	68,75	Angiotensin_II	0,14	calcium	Angiotensin II	MESH:D002118	183	Chemical	Gene	rise|nmod|START_ENTITY mediates|dobj|rise mediates|nsubj|END_ENTITY	Angiotensin_II mediates a sustained rise in nuclear and cytoplasmic calcium via multiple receptor subtypes .
7814036	0	calcium	97,104	Angiotensin_II	0,14	calcium	Angiotensin II	MESH:D002118	183	Chemical	Gene	causes|nmod|START_ENTITY causes|nsubj|binding binding|compound|END_ENTITY	Angiotensin_II binding to human embryonic_lung_fibroblasts causes transient changes in cytosolic calcium and promotes fibrin gel contraction .
7990079	0	calcium	85,92	Angiotensin_II	0,14	calcium	Angiotensin II	MESH:D002118	183	Chemical	Gene	concentrations|compound|START_ENTITY elevated|nmod|concentrations elevated|nsubj|infusions infusions|compound|END_ENTITY	Angiotensin_II infusions elevated blood pressure independently of platelet cytosolic calcium concentrations in humans .
8124662	0	calcium	39,46	Angiotensin_II	0,14	calcium	Angiotensin II	MESH:D002118	183	Chemical	Gene	elevates|dobj|START_ENTITY elevates|nsubj|END_ENTITY	Angiotensin_II elevates cytosolic free calcium in human lung_adenocarcinoma cells via activation of AT1 receptors .
8752105	0	calcium	43,50	Angiotensin_II	0,14	calcium	Angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	Angiotensin_II regulation of intracellular calcium in astroglia cultured from rat hypothalamus and brainstem .
8773772	0	calcium	55,62	Angiotensin_II	19,33	calcium	Angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	currents|compound|START_ENTITY effect|nmod|currents effect|nmod|END_ENTITY	Two-fold effect of Angiotensin_II on voltage-dependent calcium currents in rat retinal_ganglion cells .
9291188	0	calcium	39,46	Angiotensin_II	0,14	calcium	Angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	activity|compound|START_ENTITY increases|dobj|activity increases|nsubj|END_ENTITY	Angiotensin_II increases the cytosolic calcium activity in rat podocytes in culture .
15590065	0	calcium	20,27	Annexin_7	0,9	calcium	Annexin 7	MESH:D002118	11750(Tax:10090)	Chemical	Gene	mobilizes|dobj|START_ENTITY mobilizes|nsubj|END_ENTITY	Annexin_7 mobilizes calcium from endoplasmic reticulum stores in brain .
26073697	0	calcium	33,40	ApoE	11,15	calcium	ApoE	MESH:D002118	11816(Tax:10090)	Chemical	Gene	levels|compound|START_ENTITY Effects|nmod|levels Effects|nmod|END_ENTITY	Effects of ApoE on intracellular calcium levels and apoptosis of neurons after mechanical injury .
3087360	0	calcium	22,29	Apolipoprotein_B	0,16	calcium	Apolipoprotein B	MESH:D002118	338	Chemical	Gene	protein|compound|START_ENTITY protein|nsubj|END_ENTITY	Apolipoprotein_B is a calcium binding protein .
8185566	0	calcium	49,56	Apolipoprotein_E	0,16	calcium	Apolipoprotein E	MESH:D002118	348	Chemical	Gene	affect|dobj|START_ENTITY affect|nsubj|END_ENTITY	Apolipoprotein_E and cholesterol affect neuronal calcium signalling : the possible relationship to beta-amyloid neurotoxicity .
2137191	0	calcium	135,142	Atrial_natriuretic_factor	0,25	calcium	Atrial natriuretic factor	MESH:D002118	4878	Chemical	Gene	load|compound|START_ENTITY effect|nmod|load levels|dep|effect levels|amod|END_ENTITY	Atrial_natriuretic_factor levels in renal_stone patients with idiopathic hypercalciuria and in healthy controls : the effect of an oral calcium load .
2450693	0	calcium	40,47	Atrial_natriuretic_factor	0,25	calcium	Atrial natriuretic factor	MESH:D002118	24602(Tax:10116)	Chemical	Gene	current|compound|START_ENTITY regulates|dobj|current regulates|nsubj|END_ENTITY	Atrial_natriuretic_factor regulates the calcium current in frog isolated cardiac cells .
18081741	0	calcium	24,31	BACE1	42,47	calcium	BACE1	MESH:D002118	23621	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Disrupted intracellular calcium regulates BACE1 gene expression via nuclear_factor_of_activated_T_cells_1 -LRB- NFAT_1 -RRB- signaling .
14625444	0	calcium	60,67	BDNF	26,30	calcium	BDNF	MESH:D002118	12064(Tax:10090)	Chemical	Gene	proteins|compound|START_ENTITY expression|nmod|proteins Differential|nmod|expression Differential|dobj|influence influence|nmod|END_ENTITY	Differential influence of BDNF and NT3 on the expression of calcium binding proteins and neuropeptide Y in vivo .
17898207	0	calcium	76,83	BDNF	26,30	calcium	BDNF	MESH:D002118	627	Chemical	Gene	signaling|compound|START_ENTITY depends|nmod|signaling depends|nsubj|secretion secretion|nmod|END_ENTITY	Postsynaptic secretion of BDNF and NT-3 from hippocampal neurons depends on calcium calmodulin kinase II signaling and proceeds via delayed fusion pore opening .
19923466	7	calcium	1243,1250	BDNF	1278,1282	calcium	BDNF	MESH:D002118	627	Chemical	Gene	entry|compound|START_ENTITY entry|dep|occurred occurred|nmod|application application|amod|END_ENTITY	Sustained activation of store-operated calcium entry occurred after brief BDNF application and contributed to the maintenance of sustained -LSB- Ca -LRB- 2 + -RRB- -RSB- i elevation .
26162542	0	calcium	54,61	BDNF	22,26	calcium	BDNF	MESH:D002118	627	Chemical	Gene	intake|compound|START_ENTITY associated|nmod|intake associated|nsubjpass|variant variant|nmod|END_ENTITY	A common variant near BDNF is associated with dietary calcium intake in adolescents .
9581764	0	calcium	50,57	BDNF	72,76	calcium	BDNF	MESH:D002118	627	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Identification of a signaling pathway involved in calcium regulation of BDNF expression .
1752232	0	calcium	18,25	BGP	35,38	calcium	BGP	MESH:D002118	632	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of dietary calcium on serum BGP -LRB- osteocalcin -RRB- .
7615540	0	calcium	41,48	Basic_fibroblast_growth_factor	0,30	calcium	Basic fibroblast growth factor	MESH:D002118	54250(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY activates|dobj|channels activates|nsubj|END_ENTITY	Basic_fibroblast_growth_factor activates calcium channels in neonatal rat cardiomyocytes .
12022950	0	calcium	11,18	Bcl-2	22,27	calcium	Bcl-2	MESH:D002118	596	Chemical	Gene	role|nmod|START_ENTITY role|nmod|action action|compound|END_ENTITY	A role for calcium in Bcl-2 action ?
23415863	0	calcium	117,124	Bcl-2	22,27	calcium	Bcl-2	MESH:D002118	596	Chemical	Gene	release|compound|START_ENTITY END_ENTITY|nmod|release	Paclitaxel attenuates Bcl-2 resistance to apoptosis in breast_cancer cells through an endoplasmic reticulum-mediated calcium release in a dosage dependent manner .
9419976	0	calcium	34,41	Bcl-2	0,5	calcium	Bcl-2	MESH:D002118	12043(Tax:10090)	Chemical	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	Bcl-2 inhibits c-fos induction by calcium .
9651311	0	calcium	41,48	Bcl-xl	14,20	calcium	Bcl-xl	MESH:D002118	598	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|activity activity|amod|END_ENTITY	Regulation of Bcl-xl channel activity by calcium .
16469868	0	calcium	49,56	Bcr-Abl	0,7	calcium	Bcr-Abl	MESH:D002118	25	Chemical	Gene	levels|compound|START_ENTITY reduces|dobj|levels reduces|nsubj|END_ENTITY	Bcr-Abl reduces endoplasmic reticulum releasable calcium levels by a Bcl-2-independent mechanism and inhibits calcium-dependent apoptotic signaling .
2139666	0	calcium	46,53	Beta-endorphin	0,14	calcium	Beta-endorphin	MESH:D002118	5443	Chemical	Gene	flux|compound|START_ENTITY modulates|dobj|flux modulates|nsubj|END_ENTITY	Beta-endorphin modulates T-cell intracellular calcium flux and c-myc expression via a potassium channel .
8300859	0	calcium	25,32	Beta-endorphin	0,14	calcium	Beta-endorphin	MESH:D002118	5443	Chemical	Gene	activity|compound|START_ENTITY modulates|dobj|activity modulates|nsubj|END_ENTITY	Beta-endorphin modulates calcium channel activity in human neutrophils .
8754765	0	calcium	50,57	Beta-endorphin	0,14	calcium	Beta-endorphin	MESH:D002118	18976(Tax:10090)	Chemical	Gene	mobilization|compound|START_ENTITY enhances|dobj|mobilization enhances|nsubj|END_ENTITY	Beta-endorphin enhances Concanavalin-A-stimulated calcium mobilization by murine splenic_T cells .
11791011	0	calcium	119,126	Bradykinin	0,10	calcium	Bradykinin	MESH:D002118	3827	Chemical	Gene	kinetics|compound|START_ENTITY nitric_oxide|nmod|kinetics inducing|dobj|nitric_oxide inhibits|advcl|inducing inhibits|nsubj|END_ENTITY	Bradykinin inhibits serum-depletion-induced apoptosis of human vascular endothelial cells by inducing nitric_oxide via calcium ion kinetics .
12384249	0	calcium	37,44	Bradykinin	0,10	calcium	Bradykinin	MESH:D002118	3827	Chemical	Gene	increases|nmod|START_ENTITY increases|nsubj|END_ENTITY	Bradykinin increases permeability by calcium and 5-lipoxygenase in the ECV304/C6 cell culture model of the blood-brain barrier .
1333726	0	calcium	42,49	Bradykinin	0,10	calcium	Bradykinin	MESH:D002118	3827	Chemical	Gene	signal|compound|START_ENTITY induces|dobj|signal induces|nsubj|END_ENTITY	Bradykinin induces a B2 receptor-mediated calcium signal linked to prostanoid formation in human gingival fibroblasts in vitro .
1904293	0	calcium	43,50	Bradykinin	0,10	calcium	Bradykinin	MESH:D002118	280833(Tax:9913)	Chemical	Gene	elevations|nmod|START_ENTITY induces|dobj|elevations induces|nsubj|END_ENTITY	Bradykinin induces elevations of cytosolic calcium through mobilisation of intracellular and extracellular pools in bovine aortic endothelial cells .
2742591	0	calcium	81,88	Bradykinin	0,10	calcium	Bradykinin	MESH:D002118	478666(Tax:9615)	Chemical	Gene	changes|nmod|START_ENTITY independent|nmod|changes independent|nsubj|production production|compound|END_ENTITY	Bradykinin stimulated PGE2 production is independent of changes in intracellular calcium in MDCK cells .
2798038	0	calcium	55,62	Bradykinin	0,10	calcium	Bradykinin	MESH:D002118	280833(Tax:9913)	Chemical	Gene	release|compound|START_ENTITY END_ENTITY|dep|release	Bradykinin and inositol_1 ,4,5 - trisphosphate-stimulated calcium release from intracellular stores in cultured bovine endothelial cells .
7686736	0	calcium	108,115	Bradykinin	0,10	calcium	Bradykinin	MESH:D002118	3827	Chemical	Gene	role|nmod|START_ENTITY receptors|dep|role receptors|compound|END_ENTITY	Bradykinin receptors and signal transduction pathways in human fibroblasts : integral role for extracellular calcium .
8077670	0	calcium	71,78	Bradykinin	0,10	calcium	Bradykinin	MESH:D002118	3827	Chemical	Gene	elevation|compound|START_ENTITY stimulus|nmod|elevation stimulus|nsubj|END_ENTITY	Bradykinin is a potent and relatively selective stimulus for cytosolic calcium elevation in human synovial cells .
9657256	0	calcium	35,42	Bradykinin	0,10	calcium	Bradykinin	MESH:D002118	3827	Chemical	Gene	levels|compound|START_ENTITY increases|dobj|levels increases|nsubj|END_ENTITY	Bradykinin increases intracellular calcium levels in a human bronchial epithelial cell line via the B2_receptor subtype .
9719163	0	calcium	40,47	Bradykinin	0,10	calcium	Bradykinin	MESH:D002118	3827	Chemical	Gene	activity|compound|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	Bradykinin stimulates the intracellular calcium activity in human mesothelial cells .
1311010	0	calcium	42,49	C-reactive_protein	0,18	calcium	C-reactive protein	MESH:D002118	100727100	Chemical	Gene	mobilization|compound|START_ENTITY inhibits|dobj|mobilization inhibits|nsubj|END_ENTITY	C-reactive_protein inhibits intracellular calcium mobilization and superoxide production by guinea_pig alveolar macrophages .
15619396	0	calcium	30,37	C-reactive_protein	99,117	calcium	C-reactive protein	MESH:D002118	1401	Chemical	Gene	antagonists|compound|START_ENTITY isosorbide_dinitrate|dep|antagonists Effect|dep|isosorbide_dinitrate Effect|nmod|END_ENTITY	Effect of antispastic agents -LRB- calcium antagonists and/or isosorbide_dinitrate -RRB- on high-sensitivity C-reactive_protein in patients with coronary_vasospastic_angina_pectoris and no hemodynamically significant coronary_artery_disease .
16131811	0	calcium	70,77	C-reactive_protein	0,18	calcium	C-reactive protein	MESH:D002118	1401	Chemical	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	C-reactive_protein induces NF-kappaB activation through intracellular calcium and ROS in human mesangial cells .
20874770	0	calcium	81,88	C-reactive_protein	41,59	calcium	C-reactive protein	MESH:D002118	1401	Chemical	Gene	differences|nmod|START_ENTITY differences|nmod|association association|nmod|END_ENTITY	Gender differences in the association of C-reactive_protein with coronary artery calcium in type-2 diabetes .
21738237	0	calcium	75,82	C-reactive_protein	0,18	calcium	C-reactive protein	MESH:D002118	1401	Chemical	Gene	modifies|nmod|START_ENTITY modifies|nsubj|END_ENTITY	C-reactive_protein modifies the association of plasma leptin with coronary calcium in asymptomatic overweight individuals .
23551080	0	calcium	28,35	C-reactive_protein	0,18	calcium	C-reactive protein	MESH:D002118	1401	Chemical	Gene	triggers|dobj|START_ENTITY triggers|nsubj|END_ENTITY	C-reactive_protein triggers calcium signalling in human neutrophilic granulocytes via FcyRIIa in an allele-specific way .
24508289	0	calcium	87,94	C-reactive_protein	17,35	calcium	C-reactive protein	MESH:D002118	1401	Chemical	Gene	presence|nmod|START_ENTITY associated|nmod|presence associated|nsubjpass|END_ENTITY	High-sensitivity C-reactive_protein is associated with the presence of coronary artery calcium in subjects with normal blood pressure but not in subjects with hypertension .
2692716	0	calcium	68,75	C-reactive_protein	79,97	calcium	C-reactive protein	MESH:D002118	1401	Chemical	Gene	binding|nmod|START_ENTITY involved|nmod|binding involved|nmod|END_ENTITY	Elucidation of a protease-sensitive site involved in the binding of calcium to C-reactive_protein .
6656768	0	calcium	118,125	C-reactive_protein	60,78	calcium	C-reactive protein	MESH:D002118	1401	Chemical	Gene	absence|nmod|START_ENTITY modified|nmod|absence modified|nsubj|alterations alterations|nmod|END_ENTITY	Antigenic , electrophoretic and binding alterations of human C-reactive_protein modified selectively in the absence of calcium .
8119992	0	calcium	11,18	C-reactive_protein	86,104	calcium	C-reactive protein	MESH:D002118	1401	Chemical	Gene	START_ENTITY|nmod|structures structures|nmod|END_ENTITY	Effects of calcium , magnesium , and phosphorylcholine on secondary structures of human C-reactive_protein and serum amyloid P component observed by infrared spectroscopy .
9341775	0	calcium	112,119	C3a	72,75	calcium	C3a	MESH:D002118	718	Chemical	Gene	release|nmod|START_ENTITY END_ENTITY|nmod|release	Blood - and skin-derived monocytes/macrophages respond to C3a but not to C3a -LRB- desArg -RRB- with a transient release of calcium via a pertussis toxin-sensitive signal transduction pathway .
10341236	0	calcium	16,23	CA1	105,108	calcium	CA1	MESH:D002118	759	Chemical	Gene	release|compound|START_ENTITY contributes|nsubj|release contributes|nmod|neurons neurons|compound|END_ENTITY	Calcium-induced calcium release contributes to action potential-evoked calcium transients in hippocampal CA1 pyramidal neurons .
10341236	0	calcium	71,78	CA1	105,108	calcium	CA1	MESH:D002118	759	Chemical	Gene	transients|compound|START_ENTITY contributes|nmod|transients contributes|nmod|neurons neurons|compound|END_ENTITY	Calcium-induced calcium release contributes to action potential-evoked calcium transients in hippocampal CA1 pyramidal neurons .
10482734	0	calcium	15,22	CA1	79,82	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	dependence|compound|START_ENTITY Changes|nmod|dependence Changes|nmod|region region|compound|END_ENTITY	Changes in the calcium dependence of glutamate transmission in the hippocampal CA1 region after brief hypoxia-hypoglycemia .
10516298	0	calcium	10,17	CA1	111,114	calcium	CA1	MESH:D002118	759	Chemical	Gene	initiation|compound|START_ENTITY controlled|nsubjpass|initiation controlled|nmod|neurons neurons|nummod|END_ENTITY	Dendritic calcium spike initiation and repolarization are controlled by distinct potassium channel subtypes in CA1 pyramidal neurons .
10878106	0	calcium	43,50	CA1	89,92	calcium	CA1	MESH:D002118	12346(Tax:10090)	Chemical	Gene	accumulation|compound|START_ENTITY accumulation|nmod|pyramidal_neurones pyramidal_neurones|compound|END_ENTITY	Cholinergic stimulation enhances cytosolic calcium ion accumulation in mouse hippocampal CA1 pyramidal_neurones during short action potential trains .
11113507	0	calcium	22,29	CA1	68,71	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	currents|compound|START_ENTITY currents|acl|maturing maturing|dobj|cells cells|compound|END_ENTITY	Kinetic parameters of calcium currents in maturing acutely isolated CA1 cells .
11306194	0	calcium	100,107	CA1	140,143	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	accumulation|compound|START_ENTITY antagonist|nmod|accumulation effects|nmod|antagonist Characteristics|nmod|effects hippocampal|nsubj|Characteristics hippocampal|dobj|region region|compound|END_ENTITY	Characteristics of protective effects of NMDA antagonist and calcium channel antagonist on ischemic calcium accumulation in rat hippocampal CA1 region .
11588205	0	calcium	64,71	CA1	88,91	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|nmod|neurons neurons|compound|END_ENTITY	Somatic colocalization of rat SK1 and D class -LRB- Ca -LRB- v -RRB- 1.2 -RRB- L-type calcium channels in rat CA1 hippocampal pyramidal neurons .
11677256	0	calcium	28,35	CA1	150,153	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	changes|compound|START_ENTITY Modulation|nmod|changes Modulation|dep|effects effects|nmod|gyrus gyrus|compound|END_ENTITY	Modulation of intracellular calcium changes and glutamate release by neuropeptide Y1 and Y2 receptors in the rat hippocampus : differential effects in CA1 , CA3 and dentate gyrus .
11810440	0	calcium	13,20	CA1	81,84	calcium	CA1	MESH:D002118	759	Chemical	Gene	Detection|nmod|START_ENTITY Detection|nmod|neurons neurons|nmod|region region|compound|END_ENTITY	Detection of calcium and aluminum in pyramidal neurons in the gerbil hippocampal CA1 region following repeated brief_cerebral_ischemia : X-ray microanalysis .
11978822	0	calcium	8,15	CA1	75,78	calcium	CA1	MESH:D002118	759	Chemical	Gene	signaling|compound|START_ENTITY evoked|nsubj|signaling evoked|nmod|neurons neurons|compound|END_ENTITY	Nuclear calcium signaling evoked by cholinergic stimulation in hippocampal CA1 pyramidal neurons .
11997681	0	calcium	36,43	CA1	72,75	calcium	CA1	MESH:D002118	759	Chemical	Gene	START_ENTITY|acl|associated associated|nmod|LTP LTP|compound|END_ENTITY	L-AP3 blocks rises in intracellular calcium associated with hippocampal CA1 LTP .
12163539	0	calcium	27,34	CA1	86,89	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	Extrusion|nmod|START_ENTITY ion|nsubj|Extrusion ion|nmod|region region|compound|END_ENTITY	Extrusion of intracellular calcium ion after in vitro ischemia in the rat hippocampal CA1 region .
12205182	0	calcium	39,46	CA1	88,91	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	mechanisms|compound|START_ENTITY segregation|nmod|mechanisms hippocampal|nsubj|segregation hippocampal|dobj|neurons neurons|nummod|END_ENTITY	Spatial segregation and interaction of calcium signalling mechanisms in rat hippocampal CA1 pyramidal neurons .
12207918	0	calcium	46,53	CA1	66,69	calcium	CA1	MESH:D002118	12346(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY channels|nmod|neurons neurons|nummod|END_ENTITY	Abeta -LRB- 25-35 -RRB- and Abeta -LRB- 1-40 -RRB- act on different calcium channels in CA1 hippocampal neurons .
12270046	0	calcium	68,75	CA1	88,91	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	currents|compound|START_ENTITY currents|nmod|granule granule|compound|END_ENTITY	Differential and long-lasting alterations of high-voltage activated calcium currents in CA1 and dentate granule neurons after status_epilepticus .
12499871	0	calcium	40,47	CA1	76,79	calcium	CA1	MESH:D002118	759	Chemical	Gene	enhancements|compound|START_ENTITY blocks|dobj|enhancements blocks|nmod|area area|compound|END_ENTITY	Thapsigargin blocks STP and LTP related calcium enhancements in hippocampal CA1 area .
12591156	0	calcium	81,88	CA1	130,133	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	alpha1D|compound|START_ENTITY increases|nmod|alpha1D correlated|nmod|increases correlated|nmod|END_ENTITY	Age-related working memory_impairment is correlated with increases in the L-type calcium channel protein alpha1D -LRB- Cav1 .3 -RRB- in area CA1 of the hippocampus and both are ameliorated by chronic nimodipine treatment .
12650963	0	calcium	39,46	CA1	119,122	calcium	CA1	MESH:D002118	759	Chemical	Gene	channels|compound|START_ENTITY Inhibition|nmod|channels causes|nsubj|Inhibition causes|nmod|region region|compound|END_ENTITY	Inhibition of L-type voltage dependent calcium channels causes impairment of long-term potentiation in the hippocampal CA1 region in vivo .
12686387	0	calcium	82,89	CA1	107,110	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	currents|compound|START_ENTITY properties|nmod|currents alterations|nmod|properties alterations|nmod|END_ENTITY	Differential alterations of the inactivation properties of high voltage activated calcium currents in area CA1 and CA3 of the rat following photothrombotic_lesion .
12763626	0	calcium	73,80	CA1	143,146	calcium	CA1	MESH:D002118	759	Chemical	Gene	changes|compound|START_ENTITY D-2_amino-5-phosphonopentanoate|nmod|changes Effect|nmod|D-2_amino-5-phosphonopentanoate associated|nsubj|Effect associated|nmod|potentiation potentiation|nmod|area area|compound|END_ENTITY	Effect of D-2_amino-5-phosphonopentanoate and nifedipine on postsynaptic calcium changes associated with long-term potentiation in hippocampal CA1 area .
12865167	0	calcium	21,28	CA1	74,77	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY hypoxia|nmod|channels Effect|nmod|hypoxia depends|nsubj|Effect depends|nmod|calcium calcium|nmod|neurons neurons|nummod|END_ENTITY	Effect of hypoxia on calcium channels depends on extracellular calcium in CA1 hippocampal neurons .
12865167	0	calcium	63,70	CA1	74,77	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|neurons neurons|nummod|END_ENTITY	Effect of hypoxia on calcium channels depends on extracellular calcium in CA1 hippocampal neurons .
1324252	0	calcium	9,16	CA1	27,30	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	uptake|nsubj|START_ENTITY uptake|nmod|dendrites dendrites|nummod|END_ENTITY	Enhanced calcium uptake by CA1 pyramidal cell dendrites in the postischemic phase despite subnormal evoked field potentials : excitatory amino_acid receptor dependency and relationship to neuronal_damage .
1331856	0	calcium	15,22	CA1	51,54	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	currents|compound|START_ENTITY currents|nmod|neurons neurons|compound|END_ENTITY	Enhancement of calcium currents in rat hippocampal CA1 neurons induced by kindling epileptogenesis .
14517184	0	calcium	25,32	CA1	89,92	calcium	CA1	MESH:D002118	759	Chemical	Gene	transients|compound|START_ENTITY modulates|dobj|transients modulates|nmod|boutons boutons|nmod|neurons neurons|compound|END_ENTITY	Pentobarbitone modulates calcium transients in axons and synaptic boutons of hippocampal CA1 neurons .
14534033	0	calcium	16,23	CA1	45,48	calcium	CA1	MESH:D002118	12346(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY homeostasis|nsubj|effects homeostasis|nmod|neurons neurons|compound|END_ENTITY	Drug effects on calcium homeostasis in mouse CA1 hippocampal neurons .
14736858	0	calcium	24,31	CA1	110,113	calcium	CA1	MESH:D002118	759	Chemical	Gene	waves|compound|START_ENTITY increase|nsubj|waves increase|dobj|frequency frequency|nmod|currents currents|nmod|neurons neurons|nummod|END_ENTITY	Intracellular astrocyte calcium waves in situ increase the frequency of spontaneous AMPA receptor currents in CA1 pyramidal neurons .
15147321	0	calcium	36,43	CA1	135,138	calcium	CA1	MESH:D002118	759	Chemical	Gene	requirement|nmod|START_ENTITY store-operated|nsubj|requirement store-operated|nmod|synapses synapses|compound|END_ENTITY	Frequency-dependent requirement for calcium store-operated mechanisms in induction of homosynaptic long-term depression at hippocampus CA1 synapses .
15211157	0	calcium	29,36	CA1	90,93	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	changes|nmod|START_ENTITY alter|nsubj|changes alter|dobj|firing firing|nmod|cells cells|nummod|END_ENTITY	Small physiologic changes in calcium and magnesium alter excitability and burst firing of CA1 pyramidal cells in rat hippocampal slices .
1525675	0	calcium	29,36	CA1	49,52	calcium	CA1	MESH:D002118	759	Chemical	Gene	currents|compound|START_ENTITY depresses|dobj|currents depresses|nmod|neurons neurons|nummod|END_ENTITY	Interleukin-1_beta depresses calcium currents in CA1 hippocampal neurons at pathophysiological concentrations .
15816941	0	calcium	93,100	CA1	60,63	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY depressing|dobj|channels inhibits|advcl|depressing inhibits|dobj|initiation initiation|nmod|potentials potentials|nmod|neurons neurons|nummod|END_ENTITY	Topiramate inhibits the initiation of plateau potentials in CA1 neurons by depressing R-type calcium channels .
16154266	0	calcium	120,127	CA1	152,155	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|nmod|neurons neurons|compound|END_ENTITY	Mechanism of impairment of long-term potentiation by amyloid beta is independent of NMDA receptors or voltage-dependent calcium channels in hippocampal CA1 pyramidal neurons .
16457957	0	calcium	109,116	CA1	148,151	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	stores|compound|START_ENTITY involved|dobj|stores involved|nmod|END_ENTITY	Lead inhibited N-methyl-D-aspartate receptor-independent long-term potentiation involved ryanodine-sensitive calcium stores in rat hippocampal area CA1 .
1647342	0	calcium	11,18	CA1	94,97	calcium	CA1	MESH:D002118	759	Chemical	Gene	Effects|nmod|START_ENTITY extracellular|nsubj|Effects extracellular|nmod|activity activity|compound|END_ENTITY	Effects of calcium and potassium extracellular ionic concentration changes on the hippocampal CA1 activity of purinergic drugs .
1653853	0	calcium	25,32	CA1	64,67	calcium	CA1	MESH:D002118	100720116	Chemical	Gene	current|compound|START_ENTITY kinetics|nmod|current dissociated|nsubj|kinetics dissociated|dobj|cells cells|nummod|END_ENTITY	Inactivation kinetics of calcium current of acutely dissociated CA1 pyramidal cells of the mature guinea-pig hippocampus .
16763032	0	calcium	33,40	CA1	65,68	calcium	CA1	MESH:D002118	759	Chemical	Gene	currents|compound|START_ENTITY enhancement|nmod|currents enhancement|nmod|pyramidal_neurons pyramidal_neurons|compound|END_ENTITY	Muscarinic enhancement of R-type calcium currents in hippocampal CA1 pyramidal_neurons .
17084819	0	calcium	16,23	CA1	115,118	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY enhances|nsubj|channels enhances|dobj|long-term_depression long-term_depression|acl|induced induced|nmod|synapses synapses|compound|END_ENTITY	Blocking L-type calcium channels enhances long-term_depression induced by low-frequency stimulation at hippocampal CA1 synapses .
1717356	0	calcium	11,18	CA1	82,85	calcium	CA1	MESH:D002118	759	Chemical	Gene	agonist|compound|START_ENTITY Effects|nmod|agonist Effects|nmod|neurons neurons|nummod|END_ENTITY	Effects of calcium channel agonist and antagonists on calcium-dependent events in CA1 hippocampal neurons .
17228340	0	calcium	69,76	CA1	105,108	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	currents|compound|START_ENTITY currents|nmod|neurons neurons|compound|END_ENTITY	Brief RU_38486 treatment normalizes the effects of chronic stress on calcium currents in rat hippocampal CA1 neurons .
17330865	0	calcium	132,139	CA1	102,105	calcium	CA1	MESH:D002118	759	Chemical	Gene	channels|compound|START_ENTITY role|nmod|channels enhances|parataxis|role enhances|nmod|synapses synapses|compound|END_ENTITY	Steroid pregnenolone_sulfate enhances NMDA-receptor-independent long-term potentiation at hippocampal CA1 synapses : role for L-type calcium channels and sigma-receptors .
17562071	0	calcium	93,100	CA1	38,41	calcium	CA1	MESH:D002118	12346(Tax:10090)	Chemical	Gene	release|compound|START_ENTITY hippocampus|nmod|release hippocampus|dobj|neurons neurons|nummod|END_ENTITY	Control of IsAHP in mouse hippocampus CA1 pyramidal neurons by RyR3-mediated calcium-induced calcium release .
17762513	0	calcium	207,214	CA1	35,38	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY role|nmod|channels plasticity|dep|role plasticity|compound|END_ENTITY	Benzodiazepine-induced hippocampal CA1 neuron alpha-amino-3-hydroxy-5-methylisoxasole-4-propionic_acid -LRB- AMPA -RRB- receptor plasticity linked to severity of withdrawal_anxiety : differential role of voltage-gated calcium channels and N-methyl-D-aspartic_acid receptors .
18337367	0	calcium	91,98	CA1	59,62	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY modulating|dobj|channels hippocampus|advcl|modulating hippocampus|dobj|region region|compound|END_ENTITY	Neurotensin enhances GABAergic activity in rat hippocampus CA1 region by modulating L-type calcium channels .
1846413	0	calcium	53,60	CA1	97,100	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY isolated|nsubj|effects isolated|dobj|neurons neurons|compound|END_ENTITY	Calcium antagonist effects on low-threshold -LRB- T-type -RRB- calcium current in rat isolated hippocampal CA1 pyramidal neurons .
18812492	0	calcium	73,80	CA1	105,108	calcium	CA1	MESH:D002118	759	Chemical	Gene	currents|compound|START_ENTITY currents|nmod|neurons neurons|compound|END_ENTITY	Chronic benzodiazepine administration potentiates high voltage-activated calcium currents in hippocampal CA1 neurons .
19215725	0	calcium	138,145	CA1	110,113	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	chelation|compound|START_ENTITY ameliorated|nmod|chelation ameliorated|nsubj|cytosolic cytosolic|nmod|synapses synapses|compound|END_ENTITY	Impaired presynaptic cytosolic and mitochondrial calcium dynamics in aged compared to young adult hippocampal CA1 synapses ameliorated by calcium chelation .
19385055	0	calcium	113,120	CA1	49,52	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY roles|nmod|channel damage|dep|roles damage|compound|END_ENTITY	Isradipine antagonizes hypobaric hypoxia induced CA1 damage and memory_impairment : Complementary roles of L-type calcium channel and NMDA receptors .
19589863	0	calcium	113,120	CA1	37,40	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	protein|compound|START_ENTITY effects|nmod|protein Dissociation|dep|effects Dissociation|nmod|END_ENTITY	Dissociation between rat hippocampal CA1 and dentate gyrus cells in their response to corticosterone : effects on calcium channel protein and current .
1972782	0	calcium	36,43	CA1	72,75	calcium	CA1	MESH:D002118	759	Chemical	Gene	accumulation|compound|START_ENTITY receptor-mediated|dobj|accumulation receptor-mediated|nmod|dendrites dendrites|compound|END_ENTITY	Postsynaptic NMDA receptor-mediated calcium accumulation in hippocampal CA1 pyramidal cell dendrites .
20014384	0	calcium	23,30	CA1	105,108	calcium	CA1	MESH:D002118	12346(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY Deletion|nmod|channel _|nsubj|Deletion _|dep|not not|nmod|neurons neurons|compound|END_ENTITY	Deletion of the L-type calcium channel Ca -LRB- V -RRB- _ 1.3 but not Ca -LRB- V -RRB- _ 1.2 results in a diminished sAHP in mouse CA1 pyramidal neurons .
20128049	0	calcium	38,45	CA1	97,100	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	currents|compound|START_ENTITY currents|acl|induced induced|nmod|peptide peptide|nmod|neurons neurons|nummod|END_ENTITY	Icariin inhibits the increased inward calcium currents induced by amyloid-beta -LRB- 25-35 -RRB- peptide in CA1 pyramidal neurons of neonatal rat hippocampal slice .
20223265	0	calcium	14,21	CA1	85,88	calcium	CA1	MESH:D002118	12346(Tax:10090)	Chemical	Gene	dynamics|compound|START_ENTITY involved|nsubj|dynamics involved|nmod|potentiation potentiation|nmod|neurons neurons|compound|END_ENTITY	Intracellular calcium ion dynamics involved in long-term potentiation in hippocampal CA1 neurons in mice lacking the IP3 type 1 receptor .
2055416	0	calcium	16,23	CA1	76,79	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	antagonists|compound|START_ENTITY changes|compound|antagonists Effects|nmod|changes Effects|nmod|END_ENTITY	Effects of some calcium antagonists and of calcium concentration changes on CA1 paired pulse inhibition in rat hippocampal slices .
20631217	0	calcium	124,131	CA1	29,32	calcium	CA1	MESH:D002118	759	Chemical	Gene	ATPase|compound|START_ENTITY shifts|nmod|ATPase elicit|dobj|shifts elicit|nsubj|potentials potentials|nmod|neurons neurons|nummod|END_ENTITY	Barium plateau potentials of CA1 pyramidal neurons elicit all-or-none extracellular alkaline shifts via the plasma membrane calcium ATPase .
20882545	0	calcium	10,17	CA1	52,55	calcium	CA1	MESH:D002118	759	Chemical	Gene	signals|compound|START_ENTITY signals|nmod|collateral collateral|nmod|synapses synapses|nummod|END_ENTITY	Astrocyte calcium signals at Schaffer collateral to CA1 pyramidal cell synapses correlate with the number of activated synapses but not with synaptic strength .
21103408	0	calcium	131,138	CA1	151,154	calcium	CA1	MESH:D002118	759	Chemical	Gene	channels|compound|START_ENTITY upregulation|nmod|channels mediated|nmod|upregulation mediated|nmod|neurons neurons|nummod|END_ENTITY	A post-burst after depolarization is mediated by group i metabotropic glutamate receptor-dependent upregulation of Ca -LRB- v -RRB- 2.3 R-type calcium channels in CA1 pyramidal neurons .
21123660	0	calcium	112,119	CA1	132,135	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY mediated|nmod|channels mediated|nmod|END_ENTITY	CB1 modulation of temporally distinct synaptic facilitation among local circuit interneurons mediated by N-type calcium channels in CA1 .
21123660	2	calcium	340,347	CA1	421,424	calcium	P18	MESH:D002118	54238(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|acl|used used|nmod|connections connections|nmod|interneurons interneurons|nmod|END_ENTITY	The short-term synaptic plasticity and the subtype of presynaptic calcium channels used at local circuit connections of inhibitory interneurons in CA1 were investigated using dual whole-cell recordings combined with biocytin and double immunofluorescence labeling in acute slices of P18 - to 21-day-old rat stratum radiatum -LRB- SR -RRB- and stratum lacunosum molecular -LRB- SLM -RRB- .
21156150	0	calcium	8,15	CA1	113,116	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	sensors|compound|START_ENTITY reveal|nsubj|sensors reveal|ccomp|boosts boosts|dobj|calcium calcium|acl|signaling signaling|nmod|neurons neurons|nummod|END_ENTITY	Nuclear calcium sensors reveal that repetition of trains of synaptic stimuli boosts nuclear calcium signaling in CA1 pyramidal neurons .
21156150	0	calcium	92,99	CA1	113,116	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	START_ENTITY|acl|signaling signaling|nmod|neurons neurons|nummod|END_ENTITY	Nuclear calcium sensors reveal that repetition of trains of synaptic stimuli boosts nuclear calcium signaling in CA1 pyramidal neurons .
2146781	0	calcium	28,35	CA1	56,59	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	accumulation|compound|START_ENTITY accumulation|nmod|region region|compound|END_ENTITY	Mechanisms of intracellular calcium accumulation in the CA1 region of rat hippocampus during anoxia in vitro .
23357314	0	calcium	15,22	CA1	84,87	calcium	CA1	MESH:D002118	759	Chemical	Gene	proteins|compound|START_ENTITY Differences|nmod|proteins immunoreactivities|nsubj|Differences immunoreactivities|nmod|region region|compound|END_ENTITY	Differences of calcium binding proteins immunoreactivities in the young hippocampal CA1 region from the adult following transient ischemic_damage .
23637181	0	calcium	8,15	CA1	36,39	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|nmod|END_ENTITY	Altered calcium metabolism in aging CA1 hippocampal pyramidal neurons .
24375019	0	calcium	153,160	CA1	35,38	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY influx|nmod|channels requires|dobj|influx requires|nsubj|reduction reduction|nmod|amplitude amplitude|nmod|neurons neurons|nummod|END_ENTITY	The reduction of EPSC amplitude in CA1 pyramidal neurons by the peroxynitrite donor SIN-1 requires Ca2 + influx via postsynaptic non-L-type voltage gated calcium channels .
2446215	0	calcium	45,52	CA1	84,87	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY potentiation|nmod|channel Enhancement|nmod|potentiation agonist|nsubj|Enhancement agonist|dobj|K8644 K8644|nmod|END_ENTITY	Enhancement of long-term potentiation by the calcium channel agonist Bayer K8644 in CA1 of the rat hippocampus in vitro .
24674276	0	calcium	14,21	CA1	128,131	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	elevation|compound|START_ENTITY elevation|nmod|potentials potentials|acl|mediated mediated|nmod|activation activation|nmod|pyramidal_neurons pyramidal_neurons|compound|END_ENTITY	Intracellular calcium elevation during plateau potentials mediated by extrasynaptic NMDA receptor activation in rat hippocampal CA1 pyramidal_neurons is primarily due to calcium entry through voltage-gated calcium channels .
24674276	0	calcium	170,177	CA1	128,131	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	entry|compound|START_ENTITY due|nmod|entry due|nsubj|elevation elevation|nmod|potentials potentials|acl|mediated mediated|nmod|activation activation|nmod|pyramidal_neurons pyramidal_neurons|compound|END_ENTITY	Intracellular calcium elevation during plateau potentials mediated by extrasynaptic NMDA receptor activation in rat hippocampal CA1 pyramidal_neurons is primarily due to calcium entry through voltage-gated calcium channels .
24674276	0	calcium	206,213	CA1	128,131	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY due|nmod|channels due|nsubj|elevation elevation|nmod|potentials potentials|acl|mediated mediated|nmod|activation activation|nmod|pyramidal_neurons pyramidal_neurons|compound|END_ENTITY	Intracellular calcium elevation during plateau potentials mediated by extrasynaptic NMDA receptor activation in rat hippocampal CA1 pyramidal_neurons is primarily due to calcium entry through voltage-gated calcium channels .
2554221	0	calcium	68,75	CA1	12,15	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	conductances|compound|START_ENTITY have|dobj|conductances have|nsubj|cells cells|compound|END_ENTITY	Hippocampal CA1 pyramidal cells of rats have four voltage-dependent calcium conductances .
2559374	0	calcium	27,34	CA1	51,54	calcium	CA1	MESH:D002118	759	Chemical	Gene	content|compound|START_ENTITY content|nmod|END_ENTITY	Elevation of intracellular calcium content in area CA1 of hippocampus is not directly correlated with the development of long-term potentiation .
2713666	0	calcium	19,26	CA1	59,62	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	Reflections|nmod|START_ENTITY epileptiform_activity|nsubj|Reflections epileptiform_activity|nmod|END_ENTITY	Reflections of low calcium epileptiform_activity from area CA1 into dentate gyrus in the rat hippocampal slice .
2795019	0	calcium	17,24	CA1	79,82	calcium	CA1	MESH:D002118	759	Chemical	Gene	blocker|compound|START_ENTITY Effects|nmod|blocker Effects|nmod|cell cell|compound|END_ENTITY	Effects of a new calcium channel blocker , KB-2796 , on protein synthesis of the CA1 pyramidal cell and delayed neuronal_death following transient forebrain_ischemia .
3145928	0	calcium	23,30	CA1	73,76	calcium	CA1	MESH:D002118	100720116	Chemical	Gene	START_ENTITY|nmod|dendrites dendrites|nmod|neurons neurons|compound|END_ENTITY	Increased retention of calcium in the dendrites of long-term potentiated CA1 neurons of the hippocampal slice .
3556495	0	calcium	102,109	CA1	48,51	calcium	CA1	MESH:D002118	759	Chemical	Gene	washout|nmod|START_ENTITY evoked|nmod|washout evoked|dobj|IPSP IPSP|nmod|cells cells|nummod|END_ENTITY	Abolition of the orthodromically evoked IPSP of CA1 pyramidal cells before the EPSP during washout of calcium from hippocampal slices .
6843893	0	calcium	65,72	CA1	106,109	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY free|dobj|concentration free|nmod|END_ENTITY	Aspartate and glutamate induced reductions in extracellular free calcium and sodium concentration in area CA1 of ` in vitro ' hippocampal slices of rats .
6884463	0	calcium	82,89	CA1	37,40	calcium	CA1	MESH:D002118	759	Chemical	Gene	solutions|compound|START_ENTITY neurons|nmod|solutions neurons|nsubj|epileptiform_activity epileptiform_activity|nmod|hippocampal hippocampal|compound|END_ENTITY	Spontaneous epileptiform_activity of CA1 hippocampal neurons in low extracellular calcium solutions .
7623094	0	calcium	30,37	CA1	99,102	calcium	CA1	MESH:D002118	100720116	Chemical	Gene	types|compound|START_ENTITY Block|nmod|types Block|nmod|synapses synapses|amod|omega-conotoxin-MVIIC omega-conotoxin-MVIIC|nmod|END_ENTITY	Block of multiple presynaptic calcium channel types by omega-conotoxin-MVIIC at hippocampal CA3 to CA1 synapses .
7790911	0	calcium	55,62	CA1	97,100	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|neurons neurons|compound|END_ENTITY	Effects of estradiol and progesterone on voltage-gated calcium and potassium conductances in rat CA1 hippocampal neurons .
7823188	0	calcium	23,30	CA1	66,69	calcium	CA1	MESH:D002118	100720116	Chemical	Gene	currents|compound|START_ENTITY currents|acl|guinea_pig guinea_pig|dobj|neurons neurons|compound|END_ENTITY	Cortisol inhibition of calcium currents in guinea_pig hippocampal CA1 neurons via G-protein-coupled activation of protein_kinase_C .
7870309	0	calcium	71,78	CA1	98,101	calcium	CA1	MESH:D002118	100720116	Chemical	Gene	influx|compound|START_ENTITY influx|nmod|cells cells|compound|END_ENTITY	Impairment of GABAA receptor function by N-methyl-D-aspartate-mediated calcium influx in isolated CA1 pyramidal cells .
7953638	0	calcium	48,55	CA1	84,87	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	currents|compound|START_ENTITY modulation|nmod|currents hippocampal|nsubj|modulation hippocampal|dobj|neurons neurons|nummod|END_ENTITY	Corticosteroid receptor-dependent modulation of calcium currents in rat hippocampal CA1 neurons .
8061749	0	calcium	21,28	CA1	69,72	calcium	CA1	MESH:D002118	100009083(Tax:9986)	Chemical	Gene	potentials|compound|START_ENTITY potentials|nmod|neurons neurons|compound|END_ENTITY	Nimodipine decreases calcium action potentials in rabbit hippocampal CA1 neurons in an age-dependent and concentration-dependent manner .
8158251	0	calcium	23,30	CA1	55,58	calcium	CA1	MESH:D002118	100720116	Chemical	Gene	currents|compound|START_ENTITY modulate|dobj|currents modulate|nmod|neurons neurons|compound|END_ENTITY	Neurosteroids modulate calcium currents in hippocampal CA1 neurons via a pertussis toxin-sensitive G-protein-coupled mechanism .
8185949	0	calcium	82,89	CA1	105,108	calcium	CA1	MESH:D002118	759	Chemical	Gene	influx|compound|START_ENTITY reducing|dobj|influx reducing|nmod|END_ENTITY	Adenosine inhibits evoked synaptic transmission primarily by reducing presynaptic calcium influx in area CA1 of hippocampus .
8190261	0	calcium	45,52	CA1	76,79	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	current|compound|START_ENTITY current|nmod|area area|compound|END_ENTITY	Kindling-induced long-lasting enhancement of calcium current in hippocampal CA1 area of the rat : relation to calcium-dependent inactivation .
8229202	0	calcium	14,21	CA1	55,58	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY levels|nmod|region region|compound|END_ENTITY	Intracellular calcium levels and calcium fluxes in the CA1 region of the rat hippocampal slice during in vitro_ischemia : relationship to electrophysiological cell damage .
8390310	0	calcium	24,31	CA1	68,71	calcium	CA1	MESH:D002118	759	Chemical	Gene	currents|compound|START_ENTITY currents|nmod|neurons neurons|compound|END_ENTITY	Interleukin-2 modulates calcium currents in dissociated hippocampal CA1 neurons .
8397354	0	calcium	40,47	CA1	60,63	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	response|compound|START_ENTITY response|nmod|neurons neurons|nummod|END_ENTITY	Bicuculline increases the intracellular calcium response of CA1 hippocampal neurons to synaptic stimulation .
8815908	0	calcium	31,38	CA1	63,66	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	currents|compound|START_ENTITY currents|nmod|neurons neurons|compound|END_ENTITY	Aging changes in voltage-gated calcium currents in hippocampal CA1 neurons .
8890325	0	calcium	30,37	CA1	62,65	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	currents|compound|START_ENTITY currents|nmod|neurons neurons|compound|END_ENTITY	Intracellular QX-314 inhibits calcium currents in hippocampal CA1 pyramidal neurons .
8897834	0	calcium	45,52	CA1	81,84	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY inhibit|dobj|channels inhibit|nmod|neurons neurons|compound|END_ENTITY	TXA2 agonists inhibit high-voltage-activated calcium channels in rat hippocampal CA1 neurons .
8951712	0	calcium	62,69	CA1	93,96	calcium	CA1	MESH:D002118	759	Chemical	Gene	current|compound|START_ENTITY current|nmod|neurones neurones|compound|END_ENTITY	Intracellular inositol_1 ,3,4,5 - tetrakisphosphate enhances the calcium current in hippocampal CA1 neurones of the gerbil after ischaemia .
8981486	0	calcium	14,21	CA1	50,53	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY Inhibition|nmod|channels hippocampal|nsubj|Inhibition hippocampal|dobj|neurons neurons|nummod|END_ENTITY	Inhibition of calcium channels in rat hippocampal CA1 neurons by conantokin-T .
9027871	0	calcium	25,32	CA1	103,106	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	Removal|nmod|START_ENTITY disrupts|nsubj|Removal disrupts|nmod|region region|compound|END_ENTITY	Removal of extracellular calcium after conditioning stimulation disrupts long-term potentiation in the CA1 region of rat hippocampal slices .
9217967	0	calcium	32,39	CA1	87,90	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY Characterisation|nmod|role Characterisation|nmod|potentiation potentiation|nmod|END_ENTITY	Characterisation of the role of calcium in AlF4-induced long-term potentiation in area CA1 of rat hippocampus .
9263588	0	calcium	27,34	CA1	57,60	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	currents|compound|START_ENTITY Development|nmod|currents Development|nmod|neurons neurons|compound|END_ENTITY	Development of HVA and LVA calcium currents in pyramidal CA1 neurons in the hippocampus of the rat .
9356380	0	calcium	14,21	CA1	86,89	calcium	CA1	MESH:D002118	100720116	Chemical	Gene	spikes|compound|START_ENTITY Properties|nmod|spikes revealed|nsubj|Properties revealed|nmod|antagonism antagonism|nmod|neurons neurons|compound|END_ENTITY	Properties of calcium spikes revealed during GABAA receptor antagonism in hippocampal CA1 neurons from guinea_pigs .
9665618	0	calcium	8,15	CA1	41,44	calcium	CA1	MESH:D002118	759	Chemical	Gene	elevation|compound|START_ENTITY elevation|nmod|neurons neurons|compound|END_ENTITY	Reduced calcium elevation in hippocampal CA1 neurons of ischemia-tolerant gerbils .
9729617	0	calcium	14,21	CA1	113,116	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	channel|nsubj|START_ENTITY channel|nmod|cells cells|compound|END_ENTITY	N - and L-type calcium channel involvement in depolarization-induced_suppression_of_inhibition in rat hippocampal CA1 cells .
9774157	0	calcium	31,38	CA1	126,129	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY Inhibition|nmod|channels facilitate|nsubj|Inhibition facilitate|dobj|induction induction|nmod|potentiation potentiation|nmod|region region|compound|END_ENTITY	Inhibition of apamin-sensitive calcium dependent potassium channels facilitate the induction of long-term potentiation in the CA1 region of rat hippocampus in vitro .
9813494	0	calcium	43,50	CA1	79,82	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	adenosine|nmod|START_ENTITY Effect|nmod|adenosine hippocampal|nsubj|Effect hippocampal|dobj|neurons neurons|nummod|END_ENTITY	-LSB- Effect of adenosine on intracellular free calcium in cultured rat hippocampal CA1 neurons during anoxia -RSB- .
9878884	0	calcium	66,73	CA1	86,89	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	currents|compound|START_ENTITY reduce|dobj|currents reduce|nmod|neurones neurones|nummod|END_ENTITY	Protein tyrosine kinase inhibitors reduce high-voltage activating calcium currents in CA1 pyramidal neurones from rat hippocampal slices .
9881856	0	calcium	58,65	CA1	158,161	calcium	CA1	MESH:D002118	100720116	Chemical	Gene	induced|nmod|START_ENTITY induced|nmod|region region|compound|END_ENTITY	Distinct expressions for synaptic potentiation induced by calcium through voltage-gated calcium and N-methyl-D-aspartate receptor channels in the hippocampal CA1 region .
9881856	0	calcium	88,95	CA1	158,161	calcium	CA1	MESH:D002118	100720116	Chemical	Gene	induced|nmod|START_ENTITY induced|nmod|region region|compound|END_ENTITY	Distinct expressions for synaptic potentiation induced by calcium through voltage-gated calcium and N-methyl-D-aspartate receptor channels in the hippocampal CA1 region .
9920654	0	calcium	134,141	CA1	100,103	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	homeostasis|compound|START_ENTITY evidence|nmod|homeostasis neurons|dep|evidence neurons|compound|END_ENTITY	Differential modulation of synaptic transmission by calcium chelators in young and aged hippocampal CA1 neurons : evidence for altered calcium homeostasis in aging .
9920654	0	calcium	52,59	CA1	100,103	calcium	CA1	MESH:D002118	310218(Tax:10116)	Chemical	Gene	transmission|nmod|START_ENTITY modulation|nmod|transmission chelators|nsubj|modulation chelators|nmod|neurons neurons|compound|END_ENTITY	Differential modulation of synaptic transmission by calcium chelators in young and aged hippocampal CA1 neurons : evidence for altered calcium homeostasis in aging .
2203098	0	calcium	15,22	CA3	38,41	calcium	CA3	MESH:D002118	761	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Cytosolic free calcium in hippocampal CA3 pyramidal cells .
7623094	0	calcium	30,37	CA3	92,95	calcium	CA3	MESH:D002118	100306971(Tax:10141)	Chemical	Gene	types|compound|START_ENTITY Block|nmod|types Block|nmod|synapses synapses|amod|omega-conotoxin-MVIIC omega-conotoxin-MVIIC|nmod|END_ENTITY	Block of multiple presynaptic calcium channel types by omega-conotoxin-MVIIC at hippocampal CA3 to CA1 synapses .
8795613	0	calcium	63,70	CA3	94,97	calcium	CA3	MESH:D002118	54232(Tax:10116)	Chemical	Gene	current|compound|START_ENTITY current|nmod|neurons neurons|compound|END_ENTITY	Multiple channel types contribute to the low-voltage-activated calcium current in hippocampal CA3 pyramidal neurons .
9464658	0	calcium	65,72	CA3	101,104	calcium	CA3	MESH:D002118	54232(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|nmod|END_ENTITY	Adenosine A2A receptors facilitate 45Ca2 + uptake through class A calcium channels in rat hippocampal CA3 but not CA1 synaptosomes .
11179022	0	calcium	21,28	CACNA1A	58,65	calcium	CACNA1A	MESH:D002118	773	Chemical	Gene	activity|compound|START_ENTITY activity|acl|caused caused|nmod|mutation mutation|compound|END_ENTITY	Complete loss of P/Q calcium channel activity caused by a CACNA1A missense mutation carried by patients with episodic_ataxia_type_2 .
11409427	0	calcium	83,90	CACNA1A	75,82	calcium	CACNA1A	MESH:D002118	773	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Delayed cerebral_edema and fatal_coma after minor_head_trauma : role of the CACNA1A calcium channel subunit gene and relationship with familial_hemiplegic_migraine .
11701595	0	calcium	62,69	CACNA1A	83,90	calcium	CACNA1A	MESH:D002118	773	Chemical	Gene	channel|compound|START_ENTITY mutations|nmod|channel due|nmod|mutations END_ENTITY|amod|due	Otolith function in cerebellar_ataxia due to mutations in the calcium channel gene CACNA1A .
11843867	0	calcium	22,29	CACNA1A	44,51	calcium	CACNA1A	MESH:D002118	773	Chemical	Gene	gene|compound|START_ENTITY involvement|nmod|gene involvement|appos|END_ENTITY	No involvement of the calcium channel gene -LRB- CACNA1A -RRB- in a family with cluster_headache .
12056940	0	calcium	33,40	CACNA1A	25,32	calcium	CACNA1A	MESH:D002118	773	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Mutation analysis of the CACNA1A calcium channel subunit gene in 27 patients with sporadic_hemiplegic_migraine .
16000334	0	calcium	69,76	CACNA1A	61,68	calcium	CACNA1A	MESH:D002118	773	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Spinocerebellar_ataxia_type_2 : polyQ repeat variation in the CACNA1A calcium channel modifies age of onset .
17376154	0	calcium	101,108	CACNA1A	118,125	calcium	CACNA1A	MESH:D002118	12286(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Forward genetic screen of mouse reveals dominant missense mutation in the P/Q-type voltage-dependent calcium channel , CACNA1A .
20043243	0	calcium	29,36	CACNA1A	91,98	calcium	CACNA1A	MESH:D002118	12286(Tax:10090)	Chemical	Gene	Alterations|nmod|START_ENTITY ion|nsubj|Alterations ion|nmod|cells cells|nmod|mouse mouse|compound|END_ENTITY	Alterations in intracellular calcium ion concentrations in cerebellar granule cells of the CACNA1A mutant mouse , leaner , during postnatal development .
9915947	0	calcium	24,31	CACNA1A	40,47	calcium	CACNA1A	MESH:D002118	773	Chemical	Gene	channel|compound|START_ENTITY Recurrence|nmod|channel END_ENTITY|nsubj|Recurrence	Recurrence of the T666M calcium channel CACNA1A gene mutation in familial_hemiplegic_migraine with progressive_cerebellar_ataxia .
16610939	0	calcium	58,65	CACNA1C	0,7	calcium	CACNA1C	MESH:D002118	775	Chemical	Gene	blockers|compound|START_ENTITY efficacy|nmod|blockers associated|nmod|efficacy associated|nsubjpass|polymorphisms polymorphisms|compound|END_ENTITY	CACNA1C polymorphisms are associated with the efficacy of calcium channel blockers in the treatment of hypertension .
22490625	0	calcium	65,72	CACNA1C	11,18	calcium	CACNA1C	MESH:D002118	775	Chemical	Gene	-RSB-|compound|START_ENTITY efficacy|nmod|-RSB- polymorphisms|nmod|efficacy polymorphisms|nsubj|Impact Impact|nmod|END_ENTITY	-LSB- Impact of CACNA1C polymorphisms on antihypertensive efficacy of calcium channel blocker -RSB- .
23437964	0	calcium	65,72	CACNA1C	82,89	calcium	CACNA1C	MESH:D002118	775	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Suggestive evidence for association between L-type voltage-gated calcium channel -LRB- CACNA1C -RRB- gene haplotypes and bipolar_disorder in Latinos : a family-based association study .
23677916	0	calcium	88,95	CACNA1C	105,112	calcium	CACNA1C	MESH:D002118	775	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Exome sequencing and systems biology converge to identify novel mutations in the L-type calcium channel , CACNA1C , linked to autosomal_dominant_long_QT_syndrome .
10493502	0	calcium	34,41	CACNA1G	16,23	calcium	CACNA1G	MESH:D002118	8913	Chemical	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	Inactivation of CACNA1G , a T-type calcium channel gene , by aberrant methylation of its 5 ' CpG island in human tumors .
12752779	0	calcium	29,36	CACNA1G	51,58	calcium	CACNA1G	MESH:D002118	8913	Chemical	Gene	gene|compound|START_ENTITY Regulation|nmod|gene Regulation|appos|END_ENTITY	Regulation of alpha1G T-type calcium channel gene -LRB- CACNA1G -RRB- expression during neuronal differentiation .
15888660	0	calcium	125,132	CACNA1H	107,114	calcium	CACNA1H	MESH:D002118	8912	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|appos|channel	Functional characterization and neuronal modeling of the effects of childhood_absence_epilepsy variants of CACNA1H , a T-type calcium channel .
16883519	0	calcium	46,53	CACNA1H	15,22	calcium	CACNA1H	MESH:D002118	8912	Chemical	Gene	-RSB-|compound|START_ENTITY mutation|nmod|-RSB- mutation|compound|END_ENTITY	-LSB- The effect of CACNA1H gene G773D mutation on calcium channel function -RSB- .
11260227	0	calcium	88,95	CACNA1S	105,112	calcium	CACNA1S	MESH:D002118	779	Chemical	Gene	channel|compound|START_ENTITY subunit|nmod|channel mutation|nmod|subunit Identification|nmod|mutation Identification|appos|END_ENTITY	Identification of the Arg1086His mutation in the alpha subunit of the voltage-dependent calcium channel -LRB- CACNA1S -RRB- in a North American family with malignant_hyperthermia .
15711422	0	calcium	42,49	CACNA1S	59,66	calcium	CACNA1S	MESH:D002118	779	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Skeletal muscle dihydropyridine-sensitive calcium channel -LRB- CACNA1S -RRB- gene mutations in chinese patients with hypokalemic periodic paralysis .
18588891	0	calcium	19,26	CACNA2D3	49,57	calcium	CACNA2D3	MESH:D002118	55799	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Methylation of the calcium channel-related gene , CACNA2D3 , is frequent and a poor prognostic factor in gastric_cancer .
22644305	0	calcium	19,26	CACNA2D3	62,70	calcium	CACNA2D3	MESH:D002118	55799	Chemical	Gene	-3|compound|START_ENTITY -3|appos|END_ENTITY	Methylation of the calcium channel regulatory subunit a2 -3 -LRB- CACNA2D3 -RRB- predicts site-specific relapse in oestrogen receptor-positive primary breast_carcinomas .
26460247	0	calcium	106,113	CACNA2D3	97,105	calcium	CACNA2D3	MESH:D002118	55799	Chemical	Gene	subunit|compound|START_ENTITY subunit|nummod|END_ENTITY	Genetic contribution to iron status : SNPs related to iron deficiency anaemia and fine mapping of CACNA2D3 calcium channel subunit .
8188298	0	calcium	92,99	CACNL1A3	109,117	calcium	CACNL1A3	MESH:D002118	779	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Refined localization of the alpha 1-subunit of the skeletal muscle L-type voltage-dependent calcium channel -LRB- CACNL1A3 -RRB- to human chromosome 1q32 by in situ hybridization .
8838325	0	calcium	117,124	CACNL1A3	134,142	calcium	CACNL1A3	MESH:D002118	779	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	The structure of the gene encoding the human skeletal muscle alpha 1 subunit of the dihydropyridine-sensitive L-type calcium channel -LRB- CACNL1A3 -RRB- .
8381767	0	calcium	75,82	CACNLB1	92,99	calcium	CACNLB1	MESH:D002118	782	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Assignment of the human gene for the beta subunit of the voltage-dependent calcium channel -LRB- CACNLB1 -RRB- to chromosome 17 using somatic cell hybrids and linkage mapping .
8404045	0	calcium	82,89	CACNLG	104,110	calcium	CACNLG	MESH:D002118	786	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Localization of the gamma-subunit of the skeletal muscle L-type voltage-dependent calcium channel gene -LRB- CACNLG -RRB- to human chromosome band 17q24 by in situ hybridization and identification of a polymorphic repetitive DNA sequence at the gene locus .
19106374	0	calcium	77,84	CASTOR	16,22	calcium	CASTOR	MESH:D002118	100034747(Tax:34305)	Chemical	Gene	essential|nmod|START_ENTITY essential|nsubj|END_ENTITY	Lotus_japonicus CASTOR and POLLUX are ion channels essential for perinuclear calcium spiking in legume root endosymbiosis .
19211808	0	calcium	27,34	CATSPER	62,69	calcium	CATSPER	MESH:D002118	225865(Tax:10090)	Chemical	Gene	entry|compound|START_ENTITY activate|dobj|entry activate|nmod|sperm sperm|nmod|channels channels|amod|END_ENTITY	Egg coat proteins activate calcium entry into mouse sperm via CATSPER channels .
19167228	0	calcium	48,55	CAV2	14,18	calcium	CAV2	MESH:D002118	858	Chemical	Gene	channel|compound|START_ENTITY voltage|dep|channel encodes|dobj|voltage encodes|nsubj|END_ENTITY	Chlamydomonas CAV2 encodes a voltage - dependent calcium channel required for the flagellar waveform conversion .
15322881	0	calcium	64,71	CBL	60,63	calcium	CBL	MESH:D002118	5535	Chemical	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Integration and channeling of calcium signaling through the CBL calcium sensor/CIPK protein kinase network .
9489665	0	calcium	27,34	CBP1	53,57	calcium	CBP1	MESH:D002118	853221(Tax:4932)	Chemical	Gene	acquisition|nmod|START_ENTITY acquisition|nmod|END_ENTITY	Histoplasma acquisition of calcium and expression of CBP1 during intracellular parasitism .
11804848	0	calcium	32,39	CCK	10,13	calcium	CCK	MESH:D002118	25298(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of CCK and intracellular calcium to regulate eIF2B and protein synthesis in rat pancreatic acinar cells .
8134312	0	calcium	8,15	CCK	51,54	calcium	CCK	MESH:D002118	25298(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY END_ENTITY|nsubj|Role	Role of calcium in the bombesin-induced intestinal CCK release in rats .
16196033	0	calcium	162,169	CCL2	154,158	calcium	CCL2	MESH:D002118	24770(Tax:10116)	Chemical	Gene	mobilization|compound|START_ENTITY END_ENTITY|nmod|mobilization	Constitutive neuronal expression of CCR2 chemokine receptor and its colocalization with neurotransmitters in normal rat brain : functional effect of MCP-1 / CCL2 on calcium mobilization in primary cultured neurons .
3438576	0	calcium	17,24	CCL4	129,133	calcium	CCL4	MESH:D002118	116637(Tax:10116)	Chemical	Gene	content|compound|START_ENTITY Changes|nmod|content treated|nsubj|Changes treated|nmod|END_ENTITY	Changes in liver calcium content in relation to serum triiodothyronine -LRB- T3 -RRB- , thyroxine -LRB- T4 -RRB- and T3/T4 ratio in rats treated with CCL4 .
11449371	4	calcium	893,900	CCR3	874,878	calcium	CCR3	MESH:D002118	1232	Chemical	Gene	START_ENTITY|amod|binding binding|nmod|END_ENTITY	Contrary to LD78alpha , LD78beta -LRB- 1 _ - _ 70 -RRB- at 30 ng/ml efficiently competed with -LSB- 125I -RSB- RANTES for binding to CCR3 and mobilized calcium in CCR3 transfectants , whereas LD78beta -LRB- 3 - 70 -RRB- showed a 30-fold decrease in CCR3 affinity compared to LD78beta -LRB- 1 _ - _ 70 -RRB- .
2140358	0	calcium	69,76	CCl4	43,47	calcium	CCl4	MESH:D002118	116637(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY END_ENTITY|nmod|uptake	The in vitro NADPH-dependent inhibition by CCl4 of the ATP-dependent calcium uptake of hepatic microsomes from male rats .
2431691	0	calcium	42,49	CCl4	58,62	calcium	CCl4	MESH:D002118	116637(Tax:10116)	Chemical	Gene	Inhibition|nmod|START_ENTITY pump|nsubj|Inhibition pump|nmod|END_ENTITY	Inhibition of liver endoplasmic reticulum calcium pump by CCl4 and release of a sequestered calcium pool .
2431691	0	calcium	92,99	CCl4	58,62	calcium	CCl4	MESH:D002118	116637(Tax:10116)	Chemical	Gene	pool|compound|START_ENTITY END_ENTITY|nmod|pool	Inhibition of liver endoplasmic reticulum calcium pump by CCl4 and release of a sequestered calcium pool .
6209127	0	calcium	16,23	CCl4	39,43	calcium	CCl4	MESH:D002118	116637(Tax:10116)	Chemical	Gene	Perturbation|nmod|START_ENTITY homeostasis|nsubj|Perturbation homeostasis|nmod|END_ENTITY	Perturbation of calcium homeostasis by CCl4 in rats pretreated with chlordecone and phenobarbital .
2573636	0	calcium	46,53	CD2	24,27	calcium	CD2	MESH:D002118	914	Chemical	Gene	responses|compound|START_ENTITY responses|amod|END_ENTITY	Phorbol esters regulate CD2 - and CD3-mediated calcium responses in peripheral blood-derived human T cells .
14976189	0	calcium	9,16	CD20	4,8	calcium	CD20	MESH:D002118	54474	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	The CD20 calcium channel is localized to microvilli and constitutively associated with membrane rafts : antibody binding increases the affinity of the association through an epitope-dependent cross-linking-independent mechanism .
15730389	0	calcium	91,98	CD20	54,58	calcium	CD20	MESH:D002118	54474	Chemical	Gene	influx|compound|START_ENTITY Rituxan|nmod|influx Rituxan|acl|induced induced|dobj|translocation translocation|nmod|END_ENTITY	Rituxan -LRB- anti-CD20 antibody -RRB- - induced translocation of CD20 into lipid rafts is crucial for calcium influx and apoptosis .
22982241	0	calcium	48,55	CD20	14,18	calcium	CD20	MESH:D002118	54474	Chemical	Gene	modulator|compound|START_ENTITY reveals|dobj|modulator reveals|nsubj|Expression Expression|nmod|END_ENTITY	Expression of CD20 reveals a new store-operated calcium entry modulator in skeletal muscle .
11689885	0	calcium	61,68	CD38	32,36	calcium	CD38	MESH:D002118	952	Chemical	Gene	release|compound|START_ENTITY regulates|dobj|release regulates|nsubj|production production|nmod|END_ENTITY	Cyclic_ADP-ribose production by CD38 regulates intracellular calcium release , extracellular calcium influx and chemotaxis in neutrophils and is required for bacterial clearance in vivo .
15101683	3	calcium	454,461	CD38	439,443	calcium	CD38	MESH:D002118	952	Chemical	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	CD38 regulates calcium signaling in a number of cell types , and it was recently shown that cyclic_ADP-ribose produced by CD38 modulates calcium mobilization induced upon chemokine receptor engagement .
16333382	0	calcium	76,83	CD38	31,35	calcium	CD38	MESH:D002118	952	Chemical	Gene	homeostasis|compound|START_ENTITY mediated|nmod|homeostasis mediated|dobj|changes changes|amod|TNF-alpha-induced TNF-alpha-induced|nmod:npmod|attenuates attenuates|nummod|END_ENTITY	Adenoviral mediated anti-sense CD38 attenuates TNF-alpha-induced changes in calcium homeostasis of human airway smooth muscle cells .
16571778	1	calcium	235,242	CD38	199,203	calcium	CD38	MESH:D002118	952	Chemical	Gene	synthesis|nmod|START_ENTITY catalyzes|dobj|synthesis catalyzes|nsubj|END_ENTITY	The transmembrane glycoprotein CD38 catalyzes the synthesis of the calcium mobilizing molecule cyclic_ADP-ribose from NAD .
17182614	0	calcium	53,60	CD38	98,102	calcium	CD38	MESH:D002118	952	Chemical	Gene	messenger|compound|START_ENTITY basis|nmod|messenger cyclic_ADP-ribose|nsubj|basis cyclic_ADP-ribose|nmod|END_ENTITY	Structural basis for formation and hydrolysis of the calcium messenger cyclic_ADP-ribose by human CD38 .
22142305	0	calcium	34,41	CD38	64,68	calcium	CD38	MESH:D002118	952	Chemical	Gene	inhibitors|nmod|START_ENTITY inhibitors|acl|signaling signaling|dobj|function function|nmod|END_ENTITY	Catalysis-based inhibitors of the calcium signaling function of CD38 .
23940051	0	calcium	144,151	CD38	31,35	calcium	CD38	MESH:D002118	12494(Tax:10090)	Chemical	Gene	release|compound|START_ENTITY mediates|nmod|release mediates|nsubj|Cluster Cluster|appos|END_ENTITY	Cluster of differentiation 38 -LRB- CD38 -RRB- mediates bile_acid-induced acinar_cell_injury and pancreatitis through cyclic_ADP-ribose and intracellular calcium release .
9525901	0	calcium	43,50	CD38	14,18	calcium	CD38	MESH:D002118	952	Chemical	Gene	concentration|compound|START_ENTITY intracellular|dobj|concentration intracellular|nsubj|Expression Expression|nmod|increases increases|nummod|END_ENTITY	Expression of CD38 increases intracellular calcium concentration and reduces doubling time in HeLa and 3T3 cells .
11576220	0	calcium	73,80	CD4	103,106	calcium	CD4	MESH:D002118	920	Chemical	Gene	START_ENTITY|acl|signalling signalling|nmod|cells cells|compound|END_ENTITY	Schiff_base-mediated co-stimulation primes the T-cell-receptor-dependent calcium signalling pathway in CD4 T cells .
8101719	0	calcium	30,37	CD4	41,44	calcium	CD4	MESH:D002118	920	Chemical	Gene	START_ENTITY|nmod|cells cells|nummod|END_ENTITY	Blunted rise in intracellular calcium in CD4 + T cells in response to mitogen following autologous bone marrow transplantation .
22809761	0	calcium	29,36	CFTR	74,78	calcium	CFTR	MESH:D002118	1080	Chemical	Gene	signaling|compound|START_ENTITY signaling|nmod|END_ENTITY	P. _ aeruginosa LPS stimulates calcium signaling and chloride secretion via CFTR in human bronchial epithelial cells .
7517672	0	calcium	40,47	CFTR	26,30	calcium	CFTR	MESH:D002118	1080	Chemical	Gene	proteins|compound|START_ENTITY proteins|compound|END_ENTITY	Increased coexpression of CFTR and S100 calcium binding proteins MRP8 and MRP14 mRNAs in cystic_fibrosis human tracheal gland cells .
18762885	0	calcium	12,19	CGRP	85,89	calcium	CGRP	MESH:D002118	24241(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of calcium in endotoxin-induced release of calcitonin_gene-related_peptide -LRB- CGRP -RRB- from rat spinal cord .
21454501	0	calcium	77,84	CHERP	128,133	calcium	CHERP	MESH:D002118	10523	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Identification of novel ryanodine receptor 1 -LRB- RyR1 -RRB- protein interaction with calcium homeostasis endoplasmic reticulum protein -LRB- CHERP -RRB- .
23148228	0	calcium	99,106	CHERP	80,85	calcium	CHERP	MESH:D002118	10523	Chemical	Gene	signaling|compound|START_ENTITY Re-evaluation|nmod|signaling Re-evaluation|appos|END_ENTITY	Re-evaluation of the role of calcium_homeostasis_endoplasmic_reticulum_protein -LRB- CHERP -RRB- in cellular calcium signaling .
15325243	0	calcium	14,21	COX-2	30,35	calcium	COX-2	MESH:D002118	19225(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Extracellular calcium induces COX-2 in osteoblasts via a PKA pathway .
17352658	0	calcium	47,54	COX-2	14,19	calcium	COX-2	MESH:D002118	17709(Tax:10090)	Chemical	Gene	efflux|compound|START_ENTITY mediates|dobj|efflux mediates|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of COX-2 mediates acid-induced bone calcium efflux in vitro .
20452970	0	calcium	106,113	COX-2	189,194	calcium	COX-2	MESH:D002118	5743	Chemical	Gene	remodeling|nmod|START_ENTITY expression|acl|remodeling increases|dobj|expression increases|parataxis|prostacyclin prostacyclin|nsubj|role role|nmod|A A|dep|cyclooxygenase-2 cyclooxygenase-2|appos|END_ENTITY	Endothelin-1 -LRB- ET-1 -RRB- increases the expression of remodeling genes in vascular smooth muscle through linked calcium and cAMP pathways : role of a phospholipase A -LRB- 2 -RRB- -LRB- cPLA -LRB- 2 -RRB- -RRB- / cyclooxygenase-2 -LRB- COX-2 -RRB- / prostacyclin receptor-dependent autocrine loop .
21924350	0	calcium	30,37	COX-2	64,69	calcium	COX-2	MESH:D002118	5743	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|acl|signaling signaling|nmod|activation activation|compound|END_ENTITY	Involvement of store-operated calcium signaling in EGF-mediated COX-2 gene activation in cancer cells .
10900019	0	calcium	60,67	CREB	85,89	calcium	CREB	MESH:D002118	1385	Chemical	Gene	influx|compound|START_ENTITY synthase|nmod|influx synthase|nmod|mechanism mechanism|compound|END_ENTITY	Dynamic regulation of neuronal NO synthase transcription by calcium influx through a CREB family transcription factor-dependent mechanism .
12773552	0	calcium	18,25	CREB	138,142	calcium	CREB	MESH:D002118	1385	Chemical	Gene	Synergism|nmod|START_ENTITY requires|nsubj|Synergism requires|dobj|cooperation cooperation|nmod|END_ENTITY	Synergism between calcium and cyclic_GMP in cyclic_AMP response element-dependent transcriptional regulation requires cooperation between CREB and C/EBP-beta .
15454081	0	calcium	42,49	CREB	4,8	calcium	CREB	MESH:D002118	1385	Chemical	Gene	detector|amod|START_ENTITY functions|nmod|detector coactivator|dobj|functions coactivator|nsubj|END_ENTITY	The CREB coactivator TORC2 functions as a calcium - and cAMP-sensitive coincidence detector .
16631827	0	calcium	7,14	CREB	67,71	calcium	CREB	MESH:D002118	81646(Tax:10116)	Chemical	Gene	ligands|compound|START_ENTITY block|nsubj|ligands block|xcomp|nicotine-induced nicotine-induced|dep|signaling signaling|nmod|END_ENTITY	L-type calcium channel ligands block nicotine-induced signaling to CREB by inhibiting nicotinic receptors .
20600930	0	calcium	36,43	CREB	134,138	calcium	CREB	MESH:D002118	81646(Tax:10116)	Chemical	Gene	influx|compound|START_ENTITY inhibit|dobj|influx inhibit|advcl|developing developing|nmod|effects effects|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Conantokins inhibit NMDAR-dependent calcium influx in developing rat hippocampal neurons in primary culture with resulting effects on CREB phosphorylation .
25154887	0	calcium	15,22	CREB	0,4	calcium	CREB	MESH:D002118	1385	Chemical	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	CREB modulates calcium signaling in cAMP-induced bone marrow stromal cells -LRB- BMSCs -RRB- .
18304485	0	calcium	16,23	CRF	0,3	calcium	CRF	MESH:D002118	1392	Chemical	Gene	release|compound|START_ENTITY facilitates|dobj|release facilitates|nsubj|END_ENTITY	CRF facilitates calcium release from intracellular stores in midbrain dopamine neurons .
8047294	0	calcium	63,70	CRF	126,129	calcium	CRF	MESH:D002118	81648(Tax:10116)	Chemical	Gene	dependence|compound|START_ENTITY dependence|nmod|END_ENTITY	In vivo microdialysis of corticotropin_releasing_factor -LRB- CRF -RRB- : calcium dependence of depolarization-induced neurosecretion of CRF .
24049670	0	calcium	12,19	CXCL8	57,62	calcium	CXCL8	MESH:D002118	3576	Chemical	Gene	role|nmod|START_ENTITY role|nmod|regulation regulation|nmod|expression expression|compound|END_ENTITY	The role of calcium , NF-kB and NFAT in the regulation of CXCL8 and IL-6 expression in Jurkat T-cells .
17119953	0	calcium	13,20	CXCR1	59,64	calcium	CXCR1	MESH:D002118	281863(Tax:9913)	Chemical	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Differential calcium signaling in dairy cows with specific CXCR1 genotypes potentially related to interleukin-8_receptor functionality .
19220581	0	calcium	14,21	CXCR4	32,37	calcium	CXCR4	MESH:D002118	12767(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Extracellular calcium increases CXCR4 expression on bone marrow-derived cells and enhances pro-angiogenesis therapy .
20236619	0	calcium	60,67	CYP27B1	5,12	calcium	CYP27B1	MESH:D002118	114700(Tax:10116)	Chemical	Gene	increased|nmod|START_ENTITY increased|nsubjpass|expression expression|compound|END_ENTITY	Bone CYP27B1 gene expression is increased with high dietary calcium and in mineralising osteoblasts .
1351266	0	calcium	37,44	Ca1	101,104	calcium	Ca1	MESH:D002118	100720116	Chemical	Gene	influx|compound|START_ENTITY modification|nmod|influx modification|nmod|neurons neurons|amod|END_ENTITY	Persisting modification of dendritic calcium influx by excitatory amino_acid stimulation in isolated Ca1 neurons .
11312263	0	calcium	53,60	Ca2	121,124	calcium	Ca2	MESH:D002118	54231(Tax:10116)	Chemical	Gene	protein|amod|START_ENTITY target|nmod|protein target|parataxis|homeostasis homeostasis|nsubj|implications implications|nmod|+ +|amod|END_ENTITY	The giant protein AHNAK is a specific target for the calcium - and zinc-binding S100B protein : potential implications for Ca2 + homeostasis regulation by S100B .
11739583	0	calcium	41,48	Ca2	23,26	calcium	Ca2	MESH:D002118	54231(Tax:10116)	Chemical	Gene	activity|compound|START_ENTITY +|dobj|activity +|nsubj|END_ENTITY	Elevated postsynaptic -LSB- Ca2 + -RSB- i and L-type calcium channel activity in aged hippocampal neurons : relationship to impaired synaptic plasticity .
11836243	0	calcium	49,56	Ca2	120,123	calcium	Ca2	MESH:D002118	760	Chemical	Gene	proteins|compound|START_ENTITY groups|nmod|proteins use|nmod|groups use|nmod|determinant determinant|nmod|aspects aspects|nmod|transduction transduction|amod|END_ENTITY	Differential use of myristoyl groups on neuronal calcium sensor proteins as a determinant of spatio-temporal aspects of Ca2 + signal transduction .
12148843	0	calcium	49,56	Ca2	17,20	calcium	Ca2	MESH:D002118	54231(Tax:10116)	Chemical	Gene	stores|compound|START_ENTITY +|nmod|stores +|nsubj|END_ENTITY	Swelling-induced Ca2 + release from intracellular calcium stores in rat submandibular gland acinar cells .
12535760	1	calcium	126,133	Ca2	182,185	calcium	Ca2	MESH:D002118	760	Chemical	Gene	START_ENTITY|nmod|lumen lumen|nmod|reticulum reticulum|appos|L L|compound|END_ENTITY	The concentration of free calcium within the lumen of the endoplasmic reticulum -LRB- -LSB- Ca2 + -RSB- L -RRB- fluctuates between 100 and 1000 microM .
15572354	0	calcium	117,124	Ca2	56,59	calcium	Ca2	MESH:D002118	760	Chemical	Gene	overexpressing|dobj|START_ENTITY cells|acl|overexpressing stores|nmod|cells modulates|nmod|stores modulates|dobj|release release|nmod|+ +|amod|END_ENTITY	Protein_kinase_C modulates agonist-sensitive release of Ca2 + from internal stores in HEK293 cells overexpressing the calcium sensing receptor .
1577167	0	calcium	97,104	Ca2	164,167	calcium	Ca2	MESH:D002118	760	Chemical	Gene	pools|compound|START_ENTITY pools|nmod|reduction reduction|nmod|concentration concentration|compound|END_ENTITY	Do submaximal InsP3 concentrations only induce the partial discharge of permeabilized hepatocyte calcium pools because of the concomitant reduction of intraluminal Ca2 + concentration ?
15797246	0	calcium	153,160	Ca2	30,33	calcium	Ca2	MESH:D002118	760	Chemical	Gene	channel|compound|START_ENTITY stores|nmod|channel +|nmod|stores +|nsubj|END_ENTITY	Ceramide increase cytoplasmic Ca2 + concentration in Jurkat T cells by liberation of calcium from intracellular stores and activation of a store-operated calcium channel .
15797246	0	calcium	84,91	Ca2	30,33	calcium	Ca2	MESH:D002118	760	Chemical	Gene	liberation|nmod|START_ENTITY +|nmod|liberation +|nsubj|END_ENTITY	Ceramide increase cytoplasmic Ca2 + concentration in Jurkat T cells by liberation of calcium from intracellular stores and activation of a store-operated calcium channel .
1742874	0	calcium	26,33	Ca2	86,89	calcium	Ca2	MESH:D002118	100719293	Chemical	Gene	affect|dobj|START_ENTITY affect|advcl|guinea_pig guinea_pig|dobj|myocytes myocytes|acl:relcl|buffered buffered|nsubjpass|+ +|compound|END_ENTITY	Ryanodine does not affect calcium current in guinea_pig ventricular myocytes in which Ca2 + is buffered .
18371074	0	calcium	45,52	Ca2	54,57	calcium	Ca2	MESH:D002118	54231(Tax:10116)	Chemical	Gene	START_ENTITY|appos|+ +|compound|END_ENTITY	Traumatic_brain_injury causes a long-lasting calcium -LRB- Ca2 + -RRB- - plateau of elevated intracellular Ca levels and altered Ca2 + homeostatic mechanisms in hippocampal neurons surviving brain_injury .
1898654	0	calcium	84,91	Ca2	0,3	calcium	Ca2	MESH:D002118	760	Chemical	Gene	precipitate|compound|START_ENTITY formation|nmod|precipitate due|nmod|formation cells|acl:relcl|due thrombospondin|nmod|cells sensitive|nmod|thrombospondin END_ENTITY|dep|sensitive	Ca2 -LRB- + -RRB- - sensitive binding of thrombospondin to U937 cells is due to the formation of calcium precipitate in the binding medium .
19075015	0	calcium	57,64	Ca2	83,86	calcium	Ca2	MESH:D002118	760	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	The Orai1 severe_combined_immune_deficiency mutation and calcium release-activated Ca2 + channel function in the heterozygous condition .
2004606	1	calcium	158,165	Ca2	167,170	calcium	PTH	MESH:D002118	280903(Tax:9913)	Chemical	Gene	START_ENTITY|appos|+ +|compound|END_ENTITY	The suppression of PTH release by high extracellular calcium -LRB- Ca2 + -RRB- has been associated with secretion of biologically inactive carboxyl-terminal fragments of PTH -LRB- C-PTH -RRB- , while relatively more intact PTH is released under low extracellular Ca2 + conditions .
20550942	0	calcium	14,21	Ca2	141,144	calcium	Ca2	MESH:D002118	54231(Tax:10116)	Chemical	Gene	depletion|compound|START_ENTITY elevates|nsubj|depletion elevates|nmod|activation activation|nmod|exchange exchange|compound|END_ENTITY	Extracellular calcium depletion transiently elevates oxygen consumption in neurosecretory PC12 cells through activation of mitochondrial Na + / Ca2 + exchange .
2160308	0	calcium	106,113	Ca2	46,49	calcium	Ca2	MESH:D002118	760	Chemical	Gene	overload|compound|START_ENTITY induced|nmod|overload induced|nmod|ions ions|amod|END_ENTITY	-LSB- The role of Na -LRB- + -RRB- pump inhibition induced by Ca2 -LRB- + -RRB- ions in the development of pathologic changes during calcium overload in myocardial cells -RSB- .
24270805	0	calcium	57,64	Ca2	21,24	calcium	Ca2	MESH:D002118	760	Chemical	Gene	channel|compound|START_ENTITY selectivity|nmod|channel +|dobj|selectivity +|nsubj|basis basis|nmod|END_ENTITY	Structural basis for Ca2 + selectivity of a voltage-gated calcium channel .
24375019	0	calcium	153,160	Ca2	99,102	calcium	Ca2	MESH:D002118	54231(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY influx|nmod|channels influx|amod|END_ENTITY	The reduction of EPSC amplitude in CA1 pyramidal neurons by the peroxynitrite donor SIN-1 requires Ca2 + influx via postsynaptic non-L-type voltage gated calcium channels .
2532882	2	calcium	193,200	Ca2	266,269	calcium	Ca2	MESH:D002118	760	Chemical	Gene	concentration|nmod|START_ENTITY measured|nsubjpass|concentration measured|xcomp|using using|xcomp|indo-1 indo-1|nsubj|indicator indicator|amod|END_ENTITY	The concentration of cytoplasmic ionized calcium , -LSB- Ca2 + -RSB- i , was measured in monolayers of fused myotubes using the Ca2 + indicator indo-1 .
7081424	0	calcium	19,26	Ca2	0,3	calcium	Ca2	MESH:D002118	54231(Tax:10116)	Chemical	Gene	dependence|nmod|START_ENTITY dependence|amod|END_ENTITY	Ca2 + dependence of calcium uptake by rat myometrium plasma membrane-enriched fraction .
8394428	0	calcium	18,25	Ca2	49,52	calcium	Ca2	MESH:D002118	760	Chemical	Gene	Inhibition|nmod|START_ENTITY pump|nsubj|Inhibition pump|nmod|+ +|amod|END_ENTITY	Inhibition of the calcium pump by high cytosolic Ca2 + in intact human red blood cells .
9037541	0	calcium	102,109	Ca2	111,114	calcium	Ca2	MESH:D002118	54231(Tax:10116)	Chemical	Gene	protein|appos|START_ENTITY protein|appos|+ +|compound|END_ENTITY	Cloning and expression localization of cDNA for rat homolog of TRP protein , a possible store-operated calcium -LRB- Ca2 + -RRB- channel .
9330787	7	calcium	1141,1148	Ca2	1102,1105	calcium	Ca2	MESH:D002118	379772(Tax:8355)	Chemical	Gene	removal|nmod|START_ENTITY was|nsubj|removal was|nmod|step step|amod|END_ENTITY	Following each Ca2 + step , there was a slow removal of calcium before the next step boosted the overall level of Ca2 + .
3141012	0	calcium	27,34	CaBP	58,62	calcium	CaBP	MESH:D002118	795	Chemical	Gene	transport|compound|START_ENTITY transport|dep|role role|nmod|END_ENTITY	Vitamin_D-dependent active calcium transport : the role of CaBP .
21383011	0	calcium	83,90	CaBP1	0,5	calcium	CaBP1	MESH:D002118	9478	Chemical	Gene	channels|compound|START_ENTITY 1.2|dep|channels voltage-dependent_inactivation|nmod|1.2 regulates|dobj|voltage-dependent_inactivation regulates|nsubj|END_ENTITY	CaBP1 regulates voltage-dependent_inactivation and activation of Ca -LRB- V -RRB- 1.2 -LRB- L-type -RRB- calcium channels .
7876340	0	calcium	9,16	CaBP1	0,5	calcium	CaBP1	MESH:D002118	171051(Tax:10116)	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	CaBP1 , a calcium binding protein of the thioredoxin family , is a resident KDEL protein of the ER and not of the intermediate compartment .
23284721	0	calcium	36,43	CaCDPK1	72,79	calcium	CaCDPK1	MESH:D002118	101500581	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Phospholipid mediated activation of calcium dependent protein kinase 1 -LRB- CaCDPK1 -RRB- from chickpea : a new paradigm of regulation .
25855000	0	calcium	30,37	CaCDPK1	66,73	calcium	CaCDPK1	MESH:D002118	101500581	Chemical	Gene	protein|compound|START_ENTITY properties|nmod|protein kinase|nsubj|properties kinase|dobj|1 1|appos|END_ENTITY	Calcium binding properties of calcium dependent protein kinase 1 -LRB- CaCDPK1 -RRB- from Cicer_arietinum .
1708204	0	calcium	55,62	CaMKII	0,6	calcium	CaMKII	MESH:D002118	818	Chemical	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	CaMKII mediates stimulation of chloride conductance by calcium in T84 cells .
17119905	0	calcium	41,48	CaMKII	0,6	calcium	CaMKII	MESH:D002118	818	Chemical	Gene	homeostasis|compound|START_ENTITY driver|nmod|homeostasis END_ENTITY|appos|driver	CaMKII , an emerging molecular driver for calcium homeostasis , arrhythmias , and cardiac_dysfunction .
18639555	0	calcium	37,44	CaMKII	18,24	calcium	CaMKII	MESH:D002118	818	Chemical	Gene	homeostasis|compound|START_ENTITY END_ENTITY|nmod|homeostasis	Role of activated CaMKII in abnormal calcium homeostasis and I -LRB- Na -RRB- remodeling after myocardial_infarction : insights from mathematical modeling .
19840220	0	calcium	37,44	CaMKII	0,6	calcium	CaMKII	MESH:D002118	818	Chemical	Gene	channels|compound|START_ENTITY associates|nmod|channels associates|compound|END_ENTITY	CaMKII associates with CaV1 .2 L-type calcium channels via selected beta subunits to enhance regulatory phosphorylation .
20538682	0	calcium	22,29	CaMKII	62,68	calcium	CaMKII	MESH:D002118	108058(Tax:10090)	Chemical	Gene	current|amod|START_ENTITY Alterations|nmod|current Alterations|nmod|delta delta|compound|END_ENTITY	Alterations of L-type calcium current and cardiac function in CaMKII -LCB- delta -RCB- knockout mice .
23657616	0	calcium	52,59	CaMKII	72,78	calcium	CaMKII	MESH:D002118	818	Chemical	Gene	channels|compound|START_ENTITY channels|nmod|CK59 CK59|compound|END_ENTITY	Nonspecific , reversible inhibition of voltage-gated calcium channels by CaMKII inhibitor CK59 .
24062638	0	calcium	62,69	CaMKII	15,21	calcium	CaMKII	MESH:D002118	43828(Tax:7227)	Chemical	Gene	growth|appos|START_ENTITY autophosphorylation|nmod|growth autophosphorylation|compound|END_ENTITY	CASK regulates CaMKII autophosphorylation in neuronal growth , calcium signaling , and learning .
24498331	0	calcium	87,94	CaMKII	37,43	calcium	CaMKII	MESH:D002118	12323(Tax:10090)	Chemical	Gene	release|compound|START_ENTITY increases|dobj|release increases|nsubj|activation activation|nmod|END_ENTITY	Nitric_oxide-dependent activation of CaMKII increases diastolic sarcoplasmic reticulum calcium release in cardiac myocytes in response to adrenergic stimulation .
26255006	0	calcium	48,55	CaMKII	13,19	calcium	CaMKII	MESH:D002118	12325(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY regulation|nmod|channels regulation|nsubj|END_ENTITY	Differential CaMKII regulation by voltage-gated calcium channels in the striatum .
10907347	0	calcium	57,64	CaR	19,22	calcium	CaR	MESH:D002118	846	Chemical	Gene	homeostasis|compound|START_ENTITY regulation|nmod|homeostasis approach|nmod|regulation Calcium_receptor|dep|approach Calcium_receptor|appos|END_ENTITY	-LSB- Calcium_receptor -LRB- CaR -RRB- : a new approach to regulation of calcium homeostasis -RSB- .
22940747	0	calcium	27,34	CaR	45,48	calcium	CaR	MESH:D002118	846	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Allosteric agonists of the calcium receptor -LRB- CaR -RRB- : fluorine and SF5 analogues of cinacalcet .
23094155	1	calcium	219,226	CaR	236,239	calcium	VDR	MESH:D002118	24873(Tax:10116)	Chemical	Gene	sensing|compound|START_ENTITY sensing|appos|END_ENTITY	Secondary_hyperparathyroidism -LRB- s-HPT -RRB- in uremia is characterized by decreased expression in the parathyroids of calcium sensing -LRB- CaR -RRB- and vitamin_D receptors -LRB- VDR -RRB- .
11097838	0	calcium	6,13	CaT1	32,36	calcium	CaT1	MESH:D002118	6541	Chemical	Gene	transport|nsubj|START_ENTITY transport|dobj|END_ENTITY	Human calcium transport protein CaT1 .
11287959	0	calcium	68,75	CaT1	0,4	calcium	CaT1	MESH:D002118	55503	Chemical	Gene	channel|compound|START_ENTITY properties|nmod|channel manifests|dobj|properties manifests|nsubj|END_ENTITY	CaT1 manifests the pore properties of the calcium-release-activated calcium channel .
11545681	0	calcium	73,80	CaT1	57,61	calcium	CaT1	MESH:D002118	55503	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	1,25-Dihydroxyvitamin _ D3 increases the expression of the CaT1 epithelial calcium channel in the Caco-2 human intestinal cell line .
12361955	0	calcium	40,47	CaT1	0,4	calcium	CaT1	MESH:D002118	55503	Chemical	Gene	current|compound|START_ENTITY contributes|nmod|current contributes|nsubj|END_ENTITY	CaT1 contributes to the stores-operated calcium current in Jurkat T-lymphocytes .
15689539	0	calcium	29,36	CaV1	15,19	calcium	CaV1	MESH:D002118	25404(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY Association|dep|channels Association|nmod|END_ENTITY	Association of CaV1 .3 L-type calcium channels with Shank .
23811053	0	calcium	62,69	CaV1	43,47	calcium	CaV1	MESH:D002118	857	Chemical	Gene	function|compound|START_ENTITY voltage-gated|dobj|function voltage-gated|nsubj|states states|nmod|END_ENTITY	Apo states of calmodulin and CaBP1 control CaV1 voltage-gated calcium channel function through direct competition for the IQ domain .
25675390	0	calcium	25,32	CaV1	0,4	calcium	CaV1	MESH:D002118	25404(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|nummod|.2 .2|nummod|END_ENTITY	CaV1 .2 and CaV1 .3 L-type calcium channels regulate the resting membrane potential but not the expression of calcium transporters in differentiated PC12 cells .
19718034	0	calcium	17,24	CaV2	12,16	calcium	CaV2	MESH:D002118	493642(Tax:9913)	Chemical	Gene	traffic|compound|START_ENTITY traffic|compound|END_ENTITY	Presynaptic CaV2 calcium channel traffic requires CALF-1 and the alpha -LRB- 2 -RRB- delta subunit UNC-36 .
21150296	0	calcium	90,97	CaV2	85,89	calcium	CaV2	MESH:D002118	858	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	The neuronal splicing factor Nova controls alternative splicing in N-type and P-type CaV2 calcium channels .
21150298	0	calcium	43,50	CaV2	24,28	calcium	CaV2	MESH:D002118	858	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	G protein modulation of CaV2 voltage-gated calcium channels .
25907097	0	calcium	139,146	CaV2	134,138	calcium	CaV2	MESH:D002118	179838(Tax:6239)	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Presynaptic BK channel localization is dependent on the hierarchical organization of alpha-catulin and dystrobrevin and fine-tuned by CaV2 calcium channels .
17855364	0	calcium	48,55	CaV3	36,40	calcium	CaV3	MESH:D002118	859	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Temperature-dependent modulation of CaV3 T-type calcium channels by protein kinases C and A in mammalian cells .
21099341	0	calcium	69,76	CaV3	57,61	calcium	CaV3	MESH:D002118	859	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Characterization of the gating brake in the I-II loop of CaV3 T-type calcium channels .
23652430	0	calcium	42,49	CaV3	60,64	calcium	CaV3	MESH:D002118	859	Chemical	Gene	channels|compound|START_ENTITY channels|appos|END_ENTITY	Revealing of T-type low-voltage activated calcium channels -LRB- CaV3 -RRB- in frog neuromuscular junctions .
24705276	0	calcium	14,21	CaV3	0,4	calcium	CaV3	MESH:D002118	29161(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|nummod|.2 .2|compound|END_ENTITY	CaV3 .2 T-type calcium channels in peripheral sensory neurons are important for mibefradil-induced reversal of hyperalgesia and allodynia in rats with painful_diabetic_neuropathy .
24800894	0	calcium	28,35	CaV3	14,18	calcium	CaV3	MESH:D002118	29161(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|nummod|.2 .2|compound|END_ENTITY	Inhibition of CaV3 .2 T-type calcium channels in peripheral sensory neurons contributes to analgesic properties of epipregnanolone .
19854154	0	calcium	20,27	Cacna1a	114,121	calcium	Cacna1a	MESH:D002118	12286(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY Knockdown|nmod|channels sufficient|nsubj|Knockdown sufficient|xcomp|induce induce|xcomp|occurring occurring|dobj|mutants mutants|amod|END_ENTITY	Knockdown of Cav2 .1 calcium channels is sufficient to induce neurological_disorders observed in natural occurring Cacna1a mutants in mice .
22005682	0	calcium	68,75	Cacna1a	106,113	calcium	Cacna1a	MESH:D002118	12286(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|model model|amod|END_ENTITY	Trigeminal ganglion neuron subtype-specific alterations of Ca -LRB- V -RRB- 2.1 calcium current and excitability in a Cacna1a mouse model of migraine .
21486818	0	calcium	90,97	Cacna1c	130,137	calcium	Cacna1c	MESH:D002118	775	Chemical	Gene	alpha|compound|START_ENTITY transcription|nmod|alpha represses|dobj|transcription kinase|acl:relcl|represses +|dep|kinase +|dep|gene gene|appos|END_ENTITY	Ca2 + - calmodulin-dependent protein kinase II represses cardiac transcription of the L-type calcium channel alpha -LRB- 1C -RRB- - subunit gene -LRB- Cacna1c -RRB- by DREAM translocation .
25989111	0	calcium	72,79	Cacna1c	93,100	calcium	Cacna1c	MESH:D002118	12288(Tax:10090)	Chemical	Gene	gene|compound|START_ENTITY cognitive_decline|nmod|gene END_ENTITY|amod|cognitive_decline	Sex-dependent modulation of age-related cognitive_decline by the L-type calcium channel gene Cacna1c -LRB- Cav 1.2 -RRB- .
20371816	0	calcium	64,71	Cacna1g	86,93	calcium	Cacna1g	MESH:D002118	12291(Tax:10090)	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	LEF1/beta-catenin complex regulates transcription of the Cav3 .1 calcium channel gene -LRB- Cacna1g -RRB- in thalamic neurons of the adult brain .
18952919	0	calcium	59,66	Cacna1s	51,58	calcium	Cacna1s	MESH:D002118	12292(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Effects of presynaptic mutations on a postsynaptic Cacna1s calcium channel colocalized with mGluR6 at mouse photoreceptor ribbon synapses .
9060410	0	calcium	26,33	Cacnl1a4	17,25	calcium	Cacnl1a4	MESH:D002118	12286(Tax:10090)	Chemical	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Mutations in the Cacnl1a4 calcium channel gene are associated with seizures , cerebellar_degeneration , and ataxia in tottering and leaner mutant mice .
11292831	6	calcium	940,947	CalDAG-GEFI	1016,1027	calcium	CalDAG-GEFI	MESH:D002118	361714(Tax:10116)	Chemical	Gene	I|amod|START_ENTITY I|appos|END_ENTITY	Using specific antibodies , we show that a recently identified Rap1 GEF , calcium - and diacylglycerol-regulated guanine_nucleotide exchange factor I -LRB- CalDAG-GEFI -RRB- , is expressed in PC12D cells and that carbachol stimulates the formation of a complex containing CalDAG-GEFI , Rap1 , and activated B-Raf .
2536235	0	calcium	29,36	Calbindin-D9k	0,13	calcium	Calbindin-D9k	MESH:D002118	24249(Tax:10116)	Chemical	Gene	pump|compound|START_ENTITY stimulates|dobj|pump stimulates|nsubj|END_ENTITY	Calbindin-D9k stimulates the calcium pump in rat enterocyte basolateral membranes .
17983652	0	calcium	99,106	Calcitonin	0,10	calcium	Calcitonin	MESH:D002118	24241(Tax:10116)	Chemical	Gene	mobilization|compound|START_ENTITY involvement|nmod|mobilization outgrowth|dep|involvement promotes|dobj|outgrowth promotes|nsubj|END_ENTITY	Calcitonin promotes outgrowth of trophoblast cells on endometrial epithelial cells : involvement of calcium mobilization and protein_kinase_C activation .
2497988	0	calcium	46,53	Calcitonin	0,10	calcium	Calcitonin	MESH:D002118	24241(Tax:10116)	Chemical	Gene	rise|nmod|START_ENTITY inhibits|dobj|rise inhibits|nsubj|END_ENTITY	Calcitonin inhibits the rise of intracellular calcium induced by thyrotropin-releasing_hormone in GH3 cells .
6303033	0	calcium	21,28	Calcitonin	0,10	calcium	Calcitonin	MESH:D002118	24241(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|increases increases|compound|END_ENTITY	Calcitonin increases calcium content and glucose-6-phosphatase activity in hepatic microsomes of rats .
6437957	0	calcium	66,73	Calcitonin	0,10	calcium	Calcitonin	MESH:D002118	24241(Tax:10116)	Chemical	Gene	related|nmod|START_ENTITY activity|acl|related increases|dobj|activity increases|nsubj|END_ENTITY	Calcitonin increases alanine aminotransferase activity related to calcium in the hepatic mitochondria of rats .
7182181	0	calcium	21,28	Calcitonin	0,10	calcium	Calcitonin	MESH:D002118	24241(Tax:10116)	Chemical	Gene	content|compound|START_ENTITY increases|dobj|content increases|nsubj|END_ENTITY	Calcitonin increases calcium content and phosphorylase a activity in the hepatic particulate glycogen of rats .
20951369	0	calcium	76,83	Calcitonin_gene-related_peptide	0,31	calcium	Calcitonin gene-related peptide	MESH:D002118	796	Chemical	Gene	facilitation|nmod|START_ENTITY facilitation|amod|END_ENTITY	Calcitonin_gene-related_peptide - and adrenomedullin-induced facilitation of calcium current in submandibular ganglion .
2549427	0	calcium	42,49	Calcitonin_gene-related_peptide	0,31	calcium	Calcitonin gene-related peptide	MESH:D002118	796	Chemical	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Calcitonin_gene-related_peptide regulates calcium current in heart muscle .
2843797	0	calcium	41,48	Calcitonin_gene-related_peptide	0,31	calcium	Calcitonin gene-related peptide	MESH:D002118	24241(Tax:10116)	Chemical	Gene	current|compound|START_ENTITY enhances|dobj|current enhances|nsubj|END_ENTITY	Calcitonin_gene-related_peptide enhances calcium current of rat dorsal root ganglion neurons and spinal excitatory synaptic transmission .
8603612	0	calcium	49,56	Calcitonin_gene-related_peptide	0,31	calcium	Calcitonin gene-related peptide	MESH:D002118	24241(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY inhibits|dobj|uptake inhibits|nsubj|END_ENTITY	Calcitonin_gene-related_peptide rapidly inhibits calcium uptake in osteoblastic cell lines via activation of adenosine_triphosphate-sensitive potassium channels .
14508624	0	calcium	72,79	Calcium-sensing_receptor	0,24	calcium	Calcium-sensing receptor	MESH:D002118	846	Chemical	Gene	level|compound|START_ENTITY predict|dobj|level predict|nsubj|A986S A986S|compound|END_ENTITY	Calcium-sensing_receptor gene polymorphism A986S does not predict serum calcium level , bone mineral density , calcaneal ultrasound indices , or fracture rate in a large cohort of elderly women .
17426287	0	calcium	57,64	Calcium-sensing_receptor	0,24	calcium	Calcium-sensing receptor	MESH:D002118	846	Chemical	Gene	links|dobj|START_ENTITY links|nsubj|endocytosis endocytosis|compound|END_ENTITY	Calcium-sensing_receptor endocytosis links extracellular calcium signaling to parathyroid hormone-related peptide secretion via a Rab11a-dependent and AMSH-sensitive mechanism .
21940718	0	calcium	124,131	Calcium-sensing_receptor	0,24	calcium	Calcium-sensing receptor	MESH:D002118	832370(Tax:3702)	Chemical	Gene	extracellular|dobj|START_ENTITY regulates|advcl|extracellular regulates|nsubj|END_ENTITY	Calcium-sensing_receptor regulates stomatal closure through hydrogen_peroxide and nitric_oxide in response to extracellular calcium in Arabidopsis .
22660550	0	calcium	61,68	Calcium-sensing_receptor	0,24	calcium	Calcium-sensing receptor	MESH:D002118	846	Chemical	Gene	nephrolithiasis|compound|START_ENTITY patients|nmod|nephrolithiasis polymorphisms|nmod|patients polymorphisms|nsubj|gene gene|compound|END_ENTITY	Calcium-sensing_receptor gene polymorphisms in patients with calcium nephrolithiasis .
23856265	0	calcium	59,66	Calcium-sensing_receptor	0,24	calcium	Calcium-sensing receptor	MESH:D002118	846	Chemical	Gene	metabolism|compound|START_ENTITY mutations|nmod|metabolism END_ENTITY|dep|mutations	Calcium-sensing_receptor -LRB- CaSR -RRB- mutations and disorders of calcium , electrolyte and water metabolism .
25019182	0	calcium	61,68	Calcium-sensing_receptor	0,24	calcium	Calcium-sensing receptor	MESH:D002118	846	Chemical	Gene	urolithiasis|compound|START_ENTITY patients|nmod|urolithiasis polymorphisms|nmod|patients polymorphisms|amod|END_ENTITY	Calcium-sensing_receptor gene polymorphisms in patients with calcium urolithiasis : a systematic review .
8732686	0	calcium	68,75	Calcium-sensing_receptor	0,24	calcium	Calcium-sensing receptor	MESH:D002118	12374(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Calcium-sensing_receptor expression and regulation by extracellular calcium in the AtT-20 pituitary cell line .
22708524	0	calcium	74,81	Calcium_sensing_receptor	0,24	calcium	Calcium sensing receptor	MESH:D002118	24247(Tax:10116)	Chemical	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Calcium_sensing_receptor regulates cardiomyocyte function through nuclear calcium .
10197534	0	calcium	73,80	Calmodulin	0,10	calcium	Calmodulin	MESH:D002118	808	Chemical	Gene	channels|compound|START_ENTITY inactivation|nmod|channels sensor|dep|inactivation sensor|nsubj|END_ENTITY	Calmodulin is the Ca2 + sensor for Ca2 + - dependent inactivation of L-type calcium channels .
10631259	0	calcium	58,65	Calmodulin	0,10	calcium	Calmodulin	MESH:D002118	852406(Tax:4932)	Chemical	Gene	pump|compound|START_ENTITY activation|nmod|pump activation|compound|END_ENTITY	Calmodulin activation of an endoplasmic reticulum-located calcium pump involves an interaction with the N-terminal autoinhibitory domain .
12196518	0	calcium	57,64	Calmodulin	0,10	calcium	Calmodulin	MESH:D002118	100759184	Chemical	Gene	release|nmod|START_ENTITY period|nmod|release modulates|dobj|period modulates|nsubj|END_ENTITY	Calmodulin modulates the delay period between release of calcium from internal stores and activation of calcium influx via endogenous TRP1 channels .
15496482	0	calcium	64,71	Calmodulin	0,10	calcium	Calmodulin	MESH:D002118	808	Chemical	Gene	channels|compound|START_ENTITY peptides|nmod|channels peptides|nsubj|interactions interactions|compound|END_ENTITY	Calmodulin interactions with IQ peptides from voltage-dependent calcium channels .
16203736	0	calcium	80,87	Calmodulin	0,10	calcium	Calmodulin	MESH:D002118	808	Chemical	Gene	sensor|compound|START_ENTITY involved|nmod|sensor involved|nsubjpass|END_ENTITY	Calmodulin is involved in the Ca2 + - dependent activation of ceramide_kinase as a calcium sensor .
16274254	0	calcium	99,106	Calmodulin	0,10	calcium	Calmodulin	MESH:D002118	808	Chemical	Gene	region|nmod|START_ENTITY regulation|nmod|region regulation|compound|END_ENTITY	Calmodulin regulation and identification of calmodulin binding region of type-3 ryanodine receptor calcium release channel .
18446197	0	calcium	25,32	Calmodulin	0,10	calcium	Calmodulin	MESH:D002118	808	Chemical	Gene	transients|compound|START_ENTITY activation|nmod|transients activation|nsubj|END_ENTITY	Calmodulin activation by calcium transients in the postsynaptic density of dendritic spines .
19226536	0	calcium	57,64	Calmodulin	0,10	calcium	Calmodulin	MESH:D002118	24242(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|compound|END_ENTITY	Calmodulin effects on steroids-regulated plasma membrane calcium pump activity .
21798306	0	calcium	49,56	Calmodulin	0,10	calcium	Calmodulin	MESH:D002118	808	Chemical	Gene	proteins|nmod|START_ENTITY proteins|compound|END_ENTITY	Calmodulin and calmodulin-like proteins in plant calcium signaling .
3367364	0	calcium	54,61	Calmodulin	0,10	calcium	Calmodulin	MESH:D002118	808	Chemical	Gene	effects|nmod|START_ENTITY intermediary|nmod|effects acts|nmod|intermediary acts|nsubj|END_ENTITY	Calmodulin acts as an intermediary for the effects of calcium on gap junctions from crayfish lateral axons .
6277527	1	calcium	81,88	Calmodulin	24,34	calcium	Calmodulin	MESH:D002118	808	Chemical	Gene	sensitivity|compound|START_ENTITY kinase|nmod|sensitivity kinase|compound|END_ENTITY	Calmodulin and cyclic_AMP-dependent protein kinase after calcium sensitivity in porcine carotid skinned fibers .
6622516	0	calcium	31,38	Calmodulin	0,10	calcium	Calmodulin	MESH:D002118	808	Chemical	Gene	binding|nsubj|START_ENTITY enhance|xcomp|binding enhance|nsubj|antagonists antagonists|compound|END_ENTITY	Calmodulin antagonists enhance calcium binding to calmodulin .
7605608	1	calcium	61,68	Calmodulin	37,47	calcium	Calmodulin	MESH:D002118	808	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|dep|protein	Calmodulin : a versatile calcium mediator protein .
8286381	0	calcium	71,78	Calmodulin	0,10	calcium	Calmodulin	MESH:D002118	100682497	Chemical	Gene	protein|compound|START_ENTITY interaction|nmod|protein interaction|nsubj|END_ENTITY	Calmodulin interaction with the skeletal muscle sarcoplasmic reticulum calcium channel protein .
8706879	0	calcium	20,27	Calmodulin	0,10	calcium	Calmodulin	MESH:D002118	326597(Tax:9913)	Chemical	Gene	current|compound|START_ENTITY inhibits|dobj|current inhibits|nsubj|END_ENTITY	Calmodulin inhibits calcium influx current in vascular endothelium .
9027311	0	calcium	25,32	Calmodulin	0,10	calcium	Calmodulin	MESH:D002118	36329(Tax:7227)	Chemical	Gene	stores|compound|START_ENTITY regulation|nmod|stores regulation|compound|END_ENTITY	Calmodulin regulation of calcium stores in phototransduction of Drosophila .
10213498	0	calcium	85,92	Calreticulin	0,12	calcium	Calreticulin	MESH:D002118	811	Chemical	Gene	associated|xcomp|START_ENTITY associated|nsubjpass|expression expression|compound|END_ENTITY	Calreticulin expression is associated with androgen regulation of the sensitivity to calcium ionophore-induced apoptosis in LNCaP_prostate_cancer cells .
10749940	0	calcium	21,28	Calreticulin	0,12	calcium	Calreticulin	MESH:D002118	811	Chemical	Gene	release|compound|START_ENTITY couples|dobj|release couples|nsubj|END_ENTITY	Calreticulin couples calcium release and calcium influx in integrin-mediated calcium signaling .
10749940	0	calcium	77,84	Calreticulin	0,12	calcium	Calreticulin	MESH:D002118	811	Chemical	Gene	release|nmod|START_ENTITY couples|dobj|release couples|nsubj|END_ENTITY	Calreticulin couples calcium release and calcium influx in integrin-mediated calcium signaling .
12324449	0	calcium	38,45	Calreticulin	0,12	calcium	Calreticulin	MESH:D002118	811	Chemical	Gene	uptake|compound|START_ENTITY modulates|dobj|uptake modulates|nsubj|END_ENTITY	Calreticulin differentially modulates calcium uptake and release in the endoplasmic reticulum and mitochondria .
2016321	0	calcium	50,57	Calreticulin	0,12	calcium	Calreticulin	MESH:D002118	100350417(Tax:9986)	Chemical	Gene	protein|compound|START_ENTITY protein|nsubj|END_ENTITY	Calreticulin , and not calsequestrin , is the major calcium binding protein of smooth muscle sarcoplasmic reticulum and liver endoplasmic reticulum .
21554974	0	calcium	28,35	Calreticulin	0,12	calcium	Calreticulin	MESH:D002118	811	Chemical	Gene	homeostasis|compound|START_ENTITY mediated|nsubj|homeostasis crucial|advcl|mediated crucial|nsubj|END_ENTITY	Calreticulin is crucial for calcium homeostasis mediated adaptation and survival of thick ascending limb of Henle 's loop cells under osmotic stress .
23791743	0	calcium	74,81	Calreticulin	0,12	calcium	Calreticulin	MESH:D002118	811	Chemical	Gene	channel|compound|START_ENTITY expression|nmod|channel regulates|dobj|expression regulates|nsubj|END_ENTITY	Calreticulin negatively regulates the surface expression of Cav1 .3 L-type calcium channel .
8676889	0	calcium	61,68	Calreticulin	0,12	calcium	Calreticulin	MESH:D002118	811	Chemical	Gene	metals|compound|START_ENTITY upregulated|nmod|metals upregulated|nsubjpass|END_ENTITY	Calreticulin is transcriptionally upregulated by heat_shock , calcium and heavy metals .
9126744	0	calcium	48,55	Calreticulin	0,12	calcium	Calreticulin	MESH:D002118	12317(Tax:10090)	Chemical	Gene	signalling|compound|START_ENTITY essential|nmod|signalling essential|nsubj|END_ENTITY	Calreticulin is essential for integrin-mediated calcium signalling and cell adhesion .
11058082	0	calcium	17,24	Calsequestrin	0,13	calcium	Calsequestrin	MESH:D002118	181563(Tax:6239)	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	Calsequestrin , a calcium sequestering protein localized at the sarcoplasmic reticulum , is not essential for body-wall muscle function in Caenorhabditis_elegans .
8523447	0	calcium	51,58	Cardiac_troponin_C	0,18	calcium	Cardiac troponin C	MESH:D002118	7134	Chemical	Gene	drug|compound|START_ENTITY protein|nmod|drug END_ENTITY|nmod|protein	Cardiac_troponin_C as a target protein for a novel calcium sensitizing drug , levosimendan .
10428052	0	calcium	67,74	Caspase-3	0,9	calcium	Caspase-3	MESH:D002118	25402(Tax:10116)	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	Caspase-3 expression by cerebellar granule neurons is regulated by calcium and cyclic_AMP .
24430778	0	calcium	12,19	CatSper	4,11	calcium	CatSper	MESH:D002118	117144	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	The CatSper calcium channel in human sperm : relation with motility and involvement in progesterone-induced acrosome_reaction .
20167851	0	calcium	19,26	Cav1	14,18	calcium	Cav1	MESH:D002118	12389(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Knocking down Cav1 calcium channels implicated in Th2 cell activation prevents experimental asthma .
17132857	0	calcium	36,43	Cav2	31,35	calcium	Cav2	MESH:D002118	858	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Direct G protein modulation of Cav2 calcium channels .
18471074	0	calcium	88,95	Cav2	83,87	calcium	Cav2	MESH:D002118	858	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	A high-throughput assay for evaluating state dependence and subtype selectivity of Cav2 calcium channel inhibitors .
26247695	0	calcium	48,55	Cav2	67,71	calcium	Cav2	MESH:D002118	363425(Tax:10116)	Chemical	Gene	modulation|compound|START_ENTITY modulation|compound|END_ENTITY	Electrophysiological evidence for voltage-gated calcium channel 2 -LRB- Cav2 -RRB- modulation of mechano - and thermosensitive spinal neuronal responses in a rat model of osteoarthritis .
15254077	0	calcium	65,72	Cav3	58,62	calcium	Cav3	MESH:D002118	859	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Functional impact of alternative splicing of human T-type Cav3 .3 calcium channels .
21639922	0	calcium	33,40	Cav3	19,23	calcium	Cav3	MESH:D002118	12391(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Involvement of the Cav3 .2 T-type calcium channel in thalamic neuron discharge patterns .
1594624	0	calcium	131,138	Cholecystokinin	0,15	calcium	Cholecystokinin	MESH:D002118	25298(Tax:10116)	Chemical	Gene	increase|nmod|START_ENTITY monitor|nmod|increase respond|xcomp|monitor respond|nsubj|cells cells|compound|END_ENTITY	Cholecystokinin cells purified by fluorescence-activated cell sorting respond to monitor peptide with an increase in intracellular calcium .
2550000	0	calcium	35,42	Cholecystokinin	0,15	calcium	Cholecystokinin	MESH:D002118	885	Chemical	Gene	elevates|dobj|START_ENTITY elevates|nsubj|END_ENTITY	Cholecystokinin elevates cytosolic calcium in small_cell_lung_cancer cells .
2740351	0	calcium	106,113	Cholecystokinin	0,15	calcium	Cholecystokinin	MESH:D002118	25298(Tax:10116)	Chemical	Gene	neural|nmod|START_ENTITY evokes|nmod|neural evokes|nsubj|END_ENTITY	Cholecystokinin evokes secretion of oxytocin and vasopressin from rat neural lobe independent of external calcium .
7861766	0	calcium	51,58	Cholecystokinin	0,15	calcium	Cholecystokinin	MESH:D002118	885	Chemical	Gene	ionized|dobj|START_ENTITY ionized|nsubj|effect effect|compound|END_ENTITY	Cholecystokinin effect on human lymphocyte ionized calcium and mitogenesis .
22851679	0	calcium	55,62	Chromogranin_A	0,14	calcium	Chromogranin A	MESH:D002118	1113	Chemical	Gene	granules|nmod|START_ENTITY biogenesis|nmod|granules induces|dobj|biogenesis induces|nsubj|END_ENTITY	Chromogranin_A induces the biogenesis of granules with calcium - and actin-dependent dynamics and exocytosis in constitutively secreting cells .
19878772	0	calcium	47,54	Clusterin	25,34	calcium	Clusterin	MESH:D002118	1191	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Chapter 4 : Regulation of Clusterin activity by calcium .
24766160	0	calcium	61,68	Cyclin-dependent_kinase_5	14,39	calcium	Cyclin-dependent kinase 5	MESH:D002118	140908(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|nmod|channels	The effect of Cyclin-dependent_kinase_5 on voltage-dependent calcium channels in PC12 cells varies according to channel type and cell differentiation state .
11246611	0	calcium	119,126	E-cadherin	16,26	calcium	E-cadherin	MESH:D002118	83502(Tax:10116)	Chemical	Gene	influx|nmod|START_ENTITY functions|nmod|influx stabilize|dobj|functions stimulates|advcl|stabilize stimulates|dobj|expression expression|amod|END_ENTITY	Acid stimulates E-cadherin surface expression on gastric epithelial cells to stabilize barrier functions via influx of calcium .
12517779	0	calcium	14,21	E-cadherin	100,110	calcium	E-cadherin	MESH:D002118	999	Chemical	Gene	START_ENTITY|dep|promotion promotion|nmod|expression expression|amod|END_ENTITY	Extracellular calcium and calcium_sensing_receptor function in human colon_carcinomas : promotion of E-cadherin expression and suppression of beta-catenin/TCF activation .
1373144	1	calcium	123,130	E-cadherin	213,223	calcium	E-cadherin	MESH:D002118	999	Chemical	Gene	concentration|compound|START_ENTITY Elevation|nmod|concentration induces|nsubj|Elevation induces|dobj|redistribution redistribution|nmod|END_ENTITY	Elevation of the calcium concentration in human keratinocyte culture rapidly induces the redistribution of E-cadherin , P-cadherin , vinculin , beta_1_integrin , and desmoplakin to the cell-cell borders .
8055942	0	calcium	82,89	E-cadherin	66,76	calcium	E-cadherin	MESH:D002118	999	Chemical	Gene	changes|nmod|START_ENTITY changes|nmod|END_ENTITY	Conformational changes of the recombinant extracellular domain of E-cadherin upon calcium binding .
9409761	0	calcium	60,67	E-cadherin	25,35	calcium	E-cadherin	MESH:D002118	999	Chemical	Gene	directed|nmod|START_ENTITY directed|nsubj|self-assembly self-assembly|nmod|END_ENTITY	Lateral self-assembly of E-cadherin directed by cooperative calcium binding .
9700170	0	calcium	54,61	E-cadherin	25,35	calcium	E-cadherin	MESH:D002118	999	Chemical	Gene	require|dobj|START_ENTITY require|nsubj|complexes complexes|amod|END_ENTITY	Adhesive but not lateral E-cadherin complexes require calcium and catenins for their formation .
22973849	7	calcium	998,1005	EFhd2	992,997	calcium	EFhd2	MESH:D002118	79180	Chemical	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Furthermore , characterization of an identified single-nucleotide polymorphisms -LRB- SNP -RRB- that introduced a missense mutation indicates the importance of a conserved phenylalanine on EFhd2 calcium binding activity .
11133526	0	calcium	86,93	ERK	18,21	calcium	ERK	MESH:D002118	5594	Chemical	Gene	requires|dobj|START_ENTITY requires|nsubj|Urea Urea|acl|signaling signaling|xcomp|END_ENTITY	Urea signaling to ERK phosphorylation in renal medullary cells requires extracellular calcium but not calcium entry .
11278479	0	calcium	60,67	ERK	12,15	calcium	ERK	MESH:D002118	5594	Chemical	Gene	entry|compound|START_ENTITY activation|nmod|entry Role|nmod|activation Role|nmod|pathway pathway|compound|END_ENTITY	Role of the ERK pathway in the activation of store-mediated calcium entry in human platelets .
12161078	0	calcium	76,83	ERK	4,7	calcium	ERK	MESH:D002118	5594	Chemical	Gene	entry|compound|START_ENTITY activation|nmod|entry involved|nmod|activation pathway|acl|involved cascade|appos|pathway cascade|compound|END_ENTITY	The ERK cascade , a new pathway involved in the activation of store-mediated calcium entry in human platelets .
14584892	0	calcium	14,21	ERK	96,99	calcium	ERK	MESH:D002118	26413(Tax:10090)	Chemical	Gene	inducer|nsubj|START_ENTITY inducer|nmod|END_ENTITY	Extracellular calcium is a potent inducer of cyclo-oxygenase-2 in murine osteoblasts through an ERK signaling pathway .
16054119	0	calcium	7,14	ERK	59,62	calcium	ERK	MESH:D002118	5594	Chemical	Gene	channel|compound|START_ENTITY trigger|nsubj|channel trigger|dobj|p21ras p21ras|acl|signaling signaling|nmod|END_ENTITY	T-type calcium channel trigger p21ras signaling pathway to ERK in Cav3.1-expressed HEK293 cells .
16630542	0	calcium	123,130	ERK	81,84	calcium	ERK	MESH:D002118	24338(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY elevating|dobj|concentration rat|advcl|elevating rat|nmod|activation activation|compound|END_ENTITY	Sonic hedgehog stimulates the proliferation of rat gastric mucosal cells through ERK activation by elevating intracellular calcium concentration .
19560418	0	calcium	84,91	ERK	46,49	calcium	ERK	MESH:D002118	5594	Chemical	Gene	signals|compound|START_ENTITY promotes|nmod|signals promotes|dobj|activation activation|compound|END_ENTITY	KSR2 is a calcineurin substrate that promotes ERK cascade activation in response to calcium signals .
9870922	0	calcium	76,83	ERK	22,25	calcium	ERK	MESH:D002118	5594	Chemical	Gene	influx|compound|START_ENTITY requires|dobj|influx requires|nsubj|activation activation|compound|END_ENTITY	Endothelin-stimulated ERK activation in airway_smooth-muscle cells requires calcium influx and Raf activation .
23519605	0	calcium	93,100	ERK1/2	133,139	calcium	ERK1/2	MESH:D002118	26417;26413	Chemical	Gene	channels|compound|START_ENTITY channels|nmod|END_ENTITY	The induction of cardiac_ornithine_decarboxylase by b2 - adrenergic agents is associated with calcium channels and phosphorylation of ERK1/2 .
24009711	0	calcium	39,46	ERK1/2	14,20	calcium	ERK1/2	MESH:D002118	50689;116590	Chemical	Gene	entry|compound|START_ENTITY END_ENTITY|nmod|entry	Activation of ERK1/2 by store-operated calcium entry in rat parotid acinar cells .
24815697	0	calcium	30,37	ERp57	0,5	calcium	ERp57	MESH:D002118	2923	Chemical	Gene	uptake|compound|START_ENTITY modulates|dobj|uptake modulates|nsubj|END_ENTITY	ERp57 modulates mitochondrial calcium uptake through the MCU .
21515378	0	calcium	40,47	ET-1	0,4	calcium	ET-1	MESH:D002118	1906	Chemical	Gene	Elevation|nmod|START_ENTITY Elevation|compound|END_ENTITY	ET-1 induced Elevation of intracellular calcium in clonal neuronal and embryonic kidney cells involves endogenous endothelin-A receptors linked to phospholipase C through Ga -LRB- q/11 -RRB- .
8717152	0	calcium	77,84	ET-2	28,32	calcium	ET-2	MESH:D002118	1907	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of endothelin-2 -LRB- ET-2 -RRB- on migration and changes in cytosolic free calcium of neutrophils .
21216957	0	calcium	92,99	EZH2	0,4	calcium	EZH2	MESH:D002118	2146	Chemical	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	EZH2 regulates neuronal differentiation of mesenchymal stem cells through PIP5K1C-dependent calcium signaling .
11726808	0	calcium	65,72	Endothelin-1	0,12	calcium	Endothelin-1	MESH:D002118	24323(Tax:10116)	Chemical	Gene	increase|dobj|START_ENTITY receptors|xcomp|increase receptors|nsubj|ET ET|compound|END_ENTITY	Endothelin-1 activates ET -LRB- A -RRB- receptors to increase intracellular calcium in model sensory neurons .
12388321	0	calcium	23,30	Endothelin-1	0,12	calcium	Endothelin-1	MESH:D002118	13614(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|increases increases|amod|END_ENTITY	Endothelin-1 increases calcium and attenuates renin gene expression in As4 .1 cells .
1327578	0	calcium	22,29	Endothelin-1	0,12	calcium	Endothelin-1	MESH:D002118	24323(Tax:10116)	Chemical	Gene	entry|compound|START_ENTITY enhances|dobj|entry enhances|nsubj|END_ENTITY	Endothelin-1 enhances calcium entry through T-type calcium channels in cultured neonatal rat ventricular myocytes .
1327578	0	calcium	51,58	Endothelin-1	0,12	calcium	Endothelin-1	MESH:D002118	24323(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY enhances|nmod|channels enhances|nsubj|END_ENTITY	Endothelin-1 enhances calcium entry through T-type calcium channels in cultured neonatal rat ventricular myocytes .
1508798	0	calcium	37,44	Endothelin-1	0,12	calcium	Endothelin-1	MESH:D002118	281137(Tax:9913)	Chemical	Gene	content|compound|START_ENTITY increases|dobj|content increases|nsubj|END_ENTITY	Endothelin-1 increases intracellular calcium content in bovine parathyroid endothelial cells .
1550575	0	calcium	40,47	Endothelin-1	0,12	calcium	Endothelin-1	MESH:D002118	24323(Tax:10116)	Chemical	Gene	mobilization|compound|START_ENTITY stimulate|dobj|mobilization END_ENTITY|dep|stimulate	Endothelin-1 and endothelin-3 stimulate calcium mobilization by different mechanisms in vascular smooth muscle .
18539650	0	calcium	38,45	Endothelin-1	0,12	calcium	Endothelin-1	MESH:D002118	1906	Chemical	Gene	channels|compound|START_ENTITY regulates|dobj|channels regulates|nsubj|END_ENTITY	Endothelin-1 regulates cardiac L-type calcium channels via NAD -LRB- P -RRB- H oxidase-derived superoxide .
20452970	0	calcium	106,113	Endothelin-1	0,12	calcium	Endothelin-1	MESH:D002118	1906	Chemical	Gene	remodeling|nmod|START_ENTITY expression|acl|remodeling increases|dobj|expression increases|nsubj|END_ENTITY	Endothelin-1 -LRB- ET-1 -RRB- increases the expression of remodeling genes in vascular smooth muscle through linked calcium and cAMP pathways : role of a phospholipase A -LRB- 2 -RRB- -LRB- cPLA -LRB- 2 -RRB- -RRB- / cyclooxygenase-2 -LRB- COX-2 -RRB- / prostacyclin receptor-dependent autocrine loop .
21445599	0	calcium	36,43	Endothelin-1	0,12	calcium	Endothelin-1	MESH:D002118	24323(Tax:10116)	Chemical	Gene	decay_in_neonatal_rat_cardiac_myocytes|compound|START_ENTITY intracellular|dobj|decay_in_neonatal_rat_cardiac_myocytes intracellular|nsubj|prolongs prolongs|amod|END_ENTITY	Endothelin-1 prolongs intracellular calcium transient decay_in_neonatal_rat_cardiac_myocytes .
2193256	0	calcium	35,42	Endothelin-1	0,12	calcium	Endothelin-1	MESH:D002118	24323(Tax:10116)	Chemical	Gene	rise|compound|START_ENTITY induces|dobj|rise induces|nsubj|END_ENTITY	Endothelin-1 induces intracellular calcium rise and inositol_1 ,4,5 - trisphosphate formation in cultured rat and human glioma cells .
2679558	0	calcium	37,44	Endothelin-1	0,12	calcium	Endothelin-1	MESH:D002118	100009270(Tax:9986)	Chemical	Gene	mobilization|compound|START_ENTITY increases|dobj|mobilization increases|nsubj|END_ENTITY	Endothelin-1 increases intracellular calcium mobilization but not calcium uptake in rabbit vascular smooth muscle cells .
8001384	0	calcium	37,44	Endothelin-1	0,12	calcium	Endothelin-1	MESH:D002118	1906	Chemical	Gene	increases|dobj|START_ENTITY increases|nsubj|END_ENTITY	Endothelin-1 increases intracellular calcium in human monocytes and causes production of interleukin-6 .
8213257	0	calcium	23,30	Endothelin-1	0,12	calcium	Endothelin-1	MESH:D002118	24323(Tax:10116)	Chemical	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	Endothelin-1 modulates calcium signaling by epidermal_growth_factor , alpha-thrombin , and prostaglandin_E1 in UMR-106 osteoblastic cells .
8588187	0	calcium	62,69	Endothelin-1	0,12	calcium	Endothelin-1	MESH:D002118	1906	Chemical	Gene	concentration|compound|START_ENTITY evoked|nmod|concentration evoked|nsubj|END_ENTITY	Endothelin-1 evoked an increase_and_oscillations in cytosolic calcium concentration in adherent single human platelets and increased GMP-140 -LRB- P-selectin -RRB- in platelet suspension .
8606524	0	calcium	48,55	Endothelin-1	0,12	calcium	Endothelin-1	MESH:D002118	1906	Chemical	Gene	involves|dobj|START_ENTITY involves|nsubj|release release|amod|END_ENTITY	Endothelin-1 release by erythropoietin involves calcium signaling in endothelial cells .
8764613	0	calcium	107,114	Endothelin-1	0,12	calcium	Endothelin-1	MESH:D002118	1906	Chemical	Gene	influx|nmod|START_ENTITY arachidonic_acid|nmod|influx arachidonic_acid|nsubj|increases increases|amod|END_ENTITY	Endothelin-1 increases arachidonic_acid release in C6_glioma cells through a potassium-modulated influx of calcium .
9776344	0	calcium	41,48	Endothelin-1	0,12	calcium	Endothelin-1	MESH:D002118	281137(Tax:9913)	Chemical	Gene	efflux|compound|START_ENTITY stimulates|dobj|efflux stimulates|nsubj|END_ENTITY	Endothelin-1 stimulates sodium-dependent calcium efflux from bovine adrenal chromaffin cells in culture .
1718168	0	calcium	28,35	Endothelin_1	0,12	calcium	Endothelin 1	MESH:D002118	13614(Tax:10090)	Chemical	Gene	increases|dobj|START_ENTITY increases|nsubj|END_ENTITY	Endothelin_1 increases cell calcium in mouse collecting tubule cells .
9861441	0	calcium	60,67	Endothelin_1	0,12	calcium	Endothelin 1	MESH:D002118	24323(Tax:10116)	Chemical	Gene	ions|compound|START_ENTITY action|nmod|ions action|amod|END_ENTITY	Endothelin_1 action on isolated rat stomach and the role of calcium ions in ET 1 induced depolarization of smooth muscle cells BC3H1 .
11134249	0	calcium	49,56	Epidermal_growth_factor	0,23	calcium	Epidermal growth factor	MESH:D002118	1950	Chemical	Gene	channels|compound|START_ENTITY activates|dobj|channels activates|nsubj|END_ENTITY	Epidermal_growth_factor activates store-operated calcium channels in human glomerular mesangial cells .
1322351	0	calcium	47,54	Epidermal_growth_factor	0,23	calcium	Epidermal growth factor	MESH:D002118	1950	Chemical	Gene	oscillations|compound|START_ENTITY induces|dobj|oscillations induces|nsubj|END_ENTITY	Epidermal_growth_factor induces dose-dependent calcium oscillations in single fura-2-loaded hepatocytes .
16832619	0	calcium	65,72	Epidermal_growth_factor	0,23	calcium	Epidermal growth factor	MESH:D002118	100008808(Tax:9986)	Chemical	Gene	regulation|nmod|START_ENTITY enhances|dobj|regulation enhances|nsubj|END_ENTITY	Epidermal_growth_factor enhances intracellular pH regulation via calcium signaling in acid-exposed primary cultured rabbit gastric epithelial cells .
2544610	0	calcium	138,145	Epidermal_growth_factor	0,23	calcium	Epidermal growth factor	MESH:D002118	25313(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY requirement|nmod|levels stimulation|dep|requirement stimulation|amod|END_ENTITY	Epidermal_growth_factor stimulation of prostacyclin production by cultured aortic smooth muscle cells : requirement for increased cellular calcium levels .
3093189	0	calcium	94,101	Epidermal_growth_factor	0,23	calcium	Epidermal growth factor	MESH:D002118	1950	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|nmod|transport	Epidermal_growth_factor in human milk and the effects of systemic EGF injection on intestinal calcium transport in suckling rats .
3121392	0	calcium	144,151	Epidermal_growth_factor	0,23	calcium	Epidermal growth factor	MESH:D002118	1950	Chemical	Gene	increase|dobj|START_ENTITY ionophore|ccomp|increase ionophore|nsubj|END_ENTITY	Epidermal_growth_factor -LRB- EGF -RRB- , tumor promoter 12-O-tetradecanoylphorbol_13-acetate -LRB- TPA -RRB- and calcium ionophore A23187 increase cytoplasmic free calcium and stimulate arachidonic_acid release and PGE2/6-keto _ PGF1 alpha production in cultured porcine thyroid cells .
3490496	1	calcium	138,145	Epidermal_growth_factor	45,68	calcium	Epidermal growth factor	MESH:D002118	1950	Chemical	Gene	elevation|nmod|START_ENTITY cause|dobj|elevation cause|nsubj|END_ENTITY	Epidermal_growth_factor and human transforming_growth_factor-alpha cause elevation of plasma calcium in mice .
6403530	0	calcium	88,95	Epidermal_growth_factor	0,23	calcium	Epidermal growth factor	MESH:D002118	25313(Tax:10116)	Chemical	Gene	synergistically|nmod|START_ENTITY synergistically|compound|END_ENTITY	Epidermal_growth_factor and thyrotropin-releasing_hormone interact synergistically with calcium to regulate prolactin mRNA levels .
8388615	0	calcium	175,182	Epidermal_growth_factor	0,23	calcium	Epidermal growth factor	MESH:D002118	25313(Tax:10116)	Chemical	Gene	concentration|nmod|START_ENTITY increasing|dobj|concentration stimulates|advcl|increasing stimulates|nsubj|END_ENTITY	Epidermal_growth_factor stimulates the prolactin synthesis and secretion in rat pituitary cells in culture -LRB- GH4C1 cells -RRB- by increasing the intracellular concentration of free calcium .
9087996	0	calcium	57,64	Epidermal_growth_factor	0,23	calcium	Epidermal growth factor	MESH:D002118	25313(Tax:10116)	Chemical	Gene	reduces|iobj|START_ENTITY reduces|nsubj|END_ENTITY	Epidermal_growth_factor reduces L-type voltage-activated calcium current density in GH4C1 rat pituitary cells .
10087335	0	calcium	39,46	Erythropoietin	0,14	calcium	Erythropoietin	MESH:D002118	2056	Chemical	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	Erythropoietin modulates intracellular calcium in a human neuroblastoma cell line .
12167663	0	calcium	25,32	Erythropoietin	0,14	calcium	Erythropoietin	MESH:D002118	13856(Tax:10090)	Chemical	Gene	influx|compound|START_ENTITY modulates|dobj|influx modulates|nsubj|END_ENTITY	Erythropoietin modulates calcium influx through TRPC2 .
1614280	0	calcium	37,44	Erythropoietin	0,14	calcium	Erythropoietin	MESH:D002118	2056	Chemical	Gene	influx|compound|START_ENTITY transmembrane|dobj|influx transmembrane|nsubj|induced induced|compound|END_ENTITY	Erythropoietin induced transmembrane calcium influx in essential hypertension .
2059226	0	calcium	109,116	Erythropoietin	0,14	calcium	Erythropoietin	MESH:D002118	24335(Tax:10116)	Chemical	Gene	increases|nmod|START_ENTITY increases|nsubj|END_ENTITY	Erythropoietin increases cytosolic free calcium concentration and thrombin induced changes in cytosolic free calcium in platelets from spontaneously hypertensive rats .
2059226	0	calcium	40,47	Erythropoietin	0,14	calcium	Erythropoietin	MESH:D002118	24335(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY increases|dobj|concentration increases|nsubj|END_ENTITY	Erythropoietin increases cytosolic free calcium concentration and thrombin induced changes in cytosolic free calcium in platelets from spontaneously hypertensive rats .
2649170	0	calcium	55,62	Erythropoietin	0,14	calcium	Erythropoietin	MESH:D002118	2056	Chemical	Gene	concentration|compound|START_ENTITY rise|nmod|concentration stimulates|dobj|rise stimulates|nsubj|END_ENTITY	Erythropoietin stimulates a rise in intracellular-free calcium concentration in single BFU-E derived erythroblasts at specific stages of differentiation .
3260614	0	calcium	61,68	Erythropoietin	0,14	calcium	Erythropoietin	MESH:D002118	2056	Chemical	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Erythropoietin induces rapid increases in intracellular free calcium in human bone marrow cells .
3292588	0	calcium	55,62	Erythropoietin	0,14	calcium	Erythropoietin	MESH:D002118	2056	Chemical	Gene	concentration|compound|START_ENTITY rise|nmod|concentration stimulates|dobj|rise stimulates|nsubj|END_ENTITY	Erythropoietin stimulates a rise in intracellular free calcium concentration in single early human erythroid precursors .
7536133	0	calcium	43,50	Erythropoietin	0,14	calcium	Erythropoietin	MESH:D002118	2056	Chemical	Gene	modulation|nmod|START_ENTITY modulation|compound|END_ENTITY	Erythropoietin modulation of intracellular calcium : a role for tyrosine phosphorylation .
8252582	0	calcium	40,47	Erythropoietin	0,14	calcium	Erythropoietin	MESH:D002118	24335(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY increases|dobj|concentration increases|nsubj|END_ENTITY	Erythropoietin increases cytosolic free calcium concentration in vascular smooth muscle cells .
23737983	0	calcium	76,83	Eukaryotic_translation_initiation_factor_3_subunit_e	0,52	calcium	Eukaryotic translation initiation factor 3 subunit e	MESH:D002118	3646	Chemical	Gene	homeostasis|compound|START_ENTITY controls|dobj|homeostasis controls|nsubj|END_ENTITY	Eukaryotic_translation_initiation_factor_3_subunit_e controls intracellular calcium homeostasis by regulation of cav1 .2 surface expression .
23443925	0	calcium	44,51	FGF23	0,5	calcium	FGF23	MESH:D002118	8074	Chemical	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	FGF23 is a novel regulator of intracellular calcium and cardiac contractility in addition to cardiac_hypertrophy .
7693682	1	calcium	144,151	FKBP-12	129,136	calcium	FKBP-12	MESH:D002118	2280	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|nmod|channel	Dissociation and reconstitution of FKBP-12 to the calcium release channel of skeletal muscle sarcoplasmic reticulum .
26239116	0	calcium	44,51	FKBP25	0,6	calcium	FKBP25	MESH:D002118	2287	Chemical	Gene	entry|compound|START_ENTITY regulate|dobj|entry regulate|nsubj|END_ENTITY	FKBP25 and FKBP38 regulate non-capacitative calcium entry through TRPC6 .
11108952	0	calcium	15,22	Fibrillin-1	0,11	calcium	Fibrillin-1	MESH:D002118	2200	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	Fibrillin-1 , a calcium binding protein of extracellular matrix .
12805215	0	calcium	49,56	GAP43	0,5	calcium	GAP43	MESH:D002118	2596	Chemical	Gene	release|compound|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	GAP43 stimulates inositol_trisphosphate-mediated calcium release in response to hypotonicity .
7702619	0	calcium	70,77	GFAP	60,64	calcium	GFAP	MESH:D002118	2670	Chemical	Gene	manner|amod|START_ENTITY END_ENTITY|nmod|manner	Annexin II2-p11 -LRB- 2 -RRB- -LRB- calpactin I -RRB- stimulates the assembly of GFAP in a calcium - and pH-dependent manner .
18971392	0	calcium	17,24	GLUT-4	45,51	calcium	GLUT-4	MESH:D002118	396754(Tax:9823)	Chemical	Gene	blocks|nsubj|START_ENTITY blocks|dobj|expression expression|compound|END_ENTITY	Chronic elevated calcium blocks AMPK-induced GLUT-4 expression in skeletal muscle .
26206086	0	calcium	23,30	GSK3b	57,62	calcium	GSK3b	MESH:D002118	2932	Chemical	Gene	crosstalk|compound|START_ENTITY regulated|nsubjpass|crosstalk regulated|nmod|END_ENTITY	The SR/ER-mitochondria calcium crosstalk is regulated by GSK3b during reperfusion injury .
26434983	0	calcium	23,30	GSK3b	57,62	calcium	GSK3b	MESH:D002118	2932	Chemical	Gene	crosstalk|compound|START_ENTITY regulated|nsubjpass|crosstalk regulated|nmod|END_ENTITY	The SR/ER-mitochondria calcium crosstalk is regulated by GSK3b during reperfusion injury .
7840138	0	calcium	58,65	G_alpha_q	0,9	calcium	G alpha q	MESH:D002118	2776	Chemical	Gene	regulate|dobj|START_ENTITY regulate|nsubj|END_ENTITY	G_alpha_q and G_alpha_13 regulate NHE-1 and intracellular calcium in epithelial cells .
3930881	0	calcium	60,67	Gastrin	0,7	calcium	Gastrin	MESH:D002118	2520	Chemical	Gene	ionophore|compound|START_ENTITY effects|nmod|ionophore release|dep|effects release|compound|END_ENTITY	Gastrin release from dispersed gastrinoma cells : effects of calcium and calcium ionophore -LRB- A23187 -RRB- .
10436043	0	calcium	105,112	Gbeta	124,129	calcium	Gbeta	MESH:D002118	8801	Chemical	Gene	channel|compound|START_ENTITY channel|nmod|END_ENTITY	Identification of residues in the N terminus of alpha1B critical for inhibition of the voltage-dependent calcium channel by Gbeta gamma .
27075443	0	calcium	32,39	Gdt1	6,10	calcium	Gdt1	MESH:D002118	852485(Tax:4932)	Chemical	Gene	transporter|compound|START_ENTITY transporter|nsubj|END_ENTITY	Yeast Gdt1 is a Golgi-localized calcium transporter required for stress-induced calcium signaling and protein glycosylation .
27075443	0	calcium	80,87	Gdt1	6,10	calcium	Gdt1	MESH:D002118	852485(Tax:4932)	Chemical	Gene	signaling|compound|START_ENTITY required|nmod|signaling transporter|acl|required transporter|nsubj|END_ENTITY	Yeast Gdt1 is a Golgi-localized calcium transporter required for stress-induced calcium signaling and protein glycosylation .
10791895	0	calcium	60,67	Gelsolin	35,43	calcium	Gelsolin	MESH:D002118	2934	Chemical	Gene	dependence|nmod|START_ENTITY dependence|nmod:poss|END_ENTITY	Artificial_phosphorylation removes Gelsolin 's dependence on calcium .
12742020	0	calcium	87,94	Gelsolin	0,8	calcium	Gelsolin	MESH:D002118	2934	Chemical	Gene	ions|compound|START_ENTITY sites|nmod|ions domains|nmod|sites domains|nsubj|END_ENTITY	Gelsolin domains 4-6 in active , actin-free conformation identifies sites of regulatory calcium ions .
9252353	0	calcium	74,81	Gelsolin	0,8	calcium	Gelsolin	MESH:D002118	2934	Chemical	Gene	modulated|nmod|START_ENTITY bisphosphate|acl:relcl|modulated binding|dep|bisphosphate binding|advmod|END_ENTITY	Gelsolin binding to phosphatidylinositol_4 ,5 - bisphosphate is modulated by calcium and pH. The actin cytoskeleton of nonmuscle cells undergoes extensive remodeling during agonist stimulation .
20848601	0	calcium	15,22	GluK1	0,5	calcium	GluK1	MESH:D002118	2897	Chemical	Gene	release|compound|START_ENTITY inhibits|dobj|release inhibits|nsubj|END_ENTITY	GluK1 inhibits calcium dependent and independent transmitter release at associational/commissural synapses in area CA3 of the hippocampus .
10627588	0	calcium	14,21	GluR2	36,41	calcium	GluR2	MESH:D002118	29627(Tax:10116)	Chemical	Gene	permeability|compound|START_ENTITY permeability|appos|expression expression|amod|END_ENTITY	AMPA receptor calcium permeability , GluR2 expression , and selective motoneuron vulnerability .
20132465	0	calcium	79,86	GluR2	156,161	calcium	GluR2	MESH:D002118	14800(Tax:10090)	Chemical	Gene	entry|compound|START_ENTITY reduction|nmod|entry induces|dobj|reduction induces|nmod|expression expression|nmod|subunit subunit|amod|END_ENTITY	Tumour necrosis factor alpha induces rapid reduction in AMPA receptor-mediated calcium entry in motor neurones by increasing cell surface expression of the GluR2 subunit : relevance to neurodegeneration .
7789644	0	calcium	122,129	Glucagon-like_peptide_I	0,23	calcium	Glucagon-like peptide I	MESH:D002118	14526(Tax:10090)	Chemical	Gene	mobilization|compound|START_ENTITY enhancement|nmod|mobilization increases|nmod|enhancement increases|nsubj|END_ENTITY	Glucagon-like_peptide_I increases cytoplasmic calcium in insulin-secreting beta_TC3-cells by enhancement of intracellular calcium mobilization .
7789644	0	calcium	46,53	Glucagon-like_peptide_I	0,23	calcium	Glucagon-like peptide I	MESH:D002118	14526(Tax:10090)	Chemical	Gene	increases|dobj|START_ENTITY increases|nsubj|END_ENTITY	Glucagon-like_peptide_I increases cytoplasmic calcium in insulin-secreting beta_TC3-cells by enhancement of intracellular calcium mobilization .
19903011	0	calcium	27,34	Glucagon_receptor	0,17	calcium	Glucagon receptor	MESH:D002118	2642	Chemical	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	Glucagon_receptor mediates calcium signaling by coupling to G alpha q/11 and G alpha i/o in HEK293 cells .
1547730	0	calcium	145,152	GnRH	47,51	calcium	GnRH	MESH:D002118	2796	Chemical	Gene	responses|compound|START_ENTITY Maintenance|nmod|responses Maintenance|appos|END_ENTITY	Maintenance of gonadotropin-releasing_hormone -LRB- GnRH -RRB- - stimulated luteinizing hormone release despite desensitization of GnRH-stimulated cytosolic calcium responses .
20739401	0	calcium	98,105	GnRH	150,154	calcium	GnRH	MESH:D002118	14714(Tax:10090)	Chemical	Gene	currents|compound|START_ENTITY currents|nmod|neurons neurons|appos|END_ENTITY	Progesterone treatment inhibits and dihydrotestosterone -LRB- DHT -RRB- treatment potentiates voltage-gated calcium currents in gonadotropin-releasing_hormone -LRB- GnRH -RRB- neurons .
23056554	0	calcium	91,98	GnRH	31,35	calcium	GnRH	MESH:D002118	2796	Chemical	Gene	eminence|nmod|START_ENTITY extend|nmod|eminence developing|xcomp|extend developing|dobj|neurons neurons|compound|END_ENTITY	Netrin-1 stimulates developing GnRH neurons to extend neurites to the median eminence in a calcium - dependent manner .
23239819	0	calcium	72,79	GnRH	0,4	calcium	GnRH	MESH:D002118	25194(Tax:10116)	Chemical	Gene	pathways|compound|START_ENTITY gonadotropes|nmod|pathways decreases|nmod|gonadotropes decreases|nsubj|END_ENTITY	GnRH decreases adiponectin expression in pituitary gonadotropes via the calcium and PKA pathways .
23574739	0	calcium	75,82	GnRH	100,104	calcium	GnRH	MESH:D002118	613033(Tax:9544)	Chemical	Gene	concentration|compound|START_ENTITY concentration|nmod|END_ENTITY	A network model of the periodic synchronization process in the dynamics of calcium concentration in GnRH neurons .
2457798	0	calcium	167,174	GnRH	64,68	calcium	GnRH	MESH:D002118	2796	Chemical	Gene	channel|compound|START_ENTITY role|nmod|channel diminishes|parataxis|role diminishes|nsubj|Homologous Homologous|appos|END_ENTITY	Homologous desensitization with gonadotropin-releasing_hormone -LRB- GnRH -RRB- also diminishes gonadotrope responsiveness to maitotoxin : a role for the GnRH_receptor-regulated calcium ion channel in mediation of cellular desensitization .
2497454	0	calcium	11,18	GnRH	55,59	calcium	GnRH	MESH:D002118	2796	Chemical	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A role for calcium in gonadotrophin-releasing_hormone -LRB- GnRH -RRB- stimulated secretion of chorionic gonadotrophin by first trimester human placental minces in vitro .
2689778	0	calcium	50,57	GnRH	23,27	calcium	GnRH	MESH:D002118	2796	Chemical	Gene	mobilization|compound|START_ENTITY participation|nmod|mobilization Mechanism|dep|participation Mechanism|nmod|action action|nmod|END_ENTITY	Mechanism of action of GnRH : the participation of calcium mobilization and activation of protein kinase C in gonadotropin secretion .
3113921	0	calcium	95,102	GnRH	156,160	calcium	GnRH	MESH:D002118	25194(Tax:10116)	Chemical	Gene	dependency|compound|START_ENTITY vitro|dep|dependency hypothalamus|advcl|vitro hypothalamus|nmod|analogs analogs|compound|END_ENTITY	Pulsatile release of gonadotropin-releasing_hormone -LRB- GnRH -RRB- from the rat hypothalamus in vitro : calcium and glucose dependency and inhibition by superactive GnRH analogs .
3113921	0	calcium	95,102	GnRH	53,57	calcium	GnRH	MESH:D002118	25194(Tax:10116)	Chemical	Gene	dependency|compound|START_ENTITY vitro|dep|dependency hypothalamus|advcl|vitro hypothalamus|nsubj|release release|nmod|gonadotropin-releasing_hormone gonadotropin-releasing_hormone|appos|END_ENTITY	Pulsatile release of gonadotropin-releasing_hormone -LRB- GnRH -RRB- from the rat hypothalamus in vitro : calcium and glucose dependency and inhibition by superactive GnRH analogs .
16029198	0	calcium	14,21	GnRH-1	45,51	calcium	GnRH-1	MESH:D002118	14714(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY channels|nmod|END_ENTITY	Voltage-gated calcium channels in developing GnRH-1 neuronal system in the mouse .
3921069	0	calcium	112,119	Gonadotropin-releasing_hormone	0,30	calcium	Gonadotropin-releasing hormone	MESH:D002118	2796	Chemical	Gene	increase|nmod|START_ENTITY produces|dobj|increase produces|nsubj|stimulation stimulation|amod|END_ENTITY	Gonadotropin-releasing_hormone stimulation of pituitary gonadotrope cells produces an increase in intracellular calcium .
1639023	0	calcium	44,51	Growth_hormone	0,14	calcium	Growth hormone	MESH:D002118	81668(Tax:10116)	Chemical	Gene	intracellular|dobj|START_ENTITY intracellular|nsubj|increases increases|amod|END_ENTITY	Growth_hormone increases intracellular free calcium in rat adipocytes : correlation with actions on carbohydrate metabolism .
18602447	0	calcium	51,58	Growth_hormone	0,14	calcium	Growth hormone	MESH:D002118	2688	Chemical	Gene	handling|compound|START_ENTITY signaling|dep|handling signaling|compound|END_ENTITY	Growth_hormone signaling in pancreatic beta-cells -- calcium handling regulated by growth_hormone .
22493744	0	calcium	136,143	Growth_hormone	0,14	calcium	Growth hormone	MESH:D002118	14599(Tax:10090)	Chemical	Gene	regulation|nmod|START_ENTITY protect|nmod|regulation secretagogues|xcomp|protect secretagogues|nsubj|END_ENTITY	Growth_hormone secretagogues protect mouse cardiomyocytes from in vitro ischemia/reperfusion injury through regulation of intracellular calcium .
23836033	0	calcium	75,82	Growth_hormone	0,14	calcium	Growth hormone	MESH:D002118	81668(Tax:10116)	Chemical	Gene	homeostasis|compound|START_ENTITY secretagogues|nmod|homeostasis secretagogues|nsubj|END_ENTITY	Growth_hormone secretagogues exert differential effects on skeletal muscle calcium homeostasis in male rats depending on the peptidyl/nonpeptidyl structure .
2870919	0	calcium	63,70	Growth_hormone	0,14	calcium	Growth hormone	MESH:D002118	81668(Tax:10116)	Chemical	Gene	interaction|nmod|START_ENTITY release|dep|interaction release|amod|END_ENTITY	Growth_hormone release : interaction of increased extracellular calcium and somatostatin .
8137740	0	calcium	60,67	Growth_hormone	0,14	calcium	Growth hormone	MESH:D002118	81668(Tax:10116)	Chemical	Gene	absorption|compound|START_ENTITY stimulate|dobj|absorption stimulate|nsubj|hormone hormone|amod|END_ENTITY	Growth_hormone and parathyroid hormone stimulate intestinal calcium absorption in aged female rats .
8967450	0	calcium	40,47	Growth_hormone	0,14	calcium	Growth hormone	MESH:D002118	81668(Tax:10116)	Chemical	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Growth_hormone regulates cytosolic free calcium in rat fat cells by maintaining L-type calcium channels .
8967450	0	calcium	87,94	Growth_hormone	0,14	calcium	Growth hormone	MESH:D002118	81668(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY maintaining|dobj|channels regulates|advcl|maintaining regulates|nsubj|END_ENTITY	Growth_hormone regulates cytosolic free calcium in rat fat cells by maintaining L-type calcium channels .
8967451	0	calcium	25,32	Growth_hormone	0,14	calcium	Growth hormone	MESH:D002118	81668(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY uptake|amod|END_ENTITY	Growth_hormone increases calcium uptake in rat fat cells by a mechanism dependent on protein kinase C. Growth_hormone -LRB- GH ; 500 ng/ml -RRB- rapidly doubled cytosolic free Ca2 + concentration -LRB- -LSB- Ca2 + -RSB- i -RRB- in rat adipocytes as determined with the Ca2 + indicator fura_2 .
9688605	0	calcium	52,59	Growth_hormone	0,14	calcium	Growth hormone	MESH:D002118	81668(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY distribution|nmod|channels regulates|dobj|distribution regulates|nsubj|END_ENTITY	Growth_hormone regulates the distribution of L-type calcium channels in rat adipocyte membranes .
9681184	0	calcium	57,64	Growth_hormone-releasing_factor	0,31	calcium	Growth hormone-releasing factor	MESH:D002118	2691	Chemical	Gene	mobilizes|dobj|START_ENTITY mobilizes|nsubj|END_ENTITY	Growth_hormone-releasing_factor mobilizes cytosolic free calcium through different mechanisms in two somatotrope subpopulations from porcine pituitary .
16569214	0	calcium	73,80	H-Ras	58,63	calcium	H-Ras	MESH:D002118	3265	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Neuronal nitric_oxide synthase-induced S-nitrosylation of H-Ras inhibits calcium ionophore-mediated extracellular-signal-regulated kinase activity .
20633251	0	calcium	71,78	HAX1	42,46	calcium	HAX1	MESH:D002118	10456	Chemical	Gene	proteins|compound|START_ENTITY proteins|compound|END_ENTITY	Distant homologs of anti-apoptotic factor HAX1 encode parvalbumin-like calcium binding proteins .
17036211	0	calcium	14,21	HC5	63,66	calcium	HC5	MESH:D002118	122950	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|nmod|END_ENTITY	The effect of calcium and magnesium on the activity of bovicin HC5 and nisin .
21443188	0	calcium	44,51	HO-1	13,17	calcium	HO-1	MESH:D002118	3162	Chemical	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|expression expression|compound|END_ENTITY	tBHQ-induced HO-1 expression is mediated by calcium through regulation of Nrf2 binding to enhancer and polymerase II to promoter region of HO-1 .
8663271	0	calcium	34,41	HSP70	14,19	calcium	HSP70	MESH:D002118	3308	Chemical	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Inhibition of HSP70 expression by calcium ionophore A23187 in human cells .
9555982	0	calcium	18,25	IFN-gamma	0,9	calcium	IFN-gamma	MESH:D002118	3458	Chemical	Gene	transients|compound|START_ENTITY induces|dobj|transients induces|nsubj|END_ENTITY	IFN-gamma induces calcium transients and increases the capacitative calcium entry in human neutrophils .
10939336	0	calcium	27,34	IGF-1	47,52	calcium	IGF-1	MESH:D002118	16000(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY channels|nmod|END_ENTITY	Potentiation of neuronal L calcium channels by IGF-1 requires phosphorylation of the alpha1 subunit on a specific tyrosine residue .
9292730	0	calcium	24,31	IGF-1	0,5	calcium	IGF-1	MESH:D002118	3479	Chemical	Gene	channels|compound|START_ENTITY modulates|dobj|channels modulates|nsubj|END_ENTITY	IGF-1 modulates N and L calcium channels in a PI 3-kinase-dependent manner .
9147372	0	calcium	85,92	IL-1_beta	21,30	calcium	IL-1 beta	MESH:D002118	3553	Chemical	Gene	START_ENTITY|nsubj|release release|compound|END_ENTITY	beta-Amyloid-induced IL-1_beta release from an activated human monocyte cell line is calcium - and G-protein-dependent .
10500225	0	calcium	34,41	IL-1beta	0,8	calcium	IL-1beta	MESH:D002118	3553	Chemical	Gene	propagation|compound|START_ENTITY regulates|dobj|propagation regulates|nsubj|END_ENTITY	IL-1beta differentially regulates calcium wave propagation between primary human fetal astrocytes via pathways involving P2 receptors and gap junction channels .
10593617	0	calcium	33,40	IL-1beta	0,8	calcium	IL-1beta	MESH:D002118	3553	Chemical	Gene	increases|dobj|START_ENTITY increases|nsubj|END_ENTITY	IL-1beta increases intracellular calcium through an IL-1_type_1_receptor mediated mechanism in C6 astrocytic cells .
20446459	0	calcium	34,41	IL-1beta	22,30	calcium	IL-1beta	MESH:D002118	24494(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|nmod|channels	-LSB- Inhibition effect of IL-1beta on calcium channels currents in cultured cortical neurons of rat -RSB- .
1612637	0	calcium	112,119	IL-2	17,21	calcium	IL-2	MESH:D002118	3558	Chemical	Gene	ion|compound|START_ENTITY involvement|nmod|ion Up-regulation|dep|involvement Up-regulation|nmod|END_ENTITY	Up-regulation of IL-2 induced lymphokine activated killer cell activity by cisplatin and FK-565 : involvement of calcium ion .
24218893	0	calcium	69,76	IL-2	33,37	calcium	IL-2	MESH:D002118	3558	Chemical	Gene	releasing|nmod|START_ENTITY END_ENTITY|acl|releasing	-LSB- Traffic-related PM2 .5 regulates IL-2 releasing in Jurkat T cells by calcium signaling pathway -RSB- .
2965729	6	calcium	957,964	IL-2	881,885	calcium	IL-2	MESH:D002118	16183(Tax:10090)	Chemical	Gene	ionophores|compound|START_ENTITY combination|nmod|ionophores elicits|nsubj|combination showing|ccomp|elicits experiments|acl|showing supported|nmod|experiments supported|nsubjpass|presence presence|nmod|cells cells|nmod|production production|compound|END_ENTITY	The presence of precursor cells for IL-2 production is supported by experiments showing that the combination of calcium ionophores and PMA elicits IL-2 production by spleen cells from both normal and T. _ cruzi-infected mice .
3093371	0	calcium	25,32	IL-2	79,83	calcium	IL-2	MESH:D002118	16183(Tax:10090)	Chemical	Gene	ionophore|compound|START_ENTITY ionophore|nmod|interleukin-2 interleukin-2|appos|END_ENTITY	Synergistic induction by calcium ionophore and phorbol_ester of interleukin-2 -LRB- IL-2 -RRB- receptor expression , IL-2 production , and proliferation in autoimmune_MRL / MP-lpr_mice .
8912879	0	calcium	6,13	IL-2	57,61	calcium	IL-2	MESH:D002118	3558	Chemical	Gene	signaling|compound|START_ENTITY signaling|nmod|expression expression|compound|END_ENTITY	Early calcium signaling and calcium requirements for the IL-2 receptor expression and IL-2 production in stimulated lymphocytes .
9456439	7	calcium	1062,1069	IL-2	1161,1165	calcium	IL-2	MESH:D002118	3558	Chemical	Gene	improved|dobj|START_ENTITY improved|nmod|completion completion|nmod|treatment treatment|compound|END_ENTITY	TPN improved serum calcium and potassium concentrations , particularly during spontaneous diuresis after completion of IL-2 treatment .
16280365	0	calcium	14,21	IL-4	0,4	calcium	IL-4	MESH:D002118	280824(Tax:9913)	Chemical	Gene	transients|compound|START_ENTITY inhibits|dobj|transients inhibits|nsubj|END_ENTITY	IL-4 inhibits calcium transients in bovine trachealis cells by a ryanodine receptor-dependent mechanism .
17482902	0	calcium	115,122	IP3R	101,105	calcium	IP3R	MESH:D002118	3710	Chemical	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	Brain-derived_neurotrophic_factor regulates AMPA receptor trafficking to post-synaptic densities via IP3R and TRPC calcium signaling .
14581584	1	calcium	130,137	InsP3R	162,168	calcium	InsP3R	MESH:D002118	25262(Tax:10116)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|gating gating|amod|END_ENTITY	Application of allosteric modeling to calcium and InsP3 regulation of InsP3R single-channel gating .
22037186	0	calcium	120,127	InsP3R	113,119	calcium	InsP3R	MESH:D002118	16438(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Calcium homeostasis in vascular smooth muscle cells is altered in type 2 diabetes by Bcl-2 protein modulation of InsP3R calcium release channels .
168454	0	calcium	38,45	Insulin	0,7	calcium	Insulin	MESH:D002118	3630	Chemical	Gene	infusion|compound|START_ENTITY release|nmod|infusion release|nsubj|END_ENTITY	Insulin and proinsulin release during calcium infusion in a patient with islet-cell tumor .
17053293	0	calcium	40,47	Insulin	0,7	calcium	Insulin	MESH:D002118	3630	Chemical	Gene	infusion|compound|START_ENTITY responses|nmod|infusion responses|compound|END_ENTITY	Insulin responses to selective arterial calcium infusion under hyperinsulinemic euglycemic_glucose_clamps : case studies in adult_nesidioblastosis and childhood_insulinoma .
19317814	0	calcium	35,42	Insulin	0,7	calcium	Insulin	MESH:D002118	3630	Chemical	Gene	supplementation|compound|START_ENTITY increase|nmod|supplementation increase|nsubj|sensitivity sensitivity|compound|END_ENTITY	Insulin sensitivity increase after calcium supplementation and change in intraplatelet calcium and sodium-hydrogen exchange in hypertensive patients with Type 2 diabetes .
19317814	0	calcium	87,94	Insulin	0,7	calcium	Insulin	MESH:D002118	3630	Chemical	Gene	increase|nmod|START_ENTITY increase|nsubj|sensitivity sensitivity|compound|END_ENTITY	Insulin sensitivity increase after calcium supplementation and change in intraplatelet calcium and sodium-hydrogen exchange in hypertensive patients with Type 2 diabetes .
20722978	0	calcium	112,119	Insulin	0,7	calcium	Insulin	MESH:D002118	3630	Chemical	Gene	channels|compound|START_ENTITY dissociation|nmod|channels state|nmod|dissociation enter|dobj|state enter|nsubj|granules granules|compound|END_ENTITY	Insulin secretory granules enter a highly calcium-sensitive state following palmitate-induced dissociation from calcium channels : a theoretical study .
216887	0	calcium	31,38	Insulin	0,7	calcium	Insulin	MESH:D002118	3630	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|END_ENTITY	Insulin release in response to calcium in the diagnosis of insulinoma .
2553500	0	calcium	56,63	Insulin	1,8	calcium	Insulin	MESH:D002118	3630	Chemical	Gene	-RSB-|compound|START_ENTITY types|nmod|-RSB- regulation|nmod|types END_ENTITY|dep|regulation	-LSB- Insulin regulation of 2 kinetically different types of calcium current -RSB- .
7020769	0	calcium	22,29	Insulin	0,7	calcium	Insulin	MESH:D002118	3630	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Insulin inhibition of calcium binding by human placental membrane .
751809	0	calcium	29,36	Insulin	0,7	calcium	Insulin	MESH:D002118	3630	Chemical	Gene	load|compound|START_ENTITY secretion|nmod|load secretion|nsubj|END_ENTITY	Insulin secretion after oral calcium load .
8225533	0	calcium	46,53	Insulin	0,7	calcium	Insulin	MESH:D002118	3630	Chemical	Gene	concentration|compound|START_ENTITY reduces|dobj|concentration reduces|nsubj|END_ENTITY	Insulin reduces contraction and intracellular calcium concentration in vascular smooth muscle .
8319995	0	calcium	69,76	Insulin	0,7	calcium	Insulin	MESH:D002118	3630	Chemical	Gene	loads|compound|START_ENTITY vascular|nmod|loads vascular|nsubj|increases increases|compound|END_ENTITY	Insulin increases vascular smooth muscle recovery from intracellular calcium loads .
9030825	0	calcium	160,167	Insulin	0,7	calcium	Insulin	MESH:D002118	3630	Chemical	Gene	blocker|compound|START_ENTITY treatment|nmod|blocker effects|nmod|treatment investigation|nmod|effects sensitivity|dep|investigation sensitivity|compound|END_ENTITY	Insulin sensitivity , glucose effectiveness , and beta-cell function in obese males with essential hypertension : investigation of the effects of treatment with a calcium channel blocker -LRB- diltiazem -RRB- or an angiotensin-converting enzyme inhibitor -LRB- quinapril -RRB- .
16424676	0	calcium	53,60	Insulin-like_growth_factor-1	0,28	calcium	Insulin-like growth factor-1	MESH:D002118	3479	Chemical	Gene	concentration|compound|START_ENTITY increases|dobj|concentration increases|nsubj|END_ENTITY	Insulin-like_growth_factor-1 increases intracellular calcium concentration in human primary neuroendocrine pancreatic_tumor cells and a pancreatic neuroendocrine_tumor cell line -LRB- BON-1 -RRB- via R-type Ca2 + channels and regulates chromogranin_a secretion in BON-1 cells .
21956958	0	calcium	44,51	Insulin-like_growth_factor-1	0,28	calcium	Insulin-like growth factor-1	MESH:D002118	24482(Tax:10116)	Chemical	Gene	accumulation|compound|START_ENTITY increases|dobj|accumulation increases|nsubj|END_ENTITY	Insulin-like_growth_factor-1 increases bone calcium accumulation only during rapid growth in female rats .
12524443	0	calcium	71,78	Insulin_receptor_substrate_1	0,28	calcium	Insulin receptor substrate 1	MESH:D002118	100755710	Chemical	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Insulin_receptor_substrate_1 regulation of sarco-endoplasmic reticulum calcium ATPase 3 in insulin-secreting beta-cells .
12210826	0	calcium	33,40	Interferon-gamma	0,16	calcium	Interferon-gamma	MESH:D002118	3458	Chemical	Gene	influx|compound|START_ENTITY induces|dobj|influx induces|nsubj|acutely acutely|amod|END_ENTITY	Interferon-gamma acutely induces calcium influx in human microglia .
2455515	0	calcium	45,52	Interferon-gamma	0,16	calcium	Interferon-gamma	MESH:D002118	3458	Chemical	Gene	channel|compound|START_ENTITY activates|dobj|channel activates|nsubj|END_ENTITY	Interferon-gamma activates the voltage-gated calcium channel in RPMI 4788 cells .
7588238	0	calcium	41,48	Interferon-gamma	0,16	calcium	Interferon-gamma	MESH:D002118	3458	Chemical	Gene	intracellular|dobj|START_ENTITY intracellular|nsubj|increases increases|amod|END_ENTITY	Interferon-gamma increases intracellular calcium and inositol_phosphates in primary human thyroid cell culture .
7905278	0	calcium	36,43	Interferon-gamma	0,16	calcium	Interferon-gamma	MESH:D002118	3458	Chemical	Gene	concentration|compound|START_ENTITY increases|dep|concentration increases|amod|END_ENTITY	Interferon-gamma increases cellular calcium ion concentration and inositol_1 ,4,5 - trisphosphate formation in human renal_carcinoma cells : relation to ICAM-1 antigen expression .
8088386	0	calcium	42,49	Interferon-gamma	0,16	calcium	Interferon-gamma	MESH:D002118	3458	Chemical	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	Interferon-gamma modulates cytosolic free calcium in human neutrophilic granulocytes .
8937348	0	calcium	27,34	Interferon-gamma	0,16	calcium	Interferon-gamma	MESH:D002118	3458	Chemical	Gene	influx|compound|START_ENTITY influx|amod|END_ENTITY	Interferon-gamma activated calcium influx in peripheral blood lymphocytes from patients with primary and secondary progressive multiple_sclerosis .
18495501	0	calcium	43,50	Interleukin-1	0,13	calcium	Interleukin-1	MESH:D002118	3552	Chemical	Gene	signaling|compound|START_ENTITY inhibits|dobj|signaling inhibits|nsubj|END_ENTITY	Interleukin-1 inhibits osmotically induced calcium signaling and volume regulation in articular chondrocytes .
8384836	0	calcium	67,74	Interleukin-1_alpha	0,19	calcium	Interleukin-1 alpha	MESH:D002118	100009250(Tax:9986)	Chemical	Gene	increase|nmod|START_ENTITY induces|dobj|increase induces|nsubj|END_ENTITY	Interleukin-1_alpha induces a sustained increase in cytosolic free calcium in cultured rabbit osteoclasts .
8385544	0	calcium	43,50	Interleukin-1_receptor_antagonist	0,33	calcium	Interleukin-1 receptor antagonist	MESH:D002118	3557	Chemical	Gene	accumulation|compound|START_ENTITY inhibits|dobj|accumulation inhibits|nsubj|END_ENTITY	Interleukin-1_receptor_antagonist inhibits calcium accumulation in in vivo chronic granuloma induced by potassium_permanganate .
12606352	0	calcium	26,33	Interleukin-1beta	0,17	calcium	Interleukin-1beta	MESH:D002118	3553	Chemical	Gene	transients|compound|START_ENTITY induces|dobj|transients induces|nsubj|END_ENTITY	Interleukin-1beta induces calcium transients and enhances basal and store operated calcium entry in human myometrial smooth muscle .
8635696	0	calcium	64,71	Interleukin-1beta	0,17	calcium	Interleukin-1beta	MESH:D002118	24494(Tax:10116)	Chemical	Gene	current|compound|START_ENTITY enhance|dobj|current enhance|nsubj|END_ENTITY	Interleukin-1beta , tumor_necrosis_factor-alpha , and LPS enhance calcium channel current in isolated vascular smooth muscle cells of rat tail artery .
11228400	0	calcium	152,159	Interleukin-4	0,13	calcium	Interleukin-4	MESH:D002118	3565	Chemical	Gene	ion|compound|START_ENTITY involvement|nmod|ion inhibition|dep|involvement reversed|nmod|inhibition reversed|nsubj|END_ENTITY	Interleukin-4 reversed the Interleukin-1-inhibited proteoglycan synthesis through the inhibition of NO release : a possible involvement of intracellular calcium ion .
11509335	0	calcium	31,38	Interleukin-4	0,13	calcium	Interleukin-4	MESH:D002118	280824(Tax:9913)	Chemical	Gene	transients|compound|START_ENTITY inhibits|dobj|transients inhibits|nsubj|END_ENTITY	Interleukin-4 rapidly inhibits calcium transients in response to carbachol in bovine airway smooth muscle cells .
12639714	0	calcium	108,115	Interleukin-8	0,13	calcium	Interleukin-8	MESH:D002118	3576	Chemical	Gene	investigation|compound|START_ENTITY role|nmod|investigation production|dep|role production|amod|END_ENTITY	Interleukin-8 production induced by the endozepine_triakontatetraneuropeptide in human neutrophils : role of calcium and pharmacological investigation of signal transduction pathways .
1512465	0	calcium	25,32	Interleukin-8	0,13	calcium	Interleukin-8	MESH:D002118	3576	Chemical	Gene	transients|compound|START_ENTITY stimulates|dobj|transients stimulates|nsubj|END_ENTITY	Interleukin-8 stimulates calcium transients and promotes epidermal cell proliferation .
15862344	0	calcium	91,98	Interleukin-8	0,13	calcium	Interleukin-8	MESH:D002118	3576	Chemical	Gene	changes|nmod|START_ENTITY oxidative|nmod|changes oxidative|nsubj|primes primes|amod|END_ENTITY	Interleukin-8 primes oxidative burst in neutrophil-like HL-60 through changes in cytosolic calcium .
9766632	0	calcium	87,94	Interleukin-8	0,13	calcium	Interleukin-8	MESH:D002118	3576	Chemical	Gene	fluxes|compound|START_ENTITY associated|nmod|fluxes associated|nsubjpass|priming priming|amod|END_ENTITY	Interleukin-8 priming of human neutrophils is not associated with persistently altered calcium fluxes but is additive with lipopolysaccharide .
21744336	0	calcium	120,127	Involucrin	0,10	calcium	Involucrin	MESH:D002118	60583(Tax:10116)	Chemical	Gene	stimulation|compound|START_ENTITY downregulated|nmod|stimulation downregulated|ccomp|END_ENTITY	Involucrin , but not filaggrin and Kdap mRNA , expression is downregulated in 3-D cultures of intact rat hair bulbs after calcium stimulation .
17417640	0	calcium	82,89	Itpkb	52,57	calcium	Itpkb	MESH:D002118	320404(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Production of Ins -LRB- 1,3,4,5 -RRB- P4 mediated by the kinase Itpkb inhibits store-operated calcium channels and regulates B cell selection and activation .
20090765	0	calcium	99,106	Kallikrein	0,10	calcium	Kallikrein	MESH:D002118	9622	Chemical	Gene	controlled|nmod|START_ENTITY controlled|nsubjpass|expression expression|compound|END_ENTITY	Kallikrein expression and cathelicidin processing are independently controlled in keratinocytes by calcium , vitamin_D -LRB- 3 -RRB- , and retinoic_acid .
21442474	0	calcium	29,36	Klotho	0,6	calcium	Klotho	MESH:D002118	9365	Chemical	Gene	homeostasis|compound|START_ENTITY regulator|nmod|homeostasis END_ENTITY|dep|regulator	Klotho : a novel regulator of calcium and phosphorus homeostasis .
9087605	0	calcium	54,61	L-selectin	0,10	calcium	L-selectin	MESH:D002118	6402	Chemical	Gene	stimulation|nmod|START_ENTITY stimulation|amod|END_ENTITY	L-selectin stimulation of canine neutrophil initiates calcium signal secondary to tyrosine kinase activation .
22442089	0	calcium	51,58	LIM_domain_only_4	0,17	calcium	LIM domain only 4	MESH:D002118	16911(Tax:10090)	Chemical	Gene	release|compound|START_ENTITY regulates|dobj|release regulates|nsubj|END_ENTITY	LIM_domain_only_4 -LRB- LMO4 -RRB- regulates calcium-induced calcium release and synaptic plasticity in the hippocampus .
11016955	0	calcium	58,65	LRP	31,34	calcium	LRP	MESH:D002118	4035	Chemical	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	The endocytic receptor protein LRP also mediates neuronal calcium signaling via N-methyl-D-aspartate receptors .
22441017	0	calcium	34,41	LRRK2	0,5	calcium	LRRK2	MESH:D002118	120892	Chemical	Gene	modulator|nmod|START_ENTITY END_ENTITY|nmod|modulator	LRRK2 as a modulator of lysosomal calcium homeostasis with downstream effects on autophagy .
24815697	0	calcium	30,37	MCU	57,60	calcium	MCU	MESH:D002118	90550	Chemical	Gene	uptake|compound|START_ENTITY modulates|dobj|uptake modulates|nmod|END_ENTITY	ERp57 modulates mitochondrial calcium uptake through the MCU .
23728952	0	calcium	28,35	MLCK	62,66	calcium	MLCK	MESH:D002118	291926(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY release|nmod|END_ENTITY	Dietary selenium influences calcium release and activation of MLCK in uterine smooth muscle of rats .
20332274	0	calcium	11,18	MLH1	36,40	calcium	MLH1	MESH:D002118	4292	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of calcium and vitamin_D on MLH1 and MSH2 expression in rectal mucosa of sporadic colorectal_adenoma patients .
9706399	0	calcium	104,111	MRP14	90,95	calcium	MRP14	MESH:D002118	6280	Chemical	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Transcriptional regulation by C/EBP _ alpha and - beta in the expression of the gene for the MRP14 myeloid calcium binding protein .
18451174	0	calcium	43,50	MS4A12	0,6	calcium	MS4A12	MESH:D002118	381213(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY channel|nsubj|END_ENTITY	MS4A12 is a colon-selective store-operated calcium channel promoting malignant cell processes .
7597704	0	calcium	84,91	Melittin	0,8	calcium	Melittin	MESH:D002118	406130(Tax:7460)	Chemical	Gene	overload|compound|START_ENTITY cardiotoxicity|nmod|overload cardiotoxicity|nsubj|END_ENTITY	Melittin cardiotoxicity in cultured mouse cardiac myocytes and its correlation with calcium overload .
19762439	0	calcium	47,54	Mid1	12,16	calcium	Mid1	MESH:D002118	855425(Tax:4932)	Chemical	Gene	channel|compound|START_ENTITY Deletion|appos|channel Deletion|nmod|END_ENTITY	Deletion of Mid1 , a putative stretch-activated calcium channel in Claviceps purpurea , affects vegetative growth , cell wall synthesis and virulence .
21357477	0	calcium	25,32	Mid1	0,4	calcium	Mid1	MESH:D002118	855425(Tax:4932)	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|appos|channel	Mid1 , a mechanosensitive calcium ion channel , affects growth , development , and ascospore discharge in the filamentous fungus Gibberella_zeae .
23175710	0	calcium	16,23	Mid1	93,97	calcium	Mid1	MESH:D002118	4281	Chemical	Gene	channel|compound|START_ENTITY Activity|nmod|channel pore|nsubj|Activity pore|ccomp|dependent dependent|nmod|region region|nmod|END_ENTITY	Activity of the calcium channel pore Cch1 is dependent on a modulatory region of the subunit Mid1 in Cryptococcus_neoformans .
19249275	0	calcium	11,18	Miro1	0,5	calcium	Miro1	MESH:D002118	55288	Chemical	Gene	sensor|compound|START_ENTITY sensor|nsubj|END_ENTITY	Miro1 is a calcium sensor for glutamate receptor-dependent localization of mitochondria at synapses .
9277420	0	calcium	33,40	Motilin	0,7	calcium	Motilin	MESH:D002118	4295	Chemical	Gene	current|compound|START_ENTITY activate|dobj|current activate|nsubj|END_ENTITY	Motilin and OHM-11526 activate a calcium current in human and canine jejunal circular smooth muscle .
21245134	0	calcium	30,37	Mucolipin-3	0,11	calcium	Mucolipin-3	MESH:D002118	171166(Tax:10090)	Chemical	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Mucolipin-3 regulates luminal calcium , acidification , and membrane fusion in the endosomal pathway .
22061127	0	calcium	98,105	Myosin	0,6	calcium	Myosin	MESH:D002118	79784	Chemical	Gene	activity|nmod|START_ENTITY influence|dobj|activity influence|nsubj|isoforms isoforms|amod|END_ENTITY	Myosin heavy chain isoforms influence myofibrillar ATPase activity under simulated postmortem pH , calcium , and temperature conditions .
15007063	0	calcium	24,31	Myosin_V	0,8	calcium	Myosin V	MESH:D002118	4644	Chemical	Gene	regulation|nmod|START_ENTITY END_ENTITY|dep|regulation	Myosin_V : regulation by calcium , calmodulin , and the tail domain .
15163556	0	calcium	210,217	NADPH	148,153	calcium	beta2	MESH:D002118	10242	Chemical	Gene	influx|compound|START_ENTITY activation|nmod|influx oxidase|dobj|activation oxidase|nsubj|Prevention Prevention|nmod|Mac-1 Mac-1|dep|firm firm|acl|adhesion adhesion|nmod|impairment impairment|nmod|END_ENTITY	Prevention of macrophage_adhesion_molecule-1 -LRB- Mac-1 -RRB- - dependent neutrophil firm adhesion by taxifolin through impairment of protein kinase-dependent NADPH oxidase activation and antagonism of G protein-mediated calcium influx .
2441031	0	calcium	135,142	NADPH	12,17	calcium	NADPH	MESH:D002118	1666	Chemical	Gene	pump|compound|START_ENTITY modulation|nmod|pump enzymes|nmod|modulation enzymes|amod|END_ENTITY	The role of NADPH - and reduced_glutathione-dependent enzymes in the norepinephrine modulation of the ATP-dependent , hepatic microsomal calcium pump : a new pathway for the noradrenergic regulation of cytosolic calcium in the hepatocyte .
2441031	0	calcium	209,216	NADPH	12,17	calcium	NADPH	MESH:D002118	1666	Chemical	Gene	regulation|nmod|START_ENTITY pathway|nmod|regulation role|dep|pathway role|nmod|enzymes enzymes|amod|END_ENTITY	The role of NADPH - and reduced_glutathione-dependent enzymes in the norepinephrine modulation of the ATP-dependent , hepatic microsomal calcium pump : a new pathway for the noradrenergic regulation of cytosolic calcium in the hepatocyte .
25275601	0	calcium	28,35	NADPH	85,90	calcium	NADPH	MESH:D002118	1666	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Seizure activity results in calcium - and mitochondria-independent ROS production via NADPH and xanthine oxidase activation .
20648216	0	calcium	42,49	NADPH_oxidase_5	68,83	calcium	NADPH oxidase 5	MESH:D002118	79400	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Conformational States and kinetics of the calcium binding domain of NADPH_oxidase_5 .
15336574	0	calcium	43,50	NCS-1	67,72	calcium	NCS-1	MESH:D002118	23413	Chemical	Gene	proteins|compound|START_ENTITY proteins|amod|END_ENTITY	MGluRs regulate the expression of neuronal calcium sensor proteins NCS-1 and VILIP-1 and the immediate early gene arg3 .1 / arc in the hippocampus in vivo .
15611992	0	calcium	27,34	NCS-1	50,55	calcium	NCS-1	MESH:D002118	14299(Tax:10090)	Chemical	Gene	Expression|nmod|START_ENTITY sensor|nsubj|Expression sensor|dobj|END_ENTITY	Expression of the neuronal calcium sensor protein NCS-1 in the developing mouse olfactory pathway .
19732951	0	calcium	81,88	NCS-1	51,56	calcium	NCS-1	MESH:D002118	23413	Chemical	Gene	START_ENTITY|nsubj|proteolysis proteolysis|nmod|END_ENTITY	Discrete proteolysis of neuronal_calcium_sensor-1 -LRB- NCS-1 -RRB- by mu-calpain disrupts calcium binding .
20801127	0	calcium	35,42	NCS-1	94,99	calcium	NCS-1	MESH:D002118	65153(Tax:10116)	Chemical	Gene	oscillations|compound|START_ENTITY accelerates|dobj|oscillations accelerates|advcl|interacting interacting|nmod|END_ENTITY	Paclitaxel accelerates spontaneous calcium oscillations in cardiomyocytes by interacting with NCS-1 and the InsP3R .
11479282	0	calcium	9,16	NF-kappa_B	50,60	calcium	NF-kappa B	MESH:D002118	4790	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Elevated calcium in preneoplastic cells activates NF-kappa_B and confers resistance to apoptosis .
12665571	0	calcium	5,12	NF-kappa_B	16,26	calcium	NF-kappa B	MESH:D002118	4790	Chemical	Gene	pathways|nmod|START_ENTITY pathways|csubj|END_ENTITY	From calcium to NF-kappa_B signaling pathways in neurons .
17785810	0	calcium	99,106	NFAT1	11,16	calcium	NFAT1	MESH:D002118	18019(Tax:10090)	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Reciprocal NFAT1 and NFAT2 nuclear localization in CD8 + anergic T cells is regulated by suboptimal calcium signaling .
21325277	0	calcium	58,65	NFAT1	49,54	calcium	NFAT1	MESH:D002118	4773	Chemical	Gene	microdomains|compound|START_ENTITY END_ENTITY|nmod|microdomains	Selective activation of the transcription factor NFAT1 by calcium microdomains near Ca2 + release-activated Ca2 + -LRB- CRAC -RRB- channels .
9112013	0	calcium	53,60	NIT-1	97,102	calcium	NIT-1	MESH:D002118	27045(Tax:10090)	Chemical	Gene	concentration|compound|START_ENTITY concentration|nmod|END_ENTITY	Mechanisms of arginine-induced increase in cytosolic calcium concentration in the beta-cell line NIT-1 .
17478539	0	calcium	48,55	NKCC1	39,44	calcium	NKCC1	MESH:D002118	6558	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Dynamic and differential regulation of NKCC1 by calcium and cAMP in the native human colonic epithelium .
8395583	0	calcium	105,112	NPY-1	46,51	calcium	NPY-1	MESH:D002118	29358(Tax:10116)	Chemical	Gene	currents|compound|START_ENTITY actions|nmod|currents have|dobj|actions have|nsubj|Agonists Agonists|nmod|subtypes subtypes|amod|END_ENTITY	Agonists for neuropeptide_Y receptor subtypes NPY-1 and NPY-2 have opposite actions on rat nodose neuron calcium currents .
17302911	0	calcium	10,17	NSF	0,3	calcium	NSF	MESH:D002118	4905	Chemical	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	NSF binds calcium to regulate its interaction with AMPA receptor subunit GluR2 .
9108087	0	calcium	55,62	NSP4	26,30	calcium	NSP4	MESH:D002118	400668	Chemical	Gene	mobilizes|dobj|START_ENTITY mobilizes|nsubj|END_ENTITY	The rotavirus enterotoxin NSP4 mobilizes intracellular calcium in human intestinal cells by stimulating phospholipase C-mediated inositol_1 ,4,5 - trisphosphate production .
2920032	0	calcium	21,28	Na-Ca_exchanger	0,15	calcium	Na-Ca exchanger	MESH:D002118	6546	Chemical	Gene	pathway|compound|START_ENTITY END_ENTITY|nmod|pathway	Na-Ca_exchanger as a calcium influx pathway in adrenal glomerulosa cells .
10051773	0	calcium	39,46	Neuropeptide_Y	0,14	calcium	Neuropeptide Y	MESH:D002118	24604(Tax:10116)	Chemical	Gene	increases|dobj|START_ENTITY increases|nsubj|END_ENTITY	Neuropeptide_Y increases intracellular calcium in rat pinealocytes .
10780975	0	calcium	39,46	Neuropeptide_Y	0,14	calcium	Neuropeptide Y	MESH:D002118	24604(Tax:10116)	Chemical	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Neuropeptide_Y regulates intracellular calcium through different signalling pathways linked to a Y -LRB- 1 -RRB- - receptor in rat mesenteric small arteries .
22613697	0	calcium	25,32	Neuropeptide_Y	0,14	calcium	Neuropeptide Y	MESH:D002118	4852	Chemical	Gene	channels|compound|START_ENTITY modulates|dobj|channels modulates|nsubj|END_ENTITY	Neuropeptide_Y modulates calcium channels in hamster submandibular ganglion neurons .
2358888	0	calcium	23,30	Neuropeptide_Y	0,14	calcium	Neuropeptide Y	MESH:D002118	24604(Tax:10116)	Chemical	Gene	current|nmod:npmod|START_ENTITY reduces|dobj|current reduces|nsubj|END_ENTITY	Neuropeptide_Y reduces calcium current and inhibits acetylcholine release in nodose neurons via a pertussis toxin-sensitive mechanism .
2458269	0	calcium	24,31	Neuropeptide_Y	0,14	calcium	Neuropeptide Y	MESH:D002118	4852	Chemical	Gene	current|compound|START_ENTITY blocks|dobj|current blocks|advmod|END_ENTITY	Neuropeptide_Y blocks a calcium current in C cells of bullfrog sympathetic ganglia .
8098766	0	calcium	49,56	Neuropeptide_Y	0,14	calcium	Neuropeptide Y	MESH:D002118	24604(Tax:10116)	Chemical	Gene	currents|compound|START_ENTITY rat|nsubj|currents reduce|ccomp|rat reduce|nsubj|polypeptide polypeptide|amod|END_ENTITY	Neuropeptide_Y and pancreatic polypeptide reduce calcium currents in acutely dissociated neurons from adult rat superior cervical ganglia .
8593806	0	calcium	152,159	Neuropeptide_Y	0,14	calcium	Neuropeptide Y	MESH:D002118	24604(Tax:10116)	Chemical	Gene	dopamine|nmod|START_ENTITY entry|amod|dopamine interactions|nmod|entry evidence|nmod|interactions secretion|dep|evidence secretion|amod|suppresses suppresses|advmod|END_ENTITY	Neuropeptide_Y suppresses prolactin secretion from rat anterior pituitary cells : evidence for interactions with dopamine through inhibitory coupling to calcium entry .
8627385	0	calcium	121,128	Neuropeptide_Y	0,14	calcium	Neuropeptide Y	MESH:D002118	4852	Chemical	Gene	depression|compound|START_ENTITY form|nmod|depression depresses|parataxis|form depresses|nsubj|END_ENTITY	Neuropeptide_Y depresses GABA-mediated calcium transients in developing suprachiasmatic_nucleus neurons : a novel form of calcium long-term depression .
8627385	0	calcium	39,46	Neuropeptide_Y	0,14	calcium	Neuropeptide Y	MESH:D002118	4852	Chemical	Gene	transients|compound|START_ENTITY depresses|dobj|transients depresses|nsubj|END_ENTITY	Neuropeptide_Y depresses GABA-mediated calcium transients in developing suprachiasmatic_nucleus neurons : a novel form of calcium long-term depression .
9020878	0	calcium	59,66	Neuropeptide_Y	0,14	calcium	Neuropeptide Y	MESH:D002118	4852	Chemical	Gene	increases|nmod|START_ENTITY increases|amod|modulates modulates|advmod|END_ENTITY	Neuropeptide_Y modulates ATP-induced increases in internal calcium via the adenylate cyclase/protein kinase A system in a human neuroblastoma cell line .
9612216	0	calcium	29,36	Neuropeptide_Y	0,14	calcium	Neuropeptide Y	MESH:D002118	24604(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY inhibition|nmod|channels inhibition|amod|END_ENTITY	Neuropeptide_Y inhibition of calcium channels in PC-12 pheochromocytoma cells .
10799761	0	calcium	36,43	Neurotensin	0,11	calcium	Neurotensin	MESH:D002118	299757(Tax:10116)	Chemical	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Neurotensin regulates intracellular calcium in ventral tegmental area astrocytes : evidence for the involvement of multiple receptors .
14500581	0	calcium	28,35	Neurotensin	0,11	calcium	Neurotensin	MESH:D002118	4922	Chemical	Gene	mobilization|compound|START_ENTITY stimulates|dobj|mobilization stimulates|nsubj|END_ENTITY	Neurotensin stimulates both calcium mobilization from inositol_trisphosphate-sensitive intracellular stores and calcium influx through membrane channels in frog pituitary melanotrophs .
16838364	0	calcium	30,37	Neurotensin	0,11	calcium	Neurotensin	MESH:D002118	299757(Tax:10116)	Chemical	Gene	currents|compound|START_ENTITY effects|nmod|currents effects|compound|END_ENTITY	Neurotensin effects on N-type calcium currents among rat pallidal neurons : an electrophysiological and immunohistochemical study .
1849803	0	calcium	51,58	Neurotensin	0,11	calcium	Neurotensin	MESH:D002118	299757(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY elevate|dobj|concentration elevate|nsubj|END_ENTITY	Neurotensin and neuromedin_N elevate the cytosolic calcium concentration via transiently appearing neurotensin binding sites in cultured rat cortex cells .
2414815	0	calcium	22,29	Neurotensin	0,11	calcium	Neurotensin	MESH:D002118	299757(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY effect|nmod|transport effect|compound|END_ENTITY	Neurotensin effect on calcium transport and dopamine release in rat striatum .
2559720	0	calcium	55,62	Neurotensin	0,11	calcium	Neurotensin	MESH:D002118	4922	Chemical	Gene	mobilization|compound|START_ENTITY stimulates|dobj|mobilization stimulates|nsubj|END_ENTITY	Neurotensin stimulates inositol_trisphosphate-mediated calcium mobilization but not protein_kinase_C activation in HT29 cells .
2560176	0	calcium	31,38	Neurotensin	0,11	calcium	Neurotensin	MESH:D002118	4922	Chemical	Gene	elevates|dobj|START_ENTITY elevates|nsubj|END_ENTITY	Neurotensin elevates cytosolic calcium in small_cell_lung_cancer cells .
8737282	0	calcium	20,27	Neurotensin	0,11	calcium	Neurotensin	MESH:D002118	417883(Tax:9031)	Chemical	Gene	oscillations|compound|START_ENTITY induces|dobj|oscillations induces|nsubj|END_ENTITY	Neurotensin induces calcium oscillations in cultured amacrine cells .
8626576	0	calcium	39,46	Neurotrophin-3	0,14	calcium	Neurotrophin-3	MESH:D002118	81737(Tax:10116)	Chemical	Gene	increases|dobj|START_ENTITY increases|nsubj|END_ENTITY	Neurotrophin-3 increases intracellular calcium in a rat insulin-secreting cell line through its action on a functional TrkC receptor .
21892923	0	calcium	61,68	Neurotrophin-4	0,14	calcium	Neurotrophin-4	MESH:D002118	78405(Tax:10090)	Chemical	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	Neurotrophin-4 modulates the mechanotransducer Cav3 .2 T-type calcium current in mice down-hair neurons .
26486271	0	calcium	52,59	Nur77	24,29	calcium	Nur77	MESH:D002118	15370(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY affects|dobj|homeostasis affects|nsubj|END_ENTITY	Orphan nuclear receptor Nur77 affects cardiomyocyte calcium homeostasis and adverse cardiac remodelling .
15775404	0	calcium	16,23	OPG	9,12	calcium	OPG	MESH:D002118	4982	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	-LSB- Role of OPG in calcium metabolism -RSB- .
20103768	0	calcium	64,71	ORAI1	123,128	calcium	ORAI1	MESH:D002118	84876	Chemical	Gene	mobilization|compound|START_ENTITY mobilization|acl|associated associated|nmod|expression expression|nmod|END_ENTITY	Pivotal Advance : Nonfunctional lung effectors exhibit decreased calcium mobilization associated with reduced expression of ORAI1 .
20194792	0	calcium	46,53	ORAI1	25,30	calcium	ORAI1	MESH:D002118	84876	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Pore architecture of the ORAI1 store-operated calcium channel .
21420116	0	calcium	79,86	ORAI1	22,27	calcium	ORAI1	MESH:D002118	84876	Chemical	Gene	nephrolithiasis|compound|START_ENTITY risk|nmod|nephrolithiasis associated|nmod|risk associated|nsubjpass|polymorphism polymorphism|nmod|gene gene|compound|END_ENTITY	A polymorphism of the ORAI1 gene is associated with the risk and recurrence of calcium nephrolithiasis .
23348584	0	calcium	55,62	ORAI1	28,33	calcium	ORAI1	MESH:D002118	109305(Tax:10090)	Chemical	Gene	influx|compound|START_ENTITY influx|amod|detrimental detrimental|nmod:npmod|mediates mediates|nummod|END_ENTITY	The plasma membrane channel ORAI1 mediates detrimental calcium influx caused by endogenous oxidative stress .
24277812	0	calcium	6,13	ORAI1	0,5	calcium	ORAI1	MESH:D002118	84876	Chemical	Gene	channel|compound|START_ENTITY channel|nummod|END_ENTITY	ORAI1 calcium channel orchestrates skin homeostasis .
16766533	0	calcium	43,50	Orai1	0,5	calcium	Orai1	MESH:D002118	304496(Tax:10116)	Chemical	Gene	function|compound|START_ENTITY reconstitute|dobj|function reconstitute|nsubj|END_ENTITY	Orai1 and STIM reconstitute store-operated calcium channel function .
16807233	0	calcium	110,117	Orai1	72,77	calcium	Orai1	MESH:D002118	84876	Chemical	Gene	sensor|compound|START_ENTITY selective|nmod|sensor selective|nmod|co-expression co-expression|nmod|END_ENTITY	Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor , Stim1 .
16807233	0	calcium	21,28	Orai1	72,77	calcium	Orai1	MESH:D002118	84876	Chemical	Gene	selective|nsubj|START_ENTITY selective|nmod|co-expression co-expression|nmod|END_ENTITY	Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor , Stim1 .
17452328	0	calcium	71,78	Orai1	47,52	calcium	Orai1	MESH:D002118	84876	Chemical	Gene	START_ENTITY|nsubj|inhibition inhibition|nmod|END_ENTITY	Calcium inhibition and calcium potentiation of Orai1 , Orai2 , and Orai3 calcium release-activated calcium channels .
17452328	0	calcium	97,104	Orai1	47,52	calcium	Orai1	MESH:D002118	84876	Chemical	Gene	channels|compound|START_ENTITY calcium|dobj|channels calcium|nsubj|inhibition inhibition|nmod|END_ENTITY	Calcium inhibition and calcium potentiation of Orai1 , Orai2 , and Orai3 calcium release-activated calcium channels .
18952890	0	calcium	39,46	Orai1	17,22	calcium	Orai1	MESH:D002118	109305(Tax:10090)	Chemical	Gene	influx|compound|START_ENTITY causes|dobj|influx causes|nsubj|mutation mutation|nmod|END_ENTITY	R93W mutation in Orai1 causes impaired calcium influx in platelets .
19965684	0	calcium	30,37	Orai1	0,5	calcium	Orai1	MESH:D002118	84876	Chemical	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Orai1 regulates intracellular calcium , arrest , and shape polarization during neutrophil recruitment in shear flow .
20395295	0	calcium	30,37	Orai1	102,107	calcium	Orai1	MESH:D002118	84876	Chemical	Gene	channel|compound|START_ENTITY channel|dep|requirement requirement|nmod|Orai3 Orai3|nmod|END_ENTITY	A novel native store-operated calcium channel encoded by Orai3 : selective requirement of Orai3 versus Orai1 in estrogen receptor-positive versus estrogen receptor-negative breast_cancer cells .
22031864	0	calcium	76,83	Orai1	124,129	calcium	Orai1	MESH:D002118	84876	Chemical	Gene	signaling|compound|START_ENTITY influences|dobj|signaling influences|nmod|regulation regulation|nmod|expression expression|amod|END_ENTITY	The serum - _ and_glucocorticoid-inducible_kinase_1 -LRB- SGK1 -RRB- influences platelet calcium signaling and function by regulation of Orai1 expression in megakaryocytes .
22402985	0	calcium	6,13	Orai1	0,5	calcium	Orai1	MESH:D002118	84876	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Orai1 calcium channels in the vasculature .
22546867	0	calcium	23,30	Orai1	39,44	calcium	Orai1	MESH:D002118	109305(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY disruption|nmod|channel results|nsubj|disruption results|amod|END_ENTITY	Gene disruption of the calcium channel Orai1 results in inhibition of osteoclast and osteoblast differentiation and impairs skeletal development .
22556336	0	calcium	48,55	Orai1	80,85	calcium	Orai1	MESH:D002118	84876	Chemical	Gene	maintains|dobj|START_ENTITY maintains|nmod|mechanism mechanism|amod|END_ENTITY	Platelet-derived growth factor maintains stored calcium through a nonclustering Orai1 mechanism but evokes clustering if the endoplasmic reticulum is stressed by store depletion .
23307288	0	calcium	45,52	Orai1	27,32	calcium	Orai1	MESH:D002118	84876	Chemical	Gene	mobilization|compound|START_ENTITY regulate|dobj|mobilization interacts|xcomp|regulate interacts|nmod|END_ENTITY	Ubiquilin_1 interacts with Orai1 to regulate calcium mobilization .
24135962	0	calcium	4,11	Orai1	46,51	calcium	Orai1	MESH:D002118	109305(Tax:10090)	Chemical	Gene	release-activated|nsubj|START_ENTITY release-activated|ccomp|represents represents|nsubj|END_ENTITY	The calcium release-activated calcium channel Orai1 represents a crucial component in hypertrophic_compensation and the development of dilated_cardiomyopathy .
24321771	0	calcium	49,56	Orai1	4,9	calcium	Orai1	MESH:D002118	84876	Chemical	Gene	influx|compound|START_ENTITY important|nmod|influx important|nsubj|END_ENTITY	Are Orai1 and Orai3 channels more important than calcium influx for cell proliferation ?
24376610	0	calcium	41,48	Orai1	35,40	calcium	Orai1	MESH:D002118	109305(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Antibody-mediated targeting of the Orai1 calcium channel inhibits T cell function .
25428882	0	calcium	48,55	Orai1	86,91	calcium	Orai1	MESH:D002118	84876	Chemical	Gene	channels|compound|START_ENTITY entry|nmod|channels entry|dep|regulation regulation|nmod|END_ENTITY	Sodium entry through endothelial store-operated calcium entry channels : regulation by Orai1 .
25490950	0	calcium	67,74	Orai1	0,5	calcium	Orai1	MESH:D002118	84876	Chemical	Gene	channels|compound|START_ENTITY release-activated|dobj|channels release-activated|nsubj|expression expression|amod|END_ENTITY	Orai1 protein expression and the role of calcium release-activated calcium channels in the contraction of human term-pregnant and non-pregnant myometrium .
25490950	0	calcium	67,74	Orai1	0,5	calcium	Orai1	MESH:D002118	84876	Chemical	Gene	channels|compound|START_ENTITY release-activated|dobj|channels release-activated|nsubj|expression expression|amod|END_ENTITY	Orai1 protein expression and the role of calcium release-activated calcium channels in the contraction of human term-pregnant and non-pregnant myometrium .
25902527	0	calcium	39,46	Orai1	18,23	calcium	Orai1	MESH:D002118	109305(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Essential role of Orai1 store-operated calcium channels in lactation .
26712003	0	calcium	111,118	Orai1	71,76	calcium	Orai1	MESH:D002118	84876	Chemical	Gene	influx|compound|START_ENTITY gating|nmod|influx END_ENTITY|acl|gating	Genetically targeted single-channel optical recording reveals multiple Orai1 gating states and oscillations in calcium influx .
14525906	0	calcium	110,117	Osteoprotegerin	0,15	calcium	Osteoprotegerin	MESH:D002118	18383(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY regulated|nmod|channel regulated|nsubjpass|expression expression|compound|END_ENTITY	Osteoprotegerin expression and secretion are regulated by calcium influx through the L-type voltage-sensitive calcium channel .
14525906	0	calcium	58,65	Osteoprotegerin	0,15	calcium	Osteoprotegerin	MESH:D002118	18383(Tax:10090)	Chemical	Gene	influx|compound|START_ENTITY regulated|nmod|influx regulated|nsubjpass|expression expression|compound|END_ENTITY	Osteoprotegerin expression and secretion are regulated by calcium influx through the L-type voltage-sensitive calcium channel .
25461399	0	calcium	68,75	Osteoprotegerin	0,15	calcium	Osteoprotegerin	MESH:D002118	18383(Tax:10090)	Chemical	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Osteoprotegerin induces podosome disassembly in osteoclasts through calcium , ERK , and p38 MAPK signaling pathways .
20921140	0	calcium	15,22	Otoferlin	0,9	calcium	Otoferlin	MESH:D002118	9381	Chemical	Gene	sensor|compound|START_ENTITY sensor|nsubj|END_ENTITY	Otoferlin is a calcium sensor that directly regulates SNARE-mediated membrane fusion .
10461679	0	calcium	54,61	Oxytocin	0,8	calcium	Oxytocin	MESH:D002118	5020	Chemical	Gene	induce|nmod|START_ENTITY induce|nsubj|END_ENTITY	Oxytocin does not induce a rise in intracellular free calcium in human breast_cancer cells .
17127323	0	calcium	58,65	Oxytocin	0,8	calcium	Oxytocin	MESH:D002118	5020	Chemical	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Oxytocin and parturition : a role for increased myometrial calcium and calcium sensitization ?
20352154	0	calcium	60,67	P-glycoprotein	34,48	calcium	P-glycoprotein	MESH:D002118	5243	Chemical	Gene	blockers|compound|START_ENTITY blockers|amod|END_ENTITY	The use of amlodipine , but not of P-glycoprotein inhibiting calcium channel blockers is associated with clopidogrel poor-response .
9347117	0	calcium	132,139	P2U	85,88	calcium	P2U	MESH:D002118	5029	Chemical	Gene	mobilization|compound|START_ENTITY mobilization|compound|END_ENTITY	A calcium channel in human submandibular duct cell line , HSG cells , not regulated by P2U purinergic receptor-mediated intracellular calcium mobilization .
11127979	0	calcium	15,22	P2X1	32,36	calcium	P2X1	MESH:D002118	25505(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|dep|END_ENTITY	The purinergic calcium channels P2X1 ,2,5,7 are down-regulated while P2X3 ,4,6 are up-regulated during apoptosis in the ageing rat prostate .
15068972	0	calcium	26,33	P2X_and_P2Y_purinoceptors	75,100	calcium	P2X and P2Y purinoceptors	MESH:D002118	18436(Tax:10090)	Chemical	Gene	requires|nsubj|START_ENTITY requires|dobj|END_ENTITY	Extracellular ATP-induced calcium signaling in mIMCD-3 cells requires both P2X_and_P2Y_purinoceptors .
11193866	0	calcium	42,49	PACAP	0,5	calcium	PACAP	MESH:D002118	11516(Tax:10090)	Chemical	Gene	induce|nmod|START_ENTITY induce|nsubj|END_ENTITY	PACAP and VIP induce changes in cytosolic calcium in putative folliculostellate cells of the mouse pituitary .
1336985	6	calcium	800,807	PAF	842,845	calcium	PAF	MESH:D002118	9768	Chemical	Gene	transient|compound|START_ENTITY transient|acl|induced induced|nmod|doses doses|nmod|END_ENTITY	100 microM Verapamil was able to completely abolish the calcium transient induced by low doses of PAF .
2562430	0	calcium	35,42	PAF	166,169	calcium	PAF	MESH:D002118	9768	Chemical	Gene	mobilization|compound|START_ENTITY Measurement|nmod|mobilization activated|nsubj|Measurement activated|nmod|platelet_activating_factor platelet_activating_factor|appos|END_ENTITY	Measurement of ionized cytoplasmic calcium mobilization with the photoprotein aequorin in human polymorphonuclear leukocytes activated by platelet_activating_factor -LRB- PAF -RRB- .
2740622	0	calcium	61,68	PAF	38,41	calcium	PAF	MESH:D002118	9768	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of platelet-activating factor -LRB- PAF -RRB- on cytosolic free calcium in human peripheral blood mononuclear leukocytes .
10535908	7	calcium	1181,1188	PAR-1	1175,1180	calcium	PAR-2	MESH:D002118	2150	Chemical	Gene	mobilization|compound|START_ENTITY mobilization|compound|END_ENTITY	It binds to PAR-1 , interferes with PAR-1 calcium mobilization and cellular function -LRB- platelet_aggregation ; cell proliferation -RRB- , and has no effect on PAR-2 , PAR-3 , or PAR-4 .
17341135	0	calcium	67,74	PLC	103,106	calcium	PLC	MESH:D002118	3339	Chemical	Gene	release|compound|START_ENTITY release|nmod|END_ENTITY	Expanding the neuron 's calcium signaling repertoire : intracellular calcium release via voltage-induced PLC and IP3R activation .
10838164	0	calcium	37,44	PLD1	20,24	calcium	PLD1	MESH:D002118	5337	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of human PLD1 and PLD2 by calcium and protein_kinase_C .
20083513	1	calcium	245,252	PMCA2	261,266	calcium	PMCA2	MESH:D002118	11941(Tax:10090)	Chemical	Gene	ATPase|compound|START_ENTITY ATPase|appos|END_ENTITY	Cerebellar Purkinje neurones -LRB- PNs -RRB- express high levels of the plasma membrane calcium ATPase , PMCA2 , a transporter protein critical for the clearance of calcium from excitable cells .
19410650	0	calcium	33,40	PMCA2a	53,59	calcium	PMCA2a	MESH:D002118	491	Chemical	Gene	expression|nmod|START_ENTITY transporter|nsubj|expression transporter|dobj|END_ENTITY	Reduced expression of the `` fast '' calcium transporter PMCA2a during homeostatic plasticity .
16978418	0	calcium	16,23	PMCA4	32,37	calcium	PMCA4	MESH:D002118	493	Chemical	Gene	ATPase|compound|START_ENTITY ATPase|appos|END_ENTITY	Plasma membrane calcium ATPase -LRB- PMCA4 -RRB- : a housekeeper for RT-PCR relative quantification of polytopic membrane proteins .
25798335	0	calcium	85,92	PMCA4	0,5	calcium	PMCA4	MESH:D002118	491	Chemical	Gene	extrusion|compound|START_ENTITY delay|nmod|extrusion causes|dobj|delay causes|nsubj|mutation mutation|amod|END_ENTITY	PMCA4 -LRB- ATP2B4 -RRB- mutation in familial_spastic_paraplegia causes delay in intracellular calcium extrusion .
15670846	0	calcium	38,45	PMR1	23,27	calcium	PMR1	MESH:D002118	173176(Tax:6239)	Chemical	Gene	ATPase|compound|START_ENTITY END_ENTITY|appos|ATPase	Caenorhabditis_elegans PMR1 , a P-type calcium ATPase , is important for calcium/manganese homeostasis and oxidative stress response .
11583917	14	calcium	1919,1926	PRL	1970,1973	calcium	PRL	MESH:D002118	5617	Chemical	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Genistein reduces the influx of external calcium induced by DMS after short incubation with PRL and significantly inhibits both , calcium pools empty , and calcium influx is induced by DMS after overnight incubation with PRL .
16169864	12	calcium	1589,1596	PTG	1613,1616	calcium	PTH	MESH:D002118	24694(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|nmod|END_ENTITY	Decreased expression of calcium receptor in the PTG at baseline was partially recovered by the sevelamer treatment .
10453532	0	calcium	53,60	PTH	23,26	calcium	PTH	MESH:D002118	24694(Tax:10116)	Chemical	Gene	modulating|dobj|START_ENTITY Study|acl|modulating Study|nmod|mechanism mechanism|nmod|END_ENTITY	-LSB- Study of mechanism of PTH modulating cytosolic free calcium in rat DCT -RSB- .
11250917	0	calcium	84,91	PTH	62,65	calcium	PTH	MESH:D002118	24694(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY ionized|dobj|concentration ionized|nsubj|fragments fragments|nmod|decrease decrease|appos|END_ENTITY	Synthetic carboxyl-terminal fragments of parathyroid_hormone -LRB- PTH -RRB- decrease ionized calcium concentration in rats by acting on a receptor different from the PTH/PTH-related peptide receptor .
11606467	0	calcium	26,33	PTH	0,3	calcium	PTH	MESH:D002118	19226(Tax:10090)	Chemical	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	PTH regulates fetal blood calcium and skeletal mineralization independently of PTHrP .
11918740	12	calcium	1626,1633	PTH	1514,1517	calcium	PTH	MESH:D002118	24694(Tax:10116)	Chemical	Gene	affecting|nmod|START_ENTITY restores|advcl|affecting restores|dobj|levels levels|compound|END_ENTITY	CONCLUSIONS : In established chief-cell hyperplasia , P restriction restores normal serum PTH levels without affecting PTG hyperplasia , PTH synthesis , PTG cytosolic PTH or the PTH secretory response to calcium , suggesting an impaired exocytosis of PTH .
12046277	1	calcium	121,128	PTH	92,95	calcium	PTH	MESH:D002118	5741	Chemical	Gene	regulates|dobj|START_ENTITY regulates|nsubj|Parathyroid_hormone Parathyroid_hormone|appos|END_ENTITY	Parathyroid_hormone -LRB- PTH -RRB- regulates extracellular calcium .
12354614	0	calcium	94,101	PTH	71,74	calcium	PTH	MESH:D002118	24694(Tax:10116)	Chemical	Gene	stability|nmod|START_ENTITY acting|dep|stability acting|dep|END_ENTITY	Cis and trans acting factors in the regulation of parathyroid_hormone -LRB- PTH -RRB- mRNA stability by calcium and phosphate .
1248443	1	calcium	170,177	PTH	275,278	calcium	PTH	MESH:D002118	280903(Tax:9913)	Chemical	Gene	concentrations|nmod|START_ENTITY effects|nmod|concentrations compared|nsubjpass|effects compared|nmod|release release|nmod|parathyroid_hormone parathyroid_hormone|appos|END_ENTITY	The effects of varying extracellular concentrations of calcium and magnesium were compared on the release of 3H-labeled and immunoreactive parathyroid_hormone -LRB- PTH -RRB- by bovine parathyroid slices incubated for 4 h in vitro in media containing -LSB- 3H -RSB- leucine .
12944103	0	calcium	2,9	PTH	58,61	calcium	PTH	MESH:D002118	5741	Chemical	Gene	model|compound|START_ENTITY model|dep|orchestration orchestration|acl|acting acting|dobj|END_ENTITY	A calcium homeostasis model : orchestration of fast acting PTH and calcitonin with slow calcitriol .
14592784	0	calcium	110,117	PTH	0,3	calcium	PTH	MESH:D002118	5741	Chemical	Gene	impact|nmod|START_ENTITY impeding|nmod|impact promote|advcl|impeding promote|nsubj|excess excess|compound|END_ENTITY	PTH excess may promote weight_gain by impeding catecholamine-induced lipolysis-implications for the impact of calcium , vitamin_D , and alcohol on body weight .
15305177	0	calcium	21,28	PTH	43,46	calcium	PTH	MESH:D002118	5741	Chemical	Gene	load|compound|START_ENTITY load|nmod|END_ENTITY	Effect of acute oral calcium load on serum PTH and bone resorption in young healthy subjects : an overnight study .
15632475	0	calcium	72,79	PTH	151,154	calcium	PTH	MESH:D002118	5741	Chemical	Gene	receptor|compound|START_ENTITY control|nmod|receptor inhibiting|nmod|control Drugs|acl|inhibiting Drugs|dep|effect effect|nmod|point point|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Drugs inhibiting parathyroid_hormone -LRB- PTH -RRB- secretion by control of the calcium receptor -LRB- calcimimetics -RRB- -- effect on the set point of calcium-regulated PTH secretion -RSB- .
15632475	0	calcium	72,79	PTH	39,42	calcium	PTH	MESH:D002118	5741	Chemical	Gene	receptor|compound|START_ENTITY control|nmod|receptor inhibiting|nmod|control inhibiting|dobj|secretion secretion|appos|END_ENTITY	-LSB- Drugs inhibiting parathyroid_hormone -LRB- PTH -RRB- secretion by control of the calcium receptor -LRB- calcimimetics -RRB- -- effect on the set point of calcium-regulated PTH secretion -RSB- .
15775477	0	calcium	27,34	PTH	15,18	calcium	PTH	MESH:D002118	5741	Chemical	Gene	-RSB-|compound|START_ENTITY Regulation|nmod|-RSB- Regulation|nmod|gene gene|compound|END_ENTITY	-LSB- Regulation of PTH gene by calcium and phosphate -RSB- .
16219713	0	calcium	77,84	PTH	162,165	calcium	PTH	MESH:D002118	5741	Chemical	Gene	forms|nmod|START_ENTITY regulation|dep|forms regulation|dep|utility utility|acl|derived derived|nmod|generations generations|nmod|assays assays|compound|END_ENTITY	Acute regulation of circulating parathyroid_hormone -LRB- PTH -RRB- molecular forms by calcium : utility of PTH fragments/PTH -LRB- 1-84 -RRB- ratios derived from three generations of PTH assays .
16219713	0	calcium	77,84	PTH	53,56	calcium	PTH	MESH:D002118	5741	Chemical	Gene	forms|nmod|START_ENTITY regulation|dep|forms regulation|appos|END_ENTITY	Acute regulation of circulating parathyroid_hormone -LRB- PTH -RRB- molecular forms by calcium : utility of PTH fragments/PTH -LRB- 1-84 -RRB- ratios derived from three generations of PTH assays .
16219713	0	calcium	77,84	PTH	97,100	calcium	PTH	MESH:D002118	5741	Chemical	Gene	forms|nmod|START_ENTITY regulation|dep|forms regulation|dep|utility utility|nmod|ratios ratios|compound|END_ENTITY	Acute regulation of circulating parathyroid_hormone -LRB- PTH -RRB- molecular forms by calcium : utility of PTH fragments/PTH -LRB- 1-84 -RRB- ratios derived from three generations of PTH assays .
16279017	0	calcium	11,18	PTH	47,50	calcium	PTH	MESH:D002118	5741	Chemical	Gene	START_ENTITY|nmod|truncation truncation|nmod|END_ENTITY	-LSB- Effect of calcium on N-terminal truncation of PTH in human parathyroid cells -RSB- .
16840548	0	calcium	47,54	PTH	144,147	calcium	PTH	MESH:D002118	19226(Tax:10090)	Chemical	Gene	internalization|nmod|START_ENTITY Impact|nmod|internalization homeostasis|nsubj|Impact homeostasis|nmod|mice mice|acl|expressing expressing|dobj|parathyroid_hormone parathyroid_hormone|appos|END_ENTITY	Impact of impaired receptor internalization on calcium homeostasis in knock-in mice expressing a phosphorylation-deficient parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide_receptor .
1697736	0	calcium	40,47	PTH	11,14	calcium	PTH	MESH:D002118	100351309(Tax:9986)	Chemical	Gene	transport|compound|START_ENTITY Effects|nmod|transport Effects|nmod|END_ENTITY	Effects of PTH , calcitonin , and cAMP on calcium transport in rabbit distal nephron segments .
17204417	0	calcium	14,21	PTH	126,129	calcium	PTH	MESH:D002118	5741	Chemical	Gene	effecter|nsubj|START_ENTITY effecter|nmod|cells cells|acl:relcl|counter-balances counter-balances|dobj|effects effects|nmod|END_ENTITY	Extracellular calcium is a direct effecter of VDR levels in proximal tubule epithelial cells that counter-balances effects of PTH on renal Vitamin_D metabolism .
19063686	0	calcium	86,93	PTH	0,3	calcium	PTH	MESH:D002118	5741	Chemical	Gene	mutation|compound|START_ENTITY caused|nmod|mutation hypoparathyroidism|acl|caused child|nmod|hypoparathyroidism therapy|nmod|child END_ENTITY|dep|therapy	PTH -LRB- 1-34 -RRB- replacement therapy in a child with hypoparathyroidism caused by a sporadic calcium receptor mutation .
19250270	0	calcium	27,34	PTH	57,60	calcium	PTH	MESH:D002118	5741	Chemical	Gene	START_ENTITY|appos|parathyroid_hormone parathyroid_hormone|appos|END_ENTITY	Correlation between plasma calcium , parathyroid_hormone -LRB- PTH -RRB- and the metabolic_syndrome -LRB- MetS -RRB- in a community-based cohort of men and women .
19756348	0	calcium	67,74	PTH	26,29	calcium	PTH	MESH:D002118	5741	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of recombinant PTH -LRB- 1-34 -RRB- and PTH -LRB- 1-84 -RRB- on serum ionized calcium , 1,25-dihydroxyvitamin _ D , and urinary calcium excretion : a pilot study .
200741	0	calcium	73,80	PTH	92,95	calcium	PTH	MESH:D002118	100713626	Chemical	Gene	effects|compound|START_ENTITY effects|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Norepinephrine interference in adrenal hormone balance related to blood calcium effects of PTH -LRB- author 's transl -RRB- -RSB- .
20127382	0	calcium	72,79	PTH	27,30	calcium	PTH	MESH:D002118	5741	Chemical	Gene	concentration|compound|START_ENTITY regulated|nmod|concentration regulated|nsubjpass|cleavage cleavage|nmod|END_ENTITY	Amino terminal cleavage of PTH -LRB- 1-84 -RRB- to PTH -LRB- 7-84 -RRB- is regulated by serum calcium concentration via calcium-sensing receptor in hemodialysis patients .
20127382	0	calcium	72,79	PTH	40,43	calcium	PTH	MESH:D002118	5741	Chemical	Gene	concentration|compound|START_ENTITY regulated|nmod|concentration regulated|nsubjpass|cleavage cleavage|nmod|PTH PTH|nmod|END_ENTITY	Amino terminal cleavage of PTH -LRB- 1-84 -RRB- to PTH -LRB- 7-84 -RRB- is regulated by serum calcium concentration via calcium-sensing receptor in hemodialysis patients .
20308769	0	calcium	55,62	PTH	77,80	calcium	PTH	MESH:D002118	5741	Chemical	Gene	supplementation|nmod|START_ENTITY regimens|nmod|supplementation Impact|nmod|regimens END_ENTITY|nsubj|Impact	Impact of two regimens of vitamin_D supplementation on calcium - vitamin_D - PTH axis of schoolgirls of Delhi .
20601288	0	calcium	63,70	PTH	14,17	calcium	PTH	MESH:D002118	5741	Chemical	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Regulation of PTH secretion by 25-hydroxyvitamin_D and ionized calcium depends on vitamin_D status : a study in a large cohort of healthy subjects .
20823895	0	calcium	74,81	PTH	69,72	calcium	PTH	MESH:D002118	5741	Chemical	Gene	markers|compound|START_ENTITY END_ENTITY|dobj|markers	Effects of different doses of oral cholecalciferol on serum 25 -LRB- OH -RRB- D , PTH , calcium and bone markers during fall and winter in schoolchildren .
21515248	0	calcium	103,110	PTH	131,134	calcium	PTH	MESH:D002118	5741	Chemical	Gene	sensitivity|nmod|START_ENTITY Analysis|nmod|sensitivity Analysis|nmod|combination combination|nmod|END_ENTITY	Biochemical diagnosis of primary_hyperparathyroidism : Analysis of the sensitivity of total and ionized calcium in combination with PTH .
22179702	0	calcium	42,49	PTH	101,104	calcium	PTH	MESH:D002118	5741	Chemical	Gene	parameters|compound|START_ENTITY gastrectomy|nmod|parameters effects|nmod|gastrectomy effects|appos|END_ENTITY	Mid-term effects of sleeve gastrectomy on calcium metabolism parameters , vitamin_D and parathormone -LRB- PTH -RRB- in morbid obese women .
22790452	0	calcium	87,94	PTH	60,63	calcium	PTH	MESH:D002118	5741	Chemical	Gene	control|dobj|START_ENTITY Cinacalcet|acl|control Cinacalcet|nmod|patients patients|nmod|level level|compound|END_ENTITY	Cinacalcet for hemodialyzed patients with or without a high PTH level to control serum calcium and phosphorus : ECO -LRB- evaluation of cinacalcet HCl outcome -RRB- study .
23865697	0	calcium	90,97	PTH	50,53	calcium	PTH	MESH:D002118	5741	Chemical	Gene	homeostasis|compound|START_ENTITY pregnancy|nmod|homeostasis effect|nmod|pregnancy effect|nmod|infusion infusion|compound|END_ENTITY	The effect of continuous subcutaneous recombinant PTH -LRB- 1-34 -RRB- infusion during pregnancy on calcium homeostasis - a case report .
2427080	0	calcium	45,52	PTH	11,14	calcium	PTH	MESH:D002118	280903(Tax:9913)	Chemical	Gene	channels|compound|START_ENTITY mediated|nmod|channels mediated|nsubjpass|Control Control|nmod|secretion secretion|compound|END_ENTITY	Control of PTH secretion is mediated through calcium channels and is blocked by pertussis toxin treatment of parathyroid cells .
2450376	0	calcium	59,66	PTH	24,27	calcium	PTH	MESH:D002118	5741	Chemical	Gene	channels|compound|START_ENTITY mediated|nmod|channels mediated|nsubjpass|Control Control|nmod|secretion secretion|appos|END_ENTITY	Control of parathyroid -LRB- PTH -RRB- secretion is mediated through calcium channels .
25086672	0	calcium	11,18	PTH	115,118	calcium	PTH	MESH:D002118	5741	Chemical	Gene	homeostasis|compound|START_ENTITY Effects|nmod|homeostasis END_ENTITY|nsubj|Effects	Effects on calcium homeostasis of changing PTH replacement therapy of postoperative_hypoparathyroidism from intact PTH to teriparatide : a case series .
25086672	0	calcium	11,18	PTH	43,46	calcium	PTH	MESH:D002118	5741	Chemical	Gene	homeostasis|compound|START_ENTITY homeostasis|acl|changing changing|dobj|therapy therapy|compound|END_ENTITY	Effects on calcium homeostasis of changing PTH replacement therapy of postoperative_hypoparathyroidism from intact PTH to teriparatide : a case series .
25259820	0	calcium	6,13	PTH	34,37	calcium	PTH	MESH:D002118	5741	Chemical	Gene	START_ENTITY|dep|effect effect|nmod|END_ENTITY	Serum calcium and bone : effect of PTH , phosphate , vitamin_D and uremia .
2628520	2	calcium	298,305	PTH	415,418	calcium	INF	MESH:D002118	2694	Chemical	Gene	level|compound|START_ENTITY decreased|nsubj|level decreased|parataxis|level level|nsubj|parathyroid_hormone parathyroid_hormone|appos|END_ENTITY	Seven weeks after commencement of the therapy , the serum calcium -LRB- Ca -RRB- level decreased to 7.4 mg/dL , and the phosphorus -LRB- P -RRB- level increased to 7.2 mg/dL ; parathyroid_hormone -LRB- PTH -RRB- was at a critically low level .
26939669	0	calcium	50,57	PTH	28,31	calcium	PTH	MESH:D002118	5741	Chemical	Gene	level|compound|START_ENTITY END_ENTITY|nmod|level	Clinical Question : Elevated PTH with normal serum calcium level : a structured approach .
26996329	0	calcium	70,77	PTH	44,47	calcium	PTH	MESH:D002118	5741	Chemical	Gene	due|nmod|START_ENTITY END_ENTITY|amod|due	Mineral metabolism : The perils of a falling PTH due to high dialysate calcium .
2788385	0	calcium	60,67	PTH	10,13	calcium	PTH	MESH:D002118	5741	Chemical	Gene	homeostasis|compound|START_ENTITY indicator|nmod|homeostasis indicator|nsubj|END_ENTITY	Is intact PTH a sensitive biochemical indicator of deranged calcium homeostasis in vitamin_D deficiency ?
2841959	0	calcium	20,27	PTH	60,63	calcium	PTH	MESH:D002118	19226(Tax:10090)	Chemical	Gene	roles|nmod|START_ENTITY roles|nmod|action action|nmod|END_ENTITY	Different roles for calcium and cyclic_AMP in the action of PTH : studies in bone explants and isolated bone cells .
2850460	0	calcium	45,52	PTH	8,11	calcium	PTH	MESH:D002118	5741	Chemical	Gene	point|nmod|START_ENTITY rate|dobj|point rate|nsubj|END_ENTITY	Maximal PTH secretory rate and set point for calcium in normal subjects and patients with primary_hyperparathyroidism .
3025550	0	calcium	156,163	PTH	48,51	calcium	PTH	MESH:D002118	280903(Tax:9913)	Chemical	Gene	concentration|compound|START_ENTITY involve|nmod|concentration mechanism|acl:relcl|involve inhibit|nmod|mechanism inhibit|dobj|secretion secretion|compound|END_ENTITY	Ouabain and low extracellular potassium inhibit PTH secretion from bovine parathyroid cells by a mechanism that does not involve increases in the cytosolic calcium concentration .
3438499	0	calcium	45,52	PTH	122,125	calcium	PTH	MESH:D002118	5741	Chemical	Gene	relationship|nmod|START_ENTITY study|nmod|relationship -LSB-|dobj|study -LSB-|advcl|employing employing|dobj|kits kits|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- The study in the relationship between serum calcium and serum parathyroid_hormone -LRB- PTH -RRB- by employing the various kits of PTH assay -RSB- .
3515218	0	calcium	20,27	PTH	40,43	calcium	PTH	MESH:D002118	5741	Chemical	Gene	ionized|dobj|START_ENTITY ionized|nmod|END_ENTITY	High plasma ionized calcium with normal PTH and total calcium levels in normal-function kidney transplant recipients .
3791650	3	calcium	492,499	PTH	535,538	calcium	PTH	MESH:D002118	5741	Chemical	Gene	infusion|compound|START_ENTITY used|dobj|infusion used|advcl|inhibit inhibit|dobj|release release|nmod|END_ENTITY	Here we have used i.v. calcium infusion to inhibit the release of PTH and studied endogenous PTH bioactivity and immunoreactivity as well as the recovery of the bioactivity of added PTH in a normal subject and two patients with PSPI .
3933787	0	calcium	35,42	PTH	13,16	calcium	PTH	MESH:D002118	5741	Chemical	Gene	homeostasis|compound|START_ENTITY 2D|nmod|homeostasis 2D|nsubj|Influence Influence|nmod|END_ENTITY	Influence of PTH and 1,25 -LRB- OH -RRB- 2D on calcium homeostasis and bone mineral content after gastric surgery .
6097872	0	calcium	38,45	PTH	63,66	calcium	PTH	MESH:D002118	24694(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY concentration|nmod|END_ENTITY	Effect of chronic elevation of plasma calcium concentration by PTH or vitamin_D3 on blood pressure and hypotensive activity of nifedipine in rats .
6250408	0	calcium	17,24	PTH	10,13	calcium	PTH	MESH:D002118	280903(Tax:9913)	Chemical	Gene	transport|compound|START_ENTITY Effect|nmod|transport Effect|nmod|END_ENTITY	Effect of PTH on calcium transport across the cortical thick ascending limb of Henle 's loop .
6487306	0	calcium	98,105	PTH	0,3	calcium	PTH	MESH:D002118	280903(Tax:9913)	Chemical	Gene	decrease|nmod|START_ENTITY associated|nmod|decrease associated|nsubjpass|release release|compound|END_ENTITY	PTH release stimulated by high extracellular potassium is associated with a decrease in cytosolic calcium in bovine parathyroid cells .
6493158	0	calcium	95,102	PTH	57,60	calcium	PTH	MESH:D002118	5741	Chemical	Gene	reabsorption|nmod|START_ENTITY END_ENTITY|nmod|reabsorption	Normocalcemic primary_hyperparathyroidism : resistance to PTH effect on tubular reabsorption of calcium .
7424693	0	calcium	71,78	PTH	46,49	calcium	PTH	MESH:D002118	24694(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY mediated|dobj|release mediated|nsubj|Effect Effect|appos|END_ENTITY	Effect of uremic sera on parathyroid_hormone -LRB- PTH -RRB- mediated release of calcium from normal rat embryonal bone maintained in tissue culture .
7559893	0	calcium	95,102	PTH	136,139	calcium	PTH	MESH:D002118	5741	Chemical	Gene	START_ENTITY|amod|parathyroid_hormone parathyroid_hormone|dep|END_ENTITY	Hyperprolactinemia caused by lactation and pituitary_adenomas is associated with altered serum calcium , phosphate , parathyroid_hormone -LRB- PTH -RRB- , and PTH-related_peptide levels .
8109123	0	calcium	42,49	PTH	35,38	calcium	PTH	MESH:D002118	5741	Chemical	Gene	Suppressibility|nmod|START_ENTITY Suppressibility|nmod|END_ENTITY	Suppressibility of serum levels of PTH by calcium in the immediate postoperative period after surgery for primary_hyperparathyroidism .
8559479	0	calcium	15,22	PTH	41,44	calcium	PTH	MESH:D002118	5741	Chemical	Gene	loading|compound|START_ENTITY Effect|nmod|loading END_ENTITY|nsubj|Effect	Effect of oral calcium loading on intact PTH and calcitriol in idiopathic renal calcium stone formers and healthy controls .
8559479	0	calcium	80,87	PTH	41,44	calcium	PTH	MESH:D002118	5741	Chemical	Gene	formers|compound|START_ENTITY END_ENTITY|nmod|formers	Effect of oral calcium loading on intact PTH and calcitriol in idiopathic renal calcium stone formers and healthy controls .
8649940	0	calcium	32,39	PTH	72,75	calcium	PTH	MESH:D002118	5741	Chemical	Gene	decreasing|dobj|START_ENTITY decreasing|nmod|hemodialysis hemodialysis|nmod|levels levels|compound|END_ENTITY	-LSB- The effect of decreasing serum calcium in serum during hemodialysis on PTH levels in children with end stage renal_disease -RSB- .
8728272	0	calcium	27,34	PTH	56,59	calcium	PTH	MESH:D002118	5741	Chemical	Gene	concentration|compound|START_ENTITY concentration|nmod|level level|compound|END_ENTITY	The influence of dialysate calcium concentration on the PTH level in children undergoing CAPD .
8862484	0	calcium	27,34	PTH	6,9	calcium	PTH	MESH:D002118	5741	Chemical	Gene	load|compound|START_ENTITY END_ENTITY|nmod|load	Acute PTH response to oral calcium load and seasonal variation of vitamin_D status in healthy young adult subjects .
9076577	0	calcium	59,66	PTH	40,43	calcium	PTH	MESH:D002118	5741	Chemical	Gene	stimulation|nmod|START_ENTITY stimulation|nsubj|Evidence Evidence|nmod|point point|nmod|END_ENTITY	Evidence for both abnormal set point of PTH stimulation by calcium and adaptation to serum calcium in hemodialysis patients with hyperparathyroidism .
9076577	0	calcium	91,98	PTH	40,43	calcium	PTH	MESH:D002118	5741	Chemical	Gene	serum|dobj|START_ENTITY stimulation|xcomp|serum stimulation|nsubj|Evidence Evidence|nmod|point point|nmod|END_ENTITY	Evidence for both abnormal set point of PTH stimulation by calcium and adaptation to serum calcium in hemodialysis patients with hyperparathyroidism .
9383271	0	calcium	48,55	PTH	14,17	calcium	PTH	MESH:D002118	5741	Chemical	Gene	antagonist|nmod|START_ENTITY antagonist|nsubj|effect effect|nmod|END_ENTITY	The effect of PTH antagonist BIM-44002 on serum calcium and PTH levels in hypercalcemic hyperparathyroid patients .
9768650	7	calcium	1239,1246	PTH	1284,1287	calcium	PTH	MESH:D002118	5741	Chemical	Gene	mutations|compound|START_ENTITY patients|nmod|mutations normalized|nmod|patients normalized|nsubj|END_ENTITY	In patients with calcium receptor mutations -LRB- CaR -RRB- , once-daily PTH normalized urine calcium , provided that serum calcium was maintained at levels below normal range .
9768650	7	calcium	1305,1312	PTH	1284,1287	calcium	PTH	MESH:D002118	5741	Chemical	Gene	normalized|dobj|START_ENTITY normalized|nsubj|END_ENTITY	In patients with calcium receptor mutations -LRB- CaR -RRB- , once-daily PTH normalized urine calcium , provided that serum calcium was maintained at levels below normal range .
9768650	7	calcium	1334,1341	PTH	1284,1287	calcium	PTH	MESH:D002118	5741	Chemical	Gene	maintained|nsubjpass|START_ENTITY normalized|advcl|maintained normalized|nsubj|END_ENTITY	In patients with calcium receptor mutations -LRB- CaR -RRB- , once-daily PTH normalized urine calcium , provided that serum calcium was maintained at levels below normal range .
9799069	0	calcium	18,25	PTH	149,152	calcium	PTH	MESH:D002118	5741	Chemical	Gene	dependency|nmod|START_ENTITY set|nsubj|dependency set|parataxis|regarding regarding|nmod|secretion secretion|compound|END_ENTITY	The dependency of calcium set point on basal plasma calcium in dialysis patients : a better explanation for the discrepancies regarding its link with PTH secretion than methodological differences .
9799069	0	calcium	52,59	PTH	149,152	calcium	PTH	MESH:D002118	5741	Chemical	Gene	set|nmod|START_ENTITY set|parataxis|regarding regarding|nmod|secretion secretion|compound|END_ENTITY	The dependency of calcium set point on basal plasma calcium in dialysis patients : a better explanation for the discrepancies regarding its link with PTH secretion than methodological differences .
998799	0	calcium	21,28	PTH	59,62	calcium	PTH	MESH:D002118	24694(Tax:10116)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|dep|roles roles|nmod|END_ENTITY	Regulation of plasma calcium in rats : age-related roles of PTH and calcitonin .
27000502	0	calcium	134,141	PTH2R	40,45	calcium	PTH2R	MESH:D002118	5746	Chemical	Gene	regulate|dobj|START_ENTITY regulate|nsubj|END_ENTITY	The parathyroid_hormone second receptor PTH2R , and its ligand tuberoinfundibular peptide of 39 residues TIP39 , regulate intracellular calcium and influence keratinocyte differentiation .
20484696	0	calcium	28,35	PTHrP	8,13	calcium	PTHrP	MESH:D002118	5744	Chemical	Gene	transport|compound|START_ENTITY regulation|nmod|transport regulation|compound|END_ENTITY	Piscine PTHrP regulation of calcium and phosphate transport in winter flounder renal proximal tubule primary cultures .
14575870	0	calcium	52,59	PTP1B	21,26	calcium	PTP1B	MESH:D002118	5770	Chemical	Gene	influx|compound|START_ENTITY modulates|dobj|influx modulates|nsubj|END_ENTITY	Tyrosine phosphatase PTP1B modulates store-operated calcium influx .
7608776	0	calcium	32,39	Pancreatic_polypeptide	0,22	calcium	Pancreatic polypeptide	MESH:D002118	24677(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY inhibits|dobj|channels inhibits|nsubj|END_ENTITY	Pancreatic_polypeptide inhibits calcium channels in rat sympathetic neurons via two signaling pathways .
10783492	0	calcium	129,136	Parathyroid_hormone	0,19	calcium	Parathyroid hormone	MESH:D002118	5741	Chemical	Gene	light|appos|START_ENTITY associated|nmod|light explanation|dep|associated promoter|dep|explanation promoter|nsubj|END_ENTITY	Parathyroid_hormone may be a cancer promoter - an explanation for the decrease in cancer risk associated with ultraviolet light , calcium , and vitamin_D .
12639904	0	calcium	110,117	Parathyroid_hormone	0,19	calcium	Parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY involving|dobj|channels formation|acl|involving enhances|dobj|formation enhances|nsubj|END_ENTITY	Parathyroid_hormone enhances mechanically induced bone formation , possibly involving L-type voltage-sensitive calcium channels .
1309659	0	calcium	45,52	Parathyroid_hormone	0,19	calcium	Parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	pump|nsubj|START_ENTITY stimulates|ccomp|pump stimulates|nsubj|END_ENTITY	Parathyroid_hormone stimulates ATP-dependent calcium pump activity by a different mode in proximal and distal tubules of the rat .
1320249	0	calcium	29,36	Parathyroid_hormone	0,19	calcium	Parathyroid hormone	MESH:D002118	5741	Chemical	Gene	enhances|dobj|START_ENTITY enhances|nsubj|END_ENTITY	Parathyroid_hormone enhances calcium current in snail neurones -- simulation of the effect by phorbol_esters .
15300474	0	calcium	40,47	Parathyroid_hormone	0,19	calcium	Parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	increases|dobj|START_ENTITY increases|nsubj|END_ENTITY	Parathyroid_hormone increases cytosolic calcium in neonatal nephron through protein_kinase_C pathway .
15758504	0	calcium	31,38	Parathyroid_hormone	0,19	calcium	Parathyroid hormone	MESH:D002118	5741	Chemical	Gene	control|compound|START_ENTITY control|compound|END_ENTITY	Parathyroid_hormone and plasma calcium control : an editorial .
1661094	0	calcium	56,63	Parathyroid_hormone	0,19	calcium	Parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY modulator|nmod|channels END_ENTITY|dep|modulator	Parathyroid_hormone : an endogenous modulator of cardiac calcium channels .
1726176	0	calcium	48,55	Parathyroid_hormone	0,19	calcium	Parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY inhibits|dobj|channels inhibits|nsubj|END_ENTITY	Parathyroid_hormone selectively inhibits L-type calcium channels in single vascular smooth muscle cells of the rat .
187537	0	calcium	88,95	Parathyroid_hormone	0,19	calcium	Parathyroid hormone	MESH:D002118	280903(Tax:9913)	Chemical	Gene	mechanism|compound|START_ENTITY effect|nmod|mechanism END_ENTITY|dep|effect	Parathyroid_hormone and calcitonin : no direct effect on vitamin_D3-mediated , intestinal calcium absorptive mechanism .
18832101	0	calcium	51,58	Parathyroid_hormone	0,19	calcium	Parathyroid hormone	MESH:D002118	19226(Tax:10090)	Chemical	Gene	content|compound|START_ENTITY regulating|dobj|content contributes|advcl|regulating contributes|nsubj|END_ENTITY	Parathyroid_hormone contributes to regulating milk calcium content and modulates neonatal bone formation cooperatively with calcium .
2154216	0	calcium	69,76	Parathyroid_hormone	0,19	calcium	Parathyroid hormone	MESH:D002118	5741	Chemical	Gene	rise|nmod|START_ENTITY causes|dobj|rise causes|nsubj|END_ENTITY	Parathyroid_hormone causes a transient rise in intracellular ionized calcium in vascular smooth muscle cells .
2169032	0	calcium	47,54	Parathyroid_hormone	1,20	calcium	Parathyroid hormone	MESH:D002118	5741	Chemical	Gene	conduction|compound|START_ENTITY stimulation|nmod|conduction stimulation|compound|END_ENTITY	-LSB- Parathyroid_hormone stimulation of nerve cell calcium conduction -RSB- .
3021151	0	calcium	66,73	Parathyroid_hormone	0,19	calcium	Parathyroid hormone	MESH:D002118	280903(Tax:9913)	Chemical	Gene	changes|nmod|START_ENTITY respond|nmod|changes respond|nsubj|secretion secretion|amod|END_ENTITY	Parathyroid_hormone secretion does not respond to changes of free calcium in electropermeabilized bovine parathyroid cells , but is stimulated with phorbol_ester and cyclic_AMP .
3037917	0	calcium	51,58	Parathyroid_hormone	0,19	calcium	Parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	elevates|dobj|START_ENTITY elevates|nsubj|END_ENTITY	Parathyroid_hormone acutely elevates intracellular calcium in osteoblastlike cells .
3381885	0	calcium	40,47	Parathyroid_hormone	0,19	calcium	Parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY changes|nmod|transport mediates|dobj|changes mediates|nsubj|END_ENTITY	Parathyroid_hormone mediates changes in calcium transport in uremic rat brain synaptosomes .
3394830	0	calcium	53,60	Parathyroid_hormone	0,19	calcium	Parathyroid hormone	MESH:D002118	403986(Tax:9615)	Chemical	Gene	effects|nmod|START_ENTITY effects|amod|END_ENTITY	Parathyroid_hormone effects on skeletal exchangeable calcium and bone blood flow .
3747837	0	calcium	33,40	Parathyroid_hormone	0,19	calcium	Parathyroid hormone	MESH:D002118	5741	Chemical	Gene	homeostasis|compound|START_ENTITY homeostasis|amod|END_ENTITY	Parathyroid_hormone and neonatal calcium homeostasis : evidence for secondary_hyperparathyroidism in the Asian neonate .
3755396	0	calcium	31,38	Parathyroid_hormone	0,19	calcium	Parathyroid hormone	MESH:D002118	5741	Chemical	Gene	transport|compound|START_ENTITY transport|amod|END_ENTITY	Parathyroid_hormone stimulates calcium transport in perfused duodena from normal chicks : comparison with the rapid -LRB- transcaltachic -RRB- effect of 1,25-dihydroxyvitamin _ D3 .
6489264	0	calcium	33,40	Parathyroid_hormone	0,19	calcium	Parathyroid hormone	MESH:D002118	396436(Tax:9031)	Chemical	Gene	responses|nmod|START_ENTITY responses|amod|END_ENTITY	Parathyroid_hormone responses to calcium stress during eggshell calcification .
6687356	0	calcium	59,66	Parathyroid_hormone	0,19	calcium	Parathyroid hormone	MESH:D002118	280903(Tax:9913)	Chemical	Gene	effects|nmod|START_ENTITY ribonucleic_acid|dep|effects ribonucleic_acid|amod|END_ENTITY	Parathyroid_hormone messenger ribonucleic_acid : effects of calcium on cellular regulation in vitro .
6775790	0	calcium	25,32	Parathyroid_hormone	0,19	calcium	Parathyroid hormone	MESH:D002118	5741	Chemical	Gene	ionophore|compound|START_ENTITY END_ENTITY|nmod|ionophore	Parathyroid_hormone as a calcium ionophore in bone cells : tests of specificity .
7318903	0	calcium	31,38	Parathyroid_hormone	0,19	calcium	Parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY effects|nmod|metabolism effects|amod|END_ENTITY	Parathyroid_hormone effects on calcium metabolism in the rat are impaired by 5-ethyl-5 ' - -LRB- 1-methylpropyl -RRB- -2 - thiobarbiturate -LRB- inaktin -RRB- .
7506210	0	calcium	53,60	Parathyroid_hormone	0,19	calcium	Parathyroid hormone	MESH:D002118	100351309(Tax:9986)	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|dobj|transport	Parathyroid_hormone and hydrochlorothiazide increase calcium transport by the luminal membrane of rabbit distal nephron segments through different pathways .
7743158	0	calcium	30,37	Parathyroid_hormone	0,19	calcium	Parathyroid hormone	MESH:D002118	19226(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY action|nmod|transport action|amod|END_ENTITY	Parathyroid_hormone action in calcium transport in the distal nephron .
7792032	0	calcium	43,50	Parathyroid_hormone	0,19	calcium	Parathyroid hormone	MESH:D002118	5741	Chemical	Gene	concentration|compound|START_ENTITY END_ENTITY|dobj|concentration	Parathyroid_hormone and platelet cytosolic calcium concentration in essential hypertension .
8125568	0	calcium	38,45	Parathyroid_hormone	0,19	calcium	Parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	mobilization|compound|START_ENTITY inhibit|dobj|mobilization inhibit|nsubj|analogues analogues|amod|END_ENTITY	Parathyroid_hormone analogues inhibit calcium mobilization in cultured vascular cells .
8322930	0	calcium	40,47	Parathyroid_hormone	0,19	calcium	Parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY increases|dobj|concentration increases|nsubj|END_ENTITY	Parathyroid_hormone increases cytosolic calcium concentration in adult rat cardiac myocytes .
8384279	0	calcium	37,44	Parathyroid_hormone	0,19	calcium	Parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	raises|dobj|START_ENTITY raises|nsubj|END_ENTITY	Parathyroid_hormone raises cytosolic calcium in pancreatic islets : study on mechanisms .
8396211	0	calcium	40,47	Parathyroid_hormone	0,19	calcium	Parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	increases|dobj|START_ENTITY increases|nsubj|END_ENTITY	Parathyroid_hormone increases cytosolic calcium of thymocytes .
8536604	0	calcium	35,42	Parathyroid_hormone	0,19	calcium	Parathyroid hormone	MESH:D002118	19226(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY stimulation|nmod|transport stimulation|amod|END_ENTITY	Parathyroid_hormone stimulation of calcium transport is mediated by dual signaling mechanisms involving protein kinase A and protein_kinase_C .
9357780	0	calcium	31,38	Parathyroid_hormone	0,19	calcium	Parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	influx|compound|START_ENTITY stimulates|dobj|influx stimulates|nsubj|END_ENTITY	Parathyroid_hormone stimulates calcium influx and the cAMP messenger system in rat enterocytes .
9824432	0	calcium	32,39	Parathyroid_hormone	0,19	calcium	Parathyroid hormone	MESH:D002118	5741	Chemical	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	Parathyroid_hormone and ionized calcium levels are related to the severity of illness and survival in critically_ill patients .
12429049	0	calcium	75,82	Parathyroid_hormone-related_peptide	0,35	calcium	Parathyroid hormone-related peptide	MESH:D002118	5744	Chemical	Gene	transport|compound|START_ENTITY stimulates|dobj|transport stimulates|nsubj|amide amide|amod|END_ENTITY	Parathyroid_hormone-related_peptide -LRB- 38-94 -RRB- _ amide stimulates ATP-dependent calcium transport in the Basal plasma membrane of the human syncytiotrophoblast .
1564419	0	calcium	52,59	Parathyroid_hormone-related_peptide	0,35	calcium	Parathyroid hormone-related peptide	MESH:D002118	100860907	Chemical	Gene	secretion|compound|START_ENTITY stimulate|dobj|secretion stimulate|nsubj|END_ENTITY	Parathyroid_hormone-related_peptide might stimulate calcium secretion into the milk of goats .
8986793	0	calcium	70,77	Parathyroid_hormone-related_peptide	0,35	calcium	Parathyroid hormone-related peptide	MESH:D002118	19227(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY regulates|dobj|transport regulates|nsubj|END_ENTITY	Parathyroid_hormone-related_peptide -LRB- PTHrP -RRB- regulates fetal-placental calcium transport through a receptor distinct from the PTH/PTHrP _ receptor .
16763076	0	calcium	57,64	Parathyroid_hormone-related_protein	0,35	calcium	Parathyroid hormone-related protein	MESH:D002118	5744	Chemical	Gene	transport|compound|START_ENTITY regulates|dobj|transport regulates|nsubj|END_ENTITY	Parathyroid_hormone-related_protein regulates intestinal calcium transport in sea bream -LRB- Sparus auratus -RRB- .
15092534	1	calcium	80,87	Part_1	48,54	calcium	Part 1	MESH:D002118	25859	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|dep|effect	Part_1 : The effect of exogenous calcium on lead accumulation by earthworms under field and laboratory conditions .
24575627	0	calcium	21,28	Part_1	97,103	calcium	Part 1	MESH:D002118	25859	Chemical	Gene	alkoxides|compound|START_ENTITY challenging|dobj|alkoxides challenging|nmod|spectrometry spectrometry|appos|END_ENTITY	Study of challenging calcium alkoxides in solution by electrospray ionization mass spectrometry -LRB- Part_1 -RRB- .
9726983	0	calcium	66,73	Phosphoinositide_3-kinase	0,25	calcium	Phosphoinositide 3-kinase	MESH:D002118	5293	Chemical	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Phosphoinositide_3-kinase regulates phospholipase Cgamma-mediated calcium signaling .
10515420	0	calcium	56,63	Phospholipase_A2	0,16	calcium	Phospholipase A2	MESH:D002118	104974671	Chemical	Gene	mobilization|compound|START_ENTITY augments|dobj|mobilization augments|nsubj|END_ENTITY	Phospholipase_A2 augments contraction and intracellular calcium mobilization through thromboxane_A2 in bovine tracheal smooth muscle .
2901860	0	calcium	81,88	Phospholipase_C	0,15	calcium	Phospholipase C	MESH:D002118	100009319(Tax:9986)	Chemical	Gene	distribution|nmod|START_ENTITY END_ENTITY|dep|distribution	Phospholipase_C in rabbit thymocytes : subcellular distribution and influences of calcium and GTP gamma S on the substrate dependence of cytosolic and plasma membrane-associated phospholipase_C .
11906165	0	calcium	26,33	Phospholipase_D	0,15	calcium	Phospholipase D	MESH:D002118	2822	Chemical	Gene	frequency|compound|START_ENTITY regulates|dobj|frequency regulates|nsubj|END_ENTITY	Phospholipase_D regulates calcium oscillation frequency and nuclear factor-kappaB activity in histamine - stimulated human endothelial cells .
2505772	0	calcium	72,79	Phospholipase_D	0,15	calcium	Phospholipase D	MESH:D002118	2822	Chemical	Gene	implications|nmod|START_ENTITY END_ENTITY|dep|implications	Phospholipase_D in homogenates from HL-60 granulocytes : implications of calcium and G protein control .
1324148	0	calcium	62,69	Pituitary_adenylate_cyclase-activating_polypeptide	0,50	calcium	Pituitary adenylate cyclase-activating polypeptide	MESH:D002118	116	Chemical	Gene	mobilization|compound|START_ENTITY stimulates|dobj|mobilization stimulates|nsubj|END_ENTITY	Pituitary_adenylate_cyclase-activating_polypeptide stimulates calcium mobilization in amphibian pituitary cells .
8483802	0	calcium	84,91	Pituitary_adenylate_cyclase_activating_polypeptide	0,50	calcium	Pituitary adenylate cyclase activating polypeptide	MESH:D002118	24166(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY increases|dobj|concentration increases|nsubj|END_ENTITY	Pituitary_adenylate_cyclase_activating_polypeptide -LRB- PACAP -RRB- increases cytosolic-free calcium concentration in folliculo-stellate cells and somatotropes of rat pituitary .
18768333	0	calcium	69,76	Plasminogen_activator_inhibitor-1	0,33	calcium	Plasminogen activator inhibitor-1	MESH:D002118	5054	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	Plasminogen_activator_inhibitor-1 is associated with coronary artery calcium in Type 1 diabetes .
1848574	0	calcium	64,71	Platelet-activating_factor	0,26	calcium	Platelet-activating factor	MESH:D002118	9768	Chemical	Gene	increase|nmod|START_ENTITY induces|dobj|increase induces|nsubj|END_ENTITY	Platelet-activating_factor induces an increase in intracellular calcium and expression of regulatory genes in human B lymphoblastoid cells .
3949010	0	calcium	51,58	Platelet-activating_factor	0,26	calcium	Platelet-activating factor	MESH:D002118	9768	Chemical	Gene	mobilizes|dobj|START_ENTITY mobilizes|nsubj|END_ENTITY	Platelet-activating_factor mobilizes intracellular calcium in vascular smooth muscle cells .
11405247	0	calcium	51,58	Prolactin	0,9	calcium	Prolactin	MESH:D002118	24683(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY stimulates|dobj|transport stimulates|nsubj|END_ENTITY	Prolactin directly stimulates transcellular active calcium transport in the duodenum of female rats .
11583917	0	calcium	18,25	Prolactin	0,9	calcium	Prolactin	MESH:D002118	5617	Chemical	Gene	influx|compound|START_ENTITY induces|dobj|influx induces|nsubj|END_ENTITY	Prolactin induces calcium influx and release from intracellular pools in human T lymphocytes by activation of tyrosine kinases .
15471574	0	calcium	55,62	Prolactin	0,9	calcium	Prolactin	MESH:D002118	24683(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY stimulated|dobj|transport stimulated|nsubj|END_ENTITY	Prolactin directly stimulated the solvent drag-induced calcium transport in the duodenum of female rats .
17823618	0	calcium	50,57	Prolactin	0,9	calcium	Prolactin	MESH:D002118	24683(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY regulator|nmod|transport regulator|nsubj|END_ENTITY	Prolactin is an important regulator of intestinal calcium transport .
1815141	0	calcium	100,107	Prolactin	0,9	calcium	Prolactin	MESH:D002118	24683(Tax:10116)	Chemical	Gene	absence|nmod|START_ENTITY striatum|nmod|absence stimulates|nmod|striatum stimulates|nsubj|END_ENTITY	Prolactin stimulates dopamine release from the rat corpus striatum in the absence of extra-cellular calcium .
1954871	0	calcium	35,42	Prolactin	0,9	calcium	Prolactin	MESH:D002118	24683(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY increases|dobj|concentration increases|nsubj|END_ENTITY	Prolactin increases cytosolic free calcium concentration in hepatocytes of lactating rats .
23206706	0	calcium	32,39	Prolactin	0,9	calcium	Prolactin	MESH:D002118	24683(Tax:10116)	Chemical	Gene	channel-mediated|nsubj|START_ENTITY stimulates|ccomp|channel-mediated stimulates|nsubj|END_ENTITY	Prolactin stimulates the L-type calcium channel-mediated transepithelial calcium transport in the duodenum of male rats .
23206706	0	calcium	73,80	Prolactin	0,9	calcium	Prolactin	MESH:D002118	24683(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY channel-mediated|dobj|transport stimulates|ccomp|channel-mediated stimulates|nsubj|END_ENTITY	Prolactin stimulates the L-type calcium channel-mediated transepithelial calcium transport in the duodenum of male rats .
2319907	0	calcium	58,65	Prostaglandin_D2	0,16	calcium	Prostaglandin D2	MESH:D002118	5730	Chemical	Gene	flux|compound|START_ENTITY modulates|dobj|flux modulates|nsubj|END_ENTITY	Prostaglandin_D2 modulates human neutrophil intracellular calcium flux and inhibits superoxide release via its ring carbonyl .
17184798	0	calcium	65,72	Protein_kinase	0,14	calcium	Protein kinase	MESH:D002118	101219563	Chemical	Gene	effect|nmod|START_ENTITY activity|dep|effect activity|amod|END_ENTITY	Protein_kinase activity in Cucumis_sativus cotyledons : effect of calcium and light .
11080259	0	calcium	44,51	Protein_kinase_C	0,16	calcium	Protein kinase C	MESH:D002118	112476	Chemical	Gene	entry|compound|START_ENTITY activates|dobj|entry activates|nsubj|END_ENTITY	Protein_kinase_C activates non-capacitative calcium entry in human platelets .
1282220	0	calcium	134,141	Protein_kinase_C	0,16	calcium	Protein kinase C	MESH:D002118	24681(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY 5-hydroxytryptamine|dep|role channels|amod|5-hydroxytryptamine release|nmod|channels modulates|dobj|release modulates|nsubj|END_ENTITY	Protein_kinase_C modulates the release of -LSB- 3H -RSB- 5-hydroxytryptamine in the spinal cord of the rat : the role of L-type voltage-dependent calcium channels .
15572354	0	calcium	117,124	Protein_kinase_C	0,16	calcium	Protein kinase C	MESH:D002118	112476	Chemical	Gene	overexpressing|dobj|START_ENTITY cells|acl|overexpressing stores|nmod|cells modulates|nmod|stores modulates|nsubj|END_ENTITY	Protein_kinase_C modulates agonist-sensitive release of Ca2 + from internal stores in HEK293 cells overexpressing the calcium sensing receptor .
15765781	0	calcium	93,100	Protein_kinase_C	0,16	calcium	Protein kinase C	MESH:D002118	112476	Chemical	Gene	A23187|compound|START_ENTITY cells|nmod|A23187 inhibits|nmod|cells inhibits|nsubj|blockade blockade|amod|END_ENTITY	Protein_kinase_C blockade inhibits differentiation of myeloid blasts into dendritic cells by calcium ionophore A23187 .
2271522	0	calcium	34,41	Protein_kinase_C	0,16	calcium	Protein kinase C	MESH:D002118	112476	Chemical	Gene	interaction|nmod|START_ENTITY interaction|amod|END_ENTITY	Protein_kinase_C interaction with calcium : a phospholipid-dependent process .
7532210	0	calcium	27,34	Protein_kinase_C	0,16	calcium	Protein kinase C	MESH:D002118	24681(Tax:10116)	Chemical	Gene	sensitivity|compound|START_ENTITY modulates|dobj|sensitivity modulates|nsubj|END_ENTITY	Protein_kinase_C modulates calcium sensitivity of nitric_oxide synthase in cerebellar slices .
7536806	0	calcium	27,34	Protein_kinase_C	0,16	calcium	Protein kinase C	MESH:D002118	24681(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY modulates|dobj|channels modulates|nsubj|END_ENTITY	Protein_kinase_C modulates calcium channels in isolated presynaptic nerve terminals of rat hippocampus .
8746951	0	calcium	42,49	Protein_kinase_C	0,16	calcium	Protein kinase C	MESH:D002118	112476	Chemical	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	Protein_kinase_C modulates cytosolic free calcium by stimulating calcium pump activity in Jurkat T cells .
8746951	0	calcium	65,72	Protein_kinase_C	0,16	calcium	Protein kinase C	MESH:D002118	112476	Chemical	Gene	activity|compound|START_ENTITY stimulating|dobj|activity modulates|advcl|stimulating modulates|nsubj|END_ENTITY	Protein_kinase_C modulates cytosolic free calcium by stimulating calcium pump activity in Jurkat T cells .
9814702	0	calcium	53,60	Protein_kinase_C	0,16	calcium	Protein kinase C	MESH:D002118	112476	Chemical	Gene	machine|nmod|START_ENTITY END_ENTITY|nmod|machine	Protein_kinase_C as a molecular machine for decoding calcium and diacylglycerol signals .
9819259	0	calcium	48,55	Protein_kinase_C	0,16	calcium	Protein kinase C	MESH:D002118	112476	Chemical	Gene	channels|compound|START_ENTITY class|nmod|channels regulates|dobj|class regulates|nsubj|END_ENTITY	Protein_kinase_C regulates a vesicular class of calcium channels in the bag cell neurons of aplysia .
19011160	0	calcium	41,48	Protein_kinase_C-epsilon	0,24	calcium	Protein kinase C-epsilon	MESH:D002118	5581	Chemical	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Protein_kinase_C-epsilon regulates local calcium signaling in airway smooth muscle cells .
23175814	0	calcium	13,20	RIM	0,3	calcium	RIM	MESH:D002118	42150(Tax:7227)	Chemical	Gene	accumulation|compound|START_ENTITY promotes|dobj|accumulation promotes|nsubj|END_ENTITY	RIM promotes calcium channel accumulation at active zones of the Drosophila neuromuscular junction .
11053125	0	calcium	54,61	RYR1	0,4	calcium	RYR1	MESH:D002118	20190(Tax:10090)	Chemical	Gene	units|compound|START_ENTITY assembly|nmod|units roles|nmod|assembly have|dobj|roles have|nsubj|END_ENTITY	RYR1 and RYR3 have different roles in the assembly of calcium release units of skeletal muscle .
11500484	0	calcium	28,35	RYR1	12,16	calcium	RYR1	MESH:D002118	6261	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Coupling of RYR1 and L-type calcium channels via calmodulin binding domains .
11575546	0	calcium	114,121	RYR1	139,143	calcium	RYR1	MESH:D002118	606491(Tax:9615)	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Autosomal dominant canine malignant hyperthermia is caused by a mutation in the gene encoding the skeletal muscle calcium release channel -LRB- RYR1 -RRB- .
11591164	0	calcium	21,28	RYR1	122,126	calcium	RYR1	MESH:D002118	6261	Chemical	Gene	sites|compound|START_ENTITY control|nsubj|sites control|nmod|inhibitor inhibitor|nmod|END_ENTITY	The carboxy-terminal calcium binding sites of calmodulin control calmodulin 's switch from an activator to an inhibitor of RYR1 .
18084979	0	calcium	39,46	RYR1	102,106	calcium	RYR1	MESH:D002118	6261	Chemical	Gene	concentrations|compound|START_ENTITY changes|nmod|concentrations changes|nmod|muscles muscles|nmod|carriers carriers|compound|END_ENTITY	Propofol-induced changes in myoplasmic calcium concentrations in cultured human skeletal muscles from RYR1 mutation carriers .
9582122	0	calcium	56,63	RasGRP	0,6	calcium	RasGRP	MESH:D002118	10125	Chemical	Gene	protein|nmod|START_ENTITY END_ENTITY|dep|protein	RasGRP , a Ras guanyl_nucleotide - releasing protein with calcium - and diacylglycerol-binding motifs .
21844488	0	calcium	84,91	Receptor_for_activated_protein_kinase_C1	0,40	calcium	Receptor for activated protein kinase C1	MESH:D002118	83427(Tax:10116)	Chemical	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Receptor_for_activated_protein_kinase_C1 regulates cell proliferation by modulating calcium signaling .
12356577	0	calcium	64,71	Regulator_of_G-protein_signaling_protein_2	0,42	calcium	Regulator of G-protein signaling protein 2	MESH:D002118	5997	Chemical	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	Regulator_of_G-protein_signaling_protein_2 modulates purinergic calcium and ciliary beat frequency responses in airway epithelia .
16685219	0	calcium	28,35	Renin	0,5	calcium	Renin	MESH:D002118	5972	Chemical	Gene	current|compound|START_ENTITY increments|dobj|current increments|nsubj|END_ENTITY	Renin increments the inward calcium current in the failing heart .
2866707	0	calcium	7,14	Renin	0,5	calcium	Renin	MESH:D002118	5972	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|appos|metabolism	Renin , calcium metabolism and the pathophysiologic basis of antihypertensive therapy .
19162191	0	calcium	39,46	RhoA	58,62	calcium	RhoA	MESH:D002118	395442(Tax:9031)	Chemical	Gene	influx|compound|START_ENTITY influx|nmod|END_ENTITY	N-cadherin modulates voltage activated calcium influx via RhoA , p120-catenin , and myosin-actin interaction .
12207911	0	calcium	26,33	RyR1	50,54	calcium	RyR1	MESH:D002118	114207(Tax:10116)	Chemical	Gene	release|nsubj|START_ENTITY release|dobj|END_ENTITY	ADP-ribose stimulates the calcium release channel RyR1 in skeletal muscle of rat .
15469935	0	calcium	32,39	RyR1	103,107	calcium	RyR1	MESH:D002118	100009540(Tax:9986)	Chemical	Gene	START_ENTITY|nmod|ryanodine_receptor_isoform ryanodine_receptor_isoform|appos|END_ENTITY	Mutational analysis of putative calcium binding motifs within the skeletal ryanodine_receptor_isoform , RyR1 .
16120606	0	calcium	87,94	RyR1	27,31	calcium	RyR1	MESH:D002118	6261	Chemical	Gene	entry|compound|START_ENTITY independent|nsubj|entry reveal|ccomp|independent reveal|dep|END_ENTITY	Ryanodine_receptor_type_1 -LRB- RyR1 -RRB- mutations C4958S and C4961S reveal excitation-coupled calcium entry -LRB- ECCE -RRB- is independent of sarcoplasmic reticulum store depletion .
17713923	8	calcium	2152,2159	RyR1	2174,2178	calcium	RyR1	MESH:D002118	6261	Chemical	Gene	dependence|compound|START_ENTITY dependence|nmod|inhibition inhibition|amod|END_ENTITY	Occupancy of calcium-binding sites in the N-domain of CaM mirrors the calcium dependence of RyR1 inhibition observed at activating calcium levels , where -LSB- Ca -RSB- 1/2 = 4.3 + / - 0.4 microM , suggesting a direct regulation of RyR1 function upon the calcium-dependent activation of CaM .
17713923	8	calcium	2213,2220	RyR1	2174,2178	calcium	RyR1	MESH:D002118	6261	Chemical	Gene	levels|compound|START_ENTITY activating|dobj|levels observed|advcl|activating inhibition|acl|observed inhibition|amod|END_ENTITY	Occupancy of calcium-binding sites in the N-domain of CaM mirrors the calcium dependence of RyR1 inhibition observed at activating calcium levels , where -LSB- Ca -RSB- 1/2 = 4.3 + / - 0.4 microM , suggesting a direct regulation of RyR1 function upon the calcium-dependent activation of CaM .
17942409	0	calcium	28,35	RyR1	87,91	calcium	RyR1	MESH:D002118	6261	Chemical	Gene	entry|compound|START_ENTITY associated|nsubjpass|entry associated|nmod|expression expression|nmod|mutations mutations|amod|END_ENTITY	Enhanced excitation-coupled calcium entry in myotubes is associated with expression of RyR1 malignant_hyperthermia mutations .
21454501	0	calcium	77,84	RyR1	46,50	calcium	RyR1	MESH:D002118	6261	Chemical	Gene	protein|compound|START_ENTITY interaction|nmod|protein interaction|appos|END_ENTITY	Identification of novel ryanodine receptor 1 -LRB- RyR1 -RRB- protein interaction with calcium homeostasis endoplasmic reticulum protein -LRB- CHERP -RRB- .
24303040	0	calcium	34,41	RyR1	126,130	calcium	RyR1	MESH:D002118	6261	Chemical	Gene	transients|compound|START_ENTITY depletion|nmod|transients Effect|nmod|depletion Effect|nmod|stabilizers stabilizers|amod|END_ENTITY	Effect of Calstabin1 depletion on calcium transients and energy utilization in muscle fibers and treatment opportunities with RyR1 stabilizers .
22067155	0	calcium	57,64	RyR2	52,56	calcium	RyR2	MESH:D002118	6262	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	FRET detection of calmodulin binding to the cardiac RyR2 calcium release channel .
24417961	0	calcium	104,111	RyR2	61,65	calcium	RyR2	MESH:D002118	6262	Chemical	Gene	activation|nmod|START_ENTITY sensitizes|xcomp|activation sensitizes|dobj|channels channels|amod|END_ENTITY	Stimulation of NOX2 in isolated hearts reversibly sensitizes RyR2 channels to activation by cytoplasmic calcium .
3162911	0	calcium	134,141	S-100	125,130	calcium	S-100	MESH:D002118	6285	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	Cloning of the sequences expressed abundantly in established cell lines : identification of a cDNA clone highly homologous to S-100 , a calcium binding protein .
3162911	5	calcium	1041,1048	S-100	953,958	calcium	S-100	MESH:D002118	6285	Chemical	Gene	proteins|compound|START_ENTITY family|nmod|proteins belonging|nmod|family protein|acl|belonging protein|appos|protein protein|compound|END_ENTITY	pEL98 protein is highly homologous to both alpha and beta subunits of bovine S-100 protein -LRB- 49 and 47 % homology , respectively -RRB- , a protein belonging to the family of calcium binding proteins .
3742664	0	calcium	10,17	S-100	45,50	calcium	S-100	MESH:D002118	6285	Chemical	Gene	Effect|nmod|START_ENTITY ions|nsubj|Effect ions|nmod|interaction interaction|nmod|protein protein|compound|END_ENTITY	Effect of calcium ions on the interaction of S-100 protein with microtubule proteins .
651877	0	calcium	18,25	S-100	48,53	calcium	S-100	MESH:D002118	6285	Chemical	Gene	fractions|compound|START_ENTITY fractions|compound|END_ENTITY	-LSB- Reaction between calcium and different protein S-100 fractions -RSB- .
11248353	0	calcium	26,33	S100A1	42,48	calcium	S100A1	MESH:D002118	480141(Tax:9615)	Chemical	Gene	Immunolocalization|nmod|START_ENTITY binding|nsubj|Immunolocalization binding|dobj|proteins proteins|compound|END_ENTITY	Immunolocalization of the calcium binding S100A1 , S100A5 and S100A6 proteins in the dog cochlea during postnatal development .
11377420	0	calcium	62,69	S100A1	0,6	calcium	S100A1	MESH:D002118	100348753(Tax:9986)	Chemical	Gene	activation|compound|START_ENTITY desensitizing|dobj|activation modulates|advcl|desensitizing modulates|nsubj|END_ENTITY	S100A1 modulates skeletal muscle contraction by desensitizing calcium activation of isometric tension , stiffness and ATPase .
15885104	0	calcium	31,38	S100A1	12,18	calcium	S100A1	MESH:D002118	6271	Chemical	Gene	protein|nmod|START_ENTITY protein|nummod|END_ENTITY	Affinity of S100A1 protein for calcium increases dramatically upon glutathionylation .
16919727	0	calcium	17,24	S100A1	0,6	calcium	S100A1	MESH:D002118	100348753(Tax:9986)	Chemical	Gene	decreases|dobj|START_ENTITY decreases|nsubj|END_ENTITY	S100A1 decreases calcium spark frequency and alters their spatial characteristics in permeabilized adult ventricular cardiomyocytes .
20686070	0	calcium	43,50	S100A1	0,6	calcium	S100A1	MESH:D002118	20193(Tax:10090)	Chemical	Gene	flux|amod|START_ENTITY promotes|dobj|flux promotes|nsubj|END_ENTITY	S100A1 promotes action potential-initiated calcium release flux and force production in skeletal muscle .
23351007	0	calcium	10,17	S100A1	46,52	calcium	S100A1	MESH:D002118	6271	Chemical	Gene	Impact|nmod|START_ENTITY Impact|nmod|protein protein|compound|END_ENTITY	Impact of calcium binding and thionylation of S100A1 protein on its nuclear magnetic resonance-derived structure and backbone dynamics .
15665453	0	calcium	2,9	S100A4	27,33	calcium	S100A4	MESH:D002118	24615(Tax:10116)	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	A calcium binding protein , S100A4 , mediates T cell dependent cytotoxicity as a transformation-associated antigen .
17219414	0	calcium	63,70	S100A4	56,62	calcium	S100A4	MESH:D002118	6275	Chemical	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	DNA methylation and immunohistochemical analysis of the S100A4 calcium binding protein in human prostate_cancer .
9703888	0	calcium	14,21	S100A4	0,6	calcium	S100A4	MESH:D002118	6275	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|dep|protein	S100A4 -LRB- MTS1 -RRB- calcium binding protein in cancer growth , invasion and metastasis .
10913138	0	calcium	47,54	S100A6	0,6	calcium	S100A6	MESH:D002118	6277	Chemical	Gene	targets|nmod|START_ENTITY targets|nsubj|END_ENTITY	S100A6 and S100A11 are specific targets of the calcium - and zinc-binding S100B protein in vivo .
11108968	0	calcium	10,17	S100A6	0,6	calcium	S100A6	MESH:D002118	20200(Tax:10090)	Chemical	Gene	protein|amod|START_ENTITY END_ENTITY|appos|protein	S100A6 , a calcium - and zinc-binding protein , is overexpressed in SOD1 mutant mice , a model for amyotrophic_lateral_sclerosis .
11937060	0	calcium	77,84	S100A6	22,28	calcium	S100A6	MESH:D002118	6277	Chemical	Gene	mechanism|compound|START_ENTITY states|dep|mechanism structures|dep|states structures|nmod|END_ENTITY	Crystal structures of S100A6 in the Ca -LRB- 2 + -RRB- - free and Ca -LRB- 2 + -RRB- - bound states : the calcium sensor mechanism of S100 proteins revealed at atomic resolution .
22982625	0	calcium	16,23	S100A6	41,47	calcium	S100A6	MESH:D002118	20200(Tax:10090)	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Upregulation of calcium binding protein , S100A6 , in activated astrocytes is linked to glutamate toxicity .
11312263	0	calcium	53,60	S100B	79,84	calcium	S100B	MESH:D002118	25742(Tax:10116)	Chemical	Gene	protein|amod|START_ENTITY protein|compound|END_ENTITY	The giant protein AHNAK is a specific target for the calcium - and zinc-binding S100B protein : potential implications for Ca2 + homeostasis regulation by S100B .
16444689	0	calcium	14,21	S100RVP	37,44	calcium	S100RVP	MESH:D002118	295176(Tax:10116)	Chemical	Gene	Regulation|nmod|START_ENTITY homeostasis|nsubj|Regulation homeostasis|nmod|END_ENTITY	Regulation of calcium homeostasis by S100RVP , an androgen-regulated S100 protein in the rat ventral prostate .
1315768	0	calcium	21,28	S100_beta	0,9	calcium	S100 beta	MESH:D002118	6285	Chemical	Gene	fluxes|compound|START_ENTITY stimulates|dobj|fluxes stimulates|nsubj|END_ENTITY	S100_beta stimulates calcium fluxes in glial and neuronal cells .
11578597	0	calcium	27,34	SERCA3	60,66	calcium	SERCA3	MESH:D002118	25391(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|END_ENTITY	Function of SERCA mediated calcium uptake and expression of SERCA3 in cerebral cortex from young and old rats .
15686499	0	calcium	29,36	SIN-1	52,57	calcium	SIN-1	MESH:D002118	79109	Chemical	Gene	homeostasis|compound|START_ENTITY homeostasis|nmod|END_ENTITY	Alteration of cytosolic free calcium homeostasis by SIN-1 : high sensitivity of L-type Ca2 + channels to extracellular oxidative/nitrosative stress in cerebellar granule cells .
2484686	0	calcium	14,21	SIN-1	65,70	calcium	SIN-1	MESH:D002118	79109	Chemical	Gene	influx|compound|START_ENTITY Inhibition|nmod|influx Inhibition|nmod|END_ENTITY	Inhibition of calcium influx in thrombin-stimulated platelets by SIN-1 , an activator of soluble guanylate cyclase .
7530909	0	calcium	52,59	SIN-1	19,24	calcium	SIN-1	MESH:D002118	79109	Chemical	Gene	current|compound|START_ENTITY inhibits|dobj|current inhibits|nsubj|END_ENTITY	Nitric_oxide donor SIN-1 inhibits mammalian cardiac calcium current through cGMP-dependent protein kinase .
10693936	0	calcium	9,16	SNAP-25	51,58	calcium	SNAP-25	MESH:D002118	540853(Tax:9913)	Chemical	Gene	pathways|nsubj|START_ENTITY pathways|xcomp|induce induce|dobj|expression expression|nmod|protein protein|compound|END_ENTITY	Multiple calcium pathways induce the expression of SNAP-25 protein in chromaffin cells .
11830673	0	calcium	44,51	SNAP-25	18,25	calcium	SNAP-25	MESH:D002118	6616	Chemical	Gene	linked|nmod|START_ENTITY linked|nsubjpass|END_ENTITY	The SNARE protein SNAP-25 is linked to fast calcium triggering of exocytosis .
14980208	0	calcium	22,29	SNAP-25	0,7	calcium	SNAP-25	MESH:D002118	6616	Chemical	Gene	dynamics|compound|START_ENTITY modulation|nmod|dynamics modulation|compound|END_ENTITY	SNAP-25 modulation of calcium dynamics underlies differences in GABAergic and glutamatergic responsiveness to depolarization .
20522554	0	calcium	50,57	SNAP-25	11,18	calcium	SNAP-25	MESH:D002118	25012(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY regulates|dobj|channels regulates|nsubj|END_ENTITY	Endogenous SNAP-25 regulates native voltage-gated calcium channels in glutamatergic neurons .
21558797	0	calcium	39,46	SNAP-25	99,106	calcium	SNAP-25	MESH:D002118	25012(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY kinetics|nmod|channels influenced|nsubjpass|kinetics influenced|nmod|END_ENTITY	Inactivation kinetics of voltage-gated calcium channels in glutamatergic neurons are influenced by SNAP-25 .
22119397	0	calcium	21,28	SNAP-25	114,121	calcium	SNAP-25	MESH:D002118	20614(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|nmod|expression expression|nmod|END_ENTITY	Presynaptic residual calcium and synaptic facilitation at hippocampal synapses of mice with altered expression of SNAP-25 .
9756338	0	calcium	14,21	SNAP-25	52,59	calcium	SNAP-25	MESH:D002118	25012(Tax:10116)	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Intracellular calcium and arachidonic_acid increase SNAP-25 expression in cultured rat hippocampal explants , but not in cultured rat cerebellar explants .
21623665	0	calcium	45,52	SOD1	74,78	calcium	SOD1	MESH:D002118	20655(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|compound|END_ENTITY	Talampanel reduces the level of motoneuronal calcium in transgenic mutant SOD1 mice only if applied presymptomatically .
2271565	0	calcium	11,18	SP-A	22,26	calcium	SP-A	MESH:D002118	653509	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of calcium to SP-A , a surfactant-associated protein .
8593273	5	calcium	933,940	SP-B	1002,1006	calcium	SP-B	MESH:D002118	6439	Chemical	Gene	induced|nsubj|START_ENTITY induced|nmod|END_ENTITY	Calcium caused a small additive increase in lipid mixing , but calcium and SP-A combined markedly increased lipid mixing induced by SP-B .
2322281	0	calcium	18,25	SPARC	47,52	calcium	SPARC	MESH:D002118	24791(Tax:10116)	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Purification of a calcium binding protein -LRB- rat SPARC -RRB- from primary Sertoli cell-enriched culture medium .
18562702	0	calcium	107,114	SRC	54,57	calcium	SRC	MESH:D002118	6714	Chemical	Gene	presence|nmod|START_ENTITY pathway|nmod|presence kinase|nmod|pathway kinase|dobj|END_ENTITY	Increased activity of the human sperm tyrosine kinase SRC by the cAMP-dependent pathway in the presence of calcium .
16987424	0	calcium	39,46	STIM1	15,20	calcium	STIM1	MESH:D002118	6786	Chemical	Gene	activation|compound|START_ENTITY operated|dobj|activation operated|nsubj|role role|nmod|END_ENTITY	A key role for STIM1 in store operated calcium channel activation in airway smooth muscle .
17299780	0	calcium	16,23	STIM1	46,51	calcium	STIM1	MESH:D002118	6786	Chemical	Gene	entry|compound|START_ENTITY correlates|nsubj|entry correlates|nmod|translocation translocation|compound|END_ENTITY	Agonist-induced calcium entry correlates with STIM1 translocation .
18327260	0	calcium	45,52	STIM1	61,66	calcium	STIM1	MESH:D002118	20866(Tax:10090)	Chemical	Gene	functions|nmod|START_ENTITY sensors|nsubj|functions sensors|dobj|END_ENTITY	Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance .
18337241	0	calcium	38,45	STIM1	15,20	calcium	STIM1	MESH:D002118	6786	Chemical	Gene	production|compound|START_ENTITY trigger|nmod|production role|nmod|trigger role|nmod|END_ENTITY	Novel role for STIM1 as a trigger for calcium influx factor production .
18452988	0	calcium	60,67	STIM1	40,45	calcium	STIM1	MESH:D002118	20866(Tax:10090)	Chemical	Gene	influx|compound|START_ENTITY coupled|nmod|influx coupled|nsubjpass|translocation translocation|nmod|END_ENTITY	Reversible translocation of EYFP-tagged STIM1 is coupled to calcium influx in insulin secreting beta-cells .
18488020	0	calcium	41,48	STIM1	0,5	calcium	STIM1	MESH:D002118	20866(Tax:10090)	Chemical	Gene	entry|compound|START_ENTITY controls|dobj|entry controls|nsubj|signalling signalling|compound|END_ENTITY	STIM1 signalling controls store-operated calcium entry required for development and contractile function in skeletal muscle .
18596693	0	calcium	36,43	STIM1	19,24	calcium	STIM1	MESH:D002118	6786	Chemical	Gene	depletion|compound|START_ENTITY ER|dobj|depletion ER|nsubj|Oligomerization Oligomerization|nmod|couples couples|nummod|END_ENTITY	Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation .
19088073	0	calcium	42,49	STIM1	0,5	calcium	STIM1	MESH:D002118	6786	Chemical	Gene	entry|compound|START_ENTITY entry|amod|END_ENTITY	STIM1 - and Orai1-dependent store-operated calcium entry regulates human myoblast differentiation .
19364762	0	calcium	55,62	STIM1	13,18	calcium	STIM1	MESH:D002118	361618(Tax:10116)	Chemical	Gene	influx|compound|START_ENTITY influx|amod|END_ENTITY	Evidence for STIM1 - and Orai1-dependent store-operated calcium influx through ICRAC in vascular smooth muscle cells : role in proliferation and migration .
19470709	0	calcium	95,102	STIM1	18,23	calcium	STIM1	MESH:D002118	20866(Tax:10090)	Chemical	Gene	entry|compound|START_ENTITY involvement|nmod|entry Relocalization|dep|involvement Relocalization|nmod|END_ENTITY	Relocalization of STIM1 in mouse oocytes at fertilization : early involvement of store-operated calcium entry .
19622395	0	calcium	119,126	STIM1	69,74	calcium	STIM1	MESH:D002118	6786	Chemical	Gene	entry|compound|START_ENTITY involved|nmod|entry involved|nsubjpass|protein protein|compound|END_ENTITY	Plasma membrane associated membranes -LRB- PAM -RRB- from Jurkat cells contain STIM1 protein is PAM involved in the capacitative calcium entry ?
19765994	0	calcium	11,18	STIM1	0,5	calcium	STIM1	MESH:D002118	6786	Chemical	Gene	sensor|compound|START_ENTITY sensor|nsubj|END_ENTITY	STIM1 is a calcium sensor specialized for digital signaling .
19881501	0	calcium	65,72	STIM1	19,24	calcium	STIM1	MESH:D002118	6786	Chemical	Gene	entry|compound|START_ENTITY suppression|nmod|entry underlies|dobj|suppression underlies|nsubj|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation of STIM1 underlies suppression of store-operated calcium entry during mitosis .
20037597	0	calcium	31,38	STIM1	0,5	calcium	STIM1	MESH:D002118	6786	Chemical	Gene	ORAI1|compound|START_ENTITY gates|dep|ORAI1 gates|nummod|END_ENTITY	STIM1 gates the store-operated calcium channel ORAI1 in vitro .
20736304	0	calcium	73,80	STIM1	19,24	calcium	STIM1	MESH:D002118	6786	Chemical	Gene	entry|compound|START_ENTITY modulates|dobj|entry modulates|nsubj|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation of STIM1 at ERK1/2 target sites modulates store-operated calcium entry .
20929812	0	calcium	73,80	STIM1	27,32	calcium	STIM1	MESH:D002118	6786	Chemical	Gene	channels|compound|START_ENTITY binds|dobj|channels binds|nsubj|END_ENTITY	The CRAC channel activator STIM1 binds and inhibits L-type voltage-gated calcium channels .
20929813	0	calcium	4,11	STIM1	26,31	calcium	STIM1	MESH:D002118	6786	Chemical	Gene	sensor|compound|START_ENTITY sensor|appos|END_ENTITY	The calcium store sensor , STIM1 , reciprocally controls Orai and CaV1 .2 channels .
21176846	5	calcium	842,849	STIM1	896,901	calcium	Orai1	MESH:D002118	84876	Chemical	Gene	influx|compound|START_ENTITY importance|nmod|influx confirmed|nsubjpass|importance confirmed|nmod|mice mice|acl|lacking lacking|dobj|END_ENTITY	The importance of store-operated calcium influx in muscle is confirmed in mice lacking STIM1 which die perinatally and in patients with mutations on STIM1 or Orai1 who exhibit a myopathy exhibited by hypotonia .
21418512	0	calcium	15,22	STIM1	105,110	calcium	STIM1	MESH:D002118	20866(Tax:10090)	Chemical	Gene	entry|compound|START_ENTITY remains|nsubj|entry remains|nmod|decline decline|nmod|expression expression|compound|END_ENTITY	Store-operated calcium entry remains fully functional in aged mouse skeletal muscle despite a decline in STIM1 protein expression .
21541286	0	calcium	57,64	STIM1	23,28	calcium	STIM1	MESH:D002118	361618(Tax:10116)	Chemical	Gene	entry|compound|START_ENTITY roles|nmod|entry roles|nmod|END_ENTITY	Differential roles for STIM1 and STIM2 in store-operated calcium entry in rat neurons .
22223729	0	calcium	106,113	STIM1	65,70	calcium	STIM1	MESH:D002118	361618(Tax:10116)	Chemical	Gene	influx|compound|START_ENTITY operated|dobj|influx operated|nsubj|role role|nmod|store store|compound|END_ENTITY	Urotensin-II signaling mechanism in rat coronary artery : role of STIM1 and Orai1-dependent store operated calcium influx in vasoconstriction .
22506990	0	calcium	16,23	STIM1	111,116	calcium	STIM1	MESH:D002118	6786	Chemical	Gene	entry|compound|START_ENTITY regulate|dobj|entry regulate|nmod|association association|nmod|END_ENTITY	Homers regulate calcium entry and aggregation in human platelets : a role for Homers in the association between STIM1 and Orai1 .
22546859	0	calcium	16,23	STIM1	0,5	calcium	STIM1	MESH:D002118	20866(Tax:10090)	Chemical	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	STIM1 regulates calcium signaling in taste bud cells and preference for fat in mice .
22712562	0	calcium	38,45	STIM1	0,5	calcium	STIM1	MESH:D002118	6786	Chemical	Gene	entry|compound|START_ENTITY necessary|nmod|entry necessary|nsubj|END_ENTITY	STIM1 is necessary for store-operated calcium entry in turning growth cones .
22992728	0	calcium	91,98	STIM1	16,21	calcium	STIM1	MESH:D002118	6786	Chemical	Gene	entry|compound|START_ENTITY attenuates|dobj|entry attenuates|nsubj|Modification Modification|nmod|END_ENTITY	Modification of STIM1 by O-linked N-acetylglucosamine -LRB- O-GlcNAc -RRB- attenuates store-operated calcium entry in neonatal cardiomyocytes .
23022228	0	calcium	78,85	STIM1	45,50	calcium	STIM1	MESH:D002118	6786	Chemical	Gene	entry|compound|START_ENTITY suppresses|dobj|entry suppresses|nsubj|Knockdown Knockdown|nmod|stromal_interaction_molecule_1 stromal_interaction_molecule_1|appos|END_ENTITY	Knockdown of stromal_interaction_molecule_1 -LRB- STIM1 -RRB- suppresses store-operated calcium entry , cell proliferation and tumorigenicity in human epidermoid_carcinoma A431 cells .
23395841	0	calcium	156,163	STIM1	61,66	calcium	STIM1	MESH:D002118	6786	Chemical	Gene	essential|nmod|START_ENTITY essential|nsubj|domain domain|nmod|END_ENTITY	The polybasic lysine-rich domain of plasma membrane-resident STIM1 is essential for the modulation of store-operated divalent cation entry by extracellular calcium .
23851458	0	calcium	61,68	STIM1	22,27	calcium	STIM1	MESH:D002118	20866(Tax:10090)	Chemical	Gene	entry|compound|START_ENTITY regulator|nmod|entry activation|appos|regulator activation|nmod|END_ENTITY	Initial activation of STIM1 , the regulator of store-operated calcium entry .
24095720	0	calcium	95,102	STIM1	14,19	calcium	STIM1	MESH:D002118	6786	Chemical	Gene	entry|compound|START_ENTITY inhibition|nmod|entry underlies|dobj|inhibition underlies|nsubj|Inhibition Inhibition|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Inhibition of STIM1 phosphorylation underlies resveratrol-induced inhibition of store-operated calcium entry .
24114840	0	calcium	121,128	STIM1	74,79	calcium	STIM1	MESH:D002118	6786	Chemical	Gene	entry|compound|START_ENTITY implication|nmod|entry phosphorylation|dep|implication phosphorylation|nmod|protein protein|appos|END_ENTITY	17b-Estradiol inhibits phosphorylation of stromal_interaction_molecule_1 -LRB- STIM1 -RRB- protein : implication for store-operated calcium entry and chronic lung_diseases .
24289807	0	calcium	40,47	STIM1	20,25	calcium	STIM1	MESH:D002118	779419(Tax:8355)	Chemical	Gene	entry|compound|START_ENTITY role|nmod|entry role|nmod|END_ENTITY	A critical role for STIM1 in filopodial calcium entry and axon guidance .
24493668	0	calcium	6,13	STIM1	0,5	calcium	STIM1	MESH:D002118	20866(Tax:10090)	Chemical	Gene	sensor|compound|START_ENTITY sensor|nummod|END_ENTITY	STIM1 calcium sensor is required for activation of the phagocyte oxidase during inflammation and host defense .
24509424	0	calcium	139,146	STIM1	15,20	calcium	STIM1	MESH:D002118	361618(Tax:10116)	Chemical	Gene	apoptosis|amod|START_ENTITY inhibiting|dobj|apoptosis attenuates|advcl|inhibiting attenuates|nsubj|Suppression Suppression|nmod|END_ENTITY	Suppression of STIM1 in the early stage after global ischemia attenuates the injury of delayed neuronal_death by inhibiting store-operated calcium entry-induced apoptosis in rats .
25190815	0	calcium	74,81	STIM1	32,37	calcium	STIM1	MESH:D002118	6786	Chemical	Gene	entry|compound|START_ENTITY mediate|dobj|entry mediate|nsubj|Stromal_interaction_molecule_1 Stromal_interaction_molecule_1|appos|END_ENTITY	Stromal_interaction_molecule_1 -LRB- STIM1 -RRB- and Orai1 mediate histamine-evoked calcium entry and nuclear factor of activated T-cells -LRB- NFAT -RRB- signaling in human umbilical vein endothelial cells .
25471906	0	calcium	48,55	STIM1	0,5	calcium	STIM1	MESH:D002118	20866(Tax:10090)	Chemical	Gene	entry|compound|START_ENTITY regulate|dobj|entry regulate|nsubj|END_ENTITY	STIM1 , STIM2 , and Orai1 regulate store-operated calcium entry and purinergic activation of microglia .
26560041	0	calcium	51,58	STIM1	13,18	calcium	STIM1	MESH:D002118	6786	Chemical	Gene	entry|compound|START_ENTITY impairs|dobj|entry impairs|nsubj|mutation mutation|compound|END_ENTITY	A homozygous STIM1 mutation impairs store-operated calcium entry and natural killer cell effector function without clinical immunodeficiency .
26826124	0	calcium	114,121	STIM1	88,93	calcium	STIM1	MESH:D002118	6786	Chemical	Gene	entry|compound|START_ENTITY entry|amod|END_ENTITY	T_cell_receptor-induced NF-kB signaling and transcriptional activation are regulated by STIM1 - and Orai1-mediated calcium entry .
27068144	0	calcium	77,84	STIM1	34,39	calcium	STIM1	MESH:D002118	20866(Tax:10090)	Chemical	Gene	entry|compound|START_ENTITY modulate|dobj|entry interaction|acl|modulate interaction|nmod|SARAF SARAF|nmod|END_ENTITY	Dynamic interaction of SARAF with STIM1 and Orai1 to modulate store-operated calcium entry .
20620874	0	calcium	25,32	SV2	0,3	calcium	SV2	MESH:D002118	9900	Chemical	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	SV2 acts via presynaptic calcium to regulate neurotransmitter release .
11347807	0	calcium	22,29	Somatostatin	0,12	calcium	Somatostatin	MESH:D002118	24797(Tax:10116)	Chemical	Gene	influx|compound|START_ENTITY inhibits|dobj|influx inhibits|nsubj|END_ENTITY	Somatostatin inhibits calcium influx into rat rod bipolar cell axonal terminals .
1360185	0	calcium	51,58	Somatostatin	0,12	calcium	Somatostatin	MESH:D002118	24797(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY inhibits|dobj|channels inhibits|nsubj|END_ENTITY	Somatostatin inhibits the norepinephrine-activated calcium channels in rMTC 6-23 cells : possible involvement of a pertussis toxin-sensitive G-protein .
1970502	0	calcium	27,34	Somatostatin	0,12	calcium	Somatostatin	MESH:D002118	100730851	Chemical	Gene	inward|nsubj|START_ENTITY decreases|ccomp|inward decreases|nsubj|END_ENTITY	Somatostatin decreases the calcium inward current in guinea-pig atria .
20972944	0	calcium	37,44	Somatostatin	0,12	calcium	Somatostatin	MESH:D002118	6750	Chemical	Gene	metabolism|compound|START_ENTITY affect|dobj|metabolism affect|nsubj|analogues analogues|compound|END_ENTITY	Somatostatin analogues do not affect calcium metabolism in patients with acromegaly and primary_hyperparathyroidism -LSB- corrected -RSB- due to MEN_1-like syndrome .
2430073	0	calcium	71,78	Somatostatin	0,12	calcium	Somatostatin	MESH:D002118	20604(Tax:10090)	Chemical	Gene	decreases|dobj|START_ENTITY decreases|nsubj|END_ENTITY	Somatostatin , an inhibitor of ACTH secretion , decreases cytosolic free calcium and voltage-dependent calcium current in a pituitary cell line .
2479736	0	calcium	22,29	Somatostatin	0,12	calcium	Somatostatin	MESH:D002118	24797(Tax:10116)	Chemical	Gene	current|compound|START_ENTITY blocks|dobj|current blocks|nsubj|END_ENTITY	Somatostatin blocks a calcium current in rat sympathetic ganglion neurones .
2574619	0	calcium	53,60	Somatostatin	0,12	calcium	Somatostatin	MESH:D002118	24797(Tax:10116)	Chemical	Gene	currents|compound|START_ENTITY types|nmod|currents inhibits|dobj|types inhibits|nsubj|END_ENTITY	Somatostatin inhibits two types of voltage-activated calcium currents in rat growth-hormone secreting cells .
2864719	0	calcium	28,35	Somatostatin	0,12	calcium	Somatostatin	MESH:D002118	24797(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY transport|compound|END_ENTITY	Somatostatin and intestinal calcium transport in the rat .
2892154	0	calcium	22,29	Somatostatin	0,12	calcium	Somatostatin	MESH:D002118	24797(Tax:10116)	Chemical	Gene	current|compound|START_ENTITY blocks|dobj|current blocks|nsubj|END_ENTITY	Somatostatin blocks a calcium current in acutely isolated adult rat superior cervical ganglion neurons .
80623	0	calcium	31,38	Somatostatin	0,12	calcium	Somatostatin	MESH:D002118	6750	Chemical	Gene	excretion|compound|START_ENTITY decreases|dobj|excretion decreases|nsubj|END_ENTITY	Somatostatin decreases urinary calcium excretion .
24427308	0	calcium	13,20	Sorcin	0,6	calcium	Sorcin	MESH:D002118	109552(Tax:10090)	Chemical	Gene	links|dobj|START_ENTITY links|nsubj|END_ENTITY	Sorcin links calcium signaling to vesicle trafficking , regulates Polo-like_kinase_1 and is necessary for mitosis .
25197934	0	calcium	10,17	Sorcin	0,6	calcium	Sorcin	MESH:D002118	6717	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	Sorcin , a calcium binding protein involved in the multidrug resistance mechanisms in cancer cells .
10506191	0	calcium	50,57	Src	17,20	calcium	Src	MESH:D002118	6714	Chemical	Gene	release|compound|START_ENTITY initiating|dobj|release kinase|advcl|initiating kinase|nsubj|Requirement Requirement|nmod|family family|compound|END_ENTITY	Requirement of a Src family kinase for initiating calcium release at fertilization in starfish eggs .
11053438	0	calcium	14,21	Src	74,77	calcium	Src	MESH:D002118	83805(Tax:10116)	Chemical	Gene	mobilization|compound|START_ENTITY induces|nsubj|mobilization induces|dobj|pip92 pip92|nmod|END_ENTITY	Intracellular calcium mobilization induces immediate early gene pip92 via Src and mitogen-activated protein kinase in immortalized hippocampal cells .
12127058	0	calcium	19,26	Src	0,3	calcium	Src	MESH:D002118	380430(Tax:8355)	Chemical	Gene	release|compound|START_ENTITY induces|dobj|release induces|nsubj|kinase kinase|compound|END_ENTITY	Src kinase induces calcium release in Xenopus egg extracts via PLCgamma and IP3-dependent mechanism .
14507968	0	calcium	64,71	Src	107,110	calcium	Src	MESH:D002118	83805(Tax:10116)	Chemical	Gene	increase|compound|START_ENTITY NMDA|dobj|increase NMDA|nmod|activation activation|nmod|family family|compound|END_ENTITY	Interleukin-1beta enhances NMDA receptor-mediated intracellular calcium increase through activation of the Src family of kinases .
15036602	0	calcium	89,96	Src	109,112	calcium	Src	MESH:D002118	83805(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY channel|nmod|END_ENTITY	Activation of ERK5 is mediated by N-methyl-D-aspartate receptor and L-type voltage-gated calcium channel via Src involving oxidative stress after cerebral_ischemia in rat hippocampus .
16123104	0	calcium	95,102	Src	15,18	calcium	Src	MESH:D002118	83805(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY facilitation|nmod|channels tyrosine|nmod|facilitation tyrosine|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of Src tyrosine kinase and mitogen-activated protein kinase in the facilitation of calcium channels in rat nucleus of the tractus solitarius by angiotensin_II .
17942635	0	calcium	49,56	Src	80,83	calcium	Src	MESH:D002118	6714	Chemical	Gene	channel|compound|START_ENTITY association|nmod|channel 1.2|nsubj|association 1.2|dobj|b b|nmod|domains domains|amod|kinase kinase|amod|END_ENTITY	COOH-terminal association of human smooth muscle calcium channel Ca -LRB- v -RRB- 1.2 b with Src kinase protein binding domains : effect of nitrotyrosylation .
19758698	0	calcium	44,51	Src	28,31	calcium	Src	MESH:D002118	6714	Chemical	Gene	mobilization|compound|START_ENTITY mobilization|compound|END_ENTITY	Therapeutic implications of Src independent calcium mobilization in diffuse large B-cell_lymphoma .
20456010	0	calcium	36,43	Src	15,18	calcium	Src	MESH:D002118	20779(Tax:10090)	Chemical	Gene	kinase|nmod|START_ENTITY kinase|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of Src kinase in T-type calcium channel-dependent neuronal differentiation of NG108-15 cells by hydrogen_sulfide .
21872572	0	calcium	52,59	Src	0,3	calcium	Src	MESH:D002118	6714	Chemical	Gene	current|compound|START_ENTITY modulate|dobj|current modulate|nsubj|kinases kinases|compound|END_ENTITY	Src family protein tyrosine kinases modulate L-type calcium current in human atrial myocytes .
24269904	0	calcium	47,54	Src	14,17	calcium	Src	MESH:D002118	380430(Tax:8355)	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of Src and release of intracellular calcium by phosphatidic_acid during Xenopus_laevis fertilization .
22922879	0	calcium	28,35	StCDPK3	62,69	calcium	StCDPK3	MESH:D002118	102577907	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	The novel Solanum_tuberosum calcium dependent protein kinase , StCDPK3 , is expressed in actively growing organs .
16807233	0	calcium	110,117	Stim1	126,131	calcium	Stim1	MESH:D002118	6786	Chemical	Gene	sensor|compound|START_ENTITY sensor|appos|END_ENTITY	Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor , Stim1 .
16807233	0	calcium	21,28	Stim1	126,131	calcium	Stim1	MESH:D002118	6786	Chemical	Gene	selective|nsubj|START_ENTITY selective|nmod|sensor sensor|appos|END_ENTITY	Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor , Stim1 .
17218358	0	calcium	112,119	Stim1	50,55	calcium	Stim1	MESH:D002118	6786	Chemical	Gene	oscillations|compound|START_ENTITY proteins|nmod|oscillations proteins|dobj|END_ENTITY	Role of the store-operated calcium entry proteins Stim1 and Orai1 in muscarinic cholinergic receptor-stimulated calcium oscillations in human embryonic kidney cells .
17218358	0	calcium	27,34	Stim1	50,55	calcium	Stim1	MESH:D002118	6786	Chemical	Gene	entry|compound|START_ENTITY Role|nmod|entry proteins|nsubj|Role proteins|dobj|END_ENTITY	Role of the store-operated calcium entry proteins Stim1 and Orai1 in muscarinic cholinergic receptor-stimulated calcium oscillations in human embryonic kidney cells .
22108917	0	calcium	41,48	Stim1	0,5	calcium	Stim1	MESH:D002118	361618(Tax:10116)	Chemical	Gene	entry|compound|START_ENTITY entry|amod|END_ENTITY	Stim1 - and Orai1-mediated store-operated calcium entry is critical for angiotensin_II-induced vascular smooth muscle cell proliferation .
9392439	0	calcium	53,60	Surfactant_protein-A	0,20	calcium	Surfactant protein-A	MESH:D002118	653509	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Surfactant_protein-A receptor-mediated inhibition of calcium signaling in alveolar type II cells .
22773945	0	calcium	14,21	T1R3	0,4	calcium	T1R3	MESH:D002118	83756	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|dep|receptor	T1R3 : a human calcium taste receptor .
16533816	0	calcium	75,82	TH2	119,122	calcium	TH2	MESH:D002118	15111(Tax:10090)	Chemical	Gene	response|compound|START_ENTITY response|nmod|lymphocytes lymphocytes|nummod|END_ENTITY	The cGMP/protein kinase G pathway contributes to dihydropyridine-sensitive calcium response and cytokine production in TH2 lymphocytes .
17535806	0	calcium	20,27	TLR-4	0,5	calcium	TLR-4	MESH:D002118	21898(Tax:10090)	Chemical	Gene	agonists|compound|START_ENTITY agonists|compound|END_ENTITY	TLR-4 and sustained calcium agonists synergistically produce eicosanoids independent of protein synthesis in RAW264 .7 cells .
23045603	0	calcium	35,42	TLR4	0,4	calcium	TLR4	MESH:D002118	21898(Tax:10090)	Chemical	Gene	activation|nmod|START_ENTITY activation|nummod|END_ENTITY	TLR4 activation of TRPC6-dependent calcium signaling mediates endotoxin-induced lung vascular permeability and inflammation .
24420770	0	calcium	53,60	TMEM16A	24,31	calcium	TMEM16A	MESH:D002118	55107	Chemical	Gene	channel|nmod|START_ENTITY channel|appos|END_ENTITY	Activation of the Ano1 -LRB- TMEM16A -RRB- chloride channel by calcium is not mediated by calmodulin .
10843712	0	calcium	11,18	TNF-alpha	102,111	calcium	TNF-alpha	MESH:D002118	7124	Chemical	Gene	Release|nmod|START_ENTITY regulates|nsubj|Release regulates|dobj|production production|amod|END_ENTITY	Release of calcium from inositol_1 ,4,5 - trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages .
14708348	0	calcium	75,82	TNF-alpha	19,28	calcium	TNF-alpha	MESH:D002118	7124	Chemical	Gene	-RSB-|compound|START_ENTITY involvement|nmod|-RSB- induces|parataxis|involvement induces|dobj|production production|amod|END_ENTITY	-LSB- HIV-1 Tat induces TNF-alpha production by human monocytes : involvement of calcium and PKC pathways -RSB- .
15661163	0	calcium	73,80	TNF-alpha	153,162	calcium	TNF-alpha	MESH:D002118	7124	Chemical	Gene	increase|compound|START_ENTITY increase|acl:relcl|requires requires|dobj|receptors receptors|dep|involvement involvement|nmod|production production|amod|END_ENTITY	Human_immunodeficiency_virus_type_1 Tat protein induces an intracellular calcium increase in human monocytes that requires DHP receptors : involvement in TNF-alpha production .
15733870	0	calcium	53,60	TNF-alpha	11,20	calcium	TNF-alpha	MESH:D002118	7124	Chemical	Gene	influx|compound|START_ENTITY operated|dobj|influx operated|nsubj|store store|compound|END_ENTITY	Persistent TNF-alpha exposure impairs store operated calcium influx in CD4 + T lymphocytes .
15972386	0	calcium	52,59	TNF-alpha	16,25	calcium	TNF-alpha	MESH:D002118	21926(Tax:10090)	Chemical	Gene	efflux|compound|START_ENTITY mediate|dobj|efflux mediate|nsubj|END_ENTITY	RANK ligand and TNF-alpha mediate acid-induced bone calcium efflux in vitro .
16026578	0	calcium	25,32	TNF-alpha	63,72	calcium	TNF-alpha	MESH:D002118	21926(Tax:10090)	Chemical	Gene	Stimulation|nmod|START_ENTITY gradient|nsubj|Stimulation gradient|nmod|expressions expressions|amod|END_ENTITY	Stimulation of epidermal calcium gradient loss and increase in TNF-alpha and IL-1alpha expressions by glycolic_acid in murine epidermis .
1666506	0	calcium	51,58	TNF-alpha	37,46	calcium	TNF-alpha	MESH:D002118	7124	Chemical	Gene	level|compound|START_ENTITY effect|nmod|level effect|appos|END_ENTITY	The effect of tumor_necrosis_factor -LRB- TNF-alpha -RRB- on calcium -LRB- Ca2 + -RRB- level .
19625730	0	calcium	46,53	TNF-alpha	25,34	calcium	TNF-alpha	MESH:D002118	36054(Tax:7227)	Chemical	Gene	kinase|compound|START_ENTITY depends|nmod|kinase depends|nsubj|modulation modulation|nmod|END_ENTITY	Clock gene modulation by TNF-alpha depends on calcium and p38 MAP kinase signaling .
19818386	1	calcium	221,228	TNF-alpha	190,199	calcium	TNF-alpha	MESH:D002118	24835(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|appos|END_ENTITY	It is known that application of tumor-necrosis-factor-alpha -LRB- TNF-alpha -RRB- sensitizes neuronal calcium channels for heat stimuli in rat models of neuropathic_pain .
21158068	0	calcium	15,22	TNF-alpha	49,58	calcium	TNF-alpha	MESH:D002118	24835(Tax:10116)	Chemical	Gene	uniporter|compound|START_ENTITY participates|nsubj|uniporter participates|nmod|cardioprotection cardioprotection|amod|END_ENTITY	-LSB- Mitochondrial calcium uniporter participates in TNF-alpha induced cardioprotection in isolated rat hearts subjected to ischemia/reperfusion -RSB- .
9374730	0	calcium	60,67	TNF-alpha	22,31	calcium	TNF-alpha	MESH:D002118	7124	Chemical	Gene	effects|nmod|START_ENTITY effects|amod|END_ENTITY	Mechanisms underlying TNF-alpha effects on agonist-mediated calcium homeostasis in human airway_smooth_muscle cells .
19298454	0	calcium	100,107	TPC1	55,59	calcium	TPC1	MESH:D002118	825655(Tax:3702)	Chemical	Gene	confers|nmod|START_ENTITY confers|nsubj|mutation mutation|nmod|END_ENTITY	The fou2 mutation in the major vacuolar cation channel TPC1 confers tolerance to inhibitory luminal calcium .
1332473	0	calcium	11,18	TRH	81,84	calcium	TRH	MESH:D002118	7200	Chemical	Gene	blockade|compound|START_ENTITY Effects|nmod|blockade Effects|nmod|END_ENTITY	Effects of calcium channel blockade with verapamil on the prolactin responses to TRH , L-dopa , and bromocriptine .
1902061	0	calcium	8,15	TRH	46,49	calcium	TRH	MESH:D002118	25569(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|regulation regulation|nmod|END_ENTITY	Role of calcium in dopaminergic regulation of TRH - and angiotensin_II-stimulated prolactin release .
6812433	0	calcium	23,30	TRH	0,3	calcium	TRH	MESH:D002118	22044(Tax:10090)	Chemical	Gene	mobilizes|dobj|START_ENTITY mobilizes|nsubj|END_ENTITY	TRH mobilizes membrane calcium in thyrotropic cells as monitored by chlortetracycline .
23662076	0	calcium	6,13	TRPC1	29,34	calcium	TRPC1	MESH:D002118	7220	Chemical	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Serum calcium levels , TRPM7 , TRPC1 , microcalcifications , and breast_cancer using breast imaging reporting and data system scores .
15329338	0	calcium	25,32	TRPC2	48,53	calcium	TRPC2	MESH:D002118	22064(Tax:10090)	Chemical	Gene	influx|compound|START_ENTITY influx|nmod|END_ENTITY	Erythropoietin-modulated calcium influx through TRPC2 is mediated by phospholipase Cgamma and IP3R .
12736256	0	calcium	41,48	TRPC3	0,5	calcium	TRPC3	MESH:D002118	7222	Chemical	Gene	entry|compound|START_ENTITY mediates|dobj|entry mediates|nsubj|END_ENTITY	TRPC3 mediates T-cell receptor-dependent calcium entry in human T-lymphocytes .
15225788	0	calcium	92,99	TRPC3	14,19	calcium	TRPC3	MESH:D002118	7222	Chemical	Gene	entry|compound|START_ENTITY component|nmod|entry component|nsubj|END_ENTITY	Evidence that TRPC3 is a molecular component of the 1alpha ,25 -LRB- OH -RRB- 2D3-activated capacitative calcium entry -LRB- CCE -RRB- in muscle and osteoblast cells .
15709693	0	calcium	38,45	TRPC3	64,69	calcium	TRPC3	MESH:D002118	60395(Tax:10116)	Chemical	Gene	entry|compound|START_ENTITY entry|nmod|protein protein|compound|END_ENTITY	1alpha ,25 -LRB- OH -RRB- 2D3 induces capacitative calcium entry involving a TRPC3 protein in skeletal muscle and osteoblastic cells .
18276585	0	calcium	38,45	TRPC3	0,5	calcium	TRPC3	MESH:D002118	7222	Chemical	Gene	channel|compound|START_ENTITY channel|nsubj|END_ENTITY	TRPC3 is the erythropoietin-regulated calcium channel in human erythroid cells .
18431718	0	calcium	61,68	TRPC3	18,23	calcium	TRPC3	MESH:D002118	7222	Chemical	Gene	stores|compound|START_ENTITY content|nmod|stores reduces|dobj|content reduces|nsubj|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of TRPC3 reduces the content of intracellular calcium stores in HEK-293 cells .
19464259	0	calcium	33,40	TRPC3	15,20	calcium	TRPC3	MESH:D002118	7222	Chemical	Gene	oscillations|compound|START_ENTITY channels|nmod|oscillations channels|nummod|END_ENTITY	Involvement of TRPC3 channels in calcium oscillations mediated by OX -LRB- 1 -RRB- orexin receptors .
21653882	0	calcium	26,33	TRPC3	95,100	calcium	TRPC3	MESH:D002118	7222	Chemical	Gene	coupling|nmod|START_ENTITY permeation|nsubj|coupling permeation|nmod|transient_receptor_potential_canonical_3 transient_receptor_potential_canonical_3|appos|END_ENTITY	PKC-dependent coupling of calcium permeation through transient_receptor_potential_canonical_3 -LRB- TRPC3 -RRB- to calcineurin signaling in HL-1 myocytes .
22566418	0	calcium	69,76	TRPC3	43,48	calcium	TRPC3	MESH:D002118	7222	Chemical	Gene	homeostasis|compound|START_ENTITY mediator|nmod|homeostasis END_ENTITY|dobj|mediator	Williams-Beuren_syndrome_hypercalcemia : is TRPC3 a novel mediator in calcium homeostasis ?
23131343	0	calcium	31,38	TRPC3	94,99	calcium	TRPC3	MESH:D002118	7222	Chemical	Gene	entry|compound|START_ENTITY inhibits|dobj|entry inhibits|nmod|END_ENTITY	Manganese inhibits ATP-induced calcium entry through the transient receptor potential channel TRPC3 in astrocytes .
23948776	0	calcium	109,116	TRPC3	65,70	calcium	TRPC3	MESH:D002118	60395(Tax:10116)	Chemical	Gene	function|compound|START_ENTITY function|amod|voltage-dependent voltage-dependent|dep|END_ENTITY	Enhanced contractility in pregnancy is associated with augmented TRPC3 , L-type , and T-type voltage-dependent calcium channel function in rat uterine radial artery .
24965271	0	calcium	40,47	TRPC3	16,21	calcium	TRPC3	MESH:D002118	60395(Tax:10116)	Chemical	Gene	entry|compound|START_ENTITY Contribution|nmod|entry Contribution|nmod|END_ENTITY	Contribution of TRPC3 to store-operated calcium entry and inflammatory transductions in primary nociceptors .
25908616	0	calcium	42,49	TRPC3	22,27	calcium	TRPC3	MESH:D002118	22065(Tax:10090)	Chemical	Gene	links|dobj|START_ENTITY links|nsubj|channel channel|compound|END_ENTITY	The mutant Moonwalker TRPC3 channel links calcium signaling to lipid metabolism in the developing cerebellum .
16368680	0	calcium	38,45	TRPC5	32,37	calcium	TRPC5	MESH:D002118	7224	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Sensing of lysophospholipids by TRPC5 calcium channel .
17233612	0	calcium	38,45	TRPC5	32,37	calcium	TRPC5	MESH:D002118	7224	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Bipolar phospholipid sensing by TRPC5 calcium channel .
17626205	0	calcium	13,20	TRPC5	36,41	calcium	TRPC5	MESH:D002118	22067(Tax:10090)	Chemical	Gene	influx|compound|START_ENTITY influx|acl|associated associated|advmod|channels channels|nummod|END_ENTITY	Induction of calcium influx through TRPC5 channels by cross-linking of GM1 ganglioside associated with alpha5beta1 integrin initiates neurite outgrowth .
19398778	0	calcium	14,21	TRPC5	61,66	calcium	TRPC5	MESH:D002118	7224	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|channels channels|compound|END_ENTITY	Intracellular calcium strongly potentiates agonist-activated TRPC5 channels .
21980113	0	calcium	10,17	TRPC5	34,39	calcium	TRPC5	MESH:D002118	7224	Chemical	Gene	signals|nsubj|START_ENTITY signals|nmod|END_ENTITY	Balancing calcium signals through TRPC5 and TRPC6 in podocytes .
12351388	0	calcium	105,112	TRPC6	71,76	calcium	TRPC6	MESH:D002118	7225	Chemical	Gene	channel|compound|START_ENTITY forms|dobj|channel forms|nsubj|END_ENTITY	Expression and role of TRPC proteins in human platelets : evidence that TRPC6 forms the store-independent calcium entry channel .
15579537	0	calcium	23,30	TRPC6	93,98	calcium	TRPC6	MESH:D002118	22068(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|homologues homologues|nmod|END_ENTITY	Multiple regulation by calcium of murine homologues of transient receptor potential proteins TRPC6 and TRPC7 expressed in HEK293 cells .
16977347	0	calcium	112,119	TRPC6	0,5	calcium	TRPC6	MESH:D002118	100135637(Tax:10141)	Chemical	Gene	entry|compound|START_ENTITY affecting|dobj|entry inhibits|advcl|affecting inhibits|nsubj|END_ENTITY	TRPC6 silencing in primary airway_smooth_muscle cells inhibits protein expression without affecting OAG-induced calcium entry .
17532549	0	calcium	20,27	TRPC6	14,19	calcium	TRPC6	MESH:D002118	489435(Tax:9615)	Chemical	Gene	channels|compound|START_ENTITY channels|nummod|END_ENTITY	Activation of TRPC6 calcium channels by diacylglycerol -LRB- DAG -RRB- - containing arachidonic_acid : a comparative study with DAG-containing docosahexaenoic_acid .
17684020	0	calcium	86,93	TRPC6	109,114	calcium	TRPC6	MESH:D002118	89823(Tax:10116)	Chemical	Gene	influx|compound|START_ENTITY augments|dobj|influx augments|nmod|END_ENTITY	Snapin , a new regulator of receptor signaling , augments alpha1A-adrenoceptor-operated calcium influx through TRPC6 .
18800249	0	calcium	37,44	TRPC6	147,152	calcium	TRPC6	MESH:D002118	7225	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|nmod|END_ENTITY	VEGF-mediated elevated intracellular calcium and angiogenesis in human microvascular endothelial cells in vitro are inhibited by dominant negative TRPC6 .
23976973	0	calcium	29,36	TRPC6	94,99	calcium	TRPC6	MESH:D002118	7225	Chemical	Gene	release|compound|START_ENTITY increases|dobj|release increases|nmod|regulation regulation|nmod|END_ENTITY	p53 increases intra-cellular calcium release by transcriptional regulation of calcium channel TRPC6 in GaQ3-treated cancer cells .
24462772	0	calcium	56,63	TRPC6	0,5	calcium	TRPC6	MESH:D002118	22068(Tax:10090)	Chemical	Gene	concentration|compound|START_ENTITY regulation|nmod|concentration participates|nmod|regulation participates|nsubj|END_ENTITY	TRPC6 participates in the regulation of cytosolic basal calcium concentration in murine resting platelets .
26239116	0	calcium	44,51	TRPC6	66,71	calcium	TRPC6	MESH:D002118	7225	Chemical	Gene	entry|compound|START_ENTITY regulate|dobj|entry regulate|nmod|END_ENTITY	FKBP25 and FKBP38 regulate non-capacitative calcium entry through TRPC6 .
26392222	0	calcium	25,32	TRPC6	0,5	calcium	TRPC6	MESH:D002118	22068(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY channel|nsubj|END_ENTITY	TRPC6 is the endothelial calcium channel that regulates leukocyte transendothelial_migration during the inflammatory response .
26718737	0	calcium	60,67	TRPC6	0,5	calcium	TRPC6	MESH:D002118	89823(Tax:10116)	Chemical	Gene	elevation|compound|START_ENTITY induced|dobj|elevation required|dep|induced required|nsubj|END_ENTITY	TRPC6 is required for hypoxia - induced basal intracellular calcium concentration elevation , and for the proliferation and migration of rat distal pulmonary venous smooth muscle cells .
16401641	0	calcium	41,48	TRPC7	14,19	calcium	TRPC7	MESH:D002118	57113	Chemical	Gene	channels|nmod|START_ENTITY channels|nummod|END_ENTITY	Protection of TRPC7 cation channels from calcium inhibition by closely associated SERCA pumps .
23452348	0	calcium	59,66	TRPM1	53,58	calcium	TRPM1	MESH:D002118	4308	Chemical	Gene	function|compound|START_ENTITY function|compound|END_ENTITY	Metabotropic glutamate receptor 6 signaling enhances TRPM1 calcium channel function and increases melanin content in human melanocytes .
12594222	0	calcium	31,38	TRPM2	8,13	calcium	TRPM2	MESH:D002118	7226	Chemical	Gene	influx|compound|START_ENTITY inhibits|dobj|influx inhibits|nsubj|isoform isoform|compound|END_ENTITY	A novel TRPM2 isoform inhibits calcium influx and susceptibility to cell death .
15952035	0	calcium	9,16	TRPM2	0,5	calcium	TRPM2	MESH:D002118	7226	Chemical	Gene	influx|compound|START_ENTITY END_ENTITY|dep|influx	TRPM2 : a calcium influx pathway regulated by oxidative stress and the novel second messenger ADP-ribose .
17893195	0	calcium	48,55	TRPM2	14,19	calcium	TRPM2	MESH:D002118	7226	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of TRPM2 by extra - and intracellular calcium .
18442831	0	calcium	27,34	TRPM2	50,55	calcium	TRPM2	MESH:D002118	100761555	Chemical	Gene	influx|compound|START_ENTITY influx|nmod|channels channels|nummod|END_ENTITY	Effects of antioxidants on calcium influx through TRPM2 channels in transfected cells activated by hydrogen_peroxide .
19350103	0	calcium	33,40	TRPM2	27,32	calcium	TRPM2	MESH:D002118	7226	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Role of H -LRB- 2 -RRB- O -LRB- 2 -RRB- - activated TRPM2 calcium channel in oxidant-induced endothelial_injury .
19372375	0	calcium	14,21	TRPM2	32,37	calcium	TRPM2	MESH:D002118	7226	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Intracellular calcium activates TRPM2 and its alternative spliced isoforms .
21135052	0	calcium	41,48	TRPM2	0,5	calcium	TRPM2	MESH:D002118	7226	Chemical	Gene	signalling|compound|START_ENTITY channel|nmod|signalling END_ENTITY|dep|channel	TRPM2 : a multifunctional ion channel for calcium signalling .
24682240	0	calcium	126,133	TRPM2	172,177	calcium	TRPM2	MESH:D002118	294329(Tax:10116)	Chemical	Gene	entry|compound|START_ENTITY triggered|dobj|entry stress|acl|triggered stress|dep|role role|nmod|channels channels|compound|END_ENTITY	Agomelatine and duloxetine synergistically modulates apoptotic pathway by inhibiting oxidative stress triggered intracellular calcium entry in neuronal PC12 cells : role of TRPM2 and voltage-gated calcium channels .
24682240	0	calcium	196,203	TRPM2	172,177	calcium	TRPM2	MESH:D002118	294329(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Agomelatine and duloxetine synergistically modulates apoptotic pathway by inhibiting oxidative stress triggered intracellular calcium entry in neuronal PC12 cells : role of TRPM2 and voltage-gated calcium channels .
27068538	0	calcium	78,85	TRPM2	104,109	calcium	TRPM2	MESH:D002118	7226	Chemical	Gene	remodelling|nmod|START_ENTITY regulation|nmod|remodelling regulation|dep|role role|nmod|channels channels|nummod|END_ENTITY	Reciprocal regulation of actin cytoskeleton remodelling and cell migration by calcium and zinc : role of TRPM2 channels .
21904821	0	calcium	39,46	TRPV1	59,64	calcium	TRPV1	MESH:D002118	83810(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|nmod|END_ENTITY	Calcium-dependent inhibition of T-type calcium channels by TRPV1 activation in rat sensory neurons .
14707014	0	calcium	6,13	TRPV4	0,5	calcium	TRPV4	MESH:D002118	59341	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	TRPV4 calcium entry channel : a paradigm for gating diversity .
18719094	0	calcium	48,55	TRPV4	0,5	calcium	TRPV4	MESH:D002118	63873(Tax:10090)	Chemical	Gene	entry|compound|START_ENTITY participates|nmod|entry participates|nsubj|channel channel|compound|END_ENTITY	TRPV4 channel participates in receptor-operated calcium entry and ciliary beat frequency regulation in mouse airway epithelial cells .
21540339	0	calcium	59,66	TRPV4	42,47	calcium	TRPV4	MESH:D002118	63873(Tax:10090)	Chemical	Gene	influx|compound|START_ENTITY 4|dep|influx 4|appos|END_ENTITY	Transient receptor potential vanilloid 4 -LRB- TRPV4 -RRB- - dependent calcium influx and ATP release in mouse oesophageal keratinocytes .
24906497	0	calcium	63,70	TRPV4	17,22	calcium	TRPV4	MESH:D002118	59341	Chemical	Gene	independent|nmod|START_ENTITY independent|nsubj|Sensitisation Sensitisation|nmod|END_ENTITY	Sensitisation of TRPV4 by PAR2 is independent of intracellular calcium signalling and can be mediated by the biased agonist neutrophil elastase .
26249260	0	calcium	51,58	TRPV4	14,19	calcium	TRPV4	MESH:D002118	59341	Chemical	Gene	results|nmod|START_ENTITY results|nsubj|mutation mutation|nmod|END_ENTITY	A mutation in TRPV4 results in altered chondrocyte calcium signaling in severe metatropic_dysplasia .
26249260	0	calcium	51,58	TRPV4	14,19	calcium	TRPV4	MESH:D002118	59341	Chemical	Gene	results|nmod|START_ENTITY results|nsubj|mutation mutation|nmod|END_ENTITY	A mutation in TRPV4 results in altered chondrocyte calcium signaling in severe metatropic_dysplasia .
26453519	0	calcium	26,33	TRPV4	90,95	calcium	TRPV4	MESH:D002118	63873(Tax:10090)	Chemical	Gene	influx|compound|START_ENTITY involves|nsubj|influx involves|dobj|END_ENTITY	Hydrogen_peroxide-induced calcium influx in lung microvascular endothelial cells involves TRPV4 .
12765695	0	calcium	15,22	TRPV5	33,38	calcium	TRPV5	MESH:D002118	56302	Chemical	Gene	channels|compound|START_ENTITY channels|appos|TRPV6 TRPV6|compound|END_ENTITY	The epithelial calcium channels , TRPV5 _ TRPV6 : from identification towards regulation .
18004496	0	calcium	170,177	TRPV5	14,19	calcium	TRPV5	MESH:D002118	56302	Chemical	Gene	reabsorption|compound|START_ENTITY pathway|nmod|reabsorption contributes|nmod|pathway pH.|ccomp|contributes pH.|nsubj|Regulation Regulation|nmod|activity activity|nummod|END_ENTITY	Regulation of TRPV5 single-channel activity by intracellular pH. The transient receptor potential channel TRPV5 contributes to the apical entry pathway for transcellular calcium reabsorption in the kidney .
18596722	0	calcium	33,40	TRPV5	0,5	calcium	TRPV5	MESH:D002118	56302	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|dep|channel	TRPV5 : an ingeniously controlled calcium channel .
19295174	0	calcium	41,48	TRPV5	25,30	calcium	TRPV5	MESH:D002118	56302	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Endogenous expression of TRPV5 and TRPV6 calcium channels in human leukemia K562 cells .
19885716	0	calcium	16,23	TRPV5	120,125	calcium	TRPV5	MESH:D002118	56302	Chemical	Gene	transport|compound|START_ENTITY monolayer|nsubj|transport monolayer|nmod|knockdown knockdown|nmod|1.3 1.3|amod|END_ENTITY	Transepithelial calcium transport in prolactin-exposed intestine-like Caco-2 monolayer after combinatorial knockdown of TRPV5 , TRPV6 and Ca -LRB- v -RRB- 1.3 .
21737966	0	calcium	34,41	TRPV5	60,65	calcium	TRPV5	MESH:D002118	100034071(Tax:9796)	Chemical	Gene	expression|nmod|START_ENTITY transporter|nsubj|expression transporter|xcomp|genes genes|nummod|END_ENTITY	Tissue-specific expression of the calcium transporter genes TRPV5 , TRPV6 , NCX1 , and PMCA1b in the duodenum , kidney and heart of Equus_caballus .
23383183	0	calcium	87,94	TRPV5	104,109	calcium	TRPV5	MESH:D002118	194352(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Autosomal dominant hypercalciuria in a mouse model due to a mutation of the epithelial calcium channel , TRPV5 .
23747339	0	calcium	39,46	TRPV5	33,38	calcium	TRPV5	MESH:D002118	194352(Tax:10090)	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Post-translational loss of renal TRPV5 calcium channel expression , Ca -LRB- 2 + -RRB- wasting , and bone_loss in experimental colitis .
24434184	0	calcium	21,28	TRPV5	54,59	calcium	TRPV5	MESH:D002118	194352(Tax:10090)	Chemical	Gene	reabsorption|compound|START_ENTITY promotes|dobj|reabsorption promotes|nmod|channel channel|compound|END_ENTITY	FGF23 promotes renal calcium reabsorption through the TRPV5 channel .
24828496	0	calcium	58,65	TRPV5	122,127	calcium	TRPV5	MESH:D002118	56302	Chemical	Gene	channel|compound|START_ENTITY channel|appos|transient_receptor_potential_vanilloid_type_5 transient_receptor_potential_vanilloid_type_5|appos|END_ENTITY	b1-Adrenergic receptor signaling activates the epithelial calcium channel , transient_receptor_potential_vanilloid_type_5 -LRB- TRPV5 -RRB- , via the protein kinase A pathway .
25139832	0	calcium	119,126	TRPV5	13,18	calcium	TRPV5	MESH:D002118	56302	Chemical	Gene	transportation|compound|START_ENTITY regulate|dobj|transportation targeting|advcl|regulate RNA|xcomp|targeting RNA|nsubj|Induction Induction|nmod|expression expression|nummod|END_ENTITY	Induction of TRPV5 expression by small activating RNA targeting gene promoter as a novel approach to regulate cellular calcium transportation .
22354706	0	calcium	12,19	TRPV5/6	4,11	calcium	TRPV5/6	MESH:D002118	56302;55503	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	The TRPV5/6 calcium channels contain multiple calmodulin binding sites with differential binding properties .
12765695	0	calcium	15,22	TRPV6	41,46	calcium	TRPV6	MESH:D002118	55503	Chemical	Gene	channels|compound|START_ENTITY channels|appos|END_ENTITY	The epithelial calcium channels , TRPV5 _ TRPV6 : from identification towards regulation .
16362534	0	calcium	101,108	TRPV6	72,77	calcium	TRPV6	MESH:D002118	55503	Chemical	Gene	channel|compound|START_ENTITY expression|appos|channel END_ENTITY|dobj|expression	1,25-Dihydroxyvitamin _ D and 25-hydroxyvitamin_D -- mediated regulation of TRPV6 -LRB- a putative epithelial calcium channel -RRB- mRNA expression in Caco-2 cells .
18276610	0	calcium	94,101	TRPV6	61,66	calcium	TRPV6	MESH:D002118	55503	Chemical	Gene	formation|compound|START_ENTITY factor|nmod|formation factor|nsubj|haplotype haplotype|nmod|END_ENTITY	Gain-of-function haplotype in the epithelial calcium channel TRPV6 is a risk factor for renal calcium stone formation .
18348695	0	calcium	59,66	TRPV6	16,21	calcium	TRPV6	MESH:D002118	64177(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY involved|nmod|transport involved|nsubjpass|END_ENTITY	Calcium channel TRPV6 is involved in murine maternal-fetal calcium transport .
18701326	0	calcium	14,21	TRPV6	30,35	calcium	TRPV6	MESH:D002118	100137068(Tax:9940)	Chemical	Gene	channel|compound|START_ENTITY Expression|nmod|channel END_ENTITY|nsubj|Expression	Expression of calcium channel TRPV6 in ovine epithelial tissue .
19073913	0	calcium	75,82	TRPV6	0,5	calcium	TRPV6	MESH:D002118	64177(Tax:10090)	Chemical	Gene	absorption|compound|START_ENTITY required|nmod|absorption required|nsubjpass|END_ENTITY	TRPV6 is not required for 1alpha,25-dihydroxyvitamin _ D3-induced intestinal calcium absorption in vivo .
19140341	0	calcium	17,24	TRPV6	11,16	calcium	TRPV6	MESH:D002118	55503	Chemical	Gene	channels|compound|START_ENTITY channels|nummod|END_ENTITY	-LSB- TRPV5 and TRPV6 calcium channels in human T cells -RSB- .
19779013	0	calcium	87,94	TRPV6	53,58	calcium	TRPV6	MESH:D002118	55503	Chemical	Gene	absorption|compound|START_ENTITY involved|nmod|absorption involved|nsubj|responses responses|nmod|metabolites metabolites|nmod|END_ENTITY	Human duodenum responses to vitamin_D metabolites of TRPV6 and other genes involved in calcium absorption .
21737966	0	calcium	34,41	TRPV6	67,72	calcium	TRPV6	MESH:D002118	100055509(Tax:9796)	Chemical	Gene	expression|nmod|START_ENTITY transporter|nsubj|expression transporter|xcomp|genes genes|nummod|END_ENTITY	Tissue-specific expression of the calcium transporter genes TRPV5 , TRPV6 , NCX1 , and PMCA1b in the duodenum , kidney and heart of Equus_caballus .
22589201	0	calcium	146,153	TRPV6	118,123	calcium	TRPV6	MESH:D002118	64177(Tax:10090)	Chemical	Gene	absorption|compound|START_ENTITY increases|dobj|absorption increases|nsubj|expression expression|nmod|member_6 member_6|appos|END_ENTITY	Villin promoter-mediated transgenic expression of transient_receptor_potential_cation_channel , _ subfamily_V , _ member_6 -LRB- TRPV6 -RRB- increases intestinal calcium absorption in wild-type and vitamin_D_receptor knockout mice .
23040501	0	calcium	35,42	TRPV6	51,56	calcium	TRPV6	MESH:D002118	55503	Chemical	Gene	channel|compound|START_ENTITY Inhibition|nmod|channel END_ENTITY|nsubj|Inhibition	Inhibition of the human epithelial calcium channel TRPV6 by 2-aminoethoxydiphenyl_borate -LRB- 2-APB -RRB- .
23681196	6	calcium	1389,1396	TRPV6	1444,1449	calcium	TRPV6	MESH:D002118	55503	Chemical	Gene	absorption|compound|START_ENTITY affect|dobj|absorption affect|dep|increases increases|dobj|expression expression|compound|END_ENTITY	The results obtained point out that : -LRB- i -RRB- CPPs do not affect paracellular calcium absorption ; -LRB- ii -RRB- 1,25 -LRB- OH -RRB- ___ D increases the TRPV6 mRNA expression in both types of cells .
25172921	0	calcium	6,13	TRPV6	0,5	calcium	TRPV6	MESH:D002118	64177(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY channel|nummod|END_ENTITY	TRPV6 calcium channel translocates to the plasma membrane via Orai1-mediated mechanism and controls cancer cell survival .
18768853	0	calcium	10,17	Th2	21,24	calcium	Th2	MESH:D002118	15111(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|cells cells|amod|END_ENTITY	Elevating calcium in Th2 cells activates multiple pathways to induce IL-4 transcription and mRNA stabilization .
20167851	0	calcium	19,26	Th2	50,53	calcium	Th2	MESH:D002118	15111(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY channels|acl|implicated implicated|nmod|activation activation|amod|END_ENTITY	Knocking down Cav1 calcium channels implicated in Th2 cell activation prevents experimental asthma .
10448899	0	calcium	18,25	Thrombin	0,8	calcium	Thrombin	MESH:D002118	2147	Chemical	Gene	releases|dobj|START_ENTITY releases|nsubj|END_ENTITY	Thrombin releases calcium from internal stores of ultraviolet C-treated V79 fibroblasts independent of phosphatidylinositol_bisphosphate hydrolysis : role of oxidative stress .
12039967	0	calcium	89,96	Thrombin	0,8	calcium	Thrombin	MESH:D002118	2147	Chemical	Gene	regulate|dobj|START_ENTITY cells|acl|regulate activate|nmod|cells activate|nsubj|receptors receptors|compound|END_ENTITY	Thrombin receptors activate G -LRB- o -RRB- proteins in endothelial cells to regulate intracellular calcium and cell shape changes .
1316802	0	calcium	27,34	Thrombin	0,8	calcium	Thrombin	MESH:D002118	2147	Chemical	Gene	channels|compound|START_ENTITY stimulates|dobj|channels stimulates|nsubj|END_ENTITY	Thrombin stimulates L-type calcium channels of guinea_pig cardiomyocytes in cell-attached patches but not after intracellular dialysis .
1486937	0	calcium	64,71	Thrombin	0,8	calcium	Thrombin	MESH:D002118	2147	Chemical	Gene	fluxes|compound|START_ENTITY stimulates|dobj|fluxes stimulates|nsubj|END_ENTITY	Thrombin stimulates inositol_phosphate formation , intracellular calcium fluxes and DNA synthesis in cultured fetal human non-pigmented ciliary epithelial cells .
17197525	0	calcium	32,39	Thrombin	0,8	calcium	Thrombin	MESH:D002118	280685(Tax:9913)	Chemical	Gene	propagation|compound|START_ENTITY inhibits|dobj|propagation inhibits|nsubj|END_ENTITY	Thrombin inhibits intercellular calcium wave propagation in corneal endothelial cells by modulation of hemichannels and gap junctions .
1874183	0	calcium	56,63	Thrombin	0,8	calcium	Thrombin	MESH:D002118	29251(Tax:10116)	Chemical	Gene	mobilize|dobj|START_ENTITY mobilize|nsubj|hormone hormone|amod|END_ENTITY	Thrombin and parathyroid hormone mobilize intracellular calcium in rat_osteosarcoma cells by distinct pathways .
2153536	0	calcium	73,80	Thrombin	0,8	calcium	Thrombin	MESH:D002118	29251(Tax:10116)	Chemical	Gene	inositol_phosphate|dobj|START_ENTITY inositol_phosphate|nsubj|stimulates stimulates|compound|END_ENTITY	Thrombin stimulates inositol_phosphate production and intracellular free calcium by a pertussis toxin-insensitive mechanism in osteosarcoma cells .
2555323	0	calcium	19,26	Thrombin	0,8	calcium	Thrombin	MESH:D002118	2147	Chemical	Gene	transient|compound|START_ENTITY induces|dobj|transient induces|nsubj|END_ENTITY	Thrombin induces a calcium transient that mediates an activation of the Na + / H + exchanger in human fibroblasts .
9247061	0	calcium	62,69	Thrombin_receptor	0,17	calcium	Thrombin receptor	MESH:D002118	25439(Tax:10116)	Chemical	Gene	responses|compound|START_ENTITY coupled|dobj|responses neurons|acl|coupled neurons|amod|END_ENTITY	Thrombin_receptor on rat primary hippocampal neurons : coupled calcium and cAMP responses .
1707668	0	calcium	108,115	Thyrotropin-releasing_hormone	0,29	calcium	Thyrotropin-releasing hormone	MESH:D002118	25569(Tax:10116)	Chemical	Gene	involves|dobj|START_ENTITY involves|nsubj|regulation regulation|amod|END_ENTITY	Thyrotropin-releasing_hormone regulation of thyrotropin beta-subunit gene expression involves intracellular calcium and protein kinase C .
2428859	0	calcium	174,181	Thyrotropin-releasing_hormone	0,29	calcium	Thyrotropin-releasing hormone	MESH:D002118	7200	Chemical	Gene	ion|compound|START_ENTITY influx|nmod|ion block|dobj|influx antagonists|acl:relcl|block suppressed|nmod|antagonists suppressed|nsubjpass|stimulation stimulation|amod|END_ENTITY	Thyrotropin-releasing_hormone stimulation of thyrotropin secretion is suppressed by calcium ion antagonists that block transmembrane influx and intracellular mobilization of calcium ion in human subjects .
2428859	0	calcium	84,91	Thyrotropin-releasing_hormone	0,29	calcium	Thyrotropin-releasing hormone	MESH:D002118	7200	Chemical	Gene	antagonists|compound|START_ENTITY suppressed|nmod|antagonists suppressed|nsubjpass|stimulation stimulation|amod|END_ENTITY	Thyrotropin-releasing_hormone stimulation of thyrotropin secretion is suppressed by calcium ion antagonists that block transmembrane influx and intracellular mobilization of calcium ion in human subjects .
3007496	0	calcium	91,98	Thyrotropin-releasing_hormone	0,29	calcium	Thyrotropin-releasing hormone	MESH:D002118	25569(Tax:10116)	Chemical	Gene	elevation|nmod|START_ENTITY elevation|amod|END_ENTITY	Thyrotropin-releasing_hormone -LRB- TRH -RRB- elevation of inositol_trisphosphate and cytosolic free calcium is dependent on receptor number .
3096691	0	calcium	146,153	Thyrotropin-releasing_hormone	0,29	calcium	Thyrotropin-releasing hormone	MESH:D002118	25569(Tax:10116)	Chemical	Gene	elevation|nmod|START_ENTITY regulated|nmod|elevation synergistically|dep|regulated synergistically|nsubj|stimulation stimulation|amod|END_ENTITY	Thyrotropin-releasing_hormone stimulation of prolactin secretion is coordinately but not synergistically regulated by an elevation of cytoplasmic calcium and 1,2-diacylglycerol .
3917906	0	calcium	86,93	Thyrotropin-releasing_hormone	0,29	calcium	Thyrotropin-releasing hormone	MESH:D002118	25569(Tax:10116)	Chemical	Gene	elevation|nmod|START_ENTITY stimulates|dobj|elevation stimulates|nsubj|END_ENTITY	Thyrotropin-releasing_hormone -LRB- TRH -RRB- stimulates biphasic elevation of cytoplasmic free calcium in GH3 cells .
3930223	0	calcium	178,185	Thyrotropin-releasing_hormone	0,29	calcium	Thyrotropin-releasing hormone	MESH:D002118	25569(Tax:10116)	Chemical	Gene	dependency|compound|START_ENTITY used|nmod|dependency that|acl|used differs|nmod|that pathway|acl:relcl|differs stimulate|nmod|pathway stimulate|nsubj|END_ENTITY	Thyrotropin-releasing_hormone and epidermal_growth_factor stimulate prolactin synthesis by a pathway -LRB- s -RRB- that differs from that used by phorbol_esters : dissociation of actions by calcium dependency and additivity .
6787084	0	calcium	145,152	Thyrotropin-releasing_hormone	0,29	calcium	Thyrotropin-releasing hormone	MESH:D002118	25569(Tax:10116)	Chemical	Gene	action|nmod|START_ENTITY evidence|nmod|action stimulation|dep|evidence stimulation|amod|END_ENTITY	Thyrotropin-releasing_hormone stimulation of prolactin release from clonal rat pituitary cells : evidence for action independent of extracellular calcium .
6801036	0	calcium	54,61	Thyrotropin-releasing_hormone	0,29	calcium	Thyrotropin-releasing hormone	MESH:D002118	25569(Tax:10116)	Chemical	Gene	loss|nmod|START_ENTITY causes|dobj|loss causes|nsubj|END_ENTITY	Thyrotropin-releasing_hormone causes loss of cellular calcium without calcium uptake by rat pituitary cells in culture .
6801036	0	calcium	70,77	Thyrotropin-releasing_hormone	0,29	calcium	Thyrotropin-releasing hormone	MESH:D002118	25569(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY causes|nmod|uptake causes|nsubj|END_ENTITY	Thyrotropin-releasing_hormone causes loss of cellular calcium without calcium uptake by rat pituitary cells in culture .
8404612	0	calcium	109,116	Thyrotropin-releasing_hormone	0,29	calcium	Thyrotropin-releasing hormone	MESH:D002118	25569(Tax:10116)	Chemical	Gene	mobilization|compound|START_ENTITY implications|nmod|mobilization stimulates|dep|implications stimulates|amod|END_ENTITY	Thyrotropin-releasing_hormone stimulates c-jun and c-fos messenger ribonucleic_acid levels : implications for calcium mobilization and protein kinase-C activation .
8883898	0	calcium	81,88	Thyrotropin-releasing_hormone	0,29	calcium	Thyrotropin-releasing hormone	MESH:D002118	7200	Chemical	Gene	attenuates|nmod|START_ENTITY attenuates|nsubj|END_ENTITY	Thyrotropin-releasing_hormone -LRB- TRH -RRB- attenuates glutamate-stimulated increases in calcium in primary neuronal_cultures .
15548726	0	calcium	34,41	Titin	0,5	calcium	Titin	MESH:D002118	7273	Chemical	Gene	effect|nmod|START_ENTITY effect|amod|END_ENTITY	Titin isoform-dependent effect of calcium on passive myocardial_tension .
23395171	0	calcium	17,24	Tmem64	0,6	calcium	Tmem64	MESH:D002118	100201(Tax:10090)	Chemical	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	Tmem64 modulates calcium signaling during RANKL-mediated osteoclast differentiation .
19147493	0	calcium	24,31	TonEBP	14,20	calcium	TonEBP	MESH:D002118	54446(Tax:10090)	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of TonEBP by calcium controls -LCB- beta -RCB- 1,3-glucuronosyltransferase-I expression , a key regulator of glycosaminoglycan synthesis in cells of the intervertebral disc .
8462475	0	calcium	44,51	Transforming_growth_factor-beta_1	0,33	calcium	Transforming growth factor-beta 1	MESH:D002118	59086(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY modulates|dobj|metabolism modulates|nsubj|END_ENTITY	Transforming_growth_factor-beta_1 modulates calcium metabolism in Sertoli cells .
21316269	0	calcium	109,116	Trpv4	103,108	calcium	Trpv4	MESH:D002118	66026(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Cerebral arteriogenesis is enhanced by pharmacological as well as fluid-shear-stress activation of the Trpv4 calcium channel .
21670068	0	calcium	32,39	Trpv5/6	0,7	calcium	Trpv5/6	MESH:D002118	100000322(Tax:7955)	Chemical	Gene	uptake|compound|START_ENTITY vital|nmod|uptake vital|nsubj|END_ENTITY	Trpv5/6 is vital for epithelial calcium uptake and bone formation .
17129178	0	calcium	22,29	Trpv6	82,87	calcium	Trpv6	MESH:D002118	64177(Tax:10090)	Chemical	Gene	disturbance|nmod|START_ENTITY homeostasis|nsubj|disturbance homeostasis|nmod|mice mice|nmod|disruption disruption|nmod|gene gene|amod|END_ENTITY	Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel gene .
17129178	0	calcium	88,95	Trpv6	82,87	calcium	Trpv6	MESH:D002118	64177(Tax:10090)	Chemical	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel gene .
20399919	0	calcium	26,33	Trpv6	0,5	calcium	Trpv6	MESH:D002118	64177(Tax:10090)	Chemical	Gene	absorption|compound|START_ENTITY mediates|dobj|absorption mediates|nsubj|END_ENTITY	Trpv6 mediates intestinal calcium absorption during calcium restriction and contributes to bone homeostasis .
20399919	0	calcium	52,59	Trpv6	0,5	calcium	Trpv6	MESH:D002118	64177(Tax:10090)	Chemical	Gene	restriction|compound|START_ENTITY mediates|nmod|restriction mediates|nsubj|END_ENTITY	Trpv6 mediates intestinal calcium absorption during calcium restriction and contributes to bone homeostasis .
22496569	0	calcium	60,67	Tumor_necrosis_factor	0,21	calcium	Tumor necrosis factor	MESH:D002118	103694380	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Tumor_necrosis_factor activation of vagal afferent terminal calcium is blocked by cannabinoids .
19081643	0	calcium	71,78	Tumor_necrosis_factor-alpha	0,27	calcium	Tumor necrosis factor-alpha	MESH:D002118	24835(Tax:10116)	Chemical	Gene	transients|compound|START_ENTITY transients|amod|END_ENTITY	Tumor_necrosis_factor-alpha , interleukin-1beta and nitric_oxide induce calcium transients in distinct populations of cells cultured from the rat area postrema .
19877030	0	calcium	59,66	Tumor_necrosis_factor_alpha	0,27	calcium	Tumor necrosis factor alpha	MESH:D002118	7124	Chemical	Gene	modulate|dobj|START_ENTITY modulate|nsubj|END_ENTITY	Tumor_necrosis_factor_alpha and interleukin-1beta modulate calcium and nitric_oxide signaling in mechanically stimulated osteocytes .
23663262	0	calcium	41,48	UNC-2	66,71	calcium	UNC-2	MESH:D002118	180570(Tax:6239)	Chemical	Gene	channel|compound|START_ENTITY subunits|nsubj|channel subunits|dobj|END_ENTITY	The Caenorhabditis_elegans voltage-gated calcium channel subunits UNC-2 and UNC-36 and the calcium-dependent kinase UNC-43 / CaMKII regulate neuromuscular junction morphology .
9733857	7	calcium	1200,1207	US28	1137,1141	calcium	US28	MESH:D002118	3077536(Tax:10359)	Chemical	Gene	responsible|nmod|START_ENTITY responsible|nsubj|END_ENTITY	In cells infected with HV5 .8 , RANTES did not bind or induce a calcium flux , demonstrating that US28 is responsible for the beta-chemokine binding and induced calcium signaling in HCMV-infected cells .
22774996	0	calcium	31,38	Urocortin_3	0,11	calcium	Urocortin 3	MESH:D002118	114131	Chemical	Gene	elevates|dobj|START_ENTITY elevates|nsubj|END_ENTITY	Urocortin_3 elevates cytosolic calcium in nucleus ambiguus neurons .
7783701	0	calcium	21,28	Uropontin	0,9	calcium	Uropontin	MESH:D002118	6696	Chemical	Gene	formation|compound|START_ENTITY END_ENTITY|nmod|formation	Uropontin in urinary calcium stone formation .
12421360	0	calcium	37,44	Urotensin-II	0,12	calcium	Urotensin-II	MESH:D002118	29180(Tax:10116)	Chemical	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Urotensin-II regulates intracellular calcium in dissociated rat spinal cord neurons .
22223729	0	calcium	106,113	Urotensin-II	0,12	calcium	Urotensin-II	MESH:D002118	29180(Tax:10116)	Chemical	Gene	influx|compound|START_ENTITY operated|dobj|influx signaling|parataxis|operated signaling|nsubj|END_ENTITY	Urotensin-II signaling mechanism in rat coronary artery : role of STIM1 and Orai1-dependent store operated calcium influx in vasoconstriction .
23933581	0	calcium	87,94	Urotensin-II	0,12	calcium	Urotensin-II	MESH:D002118	29180(Tax:10116)	Chemical	Gene	entry|compound|START_ENTITY promotes|nmod|entry promotes|nsubj|END_ENTITY	Urotensin-II promotes vascular smooth muscle cell proliferation through store-operated calcium entry and EGFR transactivation .
12566470	0	calcium	87,94	VDR	20,23	calcium	VDR	MESH:D002118	22337(Tax:10090)	Chemical	Gene	absorption|compound|START_ENTITY regulation|nmod|absorption reveal|dobj|regulation knockout|ccomp|reveal knockout|nsubj|receptor receptor|appos|END_ENTITY	Vitamin_D receptor -LRB- VDR -RRB- knockout mice reveal VDR-independent regulation of intestinal calcium absorption and ECaC2 and calbindin_D9k mRNA .
17204417	0	calcium	14,21	VDR	46,49	calcium	VDR	MESH:D002118	7421	Chemical	Gene	effecter|nsubj|START_ENTITY effecter|nmod|levels levels|compound|END_ENTITY	Extracellular calcium is a direct effecter of VDR levels in proximal tubule epithelial cells that counter-balances effects of PTH on renal Vitamin_D metabolism .
17507731	2	calcium	347,354	VDR	306,309	calcium	VDR	MESH:D002118	7421	Chemical	Gene	metabolism|compound|START_ENTITY involved|nmod|metabolism tissues|acl:relcl|involved suggested|nmod|tissues suggested|nmod|discovery discovery|nmod|receptor receptor|appos|END_ENTITY	More extensive roles for vitamin_D were suggested by the discovery of the vitamin_D receptor -LRB- VDR -RRB- in tissues that are not involved in calcium and phosphate metabolism .
20181667	0	calcium	60,67	VDR	28,31	calcium	VDR	MESH:D002118	24873(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Upregulation of parathyroid VDR expression by extracellular calcium is mediated by ERK1/2-MAPK signaling pathway .
20398755	0	calcium	110,117	VDR	47,50	calcium	VDR	MESH:D002118	7421	Chemical	Gene	intake|compound|START_ENTITY promoter|nmod|intake promoter|nsubj|status status|appos|END_ENTITY	Growth , calcium status and vitamin_D_receptor -LRB- VDR -RRB- promoter genotype in European children with normal or low calcium intake .
21701827	0	calcium	19,26	VDR	79,82	calcium	VDR	MESH:D002118	22337(Tax:10090)	Chemical	Gene	accumulation|nummod|START_ENTITY regulates|dobj|accumulation regulates|advcl|changing changing|dobj|expression expression|compound|END_ENTITY	p38_MAPK regulates calcium signal-mediated lipid accumulation through changing VDR expression in primary preadipocytes of mice .
22137721	0	calcium	59,66	VDR	20,23	calcium	VDR	MESH:D002118	24873(Tax:10116)	Chemical	Gene	proteins|compound|START_ENTITY kidney|nmod|proteins silencing|nmod|kidney silencing|dobj|gene gene|compound|END_ENTITY	Effect of silencing VDR gene in kidney on renal epithelial calcium transporter proteins and urinary calcium excretion in genetic hypercalciuric stone-forming rats .
16054650	0	calcium	30,37	VEGF	0,4	calcium	VEGF	MESH:D002118	7422	Chemical	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	VEGF inhibits PDGF-stimulated calcium signaling independent of phospholipase C and protein_kinase_C .
17551930	0	calcium	46,53	VEGF	92,96	calcium	VEGF	MESH:D002118	7422	Chemical	Gene	dependent|advmod|START_ENTITY signaling|amod|dependent effects|nmod|signaling effects|nmod|expression expression|amod|END_ENTITY	Membrane-initiated effects of progesterone on calcium dependent signaling and activation of VEGF gene expression in retinal glial cells .
18221855	0	calcium	112,119	VEGF	36,40	calcium	VEGF	MESH:D002118	7422	Chemical	Gene	elevation|nmod|START_ENTITY regulates|nmod|elevation regulates|nsubj|Vascular_endothelial_growth_factor Vascular_endothelial_growth_factor|appos|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- signaling regulates hippocampal neurons by elevation of intracellular calcium and activation of calcium/calmodulin protein kinase II and mammalian_target_of_rapamycin .
18419602	0	calcium	114,121	VEGF	137,141	calcium	VEGF	MESH:D002118	7422	Chemical	Gene	independent|compound|START_ENTITY regulated|nmod|independent Overexpression|acl|regulated Overexpression|nmod|END_ENTITY	Overexpression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptors on keratinocytes in psoriasis : regulated by calcium independent of VEGF .
18419602	0	calcium	114,121	VEGF	54,58	calcium	VEGF	MESH:D002118	7422	Chemical	Gene	independent|compound|START_ENTITY regulated|nmod|independent Overexpression|acl|regulated Overexpression|nmod|receptors receptors|appos|END_ENTITY	Overexpression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptors on keratinocytes in psoriasis : regulated by calcium independent of VEGF .
19843006	0	calcium	130,137	VEGF	18,22	calcium	VEGF	MESH:D002118	7422	Chemical	Gene	explants|nmod|START_ENTITY regulates|nmod|explants regulates|nsubj|receptor-1 receptor-1|compound|END_ENTITY	Exogenous soluble VEGF receptor-1 -LRB- sFlt-1 -RRB- regulates Th1/Th2 cytokine production from normal placental explants via intracellular calcium .
10825819	0	calcium	32,39	VIP	0,3	calcium	VIP	MESH:D002118	7432	Chemical	Gene	currents|compound|START_ENTITY inhibits|dobj|currents inhibits|nsubj|END_ENTITY	VIP inhibits high voltage-gated calcium channel currents of hamster submandibular ganglion neurons .
11387265	0	calcium	56,63	Vasopressin	0,11	calcium	Vasopressin	MESH:D002118	551	Chemical	Gene	propagation|compound|START_ENTITY controls|dobj|propagation controls|nsubj|distribution distribution|compound|END_ENTITY	Vasopressin receptor distribution in the liver controls calcium wave propagation and bile flow .
1726121	0	calcium	31,38	Vasopressin	0,11	calcium	Vasopressin	MESH:D002118	551	Chemical	Gene	elevates|dobj|START_ENTITY elevates|nsubj|END_ENTITY	Vasopressin elevates cytosolic calcium in small_cell_lung_cancer cells .
26620256	0	calcium	28,35	Vasopressin	0,11	calcium	Vasopressin	MESH:D002118	551	Chemical	Gene	excretion|compound|START_ENTITY regulates|dobj|excretion regulates|nsubj|END_ENTITY	Vasopressin regulates renal calcium excretion in humans .
2844618	0	calcium	23,30	Vasopressin	0,11	calcium	Vasopressin	MESH:D002118	551	Chemical	Gene	current|compound|START_ENTITY enhances|dobj|current enhances|nsubj|END_ENTITY	Vasopressin enhances a calcium current in human ACTH-secreting pituitary_adenoma cells .
2956892	0	calcium	37,44	Vasopressin	0,11	calcium	Vasopressin	MESH:D002118	396995(Tax:9823)	Chemical	Gene	increases|dobj|START_ENTITY increases|nsubj|END_ENTITY	Vasopressin increases cytosolic free calcium in LLC-PK1 cells through a V1-receptor .
6419286	0	calcium	101,108	Vasopressin	0,11	calcium	Vasopressin	MESH:D002118	551	Chemical	Gene	content|compound|START_ENTITY hepatocyte|dobj|content stimulates|advcl|hepatocyte stimulates|nsubj|END_ENTITY	Vasopressin stimulates thromboxane synthesis in isolated hamster hepatocytes : relation to hepatocyte calcium content .
7758834	0	calcium	51,58	Vasopressin	0,11	calcium	Vasopressin	MESH:D002118	551	Chemical	Gene	transients|compound|START_ENTITY induces|dobj|transients induces|nsubj|END_ENTITY	Vasopressin induces frequency-modulated repetitive calcium transients in single insulin-secreting hit cells .
10320522	0	calcium	51,58	Vitamin_D_receptor	0,18	calcium	Vitamin D receptor	MESH:D002118	7421	Chemical	Gene	absorption|compound|START_ENTITY predicts|dobj|absorption predicts|nsubj|polymorphism polymorphism|compound|END_ENTITY	Vitamin_D_receptor gene Fok1 polymorphism predicts calcium absorption and bone_mineral_density in children .
11385068	0	calcium	55,62	Vitamin_D_receptor	0,18	calcium	Vitamin D receptor	MESH:D002118	22337(Tax:10090)	Chemical	Gene	levels|nmod|START_ENTITY fertile|nsubj|levels fed|ccomp|fertile fed|nsubj|mice mice|amod|END_ENTITY	Vitamin_D_receptor null mutant mice fed high levels of calcium are fertile .
12807755	0	calcium	103,110	Vitamin_D_receptor	0,18	calcium	Vitamin D receptor	MESH:D002118	7421	Chemical	Gene	modification|nmod|START_ENTITY polymorphism|dep|modification polymorphism|amod|END_ENTITY	Vitamin_D_receptor start codon polymorphism and colorectal_cancer risk : effect modification by dietary calcium and fat in Singapore Chinese .
15883634	0	calcium	45,52	Vitamin_D_receptor	0,18	calcium	Vitamin D receptor	MESH:D002118	7421	Chemical	Gene	absorption|compound|START_ENTITY affect|dobj|absorption polymorphisms|xcomp|affect polymorphisms|nsubj|Fok1 Fok1|compound|END_ENTITY	Vitamin_D_receptor Fok1 polymorphisms affect calcium absorption , kinetics , and bone mineralization rates during puberty .
17207992	0	calcium	134,141	Vitamin_D_receptor	35,53	calcium	Vitamin D receptor	MESH:D002118	7421	Chemical	Gene	absorption|compound|START_ENTITY decline|nmod|absorption attenuates|dobj|decline attenuates|nsubj|expression expression|nmod|END_ENTITY	Transgenic expression of the human Vitamin_D_receptor -LRB- hVDR -RRB- in the duodenum of VDR-null mice attenuates the age-dependent decline in calcium absorption .
9137941	0	calcium	101,108	Vitamin_D_receptor	0,18	calcium	Vitamin D receptor	MESH:D002118	7421	Chemical	Gene	intake|compound|START_ENTITY genotypes|nmod|intake genotypes|amod|END_ENTITY	Vitamin_D_receptor genotypes and changes of bone density in physically active German women with high calcium intake .
9438916	0	calcium	64,71	Vitamin_D_receptor	0,18	calcium	Vitamin D receptor	MESH:D002118	7421	Chemical	Gene	excretion|compound|START_ENTITY associated|nmod|excretion associated|nsubjpass|polymorphism polymorphism|amod|END_ENTITY	Vitamin_D_receptor gene polymorphism is associated with urinary calcium excretion but not with bone_mineral_density in postmenopausal women .
9626623	0	calcium	113,120	Vitamin_D_receptor	0,18	calcium	Vitamin D receptor	MESH:D002118	7421	Chemical	Gene	age|appos|START_ENTITY interaction|nmod|age polymorphisms|dep|interaction polymorphisms|amod|END_ENTITY	Vitamin_D_receptor gene start codon polymorphisms -LRB- FokI -RRB- and bone_mineral_density : interaction with age , dietary calcium , and 3 ' - end region polymorphisms .
20404321	0	calcium	40,47	Wnt3a	10,15	calcium	Wnt3a	MESH:D002118	303181(Tax:10116)	Chemical	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	Canonical Wnt3a modulates intracellular calcium and enhances excitatory neurotransmission in hippocampal neurons .
8159177	0	calcium	22,29	X-linked_muscular_dystrophy	67,94	calcium	X-linked muscular dystrophy	MESH:D002118	13405(Tax:10090)	Chemical	Gene	sites|amod|START_ENTITY sites|nmod|END_ENTITY	Anionic phospholipids calcium binding sites in Duchenne and murine X-linked_muscular_dystrophy .
22453917	0	calcium	35,42	a-Synuclein	0,11	calcium	a-Synuclein	MESH:D002118	6622	Chemical	Gene	homeostasis|compound|START_ENTITY controls|dobj|homeostasis controls|nsubj|END_ENTITY	a-Synuclein controls mitochondrial calcium homeostasis by enhancing endoplasmic reticulum-mitochondria interactions .
20853512	0	calcium	50,57	a1G	28,31	calcium	a1G	MESH:D002118	12291(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY subunit|nmod|channel subunit|amod|END_ENTITY	Subcellular distribution of a1G subunit of T-type calcium channel in the mouse dorsal lateral geniculate nucleus .
23864373	0	calcium	14,21	a1T	10,13	calcium	a1T	MESH:D002118	40848(Tax:7227)	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Cav3-type a1T calcium channels mediate transient calcium currents that regulate repetitive firing in Drosophila antennal lobe PNs .
23864373	0	calcium	49,56	a1T	10,13	calcium	a1T	MESH:D002118	40848(Tax:7227)	Chemical	Gene	currents|compound|START_ENTITY mediate|dobj|currents mediate|nsubj|channels channels|amod|END_ENTITY	Cav3-type a1T calcium channels mediate transient calcium currents that regulate repetitive firing in Drosophila antennal lobe PNs .
4221820	0	calcium	41,48	adenosine_triphosphatase	15,39	calcium	adenosine triphosphatase	MESH:D002118	481	Chemical	Gene	activity|dep|START_ENTITY activity|amod|END_ENTITY	Studies on the adenosine_triphosphatase , calcium uptake and relaxing activity of the microsomal granules from skeletal muscle .
2992571	0	calcium	53,60	adenosinetriphosphatase	89,112	calcium	adenosinetriphosphatase	MESH:D002118	481	Chemical	Gene	ion|compound|START_ENTITY ion|amod|END_ENTITY	Exchange rates and numbers of annular lipids for the calcium and magnesium ion dependent adenosinetriphosphatase .
12506319	0	calcium	46,53	adrenomedullin	21,35	calcium	adrenomedullin	MESH:D002118	100733203	Chemical	Gene	currents|compound|START_ENTITY effect|nmod|currents effect|nmod|END_ENTITY	Inhibitory effect of adrenomedullin on L-type calcium currents in guinea-pig ventricular myocytes .
17766482	0	calcium	43,50	adrenomedullin	14,28	calcium	adrenomedullin	MESH:D002118	25026(Tax:10116)	Chemical	Gene	current|compound|START_ENTITY END_ENTITY|nmod|current	The effect of adrenomedullin on the L-type calcium current in myocytes from septic_shock rats : signaling pathway .
21083302	0	calcium	17,24	aid	57,60	calcium	aid	MESH:D002118	57379	Chemical	Gene	Determination|nmod|START_ENTITY Determination|nmod|END_ENTITY	Determination of calcium in synovial fluid samples as an aid to diagnosing osteoarthritis .
16296412	0	calcium	15,22	albumin	49,56	calcium	albumin	MESH:D002118	213	Chemical	Gene	fraction|compound|START_ENTITY ionized|dobj|fraction ionized|nmod|levels levels|compound|END_ENTITY	-LSB- Blood ionized calcium fraction in various serum albumin levels surveyed in non-dialysis patients -RSB- .
17424241	0	calcium	28,35	albumin	45,52	calcium	albumin	MESH:D002118	403550(Tax:9615)	Chemical	Gene	total|dobj|START_ENTITY total|advcl|serum serum|dobj|END_ENTITY	Relationship of serum total calcium to serum albumin in dogs , cats , horses and cattle .
17493	0	calcium	15,22	albumin	39,46	calcium	albumin	MESH:D002118	213	Chemical	Gene	Interaction|nmod|START_ENTITY ions|nsubj|Interaction ions|nmod|END_ENTITY	Interaction of calcium ions with serum albumin in chronic_renal_failure .
1876503	0	calcium	30,37	albumin	11,18	calcium	albumin	MESH:D002118	213	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of albumin on ionized calcium in vitro .
2904583	0	calcium	51,58	albumin	9,16	calcium	albumin	MESH:D002118	213	Chemical	Gene	adjustments|nmod|START_ENTITY adjustments|compound|END_ENTITY	Need for albumin adjustments of urgent total serum calcium .
6435735	0	calcium	34,41	albumin	52,59	calcium	albumin	MESH:D002118	213	Chemical	Gene	concentrations|compound|START_ENTITY concentrations|compound|END_ENTITY	Correlation between serum ionised calcium and serum albumin concentrations in two hospital populations .
8686978	0	calcium	109,116	albumin	28,35	calcium	albumin	MESH:D002118	213	Chemical	Gene	antagonists|compound|START_ENTITY treated|nmod|antagonists Effects|acl|treated Effects|nmod|excretion excretion|compound|END_ENTITY	Effects of sodium intake on albumin excretion in patients with diabetic_nephropathy treated with long-acting calcium antagonists .
3094425	0	calcium	9,16	alpha-MSH	45,54	calcium	alpha-MSH	MESH:D002118	5443	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|secretion secretion|nmod|END_ENTITY	-LSB- Role of calcium in TRH-induced secretion of alpha-MSH in the frog -RSB- .
4043399	0	calcium	33,40	alpha-lactalbumin	65,82	calcium	alpha-lactalbumin	MESH:D002118	281894(Tax:9913)	Chemical	Gene	the|nmod|START_ENTITY the|nmod|END_ENTITY	Thermodynamics of the binding of calcium and strontium to bovine alpha-lactalbumin .
10024348	0	calcium	58,65	alpha1A	50,57	calcium	alpha1A	MESH:D002118	773	Chemical	Gene	subunit|compound|START_ENTITY subunit|amod|END_ENTITY	Functional consequences of mutations in the human alpha1A calcium channel subunit linked to familial_hemiplegic_migraine .
11403683	0	calcium	48,55	alpha1A	11,18	calcium	alpha1A	MESH:D002118	12286(Tax:10090)	Chemical	Gene	mediates|compound|START_ENTITY END_ENTITY|dep|mediates	The Cav2 .1 / alpha1A -LRB- P/Q-type -RRB- voltage-dependent calcium channel mediates inhibitory neurotransmission onto mouse cerebellar Purkinje cells .
12676347	0	calcium	64,71	alpha1A	56,63	calcium	alpha1A	MESH:D002118	773	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Proteolytic cleavage and cellular toxicity of the human alpha1A calcium channel in spinocerebellar_ataxia_type_6 .
12710975	0	calcium	93,100	alpha1A	85,92	calcium	alpha1A	MESH:D002118	12286(Tax:10090)	Chemical	Gene	ion|compound|START_ENTITY ion|amod|END_ENTITY	Fluoro-jade identification of cerebellar granule cell and purkinje cell death in the alpha1A calcium ion channel mutant mouse , leaner .
14744018	0	calcium	78,85	alpha1A	19,26	calcium	alpha1A	MESH:D002118	773	Chemical	Gene	channels|compound|START_ENTITY Purkinje|dobj|channels Purkinje|nsubj|type type|appos|END_ENTITY	Elevated P/Q type -LRB- alpha1A -RRB- and L2 type -LRB- alpha1D -RRB- Purkinje cell voltage-gated calcium channels in the cerebella of seizure prone gerbils .
20735421	0	calcium	77,84	alpha1A	46,53	calcium	alpha1A	MESH:D002118	773	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dep|channels	Pentobarbital inhibition of human recombinant alpha1A P/Q-type voltage-gated calcium channels involves slow , open channel block .
9037084	0	calcium	125,132	alpha1A	141,148	calcium	alpha1A	MESH:D002118	773	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	Molecular determinants of inactivation and G protein modulation in the intracellular loop connecting domains I and II of the calcium channel alpha1A subunit .
9153453	0	calcium	77,84	alpha1A	40,47	calcium	alpha1A	MESH:D002118	773	Chemical	Gene	channel|compound|START_ENTITY subunit|nmod|channel subunit|amod|END_ENTITY	Antibodies to synthetic peptides of the alpha1A subunit of the voltage-gated calcium channel in Lambert-Eaton_myasthenic_syndrome .
9303303	0	calcium	130,137	alpha1A	98,105	calcium	alpha1A	MESH:D002118	773	Chemical	Gene	channel|compound|START_ENTITY subunit|nmod|channel subunit|amod|END_ENTITY	Direct interaction of the calcium sensor protein synaptotagmin_I with a cytoplasmic domain of the alpha1A subunit of the P/Q-type calcium channel .
9303303	0	calcium	26,33	alpha1A	98,105	calcium	alpha1A	MESH:D002118	773	Chemical	Gene	interaction|nmod|START_ENTITY sensor|nsubj|interaction sensor|nmod|domain domain|nmod|subunit subunit|amod|END_ENTITY	Direct interaction of the calcium sensor protein synaptotagmin_I with a cytoplasmic domain of the alpha1A subunit of the P/Q-type calcium channel .
9593683	0	calcium	81,88	alpha1A	49,56	calcium	alpha1A	MESH:D002118	773	Chemical	Gene	channel|compound|START_ENTITY subunit|nmod|channel subunit|amod|END_ENTITY	Interaction of cysteine string proteins with the alpha1A subunit of the P/Q-type calcium channel .
9729301	0	calcium	14,21	alpha1A	30,37	calcium	alpha1A	MESH:D002118	12286(Tax:10090)	Chemical	Gene	Expression|nmod|START_ENTITY channel|nsubj|Expression channel|dobj|mRNA mRNA|amod|END_ENTITY	Expression of calcium channel alpha1A mRNA and protein in the leaner mouse -LRB- tgla/tgla -RRB- cerebellum .
12890773	0	calcium	7,14	alpha1B	23,30	calcium	alpha1B	MESH:D002118	12287(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|nsubj|channel	N-type calcium channel alpha1B subunit -LRB- Cav2 .2 -RRB- knock-out mice display hyperactivity and vigilance state differences .
15175395	0	calcium	27,34	alpha1G	12,19	calcium	alpha1G	MESH:D002118	12291(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Role of the alpha1G T-type calcium channel in spontaneous absence_seizures in mutant mice .
16690884	0	calcium	97,104	alpha1G	82,89	calcium	alpha1G	MESH:D002118	12291(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Bradycardia and slowing of the atrioventricular_conduction in mice lacking CaV3 .1 / alpha1G T-type calcium channels .
17525593	0	calcium	27,34	alpha1G	12,19	calcium	alpha1G	MESH:D002118	12291(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Mutation of alpha1G T-type calcium channels in mice does not change anesthetic requirements for loss of the righting reflex and minimum alveolar concentration but delays the onset of anesthetic induction .
19480703	0	calcium	81,88	alpha1G	66,73	calcium	alpha1G	MESH:D002118	12291(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Expanded alternative splice isoform profiling of the mouse Cav3 .1 / alpha1G T-type calcium channel .
18063658	0	calcium	4,11	alpha2/delta1	20,33	calcium	alpha2/delta1	MESH:D002118	8788	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	The calcium channel alpha2/delta1 subunit is involved in extracellular signalling .
18171920	0	calcium	52,59	alpha2delta	26,37	calcium	alpha2delta	MESH:D002118	36526(Tax:7227)	Chemical	Gene	subunit|compound|START_ENTITY subunit|nummod|END_ENTITY	Mutations in a Drosophila alpha2delta voltage-gated calcium channel subunit reveal a crucial synaptic function .
8380585	0	calcium	30,37	alpha_1-antitrypsin	71,90	calcium	alpha 1-antitrypsin	MESH:D002118	5265	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of endoplasmic reticular calcium in oligosaccharide processing of alpha_1-antitrypsin .
11102459	0	calcium	32,39	alpha_1E	52,60	calcium	alpha 1E	MESH:D002118	12290(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY status|nmod|channels status|nmod|mice mice|amod|END_ENTITY	The status of voltage-dependent calcium channels in alpha_1E knock-out mice .
8071363	0	calcium	63,70	alpha_1E	54,62	calcium	alpha 1E	MESH:D002118	12290(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Structure and functional characterization of neuronal alpha_1E calcium channel subtypes .
9065972	0	calcium	44,51	alpha_1E	60,68	calcium	alpha 1E	MESH:D002118	12290(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY expression|nmod|channel END_ENTITY|nsubj|expression	Isoform expression of the voltage-dependent calcium channel alpha_1E .
7859062	0	calcium	12,19	alpha_MSH	78,87	calcium	alpha MSH	MESH:D002118	5443	Chemical	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	The role of calcium and cAMP in the mechanism of action of two melanocortins : alpha_MSH and the ACTH4-9 analogue Org_2766 .
10799482	0	calcium	98,105	amylin	38,44	calcium	amylin	MESH:D002118	3375	Chemical	Gene	elevations|compound|START_ENTITY intracellular|dobj|elevations intracellular|nsubj|evoke evoke|amod|human human|dep|END_ENTITY	Alzheimer 's beta-amyloid , human islet amylin , and prion_protein fragment evoke intracellular free calcium elevations by a common mechanism in a hypothalamic GnRH neuronal cell line .
2787991	0	calcium	59,66	amylin	32,38	calcium	amylin	MESH:D002118	24476(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY effects|nmod|metabolism effects|nmod|END_ENTITY	In vivo and in vitro effects of amylin and amylin-amide on calcium metabolism in the rat and rabbit .
7820778	0	calcium	68,75	amylin	27,33	calcium	amylin	MESH:D002118	403909(Tax:9615)	Chemical	Gene	excretion|nmod|START_ENTITY increases|dobj|excretion increases|nsubj|polypeptide polypeptide|appos|END_ENTITY	Islet amyloid polypeptide -LRB- amylin -RRB- increases the renal excretion of calcium in the conscious dog .
17870249	0	calcium	61,68	androgen_receptor	18,35	calcium	androgen receptor	MESH:D002118	24208(Tax:10116)	Chemical	Gene	response|compound|START_ENTITY alters|dobj|response alters|nsubj|Activation Activation|nmod|END_ENTITY	Activation of the androgen_receptor alters the intracellular calcium response to glutamate in primary hippocampal neurons and modulates sarco/endoplasmic reticulum calcium ATPase 2 transcription .
23748361	0	calcium	100,107	androgen_receptor	16,33	calcium	androgen receptor	MESH:D002118	11835(Tax:10090)	Chemical	Gene	dysregulation|compound|START_ENTITY modulates|nmod|dysregulation modulates|nsubj|Ablation Ablation|nmod|gene gene|compound|END_ENTITY	Ablation of the androgen_receptor gene modulates atrial electrophysiology and arrhythmogenesis with calcium protein dysregulation .
2610688	0	calcium	67,74	angiotensin-II	30,44	calcium	angiotensin-II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Biphasic increasing effect of angiotensin-II on intracellular free calcium in isolated rat early proximal tubule .
7690361	0	calcium	25,32	angiotensin-II	84,98	calcium	angiotensin-II	MESH:D002118	183	Chemical	Gene	role|nmod|START_ENTITY release|nsubj|role release|nmod|END_ENTITY	A role for extracellular calcium in the regulation of placental_lactogen release by angiotensin-II and dopamine in human term trophoblastic cells .
8033823	0	calcium	25,32	angiotensin-II	80,94	calcium	angiotensin-II	MESH:D002118	183	Chemical	Gene	influx|compound|START_ENTITY influx|nmod|activation activation|nmod|steroidogenesis steroidogenesis|nmod|END_ENTITY	Role of the capacitative calcium influx in the activation of steroidogenesis by angiotensin-II in adrenal glomerulosa cells .
10453759	0	calcium	15,22	angiotensin_II	35,49	calcium	angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	Cytosolic free calcium response to angiotensin_II in aortic VSMC isolated from male and female SHR .
11134246	0	calcium	56,63	angiotensin_II	91,105	calcium	angiotensin II	MESH:D002118	183	Chemical	Gene	mobilization|compound|START_ENTITY mobilization|acl|stimulated stimulated|nmod|END_ENTITY	Iloprost inhibits inositol-1 ,4,5 - trisphosphate-mediated calcium mobilization stimulated by angiotensin_II in cultured preglomerular vascular smooth muscle cells .
11433227	0	calcium	92,99	angiotensin_II	34,48	calcium	angiotensin II	MESH:D002118	183	Chemical	Gene	regulation|nmod|START_ENTITY participate|nmod|regulation participate|nsubj|receptors receptors|nmod|END_ENTITY	Both subtype 1 and 2 receptors of angiotensin_II participate in regulation of intracellular calcium in glomerular epithelial cells .
11483290	0	calcium	94,101	angiotensin_II	35,49	calcium	angiotensin II	MESH:D002118	183	Chemical	Gene	release|compound|START_ENTITY depends|nmod|release depends|nsubj|vasoconstriction vasoconstriction|nmod|END_ENTITY	Postglomerular vasoconstriction to angiotensin_II and norepinephrine depends on intracellular calcium release .
11691863	0	calcium	33,40	angiotensin_II	53,67	calcium	angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|nmod|END_ENTITY	Selective potentiation of N-type calcium channels by angiotensin_II in rat subfornical organ neurones .
12127057	0	calcium	51,58	angiotensin_II	4,18	calcium	angiotensin II	MESH:D002118	183	Chemical	Gene	mobilization|compound|START_ENTITY mediates|dobj|mobilization mediates|nsubj|receptor receptor|compound|END_ENTITY	AT1 angiotensin_II receptor mediates intracellular calcium mobilization in normal and cancerous breast cells in primary culture .
12409960	0	calcium	36,43	angiotensin_II	94,108	calcium	angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	difference|nmod|START_ENTITY difference|dep|effect effect|nmod|END_ENTITY	Gender-dependent difference in cell calcium handling in VSMC isolated from SHR : the effect of angiotensin_II .
12511530	0	calcium	75,82	angiotensin_II	14,28	calcium	angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|responses responses|amod|END_ENTITY	Modulation of angiotensin_II responses in sympathetic neurons by cytosolic calcium .
12754110	0	calcium	69,76	angiotensin_II	51,65	calcium	angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	mobilization|compound|START_ENTITY END_ENTITY|nmod|mobilization	Interaction of dimercaptosuccinic_acid -LRB- DMSA -RRB- with angiotensin_II on calcium mobilization in vascular smooth muscle cells .
12951362	0	calcium	121,128	angiotensin_II	48,62	calcium	angiotensin II	MESH:D002118	183	Chemical	Gene	channels|compound|START_ENTITY activating|dobj|channels participates|advcl|activating participates|nmod|vasoconstriction vasoconstriction|amod|END_ENTITY	12-Hydroxyeicosatetraenoic_acid participates in angiotensin_II afferent arteriolar vasoconstriction by activating L-type calcium channels .
1312551	0	calcium	60,67	angiotensin_II	14,28	calcium	angiotensin II	MESH:D002118	183	Chemical	Gene	concentration|compound|START_ENTITY intracellular|dobj|concentration intracellular|nsubj|effect effect|nmod|END_ENTITY	The effect of angiotensin_II on platelet intracellular free calcium concentration in human pregnancy .
1318127	0	calcium	117,124	angiotensin_II	14,28	calcium	angiotensin II	MESH:D002118	183	Chemical	Gene	blockers|compound|START_ENTITY vascular|nmod|blockers vascular|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of angiotensin_II and platelet-derived growth factor-induced vascular smooth muscle cell proliferation by calcium entry blockers .
14660489	0	calcium	19,26	angiotensin_II	49,63	calcium	angiotensin II	MESH:D002118	183	Chemical	Gene	transients|compound|START_ENTITY induced|nsubj|transients induced|nmod|END_ENTITY	Chloride-dependent calcium transients induced by angiotensin_II in vascular smooth muscle cells .
1508324	0	calcium	16,23	angiotensin_II	110,124	calcium	angiotensin II	MESH:D002118	11847(Tax:10090)	Chemical	Gene	Mobilization|nmod|START_ENTITY store|nsubj|Mobilization store|nmod|mechanism mechanism|acl|underlying underlying|dobj|effect effect|nmod|END_ENTITY	Mobilization of calcium from intracellular store as a possible mechanism underlying the anti-opioid effect of angiotensin_II .
15085058	0	calcium	17,24	angiotensin_II	49,63	calcium	angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	mobilization|compound|START_ENTITY mobilization|acl|induced induced|nmod|END_ENTITY	Etomidate alters calcium mobilization induced by angiotensin_II in rat aortic smooth muscle cells .
1520073	0	calcium	16,23	angiotensin_II	62,76	calcium	angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY intake|nsubj|Effect intake|nmod|END_ENTITY	Effect of a low calcium intake on the vascular sensitivity to angiotensin_II in normotensive pregnant rats .
15289467	0	calcium	66,73	angiotensin_II	32,46	calcium	angiotensin II	MESH:D002118	183	Chemical	Gene	current|compound|START_ENTITY enhance|dobj|current enhance|nsubj|END_ENTITY	Intracellular and extracellular angiotensin_II enhance the L-type calcium current in the failing heart .
15604129	0	calcium	69,76	angiotensin_II	45,59	calcium	angiotensin II	MESH:D002118	183	Chemical	Gene	transport|compound|START_ENTITY role|nmod|transport Reversal|dep|role Reversal|nmod|preconditioning preconditioning|nmod|END_ENTITY	Reversal of hyperglycemic preconditioning by angiotensin_II : role of calcium transport .
16115036	0	calcium	40,47	angiotensin_II	61,75	calcium	angiotensin II	MESH:D002118	183	Chemical	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Reactive oxygen species as mediators of calcium signaling by angiotensin_II : implications in vascular physiology and pathophysiology .
16123104	0	calcium	95,102	angiotensin_II	156,170	calcium	angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY facilitation|nmod|channels tyrosine|nmod|facilitation tyrosine|nmod|END_ENTITY	Involvement of Src tyrosine kinase and mitogen-activated protein kinase in the facilitation of calcium channels in rat nucleus of the tractus solitarius by angiotensin_II .
16210376	0	calcium	124,131	angiotensin_II	159,173	calcium	angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	responses|compound|START_ENTITY regulate|dobj|responses regulate|nmod|III III|compound|END_ENTITY	Tyrosine kinase and mitogen-activated protein kinase/extracellularly regulated kinase differentially regulate intracellular calcium concentration responses to angiotensin_II / III and bradykinin in rat cortical thick ascending limb .
16685212	0	calcium	99,106	angiotensin_II	158,172	calcium	angiotensin II	MESH:D002118	183	Chemical	Gene	mobilization|compound|START_ENTITY mobilization|acl|induced induced|nmod|END_ENTITY	Reduced expression of regulator_of_G-protein_signaling_2 -LRB- RGS2 -RRB- in hypertensive patients increases calcium mobilization and ERK1/2 phosphorylation induced by angiotensin_II .
1691390	0	calcium	20,27	angiotensin_II	48,62	calcium	angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY Effect|nmod|channel blockers|nsubj|Effect blockers|nmod|biosynthesis biosynthesis|amod|END_ENTITY	Effect of different calcium channel blockers on angiotensin_II - and vasopressin-induced prostacyclin biosynthesis in vascular smooth muscle cells .
17965735	0	calcium	115,122	angiotensin_II	11,25	calcium	angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	blockers|compound|START_ENTITY Effects|nmod|blockers Effects|nmod|blockade blockade|amod|END_ENTITY	Effects of angiotensin_II blockade on inflammation-induced alterations of pharmacokinetics and pharmacodynamics of calcium channel blockers .
1852119	0	calcium	8,15	angiotensin_II	36,50	calcium	angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Dietary calcium modulates renal BBM angiotensin_II binding and Na -LRB- + -RRB- - H + antiporter activity in SHR .
18585409	0	calcium	93,100	angiotensin_II	64,78	calcium	angiotensin II	MESH:D002118	183	Chemical	Gene	current|compound|START_ENTITY END_ENTITY|nmod|current	Eplerenone inhibits the intracrine and extracellular actions of angiotensin_II on the inward calcium current in the failing heart .
21340439	0	calcium	65,72	angiotensin_II	84,98	calcium	angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY response|nmod|channel enhances|dobj|response enhances|nmod|END_ENTITY	-LSB- Short-term simulated weightlessness enhances response of L-type calcium channel to angiotensin_II in cerebral vascular smooth muscle cells in rats -RSB- .
21525790	0	calcium	7,14	angiotensin_II	43,57	calcium	angiotensin II	MESH:D002118	183	Chemical	Gene	subunit|compound|START_ENTITY modulates|nsubj|subunit modulates|dobj|responses responses|amod|END_ENTITY	L-type calcium channel b subunit modulates angiotensin_II responses in cardiomyocytes .
222757	0	calcium	12,19	angiotensin_II	56,70	calcium	angiotensin II	MESH:D002118	183	Chemical	Gene	ion|compound|START_ENTITY role|nmod|ion role|nmod|END_ENTITY	The role of calcium ion as a mediator of the effects of angiotensin_II , catecholamines , and vasopressin on the phosphorylation and activity of enzymes in isolated hepatocytes .
230977	0	calcium	12,19	angiotensin_II	64,78	calcium	angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of calcium and cyclic_AMP in the contractile action of angiotensin_II upon rat descending colon .
2373048	0	calcium	10,17	angiotensin_II	128,142	calcium	angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	START_ENTITY|dep|comparison comparison|nmod|END_ENTITY	Cytosolic calcium and aldosterone response patterns of rat adrenal glomerulosa cells stimulated by vasopressin : comparison with angiotensin_II .
2410410	0	calcium	57,64	angiotensin_II	19,33	calcium	angiotensin II	MESH:D002118	183	Chemical	Gene	influx|compound|START_ENTITY K|dobj|influx K|nsubj|Characteristics Characteristics|nmod|END_ENTITY	Characteristics of angiotensin_II - , K + - and ACTH-induced calcium influx in adrenal glomerulosa cells .
2410410	1	calcium	163,170	angiotensin_II	116,130	calcium	angiotensin II	MESH:D002118	183	Chemical	Gene	channel|compound|START_ENTITY open|dobj|channel open|nsubj|Evidence Evidence|nmod|END_ENTITY	Evidence that angiotensin_II , K + , and ACTH may open a common calcium channel .
2416549	0	calcium	35,42	angiotensin_II	105,119	calcium	angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY Participation|nmod|channels function|nsubj|Participation function|nmod|END_ENTITY	Participation of voltage-dependent calcium channels in the regulation of adrenal glomerulosa function by angiotensin_II and potassium .
2417828	0	calcium	95,102	angiotensin_II	25,39	calcium	angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	BAY_K_8644|compound|START_ENTITY secretion|nmod|BAY_K_8644 secretion|nsubj|enhancement enhancement|nmod|aldosterone aldosterone|amod|END_ENTITY	Selective enhancement of angiotensin_II - and potassium-stimulated aldosterone secretion by the calcium channel agonist BAY_K_8644 .
2461852	0	calcium	80,87	angiotensin_II	101,115	calcium	angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	responses|compound|START_ENTITY responses|nmod|END_ENTITY	Activation of dihydropyridine-sensitive calcium channels and biphasic cytosolic calcium responses by angiotensin_II in rat adrenal glomerulosa cells .
24680379	0	calcium	86,93	angiotensin_II	21,35	calcium	angiotensin II	MESH:D002118	183	Chemical	Gene	influx|compound|START_ENTITY mediating|dobj|influx induced|advcl|mediating END_ENTITY|acl|induced	TRPM7 is involved in angiotensin_II induced cardiac fibrosis development by mediating calcium and magnesium influx .
2478823	0	calcium	78,85	angiotensin_II	29,43	calcium	angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY Comparison|nmod|concentration Comparison|nmod|effects effects|nmod|END_ENTITY	Comparison of the effects of angiotensin_II and vasopressin on cytosolic free calcium concentration , protein_kinase_C activity , and prostacyclin production in cultured rat aortic and mesenteric smooth muscle cells .
2526631	0	calcium	26,33	angiotensin_II	90,104	calcium	angiotensin II	MESH:D002118	183	Chemical	Gene	mobilization|compound|START_ENTITY valinomycin|nmod|mobilization Effects|nmod|valinomycin induced|nsubj|Effects induced|nmod|END_ENTITY	Effects of valinomycin on calcium mobilization in vascular smooth muscle cells induced by angiotensin_II .
2550243	0	calcium	6,13	angiotensin_II	91,105	calcium	angiotensin II	MESH:D002118	183	Chemical	Gene	blockade|compound|START_ENTITY inhibits|nsubj|blockade inhibits|nmod|END_ENTITY	Acute calcium entry blockade inhibits the blood pressure but not the hormonal responses to angiotensin_II .
2650707	0	calcium	29,36	angiotensin_II	56,70	calcium	angiotensin II	MESH:D002118	183	Chemical	Gene	free|dobj|START_ENTITY free|nmod|END_ENTITY	Increased intracellular free calcium and sensitivity to angiotensin_II in platelets of preeclamptic women .
2762844	0	calcium	69,76	angiotensin_II	25,39	calcium	angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	-RSB-|compound|START_ENTITY effects|nmod|-RSB- effects|nmod|END_ENTITY	-LSB- Antagonistic effects of angiotensin_II and morphine on synaptosomal calcium uptake -RSB- .
2912686	0	calcium	30,37	angiotensin_II	89,103	calcium	angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	Perturbation|nmod|START_ENTITY ion|nsubj|Perturbation ion|nmod|END_ENTITY	Perturbation of intracellular calcium ion concentration in single rat granulosa cells by angiotensin_II .
2985562	0	calcium	22,29	angiotensin_II	73,87	calcium	angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	START_ENTITY|acl|induced induced|nmod|vasopressin vasopressin|compound|END_ENTITY	Increase in cytosolic calcium and phosphoinositide metabolism induced by angiotensin_II and -LSB- Arg -RSB- vasopressin in vascular smooth muscle cells .
3015562	0	calcium	124,131	angiotensin_II	22,36	calcium	angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	monophosphate|nmod|START_ENTITY Comparative|dep|monophosphate Comparative|dobj|effect effect|nmod|END_ENTITY	Comparative effect of angiotensin_II , potassium , adrenocorticotropin , and cyclic_adenosine_3 ' ,5 ' - monophosphate on cytosolic calcium in rat adrenal cells .
3098111	0	calcium	47,54	angiotensin_II	17,31	calcium	angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	products|compound|START_ENTITY modulation|nmod|products effects|dep|modulation effects|nmod|END_ENTITY	Renal effects of angiotensin_II : modulation by calcium and cyclooxygenase products .
3100336	0	calcium	91,98	angiotensin_II	29,43	calcium	angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	rise|nmod|START_ENTITY rise|amod|END_ENTITY	Pertussis toxin inhibits the angiotensin_II and serotonin-induced rise of free cytoplasmic calcium in cultured smooth muscle cells from rat aorta .
3104319	0	calcium	50,57	angiotensin_II	79,93	calcium	angiotensin II	MESH:D002118	183	Chemical	Gene	pool|nmod|START_ENTITY restoration|nmod|pool restoration|nmod|action action|amod|END_ENTITY	Time-dependent restoration of the trigger pool of calcium after termination of angiotensin_II action in adrenal glomerulosa cells .
3241276	0	calcium	8,15	angiotensin_II	51,65	calcium	angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY induced|nsubj|Role induced|nmod|END_ENTITY	Role of calcium in the vasoconstriction induced by angiotensin_II .
3818628	0	calcium	29,36	angiotensin_II	49,63	calcium	angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	response|compound|START_ENTITY resolved|dobj|response resolved|nmod|END_ENTITY	Spatially resolved cytosolic calcium response to angiotensin_II and potassium in rat glomerulosa cells measured by digital imaging techniques .
4061524	0	calcium	10,17	angiotensin_II	65,79	calcium	angiotensin II	MESH:D002118	183	Chemical	Gene	Effect|nmod|START_ENTITY supplementation|nsubj|Effect supplementation|nmod|END_ENTITY	Effect of calcium supplementation on the vascular sensitivity to angiotensin_II in pregnant women .
7094540	0	calcium	86,93	angiotensin_II	41,55	calcium	angiotensin II	MESH:D002118	183	Chemical	Gene	metabolism|compound|START_ENTITY variations|nmod|metabolism END_ENTITY|nmod|variations	Studies on aldosterone responsiveness to angiotensin_II during clinical variations in calcium metabolism in normal man .
7511744	0	calcium	114,121	angiotensin_II	14,28	calcium	angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY increases|nmod|concentration Effects|nmod|increases Effects|nmod|receptor receptor|amod|END_ENTITY	Effects of an angiotensin_II receptor antagonist , CV-11974 , on angiotensin_II-induced increases in cytosolic free calcium concentration , hyperplasia , and hypertrophy of cultured vascular smooth muscle cells .
7731059	0	calcium	28,35	angiotensin_II	10,24	calcium	angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	phenomena|compound|START_ENTITY END_ENTITY|nmod|phenomena	Effect of angiotensin_II on calcium release phenomena in normal and hypertrophied single cardiac myocytes .
7755454	0	calcium	52,59	angiotensin_II	12,26	calcium	angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	releases|compound|START_ENTITY END_ENTITY|nmod|releases	-LSB- Effects of angiotensin_II on spontaneous cytosolic calcium releases in ventricular myocytes of adult normal and hypertensive rats -RSB- .
7771808	0	calcium	8,15	angiotensin_II	77,91	calcium	angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|activation activation|nmod|cells cells|amod|phospholipase_D phospholipase_D|nmod|END_ENTITY	Role of calcium and protein_kinase_C in the activation of phospholipase_D by angiotensin_II in vascular smooth muscle cells .
7895673	0	calcium	43,50	angiotensin_II	89,103	calcium	angiotensin II	MESH:D002118	183	Chemical	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Dissociation of increases in intracellular calcium and aldosterone production induced by angiotensin_II -LRB- AII -RRB- : evidence for regulation by distinct AII receptor subtypes or isomorphs .
7963491	0	calcium	95,102	angiotensin_II	116,130	calcium	angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	responses|compound|START_ENTITY display|dobj|responses display|nmod|END_ENTITY	Mesenteric vascular smooth muscle cells from spontaneously hypertensive rats display increased calcium responses to angiotensin_II but not to endothelin-1 .
7965106	0	calcium	34,41	angiotensin_II	16,30	calcium	angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	currents|compound|START_ENTITY END_ENTITY|nmod|currents	Dual effects of angiotensin_II on calcium currents in neonatal rat nodose neurons .
8584237	0	calcium	161,168	angiotensin_II	18,32	calcium	angiotensin II	MESH:D002118	183	Chemical	Gene	transfected|nmod|START_ENTITY transfected|nsubj|effect effect|nmod|receptor receptor|amod|END_ENTITY	The effect of the angiotensin_II -LRB- AT1A -RRB- receptor stably transfected into human neuroblastoma SH-SY5Y cells on noradrenaline release and changes in intracellular calcium .
8621201	0	calcium	10,17	angiotensin_II	123,137	calcium	angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	changes|compound|START_ENTITY mediated|nsubjpass|changes mediated|nmod|receptors receptors|amod|END_ENTITY	Cytosolic calcium changes induced by angiotensin_II in neonatal rat atrial and ventricular cardiomyocytes are mediated via angiotensin_II subtype 1 receptors .
8621201	0	calcium	10,17	angiotensin_II	37,51	calcium	angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	changes|compound|START_ENTITY changes|acl|induced induced|nmod|END_ENTITY	Cytosolic calcium changes induced by angiotensin_II in neonatal rat atrial and ventricular cardiomyocytes are mediated via angiotensin_II subtype 1 receptors .
8651927	0	calcium	14,21	angiotensin_II	32,46	calcium	angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	Activation|nmod|START_ENTITY sparks|nsubj|Activation sparks|nmod|END_ENTITY	Activation of calcium sparks by angiotensin_II in vascular myocytes .
8762048	0	calcium	26,33	angiotensin_II	81,95	calcium	angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	genes|compound|START_ENTITY abundance|nmod|genes induced|nsubj|abundance induced|nmod|END_ENTITY	Altered mRNA abundance of calcium transport genes in cardiac myocytes induced by angiotensin_II .
8781749	0	calcium	76,83	angiotensin_II	8,22	calcium	angiotensin II	MESH:D002118	183	Chemical	Gene	blocker|compound|START_ENTITY caused|nmod|blocker caused|nsubj|Role Role|nmod|END_ENTITY	Role of angiotensin_II in reflex tachycardia during hypotension caused by a calcium channel blocker .
8995721	0	calcium	24,31	angiotensin_II	43,57	calcium	angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	Alteration|nmod|START_ENTITY induced|nsubj|Alteration induced|nmod|END_ENTITY	Alteration of cytosolic calcium induced by angiotensin_II and norepinephrine in mesangial cells from diabetic rats .
9080454	0	calcium	23,30	angiotensin_II	54,68	calcium	angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	Modulation|nmod|START_ENTITY homeostasis|nsubj|Modulation homeostasis|nmod|END_ENTITY	Modulation of cerebral calcium homeostasis in rats by angiotensin_II in vivo .
9280210	0	calcium	10,17	angiotensin_II	113,127	calcium	angiotensin II	MESH:D002118	183	Chemical	Gene	changes|compound|START_ENTITY mediated|nsubjpass|changes mediated|nmod|receptors receptors|amod|END_ENTITY	Cytosolic calcium changes induced by angiotensin_II in human peripheral blood mononuclear cells are mediated via angiotensin_II subtype 1 receptors .
9280210	0	calcium	10,17	angiotensin_II	37,51	calcium	angiotensin II	MESH:D002118	183	Chemical	Gene	changes|compound|START_ENTITY changes|acl|induced induced|nmod|END_ENTITY	Cytosolic calcium changes induced by angiotensin_II in human peripheral blood mononuclear cells are mediated via angiotensin_II subtype 1 receptors .
9344225	0	calcium	38,45	angiotensin_II	63,77	calcium	angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY concentration|nmod|END_ENTITY	High responsiveness of cytosolic free calcium concentration to angiotensin_II in cultured pulmonary arterial myocytes from pulmonary hypertensive rats .
9797194	0	calcium	43,50	angiotensin_II	77,91	calcium	angiotensin II	MESH:D002118	183	Chemical	Gene	START_ENTITY|nmod|fibroblasts fibroblasts|nmod|END_ENTITY	Modulatory effect of insulin on release of calcium from human fibroblasts by angiotensin_II .
9856960	0	calcium	50,57	angiotensin_II	14,28	calcium	angiotensin II	MESH:D002118	24179(Tax:10116)	Chemical	Gene	current|compound|START_ENTITY regulates|dobj|current regulates|nsubj|END_ENTITY	Intracellular angiotensin_II regulates the inward calcium current in cardiac myocytes .
1832677	0	calcium	204,211	annexin_II	21,31	calcium	annexin II	MESH:D002118	302	Chemical	Gene	concentrations|compound|START_ENTITY micromolar|dobj|concentrations secrete|advcl|micromolar Permeabilized|acl:relcl|secrete requires|dobj|Permeabilized requires|nsubj|participation participation|nmod|END_ENTITY	The participation of annexin_II -LRB- calpactin I -RRB- in calcium-evoked exocytosis requires protein kinase C. Permeabilized adrenal chromaffin cells secrete catecholamines by exocytosis in response to micromolar calcium concentrations .
2148156	0	calcium	4,11	annexin_V	35,44	calcium	annexin V	MESH:D002118	308	Chemical	Gene	binding|nsubj|START_ENTITY binding|nmod|END_ENTITY	The calcium binding sites in human annexin_V by crystal structure analysis at 2.0 A resolution .
8889153	0	calcium	14,21	annexin_V	42,51	calcium	annexin V	MESH:D002118	308	Chemical	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Similarity in calcium channel activity of annexin_V and matrix vesicles in planar lipid bilayers .
7516610	0	calcium	64,71	aprotinin	11,20	calcium	aprotinin	MESH:D002118	100158011(Tax:9823)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of aprotinin in platelet_aggregation and cytosolic free calcium in swine platelets .
1688546	0	calcium	14,21	atrial_natriuretic_factor	59,84	calcium	atrial natriuretic factor	MESH:D002118	24602(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|gene gene|nmod|END_ENTITY	Extracellular calcium regulates expression of the gene for atrial_natriuretic_factor .
1714900	0	calcium	102,109	atrial_natriuretic_factor	36,61	calcium	atrial natriuretic factor	MESH:D002118	4878	Chemical	Gene	influx|compound|START_ENTITY requires|dobj|influx requires|nsubj|stimulation stimulation|nmod|expression expression|compound|END_ENTITY	The alpha-adrenergic stimulation of atrial_natriuretic_factor expression in cardiac myocytes requires calcium influx , protein kinase C , and calmodulin-regulated pathways .
2473074	0	calcium	95,102	atrial_natriuretic_factor	11,36	calcium	atrial natriuretic factor	MESH:D002118	24602(Tax:10116)	Chemical	Gene	contraction|compound|START_ENTITY Effects|nmod|contraction Effects|nmod|END_ENTITY	Effects of atrial_natriuretic_factor -LRB- ANF -RRB- on phenylephrine-triggered intra - and extracellular calcium dependent contraction in rat aorta .
2977169	0	calcium	11,18	atrial_natriuretic_factor	49,74	calcium	atrial natriuretic factor	MESH:D002118	24602(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|release release|nmod|END_ENTITY	Effects of calcium and ouabain on the release of atrial_natriuretic_factor .
7511588	0	calcium	27,34	atrial_natriuretic_factor	76,101	calcium	atrial natriuretic factor	MESH:D002118	24602(Tax:10116)	Chemical	Gene	Involvement|nmod|START_ENTITY kinases|nsubj|Involvement kinases|nmod|regulation regulation|nmod|secretion secretion|compound|END_ENTITY	Involvement of cytoplasmic calcium and protein kinases in the regulation of atrial_natriuretic_factor secretion by contraction rate and endothelin .
1830445	0	calcium	11,18	atrial_natriuretic_peptide	69,95	calcium	atrial natriuretic peptide	MESH:D002118	24602(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY supplementation|nsubj|Effects supplementation|nmod|END_ENTITY	Effects of calcium supplementation and deoxycorticosterone on plasma atrial_natriuretic_peptide and electrolyte excretion in spontaneously hypertensive rats .
2436485	0	calcium	8,15	atrial_natriuretic_peptide	30,56	calcium	atrial natriuretic peptide	MESH:D002118	24602(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|effects effects|nmod|END_ENTITY	Role of calcium in effects of atrial_natriuretic_peptide on aldosterone production in adrenal glomerulosa cells .
2528639	0	calcium	14,21	atrial_natriuretic_peptide	37,63	calcium	atrial natriuretic peptide	MESH:D002118	24602(Tax:10116)	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|nmod|END_ENTITY	The effect of calcium antagonists on atrial_natriuretic_peptide -LRB- ANP -RRB- release from the rat heart during rapid cardiac pacing .
16814688	0	calcium	63,70	beta-endorphin	21,35	calcium	beta-endorphin	MESH:D002118	5443	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	The effects of pH on beta-endorphin and morphine inhibition of calcium transients in dorsal root ganglion neurons .
2428932	0	calcium	158,165	beta-endorphin	84,98	calcium	beta-endorphin	MESH:D002118	18976(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY blockade|nmod|channels inhibits|nmod|blockade inhibits|dobj|release release|amod|END_ENTITY	Evidence that the peripheral-type benzodiazepine receptor ligand Ro_5-4864 inhibits beta-endorphin release from AtT-20 cells by blockade of voltage-dependent calcium channels .
14500989	0	calcium	90,97	beta1	39,44	calcium	beta1	MESH:D002118	15129(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|nmod|channel	Structures of the murine genes for the beta1 - and beta4-subunits of the voltage-dependent calcium channel .
14674701	0	calcium	95,102	beta2	56,61	calcium	beta2	MESH:D002118	15130(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY subunit|nmod|channel subunit|amod|END_ENTITY	Genetic characterization of a new splice variant of the beta2 subunit of the voltage-dependent calcium channel .
11206725	0	calcium	155,162	beta3	116,121	calcium	beta3	MESH:D002118	12297(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY subunit|nmod|channel subunit|amod|END_ENTITY	Conserved smooth muscle contractility and blood pressure increase in response to high-salt diet in mice lacking the beta3 subunit of the voltage-dependent calcium channel .
10407181	0	calcium	154,161	beta3_and_decreased_beta4	128,153	calcium	beta3 and decreased beta4	MESH:D002118	12297(Tax:10090)	Chemical	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Decreased -LRB- 45 -RRB- Ca -LRB- 2 -RRB- -LRB- + -RRB- uptake in P/Q-type calcium channels in homozygous lethargic -LRB- Cacnb4lh -RRB- mice is associated with increased beta3_and_decreased_beta4 calcium channel subunit mRNA expression .
10407181	0	calcium	42,49	beta3_and_decreased_beta4	128,153	calcium	beta3 and decreased beta4	MESH:D002118	12297(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY uptake|nmod|channels associated|nsubjpass|uptake associated|nmod|expression expression|amod|END_ENTITY	Decreased -LRB- 45 -RRB- Ca -LRB- 2 -RRB- -LRB- + -RRB- uptake in P/Q-type calcium channels in homozygous lethargic -LRB- Cacnb4lh -RRB- mice is associated with increased beta3_and_decreased_beta4 calcium channel subunit mRNA expression .
16716259	0	calcium	23,30	bone_morphogenetic_protein_2	55,83	calcium	bone morphogenetic protein 2	MESH:D002118	12156(Tax:10090)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|nmod|END_ENTITY	Elevated extracellular calcium stimulates secretion of bone_morphogenetic_protein_2 by a macrophage cell line .
11125421	0	calcium	37,44	bradykinin	11,21	calcium	bradykinin	MESH:D002118	3827	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of bradykinin on cytoplasmic calcium and motility in murine bladder_tumor cells .
1282721	0	calcium	43,50	bradykinin	10,20	calcium	bradykinin	MESH:D002118	3827	Chemical	Gene	activity|compound|START_ENTITY Effect|nmod|activity Effect|nmod|END_ENTITY	Effect of bradykinin on the cytosolic free calcium activity and phosphoinositol turnover in human glomerular epithelial cells .
1651669	0	calcium	39,46	bradykinin	11,21	calcium	bradykinin	MESH:D002118	3827	Chemical	Gene	regulation|compound|START_ENTITY Effects|nmod|regulation Effects|nmod|END_ENTITY	Effects of bradykinin on intracellular calcium regulation in human ciliated airway epithelium .
1663586	0	calcium	66,73	bradykinin	20,30	calcium	bradykinin	MESH:D002118	3827	Chemical	Gene	increase|nmod|START_ENTITY responsible|nmod|increase responsible|nsubj|END_ENTITY	Endothelium-derived bradykinin is responsible for the increase in calcium produced by angiotensin-converting_enzyme inhibitors in human endothelial cells .
19190685	0	calcium	44,51	bradykinin	8,18	calcium	bradykinin	MESH:D002118	3827	Chemical	Gene	release|compound|START_ENTITY triggers|dobj|release triggers|nsubj|END_ENTITY	Initial bradykinin triggers calcium-induced calcium release in C6_glioma cells and its significance .
2001422	0	calcium	60,67	bradykinin	78,88	calcium	bradykinin	MESH:D002118	3827	Chemical	Gene	START_ENTITY|nmod|stimulation stimulation|compound|END_ENTITY	Interactions between inositol_phosphates and cytosolic free calcium following bradykinin stimulation in cultured human skin fibroblasts .
22304761	0	calcium	70,77	bradykinin	8,18	calcium	bradykinin	MESH:D002118	3827	Chemical	Gene	modulation|compound|START_ENTITY alters|dobj|modulation alters|nsubj|treatment treatment|compound|END_ENTITY	Chronic bradykinin treatment alters 1a,25-dihydroxyvitamin _ D3-induced calcium current modulation in pre-osteoblasts .
5780001	0	calcium	79,86	bradykinin	24,34	calcium	bradykinin	MESH:D002118	3827	Chemical	Gene	action|nmod|START_ENTITY action|nmod|END_ENTITY	The mitogenic action of bradykinin on thymic lymphocytes and its dependence on calcium .
7515323	0	calcium	25,32	bradykinin	67,77	calcium	bradykinin	MESH:D002118	3827	Chemical	Gene	Enhancement|nmod|START_ENTITY Enhancement|nmod|END_ENTITY	Enhancement of cytosolic calcium , prostacyclin and nitric_oxide by bradykinin and the ACE inhibitor ramiprilat in porcine brain capillary endothelial cells .
7683612	0	calcium	12,19	bradykinin	74,84	calcium	bradykinin	MESH:D002118	3827	Chemical	Gene	role|nmod|START_ENTITY alkalinization|nsubj|role alkalinization|nmod|END_ENTITY	The role of calcium in cell shrinkage and intracellular alkalinization by bradykinin in Ha-ras oncogene expressing cells .
7712026	0	calcium	48,55	bradykinin	75,85	calcium	bradykinin	MESH:D002118	3827	Chemical	Gene	signals|compound|START_ENTITY signals|acl|induced induced|nmod|END_ENTITY	Potentiation by tumour necrosis factor-alpha of calcium signals induced by bradykinin and carbachol in human tracheal smooth muscle cells .
7836425	0	calcium	46,53	bradykinin	11,21	calcium	bradykinin	MESH:D002118	3827	Chemical	Gene	homeostasis|compound|START_ENTITY Effects|nmod|homeostasis Effects|nmod|END_ENTITY	Effects of bradykinin and endothelin-1 on the calcium homeostasis of mammalian cells .
7946358	0	calcium	59,66	bradykinin	78,88	calcium	bradykinin	MESH:D002118	3827	Chemical	Gene	current|compound|START_ENTITY inhibition|nmod|current mediates|dobj|inhibition mediates|nmod|END_ENTITY	The G protein G13 mediates inhibition of voltage-dependent calcium current by bradykinin .
8050477	0	calcium	88,95	bradykinin	21,31	calcium	bradykinin	MESH:D002118	3827	Chemical	Gene	ions|compound|START_ENTITY pool|nmod|ions depletion|nmod|pool follows|dobj|depletion follows|nsubj|Loss Loss|nmod|responses responses|nmod|END_ENTITY	Loss of responses to bradykinin , ATP or carbachol follows depletion of a shared pool of calcium ions .
8087627	0	calcium	71,78	bradykinin	90,100	calcium	bradykinin	MESH:D002118	3827	Chemical	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Tumor_necrosis_factor_alpha potentiates the increase in cytosolic free calcium induced by bradykinin in guinea-pig tracheal smooth muscle cells .
8697901	0	calcium	59,66	bradykinin	18,28	calcium	bradykinin	MESH:D002118	3827	Chemical	Gene	blocks|dep|START_ENTITY blocks|compound|END_ENTITY	Carbachol but not bradykinin blocks the enkephalin-induced calcium transient in human neuroblastoma SK-N-SH cells .
8872609	0	calcium	102,109	bradykinin	76,86	calcium	bradykinin	MESH:D002118	3827	Chemical	Gene	kinases|compound|START_ENTITY regulation|nmod|kinases response|dep|regulation response|nmod|END_ENTITY	Filamin translocation is an early endothelial cell inflammatory response to bradykinin : regulation by calcium , protein kinases , and protein phosphatases .
3131117	0	calcium	8,15	c-myc	40,45	calcium	c-myc	MESH:D002118	24577(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|expression expression|amod|END_ENTITY	Role of calcium in prolactin-stimulated c-myc gene expression and mitogenesis in Nb2 lymphoma cells .
10790395	0	calcium	114,121	cacophony	151,160	calcium	cacophony	MESH:D002118	32158(Tax:7227)	Chemical	Gene	channel|compound|START_ENTITY allele|nmod|channel include|dobj|allele include|dep|gene gene|dep|END_ENTITY	Genetic modifiers of the Drosophila NSF mutant , comatose , include a temperature-sensitive paralytic allele of the calcium channel alpha1-subunit gene , cacophony .
18391075	0	calcium	88,95	cacophony	61,70	calcium	cacophony	MESH:D002118	32158(Tax:7227)	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|appos|channel	straightjacket is required for the synaptic stabilization of cacophony , a voltage-gated calcium channel alpha1 subunit .
18620543	0	calcium	17,24	calaxin	48,55	calcium	calaxin	MESH:D002118	445787(Tax:7719)	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	A novel neuronal calcium sensor family protein , calaxin , is a potential Ca -LRB- 2 + -RRB- - dependent regulator for the outer arm dynein of metazoan cilia and flagella .
1695565	0	calcium	57,64	calbindin-D9K	15,28	calcium	calbindin-D9K	MESH:D002118	24249(Tax:10116)	Chemical	Gene	Stimulation|nmod|START_ENTITY Stimulation|nmod|expression expression|amod|END_ENTITY	Stimulation of calbindin-D9K -LRB- CaBP9K -RRB- gene expression by calcium and 1,25-dihydroxycholecalciferol in fetal rat duodenal organ culture .
1887908	0	calcium	74,81	calbindin-D9K	34,47	calcium	calbindin-D9K	MESH:D002118	24249(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Abnormal intestinal regulation of calbindin-D9K and calmodulin by dietary calcium in genetic hypertension .
2776187	0	calcium	128,135	calbindin-D9K	64,77	calcium	calbindin-D9K	MESH:D002118	795	Chemical	Gene	absorption|compound|START_ENTITY importance|nmod|absorption Comparison|dep|importance Comparison|nmod|diffusion diffusion|nmod|calcium calcium|nmod|END_ENTITY	Comparison of the enhanced steady-state diffusion of calcium by calbindin-D9K and calmodulin : possible importance in intestinal calcium absorption .
8304050	0	calcium	157,164	calbindin-D9K	86,99	calcium	calbindin-D9K	MESH:D002118	795	Chemical	Gene	transport|compound|START_ENTITY correlation|nmod|transport correlation|dep|trihydroxyvitamin_D3 trihydroxyvitamin_D3|nmod|mRNA mRNA|amod|END_ENTITY	Effect of 1,25,28-trihydroxyvitamin _ D2_and_1 ,24,25 - trihydroxyvitamin_D3 on intestinal calbindin-D9K mRNA and protein : is there a correlation with intestinal calcium transport ?
16246455	0	calcium	2,9	calbindin-D9k	27,40	calcium	calbindin-D9k	MESH:D002118	24249(Tax:10116)	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	A calcium binding protein , calbindin-D9k , is mainly regulated by estrogen in the pituitary gland of rats during estrous cycle .
17696760	0	calcium	88,95	calbindin-D9k	15,28	calcium	calbindin-D9k	MESH:D002118	12309(Tax:10090)	Chemical	Gene	genes|compound|START_ENTITY induction|nmod|genes compensated|nmod|induction compensated|nsubjpass|Phenotype Phenotype|nmod|knockout knockout|amod|END_ENTITY	Phenotype of a calbindin-D9k gene knockout is compensated for by the induction of other calcium transporter genes in a mouse model .
19100715	0	calcium	18,25	calbindin-D9k	91,104	calcium	calbindin-D9k	MESH:D002118	12309(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|OH OH|dep|2D3 2D3|nmod|expression expression|nmod|genes genes|nmod|mice mice|amod|END_ENTITY	Effect of dietary calcium and 1,25 - -LRB- OH -RRB- 2D3 on the expression of calcium transport genes in calbindin-D9k and - D28k double knockout mice .
19100715	0	calcium	64,71	calbindin-D9k	91,104	calcium	calbindin-D9k	MESH:D002118	12309(Tax:10090)	Chemical	Gene	genes|compound|START_ENTITY genes|nmod|mice mice|amod|END_ENTITY	Effect of dietary calcium and 1,25 - -LRB- OH -RRB- 2D3 on the expression of calcium transport genes in calbindin-D9k and - D28k double knockout mice .
19106481	0	calcium	71,78	calbindin-D9k	100,113	calcium	calbindin-D9k	MESH:D002118	12309(Tax:10090)	Chemical	Gene	genes|compound|START_ENTITY genes|nmod|mice mice|amod|END_ENTITY	Dietary calcium and 1,25-dihydroxyvitamin _ D3 regulate transcription of calcium transporter genes in calbindin-D9k knockout mice .
19106481	0	calcium	8,15	calbindin-D9k	100,113	calcium	calbindin-D9k	MESH:D002118	12309(Tax:10090)	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|transcription transcription|nmod|genes genes|nmod|mice mice|amod|END_ENTITY	Dietary calcium and 1,25-dihydroxyvitamin _ D3 regulate transcription of calcium transporter genes in calbindin-D9k knockout mice .
2717621	0	calcium	108,115	calbindin-D9k	23,36	calcium	calbindin-D9k	MESH:D002118	24249(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY implications|nmod|transport changes|dep|implications changes|nmod|END_ENTITY	Gestational changes in calbindin-D9k in rat uterus , yolk sac , and placenta : implications for maternal-fetal calcium transport and uterine muscle function .
9089784	0	calcium	88,95	calbindin-D9k	113,126	calcium	calbindin-D9k	MESH:D002118	100526799	Chemical	Gene	protein|compound|START_ENTITY protein|dep|END_ENTITY	Genetic regulation of placental function : a quantitative in situ hybridization study of calcium binding protein -LRB- calbindin-D9k -RRB- and calcium ATPase mRNAs in sheep placenta .
9829361	0	calcium	40,47	calbindin-D9k	81,94	calcium	calbindin-D9k	MESH:D002118	24249(Tax:10116)	Chemical	Gene	absorption|compound|START_ENTITY absorption|nmod|END_ENTITY	Dietary fructooligosaccharides increase calcium absorption and levels of mucosal calbindin-D9k in the large intestine of gastrectomized rats .
14622990	0	calcium	26,33	calbindin_D-9k	48,62	calcium	calbindin D-9k	MESH:D002118	24249(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of age and dietary calcium on intestinal calbindin_D-9k expression in the rat .
1378812	0	calcium	99,106	calcitonin	22,32	calcium	calcitonin	MESH:D002118	24241(Tax:10116)	Chemical	Gene	BAY_K_8644|compound|START_ENTITY effect|nmod|BAY_K_8644 effect|nmod|secretion secretion|nmod|END_ENTITY	In vitro secretion of calcitonin from a rat C cell line : effect of repetitive stimulation with the calcium channel agonist BAY_K_8644 .
1538059	0	calcium	24,31	calcitonin	53,63	calcium	calcitonin	MESH:D002118	24241(Tax:10116)	Chemical	Gene	Concentration|nmod|START_ENTITY Concentration|nmod|END_ENTITY	Concentration of plasma calcium in response to human calcitonin in female rats during aging .
21335070	0	calcium	77,84	calcitonin	31,41	calcium	calcitonin	MESH:D002118	24241(Tax:10116)	Chemical	Gene	currents|compound|START_ENTITY Additive|nmod|currents Additive|dobj|effects effects|nmod|END_ENTITY	Additive inhibitory effects of calcitonin and capsaicin on voltage activated calcium channel currents in nociceptive neurones of rat .
2473933	0	calcium	82,89	calcitonin	30,40	calcium	calcitonin	MESH:D002118	24241(Tax:10116)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|desensitization desensitization|nmod|END_ENTITY	Reversible desensitization of calcitonin secretion by repetitive stimulation with calcium .
2583674	0	calcium	92,99	calcitonin	58,68	calcium	calcitonin	MESH:D002118	24241(Tax:10116)	Chemical	Gene	stimulation|compound|START_ENTITY provoked|nmod|stimulation mRNA|acl|provoked mRNA|compound|END_ENTITY	Actinomycin_D inhibits the rapid increase in translatable calcitonin mRNA provoked by acute calcium stimulation .
2744232	0	calcium	37,44	calcitonin	10,20	calcium	calcitonin	MESH:D002118	24241(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY Effect|nmod|transport Effect|nmod|END_ENTITY	Effect of calcitonin on exchangeable calcium transport in isolated rat hepatocytes .
3094310	0	calcium	4,11	calcitonin	68,78	calcium	calcitonin	MESH:D002118	24241(Tax:10116)	Chemical	Gene	diltiazem|compound|START_ENTITY inhibits|nsubj|diltiazem inhibits|dobj|calcification calcification|acl|enhanced enhanced|nmod|END_ENTITY	The calcium antagonist diltiazem inhibits calcification enhanced by calcitonin in growth cartilage of rats in ethane-1-hydroxy-1 ,1 - diphosphonate -LRB- EHDP -RRB- - induced rickets .
3498624	0	calcium	23,30	calcitonin	65,75	calcium	calcitonin	MESH:D002118	24241(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY concentration|nmod|secretion secretion|nmod|END_ENTITY	Role of cytosolic free calcium concentration in the secretion of calcitonin gene-related peptide and calcitonin from medullary_thyroid_carcinoma cells .
3620946	0	calcium	108,115	calcitonin	66,76	calcium	calcitonin	MESH:D002118	24241(Tax:10116)	Chemical	Gene	control|nmod|START_ENTITY evidence|nmod|control Induction|dep|evidence Induction|nmod|hypocalcemia hypocalcemia|nmod|injection injection|nmod|END_ENTITY	Induction of hypocalcemia by intracerebroventricular injection of calcitonin : evidence for control of blood calcium by the nervous system .
3778886	0	calcium	29,36	calcitonin	15,25	calcium	calcitonin	MESH:D002118	24241(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY effects|nmod|uptake effects|nmod|END_ENTITY	The effects of calcitonin on calcium uptake and respiration in rat-liver mitochondria .
436794	0	calcium	49,56	calcitonin	11,21	calcium	calcitonin	MESH:D002118	24241(Tax:10116)	Chemical	Gene	excretion|compound|START_ENTITY Effects|nmod|excretion Effects|nmod|hormones hormones|amod|END_ENTITY	Effects of calcitonin and other hormones on bile calcium excretion in thyroparathyroidectomized rats .
7288558	0	calcium	48,55	calcitonin	15,25	calcium	calcitonin	MESH:D002118	24241(Tax:10116)	Chemical	Gene	excretion|compound|START_ENTITY Interaction|nmod|excretion Interaction|nmod|END_ENTITY	Interaction of calcitonin and histamine on bile calcium excretion in thyroparathyroidectomized rats .
8454164	0	calcium	13,20	calcitonin	53,63	calcium	calcitonin	MESH:D002118	396256(Tax:9031)	Chemical	Gene	diet|compound|START_ENTITY diet|nmod|expression expression|compound|END_ENTITY	Influence of calcium and vitamin_D deficient diet on calcitonin gene expression in the ultimobranchial cells of the developing chicken .
8546861	0	calcium	31,38	calcitonin	10,20	calcium	calcitonin	MESH:D002118	24241(Tax:10116)	Chemical	Gene	matrices|compound|START_ENTITY elevated|dobj|matrices elevated|nsubj|Effect Effect|nmod|END_ENTITY	Effect of calcitonin , elevated calcium and extracellular matrices on superoxide anion production by rat osteoclasts .
15979760	0	calcium	106,113	calcitonin_gene-related_peptide	39,70	calcium	calcitonin gene-related peptide	MESH:D002118	796	Chemical	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	Determination of the site of action of calcitonin_gene-related_peptide in the alteration of intracellular calcium levels in adult and neonatal rodent myocytes .
1709003	0	calcium	130,137	calcitonin_gene-related_peptide	27,58	calcium	calcitonin gene-related peptide	MESH:D002118	24241(Tax:10116)	Chemical	Gene	influx|compound|START_ENTITY assessed|nmod|influx acts|advcl|assessed acts|nmod|neurons neurons|amod|END_ENTITY	Histamine acts directly on calcitonin_gene-related_peptide - and substance P-containing trigeminal ganglion neurons as assessed by calcium influx and immunocytochemistry .
18762885	0	calcium	12,19	calcitonin_gene-related_peptide	52,83	calcium	calcitonin gene-related peptide	MESH:D002118	24241(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	The role of calcium in endotoxin-induced release of calcitonin_gene-related_peptide -LRB- CGRP -RRB- from rat spinal cord .
20955764	0	calcium	23,30	calcitonin_gene-related_peptide	43,74	calcium	calcitonin gene-related peptide	MESH:D002118	24241(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY gated|dobj|channels gated|nmod|release release|amod|END_ENTITY	Role for voltage gated calcium channels in calcitonin_gene-related_peptide release in the rat trigeminovascular system .
2363727	0	calcium	59,66	calcitonin_gene-related_peptide	17,48	calcium	calcitonin gene-related peptide	MESH:D002118	24241(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY effect|nmod|levels effect|nmod|END_ENTITY	A dual effect of calcitonin_gene-related_peptide on plasma calcium levels in the chick .
3265772	0	calcium	8,15	calcitonin_gene-related_peptide	49,80	calcium	calcitonin gene-related peptide	MESH:D002118	24241(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|content content|nmod|END_ENTITY	Dietary calcium modulates spinal cord content of calcitonin_gene-related_peptide in the rat .
9685362	0	calcium	58,65	calcitonin_gene-related_peptide	82,113	calcium	calcitonin gene-related peptide	MESH:D002118	796	Chemical	Gene	mobilization|compound|START_ENTITY Galphaq/11|nmod|mobilization phospholipase_C-beta1|nmod|Galphaq/11 Activation|nmod|phospholipase_C-beta1 Activation|nmod|END_ENTITY	Activation of phospholipase_C-beta1 via Galphaq/11 during calcium mobilization by calcitonin_gene-related_peptide .
3595520	0	calcium	22,29	calcium-binding_protein	53,76	calcium	calcium-binding protein	MESH:D002118	29177(Tax:10116)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation by dietary calcium of vitamin_D-dependent calcium-binding_protein and active calcium transport in the small intestine of lactating rats .
6829752	0	calcium	12,19	calcium-binding_protein	44,67	calcium	calcium-binding protein	MESH:D002118	1068	Chemical	Gene	diffusion|compound|START_ENTITY Facilitated|dobj|diffusion Facilitated|nmod|END_ENTITY	Facilitated calcium diffusion by intestinal calcium-binding_protein .
6897035	0	calcium	105,112	calcium-binding_protein	21,44	calcium	calcium-binding protein	MESH:D002118	1068	Chemical	Gene	mechanism|compound|START_ENTITY D3|nmod|mechanism induced|nmod|D3 induced|nsubj|role role|nmod|END_ENTITY	The possible role of calcium-binding_protein induced by 1 alpha,25-dihydroxyvitamin _ D3 in the intestinal calcium transport mechanism .
10405337	0	calcium	19,26	calcium-sensing_receptor	93,117	calcium	calcium-sensing receptor	MESH:D002118	12374(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|acting acting|nmod|END_ENTITY	High extracellular calcium inhibits osteoclast-like cell formation by directly acting on the calcium-sensing_receptor existing in osteoclast precursor cells .
10811290	0	calcium	67,74	calcium-sensing_receptor	14,38	calcium	calcium-sensing receptor	MESH:D002118	846	Chemical	Gene	levels|compound|START_ENTITY polymorphisms|nmod|levels polymorphisms|amod|END_ENTITY	The effect of calcium-sensing_receptor gene polymorphisms on serum calcium levels : a familial hypocalciuric hypercalcemia family without mutation in the calcium-sensing_receptor gene .
10811290	0	calcium	67,74	calcium-sensing_receptor	153,177	calcium	calcium-sensing receptor	MESH:D002118	846	Chemical	Gene	levels|compound|START_ENTITY polymorphisms|nmod|levels effect|nmod|polymorphisms effect|dep|family family|nmod|mutation mutation|nmod|gene gene|amod|END_ENTITY	The effect of calcium-sensing_receptor gene polymorphisms on serum calcium levels : a familial hypocalciuric hypercalcemia family without mutation in the calcium-sensing_receptor gene .
12050233	0	calcium	86,93	calcium-sensing_receptor	182,206	calcium	calcium-sensing receptor	MESH:D002118	846	Chemical	Gene	correlation|nmod|START_ENTITY autosomal_dominant_hypocalcemia|nmod|correlation family|nmod|autosomal_dominant_hypocalcemia family|dep|identification identification|nmod|gain gain|nmod|mutation mutation|nmod|END_ENTITY	A family of autosomal_dominant_hypocalcemia with a positive correlation between serum calcium and magnesium : identification of a novel gain of function mutation -LRB- Ser -LRB- 820 -RRB- Phe -RRB- in the calcium-sensing_receptor .
12107202	0	calcium	48,55	calcium-sensing_receptor	130,154	calcium	calcium-sensing receptor	MESH:D002118	846	Chemical	Gene	excretion|compound|START_ENTITY excretion|nmod|patients patients|nmod|mutations mutations|nmod|gene gene|amod|END_ENTITY	Hydrochlorothiazide effectively reduces urinary calcium excretion in two Japanese patients with gain-of-function mutations of the calcium-sensing_receptor gene .
12239240	0	calcium	54,61	calcium-sensing_receptor	13,37	calcium	calcium-sensing receptor	MESH:D002118	846	Chemical	Gene	excretion|compound|START_ENTITY Influence|nmod|excretion Influence|nmod|gene gene|amod|END_ENTITY	Influence of calcium-sensing_receptor gene on urinary calcium excretion in stone-forming patients .
12671051	0	calcium	52,59	calcium-sensing_receptor	4,28	calcium	calcium-sensing receptor	MESH:D002118	12374(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY required|nmod|homeostasis required|nsubjpass|END_ENTITY	The calcium-sensing_receptor is required for normal calcium homeostasis independent of parathyroid_hormone .
15613438	0	calcium	54,61	calcium-sensing_receptor	149,173	calcium	calcium-sensing receptor	MESH:D002118	846	Chemical	Gene	gastrin|nmod|START_ENTITY gastrin|dep|clue clue|nmod|alteration alteration|nmod|activity activity|amod|END_ENTITY	Increased gastrin and calcitonin secretion after oral calcium or peptones administration in patients with hypercalciuria : a clue to an alteration in calcium-sensing_receptor activity .
16019433	0	calcium	5,12	calcium-sensing_receptor	64,88	calcium	calcium-sensing receptor	MESH:D002118	24247(Tax:10116)	Chemical	Gene	activates|nsubj|START_ENTITY activates|xcomp|potentially potentially|nmod|END_ENTITY	High calcium activates the EGF receptor potentially through the calcium-sensing_receptor in Leydig cancer cells .
17331389	0	calcium	70,77	calcium-sensing_receptor	16,40	calcium	calcium-sensing receptor	MESH:D002118	846	Chemical	Gene	level|compound|START_ENTITY polymorphism|nmod|level polymorphism|nsubj|Association Association|nmod|gene gene|amod|END_ENTITY	-LSB- Association of calcium-sensing_receptor gene polymorphism with serum calcium level in healthy young Han women in Beijing -RSB- .
17823248	0	calcium	170,177	calcium-sensing_receptor	4,28	calcium	calcium-sensing receptor	MESH:D002118	12374(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY mechanism|nmod|transport activity|dep|mechanism isoform|dobj|activity regulates|ccomp|isoform regulates|nsubj|END_ENTITY	The calcium-sensing_receptor regulates plasma membrane calcium adenosine triphosphatase isoform 2 activity in mammary epithelial cells : a mechanism for calcium-regulated calcium transport into milk .
17823248	0	calcium	55,62	calcium-sensing_receptor	4,28	calcium	calcium-sensing receptor	MESH:D002118	12374(Tax:10090)	Chemical	Gene	isoform|dobj|START_ENTITY regulates|ccomp|isoform regulates|nsubj|END_ENTITY	The calcium-sensing_receptor regulates plasma membrane calcium adenosine triphosphatase isoform 2 activity in mammary epithelial cells : a mechanism for calcium-regulated calcium transport into milk .
18556746	0	calcium	103,110	calcium-sensing_receptor	28,52	calcium	calcium-sensing receptor	MESH:D002118	846	Chemical	Gene	influence|nmod|START_ENTITY changes|nmod|influence changes|nmod|END_ENTITY	Simultaneous changes in the calcium-sensing_receptor and the vitamin_D_receptor under the influence of calcium and calcitriol .
19640901	0	calcium	131,138	calcium-sensing_receptor	50,74	calcium	calcium-sensing receptor	MESH:D002118	846	Chemical	Gene	kidney_stone|compound|START_ENTITY molarity|nmod|kidney_stone rise|nmod|molarity limits|dobj|rise limits|nsubj|END_ENTITY	A test of the hypothesis that the collecting duct calcium-sensing_receptor limits rise of urine calcium molarity in hypercalciuric calcium kidney_stone formers .
19640901	0	calcium	96,103	calcium-sensing_receptor	50,74	calcium	calcium-sensing receptor	MESH:D002118	846	Chemical	Gene	molarity|compound|START_ENTITY rise|nmod|molarity limits|dobj|rise limits|nsubj|END_ENTITY	A test of the hypothesis that the collecting duct calcium-sensing_receptor limits rise of urine calcium molarity in hypercalciuric calcium kidney_stone formers .
20052292	0	calcium	21,28	calcium-sensing_receptor	52,76	calcium	calcium-sensing receptor	MESH:D002118	12374(Tax:10090)	Chemical	Gene	involves|nsubj|START_ENTITY involves|dobj|END_ENTITY	Presynaptic external calcium signaling involves the calcium-sensing_receptor in neocortical nerve terminals .
20117086	0	calcium	14,21	calcium-sensing_receptor	131,155	calcium	calcium-sensing receptor	MESH:D002118	846	Chemical	Gene	modulates|compound|START_ENTITY +|nsubj|modulates +|nmod|END_ENTITY	Extracellular calcium modulates in vitro bone marrow-derived Flk-1 + CD34 + progenitor cell chemotaxis and differentiation through a calcium-sensing_receptor .
21566074	0	calcium	90,97	calcium-sensing_receptor	13,37	calcium	calcium-sensing receptor	MESH:D002118	846	Chemical	Gene	homeostasis|compound|START_ENTITY impact|nmod|homeostasis mutations|nmod|impact Mutations|dep|mutations Mutations|nmod|gene gene|amod|END_ENTITY	Mutations of calcium-sensing_receptor gene : two novel mutations and overview of impact on calcium homeostasis .
21966280	0	calcium	121,128	calcium-sensing_receptor	49,73	calcium	calcium-sensing receptor	MESH:D002118	12374(Tax:10090)	Chemical	Gene	actions|nmod|START_ENTITY dependent|nmod|actions dependent|nsubj|phenotypes phenotypes|nmod|cartilage cartilage|nmod|mice mice|amod|END_ENTITY	The abnormal phenotypes of cartilage and bone in calcium-sensing_receptor deficient mice are dependent on the actions of calcium , phosphorus , and PTH .
22017175	0	calcium	50,57	calcium-sensing_receptor	4,28	calcium	calcium-sensing receptor	MESH:D002118	12374(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY END_ENTITY|nmod|homeostasis	The calcium-sensing_receptor beyond extracellular calcium homeostasis : conception , development , adult physiology , and disease .
23782944	0	calcium	91,98	calcium-sensing_receptor	33,57	calcium	calcium-sensing receptor	MESH:D002118	12374(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY alters|dobj|metabolism alters|nsubj|ablation ablation|nmod|END_ENTITY	Mammary-specific ablation of the calcium-sensing_receptor during lactation alters maternal calcium metabolism , milk calcium transport , and neonatal calcium accrual .
23856264	0	calcium	17,24	calcium-sensing_receptor	77,101	calcium	calcium-sensing receptor	MESH:D002118	12374(Tax:10090)	Chemical	Gene	electrolyte|compound|START_ENTITY Control|nmod|electrolyte Control|nmod|END_ENTITY	Control of renal calcium , phosphate , electrolyte , and water excretion by the calcium-sensing_receptor .
24244430	0	calcium	142,149	calcium-sensing_receptor	66,90	calcium	calcium-sensing receptor	MESH:D002118	846	Chemical	Gene	gradient|compound|START_ENTITY ER|nmod|gradient associated|nmod|ER associated|nsubjpass|transduction transduction|nmod|variants variants|nmod|END_ENTITY	Excessive signal transduction of gain-of-function variants of the calcium-sensing_receptor -LRB- CaSR -RRB- are associated with increased ER to cytosol calcium gradient .
24381181	0	calcium	116,123	calcium-sensing_receptor	19,43	calcium	calcium-sensing receptor	MESH:D002118	100499250	Chemical	Gene	exposed|nmod|START_ENTITY exposed|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of the calcium-sensing_receptor in calcium homeostasis in larval zebrafish exposed to low environmental calcium .
24381181	0	calcium	47,54	calcium-sensing_receptor	19,43	calcium	calcium-sensing receptor	MESH:D002118	100499250	Chemical	Gene	homeostasis|compound|START_ENTITY END_ENTITY|nmod|homeostasis	Involvement of the calcium-sensing_receptor in calcium homeostasis in larval zebrafish exposed to low environmental calcium .
24576174	0	calcium	5,12	calcium-sensing_receptor	97,121	calcium	calcium-sensing receptor	MESH:D002118	846	Chemical	Gene	concentration|compound|START_ENTITY promotes|nsubj|concentration promotes|dobj|bone_metastasis bone_metastasis|nmod|renal_cell_carcinomas renal_cell_carcinomas|acl|expressing expressing|dobj|END_ENTITY	High calcium concentration in bones promotes bone_metastasis in renal_cell_carcinomas expressing calcium-sensing_receptor .
24992569	0	calcium	66,73	calcium-sensing_receptor	16,40	calcium	calcium-sensing receptor	MESH:D002118	846	Chemical	Gene	handling|compound|START_ENTITY disorders|nmod|handling role|nmod|disorders role|nmod|END_ENTITY	The role of the calcium-sensing_receptor in disorders of abnormal calcium handling and cardiovascular_disease .
25758239	0	calcium	60,67	calcium-sensing_receptor	107,131	calcium	calcium-sensing receptor	MESH:D002118	846	Chemical	Gene	effects|nmod|START_ENTITY potentiates|dobj|effects potentiates|parataxis|talk talk|nmod|END_ENTITY	Active vitamin_D potentiates the anti-neoplastic effects of calcium in the colon : A cross talk through the calcium-sensing_receptor .
9101368	0	calcium	157,164	calcium-sensing_receptor	34,58	calcium	calcium-sensing receptor	MESH:D002118	100341543(Tax:9986)	Chemical	Gene	reveals|nmod|START_ENTITY reveals|nsubj|Cloning Cloning|nmod|END_ENTITY	Cloning and characterization of a calcium-sensing_receptor from the hypercalcemic_New_Zealand white rabbit reveals unaltered responsiveness to extracellular calcium .
9637715	0	calcium	37,44	calcium-sensing_receptor	63,87	calcium	calcium-sensing receptor	MESH:D002118	12374(Tax:10090)	Chemical	Gene	Regulation|nmod|START_ENTITY metabolism|nsubj|Regulation metabolism|nmod|END_ENTITY	Regulation of murine fetal-placental calcium metabolism by the calcium-sensing_receptor .
9712695	0	calcium	23,30	calcium-sensing_receptor	61,85	calcium	calcium-sensing receptor	MESH:D002118	846	Chemical	Gene	prevent|nsubj|START_ENTITY prevent|dobj|apoptosis apoptosis|nmod|END_ENTITY	Elevated extracellular calcium can prevent apoptosis via the calcium-sensing_receptor .
26076051	0	calcium	69,76	calcium_sensing_receptor	13,37	calcium	calcium sensing receptor	MESH:D002118	846	Chemical	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	Induction of calcium_sensing_receptor in human colon_cancer cells by calcium , vitamin_D and aquamin : Promotion of a more differentiated , less malignant and indolent phenotype .
10841769	0	calcium	75,82	calmodulin	11,21	calcium	calmodulin	MESH:D002118	24242(Tax:10116)	Chemical	Gene	bind|dobj|START_ENTITY bind|nsubj|mutants mutants|compound|END_ENTITY	Paramecium calmodulin mutants defective in ion channel regulation can bind calcium and undergo calcium-induced conformational switching .
10850806	0	calcium	73,80	calmodulin	131,141	calcium	calmodulin	MESH:D002118	808	Chemical	Gene	domains|compound|START_ENTITY association|nmod|domains association|dep|studies studies|nmod|fragments fragments|nmod|END_ENTITY	Peptide and metal ion-dependent association of isolated helix-loop-helix calcium binding domains : studies of thrombic fragments of calmodulin .
11170410	0	calcium	108,115	calmodulin	11,21	calcium	calmodulin	MESH:D002118	808	Chemical	Gene	absence|nmod|START_ENTITY melittin|nmod|absence mutants|nmod|melittin mutants|nsubj|END_ENTITY	Paramecium calmodulin mutants defective in ion channel regulation associate with melittin in the absence of calcium but require it for tertiary collapse .
12208465	0	calcium	24,31	calmodulin	46,56	calcium	calmodulin	MESH:D002118	808	Chemical	Gene	transients|compound|START_ENTITY transients|nmod|antagonists antagonists|compound|END_ENTITY	Increased intracellular calcium transients by calmodulin antagonists differentially modulate tumor_necrosis_factor-alpha-induced E-selectin and ICAM-1 expression .
1420336	0	calcium	80,87	calmodulin	16,26	calcium	calmodulin	MESH:D002118	808	Chemical	Gene	complex|compound|START_ENTITY myosin_light-chain_kinase|nmod|complex END_ENTITY|dep|myosin_light-chain_kinase	The heterodimer calmodulin : myosin_light-chain_kinase as a prototype vertebrate calcium signal transduction complex .
1510964	0	calcium	30,37	calmodulin	116,126	calcium	calmodulin	MESH:D002118	36329(Tax:7227)	Chemical	Gene	studies|nmod|START_ENTITY +|nsubj|studies +|dobj|mutants mutants|nmod|END_ENTITY	Circular dichroism studies on calcium binding to two series of Ca2 + binding site mutants of Drosophila_melanogaster calmodulin .
15253872	0	calcium	36,43	calmodulin	66,76	calcium	calmodulin	MESH:D002118	808	Chemical	Gene	regulator|compound|START_ENTITY Cloning|nmod|regulator Cloning|dep|END_ENTITY	Cloning and expression of a pivotal calcium metabolism regulator : calmodulin involved in shell formation from pearl oyster -LRB- Pinctada fucata -RRB- .
15654746	0	calcium	88,95	calmodulin	58,68	calcium	calmodulin	MESH:D002118	808	Chemical	Gene	activation|compound|START_ENTITY stabilized|nmod|activation stabilized|nsubjpass|motion motion|nmod|A A|nmod|domain domain|nmod|END_ENTITY	Dynamic motion of helix A in the amino-terminal domain of calmodulin is stabilized upon calcium activation .
1576994	0	calcium	24,31	calmodulin	106,116	calcium	calmodulin	MESH:D002118	36329(Tax:7227)	Chemical	Gene	studies|nmod|START_ENTITY dissociation|nsubj|studies dissociation|nmod|mutants mutants|nmod|END_ENTITY	Stopped-flow studies of calcium dissociation from calcium-binding-site mutants of Drosophila_melanogaster calmodulin .
16274254	0	calcium	99,106	calmodulin	44,54	calcium	calmodulin	MESH:D002118	808	Chemical	Gene	region|nmod|START_ENTITY region|compound|END_ENTITY	Calmodulin regulation and identification of calmodulin binding region of type-3 ryanodine receptor calcium release channel .
17173306	0	calcium	28,35	calmodulin	91,101	calcium	calmodulin	MESH:D002118	808	Chemical	Gene	changes|nmod|START_ENTITY changes|nmod|fragment fragment|nmod|END_ENTITY	Conformational changes upon calcium binding and phosphorylation in a synthetic fragment of calmodulin .
17661504	0	calcium	11,18	calmodulin	64,74	calcium	calmodulin	MESH:D002118	808	Chemical	Gene	ions|compound|START_ENTITY Binding|nmod|ions Binding|nmod|loops loops|nmod|END_ENTITY	Binding of calcium and other metal ions to the EF-hand loops of calmodulin studied by quantum chemical calculations and molecular dynamics simulations .
17713923	0	calcium	101,108	calmodulin	45,55	calcium	calmodulin	MESH:D002118	808	Chemical	Gene	channel|compound|START_ENTITY inhibition|nmod|channel induces|dobj|inhibition induces|nsubj|occupancy occupancy|nmod|sites sites|nmod|END_ENTITY	Calcium occupancy of N-terminal sites within calmodulin induces inhibition of the ryanodine_receptor calcium release channel .
1779940	0	calcium	43,50	calmodulin	17,27	calcium	calmodulin	MESH:D002118	24242(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY influence|nmod|transport influence|nmod|antagonists antagonists|compound|END_ENTITY	The influence of calmodulin antagonists on calcium transport and uptake in the rat intestine .
18067319	0	calcium	74,81	calmodulin	110,120	calcium	calmodulin	MESH:D002118	808	Chemical	Gene	affinity|compound|START_ENTITY affinity|nmod|C-domain C-domain|nmod|END_ENTITY	The neuronal voltage-dependent sodium channel type II IQ motif lowers the calcium affinity of the C-domain of calmodulin .
18075677	0	calcium	9,16	calmodulin	36,46	calcium	calmodulin	MESH:D002118	808	Chemical	Gene	sites|compound|START_ENTITY make|nsubj|sites make|dobj|multifunctional multifunctional|compound|END_ENTITY	Multiple calcium binding sites make calmodulin multifunctional .
18175310	0	calcium	83,90	calmodulin	29,39	calcium	calmodulin	MESH:D002118	808	Chemical	Gene	affinity|compound|START_ENTITY increases|dobj|affinity increases|nsubj|cooperativity cooperativity|nmod|END_ENTITY	Interdomain cooperativity of calmodulin bound to melittin preferentially increases calcium affinity of sites I and II .
19069660	0	calcium	38,45	calmodulin	64,74	calcium	calmodulin	MESH:D002118	12314(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of Atrazine on the content of calcium and expression of calmodulin in splenocytes of mice -RSB- .
19106618	0	calcium	36,43	calmodulin	65,75	calcium	calmodulin	MESH:D002118	808	Chemical	Gene	channel|compound|START_ENTITY properties|nmod|channel activated|nsubj|properties activated|nmod|END_ENTITY	Functional properties of the CaV1 .2 calcium channel activated by calmodulin in the absence of alpha2delta subunits .
2044154	0	calcium	40,47	calmodulin	4,14	calcium	calmodulin	MESH:D002118	852406(Tax:4932)	Chemical	Gene	function|nmod|START_ENTITY function|nsubj|END_ENTITY	Can calmodulin function without binding calcium ?
22280008	0	calcium	68,75	calmodulin	159,169	calcium	calmodulin	MESH:D002118	852406(Tax:4932)	Chemical	Gene	calmodulin|nmod|START_ENTITY structures|nmod|calmodulin peptide-bound|nsubj|structures peptide-bound|ccomp|reveal reveal|xcomp|vertebrate vertebrate|dobj|END_ENTITY	Solution structures of yeast Saccharomyces_cerevisiae calmodulin in calcium - and target peptide-bound states reveal similarities and differences to vertebrate calmodulin .
23437200	0	calcium	27,34	calmodulin	51,61	calcium	calmodulin	MESH:D002118	808	Chemical	Gene	Identification|nmod|START_ENTITY binding|nsubj|Identification binding|dobj|END_ENTITY	Identification of cellular calcium binding protein calmodulin as a regulator of rotavirus_A infection during comparative proteomic study .
23811053	0	calcium	62,69	calmodulin	14,24	calcium	calmodulin	MESH:D002118	808	Chemical	Gene	function|compound|START_ENTITY voltage-gated|dobj|function voltage-gated|nsubj|states states|nmod|CaV1 CaV1|compound|END_ENTITY	Apo states of calmodulin and CaBP1 control CaV1 voltage-gated calcium channel function through direct competition for the IQ domain .
2391767	0	calcium	48,55	calmodulin	23,33	calcium	calmodulin	MESH:D002118	326597(Tax:9913)	Chemical	Gene	activation|nmod|START_ENTITY activation|nsubj|comparison comparison|nmod|END_ENTITY	A 1H-NMR comparison of calmodulin activation by calcium and by cadmium .
24420770	0	calcium	53,60	calmodulin	80,90	calcium	calmodulin	MESH:D002118	808	Chemical	Gene	channel|nmod|START_ENTITY Activation|nmod|channel mediated|nsubjpass|Activation mediated|nmod|END_ENTITY	Activation of the Ano1 -LRB- TMEM16A -RRB- chloride channel by calcium is not mediated by calmodulin .
24489773	0	calcium	47,54	calmodulin	17,27	calcium	calmodulin	MESH:D002118	808	Chemical	Gene	triggered|nmod|START_ENTITY Pivoting|dep|triggered Pivoting|nmod|lobes lobes|compound|END_ENTITY	Pivoting between calmodulin lobes triggered by calcium in the Kv7 .2 / calmodulin complex .
24489773	0	calcium	47,54	calmodulin	68,78	calcium	calmodulin	MESH:D002118	808	Chemical	Gene	triggered|nmod|START_ENTITY Pivoting|dep|triggered Pivoting|nsubj|complex complex|compound|END_ENTITY	Pivoting between calmodulin lobes triggered by calcium in the Kv7 .2 / calmodulin complex .
24563457	0	calcium	45,52	calmodulin	94,104	calcium	calmodulin	MESH:D002118	808	Chemical	Gene	regulation|nmod|START_ENTITY release|nsubj|regulation release|nmod|mutants mutants|compound|END_ENTITY	Divergent regulation of ryanodine_receptor 2 calcium release channels by arrhythmogenic human calmodulin missense mutants .
24713697	0	calcium	37,44	calmodulin	67,77	calcium	calmodulin	MESH:D002118	808	Chemical	Gene	properties|amod|START_ENTITY properties|nmod|END_ENTITY	Neurogranin alters the structure and calcium binding properties of calmodulin .
2720113	0	calcium	63,70	calmodulin	106,116	calcium	calmodulin	MESH:D002118	326597(Tax:9913)	Chemical	Gene	related|nmod|START_ENTITY peptides|acl|related Conformation|nmod|peptides binding|nsubj|Conformation binding|dobj|III III|nmod|END_ENTITY	Conformation and ion binding properties of peptides related to calcium binding domain III of bovine brain calmodulin .
2996224	0	calcium	79,86	calmodulin	50,60	calcium	calmodulin	MESH:D002118	474584(Tax:9615)	Chemical	Gene	transport|compound|START_ENTITY dissociation|nmod|transport dissociation|nmod|END_ENTITY	-LSB- Cyclic_AMP level , dissociation of membrane-bound calmodulin and regulation of calcium transport in the heart sarcoplasmatic reticulum in circulatory hypoxia -RSB- .
3010874	0	calcium	2,9	calmodulin	141,151	calcium	calmodulin	MESH:D002118	36329(Tax:7227)	Chemical	Gene	protein|compound|START_ENTITY protein|dep|comparison comparison|nmod|protein protein|nmod|END_ENTITY	A calcium binding protein from Drosophila_melanogaster which activates cAMP phosphodiesterase : comparison of this protein with porcine brain calmodulin .
6622516	0	calcium	31,38	calmodulin	50,60	calcium	calmodulin	MESH:D002118	808	Chemical	Gene	binding|nsubj|START_ENTITY binding|nmod|END_ENTITY	Calmodulin antagonists enhance calcium binding to calmodulin .
7857920	0	calcium	32,39	calmodulin	64,74	calcium	calmodulin	MESH:D002118	36329(Tax:7227)	Chemical	Gene	site|compound|START_ENTITY structure|nmod|site Recovery|nmod|structure mutants|nsubj|Recovery mutants|nmod|END_ENTITY	Recovery of native structure by calcium binding site mutants of calmodulin upon binding of sk-MLCK target peptides .
8011644	0	calcium	49,56	calmodulin	71,81	calcium	calmodulin	MESH:D002118	100682497	Chemical	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Resolution of structural changes associated with calcium activation of calmodulin using frequency domain fluorescence spectroscopy .
8679587	0	calcium	80,87	calmodulin	22,32	calcium	calmodulin	MESH:D002118	808	Chemical	Gene	activation|amod|START_ENTITY impact|nmod|activation EF-hand|dep|impact EF-hand|nmod|END_ENTITY	The fourth EF-hand of calmodulin and its helix-loop-helix components : impact on calcium binding and enzyme activation .
8799187	0	calcium	56,63	calmodulin	21,31	calcium	calmodulin	MESH:D002118	808	Chemical	Gene	NCS-1|compound|START_ENTITY targets|nmod|NCS-1 targets|nsubj|modulation modulation|nmod|END_ENTITY	Direct modulation of calmodulin targets by the neuronal calcium sensor NCS-1 .
9422356	0	calcium	89,96	calmodulin	10,20	calcium	calmodulin	MESH:D002118	808	Chemical	Gene	release|nmod|START_ENTITY due|nmod|release cells|amod|due increased|nmod|cells increased|nsubjpass|END_ENTITY	Cytosolic calmodulin is increased in SK-N-SH human neuroblastoma cells due to release of calcium from intracellular stores .
10698163	0	calcium	25,32	calreticulin	117,129	calcium	calreticulin	MESH:D002118	64202(Tax:10116)	Chemical	Gene	status|compound|START_ENTITY END_ENTITY|nmod|status	Influence of the in vivo calcium status on cellular calcium homeostasis and the level of the calcium-binding protein calreticulin in rat hepatocytes .
10698163	0	calcium	52,59	calreticulin	117,129	calcium	calreticulin	MESH:D002118	64202(Tax:10116)	Chemical	Gene	homeostasis|compound|START_ENTITY status|nmod|homeostasis END_ENTITY|nmod|status	Influence of the in vivo calcium status on cellular calcium homeostasis and the level of the calcium-binding protein calreticulin in rat hepatocytes .
15383281	0	calcium	77,84	calreticulin	38,50	calcium	calreticulin	MESH:D002118	811	Chemical	Gene	depletion|compound|START_ENTITY heat_shock|appos|depletion induced|nmod|heat_shock induced|nsubjpass|conformation conformation|nmod|END_ENTITY	A polypeptide binding conformation of calreticulin is induced by heat_shock , calcium depletion , or by deletion of the C-terminal acidic region .
1939344	0	calcium	81,88	calreticulin	59,71	calcium	calreticulin	MESH:D002118	811	Chemical	Gene	protein|compound|START_ENTITY Regulation|appos|protein Regulation|nmod|distribution distribution|nmod|END_ENTITY	Regulation of expression and intracellular distribution of calreticulin , a major calcium binding protein of nonmuscle cells .
20423325	0	calcium	92,99	calreticulin	42,54	calcium	calreticulin	MESH:D002118	811	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|association association|nmod|END_ENTITY	The arginylation-dependent association of calreticulin with stress granules is regulated by calcium .
2583110	0	calcium	83,90	calreticulin	34,46	calcium	calreticulin	MESH:D002118	12317(Tax:10090)	Chemical	Gene	zones|appos|START_ENTITY zones|nmod|sequence sequence|nmod|END_ENTITY	Multiple zones in the sequence of calreticulin -LRB- CRP55 , calregulin , HACBP -RRB- , a major calcium binding ER/SR protein .
8600158	0	calcium	14,21	calreticulin	39,51	calcium	calreticulin	MESH:D002118	64202(Tax:10116)	Chemical	Gene	proteins|compound|START_ENTITY Regulation|nmod|proteins END_ENTITY|nsubj|Regulation	Regulation of calcium binding proteins calreticulin and calsequestrin during differentiation in the myogenic cell line L6 .
9245785	0	calcium	46,53	calreticulin	14,26	calcium	calreticulin	MESH:D002118	12317(Tax:10090)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of calreticulin gene expression by calcium .
9614190	0	calcium	41,48	calreticulin	68,80	calcium	calreticulin	MESH:D002118	64202(Tax:10116)	Chemical	Gene	current|compound|START_ENTITY activation|nmod|current induced|nsubj|activation induced|nmod|overexpression overexpression|compound|END_ENTITY	Delayed activation of the store-operated calcium current induced by calreticulin overexpression in RBL-1 cells .
14715535	0	calcium	9,16	calsequestrin	80,93	calcium	calsequestrin	MESH:D002118	845	Chemical	Gene	signaling|compound|START_ENTITY associated|nsubj|signaling associated|nmod|mutation mutation|nmod|END_ENTITY	Abnormal calcium signaling and sudden_cardiac_death associated with mutation of calsequestrin .
10445100	0	calcium	51,58	caltrin	42,49	calcium	caltrin	MESH:D002118	266602(Tax:10116)	Chemical	Gene	protein|dep|START_ENTITY protein|compound|END_ENTITY	Androgen-dependent synthesis/secretion of caltrin , calcium transport inhibitor protein of mammalian seminal vesicle .
2302400	0	calcium	25,32	caltrin	14,21	calcium	caltrin	MESH:D002118	266602(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|nmod|transport	Inhibition by caltrin of calcium transport into spermatozoa , liver and heart mitochondria .
8318586	0	calcium	76,83	caltrin	63,70	calcium	caltrin	MESH:D002118	266602(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|appos|transport	Isolation and characterization of a 54-kilodalton precursor of caltrin , the calcium transport inhibitor protein from seminal vesicles of the rat .
21219828	0	calcium	33,40	carcinoembryonic_antigen	7,31	calcium	carcinoembryonic antigen	MESH:D002118	1084	Chemical	Gene	levels|compound|START_ENTITY END_ENTITY|appos|levels	Tissue carcinoembryonic_antigen , calcium , copper and iron levels in cancerous_lung patients .
11113122	0	calcium	27,34	cardiac_troponin_C	50,68	calcium	cardiac troponin C	MESH:D002118	7134	Chemical	Gene	sensitizer|nsubj|START_ENTITY sensitizer|nmod|END_ENTITY	Binding of levosimendan , a calcium sensitizer , to cardiac_troponin_C .
12122471	0	calcium	19,26	cardiac_troponin_C	75,93	calcium	cardiac troponin C	MESH:D002118	7134	Chemical	Gene	studies|nmod|START_ENTITY peptide|nsubj|studies peptide|xcomp|binding binding|nmod|END_ENTITY	Kinetic studies of calcium and cardiac_troponin_I peptide binding to human cardiac_troponin_C using NMR spectroscopy .
1737016	0	calcium	83,90	cardiac_troponin_C	53,71	calcium	cardiac troponin C	MESH:D002118	7134	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|changes changes|nmod|sites sites|nmod|END_ENTITY	Conformational changes in the metal-binding sites of cardiac_troponin_C induced by calcium binding .
22329450	0	calcium	13,20	cardiac_troponin_C	78,96	calcium	cardiac troponin C	MESH:D002118	7134	Chemical	Gene	association|compound|START_ENTITY association|nmod|domain domain|nmod|END_ENTITY	Dynamics and calcium association to the N-terminal regulatory domain of human cardiac_troponin_C : a multiscale computational study .
23111626	0	calcium	168,175	cardiac_troponin_C	101,119	calcium	cardiac troponin C	MESH:D002118	7134	Chemical	Gene	sites|compound|START_ENTITY communication|nmod|sites evidence|nmod|communication simulations|dep|evidence simulations|nmod|calcium calcium|amod|binding binding|nmod|site site|nmod|END_ENTITY	Thermodynamics and molecular dynamics simulations of calcium binding to the regulatory site of human cardiac_troponin_C : evidence for communication with the structural calcium binding sites .
23111626	0	calcium	53,60	cardiac_troponin_C	101,119	calcium	cardiac troponin C	MESH:D002118	7134	Chemical	Gene	START_ENTITY|amod|binding binding|nmod|site site|nmod|END_ENTITY	Thermodynamics and molecular dynamics simulations of calcium binding to the regulatory site of human cardiac_troponin_C : evidence for communication with the structural calcium binding sites .
23425245	0	calcium	11,18	cardiac_troponin_C	180,198	calcium	cardiac troponin C	MESH:D002118	7134	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of calcium binding and the hypertrophic_cardiomyopathy A8V mutation on the dynamic equilibrium between closed and open conformations of the regulatory N-domain of isolated cardiac_troponin_C .
2351672	0	calcium	13,20	cardiac_troponin_C	46,64	calcium	cardiac troponin C	MESH:D002118	7134	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of a calcium sensitizer , bepridil , to cardiac_troponin_C .
6882420	0	calcium	66,73	cardiac_troponin_C	82,100	calcium	cardiac troponin C	MESH:D002118	7134	Chemical	Gene	ions|compound|START_ENTITY ions|nmod|END_ENTITY	Enthalpy , entropy and heat capacity changes induced by binding of calcium ions to cardiac_troponin_C .
9828012	0	calcium	41,48	cardiac_troponin_C	21,39	calcium	cardiac troponin C	MESH:D002118	7134	Chemical	Gene	trigger|compound|START_ENTITY cycle|dep|trigger cycle|nmod|END_ENTITY	The kinetic cycle of cardiac_troponin_C : calcium binding and dissociation at site II trigger slow conformational rearrangements .
15646030	0	calcium	102,109	cardiac_troponin_c	127,145	calcium	cardiac troponin c	MESH:D002118	7134	Chemical	Gene	sensitiser|compound|START_ENTITY levosimendan|appos|sensitiser interaction|nmod|levosimendan apparatus|dep|interaction apparatus|nmod|END_ENTITY	The contractile apparatus as a target for drugs against heart_failure : interaction of levosimendan , a calcium sensitiser , with cardiac_troponin_c .
15533592	0	calcium	156,163	caspase_3	112,121	calcium	caspase 3	MESH:D002118	836	Chemical	Gene	role|nmod|START_ENTITY activation|dep|role activation|amod|END_ENTITY	Beauvericin induces cytotoxic effects in human acute_lymphoblastic_leukemia cells through cytochrome_c release , caspase_3 activation : the causative role of calcium .
12562509	0	calcium	38,45	caspase_8	57,66	calcium	caspase 8	MESH:D002118	64044(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY levels|nmod|END_ENTITY	Ceramide increases mitochondrial free calcium levels via caspase_8 and Bid : role in initiation of cell death .
23892734	0	calcium	88,95	cathepsin-L	19,30	calcium	cathepsin-L	MESH:D002118	25697(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY increases|dobj|release increases|nsubj|END_ENTITY	Trypanosoma_brucei cathepsin-L increases arrhythmogenic sarcoplasmic reticulum-mediated calcium release in rat cardiomyocytes .
16317001	0	calcium	28,35	centrin	53,60	calcium	centrin	MESH:D002118	854431(Tax:4932)	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Structure of the N-terminal calcium sensor domain of centrin reveals the biochemical basis for domain-specific function .
11198153	0	calcium	27,34	cholecystokinin	53,68	calcium	cholecystokinin	MESH:D002118	12424(Tax:10090)	Chemical	Gene	signal|compound|START_ENTITY antioxidants|nmod|signal Effects|nmod|antioxidants induced|nsubj|Effects induced|nmod|END_ENTITY	Effects of antioxidants on calcium signal induced by cholecystokinin in mouse pancreatic acinar cells .
15104368	0	calcium	50,57	cholecystokinin	3,18	calcium	cholecystokinin	MESH:D002118	885	Chemical	Gene	increase|dobj|START_ENTITY increase|nsubj|antagonists antagonists|compound|END_ENTITY	Do cholecystokinin antagonists increase cytosolic calcium in pancreatic acinar cells and thereby promote pancreatitis ?
15502636	0	calcium	52,59	cholecystokinin	72,87	calcium	cholecystokinin	MESH:D002118	25298(Tax:10116)	Chemical	Gene	response|compound|START_ENTITY associated|nmod|response associated|xcomp|END_ENTITY	Changes in IP3_receptor are associated with altered calcium response to cholecystokinin in diabetic rat pancreatic acini .
1805301	0	calcium	40,47	cholecystokinin	11,26	calcium	cholecystokinin	MESH:D002118	25298(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of cholecystokinin on cytosolic calcium in human pancreatic_cancer cells .
8333544	0	calcium	40,47	cholecystokinin	11,26	calcium	cholecystokinin	MESH:D002118	25298(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of cholecystokinin on cytosolic calcium in pancreatic duct segments and ductal cells .
8746946	0	calcium	113,120	cholecystokinin	174,189	calcium	cholecystokinin	MESH:D002118	885	Chemical	Gene	oscillations|compound|START_ENTITY formation|nmod|oscillations inhibits|dobj|formation inhibits|advcl|decreasing decreasing|dobj|affinity-state affinity-state|nmod|receptor receptor|compound|END_ENTITY	Protein kinase C activation inhibits receptor-evoked inositol_trisphosphate formation and induction of cytosolic calcium oscillations by decreasing the affinity-state of the cholecystokinin receptor in pancreatic acinar cells .
8779970	0	calcium	74,81	cholecystokinin	26,41	calcium	cholecystokinin	MESH:D002118	885	Chemical	Gene	channels|compound|START_ENTITY mediated|nmod|channels mediated|nsubjpass|secretion secretion|compound|END_ENTITY	Depolarization-stimulated cholecystokinin secretion is mediated by L-type calcium channels in STC-1 cells .
8795086	0	calcium	39,46	cholecystokinin	59,74	calcium	cholecystokinin	MESH:D002118	100735029	Chemical	Gene	channels|compound|START_ENTITY modulating|dobj|channels Effect|acl|modulating Effect|nmod|contractions contractions|amod|END_ENTITY	Effect of modulating voltage-dependent calcium channels on cholecystokinin and acetylcholine-induced contractions of the guinea_pig gallbladder .
2764102	0	calcium	15,22	chromogranin_A	44,58	calcium	chromogranin A	MESH:D002118	1113	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of calcium with porcine adrenal chromogranin_A -LRB- secretory protein-I -RRB- and chromogranin_B -LRB- secretogranin_I -RRB- .
3022252	0	calcium	12,19	corticotropin_releasing_factor	40,70	calcium	corticotropin releasing factor	MESH:D002118	1392	Chemical	Gene	START_ENTITY|nmod|mechanism mechanism|nmod|END_ENTITY	The role of calcium in the mechanism of corticotropin_releasing_factor mediated ACTH release .
10463387	0	calcium	16,23	cox-2	108,113	calcium	cox-2	MESH:D002118	17709(Tax:10090)	Chemical	Gene	release|compound|START_ENTITY dependent|nsubj|release dependent|nmod|induction induction|amod|END_ENTITY	Cadmium-induced calcium release and prostaglandin_E2 production in neonatal mouse calvaria are dependent on cox-2 induction and protein_kinase_C activation .
18716166	0	calcium	8,15	cyclin_D1	45,54	calcium	cyclin D1	MESH:D002118	12443(Tax:10090)	Chemical	Gene	modulate|nsubj|START_ENTITY modulate|dobj|expression expression|amod|END_ENTITY	Dietary calcium and cholecalciferol modulate cyclin_D1 expression , apoptosis , and tumorigenesis in intestine of adenomatous_polyposis_coli1638N / + _ mice .
16956425	0	calcium	42,49	cyclooxygenase-2	80,96	calcium	cyclooxygenase-2	MESH:D002118	5743	Chemical	Gene	homeostasis|compound|START_ENTITY homeostasis|nmod|mRNA mRNA|amod|END_ENTITY	Effects of dexamethasone and celecoxib on calcium homeostasis and expression of cyclooxygenase-2 mRNA in MG-63 human osteosarcoma cells .
18094075	0	calcium	78,85	cyclooxygenase-2	21,37	calcium	cyclooxygenase-2	MESH:D002118	5743	Chemical	Gene	START_ENTITY|nsubj|induction induction|nmod|expression expression|amod|END_ENTITY	Stretch induction of cyclooxygenase-2 expression in human urothelial cells is calcium - and protein kinase C zeta-dependent .
20452970	0	calcium	106,113	cyclooxygenase-2	171,187	calcium	cyclooxygenase-2	MESH:D002118	5743	Chemical	Gene	remodeling|nmod|START_ENTITY expression|acl|remodeling increases|dobj|expression increases|parataxis|prostacyclin prostacyclin|nsubj|role role|nmod|A A|dep|END_ENTITY	Endothelin-1 -LRB- ET-1 -RRB- increases the expression of remodeling genes in vascular smooth muscle through linked calcium and cAMP pathways : role of a phospholipase A -LRB- 2 -RRB- -LRB- cPLA -LRB- 2 -RRB- -RRB- / cyclooxygenase-2 -LRB- COX-2 -RRB- / prostacyclin receptor-dependent autocrine loop .
20958135	0	calcium	110,117	cyclooxygenase-2	20,36	calcium	cyclooxygenase-2	MESH:D002118	5743	Chemical	Gene	inhibition|compound|START_ENTITY ureter|nmod|inhibition contraction|nmod|ureter decreases|dobj|contraction decreases|nsubj|NS-398 NS-398|dep|inhibitor inhibitor|amod|END_ENTITY	NS-398 -LRB- a selective cyclooxygenase-2 inhibitor -RRB- decreases agonist-induced contraction of the human ureter via calcium channel inhibition .
23774942	0	calcium	145,152	cyclooxygenase-2	87,103	calcium	cyclooxygenase-2	MESH:D002118	5743	Chemical	Gene	signaling|compound|START_ENTITY attenuation|nmod|signaling inhibits|nmod|attenuation inhibits|dobj|expression expression|acl|END_ENTITY	A soft coral natural product , 11-episinulariolide_acetate , inhibits gene expression of cyclooxygenase-2 and interleukin-8 through attenuation of calcium signaling .
9393671	0	calcium	41,48	cyclooxygenase-2	67,83	calcium	cyclooxygenase-2	MESH:D002118	19225(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Sustained increase in intracellular free calcium and activation of cyclooxygenase-2 expression in mouse hepatoma cells treated with dioxin .
9406168	0	calcium	2,9	cysteine_protease	21,38	calcium	cysteine protease	MESH:D002118	170808(Tax:10116)	Chemical	Gene	START_ENTITY|acl|stimulated stimulated|xcomp|END_ENTITY	A calcium stimulated cysteine_protease involved in isoproterenol induced cardiac_hypertrophy .
2148293	0	calcium	126,133	cytochrome_P-450	43,59	calcium	cytochrome P-450	MESH:D002118	4051	Chemical	Gene	inhibition|nmod|START_ENTITY END_ENTITY|nmod|inhibition	The effect of substrates and inhibitors of cytochrome_P-450 on the NADPH inhibition of the ATP-dependent , hepatic , microsomal calcium pump .
15533592	0	calcium	156,163	cytochrome_c	90,102	calcium	cytochrome c	MESH:D002118	54205	Chemical	Gene	role|nmod|START_ENTITY activation|dep|role activation|amod|END_ENTITY	Beauvericin induces cytotoxic effects in human acute_lymphoblastic_leukemia cells through cytochrome_c release , caspase_3 activation : the causative role of calcium .
9525925	0	calcium	12,19	cytosolic_phospholipase_A2	43,69	calcium	cytosolic phospholipase A2	MESH:D002118	5321	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of calcium and phosphorylation of cytosolic_phospholipase_A2 in regulating arachidonic_acid release in macrophages .
20152801	0	calcium	15,22	divalent_metal-ion_transporter-1	38,70	calcium	divalent metal-ion transporter-1	MESH:D002118	4891	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of calcium with the human divalent_metal-ion_transporter-1 .
6159942	0	calcium	19,26	dopamine_beta-hydroxylase	77,102	calcium	dopamine beta-hydroxylase	MESH:D002118	1621	Chemical	Gene	ionophore|compound|START_ENTITY effects|nmod|ionophore effects|nmod|transport transport|nmod|END_ENTITY	The effects of the calcium ionophore , A23187 , on the axoplasmic transport of dopamine_beta-hydroxylase .
7598716	0	calcium	58,65	dopamine_beta-hydroxylase	13,38	calcium	dopamine beta-hydroxylase	MESH:D002118	280758(Tax:9913)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Reduction of dopamine_beta-hydroxylase gene expression by calcium in bovine chromaffin cells .
21566910	0	calcium	10,17	e-cadherin	21,31	calcium	e-cadherin	MESH:D002118	999	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of calcium on e-cadherin expression in breast-tumor cells .
21209365	0	calcium	24,31	eNOS	62,66	calcium	eNOS	MESH:D002118	4846	Chemical	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	-LRB- - -RRB- - Epicatechin induces calcium and translocation independent eNOS activation in arterial endothelial cells .
3201397	0	calcium	60,67	elastin	30,37	calcium	elastin	MESH:D002118	2006	Chemical	Gene	concentration|compound|START_ENTITY effects|nmod|concentration effects|nmod|END_ENTITY	Inhibitory effects of soluble elastin on intraplatelet free calcium concentration .
2174439	0	calcium	37,44	endonexin_II	18,30	calcium	endonexin II	MESH:D002118	308	Chemical	Gene	channels|compound|START_ENTITY forms|dobj|channels forms|nsubj|END_ENTITY	Calcium-activated endonexin_II forms calcium channels across acidic phospholipid bilayer membranes .
2957692	0	calcium	62,69	endonexin_II	46,58	calcium	endonexin II	MESH:D002118	308	Chemical	Gene	protein|amod|START_ENTITY END_ENTITY|appos|protein	Structural and functional characterization of endonexin_II , a calcium - and phospholipid-binding protein .
20599230	0	calcium	77,84	endothelial_nitric_oxide_synthase	113,146	calcium	endothelial nitric oxide synthase	MESH:D002118	4846	Chemical	Gene	channels|compound|START_ENTITY channels|nmod|END_ENTITY	Dual actions of cilnidipine in human internal thoracic artery : inhibition of calcium channels and enhancement of endothelial_nitric_oxide_synthase .
22768143	0	calcium	14,21	endothelial_nitric_oxide_synthase	54,87	calcium	endothelial nitric oxide synthase	MESH:D002118	4846	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|amod|END_ENTITY	Lobe-specific calcium binding in calmodulin regulates endothelial_nitric_oxide_synthase activation .
10100094	0	calcium	15,22	endothelin-1	71,83	calcium	endothelin-1	MESH:D002118	24323(Tax:10116)	Chemical	Gene	blockers|compound|START_ENTITY Effects|nmod|blockers RNA|nsubj|Effects RNA|dobj|expression expression|nmod|synthase synthase|amod|END_ENTITY	Effects of two calcium channel blockers on messenger RNA expression of endothelin-1 and nitric_oxide synthase in cardiovascular tissue of hypertensive rats .
10362619	0	calcium	41,48	endothelin-1	13,25	calcium	endothelin-1	MESH:D002118	1906	Chemical	Gene	Mechanism|dep|START_ENTITY Mechanism|nmod|- -|amod|END_ENTITY	Mechanism of endothelin-1 - -LRB- 1-31 -RRB- - induced calcium signaling in human coronary artery smooth muscle cells .
10453541	0	calcium	12,19	endothelin-1	83,95	calcium	endothelin-1	MESH:D002118	1906	Chemical	Gene	blockers|compound|START_ENTITY Effects|nmod|blockers inhibitors|nsubj|Effects inhibitors|nmod|secretion secretion|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Effects of calcium channel blockers and calmodulin inhibitors on the secretion of endothelin-1 in cultured endothelial cells -RSB- .
10617910	0	calcium	66,73	endothelin-1	137,149	calcium	endothelin-1	MESH:D002118	100009270(Tax:9986)	Chemical	Gene	blocker|compound|START_ENTITY iganidipine|appos|blocker administration|nmod|iganidipine effects|nmod|administration evoked|nsubj|effects evoked|nmod|injection injection|amod|END_ENTITY	Improving effects of topical administration of iganidipine , a new calcium channel blocker , on the impaired visual evoked potential after endothelin-1 injection into the vitreous body of rabbits .
11078351	0	calcium	30,37	endothelin-1	80,92	calcium	endothelin-1	MESH:D002118	24323(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY properties|nmod|channels activated|nsubj|properties activated|advcl|END_ENTITY	Pharmacological properties of calcium entry channels in A7r5 cells activated by endothelin-1 .
11078352	0	calcium	124,131	endothelin-1	65,77	calcium	endothelin-1	MESH:D002118	100009270(Tax:9986)	Chemical	Gene	increase|nmod|START_ENTITY increase|amod|END_ENTITY	Nitric_oxide relaxes the vascular smooth muscle independently of endothelin-1 - and U46619-induced intracellular increase of calcium .
12056553	0	calcium	38,45	endothelin-1	69,81	calcium	endothelin-1	MESH:D002118	100726197	Chemical	Gene	changes|nmod|START_ENTITY induced|nsubj|changes induced|nmod|S6c S6c|amod|END_ENTITY	Simultaneous changes in intracellular calcium and tension induced by endothelin-1 and sarafotoxin S6c in guinea_pig isolated gallbladder : influence of indomethacin .
1293317	0	calcium	45,52	endothelin-1	71,83	calcium	endothelin-1	MESH:D002118	24323(Tax:10116)	Chemical	Gene	paradox|compound|START_ENTITY paradox|nmod|-RSB- -RSB-|amod|binding binding|amod|END_ENTITY	The effects of Ca -LRB- 2 + -RRB- - free perfusion and the calcium paradox on -LSB- 125I -RSB- endothelin-1 binding to rat cardiac membranes .
1331845	0	calcium	150,157	endothelin-1	17,29	calcium	endothelin-1	MESH:D002118	24323(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY involvement|nmod|channels uncouples|dep|involvement uncouples|amod|END_ENTITY	Intraventricular endothelin-1 uncouples the blood flow : metabolism relationship in periventricular structures of the rat brain : involvement of L-type calcium channels .
14517584	0	calcium	40,47	endothelin-1	24,36	calcium	endothelin-1	MESH:D002118	1906	Chemical	Gene	mobility|compound|START_ENTITY END_ENTITY|nmod|mobility	Differential effects of endothelin-1 on calcium mobility in cultured porcine pigment epithelial cells of iris and retina .
14581409	0	calcium	22,29	endothelin-1	42,54	calcium	endothelin-1	MESH:D002118	24323(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|nmod|ventricular ventricular|amod|END_ENTITY	Reinduction of T-type calcium channels by endothelin-1 in failing hearts in vivo and in adult rat ventricular myocytes in vitro .
1472072	0	calcium	77,84	endothelin-1	43,55	calcium	endothelin-1	MESH:D002118	1906	Chemical	Gene	blockers|compound|START_ENTITY influence|nmod|blockers influence|amod|END_ENTITY	Chemotaxis of human blood monocytes toward endothelin-1 and the influence of calcium channel blockers .
15309721	0	calcium	117,124	endothelin-1	11,23	calcium	endothelin-1	MESH:D002118	24323(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY intracellular|dobj|concentration intracellular|nsubj|Effects Effects|nmod|proliferation proliferation|amod|END_ENTITY	Effects of endothelin-1 on hepatic stellate cell proliferation , collagen synthesis and secretion , intracellular free calcium concentration .
19286939	0	calcium	20,27	endothelin-1	90,102	calcium	endothelin-1	MESH:D002118	24323(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY mediate|nsubj|channels mediate|nmod|END_ENTITY	Voltage-independent calcium channels mediate lipopolysaccharide-induced hyporeactivity to endothelin-1 in the rat aorta .
19439521	0	calcium	24,31	endothelin-1	56,68	calcium	endothelin-1	MESH:D002118	24323(Tax:10116)	Chemical	Gene	START_ENTITY|acl|signaling signaling|dep|stimulated stimulated|advcl|END_ENTITY	NAADP receptors mediate calcium signaling stimulated by endothelin-1 and norepinephrine in renal afferent arterioles .
2059205	0	calcium	32,39	endothelin-1	87,99	calcium	endothelin-1	MESH:D002118	13614(Tax:10090)	Chemical	Gene	inhibitor|compound|START_ENTITY SK_F|appos|inhibitor inhibits|nsubj|SK_F inhibits|nmod|cells cells|amod|END_ENTITY	SK_F 96365 , a receptor-mediated calcium entry inhibitor , inhibits calcium responses to endothelin-1 in NG108-15 cells .
2059205	0	calcium	66,73	endothelin-1	87,99	calcium	endothelin-1	MESH:D002118	13614(Tax:10090)	Chemical	Gene	responses|compound|START_ENTITY inhibits|dobj|responses inhibits|nmod|cells cells|amod|END_ENTITY	SK_F 96365 , a receptor-mediated calcium entry inhibitor , inhibits calcium responses to endothelin-1 in NG108-15 cells .
21640709	0	calcium	72,79	endothelin-1	16,28	calcium	endothelin-1	MESH:D002118	24323(Tax:10116)	Chemical	Gene	influx|compound|START_ENTITY involves|dobj|influx involves|nsubj|Stretch Stretch|acl|induced induced|dobj|secretion secretion|amod|END_ENTITY	Stretch induced endothelin-1 secretion by adult rat astrocytes involves calcium influx via stretch-activated ion channels -LRB- SACs -RRB- .
2229778	0	calcium	11,18	endothelin-1	76,88	calcium	endothelin-1	MESH:D002118	396915(Tax:9823)	Chemical	Gene	channel|compound|START_ENTITY Effects|nmod|channel blockers|nsubj|Effects blockers|nmod|vasoconstriction vasoconstriction|acl|induced induced|nmod|pigs pigs|amod|END_ENTITY	Effects of calcium channel blockers on coronary vasoconstriction induced by endothelin-1 in closed chest pigs .
22427601	0	calcium	124,131	endothelin-1	38,50	calcium	endothelin-1	MESH:D002118	1906	Chemical	Gene	channels|compound|START_ENTITY rho|nmod|channels role|nmod|rho Constriction|dep|role Constriction|nmod|arterioles arterioles|nmod|END_ENTITY	Constriction of retinal arterioles to endothelin-1 : requisite role of rho kinase independent of protein_kinase_C and L-type calcium channels .
2473283	0	calcium	26,33	endothelin-1	10,22	calcium	endothelin-1	MESH:D002118	24323(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|nmod|channel	Effect of endothelin-1 on calcium channel gating by agonists in vascular smooth muscle .
25873305	0	calcium	68,75	endothelin-1	14,26	calcium	endothelin-1	MESH:D002118	1906	Chemical	Gene	entry|compound|START_ENTITY entry|amod|END_ENTITY	Divergence in endothelin-1 - and bradykinin-activated store-operated calcium entry in afferent sensory neurons .
2684314	0	calcium	11,18	endothelin-1	109,121	calcium	endothelin-1	MESH:D002118	24323(Tax:10116)	Chemical	Gene	blockers|compound|START_ENTITY Effects|nmod|blockers evoked|nsubj|Effects evoked|dobj|Ala1 Ala1|amod|END_ENTITY	Effects of calcium entry blockers on contractions evoked by endothelin-1 , -LSB- Ala3 ,11 -RSB- endothelin-1 and -LSB- Ala1 ,15 -RSB- endothelin-1 in rat isolated aorta .
2684314	0	calcium	11,18	endothelin-1	60,72	calcium	endothelin-1	MESH:D002118	24323(Tax:10116)	Chemical	Gene	blockers|compound|START_ENTITY Effects|nmod|blockers evoked|nsubj|Effects evoked|nmod|Ala3 Ala3|amod|END_ENTITY	Effects of calcium entry blockers on contractions evoked by endothelin-1 , -LSB- Ala3 ,11 -RSB- endothelin-1 and -LSB- Ala1 ,15 -RSB- endothelin-1 in rat isolated aorta .
2684314	0	calcium	11,18	endothelin-1	83,95	calcium	endothelin-1	MESH:D002118	24323(Tax:10116)	Chemical	Gene	blockers|compound|START_ENTITY Effects|nmod|blockers evoked|nsubj|Effects evoked|dobj|Ala1 Ala1|amod|END_ENTITY	Effects of calcium entry blockers on contractions evoked by endothelin-1 , -LSB- Ala3 ,11 -RSB- endothelin-1 and -LSB- Ala1 ,15 -RSB- endothelin-1 in rat isolated aorta .
7498963	0	calcium	106,113	endothelin-1	35,47	calcium	endothelin-1	MESH:D002118	24323(Tax:10116)	Chemical	Gene	influx|nmod|START_ENTITY receptor|nmod|influx mediated|nmod|receptor mediated|nsubjpass|synthesis synthesis|acl|elicited elicited|nmod|END_ENTITY	Prostacyclin synthesis elicited by endothelin-1 in rat aorta is mediated by an ETA receptor via influx of calcium and is independent of protein kinase C .
7509930	0	calcium	14,21	endothelin-1	63,75	calcium	endothelin-1	MESH:D002118	24323(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY Modulators|nmod|channels Modulators|dep|effects effects|nmod|END_ENTITY	Modulators of calcium and potassium channels : their effects on endothelin-1 binding to cardiac membranes .
7615016	0	calcium	11,18	endothelin-1	55,67	calcium	endothelin-1	MESH:D002118	1906	Chemical	Gene	channel|compound|START_ENTITY Effects|nmod|channel blockers|nsubj|Effects blockers|nmod|response response|nmod|END_ENTITY	Effects of calcium channel blockers on the response to endothelin-1 , bradykinin and sodium_nitroprusside in porcine ciliary arteries .
7887328	0	calcium	20,27	endothelin-1	95,107	calcium	endothelin-1	MESH:D002118	100009270(Tax:9986)	Chemical	Gene	antagonist|compound|START_ENTITY Effect|nmod|antagonist induced|nsubj|Effect induced|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Effect of systemic calcium antagonist on a model of ocular circulation disturbance induced by endothelin-1 -RSB- .
8013344	0	calcium	69,76	endothelin-1	20,32	calcium	endothelin-1	MESH:D002118	24323(Tax:10116)	Chemical	Gene	concentrations|compound|START_ENTITY increased|dobj|concentrations increased|nsubj|stimulates stimulates|amod|END_ENTITY	Mechanisms by which endothelin-1 stimulates increased cytosolic free calcium ion concentrations in single rat Sertoli cells .
8117994	0	calcium	27,34	endothelin-1	69,81	calcium	endothelin-1	MESH:D002118	24323(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY evoked|nsubj|role evoked|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- The role of extracellular calcium in the vasoconstriction evoked by endothelin-1 -RSB- .
8207561	0	calcium	60,67	endothelin-1	20,32	calcium	endothelin-1	MESH:D002118	1906	Chemical	Gene	blockade|compound|START_ENTITY effects|nmod|blockade effects|nmod|END_ENTITY	Vascular effects of endothelin-1 in humans and influence of calcium channel blockade .
8267041	0	calcium	22,29	endothelin-1	110,122	calcium	endothelin-1	MESH:D002118	1906	Chemical	Gene	Role|nmod|START_ENTITY venous|nsubj|Role venous|nmod|END_ENTITY	Role of extracellular calcium and calcium channels in the response of human placental venous smooth muscle to endothelin-1 .
9051304	10	calcium	1502,1509	endothelin-1	1448,1460	calcium	endothelin-1	MESH:D002118	24323(Tax:10116)	Chemical	Gene	absence|nmod|START_ENTITY affected|nmod|absence affected|dobj|contraction contraction|acl|induced induced|nmod|END_ENTITY	Neither tyrphostin affected the transient phasic contraction induced by endothelin-1 -LRB- 100 nM -RRB- in the absence of extracellular calcium .
9679163	0	calcium	141,148	endothelin-1	47,59	calcium	endothelin-1	MESH:D002118	24323(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY evidence|nmod|regulation induction|dep|evidence induction|dep|current current|nmod|lung lung|amod|END_ENTITY	Long-term induction of a unique C1 - current by endothelin-1 in an epithelial cell line from rat lung : evidence for regulation of cytoplasmic calcium .
20504745	0	calcium	30,37	endothelin-2	75,87	calcium	endothelin-2	MESH:D002118	13615(Tax:10090)	Chemical	Gene	Mobilization|nmod|START_ENTITY fluxes|nsubj|Mobilization fluxes|nmod|fibroblasts fibroblasts|amod|END_ENTITY	Mobilization of intracellular calcium and stimulation of calcium fluxes by endothelin-2 in cultured mouse swiss 3T3 fibroblasts .
20504745	0	calcium	57,64	endothelin-2	75,87	calcium	endothelin-2	MESH:D002118	13615(Tax:10090)	Chemical	Gene	calcium|nmod|START_ENTITY Mobilization|nmod|calcium fluxes|nsubj|Mobilization fluxes|nmod|fibroblasts fibroblasts|amod|END_ENTITY	Mobilization of intracellular calcium and stimulation of calcium fluxes by endothelin-2 in cultured mouse swiss 3T3 fibroblasts .
8717152	0	calcium	77,84	endothelin-2	14,26	calcium	endothelin-2	MESH:D002118	1907	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of endothelin-2 -LRB- ET-2 -RRB- on migration and changes in cytosolic free calcium of neutrophils .
1490517	0	calcium	36,43	endothelin-3	10,22	calcium	endothelin-3	MESH:D002118	366270(Tax:10116)	Chemical	Gene	level|compound|START_ENTITY Effect|nmod|level Effect|nmod|END_ENTITY	Effect of endothelin-3 on cytosolic calcium level in vascular endothelium and on smooth muscle contraction .
1657061	0	calcium	14,21	endothelin_1	109,121	calcium	endothelin 1	MESH:D002118	1906	Chemical	Gene	mobilization|compound|START_ENTITY Mechanisms|nmod|mobilization hydrolysis|nsubj|Mechanisms hydrolysis|nmod|cells cells|nmod|END_ENTITY	Mechanisms of calcium mobilization and phosphoinositide hydrolysis in human bronchial smooth muscle cells by endothelin_1 .
8834492	0	calcium	27,34	endothelin_1	11,23	calcium	endothelin 1	MESH:D002118	1906	Chemical	Gene	currents|compound|START_ENTITY END_ENTITY|nmod|currents	Effects of endothelin_1 on calcium and sodium currents in isolated human cardiac myocytes .
1847734	0	calcium	83,90	enkephalin	40,50	calcium	enkephalin	MESH:D002118	29237(Tax:10116)	Chemical	Gene	increase|dep|START_ENTITY increase|compound|END_ENTITY	Morphine and -LRB- D-Ala2 , NMe-Phe4 , Gly-ol -RRB- - enkephalin increase the intracellular free calcium in isolated rat myocytes -- effect of naloxone or pretreatment with morphine .
3800950	0	calcium	26,33	enkephalin	106,116	calcium	enkephalin	MESH:D002118	29237(Tax:10116)	Chemical	Gene	Changes|nmod|START_ENTITY Changes|nmod|END_ENTITY	Changes in free cytosolic calcium and accumulation of inositol_phosphates in isolated hepatocytes by -LSB- Leu -RSB- enkephalin .
8830303	0	calcium	71,78	enkephalin	104,114	calcium	enkephalin	MESH:D002118	29237(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY rat|nmod|channels influx|acl|rat inhibited|nsubjpass|influx inhibited|nmod|END_ENTITY	Calcium influx in rat thalamic relay neurons through voltage-dependent calcium channels is inhibited by enkephalin .
10951622	0	calcium	68,75	epidermal_growth_factor	18,41	calcium	epidermal growth factor	MESH:D002118	1950	Chemical	Gene	neurotensin|nmod|START_ENTITY -RSB-|nsubj|neurotensin -RSB-|advcl|-LSB- -LSB-|dobj|influence influence|nmod|END_ENTITY	-LSB- The influence of epidermal_growth_factor , neurotensin on cytosolic calcium and membrane fluidity in carbon_tetrachloride-injured primary cultured hepatocytes -RSB- .
12023512	0	calcium	167,174	epidermal_growth_factor	74,97	calcium	epidermal growth factor	MESH:D002118	1950	Chemical	Gene	homeostasis|compound|START_ENTITY assembly|nmod|homeostasis mediates|nmod|assembly mediates|dobj|effects effects|nmod|END_ENTITY	The beta 1 isoform of protein kinase C mediates the protective effects of epidermal_growth_factor on the dynamic assembly of F-actin cytoskeleton and normalization of calcium homeostasis in human colonic cells .
1585373	0	calcium	72,79	epidermal_growth_factor	14,37	calcium	epidermal growth factor	MESH:D002118	25313(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY modulation|nmod|metabolism modulation|nsubj|END_ENTITY	Lead perturbs epidermal_growth_factor -LRB- EGF -RRB- modulation of intracellular calcium metabolism and collagen synthesis in clonal rat osteoblastic -LRB- ROS 17/2 .8 -RRB- cells .
3259582	0	calcium	42,49	epidermal_growth_factor	61,84	calcium	epidermal growth factor	MESH:D002118	1950	Chemical	Gene	increase|nmod|START_ENTITY Studies|nmod|increase induced|nsubj|Studies induced|nmod|END_ENTITY	Studies on the increase in cytosolic free calcium induced by epidermal_growth_factor , serum , and nucleotides in individual A431 cells .
3502678	0	calcium	62,69	epidermal_growth_factor	10,33	calcium	epidermal growth factor	MESH:D002118	13645(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|infusion infusion|compound|END_ENTITY	Effect of epidermal_growth_factor infusion on serum and urine calcium in mice .
3920969	0	calcium	15,22	epidermal_growth_factor	65,88	calcium	epidermal growth factor	MESH:D002118	1950	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|nmod|transport transport|nmod|END_ENTITY	-LSB- The effect of calcium antagonists on intracellular transport of epidermal_growth_factor and the conjugate of epidermal_growth_factor with pseudomonas exotoxin -RSB- .
6220697	0	calcium	14,21	epidermal_growth_factor	67,90	calcium	epidermal growth factor	MESH:D002118	1950	Chemical	Gene	kinase|compound|START_ENTITY kinase|nmod|END_ENTITY	Activation of calcium and phospholipid-dependent protein kinase by epidermal_growth_factor -LRB- EGF -RRB- in A431 cells : attenuation by 12-0-tetradecanoylphorbol-13-acetate -LRB- TPA -RRB- .
6272837	0	calcium	15,22	epidermal_growth_factor	67,90	calcium	epidermal growth factor	MESH:D002118	1950	Chemical	Gene	Enhancement|nmod|START_ENTITY uptake|nsubj|Enhancement uptake|dobj|turnover turnover|nmod|END_ENTITY	Enhancement of calcium uptake and phosphatidylinositol turnover by epidermal_growth_factor in A-431 cells .
7686480	0	calcium	35,42	epidermal_growth_factor	55,78	calcium	epidermal growth factor	MESH:D002118	25313(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY Regulation|nmod|channels Regulation|nmod|END_ENTITY	Regulation of L-type voltage-gated calcium channels by epidermal_growth_factor .
7699362	0	calcium	24,31	epidermal_growth_factor	70,93	calcium	epidermal growth factor	MESH:D002118	25313(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY regulation|nmod|channels regulation|nmod|END_ENTITY	Long-term regulation of calcium channels in clonal pituitary cells by epidermal_growth_factor , insulin , and glucocorticoids .
8063833	0	calcium	31,38	epidermal_growth_factor	57,80	calcium	epidermal growth factor	MESH:D002118	1950	Chemical	Gene	signals|compound|START_ENTITY sphingolipids|nmod|signals Modulation|nmod|sphingolipids evoked|nsubj|Modulation evoked|nmod|END_ENTITY	Modulation by sphingolipids of calcium signals evoked by epidermal_growth_factor .
8213257	0	calcium	23,30	epidermal_growth_factor	44,67	calcium	epidermal growth factor	MESH:D002118	25313(Tax:10116)	Chemical	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Endothelin-1 modulates calcium signaling by epidermal_growth_factor , alpha-thrombin , and prostaglandin_E1 in UMR-106 osteoblastic cells .
8950780	0	calcium	75,82	epidermal_growth_factor	104,127	calcium	epidermal growth factor	MESH:D002118	1950	Chemical	Gene	stabilize|dobj|START_ENTITY stabilize|nmod|domain domain|compound|END_ENTITY	Functional consequences of mutations in amino_acid residues that stabilize calcium binding to the first epidermal_growth_factor homology domain of human protein_C .
12194021	0	calcium	65,72	epithelial_calcium_channels_1_and_2	102,137	calcium	epithelial calcium channels 1 and 2	MESH:D002118	194352;64177	Chemical	Gene	absorption|compound|START_ENTITY absorption|nmod|END_ENTITY	Na/P -LRB- i -RRB- cotransporter -LRB- Npt2 -RRB- gene disruption increases duodenal calcium absorption and expression of epithelial_calcium_channels_1_and_2 .
20007969	0	calcium	85,92	erythroid_alpha-spectrin	55,79	calcium	erythroid alpha-spectrin	MESH:D002118	20739(Tax:10090)	Chemical	Gene	manner|amod|START_ENTITY END_ENTITY|nmod|manner	Protein 4.2 binds to the carboxyl-terminal EF-hands of erythroid_alpha-spectrin in a calcium - and calmodulin-dependent manner .
10400674	0	calcium	66,73	erythropoietin	22,36	calcium	erythropoietin	MESH:D002118	13856(Tax:10090)	Chemical	Gene	activation|compound|START_ENTITY required|nmod|activation required|nsubj|Identification Identification|nmod|domain domain|compound|END_ENTITY	Identification of the erythropoietin receptor domain required for calcium channel activation .
11528212	0	calcium	50,57	erythropoietin	122,136	calcium	erythropoietin	MESH:D002118	2056	Chemical	Gene	mobilization|compound|START_ENTITY mobilization|nmod|END_ENTITY	Modulation of endothelin-1-induced cytosolic free calcium mobilization and mitogen-activated_protein kinase activation by erythropoietin in vascular smooth muscle cells .
12032187	0	calcium	10,17	erythropoietin	86,100	calcium	erythropoietin	MESH:D002118	24335(Tax:10116)	Chemical	Gene	START_ENTITY|acl|signalling signalling|nmod|therapy therapy|compound|END_ENTITY	Defective calcium signalling in uraemic platelets and its amelioration with long-term erythropoietin therapy .
1284250	0	calcium	91,98	erythropoietin	64,78	calcium	erythropoietin	MESH:D002118	13856(Tax:10090)	Chemical	Gene	syntheses|compound|START_ENTITY effects|nmod|syntheses Regulation|dep|effects Regulation|nmod|death death|nmod|cells cells|nmod|END_ENTITY	Regulation of programmed death in erythroid progenitor cells by erythropoietin : effects of calcium and of protein and RNA syntheses .
14699131	0	calcium	63,70	erythropoietin	34,48	calcium	erythropoietin	MESH:D002118	13856(Tax:10090)	Chemical	Gene	influx|compound|START_ENTITY Interaction|nmod|influx Interaction|nmod|modulation modulation|compound|END_ENTITY	Interaction of TRPC2 and TRPC6 in erythropoietin modulation of calcium influx .
1639525	0	calcium	86,93	erythropoietin	164,178	calcium	erythropoietin	MESH:D002118	2056	Chemical	Gene	concentration|compound|START_ENTITY end-stage_renal_disease|nmod|concentration pressure|nmod|end-stage_renal_disease pressure|nmod|treatment treatment|nmod|renal_anemia renal_anemia|nmod|END_ENTITY	Correlation of blood pressure in end-stage_renal_disease with platelet cytosolic free calcium concentration during treatment of renal_anemia with recombinant human erythropoietin .
1836066	1	calcium	150,157	erythropoietin	189,203	calcium	erythropoietin	MESH:D002118	2056	Chemical	Gene	isradipine|compound|START_ENTITY isradipine|nmod|END_ENTITY	Relationship between serum erythropoietin , blood hemoglobin and lung function -- effect of the calcium antagonist isradipine on serum erythropoietin .
1836066	1	calcium	150,157	erythropoietin	84,98	calcium	erythropoietin	MESH:D002118	2056	Chemical	Gene	isradipine|compound|START_ENTITY effect|nmod|isradipine Relationship|dep|effect Relationship|nmod|END_ENTITY	Relationship between serum erythropoietin , blood hemoglobin and lung function -- effect of the calcium antagonist isradipine on serum erythropoietin .
21376708	0	calcium	43,50	erythropoietin	11,25	calcium	erythropoietin	MESH:D002118	24335(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY END_ENTITY|nmod|concentration	Effects of erythropoietin on intracellular calcium concentration of rat primary cortical neurons .
2189892	0	calcium	32,39	erythropoietin	129,143	calcium	erythropoietin	MESH:D002118	2056	Chemical	Gene	gradients|nsubj|START_ENTITY gradients|nmod|erythroblasts erythroblasts|acl|induced induced|nmod|END_ENTITY	Three-dimensional intracellular calcium gradients in single human burst-forming units-erythroid-derived erythroblasts induced by erythropoietin .
2496770	0	calcium	63,70	erythropoietin	26,40	calcium	erythropoietin	MESH:D002118	13856(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of recombinant erythropoietin on intracellular free calcium in erythropoietin-responsive cells .
3425704	0	calcium	15,22	erythropoietin	33,47	calcium	erythropoietin	MESH:D002118	2056	Chemical	Gene	levels|compound|START_ENTITY Effects|nmod|levels Effects|nmod|production production|compound|END_ENTITY	Effects of low calcium levels on erythropoietin production by human renal_carcinoma cells in culture .
3572802	0	calcium	38,45	erythropoietin	9,23	calcium	erythropoietin	MESH:D002118	24335(Tax:10116)	Chemical	Gene	entry|compound|START_ENTITY production|nmod|entry production|compound|END_ENTITY	Enhanced erythropoietin production by calcium entry blockers in rats exposed to hypoxia .
7800209	0	calcium	33,40	erythropoietin	48,62	calcium	erythropoietin	MESH:D002118	2056	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|therapy therapy|compound|END_ENTITY	Modulation of platelet cytosolic calcium during erythropoietin therapy in uraemia .
7936038	0	calcium	48,55	erythropoietin	5,19	calcium	erythropoietin	MESH:D002118	2056	Chemical	Gene	phosphorus|compound|START_ENTITY levels|compound|phosphorus effect|nmod|levels have|dobj|effect have|nsubj|END_ENTITY	Does erythropoietin have a beneficial effect on calcium , phosphorus and parathyroid hormone levels in pediatric hemodialysis patients ?
8016163	0	calcium	65,72	erythropoietin	14,28	calcium	erythropoietin	MESH:D002118	2056	Chemical	Gene	channels|compound|START_ENTITY involvement|nmod|channels Mechanisms|dep|involvement Mechanisms|nmod|transduction transduction|compound|END_ENTITY	Mechanisms of erythropoietin signal transduction : involvement of calcium channels .
8196222	0	calcium	62,69	erythropoietin	29,43	calcium	erythropoietin	MESH:D002118	2056	Chemical	Gene	concentration|compound|START_ENTITY END_ENTITY|nmod|concentration	-LSB- Effect of recombinant human erythropoietin on cytosolic free calcium concentration in platelets -RSB- .
8606524	0	calcium	48,55	erythropoietin	24,38	calcium	erythropoietin	MESH:D002118	2056	Chemical	Gene	involves|dobj|START_ENTITY involves|nsubj|release release|nmod|END_ENTITY	Endothelin-1 release by erythropoietin involves calcium signaling in endothelial cells .
8773347	0	calcium	130,137	erythropoietin	12,26	calcium	erythropoietin	MESH:D002118	24335(Tax:10116)	Chemical	Gene	change|nmod|START_ENTITY increases|nmod|change increases|nsubj|END_ENTITY	Recombinant erythropoietin increases blood pressure in experimental hypertension and uraemia without change in vascular cytosolic calcium .
8978281	0	calcium	14,21	erythropoietin	57,71	calcium	erythropoietin	MESH:D002118	2056	Chemical	Gene	channels|compound|START_ENTITY Modulation|nmod|channels Modulation|nmod|END_ENTITY	Modulation of calcium channels in human erythroblasts by erythropoietin .
15569417	0	calcium	101,108	estrogen_receptor-alpha	15,38	calcium	estrogen receptor-alpha	MESH:D002118	2099	Chemical	Gene	genotypes|nmod|START_ENTITY genotypes|nsubj|Association Association|nmod|END_ENTITY	Association of estrogen_receptor-alpha and vitamin_D_receptor genotypes with therapeutic response to calcium in postmenopausal Chinese women .
2154987	0	calcium	15,22	fMLP	80,84	calcium	fMLP	MESH:D002118	2357	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of calcium in the thimerosal-stimulated formation of leukotriene by fMLP in human polymorphonuclear leukocytes .
986155	1	calcium	82,89	factor_Xa	115,124	calcium	factor Xa	MESH:D002118	2159	Chemical	Gene	ions|compound|START_ENTITY ions|nmod|END_ENTITY	Polylysine substitutes for calcium ions and factor V in the factor_Xa catalyzed activation of prothrombin .
24028708	0	calcium	25,32	fetuin_A	52,60	calcium	fetuin A	MESH:D002118	197	Chemical	Gene	concentration|compound|START_ENTITY concentration|nmod|level level|compound|END_ENTITY	Association of dialysate calcium concentration with fetuin_A level and carotid intima-media thickness in peritoneal_dialysis patients .
10024441	0	calcium	16,23	fibrillin-1	81,92	calcium	fibrillin-1	MESH:D002118	2200	Chemical	Gene	modulated|nsubj|START_ENTITY modulated|nmod|END_ENTITY	EGF-like domain calcium affinity modulated by N-terminal domain linkage in human fibrillin-1 .
12511552	0	calcium	37,44	fibrillin-1	128,139	calcium	fibrillin-1	MESH:D002118	2200	Chemical	Gene	growth|compound|START_ENTITY structure|nmod|growth factor-like|nsubj|structure factor-like|nmod|region region|nmod|END_ENTITY	Solution structure and dynamics of a calcium binding epidermal growth factor-like domain pair from the neonatal region of human fibrillin-1 .
7896820	0	calcium	4,11	fibrillin-1	107,118	calcium	fibrillin-1	MESH:D002118	2200	Chemical	Gene	properties|amod|START_ENTITY domains|nsubj|properties domains|nmod|END_ENTITY	The calcium binding properties and molecular organization of epidermal growth factor-like domains in human fibrillin-1 .
9887276	0	calcium	10,17	fibrillin-1	78,89	calcium	fibrillin-1	MESH:D002118	2200	Chemical	Gene	START_ENTITY|dep|consequence consequence|nmod|change change|nmod|structure structure|amod|END_ENTITY	Defective calcium binding to fibrillin-1 : consequence of an N2144S change for fibrillin-1 structure and function .
20154	0	calcium	15,22	fibrinogen	26,36	calcium	fibrinogen	MESH:D002118	2244	Chemical	Gene	The|nmod|START_ENTITY The|nmod|END_ENTITY	The binding of calcium to fibrinogen : some structural features .
3160702	0	calcium	29,36	fibrinogen	18,28	calcium	fibrinogen	MESH:D002118	2244	Chemical	Gene	site|compound|START_ENTITY site|amod|END_ENTITY	Localization of a fibrinogen calcium binding site between gamma-subunit positions 311 and 336 by terbium fluorescence .
465525	0	calcium	15,22	fibrinogen	26,36	calcium	fibrinogen	MESH:D002118	2244	Chemical	Gene	The|nmod|START_ENTITY The|nmod|END_ENTITY	The binding of calcium to fibrinogen : influence on the clotting process .
21998324	0	calcium	45,52	galectin-1	64,74	calcium	galectin-1	MESH:D002118	56646(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY channel|nmod|END_ENTITY	Splice variant specific modulation of CaV1 .2 calcium channel by galectin-1 regulates arterial constriction .
1728416	0	calcium	28,35	gamma-interferon	60,76	calcium	gamma-interferon	MESH:D002118	15978(Tax:10090)	Chemical	Gene	concentration|compound|START_ENTITY concentration|nmod|END_ENTITY	Prolonged decrease of serum calcium concentration by murine gamma-interferon in hypercalcemic , human tumor -LRB- EC-GI -RRB- - bearing nude_mice .
104896	0	calcium	57,64	gastrin	14,21	calcium	gastrin	MESH:D002118	2520	Chemical	Gene	changes|nmod|START_ENTITY release|nmod|changes release|nsubj|Modulation Modulation|nmod|END_ENTITY	Modulation of gastrin release by acute changes in plasma calcium .
12448052	0	calcium	35,42	gastrin	13,20	calcium	Gastrin	MESH:D002118	2520	Chemical	Gene	load|compound|START_ENTITY END_ENTITY|nmod|load	-LSB- Response of gastrin after an oral calcium load in healthy women and in postmenopausal patients without hormone replacement therapy -RSB- .
1286691	0	calcium	60,67	gastrin	100,107	calcium	gastrin	MESH:D002118	100685087	Chemical	Gene	effect|nmod|START_ENTITY mechanism|nmod|effect analysis|nmod|mechanism -LSB-|dobj|analysis -LSB-|nmod|release release|nmod|END_ENTITY	-LSB- An analysis of the mechanism of the effect of intragastric calcium and magnesium on the release of gastrin and insulin in dogs -RSB- .
1851825	0	calcium	48,55	gastrin	6,13	calcium	gastrin	MESH:D002118	25320(Tax:10116)	Chemical	Gene	increasing|dobj|START_ENTITY increases|nmod|increasing increases|nsubj|END_ENTITY	Serum gastrin increases with increasing dietary calcium but not with increasing dietary fat or fiber in Fischer-344 rats .
18536954	0	calcium	18,25	gastrin	54,61	calcium	gastrin	MESH:D002118	2520	Chemical	Gene	Activation|nmod|START_ENTITY stimulates|nsubj|Activation stimulates|dobj|secretion secretion|amod|END_ENTITY	Activation of the calcium sensing receptor stimulates gastrin and gastric_acid secretion in healthy participants .
1983423	0	calcium	46,53	gastrin	11,18	calcium	gastrin	MESH:D002118	25320(Tax:10116)	Chemical	Gene	absorption|compound|START_ENTITY Effects|nmod|absorption Effects|nmod|END_ENTITY	Effects of gastrin and secretin on intestinal calcium absorption in the rat .
2465675	0	calcium	8,15	gastrin	27,34	calcium	gastrin	MESH:D002118	25320(Tax:10116)	Chemical	Gene	influences|nsubj|START_ENTITY influences|dobj|END_ENTITY	Ionized calcium influences gastrin stimulated histamine release and acid secretion , but not histamine stimulated acid output in the totally isolated vascularly perfused rat stomach .
2847254	1	calcium	155,162	gastrin	331,338	calcium	gastrin	MESH:D002118	25320(Tax:10116)	Chemical	Gene	involvement|nmod|START_ENTITY reported|dobj|involvement reported|parataxis|potentiated potentiated|dobj|response response|compound|END_ENTITY	We and others have recently reported an involvement of calcium -LRB- Ca2 + -RRB- - mediated intracellular pathways in the release of antral gastrin in response to bombesin -LRB- BBS -RRB- , while cyclic_adenosine_3 ' 5 ' - monophosphate -LRB- cAMP -RRB- potentiated the gastrin response to BBS .
3130276	0	calcium	22,29	gastrin	90,97	calcium	gastrin	MESH:D002118	100714563	Chemical	Gene	mobilizations|compound|START_ENTITY mobilizations|nmod|cell cell|nmod|stimulations stimulations|nmod|END_ENTITY	Initial and sustained calcium mobilizations in the parietal cell during stimulations with gastrin , inositol_trisphosphate , phorbol_ester and exogenous diacylglycerol .
323117	0	calcium	38,45	gastrin	95,102	calcium	gastrin	MESH:D002118	2520	Chemical	Gene	value|nmod|START_ENTITY study|nmod|value increase|nsubj|study increase|nmod|END_ENTITY	Comparative study of the value of the calcium , secretin , and meal stimulated increase in serum gastrin to the diagnosis of the Zollinger-Ellison_syndrome .
6256255	0	calcium	8,15	gastrin	26,33	calcium	gastrin	MESH:D002118	25320(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|release release|compound|END_ENTITY	Role of calcium in antral gastrin release .
6260615	0	calcium	99,106	gastrin	88,95	calcium	gastrin	MESH:D002118	2520	Chemical	Gene	calcitonin|compound|START_ENTITY levels|compound|calcitonin containing|nmod|levels containing|dobj|tetrapeptide tetrapeptide|nmod|END_ENTITY	Effect of exogenous gastrointestinal peptides containing the C-terminal tetrapeptide of gastrin on calcium , calcitonin and parathormone serum levels in man .
6401247	0	calcium	8,15	gastrin	61,68	calcium	gastrin	MESH:D002118	100685087	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|coupling coupling|nmod|release release|compound|END_ENTITY	Role of calcium in the stimulus-secretion coupling of antral gastrin release .
6806138	0	calcium	27,34	gastrin	64,71	calcium	gastrin	MESH:D002118	2520	Chemical	Gene	changes|nmod|START_ENTITY Effect|nmod|changes END_ENTITY|nsubj|Effect	Effect of changes in serum calcium on secretin-stimulated serum gastrin in patients with Zollinger-Ellison_syndrome .
686901	4	calcium	569,576	gastrin	505,512	calcium	gastrin	MESH:D002118	2520	Chemical	Gene	result|dep|START_ENTITY result|nmod|use use|nmod|measurements measurements|compound|END_ENTITY	Earlier diagnosis is the result of liberal use of serum gastrin measurements and provocative tests for gastrin release -LRB- calcium and secretin -RRB- , and an increased awareness of this syndrome .
9277405	0	calcium	7,14	gastrin	33,40	calcium	gastrin	MESH:D002118	2520	Chemical	Gene	channels|compound|START_ENTITY regulate|nsubj|channels regulate|dobj|release release|compound|END_ENTITY	L-type calcium channels regulate gastrin release from human antral G cells .
9812857	0	calcium	19,26	gastrin	38,45	calcium	gastrin	MESH:D002118	25320(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY release|nmod|END_ENTITY	-LSB- Role of cytosolic calcium release on gastrin induced contraction of gastric muscle cells of rat -RSB- .
10600780	0	calcium	68,75	gelsolin	8,16	calcium	gelsolin	MESH:D002118	227753(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY Role|nmod|channels Role|nmod|END_ENTITY	Role of gelsolin in the actin filament regulation of cardiac L-type calcium channels .
12460571	0	calcium	4,11	gelsolin	26,34	calcium	gelsolin	MESH:D002118	2934	Chemical	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	The calcium activation of gelsolin : insights from the 3A structure of the G4-G6 / actin complex .
14519122	0	calcium	42,49	gelsolin	18,26	calcium	gelsolin	MESH:D002118	2934	Chemical	Gene	latch|nsubj|START_ENTITY END_ENTITY|dep|latch	The activation of gelsolin by low pH : the calcium latch is sensitive to calcium but not pH. Gelsolin is a multidomain and multifunction protein that nucleates the assembly of filaments and severs them .
14519122	0	calcium	72,79	gelsolin	18,26	calcium	gelsolin	MESH:D002118	2934	Chemical	Gene	sensitive|nmod|START_ENTITY latch|ccomp|sensitive END_ENTITY|dep|latch	The activation of gelsolin by low pH : the calcium latch is sensitive to calcium but not pH. Gelsolin is a multidomain and multifunction protein that nucleates the assembly of filaments and severs them .
16494841	0	calcium	50,57	gelsolin	118,126	calcium	gelsolin	MESH:D002118	2934	Chemical	Gene	binding|nmod:npmod|START_ENTITY binding|nmod|half half|nmod|END_ENTITY	Targeted molecular dynamics simulation studies of calcium binding and conformational change in the C-terminal half of gelsolin .
25100107	0	calcium	69,76	gelsolin	85,93	calcium	gelsolin	MESH:D002118	2934	Chemical	Gene	ions|compound|START_ENTITY ions|nmod|END_ENTITY	Single-molecule force spectroscopy reveals force-enhanced binding of calcium ions by gelsolin .
2557242	0	calcium	8,15	gelsolin	38,46	calcium	gelsolin	MESH:D002118	2934	Chemical	Gene	sensitivity|compound|START_ENTITY sensitivity|nmod|END_ENTITY	Loss of calcium sensitivity of plasma gelsolin is associated with the presence of calcium ions during preparation .
2557242	0	calcium	82,89	gelsolin	38,46	calcium	gelsolin	MESH:D002118	2934	Chemical	Gene	ions|compound|START_ENTITY presence|nmod|ions associated|nmod|presence associated|nsubjpass|Loss Loss|nmod|sensitivity sensitivity|nmod|END_ENTITY	Loss of calcium sensitivity of plasma gelsolin is associated with the presence of calcium ions during preparation .
2999102	0	calcium	87,94	gelsolin	22,30	calcium	gelsolin	MESH:D002118	2934	Chemical	Gene	ions|compound|START_ENTITY presence|nmod|ions END_ENTITY|nmod|presence	Interaction of plasma gelsolin with G-actin and F-actin in the presence and absence of calcium ions .
7883037	0	calcium	108,115	gelsolin	134,142	calcium	gelsolin	MESH:D002118	2934	Chemical	Gene	START_ENTITY|nmod|control control|nmod|activity activity|compound|END_ENTITY	Identification of the trapped calcium in the gelsolin segment 1-actin complex : implications for the role of calcium in the control of gelsolin activity .
7883037	0	calcium	108,115	gelsolin	45,53	calcium	gelsolin	MESH:D002118	2934	Chemical	Gene	role|nmod|START_ENTITY implications|nmod|role Identification|dep|implications Identification|nmod|calcium calcium|nmod|segment segment|compound|END_ENTITY	Identification of the trapped calcium in the gelsolin segment 1-actin complex : implications for the role of calcium in the control of gelsolin activity .
7883037	0	calcium	30,37	gelsolin	134,142	calcium	gelsolin	MESH:D002118	2934	Chemical	Gene	Identification|nmod|START_ENTITY Identification|dep|implications implications|nmod|role role|nmod|calcium calcium|nmod|control control|nmod|activity activity|compound|END_ENTITY	Identification of the trapped calcium in the gelsolin segment 1-actin complex : implications for the role of calcium in the control of gelsolin activity .
7883037	0	calcium	30,37	gelsolin	45,53	calcium	gelsolin	MESH:D002118	2934	Chemical	Gene	START_ENTITY|nmod|segment segment|compound|END_ENTITY	Identification of the trapped calcium in the gelsolin segment 1-actin complex : implications for the role of calcium in the control of gelsolin activity .
8385009	0	calcium	75,82	gelsolin	13,21	calcium	gelsolin	MESH:D002118	100034186(Tax:9796)	Chemical	Gene	responds|nmod|START_ENTITY responds|nsubj|END_ENTITY	Horse plasma gelsolin labelled with fluorescein_isothiocyanate responds to calcium and actin .
9144396	0	calcium	18,25	gelsolin	53,61	calcium	gelsolin	MESH:D002118	2934	Chemical	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Localization of a calcium sensitive binding site for gelsolin on actin subdomain I : implication for severing process .
9334393	0	calcium	46,53	gelsolin	27,35	calcium	gelsolin	MESH:D002118	227753(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY modulates|dobj|channel modulates|nsubj|END_ENTITY	The actin-severing protein gelsolin modulates calcium channel and NMDA receptor activities and vulnerability to excitotoxicity in hippocampal neurons .
9398317	0	calcium	23,30	gelsolin	34,42	calcium	gelsolin	MESH:D002118	2934	Chemical	Gene	effects|nmod|START_ENTITY Probing|dobj|effects Probing|nmod|END_ENTITY	Probing the effects of calcium on gelsolin .
23160599	0	calcium	40,47	ghrelin	11,18	calcium	ghrelin	MESH:D002118	59301(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY END_ENTITY|nmod|concentration	Effects of ghrelin on the intracellular calcium concentration in rat aorta vascular smooth muscle cells .
4016090	0	calcium	109,116	glyceraldehyde-3-phosphate_dehydrogenase	50,90	calcium	glyceraldehyde-3-phosphate dehydrogenase	MESH:D002118	100009074(Tax:9986)	Chemical	Gene	absence|nmod|START_ENTITY END_ENTITY|nmod|absence	Fusion of phospholipid vesicles induced by muscle glyceraldehyde-3-phosphate_dehydrogenase in the absence of calcium .
10097170	0	calcium	94,101	gonadotropin-releasing_hormone	25,55	calcium	gonadotropin-releasing hormone	MESH:D002118	2796	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|patterns patterns|amod|END_ENTITY	Coordinate regulation of gonadotropin-releasing_hormone neuronal firing patterns by cytosolic calcium and store depletion .
10372699	0	calcium	39,46	gonadotropin-releasing_hormone	92,122	calcium	gonadotropin-releasing hormone	MESH:D002118	2796	Chemical	Gene	bone_demineralization|nmod|START_ENTITY Prevention|nmod|bone_demineralization supplementation|nsubj|Prevention supplementation|nmod|treatment treatment|amod|END_ENTITY	Prevention of bone_demineralization by calcium supplementation in precocious puberty during gonadotropin-releasing_hormone agonist treatment .
10799494	0	calcium	48,55	gonadotropin-releasing_hormone	138,168	calcium	gonadotropin-releasing hormone	MESH:D002118	25194(Tax:10116)	Chemical	Gene	signals|compound|START_ENTITY mediate|nsubj|signals mediate|nmod|END_ENTITY	Divergent signaling pathways requiring discrete calcium signals mediate concurrent activation of two mitogen-activated protein kinases by gonadotropin-releasing_hormone .
12629090	0	calcium	110,117	gonadotropin-releasing_hormone	54,84	calcium	gonadotropin-releasing hormone	MESH:D002118	2796	Chemical	Gene	supplementation|compound|START_ENTITY Bone|nmod|supplementation Bone|nmod|agonist agonist|amod|END_ENTITY	Bone mass at final height in precocious puberty after gonadotropin-releasing_hormone agonist with and without calcium supplementation .
1423532	0	calcium	120,127	gonadotropin-releasing_hormone	78,108	calcium	gonadotropin-releasing hormone	MESH:D002118	25194(Tax:10116)	Chemical	Gene	influx|compound|START_ENTITY depends|nmod|influx depends|nsubj|component component|nmod|calcium calcium|acl|mobilizing mobilizing|nmod|END_ENTITY	Transient but not oscillating component of the calcium mobilizing response to gonadotropin-releasing_hormone depends on calcium influx in pituitary gonadotrophs .
1423532	0	calcium	47,54	gonadotropin-releasing_hormone	78,108	calcium	gonadotropin-releasing hormone	MESH:D002118	25194(Tax:10116)	Chemical	Gene	START_ENTITY|acl|mobilizing mobilizing|nmod|END_ENTITY	Transient but not oscillating component of the calcium mobilizing response to gonadotropin-releasing_hormone depends on calcium influx in pituitary gonadotrophs .
14607578	0	calcium	84,91	gonadotropin-releasing_hormone	10,40	calcium	gonadotropin-releasing hormone	MESH:D002118	2796	Chemical	Gene	metabolism|compound|START_ENTITY Effect|nmod|metabolism Effect|nmod|agonist agonist|amod|END_ENTITY	Effect of gonadotropin-releasing_hormone agonist and medroxyprogesterone_acetate on calcium metabolism : a prospective , randomized , double-blind , placebo-controlled , crossover trial .
15350253	0	calcium	119,126	gonadotropin-releasing_hormone	63,93	calcium	gonadotropin-releasing hormone	MESH:D002118	2796	Chemical	Gene	levels|compound|START_ENTITY stimulated|nmod|levels stimulated|dobj|release release|amod|END_ENTITY	Dependence of 3 ' ,5 ' - cyclic_adenosine_monophosphate -- stimulated gonadotropin-releasing_hormone release on intracellular calcium levels and L-type calcium channels in superfused GT1-7 neurons .
1547730	0	calcium	145,152	gonadotropin-releasing_hormone	15,45	calcium	gonadotropin-releasing hormone	MESH:D002118	2796	Chemical	Gene	responses|compound|START_ENTITY Maintenance|nmod|responses Maintenance|nmod|END_ENTITY	Maintenance of gonadotropin-releasing_hormone -LRB- GnRH -RRB- - stimulated luteinizing hormone release despite desensitization of GnRH-stimulated cytosolic calcium responses .
20237262	0	calcium	73,80	gonadotropin-releasing_hormone	93,123	calcium	gonadotropin-releasing hormone	MESH:D002118	14714(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY channels|nmod|neurons neurons|amod|END_ENTITY	Diurnal in vivo and rapid in vitro effects of estradiol on voltage-gated calcium channels in gonadotropin-releasing_hormone neurons .
20739401	0	calcium	98,105	gonadotropin-releasing_hormone	118,148	calcium	gonadotropin-releasing hormone	MESH:D002118	14714(Tax:10090)	Chemical	Gene	currents|compound|START_ENTITY currents|nmod|neurons neurons|amod|END_ENTITY	Progesterone treatment inhibits and dihydrotestosterone -LRB- DHT -RRB- treatment potentiates voltage-gated calcium currents in gonadotropin-releasing_hormone -LRB- GnRH -RRB- neurons .
22177387	0	calcium	14,21	gonadotropin-releasing_hormone	47,77	calcium	gonadotropin-releasing hormone	MESH:D002118	14714(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY homeostasis|nmod|END_ENTITY	Understanding calcium homeostasis in postnatal gonadotropin-releasing_hormone neurons using cell-specific Pericam transgenics .
2424903	0	calcium	35,42	gonadotropin-releasing_hormone	69,99	calcium	gonadotropin-releasing hormone	MESH:D002118	25194(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY Participation|nmod|channels Participation|nmod|action action|nmod|END_ENTITY	Participation of voltage-dependent calcium channels in the action of gonadotropin-releasing_hormone .
2457798	0	calcium	167,174	gonadotropin-releasing_hormone	32,62	calcium	gonadotropin-releasing hormone	MESH:D002118	2796	Chemical	Gene	channel|compound|START_ENTITY role|nmod|channel diminishes|parataxis|role diminishes|nsubj|Homologous Homologous|acl|desensitization desensitization|nmod|END_ENTITY	Homologous desensitization with gonadotropin-releasing_hormone -LRB- GnRH -RRB- also diminishes gonadotrope responsiveness to maitotoxin : a role for the GnRH_receptor-regulated calcium ion channel in mediation of cellular desensitization .
2513245	0	calcium	8,15	gonadotropin-releasing_hormone	34,64	calcium	gonadotropin-releasing hormone	MESH:D002118	2796	Chemical	Gene	Role|nmod|START_ENTITY ions|nsubj|Role ions|nmod|action action|nmod|END_ENTITY	Role of calcium ions in action of gonadotropin-releasing_hormone on gonadotropin secretion in the African catfish , Clarias gariepinus .
2547601	0	calcium	12,19	gonadotropin-releasing_hormone	23,53	calcium	gonadotropin-releasing hormone	MESH:D002118	25194(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|induction induction|amod|END_ENTITY	The role of calcium in gonadotropin-releasing_hormone induction of follicle-stimulating hormone release by the pituitary gonadotrope .
3015573	0	calcium	14,21	gonadotropin-releasing_hormone	102,132	calcium	gonadotropin-releasing hormone	MESH:D002118	2796	Chemical	Gene	required|nsubjpass|START_ENTITY required|nmod|stimulation stimulation|nmod|release release|nmod|END_ENTITY	Extracellular calcium is required for copper-amplified prostaglandin_E2 stimulation of the release of gonadotropin-releasing_hormone from median eminence explants .
3113921	0	calcium	95,102	gonadotropin-releasing_hormone	21,51	calcium	gonadotropin-releasing hormone	MESH:D002118	25194(Tax:10116)	Chemical	Gene	dependency|compound|START_ENTITY vitro|dep|dependency hypothalamus|advcl|vitro hypothalamus|nsubj|release release|nmod|END_ENTITY	Pulsatile release of gonadotropin-releasing_hormone -LRB- GnRH -RRB- from the rat hypothalamus in vitro : calcium and glucose dependency and inhibition by superactive GnRH analogs .
3293565	0	calcium	38,45	gonadotropin-releasing_hormone	66,96	calcium	gonadotropin-releasing hormone	MESH:D002118	2796	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Biphasic activation of cytosolic free calcium and LH responses by gonadotropin-releasing_hormone .
8109190	0	calcium	175,182	gonadotropin-releasing_hormone	125,155	calcium	gonadotropin-releasing hormone	MESH:D002118	25194(Tax:10116)	Chemical	Gene	ionophore|compound|START_ENTITY induced|nmod|ionophore release|acl|induced release|amod|END_ENTITY	Prolactin stimulates -LSB- 3H -RSB- dopamine release from dispersed rat tubero-infundibular dopaminergic neurons and dopamine decreases gonadotropin-releasing_hormone release induced by calcium ionophore .
8751279	0	calcium	34,41	gonadotropin-releasing_hormone	89,119	calcium	gonadotropin-releasing hormone	MESH:D002118	443529(Tax:9940)	Chemical	Gene	currents|compound|START_ENTITY estrogen|nmod|currents effect|nmod|estrogen effect|acl|END_ENTITY	A transient effect of estrogen on calcium currents and electrophysiological responses to gonadotropin-releasing_hormone in ovine gonadotropes .
9075730	0	calcium	154,161	gonadotropin-releasing_hormone	60,90	calcium	gonadotropin-releasing hormone	MESH:D002118	2796	Chemical	Gene	roles|nmod|START_ENTITY Mechanism|dep|roles Mechanism|nmod|kinase kinase|acl|activation activation|nmod|END_ENTITY	Mechanism of mitogen-activated protein kinase activation by gonadotropin-releasing_hormone in the pituitary of alphaT3-1 cell line : differential roles of calcium and protein_kinase_C .
9607773	0	calcium	12,19	gonadotropin-releasing_hormone	85,115	calcium	gonadotropin-releasing hormone	MESH:D002118	2796	Chemical	Gene	role|nmod|START_ENTITY role|nmod|regulation regulation|nmod|gene gene|amod|END_ENTITY	The role of calcium in the transcriptional and posttranscriptional regulation of the gonadotropin-releasing_hormone gene in GT1-7 cells .
1382088	0	calcium	24,31	gp330	13,18	calcium	gp330	MESH:D002118	29216(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|nsubj|END_ENTITY	Renal tubule gp330 is a calcium binding receptor for endocytic uptake of protein .
9325011	0	calcium	21,28	granulocyte-macrophage_colony-stimulating_factor	91,139	calcium	granulocyte-macrophage colony-stimulating factor	MESH:D002118	116630(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Differential role of calcium in tumour_necrosis_factor-mediated apoptosis and secretion of granulocyte-macrophage_colony-stimulating_factor in a T cell hybridoma .
1836417	0	calcium	16,23	growth-hormone-releasing-hormone	34,66	calcium	growth-hormone-releasing-hormone	MESH:D002118	29446(Tax:10116)	Chemical	Gene	intake|compound|START_ENTITY intake|nmod|END_ENTITY	-LSB- Stimulation of calcium intake by growth-hormone-releasing-hormone in GH3 cells -RSB- .
10511119	0	calcium	38,45	growth_hormone	10,24	calcium	growth hormone	MESH:D002118	2688	Chemical	Gene	treatment|nmod|START_ENTITY treatment|amod|END_ENTITY	Effect of growth_hormone treatment on calcium kinetics in patients with osteogenesis_imperfecta_type_III and IV .
1125163	0	calcium	32,39	growth_hormone	14,28	calcium	growth hormone	MESH:D002118	443329(Tax:9940)	Chemical	Gene	metabolism|compound|START_ENTITY effect|nmod|metabolism effect|nmod|END_ENTITY	The effect of growth_hormone on calcium metabolism in the sheep .
12169771	0	calcium	182,189	growth_hormone	22,36	calcium	growth hormone	MESH:D002118	81668(Tax:10116)	Chemical	Gene	concentrations|compound|START_ENTITY inhibition|nmod|concentrations coupled|nmod|inhibition coupled|nsubjpass|control control|nmod|receptors receptors|amod|secretion secretion|amod|END_ENTITY	Inhibitory control of growth_hormone secretion by somatostatin in rat pituitary GC cells : sst -LRB- 2 -RRB- but not sst -LRB- 1 -RRB- receptors are coupled to inhibition of single-cell intracellular free calcium concentrations .
15123167	0	calcium	49,56	growth_hormone	81,95	calcium	growth hormone	MESH:D002118	81668(Tax:10116)	Chemical	Gene	mobilization|compound|START_ENTITY mobilization|acl|induced induced|nmod|END_ENTITY	The phospholipase C-InsP3 pathway is involved in calcium mobilization induced by growth_hormone in hepatocytes .
16102809	0	calcium	11,18	growth_hormone	67,81	calcium	growth hormone	MESH:D002118	2688	Chemical	Gene	Effects|nmod|START_ENTITY binding|nsubj|Effects binding|nmod|structure structure|nmod|END_ENTITY	Effects of calcium binding on the structure and stability of human growth_hormone .
16153853	0	calcium	50,57	growth_hormone	102,116	calcium	growth hormone	MESH:D002118	81668(Tax:10116)	Chemical	Gene	changes|nmod|START_ENTITY homeostasis|nsubj|changes homeostasis|nmod|aging aging|nmod|END_ENTITY	Fiber type-related changes in rat skeletal muscle calcium homeostasis during aging and restoration by growth_hormone .
18602447	0	calcium	51,58	growth_hormone	81,95	calcium	growth hormone	MESH:D002118	2688	Chemical	Gene	handling|compound|START_ENTITY handling|acl|regulated regulated|nmod|END_ENTITY	Growth_hormone signaling in pancreatic beta-cells -- calcium handling regulated by growth_hormone .
1862102	0	calcium	76,83	growth_hormone	18,32	calcium	growth hormone	MESH:D002118	81668(Tax:10116)	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|Refractoriness Refractoriness|nmod|END_ENTITY	Refractoriness to growth_hormone is associated with increased intracellular calcium in rat adipocytes .
1910948	0	calcium	11,18	growth_hormone	55,69	calcium	growth hormone	MESH:D002118	2688	Chemical	Gene	antagonist|compound|START_ENTITY antagonist|nmod|secretion secretion|compound|END_ENTITY	-LSB- Effect of calcium channel antagonist -LRB- nicardipine -RRB- on growth_hormone and prolactin secretion in pituitary_adenomas -RSB- .
20392749	0	calcium	30,37	growth_hormone	144,158	calcium	growth hormone	MESH:D002118	2688	Chemical	Gene	Correlation|nmod|START_ENTITY ionized|nsubj|Correlation ionized|nmod|replacement replacement|amod|END_ENTITY	Correlation of serum-adjusted calcium with ionized calcium over a 24-h period in patients with adult_growth_hormone_deficiency before and after growth_hormone replacement .
20392749	0	calcium	51,58	growth_hormone	144,158	calcium	growth hormone	MESH:D002118	2688	Chemical	Gene	ionized|dobj|START_ENTITY ionized|nmod|replacement replacement|amod|END_ENTITY	Correlation of serum-adjusted calcium with ionized calcium over a 24-h period in patients with adult_growth_hormone_deficiency before and after growth_hormone replacement .
2103287	0	calcium	123,130	growth_hormone	31,45	calcium	growth hormone	MESH:D002118	2688	Chemical	Gene	administration|nmod|START_ENTITY -LSB-|nmod|administration -LSB-|dobj|inhibition inhibition|nmod|response response|amod|END_ENTITY	-LSB- The partial inhibition of the growth_hormone response to growth_hormone-releasing hormone after the administration of the calcium antagonist verapamil -RSB- .
2453890	0	calcium	161,168	growth_hormone	77,91	calcium	growth hormone	MESH:D002118	378781(Tax:9031)	Chemical	Gene	involvement|nmod|START_ENTITY evidence|nmod|involvement investigations|dep|evidence investigations|nmod|effects effects|nmod|END_ENTITY	Pharmacological investigations on the lipolytic and antilipolytic effects of growth_hormone -LRB- GH -RRB- in chicken adipose tissue in vitro : evidence for involvement of calcium and polyamines .
2507391	0	calcium	26,33	growth_hormone	37,51	calcium	growth hormone	MESH:D002118	2688	Chemical	Gene	participation|nmod|START_ENTITY participation|nmod|release release|amod|END_ENTITY	Possible participation of calcium in growth_hormone release and in thyrotropin-releasing_hormone and human pancreatic growth_hormone-releasing factor synergy in a primary culture of chicken pituitary cells .
2853992	0	calcium	69,76	growth_hormone	11,25	calcium	growth hormone	MESH:D002118	2688	Chemical	Gene	channel|compound|START_ENTITY effects|nmod|channel END_ENTITY|dep|effects	Release of growth_hormone from purified somatotrophs : effects of the calcium channel antagonists diltiazem and nifedipine on release induced by growth_hormone-releasing factor .
2883000	0	calcium	108,115	growth_hormone	30,44	calcium	growth hormone	MESH:D002118	81668(Tax:10116)	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|stimulation stimulation|nmod|levels levels|amod|END_ENTITY	Glucocorticoid stimulation of growth_hormone messenger ribonucleic acid levels in GH3 cells is inhibited by calcium but not by somatostatin .
3087782	0	calcium	25,32	growth_hormone	124,138	calcium	growth hormone	MESH:D002118	2688	Chemical	Gene	concentrations|compound|START_ENTITY measure|dobj|concentrations measure|nmod|secretion secretion|nmod|END_ENTITY	Use of quin_2 to measure calcium concentrations in ovine anterior pituitary cells and the effects of quin_2 on secretion of growth_hormone and prolactin .
744925	0	calcium	137,144	growth_hormone	10,24	calcium	growth hormone	MESH:D002118	81668(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of growth_hormone on the metabolism of 25-hydroxycholecalciferol in hypophysectomized rats on a diet without vitamin_D and low in calcium .
8013937	0	calcium	57,64	growth_hormone	11,25	calcium	growth hormone	MESH:D002118	2688	Chemical	Gene	homeostasis|compound|START_ENTITY Effects|nmod|homeostasis Effects|nmod|treatment treatment|amod|END_ENTITY	Effects of growth_hormone treatment for short_stature on calcium homeostasis , bone mineralisation , and body composition .
8037738	0	calcium	46,53	growth_hormone	111,125	calcium	growth hormone	MESH:D002118	2688	Chemical	Gene	START_ENTITY|dep|mechanism mechanism|nmod|transmembrane transmembrane|amod|END_ENTITY	Human growth_hormone increases cytosolic free calcium in cultured human IM-9 lymphocytes : a novel mechanism of growth_hormone transmembrane signalling .
8037738	0	calcium	46,53	growth_hormone	6,20	calcium	growth hormone	MESH:D002118	2688	Chemical	Gene	increases|dobj|START_ENTITY increases|nsubj|END_ENTITY	Human growth_hormone increases cytosolic free calcium in cultured human IM-9 lymphocytes : a novel mechanism of growth_hormone transmembrane signalling .
8100619	0	calcium	110,117	growth_hormone	35,49	calcium	growth hormone	MESH:D002118	81668(Tax:10116)	Chemical	Gene	influx|compound|START_ENTITY dependent|nmod|influx dependent|nsubj|hypersecretion hypersecretion|nmod|cells cells|amod|END_ENTITY	Postsomatostatin hypersecretion of growth_hormone from perifused rat anterior pituitary cells is dependent on calcium influx .
8187303	0	calcium	76,83	growth_hormone	14,28	calcium	growth hormone	MESH:D002118	2688	Chemical	Gene	metabolism|compound|START_ENTITY effect|nmod|metabolism effect|nmod|therapy therapy|amod|END_ENTITY	The effect of growth_hormone replacement therapy in hypopituitary adults on calcium and bone metabolism .
8413934	0	calcium	29,36	growth_hormone	49,63	calcium	growth hormone	MESH:D002118	2688	Chemical	Gene	currents|compound|START_ENTITY modulation|nmod|currents modulation|nmod|cells cells|amod|END_ENTITY	Glucocorticoid modulation of calcium currents in growth_hormone 3 cells .
9495517	0	calcium	11,18	growth_hormone	90,104	calcium	growth hormone	MESH:D002118	2688	Chemical	Gene	absorption|compound|START_ENTITY absorption|nmod|deficiency deficiency|compound|END_ENTITY	Intestinal calcium absorption and bone metabolism in young adult men with childhood-onset growth_hormone deficiency .
3138899	0	calcium	84,91	growth_hormone-releasing_factor	15,46	calcium	growth hormone-releasing factor	MESH:D002118	29446(Tax:10116)	Chemical	Gene	Actions|nmod|START_ENTITY Actions|nmod|END_ENTITY	Actions of rat growth_hormone-releasing_factor and norepinephrine on cytosolic free calcium and inositol_trisphosphate in rat C-cells .
10535712	0	calcium	14,21	growth_hormone-releasing_hormone	45,77	calcium	growth hormone-releasing hormone	MESH:D002118	29446(Tax:10116)	Chemical	Gene	stores|compound|START_ENTITY involved|nsubjpass|stores involved|nmod|transduction transduction|amod|END_ENTITY	Intracellular calcium stores are involved in growth_hormone-releasing_hormone signal transduction in rat somatotrophs .
1679376	0	calcium	69,76	growth_hormone-releasing_hormone	91,123	calcium	growth hormone-releasing hormone	MESH:D002118	281191(Tax:9913)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Calcium homeostasis in bovine somatotrophs : calcium oscillations and calcium regulation by growth_hormone-releasing_hormone and somatostatin .
8806608	0	calcium	120,127	grp78	53,58	calcium	grp78	MESH:D002118	3309	Chemical	Gene	role|nmod|START_ENTITY induction|dep|role induction|nmod|END_ENTITY	Selective induction of the glucose-regulated protein grp78 in human monocytes by bacterial extracts -LRB- OM-85 -RRB- : a role for calcium as second messenger .
23184735	0	calcium	4,11	gsk3b	52,57	calcium	gsk3b	MESH:D002118	2932	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	How calcium inhibits the magnesium-dependent kinase gsk3b : a molecular simulation study .
9425045	0	calcium	102,109	guanylate_cyclase-activating_protein_1	46,84	calcium	guanylate cyclase-activating protein 1	MESH:D002118	2980	Chemical	Gene	function|nmod|START_ENTITY END_ENTITY|nmod|function	Changes in biological activity and folding of guanylate_cyclase-activating_protein_1 as a function of calcium .
22383530	0	calcium	230,237	guanylyl_cyclase-activating_protein_1	124,161	calcium	guanylyl cyclase-activating protein 1	MESH:D002118	2978	Chemical	Gene	sensitivity|compound|START_ENTITY sensitivity|amod|END_ENTITY	Calcium-myristoyl Tug is a new mechanism for intramolecular tuning of calcium sensitivity and target enzyme interaction for guanylyl_cyclase-activating_protein_1 : dynamic connection between N-fatty_acyl group and EF-hand controls calcium sensitivity .
14706284	0	calcium	59,66	hTRPC1	11,17	calcium	hTRPC1	MESH:D002118	7220	Chemical	Gene	entry|compound|START_ENTITY role|nmod|entry role|nmod|END_ENTITY	A role for hTRPC1 and lipid_raft_domains in store-mediated calcium entry in human platelets .
15769486	0	calcium	38,45	histone_H1	10,20	calcium	histone H1	MESH:D002118	3005	Chemical	Gene	levels|compound|START_ENTITY END_ENTITY|nmod|levels	Effect of histone_H1 on the cytosolic calcium levels in human breast_cancer MCF 7 cells .
10444449	0	calcium	11,18	iNOS	62,66	calcium	iNOS	MESH:D002118	24599(Tax:10116)	Chemical	Gene	antagonists|compound|START_ENTITY Effects|nmod|antagonists END_ENTITY|nsubj|Effects	Effects of calcium channel antagonists on LPS-induced hepatic iNOS expression .
22549782	0	calcium	32,39	inducible_nitric-oxide_synthase	66,97	calcium	inducible nitric-oxide synthase	MESH:D002118	4843	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	Increased resting intracellular calcium modulates NF-kB-dependent inducible_nitric-oxide_synthase gene expression in dystrophic_mdx_skeletal_myotubes .
10754630	0	calcium	129,136	inducible_nitric_oxide_synthase	74,105	calcium	inducible nitric oxide synthase	MESH:D002118	18126(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY expression|dep|role expression|nmod|END_ENTITY	Volatile anesthetics differentially affect immunostimulated expression of inducible_nitric_oxide_synthase : role of intracellular calcium .
11171114	0	calcium	57,64	inducible_nitric_oxide_synthase	86,117	calcium	inducible nitric oxide synthase	MESH:D002118	4843	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Bi-directional effects of the elevation of intracellular calcium on the expression of inducible_nitric_oxide_synthase in J774 macrophages exposed to low and to high concentrations of endotoxin .
1064022	0	calcium	31,38	insulin	11,18	calcium	insulin	MESH:D002118	3630	Chemical	Gene	increase|dobj|START_ENTITY Ability|acl|increase Ability|nmod|END_ENTITY	Ability of insulin to increase calcium binding by adipocyte plasma membranes .
1117893	1	calcium	96,103	insulin	107,114	calcium	insulin	MESH:D002118	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|release release|compound|END_ENTITY	Effect of serum calcium on insulin release .
11408399	0	calcium	45,52	insulin	10,17	calcium	insulin	MESH:D002118	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of insulin and angiotensin_II on cell calcium in human skin fibroblasts .
12745190	0	calcium	13,20	insulin	55,62	calcium	insulin	MESH:D002118	3630	Chemical	Gene	intoxication|compound|START_ENTITY intoxication|nmod|infusion infusion|compound|END_ENTITY	Treatment of calcium channel blocker intoxication with insulin infusion : case report and literature review .
15298353	0	calcium	49,56	insulin	23,30	calcium	insulin	MESH:D002118	3630	Chemical	Gene	current|compound|START_ENTITY effects|nmod|current effects|nmod|END_ENTITY	Paradoxical effects of insulin on cardiac L-type calcium current and on contraction at physiological temperature .
15617878	0	calcium	102,109	insulin	62,69	calcium	insulin	MESH:D002118	3630	Chemical	Gene	antagonist|compound|START_ENTITY acting|nmod|antagonist mediate|advcl|acting mediate|dobj|impact impact|nmod|grains grains|nmod|sensitivity sensitivity|compound|END_ENTITY	Magnesium may mediate the favorable impact of whole grains on insulin sensitivity by acting as a mild calcium antagonist .
16317050	0	calcium	82,89	insulin	18,25	calcium	insulin	MESH:D002118	3630	Chemical	Gene	sources|compound|START_ENTITY pool|nmod|sources pool|nsubj|Regulation Regulation|nmod|populations populations|compound|END_ENTITY	Regulation of two insulin granule populations within the reserve pool by distinct calcium sources .
16861328	0	calcium	22,29	insulin	52,59	calcium	insulin	MESH:D002118	3630	Chemical	Gene	intake|compound|START_ENTITY intake|acl|relation relation|nmod|sensitivity sensitivity|compound|END_ENTITY	Dairy , magnesium , and calcium intake in relation to insulin sensitivity : approaches to modeling a dose-dependent association .
16865295	0	calcium	66,73	insulin	21,28	calcium	insulin	MESH:D002118	3630	Chemical	Gene	response|compound|START_ENTITY END_ENTITY|nmod|response	Inhibitory effect of insulin on vasopressin-induced intracellular calcium response is blunted in hyperinsulinemic hypertensive patients : role of membrane fatty_acid composition .
16977264	0	calcium	18,25	insulin	100,107	calcium	insulin	MESH:D002118	3630	Chemical	Gene	Effect|nmod|START_ENTITY intake|nsubj|Effect intake|dobj|patients patients|nmod|initiation initiation|nmod|therapy therapy|compound|END_ENTITY	Effect of dietary calcium intake on weight_gain in type 2 diabetic patients following initiation of insulin therapy .
173837	0	calcium	101,108	insulin	69,76	calcium	insulin	MESH:D002118	3630	Chemical	Gene	fluxes|nmod|START_ENTITY mechanisms|dep|fluxes mechanisms|nmod|action action|nmod|chloromercuribenzene-p-sulphonic_acid chloromercuribenzene-p-sulphonic_acid|nmod|secretagogue secretagogue|compound|END_ENTITY	The mechanisms of action of chloromercuribenzene-p-sulphonic_acid as insulin secretagogue : fluxes of calcium , sodium and rubidium in islets exposed to mercurial and a membrane-active antagonist .
17611089	0	calcium	16,23	insulin	95,102	calcium	insulin	MESH:D002118	100009181(Tax:9986)	Chemical	Gene	ions|compound|START_ENTITY addition|nmod|ions enhances|nsubj|addition enhances|dobj|bioavailability bioavailability|nmod|END_ENTITY	The addition of calcium ions to starch/Carbopol mixtures enhances the nasal bioavailability of insulin .
18191448	0	calcium	24,31	insulin	65,72	calcium	insulin	MESH:D002118	3630	Chemical	Gene	Impact|nmod|START_ENTITY Impact|nmod|secretion secretion|compound|END_ENTITY	Impact of mitochondrial calcium on the coupling of metabolism to insulin secretion in the pancreatic beta-cell .
18583466	0	calcium	125,132	insulin	80,87	calcium	insulin	MESH:D002118	3630	Chemical	Gene	mobilization|compound|START_ENTITY acting|nmod|mobilization secretion|advcl|acting secretion|nsubj|mutation mutation|nmod|associates associates|nmod|END_ENTITY	Loss-of-function mutation of the GPR40 gene associates with abnormal stimulated insulin secretion by acting on intracellular calcium mobilization .
20134036	0	calcium	12,19	insulin	139,146	calcium	insulin	MESH:D002118	3630	Chemical	Gene	Kinetics|nmod|START_ENTITY ion|nsubj|Kinetics ion|nmod|END_ENTITY	Kinetics of calcium ion concentration accompanying transduction of signals into neutrophils from diabetic patients and its modification by insulin .
2175805	0	calcium	86,93	insulin	37,44	calcium	insulin	MESH:D002118	3630	Chemical	Gene	uptake|compound|START_ENTITY role|nmod|uptake effects|dep|role effects|nmod|maitotoxin maitotoxin|nmod|release release|compound|END_ENTITY	Stimulatory effects of maitotoxin on insulin release in insulinoma HIT cells : role of calcium uptake and phosphoinositide breakdown .
2183445	0	calcium	86,93	insulin	27,34	calcium	insulin	MESH:D002118	3630	Chemical	Gene	concentration|compound|START_ENTITY effect|nmod|concentration inhibition|dep|effect inhibition|nmod|secretion secretion|compound|END_ENTITY	Cyclosporine inhibition of insulin secretion : effect of tolbutamide and extracellular calcium concentration .
22829522	0	calcium	104,111	insulin	13,20	calcium	insulin	MESH:D002118	3630	Chemical	Gene	relationships|nmod|START_ENTITY Fatty_liver|dep|relationships Fatty_liver|appos|resistance resistance|compound|END_ENTITY	Fatty_liver , insulin resistance , and features of metabolic_syndrome : relationships with coronary artery calcium in 10,153 people .
23815372	0	calcium	100,107	insulin	62,69	calcium	insulin	MESH:D002118	3630	Chemical	Gene	dynamics|compound|START_ENTITY due|nmod|dynamics due|nsubj|secretion secretion|compound|END_ENTITY	Chronic_glucolipotoxic_conditions in pancreatic_islets impair insulin secretion due to dysregulated calcium dynamics , glucose responsiveness and mitochondrial activity .
2440732	0	calcium	26,33	insulin	11,18	calcium	insulin	MESH:D002118	3630	Chemical	Gene	current|compound|START_ENTITY END_ENTITY|nmod|current	-LSB- Effect of insulin on the calcium current of the frog myocardium -RSB- .
2986614	0	calcium	8,15	insulin	29,36	calcium	insulin	MESH:D002118	3630	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Role of calcium in defective insulin secretion from human and transplantable rat islet cell tumours .
2999178	0	calcium	56,63	insulin	15,22	calcium	insulin	MESH:D002118	3630	Chemical	Gene	infusion|compound|START_ENTITY secretion|nmod|infusion secretion|nsubj|Stimulation Stimulation|nmod|END_ENTITY	Stimulation of insulin secretion by a rapid intravenous calcium infusion in patients with beta-cell_neoplasms of the pancreas .
3066562	2	calcium	58,65	insulin	105,112	calcium	insulin	MESH:D002118	3630	Chemical	Gene	antagonist|compound|START_ENTITY Effects|nmod|antagonist Effects|nmod|release release|compound|END_ENTITY	Effects of a calcium antagonist -LRB- verapamil -RRB- on the biphasic insulin release in vivo .
3081574	0	calcium	28,35	insulin	58,65	calcium	insulin	MESH:D002118	3630	Chemical	Gene	concentrations|compound|START_ENTITY Calcium|dobj|concentrations Calcium|nmod|secretion secretion|compound|END_ENTITY	Calcium dependency and free calcium concentrations during insulin secretion in a hamster beta cell line .
3143744	0	calcium	32,39	insulin	68,75	calcium	insulin	MESH:D002118	3630	Chemical	Gene	concentrations|compound|START_ENTITY concentrations|acl|mediating mediating|dobj|resistance resistance|compound|END_ENTITY	Possible role of cytosolic free calcium concentrations in mediating insulin resistance of obesity and hyperinsulinemia .
3319861	0	calcium	99,106	insulin	10,17	calcium	insulin	MESH:D002118	3630	Chemical	Gene	antagonism|compound|START_ENTITY increased|nmod|antagonism increased|nsubj|secretion secretion|compound|END_ENTITY	Unchanged insulin secretion and glucose tolerance but increased insulin clearance during long-term calcium antagonism with felodipine in essential hypertension .
3319861	0	calcium	99,106	insulin	64,71	calcium	insulin	MESH:D002118	3630	Chemical	Gene	antagonism|compound|START_ENTITY increased|nmod|antagonism increased|dobj|clearance clearance|compound|END_ENTITY	Unchanged insulin secretion and glucose tolerance but increased insulin clearance during long-term calcium antagonism with felodipine in essential hypertension .
365654	0	calcium	11,18	insulin	82,89	calcium	insulin	MESH:D002118	3630	Chemical	Gene	lanthanum|compound|START_ENTITY Effects|nmod|lanthanum Effects|nmod|modification modification|nmod|release release|compound|END_ENTITY	Effects of calcium , lanthanum , and bicarbonate ion on epinephrine modification of insulin release in vitro .
3899141	0	calcium	31,38	insulin	63,70	calcium	insulin	MESH:D002118	3630	Chemical	Gene	Effect|nmod|START_ENTITY load|nsubj|Effect load|nmod|secretion secretion|compound|END_ENTITY	Effect of oral and intravenous calcium load on glucose-induced insulin secretion in obese children .
407113	0	calcium	94,101	insulin	85,92	calcium	insulin	MESH:D002118	396145(Tax:9031)	Chemical	Gene	A_23187|dep|START_ENTITY A_23187|compound|END_ENTITY	Regulation of glycogen synthase interconversion in cultured muscle cells : actions of insulin , calcium , ionophore A_23187 and cytochalasin B .
4919944	0	calcium	21,28	insulin	84,91	calcium	insulin	MESH:D002118	3630	Chemical	Gene	START_ENTITY|nmod|coupling coupling|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- A possible role for calcium in the stimulus-secretion coupling for glucose-induced insulin secretion -RSB- .
6315010	0	calcium	87,94	insulin	25,32	calcium	insulin	MESH:D002118	3630	Chemical	Gene	factor-I|nmod|START_ENTITY factor-I|nsubj|modulation modulation|nmod|growth growth|compound|END_ENTITY	Reciprocal modulation of insulin and insulin-like growth factor-I receptor affinity by calcium .
7010607	0	calcium	110,117	insulin	57,64	calcium	insulin	MESH:D002118	280829(Tax:9913)	Chemical	Gene	hexamer|dep|START_ENTITY studies|dep|hexamer studies|nmod|END_ENTITY	Cadmium-113 nuclear magnetic resonance studies of bovine insulin : two-zinc insulin hexamer specifically binds calcium .
7010607	0	calcium	110,117	insulin	75,82	calcium	insulin	MESH:D002118	280829(Tax:9913)	Chemical	Gene	hexamer|dep|START_ENTITY hexamer|compound|END_ENTITY	Cadmium-113 nuclear magnetic resonance studies of bovine insulin : two-zinc insulin hexamer specifically binds calcium .
7018517	1	calcium	72,79	insulin	100,107	calcium	insulin	MESH:D002118	3630	Chemical	Gene	infusion|nmod|START_ENTITY Effects|nmod|infusion Effects|nmod|-RSB- -RSB-|compound|END_ENTITY	I. Effects of an infusion of calcium on plasma levels of insulin and glucagon -RSB- .
747892	0	calcium	28,35	insulin	92,99	calcium	insulin	MESH:D002118	3630	Chemical	Gene	elevation|compound|START_ENTITY ionized|dobj|elevation ionized|nmod|inhibition inhibition|nmod|release release|compound|END_ENTITY	The effect of serum ionized calcium elevation on somatostatin inhibition of glucose-induced insulin release in humans .
7503739	0	calcium	78,85	insulin	48,55	calcium	insulin	MESH:D002118	3630	Chemical	Gene	release|compound|START_ENTITY inducing|dobj|release stimulates|advcl|inducing stimulates|dobj|secretion secretion|compound|END_ENTITY	Nitric_oxide -LRB- nitrogen_monoxide , NO -RRB- stimulates insulin secretion by inducing calcium release from mitochondria .
8931646	0	calcium	43,50	insulin	18,25	calcium	insulin	MESH:D002118	3630	Chemical	Gene	concentrations|compound|START_ENTITY END_ENTITY|nmod|concentrations	In vivo effect of insulin on intracellular calcium concentrations : relation to insulin resistance .
8931646	0	calcium	43,50	insulin	79,86	calcium	insulin	MESH:D002118	3630	Chemical	Gene	concentrations|compound|START_ENTITY insulin|nmod|concentrations effect|nmod|insulin relation|nmod|effect relation|nmod|resistance resistance|compound|END_ENTITY	In vivo effect of insulin on intracellular calcium concentrations : relation to insulin resistance .
9231655	0	calcium	53,60	insulin	25,32	calcium	insulin	MESH:D002118	3630	Chemical	Gene	influx|compound|START_ENTITY distal|nmod|influx distal|nsubj|requirement requirement|nmod|secretion secretion|compound|END_ENTITY	Energetic requirement of insulin secretion distal to calcium influx .
9623638	0	calcium	41,48	insulin	16,23	calcium	insulin	MESH:D002118	3630	Chemical	Gene	bolus|nmod|START_ENTITY bolus|nsubj|Effects Effects|nmod|END_ENTITY	Effects of i.v. insulin bolus on urinary calcium and oxalate excretion in healthy subjects .
9797194	0	calcium	43,50	insulin	21,28	calcium	insulin	MESH:D002118	3630	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Modulatory effect of insulin on release of calcium from human fibroblasts by angiotensin_II .
8477645	0	calcium	14,21	insulin-like_growth_factor-I	32,60	calcium	insulin-like growth factor-I	MESH:D002118	24482(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|levels levels|amod|END_ENTITY	Intracellular calcium regulates insulin-like_growth_factor-I messenger ribonucleic acid levels .
15161756	0	calcium	88,95	insulin_receptor_substrate_1	26,54	calcium	insulin receptor substrate 1	MESH:D002118	16367(Tax:10090)	Chemical	Gene	signaling|compound|START_ENTITY linked|nmod|signaling linked|nsubjpass|defect defect|nmod|mice mice|amod|END_ENTITY	Islet secretory defect in insulin_receptor_substrate_1 null mice is linked with reduced calcium signaling and expression of sarco -LRB- endo -RRB- plasmic_reticulum_Ca2 + - ATPase -LRB- SERCA -RRB- -2 b_and _ -3 .
11936187	0	calcium	21,28	interferon-gamma	42,58	calcium	interferon-gamma	MESH:D002118	3458	Chemical	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Fibronectin promotes calcium signaling by interferon-gamma in human neutrophils via G-protein and sphingosine kinase-dependent mechanisms .
1899359	0	calcium	65,72	interferon-gamma	13,29	calcium	interferon-gamma	MESH:D002118	3458	Chemical	Gene	dependent|advmod|START_ENTITY dependent|nsubj|Induction Induction|nmod|END_ENTITY	Induction of interferon-gamma by cord blood mononuclear cells is calcium dependent .
19919129	0	calcium	65,72	interferon-gamma	19,35	calcium	interferon-gamma	MESH:D002118	3458	Chemical	Gene	release|compound|START_ENTITY modulation|nmod|release production|nmod|modulation production|amod|END_ENTITY	FIP-fve stimulates interferon-gamma production via modulation of calcium release and PKC-alpha activation .
2955785	0	calcium	34,41	interferon-gamma	56,72	calcium	interferon-gamma	MESH:D002118	3458	Chemical	Gene	modulation|compound|START_ENTITY modulation|nmod|END_ENTITY	Potential mechanisms of cytosolic calcium modulation in interferon-gamma treated U937 cells .
1714774	0	calcium	103,110	interleukin-1	12,25	calcium	interleukin-1	MESH:D002118	3552	Chemical	Gene	role|nmod|START_ENTITY stimulates|parataxis|role stimulates|nsubj|END_ENTITY	Recombinant interleukin-1 -LRB- IL-1 -RRB- stimulates prostaglandin_E2 production by osteoblastic cells : role of calcium , calmodulin , and cAMP .
1715762	0	calcium	8,15	interleukin-1	19,32	calcium	interleukin-1	MESH:D002118	3552	Chemical	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Role of calcium on interleukin-1 production by monocytes : its relevance during T cell proliferation .
2165034	0	calcium	79,86	interleukin-1	120,133	calcium	interleukin-1	MESH:D002118	111343(Tax:10090)	Chemical	Gene	ions|compound|START_ENTITY ions|nmod|stimulation stimulation|nmod|release release|amod|END_ENTITY	Possible involvement of adenosine_3 ' :5 ' - cyclic_monophosphate and extracellular calcium ions in histamine stimulation of interleukin-1 release from macrophage-like P388D1 cells .
2444222	0	calcium	27,34	interleukin-1	73,86	calcium	interleukin-1	MESH:D002118	3552	Chemical	Gene	role|nmod|START_ENTITY Lack|nmod|role Lack|nmod|induction induction|nmod|END_ENTITY	Lack of a central role for calcium in the induction and release of human interleukin-1 .
3264990	0	calcium	40,47	interleukin-1	5,18	calcium	interleukin-1	MESH:D002118	3552	Chemical	Gene	affect|dobj|START_ENTITY affect|nsubj|END_ENTITY	Does interleukin-1 affect intracellular calcium in osteoblast-like cells -LRB- UMR-106 -RRB- ?
8393508	0	calcium	49,56	interleukin-1	11,24	calcium	interleukin-1	MESH:D002118	3552	Chemical	Gene	fluxes|compound|START_ENTITY induce|dobj|fluxes END_ENTITY|xcomp|induce	Failure of interleukin-1 to induce intracellular calcium fluxes in K562 cells .
14764428	0	calcium	14,21	interleukin-13	35,49	calcium	interleukin-13	MESH:D002118	3596	Chemical	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Modulation of calcium signaling by interleukin-13 in human airway_smooth_muscle : role of CD38/cyclic adenosine_diphosphate ribose pathway .
1319327	0	calcium	96,103	interleukin-1_alpha	20,39	calcium	interleukin-1 alpha	MESH:D002118	24493(Tax:10116)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition by human interleukin-1_alpha of parathyroid hormone-related peptide effects on renal calcium and phosphorus metabolism in the rat .
10479156	0	calcium	80,87	interleukin-1beta	23,40	calcium	interleukin-1beta	MESH:D002118	3553	Chemical	Gene	START_ENTITY|nsubj|expression expression|amod|END_ENTITY	Amphotericin_B-induced interleukin-1beta expression in human monocytic cells is calcium and calmodulin dependent .
15634940	0	calcium	39,46	interleukin-4	14,27	calcium	interleukin-4	MESH:D002118	280824(Tax:9913)	Chemical	Gene	effects|nmod|START_ENTITY effects|compound|END_ENTITY	Mechanisms of interleukin-4 effects on calcium signaling in airway smooth muscle cells .
9405450	0	calcium	123,130	interleukin-4	14,27	calcium	interleukin-4	MESH:D002118	287287(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY kinase|nmod|channels involves|ccomp|kinase involves|nsubj|expression expression|compound|END_ENTITY	HgCl2-induced interleukin-4 gene expression in T cells involves a protein kinase C-dependent calcium influx through L-type calcium channels .
9405450	0	calcium	93,100	interleukin-4	14,27	calcium	interleukin-4	MESH:D002118	287287(Tax:10116)	Chemical	Gene	influx|compound|START_ENTITY kinase|dobj|influx involves|ccomp|kinase involves|nsubj|expression expression|compound|END_ENTITY	HgCl2-induced interleukin-4 gene expression in T cells involves a protein kinase C-dependent calcium influx through L-type calcium channels .
9041054	0	calcium	84,91	interleukin-6	14,27	calcium	interleukin-6	MESH:D002118	3569	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|secretion secretion|amod|END_ENTITY	Regulation of interleukin-6 secretion from mononuclear blood cells by extracellular calcium .
11404389	0	calcium	34,41	interleukin-8	60,73	calcium	interleukin-8	MESH:D002118	3576	Chemical	Gene	changes|compound|START_ENTITY substance_P|nmod|changes effects|nmod|substance_P evoked|nsubj|effects evoked|advcl|END_ENTITY	Priming effects of substance_P on calcium changes evoked by interleukin-8 in human neutrophils .
11591115	0	calcium	23,30	interleukin-8	99,112	calcium	interleukin-8	MESH:D002118	3576	Chemical	Gene	Roles|nmod|START_ENTITY Calmette-Gu|nsubj|Roles Calmette-Gu|dobj|secretion secretion|nmod|END_ENTITY	Roles of intracellular calcium and NF-kappaB in the Bacillus Calmette-Gu rin-induced secretion of interleukin-8 from human monocytes .
15071361	0	calcium	44,51	interleukin-8	109,122	calcium	interleukin-8	MESH:D002118	3576	Chemical	Gene	antagonist|compound|START_ENTITY Azelnidipine|appos|antagonist inhibits|nsubj|Azelnidipine inhibits|dobj|expression expression|amod|END_ENTITY	Azelnidipine , a newly developed long-acting calcium antagonist , inhibits tumor_necrosis_factor-alpha-induced interleukin-8 expression in endothelial cells through its anti-oxidative properties .
15286717	0	calcium	39,46	interleukin-8	70,83	calcium	interleukin-8	MESH:D002118	3576	Chemical	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Inhibitory effects of cyclosporin_A on calcium mobilization-dependent interleukin-8 expression and invasive potential of human glioblastoma U251MG cells .
7510691	0	calcium	112,119	interleukin-8	4,17	calcium	interleukin-8	MESH:D002118	3576	Chemical	Gene	mobilization|compound|START_ENTITY accompanied|nmod|mobilization FK506-sensitive|acl|accompanied targets|nmod|FK506-sensitive targets|nsubj|AP-1 AP-1|amod|END_ENTITY	The interleukin-8 AP-1 and kappa B-like sites are genetic end targets of FK506-sensitive pathway accompanied by calcium mobilization .
8458381	0	calcium	89,96	interleukin-8	55,68	calcium	interleukin-8	MESH:D002118	3576	Chemical	Gene	ionophore|compound|START_ENTITY produce|nmod|ionophore produce|dobj|END_ENTITY	Human peripheral blood eosinophils produce and release interleukin-8 on stimulation with calcium ionophore .
3033074	0	calcium	68,75	interleukin_1_beta	18,36	calcium	interleukin 1 beta	MESH:D002118	3553	Chemical	Gene	effect|nmod|START_ENTITY has|dobj|effect has|nsubj|END_ENTITY	Human recombinant interleukin_1_beta has no effect on intracellular calcium or on functional responses of human neutrophils .
10816578	0	calcium	35,42	involucrin	66,76	calcium	involucrin	MESH:D002118	3713	Chemical	Gene	region|compound|START_ENTITY Requirement|nmod|region Requirement|nmod|promoter promoter|compound|END_ENTITY	Requirement of an AP-1 site in the calcium response region of the involucrin promoter .
9159190	0	calcium	44,51	involucrin	14,24	calcium	involucrin	MESH:D002118	3713	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Regulation of involucrin gene expression by calcium in normal human keratinocytes .
4017636	0	calcium	8,15	lacrimal_gland_protein	46,68	calcium	lacrimal gland protein	MESH:D002118	292801(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|secretion secretion|compound|END_ENTITY	Role of calcium in cholinergic stimulation of lacrimal_gland_protein secretion .
21237226	0	calcium	14,21	legumain	59,67	calcium	legumain	MESH:D002118	5641	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Nucleoplasmic calcium regulates cell proliferation through legumain .
19583244	0	calcium	12,19	low-density_lipoprotein_receptor	50,82	calcium	low-density lipoprotein receptor	MESH:D002118	3949	Chemical	Gene	role|nmod|START_ENTITY release|nsubj|role release|nmod|END_ENTITY	The role of calcium in lipoprotein release by the low-density_lipoprotein_receptor .
6324760	0	calcium	12,19	luteinizing_hormone-releasing_hormone	23,60	calcium	luteinizing hormone-releasing hormone	MESH:D002118	25194(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|agonist agonist|amod|END_ENTITY	The role of calcium in luteinizing_hormone-releasing_hormone agonist -LRB- ICI_118630 -RRB- - stimulated steroidogenesis in rat Leydig cells .
6271738	0	calcium	11,18	lysozyme	22,30	calcium	lysozyme	MESH:D002118	4069	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of calcium to lysozyme and its derivatives .
12814357	0	calcium	14,21	mGluR1	45,51	calcium	mGluR1	MESH:D002118	14799(Tax:10090)	Chemical	Gene	release|compound|START_ENTITY release|acl|resulting resulting|nmod|activation activation|amod|END_ENTITY	Intracellular calcium release resulting from mGluR1 receptor activation modulates GABAA currents in wide-field retinal amacrine cells : a study with caffeine .
19657020	0	calcium	113,120	mGluR1	28,34	calcium	mGluR1	MESH:D002118	14799(Tax:10090)	Chemical	Gene	parallel|dobj|START_ENTITY contributes|xcomp|parallel contributes|nsubj|coupling coupling|nmod|channels channels|amod|END_ENTITY	Functional coupling between mGluR1 and Cav3 .1 T-type calcium channels contributes to parallel fiber-induced fast calcium signaling within Purkinje cell dendritic spines .
19657020	0	calcium	53,60	mGluR1	28,34	calcium	mGluR1	MESH:D002118	14799(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Functional coupling between mGluR1 and Cav3 .1 T-type calcium channels contributes to parallel fiber-induced fast calcium signaling within Purkinje cell dendritic spines .
9116662	0	calcium	38,45	mGluR1	0,6	calcium	mGluR1	MESH:D002118	14799(Tax:10090)	Chemical	Gene	signalling|nmod:npmod|START_ENTITY study|dobj|signalling tool|acl|study mice|nmod|tool mice|amod|END_ENTITY	mGluR1 mutant mice as a tool to study calcium signalling and multiple innervation in the cerebellum .
9326275	0	calcium	51,58	mGluR5	36,42	calcium	mGluR5	MESH:D002118	14805(Tax:10090)	Chemical	Gene	oscillations|compound|START_ENTITY induces|dobj|oscillations induces|nsubj|END_ENTITY	The metabotropic glutamate receptor mGluR5 induces calcium oscillations in cultured astrocytes via protein kinase C phosphorylation .
21161195	0	calcium	10,17	matrix-Gla_protein	50,68	calcium	matrix-Gla protein	MESH:D002118	25333(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|cells cells|amod|END_ENTITY	Effect of calcium and the calcimimetic AMG_641 on matrix-Gla_protein in vascular smooth muscle cells .
17540003	0	calcium	34,41	matrix_metalloproteinase-9	140,166	calcium	matrix metalloproteinase-9	MESH:D002118	17395(Tax:10090)	Chemical	Gene	activity|compound|START_ENTITY activity|acl|induce induce|dobj|expression expression|amod|END_ENTITY	Acidic extracellular pH increases calcium influx-triggered phospholipase D activity along with acidic sphingomyelinase activation to induce matrix_metalloproteinase-9 expression in mouse metastatic_melanoma .
20590612	0	calcium	121,128	matrix_metalloproteinase-9	73,99	calcium	matrix metalloproteinase-9	MESH:D002118	4318	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Metformin blocks migration and invasion of tumour cells by inhibition of matrix_metalloproteinase-9 activation through a calcium and protein kinase Calpha-dependent pathway : phorbol-12-myristate-13-acetate-induced / extracellular_signal-regulated_kinase / activator_protein-1 .
17976080	0	calcium	59,66	megalin	8,15	calcium	megalin	MESH:D002118	4036	Chemical	Gene	homeostasis|compound|START_ENTITY Role|nmod|homeostasis Role|nmod|END_ENTITY	Role of megalin , a proximal tubular endocytic receptor , in calcium and phosphate homeostasis .
1279340	0	calcium	84,91	melittin	10,18	calcium	melittin	MESH:D002118	406130(Tax:7460)	Chemical	Gene	release|compound|START_ENTITY reducing|nmod|release toxin|acl|reducing toxin|nsubj|END_ENTITY	Bee venom melittin is a potent toxin for reducing the threshold for calcium-induced calcium release in human and equine skeletal muscle .
6652077	0	calcium	93,100	melittin	22,30	calcium	melittin	MESH:D002118	406130(Tax:7460)	Chemical	Gene	changes|nmod|START_ENTITY changes|nmod|END_ENTITY	Structural changes in melittin and calmodulin upon complex formation and their modulation by calcium .
26686727	0	calcium	70,77	milk	65,69	calcium	milk	MESH:D002118	100532204	Chemical	Gene	content|compound|START_ENTITY content|compound|END_ENTITY	Dietary cation-anion difference and day length have an effect on milk calcium content and bone accretion of dairy cows .
16793594	0	calcium	46,53	motilin	12,19	calcium	motilin	MESH:D002118	100126231(Tax:10116)	Chemical	Gene	mobilization|compound|START_ENTITY agonists|nmod|mobilization agonists|compound|END_ENTITY	-LSB- Effects of motilin agonists on intracellular calcium mobilization in cultured rat myenteric neurons -RSB- .
20082607	0	calcium	41,48	motilin	11,18	calcium	motilin	MESH:D002118	100126231(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of motilin on intracellular free calcium in cultured smooth muscle cells from the antrum of neonatal rats .
2725711	0	calcium	26,33	motilin	44,51	calcium	motilin	MESH:D002118	100009276(Tax:9986)	Chemical	Gene	stores|compound|START_ENTITY stores|nmod|END_ENTITY	The role of intracellular calcium stores in motilin induced contractions of the longitudinal muscle of the rabbit duodenum .
11761027	0	calcium	25,32	mucin	68,73	calcium	mucin	MESH:D002118	65202(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|nmod|END_ENTITY	Selective involvement of calcium and calcium channels in stimulated mucin secretion from rat colon .
6166202	0	calcium	8,15	mucin	64,69	calcium	mucin	MESH:D002118	65202(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|regulation regulation|nmod|secretion secretion|compound|END_ENTITY	Role of calcium and cAMP in the regulation of rat submandibular mucin secretion .
9041261	0	calcium	89,96	mucin	14,19	calcium	mucin	MESH:D002118	100508689	Chemical	Gene	role|nmod|START_ENTITY Regulation|dep|role Regulation|nmod|secretion secretion|compound|END_ENTITY	Regulation of mucin secretion in human gallbladder epithelial cells : predominant role of calcium and protein_kinase_C .
1362402	0	calcium	56,63	multiple_endocrine_neoplasia_type_1	81,116	calcium	multiple endocrine neoplasia type 1	MESH:D002118	4221	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	Hyperparathyroidism with normal albumin-corrected total calcium in patients with multiple_endocrine_neoplasia_type_1 .
17419759	0	calcium	23,30	mushroom_bodies	52,67	calcium	mushroom bodies	MESH:D002118	40436(Tax:7227)	Chemical	Gene	efflux|compound|START_ENTITY END_ENTITY|nsubj|efflux	Novel stimulus-induced calcium efflux in Drosophila mushroom_bodies .
10231558	0	calcium	98,105	myosin	53,59	calcium	myosin	MESH:D002118	79784	Chemical	Gene	activation|nmod|START_ENTITY characterization|dep|activation characterization|nmod|system system|compound|END_ENTITY	Enzyme kinetic characterization of the smooth muscle myosin phosphorylating system : activation by calcium and calmodulin and possible inhibitory mechanisms of antagonists .
11788342	0	calcium	13,20	myosin	24,30	calcium	myosin	MESH:D002118	79784	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|formation formation|amod|END_ENTITY	Influence of calcium on myosin thick filament formation in intact airway smooth muscle .
12398417	0	calcium	51,58	myosin	20,26	calcium	myosin	MESH:D002118	79784	Chemical	Gene	entry|compound|START_ENTITY role|nmod|entry role|nmod|motor motor|compound|END_ENTITY	Putative role for a myosin motor in store-operated calcium entry .
124603	0	calcium	83,90	myosin	41,47	calcium	myosin	MESH:D002118	79784	Chemical	Gene	presence|nmod|START_ENTITY reaction|nmod|presence reaction|amod|END_ENTITY	-LSB- Study of the stationary kinetics of the myosin ATPase reaction in the presence of calcium -RSB- .
12708747	0	calcium	132,139	myosin	28,34	calcium	myosin	MESH:D002118	79784	Chemical	Gene	MCI-154|compound|START_ENTITY effects|nmod|MCI-154 END_ENTITY|dep|effects	Mg-ATPase and Ca + activated myosin AtPase activity in ventricular myofibrils from non-failing and diseased human hearts -- effects of calcium sensitizing agents MCI-154 , DPI 201-106 , and caffeine .
12756252	1	calcium	72,79	myosin	151,157	calcium	myosin	MESH:D002118	79784	Chemical	Gene	Roles|nmod|START_ENTITY Roles|nmod|END_ENTITY	Roles of calcium binding and dimerization in cellular localization and interaction with myosin .
1527218	0	calcium	39,46	myosin	16,22	calcium	myosin	MESH:D002118	395534(Tax:9031)	Chemical	Gene	chains|nmod|START_ENTITY chains|compound|END_ENTITY	Role of gizzard myosin light chains in calcium binding .
20402494	1	calcium	67,74	myosin	149,155	calcium	myosin	MESH:D002118	79784	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|acl|phosphorylation phosphorylation|nmod|END_ENTITY	Regulation by binding of calcium to the substrate and inhibition of myorod and twitchin phosphorylation by myosin .
20402494	13	calcium	1766,1773	myosin	1798,1804	calcium	myosin	MESH:D002118	79784	Chemical	Gene	activation|nmod|START_ENTITY parallel|nmod|activation catch|nmod|parallel catch|dobj|END_ENTITY	Thus , in parallel to the well-established direct activation by calcium , molluscan catch muscle myosin also regulated its own phosphorylation .
2150676	0	calcium	4,11	myosin	38,44	calcium	myosin	MESH:D002118	79784	Chemical	Gene	dependence|compound|START_ENTITY dependence|nmod|END_ENTITY	The calcium ion dependence of scallop myosin ATPase activity .
23947752	0	calcium	32,39	myosin	4,10	calcium	myosin	MESH:D002118	79784	Chemical	Gene	sensitivity|compound|START_ENTITY tunes|dobj|sensitivity tunes|nsubj|ratio ratio|compound|END_ENTITY	The myosin duty ratio tunes the calcium sensitivity and cooperative activation of the thin filament .
2940816	0	calcium	73,80	myosin	43,49	calcium	myosin	MESH:D002118	395534(Tax:9031)	Chemical	Gene	regulation|compound|START_ENTITY hypothesis|nmod|regulation hypothesis|amod|END_ENTITY	Phosphorylation of chicken_gizzard_myosin : myosin filament hypothesis of calcium regulation .
2961373	0	calcium	10,17	myosin	74,80	calcium	myosin	MESH:D002118	79784	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of calcium and F-actin on the rate of SH2 modification in skeletal myosin .
3026852	0	calcium	64,71	myosin	13,19	calcium	myosin	MESH:D002118	417310(Tax:9031)	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|phosphorylation phosphorylation|compound|END_ENTITY	Brush border myosin heavy chain phosphorylation is regulated by calcium and calmodulin .
4226297	0	calcium	16,23	myosin	52,58	calcium	myosin	MESH:D002118	79784	Chemical	Gene	Interactions|nmod|START_ENTITY tropomyosin|nsubj|Interactions tropomyosin|nmod|END_ENTITY	Interactions of calcium and native tropomyosin with myosin and heavy meromyosin .
6238334	0	calcium	69,76	myosin	20,26	calcium	myosin	MESH:D002118	79784	Chemical	Gene	regulation|nmod|START_ENTITY Movement|dep|regulation Movement|nmod|END_ENTITY	Movement of scallop myosin on Nitella actin filaments : regulation by calcium .
6747823	0	calcium	11,18	myosin	60,66	calcium	myosin	MESH:D002118	79784	Chemical	Gene	antagonists|compound|START_ENTITY Effects|nmod|antagonists Effects|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Effects of calcium antagonists and vasodilators on arterial myosin phosphorylation and actin-myosin interactions .
6774981	1	calcium	136,143	myosin	126,132	calcium	myosin	MESH:D002118	79784	Chemical	Gene	regulation|compound|START_ENTITY Role|nmod|regulation Role|nmod|chain chain|nmod|END_ENTITY	Role of regulatory light chain of myosin in calcium regulation of muscle contraction .
6980220	0	calcium	69,76	myosin	25,31	calcium	myosin	MESH:D002118	79784	Chemical	Gene	ions|compound|START_ENTITY subfragments|nmod|ions subfragments|nsubj|Regulation Regulation|nmod|binding binding|nmod|END_ENTITY	Regulation of binding of myosin subfragments with regulated actin by calcium ions in the presence of magnesium_ATP .
7066306	0	calcium	11,18	myosin	36,42	calcium	myosin	MESH:D002118	79784	Chemical	Gene	Binding|nmod|START_ENTITY Binding|acl|END_ENTITY	Binding of calcium and magnesium to myosin in skeletal muscle myofibrils .
7159573	0	calcium	10,17	myosin	31,37	calcium	myosin	MESH:D002118	79784	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|minifilaments minifilaments|compound|END_ENTITY	Effect of calcium on synthetic myosin minifilaments .
9303697	0	calcium	116,123	myosin	54,60	calcium	myosin	MESH:D002118	79784	Chemical	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	-LSB- Correlation of inhibition of thrombocyte light chain myosin phosphorylation and thrombocyte aggregation by the new calcium and calmodulin antagonist -RSB- .
1420336	0	calcium	80,87	myosin_light-chain_kinase	28,53	calcium	myosin light-chain kinase	MESH:D002118	4638	Chemical	Gene	complex|compound|START_ENTITY END_ENTITY|nmod|complex	The heterodimer calmodulin : myosin_light-chain_kinase as a prototype vertebrate calcium signal transduction complex .
20602360	0	calcium	10,17	neuraminidase	34,47	calcium	neuraminidase	MESH:D002118	4758	Chemical	Gene	Impact|nmod|START_ENTITY END_ENTITY|nsubj|Impact	Impact of calcium on N1 influenza neuraminidase dynamics and binding free energy .
2067026	0	calcium	37,44	neuraminidase	11,24	calcium	neuraminidase	MESH:D002118	4758	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of neuraminidase on cellular calcium and contraction in cultured cardiac myocytes .
10874031	0	calcium	48,55	neuronal_nitric-oxide_synthase	14,44	calcium	neuronal nitric-oxide synthase	MESH:D002118	18125(Tax:10090)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of neuronal_nitric-oxide_synthase by calcium / calmodulin-dependent protein kinase IIalpha through Ser847 phosphorylation in NG108-15 neuronal cells .
19278978	0	calcium	85,92	neuronal_nitric-oxide_synthase	17,47	calcium	neuronal nitric-oxide synthase	MESH:D002118	18125(Tax:10090)	Chemical	Gene	pump|nsubj|START_ENTITY END_ENTITY|acl:relcl|pump	Specific role of neuronal_nitric-oxide_synthase when tethered to the plasma membrane calcium pump in regulating the beta-adrenergic signal in the myocardium .
26536090	0	calcium	21,28	neuropeptide_W	40,54	calcium	neuropeptide W	MESH:D002118	259224(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY channel|nmod|END_ENTITY	Modulation of CaV1 .2 calcium channel by neuropeptide_W regulates vascular myogenic tone via G_protein-coupled_receptor_7 .
1300501	0	calcium	135,142	neuropeptide_Y	14,28	calcium	neuropeptide Y	MESH:D002118	24604(Tax:10116)	Chemical	Gene	influence|nmod|START_ENTITY Co-release|dep|influence Co-release|nmod|END_ENTITY	Co-release of neuropeptide_Y -LRB- NPY -RRB- and noradrenaline from the sympathetic nerve terminals supplying the rat vas deferens ; influence of calcium and the stimulation intensity .
1704288	0	calcium	14,21	neuropeptide_Y	64,78	calcium	neuropeptide Y	MESH:D002118	24604(Tax:10116)	Chemical	Gene	currents|compound|START_ENTITY currents|nmod|neurons neurons|nmod|END_ENTITY	Inhibition of calcium currents in cultured myenteric neurons by neuropeptide_Y : evidence for direct receptor/channel coupling .
18588949	0	calcium	17,24	neuropeptide_Y	37,51	calcium	neuropeptide Y	MESH:D002118	24604(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|nmod|END_ENTITY	Leptin regulated calcium channels of neuropeptide_Y and proopiomelanocortin neurons by activation of different signal pathways .
2153577	0	calcium	77,84	neuropeptide_Y	17,31	calcium	neuropeptide Y	MESH:D002118	4852	Chemical	Gene	mobilization|nmod|START_ENTITY coupled|nmod|mobilization coupled|nsubjpass|receptors receptors|nmod|END_ENTITY	Y1 receptors for neuropeptide_Y are coupled to mobilization of intracellular calcium and inhibition of adenylate cyclase .
3595720	0	calcium	11,18	neuropeptide_Y	69,83	calcium	neuropeptide Y	MESH:D002118	4852	Chemical	Gene	antagonists|compound|START_ENTITY Actions|nmod|antagonists Actions|nmod|END_ENTITY	Actions of calcium antagonists on pre - and postjunctional effects of neuropeptide_Y on human peripheral blood vessels in vitro .
8395583	0	calcium	105,112	neuropeptide_Y	13,27	calcium	neuropeptide Y	MESH:D002118	24604(Tax:10116)	Chemical	Gene	currents|compound|START_ENTITY actions|nmod|currents have|dobj|actions have|nsubj|Agonists Agonists|nmod|subtypes subtypes|amod|END_ENTITY	Agonists for neuropeptide_Y receptor subtypes NPY-1 and NPY-2 have opposite actions on rat nodose neuron calcium currents .
8832072	0	calcium	36,43	neuropeptide_Y	11,25	calcium	neuropeptide Y	MESH:D002118	100724008	Chemical	Gene	current|compound|START_ENTITY Effects|nmod|current Effects|nmod|END_ENTITY	Effects of neuropeptide_Y on L-type calcium current in guinea-pig ventricular myocytes .
8911663	0	calcium	80,87	neuropeptide_Y	109,123	calcium	neuropeptide Y	MESH:D002118	24604(Tax:10116)	Chemical	Gene	proteins|compound|START_ENTITY levels|nmod|proteins levels|advmod|END_ENTITY	The effects of peripheral_nerve_injury of the masseteric nerve on the levels of calcium binding proteins and neuropeptide_Y , and their correlation in the mesencephalic trigeminal nucleus of the rat .
19912956	0	calcium	35,42	neuropeptide_y	89,103	calcium	neuropeptide y	MESH:D002118	24604(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY Role|nmod|channels Role|nmod|hormone hormone|amod|END_ENTITY	Role of multiple voltage-sensitive calcium channels in depolarization-induced release of neuropeptide_y and luteinizing hormone-releasing hormone from rat median eminence-arcuate nucleus .
1849803	0	calcium	51,58	neurotensin	99,110	calcium	neurotensin	MESH:D002118	299757(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY concentration|acl|appearing appearing|dobj|sites sites|amod|END_ENTITY	Neurotensin and neuromedin_N elevate the cytosolic calcium concentration via transiently appearing neurotensin binding sites in cultured rat cortex cells .
2427149	0	calcium	111,118	neurotensin	63,74	calcium	neurotensin	MESH:D002118	299757(Tax:10116)	Chemical	Gene	blockers|compound|START_ENTITY studies|nmod|blockers Involvement|dep|studies Involvement|nmod|channels channels|nmod|activity activity|nmod|END_ENTITY	Involvement of calcium channels in the contractile activity of neurotensin but not acetylcholine : studies with calcium channel blockers and Bay_K_8644 on the rat fundus .
2427149	0	calcium	15,22	neurotensin	63,74	calcium	neurotensin	MESH:D002118	299757(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|nmod|activity activity|nmod|END_ENTITY	Involvement of calcium channels in the contractile activity of neurotensin but not acetylcholine : studies with calcium channel blockers and Bay_K_8644 on the rat fundus .
8292048	0	calcium	41,48	neurotensin	107,118	calcium	neurotensin	MESH:D002118	299757(Tax:10116)	Chemical	Gene	mobilization|compound|START_ENTITY desensitization|nmod|mobilization desensitization|acl|expressing expressing|dobj|receptor receptor|compound|END_ENTITY	Rapid desensitization of agonist-induced calcium mobilization in transfected PC12 cells expressing the rat neurotensin receptor .
25881832	0	calcium	80,87	neurotensin_receptor_type_2	105,132	calcium	neurotensin receptor type 2	MESH:D002118	23620	Chemical	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	The amide linker in nonpeptide neurotensin receptor ligands plays a key role in calcium signaling at the neurotensin_receptor_type_2 .
26346533	0	calcium	56,63	neurotrophin-3	10,24	calcium	neurotrophin-3	MESH:D002118	81737(Tax:10116)	Chemical	Gene	precursor|nmod|START_ENTITY precursor|amod|END_ENTITY	Effect of neurotrophin-3 precursor on glutamate-induced calcium homeostasis deregulation in rat cerebellum granule cells .
26346533	0	calcium	56,63	neurotrophin-3	10,24	calcium	neurotrophin-3	MESH:D002118	81737(Tax:10116)	Chemical	Gene	precursor|nmod|START_ENTITY precursor|amod|END_ENTITY	Effect of neurotrophin-3 precursor on glutamate-induced calcium homeostasis deregulation in rat cerebellum granule cells .
16230388	0	calcium	63,70	notch-1	8,15	calcium	notch-1	MESH:D002118	4851	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of notch-1 and E-cadherin in the differential response to calcium in culturing normal versus malignant prostate cells .
1711410	0	calcium	13,20	ornithine_decarboxylase	48,71	calcium	ornithine decarboxylase	MESH:D002118	4953	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|activity activity|compound|END_ENTITY	Supplemental calcium suppresses colonic mucosal ornithine_decarboxylase activity in elderly patients with adenomatous_polyps .
1780323	0	calcium	24,31	ornithine_decarboxylase	46,69	calcium	ornithine decarboxylase	MESH:D002118	4953	Chemical	Gene	effects|nmod|START_ENTITY antagonist|nsubj|effects antagonist|nmod|induction induction|amod|END_ENTITY	Inhibitory effects of a calcium antagonist on ornithine_decarboxylase induction in pancreatic_cancer cell lines .
2304344	0	calcium	39,46	ornithine_decarboxylase	50,73	calcium	ornithine decarboxylase	MESH:D002118	4953	Chemical	Gene	Absence|nmod|START_ENTITY Absence|nmod|activity activity|amod|END_ENTITY	Absence of effect of supplemental oral calcium on ornithine_decarboxylase -LRB- ODC -RRB- activity in colonic mucosae of healthy individuals with a family history of colorectal_cancer .
2790802	0	calcium	108,115	ornithine_decarboxylase	52,75	calcium	ornithine decarboxylase	MESH:D002118	24609(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY END_ENTITY|dobj|activity	Attenuation of azoxymethane-induced colonic mucosal ornithine_decarboxylase and tyrosine kinase activity by calcium in rats .
2847870	0	calcium	70,77	ornithine_decarboxylase	43,66	calcium	ornithine decarboxylase	MESH:D002118	24609(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Independent and interrelated regulation of ornithine_decarboxylase by calcium and cAMP in fetal rat osteoblasts .
3087287	0	calcium	127,134	ornithine_decarboxylase	29,52	calcium	ornithine decarboxylase	MESH:D002118	18263(Tax:10090)	Chemical	Gene	availability|compound|START_ENTITY dependence|nmod|availability Induction|dep|dependence Induction|nmod|END_ENTITY	Induction of mouse epidermal ornithine_decarboxylase by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate : dependence on calcium availability .
7874572	0	calcium	8,15	ornithine_decarboxylase	37,60	calcium	ornithine decarboxylase	MESH:D002118	18263(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Role of calcium in the regulation of ornithine_decarboxylase enzyme activity in mouse colon_cancer cells .
8824306	0	calcium	28,35	orphanin_FQ	48,59	calcium	orphanin FQ	MESH:D002118	25516(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY Modulation|nmod|channels Modulation|nmod|END_ENTITY	Modulation of voltage-gated calcium channels by orphanin_FQ in freshly dissociated hippocampal neurons .
17293196	0	calcium	40,47	osteoprotegerin	12,27	calcium	osteoprotegerin	MESH:D002118	4982	Chemical	Gene	Relation|nmod|START_ENTITY Relation|nmod|END_ENTITY	Relation of osteoprotegerin to coronary calcium and aortic plaque -LRB- from the Dallas Heart Study -RRB- .
23456427	0	calcium	57,64	osteoprotegerin	87,102	calcium	osteoprotegerin	MESH:D002118	25341(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of fluoride and low versus high levels of dietary calcium on mRNA expression of osteoprotegerin and osteoprotegerin_ligand in the bone of rats .
1417990	0	calcium	8,15	p26	1,4	calcium	p26	MESH:D002118	281447(Tax:9913)	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|dep|protein	-LSB- p26 -- a calcium binding protein from photoreceptor cells in the bovine retina : primary structure and expression in E. _ coli -RSB- .
17760816	0	calcium	145,152	p38_mitogen-activated_protein_kinase	81,117	calcium	p38 mitogen-activated protein kinase	MESH:D002118	1432	Chemical	Gene	concentrations|compound|START_ENTITY concentrations|amod|END_ENTITY	Areca nut extracts-activated secretion of leukotriene_B4 , and phosphorylation of p38_mitogen-activated_protein_kinase and elevated intracellular calcium concentrations in human polymorphonuclear leukocytes .
23976973	0	calcium	29,36	p53	0,3	calcium	p53	MESH:D002118	7157	Chemical	Gene	release|compound|START_ENTITY increases|dobj|release increases|nsubj|END_ENTITY	p53 increases intra-cellular calcium release by transcriptional regulation of calcium channel TRPC6 in GaQ3-treated cancer cells .
25715001	0	calcium	32,39	p53	18,21	calcium	p53	MESH:D002118	7157	Chemical	Gene	homeostasis|compound|START_ENTITY modulates|dobj|homeostasis modulates|nsubj|END_ENTITY	Inside the tumor : p53 modulates calcium homeostasis .
7753047	0	calcium	140,147	p68	136,139	calcium	p68	MESH:D002118	10657	Chemical	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	Binding sites of the Epstein-Barr_virus and C3d_receptor -LRB- CR2 , CD21 -RRB- for its three intracellular ligands , the p53 anti-oncoprotein , the p68 calcium binding protein and the nuclear p120 ribonucleoprotein .
7883762	0	calcium	14,21	p72syk	46,52	calcium	p72syk	MESH:D002118	6850	Chemical	Gene	START_ENTITY|dobj|activation activation|nmod|END_ENTITY	Intracellular calcium dependent activation of p72syk in platelets .
8037774	0	calcium	16,23	pEL98	40,45	calcium	pEL98	MESH:D002118	6275	Chemical	Gene	protein|compound|START_ENTITY Expression|nmod|protein END_ENTITY|nsubj|Expression	Expression of a calcium binding protein pEL98 -LRB- mts1 -RRB- during differentiation of human promyelocytic_leukemia HL-60 cells .
499084	0	calcium	17,24	pancreatic_polypeptide	80,102	calcium	pancreatic polypeptide	MESH:D002118	5539	Chemical	Gene	influence|nmod|START_ENTITY influence|nmod|secretion secretion|nmod|END_ENTITY	The influence of calcium on the basal and acetylcholine-stimulated secretion of pancreatic_polypeptide .
10411552	0	calcium	73,80	parathyroid_hormone	125,144	calcium	parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY acts|nmod|receptor acts|xcomp|reduce reduce|dobj|levels levels|nmod|END_ENTITY	NPS_R-568 : a type II calcimimetic compound that acts on parathyroid cell calcium receptor of rats to reduce plasma levels of parathyroid_hormone and calcium .
10425230	0	calcium	71,78	parathyroid_hormone	114,133	calcium	parathyroid hormone	MESH:D002118	280903(Tax:9913)	Chemical	Gene	concentrations|nmod|START_ENTITY increases|nmod|concentrations required|nsubjpass|increases required|nmod|inhibition inhibition|nmod|secretion secretion|amod|END_ENTITY	Ca2 + - induced increases in steady-state concentrations of intracellular calcium are not required for inhibition of parathyroid_hormone secretion .
10491735	0	calcium	67,74	parathyroid_hormone	39,58	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|gene gene|amod|END_ENTITY	Post-transcriptional regulation of the parathyroid_hormone gene by calcium and phosphate .
10648272	0	calcium	44,51	parathyroid_hormone	62,81	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	concentrations|compound|START_ENTITY concentrations|compound|END_ENTITY	Altered diurnal regulation of blood ionized calcium and serum parathyroid_hormone concentrations during parenteral nutrition .
10804023	0	calcium	16,23	parathyroid_hormone	37,56	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	Effect|nmod|START_ENTITY dialysate|nsubj|Effect dialysate|nmod|secretion secretion|amod|END_ENTITY	Effect of a low calcium dialysate on parathyroid_hormone secretion in diabetic patients on maintenance hemodialysis .
10841518	0	calcium	29,36	parathyroid_hormone	57,76	calcium	parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY Antagonizing|dobj|receptor stimulates|csubj|Antagonizing stimulates|dobj|secretion secretion|amod|END_ENTITY	Antagonizing the parathyroid calcium receptor stimulates parathyroid_hormone secretion and bone formation in osteopenic rats .
11118432	0	calcium	130,137	parathyroid_hormone	38,57	calcium	parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	sufficient|nmod|START_ENTITY sufficient|nsubj|element element|nmod|3 3|amod|END_ENTITY	A conserved cis-acting element in the parathyroid_hormone 3 ' - untranslated region is sufficient for regulation of RNA stability by calcium and phosphate .
1113510	0	calcium	96,103	parathyroid_hormone	26,45	calcium	parathyroid hormone	MESH:D002118	280903(Tax:9913)	Chemical	Gene	response|dep|START_ENTITY changes|nmod|response mechanisms|dep|changes mechanisms|nmod|secretion secretion|amod|END_ENTITY	Subcellular mechanisms of parathyroid_hormone secretion : ultrastructural changes in response to calcium , vitamin_A , vinblastine , and cytochalasin_B .
11250917	0	calcium	84,91	parathyroid_hormone	41,60	calcium	parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY ionized|dobj|concentration ionized|nsubj|fragments fragments|nmod|decrease decrease|compound|END_ENTITY	Synthetic carboxyl-terminal fragments of parathyroid_hormone -LRB- PTH -RRB- decrease ionized calcium concentration in rats by acting on a receptor different from the PTH/PTH-related peptide receptor .
11595617	0	calcium	19,26	parathyroid_hormone	79,98	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	START_ENTITY|nmod|effect effect|nmod|END_ENTITY	Influence of a low calcium and phosphorus diet on the anabolic effect of human parathyroid_hormone -LRB- 1-38 -RRB- in female rats .
12354614	0	calcium	94,101	parathyroid_hormone	50,69	calcium	parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	stability|nmod|START_ENTITY acting|dep|stability acting|nmod|regulation regulation|nmod|END_ENTITY	Cis and trans acting factors in the regulation of parathyroid_hormone -LRB- PTH -RRB- mRNA stability by calcium and phosphate .
12495258	0	calcium	29,36	parathyroid_hormone	71,90	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	milk|compound|START_ENTITY Impact|nmod|milk Impact|nmod|markers markers|amod|END_ENTITY	Impact of supplementary high calcium milk with additional magnesium on parathyroid_hormone and biochemical markers of bone turnover in postmenopausal women .
12671051	0	calcium	52,59	parathyroid_hormone	87,106	calcium	parathyroid hormone	MESH:D002118	19226(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY homeostasis|nmod|END_ENTITY	The calcium-sensing_receptor is required for normal calcium homeostasis independent of parathyroid_hormone .
1313566	0	calcium	266,273	parathyroid_hormone	44,63	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	intracellular|dobj|START_ENTITY intracellular|nsubj|cloning cloning|nmod|receptor receptor|nmod|END_ENTITY	Expression cloning of a common receptor for parathyroid_hormone and parathyroid_hormone-related peptide from rat osteoblast-like cells : a single receptor stimulates intracellular accumulation of both cAMP and inositol_trisphosphates and increases intracellular free calcium .
1395167	0	calcium	26,33	parathyroid_hormone	95,114	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	concentration|compound|START_ENTITY effect|nmod|concentration effect|nmod|secretion secretion|nmod|END_ENTITY	Acute effect of dialysate calcium concentration and intravenous vitamin_D3 on the secretion of parathyroid_hormone in hemodialysis patients .
1422310	0	calcium	85,92	parathyroid_hormone	131,150	calcium	parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|response response|nmod|END_ENTITY	Hormone responses of in vitro bone nodule cells : studies on changes of intracellular calcium and membrane potential in response to parathyroid_hormone and calcitonin .
1459155	0	calcium	69,76	parathyroid_hormone	31,50	calcium	parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	G|compound|START_ENTITY influence|nmod|G Renal_insufficiency|dep|influence Renal_insufficiency|acl|induced induced|nmod|END_ENTITY	Renal_insufficiency induced by parathyroid_hormone : influence of the calcium antagonist G 6070 .
15037630	0	calcium	171,178	parathyroid_hormone	15,34	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	increases|dobj|START_ENTITY increases|nsubj|Stimulation Stimulation|nmod|END_ENTITY	Stimulation by parathyroid_hormone of a NHERF-1-assembled complex consisting of the parathyroid_hormone I receptor , phospholipase Cbeta , and actin increases intracellular calcium in opossum kidney cells .
15037630	0	calcium	171,178	parathyroid_hormone	84,103	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	increases|dobj|START_ENTITY increases|nsubj|Stimulation Stimulation|nmod|parathyroid_hormone parathyroid_hormone|nmod|complex complex|acl|consisting consisting|nmod|receptor receptor|amod|END_ENTITY	Stimulation by parathyroid_hormone of a NHERF-1-assembled complex consisting of the parathyroid_hormone I receptor , phospholipase Cbeta , and actin increases intracellular calcium in opossum kidney cells .
15334204	0	calcium	110,117	parathyroid_hormone	78,97	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	Response to an oral calcium load in nephrolithiasis patients with fluctuating parathyroid_hormone and ionized calcium levels .
15334204	0	calcium	20,27	parathyroid_hormone	78,97	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	load|compound|START_ENTITY Response|nmod|load nephrolithiasis|nsubj|Response nephrolithiasis|advcl|fluctuating fluctuating|dobj|levels levels|amod|END_ENTITY	Response to an oral calcium load in nephrolithiasis patients with fluctuating parathyroid_hormone and ionized calcium levels .
15632475	0	calcium	72,79	parathyroid_hormone	18,37	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	receptor|compound|START_ENTITY control|nmod|receptor inhibiting|nmod|control inhibiting|dobj|secretion secretion|amod|END_ENTITY	-LSB- Drugs inhibiting parathyroid_hormone -LRB- PTH -RRB- secretion by control of the calcium receptor -LRB- calcimimetics -RRB- -- effect on the set point of calcium-regulated PTH secretion -RSB- .
15886497	0	calcium	85,92	parathyroid_hormone	13,32	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	ionized|dobj|START_ENTITY ionized|nsubj|Secretion Secretion|nmod|oscillates oscillates|amod|END_ENTITY	Secretion of parathyroid_hormone oscillates depending on the change in serum ionized calcium during hemodialysis and may affect bone metabolism .
1606745	0	calcium	62,69	parathyroid_hormone	14,33	calcium	parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|END_ENTITY	Comparison of parathyroid_hormone and calcitonin on rat renal calcium and magnesium transport .
16181594	0	calcium	71,78	parathyroid_hormone	14,33	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	values|compound|START_ENTITY conjunction|nmod|values levels|nmod|conjunction levels|compound|END_ENTITY	Postoperative parathyroid_hormone levels in conjunction with corrected calcium values as a predictor of post-thyroidectomy hypocalcemia : review of outcomes 1 year after the implementation of a new protocol .
16219713	0	calcium	77,84	parathyroid_hormone	32,51	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	forms|nmod|START_ENTITY regulation|dep|forms regulation|acl|circulating circulating|dobj|END_ENTITY	Acute regulation of circulating parathyroid_hormone -LRB- PTH -RRB- molecular forms by calcium : utility of PTH fragments/PTH -LRB- 1-84 -RRB- ratios derived from three generations of PTH assays .
16269381	0	calcium	62,69	parathyroid_hormone	71,90	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	Effects|appos|START_ENTITY END_ENTITY|nsubj|Effects	Effects of gastric bypass procedures on bone_mineral_density , calcium , parathyroid_hormone , and vitamin_D .
16687470	0	calcium	8,15	parathyroid_hormone	46,65	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	channels|compound|START_ENTITY channels|nmod|receptor receptor|compound|END_ENTITY	Role of calcium channels in carboxyl-terminal parathyroid_hormone receptor signaling .
16840548	0	calcium	47,54	parathyroid_hormone	123,142	calcium	parathyroid hormone	MESH:D002118	19226(Tax:10090)	Chemical	Gene	internalization|nmod|START_ENTITY Impact|nmod|internalization homeostasis|nsubj|Impact homeostasis|nmod|mice mice|acl|expressing expressing|dobj|END_ENTITY	Impact of impaired receptor internalization on calcium homeostasis in knock-in mice expressing a phosphorylation-deficient parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide_receptor .
1714026	0	calcium	31,38	parathyroid_hormone	80,99	calcium	parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	currents|compound|START_ENTITY types|nmod|currents types|nmod|END_ENTITY	Two types of voltage-dependent calcium channel currents and their modulation by parathyroid_hormone in neonatal rat ventricular cells .
1720895	0	calcium	20,27	parathyroid_hormone	29,48	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	START_ENTITY|appos|metabolites metabolites|amod|monoamine monoamine|dep|END_ENTITY	Cerebrospinal fluid calcium , parathyroid_hormone , and monoamine and purine metabolites and the blood-brain barrier function in primary_hyperparathyroidism .
1740486	0	calcium	88,95	parathyroid_hormone	30,49	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	concentration|compound|START_ENTITY circulating|nmod|concentration circulating|dobj|immunoheterogeneity immunoheterogeneity|amod|END_ENTITY	The modulation of circulating parathyroid_hormone immunoheterogeneity in man by ionized calcium concentration .
1768811	0	calcium	81,88	parathyroid_hormone	8,27	calcium	parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	levels|nmod|START_ENTITY increases|dobj|levels increases|nsubj|excess excess|compound|END_ENTITY	Chronic parathyroid_hormone excess in vivo increases resting levels of cytosolic calcium in brain synaptosomes : studies in the presence and absence of chronic_renal_failure .
17703091	0	calcium	23,30	parathyroid_hormone	43,62	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	START_ENTITY|appos|pressure pressure|amod|nondipper nondipper|dep|END_ENTITY	Relation between serum calcium , phosphate , parathyroid_hormone and ` nondipper ' circadian blood pressure variability profile in patients with normal renal function .
1861632	0	calcium	74,81	parathyroid_hormone	16,35	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	response|nmod|START_ENTITY response|nmod|END_ENTITY	The response of parathyroid_hormone to specific changes in either ionized calcium , ionized magnesium , or protein-bound calcium in humans .
186180	1	calcium	44,51	parathyroid_hormone	82,101	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	isotopes|compound|START_ENTITY using|dobj|isotopes using|nmod|END_ENTITY	Studies using calcium isotopes and immunoassays for parathyroid_hormone and calcitonin .
19185400	0	calcium	23,30	parathyroid_hormone	78,97	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	effect|nmod|START_ENTITY supplementation|nsubj|effect supplementation|nmod|END_ENTITY	The effect of combined calcium and vitamin_D3 supplementation on serum intact parathyroid_hormone in moderate CKD .
194445	0	calcium	14,21	parathyroid_hormone	60,79	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|nmod|END_ENTITY	The effect of calcium and dibutryl-cAMP on the secretion of parathyroid_hormone by human parathyroid_adenomas in organ culture .
195984	0	calcium	72,79	parathyroid_hormone	11,30	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	cyclic_AMP|nmod|START_ENTITY Effects|nmod|cyclic_AMP Effects|nmod|END_ENTITY	Effects of parathyroid_hormone on cyclic_AMP , cyclic_GMP , and efflux of calcium in isolated renal tubules .
19666939	0	calcium	5,12	parathyroid_hormone	65,84	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	supplementation|compound|START_ENTITY reverses|nsubj|supplementation reverses|dobj|pattern pattern|nmod|resistance resistance|amod|END_ENTITY	Oral calcium supplementation reverses the biochemical pattern of parathyroid_hormone resistance in underprivileged Indian toddlers .
19781123	0	calcium	149,156	parathyroid_hormone	61,80	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	intake|compound|START_ENTITY affects|nmod|intake affects|dobj|concentration concentration|compound|END_ENTITY	Low calcium : phosphorus ratio in habitual diets affects serum parathyroid_hormone concentration and calcium metabolism in healthy women with adequate calcium intake .
19781123	0	calcium	4,11	parathyroid_hormone	61,80	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	START_ENTITY|parataxis|affects affects|dobj|concentration concentration|compound|END_ENTITY	Low calcium : phosphorus ratio in habitual diets affects serum parathyroid_hormone concentration and calcium metabolism in healthy women with adequate calcium intake .
20148911	0	calcium	97,104	parathyroid_hormone	44,63	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	supplementation|compound|START_ENTITY years|nmod|supplementation influence|nmod|years influence|nmod|status status|nmod|mass mass|compound|END_ENTITY	Discrepant influence of vitamin_D status on parathyroid_hormone and bone mass after two years of calcium supplementation .
20406649	0	calcium	88,95	parathyroid_hormone	24,43	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	concentration|compound|START_ENTITY ionized|dobj|concentration ionized|nsubj|model model|nmod|response response|amod|END_ENTITY	A mathematical model of parathyroid_hormone response to acute changes in plasma ionized calcium concentration in humans .
20558332	0	calcium	144,151	parathyroid_hormone	67,86	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	effects|nmod|START_ENTITY Involvement|dep|effects Involvement|nmod|GCMB GCMB|nmod|regulation regulation|nmod|gene gene|compound|END_ENTITY	Involvement of GCMB in the transcriptional regulation of the human parathyroid_hormone gene in a parathyroid-derived cell line PT-r : effects of calcium and 1,25 -LRB- OH -RRB- 2D3 .
20859873	0	calcium	88,95	parathyroid_hormone	51,70	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	levels|compound|START_ENTITY level|nmod|levels level|amod|END_ENTITY	Predicting hypocalcemia after total thyroidectomy : parathyroid_hormone level vs. serial calcium levels .
2098768	0	calcium	49,56	parathyroid_hormone	11,30	calcium	parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|nmod|transport	Effects of parathyroid_hormone and calcitonin on calcium transport of rat cultured striatum cells .
210311	0	calcium	119,126	parathyroid_hormone	59,78	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	urolithiasis|compound|START_ENTITY END_ENTITY|nmod|urolithiasis	-LSB- Evaluation of renal_cyclic_adenosine_monophosphate , serum parathyroid_hormone and phosphate reabsorption in recurrent calcium urolithiasis , healthy controls and hyperparathyroidism -LRB- author 's transl -RRB- -RSB- .
2108792	0	calcium	89,96	parathyroid_hormone	117,136	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	levels|compound|START_ENTITY Heterogeneity|nmod|levels Heterogeneity|nmod|END_ENTITY	Heterogeneity of pseudohypoparathyroidism_type_I from the aspect of urinary excretion of calcium and serum levels of parathyroid_hormone .
21489574	0	calcium	6,13	parathyroid_hormone	106,125	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	correlated|nsubjpass|START_ENTITY correlated|advcl|fasting fasting|dobj|resistance resistance|appos|independent independent|nmod|END_ENTITY	Serum calcium is positively correlated with fasting plasma_glucose and insulin resistance , independent of parathyroid_hormone , in male patients with type_2_diabetes_mellitus .
22000728	0	calcium	20,27	parathyroid_hormone	46,65	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	concentrations|compound|START_ENTITY concentrations|nmod|balance balance|compound|END_ENTITY	Effect of dialysate calcium concentrations on parathyroid_hormone and calcium balance during a single dialysis session using bicarbonate hemodialysis : a crossover clinical trial .
22018100	0	calcium	15,22	parathyroid_hormone	131,150	calcium	parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	balance|compound|START_ENTITY Improvement|nmod|balance associated|nsubjpass|Improvement associated|nmod|induction induction|nmod|levels levels|compound|END_ENTITY	Improvement of calcium balance by Fructus Ligustri Lucidi extract in mature female rats was associated with the induction of serum parathyroid_hormone levels .
22456781	0	calcium	116,123	parathyroid_hormone	80,99	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	supplementation|compound|START_ENTITY circulating|nmod|supplementation circulating|dobj|END_ENTITY	Malic enzyme gene polymorphism is associated with responsiveness in circulating parathyroid_hormone after long-term calcium supplementation .
225161	0	calcium	10,17	parathyroid_hormone	60,79	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	administration|compound|START_ENTITY Effect|nmod|administration Effect|acl|END_ENTITY	Effect of calcium administration on renal responsiveness to parathyroid_hormone in pseudohypoparathyroidism_type_I and II -- in comparison with normals , idiopathic_and_surgical_hypoparathyroidism .
2254716	0	calcium	90,97	parathyroid_hormone	60,79	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	metabolic_disorders|compound|START_ENTITY assays|nmod|metabolic_disorders assays|nsubj|applicability applicability|nmod|END_ENTITY	Diagnostic applicability of intact and midregion/C-terminal parathyroid_hormone assays in calcium metabolic_disorders .
22764192	0	calcium	40,47	parathyroid_hormone	99,118	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	changes|compound|START_ENTITY impact|nmod|changes impact|dep|role role|nmod|END_ENTITY	Biological impact of targeted dialysate calcium changes in haemodialysis patients : the key role of parathyroid_hormone .
23045165	0	calcium	10,17	parathyroid_hormone	57,76	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	insufficiencies|compound|START_ENTITY insufficiencies|nmod|END_ENTITY	Impact of calcium and vitamin_D insufficiencies on serum parathyroid_hormone and bone_mineral_density : analysis of the fourth and fifth Korea National Health and Nutrition Examination Survey -LRB- KNHANES IV-3 , 2009 and KNHANES V-1 , 2010 -RRB- .
2322693	0	calcium	199,206	parathyroid_hormone	77,96	calcium	parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	diet|compound|START_ENTITY consuming|dobj|diet function|xcomp|consuming function|nsubj|Effects Effects|nmod|clomiphene clomiphene|nmod|vivo vivo|nmod|effects effects|nmod|END_ENTITY	Effects of clomiphene and tamoxifen in vivo on the bone-resorbing effects of parathyroid_hormone and of high oral doses of calcitriol -LRB- 1,25 -LRB- OH -RRB- 2D3 -RRB- in rats with intact ovarian function consuming low calcium diet .
24192818	0	calcium	37,44	parathyroid_hormone	118,137	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	levels|nmod|START_ENTITY Maintaining|dobj|levels associated|csubjpass|Maintaining associated|nmod|levels levels|compound|END_ENTITY	Maintaining normal levels of ionized calcium during citrate-based renal replacement therapy is associated with stable parathyroid_hormone levels .
2459912	0	calcium	14,21	parathyroid_hormone	25,44	calcium	parathyroid hormone	MESH:D002118	280903(Tax:9913)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|mRNA mRNA|amod|END_ENTITY	Regulation by calcium of parathyroid_hormone mRNA in cultured parathyroid tissue .
24619764	0	calcium	146,153	parathyroid_hormone	24,43	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	cardiovascular_diseases|dep|START_ENTITY based|nmod|cardiovascular_diseases interval|acl|based individuals|nmod|interval exclusion|nmod|individuals END_ENTITY|dep|exclusion	Reference intervals for parathyroid_hormone for 70-year-old males and females : exclusion of individuals from the reference interval based on sex , calcium , diabetes , cardiovascular_diseases or reduced kidney function has limited effects on the interval .
24976761	0	calcium	51,58	parathyroid_hormone	16,35	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	intake|compound|START_ENTITY response|nmod|intake response|amod|END_ENTITY	Modeling of the parathyroid_hormone response after calcium intake in healthy subjects .
25048492	0	calcium	69,76	parathyroid_hormone	38,57	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	excretion|compound|START_ENTITY END_ENTITY|nmod|excretion	Role of 1,25-dihydroxy _ vitamin_D3 and parathyroid_hormone in urinary calcium excretion in calcium stone formers .
25048492	0	calcium	90,97	parathyroid_hormone	38,57	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	formers|compound|START_ENTITY excretion|nmod|formers END_ENTITY|nmod|excretion	Role of 1,25-dihydroxy _ vitamin_D3 and parathyroid_hormone in urinary calcium excretion in calcium stone formers .
2505183	0	calcium	42,49	parathyroid_hormone	53,72	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	Effect of direction and rate of change of calcium on parathyroid_hormone secretion in uraemia .
25053220	0	calcium	114,121	parathyroid_hormone	9,28	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	supplementation|compound|START_ENTITY need|nmod|supplementation predicts|dobj|need obtained|advcl|predicts obtained|nsubj|level level|compound|END_ENTITY	A single parathyroid_hormone level obtained 4 hours after total thyroidectomy predicts the need for postoperative calcium supplementation .
25136569	0	calcium	34,41	parathyroid_hormone	11,30	calcium	parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	ions|compound|START_ENTITY END_ENTITY|nmod|ions	Effects of parathyroid_hormone on calcium ions in rat bone marrow mesenchymal stem cells .
25191614	0	calcium	126,133	parathyroid_hormone	51,70	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	doses|nmod|START_ENTITY calcium|nmod|doses calcium|amod|END_ENTITY	Postprandial metabolic responses of serum calcium , parathyroid_hormone and C-telopeptide_of_type_I_collagen to three doses of calcium delivered in milk .
2536396	0	calcium	49,56	parathyroid_hormone	11,30	calcium	parathyroid hormone	MESH:D002118	100351309(Tax:9986)	Chemical	Gene	concentration|compound|START_ENTITY END_ENTITY|nmod|concentration	Effects of parathyroid_hormone on cytosolic free calcium concentration in individual rabbit connecting tubules .
2540213	0	calcium	38,45	parathyroid_hormone	15,34	calcium	parathyroid hormone	MESH:D002118	403986(Tax:9615)	Chemical	Gene	absorption|compound|START_ENTITY Stimulation|nmod|absorption Stimulation|nmod|END_ENTITY	Stimulation by parathyroid_hormone of calcium absorption in confluent Madin-Darby canine kidney cells .
2667963	0	calcium	13,20	parathyroid_hormone	45,64	calcium	parathyroid hormone	MESH:D002118	280903(Tax:9913)	Chemical	Gene	dose-response|compound|START_ENTITY curve|nsubj|dose-response curve|nmod|secretion secretion|amod|END_ENTITY	The biphasic calcium dose-response curve for parathyroid_hormone secretion in electropermeabilized adult bovine parathyroid cells .
26880460	0	calcium	57,64	parathyroid_hormone	4,23	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	induced|nmod|START_ENTITY status|acl|induced status|compound|END_ENTITY	Low parathyroid_hormone status induced by high dialysate calcium is an independent risk factor for cardiovascular_death in hemodialysis patients .
27000502	0	calcium	134,141	parathyroid_hormone	4,23	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	regulate|dobj|START_ENTITY regulate|nsubj|PTH2R PTH2R|amod|END_ENTITY	The parathyroid_hormone second receptor PTH2R , and its ligand tuberoinfundibular peptide of 39 residues TIP39 , regulate intracellular calcium and influence keratinocyte differentiation .
2715961	0	calcium	43,50	parathyroid_hormone	7,26	calcium	parathyroid hormone	MESH:D002118	403986(Tax:9615)	Chemical	Gene	concentration|compound|START_ENTITY END_ENTITY|dobj|concentration	Intact parathyroid_hormone assay and total calcium concentration in the diagnosis of disorders_of_calcium_metabolism in dogs .
2769152	0	calcium	87,94	parathyroid_hormone	30,49	calcium	parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	availability|compound|START_ENTITY alterations|nmod|availability influence|nmod|alterations metabolism|dep|influence metabolism|nmod|END_ENTITY	Peripheral metabolism of -LSB- 35S -RSB- parathyroid_hormone in vivo : influence of alterations in calcium availability and parathyroid status .
2843523	0	calcium	75,82	parathyroid_hormone	24,43	calcium	parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	ion|compound|START_ENTITY effects|nmod|ion effects|nmod|END_ENTITY	Differential effects of parathyroid_hormone and its analogues on cytosolic calcium ion and cAMP levels in cultured rat osteoblast-like cells .
2920098	0	calcium	79,86	parathyroid_hormone	41,60	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Saline infusion causes rapid increase in parathyroid_hormone and intracellular calcium levels .
2994886	0	calcium	105,112	parathyroid_hormone	39,58	calcium	parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY model|dep|role model|nmod|action action|nmod|END_ENTITY	A two-receptor model for the action of parathyroid_hormone on osteoblasts : a role for intracellular free calcium and cAMP .
2997292	0	calcium	102,109	parathyroid_hormone	14,33	calcium	parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|amod|END_ENTITY	Inhibition of parathyroid_hormone secretion and parathyroid_hormone-independent diminution of tubular calcium reabsorption by WR-2721 , a unique hypocalcemic agent .
3033217	0	calcium	43,50	parathyroid_hormone	10,29	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	transport|compound|START_ENTITY fragments|nmod|transport fragments|nsubj|Effect Effect|nmod|END_ENTITY	Effect of parathyroid_hormone fragments on calcium transport in toad bladder .
3063205	0	calcium	72,79	parathyroid_hormone	30,49	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	metabolism|compound|START_ENTITY disorders|nmod|metabolism END_ENTITY|nmod|disorders	The use of an intact molecule parathyroid_hormone assay in disorders of calcium metabolism .
3142533	0	calcium	93,100	parathyroid_hormone	10,29	calcium	parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY ionized|dobj|concentration ionized|nsubj|Effect Effect|nmod|fragments fragments|amod|END_ENTITY	Effect of parathyroid_hormone and parathyroid_hormone fragments on the intracellular ionized calcium concentration in an osteoblast cell line .
334518	0	calcium	11,18	parathyroid_hormone	62,81	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	Effects|nmod|START_ENTITY ionophores|nsubj|Effects ionophores|nmod|synthesis synthesis|nmod|END_ENTITY	Effects of calcium ionophores on the synthesis and release of parathyroid_hormone .
3351432	0	calcium	46,53	parathyroid_hormone	70,89	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	concentrations|compound|START_ENTITY Relationship|nmod|concentrations END_ENTITY|nsubj|Relationship	Relationship between external and cytoplasmic calcium concentrations , parathyroid_hormone release and weight of parathyroid_glands in human hyperparathyroidism .
3370224	0	calcium	33,40	parathyroid_hormone	71,90	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	evidence|nmod|START_ENTITY evidence|nmod|messenger messenger|nmod|release release|amod|END_ENTITY	Kinetic evidence for cytoplasmic calcium as an inhibitory messenger in parathyroid_hormone release .
3421328	0	calcium	11,18	parathyroid_hormone	49,68	calcium	parathyroid hormone	MESH:D002118	280903(Tax:9913)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|protein_I protein_I|compound|END_ENTITY	Effects of calcium on synthesis and secretion of parathyroid_hormone and secretory protein_I .
3455618	0	calcium	93,100	parathyroid_hormone	18,37	calcium	parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY Increase|dep|effects Increase|nmod|concentration concentration|compound|END_ENTITY	Increase in serum parathyroid_hormone concentration in the lactating rat : effects of dietary calcium and lactational intensity .
3508718	0	calcium	28,35	parathyroid_hormone	51,70	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	decreasing|dobj|START_ENTITY decreasing|advcl|circulating circulating|dobj|metabolites metabolites|amod|END_ENTITY	Effects of decreasing serum calcium on circulating parathyroid_hormone and vitamin_D metabolites in normocalcaemic and hypercalcaemic patients treated with APD .
3706546	0	calcium	17,24	parathyroid_hormone	28,47	calcium	parathyroid hormone	MESH:D002118	100351309(Tax:9986)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|actions actions|amod|END_ENTITY	Possible role of calcium in parathyroid_hormone actions in rabbit renal proximal tubules .
3731786	0	calcium	15,22	parathyroid_hormone	50,69	calcium	parathyroid hormone	MESH:D002118	100034104(Tax:9796)	Chemical	Gene	Alterations|nmod|START_ENTITY END_ENTITY|nsubj|Alterations	Alterations in calcium , phosphorus and C-terminal parathyroid_hormone levels in equine acute_renal_disease .
3740268	0	calcium	44,51	parathyroid_hormone	11,30	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of parathyroid_hormone on cytosolic calcium in renal proximal tubular primary cultures .
3791650	0	calcium	108,115	parathyroid_hormone	15,34	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	pseudohypoparathyroidism_type_I|nmod|START_ENTITY Suppression|nmod|pseudohypoparathyroidism_type_I Suppression|nmod|activity activity|amod|END_ENTITY	Suppression of parathyroid_hormone inhibitory activity of plasma in pseudohypoparathyroidism_type_I by i.v. calcium .
3819869	0	calcium	19,26	parathyroid_hormone	38,57	calcium	parathyroid hormone	MESH:D002118	280903(Tax:9913)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of dietary calcium and age on parathyroid_hormone , calcitonin and serum and milk minerals in the periparturient dairy cow .
3840495	0	calcium	28,35	parathyroid_hormone	84,103	calcium	parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	ionized|dobj|START_ENTITY Evidence|dep|ionized regulate|nsubj|Evidence regulate|dobj|serum serum|nmod|END_ENTITY	Evidence that blood ionized calcium can regulate serum 1,25 -LRB- OH -RRB- 2D3 independently of parathyroid_hormone and phosphorus in the rat .
3840736	0	calcium	53,60	parathyroid_hormone	10,29	calcium	parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|dep|effects	Bioactive parathyroid_hormone in the rat : effects of calcium and calcitriol .
3930119	0	calcium	6,13	parathyroid_hormone	63,82	calcium	parathyroid hormone	MESH:D002118	403986(Tax:9615)	Chemical	Gene	influence|nsubj|START_ENTITY influence|dobj|extraction extraction|nmod|END_ENTITY	Serum calcium does not influence the extraction of 125I-bovine parathyroid_hormone by the dog liver in vivo .
3940894	0	calcium	106,113	parathyroid_hormone	15,34	calcium	parathyroid hormone	MESH:D002118	280903(Tax:9913)	Chemical	Gene	decrease|nmod|START_ENTITY associated|nmod|decrease associated|nsubjpass|Stimulation Stimulation|nmod|secretion secretion|amod|END_ENTITY	Stimulation of parathyroid_hormone secretion by phorbol_esters is associated with a decrease of cytosolic calcium .
3940928	0	calcium	160,167	parathyroid_hormone	33,52	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	Changes|nmod|START_ENTITY Changes|nmod|calcium calcium|amod|END_ENTITY	Changes in the concentrations of parathyroid_hormone and ionic calcium in the plasma of laying hens during the egg cycle in relation to dietary deficiencies of calcium and vitamin_D .
3998647	0	calcium	35,42	parathyroid_hormone	88,107	calcium	parathyroid hormone	MESH:D002118	280903(Tax:9913)	Chemical	Gene	inhibition|nmod|START_ENTITY Evidence|nmod|inhibition uptake|nsubj|Evidence uptake|nmod|END_ENTITY	Evidence for a novel inhibition of calcium uptake into chick bone in response to bovine parathyroid_hormone -LRB- 1-34 -RRB- or 16 , 16-dimethyl_prostaglandin_E2 in vivo .
4050412	0	calcium	95,102	parathyroid_hormone	27,46	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	therapy|compound|START_ENTITY Circulating|nmod|therapy Circulating|dobj|levels levels|compound|END_ENTITY	Circulating immunoreactive parathyroid_hormone levels in premature infants and the response to calcium therapy .
408151	0	calcium	64,71	parathyroid_hormone	25,44	calcium	parathyroid hormone	MESH:D002118	280903(Tax:9913)	Chemical	Gene	interactions|nmod|START_ENTITY stimulation|dep|interactions stimulation|nmod|END_ENTITY	Vitamin_A stimulation of parathyroid_hormone : interactions with calcium , hydrocortisone , and vitamin_E in bovine parathyroid tissues and effects of vitamin_A in man .
434208	0	calcium	18,25	parathyroid_hormone	40,59	calcium	parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	handling|nmod|START_ENTITY handling|dep|influence influence|nmod|D3 D3|amod|END_ENTITY	Renal handling of calcium : influence of parathyroid_hormone and 1,25-dihydroxyvitamin _ D3 .
489718	0	calcium	61,68	parathyroid_hormone	120,139	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	pseudohypoparathyroidism|nmod|START_ENTITY patient|nmod|pseudohypoparathyroidism _|amod|patient END_ENTITY|nsubj|_	A patient with pseudohypoparathyroidism with increased serum calcium and 1 alpha , _ 25-dihydroxyvitamin_D after exogenous parathyroid_hormone administration .
4972567	0	calcium	47,54	parathyroid_hormone	20,39	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	Effects of purified parathyroid_hormone on the calcium metabolism of monkey kidney cells .
5574397	2	calcium	79,86	parathyroid_hormone	117,136	calcium	parathyroid hormone	MESH:D002118	280903(Tax:9913)	Chemical	Gene	START_ENTITY|nmod|synthesis synthesis|nmod|END_ENTITY	The effect of calcium and magnesium on synthesis of parathyroid_hormone isolated from bovine parathyroid tissue and incubation medium .
6281301	0	calcium	64,71	parathyroid_hormone	106,125	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	START_ENTITY|nmod|response response|nmod|END_ENTITY	Idiopathic hypercalciuria : hydrochlorothiazide decrease urinary calcium without altered renal response to parathyroid_hormone .
6294762	0	calcium	75,82	parathyroid_hormone	52,71	calcium	parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	phosphate|compound|START_ENTITY END_ENTITY|nmod|phosphate	Differences in effects of amino-terminal and intact parathyroid_hormone on calcium , phosphate , and cAMP excretion by the isolated perfused rat kidney .
6300634	0	calcium	16,23	parathyroid_hormone	69,88	calcium	parathyroid hormone	MESH:D002118	403986(Tax:9615)	Chemical	Gene	START_ENTITY|nmod|effects effects|nmod|END_ENTITY	Potentiation by calcium of the proximal tubular transport effects of parathyroid_hormone .
6308077	0	calcium	77,84	parathyroid_hormone	15,34	calcium	parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY effects|nmod|transport effects|nmod|END_ENTITY	The effects of parathyroid_hormone , calcitonin , and vitamin_D metabolites on calcium transport in the secretory rat enamel organ .
6313451	0	calcium	81,88	parathyroid_hormone	21,40	calcium	parathyroid hormone	MESH:D002118	280903(Tax:9913)	Chemical	Gene	absence|nmod|START_ENTITY stimulates|nmod|absence stimulates|dobj|release release|amod|END_ENTITY	Potassium stimulates parathyroid_hormone release in the absence of extracellular calcium .
6330156	0	calcium	103,110	parathyroid_hormone	70,89	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	lithium|nmod|START_ENTITY lithium|nmod|suppressibility suppressibility|nmod|secretion secretion|amod|END_ENTITY	The effect of short term lithium administration on suppressibility of parathyroid_hormone secretion by calcium in vivo .
6461466	0	calcium	23,30	parathyroid_hormone	100,119	calcium	parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	Increase|nmod|START_ENTITY treated|nsubj|Increase treated|nmod|END_ENTITY	Increase of whole-body calcium and skeletal mass in normal and osteoporotic adult rats treated with parathyroid_hormone .
6548427	0	calcium	25,32	parathyroid_hormone	126,145	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	absorption|nmod|START_ENTITY absorption|dep|response response|nmod|1-34 1-34|amod|END_ENTITY	Intestinal absorption of calcium in greyhounds : the response to intermittent and continuous administration of human synthetic parathyroid_hormone fragment 1-34 -LRB- hPTH 1-34 -RRB- .
6643490	0	calcium	15,22	parathyroid_hormone	33,52	calcium	parathyroid hormone	MESH:D002118	280903(Tax:9913)	Chemical	Gene	Stimulation|nmod|START_ENTITY uptake|nsubj|Stimulation uptake|nmod|END_ENTITY	Stimulation of calcium uptake by parathyroid_hormone in renal brush-border membrane vesicles .
6743715	1	calcium	73,80	parathyroid_hormone	122,141	calcium	parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY immunoreactive|nsubj|transport immunoreactive|dobj|END_ENTITY	Intestinal calcium transport , serum calcium , immunoreactive parathyroid_hormone and calcitonin .
6743715	1	calcium	98,105	parathyroid_hormone	122,141	calcium	parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	transport|appos|START_ENTITY immunoreactive|nsubj|transport immunoreactive|dobj|END_ENTITY	Intestinal calcium transport , serum calcium , immunoreactive parathyroid_hormone and calcitonin .
6749074	0	calcium	83,90	parathyroid_hormone	24,43	calcium	parathyroid hormone	MESH:D002118	403986(Tax:9615)	Chemical	Gene	transport|compound|START_ENTITY Difference|nmod|transport Difference|nmod|END_ENTITY	Difference between 1-84 parathyroid_hormone and the 1-34 fragment on renal tubular calcium transport in the dog .
6787928	0	calcium	5,12	parathyroid_hormone	56,75	calcium	parathyroid hormone	MESH:D002118	403986(Tax:9615)	Chemical	Gene	clamp|compound|START_ENTITY clamp|dep|effect effect|nmod|hypocalcemia hypocalcemia|nmod|secretion secretion|amod|END_ENTITY	The `` calcium clamp '' : effect of constant hypocalcemia on parathyroid_hormone secretion .
6854136	0	calcium	17,24	parathyroid_hormone	74,93	calcium	parathyroid hormone	MESH:D002118	403986(Tax:9615)	Chemical	Gene	concentration|compound|START_ENTITY concentration|nmod|rate rate|nmod|END_ENTITY	Effect of plasma calcium concentration on the metabolic clearance rate of parathyroid_hormone in the dog .
7054214	0	calcium	54,61	parathyroid_hormone	23,42	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|regulation regulation|nmod|END_ENTITY	Abnormal regulation of parathyroid_hormone release by calcium in secondary_hyperparathyroidism due to chronic_renal_failure .
711140	0	calcium	11,18	parathyroid_hormone	70,89	calcium	parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	intake|compound|START_ENTITY Effects|nmod|intake immunoreactive|nsubj|Effects immunoreactive|dobj|levels levels|amod|END_ENTITY	Effects of calcium intake and renal function on plasma immunoreactive parathyroid_hormone levels in rats .
7187765	0	calcium	76,83	parathyroid_hormone	17,36	calcium	parathyroid hormone	MESH:D002118	101120013	Chemical	Gene	magnesium|compound|START_ENTITY phosphorus|compound|magnesium influence|nmod|phosphorus influence|nmod|END_ENTITY	The influence of parathyroid_hormone and calcitonin on urinary excretion of calcium , magnesium and inorganic phosphorus in chronically catheterized foetal lambs in utero .
7241017	0	calcium	28,35	parathyroid_hormone	70,89	calcium	parathyroid hormone	MESH:D002118	102168368	Chemical	Gene	Maintenance|nmod|START_ENTITY Maintenance|nmod|END_ENTITY	Maintenance of secretion of calcium and magnesium during infusions of parathyroid_hormone to lactating goats .
7404129	0	calcium	63,70	parathyroid_hormone	27,46	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	metabolism|compound|START_ENTITY disorders|nmod|metabolism END_ENTITY|nmod|disorders	Measurement of human serum parathyroid_hormone in disorders of calcium metabolism and during administration of certain gut hormones .
7424693	0	calcium	71,78	parathyroid_hormone	25,44	calcium	parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY mediated|dobj|release mediated|nsubj|Effect Effect|nmod|sera sera|nmod|END_ENTITY	Effect of uremic sera on parathyroid_hormone -LRB- PTH -RRB- mediated release of calcium from normal rat embryonal bone maintained in tissue culture .
744047	0	calcium	68,75	parathyroid_hormone	11,30	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of parathyroid_hormone on the distribution and transport of calcium in cultured kidney cells .
744050	0	calcium	29,36	parathyroid_hormone	54,73	calcium	parathyroid hormone	MESH:D002118	280903(Tax:9913)	Chemical	Gene	effects|nmod|START_ENTITY Comparison|nmod|effects Comparison|nmod|rate rate|amod|END_ENTITY	Comparison of the effects of calcium and magnesium on parathyroid_hormone secretion rate in calves .
7479909	0	calcium	9,16	parathyroid_hormone	108,127	calcium	parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	transcripts|compound|START_ENTITY transcripts|dep|activation activation|acl|alpha alpha|nmod|END_ENTITY	Multiple calcium channel transcripts in rat_osteosarcoma cells : selective activation of alpha 1D isoform by parathyroid_hormone .
7525254	0	calcium	44,51	parathyroid_hormone	11,30	calcium	parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of parathyroid_hormone on cytosolic calcium of rat adipocytes .
7599930	0	calcium	20,27	parathyroid_hormone	97,116	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	release|compound|START_ENTITY triggered|nsubj|release triggered|nmod|receptor receptor|compound|END_ENTITY	Heparin-insensitive calcium release from intracellular stores triggered by the recombinant human parathyroid_hormone receptor .
7607615	0	calcium	35,42	parathyroid_hormone	73,92	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|immunoheterogeneity immunoheterogeneity|nmod|END_ENTITY	Effects of minor increase in serum calcium on the immunoheterogeneity of parathyroid_hormone in healthy subjects and in patients with primary_hyperparathyroidism .
7786039	0	calcium	20,27	parathyroid_hormone	102,121	calcium	parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY role|dep|induction induction|compound|END_ENTITY	The role of dietary calcium in the physiology of vitamin_D toxicity : excess dietary vitamin_D3 blunts parathyroid_hormone induction of kidney 1-hydroxylase .
7840323	0	calcium	48,55	parathyroid_hormone	19,38	calcium	parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	actions|nmod|START_ENTITY actions|nmod|END_ENTITY	Central actions of parathyroid_hormone on blood calcium and hypothalamic neuronal activity in the rat .
8148663	0	calcium	14,21	parathyroid_hormone	23,42	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	START_ENTITY|appos|variables variables|amod|END_ENTITY	Serum ionized calcium , parathyroid_hormone and related variables : effect of age and sex .
8149409	0	calcium	9,16	parathyroid_hormone	27,46	calcium	parathyroid hormone	MESH:D002118	280903(Tax:9913)	Chemical	Gene	influx|compound|START_ENTITY influx|nmod|END_ENTITY	Enhanced calcium influx by parathyroid_hormone in identified Helisoma trivolvis snail neurons .
8262476	0	calcium	15,22	parathyroid_hormone	49,68	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	Suppression|nmod|START_ENTITY END_ENTITY|nsubj|Suppression	Suppression by calcium of serum levels of intact parathyroid_hormone in patients with primary_hyperparathyroidism .
8287315	0	calcium	18,25	parathyroid_hormone	73,92	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	concentration|compound|START_ENTITY Decrease|nmod|concentration Decrease|nmod|release release|amod|END_ENTITY	Decrease of serum calcium concentration and lost influence of calcium on parathyroid_hormone release in a patient with primary_hyperparathyroidism after treatment with diphosphonates .
8287315	0	calcium	62,69	parathyroid_hormone	73,92	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	Decrease|nmod|START_ENTITY Decrease|nmod|release release|amod|END_ENTITY	Decrease of serum calcium concentration and lost influence of calcium on parathyroid_hormone release in a patient with primary_hyperparathyroidism after treatment with diphosphonates .
8289986	0	calcium	5,12	parathyroid_hormone	33,52	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|levels levels|amod|END_ENTITY	Oral calcium effectively reduces parathyroid_hormone levels in hemodialysis patients : a randomized double-blind placebo-controlled study .
8299139	0	calcium	31,38	parathyroid_hormone	52,71	calcium	parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	responses|compound|START_ENTITY responses|nmod|END_ENTITY	Heterogeneity of intracellular calcium responses to parathyroid_hormone and thrombin in primary osteoblast-like cells and UMR106-01 cells : correlations with culture conditions , intracellular calcium concentration and differentiation state .
8306196	0	calcium	57,64	parathyroid_hormone	18,37	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	current|compound|START_ENTITY modulation|nmod|current effects|dep|modulation effects|nmod|END_ENTITY	Neural effects of parathyroid_hormone : modulation of the calcium channel current and metabolism of monoamines in identified Helisoma snail neurons .
8338927	0	calcium	141,148	parathyroid_hormone	37,56	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	changes|nmod|START_ENTITY unrelated|nmod|changes %|acl:relcl|unrelated affects|nmod|% affects|dobj|levels levels|amod|END_ENTITY	Elevation of serum phosphate affects parathyroid_hormone levels in only 50 % of hemodialysis patients , which is unrelated to changes in serum calcium .
8466711	0	calcium	83,90	parathyroid_hormone	8,27	calcium	parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	loading|compound|START_ENTITY effect|nmod|loading reverses|dobj|effect reverses|nsubj|administration administration|compound|END_ENTITY	Chronic parathyroid_hormone administration reverses the antihypertensive effect of calcium loading in young spontaneously hypertensive rats .
8569602	0	calcium	10,17	parathyroid_hormone	62,81	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	Effect|nmod|START_ENTITY dihydroxyvitamin_D|nsubj|Effect dihydroxyvitamin_D|nmod|level level|nmod|END_ENTITY	Effect of calcium and 1,25 _ dihydroxyvitamin_D on the level of parathyroid_hormone in patients with secondary_hyperparathyroidism due to chronic_renal_insufficiency .
8586780	0	calcium	18,25	parathyroid_hormone	78,97	calcium	parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	Changes|nmod|START_ENTITY Changes|nmod|END_ENTITY	Changes in tissue calcium and phosphorus content and plasma concentrations of parathyroid_hormone and calcitonin after long-term magnesium deficiency in rats .
8734454	0	calcium	75,82	parathyroid_hormone	25,44	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	ions|compound|START_ENTITY ions|compound|END_ENTITY	Serpentine receptors for parathyroid_hormone , calcitonin and extracellular calcium ions .
8770972	0	calcium	17,24	parathyroid_hormone	46,65	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	point|nmod|START_ENTITY point|nmod|END_ENTITY	The set point of calcium and the reduction of parathyroid_hormone in hemodialysis patients .
879278	0	calcium	50,57	parathyroid_hormone	8,27	calcium	parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Role of parathyroid_hormone in regulation of main calcium fluxes in rats .
9038863	0	calcium	13,20	parathyroid_hormone	58,77	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|concentration concentration|nmod|END_ENTITY	Aging alters calcium regulation of serum concentration of parathyroid_hormone in healthy men .
9150477	0	calcium	22,29	parathyroid_hormone	33,52	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|release release|amod|END_ENTITY	Suppressive effect of calcium on parathyroid_hormone release in adynamic renal_osteodystrophy and secondary_hyperparathyroidism .
9164824	0	calcium	100,107	parathyroid_hormone	25,44	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	markers|nmod|START_ENTITY markers|nsubj|suppression suppression|nmod|resorption resorption|compound|END_ENTITY	Overnight suppression of parathyroid_hormone and bone resorption markers by active absorbable algae calcium .
9169348	0	calcium	55,62	parathyroid_hormone	22,41	calcium	parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|regulation regulation|nmod|END_ENTITY	Altered regulation of parathyroid_hormone secretion by calcium in pregnant and lactating rats .
9252978	0	calcium	168,175	parathyroid_hormone	70,89	calcium	parathyroid hormone	MESH:D002118	280903(Tax:9913)	Chemical	Gene	increase|nmod|START_ENTITY END_ENTITY|nmod|increase	Interaction between extracellular calcium and endothelin-1 influences parathyroid_hormone secretion from bovine parathyroid cells through the increase in intracellular calcium .
9252978	0	calcium	34,41	parathyroid_hormone	70,89	calcium	parathyroid hormone	MESH:D002118	280903(Tax:9913)	Chemical	Gene	Interaction|nmod|START_ENTITY END_ENTITY|nsubj|Interaction	Interaction between extracellular calcium and endothelin-1 influences parathyroid_hormone secretion from bovine parathyroid cells through the increase in intracellular calcium .
9279963	0	calcium	97,104	parathyroid_hormone	38,57	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|model model|nmod|END_ENTITY	A mathematical/physiological model of parathyroid_hormone secretion in response to blood-ionized calcium lowering in vivo .
9335387	0	calcium	80,87	parathyroid_hormone	132,151	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	dialysate|compound|START_ENTITY dialysate|dep|role role|nmod|level level|compound|END_ENTITY	Hypercalcemia during pulse vitamin_D3 therapy in CAPD patients treated with low calcium dialysate : the role of the decreasing serum parathyroid_hormone level .
9430621	0	calcium	9,16	parathyroid_hormone	42,61	calcium	parathyroid hormone	MESH:D002118	19226(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY isoforms|nsubj|channel isoforms|xcomp|mediate mediate|dobj|entry entry|amod|END_ENTITY	Distinct calcium channel isoforms mediate parathyroid_hormone and chlorothiazide-stimulated calcium entry in transporting epithelial cells .
9430621	0	calcium	92,99	parathyroid_hormone	42,61	calcium	parathyroid hormone	MESH:D002118	19226(Tax:10090)	Chemical	Gene	entry|compound|START_ENTITY entry|amod|END_ENTITY	Distinct calcium channel isoforms mediate parathyroid_hormone and chlorothiazide-stimulated calcium entry in transporting epithelial cells .
9459385	0	calcium	8,15	parathyroid_hormone	71,90	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	START_ENTITY|dep|effect effect|nmod|metabolites metabolites|amod|END_ENTITY	Dietary calcium and vitamin_D intake in elderly women : effect on serum parathyroid_hormone and vitamin_D metabolites .
9478982	0	calcium	98,105	parathyroid_hormone	59,78	calcium	parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	binding|nmod|START_ENTITY binding|nmod|expression expression|amod|END_ENTITY	RNA-Protein binding and post-transcriptional regulation of parathyroid_hormone gene expression by calcium and phosphate .
9495509	0	calcium	21,28	parathyroid_hormone	54,73	calcium	parathyroid hormone	MESH:D002118	5741	Chemical	Gene	supplementation|compound|START_ENTITY effects|nmod|supplementation END_ENTITY|nsubj|effects	Long-term effects of calcium supplementation on serum parathyroid_hormone level , bone turnover , and bone_loss in elderly women .
9784918	0	calcium	84,91	parathyroid_hormone	51,70	calcium	parathyroid hormone	MESH:D002118	24694(Tax:10116)	Chemical	Gene	impairs|nmod|START_ENTITY impairs|dobj|action action|nmod|END_ENTITY	Acute lithium administration impairs the action of parathyroid_hormone on rat renal calcium , magnesium and phosphate transport .
18096456	0	calcium	14,21	parathyroid_hormone-related_peptide	32,67	calcium	parathyroid hormone-related peptide	MESH:D002118	5744	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Extracellular calcium regulates parathyroid_hormone-related_peptide expression in osteoblasts and osteoblast progenitor cells .
2482098	0	calcium	75,82	parathyroid_hormone-related_peptide	21,56	calcium	parathyroid hormone-related peptide	MESH:D002118	5744	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of human parathyroid_hormone-related_peptide on cytosolic free calcium and cAMP production in opossum kidney cell .
8109185	0	calcium	84,91	parathyroid_hormone-related_peptide	30,65	calcium	parathyroid hormone-related peptide	MESH:D002118	5744	Chemical	Gene	maintenance|nmod|START_ENTITY END_ENTITY|nmod|maintenance	Possible compensatory role of parathyroid_hormone-related_peptide on maintenance of calcium homeostasis in patients with non-insulin-dependent_diabetes_mellitus .
8940360	0	calcium	68,75	parathyroid_hormone-related_peptide	12,47	calcium	parathyroid hormone-related peptide	MESH:D002118	5744	Chemical	Gene	mobilizes|dobj|START_ENTITY mobilizes|nsubj|END_ENTITY	A midregion parathyroid_hormone-related_peptide mobilizes cytosolic calcium and stimulates formation of inositol_trisphosphate in a squamous_carcinoma cell line .
9203999	0	calcium	183,190	parathyroid_hormone-related_peptide	53,88	calcium	parathyroid hormone-related peptide	MESH:D002118	5744	Chemical	Gene	Measurement|nmod|START_ENTITY Measurement|nmod|END_ENTITY	Measurement of N - and C-terminal-region fragments of parathyroid_hormone-related_peptide in milk from lactating women and investigation of the relationship of their concentrations to calcium in milk .
15930357	0	calcium	16,23	parathyroid_hormone-related_protein	40,75	calcium	parathyroid hormone-related protein	MESH:D002118	24695(Tax:10116)	Chemical	Gene	reabsorption|compound|START_ENTITY reabsorption|nmod|END_ENTITY	Increased renal calcium reabsorption by parathyroid_hormone-related_protein is a causative factor in the development of humoral_hypercalcemia_of_malignancy refractory to osteoclastic bone resorption inhibitors .
17172477	0	calcium	97,104	parathyroid_hormone-related_protein	25,60	calcium	parathyroid hormone-related protein	MESH:D002118	403987(Tax:9615)	Chemical	Gene	metabolism|compound|START_ENTITY concentrations|nmod|metabolism concentrations|nmod|END_ENTITY	Plasma concentrations of parathyroid_hormone-related_protein in dogs with potential disorders of calcium metabolism .
19915296	0	calcium	93,100	parathyroid_hormone-related_protein	37,72	calcium	parathyroid hormone-related protein	MESH:D002118	5744	Chemical	Gene	level|compound|START_ENTITY producing|nmod|level producing|dobj|END_ENTITY	Thyroid_follicular_adenoma producing parathyroid_hormone-related_protein with a normal serum calcium level .
2223059	0	calcium	44,51	parathyroid_hormone-related_protein	101,136	calcium	parathyroid hormone-related protein	MESH:D002118	5744	Chemical	Gene	transport|nmod|START_ENTITY Stimulation|nmod|transport Stimulation|nmod|END_ENTITY	Stimulation of ovine placental transport of calcium and magnesium by mid-molecule fragments of human parathyroid_hormone-related_protein .
2846659	0	calcium	62,69	parathyroid_hormone-related_protein	14,49	calcium	parathyroid hormone-related protein	MESH:D002118	5744	Chemical	Gene	due|nsubj|START_ENTITY lower|xcomp|due lower|nsubj|Antibodies Antibodies|nmod|END_ENTITY	Antibodies to parathyroid_hormone-related_protein lower serum calcium in athymic mouse models of malignancy-associated hypercalcemia due to human tumors .
3343349	0	calcium	110,117	parathyroid_hormone-related_protein	36,71	calcium	parathyroid hormone-related protein	MESH:D002118	5744	Chemical	Gene	reabsorption|compound|START_ENTITY reabsorption|amod|END_ENTITY	Effects of a synthetic peptide of a parathyroid_hormone-related_protein on calcium homeostasis , renal tubular calcium reabsorption , and bone metabolism in vivo and in vitro in rodents .
3343349	0	calcium	75,82	parathyroid_hormone-related_protein	36,71	calcium	parathyroid hormone-related protein	MESH:D002118	5744	Chemical	Gene	homeostasis|compound|START_ENTITY END_ENTITY|nmod|homeostasis	Effects of a synthetic peptide of a parathyroid_hormone-related_protein on calcium homeostasis , renal tubular calcium reabsorption , and bone metabolism in vivo and in vitro in rodents .
7778690	0	calcium	75,82	parathyroid_hormone-related_protein	14,49	calcium	parathyroid hormone-related protein	MESH:D002118	5744	Chemical	Gene	release|nmod|START_ENTITY release|amod|END_ENTITY	Inhibition of parathyroid_hormone-related_protein release by extracellular calcium in dispersed cells from human parathyroid_hyperplasia secondary to chronic_renal_failure and adenoma .
8467460	0	calcium	79,86	parathyroid_hormone-related_protein	21,56	calcium	parathyroid hormone-related protein	MESH:D002118	5744	Chemical	Gene	level|compound|START_ENTITY expression|nmod|level expression|nmod|END_ENTITY	Common expression of parathyroid_hormone-related_protein and no correlation of calcium level in renal_cell_carcinomas .
8938591	0	calcium	72,79	parathyroid_hormone-related_protein	18,53	calcium	parathyroid hormone-related protein	MESH:D002118	19227(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY role|nmod|transport role|nmod|END_ENTITY	The role of fetal parathyroid_hormone-related_protein in transplacental calcium transport .
9154918	0	calcium	26,33	parvalbumin	47,58	calcium	parvalbumin	MESH:D002118	5816	Chemical	Gene	release|compound|START_ENTITY release|nmod|END_ENTITY	Conformational effects of calcium release from parvalbumin : comparison of computational simulations with spectroscopic investigations .
1994494	0	calcium	15,22	peptide_YY	55,65	calcium	peptide YY	MESH:D002118	607156(Tax:9615)	Chemical	Gene	blockade|compound|START_ENTITY blockade|nmod|END_ENTITY	The effects of calcium and calcium channel blockade on peptide_YY and neuropeptide Y release .
22808235	0	calcium	26,33	peroxidase	108,118	calcium	peroxidase	MESH:D002118	1043789(Tax:160488)	Chemical	Gene	motif|compound|START_ENTITY Identification|nmod|motif based|nsubj|Identification based|nmod|domain domain|amod|END_ENTITY	Identification of a novel calcium binding motif based on the detection of sequence insertions in the animal peroxidase domain of bacterial proteins .
9442066	0	calcium	10,17	peroxidase	65,75	calcium	peroxidase	MESH:D002118	548137(Tax:4513)	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of calcium , other ions , and pH on the reactions of barley peroxidase with hydrogen_peroxide and fluoride .
19381068	0	calcium	100,107	phosphatidylinositol_3-kinase	63,92	calcium	phosphatidylinositol 3-kinase	MESH:D002118	298947(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Angiotensin_II-induced aortic ring constriction is mediated by phosphatidylinositol_3-kinase / L-type calcium channel signaling pathway .
9112404	0	calcium	89,96	phosphoinositidase_C	41,61	calcium	phosphoinositidase C	MESH:D002118	23236	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Oxytocin receptor-mediated activation of phosphoinositidase_C and elevation of cytosolic calcium in the gonadotrope-derived alphaT3-1 cell line .
15194708	0	calcium	69,76	phosphoinositide_3-kinase	134,159	calcium	phosphoinositide 3-kinase	MESH:D002118	298947(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|amod|END_ENTITY	LY-294002 -LSB- 2 - -LRB- 4-morpholinyl -RRB- -8 - phenyl-4H-1-benzopyran-4-one -RSB- affects calcium signaling in airway_smooth_muscle cells independently of phosphoinositide_3-kinase inhibition .
25656605	0	calcium	87,94	phospholemman	63,76	calcium	phospholemman	MESH:D002118	5348	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|nmod|channels	Impact of phosphomimetic and non-phosphorylatable mutations of phospholemman on L-type calcium channels gating in HEK 293T cells .
11310962	0	calcium	61,68	phospholipase_A2	17,33	calcium	phospholipase A2	MESH:D002118	151056	Chemical	Gene	influx|compound|START_ENTITY control|nmod|influx isoforms|nmod|control isoforms|nsubj|Participation Participation|nmod|END_ENTITY	Participation of phospholipase_A2 isoforms in the control of calcium influx into electrically non-excitable cells .
12460575	0	calcium	26,33	phospholipase_A2	118,134	calcium	phospholipase A2	MESH:D002118	104974671	Chemical	Gene	ion|compound|START_ENTITY Observation|nmod|ion Observation|nmod|M M|nmod|END_ENTITY	Observation of additional calcium ion in the crystal structure of the triple mutant K56 ,120,121 M of bovine pancreatic phospholipase_A2 .
1314702	0	calcium	34,41	phospholipase_A2	54,70	calcium	phospholipase A2	MESH:D002118	151056	Chemical	Gene	channels|compound|START_ENTITY activates|dobj|channels activates|nmod|production production|amod|END_ENTITY	Epidermal growth factor activates calcium channels by phospholipase_A2 / 5-lipoxygenase-mediated leukotriene_C4 production .
1449538	0	calcium	25,32	phospholipase_A2	87,103	calcium	phospholipase A2	MESH:D002118	151056	Chemical	Gene	Demonstration|nmod|START_ENTITY dependencies|nsubj|Demonstration dependencies|nmod|END_ENTITY	Demonstration of similar calcium dependencies by mammalian high and low molecular mass phospholipase_A2 .
15093616	0	calcium	118,125	phospholipase_A2	98,114	calcium	phospholipase A2	MESH:D002118	104974671	Chemical	Gene	ionophore|compound|START_ENTITY END_ENTITY|nmod|ionophore	Role of an aprotinin-sensitive protease in protein_kinase_Calpha-mediated activation of cytosolic phospholipase_A2 by calcium ionophore -LRB- A23187 -RRB- in pulmonary endothelium .
15993852	0	calcium	81,88	phospholipase_A2	25,41	calcium	phospholipase A2	MESH:D002118	151056	Chemical	Gene	entry|compound|START_ENTITY END_ENTITY|nmod|entry	Role of Ca2 + - independent phospholipase_A2 and cytochrome_P-450 in store-operated calcium entry in 3T6 fibroblasts .
16552140	0	calcium	6,13	phospholipase_A2	46,62	calcium	phospholipase A2	MESH:D002118	104974671	Chemical	Gene	ion|compound|START_ENTITY found|nsubj|ion found|nmod|END_ENTITY	Third calcium ion found in an inhibitor-bound phospholipase_A2 .
16790927	0	calcium	54,61	phospholipase_A2	171,187	calcium	phospholipase A2	MESH:D002118	104974671	Chemical	Gene	involvement|nmod|START_ENTITY evidence|nmod|involvement evidence|dep|structures structures|nmod|mutant mutant|nmod|END_ENTITY	Suggestive evidence for the involvement of the second calcium and surface loop in interfacial binding : monoclinic and trigonal crystal structures of a quadruple mutant of phospholipase_A2 .
1799439	0	calcium	16,23	phospholipase_A2	141,157	calcium	phospholipase A2	MESH:D002118	151056	Chemical	Gene	concentration|compound|START_ENTITY liposomes|nsubj|concentration liposomes|nmod|END_ENTITY	The interfacial calcium ion concentration as modulator of the latency phase in the hydrolysis of dimyristoylphosphatidylcholine liposomes by phospholipase_A2 .
2124620	0	calcium	96,103	phospholipase_A2	62,78	calcium	phospholipase A2	MESH:D002118	100764593	Chemical	Gene	influx|compound|START_ENTITY inducing|dobj|influx stimulates|advcl|inducing stimulates|dobj|END_ENTITY	A transfected m5 muscarinic acetylcholine receptor stimulates phospholipase_A2 by inducing both calcium influx and activation of protein_kinase_C .
2661228	0	calcium	72,79	phospholipase_A2	106,122	calcium	phospholipase A2	MESH:D002118	151056	Chemical	Gene	binding|nmod|START_ENTITY ion|amod|binding ion|nmod|END_ENTITY	Glutamic_acid_71 and aspartic_acid 66 control the binding of the second calcium ion in porcine pancreatic phospholipase_A2 .
3080024	0	calcium	81,88	phospholipase_A2	39,55	calcium	phospholipase A2	MESH:D002118	151056	Chemical	Gene	buffering|dobj|START_ENTITY Selective|advcl|buffering Selective|dobj|inhibition inhibition|nmod|END_ENTITY	Selective inhibition of human platelet phospholipase_A2 by buffering cytoplasmic calcium with the fluorescent indicator quin_2 .
3193045	0	calcium	113,120	phospholipase_A2	14,30	calcium	phospholipase A2	MESH:D002118	151056	Chemical	Gene	ions|compound|START_ENTITY modulation|nmod|ions Inhibition|dep|modulation Inhibition|nmod|isoenzymes isoenzymes|amod|END_ENTITY	Inhibition of phospholipase_A2 isoenzymes in human endometrium by mefenamic_acid and indomethacin : modulation by calcium ions .
3818568	0	calcium	56,63	phospholipase_A2	106,122	calcium	phospholipase A2	MESH:D002118	151056	Chemical	Gene	site|compound|START_ENTITY located|nmod|site residue|acl|located Identification|nmod|residue flavoviridis|nsubj|Identification flavoviridis|dobj|END_ENTITY	Identification of the tryptophan residue located in the calcium binding site of Trimeresurus flavoviridis phospholipase_A2 .
42441	0	calcium	73,80	phospholipase_A2	23,39	calcium	phospholipase A2	MESH:D002118	151056	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|activity activity|amod|END_ENTITY	Modulation of purified phospholipase_A2 activity from human platelets by calcium and indomethacin .
6520120	0	calcium	80,87	phospholipase_A2	41,57	calcium	phospholipase A2	MESH:D002118	104974671	Chemical	Gene	ion|compound|START_ENTITY flavoviridis|nmod|ion flavoviridis|dobj|END_ENTITY	Interaction of Trimeresurus flavoviridis phospholipase_A2 and its fragment with calcium ion .
6532436	0	calcium	80,87	phospholipase_A2	21,37	calcium	phospholipase A2	MESH:D002118	151056	Chemical	Gene	conditions|compound|START_ENTITY destabilization|nmod|conditions destabilization|nsubj|role role|nmod|END_ENTITY	The possible role of phospholipase_A2 in cardiac membrane destabilization under calcium overload conditions .
6847709	0	calcium	139,146	phospholipase_A2	15,31	calcium	phospholipase A2	MESH:D002118	104974671	Chemical	Gene	uptake|compound|START_ENTITY suppression|nmod|uptake cells|nmod|suppression Suppression|nmod|cells Suppression|nmod|inhibitors inhibitors|amod|END_ENTITY	Suppression by phospholipase_A2 inhibitors of secretion of catecholamines from isolated adrenal medullary cells by suppression of cellular calcium uptake .
7131592	0	calcium	30,37	phospholipase_A2	10,26	calcium	phospholipase A2	MESH:D002118	406141(Tax:7460)	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|nmod|transport	Effect of phospholipase_A2 on calcium transport in brain synaptosomes .
7601096	0	calcium	73,80	phospholipase_A2	95,111	calcium	phospholipase A2	MESH:D002118	100764593	Chemical	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	The guanine-nucleotide-binding protein subunit G alpha i2 is involved in calcium activation of phospholipase_A2 .
7675820	0	calcium	24,31	phospholipase_A2	117,133	calcium	phospholipase A2	MESH:D002118	151056	Chemical	Gene	Influx|nmod|START_ENTITY appear|nsubj|Influx appear|xcomp|essential essential|nmod|activation activation|nmod|END_ENTITY	Influx of extracellular calcium and agonist-coupling appear essential for the activation of thromboxane_A2-dependent phospholipase_A2 in human platelets .
7717193	0	calcium	22,29	phospholipase_A2	51,67	calcium	phospholipase A2	MESH:D002118	151056	Chemical	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Role of intracellular calcium in the regulation of phospholipase_A2 in fMet-Leu-Phe-challenged human polymorph neutrophils .
7969820	0	calcium	142,149	phospholipase_A2	47,63	calcium	phospholipase A2	MESH:D002118	151056	Chemical	Gene	channels|compound|START_ENTITY activation|nmod|channels stimulates|nmod|activation stimulates|dobj|END_ENTITY	The cloned vasopressin V1a receptor stimulates phospholipase_A2 , phospholipase C , and phospholipase D through activation of receptor-operated calcium channels .
827311	0	calcium	66,73	phospholipase_A2	14,30	calcium	phospholipase A2	MESH:D002118	151056	Chemical	Gene	ion|compound|START_ENTITY platelets|nmod|ion activity|nmod|platelets activity|amod|END_ENTITY	Initiation of phospholipase_A2 activity in human platelets by the calcium ion ionophore A23187 .
8418853	0	calcium	47,54	phospholipase_A2	71,87	calcium	phospholipase A2	MESH:D002118	151056	Chemical	Gene	ion|nsubj|START_ENTITY ion|xcomp|selective selective|nsubj|activity activity|amod|END_ENTITY	Rat and human pancreatic islet cells contain a calcium ion independent phospholipase_A2 activity selective for hydrolysis of arachidonate which is stimulated by adenosine_triphosphate and is specifically localized to islet beta-cells .
8446649	0	calcium	143,150	phospholipase_A2	125,141	calcium	phospholipase A2	MESH:D002118	151056	Chemical	Gene	availability|amod|START_ENTITY availability|amod|END_ENTITY	Prostaglandin_F2_alpha synthesis in the hippocampal mossy fiber synaptosomal preparation : I. Dependence in arachidonic_acid , phospholipase_A2 , calcium availability and membrane depolarization .
8526939	0	calcium	124,131	phospholipase_A2	14,30	calcium	phospholipase A2	MESH:D002118	151056	Chemical	Gene	influx|compound|START_ENTITY involves|dobj|influx involves|nsubj|Activation Activation|nmod|cells cells|amod|END_ENTITY	Activation of phospholipase_A2 by the human endothelin receptor in Chinese_hamster ovary cells involves Gi protein-mediated calcium influx .
8093016	0	calcium	115,122	phospholipase_C_gamma_2	52,75	calcium	phospholipase C gamma 2	MESH:D002118	5336	Chemical	Gene	mobilization|compound|START_ENTITY END_ENTITY|nmod|mobilization	Evidence for a role for tyrosine phosphorylation of phospholipase_C_gamma_2 in collagen-induced platelet cytosolic calcium mobilization .
22456923	0	calcium	63,70	phospholipase_C_zeta_1	18,40	calcium	phospholipase C zeta 1	MESH:D002118	89869	Chemical	Gene	oscillations|compound|START_ENTITY induces|dobj|oscillations induces|nsubj|END_ENTITY	Recombinant human phospholipase_C_zeta_1 induces intracellular calcium oscillations and oocyte activation in mouse and human oocytes .
10940387	0	calcium	49,56	phospholipase_D	15,30	calcium	phospholipase D	MESH:D002118	2822	Chemical	Gene	influx|compound|START_ENTITY END_ENTITY|nmod|influx	Involvement of phospholipase_D in store-operated calcium influx in vascular smooth muscle cells .
11092463	0	calcium	79,86	phospholipase_D	98,113	calcium	phospholipase D	MESH:D002118	2822	Chemical	Gene	activation|compound|START_ENTITY activation|amod|END_ENTITY	Defective platelet_aggregation in polycythaemia_vera is not caused by impaired calcium signaling , phospholipase_D activation or decreased amounts of focal adhesion proteins .
11940565	0	calcium	8,15	phospholipase_D	45,60	calcium	phospholipase D	MESH:D002118	2822	Chemical	Gene	organization|compound|START_ENTITY Role|nmod|organization Role|nmod|localization localization|amod|END_ENTITY	Role of calcium and membrane organization on phospholipase_D localization and activity .
12067705	0	calcium	11,18	phospholipase_D	54,69	calcium	phospholipase D	MESH:D002118	2822	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	A role for calcium in sphingosine_1-phosphate-induced phospholipase_D activity in C2C12 myoblasts .
1419487	0	calcium	120,127	phospholipase_D	56,71	calcium	phospholipase D	MESH:D002118	2822	Chemical	Gene	role|nmod|START_ENTITY vitro|dep|role kinases|amod|vitro END_ENTITY|nmod|kinases	Granulocyte-macrophage_colony-stimulating_factor primes phospholipase_D activity in human neutrophils in vitro : role of calcium , G-proteins and tyrosine kinases .
24643913	0	calcium	31,38	phospholipase_D	78,93	calcium	phospholipase D	MESH:D002118	2822	Chemical	Gene	ions|compound|START_ENTITY substitutes|nmod|ions Lanthanides|nmod|substitutes END_ENTITY|nsubj|Lanthanides	Lanthanides as substitutes for calcium ions in the activation of plant a-type phospholipase_D .
11007307	0	calcium	13,20	pituitary_adenylate_cyclase-activating_polypeptide	38,88	calcium	pituitary adenylate cyclase-activating polypeptide	MESH:D002118	24166(Tax:10116)	Chemical	Gene	responses|compound|START_ENTITY responses|nmod|END_ENTITY	Differential calcium responses to the pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- in the five main cell types of rat anterior pituitary .
2433881	0	calcium	13,20	placental_lactogen	54,72	calcium	placental lactogen	MESH:D002118	1443	Chemical	Gene	ion|compound|START_ENTITY ion|nmod|END_ENTITY	Interrelated calcium ion and cyclic_AMP inhibition of placental_lactogen secretion by cultured human term trophoblast .
6786106	0	calcium	66,73	placental_lactogen	6,24	calcium	placental lactogen	MESH:D002118	1443	Chemical	Gene	effects|nmod|START_ENTITY release|dep|effects release|compound|END_ENTITY	Human placental_lactogen release in vitro : paradoxical effects of calcium .
7684340	0	calcium	82,89	placental_lactogen	18,36	calcium	placental lactogen	MESH:D002118	1443	Chemical	Gene	role|nmod|START_ENTITY modulation|dep|role modulation|nmod|release release|compound|END_ENTITY	The modulation of placental_lactogen release by opioids : a role for extracellular calcium .
7690361	0	calcium	25,32	placental_lactogen	54,72	calcium	placental lactogen	MESH:D002118	1443	Chemical	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	A role for extracellular calcium in the regulation of placental_lactogen release by angiotensin-II and dopamine in human term trophoblastic cells .
20880258	0	calcium	45,52	plasma_membrane_calcium_ATPase	4,34	calcium	plasma membrane calcium ATPase	MESH:D002118	67972(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY modulates|dobj|homeostasis modulates|nsubj|END_ENTITY	The plasma_membrane_calcium_ATPase modulates calcium homeostasis , intracellular signaling events and function in platelets .
9368000	0	calcium	43,50	pp60c-src	12,21	calcium	pp60c-src	MESH:D002118	20779(Tax:10090)	Chemical	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	The role of pp60c-src in the regulation of calcium entry via store-operated calcium channels .
9368000	0	calcium	76,83	pp60c-src	12,21	calcium	pp60c-src	MESH:D002118	20779(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY role|nmod|channels role|nmod|entry entry|amod|END_ENTITY	The role of pp60c-src in the regulation of calcium entry via store-operated calcium channels .
14622132	0	calcium	35,42	prion_protein	67,80	calcium	prion protein	MESH:D002118	19122(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY Modulation|nmod|channels Modulation|nmod|END_ENTITY	Modulation of L-type voltage-gated calcium channels by recombinant prion_protein .
15788568	0	calcium	50,57	prion_protein	4,17	calcium	prion protein	MESH:D002118	100762792	Chemical	Gene	affect|dobj|START_ENTITY affect|nsubj|END_ENTITY	The prion_protein and its paralogue Doppel affect calcium signaling in Chinese_hamster ovary cells .
17241158	0	calcium	51,58	prion_protein	9,22	calcium	prion protein	MESH:D002118	5621	Chemical	Gene	response|compound|START_ENTITY modulates|dobj|response modulates|nsubj|END_ENTITY	Cellular prion_protein modulates the intracellular calcium response to hydrogen_peroxide .
24329154	0	calcium	43,50	prion_protein	63,76	calcium	prion protein	MESH:D002118	5621	Chemical	Gene	channels|compound|START_ENTITY channels|nmod|END_ENTITY	The inhibition of functional expression of calcium channels by prion_protein demonstrates competition with a2 for GPI-anchoring pathways .
10729100	0	calcium	45,52	prolactin	11,20	calcium	prolactin	MESH:D002118	280901(Tax:9913)	Chemical	Gene	stored|dobj|START_ENTITY stored|nsubj|Effects Effects|nmod|END_ENTITY	Effects of prolactin on intracellular stored calcium in the course of bovine oocyte maturation in vitro .
11968058	0	calcium	38,45	prolactin	11,20	calcium	prolactin	MESH:D002118	5617	Chemical	Gene	concentration|compound|START_ENTITY Effects|nmod|concentration Effects|nmod|END_ENTITY	Effects of prolactin on intracellular calcium concentration and cell proliferation in human glioma cells .
1280232	0	calcium	66,73	prolactin	19,28	calcium	prolactin	MESH:D002118	24683(Tax:10116)	Chemical	Gene	influx|compound|START_ENTITY blocking|dobj|influx inhibits|advcl|blocking inhibits|dobj|secretion secretion|compound|END_ENTITY	Lidocaine inhibits prolactin secretion in GH4C1 cells by blocking calcium influx .
12810546	0	calcium	89,96	prolactin	22,31	calcium	prolactin	MESH:D002118	5617	Chemical	Gene	influx|compound|START_ENTITY downstream|nmod|influx inhibits|nmod|downstream inhibits|dobj|secretion secretion|compound|END_ENTITY	Nitric_oxide inhibits prolactin secretion in pituitary cells downstream of voltage-gated calcium influx .
1332473	0	calcium	11,18	prolactin	58,67	calcium	prolactin	MESH:D002118	5617	Chemical	Gene	blockade|compound|START_ENTITY blockade|nmod|responses responses|amod|verapamil verapamil|nmod|END_ENTITY	Effects of calcium channel blockade with verapamil on the prolactin responses to TRH , L-dopa , and bromocriptine .
1407368	0	calcium	105,112	prolactin	51,60	calcium	prolactin	MESH:D002118	24683(Tax:10116)	Chemical	Gene	increase|nmod|START_ENTITY END_ENTITY|nmod|increase	Diencephalic GABAergic neurons in vitro respond to prolactin with a rapid increase in intracellular free calcium .
1597150	0	calcium	18,25	prolactin	78,87	calcium	prolactin	MESH:D002118	5617	Chemical	Gene	current|compound|START_ENTITY current|nmod|secretion secretion|compound|END_ENTITY	Voltage-dependent calcium current in human decidual cells and its relation to prolactin secretion .
16091785	0	calcium	35,42	prolactin	11,20	calcium	prolactin	MESH:D002118	24683(Tax:10116)	Chemical	Gene	absorption|compound|START_ENTITY modulated|dobj|absorption modulated|nsubj|END_ENTITY	Endogenous prolactin modulated the calcium absorption in the jejunum of suckling rats .
16339748	0	calcium	98,105	prolactin	10,19	calcium	prolactin	MESH:D002118	24683(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY stimulated|dobj|transport stimulated|nsubj|exposure exposure|compound|END_ENTITY	Long-term prolactin exposure differentially stimulated the transcellular and solvent drag-induced calcium transport in the duodenum of ovariectomized rats .
1703275	0	calcium	10,17	prolactin	55,64	calcium	prolactin	MESH:D002118	24683(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY channel|dep|modulation modulation|nmod|expression expression|amod|END_ENTITY	Pituitary calcium channel modulation and regulation of prolactin gene expression .
1779976	0	calcium	31,38	prolactin	59,68	calcium	prolactin	MESH:D002118	5617	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Pit-1 binding sequences permit calcium regulation of human prolactin gene expression .
1930208	0	calcium	102,109	prolactin	42,51	calcium	prolactin	MESH:D002118	24683(Tax:10116)	Chemical	Gene	influx|compound|START_ENTITY causing|dobj|influx regulate|advcl|causing regulate|dobj|secretion secretion|compound|END_ENTITY	Evidence that potassium channels regulate prolactin secretion in GH4C1 cells by causing extracellular calcium influx .
2055443	0	calcium	53,60	prolactin	15,24	calcium	prolactin	MESH:D002118	5617	Chemical	Gene	levels|compound|START_ENTITY regulation|nmod|levels Involvement|nmod|regulation Involvement|nmod|END_ENTITY	Involvement of prolactin in the regulation of plasma calcium levels in the newt , Cynops pyrrhogaster .
2123447	0	calcium	107,114	prolactin	30,39	calcium	prolactin	MESH:D002118	24683(Tax:10116)	Chemical	Gene	influx|compound|START_ENTITY producing|nmod|influx induces|advcl|producing induces|dobj|secretion secretion|compound|END_ENTITY	Evidence that ethanol induces prolactin secretion in GH4C1 cells by producing cell swelling with resultant calcium influx .
2268737	0	calcium	44,51	prolactin	16,25	calcium	prolactin	MESH:D002118	24683(Tax:10116)	Chemical	Gene	absorption|compound|START_ENTITY effect|nmod|absorption effect|nmod|END_ENTITY	Acute effect of prolactin on the intestinal calcium absorption in normal , pregnant and lactating rats .
22814336	0	calcium	25,32	prolactin	46,55	calcium	prolactin	MESH:D002118	24683(Tax:10116)	Chemical	Gene	Regulation|nmod|START_ENTITY transport|nsubj|Regulation transport|nmod|END_ENTITY	Regulation of epithelial calcium transport by prolactin : from fish to mammals .
2300047	0	calcium	80,87	prolactin	62,71	calcium	prolactin	MESH:D002118	24683(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|gene gene|compound|END_ENTITY	Transcriptional and posttranscriptional regulation of the rat prolactin gene by calcium .
2388520	0	calcium	38,45	prolactin	74,83	calcium	prolactin	MESH:D002118	24683(Tax:10116)	Chemical	Gene	stimulation|nmod|START_ENTITY uptake|nsubj|stimulation uptake|nmod|END_ENTITY	Age - and sex-dependent stimulation of calcium uptake in duodenal cells by prolactin in vitamin_D-deficient rats .
2446857	0	calcium	21,28	prolactin	50,59	calcium	prolactin	MESH:D002118	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|regulation regulation|nmod|gene gene|compound|END_ENTITY	Preferential role of calcium in the regulation of prolactin gene transcription by thyrotropin-releasing_hormone in GH3 pituitary cells .
2461851	0	calcium	26,33	prolactin	62,71	calcium	prolactin	MESH:D002118	24683(Tax:10116)	Chemical	Gene	activity|compound|START_ENTITY activity|acl|related related|xcomp|END_ENTITY	Dihydropyridine-sensitive calcium channel activity related to prolactin , growth_hormone , and luteinizing hormone release from anterior pituitary cells in culture : interactions with somatostatin , dopamine , and estrogens .
2464750	0	calcium	44,51	prolactin	74,83	calcium	prolactin	MESH:D002118	24683(Tax:10116)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|gene gene|compound|END_ENTITY	Proximal upstream flanking sequences direct calcium regulation of the rat prolactin gene .
2985726	0	calcium	102,109	prolactin	25,34	calcium	prolactin	MESH:D002118	5617	Chemical	Gene	effects|nmod|START_ENTITY vitro|dep|effects incubated|xcomp|vitro incubated|nsubj|Mechanisms Mechanisms|nmod|release release|nmod|END_ENTITY	Mechanisms of release of prolactin from fowl anterior pituitary glands incubated in vitro : effects of calcium and cyclic_adenosine_monophosphate .
3096691	0	calcium	146,153	prolactin	45,54	calcium	prolactin	MESH:D002118	24683(Tax:10116)	Chemical	Gene	elevation|nmod|START_ENTITY regulated|nmod|elevation synergistically|dep|regulated synergistically|nsubj|stimulation stimulation|nmod|secretion secretion|compound|END_ENTITY	Thyrotropin-releasing_hormone stimulation of prolactin secretion is coordinately but not synergistically regulated by an elevation of cytoplasmic calcium and 1,2-diacylglycerol .
3683076	0	calcium	18,25	prolactin	54,63	calcium	prolactin	MESH:D002118	24683(Tax:10116)	Chemical	Gene	antagonist|compound|START_ENTITY inhibits|nsubj|antagonist inhibits|dobj|expression expression|compound|END_ENTITY	The intracellular calcium antagonist , TMB-8 , inhibits prolactin gene expression in GH3 cells .
3922988	0	calcium	14,21	prolactin	25,34	calcium	prolactin	MESH:D002118	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|mRNA mRNA|compound|END_ENTITY	Regulation by calcium of prolactin and growth_hormone mRNA sequences in primary cultures of rat pituitary cells .
6194977	0	calcium	14,21	prolactin	53,62	calcium	prolactin	MESH:D002118	5617	Chemical	Gene	concentration|compound|START_ENTITY required|nsubj|concentration required|nmod|END_ENTITY	Extracellular calcium ion concentration required for prolactin to express its actions on casein , ribonucleic_acid , and lipid biosynthesis in mouse mammary gland explants .
6206370	0	calcium	33,40	prolactin	90,99	calcium	prolactin	MESH:D002118	24683(Tax:10116)	Chemical	Gene	involvement|nmod|START_ENTITY involvement|nmod|secretion secretion|compound|END_ENTITY	The possible involvement of both calcium and cyclic_AMP in the dopaminergic inhibition of prolactin secretion .
6243383	0	calcium	103,110	prolactin	23,32	calcium	prolactin	MESH:D002118	5617	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|levels levels|compound|END_ENTITY	The effect of elevated prolactin levels on plasma 1,25-dihydroxyvitamin _ D and intestinal absorption of calcium .
6323146	0	calcium	14,21	prolactin	68,77	calcium	prolactin	MESH:D002118	24683(Tax:10116)	Chemical	Gene	requirements|compound|START_ENTITY requirements|nmod|release release|nmod|END_ENTITY	Difference in calcium requirements for forskolin-induced release of prolactin from normal pituitary cells and GH4C1 cells in culture .
6403530	0	calcium	88,95	prolactin	108,117	calcium	prolactin	MESH:D002118	24683(Tax:10116)	Chemical	Gene	synergistically|nmod|START_ENTITY synergistically|acl|regulate regulate|dobj|levels levels|amod|END_ENTITY	Epidermal_growth_factor and thyrotropin-releasing_hormone interact synergistically with calcium to regulate prolactin mRNA levels .
6726108	0	calcium	103,110	prolactin	65,74	calcium	prolactin	MESH:D002118	5617	Chemical	Gene	studies|nmod|START_ENTITY investigation|dep|studies investigation|nmod|involvement involvement|nmod|calcium calcium|nmod|control control|nmod|secretion secretion|compound|END_ENTITY	An investigation of the involvement of calcium in the control of prolactin secretion : studies with low calcium , methoxyverapamil , cobalt and manganese .
6726108	0	calcium	39,46	prolactin	65,74	calcium	prolactin	MESH:D002118	5617	Chemical	Gene	START_ENTITY|nmod|control control|nmod|secretion secretion|compound|END_ENTITY	An investigation of the involvement of calcium in the control of prolactin secretion : studies with low calcium , methoxyverapamil , cobalt and manganese .
6787084	0	calcium	145,152	prolactin	45,54	calcium	prolactin	MESH:D002118	24683(Tax:10116)	Chemical	Gene	action|nmod|START_ENTITY evidence|nmod|action stimulation|dep|evidence stimulation|nmod|release release|compound|END_ENTITY	Thyrotropin-releasing_hormone stimulation of prolactin release from clonal rat pituitary cells : evidence for action independent of extracellular calcium .
6787929	0	calcium	8,15	prolactin	47,56	calcium	prolactin	MESH:D002118	24683(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY stimulated|nsubj|Role stimulated|dobj|release release|nmod|END_ENTITY	Role of calcium in acute stimulated release of prolactin from neoplastic GH3 cells .
6818058	0	calcium	15,22	prolactin	54,63	calcium	prolactin	MESH:D002118	443317(Tax:9940)	Chemical	Gene	Involvement|nmod|START_ENTITY ions|nsubj|Involvement ions|nmod|inhibition inhibition|nmod|secretion secretion|compound|END_ENTITY	Involvement of calcium ions in dopamine inhibition of prolactin secretion from sheep pituitary cells .
7293666	0	calcium	21,28	prolactin	38,47	calcium	prolactin	MESH:D002118	5617	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Inhibitory effect of calcium on serum prolactin .
7302575	0	calcium	26,33	prolactin	77,86	calcium	prolactin	MESH:D002118	24683(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY Stimulation|nmod|transport mobilization|nsubj|Stimulation mobilization|nmod|END_ENTITY	Stimulation of intestinal calcium transport and bone calcium mobilization by prolactin in vitamin_D-deficient rats .
7341767	0	calcium	30,37	prolactin	53,62	calcium	prolactin	MESH:D002118	5617	Chemical	Gene	load|compound|START_ENTITY effect|nmod|load -LSB-|dobj|effect -LSB-|nmod|END_ENTITY	-LSB- The effect of an intravenous calcium load on plasma prolactin in man -LRB- author 's transl -RRB- -RSB- .
7456395	0	calcium	9,16	prolactin	45,54	calcium	prolactin	MESH:D002118	24683(Tax:10116)	Chemical	Gene	START_ENTITY|acl|regulating regulating|dobj|release release|compound|END_ENTITY	-LSB- Role of calcium and potassium in regulating prolactin and somatotropic hormone release in cell cultures of rat adenohypophysis -RSB- .
7736343	0	calcium	65,72	prolactin	27,36	calcium	prolactin	MESH:D002118	24683(Tax:10116)	Chemical	Gene	distribution|nmod|START_ENTITY Studies|nmod|distribution Studies|nmod|effect effect|nmod|END_ENTITY	Studies of acute effect of prolactin on distribution of absorbed calcium and long-term effect on calcium balance in weaned , young , and sexually mature rats .
7736343	2	calcium	550,557	prolactin	498,507	calcium	prolactin	MESH:D002118	24683(Tax:10116)	Chemical	Gene	distribution|nmod|START_ENTITY affect|dobj|distribution failed|xcomp|affect failed|nsubj|administration administration|nmod|END_ENTITY	The acute administration of prolactin failed to affect distribution of absorbed calcium at 2 h after instillation of test solution .
7789747	0	calcium	58,65	prolactin	11,20	calcium	prolactin	MESH:D002118	5617	Chemical	Gene	levels|compound|START_ENTITY extract|nmod|levels extract|nsubj|Effects Effects|nmod|END_ENTITY	Effects of prolactin and fish pituitary extract on plasma calcium levels in common_carp , Cyprinus_carpio .
7977732	0	calcium	65,72	prolactin	15,24	calcium	prolactin	MESH:D002118	24683(Tax:10116)	Chemical	Gene	influx|compound|START_ENTITY role|nmod|influx Stimulation|dep|role Stimulation|nmod|release release|compound|END_ENTITY	Stimulation of prolactin release by dopamine withdrawal : role of calcium influx .
8148670	0	calcium	73,80	prolactin	40,49	calcium	prolactin	MESH:D002118	24683(Tax:10116)	Chemical	Gene	absorption|compound|START_ENTITY effect|nmod|absorption effect|nmod|END_ENTITY	Acute effect and mechanism of action of prolactin on the in situ passive calcium absorption in rat .
8388615	0	calcium	175,182	prolactin	39,48	calcium	prolactin	MESH:D002118	24683(Tax:10116)	Chemical	Gene	concentration|nmod|START_ENTITY increasing|dobj|concentration stimulates|advcl|increasing stimulates|dobj|synthesis synthesis|amod|END_ENTITY	Epidermal_growth_factor stimulates the prolactin synthesis and secretion in rat pituitary cells in culture -LRB- GH4C1 cells -RRB- by increasing the intracellular concentration of free calcium .
8564887	0	calcium	36,43	prolactin	16,25	calcium	prolactin	MESH:D002118	24683(Tax:10116)	Chemical	Gene	absorption|compound|START_ENTITY effect|nmod|absorption effect|nmod|END_ENTITY	Acute effect of prolactin on active calcium absorption in rats .
8852276	0	calcium	17,24	prolactin	43,52	calcium	prolactin	MESH:D002118	5617	Chemical	Gene	infusion|compound|START_ENTITY influence|nmod|infusion influence|nmod|END_ENTITY	The influence of calcium infusion on serum prolactin in hyperprolactinemic women .
9635163	0	calcium	76,83	prolactin	45,54	calcium	prolactin	MESH:D002118	24683(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY regulation|nmod|metabolism study|nmod|regulation study|nmod|significance significance|nmod|END_ENTITY	The study of a physiological significance of prolactin in the regulation of calcium metabolism during pregnancy and lactation in rats .
7873521	0	calcium	11,18	protein_C	78,87	calcium	protein C	MESH:D002118	5624	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of calcium to individual gamma-carboxyglutamic_acid residues of human protein_C .
3421328	0	calcium	11,18	protein_I	83,92	calcium	protein I	MESH:D002118	282689(Tax:9913)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of calcium on synthesis and secretion of parathyroid_hormone and secretory protein_I .
22513473	0	calcium	60,67	protein_kinase_C	16,32	calcium	protein kinase C	MESH:D002118	24681(Tax:10116)	Chemical	Gene	sensitivity|compound|START_ENTITY enhancement|nmod|sensitivity END_ENTITY|nmod|enhancement	-LSB- Involvement of protein_kinase_C in enhancement of vascular calcium sensitivity by blocking mesenteric lymph return in hemorrhagic_shock rats -RSB- .
24440668	0	calcium	72,79	protein_kinase_C	32,48	calcium	protein kinase C	MESH:D002118	112476	Chemical	Gene	signalling|compound|START_ENTITY roles|nmod|signalling Regulation|dep|roles Regulation|nmod|chondrogenesis chondrogenesis|nmod|END_ENTITY	Regulation of chondrogenesis by protein_kinase_C : Emerging new roles in calcium signalling .
19373133	0	calcium	142,149	protein_kinase_C-alpha	81,103	calcium	protein kinase C-alpha	MESH:D002118	24680(Tax:10116)	Chemical	Gene	sensitivity|compound|START_ENTITY sensitivity|amod|END_ENTITY	Involvement of Cpi-17 and zipper-interacting protein kinase in the regulation of protein_kinase_C-alpha , protein_kinase_C-epsilon on vascular calcium sensitivity after hemorrhagic_shock .
19373133	0	calcium	142,149	protein_kinase_C-epsilon	105,129	calcium	protein kinase C-epsilon	MESH:D002118	29340(Tax:10116)	Chemical	Gene	sensitivity|compound|START_ENTITY sensitivity|amod|END_ENTITY	Involvement of Cpi-17 and zipper-interacting protein kinase in the regulation of protein_kinase_C-alpha , protein_kinase_C-epsilon on vascular calcium sensitivity after hemorrhagic_shock .
8429022	0	calcium	15,22	protein_kinase_C_alpha	68,90	calcium	protein kinase C alpha	MESH:D002118	282001(Tax:9913)	Chemical	Gene	Stimulation|nmod|START_ENTITY uptake|nsubj|Stimulation uptake|nmod|END_ENTITY	Stimulation of calcium uptake in Saccharomyces_cerevisiae by bovine protein_kinase_C_alpha .
26171977	0	calcium	24,31	regucalcin	35,45	calcium	regucalcin	MESH:D002118	9104	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of extracellular calcium on regucalcin expression and cell viability in neoplastic and non-neoplastic human prostate cells .
1000779	0	calcium	29,36	renin	40,45	calcium	renin	MESH:D002118	403838(Tax:9615)	Chemical	Gene	site|nmod|START_ENTITY site|nmod|secretion secretion|compound|END_ENTITY	Intrarenal site of action of calcium on renin secretion in dogs .
1002819	0	calcium	31,38	renin	14,19	calcium	renin	MESH:D002118	5972	Chemical	Gene	ions|compound|START_ENTITY release|nmod|ions release|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of renin release by calcium and ammonium ions in normal man .
10619585	0	calcium	30,37	renin	49,54	calcium	renin	MESH:D002118	5972	Chemical	Gene	Modification|nmod|START_ENTITY END_ENTITY|nsubj|Modification	Modification of intracellular calcium and plasma renin by dietary calcium in men .
10894799	0	calcium	15,22	renin	39,44	calcium	renin	MESH:D002118	24715(Tax:10116)	Chemical	Gene	influx|compound|START_ENTITY inhibits|nsubj|influx inhibits|dobj|secretion secretion|compound|END_ENTITY	Store-operated calcium influx inhibits renin secretion .
1248206	0	calcium	30,37	renin	86,91	calcium	renin	MESH:D002118	5972	Chemical	Gene	administration|compound|START_ENTITY administration|nmod|activity activity|compound|END_ENTITY	Absence of an acute effect of calcium or parathyroid hormone administration on plasma renin activity in man .
12569263	0	calcium	84,91	renin	42,47	calcium	renin	MESH:D002118	5972	Chemical	Gene	transcription|nmod|START_ENTITY transcription|nsubj|Implication Implication|nmod|Ref-1 Ref-1|nmod|repression repression|nmod|gene gene|compound|END_ENTITY	Implication of Ref-1 in the repression of renin gene transcription by intracellular calcium .
1382264	0	calcium	21,28	renin	72,77	calcium	renin	MESH:D002118	24715(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY effects|nmod|channel blockers|nsubj|effects blockers|nmod|dependence dependence|nmod|secretion secretion|compound|END_ENTITY	Disparate effects of calcium channel blockers on pressure dependence of renin secretion and flow in the isolated perfused rat kidney .
15457	0	calcium	11,18	renin	22,27	calcium	renin	MESH:D002118	24715(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of calcium on renin and aldosterone in the rat .
19640903	0	calcium	12,19	renin	41,46	calcium	renin	MESH:D002118	5972	Chemical	Gene	role|nmod|START_ENTITY role|nmod|regulation regulation|nmod|secretion secretion|compound|END_ENTITY	The role of calcium in the regulation of renin secretion .
2006991	0	calcium	25,32	renin	82,87	calcium	renin	MESH:D002118	5972	Chemical	Gene	correlations|compound|START_ENTITY ionized|dobj|correlations ionized|nmod|adults adults|amod|END_ENTITY	Different plasma ionized calcium correlations with blood pressure in high and low renin normotensive adults in Utah .
20371952	0	calcium	81,88	renin	7,12	calcium	renin	MESH:D002118	5972	Chemical	Gene	antagonist|compound|START_ENTITY altered|nmod|antagonist altered|nsubjpass|activity activity|compound|END_ENTITY	Plasma renin activity and aldosterone concentration are not altered by the novel calcium channel antagonist , azelnidipine , in hypertensive patients .
2100527	0	calcium	62,69	renin	37,42	calcium	renin	MESH:D002118	5972	Chemical	Gene	nifedipine|compound|START_ENTITY comparison|nmod|nifedipine END_ENTITY|dep|comparison	-LSB- Arterial hypertension caused by low renin : comparison of the calcium antagonist nifedipine and the ACE-inhibitor enalapril as to antihypertensive efficacy -RSB- .
2140943	0	calcium	4,11	renin	85,90	calcium	renin	MESH:D002118	5972	Chemical	Gene	isradipine|compound|START_ENTITY related|nsubj|isradipine related|nmod|activity activity|compound|END_ENTITY	The calcium antagonist isradipine and its effect on blood pressure related to plasma renin activity .
2184050	0	calcium	93,100	renin	55,60	calcium	renin	MESH:D002118	24715(Tax:10116)	Chemical	Gene	levels|nmod|START_ENTITY activity|appos|levels activity|compound|END_ENTITY	-LSB- The effect of fenigidin -LRB- nifedipine -RRB- and verapamil on renin activity , the levels of ionized calcium and aldosterone in the blood plasma and on the hemodynamic indices of rats with spontaneous hypertension -RSB- .
2217270	0	calcium	50,57	renin	33,38	calcium	renin	MESH:D002118	24715(Tax:10116)	Chemical	Gene	deprivation|compound|START_ENTITY release|nmod|deprivation release|nsubj|rhythm rhythm|nmod|response response|nmod|END_ENTITY	Circannual rhythm in response of renin release to calcium deprivation in isolated rat glomeruli .
22538344	0	calcium	49,56	renin	77,82	calcium	renin	MESH:D002118	5972	Chemical	Gene	influence|nmod|START_ENTITY influence|nmod|secretion secretion|nmod|END_ENTITY	The influence of extracellular and intracellular calcium on the secretion of renin .
2404858	0	calcium	43,50	renin	15,20	calcium	renin	MESH:D002118	403838(Tax:9615)	Chemical	Gene	infusion|compound|START_ENTITY release|nmod|infusion release|nsubj|Stimulation Stimulation|nmod|END_ENTITY	Stimulation of renin release by intrarenal calcium infusion .
2416580	0	calcium	4,11	renin	50,55	calcium	renin	MESH:D002118	24715(Tax:10116)	Chemical	Gene	agonist|compound|START_ENTITY inhibits|nsubj|agonist inhibits|dobj|release release|compound|END_ENTITY	The calcium channel agonist , Bay_K_8644 , inhibits renin release from rat kidney cortical slices .
2433720	0	calcium	13,20	renin	40,45	calcium	renin	MESH:D002118	24715(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY Effects|nmod|channel agonist|nsubj|Effects agonist|nmod|release release|compound|END_ENTITY	Effects of a calcium channel agonist on renin release from perfused rat kidneys .
2437873	0	calcium	14,21	renin	48,53	calcium	renin	MESH:D002118	24715(Tax:10116)	Chemical	Gene	agonist|compound|START_ENTITY BAY_K_8644|appos|agonist inhibits|nsubj|BAY_K_8644 inhibits|dobj|secretion secretion|compound|END_ENTITY	BAY_K_8644 , a calcium channel agonist , inhibits renin secretion in vitro .
2438493	0	calcium	64,71	renin	44,49	calcium	renin	MESH:D002118	24715(Tax:10116)	Chemical	Gene	influence|nmod|START_ENTITY END_ENTITY|dep|influence	Cultured glomerular mesangial cells contain renin : influence of calcium and isoproterenol .
2439680	0	calcium	22,29	renin	50,55	calcium	renin	MESH:D002118	24715(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY effects|nmod|channel agonists|nsubj|effects agonists|nmod|release release|compound|END_ENTITY	Inhibitory effects of calcium channel agonists on renin release from rat kidney cortical slices .
2645917	0	calcium	25,32	renin	76,81	calcium	renin	MESH:D002118	5972	Chemical	Gene	responses|compound|START_ENTITY pressure|dobj|responses pressure|nmod|hypertension hypertension|compound|END_ENTITY	Blood pressure and serum calcium responses to altered sodium intake in high renin hypertension .
2664559	0	calcium	15,22	renin	48,53	calcium	renin	MESH:D002118	5972	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	-LSB- Serum ionized calcium , parathormone and plasma renin activity in essential arterial hypertension -RSB- .
2856063	0	calcium	97,104	renin	38,43	calcium	renin	MESH:D002118	24715(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|stimulation stimulation|nmod|END_ENTITY	Calmodulin-independent stimulation of renin release by exposure of rat kidney cortical slices to calcium .
3014894	0	calcium	14,21	renin	31,36	calcium	renin	MESH:D002118	24715(Tax:10116)	Chemical	Gene	Importance|nmod|START_ENTITY Importance|nmod|release release|compound|END_ENTITY	Importance of calcium in renal renin release .
3051994	0	calcium	11,18	renin	22,27	calcium	renin	MESH:D002118	24715(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of calcium on renin and aldosterone .
3142397	0	calcium	19,26	renin	79,84	calcium	renin	MESH:D002118	5972	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|nmod|hypertension hypertension|dep|play play|nsubj|END_ENTITY	-LSB- Acute response to calcium inhibitors in secondary arterial hypertension : does renin play a role ? -RSB- .
3286065	0	calcium	10,17	renin	186,191	calcium	renin	MESH:D002118	24715(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY ventricular|nsubj|Effect ventricular|nmod|activity activity|compound|END_ENTITY	Effect of calcium blocking agent verapamil on blood pressure , ventricular contractility , parathyroid_hormone , calcium and phosphorus in plasma , catecholamines , corticosterone and plasma renin activity in spontaneously hypertensive rats .
3293796	0	calcium	35,42	renin	54,59	calcium	renin	MESH:D002118	5972	Chemical	Gene	paradox|compound|START_ENTITY interpretation|nmod|paradox interpretation|nmod|secretion secretion|compound|END_ENTITY	Hypothetical interpretation of the calcium paradox in renin secretion .
3511220	0	calcium	40,47	renin	60,65	calcium	renin	MESH:D002118	24715(Tax:10116)	Chemical	Gene	substitutes|nmod|START_ENTITY substitutes|nmod|secretion secretion|compound|END_ENTITY	Extracellular strontium substitutes for calcium in in vitro renin secretion .
3542105	0	calcium	103,110	renin	31,36	calcium	renin	MESH:D002118	24715(Tax:10116)	Chemical	Gene	flux|compound|START_ENTITY affecting|dobj|flux factors|acl|affecting release|nmod|factors release|nsubj|Stimulation Stimulation|nmod|END_ENTITY	Stimulation and suppression of renin release from incubations of rat renal cortex by factors affecting calcium flux .
366108	0	calcium	118,125	renin	63,68	calcium	renin	MESH:D002118	403838(Tax:9615)	Chemical	Gene	interactions|nmod|START_ENTITY effect|dep|interactions effect|acl|increasing increasing|nmod|release release|compound|END_ENTITY	The effect of increasing the plasma magnesium concentration on renin release from the dog 's kidney : interactions with calcium and sodium .
3884503	0	calcium	52,59	renin	5,10	calcium	renin	MESH:D002118	24715(Tax:10116)	Chemical	Gene	blockers|compound|START_ENTITY determine|nmod|blockers determine|nsubj|END_ENTITY	Does renin determine the blood pressure response to calcium entry blockers ?
3893987	0	calcium	33,40	renin	59,64	calcium	renin	MESH:D002118	24715(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|release release|compound|END_ENTITY	Role of extra - and intracellular calcium and calmodulin in renin release from rat kidney .
415132	0	calcium	93,100	renin	28,33	calcium	renin	MESH:D002118	24715(Tax:10116)	Chemical	Gene	ionophore|compound|START_ENTITY effects|nmod|ionophore Studies|dep|effects Studies|nmod|mechanism mechanism|nmod|release release|compound|END_ENTITY	Studies on the mechanism of renin release from isolated superfused rat glomeruli : effects of calcium , calcium ionophore and lanthanum .
4365157	0	calcium	23,30	renin	38,43	calcium	renin	MESH:D002118	5972	Chemical	Gene	ion|compound|START_ENTITY ion|nmod|release release|compound|END_ENTITY	Proceedings : Effect of calcium ion on renin release from renal cortex slices and isolated renin granules .
4436432	0	calcium	28,35	renin	61,66	calcium	renin	MESH:D002118	24715(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY Effect|nmod|administration Effect|nmod|END_ENTITY	Effect of acute and chronic calcium administration on plasma renin .
6093795	0	calcium	35,42	renin	3,8	calcium	renin	MESH:D002118	5972	Chemical	Gene	permeability|compound|START_ENTITY governed|nmod|permeability governed|nsubjpass|secretion secretion|compound|END_ENTITY	Is renin secretion governed by the calcium permeability of the juxtaglomerular cell membrane ?
6096938	0	calcium	10,17	renin	47,52	calcium	renin	MESH:D002118	24715(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of calcium , sodium and isoproterenol on renin secretion from disaggregated rat renal cortical cells .
624999	0	calcium	121,128	renin	15,20	calcium	renin	MESH:D002118	5972	Chemical	Gene	deprivation|compound|START_ENTITY efflux|nmod|deprivation efflux|nsubj|Stimulation Stimulation|nmod|secretion secretion|compound|END_ENTITY	Stimulation of renin secretion and calcium efflux from the isolated perfused cat kidney by noradrenaline after prolonged calcium deprivation .
6312014	0	calcium	8,15	renin	75,80	calcium	renin	MESH:D002118	100358545(Tax:9986)	Chemical	Gene	START_ENTITY|nmod|interaction interaction|nmod|release release|amod|END_ENTITY	Role of calcium in the interaction of alpha and beta adrenoceptor-mediated renin release in isolated , constant pressure perfused rabbit kidneys .
6362426	0	calcium	71,78	renin	15,20	calcium	renin	MESH:D002118	24715(Tax:10116)	Chemical	Gene	dependence|nmod|START_ENTITY Suppression|dep|dependence Suppression|nmod|secretion secretion|compound|END_ENTITY	Suppression of renin secretion by insulin : dependence on extracellular calcium .
6369334	0	calcium	40,47	renin	23,28	calcium	renin	MESH:D002118	24715(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|alteration alteration|nmod|END_ENTITY	Biphasic alteration of renin release by calcium .
6418882	0	calcium	60,67	renin	42,47	calcium	renin	MESH:D002118	100358545(Tax:9986)	Chemical	Gene	effects|nmod|START_ENTITY control|dep|effects control|nmod|END_ENTITY	Secretion control for active and inactive renin : effects of calcium and potassium on rabbit kidney cortex slices .
6439011	0	calcium	32,39	renin	67,72	calcium	renin	MESH:D002118	403838(Tax:9615)	Chemical	Gene	changes|nmod|START_ENTITY effects|nmod|changes effects|nmod|activity activity|compound|END_ENTITY	The effects of changes in serum calcium and parathormone on plasma renin activity in intact mongrel dogs .
6750722	0	calcium	84,91	renin	60,65	calcium	renin	MESH:D002118	24715(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY secretion|nmod|concentration secretion|compound|END_ENTITY	Calcium and renin release : inhibition of low sodium-induced renin secretion by high calcium concentration in rat kidney perfusion .
6750722	1	calcium	157,164	renin	168,173	calcium	renin	MESH:D002118	24715(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	The effects of changes in calcium on renin secretion have been studied in the isolated perfused rat kidney .
6756681	0	calcium	67,74	renin	42,47	calcium	renin	MESH:D002118	24715(Tax:10116)	Chemical	Gene	ions|compound|START_ENTITY interactions|nmod|ions control|dep|interactions control|nmod|END_ENTITY	Secretion control for active and inactive renin : interactions with calcium and sodium ions .
7003100	0	calcium	66,73	renin	28,33	calcium	renin	MESH:D002118	24715(Tax:10116)	Chemical	Gene	Studies|dep|START_ENTITY Studies|nmod|mechanism mechanism|nmod|release release|compound|END_ENTITY	Studies on the mechanism of renin release from rat kidney slices : calcium , sodium and metabolic inhibition .
7595137	0	calcium	15,22	renin	75,80	calcium	renin	MESH:D002118	5972	Chemical	Gene	supplementation|compound|START_ENTITY Effect|nmod|supplementation END_ENTITY|nsubj|Effect	Effect of oral calcium supplementation on intracellular calcium and plasma renin in men .
7595137	0	calcium	56,63	renin	75,80	calcium	renin	MESH:D002118	5972	Chemical	Gene	supplementation|nmod|START_ENTITY Effect|nmod|supplementation END_ENTITY|nsubj|Effect	Effect of oral calcium supplementation on intracellular calcium and plasma renin in men .
7971174	0	calcium	8,15	renin	48,53	calcium	renin	MESH:D002118	24715(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY ions|nsubj|Role ions|nmod|control control|nmod|secretion secretion|compound|END_ENTITY	Role of calcium ions in the pressure control of renin secretion from the kidneys .
8331562	0	calcium	70,77	renin	43,48	calcium	renin	MESH:D002118	24715(Tax:10116)	Chemical	Gene	blockers|compound|START_ENTITY effect|nmod|blockers mechanism|dep|effect mechanism|nmod|secretion secretion|compound|END_ENTITY	The baroreceptor mechanism for controlling renin secretion : effect of calcium channel blockers .
851195	0	calcium	55,62	renin	15,20	calcium	renin	MESH:D002118	24715(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|Stimulation Stimulation|nmod|END_ENTITY	Stimulation of renin release in perfused kidney by low calcium and high magnesium .
967887	0	calcium	39,46	renin	22,27	calcium	renin	MESH:D002118	24715(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|stimulation stimulation|nmod|END_ENTITY	Direct stimulation of renin release by calcium .
10026226	0	calcium	55,62	ryanodine_receptor	21,39	calcium	ryanodine receptor	MESH:D002118	6261	Chemical	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	Skeletal muscle type ryanodine_receptor is involved in calcium signaling in human B lymphocytes .
10692315	0	calcium	115,122	ryanodine_receptor	48,66	calcium	ryanodine receptor	MESH:D002118	49090(Tax:7227)	Chemical	Gene	channel|compound|START_ENTITY studies|nmod|channel studies|amod|END_ENTITY	Molecular cloning of cDNA encoding a drosophila ryanodine_receptor and functional studies of the carboxyl-terminal calcium release channel .
11274202	0	calcium	52,59	ryanodine_receptor	77,95	calcium	ryanodine receptor	MESH:D002118	6262	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Calmodulin binding and inhibition of cardiac muscle calcium release channel -LRB- ryanodine_receptor -RRB- .
11733405	0	calcium	50,57	ryanodine_receptor	75,93	calcium	ryanodine receptor	MESH:D002118	6262	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	beta-adrenergic receptor blockers restore cardiac calcium release channel -LRB- ryanodine_receptor -RRB- structure and function in heart_failure .
11861420	0	calcium	75,82	ryanodine_receptor	40,58	calcium	ryanodine receptor	MESH:D002118	20190(Tax:10090)	Chemical	Gene	sparks|compound|START_ENTITY affect|dobj|sparks affect|nsubj|phosphorylation phosphorylation|nmod|END_ENTITY	Protein kinase A phosphorylation of the ryanodine_receptor does not affect calcium sparks in mouse ventricular myocytes .
12629052	0	calcium	34,41	ryanodine_receptor	59,77	calcium	ryanodine receptor	MESH:D002118	6261	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	PKA phosphorylation activates the calcium release channel -LRB- ryanodine_receptor -RRB- in skeletal muscle : defective regulation in heart_failure .
12637263	0	calcium	88,95	ryanodine_receptor	47,65	calcium	ryanodine receptor	MESH:D002118	689560(Tax:10116)	Chemical	Gene	activated|nmod|START_ENTITY channels|acl|activated channels|compound|END_ENTITY	SH oxidation coordinates subunits of rat brain ryanodine_receptor channels activated by calcium and ATP .
12837242	0	calcium	34,41	ryanodine_receptor	59,77	calcium	ryanodine receptor	MESH:D002118	6262	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	FKBP12 .6 deficiency and defective calcium release channel -LRB- ryanodine_receptor -RRB- function linked to exercise-induced sudden_cardiac_death .
15197150	0	calcium	77,84	ryanodine_receptor	102,120	calcium	ryanodine receptor	MESH:D002118	6262	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Sudden_death in familial polymorphic ventricular_tachycardia associated with calcium release channel -LRB- ryanodine_receptor -RRB- leak .
17023043	0	calcium	127,134	ryanodine_receptor	108,126	calcium	ryanodine receptor	MESH:D002118	6261	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	The Mu class glutathione transferase is abundant in striated muscle and is an isoform-specific regulator of ryanodine_receptor calcium channels .
17030344	0	calcium	37,44	ryanodine_receptor	18,36	calcium	ryanodine receptor	MESH:D002118	6261	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Regulation of the ryanodine_receptor calcium release channel : a molecular complex system .
17052227	0	calcium	43,50	ryanodine_receptor	24,42	calcium	ryanodine receptor	MESH:D002118	6261	Chemical	Gene	release|nsubj|START_ENTITY regulation|parataxis|release regulation|nmod|END_ENTITY	Redox regulation of the ryanodine_receptor / calcium release channel .
17713923	0	calcium	101,108	ryanodine_receptor	82,100	calcium	ryanodine receptor	MESH:D002118	6261	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Calcium occupancy of N-terminal sites within calmodulin induces inhibition of the ryanodine_receptor calcium release channel .
17951303	0	calcium	40,47	ryanodine_receptor	61,79	calcium	ryanodine receptor	MESH:D002118	6261	Chemical	Gene	channel|compound|START_ENTITY selectivity|nmod|channel Energetics|nmod|selectivity Energetics|dep|END_ENTITY	Energetics of divalent selectivity in a calcium channel : the ryanodine_receptor case study .
18006456	0	calcium	44,51	ryanodine_receptor	14,32	calcium	ryanodine receptor	MESH:D002118	6262	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|END_ENTITY	Modulation of ryanodine_receptor by luminal calcium and accessory proteins in health and cardiac_disease .
18077344	0	calcium	78,85	ryanodine_receptor	10,28	calcium	ryanodine receptor	MESH:D002118	6262	Chemical	Gene	leak|compound|START_ENTITY increases|dobj|leak increases|nsubj|S-nitrosylation S-nitrosylation|compound|END_ENTITY	Deficient ryanodine_receptor S-nitrosylation increases sarcoplasmic reticulum calcium leak and arrhythmogenesis in cardiomyocytes .
18313359	0	calcium	63,70	ryanodine_receptor	44,62	calcium	ryanodine receptor	MESH:D002118	6261	Chemical	Gene	paradigm|compound|START_ENTITY END_ENTITY|dep|paradigm	Congenital_muscle_disorders with cores : the ryanodine_receptor calcium channel paradigm .
19126405	0	calcium	133,140	ryanodine_receptor	64,82	calcium	ryanodine receptor	MESH:D002118	20190(Tax:10090)	Chemical	Gene	induced|dobj|START_ENTITY receptor|acl|induced END_ENTITY|dep|receptor	The actin cytoskeleton differentially regulates NG115-401L cell ryanodine_receptor and inositol_1 ,4,5 - trisphosphate receptor induced calcium signaling pathways .
19198614	0	calcium	37,44	ryanodine_receptor	18,36	calcium	ryanodine receptor	MESH:D002118	20190(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Hypernitrosylated ryanodine_receptor calcium release channels are leaky in dystrophic_muscle .
19278523	0	calcium	37,44	ryanodine_receptor	18,36	calcium	ryanodine receptor	MESH:D002118	6261	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dobj|channels	Control of muscle ryanodine_receptor calcium release channels by proteins in the sarcoplasmic reticulum lumen .
20139707	0	calcium	25,32	ryanodine_receptor	93,111	calcium	ryanodine receptor	MESH:D002118	100009439(Tax:9986)	Chemical	Gene	Changes|nmod|START_ENTITY Changes|nmod|sensitization sensitization|nmod|channels channels|compound|END_ENTITY	Changes in intra-luminal calcium during spontaneous calcium waves following sensitization of ryanodine_receptor channels .
20139707	0	calcium	52,59	ryanodine_receptor	93,111	calcium	ryanodine receptor	MESH:D002118	100009439(Tax:9986)	Chemical	Gene	waves|compound|START_ENTITY Changes|nmod|waves Changes|nmod|sensitization sensitization|nmod|channels channels|compound|END_ENTITY	Changes in intra-luminal calcium during spontaneous calcium waves following sensitization of ryanodine_receptor channels .
20643651	0	calcium	102,109	ryanodine_receptor	32,50	calcium	ryanodine receptor	MESH:D002118	689560(Tax:10116)	Chemical	Gene	leak|compound|START_ENTITY contributes|nmod|leak contributes|nsubj|S-nitrosylation S-nitrosylation|nmod|END_ENTITY	Impaired S-nitrosylation of the ryanodine_receptor caused by xanthine oxidase activity contributes to calcium leak in heart_failure .
25418295	0	calcium	28,35	ryanodine_receptor	49,67	calcium	ryanodine receptor	MESH:D002118	6261	Chemical	Gene	channel|compound|START_ENTITY ions|nmod|channel ions|dep|END_ENTITY	Selecting ions by size in a calcium channel : the ryanodine_receptor case study .
7514503	0	calcium	17,24	ryanodine_receptor	42,60	calcium	ryanodine receptor	MESH:D002118	6261	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Stabilization of calcium release channel -LRB- ryanodine_receptor -RRB- function by FK506-binding_protein .
7669046	0	calcium	48,55	ryanodine_receptor	29,47	calcium	ryanodine receptor	MESH:D002118	6261	Chemical	Gene	channel|compound|START_ENTITY skeletal|nsubj|channel purification|parataxis|skeletal purification|nmod|END_ENTITY	Affinity purification of the ryanodine_receptor / calcium release channel from fast twitch skeletal muscle based on its tight association with FKBP12 .
7744771	0	calcium	66,73	ryanodine_receptor	91,109	calcium	ryanodine receptor	MESH:D002118	6261	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Lumenal sites and C terminus accessibility of the skeletal muscle calcium release channel -LRB- ryanodine_receptor -RRB- .
7209397	0	calcium	79,86	secretin	24,32	calcium	secretin	MESH:D002118	6343	Chemical	Gene	infusion|compound|START_ENTITY secretion|nmod|infusion secretion|compound|END_ENTITY	Plasma concentration of secretin and gastric secretion following intraduodenal calcium infusion in man .
21646743	0	calcium	72,79	serum_amyloid_a	11,26	calcium	serum amyloid a	MESH:D002118	6287	Chemical	Gene	concentration|compound|START_ENTITY Effects|nmod|concentration Effects|nmod|END_ENTITY	Effects of serum_amyloid_a and lysophosphatidylcholine on intracellular calcium concentration in human coronary artery smooth muscle cells .
12628440	0	calcium	24,31	serum_and_glucocorticoid-inducible_kinase_1	42,85	calcium	serum and glucocorticoid-inducible kinase 1	MESH:D002118	100771433	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Increased intracellular calcium activates serum_and_glucocorticoid-inducible_kinase_1 -LRB- SGK1 -RRB- through a calmodulin-calcium calmodulin dependent kinase kinase pathway in Chinese_hamster ovary cells .
1676943	0	calcium	46,53	snail	65,70	calcium	snail	MESH:D002118	6615	Chemical	Gene	current|compound|START_ENTITY current|nmod|neurons neurons|compound|END_ENTITY	The effect of oxytocin on potential-dependent calcium current in snail neurons , Helix pomatia .
11031255	0	calcium	51,58	soluble_guanylyl_cyclase	14,38	calcium	soluble guanylyl cyclase	MESH:D002118	25206(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Dependence of soluble_guanylyl_cyclase activity on calcium signaling in pituitary cells .
20504713	0	calcium	40,47	somatostatin	65,77	calcium	somatostatin	MESH:D002118	6750	Chemical	Gene	channels|compound|START_ENTITY Activation|nmod|channels induces|nsubj|Activation induces|dobj|release release|compound|END_ENTITY	Activation of dihydropyridine-sensitive calcium channels induces somatostatin release from hypothalamic neurons .
222349	0	calcium	14,21	somatostatin	25,37	calcium	somatostatin	MESH:D002118	20604(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|compound|END_ENTITY	The effect of calcium on somatostatin inhibition of insulin release and cyclic_AMP production in mouse pancreatic islets .
2877894	0	calcium	68,75	somatostatin	21,33	calcium	somatostatin	MESH:D002118	6750	Chemical	Gene	absorption|compound|START_ENTITY effect|nmod|absorption infusion|dep|effect infusion|nmod|END_ENTITY	Low-dose infusion of somatostatin in man -- no effect upon intestinal calcium absorption but a fall in blood insulin .
2891695	2	calcium	209,216	somatostatin	229,241	calcium	somatostatin	MESH:D002118	24797(Tax:10116)	Chemical	Gene	START_ENTITY|acl|produced produced|nmod|END_ENTITY	An increase in potassium conductance is responsible for both the hyperpolarization and the decrease in intracellular free calcium produced by somatostatin .
478196	0	calcium	44,51	somatostatin	71,83	calcium	somatostatin	MESH:D002118	24797(Tax:10116)	Chemical	Gene	Gastrointestinal_motility|nmod|START_ENTITY Gastrointestinal_motility|nmod|END_ENTITY	Gastrointestinal_motility and absorption of calcium during infusion of somatostatin in the rat .
6136008	0	calcium	120,127	somatostatin	53,65	calcium	somatostatin	MESH:D002118	20604(Tax:10090)	Chemical	Gene	dependence|nmod|START_ENTITY Inhibition|dep|dependence Inhibition|nmod|kinase kinase|nmod|END_ENTITY	Inhibition of cyclic_AMP-dependent protein kinase by somatostatin in slices of mouse brain : dependence on extracellular calcium .
6144272	0	calcium	15,22	somatostatin	37,49	calcium	somatostatin	MESH:D002118	6750	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A dual role of calcium in release of somatostatin from canine gastric antral mucosa .
675155	0	calcium	25,32	somatostatin	47,59	calcium	somatostatin	MESH:D002118	6750	Chemical	Gene	absorption|compound|START_ENTITY absorption|nmod|END_ENTITY	The effect on intestinal calcium absorption of somatostatin in man .
8103554	0	calcium	61,68	somatostatin	80,92	calcium	somatostatin	MESH:D002118	396279(Tax:9031)	Chemical	Gene	current|compound|START_ENTITY current|nmod|END_ENTITY	Kinetic basis for the voltage-dependent inhibition of N-type calcium current by somatostatin and norepinephrine in chick sympathetic neurons .
8815883	0	calcium	37,44	somatostatin	57,69	calcium	somatostatin	MESH:D002118	24797(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|nmod|END_ENTITY	Modulation of high voltage-activated calcium channels by somatostatin in acutely isolated rat amygdaloid neurons .
19605612	0	calcium	61,68	somatostatin-14	21,36	calcium	somatostatin-14	MESH:D002118	396279(Tax:9031)	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|nmod|channels	Inhibitory effect of somatostatin-14 on L-type voltage-gated calcium channels in cultured cone photoreceptors requires intracellular calcium .
11922676	0	calcium	36,43	sorcin	29,35	calcium	sorcin	MESH:D002118	6717	Chemical	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	The crystal structure of the sorcin calcium binding domain provides a model of Ca2 + - dependent processes in the full-length protein .
9378856	0	calcium	49,56	sorcin	32,38	calcium	sorcin	MESH:D002118	683667(Tax:10116)	Chemical	Gene	binding|nmod:npmod|START_ENTITY protein|amod|binding localization|appos|protein localization|nmod|END_ENTITY	Ultrastructural localization of sorcin , a 22 kDa calcium binding protein , in the rat caudate-putamen nucleus : association with ryanodine_receptors and intracellular calcium release .
20480274	0	calcium	9,16	spinocerebellar_ataxia_2	65,89	calcium	spinocerebellar ataxia 2	MESH:D002118	6311	Chemical	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Deranged calcium signaling in Purkinje cells and pathogenesis in spinocerebellar_ataxia_2 -LRB- SCA2 -RRB- and other ataxias .
7829534	0	calcium	61,68	stanniocalcin	39,52	calcium	stanniocalcin	MESH:D002118	6781	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|gene gene|compound|END_ENTITY	Post-transcriptional regulation of the stanniocalcin gene by calcium .
2453427	0	calcium	22,29	substance_P	48,59	calcium	substance P	MESH:D002118	6863	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of extracellular calcium in the effects of substance_P and neurokinin_A on guinea_pig trachea and human bronchus .
2433392	0	calcium	12,19	thioredoxin_reductase	67,88	calcium	thioredoxin reductase	MESH:D002118	25824	Chemical	Gene	role|nmod|START_ENTITY role|nmod|regulation regulation|nmod|reduction reduction|nmod|END_ENTITY	The role of calcium in the regulation of free radical reduction by thioredoxin_reductase at the surface of the skin .
2475107	0	calcium	9,16	thioredoxin_reductase	39,60	calcium	thioredoxin reductase	MESH:D002118	25824	Chemical	Gene	binding|compound|START_ENTITY regulates|nsubj|binding regulates|dobj|transfer transfer|amod|END_ENTITY	EF-hands calcium binding regulates the thioredoxin_reductase / thioredoxin electron transfer in human keratinocytes .
8224207	0	calcium	28,35	thioredoxin_reductase	56,77	calcium	thioredoxin reductase	MESH:D002118	25824	Chemical	Gene	regulation|compound|START_ENTITY absence|nmod|regulation comment|nmod|absence comment|nmod|END_ENTITY	A comment on the absence of calcium regulation of human thioredoxin_reductase .
10938903	0	calcium	37,44	thrombin	11,19	calcium	thrombin	MESH:D002118	2147	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of thrombin on intracellular calcium and pH in human and murine platelets .
10957669	0	calcium	14,21	thrombin	87,95	calcium	thrombin	MESH:D002118	2147	Chemical	Gene	response|compound|START_ENTITY exposed|nsubj|response exposed|xcomp|flow flow|nmod|presence presence|nmod|END_ENTITY	Intracellular calcium response of endothelial cells exposed to flow in the presence of thrombin or histamine .
12435596	0	calcium	53,60	thrombin	28,36	calcium	thrombin	MESH:D002118	2147	Chemical	Gene	C|compound|START_ENTITY dependent|nmod|C dependent|nsubj|ERK2 ERK2|acl|activation activation|nmod|END_ENTITY	Platelet ERK2 activation by thrombin is dependent on calcium and conventional protein kinases C but not Raf-1 or B-Raf .
1334492	0	calcium	16,23	thrombin	51,59	calcium	thrombin	MESH:D002118	2147	Chemical	Gene	START_ENTITY|nmod|C C|acl|activation activation|nmod|END_ENTITY	The function of calcium in protein C activation by thrombin and the thrombin-thrombomodulin complex can be distinguished by mutational analysis of protein C derivatives .
1387801	0	calcium	89,96	thrombin	48,56	calcium	thrombin	MESH:D002118	2147	Chemical	Gene	increase|nmod|START_ENTITY Response|dep|increase Response|nmod|line line|nmod|END_ENTITY	Response of a human megakaryocytic cell line to thrombin : increase in intracellular free calcium and mitogen release .
15313016	0	calcium	160,167	thrombin	34,42	calcium	thrombin	MESH:D002118	2147	Chemical	Gene	regulated|nmod|START_ENTITY manner|acl|regulated associated|nmod|manner associated|nsubjpass|stimulation stimulation|nmod|receptor receptor|compound|END_ENTITY	Sustained stimulation of platelet thrombin receptor is associated with tyrosine dephosphorylation of a novel p67 peptide in a manner regulated by extracellular calcium .
1560043	0	calcium	102,109	thrombin	40,48	calcium	thrombin	MESH:D002118	2147	Chemical	Gene	rises|nmod|START_ENTITY induction|nmod|rises necessary|nmod|induction necessary|nsubj|exosite exosite|nmod|END_ENTITY	The fibrinogen anion-binding exosite of thrombin is necessary for induction of rises in intracellular calcium and prostacyclin production in endothelial cells .
1771408	3	calcium	538,545	thrombin	465,473	calcium	thrombin	MESH:D002118	2147	Chemical	Gene	thrombin|compound|START_ENTITY gave|nsubj|thrombin sensitive|advcl|gave sensitive|nsubj|time time|compound|END_ENTITY	The 10 U/ml thrombin time assay was very sensitive to r-hirudin , whereas the 10 U/ml calcium thrombin time gave a dose-dependent response from 0.15 to 10.0 micrograms/ml .
1999477	0	calcium	40,47	thrombin	145,153	calcium	thrombin	MESH:D002118	2147	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|parataxis|contrasting contrasting|dobj|effects effects|nmod|END_ENTITY	WS-1 human fibroblasts contain distinct calcium and protein kinase C-mediated pathways for activation of Na + / H + exchange : contrasting effects of thrombin and PMA .
20230276	0	calcium	83,90	thrombin	114,122	calcium	thrombin	MESH:D002118	2147	Chemical	Gene	transients|compound|START_ENTITY transients|acl|elicited elicited|nmod|END_ENTITY	Functional identification of neural stem cell-derived oligodendrocytes by means of calcium transients elicited by thrombin .
2158066	0	calcium	30,37	thrombin	11,19	calcium	thrombin	MESH:D002118	2147	Chemical	Gene	channels|compound|START_ENTITY Effects|nmod|channels Effects|nmod|END_ENTITY	Effects of thrombin on single calcium channels in frog ventricular cells .
2353343	0	calcium	14,21	thrombin	30,38	calcium	thrombin	MESH:D002118	2147	Chemical	Gene	ions|compound|START_ENTITY ions|nmod|END_ENTITY	Inhibition by calcium ions of thrombin .
2359405	0	calcium	45,52	thrombin	90,98	calcium	thrombin	MESH:D002118	2147	Chemical	Gene	rise|nmod|START_ENTITY rise|acl|produced produced|nmod|END_ENTITY	Adenosine inhibits the rise in intracellular calcium and platelet_aggregation produced by thrombin : evidence that both effects are coupled to adenylate cyclase .
2369894	0	calcium	61,68	thrombin	105,113	calcium	thrombin	MESH:D002118	2147	Chemical	Gene	START_ENTITY|acl|resulting resulting|nmod|END_ENTITY	Recombinant human protein C derivatives : altered response to calcium resulting in enhanced activation by thrombin .
2730914	0	calcium	29,36	thrombin	89,97	calcium	thrombin	MESH:D002118	2147	Chemical	Gene	mobilization|compound|START_ENTITY removal|nmod|mobilization Effects|nmod|removal induced|nsubj|Effects induced|nmod|END_ENTITY	Effects of sodium removal on calcium mobilization and dense granule secretion induced by thrombin in human platelets .
3550638	0	calcium	59,66	thrombin	91,99	calcium	thrombin	MESH:D002118	2147	Chemical	Gene	mobilization|compound|START_ENTITY mobilization|acl|induced induced|nmod|END_ENTITY	-LSB- Effects of SIN-1 on the activation of phospholipase C and calcium mobilization induced by thrombin in blood platelets -RSB- .
3929831	2	calcium	72,79	thrombin	97,105	calcium	thrombin	MESH:D002118	2147	Chemical	Gene	Calorimetry|nmod|START_ENTITY Calorimetry|acl|clotting clotting|nmod|END_ENTITY	Calorimetry of the reversal of the effect of calcium on clotting with thrombin and with ancrod .
408379	0	calcium	16,23	thrombin	96,104	calcium	thrombin	MESH:D002118	2147	Chemical	Gene	effects|nmod|START_ENTITY protein|nsubj|effects protein|nmod|END_ENTITY	Some effects of calcium on the activation of human factor VIII/Von _ Willebrand_factor protein by thrombin .
579513	0	calcium	10,17	thrombin	49,57	calcium	thrombin	MESH:D002118	2147	Chemical	Gene	ion|compound|START_ENTITY Effect|nmod|ion Effect|nmod|interaction interaction|nmod|END_ENTITY	Effect of calcium ion on the interaction between thrombin and heparin .
6091624	0	calcium	125,132	thrombin	136,144	calcium	thrombin	MESH:D002118	2147	Chemical	Gene	concentrations|nmod|START_ENTITY evoked|nmod|concentrations evoked|nmod|END_ENTITY	Effects of prostaglandin_I2 and forskolin on the secretion from platelets evoked at basal concentrations of cytoplasmic free calcium by thrombin , collagen , phorbol_ester and exogenous diacylglycerol .
6204690	1	calcium	109,116	thrombin	141,149	calcium	thrombin	MESH:D002118	2147	Chemical	Gene	Regulation|nmod|START_ENTITY pump|nsubj|Regulation pump|nmod|stimulation stimulation|compound|END_ENTITY	Regulation by an intracellular nonmitochondrial calcium pump and increase after thrombin stimulation .
6318378	0	calcium	41,48	thrombin	82,90	calcium	thrombin	MESH:D002118	2147	Chemical	Gene	START_ENTITY|nmod|platelets platelets|acl|stimulated stimulated|nmod|END_ENTITY	Effect of cyclic_AMP on cytoplasmic free calcium in human platelets stimulated by thrombin : direct measurement with quin2 .
7516333	0	calcium	29,36	thrombin	71,79	calcium	thrombin	MESH:D002118	2147	Chemical	Gene	START_ENTITY|acl|signaling signaling|nmod|activation activation|nmod|receptor receptor|compound|END_ENTITY	Differences in intracellular calcium signaling after activation of the thrombin receptor by thrombin and agonist peptide in osteoblast-like cells .
7516333	0	calcium	29,36	thrombin	92,100	calcium	thrombin	MESH:D002118	2147	Chemical	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Differences in intracellular calcium signaling after activation of the thrombin receptor by thrombin and agonist peptide in osteoblast-like cells .
7540318	0	calcium	24,31	thrombin	114,122	calcium	thrombin	MESH:D002118	2147	Chemical	Gene	Changes|nmod|START_ENTITY caused|nsubj|Changes caused|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Changes of cytoplasmic calcium and magnesium concentration and calcium distribution in human platelets caused by thrombin -RSB- .
7660815	5	calcium	610,617	thrombin	578,586	calcium	thrombin	MESH:D002118	2147	Chemical	Gene	adding|dobj|START_ENTITY reduced|advcl|adding reduced|nsubjpass|effects effects|nmod|Que Que|nmod|platelet_aggregation platelet_aggregation|acl|induced induced|nmod|END_ENTITY	The inhibitory effects of Que on platelet_aggregation induced by thrombin were reduced by adding calcium to the medium , and Que had no effect on thrombin-induced internal Ca2 + release from dense tubular system .
7752628	0	calcium	33,40	thrombin	53,61	calcium	thrombin	MESH:D002118	2147	Chemical	Gene	response|compound|START_ENTITY Difference|nmod|response Difference|xcomp|END_ENTITY	Difference in platelet cytosolic calcium response to thrombin in alcoholic withdrawal and sober patients .
7964131	0	calcium	21,28	thrombin	90,98	calcium	thrombin	MESH:D002118	2147	Chemical	Gene	Changes|nmod|START_ENTITY ion|nsubj|Changes ion|nmod|END_ENTITY	Changes of cytosolic calcium ion concentrations in human endothelial cells in response to thrombin , platelet-activating factor , and leukotriene B4 .
8228559	0	calcium	34,41	thrombin	57,65	calcium	thrombin	MESH:D002118	2147	Chemical	Gene	mobilize|dobj|START_ENTITY mobilize|advcl|END_ENTITY	Failure to mobilize intracellular calcium in response to thrombin in a patient with familial_thrombocytopathy characterized by macrothrombocytopenia and abnormal platelet membrane complexes .
8607117	0	calcium	92,99	thrombin	23,31	calcium	thrombin	MESH:D002118	2147	Chemical	Gene	rise|compound|START_ENTITY induce|dobj|rise activating|advcl|induce abilities|acl|activating abilities|nmod|receptor receptor|compound|END_ENTITY	Different abilities of thrombin receptor activating peptide and thrombin to induce platelet calcium rise and full release reaction .
8761314	0	calcium	5,12	thrombin	124,132	calcium	thrombin	MESH:D002118	29251(Tax:10116)	Chemical	Gene	handling|compound|START_ENTITY handling|dep|response response|nmod|stimulation stimulation|compound|END_ENTITY	Cell calcium handling and intracellular pH regulation in hereditary hypertriglyceridemic rats : reduced platelet response to thrombin stimulation .
9925357	0	calcium	45,52	thrombin_receptor	4,21	calcium	thrombin receptor	MESH:D002118	25439(Tax:10116)	Chemical	Gene	elevates|dobj|START_ENTITY elevates|nsubj|END_ENTITY	The thrombin_receptor elevates intracellular calcium in adult rat ventricular myocytes .
1279382	0	calcium	170,177	thyrotropin-releasing_hormone	44,73	calcium	thyrotropin-releasing hormone	MESH:D002118	7200	Chemical	Gene	channels|compound|START_ENTITY importance|nmod|channels Characterization|dep|importance Characterization|nmod|response response|nmod|END_ENTITY	Characterization of the calcium response to thyrotropin-releasing_hormone -LRB- TRH -RRB- in cells transfected with TRH receptor complementary DNA : importance of voltage-sensitive calcium channels .
1279382	0	calcium	24,31	thyrotropin-releasing_hormone	44,73	calcium	thyrotropin-releasing hormone	MESH:D002118	7200	Chemical	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	Characterization of the calcium response to thyrotropin-releasing_hormone -LRB- TRH -RRB- in cells transfected with TRH receptor complementary DNA : importance of voltage-sensitive calcium channels .
1595326	0	calcium	102,109	thyrotropin-releasing_hormone	55,84	calcium	thyrotropin-releasing hormone	MESH:D002118	7200	Chemical	Gene	injection|compound|START_ENTITY comparison|nmod|injection release|dep|comparison release|nmod|medullary_thyroid_carcinoma medullary_thyroid_carcinoma|nmod|END_ENTITY	Calcitonin release from medullary_thyroid_carcinoma by thyrotropin-releasing_hormone : comparison with calcium injection .
18406774	0	calcium	24,31	thyrotropin-releasing_hormone	44,73	calcium	thyrotropin-releasing hormone	MESH:D002118	7200	Chemical	Gene	response|compound|START_ENTITY Characterization|nmod|response Characterization|acl|END_ENTITY	Characterization of the calcium response to thyrotropin-releasing_hormone in lactotrophs and GH cells .
2119294	0	calcium	151,158	thyrotropin-releasing_hormone	55,84	calcium	thyrotropin-releasing hormone	MESH:D002118	25569(Tax:10116)	Chemical	Gene	dynamics|compound|START_ENTITY END_ENTITY|nmod|dynamics	A comparison of the concentration-dependent actions of thyrotropin-releasing_hormone , angiotensin_II , bradykinin , and Lys-bradykinin on cytosolic free calcium dynamics in rat anterior pituitary cells : selective effects of dopamine .
21334313	0	calcium	98,105	thyrotropin-releasing_hormone	31,60	calcium	thyrotropin-releasing hormone	MESH:D002118	7200	Chemical	Gene	study|compound|START_ENTITY nucleus|dep|study amplifies|nmod|nucleus amplifies|dobj|action action|nmod|END_ENTITY	Leptin amplifies the action of thyrotropin-releasing_hormone in the solitary nucleus : an in vitro calcium imaging study .
2446857	0	calcium	21,28	thyrotropin-releasing_hormone	82,111	calcium	thyrotropin-releasing hormone	MESH:D002118	25569(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY transcription|nsubj|role transcription|nmod|END_ENTITY	Preferential role of calcium in the regulation of prolactin gene transcription by thyrotropin-releasing_hormone in GH3 pituitary cells .
2497988	0	calcium	46,53	thyrotropin-releasing_hormone	65,94	calcium	thyrotropin-releasing hormone	MESH:D002118	25569(Tax:10116)	Chemical	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Calcitonin inhibits the rise of intracellular calcium induced by thyrotropin-releasing_hormone in GH3 cells .
2830313	0	calcium	82,89	thyrotropin-releasing_hormone	101,130	calcium	thyrotropin-releasing hormone	MESH:D002118	25569(Tax:10116)	Chemical	Gene	change|nmod|START_ENTITY 1,25-dihydroxycholecalciferol|nmod|change Modulation|nmod|1,25-dihydroxycholecalciferol induced|nsubj|Modulation induced|nmod|END_ENTITY	Modulation by 1,25-dihydroxycholecalciferol of the acute change in cytosolic free calcium induced by thyrotropin-releasing_hormone in GH4C1 pituitary cells .
3141796	0	calcium	72,79	thyrotropin-releasing_hormone	26,55	calcium	thyrotropin-releasing hormone	MESH:D002118	25569(Tax:10116)	Chemical	Gene	mobilization|nmod|START_ENTITY mobilization|amod|END_ENTITY	Dopamine has no effect on thyrotropin-releasing_hormone mobilization of calcium from intracellular stores in rat anterior pituitary cells .
3921543	0	calcium	153,160	thyrotropin-releasing_hormone	82,111	calcium	thyrotropin-releasing hormone	MESH:D002118	25569(Tax:10116)	Chemical	Gene	elevation|nmod|START_ENTITY dependent|nmod|elevation dependent|nsubj|evidence evidence|dep|stimulated stimulated|nmod|END_ENTITY	Direct evidence that burst but not sustained secretion of prolactin stimulated by thyrotropin-releasing_hormone is dependent on elevation of cytoplasmic calcium .
3925349	0	calcium	40,47	thyrotropin-releasing_hormone	51,80	calcium	thyrotropin-releasing hormone	MESH:D002118	25569(Tax:10116)	Chemical	Gene	control|nmod|START_ENTITY control|nmod|END_ENTITY	Bidirectional control of cytosolic free calcium by thyrotropin-releasing_hormone in pituitary cells .
6090104	0	calcium	25,32	thyrotropin-releasing_hormone	81,110	calcium	thyrotropin-releasing hormone	MESH:D002118	25569(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY Evidence|nmod|role Evidence|nmod|messengers messengers|nmod|action action|amod|END_ENTITY	Evidence for the role of calcium and diacylglycerol as dual second messengers in thyrotropin-releasing_hormone action : involvement of diacylglycerol .
6090105	0	calcium	25,32	thyrotropin-releasing_hormone	81,110	calcium	thyrotropin-releasing hormone	MESH:D002118	25569(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY Evidence|nmod|role Evidence|nmod|messengers messengers|nmod|action action|amod|END_ENTITY	Evidence for the role of calcium and diacylglycerol as dual second messengers in thyrotropin-releasing_hormone action : involvement of Ca +2 .
6236219	0	calcium	95,102	thyrotropin-releasing_hormone	32,61	calcium	thyrotropin-releasing hormone	MESH:D002118	25569(Tax:10116)	Chemical	Gene	mobilization|nmod|START_ENTITY mobilization|amod|END_ENTITY	Inositol_trisphosphate mediates thyrotropin-releasing_hormone mobilization of nonmitochondrial calcium in rat mammotropic pituitary cells .
6409774	0	calcium	6,13	thyrotropin-releasing_hormone	58,87	calcium	thyrotropin-releasing hormone	MESH:D002118	7200	Chemical	Gene	decline|nsubj|START_ENTITY decline|nmod|administration administration|nmod|END_ENTITY	Serum calcium decline after intravenous administration of thyrotropin-releasing_hormone in man .
6801079	0	calcium	31,38	thyrotropin-releasing_hormone	77,106	calcium	thyrotropin-releasing hormone	MESH:D002118	7200	Chemical	Gene	inhibition|compound|START_ENTITY Influence|nmod|inhibition Influence|nmod|response response|nmod|END_ENTITY	Influence of metoclopramide on calcium inhibition of thyrotropin response to thyrotropin-releasing_hormone .
7539127	0	calcium	122,129	thyrotropin-releasing_hormone	35,64	calcium	thyrotropin-releasing hormone	MESH:D002118	397780(Tax:8355)	Chemical	Gene	mobilization|compound|START_ENTITY precedes|dobj|mobilization process|acl:relcl|precedes process|nsubj|Desensitization Desensitization|nmod|response response|acl|END_ENTITY	Desensitization of the response to thyrotropin-releasing_hormone in Xenopus oocytes is an amplified process that precedes calcium mobilization .
7720698	0	calcium	29,36	thyrotropin-releasing_hormone	76,105	calcium	thyrotropin-releasing hormone	MESH:D002118	25569(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY Stimulation|nmod|channels pituitary|nsubj|Stimulation pituitary|nmod|END_ENTITY	Stimulation of single L-type calcium channels in rat pituitary GH3 cells by thyrotropin-releasing_hormone .
1724576	0	calcium	15,22	tissue-type_plasminogen_activator	47,80	calcium	tissue-type plasminogen activator	MESH:D002118	25692(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	On the role of calcium in the acute release of tissue-type_plasminogen_activator and von_Willebrand factor from the rat perfused hindleg region .
9351387	0	calcium	15,22	tissue-type_plasminogen_activator	62,95	calcium	tissue-type plasminogen activator	MESH:D002118	5327	Chemical	Gene	proteins|compound|START_ENTITY Involvement|nmod|proteins Involvement|nmod|release release|nmod|END_ENTITY	Involvement of calcium and G proteins in the acute release of tissue-type_plasminogen_activator and von_Willebrand_factor from cultured human endothelial cells .
14706862	0	calcium	27,34	titin	96,101	calcium	titin	MESH:D002118	7273	Chemical	Gene	Myofibrillar|dep|START_ENTITY Myofibrillar|dep|role role|nmod|cation cation|nmod|aggregation aggregation|amod|END_ENTITY	Myofibrillar tightly bound calcium in skeletal muscle fibers : a possible role of this cation in titin strands aggregation .
18690715	0	calcium	122,129	titin	54,59	calcium	titin	MESH:D002118	7273	Chemical	Gene	concentrations|nmod|START_ENTITY enhanced|nmod|concentrations enhanced|nsubjpass|capacities capacities|nmod|region region|nmod|END_ENTITY	Calpain_1 binding capacities of the N1-line region of titin are significantly enhanced by physiological concentrations of calcium .
21555460	8	calcium	1130,1137	titin	1073,1078	calcium	titin	MESH:D002118	22138(Tax:10090)	Chemical	Gene	depends|nmod|START_ENTITY depends|nsubj|movement movement|nmod|END_ENTITY	Our results suggest a model in which the largely unrestricted movement of titin within and between sarcomeres primarily depends on calcium , suggesting that fortification of the titin filament system is activity dependent .
23224300	0	calcium	83,90	titin	33,38	calcium	titin	MESH:D002118	7273	Chemical	Gene	presence|nmod|START_ENTITY domain|nmod|presence immunoglobulin|dobj|domain immunoglobulin|nsubj|properties properties|nmod|END_ENTITY	Altered mechanical properties of titin immunoglobulin domain 27 in the presence of calcium .
1974468	0	calcium	11,18	transglutaminase	69,85	calcium	transglutaminase	MESH:D002118	100379228(Tax:10141)	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of calcium on the stability and activity of guinea_pig liver transglutaminase .
25130439	0	calcium	164,171	transient_receptor_potential_melastatin_7	122,163	calcium	transient receptor potential melastatin 7	MESH:D002118	54822	Chemical	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Endotoxin-induced vascular endothelial cell migration is dependent on TLR4/NF-kB pathway , NAD -LRB- P -RRB- H oxidase activation , and transient_receptor_potential_melastatin_7 calcium channel activity .
21562271	0	calcium	77,84	transient_receptor_potential_vanilloid_4	26,66	calcium	transient receptor potential vanilloid 4	MESH:D002118	63873(Tax:10090)	Chemical	Gene	flux|compound|START_ENTITY modulates|dobj|flux modulates|nsubj|END_ENTITY	The polymodal ion channel transient_receptor_potential_vanilloid_4 modulates calcium flux , spiking rate , and apoptosis of mouse retinal_ganglion cells .
19801845	0	calcium	75,82	transient_receptor_potential_vanilloid_6	34,74	calcium	transient receptor potential vanilloid 6	MESH:D002118	55503	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Altered biochemical properties of transient_receptor_potential_vanilloid_6 calcium channel by peptide tags .
24828496	0	calcium	58,65	transient_receptor_potential_vanilloid_type_5	75,120	calcium	transient receptor potential vanilloid type 5	MESH:D002118	56302	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	b1-Adrenergic receptor signaling activates the epithelial calcium channel , transient_receptor_potential_vanilloid_type_5 -LRB- TRPV5 -RRB- , via the protein kinase A pathway .
4074834	0	calcium	29,36	troponin_C	55,65	calcium	troponin C	MESH:D002118	100301551(Tax:9986)	Chemical	Gene	binding|nmod|START_ENTITY binding|nmod|END_ENTITY	Energetics of the binding of calcium and troponin_I to troponin_C from rabbit skeletal muscle .
14621831	0	calcium	4,11	tumor_necrosis_factor	65,86	calcium	tumor necrosis factor	MESH:D002118	103694380	Chemical	Gene	nisoldipine|compound|START_ENTITY minimizes|nsubj|nisoldipine minimizes|dobj|release release|nmod|transplantation transplantation|amod|END_ENTITY	The calcium channel blocker nisoldipine minimizes the release of tumor_necrosis_factor and interleukin-6 following rat liver transplantation .
1666506	0	calcium	51,58	tumor_necrosis_factor	14,35	calcium	tumor necrosis factor	MESH:D002118	7124	Chemical	Gene	level|compound|START_ENTITY effect|nmod|level effect|nmod|END_ENTITY	The effect of tumor_necrosis_factor -LRB- TNF-alpha -RRB- on calcium -LRB- Ca2 + -RRB- level .
8858023	0	calcium	8,15	tumor_necrosis_factor	49,70	calcium	tumor necrosis factor	MESH:D002118	21926(Tax:10090)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of calcium in lipopolysaccharide-stimulated tumor_necrosis_factor and interleukin-1 signal transduction in naive and endotoxin-tolerant murine macrophages .
11218892	0	calcium	80,87	tumor_necrosis_factor-alpha	12,39	calcium	tumor necrosis factor-alpha	MESH:D002118	7124	Chemical	Gene	concentration|compound|START_ENTITY END_ENTITY|nmod|concentration	-LSB- Effects of tumor_necrosis_factor-alpha on proliferation and intracellular free calcium concentration in endothelium of human umbilical vein endothelial cells -RSB- .
9010769	0	calcium	8,15	tumor_necrosis_factor-alpha	19,46	calcium	tumor necrosis factor-alpha	MESH:D002118	21926(Tax:10090)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|production production|amod|END_ENTITY	Role of calcium in tumor_necrosis_factor-alpha production by activated macrophages .
24376635	0	calcium	28,35	tumor_necrosis_factor_a	85,108	calcium	tumor necrosis factor a	MESH:D002118	21926(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	Estrogen-induced nongenomic calcium signaling inhibits lipopolysaccharide-stimulated tumor_necrosis_factor_a production in macrophages .
16447655	0	calcium	89,96	tumor_necrosis_factor_alpha	12,39	calcium	tumor necrosis factor alpha	MESH:D002118	24835(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	-LSB- Effects of tumor_necrosis_factor_alpha on expression of phospholamban and intracellular calcium in cardiomyocytes -RSB- .
15958728	0	calcium	56,63	tumor_protein	31,44	calcium	tumor protein	MESH:D002118	7178	Chemical	Gene	protein|compound|START_ENTITY protein|nsubj|END_ENTITY	The translationally controlled tumor_protein is a novel calcium binding protein of the human placenta and regulates calcium handling in trophoblast cells .
8931463	0	calcium	46,53	tyrosine_hydroxylase	71,91	calcium	tyrosine hydroxylase	MESH:D002118	25085(Tax:10116)	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|expression expression|amod|END_ENTITY	Involvement of intracellular or extracellular calcium in activation of tyrosine_hydroxylase gene expression in PC12 cells .
12878695	0	calcium	68,75	unc-2	48,53	calcium	unc-2	MESH:D002118	180570(Tax:6239)	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Critical residues of the Caenorhabditis_elegans unc-2 voltage-gated calcium channel that affect behavioral and physiological properties .
15458766	0	calcium	30,37	urocortin	10,19	calcium	urocortin	MESH:D002118	29151(Tax:10116)	Chemical	Gene	currents|compound|START_ENTITY Effect|nmod|currents Effect|nmod|END_ENTITY	Effect of urocortin on L-type calcium currents in adult rat ventricular myocytes .
18209484	0	calcium	23,30	urocortin	42,51	calcium	urocortin	MESH:D002118	29151(Tax:10116)	Chemical	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Enhanced intracellular calcium induced by urocortin is involved in degranulation of rat lung mast cells .
15363979	0	calcium	37,44	urotensin-II	16,28	calcium	urotensin-II	MESH:D002118	29180(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY release|amod|END_ENTITY	Urantide mimics urotensin-II induced calcium release in cells expressing recombinant UT receptors .
18314227	0	calcium	16,23	urotensin-II	40,52	calcium	urotensin-II	MESH:D002118	10911	Chemical	Gene	mobilization|compound|START_ENTITY mobilization|nmod|END_ENTITY	State-dependent calcium mobilization by urotensin-II in cultured human endothelial cells .
1082422	0	calcium	50,57	vasopressin	24,35	calcium	vasopressin	MESH:D002118	551	Chemical	Gene	contents|compound|START_ENTITY END_ENTITY|nmod|contents	Differential effects of vasopressin on the water , calcium and lysosomal enzyme contents of mitochondria-rich and lysosome-rich -LRB- granular -RRB- epithelial cells isolated from bullfrog urinary bladder .
15319442	0	calcium	171,178	vasopressin	33,44	calcium	vasopressin	MESH:D002118	551	Chemical	Gene	elevation|nmod|START_ENTITY eliminates|dobj|elevation interacts|parataxis|eliminates interacts|nmod|receptor receptor|compound|END_ENTITY	Calmodulin interacts with the V2 vasopressin receptor : elimination of binding to the C terminus also eliminates arginine_vasopressin-stimulated elevation of intracellular calcium .
17357383	0	calcium	73,80	vasopressin	11,22	calcium	vasopressin	MESH:D002118	551	Chemical	Gene	due|nmod|START_ENTITY blocker|amod|due setting|nmod|blocker END_ENTITY|nmod|setting	The use of vasopressin in the setting of recalcitrant hypotension due to calcium channel blocker overdose .
19549694	0	calcium	72,79	vasopressin	48,59	calcium	vasopressin	MESH:D002118	551	Chemical	Gene	sensing|compound|START_ENTITY sensing|compound|END_ENTITY	Osmomediated natriuresis in humans : the role of vasopressin and tubular calcium sensing .
2478133	0	calcium	32,39	vasopressin	78,89	calcium	vasopressin	MESH:D002118	551	Chemical	Gene	neuropeptides|dobj|START_ENTITY neuropeptides|parataxis|effects effects|nmod|END_ENTITY	Multiple neuropeptides mobilise calcium in small_cell_lung_cancer : effects of vasopressin , bradykinin , cholecystokinin , galanin and neurotensin .
2541621	0	calcium	25,32	vasopressin	61,72	calcium	vasopressin	MESH:D002118	396995(Tax:9823)	Chemical	Gene	Alterations|nmod|START_ENTITY induced|nsubj|Alterations induced|nmod|purines purines|compound|END_ENTITY	Alterations of cytosolic calcium in LLC-PK1 cells induced by vasopressin and exogenous purines .
2766658	0	calcium	24,31	vasopressin	72,83	calcium	vasopressin	MESH:D002118	551	Chemical	Gene	START_ENTITY|dep|responses responses|nmod|END_ENTITY	Platelet cytosolic free calcium in essential hypertension : responses to vasopressin .
4336157	0	calcium	39,46	vasopressin	10,21	calcium	vasopressin	MESH:D002118	551	Chemical	Gene	ions|compound|START_ENTITY uptake|nmod|ions END_ENTITY|nmod|uptake	Effect of vasopressin on the uptake of calcium ions by kidney mitochondria and on the concentration of adenosine_3 ' :5 ' - cyclic_monophosphate in toad bladder .
5898101	0	calcium	8,15	vasopressin	34,45	calcium	vasopressin	MESH:D002118	551	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|release release|nmod|END_ENTITY	Role of calcium in the release of vasopressin and oxytocin from posterior pituitary protein .
6385970	0	calcium	6,13	vasopressin	30,41	calcium	vasopressin	MESH:D002118	551	Chemical	Gene	mobilization|compound|START_ENTITY mobilization|nmod|END_ENTITY	Rapid calcium mobilization by vasopressin and prostaglandin_F2_alpha is independent of sodium influx in quiescent 3T3 cells .
6433890	0	calcium	29,36	vasopressin	89,100	calcium	vasopressin	MESH:D002118	551	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of cytoplasmic free calcium in the responses of quin2-loaded human platelets to vasopressin .
7969820	0	calcium	142,149	vasopressin	11,22	calcium	vasopressin	MESH:D002118	551	Chemical	Gene	channels|compound|START_ENTITY activation|nmod|channels stimulates|nmod|activation stimulates|nsubj|receptor receptor|compound|END_ENTITY	The cloned vasopressin V1a receptor stimulates phospholipase_A2 , phospholipase C , and phospholipase D through activation of receptor-operated calcium channels .
992028	0	calcium	22,29	vasopressin	47,58	calcium	vasopressin	MESH:D002118	551	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|action action|nmod|END_ENTITY	Role of extracellular calcium in the action of vasopressin on hepatic glycogenolysis .
11746268	0	calcium	138,145	vitamin_D_receptor	23,41	calcium	vitamin D receptor	MESH:D002118	22337(Tax:10090)	Chemical	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|modulator modulator|compound|END_ENTITY	Novel nonsecosteroidal vitamin_D_receptor modulator inhibits the growth of LNCaP xenograft tumors in athymic mice without increased serum calcium .
12018632	0	calcium	69,76	vitamin_D_receptor	16,34	calcium	vitamin D receptor	MESH:D002118	7421	Chemical	Gene	kidney_stones|compound|START_ENTITY patients|nmod|kidney_stones start|nmod|patients start|nsubj|Polymorphism Polymorphism|nmod|gene gene|compound|END_ENTITY	Polymorphism of vitamin_D_receptor gene start codon in patients with calcium kidney_stones .
12444213	0	calcium	73,80	vitamin_D_receptor	26,44	calcium	vitamin D receptor	MESH:D002118	24873(Tax:10116)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of parathyroid vitamin_D_receptor expression by extracellular calcium .
12854831	0	calcium	140,147	vitamin_D_receptor	83,101	calcium	vitamin D receptor	MESH:D002118	22337(Tax:10090)	Chemical	Gene	affecting|dobj|START_ENTITY regulates|advcl|affecting regulates|dobj|mineralization mineralization|nmod|mice mice|compound|END_ENTITY	Dietary calcium and phosphorus ratio regulates bone mineralization and turnover in vitamin_D_receptor knockout mice by affecting intestinal calcium and phosphorus absorption .
12854831	0	calcium	8,15	vitamin_D_receptor	83,101	calcium	vitamin D receptor	MESH:D002118	22337(Tax:10090)	Chemical	Gene	ratio|compound|START_ENTITY regulates|nsubj|ratio regulates|dobj|mineralization mineralization|nmod|mice mice|compound|END_ENTITY	Dietary calcium and phosphorus ratio regulates bone mineralization and turnover in vitamin_D_receptor knockout mice by affecting intestinal calcium and phosphorus absorption .
1333519	0	calcium	98,105	vitamin_D_receptor	35,53	calcium	vitamin D receptor	MESH:D002118	24873(Tax:10116)	Chemical	Gene	insensitive|advmod|START_ENTITY insensitive|nsubj|regulation regulation|nmod|END_ENTITY	Short-term regulation of the renal vitamin_D_receptor in rats by 1,25-dihydroxycholecalciferol is calcium insensitive .
14999525	0	calcium	105,112	vitamin_D_receptor	10,28	calcium	vitamin D receptor	MESH:D002118	7421	Chemical	Gene	relationship|nmod|START_ENTITY polymorphism|nmod|relationship polymorphism|nsubj|Effect Effect|nmod|gene gene|compound|END_ENTITY	Effect of vitamin_D_receptor and estrogen_receptor gene polymorphism on the relationship between dietary calcium and bone_mineral_density in Japanese women .
15205858	0	calcium	49,56	vitamin_D_receptor	15,33	calcium	vitamin D receptor	MESH:D002118	7421	Chemical	Gene	excretion|compound|START_ENTITY genotypes|nmod|excretion genotypes|nsubj|Association Association|nmod|END_ENTITY	Association of vitamin_D_receptor genotypes with calcium excretion in nephrolithiatic subjects in northern India .
15456794	0	calcium	35,42	vitamin_D_receptor	85,103	calcium	vitamin D receptor	MESH:D002118	22337(Tax:10090)	Chemical	Gene	calbindin-D28k|nmod|START_ENTITY homeostasis|amod|calbindin-D28k role|nmod|homeostasis revealed|nsubj|role revealed|nmod|mice mice|acl|lacking lacking|xcomp|END_ENTITY	Critical role of calbindin-D28k in calcium homeostasis revealed by mice lacking both vitamin_D_receptor and calbindin-D28k .
1665280	0	calcium	59,66	vitamin_D_receptor	112,130	calcium	vitamin D receptor	MESH:D002118	24873(Tax:10116)	Chemical	Gene	increases|dobj|START_ENTITY increases|nmod|cells cells|acl|lacking lacking|dobj|END_ENTITY	1 Alpha,25-dihydroxyvitamin _ D3 rapidly increases cytosolic calcium in clonal rat osteosarcoma cells lacking the vitamin_D_receptor .
17419705	0	calcium	89,96	vitamin_D_receptor	15,33	calcium	vitamin D receptor	MESH:D002118	7421	Chemical	Gene	urolithiasis|compound|START_ENTITY presentation|nmod|urolithiasis polymorphism|nmod|presentation polymorphism|nsubj|Association Association|nmod|END_ENTITY	Association of vitamin_D_receptor -LRB- Fok-I -RRB- polymorphism with the clinical presentation of calcium urolithiasis .
18327873	0	calcium	12,19	vitamin_D_receptor	52,70	calcium	vitamin D receptor	MESH:D002118	7421	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|genes genes|compound|END_ENTITY	Nutritional calcium modulates colonic expression of vitamin_D_receptor and pregnane_X_receptor target genes .
18353900	0	calcium	62,69	vitamin_D_receptor	4,22	calcium	vitamin D receptor	MESH:D002118	7421	Chemical	Gene	activity|compound|START_ENTITY upregulates|dobj|activity upregulates|nsubj|elocalcitol elocalcitol|compound|END_ENTITY	The vitamin_D_receptor agonist elocalcitol upregulates L-type calcium channel activity in human and rat bladder .
19254681	0	calcium	53,60	vitamin_D_receptor	11,29	calcium	vitamin D receptor	MESH:D002118	22337(Tax:10090)	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Intestinal vitamin_D_receptor is required for normal calcium and bone metabolism in mice .
19631778	0	calcium	24,31	vitamin_D_receptor	60,78	calcium	vitamin D receptor	MESH:D002118	22337(Tax:10090)	Chemical	Gene	Improvement|nmod|START_ENTITY homeostasis|nsubj|Improvement homeostasis|nmod|mice mice|compound|END_ENTITY	Improvement of impaired calcium and skeletal homeostasis in vitamin_D_receptor knockout mice by a high dose of calcitriol and maxacalcitol .
19690432	0	calcium	109,116	vitamin_D_receptor	16,34	calcium	vitamin D receptor	MESH:D002118	7421	Chemical	Gene	homeostasis|compound|START_ENTITY Associations|nmod|homeostasis Associations|nmod|polymorphisms polymorphisms|compound|END_ENTITY	Associations of vitamin_D_receptor , calcium-sensing_receptor and parathyroid_hormone gene polymorphisms with calcium homeostasis and peripheral bone density in adult Finns .
20051486	0	calcium	34,41	vitamin_D_receptor	102,120	calcium	vitamin D receptor	MESH:D002118	22337(Tax:10090)	Chemical	Gene	absorption|compound|START_ENTITY absorption|nmod|END_ENTITY	Pregnancy up-regulates intestinal calcium absorption and skeletal mineralization independently of the vitamin_D_receptor .
21115334	0	calcium	117,124	vitamin_D_receptor	12,30	calcium	vitamin D receptor	MESH:D002118	7421	Chemical	Gene	intake|compound|START_ENTITY polymorphisms|nmod|intake polymorphisms|nsubj|role role|nmod|gene gene|compound|END_ENTITY	The role of vitamin_D_receptor gene polymorphisms in the bone_mineral_density of Greek postmenopausal women with low calcium intake .
21887707	0	calcium	102,109	vitamin_D_receptor	83,101	calcium	vitamin D receptor	MESH:D002118	7421	Chemical	Gene	genotype|compound|START_ENTITY genotype|compound|END_ENTITY	Calcium intake and prostate_cancer among African Americans : effect modification by vitamin_D_receptor calcium absorption genotype .
25000366	0	calcium	67,74	vitamin_D_receptor	15,33	calcium	vitamin D receptor	MESH:D002118	7421	Chemical	Gene	level|compound|START_ENTITY polymorphism|nmod|level polymorphism|nsubj|Association Association|nmod|gene gene|compound|END_ENTITY	Association of vitamin_D_receptor gene polymorphism with the urine calcium level in nephrolithiasis patients .
25823394	0	calcium	8,15	vitamin_D_receptor	165,183	calcium	vitamin D receptor	MESH:D002118	24873(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY __|nsubj|Role __|nmod|cells cells|nmod|END_ENTITY	Role of calcium in the regulation of bone_morphogenetic_protein __ 2 , runt-related_transcription_factor_2 and Osterix in primary renal tubular epithelial cells by the vitamin_D_receptor .
2839546	0	calcium	86,93	vitamin_D_receptor	52,70	calcium	vitamin D receptor	MESH:D002118	24873(Tax:10116)	Chemical	Gene	restriction|compound|START_ENTITY END_ENTITY|nmod|restriction	Evidence for in vivo upregulation of the intestinal vitamin_D_receptor during dietary calcium restriction in the rat .
7895652	0	calcium	13,20	vitamin_D_receptor	71,89	calcium	vitamin D receptor	MESH:D002118	24873(Tax:10116)	Chemical	Gene	D3|compound|START_ENTITY D3|nmod|regulation regulation|nmod|expression expression|compound|END_ENTITY	The roles of calcium and 1,25-dihydroxyvitamin _ D3 in the regulation of vitamin_D_receptor expression by rat parathyroid glands .
8385999	0	calcium	285,292	vitamin_D_receptor	46,64	calcium	vitamin D receptor	MESH:D002118	24873(Tax:10116)	Chemical	Gene	supplementation|compound|START_ENTITY conditions|nmod|supplementation analyzed|nmod|conditions analyzed|nsubj|necessity necessity|nmod|calcium calcium|nmod|END_ENTITY	The necessity for calcium for increased renal vitamin_D_receptor in response to 1,25-dihydroxyvitamin _ D. To further investigate the regulation of the vitamin_D_receptor in the kidney of the rat , we analyzed the response of the receptor to 1,25-dihydroxyvitamin _ D-3 under conditions of calcium supplementation and calcium restriction .
8529012	0	calcium	61,68	vitamin_D_receptor	27,45	calcium	vitamin D receptor	MESH:D002118	395988(Tax:9031)	Chemical	Gene	transport|compound|START_ENTITY transport|compound|END_ENTITY	Differential regulation of vitamin_D_receptor and intestinal calcium transport occurring during sexual maturation in the fowl -LRB- Gallus_domesticus -RRB- .
8530616	0	calcium	35,42	vitamin_D_receptor	66,84	calcium	vitamin D receptor	MESH:D002118	7421	Chemical	Gene	absorption|nmod|START_ENTITY intakes|nsubj|absorption intakes|nmod|genotype genotype|compound|END_ENTITY	Calcium absorption on high and low calcium intakes in relation to vitamin_D_receptor genotype .
9062532	0	calcium	18,25	vitamin_D_receptor	67,85	calcium	vitamin D receptor	MESH:D002118	7421	Chemical	Gene	intake|compound|START_ENTITY Relations|nmod|intake Relations|appos|polymorphisms polymorphisms|nmod|gene gene|compound|END_ENTITY	Relations between calcium intake , calcitriol , polymorphisms of the vitamin_D_receptor gene , and calcium absorption in premenopausal women .
9164821	0	calcium	42,49	vitamin_D_receptor	10,28	calcium	vitamin D receptor	MESH:D002118	7421	Chemical	Gene	absorption|compound|START_ENTITY genotypes|nmod|absorption genotypes|compound|END_ENTITY	Effect of vitamin_D_receptor genotypes on calcium absorption , duodenal vitamin_D_receptor concentration , and serum 1,25 dihydroxyvitamin_D levels in normal women .
9200004	0	calcium	99,106	vitamin_D_receptor	9,27	calcium	vitamin D receptor	MESH:D002118	7421	Chemical	Gene	intake|compound|START_ENTITY effect|nmod|intake influences|dobj|effect influences|nsubj|polymorphism polymorphism|compound|END_ENTITY	The BsmI vitamin_D_receptor restriction fragment length polymorphism -LRB- bb -RRB- influences the effect of calcium intake on bone_mineral_density .
9528970	0	calcium	105,112	vitamin_D_receptor	40,58	calcium	vitamin D receptor	MESH:D002118	24873(Tax:10116)	Chemical	Gene	intestine|nmod|START_ENTITY regulation|nmod|intestine regulation|nmod|END_ENTITY	Distinct , tissue-specific regulation of vitamin_D_receptor in the intestine , kidney , and skin by dietary calcium and vitamin_D .
24981232	0	calcium-activated_chloride	78,104	TMEM16A	70,77	calcium-activated chloride	TMEM16A	null	101772(Tax:10090)	Chemical	Gene	channel|amod|START_ENTITY channel|compound|END_ENTITY	Calcium-calmodulin does not alter the anion permeability of the mouse TMEM16A calcium-activated_chloride channel .
23490272	0	calcium-phosphate	44,61	FGF-23	16,22	calcium-phosphate	FGF-23	MESH:C020243	8074	Chemical	Gene	metabolism|amod|START_ENTITY Effect|nmod|metabolism Effect|nmod|END_ENTITY	Effect of serum FGF-23 , MGP and fetuin-A on calcium-phosphate metabolism in maintenance_hemodialysis patients .
760393	0	calcium_carbonate	33,50	gastrin	84,91	calcium carbonate	gastrin	MESH:D002119	2520	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|concentration concentration|compound|END_ENTITY	Effect of oral administration of calcium_carbonate , Camalox and Novalucol on plasma gastrin concentration in duodenal ulcer patients .
16196291	0	calcium_dobesilate	11,29	TIMP1	44,49	calcium dobesilate	TIMP1	MESH:D002123	116510(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of calcium_dobesilate on glomerulus TIMP1 and collagen IV of diabetic rats .
830778	0	calcium_gluconate	10,27	renin	40,45	calcium gluconate	renin	MESH:D002125	403838(Tax:9615)	Chemical	Gene	infusion|amod|START_ENTITY Effect|nmod|infusion Effect|nmod|END_ENTITY	Effect of calcium_gluconate infusion on renin in the dog .
22830991	0	calcium_gluconate	28,45	transforming_growth_factor_beta_1	79,112	calcium gluconate	transforming growth factor beta 1	MESH:D002125	403998(Tax:9615)	Chemical	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	Comparison of the effect of calcium_gluconate and batroxobin on the release of transforming_growth_factor_beta_1 in canine platelet concentrates .
23131192	0	calcium_gluconate	28,45	transforming_growth_factor_beta_1	93,126	calcium gluconate	transforming growth factor beta 1	MESH:D002125	282089(Tax:9913)	Chemical	Gene	thrombin|amod|START_ENTITY thrombin|nmod|release release|nmod|END_ENTITY	Evaluation of the effect of calcium_gluconate and bovine thrombin on the temporal release of transforming_growth_factor_beta_1 and platelet-derived growth factor isoform BB from feline platelet concentrates .
27063305	0	calcium_hydroxide	15,32	IL-6	36,40	calcium hydroxide	IL-6	MESH:D002126	3569	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	-LSB- The effect of calcium_hydroxide on IL-6 and TNF-a expression of osteoblast in periapical tissues -RSB- .
11307460	0	calcium_hydroxide	41,58	TGF-beta_1	0,10	calcium hydroxide	TGF-beta 1	MESH:D002126	59086(Tax:10116)	Chemical	Gene	combination|nmod|START_ENTITY combination|amod|END_ENTITY	TGF-beta_1 alone and in combination with calcium_hydroxide is synergistic to TGF-beta_1 production by osteoblasts in vitro .
12637633	0	calcium_oxalate	119,134	MCP-1	60,65	calcium oxalate	MCP-1	MESH:D002129	24770(Tax:10116)	Chemical	Gene	exposure|acl|START_ENTITY expression|nmod|exposure expression|nmod|END_ENTITY	Increased expression of monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- by renal epithelial cells in culture on exposure to calcium_oxalate , phosphate and uric_acid crystals .
16397773	0	calcium_oxalate	33,48	MCP-1	79,84	calcium oxalate	MCP-1	MESH:D002129	6347	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Reactive oxygen species mediated calcium_oxalate crystal-induced expression of MCP-1 in HK-2 cells .
19376000	0	calcium_phosphate	58,75	alkaline_phosphatase	37,57	calcium phosphate	alkaline phosphatase	MESH:C020243	250	Chemical	Gene	START_ENTITY|nmod|responses responses|nmod|END_ENTITY	In vitro responses to electrosprayed alkaline_phosphatase / calcium_phosphate composite coatings .
18223264	0	calcium_phosphate	19,36	matrix_metalloproteinase-13	56,83	calcium phosphate	matrix metalloproteinase-13	MESH:C020243	4322	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Mechanism of basic calcium_phosphate crystal-stimulated matrix_metalloproteinase-13 expression by osteoarthritic synovial fibroblasts : inhibition by prostaglandin_E2 .
7615968	0	calcium_phosphate	46,63	osteopontin	17,28	calcium phosphate	osteopontin	MESH:C020243	6696	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Possible role of osteopontin in deposition of calcium_phosphate in human pilomatricomas .
16436294	0	calcium_phosphate	80,97	thrombin	52,60	calcium phosphate	thrombin	MESH:C020243	14061(Tax:10090)	Chemical	Gene	ceramic|compound|START_ENTITY coated|nmod|ceramic coated|nsubj|modulation modulation|nmod|expression expression|nmod|osteoblasts osteoblasts|nmod|END_ENTITY	The modulation of gene expression in osteoblasts by thrombin coated on biphasic calcium_phosphate ceramic .
968810	0	calcium_phosphate	10,27	thrombin	31,39	calcium phosphate	thrombin	MESH:C020243	2147	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of calcium_phosphate on thrombin and on its sensitivity to heparin and antithrombin-III .
12180739	0	calcium_pyrophosphate_dihydrate	51,82	Cartilage_intermediate_layer_protein	0,36	calcium pyrophosphate dihydrate	Cartilage intermediate layer protein	MESH:D002131	8483	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Cartilage_intermediate_layer_protein expression in calcium_pyrophosphate_dihydrate crystal_deposition_disease .
10524685	0	calcium_pyrophosphate_dihydrate	89,120	cartilage_intermediate_layer_protein	32,68	calcium pyrophosphate dihydrate	cartilage intermediate layer protein	MESH:D002131	8483	Chemical	Gene	syndromes|amod|START_ENTITY mapped|dobj|syndromes mapped|nsubj|Exclusion Exclusion|nmod|gene gene|nmod|END_ENTITY	Exclusion of the gene for human cartilage_intermediate_layer_protein in currently mapped calcium_pyrophosphate_dihydrate deposition syndromes .
18362727	0	calcium_sulfate	35,50	bone_morphogenetic_protein_2	90,118	calcium sulfate	bone morphogenetic protein 2	MESH:D002133	650	Chemical	Gene	pellet|amod|START_ENTITY pressed|dobj|pellet pressed|advcl|END_ENTITY	Effects of chitosan-coated pressed calcium_sulfate pellet combined with recombinant human bone_morphogenetic_protein_2 on restoration of segmental bone defect .
20098183	0	calcium_sulfate	35,50	bone_morphogenetic_protein_2	91,119	calcium sulfate	bone morphogenetic protein 2	MESH:D002133	650	Chemical	Gene	pellets|amod|START_ENTITY pressed|dobj|pellets pressed|advcl|END_ENTITY	Effects of chitosan-coated pressed calcium_sulfate pellets combined with recombinant human bone_morphogenetic_protein_2 on bone formation in femoral condyle-contained bone defects .
8537344	3	caldariellaquinone	163,181	oxidoreductase	182,196	caldariellaquinone	oxidoreductase	MESH:C014380	1458782(Tax:273063)	Chemical	Gene	complex|amod|START_ENTITY complex|compound|END_ENTITY	The archaeal novel respiratory complex II -LRB- succinate : caldariellaquinone oxidoreductase complex -RRB- inherently lacks heme group .
8861945	0	calmodulin	44,54	receptor-associated_protein	4,31	calmodulin	receptor-associated protein	null	4043	Chemical	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	The receptor-associated_protein -LRB- RAP -RRB- binds calmodulin and is phosphorylated by calmodulin-dependent kinase II .
8250833	0	calpastatin	65,76	m-calpain	30,39	calpastatin	m-calpain	null	824	Chemical	Gene	Studies|nmod|START_ENTITY Studies|nmod|site site|nmod|END_ENTITY	Studies of the active site of m-calpain and the interaction with calpastatin .
1386868	0	calphobindins	23,36	phospholipase_A2	40,56	calphobindins	phospholipase A2	null	151056	Chemical	Gene	START_ENTITY|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Inhibitory effects of calphobindins on phospholipase_A2 and phospholipase C -RSB- .
9143362	0	calphostin	84,94	phospholipase_D	36,51	calphostin	phospholipase D	MESH:C061465	2822	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of GTP gamma S-dependent phospholipase_D and Rho membrane association by calphostin is independent of protein_kinase_C catalytic activity .
7632168	0	calphostin_C	59,71	diacylglycerol_kinase	14,35	calphostin C	diacylglycerol kinase	MESH:C058819	1607	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of diacylglycerol_kinase by the antitumor agent calphostin_C .
14726309	0	calponin	55,63	PKC-alpha	40,49	calponin	PKC-alpha	null	5578	Chemical	Gene	association|nmod|START_ENTITY association|nmod|END_ENTITY	Direct association and translocation of PKC-alpha with calponin .
18948438	0	calponin	22,30	PKC-alpha	56,65	calponin	PKC-alpha	null	5578	Chemical	Gene	association|nmod|START_ENTITY association|nmod|END_ENTITY	Direct association of calponin with specific domains of PKC-alpha .
15295644	0	calponin	29,37	myosin	55,61	calponin	myosin	null	79784	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of trace amount of calponin on smooth muscle myosin in different states .
2150518	0	calponin	10,18	myosin	38,44	calponin	myosin	null	79784	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|compound|END_ENTITY	Effect of calponin on actin-activated myosin ATPase activity .
8370658	0	calponin	22,30	myosin	34,40	calponin	myosin	null	79784	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|amod|END_ENTITY	Stimulatory effect of calponin on myosin ATPase activity .
19755969	0	calprotectin	6,18	CRP	110,113	calprotectin	CRP	MESH:D039841	1401	Chemical	Gene	correlates|nsubj|START_ENTITY correlates|nmod|END_ENTITY	Fecal calprotectin correlates more closely with the Simple_Endoscopic_Score_for_Crohn 's _ disease -LRB- SES-CD -RRB- than CRP , blood leukocytes , and the CDAI .
2277863	0	calvatic_acid	10,23	ornithine_decarboxylase	43,66	calvatic acid	ornithine decarboxylase	MESH:C010057	4953	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	Effect of calvatic_acid and its analogs on ornithine_decarboxylase activity in tumour cells .
24548484	0	calycosin	82,91	RASD1	14,19	calycosin	RASD1	MESH:C121707	64455(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY involved|nmod|effects involved|nsubjpass|END_ENTITY	Downregulated RASD1 and upregulated miR-375 are involved in protective effects of calycosin on cerebral_ischemia / reperfusion rats .
9038140	0	calyculin_A	43,54	IkappaBbeta	84,95	calyculin A	IkappaBbeta	MESH:C059041	4793	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|degradation degradation|nmod|END_ENTITY	The serine/threonine phosphatase inhibitor calyculin_A induces rapid degradation of IkappaBbeta .
11113637	0	calyculin_A	39,50	PP1	206,209	calyculin A	PP1	MESH:C059041	5464	Chemical	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	A study of the binding requirements of calyculin_A and dephosphonocalyculin_A with PP1 , development of a molecular recognition model for the binding interactions of the okadaic acid class of compounds with PP1 .
11113637	0	calyculin_A	39,50	PP1	83,86	calyculin A	PP1	MESH:C059041	5464	Chemical	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	A study of the binding requirements of calyculin_A and dephosphonocalyculin_A with PP1 , development of a molecular recognition model for the binding interactions of the okadaic acid class of compounds with PP1 .
20161975	0	calyculin_A	134,145	PP1	87,90	calyculin A	PP1	MESH:C059041	5464	Chemical	Gene	syntheses|nmod|START_ENTITY polyketides|compound|syntheses polyketides|compound|END_ENTITY	Calyculins and related marine natural products as serine-threonine protein phosphatase PP1 and PP2A inhibitors and total syntheses of calyculin_A , B , and C. Calyculins , highly cytotoxic polyketides , originally isolated from the marine sponge Discodermia calyx by Fusetani and co-workers , belong to the lithistid sponges group .
20161975	0	calyculin_A	134,145	PP2A	95,99	calyculin A	PP2A	MESH:C059041	5524	Chemical	Gene	syntheses|nmod|START_ENTITY polyketides|compound|syntheses polyketides|compound|END_ENTITY	Calyculins and related marine natural products as serine-threonine protein phosphatase PP1 and PP2A inhibitors and total syntheses of calyculin_A , B , and C. Calyculins , highly cytotoxic polyketides , originally isolated from the marine sponge Discodermia calyx by Fusetani and co-workers , belong to the lithistid sponges group .
9815125	0	calyculin_A	21,32	renin	85,90	calyculin A	renin	MESH:C059041	5972	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|compound|END_ENTITY	Inhibitory effect of calyculin_A , a Ser/Thr protein phosphatase type I inhibitor , on renin secretion .
11484915	0	camostat_mesilate	10,27	pancreatitis-associated_protein	49,80	camostat mesilate	pancreatitis-associated protein	MESH:C034532	24618(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	Effect of camostat_mesilate on the expression of pancreatitis-associated_protein -LRB- PAP -RRB- , p8 , and cytokines in rat spontaneous chronic_pancreatitis .
2467043	0	camostate	62,71	phospholipase_A2	23,39	camostate	phospholipase A2	MESH:C034532	151056	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	In vitro inhibition of phospholipase_A2 by gabexate_mesilate , camostate , and aprotinine .
3342468	0	camptothecin	48,60	CPT-11	20,26	camptothecin	CPT-11	MESH:D002166	963084(Tax:115711)	Chemical	Gene	derivative|nmod|START_ENTITY effect|appos|derivative effect|nmod|END_ENTITY	Antitumor effect of CPT-11 , a new derivative of camptothecin , against pleiotropic_drug-resistant_tumors in vitro and in vivo .
9750028	0	camptothecin	53,65	CPT-11	89,95	camptothecin	CPT-11	MESH:D002166	963084(Tax:115711)	Chemical	Gene	irinotecan|amod|START_ENTITY irinotecan|appos|END_ENTITY	Multiplicity of biliary excretion mechanisms for the camptothecin derivative irinotecan -LRB- CPT-11 -RRB- , its metabolite SN-38 , and its glucuronide : role of canalicular_multispecific_organic_anion_transporter and P-glycoprotein .
18708040	0	camptothecin	62,74	CPT13	47,52	camptothecin	CPT13	MESH:D002166	963077(Tax:115711)	Chemical	Gene	analog|compound|START_ENTITY effect|appos|analog effect|nmod|END_ENTITY	Anti-proliferative and pro-apoptotic effect of CPT13 , a novel camptothecin analog , on human colon_cancer HCT8 cell line .
8707853	0	camptothecin	35,47	DNA_topoisomerase-I	65,84	camptothecin	DNA topoisomerase-I	MESH:D002166	64550(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Induction of neuronal apoptosis by camptothecin , an inhibitor of DNA_topoisomerase-I : evidence for cell cycle-independent toxicity .
24252850	0	camptothecin	46,58	HIF-1a	70,76	camptothecin	HIF-1a	MESH:D002166	3091	Chemical	Gene	activity|dep|START_ENTITY activity|compound|END_ENTITY	The natural inhibitor of DNA topoisomerase I , camptothecin , modulates HIF-1a activity by changing miR expression patterns in human cancer cells .
10066793	0	camptothecin	97,109	TRF4	40,44	camptothecin	TRF4	MESH:D002166	11044	Chemical	Gene	affects|nmod|START_ENTITY affects|nsubj|END_ENTITY	The topoisomerase-related function gene TRF4 affects cellular sensitivity to the antitumor agent camptothecin .
21619602	0	camptothecin	64,76	Topoisomerase_I	4,19	camptothecin	Topoisomerase I	MESH:D002166	7150	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|mutations mutations|compound|END_ENTITY	New Topoisomerase_I mutations are associated with resistance to camptothecin .
25539742	0	camptothecin	81,93	Y-box_binding_protein_1	0,23	camptothecin	Y-box binding protein 1	MESH:D002166	4904	Chemical	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	Y-box_binding_protein_1 enhances DNA topoisomerase 1 activity and sensitivity to camptothecin via direct interaction .
8099964	0	camptothecin	23,35	acetylcholinesterase	56,76	camptothecin	acetylcholinesterase	MESH:D002166	489828(Tax:9615)	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	Inhibitory activity of camptothecin derivatives against acetylcholinesterase in dogs and their binding activity to acetylcholine receptors in rats .
11877436	0	camptothecin	81,93	p21	8,11	camptothecin	p21	MESH:D002166	644914	Chemical	Gene	treated|nmod|START_ENTITY Role|acl|treated Role|nmod|END_ENTITY	Role of p21 in apoptosis and senescence of human colon_cancer cells treated with camptothecin .
11313933	0	camptothecin	86,98	p53	102,105	camptothecin	p53	MESH:D002166	7157	Chemical	Gene	START_ENTITY|nmod|cells cells|nummod|END_ENTITY	Activation of the Fas pathway independently of Fas_ligand during apoptosis induced by camptothecin in p53 mutant human colon_carcinoma cells .
11118036	0	camptothecin	20,32	topoisomerase_I	103,118	camptothecin	topoisomerase I	MESH:D002166	21969(Tax:10090)	Chemical	Gene	analogue|compound|START_ENTITY Activity|nmod|analogue Activity|nmod|alterations alterations|amod|END_ENTITY	Activity of a novel camptothecin analogue , homocamptothecin , in camptothecin-resistant cell lines with topoisomerase_I alterations .
11479235	0	camptothecin	94,106	topoisomerase_I	49,64	camptothecin	topoisomerase I	MESH:D002166	7150	Chemical	Gene	degradation|acl|START_ENTITY degradation|nmod|END_ENTITY	Ubiquitin/26S proteasome-mediated degradation of topoisomerase_I as a resistance mechanism to camptothecin in tumor cells .
11814334	0	camptothecin	42,54	topoisomerase_I	6,21	camptothecin	topoisomerase I	MESH:D002166	7150	Chemical	Gene	inhibition|dep|START_ENTITY inhibition|compound|END_ENTITY	Human topoisomerase_I inhibition : docking camptothecin and derivatives into a structure-based active site model .
12149243	0	camptothecin	142,154	topoisomerase_I	15,30	camptothecin	topoisomerase I	MESH:D002166	7150	Chemical	Gene	involved|nmod|START_ENTITY involved|nsubjpass|Sumoylation Sumoylation|nmod|END_ENTITY	Sumoylation of topoisomerase_I is involved in its partitioning between nucleoli and nucleoplasm and its clearing from nucleoli in response to camptothecin .
15916431	0	camptothecin	84,96	topoisomerase_I	26,41	camptothecin	topoisomerase I	MESH:D002166	7150	Chemical	Gene	relationships|compound|START_ENTITY comparison|nmod|relationships determinants|dep|comparison determinants|nmod|poisoning poisoning|amod|END_ENTITY	Molecular determinants of topoisomerase_I poisoning by lamellarins : comparison with camptothecin and structure-activity relationships .
16268636	0	camptothecin	34,46	topoisomerase_I	50,65	camptothecin	topoisomerase I	MESH:D002166	7150	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|amod|END_ENTITY	Effect of E-ring modifications in camptothecin on topoisomerase_I inhibition : a quantum mechanics treatment .
3031452	0	camptothecin	134,146	topoisomerase_I	25,40	camptothecin	topoisomerase I	MESH:D002166	32458(Tax:7227)	Chemical	Gene	using|dobj|START_ENTITY interactions|advcl|using interactions|nsubj|Localization Localization|nmod|END_ENTITY	Localization of specific topoisomerase_I interactions within the transcribed region of active heat_shock genes by using the inhibitor camptothecin .
7538195	0	camptothecin	113,125	topoisomerase_I	74,89	camptothecin	topoisomerase I	MESH:D002166	7150	Chemical	Gene	activity|compound|START_ENTITY induction|nmod|activity induction|nmod|END_ENTITY	Camptothecin induction of a time - and concentration-dependent decrease of topoisomerase_I and its implication in camptothecin activity .
7565862	0	camptothecin	71,83	topoisomerase_I	43,58	camptothecin	topoisomerase I	MESH:D002166	534799(Tax:9913)	Chemical	Gene	inhibitors|amod|START_ENTITY effects|nmod|inhibitors activity|dep|effects activity|nmod|END_ENTITY	DNA recombinase activity of eukaryotic DNA topoisomerase_I ; effects of camptothecin and other inhibitors .
8967967	0	camptothecin	9,21	topoisomerase_I	83,98	camptothecin	topoisomerase I	MESH:D002166	7150	Chemical	Gene	resistance|compound|START_ENTITY resistance|dep|cells cells|nmod|END_ENTITY	Acquired camptothecin resistance of human breast_cancer MCF-7 / C4 cells with normal topoisomerase_I and elevated DNA repair .
9305865	0	camptothecin	87,99	topoisomerase_I	35,50	camptothecin	topoisomerase I	MESH:D002166	7150	Chemical	Gene	stimulated|nmod|START_ENTITY stimulated|nsubjpass|destruction destruction|nmod|END_ENTITY	Ubiquitin-dependent destruction of topoisomerase_I is stimulated by the antitumor drug camptothecin .
22548646	0	canagliflozin	10,23	SGLT2	60,65	canagliflozin	SGLT2	MESH:C552334	6524	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|appos|END_ENTITY	Effect of canagliflozin , a sodium_glucose co-transporter 2 -LRB- SGLT2 -RRB- inhibitor , on bacteriuria and urinary_tract_infection in subjects with type 2 diabetes enrolled in a 12-week , phase 2 study .
24025022	0	canagliflozin	56,69	SGLT2	33,38	canagliflozin	SGLT2	MESH:C552334	6524	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|co-transporter co-transporter|appos|END_ENTITY	Sodium_glucose co-transporter 2 -LRB- SGLT2 -RRB- inhibition with canagliflozin in type_2_diabetes_mellitus .
25365416	0	canagliflozin	69,82	SGLT2	42,47	canagliflozin	SGLT2	MESH:C552334	6524	Chemical	Gene	focus|nmod|START_ENTITY status|dep|focus status|nmod|inhibitors inhibitors|nummod|END_ENTITY	Efficacy , safety and regulatory status of SGLT2 inhibitors : focus on canagliflozin .
25805666	4	canagliflozin	627,640	SGLT2	554,559	canagliflozin	SGLT2	MESH:C552334	6524	Chemical	Gene	empagliflozin|dep|START_ENTITY countries|appos|empagliflozin available|nmod|countries available|nsubj|inhibitors inhibitors|compound|END_ENTITY	Several SGLT2 inhibitors are already available in many countries -LRB- dapagliflozin , canagliflozin , empagliflozin -RRB- and in Japan -LRB- ipragliflozin , tofogliflozin -RRB- .
26609242	0	canagliflozin	106,119	SGLT2	0,5	canagliflozin	SGLT2	MESH:C552334	6524	Chemical	Gene	focus|nmod|START_ENTITY inhibitors|dep|focus inhibitors|nummod|END_ENTITY	SGLT2 inhibitors - an insulin-independent therapeutic approach for treatment of type 2 diabetes : focus on canagliflozin .
11115897	1	canavanine	127,137	AtUBP1_and_2	57,69	canavanine	AtUBP1 and 2	CHEBI:609827	817839;839397	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	AtUBP1_and_2 are required for the resistance to the amino_acid analog canavanine .
18188164	0	candesartan	53,64	ACE	94,97	candesartan	ACE	MESH:C081643	1636	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|compound|END_ENTITY	Pulse pressure lowering effect of dual blockade with candesartan and lisinopril vs. high-dose ACE inhibition in hypertensive_type_2 diabetic subjects : a CALM II study post-hoc analysis .
11399656	5	candesartan	776,787	ANG	680,683	candesartan	ANG	MESH:C081643	283	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|activation activation|compound|END_ENTITY	ANG II-mediated GFAT promoter activation was inhibited by the ANG II type I receptor antagonist candesartan -LRB- 10 -LRB- -8 -RRB- M -RRB- but was unaffected by the ANG II type II receptor antagonist PD-123319 -LRB- 10 -LRB- -8 -RRB- M -RRB- .
9663812	0	candesartan	63,74	Angiotensin_II	0,14	candesartan	Angiotensin II	MESH:C081643	183	Chemical	Gene	antagonism|nmod|START_ENTITY antagonism|compound|END_ENTITY	Angiotensin_II antagonism and plasma radioreceptor-kinetics of candesartan in man .
16675585	0	candesartan	42,53	Angiotensin_II_type_1_receptor	0,30	candesartan	Angiotensin II type 1 receptor	MESH:C081643	11610(Tax:10090)	Chemical	Gene	antagonist|dobj|START_ENTITY antagonist|nsubj|END_ENTITY	Angiotensin_II_type_1_receptor antagonist candesartan as an angiogenic inhibitor in a xenograft model of bladder_cancer .
9700985	0	candesartan	45,56	Angiotensin_II_type_1_receptor	0,30	candesartan	Angiotensin II type 1 receptor	MESH:C081643	100519976	Chemical	Gene	blockade|nmod|START_ENTITY blockade|amod|END_ENTITY	Angiotensin_II_type_1_receptor blockade with candesartan protects the porcine myocardium from reperfusion-induced injury .
15454852	0	candesartan	21,32	CD40	53,57	candesartan	CD40	MESH:C081643	21939(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|compound|END_ENTITY	Inhibitory effect of candesartan and rosuvastatin on CD40 and MMPs expression in apo-E knockout mice : novel insights into the role of RAS and dyslipidemia in atherogenesis .
20979831	0	candesartan	12,23	JAK2	42,46	candesartan	JAK2	MESH:C081643	24514(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expressions expressions|nmod|END_ENTITY	-LSB- Effects of candesartan on expressions of JAK2 and PTP-1B in adipose tissue of high-fat diet-fed rats -RSB- .
19760950	0	candesartan	53,64	angiotensin-II	13,27	candesartan	angiotensin-II	MESH:C081643	183	Chemical	Gene	blocker|appos|START_ENTITY blocker|amod|END_ENTITY	Effect of an angiotensin-II type-1 receptor blocker , candesartan on hepatic_fibrosis in chronic hepatitis_C : a prospective study .
14586718	0	candesartan	57,68	angiotensin-converting_enzyme	84,113	candesartan	angiotensin-converting enzyme	MESH:C081643	1636	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Effects of the angiotensin_II_type_1_receptor antagonist candesartan , compared with angiotensin-converting_enzyme inhibitors , on the urinary excretion of albumin and type IV collagen in patients with diabetic_nephropathy .
16644319	0	candesartan	94,105	angiotensin-converting_enzyme	35,64	candesartan	angiotensin-converting enzyme	MESH:C081643	1636	Chemical	Gene	benefits|nmod|START_ENTITY inhibitor|nmod|benefits inhibitor|amod|END_ENTITY	Relationship of dose of background angiotensin-converting_enzyme inhibitor to the benefits of candesartan in the Candesartan in Heart failure : Assessment of Reduction in Mortality and morbidity -LRB- CHARM -RRB- - Added trial .
10076924	0	candesartan	49,60	angiotensin_II	13,27	candesartan	angiotensin II	MESH:C081643	183	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Effect of an angiotensin_II receptor antagonist , candesartan , on insulin resistance and pressor mechanisms in essential hypertension .
10882779	0	candesartan	82,93	angiotensin_II	41,55	candesartan	angiotensin II	MESH:C081643	183	Chemical	Gene	blocks|compound|START_ENTITY blocks|amod|END_ENTITY	Chronic peripheral administration of the angiotensin_II AT -LRB- 1 -RRB- receptor antagonist candesartan blocks brain AT -LRB- 1 -RRB- receptors .
11881123	0	candesartan	15,26	angiotensin_II	52,66	candesartan	angiotensin II	MESH:C081643	183	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|responses responses|nmod|END_ENTITY	The effects of candesartan on vascular responses to angiotensin_II and norepinephrine in normal volunteers .
12070762	0	candesartan	21,32	angiotensin_II	63,77	candesartan	angiotensin II	MESH:C081643	24179(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Peripherally applied candesartan inhibits central responses to angiotensin_II in conscious rats .
14661009	0	candesartan	52,63	angiotensin_II	20,34	candesartan	angiotensin II	MESH:C081643	183	Chemical	Gene	receptor|dobj|START_ENTITY receptor|nsubj|Effects Effects|nmod|END_ENTITY	Effects of low-dose angiotensin_II receptor blocker candesartan on cardiovascular_events in patients with coronary_artery_disease .
19927151	0	candesartan	39,50	angiotensin_II	76,90	candesartan	angiotensin II	MESH:C081643	183	Chemical	Gene	effects|nmod|START_ENTITY Comparison|nmod|effects END_ENTITY|nsubj|Comparison	Comparison of the long-term effects of candesartan and olmesartan on plasma angiotensin_II and left ventricular mass index in patients with hypertension .
19942928	0	candesartan	9,20	angiotensin_II	35,49	candesartan	angiotensin II	MESH:C081643	24179(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	Systemic candesartan reduces brain angiotensin_II via downregulation of brain renin-angiotensin system .
9892147	0	candesartan	17,28	angiotensin_II	58,72	candesartan	angiotensin II	MESH:C081643	24179(Tax:10116)	Chemical	Gene	influence|nmod|START_ENTITY influence|nmod|responses responses|nmod|END_ENTITY	The influence of candesartan and PD123319 on responses to angiotensin_II in the hindquarters vascular bed of the rat .
9892148	0	candesartan	11,22	angiotensin_II	52,66	candesartan	angiotensin II	MESH:C081643	11606(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|responses responses|nmod|END_ENTITY	Effects of candesartan and PD123319 on responses to angiotensin_II in the anesthetized mouse .
9892149	0	candesartan	27,38	angiotensin_II	55,69	candesartan	angiotensin II	MESH:C081643	183	Chemical	Gene	effects|nmod|START_ENTITY Analysis|nmod|effects Analysis|nmod|responses responses|nmod|END_ENTITY	Analysis of the effects of candesartan on responses to angiotensin_II in the hindquarters vascular bed of the cat .
11602819	0	candesartan	54,65	angiotensin_II_type_1_receptor	11,41	candesartan	angiotensin II type 1 receptor	MESH:C081643	403836(Tax:9615)	Chemical	Gene	Effects|appos|START_ENTITY Effects|nmod|antagonist antagonist|amod|END_ENTITY	Effects of angiotensin_II_type_1_receptor antagonist -LRB- candesartan -RRB- in preventing fatal ventricular_arrhythmias in dogs during acute_myocardial_ischemia and reperfusion .
14694243	0	candesartan	48,59	angiotensin_II_type_1_receptor	74,104	candesartan	angiotensin II type 1 receptor	MESH:C081643	81638(Tax:10116)	Chemical	Gene	cilexetil|compound|START_ENTITY cilexetil|appos|antagonist antagonist|amod|END_ENTITY	Reduction of bleomycin induced lung_fibrosis by candesartan cilexetil , an angiotensin_II_type_1_receptor antagonist .
24519206	0	candesartan	10,21	intercellular_adhesion_molecule-1	60,93	candesartan	intercellular adhesion molecule-1	MESH:C081643	100009455(Tax:9986)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	Effect of candesartan on the expression of sclera-choroidal intercellular_adhesion_molecule-1 in hypercholesterolemic models .
9892158	0	candesartan	11,22	renin	30,35	candesartan	renin	MESH:C081643	24715(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|system system|compound|END_ENTITY	Effects of candesartan on the renin system in conscious rats .
12492610	0	candesartan	10,21	type_1_angiotensin_II_receptor	25,55	candesartan	type 1 angiotensin II receptor	MESH:C081643	185	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|antagonist antagonist|amod|END_ENTITY	Effect of candesartan , a type_1_angiotensin_II_receptor antagonist , on bronchial hyper-responsiveness to methacholine in patients with bronchial_asthma .
17709654	0	candesartan	78,89	xanthine_oxidoreductase	8,31	candesartan	xanthine oxidoreductase	MESH:C081643	497811(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of xanthine_oxidoreductase in the reversal of diastolic_heart_failure by candesartan in the salt-sensitive hypertensive rat .
10965089	0	candesartan_cilexetil	67,88	angiotensin_II	40,54	candesartan cilexetil	angiotensin II	MESH:C077793	183	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|END_ENTITY	Hemodynamic and hormonal effects of the angiotensin_II antagonist , candesartan_cilexetil , in patients with congestive_heart_failure .
12011652	0	candesartan_cilexetil	26,47	angiotensin_II	72,86	candesartan cilexetil	angiotensin II	MESH:C077793	24179(Tax:10116)	Chemical	Gene	applied|dobj|START_ENTITY applied|nmod|END_ENTITY	Effects of orally applied candesartan_cilexetil on central responses to angiotensin_II in conscious rats .
9551878	0	candesartan_cilexetil	48,69	angiotensin_II	88,102	candesartan cilexetil	angiotensin II	MESH:C077793	183	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	The antihypertensive effect and tolerability of candesartan_cilexetil , a new generation angiotensin_II antagonist , in comparison with losartan .
26960737	0	candesartan_cilexetil	11,32	receptor_for_advanced_glycation_end_products	59,103	candesartan cilexetil	receptor for advanced glycation end products	MESH:C077793	81722(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effects of candesartan_cilexetil and amlodipine_orotate on receptor_for_advanced_glycation_end_products expression in the aortic wall of Otsuka Long-Evans Tokushima Fatty -LRB- OETFF -RRB- type 2 diabetic rats .
7925877	0	candoxatril	54,65	neutral_endopeptidase	22,43	candoxatril	neutral endopeptidase	MESH:C062766	4311	Chemical	Gene	effect|amod|START_ENTITY effect|nmod|END_ENTITY	No effect of the oral neutral_endopeptidase inhibitor candoxatril , on bronchomotor tone and histamine reactivity in asthma .
9088591	0	candoxatril	56,67	neutral_endopeptidase	18,39	candoxatril	neutral endopeptidase	MESH:C062766	4311	Chemical	Gene	drug|appos|START_ENTITY drug|amod|END_ENTITY	The effect of the neutral_endopeptidase inhibitor drug , candoxatril , on circulating levels of two of the most potent vasoactive peptides .
9821842	0	candoxatril	103,114	neutral_endopeptidase	21,42	candoxatril	neutral endopeptidase	MESH:C062766	24590(Tax:10116)	Chemical	Gene	administration|nmod|START_ENTITY END_ENTITY|nmod|administration	Inhibition of kidney neutral_endopeptidase after administration of the neutral_endopeptidase inhibitor candoxatril : quantitation by autoradiography .
21830205	2	canertinib	441,451	ErbB	425,429	canertinib	ErbB	MESH:C420268	1956	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	In this study we developed a quantitative , multivariate model to predict the extent of ovarian_cancer cell death following treatment with an ErbB inhibitor -LRB- canertinib , CI-1033 -RRB- .
8872468	0	canine	7,13	BRCA1	25,30	canine	BRCA1	null	12189(Tax:10090)	Chemical	Gene	genes|amod|START_ENTITY genes|compound|END_ENTITY	Human , canine and murine BRCA1 genes : sequence comparison among species .
16954046	1	canine	164,170	EIF2AK2	198,205	canine	EIF2AK2	null	100147679(Tax:9796)	Chemical	Gene	genes|amod|START_ENTITY genes|compound|END_ENTITY	The structures of the canine , rabbit , bovine and equine EIF2AK2 genes were determined .
8359553	0	canine	56,62	gastrin	70,77	canine	gastrin	null	100685087	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Effect of short-term administration of dexamethasone on canine antral gastrin gene expression .
16397386	0	canine	21,27	mucosal_addressin_cell_adhesion_molecule-1	28,70	canine	mucosal addressin cell adhesion molecule-1	null	54266(Tax:10116)	Chemical	Gene	cDNA|amod|START_ENTITY cDNA|amod|END_ENTITY	Molecular cloning of canine mucosal_addressin_cell_adhesion_molecule-1 cDNA and its expression in normal tissues .
6092626	0	canine	73,79	renin	86,91	canine	renin	null	403838(Tax:9615)	Chemical	Gene	release|amod|START_ENTITY release|compound|END_ENTITY	Mechanism of effect of dibutyryl_cyclic_adenosine_3 ' ,5 ' - monophosphate on canine renal renin release .
857313	0	canine	27,33	somatostatin	11,23	canine	somatostatin	null	403993(Tax:9615)	Chemical	Gene	secretion|amod|START_ENTITY END_ENTITY|nmod|secretion	-LSB- Effect of somatostatin on canine exocrine pancreas secretion stimulated by pancreozymin , secretin or test meal -RSB- .
23926240	0	cannabidiol	61,72	5-HT1A	12,18	cannabidiol	5-HT1A	MESH:D002185	15550(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY receptors|nmod|effects receptors|nummod|END_ENTITY	The role of 5-HT1A receptors in the anti-aversive effects of cannabidiol on panic_attack-like_behaviors evoked in the presence of the wild snake Epicrates cenchria crassus -LRB- Reptilia , Boidae -RRB- .
18446323	0	cannabidiol	65,76	5HT1A	15,20	cannabidiol	5HT1A	MESH:D002185	24473(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY receptors|nmod|effects receptors|nummod|END_ENTITY	Involvement of 5HT1A receptors in the anxiolytic-like effects of cannabidiol injected into the dorsolateral periaqueductal gray of rats .
18550765	0	cannabidiol	22,33	CGRP	47,51	cannabidiol	CGRP	MESH:D002185	24241(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY release|compound|END_ENTITY	TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons .
15313881	0	cannabidiol	98,109	TRPV1	10,15	cannabidiol	TRPV1	MESH:D002185	83810(Tax:10116)	Chemical	Gene	cannabinoid|xcomp|START_ENTITY nonpsychoactive|acl|cannabinoid effect|nmod|nonpsychoactive mediates|dobj|effect mediates|nsubj|receptor receptor|compound|END_ENTITY	Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid , cannabidiol , in a rat model of acute inflammation .
21483776	0	cannabidiol	137,148	TRPV1	118,123	cannabidiol	TRPV1	MESH:D002185	193034(Tax:10090)	Chemical	Gene	receptors|nmod|START_ENTITY receptors|nummod|END_ENTITY	Role of myeloid-derived suppressor cells in amelioration of experimental autoimmune hepatitis following activation of TRPV1 receptors by cannabidiol .
2550010	0	cannabidiol	10,21	cytochrome_P-450	25,41	cannabidiol	cytochrome P-450	MESH:D002185	13079(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|isozymes isozymes|amod|END_ENTITY	Effect of cannabidiol on cytochrome_P-450 isozymes .
2779523	0	cannabidiol	79,90	cytochrome_P-450	51,67	cannabidiol	cytochrome P-450	MESH:D002185	13079(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Purification Purification|nmod|END_ENTITY	Purification and characterization of a mouse liver cytochrome_P-450 induced by cannabidiol .
3202905	0	cannabidiol	88,99	cytochrome_P-450	142,158	cannabidiol	cytochrome P-450	MESH:D002185	13079(Tax:10090)	Chemical	Gene	metabolism|nmod|START_ENTITY carbon_monoxide|nmod|metabolism carbon_monoxide|advcl|END_ENTITY	Formation of similar species to carbon_monoxide during hepatic microsomal metabolism of cannabidiol on the basis of spectral interaction with cytochrome_P-450 .
3675599	0	cannabidiol	80,91	cytochrome_P-450	31,47	cannabidiol	cytochrome P-450	MESH:D002185	13079(Tax:10090)	Chemical	Gene	inactivation|nmod|START_ENTITY inactivation|nmod|END_ENTITY	Self-catalyzed inactivation of cytochrome_P-450 during microsomal metabolism of cannabidiol .
24667653	0	cannabidiol	127,138	cytochrome_P450_1A1	104,123	cannabidiol	cytochrome P450 1A1	MESH:D002185	1543	Chemical	Gene	required|nmod|START_ENTITY required|nmod|inhibition inhibition|nmod|END_ENTITY	Characterization of the structural determinants required for potent mechanism-based inhibition of human cytochrome_P450_1A1 by cannabidiol .
16754784	0	cannabidiol	71,82	p22phox	104,111	cannabidiol	p22phox	MESH:D002185	1535	Chemical	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Cannabidiol-induced apoptosis in human leukemia cells : A novel role of cannabidiol in the regulation of p22phox and Nox4 expression .
25242400	0	cannabidiolic_acid	47,65	cyclooxygenase-2	19,35	cannabidiolic acid	cyclooxygenase-2	MESH:C006884	5743	Chemical	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|nmod|END_ENTITY	Down-regulation of cyclooxygenase-2 -LRB- COX-2 -RRB- by cannabidiolic_acid in human breast_cancer cells .
8819477	0	cannabinoid	119,130	CB2	95,98	cannabinoid	CB2	CHEBI:67194	1269	Chemical	Gene	ligands|amod|START_ENTITY identification|nmod|ligands Evaluation|dep|identification Evaluation|nmod|binding binding|nmod|line line|acl|expressing expressing|dobj|receptor receptor|appos|END_ENTITY	Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor -LRB- CB2 -RRB- : identification of cannabinoid receptor subtype selective ligands .
17906686	0	cannabinoids	69,81	ABCG2	26,31	cannabinoids	ABCG2	MESH:D002186	9429	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|END_ENTITY	The multidrug transporter ABCG2 -LRB- BCRP -RRB- is inhibited by plant-derived cannabinoids .
19193902	0	cannabinoids	47,59	CB1	0,3	cannabinoids	CB1	MESH:D002186	25248(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY mediate|dobj|effects mediate|nsubj|receptors receptors|compound|END_ENTITY	CB1 receptors mediate the analgesic effects of cannabinoids on colorectal_distension-induced visceral_pain in rodents .
12069907	0	cannabinoids	14,26	CGRP	80,84	cannabinoids	CGRP	MESH:D002186	24241(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of cannabinoids on capsaicin-evoked calcitonin_gene-related_peptide -LRB- CGRP -RRB- release from the isolated paw skin of diabetic and non-diabetic rats .
8535411	0	cannabinoids	42,54	CYP2C	15,20	cannabinoids	CYP2C	MESH:D002186	1559	Chemical	Gene	metabolism|nmod|START_ENTITY Involvement|nmod|metabolism Involvement|nmod|END_ENTITY	Involvement of CYP2C in the metabolism of cannabinoids by human hepatic microsomes from an old woman .
11468287	0	cannabinoids	49,61	FAK	38,41	cannabinoids	FAK	MESH:D002186	14083(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|regulation regulation|nmod|END_ENTITY	Dual role of Fyn in the regulation of FAK +6,7 by cannabinoids in hippocampus .
11468287	0	cannabinoids	49,61	Fyn	13,16	cannabinoids	Fyn	MESH:D002186	14360(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Dual role of Fyn in the regulation of FAK +6,7 by cannabinoids in hippocampus .
16458258	0	cannabinoids	15,27	P-glycoprotein	31,45	cannabinoids	P-glycoprotein	MESH:D002186	5243	Chemical	Gene	START_ENTITY|nmod|transport transport|amod|END_ENTITY	The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells .
23983126	0	cantharidin	21,32	heat_shock_protein_70	81,102	cantharidin	heat shock protein 70	MESH:D002193	3308	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|inhibition inhibition|nmod|END_ENTITY	The natural compound cantharidin induces cancer cell death through inhibition of heat_shock_protein_70 -LRB- HSP70 -RRB- and Bcl-2-associated_athanogene_domain_3 -LRB- BAG3 -RRB- expression by blocking heat_shock_factor_1 -LRB- HSF1 -RRB- binding to promoters .
1442111	0	cantharidin	11,22	interleukin-2	26,39	cantharidin	interleukin-2	MESH:D002193	16183(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|production production|compound|END_ENTITY	Effects of cantharidin on interleukin-2 and interleukin-1 production in mice in vivo .
24255681	0	cantharidinate	71,85	S100A3	8,14	cantharidinate	S100A3	null	6274	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of S100A3 in human colorectal_cancer and the anticancer effect of cantharidinate .
19070128	0	canthaxanthin	16,29	HS-1	67,71	canthaxanthin	HS-1	MESH:D016644	1917	Chemical	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Optimization of canthaxanthin production by Dietzia natronolimnaea HS-1 using response surface methodology .
24820348	0	capecitabine	19,31	CPT-11	46,52	capecitabine	CPT-11	MESH:C110904	963084(Tax:115711)	Chemical	Gene	START_ENTITY|acl|combined combined|nmod|END_ENTITY	A phase I study of capecitabine combined with CPT-11 in metastatic_breast_cancer pretreated with anthracyclines and taxanes .
21684812	0	capecitabine	111,123	HER2	151,155	capecitabine	HER2	MESH:C110904	2064	Chemical	Gene	START_ENTITY|nmod|therapy therapy|nmod|END_ENTITY	Concurrent bevacizumab with a sequential regimen of doxorubicin and cyclophosphamide followed by docetaxel and capecitabine as neoadjuvant therapy for HER2 - locally_advanced_breast_cancer : a phase II trial of the NSABP Foundation Research Group .
15917420	0	capecitabine	74,86	Thymidine_phosphorylase	0,23	capecitabine	Thymidine phosphorylase	MESH:C110904	1890	Chemical	Gene	expression|acl|START_ENTITY expression|amod|END_ENTITY	Thymidine_phosphorylase expression in tumour cells and tumour response to capecitabine plus docetaxel chemotherapy in non-small_cell_lung_cancer .
17851858	0	capecitabine	26,38	VEGF	86,90	capecitabine	VEGF	MESH:C110904	7422	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|levels levels|compound|END_ENTITY	Daily low-dose/continuous capecitabine combined with neo-adjuvant irradiation reduces VEGF and PDGF-BB levels in rectal_carcinoma patients .
14657601	0	capecitabine	63,75	cytidine_deaminase	21,39	capecitabine	cytidine deaminase	MESH:C110904	978	Chemical	Gene	confers|advcl|START_ENTITY confers|nsubj|expression expression|nmod|END_ENTITY	Forced expression of cytidine_deaminase confers sensitivity to capecitabine .
16552574	0	capecitabine	41,53	thymidine_phosphorylase	72,95	capecitabine	thymidine phosphorylase	MESH:C110904	1890	Chemical	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Radiation recall phenomenon secondary to capecitabine : possible role of thymidine_phosphorylase .
15805738	0	caprine	17,24	PrP	25,28	caprine	PrP	CHEBI:44556	102169975	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Polymorphisms of caprine PrP gene detected in Japan .
11217909	0	capsaicin	50,59	ACE	4,7	capsaicin	ACE	MESH:D002211	1636	Chemical	Gene	polymorphism|nmod|START_ENTITY polymorphism|compound|END_ENTITY	The ACE gene polymorphism and cough threshold for capsaicin after cilazapril usage .
10543438	0	capsaicin	82,91	CGRP	42,46	capsaicin	CGRP	MESH:D002211	796	Chemical	Gene	produced|nmod|START_ENTITY responses|acl|produced END_ENTITY|nmod|responses	Involvement of endogenous tachykinins and CGRP in the motor responses produced by capsaicin in the guinea-pig common bile duct .
12855330	0	capsaicin	165,174	CGRP	45,49	capsaicin	CGRP	MESH:D002211	24241(Tax:10116)	Chemical	Gene	injection|nmod|START_ENTITY rats|nmod|injection role|nmod|rats role|appos|END_ENTITY	The role of calcitonin_gene-related_peptide -LRB- CGRP -RRB- in the generation and maintenance of mechanical allodynia and hyperalgesia in rats after intradermal injection of capsaicin .
12855330	6	capsaicin	952,961	CGRP	932,936	capsaicin	CGRP	MESH:D002211	24241(Tax:10116)	Chemical	Gene	injection|compound|START_ENTITY prior|nmod|injection END_ENTITY|advmod|prior	On the other hand , when rats were treated with CGRP -LRB- 8-37 -RRB- prior to capsaicin injection , the PWRs to von Frey applications were significantly reduced as compared to control animals .
14508237	0	capsaicin	8,17	CGRP	106,110	capsaicin	CGRP	MESH:D002211	24241(Tax:10116)	Chemical	Gene	relaxation|compound|START_ENTITY relaxation|dep|involvement involvement|nmod|END_ENTITY	A novel capsaicin derivative VOA induced relaxation in rat mesenteric and aortic arteries : involvement of CGRP , NO , cGMP , and endothelium-dependent activities .
16236814	5	capsaicin	960,969	CGRP	1018,1022	capsaicin	CGRP	MESH:D002211	24241(Tax:10116)	Chemical	Gene	treated|nmod|START_ENTITY treated|ccomp|-LSB- -LSB-|dobj|depleter depleter|nmod|calcitonin_gene-related_peptide calcitonin_gene-related_peptide|appos|END_ENTITY	In preparations treated with capsaicin -LSB- a depleter of calcitonin_gene-related_peptide -LRB- CGRP -RRB- - containing nerves -RSB- , L-NAME did not augment vasoconstrictor responses to PNS or NE injection .
1724624	0	capsaicin	39,48	CGRP	23,27	capsaicin	CGRP	MESH:D002211	796	Chemical	Gene	release|nmod|START_ENTITY END_ENTITY|dobj|release	Ruthenium-red inhibits CGRP release by capsaicin and resiniferatoxin but not by ouabain , bradykinin or nicotine in guinea-pig heart : correlation with effects on cardiac contractility .
21741970	0	capsaicin	20,29	CGRP	82,86	capsaicin	CGRP	MESH:D002211	12310(Tax:10090)	Chemical	Gene	responses|amod|START_ENTITY Characterization|nmod|responses Characterization|dep|evidence evidence|nmod|uptake uptake|compound|END_ENTITY	Characterization of capsaicin induced responses in mice vas deferens : evidence of CGRP uptake .
2438668	0	capsaicin	153,162	CGRP	33,37	capsaicin	CGRP	MESH:D002211	796	Chemical	Gene	distribution|nmod|START_ENTITY peptide|dep|distribution peptide|appos|END_ENTITY	Calcitonin gene-related peptide -LRB- CGRP -RRB- in capsaicin-sensitive substance_P-immunoreactive sensory neurons in animals and man : distribution and release by capsaicin .
25366550	0	capsaicin	8,17	CGRP	58,62	capsaicin	CGRP	MESH:D002211	796	Chemical	Gene	model|compound|START_ENTITY END_ENTITY|nsubj|model	A human capsaicin model to quantitatively assess salivary CGRP secretion .
3490562	0	capsaicin	55,64	CGRP	46,50	capsaicin	CGRP	MESH:D002211	24241(Tax:10116)	Chemical	Gene	Depletion|nmod|START_ENTITY Depletion|appos|END_ENTITY	Depletion of calcitonin gene-related peptide -LRB- CGRP -RRB- by capsaicin in cerebral arteries .
3490633	0	capsaicin	109,118	CGRP	41,45	capsaicin	CGRP	MESH:D002211	24241(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY effect|nmod|treatment Occurrence|dep|effect Occurrence|nmod|immunoreactivity immunoreactivity|compound|END_ENTITY	Occurrence , distribution and ontogeny of CGRP immunoreactivity in the rat lower respiratory tract : effect of capsaicin treatment and surgical denervations .
7690431	0	capsaicin	126,135	CGRP	15,19	capsaicin	CGRP	MESH:D002211	24241(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY lesions|nmod|treatment lesions|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of CGRP , substance P and blood circulation in aggravating mechanism of absolute ethanol-induced antral lesions by capsaicin treatment in rats .
7862250	0	capsaicin	39,48	CGRP	77,81	capsaicin	CGRP	MESH:D002211	24241(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY mechanisms|nmod|effects mechanisms|nmod|release release|compound|END_ENTITY	Multiple mechanisms for the effects of capsaicin , bradykinin and nicotine on CGRP release from tracheal afferent nerves : role of prostaglandins , sympathetic nerves and mast cells .
8483803	0	capsaicin	24,33	CGRP	74,78	capsaicin	CGRP	MESH:D002211	24241(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of neonatal capsaicin on plasma levels and tissue contents of CGRP .
9657352	0	capsaicin	26,35	CGRP	8,12	capsaicin	CGRP	MESH:D002211	24241(Tax:10116)	Chemical	Gene	depletion|nmod|START_ENTITY depletion|compound|END_ENTITY	Sensory CGRP depletion by capsaicin exacerbates hypoxia-induced pulmonary_hypertension in rats .
7093671	0	capsaicin	84,93	Cholecystokinin	0,15	capsaicin	Cholecystokinin	MESH:D002211	25298(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY effect|nmod|treatment distribution|nmod|effect END_ENTITY|dep|distribution	Cholecystokinin in the rat spinal cord : distribution and lack of effect of neonatal capsaicin treatment and rhizotomy .
25255125	0	capsaicin	24,33	FASN	37,41	capsaicin	FASN	MESH:D002211	2194	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	The selective target of capsaicin on FASN expression and de novo fatty_acid synthesis mediated through ROS generation triggers apoptosis in HepG2 cells .
21474332	0	capsaicin	14,23	IL-6	32,36	capsaicin	IL-6	MESH:D002211	3569	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|secretion secretion|compound|END_ENTITY	The vanilloid capsaicin induces IL-6 secretion in prostate PC-3 cancer cells .
9394044	0	capsaicin	129,138	Pituitary_adenylate_cyclase_activating_polypeptide	0,50	capsaicin	Pituitary adenylate cyclase activating polypeptide	MESH:D002211	24166(Tax:10116)	Chemical	Gene	distribution|nmod|START_ENTITY END_ENTITY|dep|distribution	Pituitary_adenylate_cyclase_activating_polypeptide -LRB- PACAP -RRB- in the gastrointestinal tract of the rat : distribution and effects of capsaicin or denervation .
502756	0	capsaicin	47,56	Substance_P	0,11	capsaicin	Substance P	MESH:D002211	6863	Chemical	Gene	slices|nmod|START_ENTITY slices|nsubj|release release|amod|END_ENTITY	Substance_P release from spinal cord slices by capsaicin .
6163995	0	capsaicin	72,81	Substance_P	0,11	capsaicin	Substance P	MESH:D002211	6863	Chemical	Gene	administration|nmod|START_ENTITY neurons|nmod|administration neurons|nsubj|immunoreactive immunoreactive|amod|END_ENTITY	Substance_P immunoreactive neurons following neonatal administration of capsaicin .
14523239	0	capsaicin	70,79	TRPV1	131,136	capsaicin	TRPV1	MESH:D002211	7442	Chemical	Gene	potential|amod|START_ENTITY potential|appos|END_ENTITY	Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 -LRB- TRPV1 -RRB- .
14699077	0	capsaicin	46,55	TRPV1	26,31	capsaicin	TRPV1	MESH:D002211	7442	Chemical	Gene	modulates|nmod|START_ENTITY modulates|dobj|activation activation|compound|END_ENTITY	Ca2 + / calmodulin modulates TRPV1 activation by capsaicin .
15128843	4	capsaicin	686,695	TRPV1	646,651	capsaicin	TRPV1	MESH:D002211	193034(Tax:10090)	Chemical	Gene	currents|amod|START_ENTITY increased|dobj|currents increased|advcl|expressing expressing|dobj|END_ENTITY	In human embryonic kidney 293 cells expressing TRPV1 and PAR2 , PAR2 agonists increased capsaicin - or proton-evoked TRPV1 currents through a PKC-dependent pathway .
15316415	0	capsaicin	10,19	TRPV1	29,34	capsaicin	TRPV1	MESH:D002211	7442	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|nsubj|receptor	Increased capsaicin receptor TRPV1 nerve fibres in the inflamed human oesophagus .
15464045	0	capsaicin	27,36	TRPV1	48,53	capsaicin	TRPV1	MESH:D002211	7442	Chemical	Gene	_|appos|START_ENTITY role|nmod|_ _|nsubj|role _|dobj|receptor receptor|appos|END_ENTITY	The role of the vanilloid _ -LRB- capsaicin -RRB- _ receptor -LRB- TRPV1 -RRB- in physiology and pathology .
15492487	0	capsaicin	119,128	TRPV1	86,91	capsaicin	TRPV1	MESH:D002211	83810(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|mRNA mRNA|compound|END_ENTITY	Differential regulation of 3-beta-hydroxysteroid dehydrogenase and vanilloid receptor TRPV1 mRNA in sensory neurons by capsaicin and NGF .
15967267	0	capsaicin	65,74	TRPV1	58,63	capsaicin	TRPV1	MESH:D002211	7442	Chemical	Gene	receptor|compound|START_ENTITY receptor|nummod|END_ENTITY	The distribution of sensory fibers immunoreactive for the TRPV1 -LRB- capsaicin -RRB- _ receptor in the human prostate .
16100528	2	capsaicin	406,415	TRPV1	435,440	capsaicin	TRPV1	MESH:D002211	7442	Chemical	Gene	gating|appos|START_ENTITY gating|nmod|receptor receptor|compound|END_ENTITY	Previously , selective mutagenesis experiments identified an intracellular residue -LRB- S512Y -RRB- critical to discriminating between pH and vanilloid -LRB- capsaicin -RRB- gating of the rat TRPV1 receptor .
16191202	0	capsaicin	50,59	TRPV1	21,26	capsaicin	TRPV1	MESH:D002211	83810(Tax:10116)	Chemical	Gene	responses|compound|START_ENTITY kinetics|nmod|responses alters|dobj|kinetics alters|nsubj|Acidification Acidification|nmod|END_ENTITY	Acidification of rat TRPV1 alters the kinetics of capsaicin responses .
16216696	0	capsaicin	96,105	TRPV1	0,5	capsaicin	TRPV1	MESH:D002211	193034(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY analgesia|acl|induced vanilloid|nmod|analgesia vanilloid|nsubj|desensitisation desensitisation|compound|END_ENTITY	TRPV1 desensitisation and endogenous vanilloid involvement in the enhanced analgesia induced by capsaicin in inflamed tissues .
16269136	10	capsaicin	1528,1537	TRPV1	1610,1615	capsaicin	TRPV1	MESH:D002211	83810(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|acl:relcl|express express|dobj|receptor receptor|compound|END_ENTITY	These effects of capsaicin on different VACCs in small DRG neurones , which most likely express the TRPV1 receptor , may represent another mechanism of action of the pungent substance capsaicin in addition to opening of TRPV1 .
16269136	10	capsaicin	1693,1702	TRPV1	1610,1615	capsaicin	TRPV1	MESH:D002211	83810(Tax:10116)	Chemical	Gene	action|nmod|START_ENTITY mechanism|nmod|action represent|dobj|mechanism represent|nsubj|effects effects|acl:relcl|express express|dobj|receptor receptor|compound|END_ENTITY	These effects of capsaicin on different VACCs in small DRG neurones , which most likely express the TRPV1 receptor , may represent another mechanism of action of the pungent substance capsaicin in addition to opening of TRPV1 .
17018028	0	capsaicin	67,76	TRPV1	43,48	capsaicin	TRPV1	MESH:D002211	7442	Chemical	Gene	heat|compound|START_ENTITY pH|compound|heat regulates|nmod|pH regulates|dobj|responsiveness responsiveness|nummod|END_ENTITY	TRPV1b overexpression negatively regulates TRPV1 responsiveness to capsaicin , heat and low pH in HEK293 cells .
17035013	0	capsaicin	96,105	TRPV1	51,56	capsaicin	TRPV1	MESH:D002211	7442	Chemical	Gene	showed|nmod|START_ENTITY showed|nsubj|Halogenation Halogenation|nmod|agonists agonists|compound|END_ENTITY	Halogenation of 4-hydroxy-3-methoxybenzyl thiourea TRPV1 agonists showed enhanced antagonism to capsaicin .
17110039	0	capsaicin	36,45	TRPV1	121,126	capsaicin	TRPV1	MESH:D002211	7442	Chemical	Gene	total|nmod|START_ENTITY Induction|acl|total decreased|nsubj|Induction decreased|dobj|expression expression|nmod|END_ENTITY	Induction of total insensitivity to capsaicin and hypersensitivity to garlic extract in human by decreased expression of TRPV1 .
17521436	0	capsaicin	31,40	TRPV1	50,55	capsaicin	TRPV1	MESH:D002211	7442	Chemical	Gene	receptor|compound|START_ENTITY expression|nmod|receptor END_ENTITY|nsubj|expression	Differential expression of the capsaicin receptor TRPV1 and related novel receptors TRPV3 , TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic_neuropathy .
17584831	3	capsaicin	518,527	TRPV1	531,536	capsaicin	TRPA1	MESH:D002211	8989	Chemical	Gene	START_ENTITY|dep|agonist agonist|compound|END_ENTITY	Here we show that TRPA1 is desensitized by homologous -LRB- mustard oil ; a TRPA1 agonist -RRB- and heterologous -LRB- capsaicin ; a TRPV1 agonist -RRB- agonists via Ca2 + - independent and Ca2 + - dependent pathways , respectively , in sensory neurons .
17632091	0	capsaicin	11,20	TRPV1	33,38	capsaicin	TRPV1	MESH:D002211	193034(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of capsaicin on VGSCs in TRPV1 - / - mice .
17651868	0	capsaicin	47,56	TRPV1	73,78	capsaicin	TRPV1	MESH:D002211	193034(Tax:10090)	Chemical	Gene	transmission|nmod|START_ENTITY Control|nmod|transmission unaltered|nsubj|Control unaltered|nmod|mice mice|nummod|END_ENTITY	Control of excitatory synaptic transmission by capsaicin is unaltered in TRPV1 vanilloid receptor knockout mice .
17950047	0	capsaicin	45,54	TRPV1	113,118	capsaicin	TRPV1	MESH:D002211	83810(Tax:10116)	Chemical	Gene	24h|compound|START_ENTITY response|nmod|24h Potentiation|nmod|response mediated|nsubjpass|Potentiation mediated|nmod|END_ENTITY	Potentiation of pulmonary reflex response to capsaicin 24h following whole-body acrolein exposure is mediated by TRPV1 .
17961222	0	capsaicin	137,146	TRPV1	9,14	capsaicin	TRPV1	MESH:D002211	83810(Tax:10116)	Chemical	Gene	injection|nmod|START_ENTITY induced|nmod|injection neurogenic_inflammation|acl|induced root|dobj|neurogenic_inflammation root|nsubj|Roles Roles|nmod|END_ENTITY	Roles of TRPV1 and neuropeptidergic receptors in dorsal root reflex-mediated neurogenic_inflammation induced by intradermal injection of capsaicin .
18240098	0	capsaicin	34,43	TRPV1	45,50	capsaicin	TRPV1	MESH:D002211	7442	Chemical	Gene	START_ENTITY|appos|agonist agonist|nummod|END_ENTITY	Adlea -LRB- ALGRX-4975 -RRB- , an injectable capsaicin -LRB- TRPV1 receptor agonist -RRB- formulation for longlasting pain relief .
18414789	0	capsaicin	42,51	TRPV1	61,66	capsaicin	TRPV1	MESH:D002211	7442	Chemical	Gene	localisation|compound|START_ENTITY localisation|nummod|END_ENTITY	Cytosine_arabinoside affects the heat and capsaicin receptor TRPV1 localisation and sensitivity in human sensory neurons .
18460982	0	capsaicin	36,45	TRPV1	21,26	capsaicin	TRPV1	MESH:D002211	83810(Tax:10116)	Chemical	Gene	agonists|dobj|START_ENTITY agonists|nsubj|effect effect|nmod|END_ENTITY	Preventive effect of TRPV1 agonists capsaicin and resiniferatoxin on ischemia/reperfusion-induced renal_injury in rats .
18481914	0	capsaicin	140,149	TRPV1	56,61	capsaicin	TRPV1	MESH:D002211	7442	Chemical	Gene	application|nmod|START_ENTITY induced|nmod|application analgesia|acl|induced involved|nmod|analgesia mechanism|acl|involved desensitization|dep|mechanism desensitization|nmod|END_ENTITY	Calcium-dependent desensitization of vanilloid receptor TRPV1 : a mechanism possibly involved in analgesia induced by topical application of capsaicin .
18519133	0	capsaicin	85,94	TRPV1	54,59	capsaicin	TRPV1	MESH:D002211	7442	Chemical	Gene	oscillations|nmod|START_ENTITY oscillations|nmod|activation activation|compound|END_ENTITY	Sustained increase of Ca +2 oscillations after chronic TRPV1 receptor activation with capsaicin in cultured spinal neurons .
18832423	0	capsaicin	47,56	TRPV1	22,27	capsaicin	TRPV1	MESH:D002211	83810(Tax:10116)	Chemical	Gene	expression|acl|START_ENTITY expression|nmod|END_ENTITY	Altered expression of TRPV1 and sensitivity to capsaicin in pulmonary myelinated afferents following chronic airway_inflammation in the rat .
18973552	0	capsaicin	84,93	TRPV1	75,80	capsaicin	TRPV1	MESH:D002211	83810(Tax:10116)	Chemical	Gene	basal|nmod|START_ENTITY basal|dobj|responses responses|nmod|END_ENTITY	Protein_kinase_C_epsilon contributes to basal and sensitizing responses of TRPV1 to capsaicin in rat dorsal root ganglion neurons .
19333172	0	capsaicin	10,19	TRPV1	29,34	capsaicin	TRPV1	MESH:D002211	7442	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|nsubj|receptor	Increased capsaicin receptor TRPV1 in the peritoneum of women with chronic_pelvic_pain .
19497956	0	capsaicin	48,57	TRPV1	16,21	capsaicin	TRPV1	MESH:D002211	193034(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|compound|END_ENTITY	Localization of TRPV1 and contractile effect of capsaicin in mouse large intestine : high abundance and sensitivity in rectum and distal colon .
19502594	0	capsaicin	71,80	TRPV1	61,66	capsaicin	TRPV1	MESH:D002211	7442	Chemical	Gene	Triggering|nmod|START_ENTITY Triggering|nmod|transient_receptor_potential_vanilloid_type_1 transient_receptor_potential_vanilloid_type_1|appos|END_ENTITY	Triggering of transient_receptor_potential_vanilloid_type_1 -LRB- TRPV1 -RRB- by capsaicin induces Fas/CD95-mediated apoptosis of urothelial_cancer cells in an ATM-dependent manner .
19800272	0	capsaicin	65,74	TRPV1	41,46	capsaicin	TRPV1	MESH:D002211	83810(Tax:10116)	Chemical	Gene	agonists|dobj|START_ENTITY agonists|nsubj|actions actions|nmod|receptor receptor|compound|END_ENTITY	Antinociceptive desensitizing actions of TRPV1 receptor agonists capsaicin , resiniferatoxin and N-oleoyldopamine as measured by determination of the noxious heat and cold thresholds in the rat .
20580681	0	capsaicin	25,34	TRPV1	11,16	capsaicin	TRPV1	MESH:D002211	100135466(Tax:10141)	Chemical	Gene	challenge|compound|START_ENTITY agonist|dobj|challenge agonist|nsubj|END_ENTITY	Intranasal TRPV1 agonist capsaicin challenge and its effect on c-fos expression in the guinea_pig brainstem .
20937561	0	capsaicin	103,112	TRPV1	58,63	capsaicin	TRPV1	MESH:D002211	100771135	Chemical	Gene	showed|nmod|START_ENTITY showed|nsubj|agonists agonists|compound|END_ENTITY	Halogenation of 4-hydroxy/amino -3 - methoxyphenyl_acetamide TRPV1 agonists showed enhanced antagonism to capsaicin .
21204495	0	capsaicin	114,123	TRPV1	22,27	capsaicin	TRPV1	MESH:D002211	83810(Tax:10116)	Chemical	Gene	characterized|nmod|START_ENTITY characterized|nsubjpass|Regulation Regulation|nmod|END_ENTITY	Complex Regulation of TRPV1 by Vanilloids A subset of sensory neurons is characterized by a unique sensitivity to capsaicin , the piquant ingredient in hot chili peppers -LSB- 1 -RSB- .
21215315	0	capsaicin	64,73	TRPV1	125,130	capsaicin	TRPV1	MESH:D002211	7442	Chemical	Gene	START_ENTITY|nmod|capability capability|nmod|receptor receptor|compound|END_ENTITY	N-palmitoyl-vanillamide -LRB- palvanil -RRB- is a non-pungent analogue of capsaicin with stronger desensitizing capability against the TRPV1 receptor and anti-hyperalgesic activity .
21430411	0	capsaicin	20,29	TRPV1	43,48	capsaicin	TRPV1	MESH:D002211	83810(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY treatment|nmod|NK NK|compound|END_ENTITY	Effects of systemic capsaicin treatment on TRPV1 and Tachykinin NK -LRB- 1 -RRB- _ receptor distribution and function in the nucleus of the solitary tract of the adult rat .
21536874	0	capsaicin	61,70	TRPV1	32,37	capsaicin	TRPV1	MESH:D002211	7442	Chemical	Gene	analog|compound|START_ENTITY targeting|nmod|analog targeting|nmod|END_ENTITY	Activity-dependent targeting of TRPV1 with a pore-permeating capsaicin analog .
22215506	0	capsaicin	68,77	TRPV1	59,64	capsaicin	TRPV1	MESH:D002211	83810(Tax:10116)	Chemical	Gene	Transient_receptor_potential_vanilloid_1|compound|START_ENTITY END_ENTITY|nmod|Transient_receptor_potential_vanilloid_1	Differential effects of acute hypoxia on the activation of TRPV1 by capsaicin and acidic pH. Transient_receptor_potential_vanilloid_1 -LRB- TRPV1 -RRB- is a Ca -LRB- 2 + -RRB- - permeable cation channel activated by a variety of physicochemical stimuli .
22412190	0	capsaicin	65,74	TRPV1	89,94	capsaicin	TRPV1	MESH:D002211	7442	Chemical	Gene	activation|compound|START_ENTITY activation|nmod|channels channels|nummod|END_ENTITY	Selective disruption of high sensitivity heat activation but not capsaicin activation of TRPV1 channels by pore turret mutations .
22570472	0	capsaicin	79,88	TRPV1	73,78	capsaicin	TRPV1	MESH:D002211	7442	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	N-glycosylation determines ionic permeability and desensitization of the TRPV1 capsaicin receptor .
23111447	0	capsaicin	90,99	TRPV1	0,5	capsaicin	TRPV1	MESH:D002211	193034(Tax:10090)	Chemical	Gene	administration|compound|START_ENTITY modulated|nmod|administration modulated|nsubjpass|properties properties|nummod|END_ENTITY	TRPV1 properties in thoracic dorsal root ganglia neurons are modulated by intraperitoneal capsaicin administration in the late phase of type-1 autoimmune diabetes .
23264449	0	capsaicin	63,72	TRPV1	30,35	capsaicin	TRPV1	MESH:D002211	193034(Tax:10090)	Chemical	Gene	activation|compound|START_ENTITY antagonists|nmod|activation antagonists|nummod|END_ENTITY	Novel methodology to identify TRPV1 antagonists independent of capsaicin activation .
23402980	0	capsaicin	77,86	TRPV1	16,21	capsaicin	TRPV1	MESH:D002211	83810(Tax:10116)	Chemical	Gene	permeation|nmod|START_ENTITY Contribution|nmod|permeation Contribution|nmod|proteins proteins|compound|END_ENTITY	Contribution of TRPV1 and multidrug resistance proteins in the permeation of capsaicin across different intestinal regions .
23796768	0	capsaicin	52,61	TRPV1	184,189	capsaicin	TRPV1	MESH:D002211	7442	Chemical	Gene	analogues|amod|START_ENTITY Design|nmod|analogues based|nsubj|Design reveal|advcl|based reveal|dobj|family family|nmod|antagonists antagonists|appos|END_ENTITY	Design and synthesis of conformationally restricted capsaicin analogues based in the 1 , _ 3 , _ 4-thiadiazole heterocycle reveal a novel family of transient_receptor_potential_vanilloid_1 -LRB- TRPV1 -RRB- antagonists .
24189713	0	capsaicin	60,69	TRPV1	92,97	capsaicin	TRPV1	MESH:D002211	7442	Chemical	Gene	stimulations|compound|START_ENTITY testing|nmod|stimulations role|dep|testing role|nmod|END_ENTITY	Sensitivity testing in irritable_bowel_syndrome with rectal capsaicin stimulations : role of TRPV1 upregulation and sensitization in visceral_hypersensitivity ?
24975423	0	capsaicin	54,63	TRPV1	39,44	capsaicin	TRPV1	MESH:D002211	83810(Tax:10116)	Chemical	Gene	Effects|acl|START_ENTITY Effects|nmod|treatment treatment|nmod|agonist agonist|compound|END_ENTITY	Effects of neonatal treatment with the TRPV1 agonist , capsaicin , on adult rat brain and behaviour .
25014183	5	capsaicin	1304,1313	TRPV1	1512,1517	capsaicin	TRPV1	MESH:D002211	7442	Chemical	Gene	showed|advcl|START_ENTITY desensitized|advcl|showed desensitized|nsubj|GW7647 GW7647|acl:relcl|activate activate|advmod|se se|dep|currents currents|nummod|END_ENTITY	When compared to capsaicin -LRB- CAP -RRB- , TRPV1 currents activated by PPARa agonists showed a higher degree of acute desensitization and tachyphylaxis ; moreover , GW7647 , when pre-incubated at a concentration -LRB- 1nM -RRB- unable to activate TRPV1 currents per se , desensitized CAP-induced TRPV1 currents .
25782545	0	capsaicin	39,48	TRPV1	14,19	capsaicin	TRPV1	MESH:D002211	193034(Tax:10090)	Chemical	Gene	channel|nmod|START_ENTITY channel|nummod|END_ENTITY	Activation of TRPV1 channel by dietary capsaicin improves visceral fat remodeling through connexin43-mediated Ca -LRB- 2 + -RRB- Influx .
25849380	0	capsaicin	39,48	TRPV1	14,19	capsaicin	TRPV1	MESH:D002211	193034(Tax:10090)	Chemical	Gene	channel|nmod|START_ENTITY channel|nummod|END_ENTITY	Activation of TRPV1 channel by dietary capsaicin improves visceral fat remodeling through connexin43-mediated Ca2 + Influx .
26053297	0	capsaicin	32,41	TRPV1	72,77	capsaicin	TRPV1	MESH:D002211	7442	Chemical	Gene	mechanism|dep|START_ENTITY mechanism|nmod|channel channel|compound|END_ENTITY	Structural mechanism underlying capsaicin binding and activation of the TRPV1 ion channel .
26526845	8	capsaicin	1216,1225	TRPV1	1172,1177	capsaicin	TRPV1	MESH:D002211	83810(Tax:10116)	Chemical	Gene	activation|nmod|START_ENTITY activation|nummod|END_ENTITY	At all developmental stages , TRPV1 activation with the selective agonist capsaicin increases glutamate release in the presence of tetrodotoxin , which blocks action potential-dependent and polysynaptic neurotransmission , indicating that functional TRPV1 fibers innervate SDCN neurons directly .
26645885	0	capsaicin	22,31	TRPV1	95,100	capsaicin	TRPV1	MESH:D002211	7442	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activities activities|nmod|END_ENTITY	Reciprocal effects of capsaicin and menthol on thermosensation through regulated activities of TRPV1 and TRPM8 .
26719417	0	capsaicin	78,87	TRPV1	14,19	capsaicin	TRPV1	MESH:D002211	7442	Chemical	Gene	modes|nmod|START_ENTITY Insights|nmod|modes Insights|dep|Understanding Understanding|dobj|activation activation|compound|END_ENTITY	Understanding TRPV1 activation by ligands : Insights from the binding modes of capsaicin and resiniferatoxin .
24890824	0	capsaicin	63,72	Transient_receptor_potential_vanilloid_1	0,40	capsaicin	Transient receptor potential vanilloid 1	MESH:D002211	193034(Tax:10090)	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Transient_receptor_potential_vanilloid_1 activation by dietary capsaicin promotes urinary sodium excretion by inhibiting epithelial sodium channel a subunit-mediated sodium reabsorption .
18582539	0	capsaicin	82,91	Tumor_necrosis_factor_alpha	0,27	capsaicin	Tumor necrosis factor alpha	MESH:D002211	24835(Tax:10116)	Chemical	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	Tumor_necrosis_factor_alpha enhances the sensitivity of rat trigeminal neurons to capsaicin .
10619474	0	capsaicin	88,97	VR1	70,73	capsaicin	VR1	MESH:D002211	83810(Tax:10116)	Chemical	Gene	receptors|nmod|START_ENTITY receptors|nsubj|accumulation accumulation|nmod|activation activation|nmod|_ _|appos|END_ENTITY	Mitochondrial calcium accumulation following activation of vanilloid _ -LRB- VR1 -RRB- receptors by capsaicin in dorsal root ganglion neurons .
11259480	0	capsaicin	127,136	VR1	20,23	capsaicin	VR1	MESH:D002211	56664	Chemical	Gene	sensitivity|compound|START_ENTITY transport|nmod|sensitivity transport|nmod|mRNA mRNA|compound|END_ENTITY	Axonal transport of VR1 capsaicin receptor mRNA in primary afferents and its participation in inflammation-induced increase in capsaicin sensitivity .
11259480	0	capsaicin	24,33	VR1	20,23	capsaicin	VR1	MESH:D002211	56664	Chemical	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	Axonal transport of VR1 capsaicin receptor mRNA in primary afferents and its participation in inflammation-induced increase in capsaicin sensitivity .
11448475	0	capsaicin	105,114	VR1	62,65	capsaicin	VR1	MESH:D002211	83810(Tax:10116)	Chemical	Gene	expressed|nmod|START_ENTITY expressed|nsubj|receptors receptors|compound|END_ENTITY	Temperature-dependent activation of recombinant rat vanilloid VR1 receptors expressed in HEK293 cells by capsaicin and anandamide .
11483711	0	capsaicin	80,89	VR1	73,76	capsaicin	VR1	MESH:D002211	7442	Chemical	Gene	gating|nmod|START_ENTITY gating|nmod|END_ENTITY	Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin , protons , heat and anandamide .
11514026	0	capsaicin	4,13	VR1	14,17	capsaicin	VR1	MESH:D002211	83810(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	The capsaicin VR1 receptor mediates substance P release in toxin A-induced enteritis in rats .
12098622	0	capsaicin	55,64	VR1	48,51	capsaicin	VR1	MESH:D002211	7442	Chemical	Gene	sensitizes|nmod|START_ENTITY sensitizes|dobj|END_ENTITY	Activation of protein kinase C sensitizes human VR1 to capsaicin and to moderate decreases in pH at physiological temperatures in Xenopus oocytes .
12835470	0	capsaicin	24,33	VR1	64,67	capsaicin	VR1	MESH:D002211	56664	Chemical	Gene	binding|compound|START_ENTITY binding|nmod|receptors receptors|nummod|END_ENTITY	Low pH potentiates both capsaicin binding and channel gating of VR1 receptors .
14581201	0	capsaicin	44,53	VR1	67,70	capsaicin	VR1	MESH:D002211	7442	Chemical	Gene	channels|compound|START_ENTITY activation|nmod|channels Thermodynamics|nmod|activation END_ENTITY|nsubj|Thermodynamics	Thermodynamics of heat activation of single capsaicin ion channels VR1 .
9708861	0	capsaicin	74,83	VR1	95,98	capsaicin	VR1	MESH:D002211	83810(Tax:10116)	Chemical	Gene	mRNA|appos|START_ENTITY mRNA|appos|END_ENTITY	Capsaicin sensitivity is associated with the expression of the vanilloid _ -LRB- capsaicin -RRB- _ receptor -LRB- VR1 -RRB- mRNA in adult rat sensory ganglia .
10401552	0	capsaicin	38,47	c-fos	56,61	capsaicin	c-fos	MESH:D002211	314322(Tax:10116)	Chemical	Gene	START_ENTITY|acl|induced induced|dobj|expression expression|amod|END_ENTITY	Non-NMDA glutamate receptors modulate capsaicin induced c-fos expression within trigeminal nucleus caudalis .
12566162	0	capsaicin	22,31	calcitonin	40,50	capsaicin	calcitonin	MESH:D002211	24241(Tax:10116)	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Flurbiprofen inhibits capsaicin induced calcitonin gene related peptide release from rat spinal cord via an endocannabinoid dependent mechanism .
1656776	0	capsaicin	86,95	calcitonin_gene-related_peptide	8,39	capsaicin	calcitonin gene-related peptide	MESH:D002211	24241(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of calcitonin_gene-related_peptide in gastric hyperemic response to intragastric capsaicin .
3497262	0	capsaicin	10,19	calcitonin_gene-related_peptide	74,105	capsaicin	calcitonin gene-related peptide	MESH:D002211	24241(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|involvement involvement|nmod|END_ENTITY	Effect of capsaicin on smooth muscles of rat vas deferens : involvement of calcitonin_gene-related_peptide ?
9698167	0	capsaicin	14,23	calcitonin_gene-related_peptide	46,77	capsaicin	calcitonin gene-related peptide	MESH:D002211	24241(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY release|amod|END_ENTITY	Alteration of capsaicin and endotoxin-induced calcitonin_gene-related_peptide release from mesenteric arterial bed and spinal cord slice in 18-month-old rats .
1371709	0	capsaicin	19,28	cholecystokinin	42,57	capsaicin	cholecystokinin	MESH:D002211	25298(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY treatment|nmod|END_ENTITY	Effect of neonatal capsaicin treatment on cholecystokinin - -LRB- CCK8 -RRB- satiety and axonal transport of CCK binding sites in the rat vagus nerve .
18554636	0	capsaicin	113,122	cyclooxygenase-2	52,68	capsaicin	cyclooxygenase-2	MESH:D002211	29527(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Intraprostatic botulinum toxin a injection inhibits cyclooxygenase-2 expression and suppresses prostatic_pain on capsaicin induced prostatitis model in rat .
24889371	3	capsaicin	735,744	death	697,702	capsaicin	TRPV1	MESH:D002211	7442	Chemical	Gene	mediated|nmod|START_ENTITY END_ENTITY|acl|mediated	We developed an MCF-7_breast_cancer cell line with inducible TRPV1 overexpression and assessed the role of TRPV1 levels on cell death mediated by the TRPV1 activator capsaicin and the potential for submaximal activation to promote proliferation .
18668366	0	capsaicin	15,24	gastrin	28,35	capsaicin	gastrin	MESH:D002211	2520	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|secretion secretion|compound|END_ENTITY	The effects of capsaicin on gastrin secretion in isolated human antral glands : before and after ingestion of red chilli .
23013364	0	capsaicin	11,20	ghrelin	31,38	capsaicin	ghrelin	MESH:D002211	58991(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of capsaicin on testis ghrelin expression in mice .
17569567	0	capsaicin	18,27	insulin-like_growth_factor-I	78,106	capsaicin	insulin-like growth factor-I	MESH:D002211	16000(Tax:10090)	Chemical	Gene	Administration|nmod|START_ENTITY promotes|nsubj|Administration promotes|advcl|increasing increasing|dobj|production production|amod|END_ENTITY	Administration of capsaicin and isoflavone promotes hair growth by increasing insulin-like_growth_factor-I production in mice and in humans with alopecia .
17693108	0	capsaicin	10,19	insulin-like_growth_factor-I	51,79	capsaicin	insulin-like growth factor-I	MESH:D002211	24482(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|rats rats|amod|END_ENTITY	Effect of capsaicin on plasma and tissue levels of insulin-like_growth_factor-I in spontaneously hypertensive rats .
19502719	0	capsaicin	11,20	insulin-like_growth_factor-I	74,102	capsaicin	insulin-like growth factor-I	MESH:D002211	3479	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of capsaicin and isoflavone on blood pressure and serum levels of insulin-like_growth_factor-I in normotensive and hypertensive volunteers with alopecia .
12433964	0	capsaicin	95,104	nerve_growth_factor	46,65	capsaicin	nerve growth factor	MESH:D002211	310738(Tax:10116)	Chemical	Gene	injection|nmod|START_ENTITY END_ENTITY|nmod|injection	Upregulation of proinflammatory cytokines and nerve_growth_factor by intraplantar injection of capsaicin in rats .
2452458	0	capsaicin	96,105	substance_P	72,83	capsaicin	substance P	MESH:D002211	6863	Chemical	Gene	effect|compound|START_ENTITY release|nmod|effect release|nsubj|Calcitonin_gene-related_peptide Calcitonin_gene-related_peptide|dep|coexistence coexistence|nmod|END_ENTITY	Calcitonin_gene-related_peptide and the lung : neuronal coexistence with substance_P , release by capsaicin and vasodilatory effect .
6182949	0	capsaicin	64,73	substance_P	14,25	capsaicin	substance P	MESH:D002211	21333(Tax:10090)	Chemical	Gene	disruption|nmod|START_ENTITY Regulation|dep|disruption Regulation|nmod|END_ENTITY	Regulation of substance_P by nerve_growth_factor : disruption by capsaicin .
6189034	0	capsaicin	24,33	substance_P	57,68	capsaicin	substance P	MESH:D002211	21333(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of prenatal capsaicin on the distribution of substance_P in developing primary afferent neurons .
7507995	0	capsaicin	61,70	substance_P	28,39	capsaicin	substance P	MESH:D002211	21333(Tax:10090)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of the NH2-terminus of substance_P in the inhibition by capsaicin of behavioral sensitization to kainic_acid-induced activity in the adult mouse .
7509392	0	capsaicin	29,38	substance_P	90,101	capsaicin	substance P	MESH:D002211	21333(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY mediated|nsubj|effect mediated|nmod|NH2-terminus NH2-terminus|nmod|END_ENTITY	An antinociceptive effect of capsaicin in the adult mouse mediated by the NH2-terminus of substance_P .
9231870	0	capsaicin	139,148	substance_P	14,25	capsaicin	substance P	MESH:D002211	21333(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY mediate|dobj|effect mediate|nsubj|Inhibition Inhibition|nmod|release release|compound|END_ENTITY	Inhibition of substance_P release from spinal cord tissue after pretreatment with capsaicin does not mediate the antinociceptive effect of capsaicin in adult mice .
9231870	0	capsaicin	82,91	substance_P	14,25	capsaicin	substance P	MESH:D002211	21333(Tax:10090)	Chemical	Gene	pretreatment|nmod|START_ENTITY tissue|nmod|pretreatment release|nmod|tissue release|compound|END_ENTITY	Inhibition of substance_P release from spinal cord tissue after pretreatment with capsaicin does not mediate the antinociceptive effect of capsaicin in adult mice .
11418494	0	capsaicin	49,58	substance_p	96,107	capsaicin	substance p	MESH:D002211	21333(Tax:10090)	Chemical	Gene	assess|nmod|START_ENTITY model|acl|assess model|dep|increased increased|nmod|mice mice|acl|lacking lacking|dobj|END_ENTITY	An animal model to assess aversion to intra-oral capsaicin : increased threshold in mice lacking substance_p .
21852608	0	capsaicin	66,75	transient_receptor_potential_vanilloid_1	14,54	capsaicin	transient receptor potential vanilloid 1	MESH:D002211	83810(Tax:10116)	Chemical	Gene	delays|compound|START_ENTITY END_ENTITY|nmod|delays	Activation of transient_receptor_potential_vanilloid_1 by dietary capsaicin delays the onset of stroke in stroke-prone spontaneously hypertensive rats .
23796768	0	capsaicin	52,61	transient_receptor_potential_vanilloid_1	142,182	capsaicin	transient receptor potential vanilloid 1	MESH:D002211	7442	Chemical	Gene	analogues|amod|START_ENTITY Design|nmod|analogues based|nsubj|Design reveal|advcl|based reveal|dobj|family family|nmod|antagonists antagonists|amod|END_ENTITY	Design and synthesis of conformationally restricted capsaicin analogues based in the 1 , _ 3 , _ 4-thiadiazole heterocycle reveal a novel family of transient_receptor_potential_vanilloid_1 -LRB- TRPV1 -RRB- antagonists .
24174527	0	capsaicin	123,132	transient_receptor_potential_vanilloid_1	28,68	capsaicin	transient receptor potential vanilloid 1	MESH:D002211	7442	Chemical	Gene	desensitization|amod|START_ENTITY involved|nmod|desensitization contains|xcomp|involved contains|nsubj|domain domain|nmod|END_ENTITY	Carboxyl-terminal domain of transient_receptor_potential_vanilloid_1 contains distinct segments differentially involved in capsaicin - and heat-induced desensitization .
18617618	0	capsaicin	138,147	transient_receptor_potential_vanilloid_receptor_1	74,123	capsaicin	transient receptor potential vanilloid receptor 1	MESH:D002211	83810(Tax:10116)	Chemical	Gene	inhibits|nmod|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	17beta-estradiol activates estrogen receptor beta-signalling and inhibits transient_receptor_potential_vanilloid_receptor_1 activation by capsaicin in adult rat nociceptor neurons .
14960593	0	capsazepine	80,91	TRPV1	117,122	capsazepine	TRPV1	MESH:C071423	7442	Chemical	Gene	action|nmod|START_ENTITY determinants|nmod|action Identification|nmod|determinants PPAHV|nsubj|Identification PPAHV|nmod|END_ENTITY	Identification of species-specific determinants of the action of the antagonist capsazepine and the agonist PPAHV on TRPV1 .
17522523	1	capsazepine	268,279	TRPV1	195,200	capsazepine	TRPV1	MESH:C071423	83810(Tax:10116)	Chemical	Gene	TRPV1|amod|START_ENTITY using|dobj|TRPV1 model|acl|using role|dep|model role|nmod|transient_receptor_potential_vanilloid_1 transient_receptor_potential_vanilloid_1|appos|END_ENTITY	OBJECTIVE : To evaluate the role of transient_receptor_potential_vanilloid_1 -LRB- TRPV1 -RRB- in a rat hemorrhagic_shock -LRB- HS -RRB- model using the TRPV1 antagonist , capsazepine -LRB- CPZ -RRB- .
25242870	0	capsazepine	20,31	TRPV1	0,5	capsazepine	TRPV1	MESH:C071423	193034(Tax:10090)	Chemical	Gene	modulates|amod|START_ENTITY antagonism|nmod|modulates antagonism|compound|END_ENTITY	TRPV1 antagonism by capsazepine modulates innate immune response in mice infected with Plasmodium_berghei_ANKA .
17522523	0	capsazepine	53,64	Transient_receptor_potential_vanilloid_1	0,40	capsazepine	Transient receptor potential vanilloid 1	MESH:C071423	83810(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Transient_receptor_potential_vanilloid_1 antagonist , capsazepine , improves survival in a rat hemorrhagic_shock model .
9881874	0	capsazepine	33,44	capsaicin-receptor	2,20	capsazepine	capsaicin-receptor	MESH:C071423	83810(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	A capsaicin-receptor antagonist , capsazepine , reduces inflammation-induced hyperalgesic responses in the rat : evidence for an endogenous capsaicin-like substance .
20719804	0	capsazepine	11,22	transient_receptor_potential_vanilloid_type_1	26,71	capsazepine	transient receptor potential vanilloid type 1	MESH:C071423	193034(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Effects of capsazepine , a transient_receptor_potential_vanilloid_type_1 antagonist , on morphine-induced antinociception , tolerance , and dependence in mice .
12009313	0	capsidiol	65,74	5-epi-aristolochene_synthase	19,47	capsidiol	5-epi-aristolochene synthase	MESH:C081843	104229039	Chemical	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Gene expression of 5-epi-aristolochene_synthase and formation of capsidiol in roots of Nicotiana attenuata and N. _ sylvestris .
10598120	0	captopril	144,153	ACE	124,127	captopril	ACE	CHEBI:3380	1636	Chemical	Gene	does|nmod|START_ENTITY does|dobj|inhibition inhibition|compound|END_ENTITY	Vasopeptidase inhibition with omapatrilat improves cardiac geometry and survival in cardiomyopathic_hamsters more than does ACE inhibition with captopril .
11522042	0	captopril	24,33	ACE	10,13	captopril	ACE	CHEBI:3380	24310(Tax:10116)	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|Effect Effect|nmod|END_ENTITY	Effect of ACE inhibitor captopril and L-arginine on the metabolism and on ischemia-reperfusion injury of the isolated rat heart .
11928278	0	captopril	20,29	ACE	5,8	captopril	ACE	CHEBI:3380	1636	Chemical	Gene	inhibitor|dep|START_ENTITY inhibitor|compound|END_ENTITY	-LSB- The ACE inhibitor , captopril , in the light of new clinical studies -RSB- .
12163343	0	captopril	19,28	ACE	94,97	captopril	ACE	CHEBI:3380	24310(Tax:10116)	Chemical	Gene	Renal|nmod|START_ENTITY enhances|nsubj|Renal enhances|dobj|inhibition inhibition|amod|intrarenal intrarenal|nmod|effects effects|nmod|END_ENTITY	Renal targeting of captopril selectively enhances the intrarenal over the systemic effects of ACE inhibition in rats .
12832683	0	captopril	11,20	ACE	105,108	captopril	ACE	CHEBI:3380	1636	Chemical	Gene	administration|amod|START_ENTITY Effects|nmod|administration oxygenation|nsubj|Effects oxygenation|nmod|exercise exercise|nmod|subtypes subtypes|compound|END_ENTITY	Effects of captopril administration on pulmonary haemodynamics and tissue oxygenation during exercise in ACE gene subtypes in patients with COPD : a preliminary study .
16424790	0	captopril	14,23	ACE	127,130	captopril	ACE	CHEBI:3380	11421(Tax:10090)	Chemical	Gene	Comparison|nmod|START_ENTITY Comparison|acl|study study|nmod|END_ENTITY	Comparison of captopril and enalapril to study the role of the sulfhydryl-group in improvement of endothelial_dysfunction with ACE inhibitors in high dieted methionine mice .
17433647	0	captopril	129,138	ACE	0,3	captopril	ACE	CHEBI:3380	24310(Tax:10116)	Chemical	Gene	extract|parataxis|START_ENTITY extract|nsubj|activity activity|compound|END_ENTITY	ACE activity during the hypotension produced by standardized aqueous extract of Cecropia glaziovii Sneth : a comparative study to captopril effects in rats .
1820294	0	captopril	71,80	ACE	57,60	captopril	ACE	CHEBI:3380	1636	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Prognosis of mild chronic_heart_failure : effects of the ACE inhibitor captopril -RSB- .
1834331	0	captopril	39,48	ACE	19,22	captopril	ACE	CHEBI:3380	1636	Chemical	Gene	factor|amod|START_ENTITY inhibition|nmod|factor inhibition|nsubj|Relations Relations|nmod|END_ENTITY	-LSB- Relations between ACE inhibition with captopril and atrial natriuretic factor during an acute hemodynamic study -RSB- .
23959119	0	captopril	20,29	ACE	0,3	captopril	ACE	CHEBI:3380	1636	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	ACE inhibition with captopril retards the development of signs of neurodegeneration in an animal model of Alzheimer 's _ disease .
2487803	0	captopril	76,85	ACE	60,63	captopril	ACE	CHEBI:3380	1636	Chemical	Gene	inhibition|dep|START_ENTITY inhibition|nsubj|blockade blockade|nmod|combination combination|nmod|END_ENTITY	Calcium-channel blockade -LRB- nitrendipine -RRB- in combination with ACE inhibition -LRB- captopril -RRB- in the treatment of mild to moderate hypertension .
2557660	0	captopril	10,19	ACE	58,61	captopril	ACE	CHEBI:3380	1636	Chemical	Gene	medication|amod|START_ENTITY Effect|nmod|medication END_ENTITY|nsubj|Effect	Effect of captopril and enalapril medication on the serum ACE test for sarcoidosis .
3005681	0	captopril	30,39	ACE	124,127	captopril	ACE	CHEBI:3380	613133(Tax:9823)	Chemical	Gene	comparison|nmod|START_ENTITY Pharmacological|dobj|comparison Pharmacological|nmod|method method|acl|measuring measuring|dobj|activity activity|nmod|angiotensin angiotensin|acl|converting converting|dobj|enzyme enzyme|appos|END_ENTITY	Pharmacological comparison of captopril and MK-422 by a new method for measuring activity of angiotensin converting enzyme -LRB- ACE -RRB- .
3026689	0	captopril	46,55	ACE	66,69	captopril	ACE	CHEBI:3380	1636	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Competitive inhibitor binding assay -LRB- CIBA -RRB- of captopril and other ACE inhibitors .
7500799	0	captopril	101,110	ACE	87,90	captopril	ACE	CHEBI:3380	613133(Tax:9823)	Chemical	Gene	START_ENTITY|nsubj|Significance Significance|nmod|timing timing|nmod|effects effects|nmod|therapy therapy|nmod|inhibitor inhibitor|compound|END_ENTITY	-LSB- Significance of therapy timing for the effects of systemic and local therapy with the ACE inhibitor captopril on intestinal microcirculation in manifest mesenteric_ischemia .
7619667	0	captopril	66,75	ACE	51,54	captopril	ACE	CHEBI:3380	1636	Chemical	Gene	inhibitors|xcomp|START_ENTITY inhibitors|nsubj|Bronchospasm Bronchospasm|nmod|reactions reactions|nmod|END_ENTITY	Bronchospasm and cough as adverse reactions to the ACE inhibitors captopril , enalapril and lisinopril .
8097091	3	captopril	468,477	ACE	452,455	captopril	ACE	CHEBI:3380	24310(Tax:10116)	Chemical	Gene	treatment|dep|START_ENTITY treatment|nmod|inhibitors inhibitors|compound|END_ENTITY	Chronic treatment with ACE inhibitors -LRB- captopril or lisinopril -RRB- for 25 days , followed by 1 day without treatment , increased plasma ACE , but only slightly modified lung , aorta , heart and kidney specific ACE activity .
8649134	0	captopril	24,33	ACE	38,41	captopril	ACE	CHEBI:3380	1636	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	-LSB- Hemodynamic effects of captopril , an ACE inhibitor , in patients after aortocoronary bypass -RSB- .
9175047	0	captopril	15,24	ACE	0,3	captopril	ACE	CHEBI:3380	1636	Chemical	Gene	regression|amod|START_ENTITY inhibitors|dobj|regression inhibitors|nsubj|END_ENTITY	ACE inhibitors captopril and enalapril induce regression of left_ventricular_hypertrophy in hypertensive patients with chronic_renal_failure .
9196851	0	captopril	62,71	ACE	46,49	captopril	ACE	CHEBI:3380	554335(Tax:9940)	Chemical	Gene	inhibitor|dep|START_ENTITY inhibitor|nsubj|Effects Effects|nmod|angiotensin_converting_enzyme angiotensin_converting_enzyme|appos|END_ENTITY	Effects of the angiotensin_converting_enzyme -LRB- ACE -RRB- inhibitor , captopril , on the cardiovascular , endocrine , and renal responses to furosemide in conscious lambs .
9676717	0	captopril	137,146	ACE	90,93	captopril	ACE	CHEBI:3380	1636	Chemical	Gene	targets|nmod|START_ENTITY provides|dobj|targets provides|nsubj|END_ENTITY	Enhanced_reduction of atherosclerosis in hamsters treated with pravastatin and captopril : ACE in atheromas provides cellular targets for captopril .
9789984	0	captopril	40,49	ACE	26,29	captopril	ACE	CHEBI:3380	1636	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|inhibitor inhibitor|compound|END_ENTITY	-LSB- Beneficial effect of the ACE inhibitor captopril in normotensive patients with insulin-dependent_diabetes -RSB- .
3521328	0	captopril	31,40	ADH	51,54	captopril	ADH	CHEBI:3380	551	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Angiotensin_II inhibition with captopril on plasma ADH , PG synthesis , and renal function in humans .
26027826	0	captopril	93,102	Angiotensin-converting_enzyme	53,82	captopril	Angiotensin-converting enzyme	D002216	11421(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Involvement Involvement|nmod|system system|nmod|damage damage|nmod|inhibitor inhibitor|amod|END_ENTITY	Involvement of Renin-Angiotensin system in damage of Angiotensin-converting_enzyme inhibitor captopril on bone of normal mice .
17413889	0	captopril	15,24	Angiotensin_II	0,14	captopril	Angiotensin II	CHEBI:3380	24179(Tax:10116)	Chemical	Gene	augments|compound|START_ENTITY augments|compound|END_ENTITY	Angiotensin_II captopril cotreatment augments angiogenesis in abdominal skin flap in rats .
3521328	0	captopril	31,40	Angiotensin_II	0,14	captopril	Angiotensin II	CHEBI:3380	183	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|END_ENTITY	Angiotensin_II inhibition with captopril on plasma ADH , PG synthesis , and renal function in humans .
6388325	0	captopril	81,90	Angiotensin_II	0,14	captopril	Angiotensin II	CHEBI:3380	183	Chemical	Gene	function|nmod|START_ENTITY function|nsubj|levels levels|compound|END_ENTITY	Angiotensin_II levels , hemodynamics , and sympathoadrenal function after low-dose captopril in heart_failure .
7014601	0	captopril	107,116	Angiotensin_II	0,14	captopril	Angiotensin II	CHEBI:3380	183	Chemical	Gene	therapy|amod|START_ENTITY evidence|nmod|therapy aldosterone|dep|evidence regulating|dobj|aldosterone potent|advcl|regulating potent|nsubj|END_ENTITY	Angiotensin_II is more potent than potassium in regulating aldosterone in cardiac_failure : evidence during captopril therapy .
9832171	0	captopril	44,53	Angiotensin_converting_enzyme	0,29	captopril	Angiotensin converting enzyme	CHEBI:3380	1636	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Angiotensin_converting_enzyme inhibition by captopril influences cardiac work in healthy hearts .
11738218	0	captopril	66,75	Bradykinin	0,10	captopril	Bradykinin	CHEBI:3380	3827	Chemical	Gene	infusion|nmod|START_ENTITY infusion|compound|END_ENTITY	Bradykinin infusion in chronic_cardiac_failure and the effects of captopril .
21155278	0	captopril	76,85	Bradykinin_B1_receptor	1,23	captopril	Bradykinin B1 receptor	CHEBI:3380	81509(Tax:10116)	Chemical	Gene	-RSB-|amod|START_ENTITY effects|nmod|-RSB- reduces|dobj|effects reduces|nsubj|antagonist antagonist|amod|END_ENTITY	-LSB- Bradykinin_B1_receptor antagonist reduces the antiproliferative effects of captopril on cardiac fibroblasts in neonatal rats -RSB- .
8527265	0	captopril	10,19	MPG	64,67	captopril	MPG	CHEBI:3380	4350	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of captopril , enalaprilat and mercaptopropionyl_glycine -LRB- MPG -RRB- on the oxidative activity of human isolated neutrophils .
15646324	0	captopril	11,20	PTEN	38,42	captopril	PTEN	CHEBI:3380	50557(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of captopril on expression of PTEN in aorta of aortic-induced hypertensive rats -RSB- .
2649097	0	captopril	71,80	Renin	0,5	captopril	Renin	CHEBI:3380	24715(Tax:10116)	Chemical	Gene	controlled|nmod|START_ENTITY controlled|nsubjpass|expression expression|compound|END_ENTITY	Renin expression in the kidney and brain is reciprocally controlled by captopril .
3893341	0	captopril	18,27	Renin	0,5	captopril	Renin	CHEBI:3380	403838(Tax:9615)	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Renin response to captopril in conscious dogs pretreated with indomethacin or propranolol .
20622326	0	captopril	57,66	SDF1	34,38	captopril	SDF1	CHEBI:3380	6387	Chemical	Gene	Impact|nmod|START_ENTITY Impact|nmod|END_ENTITY	Impact of genetic polymorphism of SDF1 3A on efficacy of captopril in Chinese patients with essential hypertension .
25441992	0	captopril	10,19	TNF-a	29,34	captopril	TNF-a	CHEBI:3380	24835(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|level level|amod|END_ENTITY	Effect of captopril on serum TNF-a level in acute_lung_injury rats induced by HCL .
3526857	0	captopril	62,71	Vasopressin	0,11	captopril	Vasopressin	CHEBI:3380	551	Chemical	Gene	administration|amod|START_ENTITY levels|nmod|administration levels|compound|END_ENTITY	Vasopressin , renin and norepinephrine levels before and after captopril administration in patients with congestive_heart_failure due to idiopathic_dilated_cardiomyopathy .
3003300	0	captopril	52,61	adrenocorticotrophic_hormone	8,36	captopril	adrenocorticotrophic hormone	CHEBI:3380	5443	Chemical	Gene	treatment|amod|START_ENTITY END_ENTITY|nmod|treatment	Blunted adrenocorticotrophic_hormone release during captopril treatment .
2649017	0	captopril	4,13	aid	23,26	captopril	aid	CHEBI:3380	57379	Chemical	Gene	test|amod|START_ENTITY test|dep|END_ENTITY	The captopril test : an aid to investigation of hypertension .
6086518	0	captopril	84,93	angiotensin-converting-enzyme	40,69	captopril	angiotensin-converting-enzyme	CHEBI:3380	1636	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Dilation of forearm blood vessels after angiotensin-converting-enzyme inhibition by captopril in hypertensive patients .
6291563	0	captopril	68,77	angiotensin-converting-enzyme	22,51	captopril	angiotensin-converting-enzyme	CHEBI:3380	1636	Chemical	Gene	efficacy|nmod|START_ENTITY efficacy|nmod|inhibition inhibition|amod|END_ENTITY	Long-term efficacy of angiotensin-converting-enzyme inhibition with captopril in mild-to-moderate essential hypertension .
1329477	0	captopril	95,104	angiotensin-converting_enzyme	12,41	captopril	angiotensin-converting enzyme	CHEBI:3380	1636	Chemical	Gene	lisinopril|nmod|START_ENTITY inhibition|dep|lisinopril inhibition|amod|END_ENTITY	Long-acting angiotensin-converting_enzyme inhibition : once-daily lisinopril versus twice-daily captopril in mild-to-moderate heart_failure .
1330641	0	captopril	35,44	angiotensin-converting_enzyme	48,77	captopril	angiotensin-converting enzyme	CHEBI:3380	24310(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	Effects of intracerebroventricular captopril on angiotensin-converting_enzyme and angiotensinogen mRNA levels in rat brain .
1545080	0	captopril	100,109	angiotensin-converting_enzyme	54,83	captopril	angiotensin-converting enzyme	CHEBI:3380	1636	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Effect of direct vasodilation with hydralazine versus angiotensin-converting_enzyme inhibition with captopril on mortality in advanced heart_failure : the Hy-C trial .
22591316	0	captopril	58,67	angiotensin-converting_enzyme	14,43	captopril	angiotensin-converting enzyme	CHEBI:3380	24310(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|inhibition inhibition|amod|END_ENTITY	The effect of angiotensin-converting_enzyme inhibition by captopril on respiratory mechanics in healthy rats .
2457768	0	captopril	111,120	angiotensin-converting_enzyme	65,94	captopril	angiotensin-converting enzyme	CHEBI:3380	1636	Chemical	Gene	assess|nmod|START_ENTITY assess|dobj|inhibition inhibition|amod|END_ENTITY	Plasma angiotensin - -LRB- 1-8 -RRB- octapeptide measurement to assess acute angiotensin-converting_enzyme inhibition with captopril administered parenterally to normal subjects .
2654304	0	captopril	10,19	angiotensin-converting_enzyme	24,53	captopril	angiotensin-converting enzyme	CHEBI:3380	1636	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|inhibitor inhibitor|amod|END_ENTITY	Effect of captopril -LRB- an angiotensin-converting_enzyme inhibitor -RRB- on intraocular pressure in healthy human volunteers .
2854903	0	captopril	91,100	angiotensin-converting_enzyme	15,44	captopril	angiotensin-converting enzyme	CHEBI:3380	24310(Tax:10116)	Chemical	Gene	Enhancement|nmod|START_ENTITY Enhancement|nmod|activity activity|amod|END_ENTITY	Enhancement of angiotensin-converting_enzyme activity in the inner cortex of rat kidney by captopril .
6206324	0	captopril	95,104	angiotensin-converting_enzyme	55,84	captopril	angiotensin-converting enzyme	CHEBI:3380	610668(Tax:9615)	Chemical	Gene	START_ENTITY|nsubj|H77 H77|nmod|inhibitor inhibitor|amod|END_ENTITY	In vivo comparison of the renin inhibitor H77 with the angiotensin-converting_enzyme inhibitor captopril .
6257100	0	captopril	63,72	angiotensin-converting_enzyme	17,46	captopril	angiotensin-converting enzyme	CHEBI:3380	1636	Chemical	Gene	therapy|amod|START_ENTITY inhibition|nmod|therapy inhibition|amod|END_ENTITY	Efficacy of oral angiotensin-converting_enzyme inhibition with captopril therapy in severe chronic normotensive congestive_heart_failure .
6277993	1	captopril	201,210	angiotensin-converting_enzyme	112,141	captopril	angiotensin-converting enzyme	CHEBI:3380	11421(Tax:10090)	Chemical	Gene	inflammation|nmod|START_ENTITY lavage|nmod|inflammation levels|nmod|lavage levels|amod|END_ENTITY	Increased angiotensin-converting_enzyme levels in lung lavage and suppression of inflammation with captopril .
6291358	0	captopril	128,137	angiotensin-converting_enzyme	82,111	captopril	angiotensin-converting enzyme	CHEBI:3380	1636	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Vasodilator therapy of severe congestive heart_failure : the special importance of angiotensin-converting_enzyme inhibition with captopril .
6291388	0	captopril	113,122	angiotensin-converting_enzyme	41,70	captopril	angiotensin-converting enzyme	CHEBI:3380	1636	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Hyperkalemia in azotemic patients during angiotensin-converting_enzyme inhibition and aldosterone reduction with captopril .
7485207	0	captopril	71,80	angiotensin-converting_enzyme	25,54	captopril	angiotensin-converting enzyme	CHEBI:3380	1636	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	The beneficial effect of angiotensin-converting_enzyme inhibition with captopril on diabetic_nephropathy in normotensive IDDM patients with microalbuminuria .
9276774	0	captopril	65,74	angiotensin-converting_enzyme	25,54	captopril	angiotensin-converting enzyme	CHEBI:3380	24310(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|inhibitor inhibitor|amod|END_ENTITY	Protective effect of the angiotensin-converting_enzyme inhibitor captopril on postischemic_myocardial_damage in perfused rat heart .
14530469	0	captopril	15,24	angiotensin_II	75,89	captopril	angiotensin II	CHEBI:3380	183	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|therapy therapy|nmod|END_ENTITY	Reliability of captopril renography in patients under chronic therapy with angiotensin_II -LRB- AT1 -RRB- receptor antagonists .
1505601	0	captopril	75,84	angiotensin_II	114,128	captopril	angiotensin II	CHEBI:3380	183	Chemical	Gene	response|nmod|START_ENTITY Lack|nmod|response Lack|nmod|END_ENTITY	Lack of correlation between the acute haemodynamic response to intravenous captopril and plasma concentrations of angiotensin_II in patients with chronic_cardiac_failure .
1565813	0	captopril	114,123	angiotensin_II	15,29	captopril	angiotensin II	CHEBI:3380	183	Chemical	Gene	effect|nmod|START_ENTITY formation|dep|effect formation|compound|END_ENTITY	Transpulmonary angiotensin_II formation and pulmonary haemodynamics in stable hypoxic_lung_disease : the effect of captopril .
1646165	0	captopril	97,106	angiotensin_II	13,27	captopril	angiotensin II	CHEBI:3380	24179(Tax:10116)	Chemical	Gene	antagonist|xcomp|START_ENTITY antagonist|nsubj|Effect Effect|nmod|END_ENTITY	Effect of an angiotensin_II and a kinin receptor antagonist on the renal hemodynamic response to captopril .
17004021	0	captopril	25,34	angiotensin_II	69,83	captopril	angiotensin II	CHEBI:3380	183	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|levels levels|amod|END_ENTITY	The effect of sublingual captopril versus intravenous enalaprilat on angiotensin_II plasma levels .
2668502	0	captopril	30,39	angiotensin_II	94,108	captopril	angiotensin II	CHEBI:3380	24179(Tax:10116)	Chemical	Gene	mechanism|nmod|START_ENTITY mechanism|dep|studies studies|nmod|antagonist antagonist|amod|END_ENTITY	Antihypertensive mechanism of captopril in renal hypertensive rats : studies with a nonpeptide angiotensin_II receptor antagonist and an angiotensin_II monoclonal antibody .
3030763	0	captopril	22,31	angiotensin_II	115,129	captopril	angiotensin II	CHEBI:3380	183	Chemical	Gene	therapy|amod|START_ENTITY effect|nmod|therapy effect|nmod|infusion infusion|amod|END_ENTITY	The effect of chronic captopril therapy on platelet angiotensin_II receptor density and vascular responsiveness to angiotensin_II infusion .
3030763	0	captopril	22,31	angiotensin_II	52,66	captopril	angiotensin II	CHEBI:3380	183	Chemical	Gene	therapy|amod|START_ENTITY effect|nmod|therapy effect|nmod|density density|compound|END_ENTITY	The effect of chronic captopril therapy on platelet angiotensin_II receptor density and vascular responsiveness to angiotensin_II infusion .
3331474	0	captopril	103,112	angiotensin_II	74,88	captopril	angiotensin II	CHEBI:3380	183	Chemical	Gene	infusion|nmod|START_ENTITY infusion|nmod|inhibition inhibition|amod|END_ENTITY	Effects of PGE2 infusion on renal function in normal man before and after angiotensin_II inhibition by captopril .
3514745	0	captopril	77,86	angiotensin_II	23,37	captopril	angiotensin II	CHEBI:3380	24179(Tax:10116)	Chemical	Gene	rats|amod|START_ENTITY action|nmod|rats perfusion|nmod|action perfusion|nsubj|Effect Effect|nmod|doses doses|nmod|END_ENTITY	Effect of low doses of angiotensin_II perfusion on the hypotensive action of captopril in anaesthetized normotensive and spontaneously hypertensive rats .
3534868	0	captopril	62,71	angiotensin_II	20,34	captopril	angiotensin II	CHEBI:3380	183	Chemical	Gene	therapy|amod|START_ENTITY year|nmod|therapy END_ENTITY|nmod|year	Effect of exogenous angiotensin_II infusion after one year of captopril therapy in essential hypertension .
6167515	1	captopril	176,185	angiotensin_II	113,127	captopril	angiotensin II	CHEBI:3380	183	Chemical	Gene	Implication|nmod|START_ENTITY Implication|nmod|END_ENTITY	Implication of vascular angiotensin_II in hypertension and antihypertensive actions of captopril .
6317552	0	captopril	13,22	angiotensin_II	36,50	captopril	angiotensin II	CHEBI:3380	24179(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY Influence|nmod|treatment Influence|nmod|receptors receptors|amod|END_ENTITY	Influence of captopril treatment on angiotensin_II receptors and angiotensinogen in the brain of spontaneously hypertensive rats .
6380316	0	captopril	23,32	angiotensin_II	56,70	captopril	angiotensin II	CHEBI:3380	24179(Tax:10116)	Chemical	Gene	blockade|amod|START_ENTITY blockade|nmod|formation formation|compound|END_ENTITY	Sodium_appetite during captopril blockade of endogenous angiotensin_II formation .
6985575	0	captopril	160,169	angiotensin_II	85,99	captopril	angiotensin II	CHEBI:3380	183	Chemical	Gene	responses|dep|START_ENTITY responses|nmod|antagonism antagonism|nmod|END_ENTITY	Constrasts and similarities of acute hemodynamic responses to specific antagonism of angiotensin_II -LRB- -LSB- Sar1 , Thr8 -RSB- A II -RRB- and to inhibition of converting enzyme -LRB- captopril -RRB- .
7032817	0	captopril	58,67	angiotensin_II	10,24	captopril	angiotensin II	CHEBI:3380	183	Chemical	Gene	inhibitor|dep|START_ENTITY END_ENTITY|dobj|inhibitor	Effect of angiotensin_II and converting enzyme inhibitor -LRB- captopril -RRB- on blood pressure , plasma renin activity and aldosterone in primary_aldosteronism .
8206610	0	captopril	145,154	angiotensin_II	17,31	captopril	angiotensin II	CHEBI:3380	24179(Tax:10116)	Chemical	Gene	hypertensive|nmod|START_ENTITY hypertensive|nsubj|Changes Changes|nmod|receptors receptors|compound|END_ENTITY	Changes in renal angiotensin_II receptors in spontaneously hypertensive rats by early treatment with the angiotensin-converting enzyme inhibitor captopril .
10999062	0	captopril	10,19	angiotensin_converting_enzyme	29,58	captopril	angiotensin converting enzyme	CHEBI:3380	1636	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of captopril on serum angiotensin_converting_enzyme and blood pressure in hypertensive patients .
15858644	0	captopril	110,119	angiotensin_converting_enzyme	69,98	captopril	angiotensin converting enzyme	CHEBI:3380	1636	Chemical	Gene	reaction|appos|START_ENTITY reaction|appos|L-penicillamine L-penicillamine|nmod|inhibitor inhibitor|amod|END_ENTITY	The reaction of S-nitroso-N-acetyl-D , L-penicillamine -LRB- SNAP -RRB- with the angiotensin_converting_enzyme inhibitor , captopril -- mechanism of transnitrosation .
1653709	0	captopril	111,120	angiotensin_converting_enzyme	21,50	captopril	angiotensin converting enzyme	CHEBI:3380	11421(Tax:10090)	Chemical	Gene	influence|nmod|START_ENTITY mice|nmod|influence activity|nmod|mice activity|amod|END_ENTITY	Schistosoma_mansoni : angiotensin_converting_enzyme activity in mice under the influence of praziquantel and/or captopril .
1847704	0	captopril	156,165	angiotensin_converting_enzyme	22,51	captopril	angiotensin converting enzyme	CHEBI:3380	1636	Chemical	Gene	enhances|advcl|START_ENTITY enhances|nsubj|Effects Effects|nmod|changes changes|nmod|activity activity|amod|END_ENTITY	Effects of changes in angiotensin_converting_enzyme activity on renin release : pretreatment with dexamethasone enhances a plasma renin activity response to captopril in normal subjects .
2156640	0	captopril	54,63	angiotensin_converting_enzyme	13,42	captopril	angiotensin converting enzyme	CHEBI:3380	610668(Tax:9615)	Chemical	Gene	inhibitor|dep|START_ENTITY inhibitor|amod|END_ENTITY	Influence of angiotensin_converting_enzyme inhibitor -LRB- captopril -RRB- on kidney epithelial cells in vitro : studies on potassium -LRB- 86Rb -RRB- influx and cellular proliferation .
21629912	0	captopril	24,33	angiotensin_converting_enzyme	47,76	captopril	angiotensin converting enzyme	CHEBI:3380	1636	Chemical	Gene	Effect|nmod|START_ENTITY analogues|nsubj|Effect analogues|nmod|activity activity|amod|END_ENTITY	Effect of peptide-based captopril analogues on angiotensin_converting_enzyme activity and peroxynitrite-mediated tyrosine nitration .
2285027	0	captopril	24,33	angiotensin_converting_enzyme	53,82	captopril	angiotensin converting enzyme	CHEBI:3380	11421(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|inhibitors inhibitors|amod|END_ENTITY	Differential effects of captopril and enalapril , two angiotensin_converting_enzyme inhibitors , on immune reactivity in experimental lupus_disease .
2427810	0	captopril	133,142	angiotensin_converting_enzyme	75,104	captopril	angiotensin converting enzyme	CHEBI:3380	24310(Tax:10116)	Chemical	Gene	comparison|nmod|START_ENTITY Reduction|dep|comparison Reduction|nmod|arrhythmias arrhythmias|nmod|heart heart|nmod|inhibitors inhibitors|amod|END_ENTITY	Reduction of reperfusion arrhythmias in the ischemic isolated rat heart by angiotensin_converting_enzyme inhibitors : a comparison of captopril , enalapril , and HOE_498 .
25703442	0	captopril	45,54	angiotensin_converting_enzyme	4,33	captopril	angiotensin converting enzyme	CHEBI:3380	11421(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	The angiotensin_converting_enzyme inhibitor , captopril , prevents the hyperactivity and impulsivity of neurokinin-1 receptor gene ` knockout ' mice : Sex differences and implications for the treatment of attention_deficit_hyperactivity_disorder .
2983253	0	captopril	55,64	angiotensin_converting_enzyme	14,43	captopril	angiotensin converting enzyme	CHEBI:3380	1636	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Effect of the angiotensin_converting_enzyme inhibitor , captopril -LRB- SQ14 ,225 -RRB- , on orthostatic sodium and water retention in patients with idiopathic_edema .
2991497	0	captopril	12,21	angiotensin_converting_enzyme	69,98	captopril	angiotensin converting enzyme	CHEBI:3380	100009274(Tax:9986)	Chemical	Gene	inhibition|amod|START_ENTITY Kinetics|nmod|inhibition Kinetics|nmod|END_ENTITY	Kinetics of captopril - and enalapril-induced inhibition of pulmonary angiotensin_converting_enzyme in vivo .
3038992	0	captopril	11,20	angiotensin_converting_enzyme	30,59	captopril	angiotensin converting enzyme	CHEBI:3380	1636	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Acute oral captopril inhibits angiotensin_converting_enzyme activity in human cerebrospinal fluid .
3111758	0	captopril	51,60	angiotensin_converting_enzyme	10,39	captopril	angiotensin converting enzyme	CHEBI:3380	1636	Chemical	Gene	inhibitor|dep|START_ENTITY inhibitor|amod|END_ENTITY	Effect of angiotensin_converting_enzyme inhibitor -LRB- captopril -RRB- on cerebral blood flow in hypertensive patients without a history of stroke .
3293542	0	captopril	172,181	angiotensin_converting_enzyme	49,78	captopril	angiotensin converting enzyme	CHEBI:3380	24310(Tax:10116)	Chemical	Gene	comparison|nmod|START_ENTITY action|dep|comparison action|nmod|altiopril_calcium altiopril_calcium|compound|END_ENTITY	Antihypertensive action of a novel orally active angiotensin_converting_enzyme inhibitor altiopril_calcium -LRB- MC-838 -RRB- in several hypertensive models of rats : comparison with captopril .
6089313	0	captopril	45,54	angiotensin_converting_enzyme	79,108	captopril	angiotensin converting enzyme	CHEBI:3380	1636	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Competitive inhibitor binding assay -LRB- IBA -RRB- of captopril and other inhibitors of angiotensin_converting_enzyme .
6257882	0	captopril	29,38	angiotensin_converting_enzyme	82,111	captopril	angiotensin converting enzyme	CHEBI:3380	610668(Tax:9615)	Chemical	Gene	activity|nmod|START_ENTITY activity|appos|inhibitor inhibitor|nmod|dogs dogs|amod|END_ENTITY	Antihypertensive activity of captopril -LRB- SQ 14,225 -RRB- , an orally active inhibitor of angiotensin_converting_enzyme in conscious two-kidney perinephritic hypertensive dogs .
6303049	0	captopril	64,73	angiotensin_converting_enzyme	27,56	captopril	angiotensin converting enzyme	CHEBI:3380	24310(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY Effect|nmod|treatment Effect|nmod|END_ENTITY	Effect of time and dose on angiotensin_converting_enzyme during captopril treatment in the rat .
6324538	0	captopril	75,84	angiotensin_converting_enzyme	23,52	captopril	angiotensin converting enzyme	CHEBI:3380	24310(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY effect|nmod|treatment distribution|dep|effect distribution|nmod|END_ENTITY	Tissue distribution of angiotensin_converting_enzyme in the rat : effect of captopril treatment .
6327968	0	captopril	96,105	angiotensin_converting_enzyme	36,65	captopril	angiotensin converting enzyme	CHEBI:3380	100009274(Tax:9986)	Chemical	Gene	Correlation|nmod|START_ENTITY Correlation|nmod|END_ENTITY	Correlation between lung and plasma angiotensin_converting_enzyme and the hypotensive effect of captopril in conscious rabbits .
7865491	0	captopril	34,43	angiotensin_converting_enzyme	76,105	captopril	angiotensin converting enzyme	CHEBI:3380	24310(Tax:10116)	Chemical	Gene	treatment|nmod|START_ENTITY Effects|nmod|treatment END_ENTITY|nsubj|Effects	Effects of long-term treatment of captopril and enalapril on rat intestinal angiotensin_converting_enzyme specific activities .
8512657	0	captopril	65,74	angiotensin_converting_enzyme	25,54	captopril	angiotensin converting enzyme	CHEBI:3380	1636	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Long-term effects of the angiotensin_converting_enzyme inhibitor captopril on metabolic control in non-insulin-dependent diabetes_mellitus .
9196851	0	captopril	62,71	angiotensin_converting_enzyme	15,44	captopril	angiotensin converting enzyme	CHEBI:3380	554335(Tax:9940)	Chemical	Gene	inhibitor|dep|START_ENTITY inhibitor|nsubj|Effects Effects|nmod|END_ENTITY	Effects of the angiotensin_converting_enzyme -LRB- ACE -RRB- inhibitor , captopril , on the cardiovascular , endocrine , and renal responses to furosemide in conscious lambs .
9594434	0	captopril	66,75	angiotensin_converting_enzyme	14,43	captopril	angiotensin converting enzyme	CHEBI:3380	554335(Tax:9940)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of angiotensin_converting_enzyme from sheep tissues by captopril , lisinopril and enalapril .
6089318	0	captopril	35,44	angiotensins_I_and_II	82,103	captopril	angiotensins I and II	CHEBI:3380	183	Chemical	Gene	influence|nmod|START_ENTITY influence|nmod|END_ENTITY	The influence of ACE-inhibition by captopril on renal formation and metabolism of angiotensins_I_and_II in patients with renovascular_hypertension .
2847675	0	captopril	85,94	angiotensins_I_and_II_and_2	27,54	captopril	angiotensins I and II and 2	CHEBI:3380	24179(Tax:10116)	Chemical	Gene	effects|dep|START_ENTITY effects|nmod|END_ENTITY	-LSB- Direct cardiac effects of angiotensins_I_and_II_and_2 converting enzyme inhibitors -LRB- captopril and perindopril -RRB- .
2532136	0	captopril	10,19	bradykinin	61,71	captopril	bradykinin	CHEBI:3380	3827	Chemical	Gene	Effect|nmod|START_ENTITY flow|nsubj|Effect flow|nmod|END_ENTITY	Effect of captopril on skin blood flow following intradermal bradykinin measured by laser Doppler flowmetry .
3513809	0	captopril	10,19	bradykinin	23,33	captopril	bradykinin	CHEBI:3380	3827	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|inactivation inactivation|compound|END_ENTITY	Effect of captopril on bradykinin inactivation by human foetal placental circulation .
6998710	0	captopril	81,90	bradykinin	60,70	captopril	bradykinin	CHEBI:3380	3827	Chemical	Gene	treatment|amod|START_ENTITY END_ENTITY|nmod|treatment	Prostacyclin mediates the potentiated hypotensive effect of bradykinin following captopril treatment .
7669485	0	captopril	11,20	bradykinin	84,94	captopril	bradykinin	CHEBI:3380	3827	Chemical	Gene	Effects|nmod|START_ENTITY Effects|dep|interaction interaction|nmod|END_ENTITY	Effects of captopril on the human foetal placental circulation : an interaction with bradykinin and angiotensin_I .
8448072	0	captopril	31,40	bradykinin	88,98	captopril	bradykinin	CHEBI:3380	3827	Chemical	Gene	effects|nmod|START_ENTITY comparison|nmod|effects comparison|nmod|responses responses|nmod|END_ENTITY	A comparison of the effects of captopril and enalapril on skin responses to intradermal bradykinin and skin blood flow in the human forearm .
18710643	0	captopril	76,85	bradykinin_B1_receptor	25,47	captopril	bradykinin B1 receptor	CHEBI:3380	81509(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nmod|effect	Compensatory function of bradykinin_B1_receptor in the inhibitory effect of captopril on cardiomyocyte hypertrophy and cardiac fibroblast proliferation in neonatal rats .
9323436	0	captopril	22,31	c-fos	35,40	captopril	c-fos	CHEBI:3380	2353	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effect of intravenous captopril on c-fos expression induced by sodium depletion in neurons of the lamina terminalis .
10437140	0	captopril	22,31	c-myc	35,40	captopril	c-myc	CHEBI:3380	24577(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|amod|END_ENTITY	Inhibitory effects of captopril on c-myc expression during left_ventricular_hypertrophy .
8187357	0	captopril	51,60	endothelin-1	21,33	captopril	endothelin-1	CHEBI:3380	1906	Chemical	Gene	concentration|nmod|START_ENTITY concentration|amod|END_ENTITY	Inhibition of plasma endothelin-1 concentration by captopril in patients with essential hypertension .
23137627	0	captopril	84,93	nNOS	0,4	captopril	nNOS	CHEBI:3380	24598(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|expression expression|amod|END_ENTITY	nNOS expression in the brain of rats after burn and the effect of the ACE inhibitor captopril .
2192585	0	captopril	10,19	prolactin	30,39	captopril	prolactin	CHEBI:3380	5617	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of captopril on plasma prolactin in patients with essential hypertension .
10432403	0	captopril	18,27	renin	52,57	captopril	renin	CHEBI:3380	5972	Chemical	Gene	response|nmod|START_ENTITY reflects|nsubj|response reflects|dobj|state state|nmod|system system|compound|END_ENTITY	Renal response to captopril reflects state of local renin system in healthy humans .
1383634	0	captopril	156,165	renin	79,84	captopril	renin	CHEBI:3380	100724037	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|reduction reduction|nmod|pressure pressure|nmod|coadministration coadministration|nmod|inhibitor inhibitor|compound|END_ENTITY	Synergistic effect on reduction in blood pressure with coadministration of the renin inhibitor , CP-80 ,794 , and the angiotensin converting enzyme inhibitor , captopril .
1387500	0	captopril	80,89	renin	133,138	captopril	renin	CHEBI:3380	5972	Chemical	Gene	response|nmod|START_ENTITY evaluating|dobj|response evaluating|nmod|patients patients|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Long-term blood pressure measurement for evaluating the first dose response of captopril and ramipril in patients with a stimulated renin system -RSB- .
16087785	0	captopril	11,20	renin	28,33	captopril	renin	CHEBI:3380	24715(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|system system|amod|END_ENTITY	Effects of captopril on the renin angiotensin system , oxidative stress , and endothelin in normal and hypertensive rats .
1636021	0	captopril	10,19	renin	44,49	captopril	renin	CHEBI:3380	24715(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|excretion excretion|nmod|END_ENTITY	Effect of captopril on urinary excretion of renin and angiotensinogen in aminonucleoside nephrosis .
1663967	0	captopril	106,115	renin	10,15	captopril	renin	CHEBI:3380	5972	Chemical	Gene	comparison|nmod|START_ENTITY Effect|dep|comparison Effect|nmod|inhibitor inhibitor|compound|END_ENTITY	Effect of renin inhibitor , ES-8891 , on renal renin secretion and storage in the marmoset : comparison with captopril .
1663967	0	captopril	106,115	renin	45,50	captopril	renin	CHEBI:3380	5972	Chemical	Gene	comparison|nmod|START_ENTITY Effect|dep|comparison Effect|nmod|inhibitor inhibitor|nmod|secretion secretion|compound|END_ENTITY	Effect of renin inhibitor , ES-8891 , on renal renin secretion and storage in the marmoset : comparison with captopril .
1847704	0	captopril	156,165	renin	129,134	captopril	renin	CHEBI:3380	5972	Chemical	Gene	enhances|advcl|START_ENTITY enhances|dobj|response response|compound|END_ENTITY	Effects of changes in angiotensin_converting_enzyme activity on renin release : pretreatment with dexamethasone enhances a plasma renin activity response to captopril in normal subjects .
1847704	0	captopril	156,165	renin	64,69	captopril	renin	CHEBI:3380	5972	Chemical	Gene	enhances|advcl|START_ENTITY enhances|nsubj|Effects Effects|nmod|changes changes|nmod|activity activity|nmod|release release|compound|END_ENTITY	Effects of changes in angiotensin_converting_enzyme activity on renin release : pretreatment with dexamethasone enhances a plasma renin activity response to captopril in normal subjects .
1868475	0	captopril	11,20	renin	36,41	captopril	renin	CHEBI:3380	5972	Chemical	Gene	Use|nmod|START_ENTITY test|nsubj|Use test|xcomp|assess assess|dobj|responsiveness responsiveness|compound|END_ENTITY	Use of the captopril test to assess renin responsiveness in children with hypertension and renal_disease .
1893613	0	captopril	32,41	renin	59,64	captopril	renin	CHEBI:3380	102122446	Chemical	Gene	studies|nmod|START_ENTITY studies|appos|inhibitor inhibitor|compound|END_ENTITY	Additive combination studies of captopril and ditekiren , a renin inhibitor , in nonhuman primates .
2088587	0	captopril	11,20	renin	36,41	captopril	renin	CHEBI:3380	5972	Chemical	Gene	Use|nmod|START_ENTITY test|nsubj|Use test|xcomp|assess assess|dobj|responsiveness responsiveness|compound|END_ENTITY	Use of the captopril test to assess renin responsiveness in children with hypertension and renal_disease .
223756	0	captopril	10,19	renin	57,62	captopril	renin	CHEBI:3380	5972	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|activity activity|compound|END_ENTITY	Effect of captopril -LRB- SQ 14225 -RRB- on blood pressure , plasma renin activity and angiotensin I converting enzyme activity .
2650928	0	captopril	40,49	renin	22,27	captopril	renin	CHEBI:3380	403838(Tax:9615)	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Stimulation of plasma renin activity by captopril in renovascular_hypertensive conscious dogs .
3319647	0	captopril	10,19	renin	23,28	captopril	renin	CHEBI:3380	5972	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|pressure pressure|compound|END_ENTITY	Effect of captopril on renin and blood pressure in cirrhosis .
3512121	0	captopril	63,72	renin	166,171	captopril	renin	CHEBI:3380	5972	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|importance importance|nmod|activity activity|compound|END_ENTITY	Differential long-term intrarenal and neurohormonal effects of captopril and prazosin in patients with chronic congestive_heart_failure : importance of initial plasma renin activity .
3519017	0	captopril	94,103	renin	35,40	captopril	renin	CHEBI:3380	5972	Chemical	Gene	administration|nmod|START_ENTITY inactive|nmod|administration inactive|dobj|levels levels|compound|END_ENTITY	Dynamic changes in plasma inactive renin levels in Bartter 's _ syndrome after administration of captopril and angiotensin_II .
6099389	0	captopril	8,17	renin	75,80	captopril	renin	CHEBI:3380	24715(Tax:10116)	Chemical	Gene	infusion|amod|START_ENTITY infusion|appos|rats rats|nmod|concentration concentration|compound|END_ENTITY	Chronic captopril infusion in two-kidney , one clip rats with normal plasma renin concentration .
6167591	0	captopril	10,19	renin	46,51	captopril	renin	CHEBI:3380	5972	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of captopril and aprotinin on inactive renin .
6206324	0	captopril	95,104	renin	26,31	captopril	renin	CHEBI:3380	403838(Tax:9615)	Chemical	Gene	START_ENTITY|nmod|comparison comparison|nmod|inhibitor inhibitor|compound|END_ENTITY	In vivo comparison of the renin inhibitor H77 with the angiotensin-converting_enzyme inhibitor captopril .
6340244	0	captopril	32,41	renin	20,25	captopril	renin	CHEBI:3380	5972	Chemical	Gene	administration|amod|START_ENTITY Active|nmod|administration Active|dobj|END_ENTITY	Active and inactive renin after captopril -LRB- SQ_14225 -RRB- administration in hypertensive patients .
6351212	0	captopril	10,19	renin	107,112	captopril	renin	CHEBI:3380	5972	Chemical	Gene	Value|nmod|START_ENTITY Value|nmod|END_ENTITY	-LSB- Value of captopril in the treatment of systemic arterial and pulmonary_hypertension with increased plasma renin in scleroderma -RSB- .
6365362	0	captopril	41,50	renin	81,86	captopril	renin	CHEBI:3380	5972	Chemical	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Use of oral converting enzyme inhibitor , captopril for lateralizing renal venous renin activity .
6370512	0	captopril	23,32	renin	62,67	captopril	renin	CHEBI:3380	5972	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|compound|END_ENTITY	The effect of in vitro captopril and angiotensin_II on plasma renin activity .
6383845	0	captopril	104,113	renin	22,27	captopril	renin	CHEBI:3380	24715(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY effect|nmod|treatment Differences|dep|effect Differences|nmod|content content|compound|END_ENTITY	Differences in kidney renin content between normotensive and spontaneously hypertensive rats : effect of captopril treatment .
6392654	2	captopril	520,529	renin	547,552	captopril	renin	CHEBI:3380	403838(Tax:9615)	Chemical	Gene	dogs|nmod|START_ENTITY Pretreatment|nmod|dogs increased|nsubj|Pretreatment increased|dobj|activity activity|compound|END_ENTITY	Pretreatment of dogs with captopril increased plasma renin activity , but it did not affect systemic blood pressure , renal blood flow and renal vascular resistance .
6756706	0	captopril	10,19	renin	32,37	captopril	renin	CHEBI:3380	5972	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of captopril on inactive renin and contact phase of coagulation system .
6994184	0	captopril	69,78	renin	28,33	captopril	renin	CHEBI:3380	403838(Tax:9615)	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Relationship between plasma renin activity and hypotensive effect of captopril in dogs .
6997455	0	captopril	22,31	renin	54,59	captopril	renin	CHEBI:3380	24715(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|compound|END_ENTITY	Hypotensive effect of captopril in relation to plasma renin activity in anesthetized rats .
7007685	0	captopril	43,52	renin	24,29	captopril	renin	CHEBI:3380	5972	Chemical	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Exaggerated response of renin secretion to captopril -LRB- SQ_14225 -RRB- in renovascular_hypertension .
7009165	0	captopril	12,21	renin	42,47	captopril	renin	CHEBI:3380	24715(Tax:10116)	Chemical	Gene	Efficacy|nmod|START_ENTITY Efficacy|nmod|hypertension hypertension|compound|END_ENTITY	Efficacy of captopril in experimental low renin hypertension .
7018859	0	captopril	15,24	renin	104,109	captopril	renin	CHEBI:3380	5972	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activity activity|compound|END_ENTITY	The effects of captopril on blood pressure in essential hypertensive patients with low or normal plasma renin activity .
7041596	0	captopril	49,58	renin	20,25	captopril	renin	CHEBI:3380	5972	Chemical	Gene	dose|nmod|START_ENTITY Active|nmod|dose Active|dobj|END_ENTITY	Active and inactive renin after a single dose of captopril in hypertensive patients .
7042175	0	captopril	38,47	renin	63,68	captopril	renin	CHEBI:3380	5972	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activity activity|compound|END_ENTITY	Antihypertensive and renal effects of captopril in relation to renin activity and bradykinin-induced vasodilation .
7049508	0	captopril	42,51	renin	73,78	captopril	renin	CHEBI:3380	403838(Tax:9615)	Chemical	Gene	START_ENTITY|nmod|level level|compound|END_ENTITY	Dependence of renal vasodilator effect of captopril on prevailing plasma renin level in the dog : influence of DOCA-salt treatment .
7910062	0	captopril	86,95	renin	20,25	captopril	renin	CHEBI:3380	5972	Chemical	Gene	effect|nmod|START_ENTITY furosemide|dobj|effect responsiveness|xcomp|furosemide responsiveness|nsubj|Correlation Correlation|nmod|END_ENTITY	Correlation between renin responsiveness to furosemide and antihypertensive effect of captopril in patients with normal-renin essential hypertension .
7941572	0	captopril	138,147	renin	80,85	captopril	renin	CHEBI:3380	5972	Chemical	Gene	Concentrations|acl|START_ENTITY Concentrations|nmod|plasma plasma|acl|END_ENTITY	-LSB- Concentrations of kininogen and prekallikrein in plasma and activity of plasma renin depending on the type of blood pressure response to captopril in patients with arterial hypertension -RSB- .
8021469	0	captopril	16,25	renin	56,61	captopril	renin	CHEBI:3380	5972	Chemical	Gene	test|amod|START_ENTITY Response|nmod|test dependent|nsubj|Response dependent|nmod|profile profile|compound|END_ENTITY	Response to the captopril test is dependent on baseline renin profile .
8021469	12	captopril	1558,1567	renin	1540,1545	captopril	renin	CHEBI:3380	5972	Chemical	Gene	challenge|amod|START_ENTITY response|nmod|challenge response|compound|END_ENTITY	CONCLUSION : An exaggerated renin response to captopril challenge is common in patients with high-renin essential hypertension .
80634	0	captopril	43,52	renin	15,20	captopril	renin	D002216	5972	Chemical	Gene	unmasked|nmod|START_ENTITY unmasked|nsubj|secretion secretion|compound|END_ENTITY	Innappropriate renin secretion unmasked by captopril -LRB- SQ 14 225 -RRB- in hypertension of chronic_renal_failure .
8175172	0	captopril	17,26	renin	77,82	captopril	renin	CHEBI:3380	24715(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|gene gene|compound|END_ENTITY	Renal effects of captopril and nitrendipine in transgenic rats with an extra renin gene .
8272217	0	captopril	10,19	renin	43,48	captopril	renin	CHEBI:3380	5972	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|extraction extraction|nmod|END_ENTITY	Effect of captopril on renal extraction of renin , angiotensin_II , atrial natriuretic peptide and vasopressin , and renal vein renin ratio in patients with arterial hypertension and unilateral_renal_artery_disease .
11341938	0	captopril	10,19	tyrosinase	32,42	captopril	tyrosinase	CHEBI:3380	7299	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of captopril on mushroom tyrosinase activity in vitro .
2698964	0	captopril	32,41	vasopressin	64,75	captopril	vasopressin	CHEBI:3380	551	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of single-administration captopril on plasma and urinary vasopressin in normotensive subjects and patients with essential_hypertension and primary_aldosteronism .
22849721	0	carba-NAD	13,22	SIRT3	72,77	carba-NAD	SIRT3	MESH:C055311	23410	Chemical	Gene	Synthesis|nmod|START_ENTITY Synthesis|nmod|END_ENTITY	Synthesis of carba-NAD and the structures of its ternary complexes with SIRT3 and SIRT5 .
11069606	0	carbachol	81,90	CA3	67,70	carbachol	CA3	MESH:D002217	54232(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nmod|region region|compound|END_ENTITY	A model of gamma-frequency_network_oscillations induced in the rat CA3 region by carbachol in vitro .
8180563	0	carbachol	102,111	acetylcholinesterase	64,84	carbachol	acetylcholinesterase	MESH:D002217	43	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of high hydrostatic pressures on secondary structure of acetylcholinesterase with and without carbachol .
15893601	0	carbachol	98,107	c-fos	54,59	carbachol	c-fos	MESH:D002217	2353	Chemical	Gene	microinjection|nmod|START_ENTITY induced|nmod|microinjection expression|acl|induced expression|nmod|END_ENTITY	From synapse to gene product : prolonged expression of c-fos induced by a single microinjection of carbachol in the pontomesencephalic tegmentum .
7476883	0	carbachol	144,153	c-fos	80,85	carbachol	c-fos	MESH:D002217	14281(Tax:10090)	Chemical	Gene	treatment|nmod|START_ENTITY element-binding|nmod|treatment element-binding|dobj|protein protein|nmod|expression expression|amod|END_ENTITY	Phosphorylation of cyclic_AMP response element-binding protein and induction of c-fos gene expression on withdrawal from chronic treatment with carbachol in NG108-15 cells .
7800852	0	carbachol	132,141	chromogranin_A	28,42	carbachol	chromogranin A	MESH:D002217	1113	Chemical	Gene	Production|nmod|START_ENTITY Production|nmod|END_ENTITY	Production and secretion of chromogranin_A and pancreastatin by the human pancreatic_carcinoma cell line QGP-1N on stimulation with carbachol .
6193153	0	carbachol	96,105	cyclic_nucleotide_phosphodiesterase	12,47	carbachol	cyclic nucleotide phosphodiesterase	MESH:D002217	5140	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of cyclic_nucleotide_phosphodiesterase in the inhibition of cyclic_AMP accumulation by carbachol and phosphatidate .
12202486	0	carbachol	87,96	epidermal_growth_factor_receptor	23,55	carbachol	epidermal growth factor receptor	MESH:D002217	1956	Chemical	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	Transactivation of the epidermal_growth_factor_receptor in colonic epithelial cells by carbachol requires extracellular release of transforming_growth_factor-alpha .
1265437	0	carbachol	14,23	gastrin	83,90	carbachol	gastrin	MESH:D002217	2520	Chemical	Gene	pressure|amod|START_ENTITY effect|nmod|pressure END_ENTITY|nsubj|effect	The effect of carbachol on resting gastro-oesophageal sphincter pressure and serum gastrin in normal human subjects .
2877911	0	carbachol	108,117	gastrin	163,170	carbachol	gastrin	MESH:D002217	25320(Tax:10116)	Chemical	Gene	bombesin|compound|START_ENTITY effect|nmod|bombesin effect|nmod|release release|compound|END_ENTITY	Neural and paracrine regulation of gastrin release using rat antral mucosa in tissue culture -- the effect of carbachol , bombesin , and anti-somatostatin antibody on gastrin release .
2877911	0	carbachol	108,117	gastrin	35,42	carbachol	gastrin	MESH:D002217	25320(Tax:10116)	Chemical	Gene	bombesin|compound|START_ENTITY effect|nmod|bombesin regulation|dep|effect regulation|nmod|release release|compound|END_ENTITY	Neural and paracrine regulation of gastrin release using rat antral mucosa in tissue culture -- the effect of carbachol , bombesin , and anti-somatostatin antibody on gastrin release .
7380199	0	carbachol	11,20	gastrin	37,44	carbachol	gastrin	MESH:D002217	25320(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of carbachol and atropine on gastrin secretion and synthesis in rat antral organ culture .
7380199	4	carbachol	594,603	gastrin	520,527	carbachol	gastrin	MESH:D002217	25320(Tax:10116)	Chemical	Gene	X|amod|START_ENTITY concentration|nmod|X occurred|nmod|concentration occurred|nsubj|stimulation stimulation|nmod|synthesis synthesis|compound|END_ENTITY	Maximal stimulation of gastrin synthesis and release occurred at a concentration of 1 X 10 -LRB- -5 -RRB- M carbachol .
9073150	0	carbachol	10,19	gastrin	70,77	carbachol	gastrin	MESH:D002217	25320(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of carbachol on vascular and luminal release of immunoreactive gastrin from isolated perfused rat duodenum .
11358895	0	carbachol	14,23	interleukin_1beta	53,70	carbachol	interleukin 1beta	MESH:D002217	100008990(Tax:9986)	Chemical	Gene	secretion|amod|START_ENTITY secretion|nmod|END_ENTITY	Inhibition of carbachol stimulated_acid secretion by interleukin_1beta in rabbit parietal cells requires protein_kinase_C .
12091463	0	carbachol	73,82	p70S6_kinase	46,58	carbachol	p70S6 kinase	MESH:D002217	6198	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Effect of ethanol on protein_kinase_Czeta and p70S6_kinase activation by carbachol : a possible mechanism for ethanol-induced inhibition of glial cell proliferation .
7479339	0	carbachol	10,19	peptide_YY	38,48	carbachol	peptide YY	MESH:D002217	287730(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	Effect of carbachol on the release of peptide_YY from isolated vascularly and luminally perfused rat ileum .
1361226	0	carbachol	10,19	somatostatin	42,54	carbachol	somatostatin	MESH:D002217	24797(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of carbachol on luminal release of somatostatin from isolated perfused rat duodenum .
2879603	0	carbachol	11,20	somatostatin	49,61	carbachol	somatostatin	MESH:D002217	24797(Tax:10116)	Chemical	Gene	START_ENTITY|xcomp|influence influence|dobj|release release|nmod|END_ENTITY	Failure of carbachol to influence the release of somatostatin from slices of rat cerebral cortex .
12831623	0	carbachol	12,21	tumor_necrosis_factor-alpha	42,69	carbachol	tumor necrosis factor-alpha	MESH:D002217	24835(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|levels levels|nmod|END_ENTITY	-LSB- Effects of carbachol on plasma levels of tumor_necrosis_factor-alpha and interleukin-10 in rats during gut ischemia-reperfusion -RSB- .
24279603	0	carbamate	18,27	AChE	28,32	carbamate	AChE	CHEBI:28616	11423(Tax:10090)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	Meserine , a novel carbamate AChE inhibitor , ameliorates scopolamine-induced dementia and alleviates amyloidogenesis of APP/PS1 transgenic_mice .
17629476	0	carbamate	16,25	C-17	38,42	carbamate	C-17	CHEBI:28616	54360	Chemical	Gene	function|amod|START_ENTITY function|nmod|END_ENTITY	Steroids with a carbamate function at C-17 , a novel class of inhibitors for human and hamster steroid 5alpha-reductase .
16298297	0	carbamate	13,22	FAAH	39,43	carbamate	FAAH	CHEBI:28616	2166	Chemical	Gene	inactivation|amod|START_ENTITY inactivation|nmod|END_ENTITY	Mechanism of carbamate inactivation of FAAH : implications for the design of covalent inhibitors and in vivo functional probes for enzymes .
14644616	0	carbamate	21,30	acetylcholinesterase	106,126	carbamate	acetylcholinesterase	CHEBI:28616	83817(Tax:10116)	Chemical	Gene	pesticides|amod|START_ENTITY effects|nmod|pesticides END_ENTITY|nsubj|effects	Selective effects of carbamate pesticides on rat neuronal nicotinic acetylcholine receptors and rat brain acetylcholinesterase .
18965552	0	carbamate	61,70	acetylcholinesterase	85,105	carbamate	acetylcholinesterase	CHEBI:28616	83817(Tax:10116)	Chemical	Gene	inhibition|amod|START_ENTITY measure|dobj|inhibition method|acl|measure modification|nmod|method Comparison|nmod|modification Comparison|nmod|END_ENTITY	Comparison of a modification of the ellman method to measure carbamate inhibition of acetylcholinesterase in plasma , erythrocytes and brain tissues in sprague_dawley_rats using two analytical systems .
21114293	0	carbamate	45,54	acetylcholinesterase	98,118	carbamate	acetylcholinesterase	CHEBI:28616	43	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Synthesis and insecticidal activity of novel carbamate derivatives as potential dual-binding site acetylcholinesterase inhibitors .
22953799	0	carbamate	29,38	acetylcholinesterase	100,120	carbamate	acetylcholinesterase	CHEBI:28616	43	Chemical	Gene	pesticides|amod|START_ENTITY pesticides|nmod|biosensor biosensor|acl|based based|nmod|END_ENTITY	Electrochemical detection of carbamate pesticides in fruit and vegetables with a biosensor based on acetylcholinesterase immobilised on a composite_of_polyaniline-carbon_nanotubes .
2393978	0	carbamate	43,52	acetylcholinesterase	137,157	carbamate	acetylcholinesterase	CHEBI:28616	43	Chemical	Gene	resistance|amod|START_ENTITY estimating|dobj|resistance methods|acl|estimating evaluation|nmod|methods mosquitos|nsubj|evaluation mosquitos|nmod|assay assay|nmod|END_ENTITY	Field evaluation of methods for estimating carbamate resistance in Anopheles albimanus mosquitos from a microplate assay for insensitive acetylcholinesterase .
2494778	0	carbamate	120,129	acetylcholinesterase	68,88	carbamate	acetylcholinesterase	CHEBI:28616	83817(Tax:10116)	Chemical	Gene	intoxication|amod|START_ENTITY END_ENTITY|nmod|intoxication	The relationship between oxime-induced reactivation of carbamylated acetylcholinesterase and antidotal efficacy against carbamate intoxication .
2904861	0	carbamate	75,84	acetylcholinesterase	47,67	carbamate	acetylcholinesterase	CHEBI:28616	41625(Tax:7227)	Chemical	Gene	inhibitor|amod|START_ENTITY END_ENTITY|nmod|inhibitor	An investigation of the in vitro inhibition of acetylcholinesterase by the carbamate inhibitor eserine_sulphate in eserine resistant strains of Drosophila_melanogaster .
8264551	0	carbamate	35,44	acetylcholinesterase	98,118	carbamate	acetylcholinesterase	CHEBI:28616	43	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Monoclonal antibody AE-2 modulates carbamate and organophosphate inhibition of fetal_bovine_serum acetylcholinesterase .
9585096	0	carbamate	95,104	acetylcholinesterase	10,30	carbamate	acetylcholinesterase	CHEBI:28616	83817(Tax:10116)	Chemical	Gene	inhibitors|amod|START_ENTITY profile|nmod|inhibitors activity|dep|profile activity|compound|END_ENTITY	Rat brain acetylcholinesterase activity : developmental profile and maturational sensitivity to carbamate and organophosphorus inhibitors .
9890446	0	carbamate	82,91	acetylcholinesterase	54,74	carbamate	acetylcholinesterase	CHEBI:28616	105088569	Chemical	Gene	lannate|amod|START_ENTITY constants|nmod|lannate constants|nmod|inhibition inhibition|nmod|END_ENTITY	Kinetic constants for the inhibition of camel retinal acetylcholinesterase by the carbamate insecticide lannate .
10446376	1	carbamates	321,331	AChE	253,257	carbamates	AChE	MESH:D002219	11423(Tax:10090)	Chemical	Gene	involved|nmod|START_ENTITY involved|nmod|interaction interaction|nmod|acetylcholinesterase acetylcholinesterase|dep|END_ENTITY	In order to identify amino_acids involved in the interaction of acetylcholinesterase -LRB- AChE ; EC 3.1.1.7 -RRB- and butyrylcholinesterase -LRB- BChE ; EC 3.1.1.8 -RRB- with carbamates , the time course of inhibition of the recombinant mouse enzymes BChE wild-type -LRB- w.t. -RRB- , AChE w.t. and of 11 site-directed AChE mutants by Ro_02-0683 and bambuterol was studied .
18515163	0	carbamates	41,51	AChE	78,82	carbamates	AChE	MESH:D002219	43	Chemical	Gene	investigation|nmod|START_ENTITY investigation|appos|END_ENTITY	An investigation of structurally diverse carbamates for acetylcholinesterase -LRB- AChE -RRB- inhibition using 3D-QSAR analysis .
23026084	0	carbamates	57,67	AChE	78,82	carbamates	AChE	MESH:D002219	11423(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Lead optimization studies towards the discovery of novel carbamates as potent AChE inhibitors for the potential treatment of Alzheimer 's _ disease .
20684567	0	carbamates	6,16	acetylcholinesterase	34,54	carbamates	acetylcholinesterase	MESH:D002219	11423(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Novel carbamates as orally active acetylcholinesterase inhibitors found to improve scopolamine-induced cognition_impairment : pharmacophore-based virtual screening , synthesis , and pharmacology .
24344993	0	carbamates	95,105	acetylcholinesterase	61,81	carbamates	acetylcholinesterase	MESH:D002219	43	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubj|evidence evidence|nmod|process process|nmod|END_ENTITY	Computational evidence for the reactivation process of human acetylcholinesterase inhibited by carbamates .
4089884	0	carbamates	24,34	acetylcholinesterase	67,87	carbamates	acetylcholinesterase	MESH:D002219	11423(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY acetylcholine|nsubj|Effects acetylcholine|dobj|activity activity|amod|END_ENTITY	Effects of insecticidal carbamates on brain acetylcholine content , acetylcholinesterase activity and behavior in mice .
9073605	0	carbamates	52,62	neurotoxic_esterase	14,33	carbamates	neurotoxic esterase	MESH:D002219	10908	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of neurotoxic_esterase in vitro by novel carbamates .
9491835	0	carbamazepine	32,45	CYP1A2	13,19	carbamazepine	CYP1A2	MESH:D002220	1544	Chemical	Gene	activity|nmod|START_ENTITY activity|nummod|END_ENTITY	Induction of CYP1A2 activity by carbamazepine in children using the caffeine breath test .
18372180	0	carbamazepine	28,41	CYP3A4	45,51	carbamazepine	CYP3A4	MESH:D002220	1576	Chemical	Gene	mechanism|nmod|START_ENTITY mechanism|nmod|END_ENTITY	An epoxidation mechanism of carbamazepine by CYP3A4 .
19744012	0	carbamazepine	37,50	CYP3A5	10,16	carbamazepine	CYP3A5	MESH:D002220	1577	Chemical	Gene	concentrations|compound|START_ENTITY genotype|nmod|concentrations genotype|nsubj|Effect Effect|nmod|END_ENTITY	Effect of CYP3A5 * 3 genotype on serum carbamazepine concentrations at steady-state in Korean epileptic patients .
21441615	0	carbamazepine	11,24	IL-2	44,48	carbamazepine	IL-2	MESH:D002220	3558	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|amod|END_ENTITY	Effects of carbamazepine and metabolites on IL-2 , IL-5 , IL-6 , IL-10 and IFN-y secretion in epileptic patients : the influence of co-medication .
11733711	0	carbamazepine	146,159	P-glycoprotein	0,14	carbamazepine	P-glycoprotein	MESH:D002220	5243	Chemical	Gene	levels|nmod|START_ENTITY regulation|nmod|levels involved|nmod|regulation involved|nsubjpass|END_ENTITY	P-glycoprotein and multidrug_resistance-associated_protein are involved in the regulation of extracellular levels of the major antiepileptic drug carbamazepine in the brain .
16842400	0	carbamazepine	46,59	P-glycoprotein	13,27	carbamazepine	P-glycoprotein	MESH:D002220	5243	Chemical	Gene	lymphocytes|nmod|START_ENTITY END_ENTITY|nmod|lymphocytes	Induction of P-glycoprotein in lymphocytes by carbamazepine and rifampicin : the role of nuclear hormone response elements .
9630846	0	carbamazepine	20,33	P450	58,62	carbamazepine	P450	MESH:D002220	1555	Chemical	Gene	metabolites|amod|START_ENTITY metabolites|nmod|END_ENTITY	Covalent binding of carbamazepine reactive metabolites to P450 isoforms present in the skin .
7607122	0	carbamazepine	100,113	acetylcholinesterase	32,52	carbamazepine	acetylcholinesterase	MESH:D002220	83817(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY END_ENTITY|nmod|administration	Changes in learning and memory , acetylcholinesterase activity and monoamines in brain after chronic carbamazepine administration in rats .
3175459	0	carbamazepine	20,33	antidiuretic_hormone	56,76	carbamazepine	antidiuretic hormone	MESH:D002220	551	Chemical	Gene	START_ENTITY|nmod|action action|nmod|END_ENTITY	-LSB- Changes induced by carbamazepine in the action of ADH -LRB- antidiuretic_hormone -RRB- in neurologic patients -RSB- .
11488835	0	carbamazepine	73,86	desmogleins_1_and_3	29,48	carbamazepine	desmogleins 1 and 3	MESH:D002220	1828;1830	Chemical	Gene	administration|nmod|START_ENTITY END_ENTITY|nmod|administration	Increased antibody levels to desmogleins_1_and_3 after administration of carbamazepine .
19473818	0	carbamazepine	14,27	leptin	47,53	carbamazepine	leptin	MESH:D002220	3952	Chemical	Gene	treatment|amod|START_ENTITY effect|nmod|treatment effect|nmod|levels levels|compound|END_ENTITY	The effect of carbamazepine treatment on serum leptin levels .
2492224	0	carbamazepine	11,24	luteinizing_hormone-releasing_hormone	56,93	carbamazepine	luteinizing hormone-releasing hormone	MESH:D002220	2796	Chemical	Gene	Effects|nmod|START_ENTITY responsiveness|nsubj|Effects responsiveness|nmod|END_ENTITY	Effects of carbamazepine on pituitary responsiveness to luteinizing_hormone-releasing_hormone , thyrotropin-releasing_hormone , and metoclopramide in epileptic patients .
22772901	0	carbamazepine	21,34	signal_transducer_and_activator_of_transcription-3	100,150	carbamazepine	signal transducer and activator of transcription-3	MESH:D002220	20848(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Protective effect of carbamazepine on kainic_acid-induced neuronal cell death through activation of signal_transducer_and_activator_of_transcription-3 .
6433372	0	carbamazepine	15,28	thyrotropin-releasing_hormone	60,89	carbamazepine	thyrotropin-releasing hormone	MESH:D002220	7200	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of carbamazepine on the thyrotropin response to thyrotropin-releasing_hormone .
10917911	0	carbamoyl_phosphate	67,86	CPS-1	99,104	carbamoyl phosphate	CPS-1	MESH:D002221	1373	Chemical	Gene	START_ENTITY|dobj|activity activity|appos|END_ENTITY	Comparison of total body urea production potential with total body carbamoyl_phosphate synthetase -LRB- CPS-1 -RRB- activity in newborn piglets infused with alanine at 50 % of resting energy expenditure for 36 hours .
19272383	0	carbamoyl_phosphate	53,72	Y-box_binding_protein-1	0,23	carbamoyl phosphate	Y-box binding protein-1	MESH:D002221	22608(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Y-box_binding_protein-1 down-regulates expression of carbamoyl_phosphate synthetase-I by suppressing CCAAT enhancer-binding protein-alpha function in mice .
15326225	0	carbamoyl_phosphate	49,68	multifunctional_protein_CAD	96,123	carbamoyl phosphate	multifunctional protein CAD	MESH:D002221	790	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	The human Rad9 checkpoint protein stimulates the carbamoyl_phosphate synthetase activity of the multifunctional_protein_CAD .
9861696	0	carbamoylmethyl	73,88	C-4	98,101	carbamoylmethyl	C-4	null	720	Chemical	Gene	group|amod|START_ENTITY group|nmod|END_ENTITY	Chemoenzymatic synthesis of an N-acetylneuraminic_acid analogue having a carbamoylmethyl group at C-4 as an inhibitor of sialidase from influenza virus .
17310273	0	carbamoylphosphate	58,76	CPS1	91,95	carbamoylphosphate	CPS1	MESH:D002221	1373	Chemical	Gene	deficiency|amod|START_ENTITY deficiency|compound|END_ENTITY	Molecular and clinical analyses of Japanese patients with carbamoylphosphate synthetase 1 -LRB- CPS1 -RRB- deficiency .
7513319	0	carbamoylphosphate	175,193	alpha-fetoprotein	156,173	carbamoylphosphate	alpha-fetoprotein	MESH:D002221	174	Chemical	Gene	synthase|amod|START_ENTITY synthase|dep|END_ENTITY	Developmental changes in the expression of the liver-enriched transcription factors LF-B1 , C/EBP , DBP and LAP/LIP in relation to the expression of albumin , alpha-fetoprotein , carbamoylphosphate synthase and lactase mRNA .
7915141	0	carbamoylphosphate	76,94	glutamine_synthase	56,74	carbamoylphosphate	glutamine synthase	MESH:D002221	2752	Chemical	Gene	synthase|amod|START_ENTITY synthase|amod|END_ENTITY	Lobular patterns of expression and enzyme activities of glutamine_synthase , carbamoylphosphate synthase and glutamate dehydrogenase during postnatal development of the porcine liver .
8000501	0	carbamylcholine_chloride	11,35	gastrin	52,59	carbamylcholine chloride	gastrin	null	2520	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|compound|END_ENTITY	Effects of carbamylcholine_chloride on human antral gastrin mRNA levels .
9290206	0	carbamylphosphate	102,119	Cpa1p	89,94	carbamylphosphate	Cpa1p	MESH:D002221	854479(Tax:4932)	Chemical	Gene	synthetase|amod|START_ENTITY END_ENTITY|nmod|synthetase	In vivo mutational analysis of highly conserved amino_acid residues of the small subunit Cpa1p of the carbamylphosphate synthetase of Saccharomyces_cerevisiae .
19018025	0	carbapenem	11,21	OXA-23	82,88	carbapenem	OXA-23	CHEBI:46765	20472025	Chemical	Gene	resistance|compound|START_ENTITY resistance|dep|END_ENTITY	Increasing carbapenem resistance due to the clonal dissemination of oxacillinase -LRB- OXA-23 and OXA-58 -RRB- - producing Acinetobacter_baumannii : report from the Turkish SENTRY Program sites .
9449267	0	carbapenem	63,73	S-4661	49,55	carbapenem	S-4661	CHEBI:46765	1080859(Tax:198215)	Chemical	Gene	START_ENTITY|nmod|activities activities|nmod|END_ENTITY	In vitro and in vivo antibacterial activities of S-4661 , a new carbapenem .
10620349	0	carbaryl	29,37	CYP1A1	41,47	carbaryl	CYP1A1	MESH:D012721	24296(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inducer inducer|compound|END_ENTITY	Molecular characteristics of carbaryl , a CYP1A1 gene inducer .
9858662	0	carbaryl	11,19	CYP1A1/2	51,59	carbaryl	CYP1A1/2	MESH:D012721	24296(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of carbaryl and naphthalene on rat hepatic CYP1A1/2 : potential binding to Ah_receptor and 4S_benzo -LRB- a -RRB- pyrene-binding protein .
11226373	0	carbaryl	88,96	cytochrome_P450_1A1	13,32	carbaryl	cytochrome P450 1A1	MESH:D012721	1543	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|expression expression|amod|END_ENTITY	Induction of cytochrome_P450_1A1 gene expression , oxidative stress , and genotoxicity by carbaryl and thiabendazole in transfected human HepG2 and lymphoblastoid cells .
11910494	1	carbazole	74,83	CDH-7	32,37	carbazole	CDH-7	MESH:C041514	1005	Chemical	Gene	cells|nmod|START_ENTITY cells|compound|END_ENTITY	CDH-7 cells for continuous degradation of carbazole in the presence of MgCl2 .
18225986	0	carbenoxolone	57,70	11beta-HSD1	34,45	carbenoxolone	11beta-HSD1	MESH:D002229	15483(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Sub-chronic administration of the 11beta-HSD1 inhibitor , carbenoxolone , improves glucose_tolerance_and_insulin_sensitivity in mice with diet-induced obesity .
17937860	0	carbenoxolone	11,24	Fos	42,45	carbenoxolone	Fos	MESH:D002229	314322(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of carbenoxolone on expression of Fos , NMDAR2 and GFAP in the hippocampus of pentylenetetrazo-kindled epileptic rats -RSB- .
6157471	0	carbenoxolone	10,23	gastric_mucin	42,55	carbenoxolone	gastric mucin	MESH:D002229	4586	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of carbenoxolone and cimetidine on gastric_mucin .
21962914	0	carbetocin	40,50	oxytocin	15,23	carbetocin	oxytocin	MESH:C020731	5020	Chemical	Gene	effects|acl|START_ENTITY effects|nmod|END_ENTITY	The effects of oxytocin and its analog , carbetocin , on genetic_deficits in sensorimotor gating .
1101099	0	carbidopa	44,53	dopa_decarboxylase	14,32	carbidopa	dopa decarboxylase	MESH:D002230	1644	Chemical	Gene	Comparison|appos|START_ENTITY Comparison|nmod|inhibitor inhibitor|amod|END_ENTITY	Comparison of dopa_decarboxylase inhibitor -LRB- carbidopa -RRB- combined with levodopa and levodopa alone in Parkinson 's _ disease .
834247	0	carbidopa	64,73	dopa_decarboxylase	102,120	carbidopa	dopa decarboxylase	MESH:D002230	1644	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Suppression of noradrenaline synthesis in sympathetic nerves by carbidopa , an inhibitor of peripheral dopa_decarboxylase .
3159521	0	carbimazole	56,67	interleukin-2	31,44	carbimazole	interleukin-2	MESH:D002231	3558	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Inhibition of the receptor for interleukin-2 induced by carbimazole : relevance for the therapy of autoimmune_thyroid_disease .
2129783	0	carbimazole	14,25	interleukin_2	37,50	carbimazole	interleukin 2	MESH:D002231	3558	Chemical	Gene	therapy|amod|START_ENTITY effect|nmod|therapy effect|nmod|END_ENTITY	The effect of carbimazole therapy on interleukin_2 , interleukin_2 receptors and free radicals .
15033371	0	carbocisteine	11,24	Muc5ac	104,110	carbocisteine	Muc5ac	null	682837(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of carbocisteine on altered activities of glycosidase_and_glycosyltransferase and expression of Muc5ac in SO2-exposed rats .
15033371	0	carbocisteine	11,24	glycosidase_and_glycosyltransferase	50,85	carbocisteine	glycosidase and glycosyltransferase	null	316091(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activities activities|nmod|END_ENTITY	Effects of carbocisteine on altered activities of glycosidase_and_glycosyltransferase and expression of Muc5ac in SO2-exposed rats .
16387297	0	carbocisteine	11,24	tumor_necrosis_factor-alpha	103,130	carbocisteine	tumor necrosis factor-alpha	null	7124	Chemical	Gene	Effects|nmod|START_ENTITY stimulated|nsubj|Effects stimulated|nmod|END_ENTITY	Effects of carbocisteine on sialyl-Lewis x expression in an airway carcinoma cell line stimulated with tumor_necrosis_factor-alpha .
479609	0	carbodiimide	60,72	ovalbumin	11,20	carbodiimide	ovalbumin	CHEBI:53091	282665(Tax:10090)	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of ovalbumin to mouse spleen cells with and without carbodiimide .
2792382	0	carbodiimides	48,61	thrombin	22,30	carbodiimides	thrombin	MESH:D002234	2147	Chemical	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of human thrombin by water-soluble carbodiimides .
1375034	0	carbohydrate	30,42	ABO	22,25	carbohydrate	ABO	CHEBI:16646	28	Chemical	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Altered expression of ABO -LRB- H -RRB- carbohydrate antigens is seen in pleomorphic_adenomas .
7672355	0	carbohydrate	21,33	Amylin	0,6	carbohydrate	Amylin	CHEBI:16646	3375	Chemical	Gene	metabolism|amod|START_ENTITY regulation|nmod|metabolism regulation|compound|END_ENTITY	Amylin regulation of carbohydrate metabolism .
11676606	0	carbohydrate	17,29	CD154	121,126	carbohydrate	CD154	CHEBI:16646	959	Chemical	Gene	structures|amod|START_ENTITY structures|nmod|END_ENTITY	Determination of carbohydrate structures N-linked to soluble CD154 and characterization of the interactions of CD40 with CD154 expressed in Pichia_pastoris and Chinese_hamster ovary cells .
10900005	5	carbohydrate	940,952	CD26	963,967	carbohydrate	CD26	CHEBI:16646	1803	Chemical	Gene	moiety|amod|START_ENTITY moiety|nmod|END_ENTITY	In the present study , we have identified the mannose_6-phosphate / insulin-like growth factor II receptor -LRB- M6P/IGFIIR -RRB- as a binding protein for CD26 and that mannose_6-phosphate -LRB- M6P -RRB- residues in the carbohydrate moiety of CD26 are critical for this binding .
23400223	0	carbohydrate	69,81	CD43	92,96	carbohydrate	CD43	CHEBI:16646	6693	Chemical	Gene	chains|amod|START_ENTITY chains|nmod|END_ENTITY	Macrophage recognition of cells with elevated calcium is mediated by carbohydrate chains of CD43 .
15288185	0	carbohydrate	30,42	CD52	80,84	carbohydrate	CD52	CHEBI:16646	1043	Chemical	Gene	presence|nmod|START_ENTITY presence|nmod|END_ENTITY	Possible presence of O-linked carbohydrate in the human male reproductive tract CD52 .
2445351	1	carbohydrate	279,291	CEA	275,278	carbohydrate	CEA	CHEBI:16646	1084	Chemical	Gene	chains|compound|START_ENTITY chains|compound|END_ENTITY	The majority of topographic antigenic determinants of the carcinoembryonic_antigen -LRB- CEA -RRB- representing a glycoprotein were shown to contain sugar residues of the CEA carbohydrate chains .
11139648	0	carbohydrate	21,33	CHST6	59,64	carbohydrate	CHST6	CHEBI:16646	4166	Chemical	Gene	Mutations|nmod|START_ENTITY sulfotransferase|nsubj|Mutations sulfotransferase|ccomp|cause cause|nsubj|gene gene|appos|END_ENTITY	Mutations in corneal carbohydrate sulfotransferase 6 gene -LRB- CHST6 -RRB- cause macular corneal_dystrophy in Iceland .
11818380	0	carbohydrate	41,53	CHST6	77,82	carbohydrate	CHST6	CHEBI:16646	4166	Chemical	Gene	sulfotransferase|amod|START_ENTITY gene|amod|sulfotransferase gene|appos|END_ENTITY	Identification of novel mutations in the carbohydrate sulfotransferase gene -LRB- CHST6 -RRB- causing macular corneal_dystrophy .
12824236	0	carbohydrate	28,40	CHST6	66,71	carbohydrate	CHST6	CHEBI:16646	4166	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Truncating mutations in the carbohydrate sulfotransferase 6 gene -LRB- CHST6 -RRB- result in macular_corneal_dystrophy .
16550483	0	carbohydrate	4,16	DEFB126	30,37	carbohydrate	DEFB126	CHEBI:16646	102132878	Chemical	Gene	structure|amod|START_ENTITY structure|nmod|END_ENTITY	The carbohydrate structure of DEFB126 , the major component of the cynomolgus_Macaque sperm plasma membrane glycocalyx .
12057664	0	carbohydrate	161,173	E-selectin	196,206	carbohydrate	E-selectin	CHEBI:16646	6401	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Effect of protonation of the N-acetyl_neuraminic_acid residue of sialyl_Lewis -LRB- X -RRB- : a molecular orbital study with insights into its binding properties toward the carbohydrate recognition domain of E-selectin .
19948406	0	carbohydrate	12,24	E-selectin	47,57	carbohydrate	E-selectin	CHEBI:16646	6401	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Probing the carbohydrate recognition domain of E-selectin : the importance of the acid orientation in sLex mimetics .
7681016	0	carbohydrate	14,26	E-selectin	55,65	carbohydrate	E-selectin	CHEBI:16646	6401	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Modelling the carbohydrate recognition domain of human E-selectin .
9538143	0	carbohydrate	88,100	E-selectin	113,123	carbohydrate	E-selectin	CHEBI:16646	6401	Chemical	Gene	ligands|amod|START_ENTITY ligands|nmod|END_ENTITY	Gene expression of fucosyl - and sialyl-transferases which synthesize sialyl Lewisx , the carbohydrate ligands for E-selectin , in human breast_cancer .
6166621	10	carbohydrate	1195,1207	GP-2	1288,1292	carbohydrate	GP-2	CHEBI:16646	171459(Tax:10116)	Chemical	Gene	moiety|amod|START_ENTITY involved|nsubjpass|moiety involved|advcl|directed directed|nsubjpass|END_ENTITY	We found that the carbohydrate moiety of GP-2 was involved in the antigenic determinant for R x ZGM , while R x GP-2 was most likely directed against GP-2 polypeptide backbone .
1639023	0	carbohydrate	99,111	Growth_hormone	0,14	carbohydrate	Growth hormone	CHEBI:16646	81668(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY actions|nmod|metabolism correlation|nmod|actions calcium|dep|correlation intracellular|dobj|calcium intracellular|nsubj|increases increases|amod|END_ENTITY	Growth_hormone increases intracellular free calcium in rat adipocytes : correlation with actions on carbohydrate metabolism .
8300047	0	carbohydrate	26,38	Growth_hormone	0,14	carbohydrate	Growth hormone	CHEBI:16646	2688	Chemical	Gene	metabolism|compound|START_ENTITY effects|nmod|metabolism effects|amod|END_ENTITY	Growth_hormone effects on carbohydrate and lipid metabolism in childhood .
8474315	0	carbohydrate	59,71	Growth_hormone	0,14	carbohydrate	Growth hormone	CHEBI:16646	2688	Chemical	Gene	oxidation|amod|START_ENTITY decreased|dobj|oxidation decreased|nsubj|treatment treatment|amod|END_ENTITY	Growth_hormone treatment after abdominal surgery decreased carbohydrate oxidation and increased fat oxidation in patients with total parenteral nutrition .
10082676	0	carbohydrate	109,121	HNK-1	103,108	carbohydrate	HNK-1	CHEBI:16646	117108(Tax:10116)	Chemical	Gene	epitope|compound|START_ENTITY epitope|compound|END_ENTITY	Molecular cloning and expression of a second glucuronyltransferase involved in the biosynthesis of the HNK-1 carbohydrate epitope .
10783264	0	carbohydrate	101,113	HNK-1	95,100	carbohydrate	HNK-1	CHEBI:16646	27087	Chemical	Gene	epitope|compound|START_ENTITY epitope|compound|END_ENTITY	Cloning and chromosomal mapping of human glucuronyltransferase involved in biosynthesis of the HNK-1 carbohydrate epitope .
11037910	0	carbohydrate	44,56	HNK-1	38,43	carbohydrate	HNK-1	CHEBI:16646	27087	Chemical	Gene	epitope|compound|START_ENTITY epitope|compound|END_ENTITY	Search for autoantibodies against the HNK-1 carbohydrate epitope in the human eye in intermediate uveitis .
11044619	0	carbohydrate	73,85	HNK-1	67,72	carbohydrate	HNK-1	CHEBI:16646	117108(Tax:10116)	Chemical	Gene	epitope|compound|START_ENTITY epitope|compound|END_ENTITY	Differential expression of two glucuronyltransferases synthesizing HNK-1 carbohydrate epitope in the sublineages of the rat myogenic progenitors .
11875281	0	carbohydrate	44,56	HNK-1	38,43	carbohydrate	HNK-1	CHEBI:16646	76898(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|localization localization|nmod|END_ENTITY	Immunocytological localization of the HNK-1 carbohydrate in murine cerebellum , hippocampus and spinal cord using monoclonal antibodies with different epitope specificities .
12032138	0	carbohydrate	42,54	HNK-1	63,68	carbohydrate	HNK-1	CHEBI:16646	76898(Tax:10090)	Chemical	Gene	exhibit|compound|START_ENTITY exhibit|compound|END_ENTITY	Mice deficient in nervous system-specific carbohydrate epitope HNK-1 exhibit impaired synaptic plasticity and spatial learning .
12383500	0	carbohydrate	135,147	HNK-1	129,134	carbohydrate	HNK-1	CHEBI:16646	76898(Tax:10090)	Chemical	Gene	epitope|compound|START_ENTITY epitope|compound|END_ENTITY	cDNA cloning , genomic structure and chromosomal mapping of the mouse glucuronyltransferase-S involved in the biosynthesis of the HNK-1 carbohydrate epitope .
12892407	0	carbohydrate	15,27	HNK-1	9,14	carbohydrate	HNK-1	CHEBI:16646	117108(Tax:10116)	Chemical	Gene	epitope|compound|START_ENTITY epitope|compound|END_ENTITY	Roles of HNK-1 carbohydrate epitope and its synthetic glucuronyltransferase genes on migration of rat neural crest cells .
1385405	0	carbohydrate	101,113	HNK-1	95,100	carbohydrate	HNK-1	CHEBI:16646	117108(Tax:10116)	Chemical	Gene	epitope|compound|START_ENTITY epitope|compound|END_ENTITY	A novel glucuronyltransferase in nervous system presumably associated with the biosynthesis of HNK-1 carbohydrate epitope on glycoproteins .
14993226	0	carbohydrate	141,153	HNK-1	162,167	carbohydrate	HNK-1	CHEBI:16646	27087	Chemical	Gene	epitope|amod|START_ENTITY biosynthesis|nmod|epitope critical|nmod|biosynthesis END_ENTITY|amod|critical	Structural basis for acceptor substrate recognition of a human glucuronyltransferase , GlcAT-P , an enzyme critical in the biosynthesis of the carbohydrate epitope HNK-1 .
15341523	0	carbohydrate	120,132	HNK-1	113,118	carbohydrate	HNK-1	CHEBI:16646	76898(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|expression expression|appos|END_ENTITY	Developmental expression of receptor_for_advanced_glycation_end_products -LRB- RAGE -RRB- , amphoterin and sulfoglucuronyl -LRB- HNK-1 -RRB- carbohydrate in mouse cerebellum and their role in neurite outgrowth and cell migration .
16460731	0	carbohydrate	36,48	HNK-1	30,35	carbohydrate	HNK-1	CHEBI:16646	76898(Tax:10090)	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	BDNF/TrkB signaling regulates HNK-1 carbohydrate expression in regenerating motor nerves and promotes functional recovery after peripheral nerve repair .
16897771	0	carbohydrate	103,115	HNK-1	97,102	carbohydrate	HNK-1	CHEBI:16646	27087	Chemical	Gene	epitope|compound|START_ENTITY epitope|compound|END_ENTITY	Crystal structure of GlcAT-S , a human glucuronyltransferase , involved in the biosynthesis of the HNK-1 carbohydrate epitope .
1713613	0	carbohydrate	32,44	HNK-1	23,28	carbohydrate	HNK-1	CHEBI:16646	27087	Chemical	Gene	epitope|amod|START_ENTITY L2|amod|epitope expression|dep|L2 expression|nmod|END_ENTITY	High expression of the HNK-1 / L2 carbohydrate epitope in the major glycoproteins of shark myelin .
1714552	0	carbohydrate	64,76	HNK-1	145,150	carbohydrate	HNK-1	CHEBI:16646	27087	Chemical	Gene	epitopes|amod|START_ENTITY cerebellum|nmod|epitopes Expression|nmod|cerebellum revealed|nsubj|Expression revealed|nmod|Elec-39 Elec-39|appos|antibody antibody|acl|related related|nmod|END_ENTITY	Expression and localization in the developing cerebellum of the carbohydrate epitopes revealed by Elec-39 , an IgM monoclonal antibody related to HNK-1 .
1717490	0	carbohydrate	60,72	HNK-1	54,59	carbohydrate	HNK-1	CHEBI:16646	117108(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Developmentally and spatially regulated expression of HNK-1 carbohydrate antigen on a novel phosphatidylinositol-anchored glycoprotein in rat brain .
18024472	0	carbohydrate	37,49	HNK-1	31,36	carbohydrate	HNK-1	CHEBI:16646	27087	Chemical	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression and function of the HNK-1 carbohydrate .
18077549	0	carbohydrate	71,83	HNK-1	106,111	carbohydrate	HNK-1	CHEBI:16646	76898(Tax:10090)	Chemical	Gene	moiety|amod|START_ENTITY moiety|nmod|END_ENTITY	Glucuronylation in Escherichia_coli for the bacterial synthesis of the carbohydrate moiety of nonsulfated HNK-1 .
19958024	0	carbohydrate	77,89	HNK-1	71,76	carbohydrate	HNK-1	CHEBI:16646	27087	Chemical	Gene	antigen|compound|START_ENTITY antigen|compound|END_ENTITY	Why structurally different cyclic peptides can be glycomimetics of the HNK-1 carbohydrate antigen .
22669261	0	carbohydrate	76,88	HNK-1	69,74	carbohydrate	HNK-1	CHEBI:16646	27087	Chemical	Gene	START_ENTITY|nsubj|expression expression|appos|END_ENTITY	Regulated expression and neural functions of human natural killer-1 -LRB- HNK-1 -RRB- carbohydrate .
9368071	0	carbohydrate	99,111	HNK-1	93,98	carbohydrate	HNK-1	CHEBI:16646	117108(Tax:10116)	Chemical	Gene	epitope|compound|START_ENTITY epitope|compound|END_ENTITY	Expression cloning of a cDNA encoding a sulfotransferase involved in the biosynthesis of the HNK-1 carbohydrate epitope .
9800516	0	carbohydrate	97,109	HNK-1	91,96	carbohydrate	HNK-1	CHEBI:16646	76898(Tax:10090)	Chemical	Gene	epitope|compound|START_ENTITY epitope|compound|END_ENTITY	-LSB- Molecular biological approach to functions of telencephalin , a cell adhesion molecule and HNK-1 carbohydrate epitope , which is commonly expressed on cell adhesion molecules in the nervous system -RSB- .
9100217	0	carbohydrate	38,50	IGF-1	88,93	carbohydrate	IGF-1	CHEBI:16646	24482(Tax:10116)	Chemical	Gene	intake|amod|START_ENTITY intake|nmod|END_ENTITY	Evaluation of differential effects of carbohydrate and fat intake on weight_gain , serum IGF-1 and erythrocyte Na + K+ATP ase activity in suboptimal nutrition in rats .
24755714	0	carbohydrate	49,61	IGFI_receptor	94,107	carbohydrate	IGFI receptor	CHEBI:16646	3480	Chemical	Gene	intake|amod|START_ENTITY intake|nmod|END_ENTITY	Risk of breast_cancer recurrence associated with carbohydrate intake and tissue expression of IGFI_receptor .
1132602	1	carbohydrate	64,76	Insulin	38,45	carbohydrate	Insulin	CHEBI:16646	3630	Chemical	Gene	responses|nmod|START_ENTITY responses|compound|END_ENTITY	Insulin responses to oral carbohydrate over a wide spectrum of glucose tolerance .
15474880	0	carbohydrate	173,185	Insulin	0,7	carbohydrate	Insulin	CHEBI:16646	3630	Chemical	Gene	load|compound|START_ENTITY polycystic_ovary_syndrome|nmod|load polycystic_ovary_syndrome|nsubj|secretion secretion|compound|END_ENTITY	Insulin secretion in women who have polycystic_ovary_syndrome and carry the Gly972Arg variant of insulin_receptor_substrate-1 in response to a high-glycemic or low-glycemic carbohydrate load .
1832873	0	carbohydrate	20,32	Insulin	0,7	carbohydrate	Insulin	CHEBI:16646	3630	Chemical	Gene	metabolism|amod|START_ENTITY resistance|appos|metabolism resistance|compound|END_ENTITY	Insulin resistance , carbohydrate metabolism , and hypertension .
24007934	0	carbohydrate	49,61	Insulin	0,7	carbohydrate	Insulin	CHEBI:16646	3630	Chemical	Gene	loading|amod|START_ENTITY function|nmod|loading function|nsubj|sensitivity sensitivity|compound|END_ENTITY	Insulin sensitivity and beta-cell function after carbohydrate oral loading in hip replacement surgery : a double-blind , randomised controlled clinical trial .
24477048	0	carbohydrate	84,96	Insulin	0,7	carbohydrate	Insulin	CHEBI:16646	397415(Tax:9823)	Chemical	Gene	metabolisms|amod|START_ENTITY re-establishes|nmod|metabolisms re-establishes|nsubj|treatment treatment|compound|END_ENTITY	Insulin treatment of streptozotocin-induced diabetes re-establishes the patterns in carbohydrate , fat and amino_acid metabolisms in growing pigs .
2505753	0	carbohydrate	30,42	Insulin	0,7	carbohydrate	Insulin	CHEBI:16646	3630	Chemical	Gene	metabolism|amod|START_ENTITY steps|nmod|metabolism controls|dobj|steps controls|nsubj|END_ENTITY	Insulin controls key steps of carbohydrate metabolism in cultured HT29 colon_cancer cells .
3053750	0	carbohydrate	81,93	Insulin	0,7	carbohydrate	Insulin	CHEBI:16646	3630	Chemical	Gene	importance|nmod|START_ENTITY resistance|dep|importance resistance|amod|END_ENTITY	Insulin resistance and beta-cell dysfunction in aging : the importance of dietary carbohydrate .
46445	0	carbohydrate	26,38	Insulin	0,7	carbohydrate	Insulin	CHEBI:16646	3630	Chemical	Gene	responses|nmod|START_ENTITY responses|compound|END_ENTITY	Insulin responses to oral carbohydrate in true prediabetics and matched controls .
5350107	0	carbohydrate	20,32	Insulin	0,7	carbohydrate	Insulin	CHEBI:16646	3630	Chemical	Gene	START_ENTITY|nsubj|response response|compound|END_ENTITY	Insulin response to carbohydrate ingestion after gastric surgery with special reference to hypoglycaemia .
6337175	0	carbohydrate	60,72	Insulin	0,7	carbohydrate	Insulin	CHEBI:16646	3630	Chemical	Gene	restriction|amod|START_ENTITY treated|nmod|restriction treated|nsubj|END_ENTITY	Insulin binding to monocytes in obese patients treated with carbohydrate restriction and changes in physical activity .
6364720	0	carbohydrate	75,87	Insulin	0,7	carbohydrate	Insulin	CHEBI:16646	3630	Chemical	Gene	homeostasis|amod|START_ENTITY effect|nmod|homeostasis END_ENTITY|dep|effect	Insulin injected into CNS structures or into the carotid artery : effect on carbohydrate homeostasis of the intact animal .
6807693	0	carbohydrate	43,55	Insulin	0,7	carbohydrate	Insulin	CHEBI:16646	3630	Chemical	Gene	diet|amod|START_ENTITY increased|nmod|diet increased|nsubj|binding binding|compound|END_ENTITY	Insulin receptor binding increased by high carbohydrate low fat diet in non-insulin-dependent diabetics .
97078	0	carbohydrate	19,31	Insulin	0,7	carbohydrate	Insulin	CHEBI:16646	3630	Chemical	Gene	tolerance|amod|START_ENTITY secretion|appos|tolerance secretion|compound|END_ENTITY	Insulin secretion , carbohydrate tolerance , fat metabolism and body weight in maturity onset diabetics requiring various methods of therapy .
12163000	0	carbohydrate	76,88	Insulin-like_growth_factor_binding_protein-4	0,44	carbohydrate	Insulin-like growth factor binding protein-4	CHEBI:16646	3487	Chemical	Gene	dependent|nmod|START_ENTITY dependent|nsubj|expression expression|amod|END_ENTITY	Insulin-like_growth_factor_binding_protein-4 expression is dependent on the carbohydrate in the media in HT-29 cells .
2119296	0	carbohydrate	17,29	Insulin_receptor	0,16	carbohydrate	Insulin receptor	CHEBI:16646	3643	Chemical	Gene	units|compound|START_ENTITY units|amod|END_ENTITY	Insulin_receptor carbohydrate units contain poly-N-acetyllactosamine chains .
6382903	0	carbohydrate	94,106	Insulin_receptor	1,17	carbohydrate	Insulin receptor	CHEBI:16646	3643	Chemical	Gene	-RSB-|amod|START_ENTITY development|nmod|-RSB- significance|nmod|development END_ENTITY|dep|significance	-LSB- Insulin_receptor and postreceptor disorders : significance for the development and therapy of carbohydrate metabolic_disorders -RSB- .
10873577	0	carbohydrate	159,171	K-ras	108,113	carbohydrate	K-ras	CHEBI:16646	3845	Chemical	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	CEA is the major PHA-L-reactive glycoprotein in colon_carcinoma cell lines and tumors : relationship between K-ras activation and beta1-6 branching of N-linked carbohydrate on CEA .
18061677	0	carbohydrate	4,16	Langerin	39,47	carbohydrate	Langerin	CHEBI:16646	50489	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	The carbohydrate recognition domain of Langerin reveals high structural similarity with the one of DC-SIGN but an additional , calcium-independent sugar-binding site .
10567012	0	carbohydrate	19,31	Leptin	0,6	carbohydrate	Leptin	CHEBI:16646	3952	Chemical	Gene	meal|amod|START_ENTITY response|nmod|meal response|compound|END_ENTITY	Leptin response to carbohydrate or fat meal and association with subsequent satiety and energy intake .
17582096	0	carbohydrate	20,32	MUC15	54,59	carbohydrate	MUC15	CHEBI:16646	337919(Tax:9913)	Chemical	Gene	structures|amod|START_ENTITY Characterization|nmod|structures Characterization|nmod|END_ENTITY	Characterization of carbohydrate structures of bovine MUC15 and distribution of the mucin in bovine milk .
19587101	0	carbohydrate	29,41	NARA5	65,70	carbohydrate	NARA5	CHEBI:16646	828871(Tax:3702)	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	A phosphofructokinase B-type carbohydrate kinase family protein , NARA5 , for massive expressions of plastid-encoded photosynthetic genes in Arabidopsis .
1551493	0	carbohydrate	14,26	S14	48,51	carbohydrate	S14	CHEBI:16646	25357(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY regulates|nsubj|metabolism regulates|dobj|transcription transcription|nummod|END_ENTITY	Cell-specific carbohydrate metabolism regulates S14 gene transcription .
1618827	0	carbohydrate	18,30	S14	59,62	carbohydrate	S14	CHEBI:16646	25357(Tax:10116)	Chemical	Gene	element|amod|START_ENTITY Definition|nmod|element Definition|nmod|gene gene|compound|END_ENTITY	Definition of the carbohydrate response element of the rat S14 gene .
18556348	0	carbohydrate	111,123	S14	35,38	carbohydrate	S14	CHEBI:16646	21835(Tax:10090)	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|nmod|S14-related S14-related|appos|END_ENTITY	Hepatic expression of the SPOT_14 -LRB- S14 -RRB- paralog S14-related -LRB- Mid1 interacting protein -RRB- is regulated by dietary carbohydrate .
2856412	0	carbohydrate	23,35	S14	105,108	carbohydrate	S14	CHEBI:16646	25357(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Interaction of dietary carbohydrate and glucagon in regulation of rat hepatic messenger ribonucleic acid S14 expression : role of circadian factors and 3 ' ,5 ' - cyclic_adenosine_monophosphate .
8132677	0	carbohydrate	18,30	S14	59,62	carbohydrate	S14	CHEBI:16646	25357(Tax:10116)	Chemical	Gene	element|amod|START_ENTITY Definition|nmod|element Definition|nmod|gene gene|compound|END_ENTITY	Definition of the carbohydrate response element of the rat S14 gene .
8912809	0	carbohydrate	20,32	S14	57,60	carbohydrate	S14	CHEBI:16646	25357(Tax:10116)	Chemical	Gene	element|amod|START_ENTITY Identification|nmod|element Identification|nmod|gene gene|compound|END_ENTITY	Identification of a carbohydrate response element in rat S14 gene .
24434373	0	carbohydrate	18,30	SIGNR1	45,51	carbohydrate	SIGNR1	CHEBI:16646	69165(Tax:10090)	Chemical	Gene	preference|amod|START_ENTITY preference|nmod|END_ENTITY	Comparison of the carbohydrate preference of SIGNR1 as a phagocytic receptor with the preference as an adhesion molecule .
16764994	0	carbohydrate	13,25	SIT4	44,48	carbohydrate	SIT4	CHEBI:16646	851513(Tax:4932)	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|nmod|END_ENTITY	Deviation of carbohydrate metabolism by the SIT4 phosphatase in Saccharomyces_cerevisiae .
1334078	0	carbohydrate	104,116	SP-A	127,131	carbohydrate	SP-A	CHEBI:16646	653509	Chemical	Gene	moiety|amod|START_ENTITY moiety|nmod|END_ENTITY	Binding of surfactant protein A -LRB- SP-A -RRB- to herpes_simplex_virus_type_1-infected cells is mediated by the carbohydrate moiety of SP-A .
9789003	0	carbohydrate	31,43	SREBP_cleavage-activating_protein	64,97	carbohydrate	SREBP cleavage-activating protein	CHEBI:16646	100689048	Chemical	Gene	chains|amod|START_ENTITY chains|nmod|END_ENTITY	Sterols regulate processing of carbohydrate chains of wild-type SREBP_cleavage-activating_protein -LRB- SCAP -RRB- , but not sterol-resistant mutants Y298C or D443N .
17228091	0	carbohydrate	41,53	adiponectin	8,19	carbohydrate	adiponectin	CHEBI:16646	9370	Chemical	Gene	metabolism|compound|START_ENTITY regulation|nmod|metabolism Role|nmod|regulation Role|nmod|END_ENTITY	Role of adiponectin in the regulation of carbohydrate and lipid metabolism .
17485917	0	carbohydrate	105,117	alpha-glucosidase	68,85	carbohydrate	alpha-glucosidase	CHEBI:16646	69983(Tax:10090)	Chemical	Gene	inhibitors|nmod|START_ENTITY inhibitors|amod|END_ENTITY	Comparison of efficacies of a dipeptidyl_peptidase_IV inhibitor and alpha-glucosidase inhibitors in oral carbohydrate and meal tolerance tests and the effects of their combination in mice .
12218066	0	carbohydrate	16,28	alpha_2-macroglobulin	79,100	carbohydrate	alpha 2-macroglobulin	CHEBI:16646	2	Chemical	Gene	sites|amod|START_ENTITY Localization|nmod|sites limulus|nsubj|Localization limulus|xcomp|END_ENTITY	Localization of carbohydrate attachment sites and disulfide bridges in limulus alpha_2-macroglobulin .
2421999	0	carbohydrate	24,36	alpha_2-macroglobulin	50,71	carbohydrate	alpha 2-macroglobulin	CHEBI:16646	2	Chemical	Gene	structure|amod|START_ENTITY structure|nmod|END_ENTITY	-LSB- Characteristics of the carbohydrate structure of alpha_2-macroglobulin in stomach_cancer -RSB- .
2582343	0	carbohydrate	18,30	alpha_2-macroglobulin	46,67	carbohydrate	alpha 2-macroglobulin	CHEBI:16646	2	Chemical	Gene	composition|amod|START_ENTITY composition|nmod|END_ENTITY	Comparison of the carbohydrate composition of alpha_2-macroglobulin from patients with cystic_fibrosis and normal controls .
9442926	0	carbohydrate	19,31	alpha_2-macroglobulin	42,63	carbohydrate	alpha 2-macroglobulin	CHEBI:16646	2	Chemical	Gene	moiety|amod|START_ENTITY moiety|nmod|END_ENTITY	An increase in the carbohydrate moiety of alpha_2-macroglobulin is associated with systemic_lupus_erythematosus -LRB- SLE -RRB- .
1628773	0	carbohydrate	30,42	amylin	20,26	carbohydrate	amylin	CHEBI:16646	3375	Chemical	Gene	metabolism|amod|START_ENTITY END_ENTITY|nmod|metabolism	In vitro effects of amylin on carbohydrate metabolism in liver cells .
1936264	0	carbohydrate	44,56	amylin	34,40	carbohydrate	amylin	CHEBI:16646	24476(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY actions|nmod|metabolism actions|nmod|END_ENTITY	8-37h-CGRP antagonizes actions of amylin on carbohydrate metabolism in vitro and in vivo .
2198023	0	carbohydrate	25,37	amylin	15,21	carbohydrate	amylin	CHEBI:16646	3375	Chemical	Gene	metabolism|amod|START_ENTITY effects|nmod|metabolism effects|nmod|END_ENTITY	The effects of amylin on carbohydrate metabolism in skeletal muscle in vitro and in vivo .
2930480	0	carbohydrate	27,39	angiotensin_II	123,137	carbohydrate	angiotensin II	CHEBI:16646	24179(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|receptors receptors|amod|END_ENTITY	-LSB- Leu -RSB- enkephalin stimulates carbohydrate metabolism in isolated hepatocytes and kidney tubule fragments by interaction with angiotensin_II receptors .
11087713	0	carbohydrate	8,20	annexin_V	41,50	carbohydrate	annexin V	CHEBI:16646	308	Chemical	Gene	START_ENTITY|dobj|activity activity|nmod|END_ENTITY	A novel carbohydrate binding activity of annexin_V toward a bisecting N-acetylglucosamine .
9101419	0	carbohydrate	24,36	apolipoprotein_H	51,67	carbohydrate	apolipoprotein H	CHEBI:16646	350	Chemical	Gene	structures|amod|START_ENTITY structures|nmod|END_ENTITY	Characterization of the carbohydrate structures of apolipoprotein_H through concanavalin A affinity chromatography .
25256745	0	carbohydrate	38,50	b2-glycoprotein_I	12,29	carbohydrate	b2-glycoprotein I	CHEBI:16646	350	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	The role of b2-glycoprotein_I -LRB- b2GPI -RRB- carbohydrate chains in the reactivity of anti-b2GPI antibodies from patients with primary antiphospholipid_syndrome and in the activation and differentiation of U937 cells .
19383238	0	carbohydrate	82,94	carcinoembryonic_antigen	22,46	carbohydrate	carcinoembryonic antigen	CHEBI:16646	1084	Chemical	Gene	START_ENTITY|nsubj|efficacy efficacy|nmod|END_ENTITY	The efficacy of serum carcinoembryonic_antigen -LRB- CEA -RRB- , cancer antigen 125 -LRB- CA125 -RRB- , carbohydrate antigen 19-9 -LRB- CA19-9 -RRB- , carbohydrate_antigen_15-3 -LRB- CA15-3 -RRB- , alpha-fetoprotein -LRB- AFP -RRB- and human chorionic_gonadotropin _ -LRB- hCG -RRB- levels in determining the malignancy of solitary_pulmonary_nodules .
2431767	0	carbohydrate	116,128	carcinoembryonic_antigen	139,163	carbohydrate	carcinoembryonic antigen	CHEBI:16646	1084	Chemical	Gene	moiety|amod|START_ENTITY moiety|nmod|END_ENTITY	Antigenic heterogeneity of carcinoembryonic_antigen in the circulation defined by monoclonal antibodies against the carbohydrate moiety of carcinoembryonic_antigen and closely related antigens .
25368272	0	carbohydrate	47,59	carcinoembryonic_antigen	21,45	carbohydrate	carcinoembryonic antigen	CHEBI:16646	1084	Chemical	Gene	antigen|amod|START_ENTITY antigen|compound|END_ENTITY	Measurement of serum carcinoembryonic_antigen , carbohydrate antigen 19-9 , cytokeratin-19 fragment and matrix_metalloproteinase-7 for detecting cholangiocarcinoma : a preliminary case-control study .
1648948	0	carbohydrate	9,21	cathepsin_D	91,102	carbohydrate	cathepsin D	CHEBI:16646	1509	Chemical	Gene	START_ENTITY|dobj|activity activity|nmod|END_ENTITY	Elevated carbohydrate phosphotransferase activity in human hepatoma and phosphorylation of cathepsin_D .
1616876	0	carbohydrate	18,30	corticosteroid-binding_globulin	60,91	carbohydrate	corticosteroid-binding globulin	CHEBI:16646	866	Chemical	Gene	composition|amod|START_ENTITY composition|nmod|END_ENTITY	Comparison of the carbohydrate composition of rat and human corticosteroid-binding_globulin : species specific glycosylation .
12355162	0	carbohydrate	64,76	cytosolic_phosphoglucomutase	17,45	carbohydrate	cytosolic phosphoglucomutase	CHEBI:16646	102579912	Chemical	Gene	metabolism|compound|START_ENTITY influence|nmod|metabolism influence|nmod|END_ENTITY	The influence of cytosolic_phosphoglucomutase on photosynthetic carbohydrate metabolism .
4607118	0	carbohydrate	15,27	dopamine_beta-hydroxylase	38,63	carbohydrate	dopamine beta-hydroxylase	CHEBI:16646	1621	Chemical	Gene	moiety|amod|START_ENTITY moiety|nmod|END_ENTITY	Studies on the carbohydrate moiety of dopamine_beta-hydroxylase : interaction of the enzyme with concanavalin A. Dopamine_beta-hydroxylase -LSB- EC 1.14.17.1 ; 3,4-dihydroxyphenylethylamine , ascorbate : oxygen oxidoreductase -LRB- beta-hydroxylating -RRB- -RSB- , a glycoprotein , was found to interact strongly with the plant lectin , concanavalin A .
10998266	0	carbohydrate	148,160	erythropoietin	178,192	carbohydrate	erythropoietin	CHEBI:16646	2056	Chemical	Gene	heterogeneity|compound|START_ENTITY heterogeneity|nmod|END_ENTITY	Application of liquid chromatography/mass spectrometry and liquid chromatography with tandem mass spectrometry to the analysis of the site-specific carbohydrate heterogeneity in erythropoietin .
14757769	0	carbohydrate	48,60	erythropoietin	82,96	carbohydrate	erythropoietin	CHEBI:16646	2056	Chemical	Gene	requirements|nmod|START_ENTITY requirements|nmod|END_ENTITY	Structural requirements for additional N-linked carbohydrate on recombinant human erythropoietin .
1744097	0	carbohydrate	14,26	erythropoietin	61,75	carbohydrate	erythropoietin	CHEBI:16646	2056	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|structure structure|nmod|END_ENTITY	The effect of carbohydrate on the structure and stability of erythropoietin .
2156701	0	carbohydrate	12,24	erythropoietin	46,60	carbohydrate	erythropoietin	CHEBI:16646	2056	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of carbohydrate in recombinant human erythropoietin .
3421710	0	carbohydrate	63,75	erythropoietin	18,32	carbohydrate	erythropoietin	CHEBI:16646	2056	Chemical	Gene	linkage|amod|START_ENTITY purification|nmod|linkage END_ENTITY|dep|purification	Recombinant human erythropoietin : purification and analysis of carbohydrate linkage .
3996313	0	carbohydrate	12,24	erythropoietin	28,42	carbohydrate	erythropoietin	CHEBI:16646	2056	Chemical	Gene	role|nmod|START_ENTITY role|nmod|action action|compound|END_ENTITY	The role of carbohydrate in erythropoietin action .
7539788	0	carbohydrate	55,67	erythropoietin	96,110	carbohydrate	erythropoietin	CHEBI:16646	2056	Chemical	Gene	chains|compound|START_ENTITY chains|nmod|END_ENTITY	Immunogenicity of N-glycolylneuraminic_acid-containing carbohydrate chains of recombinant human erythropoietin expressed in Chinese_hamster ovary cells .
7727375	0	carbohydrate	49,61	erythropoietin	77,91	carbohydrate	erythropoietin	CHEBI:16646	2056	Chemical	Gene	requirements|nmod|START_ENTITY requirements|nmod|END_ENTITY	Structural requirements for addition of O-linked carbohydrate to recombinant erythropoietin .
7737204	0	carbohydrate	54,66	erythropoietin	95,109	carbohydrate	erythropoietin	CHEBI:16646	2056	Chemical	Gene	chains|amod|START_ENTITY analysis|nmod|chains analysis|nmod|END_ENTITY	Structural analysis of the sialylated N - and O-linked carbohydrate chains of recombinant human erythropoietin expressed in Chinese_hamster ovary cells .
8618811	0	carbohydrate	108,120	erythropoietin	57,71	carbohydrate	erythropoietin	CHEBI:16646	2056	Chemical	Gene	metabolism|amod|START_ENTITY regulating|dobj|metabolism hormones|acl|regulating Influence|nmod|hormones Influence|nmod|END_ENTITY	-LSB- Influence of long-term treatment with human recombinant erythropoietin on secretion of hormones regulating carbohydrate metabolism in hemodialyzed patients with chronic_uremia -RSB- .
8639887	0	carbohydrate	129,141	erythropoietin	163,177	carbohydrate	erythropoietin	CHEBI:16646	2056	Chemical	Gene	START_ENTITY|nmod|structure structure|compound|END_ENTITY	Isolation and characterization of conformation sensitive antierythropoietin monoclonal antibodies : effect of disulfide bonds and carbohydrate on recombinant human erythropoietin structure .
15564327	0	carbohydrate	14,26	farnesoid_X_receptor	45,65	carbohydrate	farnesoid X receptor	CHEBI:16646	60351(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY Regulation|nmod|metabolism Regulation|nmod|END_ENTITY	Regulation of carbohydrate metabolism by the farnesoid_X_receptor .
15899888	0	carbohydrate	43,55	farnesoid_X_receptor	4,24	carbohydrate	farnesoid X receptor	CHEBI:16646	20186(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY modulates|dobj|metabolism modulates|nsubj|END_ENTITY	The farnesoid_X_receptor modulates hepatic carbohydrate metabolism during the fasting-refeeding transition .
3569289	0	carbohydrate	56,68	fibrinogen	79,89	carbohydrate	fibrinogen	CHEBI:16646	2244	Chemical	Gene	chains|amod|START_ENTITY chains|nmod|END_ENTITY	Differential binding of mannose-specific lectins to the carbohydrate chains of fibrinogen domains D and E .
12145186	0	carbohydrate	6,18	galectin	45,53	carbohydrate	galectin	CHEBI:16646	183761(Tax:6239)	Chemical	Gene	specificity|compound|START_ENTITY specificity|nmod|END_ENTITY	Novel carbohydrate specificity of the 16-kDa galectin from Caenorhabditis_elegans : binding to blood group precursor oligosaccharides -LRB- type 1 , type 2 , Talpha , and Tbeta -RRB- and gangliosides .
19641853	0	carbohydrate	59,71	galectin-3	94,104	carbohydrate	galectin-3	CHEBI:16646	3958	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Conformational entropy changes upon lactose binding to the carbohydrate recognition domain of galectin-3 .
12851289	0	carbohydrate	15,27	galectin-8	50,60	carbohydrate	galectin-8	CHEBI:16646	3964	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	The N-terminal carbohydrate recognition domain of galectin-8 recognizes specific glycosphingolipids with high affinity .
23175333	0	carbohydrate	48,60	ghrelin	8,15	carbohydrate	ghrelin	CHEBI:16646	100861189	Chemical	Gene	metabolism|amod|START_ENTITY regulation|nmod|metabolism Role|nmod|regulation Role|nmod|END_ENTITY	Role of ghrelin and leptin in the regulation of carbohydrate metabolism .
3818580	0	carbohydrate	18,30	glycoproteins_IIb	50,67	carbohydrate	glycoproteins IIb	CHEBI:16646	3674	Chemical	Gene	chains|amod|START_ENTITY chains|nmod|END_ENTITY	Structures of the carbohydrate chains of membrane glycoproteins_IIb and IIIa of human platelets .
2574581	0	carbohydrate	20,32	gp120	73,78	carbohydrate	gp120	CHEBI:16646	155971(Tax:11676)	Chemical	Gene	structures|amod|START_ENTITY structures|nmod|END_ENTITY	Correlation between carbohydrate structures on the envelope glycoprotein gp120 of HIV-1_and_HIV-2 and syncytium inhibition with lectins .
10822227	0	carbohydrate	42,54	growth_hormone	20,34	carbohydrate	growth hormone	CHEBI:16646	2688	Chemical	Gene	units|amod|START_ENTITY effect|nmod|units effect|nmod|END_ENTITY	The effect of human growth_hormone on the carbohydrate units in arterial_basement_membrane-like_material .
1088895	0	carbohydrate	97,109	growth_hormone	15,29	carbohydrate	growth hormone	CHEBI:16646	81668(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY effects|nmod|metabolism effects|nmod|treatment treatment|amod|END_ENTITY	The effects of growth_hormone treatment of thyroid-deficient pregnant rats on maternal and fetal carbohydrate metabolism .
12466334	0	carbohydrate	67,79	growth_hormone	39,53	carbohydrate	growth hormone	CHEBI:16646	2688	Chemical	Gene	metabolism|amod|START_ENTITY treatment|nmod|metabolism treatment|compound|END_ENTITY	Effect of discontinuation of long-term growth_hormone treatment on carbohydrate metabolism and risk factors for cardiovascular_disease in girls with Turner_syndrome .
1723835	0	carbohydrate	48,60	growth_hormone	20,34	carbohydrate	growth hormone	CHEBI:16646	2688	Chemical	Gene	metabolism|amod|START_ENTITY secretion|nmod|metabolism secretion|amod|END_ENTITY	Impact of increased growth_hormone secretion on carbohydrate metabolism in adolescents with diabetes .
17340066	0	carbohydrate	12,24	growth_hormone	110,124	carbohydrate	growth hormone	CHEBI:16646	2688	Chemical	Gene	metabolism|amod|START_ENTITY Changes|nmod|metabolism Changes|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Changes in carbohydrate metabolism and insulin resistance in patients with Prader-Willi_Syndrome -LRB- PWS -RRB- under growth_hormone therapy -RSB- .
19800274	0	carbohydrate	40,52	growth_hormone	22,36	carbohydrate	growth hormone	CHEBI:16646	2688	Chemical	Gene	metabolism|compound|START_ENTITY effects|nmod|metabolism effects|nmod|END_ENTITY	Biological effects of growth_hormone on carbohydrate and lipid metabolism .
20647047	0	carbohydrate	121,133	growth_hormone	11,25	carbohydrate	growth hormone	CHEBI:16646	2688	Chemical	Gene	enzymes|amod|START_ENTITY expression|nmod|enzymes triiodothyronine|nmod|expression triiodothyronine|nsubj|Effects Effects|nmod|END_ENTITY	Effects of growth_hormone , insulin-like growth factor I , triiodothyronine , thyroxine , and cortisol on gene expression of carbohydrate metabolic enzymes in sea bream hepatocytes .
25097506	0	carbohydrate	55,67	growth_hormone	29,43	carbohydrate	growth hormone	CHEBI:16646	2688	Chemical	Gene	metabolisms|compound|START_ENTITY therapy|nmod|metabolisms therapy|compound|END_ENTITY	Effects of recombinant human growth_hormone therapy on carbohydrate , lipid and protein metabolisms of children with Turner_syndrome .
2778033	0	carbohydrate	8,20	growth_hormone	58,72	carbohydrate	growth hormone	CHEBI:16646	2688	Chemical	Gene	content|amod|START_ENTITY determines|nsubj|content determines|xcomp|END_ENTITY	Dietary carbohydrate content determines responsiveness to growth_hormone in energy-restricted humans .
3301316	0	carbohydrate	28,40	growth_hormone	10,24	carbohydrate	growth hormone	CHEBI:16646	2688	Chemical	Gene	metabolism|compound|START_ENTITY Effect|nmod|metabolism Effect|nmod|END_ENTITY	Effect of growth_hormone on carbohydrate and lipid metabolism .
3537254	0	carbohydrate	124,136	growth_hormone	32,46	carbohydrate	growth hormone	CHEBI:16646	81668(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY produced|nmod|metabolism produced|nsubj|effects effects|nmod|analogue analogue|amod|END_ENTITY	Some biochemical effects of the growth_hormone analogue produced by plerocercoids of the tapeworm Spirometra mansonoides on carbohydrate metabolism of adipose tissue from normal , diabetic , and hypophysectomized rats .
4673906	0	carbohydrate	89,101	growth_hormone	55,69	carbohydrate	growth hormone	CHEBI:16646	2688	Chemical	Gene	metabolism|amod|START_ENTITY aspects|nmod|metabolism bromide|nmod|aspects bromide|dobj|fragment fragment|nmod|END_ENTITY	Lack of effect of a cyanogen bromide fragment of human growth_hormone on some aspects of carbohydrate metabolism in vitro .
5028642	0	carbohydrate	42,54	growth_hormone	16,30	carbohydrate	growth hormone	CHEBI:16646	2688	Chemical	Gene	metabolism|amod|START_ENTITY END_ENTITY|nmod|metabolism	The relation of growth_hormone to altered carbohydrate metabolism in women taking oral contraceptives .
738210	0	carbohydrate	56,68	growth_hormone	9,23	carbohydrate	growth hormone	CHEBI:16646	2688	Chemical	Gene	tolerance|compound|START_ENTITY obesity|nmod|tolerance response|nmod|obesity response|compound|END_ENTITY	Abnormal growth_hormone response in obesity with normal carbohydrate tolerance and normal thyroid function .
9754825	0	carbohydrate	56,68	growth_hormone	32,46	carbohydrate	growth hormone	CHEBI:16646	2688	Chemical	Gene	tolerance|amod|START_ENTITY alter|dobj|tolerance END_ENTITY|xcomp|alter	Failure of nocturnal changes in growth_hormone to alter carbohydrate tolerance the following morning .
9797856	0	carbohydrate	48,60	growth_hormone	20,34	carbohydrate	growth hormone	CHEBI:16646	2688	Chemical	Gene	metabolism|amod|START_ENTITY treatment|nmod|metabolism treatment|compound|END_ENTITY	Effect of long-term growth_hormone treatment on carbohydrate metabolism in children with growth_hormone deficiency .
9797856	0	carbohydrate	48,60	growth_hormone	89,103	carbohydrate	growth hormone	CHEBI:16646	2688	Chemical	Gene	metabolism|amod|START_ENTITY treatment|nmod|metabolism Effect|nmod|treatment Effect|nmod|children children|nmod|deficiency deficiency|amod|END_ENTITY	Effect of long-term growth_hormone treatment on carbohydrate metabolism in children with growth_hormone deficiency .
10205319	0	carbohydrate	18,30	insulin	68,75	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	administration|amod|START_ENTITY reduces|nsubj|administration reduces|dobj|resistance resistance|compound|END_ENTITY	Preoperative oral carbohydrate administration reduces postoperative insulin resistance .
10332663	0	carbohydrate	16,28	insulin	151,158	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	START_ENTITY|xcomp|content content|dep|patients patients|acl|treated treated|advmod|intensively intensively|nmod|regimen regimen|compound|END_ENTITY	Effects of meal carbohydrate content on insulin requirements in type 1 diabetic patients treated intensively with the basal-bolus -LRB- ultralente-regular -RRB- insulin regimen .
10332663	0	carbohydrate	16,28	insulin	40,47	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	START_ENTITY|xcomp|content content|nmod|requirements requirements|compound|END_ENTITY	Effects of meal carbohydrate content on insulin requirements in type 1 diabetic patients treated intensively with the basal-bolus -LRB- ultralente-regular -RRB- insulin regimen .
10697389	0	carbohydrate	20,32	insulin	82,89	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	Changes|nmod|START_ENTITY Changes|dep|role role|nmod|END_ENTITY	Changes in protein , carbohydrate , and fat metabolism with aging : possible role of insulin .
1095439	0	carbohydrate	72,84	insulin	22,29	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	intake|compound|START_ENTITY Basal|nmod|intake Basal|dobj|levels levels|compound|END_ENTITY	Basal and postprotein insulin and glucagon levels during a high and low carbohydrate intake and their relationships to plasma triglycerides .
11254464	0	carbohydrate	18,30	insulin	76,83	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	treatment|amod|START_ENTITY attenuates|nsubj|treatment attenuates|dobj|resistance resistance|compound|END_ENTITY	Preoperative oral carbohydrate treatment attenuates immediate postoperative insulin resistance .
1189493	0	carbohydrate	35,47	insulin	24,31	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	metabolism|compound|START_ENTITY Study|nmod|metabolism Study|nmod|effect effect|nmod|END_ENTITY	-LSB- Study on the effect of insulin on carbohydrate and lipid metabolism in obese subjects with normal glucose tolerance -RSB- .
1193312	0	carbohydrate	24,36	insulin	60,67	carbohydrate	insulin	CHEBI:16646	483665(Tax:9615)	Chemical	Gene	START_ENTITY|nmod|response response|compound|END_ENTITY	Influence of antecedent carbohydrate intake on the biphasic insulin response to intravenous glucose .
11979025	0	carbohydrate	42,54	insulin	82,89	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	intake|amod|START_ENTITY balance|dobj|intake balance|nmod|adjustments adjustments|nmod|END_ENTITY	How do we educate young people to balance carbohydrate intake with adjustments of insulin ?
1201057	0	carbohydrate	52,64	insulin	21,28	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	metabolism|amod|START_ENTITY Interrelationship|nmod|metabolism Interrelationship|nmod|ratios ratios|compound|END_ENTITY	Interrelationship of insulin and glucagon ratios on carbohydrate metabolism in isolated hepatocytes containing high glycogen .
12230794	0	carbohydrate	65,77	insulin	29,36	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	loading|compound|START_ENTITY Modulation|nmod|loading Modulation|nmod|resistance resistance|compound|END_ENTITY	Modulation of post-operative insulin resistance by pre-operative carbohydrate loading .
1230533	0	carbohydrate	87,99	insulin	27,34	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	metabolism|amod|START_ENTITY Content|nmod|metabolism Content|nmod|END_ENTITY	-LSB- Content of immunoreactive insulin and catecholamines in blood plasma and disorders of carbohydrate metabolism in patients with myocardial_infarct -RSB- .
12589186	0	carbohydrate	11,23	insulin	27,34	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	Fat versus carbohydrate in insulin resistance , obesity , diabetes and cardiovascular_disease .
12600851	0	carbohydrate	60,72	insulin	105,112	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	START_ENTITY|nmod|glucose glucose|appos|END_ENTITY	Long-term effect of varying the source or amount of dietary carbohydrate on postprandial plasma glucose , insulin , triacylglycerol , and free fatty_acid concentrations in subjects with impaired_glucose_tolerance .
12705369	0	carbohydrate	45,57	insulin	18,25	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	metabolism|compound|START_ENTITY supplementation|nmod|metabolism supplementation|nsubj|Influence Influence|nmod|END_ENTITY	Influence of oral insulin supplementation on carbohydrate , lipid and protein metabolism in weaned Balb/c mice .
1490682	0	carbohydrate	79,91	insulin	50,57	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	meal|amod|START_ENTITY Timing|nmod|meal Timing|nmod|administration administration|nmod|END_ENTITY	Timing between the subcutaneous administration of insulin and consumption of a carbohydrate rich meal .
156932	0	carbohydrate	16,28	insulin	7,14	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	fatty_acid|dep|START_ENTITY changes|amod|fatty_acid END_ENTITY|appos|changes	Plasma insulin , carbohydrate , and free fatty_acid changes in newly born infants of diabetic and non-diabetic mothers after loading with glucose , _ fructose , _ and_galactose .
15853306	0	carbohydrate	39,51	insulin	11,18	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	control|amod|START_ENTITY Reversible|nmod|control Reversible|dobj|self-assembly self-assembly|compound|END_ENTITY	Reversible insulin self-assembly under carbohydrate control .
16332654	0	carbohydrate	8,20	insulin	43,50	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	modification|amod|START_ENTITY enhances|nsubj|modification enhances|dobj|secretion secretion|compound|END_ENTITY	Dietary carbohydrate modification enhances insulin secretion in persons with the metabolic_syndrome .
17494126	0	carbohydrate	14,26	insulin	131,138	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	exposure|amod|START_ENTITY Importance|nmod|exposure Importance|nmod|therapy therapy|nmod|administration administration|nmod|glargine glargine|compound|END_ENTITY	Importance of carbohydrate exposure before and after conversion from intravenous insulin therapy to subcutaneous administration of insulin glargine .
17494126	0	carbohydrate	14,26	insulin	81,88	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	exposure|amod|START_ENTITY Importance|nmod|exposure Importance|nmod|therapy therapy|compound|END_ENTITY	Importance of carbohydrate exposure before and after conversion from intravenous insulin therapy to subcutaneous administration of insulin glargine .
19114407	0	carbohydrate	42,54	insulin	163,170	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	diet|compound|START_ENTITY experience|nmod|diet improves|nsubj|experience improves|dobj|sensitivity sensitivity|nmod|women women|amod|END_ENTITY	Clinical experience with a relatively low carbohydrate , calorie-restricted diet improves insulin sensitivity and associated metabolic_abnormalities in overweight , insulin resistant South Asian Indian women .
19114407	0	carbohydrate	42,54	insulin	89,96	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	diet|compound|START_ENTITY experience|nmod|diet improves|nsubj|experience improves|dobj|sensitivity sensitivity|compound|END_ENTITY	Clinical experience with a relatively low carbohydrate , calorie-restricted diet improves insulin sensitivity and associated metabolic_abnormalities in overweight , insulin resistant South Asian Indian women .
196374	0	carbohydrate	34,46	insulin	11,18	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	enzymes|amod|START_ENTITY activity|nmod|enzymes END_ENTITY|nmod|activity	-LSB- Effect of insulin on activity of carbohydrate metabolism enzymes in loach embryos in early development -RSB- .
20696267	0	carbohydrate	137,149	insulin	8,15	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	levels|amod|START_ENTITY fed|nmod|levels Role|acl|fed Role|nmod|END_ENTITY	Role of insulin and IGF-I on the regulation of glucose metabolism in European sea bass -LRB- Dicentrarchus labrax -RRB- fed with different dietary carbohydrate levels .
21575079	0	carbohydrate	44,56	insulin	64,71	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	Effects|nmod|START_ENTITY hay|nsubj|Effects hay|nmod|triglyceride triglyceride|compound|END_ENTITY	Effects of high and moderate non-structural carbohydrate hay on insulin , glucose , triglyceride , and leptin concentrations in overweight Arabian geldings .
22765260	0	carbohydrate	81,93	insulin	107,114	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	START_ENTITY|acl|counting counting|nmod|END_ENTITY	Benefit of supplementary fat plus protein counting as compared with conventional carbohydrate counting for insulin bolus calculation in children with pump therapy .
22853297	0	carbohydrate	30,42	insulin	51,58	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	conjunction|nmod|START_ENTITY Aspartame|nmod|conjunction reduces|nsubj|Aspartame reduces|dobj|levels levels|compound|END_ENTITY	Aspartame in conjunction with carbohydrate reduces insulin levels during endurance exercise .
23591152	0	carbohydrate	26,38	insulin	125,132	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	protein|acl|START_ENTITY Increasing|dobj|protein reduces|csubj|Increasing reduces|dobj|independent independent|nmod|END_ENTITY	Increasing the protein to carbohydrate ratio in yogurts consumed as a snack reduces post-consumption glycemia independent of insulin .
23683103	0	carbohydrate	32,44	insulin	14,21	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	metabolism|amod|START_ENTITY action|nmod|metabolism action|compound|END_ENTITY	Assessment of insulin action on carbohydrate metabolism : physiological and non-physiological methods .
24252674	0	carbohydrate	30,42	insulin	60,67	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	-LSB- Effects of preoperative oral carbohydrate on postoperative insulin resistance in radical gastrectomy patients -RSB- .
24548145	0	carbohydrate	43,55	insulin	67,74	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	intake|amod|START_ENTITY intake|nmod|resistance resistance|compound|END_ENTITY	CRY1 circadian gene variant interacts with carbohydrate intake for insulin resistance in two independent populations : Mediterranean and North American .
24843736	0	carbohydrate	21,33	insulin	119,126	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	ratio|amod|START_ENTITY variation|nmod|ratio treated|nsubj|variation treated|nmod|infusion infusion|compound|END_ENTITY	Diurnal variation of carbohydrate insulin ratio in adult type 1 diabetic patients treated with continuous subcutaneous insulin infusion .
24843736	0	carbohydrate	21,33	insulin	34,41	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	ratio|amod|START_ENTITY ratio|compound|END_ENTITY	Diurnal variation of carbohydrate insulin ratio in adult type 1 diabetic patients treated with continuous subcutaneous insulin infusion .
2500169	0	carbohydrate	117,129	insulin	15,22	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	metabolism|compound|START_ENTITY effects|nmod|metabolism study|nmod|effects Sensitivity|dep|study Sensitivity|nmod|END_ENTITY	Sensitivity to insulin during treatment with atenolol and metoprolol : a randomised , double blind study of effects on carbohydrate and lipoprotein metabolism in hypertensive patients .
2575575	0	carbohydrate	122,134	insulin	111,118	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	metabolism|amod|START_ENTITY END_ENTITY|nmod|metabolism	Inhibition of basal insulin secretion induces insulin resistance in normal man : evidence for a tonic effect of insulin on carbohydrate metabolism .
2575575	0	carbohydrate	122,134	insulin	20,27	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	metabolism|amod|START_ENTITY insulin|nmod|metabolism effect|nmod|insulin evidence|nmod|effect induces|parataxis|evidence induces|nsubj|Inhibition Inhibition|nmod|secretion secretion|compound|END_ENTITY	Inhibition of basal insulin secretion induces insulin resistance in normal man : evidence for a tonic effect of insulin on carbohydrate metabolism .
2575575	0	carbohydrate	122,134	insulin	46,53	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	metabolism|amod|START_ENTITY insulin|nmod|metabolism effect|nmod|insulin evidence|nmod|effect induces|parataxis|evidence induces|dobj|resistance resistance|compound|END_ENTITY	Inhibition of basal insulin secretion induces insulin resistance in normal man : evidence for a tonic effect of insulin on carbohydrate metabolism .
26164007	3	carbohydrate	492,504	insulin	468,475	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	dosing|advcl|START_ENTITY END_ENTITY|acl|dosing	On two surgical units at a tertiary care teaching hospital , we pilot tested postmeal insulin dosing based on carbohydrate counting -LRB- plus basal insulin -RRB- rather than the current process of ordering scheduled premeal insulin without knowledge of the patient 's consumption .
26704011	0	carbohydrate	36,48	insulin	66,73	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	-LSB- Impact of preoperative oral liquid carbohydrate on postoperative insulin resistance in gastric_cancer patients and its associated study -RSB- .
3006377	0	carbohydrate	31,43	insulin	9,16	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	-RSB-|amod|START_ENTITY regulating|dobj|-RSB- END_ENTITY|acl|regulating	-LSB- Role of insulin in regulating carbohydrate metabolism -RSB- .
3517028	0	carbohydrate	76,88	insulin	46,53	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	regulate|xcomp|START_ENTITY ability|acl|regulate ability|nmod:poss|END_ENTITY	Effect of differences in glucose_tolerance on insulin 's ability to regulate carbohydrate and free fatty_acid metabolism in obese individuals .
4288304	0	carbohydrate	28,40	insulin	63,70	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	enzymes|compound|START_ENTITY pattern|nmod|enzymes pattern|dep|END_ENTITY	Regulatory pattern of liver carbohydrate metabolizing enzymes : insulin as inducer of key glycolytic enzymes .
4298939	0	carbohydrate	95,107	insulin	69,76	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	metabolism|amod|START_ENTITY activity|nmod|metabolism activity|nmod|administration administration|compound|END_ENTITY	Insulin-like activity in experimental tuberculosis and the effect of insulin administration on carbohydrate metabolism .
4355806	0	carbohydrate	41,53	insulin	10,17	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	metabolism|amod|START_ENTITY Effect|nmod|metabolism Effect|nmod|END_ENTITY	Effect of insulin and epinephrine on the carbohydrate metabolism and adenylate cyclase activity of rhesus fetal muscle .
446930	0	carbohydrate	17,29	insulin	38,45	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	diet|compound|START_ENTITY diet|nmod|END_ENTITY	Effect of a high carbohydrate diet on insulin binding to adipocytes and on insulin action in vivo in man .
4978358	0	carbohydrate	25,37	insulin	10,17	carbohydrate	insulin	CHEBI:16646	704534(Tax:9544)	Chemical	Gene	metabolism|amod|START_ENTITY Effect|nmod|metabolism Effect|nmod|END_ENTITY	Effect of insulin on the carbohydrate metabolism of fetal rhesus_monkey muscle .
5150192	0	carbohydrate	57,69	insulin	18,25	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	type|nmod|START_ENTITY related|nmod|type related|nsubj|Changes Changes|nmod|END_ENTITY	Changes in plasma insulin related to the type of dietary carbohydrate in overweight hyperlipidemic male patients .
5492253	0	carbohydrate	32,44	insulin	7,14	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Plasma insulin response to oral carbohydrate in patients with glucose_and_lactose_malabsorption .
590207	0	carbohydrate	66,78	insulin	11,18	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	tolerance|amod|START_ENTITY lipolysis|nmod|tolerance lipolysis|nsubj|Effect Effect|nmod|END_ENTITY	-LSB- Effect of insulin on stimulated lipolysis in obesity with normal carbohydrate tolerance and unimpaired thyroid function -RSB- .
6124363	0	carbohydrate	32,44	insulin	21,28	carbohydrate	insulin	CHEBI:16646	280829(Tax:9913)	Chemical	Gene	metabolism|amod|START_ENTITY effects|nmod|metabolism effects|nmod|END_ENTITY	`` In vivo '' effects of insulin on carbohydrate metabolism of catfish -LRB- Ictalurus melas -RRB- .
7023506	0	carbohydrate	22,34	insulin	11,18	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	metabolism|amod|START_ENTITY Effect|nmod|metabolism Effect|nmod|END_ENTITY	-LSB- Effect of insulin on carbohydrate metabolism in the catfish -LRB- Ictalurus_melas -RRB- .
7552234	0	carbohydrate	45,57	insulin	15,22	carbohydrate	insulin	CHEBI:16646	280829(Tax:9913)	Chemical	Gene	excipients|amod|START_ENTITY Aggregation|nmod|excipients Aggregation|nmod|END_ENTITY	Aggregation of insulin and its prevention by carbohydrate excipients .
7789632	0	carbohydrate	60,72	insulin	91,98	carbohydrate	insulin	CHEBI:16646	483665(Tax:9615)	Chemical	Gene	metabolism|amod|START_ENTITY Effects|nmod|metabolism Effects|nmod|deficiency deficiency|compound|END_ENTITY	Effects of an acute increase in epinephrine and cortisol on carbohydrate metabolism during insulin deficiency .
8178983	0	carbohydrate	40,52	insulin	71,78	carbohydrate	insulin	CHEBI:16646	483665(Tax:9615)	Chemical	Gene	metabolism|amod|START_ENTITY Effects|nmod|metabolism Effects|nmod|deficiency deficiency|compound|END_ENTITY	Effects of chronic hypercortisolemia on carbohydrate metabolism during insulin deficiency .
8604670	0	carbohydrate	9,21	insulin	49,56	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	Types|nmod|START_ENTITY affect|nsubj|Types affect|dobj|action action|compound|END_ENTITY	Types of carbohydrate in an ordinary diet affect insulin action and muscle substrates in humans .
8636416	0	carbohydrate	58,70	insulin	156,163	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	tolerance|amod|START_ENTITY Effects|nmod|tolerance Effects|nmod|degrees degrees|nmod|resistance resistance|compound|END_ENTITY	Effects of a change in the pattern of insulin delivery on carbohydrate tolerance in diabetic and nondiabetic humans in the presence of differing degrees of insulin resistance .
8636416	0	carbohydrate	58,70	insulin	38,45	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	tolerance|amod|START_ENTITY Effects|nmod|tolerance Effects|nmod|delivery delivery|compound|END_ENTITY	Effects of a change in the pattern of insulin delivery on carbohydrate tolerance in diabetic and nondiabetic humans in the presence of differing degrees of insulin resistance .
8637438	0	carbohydrate	27,39	insulin	43,50	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|response response|compound|END_ENTITY	The effect of low-glycemic carbohydrate on insulin and glucose response in vivo and in vitro in patients with coronary_heart_disease .
9349592	0	carbohydrate	56,68	insulin	36,43	carbohydrate	insulin	CHEBI:16646	397415(Tax:9823)	Chemical	Gene	metabolism|compound|START_ENTITY delivery|nmod|metabolism delivery|compound|END_ENTITY	The effect of portal and peripheral insulin delivery on carbohydrate and lipid metabolism in a miniature pig model of human IDDM .
9734735	0	carbohydrate	123,135	insulin	15,22	carbohydrate	insulin	CHEBI:16646	3630	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of insulin , glucagon-like_peptide_1 , gastric inhibitory polypeptide , and appetite in response to intraduodenal carbohydrate .
1993068	0	carbohydrate	11,23	insulin_receptor	43,59	carbohydrate	insulin receptor	CHEBI:16646	3643	Chemical	Gene	sites|amod|START_ENTITY Mapping|nmod|sites Mapping|nmod|END_ENTITY	Mapping of carbohydrate sites on the human insulin_receptor .
2990467	0	carbohydrate	37,49	insulin_receptor	20,36	carbohydrate	insulin receptor	CHEBI:16646	3643	Chemical	Gene	START_ENTITY|nsubj|Characterization Characterization|nmod|END_ENTITY	Characterization of insulin_receptor carbohydrate by comparison of chemical and enzymatic deglycosylation .
3512253	0	carbohydrate	38,50	insulin_receptor	21,37	carbohydrate	insulin receptor	CHEBI:16646	100766818	Chemical	Gene	composition|compound|START_ENTITY composition|compound|END_ENTITY	Lectins as probes of insulin_receptor carbohydrate composition : studies in glycosylation mutants of Chinese_hamster ovarian cells with altered insulin binding .
8179619	0	carbohydrate	31,43	insulin_receptor	58,74	carbohydrate	insulin receptor	CHEBI:16646	3643	Chemical	Gene	chains|amod|START_ENTITY chains|nmod|END_ENTITY	Effect of dexamethasone on the carbohydrate chains of the insulin_receptor .
9933650	0	carbohydrate	19,31	interleukin-1	52,65	carbohydrate	interleukin-1	CHEBI:16646	3552	Chemical	Gene	START_ENTITY|dobj|activity activity|nmod|END_ENTITY	Detection of novel carbohydrate binding activity of interleukin-1 .
11771681	0	carbohydrate	67,79	leptin	11,17	carbohydrate	leptin	CHEBI:16646	3952	Chemical	Gene	load|compound|START_ENTITY metabolism|nmod|load Effects|nmod|metabolism Effects|nmod|resistance resistance|compound|END_ENTITY	Effects of leptin resistance on acute fuel metabolism after a high carbohydrate load in lean and overweight young men .
12679442	0	carbohydrate	81,93	leptin	9,15	carbohydrate	leptin	CHEBI:16646	3952	Chemical	Gene	diet|compound|START_ENTITY caused|nmod|diet caused|nsubj|Roles Roles|nmod|END_ENTITY	Roles of leptin and ghrelin in the loss of body weight caused by a low fat , high carbohydrate diet .
12753550	0	carbohydrate	27,39	leptin	58,64	carbohydrate	leptin	CHEBI:16646	443534(Tax:9940)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretions secretions|compound|END_ENTITY	Effects of short-term high carbohydrate or fat intakes on leptin , growth_hormone and luteinizing hormone secretions in prepubertal fat-tailed Tuj lambs .
17089566	0	carbohydrate	46,58	leptin	91,97	carbohydrate	leptin	CHEBI:16646	3952	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|nmod|END_ENTITY	-LSB- The influence hypocaloric diet on induces of carbohydrate metabolism and concentration of leptin and soluble leptin_receptor in the blood serum of the type 2 diabetic patients -RSB- .
21717410	0	carbohydrate	40,52	leptin	12,18	carbohydrate	leptin	CHEBI:16646	16846(Tax:10090)	Chemical	Gene	metabolism|amod|START_ENTITY regulation|nmod|metabolism role|nmod|regulation role|nmod|END_ENTITY	The role of leptin in the regulation of carbohydrate metabolism .
9084976	7	carbohydrate	1163,1175	leptin	1239,1245	carbohydrate	leptin	CHEBI:16646	3952	Chemical	Gene	intake|compound|START_ENTITY pronounced|nmod|intake pronounced|advcl|suggests suggests|dobj|role role|nmod|END_ENTITY	This pronounced fall in serum leptin in association with reduced carbohydrate intake before substantial loss of body fat suggests a role for leptin in defending the body 's carbohydrate stores and implicates leptin in the satiating effects of carbohydrate .
9084976	7	carbohydrate	1270,1282	leptin	1239,1245	carbohydrate	leptin	CHEBI:16646	3952	Chemical	Gene	stores|amod|START_ENTITY defending|dobj|stores suggests|advcl|defending suggests|dobj|role role|nmod|END_ENTITY	This pronounced fall in serum leptin in association with reduced carbohydrate intake before substantial loss of body fat suggests a role for leptin in defending the body 's carbohydrate stores and implicates leptin in the satiating effects of carbohydrate .
9084976	7	carbohydrate	1340,1352	leptin	1239,1245	carbohydrate	leptin	CHEBI:16646	3952	Chemical	Gene	effects|nmod|START_ENTITY defending|nmod|effects suggests|advcl|defending suggests|dobj|role role|nmod|END_ENTITY	This pronounced fall in serum leptin in association with reduced carbohydrate intake before substantial loss of body fat suggests a role for leptin in defending the body 's carbohydrate stores and implicates leptin in the satiating effects of carbohydrate .
8885835	0	carbohydrate	10,22	lysozyme	56,64	carbohydrate	lysozyme	CHEBI:16646	4069	Chemical	Gene	specificity|amod|START_ENTITY specificity|nmod|END_ENTITY	Origin of carbohydrate recognition specificity of human lysozyme revealed by affinity labeling .
12016228	0	carbohydrate	110,122	mMGL1	140,145	carbohydrate	mMGL1	CHEBI:16646	17312(Tax:10090)	Chemical	Gene	specificity|compound|START_ENTITY specificity|nmod|END_ENTITY	Molecular cloning and characterization of a novel mouse macrophage C-type lectin , mMGL2 , which has a distinct carbohydrate specificity from mMGL1 .
10070964	0	carbohydrate	60,72	mucin	89,94	carbohydrate	mucin	CHEBI:16646	100508689	Chemical	Gene	epitope|compound|START_ENTITY express|dobj|epitope express|nmod|glycans glycans|compound|END_ENTITY	Human colon_adenocarcinomas express a MUC1-associated novel carbohydrate epitope on core mucin glycans defined by a monoclonal antibody -LRB- A10 -RRB- raised against murine Ehrlich tumor cells .
10444252	0	carbohydrate	60,72	mucin	103,108	carbohydrate	mucin	CHEBI:16646	100508689	Chemical	Gene	epitopes|compound|START_ENTITY epitopes|nmod|END_ENTITY	Pigeon fanciers ' lung : identification of disease-associated carbohydrate epitopes on pigeon intestinal mucin .
10600032	0	carbohydrate	105,117	mucin	47,52	carbohydrate	mucin	CHEBI:16646	100508689	Chemical	Gene	chains|amod|START_ENTITY containing|dobj|chains recognizes|dep|containing END_ENTITY|acl:relcl|recognizes	A monoclonal antibody against hamster tracheal mucin , which recognizes N-acetyl-galactosamine containing carbohydrate chains as an epitope .
12386453	0	carbohydrate	51,63	mucin	13,18	carbohydrate	mucin	CHEBI:16646	100508689	Chemical	Gene	determinants|amod|START_ENTITY combinatory|nmod|determinants glycosylation|dep|combinatory glycosylation|compound|END_ENTITY	Human airway mucin glycosylation : a combinatory of carbohydrate determinants which vary in cystic_fibrosis .
12944557	0	carbohydrate	154,166	mucin	90,95	carbohydrate	mucin	CHEBI:16646	100508689	Chemical	Gene	epitope|amod|START_ENTITY comparison|nmod|epitope comparison|nmod|END_ENTITY	Detection of sulfated glycoproteins in intestinal metaplasia : a comparison of traditional mucin staining with immunohistochemistry for the sulfo-Lewis -LRB- a -RRB- carbohydrate epitope .
1323463	0	carbohydrate	100,112	mucin	143,148	carbohydrate	mucin	CHEBI:16646	404104(Tax:9913)	Chemical	Gene	chains|compound|START_ENTITY chains|nmod|END_ENTITY	Characterisation by mass spectrometry and 1H-NMR of novel hexasaccharides among the acidic O-linked carbohydrate chains of bovine submaxillary mucin .
16584311	0	carbohydrate	78,90	mucin	118,123	carbohydrate	mucin	CHEBI:16646	404104(Tax:9913)	Chemical	Gene	fragments|amod|START_ENTITY fragments|acl|generated generated|nmod|degradation degradation|compound|END_ENTITY	Vancomycin-resistant Enterococci may obtain nutritional support by scavenging carbohydrate fragments generated during mucin degradation by the anaerobic microbiota of the colon .
17582096	0	carbohydrate	20,32	mucin	84,89	carbohydrate	mucin	CHEBI:16646	404104(Tax:9913)	Chemical	Gene	structures|amod|START_ENTITY Characterization|nmod|structures Characterization|nmod|END_ENTITY	Characterization of carbohydrate structures of bovine MUC15 and distribution of the mucin in bovine milk .
2323510	0	carbohydrate	4,16	mucin	32,37	carbohydrate	mucin	CHEBI:16646	100508689	Chemical	Gene	composition|amod|START_ENTITY composition|nmod|END_ENTITY	The carbohydrate composition of mucin in colonic_cancer .
7499214	0	carbohydrate	154,166	mucin	148,153	carbohydrate	mucin	CHEBI:16646	100508689	Chemical	Gene	chains|compound|START_ENTITY chains|compound|END_ENTITY	Characterization of a sulfotransferase from human airways responsible for the 3-O-sulfation of terminal galactose in N-acetyllactosamine-containing mucin carbohydrate chains .
7507882	0	carbohydrate	30,42	mucin	97,102	carbohydrate	mucin	CHEBI:16646	65202(Tax:10116)	Chemical	Gene	moiety|amod|START_ENTITY antibody|nmod|moiety surface|nsubj|antibody surface|dobj|END_ENTITY	A monoclonal antibody against carbohydrate moiety of rat gastric surface epithelial cell-derived mucin .
8054719	1	carbohydrate	194,206	mucin	188,193	carbohydrate	mucin	CHEBI:16646	100508689	Chemical	Gene	START_ENTITY|nsubj|Characterization Characterization|nmod|type type|nmod|END_ENTITY	Characterization of a novel type of mucin carbohydrate core structure .
8132328	0	carbohydrate	140,152	mucin	134,139	carbohydrate	mucin	CHEBI:16646	100508689	Chemical	Gene	moiety|compound|START_ENTITY moiety|compound|END_ENTITY	Binding of Yersinia_enterocolitica to purified , native small intestinal mucins from rabbits and humans involves interactions with the mucin carbohydrate moiety .
8623771	0	carbohydrate	20,32	mucin	14,19	carbohydrate	mucin	CHEBI:16646	100508689	Chemical	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of mucin carbohydrate antigens -LRB- T , Tn and sialyl_Tn -RRB- and MUC-1 gene product in intraductal_papillary-mucinous_neoplasm of the pancreas .
8809027	0	carbohydrate	51,63	mucin	74,79	carbohydrate	mucin	CHEBI:16646	100508689	Chemical	Gene	moiety|amod|START_ENTITY moiety|nmod|END_ENTITY	Peripheral alpha-linked N-acetylglucosamine on the carbohydrate moiety of mucin derived from mammalian gastric gland mucous cells : epitope recognized by a newly characterized monoclonal antibody .
890979	0	carbohydrate	18,30	mucin	58,63	carbohydrate	mucin	CHEBI:16646	100508689	Chemical	Gene	chains|amod|START_ENTITY chains|nmod|END_ENTITY	-LSB- Heterogeneity of carbohydrate chains of acidic bronchial mucin isolated from the spatum of two subjects with chronic bronchitis -RSB- .
9368010	0	carbohydrate	110,122	mucin	104,109	carbohydrate	mucin	CHEBI:16646	100508689	Chemical	Gene	START_ENTITY|nsubj|Characterization Characterization|nmod|mucosa mucosa|amod|active active|nmod|END_ENTITY	Characterization of an N-acetylglucosamine-6-O-sulfotransferase from human respiratory mucosa active on mucin carbohydrate chains .
9590134	0	carbohydrate	108,120	mucin	102,107	carbohydrate	mucin	CHEBI:16646	100508689	Chemical	Gene	length|amod|START_ENTITY END_ENTITY|dobj|length	Liver_metastasis and adhesion to the sinusoidal endothelium by human colon_cancer cells is related to mucin carbohydrate chain length .
9853552	0	carbohydrate	23,35	mucin	63,68	carbohydrate	mucin	CHEBI:16646	100508689	Chemical	Gene	chain|compound|START_ENTITY chain|nmod|END_ENTITY	Expression of sulfated carbohydrate chain and core peptides of mucin detected by monoclonal antibodies in Barrett 's _ esophagus and esophageal_adenocarcinoma .
6386828	0	carbohydrate	17,29	neural_cell_adhesion_molecule	83,112	carbohydrate	neural cell adhesion molecule	CHEBI:16646	4684	Chemical	Gene	sites|amod|START_ENTITY Mapping|nmod|sites Mapping|nmod|END_ENTITY	Mapping of three carbohydrate attachment sites in embryonic and adult forms of the neural_cell_adhesion_molecule .
15115911	0	carbohydrate	77,89	neuroglycan_C	100,113	carbohydrate	neuroglycan C	CHEBI:16646	50568(Tax:10116)	Chemical	Gene	moiety|amod|START_ENTITY moiety|nmod|END_ENTITY	Developmental changes in the biochemical and immunological characters of the carbohydrate moiety of neuroglycan_C , a brain-specific chondroitin sulfate proteoglycan .
6963110	0	carbohydrate	45,57	neurotensin	12,23	carbohydrate	neurotensin	CHEBI:16646	4922	Chemical	Gene	metabolism|amod|START_ENTITY regulation|nmod|metabolism role|nmod|regulation role|nmod|END_ENTITY	The role of neurotensin in the regulation of carbohydrate metabolism and in diabetes .
23132587	0	carbohydrate	69,81	nucleolin	111,120	carbohydrate	nucleolin	CHEBI:16646	4691	Chemical	Gene	chains|amod|START_ENTITY chains|nmod|END_ENTITY	Macrophage recognition of thiol-group oxidized cells : recognition of carbohydrate chains by macrophage surface nucleolin as apoptotic cells .
10485384	0	carbohydrate	15,27	phospholipase_A2	31,47	carbohydrate	phospholipase A2	CHEBI:16646	406141(Tax:7460)	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of carbohydrate on phospholipase_A2 , a bee-venom allergen , in in vivo antigen-specific IgE synthesis in mice .
3543679	0	carbohydrate	48,60	proinsulin	34,44	carbohydrate	proinsulin	CHEBI:16646	3630	Chemical	Gene	metabolism|amod|START_ENTITY effects|nmod|metabolism effects|nmod|END_ENTITY	The effects of biosynthetic human proinsulin on carbohydrate metabolism in non-insulin-dependent_diabetes_mellitus .
3886457	0	carbohydrate	47,59	proinsulin	23,33	carbohydrate	proinsulin	CHEBI:16646	3630	Chemical	Gene	START_ENTITY|nsubj|action action|nmod|END_ENTITY	Insulin-like action of proinsulin on rat liver carbohydrate metabolism in vitro .
6378699	0	carbohydrate	48,60	proinsulin	34,44	carbohydrate	proinsulin	CHEBI:16646	3630	Chemical	Gene	metabolism|amod|START_ENTITY effects|nmod|metabolism effects|nmod|END_ENTITY	The effects of biosynthetic human proinsulin on carbohydrate metabolism .
3920047	0	carbohydrate	38,50	prostaglandin_endoperoxide_synthase	61,96	carbohydrate	prostaglandin endoperoxide synthase	CHEBI:16646	443551(Tax:9940)	Chemical	Gene	chains|amod|START_ENTITY chains|nmod|END_ENTITY	Determination of the structure of the carbohydrate chains of prostaglandin_endoperoxide_synthase from sheep .
7309709	0	carbohydrate	33,45	prothrombin	62,73	carbohydrate	prothrombin	CHEBI:16646	2147	Chemical	Gene	moiety|amod|START_ENTITY moiety|nmod|END_ENTITY	Studies on the structures of the carbohydrate moiety of human prothrombin .
15341523	0	carbohydrate	120,132	receptor_for_advanced_glycation_end_products	28,72	carbohydrate	receptor for advanced glycation end products	CHEBI:16646	11596(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Developmental expression of receptor_for_advanced_glycation_end_products -LRB- RAGE -RRB- , amphoterin and sulfoglucuronyl -LRB- HNK-1 -RRB- carbohydrate in mouse cerebellum and their role in neurite outgrowth and cell migration .
592816	0	carbohydrate	21,33	rhodopsin	60,69	carbohydrate	rhodopsin	CHEBI:16646	6010	Chemical	Gene	moiety|amod|START_ENTITY moiety|nmod|END_ENTITY	Accessibility of the carbohydrate moiety of membrane-boound rhodopsin to enzymatic and chemical modification .
9435448	0	carbohydrate	69,81	sex_hormone-binding_globulin	14,42	carbohydrate	sex hormone-binding globulin	CHEBI:16646	100009224(Tax:9986)	Chemical	Gene	chain|compound|START_ENTITY END_ENTITY|nmod|chain	Human_variant sex_hormone-binding_globulin -LRB- SHBG -RRB- with an additional carbohydrate chain has a reduced clearance rate in rabbit .
2876501	0	carbohydrate	43,55	somatostatin	11,23	carbohydrate	somatostatin	CHEBI:16646	6750	Chemical	Gene	metabolism|amod|START_ENTITY Effects|nmod|metabolism Effects|nmod|END_ENTITY	Effects of somatostatin and SMS 201-995 on carbohydrate metabolism in normal man .
439779	0	carbohydrate	29,41	somatostatin	13,25	carbohydrate	somatostatin	CHEBI:16646	6750	Chemical	Gene	absorption|amod|START_ENTITY Influence|nmod|absorption Influence|nmod|END_ENTITY	Influence of somatostatin on carbohydrate absorption in human small intestine .
6134474	0	carbohydrate	56,68	somatostatin	11,23	carbohydrate	somatostatin	CHEBI:16646	403993(Tax:9615)	Chemical	Gene	metabolism|amod|START_ENTITY modify|nmod|metabolism Failure|acl|modify Failure|nmod|END_ENTITY	Failure of somatostatin to modify effect of glucagon on carbohydrate metabolism in the dog .
63040	0	carbohydrate	29,41	somatostatin	13,25	carbohydrate	somatostatin	CHEBI:16646	6750	Chemical	Gene	disposal|amod|START_ENTITY Influence|nmod|disposal Influence|nmod|END_ENTITY	Influence of somatostatin on carbohydrate disposal and absorption in diabetes_mellitus .
20601494	0	carbohydrate	64,76	surfactant_protein_D	99,119	carbohydrate	surfactant protein D	CHEBI:16646	6441	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Monoclonal antibody-assisted structure-function analysis of the carbohydrate recognition domain of surfactant_protein_D .
7947964	0	carbohydrate	4,16	thiostatin	83,93	carbohydrate	thiostatin	CHEBI:16646	24903(Tax:10116)	Chemical	Gene	structure|amod|START_ENTITY structure|nmod|END_ENTITY	The carbohydrate structure of the asparagine-linked oligosaccharides of rat plasma thiostatin .
1391595	0	carbohydrate	12,24	thyroid_peroxidase	43,61	carbohydrate	thyroid peroxidase	CHEBI:16646	7173	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Analysis of carbohydrate residues on human thyroid_peroxidase -LRB- TPO -RRB- and thyroglobulin -LRB- Tg -RRB- and effects of deglycosylation , reduction and unfolding on autoantibody binding .
3937276	0	carbohydrate	39,51	tissue-type_plasminogen_activator	62,95	carbohydrate	tissue-type plasminogen activator	CHEBI:16646	5327	Chemical	Gene	moiety|amod|START_ENTITY moiety|nmod|END_ENTITY	On the composition and function of the carbohydrate moiety of tissue-type_plasminogen_activator from human melanoma cells .
7055606	0	carbohydrate	31,43	transcortin	60,71	carbohydrate	transcortin	CHEBI:16646	866	Chemical	Gene	moiety|amod|START_ENTITY moiety|nmod|END_ENTITY	Structural organization of the carbohydrate moiety of human transcortin as determined by methylation analysis of the whole glycoprotein .
15536627	0	carbohydrate	14,26	transferrin	46,57	carbohydrate	transferrin	CHEBI:16646	7018	Chemical	Gene	START_ENTITY|xcomp|profiling profiling|nmod|END_ENTITY	Site-specific carbohydrate profiling of human transferrin by nano-flow liquid chromatography/electrospray ionization mass spectrometry .
15936310	0	carbohydrate	17,29	transferrin	40,51	carbohydrate	transferrin	CHEBI:16646	7018	Chemical	Gene	isoforms|amod|START_ENTITY isoforms|compound|END_ENTITY	HPLC analysis of carbohydrate deficient transferrin isoforms isolated by the Axis-Shield % CDT method .
19654087	0	carbohydrate	16,28	transferrin	39,50	carbohydrate	transferrin	CHEBI:16646	7018	Chemical	Gene	measurement|amod|START_ENTITY measurement|compound|END_ENTITY	-LSB- Improvement of carbohydrate deficient transferrin measurement by capillary zone electrophoresis using immunosubtraction of immunoglobulins and transferrin -RSB- .
2070783	0	carbohydrate	13,25	transferrin	50,61	carbohydrate	transferrin	CHEBI:16646	7018	Chemical	Gene	moieties|amod|START_ENTITY Influence|nmod|moieties END_ENTITY|nsubj|Influence	Influence of carbohydrate moieties of human serum transferrin on the determination of its molecular mass by polyacrylamide gradient gel electrophoresis and staining with periodic acid-Schiff_reagent .
22032939	0	carbohydrate	12,24	transferrin	35,46	carbohydrate	transferrin	CHEBI:16646	7018	Chemical	Gene	Analysis|nmod|START_ENTITY deficient|nsubj|Analysis deficient|dobj|levels levels|amod|END_ENTITY	Analysis of carbohydrate deficient transferrin serum levels during abstinence .
22902807	0	carbohydrate	95,107	transferrin	29,40	carbohydrate	transferrin	CHEBI:16646	7018	Chemical	Gene	moiety|amod|START_ENTITY branching|nmod|moiety due|nmod|branching due|nsubj|bridging bridging|nmod|END_ENTITY	Disialo-trisialo bridging of transferrin is due to increased branching and fucosylation of the carbohydrate moiety .
24885510	0	carbohydrate	26,38	transferrin	49,60	carbohydrate	transferrin	CHEBI:16646	7018	Chemical	Gene	deficient|amod|START_ENTITY sensitivity|nmod|deficient END_ENTITY|nsubj|sensitivity	Diagnostic sensitivity of carbohydrate deficient transferrin in heavy drinkers .
6497065	0	carbohydrate	48,60	transferrin	23,34	carbohydrate	transferrin	CHEBI:16646	100146633(Tax:9796)	Chemical	Gene	moiety|amod|START_ENTITY role|nmod|moiety Heterogeneity|dep|role Heterogeneity|nmod|END_ENTITY	Heterogeneity of horse transferrin : the role of carbohydrate moiety .
7116205	0	carbohydrate	36,48	transferrin	78,89	carbohydrate	transferrin	CHEBI:16646	7018	Chemical	Gene	moiety|amod|START_ENTITY heterogeneity|nmod|moiety heterogeneity|nmod|END_ENTITY	The structural heterogeneity of the carbohydrate moiety of desialylated human transferrin .
856748	0	carbohydrate	25,37	transferrin	62,73	carbohydrate	transferrin	CHEBI:16646	7018	Chemical	Gene	composition|amod|START_ENTITY observations|nmod|composition observations|nmod|END_ENTITY	Some observations on the carbohydrate composition of purified transferrin .
8981095	0	carbohydrate	66,78	transferrin	51,62	carbohydrate	transferrin	CHEBI:16646	7018	Chemical	Gene	deficient_glycoprotein_syndrome_type_I|amod|START_ENTITY END_ENTITY|nmod|deficient_glycoprotein_syndrome_type_I	The identification of abnormal glycoforms of serum transferrin in carbohydrate deficient_glycoprotein_syndrome_type_I by capillary zone electrophoresis .
921736	0	carbohydrate	62,74	transferrin	13,24	carbohydrate	transferrin	CHEBI:16646	280705(Tax:9913)	Chemical	Gene	compositions|amod|START_ENTITY phenotypes|dep|compositions phenotypes|compound|END_ENTITY	Bovine serum transferrin phenotypes AA , D1D1 , D2D2 , EE : their carbohydrate compositions and electrophoretic multiplicity .
9372274	0	carbohydrate	12,24	transferrin	35,46	carbohydrate	transferrin	CHEBI:16646	7018	Chemical	Gene	deficient|amod|START_ENTITY Analysis|nmod|deficient END_ENTITY|nsubj|Analysis	Analysis of carbohydrate deficient transferrin by capillary zone electrophoresis .
9545549	0	carbohydrate	18,30	transferrin	41,52	carbohydrate	transferrin	CHEBI:16646	7018	Chemical	Gene	forms|amod|START_ENTITY forms|compound|END_ENTITY	Identification of carbohydrate deficient transferrin forms by MALDI-TOF mass spectrometry and lectin ELISABiochim Biophys Acta 1998 Aug 24 ; 1381 -LRB- 3 -RRB- :356 .
9579803	0	carbohydrate	118,130	transferrin	86,97	carbohydrate	transferrin	CHEBI:16646	7018	Chemical	Gene	deficient_syndrome_type_II|amod|START_ENTITY patient|nmod|deficient_syndrome_type_II END_ENTITY|nmod|patient	Determination of glycan structures and molecular masses of the glycovariants of serum transferrin from a patient with carbohydrate deficient_syndrome_type_II .
9751792	0	carbohydrate	70,82	transferrin	114,125	carbohydrate	transferrin	CHEBI:16646	7018	Chemical	Gene	moiety|amod|START_ENTITY moiety|nmod|END_ENTITY	Expression of N-linked sialyl_Le -LRB- x -RRB- determinants and O-glycans in the carbohydrate moiety of human amniotic fluid transferrin during pregnancy .
3972840	0	carbohydrate	4,16	uteroferrin	38,49	carbohydrate	uteroferrin	CHEBI:16646	397414(Tax:9823)	Chemical	Gene	structure|amod|START_ENTITY structure|nmod|END_ENTITY	The carbohydrate structure of porcine uteroferrin and the role of the high mannose chains in promoting uptake by the reticuloendothelial cells of the fetal liver .
1520526	0	carbohydrates	35,48	ABH	109,112	carbohydrates	ABH	MESH:D002241	8846	Chemical	Gene	START_ENTITY|nmod|distribution distribution|nmod|END_ENTITY	Basic biochemistry of cell surface carbohydrates and aspects of the tissue distribution of histo-blood group ABH and related glycosphingolipids .
9322794	0	carbohydrates	76,89	Apolipoprotein_A1	0,17	carbohydrates	Apolipoprotein A1	MESH:D002241	25081(Tax:10116)	Chemical	Gene	modulated|nmod|START_ENTITY modulated|nsubjpass|expression expression|amod|END_ENTITY	Apolipoprotein_A1 expression in young and aged rats is modulated by dietary carbohydrates .
10953221	0	carbohydrates	32,45	IgG3	14,18	carbohydrates	IgG3	MESH:D002241	380795(Tax:10090)	Chemical	Gene	responses|nmod|START_ENTITY responses|amod|END_ENTITY	Comparison of IgG3 responses to carbohydrates following mouse infection or immunization with six species of Trichinella .
24361107	0	carbohydrates	12,25	Kupffer_cell_receptor	100,121	carbohydrates	Kupffer cell receptor	MESH:D002241	51811(Tax:10090)	Chemical	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	The surface carbohydrates of the Echinococcus_granulosus larva interact selectively with the rodent Kupffer_cell_receptor .
19067429	0	carbohydrates	75,88	MAdCAM-1	35,43	carbohydrates	MAdCAM-1	MESH:D002241	8174	Chemical	Gene	protein|nmod|START_ENTITY protein|compound|END_ENTITY	GlcNAc6ST-1-mediated decoration of MAdCAM-1 protein with L-selectin ligand carbohydrates directs disease activity of ulcerative_colitis .
9168962	0	carbohydrates	90,103	MG160	28,33	carbohydrates	MG160	MESH:D002241	875275(Tax:243273)	Chemical	Gene	require|dobj|START_ENTITY require|nsubj|END_ENTITY	The Golgi sialoglycoprotein MG160 , expressed in Pichia_pastoris , does not require complex carbohydrates and sialic_acid for secretion and basic fibroblast growth factor binding .
16615351	0	carbohydrates	113,126	Mucin	0,5	carbohydrates	Mucin	MESH:D002241	423101(Tax:9031)	Chemical	Gene	feeding|nmod|START_ENTITY affected|nmod|feeding intestinal|ccomp|affected intestinal|nsubj|expression expression|amod|END_ENTITY	Mucin gene expression and mucin content in the chicken intestinal goblet cells are affected by in ovo feeding of carbohydrates .
7472674	0	carbohydrates	127,140	apo_A-IV	158,166	carbohydrates	apo A-IV	MESH:D002241	25080(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|transport transport|amod|END_ENTITY	Repression of fat-dependent intestinal apo_A-IV mRNA abundance by medium chain triacylglycerols and proteins , and elevation by carbohydrates of fat-dependent apo_A-IV transport in suckling rat pups .
12558975	0	carbohydrates	89,102	basigin	40,47	carbohydrates	basigin	MESH:D002241	12215(Tax:10090)	Chemical	Gene	protein|nmod|START_ENTITY protein|nsubj|END_ENTITY	The immunoglobulin-superfamily molecule basigin is a binding protein for oligomannosidic carbohydrates : an anti-idiotypic approach .
9134052	0	carbohydrates	46,59	glucagon-like_peptide-1	11,34	carbohydrates	glucagon-like peptide-1	MESH:D002241	24952(Tax:10116)	Chemical	Gene	Release|nmod|START_ENTITY Release|nmod|END_ENTITY	Release of glucagon-like_peptide-1 -LRB- GLP-1 -RRB- by carbohydrates in the perfused rat ileum .
18662691	0	carbohydrates	53,66	glucokinase	13,24	carbohydrates	glucokinase	MESH:D002241	430370(Tax:9031)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of glucokinase in chicken liver by dietary carbohydrates .
11584106	0	carbohydrates	12,25	insulin	29,36	carbohydrates	insulin	MESH:D002241	3630	Chemical	Gene	role|nmod|START_ENTITY role|nmod|resistance resistance|compound|END_ENTITY	The role of carbohydrates in insulin resistance .
12575905	0	carbohydrates	75,88	insulin	112,119	carbohydrates	insulin	MESH:D002241	3630	Chemical	Gene	START_ENTITY|nmod|profiles profiles|nmod|fatty_acids fatty_acids|compound|END_ENTITY	A randomised four-intervention crossover study investigating the effect of carbohydrates on daytime profiles of insulin , glucose , non-esterified fatty_acids and triacylglycerols in middle-aged men .
19886515	0	carbohydrates	98,111	insulin	14,21	carbohydrates	insulin	MESH:D002241	3630	Chemical	Gene	subjects|advcl|START_ENTITY subjects|nsubj|Adiponectin Adiponectin|appos|concentrations concentrations|compound|END_ENTITY	-LSB- Adiponectin , insulin and glucose concentrations in overweight and obese subjects after a complex carbohydrates -LRB- fiber -RRB- diet -RSB- .
5328874	0	carbohydrates	45,58	insulin	11,18	carbohydrates	insulin	MESH:D002241	3630	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of insulin on the turnover of plasma carbohydrates and lipids .
6349660	0	carbohydrates	21,34	insulin	85,92	carbohydrates	insulin	MESH:D002241	3630	Chemical	Gene	role|nmod|START_ENTITY -LSB-|dobj|role -LSB-|nmod|determination determination|nmod|requirements requirements|compound|END_ENTITY	-LSB- The role of dietary carbohydrates and proteins in the determination of postprandial insulin requirements , evaluated by artificial pancreas , in type I diabetics -RSB- .
9972287	0	carbohydrates	10,23	insulin	29,36	carbohydrates	insulin	MESH:D002241	3630	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Effect of carbohydrates upon insulin secretion in Bufo arenarum -LRB- Amphibia : Bufonidae -RRB- .
8228387	0	carbohydrates	10,23	interferon-gamma	57,73	carbohydrates	interferon-gamma	MESH:D002241	3458	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of carbohydrates on the pharmacokinetics of human interferon-gamma .
10883504	0	carbohydrates	34,47	mucin	28,33	carbohydrates	mucin	MESH:D002241	100508689	Chemical	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	-LSB- Differential expression of mucin carbohydrates in human endometria -RSB- .
22998734	0	carbohydrates	25,38	mucin	69,74	carbohydrates	mucin	MESH:D002241	100508689	Chemical	Gene	modification|nmod|START_ENTITY unmask|nsubj|modification unmask|dobj|antigens antigens|compound|END_ENTITY	Chemical modification of carbohydrates in tissue sections may unmask mucin antigens .
3030298	0	carbohydrates	8,21	mucin	67,72	carbohydrates	mucin	MESH:D002241	442975(Tax:9615)	Chemical	Gene	START_ENTITY|nmod|viscosity viscosity|nmod|END_ENTITY	Role of carbohydrates in the viscosity and permeability of gastric mucin to hydrogen ion .
9447246	0	carbohydrates	35,48	mucin	29,34	carbohydrates	mucin	MESH:D002241	423101(Tax:9031)	Chemical	Gene	START_ENTITY|nsubj|influence influence|nmod|diet diet|nmod|END_ENTITY	The influence of diet on the mucin carbohydrates in the chick intestinal tract .
8761007	0	carbohydrates	22,35	neurotensin	60,71	carbohydrates	neurotensin	MESH:D002241	299757(Tax:10116)	Chemical	Gene	influence|nmod|START_ENTITY influence|nmod|END_ENTITY	Opposite influence of carbohydrates and fat on hypothalamic neurotensin in Long-Evans rats .
2827574	0	carbohydrates	85,98	ornithine_aminotransferase	48,74	carbohydrates	ornithine aminotransferase	MESH:D002241	64313(Tax:10116)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of cyclic_AMP-dependent induction of ornithine_aminotransferase by simple carbohydrates in cultured hepatocytes .
24893201	0	carbohydrates	58,71	oxytocin	32,40	carbohydrates	oxytocin	MESH:D002241	18429(Tax:10090)	Chemical	Gene	relationship|nmod|START_ENTITY relationship|nmod|END_ENTITY	Functional relationship between oxytocin and appetite for carbohydrates versus saccharin .
15484954	0	carbohydrates	22,35	sodium-dependent_glucose_cotransporter	56,94	carbohydrates	sodium-dependent glucose cotransporter	MESH:D002241	115584	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Influence of abomasal carbohydrates on small intestinal sodium-dependent_glucose_cotransporter activity and abundance in steers .
19119997	0	carboline	23,32	MAPKAP_K2	62,71	carboline	MAPKAP K2	null	9261	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|inhibitors inhibitors|nmod|END_ENTITY	Structural analysis of carboline derivatives as inhibitors of MAPKAP_K2 using 3D QSAR and docking studies .
23601885	0	carbon	57,63	C-reactive_protein	29,47	carbon	C-reactive protein	MESH:D002244	1401	Chemical	Gene	based|nmod|START_ENTITY END_ENTITY|acl|based	Disposable immunosensors for C-reactive_protein based on carbon nanotubes field effect transistors .
10073931	0	carbon	181,187	CO2	32,35	carbon	CO2	MESH:D002244	717	Chemical	Gene	cycle|compound|START_ENTITY reconstruction|nmod|cycle archive|nmod|reconstruction constitutes|dobj|archive constitutes|nsubj|records records|nmod|END_ENTITY	Ice core records of atmospheric CO2 around the last three glacial terminations Air trapped in bubbles in polar ice cores constitutes an archive for the reconstruction of the global carbon cycle and the relation between greenhouse gases and climate in the past .
10737411	0	carbon	48,54	CO2	112,115	carbon	CO2	MESH:D002244	717	Chemical	Gene	demand|nmod|START_ENTITY demand|dep|use use|nmod|END_ENTITY	Meeting the photosynthetic demand for inorganic carbon in an alga-invertebrate association : preferential use of CO2 by symbionts in the giant clam Tridacna gigas .
10938841	0	carbon	271,277	CO2	98,101	carbon	CO2	MESH:D002244	717	Chemical	Gene	assimilation|compound|START_ENTITY control|nmod|assimilation study|dobj|control used|xcomp|study used|nsubjpass|Control Control|dep|effects effects|nmod|activities activities|nmod|mutants mutants|amod|phosphoenolpyruvate_carboxylase phosphoenolpyruvate_carboxylase|nmod|assimilation assimilation|nummod|END_ENTITY	Control of C4 photosynthesis : effects of reduced activities of phosphoenolpyruvate_carboxylase on CO2 assimilation in Amaranthus edulis L. Heterozygous mutants of Amaranthus_edulis_deficient in PEP_carboxylase -LRB- PEPC -RRB- have been used to study the control of photosynthetic carbon assimilation .
10984048	0	carbon	126,132	CO2	25,28	carbon	CO2	MESH:D002244	717	Chemical	Gene	sequestration|nmod|START_ENTITY reversed|nsubjpass|sequestration Acclimation|dep|reversed Acclimation|nmod|exchange exchange|compound|END_ENTITY	Acclimation of ecosystem CO2 exchange in the Alaskan Arctic in response to decadal climate warming Long-term sequestration of carbon in Alaskan Arctic tundra ecosystems was reversed by warming and drying of the climate in the early 1980s , resulting in substantial losses of terrestrial carbon .
10984048	0	carbon	286,292	CO2	25,28	carbon	CO2	MESH:D002244	717	Chemical	Gene	Acclimation|nmod|START_ENTITY Acclimation|nmod|exchange exchange|compound|END_ENTITY	Acclimation of ecosystem CO2 exchange in the Alaskan Arctic in response to decadal climate warming Long-term sequestration of carbon in Alaskan Arctic tundra ecosystems was reversed by warming and drying of the climate in the early 1980s , resulting in substantial losses of terrestrial carbon .
11373676	0	carbon	8,14	CO2	99,102	carbon	CO2	MESH:D002244	717	Chemical	Gene	storage|compound|START_ENTITY storage|nmod|END_ENTITY	Limited carbon storage in soil and litter of experimental forest plots under increased atmospheric CO2 .
11536468	0	carbon	2,8	CO2	27,30	carbon	CO2	MESH:D002244	717	Chemical	Gene	isotope|nsubj|START_ENTITY isotope|dobj|record record|nmod|levels levels|nummod|END_ENTITY	A carbon isotope record of CO2 levels during the late Quaternary .
11537848	0	carbon	17,23	CO2	75,78	carbon	CO2	MESH:D002244	717	Chemical	Gene	Fractionation|nmod|START_ENTITY isotopes|nsubj|Fractionation isotopes|nmod|phytoplankton phytoplankton|nmod|levels levels|compound|END_ENTITY	Fractionation of carbon isotopes by phytoplankton and estimates of ancient CO2 levels .
11758430	0	carbon	128,134	CO2	35,38	carbon	CO2	MESH:D002244	717	Chemical	Gene	cycle|compound|START_ENTITY process|nmod|cycle partition|nmod|process partition|nsubj|Influence Influence|nmod|concentration concentration|compound|END_ENTITY	-LSB- Influence of elevated atmospheric CO2 concentration on photosynthesis and leaf nitrogen partition in process of photosynthetic carbon cycle in Musa paradisiaca -RSB- .
12180260	0	carbon	91,97	CO2	9,12	carbon	CO2	MESH:D002244	717	Chemical	Gene	source|nmod|START_ENTITY use|nmod|source fermentations|acl:relcl|use monitor|dobj|fermentations electrode|xcomp|monitor electrode|nsubj|Use Use|nmod|END_ENTITY	Use of a CO2 electrode to monitor fermentations that use xenobiotic compounds as source of carbon .
12812251	0	carbon	47,53	CO2	23,26	carbon	CO2	MESH:D002244	717	Chemical	Gene	ratio|compound|START_ENTITY conductance|nmod|ratio conductance|nsubj|effect effect|nmod|END_ENTITY	The effect of internal CO2 conductance on leaf carbon isotope ratio .
12952786	0	carbon	8,14	CO2	37,40	carbon	CO2	MESH:D002244	717	Chemical	Gene	uptake|nsubj|START_ENTITY uptake|nmod|spring spring|compound|END_ENTITY	Tracing carbon uptake from a natural CO2 spring into tree rings : an isotope approach .
14558905	0	carbon	18,24	CO2	100,103	carbon	CO2	MESH:D002244	717	Chemical	Gene	cycle|compound|START_ENTITY future|nmod|cycle future|dep|review review|acl|calcification calcification|nmod|END_ENTITY	The future of the carbon cycle : review , calcification response , ballast and feedback on atmospheric CO2 .
14562937	0	carbon	47,53	CO2	5,8	carbon	CO2	MESH:D002244	717	Chemical	Gene	flux|nmod|START_ENTITY flux|nsubj|END_ENTITY	Soil CO2 flux in relation to dissolved organic carbon , soil temperature and moisture in a subtropical arable soil of China .
14689297	0	carbon	39,45	CO2	65,68	carbon	CO2	MESH:D002244	717	Chemical	Gene	subsidies|compound|START_ENTITY increase|nsubj|subsidies increase|dobj|flux flux|compound|END_ENTITY	Experimental evidence that terrestrial carbon subsidies increase CO2 flux from lake ecosystems .
15267411	0	carbon	54,60	CO2	33,36	carbon	CO2	MESH:D002244	717	Chemical	Gene	nanotubes|compound|START_ENTITY behavior|nmod|nanotubes behavior|nmod|END_ENTITY	Vibrational behavior of adsorbed CO2 on single-walled carbon nanotubes .
15491194	0	carbon	58,64	CO2	51,54	carbon	CO2	MESH:D002244	717	Chemical	Gene	slit|compound|START_ENTITY END_ENTITY|nmod|slit	High-pressure adsorption capacity and structure of CO2 in carbon slit pores : theory and simulation .
15574404	0	carbon	87,93	CO2	31,34	carbon	CO2	MESH:D002244	717	Chemical	Gene	uptake|compound|START_ENTITY coupling|nmod|uptake reveals|dobj|coupling reveals|nsubj|increase increase|nmod|concentration concentration|compound|END_ENTITY	Sudden increase in atmospheric CO2 concentration reveals strong coupling between shoot carbon uptake and root nutrient uptake in young walnut trees .
16091970	0	carbon	116,122	CO2	37,40	carbon	CO2	MESH:D002244	717	Chemical	Gene	sink|compound|START_ENTITY springtime|dobj|sink influences|xcomp|springtime influences|nmod|exchange exchange|compound|END_ENTITY	Climatic influences on net ecosystem CO2 exchange during the transition from wintertime carbon source to springtime carbon sink in a high-elevation , subalpine forest .
16091970	0	carbon	88,94	CO2	37,40	carbon	CO2	MESH:D002244	717	Chemical	Gene	source|compound|START_ENTITY transition|nmod|source exchange|nmod|transition exchange|compound|END_ENTITY	Climatic influences on net ecosystem CO2 exchange during the transition from wintertime carbon source to springtime carbon sink in a high-elevation , subalpine forest .
16105807	0	carbon	4,10	CO2	82,85	carbon	CO2	MESH:D002244	717	Chemical	Gene	storage|compound|START_ENTITY storage|nmod|years years|nmod|enrichment enrichment|compound|END_ENTITY	Net carbon storage in a poplar plantation -LRB- POPFACE -RRB- after three years of free-air CO2 enrichment .
16151007	0	carbon	66,72	CO2	19,22	carbon	CO2	MESH:D002244	717	Chemical	Gene	sequestration|nmod|START_ENTITY reduces|dobj|sequestration reduces|nsubj|END_ENTITY	Rising atmospheric CO2 reduces sequestration of root-derived soil carbon .
16191765	0	carbon	17,23	CO2	41,44	carbon	CO2	MESH:D002244	717	Chemical	Gene	Incorporation|nmod|START_ENTITY Incorporation|acl|originating originating|nmod|END_ENTITY	Incorporation of carbon originating from CO2 into different compounds of soil microbial biomass and soil organic matter .
16201660	0	carbon	66,72	CO2	42,45	carbon	CO2	MESH:D002244	717	Chemical	Gene	sequestration|compound|START_ENTITY particles|nmod|sequestration particles|compound|END_ENTITY	Field studies on the formation of sinking CO2 particles for ocean carbon sequestration : effects of injector geometry on particle density and dissolution rate and model simulation of plume behavior .
16634296	0	carbon	45,51	CO2	9,12	carbon	CO2	MESH:D002244	717	Chemical	Gene	accumulations|nmod|START_ENTITY stimulates|dobj|accumulations stimulates|nsubj|END_ENTITY	Elevated CO2 stimulates net accumulations of carbon and nitrogen in land ecosystems : a meta-analysis .
16930461	0	carbon	50,56	CO2	28,31	carbon	CO2	MESH:D002244	717	Chemical	Gene	accounts|compound|START_ENTITY sink|nmod|accounts sink|nsubj|Significance Significance|nmod|END_ENTITY	Significance of the oceanic CO2 sink for national carbon accounts .
16995919	0	carbon	71,77	CO2	7,10	carbon	CO2	MESH:D002244	717	Chemical	Gene	fate|nmod|START_ENTITY tracing|dobj|fate permits|xcomp|tracing permits|nsubj|enrichment enrichment|compound|END_ENTITY	Canopy CO2 enrichment permits tracing the fate of recently assimilated carbon in a mature deciduous forest .
17348086	0	carbon	41,47	CO2	74,77	carbon	CO2	MESH:D002244	717	Chemical	Gene	Evaluating|nmod|START_ENTITY isotope|csubj|Evaluating isotope|dobj|ratio ratio|nmod|END_ENTITY	Evaluating high time-resolved changes in carbon isotope ratio of respired CO2 by a rapid in-tube incubation technique .
17360605	0	carbon	75,81	CO2	29,32	carbon	CO2	MESH:D002244	717	Chemical	Gene	content|compound|START_ENTITY estimate|nmod|content estimate|nmod|inventory inventory|compound|END_ENTITY	An estimate of anthropogenic CO2 inventory from decadal changes in oceanic carbon content .
17450865	0	carbon	43,49	CO2	89,92	carbon	CO2	MESH:D002244	717	Chemical	Gene	nanotubes|compound|START_ENTITY nanocomposites|nmod|nanotubes synthesized|nsubj|nanocomposites synthesized|nmod|END_ENTITY	Polymeric nanocomposites of functionalized carbon nanotubes synthesized in supercritical CO2 .
17588927	0	carbon	39,45	CO2	91,94	carbon	CO2	MESH:D002244	717	Chemical	Gene	uptake|compound|START_ENTITY Weak|dobj|uptake Weak|nmod|profiles profiles|nmod|END_ENTITY	Weak northern and strong tropical land carbon uptake from vertical profiles of atmospheric CO2 .
17633034	0	carbon	67,73	CO2	25,28	carbon	CO2	MESH:D002244	717	Chemical	Gene	uptake|nmod|START_ENTITY account|nmod|uptake rising|xcomp|account rising|dobj|END_ENTITY	The potential for rising CO2 to account for the observed uptake of carbon by tropical , temperate , and boreal forest biomes .
17669727	0	carbon	30,36	CO2	79,82	carbon	CO2	MESH:D002244	717	Chemical	Gene	composition|compound|START_ENTITY composition|nmod|END_ENTITY	Environmental controls on the carbon isotope composition of ecosystem-respired CO2 in contrasting forest ecosystems in Canada and the USA .
17976229	0	carbon	67,73	CO2	13,16	carbon	CO2	MESH:D002244	717	Chemical	Gene	management|compound|START_ENTITY implications|nmod|management Estimates|dep|implications Estimates|nmod|END_ENTITY	Estimates of CO2 from fires in the United States : implications for carbon management .
17994008	0	carbon	20,26	CO2	49,52	carbon	CO2	MESH:D002244	717	Chemical	Gene	consumption|compound|START_ENTITY Enhanced|dobj|consumption Enhanced|nmod|ocean ocean|compound|END_ENTITY	Enhanced biological carbon consumption in a high CO2 ocean .
18320540	0	carbon	21,27	CO2	66,69	carbon	CO2	MESH:D002244	717	Chemical	Gene	composition|compound|START_ENTITY composition|nmod|END_ENTITY	Assessing the stable carbon isotopic composition of intercellular CO2 in a CAM plant using gas chromatography-combustion-isotope ratio mass spectrometry .
18409651	0	carbon	42,48	CO2	14,17	carbon	CO2	MESH:D002244	717	Chemical	Gene	desorption|nmod|START_ENTITY desorption|compound|END_ENTITY	Supercritical CO2 desorption of activated carbon loaded with 2,2,3,3-tetrafluoro-1-propanol in a rotating packed bed .
18537885	0	carbon	25,31	CO2	0,3	carbon	CO2	MESH:D002244	717	Chemical	Gene	input|compound|START_ENTITY increases|dobj|input increases|nsubj|enrichment enrichment|compound|END_ENTITY	CO2 enrichment increases carbon and nitrogen input from fine roots in a deciduous forest .
18622437	0	carbon	13,19	CO2	0,3	carbon	CO2	MESH:D002244	717	Chemical	Gene	synthesis|compound|START_ENTITY enhanced|dobj|synthesis enhanced|nsubj|END_ENTITY	CO2 enhanced carbon nanotube synthesis from pyrolysis of hydrocarbons .
19201012	0	carbon	45,51	CO2	11,14	carbon	CO2	MESH:D002244	717	Chemical	Gene	nanotubes|compound|START_ENTITY Capture|nmod|nanotubes Capture|nmod|END_ENTITY	Capture of CO2 from flue gas via multiwalled carbon nanotubes .
19383098	0	carbon	78,84	CO2	156,159	carbon	CO2	MESH:D002244	717	Chemical	Gene	rates|compound|START_ENTITY having|dobj|rates having|nmod|-RSB- -RSB-|compound|END_ENTITY	Transcriptomic comparison in the leaves of two aspen genotypes having similar carbon assimilation rates but different partitioning patterns under elevated -LSB- CO2 -RSB- .
19398156	0	carbon	24,30	CO2	77,80	carbon	CO2	MESH:D002244	717	Chemical	Gene	Production|nmod|START_ENTITY thermochemical|nsubj|Production thermochemical|nmod|END_ENTITY	Production of activated carbon by waste tire thermochemical degradation with CO2 .
19401412	0	carbon	30,36	CO2	9,12	carbon	CO2	MESH:D002244	717	Chemical	Gene	effects|nmod|START_ENTITY effects|compound|END_ENTITY	Elevated CO2 effects on plant carbon , nitrogen , and water relations : six important lessons from FACE .
19415342	0	carbon	42,48	CO2	116,119	carbon	CO2	MESH:D002244	717	Chemical	Gene	involved|nmod|START_ENTITY genes|acl|involved Expression|nmod|genes Expression|acl|exposed exposed|nmod|enrichment enrichment|amod|END_ENTITY	Expression of genes involved in symbiotic carbon and nitrogen transport in Pinus taeda mycorrhizal roots exposed to CO2 enrichment and nitrogen fertilization .
19559600	0	carbon	108,114	CO2	36,39	carbon	CO2	MESH:D002244	717	Chemical	Gene	presence|nmod|START_ENTITY production|nmod|presence production|nmod|alga alga|amod|END_ENTITY	Fatty_acid production from a highly CO2 tolerant alga , Chlorocuccum littorale , in the presence of inorganic carbon and nitrate .
19655780	0	carbon	65,71	CO2	113,116	carbon	CO2	MESH:D002244	717	Chemical	Gene	nanofibers|compound|START_ENTITY synthesis|nmod|nanofibers catalysts|nmod|synthesis catalysts|nmod|hydrogenation hydrogenation|nmod|END_ENTITY	Effects of potassium on Ni-K/Al2O3 catalysts in the synthesis of carbon nanofibers by catalytic hydrogenation of CO2 .
19843305	0	carbon	40,46	CO2	74,77	carbon	CO2	MESH:D002244	717	Chemical	Gene	allocation|nmod|START_ENTITY effects|nmod|allocation leaves|nsubj|effects leaves|nmod|efflux efflux|compound|END_ENTITY	Drought effects on allocation of recent carbon : from beech leaves to soil CO2 efflux .
19891428	0	carbon	63,69	CO2	46,49	carbon	CO2	MESH:D002244	717	Chemical	Gene	oxidation|compound|START_ENTITY sites|nmod|oxidation sites|nmod|formation formation|compound|END_ENTITY	Active sites in graphene and the mechanism of CO2 formation in carbon oxidation .
19943684	0	carbon	9,15	CO2	0,3	carbon	CO2	MESH:D002244	717	Chemical	Gene	source|compound|START_ENTITY END_ENTITY|nmod|source	CO2 as a carbon neutral fuel source via enhanced biomass gasification .
19999994	0	carbon	80,86	CO2	20,23	carbon	CO2	MESH:D002244	717	Chemical	Gene	concentration|nmod|START_ENTITY concentration|compound|END_ENTITY	Effects of elevated CO2 concentration and nitrogen supply on biomass and active carbon of freshwater marsh after two growing seasons in Sanjiang Plain , Northeast China .
20185144	0	carbon	84,90	CO2	39,42	carbon	CO2	MESH:D002244	717	Chemical	Gene	ordered|dobj|START_ENTITY ordered|nsubj|equilibrium equilibrium|nmod|END_ENTITY	Adsorption equilibrium and kinetics of CO2 , CH4 , N2O , and NH3 on ordered mesoporous carbon .
20493626	0	carbon	88,94	CO2	46,49	carbon	CO2	MESH:D002244	717	Chemical	Gene	credits|compound|START_ENTITY reduction|nmod|credits emissions|dep|reduction emissions|nummod|END_ENTITY	Cement replacement by sugar cane bagasse ash : CO2 emissions reduction and potential for carbon credits .
20534474	0	carbon	9,15	CO2	106,109	carbon	CO2	MESH:D002244	717	Chemical	Gene	flow|compound|START_ENTITY flow|acl|elevated elevated|dobj|END_ENTITY	Shifting carbon flow from roots into associated microbial communities in response to elevated atmospheric CO2 .
20937899	0	carbon	12,18	CO2	60,63	carbon	CO2	MESH:D002244	717	Chemical	Gene	sinks|nsubj|START_ENTITY sinks|nmod|sampling sampling|compound|END_ENTITY	Regional US carbon sinks from three-dimensional atmospheric CO2 sampling .
21047100	0	carbon	154,160	CO2	25,28	carbon	CO2	MESH:D002244	717	Chemical	Gene	nanotubes|compound|START_ENTITY confined|nmod|nanotubes sorption|nmod|confined sorption|nsubj|simulations simulations|nmod|END_ENTITY	Molecular simulations of CO2 and H2 sorption into ionic liquid 1-n-hexyl-3-methylimidazolium_bis -LRB- trifluoromethylsulfonyl -RRB- amide -LRB- -LSB- hmim -RSB- -LSB- Tf2N -RSB- -RRB- confined in carbon nanotubes .
21132180	0	carbon	33,39	CO2	102,105	carbon	CO2	MESH:D002244	717	Chemical	Gene	generation|nmod|START_ENTITY supported|nsubj|generation supported|xcomp|capture capture|dep|capable capable|nmod|END_ENTITY	One-pot generation of mesoporous carbon supported nanocrystalline calcium_oxides capable of efficient CO2 capture over a wide range of temperatures .
21142064	0	carbon	18,24	CO2	0,3	carbon	CO2	MESH:D002244	717	Chemical	Gene	models|compound|START_ENTITY adsorption|nmod|models adsorption|nsubj|END_ENTITY	CO2 adsorption on carbon models of organic constituents of gas shale and coal .
21152662	0	carbon	33,39	CO2	0,3	carbon	CO2	MESH:D002244	717	Chemical	Gene	nanotubes|compound|START_ENTITY adsorption|nmod|nanotubes adsorption|nummod|END_ENTITY	CO2 adsorption by nitrogen-doped carbon nanotubes predicted by density-functional theory with dispersion-correcting potentials .
21158440	0	carbon	51,57	CO2	90,93	carbon	CO2	MESH:D002244	717	Chemical	Gene	microspheres|compound|START_ENTITY microspheres|nmod|system system|compound|END_ENTITY	Converting poly -LRB- ethylene_terephthalate -RRB- waste into carbon microspheres in a supercritical CO2 system .
21231935	0	carbon	38,44	CO2	79,82	carbon	CO2	MESH:D002244	717	Chemical	Gene	transfer|compound|START_ENTITY velocity|nmod|transfer assessment|nmod|velocity END_ENTITY|nmod|assessment	In situ assessment of the velocity of carbon transfer by tracing 13 C in trunk CO2 efflux after pulse labelling : variations among tree species and seasons .
21329201	0	carbon	78,84	CO2	44,47	carbon	CO2	MESH:D002244	717	Chemical	Gene	incineration|compound|START_ENTITY sinks|nmod|incineration sinks|nummod|END_ENTITY	Estuarine and coastal ocean carbon paradox : CO2 sinks or sites of terrestrial carbon incineration ?
21359551	0	carbon	10,16	CO2	52,55	carbon	CO2	MESH:D002244	717	Chemical	Gene	transporters|compound|START_ENTITY transporters|nmod|END_ENTITY	Inorganic carbon transporters of the cyanobacterial CO2 concentrating mechanism .
21389405	0	carbon	17,23	CO2	102,105	carbon	CO2	MESH:D002244	717	Chemical	Gene	influence|nmod|START_ENTITY surface|nsubj|influence surface|nmod|parameters parameters|acl|calculated calculated|nmod|isotherm isotherm|compound|END_ENTITY	The influence of carbon surface oxygen groups on Dubinin-Astakhov equation parameters calculated from CO2 adsorption isotherm .
21548280	0	carbon	53,59	CO2	1,4	carbon	CO2	MESH:D002244	717	Chemical	Gene	budget|compound|START_ENTITY flux|nmod|budget flux|nsubj|END_ENTITY	-LSB- CO2 flux characteristics and their influence on the carbon budget of a larch plantation in Maoershan region of Northeast China -RSB- .
21594294	0	carbon	37,43	CO2	10,13	carbon	CO2	MESH:D002244	717	Chemical	Gene	sieves|compound|START_ENTITY adsorption|nmod|sieves adsorption|nsubj|END_ENTITY	Ultrahigh CO2 adsorption capacity on carbon molecular sieves at room temperature .
21644559	0	carbon	92,98	CO2	53,56	carbon	CO2	MESH:D002244	717	Chemical	Gene	nanotubes|compound|START_ENTITY END_ENTITY|nmod|nanotubes	Adsorption , desorption , and thermodynamic studies of CO2 with high-amine-loaded multiwalled carbon nanotubes .
21740048	0	carbon	16,22	CO2	64,67	carbon	CO2	MESH:D002244	717	Chemical	Gene	Deployment|nmod|START_ENTITY isotope|nsubj|Deployment isotope|dobj|ratiometer ratiometer|nmod|monitoring monitoring|nmod|leakage leakage|compound|END_ENTITY	Deployment of a carbon isotope ratiometer for the monitoring of CO2 sequestration leakage .
21770463	0	carbon	54,60	CO2	87,90	carbon	CO2	MESH:D002244	717	Chemical	Gene	colloids|compound|START_ENTITY encrusted|dobj|colloids encrusted|nmod|END_ENTITY	Complete synthesis of germanium nanocrystal encrusted carbon colloids in supercritical CO2 and their superhydrophobic properties .
21822505	0	carbon	12,18	CO2	40,43	carbon	CO2	MESH:D002244	717	Chemical	Gene	adsorbents|compound|START_ENTITY adsorbents|nmod|END_ENTITY	Microporous carbon adsorbents with high CO2 capacities for industrial applications .
21848329	0	carbon	52,58	CO2	24,27	carbon	CO2	MESH:D002244	717	Chemical	Gene	adsorption|nmod|START_ENTITY adsorption|nsubj|analysis analysis|nmod|END_ENTITY	Gravimetric analysis of CO2 adsorption on activated carbon at various pressures and temperatures using piezoelectric microcantilevers .
22091700	0	carbon	49,55	CO2	77,80	carbon	CO2	MESH:D002244	717	Chemical	Gene	composites|compound|START_ENTITY composites|nmod|END_ENTITY	In situ synthesis of polymer-modified mesoporous carbon CMK-3 composites for CO2 sequestration .
22117227	0	carbon	40,46	CO2	17,20	carbon	CO2	MESH:D002244	717	Chemical	Gene	capture|nmod|START_ENTITY capture|compound|END_ENTITY	Highly selective CO2 capture on N-doped carbon produced by chemical activation of polypyrrole functionalized graphene sheets .
22243844	0	carbon	42,48	CO2	23,26	carbon	CO2	MESH:D002244	717	Chemical	Gene	site|compound|START_ENTITY release|nmod|site release|nsubj|influence influence|nmod|END_ENTITY	Potential influence of CO2 release from a carbon capture storage site on release of trace metals from marine sediment .
22258017	0	carbon	24,30	CO2	17,20	carbon	CO2	MESH:D002244	717	Chemical	Gene	Decomposition|nmod|START_ENTITY Decomposition|nmod|END_ENTITY	Decomposition of CO2 to carbon and oxygen under mild conditions over a zinc-modified zeolite .
22384238	0	carbon	24,30	CO2	117,120	carbon	CO2	MESH:D002244	717	Chemical	Gene	sources|compound|START_ENTITY Contribution|nmod|sources mediated|nsubj|Contribution mediated|nmod|concentrations concentrations|compound|END_ENTITY	Contribution of various carbon sources toward isoprene biosynthesis in poplar leaves mediated by altered atmospheric CO2 concentrations .
22443472	0	carbon	37,43	CO2	20,23	carbon	CO2	MESH:D002244	717	Chemical	Gene	capture|compound|START_ENTITY leakage|nmod|capture leakage|nsubj|impact impact|nmod|END_ENTITY	Potential impact of CO2 leakage from carbon capture and storage systems on field bean -LRB- Vicia faba -RRB- .
22619940	0	carbon	67,73	CO2	32,35	carbon	CO2	MESH:D002244	717	Chemical	Gene	source|compound|START_ENTITY concentration|nmod|source concentration|compound|END_ENTITY	-LSB- Characteristics of atmospheric CO2 concentration and variation of carbon source _ sink at Lin ` an regional background station -RSB- .
22675123	0	carbon	105,111	CO2	26,29	carbon	CO2	MESH:D002244	717	Chemical	Gene	seesaw|compound|START_ENTITY associated|nmod|seesaw associated|nsubj|change change|nmod|variability variability|compound|END_ENTITY	Mode change of millennial CO2 variability during the last glacial cycle associated with a bipolar marine carbon seesaw .
22679919	0	carbon	25,31	CO2	0,3	carbon	CO2	MESH:D002244	717	Chemical	Gene	materials|compound|START_ENTITY capture|nmod|materials capture|nsubj|END_ENTITY	CO2 capture in different carbon materials .
22717067	0	carbon	65,71	CO2	76,79	carbon	CO2	MESH:D002244	717	Chemical	Gene	START_ENTITY|nmod|capture capture|compound|END_ENTITY	Sustainable and hierarchical porous Enteromorpha prolifera based carbon for CO2 capture .
22747244	0	carbon	50,56	CO2	32,35	carbon	CO2	MESH:D002244	717	Chemical	Gene	compounds|compound|START_ENTITY adsorption|nmod|compounds adsorption|nsubj|studies studies|nmod|END_ENTITY	Molecular simulation studies of CO2 adsorption by carbon model compounds for carbon capture and sequestration applications .
22747244	0	carbon	77,83	CO2	32,35	carbon	CO2	MESH:D002244	717	Chemical	Gene	capture|compound|START_ENTITY compounds|nmod|capture adsorption|nmod|compounds adsorption|nsubj|studies studies|nmod|END_ENTITY	Molecular simulation studies of CO2 adsorption by carbon model compounds for carbon capture and sequestration applications .
22776588	0	carbon	27,33	CO2	86,89	carbon	CO2	MESH:D002244	717	Chemical	Gene	cycling|compound|START_ENTITY accelerate|dobj|cycling accelerate|nmod|forests forests|acl|exposed exposed|nmod|END_ENTITY	Roots and fungi accelerate carbon and nitrogen cycling in forests exposed to elevated CO2 .
22781368	0	carbon	41,47	CO2	83,86	carbon	CO2	MESH:D002244	717	Chemical	Gene	nanotubes|compound|START_ENTITY wrapped|dobj|nanotubes Poly|acl|wrapped Poly|nmod|END_ENTITY	Poly -LRB- ionic liquid -RRB- - wrapped single-walled carbon nanotubes for sub-ppb detection of CO2 .
22911327	0	carbon	62,68	CO2	14,17	carbon	CO2	MESH:D002244	717	Chemical	Gene	monoliths|compound|START_ENTITY uptake|nmod|monoliths uptake|nsubj|END_ENTITY	Unprecedented CO2 uptake over highly porous N-doped activated carbon monoliths prepared by physical activation .
22936776	0	carbon	46,52	CO2	82,85	carbon	CO2	MESH:D002244	717	Chemical	Gene	decomposition|compound|START_ENTITY increase|dobj|decomposition increase|nmod|END_ENTITY	Arbuscular mycorrhizal fungi increase organic carbon decomposition under elevated CO2 .
23046640	0	carbon	80,86	CO2	52,55	carbon	CO2	MESH:D002244	717	Chemical	Gene	fibers|compound|START_ENTITY adsorption|nmod|fibers adsorption|compound|END_ENTITY	Determination of the optimal pore size for improved CO2 adsorption in activated carbon fibers .
23092110	0	carbon	35,41	CO2	15,18	carbon	CO2	MESH:D002244	717	Chemical	Gene	sequestration|compound|START_ENTITY diffusivity|nmod|sequestration diffusivity|nummod|END_ENTITY	Measurement of CO2 diffusivity for carbon sequestration : a microfluidic approach for reservoir-specific analysis .
23140278	0	carbon	105,111	CO2	133,136	carbon	CO2	MESH:D002244	717	Chemical	Gene	sequestration|compound|START_ENTITY produced|nmod|sequestration produced|parataxis|trapping trapping|nsubj|END_ENTITY	Permeability reduction produced by grain reorganization and accumulation of exsolved CO2 during geologic carbon sequestration : a new CO2 trapping mechanism .
23140278	0	carbon	105,111	CO2	85,88	carbon	CO2	MESH:D002244	717	Chemical	Gene	sequestration|compound|START_ENTITY produced|nmod|sequestration produced|nmod|reorganization reorganization|nmod|END_ENTITY	Permeability reduction produced by grain reorganization and accumulation of exsolved CO2 during geologic carbon sequestration : a new CO2 trapping mechanism .
23398600	0	carbon	10,16	CO2	29,32	carbon	CO2	MESH:D002244	717	Chemical	Gene	spheres|nsubj|START_ENTITY spheres|nmod|adsorption adsorption|compound|END_ENTITY	Activated carbon spheres for CO2 adsorption .
23401500	0	carbon	73,79	CO2	40,43	carbon	CO2	MESH:D002244	717	Chemical	Gene	stimulates|nmod|START_ENTITY stimulates|dobj|release release|compound|END_ENTITY	Surface exposure to sunlight stimulates CO2 release from permafrost soil carbon in the Arctic .
23425486	0	carbon	38,44	CO2	79,82	carbon	CO2	MESH:D002244	717	Chemical	Gene	micropores|compound|START_ENTITY predictions|nmod|micropores predictions|nmod|transport transport|compound|END_ENTITY	Slippage and viscosity predictions in carbon micropores and their influence on CO2 and CH4 transport .
23433521	0	carbon	21,27	CO2	67,70	carbon	CO2	MESH:D002244	717	Chemical	Gene	size|compound|START_ENTITY size|nmod|END_ENTITY	Synergetic effect of carbon nanopore size and surface oxidation on CO2 capture from CO2/CH4 mixtures .
23500788	0	carbon	48,54	CO2	0,3	carbon	CO2	MESH:D002244	717	Chemical	Gene	modified|dobj|START_ENTITY adsorption|advcl|modified adsorption|nsubj|END_ENTITY	CO2 adsorption on chemically modified activated carbon .
23504797	0	carbon	62,68	CO2	43,46	carbon	CO2	MESH:D002244	717	Chemical	Gene	flow|compound|START_ENTITY Impacts|nmod|flow Impacts|nmod|years years|nmod|END_ENTITY	Impacts of 3 years of elevated atmospheric CO2 on rhizosphere carbon flow and microbial community dynamics .
23617579	0	carbon	56,62	CO2	81,84	carbon	CO2	MESH:D002244	717	Chemical	Gene	START_ENTITY|nmod|capture capture|compound|END_ENTITY	Predicting mixed-gas adsorption equilibria on activated carbon for precombustion CO2 capture .
23658109	0	carbon	59,65	CO2	80,83	carbon	CO2	MESH:D002244	717	Chemical	Gene	materials|compound|START_ENTITY Functional|dobj|materials Functional|nmod|capture capture|compound|END_ENTITY	Functional zeolitic-imidazolate-framework-templated porous carbon materials for CO2 capture and enhanced capacitors .
23865980	1	carbon	167,173	CO2	250,253	carbon	CO2	MESH:D002244	717	Chemical	Gene	atom|compound|START_ENTITY electronegativity|nmod|atom N-Heterocyclic_Olefin|nmod|electronegativity found|nsubjpass|N-Heterocyclic_Olefin found|xcomp|show show|advcl|affording affording|dobj|adduct adduct|compound|END_ENTITY	N-Heterocyclic_Olefin -LRB- NHO -RRB- with high electronegativity at the terminal carbon atom was found to show a strong tendency for CO2 sequestration , affording a CO2 adduct -LRB- NHO-CO2 -RRB- .
23895233	0	carbon	11,17	CO2	126,129	carbon	CO2	MESH:D002244	717	Chemical	Gene	stabilized|nsubj|START_ENTITY stabilized|ccomp|synthesized synthesized|nmod|capture capture|compound|END_ENTITY	Mesoporous carbon stabilized MgO nanoparticles synthesized by pyrolysis of MgCl2 preloaded waste biomass for highly efficient CO2 capture .
23897802	0	carbon	13,19	CO2	75,78	carbon	CO2	MESH:D002244	717	Chemical	Gene	emission|compound|START_ENTITY emission|dep|source source|nmod|END_ENTITY	Soil organic carbon dust emission : an omitted global source of atmospheric CO2 .
23953054	0	carbon	86,92	CO2	33,36	carbon	CO2	MESH:D002244	717	Chemical	Gene	cycle|compound|START_ENTITY amplification|nmod|cycle due|nmod|amplification due|nmod:npmod|sources sources|nummod|END_ENTITY	Tundra ecosystems observed to be CO2 sources due to differential amplification of the carbon cycle .
24033081	0	carbon	63,69	CO2	99,102	carbon	CO2	MESH:D002244	717	Chemical	Gene	fertilization|compound|START_ENTITY fertilization|nmod|END_ENTITY	Invasive forb benefits from water savings by native plants and carbon fertilization under elevated CO2 and warming .
24056579	0	carbon	116,122	CO2	147,150	carbon	CO2	MESH:D002244	717	Chemical	Gene	source|compound|START_ENTITY source|nmod|uptake uptake|compound|END_ENTITY	A new microporous carbon material synthesized via thermolysis of a porous aromatic framework embedded with an extra carbon source for low-pressure CO2 uptake .
24056579	0	carbon	18,24	CO2	147,150	carbon	CO2	MESH:D002244	717	Chemical	Gene	material|compound|START_ENTITY synthesized|nsubj|material synthesized|nmod|thermolysis thermolysis|nmod|framework framework|acl|embedded embedded|nmod|source source|nmod|uptake uptake|compound|END_ENTITY	A new microporous carbon material synthesized via thermolysis of a porous aromatic framework embedded with an extra carbon source for low-pressure CO2 uptake .
24101972	0	carbon	80,86	CO2	30,33	carbon	CO2	MESH:D002244	717	Chemical	Gene	gain|compound|START_ENTITY modify|dobj|gain modify|nsubj|elevations elevations|nmod|END_ENTITY	Do elevations in temperature , CO2 , and nutrient availability modify belowground carbon gain and root morphology in artificially defoliated silver birch seedlings ?
24231764	0	carbon	35,41	CO2	58,61	carbon	CO2	MESH:D002244	717	Chemical	Gene	Synthesis|nmod|START_ENTITY nanospheres|nsubj|Synthesis nanospheres|nmod|capture capture|compound|END_ENTITY	Synthesis of nitrogen-doped hollow carbon nanospheres for CO2 capture .
24281683	0	carbon	7,13	CO2	43,46	carbon	CO2	MESH:D002244	717	Chemical	Gene	ratio|compound|START_ENTITY ratio|nmod|END_ENTITY	Stable carbon isotope ratio in atmospheric CO2 collected by new diffusive devices .
24293210	0	carbon	7,13	CO2	40,43	carbon	CO2	MESH:D002244	717	Chemical	Gene	retention|compound|START_ENTITY compensates|nsubj|retention compensates|nmod|END_ENTITY	Labile carbon retention compensates for CO2 released by priming in forest soils .
24313374	0	carbon	7,13	CO2	113,116	carbon	CO2	MESH:D002244	717	Chemical	Gene	isotopes|compound|START_ENTITY received|nsubj|isotopes received|nmod|bioindicators bioindicators|nmod|emission emission|nmod|END_ENTITY	Stable carbon isotopes of glucose received from pine tree-rings as bioindicators of local industrial emission of CO2 in Niepo omice Forest -LRB- 1950-2000 -RRB- .
24488674	0	carbon	90,96	CO2	32,35	carbon	CO2	MESH:D002244	717	Chemical	Gene	nanotubes|compound|START_ENTITY exploration|nmod|nanotubes capture|dep|exploration capture|compound|END_ENTITY	Electrocatalytically switchable CO2 capture : first principle computational exploration of carbon nanotubes with pyridinic_nitrogen .
24488677	0	carbon	90,96	CO2	32,35	carbon	CO2	MESH:D002244	717	Chemical	Gene	nanotubes|compound|START_ENTITY exploration|nmod|nanotubes capture|dep|exploration capture|compound|END_ENTITY	Electrocatalytically switchable CO2 capture : first principle computational exploration of carbon nanotubes with pyridinic_nitrogen .
24496498	0	carbon	78,84	CO2	115,118	carbon	CO2	MESH:D002244	717	Chemical	Gene	nanotubes|compound|START_ENTITY nanotubes|acl|using using|dobj|END_ENTITY	Catalytic nanoreactors in continuous flow : hydrogenation inside single-walled carbon nanotubes using supercritical CO2 .
24748331	0	carbon	47,53	CO2	76,79	carbon	CO2	MESH:D002244	717	Chemical	Gene	storage|compound|START_ENTITY storage|nmod|effect effect|compound|END_ENTITY	Sensitivity of global and regional terrestrial carbon storage to the direct CO2 effect and climate change based on the CMIP5 model intercomparison .
24802350	0	carbon	13,19	CO2	65,68	carbon	CO2	MESH:D002244	717	Chemical	Gene	redistribution|compound|START_ENTITY redistribution|dep|role role|nmod|emissions emissions|nummod|END_ENTITY	Soil organic carbon redistribution by water erosion -- the role of CO2 emissions for the carbon budget .
24802350	0	carbon	87,93	CO2	65,68	carbon	CO2	MESH:D002244	717	Chemical	Gene	budget|compound|START_ENTITY emissions|nmod|budget emissions|nummod|END_ENTITY	Soil organic carbon redistribution by water erosion -- the role of CO2 emissions for the carbon budget .
24844873	1	carbon	69,75	CO2	143,146	carbon	CO2	MESH:D002244	717	Chemical	Gene	allocation|compound|START_ENTITY intercomparison|nmod|allocation processes|nsubj|intercomparison processes|nmod|sites sites|compound|END_ENTITY	A model-data intercomparison of vegetation carbon allocation and turnover processes at two temperate forest free-air CO2 enrichment sites .
25036641	0	carbon	71,77	CO2	150,153	carbon	CO2	MESH:D002244	717	Chemical	Gene	riverine|dobj|START_ENTITY Response|acl|riverine Response|dep|implications implications|nmod|emission emission|compound|END_ENTITY	Response of bacterial metabolic activity to riverine dissolved organic carbon and exogenous viruses in estuarine and coastal waters : implications for CO2 emission .
25125286	0	carbon	56,62	CO2	39,42	carbon	CO2	MESH:D002244	717	Chemical	Gene	capture|compound|START_ENTITY leakage|nmod|capture leakage|nsubj|Simulation Simulation|nmod|effects effects|nmod|END_ENTITY	Simulation of the potential effects of CO2 leakage from carbon capture and storage activities on the mobilization and speciation of metals .
25127295	0	carbon	35,41	CO2	72,75	carbon	CO2	MESH:D002244	717	Chemical	Gene	performance|nmod|START_ENTITY supported|nsubj|performance supported|nmod|reforming reforming|compound|END_ENTITY	Catalytic performance of activated carbon supported cobalt catalyst for CO2 reforming of CH4 .
25240792	0	carbon	39,45	CO2	101,104	carbon	CO2	MESH:D002244	717	Chemical	Gene	macrophytes|nmod|START_ENTITY concentrations|amod|macrophytes concentrations|nmod|END_ENTITY	Adaptation by macrophytes to inorganic carbon down a river with naturally variable concentrations of CO2 .
25348688	0	carbon	59,65	CO2	118,121	carbon	CO2	MESH:D002244	717	Chemical	Gene	cycling|compound|START_ENTITY impacts|nmod|cycling differ|nmod|impacts differ|nmod|forests forests|acl|exposed exposed|nmod|END_ENTITY	The rhizosphere and hyphosphere differ in their impacts on carbon and nitrogen cycling in forests exposed to elevated CO2 .
25392967	0	carbon	17,23	CO2	59,62	carbon	CO2	MESH:D002244	717	Chemical	Gene	storage|compound|START_ENTITY storage|nmod|END_ENTITY	Increased forest carbon storage with increased atmospheric CO2 despite nitrogen limitation : a game-theoretic allocation model for trees in competition for nitrogen and light .
25548156	0	carbon	44,50	CO2	21,24	carbon	CO2	MESH:D002244	717	Chemical	Gene	cycle|compound|START_ENTITY END_ENTITY|nmod|cycle	Effect of increasing CO2 on the terrestrial carbon cycle .
25902501	0	carbon	9,15	CO2	101,104	carbon	CO2	MESH:D002244	717	Chemical	Gene	storage|compound|START_ENTITY unlikely|nsubj|storage unlikely|xcomp|trigger trigger|dobj|earthquakes earthquakes|acl:relcl|leak leak|nsubj|END_ENTITY	Geologic carbon storage is unlikely to trigger large earthquakes and reactivate faults through which CO2 could leak .
25907601	0	carbon	36,42	CO2	116,119	carbon	CO2	MESH:D002244	717	Chemical	Gene	START_ENTITY|nmod|strategy strategy|nmod|enhancement enhancement|nmod|uptake uptake|compound|END_ENTITY	Creating extra pores in microporous carbon via a template strategy for a remarkable enhancement of ambient-pressure CO2 uptake .
25945400	0	carbon	127,133	CO2	58,61	carbon	CO2	MESH:D002244	717	Chemical	Gene	sequestration|compound|START_ENTITY implications|nmod|sequestration relations|dep|implications relations|nmod|END_ENTITY	Capillary pressure-saturation relations for supercritical CO2 and brine in limestone/dolomite sands : implications for geologic carbon sequestration in carbonate reservoirs .
25973988	0	carbon	55,61	CO2	9,12	carbon	CO2	MESH:D002244	717	Chemical	Gene	metabolism|compound|START_ENTITY improves|nmod|metabolism improves|nsubj|END_ENTITY	Elevated CO2 improves lipid accumulation by increasing carbon metabolism in Chlorella sorokiniana .
26021853	0	carbon	104,110	CO2	39,42	carbon	CO2	MESH:D002244	717	Chemical	Gene	nanotubes|compound|START_ENTITY adsorbed|nmod|nanotubes adsorbed|nsubj|reduction reduction|nmod|CO CO|compound|END_ENTITY	Selective electrochemical reduction of CO2 to CO with a cobalt_chlorin complex adsorbed on multi-walled carbon nanotubes in water .
26021853	0	carbon	104,110	CO2	39,42	carbon	CO2	MESH:D002244	717	Chemical	Gene	nanotubes|compound|START_ENTITY adsorbed|nmod|nanotubes adsorbed|nsubj|reduction reduction|nmod|CO CO|compound|END_ENTITY	Selective electrochemical reduction of CO2 to CO with a cobalt_chlorin complex adsorbed on multi-walled carbon nanotubes in water .
26039985	0	carbon	77,83	CO2	42,45	carbon	CO2	MESH:D002244	717	Chemical	Gene	sinks|compound|START_ENTITY potential|nmod|sinks amplifies|dobj|potential amplifies|nsubj|limitation limitation|nmod|END_ENTITY	Decreased water limitation under elevated CO2 amplifies potential for forest carbon sinks .
26040750	0	carbon	11,17	CO2	94,97	carbon	CO2	MESH:D002244	717	Chemical	Gene	adsorbents|nsubj|START_ENTITY adsorbents|nmod|resin resin|acl|using using|advcl|nanocasting nanocasting|nmod|adsorption adsorption|compound|END_ENTITY	Mesoporous carbon adsorbents from melamine-formaldehyde resin using nanocasting technique for CO2 adsorption .
26144215	0	carbon	61,67	CO2	119,122	carbon	CO2	MESH:D002244	717	Chemical	Gene	hollow|compound|START_ENTITY route|nmod|hollow spheres|nsubj|route spheres|nmod|content content|nmod|adsorption adsorption|compound|END_ENTITY	A one-step carbonization route towards nitrogen-doped porous carbon hollow spheres with ultrahigh nitrogen content for CO2 adsorption .
26148706	0	carbon	60,66	CO2	86,89	carbon	CO2	MESH:D002244	717	Chemical	Gene	isotopes|compound|START_ENTITY isotopes|nmod|END_ENTITY	Insulin sensitivity index -LRB- ISI0 , 120 -RRB- potentially linked to carbon isotopes of breath CO2 for pre-diabetes_and_type_2_diabetes .
26217886	0	carbon	48,54	CO2	70,73	carbon	CO2	MESH:D002244	717	Chemical	Gene	adsorbents|compound|START_ENTITY enriched|dobj|adsorbents enriched|nmod|capture capture|compound|END_ENTITY	Development of nitrogen enriched nanostructured carbon adsorbents for CO2 capture .
26240341	0	carbon	39,45	CO2	102,105	carbon	CO2	MESH:D002244	717	Chemical	Gene	storage|compound|START_ENTITY storage|acl:relcl|remains remains|xcomp|strategy strategy|acl|reduce reduce|dobj|emissions emissions|nummod|END_ENTITY	Reply to Zoback and Gorelick : Geologic carbon storage remains a safe strategy to significantly reduce CO2 emissions .
26313640	0	carbon	40,46	CO2	71,74	carbon	CO2	MESH:D002244	717	Chemical	Gene	dynamics|compound|START_ENTITY model|nmod|dynamics Application|nmod|model Application|nmod|END_ENTITY	Application of a two-pool model to soil carbon dynamics under elevated CO2 .
26319871	0	carbon	102,108	CO2	136,139	carbon	CO2	MESH:D002244	717	Chemical	Gene	systems|compound|START_ENTITY expression|nmod|systems differ|nmod|expression differ|nmod|END_ENTITY	Strains of the harmful cyanobacterium Microcystis differ in gene expression and activity of inorganic carbon uptake systems at elevated CO2 .
26426394	0	carbon	11,17	CO2	112,115	carbon	CO2	MESH:D002244	717	Chemical	Gene	responses|compound|START_ENTITY woodland|nsubj|responses woodland|nmod|enrichment enrichment|nmod|concentration concentration|compound|END_ENTITY	Short-term carbon cycling responses of a mature eucalypt woodland to gradual stepwise enrichment of atmospheric CO2 concentration .
26484690	0	carbon	109,115	CO2	27,30	carbon	CO2	MESH:D002244	717	Chemical	Gene	nanotubes|compound|START_ENTITY supported|nmod|nanotubes supported|nsubj|difference difference|nmod|hydrogenation hydrogenation|nummod|END_ENTITY	A remarkable difference in CO2 hydrogenation to methanol on Pd nanoparticles supported inside and outside of carbon nanotubes .
26520559	0	carbon	24,30	CO2	50,53	carbon	CO2	MESH:D002244	717	Chemical	Gene	array|compound|START_ENTITY array|nmod|adsorption adsorption|compound|END_ENTITY	Erratum : `` Double-walled carbon nanotube array for CO2 and SO2 adsorption '' -LSB- J. Chem .
26543753	0	carbon	4,10	CO2	39,42	carbon	CO2	MESH:D002244	717	Chemical	Gene	transportation|compound|START_ENTITY transportation|dep|strategy strategy|compound|END_ENTITY	Low carbon transportation in Thailand : CO2 mitigation strategy in 2050 .
26671348	0	carbon	14,20	CO2	101,104	carbon	CO2	MESH:D002244	717	Chemical	Gene	capture|nsubj|START_ENTITY capture|advcl|gate-opening gate-opening|nmod|pressures pressures|compound|END_ENTITY	Enhancing the carbon capture capacities of a rigid ultra-microporous MOF through gate-opening at low CO2 pressures assisted by swiveling oxalate pillars .
26745293	0	carbon	20,26	CO2	118,121	carbon	CO2	MESH:D002244	717	Chemical	Gene	drainage|nsubj|START_ENTITY drainage|xcomp|interacting interacting|nmod|END_ENTITY	Dissolved inorganic carbon and stable carbon isotopic evolution of neutral mine drainage interacting with atmospheric CO2 -LRB- g -RRB- .
8193205	0	carbon	22,28	CO2	52,55	carbon	CO2	MESH:D002244	717	Chemical	Gene	composition|compound|START_ENTITY composition|nmod|END_ENTITY	-LSB- Daily changes in the carbon isotope composition of CO2 in expired air of persons with various metabolic_disorders -RSB- .
9906136	0	carbon	151,157	CO2	195,198	carbon	CO2	MESH:D002244	717	Chemical	Gene	1s|compound|START_ENTITY 1s|acl|excitation excitation|nmod|END_ENTITY	Angle-resolved electron-energy-loss study of core-level electron excitation in molecules : Determination of the generalized oscillator strength for the carbon 1s -LRB- 2 sigma g -- > 2 pi u -RRB- excitation in CO2 .
10628872	0	carbon	83,89	Cat8p	0,5	carbon	Cat8p	MESH:D002244	855323(Tax:4932)	Chemical	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Cat8p , the activator of gluconeogenic genes in Saccharomyces_cerevisiae , regulates carbon source-dependent expression of NADP-dependent cytosolic isocitrate dehydrogenase -LRB- Idp2p -RRB- and lactate permease -LRB- Jen1p -RRB- .
17183215	0	carbon	49,55	CcpA	70,74	carbon	CcpA	MESH:D002244	935942(Tax:224308)	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|nmod|END_ENTITY	Transcriptome analysis of temporal regulation of carbon metabolism by CcpA in Bacillus_subtilis reveals additional target genes .
22288715	0	carbon	29,35	Fructokinase	0,12	carbon	Fructokinase	MESH:D002244	3795	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Fructokinase is required for carbon partitioning to cellulose in aspen wood .
7748928	0	carbon	24,30	H-NS	12,16	carbon	H-NS	MESH:D002244	13905950	Chemical	Gene	metabolism|compound|START_ENTITY role|nmod|metabolism role|nmod|END_ENTITY	The role of H-NS in one carbon metabolism .
20192182	0	carbon	81,87	IL-6	70,74	carbon	IL-6	MESH:D002244	3569	Chemical	Gene	using|dobj|START_ENTITY END_ENTITY|acl|using	Ultrasensitive electrochemical immunosensor for oral_cancer biomarker IL-6 using carbon nanotube forest electrodes and multilabel amplification .
16686191	0	carbon	30,36	PBS	23,26	carbon	PBS	MESH:D002244	1131	Chemical	Gene	source|compound|START_ENTITY END_ENTITY|nmod|source	-LSB- Denitrification using PBS as carbon source and biofilm supporter : effect of pH -RSB- .
23463282	0	carbon	45,51	POC_and_DOC	53,64	carbon	POC and DOC	MESH:D002244	5443	Chemical	Gene	distribution|nmod|START_ENTITY distribution|appos|END_ENTITY	Spatial distribution and mobility of organic carbon -LRB- POC_and_DOC -RRB- in a coastal Mediterranean environment -LRB- Saronikos Gulf , Greece -RRB- during 2007-2009 period .
6139726	0	carbon	66,72	Somatostatin	0,12	carbon	Somatostatin	MESH:D002244	24797(Tax:10116)	Chemical	Gene	uptake|nmod|START_ENTITY stimulates|dobj|uptake stimulates|nsubj|END_ENTITY	Somatostatin stimulates clearance and hepatic uptake of colloidal carbon in the rat .
25584433	0	carbon	44,50	TRAIL	21,26	carbon	TRAIL	MESH:D002244	8743	Chemical	Gene	nanotubes|compound|START_ENTITY END_ENTITY|nmod|nanotubes	Nanovectorization of TRAIL with single wall carbon nanotubes enhances tumor cell killing .
18848914	0	carbon	67,73	alpha-fetoprotein	40,57	carbon	alpha-fetoprotein	MESH:D002244	174	Chemical	Gene	based|nmod|START_ENTITY END_ENTITY|acl|based	Sensitive amperometric immunosensor for alpha-fetoprotein based on carbon nanotube/gold nanoparticle doped chitosan film .
21516989	0	carbon	58,64	bisphenol_A	17,28	carbon	bisphenol A	MESH:D002244	667	Chemical	Gene	removal|nmod|START_ENTITY removal|nmod|END_ENTITY	Rapid removal of bisphenol_A on highly ordered mesoporous carbon .
24373252	0	carbon	67,73	citrate_synthase	42,58	carbon	citrate synthase	MESH:D002244	5728523(Tax:3055)	Chemical	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Effect of the expression and knockdown of citrate_synthase gene on carbon flux during triacylglycerol biosynthesis by green algae Chlamydomonas_reinhardtii .
16682066	0	carbon	22,28	p-nitrophenol	47,60	carbon	p-nitrophenol	MESH:D002244	4860	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of activated carbon on the removal of p-nitrophenol in an integrated three-phase electrochemical reactor .
16734451	0	carbon	61,67	sp2	87,90	carbon	sp2	MESH:D002244	6668	Chemical	Gene	film|compound|START_ENTITY film|acl|consisting consisting|nmod|END_ENTITY	Electrochemical performance of angstrom level flat sputtered carbon film consisting of sp2 and sp3 mixed bonds .
17949042	0	carbon	40,46	sp2	36,39	carbon	sp2	MESH:D002244	6668	Chemical	Gene	linkers|compound|START_ENTITY linkers|amod|END_ENTITY	Bis - -LRB- 2,5-diphenylphospholanes -RRB- with sp2 carbon linkers : synthesis and application in asymmetric hydrogenation .
22232218	0	carbon	38,44	sp2	3,6	carbon	sp2	MESH:D002244	6668	Chemical	Gene	film|compound|START_ENTITY film|amod|END_ENTITY	An sp2 and sp3 hybrid nanocrystalline carbon film electrode for anodic stripping voltammetry and its application for electrochemical immunoassay .
22402605	0	carbon	109,115	sp2	80,83	carbon	sp2	MESH:D002244	6668	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Fermi energy level tuning for high performance dye sensitized solar cells using sp2 selective nitrogen-doped carbon nanotube channels .
23187896	0	carbon	29,35	sp2	68,71	carbon	sp2	MESH:D002244	6668	Chemical	Gene	semiconductors|compound|START_ENTITY semiconductors|nmod|configuration configuration|amod|END_ENTITY	Two viable three-dimensional carbon semiconductors with an entirely sp2 configuration .
23565654	0	carbon	73,79	sp2	69,72	carbon	sp2	MESH:D002244	6668	Chemical	Gene	materials|compound|START_ENTITY materials|amod|END_ENTITY	Controlling the effective surface area and pore size distribution of sp2 carbon materials and their impact on the capacitance performance of these materials .
24325138	0	carbon	66,72	sp2	62,65	carbon	sp2	MESH:D002244	6668	Chemical	Gene	surfaces|compound|START_ENTITY surfaces|amod|END_ENTITY	Spatial and temporal control of the diazonium modification of sp2 carbon surfaces .
25222600	0	carbon	10,16	sp2	92,95	carbon	sp2	MESH:D002244	6668	Chemical	Gene	bonds|compound|START_ENTITY Sculpting|dobj|bonds Sculpting|nmod|re-engineering re-engineering|nmod|carbon carbon|amod|END_ENTITY	Sculpting carbon bonds for allotropic transformation through solid-state re-engineering of - sp2 carbon .
12005586	0	carbon	59,65	spin	33,37	carbon	spin	MESH:D002244	10927	Chemical	Gene	nanotubes|compound|START_ENTITY END_ENTITY|nmod|nanotubes	Spin-orbit coupling and electron spin resonance theory for carbon nanotubes .
24121703	0	carbon_alcohols	24,39	CO2	13,16	carbon alcohols	CO2	null	717	Chemical	Gene	Reduction|nmod|START_ENTITY Reduction|nmod|END_ENTITY	Reduction of CO2 to low carbon_alcohols on CuO FCs/Fe2O3 NTs catalyst with photoelectric dual catalytic interfaces .
18052948	0	carbon_dioxide	10,24	calcitonin_gene-related_peptide	28,59	carbon dioxide	calcitonin gene-related peptide	MESH:D002245	796	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|amod|END_ENTITY	Effect of carbon_dioxide on calcitonin_gene-related_peptide secretion from trigeminal neurons .
21905036	0	carbon_dioxide	51,65	growth_hormone	19,33	carbon dioxide	growth hormone	MESH:D002245	2688	Chemical	Gene	Stability|nmod|START_ENTITY Stability|nmod|END_ENTITY	Stability of human growth_hormone in supercritical carbon_dioxide .
8049836	0	carbon_dioxide	73,87	growth_hormone	110,124	carbon dioxide	growth hormone	MESH:D002245	2688	Chemical	Gene	response|nmod|START_ENTITY response|nmod|END_ENTITY	Central sleep_apnea is associated with increased ventilatory response to carbon_dioxide and hypersecretion of growth_hormone in patients with acromegaly .
6770525	0	carbon_dioxide	20,34	malate_dehydrogenase	38,58	carbon dioxide	malate dehydrogenase	MESH:D002245	4199	Chemical	Gene	role|nmod|START_ENTITY role|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Regulatory role of carbon_dioxide in malate_dehydrogenase reaction -RSB- .
15128553	0	carbon_dioxide	36,50	neurotoxin	91,101	carbon dioxide	neurotoxin	MESH:D002245	20490862	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Quantitative interaction effects of carbon_dioxide , sodium_chloride , and sodium_nitrite on neurotoxin gene expression in nonproteolytic Clostridium_botulinum type B .
18310434	0	carbon_dioxide	11,25	neurotoxin	29,39	carbon dioxide	neurotoxin	MESH:D002245	20490862	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effects of carbon_dioxide on neurotoxin gene expression in nonproteolytic Clostridium_botulinum Type E. Carbon_dioxide is an antimicrobial gas commonly used in modified atmosphere packaging .
22531167	0	carbon_dioxide	20,34	tank	115,119	carbon dioxide	tank	MESH:D002245	10010	Chemical	Gene	removal|nmod|START_ENTITY removal|nmod|END_ENTITY	Enhanced removal of carbon_dioxide and alleviation of dissolved oxygen accumulation in photobioreactor with bubble tank .
6100102	0	carbon_disulfide	65,81	angiotensin_I_converting_enzyme	17,48	carbon disulfide	angiotensin I converting enzyme	MESH:D002246	1636	Chemical	Gene	due|xcomp|START_ENTITY END_ENTITY|xcomp|due	Changes in serum angiotensin_I_converting_enzyme activity due to carbon_disulfide exposure .
17953200	0	carbon_disulfide	47,63	c-myc	67,72	carbon disulfide	c-myc	MESH:D002246	24577(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Study of the possible mechanism of effects of carbon_disulfide on c-myc expression in rat testicles -RSB- .
21241594	0	carbon_disulfide	11,27	matrix_metalloproteinase-2_and_metalloproteinase-9	45,95	carbon disulfide	matrix metalloproteinase-2 and metalloproteinase-9	MESH:D002246	17390(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Effect of carbon_disulfide on expression of matrix_metalloproteinase-2_and_metalloproteinase-9 in embryo and uterus of pregnant mice -RSB- .
15251861	0	carbon_monoxide	23,38	Angiotensin_II	0,14	carbon monoxide	Angiotensin II	MESH:D002248	24179(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Angiotensin_II induces carbon_monoxide production in the perfused kidney : relationship to protein kinase C activation .
10883739	0	carbon_monoxide	58,73	Endothelin-1	0,12	carbon monoxide	Endothelin-1	MESH:D002248	100294653(Tax:9940)	Chemical	Gene	release|parataxis|START_ENTITY release|amod|END_ENTITY	Endothelin-1 release from the lamb ductus arteriosus : are carbon_monoxide and nitric_oxide regulatory agents ?
14512878	0	carbon_monoxide	43,58	Heme_oxygenase-1	0,16	carbon monoxide	Heme oxygenase-1	MESH:D002248	15368(Tax:10090)	Chemical	Gene	prevent|advmod|START_ENTITY prevent|nsubj|END_ENTITY	Heme_oxygenase-1 and its reaction product , carbon_monoxide , prevent inflammation-related apoptotic liver_damage in mice .
17885218	0	carbon_monoxide	146,161	Heme_oxygenase-1	0,16	carbon monoxide	Heme oxygenase-1	MESH:D002248	15368(Tax:10090)	Chemical	Gene	rescued|nmod|START_ENTITY endothelium|acl:relcl|rescued damage|nmod|endothelium accelerates|nmod|damage accelerates|nsubj|deficiency deficiency|amod|END_ENTITY	Heme_oxygenase-1 deficiency accelerates formation of arterial thrombosis through oxidative damage to the endothelium , which is rescued by inhaled carbon_monoxide .
21115498	0	carbon_monoxide	17,32	Heme_oxygenase-1	0,16	carbon monoxide	Heme oxygenase-1	MESH:D002248	24451(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY END_ENTITY|parataxis|induces	Heme_oxygenase-1 / carbon_monoxide induces vascular endothelial growth factor expression via p38 kinase-dependent activation of Sp1 .
22325451	0	carbon_monoxide	30,45	Heme_oxygenase-1	0,16	carbon monoxide	Heme oxygenase-1	MESH:D002248	15368(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|end-products end-products|amod|END_ENTITY	Heme_oxygenase-1 end-products carbon_monoxide and biliverdin_ameliorate murine collagen_induced_arthritis .
24651442	0	carbon_monoxide	25,40	Heme_oxygenase-1	0,16	carbon monoxide	Heme oxygenase-1	MESH:D002248	3162	Chemical	Gene	permits|nsubj|START_ENTITY derived|ccomp|permits derived|nsubj|END_ENTITY	Heme_oxygenase-1 derived carbon_monoxide permits maturation of myeloid cells .
25501830	0	carbon_monoxide	81,96	Heme_oxygenase-1	0,16	carbon monoxide	Heme oxygenase-1	MESH:D002248	3162	Chemical	Gene	production|amod|START_ENTITY toxicity|nmod|production protects|nmod|toxicity protects|nsubj|END_ENTITY	Heme_oxygenase-1 protects against Alzheimer 's amyloid-b1-42-induced toxicity via carbon_monoxide production .
20349048	0	carbon_monoxide	34,49	ICAM-1	13,19	carbon monoxide	ICAM-1	MESH:D002248	15894(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Reduction of ICAM-1 expression by carbon_monoxide via soluble guanylate cyclase activation accounts for modulation of neutrophil migration .
25640654	0	carbon_monoxide	33,48	IRG1	0,4	carbon monoxide	IRG1	MESH:D002248	16365(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	IRG1 induced by heme_oxygenase-1 / carbon_monoxide inhibits LPS-mediated sepsis and pro-inflammatory cytokine production .
24586391	0	carbon_monoxide	53,68	Tristetraprolin	0,15	carbon monoxide	Tristetraprolin	MESH:D002248	22695(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY mediates|dobj|effect mediates|nsubj|END_ENTITY	Tristetraprolin mediates anti-inflammatory effect of carbon_monoxide against DSS-induced colitis .
17923586	0	carbon_monoxide	50,65	angiotensin_II	69,83	carbon monoxide	angiotensin II	MESH:D002248	11606(Tax:10090)	Chemical	Gene	antioxidant|nmod|START_ENTITY antioxidant|nmod|END_ENTITY	Synergetic antioxidant and vasodilatory action of carbon_monoxide in angiotensin_II - induced cardiac_hypertrophy .
27020787	0	carbon_monoxide	12,27	cannabinoid_2_receptors	78,101	carbon monoxide	cannabinoid 2 receptors	MESH:D002248	12802(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of carbon_monoxide on the anti-nociceptive effects and expression of cannabinoid_2_receptors during painful_diabetic_neuropathy in mice .
7106107	2	carbon_monoxide	203,218	cytochrome_P-450	167,183	carbon monoxide	cytochrome P-450	MESH:D002248	4051	Chemical	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	A study using laser flash photolysis of the dynamics of the reduction of bacterial cytochrome_P-450 in the presence of carbon_monoxide .
4276636	0	carbon_monoxide	40,55	cytochrome_P450	81,96	carbon monoxide	cytochrome P450	MESH:D002248	4051	Chemical	Gene	the|nmod|START_ENTITY the|nmod|END_ENTITY	Proceedings : Kinetics of the binding of carbon_monoxide and oxygen to microsomal cytochrome_P450 and the influence of substrates .
5738934	0	carbon_monoxide	20,35	delta-aminolevulinic_acid_dehydratase	52,89	carbon monoxide	delta-aminolevulinic acid dehydratase	MESH:D002248	210	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	-LSB- Action in vitro of carbon_monoxide and lead on the delta-aminolevulinic_acid_dehydratase activity of human erythrocytes -RSB- .
2394729	0	carbon_monoxide	22,37	dopamine_beta-hydroxylase	57,82	carbon monoxide	dopamine beta-hydroxylase	MESH:D002248	1621	Chemical	Gene	complex|amod|START_ENTITY complex|nmod|END_ENTITY	Characterization of a carbon_monoxide complex of reduced dopamine_beta-hydroxylase .
10563519	0	carbon_monoxide	8,23	endothelin-1	60,72	carbon monoxide	endothelin-1	MESH:D002248	24323(Tax:10116)	Chemical	Gene	exposure|compound|START_ENTITY induces|nsubj|exposure induces|dobj|expression expression|amod|END_ENTITY	Chronic carbon_monoxide exposure in vivo induces myocardial endothelin-1 expression and hypertrophy in rat .
5734733	0	carbon_monoxide	20,35	glucose-6-phosphate_dehydrogenase	48,81	carbon monoxide	glucose-6-phosphate dehydrogenase	MESH:D002248	2539	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	-LSB- In vitro effect of carbon_monoxide and lead on glucose-6-phosphate_dehydrogenase activity in human erythrocytes -RSB- .
18303579	0	carbon_monoxide	25,40	hTREK-1	14,21	carbon monoxide	hTREK-1	MESH:D002248	3776	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|END_ENTITY	Modulation of hTREK-1 by carbon_monoxide .
16222043	0	carbon_monoxide	35,50	heme_oxygenase-1	18,34	carbon monoxide	heme oxygenase-1	MESH:D002248	3162	Chemical	Gene	START_ENTITY|nsubj|Cytoprotection Cytoprotection|nmod|/ /|amod|END_ENTITY	Cytoprotection of heme_oxygenase-1 / carbon_monoxide in lung_injury .
16628357	0	carbon_monoxide	110,125	heme_oxygenase-1	93,109	carbon monoxide	heme oxygenase-1	MESH:D002248	24451(Tax:10116)	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Simvastatin inhibits hypertension-induced cardiac_hypertrophy in rats through activation of heme_oxygenase-1 / carbon_monoxide pathway -RSB- .
17173083	0	carbon_monoxide	65,80	heme_oxygenase-1	22,38	carbon monoxide	heme oxygenase-1	MESH:D002248	24451(Tax:10116)	Chemical	Gene	induced|nsubj|START_ENTITY induced|advcl|-LSB- -LSB-|dobj|effect effect|nmod|END_ENTITY	-LSB- Protective effect of heme_oxygenase-1 and its reaction product , carbon_monoxide on acute_liver_injury induced by carbon_tetrachloride in rats -RSB- .
17719563	0	carbon_monoxide	149,164	heme_oxygenase-1	178,194	carbon monoxide	heme oxygenase-1	MESH:D002248	513221(Tax:9913)	Chemical	Gene	START_ENTITY|acl|derived derived|advcl|END_ENTITY	YS_51 , 1 - -LRB- beta-naphtylmethyl -RRB- -6,7 - dihydroxy-1 ,2,3,4 , - tetrahydroisoquinoline , protects endothelial cells against hydrogen_peroxide-induced injury via carbon_monoxide derived from heme_oxygenase-1 .
19265160	0	carbon_monoxide	21,36	heme_oxygenase-1	4,20	carbon monoxide	heme oxygenase-1	MESH:D002248	3162	Chemical	Gene	suppresses|amod|START_ENTITY suppresses|dep|END_ENTITY	The heme_oxygenase-1 / carbon_monoxide pathway suppresses TLR4 signaling by regulating the interaction of TLR4 with caveolin-1 .
19477871	0	carbon_monoxide	25,40	heme_oxygenase-1	8,24	carbon monoxide	heme oxygenase-1	MESH:D002248	100008919(Tax:9986)	Chemical	Gene	system|amod|START_ENTITY Role|dep|system Role|nmod|END_ENTITY	Role of heme_oxygenase-1 / carbon_monoxide system in pulmonary_ischemia-reperfusion_injury .
19520142	0	carbon_monoxide	91,106	heme_oxygenase-1	13,29	carbon monoxide	heme oxygenase-1	MESH:D002248	24451(Tax:10116)	Chemical	Gene	poisoning|compound|START_ENTITY rats|nmod|poisoning attenuates|nmod|rats attenuates|nsubj|Induction Induction|nmod|END_ENTITY	Induction of heme_oxygenase-1 with hemin attenuates hippocampal_injury in rats after acute carbon_monoxide poisoning .
19787335	0	carbon_monoxide	43,58	heme_oxygenase-1	26,42	carbon monoxide	heme oxygenase-1	MESH:D002248	3162	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|/ /|amod|END_ENTITY	Beneficial effects of the heme_oxygenase-1 / carbon_monoxide system in patients with severe sepsis/septic _ shock .
20422170	0	carbon_monoxide	75,90	heme_oxygenase-1	19,35	carbon monoxide	heme oxygenase-1	MESH:D002248	24451(Tax:10116)	Chemical	Gene	poisoning|compound|START_ENTITY changes|nmod|poisoning changes|nmod|END_ENTITY	Dynamic changes of heme_oxygenase-1 in the hippocampus of rats after acute carbon_monoxide poisoning .
22391129	0	carbon_monoxide	179,194	heme_oxygenase-1	162,178	carbon monoxide	heme oxygenase-1	MESH:D002248	15368(Tax:10090)	Chemical	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Sensing endoplasmic reticulum stress by protein_kinase_RNA-like_endoplasmic_reticulum_kinase promotes adaptive mitochondrial DNA biogenesis and cell survival via heme_oxygenase-1 / carbon_monoxide activity .
22518295	0	carbon_monoxide	42,57	heme_oxygenase-1	25,41	carbon monoxide	heme oxygenase-1	MESH:D002248	3162	Chemical	Gene	START_ENTITY|nsubj|potential potential|nmod|/ /|amod|END_ENTITY	Therapeutic potential of heme_oxygenase-1 / carbon_monoxide in lung_disease .
24211270	0	carbon_monoxide	140,155	heme_oxygenase-1	17,33	carbon monoxide	heme oxygenase-1	MESH:D002248	3162	Chemical	Gene	heat_shock|nmod|START_ENTITY heat_shock|nsubj|induction induction|nmod|suppresses suppresses|amod|END_ENTITY	The induction of heme_oxygenase-1 suppresses heat_shock protein 90 and the proliferation of human breast_cancer cells through its byproduct carbon_monoxide .
24532288	0	carbon_monoxide	105,120	heme_oxygenase-1	80,96	carbon monoxide	heme oxygenase-1	MESH:D002248	15368(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Suppression Suppression|nmod|trafficking trafficking|nmod|product product|amod|END_ENTITY	Suppression of inflammatory cell trafficking and alveolar simplification by the heme_oxygenase-1 product carbon_monoxide .
24927633	0	carbon_monoxide	90,105	heme_oxygenase-1	16,32	carbon monoxide	heme oxygenase-1	MESH:D002248	3162	Chemical	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Upregulation of heme_oxygenase-1 in colorectal_cancer patients with increased circulation carbon_monoxide levels , potentially affects chemotherapeutic sensitivity .
9828853	0	carbon_monoxide	25,40	heme_oxygenase-1	88,104	carbon monoxide	heme oxygenase-1	MESH:D002248	3162	Chemical	Gene	levels|nmod|START_ENTITY associated|nsubjpass|levels associated|nmod|expression expression|nmod|END_ENTITY	Raised levels of exhaled carbon_monoxide are associated with an increased expression of heme_oxygenase-1 in airway macrophages in asthma : a new marker of oxidative stress .
25503851	0	carbon_monoxide	81,96	heme_oxygenase1	65,80	carbon monoxide	heme oxygenase1	MESH:D002248	101214191	Chemical	Gene	pathways|amod|START_ENTITY pathways|amod|END_ENTITY	Methane-rich water induces cucumber adventitious_rooting through heme_oxygenase1 / carbon_monoxide and Ca -LRB- 2 + -RRB- pathways .
20193612	0	carbon_monoxide	14,29	inducible_nitric_oxide_synthase	51,82	carbon monoxide	inducible nitric oxide synthase	MESH:D002248	100135576(Tax:10141)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Influence of carbon_monoxide on the expression of inducible_nitric_oxide_synthase mRNA in guinea_pigs with allergic_rhinitis . -RSB- .
8620875	0	carbon_monoxide	25,40	leghemoglobin	60,73	carbon monoxide	leghemoglobin	MESH:D002248	100527427	Chemical	Gene	complex|amod|START_ENTITY complex|nmod|END_ENTITY	Hydrogen exchange in the carbon_monoxide complex of soybean leghemoglobin .
15382923	0	carbon_monoxide	22,37	myoglobin	43,52	carbon monoxide	myoglobin	MESH:D002248	4151	Chemical	Gene	process|nmod|START_ENTITY process|nmod|END_ENTITY	The escape process of carbon_monoxide from myoglobin to solution at physiological temperature .
6619112	0	carbon_monoxide	16,31	myoglobin	37,46	carbon monoxide	myoglobin	MESH:D002248	4151	Chemical	Gene	reaction|nmod|START_ENTITY reaction|nmod|END_ENTITY	The reaction of carbon_monoxide with myoglobin in solution , in an amorphous state , and in crystals .
7151787	0	carbon_monoxide	87,102	myoglobin	72,81	carbon monoxide	myoglobin	MESH:D002248	4151	Chemical	Gene	kinetics|nmod|START_ENTITY kinetics|nmod|END_ENTITY	A coupled diffusion and barrier model for the recombination kinetics of myoglobin with carbon_monoxide .
8939867	0	carbon_monoxide	18,33	myoglobin	45,54	carbon monoxide	myoglobin	MESH:D002248	4151	Chemical	Gene	complex|amod|START_ENTITY complex|nmod|END_ENTITY	Photolysis of the carbon_monoxide complex of myoglobin : nanosecond time-resolved crystallography .
23315809	0	carbon_monoxide	118,133	tumor_necrosis_factor-a	29,52	carbon monoxide	tumor necrosis factor-a	MESH:D002248	7124	Chemical	Gene	poisoning|compound|START_ENTITY Association|nmod|poisoning Association|nmod|genes genes|nmod|END_ENTITY	Association of the genes for tumor_necrosis_factor-a and myelin_basic_protein with delayed encephalopathy after acute carbon_monoxide poisoning .
10381180	0	carbon_tetrachloride	29,49	AP-1	6,10	carbon tetrachloride	AP-1	MESH:D002251	24516(Tax:10116)	Chemical	Gene	activation|amod|START_ENTITY activation|compound|END_ENTITY	Liver AP-1 activation due to carbon_tetrachloride is potentiated by 1,2-dibromoethane but is inhibited by alpha-tocopherol or gadolinium_chloride .
3758537	0	carbon_tetrachloride	46,66	CD-1	70,74	carbon tetrachloride	CD-1	MESH:D002251	111334(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|compound|END_ENTITY	Effect of gavage vehicle on hepatotoxicity of carbon_tetrachloride in CD-1 mice : corn oil versus Tween-60 aqueous emulsion .
3225873	0	carbon_tetrachloride	113,133	Glutamate_decarboxylase	0,23	carbon tetrachloride	Glutamate decarboxylase	MESH:D002251	24957(Tax:10116)	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|inhibition inhibition|amod|END_ENTITY	Glutamate_decarboxylase inhibition and vitamin_B6 metabolism in brain of cirrhotic rats chronically treated with carbon_tetrachloride .
15386444	0	carbon_tetrachloride	70,90	TNF-alpha	0,9	carbon tetrachloride	TNF-alpha	MESH:D002251	24835(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|END_ENTITY	TNF-alpha and leptin in experimental liver_fibrosis models induced by carbon_tetrachloride and by common bile duct ligation .
17158861	0	carbon_tetrachloride	76,96	bone_morphogenic_protein-2	24,50	carbon tetrachloride	bone morphogenic protein-2	MESH:D002251	29373(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Transient expression of bone_morphogenic_protein-2 in acute_liver_injury by carbon_tetrachloride .
1717700	0	carbon_tetrachloride	20,40	calmodulin	60,70	carbon tetrachloride	calmodulin	MESH:D002251	808	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activity activity|compound|END_ENTITY	Combined effects of carbon_tetrachloride and chlordecone on calmodulin activity in gerbil brain .
120199	0	carbon_tetrachloride	40,60	cytochrome_P-450	15,31	carbon tetrachloride	cytochrome P-450	MESH:D002251	25251(Tax:10116)	Chemical	Gene	Degradation|nmod|START_ENTITY Degradation|nmod|haem haem|amod|END_ENTITY	Degradation of cytochrome_P-450 haem by carbon_tetrachloride and 2-allyl-2-isopropylacetamide in rat liver in vivo and in vitro .
1594531	0	carbon_tetrachloride	51,71	cytochrome_P-450	31,47	carbon tetrachloride	cytochrome P-450	MESH:D002251	4051	Chemical	Gene	inactivation|nmod|START_ENTITY inactivation|nmod|END_ENTITY	Suicidal inactivation of human cytochrome_P-450 by carbon_tetrachloride and halothane in vitro .
17803	0	carbon_tetrachloride	17,37	cytochrome_P-450	85,101	carbon tetrachloride	cytochrome P-450	MESH:D002251	4051	Chemical	Gene	Bioactivation|nmod|START_ENTITY Bioactivation|dep|role role|nmod|END_ENTITY	Bioactivation of carbon_tetrachloride , chloroform and bromotrichloromethane : role of cytochrome_P-450 .
3233147	0	carbon_tetrachloride	92,112	cytochrome_P-450	46,62	carbon tetrachloride	cytochrome P-450	MESH:D002251	13079(Tax:10090)	Chemical	Gene	influence|nmod|START_ENTITY influence|amod|END_ENTITY	The ratio of two isozyme groups in microsomal cytochrome_P-450 under exogenous influence of carbon_tetrachloride and cyclophosphamide .
435631	0	carbon_tetrachloride	99,119	cytochrome_P-450	38,54	carbon tetrachloride	cytochrome P-450	MESH:D002251	13079(Tax:10090)	Chemical	Gene	-RSB-|amod|START_ENTITY revealed|nmod|-RSB- revealed|nsubj|Heterogeneity Heterogeneity|nmod|distribution distribution|nmod|END_ENTITY	-LSB- Heterogeneity in the distribution of cytochrome_P-450 in the liver lobule revealed on exposure to carbon_tetrachloride -RSB- .
43918	0	carbon_tetrachloride	78,98	cytochrome_P-450	21,37	carbon tetrachloride	cytochrome P-450	MESH:D002251	4051	Chemical	Gene	activation|nmod|START_ENTITY associated|nmod|activation associated|nsubj|loss loss|nmod|END_ENTITY	The apparent loss of cytochrome_P-450 associated with metabolic activation of carbon_tetrachloride .
6700577	0	carbon_tetrachloride	49,69	cytochrome_P-450	85,101	carbon tetrachloride	cytochrome P-450	MESH:D002251	25251(Tax:10116)	Chemical	Gene	metabolism|nmod|START_ENTITY mechanism|nmod|metabolism mechanism|acl|phosgene phosgene|advcl|END_ENTITY	Reductive-oxygenation mechanism of metabolism of carbon_tetrachloride to phosgene by cytochrome_P-450 .
675716	0	carbon_tetrachloride	51,71	cytochrome_P-450	21,37	carbon tetrachloride	cytochrome P-450	MESH:D002251	25251(Tax:10116)	Chemical	Gene	testis|nmod|START_ENTITY END_ENTITY|nmod|testis	Early destruction of cytochrome_P-450 in testis of carbon_tetrachloride poisoned rats .
7071415	0	carbon_tetrachloride	20,40	cytochrome_P-450	75,91	carbon tetrachloride	cytochrome P-450	MESH:D002251	25251(Tax:10116)	Chemical	Gene	Covalent|nmod|START_ENTITY metabolites|nsubj|Covalent metabolites|nmod|moiety moiety|nmod|END_ENTITY	Covalent binding of carbon_tetrachloride metabolites to the heme moiety of cytochrome_P-450 and its degradation products .
7082331	0	carbon_tetrachloride	74,94	cytochrome_P-450	39,55	carbon tetrachloride	cytochrome P-450	MESH:D002251	25251(Tax:10116)	Chemical	Gene	Specificity|nmod|START_ENTITY Specificity|nmod|END_ENTITY	Specificity of a phenobarbital-induced cytochrome_P-450 for metabolism of carbon_tetrachloride to the trichloromethyl radical .
7083393	0	carbon_tetrachloride	24,44	cytochrome_P-450	59,75	carbon tetrachloride	cytochrome P-450	MESH:D002251	25251(Tax:10116)	Chemical	Gene	activation|nmod|START_ENTITY activation|dep|induction induction|nmod|binding binding|amod|END_ENTITY	Metabolic activation of carbon_tetrachloride : induction of cytochrome_P-450 with phenobarbital or 3-methylcholanthrene and its effect on covalent binding .
2194325	0	carbon_tetrachloride	15,35	cytochrome_P450	70,85	carbon tetrachloride	cytochrome P450	MESH:D002251	4051	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|induction induction|amod|END_ENTITY	Interaction of carbon_tetrachloride with beta-naphthoflavone-mediated cytochrome_P450 induction in winter flounder -LRB- Pseudopleuronectes americanus -RRB- .
9893740	0	carbon_tetrachloride	101,121	cytochrome_P450	50,65	carbon tetrachloride	cytochrome P450	MESH:D002251	100379244(Tax:10141)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Preventive effect of isoflurane on destruction of cytochrome_P450 during reductive dehalogenation of carbon_tetrachloride in guinea-pig liver microsomes .
429868	0	carbon_tetrachloride	10,30	erythropoietin	45,59	carbon tetrachloride	erythropoietin	MESH:D002251	24335(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|production production|compound|END_ENTITY	Effect of carbon_tetrachloride on extrarenal erythropoietin production in rats .
10074269	0	carbon_tetrachloride	48,68	hepatocyte_growth_factor	15,39	carbon tetrachloride	hepatocyte growth factor	MESH:D002251	24446(Tax:10116)	Chemical	Gene	injury|amod|START_ENTITY END_ENTITY|nmod|injury	-LSB- Protection of hepatocyte_growth_factor against carbon_tetrachloride injury in primary rat hepatocyte culture -RSB- .
11971173	0	carbon_tetrachloride	74,94	hepatocyte_growth_factor	22,46	carbon tetrachloride	hepatocyte growth factor	MESH:D002251	24446(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY poisoning|nmod|expression END_ENTITY|nmod|poisoning	-LSB- Protective effect of hepatocyte_growth_factor on hepatocyte poisoning by carbon_tetrachloride and related gene expression in rats -RSB- .
12445174	0	carbon_tetrachloride	113,133	hepatocyte_growth_factor	25,49	carbon tetrachloride	hepatocyte growth factor	MESH:D002251	24446(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Early gene expression of hepatocyte_growth_factor in mononuclear phagocytes of rat liver after administration of carbon_tetrachloride .
7663443	0	carbon_tetrachloride	71,91	p53	141,144	carbon tetrachloride	p53	MESH:D002251	7157	Chemical	Gene	START_ENTITY|dep|not not|nmod|END_ENTITY	Expression of the protooncogene mdm2 markedly increases in response to carbon_tetrachloride but not after partial hepatectomy in contrast to p53 .
20196117	0	carbon_tetrachloride	77,97	signal_transducer_and_activator_of_transcription_3	123,173	carbon tetrachloride	signal transducer and activator of transcription 3	MESH:D002251	20848(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Dissociation between liver_inflammation and hepatocellular damage induced by carbon_tetrachloride in myeloid cell-specific signal_transducer_and_activator_of_transcription_3 gene knockout mice .
11740910	0	carbon_tetrachloride	97,117	tumor_necrosis_factor-alpha	12,39	carbon tetrachloride	tumor necrosis factor-alpha	MESH:D002251	21926(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|role role|nmod|END_ENTITY	The role of tumor_necrosis_factor-alpha in liver toxicity , inflammation , and fibrosis induced by carbon_tetrachloride .
9776568	0	carbon_tetrachloride	112,132	tumor_necrosis_factor_alpha	34,61	carbon tetrachloride	tumor necrosis factor alpha	MESH:D002251	24835(Tax:10116)	Chemical	Gene	administration|nmod|START_ENTITY administration|compound|END_ENTITY	Serum and liver concentrations of tumor_necrosis_factor_alpha and interleukin-1beta following administration of carbon_tetrachloride to male rats .
17190290	0	carbonate	140,149	nuclear_factor_kappaB	15,36	carbonate	nuclear factor kappaB	CHEBI:41609	4790	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	-LSB- Activation of nuclear_factor_kappaB -LRB- NF-kappaB -RRB- , induction of proinflammatory cytokines in vitro and evaluation of biocompatibility of the carbonate ceramic in vivo -RSB- .
2158987	0	carbonate	52,61	transferrin	98,109	carbonate	transferrin	CHEBI:41609	7018	Chemical	Gene	binding|amod|START_ENTITY END_ENTITY|amod|binding	Electron spin echo envelope modulation evidence for carbonate binding to iron -LRB- III -RRB- and copper -LRB- II -RRB- transferrin and lactoferrin .
23646745	0	carbons	89,96	CO2	42,45	carbons	CO2	null	717	Chemical	Gene	capture|nmod|START_ENTITY capture|compound|END_ENTITY	Effect of nano-silica spheres template on CO2 capture of exchange resin-based nanoporous carbons .
25347795	0	carbons	91,98	CO2	57,60	carbons	CO2	null	717	Chemical	Gene	capacity|nmod|START_ENTITY capacity|compound|END_ENTITY	Influence of porous texture and surface chemistry on the CO2 adsorption capacity of porous carbons : acidic and basic site interactions .
19853671	0	carbonyl	111,119	3alpha-hydroxysteroid_dehydrogenase	75,110	carbonyl	3alpha-hydroxysteroid dehydrogenase	CHEBI:23019	8644	Chemical	Gene	reductase|amod|START_ENTITY reductase|amod|END_ENTITY	Contributions of active site residues to cofactor binding and catalysis of 3alpha-hydroxysteroid_dehydrogenase / carbonyl reductase .
7655426	0	carbonyl	96,104	C-6	128,131	carbonyl	C-6	CHEBI:23019	729	Chemical	Gene	function|amod|START_ENTITY function|nmod|END_ENTITY	Biochemical studies of estr-4-ene-3 ,6,17 - trione and 5 alpha-androstan-17-ones with or without a carbonyl function at C-3 and/or C-6 as aromatase inhibitors .
1612603	0	carbonyl	23,31	CBR	43,46	carbonyl	CBR	CHEBI:23019	873	Chemical	Gene	reductase|amod|START_ENTITY gene|amod|reductase gene|appos|END_ENTITY	Linkage mapping of the carbonyl reductase -LRB- CBR -RRB- gene on human chromosome 21 using a DNA polymorphism in the 3 ' untranslated region .
2874797	0	carbonyl	27,35	lysyl_oxidase	60,73	carbonyl	lysyl oxidase	CHEBI:23019	280841(Tax:9913)	Chemical	Gene	moiety|amod|START_ENTITY moiety|nmod|END_ENTITY	Reactivity of a functional carbonyl moiety in bovine aortic lysyl_oxidase .
9829590	0	carbonyl-carbon-11-WAY-100635	25,54	5-hydroxytryptamine-1A	74,96	carbonyl-carbon-11-WAY-100635	5-hydroxytryptamine-1A	null	3350	Chemical	Gene	START_ENTITY|nmod|receptors receptors|amod|END_ENTITY	Quantitative analyses of carbonyl-carbon-11-WAY-100635 binding to central 5-hydroxytryptamine-1A receptors in man .
25281269	0	carbonyl_guanidine	66,84	5-HT2B	105,111	carbonyl guanidine	5-HT2B	null	3357	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	Synthesis and pharmacological evaluation of optically pure , novel carbonyl_guanidine derivatives as dual 5-HT2B and 5-HT7 receptor antagonists .
2502778	0	carbonyls	76,85	lipoxygenase	43,55	carbonyls	lipoxygenase	null	547836(Tax:3847)	Chemical	Gene	activity|dep|START_ENTITY activity|nmod|END_ENTITY	The peroxidase/oxidase activity of soybean lipoxygenase -- I. Triplet excited carbonyls from the reaction with isobutanal and the effect of glutathione .
19598262	0	carboplatin	115,126	Annexin_A4	23,33	carboplatin	Annexin A4	MESH:D016190	307	Chemical	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Enhanced expression of Annexin_A4 in clear cell carcinoma_of_the_ovary and its association with chemoresistance to carboplatin .
18977553	0	carboplatin	99,110	ERCC1	14,19	carboplatin	ERCC1	MESH:D016190	2067	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|Expression Expression|nmod|END_ENTITY	Expression of ERCC1 and class_III_beta-tubulin in non-small_cell_lung_cancer patients treated with carboplatin and paclitaxel .
17208232	0	carboplatin	32,43	ERK	14,17	carboplatin	ERK	MESH:D016190	5594	Chemical	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	p53 regulates ERK activation in carboplatin induced apoptosis_in_cervical_carcinoma : a novel target of p53 in apoptosis .
8106154	0	carboplatin	10,21	GM-CSF	40,46	carboplatin	GM-CSF	MESH:D016190	1437	Chemical	Gene	chemotherapy|compound|START_ENTITY chemotherapy|nmod|END_ENTITY	High-dose carboplatin chemotherapy with GM-CSF and peripheral blood progenitor cell support : a model for delivering repeated cycles of dose-intensive therapy .
17063488	0	carboplatin	34,45	Gadd45alpha	0,11	carboplatin	Gadd45alpha	MESH:D016190	1647	Chemical	Gene	modulate|dobj|START_ENTITY modulate|nsubj|END_ENTITY	Gadd45alpha does not modulate the carboplatin or 5-fluorouracil-induced apoptosis in human_papillomavirus-positive cells .
23564368	0	carboplatin	62,73	HER2	103,107	carboplatin	HER2	MESH:D016190	2064	Chemical	Gene	START_ENTITY|nmod|breast_cancer breast_cancer|compound|END_ENTITY	Thrombotic_microangiopathy during docetaxel , trastuzumab , and carboplatin chemotherapy for early-stage HER2 + breast_cancer : a case report .
16884360	0	carboplatin	37,48	Interferon-gamma	0,16	carboplatin	Interferon-gamma	MESH:D016190	3458	Chemical	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	Interferon-gamma in combination with carboplatin and paclitaxel as a safe and effective first-line treatment option for advanced ovarian_cancer : results of a phase I/II study .
26186909	0	carboplatin	21,32	RUNX3	0,5	carboplatin	RUNX3	MESH:D016190	864	Chemical	Gene	contributes|xcomp|START_ENTITY contributes|nsubj|END_ENTITY	RUNX3 contributes to carboplatin resistance in epithelial_ovarian_cancer cells .
26186909	0	carboplatin	21,32	RUNX3	0,5	carboplatin	RUNX3	MESH:D016190	864	Chemical	Gene	contributes|xcomp|START_ENTITY contributes|nsubj|END_ENTITY	RUNX3 contributes to carboplatin resistance in epithelial_ovarian_cancer cells .
16475204	0	carboplatin	38,49	S-1	20,23	carboplatin	S-1	MESH:D016190	5707	Chemical	Gene	combined|nmod|START_ENTITY combined|nsubj|study study|nmod|END_ENTITY	Phase I/II study of S-1 combined with carboplatin in recurrent and/or metastatic head_and_neck_cancer as outpatient chemotherapy .
23277482	0	carboplatin	80,91	S-1	56,59	carboplatin	S-1	MESH:D016190	5707	Chemical	Gene	analysis|nmod|START_ENTITY analysis|nmod|END_ENTITY	Efficacy and safety analysis according to histology for S-1 in combination with carboplatin as first-line chemotherapy in patients with advanced non-small-cell_lung_cancer : updated results of the West Japan Oncology Group LETS study .
24029657	5	carboplatin	748,759	VCAM-1	775,781	carboplatin	VCAM-1	MESH:D016190	22329(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	The effects of carboplatin on mesothelial VCAM-1 expression were determined in cultured cells by Western blot .
12926551	0	carboplatin	115,126	caspase_3	13,22	carboplatin	caspase 3	MESH:D016190	836	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of caspase_3 and modulation of some apoptotic genes in human acute_promyelocytic_leukemia HL-60 cells by carboplatin with amifostine .
8630941	0	carboplatin	25,36	granulocyte-colony_stimulating_factor	68,105	carboplatin	granulocyte-colony stimulating factor	MESH:D016190	1440	Chemical	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	Dose escalation study of carboplatin with fixed-dose etoposide plus granulocyte-colony_stimulating_factor in patients with small_cell_lung_carcinoma .
8826913	0	carboplatin	20,31	granulocyte-colony_stimulating_factor	56,93	carboplatin	granulocyte-colony stimulating factor	MESH:D016190	1440	Chemical	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	Phase I/II study of carboplatin and oral etoposide with granulocyte-colony_stimulating_factor in advanced nonsmall_cell_lung_cancer .
11142689	0	carboplatin	17,28	granulocyte_colony_stimulating_factor	78,115	carboplatin	granulocyte colony stimulating factor	MESH:D016190	1440	Chemical	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	Phase I study of carboplatin , docetaxel and irinotecan with recombinant human granulocyte_colony_stimulating_factor support in patients with advanced non-small_cell_lung_cancer .
7847805	0	carboplatin	40,51	interleukin-1_alpha	72,91	carboplatin	interleukin-1 alpha	MESH:D016190	3552	Chemical	Gene	activities|nmod|START_ENTITY Potentiation|nmod|activities Potentiation|nmod|END_ENTITY	Potentiation of antitumor activities of carboplatin and camptothecin by interleukin-1_alpha against human ovarian_carcinoma in vivo .
8437596	0	carboplatin	87,98	interleukin-1_alpha	30,49	carboplatin	interleukin-1 alpha	MESH:D016190	3552	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of treatment with interleukin-1_alpha on platelet recovery after high-dose carboplatin .
8912565	0	carboplatin	54,65	interleukin-1_alpha	130,149	carboplatin	interleukin-1 alpha	MESH:D016190	3552	Chemical	Gene	associated|nmod|START_ENTITY associated|nmod|END_ENTITY	A characteristic eruption associated with ifosfamide , carboplatin , and etoposide chemotherapy after pretreatment with recombinant interleukin-1_alpha .
17467426	0	carboplatin-taxane	29,47	cN2	90,93	carboplatin-taxane	cN2	null	55748	Chemical	Gene	chemoradiotherapy|dep|START_ENTITY chemoradiotherapy|nmod|END_ENTITY	Induction chemoradiotherapy -LRB- carboplatin-taxane and concurrent 50-Gy radiation -RRB- for bulky cN2 , N3 non-small_cell_lung_cancer .
24689484	0	carborane	21,30	P2X7_receptor	40,53	carborane	P2X7 receptor	CHEBI:38282	5027	Chemical	Gene	START_ENTITY|dep|antagonist antagonist|amod|END_ENTITY	The first CNS-active carborane : A novel P2X7_receptor antagonist with antidepressant activity .
14980620	0	carbothioamides	113,128	inducible_nitric_oxide_synthase	165,196	carbothioamides	inducible nitric oxide synthase	null	4843	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Synthesis , structural investigations and biological evaluation of novel hexahydropyridazine-1-carboximidamides , - carbothioamides and - carbothioimidic_acid_esters as inducible_nitric_oxide_synthase inhibitors .
20659802	0	carboxamides	40,52	adenosine_A2A_receptor	111,133	carboxamides	adenosine A2A receptor	CHEBI:37622	135	Chemical	Gene	START_ENTITY|nmod|antagonists antagonists|amod|END_ENTITY	Hit-to-lead optimization of a series of carboxamides of ethyl_2-amino-4-phenylthiazole-5-carboxylates as novel adenosine_A2A_receptor antagonists .
6343601	0	carboxamides	14,26	alcohol_dehydrogenase	51,72	carboxamides	alcohol dehydrogenase	CHEBI:37622	78959(Tax:10116)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition by carboxamides and sulfoxides of liver alcohol_dehydrogenase and ethanol metabolism .
10942735	0	carboxy	62,69	KCC2	14,18	carboxy	KCC2	CHEBI:46883	57468	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Dependence of KCC2 K-Cl cotransporter activity on a conserved carboxy terminus tyrosine residue .
11152504	0	carboxy	23,30	M_protein	13,22	carboxy	M protein	CHEBI:46883	9172	Chemical	Gene	terminus|compound|START_ENTITY terminus|compound|END_ENTITY	The membrane M_protein carboxy terminus binds to transmissible gastroenteritis coronavirus core and contributes to core stability .
1472063	0	carboxy	4,11	insulin	85,92	carboxy	insulin	CHEBI:46883	3630	Chemical	Gene	portion|amod|START_ENTITY important|nsubj|portion important|nmod|END_ENTITY	The carboxy terminal 110 amino_acid portion of the insulin_receptor is important for insulin signalling to pyruvate_dehydrogenase .
4041827	0	carboxy	32,39	neurotensin	73,84	carboxy	neurotensin	CHEBI:46883	4922	Chemical	Gene	studies|nmod|START_ENTITY studies|nmod|END_ENTITY	Structure-activity studies with carboxy - and amino-terminal fragments of neurotensin on hypothalamic neurons in vitro .
6298420	0	carboxyalkyl	4,16	enkephalinase	37,50	carboxyalkyl	enkephalinase	null	17380(Tax:10090)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	New carboxyalkyl inhibitors of brain enkephalinase : synthesis , biological activity , and analgesic properties .
6721853	0	carboxybiotin	4,17	pyruvate_carboxylase	29,49	carboxybiotin	pyruvate carboxylase	MESH:C024582	101107484	Chemical	Gene	complex|compound|START_ENTITY complex|nmod|END_ENTITY	The carboxybiotin complex of pyruvate_carboxylase .
18205790	0	carboxybutyrylated_glucosamine	118,148	inducible_nitric_oxide_synthase	14,45	carboxybutyrylated glucosamine	inducible nitric oxide synthase	null	18126(Tax:10090)	Chemical	Gene	cells|nmod|START_ENTITY cells|amod|END_ENTITY	Inhibition of inducible_nitric_oxide_synthase and cyclooxygenase-2 in lipopolysaccharide-stimulated RAW264 .7 cells by carboxybutyrylated_glucosamine takes place via down-regulation of mitogen-activated protein kinase-mediated nuclear factor-kappaB signaling .
4022004	0	carboxykinase	58,71	prolactin	10,19	carboxykinase	prolactin	null	24683(Tax:10116)	Chemical	Gene	activity|compound|START_ENTITY Effect|nmod|activity Effect|nmod|END_ENTITY	Effect of prolactin and glucocorticoids on P-enolpyruvate carboxykinase activity in liver and mammary gland from diabetic and lactating rats .
17302434	0	carboxyl	26,34	10-formyltetrahydrofolate_dehydrogenase	58,97	carboxyl	10-formyltetrahydrofolate dehydrogenase	null	64392(Tax:10116)	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Crystal structures of the carboxyl terminal domain of rat 10-formyltetrahydrofolate_dehydrogenase : implications for the catalytic mechanism of aldehyde dehydrogenases .
23110300	0	carboxyl	59,67	Bax	47,50	carboxyl	Bax	null	581	Chemical	Gene	terminus|compound|START_ENTITY terminus|compound|END_ENTITY	Molecular basis for membrane pore formation by Bax protein carboxyl terminus .
21856303	0	carboxyl	54,62	Bcl-XL	82,88	carboxyl	Bcl-XL	null	598	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Protein oligomerization mediated by the transmembrane carboxyl terminal domain of Bcl-XL .
19636853	0	carboxyl	61,69	Connexin40	89,99	carboxyl	Connexin40	null	2702	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	-LRB- 1 -RRB- H , -LRB- 13 -RRB- C , and -LRB- 15 -RRB- N backbone resonance assignments of the carboxyl terminal domain of Connexin40 .
12023952	0	carboxyl	49,57	FLK-1	114,119	carboxyl	FLK-1	null	16542(Tax:10090)	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	The presence of a single tyrosine residue at the carboxyl domain of vascular_endothelial_growth_factor_receptor-2 / FLK-1 regulates its autophosphorylation and activation of signaling molecules .
20097177	0	carboxyl	110,118	GRP78	138,143	carboxyl	GRP78	null	3309	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Inhibition of NF-kappaB1 and NF-kappaB2 activation in prostate_cancer cells treated with antibody against the carboxyl terminal domain of GRP78 : effect of p53 upregulation .
18401557	0	carboxyl	87,95	Muc3	122,126	carboxyl	Muc3	null	687030(Tax:10116)	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Contribution of the conservative cleavage motif to posttranslational processing of the carboxyl terminal domain of rodent Muc3 .
17367757	0	carboxyl	4,12	NOK	46,49	carboxyl	NOK	null	243659(Tax:10090)	Chemical	Gene	residue|amod|START_ENTITY residue|nmod|END_ENTITY	The carboxyl terminal tyrosine 417 residue of NOK has an autoinhibitory effect on NOK-mediated signaling transductions .
10995736	0	carboxyl	23,31	TGIF	83,87	carboxyl	TGIF	null	7050	Chemical	Gene	protein|amod|START_ENTITY protein|nmod|END_ENTITY	The interaction of the carboxyl terminus-binding protein with the Smad corepressor TGIF is disrupted by a holoprosencephaly mutation in TGIF .
14561230	0	carboxyl	26,34	aquaporin-1	54,65	carboxyl	aquaporin-1	null	358	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Single amino_acids in the carboxyl terminal domain of aquaporin-1 contribute to cGMP-dependent ion channel activation .
14681036	0	carboxyl	2,10	connexin43	30,40	carboxyl	connexin43	null	2697	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	A carboxyl terminal domain of connexin43 is critical for gap junction plaque formation but not for homo - or hetero-oligomerization .
11944087	0	carboxyl	23,31	connexin_50	57,68	carboxyl	connexin 50	null	2703	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Functional role of the carboxyl terminal domain of human connexin_50 in gap junctional channels .
1370824	0	carboxyl	113,121	cytochrome_b5	134,147	carboxyl	cytochrome b5	null	281110(Tax:9913)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Characterization of lysyl residues of NADH-cytochrome_b5 reductase implicated in charge-pairing with active-site carboxyl residues of cytochrome_b5 by site-directed mutagenesis of an expression vector for the flavoprotein .
8609912	0	carboxyl	23,31	dystrophin	51,61	carboxyl	dystrophin	null	1756	Chemical	Gene	region|amod|START_ENTITY region|nmod|END_ENTITY	Phosphorylation of the carboxyl terminal region of dystrophin by mitogen-activated protein -LRB- MAP -RRB- kinase .
8175889	0	carboxyl	91,99	osteostatin	118,129	carboxyl	osteostatin	null	5744	Chemical	Gene	peptide|amod|START_ENTITY peptide|appos|END_ENTITY	Tartrate resistant acid phosphatase activity in rat cultured osteoclasts is inhibited by a carboxyl terminal peptide -LRB- osteostatin -RRB- from parathyroid hormone-related protein .
8240325	0	carboxyl	89,97	rhoGDI	113,119	carboxyl	rhoGDI	null	396	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	Carboxyl methylation of the low molecular weight GTP-binding protein G25K : regulation of carboxyl methylation by rhoGDI .
8025047	0	carboxyl	112,120	rhodopsin	142,151	carboxyl	rhodopsin	null	6010	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Ocular findings in a family with autosomal_dominant_retinitis_pigmentosa and a frameshift mutation altering the carboxyl terminal sequence of rhodopsin .
6549132	0	carboxyl	46,54	thyroglobulin	81,94	carboxyl	thyroglobulin	null	280706(Tax:9913)	Chemical	Gene	region|amod|START_ENTITY region|nmod|END_ENTITY	Identification of hormonogenic domains in the carboxyl terminal region of bovine thyroglobulin .
20683528	0	carboxyl_CdSe	76,89	C-reactive_protein	52,70	carboxyl CdSe	C-reactive protein	null	1401	Chemical	Gene	determination|nmod|START_ENTITY determination|nmod|END_ENTITY	Electrogenerated chemiluminescence determination of C-reactive_protein with carboxyl_CdSe / ZnS core/shell quantum dots .
15326176	0	carboxylate	62,73	P-glycoprotein	14,28	carboxylate	P-glycoprotein	CHEBI:35757	67078(Tax:10090)	Chemical	Gene	mutations|nmod|START_ENTITY END_ENTITY|nmod|mutations	Properties of P-glycoprotein with mutations in the `` catalytic carboxylate '' glutamate residues .
3761315	0	carboxylate	23,34	angiotensin_II	38,52	carboxylate	angiotensin II	CHEBI:35757	24179(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Role of the C-terminal carboxylate in angiotensin_II activity : alcohol , ketone , and ester analogues of angiotensin_II .
17449253	0	carboxylic_acid	44,59	NS3	94,97	carboxylic acid	NS3	CHEBI:33575	3845	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Evaluation of a diverse set of potential P1 carboxylic_acid bioisosteres in hepatitis_C virus NS3 protease inhibitors .
1804048	0	carboxylic_acid	27,42	interferon_gamma	57,73	carboxylic acid	interferon gamma	CHEBI:33575	3458	Chemical	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	Effects of some lipophilic carboxylic_acid on release of interferon_gamma from the human peripheral blood leukocytes .
19422229	0	carboxylic_acid	50,65	matrix_metalloproteinase-13	86,113	carboxylic acid	matrix metalloproteinase-13	CHEBI:33575	171052(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|inhibitors inhibitors|nmod|END_ENTITY	Discovery of potent , selective , and orally active carboxylic_acid based inhibitors of matrix_metalloproteinase-13 .
22424978	0	carboxylic_acid	43,58	protein_tyrosine_phosphatase_1B	74,105	carboxylic acid	protein tyrosine phosphatase 1B	CHEBI:33575	19246(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Discovery of novel and potent heterocyclic carboxylic_acid derivatives as protein_tyrosine_phosphatase_1B inhibitors .
12496283	0	carboxylic_acids	105,121	GPR41	39,44	carboxylic acids	GPR41	MESH:D002264	2865	Chemical	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic_acids .
25826901	0	carboxymethylated_chitosan	11,37	brain_derived_neurotrophic_factor	69,102	carboxymethylated chitosan	brain derived neurotrophic factor	null	24225(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of carboxymethylated_chitosan on apoptosis and expression of brain_derived_neurotrophic_factor and glial_cell_line_derived_neurotrophic_factor in oxidative stress induced Schwann_cells in vitro -RSB- .
21320776	0	carboxyquinolines	43,60	NK3_receptor	64,76	carboxyquinolines	NK3 receptor	null	6870	Chemical	Gene	START_ENTITY|nmod|antagonists antagonists|amod|END_ENTITY	Synthesis and SAR of sulfoxide substituted carboxyquinolines as NK3_receptor antagonists .
20566415	0	cardamonin	21,31	mTOR	47,51	cardamonin	mTOR	MESH:C436747	21977(Tax:10090)	Chemical	Gene	Antiproliferation|nmod|START_ENTITY involved|nsubjpass|Antiproliferation involved|nmod|END_ENTITY	Antiproliferation of cardamonin is involved in mTOR on aortic smooth muscle cells in high fructose-induced insulin resistance rats .
21137347	0	cardamonin	22,32	mTOR	68,72	cardamonin	mTOR	MESH:C436747	21977(Tax:10090)	Chemical	Gene	Antiproliferation|nmod|START_ENTITY associated|nsubj|Antiproliferation associated|nmod|expression expression|nmod|END_ENTITY	-LSB- Antiproliferation of cardamonin associated with mRNA expression of mTOR , Raptor and Rictor -RSB- .
24508654	0	cardamonin	19,29	mTOR	0,4	cardamonin	mTOR	MESH:C436747	21977(Tax:10090)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	mTOR inhibition of cardamonin on antiproliferation of A549 cells is involved in a FKBP12 independent fashion .
21645498	0	cardiolipin	31,42	Atp7b	65,70	cardiolipin	Atp7b	MESH:D002308	11979(Tax:10090)	Chemical	Gene	Fragmentation|nmod|START_ENTITY Fragmentation|nmod|END_ENTITY	Fragmentation of mitochondrial cardiolipin by copper ions in the Atp7b - / - mouse model of Wilson 's _ disease .
16565064	0	cardiolipin	89,100	Cytochrome_C	0,12	cardiolipin	Cytochrome C	MESH:D002308	54205	Chemical	Gene	protonation|compound|START_ENTITY effect|nmod|protonation interaction|dep|effect interaction|amod|END_ENTITY	Cytochrome_C interaction with cardiolipin/phosphatidylcholine model membranes : effect of cardiolipin protonation .
1327134	0	cardiolipin	31,42	Cytochrome_c	0,12	cardiolipin	Cytochrome c	MESH:D002308	54205	Chemical	Gene	interactions|nmod|START_ENTITY interactions|amod|END_ENTITY	Cytochrome_c interactions with cardiolipin in bilayers : a multinuclear magic-angle spinning NMR study .
16408039	0	cardiolipin	23,34	Cytochrome_c	0,12	cardiolipin	Cytochrome c	MESH:D002308	54205	Chemical	Gene	oxygenase|compound|START_ENTITY acts|nmod|oxygenase acts|nsubj|END_ENTITY	Cytochrome_c acts as a cardiolipin oxygenase required for release of proapoptotic factors .
2843287	0	cardiolipin	35,46	S-100b	15,21	cardiolipin	S-100b	MESH:D002308	6285	Chemical	Gene	protein|nmod|START_ENTITY protein|compound|END_ENTITY	Interaction of S-100b protein with cardiolipin vesicles as monitored by electron spin resonance , pyrene fluorescence and circular dichroism .
21559443	0	cardiolipin	38,49	SPG20	0,5	cardiolipin	SPG20	MESH:D002308	23111	Chemical	Gene	associates|nmod|START_ENTITY associates|nummod|END_ENTITY	SPG20 protein spartin associates with cardiolipin via its plant-related senescence domain and regulates mitochondrial Ca2 + homeostasis .
21746876	0	cardiolipin	30,41	Stomatin-like_protein_2	0,23	cardiolipin	Stomatin-like protein 2	MESH:D002308	30968	Chemical	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Stomatin-like_protein_2 binds cardiolipin and regulates mitochondrial biogenesis and function .
1898084	0	cardiolipin	19,30	carbamoyl_phosphate_synthetase_I	46,78	cardiolipin	carbamoyl phosphate synthetase I	MESH:D002308	497840(Tax:10116)	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	The interaction of cardiolipin with rat liver carbamoyl_phosphate_synthetase_I .
17009953	0	cardiolipin	63,74	cytochrome_C	27,39	cardiolipin	cytochrome C	MESH:D002308	104968582	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Mechanism of activation of cytochrome_C peroxidase activity by cardiolipin .
22803508	0	cardiolipin	28,39	cytochrome_C	58,70	cardiolipin	cytochrome C	MESH:D002308	54205	Chemical	Gene	complex|compound|START_ENTITY complex|nmod|END_ENTITY	Nitric_oxide binding to the cardiolipin complex of ferric cytochrome_C .
25247479	0	cardiolipin	22,33	cytochrome_C	58,70	cardiolipin	cytochrome C	MESH:D002308	54205	Chemical	Gene	oxidation|nmod|START_ENTITY affects|nsubj|oxidation affects|dobj|affinity affinity|nmod|END_ENTITY	Not only oxidation of cardiolipin affects the affinity of cytochrome_C for lipid bilayers .
11749969	0	cardiolipin	162,173	cytochrome_c	89,101	cardiolipin	cytochrome c	MESH:D002308	54205	Chemical	Gene	peroxidation|compound|START_ENTITY particles|nmod|peroxidation induce|nmod|particles induce|dobj|dissociation dissociation|amod|END_ENTITY	Reactive oxygen species generated from the mitochondrial electron transport chain induce cytochrome_c dissociation from beef-heart submitochondrial particles via cardiolipin peroxidation .
15209096	0	cardiolipin	128,139	cytochrome_c	23,35	cardiolipin	cytochrome c	MESH:D002308	54205	Chemical	Gene	influenced|nmod|START_ENTITY influenced|nsubjpass|Binding Binding|nmod|END_ENTITY	Binding and release of cytochrome_c in brain mitochondria is influenced by membrane potential and hydrophobic interactions with cardiolipin .
16690782	0	cardiolipin	14,25	cytochrome_c	39,51	cardiolipin	cytochrome c	MESH:D002308	54205	Chemical	Gene	oxidation|compound|START_ENTITY oxidation|nmod|END_ENTITY	Mechanisms of cardiolipin oxidation by cytochrome_c : relevance to pro- and antiapoptotic functions of etoposide .
18182042	0	cardiolipin	8,19	cytochrome_c	72,84	cardiolipin	cytochrome c	MESH:D002308	54205	Chemical	Gene	Loss|nmod|START_ENTITY favors|nsubj|Loss favors|dobj|release release|amod|END_ENTITY	Loss of cardiolipin in palmitate-treated GL15 glioblastoma cells favors cytochrome_c release from mitochondria leading to apoptosis .
1850290	0	cardiolipin	59,70	cytochrome_c	24,36	cardiolipin	cytochrome c	MESH:D002308	54205	Chemical	Gene	interaction|nmod|START_ENTITY END_ENTITY|nmod|interaction	Reversible unfolding of cytochrome_c upon interaction with cardiolipin bilayers .
1850291	0	cardiolipin	59,70	cytochrome_c	24,36	cardiolipin	cytochrome c	MESH:D002308	54205	Chemical	Gene	interaction|nmod|START_ENTITY END_ENTITY|nmod|interaction	Reversible unfolding of cytochrome_c upon interaction with cardiolipin bilayers .
18979502	0	cardiolipin	64,75	cytochrome_c	51,63	cardiolipin	cytochrome c	MESH:D002308	54205	Chemical	Gene	complexes|compound|START_ENTITY complexes|amod|END_ENTITY	Mitochondria-targeted disruptors and inhibitors of cytochrome_c / cardiolipin peroxidase complexes : a new strategy in anti-apoptotic drug discovery .
18983994	0	cardiolipin	30,41	cytochrome_c	45,57	cardiolipin	cytochrome c	MESH:D002308	54205	Chemical	Gene	fragmentation|nmod|START_ENTITY fragmentation|nmod|END_ENTITY	Free radical fragmentation of cardiolipin by cytochrome_c .
19053260	0	cardiolipin	132,143	cytochrome_c	61,73	cardiolipin	cytochrome c	MESH:D002308	54205	Chemical	Gene	complexes|dep|START_ENTITY design|dep|complexes design|nmod|END_ENTITY	Molecular design of new inhibitors of peroxidase activity of cytochrome_c / cardiolipin complexes : fluorescent oxadiazole-derivatized cardiolipin .
19053260	0	cardiolipin	74,85	cytochrome_c	61,73	cardiolipin	cytochrome c	MESH:D002308	54205	Chemical	Gene	complexes|compound|START_ENTITY design|dep|complexes design|nmod|END_ENTITY	Molecular design of new inhibitors of peroxidase activity of cytochrome_c / cardiolipin complexes : fluorescent oxadiazole-derivatized cardiolipin .
2171644	0	cardiolipin	49,60	cytochrome_c	25,37	cardiolipin	cytochrome c	MESH:D002308	54205	Chemical	Gene	oxidase|nmod|START_ENTITY oxidase|nsubj|Activation Activation|nmod|END_ENTITY	Activation of beef-heart cytochrome_c oxidase by cardiolipin and analogues of cardiolipin .
2171644	0	cardiolipin	78,89	cytochrome_c	25,37	cardiolipin	cytochrome c	MESH:D002308	54205	Chemical	Gene	cardiolipin|nmod|START_ENTITY oxidase|nmod|cardiolipin oxidase|nsubj|Activation Activation|nmod|END_ENTITY	Activation of beef-heart cytochrome_c oxidase by cardiolipin and analogues of cardiolipin .
22365930	0	cardiolipin	24,35	cytochrome_c	65,77	cardiolipin	cytochrome c	MESH:D002308	54205	Chemical	Gene	investigation|nmod|START_ENTITY acyl|nsubj|investigation acyl|dobj|site site|nmod|END_ENTITY	An investigation into a cardiolipin acyl chain insertion site in cytochrome_c .
24252639	0	cardiolipin	65,76	cytochrome_c	30,42	cardiolipin	cytochrome c	MESH:D002308	54205	Chemical	Gene	transformations|nmod|START_ENTITY transformations|nmod|END_ENTITY	Structural transformations of cytochrome_c upon interaction with cardiolipin .
24394851	0	cardiolipin	119,130	cytochrome_c	50,62	cardiolipin	cytochrome c	MESH:D002308	54205	Chemical	Gene	surface|nmod|START_ENTITY containing|nsubj|surface misfolds|advcl|containing END_ENTITY|acl|misfolds	Salt as a catalyst in the mitochondria : returning cytochrome_c to its native state after it misfolds on the surface of cardiolipin containing membranes .
25038566	0	cardiolipin	6,17	cytochrome_c	35,47	cardiolipin	cytochrome c	MESH:D002308	104968582	Chemical	Gene	essential|nsubj|START_ENTITY essential|nmod|translocation translocation|amod|END_ENTITY	Bound cardiolipin is essential for cytochrome_c oxidase proton translocation .
25485477	0	cardiolipin	67,78	cytochrome_c	54,66	cardiolipin	cytochrome c	MESH:D002308	104968582	Chemical	Gene	complex|compound|START_ENTITY complex|amod|END_ENTITY	Peroxidative permeabilization of liposomes induced by cytochrome_c / cardiolipin complex .
25627142	0	cardiolipin	34,45	cytochrome_c	12,24	cardiolipin	cytochrome c	MESH:D002308	54205	Chemical	Gene	oxidation|compound|START_ENTITY bound|nmod|oxidation ligation|amod|bound ligation|amod|END_ENTITY	Immobilized cytochrome_c bound to cardiolipin exhibits peculiar oxidation state-dependent axial heme ligation and catalytically reduces dioxygen .
8396450	0	cardiolipin	97,108	cytochrome_c	123,135	cardiolipin	cytochrome c	MESH:D002308	54205	Chemical	Gene	headgroup|nmod|START_ENTITY measurements|nmod|headgroup measurements|acl:relcl|bound bound|nmod|END_ENTITY	Dynamics in a protein-lipid complex : nuclear magnetic resonance measurements on the headgroup of cardiolipin when bound to cytochrome_c .
8630079	0	cardiolipin	77,88	cytochrome_c	45,57	cardiolipin	cytochrome c	MESH:D002308	54205	Chemical	Gene	presence|nmod|START_ENTITY linoleic_acid|nmod|presence linoleic_acid|nmod|END_ENTITY	Monoepoxide production from linoleic_acid by cytochrome_c in the presence of cardiolipin .
16814104	0	cardiolipin	28,39	cytochrome_c_oxidase	72,92	cardiolipin	cytochrome c oxidase	MESH:D002308	282199(Tax:9913)	Chemical	Gene	Contribution|nmod|START_ENTITY Contribution|nmod|END_ENTITY	Contribution of peroxidized cardiolipin to inactivation of bovine heart cytochrome_c_oxidase .
8389748	0	cardiolipin	22,33	cytochrome_c_oxidase	37,57	cardiolipin	cytochrome c oxidase	MESH:D002308	282199(Tax:9913)	Chemical	Gene	binding|nmod|START_ENTITY binding|acl|END_ENTITY	Functional binding of cardiolipin to cytochrome_c_oxidase .
19619503	0	cardiolipin	34,45	tafazzin	22,30	cardiolipin	tafazzin	MESH:D002308	6901	Chemical	Gene	metabolism|compound|START_ENTITY role|nmod|metabolism role|nmod|END_ENTITY	The enigmatic role of tafazzin in cardiolipin metabolism .
23523468	0	cardiolipin	110,121	tafazzin	143,151	cardiolipin	tafazzin	MESH:D002308	6901	Chemical	Gene	remodeling|compound|START_ENTITY remodeling|acl|linked linked|nmod|END_ENTITY	Barth_syndrome : cellular compensation of mitochondrial_dysfunction and apoptosis inhibition due to changes in cardiolipin remodeling linked to tafazzin -LRB- TAZ -RRB- gene mutation .
21121650	0	cardol_triene	48,61	tyrosinase	74,84	cardol triene	tyrosinase	CHEBI:52680	7299	Chemical	Gene	kinetics|nmod|START_ENTITY END_ENTITY|nsubj|kinetics	Irreversible competitive inhibitory kinetics of cardol_triene on mushroom tyrosinase .
24968890	0	carfilzomib	43,54	CPT-11	69,75	carfilzomib	CPT-11	MESH:C524865	963084(Tax:115711)	Chemical	Gene	effects|nmod|START_ENTITY combined|nsubj|effects combined|nmod|END_ENTITY	Enhanced anti-colorectal_cancer effects of carfilzomib combined with CPT-11 via downregulation of nuclear factor-kB in vitro and in vivo .
14693172	0	cariporide	31,41	CD62p	103,108	cariporide	CD62p	MESH:C093373	6403	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effects of the NHE-1 inhibitor cariporide alone or together with the P2Y12 antagonist AR-C 69331 MX on CD62p expression and formation of platelet-leukocyte aggregates .
17007739	0	cariporide	22,32	ICAM-1	62,68	cariporide	ICAM-1	MESH:C093373	3383	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|nmod|END_ENTITY	Inhibitory effects of cariporide on LPC-induced expression of ICAM-1 and adhesion of monocytes to smooth_muscle_cells in vitro .
14693172	0	cariporide	31,41	NHE-1	15,20	cariporide	NHE-1	MESH:C093373	6548	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|inhibitor inhibitor|compound|END_ENTITY	Effects of the NHE-1 inhibitor cariporide alone or together with the P2Y12 antagonist AR-C 69331 MX on CD62p expression and formation of platelet-leukocyte aggregates .
9950878	0	cariporide	35,45	NHE1	20,24	cariporide	NHE1	MESH:C093373	24782(Tax:10116)	Chemical	Gene	reduces|advmod|START_ENTITY reduces|nsubj|inhibitor inhibitor|amod|END_ENTITY	Orally administered NHE1 inhibitor cariporide reduces acute responses to coronary_occlusion and reperfusion .
21784521	0	cariporide	92,102	VEGF	154,158	cariporide	VEGF	MESH:C093373	7422	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|nmod|END_ENTITY	Inhibition of K562 leukemia angiogenesis and growth by selective Na + / H + exchanger inhibitor cariporide through down-regulation of pro-angiogenesis factor VEGF .
18599998	0	cariporide	11,21	bcl-2	43,48	cariporide	bcl-2	MESH:C093373	24224(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|genes genes|amod|END_ENTITY	-LSB- Effect of cariporide on the expression of bcl-2 and bax genes after neck heart transplantation from non heart-beating rats caused by warm ischemia -RSB- .
20868265	0	carmegliptin	73,85	dipeptidyl_peptidase_IV	39,62	carmegliptin	dipeptidyl peptidase IV	MESH:C552198	25253(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Pharmacokinetics Pharmacokinetics|nmod|inhibitor inhibitor|amod|END_ENTITY	Pharmacokinetics and metabolism of the dipeptidyl_peptidase_IV inhibitor carmegliptin in rats , dogs , and monkeys .
21900003	0	carminic_acid	42,55	catalase	79,87	carminic acid	catalase	MESH:C000386	847	Chemical	Gene	START_ENTITY|nmod|development development|nmod|END_ENTITY	Multiwalled carbon nanotubes dispersed in carminic_acid for the development of catalase based biosensor for selective amperometric determination of H -LRB- 2 -RRB- O -LRB- 2 -RRB- and iodate .
14506174	0	carmustine	48,58	O6-Methylguanine-DNA_methyltransferase	101,139	carmustine	O6-Methylguanine-DNA methyltransferase	MESH:D002330	17314(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|inactivation inactivation|nmod|END_ENTITY	Sensitization of pancreatic_tumor xenografts to carmustine and temozolomide by inactivation of their O6-Methylguanine-DNA_methyltransferase with O6-benzylguanine or O6-benzyl-2 ' - deoxyguanosine .
1586984	0	carmustine	31,41	tumour_necrosis_factor	71,93	carmustine	tumour necrosis factor	MESH:D002330	7124	Chemical	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	A randomised phase II study of carmustine alone or in combination with tumour_necrosis_factor in patients with advanced melanoma .
10545096	0	carnitine	175,184	Agp2p	198,203	carnitine	Agp2p	MESH:D002331	852429(Tax:4932)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Molecular characterization of carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria in Saccharomyces_cerevisiae and identification of a plasma membrane carnitine transporter , Agp2p .
12015320	0	carnitine	69,78	CPT1B	42,47	carnitine	CPT1B	MESH:D002331	1375	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Structural and functional genomics of the CPT1B gene for muscle-type carnitine palmitoyltransferase I in mammals .
23566841	0	carnitine	86,95	CPT1B	34,39	carnitine	CPT1B	MESH:D002331	1375	Chemical	Gene	levels|compound|START_ENTITY nucleotide|nmod|levels nucleotide|nmod|genes genes|compound|END_ENTITY	Single nucleotide polymorphism in CPT1B and CPT2 genes and its association with blood carnitine levels in acute_myocardial_infarction patients .
26058865	0	carnitine	76,85	CPT1B	111,116	carnitine	CPT1B	MESH:D002331	1375	Chemical	Gene	response|nmod|START_ENTITY palmitoyltransferase|nsubj|response palmitoyltransferase|dobj|gene gene|compound|END_ENTITY	Differential epigenetic and transcriptional response of the skeletal muscle carnitine palmitoyltransferase 1B -LRB- CPT1B -RRB- gene to lipid exposure with obesity .
9199240	0	carnitine	79,88	CPT1B	52,57	carnitine	CPT1B	MESH:D002331	1375	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Localization and intron usage analysis of the human CPT1B gene for muscle type carnitine palmitoyltransferase I .
9633746	0	carnitine	14,23	CSF	0,3	carnitine	CSF	MESH:D002331	1437	Chemical	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	CSF levels of carnitine in children with meningitis , neurologic_disorders , acute_gastroenteritis , and seizure .
10525100	0	carnitine	16,25	OCTN2	67,72	carnitine	OCTN2	MESH:D002331	6584	Chemical	Gene	transport|amod|START_ENTITY transport|nmod|transporter transporter|appos|END_ENTITY	Na -LRB- + -RRB- - dependent carnitine transport by organic cation transporter -LRB- OCTN2 -RRB- : its pharmacological and toxicological relevance .
10544029	0	carnitine	116,125	OCTN2	46,51	carnitine	OCTN2	MESH:D002331	6584	Chemical	Gene	uptake|amod|START_ENTITY restoration|nmod|uptake protein|dep|restoration protein|compound|END_ENTITY	GFP-Human high-affinity carnitine transporter OCTN2 protein : subcellular localization and functional restoration of carnitine uptake in mutant cell lines with the carnitine transporter defect .
10544029	0	carnitine	163,172	OCTN2	46,51	carnitine	OCTN2	MESH:D002331	6584	Chemical	Gene	defect|amod|START_ENTITY lines|nmod|defect uptake|nmod|lines restoration|nmod|uptake protein|dep|restoration protein|compound|END_ENTITY	GFP-Human high-affinity carnitine transporter OCTN2 protein : subcellular localization and functional restoration of carnitine uptake in mutant cell lines with the carnitine transporter defect .
10544029	0	carnitine	24,33	OCTN2	46,51	carnitine	OCTN2	MESH:D002331	6584	Chemical	Gene	protein|amod|START_ENTITY protein|compound|END_ENTITY	GFP-Human high-affinity carnitine transporter OCTN2 protein : subcellular localization and functional restoration of carnitine uptake in mutant cell lines with the carnitine transporter defect .
10545605	0	carnitine	28,37	OCTN2	50,55	carnitine	OCTN2	MESH:D002331	6584	Chemical	Gene	transporter|amod|START_ENTITY epidemiology|nmod|transporter END_ENTITY|nsubj|epidemiology	Genetic epidemiology of the carnitine transporter OCTN2 gene in a Japanese population and phenotypic characterization in Japanese pedigrees with primary systemic carnitine_deficiency .
10679939	0	carnitine	63,72	OCTN2	27,32	carnitine	OCTN2	MESH:D002331	6584	Chemical	Gene	activity|compound|START_ENTITY associated|nmod|activity associated|nsubj|mutation mutation|nmod|gene gene|compound|END_ENTITY	A missense mutation in the OCTN2 gene associated with residual carnitine transport activity .
11739607	0	carnitine	24,33	OCTN2	46,51	carnitine	OCTN2	MESH:D002331	29726(Tax:10116)	Chemical	Gene	transporter|amod|START_ENTITY relevance|nmod|transporter END_ENTITY|nsubj|relevance	Functional relevance of carnitine transporter OCTN2 to brain distribution of L-carnitine and acetyl-L-carnitine across the blood-brain barrier .
12084797	0	carnitine	89,98	OCTN2	117,122	carnitine	OCTN2	MESH:D002331	20520(Tax:10090)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Age-associated cardiomyopathy in heterozygous carrier mice of a pathological mutation of carnitine transporter gene , OCTN2 .
12210323	0	carnitine	65,74	OCTN2	6,11	carnitine	OCTN2	MESH:D002331	6584	Chemical	Gene	therapy|compound|START_ENTITY prevents|nsubj|therapy mutations|parataxis|prevents mutations|compound|END_ENTITY	Novel OCTN2 mutations : no genotype-phenotype correlations : early carnitine therapy prevents cardiomyopathy .
12802501	0	carnitine	18,27	OCTN2	76,81	carnitine	OCTN2	MESH:D002331	6584	Chemical	Gene	acyltransferases|amod|START_ENTITY Downregulation|nmod|acyltransferases END_ENTITY|nsubj|Downregulation	Downregulation of carnitine acyltransferases and organic cation transporter OCTN2 in mononuclear cells in healthy elderly and patients with myelodysplastic_syndromes .
14665638	0	carnitine	50,59	OCTN2	77,82	carnitine	OCTN2	MESH:D002331	6584	Chemical	Gene	transport|amod|START_ENTITY transport|nmod|transporter transporter|compound|END_ENTITY	Tyrosine residues affecting sodium stimulation of carnitine transport in the OCTN2 carnitine/organic cation transporter .
15125318	0	carnitine	17,26	OCTN2	11,16	carnitine	OCTN2	MESH:D002331	6584	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	-LSB- The human OCTN2 carnitine transporter and its mutations -RSB- .
15499185	0	carnitine	85,94	OCTN2	59,64	carnitine	OCTN2	MESH:D002331	6584	Chemical	Gene	recognition|amod|START_ENTITY roles|nmod|recognition regions|dep|roles regions|nmod|END_ENTITY	Functional regions of organic cation/carnitine transporter OCTN2 -LRB- SLC22A5 -RRB- : roles in carnitine recognition .
16754783	0	carnitine	72,81	OCTN2	37,42	carnitine	OCTN2	MESH:D002331	20520(Tax:10090)	Chemical	Gene	transport|amod|START_ENTITY responsible|nmod|transport responsible|nsubj|END_ENTITY	Organic cation/carnitine transporter OCTN2 -LRB- Slc22a5 -RRB- is responsible for carnitine transport across apical membranes of small intestinal epithelial cells in mouse .
16839516	0	carnitine	81,90	OCTN2	104,109	carnitine	OCTN2	MESH:D002331	29726(Tax:10116)	Chemical	Gene	transporter|amod|START_ENTITY characterization|nmod|transporter characterization|appos|END_ENTITY	Cloning and functional characterization of a novel up-regulator , cartregulin , of carnitine transporter , OCTN2 .
16928358	0	carnitine	93,102	OCTN2	116,121	carnitine	OCTN2	MESH:D002331	6584	Chemical	Gene	transporter|amod|START_ENTITY drugs|nmod|transporter effect|nmod|drugs Mechanism|nmod|effect Mechanism|appos|END_ENTITY	Mechanism of the inhibitory effect of zwitterionic drugs -LRB- levofloxacin and grepafloxacin -RRB- on carnitine transporter -LRB- OCTN2 -RRB- in Caco-2 cells .
17509700	0	carnitine	55,64	OCTN2	192,197	carnitine	OCTN2	MESH:D002331	6584	Chemical	Gene	transport|dobj|START_ENTITY transport|nmod|reticulum reticulum|acl|caused caused|nmod|insertion insertion|nmod|amino_acids amino_acids|nmod|loop loop|nmod|END_ENTITY	OCTN2VT , a splice variant of OCTN2 , does not transport carnitine because of the retention in the endoplasmic reticulum caused by insertion of 24 amino_acids in the first extracellular loop of OCTN2 .
17509700	0	carnitine	55,64	OCTN2	29,34	carnitine	OCTN2	MESH:D002331	6584	Chemical	Gene	transport|dobj|START_ENTITY transport|nsubj|OCTN2VT OCTN2VT|appos|variant variant|nmod|END_ENTITY	OCTN2VT , a splice variant of OCTN2 , does not transport carnitine because of the retention in the endoplasmic reticulum caused by insertion of 24 amino_acids in the first extracellular loop of OCTN2 .
17703373	0	carnitine	18,27	OCTN2	41,46	carnitine	OCTN2	MESH:D002331	6584	Chemical	Gene	transporter|amod|START_ENTITY Deficiency|nmod|transporter Deficiency|appos|END_ENTITY	Deficiency of the carnitine transporter -LRB- OCTN2 -RRB- with partial N-acetylglutamate_synthase -LRB- NAGS -RRB- deficiency .
17977516	0	carnitine	66,75	OCTN2	50,55	carnitine	OCTN2	MESH:D002331	6584	Chemical	Gene	uptake|nmod|START_ENTITY uptake|nummod|END_ENTITY	Contributions of phosphorylation to regulation of OCTN2 uptake of carnitine are minimal in BeWo cells .
18574325	0	carnitine	101,110	OCTN2	52,57	carnitine	OCTN2	MESH:D002331	20520(Tax:10090)	Chemical	Gene	distribution|nmod|START_ENTITY transporter|nmod|distribution transporter|dobj|SLC22A5 SLC22A5|compound|END_ENTITY	Involvement of carnitine/organic cation transporter OCTN2 -LRB- SLC22A5 -RRB- in distribution of its substrate carnitine to the heart .
19041296	0	carnitine	34,43	OCTN2	57,62	carnitine	OCTN2	MESH:D002331	6584	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Inactivation by omeprazole of the carnitine transporter -LRB- OCTN2 -RRB- reconstituted in liposomes .
20219053	0	carnitine	25,34	OCTN2	0,5	carnitine	OCTN2	MESH:D002331	29726(Tax:10116)	Chemical	Gene	capacity|amod|START_ENTITY associated|nmod|capacity associated|nsubjpass|END_ENTITY	OCTN2 is associated with carnitine transport capacity of rat skeletal muscles .
20303936	0	carnitine	11,20	OCTN2	51,56	carnitine	OCTN2	MESH:D002331	29726(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY regulates|nsubj|concentration regulates|dobj|expression expression|compound|END_ENTITY	The plasma carnitine concentration regulates renal OCTN2 expression and carnitine transport in rats .
20858838	0	carnitine	50,59	OCTN2	36,41	carnitine	OCTN2	MESH:D002331	20520(Tax:10090)	Chemical	Gene	wasting|amod|START_ENTITY affects|dobj|wasting affects|nsubj|downregulation downregulation|nmod|END_ENTITY	Cisplatin-induced downregulation of OCTN2 affects carnitine wasting .
21126579	0	carnitine	27,36	OCTN2	21,26	carnitine	OCTN2	MESH:D002331	6584	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Glycosylation of the OCTN2 carnitine transporter : study of natural mutations identified in patients with primary carnitine_deficiency .
22310714	0	carnitine	29,38	OCTN2	67,72	carnitine	OCTN2	MESH:D002331	29726(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|uptake uptake|nmod|translocation translocation|nmod|END_ENTITY	Muscle contraction increases carnitine uptake via translocation of OCTN2 .
22310714	6	carnitine	720,729	OCTN2	767,772	carnitine	OCTN2	MESH:D002331	29726(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY involves|nsubj|uptake involves|dobj|translocation translocation|nmod|END_ENTITY	To test the hypothesis that increased carnitine uptake involves the translocation of OCTN2 , contraction-induced alteration in the subcellular localization of OCTN2 was examined .
22900493	0	carnitine	24,33	OCTN2	18,23	carnitine	OCTN2	MESH:D002331	6584	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Inhibition of the OCTN2 carnitine transporter by HgCl2 and methylmercury in the proteoliposome experimental model : insights in the mechanism of toxicity .
9837751	0	carnitine	55,64	OCTN2	29,34	carnitine	OCTN2	MESH:D002331	20520(Tax:10090)	Chemical	Gene	cotransporter|compound|START_ENTITY END_ENTITY|appos|cotransporter	A missense mutation of mouse OCTN2 , a sodium-dependent carnitine cotransporter , in the juvenile_visceral_steatosis mouse .
16288981	0	carnitine	42,51	OCTN3	0,5	carnitine	OCTN3	MESH:D002331	100049579	Chemical	Gene	transporter|compound|START_ENTITY transporter|nsubj|END_ENTITY	OCTN3 is a mammalian peroxisomal membrane carnitine transporter .
17065219	0	carnitine	86,95	Octn2	32,37	carnitine	Octn2	MESH:D002331	29726(Tax:10116)	Chemical	Gene	depletion|amod|START_ENTITY induces|dobj|depletion induces|nsubj|END_ENTITY	Experimental colitis : decreased Octn2 and Atb0 + expression in rat colonocytes induces carnitine depletion that is reversible by carnitine-loaded liposomes .
8538177	0	carnitine	81,90	carnitine_palmitoyltransferase_I	29,61	carnitine	carnitine palmitoyltransferase I	MESH:D002331	25756(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY END_ENTITY|dobj|concentration	Alterations of remnant liver carnitine_palmitoyltransferase_I activity and serum carnitine concentration after partial hepatectomy in rats .
16051193	0	carnitine	30,39	octn3	53,58	carnitine	octn3	MESH:D002331	56517(Tax:10090)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Regulation of testis-specific carnitine transporter -LRB- octn3 -RRB- gene by proximal cis-acting elements Sp1 in mice .
3416821	0	carnitine	60,69	prolactin	11,20	carnitine	prolactin	MESH:D002331	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of prolactin and growth_hormone on tissue and serum carnitine in the rat .
22531045	0	carnosic_acid	88,101	cytochrome_P450	28,43	carnosic acid	cytochrome P450	MESH:C018381	4051	Chemical	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	In vitro hepatotoxicity and cytochrome_P450 induction and inhibition characteristics of carnosic_acid , a dietary supplement with antiadipogenic properties .
23657886	0	carnosine	59,68	monoamine_oxidase-A	9,28	carnosine	monoamine oxidase-A	MESH:D002336	29253(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY activity|dep|effect activity|amod|END_ENTITY	Platelet monoamine_oxidase-A activity and aging : effect of carnosine .
15102049	0	carnosine	10,19	runt-related_transcription_factor-2	23,58	carnosine	runt-related transcription factor-2	MESH:D002336	860	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|END_ENTITY	Effect of carnosine on runt-related_transcription_factor-2 / core binding factor alpha-1 and Sox9 expressions of human periodontal ligament cells .
25405290	0	carnosol	35,43	TRPA1	55,60	carnosol	TRPA1	MESH:C068623	8989	Chemical	Gene	START_ENTITY|nmod|agonist agonist|compound|END_ENTITY	Identification of natural compound carnosol as a novel TRPA1 receptor agonist .
14688281	0	carnosol	175,183	heme_oxygenase-1	14,30	carnosol	heme oxygenase-1	MESH:C068623	15368(Tax:10090)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of heme_oxygenase-1 expression through the phosphatidylinositol_3-kinase / Akt pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol .
19797823	0	carperitide	10,21	adiponectin	32,43	carperitide	adiponectin	MESH:C472955	9370	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|compound|END_ENTITY	Effect of carperitide on plasma adiponectin levels in acute_decompensated_heart_failure patients with diabetes_mellitus .
9829404	0	carprofen	71,80	cyclooxygenase_1_and_2	45,67	carprofen	cyclooxygenase 1 and 2	MESH:C007005	403544;442942	Chemical	Gene	Evaluation|nmod|START_ENTITY Evaluation|nmod|END_ENTITY	Evaluation of selective inhibition of canine cyclooxygenase_1_and_2 by carprofen and other nonsteroidal anti-inflammatory drugs .
10095048	0	carrageenin	74,85	c-Fos	93,98	carrageenin	c-Fos	MESH:D002351	314322(Tax:10116)	Chemical	Gene	morphine|nmod|START_ENTITY effects|nmod|morphine antagonists|nmod|effects Effects|nmod|antagonists evoked|nsubj|Effects evoked|dobj|expression expression|amod|END_ENTITY	Effects of opioid receptor antagonists on the effects of i.v. morphine on carrageenin evoked c-Fos expression in the superficial dorsal horn of the rat spinal cord .
8762093	0	carrageenin	67,78	c-Fos	39,44	carrageenin	c-Fos	MESH:D002351	314322(Tax:10116)	Chemical	Gene	inflammation|compound|START_ENTITY induced|nmod|inflammation expression|acl|induced expression|amod|END_ENTITY	Intraplantar morphine depresses spinal c-Fos expression induced by carrageenin inflammation but not by noxious heat .
8821738	0	carrageenin	68,79	c-Fos	94,99	carrageenin	c-Fos	MESH:D002351	314322(Tax:10116)	Chemical	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	When is the maximal effect of pre-administered systemic morphine on carrageenin evoked spinal c-Fos expression in the rat ?
9200179	0	carrageenin	134,145	c-Fos	189,194	carrageenin	c-Fos	MESH:D002351	314322(Tax:10116)	Chemical	Gene	treatment|nmod|START_ENTITY treatment|acl|induced induced|dobj|expression expression|compound|END_ENTITY	Chronic treatment with systemic morphine induced tolerance to the systemic and peripheral antinociceptive effects of morphine on both carrageenin induced mechanical_hyperalgesia and spinal c-Fos expression in awake rats .
9342584	0	carteolol	14,23	cytochrome_P450	48,63	carteolol	cytochrome P450	MESH:D002354	4051	Chemical	Gene	Metabolism|nmod|START_ENTITY Metabolism|nmod|END_ENTITY	Metabolism of carteolol by cDNA-expressed human cytochrome_P450 .
25660493	0	carvedilol	14,24	B-type_natriuretic_Peptide	28,54	carvedilol	B-type natriuretic Peptide	MESH:C043211	4879	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|function function|amod|END_ENTITY	The effect of carvedilol on B-type_natriuretic_Peptide and cardiac function in patients with heart_failure and persistent atrial_fibrillation .
15325927	0	carvedilol	11,21	B-type_natriuretic_peptide	32,58	carvedilol	B-type natriuretic peptide	MESH:C043211	4879	Chemical	Gene	Effects|nmod|START_ENTITY concentration|nsubj|Effects concentration|amod|END_ENTITY	Effects of carvedilol on plasma B-type_natriuretic_peptide concentration and symptoms in patients with heart_failure and preserved ejection fraction .
11164846	0	carvedilol	20,30	HERG	40,44	carvedilol	HERG	MESH:C043211	3757	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Antiarrhythmic drug carvedilol inhibits HERG potassium channels .
10571255	0	carvedilol	40,50	P-glycoprotein	65,79	carvedilol	P-glycoprotein	MESH:C043211	5243	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|activity activity|amod|END_ENTITY	Increase in doxorubicin cytotoxicity by carvedilol inhibition of P-glycoprotein activity .
19762071	0	carvedilol	11,21	PAI-1	39,44	carvedilol	PAI-1	MESH:C043211	5054	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of carvedilol or metoprolol on PAI-1 , tPA-mass concentration or Von_Willebrand_factor in chronic_heart_failure -- a COMET substudy .
15932730	0	carvedilol	15,25	PDCD5	44,49	carvedilol	PDCD5	MESH:C043211	9141	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	-LSB- The effect of carvedilol on apoptosis gene PDCD5 expression in chronic heart_failure patients -RSB- .
17978490	0	carvedilol	38,48	UGT1A1	52,58	carvedilol	UGT1A1	MESH:C043211	54658	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|nmod|END_ENTITY	Stereoselective metabolism of racemic carvedilol by UGT1A1 and UGT2B7 , and effects of mutation of these enzymes on glucuronidation activity .
19367012	0	carvedilol	10,20	adiponectin	31,42	carvedilol	adiponectin	MESH:C043211	9370	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|concentration concentration|compound|END_ENTITY	Effect of carvedilol on plasma adiponectin concentration in patients with chronic_heart_failure .
15182772	0	carvedilol	22,32	angiotensin-converting_enzyme	36,65	carvedilol	angiotensin-converting enzyme	MESH:C043211	1636	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activity activity|amod|END_ENTITY	Beneficial effects of carvedilol on angiotensin-converting_enzyme activity and renin plasma levels in patients with chronic_heart_failure .
9816692	0	carvedilol	12,22	beta_1	24,30	carvedilol	beta 1	MESH:C043211	3779	Chemical	Gene	Effects|nmod|START_ENTITY Effects|dep|END_ENTITY	-LSB- Effects of carvedilol -LRB- beta_1 , beta_2 , alpha_1 bloker -RRB- on refractory congestive heart_failure -RSB- .
14692707	0	carvedilol	6,16	brain_natriuretic_peptide	68,93	carvedilol	brain natriuretic peptide	MESH:C043211	4879	Chemical	Gene	concentration|amod|START_ENTITY END_ENTITY|nsubj|concentration	Serum carvedilol concentration and its relation to change in plasma brain_natriuretic_peptide level in the treatment of heart_failure : a preliminary study .
17379986	0	carvedilol	56,66	brain_natriuretic_peptide	18,43	carvedilol	brain natriuretic peptide	MESH:C043211	4879	Chemical	Gene	therapy|amod|START_ENTITY END_ENTITY|nmod|therapy	Decline of plasma brain_natriuretic_peptide level after carvedilol therapy to treat dilated_cardiomyopathy presenting with mechanical alternans .
20058503	0	carvedilol	89,99	brain_natriuretic_peptide	19,44	carvedilol	brain natriuretic peptide	MESH:C043211	4879	Chemical	Gene	therapy|amod|START_ENTITY start|nmod|therapy phase|nmod|start level|nmod|phase level|compound|END_ENTITY	Decrease in plasma brain_natriuretic_peptide level in the early phase after the start of carvedilol therapy is a novel predictor of long-term outcome in patients with chronic_heart_failure .
24225056	0	carvedilol	11,21	cAMP_response_element_binding_protein	43,80	carvedilol	cAMP response element binding protein	MESH:C043211	12912(Tax:10090)	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|expression expression|compound|END_ENTITY	Effects of carvedilol treatment on cardiac cAMP_response_element_binding_protein expression and phosphorylation in acute coxsackievirus B3-induced myocarditis .
16598518	0	carvedilol	28,38	insulin	48,55	carvedilol	insulin	MESH:C043211	3630	Chemical	Gene	improves|nsubj|START_ENTITY improves|dobj|resistance resistance|compound|END_ENTITY	After myocardial_infarction carvedilol improves insulin resistance compared to metoprolol .
12048901	0	carvedilol	11,21	interleukin-6	42,55	carvedilol	interleukin-6	MESH:C043211	3569	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|nmod|END_ENTITY	Effects of carvedilol on plasma levels of interleukin-6 and tumor_necrosis_factor-alpha in nine patients with dilated_cardiomyopathy .
19333555	0	carvedilol	110,120	thrombomodulin	81,95	carvedilol	thrombomodulin	MESH:C043211	7056	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	The inhibition in tumor_necrosis_factor-alpha-induced attenuation in endothelial thrombomodulin expression by carvedilol is mediated by nuclear factor-kappaB and reactive oxygen species .
24130379	0	carvedilol	10,20	toll-like_receptor_4	100,120	carvedilol	toll-like receptor 4	MESH:C043211	29260(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|role role|nmod|END_ENTITY	Effect of carvedilol on cardiomyocyte apoptosis in a rat model of myocardial_infarction : a role for toll-like_receptor_4 .
23884833	0	carvedilol	10,20	toll-like_receptor_4_and_b-arrestin_2	96,133	carvedilol	toll-like receptor 4 and b-arrestin 2	MESH:C043211	29260(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|role role|nmod|END_ENTITY	Effect of carvedilol on cardiac_dysfunction 4 days after myocardial_infarction in rats : role of toll-like_receptor_4_and_b-arrestin_2 .
11158761	0	caspofungin	62,73	MK-0991	75,82	caspofungin	MK-0991	MESH:C105417	1477092(Tax:190192)	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY pharmacokinetics|appos|END_ENTITY	Compartmental pharmacokinetics of the antifungal echinocandin caspofungin -LRB- MK-0991 -RRB- in rabbits .
23513727	0	cassiamin_A	41,52	Pancreatic_lipase	0,17	cassiamin A	Pancreatic lipase	MESH:C580699	5406	Chemical	Gene	activity|nmod|START_ENTITY END_ENTITY|dobj|activity	Pancreatic_lipase inhibitory activity of cassiamin_A , a bianthraquinone from Cassia siamea .
24584634	0	catalpol	11,19	ATPase	23,29	catalpol	ATPase	MESH:C078040	1769	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of catalpol on ATPase and amino_acids in gerbils with cerebral_ischemia / reperfusion injury .
21749830	0	catalpol	77,85	transforming_growth_factor-b1	89,118	catalpol	transforming growth factor-b1	MESH:C078040	7040	Chemical	Gene	START_ENTITY|nmod|pathway pathway|amod|END_ENTITY	-LSB- Effects of Chinese herbal medicine Liuwei Dihuang Pill and its main monomer catalpol on transforming_growth_factor-b1 / Smad pathway in HK-2 cells -RSB- .
25102179	0	catarrhines	50,61	MOXD2	36,41	catarrhines	MOXD2	null	100289017	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Frequent loss and alteration of the MOXD2 gene in catarrhines and whales : a possible connection with the evolution of olfaction .
11368631	0	catechin	6,14	Fc_epsilon_RI	75,88	catechin	Fc epsilon RI	MESH:D002392	2205	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|nmod|END_ENTITY	A tea catechin suppresses the expression of the high-affinity IgE receptor Fc_epsilon_RI in human basophilic KU812 cells .
22704779	0	catechin	21,29	VEGF	76,80	catechin	VEGF	MESH:D002392	7422	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|levels levels|compound|END_ENTITY	Different effects of catechin on angiogenesis and inflammation depending on VEGF levels .
18533286	0	catechin	10,18	cholesterol_7alpha-hydroxylase	28,58	catechin	cholesterol 7alpha-hydroxylase	MESH:D002392	1581	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Green tea catechin enhances cholesterol_7alpha-hydroxylase gene expression in HepG2 cells .
16217757	0	catechin	10,18	vascular_endothelial_growth_factor	57,91	catechin	vascular endothelial growth factor	MESH:D002392	7422	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|signaling signaling|nsubj|END_ENTITY	Green tea catechin , epigallocatechin-3-gallate , inhibits vascular_endothelial_growth_factor angiogenic signaling by disrupting the formation of a receptor complex .
26233863	0	catechins	42,51	C-reactive_protein	62,80	catechins	C-reactive protein	CHEBI:23053	1401	Chemical	Gene	START_ENTITY|nmod|concentrations concentrations|amod|END_ENTITY	Effects of supplementation with green tea catechins on plasma C-reactive_protein concentrations : A systematic review and meta-analysis of randomized controlled trials .
17228868	0	catechins	10,19	DNA_gyrase	38,48	catechins	DNA gyrase	CHEBI:23053	7153	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|END_ENTITY	Green tea catechins inhibit bacterial DNA_gyrase by interaction with its ATP binding site .
23840454	0	catechins	43,52	FLT3	56,60	catechins	FLT3	CHEBI:23053	2322	Chemical	Gene	START_ENTITY|nmod|cells cells|nummod|END_ENTITY	Inhibition of FLT3 expression by green tea catechins in FLT3 mutated-AML cells .
15340218	0	catechins	18,27	IL-12p40	35,43	catechins	IL-12p40	CHEBI:23053	16160(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|production production|compound|END_ENTITY	Effect of various catechins on the IL-12p40 production by murine peritoneal macrophages and a macrophage cell line , J774 .1 .
11470492	0	catechins	24,33	cytochrome_P450	85,100	catechins	cytochrome P450	CHEBI:23053	4051	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition by green tea catechins of metabolic activation of procarcinogens by human cytochrome_P450 .
18537694	0	catechins	55,64	insulin	76,83	catechins	insulin	CHEBI:23053	3630	Chemical	Gene	START_ENTITY|xcomp|improve improve|dobj|resistance resistance|compound|END_ENTITY	Mechanisms underlying beneficial health effects of tea catechins to improve insulin resistance and endothelial_dysfunction .
12801907	0	catechins	32,41	matrix_metalloproteinase_7	67,93	catechins	matrix metalloproteinase 7	CHEBI:23053	4316	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	Inhibitory effects of green tea catechins on the activity of human matrix_metalloproteinase_7 -LRB- matrilysin -RRB- .
21821933	0	catechins	106,115	matrix_metalloproteinase_7	49,75	catechins	matrix metalloproteinase 7	CHEBI:23053	4316	Chemical	Gene	activity|nmod|START_ENTITY Analysis|dep|activity Analysis|nmod|mechanism mechanism|nmod|inhibition inhibition|nmod|END_ENTITY	Analysis of the mechanism of inhibition of human matrix_metalloproteinase_7 -LRB- MMP-7 -RRB- activity by green tea catechins .
11559542	0	catechol_estrogens	59,77	Catechol-O-methyltransferase	0,28	catechol estrogens	Catechol-O-methyltransferase	MESH:D002393	1312	Chemical	Gene	metabolism|nmod|START_ENTITY END_ENTITY|dep|metabolism	Catechol-O-methyltransferase -LRB- COMT -RRB- - mediated metabolism of catechol_estrogens : comparison of wild-type and variant COMT isoforms .
3033538	0	catechol_estrogens	10,28	prolactin	32,41	catechol estrogens	prolactin	MESH:D002393	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Effect of catechol_estrogens on prolactin secretion in the rat : lack of correlation with estrogenic activity .
27508	0	catechol_estrogens	54,72	tyrosine_hydroxylase	21,41	catechol estrogens	tyrosine hydroxylase	MESH:D002393	7054	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|activity activity|amod|END_ENTITY	Direct inhibition of tyrosine_hydroxylase activity by catechol_estrogens .
7066709	0	catecholamine	39,52	Acetylcholinesterase	0,20	catecholamine	Acetylcholinesterase	CHEBI:33567	83817(Tax:10116)	Chemical	Gene	neurons|amod|START_ENTITY END_ENTITY|nmod|neurons	Acetylcholinesterase in pontomedullary catecholamine neurons of the adult albino rat .
16079252	0	catecholamine	21,34	Activin_A	0,9	catecholamine	Activin A	CHEBI:33567	29200(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Activin_A stimulates catecholamine secretion from rat adrenal chromaffin cells : a new physiological mechanism .
12609750	0	catecholamine	24,37	Angiotensin_II	0,14	catecholamine	Angiotensin II	CHEBI:33567	183	Chemical	Gene	secretion|amod|START_ENTITY mediates|dobj|secretion mediates|nsubj|END_ENTITY	Angiotensin_II mediates catecholamine and neuropeptide_Y secretion in human adrenal chromaffin cells through the AT1 receptor .
729647	0	catecholamine	36,49	Angiotensin_II	0,14	catecholamine	Angiotensin II	CHEBI:33567	183	Chemical	Gene	secretion|compound|START_ENTITY mediation|nmod|secretion mediation|compound|END_ENTITY	Angiotensin_II mediation of adrenal catecholamine secretion induced by intrarenal isoprenaline infusion .
17194738	0	catecholamine	80,93	Corticotropin-releasing_factor	0,30	catecholamine	Corticotropin-releasing factor	CHEBI:33567	1392	Chemical	Gene	secretion|amod|START_ENTITY regulate|dobj|secretion regulate|nsubj|END_ENTITY	Corticotropin-releasing_factor -LRB- CRF -RRB- and the urocortins differentially regulate catecholamine secretion in human and rat adrenals , in a CRF receptor type-specific manner .
7678287	0	catecholamine	42,55	Corticotropin-releasing_factor	0,30	catecholamine	Corticotropin-releasing factor	CHEBI:33567	81648(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|stimulates stimulates|compound|END_ENTITY	Corticotropin-releasing_factor stimulates catecholamine release in hypothalamus and prefrontal cortex in freely moving rats as assessed by microdialysis .
12617949	0	catecholamine	79,92	Corticotropin-releasing_hormone	0,31	catecholamine	Corticotropin-releasing hormone	CHEBI:33567	81648(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY alter|dobj|release fails|xcomp|alter fails|nsubj|blockade blockade|amod|END_ENTITY	Corticotropin-releasing_hormone receptor blockade fails to alter stress-evoked catecholamine release in prefrontal cortex of control or chronically stressed rats .
9808618	0	catecholamine	67,80	EPAS1	44,49	catecholamine	EPAS1	CHEBI:33567	13819(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY essential|nmod|homeostasis essential|nsubj|END_ENTITY	The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart_failure during embryonic development .
1589148	0	catecholamine	39,52	Endothelin-3	0,12	catecholamine	Endothelin-3	CHEBI:33567	366270(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Endothelin-3 stimulates the release of catecholamine from cortical and striatal slices of the rat .
12665315	0	catecholamine	21,34	Ghrelin	10,17	catecholamine	Ghrelin	CHEBI:33567	59301(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY Effect|nmod|secretion Effect|nmod|END_ENTITY	Effect of Ghrelin on catecholamine secretion in rat pheochromocytoma PC12 cells .
21368060	0	catecholamine	49,62	Ghrelin	0,7	catecholamine	Ghrelin	CHEBI:33567	58991(Tax:10090)	Chemical	Gene	neurons|amod|START_ENTITY activation|nmod|neurons inhibits|dobj|activation inhibits|nsubj|END_ENTITY	Ghrelin inhibits visceral afferent activation of catecholamine neurons in the solitary tract nucleus .
8292052	0	catecholamine	35,48	IL-1_beta	22,31	catecholamine	IL-1 beta	CHEBI:33567	281251(Tax:9913)	Chemical	Gene	secretion|amod|START_ENTITY END_ENTITY|nmod|secretion	Stimulatory effect of IL-1_beta on catecholamine secretion from cultured bovine adrenal medullary cells .
2459120	0	catecholamine	22,35	Insulin	0,7	catecholamine	Insulin	CHEBI:33567	3630	Chemical	Gene	stimulation|amod|START_ENTITY antagonism|nmod|stimulation antagonism|compound|END_ENTITY	Insulin antagonism of catecholamine stimulation of fatty_acid transport in the adipocyte .
10425201	0	catecholamine	27,40	Leptin	0,6	catecholamine	Leptin	CHEBI:33567	16846(Tax:10090)	Chemical	Gene	secretion|amod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Leptin directly stimulates catecholamine secretion and synthesis in cultured porcine adrenal medullary chromaffin cells .
11606454	0	catecholamine	18,31	Leptin	0,6	catecholamine	Leptin	CHEBI:33567	16846(Tax:10090)	Chemical	Gene	synthesis|amod|START_ENTITY stimulates|dobj|synthesis stimulates|nsubj|END_ENTITY	Leptin stimulates catecholamine synthesis in a PKC-dependent manner in cultured porcine adrenal medullary chromaffin cells .
14624411	0	catecholamine	52,65	Leptin	0,6	catecholamine	Leptin	CHEBI:33567	25608(Tax:10116)	Chemical	Gene	responsiveness|amod|START_ENTITY alter|dobj|responsiveness alter|nsubj|administration administration|compound|END_ENTITY	Leptin administration to normal rats does not alter catecholamine responsiveness to insulin-induced hypoglycemia .
2764985	6	catecholamine	1158,1171	ML-9	1144,1148	catecholamine	MLCK	CHEBI:33567	338037(Tax:9913)	Chemical	Gene	secretion|amod|START_ENTITY inhibits|dobj|secretion inhibits|nsubj|END_ENTITY	These results indicate that ML-9 inhibits catecholamine secretion from adrenal chromaffin cells by inhibiting the transmembrane Ca2 + uptake mechanism , but not by inhibiting the intracellular Ca2 + - dependent mechanism .
2601564	0	catecholamine	54,67	MPTP	127,131	catecholamine	MPTP	CHEBI:33567	19255(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|administration administration|nmod|END_ENTITY	Tissue concentrations of MPTP and MPP + in relation to catecholamine depletion after the oral or subcutaneous administration of MPTP to mice .
17207896	0	catecholamine	25,38	Neuropeptide_Y	0,14	catecholamine	Neuropeptide Y	CHEBI:33567	109648(Tax:10090)	Chemical	Gene	release|amod|START_ENTITY regulates|dobj|release regulates|nsubj|END_ENTITY	Neuropeptide_Y regulates catecholamine release evoked by interleukin-1beta in mouse chromaffin cells .
10477081	0	catecholamine	57,70	PACAP	87,92	catecholamine	PACAP	CHEBI:33567	615187(Tax:9913)	Chemical	Gene	genes|amod|START_ENTITY genes|nmod|END_ENTITY	Differential involvement of PKA and PKC in regulation of catecholamine enzyme genes by PACAP .
10567198	0	catecholamine	52,65	PACAP	43,48	catecholamine	PACAP	CHEBI:33567	24166(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY END_ENTITY|nmod|secretion	Time-dependent effects of the neuropeptide PACAP on catecholamine secretion : stimulation and desensitization .
11641129	0	catecholamine	28,41	PACAP	19,24	catecholamine	PACAP	CHEBI:33567	24166(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY END_ENTITY|nmod|secretion	Role of endogenous PACAP in catecholamine secretion from the rat adrenal gland .
12235856	0	catecholamine	126,139	PACAP	33,38	catecholamine	PACAP	CHEBI:33567	615187(Tax:9913)	Chemical	Gene	-RSB-|amod|START_ENTITY coupling|nmod|-RSB- pituitary_adenylate_cyclase-activating_polypeptide|nmod|coupling END_ENTITY|dobj|pituitary_adenylate_cyclase-activating_polypeptide	-LSB- Possible role of a neuropeptide PACAP -LRB- pituitary_adenylate_cyclase-activating_polypeptide -RRB- on stimulus-secretion coupling in catecholamine neuron -RSB- .
12573802	0	catecholamine	125,138	PACAP	23,28	catecholamine	PACAP	CHEBI:33567	116	Chemical	Gene	Expression|acl|START_ENTITY Expression|nmod|mRNA mRNA|nmod|END_ENTITY	Expression of mRNA for PACAP and its receptors in intra - and extra-adrenal human pheochromocytomas and their relationship to catecholamine synthesis .
19508428	0	catecholamine	26,39	PACAP	0,5	catecholamine	PACAP	CHEBI:33567	116	Chemical	Gene	release|compound|START_ENTITY regulates|dobj|release regulates|nsubj|END_ENTITY	PACAP regulates immediate catecholamine release from adrenal chromaffin cells in an activity-dependent manner through a protein kinase C-dependent pathway .
23221599	0	catecholamine	31,44	PACAP	0,5	catecholamine	PACAP	D002395	11516(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|controls controls|compound|END_ENTITY	PACAP controls adrenomedullary catecholamine secretion and expression of catecholamine biosynthetic enzymes at high splanchnic_nerve_firing rates characteristic of stress transduction in male mice .
23221599	0	catecholamine	73,86	PACAP	0,5	catecholamine	PACAP	D002395	11516(Tax:10090)	Chemical	Gene	enzymes|amod|START_ENTITY secretion|nmod|enzymes catecholamine|dobj|secretion catecholamine|nsubj|controls controls|compound|END_ENTITY	PACAP controls adrenomedullary catecholamine secretion and expression of catecholamine biosynthetic enzymes at high splanchnic_nerve_firing rates characteristic of stress transduction in male mice .
7491942	0	catecholamine	17,30	PACAP	0,5	catecholamine	PACAP	CHEBI:33567	24166(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	PACAP stimulates catecholamine release from adrenal medulla : a novel noncholinergic secretagogue .
7553079	0	catecholamine	131,144	PACAP	112,117	catecholamine	PACAP	CHEBI:33567	615187(Tax:9913)	Chemical	Gene	secretion|amod|START_ENTITY mediates|nmod|secretion mediates|dobj|action action|nmod|polypeptide polypeptide|appos|END_ENTITY	Enhanced cAMP production mediates the stimulatory action of pituitary adenylate cyclase activating polypeptide -LRB- PACAP -RRB- on in vitro catecholamine secretion from bovine adrenal chromaffin cells .
9407393	0	catecholamine	83,96	PACAP	52,57	catecholamine	PACAP	CHEBI:33567	615187(Tax:9913)	Chemical	Gene	genes|amod|START_ENTITY expression|nmod|genes regulates|dobj|expression regulates|nsubj|Pituitary_adenylate_cyclase_activating_polypeptide Pituitary_adenylate_cyclase_activating_polypeptide|appos|END_ENTITY	Pituitary_adenylate_cyclase_activating_polypeptide -LRB- PACAP -RRB- regulates expression of catecholamine biosynthetic enzyme genes in bovine adrenal chromaffin cells .
6865904	0	catecholamine	34,47	Phospholipase_A2	0,16	catecholamine	Phospholipase A2	CHEBI:33567	104974671	Chemical	Gene	secretion|amod|START_ENTITY block|dobj|secretion block|nsubj|inhibitors inhibitors|amod|END_ENTITY	Phospholipase_A2 inhibitors block catecholamine secretion and calcium uptake in cultured bovine adrenal medullary cells .
8771559	0	catecholamine	82,95	Pituitary_adenylate_cyclase-activating_polypeptide	0,50	catecholamine	Pituitary adenylate cyclase-activating polypeptide	CHEBI:33567	116	Chemical	Gene	hydroxylase|amod|START_ENTITY expression|nmod|hydroxylase induces|dobj|expression induces|nsubj|END_ENTITY	Pituitary_adenylate_cyclase-activating_polypeptide induces gene expression of the catecholamine synthesizing enzymes , tyrosine_hydroxylase and dopamine beta hydroxylase , through 3 ' ,5 ' - cyclic_adenosine_monophosphate - and protein kinase C-dependent mechanisms in cultured porcine adrenal medullary chromaffin cells .
24603879	0	catecholamine	61,74	Pituitary_adenylate_cyclase_activating_polypeptide	0,50	catecholamine	Pituitary adenylate cyclase activating polypeptide	CHEBI:33567	24166(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|modulates modulates|amod|END_ENTITY	Pituitary_adenylate_cyclase_activating_polypeptide modulates catecholamine storage and exocytosis in PC12 cells .
7681672	0	catecholamine	21,34	Substance_P	0,11	catecholamine	Substance P	CHEBI:33567	281512(Tax:9913)	Chemical	Gene	biosynthesis|amod|START_ENTITY inhibits|dobj|biosynthesis inhibits|nsubj|END_ENTITY	Substance_P inhibits catecholamine biosynthesis stimulated by carbamylcholine in cultured adrenal chromaffin cells .
17957479	0	catecholamine	33,46	Synapsin_II	0,11	catecholamine	Synapsin II	D002395	20965(Tax:10090)	Chemical	Gene	release|amod|START_ENTITY regulates|dobj|release regulates|nsubj|END_ENTITY	Synapsin_II negatively regulates catecholamine release .
3926514	0	catecholamine	80,93	TRH	11,14	catecholamine	TRH	CHEBI:33567	25569(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of TRH and a rat TSH preparation on discrete hypothalamic and forebrain catecholamine nerve terminal networks in the hypophysectomized male rat .
508416	0	catecholamine	12,25	UDPG	39,43	catecholamine	UDPG	CHEBI:33567	7360	Chemical	Gene	treatment|amod|START_ENTITY Effects|nmod|treatment Effects|nmod|levels levels|compound|END_ENTITY	-LSB- Effects of catecholamine treatment on UDPG levels in white and red skeletal muscle -RSB- .
1688031	0	catecholamine	96,109	VIP	12,15	catecholamine	VIP	CHEBI:33567	117064(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY role|nmod|secretion neurotransmitter|parataxis|role neurotransmitter|nsubj|END_ENTITY	The peptide VIP is a neurotransmitter in rat adrenal medulla : physiological role in controlling catecholamine secretion .
3534807	0	catecholamine	56,69	VIP	14,17	catecholamine	VIP	CHEBI:33567	7432	Chemical	Gene	secretion|amod|START_ENTITY distribution|nmod|secretion END_ENTITY|dep|distribution	Fetal adrenal VIP : distribution and effect on medullary catecholamine secretion .
8238445	0	catecholamine	29,42	VIP	113,116	catecholamine	VIP	CHEBI:33567	484038(Tax:9615)	Chemical	Gene	release|compound|START_ENTITY evidence|nmod|release mediated|nsubj|evidence mediated|nmod|mechanism mechanism|dep|effect effect|nmod|END_ENTITY	In vivo evidence for adrenal catecholamine release mediated by nonnicotinic mechanism : local medullary effect of VIP .
9176354	0	catecholamine	15,28	VIP	41,44	catecholamine	VIP	CHEBI:33567	484038(Tax:9615)	Chemical	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	Canine adrenal catecholamine response to VIP is blocked by PACAP - -LRB- 6-27 -RRB- in vivo .
10593661	0	catecholamine	72,85	angiotensin-converting_enzyme	25,54	catecholamine	angiotensin-converting enzyme	CHEBI:33567	610668(Tax:9615)	Chemical	Gene	secretion|compound|START_ENTITY role|nmod|secretion role|nmod|END_ENTITY	Functional role of local angiotensin-converting_enzyme -LRB- ACE -RRB- in adrenal catecholamine secretion in vivo .
2170177	0	catecholamine	37,50	angiotensin_II	15,29	catecholamine	angiotensin II	CHEBI:33567	24179(Tax:10116)	Chemical	Gene	content|amod|START_ENTITY END_ENTITY|nmod|content	-LSB- The effect of angiotensin_II on the catecholamine content of the blood plasma in rats -RSB- .
2322238	0	catecholamine	35,48	angiotensin_II	17,31	catecholamine	angiotensin II	CHEBI:33567	24179(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY END_ENTITY|nmod|synthesis	The influence of angiotensin_II on catecholamine synthesis in neuronal_cultures from rat brain .
6130707	0	catecholamine	43,56	angiotensin_II	21,35	catecholamine	angiotensin II	CHEBI:33567	24179(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY alters|dobj|activity alters|nsubj|injection injection|nmod|END_ENTITY	Central injection of angiotensin_II alters catecholamine activity in rat brain .
3138577	0	catecholamine	37,50	arginine_vasopressin	79,99	catecholamine	arginine vasopressin	CHEBI:33567	551	Chemical	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	Differential effects of hypothalamic catecholamine depletion on the release of arginine_vasopressin and CRF-41 into hypothalamo-hypophyseal portal blood .
15942127	0	catecholamine	74,87	bradykinin	26,36	catecholamine	bradykinin	CHEBI:33567	478666(Tax:9615)	Chemical	Gene	release|compound|START_ENTITY release|amod|END_ENTITY	Nitric_oxide inhibits the bradykinin B2 receptor-mediated adrenomedullary catecholamine release but has no effect on adrenal blood flow response in vivo .
10888068	0	catecholamine	36,49	c-fos	16,21	catecholamine	c-fos	CHEBI:33567	314322(Tax:10116)	Chemical	Gene	neurons|amod|START_ENTITY expression|nmod|neurons expression|amod|END_ENTITY	Ethanol-induced c-fos expression in catecholamine - and neuropeptide_Y-producing neurons in rat brainstem .
8190253	0	catecholamine	62,75	c-fos	0,5	catecholamine	c-fos	CHEBI:33567	2353	Chemical	Gene	START_ENTITY|nsubj|expression expression|amod|END_ENTITY	c-fos expression in hypothalamic neurosecretory and brainstem catecholamine cells following noxious somatic stimuli .
16824046	0	catecholamine	41,54	calbindin-D28K	13,27	catecholamine	calbindin-D28K	CHEBI:33567	12307(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	Dual role of calbindin-D28K in vesicular catecholamine release from mouse chromaffin cells .
16542735	0	catecholamine	104,117	catechol-O-methyltransferase	17,45	catecholamine	catechol-O-methyltransferase	CHEBI:33567	1312	Chemical	Gene	metabolites|amod|START_ENTITY concentration|nmod|metabolites polymorphism|nmod|concentration polymorphism|amod|END_ENTITY	Influence of the catechol-O-methyltransferase Val108/158Met polymorphism on the plasma concentration of catecholamine metabolites and on clinical features in type_I bipolar_disorder -- a preliminary report .
2225697	0	catecholamine	26,39	catechol-O-methyltransferase	57,85	catecholamine	catechol-O-methyltransferase	CHEBI:33567	1312	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|amod|END_ENTITY	Exercise hemodynamics and catecholamine metabolism after catechol-O-methyltransferase inhibition with nitecapone .
9326274	0	catecholamine	93,106	catechol-O-methyltransferase	32,60	catecholamine	catechol-O-methyltransferase	CHEBI:33567	1312	Chemical	Gene	transporters|compound|START_ENTITY expressing|dobj|transporters Metabolism|acl|expressing Metabolism|nmod|catecholamines catecholamines|nmod|END_ENTITY	Metabolism of catecholamines by catechol-O-methyltransferase in cells expressing recombinant catecholamine transporters .
9774242	0	catecholamine	33,46	catechol-O-methyltransferase	66,94	catecholamine	catechol-O-methyltransferase	CHEBI:33567	24267(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY levels|nmod|inhibition inhibition|amod|END_ENTITY	No change of brain extracellular catecholamine levels after acute catechol-O-methyltransferase inhibition : a microdialysis study in anaesthetized rats .
3497586	0	catecholamine	66,79	corticotropin-releasing_factor	14,44	catecholamine	corticotropin-releasing factor	CHEBI:33567	486977(Tax:9615)	Chemical	Gene	secretion|amod|START_ENTITY Comparison|nmod|secretion Comparison|nmod|END_ENTITY	Comparison of corticotropin-releasing_factor and acetylcholine on catecholamine secretion in dogs .
6319453	0	catecholamine	54,67	corticotropin-releasing_factor	20,50	catecholamine	corticotropin-releasing factor	CHEBI:33567	1392	Chemical	Gene	vasopressin|compound|START_ENTITY effect|nmod|vasopressin effect|nmod|END_ENTITY	The effect of ovine corticotropin-releasing_factor on catecholamine , vasopressin , and aldosterone secretion in normal man .
16163519	0	catecholamine	75,88	dopamine_beta-hydroxylase	11,36	catecholamine	dopamine beta-hydroxylase	CHEBI:33567	13166(Tax:10090)	Chemical	Gene	genotype|nmod|START_ENTITY genotype|amod|END_ENTITY	Effects of dopamine_beta-hydroxylase genotype and disulfiram inhibition on catecholamine homeostasis in mice .
2473320	0	catecholamine	48,61	endothelin-1	20,32	catecholamine	endothelin-1	CHEBI:33567	281137(Tax:9913)	Chemical	Gene	stimulation|nmod|START_ENTITY stimulation|amod|END_ENTITY	Characterization of endothelin-1 stimulation of catecholamine release from adrenal chromaffin cells .
6823202	0	catecholamine	7,20	gastrin	31,38	catecholamine	gastrin	CHEBI:33567	2520	Chemical	Gene	START_ENTITY|dobj|concentrations concentrations|compound|END_ENTITY	Plasma catecholamine and serum gastrin concentrations during sham feeding .
2243613	0	catecholamine	65,78	insulin	34,41	catecholamine	insulin	CHEBI:33567	3630	Chemical	Gene	content|amod|START_ENTITY influence|nmod|content influence|nmod|action action|nmod|END_ENTITY	Neural influence on the action of insulin in the adrenomedullary catecholamine content in the pigeon .
2560726	0	catecholamine	48,61	insulin	70,77	catecholamine	insulin	CHEBI:33567	3630	Chemical	Gene	resistance|amod|START_ENTITY resistance|compound|END_ENTITY	Beta-adrenoceptors desensitization may modulate catecholamine induced insulin resistance in human pheochromocytoma .
2648843	0	catecholamine	38,51	insulin	11,18	catecholamine	insulin	CHEBI:33567	105613195	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|infusion infusion|compound|END_ENTITY	Effects of insulin infusion on plasma catecholamine concentration in fetal sheep .
5036567	0	catecholamine	14,27	insulin	42,49	catecholamine	insulin	CHEBI:33567	3630	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Antagonism of catecholamine inhibition of insulin secretion by methysergide .
717534	0	catecholamine	35,48	insulin	11,18	catecholamine	insulin	CHEBI:33567	100009181(Tax:9986)	Chemical	Gene	cardiomyopathy|compound|START_ENTITY Effects|nmod|cardiomyopathy Effects|nmod|END_ENTITY	Effects of insulin on experimental catecholamine cardiomyopathy .
10480609	0	catecholamine	95,108	leptin	26,32	catecholamine	leptin	CHEBI:33567	25608(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY increase|nmod|secretion activation|dep|increase activation|nmod|END_ENTITY	Sympathetic activation of leptin via the ventromedial hypothalamus : leptin-induced increase in catecholamine secretion .
12438173	0	catecholamine	14,27	leptin	41,47	catecholamine	leptin	CHEBI:33567	280836(Tax:9913)	Chemical	Gene	synthesis|amod|START_ENTITY Regulation|nmod|synthesis Regulation|nmod|END_ENTITY	Regulation of catecholamine synthesis by leptin .
8922360	0	catecholamine	46,59	leptin	26,32	catecholamine	leptin	CHEBI:33567	3952	Chemical	Gene	adipocytes|amod|START_ENTITY expression|nmod|adipocytes expression|nmod|gene gene|compound|END_ENTITY	Reduced expression of the leptin gene -LRB- ob -RRB- by catecholamine through a G -LRB- S -RRB- protein-coupled pathway in 3T3-L1 adipocytes .
9619531	0	catecholamine	36,49	leptin	75,81	catecholamine	leptin	CHEBI:33567	3952	Chemical	Gene	synthesis|compound|START_ENTITY inhibition|nmod|synthesis alter|nsubj|inhibition alter|dobj|secretion secretion|compound|END_ENTITY	Prolonged inhibition of presynaptic catecholamine synthesis does not alter leptin secretion in normal-weight men and women .
1206325	0	catecholamine	108,121	monoamine_oxidase	25,42	catecholamine	monoamine oxidase	CHEBI:33567	29253(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY Effects|nmod|levels Effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Effects of injections of monoamine_oxidase inhibitor or saline into the uterus in late pregnancy on uterine catecholamine levels related to abnormal parturition in rats .
6383859	0	catecholamine	47,60	nerve_growth_factor	14,33	catecholamine	nerve growth factor	CHEBI:33567	4803	Chemical	Gene	contents|amod|START_ENTITY effect|nmod|contents effect|nmod|END_ENTITY	The effect of nerve_growth_factor -LRB- NGF -RRB- on the catecholamine contents of two human pheochromocytomas in tissue culture .
8752116	0	catecholamine	13,26	neuropeptide_Y	51,65	catecholamine	neuropeptide Y	CHEBI:33567	24604(Tax:10116)	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Mechanism of catecholamine synthesis inhibition by neuropeptide_Y : role of Ca2 + channels and protein kinases .
20488102	0	catecholamine	23,36	neurotensin	11,22	catecholamine	neurotensin	CHEBI:33567	299757(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Studies Studies|nmod|END_ENTITY	Studies on neurotensin catecholamine interactions in the hypothalamus and in the forebrain of the male rat .
7178654	0	catecholamine	74,87	phenylethanolamine_N-methyltransferase	11,49	catecholamine	phenylethanolamine N-methyltransferase	CHEBI:33567	24661(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|inhibitors inhibitors|amod|END_ENTITY	Effects of phenylethanolamine_N-methyltransferase inhibitors on rat brain catecholamine levels and body temperature .
6417385	0	catecholamine	14,27	phospholipase_A2	69,85	catecholamine	phospholipase A2	CHEBI:33567	151056	Chemical	Gene	Prevention|nmod|START_ENTITY release|nsubj|Prevention release|nmod|END_ENTITY	Prevention of catecholamine release from adrenal chromaffin cells by phospholipase_A2 - and lipoxygenase-inhibitors .
7206380	0	catecholamine	38,51	phospholipase_A2	14,30	catecholamine	phospholipase A2	CHEBI:33567	151056	Chemical	Gene	release|amod|START_ENTITY END_ENTITY|nmod|release	Activation by phospholipase_A2 of the catecholamine release from isolated chromaffin granules .
12235856	0	catecholamine	126,139	pituitary_adenylate_cyclase-activating_polypeptide	40,90	catecholamine	pituitary adenylate cyclase-activating polypeptide	CHEBI:33567	615187(Tax:9913)	Chemical	Gene	-RSB-|amod|START_ENTITY coupling|nmod|-RSB- END_ENTITY|nmod|coupling	-LSB- Possible role of a neuropeptide PACAP -LRB- pituitary_adenylate_cyclase-activating_polypeptide -RRB- on stimulus-secretion coupling in catecholamine neuron -RSB- .
8384995	0	catecholamine	93,106	pituitary_adenylate_cyclase-activating_polypeptide	39,89	catecholamine	pituitary adenylate cyclase-activating polypeptide	CHEBI:33567	116	Chemical	Gene	secretion|amod|START_ENTITY END_ENTITY|nmod|secretion	Ca -LRB- 2 + -RRB- - dependent stimulatory effect of pituitary_adenylate_cyclase-activating_polypeptide on catecholamine secretion from cultured porcine adrenal medullary chromaffin cells .
8631854	0	catecholamine	119,132	pituitary_adenylate_cyclase-activating_polypeptide	31,81	catecholamine	pituitary adenylate cyclase-activating polypeptide	CHEBI:33567	24166(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY evoke|dobj|secretion utilizes|xcomp|evoke utilizes|nsubj|transmitter transmitter|appos|END_ENTITY	A non-cholinergic transmitter , pituitary_adenylate_cyclase-activating_polypeptide , utilizes a novel mechanism to evoke catecholamine secretion in rat adrenal chromaffin cells .
9100459	0	catecholamine	27,40	pituitary_adenylate_cyclase-activating_polypeptide	110,160	catecholamine	pituitary adenylate cyclase-activating polypeptide	CHEBI:33567	615187(Tax:9913)	Chemical	Gene	secretion|amod|START_ENTITY secretion|nmod|cells cells|nmod|culture culture|acl|induced induced|nmod|END_ENTITY	Potentiation by ouabain of catecholamine secretion from bovine adrenal chromaffin cells in culture induced by pituitary_adenylate_cyclase-activating_polypeptide : evidence for involvements of Na + and Ca2 + movements .
3243966	0	catecholamine	39,52	prolactin	26,35	catecholamine	prolactin	CHEBI:33567	24683(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY effect|nmod|synthesis effect|nmod|END_ENTITY	Possible direct effect of prolactin on catecholamine synthesis and release in rat adrenal medulla : in vitro studies .
11748228	0	catecholamine	25,38	rab3	49,53	catecholamine	rab3	CHEBI:33567	25531(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY uptake|nsubj|regulation uptake|nmod|END_ENTITY	Coordinate regulation of catecholamine uptake by rab3 and phosphoinositide_3-kinase .
6758873	0	catecholamine	21,34	renin	46,51	catecholamine	renin	CHEBI:33567	5972	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	-LSB- Reproductibility of catecholamine and plasma renin activity values during exercise testing in normal subjects -RSB- .
6128682	0	catecholamine	35,48	somatostatin	60,72	catecholamine	somatostatin	CHEBI:33567	403993(Tax:9615)	Chemical	Gene	release|compound|START_ENTITY release|nmod|END_ENTITY	Facilitation of stimulation-evoked catecholamine release by somatostatin in dog perfused adrenal glands .
3923755	0	catecholamine	52,65	thyrotrophin-releasing_hormone	11,41	catecholamine	thyrotrophin-releasing hormone	CHEBI:33567	7200	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of thyrotrophin-releasing_hormone on plasma catecholamine levels in acromegalics .
9013196	0	catecholamine	106,119	thyrotropin-releasing_hormone	11,40	catecholamine	thyrotropin-releasing hormone	CHEBI:33567	25569(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of thyrotropin-releasing_hormone and its analogue , NS-3 , on blood pressure , heart rate , and serum catecholamine levels in rats .
3107575	0	catecholamine	52,65	vasoactive_intestinal_polypeptide	15,48	catecholamine	vasoactive intestinal polypeptide	CHEBI:33567	280956(Tax:9913)	Chemical	Gene	synthesis|amod|START_ENTITY Stimulation|nmod|synthesis Stimulation|nmod|END_ENTITY	Stimulation by vasoactive_intestinal_polypeptide of catecholamine synthesis in isolated bovine adrenal chromaffin cells .
2822768	0	catecholamines	11,25	ACTH	72,76	catecholamines	ACTH	MESH:D002395	5443	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of catecholamines on secretion of adrenocorticotrophic hormone -LRB- ACTH -RRB- in man .
8025914	0	catecholamines	68,82	Angiotensin_II	0,14	catecholamines	Angiotensin II	MESH:D002395	24179(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Angiotensin_II associated cardiac_myocyte_necrosis : role of adrenal catecholamines .
3345844	0	catecholamines	63,77	Calmodulin	0,10	catecholamines	Calmodulin	MESH:D002395	24242(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|release release|amod|END_ENTITY	Calmodulin - and protein phosphorylation-independent release of catecholamines from PC-12 cells .
10471719	0	catecholamines	4,18	Catsup	23,29	catecholamines	Catsup	MESH:D002395	48805(Tax:7227)	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	The catecholamines up -LRB- Catsup -RRB- protein of Drosophila_melanogaster functions as a negative regulator of tyrosine hydroxylase activity .
9497875	0	catecholamines	123,137	IGF-I	41,46	catecholamines	IGF-I	MESH:D002395	3479	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|infusion infusion|nmod|END_ENTITY	The effect of an intravenous infusion of IGF-I and insulin on IGFBP-1 , IGFBP-3 , acid labile subunit , free and bound IGF-I , catecholamines and potassium in normal volunteers during an amino_acid and glucose clamp .
15456539	0	catecholamines	10,24	IL-2	28,32	catecholamines	IL-2	MESH:D002395	116562(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|production production|compound|END_ENTITY	Effect of catecholamines on IL-2 production and NK cytotoxicity of rats in vitro .
15935613	0	catecholamines	125,139	IL-2	84,88	catecholamines	IL-2	MESH:D002395	16183(Tax:10090)	Chemical	Gene	required|nsubjpass|START_ENTITY necessary|advcl|required necessary|nmod|END_ENTITY	Glucocorticoids produced during exercise may be necessary for optimal virus-induced IL-2 and cell proliferation whereas both catecholamines and glucocorticoids may be required for adequate immune defense to viral_infection .
11549649	0	catecholamines	99,113	Insulin	0,7	catecholamines	Insulin	MESH:D002395	3630	Chemical	Gene	mediated|nmod|START_ENTITY mediated|nsubj|END_ENTITY	Insulin mediated inhibition of hormone sensitive lipase activity in vivo in relation to endogenous catecholamines in healthy subjects .
2615917	0	catecholamines	30,44	MPTP	91,95	catecholamines	MPTP	MESH:D002395	19255(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|dose dose|nmod|END_ENTITY	The acute effect on levels of catecholamines and metabolites in brain , of a single dose of MPTP in 8 strains of mice .
3346832	0	catecholamines	57,71	Neuropeptide_Y	0,14	catecholamines	Neuropeptide Y	MESH:D002395	504216(Tax:9913)	Chemical	Gene	release|nmod|START_ENTITY inhibits|dobj|release inhibits|nsubj|END_ENTITY	Neuropeptide_Y inhibits the nicotine-mediated release of catecholamines from bovine adrenal chromaffin cells .
8190350	0	catecholamines	144,158	Neuropeptide_Y	0,14	catecholamines	Neuropeptide Y	MESH:D002395	24604(Tax:10116)	Chemical	Gene	mediated|nmod|START_ENTITY zone|acl:relcl|mediated induced|nmod|zone peptide|acl|induced peptide|amod|END_ENTITY	Neuropeptide_Y -LRB- NPY -RRB- - and vasoactive intestinal peptide -LRB- VIP -RRB- - induced aldosterone secretion by rat capsule/glomerular zone could be mediated by catecholamines via beta 1 adrenergic receptors .
96135	0	catecholamines	33,47	Parathyroid_hormone	0,19	catecholamines	Parathyroid hormone	MESH:D002395	280903(Tax:9913)	Chemical	Gene	responses|nmod|START_ENTITY responses|amod|END_ENTITY	Parathyroid_hormone responses to catecholamines and to changes of extracellular calcium in cows .
24374096	0	catecholamines	86,100	REDD1	19,24	catecholamines	REDD1	MESH:D002395	74747(Tax:10090)	Chemical	Gene	induction|nmod|START_ENTITY induction|nmod|expression expression|compound|END_ENTITY	Rapid induction of REDD1 gene expression in macrophages in response to stress-related catecholamines .
5895192	0	catecholamines	73,87	Tyrosine_hydroxylase	1,21	catecholamines	Tyrosine hydroxylase	MESH:D002395	7054	Chemical	Gene	biosynthesis|nmod|START_ENTITY involved|nmod|biosynthesis enzyme|acl|involved END_ENTITY|appos|enzyme	-LSB- Tyrosine_hydroxylase , a specific enzyme involved in the biosynthesis of catecholamines in the brain and sympathetically innervated tissues -RSB- .
3656194	0	catecholamines	62,76	Vasoactive_intestinal_polypeptide	0,33	catecholamines	Vasoactive intestinal polypeptide	MESH:D002395	117064(Tax:10116)	Chemical	Gene	secretion|nmod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Vasoactive_intestinal_polypeptide stimulates the secretion of catecholamines from the rat adrenal gland .
3304733	0	catecholamines	62,76	Vasopressin	0,11	catecholamines	Vasopressin	MESH:D002395	551	Chemical	Gene	relationship|nmod|START_ENTITY END_ENTITY|dep|relationship	Vasopressin in end-stage_renal_disease : relationship to salt , catecholamines and renin activity .
20147605	0	catecholamines	10,24	angiotensin_II	100,114	catecholamines	angiotensin II	MESH:D002395	24179(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|interaction interaction|nmod|END_ENTITY	Effect of catecholamines on rat medullary thick ascending limb chloride transport : interaction with angiotensin_II .
7735274	0	catecholamines	44,58	angiotensin_II	16,30	catecholamines	angiotensin II	MESH:D002395	183	Chemical	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of angiotensin_II with central catecholamines .
2143167	0	catecholamines	56,70	atrial_natriuretic_peptide	19,45	catecholamines	atrial natriuretic peptide	MESH:D002395	608289(Tax:9615)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Central effects of atrial_natriuretic_peptide on plasma catecholamines , vasopressin , renin and beta-endorphin and on renal excretory functions in the dog .
9176257	0	catecholamines	19,33	beta_2-adrenoreceptor	41,62	catecholamines	beta 2-adrenoreceptor	MESH:D002395	154	Chemical	Gene	START_ENTITY|nmod|system system|amod|END_ENTITY	Chronic effects of catecholamines on the beta_2-adrenoreceptor system in cultured human airway epithelial cells .
22471594	0	catecholamines	45,59	brain_natriuretic_peptide	63,88	catecholamines	brain natriuretic peptide	MESH:D002395	4879	Chemical	Gene	START_ENTITY|nmod|release release|amod|END_ENTITY	Effect of lipopolysaccharide , cytokines , and catecholamines on brain_natriuretic_peptide release from human myocardium .
1791995	0	catecholamines	36,50	c-Fos	0,5	catecholamines	c-Fos	MESH:D002395	2353	Chemical	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	c-Fos response to administration of catecholamines into brain by microdialysis .
9138721	0	catecholamines	19,33	c-fos	69,74	catecholamines	c-fos	MESH:D002395	314322(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Modulatory role of catecholamines in the transsynaptic expression of c-fos in the rat medial prefrontal cortex induced by disinhibition of the mediodorsal thalamus : a study employing microdialysis and immunohistochemistry .
2783568	0	catecholamines	93,107	corticotropin-releasing_factor	13,43	catecholamines	corticotropin-releasing factor	MESH:D002395	81648(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY Secretion|dep|effects Secretion|nmod|END_ENTITY	Secretion of corticotropin-releasing_factor from cultured rat hypothalamic cells : effects of catecholamines .
160824	0	catecholamines	60,74	dopamine-beta-hydroxylase	91,116	catecholamines	dopamine-beta-hydroxylase	MESH:D002395	1621	Chemical	Gene	measurement|nmod|START_ENTITY measurement|nmod|END_ENTITY	-LSB- Determination of the adrenergic response by measurement of catecholamines and activity of dopamine-beta-hydroxylase -LRB- D-beta-B -RRB- in arterial capillary blood -RSB- .
12389021	0	catecholamines	63,77	endothelin-1	22,34	catecholamines	endothelin-1	MESH:D002395	1906	Chemical	Gene	START_ENTITY|nsubj|variation variation|nmod|END_ENTITY	Seasonal variation of endothelin-1 , angiotensin_II , and plasma catecholamines and their relation to outside temperature .
1395110	0	catecholamines	46,60	endothelin-1	15,27	catecholamines	endothelin-1	MESH:D002395	403424(Tax:9615)	Chemical	Gene	release|nmod|START_ENTITY END_ENTITY|nmod|release	Enhancement by endothelin-1 of the release of catecholamines from the canine adrenal gland in response to splanchnic nerve stimulation .
15838288	0	catecholamines	28,42	endothelin-1	65,77	catecholamines	endothelin-1	MESH:D002395	403424(Tax:9615)	Chemical	Gene	responses|nmod|START_ENTITY responses|nmod|END_ENTITY	Cardiovascular responses to catecholamines and interactions with endothelin-1 and adenine_nucleosides in the pericardium of the dog heart .
4111580	0	catecholamines	34,48	gastrin	15,22	catecholamines	gastrin	MESH:D002395	2520	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|Stimulation Stimulation|nmod|END_ENTITY	Stimulation of gastrin release by catecholamines .
634141	0	catecholamines	10,24	gastrin	28,35	catecholamines	gastrin	MESH:D002395	25320(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|release release|compound|END_ENTITY	Effect of catecholamines on gastrin release .
7014320	0	catecholamines	12,26	gastrin	45,52	catecholamines	gastrin	MESH:D002395	2520	Chemical	Gene	START_ENTITY|nmod|control control|nmod|END_ENTITY	The role of catecholamines in the control of gastrin and acid secretion during insulin hypoglycaemia in man .
12148128	5	catecholamines	693,707	hypotension	746,757	catecholamines	vasopressin	MESH:D002395	551	Chemical	Gene	START_ENTITY|nmod|treatment treatment|nmod|END_ENTITY	Previous case reports documented vasopressin as an effective alternative to catecholamines in the treatment of milrinone-induced hypotension .
16424707	0	catecholamines	91,105	inducible_nitric_oxide_synthase	8,39	catecholamines	inducible nitric oxide synthase	MESH:D002395	18126(Tax:10090)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of inducible_nitric_oxide_synthase in the reduced responsiveness of the myocardium to catecholamines in a hyperdynamic , murine model of septic_shock .
2276081	0	catecholamines	73,87	insulin	95,102	catecholamines	insulin	MESH:D002395	483665(Tax:9615)	Chemical	Gene	START_ENTITY|nmod|hypoglycemia hypoglycemia|compound|END_ENTITY	Effect of functional adrenalectomy on glucagon secretion and circulating catecholamines during insulin hypoglycemia in the dog .
6126124	0	catecholamines	64,78	insulin	23,30	catecholamines	insulin	MESH:D002395	3630	Chemical	Gene	role|nmod|START_ENTITY Glucoregulation|dep|role Glucoregulation|nmod|END_ENTITY	Glucoregulation during insulin and glucagon_deficiency : role of catecholamines .
6339003	0	catecholamines	29,43	insulin	10,17	catecholamines	insulin	MESH:D002395	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of insulin on central catecholamines .
6351521	0	catecholamines	12,26	insulin	75,82	catecholamines	insulin	MESH:D002395	3630	Chemical	Gene	role|nmod|START_ENTITY role|nmod|hypoglycaemia hypoglycaemia|compound|END_ENTITY	The role of catecholamines in the control of gastric_acid secretion during insulin hypoglycaemia and modified sham feeding .
15710461	0	catecholamines	40,54	interleukin-1_beta	58,76	catecholamines	interleukin-1 beta	MESH:D002395	16176(Tax:10090)	Chemical	Gene	actions|nmod|START_ENTITY actions|nmod|END_ENTITY	Autocrine actions of macrophage-derived catecholamines on interleukin-1_beta .
8843757	0	catecholamines	96,110	interleukin-6	20,33	catecholamines	interleukin-6	MESH:D002395	3569	Chemical	Gene	secretion|nmod|START_ENTITY secretion|amod|END_ENTITY	Exercise stimulates interleukin-6 secretion : inhibition by glucocorticoids and correlation with catecholamines .
10337850	0	catecholamines	60,74	leptin	8,14	catecholamines	leptin	MESH:D002395	3952	Chemical	Gene	hypersecretion|nmod|START_ENTITY suppression|nmod|hypersecretion suppression|nsubj|Lack Lack|nmod|END_ENTITY	Lack of leptin suppression in response to hypersecretion of catecholamines in pheochromocytoma patients .
12371054	0	catecholamines	3,17	leptin	48,54	catecholamines	leptin	MESH:D002395	3952	Chemical	Gene	influence|nsubj|START_ENTITY influence|dobj|level level|nmod|END_ENTITY	Do catecholamines influence the level of plasma leptin in patients with phaeochromocytoma ?
15964536	0	catecholamines	61,75	leptin	36,42	catecholamines	leptin	MESH:D002395	3952	Chemical	Gene	concentration|nmod|START_ENTITY concentration|compound|END_ENTITY	Cigarette smoking may reduce plasma leptin concentration via catecholamines .
9831308	0	catecholamines	47,61	leptin	27,33	catecholamines	leptin	MESH:D002395	3952	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Evidence Evidence|nmod|inhibition inhibition|nmod|END_ENTITY	Evidence for inhibition of leptin secretion by catecholamines in man .
9920865	0	catecholamines	74,88	macrophage_migration_inhibitory_factor	19,57	catecholamines	macrophage migration inhibitory factor	MESH:D002395	4282	Chemical	Gene	activity|nmod|START_ENTITY activity|nmod|END_ENTITY	Enzyme activity of macrophage_migration_inhibitory_factor toward oxidized catecholamines .
6641229	0	catecholamines	12,26	myoglobin	30,39	catecholamines	myoglobin	MESH:D002395	608715(Tax:9615)	Chemical	Gene	START_ENTITY|nmod|content content|compound|END_ENTITY	The role of catecholamines in myoglobin content increase in the myocardium .
12668588	0	catecholamines	24,38	neuropeptide_Y	42,56	catecholamines	neuropeptide Y	MESH:D002395	24604(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|rats rats|amod|transgenic transgenic|advmod|END_ENTITY	Hypotension and reduced catecholamines in neuropeptide_Y transgenic rats .
2431356	0	catecholamines	41,55	neuropeptide_Y	14,28	catecholamines	neuropeptide Y	MESH:D002395	24604(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of neuropeptide_Y on striatal catecholamines .
3589002	0	catecholamines	148,162	neuropeptide_Y	60,74	catecholamines	neuropeptide Y	MESH:D002395	24604(Tax:10116)	Chemical	Gene	relationship|nmod|START_ENTITY studies|dep|relationship studies|nmod|effects effects|nmod|administration administration|nmod|END_ENTITY	Further studies on the effects of central administration of neuropeptide_Y on neuroendocrine function in the male rat : relationship to hypothalamic catecholamines .
3840322	0	catecholamines	80,94	neuropeptide_Y	44,58	catecholamines	neuropeptide Y	MESH:D002395	4852	Chemical	Gene	relation|nmod|START_ENTITY storage|nmod|relation storage|nmod|END_ENTITY	Subcellular storage and axonal transport of neuropeptide_Y -LRB- NPY -RRB- in relation to catecholamines in the cat .
6144080	0	catecholamines	77,91	neuropeptide_Y	29,43	catecholamines	neuropeptide Y	MESH:D002395	24604(Tax:10116)	Chemical	Gene	immunoreactivity|nmod|START_ENTITY co-existence|dep|immunoreactivity co-existence|nmod|END_ENTITY	Differential co-existence of neuropeptide_Y -LRB- NPY -RRB- - like immunoreactivity with catecholamines in the central nervous system of the rat .
11502876	0	catecholamines	40,54	norepinephrine_transporter	72,98	catecholamines	norepinephrine transporter	MESH:D002395	6530	Chemical	Gene	START_ENTITY|acl|identified identified|nmod|END_ENTITY	A Na -LRB- + -RRB- / Cl -LRB- - -RRB- - dependent transporter for catecholamines , identified as a norepinephrine_transporter , is expressed in the brain of the teleost fish medaka -LRB- Oryzias_latipes -RRB- .
12137927	0	catecholamines	54,68	norepinephrine_transporter	14,40	catecholamines	norepinephrine transporter	MESH:D002395	20538(Tax:10090)	Chemical	Gene	abundance|nmod|START_ENTITY abundance|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of norepinephrine_transporter abundance by catecholamines and desipramine in vivo .
16573647	0	catecholamines	76,90	norepinephrine_transporter	34,60	catecholamines	norepinephrine transporter	MESH:D002395	6530	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Chronic depolarization stimulates norepinephrine_transporter expression via catecholamines .
633081	0	catecholamines	55,69	ornithine_decarboxylase	19,42	catecholamines	ornithine decarboxylase	MESH:D002395	24609(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Responses Responses|nmod|END_ENTITY	Responses of heart ornithine_decarboxylase and adrenal catecholamines to methadone and sympathetic stimulants in developing and adults rats .
13627	0	catecholamines	51,65	prolactin	11,20	catecholamines	prolactin	MESH:D002395	5617	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Control Control|nmod|END_ENTITY	Control of prolactin secretion by the hypothalamic catecholamines .
1183075	0	catecholamines	28,42	renin	46,51	catecholamines	renin	MESH:D002395	5972	Chemical	Gene	action|nmod|START_ENTITY action|nmod|secretion secretion|compound|END_ENTITY	Direct intrarenal action of catecholamines on renin secretion .
1192688	0	catecholamines	7,21	renin	30,35	catecholamines	renin	MESH:D002395	5972	Chemical	Gene	START_ENTITY|appos|activity activity|compound|END_ENTITY	Plasma catecholamines , plasma renin activity and plasma aldosterone in tetraplegic man , horizontal and tilted .
1312445	0	catecholamines	104,118	renin	26,31	catecholamines	renin	MESH:D002395	280909(Tax:9913)	Chemical	Gene	effect|nmod|START_ENTITY Regulation|dep|effect Regulation|nmod|system system|compound|END_ENTITY	Regulation of the adrenal renin angiotensin system in cultured bovine zona glomerulosa cells : effect of catecholamines .
238481	0	catecholamines	56,70	renin	98,103	catecholamines	renin	MESH:D002395	5972	Chemical	Gene	effect|acl:relcl|START_ENTITY plasma|nsubj|effect plasma|dobj|activity activity|compound|END_ENTITY	The effect of clonidine and penbutolol , respectively on catecholamines in blood and urine , plasma renin activity and urinary aldosterone in hypertensive patients .
3055993	0	catecholamines	49,63	renin	33,38	catecholamines	renin	MESH:D002395	5972	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|ciclosporin ciclosporin|nmod|activity activity|compound|END_ENTITY	Effects of ciclosporin on plasma renin activity , catecholamines and prostaglandins in patients with idiopathic uveitis .
426082	0	catecholamines	12,26	renin	49,54	catecholamines	renin	MESH:D002395	403838(Tax:9615)	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Circulating catecholamines and control of plasma renin activity in conscious dogs .
520398	0	catecholamines	35,49	renin	51,56	catecholamines	renin	MESH:D002395	5972	Chemical	Gene	labetalol|nmod|START_ENTITY Effect|nmod|labetalol END_ENTITY|nsubj|Effect	Effect of oral labetalol on plasma catecholamines , renin and aldosterone in patients with severe arterial hypertension .
6274596	0	catecholamines	8,22	renin	31,36	catecholamines	renin	MESH:D002395	5972	Chemical	Gene	START_ENTITY|appos|activity activity|compound|END_ENTITY	Urinary catecholamines , plasma renin activity and blood pressure in newborns : effects of narcotic withdrawal .
6354727	0	catecholamines	55,69	renin	29,34	catecholamines	renin	MESH:D002395	5972	Chemical	Gene	START_ENTITY|nsubj|changes changes|nmod|activity activity|compound|END_ENTITY	Sequential changes in plasma renin activity and plasma catecholamines in mildly hypertensive patients during acute , furosemide-induced body-fluid loss .
6378438	0	catecholamines	27,41	renin	92,97	catecholamines	renin	MESH:D002395	5972	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Supine and standing plasma catecholamines in essential hypertensive patients with different renin levels .
673021	0	catecholamines	49,63	renin	67,72	catecholamines	renin	MESH:D002395	24715(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Inhibitory effect of tyramine-induced release of catecholamines on renin secretion .
6754144	0	catecholamines	16,30	renin	32,37	catecholamines	renin	MESH:D002395	5972	Chemical	Gene	Prostaglandins|appos|START_ENTITY END_ENTITY|nsubj|Prostaglandins	Prostaglandins , catecholamines , renin and aldosterone during hypertensive and normotensive pregnancy .
7004727	0	catecholamines	7,21	renin	33,38	catecholamines	renin	MESH:D002395	5972	Chemical	Gene	START_ENTITY|dobj|activity activity|compound|END_ENTITY	Plasma catecholamines and plasma renin activity at birth and during the first days of life .
7015796	0	catecholamines	31,45	renin	47,52	catecholamines	renin	MESH:D002395	5972	Chemical	Gene	activity|compound|START_ENTITY activity|dep|END_ENTITY	Prolonged clonidine treatment : catecholamines , renin activity and aldosterone following exercise in hypertensives .
7879962	0	catecholamines	7,21	renin	140,145	catecholamines	renin	MESH:D002395	5972	Chemical	Gene	START_ENTITY|nmod|concentrations concentrations|compound|END_ENTITY	Plasma catecholamines , thrombocyte alpha 2 - and lymphocyte beta_2-adrenoceptor densities in hypertensive patients with low or normal plasma renin concentrations .
8156394	0	catecholamines	6,20	renin	54,59	catecholamines	renin	MESH:D002395	24715(Tax:10116)	Chemical	Gene	START_ENTITY|xcomp|mediate mediate|dobj|reduction reduction|nmod|release release|compound|END_ENTITY	Brain catecholamines mediate the delayed reduction in renin release after injection of fenfluramine .
895008	0	catecholamines	79,93	renin	38,43	catecholamines	renin	MESH:D002395	5972	Chemical	Gene	START_ENTITY|nsubj|Interrelations Interrelations|nmod|END_ENTITY	Interrelations between age and plasma renin , aldosterone and cortisol , urinary catecholamines , and the body sodium/volume state in normal man .
9301	2	catecholamines	110,124	renin	136,141	catecholamines	renin	MESH:D002395	5972	Chemical	Gene	START_ENTITY|dobj|activity activity|compound|END_ENTITY	Effect on the response of plasma catecholamines and plasma renin activity to insulin-induced hypoglycemia .
998517	0	catecholamines	17,31	renin	40,45	catecholamines	renin	MESH:D002395	5972	Chemical	Gene	START_ENTITY|nmod|hypertension hypertension|compound|END_ENTITY	Increased plasma catecholamines in high renin hypertension .
6145120	0	catecholamines	39,53	somatostatin	14,26	catecholamines	somatostatin	MESH:D002395	24797(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of somatostatin on striatal catecholamines .
18234565	0	catecholamines	20,34	tumor_necrosis_factor_alpha	38,65	catecholamines	tumor necrosis factor alpha	MESH:D002395	7124	Chemical	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	Effect of exogenous catecholamines on tumor_necrosis_factor_alpha , interleukin-6 , interleukin-10 and beta-endorphin levels following severe trauma .
9095470	0	catecholamines	146,160	tumor_necrosis_factor_alpha	63,90	catecholamines	tumor necrosis factor alpha	MESH:D002395	24835(Tax:10116)	Chemical	Gene	attenuates|nmod|START_ENTITY attenuates|nsubj|exposure exposure|nmod|cardiomyocytes cardiomyocytes|nmod|concentrations concentrations|nmod|END_ENTITY	Subchronic exposure of cardiomyocytes to low concentrations of tumor_necrosis_factor_alpha attenuates the positive inotropic response not only to catecholamines but also to cardiac glycosides and high calcium concentrations .
14758053	0	catecholamines	75,89	tyrosine_hydroxylase	14,34	catecholamines	tyrosine hydroxylase	MESH:D002395	7054	Chemical	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of tyrosine_hydroxylase in lymphocytes and effect of endogenous catecholamines on lymphocyte function .
15287903	0	catecholamines	61,75	tyrosine_hydroxylase	89,109	catecholamines	tyrosine hydroxylase	MESH:D002395	7054	Chemical	Gene	START_ENTITY|nmod|isoforms isoforms|amod|END_ENTITY	Effects of phosphorylation by protein kinase A on binding of catecholamines to the human tyrosine_hydroxylase isoforms .
16985181	0	catecholamines	99,113	tyrosine_hydroxylase	55,75	catecholamines	tyrosine hydroxylase	MESH:D002395	7054	Chemical	Gene	express|dobj|START_ENTITY express|dobj|END_ENTITY	Human CD4 + CD25 + regulatory T cells selectively express tyrosine_hydroxylase and contain endogenous catecholamines subserving an autocrine/paracrine inhibitory functional loop .
19396395	0	catecholamines	66,80	tyrosine_hydroxylase	22,42	catecholamines	tyrosine hydroxylase	MESH:D002395	7054	Chemical	Gene	biosynthesis|nmod|START_ENTITY Role|nmod|biosynthesis Role|nmod|END_ENTITY	Role of N-terminus of tyrosine_hydroxylase in the biosynthesis of catecholamines .
22583429	0	catecholamines	27,41	tyrosine_hydroxylase	89,109	catecholamines	tyrosine hydroxylase	MESH:D002395	7054	Chemical	Gene	study|nmod|START_ENTITY Molecular|dobj|study Molecular|dep|phenyl phenyl|acl|carbamic_acid carbamic_acid|nmod|END_ENTITY	Molecular docking study of catecholamines and -LSB- 4 - -LRB- propan-2-yl -RRB- _ phenyl -RSB- carbamic_acid with tyrosine_hydroxylase .
6151148	0	catecholamines	16,30	tyrosine_hydroxylase	166,186	catecholamines	tyrosine hydroxylase	MESH:D002395	7054	Chemical	Gene	Distribution|nmod|START_ENTITY Distribution|dep|study study|acl|based based|xcomp|END_ENTITY	Distribution of catecholamines in the brain stem and spinal cord of the lizard Varanus exanthematicus : an immunohistochemical study based on the use of antibodies to tyrosine_hydroxylase .
7715703	0	catecholamines	66,80	tyrosine_hydroxylase	27,47	catecholamines	tyrosine hydroxylase	MESH:D002395	21823(Tax:10090)	Chemical	Gene	required|nsubjpass|START_ENTITY reveals|ccomp|required reveals|nsubj|disruption disruption|nmod|gene gene|amod|END_ENTITY	Targeted disruption of the tyrosine_hydroxylase gene reveals that catecholamines are required for mouse fetal development .
9973233	0	catecholamines	112,126	tyrosine_hydroxylase	77,97	catecholamines	tyrosine hydroxylase	MESH:D002395	25085(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Differential effects of chemical sympathectomy on expression and activity of tyrosine_hydroxylase and levels of catecholamines and DOPA in peripheral tissues of rats .
7727409	0	catecholate	27,38	tyrosine_hydroxylase	84,104	catecholate	tyrosine hydroxylase	CHEBI:32402	7054	Chemical	Gene	complexes|amod|START_ENTITY complexes|nmod|END_ENTITY	Resonance Raman studies of catecholate and phenolate complexes of recombinant human tyrosine_hydroxylase .
12083324	0	catechols	92,101	Catechol-O-Methyltransferase	0,28	catechols	Catechol-O-Methyltransferase	MESH:D002396	1312	Chemical	Gene	metabolism|nmod|START_ENTITY END_ENTITY|dep|metabolism	Catechol-O-Methyltransferase -LRB- COMT -RRB- - mediated methylation metabolism of endogenous bioactive catechols and modulation by endobiotics and xenobiotics : importance in pathophysiology and pathogenesis .
9749372	0	catechols	83,92	catechol_O-methyltransferase	39,67	catechols	catechol O-methyltransferase	MESH:D002396	1312	Chemical	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	A semiempirical study on inhibition of catechol_O-methyltransferase by substituted catechols .
26552046	0	catestatin	34,44	SGLT1	25,30	catestatin	SGLT1	null	20537(Tax:10090)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of intestinal SGLT1 by catestatin in hyperleptinemic_type_2 diabetic mice .
24275046	0	cathinones	84,94	Monoamine_transporter	0,21	cathinones	Monoamine transporter	null	6571	Chemical	Gene	START_ENTITY|nsubj|profiles profiles|compound|END_ENTITY	Monoamine_transporter and receptor interaction profiles of a new series of designer cathinones .
7962086	0	caveolin	13,21	GLUT4	61,66	caveolin	GLUT4	null	6517	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of caveolin during adipogenesis and association of GLUT4 with caveolin-rich vesicles .
22900022	0	caveolin	21,29	TC10	0,4	caveolin	TC10	null	23433	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	TC10 is regulated by caveolin in 3T3-L1 adipocytes .
21523467	0	cavtratin	10,19	caveolin-1	23,33	cavtratin	caveolin-1	null	857	Chemical	Gene	START_ENTITY|appos|peptide peptide|amod|END_ENTITY	Effect of cavtratin , a caveolin-1 scaffolding domain peptide , on oligodendroglial signaling cascades .
21964533	0	cediranib	18,27	S0509	82,87	cediranib	S0509	MESH:C500926	1076944(Tax:198215)	Chemical	Gene	study|nmod|START_ENTITY study|dep|END_ENTITY	Phase II study of cediranib in patients with malignant_pleural_mesothelioma : SWOG S0509 .
21989836	0	cediranib	28,37	VEGF	60,64	cediranib	VEGF	MESH:C500926	7422	Chemical	Gene	study|nmod|START_ENTITY Phase|xcomp|study signalling|advcl|Phase signalling|nsubj|inhibitor inhibitor|nmod|END_ENTITY	Phase I open-label study of cediranib , an oral inhibitor of VEGF signalling , in combination with the oral Src inhibitor saracatinib in patients with advanced solid tumours .
23197081	0	cediranib	37,46	VEGF	57,61	cediranib	VEGF	MESH:C500926	7422	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Pharmacokinetics and tolerability of cediranib , a potent VEGF signalling inhibitor , in cancer patients with hepatic_impairment .
23449351	0	cediranib	84,93	VEGF	35,39	cediranib	VEGF	MESH:C500926	7422	Chemical	Gene	comparing|xcomp|START_ENTITY value|acl|comparing value|nmod|END_ENTITY	Prognostic and predictive value of VEGF , sVEGFR-2 and CEA in mCRC studies comparing cediranib , bevacizumab and chemotherapy .
26841902	0	cediranib	20,29	VEGF	39,43	cediranib	VEGF	MESH:C500926	7422	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	A phase II study of cediranib , an oral VEGF inhibitor , in previously untreated patients with metastatic or recurrent malignant_melanoma .
20061136	0	cediranib	22,31	VEGFR	45,50	cediranib	VEGFR	MESH:C500926	3791	Chemical	Gene	evaluation|nmod|START_ENTITY evaluation|appos|END_ENTITY	Phase I evaluation of cediranib , a selective VEGFR signalling inhibitor , in combination with gefitinib in patients with advanced tumours .
18687659	0	cediranib	108,117	VEGFR-2	70,77	cediranib	VEGFR-2	MESH:C500926	3791	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Differential response of primary_tumor versus lymphatic metastasis to VEGFR-2 and VEGFR-3 kinase inhibitors cediranib and vandetanib .
18819995	0	cediranib	66,75	vascular_endothelial_growth_factor	14,48	cediranib	vascular endothelial growth factor	MESH:C500926	22339(Tax:10090)	Chemical	Gene	using|dobj|START_ENTITY signalling|advcl|using END_ENTITY|acl|signalling	Inhibition of vascular_endothelial_growth_factor signalling using cediranib -LRB- RECENTIN ; AZD2171 -RRB- enhances radiation response and causes substantial physiological changes in lung_tumour xenografts .
19091548	0	cediranib	50,59	vascular_endothelial_growth_factor	77,111	cediranib	vascular endothelial growth factor	MESH:C500926	7422	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|kinases kinases|compound|END_ENTITY	A phase I and pharmacokinetic study of daily oral cediranib , an inhibitor of vascular_endothelial_growth_factor tyrosine kinases , in combination with cisplatin and gemcitabine in patients with advanced non-small_cell_lung_cancer : a study of the National Cancer Institute of Canada Clinical Trials Group .
20056761	0	cediranib	55,64	vascular_endothelial_growth_factor	74,108	cediranib	vascular endothelial growth factor	MESH:C500926	7422	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Rapid development of hypertension and proteinuria with cediranib , an oral vascular_endothelial_growth_factor receptor inhibitor .
20634336	0	cediranib	31,40	vascular_endothelial_growth_factor	51,85	cediranib	vascular endothelial growth factor	MESH:C500926	7422	Chemical	Gene	metabolism|nmod|START_ENTITY tyrosine|nmod|metabolism tyrosine|nsubj|END_ENTITY	In vitro hepatic metabolism of cediranib , a potent vascular_endothelial_growth_factor tyrosine kinase inhibitor : interspecies comparison and human enzymology .
24752867	0	cediranib	119,128	vascular_endothelial_growth_factor	23,57	cediranib	vascular endothelial growth factor	MESH:C500926	7422	Chemical	Gene	bevacizumab|appos|START_ENTITY evaluating|dobj|bevacizumab trial|acl|evaluating inhibition|dep|trial inhibition|nmod|pathway pathway|compound|END_ENTITY	Dual inhibition of the vascular_endothelial_growth_factor pathway : a phase 1 trial evaluating bevacizumab and AZD2171 -LRB- cediranib -RRB- in patients with advanced solid tumors .
2161822	0	cefadroxil	83,93	leukotriene_B4_receptor	24,47	cefadroxil	leukotriene B4 receptor	MESH:D002434	1241	Chemical	Gene	enhancement|nmod|START_ENTITY enhancement|nmod|expression expression|amod|END_ENTITY	In-vitro enhancement of leukotriene_B4_receptor expression on human neutrophils by cefadroxil .
26776155	0	cefatrizine	81,92	eEF2K	64,69	cefatrizine	eEF2K	MESH:D002436	29904	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Integrative bioinformatics and proteomics-based discovery of an eEF2K inhibitor -LRB- cefatrizine -RRB- with ER stress modulation in breast_cancer cells .
6111670	0	cefazolin	13,22	hip	47,50	cefazolin	hip	MESH:D002437	6159	Chemical	Gene	START_ENTITY|nmod|replacement replacement|compound|END_ENTITY	Prophylactic cefazolin versus placebo in total hip replacement .
3189097	0	cefazolin_sodium	53,69	ERG	12,15	cefazolin sodium	ERG	MESH:D002437	2078	Chemical	Gene	-RSB-|compound|START_ENTITY Effects|nmod|-RSB- Effects|nmod|END_ENTITY	-LSB- Effects on ERG and VEP of intravitreal injection of cefazolin_sodium -RSB- .
6620567	0	cefbuperazone	31,44	T-1982	23,29	cefbuperazone	T-1982	MESH:C035978	1069037(Tax:209261)	Chemical	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	-LSB- Therapeutic effect of T-1982 -LRB- cefbuperazone -RRB- on the gynecologic infectious_diseases -RSB- .
8589159	0	cefixime	40,48	group_A_streptococci	101,121	cefixime	group A streptococci	MESH:D020682	2588	Chemical	Gene	Evaluation|nmod|START_ENTITY Evaluation|nmod|END_ENTITY	Evaluation of short-course therapy with cefixime or rifampin for eradication of pharyngeally carried group_A_streptococci .
6941956	0	cefmenoxime	42,53	SCE-1365	55,63	cefmenoxime	SCE-1365	MESH:D015281	5814103(Tax:448385)	Chemical	Gene	distribution|nmod|START_ENTITY distribution|appos|END_ENTITY	Absorption , distribution and excretion of cefmenoxime -LRB- SCE-1365 -RRB- , a novel broad-spectrum cephalosporin , in mice , rats , rabbits and dogs .
11599481	0	cefodizime	44,54	tumor_necrosis_factor-alpha	13,40	cefodizime	tumor necrosis factor-alpha	MESH:C033356	7124	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of tumor_necrosis_factor-alpha by cefodizime in U-937 cells .
12878518	0	cefotaxime	114,124	bla	23,26	cefotaxime	bla	MESH:D002439	3244915(Tax:562)	Chemical	Gene	inhibitors|amod|START_ENTITY mutations|nmod|inhibitors mutations|nsubj|END_ENTITY	Haemophilus_influenzae bla -LRB- ROB-1 -RRB- mutations in hypermutagenic deltaampC Escherichia_coli conferring resistance to cefotaxime and beta-lactamase inhibitors and increased susceptibility to cefaclor .
26342770	0	cefotaxime	22,32	tyrosinase	61,71	cefotaxime	tyrosinase	MESH:D002439	7299	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nsubj|effects	Inhibitory effects of cefotaxime on the activity of mushroom tyrosinase .
10443470	0	cefroxadine	79,90	angiotensin-converting_enzyme	35,64	cefroxadine	angiotensin-converting enzyme	MESH:C012671	100009274(Tax:9986)	Chemical	Gene	inhibitors|nmod|START_ENTITY inhibitors|amod|END_ENTITY	pH-dependent inhibitory effects of angiotensin-converting_enzyme inhibitors on cefroxadine uptake by rabbit small intestinal brush-border membrane vesicles and their relationship with hydrophobicity and the ratio of zwitterionic species .
9145229	0	cefroxadine	65,76	angiotensin-converting_enzyme	22,51	cefroxadine	angiotensin-converting enzyme	MESH:C012671	100009274(Tax:9986)	Chemical	Gene	inhibitor|nmod|START_ENTITY inhibitor|amod|END_ENTITY	Inhibitory effects of angiotensin-converting_enzyme inhibitor on cefroxadine uptake by rabbit small intestinal brush border membrane vesicles .
21536061	0	ceftriaxone	104,115	GLT-1	8,13	ceftriaxone	GLT-1	MESH:D002443	20511(Tax:10090)	Chemical	Gene	antibiotic|appos|START_ENTITY activation|nmod|antibiotic activation|nsubj|Role Role|nmod|transporter transporter|compound|END_ENTITY	Role of GLT-1 transporter activation in prevention of cannabinoid tolerance by the b-lactam antibiotic , ceftriaxone , in mice .
23628489	0	ceftriaxone	18,29	GLT-1	33,38	ceftriaxone	GLT-1	MESH:D002443	20511(Tax:10090)	Chemical	Gene	START_ENTITY|appos|activator activator|compound|END_ENTITY	Lack of effect of ceftriaxone , a GLT-1 transporter activator , on spatial memory in mice .
23973312	0	ceftriaxone	8,19	GLT-1	105,110	ceftriaxone	GLT-1	MESH:D002443	20511(Tax:10090)	Chemical	Gene	treatment|compound|START_ENTITY rescues|nsubj|treatment rescues|nmod|mice mice|nmod|activation activation|nmod|END_ENTITY	Chronic ceftriaxone treatment rescues hippocampal memory_deficit in AQP4 knockout mice via activation of GLT-1 .
24123246	0	ceftriaxone	40,51	GLT-1	16,21	ceftriaxone	GLT-1	MESH:D002443	29482(Tax:10116)	Chemical	Gene	treatment|nmod|START_ENTITY END_ENTITY|nmod|treatment	Upregulation of GLT-1 by treatment with ceftriaxone alleviates radicular_pain by reducing spinal astrocyte activation and neuronal_hyperexcitability .
25806702	0	ceftriaxone	82,93	GLT-1	61,66	ceftriaxone	GLT-1	MESH:D002443	29482(Tax:10116)	Chemical	Gene	challenge|nmod|START_ENTITY challenge|compound|END_ENTITY	Imaging in vivo glutamate fluctuations with -LSB- -LRB- 11 -RRB- C -RSB- ABP688 : a GLT-1 challenge with ceftriaxone .
27060486	0	ceftriaxone	11,22	GLT-1	118,123	ceftriaxone	GLT-1	MESH:D002443	29482(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY _|nsubj|Effects _|nmod|expression expression|compound|END_ENTITY	Effects of ceftriaxone on ethanol , nicotine or sucrose intake by alcohol-preferring -LRB- P -RRB- _ rats and its association with GLT-1 expression .
22877649	0	celastrol	56,65	Beta-catenin	0,12	celastrol	Beta-catenin	MESH:C050414	1499	Chemical	Gene	effect|nmod|START_ENTITY mediates|dobj|effect mediates|nsubj|END_ENTITY	Beta-catenin mediates the apoptosis induction effect of celastrol in HT29 cells .
20398364	0	celastrol	17,26	HSP90	0,5	celastrol	HSP90	MESH:C050414	3320	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|nummod|END_ENTITY	HSP90 inhibitor , celastrol , arrests human monocytic_leukemia cell U937 at G0/G1 in thiol-containing agents reversible way .
21249311	0	celastrol	61,70	Hsp90	100,105	celastrol	Hsp90	MESH:C050414	3320	Chemical	Gene	cells|nmod|START_ENTITY sensitivity|nmod|cells Enhancement|nmod|sensitivity mediated|nsubjpass|Enhancement mediated|nmod|inhibition inhibition|nmod|END_ENTITY	Enhancement of radiation sensitivity in lung_cancer cells by celastrol is mediated by inhibition of Hsp90 .
16984800	0	celastrol	74,83	NF-kappa_B	14,24	celastrol	NF-kappa B	MESH:C050414	4790	Chemical	Gene	kinase|nmod|START_ENTITY a_quinone_methide_triterpenoid|parataxis|kinase a_quinone_methide_triterpenoid|nsubj|Inhibition Inhibition|nmod|activation activation|amod|END_ENTITY	Inhibition of NF-kappa_B activation through targeting I kappa B kinase by celastrol , a_quinone_methide_triterpenoid .
19778460	0	celastrol	26,35	NF-kappa_B	4,14	celastrol	NF-kappa B	MESH:C050414	4790	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	The NF-kappa_B inhibitor , celastrol , could enhance the anti-cancer effect of gambogic_acid on oral_squamous_cell_carcinoma .
24755677	0	celastrol	37,46	NF-kappa_B	0,10	celastrol	NF-kappa B	MESH:C050414	4790	Chemical	Gene	apoptosis|amod|START_ENTITY involved|nmod|apoptosis involved|nsubjpass|modulation modulation|amod|END_ENTITY	NF-kappa_B modulation is involved in celastrol induced human multiple_myeloma cell apoptosis .
20605676	0	celastrol	43,52	death_receptor_4	17,33	celastrol	death receptor 4	MESH:C050414	8797	Chemical	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|END_ENTITY	Up-regulation of death_receptor_4 and 5 by celastrol enhances the anti-cancer activity of TRAIL/Apo -2 L .
19858214	0	celastrol	20,29	hsp90	41,46	celastrol	hsp90	MESH:C050414	3320	Chemical	Gene	Characterization|nmod|START_ENTITY Characterization|acl|inhibit inhibit|dobj|interaction interaction|amod|END_ENTITY	Characterization of celastrol to inhibit hsp90 and cdc37 interaction .
14558947	0	celebrex	48,56	VEGF	110,114	celebrex	VEGF	MESH:C105934	22339(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	-LSB- Effect of selective cyclooxygenase-2 inhibitor celebrex on expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in pancreatic_carcinoma -RSB- .
14558947	0	celebrex	48,56	vascular_endothelial_growth_factor	74,108	celebrex	vascular endothelial growth factor	MESH:C105934	22339(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of selective cyclooxygenase-2 inhibitor celebrex on expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in pancreatic_carcinoma -RSB- .
17121918	0	celecoxib	73,82	5-lipoxygenase	14,28	celecoxib	5-lipoxygenase	MESH:C105934	240	Chemical	Gene	activity|nmod|START_ENTITY augments|dobj|activity augments|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of 5-lipoxygenase by MK886 augments the antitumor activity of celecoxib in human colon_cancer cells .
18945614	0	celecoxib	13,22	5-lipoxygenase	70,84	celecoxib	5-lipoxygenase	MESH:C105934	240	Chemical	Gene	analogs|amod|START_ENTITY Synthesis|nmod|analogs Synthesis|acl:relcl|possess possess|dobj|N-hydroxypyrid-2 N-hydroxypyrid-2|amod|pharmacophore pharmacophore|nmod:npmod|END_ENTITY	Synthesis of celecoxib analogs that possess a N-hydroxypyrid-2 -LRB- 1H -RRB- one 5-lipoxygenase pharmacophore : biological evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity .
19296694	0	celecoxib	13,22	5-lipoxygenase	86,100	celecoxib	5-lipoxygenase	MESH:C105934	240	Chemical	Gene	Synthesis|nmod|START_ENTITY analogues|nsubj|Synthesis analogues|xcomp|possessing possessing|dobj|N-difluoromethyl-1 N-difluoromethyl-1|dep|pharmacophore pharmacophore|amod|END_ENTITY	Synthesis of celecoxib analogues possessing a N-difluoromethyl-1 ,2 - dihydropyrid-2-one 5-lipoxygenase pharmacophore : biological evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity .
19336727	0	celecoxib	111,120	5-lipoxygenase	154,168	celecoxib	5-lipoxygenase	MESH:C105934	240	Chemical	Gene	shunts|compound|START_ENTITY arachidonic_acid|nsubj|shunts arachidonic_acid|nmod|pathway pathway|amod|END_ENTITY	Levels of prostaglandin_E metabolite and leukotriene_E -LRB- 4 -RRB- are increased in the urine of smokers : evidence that celecoxib shunts arachidonic_acid into the 5-lipoxygenase pathway .
23679684	0	celecoxib	11,20	AKT	40,43	celecoxib	AKT	MESH:C105934	207	Chemical	Gene	treatment|amod|START_ENTITY Effects|nmod|treatment Effects|nmod|pathway pathway|compound|END_ENTITY	Effects of celecoxib treatment over the AKT pathway in head_and_neck_squamous_cell_carcinoma .
10753955	0	celecoxib	31,40	Akt	71,74	celecoxib	Akt	MESH:C105934	207	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|blocking blocking|dobj|activation activation|compound|END_ENTITY	The cyclooxygenase-2 inhibitor celecoxib induces apoptosis by blocking Akt activation in human prostate_cancer cells independently of Bcl-2 .
14973075	0	celecoxib	119,128	Akt	46,49	celecoxib	Akt	MESH:C105934	207	Chemical	Gene	target|nmod|START_ENTITY represents|dobj|target represents|nsubj|signaling signaling|compound|END_ENTITY	3-phosphoinositide-dependent_protein_kinase-1 / Akt signaling represents a major cyclooxygenase-2-independent target for celecoxib in prostate_cancer cells .
15026550	0	celecoxib	31,40	Akt	67,70	celecoxib	Akt	MESH:C105934	207	Chemical	Gene	blocks|nsubj|START_ENTITY blocks|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	The cyclooxygenase-2 inhibitor celecoxib blocks phosphorylation of Akt and induces apoptosis in human cholangiocarcinoma cells .
18823436	0	celecoxib	31,40	Akt	93,96	celecoxib	Akt	MESH:C105934	207	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|signaling signaling|compound|END_ENTITY	Anti-gastric_cancer effects of celecoxib , a selective COX-2 inhibitor , through inhibition of Akt signaling .
10753955	0	celecoxib	31,40	Bcl-2	134,139	celecoxib	Bcl-2	MESH:C105934	596	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|blocking blocking|nmod|cells cells|nmod|END_ENTITY	The cyclooxygenase-2 inhibitor celecoxib induces apoptosis by blocking Akt activation in human prostate_cancer cells independently of Bcl-2 .
21816845	0	celecoxib	63,72	C-reactive_protein	0,18	celecoxib	C-reactive protein	MESH:C105934	1401	Chemical	Gene	treatment|amod|START_ENTITY END_ENTITY|nmod|treatment	C-reactive_protein and risk of colorectal_adenoma according to celecoxib treatment .
10225538	0	celecoxib	37,46	COX-2	63,68	celecoxib	COX-2	MESH:C105934	4513	Chemical	Gene	Update|nmod|START_ENTITY Update|dobj|inhibitor inhibitor|compound|END_ENTITY	Update on clinical developments with celecoxib , a new specific COX-2 inhibitor : what can we expect ?
10422544	0	celecoxib	37,46	COX-2	63,68	celecoxib	COX-2	MESH:C105934	4513	Chemical	Gene	Update|nmod|START_ENTITY Update|dobj|inhibitor inhibitor|compound|END_ENTITY	Update on clinical developments with celecoxib , a new specific COX-2 inhibitor : what can we expect ?
10925968	0	celecoxib	64,73	COX-2	83,88	celecoxib	COX-2	MESH:C105934	4513	Chemical	Gene	ulcer_complications|nmod|START_ENTITY risk|nmod|ulcer_complications inhibitor|ccomp|risk inhibitor|nsubj|END_ENTITY	Reduced risk of upper gastrointestinal ulcer_complications with celecoxib , a novel COX-2 inhibitor .
10955327	0	celecoxib	39,48	COX-2	52,57	celecoxib	COX-2	MESH:C105934	4513	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|specific specific|amod|END_ENTITY	Upper gastrointestinal tolerability of celecoxib , a COX-2 specific inhibitor , compared to naproxen and placebo .
11412976	0	celecoxib	54,63	COX-2	27,32	celecoxib	COX-2	MESH:C105934	4513	Chemical	Gene	simulations|amod|START_ENTITY selectivity|nmod|simulations Rationale|dep|selectivity Rationale|nmod|END_ENTITY	Rationale for the observed COX-2 / COX-1 selectivity of celecoxib from Monte Carlo simulations .
11520213	0	celecoxib	24,33	COX-2	89,94	celecoxib	COX-2	MESH:C105934	5743	Chemical	Gene	analogues|amod|START_ENTITY analogues|nmod|inhibitors inhibitors|appos|END_ENTITY	Design and synthesis of celecoxib and rofecoxib analogues as selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors : replacement of sulfonamide and methylsulfonyl pharmacophores by an azido bioisostere .
11606477	0	celecoxib	118,127	COX-2	0,5	celecoxib	COX-2	MESH:C105934	19225(Tax:10090)	Chemical	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	COX-2 independent induction of cell cycle arrest and apoptosis in colon_cancer cells by the selective COX-2 inhibitor celecoxib .
11814774	0	celecoxib	37,46	COX-2	62,67	celecoxib	COX-2	MESH:C105934	4513	Chemical	Gene	affinities|nmod|START_ENTITY Estimation|nmod|affinities analogues|nsubj|Estimation analogues|nmod|END_ENTITY	Estimation of binding affinities for celecoxib analogues with COX-2 via Monte Carlo-extended linear response .
11848504	0	celecoxib	46,55	COX-2	29,34	celecoxib	COX-2	MESH:C105934	26198(Tax:10116)	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|END_ENTITY	Dose-response effects of the COX-2 inhibitor , celecoxib , on the chemoprevention of mammary carcinogenesis .
11911965	0	celecoxib	96,105	COX-2	36,41	celecoxib	COX-2	MESH:C105934	5743	Chemical	Gene	effect|nmod|START_ENTITY Overexpression|dep|effect Overexpression|nmod|END_ENTITY	Overexpression of cyclooxygenase-2 -LRB- COX-2 -RRB- in human primitive neuroectodermal_tumors : effect of celecoxib and rofecoxib .
12008128	0	celecoxib	17,26	COX-2	30,35	celecoxib	COX-2	MESH:C105934	4513	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Determination of celecoxib , a COX-2 inhibitor , in pharmaceutical dosage forms by MEKC .
12558194	0	celecoxib	42,51	COX-2	24,29	celecoxib	COX-2	MESH:C105934	29527(Tax:10116)	Chemical	Gene	inhibitors|dep|START_ENTITY inhibitors|nsubj|Effect Effect|nmod|END_ENTITY	Effect of the selective COX-2 inhibitors , celecoxib and rofecoxib in rat acute models of inflammation .
14500353	0	celecoxib	50,59	COX-2	14,19	celecoxib	COX-2	MESH:C105934	4513	Chemical	Gene	lines|nmod|START_ENTITY END_ENTITY|nmod|lines	Inhibition of COX-2 in colon_cancer cell lines by celecoxib increases the nuclear localization of active p53 .
14604691	0	celecoxib	30,39	COX-2	81,86	celecoxib	COX-2	MESH:C105934	5743	Chemical	Gene	analogues|compound|START_ENTITY analogues|nmod|inhibitors inhibitors|appos|END_ENTITY	Design and synthesis of novel celecoxib analogues as selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors : replacement of the sulfonamide pharmacophore by a sulfonylazide bioisostere .
14698190	0	celecoxib	54,63	COX-2	108,113	celecoxib	COX-2	MESH:C105934	4513	Chemical	Gene	ring|nmod|START_ENTITY substitutions|nmod|ring afford|nsubj|substitutions afford|dobj|class class|nmod|inhibitors inhibitors|compound|END_ENTITY	Polar substitutions in the benzenesulfonamide ring of celecoxib afford a potent 1,5-diarylpyrazole class of COX-2 inhibitors .
15041464	0	celecoxib	80,89	COX-2	18,23	celecoxib	COX-2	MESH:C105934	5743	Chemical	Gene	effects|nmod|START_ENTITY Cyclooxygenase-2|dep|effects Cyclooxygenase-2|appos|END_ENTITY	Cyclooxygenase-2 -LRB- COX-2 -RRB- - dependent and - independent anticarcinogenic effects of celecoxib in human colon_carcinoma cells .
15193741	0	celecoxib	59,68	COX-2	72,77	celecoxib	COX-2	MESH:C105934	4513	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Isolation , synthesis and characterization of impurities in celecoxib , a COX-2 inhibitor .
15194006	0	celecoxib	42,51	COX-2	25,30	celecoxib	COX-2	MESH:C105934	4513	Chemical	Gene	inhibitors|xcomp|START_ENTITY inhibitors|nsubj|Effects Effects|nmod|END_ENTITY	Effects of the selective COX-2 inhibitors celecoxib and rofecoxib on human vascular cells .
15237269	0	celecoxib	111,120	COX-2	131,136	celecoxib	COX-2	MESH:C105934	4513	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Acute generalized exanthematic pustulosis : a case and an overview of side effects affecting the skin caused by celecoxib and other COX-2 inhibitors reported so far .
15265936	0	celecoxib	33,42	COX-2	226,231	celecoxib	COX-2	MESH:C105934	5743	Chemical	Gene	abrogates|nsubj|START_ENTITY _|acl:relcl|abrogates _|dep|correlation correlation|nmod|suppression suppression|nmod|synthesis synthesis|compound|END_ENTITY	Cyclooxygenase _ -LRB- COX -RRB- -2 inhibitor celecoxib abrogates TNF-induced NF-kappa_B activation through inhibition of activation of I_kappa_B_alpha kinase and Akt in human non-small_cell_lung_carcinoma : correlation with suppression of COX-2 synthesis .
15612245	0	celecoxib	56,65	COX-2	39,44	celecoxib	COX-2	MESH:C105934	26198(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Effects and mechanism of the selective COX-2 inhibitor , celecoxib , on rat colitis induced by trinitrobenzene_sulfonic_acid .
15792784	0	celecoxib	63,72	COX-2	47,52	celecoxib	COX-2	MESH:C105934	26198(Tax:10116)	Chemical	Gene	retention|amod|START_ENTITY inhibitor|dobj|retention inhibitor|nsubj|infusion infusion|nmod|END_ENTITY	Post-training intrahippocampal infusion of the COX-2 inhibitor celecoxib impaired spatial memory retention in rats .
16175586	0	celecoxib	56,65	COX-2	119,124	celecoxib	COX-2	MESH:C105934	19225(Tax:10090)	Chemical	Gene	inhibition|nmod|START_ENTITY Adenocarcina|nmod|inhibition Adenocarcina|dep|downregulation downregulation|nmod|factors factors|acl|involved involved|nmod|inhibition inhibition|compound|END_ENTITY	Adenocarcina of the mouse prostate growth inhibition by celecoxib : downregulation of transcription factors involved in COX-2 inhibition .
16216692	0	celecoxib	82,91	COX-2	65,70	celecoxib	COX-2	MESH:C105934	17709(Tax:10090)	Chemical	Gene	Discrepancy|appos|START_ENTITY Discrepancy|nmod|effects effects|nmod|doses doses|nmod|inhibitor inhibitor|compound|END_ENTITY	Discrepancy between effects of milligram and nanogram doses of a COX-2 inhibitor -LRB- celecoxib -RRB- on morphine state-dependent memory of passive avoidance in mice .
16230415	0	celecoxib	32,41	COX-2	177,182	celecoxib	COX-2	MESH:C105934	4513	Chemical	Gene	enhancement|nmod|START_ENTITY enhancement|nmod|regulation regulation|nmod|cells cells|acl|expressing expressing|dobj|levels levels|compound|END_ENTITY	Radiosensitivity enhancement by celecoxib , a cyclooxygenase -LRB- COX -RRB- -2 selective inhibitor , via COX-2-dependent cell cycle regulation on human cancer cells expressing differential COX-2 levels .
16287921	0	celecoxib	23,32	COX-2	14,19	celecoxib	COX-2	MESH:C105934	804479(Tax:9615)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of COX-2 by celecoxib in the canine groove model of osteoarthritis .
16369983	0	celecoxib	54,63	COX-2	8,13	celecoxib	COX-2	MESH:C105934	5743	Chemical	Gene	immunostaining|nmod|START_ENTITY immunostaining|compound|END_ENTITY	Maximal COX-2 immunostaining and clinical response to celecoxib and interferon alpha therapy in metastatic renal_cell_carcinoma .
16384742	0	celecoxib	14,23	COX-2	37,42	celecoxib	COX-2	MESH:C105934	26198(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	The effect of celecoxib , a selective COX-2 inhibitor , on liver_ischemia / reperfusion-induced oxidative stress in rats .
16476713	0	celecoxib	168,177	COX-2	35,40	celecoxib	COX-2	MESH:C105934	4513	Chemical	Gene	profile|nmod|START_ENTITY cytokine|dobj|profile NSAID|parataxis|cytokine NSAID|ccomp|inhibits inhibits|dobj|synthesis synthesis|compound|END_ENTITY	Long term NSAID treatment inhibits COX-2 synthesis in the knee synovial membrane of patients with osteoarthritis : differential proinflammatory cytokine profile between celecoxib and aceclofenac .
16507397	0	celecoxib	121,130	COX-2	9,14	celecoxib	COX-2	MESH:C105934	5743	Chemical	Gene	treatment|amod|START_ENTITY predict|nmod|treatment expression|xcomp|predict expression|nsubj|Study Study|nmod|END_ENTITY	Study of COX-2 , Ki67 , and p53 expression to predict effectiveness of 5-flurouracil , epirubicin and cyclophosphamide with celecoxib treatment in breast_cancer patients .
16806914	0	celecoxib	69,78	COX-2	124,129	celecoxib	COX-2	MESH:C105934	5743	Chemical	Gene	derivatives|nmod|START_ENTITY Design|nmod|derivatives Design|nmod|inhibitors inhibitors|appos|END_ENTITY	Design and synthesis of new water-soluble tetrazolide derivatives of celecoxib and rofecoxib as selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors .
16827136	0	celecoxib	17,26	COX-2	0,5	celecoxib	COX-2	MESH:C105934	4513	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	COX-2 inhibitors celecoxib and rofecoxib prevent oxidative DNA fragmentation .
17037745	0	celecoxib	48,57	COX-2	93,98	celecoxib	COX-2	MESH:C105934	19225(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	-LSB- Effects of nonsteroidal anti-inflammatory drug celecoxib on expression of cyclooxygenase-2 -LRB- COX-2 -RRB- in ovarian_carcinoma cell -RSB- .
17305567	0	celecoxib	17,26	COX-2	0,5	celecoxib	COX-2	MESH:C105934	4513	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	COX-2 inhibitors celecoxib and parecoxib : valuable options for postoperative_pain management .
17409801	0	celecoxib	107,116	COX-2	138,143	celecoxib	COX-2	MESH:C105934	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|appos|END_ENTITY	Phase II study of gefitinib , an epidermal growth factor receptor tyrosine kinase inhibitor -LRB- EGFR-TKI -RRB- , and celecoxib , a cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitor , in patients with platinum refractory non-small_cell_lung_cancer -LRB- NSCLC -RRB- .
17608990	0	celecoxib	41,50	COX-2	24,29	celecoxib	COX-2	MESH:C105934	5743	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Review of the selective COX-2 inhibitors celecoxib and rofecoxib : focus on clinical aspects .
17685888	0	celecoxib	25,34	COX-2	38,43	celecoxib	COX-2	MESH:C105934	4513	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|selective selective|amod|END_ENTITY	Clinical pharmacology of celecoxib , a COX-2 selective inhibitor .
17713352	0	celecoxib	30,39	COX-2	14,19	celecoxib	COX-2	MESH:C105934	5743	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|Effect Effect|nmod|END_ENTITY	Effect of the COX-2 inhibitor celecoxib on behavioural and immune changes in an olfactory bulbectomised rat model of depression .
17936723	0	celecoxib	20,29	COX-2	130,135	celecoxib	COX-2	MESH:C105934	5743	Chemical	Gene	docetaxel|dep|START_ENTITY lines|amod|docetaxel Interaction|nmod|lines independent|nsubj|Interaction independent|nmod|levels levels|compound|END_ENTITY	Interaction between celecoxib and docetaxel or cisplatin in human cell lines of ovarian_cancer and colon_cancer is independent of COX-2 expression levels .
18083230	0	celecoxib	52,61	COX-2	100,105	celecoxib	COX-2	MESH:C105934	4513	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|dep|role role|nmod|END_ENTITY	Imatinib-resistant K562 cells are more sensitive to celecoxib , a selective COX-2 inhibitor : role of COX-2 and MDR-1 .
18083230	0	celecoxib	52,61	COX-2	75,80	celecoxib	COX-2	MESH:C105934	4513	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Imatinib-resistant K562 cells are more sensitive to celecoxib , a selective COX-2 inhibitor : role of COX-2 and MDR-1 .
18485224	0	celecoxib	57,66	COX-2	0,5	celecoxib	COX-2	MESH:C105934	4513	Chemical	Gene	necessary|nmod|START_ENTITY necessary|nsubj|inhibition inhibition|compound|END_ENTITY	COX-2 inhibition is neither necessary nor sufficient for celecoxib to suppress tumor cell proliferation and focus formation in vitro .
18711705	0	celecoxib	135,144	COX-2	68,73	celecoxib	COX-2	MESH:C105934	5743	Chemical	Gene	bleeding|nmod|START_ENTITY bleeding|nmod|users users|nmod|inhibitors inhibitors|compound|END_ENTITY	Hospitalization for peptic ulcer and bleeding in users of selective COX-2 inhibitors and nonselective NSAIDs with special reference to celecoxib .
18823436	0	celecoxib	31,40	COX-2	54,59	celecoxib	COX-2	MESH:C105934	4513	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Anti-gastric_cancer effects of celecoxib , a selective COX-2 inhibitor , through inhibition of Akt signaling .
18923901	0	celecoxib	21,30	COX-2	35,40	celecoxib	COX-2	MESH:C105934	5743	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|cells cells|amod|dependent dependent|amod|END_ENTITY	Anticancer effect of celecoxib via COX-2 dependent and independent mechanisms in human gastric_cancers cells .
19798548	0	celecoxib	15,24	COX-2	28,33	celecoxib	COX-2	MESH:C105934	26198(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|selective selective|amod|END_ENTITY	The effects of celecoxib , a COX-2 selective inhibitor , on acute inflammation induced in irradiated rats .
19949782	0	celecoxib	39,48	COX-2	22,27	celecoxib	COX-2	MESH:C105934	26198(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Preventive effects of COX-2 inhibitor , celecoxib on renal_tubular_injury induced by shock wave lithotriptor .
19949782	15	celecoxib	1351,1360	COX-2	1256,1261	celecoxib	COX-2	MESH:C105934	26198(Tax:10116)	Chemical	Gene	prevented|nmod|START_ENTITY group|acl:relcl|prevented increased|nmod|group increased|nsubjpass|expression expression|compound|END_ENTITY	However , the COX-2 gene expression was significantly increased in the control group , which was prevented by celecoxib in COX-2 group .
20004565	0	celecoxib	47,56	COX-2	0,5	celecoxib	COX-2	MESH:C105934	4513	Chemical	Gene	treatment|amod|START_ENTITY role|nmod|treatment expression|dep|role expression|compound|END_ENTITY	COX-2 expression in chondrosarcoma : a role for celecoxib treatment ?
20224826	0	celecoxib	51,60	COX-2	43,48	celecoxib	COX-2	MESH:C105934	5743	Chemical	Gene	cyclooxygenase-2|amod|START_ENTITY cyclooxygenase-2|appos|END_ENTITY	-LSB- Selective inhibitors of cyclooxygenase-2 -LRB- COX-2 -RRB- , celecoxib and parecoxib : a systematic review -RSB- .
20682995	0	celecoxib	60,69	COX-2	107,112	celecoxib	COX-2	MESH:C105934	4513	Chemical	Gene	derivative|nmod|START_ENTITY effect|nmod|derivative effect|dep|role role|nmod|END_ENTITY	Antiproliferative effect of a novel nitro-oxy derivative of celecoxib in human colon_cancer cells : role of COX-2 and nitric_oxide .
20698743	0	celecoxib	37,46	COX-2	20,25	celecoxib	COX-2	MESH:C105934	29527(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Effect of selective COX-2 inhibitor , celecoxib on adjuvant-induced_arthritis model in irradiated rats .
20809260	0	celecoxib	23,32	COX-2	84,89	celecoxib	COX-2	MESH:C105934	5743	Chemical	Gene	effects|nmod|START_ENTITY effects|acl|expressing expressing|dobj|oncoprotein oncoprotein|compound|END_ENTITY	Anti-cancer effects of celecoxib on nasopharyngeal_carcinoma HNE-1 cells expressing COX-2 oncoprotein .
21140284	0	celecoxib	45,54	COX-2	29,34	celecoxib	COX-2	MESH:C105934	4513	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|effects effects|nmod|END_ENTITY	Antiproliferative effects of COX-2 inhibitor celecoxib on human breast_cancer cell lines .
21939759	12	celecoxib	1735,1744	COX-2	1588,1593	celecoxib	COX-2	MESH:C105934	5743	Chemical	Gene	potency|dep|START_ENTITY exhibited|xcomp|potency derivative|acl|exhibited derivative|amod|scaffold scaffold|nmod|inhibitors inhibitors|compound|END_ENTITY	This study indicates that 4,5-bisaryl _ imidazolyl_imidazole is a suitable scaffold to design COX-2 inhibitors and 4,5-bis -LRB- 4-methoxyphenyl -RRB- -1 H-imidazol-2-yl derivative exhibited highly COX-2 inhibitory potency and selectivity even more than celecoxib .
22689176	0	celecoxib	87,96	COX-2	71,76	celecoxib	COX-2	MESH:C105934	5743	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|study study|acl|investigating investigating|dobj|addition addition|nmod|END_ENTITY	A randomized phase II study investigating the addition of the specific COX-2 inhibitor celecoxib to docetaxel plus carboplatin as first-line chemotherapy for stage IC to IV_epithelial_ovarian_cancer , Fallopian_tube_or_primary_peritoneal_carcinomas : the DoCaCel study .
23127498	1	celecoxib	204,213	COX-2	288,293	celecoxib	COX-2	MESH:C105934	19225(Tax:10090)	Chemical	Gene	influences|nsubj|START_ENTITY influences|dobj|contraction contraction|amod|independent independent|nmod|action action|nmod|END_ENTITY	This study aimed to determine whether a cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitor celecoxib influences endothelium-dependent contraction independent of its action on COX-2 and , if so , the underlying mechanism -LRB- s -RRB- .
23167625	0	celecoxib	27,36	COX-2	10,15	celecoxib	COX-2	MESH:C105934	4513	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Selective COX-2 inhibitor -LRB- celecoxib -RRB- decreases cellular growth in prostate_cancer cell lines independent of p53 .
23226798	0	celecoxib	50,59	COX-2	34,39	celecoxib	COX-2	MESH:C105934	19225(Tax:10090)	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|effect effect|nmod|END_ENTITY	Antitumor effect of the selective COX-2 inhibitor celecoxib on endometrial_adenocarcinoma in vitro and in vivo .
23385883	3	celecoxib	621,630	COX-2	634,639	celecoxib	COX-2	MESH:C105934	19225(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Here , we investigated the combinational effect by using pcDNA3 .1 -LRB- + -RRB- encoding mouse 15-PGDH gene therapy and celecoxib , a COX-2 inhibitor , in mouse breast_cancers .
24474408	0	celecoxib	39,48	COX-2	22,27	celecoxib	COX-2	MESH:C105934	4513	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Effect of a selective COX-2 inhibitor , celecoxib , on heterotopic_ossification after total_hip_arthroplasty : a case-controlled study .
24647425	0	celecoxib	49,58	COX-2	32,37	celecoxib	COX-2	MESH:C105934	19225(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Antitumor effect of a selective COX-2 inhibitor , celecoxib , may be attributed to angiogenesis inhibition through modulating the PTEN/PI3K/Akt / HIF-1 pathway in an H murine hepatocarcinoma model .
24656746	0	celecoxib	21,30	COX-2	34,39	celecoxib	COX-2	MESH:C105934	5743	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expressing expressing|compound|END_ENTITY	Antitumor effects of celecoxib in COX-2 expressing and non-expressing canine melanoma cell lines .
25218028	0	celecoxib	139,148	COX-2	0,5	celecoxib	COX-2	MESH:C105934	4513	Chemical	Gene	cell-mediated|nmod|START_ENTITY cell-mediated|nsubj|induction induction|amod|END_ENTITY	COX-2 - and endoplasmic reticulum stress-independent induction of ULBP-1 and enhancement of sensitivity to NK cell-mediated cytotoxicity by celecoxib in colon_cancer cells .
25860026	0	celecoxib	20,29	COX-2	101,106	celecoxib	COX-2	MESH:C105934	26198(Tax:10116)	Chemical	Gene	delivery|nmod|START_ENTITY strategy|nsubj|delivery strategy|acl|repositioning repositioning|dobj|inhibitor inhibitor|compound|END_ENTITY	Colonic delivery of celecoxib is a potential pharmaceutical strategy for repositioning the selective COX-2 inhibitor as an anti-colitic agent .
26950454	0	celecoxib	14,23	COX-2	113,118	celecoxib	COX-2	MESH:C105934	4513	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|Involvement Involvement|nmod|expression expression|amod|END_ENTITY	The effect of celecoxib and its combination with imatinib on human HT-29 colorectal_cancer cells : Involvement of COX-2 , Caspase-3 , VEGF and NF-kB genes expression .
14739610	2	celecoxib	292,301	Cox-2	243,248	celecoxib	Cox-2	MESH:C105934	4513	Chemical	Gene	analogue|nmod|START_ENTITY SC236|dep|analogue inhibitor|appos|SC236 inhibitor|compound|END_ENTITY	We studied the role of Cox-2 inhibition in apoptosis induced by a selective Cox-2 inhibitor , SC236 -LRB- a structural analogue of celecoxib -RRB- in two colon_cancer cell lines , HT29 -LRB- expressing Cox-2 protein -RRB- and HCT116 -LRB- not expressing Cox-2 protein -RRB- .
15791193	0	celecoxib	107,116	Cox-2	89,94	celecoxib	Cox-2	MESH:C105934	4513	Chemical	Gene	inhibitors|appos|START_ENTITY inhibitors|compound|END_ENTITY	-LSB- Prevention of heterotopic ossifications in hip arthroplasty : effectiveness of selective Cox-2 inhibitors -LRB- celecoxib -RRB- versus ketoprofen -RSB- .
22632102	0	celecoxib	27,36	Cox-2	134,139	celecoxib	Cox-2	MESH:C105934	4513	Chemical	Gene	delivery|nmod|START_ENTITY strategy|nsubj|delivery strategy|acl|improve improve|dobj|properties properties|nmod|inhibitor inhibitor|compound|END_ENTITY	Colon-specific delivery of celecoxib is a potential strategy to improve toxicological and pharmacological properties of the selective Cox-2 inhibitor : implication in treatment of familiar adenomatous_polyposis .
25107843	0	celecoxib	85,94	Cox-2	98,103	celecoxib	Cox-2	MESH:C105934	4513	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|selective selective|amod|END_ENTITY	The PI3K/Akt pathway in colitis associated colon_cancer and its chemoprevention with celecoxib , a Cox-2 selective inhibitor .
11304662	0	celecoxib	98,107	Cyclooxygenase-2	0,16	celecoxib	Cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	patients|amod|START_ENTITY trial|nmod|patients END_ENTITY|dep|trial	Cyclooxygenase-2 -- specific inhibitors and cardiorenal function : a randomized , controlled trial of celecoxib and rofecoxib in older hypertensive osteoarthritis patients .
11830509	0	celecoxib	31,40	Cyclooxygenase-2	0,16	celecoxib	Cyclooxygenase-2	MESH:C105934	29527(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Cyclooxygenase-2 inhibition by celecoxib reduces proliferation and induces apoptosis in angiogenic endothelial cells in vivo .
12384538	0	celecoxib	33,42	Cyclooxygenase-2	0,16	celecoxib	Cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Cyclooxygenase-2 inhibition with celecoxib enhances antitumor efficacy and reduces diarrhea side effect of CPT-11 .
12810622	0	celecoxib	42,51	Cyclooxygenase-2	0,16	celecoxib	Cyclooxygenase-2	MESH:C105934	19225(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Cyclooxygenase-2 expression and effect of celecoxib in gastric adenomas of trefoil_factor_1-deficient mice .
15041464	0	celecoxib	80,89	Cyclooxygenase-2	0,16	celecoxib	Cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|dep|effects	Cyclooxygenase-2 -LRB- COX-2 -RRB- - dependent and - independent anticarcinogenic effects of celecoxib in human colon_carcinoma cells .
16436115	0	celecoxib	42,51	Cyclooxygenase-2	0,16	celecoxib	Cyclooxygenase-2	MESH:C105934	29527(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Cyclooxygenase-2 expression and effect of celecoxib in flurothyl-induced neonatal_seizure .
16806953	0	celecoxib	28,37	Cyclooxygenase-2	0,16	celecoxib	Cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Cyclooxygenase-2 inhibitor , celecoxib , inhibits the altered hippocampal neurogenesis with attenuation of spontaneous recurrent seizures following pilocarpine-induced status_epilepticus .
19000324	0	celecoxib	25,34	Cyclooxygenase-2	113,129	celecoxib	Cyclooxygenase-2	MESH:C105934	19225(Tax:10090)	Chemical	Gene	enhancement|nmod|START_ENTITY enhancement|nmod|END_ENTITY	Antitumor enhancement of celecoxib , a selective Cyclooxygenase-2 inhibitor , in a Lewis_lung_carcinoma expressing Cyclooxygenase-2 .
19000324	0	celecoxib	25,34	Cyclooxygenase-2	48,64	celecoxib	Cyclooxygenase-2	MESH:C105934	19225(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Antitumor enhancement of celecoxib , a selective Cyclooxygenase-2 inhibitor , in a Lewis_lung_carcinoma expressing Cyclooxygenase-2 .
25001017	0	celecoxib	28,37	Cyclooxygenase-2	0,16	celecoxib	Cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Cyclooxygenase-2 inhibitor , celecoxib , inhibits leiomyoma cell proliferation through the nuclear factor kB pathway .
19233181	0	celecoxib	51,60	Cytochrome_P450_2C9	0,19	celecoxib	Cytochrome P450 2C9	MESH:C105934	1559	Chemical	Gene	influence|advcl|START_ENTITY influence|nsubj|variants variants|amod|END_ENTITY	Cytochrome_P450_2C9 variants influence response to celecoxib for prevention of colorectal_adenoma .
17224647	0	celecoxib	10,19	E-cadherin	23,33	celecoxib	E-cadherin	MESH:C105934	999	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of celecoxib on E-cadherin , VEGF , Microvessel density and apoptosis in gastric_cancer .
18303430	0	celecoxib	30,39	E-cadherin	184,194	celecoxib	E-cadherin	MESH:C105934	999	Chemical	Gene	response|nmod|START_ENTITY associated|nsubjpass|response associated|nmod|END_ENTITY	Tumor response to combination celecoxib and erlotinib therapy in non-small_cell_lung_cancer is associated with a low baseline matrix_metalloproteinase-9 and a decline in serum-soluble E-cadherin .
19622294	0	celecoxib	38,47	E-cadherin	92,102	celecoxib	E-cadherin	MESH:C105934	999	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Short-term preoperative treatment of celecoxib , a selective cyclooxygenase-2 inhibitor , on E-cadherin expression in gastric_carcinoma tissues -RSB- .
20416162	0	celecoxib	14,23	IFN-alpha	38,47	celecoxib	IFN-alpha	MESH:C105934	3439	Chemical	Gene	START_ENTITY|acl|combined combined|nmod|END_ENTITY	-LSB- Influence of celecoxib combined with IFN-alpha on proliferation , apoptosis , cell cycle and CD117 expression of K562 cells -RSB- .
19157634	0	celecoxib	12,21	Rad51	25,30	celecoxib	Rad51	MESH:C105934	5888	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	The role of celecoxib in Rad51 expression and cell survival affected by gefitinib in human non-small_cell_lung_cancer cells .
21397587	7	celecoxib	969,978	STAT3	1016,1021	celecoxib	BCL-2	MESH:C105934	596	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|phosphorylation phosphorylation|compound|END_ENTITY	We found that celecoxib inhibits IL-6-induced and persistent STAT3 phosphorylation and inhibits cell viability in human rhabdomyosarcoma cells .
23114124	0	celecoxib	28,37	VEGF	56,60	celecoxib	VEGF	MESH:C105934	7422	Chemical	Gene	START_ENTITY|nmod|expressions expressions|nmod|mRNA mRNA|amod|END_ENTITY	-LSB- Effects of COX-2 inhibitor celecoxib on expressions of VEGF , b-FGF and TGF-b mRNA in acute_leukemia cells -RSB- .
16134002	0	celecoxib	31,40	carbonic_anhydrase_II	72,93	celecoxib	carbonic anhydrase II	MESH:C105934	760	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	The cyclooxygenase-2 inhibitor celecoxib is a potent inhibitor of human carbonic_anhydrase_II .
10742298	0	celecoxib	44,53	cyclo-oxygenase-2	10,27	celecoxib	cyclo-oxygenase-2	MESH:C105934	29527(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Selective cyclo-oxygenase-2 inhibition with celecoxib elevates blood pressure and promotes leukocyte adherence .
14710108	0	celecoxib	123,132	cyclo-oxygenase-2	146,163	celecoxib	cyclo-oxygenase-2	MESH:C105934	100009248(Tax:9986)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Response of fetal prostanoids , nitric_oxide , and ductus arteriosus to the short - and long-term antenatal administration of celecoxib , a selective cyclo-oxygenase-2 inhibitor , in the pregnant rabbit .
16469112	0	celecoxib	179,188	cyclo-oxygenase-2	35,52	celecoxib	cyclo-oxygenase-2	MESH:C105934	5743	Chemical	Gene	-RSB-|compound|START_ENTITY comparison|nmod|-RSB- effect|dep|comparison effect|nmod|lumiracoxib lumiracoxib|amod|END_ENTITY	First-dose analgesic effect of the cyclo-oxygenase-2 selective inhibitor lumiracoxib in osteoarthritis_of_the_knee : a randomized , double-blind , placebo-controlled comparison with celecoxib -LSB- NCT00267215 -RSB- .
10560596	0	celecoxib	33,42	cyclooxygenase-2	46,62	celecoxib	cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	osteoarthritis|nmod|START_ENTITY Treatment|nmod|osteoarthritis Treatment|appos|inhibitor inhibitor|amod|END_ENTITY	Treatment of osteoarthritis with celecoxib , a cyclooxygenase-2 inhibitor : a randomized controlled trial .
10664917	0	celecoxib	11,20	cyclooxygenase-2	30,46	celecoxib	cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effects of celecoxib , a novel cyclooxygenase-2 inhibitor , on platelet function in healthy adults : a randomized , controlled trial .
10667579	0	celecoxib	72,81	cyclooxygenase-2	44,60	celecoxib	cyclooxygenase-2	MESH:C105934	29527(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Chemoprevention of colon_cancer by specific cyclooxygenase-2 inhibitor , celecoxib , administered during different stages of carcinogenesis .
10874062	0	celecoxib	14,23	cyclooxygenase-2	27,43	celecoxib	cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	The effect of celecoxib , a cyclooxygenase-2 inhibitor , in familial_adenomatous_polyposis .
11316141	0	celecoxib	48,57	cyclooxygenase-2	67,83	celecoxib	cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	gastroduodenal_ulcers|nmod|START_ENTITY incidence|nmod|gastroduodenal_ulcers incidence|appos|inhibitor inhibitor|amod|END_ENTITY	Reduced incidence of gastroduodenal_ulcers with celecoxib , a novel cyclooxygenase-2 inhibitor , compared to naproxen in patients with arthritis .
11317165	0	celecoxib	33,42	cyclooxygenase-2	52,68	celecoxib	cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Renal safety and tolerability of celecoxib , a novel cyclooxygenase-2 inhibitor .
11337938	0	celecoxib	23,32	cyclooxygenase-2	36,52	celecoxib	cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	In-vitro metabolism of celecoxib , a cyclooxygenase-2 inhibitor , by allelic variant forms of human liver microsomal cytochrome P450 2C9 : correlation with CYP2C9 genotype and in-vivo pharmacokinetics .
11408829	0	celecoxib	38,47	cyclooxygenase-2	10,26	celecoxib	cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	Effect|appos|START_ENTITY Effect|nmod|inhibitor inhibitor|amod|END_ENTITY	Effect of cyclooxygenase-2 inhibitor -LRB- celecoxib -RRB- on the infarcted heart in situ .
11429049	0	celecoxib	166,175	cyclooxygenase-2	138,154	celecoxib	cyclooxygenase-2	MESH:C105934	29527(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Suppression Suppression|nmod|inhibitor inhibitor|amod|END_ENTITY	Suppression of occurrence and advancement of beta-catenin-accumulated crypts , possible premalignant_lesions of colon_cancer , by selective cyclooxygenase-2 inhibitor , celecoxib .
11520213	0	celecoxib	24,33	cyclooxygenase-2	71,87	celecoxib	cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	analogues|amod|START_ENTITY analogues|nmod|inhibitors inhibitors|amod|END_ENTITY	Design and synthesis of celecoxib and rofecoxib analogues as selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors : replacement of sulfonamide and methylsulfonyl pharmacophores by an azido bioisostere .
11595712	0	celecoxib	68,77	cyclooxygenase-2	40,56	celecoxib	cyclooxygenase-2	MESH:C105934	19225(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Chronotherapy and chronotoxicity of the cyclooxygenase-2 inhibitor , celecoxib , in athymic mice bearing human breast_cancer xenografts .
11782374	0	celecoxib	151,160	cyclooxygenase-2	174,190	celecoxib	cyclooxygenase-2	MESH:C105934	29527(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Chemopreventive properties of a selective inducible nitric_oxide synthase inhibitor in colon carcinogenesis , administered alone or in combination with celecoxib , a selective cyclooxygenase-2 inhibitor .
11835924	0	celecoxib	61,70	cyclooxygenase-2	74,90	celecoxib	cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Comparison of thromboembolic_events in patients treated with celecoxib , a cyclooxygenase-2 specific inhibitor , versus ibuprofen or diclofenac .
11853703	0	celecoxib	51,60	cyclooxygenase-2	23,39	celecoxib	cyclooxygenase-2	MESH:C105934	19225(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Effects of a selective cyclooxygenase-2 inhibitor , celecoxib , on bone resorption and osteoclastogenesis in vitro .
11911965	0	celecoxib	96,105	cyclooxygenase-2	18,34	celecoxib	cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	effect|nmod|START_ENTITY Overexpression|dep|effect Overexpression|nmod|COX-2 COX-2|amod|END_ENTITY	Overexpression of cyclooxygenase-2 -LRB- COX-2 -RRB- in human primitive neuroectodermal_tumors : effect of celecoxib and rofecoxib .
12888902	0	celecoxib	75,84	cyclooxygenase-2	98,114	celecoxib	cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Apoptosis induction and enhancement of cytotoxicity of anticancer drugs by celecoxib , a selective cyclooxygenase-2 inhibitor , in human head_and_neck_carcinoma cell lines .
12960143	0	celecoxib	89,98	cyclooxygenase-2	111,127	celecoxib	cyclooxygenase-2	MESH:C105934	29527(Tax:10116)	Chemical	Gene	growth|nmod|START_ENTITY growth|dep|effects effects|nmod|regulation regulation|amod|END_ENTITY	Suppression of N-methyl-N-nitrosourea / testosterone-induced rat_prostate_cancer growth by celecoxib : effects on cyclooxygenase-2 , cell cycle regulation , and apoptosis mechanism -LRB- s -RRB- .
14604691	0	celecoxib	30,39	cyclooxygenase-2	63,79	celecoxib	cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	analogues|compound|START_ENTITY analogues|nmod|inhibitors inhibitors|amod|END_ENTITY	Design and synthesis of novel celecoxib analogues as selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors : replacement of the sulfonamide pharmacophore by a sulfonylazide bioisostere .
14693742	0	celecoxib	32,41	cyclooxygenase-2	4,20	celecoxib	cyclooxygenase-2	MESH:C105934	19225(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	The cyclooxygenase-2 inhibitor , celecoxib , prevents the development of mammary_tumors in Her-2 / neu mice .
14985462	0	celecoxib	68,77	cyclooxygenase-2	14,30	celecoxib	cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	action|nmod|START_ENTITY activities|nmod|action activities|amod|END_ENTITY	Modulation of cyclooxygenase-2 activities by the combined action of celecoxib and decosahexaenoic_acid : novel strategies for colon_cancer prevention and treatment .
15115339	0	celecoxib	61,70	cyclooxygenase-2	33,49	celecoxib	cyclooxygenase-2	MESH:C105934	29527(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Gastric effects of the selective cyclooxygenase-2 inhibitor , celecoxib , in the rat .
15150127	0	celecoxib	75,84	cyclooxygenase-2	47,63	celecoxib	cyclooxygenase-2	MESH:C105934	19225(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Combination of a poxvirus-based vaccine with a cyclooxygenase-2 inhibitor -LRB- celecoxib -RRB- elicits antitumor immunity and long-term survival in CEA.Tg / MIN mice .
15327804	0	celecoxib	127,136	cyclooxygenase-2	53,69	celecoxib	cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	comparison|nmod|START_ENTITY Treatment|dep|comparison Treatment|nmod|painful_temporomandibular_joints painful_temporomandibular_joints|nmod|inhibitor inhibitor|amod|END_ENTITY	Treatment of painful_temporomandibular_joints with a cyclooxygenase-2 inhibitor : a randomized placebo-controlled comparison of celecoxib to naproxen .
15458769	0	celecoxib	114,123	cyclooxygenase-2	22,38	celecoxib	cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	enhance|nsubj|START_ENTITY role|parataxis|enhance role|nmod|inhibitors inhibitors|amod|END_ENTITY	The potential role of cyclooxygenase-2 inhibitors in the treatment of experimentally-induced mammary_tumour : does celecoxib enhance the anti-tumour activity of doxorubicin ?
15659320	0	celecoxib	54,63	cyclooxygenase-2	25,41	celecoxib	cyclooxygenase-2	MESH:C105934	29527(Tax:10116)	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|inhibitors inhibitors|amod|END_ENTITY	The effects of selective cyclooxygenase-2 inhibitors , celecoxib and rofecoxib , on experimental colitis induced by acetic_acid in rats .
15862805	0	celecoxib	10,19	cyclooxygenase-2	23,39	celecoxib	cyclooxygenase-2	MESH:C105934	29527(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effect of celecoxib , a cyclooxygenase-2 inhibitor , on the pathophysiology of adjuvant_arthritis in rat .
16080279	0	celecoxib	27,36	cyclooxygenase-2	49,65	celecoxib	cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Pharmacological profile of celecoxib , a specific cyclooxygenase-2 inhibitor .
16166442	0	celecoxib	88,97	cyclooxygenase-2	10,26	celecoxib	cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	trial|nmod|START_ENTITY END_ENTITY|dep|trial	Targeting cyclooxygenase-2 in recurrent non-small_cell_lung_cancer : a phase II trial of celecoxib and docetaxel .
16168844	0	celecoxib	142,151	cyclooxygenase-2	114,130	celecoxib	cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	repair|xcomp|START_ENTITY repair|nmod|inhibitor inhibitor|amod|END_ENTITY	Inhibition of DNA repair as a mechanism of enhanced radioresponse of head_and_neck_carcinoma cells by a selective cyclooxygenase-2 inhibitor , celecoxib .
16430547	0	celecoxib	48,57	cyclooxygenase-2	61,77	celecoxib	cyclooxygenase-2	MESH:C105934	29527(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Analgesic effects of intrathecally administered celecoxib , a cyclooxygenase-2 inhibitor , in the tail flick test and the formalin test in rats .
16514081	0	celecoxib	43,52	cyclooxygenase-2	10,26	celecoxib	cyclooxygenase-2	MESH:C105934	19225(Tax:10090)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Selective cyclooxygenase-2 inhibition with celecoxib decreases angiotensin_II-induced abdominal_aortic_aneurysm formation in mice .
16709027	0	celecoxib	60,69	cyclooxygenase-2	92,108	celecoxib	cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	derivative|nmod|START_ENTITY derivative|acl:relcl|inhibit inhibit|xcomp|END_ENTITY	Antitumor properties of dimethyl-celecoxib , a derivative of celecoxib that does not inhibit cyclooxygenase-2 : implications for glioma therapy .
16806914	0	celecoxib	69,78	cyclooxygenase-2	106,122	celecoxib	cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	derivatives|nmod|START_ENTITY Design|nmod|derivatives Design|nmod|inhibitors inhibitors|amod|END_ENTITY	Design and synthesis of new water-soluble tetrazolide derivatives of celecoxib and rofecoxib as selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors .
16835711	0	celecoxib	19,28	cyclooxygenase-2	32,48	celecoxib	cyclooxygenase-2	MESH:C105934	29527(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|inhibitor inhibitor|amod|END_ENTITY	Chronic effects of celecoxib , a cyclooxygenase-2 inhibitor , cause enhanced alcohol-induced liver_steatosis in rats .
17037745	0	celecoxib	48,57	cyclooxygenase-2	75,91	celecoxib	cyclooxygenase-2	MESH:C105934	19225(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of nonsteroidal anti-inflammatory drug celecoxib on expression of cyclooxygenase-2 -LRB- COX-2 -RRB- in ovarian_carcinoma cell -RSB- .
17207548	0	celecoxib	43,52	cyclooxygenase-2	14,30	celecoxib	cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Inhibition of cyclooxygenase-2 activity by celecoxib does not lead to radiosensitization of human prostate_cancer cells in vitro .
17213003	0	celecoxib	158,167	cyclooxygenase-2	130,146	celecoxib	cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Cardiovascular events associated with the use of four nonselective NSAIDs -LRB- etodolac , nabumetone , ibuprofen , or naproxen -RRB- versus a cyclooxygenase-2 inhibitor -LRB- celecoxib -RRB- : a population-based analysis in Taiwanese adults .
17409801	0	celecoxib	107,116	cyclooxygenase-2	120,136	celecoxib	cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Phase II study of gefitinib , an epidermal growth factor receptor tyrosine kinase inhibitor -LRB- EGFR-TKI -RRB- , and celecoxib , a cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitor , in patients with platinum refractory non-small_cell_lung_cancer -LRB- NSCLC -RRB- .
17509125	0	celecoxib	10,19	cyclooxygenase-2	23,39	celecoxib	cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of celecoxib on cyclooxygenase-2 expression and possible variants in a patient with Barrett 's _ esophagus .
17646679	0	celecoxib	20,29	cyclooxygenase-2	58,74	celecoxib	cyclooxygenase-2	MESH:C105934	29527(Tax:10116)	Chemical	Gene	cytotoxicity|nmod|START_ENTITY independent|nsubj|cytotoxicity independent|amod|END_ENTITY	The cytotoxicity of celecoxib towards cardiac myocytes is cyclooxygenase-2 independent .
17908994	0	celecoxib	30,39	cyclooxygenase-2	84,100	celecoxib	cyclooxygenase-2	MESH:C105934	29527(Tax:10116)	Chemical	Gene	Exisulind|nmod|START_ENTITY Exisulind|nsubj|epidermal_growth_factor_receptor epidermal_growth_factor_receptor|appos|END_ENTITY	Exisulind in combination with celecoxib modulates epidermal_growth_factor_receptor , cyclooxygenase-2 , and cyclin_D1 against prostate carcinogenesis : in vivo evidence .
18166099	0	celecoxib	54,63	cyclooxygenase-2	26,42	celecoxib	cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	effect|appos|START_ENTITY effect|nmod|inhibitor inhibitor|amod|END_ENTITY	The effect of a selective cyclooxygenase-2 inhibitor -LRB- celecoxib -RRB- on chronic_periodontitis .
18281656	0	celecoxib	111,120	cyclooxygenase-2	47,63	celecoxib	cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	chemotherapy|amod|START_ENTITY factor|nmod|chemotherapy expression|acl:relcl|factor expression|amod|END_ENTITY	Eicosanoid modulation in advanced lung_cancer : cyclooxygenase-2 expression is a positive predictive factor for celecoxib + chemotherapy -- Cancer and Leukemia Group B Trial 30203 .
18758904	0	celecoxib	44,53	cyclooxygenase-2	57,73	celecoxib	cyclooxygenase-2	MESH:C105934	29527(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Micro-CT imaging analysis for the effect of celecoxib , a cyclooxygenase-2 inhibitor , on inflammatory bone_destruction in adjuvant arthritis rats .
19356723	0	celecoxib	23,32	cyclooxygenase-2	117,133	celecoxib	cyclooxygenase-2	MESH:C105934	29527(Tax:10116)	Chemical	Gene	treatment|nmod|START_ENTITY reverses|nsubj|treatment reverses|dobj|behavior behavior|acl|reducing reducing|dobj|expression expression|amod|END_ENTITY	Chronic treatment with celecoxib reverses chronic unpredictable stress-induced depressive-like behavior via reducing cyclooxygenase-2 expression in rat brain .
19622294	0	celecoxib	38,47	cyclooxygenase-2	61,77	celecoxib	cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	-LSB- Short-term preoperative treatment of celecoxib , a selective cyclooxygenase-2 inhibitor , on E-cadherin expression in gastric_carcinoma tissues -RSB- .
20410610	0	celecoxib	10,19	cyclooxygenase-2	33,49	celecoxib	cyclooxygenase-2	MESH:C105934	29527(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effect of celecoxib , a selective cyclooxygenase-2 inhibitor on carbon_tetrachloride intoxication in rats .
20937780	0	celecoxib	48,57	cyclooxygenase-2	61,77	celecoxib	cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Inhibition of bacterial multidrug resistance by celecoxib , a cyclooxygenase-2 inhibitor .
21413548	0	celecoxib	31,40	cyclooxygenase-2	4,20	celecoxib	cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	START_ENTITY|nsubj|inhibitor inhibitor|amod|END_ENTITY	The cyclooxygenase-2 inhibitor celecoxib and alveolar_osteitis .
21559762	0	celecoxib	21,30	cyclooxygenase-2	66,82	celecoxib	cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	START_ENTITY|nmod|lung_carcinoma lung_carcinoma|nmod|regulation regulation|nmod|cytosolic cytosolic|amod|END_ENTITY	Inhibitory effect of celecoxib in lung_carcinoma by regulation of cyclooxygenase-2 / cytosolic phospholipase A and peroxisome_proliferator-activated_receptor_gamma .
22104269	0	celecoxib	72,81	cyclooxygenase-2	94,110	celecoxib	cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Systematic analyses of genes associated with radiosensitizing effect by celecoxib , a specific cyclooxygenase-2 inhibitor .
22170412	0	celecoxib	134,143	cyclooxygenase-2	40,56	celecoxib	cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	comparing|dobj|START_ENTITY trial|acl|comparing induced|dep|trial induced|nmod|inhibitors inhibitors|amod|END_ENTITY	Small_bowel_injury induced by selective cyclooxygenase-2 inhibitors : a prospective , double-blind , randomized clinical trial comparing celecoxib and meloxicam .
22648851	0	celecoxib	74,83	cyclooxygenase-2	97,113	celecoxib	cyclooxygenase-2	MESH:C105934	29527(Tax:10116)	Chemical	Gene	-LSB-|nmod|START_ENTITY -RSB-|advcl|-LSB- -RSB-|nsubj|inhibitor inhibitor|amod|END_ENTITY	-LSB- An experimental study on chemoprevention of esophageal_adenocarcinoma by celecoxib , a selective cyclooxygenase-2 inhibitor -RSB- .
22672748	0	celecoxib	97,106	cyclooxygenase-2	69,85	celecoxib	cyclooxygenase-2	MESH:C105934	19225(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Mitigation and treatment of radiation-induced thoracic_injury with a cyclooxygenase-2 inhibitor , celecoxib .
22751903	0	celecoxib	72,81	cyclooxygenase-2	41,57	celecoxib	cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Antitumor and anti-metastatic effects of cyclooxygenase-2 inhibition by celecoxib on human colorectal_carcinoma xenografts in nude mouse rectum .
23249419	0	celecoxib	64,73	cyclooxygenase-2	36,52	celecoxib	cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Antitumor activity of the selective cyclooxygenase-2 inhibitor , celecoxib , on breast_cancer in Vitro and in Vivo .
23347845	0	celecoxib	45,54	cyclooxygenase-2	12,28	celecoxib	cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Increase of cyclooxygenase-2 inhibition with celecoxib combined with 5-FU enhances tumor cell apoptosis and antitumor efficacy in a subcutaneous implantation_tumor model of human colon_cancer .
23826496	0	celecoxib	14,23	cyclooxygenase-2	27,43	celecoxib	cyclooxygenase-2	MESH:C105934	100135607(Tax:10141)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	The effect of celecoxib , a cyclooxygenase-2 inhibitor on noise - induced hearing_loss .
23960285	0	celecoxib	51,60	cyclooxygenase-2	23,39	celecoxib	cyclooxygenase-2	MESH:C105934	29527(Tax:10116)	Chemical	Gene	Effects|appos|START_ENTITY Effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Effects of a selective cyclooxygenase-2 inhibitor -LRB- celecoxib -RRB- on fracture healing in rats .
24346019	0	celecoxib	22,31	cyclooxygenase-2	45,61	celecoxib	cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Antitumor activity of celecoxib , a selective cyclooxygenase-2 inhibitor , in medullary_thyroid_carcinoma .
25667511	0	celecoxib	78,87	cyclooxygenase-2	103,119	celecoxib	cyclooxygenase-2	MESH:C105934	5743	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Vitamin_d inhibits ovarian_cancer cell line proliferation in combination with celecoxib and suppresses cyclooxygenase-2 expression .
9458081	0	celecoxib	28,37	cyclooxygenase-2	50,66	celecoxib	cyclooxygenase-2	MESH:C105934	29527(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Chemopreventive activity of celecoxib , a specific cyclooxygenase-2 inhibitor , against colon_carcinogenesis .
10497139	0	celecoxib	86,95	cyclooxygenase_2	58,74	celecoxib	cyclooxygenase 2	MESH:C105934	442942(Tax:9615)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Evidence for polymorphism in the canine metabolism of the cyclooxygenase_2 inhibitor , celecoxib .
10786667	0	celecoxib	44,53	cyclooxygenase_2	57,73	celecoxib	cyclooxygenase 2	MESH:C105934	29527(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Chemoprevention of breast_cancer in rats by celecoxib , a cyclooxygenase_2 inhibitor .
12010890	0	celecoxib	56,65	cyclooxygenase_2	79,95	celecoxib	cyclooxygenase 2	MESH:C105934	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	A randomised , double blind , placebo controlled study of celecoxib , a selective cyclooxygenase_2 inhibitor , on duodenal_polyposis in familial_adenomatous_polyposis .
16385545	0	celecoxib	147,156	cyclooxygenase_2	30,46	celecoxib	cyclooxygenase 2	MESH:C105934	5743	Chemical	Gene	pronounced|advcl|START_ENTITY pronounced|dobj|inhibition inhibition|nmod|END_ENTITY	More pronounced inhibition of cyclooxygenase_2 , increase in blood pressure , and reduction of heart rate by treatment with diclofenac compared with celecoxib and rofecoxib .
17178263	0	celecoxib	78,87	cyclooxygenase_2	4,20	celecoxib	cyclooxygenase 2	MESH:C105934	5743	Chemical	Gene	effects|nmod|START_ENTITY modulate|dobj|effects modulate|nsubj|C C|amod|END_ENTITY	The cyclooxygenase_2 genetic variant -765 G > C does not modulate the effects of celecoxib on prostaglandin_E2 production .
23681187	0	celecoxib	119,128	cyclooxygenase_2	55,71	celecoxib	cyclooxygenase 2	MESH:C105934	19225(Tax:10090)	Chemical	Gene	stimulates|nmod|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Telomerase_reverse_transcriptase inhibition stimulates cyclooxygenase_2 expression in cancer cells and synergizes with celecoxib to exert anti-cancer effects .
10773015	0	celecoxib	97,106	cytochrome_P450_2C9	37,56	celecoxib	cytochrome P450 2C9	MESH:C105934	1559	Chemical	Gene	metabolism|nmod|START_ENTITY role|nmod|metabolism role|nmod|END_ENTITY	Major role of human liver microsomal cytochrome_P450_2C9 -LRB- CYP2C9 -RRB- in the oxidative metabolism of celecoxib , a novel cyclooxygenase-II inhibitor .
12392591	0	celecoxib	13,22	cytochrome_P450_2C9	38,57	celecoxib	cytochrome P450 2C9	MESH:C105934	1559	Chemical	Gene	Oxidation|nmod|START_ENTITY Oxidation|nmod|END_ENTITY	Oxidation of celecoxib by polymorphic cytochrome_P450_2C9 and alcohol_dehydrogenase .
23285691	0	celecoxib	10,19	e-cadherin	77,87	celecoxib	e-cadherin	MESH:C105934	999	Chemical	Gene	START_ENTITY|nmod|concentrations concentrations|amod|END_ENTITY	Impact of celecoxib on soluble intercellular_adhesion_molecule-1 and soluble e-cadherin concentrations in human colon_cancer cell line cultures exposed to phytic_acid and TNF-alpha .
23285691	0	celecoxib	10,19	intercellular_adhesion_molecule-1	31,64	celecoxib	intercellular adhesion molecule-1	MESH:C105934	3383	Chemical	Gene	START_ENTITY|nmod|concentrations concentrations|amod|END_ENTITY	Impact of celecoxib on soluble intercellular_adhesion_molecule-1 and soluble e-cadherin concentrations in human colon_cancer cell line cultures exposed to phytic_acid and TNF-alpha .
18303430	0	celecoxib	30,39	matrix_metalloproteinase-9	126,152	celecoxib	matrix metalloproteinase-9	MESH:C105934	4318	Chemical	Gene	response|nmod|START_ENTITY associated|nsubjpass|response associated|nmod|END_ENTITY	Tumor response to combination celecoxib and erlotinib therapy in non-small_cell_lung_cancer is associated with a low baseline matrix_metalloproteinase-9 and a decline in serum-soluble E-cadherin .
19327236	0	celecoxib	11,20	osteoprotegerin	42,57	celecoxib	osteoprotegerin	MESH:C105934	4982	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effects of celecoxib on the expression of osteoprotegerin , energy metabolism and cell viability in cultured human osteoblastic cells .
15483193	0	celecoxib	60,69	sulfotransferase_2A1	27,47	celecoxib	sulfotransferase 2A1	MESH:C105934	6822	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Heterotropic modulation of sulfotransferase_2A1 activity by celecoxib : product ratio switching of ethynylestradiol sulfation .
18922176	0	celecoxib	32,41	uPA	0,3	celecoxib	uPA	MESH:C105934	5328	Chemical	Gene	upregulated|nmod|START_ENTITY upregulated|nsubjpass|END_ENTITY	uPA is upregulated by high dose celecoxib in women at increased risk of developing breast_cancer .
21696999	0	celecoxib	102,111	vascular_endothelial_growth_factor	17,51	celecoxib	vascular endothelial growth factor	MESH:C105934	7422	Chemical	Gene	levels|nmod|START_ENTITY levels|nmod|END_ENTITY	Plasma levels of vascular_endothelial_growth_factor during and after radiotherapy in combination with celecoxib in patients with advanced head_and_neck_cancer .
22951014	0	celecoxib	79,88	vascular_endothelial_growth_factor	26,60	celecoxib	vascular endothelial growth factor	MESH:C105934	7422	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Predictive role of plasma vascular_endothelial_growth_factor for the effect of celecoxib in advanced non-small_cell_lung_cancer treated with chemotherapy .
24649093	0	celecoxib	10,19	vascular_endothelial_growth_factor	66,100	celecoxib	vascular endothelial growth factor	MESH:C105934	7422	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|chemotherapy chemotherapy|nmod|levels levels|nmod|END_ENTITY	Effect of celecoxib plus standard chemotherapy on serum levels of vascular_endothelial_growth_factor and cyclooxygenase-2 in patients with gastric_cancer .
17909747	0	cellobiose	50,60	IL1403	113,119	cellobiose	IL1403	MESH:D002475	3173391(Tax:283942)	Chemical	Gene	characterisation|nmod|START_ENTITY transport|nsubj|characterisation transport|nmod|END_ENTITY	Identification and functional characterisation of cellobiose and lactose transport systems in Lactococcus_lactis IL1403 .
25239037	0	cellobiose	30,40	IL1403	86,92	cellobiose	IL1403	MESH:D002475	3173391(Tax:283942)	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|nmod|END_ENTITY	ClaR-a novel key regulator of cellobiose and lactose metabolism in Lactococcus_lactis IL1403 .
15842197	0	celostatin	234,244	cysteine-proteinase_inhibitor	203,232	celostatin	cysteine-proteinase inhibitor	null	1470	Chemical	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Cystatins may confer viral resistance in plants by inhibition of a virus-induced cell death phenomenon in which cysteine proteinases are active : cloning and molecular characterization of a cDNA encoding cysteine-proteinase_inhibitor -LRB- celostatin -RRB- from Celosia cristata -LRB- crested cock 's comb -RRB- .
17229448	0	centaurein	14,24	interferon-gamma	28,44	centaurein	interferon-gamma	MESH:C111521	15978(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|amod|END_ENTITY	The effect of centaurein on interferon-gamma expression and Listeria_infection in mice .
2548832	0	centrophenoxine	11,26	cholinephosphotransferase	30,55	centrophenoxine	cholinephosphotransferase	MESH:D002504	100718704	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|amod|END_ENTITY	Effects of centrophenoxine on cholinephosphotransferase activity in maternal and fetal guinea_pig lung .
3137089	0	centrophenoxine	11,26	monoamine_oxidase	60,77	centrophenoxine	monoamine oxidase	MESH:D002504	29253(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	-LSB- Effect of centrophenoxine , piracetam and aniracetam on the monoamine_oxidase activity in different brain structures of rats -RSB- .
11160109	0	cephalosporin	151,164	C10	204,207	cephalosporin	C10	CHEBI:23066	3226	Chemical	Gene	biosynthesis|compound|START_ENTITY biosynthesis|nmod|END_ENTITY	Targeted inactivation of the mecB gene , encoding cystathionine-gamma-lyase , shows that the reverse transsulfuration pathway is required for high-level cephalosporin biosynthesis in Acremonium chrysogenum C10 but not for methionine induction of the cephalosporin genes .
8585742	0	cephalosporin	68,81	S-1090	49,55	cephalosporin	S-1090	CHEBI:23066	1077488(Tax:198215)	Chemical	Gene	START_ENTITY|nmod|activities activities|nmod|END_ENTITY	In vitro and in vivo antibacterial activities of S-1090 , a new oral cephalosporin .
1510428	0	cephalosporin	62,75	SCE-2787	35,43	cephalosporin	SCE-2787	CHEBI:23066	5805487(Tax:448385)	Chemical	Gene	START_ENTITY|nmod|activities activities|nmod|END_ENTITY	In vitro and in vivo activities of SCE-2787 , a new parenteral cephalosporin with a broad antibacterial spectrum .
2002452	0	cephalosporins	53,67	C-7	95,98	cephalosporins	C-7	MESH:D002511	730	Chemical	Gene	Synthesis|nmod|START_ENTITY Synthesis|nmod|END_ENTITY	Synthesis and structure-activity relationship of new cephalosporins with amino heterocycles at C-7 .
21765632	0	cepharanthine_hydrochloride	120,147	P-glycoprotein	84,98	cepharanthine hydrochloride	P-glycoprotein	null	67078(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|amod|END_ENTITY	Using rhodamine_123 accumulation in CD8 cells as a surrogate indicator to study the P-glycoprotein modulating effect of cepharanthine_hydrochloride in vivo .
26253821	0	ceramide	14,22	ASMase	65,71	ceramide	ASMase	CHEBI:17761	20597(Tax:10090)	Chemical	Gene	generation|amod|START_ENTITY Regulation|nmod|generation apoptosis|nsubj|Regulation apoptosis|nmod|END_ENTITY	Regulation of ceramide generation during macrophage apoptosis by ASMase and de novo synthesis .
16601923	0	ceramide	92,100	CERT	37,41	ceramide	CERT	CHEBI:17761	10087	Chemical	Gene	trafficking|nmod|START_ENTITY END_ENTITY|nmod|trafficking	Discovery of the molecular machinery CERT for endoplasmic reticulum-to-Golgi trafficking of ceramide .
16895911	0	ceramide	25,33	CERT	149,153	ceramide	CERT	CHEBI:17761	10087	Chemical	Gene	trafficking|nmod|START_ENTITY requires|nsubj|trafficking requires|dobj|motif motif|nmod|END_ENTITY	Efficient trafficking of ceramide from the endoplasmic reticulum to the Golgi apparatus requires a VAMP-associated protein-interacting FFAT motif of CERT .
17314061	0	ceramide	38,46	CERT	0,4	ceramide	CERT	CHEBI:17761	10087	Chemical	Gene	trafficking|nmod|START_ENTITY trafficking|compound|END_ENTITY	CERT and intracellular trafficking of ceramide .
17442665	0	ceramide	30,38	CERT	131,135	ceramide	CERT	CHEBI:17761	10087	Chemical	Gene	trafficking|nmod|START_ENTITY regulated|nsubjpass|trafficking regulated|nmod|cooperativity cooperativity|nmod|END_ENTITY	Interorganelle trafficking of ceramide is regulated by phosphorylation-dependent cooperativity between the PH and START domains of CERT .
18165232	0	ceramide	110,118	CERT	137,141	ceramide	CERT	CHEBI:17761	10087	Chemical	Gene	protein|amod|START_ENTITY END_ENTITY|nsubj|protein	Protein phosphatase 2Cepsilon is an endoplasmic reticulum integral membrane protein that dephosphorylates the ceramide transport protein CERT to enhance its association with organelle membranes .
18184806	0	ceramide	100,108	CERT	51,55	ceramide	CERT	CHEBI:17761	10087	Chemical	Gene	trafficking|nmod|START_ENTITY responsible|nmod|trafficking basis|amod|responsible basis|nmod|recognition recognition|nmod|END_ENTITY	Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide .
20036255	0	ceramide	99,107	CERT	26,30	ceramide	CERT	CHEBI:17761	10087	Chemical	Gene	transfer|amod|START_ENTITY mechanism|nmod|transfer provide|nmod|mechanism provide|nsubj|structures structures|nmod|domain domain|compound|END_ENTITY	Crystal structures of the CERT START domain with inhibitors provide insights into the mechanism of ceramide transfer .
20875392	0	ceramide	18,26	CERT	50,54	ceramide	CERT	CHEBI:17761	10087	Chemical	Gene	transport|compound|START_ENTITY transport|acl|catalyzed catalyzed|nmod|END_ENTITY	The intermembrane ceramide transport catalyzed by CERT is sensitive to the lipid environment .
22869376	0	ceramide	84,92	CERT	114,118	ceramide	CERT	CHEBI:17761	10087	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Structural basis for the Golgi association by the pleckstrin homology domain of the ceramide trafficking protein -LRB- CERT -RRB- .
24569996	0	ceramide	160,168	CERT	52,56	ceramide	CERT	CHEBI:17761	10087	Chemical	Gene	trafficking|nmod|START_ENTITY protein|nmod|trafficking END_ENTITY|nmod|protein	Phosphoregulation of the ceramide transport protein CERT at serine 315 in the interaction with VAMP-associated protein -LRB- VAP -RRB- for inter-organelle trafficking of ceramide in mammalian cells .
24569996	0	ceramide	25,33	CERT	52,56	ceramide	CERT	CHEBI:17761	10087	Chemical	Gene	protein|amod|START_ENTITY Phosphoregulation|nmod|protein END_ENTITY|nsubj|Phosphoregulation	Phosphoregulation of the ceramide transport protein CERT at serine 315 in the interaction with VAMP-associated protein -LRB- VAP -RRB- for inter-organelle trafficking of ceramide in mammalian cells .
10508159	0	ceramide	54,62	Cathepsin_D	0,11	ceramide	Cathepsin D	CHEBI:17761	1509	Chemical	Gene	targeted|nmod|START_ENTITY targeted|nsubj|END_ENTITY	Cathepsin_D targeted by acid_sphingomyelinase-derived ceramide .
12034359	0	ceramide	26,34	ERK	8,11	ceramide	ERK	CHEBI:17761	5594	Chemical	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Delayed ERK activation by ceramide reduces melanin synthesis in human melanocytes .
12684378	0	ceramide	87,95	Elo3p	109,114	ceramide	Elo3p	CHEBI:17761	851087(Tax:4932)	Chemical	Gene	synthesis|amod|START_ENTITY synthesis|nmod|END_ENTITY	Ceramide/long-chain base phosphate rheostat in Saccharomyces_cerevisiae : regulation of ceramide synthesis by Elo3p and Cka2p .
18424781	0	ceramide	61,69	Goodpasture_antigen-binding_protein	0,35	ceramide	Goodpasture antigen-binding protein	CHEBI:17761	796455(Tax:7955)	Chemical	Gene	protein|amod|START_ENTITY END_ENTITY|appos|protein	Goodpasture_antigen-binding_protein and its spliced variant , ceramide transfer protein , have different functions in the modulation of apoptosis during zebrafish development .
21483866	0	ceramide	32,40	HRK	51,54	ceramide	HRK	CHEBI:17761	8739	Chemical	Gene	START_ENTITY|dobj|expression expression|amod|END_ENTITY	Mitochondrial dysfunction links ceramide activated HRK expression and cell death .
19372430	0	ceramide	46,54	HYL-2	40,45	ceramide	HYL-2	CHEBI:17761	180743(Tax:6239)	Chemical	Gene	synthase|compound|START_ENTITY synthase|compound|END_ENTITY	Protection of C. _ elegans from anoxia by HYL-2 ceramide synthase .
8751967	0	ceramide	230,238	IFN-gamma	261,270	ceramide	IFN-gamma	CHEBI:17761	3458	Chemical	Gene	START_ENTITY|nmod|action action|nmod|END_ENTITY	Inhibitors of sphingolipid synthesis modulate interferon -LRB- IFN -RRB- - gamma-induced intercellular adhesion molecule -LRB- ICAM -RRB- -1 and human leukocyte_antigen _ -LRB- HLA -RRB- - DR expression on cultured normal human keratinocytes : possible involvement of ceramide in biologic action of IFN-gamma .
11161461	0	ceramide	76,84	IL-1_beta	20,29	ceramide	IL-1 beta	CHEBI:17761	3553	Chemical	Gene	involves|dobj|START_ENTITY involves|nsubj|action action|appos|END_ENTITY	Interleukin_1_beta -LRB- IL-1_beta -RRB- action in porcine thyroid cells involves the ceramide signalling pathway .
9227535	0	ceramide	15,23	IL-1_beta	48,57	ceramide	IL-1 beta	CHEBI:17761	24494(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|effect effect|nmod|END_ENTITY	Involvement of ceramide in inhibitory effect of IL-1_beta on L-type Ca2 + current in adult rat ventricular myocytes .
10899932	0	ceramide	75,83	Interleukin-10	0,14	ceramide	Interleukin-10	CHEBI:17761	25325(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY inhibit|dobj|production inhibit|nsubj|END_ENTITY	Interleukin-10 and interleukin-13 inhibit proinflammatory cytokine-induced ceramide production through the activation of phosphatidylinositol 3-kinase .
19891536	0	ceramide	25,33	JNK	75,78	ceramide	JNK	CHEBI:17761	116554(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY stimulate|nsubj|production stimulate|dobj|END_ENTITY	Sphingomyelinase-induced ceramide production stimulate calcium-independent JNK and PP2A activation following cerebral_ischemia .
25168245	0	ceramide	15,23	JNK	102,105	ceramide	JNK	CHEBI:17761	5599	Chemical	Gene	START_ENTITY|nmod|signaling signaling|compound|END_ENTITY	Stress-induced ceramide generation and apoptosis via the phosphorylation and activation of nSMase1 by JNK signaling .
23123064	0	ceramide	112,120	LMIR3	13,18	ceramide	LMIR3	CHEBI:17761	246746(Tax:10090)	Chemical	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	The receptor LMIR3 negatively regulates mast cell activation and allergic responses by binding to extracellular ceramide .
12493772	0	ceramide	28,36	Lcb4p	0,5	ceramide	Lcb4p	CHEBI:17761	854342(Tax:4932)	Chemical	Gene	synthesis|amod|START_ENTITY regulator|nmod|synthesis regulator|nsubj|END_ENTITY	Lcb4p is a key regulator of ceramide synthesis from exogenous long chain sphingoid base in Saccharomyces_cerevisiae .
14995068	0	ceramide	28,36	NF-kappaB	72,81	ceramide	NF-kappaB	CHEBI:17761	4790	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Differential involvement of ceramide in TNFalpha-mediated activation of NF-kappaB in primary human keratinocytes and HaCaT keratinocytes .
25842287	0	ceramide	77,85	ORMDL3	45,51	ceramide	ORMDL3	CHEBI:17761	66612(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY homeostasis|appos|END_ENTITY	Aberrant ORM -LRB- yeast -RRB- - like protein isoform 3 -LRB- ORMDL3 -RRB- expression dysregulates ceramide homeostasis in cells and ceramide exacerbates allergic_asthma in mice .
10737718	0	ceramide	61,69	P-glycoprotein	108,122	ceramide	P-glycoprotein	CHEBI:17761	5243	Chemical	Gene	formation|compound|START_ENTITY activates|dobj|formation activates|nmod|independent independent|nmod|END_ENTITY	SDZ PSC_833 the drug resistance modulator activates cellular ceramide formation by a pathway independent of P-glycoprotein .
12130682	0	ceramide	13,21	P-glycoprotein	36,50	ceramide	P-glycoprotein	CHEBI:17761	5243	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|nmod|END_ENTITY	Influence of ceramide metabolism on P-glycoprotein function in immature acute_myeloid_leukemia KG1a cells .
21042729	0	ceramide	65,73	P-glycoprotein	14,28	ceramide	P-glycoprotein	CHEBI:17761	5243	Chemical	Gene	confers|advcl|START_ENTITY confers|nsubj|Expression Expression|nmod|END_ENTITY	Expression of P-glycoprotein in HeLa cells confers resistance to ceramide cytotoxicity .
21396934	0	ceramide	73,81	P-glycoprotein	0,14	ceramide	P-glycoprotein	CHEBI:17761	5243	Chemical	Gene	confer|nmod|START_ENTITY confer|nsubj|antagonists antagonists|amod|END_ENTITY	P-glycoprotein antagonists confer synergistic sensitivity to short-chain ceramide in human multidrug-resistant cancer cells .
17467659	0	ceramide	36,44	Sphingomyelin_synthase_1	0,24	ceramide	Sphingomyelin synthase 1	CHEBI:17761	259230	Chemical	Gene	START_ENTITY|nsubj|suppresses suppresses|amod|END_ENTITY	Sphingomyelin_synthase_1 suppresses ceramide production and apoptosis post-photodamage .
9079627	0	ceramide	18,26	TAK1	0,4	ceramide	TAK1	CHEBI:17761	6885	Chemical	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	TAK1 mediates the ceramide signaling to stress-activated protein kinase/c-Jun N-terminal kinase .
10070113	0	ceramide	20,28	TNF-alpha	0,9	ceramide	TNF-alpha	CHEBI:17761	24835(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|increases increases|amod|END_ENTITY	TNF-alpha increases ceramide without inducing apoptosis in alveolar type II epithelial cells .
10411298	0	ceramide	78,86	TNF_alpha	22,31	ceramide	TNF alpha	CHEBI:17761	21926(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY effects|dep|role effects|nmod|END_ENTITY	Inhibitory effects of TNF_alpha on mouse tumor Leydig cells : possible role of ceramide in the mechanism of action .
7487982	0	ceramide	113,121	Tumor_necrosis_factor_alpha	0,27	ceramide	Tumor necrosis factor alpha	CHEBI:17761	7124	Chemical	Gene	increases|nmod|START_ENTITY increases|nsubj|END_ENTITY	Tumor_necrosis_factor_alpha increases tyrosine phosphorylation of a 23-kDa nuclear protein in U937 cells through ceramide signaling pathway .
25395359	0	ceramide	63,71	aPKC	73,77	ceramide	aPKC	CHEBI:17761	18762(Tax:10090)	Chemical	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Hepatic insulin resistance in ob/ob mice involves increases in ceramide , aPKC activity , and selective impairment of Akt-dependent FoxO1 phosphorylation .
11112337	0	ceramide	52,60	cyclin-dependent_kinase_2	14,39	ceramide	cyclin-dependent kinase 2	CHEBI:17761	1017	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|activity activity|amod|END_ENTITY	Regulation of cyclin-dependent_kinase_2 activity by ceramide .
9478967	0	ceramide	86,94	fibroblast_collagenase	15,37	ceramide	fibroblast collagenase	CHEBI:17761	4312	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Enhancement of fibroblast_collagenase -LRB- matrix_metalloproteinase-1 -RRB- gene expression by ceramide is mediated by extracellular signal-regulated and stress-activated protein kinase pathways .
10400316	0	ceramide	10,18	interleukin-6	22,35	ceramide	interleukin-6	CHEBI:17761	16193(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|synthesis synthesis|amod|END_ENTITY	Effect of ceramide on interleukin-6 synthesis in osteoblast-like cells .
19279008	0	ceramide	101,109	interleukin-6	68,81	ceramide	interleukin-6	CHEBI:17761	3569	Chemical	Gene	role|nmod|START_ENTITY induction|dep|role induction|nmod|END_ENTITY	Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6 : possible role for ceramide as an anti-inflammatory lipid .
12147222	0	ceramide	166,174	mCD54	195,200	ceramide	mCD54	CHEBI:17761	15894(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|the the|nmod|END_ENTITY	Modulation of the expression of membrane-bound CD54 -LRB- mCD54 -RRB- and soluble form of CD54 -LRB- sCD54 -RRB- in endothelial cells by glucosyl transferase inhibitor : possible role of ceramide for the shedding of mCD54 .
11129654	0	ceramide	77,85	neutral_sphingomyelinase	101,125	ceramide	neutral sphingomyelinase	CHEBI:17761	6610	Chemical	Gene	generation|amod|START_ENTITY generation|nmod|END_ENTITY	Streptolysin_O-permeabilized granulocytes shed L-selectin concomitantly with ceramide generation via neutral_sphingomyelinase .
11162568	0	ceramide	71,79	neutral_sphingomyelinase	30,54	ceramide	neutral sphingomyelinase	CHEBI:17761	6610	Chemical	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	Effect of overexpression of a neutral_sphingomyelinase on CD95-induced ceramide production and apoptosis .
12473648	0	ceramide	80,88	neutral_sphingomyelinase	31,55	ceramide	neutral sphingomyelinase	CHEBI:17761	6610	Chemical	Gene	generate|dobj|START_ENTITY caveolae|xcomp|generate caveolae|nsubj|mechanoactivation mechanoactivation|nmod|END_ENTITY	Transient mechanoactivation of neutral_sphingomyelinase in caveolae to generate ceramide .
14720208	0	ceramide	46,54	neutral_sphingomyelinase	12,36	ceramide	neutral sphingomyelinase	CHEBI:17761	83537(Tax:10116)	Chemical	Gene	produced|dobj|START_ENTITY produced|nsubj|role role|nmod|END_ENTITY	The role of neutral_sphingomyelinase produced ceramide in lipopolysaccharide-mediated expression of inducible_nitric_oxide_synthase .
17685585	0	ceramide	130,138	neutral_sphingomyelinase	186,210	ceramide	neutral sphingomyelinase	CHEBI:17761	6610	Chemical	Gene	generation|amod|START_ENTITY promoting|dobj|generation promoting|nmod|END_ENTITY	The group VIA calcium-independent phospholipase_A2 participates in ER stress-induced INS-1 insulinoma cell apoptosis by promoting ceramide generation via hydrolysis of sphingomyelins by neutral_sphingomyelinase .
18299447	0	ceramide	67,75	neutral_sphingomyelinase	17,41	ceramide	neutral sphingomyelinase	CHEBI:17761	6610	Chemical	Gene	pathway|amod|START_ENTITY implicate|dobj|pathway implicate|nsubj|Mutations Mutations|nmod|SMPD3 SMPD3|amod|END_ENTITY	Mutations in the neutral_sphingomyelinase gene SMPD3 implicate the ceramide pathway in human leukemias .
23353700	0	ceramide	42,50	p53	99,102	ceramide	p53	CHEBI:17761	7157	Chemical	Gene	independent|amod|START_ENTITY independent|nmod|END_ENTITY	Tamoxifen magnifies therapeutic impact of ceramide in human colorectal_cancer cells independent of p53 .
15563986	0	ceramide	118,126	peroxisome_proliferator-activated_receptor_gamma	35,83	ceramide	peroxisome proliferator-activated receptor gamma	CHEBI:17761	5468	Chemical	Gene	production|nmod|START_ENTITY END_ENTITY|nmod|production	TNFalpha reduces the expression of peroxisome_proliferator-activated_receptor_gamma -LRB- PPARgamma -RRB- via the production of ceramide and activation of atypical PKC .
11897496	0	ceramide	61,69	phosphatase-2A	86,100	ceramide	phosphatase-2A	CHEBI:17761	5524	Chemical	Gene	induced|nmod|START_ENTITY induced|nmod|END_ENTITY	Lithium blocks the PKB and GSK3 dephosphorylation induced by ceramide through protein phosphatase-2A .
11107162	0	ceramide	97,105	plasminogen_activator_inhibitor-1	11,44	ceramide	plasminogen activator inhibitor-1	CHEBI:17761	5054	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|Release Release|nmod|END_ENTITY	Release of plasminogen_activator_inhibitor-1 from human astrocytes is regulated by intracellular ceramide .
12479368	0	ceramide	17,25	serine_palmitoyltransferase	59,86	ceramide	serine palmitoyltransferase	CHEBI:17761	189	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Enhanced de novo ceramide generation through activation of serine_palmitoyltransferase by the P-glycoprotein antagonist SDZ_PSC_833 in breast_cancer cells .
18996115	0	ceramide	29,37	thioredoxin	14,25	ceramide	thioredoxin	CHEBI:17761	7295	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of thioredoxin by ceramide in retinal pigment epithelial cells .
18086664	0	ceramide_1-phosphate	26,46	ceramide_kinase	59,74	ceramide 1-phosphate	ceramide kinase	MESH:C065576	223753(Tax:10090)	Chemical	Gene	START_ENTITY|acl|produced produced|nmod|END_ENTITY	Regulation and traffic of ceramide_1-phosphate produced by ceramide_kinase : comparative analysis to glucosylceramide and sphingomyelin .
17714445	0	ceramides	42,51	CWH43	0,5	ceramides	CWH43	MESH:D002518	850376(Tax:4932)	Chemical	Gene	introduction|nmod|START_ENTITY required|nmod|introduction required|nsubjpass|END_ENTITY	CWH43 is required for the introduction of ceramides into GPI anchors in Saccharomyces_cerevisiae .
17761529	0	ceramides	99,108	CWH43	25,30	ceramides	CWH43	MESH:D002518	850376(Tax:4932)	Chemical	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	Saccharomyces_cerevisiae CWH43 is involved in the remodeling of the lipid moiety of GPI anchors to ceramides .
21592087	0	ceramides	46,55	Ceramide_synthase_4	0,19	ceramides	Ceramide synthase 4	MESH:D002518	79603	Chemical	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	Ceramide_synthase_4 and de novo production of ceramides with specific N-acyl chain lengths are involved in glucolipotoxicity-induced apoptosis of INS-1 b-cells .
20206917	0	ceramides	36,45	Gb3	23,26	ceramides	Gb3	MESH:D002518	53947	Chemical	Gene	START_ENTITY|nsubj|synthesis synthesis|nmod|END_ENTITY	Enzymatic synthesis of Gb3 and iGb3 ceramides .
17647040	0	ceramides	41,50	apolipoprotein_B-100	77,97	ceramides	apolipoprotein B-100	MESH:D002518	238055(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of dietary cholesterol on tissue ceramides and oxidation products of apolipoprotein_B-100 in ApoE-deficient mice .
17337731	0	ceramides	13,22	insulin	36,43	ceramides	insulin	MESH:D002518	3630	Chemical	Gene	START_ENTITY|acl|mediating mediating|dobj|resistance resistance|compound|END_ENTITY	Key role for ceramides in mediating insulin resistance in human muscle cells .
17339023	0	ceramides	43,52	insulin	12,19	ceramides	insulin	MESH:D002518	3630	Chemical	Gene	paved|nmod|START_ENTITY path|dep|paved path|nmod|resistance resistance|compound|END_ENTITY	The path to insulin resistance : paved with ceramides ?
19008343	0	ceramides	7,16	insulin	104,111	ceramides	insulin	MESH:D002518	3630	Chemical	Gene	elevated|nsubj|START_ENTITY elevated|nmod|severity severity|nmod|resistance resistance|compound|END_ENTITY	Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance .
21873552	0	ceramides	52,61	insulin	65,72	ceramides	insulin	MESH:D002518	3630	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	Skeletal muscle triglycerides , diacylglycerols , and ceramides in insulin resistance : another paradox in endurance-trained athletes ?
6549145	0	cerebroside	30,41	galactosylceramidase	61,81	cerebroside	galactosylceramidase	CHEBI:23079	2581	Chemical	Gene	START_ENTITY|nmod|substrate substrate|nmod|END_ENTITY	-LSB- Use of fluorescence-labelled cerebroside as a substrate for galactosylceramidase of human skin fibroblasts -RSB- .
6191512	0	cerebroside	13,24	myelin_basic_protein	77,97	cerebroside	myelin basic protein	CHEBI:23079	100731253	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|activity activity|nmod|END_ENTITY	Influence of cerebroside and ganglioside on the encephalitogenic activity of myelin_basic_protein in guinea_pigs .
2408668	0	cerebroside_sulfate	77,96	myelin_basic_protein	15,35	cerebroside sulfate	myelin basic protein	MESH:C083015	4155	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of myelin_basic_protein and polylysine with synthetic species of cerebroside_sulfate .
1693915	0	cerebroside_sulfate	74,93	substance_P	57,68	cerebroside sulfate	substance P	MESH:C083015	6863	Chemical	Gene	Evidence|nmod|START_ENTITY Evidence|nmod|interaction interaction|nmod|END_ENTITY	Evidence of neuropeptide bivalency in the interaction of substance_P with cerebroside_sulfate .
2856894	0	cerebroside_sulfate	22,41	sulfatase	42,51	cerebroside sulfate	sulfatase	MESH:C083015	347527	Chemical	Gene	Prevalence|nmod|START_ENTITY END_ENTITY|nsubj|Prevalence	Prevalence of partial cerebroside_sulfate sulfatase -LRB- arylsulfatase_A -RRB- defect in adult psychiatric patients .
2889546	0	cerebroside_sulfate	10,29	sulfatase	42,51	cerebroside sulfate	sulfatase	MESH:C083015	347527	Chemical	Gene	Assay|nmod|START_ENTITY END_ENTITY|nsubj|Assay	Assay for cerebroside_sulfate -LRB- sulfatide -RRB- sulfatase in cultured skin fibroblasts with the natural activator protein .
8464952	0	cerebrospinal	25,38	corticotropin-releasing_factor	63,93	cerebrospinal	corticotropin-releasing factor	null	1392	Chemical	Gene	concentrations|amod|START_ENTITY concentrations|nmod|END_ENTITY	Effect of desipramine on cerebrospinal fluid concentrations of corticotropin-releasing_factor in human subjects .
11238259	0	cerivastatin	43,55	C-reactive_protein	19,37	cerivastatin	C-reactive protein	MESH:C086276	1401	Chemical	Gene	reduction|nmod|START_ENTITY reduction|nmod|END_ENTITY	Rapid reduction in C-reactive_protein with cerivastatin among 785 patients with primary_hypercholesterolemia .
15492479	0	cerivastatin	10,22	CD36	61,65	cerivastatin	CD36	MESH:C086276	29184(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of cerivastatin on endothelial_dysfunction and aortic CD36 expression in diabetic_hyperlipidemic rats .
17287218	0	cerivastatin	59,71	HMG-CoA-reductase	31,48	cerivastatin	HMG-CoA-reductase	MESH:C086276	15357(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|inhibitor inhibitor|amod|END_ENTITY	Nephroprotective effect of the HMG-CoA-reductase inhibitor cerivastatin in a mouse model of progressive_renal_fibrosis in Alport_syndrome .
11209008	0	cerivastatin	71,83	HMG-CoA_reductase	42,59	cerivastatin	HMG-CoA reductase	MESH:C086276	3156	Chemical	Gene	inhibitors|dobj|START_ENTITY inhibitors|nsubj|interactions interactions|nmod|END_ENTITY	Efficacy and drug interactions of the new HMG-CoA_reductase inhibitors cerivastatin and atorvastatin in CsA-treated renal transplant recipients .
12531431	0	cerivastatin	51,63	HMG-CoA_reductase	81,98	cerivastatin	HMG-CoA reductase	MESH:C086276	3156	Chemical	Gene	activity|nmod|START_ENTITY mechanism|nmod|activity mechanism|appos|inhibitor inhibitor|nmod|END_ENTITY	Molecular mechanism of the anti-cancer activity of cerivastatin , an inhibitor of HMG-CoA_reductase , on aggressive human breast_cancer cells .
9737641	0	cerivastatin	33,45	HMG-CoA_reductase	55,72	cerivastatin	HMG-CoA reductase	MESH:C086276	25675(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Preclinical safety evaluation of cerivastatin , a novel HMG-CoA_reductase inhibitor .
15550721	0	cerivastatin	121,133	cyclosporin_A	61,74	cerivastatin	cyclosporin A	MESH:C086276	1161	Chemical	Gene	uptake|nmod|START_ENTITY END_ENTITY|nmod|uptake	In vitro and in vivo correlation of the inhibitory effect of cyclosporin_A on the transporter-mediated hepatic uptake of cerivastatin in rats .
12953163	0	cerivastatin	28,40	interleukin-6	50,63	cerivastatin	interleukin-6	MESH:C086276	3569	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	HMG-CoA_reductase inhibitor cerivastatin inhibits interleukin-6 expression and secretion in human adipocytes .
15194707	0	cerivastatin	167,179	organic_anion_transporting_polypeptide_2	44,84	cerivastatin	organic anion transporting polypeptide 2	MESH:C086276	10599	Chemical	Gene	metabolism|nmod|START_ENTITY END_ENTITY|dep|metabolism	Gemfibrozil and its glucuronide inhibit the organic_anion_transporting_polypeptide_2 -LRB- OATP2/OATP1B1 : SLC21A6 -RRB- - mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin : analysis of the mechanism of the clinically relevant drug-drug interaction between cerivastatin and gemfibrozil .
9663363	0	cerivastatin_sodium	11,30	HMG-CoA_reductase	38,55	cerivastatin sodium	HMG-CoA reductase	MESH:C086276	3156	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effects of cerivastatin_sodium , a new HMG-CoA_reductase inhibitor , on biliary lipid metabolism in patients with hypercholesterolemia .
9358961	0	cerivastatin_sodium	80,99	LDL_receptor	64,76	cerivastatin sodium	LDL receptor	MESH:C086276	3949	Chemical	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	Reduction of plasma cholesterol levels and induction of hepatic LDL_receptor by cerivastatin_sodium -LRB- CAS_143201-11-0 , _ BAY_w_6228 -RRB- , a new inhibitor of 3-hydroxy-3-methylglutaryl_coenzyme_A_reductase , in dogs .
1331844	6	ceronapril	896,906	ACE	839,842	ceronapril	ACE	MESH:C054518	24310(Tax:10116)	Chemical	Gene	administration|nmod|START_ENTITY lasted|nmod|administration lasted|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of ACE in kidney lasted up to 48 hr after administration of ceronapril , whereas the activity of ACE in plasma and lung recovered rapidly -LRB- 8 hr -RRB- .
8792940	0	ceronapril	28,38	ACE	14,17	ceronapril	ACE	MESH:C054518	1636	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|inhibitor inhibitor|compound|END_ENTITY	Effect of the ACE inhibitor ceronapril on cerebral blood flow in hypertensive patients .
17384272	5	cerulein	956,964	AIF	1006,1009	cerulein	AIF	MESH:D002108	83533(Tax:10116)	Chemical	Gene	induced|nsubj|START_ENTITY induced|dobj|expression expression|nmod|END_ENTITY	As a result , cerulein induced the expression of apoptotic gene AIF .
10881937	0	cerulein	35,43	IL-6	53,57	cerulein	IL-6	MESH:D002108	3569	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Induction of acute pancreatitis by cerulein in human IL-6 gene transgenic_mice .
16764691	0	cerulein	90,98	peroxisome_proliferator-activated_receptor-alpha	8,56	cerulein	peroxisome proliferator-activated receptor-alpha	MESH:D002108	19013(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Role Role|nmod|END_ENTITY	Role of peroxisome_proliferator-activated_receptor-alpha in acute pancreatitis induced by cerulein .
23181152	2	cerulenin	304,313	FASN	279,283	cerulenin	FASN	MESH:D002569	2194	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	The ocular_cancer , retinoblastoma cells were treated with fatty_acid synthase -LRB- FASN -RRB- enzyme inhibitors : cerulenin , triclosan and orlistat .
6756301	0	cerulenin	80,89	beta-lactamase	13,27	cerulenin	beta-lactamase	MESH:D002569	7872529(Tax:562)	Chemical	Gene	effect|nmod|START_ENTITY Secretion|dep|effect Secretion|nmod|END_ENTITY	Secretion of beta-lactamase by Escherichia_coli in vivo and in vitro : effect of cerulenin .
3019002	0	cerulenin	14,23	gag	58,61	cerulenin	gag	MESH:D002569	17276(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nsubj|effect	The effect of cerulenin on the synthesis of the precursor gag polyprotein in defective_murine_leukemia and sarcoma_virus producing cell lines .
10777486	0	ceruloplasmin	68,81	hypoxia-inducible_factor-1	8,34	ceruloplasmin	hypoxia-inducible factor-1	null	3091	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of hypoxia-inducible_factor-1 in transcriptional activation of ceruloplasmin by iron_deficiency .
202979	0	ceruloplasmin	19,32	transferrin	42,53	ceruloplasmin	transferrin	null	7018	Chemical	Gene	study|nmod|START_ENTITY END_ENTITY|nsubj|study	EPR study of serum ceruloplasmin and iron transferrin in myocardial_infarction .
24418516	0	ceruloplasmin	30,43	transferrin	47,58	ceruloplasmin	transferrin	null	7018	Chemical	Gene	uptake|nmod|START_ENTITY uptake|nmod|END_ENTITY	Iron uptake and transfer from ceruloplasmin to transferrin .
18198280	0	cesium_chloride	85,100	Hog1	8,12	cesium chloride	Hog1	MESH:C028019	850803(Tax:4932)	Chemical	Gene	Role|acl|START_ENTITY Role|nmod|END_ENTITY	Role of Hog1 and Yaf9 in the transcriptional response of Saccharomyces_cerevisiae to cesium_chloride .
12787835	0	cetirizine	36,46	Histamine_H1_receptor	0,21	cetirizine	Histamine H1 receptor	MESH:D017332	100135539(Tax:10141)	Chemical	Gene	antagonism|nmod|START_ENTITY antagonism|amod|END_ENTITY	Histamine_H1_receptor antagonism by cetirizine in isolated guinea_pig tissues : influence of receptor reserve and dissociation kinetics .
10195357	0	cetirizine	107,117	substance_P	23,34	cetirizine	substance P	MESH:D017332	6863	Chemical	Gene	effect|nmod|START_ENTITY responses|dep|effect responses|nmod|END_ENTITY	Cutaneous responses to substance_P and calcitonin_gene-related_peptide in chronic urticaria : the effect of cetirizine and dimethindene .
16196274	0	cetirizine_hydrochloride	11,35	substance_P	57,68	cetirizine hydrochloride	substance P	null	21333(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of cetirizine_hydrochloride on the expression of substance_P in IgE-mediated triphasic cutaneous reaction -RSB- .
15536154	0	cetrorelix	42,52	Gonadotropin-releasing_hormone	0,30	cetrorelix	Gonadotropin-releasing hormone	MESH:C062876	2796	Chemical	Gene	proliferating_cell_nuclear_antigen|compound|START_ENTITY proliferating_cell_nuclear_antigen|amod|END_ENTITY	Gonadotropin-releasing_hormone antagonist cetrorelix down-regulates proliferating_cell_nuclear_antigen and epidermal_growth_factor expression and up-regulates apoptosis in association with enhanced poly -LRB- adenosine_5 ' - diphosphate-ribose -RRB- polymerase expression in cultured human leiomyoma cells .
10685535	0	cetrorelix	166,176	LH-RH	147,152	cetrorelix	LH-RH	MESH:C062876	2796	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|appos|END_ENTITY	Prospective , randomized , controlled study of in vitro fertilization-embryo transfer with a single dose of a luteinizing_hormone-releasing_hormone -LRB- LH-RH -RRB- antagonist -LRB- cetrorelix -RRB- or a depot formula of an LH-RH agonist -LRB- triptorelin -RRB- .
11180022	0	cetrorelix	48,58	LH-RH	63,68	cetrorelix	LH-RH	MESH:C062876	2796	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Pharmacokinetic and pharmacodynamic modeling of cetrorelix , an LH-RH antagonist , after subcutaneous administration in healthy premenopausal women .
21062912	0	cetrorelix	58,68	LHRH	39,43	cetrorelix	LHRH	MESH:C062876	2796	Chemical	Gene	inhibits|nsubj|START_ENTITY antagonist|ccomp|inhibits Luteinizing|parataxis|antagonist Luteinizing|dobj|Hormone Hormone|appos|END_ENTITY	Luteinizing Hormone-Releasing Hormone -LRB- LHRH -RRB- - I antagonist cetrorelix inhibits myeloma cell growth in vitro and in vivo .
10611134	0	cetrorelix	30,40	luteinizing_hormone-releasing_hormone	51,88	cetrorelix	luteinizing hormone-releasing hormone	MESH:C062876	25194(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Disposition and metabolism of cetrorelix , a potent luteinizing_hormone-releasing_hormone antagonist , in rats and dogs .
10685535	0	cetrorelix	166,176	luteinizing_hormone-releasing_hormone	108,145	cetrorelix	luteinizing hormone-releasing hormone	MESH:C062876	2796	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Prospective , randomized , controlled study of in vitro fertilization-embryo transfer with a single dose of a luteinizing_hormone-releasing_hormone -LRB- LH-RH -RRB- antagonist -LRB- cetrorelix -RRB- or a depot formula of an LH-RH agonist -LRB- triptorelin -RRB- .
25286222	0	cetylpyridinium_chloride	72,96	transferrin	41,52	cetylpyridinium chloride	transferrin	MESH:D002594	7018	Chemical	Gene	process|nmod|START_ENTITY process|nmod|END_ENTITY	The unfolding process of apo-human serum transferrin in the presence of cetylpyridinium_chloride : an isothermal titration calorimetry study .
21979880	0	chaetocin	26,35	SUV39H1	129,136	chaetocin	SUV39H1	MESH:C002511	6839	Chemical	Gene	activity|nmod|START_ENTITY activity|nmod|END_ENTITY	Anti-leukemia activity of chaetocin via death receptor-dependent apoptosis and dual modulation of the histone methyl-transferase SUV39H1 .
18999987	0	chaetocin	21,30	thioredoxin_reductase	75,96	chaetocin	thioredoxin reductase	MESH:C002511	25824	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	The anticancer agent chaetocin is a competitive substrate and inhibitor of thioredoxin_reductase .
11014257	0	chalcone	14,22	5alpha-reductase	28,44	chalcone	5alpha-reductase	MESH:D002599	6715	Chemical	Gene	START_ENTITY|nmod|properties properties|amod|END_ENTITY	A geranylated chalcone with 5alpha-reductase inhibitory properties from Artocarpus incisus .
21539383	0	chalcone	6,14	Nrf2	37,41	chalcone	Nrf2	MESH:D002599	18024(Tax:10090)	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	Novel chalcone derivatives as potent Nrf2 activators in mice and human lung epithelial cells .
24613626	0	chalcone	60,68	P-glycoprotein	104,118	chalcone	P-glycoprotein	MESH:D002599	5243	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|inhibitors inhibitors|nmod|END_ENTITY	Synthesis , biological evaluation and 3D-QSAR studies of new chalcone derivatives as inhibitors of human P-glycoprotein .
24109177	0	chalcone	40,48	breast_cancer_resistance_protein	63,95	chalcone	breast cancer resistance protein	MESH:D002599	9429	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	New structure-activity relationships of chalcone inhibitors of breast_cancer_resistance_protein : polyspecificity toward inhibition and critical substitutions against cytotoxicity .
24243608	0	chalcone	10,18	cathepsins_K_and_B	48,66	chalcone	cathepsins K and B	MESH:D002599	1513;1508	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Synthetic chalcone derivatives as inhibitors of cathepsins_K_and_B , and their cytotoxic evaluation .
15231412	5	chalcone	527,535	tyrosinase	462,472	chalcone	tyrosinase	MESH:D002599	7299	Chemical	Gene	family|amod|START_ENTITY characterize|dobj|family aims|xcomp|characterize aims|advcl|showing showing|ccomp|inhibitor inhibitor|compound|END_ENTITY	51 -LRB- 2003 -RRB- 1201 -RSB- , showing that isoliquiritigenin_chalcone -LRB- ILC -RRB- is a potent tyrosinase inhibitor , the present study aims to characterize the chalcone family as new tyrosinase inhibitors , and demonstrate their potential whitening potency .
23018855	0	chalcone	18,26	tyrosinase	55,65	chalcone	tyrosinase	MESH:D002599	22173(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	A novel bioactive chalcone of Morus australis inhibits tyrosinase activity and melanin biosynthesis in B16 melanoma cells .
18702457	0	chalcone_adamantyl_arotinoids	69,98	IkappaB_kinase-beta	14,33	chalcone adamantyl arotinoids	IkappaB kinase-beta	null	3551	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activities activities|amod|END_ENTITY	Inhibition of IkappaB_kinase-beta and anticancer activities of novel chalcone_adamantyl_arotinoids .
24920885	0	chalcones	24,33	ABCG2	88,93	chalcones	ABCG2	MESH:D047188	9429	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Quinoxaline-substituted chalcones as new inhibitors of breast_cancer_resistance_protein ABCG2 : polyspecificity at B-ring position .
24747187	0	chalcones	106,115	DNA_gyrase	121,131	chalcones	DNA gyrase	MESH:D047188	7153	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|compound|END_ENTITY	Synthesis , characterization , theoretical , anti-bacterial and molecular docking studies of quinoline based chalcones as a DNA_gyrase inhibitor .
17964170	0	chalcones	15,24	P-glycoprotein	52,66	chalcones	P-glycoprotein	MESH:D047188	5243	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Functionalized chalcones as selective inhibitors of P-glycoprotein and breast_cancer_resistance_protein .
23805528	0	chalcones	20,29	PI3K	56,60	chalcones	PI3K	MESH:D047188	298947(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of ashitabe chalcones on the mRNA expression of PI3K and Akt in hepatocytes of rats with diabetes -RSB- .
23203129	0	chalcones	37,46	TRAIL-R2	25,33	chalcones	TRAIL-R2	MESH:D047188	8795	Chemical	Gene	Targeting|nmod|START_ENTITY Targeting|dobj|END_ENTITY	Targeting death receptor TRAIL-R2 by chalcones for TRAIL-induced apoptosis in cancer cells .
21782455	0	chalcones	78,87	angiotensin_converting_enzyme	105,134	chalcones	angiotensin converting enzyme	MESH:D047188	1636	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Synthesis and evaluation of novel 2-butyl-4-chloro-1-methylimidazole embedded chalcones and pyrazoles as angiotensin_converting_enzyme -LRB- ACE -RRB- inhibitors .
22449016	0	chalcones	17,26	breast_cancer_resistance_protein	58,90	chalcones	breast cancer resistance protein	MESH:D047188	9429	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Investigation of chalcones as selective inhibitors of the breast_cancer_resistance_protein : critical role of methoxylation in both inhibition potency and cytotoxicity .
17146965	0	chalcones	47,56	interleukin-5	78,91	chalcones	interleukin-5	MESH:D047188	3567	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	The role of the hydrophobic group on ring A of chalcones in the inhibition of interleukin-5 .
26974383	0	chalcones	30,39	monoamine_oxidase-B	60,79	chalcones	monoamine oxidase-B	MESH:D047188	4129	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Design and synthesis of novel chalcones as potent selective monoamine_oxidase-B inhibitors .
23183544	0	chalcones	56,65	peroxisome_proliferator-activated_receptor_gamma	87,135	chalcones	peroxisome proliferator-activated receptor gamma	MESH:D047188	5468	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Effects of structural and electronic characteristics of chalcones on the activation of peroxisome_proliferator-activated_receptor_gamma .
23257392	0	chalepensin	70,81	CYP1A1	30,36	chalepensin	CYP1A1	MESH:C020740	1543	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Mechanism-based inhibition of CYP1A1 and CYP3A4 by the furanocoumarin chalepensin .
23257392	1	chalepensin	129,140	CYP1A1	168,174	chalepensin	CYP1A1	MESH:C020740	1543	Chemical	Gene	found|nsubjpass|START_ENTITY found|xcomp|inhibit inhibit|dobj|END_ENTITY	The cytochrome_P450 _ -LRB- P450 , _ CYP -RRB- _ 2A6 inhibitor chalepensin was found to inhibit human CYP1A1 , CYP1A2 , CYP2A13 , CYP2C9 , CYP2D6 , CYP2E1 , and CYP3A4 to different extents .
17920518	0	chaperone	53,62	Lectin-like_oxidized_LDL_receptor-1	0,35	chaperone	Lectin-like oxidized LDL receptor-1	null	4973	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	Lectin-like_oxidized_LDL_receptor-1 as extracellular chaperone receptor : its versatile functions and human diseases .
15295108	0	chaperone	5,14	protein_disulfide_isomerase	42,69	chaperone	protein disulfide isomerase	null	64714	Chemical	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	Both chaperone and isomerase functions of protein_disulfide_isomerase are essential for acceleration of the oxidative refolding and reactivation of dimeric alkaline protease inhibitor .
11422376	0	chaperonin	44,54	chaperonin_60	115,128	chaperonin	chaperonin 60	null	3329	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	The effect of nucleotides and mitochondrial chaperonin 10 on the structure and chaperone activity of mitochondrial chaperonin_60 .
11493562	6	chelerythrine	805,818	PKC	829,832	chelerythrine	Shh	MESH:C016299	395615(Tax:9031)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Application of chelerythrine , a potent PKC inhibitor , to the presumptive wing region resulted in buds that did not express sonic hedgehog -LRB- Shh -RRB- and developed into wings that were severely truncated .
19554423	9	chelerythrine	1625,1638	PKC	1516,1519	chelerythrine	ODC	MESH:C016299	24609(Tax:10116)	Chemical	Gene	downregulated|nsubj|START_ENTITY upregulated|advcl|downregulated upregulated|nsubj|activation activation|nmod|END_ENTITY	Conversely , activation of PKC by phorbol_12-myristate_13-acetate -LRB- PMA -RRB- upregulated the ODC/polyamine system , whereas the PKC inhibitor chelerythrine -LRB- Che -RRB- downregulated the ODC/polyamine system .
21291962	0	chelerythrine	11,24	cyclooxygenase-2	50,66	chelerythrine	cyclooxygenase-2	MESH:C016299	19225(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|inhibitor inhibitor|nmod|END_ENTITY	Effects of chelerythrine , a specific inhibitor of cyclooxygenase-2 , on acute inflammation in mice .
21320026	0	chelidonic_acid	22,37	IL-6	41,45	chelidonic acid	IL-6	MESH:C046884	3569	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Inhibitory effects of chelidonic_acid on IL-6 production by blocking NF-kB and caspase-1 in HMC-1 cells .
12385778	0	chenodeoxycholic_acid	39,60	CYP27A1	24,31	chenodeoxycholic acid	CYP27A1	MESH:D002635	1593	Chemical	Gene	START_ENTITY|nsubj|inhibition inhibition|nmod|END_ENTITY	Selective inhibition of CYP27A1 and of chenodeoxycholic_acid synthesis in cholestatic hamster liver .
6806274	0	chenodeoxycholic_acid	99,120	UDP-glucuronosyltransferase	55,82	chenodeoxycholic acid	UDP-glucuronosyltransferase	MESH:D002635	24862(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Isolation and characterization of rat liver microsomal UDP-glucuronosyltransferase activity toward chenodeoxycholic_acid and testosterone as a single form of enzyme .
17999771	0	chetomin	31,39	HIF-1	11,16	chetomin	HIF-1	MESH:C001598	3091	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|Effects Effects|nmod|END_ENTITY	Effects of HIF-1 inhibition by chetomin on hypoxia-related transcription and radiosensitivity in HT 1080 human fibrosarcoma cells .
10908041	0	chlomethiazole	22,36	c-fos	48,53	chlomethiazole	c-fos	null	2353	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|END_ENTITY	Neuroprotective agent chlomethiazole attenuates c-fos , c-jun , and AP-1 activation through inhibition of p38_MAP_kinase .
10215662	0	chlomethiazole	68,82	cytochrome_P-450_2E1	33,53	chlomethiazole	cytochrome P-450 2E1	null	1571	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|expression expression|amod|END_ENTITY	Post-translational inhibition of cytochrome_P-450_2E1 expression by chlomethiazole in Fao hepatoma cells .
10908041	0	chlomethiazole	22,36	p38_MAP_kinase	104,118	chlomethiazole	p38 MAP kinase	null	1432	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|nmod|inhibition inhibition|nmod|END_ENTITY	Neuroprotective agent chlomethiazole attenuates c-fos , c-jun , and AP-1 activation through inhibition of p38_MAP_kinase .
7047147	0	chloralose-urethane	39,58	LHRH	81,85	chloralose-urethane	LHRH	null	25194(Tax:10116)	Chemical	Gene	anesthesia|amod|START_ENTITY anesthesia|nmod|END_ENTITY	Differential effect of althesin versus chloralose-urethane anesthesia on in vivo LHRH and LH release in the proestrous rat .
11071881	0	chlorambucil	80,92	glutathione_S-transferase	47,72	chlorambucil	glutathione S-transferase	MESH:D002699	373156	Chemical	Gene	Activity|nmod|START_ENTITY Activity|nmod|END_ENTITY	Activity of allelic variants of Pi class human glutathione_S-transferase toward chlorambucil .
15356922	0	chlorambucil	14,26	glutathione_S-transferase	51,76	chlorambucil	glutathione S-transferase	MESH:D002699	58962(Tax:10116)	Chemical	Gene	Metabolism|nmod|START_ENTITY microsomal|nsubj|Metabolism microsomal|xcomp|END_ENTITY	Metabolism of chlorambucil by rat liver microsomal glutathione_S-transferase .
7680202	0	chlorambucil	95,107	glutathione_S-transferase	15,40	chlorambucil	glutathione S-transferase	MESH:D002699	58962(Tax:10116)	Chemical	Gene	exposure|amod|START_ENTITY course|nmod|exposure course|nmod|elevation elevation|amod|END_ENTITY	Time course of glutathione_S-transferase elevation in Walker mammary_carcinoma cells following chlorambucil exposure .
8877534	0	chloramphenicol	8,23	CAT_III	0,7	chloramphenicol	CAT III	MESH:D002701	875743(Tax:75985)	Chemical	Gene	resistance|amod|START_ENTITY resistance|compound|END_ENTITY	CAT_III chloramphenicol resistance in Pasteurella_haemolytica and Pasteurella_multocida isolated from calves .
4583232	0	chloramphenicol	20,35	R1_and_R100-1	57,70	chloramphenicol	R1 and R100-1	MESH:D002701	6240	Chemical	Gene	region|amod|START_ENTITY region|nmod|END_ENTITY	Deletion map of the chloramphenicol resistance region of R1_and_R100-1 .
7647146	0	chloramphenicol	14,29	glutathione_S-transferase	33,58	chloramphenicol	glutathione S-transferase	MESH:D002701	373156	Chemical	Gene	Metabolism|nmod|START_ENTITY Metabolism|nmod|END_ENTITY	Metabolism of chloramphenicol by glutathione_S-transferase in human fetal and neonatal liver .
8123884	0	chloramphenicol	14,29	intestinal_alkaline_phosphatase	86,117	chloramphenicol	intestinal alkaline phosphatase	MESH:D002701	11648(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|role role|nmod|END_ENTITY	The effect of chloramphenicol on mucosal transference of glucose in mice ; the role of intestinal_alkaline_phosphatase in this process .
24458789	0	chloramphenicol	34,49	nitrate_reductase	13,30	chloramphenicol	nitrate reductase	MESH:D002701	101219000	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of nitrate_reductase by chloramphenicol in detached cucumber cotyledons .
19423354	0	chloramphenicol_amine	30,51	aminopeptidase_N	74,90	chloramphenicol amine	aminopeptidase N	null	290	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	Design and synthesis of novel chloramphenicol_amine derivatives as potent aminopeptidase_N -LRB- APN/CD13 -RRB- inhibitors .
16143849	0	chlorate	115,123	nitrate_reductase	45,62	chlorate	nitrate reductase	CHEBI:49709	5722285(Tax:3055)	Chemical	Gene	resistant|amod|START_ENTITY mutants|amod|resistant isolation|nmod|mutants strains|dep|isolation strains|acl|expressing expressing|dobj|END_ENTITY	Chlamydomonas_reinhardtii strains expressing nitrate_reductase under control of the cabII-1 promoter : isolation of chlorate resistant mutants and identification of new loci for nitrate assimilation .
1284994	0	chlordecone	86,97	CCl4	78,82	chlordecone	CCl4	MESH:D007631	116637(Tax:10116)	Chemical	Gene	rats|amod|START_ENTITY END_ENTITY|nmod|rats	Pivotal role of hepatocellular regeneration in the ultimate hepatotoxicity of CCl4 in chlordecone - , mirex - , or phenobarbital-pretreated rats .
19159673	0	chlordiazepoxide	134,150	IL-19	67,72	chlordiazepoxide	IL-19	MESH:D002707	329244(Tax:10090)	Chemical	Gene	reversal|nmod|START_ENTITY END_ENTITY|dep|reversal	Psychological stress increases expression of IL-10 and its homolog IL-19 via beta-adrenoceptor activation : reversal by the anxiolytic chlordiazepoxide .
17458068	0	chlorhexidine_mouthrinse	10,34	cathepsin_C	38,49	chlorhexidine mouthrinse	cathepsin C	null	1075	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	Effect of chlorhexidine_mouthrinse on cathepsin_C activity in human saliva .
10353703	0	chloride	33,41	AE1	108,111	chloride	AE1	CHEBI:17996	6521	Chemical	Gene	Mechanism|nmod|START_ENTITY Mechanism|nmod|3 3|appos|END_ENTITY	Mechanism of competition between chloride and stilbenedisulfonates for binding to human erythrocyte band 3 -LRB- AE1 -RRB- .
12578372	0	chloride	58,66	AE1	163,166	chloride	AE1	CHEBI:17996	6521	Chemical	Gene	interacts|nmod|START_ENTITY chain|nmod|interacts site|nsubj|chain site|dep|END_ENTITY	The carboxyl side chain of glutamate_681 interacts with a chloride binding modifier site that allosterically modulates the dimeric conformational state of band 3 -LRB- AE1 -RRB- .
23383138	0	chloride	24,32	AE1	47,50	chloride	AE1	CHEBI:17996	6521	Chemical	Gene	transporters|compound|START_ENTITY transporters|appos|END_ENTITY	Regulation of two renal chloride transporters , AE1 and pendrin , by electrolytes and aldosterone .
150603	0	chloride	11,19	ATPase	44,50	chloride	ATPase	CHEBI:17996	1769	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of chloride , nitrate and sulfate on ATPase of renal cortex and medulla .
19274342	0	chloride	70,78	ATPase	60,66	chloride	ATPase	CHEBI:17996	1769	Chemical	Gene	ions|compound|START_ENTITY END_ENTITY|nmod|ions	Physiological implications of the regulation of vacuolar H + - ATPase by chloride ions .
18329299	0	chloride	23,31	Ae1	47,50	chloride	Ae1	CHEBI:17996	20533(Tax:10090)	Chemical	Gene	conductance|compound|START_ENTITY conductance|nmod|END_ENTITY	Reduced DIDS-sensitive chloride conductance in Ae1 - / - mouse erythrocytes .
25080489	0	chloride	70,78	Angiotensin_II	0,14	chloride	Angiotensin II	CHEBI:17996	11606(Tax:10090)	Chemical	Gene	ions|compound|START_ENTITY conductance|nmod|ions modulates|dobj|conductance modulates|nsubj|END_ENTITY	Angiotensin_II modulates mouse skeletal muscle resting conductance to chloride and potassium ions and calcium homeostasis via the AT1_receptor and NADPH oxidase .
3782465	0	chloride	59,67	Angiotensin_II	0,14	chloride	Angiotensin II	CHEBI:17996	24179(Tax:10116)	Chemical	Gene	conductance|compound|START_ENTITY stimulate|dobj|conductance stimulate|nsubj|END_ENTITY	Angiotensin_II and vasopressin stimulate calcium-activated chloride conductance in rat mesangial cells .
24420770	0	chloride	33,41	Ano1	18,22	chloride	Ano1	CHEBI:17996	55107	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Activation of the Ano1 -LRB- TMEM16A -RRB- chloride channel by calcium is not mediated by calmodulin .
26530828	0	chloride	32,40	Ano1	50,54	chloride	Ano1	CHEBI:17996	101772(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY Expression|nmod|channels Expression|dep|END_ENTITY	Expression of calcium-activated chloride channels Ano1 and Ano2 in mouse taste cells .
23653216	0	chloride	39,47	AtALMT9	0,7	chloride	AtALMT9	CHEBI:17996	821373(Tax:3702)	Chemical	Gene	channel|compound|START_ENTITY channel|nsubj|END_ENTITY	AtALMT9 is a malate-activated vacuolar chloride channel required for stomatal opening in Arabidopsis .
1852106	0	chloride	23,31	Atriopeptin	0,11	chloride	Atriopeptin	CHEBI:17996	4878	Chemical	Gene	secretion|compound|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Atriopeptin stimulates chloride secretion in cultured shark rectal gland cells .
16912113	0	chloride	46,54	Bestrophin-2	0,12	chloride	Bestrophin-2	CHEBI:17996	212989(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY channel|nsubj|END_ENTITY	Bestrophin-2 is a candidate calcium-activated chloride channel involved in olfactory transduction .
1710448	0	chloride	37,45	Bombesin	0,8	chloride	Bombesin	CHEBI:17996	2922	Chemical	Gene	channels|compound|START_ENTITY activates|dobj|channels activates|nsubj|END_ENTITY	Bombesin activates large-conductance chloride channels in Swiss 3T3 fibroblasts .
9115758	0	chloride	37,45	C-type_natriuretic_peptide	0,26	chloride	C-type natriuretic peptide	CHEBI:17996	4880	Chemical	Gene	START_ENTITY|nsubj|increases increases|amod|END_ENTITY	C-type_natriuretic_peptide increases chloride permeability in normal and cystic_fibrosis airway cells .
10191357	0	chloride	117,125	CFTR	53,57	chloride	CFTR	CHEBI:17996	12638(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY confers|nmod|channel confers|nsubj|Cystic_fibrosis_transmembrane_conductance_regulator Cystic_fibrosis_transmembrane_conductance_regulator|appos|END_ENTITY	Cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- confers glibenclamide sensitivity to outwardly rectifying chloride channel -LRB- ORCC -RRB- in Hi-5 insect cells .
10223721	0	chloride	12,20	CFTR	58,62	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	indicators|compound|START_ENTITY Fluorescent|dobj|indicators Fluorescent|xcomp|assess assess|dobj|efficacy efficacy|nmod|delivery delivery|amod|END_ENTITY	Fluorescent chloride indicators to assess the efficacy of CFTR cDNA delivery .
10516209	0	chloride	20,28	CFTR	0,4	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	bicarbonate|compound|START_ENTITY involvement|nmod|bicarbonate involvement|amod|END_ENTITY	CFTR involvement in chloride , bicarbonate , and liquid secretion by airway submucosal glands .
10551285	0	chloride	30,38	CFTR	25,29	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Potent inhibition of the CFTR chloride channel by suramin .
10790148	0	chloride	93,101	CFTR	88,92	chloride	CFTR	CHEBI:17996	12638(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Deletion_of_phenylalanine_508 causes attenuated phosphorylation-dependent activation of CFTR chloride channels .
11130462	0	chloride	22,30	CFTR	17,21	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	regulation|compound|START_ENTITY regulation|amod|END_ENTITY	New paradigms of CFTR chloride channel regulation .
11159718	0	chloride	19,27	CFTR	14,18	chloride	CFTR	CHEBI:17996	12638(Tax:10090)	Chemical	Gene	openers|compound|START_ENTITY openers|amod|END_ENTITY	Assessment of CFTR chloride channel openers in intact normal and cystic_fibrosis_murine_epithelia .
11266369	0	chloride	69,77	CFTR	64,68	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Non-specific activation of the epithelial sodium channel by the CFTR chloride channel .
11600438	0	chloride	68,76	CFTR	63,67	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	transport|compound|START_ENTITY transport|amod|END_ENTITY	Cell-based assay for high-throughput quantitative screening of CFTR chloride transport agonists .
11606326	0	chloride	37,45	CFTR	32,36	chloride	CFTR	CHEBI:17996	12638(Tax:10090)	Chemical	Gene	openers|compound|START_ENTITY openers|amod|END_ENTITY	Phenanthrolines -- a new class of CFTR chloride channel openers .
11889571	0	chloride	97,105	CFTR	92,96	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Point mutations in the pore region directly or indirectly affect glibenclamide_block of the CFTR chloride channel .
11948203	0	chloride	85,93	CFTR	40,44	chloride	CFTR	CHEBI:17996	105927055	Chemical	Gene	cells|compound|START_ENTITY channel|nmod|cells channel|amod|END_ENTITY	Redistribution of immunofluorescence of CFTR anion channel and NKCC cotransporter in chloride cells during adaptation of the killifish Fundulus_heteroclitus to sea water .
12080183	0	chloride	57,65	CFTR	98,102	chloride	CFTR	CHEBI:17996	24255(Tax:10116)	Chemical	Gene	conductance|compound|START_ENTITY conductance|nmod|cells cells|acl|expressing expressing|dobj|F508 F508|compound|END_ENTITY	A novel natural product compound enhances cAMP-regulated chloride conductance of cells expressing CFTR -LSB- delta -RSB- F508 .
12209004	0	chloride	5,13	CFTR	0,4	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	CFTR chloride channels are regulated by a SNAP-23 / syntaxin_1A complex .
12411425	0	chloride	47,55	CFTR	42,46	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Mechanism of lonidamine inhibition of the CFTR chloride channel .
12679372	0	chloride	91,99	CFTR	86,90	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Molecular determinants and role of an anion binding site in the external mouth of the CFTR chloride channel pore .
12711306	0	chloride	28,36	CFTR	23,27	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Functional analysis of CFTR chloride channel activity in cells with elevated MDR1 expression .
12955726	0	chloride	59,67	CFTR	0,4	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	levels|compound|START_ENTITY patients|nmod|levels genotypes|nmod|patients genotypes|nsubj|END_ENTITY	CFTR genotypes in patients with normal or borderline sweat chloride levels .
13679192	0	chloride	58,66	CFTR	82,86	chloride	CFTR	CHEBI:17996	24255(Tax:10116)	Chemical	Gene	conductance|compound|START_ENTITY modify|dobj|conductance modify|advcl|expressing expressing|nsubj|END_ENTITY	2 - -LRB- dialkylamino -RRB- -4 H-1-benzopyran-4-one derivatives modify chloride conductance in CFTR expressing cells .
1372253	0	chloride	73,81	CFTR	26,30	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	conductance|compound|START_ENTITY restores|dobj|conductance restores|nsubj|Transfection Transfection|nmod|END_ENTITY	Transfection of wild-type CFTR into cystic_fibrosis lymphocytes restores chloride conductance at G1 of the cell cycle .
14502435	0	chloride	77,85	CFTR	72,76	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Comparative pharmacology of the activity of wild-type and G551D mutated CFTR chloride channel : effect of the benzimidazolone derivative NS004 .
14605249	0	chloride	77,85	CFTR	53,57	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	secretion|compound|START_ENTITY regulator|dep|secretion regulator|appos|END_ENTITY	Cystic_fibrosis transmembrane conductance regulator -LRB- CFTR -RRB- - mediated residual chloride secretion does not protect against early chronic Pseudomonas_aeruginosa_infection in F508del homozygous cystic fibrosis patients .
14610019	0	chloride	69,77	CFTR	64,68	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Mutation-induced blocker permeability and multiion block of the CFTR chloride channel pore .
14610041	0	chloride	119,127	CFTR	97,101	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	cells|compound|START_ENTITY channel|nmod|cells channel|amod|END_ENTITY	Influence of salinity on the localization of Na + / K + - ATPase , Na + / K + / 2Cl - _ cotransporter -LRB- NKCC -RRB- and CFTR anion channel in chloride cells of the Hawaiian goby -LRB- Stenogobius hawaiiensis -RRB- .
14729151	0	chloride	41,49	CFTR	36,40	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Beta-adrenergic receptors couple to CFTR chloride channels of intercalated mitochondria-rich cells in the heterocellular toad skin epithelium .
14744150	1	chloride	239,247	CFTR	195,199	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY functions|nmod|channel functions|nsubj|cystic_fibrosis_transmembrane_conductance_regulator cystic_fibrosis_transmembrane_conductance_regulator|appos|END_ENTITY	The cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- functions in vivo as a cAMP-activated chloride channel .
14978203	0	chloride	43,51	CFTR	38,42	chloride	CFTR	CHEBI:17996	12638(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	P2Y purinergic receptor regulation of CFTR chloride channels in mouse cardiac myocytes .
15039462	6	chloride	1005,1013	CFTR	1000,1004	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	current|compound|START_ENTITY current|amod|END_ENTITY	Iodide efflux and whole-cell patch-clamp experiments on these cells indicate a strong inhibition of CFTR chloride current by syntaxin_8 overexpression .
15130785	0	chloride	28,36	CFTR	55,59	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	conduction|compound|START_ENTITY conduction|nmod|channel channel|amod|END_ENTITY	Maximization of the rate of chloride conduction in the CFTR channel pore by ion-ion interactions .
15163550	0	chloride	110,118	CFTR	105,109	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	The cystic_fibrosis mutation G1349D within the signature motif LSHGH of NBD2 abolishes the activation of CFTR chloride channels by genistein .
15286085	0	chloride	106,114	CFTR	73,77	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	gating|nmod|START_ENTITY channel|xcomp|gating channel|nsubj|regulation regulation|appos|END_ENTITY	Novel regulation of cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- channel gating by external chloride .
15573386	0	chloride	23,31	CFTR	0,4	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|dep|channel	CFTR : more than just a chloride channel .
15573389	0	chloride	7,15	CFTR	27,31	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|nmod|transport	Beyond chloride transport : CFTR in the 21st century-introductory remarks to a new state of the art series .
15657297	0	chloride	29,37	CFTR	24,28	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Reversible silencing of CFTR chloride channels by glutathionylation .
15808474	0	chloride	99,107	CFTR	85,89	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	transport|compound|START_ENTITY mediated|dobj|transport mediated|nsubj|END_ENTITY	Discovery of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic _ acid_diamides that increase CFTR mediated chloride transport .
16432888	0	chloride	76,84	CFTR	71,75	chloride	CFTR	CHEBI:17996	373725(Tax:8355)	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Mercury toxicity in the shark -LRB- Squalus_acanthias -RRB- rectal gland : apical CFTR chloride channels are inhibited by mercuric_chloride .
16472140	0	chloride	41,49	CFTR	36,40	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY activators|nsubj|channel activators|nmod|discovery discovery|nmod|END_ENTITY	On the discovery and development of CFTR chloride channel activators .
16728467	0	chloride	114,122	CFTR	109,113	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Shark rectal gland vasoactive intestinal peptide receptor : cloning , functional expression , and regulation of CFTR chloride channels .
16762324	0	chloride	33,41	CFTR	28,32	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	function|compound|START_ENTITY function|amod|END_ENTITY	Rab27a negatively regulates CFTR chloride channel function in colonic epithelia : involvement of the effector proteins in the regulatory mechanism .
16859673	0	chloride	59,67	CFTR	53,57	chloride	CFTR	CHEBI:17996	24255(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Cystic_fibrosis_transmembrane_conductance_regulator Cystic_fibrosis_transmembrane_conductance_regulator|appos|END_ENTITY	Cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- chloride channel and Na-K-Cl cotransporter NKCC1 isoform mediate the vasorelaxant action of genistein in isolated rat aorta .
1704151	0	chloride	29,37	CFTR	64,68	chloride	CFTR	CHEBI:17996	12638(Tax:10090)	Chemical	Gene	currents|compound|START_ENTITY Generation|nmod|currents Generation|nmod|END_ENTITY	Generation of cAMP-activated chloride currents by expression of CFTR .
1712984	0	chloride	29,37	CFTR	19,23	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|nsubj|END_ENTITY	Demonstration that CFTR is a chloride channel by alteration of its anion selectivity .
1718606	0	chloride	55,63	CFTR	50,54	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Nucleoside_triphosphates are required to open the CFTR chloride channel .
17397825	0	chloride	63,71	CFTR	58,62	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Molecular mechanism of arachidonic_acid inhibition of the CFTR chloride channel .
18045536	0	chloride	52,60	CFTR	47,51	chloride	CFTR	CHEBI:17996	12638(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Spatiotemporal coupling of cAMP transporter to CFTR chloride channel function in the gut epithelia .
18306312	0	chloride	75,83	CFTR	11,15	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY behavior|nmod|channel affect|dobj|behavior affect|nsubj|variants variants|compound|END_ENTITY	N-terminal CFTR missense variants severely affect the behavior of the CFTR chloride channel .
18306312	0	chloride	75,83	CFTR	70,74	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	N-terminal CFTR missense variants severely affect the behavior of the CFTR chloride channel .
18449561	0	chloride	75,83	CFTR	70,74	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	pore|compound|START_ENTITY pore|compound|END_ENTITY	Identification of positive charges situated at the outer mouth of the CFTR chloride channel pore .
19114635	0	chloride	66,74	CFTR	39,43	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY Cd|dep|channel create|dobj|Cd create|nsubj|Mutations Mutations|nmod|sequence sequence|nmod|END_ENTITY	Mutations at the signature sequence of CFTR create a Cd -LRB- 2 + -RRB- - gated chloride channel .
19245499	0	chloride	69,77	CFTR	64,68	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Influence of salinity on the localization and expression of the CFTR chloride channel in the ionocytes of Dicentrarchus labrax during ontogeny .
19381710	0	chloride	31,39	CFTR	26,30	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	pore|compound|START_ENTITY pore|amod|END_ENTITY	Novel residues lining the CFTR chloride channel pore identified by functional modification of introduced cysteines .
19448737	0	chloride	73,81	CFTR	68,72	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Evidence that extracellular anions interact with a site outside the CFTR chloride channel pore to modify channel properties .
19466983	0	chloride	44,52	CFTR	39,43	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Cysteine-independent inhibition of the CFTR chloride channel by the cysteine-reactive reagent sodium -LRB- 2-sulphonatoethyl -RRB- _ methanethiosulphonate .
19766125	0	chloride	32,40	CFTR	54,58	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	transport|compound|START_ENTITY transport|nmod|channel channel|amod|END_ENTITY	Model of the cAMP activation of chloride transport by CFTR channel and the mechanism of potentiators .
19880323	0	chloride	79,87	CFTR	74,78	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Synthesis of 4-thiophen-2 ' - yl-1 ,4 - dihydropyridines as potentiators of the CFTR chloride channel .
19945434	0	chloride	46,54	CFTR	41,45	chloride	CFTR	CHEBI:17996	100135647(Tax:10141)	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Clustering of protein kinase A-dependent CFTR chloride channels in the sarcolemma of guinea-pig ventricular myocytes .
20142516	0	chloride	109,117	CFTR	104,108	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Regulation of conductance by the number of fixed positive charges in the intracellular vestibule of the CFTR chloride channel pore .
20225391	0	chloride	50,58	CFTR	45,49	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	A plant-derived hydrolysable tannin inhibits CFTR chloride channel : a potential treatment of diarrhea .
20363832	0	chloride	45,53	CFTR	40,44	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Cadmium regulates the expression of the CFTR chloride channel in human airway epithelial cells .
20473396	0	chloride	5,13	CFTR	0,4	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	CFTR chloride channel in the apical compartments : spatiotemporal coupling to its interacting partners .
20675434	0	chloride	27,35	CFTR	0,4	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	CFTR and calcium-activated chloride channels in primary cultures of human airway gland cells of serous or mucous phenotype .
20805575	0	chloride	58,66	CFTR	53,57	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Dual roles of the sixth transmembrane segment of the CFTR chloride channel in gating and permeation .
21548936	0	chloride	174,182	CFTR	151,155	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	secretion|compound|START_ENTITY secretion|compound|END_ENTITY	An association study on contrasting cystic_fibrosis endophenotypes recognizes KRT8 but not KRT18 as a modifier of cystic_fibrosis disease severity and CFTR mediated residual chloride secretion .
21602836	0	chloride	5,13	CFTR	0,4	chloride	CFTR	CHEBI:17996	24255(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	CFTR chloride channel as a molecular target of anthraquinone compounds in herbal laxatives .
21753184	0	chloride	26,34	CFTR	21,25	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Rescue of the mutant CFTR chloride channel by pharmacological correctors and low temperature analyzed by gene expression profiling .
21964154	0	chloride	14,22	CFTR	0,4	chloride	CFTR	CHEBI:17996	100049619(Tax:9031)	Chemical	Gene	secretion|compound|START_ENTITY mediated|dobj|secretion mediated|nsubj|END_ENTITY	CFTR mediated chloride secretion in the avian renal proximal tubule .
22467879	0	chloride	122,130	CFTR	116,120	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	channels|compound|START_ENTITY channels|amod|cystic_fibrosis_transmembrane_conductance_regulator cystic_fibrosis_transmembrane_conductance_regulator|dep|END_ENTITY	Arsenic promotes ubiquitinylation and lysosomal degradation of cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- chloride channels in human airway epithelial cells .
23376720	0	chloride	69,77	CFTR	64,68	chloride	CFTR	CHEBI:17996	100009471(Tax:9986)	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Nickel inhibits b-1 adrenoceptor mediated activation of cardiac CFTR chloride channels .
23523754	0	chloride	27,35	CFTR	102,106	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	efflux|compound|START_ENTITY efflux|appos|concentration concentration|nmod|END_ENTITY	The effect of NO-donors on chloride efflux , intracellular Ca -LRB- 2 + -RRB- concentration and mRNA expression of CFTR and ENaC in cystic_fibrosis airway epithelial cells .
23959675	0	chloride	47,55	CFTR	19,23	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY life|nmod|channel life|nmod|END_ENTITY	The secret life of CFTR as a calcium-activated chloride channel .
24147347	0	chloride	5,13	CFTR	0,4	chloride	CFTR	CHEBI:17996	12638(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	CFTR chloride channel is a molecular target of the natural cancer preventive agent resveratrol .
24204804	0	chloride	14,22	CFTR	56,60	chloride	CFTR	CHEBI:17996	12638(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY Correction|nmod|transport Correction|nmod|protein protein|amod|END_ENTITY	Correction of chloride transport and mislocalization of CFTR protein by vardenafil in the gastrointestinal tract of cystic_fibrosis mice .
24341413	0	chloride	36,44	CFTR	31,35	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Functional architecture of the CFTR chloride channel .
24660233	0	chloride	6,14	CFTR	33,37	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	START_ENTITY|nmod|biomarker biomarker|nmod|activity activity|amod|END_ENTITY	Sweat chloride as a biomarker of CFTR activity : proof of concept and ivacaftor clinical trial data .
24671572	0	chloride	51,59	CFTR	46,50	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	State-dependent blocker interactions with the CFTR chloride channel : implications for gating the pore .
24786148	0	chloride	15,23	CFTR	10,14	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	The G551D CFTR chloride channel spurs the development of personalized medicine .
24993131	0	chloride	21,29	CFTR	48,52	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	secretion|compound|START_ENTITY stimulate|dobj|secretion stimulate|nmod|END_ENTITY	Bile_acids stimulate chloride secretion through CFTR and calcium-activated Cl - channels in Calu-3 airway epithelial cells .
25367045	0	chloride	52,60	CFTR	47,51	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Conformational changes opening and closing the CFTR chloride channel : Insights from cysteine scanning mutagenesis .
25451794	0	chloride	37,45	CFTR	32,36	chloride	CFTR	CHEBI:17996	24255(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|dobj|channel	Stimulation effect of wide type CFTR chloride channel by the naturally occurring flavonoid tangeretin .
26483308	1	chloride	178,186	CFTR	312,316	chloride	CFTR	CHEBI:17996	24255(Tax:10116)	Chemical	Gene	Secretions|nmod|START_ENTITY UNASSIGNED|dep|Secretions UNASSIGNED|parataxis|involve involve|dobj|cystic_fibrosis_transmembrane_regulator cystic_fibrosis_transmembrane_regulator|appos|END_ENTITY	UNASSIGNED : Secretions of chloride -LRB- Cl -LRB- - -RRB- -RRB- - and bicarbonate -LRB- HCO3 -LRB- - -RRB- -RRB- - rich fluid by the seminal vesicles could involve cystic_fibrosis_transmembrane_regulator -LRB- CFTR -RRB- , which activity can be stimulated by cAMP generated from the reaction involving adenylate cyclase -LRB- AC -RRB- .
26659082	0	chloride	32,40	CFTR	59,63	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	ions|compound|START_ENTITY followed|nmod|ions followed|xcomp|enter enter|dobj|pore pore|amod|END_ENTITY	Cytoplasmic pathway followed by chloride ions to enter the CFTR channel pore .
26755536	0	chloride	6,14	CFTR	70,74	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	carrying|nsubj|START_ENTITY carrying|dobj|mutations mutations|compound|END_ENTITY	Sweat chloride and immunoreactive trypsinogen in infants carrying two CFTR mutations and not affected by cystic_fibrosis .
7491973	0	chloride	16,24	CFTR	8,12	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	secretion|compound|START_ENTITY Role|nmod|secretion Role|nmod|END_ENTITY	Role of CFTR in chloride secretion across human tracheal epithelium .
7508188	0	chloride	27,35	CFTR	0,4	chloride	CFTR	CHEBI:17996	12638(Tax:10090)	Chemical	Gene	currents|compound|START_ENTITY currents|amod|END_ENTITY	CFTR and calcium-activated chloride currents in pancreatic duct cells of a transgenic CF mouse .
7515570	0	chloride	94,102	CFTR	5,9	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	currents|compound|START_ENTITY contribute|nmod|currents contribute|nsubj|END_ENTITY	Both CFTR and outwardly rectifying chloride channels contribute to cAMP-stimulated whole cell chloride currents .
7521128	0	chloride	21,29	CFTR	85,89	chloride	CFTR	CHEBI:17996	373725(Tax:8355)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|dep|role role|nmod|END_ENTITY	Coupled secretion of chloride and mucus in skin of Xenopus_laevis : possible role for CFTR .
7522901	0	chloride	53,61	CFTR	48,52	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Effect of deletion mutations on the function of CFTR chloride channels .
7526932	0	chloride	65,73	CFTR	94,98	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	The cystic fibrosis mutation -LRB- delta F508 -RRB- does not influence the chloride channel activity of CFTR .
7541313	0	chloride	36,44	CFTR	0,4	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	channels|compound|START_ENTITY regulates|dobj|channels regulates|nsubj|END_ENTITY	CFTR regulates outwardly rectifying chloride channels through an autocrine mechanism involving ATP .
7573392	0	chloride	57,65	CFTR	32,36	chloride	CFTR	CHEBI:17996	100009471(Tax:9986)	Chemical	Gene	pathway|compound|START_ENTITY END_ENTITY|nmod|pathway	Rabbit pancreatic acini express CFTR as a cAMP-activated chloride efflux pathway .
7573398	0	chloride	27,35	CFTR	0,4	chloride	CFTR	CHEBI:17996	12638(Tax:10090)	Chemical	Gene	secretion|compound|START_ENTITY mediates|dobj|secretion mediates|nsubj|END_ENTITY	CFTR mediates electrogenic chloride secretion in mouse inner medullary collecting duct -LRB- mIMCD-K2 -RRB- cells .
7681632	0	chloride	16,24	CFTR	73,77	chloride	CFTR	CHEBI:17996	24255(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY nasal|nsubj|channels nasal|dep|expressing expressing|dobj|END_ENTITY	Low-conductance chloride channels in IEC-6 and CF nasal cells expressing CFTR .
7683773	0	chloride	28,36	CFTR	0,4	chloride	CFTR	CHEBI:17996	12638(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	CFTR and outward rectifying chloride channels are distinct proteins with a regulatory relationship .
7684641	0	chloride	164,172	CFTR	113,117	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	conductance|compound|START_ENTITY associated|nmod|conductance associated|nsubjpass|Expression Expression|nmod|form form|nmod|gene gene|appos|END_ENTITY	Expression of an abundant alternatively spliced form of the cystic_fibrosis transmembrane conductance regulator -LRB- CFTR -RRB- gene is not associated with a cAMP-activated chloride conductance .
7749379	0	chloride	17,25	CFTR	81,85	chloride	CFTR	CHEBI:17996	12638(Tax:10090)	Chemical	Gene	secretion|compound|START_ENTITY requires|nsubj|secretion requires|dobj|participation participation|nmod|channels channels|amod|END_ENTITY	Kinin-stimulated chloride secretion in mouse colon requires the participation of CFTR chloride channels .
7749379	0	chloride	86,94	CFTR	81,85	chloride	CFTR	CHEBI:17996	12638(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Kinin-stimulated chloride secretion in mouse colon requires the participation of CFTR chloride channels .
7757078	0	chloride	94,102	CFTR	33,37	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	activity|compound|START_ENTITY mislocalization|nmod|activity associated|nmod|mislocalization associated|nsubj|mutation mutation|nmod|gene gene|amod|END_ENTITY	Missense mutation -LRB- G480C -RRB- in the CFTR gene associated with protein mislocalization but normal chloride channel activity .
8661489	0	chloride	47,55	CFTR	42,46	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	gating|compound|START_ENTITY gating|amod|END_ENTITY	Lack of conventional ATPase properties in CFTR chloride channel gating .
8689654	0	chloride	5,13	CFTR	0,4	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	CFTR chloride channels in human and simian heart .
8759925	0	chloride	23,31	CFTR	18,22	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Regulation of the CFTR chloride channel from humans and sharks .
8770004	0	chloride	30,38	CFTR	25,29	chloride	CFTR	CHEBI:17996	100754506	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Flickery block of single CFTR chloride channels by intracellular anions and osmolytes .
8770006	0	chloride	5,13	CFTR	0,4	chloride	CFTR	CHEBI:17996	12638(Tax:10090)	Chemical	Gene	activation|compound|START_ENTITY activation|amod|END_ENTITY	CFTR chloride channel activation by genistein : the role of serine/threonine protein phosphatases .
8770056	0	chloride	31,39	CFTR	26,30	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Glibenclamide blockade of CFTR chloride channels .
8789091	1	chloride	181,189	CFTR	175,179	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY exhibits|nsubj|channel exhibits|dep|END_ENTITY	The cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- chloride channel exhibits multiple subconductance states .
8796127	0	chloride	10,18	CFTR	51,55	chloride	CFTR	CHEBI:17996	100135647(Tax:10141)	Chemical	Gene	channel|compound|START_ENTITY Effect|nmod|channel blockers|nsubj|Effect blockers|nmod|chloride chloride|compound|END_ENTITY	Effect of chloride channel blockers on the cardiac CFTR chloride and L-type calcium currents .
8997189	0	chloride	71,79	CFTR	66,70	chloride	CFTR	CHEBI:17996	373725(Tax:8355)	Chemical	Gene	conductance|compound|START_ENTITY conductance|amod|END_ENTITY	CFTR-dependent membrane insertion is linked to stimulation of the CFTR chloride conductance .
9089437	0	chloride	104,112	CFTR	98,102	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	START_ENTITY|csubj|Locating Locating|dobj|filter filter|nmod|cystic_fibrosis_transmembrane_conductance_regulator cystic_fibrosis_transmembrane_conductance_regulator|appos|END_ENTITY	Locating the anion-selectivity filter of the cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- chloride channel .
9156804	0	chloride	62,70	CFTR	33,37	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	transport|compound|START_ENTITY corrects|dobj|transport corrects|nsubj|expression expression|nmod|END_ENTITY	Episomal expression of wild-type CFTR corrects cAMP-dependent chloride transport in respiratory epithelial cells .
9196038	0	chloride	40,48	CFTR	35,39	chloride	CFTR	CHEBI:17996	100135647(Tax:10141)	Chemical	Gene	current|compound|START_ENTITY current|amod|END_ENTITY	Genistein directly induces cardiac CFTR chloride current by a tyrosine kinase-independent and protein kinase A-independent pathway in guinea_pig ventricular myocytes .
9287144	0	chloride	31,39	CFTR	135,139	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	secretion|compound|START_ENTITY Induction|nmod|secretion poorly_differentiated|nsubj|Induction poorly_differentiated|nmod|transfer transfer|compound|END_ENTITY	Induction of a cAMP-stimulated chloride secretion in regenerating poorly_differentiated airway epithelial cells by adenovirus-mediated CFTR gene transfer .
9306012	0	chloride	48,56	CFTR	124,128	chloride	CFTR	CHEBI:17996	100754506	Chemical	Gene	activation|nmod|START_ENTITY exocytosis|nmod|activation role|nmod|exocytosis conductance|nsubj|role conductance|xcomp|expressing expressing|dobj|END_ENTITY	The role of exocytosis in the activation of the chloride conductance in Chinese_hamster_ovary cells -LRB- CHO -RRB- stably expressing CFTR .
9425447	0	chloride	108,116	CFTR	19,23	chloride	CFTR	CHEBI:17996	12638(Tax:10090)	Chemical	Gene	secretion|compound|START_ENTITY restoring|dobj|secretion dose|acl|restoring effective|nmod|dose effective|nsubj|dose dose|nmod|complex complex|amod|END_ENTITY	A second dose of a CFTR cDNA-liposome complex is as effective as the first dose in restoring cAMP-dependent chloride secretion to null CF mice trachea .
9511930	0	chloride	58,66	CFTR	53,57	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Probing the structural and functional domains of the CFTR chloride channel .
9517388	0	chloride	95,103	CFTR	90,94	chloride	CFTR	CHEBI:17996	100754506	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Structural basis for specificity and potency of xanthine derivatives as activators of the CFTR chloride channel .
9569250	0	chloride	9,17	CFTR	4,8	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	The CFTR chloride channel : nucleotide interactions and temperature-dependent gating .
9575786	0	chloride	6,14	CFTR	73,77	chloride	CFTR	CHEBI:17996	12638(Tax:10090)	Chemical	Gene	currents|compound|START_ENTITY currents|dep|modulation modulation|nmod|END_ENTITY	Basal chloride currents in murine airway epithelial cells : modulation by CFTR .
9688848	0	chloride	44,52	CFTR	39,43	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Partial restoration of cAMP-stimulated CFTR chloride channel activity in DeltaF508 cells by deoxyspergualin .
9724814	0	chloride	26,34	CFTR	21,25	chloride	CFTR	CHEBI:17996	100381094(Tax:8355)	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Syntaxin 1A inhibits CFTR chloride channels by means of domain-specific protein-protein interactions .
9774978	0	chloride	13,21	CFTR	8,12	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Loss of CFTR chloride channels alters salt absorption by cystic fibrosis airway epithelia in vitro .
9922375	0	chloride	35,43	CFTR	30,34	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Structure and function of the CFTR chloride channel .
9922378	0	chloride	21,29	CFTR	16,20	chloride	CFTR	CHEBI:17996	1080	Chemical	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Pharmacology of CFTR chloride channel activity .
1334533	0	chloride	41,49	CIC-2	35,40	chloride	CIC-2	CHEBI:17996	1181	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Regions involved in the opening of CIC-2 chloride channel by voltage and cell volume .
10082675	0	chloride	25,33	CLC	116,119	chloride	CLC	CHEBI:17996	853497(Tax:4932)	Chemical	Gene	channels|compound|START_ENTITY cloning|nmod|channels END_ENTITY|nsubj|cloning	Molecular cloning of CLC chloride channels in Oreochromis_mossambicus and their functional complementation of yeast CLC gene mutant .
10082675	0	chloride	25,33	CLC	21,24	chloride	CLC	CHEBI:17996	853497(Tax:4932)	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Molecular cloning of CLC chloride channels in Oreochromis_mossambicus and their functional complementation of yeast CLC gene mutant .
11832657	0	chloride	32,40	CLC	28,31	chloride	CLC	CHEBI:17996	365395(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Gene expression profiles of CLC chloride channels in animal models with different cardiovascular_diseases .
25762128	0	chloride	37,45	CLC	33,36	chloride	CLC	CHEBI:17996	1178	Chemical	Gene	proteins|compound|START_ENTITY proteins|compound|END_ENTITY	Regulatory-auxiliary subunits of CLC chloride channel-transport proteins .
8543009	0	chloride	67,75	CLC	63,66	chloride	CLC	CHEBI:17996	1178	Chemical	Gene	family|compound|START_ENTITY family|compound|END_ENTITY	ClC-6 and ClC-7 are two novel broadly expressed members of the CLC chloride channel family .
8969232	0	chloride	21,29	CLC	112,115	chloride	CLC	CHEBI:17996	853497(Tax:4932)	Chemical	Gene	channels|compound|START_ENTITY family|nmod|channels family|nmod|yeast_strain yeast_strain|nmod|disruption disruption|compound|END_ENTITY	A family of putative chloride channels from Arabidopsis and functional complementation of a yeast_strain with a CLC gene disruption .
18391167	0	chloride	16,24	CLC-0_and_CFTR	0,14	chloride	CLC-0 and CFTR	CHEBI:17996	1080	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dep|channels	CLC-0_and_CFTR : chloride channels evolved from transporters .
16959550	0	chloride	14,22	CLC-1	8,13	chloride	CLC-1	CHEBI:17996	12723(Tax:10090)	Chemical	Gene	deficiency|compound|START_ENTITY deficiency|compound|END_ENTITY	Genetic CLC-1 chloride channel deficiency modifies diaphragm muscle isometric contractile properties .
17128287	0	chloride	23,31	CLC-1	94,99	chloride	CLC-1	CHEBI:17996	25688(Tax:10116)	Chemical	Gene	conductance|compound|START_ENTITY inhibits|dobj|conductance inhibits|nmod|inhibiting inhibiting|dobj|channel channel|compound|END_ENTITY	Niflumic_acid inhibits chloride conductance of rat skeletal muscle by directly inhibiting the CLC-1 channel and by increasing intracellular calcium .
22187529	0	chloride	57,65	CLC-1	34,39	chloride	CLC-1	CHEBI:17996	1180	Chemical	Gene	disease|compound|START_ENTITY mechanisms|nmod|disease Physiology|dep|mechanisms Physiology|nmod|END_ENTITY	Physiology and pathophysiology of CLC-1 : mechanisms of a chloride channel disease , myotonia .
23424641	0	chloride	68,76	CLC-1	62,67	chloride	CLC-1	CHEBI:17996	1180	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Myotonia_congenita mutation enhances the degradation of human CLC-1 chloride channels .
14711803	0	chloride	20,28	CLC-2	14,19	chloride	CLC-2	CHEBI:17996	29232(Tax:10116)	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Inhibition of CLC-2 chloride channel expression interrupts expansion of fetal lung_cysts .
25185546	0	chloride	72,80	CLC-2	12,17	chloride	CLC-2	CHEBI:17996	1181	Chemical	Gene	channels|compound|START_ENTITY gate|nmod|channels activates|dobj|gate activates|nsubj|GlialCAM GlialCAM|appos|subunit subunit|compound|Cl Cl|compound|END_ENTITY	GlialCAM , a CLC-2 Cl -LRB- - -RRB- channel subunit , activates the slow gate of CLC chloride channels .
26666914	0	chloride	35,43	CLC-2	29,34	chloride	CLC-2	CHEBI:17996	1181	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Gating the glutamate gate of CLC-2 chloride channel by pore occupancy .
8816717	0	chloride	75,83	CLC-2	69,74	chloride	CLC-2	CHEBI:17996	1181	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Alteration of GABAA receptor function following gene transfer of the CLC-2 chloride channel .
14754994	0	chloride	144,152	CLC-3	50,55	chloride	CLC-3	CHEBI:17996	1182	Chemical	Gene	current|compound|START_ENTITY activation|nmod|current critical|nmod|activation channel|xcomp|critical channel|nsubj|Identification Identification|nmod|amino_acid amino_acid|nmod|chloride chloride|compound|END_ENTITY	Identification of an N-terminal amino_acid of the CLC-3 chloride channel critical in phosphorylation-dependent activation of a CaMKII-activated chloride current .
18986326	0	chloride	57,65	CLC-3	51,56	chloride	CLC-3	CHEBI:17996	1182	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Cardiac-specific overexpression of the human short CLC-3 chloride channel isoform in mice .
20204734	0	chloride	6,14	CLC-3	0,5	chloride	CLC-3	CHEBI:17996	1182	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	CLC-3 chloride channels in the pulmonary vasculature .
23165767	0	chloride	6,14	CLC-3	0,5	chloride	CLC-3	CHEBI:17996	12725(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	CLC-3 chloride channels moderate long-term potentiation at Schaffer collateral-CA1 synapses .
11115837	0	chloride	19,27	CLC-5	37,42	chloride	CLC-5	CHEBI:17996	12728(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Mice lacking renal chloride channel , CLC-5 , are a model for Dent 's _ disease , a nephrolithiasis disorder associated with defective receptor-mediated endocytosis .
27044412	0	chloride	7,15	CLC-5	34,39	chloride	CLC-5	CHEBI:17996	1184	Chemical	Gene	mutant|compound|START_ENTITY mutant|nmod|END_ENTITY	A pure chloride channel mutant of CLC-5 causes Dent 's _ disease via insufficient V-ATPase activation .
8537381	0	chloride	50,58	CLC-5	41,46	chloride	CLC-5	CHEBI:17996	25749(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY related|nsubj|channel related|advcl|Cloning Cloning|dobj|expression expression|nmod|END_ENTITY	Cloning and functional expression of rat CLC-5 , a chloride channel related to kidney_disease .
9453024	0	chloride	6,14	CLC-5	0,5	chloride	CLC-5	CHEBI:17996	1184	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dep|channels	CLC-5 chloride channels and renal_disease .
16244177	0	chloride	42,50	CLC-K	36,41	chloride	CLC-K	CHEBI:17996	378616(Tax:8355)	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dobj|channels	Activation and inhibition of kidney CLC-K chloride channels by fenamates .
11143973	0	chloride	29,37	CLC-K1	22,28	chloride	CLC-K1	CHEBI:17996	1187	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Physiological role of CLC-K1 chloride channel in the kidney .
9916798	0	chloride	64,72	CLC-K1	57,63	chloride	CLC-K1	CHEBI:17996	12733(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Overt nephrogenic_diabetes_insipidus in mice lacking the CLC-K1 chloride channel .
10994760	0	chloride	18,26	CLC-K2	35,41	chloride	CLC-K2	CHEBI:17996	79430(Tax:10116)	Chemical	Gene	Overexpression|nmod|START_ENTITY channel|nsubj|Overexpression channel|dobj|mRNA mRNA|compound|END_ENTITY	Overexpression of chloride channel CLC-K2 mRNA in the renal medulla of Dahl salt-sensitive rats .
11849395	0	chloride	31,39	CLC-K2	48,54	chloride	CLC-K2	CHEBI:17996	79430(Tax:10116)	Chemical	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	Nephron specific regulation of chloride channel CLC-K2 mRNA in the rat .
10554024	0	chloride	84,92	CLCA2	101,106	chloride	CLCA2	CHEBI:17996	1181	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|nsubj|channel	Tumorigenicity of human breast_cancer is associated with loss of the Ca2 + - activated chloride channel CLCA2 .
10215406	0	chloride	81,89	CLCN1	104,109	chloride	CLCN1	CHEBI:17996	1180	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Identification of five new mutations and three novel polymorphisms in the muscle chloride channel gene -LRB- CLCN1 -RRB- in 20 Italian patients with dominant and recessive_myotonia_congenita .
10533075	0	chloride	75,83	CLCN1	98,103	chloride	CLCN1	CHEBI:17996	1180	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Identification of three novel mutations in the major human skeletal muscle chloride channel gene -LRB- CLCN1 -RRB- , causing myotonia_congenita .
10690989	0	chloride	27,35	CLCN1	50,55	chloride	CLCN1	CHEBI:17996	1180	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Functional consequences of chloride channel gene -LRB- CLCN1 -RRB- mutations causing myotonia_congenita .
15241802	0	chloride	69,77	CLCN1	63,68	chloride	CLCN1	CHEBI:17996	1180	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Characterization of three myotonia-associated mutations of the CLCN1 chloride channel gene via heterologous expression .
19697366	0	chloride	157,165	CLCN1	174,179	chloride	CLCN1	CHEBI:17996	1180	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Myotonia_congenita in a large consanguineous Arab family : insight into the clinical spectrum of carriers and double heterozygotes of a novel mutation in the chloride channel CLCN1 gene .
21385601	0	chloride	73,81	CLCN1	2,7	chloride	CLCN1	CHEBI:17996	1180	Chemical	Gene	conductance|compound|START_ENTITY increment|nmod|conductance impairs|dobj|increment impairs|nsubj|mutation mutation|compound|END_ENTITY	A CLCN1 mutation in dominant_myotonia_congenita impairs the increment of chloride conductance during repetitive depolarization .
22197188	0	chloride	43,51	CLCN1	63,68	chloride	CLCN1	CHEBI:17996	1180	Chemical	Gene	mutation|nmod|START_ENTITY channel|nsubj|mutation channel|dobj|1 1|appos|END_ENTITY	A missense mutation in the skeletal muscle chloride channel 1 -LRB- CLCN1 -RRB- as candidate causal mutation for congenital_myotonia in a New Forest pony .
23603549	0	chloride	47,55	CLCN1	70,75	chloride	CLCN1	CHEBI:17996	1180	Chemical	Gene	gene|compound|START_ENTITY mutations|nmod|gene mutations|appos|END_ENTITY	-LSB- Compound heterozygous mutations in the muscle chloride channel gene -LRB- CLCN1 -RRB- in a Japanese family with Thomsen 's _ disease -RSB- .
8533761	0	chloride	57,65	CLCN1	80,85	chloride	CLCN1	CHEBI:17996	1180	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Spectrum of mutations in the major human skeletal muscle chloride channel gene -LRB- CLCN1 -RRB- leading to myotonia .
8857733	0	chloride	39,47	CLCN1	62,67	chloride	CLCN1	CHEBI:17996	1180	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mutations in the human skeletal muscle chloride channel gene -LRB- CLCN1 -RRB- associated with dominant and recessive_myotonia_congenita .
7665160	0	chloride	90,98	CLCN3	45,50	chloride	CLCN3	CHEBI:17996	12725(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY protein|nmod|channels sharing|nmod|protein Characterization|acl|sharing Characterization|nmod|gene gene|appos|END_ENTITY	Characterization of a human and murine gene -LRB- CLCN3 -RRB- sharing similarities to voltage-gated chloride channels and to a yeast integral membrane protein .
9521585	0	chloride	42,50	CLCN3	60,65	chloride	CLCN3	CHEBI:17996	1182	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Refined localisation of the voltage-gated chloride channel , CLCN3 , to 4q33 .
10469281	0	chloride	6,14	CLCN5	24,29	chloride	CLCN5	CHEBI:17996	1184	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Renal chloride channel , CLCN5 , mutations in Dent 's _ disease .
8575751	0	chloride	56,64	CLCN5	32,37	chloride	CLCN5	CHEBI:17996	1184	Chemical	Gene	gene|compound|START_ENTITY implicated|nsubj|gene implicated|nsubj|Cloning Cloning|nmod|END_ENTITY	Cloning and characterization of CLCN5 , the human kidney chloride channel gene implicated in Dent_disease -LRB- an X-linked hereditary nephrolithiasis -RRB- .
9259268	0	chloride	26,34	CLCN5	44,49	chloride	CLCN5	CHEBI:17996	394306(Tax:8355)	Chemical	Gene	channel|compound|START_ENTITY Characterisation|nmod|channel Characterisation|appos|END_ENTITY	Characterisation of renal chloride channel , CLCN5 , mutations in hypercalciuric nephrolithiasis -LRB- kidney_stones -RRB- disorders .
9596078	0	chloride	19,27	CLCN5	13,18	chloride	CLCN5	CHEBI:17996	1184	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Mutations in CLCN5 chloride channel in Japanese patients with low molecular weight proteinuria .
9853249	0	chloride	37,45	CLCN5	55,60	chloride	CLCN5	CHEBI:17996	394306(Tax:8355)	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Functional characterization of renal chloride channel , CLCN5 , mutations associated with Dent ` sJapan_disease .
10906158	0	chloride	17,25	CLCNKB	39,45	chloride	CLCNKB	CHEBI:17996	1188	Chemical	Gene	gene|compound|START_ENTITY Mutations|nmod|gene END_ENTITY|nsubj|Mutations	Mutations in the chloride channel gene CLCNKB as a cause of classic Bartter_syndrome .
11102542	0	chloride	17,25	CLCNKB	40,46	chloride	CLCNKB	CHEBI:17996	1188	Chemical	Gene	gene|compound|START_ENTITY Mutations|nmod|gene Mutations|appos|END_ENTITY	Mutations in the chloride channel gene , CLCNKB , leading to a mixed Bartter-Gitelman_phenotype .
12472765	0	chloride	24,32	CLCNKB	47,53	chloride	CLCNKB	CHEBI:17996	1188	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A novel mutation in the chloride channel gene , CLCNKB , as a cause of Gitelman_and_Bartter_syndromes .
16391491	0	chloride	34,42	CLCNKB	57,63	chloride	CLCNKB	CHEBI:17996	1188	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A Spanish founder mutation in the chloride channel gene , CLCNKB , as a cause of atypical Bartter_syndrome in adult age .
19050915	0	chloride	112,120	CLCNKB	90,96	chloride	CLCNKB	CHEBI:17996	1188	Chemical	Gene	channel|compound|START_ENTITY coding|nmod|channel coding|nsubj|syndrome syndrome|amod|due due|nmod|mutation mutation|nmod|END_ENTITY	Chronic_renal_failure in a boy with classic Bartter 's _ syndrome due to a novel mutation in CLCNKB coding for the chloride channel .
9326936	0	chloride	17,25	CLCNKB	40,46	chloride	CLCNKB	CHEBI:17996	1188	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mutations in the chloride channel gene , CLCNKB , cause Bartter 's _ syndrome type III .
11978800	0	chloride	99,107	CLIC1	12,17	chloride	CLIC1	CHEBI:17996	100761384	Chemical	Gene	channels|compound|START_ENTITY form|dobj|channels assembles|xcomp|form assembles|nsubj|END_ENTITY	Recombinant CLIC1 -LRB- NCC27 -RRB- assembles in lipid bilayers via a pH-dependent two-state process to form chloride ion channels with identical characteristics to those observed in Chinese_hamster ovary cells expressing CLIC1 .
11978800	0	chloride	99,107	CLIC1	212,217	chloride	CLIC1	CHEBI:17996	100761384	Chemical	Gene	channels|compound|START_ENTITY form|dobj|channels form|nmod|those those|acl|observed observed|xcomp|expressing expressing|dobj|END_ENTITY	Recombinant CLIC1 -LRB- NCC27 -RRB- assembles in lipid bilayers via a pH-dependent two-state process to form chloride ion channels with identical characteristics to those observed in Chinese_hamster ovary cells expressing CLIC1 .
15190104	6	chloride	857,865	CLIC1	969,974	chloride	CLIC1	CHEBI:17996	406864(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY chloride_intracellular_channel-1|nsubj|channel chloride_intracellular_channel-1|appos|END_ENTITY	An unusual chloride ion channel known to be associated with macrophage activation is the chloride_intracellular_channel-1 -LRB- CLIC1 -RRB- .
17347778	0	chloride	10,18	CLIC1	4,9	chloride	CLIC1	CHEBI:17996	398656(Tax:8355)	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	The CLIC1 chloride channel is regulated by the cystic_fibrosis_transmembrane_conductance_regulator when expressed in Xenopus oocytes .
18028448	0	chloride	40,48	CLIC1	73,78	chloride	CLIC1	CHEBI:17996	1192	Chemical	Gene	channels|compound|START_ENTITY channels|dep|END_ENTITY	Functional reconstitution of mammalian ` chloride intracellular channels ' CLIC1 , CLIC4 and CLIC5 reveals differential regulation by cytoskeletal actin .
19387633	0	chloride	42,50	CLIC1	36,41	chloride	CLIC1	CHEBI:17996	1192	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Oxidation promotes insertion of the CLIC1 chloride intracellular channel into the membrane .
20507120	0	chloride	34,42	CLIC1	28,33	chloride	CLIC1	CHEBI:17996	1192	Chemical	Gene	intracellular|compound|START_ENTITY intracellular|compound|END_ENTITY	Metamorphic response of the CLIC1 chloride intracellular ion channel protein upon membrane interaction .
9339381	0	chloride	29,37	CLIC2	52,57	chloride	CLIC2	CHEBI:17996	1193	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genomic structure of a novel chloride channel gene , CLIC2 , in Xq28 .
12163372	0	chloride	29,37	CLIC4	66,71	chloride	CLIC4	CHEBI:17996	25932	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Differential expression of a chloride intracellular channel gene , CLIC4 , in transforming_growth_factor-beta1-mediated conversion of fibroblasts to myofibroblasts .
16358817	0	chloride	24,32	CLIC4	0,5	chloride	CLIC4	CHEBI:17996	29876(Tax:10090)	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	CLIC4 , an intracellular chloride channel protein , is a novel molecular target for cancer therapy .
16842122	0	chloride	111,119	CLIC4	136,141	chloride	CLIC4	CHEBI:17996	25932	Chemical	Gene	analysis|nmod|START_ENTITY channel|nsubj|analysis channel|dobj|END_ENTITY	Expression , purification , crystallization and preliminary crystallographic analysis of the human intracellular chloride channel protein CLIC4 .
19776349	0	chloride	29,37	CLIC4	68,73	chloride	CLIC4	CHEBI:17996	25932	Chemical	Gene	regulation|nmod|START_ENTITY intracellular|nsubj|regulation intracellular|dobj|END_ENTITY	Spatiotemporal regulation of chloride intracellular channel protein CLIC4 by RhoA .
10072771	0	chloride	64,72	CaCC	59,63	chloride	CaCC	CHEBI:17996	12722(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Characterization of a murine gene homologous to the bovine CaCC chloride channel .
26542396	0	chloride	9,17	Cftr	82,86	chloride	Cftr	CHEBI:17996	12638(Tax:10090)	Chemical	Gene	intracellular|nsubj|START_ENTITY intracellular|dobj|regulation regulation|nmod|epithelium epithelium|compound|END_ENTITY	Cellular chloride and bicarbonate retention alters intracellular pH regulation in Cftr KO crypt epithelium .
7507247	0	chloride	83,91	Cftr	130,134	chloride	Cftr	CHEBI:17996	12638(Tax:10090)	Chemical	Gene	conductance|compound|START_ENTITY conductance|dobj|conductance conductance|nmod|disease disease|nmod|mice mice|amod|END_ENTITY	Relationship of a non-cystic_fibrosis transmembrane conductance regulator-mediated chloride conductance to organ-level disease in Cftr -LRB- - / - -RRB- mice .
9558482	0	chloride	13,21	ClC	0,3	chloride	ClC	CHEBI:17996	1178	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	ClC and CFTR chloride channel gating .
10225418	0	chloride	124,132	ClC-1	36,41	chloride	ClC-1	CHEBI:17996	25688(Tax:10116)	Chemical	Gene	conductance|compound|START_ENTITY decrease|nmod|conductance relation|nmod|decrease down-regulation|dep|relation down-regulation|nmod|expression expression|compound|END_ENTITY	Aging-associated down-regulation of ClC-1 expression in skeletal muscle : phenotypic-independent relation to the decrease of chloride conductance .
10446329	0	chloride	64,72	ClC-1	83,88	chloride	ClC-1	CHEBI:17996	25688(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|dep|END_ENTITY	Single-cell RT-PCR demonstrates expression of voltage-dependent chloride channels -LRB- ClC-1 , ClC-2 and ClC-3 -RRB- in outer hair cells of rat cochlea .
11507159	0	chloride	45,53	ClC-1	39,44	chloride	ClC-1	CHEBI:17996	1180	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|dobj|channel	Temperature dependence of human muscle ClC-1 chloride channel .
12691663	0	chloride	16,24	ClC-1	84,89	chloride	ClC-1	CHEBI:17996	1180	Chemical	Gene	structure|compound|START_ENTITY Conservation|nmod|structure revealed|nsubj|Conservation revealed|nmod|site site|nmod|END_ENTITY	Conservation of chloride channel structure revealed by an inhibitor binding site in ClC-1 .
16002443	0	chloride	33,41	ClC-1	20,25	chloride	ClC-1	CHEBI:17996	1180	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Zinc inhibits human ClC-1 muscle chloride channel by interacting with its common gating mechanism .
16027167	0	chloride	73,81	ClC-1	67,72	chloride	ClC-1	CHEBI:17996	1180	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Cytoplasmic ATP-sensing domains regulate gating of skeletal muscle ClC-1 chloride channels .
18008009	0	chloride	40,48	ClC-1	14,19	chloride	ClC-1	CHEBI:17996	12723(Tax:10090)	Chemical	Gene	channelopathy|compound|START_ENTITY eliminates|dobj|channelopathy eliminates|nsubj|Correction Correction|nmod|splicing splicing|compound|END_ENTITY	Correction of ClC-1 splicing eliminates chloride channelopathy and myotonia in mouse models of myotonic_dystrophy .
19220292	0	chloride	47,55	ClC-1	101,106	chloride	ClC-1	CHEBI:17996	25688(Tax:10116)	Chemical	Gene	conductance|compound|START_ENTITY affect|dobj|conductance affect|advcl|impairing impairing|dobj|regulation regulation|compound|END_ENTITY	Statins and fenofibrate affect skeletal muscle chloride conductance in rats by differently impairing ClC-1 channel regulation and expression .
22641783	0	chloride	71,79	ClC-1	65,70	chloride	ClC-1	CHEBI:17996	1180	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Disease-causing mutations C277R and C277Y modify gating of human ClC-1 chloride channels in myotonia_congenita .
22689570	0	chloride	85,93	ClC-1	79,84	chloride	ClC-1	CHEBI:17996	1180	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Intracellular b-nicotinamide_adenine_dinucleotide inhibits the skeletal muscle ClC-1 chloride channel .
8130334	0	chloride	60,68	ClC-1	78,83	chloride	ClC-1	CHEBI:17996	1180	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Low single channel conductance of the major skeletal muscle chloride channel , ClC-1 .
9468477	0	chloride	67,75	ClC-1	85,90	chloride	ClC-1	CHEBI:17996	25688(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Relevance of the D13 region to the function of the skeletal muscle chloride channel , ClC-1 .
9565403	0	chloride	44,52	ClC-1	62,67	chloride	ClC-1	CHEBI:17996	25688(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Permeation and block of the skeletal muscle chloride channel , ClC-1 , by foreign anions .
10446329	0	chloride	64,72	ClC-2	90,95	chloride	ClC-2	CHEBI:17996	29232(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|dep|ClC-1 ClC-1|appos|END_ENTITY	Single-cell RT-PCR demonstrates expression of voltage-dependent chloride channels -LRB- ClC-1 , ClC-2 and ClC-3 -RRB- in outer hair cells of rat cochlea .
11045957	0	chloride	43,51	ClC-2	62,67	chloride	ClC-2	CHEBI:17996	100135500(Tax:10141)	Chemical	Gene	channels|compound|START_ENTITY distribution|nmod|channels distribution|dep|END_ENTITY	Molecular distribution of volume-regulated chloride channels -LRB- ClC-2 and ClC-3 -RRB- in cardiac tissues .
11096079	0	chloride	28,36	ClC-2	0,5	chloride	ClC-2	CHEBI:17996	1181	Chemical	Gene	secretion|compound|START_ENTITY contributes|nmod|secretion contributes|nsubj|END_ENTITY	ClC-2 contributes to native chloride secretion by a human intestinal cell line , Caco-2 .
12916350	0	chloride	16,24	ClC-2	33,38	chloride	ClC-2	CHEBI:17996	1181	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	-LSB- Expressions of chloride channel ClC-2 and ClC-3 in human nasal_polyps -RSB- .
15213059	0	chloride	75,83	ClC-2	69,74	chloride	ClC-2	CHEBI:17996	1181	Chemical	Gene	currents|compound|START_ENTITY currents|compound|END_ENTITY	SPI-0211 activates T84 cell chloride transport and recombinant human ClC-2 chloride currents .
16155254	0	chloride	41,49	ClC-2	35,40	chloride	ClC-2	CHEBI:17996	397147(Tax:9823)	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Basolateral localization of native ClC-2 chloride channels in absorptive intestinal epithelial cells and basolateral sorting encoded by a CBS-2 domain di-leucine motif .
17334850	0	chloride	35,43	ClC-2	18,23	chloride	ClC-2	CHEBI:17996	29232(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Identification of ClC-2 and CIC-K2 chloride channels in cultured rat type IV spiral ligament fibrocytes .
18801843	0	chloride	22,30	ClC-2	16,21	chloride	ClC-2	CHEBI:17996	1181	Chemical	Gene	START_ENTITY|nsubj|Gating Gating|nmod|END_ENTITY	Gating of human ClC-2 chloride channels and regulation by carboxy-terminal domains .
20357128	0	chloride	86,94	ClC-2	0,5	chloride	ClC-2	CHEBI:17996	12724(Tax:10090)	Chemical	Gene	extrusion|compound|START_ENTITY conductance|dobj|extrusion constitute|ccomp|conductance constitute|nsubj|channels channels|amod|END_ENTITY	ClC-2 voltage-gated channels constitute part of the background conductance and assist chloride extrusion .
22049427	0	chloride	65,73	ClC-2	0,5	chloride	ClC-2	CHEBI:17996	29232(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY intracellular|dobj|levels regulate|dep|intracellular regulate|nsubj|channels channels|amod|END_ENTITY	ClC-2 channels regulate neuronal excitability , not intracellular chloride levels .
9321672	0	chloride	50,58	ClC-2	132,137	chloride	ClC-2	CHEBI:17996	29232(Tax:10116)	Chemical	Gene	gene|compound|START_ENTITY variants|nmod|gene expressed|nsubjpass|variants expressed|nmod|lung lung|dep|sequence sequence|nmod|END_ENTITY	Alternative mRNA splice variants of the rat ClC-2 chloride channel gene are expressed in lung : genomic sequence and organization of ClC-2 .
9321672	0	chloride	50,58	ClC-2	44,49	chloride	ClC-2	CHEBI:17996	29232(Tax:10116)	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Alternative mRNA splice variants of the rat ClC-2 chloride channel gene are expressed in lung : genomic sequence and organization of ClC-2 .
9449697	0	chloride	51,59	ClC-2	40,45	chloride	ClC-2	CHEBI:17996	1181	Chemical	Gene	ClC-3|compound|START_ENTITY END_ENTITY|appos|ClC-3	The swelling-activated chloride channel ClC-2 , the chloride channel ClC-3 , _ and_ClC-5 , a chloride channel mutated in kidney_stone_disease , are expressed in distinct subpopulations of renal epithelial cells .
9449697	0	chloride	88,96	ClC-2	40,45	chloride	ClC-2	CHEBI:17996	1181	Chemical	Gene	channel|compound|START_ENTITY ClC-3|appos|channel END_ENTITY|appos|ClC-3	The swelling-activated chloride channel ClC-2 , the chloride channel ClC-3 , _ and_ClC-5 , a chloride channel mutated in kidney_stone_disease , are expressed in distinct subpopulations of renal epithelial cells .
9520461	0	chloride	57,65	ClC-2	12,17	chloride	ClC-2	CHEBI:17996	1181	Chemical	Gene	conduction|compound|START_ENTITY pathway|nmod|conduction Analysis|nmod|pathway Analysis|nmod|channels channels|compound|END_ENTITY	Analysis of ClC-2 channels as an alternative pathway for chloride conduction in cystic_fibrosis airway cells .
10973952	0	chloride	73,81	ClC-3	26,31	chloride	ClC-3	CHEBI:17996	84360(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY differentiate|nmod|channels differentiate|nsubj|properties properties|nmod|END_ENTITY	Biophysical properties of ClC-3 differentiate it from swelling-activated chloride channels in Chinese_hamster ovary-K1 cells .
11182090	0	chloride	23,31	ClC-3	14,19	chloride	ClC-3	CHEBI:17996	12725(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY expressed|nsubj|channel leads|parataxis|expressed leads|nsubj|Disruption Disruption|nmod|END_ENTITY	Disruption of ClC-3 , a chloride channel expressed on synaptic vesicles , leads to a loss of the hippocampus .
11278960	0	chloride	42,50	ClC-3	6,11	chloride	ClC-3	CHEBI:17996	1182	Chemical	Gene	channel|compound|START_ENTITY channel|nsubj|END_ENTITY	Human ClC-3 is not the swelling-activated chloride channel involved in cell volume regulation .
12470859	0	chloride	100,108	ClC-3	80,85	chloride	ClC-3	CHEBI:17996	12725(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Altered GABAergic function accompanies hippocampal_degeneration in mice lacking ClC-3 voltage-gated chloride channels .
18923035	0	chloride	22,30	ClC-3	43,48	chloride	ClC-3	CHEBI:17996	12725(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY Role|nmod|transporter END_ENTITY|nsubj|Role	Role of the vesicular chloride transporter ClC-3 in neuroendocrine tissue .
19615374	0	chloride	83,91	ClC-3	28,33	chloride	ClC-3	CHEBI:17996	12725(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY eliminates|dobj|channels eliminates|nsubj|deletion deletion|compound|END_ENTITY	Cardiac-specific , inducible ClC-3 gene deletion eliminates native volume-sensitive chloride channels and produces myocardial_hypertrophy in adult mice .
21115901	0	chloride	56,64	ClC-3	84,89	chloride	ClC-3	CHEBI:17996	1182	Chemical	Gene	channels|compound|START_ENTITY channels|nmod|END_ENTITY	Invasion of human glioma cells is regulated by multiple chloride channels including ClC-3 .
21792908	0	chloride	40,48	ClC-3	0,5	chloride	ClC-3	CHEBI:17996	1182	Chemical	Gene	channels|compound|START_ENTITY component|nmod|channels component|nsubj|END_ENTITY	ClC-3 is a main component of background chloride channels activated under isotonic conditions by autocrine ATP in nasopharyngeal_carcinoma cells .
22496242	0	chloride	70,78	ClC-3	0,5	chloride	ClC-3	CHEBI:17996	1182	Chemical	Gene	currents|compound|START_ENTITY mediating|dobj|currents proteins|acl|mediating candidate|nmod|proteins candidate|nsubj|END_ENTITY	ClC-3 is a candidate of the channel proteins mediating acid-activated chloride currents in nasopharyngeal_carcinoma cells .
9449697	0	chloride	23,31	ClC-3	68,73	chloride	ClC-3	CHEBI:17996	1182	Chemical	Gene	ClC-2|compound|START_ENTITY ClC-2|appos|END_ENTITY	The swelling-activated chloride channel ClC-2 , the chloride channel ClC-3 , _ and_ClC-5 , a chloride channel mutated in kidney_stone_disease , are expressed in distinct subpopulations of renal epithelial cells .
9449697	0	chloride	88,96	ClC-3	68,73	chloride	ClC-3	CHEBI:17996	1182	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|appos|channel	The swelling-activated chloride channel ClC-2 , the chloride channel ClC-3 , _ and_ClC-5 , a chloride channel mutated in kidney_stone_disease , are expressed in distinct subpopulations of renal epithelial cells .
9874688	0	chloride	69,77	ClC-3	20,25	chloride	ClC-3	CHEBI:17996	1182	Chemical	Gene	regulation|compound|START_ENTITY phosphorylation-dephosphorylation|nmod|regulation links|xcomp|phosphorylation-dephosphorylation links|nsubj|residue residue|nmod|END_ENTITY	A serine residue in ClC-3 links phosphorylation-dephosphorylation to chloride channel regulation by cell volume .
11882671	0	chloride	55,63	ClC-4	49,54	chloride	ClC-4	CHEBI:17996	1183	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Functional characterization of recombinant human ClC-4 chloride channels in cultured mammalian cells .
17023393	0	chloride	45,53	ClC-4	10,15	chloride	ClC-4	CHEBI:17996	1183	Chemical	Gene	family|compound|START_ENTITY member|nmod|family protein|appos|member protein|compound|END_ENTITY	The human ClC-4 protein , a member of the CLC chloride channel/transporter family , is localized to the endoplasmic reticulum by its N-terminus .
11839544	0	chloride	34,42	ClC-5	0,5	chloride	ClC-5	CHEBI:17996	25749(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY ontogeny|nmod|channel END_ENTITY|dep|ontogeny	ClC-5 : ontogeny of an alternative chloride channel in respiratory epithelia .
12815097	0	chloride	8,16	ClC-5	25,30	chloride	ClC-5	CHEBI:17996	12728(Tax:10090)	Chemical	Gene	impairs|compound|START_ENTITY impairs|compound|END_ENTITY	Loss of chloride channel ClC-5 impairs endocytosis by defective trafficking of megalin and cubilin in kidney proximal tubules .
13679301	0	chloride	68,76	ClC-5	43,48	chloride	ClC-5	CHEBI:17996	1184	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|nmod|channel	Coexpression of complementary fragments of ClC-5 and restoration of chloride channel function in a Dent 's _ disease mutation .
16226913	0	chloride	9,17	ClC-5	0,5	chloride	ClC-5	CHEBI:17996	1184	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|dep|channel	ClC-5 : a chloride channel with multiple roles in renal tubular albumin uptake .
16306076	0	chloride	16,24	ClC-5	34,39	chloride	ClC-5	CHEBI:17996	12728(Tax:10090)	Chemical	Gene	iodide|compound|START_ENTITY iodide|dep|END_ENTITY	The loss of the chloride channel , ClC-5 , delays apical iodide efflux and induces a euthyroid_goiter in the mouse thyroid gland .
9653142	0	chloride	11,19	ClC-5	0,5	chloride	ClC-5	CHEBI:17996	1184	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|appos|channel	ClC-5 , the chloride channel mutated in Dent 's _ disease , colocalizes with the proton pump in endocytotically active kidney cells .
10925178	0	chloride	42,50	ClC-K1	35,41	chloride	ClC-K1	CHEBI:17996	79425(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	mRNA expression of kidney-specific ClC-K1 chloride channel in single-cell reverse transcription-polymerase chain reaction analysis of outer hair cells of rat cochlea .
7814604	0	chloride	68,76	ClC-K1	86,92	chloride	ClC-K1	CHEBI:17996	79425(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Localization and functional characterization of rat kidney-specific chloride channel , ClC-K1 .
17767918	0	chloride	57,65	ClC-K2	50,56	chloride	ClC-K2	CHEBI:17996	1188	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Barttin binds to the outer lateral surface of the ClC-K2 chloride channel .
15148291	0	chloride	44,52	ClC-Kb	61,67	chloride	ClC-Kb	CHEBI:17996	378616(Tax:8355)	Chemical	Gene	channel|compound|START_ENTITY mutation|nmod|channel END_ENTITY|nsubj|mutation	Activating mutation of the renal epithelial chloride channel ClC-Kb predisposing to hypertension .
19904698	0	chloride	32,40	ClCN7	49,54	chloride	ClCN7	CHEBI:17996	1186	Chemical	Gene	due|nmod|START_ENTITY END_ENTITY|amod|due	Osteopetrosis due to homozygous chloride channel ClCN7 mutation mimicking metabolic_disease with haematological_and_neurological_impairment .
20921420	0	chloride	29,37	Claudin-4	0,9	chloride	Claudin-4	CHEBI:17996	12740(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY forms|dobj|channel forms|nsubj|END_ENTITY	Claudin-4 forms paracellular chloride channel in the kidney and requires claudin-8 for tight junction localization .
8119941	0	chloride	48,56	Clc-1	70,75	chloride	Clc-1	CHEBI:17996	12723(Tax:10090)	Chemical	Gene	mutations|nmod|START_ENTITY channel|nsubj|mutations channel|dobj|END_ENTITY	Nonsense and missense mutations in the muscular chloride channel gene Clc-1 of myotonic mice .
10191357	0	chloride	117,125	Cystic_fibrosis_transmembrane_conductance_regulator	0,51	chloride	Cystic fibrosis transmembrane conductance regulator	CHEBI:17996	12638(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY confers|nmod|channel confers|nsubj|END_ENTITY	Cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- confers glibenclamide sensitivity to outwardly rectifying chloride channel -LRB- ORCC -RRB- in Hi-5 insect cells .
11071305	0	chloride	126,134	Cystic_fibrosis_transmembrane_conductance_regulator	0,51	chloride	Cystic fibrosis transmembrane conductance regulator	CHEBI:17996	1080	Chemical	Gene	channels|compound|START_ENTITY relationship|nmod|channels END_ENTITY|dep|relationship	Cystic_fibrosis_transmembrane_conductance_regulator and the outwardly rectifying chloride channel : a relationship between two chloride channels expressed in epithelial cells .
17700963	0	chloride	55,63	Cystic_fibrosis_transmembrane_conductance_regulator	0,51	chloride	Cystic fibrosis transmembrane conductance regulator	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|dep|channel	Cystic_fibrosis_transmembrane_conductance_regulator : a chloride channel gated by ATP binding and hydrolysis .
21308994	0	chloride	71,79	Cystic_fibrosis_transmembrane_conductance_regulator	0,51	chloride	Cystic fibrosis transmembrane conductance regulator	CHEBI:17996	24255(Tax:10116)	Chemical	Gene	homeostasis|compound|START_ENTITY modulates|dobj|homeostasis modulates|nsubj|END_ENTITY	Cystic_fibrosis_transmembrane_conductance_regulator modulates synaptic chloride homeostasis in motoneurons of the rat spinal cord during neonatal development .
24600512	0	chloride	52,60	Cystic_fibrosis_transmembrane_conductance_regulator	0,51	chloride	Cystic fibrosis transmembrane conductance regulator	CHEBI:17996	1080	Chemical	Gene	blockers|compound|START_ENTITY blockers|amod|END_ENTITY	Cystic_fibrosis_transmembrane_conductance_regulator chloride channel blockers : Pharmacological , biophysical and physiological relevance .
12651923	0	chloride	43,51	DRA	79,82	chloride	DRA	CHEBI:17996	1811	Chemical	Gene	exchanger|compound|START_ENTITY exchanger|appos|END_ENTITY	Acute regulation of the SLC26A3 congenital chloride diarrhoea anion exchanger -LRB- DRA -RRB- expressed in Xenopus oocytes .
16288863	0	chloride	135,143	DeltaF508-cystic_fibrosis_transmembrane_conductance_regulator	73,134	chloride	DeltaF508-cystic fibrosis transmembrane conductance regulator	CHEBI:17996	1080	Chemical	Gene	gating|compound|START_ENTITY gating|compound|END_ENTITY	Sulfamoyl-4-oxoquinoline-3-carboxamides : novel potentiators of defective DeltaF508-cystic_fibrosis_transmembrane_conductance_regulator chloride channel gating .
9174061	0	chloride	52,60	EAAT4	0,5	chloride	EAAT4	CHEBI:17996	84012(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY properties|nmod|channel glutamate_transporter|nmod|properties END_ENTITY|appos|glutamate_transporter	EAAT4 , a glutamate_transporter with properties of a chloride channel , is predominantly localized in Purkinje cell dendrites , and forms parasagittal compartments in rat cerebellum .
9570792	0	chloride	84,92	EAAT4	26,31	chloride	EAAT4	CHEBI:17996	84012(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|dep|channel	The glutamate transporter EAAT4 in rat cerebellar Purkinje cells : a glutamate-gated chloride channel concentrated near the synapse in parts of the dendritic membrane facing astroglia .
1326745	0	chloride	24,32	Endothelin-1	0,12	chloride	Endothelin-1	CHEBI:17996	100009270(Tax:9986)	Chemical	Gene	secretion|compound|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Endothelin-1 stimulates chloride and potassium secretion in rabbit descending colon .
1332155	0	chloride	24,32	Endothelin-1	0,12	chloride	Endothelin-1	CHEBI:17996	1906	Chemical	Gene	secretion|compound|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Endothelin-1 stimulates chloride secretion across canine tracheal epithelium .
9080369	0	chloride	33,41	Endothelin-1	0,12	chloride	Endothelin-1	CHEBI:17996	1906	Chemical	Gene	secretion|compound|START_ENTITY secretion|amod|END_ENTITY	Endothelin-1 potently stimulates chloride secretion and inhibits Na -LRB- + -RRB- - glucose absorption in human intestine in vitro .
17325549	0	chloride	35,43	Epidermal_growth_factor	0,23	chloride	Epidermal growth factor	CHEBI:17996	100008808(Tax:9986)	Chemical	Gene	transport|compound|START_ENTITY stimulates|dobj|transport stimulates|nsubj|END_ENTITY	Epidermal_growth_factor stimulates chloride transport in primary cultures of weanling and adult rabbit colonocytes .
9811853	0	chloride	132,140	Fet3p	88,93	chloride	Fet3p	CHEBI:17996	855080(Tax:4932)	Chemical	Gene	channels|compound|START_ENTITY channels|dep|END_ENTITY	Chloride is an allosteric effector of copper assembly for the yeast multicopper oxidase Fet3p : an unexpected role for intracellular chloride channels .
8054658	0	chloride	50,58	GABA_receptor	36,49	chloride	GABA receptor	CHEBI:17996	39054(Tax:7227)	Chemical	Gene	complex|compound|START_ENTITY complex|compound|END_ENTITY	Cyclodiene resistance at the insect GABA_receptor / chloride channel complex confers broad cross resistance to convulsants and experimental phenylpyrazole insecticides .
9702060	0	chloride	15,23	GABA_receptor	1,14	chloride	GABA receptor	CHEBI:17996	11337	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	-LSB- GABA_receptor chloride ion channel -RSB- .
11842292	0	chloride	20,28	HCLCA1	38,44	chloride	HCLCA1	CHEBI:17996	1179	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	A calcium-activated chloride channel -LRB- HCLCA1 -RRB- is strongly related to IL-9 expression and mucus production in bronchial epithelium of patients with asthma .
3059825	0	chloride	31,39	Insulin	0,7	chloride	Insulin	CHEBI:17996	3630	Chemical	Gene	reabsorption|compound|START_ENTITY increases|dobj|reabsorption increases|nsubj|END_ENTITY	Insulin increases loop segment chloride reabsorption in the euglycemic rat .
11286023	0	chloride	48,56	Interferon-gamma	0,16	chloride	Interferon-gamma	CHEBI:17996	3458	Chemical	Gene	channels|compound|START_ENTITY activates|dobj|channels activates|nsubj|END_ENTITY	Interferon-gamma activates outwardly rectifying chloride channels in the human bronchial epithelial cell line BEAS-2B .
11117534	0	chloride	51,59	Janus_kinase_2	0,14	chloride	Janus kinase 2	CHEBI:17996	3717	Chemical	Gene	transport|compound|START_ENTITY regulates|dobj|transport regulates|nsubj|END_ENTITY	Janus_kinase_2 -LRB- JAK2 -RRB- regulates prolactin-mediated chloride transport in mouse mammary epithelial cells through tyrosine phosphorylation of Na + - K + -2 Cl - _ cotransporter .
17598093	0	chloride	43,51	KCC1	67,71	chloride	KCC1	CHEBI:17996	29501(Tax:10116)	Chemical	Gene	cotransporter|compound|START_ENTITY cotransporter|appos|END_ENTITY	Amino_acid transporter -LRB- VIAAT , VGLUT2 -RRB- and chloride cotransporter -LRB- KCC1 , KCC2 and NKCC1 -RRB- expression in the vestibular nuclei of intact and labyrinthectomized rat .
15469961	0	chloride	83,91	KCC2	25,29	chloride	KCC2	CHEBI:17996	57138(Tax:10090)	Chemical	Gene	regulation|nmod|START_ENTITY show|dobj|regulation show|nsubj|neurons neurons|acl|lacking lacking|dobj|expression expression|compound|END_ENTITY	Cortical neurons lacking KCC2 expression show impaired regulation of intracellular chloride .
17598093	0	chloride	43,51	KCC2	73,77	chloride	KCC2	CHEBI:17996	171373(Tax:10116)	Chemical	Gene	cotransporter|compound|START_ENTITY cotransporter|appos|KCC1 KCC1|dep|END_ENTITY	Amino_acid transporter -LRB- VIAAT , VGLUT2 -RRB- and chloride cotransporter -LRB- KCC1 , KCC2 and NKCC1 -RRB- expression in the vestibular nuclei of intact and labyrinthectomized rat .
21486764	0	chloride	77,85	KCC2	21,25	chloride	KCC2	CHEBI:17996	171373(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY increases|dobj|concentration increases|csubj|Knocking Knocking|nmod|END_ENTITY	Knocking down of the KCC2 in rat hippocampal neurons increases intracellular chloride concentration and compromises neuronal survival .
23226777	0	chloride	29,37	KCC2	68,72	chloride	KCC2	CHEBI:17996	57468	Chemical	Gene	expression|nmod|START_ENTITY Changes|nmod|expression Changes|amod|homeostasis-regulating homeostasis-regulating|dep|genes genes|nummod|END_ENTITY	Changes in expression of the chloride homeostasis-regulating genes , KCC2 and NKCC1 , in the blood of cirrhotic patients with hepatic_encephalopathy .
23229576	0	chloride	67,75	KCC2	168,172	chloride	KCC2	CHEBI:17996	57138(Tax:10090)	Chemical	Gene	extrusion|compound|START_ENTITY accelerates|dobj|extrusion accelerates|nmod|expression expression|nmod|END_ENTITY	Highly conductive carbon nanotube matrix accelerates developmental chloride extrusion in central nervous system neurons by increased expression of chloride transporter KCC2 .
26239662	0	chloride	74,82	KCC2	96,100	chloride	KCC2	CHEBI:17996	57138(Tax:10090)	Chemical	Gene	alterations|nmod|START_ENTITY transporters|nsubj|alterations transporters|dep|associated associated|nsubj|END_ENTITY	Repeated_stress-induced expression pattern alterations of the hippocampal chloride transporters KCC2 and NKCC1 associated with behavioral_abnormalities in female mice .
25831548	0	chloride	29,37	KLHL3	0,5	chloride	KLHL3	CHEBI:17996	100503085	Chemical	Gene	transport|compound|START_ENTITY regulates|dobj|transport regulates|nsubj|END_ENTITY	KLHL3 regulates paracellular chloride transport in the kidney by ubiquitination of claudin-8 .
19923298	0	chloride	94,102	Kcc2	20,24	chloride	Kcc2	CHEBI:17996	57468	Chemical	Gene	switch|nmod|START_ENTITY controls|dobj|switch controls|nsubj|repression repression|nmod|transcription transcription|amod|END_ENTITY	Novel repression of Kcc2 transcription by REST-RE-1 controls developmental switch in neuronal chloride .
23440186	0	chloride	33,41	Kcc2	97,101	chloride	Kcc2	CHEBI:17996	57468	Chemical	Gene	shift|compound|START_ENTITY delays|dobj|shift delays|nmod|effects effects|nmod|promoter promoter|amod|END_ENTITY	Bisphenol_A delays the perinatal chloride shift in cortical neurons by epigenetic effects on the Kcc2 promoter .
26254230	0	chloride	28,36	LRRC8A	8,14	chloride	LRRC8A	CHEBI:17996	56262	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dep|channels	TMEM16 , LRRC8A , bestrophin : chloride channels controlled by Ca -LRB- 2 + -RRB- and cell volume .
11100728	0	chloride	27,35	MOD-1	0,5	chloride	MOD-1	CHEBI:17996	179269(Tax:6239)	Chemical	Gene	channel|compound|START_ENTITY channel|nsubj|END_ENTITY	MOD-1 is a serotonin-gated chloride channel that modulates locomotory behaviour in C. _ elegans .
2084451	0	chloride	6,14	Milk	1,5	chloride	Milk	CHEBI:17996	100532204	Chemical	Gene	level|compound|START_ENTITY level|compound|END_ENTITY	-LSB- Milk chloride level as an indicator of bovine mastitis -RSB- .
19464362	0	chloride	48,56	Myeloperoxidase	0,15	chloride	Myeloperoxidase	CHEBI:17996	4353	Chemical	Gene	deficiency|compound|START_ENTITY interaction|dep|deficiency interaction|amod|END_ENTITY	Myeloperoxidase interaction with peroxynitrite : chloride deficiency and heme depletion .
11692276	0	chloride	42,50	NKCC1	64,69	chloride	NKCC1	CHEBI:17996	20496(Tax:10090)	Chemical	Gene	cotransport|dep|START_ENTITY Expression|nmod|cotransport Expression|appos|END_ENTITY	Expression and role of sodium , potassium , chloride cotransport -LRB- NKCC1 -RRB- in mouse inner medullary collecting duct -LRB- mIMCD-K2 -RRB- epithelial cells .
15678112	0	chloride	16,24	NKCC1	38,43	chloride	NKCC1	CHEBI:17996	20496(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Na -LRB- + -RRB- - dependent chloride transporter -LRB- NKCC1 -RRB- - null mice exhibit less gray and white_matter_damage after focal cerebral_ischemia .
16319203	0	chloride	9,17	NKCC1	71,76	chloride	NKCC1	CHEBI:17996	20496(Tax:10090)	Chemical	Gene	accumulation|compound|START_ENTITY accumulation|acl|lacking lacking|dobj|END_ENTITY	Neuronal chloride accumulation in olfactory epithelium of mice lacking NKCC1 .
16859673	0	chloride	59,67	NKCC1	102,107	chloride	NKCC1	CHEBI:17996	83629(Tax:10116)	Chemical	Gene	START_ENTITY|ccomp|mediate mediate|nsubj|isoform isoform|compound|END_ENTITY	Cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- chloride channel and Na-K-Cl cotransporter NKCC1 isoform mediate the vasorelaxant action of genistein in isolated rat aorta .
17355320	0	chloride	23,31	NKCC1	48,53	chloride	NKCC1	CHEBI:17996	83629(Tax:10116)	Chemical	Gene	cotransporters|compound|START_ENTITY differences|nmod|cotransporters differences|appos|END_ENTITY	Sex differences in the chloride cotransporters , NKCC1 and KCC2 , in the developing hypothalamus .
19036864	0	chloride	35,43	NKCC1	0,5	chloride	NKCC1	CHEBI:17996	6558	Chemical	Gene	accumulate|dobj|START_ENTITY appear|xcomp|accumulate appear|nsubj|END_ENTITY	NKCC1 and AE3 appear to accumulate chloride in embryonic_motoneurons .
19103648	0	chloride	74,82	NKCC1	65,70	chloride	NKCC1	CHEBI:17996	83629(Tax:10116)	Chemical	Gene	handling|compound|START_ENTITY END_ENTITY|nmod|handling	Differential contribution of the Na -LRB- + -RRB- - K -LRB- + -RRB- -2 Cl -LRB- - -RRB- cotransporter NKCC1 to chloride handling in rat embryonic dorsal root ganglion neurons and motor neurons .
20732874	0	chloride	57,65	NKCC1	155,160	chloride	NKCC1	CHEBI:17996	6558	Chemical	Gene	response|compound|START_ENTITY inhibit|dobj|response PKC|acl:relcl|inhibit PKC|dep|Cl Cl|dep|END_ENTITY	Activated PKC -LCB- delta -RCB- _ and_PKC -LCB- epsilon -RCB- inhibit epithelial chloride secretion response to cAMP via inducing internalization of the Na + - K + -2 Cl - cotransporter NKCC1 .
20819979	0	chloride	49,57	NKCC1	71,76	chloride	NKCC1	CHEBI:17996	6558	Chemical	Gene	regulators|nmod|START_ENTITY expression|nmod|regulators transporters|nsubj|expression transporters|dobj|END_ENTITY	Altered expression of regulators of the cortical chloride transporters NKCC1 and KCC2 in schizophrenia .
22723696	0	chloride	28,36	NKCC1	0,5	chloride	NKCC1	CHEBI:17996	6558	Chemical	Gene	homeostasis|compound|START_ENTITY disrupts|dobj|homeostasis disrupts|nsubj|upregulation upregulation|compound|END_ENTITY	NKCC1 upregulation disrupts chloride homeostasis in the hypothalamus and increases neuronal activity-sympathetic drive in hypertension .
1380091	0	chloride	47,55	NPPB	112,116	chloride	NPPB	CHEBI:17996	4879	Chemical	Gene	channel|compound|START_ENTITY gating|nmod|channel Modification|acl|gating Modification|dep|benzoic_acid benzoic_acid|appos|END_ENTITY	Modification of gating of an airway epithelial chloride channel by 5-nitro-2 - -LRB- 3-phenylpropylamino -RRB- benzoic_acid -LRB- NPPB -RRB- .
16268500	0	chloride	23,31	NPPB	49,53	chloride	NPPB	CHEBI:17996	4879	Chemical	Gene	channel|compound|START_ENTITY effects|nmod|channel blockers|nsubj|effects blockers|dobj|END_ENTITY	-LSB- Inhibitory effects of chloride channel blockers NPPB on proliferation of human glomerular mesangial cells -RSB- .
1652470	0	chloride	4,12	NPPB	76,80	chloride	NPPB	CHEBI:17996	4879	Chemical	Gene	channel|compound|START_ENTITY blocker|nsubj|channel blocker|parataxis|uncouples uncouples|nsubj|benzoic_acid benzoic_acid|appos|END_ENTITY	The chloride channel blocker 5-nitro-2 - -LRB- 3-phenylpropyl-amino -RRB- _ benzoic_acid -LRB- NPPB -RRB- uncouples mitochondria and increases the proton permeability of the plasma membrane in phagocytic cells .
1720331	0	chloride	65,73	NPPB	11,15	chloride	NPPB	CHEBI:17996	103352511	Chemical	Gene	transport|compound|START_ENTITY Effects|nmod|transport Effects|nmod|END_ENTITY	Effects of NPPB -LRB- 5-nitro-2 - -LRB- 3-phenylpropylamino -RRB- benzoic_acid -RRB- on chloride transport in intestinal tissues and the T84 cell line .
18775743	0	chloride	82,90	NPPB	73,77	chloride	NPPB	CHEBI:17996	25105(Tax:10116)	Chemical	Gene	blocker|compound|START_ENTITY benzoic_acid|appos|blocker benzoic_acid|appos|END_ENTITY	Increased hyperalgesia by 5-nitro-2 , _ 3 - -LRB- phenylpropylamino -RRB- - benzoic_acid -LRB- NPPB -RRB- , a chloride channel blocker in crush_injury-induced neuropathic_pain in rats .
10790147	0	chloride	31,39	P-glycoprotein	52,66	chloride	P-glycoprotein	CHEBI:17996	5243	Chemical	Gene	channels|compound|START_ENTITY Regulation|nmod|channels Regulation|nmod|END_ENTITY	Regulation of volume-activated chloride channels by P-glycoprotein : phosphorylation has the final say !
9729520	0	chloride	43,51	Peptide_YY	0,10	chloride	Peptide YY	CHEBI:17996	217212(Tax:10090)	Chemical	Gene	secretion|compound|START_ENTITY inhibits|dobj|secretion inhibits|nsubj|END_ENTITY	Peptide_YY inhibits vasopressin-stimulated chloride secretion in inner medullary collecting duct cells .
2012204	0	chloride	78,86	Renin	0,5	chloride	Renin	CHEBI:17996	100358545(Tax:9986)	Chemical	Gene	transport|compound|START_ENTITY depends|nmod|transport depends|nsubj|release release|compound|END_ENTITY	Renin release from isolated juxtaglomerular apparatus depends on macula densa chloride transport .
3901779	0	chloride	34,42	Renin	0,5	chloride	Renin	CHEBI:17996	24715(Tax:10116)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Renin secretion and loop of Henle chloride reabsorption in the adrenalectomized rat .
8184893	0	chloride	72,80	Renin	0,5	chloride	Renin	CHEBI:17996	24715(Tax:10116)	Chemical	Gene	stimulated|nmod|START_ENTITY stimulated|nsubjpass|release release|compound|END_ENTITY	Renin release from permeabilized juxtaglomerular cells is stimulated by chloride but not by low calcium .
21716257	0	chloride	12,20	Slc26a11	0,8	chloride	Slc26a11	CHEBI:17996	284129	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|appos|transporter	Slc26a11 , a chloride transporter , localizes with the vacuolar H -LRB- + -RRB- - ATPase of A-intercalated cells of the kidney .
24810589	0	chloride	8,16	Slc26a7	0,7	chloride	Slc26a7	CHEBI:17996	208890(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Slc26a7 chloride channel activity and localization in mouse Reissner 's membrane epithelium .
18724360	0	chloride	53,61	TMEM16A	0,7	chloride	TMEM16A	CHEBI:17996	101772(Tax:10090)	Chemical	Gene	conductance|compound|START_ENTITY confers|dobj|conductance confers|nsubj|END_ENTITY	TMEM16A confers receptor-activated calcium-dependent chloride conductance .
18772398	0	chloride	62,70	TMEM16A	0,7	chloride	TMEM16A	CHEBI:17996	55107	Chemical	Gene	activity|compound|START_ENTITY associated|nmod|activity protein|acl|associated END_ENTITY|appos|protein	TMEM16A , a membrane protein associated with calcium-dependent chloride channel activity .
18805094	0	chloride	53,61	TMEM16A	22,29	chloride	TMEM16A	CHEBI:17996	55107	Chemical	Gene	subunit|compound|START_ENTITY cloning|nmod|subunit cloning|nmod|END_ENTITY	Expression cloning of TMEM16A as a calcium-activated chloride channel subunit .
19654323	0	chloride	41,49	TMEM16A	92,99	chloride	TMEM16A	CHEBI:17996	101772(Tax:10090)	Chemical	Gene	currents|compound|START_ENTITY currents|acl:relcl|reduced reduced|nmod|mice mice|acl|lacking lacking|dobj|END_ENTITY	TMEM16 proteins produce volume-regulated chloride currents that are reduced in mice lacking TMEM16A .
19679661	0	chloride	61,69	TMEM16A	8,15	chloride	TMEM16A	CHEBI:17996	101772(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY defect|dep|transport causes|dobj|defect causes|nsubj|Loss Loss|nmod|END_ENTITY	Loss of TMEM16A causes a defect in epithelial Ca2 + - dependent chloride transport .
20974900	0	chloride	66,74	TMEM16A	0,7	chloride	TMEM16A	CHEBI:17996	55107	Chemical	Gene	channels|compound|START_ENTITY architecture|nmod|channels /|dobj|architecture /|nsubj|END_ENTITY	TMEM16A -LRB- a -RRB- / anoctamin-1 shares a homodimeric architecture with CLC chloride channels .
21115851	0	chloride	68,76	TMEM16A	85,92	chloride	TMEM16A	CHEBI:17996	101772(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY activation|nmod|channel END_ENTITY|nsubj|activation	Calmodulin-dependent activation of the epithelial calcium-dependent chloride channel TMEM16A .
21645494	0	chloride	57,65	TMEM16A	25,32	chloride	TMEM16A	CHEBI:17996	55107	Chemical	Gene	activity|compound|START_ENTITY associated|nmod|activity associated|nsubj|isoform isoform|nmod|protein protein|compound|END_ENTITY	A minimal isoform of the TMEM16A protein associated with chloride channel activity .
21836025	0	chloride	58,66	TMEM16A	29,36	chloride	TMEM16A	CHEBI:17996	55107	Chemical	Gene	channel|compound|START_ENTITY activators|appos|channel activators|nmod|END_ENTITY	Small-molecule activators of TMEM16A , a calcium-activated chloride channel , stimulate epithelial chloride secretion and intestinal contraction .
21836025	0	chloride	97,105	TMEM16A	29,36	chloride	TMEM16A	CHEBI:17996	55107	Chemical	Gene	secretion|compound|START_ENTITY stimulate|dobj|secretion stimulate|nsubj|activators activators|nmod|END_ENTITY	Small-molecule activators of TMEM16A , a calcium-activated chloride channel , stimulate epithelial chloride secretion and intestinal contraction .
21984732	0	chloride	63,71	TMEM16A	22,29	chloride	TMEM16A	CHEBI:17996	55107	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|nmod|channels	The anoctamin family : TMEM16A and TMEM16B as calcium-activated chloride channels .
22215857	0	chloride	44,52	TMEM16A	18,25	chloride	TMEM16A	CHEBI:17996	309135(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Downregulation of TMEM16A calcium-activated chloride channel contributes to cerebrovascular_remodeling during hypertension by promoting basilar smooth muscle cell proliferation .
22988141	0	chloride	23,31	TMEM16A	15,22	chloride	TMEM16A	CHEBI:17996	55107	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Association of TMEM16A chloride channel overexpression with airway goblet cell metaplasia .
23996050	0	chloride	52,60	TMEM16A	26,33	chloride	TMEM16A	CHEBI:17996	55107	Chemical	Gene	channels|compound|START_ENTITY channels|nummod|END_ENTITY	Divalent cations modulate TMEM16A calcium-activated chloride channels by a common mechanism .
24420770	0	chloride	33,41	TMEM16A	24,31	chloride	TMEM16A	CHEBI:17996	55107	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Activation of the Ano1 -LRB- TMEM16A -RRB- chloride channel by calcium is not mediated by calmodulin .
24448969	0	chloride	76,84	TMEM16A	107,114	chloride	TMEM16A	CHEBI:17996	55107	Chemical	Gene	modulators|compound|START_ENTITY modulators|nmod|END_ENTITY	Development and validation of HTS assay for screening the calcium-activated chloride channel modulators in TMEM16A stably expressed CHO cells .
24489780	0	chloride	55,63	TMEM16A	29,36	chloride	TMEM16A	CHEBI:17996	55107	Chemical	Gene	channels|compound|START_ENTITY channels|nummod|END_ENTITY	Activation and inhibition of TMEM16A calcium-activated chloride channels .
24704530	0	chloride	12,20	TMEM16A	4,11	chloride	TMEM16A	CHEBI:17996	55107	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	The TMEM16A chloride channel as an alternative therapeutic target in cystic fibrosis .
25220078	0	chloride	96,104	TMEM16A	8,15	chloride	TMEM16A	CHEBI:17996	55107	Chemical	Gene	secretion|compound|START_ENTITY contributes|nmod|secretion contributes|nsubj|variant variant|compound|END_ENTITY	A novel TMEM16A splice variant lacking the dimerization domain contributes to calcium-activated chloride secretion in human sweat gland epithelial cells .
25781344	0	chloride	62,70	TMEM16A	25,32	chloride	TMEM16A	CHEBI:17996	55107	Chemical	Gene	currents|compound|START_ENTITY END_ENTITY|dep|currents	Secreted CLCA1 modulates TMEM16A to activate Ca -LRB- 2 + -RRB- - dependent chloride currents in human cells .
25853341	0	chloride	69,77	TMEM16A	43,50	chloride	TMEM16A	CHEBI:17996	100170550(Tax:8364)	Chemical	Gene	channels|compound|START_ENTITY channels|nummod|END_ENTITY	Study of permeation and blocker binding in TMEM16A calcium-activated chloride channels .
26181339	2	chloride	277,285	TMEM16A	251,258	chloride	TMEM16A	CHEBI:17996	55107	Chemical	Gene	channel|compound|START_ENTITY channel|nummod|END_ENTITY	The TMEM16A calcium-activated chloride channel modulates airway_smooth_muscle -LRB- ASM -RRB- contraction .
26181339	2	chloride	277,285	TMEM16A	251,258	chloride	TMEM16A	CHEBI:17996	55107	Chemical	Gene	channel|compound|START_ENTITY channel|nummod|END_ENTITY	The TMEM16A calcium-activated chloride channel modulates airway_smooth_muscle -LRB- ASM -RRB- contraction .
25899321	0	chloride	34,42	TRPC1	0,5	chloride	TRPC1	CHEBI:17996	7220	Chemical	Gene	channels|compound|START_ENTITY regulates|dobj|channels regulates|nsubj|END_ENTITY	TRPC1 regulates calcium-activated chloride channels in salivary gland cells .
22685202	0	chloride	37,45	Tmem16A	13,20	chloride	Tmem16A	CHEBI:17996	100190795(Tax:8355)	Chemical	Gene	channel|compound|START_ENTITY interacts|nsubj|channel +|parataxis|interacts +|nsubj|Ca2 Ca2|appos|END_ENTITY	Anoctamin_1 -LRB- Tmem16A -RRB- Ca2 + - activated chloride channel stoichiometrically interacts with an ezrin-radixin-moesin network .
21976594	0	chloride	82,90	Tmem16a	114,121	chloride	Tmem16a	CHEBI:17996	101772(Tax:10090)	Chemical	Gene	conductance|compound|START_ENTITY conductance|acl|encoded encoded|nmod|END_ENTITY	Electrical slow waves in the mouse oviduct are dependent upon a calcium activated chloride conductance encoded by Tmem16a .
19169251	0	chloride	2,10	VGLUT1	26,32	chloride	VGLUT1	CHEBI:17996	57030	Chemical	Gene	conductance|compound|START_ENTITY conductance|nmod|END_ENTITY	A chloride conductance in VGLUT1 underlies maximal glutamate loading into synaptic vesicles .
1978256	0	chloride	2,10	aminopeptidase	29,43	chloride	aminopeptidase	CHEBI:17996	10404	Chemical	Gene	activated|nsubj|START_ENTITY activated|dobj|END_ENTITY	A chloride activated alanine aminopeptidase from a melanoma cell line .
1649762	0	chloride	111,119	angiotensin-converting_enzyme	30,59	chloride	angiotensin-converting enzyme	CHEBI:17996	24310(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY membranes|dep|effect membranes|amod|binding binding|nmod|END_ENTITY	-LSB- 3H -RSB- ramiprilat binding to the angiotensin-converting_enzyme in rat renal brush-border membranes : the effect of chloride .
23672666	0	chloride	72,80	angiotensin-converting_enzyme	23,52	chloride	angiotensin-converting enzyme	CHEBI:17996	1636	Chemical	Gene	ion|compound|START_ENTITY mechanism|nmod|ion mechanism|nmod|END_ENTITY	Catalytic mechanism of angiotensin-converting_enzyme and effects of the chloride ion .
2846041	0	chloride	272,280	angiotensin-converting_enzyme	47,76	chloride	angiotensin-converting enzyme	CHEBI:17996	1636	Chemical	Gene	concentration|compound|START_ENTITY function|nmod|concentration examined|nmod|function examined|nsubjpass|Catalysis Catalysis|nmod|hydrolysis hydrolysis|nmod|END_ENTITY	Catalysis of angiotensin_I hydrolysis by human angiotensin-converting_enzyme : effect of chloride and pH. The catalysis of the hydrolysis of angiotensin_I , an important natural substrate , by human angiotensin-converting_enzyme -LRB- ACE -RRB- was examined in detail as a function of chloride and hydrogen ion concentration .
2846041	0	chloride	88,96	angiotensin-converting_enzyme	47,76	chloride	angiotensin-converting enzyme	CHEBI:17996	1636	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|dep|effect	Catalysis of angiotensin_I hydrolysis by human angiotensin-converting_enzyme : effect of chloride and pH. The catalysis of the hydrolysis of angiotensin_I , an important natural substrate , by human angiotensin-converting_enzyme -LRB- ACE -RRB- was examined in detail as a function of chloride and hydrogen ion concentration .
6320729	0	chloride	8,16	angiotensin-converting_enzyme	51,80	chloride	angiotensin-converting enzyme	CHEBI:17996	1636	Chemical	Gene	ion|compound|START_ENTITY Role|nmod|ion Role|nmod|activator activator|nmod|END_ENTITY	Role of chloride ion as an allosteric activator of angiotensin-converting_enzyme .
2551273	0	chloride	139,147	angiotensin_I-converting_enzyme	47,78	chloride	angiotensin I-converting enzyme	CHEBI:17996	1636	Chemical	Gene	role|nmod|START_ENTITY Evidence|dep|role Evidence|nmod|site site|nmod|END_ENTITY	Evidence for a single active site in the human angiotensin_I-converting_enzyme from inhibitor binding studies with -LSB- 3H -RSB- _ RU_44_403 : role of chloride .
7904922	0	chloride	10,18	angiotensin_I-converting_enzyme	40,71	chloride	angiotensin I-converting enzyme	CHEBI:17996	1636	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	Effect of chloride and diamide on serum angiotensin_I-converting_enzyme activity from eight mammalian species .
11353695	0	chloride	8,16	angiotensin_II	61,75	chloride	angiotensin II	CHEBI:17996	183	Chemical	Gene	Role|nmod|START_ENTITY Role|acl|descending descending|nmod|END_ENTITY	Role of chloride in constriction of descending vasa recta by angiotensin_II .
14506073	0	chloride	11,19	angiotensin_II	72,86	chloride	angiotensin II	CHEBI:17996	24179(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY Effects|nmod|channel blockers|nsubj|Effects blockers|nmod|END_ENTITY	Effects of chloride channel blockers on rat renal vascular responses to angiotensin_II and norepinephrine .
1873017	0	chloride	14,22	angiotensin_II	58,72	chloride	angiotensin II	CHEBI:17996	24179(Tax:10116)	Chemical	Gene	Importance|nmod|START_ENTITY Importance|nmod|development development|nmod|hypertension hypertension|compound|END_ENTITY	Importance of chloride in the development of salt-induced angiotensin_II hypertension in rats .
20147605	0	chloride	63,71	angiotensin_II	100,114	chloride	angiotensin II	CHEBI:17996	24179(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY catecholamines|nmod|transport Effect|nmod|catecholamines Effect|dep|interaction interaction|nmod|END_ENTITY	Effect of catecholamines on rat medullary thick ascending limb chloride transport : interaction with angiotensin_II .
2059912	0	chloride	10,18	angiotensin_II	42,56	chloride	angiotensin II	CHEBI:17996	24179(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY flow|nsubj|Effect flow|nmod|END_ENTITY	Effect of chloride on renal blood flow in angiotensin_II induced hypertension .
7734105	0	chloride	27,35	angiotensin_II	102,116	chloride	angiotensin II	CHEBI:17996	24179(Tax:10116)	Chemical	Gene	blockade|compound|START_ENTITY effect|nmod|blockade contractile|nsubj|effect contractile|nmod|END_ENTITY	Segment-specific effect of chloride channel blockade on rat renal arteriolar contractile responses to angiotensin_II .
2820467	0	chloride	28,36	angiotensin_converting_enzyme	51,80	chloride	angiotensin converting enzyme	CHEBI:17996	1636	Chemical	Gene	activation|compound|START_ENTITY potentiation|nmod|activation potentiation|nmod|END_ENTITY	Sulfate potentiation of the chloride activation of angiotensin_converting_enzyme .
6095894	0	chloride	59,67	angiotensin_converting_enzyme	14,43	chloride	angiotensin converting enzyme	CHEBI:17996	1636	Chemical	Gene	dependence|nmod|START_ENTITY Inhibition|dep|dependence Inhibition|nmod|END_ENTITY	Inhibition of angiotensin_converting_enzyme : dependence on chloride .
6317019	0	chloride	31,39	angiotensin_converting_enzyme	56,85	chloride	angiotensin converting enzyme	CHEBI:17996	1636	Chemical	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Critical lysine residue at the chloride binding site of angiotensin_converting_enzyme .
9536650	0	chloride	10,18	angiotensin_converting_enzyme	34,63	chloride	angiotensin converting enzyme	CHEBI:17996	554335(Tax:9940)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of chloride and diamide on angiotensin_converting_enzyme from sheep testis and epididymis .
24481603	0	chloride	56,64	anoctamin_1	26,37	chloride	anoctamin 1	CHEBI:17996	101772(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Computational modeling of anoctamin_1 calcium-activated chloride channels as pacemaker channels in interstitial cells of Cajal .
11004208	0	chloride	48,56	atrial_natriuretic_peptide	18,44	chloride	atrial natriuretic peptide	CHEBI:17996	230899(Tax:10090)	Chemical	Gene	reabsorption|compound|START_ENTITY END_ENTITY|nmod|reabsorption	Effect of luminal atrial_natriuretic_peptide on chloride reabsorption in mouse cortical thick ascending limb : inhibition by endothelin .
24341532	0	chloride	82,90	bestrophin-1	51,63	chloride	bestrophin-1	CHEBI:17996	7439	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Effects of alternative splicing on the function of bestrophin-1 calcium-activated chloride channels .
15452198	0	chloride	94,102	bestrophin-2	81,93	chloride	bestrophin-2	CHEBI:17996	212989(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Determinants of anion permeation in the second transmembrane domain of the mouse bestrophin-2 chloride channel .
19622610	0	chloride	18,26	bestrophin-2	83,95	chloride	bestrophin-2	CHEBI:17996	212989(Tax:10090)	Chemical	Gene	currents|compound|START_ENTITY currents|acl|lacking lacking|xcomp|END_ENTITY	Calcium-activated chloride currents in olfactory sensory neurons from mice lacking bestrophin-2 .
21659661	0	chloride	85,93	bone_morphogenetic_protein-2	20,48	chloride	bone morphogenetic protein-2	CHEBI:17996	650	Chemical	Gene	currents|compound|START_ENTITY currents|amod|END_ENTITY	Opposing effects of bone_morphogenetic_protein-2 and endothelin-1 on lung fibroblast chloride currents .
10491143	0	chloride	33,41	cathepsin_C	60,71	chloride	cathepsin C	CHEBI:17996	1075	Chemical	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Location of the binding site for chloride ion activation of cathepsin_C .
10610763	0	chloride	23,31	clh-1	14,19	chloride	clh-1	CHEBI:17996	174821(Tax:6239)	Chemical	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	Disruption of clh-1 , a chloride channel gene , results in a wider body of Caenorhabditis_elegans .
10974021	0	chloride	93,101	cyclooxygenase-2	48,64	chloride	cyclooxygenase-2	CHEBI:17996	29527(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Role of p38 in the regulation of renal cortical cyclooxygenase-2 expression by extracellular chloride .
10075649	0	chloride	30,38	cystic_fibrosis_transmembrane_conductance_regulator	58,109	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	1080	Chemical	Gene	ions|compound|START_ENTITY pore|nmod|ions formed|nsubj|pore formed|nmod|molecules molecules|compound|END_ENTITY	A single conductance pore for chloride ions formed by two cystic_fibrosis_transmembrane_conductance_regulator molecules .
10102935	0	chloride	62,70	cystic_fibrosis_transmembrane_conductance_regulator	10,61	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	12638(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Gating of cystic_fibrosis_transmembrane_conductance_regulator chloride channels by adenosine_triphosphate hydrolysis .
10217542	0	chloride	117,125	cystic_fibrosis_transmembrane_conductance_regulator	65,116	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Substrates of multidrug resistance-associated proteins block the cystic_fibrosis_transmembrane_conductance_regulator chloride channel .
10220340	0	chloride	111,119	cystic_fibrosis_transmembrane_conductance_regulator	59,110	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Arg352 is a major determinant of charge selectivity in the cystic_fibrosis_transmembrane_conductance_regulator chloride channel .
10788432	0	chloride	88,96	cystic_fibrosis_transmembrane_conductance_regulator	36,87	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	373725(Tax:8355)	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Epithelial sodium channels regulate cystic_fibrosis_transmembrane_conductance_regulator chloride channels in Xenopus oocytes .
10827976	0	chloride	103,111	cystic_fibrosis_transmembrane_conductance_regulator	51,102	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Molecular determinants of anion selectivity in the cystic_fibrosis_transmembrane_conductance_regulator chloride channel pore .
10914639	0	chloride	66,74	cystic_fibrosis_transmembrane_conductance_regulator	14,65	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	1080	Chemical	Gene	currents|compound|START_ENTITY currents|compound|END_ENTITY	Inhibition of cystic_fibrosis_transmembrane_conductance_regulator chloride channel currents by arachidonic_acid .
11179391	0	chloride	145,153	cystic_fibrosis_transmembrane_conductance_regulator	93,144	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	1080	Chemical	Gene	pore|compound|START_ENTITY pore|compound|END_ENTITY	Relationship between anion binding and anion permeability revealed by mutagenesis within the cystic_fibrosis_transmembrane_conductance_regulator chloride channel pore .
11380256	0	chloride	80,88	cystic_fibrosis_transmembrane_conductance_regulator	28,79	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	1080	Chemical	Gene	pore|compound|START_ENTITY pore|compound|END_ENTITY	Asymmetric structure of the cystic_fibrosis_transmembrane_conductance_regulator chloride channel pore suggested by mutagenesis of the twelfth transmembrane region .
11675385	0	chloride	4,12	cystic_fibrosis_transmembrane_conductance_regulator	45,96	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	1080	Chemical	Gene	ClC-4|compound|START_ENTITY co-localizes|nsubj|ClC-4 co-localizes|nmod|END_ENTITY	The chloride channel ClC-4 co-localizes with cystic_fibrosis_transmembrane_conductance_regulator and may mediate chloride flux across the apical membrane of intestinal epithelia .
1281220	0	chloride	101,109	cystic_fibrosis_transmembrane_conductance_regulator	49,100	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	1080	Chemical	Gene	currents|compound|START_ENTITY currents|compound|END_ENTITY	Effect of ATP-sensitive K + channel regulators on cystic_fibrosis_transmembrane_conductance_regulator chloride currents .
1370301	0	chloride	71,79	cystic_fibrosis_transmembrane_conductance_regulator	16,67	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	1080	Chemical	Gene	epithelia|compound|START_ENTITY Localization|nmod|epithelia Localization|nmod|END_ENTITY	Localization of cystic_fibrosis_transmembrane_conductance_regulator in chloride secretory epithelia .
1374403	0	chloride	102,110	cystic_fibrosis_transmembrane_conductance_regulator	50,101	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	12638(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Cyclic_AMP-dependent protein kinase activation of cystic_fibrosis_transmembrane_conductance_regulator chloride channels in planar lipid bilayers .
1379720	0	chloride	140,148	cystic_fibrosis_transmembrane_conductance_regulator	39,90	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	1080	Chemical	Gene	currents|compound|START_ENTITY inhibit|dobj|currents inhibit|nsubj|oligodeoxynucleotides oligodeoxynucleotides|nmod|END_ENTITY	Antisense oligodeoxynucleotides to the cystic_fibrosis_transmembrane_conductance_regulator inhibit cAMP-activated but not calcium-activated chloride currents .
15286085	0	chloride	106,114	cystic_fibrosis_transmembrane_conductance_regulator	20,71	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	1080	Chemical	Gene	gating|nmod|START_ENTITY channel|xcomp|gating channel|nsubj|regulation regulation|nmod|END_ENTITY	Novel regulation of cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- channel gating by external chloride .
15289377	0	chloride	77,85	cystic_fibrosis_transmembrane_conductance_regulator	25,76	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	12638(Tax:10090)	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Targeted inactivation of cystic_fibrosis_transmembrane_conductance_regulator chloride channel gene prevents ischemic preconditioning in isolated mouse heart .
15504721	0	chloride	143,151	cystic_fibrosis_transmembrane_conductance_regulator	91,142	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	1080	Chemical	Gene	pore|compound|START_ENTITY pore|compound|END_ENTITY	Direct comparison of the functional roles played by different transmembrane regions in the cystic_fibrosis_transmembrane_conductance_regulator chloride channel pore .
15504728	0	chloride	96,104	cystic_fibrosis_transmembrane_conductance_regulator	44,95	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Determination of the functional unit of the cystic_fibrosis_transmembrane_conductance_regulator chloride channel .
15634668	0	chloride	132,140	cystic_fibrosis_transmembrane_conductance_regulator	80,131	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Location of a common inhibitor binding site in the cytoplasmic vestibule of the cystic_fibrosis_transmembrane_conductance_regulator chloride channel pore .
16157656	0	chloride	13,21	cystic_fibrosis_transmembrane_conductance_regulator	40,91	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	1080	Chemical	Gene	permeation|compound|START_ENTITY Mechanism|nmod|permeation Mechanism|nmod|channel channel|compound|END_ENTITY	Mechanism of chloride permeation in the cystic_fibrosis_transmembrane_conductance_regulator chloride channel .
16157656	0	chloride	92,100	cystic_fibrosis_transmembrane_conductance_regulator	40,91	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Mechanism of chloride permeation in the cystic_fibrosis_transmembrane_conductance_regulator chloride channel .
16794779	0	chloride	105,113	cystic_fibrosis_transmembrane_conductance_regulator	53,104	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	1080	Chemical	Gene	pore|compound|START_ENTITY pore|compound|END_ENTITY	Interactions between impermeant blocking ions in the cystic_fibrosis_transmembrane_conductance_regulator chloride channel pore : evidence for anion-induced conformational changes .
16829626	0	chloride	171,179	cystic_fibrosis_transmembrane_conductance_regulator	119,170	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	1080	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Discovery of pyrrolo -LSB- 2,3-b -RSB- pyrazines derivatives as submicromolar affinity activators of wild type , G551D , and F508del cystic_fibrosis_transmembrane_conductance_regulator chloride channels .
1715567	0	chloride	15,23	cystic_fibrosis_transmembrane_conductance_regulator	90,141	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	1080	Chemical	Gene	conductance|nsubj|START_ENTITY conductance|xcomp|expressing expressing|dobj|END_ENTITY	cAMP-inducible chloride conductance in mouse fibroblast lines stably expressing the human cystic_fibrosis_transmembrane_conductance_regulator .
17293558	0	chloride	132,140	cystic_fibrosis_transmembrane_conductance_regulator	80,131	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Identification of a second blocker binding site at the cytoplasmic mouth of the cystic_fibrosis_transmembrane_conductance_regulator chloride channel pore .
17347778	0	chloride	10,18	cystic_fibrosis_transmembrane_conductance_regulator	47,98	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	373725(Tax:8355)	Chemical	Gene	channel|compound|START_ENTITY regulated|nsubjpass|channel regulated|nmod|END_ENTITY	The CLIC1 chloride channel is regulated by the cystic_fibrosis_transmembrane_conductance_regulator when expressed in Xenopus oocytes .
17477025	0	chloride	87,95	cystic_fibrosis_transmembrane_conductance_regulator	35,86	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	1080	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dobj|channels	Expression and function of CLC_and cystic_fibrosis_transmembrane_conductance_regulator chloride channels in renal epithelial tubule cells : pathophysiological implications .
17673962	0	chloride	119,127	cystic_fibrosis_transmembrane_conductance_regulator	67,118	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Direct and indirect effects of mutations at the outer mouth of the cystic_fibrosis_transmembrane_conductance_regulator chloride channel pore .
18167343	0	chloride	92,100	cystic_fibrosis_transmembrane_conductance_regulator	40,91	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	State-dependent access of anions to the cystic_fibrosis_transmembrane_conductance_regulator chloride channel pore .
18272811	0	chloride	116,124	cystic_fibrosis_transmembrane_conductance_regulator	64,115	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	1080	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Alpha-aminoazaheterocyclic-methylglyoxal adducts do not inhibit cystic_fibrosis_transmembrane_conductance_regulator chloride channel activity .
18723516	0	chloride	94,102	cystic_fibrosis_transmembrane_conductance_regulator	42,93	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Three-dimensional reconstruction of human cystic_fibrosis_transmembrane_conductance_regulator chloride channel revealed an ellipsoidal structure with orifices beneath the putative transmembrane domain .
19491324	0	chloride	94,102	cystic_fibrosis_transmembrane_conductance_regulator	42,93	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Mutation-specific potency and efficacy of cystic_fibrosis_transmembrane_conductance_regulator chloride channel potentiators .
20110677	0	chloride	136,144	cystic_fibrosis_transmembrane_conductance_regulator	58,109	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	1080	Chemical	Gene	closing|compound|START_ENTITY required|nmod|closing required|nsubjpass|H-loop H-loop|nmod|domain domain|nmod|END_ENTITY	The H-loop in the second nucleotide-binding domain of the cystic_fibrosis_transmembrane_conductance_regulator is required for efficient chloride channel closing .
20231442	0	chloride	90,98	cystic_fibrosis_transmembrane_conductance_regulator	6,57	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	12638(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY cAMP-PKA-regulated|dobj|channels cAMP-PKA-regulated|nsubj|forms forms|compound|END_ENTITY	Mouse cystic_fibrosis_transmembrane_conductance_regulator forms cAMP-PKA-regulated apical chloride channels in cortical collecting duct .
20351096	0	chloride	106,114	cystic_fibrosis_transmembrane_conductance_regulator	54,105	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	12638(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Alpha-AP-2 directs myosin_VI-dependent endocytosis of cystic_fibrosis_transmembrane_conductance_regulator chloride channels in the intestine .
20675380	0	chloride	149,157	cystic_fibrosis_transmembrane_conductance_regulator	97,148	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Changes in accessibility of cytoplasmic substances to the pore associated with activation of the cystic_fibrosis_transmembrane_conductance_regulator chloride channel .
21746847	0	chloride	94,102	cystic_fibrosis_transmembrane_conductance_regulator	42,93	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Alignment of transmembrane regions in the cystic_fibrosis_transmembrane_conductance_regulator chloride channel pore .
22467879	0	chloride	122,130	cystic_fibrosis_transmembrane_conductance_regulator	63,114	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	1080	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Arsenic promotes ubiquitinylation and lysosomal degradation of cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- chloride channels in human airway epithelial cells .
22545782	0	chloride	144,152	cystic_fibrosis_transmembrane_conductance_regulator	92,143	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Role of the juxtamembrane region of cytoplasmic loop 3 in the gating and conductance of the cystic_fibrosis_transmembrane_conductance_regulator chloride channel .
23984517	0	chloride	91,99	cystic_fibrosis_transmembrane_conductance_regulator	39,90	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	1080	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- The activation effect of nobiletin on cystic_fibrosis_transmembrane_conductance_regulator chloride channel -RSB- .
25253636	0	chloride	125,133	cystic_fibrosis_transmembrane_conductance_regulator	73,124	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Interaction between 2 extracellular loops influences the activity of the cystic_fibrosis_transmembrane_conductance_regulator chloride channel .
25673337	0	chloride	101,109	cystic_fibrosis_transmembrane_conductance_regulator	49,100	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Location of a permeant anion binding site in the cystic_fibrosis_transmembrane_conductance_regulator chloride channel pore .
25896054	0	chloride	90,98	cystic_fibrosis_transmembrane_conductance_regulator	38,89	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	24255(Tax:10116)	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Polymethoxylated_flavonoids activate cystic_fibrosis_transmembrane_conductance_regulator chloride channel -RSB- .
7493947	0	chloride	96,104	cystic_fibrosis_transmembrane_conductance_regulator	20,71	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	281067(Tax:9913)	Chemical	Gene	channels|compound|START_ENTITY rectified|dobj|channels rectified|nsubj|Interaction Interaction|nmod|END_ENTITY	Interaction between cystic_fibrosis_transmembrane_conductance_regulator and outwardly rectified chloride channels .
7499295	0	chloride	143,151	cystic_fibrosis_transmembrane_conductance_regulator	62,113	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	1080	Chemical	Gene	state|compound|START_ENTITY regulation|nmod|state involved|nmod|regulation involved|nsubjpass|loop loop|nmod|END_ENTITY	Intracellular loop between transmembrane segments IV and V of cystic_fibrosis_transmembrane_conductance_regulator is involved in regulation of chloride channel conductance state .
7508815	0	chloride	44,52	cystic_fibrosis_transmembrane_conductance_regulator	96,147	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	1080	Chemical	Gene	START_ENTITY|nmod|fibroblasts fibroblasts|acl|expressing expressing|dobj|END_ENTITY	Activation of Cl - currents by intracellular chloride in fibroblasts stably expressing the human cystic_fibrosis_transmembrane_conductance_regulator .
7510684	0	chloride	98,106	cystic_fibrosis_transmembrane_conductance_regulator	46,97	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	1080	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Biochemical and biophysical identification of cystic_fibrosis_transmembrane_conductance_regulator chloride channels as components of endocytic clathrin-coated vesicles .
7515047	0	chloride	31,39	cystic_fibrosis_transmembrane_conductance_regulator	55,106	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	373725(Tax:8355)	Chemical	Gene	channel|compound|START_ENTITY channel|nmod|END_ENTITY	Amino_acid residues lining the chloride channel of the cystic_fibrosis_transmembrane_conductance_regulator .
7515188	0	chloride	77,85	cystic_fibrosis_transmembrane_conductance_regulator	25,76	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Rapid endocytosis of the cystic_fibrosis_transmembrane_conductance_regulator chloride channel .
7542778	0	chloride	155,163	cystic_fibrosis_transmembrane_conductance_regulator	4,55	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	373725(Tax:8355)	Chemical	Gene	currents|compound|START_ENTITY phenotype|nmod|currents have|nmod|phenotype have|nsubj|mutations mutations|compound|END_ENTITY	Two cystic_fibrosis_transmembrane_conductance_regulator mutations have different effects on both pulmonary phenotype and regulation of outwardly rectified chloride currents .
8789091	0	chloride	100,108	cystic_fibrosis_transmembrane_conductance_regulator	48,99	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Slow conversions among subconductance states of cystic_fibrosis_transmembrane_conductance_regulator chloride channel .
8913585	0	chloride	69,77	cystic_fibrosis_transmembrane_conductance_regulator	17,68	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Rectification of cystic_fibrosis_transmembrane_conductance_regulator chloride channel mediated by extracellular divalent cations .
8968578	0	chloride	112,120	cystic_fibrosis_transmembrane_conductance_regulator	60,111	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	The tyrosine kinase p60c-src regulates the fast gate of the cystic_fibrosis_transmembrane_conductance_regulator chloride channel .
8968585	0	chloride	102,110	cystic_fibrosis_transmembrane_conductance_regulator	17,68	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	1080	Chemical	Gene	function|compound|START_ENTITY maintains|dobj|function maintains|nsubj|END_ENTITY	Human epithelial cystic_fibrosis_transmembrane_conductance_regulator without exon 5 maintains partial chloride channel function in intracellular membranes .
9089437	0	chloride	104,112	cystic_fibrosis_transmembrane_conductance_regulator	45,96	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	1080	Chemical	Gene	START_ENTITY|csubj|Locating Locating|dobj|filter filter|nmod|END_ENTITY	Locating the anion-selectivity filter of the cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- chloride channel .
9346969	0	chloride	84,92	cystic_fibrosis_transmembrane_conductance_regulator	32,83	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Function of the R domain in the cystic_fibrosis_transmembrane_conductance_regulator chloride channel .
9379167	0	chloride	94,102	cystic_fibrosis_transmembrane_conductance_regulator	42,93	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	100754506	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Halide permeation in wild-type and mutant cystic_fibrosis_transmembrane_conductance_regulator chloride channels .
9379168	0	chloride	89,97	cystic_fibrosis_transmembrane_conductance_regulator	37,88	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	100754506	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Permeability of wild-type and mutant cystic_fibrosis_transmembrane_conductance_regulator chloride channels to polyatomic anions .
9379169	0	chloride	108,116	cystic_fibrosis_transmembrane_conductance_regulator	56,107	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Multi-Ion mechanism for ion permeation and block in the cystic_fibrosis_transmembrane_conductance_regulator chloride channel .
9508802	0	chloride	140,148	cystic_fibrosis_transmembrane_conductance_regulator	88,139	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Dibasic protein kinase A sites regulate bursting rate and nucleotide sensitivity of the cystic_fibrosis_transmembrane_conductance_regulator chloride channel .
9524141	0	chloride	122,130	cystic_fibrosis_transmembrane_conductance_regulator	70,121	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	1080	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Adenosine_triphosphate-dependent asymmetry of anion permeation in the cystic_fibrosis_transmembrane_conductance_regulator chloride channel .
9792638	0	chloride	94,102	cystic_fibrosis_transmembrane_conductance_regulator	23,74	chloride	cystic fibrosis transmembrane conductance regulator	CHEBI:17996	373725(Tax:8355)	Chemical	Gene	channel|compound|START_ENTITY forms|dobj|channel forms|nsubj|half half|nmod|END_ENTITY	The second half of the cystic_fibrosis_transmembrane_conductance_regulator forms a functional chloride channel .
8900131	0	chloride	109,117	epidermal_growth_factor	64,87	chloride	epidermal growth factor	CHEBI:17996	1950	Chemical	Gene	secretion|compound|START_ENTITY END_ENTITY|nmod|secretion	Phosphatidylinositol 3-kinase mediates the inhibitory effect of epidermal_growth_factor on calcium-dependent chloride secretion .
1289180	0	chloride	57,65	erythropoietin	7,21	chloride	erythropoietin	CHEBI:17996	13856(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|secretion secretion|compound|END_ENTITY	Higher erythropoietin secretion in response to cobaltous chloride in post-hypoxic than in hypertransfused polycythemic mice .
15875066	0	chloride	46,54	hCLCA1	63,69	chloride	hCLCA1	CHEBI:17996	1179	Chemical	Gene	expression|nmod|START_ENTITY channel|nsubj|expression channel|dobj|END_ENTITY	Increased expression of the calcium-activated chloride channel hCLCA1 in airways of patients with obstructive chronic bronchitis .
23548383	0	chloride	76,84	hCLCA1	96,102	chloride	hCLCA1	CHEBI:17996	1179	Chemical	Gene	encoding|dobj|START_ENTITY vaccine|acl|encoding Safety|nmod|vaccine channel|nsubj|Safety channel|dobj|1 1|appos|END_ENTITY	Safety and immunogenicity of a DNA vaccine encoding human calcium-activated chloride channel 1 -LRB- hCLCA1 -RRB- in asthmatic mice .
8713502	0	chloride	24,32	insulin	45,52	chloride	insulin	CHEBI:17996	3630	Chemical	Gene	channels|compound|START_ENTITY channels|nmod|END_ENTITY	Regulation of mesangial chloride channels by insulin and glucose : role in diabetic_nephropathy .
1847831	0	chloride	245,253	myeloperoxidase	51,66	chloride	myeloperoxidase	CHEBI:17996	4353	Chemical	Gene	absence|dep|START_ENTITY measured|nmod|absence measured|nsubjpass|Interaction Interaction|nmod|halides halides|nmod|complex complex|nmod|END_ENTITY	Interaction of halides with the cyanide complex of myeloperoxidase : a model for substrate binding to compound I. EPR spectra of the low-spin cyanide complex of myeloperoxidase have been measured in the absence and presence of halide substrates ; chloride , bromide and iodide .
2985447	0	chloride	28,36	myeloperoxidase	65,80	chloride	myeloperoxidase	CHEBI:17996	4353	Chemical	Gene	evidence|nmod|START_ENTITY binding|nsubj|evidence binding|nmod|heme_iron heme_iron|nmod|END_ENTITY	Resonance Raman evidence of chloride binding to the heme_iron in myeloperoxidase .
2989285	0	chloride	14,22	myeloperoxidase	58,73	chloride	myeloperoxidase	CHEBI:17996	4353	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of chloride on the redox and EPR properties of myeloperoxidase .
6292181	0	chloride	87,95	myeloperoxidase	47,62	chloride	myeloperoxidase	CHEBI:17996	4353	Chemical	Gene	hydrogen_peroxide|appos|START_ENTITY END_ENTITY|nmod|hydrogen_peroxide	A kinetic analysis of the interaction of human myeloperoxidase with hydrogen_peroxide , chloride ions , and protons .
9922160	0	chloride	44,52	myeloperoxidase	12,27	chloride	myeloperoxidase	CHEBI:17996	4353	Chemical	Gene	compound|nmod|START_ENTITY compound|nsubj|Reaction Reaction|nmod|END_ENTITY	Reaction of myeloperoxidase compound I with chloride , bromide , iodide , and thiocyanate .
17353191	0	chloride	4,12	organic_anion_transporter_1	37,64	chloride	organic anion transporter 1	CHEBI:17996	9356	Chemical	Gene	dependence|compound|START_ENTITY dependence|nmod|END_ENTITY	The chloride dependence of the human organic_anion_transporter_1 -LRB- hOAT1 -RRB- is blunted by mutation of a single amino_acid .
7686908	0	chloride	49,57	p64	42,45	chloride	p64	CHEBI:17996	281862(Tax:9913)	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	Molecular cloning and characterization of p64 , a chloride channel protein from kidney microsomes .
9295337	0	chloride	55,63	p64	51,54	chloride	p64	CHEBI:17996	281862(Tax:9913)	Chemical	Gene	family|compound|START_ENTITY family|amod|END_ENTITY	Rat brain p64H1 , expression of a new member of the p64 chloride channel protein family in endoplasmic reticulum .
9592076	0	chloride	47,55	p64	25,28	chloride	p64	CHEBI:17996	3561	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	Functional expression of p64 , an intracellular chloride channel protein .
10072102	0	chloride	120,128	pituitary_adenylate_cyclase_activating_polypeptide-27	11,64	chloride	pituitary adenylate cyclase activating polypeptide-27	CHEBI:17996	116	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of pituitary_adenylate_cyclase_activating_polypeptide-27 -LRB- PACAP -RRB- and vasoactive intestinal polypeptide -LRB- VIP -RRB- on chloride in HT29 cells studied by X-ray microanalysis .
2472006	0	chloride	14,22	protein_kinase_C	35,51	chloride	protein kinase C	CHEBI:17996	112476	Chemical	Gene	channels|compound|START_ENTITY Regulation|nmod|channels Regulation|nmod|END_ENTITY	Regulation of chloride channels by protein_kinase_C in normal and cystic_fibrosis airway epithelia .
31796	0	chloride	14,22	renin	47,52	chloride	renin	CHEBI:17996	24715(Tax:10116)	Chemical	Gene	Importance|nmod|START_ENTITY Importance|nmod|inhibition inhibition|nmod|END_ENTITY	Importance of chloride for acute inhibition of renin by sodium_chloride .
3903651	0	chloride	18,26	renin	43,48	chloride	renin	CHEBI:17996	24715(Tax:10116)	Chemical	Gene	reabsorption|compound|START_ENTITY Effect|nmod|reabsorption Effect|nmod|release release|compound|END_ENTITY	Effect of reduced chloride reabsorption on renin release in the isolated rat kidney .
428074	0	chloride	40,48	renin	15,20	chloride	renin	CHEBI:17996	24715(Tax:10116)	Chemical	Gene	depletion|compound|START_ENTITY Stimulation|nmod|depletion Stimulation|nmod|END_ENTITY	Stimulation of renin by acute selective chloride depletion in the rat .
6994510	0	chloride	51,59	renin	14,19	chloride	renin	CHEBI:17996	403838(Tax:9615)	Chemical	Gene	related|nmod|START_ENTITY related|nsubjpass|Inhibition Inhibition|nmod|secretion secretion|compound|END_ENTITY	Inhibition of renin secretion by HCl is related to chloride in both dog and rat .
7032320	0	chloride	8,16	renin	26,31	chloride	renin	CHEBI:17996	5972	Chemical	Gene	modifies|nsubj|START_ENTITY modifies|dobj|release release|compound|END_ENTITY	Dietary chloride modifies renin release in normal humans .
7044145	0	chloride	59,67	renin	78,83	chloride	renin	CHEBI:17996	24715(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Effects of acute potassium infusions with salts other than chloride on plasma renin activity .
8928832	0	chloride	12,20	renin	49,54	chloride	renin	CHEBI:17996	100358545(Tax:9986)	Chemical	Gene	channels|compound|START_ENTITY Blockade|nmod|channels stimulates|nsubj|Blockade stimulates|dobj|release release|compound|END_ENTITY	Blockade of chloride channels by DIDS stimulates renin release and inhibits contraction of afferent arterioles .
8928832	6	chloride	844,852	renin	860,865	chloride	renin	CHEBI:17996	100358545(Tax:9986)	Chemical	Gene	absence|nmod|START_ENTITY suppressed|nmod|absence suppressed|nsubjpass|release release|compound|END_ENTITY	In the absence of chloride , basal renin release was suppressed and the stimulatory effect of DIDS was abolished .
19723628	0	chloride	16,24	slc26a7	37,44	chloride	slc26a7	CHEBI:17996	115111	Chemical	Gene	causes|compound|START_ENTITY causes|amod|END_ENTITY	Deletion of the chloride transporter slc26a7 causes distal_renal_tubular_acidosis and impairs gastric_acid secretion .
11292652	0	chloride	49,57	src-like_kinase	2,17	chloride	src-like kinase	CHEBI:17996	2534	Chemical	Gene	channels|compound|START_ENTITY activates|dobj|channels activates|nsubj|END_ENTITY	A src-like_kinase activates outwardly rectifying chloride channels in CFTR-defective lymphocytes .
20479003	0	chloride	33,41	tumor_necrosis_factor-alpha	53,80	chloride	tumor necrosis factor-alpha	CHEBI:17996	21926(Tax:10090)	Chemical	Gene	current|compound|START_ENTITY current|nmod|END_ENTITY	Activation of swelling-activated chloride current by tumor_necrosis_factor-alpha requires ClC-3-dependent endosomal reactive oxygen production .
6802984	0	chlorinated_bisphenols	11,33	glucose-6-phosphate_dehydrogenase	50,83	chlorinated bisphenols	glucose-6-phosphate dehydrogenase	null	855480(Tax:4932)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of chlorinated_bisphenols on torula yeast glucose-6-phosphate_dehydrogenase .
21646847	0	chlormadinone_acetate	74,95	prostate_specific_antigen	18,43	chlormadinone acetate	prostate specific antigen	MESH:D002715	354	Chemical	Gene	treatment|amod|START_ENTITY END_ENTITY|nmod|treatment	-LSB- Changes in serum prostate_specific_antigen and testosterone levels after chlormadinone_acetate treatment in patients with benign_prostatic_hyperplasia : a prospective multicenter clinical study -RSB- .
9581684	0	chlormethiazole	111,126	cytochrome_P450_2E1	80,99	chlormethiazole	cytochrome P450 2E1	MESH:D002719	25086(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Zonated expression of cytokines in rat liver : effect of chronic ethanol and the cytochrome_P450_2E1 inhibitor , chlormethiazole .
7903407	0	chloroaluminum	64,78	P-glycoprotein	30,44	chloroaluminum	P-glycoprotein	null	5243	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Effect of multidrug-resistant P-glycoprotein gene expression on chloroaluminum tetrasulfonate phthalocyanine concentration .
21062043	0	chlorobenzaldehyde_thiosemicarbazones	23,60	tyrosinase	73,83	chlorobenzaldehyde thiosemicarbazones	tyrosinase	null	7299	Chemical	Gene	kinetics|nmod|START_ENTITY END_ENTITY|nsubj|kinetics	Inhibition kinetics of chlorobenzaldehyde_thiosemicarbazones on mushroom tyrosinase .
23958639	0	chlorocinnamic_acids	23,43	tyrosinase	56,66	chlorocinnamic acids	tyrosinase	null	7299	Chemical	Gene	kinetics|nmod|START_ENTITY END_ENTITY|nsubj|kinetics	Inhibitory kinetics of chlorocinnamic_acids on mushroom tyrosinase .
6722974	0	chloroethanes	14,27	cytochrome_P-450	49,65	chloroethanes	cytochrome P-450	CHEBI:36016	25251(Tax:10116)	Chemical	Gene	Metabolism|nmod|START_ENTITY Metabolism|nmod|END_ENTITY	Metabolism of chloroethanes by rat liver nuclear cytochrome_P-450 .
8102648	0	chloroethylclonidine	26,46	alpha_1B-adrenoceptor	64,85	chloroethylclonidine	alpha 1B-adrenoceptor	MESH:C051731	24173(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Cardiovascular effects of chloroethylclonidine , an irreversible alpha_1B-adrenoceptor antagonist , in the unanesthetized rat : a pharmacological analysis in vivo and in vitro .
1971568	0	chlorofluoroacetamides	26,48	cytochrome_P-450	107,123	chlorofluoroacetamides	cytochrome P-450	null	25251(Tax:10116)	Chemical	Gene	inactivation|nmod|START_ENTITY inactivation|nmod|END_ENTITY	Selective inactivation by chlorofluoroacetamides of the major phenobarbital-inducible form -LRB- s -RRB- of rat liver cytochrome_P-450 .
25172696	0	chlorogenic_acid	28,44	IL-8	52,56	chlorogenic acid	IL-8	MESH:D002726	3576	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Anti-inflammatory effect of chlorogenic_acid on the IL-8 production in Caco-2 cells and the dextran sulphate_sodium-induced colitis symptoms in C57BL/6 mice .
22353630	0	chlorogenic_acid	73,89	NQO1	102,106	chlorogenic acid	NQO1	MESH:D002726	1728	Chemical	Gene	START_ENTITY|dobj|expression expression|compound|END_ENTITY	Caffeinated coffee , decaffeinated coffee , and the phenolic phytochemical chlorogenic_acid up-regulate NQO1 expression and prevent H ___ O - induced apoptosis in primary cortical neurons .
25744394	0	chlorogenic_acid	65,81	TLR2	15,19	chlorogenic acid	TLR2	MESH:D002726	7097	Chemical	Gene	effects|nmod|START_ENTITY Involvement|nmod|effects Involvement|nmod|END_ENTITY	Involvement of TLR2 and TLR9 in the anti-inflammatory effects of chlorogenic_acid in HSV-1-infected microglia .
19618689	0	chlorogenic_acid	22,38	peroxisome_proliferator-activated_receptor-alpha	98,146	chlorogenic acid	peroxisome proliferator-activated receptor-alpha	MESH:D002726	101827388	Chemical	Gene	metabolism|amod|START_ENTITY effects|nmod|metabolism effects|nmod|END_ENTITY	Modulating effects of chlorogenic_acid on lipids and glucose metabolism and expression of hepatic peroxisome_proliferator-activated_receptor-alpha in golden_hamsters fed on high fat diet .
10698435	0	chloromethyl_ketone	43,62	chymase	95,102	chloromethyl ketone	chymase	null	1215	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Structure-activity relationship studies of chloromethyl_ketone derivatives for selective human chymase inhibitors .
447643	0	chloromethyl_ketones	82,102	leukocyte_elastase	20,38	chloromethyl ketones	leukocyte elastase	null	1991	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of human leukocyte_elastase by acetyl and trifluoroacetyl oligopeptide chloromethyl_ketones .
6901613	0	chloromethyl_ketones	53,73	pancreatic_elastase_2	20,41	chloromethyl ketones	pancreatic elastase 2	null	63036	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of human pancreatic_elastase_2 by peptide chloromethyl_ketones .
8568563	0	chloromethyl_ketones	54,74	thrombin	14,22	chloromethyl ketones	thrombin	null	2147	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of thrombin by arginine-containing peptide chloromethyl_ketones and bis chloromethyl_ketone-albumin conjugates .
17553115	0	chlorophyll	57,68	ELIP2	33,38	chlorophyll	ELIP2	MESH:D002734	827119(Tax:3702)	Chemical	Gene	synthesis|amod|START_ENTITY regulator|nmod|synthesis regulator|nsubj|END_ENTITY	The light stress-induced protein ELIP2 is a regulator of chlorophyll synthesis in Arabidopsis_thaliana .
15570051	0	chlorophyllin	26,39	E-cadherin	47,57	chlorophyllin	E-cadherin	MESH:C007020	999	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|expression expression|amod|END_ENTITY	The dietary phytochemical chlorophyllin alters E-cadherin and beta-catenin expression in human colon_cancer cells .
1446675	0	chloroplast	14,25	ATPase	26,32	chloroplast	ATPase	null	36731(Tax:7227)	Chemical	Gene	Inhibition|nmod|START_ENTITY END_ENTITY|nsubj|Inhibition	Inhibition of chloroplast ATPase by the K + channel blocker alpha-dendrotoxin .
11469595	0	chloroplast	6,17	carbonic_anhydrase	27,45	chloroplast	carbonic anhydrase	null	5717875(Tax:3055)	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	A new chloroplast envelope carbonic_anhydrase activity is induced during acclimation to low inorganic carbon concentrations in Chlamydomonas_reinhardtii .
24946858	0	chloroquine	30,41	AKT	10,13	chloroquine	AKT	MESH:D002738	207	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Combining AKT inhibition with chloroquine and gefitinib prevents compensatory autophagy and induces cell death in EGFR mutated NSCLC cells .
18691894	0	chloroquine	100,111	Akt	54,57	chloroquine	Akt	MESH:D002738	207	Chemical	Gene	increased|nmod|START_ENTITY increased|nsubjpass|efficacy efficacy|nmod|cell cell|acl|killing killing|nmod|inhibitors inhibitors|compound|END_ENTITY	The efficacy and selectivity of tumor cell killing by Akt inhibitors are substantially increased by chloroquine .
16696308	0	chloroquine	11,22	GFAP	26,30	chloroquine	GFAP	MESH:D002738	24387(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of chloroquine on GFAP , PCNA and cyclin_D1 in hippocampus and cerebral cortex of rats with seizures induced by pentylenetetrazole .
22615284	0	chloroquine	69,80	Hsp90	43,48	chloroquine	Hsp90	MESH:D002738	3320	Chemical	Gene	targeting|nmod|START_ENTITY targeting|dobj|END_ENTITY	Harmine is a potent antimalarial targeting Hsp90 and synergizes with chloroquine and artemisinin .
1425913	0	chloroquine	123,134	Interferon-gamma	0,16	chloroquine	Interferon-gamma	MESH:D002738	15978(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|END_ENTITY	Interferon-gamma induced lethality in the late phase of Plasmodium vinckei malaria despite effective parasite clearance by chloroquine .
9751078	0	chloroquine	18,29	MRP	67,70	chloroquine	MRP	MESH:D002738	4363	Chemical	Gene	Direct|nmod|START_ENTITY Direct|nmod|multidrug_resistance_protein multidrug_resistance_protein|appos|END_ENTITY	Direct binding of chloroquine to the multidrug_resistance_protein -LRB- MRP -RRB- : possible role for MRP in chloroquine drug transport and resistance in tumor cells .
9751078	0	chloroquine	18,29	MRP	91,94	chloroquine	MRP	MESH:D002738	4363	Chemical	Gene	Direct|nmod|START_ENTITY Direct|dep|role role|nmod|END_ENTITY	Direct binding of chloroquine to the multidrug_resistance_protein -LRB- MRP -RRB- : possible role for MRP in chloroquine drug transport and resistance in tumor cells .
9751078	0	chloroquine	98,109	MRP	67,70	chloroquine	MRP	MESH:D002738	4363	Chemical	Gene	transport|amod|START_ENTITY MRP|nmod|transport role|nmod|MRP Direct|dep|role Direct|nmod|multidrug_resistance_protein multidrug_resistance_protein|appos|END_ENTITY	Direct binding of chloroquine to the multidrug_resistance_protein -LRB- MRP -RRB- : possible role for MRP in chloroquine drug transport and resistance in tumor cells .
9751078	0	chloroquine	98,109	MRP	91,94	chloroquine	MRP	MESH:D002738	4363	Chemical	Gene	transport|amod|START_ENTITY END_ENTITY|nmod|transport	Direct binding of chloroquine to the multidrug_resistance_protein -LRB- MRP -RRB- : possible role for MRP in chloroquine drug transport and resistance in tumor cells .
7165718	0	chloroquine	14,25	beta-hexosaminidase	75,94	chloroquine	beta-hexosaminidase	MESH:D002738	10724	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nsubj|effect	The effect of chloroquine on the distribution of newly synthesized and old beta-hexosaminidase in fibroblasts .
3539675	0	chloroquine	57,68	insulin	14,21	chloroquine	insulin	MESH:D002738	396145(Tax:9031)	Chemical	Gene	uptake|nmod|START_ENTITY action|nmod|uptake action|compound|END_ENTITY	Modulation of insulin action on 2-deoxyglucose uptake by chloroquine in chick embryo fibroblasts .
7041240	0	chloroquine	55,66	insulin	26,33	chloroquine	insulin	MESH:D002738	3630	Chemical	Gene	treatment|amod|START_ENTITY END_ENTITY|nmod|treatment	Glucose tolerance , plasma insulin and C-peptide during chloroquine treatment of rheumatoid_arthritis .
6462370	0	chloroquine	57,68	prolactin	15,24	chloroquine	prolactin	MESH:D002738	24683(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY release|dep|effect release|nmod|END_ENTITY	The release of prolactin in the lactating rat : effect of chloroquine .
11922021	0	chloroquine	42,53	transferrin	57,68	chloroquine	transferrin	MESH:D002738	24825(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Direct toxic effects of clinical doses of chloroquine on transferrin secretion in immature rat sertoli cells in vitro .
20064914	0	chloroquine_phosphate	10,31	MMP-9	51,56	chloroquine phosphate	MMP-9	MESH:C023676	4318	Chemical	Gene	treatment|amod|START_ENTITY Effect|nmod|treatment Effect|nmod|END_ENTITY	Effect of chloroquine_phosphate treatment on serum MMP-9 and TIMP-1 levels in patients with systemic_lupus_erythematosus .
18847257	0	chlorosilanes_Cl3-nHnSiOCH2CH2NMe2	47,81	Si-N	22,26	chlorosilanes Cl3-nHnSiOCH2CH2NMe2	Si-N	null	10278	Chemical	Gene	interactions|nmod|START_ENTITY interactions|amod|END_ENTITY	Strong intramolecular Si-N interactions in the chlorosilanes_Cl3-nHnSiOCH2CH2NMe2 -LRB- n = 1-3 -RRB- .
22123130	0	chlorothiazide	16,30	ABCG2	0,5	chlorothiazide	ABCG2	MESH:D002740	9429	Chemical	Gene	START_ENTITY|nsubj|modulates modulates|compound|END_ENTITY	ABCG2 modulates chlorothiazide permeability in vitro - characterization of the interaction .
22790065	0	chlorothiazide	16,30	ABCG2	0,5	chlorothiazide	ABCG2	MESH:D002740	9429	Chemical	Gene	START_ENTITY|nsubj|modulates modulates|compound|END_ENTITY	ABCG2 modulates chlorothiazide permeability -- in vitro-characterization of its interactions .
6758648	0	chlorothiazide	61,75	renin	12,17	chlorothiazide	renin	MESH:D002740	24715(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of renin in the paradoxical antipolyuric effects of chlorothiazide in the homozygous Brattleboro rat .
6810984	0	chlorotrianisene	15,31	Tace	33,37	chlorotrianisene	Tace	MESH:D002741	6868	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	The effects of chlorotrianisene -LRB- Tace -RRB- of kinetics of 3H-testosterone metabolism in patients with carcinoma_of_the_prostate .
739556	0	chlorpromazine	82,96	Acetylcholinesterase	0,20	chlorpromazine	Acetylcholinesterase	MESH:D002746	489828(Tax:9615)	Chemical	Gene	effect|nmod|START_ENTITY activity|dep|effect activity|amod|END_ENTITY	Acetylcholinesterase activity in ventricular and cisternal CSF of dogs : effect of chlorpromazine .
21683644	0	chlorpromazine	110,124	Bcl2l1	14,20	chlorpromazine	Bcl2l1	MESH:D002746	12048(Tax:10090)	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of Bcl2l1 , Clcf1 , IL-28ra and Pias1 in the mouse heart after single and repeated administration of chlorpromazine .
12788816	0	chlorpromazine	23,37	HERG	47,51	chlorpromazine	HERG	MESH:D002746	3757	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	The antipsychotic drug chlorpromazine inhibits HERG potassium channels .
15071359	0	chlorpromazine	73,87	HERG	9,13	chlorpromazine	HERG	MESH:D002746	3757	Chemical	Gene	guinea_pig|nmod|START_ENTITY channel|acl|guinea_pig Block|dep|channel Block|acl|END_ENTITY	Block of HERG human K -LRB- + -RRB- channel and IKr of guinea_pig cardiomyocytes by chlorpromazine .
15462192	0	chlorpromazine	10,24	MAO-A	52,57	chlorpromazine	MAO-A	MESH:D002746	29253(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	Effect of chlorpromazine , imipramine and lithium on MAO-A and MAO-B activity in rat brain mitochondria .
12860438	0	chlorpromazine	25,39	TNF-alpha	136,145	chlorpromazine	TNF-alpha	MESH:D002746	24835(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|levels levels|amod|END_ENTITY	Contradictory effects of chlorpromazine on endothelial cells in a rat model of endotoxic_shock in association with its actions on serum TNF-alpha levels and antioxidant enzyme activities .
1159049	0	chlorpromazine	14,28	beta-MSH	64,72	chlorpromazine	beta-MSH	MESH:D002746	5443	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|nmod|END_ENTITY	The effect of chlorpromazine on the secretion of immunoreactive beta-MSH and prolactin in man .
1097237	0	chlorpromazine	71,85	growth_hormone	37,51	chlorpromazine	growth hormone	MESH:D002746	81668(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Studies Studies|nmod|release release|compound|END_ENTITY	Studies on the mechanism controlling growth_hormone release induced by chlorpromazine in the anesthetized rat .
2864652	0	chlorpromazine	98,112	growth_hormone	7,21	chlorpromazine	growth hormone	MESH:D002746	2688	Chemical	Gene	administered|nmod|START_ENTITY rats|acl|administered growth_hormone_releasing_factor|nmod|rats END_ENTITY|nmod|growth_hormone_releasing_factor	Plasma growth_hormone response to human growth_hormone_releasing_factor in rats administered with chlorpromazine and antiserum against somatostatin .
453353	0	chlorpromazine	10,24	growth_hormone	34,48	chlorpromazine	growth hormone	MESH:D002746	2688	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of chlorpromazine on human growth_hormone .
6104306	0	chlorpromazine	11,25	growth_hormone	42,56	chlorpromazine	growth hormone	MESH:D002746	81668(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|amod|END_ENTITY	Effects of chlorpromazine and naloxone on growth_hormone secretion in rats .
635430	0	chlorpromazine	14,28	growth_hormone	74,88	chlorpromazine	growth hormone	MESH:D002746	81668(Tax:10116)	Chemical	Gene	action|nmod|START_ENTITY action|nmod|END_ENTITY	The action of chlorpromazine upon the serum and hypophyseal variations of growth_hormone , prolactin and TSH in the male adult rat under continuous-lighting stress .
7418239	0	chlorpromazine	12,26	growth_hormone	91,105	chlorpromazine	growth hormone	MESH:D002746	81668(Tax:10116)	Chemical	Gene	polypeptide|amod|START_ENTITY polypeptide|nmod|levels levels|compound|END_ENTITY	-LSB- Effects of chlorpromazine , beta-endorphin and vasoactive intestinal polypeptide on plasma growth_hormone levels in unanesthetized rats -LRB- author 's transl -RRB- -RSB- .
1989514	0	chlorpromazine	13,27	methemoglobin	31,44	chlorpromazine	methemoglobin	MESH:D002746	3048	Chemical	Gene	Oxidation|nmod|START_ENTITY Oxidation|nmod|END_ENTITY	Oxidation of chlorpromazine by methemoglobin in the presence of hydrogen_peroxide .
1989514	1	chlorpromazine	96,110	methemoglobin	154,167	chlorpromazine	methemoglobin	MESH:D002746	3048	Chemical	Gene	cation|amod|START_ENTITY Formation|nmod|cation binding|nsubj|Formation binding|xcomp|END_ENTITY	Formation of chlorpromazine radical cation and its covalent binding to methemoglobin .
8010989	0	chlorpromazine	15,29	myoglobin	35,44	chlorpromazine	myoglobin	MESH:D002746	4151	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of chlorpromazine with myoglobin and hemoglobin .
335789	0	chlorpromazine	10,24	prolactin	38,47	chlorpromazine	prolactin	MESH:D002746	5617	Chemical	Gene	treatment|amod|START_ENTITY Effect|nmod|treatment Effect|nmod|levels levels|compound|END_ENTITY	Effect of chlorpromazine treatment on prolactin levels in cerebrospinal fluid and plasma of psychotic patients .
45130	0	chlorpromazine	47,61	prolactin	6,15	chlorpromazine	prolactin	MESH:D002746	5617	Chemical	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	Serum prolactin levels following intramuscular chlorpromazine : two - and three-hour response as predictors of six-hour response .
477628	0	chlorpromazine	11,25	prolactin	52,61	chlorpromazine	prolactin	MESH:D002746	24683(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of chlorpromazine and estradiol_benzoate on prolactin secretion in gonadectomized male and female rats .
580204	0	chlorpromazine	76,90	prolactin	6,15	chlorpromazine	prolactin	MESH:D002746	5617	Chemical	Gene	administration|nmod|START_ENTITY Serum|nmod|administration Serum|dobj|levels levels|compound|END_ENTITY	Serum prolactin levels after a single and subchronic oral administration of chlorpromazine and sulpiride .
6109449	0	chlorpromazine	28,42	prolactin	58,67	chlorpromazine	prolactin	MESH:D002746	5617	Chemical	Gene	stimulation|amod|START_ENTITY stimulation|nmod|END_ENTITY	Effect of cyproheptadine on chlorpromazine stimulation of prolactin in women .
6111824	0	chlorpromazine	94,108	prolactin	72,81	chlorpromazine	prolactin	MESH:D002746	5617	Chemical	Gene	challenge|amod|START_ENTITY response|nmod|challenge response|compound|END_ENTITY	Neuroendocrine tests during treatment with neuroleptic drugs : I. Plasma prolactin response to chlorpromazine challenge .
6133307	0	chlorpromazine	168,182	prolactin	106,115	chlorpromazine	prolactin	MESH:D002746	5617	Chemical	Gene	treatment|compound|START_ENTITY receiving|dobj|treatment blocking|advcl|receiving blocking|nmod|level level|compound|END_ENTITY	Dopamine , serotonin and alpha-adrenergic receptor blocking activities in serum and their relationships to prolactin level in schizophrenic patients receiving long-term chlorpromazine treatment .
6308934	0	chlorpromazine	71,85	prolactin	49,58	chlorpromazine	prolactin	MESH:D002746	5617	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Lack of effect of chronic hypocalcaemia on serum prolactin response to chlorpromazine .
6580661	0	chlorpromazine	28,42	prolactin	6,15	chlorpromazine	prolactin	MESH:D002746	5617	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Serum prolactin response to chlorpromazine and psychopathology in schizophrenics : implications for the dopamine hypothesis .
6807580	0	chlorpromazine	29,43	prolactin	16,25	chlorpromazine	prolactin	MESH:D002746	5617	Chemical	Gene	response|acl|START_ENTITY response|nmod|END_ENTITY	The response of prolactin to chlorpromazine stimulation in men with hypogonadotrophic_hypogonadism and early pubertal boys : relationship to sex steroid exposure .
6944710	0	chlorpromazine	24,38	prolactin	48,57	chlorpromazine	prolactin	MESH:D002746	5617	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Effect of intramuscular chlorpromazine on serum prolactin levels in schizophrenic patients and normal controls .
7287876	0	chlorpromazine	22,36	prolactin	40,49	chlorpromazine	prolactin	MESH:D002746	5617	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|compound|END_ENTITY	Stimulatory effect of chlorpromazine on prolactin secretion in anencephalic infants .
844484	0	chlorpromazine	25,39	prolactin	50,59	chlorpromazine	prolactin	MESH:D002746	24683(Tax:10116)	Chemical	Gene	metabolites|nmod|START_ENTITY Effect|nmod|metabolites Effect|nmod|levels levels|compound|END_ENTITY	Effect of metabolites of chlorpromazine on plasma prolactin levels in male rats .
8997623	0	chlorpromazine	63,77	tumor_necrosis_factor	27,48	chlorpromazine	tumor necrosis factor	MESH:D002746	21926(Tax:10090)	Chemical	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	Mechanism of inhibition of tumor_necrosis_factor production by chlorpromazine and its derivatives in mice .
9409530	0	chlorpromazine	78,92	tumor_necrosis_factor	33,54	chlorpromazine	tumor necrosis factor	MESH:D002746	280943(Tax:9913)	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|effect effect|nmod|END_ENTITY	Inhibitory effect on LPS-induced tumor_necrosis_factor in calves treated with chlorpromazine or pentoxifylline .
12512871	0	chlorpromazine_hydrochloride	40,68	p53	92,95	chlorpromazine hydrochloride	p53	MESH:D002746	22060(Tax:10090)	Chemical	Gene	studies|nmod|START_ENTITY studies|nmod|END_ENTITY	Toxicity and carcinogenicity studies of chlorpromazine_hydrochloride and p-cresidine in the p53 heterozygous mouse model .
6759080	0	chlorpropamide	25,39	C-peptide	52,61	chlorpropamide	C-peptide	MESH:D002747	3630	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The long-term effects of chlorpropamide on insulin , C-peptide , and proinsulin secretion .
6759080	0	chlorpropamide	25,39	insulin	43,50	chlorpropamide	insulin	MESH:D002747	3630	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|C-peptide C-peptide|compound|END_ENTITY	The long-term effects of chlorpropamide on insulin , C-peptide , and proinsulin secretion .
7045153	0	chlorpropamide	8,22	insulin	94,101	chlorpropamide	insulin	MESH:D002747	3630	Chemical	Gene	therapy|compound|START_ENTITY augments|nsubj|therapy augments|dobj|secretion secretion|compound|END_ENTITY	Chronic chlorpropamide therapy of noninsulin-dependent diabetes augments basal and stimulated insulin secretion by increasing islet sensitivity to glucose .
913926	0	chlorpropamide	75,89	insulin	7,14	chlorpropamide	insulin	MESH:D002747	3630	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|END_ENTITY	Plasma insulin and glucose levels in maturity onset diabetics treated with chlorpropamide .
169346	0	chlorpropamide	10,24	parathyroid_hormone	46,65	chlorpropamide	parathyroid hormone	MESH:D002747	5741	Chemical	Gene	Effect|nmod|START_ENTITY Effect|acl|END_ENTITY	Effect of chlorpropamide on renal response to parathyroid_hormone in normal subjects and in patients with hypoparathyroidism and pseudohypoparathyroidism .
4303530	0	chlorpropamide	10,24	vasopressin	100,111	chlorpropamide	vasopressin	MESH:D002747	551	Chemical	Gene	Effect|nmod|START_ENTITY Effect|acl|END_ENTITY	Effect of chlorpropamide on the permeability of the urinary bladder of the toad and the response to vasopressin , adenosine-3 ' ,5 ' - monophosphate and theophylline .
11278057	0	chlorpropham	11,23	CIPC	25,29	chlorpropham	CIPC	MESH:D002748	314330(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of chlorpropham -LRB- CIPC -RRB- on the hemopoietic system of rats .
11386720	0	chlorpyrifos	78,90	Acetylcholinesterase	0,20	chlorpyrifos	Acetylcholinesterase	MESH:D004390	43	Chemical	Gene	mussel|nmod|START_ENTITY inhibition|nmod|mussel inhibition|amod|END_ENTITY	Acetylcholinesterase inhibition in the threeridge mussel -LRB- Amblema plicata -RRB- by chlorpyrifos : implications for biomonitoring .
10514030	0	chlorpyrifos	37,49	Tumor_necrosis_factor	0,21	chlorpyrifos	Tumor necrosis factor	MESH:D004390	103694380	Chemical	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	Tumor_necrosis_factor is involved in chlorpyrifos -- induced changes in core temperature in the female rat .
10051415	0	chlorpyrifos	125,137	acetylcholinesterase	21,41	chlorpyrifos	acetylcholinesterase	MESH:D004390	43	Chemical	Gene	dose|amod|START_ENTITY establishing|dobj|dose endpoint|acl|establishing END_ENTITY|nmod|endpoint	Human red blood cell acetylcholinesterase inhibition as the appropriate and conservative surrogate endpoint for establishing chlorpyrifos reference dose .
10544056	0	chlorpyrifos	55,67	acetylcholinesterase	92,112	chlorpyrifos	acetylcholinesterase	MESH:D004390	83817(Tax:10116)	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|dep|is is|nsubj|END_ENTITY	Neuronal differentiation in PC12 cells is inhibited by chlorpyrifos and its metabolites : is acetylcholinesterase inhibition the site of action ?
10873710	0	chlorpyrifos	32,44	acetylcholinesterase	87,107	chlorpyrifos	acetylcholinesterase	MESH:D004390	83817(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY analogs|nsubj|effects analogs|nmod|markers markers|amod|neuronal neuronal|dep|END_ENTITY	Maturation-dependent effects of chlorpyrifos and parathion and their oxygen analogs on acetylcholinesterase and neuronal and glial markers in aggregating brain cell cultures .
11332845	0	chlorpyrifos	51,63	acetylcholinesterase	67,87	chlorpyrifos	acetylcholinesterase	MESH:D004390	43	Chemical	Gene	applied|dobj|START_ENTITY applied|nmod|esterases esterases|amod|END_ENTITY	Decapitation impacting effect of topically applied chlorpyrifos on acetylcholinesterase and general esterases in susceptible and resistant German cockroaches -LRB- Dictyoptera : Blattellidae -RRB- .
15893801	0	chlorpyrifos	43,55	acetylcholinesterase	65,85	chlorpyrifos	acetylcholinesterase	MESH:D004390	100158421(Tax:8355)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Exposure to the organophosphorus pesticide chlorpyrifos inhibits acetylcholinesterase activity and affects muscular integrity in Xenopus_laevis larvae .
16753212	0	chlorpyrifos	139,151	acetylcholinesterase	57,77	chlorpyrifos	acetylcholinesterase	MESH:D004390	100697913	Chemical	Gene	size-related|nmod|START_ENTITY size-related|nmod|inhibition inhibition|nmod|activity activity|compound|END_ENTITY	Body size-related differences in the inhibition of brain acetylcholinesterase activity in juvenile Nile_tilapia -LRB- Oreochromis_niloticus -RRB- by chlorpyrifos and carbosulfan .
16838488	0	chlorpyrifos	201,213	acetylcholinesterase	45,65	chlorpyrifos	acetylcholinesterase	MESH:D004390	43	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubj|Synthesis Synthesis|nmod|reactivators reactivators|nmod|END_ENTITY	-LSB- Synthesis of reactivators of phosphorylated acetylcholinesterase of bis-pyridiniumdialdoxime type with a 3-oxapentane connecting chain and their testing in vitro on a model of the enzyme inhibited by chlorpyrifos and methylchlorpyrifos -RSB- .
17265677	0	chlorpyrifos	69,81	acetylcholinesterase	93,113	chlorpyrifos	acetylcholinesterase	MESH:D004390	83817(Tax:10116)	Chemical	Gene	reactivators|dep|START_ENTITY oximes|nmod|reactivators inhibited|nsubj|oximes inhibited|xcomp|END_ENTITY	Substituted monoquaternary oximes as reactivators of cyclosarin -- and chlorpyrifos -- inhibited acetylcholinesterase .
17366821	0	chlorpyrifos	119,131	acetylcholinesterase	26,46	chlorpyrifos	acetylcholinesterase	MESH:D004390	83817(Tax:10116)	Chemical	Gene	functions|dep|START_ENTITY functions|nmod|variants variants|amod|END_ENTITY	Nonenzymatic functions of acetylcholinesterase splice variants in the developmental neurotoxicity of organophosphates : chlorpyrifos , chlorpyrifos oxon , and diazinon .
18254274	0	chlorpyrifos	162,174	acetylcholinesterase	116,136	chlorpyrifos	acetylcholinesterase	MESH:D004390	43	Chemical	Gene	pesticides|dep|START_ENTITY inhibited|nmod|pesticides inhibited|nsubj|Evaluation Evaluation|nmod|potency potency|nmod|oximes oximes|nmod|END_ENTITY	Evaluation of potency of known oximes -LRB- pralidoxime , trimedoxime , HI-6 , methoxime , obidoxime -RRB- to in vitro reactivate acetylcholinesterase inhibited by pesticides -LRB- chlorpyrifos and methylchlorpyrifos -RRB- and nerve agent -LRB- Russian VX -RRB- .
18371683	0	chlorpyrifos	31,43	acetylcholinesterase	83,103	chlorpyrifos	acetylcholinesterase	MESH:D004390	43	Chemical	Gene	biosensor|nmod|START_ENTITY biosensor|acl|using using|dobj|film film|acl|containing containing|xcomp|END_ENTITY	An optical fiber biosensor for chlorpyrifos using a single sol-gel film containing acetylcholinesterase and bromothymol_blue .
20112867	0	chlorpyrifos	114,126	acetylcholinesterase	19,39	chlorpyrifos	acetylcholinesterase	MESH:D004390	43	Chemical	Gene	exposed|nmod|START_ENTITY exposed|nsubj|expression expression|nmod|END_ENTITY	Gene expression of acetylcholinesterase in hybrid catfish -LRB- Clarias gariepinus X Clarias macrocephalus -RRB- exposed to chlorpyrifos and carbaryl .
21377346	0	chlorpyrifos	82,94	acetylcholinesterase	47,67	chlorpyrifos	acetylcholinesterase	MESH:D004390	43	Chemical	Gene	biosensor|nmod|START_ENTITY biosensor|compound|END_ENTITY	A novel , sensitive , reusable and low potential acetylcholinesterase biosensor for chlorpyrifos based on 1-butyl-3-methylimidazolium_tetrafluoroborate / multiwalled carbon nanotubes gel .
22036888	0	chlorpyrifos	48,60	acetylcholinesterase	13,33	chlorpyrifos	acetylcholinesterase	MESH:D004390	114549(Tax:7955)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Differential acetylcholinesterase inhibition of chlorpyrifos , diazinon and parathion in larval zebrafish .
23535398	0	chlorpyrifos	113,125	acetylcholinesterase	30,50	chlorpyrifos	acetylcholinesterase	MESH:D004390	43	Chemical	Gene	administration|amod|START_ENTITY END_ENTITY|nmod|administration	Dose-dependent regional brain acetylcholinesterase and acylpeptide_hydrolase inhibition without cell death after chlorpyrifos administration .
23622518	0	chlorpyrifos	10,22	acetylcholinesterase	55,75	chlorpyrifos	acetylcholinesterase	MESH:D004390	540446(Tax:9913)	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of chlorpyrifos on the inhibition of the enzyme acetylcholinesterase by cross-linking in water-supply samples and milk from dairy cattle .
7537966	0	chlorpyrifos	104,116	acetylcholinesterase	21,41	chlorpyrifos	acetylcholinesterase	MESH:D004390	83817(Tax:10116)	Chemical	Gene	dosing|nmod|START_ENTITY inhibition|nmod|dosing inhibition|nsubj|accumulation accumulation|nmod|END_ENTITY	Slow accumulation of acetylcholinesterase in rat brain during enzyme inhibition by repeated dosing with chlorpyrifos .
11502728	0	chlorpyrifos	14,26	cytochrome_P450	36,51	chlorpyrifos	cytochrome P450	MESH:D004390	4051	Chemical	Gene	START_ENTITY|nmod|isoforms isoforms|amod|END_ENTITY	Metabolism of chlorpyrifos by human cytochrome_P450 isoforms and human , mouse , and rat liver microsomes .
14555401	0	chlorpyrifos	196,208	glial_fibrillary_acidic_protein	24,55	chlorpyrifos	glial fibrillary acidic protein	MESH:D004390	24387(Tax:10116)	Chemical	Gene	exposure|nmod|START_ENTITY acetylcholinesterase|nmod|exposure expression|dep|acetylcholinesterase expression|nmod|END_ENTITY	Increased expression of glial_fibrillary_acidic_protein in cerebellum and hippocampus : differential effects on neonatal brain regional acetylcholinesterase following maternal exposure to combined chlorpyrifos and nicotine .
21385392	0	chlorpyrifos	83,95	glial_fibrillary_acidic_protein	117,148	chlorpyrifos	glial fibrillary acidic protein	MESH:D004390	14580(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of consequent exposure of stress and dermal application of low doses of chlorpyrifos on the expression of glial_fibrillary_acidic_protein in the hippocampus of adult mice .
9744565	0	chlorpyrifos-oxon	64,81	acetylcholinesterase	14,34	chlorpyrifos-oxon	acetylcholinesterase	MESH:C009618	43	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of acetylcholinesterase and butyrylcholinesterase by chlorpyrifos-oxon .
22100607	0	chlorpyrifos_oxon	88,105	carboxylesterase_1_and_2	32,56	chlorpyrifos oxon	carboxylesterase 1 and 2	MESH:C009618	1066;8824	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of recombinant human carboxylesterase_1_and_2 and monoacylglycerol_lipase by chlorpyrifos_oxon , paraoxon and methyl_paraoxon .
3595865	0	chlortetracycline	35,52	seminalplasmin	15,29	chlortetracycline	seminalplasmin	MESH:D002751	280905(Tax:9913)	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of seminalplasmin with chlortetracycline , a fluorescent chelate probe of Ca2 + .
23301016	0	chlorzoxazone	102,115	CYP2E1	119,125	chlorzoxazone	CYP2E1	MESH:D002753	25086(Tax:10116)	Chemical	Gene	START_ENTITY|appos|substrate substrate|compound|END_ENTITY	Concentration-dependent inhibitory effect of Baicalin on the plasma protein binding and metabolism of chlorzoxazone , a CYP2E1 probe substrate , in rats in vitro and in vivo .
9212147	0	chlorzoxazone	48,61	CYP2E1	79,85	chlorzoxazone	CYP2E1	MESH:D002753	100342572(Tax:9986)	Chemical	Gene	START_ENTITY|appos|substrate substrate|nmod|END_ENTITY	Halothane inhalation inhibits the metabolism of chlorzoxazone , a substrate for CYP2E1 , in rabbits .
9597564	0	chlorzoxazone	7,20	cytochrome_P450_2E1	44,63	chlorzoxazone	cytochrome P450 2E1	MESH:D002753	1571	Chemical	Gene	START_ENTITY|nmod|probe probe|nmod|END_ENTITY	Use of chlorzoxazone as an in vivo probe of cytochrome_P450_2E1 : choice of dose and phenotypic trait measure .
12757833	0	chlorzoxazone	83,96	growth_hormone	29,43	chlorzoxazone	growth hormone	MESH:D002753	2688	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of recombinant human growth_hormone on the pharmacokinetics of intravenous chlorzoxazone in rats with acute_renal_failure induced by uranyl_nitrate .
19183878	0	cholalic_acid	26,39	TNFalpha	87,95	cholalic acid	TNFalpha	null	24835(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	The inhibitory effects of cholalic_acid and hyodeoxycholalic_acid on the expression of TNFalpha and IL-1beta after cerebral_ischemia in rats .
26607331	1	cholanoic_acid	61,75	G-protein_coupled_bile_acid_receptor_1	98,136	cholanoic acid	G-protein coupled bile acid receptor 1	MESH:C007036	151306	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Discovery of cholanoic_acid derivatives with dual G-protein_coupled_bile_acid_receptor_1 -LRB- GPBAR1 -RRB- antagonistic and farnesoid_X_receptor -LRB- FXR -RRB- modulatory activity .
21832985	0	cholecalciferol	5,20	TGF-b1	55,61	cholecalciferol	TGF-b1	MESH:D002762	7040	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|END_ENTITY	Oral cholecalciferol decreases albuminuria and urinary TGF-b1 in patients with type 2 diabetic_nephropathy on established renin-angiotensin-aldosterone system inhibition .
180950	0	cholecalciferol	66,81	calcium_binding_protein	12,35	cholecalciferol	calcium binding protein	MESH:D002762	1068	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of calcium_binding_protein in the mechanism of action of cholecalciferol -LRB- vitamin_D3 -RRB- .
10702588	0	cholecalciferol	9,24	parathyroid_hormone	70,89	cholecalciferol	parathyroid hormone	MESH:D002762	24694(Tax:10116)	Chemical	Gene	nutrition|amod|START_ENTITY END_ENTITY|nsubj|nutrition	Improved cholecalciferol nutrition in rats is noncalcemic , suppresses parathyroid_hormone and increases responsiveness to 1 , _ 25-dihydroxycholecalciferol .
21996984	0	cholecalciferol	10,25	parathyroid_hormone	29,48	cholecalciferol	parathyroid hormone	MESH:D002762	5741	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|amod|END_ENTITY	Effect of cholecalciferol on parathyroid_hormone and vitamin_D levels in chronic_kidney_disease .
22854402	0	cholecalciferol	10,25	parathyroid_hormone	34,53	cholecalciferol	parathyroid hormone	MESH:D002762	5741	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	High-dose cholecalciferol reduces parathyroid_hormone in patients with early chronic_kidney_disease : a pilot , randomized , double-blind , placebo-controlled trial .
8172088	0	cholecalciferol	12,27	parathyroid_hormone	62,81	cholecalciferol	parathyroid hormone	MESH:D002762	5741	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|concentrations concentrations|amod|END_ENTITY	Single-dose cholecalciferol suppresses the winter increase in parathyroid_hormone concentrations in healthy older men and women : a randomized trial .
23954476	0	cholecystokinin	23,38	Apelin	0,6	cholecystokinin	Apelin	MESH:D002766	58812(Tax:10116)	Chemical	Gene	stimulates|dobj|START_ENTITY stimulates|nsubj|END_ENTITY	Apelin stimulates both cholecystokinin and glucagon-like_peptide_1 secretions in vitro and in vivo in rodents .
10220557	0	cholecystokinin	94,109	CCK	164,167	cholecystokinin	CCK	MESH:D002766	885	Chemical	Gene	_|compound|START_ENTITY loop|nmod|_ amino_acid|nmod|loop amino_acid|parataxis|confers confers|nmod|END_ENTITY	Single amino_acid substitution of serine82_to_asparagine in first intracellular loop of human cholecystokinin _ -LRB- CCK -RRB- - B_receptor confers full cyclic_AMP responses to CCK and gastrin .
10838169	6	cholecystokinin	917,932	CCK	934,937	cholecystokinin	CCK	MESH:D002766	25298(Tax:10116)	Chemical	Gene	-8|amod|START_ENTITY -8|appos|END_ENTITY	Intact acini were stimulated with cholecystokinin -LRB- CCK -RRB- -8 , carbachol -LRB- CCh -RRB- and the high-affinity CCK-A receptor agonist , CCK-OPE , and the cell lysates were used for REA .
11111008	1	cholecystokinin	196,211	CCK	213,216	cholecystokinin	CCK	MESH:D002766	25298(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Previous studies provided evidence for an interaction between the satiety effects of cholecystokinin -LRB- CCK -RRB- , bombesin -LRB- BBS -RRB- , and amylin .
11739447	0	cholecystokinin	20,35	CCK	160,163	cholecystokinin	CCK	MESH:D002766	885	Chemical	Gene	START_ENTITY|xcomp|-8 -8|nmod|adults adults|dep|evidence evidence|nmod|activity activity|compound|END_ENTITY	Effect of exogenous cholecystokinin -LRB- CCK -RRB- -8 on food intake and plasma CCK , leptin , and insulin concentrations in older and young adults : evidence for increased CCK activity as a cause of the anorexia of aging .
11739447	0	cholecystokinin	20,35	CCK	37,40	cholecystokinin	CCK	MESH:D002766	885	Chemical	Gene	START_ENTITY|xcomp|-8 -8|dep|END_ENTITY	Effect of exogenous cholecystokinin -LRB- CCK -RRB- -8 on food intake and plasma CCK , leptin , and insulin concentrations in older and young adults : evidence for increased CCK activity as a cause of the anorexia of aging .
12106342	1	cholecystokinin	185,200	CCK	424,427	cholecystokinin	CCK	MESH:D002766	25298(Tax:10116)	Chemical	Gene	receptors|nmod|START_ENTITY distribution|nmod|receptors distribution|dep|END_ENTITY	The distribution of receptors for the sulphated octapeptide cholecystokinin 26 - 33 -LRB- CCK - 8S -RRB- in rat brain was investigated by radioligand binding in conjunction with autoradiography using the novel iodinable , non-oxidizable , amino - and thiolendopeptidase-resistant CCK analogue , d-Tyr25 -LRB- Nle28 ,31 -RRB- - CCK 25 - 33S .
12409828	0	cholecystokinin	42,57	CCK	59,62	cholecystokinin	CCK	MESH:D002766	885	Chemical	Gene	stimulation|amod|START_ENTITY stimulation|appos|END_ENTITY	Analysis of duodenal drainage fluid after cholecystokinin -LRB- CCK -RRB- stimulation in healthy volunteers .
1374868	0	cholecystokinin	15,30	CCK	106,109	cholecystokinin	CCK	MESH:D002766	25298(Tax:10116)	Chemical	Gene	Selectivity|nmod|START_ENTITY receptor|nsubj|Selectivity receptor|nmod|sites sites|compound|END_ENTITY	Selectivity of cholecystokinin -LRB- CCK -RRB- receptor antagonists , MK-329 and L-365 ,260 , for axonally-transported CCK binding sites on the rat vagus nerve .
1374868	0	cholecystokinin	15,30	CCK	32,35	cholecystokinin	CCK	MESH:D002766	25298(Tax:10116)	Chemical	Gene	Selectivity|nmod|START_ENTITY Selectivity|appos|END_ENTITY	Selectivity of cholecystokinin -LRB- CCK -RRB- receptor antagonists , MK-329 and L-365 ,260 , for axonally-transported CCK binding sites on the rat vagus nerve .
15056274	0	cholecystokinin	74,89	CCK	91,94	cholecystokinin	CCK	MESH:D002766	12424(Tax:10090)	Chemical	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Genetic inactivation of prohormone convertase -LRB- PC1 -RRB- causes a reduction in cholecystokinin -LRB- CCK -RRB- levels in the hippocampus , amygdala , pons and medulla in mouse brain that correlates with the degree of colocalization of PC1 and CCK mRNA in these structures in rat brain .
15772081	0	cholecystokinin	88,103	CCK	105,108	cholecystokinin	CCK	MESH:D002766	885	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Cross-interactions of two p38 mitogen-activated protein -LRB- MAP -RRB- kinase inhibitors and two cholecystokinin -LRB- CCK -RRB- receptor antagonists with the CCK1 receptor and p38_MAP_kinase .
15980969	0	cholecystokinin	41,56	CCK	58,61	cholecystokinin	CCK	MESH:D002766	885	Chemical	Gene	expressing|nmod|START_ENTITY expressing|dep|END_ENTITY	Meningiomas expressing and responding to cholecystokinin -LRB- CCK -RRB- .
16274843	0	cholecystokinin	58,73	CCK	148,151	cholecystokinin	CCK	MESH:D002766	885	Chemical	Gene	expression|nmod|START_ENTITY Inhibition|nmod|expression decreased|nsubj|Inhibition decreased|dobj|content content|nmod|END_ENTITY	Inhibition of prohormone_convertase_1 -LRB- PC1 -RRB- expression in cholecystokinin -LRB- CCK -RRB- expressing At-T20 cells decreased cellular content and secretion of CCK and caused a shift in molecular forms of CCK secreted .
1683622	0	cholecystokinin	11,26	CCK	28,31	cholecystokinin	CCK	MESH:D002766	885	Chemical	Gene	polypeptide|amod|START_ENTITY polypeptide|appos|END_ENTITY	Effects of cholecystokinin -LRB- CCK -RRB- -8 , CCK-33 , and gastric inhibitory polypeptide -LRB- GIP -RRB- on basal and meal-stimulated pancreatic hormone secretion in man .
16837905	0	cholecystokinin	118,133	CCK	79,82	cholecystokinin	CCK	MESH:D002766	101844223	Chemical	Gene	plasmid|nmod|START_ENTITY plasmid|nsubj|END_ENTITY	Gene therapeutic treatment of pancreatic_cancer based on injection of pcDNA3 .1 / CCK plasmid with xenogeneic homologous cholecystokinin .
1690421	0	cholecystokinin	41,56	CCK	58,61	cholecystokinin	CCK	MESH:D002766	25298(Tax:10116)	Chemical	Gene	maturation|nmod|START_ENTITY thyroxine|nmod|maturation receptors|amod|thyroxine receptors|appos|END_ENTITY	Effect of thyroxine on the maturation of cholecystokinin -LRB- CCK -RRB- receptors in pancreatic acini of neonatal rats .
17150309	8	cholecystokinin	1342,1357	CCK	1444,1447	cholecystokinin	CCK	MESH:D002766	25298(Tax:10116)	Chemical	Gene	were|ccomp|START_ENTITY were|nsubj|+ +|compound|END_ENTITY	The main interneuronal marker expressed by 5-HT -LRB- 3A -RRB- R + neurons was cholecystokinin -LRB- CCK -RRB- , but only 8-16 % of 5-HT -LRB- 3 -RRB- R + neurons in the BLC , depending on the nucleus , were CCK + .
1718434	0	cholecystokinin	11,26	CCK	100,103	cholecystokinin	CCK	MESH:D002766	25298(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY distinguished|nsubj|receptors distinguished|nmod|END_ENTITY	Functional cholecystokinin receptors are distinguished kinetically by biotinyl-Tyr-Gly - -LRB- Thr28 , Nle31 -RRB- CCK -LRB- 25-33 -RRB- in rat pancreatic acini .
1924892	1	cholecystokinin	220,235	CCK	278,281	cholecystokinin	CCK	MESH:D002766	25298(Tax:10116)	Chemical	Gene	elucidate|nmod|START_ENTITY compared|advcl|elucidate compared|dobj|effects effects|nmod|END_ENTITY	To elucidate the regulatory mechanism of acid secretion by cholecystokinin -LRB- CCK -RRB- in vivo , we compared the effects of CCK and gastrin on acid secretion and histidine_decarboxylase -LRB- HDC -RRB- activity .
1982361	0	cholecystokinin	9,24	CCK	26,29	cholecystokinin	CCK	MESH:D002766	25298(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Multiple cholecystokinin -LRB- CCK -RRB- receptors and CCK-monoamine interactions are instrumental in the control of feeding .
231759	0	cholecystokinin	30,45	CCK	163,166	cholecystokinin	CCK	MESH:D002766	12424(Tax:10090)	Chemical	Gene	sites|nmod|START_ENTITY sites|dep|study study|acl|employing employing|nmod|action action|nmod|END_ENTITY	Separate activation sites for cholecystokinin and bombesin on pancreatic acini : an electrophysiological study employing a competitive antagonist for the action of CCK .
25588803	0	cholecystokinin	156,171	CCK	173,176	cholecystokinin	CCK	MESH:D002766	885	Chemical	Gene	provocation|amod|START_ENTITY provocation|appos|END_ENTITY	Management of gallbladder_dyskinesia : patient outcomes following positive -LRB- 99m -RRB- technetium -LRB- Tc -RRB- - labelled hepatic iminodiacetic_acid -LRB- HIDA -RRB- scintigraphy with cholecystokinin -LRB- CCK -RRB- provocation and laparoscopic cholecystectomy .
2578257	0	cholecystokinin	39,54	CCK	24,27	cholecystokinin	CCK	MESH:D002766	100735029	Chemical	Gene	antagonists|amod|START_ENTITY 26-33|nmod|antagonists fragments|dep|26-33 fragments|nmod|END_ENTITY	N-terminal fragments of CCK - -LRB- 26-33 -RRB- as cholecystokinin receptor antagonists in guinea_pig pancreatic acini .
2703143	0	cholecystokinin	25,40	CCK	166,169	cholecystokinin	CCK	MESH:D002766	25298(Tax:10116)	Chemical	Gene	concentrations|nmod|START_ENTITY determined|nsubj|concentrations determined|nmod|method method|acl|based based|nmod|detection detection|nmod|END_ENTITY	Plasma concentrations of cholecystokinin , CCK-8 , and CCK-33 , 39 in rats , determined by a method based on enzyme digestion of gastrin before HPLC and RIA detection of CCK .
2794058	0	cholecystokinin	19,34	CCK	36,39	cholecystokinin	CCK	MESH:D002766	885	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Effects of a novel cholecystokinin -LRB- CCK -RRB- receptor antagonist , MK-329 , on gallbladder contraction and gastric emptying in humans .
2810848	0	cholecystokinin	21,36	CCK	81,84	cholecystokinin	CCK	MESH:D002766	100735029	Chemical	Gene	receptors|compound|START_ENTITY Characterization|nmod|receptors Characterization|dep|effect effect|nmod|analogs analogs|compound|END_ENTITY	-LSB- Characterization of cholecystokinin receptors in gastric chief cells -- effect of CCK analogs and CCK receptor antagonists on chief cells -RSB- .
2983985	0	cholecystokinin	57,72	CCK	74,77	cholecystokinin	CCK	MESH:D002766	25298(Tax:10116)	Chemical	Gene	complex|amod|START_ENTITY complex|appos|END_ENTITY	Solubilization from rat pancreatic plasma membranes of a cholecystokinin -LRB- CCK -RRB- agonist-receptor complex interacting with guanine_nucleotide regulatory proteins coexisting in the same macromolecular system .
3005503	0	cholecystokinin	126,141	CCK	120,123	cholecystokinin	CCK	MESH:D002766	12424(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	A study of the cerebral cortex cholecystokinin receptor using two radiolabelled probes : evidence for a common CCK 8 and CCK 4 cholecystokinin receptor binding site .
3005503	0	cholecystokinin	31,46	CCK	110,113	cholecystokinin	CCK	MESH:D002766	12424(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY study|nmod|receptor study|dep|evidence evidence|nmod|END_ENTITY	A study of the cerebral cortex cholecystokinin receptor using two radiolabelled probes : evidence for a common CCK 8 and CCK 4 cholecystokinin receptor binding site .
3285961	0	cholecystokinin	46,61	CCK	63,66	cholecystokinin	CCK	MESH:D002766	885	Chemical	Gene	projection|amod|START_ENTITY projection|appos|END_ENTITY	Possible target neurons of the reticulospinal cholecystokinin -LRB- CCK -RRB- projection to the lamprey spinal cord : immunohistochemistry combined with intracellular staining with lucifer yellow .
3441450	0	cholecystokinin	65,80	CCK	82,85	cholecystokinin	CCK	MESH:D002766	25298(Tax:10116)	Chemical	Gene	microinjections|nmod|START_ENTITY Effects|nmod|microinjections Effects|appos|END_ENTITY	Effects of unilateral intracerebroventricular microinjections of cholecystokinin -LRB- CCK -RRB- on circling behavior of rats .
3593394	0	cholecystokinin	62,77	CCK	79,82	cholecystokinin	CCK	MESH:D002766	25298(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Characterization of -LSB- 3H -RSB- -LRB- + / - -RRB- L-364 ,718 binding to solubilized cholecystokinin -LRB- CCK -RRB- receptors of rat pancreas .
6199984	0	cholecystokinin	30,45	CCK	15,18	cholecystokinin	CCK	MESH:D002766	100735029	Chemical	Gene	antagonists|amod|START_ENTITY 26-32|nmod|antagonists Derivatives|dep|26-32 Derivatives|nmod|END_ENTITY	Derivatives of CCK - -LRB- 26-32 -RRB- as cholecystokinin receptor antagonists in guinea_pig pancreatic acini .
7106417	0	cholecystokinin	49,64	CCK	66,69	cholecystokinin	CCK	MESH:D002766	885	Chemical	Gene	Iodo-gen|nmod|START_ENTITY Iodination|nmod|Iodo-gen Iodination|appos|END_ENTITY	Iodination with Iodo-gen and radioimmunoassay of cholecystokinin -LRB- CCK -RRB- in acidified plasma , CCK release , and molecular CCK components in man .
7524683	0	cholecystokinin	54,69	CCK	71,74	cholecystokinin	CCK	MESH:D002766	25298(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Characterization of the three different states of the cholecystokinin -LRB- CCK -RRB- receptor in pancreatic acini .
7537612	0	cholecystokinin	36,51	CCK	53,56	cholecystokinin	CCK	MESH:D002766	101116683	Chemical	Gene	infusions|nmod|START_ENTITY Effects|nmod|infusions Effects|appos|END_ENTITY	Effects of intravenous infusions of cholecystokinin -LRB- CCK -RRB- -8 on exocrine and endocrine pancreatic secretion in conscious sheep .
7680902	0	cholecystokinin	27,42	CCK	44,47	cholecystokinin	CCK	MESH:D002766	885	Chemical	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Occupation of low-affinity cholecystokinin -LRB- CCK -RRB- receptors by CCK activates signal transduction and stimulates amylase secretion in pancreatic acinar cells .
7680902	0	cholecystokinin	27,42	CCK	62,65	cholecystokinin	CCK	MESH:D002766	885	Chemical	Gene	receptors|compound|START_ENTITY receptors|nmod|END_ENTITY	Occupation of low-affinity cholecystokinin -LRB- CCK -RRB- receptors by CCK activates signal transduction and stimulates amylase secretion in pancreatic acinar cells .
7716134	0	cholecystokinin	12,27	CCK	29,32	cholecystokinin	CCK	MESH:D002766	25298(Tax:10116)	Chemical	Gene	antagonist|amod|START_ENTITY antagonist|appos|END_ENTITY	Effect of a cholecystokinin -LRB- CCK -RRB- antagonist -LRB- CR 1505 -RRB- on gene expressions of CCK and secretin in rat intestine .
7716134	0	cholecystokinin	12,27	CCK	78,81	cholecystokinin	CCK	MESH:D002766	25298(Tax:10116)	Chemical	Gene	antagonist|amod|START_ENTITY Effect|nmod|antagonist Effect|nmod|expressions expressions|nmod|END_ENTITY	Effect of a cholecystokinin -LRB- CCK -RRB- antagonist -LRB- CR 1505 -RRB- on gene expressions of CCK and secretin in rat intestine .
7760584	0	cholecystokinin	139,154	CCK	156,159	cholecystokinin	CCK	MESH:D002766	25298(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Pretreatment with the 5-HT1A receptor agonists 8-OH-DPAT or gepirone does not attenuate the inhibitory effect of systemically administered cholecystokinin -LRB- CCK -RRB- on food intake in rats .
7911992	0	cholecystokinin	40,55	CCK	80,83	cholecystokinin	CCK	MESH:D002766	609547(Tax:9615)	Chemical	Gene	START_ENTITY|dobj|receptors receptors|compound|END_ENTITY	Somatostatin is released in response to cholecystokinin by activation of type A CCK receptors .
7948036	0	cholecystokinin	60,75	CCK	77,80	cholecystokinin	CCK	MESH:D002766	25298(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Biochemical regulation of the three different states of the cholecystokinin -LRB- CCK -RRB- receptor in pancreatic acini .
8500203	0	cholecystokinin	197,212	CCK	214,217	cholecystokinin	CCK	MESH:D002766	885	Chemical	Gene	-12|compound|START_ENTITY -12|appos|END_ENTITY	Evaluation of the final deprotection system for the solid-phase synthesis of Tyr -LRB- SO3H -RRB- - containing peptides with 9-fluorenylmethyloxycarbonyl -LRB- Fmoc -RRB- - strategy and its application to the synthesis of cholecystokinin -LRB- CCK -RRB- -12 .
8749225	0	cholecystokinin	30,45	CCK	47,50	cholecystokinin	CCK	MESH:D002766	397468(Tax:9823)	Chemical	Gene	administration|nmod|START_ENTITY administration|appos|END_ENTITY	Intravenous administration of cholecystokinin -LRB- CCK -RRB- stimulates prolactin and growth hormone release in the pig .
8899801	0	cholecystokinin	33,48	CCK	50,53	cholecystokinin	CCK	MESH:D002766	25298(Tax:10116)	Chemical	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Autoradiographic localization of cholecystokinin -LRB- CCK -RRB- receptor expression during the development of azaserine-induced rat pancreatic_carcinoma .
8933358	1	cholecystokinin	129,144	CCK	146,149	cholecystokinin	CRF	MESH:D002766	1392	Chemical	Gene	administration|nmod|START_ENTITY administration|appos|END_ENTITY	Systemic administration of cholecystokinin -LRB- CCK -RRB- stimulates neurosecretory oxytocin -LRB- OT -RRB- and tuberoinfundibular corticotrophin_releasing_factor -LRB- CRF -RRB- cells of the hypothalamus .
9972053	0	cholecystokinin	57,72	CCK	74,77	cholecystokinin	CCK	MESH:D002766	25298(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY nitric_oxide|nmod|effects Involvement|nmod|nitric_oxide Involvement|appos|END_ENTITY	Involvement of nitric_oxide in cardiovascular effects of cholecystokinin -LRB- CCK -RRB- in rats .
1606183	0	cholecystokinin	34,49	CCK-B	60,65	cholecystokinin	CCK-B	MESH:D002766	887	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Determination of L-365 ,260 , a new cholecystokinin receptor -LRB- CCK-B -RRB- antagonist , in plasma by liquid chromatography/atmospheric pressure chemical ionization mass spectrometry .
8831778	0	cholecystokinin	217,232	CCK-B	269,274	cholecystokinin	CCK-B	MESH:D002766	887	Chemical	Gene	Nle-Asp-Phe-NH2|appos|START_ENTITY use|dep|Nle-Asp-Phe-NH2 analogue|nsubj|use analogue|nmod|receptors receptors|amod|END_ENTITY	The use of topographical constraints in receptor mapping : investigation of the topographical requirements of the tryptophan 30 residue for receptor binding of Asp-Tyr-D-Phe-Gly-Trp - -LRB- N-Me -RRB- Nle-Asp-Phe-NH2 -LRB- SNF_9007 -RRB- , a cholecystokinin -LRB- 26-33 -RRB- analogue that binds to both CCK-B and delta-opioid receptors .
15772081	0	cholecystokinin	88,103	CCK1	140,144	cholecystokinin	CCK1	MESH:D002766	56477	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|nmod|receptor receptor|compound|END_ENTITY	Cross-interactions of two p38 mitogen-activated protein -LRB- MAP -RRB- kinase inhibitors and two cholecystokinin -LRB- CCK -RRB- receptor antagonists with the CCK1 receptor and p38_MAP_kinase .
11018115	0	cholecystokinin	19,34	Ca2	74,77	cholecystokinin	Ca2	MESH:D002766	760	Chemical	Gene	secretion|compound|START_ENTITY secretion|nmod|END_ENTITY	Fatty_acid-induced cholecystokinin secretion and changes in intracellular Ca2 + in two enteroendocrine cell lines , STC-1 and GLUTag .
18691347	0	cholecystokinin	56,71	Calcium-sensing_receptor	0,24	cholecystokinin	Calcium-sensing receptor	MESH:D002766	12374(Tax:10090)	Chemical	Gene	secretion|compound|START_ENTITY mediates|dobj|secretion mediates|nsubj|END_ENTITY	Calcium-sensing_receptor mediates phenylalanine-induced cholecystokinin secretion in enteroendocrine STC-1 cells .
26920055	0	cholecystokinin	22,37	Nesfatin-1	0,10	cholecystokinin	Nesfatin-1	MESH:D002766	53322(Tax:10090)	Chemical	Gene	stimulates|dobj|START_ENTITY stimulates|nsubj|END_ENTITY	Nesfatin-1 stimulates cholecystokinin and suppresses peptide_YY expression and secretion in mice .
16274843	0	cholecystokinin	58,73	PC1	39,42	cholecystokinin	PC1	MESH:D002766	5122	Chemical	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Inhibition of prohormone_convertase_1 -LRB- PC1 -RRB- expression in cholecystokinin -LRB- CCK -RRB- expressing At-T20 cells decreased cellular content and secretion of CCK and caused a shift in molecular forms of CCK secreted .
8843778	0	cholecystokinin	62,77	Pituitary_adenylate_cyclase-activating_polypeptide	0,50	cholecystokinin	Pituitary adenylate cyclase-activating polypeptide	MESH:D002766	11516(Tax:10090)	Chemical	Gene	secretion|compound|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Pituitary_adenylate_cyclase-activating_polypeptide stimulates cholecystokinin secretion in STC-1 cells .
9083084	0	cholecystokinin	58,73	Prohormone_convertase_1	0,23	cholecystokinin	Prohormone convertase 1	MESH:D002766	18548(Tax:10090)	Chemical	Gene	formation|nmod|START_ENTITY necessary|nmod|formation necessary|nsubj|END_ENTITY	Prohormone_convertase_1 is necessary for the formation of cholecystokinin 8 in Rin5F and STC-1 cells .
9703961	0	cholecystokinin	54,69	Prohormone_convertase_1	0,23	cholecystokinin	Prohormone convertase 1	MESH:D002766	25204(Tax:10116)	Chemical	Gene	expressed|nmod|START_ENTITY END_ENTITY|advcl|expressed	Prohormone_convertase_1 -LRB- PC1 -RRB- when expressed with pro cholecystokinin -LRB- pro CCK -RRB- in L cells performs three endoproteolytic cleavages which are observed in rat brain and in CCK-expressing endocrine cells in culture , including the production of glycine and arginine extended CCK8 .
21901370	0	cholecystokinin	99,114	STC-1	126,131	cholecystokinin	STC-1	MESH:D002766	6781	Chemical	Gene	release|compound|START_ENTITY release|nmod|cells cells|compound|END_ENTITY	Characterization and identification of a chymotryptic hydrolysate of alpha-lactalbumin stimulating cholecystokinin release in STC-1 cells .
26009448	0	cholecystokinin	71,86	STC-1	130,135	cholecystokinin	STC-1	MESH:D002766	6781	Chemical	Gene	secretion|compound|START_ENTITY stimulate|dobj|secretion stimulate|nmod|END_ENTITY	Calcium-sensing_receptor is a sensor for dietary peptides to stimulate cholecystokinin secretion in the enteroendocrine cell line STC-1 .
2465985	0	cholecystokinin	139,154	VIP	202,205	cholecystokinin	VIP	MESH:D002766	7432	Chemical	Gene	neurotensin|dep|START_ENTITY neurotensin|dep|END_ENTITY	Chronic_pancreatitis and diabetes_mellitus : plasma and gastroduodenal_mucosal profiles of regulatory peptides -LRB- gastrin , motilin , secretin , cholecystokinin , gastric inhibitory polypeptide , somatostatin , VIP , substance_P , pancreatic_polypeptide , glucagon , enteroglucagon , neurotensin -RRB- .
7958672	0	cholecystokinin	63,78	bombesin	108,116	cholecystokinin	bombesin	MESH:D002766	2922	Chemical	Gene	inactivation|nmod|START_ENTITY inactivation|nmod|END_ENTITY	Effect of bile_salt binding or protease inactivation on plasma cholecystokinin and gallbladder responses to bombesin .
9539666	0	cholecystokinin	7,22	bombesin	72,80	cholecystokinin	bombesin	MESH:D002766	2922	Chemical	Gene	START_ENTITY|nmod|doses doses|nmod|END_ENTITY	Plasma cholecystokinin and gallbladder responses to increasing doses of bombesin in celiac_disease .
8131259	0	cholecystokinin	10,25	cFos	36,40	cholecystokinin	cFos	MESH:D002766	314322(Tax:10116)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|amod|END_ENTITY	Exogenous cholecystokinin activates cFos expression in medullary but not hypothalamic neurons in neonatal rats .
8132858	0	cholecystokinin	135,150	cFos	91,95	cholecystokinin	cFos	MESH:D002766	314322(Tax:10116)	Chemical	Gene	administration|nmod|START_ENTITY END_ENTITY|nmod|administration	Distribution and neurochemical phenotypes of caudal medullary neurons activated to express cFos following peripheral administration of cholecystokinin .
2465985	0	cholecystokinin	139,154	gastrin	111,118	cholecystokinin	gastrin	MESH:D002766	2520	Chemical	Gene	neurotensin|dep|START_ENTITY END_ENTITY|appos|neurotensin	Chronic_pancreatitis and diabetes_mellitus : plasma and gastroduodenal_mucosal profiles of regulatory peptides -LRB- gastrin , motilin , secretin , cholecystokinin , gastric inhibitory polypeptide , somatostatin , VIP , substance_P , pancreatic_polypeptide , glucagon , enteroglucagon , neurotensin -RRB- .
2579868	8	cholecystokinin	1071,1086	gastrin	1052,1059	cholecystokinin	motilin	MESH:D002766	4295	Chemical	Gene	polypeptide|dep|START_ENTITY polypeptide|compound|END_ENTITY	Blood samples were taken serially for radioimmunoassays of gastrin , secretin , cholecystokinin , pancreatic_polypeptide , gastric inhibitory polypeptide , vasoactive intestinal polypeptide , motilin , and somatostatin .
2703143	0	cholecystokinin	25,40	gastrin	125,132	cholecystokinin	gastrin	MESH:D002766	25320(Tax:10116)	Chemical	Gene	concentrations|nmod|START_ENTITY determined|nsubj|concentrations determined|nmod|method method|acl|based based|nmod|digestion digestion|nmod|END_ENTITY	Plasma concentrations of cholecystokinin , CCK-8 , and CCK-33 , 39 in rats , determined by a method based on enzyme digestion of gastrin before HPLC and RIA detection of CCK .
2856638	0	cholecystokinin	112,127	gastrin	149,156	cholecystokinin	gastrin	MESH:D002766	2520	Chemical	Gene	cerulein|compound|START_ENTITY END_ENTITY|compound|cerulein	Conformational analysis of possible biologically active -LRB- receptor-bound -RRB- conformations of peptides derived from cholecystokinin , cerulein and little gastrin and the opiate peptide , Met-enkephalin .
3594240	0	cholecystokinin	43,58	gastrin	34,41	cholecystokinin	gastrin	MESH:D002766	25320(Tax:10116)	Chemical	Gene	intestinal|dep|START_ENTITY intestinal|compound|END_ENTITY	Effects of preoptic injections of gastrin , cholecystokinin , secretin , vasoactive intestinal peptide and PHI on the secretion of luteinizing hormone and prolactin in ovariectomized estrogen-primed rats .
3779398	0	cholecystokinin	58,73	gastrin	75,82	cholecystokinin	gastrin	MESH:D002766	25320(Tax:10116)	Chemical	Gene	microelectrophoresis|nmod|START_ENTITY responses|nmod|microelectrophoresis responses|appos|END_ENTITY	Septal-preoptic unit responses to microelectrophoresis of cholecystokinin , gastrin , vasoactive intestinal peptide and secretin in the rat .
7429291	0	cholecystokinin	46,61	gastrin	27,34	cholecystokinin	gastrin	MESH:D002766	2520	Chemical	Gene	glucagon|dep|START_ENTITY glucagon|compound|END_ENTITY	Effect of a combination of gastrin , secretin , cholecystokinin , glucagon , and gastric inhibitory polypeptide on jejunal absorption in man .
7489932	0	cholecystokinin	69,84	gastrin	101,108	cholecystokinin	gastrin	MESH:D002766	2520	Chemical	Gene	effect|nmod|START_ENTITY restores|dobj|effect restores|nmod|release release|compound|END_ENTITY	Eradication of Helicobacter_pylori restores the inhibitory effect of cholecystokinin on postprandial gastrin release in duodenal_ulcer patients .
7533864	0	cholecystokinin	20,35	gastrin	174,181	cholecystokinin	gastrin	MESH:D002766	25320(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY Characterization|nmod|receptors Characterization|dep|evidence evidence|nmod|expression expression|nmod|receptors receptors|nmod|receptors receptors|appos|END_ENTITY	Characterization of cholecystokinin receptors and messenger RNA expression in rat pancreas : evidence for expression of cholecystokinin-A receptors but not cholecystokinin-B -LRB- gastrin -RRB- receptors .
8105080	0	cholecystokinin	65,80	gastrin	56,63	cholecystokinin	gastrin	MESH:D002766	2520	Chemical	Gene	insulin|dep|START_ENTITY insulin|compound|END_ENTITY	The relationships between personality traits and plasma gastrin , cholecystokinin , somatostatin , insulin , and oxytocin levels in healthy women .
8238515	0	cholecystokinin	33,48	gastrin	19,26	cholecystokinin	gastrin	MESH:D002766	100345451(Tax:9986)	Chemical	Gene	secretion|compound|START_ENTITY END_ENTITY|nmod|secretion	Partial agonism by gastrin for a cholecystokinin receptor mediating pepsinogen secretion .
6097442	0	cholecystokinin	23,38	growth_hormone	55,69	cholecystokinin	growth hormone	MESH:D002766	81668(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|secretion secretion|compound|END_ENTITY	Suppressive effects of cholecystokinin and bombesin on growth_hormone and prolactin secretion in urethane-anesthetized rats .
7887916	0	cholecystokinin	70,85	pancreatic_cholesterol_esterase	101,132	cholecystokinin	pancreatic cholesterol esterase	MESH:D002766	24254(Tax:10116)	Chemical	Gene	stimulation|compound|START_ENTITY stimulation|nmod|secretion secretion|amod|END_ENTITY	Calcium mobilization and protein kinase C activation are required for cholecystokinin stimulation of pancreatic_cholesterol_esterase secretion .
2465985	0	cholecystokinin	139,154	pancreatic_polypeptide	220,242	cholecystokinin	pancreatic polypeptide	MESH:D002766	5539	Chemical	Gene	neurotensin|dep|START_ENTITY neurotensin|dep|END_ENTITY	Chronic_pancreatitis and diabetes_mellitus : plasma and gastroduodenal_mucosal profiles of regulatory peptides -LRB- gastrin , motilin , secretin , cholecystokinin , gastric inhibitory polypeptide , somatostatin , VIP , substance_P , pancreatic_polypeptide , glucagon , enteroglucagon , neurotensin -RRB- .
7419006	0	cholecystokinin	59,74	pancreatic_polypeptide	11,33	cholecystokinin	pancreatic polypeptide	MESH:D002766	5539	Chemical	Gene	Release|nmod|START_ENTITY Release|nmod|END_ENTITY	Release of pancreatic_polypeptide in humans by infusion of cholecystokinin .
8238515	0	cholecystokinin	33,48	pepsinogen	68,78	cholecystokinin	pepsinogen	MESH:D002766	100328625(Tax:9986)	Chemical	Gene	secretion|compound|START_ENTITY secretion|compound|END_ENTITY	Partial agonism by gastrin for a cholecystokinin receptor mediating pepsinogen secretion .
16274843	0	cholecystokinin	58,73	prohormone_convertase_1	14,37	cholecystokinin	prohormone convertase 1	MESH:D002766	5122	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Inhibition of prohormone_convertase_1 -LRB- PC1 -RRB- expression in cholecystokinin -LRB- CCK -RRB- expressing At-T20 cells decreased cellular content and secretion of CCK and caused a shift in molecular forms of CCK secreted .
9208565	0	cholecystokinin	11,26	prolactin	30,39	cholecystokinin	prolactin	MESH:D002766	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	-LSB- Effect of cholecystokinin on prolactin release and its action mechanism in the rats -RSB- .
3594240	0	cholecystokinin	43,58	secretin	60,68	cholecystokinin	secretin	MESH:D002766	24769(Tax:10116)	Chemical	Gene	intestinal|dep|START_ENTITY intestinal|dep|END_ENTITY	Effects of preoptic injections of gastrin , cholecystokinin , secretin , vasoactive intestinal peptide and PHI on the secretion of luteinizing hormone and prolactin in ovariectomized estrogen-primed rats .
7429291	0	cholecystokinin	46,61	secretin	36,44	cholecystokinin	secretin	MESH:D002766	6343	Chemical	Gene	glucagon|dep|START_ENTITY glucagon|dep|END_ENTITY	Effect of a combination of gastrin , secretin , cholecystokinin , glucagon , and gastric inhibitory polypeptide on jejunal absorption in man .
952277	0	cholecystokinin	61,76	secretin	82,90	cholecystokinin	secretin	MESH:D002766	6343	Chemical	Gene	START_ENTITY|nmod|infusion infusion|compound|END_ENTITY	Similar sensitivities of pancreatic and biliary secretion to cholecystokinin plus secretin infusion .
2465985	0	cholecystokinin	139,154	substance_P	207,218	cholecystokinin	substance P	MESH:D002766	6863	Chemical	Gene	neurotensin|dep|START_ENTITY neurotensin|dep|END_ENTITY	Chronic_pancreatitis and diabetes_mellitus : plasma and gastroduodenal_mucosal profiles of regulatory peptides -LRB- gastrin , motilin , secretin , cholecystokinin , gastric inhibitory polypeptide , somatostatin , VIP , substance_P , pancreatic_polypeptide , glucagon , enteroglucagon , neurotensin -RRB- .
7912895	0	cholecystokinin	71,86	tyrosine_kinase	25,40	cholecystokinin	tyrosine kinase	MESH:D002766	59109(Tax:10116)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of pancreatic tyrosine_kinase and phosphatase activities by cholecystokinin and somatostatin .
9013214	0	cholecystokinin-A	61,78	cholecystokinin-B_receptor	86,112	cholecystokinin-A	cholecystokinin-B receptor	null	12426(Tax:10090)	Chemical	Gene	mechanisms|amod|START_ENTITY mechanisms|amod|END_ENTITY	Caerulein may potentiate morphine-induced antinociception by cholecystokinin-A and/or cholecystokinin-B_receptor mechanisms .
11961341	0	cholecystokinin-B	10,27	gastrin	28,35	cholecystokinin-B	gastrin	null	14459(Tax:10090)	Chemical	Gene	blockade|amod|START_ENTITY blockade|compound|END_ENTITY	Effect of cholecystokinin-B gastrin receptor blockade on chemically induced colon_carcinogenesis in mice : follow-up at 52 weeks .
7533864	0	cholecystokinin-B	155,172	gastrin	174,181	cholecystokinin-B	gastrin	null	25320(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Characterization of cholecystokinin receptors and messenger RNA expression in rat pancreas : evidence for expression of cholecystokinin-A receptors but not cholecystokinin-B -LRB- gastrin -RRB- receptors .
7520502	0	cholecystokinin-octapeptide	82,109	VIP	142,145	cholecystokinin-octapeptide	VIP	MESH:D012844	7432	Chemical	Gene	peptide|amod|START_ENTITY peptide|appos|END_ENTITY	Regulation of gap junctional coupling in isolated pancreatic acinar cell pairs by cholecystokinin-octapeptide , vasoactive intestinal peptide -LRB- VIP -RRB- and a VIP-antagonist .
20680358	0	cholecystokinin-octapeptide	51,78	c-fos	97,102	cholecystokinin-octapeptide	c-fos	MESH:D012844	314322(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Repeated administration of methamphetamine blocked cholecystokinin-octapeptide injection-induced c-fos mRNA expression without change in capsaicin-induced junD mRNA expression in rat cerebellum .
705248	0	cholecystokinin-pancreozymin	72,100	secretin	25,33	cholecystokinin-pancreozymin	secretin	null	100733638	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The inhibitory effect of secretin and glucagon on pressure responses to cholecystokinin-pancreozymin in isolated guinea-pig stomach .
11457531	0	cholecystokinin-tetrapeptide	46,74	Arginine-vasopressin_and_oxytocin	0,33	cholecystokinin-tetrapeptide	Arginine-vasopressin and oxytocin	MESH:D013758	551;5020	Chemical	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Arginine-vasopressin_and_oxytocin response to cholecystokinin-tetrapeptide .
22414867	0	cholecystokinin-tetrapeptide	36,64	CCK-B_receptor	0,14	cholecystokinin-tetrapeptide	CCK-B receptor	MESH:D013758	887	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	CCK-B_receptor gene and response to cholecystokinin-tetrapeptide in healthy volunteers .
9298521	0	cholecystokinin_B	63,80	gastrin	81,88	cholecystokinin B	gastrin	null	25320(Tax:10116)	Chemical	Gene	blockade|compound|START_ENTITY blockade|compound|END_ENTITY	Time-course of deactivation of rat stomach ECL cells following cholecystokinin_B / gastrin receptor blockade .
8216742	0	cholecystokinin_octapeptide	27,54	CCK-B_receptor	126,140	cholecystokinin octapeptide	CCK-B receptor	MESH:D012844	887	Chemical	Gene	effect|nmod|START_ENTITY mediated|nsubjpass|effect mediated|nmod|END_ENTITY	The antagonistic effect of cholecystokinin_octapeptide -LRB- CCK-8 -RRB- on opioid effects in cardiovascular activities was mediated by CCK-B_receptor .
6151935	0	cholecystokinin_octapeptide	32,59	growth_hormone	78,92	cholecystokinin octapeptide	growth hormone	MESH:D012844	81668(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	In vivo and in vitro effects of cholecystokinin_octapeptide on the release of growth_hormone in rats .
4018718	0	cholecystokinin_octapeptide	32,59	prolactin	78,87	cholecystokinin octapeptide	prolactin	MESH:D012844	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	In vivo and in vitro effects of cholecystokinin_octapeptide on the release of prolactin in rats .
12174385	0	cholecystokinin_octapeptide	10,37	tumor_necrosis_factor_alpha	41,68	cholecystokinin octapeptide	tumor necrosis factor alpha	MESH:D012844	24835(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|transcription transcription|compound|END_ENTITY	Effect of cholecystokinin_octapeptide on tumor_necrosis_factor_alpha transcription and nuclear factor-kappaB activity induced by lipopolysaccharide in rat pulmonary interstitial macrophages .
8510808	0	cholecystokinin_octapeptide_sulfate_ester	109,150	corticotropin-releasing_factor	19,49	cholecystokinin octapeptide sulfate ester	corticotropin-releasing factor	null	81648(Tax:10116)	Chemical	Gene	Role|acl|START_ENTITY Role|nmod|END_ENTITY	Role of endogenous corticotropin-releasing_factor in mediation of neuroendocrine and behavioral responses to cholecystokinin_octapeptide_sulfate_ester in rats .
22733410	0	cholestan_disulfate	64,83	pregnane-X-receptor	96,115	cholestan disulfate	pregnane-X-receptor	null	8856	Chemical	Gene	START_ENTITY|nmod|agonist agonist|amod|END_ENTITY	Modification in the side chain of solomonsterol_A : discovery of cholestan_disulfate as a potent pregnane-X-receptor agonist .
8375418	0	cholesterol	45,56	A-II_and_C-I	29,41	cholesterol	A-II and C-I	MESH:D002784	114548	Chemical	Gene	efflux|compound|START_ENTITY END_ENTITY|nmod|efflux	Role of apolipoproteins A-I , A-II_and_C-I in cholesterol efflux from endothelial and smooth muscle cells .
10918070	0	cholesterol	66,77	ABCA1	0,5	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	secretion|compound|START_ENTITY mediates|dobj|secretion receptor|acl:relcl|mediates receptor|nsubj|END_ENTITY	ABCA1 is the cAMP-inducible apolipoprotein receptor that mediates cholesterol secretion from macrophages .
10938021	0	cholesterol	52,63	ABCA1	16,21	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	HDL|dobj|START_ENTITY HDL|nsubj|variants variants|compound|END_ENTITY	Common and rare ABCA1 variants affecting plasma HDL cholesterol .
10998475	0	cholesterol	19,30	ABCA1	106,111	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	efflux|compound|START_ENTITY cause|nsubj|efflux cause|dep|role role|nmod|mutations mutations|compound|END_ENTITY	Decreased cellular cholesterol efflux is a common cause of familial_hypoalphalipoproteinemia : role of the ABCA1 gene mutations .
11086027	0	cholesterol	47,58	ABCA1	97,102	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	levels|compound|START_ENTITY affect|dobj|levels affect|nmod|heterozygotes heterozygotes|nummod|END_ENTITY	Age and residual cholesterol efflux affect HDL cholesterol levels and coronary_artery_disease in ABCA1 heterozygotes .
11135616	0	cholesterol	44,55	ABCA1	124,129	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	removal|compound|START_ENTITY induce|dobj|removal induce|nmod|stimulation stimulation|nmod|pathway pathway|compound|END_ENTITY	PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway .
11213089	0	cholesterol	18,29	ABCA1	43,48	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Regulation of the cholesterol efflux gene , ABCA1 .
11309399	0	cholesterol	59,70	ABCA1	37,42	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	as|nmod:npmod|START_ENTITY efflux|advmod|as efflux|nsubj|functions functions|appos|END_ENTITY	ATP-binding_cassette_transporter_A1 -LRB- ABCA1 -RRB- functions as a cholesterol efflux regulatory protein .
11423537	0	cholesterol	72,83	ABCA1	6,11	cholesterol	ABCA1	MESH:D002784	11303(Tax:10090)	Chemical	Gene	increased|dobj|START_ENTITY increased|nsubj|show show|compound|END_ENTITY	Human ABCA1 BAC transgenic_mice show increased high density lipoprotein cholesterol and ApoAI-dependent efflux stimulated by an internal promoter containing liver X receptor response elements in intron 1 .
11714841	0	cholesterol	33,44	ABCA1	16,21	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|nmod|transport	Pivotal role of ABCA1 in reverse cholesterol transport influencing HDL levels and susceptibility to atherosclerosis .
11790770	0	cholesterol	54,65	ABCA1	86,91	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	effective|nmod|START_ENTITY effective|ccomp|loading loading|advcl|inducing inducing|dobj|mRNA mRNA|compound|END_ENTITY	A potent synthetic LXR agonist is more effective than cholesterol loading at inducing ABCA1 mRNA and stimulating cholesterol efflux .
12009425	0	cholesterol	49,60	ABCA1	6,11	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	deficiency|compound|START_ENTITY associated|nmod|deficiency associated|nsubj|variant variant|compound|END_ENTITY	Novel ABCA1 compound variant associated with HDL cholesterol deficiency .
12069757	0	cholesterol	4,15	ABCA1	39,44	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	START_ENTITY|acl|mobilizing mobilizing|dobj|END_ENTITY	The cholesterol mobilizing transporter ABCA1 as a new therapeutic target for cardiovascular_disease .
12153993	0	cholesterol	69,80	ABCA1	21,26	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	absorption|compound|START_ENTITY decrease|nmod|absorption contributes|nmod|decrease contributes|nsubj|expression expression|compound|END_ENTITY	Increased intestinal ABCA1 expression contributes to the decrease in cholesterol absorption after plant stanol consumption .
12181325	0	cholesterol	67,78	ABCA1	127,132	cholesterol	ABCA1	MESH:D002784	11303(Tax:10090)	Chemical	Gene	efflux|compound|START_ENTITY efflux|nmod|END_ENTITY	The role of apolipoprotein_A-I helix 10 in apolipoprotein-mediated cholesterol efflux via the ATP-binding cassette transporter ABCA1 .
12401885	0	cholesterol	14,25	ABCA1	121,126	cholesterol	ABCA1	MESH:D002784	11303(Tax:10090)	Chemical	Gene	absorption|compound|START_ENTITY Inhibition|nmod|absorption mediated|nsubjpass|Inhibition mediated|nmod|changes changes|nmod|expression expression|nmod|mRNA mRNA|nmod|END_ENTITY	Inhibition of cholesterol absorption by SCH_58053 in the mouse is not mediated via changes in the expression of mRNA for ABCA1 , ABCG5 , or ABCG8 in the enterocyte .
12551894	0	cholesterol	112,123	ABCA1	96,101	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	efflux|compound|START_ENTITY A1|dep|efflux A1|appos|END_ENTITY	Secretory vesicular transport from the Golgi is altered during ATP-binding cassette protein A1 -LRB- ABCA1 -RRB- - mediated cholesterol efflux .
12551945	0	cholesterol	45,56	ABCA1	0,5	cholesterol	ABCA1	MESH:D002784	373945(Tax:9031)	Chemical	Gene	efflux|compound|START_ENTITY essential|nmod|efflux essential|nsubj|END_ENTITY	ABCA1 is essential for efficient basolateral cholesterol efflux during the absorption of dietary cholesterol in chickens .
12551945	0	cholesterol	97,108	ABCA1	0,5	cholesterol	ABCA1	MESH:D002784	373945(Tax:9031)	Chemical	Gene	absorption|nmod|START_ENTITY efflux|nmod|absorption essential|nmod|efflux essential|nsubj|END_ENTITY	ABCA1 is essential for efficient basolateral cholesterol efflux during the absorption of dietary cholesterol in chickens .
12576511	0	cholesterol	65,76	ABCA1	20,25	cholesterol	ABCA1	MESH:D002784	11303(Tax:10090)	Chemical	Gene	modulating|dobj|START_ENTITY transporter|acl|modulating transporter|compound|END_ENTITY	Role of the hepatic ABCA1 transporter in modulating intrahepatic cholesterol and plasma HDL cholesterol concentrations .
12576511	0	cholesterol	92,103	ABCA1	20,25	cholesterol	ABCA1	MESH:D002784	11303(Tax:10090)	Chemical	Gene	concentrations|compound|START_ENTITY HDL|dobj|concentrations HDL|nsubj|Role Role|nmod|transporter transporter|compound|END_ENTITY	Role of the hepatic ABCA1 transporter in modulating intrahepatic cholesterol and plasma HDL cholesterol concentrations .
12595494	0	cholesterol	126,137	ABCA1	120,125	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	efflux|compound|START_ENTITY efflux|compound|END_ENTITY	PPAR agonists protect mesangial cells from interleukin_1beta-induced intracellular lipid accumulation by activating the ABCA1 cholesterol efflux pathway .
12600718	0	cholesterol	20,31	ABCA1	0,5	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	levels|compound|START_ENTITY modulates|dobj|levels modulates|nsubj|END_ENTITY	ABCA1 modulates CSF cholesterol levels and influences the age at onset of Alzheimer 's _ disease .
12700343	0	cholesterol	29,40	ABCA1	0,5	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	independent|compound|START_ENTITY redistributes|dobj|independent redistributes|nsubj|END_ENTITY	ABCA1 redistributes membrane cholesterol independent of apolipoprotein interactions .
12740222	0	cholesterol	26,37	ABCA1	8,13	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	efflux|compound|START_ENTITY Role|nmod|efflux Role|nmod|END_ENTITY	Role of ABCA1 in cellular cholesterol efflux and reverse cholesterol transport .
12849976	0	cholesterol	50,61	ABCA1	108,113	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	transport|compound|START_ENTITY stimulates|dobj|transport stimulates|nmod|transcription transcription|compound|END_ENTITY	The bisphosphonate_ibandronate stimulates reverse cholesterol transport out of monocytoid cells by enhanced ABCA1 transcription .
12860256	0	cholesterol	113,124	ABCA1	74,79	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	level|compound|START_ENTITY alters|dobj|level alters|nsubj|variant variant|appos|END_ENTITY	A common Ile_823_Met variant of ATP-binding_cassette_transporter_A1 gene -LRB- ABCA1 -RRB- alters high density lipoprotein cholesterol level in Japanese population .
12921988	0	cholesterol	45,56	ABCA1	6,11	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubj|mutation mutation|compound|END_ENTITY	A new ABCA1 mutation associated with low HDL cholesterol but without coronary_artery_disease .
14617740	0	cholesterol	90,101	ABCA1	0,5	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	efflux|compound|START_ENTITY required|nmod|efflux complexes|acl|required form|dobj|complexes form|nsubj|END_ENTITY	ABCA1 and amphipathic apolipoproteins form high-affinity molecular complexes required for cholesterol efflux .
14644392	0	cholesterol	19,30	ABCA1	68,73	cholesterol	ABCA1	MESH:D002784	11303(Tax:10090)	Chemical	Gene	removed|nsubjpass|START_ENTITY removed|nmod|apoA-I apoA-I|nmod|END_ENTITY	Cytotoxic cellular cholesterol is selectively removed by apoA-I via ABCA1 .
14668333	0	cholesterol	99,110	ABCA1	62,67	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	removing|dobj|START_ENTITY required|advcl|removing END_ENTITY|acl|required	Janus_kinase_2 modulates the apolipoprotein interactions with ABCA1 required for removing cellular cholesterol .
14703508	0	cholesterol	26,37	ABCA1	0,5	cholesterol	ABCA1	MESH:D002784	11303(Tax:10090)	Chemical	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	ABCA1 mediates concurrent cholesterol and phospholipid efflux to apolipoprotein_A-I .
14726413	0	cholesterol	68,79	ABCA1	96,101	cholesterol	ABCA1	MESH:D002784	11303(Tax:10090)	Chemical	Gene	release|nmod|START_ENTITY increases|dobj|release increases|nmod|induction induction|nmod|expression expression|nummod|END_ENTITY	Verapamil increases the apolipoprotein-mediated release of cellular cholesterol by induction of ABCA1 expression via Liver X receptor-independent mechanism .
14767869	0	cholesterol	52,63	ABCA1	127,132	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	Associations|nmod|START_ENTITY Associations|nmod|gene gene|compound|END_ENTITY	Associations between serum high-density lipoprotein cholesterol or apolipoprotein_AI levels and common genetic variants of the ABCA1 gene in Japanese school-aged children .
15231854	0	cholesterol	39,50	ABCA1	70,75	cholesterol	ABCA1	MESH:D002784	11303(Tax:10090)	Chemical	Gene	efflux|compound|START_ENTITY efflux|acl|mediated mediated|nmod|END_ENTITY	Moderate alcohol consumption increases cholesterol efflux mediated by ABCA1 .
15520856	0	cholesterol	52,63	ABCA1	28,33	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	levels|compound|START_ENTITY HDL|dobj|levels contribute|xcomp|HDL contribute|nsubj|variants variants|nmod|END_ENTITY	Do DNA sequence variants in ABCA1 contribute to HDL cholesterol levels in the general population ?
15721011	0	cholesterol	54,65	ABCA1	81,86	cholesterol	ABCA1	MESH:D002784	11303(Tax:10090)	Chemical	Gene	efflux|compound|START_ENTITY efflux|nmod|transporter transporter|compound|END_ENTITY	Paraoxonase_1 -LRB- PON1 -RRB- enhances HDL-mediated macrophage cholesterol efflux via the ABCA1 transporter in association with increased HDL binding to the cells : a possible role for lysophosphatidylcholine .
15845910	0	cholesterol	68,79	ABCA1	21,26	cholesterol	ABCA1	MESH:D002784	11303(Tax:10090)	Chemical	Gene	levels|compound|START_ENTITY decreases|dobj|levels decreases|nsubj|Knockdown Knockdown|nmod|END_ENTITY	Knockdown of hepatic ABCA1 by RNA interference decreases plasma HDL cholesterol levels and influences postprandial_lipemia in mice .
15961705	0	cholesterol	9,20	ABCA1	137,142	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	metabolism|compound|START_ENTITY Genes|nmod|metabolism Genes|dep|overexpression overexpression|acl|promoting promoting|dobj|storage storage|nmod|expression expression|compound|END_ENTITY	Genes of cholesterol metabolism in human atheroma : overexpression of perilipin and genes promoting cholesterol storage and repression of ABCA1 expression .
15961705	0	cholesterol	99,110	ABCA1	137,142	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	storage|compound|START_ENTITY storage|nmod|expression expression|compound|END_ENTITY	Genes of cholesterol metabolism in human atheroma : overexpression of perilipin and genes promoting cholesterol storage and repression of ABCA1 expression .
16107338	0	cholesterol	20,31	ABCA1	166,171	cholesterol	ABCA1	MESH:D002784	11303(Tax:10090)	Chemical	Gene	efflux|compound|START_ENTITY induce|dobj|efflux induce|parataxis|END_ENTITY	Anthocyanins induce cholesterol efflux from mouse peritoneal macrophages : the role of the peroxisome proliferator-activated receptor -LCB- gamma -RCB- - liver X receptor -LCB- alpha -RCB- - ABCA1 pathway .
16157450	0	cholesterol	23,34	ABCA1	60,65	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	genes|compound|START_ENTITY studies|nmod|genes studies|appos|CH25H CH25H|dep|END_ENTITY	Association studies of cholesterol metabolism genes -LRB- CH25H , ABCA1 and CH24H -RRB- in Alzheimer 's _ disease .
16357317	0	cholesterol	37,48	ABCA1	0,5	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	export|compound|START_ENTITY mediate|dobj|export synergize|xcomp|mediate synergize|nsubj|END_ENTITY	ABCA1 and ABCG1 synergize to mediate cholesterol export to apoA-I .
16410457	0	cholesterol	45,56	ABCA1	26,31	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	contributions|nmod|START_ENTITY contributions|nmod|END_ENTITY	Relative contributions of ABCA1 and SR-BI to cholesterol efflux to serum from fibroblasts and macrophages .
16771834	0	cholesterol	24,35	ABCA1	15,20	cholesterol	ABCA1	MESH:D002784	11303(Tax:10090)	Chemical	Gene	efflux|compound|START_ENTITY effects|nmod|efflux effects|nmod|END_ENTITY	The effects of ABCA1 on cholesterol efflux and Abeta levels in vitro and in vivo .
16901265	0	cholesterol	50,61	ABCA1	75,80	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	SREBP-2 positively regulates transcription of the cholesterol efflux gene , ABCA1 , by generating oxysterol ligands for LXR .
16902247	0	cholesterol	61,72	ABCA1	0,5	cholesterol	ABCA1	MESH:D002784	11303(Tax:10090)	Chemical	Gene	remove|dobj|START_ENTITY act|xcomp|remove act|nsubj|END_ENTITY	ABCA1 and ABCG1 or ABCG4 act sequentially to remove cellular cholesterol and generate cholesterol-rich HDL .
16940190	0	cholesterol	128,139	ABCA1	30,35	cholesterol	ABCA1	MESH:D002784	11303(Tax:10090)	Chemical	Gene	levels|compound|START_ENTITY maintenance|nmod|levels have|nmod|maintenance have|nsubj|END_ENTITY	Both hepatic and extrahepatic ABCA1 have discrete and essential functions in the maintenance of plasma high-density lipoprotein cholesterol levels in vivo .
16946132	0	cholesterol	107,118	ABCA1	40,45	cholesterol	ABCA1	MESH:D002784	11303(Tax:10090)	Chemical	Gene	levels|compound|START_ENTITY raises|dobj|levels raises|nsubj|induction induction|nmod|expression expression|compound|END_ENTITY	Tissue-specific induction of intestinal ABCA1 expression with a liver_X_receptor agonist raises plasma HDL cholesterol levels .
17032780	0	cholesterol	29,40	ABCA1	67,72	cholesterol	ABCA1	MESH:D002784	535379(Tax:9913)	Chemical	Gene	Identification|nmod|START_ENTITY efflux|nsubj|Identification efflux|dobj|END_ENTITY	Identification of the bovine cholesterol efflux regulatory protein ABCA1 and its expression in various tissues .
17101031	0	cholesterol	31,42	ABCA1	172,177	cholesterol	ABCA1	MESH:D002784	313210(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY induces|dobj|release induces|nsubj|cells cells|nmod|manner manner|nmod|induction induction|nmod|expression expression|compound|END_ENTITY	24S-hydroxycholesterol induces cholesterol release from choroid plexus epithelial cells in an apical - and apoE isoform-dependent manner concomitantly with the induction of ABCA1 and ABCG1 expression .
17324574	0	cholesterol	23,34	ABCA1	0,5	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	nexus|nmod|START_ENTITY END_ENTITY|nmod|nexus	ABCA1 : at the nexus of cholesterol , HDL and atherosclerosis .
17409096	0	cholesterol	26,37	ABCA1	48,53	cholesterol	ABCA1	MESH:D002784	100761226	Chemical	Gene	efflux|compound|START_ENTITY Enhanced|dobj|efflux Enhanced|nmod|END_ENTITY	Enhanced apoA-I-dependent cholesterol efflux by ABCA1 from sphingomyelin-deficient Chinese_hamster ovary cells .
17466310	0	cholesterol	99,110	ABCA1	25,30	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	levels|compound|START_ENTITY influenced|nmod|levels influenced|nsubjpass|effect effect|nmod|statins statins|nmod|expression expression|compound|END_ENTITY	The effect of statins on ABCA1 and ABCG1 expression in human macrophages is influenced by cellular cholesterol levels and extent of differentiation .
17541020	0	cholesterol	16,27	ABCA1	63,68	cholesterol	ABCA1	MESH:D002784	11303(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY impaired|nmod|transport impaired|csubj|lacking lacking|dobj|expression expression|compound|END_ENTITY	In vivo reverse cholesterol transport from macrophages lacking ABCA1 expression is impaired .
17697528	0	cholesterol	71,82	ABCA1	46,51	cholesterol	ABCA1	MESH:D002784	101838333	Chemical	Gene	efflux|compound|START_ENTITY Study|dep|efflux Study|nmod|ATP-binding_cassette_transporter_A1 ATP-binding_cassette_transporter_A1|appos|END_ENTITY	Study of ATP-binding_cassette_transporter_A1 -LRB- ABCA1 -RRB- - mediated cellular cholesterol efflux in diabetic_golden_hamsters .
18523221	0	cholesterol	90,101	ABCA1	49,54	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	levels|compound|START_ENTITY gene|nmod|levels gene|compound|END_ENTITY	Association of loss-of-function mutations in the ABCA1 gene with high-density lipoprotein cholesterol levels and risk of ischemic_heart_disease .
18775956	0	cholesterol	30,41	ABCA1	53,58	cholesterol	ABCA1	MESH:D002784	11303(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY Characterization|nmod|transport Characterization|parataxis|target target|nsubj|END_ENTITY	Characterization of placental cholesterol transport : ABCA1 is a potential target for in utero therapy of Smith-Lemli-Opitz_syndrome .
18782758	0	cholesterol	73,84	ABCA1	57,62	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	efflux|compound|START_ENTITY modulates|dobj|efflux modulates|nsubj|interaction interaction|nmod|receptor-beta receptor-beta|nmod|END_ENTITY	Direct interaction of nuclear liver X receptor-beta with ABCA1 modulates cholesterol efflux .
18820007	0	cholesterol	20,31	ABCA1	99,104	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	transport|compound|START_ENTITY mediated|nsubjpass|transport mediated|nmod|END_ENTITY	LXR-induced reverse cholesterol transport in human airway smooth muscle is mediated exclusively by ABCA1 .
19070858	0	cholesterol	87,98	ABCA1	30,35	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	efflux|compound|START_ENTITY reduces|dobj|efflux reduces|iobj|phosphorylation phosphorylation|nummod|END_ENTITY	Eicosapentaenoic_acid reduces ABCA1 serine phosphorylation and impairs ABCA1-dependent cholesterol efflux through cyclic_AMP / protein kinase A signaling pathway in THP-1 macrophage-derived foam cells .
19168441	0	cholesterol	69,80	ABCA1	110,115	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	deliver|dobj|START_ENTITY deliver|nmod|circulation circulation|nmod|END_ENTITY	Human endothelial cells of the placental barrier efficiently deliver cholesterol to the fetal circulation via ABCA1 and ABCG1 .
19258317	0	cholesterol	82,93	ABCA1	113,118	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	efflux|compound|START_ENTITY efflux|acl|mediated mediated|nmod|END_ENTITY	Formation of two intramolecular disulfide bonds is necessary for ApoA-I-dependent cholesterol efflux mediated by ABCA1 .
19275878	0	cholesterol	85,96	ABCA1	0,5	cholesterol	ABCA1	MESH:D002784	313210(Tax:10116)	Chemical	Gene	caveolin-1|nmod|START_ENTITY efflux|amod|caveolin-1 exit|nmod|efflux modulates|dobj|exit modulates|nsubj|END_ENTITY	ABCA1 modulates the oligomerization and Golgi exit of caveolin-1 during HDL-mediated cholesterol efflux in aortic endothelial cells .
19286647	0	cholesterol	51,62	ABCA1	0,5	cholesterol	ABCA1	MESH:D002784	11303(Tax:10090)	Chemical	Gene	movement|nmod|START_ENTITY role|nmod|movement plays|dobj|role plays|nsubj|END_ENTITY	ABCA1 plays no role in the centripetal movement of cholesterol from peripheral tissues to the liver and intestine in the mouse .
19295162	0	cholesterol	45,56	ABCA1	23,28	cholesterol	ABCA1	MESH:D002784	11303(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY increases|dobj|uptake increases|nsubj|loss loss|nmod|END_ENTITY	Specific loss of brain ABCA1 increases brain cholesterol uptake and influences neuronal structure and function .
19304587	0	cholesterol	22,33	ABCA1	78,83	cholesterol	ABCA1	MESH:D002784	11303(Tax:10090)	Chemical	Gene	A1|compound|START_ENTITY A1|appos|END_ENTITY	Expression of reverse cholesterol transport proteins ATP-binding cassette A1 -LRB- ABCA1 -RRB- and scavenger_receptor_BI -LRB- SR-BI -RRB- in the retina and retinal pigment epithelium .
19344785	0	cholesterol	9,20	ABCA1	30,35	cholesterol	ABCA1	MESH:D002784	11303(Tax:10090)	Chemical	Gene	exporter|compound|START_ENTITY END_ENTITY|nsubj|exporter	The cell cholesterol exporter ABCA1 as a protector from cardiovascular_disease and diabetes .
19783654	0	cholesterol	15,26	ABCA1	36,41	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	exporter|compound|START_ENTITY exporter|dep|functions functions|nummod|END_ENTITY	The macrophage cholesterol exporter ABCA1 functions as an anti-inflammatory receptor .
20075420	0	cholesterol	121,132	ABCA1	34,39	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	specimens|nmod|START_ENTITY capacity|nmod|specimens determines|dobj|capacity determines|nsubj|ability ability|acl|promote promote|dobj|efflux efflux|nmod|END_ENTITY	The ability to promote efflux via ABCA1 determines the capacity of serum specimens with similar high-density lipoprotein cholesterol to remove cholesterol from macrophages .
20075420	0	cholesterol	143,154	ABCA1	34,39	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	remove|dobj|START_ENTITY determines|xcomp|remove determines|nsubj|ability ability|acl|promote promote|dobj|efflux efflux|nmod|END_ENTITY	The ability to promote efflux via ABCA1 determines the capacity of serum specimens with similar high-density lipoprotein cholesterol to remove cholesterol from macrophages .
20348106	0	cholesterol	77,88	ABCA1	62,67	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	efflux|compound|START_ENTITY induces|dobj|efflux induces|nsubj|Binding Binding|nmod|ATP-binding_cassette_transporter_A1 ATP-binding_cassette_transporter_A1|appos|END_ENTITY	Binding of PDZ-RhoGEF to ATP-binding_cassette_transporter_A1 -LRB- ABCA1 -RRB- induces cholesterol efflux through RhoA activation and prevention of transporter degradation .
20378541	0	cholesterol	105,116	ABCA1	131,136	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	efflux|compound|START_ENTITY efflux|nmod|pathway pathway|compound|END_ENTITY	Modifying apolipoprotein_A-I by malondialdehyde , but not by an array of other reactive carbonyls , blocks cholesterol efflux by the ABCA1 pathway .
20485864	0	cholesterol	103,114	ABCA1	46,51	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	transport|compound|START_ENTITY link|nmod|transport A1|dep|link A1|appos|END_ENTITY	ATP-binding membrane cassette transporter A1 -LRB- ABCA1 -RRB- : a possible link between inflammation and reverse cholesterol transport .
20562425	0	cholesterol	49,60	ABCA1	20,25	cholesterol	ABCA1	MESH:D002784	11303(Tax:10090)	Chemical	Gene	HDL|dobj|START_ENTITY HDL|nsubj|increases increases|compound|END_ENTITY	Hepatocyte-specific ABCA1 transfer increases HDL cholesterol but impairs HDL function and accelerates atherosclerosis .
20570635	0	cholesterol	46,57	ABCA1	10,15	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	efflux|dobj|START_ENTITY transporters|dep|efflux transporters|nsubj|END_ENTITY	Placental ABCA1 and ABCG1 transporters efflux cholesterol and protect trophoblasts from oxysterol induced toxicity .
20650929	0	cholesterol	114,125	ABCA1	11,16	cholesterol	ABCA1	MESH:D002784	11303(Tax:10090)	Chemical	Gene	reduction|nmod|START_ENTITY reduces|nmod|reduction reduces|nsubj|END_ENTITY	Macrophage ABCA1 reduces MyD88-dependent Toll-like receptor trafficking to lipid rafts by reduction of lipid raft cholesterol .
21215399	0	cholesterol	5,16	ABCA1	65,70	cholesterol	ABCA1	MESH:D002784	268379(Tax:10090)	Chemical	Gene	alters|compound|START_ENTITY macrophage|nsubj|alters macrophage|nmod|mechanism mechanism|compound|END_ENTITY	Free cholesterol alters macrophage morphology and mobility by an ABCA1 dependent mechanism .
21338792	0	cholesterol	96,107	ABCA1	18,23	cholesterol	ABCA1	MESH:D002784	535379(Tax:9913)	Chemical	Gene	secretion|compound|START_ENTITY implications|nmod|secretion Identification|dep|implications Identification|nmod|END_ENTITY	Identification of ABCA1 and ABCG1 in milk fat globules and mammary cells -- implications for milk cholesterol secretion .
21507939	0	cholesterol	147,158	ABCA1	81,86	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	accumulation|compound|START_ENTITY promote|nmod|accumulation interacts|xcomp|promote interacts|nmod|A1 A1|appos|END_ENTITY	Liver_X receptor beta -LRB- LXRbeta -RRB- interacts directly with ATP-binding cassette A1 -LRB- ABCA1 -RRB- to promote high density lipoprotein formation during acute cholesterol accumulation .
21605865	0	cholesterol	65,76	ABCA1	85,90	cholesterol	ABCA1	MESH:D002784	313210(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|transporter transporter|compound|END_ENTITY	Thyroid hormone enhances the ability of serum to accept cellular cholesterol via the ABCA1 transporter .
21605865	5	cholesterol	752,763	ABCA1	783,788	cholesterol	ABCG1	MESH:D002784	85264(Tax:10116)	Chemical	Gene	efflux|compound|START_ENTITY efflux|acl|mediated mediated|nmod|END_ENTITY	J774 macrophages , BHK cells , and Fu5AH rat hepatoma cells were used to measure cholesterol efflux mediated by ABCA1 , ABCG1 transporters or SR-BI .
21670559	0	cholesterol	15,26	ABCA1	53,58	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	efflux|compound|START_ENTITY inhibits|dobj|efflux inhibits|nmod|expression expression|compound|END_ENTITY	AOPPs inhibits cholesterol efflux by down-regulating ABCA1 expression in a JAK/STAT signaling pathway-dependent manner .
21672528	0	cholesterol	78,89	ABCA1	104,109	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	efflux|compound|START_ENTITY increases|dobj|efflux increases|nmod|transporter transporter|compound|END_ENTITY	Helix stabilization of amphipathic peptides by hydrocarbon stapling increases cholesterol efflux by the ABCA1 transporter .
21697542	0	cholesterol	45,56	ABCA1	0,5	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	efflux|compound|START_ENTITY mediate|dobj|efflux extracellular|xcomp|mediate extracellular|nsubj|increases increases|compound|END_ENTITY	ABCA1 increases extracellular ATP to mediate cholesterol efflux to ApoA-I .
21875686	0	cholesterol	79,90	ABCA1	111,116	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	START_ENTITY|amod|due due|nmod|mutations mutations|nmod|END_ENTITY	Increased risk of coronary_artery_disease in Caucasians with extremely low HDL cholesterol due to mutations in ABCA1 , APOA1 , and LCAT .
21998401	0	cholesterol	6,17	ABCA1	46,51	cholesterol	ABCA1	MESH:D002784	11303(Tax:10090)	Chemical	Gene	accumulation|compound|START_ENTITY accumulation|amod|due due|nmod|loss loss|nmod|END_ENTITY	Islet cholesterol accumulation due to loss of ABCA1 leads to impaired exocytosis of insulin granules .
22039582	0	cholesterol	67,78	ABCA1	32,37	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	increases|dobj|START_ENTITY increases|nsubj|expression expression|nmod|END_ENTITY	Endothelial expression of human ABCA1 in mice increases plasma HDL cholesterol and reduces diet-induced atherosclerosis .
22129452	0	cholesterol	53,64	ABCA1	78,83	cholesterol	ABCA1	MESH:D002784	11303(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY transporters|nsubj|expression transporters|dobj|END_ENTITY	13-hydroxy_linoleic_acid increases expression of the cholesterol transporters ABCA1 , ABCG1 and SR-BI and stimulates apoA-I-dependent cholesterol efflux in RAW264 .7 macrophages .
22178192	0	cholesterol	54,65	ABCA1	76,81	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	export|compound|START_ENTITY impairs|dobj|export impairs|nmod|END_ENTITY	Site-specific oxidation of apolipoprotein_A-I impairs cholesterol export by ABCA1 , a key cardioprotective function of HDL .
22433669	0	cholesterol	42,53	ABCA1	16,21	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	efflux|compound|START_ENTITY mediates|dobj|efflux mediates|nsubj|expression expression|compound|END_ENTITY	Brain pericytes ABCA1 expression mediates cholesterol efflux but not cellular amyloid-b peptide accumulation .
22673513	0	cholesterol	30,41	ABCA1	62,67	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	efflux|compound|START_ENTITY controls|dobj|efflux controls|advcl|targeting targeting|dobj|END_ENTITY	MiR-26 controls LXR-dependent cholesterol efflux by targeting ABCA1 and ARL7 .
22981231	0	cholesterol	27,38	ABCA1	48,53	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Anticancer activity of the cholesterol exporter ABCA1 gene .
23042953	0	cholesterol	113,124	ABCA1	139,144	cholesterol	ABCA1	MESH:D002784	11303(Tax:10090)	Chemical	Gene	efflux|compound|START_ENTITY promoting|dobj|efflux promoting|nmod|transporter transporter|compound|END_ENTITY	Hydrophobic amino_acids in the hinge region of the 5A apolipoprotein mimetic peptide are essential for promoting cholesterol efflux by the ABCA1 transporter .
23136402	0	cholesterol	58,69	ABCA1	0,5	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	carriers|nmod|START_ENTITY carriers|nummod|END_ENTITY	ABCA1 mutation carriers with low high-density lipoprotein cholesterol are characterized by a larger atherosclerotic burden .
23305686	0	cholesterol	22,33	ABCA1	45,50	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	efflux|compound|START_ENTITY efflux|nmod|DNA DNA|compound|END_ENTITY	Homocysteine-mediated cholesterol efflux via ABCA1 and ACAT1 DNA methylation in THP-1 monocyte-derived foam cells .
23705956	8	cholesterol	1265,1276	ABCA1	1158,1163	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	transport|compound|START_ENTITY ABCA1|nmod|transport role|nmod|ABCA1 understand|dobj|role warranted|xcomp|understand regulation|acl:relcl|warranted regulation|nummod|END_ENTITY	CONCLUSION : In this review , we summarize the advances in the knowledge of ABCA1 posttranscriptional regulation , which is warranted to better understand the role of ABCA1 in reverse cholesterol transport , lipid metabolism , and atherosclerosis .
23814116	0	cholesterol	71,82	ABCA1	6,11	cholesterol	ABCA1	MESH:D002784	11303(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY impair|dobj|transport impair|nsubj|deletion deletion|compound|END_ENTITY	Liver ABCA1 deletion in LDLrKO mice does not impair macrophage reverse cholesterol transport or exacerbate atherogenesis .
23820125	0	cholesterol	81,92	ABCA1	122,127	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	transport|compound|START_ENTITY inhibition|nmod|transport inhibition|nmod|END_ENTITY	The novel anticancer agent JNJ-26854165 induces cell death through inhibition of cholesterol transport and degradation of ABCA1 .
24016265	0	cholesterol	95,106	ABCA1	62,67	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	efflux|compound|START_ENTITY promoting|dobj|efflux promoting|nsubj|protein protein|appos|END_ENTITY	The target of regulating the ATP-binding_cassette_A1 protein -LRB- ABCA1 -RRB- : promoting ABCA1-mediated cholesterol efflux in different cells .
24129191	0	cholesterol	147,158	ABCA1	141,146	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	efflux|compound|START_ENTITY efflux|nummod|END_ENTITY	Retention of a-helical structure by HDL mimetic peptide ATI-5261 upon extensive dilution represents an important determinant for stimulating ABCA1 cholesterol efflux with high efficiency .
24278306	2	cholesterol	322,333	ABCA1	347,352	cholesterol	NR1H3	MESH:D002784	10062	Chemical	Gene	transporters|compound|START_ENTITY transporters|dep|END_ENTITY	Activation of liver_X_receptor_a -LRB- LXRa -RRB- increases the expression of apolipoprotein_E -LRB- ApoE -RRB- as well as cholesterol transporters ABCA1 and ABCG1 , leading to augmented clearance of Ab .
24446142	1	cholesterol	224,235	ABCA1	289,294	cholesterol	ABCA1	MESH:D002784	313210(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY enhances|dobj|release enhances|nmod|ATP-binding_cassette_transporter_A1 ATP-binding_cassette_transporter_A1|appos|END_ENTITY	Activation of cdc42 reportedly enhances apoA-I-mediated cholesterol release through ATP-binding_cassette_transporter_A1 -LRB- ABCA1 -RRB- .
24462739	0	cholesterol	18,29	ABCA1	50,55	cholesterol	ABCA1	MESH:D002784	11303(Tax:10090)	Chemical	Gene	efflux|compound|START_ENTITY Regulation|nmod|efflux transporters|nsubj|Regulation transporters|dobj|END_ENTITY	Regulation of the cholesterol efflux transporters ABCA1 and ABCG1 in retina in hemochromatosis and by the endogenous siderophore 2,5-dihydroxybenzoic _ acid .
24463557	0	cholesterol	83,94	ABCA1	62,67	cholesterol	ABCA1	MESH:D002784	11303(Tax:10090)	Chemical	Gene	efflux|compound|START_ENTITY increases|dobj|efflux increases|nsubj|gene gene|compound|END_ENTITY	A novel gene regulator , pyrrole-imidazole_polyamide targeting ABCA1 gene increases cholesterol efflux from macrophages and plasma HDL concentration .
24500716	0	cholesterol	9,20	ABCA1	97,102	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|ubiquitination ubiquitination|nmod|END_ENTITY	Cellular cholesterol regulates ubiquitination and degradation of the cholesterol export proteins ABCA1 and ABCG1 .
24500716	7	cholesterol	925,936	ABCA1	972,977	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	loading|compound|START_ENTITY inhibits|nsubj|loading inhibits|dobj|ubiquitination ubiquitination|nmod|END_ENTITY	Furthermore , cell cholesterol loading inhibits ubiquitination of ABCA1 and ABCG1 .
24612239	0	cholesterol	26,37	ABCA1	51,56	cholesterol	ABCA1	MESH:D002784	481651(Tax:9615)	Chemical	Gene	Immunolocalization|nmod|START_ENTITY transporters|nsubj|Immunolocalization transporters|dobj|END_ENTITY	Immunolocalization of the cholesterol transporters ABCA1 and ABCG1 in canine reproductive tract tissues and spermatozoa .
24636347	0	cholesterol	9,20	ABCA1	47,52	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	efflux|nsubj|START_ENTITY efflux|xcomp|HDL HDL|nmod|transporter transporter|compound|END_ENTITY	Enhanced cholesterol efflux to HDL through the ABCA1 transporter in hypertriglyceridemia of type 2 diabetes .
24647144	0	cholesterol	48,59	ABCA1	42,47	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	efflux|compound|START_ENTITY efflux|compound|END_ENTITY	Humans with atherosclerosis have impaired ABCA1 cholesterol efflux and enhanced high-density lipoprotein oxidation by myeloperoxidase .
24735204	0	cholesterol	16,27	ABCA1	51,56	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	efflux|compound|START_ENTITY increases|dobj|efflux increases|advcl|upregulating upregulating|dobj|END_ENTITY	FGF21 increases cholesterol efflux by upregulating ABCA1 through the ERK1/2-PPARy-LXRa pathway in THP1 macrophage-derived foam cells .
24814386	0	cholesterol	90,101	ABCA1	127,132	cholesterol	ABCA1	MESH:D002784	313210(Tax:10116)	Chemical	Gene	using|dobj|START_ENTITY using|nmod|interaction interaction|nmod|END_ENTITY	Astrocyte s endogenous apoE generates HDL-like lipoproteins using previously synthesized cholesterol through interaction with ABCA1 .
24992457	3	cholesterol	613,624	ABCA1	572,577	cholesterol	ABCA1	MESH:D002784	11303(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY affect|dobj|transport affect|nsubj|HDL HDL|acl|associated associated|nmod|deletion deletion|nmod|END_ENTITY	RECENT FINDINGS : Recent studies show that low HDL associated with liver-specific deletion of ABCA1 does not affect macrophage reverse cholesterol transport or atherosclerosis susceptibility .
25579789	0	cholesterol	47,58	ABCA1	96,101	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	transport|compound|START_ENTITY role|nmod|transport plays|dobj|role plays|nmod|END_ENTITY	Position 834 in TM6 plays an important role in cholesterol and phosphatidylcholine transport by ABCA1 .
25733328	0	cholesterol	121,132	ABCA1	30,35	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	synthesis|nmod|START_ENTITY inhibiting|nmod|synthesis increases|advcl|inhibiting increases|dobj|expression expression|compound|END_ENTITY	Methyl_protodioscin increases ABCA1 expression and cholesterol efflux while inhibiting gene expressions for synthesis of cholesterol and triglycerides by suppressing SREBP transcription and microRNA 33a/b levels .
25877294	0	cholesterol	118,129	ABCA1	37,42	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	levels|compound|START_ENTITY polymorphism|dobj|levels polymorphism|nsubj|R219K R219K|appos|END_ENTITY	ATP-binding_cassette_transporter_A1 -LRB- ABCA1 -RRB- R219K -LRB- G1051A , rs2230806 -RRB- polymorphism and serum high-density lipoprotein cholesterol levels in a large Japanese population : cross-sectional data from the Daiko Study .
26103729	0	cholesterol	47,58	ABCA1	32,37	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	efflux|compound|START_ENTITY mediated|dobj|efflux mediated|nsubj|Progress Progress|nmod|pathways pathways|nmod|END_ENTITY	-LSB- Progress in signal pathways of ABCA1 mediated cholesterol efflux and anti-inflammatory -RSB- .
26198636	5	cholesterol	784,795	ABCA1	766,771	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	homeostasis|compound|START_ENTITY END_ENTITY|nmod|homeostasis	Several lines of clinical and experimental evidence suggest a second function of ABCA1 in cellular cholesterol homeostasis in addition to mediating cholesterol efflux .
26203076	0	cholesterol	60,71	ABCA1	0,5	cholesterol	ABCA1	MESH:D002784	11303(Tax:10090)	Chemical	Gene	deposition|nmod|START_ENTITY macrophage|dobj|deposition contributes|xcomp|macrophage contributes|nsubj|END_ENTITY	ABCA1 contributes to macrophage deposition of extracellular cholesterol .
26203076	0	cholesterol	60,71	ABCA1	0,5	cholesterol	ABCA1	MESH:D002784	11303(Tax:10090)	Chemical	Gene	deposition|nmod|START_ENTITY macrophage|dobj|deposition contributes|xcomp|macrophage contributes|nsubj|END_ENTITY	ABCA1 contributes to macrophage deposition of extracellular cholesterol .
26452260	0	cholesterol	79,90	ABCA1	119,124	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	efflux|compound|START_ENTITY efflux|nmod|up-regulation up-regulation|nmod|expression expression|compound|END_ENTITY	Liver X receptor reduces proliferation of human oral_cancer cells by promoting cholesterol efflux via up-regulation of ABCA1 expression .
26673204	0	cholesterol	98,109	ABCA1	134,139	cholesterol	ABCA1	MESH:D002784	11303(Tax:10090)	Chemical	Gene	capacity|compound|START_ENTITY capacity|nmod|pathway pathway|compound|END_ENTITY	Proteomic analysis of HDL from inbred mice strains implicates APOE associated with HDL in reduced cholesterol efflux capacity via the ABCA1 pathway .
26852751	0	cholesterol	47,58	ABCA1	73,78	cholesterol	ABCA1	MESH:D002784	100152112(Tax:9823)	Chemical	Gene	transporters|compound|START_ENTITY transporters|appos|END_ENTITY	Difference in expression patterns of placental cholesterol transporters , ABCA1 and SR-BI , in Meishan and Yorkshire pigs with different placental efficiency .
26879139	0	cholesterol	43,54	ABCA1	69,74	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	efflux|compound|START_ENTITY stimulate|dobj|efflux stimulate|nmod|transporter transporter|compound|END_ENTITY	Amphipathic polyproline peptides stimulate cholesterol efflux by the ABCA1 transporter .
27017521	0	cholesterol	55,66	ABCA1	120,125	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	efflux|compound|START_ENTITY promotes|dobj|efflux promotes|advcl|facilitating facilitating|nmod|END_ENTITY	Apolipoprotein_A-1_binding_protein promotes macrophage cholesterol efflux by facilitating apolipoprotein A-1 binding to ABCA1 and preventing ABCA1 degradation .
23931754	0	cholesterol	33,44	ABCA12	0,6	cholesterol	ABCA12	MESH:D002784	26154	Chemical	Gene	efflux|compound|START_ENTITY regulates|dobj|efflux regulates|nsubj|END_ENTITY	ABCA12 regulates ABCA1-dependent cholesterol efflux from macrophages and the development of atherosclerosis .
25817392	0	cholesterol	54,65	ABCA3	0,5	cholesterol	ABCA3	MESH:D002784	21	Chemical	Gene	protects|nmod|START_ENTITY protects|nsubj|END_ENTITY	ABCA3 protects alveolar epithelial cells against free cholesterol induced cell death .
16788211	0	cholesterol	42,53	ABCA7	0,5	cholesterol	ABCA7	MESH:D002784	27403(Tax:10090)	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|compound|END_ENTITY	ABCA7 expression is regulated by cellular cholesterol through the SREBP2 pathway and associated with phagocytosis .
12679197	5	cholesterol	1090,1101	ABCG1	1073,1078	cholesterol	ABCG5	MESH:D002784	64240	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|nmod|transport	The potential importance of ABCG1 in reverse cholesterol transport has not been definitively established .
15994327	0	cholesterol	25,36	ABCG1	0,5	cholesterol	ABCG1	MESH:D002784	9619	Chemical	Gene	redistributes|dobj|START_ENTITY redistributes|nsubj|END_ENTITY	ABCG1 redistributes cell cholesterol to domains removable by high density lipoprotein but not by lipid-depleted apolipoproteins .
16054048	0	cholesterol	24,35	ABCG1	0,5	cholesterol	ABCG1	MESH:D002784	9619	Chemical	Gene	transport|compound|START_ENTITY critical|nmod|transport END_ENTITY|dep|critical	ABCG1 : how critical for cholesterol transport ?
16054053	0	cholesterol	39,50	ABCG1	0,5	cholesterol	ABCG1	MESH:D002784	11307(Tax:10090)	Chemical	Gene	efflux|compound|START_ENTITY mediating|dobj|efflux role|acl|mediating has|dobj|role has|nsubj|END_ENTITY	ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation .
16352604	0	cholesterol	52,63	ABCG1	14,19	cholesterol	ABCG1	MESH:D002784	11307(Tax:10090)	Chemical	Gene	release|compound|START_ENTITY correlates|nmod|release correlates|nsubj|Expression Expression|nmod|END_ENTITY	Expression of ABCG1 , but not ABCA1 , correlates with cholesterol release by cerebellar astroglia .
16556852	0	cholesterol	79,90	ABCG1	30,35	cholesterol	ABCG1	MESH:D002784	9619	Chemical	Gene	efflux|compound|START_ENTITY enhances|dobj|efflux enhances|nsubj|redistribution redistribution|nmod|membrane membrane|nummod|plasma plasma|compound|END_ENTITY	LXR-induced redistribution of ABCG1 to plasma membrane in macrophages enhances cholesterol mass efflux to HDL .
16680029	5	cholesterol	988,999	ABCG1	974,979	cholesterol	ABCA1	MESH:D002784	19	Chemical	Gene	exports|dobj|START_ENTITY exports|nsubj|END_ENTITY	ABCG1 exports cholesterol to HDL and other phospholipid-containing acceptors .
17121837	0	cholesterol	50,61	ABCG1	8,13	cholesterol	ABCG1	MESH:D002784	9619	Chemical	Gene	efflux|compound|START_ENTITY Role|nmod|efflux Role|nmod|END_ENTITY	Role of ABCG1 and ABCA1 in regulation of neuronal cholesterol efflux to apolipoprotein_E discs and suppression of amyloid-beta peptide generation .
17761632	0	cholesterol	28,39	ABCG1	59,64	cholesterol	ABCG1	MESH:D002784	9619	Chemical	Gene	efflux|compound|START_ENTITY Sphingomyelin-dependence|nmod|efflux mediated|nsubj|Sphingomyelin-dependence mediated|nmod|END_ENTITY	Sphingomyelin-dependence of cholesterol efflux mediated by ABCG1 .
18314463	0	cholesterol	27,38	ABCG1	0,5	cholesterol	ABCG1	MESH:D002784	11307(Tax:10090)	Chemical	Gene	biosynthetic|nsubj|START_ENTITY influences|xcomp|biosynthetic influences|nsubj|END_ENTITY	ABCG1 influences the brain cholesterol biosynthetic pathway but does not affect amyloid precursor protein or apolipoprotein_E metabolism in vivo .
19481530	0	cholesterol	21,32	ABCG1	126,131	cholesterol	ABCG1	MESH:D002784	9619	Chemical	Gene	efflux|compound|START_ENTITY required|nmod|efflux required|advcl|triggering triggering|nmod|locus locus|nummod|END_ENTITY	GPS2 is required for cholesterol efflux by triggering histone demethylation , LXR recruitment , and coregulator assembly at the ABCG1 locus .
21289254	0	cholesterol	95,106	ABCG1	59,64	cholesterol	ABCG1	MESH:D002784	9619	Chemical	Gene	efflux|compound|START_ENTITY efflux|nmod|SR-BI SR-BI|nummod|END_ENTITY	Effect of bariatric surgery-induced weight_loss on SR-BI - , ABCG1 - , and ABCA1-mediated cellular cholesterol efflux in obese women .
22198513	0	cholesterol	43,54	ABCG1	68,73	cholesterol	ABCG1	MESH:D002784	100534490	Chemical	Gene	expression|nmod|START_ENTITY transporters|nsubj|expression transporters|dobj|END_ENTITY	Cloning and functional expression of novel cholesterol transporters ABCG1 and ABCG4 in gonadotropin-releasing_hormone neurons of the tilapia .
22984960	0	cholesterol	56,67	ABCG1	22,27	cholesterol	ABCG1	MESH:D002784	100759619	Chemical	Gene	efflux|compound|START_ENTITY ABCG1-mediated|dobj|efflux ABCG1-mediated|nsubj|associates associates|nmod|END_ENTITY	SR-BI associates with ABCG1 and inhibits ABCG1-mediated cholesterol efflux from cells to high-density lipoprotein 3 .
23172659	0	cholesterol	48,59	ABCG1	25,30	cholesterol	ABCG1	MESH:D002784	9619	Chemical	Gene	stimulated|nmod|START_ENTITY stimulated|nsubjpass|activity activity|nmod|END_ENTITY	ATPase activity of human ABCG1 is stimulated by cholesterol and sphingomyelin .
24367046	0	cholesterol	49,60	ABCG1	101,106	cholesterol	ABCG1	MESH:D002784	11307(Tax:10090)	Chemical	Gene	efflux|compound|START_ENTITY induced|nmod|efflux induced|advcl|downregulating downregulating|dobj|END_ENTITY	IL-22 is induced by S100/calgranulin and impairs cholesterol efflux in macrophages by downregulating ABCG1 .
25724068	0	cholesterol	40,51	ABCG1	28,33	cholesterol	ABCG1	MESH:D002784	11307(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY links|dobj|homeostasis links|nsubj|END_ENTITY	The cholesterol transporter ABCG1 links cholesterol homeostasis and tumour immunity .
20130569	0	cholesterol	66,77	ABCG2	0,5	cholesterol	ABCG2	MESH:D002784	9429	Chemical	Gene	response|compound|START_ENTITY associated|nmod|response associated|nsubjpass|polymorphism polymorphism|compound|END_ENTITY	ABCG2 polymorphism is associated with the low-density lipoprotein cholesterol response to rosuvastatin .
1487138	0	cholesterol	76,87	ABO	46,49	cholesterol	ABO	MESH:D002784	28	Chemical	Gene	level|compound|START_ENTITY level|compound|END_ENTITY	Longitudinal study of the association between ABO phenotype and total serum cholesterol level in a Japanese cohort .
26419984	0	cholesterol	7,18	ABO_blood_group	42,57	cholesterol	ABO blood group	MESH:D002784	28	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|dobj|effect effect|nmod|END_ENTITY	-LSB- Total cholesterol mediates the effect of ABO_blood_group on coronary_heart_disease -RSB- .
20602615	0	cholesterol	132,143	ACACB	94,99	cholesterol	ACACB	MESH:D002784	32	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Physiogenomic analysis of statin-treated patients : domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol ?
15658270	0	cholesterol	18,29	ACAT	47,51	cholesterol	ACAT	MESH:D002784	1066	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Acyl-coenzyme_A : cholesterol acyltransferase -LRB- ACAT -RRB- -RSB- .
7869831	0	cholesterol	46,57	ACAT	27,31	cholesterol	ACAT	MESH:D002784	100009537(Tax:9986)	Chemical	Gene	accumulation|compound|START_ENTITY END_ENTITY|nmod|accumulation	Effects of HL-004 , a novel ACAT inhibitor , on cholesterol accumulation and removal in cultured smooth muscle cells from stroke-prone spontaneously hypertensive rats -LRB- SHRSP -RRB- .
20101629	0	cholesterol	9,20	ACAT1	39,44	cholesterol	ACAT1	MESH:D002784	38	Chemical	Gene	esterification|compound|START_ENTITY esterification|nmod|END_ENTITY	Neuronal cholesterol esterification by ACAT1 in Alzheimer 's _ disease .
22669916	0	cholesterol	51,62	ACAT2	0,5	cholesterol	ACAT2	MESH:D002784	110460(Tax:10090)	Chemical	Gene	absorption|compound|START_ENTITY required|nmod|absorption required|nsubjpass|END_ENTITY	ACAT2 and ABCG5/G8 are both required for efficient cholesterol absorption in mice : evidence from thoracic lymph duct cannulation .
3115319	0	cholesterol	10,21	AII_and_B	45,54	cholesterol	AII and B	MESH:D002784	114548	Chemical	Gene	START_ENTITY|appos|levels levels|compound|END_ENTITY	Serum HDL cholesterol and apolipoprotein AI , AII_and_B levels in Singapore newborns .
20800056	0	cholesterol	67,78	APOA-I	13,19	cholesterol	APOA-I	MESH:D002784	335	Chemical	Gene	levels|nmod|START_ENTITY Mutations|nmod|levels Mutations|nmod|END_ENTITY	Mutations in APOA-I and ABCA1 in Norwegians with low levels of HDL cholesterol .
10636159	0	cholesterol	6,17	APOE	19,23	cholesterol	APOE	MESH:D002784	348	Chemical	Gene	START_ENTITY|appos|genotype genotype|amod|END_ENTITY	Serum cholesterol , APOE genotype , and the risk of Alzheimer 's _ disease : a population-based study of African Americans .
15229191	0	cholesterol	31,42	APOE	23,27	cholesterol	APOE	MESH:D002784	11816(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY effects|nmod|metabolism effects|nmod|END_ENTITY	Independent effects of APOE on cholesterol metabolism and brain Abeta levels in an Alzheimer_disease mouse model .
16528057	0	cholesterol	48,59	APOE	13,17	cholesterol	APOE	MESH:D002784	348	Chemical	Gene	LDL|dobj|START_ENTITY polymorphisms|xcomp|LDL polymorphisms|nsubj|Relations Relations|nmod|promoter promoter|amod|END_ENTITY	Relations of APOE promoter polymorphisms to LDL cholesterol and markers of subclinical atherosclerosis in young adults .
19013289	0	cholesterol	72,83	APOE	0,4	cholesterol	APOE	MESH:D002784	348	Chemical	Gene	subspecies|compound|START_ENTITY responses|nmod|subspecies affects|dobj|responses affects|nsubj|genotype genotype|compound|END_ENTITY	APOE genotype affects black-white responses of high-density lipoprotein cholesterol subspecies to aerobic exercise training .
23067351	0	cholesterol	26,37	APOE	131,135	cholesterol	APOE	MESH:D002784	348	Chemical	Gene	GWAS|nmod|START_ENTITY reveals|nsubj|GWAS reveals|dobj|variant variant|nmod|END_ENTITY	High density GWAS for LDL cholesterol in African Americans using electronic medical records reveals a strong protective variant in APOE .
25073452	0	cholesterol	54,65	APOE	21,25	cholesterol	APOE	MESH:D002784	348	Chemical	Gene	genotypes|compound|START_ENTITY genotypes|amod|END_ENTITY	Associations between APOE and low-density lipoprotein cholesterol genotypes and cognitive and physical capability : the HALCyon programme .
26673204	0	cholesterol	98,109	APOE	62,66	cholesterol	APOE	MESH:D002784	11816(Tax:10090)	Chemical	Gene	capacity|compound|START_ENTITY associated|nmod|capacity END_ENTITY|acl|associated	Proteomic analysis of HDL from inbred mice strains implicates APOE associated with HDL in reduced cholesterol efflux capacity via the ABCA1 pathway .
14559902	0	cholesterol	109,120	ATP-binding_cassette_transporter_A1	60,95	cholesterol	ATP-binding cassette transporter A1	MESH:D002784	11303(Tax:10090)	Chemical	Gene	efflux|compound|START_ENTITY efflux|amod|END_ENTITY	Phospholipid transfer protein interacts with and stabilizes ATP-binding_cassette_transporter_A1 and enhances cholesterol efflux from cells .
19602833	0	cholesterol	205,216	ATP-binding_cassette_transporter_G5	90,125	cholesterol	ATP-binding cassette transporter G5	MESH:D002784	114628(Tax:10116)	Chemical	Gene	mRNA|nmod|START_ENTITY mRNA|amod|END_ENTITY	Dietary soy protein isolate and its undigested high_molecular_fraction upregulate hepatic ATP-binding_cassette_transporter_G5 and ATP-binding_cassette_transporter_G8 mRNA and increase biliary secretion of cholesterol in rats .
18220685	0	cholesterol	114,125	ATP-binding_cassette_transporter_subfamily_A_member_1	4,57	cholesterol	ATP-binding cassette transporter subfamily A member 1	MESH:D002784	11303(Tax:10090)	Chemical	Gene	association|nmod|START_ENTITY END_ENTITY|dep|association	The ATP-binding_cassette_transporter_subfamily_A_member_1 -LRB- ABC-A1 -RRB- and type 2 diabetes : an association beyond HDL cholesterol .
18039927	0	cholesterol	52,63	ATP-binding_cassette_transporters_G1	0,36	cholesterol	ATP-binding cassette transporters G1	MESH:D002784	11307(Tax:10090)	Chemical	Gene	efflux|compound|START_ENTITY mediate|dobj|efflux mediate|nsubj|END_ENTITY	ATP-binding_cassette_transporters_G1 and G4 mediate cholesterol and desmosterol efflux to HDL and regulate sterol accumulation in the brain .
21740892	0	cholesterol	26,37	ATP_binding_cassette_transporter_A1	90,125	cholesterol	ATP binding cassette transporter A1	MESH:D002784	19	Chemical	Gene	efflux|compound|START_ENTITY increasing|dobj|efflux increasing|nmod|END_ENTITY	Possibility of increasing cholesterol efflux by adiponectin and its receptors through the ATP_binding_cassette_transporter_A1 in HEK293T cells .
17029589	0	cholesterol	78,89	ATPase	30,36	cholesterol	ATPase	MESH:D002784	1769	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|activity activity|amod|END_ENTITY	Modulation of drug-stimulated ATPase activity of human MDR1/P-glycoprotein by cholesterol .
8161559	0	cholesterol	18,29	ATPase	40,46	cholesterol	ATPase	MESH:D002784	1769	Chemical	Gene	Binding|nmod|START_ENTITY Binding|dep|END_ENTITY	Binding sites for cholesterol on Ca -LRB- 2 + -RRB- - ATPase studied by using a cholesterol-containing phospholipid .
18552351	0	cholesterol	24,35	Abca1	59,64	cholesterol	Abca1	MESH:D002784	11303(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Increased cellular free cholesterol in macrophage-specific Abca1 knock-out mice enhances pro-inflammatory response of macrophages .
19339012	0	cholesterol	128,139	Abcg1	8,13	cholesterol	Abcg1	MESH:D002784	11307(Tax:10090)	Chemical	Gene	diet|compound|START_ENTITY fed|dobj|diet fed|nsubj|Lack Lack|nmod|results results|amod|END_ENTITY	Lack of Abcg1 results in decreased plasma HDL cholesterol levels and increased biliary cholesterol secretion in mice fed a high cholesterol diet .
19339012	0	cholesterol	46,57	Abcg1	8,13	cholesterol	Abcg1	MESH:D002784	11307(Tax:10090)	Chemical	Gene	levels|compound|START_ENTITY results|nmod|levels results|amod|END_ENTITY	Lack of Abcg1 results in decreased plasma HDL cholesterol levels and increased biliary cholesterol secretion in mice fed a high cholesterol diet .
17472705	0	cholesterol	16,27	Abeta	50,55	cholesterol	Abeta	MESH:D002784	11820(Tax:10090)	Chemical	Gene	affect|nsubj|START_ENTITY affect|dobj|END_ENTITY	Elevated plasma cholesterol does not affect brain Abeta in mice lacking the low-density_lipoprotein_receptor .
16551729	0	cholesterol	84,95	Adiponectin	0,11	cholesterol	Adiponectin	MESH:D002784	9370	Chemical	Gene	related|nmod|START_ENTITY related|nsubjpass|END_ENTITY	Adiponectin in umbilical cord blood is inversely related to low-density lipoprotein cholesterol but not ethnicity .
17521614	0	cholesterol	32,43	Adiponectin	0,11	cholesterol	Adiponectin	MESH:D002784	9370	Chemical	Gene	transport|compound|START_ENTITY accelerates|dobj|transport accelerates|nsubj|END_ENTITY	Adiponectin accelerates reverse cholesterol transport by increasing high density lipoprotein assembly in the liver .
18703020	0	cholesterol	51,62	Adiponectin	0,11	cholesterol	Adiponectin	MESH:D002784	9370	Chemical	Gene	efflux|compound|START_ENTITY increasing|dobj|efflux prevents|advcl|increasing prevents|nsubj|END_ENTITY	Adiponectin prevents atherosclerosis by increasing cholesterol efflux from macrophages .
23466101	0	cholesterol	34,45	Adiponectin	0,11	cholesterol	Adiponectin	MESH:D002784	9370	Chemical	Gene	efflux|compound|START_ENTITY macrophages|dobj|efflux macrophages|nsubj|increases increases|compound|END_ENTITY	Adiponectin increases macrophages cholesterol efflux and suppresses foam cell formation in patients with type 2 diabetes_mellitus .
17110602	0	cholesterol	48,59	Angiopoietin-like_protein3	0,26	cholesterol	Angiopoietin-like protein3	MESH:D002784	30924(Tax:10090)	Chemical	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Angiopoietin-like_protein3 regulates plasma HDL cholesterol through suppression of endothelial lipase .
17196163	0	cholesterol	29,40	Angiotensin_II	0,14	cholesterol	Angiotensin II	MESH:D002784	183	Chemical	Gene	content|compound|START_ENTITY increases|dobj|content increases|nsubj|END_ENTITY	Angiotensin_II increases the cholesterol content of foam cells via down-regulating the expression of ATP-binding_cassette_transporter_A1 .
10364075	0	cholesterol	73,84	ApoA-I	16,22	cholesterol	ApoA-I	MESH:D002784	11806(Tax:10090)	Chemical	Gene	levels|compound|START_ENTITY associated|nmod|levels associated|nsubjpass|mutant mutant|appos|nichinan nichinan|amod|END_ENTITY	A novel mutant , ApoA-I nichinan -LRB- Glu235 -- > 0 -RRB- , is associated with low HDL cholesterol levels and decreased cholesterol efflux from cells .
11882653	0	cholesterol	108,119	ApoA-I	47,53	cholesterol	ApoA-I	MESH:D002784	335	Chemical	Gene	efflux|compound|START_ENTITY I|dep|efflux END_ENTITY|nmod|I	The effects of mutations in helices 4 and 6 of ApoA-I on scavenger receptor class B type I -LRB- SR-BI -RRB- - mediated cholesterol efflux suggest that formation of a productive complex between reconstituted high density lipoprotein and SR-BI is required for efficient lipid transport .
17693625	0	cholesterol	63,74	ApoA-I	0,6	cholesterol	ApoA-I	MESH:D002784	11806(Tax:10090)	Chemical	Gene	efflux|compound|START_ENTITY promote|dobj|efflux reduced|advcl|promote reduced|nsubj|END_ENTITY	ApoA-I cleaved by transthyretin has reduced ability to promote cholesterol efflux and increased amyloidogenicity .
19661486	0	cholesterol	19,30	ApoA-I	60,66	cholesterol	ApoA-I	MESH:D002784	11806(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY transport|nmod|mice mice|acl|expressing expressing|dobj|Milano Milano|compound|END_ENTITY	Macrophage reverse cholesterol transport in mice expressing ApoA-I Milano .
21697542	0	cholesterol	45,56	ApoA-I	67,73	cholesterol	ApoA-I	MESH:D002784	335	Chemical	Gene	efflux|compound|START_ENTITY mediate|dobj|efflux mediate|nmod|END_ENTITY	ABCA1 increases extracellular ATP to mediate cholesterol efflux to ApoA-I .
22171091	0	cholesterol	61,72	ApoA-I	20,26	cholesterol	ApoA-I	MESH:D002784	11806(Tax:10090)	Chemical	Gene	esterification|compound|START_ENTITY restoring|dobj|esterification P2a|acl|restoring P2a|amod|Apolipoprotein_A-I Apolipoprotein_A-I|dep|END_ENTITY	Apolipoprotein_A-I -LRB- ApoA-I -RRB- mimetic peptide P2a by restoring cholesterol esterification unmasks ApoA-I anti-inflammatory endogenous activity in vivo .
22171091	0	cholesterol	61,72	ApoA-I	96,102	cholesterol	ApoA-I	MESH:D002784	11806(Tax:10090)	Chemical	Gene	esterification|compound|START_ENTITY restoring|dobj|esterification P2a|acl|restoring unmasks|nsubj|P2a unmasks|dobj|activity activity|amod|END_ENTITY	Apolipoprotein_A-I -LRB- ApoA-I -RRB- mimetic peptide P2a by restoring cholesterol esterification unmasks ApoA-I anti-inflammatory endogenous activity in vivo .
23041415	0	cholesterol	134,145	ApoA-I	32,38	cholesterol	ApoA-I	MESH:D002784	335	Chemical	Gene	load|nmod|START_ENTITY suggests|nmod|load suggests|nsubj|structure structure|nmod|END_ENTITY	Crystal structure of / \ -LRB- 185-243 -RRB- ApoA-I suggests a mechanistic framework for the protein adaptation to the changing lipid load in good cholesterol : from flatland to sphereland via double belt , belt buckle , double hairpin and trefoil/tetrafoil .
10634808	0	cholesterol	95,106	ApoE	35,39	cholesterol	ApoE	MESH:D002784	11816(Tax:10090)	Chemical	Gene	levels|compound|START_ENTITY Effect|nmod|levels Effect|nmod|END_ENTITY	Effect of macrophage-derived mouse ApoE , human ApoE3-Leiden , and human ApoE2 -LRB- Arg158 -- > Cys -RRB- on cholesterol levels and atherosclerosis in ApoE-deficient mice .
11742881	0	cholesterol	20,31	ApoE	101,105	cholesterol	ApoE	MESH:D002784	11816(Tax:10090)	Chemical	Gene	inhibitor|compound|START_ENTITY Ezetimibe|appos|inhibitor inhibits|nsubj|Ezetimibe inhibits|dobj|development development|nmod|atherosclerosis atherosclerosis|nmod|mice mice|compound|END_ENTITY	Ezetimibe , a potent cholesterol absorption inhibitor , inhibits the development of atherosclerosis in ApoE knockout mice .
14697997	0	cholesterol	27,38	ApoE	65,69	cholesterol	ApoE	MESH:D002784	11816(Tax:10090)	Chemical	Gene	content|compound|START_ENTITY sirolimus|nmod|content Effect|nmod|sirolimus arch|nsubj|Effect arch|nmod|mice mice|compound|END_ENTITY	Effect of sirolimus on the cholesterol content of aortic arch in ApoE knockout mice .
16185081	0	cholesterol	15,26	ApoE	72,76	cholesterol	ApoE	MESH:D002784	348	Chemical	Gene	efflux|compound|START_ENTITY mediates|dobj|efflux mediates|nmod|END_ENTITY	SR-BI mediates cholesterol efflux via its interactions with lipid-bound ApoE .
16873727	0	cholesterol	126,137	ApoE	37,41	cholesterol	ApoE	MESH:D002784	11816(Tax:10090)	Chemical	Gene	lowering|dobj|START_ENTITY effects|acl|lowering evidence|nmod|effects reduces|parataxis|evidence reduces|iobj|atherogenesis atherogenesis|nmod|END_ENTITY	Fenofibrate reduces atherogenesis in ApoE * 3Leiden mice : evidence for multiple antiatherogenic effects besides lowering plasma cholesterol .
17504523	0	cholesterol	100,111	ApoE	34,38	cholesterol	ApoE	MESH:D002784	348	Chemical	Gene	release|compound|START_ENTITY inhibits|dobj|release inhibits|nsubj|action action|nmod|apolipoprotein_E apolipoprotein_E|appos|END_ENTITY	Novel action of apolipoprotein_E -LRB- ApoE -RRB- : ApoE isoform specifically inhibits lipid-particle-mediated cholesterol release from neurons .
17504523	0	cholesterol	100,111	ApoE	41,45	cholesterol	ApoE	MESH:D002784	348	Chemical	Gene	release|compound|START_ENTITY inhibits|dobj|release inhibits|nsubj|action action|nmod|apolipoprotein_E apolipoprotein_E|dep|isoform isoform|compound|END_ENTITY	Novel action of apolipoprotein_E -LRB- ApoE -RRB- : ApoE isoform specifically inhibits lipid-particle-mediated cholesterol release from neurons .
19715613	0	cholesterol	49,60	ApoE	90,94	cholesterol	ApoE	MESH:D002784	348	Chemical	Gene	proteins|compound|START_ENTITY proteins|nmod|END_ENTITY	Psychotropic drugs up-regulate the expression of cholesterol transport proteins including ApoE in cultured human CNS - and liver cells .
21130458	0	cholesterol	121,132	ApoE	79,83	cholesterol	ApoE	MESH:D002784	11816(Tax:10090)	Chemical	Gene	levels|compound|START_ENTITY independent|nmod|levels independent|nsubj|development development|nmod|mice mice|compound|END_ENTITY	Atorvastatin inhibits plaque development and adventitial neovascularization in ApoE deficient mice independent of plasma cholesterol levels .
21488185	0	cholesterol	56,67	ApoE	0,4	cholesterol	ApoE	MESH:D002784	348	Chemical	Gene	level|compound|START_ENTITY determine|dobj|level determine|nsubj|polymorphism polymorphism|compound|END_ENTITY	ApoE polymorphism may determine low-density lipoprotein cholesterol level in association with obesity and metabolic_syndrome in postmenopausal Korean women .
22383685	0	cholesterol	83,94	ApoE	0,4	cholesterol	ApoE	MESH:D002784	11816(Tax:10090)	Chemical	Gene	efflux|compound|START_ENTITY promotes|nmod|efflux promotes|nsubj|END_ENTITY	ApoE promotes hepatic selective uptake but not RCT due to increased ABCA1-mediated cholesterol efflux to plasma .
24324578	0	cholesterol	85,96	ApoE	119,123	cholesterol	ApoE	MESH:D002784	11816(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|circulation circulation|nmod|mice mice|compound|END_ENTITY	The thyroid receptor modulator KB3495 reduces atherosclerosis independently of total cholesterol in the circulation in ApoE deficient mice .
24803317	7	cholesterol	1429,1440	Apoe	1463,1467	cholesterol	IL-6	MESH:D002784	3569	Chemical	Gene	levels|compound|START_ENTITY decreased|dobj|levels decreased|nmod|mice mice|compound|END_ENTITY	Although DHI reduced HMG-CoA reductase messenger RNA expression in both female Apoe / and Ldlr / mice , it decreased low-density lipoprotein cholesterol levels only in female Apoe / mice .
10355509	0	cholesterol	36,47	Apolipoprotein_A-I	0,18	cholesterol	Apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	crystallization|compound|START_ENTITY inhibits|dobj|crystallization inhibits|nsubj|END_ENTITY	Apolipoprotein_A-I in bile inhibits cholesterol crystallization and modifies transcellular lipid transfer through cultured human gall-bladder epithelial cells .
11485554	0	cholesterol	61,72	Apolipoprotein_A-I	0,18	cholesterol	Apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	transport|nmod|START_ENTITY stimulates|dobj|transport stimulates|nsubj|END_ENTITY	Apolipoprotein_A-I stimulates the transport of intracellular cholesterol to cell-surface cholesterol-rich domains -LRB- caveolae -RRB- .
11773045	0	cholesterol	44,55	Apolipoprotein_A-I	0,18	cholesterol	Apolipoprotein A-I	MESH:D002784	25081(Tax:10116)	Chemical	Gene	translocation|nmod|START_ENTITY induces|dobj|translocation induces|nsubj|END_ENTITY	Apolipoprotein_A-I induces translocation of cholesterol , phospholipid , and caveolin-1 to cytosol in rat astrocytes .
16606364	0	cholesterol	54,65	Apolipoprotein_A-I	0,18	cholesterol	Apolipoprotein A-I	MESH:D002784	25081(Tax:10116)	Chemical	Gene	association|nmod|START_ENTITY increases|dobj|association increases|nsubj|END_ENTITY	Apolipoprotein_A-I increases association of cytosolic cholesterol and caveolin-1 with microtubule cytoskeletons in rat astrocytes .
22171091	0	cholesterol	61,72	Apolipoprotein_A-I	0,18	cholesterol	Apolipoprotein A-I	MESH:D002784	11806(Tax:10090)	Chemical	Gene	esterification|compound|START_ENTITY restoring|dobj|esterification P2a|acl|restoring P2a|amod|END_ENTITY	Apolipoprotein_A-I -LRB- ApoA-I -RRB- mimetic peptide P2a by restoring cholesterol esterification unmasks ApoA-I anti-inflammatory endogenous activity in vivo .
24814947	0	cholesterol	71,82	Apolipoprotein_A-I	0,18	cholesterol	Apolipoprotein A-I	MESH:D002784	25081(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY induces|nmod|release induces|nsubj|END_ENTITY	Apolipoprotein_A-I induces tubulin phosphorylation in association with cholesterol release in fetal rat astrocytes .
25558595	0	cholesterol	108,119	Apolipoprotein_A-I	1,19	cholesterol	Apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	measurements|compound|START_ENTITY gain|advcl|measurements do|ccomp|gain dyslipidemia|dep|do diagnostics|nmod|dyslipidemia END_ENTITY|nmod|diagnostics	-LSB- Apolipoprotein_A-I and B in laboratory diagnostics of dyslipidemia -- what benefits do we gain compared with cholesterol measurements ? -RSB- .
8798607	0	cholesterol	129,140	Apolipoprotein_A-I	0,18	cholesterol	Apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	efflux|compound|START_ENTITY particles|nmod|efflux particles|nsubj|modification modification|amod|END_ENTITY	Apolipoprotein_A-I structural modification and the functionality of reconstituted high density lipoprotein particles in cellular cholesterol efflux .
9869653	0	cholesterol	28,39	Apolipoprotein_A-I	0,18	cholesterol	Apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	release|compound|START_ENTITY promotes|dobj|release promotes|nsubj|END_ENTITY	Apolipoprotein_A-I promotes cholesterol release and apolipoprotein_E recruitment from THP-1 macrophage-like foam cells .
22745238	0	cholesterol	70,81	Apolipoprotein_B-100	0,20	cholesterol	Apolipoprotein B-100	MESH:D002784	338	Chemical	Gene	efflux|compound|START_ENTITY determinants|nmod|efflux kinetics|nmod|determinants kinetics|nsubj|END_ENTITY	Apolipoprotein_B-100 and apoA-II kinetics as determinants of cellular cholesterol efflux .
10094101	0	cholesterol	77,88	Apolipoprotein_E	0,16	cholesterol	Apolipoprotein E	MESH:D002784	348	Chemical	Gene	changes|nmod|START_ENTITY affects|dobj|changes affects|nsubj|END_ENTITY	Apolipoprotein_E affects serial changes in total and low-density lipoprotein cholesterol in adolescent girls : Project HeartBeat !
10725355	0	cholesterol	35,46	Apolipoprotein_E	0,16	cholesterol	Apolipoprotein E	MESH:D002784	11816(Tax:10090)	Chemical	Gene	absorption|compound|START_ENTITY regulates|dobj|absorption regulates|nsubj|END_ENTITY	Apolipoprotein_E regulates dietary cholesterol absorption and biliary cholesterol excretion : studies in C57BL/6 apolipoprotein_E knockout mice .
10870678	0	cholesterol	43,54	Apolipoprotein_E	0,16	cholesterol	Apolipoprotein E	MESH:D002784	348	Chemical	Gene	efflux|nmod|START_ENTITY accelerates|dobj|efflux accelerates|nsubj|END_ENTITY	Apolipoprotein_E accelerates the efflux of cholesterol from macrophages : mechanism of xanthoma formation in apolipoprotein_E_deficiency .
11229881	0	cholesterol	20,31	Apolipoprotein_E	0,16	cholesterol	Apolipoprotein E	MESH:D002784	348	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|dep|protein	Apolipoprotein_E : a cholesterol transport protein with lipid transport-independent cell signaling properties .
11726725	0	cholesterol	37,48	Apolipoprotein_E	0,16	cholesterol	Apolipoprotein E	MESH:D002784	348	Chemical	Gene	absorption|compound|START_ENTITY regulates|dobj|absorption regulates|nsubj|phenotype phenotype|amod|END_ENTITY	Apolipoprotein_E phenotype regulates cholesterol absorption in healthy 13-month-old children -- The STRIP Study .
15591220	0	cholesterol	93,104	Apolipoprotein_E	0,16	cholesterol	Apolipoprotein E	MESH:D002784	11816(Tax:10090)	Chemical	Gene	levels|compound|START_ENTITY lowering|dobj|levels regression|acl|lowering promotes|dobj|regression promotes|nsubj|END_ENTITY	Apolipoprotein_E promotes the regression of atherosclerosis independently of lowering plasma cholesterol levels .
15639314	0	cholesterol	18,29	Apolipoprotein_E	0,16	cholesterol	Apolipoprotein E	MESH:D002784	348	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|appos|transport	Apolipoprotein_E , cholesterol transport and synthesis in sporadic Alzheimer 's _ disease .
15939819	0	cholesterol	60,71	Apolipoprotein_E	0,16	cholesterol	Apolipoprotein E	MESH:D002784	100009337(Tax:9986)	Chemical	Gene	lowers|dobj|START_ENTITY lowers|nsubj|Peptide Peptide|compound|END_ENTITY	Apolipoprotein_E mimetic Peptide dramatically lowers plasma cholesterol and restores endothelial function in watanabe heritable hyperlipidemic rabbits .
16760224	0	cholesterol	63,74	Apolipoprotein_E	0,16	cholesterol	Apolipoprotein E	MESH:D002784	348	Chemical	Gene	levels|compound|START_ENTITY predict|dobj|levels predict|nsubj|polymorphisms polymorphisms|amod|END_ENTITY	Apolipoprotein_E polymorphisms predict low density lipoprotein cholesterol levels and carotid artery wall thickness but not incident coronary_heart_disease in 12,491 ARIC study participants .
19638223	0	cholesterol	165,176	Apolipoprotein_E	122,138	cholesterol	Apolipoprotein E	MESH:D002784	11816(Tax:10090)	Chemical	Gene	fed|dobj|START_ENTITY mice|acl|fed mice|amod|END_ENTITY	Protonated nanostructured aluminosilicate -LRB- NSAS -RRB- reduces plasma cholesterol concentrations and atherosclerotic_lesions in Apolipoprotein_E deficient mice fed a high cholesterol and high fat diet .
19638223	0	cholesterol	64,75	Apolipoprotein_E	122,138	cholesterol	Apolipoprotein E	MESH:D002784	11816(Tax:10090)	Chemical	Gene	concentrations|compound|START_ENTITY reduces|dobj|concentrations reduces|nmod|mice mice|amod|END_ENTITY	Protonated nanostructured aluminosilicate -LRB- NSAS -RRB- reduces plasma cholesterol concentrations and atherosclerotic_lesions in Apolipoprotein_E deficient mice fed a high cholesterol and high fat diet .
1988781	0	cholesterol	51,62	Apolipoprotein_E	0,16	cholesterol	Apolipoprotein E	MESH:D002784	348	Chemical	Gene	response|compound|START_ENTITY influences|dobj|response influences|nsubj|polymorphism polymorphism|compound|END_ENTITY	Apolipoprotein_E polymorphism influences the serum cholesterol response to dietary intervention .
21597008	0	cholesterol	67,78	Apolipoprotein_E	0,16	cholesterol	Apolipoprotein E	MESH:D002784	11816(Tax:10090)	Chemical	Gene	clearance|compound|START_ENTITY enhanced|dobj|clearance enhanced|nsubj|mediates mediates|amod|END_ENTITY	Apolipoprotein_E mediates enhanced plasma high-density lipoprotein cholesterol clearance by low-dose streptococcal serum opacity factor via hepatic low-density lipoprotein receptors in vivo .
22130662	0	cholesterol	89,100	Apolipoprotein_E	0,16	cholesterol	Apolipoprotein E	MESH:D002784	348	Chemical	Gene	levels|compound|START_ENTITY modulating|dobj|levels promotes|advcl|modulating promotes|nsubj|END_ENTITY	Apolipoprotein_E promotes b-amyloid trafficking and degradation by modulating microglial cholesterol levels .
23934233	0	cholesterol	107,118	Apolipoprotein_E	0,16	cholesterol	Apolipoprotein E	MESH:D002784	348	Chemical	Gene	homeostasis|compound|START_ENTITY deregulating|dobj|homeostasis influences|advcl|deregulating influences|nsubj|polymorphism polymorphism|amod|END_ENTITY	Apolipoprotein_E gene polymorphism influences aggressive behavior in prostate_cancer cells by deregulating cholesterol homeostasis .
25140128	0	cholesterol	90,101	Apolipoprotein_E	64,80	cholesterol	Apolipoprotein E	MESH:D002784	25728(Tax:10116)	Chemical	Gene	trafficking|compound|START_ENTITY trafficking|amod|END_ENTITY	Haptoglobin increases with age in rat hippocampus and modulates Apolipoprotein_E mediated cholesterol trafficking in neuroblastoma cell lines .
26817942	0	cholesterol	48,59	Apolipoprotein_E	0,16	cholesterol	Apolipoprotein E	MESH:D002784	348	Chemical	Gene	epsilon|dobj|START_ENTITY epsilon|nsubj|END_ENTITY	Apolipoprotein_E epsilon 2 allele and low serum cholesterol as risk factors for gastric_cancer in a Chinese Han population .
3283935	0	cholesterol	18,29	Apolipoprotein_E	0,16	cholesterol	Apolipoprotein E	MESH:D002784	348	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|dep|protein	Apolipoprotein_E : cholesterol transport protein with expanding role in cell biology .
3600286	0	cholesterol	41,52	Apolipoprotein_E	0,16	cholesterol	Apolipoprotein E	MESH:D002784	348	Chemical	Gene	response|compound|START_ENTITY END_ENTITY|dobj|response	Apolipoprotein_E polymorphism and plasma cholesterol response to probucol .
7585301	0	cholesterol	49,60	Apolipoprotein_E	0,16	cholesterol	Apolipoprotein E	MESH:D002784	348	Chemical	Gene	response|compound|START_ENTITY END_ENTITY|dobj|response	Apolipoprotein_E polymorphism and dietary plasma cholesterol response .
8172880	0	cholesterol	91,102	Apolipoprotein_E	0,16	cholesterol	Apolipoprotein E	MESH:D002784	348	Chemical	Gene	content|compound|START_ENTITY associated|nmod|content associated|nsubjpass|expression expression|amod|END_ENTITY	Apolipoprotein_E expression in Y1 adrenal cells is associated with increased intracellular cholesterol content and reduced free cholesterol efflux .
8462379	0	cholesterol	56,67	Apolipoprotein_E	0,16	cholesterol	Apolipoprotein E	MESH:D002784	348	Chemical	Gene	response|compound|START_ENTITY associated|nmod|response associated|nsubjpass|polymorphism polymorphism|compound|END_ENTITY	Apolipoprotein_E polymorphism is associated with plasma cholesterol response in a 7-day hospitalization study for metabolic and dietary control in NIDDM .
8910497	0	cholesterol	128,139	Apolipoprotein_E	0,16	cholesterol	Apolipoprotein E	MESH:D002784	348	Chemical	Gene	acceptors|compound|START_ENTITY absence|nmod|acceptors occurs|nmod|absence efflux|acl:relcl|occurs mediates|dobj|efflux mediates|nsubj|END_ENTITY	Apolipoprotein_E produced by human monocyte-derived macrophages mediates cholesterol efflux that occurs in the absence of added cholesterol acceptors .
8910497	0	cholesterol	73,84	Apolipoprotein_E	0,16	cholesterol	Apolipoprotein E	MESH:D002784	348	Chemical	Gene	efflux|compound|START_ENTITY mediates|dobj|efflux mediates|nsubj|END_ENTITY	Apolipoprotein_E produced by human monocyte-derived macrophages mediates cholesterol efflux that occurs in the absence of added cholesterol acceptors .
9868977	0	cholesterol	70,81	Apolipoprotein_E	0,16	cholesterol	Apolipoprotein E	MESH:D002784	348	Chemical	Gene	determinant|nmod|START_ENTITY determinant|nsubj|genotype genotype|amod|END_ENTITY	Apolipoprotein_E genotype is a determinant of low-density lipoprotein cholesterol and of its response to a low-cholesterol diet in Type 1 diabetic patients with elevated urinary albumin excretion .
26100206	7	cholesterol	992,1003	BSA	980,983	cholesterol	ASF	MESH:D002784	6426	Chemical	Gene	efflux|compound|START_ENTITY efflux|compound|END_ENTITY	ASF at its effective concentrations notably reduced the bicarbonate and BSA induced cholesterol efflux .
18084240	0	cholesterol	75,86	Bax	0,3	cholesterol	Bax	MESH:D002784	581	Chemical	Gene	accumulation|nmod|START_ENTITY delayed|nmod|accumulation delayed|nsubj|activation activation|amod|END_ENTITY	Bax activation and stress-induced apoptosis delayed by the accumulation of cholesterol in mitochondrial membranes .
17567802	0	cholesterol	44,55	Brain-derived_neurotrophic_factor	0,33	cholesterol	Brain-derived neurotrophic factor	MESH:D002784	627	Chemical	Gene	metabolism|compound|START_ENTITY regulates|dobj|metabolism regulates|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor regulates cholesterol metabolism for synapse development .
12102655	0	cholesterol	95,106	C-reactive_protein	11,29	cholesterol	C-reactive protein	MESH:D002784	1401	Chemical	Gene	identification|nmod|START_ENTITY identification|dep|Binding Binding|nmod|END_ENTITY	Binding of C-reactive_protein to modified low-density-lipoprotein particles : identification of cholesterol as a novel ligand for C-reactive_protein .
12102655	0	cholesterol	95,106	C-reactive_protein	129,147	cholesterol	C-reactive protein	MESH:D002784	1401	Chemical	Gene	identification|nmod|START_ENTITY identification|acl|ligand ligand|nmod|END_ENTITY	Binding of C-reactive_protein to modified low-density-lipoprotein particles : identification of cholesterol as a novel ligand for C-reactive_protein .
12234946	0	cholesterol	103,114	C-reactive_protein	19,37	cholesterol	C-reactive protein	MESH:D002784	1401	Chemical	Gene	reduction|compound|START_ENTITY independent|nmod|reduction END_ENTITY|dep|independent	Simvastatin lowers C-reactive_protein within 14 days : an effect independent of low-density lipoprotein cholesterol reduction .
12432042	0	cholesterol	61,72	C-reactive_protein	14,32	cholesterol	C-reactive protein	MESH:D002784	1401	Chemical	Gene	levels|compound|START_ENTITY lipoprotein|dobj|levels lipoprotein|nsubj|Comparison Comparison|nmod|END_ENTITY	Comparison of C-reactive_protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular_events .
14609606	0	cholesterol	47,58	C-reactive_protein	90,108	cholesterol	C-reactive protein	MESH:D002784	1401	Chemical	Gene	lowering|dobj|START_ENTITY Usefulness|acl|lowering Usefulness|nmod|END_ENTITY	Usefulness of lowering low-density lipoprotein cholesterol to < 70 mg/dl and usefulness of C-reactive_protein in patient selection .
15667581	0	cholesterol	49,60	C-reactive_protein	15,33	cholesterol	C-reactive protein	MESH:D002784	1401	Chemical	Gene	concentrations|compound|START_ENTITY END_ENTITY|nmod|concentrations	High levels of C-reactive_protein with low total cholesterol concentrations additively predict all-cause mortality in patients with coronary_artery_disease .
15766555	0	cholesterol	50,61	C-reactive_protein	0,18	cholesterol	C-reactive protein	MESH:D002784	1401	Chemical	Gene	group|nmod|START_ENTITY binds|nmod|group binds|amod|END_ENTITY	C-reactive_protein binds to the 3beta-OH group of cholesterol in LDL particles .
16337748	0	cholesterol	19,30	C-reactive_protein	59,77	cholesterol	C-reactive protein	MESH:D002784	1401	Chemical	Gene	Rapid|nmod|START_ENTITY Rapid|dep|role role|nmod|END_ENTITY	Rapid recycling of cholesterol : the joint biologic role of C-reactive_protein and serum_amyloid_A .
17557140	0	cholesterol	141,152	C-reactive_protein	94,112	cholesterol	C-reactive protein	MESH:D002784	1401	Chemical	Gene	levels|compound|START_ENTITY lipoprotein|dobj|levels lipoprotein|nmod|END_ENTITY	Comparison of relative and attributable risk of myocardial_infarction and stroke according to C-reactive_protein and low-density lipoprotein cholesterol levels .
17560879	0	cholesterol	145,156	C-reactive_protein	98,116	cholesterol	C-reactive protein	MESH:D002784	1401	Chemical	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Comparison of effects of ezetimibe/simvastatin versus simvastatin versus atorvastatin in reducing C-reactive_protein and low-density lipoprotein cholesterol levels .
18096828	0	cholesterol	28,39	C-reactive_protein	0,18	cholesterol	C-reactive protein	MESH:D002784	1401	Chemical	Gene	efflux|compound|START_ENTITY inhibits|dobj|efflux inhibits|nsubj|END_ENTITY	C-reactive_protein inhibits cholesterol efflux from human macrophage-derived foam cells .
18164328	0	cholesterol	79,90	C-reactive_protein	9,27	cholesterol	C-reactive protein	MESH:D002784	1401	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubj|END_ENTITY	Elevated C-reactive_protein associated with decreased high-density lipoprotein cholesterol in men with spinal_cord_injury .
19074519	0	cholesterol	123,134	C-reactive_protein	0,18	cholesterol	C-reactive protein	MESH:D002784	1401	Chemical	Gene	pressure|compound|START_ENTITY total|dobj|pressure high|advcl|total high|nsubj|concentrations concentrations|amod|END_ENTITY	C-reactive_protein concentrations are very high and more stable over time than the traditional vascular risk factors total cholesterol and systolic blood pressure in an Australian aboriginal cohort .
19411120	0	cholesterol	6,17	C-reactive_protein	139,157	cholesterol	C-reactive protein	MESH:D002784	1401	Chemical	Gene	levels|compound|START_ENTITY associated|nsubjpass|levels associated|nmod|presence presence|nmod|END_ENTITY	Total cholesterol content_of_erythrocyte_membranes levels are associated with the presence of acute_coronary_syndrome and high sensitivity C-reactive_protein .
19619706	0	cholesterol	89,100	C-reactive_protein	0,18	cholesterol	C-reactive protein	MESH:D002784	1401	Chemical	Gene	mortality|nmod|START_ENTITY predicts|dobj|mortality predicts|nsubj|END_ENTITY	C-reactive_protein predicts long-term mortality independently of low-density lipoprotein cholesterol in patients undergoing percutaneous coronary intervention .
19800416	0	cholesterol	119,130	C-reactive_protein	91,109	cholesterol	C-reactive protein	MESH:D002784	1401	Chemical	Gene	modifies|nmod|START_ENTITY modifies|dobj|relationship relationship|nmod|END_ENTITY	Plasma lecithin : cholesterol acyltransferase activity modifies the inverse relationship of C-reactive_protein with HDL cholesterol in nondiabetic men .
19800416	0	cholesterol	17,28	C-reactive_protein	91,109	cholesterol	C-reactive protein	MESH:D002784	1401	Chemical	Gene	activity|compound|START_ENTITY modifies|nsubj|activity modifies|dobj|relationship relationship|nmod|END_ENTITY	Plasma lecithin : cholesterol acyltransferase activity modifies the inverse relationship of C-reactive_protein with HDL cholesterol in nondiabetic men .
19937457	0	cholesterol	57,68	C-reactive_protein	31,49	cholesterol	C-reactive protein	MESH:D002784	1401	Chemical	Gene	total_antioxidant_status|compound|START_ENTITY total_antioxidant_status|amod|END_ENTITY	The effect of balneotherapy on C-reactive_protein , serum cholesterol , triglyceride , total_antioxidant_status and HSP-60 levels .
21310313	0	cholesterol	105,116	C-reactive_protein	26,44	cholesterol	C-reactive protein	MESH:D002784	1401	Chemical	Gene	levels|compound|START_ENTITY patients|nmod|levels cost-effectiveness|nmod|patients cost-effectiveness|nmod|testing testing|amod|END_ENTITY	The cost-effectiveness of C-reactive_protein testing and rosuvastatin treatment for patients with normal cholesterol levels .
21440886	0	cholesterol	56,67	C-reactive_protein	9,27	cholesterol	C-reactive protein	MESH:D002784	1401	Chemical	Gene	goals|compound|START_ENTITY goals|compound|END_ENTITY	Reaching C-reactive_protein and low-density lipoprotein cholesterol goals in dyslipidemic patients -LRB- from the Lipid Treatment Assessment Project -LSB- L-TAP -RSB- 2 -RRB- .
21676965	0	cholesterol	99,110	C-reactive_protein	0,18	cholesterol	C-reactive protein	MESH:D002784	1401	Chemical	Gene	predicts|nmod|START_ENTITY predicts|nsubj|END_ENTITY	C-reactive_protein predicts the severity of coronary_artery_disease beyond low-density lipoprotein cholesterol .
23507424	0	cholesterol	63,74	C-reactive_protein	111,129	cholesterol	C-reactive protein	MESH:D002784	1401	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	Effects of ezetimibe on markers of synthesis and absorption of cholesterol in high-risk patients with elevated C-reactive_protein .
23604041	0	cholesterol	139,150	C-reactive_protein	10,28	cholesterol	C-reactive protein	MESH:D002784	1401	Chemical	Gene	levels|compound|START_ENTITY carotid|nmod|levels carotid|nsubj|associates associates|amod|END_ENTITY	Increased C-reactive_protein associates with elevated carotid intima-media_thickness in Chinese adults with normal low density lipoprotein cholesterol levels .
23716069	0	cholesterol	26,37	C-reactive_protein	107,125	cholesterol	C-reactive protein	MESH:D002784	1401	Chemical	Gene	cholesterol|compound|START_ENTITY Analysis|nmod|cholesterol changes|nsubj|Analysis changes|nmod|range range|nmod|levels levels|amod|END_ENTITY	Analysis and modelling of cholesterol and high-density lipoprotein cholesterol changes across the range of C-reactive_protein levels in clinical practice as an aid to better understanding of inflammation-lipid interactions .
23716069	0	cholesterol	67,78	C-reactive_protein	107,125	cholesterol	C-reactive protein	MESH:D002784	1401	Chemical	Gene	Analysis|nmod|START_ENTITY changes|nsubj|Analysis changes|nmod|range range|nmod|levels levels|amod|END_ENTITY	Analysis and modelling of cholesterol and high-density lipoprotein cholesterol changes across the range of C-reactive_protein levels in clinical practice as an aid to better understanding of inflammation-lipid interactions .
25911075	0	cholesterol	46,57	C-reactive_protein	90,108	cholesterol	C-reactive protein	MESH:D002784	1401	Chemical	Gene	ratio|compound|START_ENTITY lipoprotein|dep|ratio predicts|nsubj|lipoprotein predicts|dobj|levels levels|amod|END_ENTITY	Total cholesterol-to-high-density lipoprotein cholesterol ratio predicts high-sensitivity C-reactive_protein levels in Turkish children .
26379442	0	cholesterol	62,73	C-reactive_protein	0,18	cholesterol	C-reactive protein	MESH:D002784	1401	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	C-reactive_protein is associated with low-density lipoprotein cholesterol and obesity in type 2 diabetic Sudanese .
7382134	0	cholesterol	99,110	C-reactive_protein	58,76	cholesterol	C-reactive protein	MESH:D002784	1401	Chemical	Gene	mediated|nmod|START_ENTITY mediated|nmod|END_ENTITY	Change in permeability of liposomal membranes mediated by C-reactive_protein and its inhibition by cholesterol .
9610529	0	cholesterol	65,76	C-reactive_protein	0,18	cholesterol	C-reactive protein	MESH:D002784	1401	Chemical	Gene	value|nmod|START_ENTITY adds|nmod|value adds|nsubj|END_ENTITY	C-reactive_protein adds to the predictive value of total and HDL cholesterol in determining risk of first myocardial_infarction .
17012138	0	cholesterol	34,45	CD40	15,19	cholesterol	CD40	MESH:D002784	958	Chemical	Gene	metabolism|compound|START_ENTITY related|nmod|metabolism related|nsubjpass|END_ENTITY	Plasma-soluble CD40 is related to cholesterol metabolism in patients with moderate hypercholesterolemia .
20332533	0	cholesterol	88,99	CETP	123,127	cholesterol	CETP	MESH:D002784	1071	Chemical	Gene	START_ENTITY|nmod|transgenic_mice transgenic_mice|compound|END_ENTITY	Selective CETP inhibition and PPARalpha agonism increase HDL cholesterol and reduce LDL cholesterol in human ApoB100/human CETP transgenic_mice .
26086093	0	cholesterol	14,25	CXCL8	48,53	cholesterol	CXCL8	MESH:D002784	3576	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	27-Oxygenated cholesterol induces expression of CXCL8 in macrophages via NF-kB and CD88 .
12161514	0	cholesterol	39,50	CYP11A	84,90	cholesterol	CYP11A	MESH:D002784	1583	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Compound heterozygous mutations in the cholesterol side-chain cleavage enzyme gene -LRB- CYP11A -RRB- cause congenital_adrenal_insufficiency in humans .
1333053	0	cholesterol	76,87	CYP11A	68,74	cholesterol	CYP11A	MESH:D002784	1583	Chemical	Gene	chain|compound|START_ENTITY gene|dep|chain gene|amod|END_ENTITY	3 ' ,5 ' - cyclic_adenosine_monophosphate-dependent transcription of the CYP11A -LRB- cholesterol side chain cleavage cytochrome P450 -RRB- gene involves a DNA response element containing a putative binding site for transcription factor Sp1 .
15319355	0	cholesterol	71,82	CYP11A	104,110	cholesterol	CYP11A	MESH:D002784	1583	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Up-regulation of basal transcriptional activity of the cytochrome P450 cholesterol side-chain cleavage -LRB- CYP11A -RRB- gene by isoform-specific calcium-calmodulin-dependent protein kinase in primary cultures of ovarian granulosa cells .
7629150	0	cholesterol	120,131	CYP11A1	153,160	cholesterol	CYP11A1	MESH:D002784	1583	Chemical	Gene	promoter|compound|START_ENTITY promoter|appos|END_ENTITY	Epidermal_growth_factor and c-Jun act via a common DNA regulatory element to stimulate transcription of the ovine P-450 cholesterol side chain cleavage -LRB- CYP11A1 -RRB- promoter .
16340204	0	cholesterol	20,31	CYP46A1	54,61	cholesterol	CYP46A1	MESH:D002784	10858	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Polymorphism in the cholesterol 24S-hydroxylase gene -LRB- CYP46A1 -RRB- associated with the APOEpsilon3 allele increases the risk of Alzheimer 's _ disease and of mild_cognitive_impairment progressing to Alzheimer 's _ disease .
16734927	0	cholesterol	21,32	CYP46A1	49,56	cholesterol	CYP46A1	MESH:D002784	10858	Chemical	Gene	START_ENTITY|dep|gene gene|appos|END_ENTITY	Polymorphisms of the cholesterol 24-hydroxylase -LRB- CYP46A1 -RRB- gene and the risk of Alzheimer 's _ disease in a Chinese population .
19553612	0	cholesterol	46,57	CYP46A1	75,82	cholesterol	CYP46A1	MESH:D002784	10858	Chemical	Gene	association|nmod|START_ENTITY polymorphism|amod|association polymorphism|appos|END_ENTITY	Primary open-angle_glaucoma : association with cholesterol 24S-hydroxylase -LRB- CYP46A1 -RRB- gene polymorphism and plasma 24-hydroxycholesterol levels .
20667828	0	cholesterol	69,80	CYP46A1	36,43	cholesterol	CYP46A1	MESH:D002784	10858	Chemical	Gene	turnover|compound|START_ENTITY controls|dobj|turnover enzyme|acl:relcl|controls END_ENTITY|appos|enzyme	Structural basis of drug binding to CYP46A1 , an enzyme that controls cholesterol turnover in the brain .
20930312	0	cholesterol	84,95	CYP46A1	53,60	cholesterol	CYP46A1	MESH:D002784	10858	Chemical	Gene	elimination|compound|START_ENTITY player|nmod|elimination END_ENTITY|appos|player	Chromatin-modifying agents increase transcription of CYP46A1 , a key player in brain cholesterol elimination .
21531213	0	cholesterol	85,96	CYP46A1	56,63	cholesterol	CYP46A1	MESH:D002784	10858	Chemical	Gene	retina|nmod|START_ENTITY 24S-hydroxycholesterol|nmod|retina 24S-hydroxycholesterol|appos|END_ENTITY	24S-hydroxycholesterol and cholesterol-24S-hydroxylase -LRB- CYP46A1 -RRB- in the retina : from cholesterol homeostasis to pathophysiology of glaucoma .
23874659	0	cholesterol	65,76	CYP46A1	94,101	cholesterol	CYP46A1	MESH:D002784	13116(Tax:10090)	Chemical	Gene	24S-hydroxylase|compound|START_ENTITY 24S-hydroxylase|appos|END_ENTITY	Is it possible to improve memory function by upregulation of the cholesterol 24S-hydroxylase -LRB- CYP46A1 -RRB- in the brain ?
24491555	0	cholesterol	92,103	CYP46A1	53,60	cholesterol	CYP46A1	MESH:D002784	362782(Tax:10116)	Chemical	Gene	voriconazole|nmod|START_ENTITY inhibition|nmod|voriconazole inhibition|appos|END_ENTITY	In vivo consequences of cholesterol-24S-hydroxylase -LRB- CYP46A1 -RRB- inhibition by voriconazole on cholesterol homeostasis and function in the rat retina .
25514969	0	cholesterol	27,38	CYP46A1	55,62	cholesterol	CYP46A1	MESH:D002784	10858	Chemical	Gene	24-hydroxylase|advmod|START_ENTITY inhibitors|amod|24-hydroxylase inhibitors|appos|END_ENTITY	Imidazo -LSB- 1,2-a -RSB- pyridines as cholesterol 24-hydroxylase -LRB- CYP46A1 -RRB- inhibitors : a patent evaluation -LRB- WO2014061676 -RRB- .
26912634	0	cholesterol	38,49	CYP46A1	0,7	cholesterol	CYP46A1	MESH:D002784	13116(Tax:10090)	Chemical	Gene	degradation|compound|START_ENTITY enzyme|nmod|degradation END_ENTITY|appos|enzyme	CYP46A1 , the rate-limiting enzyme for cholesterol degradation , is neuroprotective in Huntington 's _ disease .
21912424	0	cholesterol	60,71	CYP4A11	0,7	cholesterol	CYP4A11	MESH:D002784	1579	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|variant variant|compound|END_ENTITY	CYP4A11 variant is associated with high-density lipoprotein cholesterol in women .
24358204	0	cholesterol	30,41	CYP51A1	17,24	cholesterol	CYP51A1	MESH:D002784	1595	Chemical	Gene	synthesis|compound|START_ENTITY END_ENTITY|nmod|synthesis	Polymorphisms of CYP51A1 from cholesterol synthesis : associations with birth weight and maternal lipid levels and impact on CYP51 protein structure .
18374163	0	cholesterol	25,36	Cdc42	16,21	cholesterol	Cdc42	MESH:D002784	998	Chemical	Gene	efflux|compound|START_ENTITY END_ENTITY|nmod|efflux	Contribution of Cdc42 to cholesterol efflux in fibroblasts from Tangier_disease and Werner_syndrome .
8354954	0	cholesterol	76,87	Cholesterol_7_alpha-hydroxylase	0,31	cholesterol	Cholesterol 7 alpha-hydroxylase	MESH:D002784	25428(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY evidence|nmod|regulation END_ENTITY|dep|evidence	Cholesterol_7_alpha-hydroxylase : evidence for transcriptional regulation by cholesterol or metabolic products of cholesterol in the rat .
12031288	0	cholesterol	44,55	Cholesterol_esterase	0,20	cholesterol	Cholesterol esterase	MESH:D002784	1056	Chemical	Gene	absorption|compound|START_ENTITY accelerates|dobj|absorption accelerates|nsubj|END_ENTITY	Cholesterol_esterase accelerates intestinal cholesterol absorption .
14646197	0	cholesterol	110,121	Cholesterol_esterase	0,20	cholesterol	Cholesterol esterase	MESH:D002784	24254(Tax:10116)	Chemical	Gene	incorporation|nmod|START_ENTITY accelerate|dobj|incorporation accelerate|nsubj|END_ENTITY	Cholesterol_esterase bound to intestinal brush border membranes does not accelerate incorporation of micellar cholesterol into absorptive cells .
7696259	0	cholesterol	24,35	Cholesterol_esterase	0,20	cholesterol	Cholesterol esterase	MESH:D002784	24254(Tax:10116)	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|dep|protein	Cholesterol_esterase : a cholesterol transfer protein .
15857309	0	cholesterol	92,103	Cholesteryl_ester_transfer_protein	0,34	cholesterol	Cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	levels|compound|START_ENTITY modulation|nmod|levels inhibition|nmod|modulation END_ENTITY|dep|inhibition	Cholesteryl_ester_transfer_protein : pharmacological inhibition for the modulation of plasma cholesterol levels and promising target for the prevention of atherosclerosis .
21454568	0	cholesterol	119,130	Cholesteryl_ester_transfer_protein	0,34	cholesterol	Cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	metabolism|compound|START_ENTITY attenuates|nmod|metabolism attenuates|nsubj|expression expression|compound|END_ENTITY	Cholesteryl_ester_transfer_protein expression partially attenuates the adverse effects of SR-BI receptor deficiency on cholesterol metabolism and atherosclerosis .
16844298	0	cholesterol	107,118	Cyp11a	98,104	cholesterol	Cyp11a	MESH:D002784	29680(Tax:10116)	Chemical	Gene	enzyme|compound|START_ENTITY reduces|nsubj|enzyme reduces|nmod|down-regulation down-regulation|nmod|END_ENTITY	Vitamin_K_deficiency reduces testosterone production in the testis through down-regulation of the Cyp11a a cholesterol side chain cleavage enzyme in rats .
25065682	0	cholesterol	102,113	Cyp27a1	39,46	cholesterol	Cyp27a1	MESH:D002784	104086(Tax:10090)	Chemical	Gene	abnormalities|nmod|START_ENTITY abnormalities|nmod|mice mice|amod|END_ENTITY	Retinal and nonocular abnormalities in Cyp27a1 -LRB- - / - -RRB- Cyp46a1 -LRB- - / - -RRB- mice with dysfunctional metabolism of cholesterol .
25065682	0	cholesterol	102,113	Cyp46a1	51,58	cholesterol	Cyp46a1	MESH:D002784	13116(Tax:10090)	Chemical	Gene	abnormalities|nmod|START_ENTITY abnormalities|nmod|mice mice|amod|END_ENTITY	Retinal and nonocular abnormalities in Cyp27a1 -LRB- - / - -RRB- Cyp46a1 -LRB- - / - -RRB- mice with dysfunctional metabolism of cholesterol .
18633604	0	cholesterol	58,69	Cytochrome_P450	0,15	cholesterol	Cytochrome P450	MESH:D002784	4051	Chemical	Gene	elimination|compound|START_ENTITY pharmacology|nmod|elimination activation|nmod|pharmacology activation|compound|END_ENTITY	Cytochrome_P450 and gene activation -- from pharmacology to cholesterol elimination and regression of atherosclerosis .
21712389	0	cholesterol	41,52	Early_growth_response_1	0,23	cholesterol	Early growth response 1	MESH:D002784	13653(Tax:10090)	Chemical	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Early_growth_response_1 -LRB- Egr1 -RRB- regulates cholesterol biosynthetic gene expression .
24843417	0	cholesterol	31,42	Endothelial_lipase	0,18	cholesterol	Endothelial lipase	MESH:D002784	9388	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|dobj|transport	Endothelial_lipase and reverse cholesterol transport in type_2_diabetes_mellitus .
25451482	0	cholesterol	29,40	FOXJ2	63,68	cholesterol	FOXJ2	MESH:D002784	55810	Chemical	Gene	synthesis|compound|START_ENTITY synthesis|nmod|END_ENTITY	STAT6 silencing up-regulates cholesterol synthesis via miR-197 / FOXJ2 axis and induces ER stress-mediated apoptosis in lung_cancer cells .
24404629	0	cholesterol	132,143	Familial_Hypercholesterolemia	0,29	cholesterol	Familial Hypercholesterolemia	MESH:D002784	3949	Chemical	Gene	levels|compound|START_ENTITY characterized|nmod|levels CHARACTERISTICS|parataxis|characterized CHARACTERISTICS|nsubj|DISEASE DISEASE|compound|END_ENTITY	Familial_Hypercholesterolemia DISEASE CHARACTERISTICS : Familial_hypercholesterolemia -LRB- FH -RRB- is characterized by severely elevated LDL cholesterol -LRB- LDL-C -RRB- levels that cause atherosclerotic plaque deposition in arteries and a markedly increased risk of coronary_artery_disease at an early age .
22713451	0	cholesterol	36,47	Fibroblast_growth_factor_7	0,26	cholesterol	Fibroblast growth factor 7	MESH:D002784	2252	Chemical	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Fibroblast_growth_factor_7 inhibits cholesterol 7a-hydroxylase gene expression in hepatocytes .
25232378	0	cholesterol	26,37	G-CSF	11,16	cholesterol	G-CSF	MESH:D002784	12985(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of G-CSF on serum cholesterol and development of atherosclerotic plaque in apolipoprotein_E-deficient mice .
21296663	0	cholesterol	41,52	Gonadotropin-releasing_hormone	0,30	cholesterol	Gonadotropin-releasing hormone	MESH:D002784	2796	Chemical	Gene	synthesis|compound|START_ENTITY modulates|dobj|synthesis modulates|nsubj|END_ENTITY	Gonadotropin-releasing_hormone modulates cholesterol synthesis and steroidogenesis in SH-SY5Y cells .
10199770	0	cholesterol	96,107	Growth_hormone	0,14	cholesterol	Growth hormone	MESH:D002784	2688	Chemical	Gene	load|nmod|START_ENTITY influences|nmod|load influences|nsubj|therapy therapy|amod|END_ENTITY	Growth_hormone -LRB- GH -RRB- therapy in GH-deficient adults influences the response to a dietary load of cholesterol and saturated fat in terms of cholesterol synthesis , but not serum low density lipoprotein cholesterol levels .
10469010	0	cholesterol	76,87	Growth_hormone	0,14	cholesterol	Growth hormone	MESH:D002784	2688	Chemical	Gene	levels|nmod|START_ENTITY determinant|nmod|levels determinant|nsubj|status status|amod|END_ENTITY	Growth_hormone -LRB- GH -RRB- status is an independent determinant of serum levels of cholesterol and triglycerides in healthy adults .
11134128	0	cholesterol	75,86	Growth_hormone	0,14	cholesterol	Growth hormone	MESH:D002784	2688	Chemical	Gene	concentration|compound|START_ENTITY decreases|dobj|concentration decreases|nsubj|treatment treatment|amod|END_ENTITY	Growth_hormone -LRB- GH -RRB- treatment decreases postprandial remnant-like particle cholesterol concentration and improves endothelial function in adult-onset GH_deficiency .
11387232	0	cholesterol	30,41	Growth_hormone	0,14	cholesterol	Growth hormone	MESH:D002784	14599(Tax:10090)	Chemical	Gene	reduces|dobj|START_ENTITY reduces|nsubj|END_ENTITY	Growth_hormone reduces plasma cholesterol in LDL_receptor-deficient mice .
2403660	0	cholesterol	125,136	HDL2	120,124	cholesterol	HDL2	MESH:D002784	57338	Chemical	Gene	level|compound|START_ENTITY level|compound|END_ENTITY	The ratio of waist-to-hip circumference , plasma insulin level , and glucose_intolerance as independent predictors of the HDL2 cholesterol level in older adults .
2445254	0	cholesterol	87,98	HDL2	77,81	cholesterol	HDL2	MESH:D002784	57338	Chemical	Gene	ratios|compound|START_ENTITY END_ENTITY|dep|ratios	Further evidence for the heterogeneity of high density lipoprotein isolates : HDL2 : HDL3 cholesterol ratios and the presence of apolipoprotein_B .
6454513	0	cholesterol	21,32	HDL2	82,86	cholesterol	HDL2	MESH:D002784	57338	Chemical	Gene	content|compound|START_ENTITY content|nmod|END_ENTITY	Determination of the cholesterol content of high density lipoprotein subfractions HDL2 and HDL3 , without contamination of Lp -LRB- a -RRB- , in human plasma .
6488565	0	cholesterol	4,15	HDL2	27,31	cholesterol	HDL2	MESH:D002784	57338	Chemical	Gene	content|compound|START_ENTITY content|nmod|END_ENTITY	The cholesterol content of HDL2 and HDL3 subfractions of high density lipoproteins in different normocholesterolemic populations .
6697533	0	cholesterol	28,39	HDL2	14,18	cholesterol	HDL2	MESH:D002784	57338	Chemical	Gene	START_ENTITY|nsubj|Evaluation Evaluation|nmod|END_ENTITY	Evaluation of HDL2 and HDL3 cholesterol by a precipitation procedure in a normal population and in different hyperlipidemic phenotypes .
7284053	0	cholesterol	48,59	HDL2	34,38	cholesterol	HDL2	MESH:D002784	57338	Chemical	Gene	concentration|compound|START_ENTITY concentration|compound|END_ENTITY	Similarity of male and females of HDL2 and HDL3 cholesterol concentration in A caribbean rural community .
7614418	0	cholesterol	55,66	HDL3	50,54	cholesterol	HDL3	MESH:D002784	53369	Chemical	Gene	concentrations|compound|START_ENTITY END_ENTITY|dobj|concentrations	A relationship between aortic_stiffness and serum HDL3 cholesterol concentrations in hypercholesterolaemic , symptom-free men .
24632196	0	cholesterol	34,45	HIF-1	14,19	cholesterol	HIF-1	MESH:D002784	3091	Chemical	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Mechanism for HIF-1 activation by cholesterol under normoxia : a redox signaling pathway for liver_damage .
10884284	0	cholesterol	39,50	HMG-CoA_reductase	95,112	cholesterol	HMG-CoA reductase	MESH:D002784	25675(Tax:10116)	Chemical	Gene	synthesis|compound|START_ENTITY changes|nmod|synthesis correlate|nsubj|changes correlate|nmod|levels levels|nmod|mRNA mRNA|nmod|END_ENTITY	Diurnal and dietary-induced changes in cholesterol synthesis correlate with levels of mRNA for HMG-CoA_reductase .
12042421	0	cholesterol	40,51	HMG-CoA_reductase	78,95	cholesterol	HMG-CoA reductase	MESH:D002784	25675(Tax:10116)	Chemical	Gene	synthesis|compound|START_ENTITY inhibit|dobj|synthesis inhibit|advcl|deactivating deactivating|dobj|END_ENTITY	S-alk -LRB- en -RRB- yl_cysteines of garlic inhibit cholesterol synthesis by deactivating HMG-CoA_reductase in cultured rat hepatocytes .
14977441	0	cholesterol	178,189	HMG-CoA_reductase	80,97	cholesterol	HMG-CoA reductase	MESH:D002784	25675(Tax:10116)	Chemical	Gene	diets|compound|START_ENTITY fed|dobj|diets Effects|acl|fed Effects|nmod|END_ENTITY	Effects of manufactured soluble dietary fiber from Quercus mongolica on hepatic HMG-CoA_reductase and lipoprotein_lipase activities in epididymal adipose tissue of rats fed high cholesterol diets .
15096652	0	cholesterol	33,44	HMG-CoA_reductase	116,133	cholesterol	HMG-CoA reductase	MESH:D002784	25675(Tax:10116)	Chemical	Gene	sensitivity|nmod|START_ENTITY associated|nsubj|sensitivity associated|nmod|levels levels|nmod|expression expression|amod|END_ENTITY	Increased sensitivity to dietary cholesterol in diabetic and hypothyroid rats associated with low levels of hepatic HMG-CoA_reductase expression .
15096653	0	cholesterol	63,74	HMG-CoA_reductase	8,25	cholesterol	HMG-CoA reductase	MESH:D002784	25675(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY END_ENTITY|dep|expression	Hepatic HMG-CoA_reductase expression and resistance to dietary cholesterol .
15977099	0	cholesterol	8,19	HMG-CoA_reductase	44,61	cholesterol	HMG-CoA reductase	MESH:D002784	3156	Chemical	Gene	START_ENTITY|acl|lowering lowering|nmod|inhibitor inhibitor|amod|END_ENTITY	Intense cholesterol lowering therapy with a HMG-CoA_reductase inhibitor does not improve nitric_oxide dependent endothelial function in type-2-diabetes -- a multicenter , randomised , double-blind , three-arm placebo-controlled clinical trial .
16503864	0	cholesterol	119,130	HMG-CoA_reductase	0,17	cholesterol	HMG-CoA reductase	MESH:D002784	3156	Chemical	Gene	induced|nmod|START_ENTITY atherosclerosis|acl|induced effects|nmod|atherosclerosis inhibitors|dep|effects inhibitors|amod|END_ENTITY	HMG-CoA_reductase inhibitors : effects on chronic_subacute_inflammation and onset of atherosclerosis induced by dietary cholesterol .
16636304	0	cholesterol	91,102	HMG-CoA_reductase	44,61	cholesterol	HMG-CoA reductase	MESH:D002784	25675(Tax:10116)	Chemical	Gene	absorption|compound|START_ENTITY inhibition|nmod|absorption compensatory|nmod|inhibition compensatory|dobj|induction induction|nmod|END_ENTITY	Selective compensatory induction of hepatic HMG-CoA_reductase in response to inhibition of cholesterol absorption .
1805095	0	cholesterol	159,170	HMG-CoA_reductase	131,148	cholesterol	HMG-CoA reductase	MESH:D002784	25675(Tax:10116)	Chemical	Gene	acyltransferase|compound|START_ENTITY acyltransferase|amod|END_ENTITY	Effects of perturbations in hepatic free and esterified cholesterol pools on bile_acid synthesis , cholesterol_7_alpha-hydroxylase , HMG-CoA_reductase , acyl-CoA : cholesterol acyltransferase and cytosolic cholesteryl_ester hydrolase .
18270459	0	cholesterol	58,69	HMG-CoA_reductase	0,17	cholesterol	HMG-CoA reductase	MESH:D002784	3156	Chemical	Gene	transport|compound|START_ENTITY improves|dobj|transport improves|nsubj|inhibitor inhibitor|amod|END_ENTITY	HMG-CoA_reductase inhibitor , simvastatin improves reverse cholesterol transport in type 2 diabetic patients with hyperlipidemia .
2090716	0	cholesterol	22,33	HMG-CoA_reductase	97,114	cholesterol	HMG-CoA reductase	MESH:D002784	3156	Chemical	Gene	metabolism|compound|START_ENTITY Regulation|nmod|metabolism Regulation|dep|effects effects|nmod|cholestyramine cholestyramine|nmod|activity activity|amod|END_ENTITY	Regulation of hepatic cholesterol metabolism in humans : stimulatory effects of cholestyramine on HMG-CoA_reductase activity and low_density_lipoprotein_receptor expression in gallstone patients .
21178122	4	cholesterol	553,564	HMG-CoA_reductase	499,516	cholesterol	HMG-CoA reductase	MESH:D002784	3156	Chemical	Gene	biosynthesis|compound|START_ENTITY step|nmod|biosynthesis catalyzes|dobj|step catalyzes|nsubj|END_ENTITY	HMG-CoA_reductase catalyzes the rate-limiting step in cholesterol biosynthesis .
23846804	0	cholesterol	88,99	HMG-CoA_reductase	0,17	cholesterol	HMG-CoA reductase	MESH:D002784	3156	Chemical	Gene	efflux|compound|START_ENTITY downregulate|dobj|efflux downregulate|nsubj|inhibitors inhibitors|amod|END_ENTITY	HMG-CoA_reductase inhibitors , simvastatin and atorvastatin , downregulate ABCG1-mediated cholesterol efflux in human macrophages .
23958894	0	cholesterol	71,82	HMG-CoA_reductase	25,42	cholesterol	HMG-CoA reductase	MESH:D002784	15357(Tax:10090)	Chemical	Gene	biosynthesis|compound|START_ENTITY involved|nmod|biosynthesis involved|nsubj|inhibitors inhibitors|nmod|END_ENTITY	Allosteric inhibitors of HMG-CoA_reductase , the key enzyme involved in cholesterol biosynthesis .
25701719	0	cholesterol	37,48	HMG-CoA_reductase	104,121	cholesterol	HMG-CoA reductase	MESH:D002784	25675(Tax:10116)	Chemical	Gene	biosynthesis|compound|START_ENTITY regulation|nmod|biosynthesis regulation|dep|Role Role|nmod|control control|nmod|involvement involvement|amod|END_ENTITY	Physiological feedback regulation of cholesterol biosynthesis : Role of translational control of hepatic HMG-CoA_reductase and possible involvement of oxylanosterols .
2645482	0	cholesterol	56,67	HMG-CoA_reductase	15,32	cholesterol	HMG-CoA reductase	MESH:D002784	3156	Chemical	Gene	lowering|dobj|START_ENTITY inhibitor|acl|lowering inhibitor|amod|END_ENTITY	Lovastatin : an HMG-CoA_reductase inhibitor for lowering cholesterol .
26932266	0	cholesterol	38,49	HMG-CoA_reductase	74,91	cholesterol	HMG-CoA reductase	MESH:D002784	3156	Chemical	Gene	synthesis|compound|START_ENTITY induces|dobj|synthesis induces|advcl|increasing increasing|dobj|expression expression|amod|END_ENTITY	Transforming_growth_factor-b1 induces cholesterol synthesis by increasing HMG-CoA_reductase mRNA expression in keratinocytes .
27003275	0	cholesterol	6,17	HMG-CoA_reductase	26,43	cholesterol	HMG-CoA reductase	MESH:D002784	3156	Chemical	Gene	levels|compound|START_ENTITY levels|appos|inhibitors inhibitors|amod|END_ENTITY	Serum cholesterol levels , HMG-CoA_reductase inhibitors and the risk of intracerebral_haemorrhage .
2836685	0	cholesterol	77,88	HMG-CoA_reductase	30,47	cholesterol	HMG-CoA reductase	MESH:D002784	25675(Tax:10116)	Chemical	Gene	bran|compound|START_ENTITY containing|dobj|bran fed|xcomp|containing fed|nsubj|changes changes|nmod|END_ENTITY	Short-term changes in hepatic HMG-CoA_reductase in rats fed diets containing cholesterol or oat bran .
3009982	0	cholesterol	72,83	HMG-CoA_reductase	18,35	cholesterol	HMG-CoA reductase	MESH:D002784	3156	Chemical	Gene	enzyme|nmod|START_ENTITY synthesis|nsubj|enzyme synthesis|nmod|control control|nmod|END_ENTITY	On the control of HMG-CoA_reductase , a key regulatory enzyme of adrenal cholesterol synthesis .
7712108	0	cholesterol	102,113	HMG-CoA_reductase	80,97	cholesterol	HMG-CoA reductase	MESH:D002784	25675(Tax:10116)	Chemical	Gene	biosynthesis|compound|START_ENTITY differences|nmod|biosynthesis differences|appos|inhibitor inhibitor|nmod|END_ENTITY	Species differences in the inhibiting effect of fluvastatin , a new inhibitor of HMG-CoA_reductase , on cholesterol biosynthesis .
7868973	0	cholesterol	29,40	HMG-CoA_reductase	99,116	cholesterol	HMG-CoA reductase	MESH:D002784	3156	Chemical	Gene	effects|nmod|START_ENTITY biosynthesis|nsubj|effects biosynthesis|nmod|therapy therapy|amod|END_ENTITY	Acute and chronic effects on cholesterol biosynthesis of LDL-apheresis with or without concomitant HMG-CoA_reductase inhibitor therapy .
8960787	0	cholesterol	64,75	HMG-CoA_reductase	11,28	cholesterol	HMG-CoA reductase	MESH:D002784	3156	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|inhibition inhibition|amod|END_ENTITY	Effects of HMG-CoA_reductase inhibition on erythrocyte membrane cholesterol and acyl chain composition .
9125163	0	cholesterol	65,76	HMG-CoA_reductase	36,53	cholesterol	HMG-CoA reductase	MESH:D002784	25675(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Translational regulation of hepatic HMG-CoA_reductase by dietary cholesterol .
9126662	0	cholesterol	55,66	HMG-CoA_reductase	89,106	cholesterol	HMG-CoA reductase	MESH:D002784	3156	Chemical	Gene	reduction|nmod|START_ENTITY associated|nmod|reduction associated|nmod|pravastatin pravastatin|amod|END_ENTITY	Hemodynamic changes associated with reduction in total cholesterol by treatment with the HMG-CoA_reductase inhibitor pravastatin .
20967643	0	cholesterol	66,77	HMGCR	52,57	cholesterol	HMGCR	MESH:D002784	395145(Tax:9031)	Chemical	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	The effect of a mutation in the 3-UTR region of the HMGCR gene on cholesterol in Beijing-you chickens .
21774025	4	cholesterol	549,560	HMGCR	603,608	cholesterol	ACSL3	MESH:D002784	2181	Chemical	Gene	HMG-CoA_reductase|compound|START_ENTITY HMG-CoA_reductase|appos|END_ENTITY	These genes were the cholesterol synthesis-related gene HMG-CoA_reductase -LRB- HMGCR -RRB- , fatty_acid oxidation genes acyl-CoA_synthetase_long-chain_family_member_3 -LRB- ACSL3 -RRB- and long-chain acyl-CoA dehydrogenase -LRB- ACADL -RRB- , glycolytic genes fructose 1,6 bisphosphate aldolase -LRB- ALDOA -RRB- and lactate_dehydrogenase_C -LRB- LDHC -RRB- , and tumor_necrosis_factor-a -LRB- TNF -RRB- .
23696639	0	cholesterol	12,23	HMGCR	83,88	cholesterol	HMGCR	MESH:D002784	3156	Chemical	Gene	synthesis|compound|START_ENTITY Controlling|dobj|synthesis Controlling|nmod|3-hydroxy-3-methylglutaryl-CoA_reductase 3-hydroxy-3-methylglutaryl-CoA_reductase|appos|END_ENTITY	Controlling cholesterol synthesis beyond 3-hydroxy-3-methylglutaryl-CoA_reductase -LRB- HMGCR -RRB- .
24001602	0	cholesterol	68,79	HMGCR	18,23	cholesterol	HMGCR	MESH:D002784	3156	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|amod|END_ENTITY	HNRNPA1 regulates HMGCR alternative splicing and modulates cellular cholesterol metabolism .
25770315	0	cholesterol	71,82	HMGCR	158,163	cholesterol	HMGCR	MESH:D002784	3156	Chemical	Gene	allocation|nmod|START_ENTITY Effect|nmod|allocation mediated|nsubj|Effect mediated|nmod|polymorphisms polymorphisms|nmod|END_ENTITY	Effect of naturally random allocation to lower low-density lipoprotein cholesterol on the risk of coronary_heart_disease mediated by polymorphisms in NPC1L1 , HMGCR , or both : a 2 * 2 factorial Mendelian randomization study .
22444938	0	cholesterol	37,48	HMGR	14,18	cholesterol	HMGR	MESH:D002784	100144446(Tax:9823)	Chemical	Gene	content|compound|START_ENTITY content|compound|END_ENTITY	Expression of HMGR and corresponding cholesterol content in tissues of two pig breeds .
24001602	0	cholesterol	68,79	HNRNPA1	0,7	cholesterol	HNRNPA1	MESH:D002784	3178	Chemical	Gene	metabolism|compound|START_ENTITY regulates|dobj|metabolism regulates|nsubj|END_ENTITY	HNRNPA1 regulates HMGCR alternative splicing and modulates cellular cholesterol metabolism .
12860265	0	cholesterol	77,88	Hepatic_lipase	0,14	cholesterol	Hepatic lipase	MESH:D002784	3990	Chemical	Gene	levels|compound|START_ENTITY changes|nmod|levels influences|dobj|changes influences|nsubj|polymorphism polymorphism|amod|END_ENTITY	Hepatic_lipase promoter C-514T polymorphism influences serial changes in HDL cholesterol levels since childhood : the Bogalusa Heart Study .
1903730	1	cholesterol	217,228	Hepatic_lipase	163,177	cholesterol	hepatic lipase	MESH:D002784	3990	Chemical	Gene	removal|nmod|START_ENTITY involved|nmod|removal involved|nsubjpass|activity activity|compound|END_ENTITY	OBJECTIVE : Hepatic_lipase activity is involved in the removal of cholesterol and phospholipid from plasma high-density lipoprotein -LRB- HDL -RRB- to the liver .
6631221	0	cholesterol	65,76	Hepatic_lipase	0,14	cholesterol	Hepatic lipase	MESH:D002784	24538(Tax:10116)	Chemical	Gene	uptake|nmod|START_ENTITY stimulates|dobj|uptake stimulates|nsubj|END_ENTITY	Hepatic_lipase stimulates the uptake of high density lipoprotein cholesterol by hepatoma cells .
8014574	0	cholesterol	53,64	Hepatic_lipase	0,14	cholesterol	Hepatic lipase	MESH:D002784	24538(Tax:10116)	Chemical	Gene	uptake|nmod|START_ENTITY promotes|dobj|uptake promotes|nsubj|END_ENTITY	Hepatic_lipase promotes the uptake of HDL esterified cholesterol by the perfused rat liver : a study using reconstituted HDL particles of defined phospholipid composition .
8750779	0	cholesterol	93,104	Hepatic_lipase	0,14	cholesterol	Hepatic lipase	MESH:D002784	3990	Chemical	Gene	homeostasis|compound|START_ENTITY related|nmod|homeostasis related|nsubjpass|secretion secretion|amod|END_ENTITY	Hepatic_lipase secretion in human hepatoblastoma cell line Hep G2 is not related to cellular cholesterol homeostasis .
9153204	0	cholesterol	43,54	Hepatic_lipase	0,14	cholesterol	Hepatic lipase	MESH:D002784	15450(Tax:10090)	Chemical	Gene	increases|dobj|START_ENTITY increases|nsubj|deficiency deficiency|amod|END_ENTITY	Hepatic_lipase deficiency increases plasma cholesterol but reduces susceptibility to atherosclerosis in apolipoprotein_E-deficient mice .
22896903	0	cholesterol	10,21	Hsp70	91,96	cholesterol	Hsp70	MESH:D002784	15511(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of cholesterol and 7beta-hydroxycholesterol on glutathione status and expression of Hsp70 in cultured murine peritoneal macrophages .
18483254	0	cholesterol	17,28	Ikaros	0,6	cholesterol	Ikaros	MESH:D002784	22778(Tax:10090)	Chemical	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	Ikaros modulates cholesterol uptake : a link between tumor suppression and differentiation .
11079255	0	cholesterol	105,116	Insulin	0,7	cholesterol	Insulin	MESH:D002784	3630	Chemical	Gene	subjects|nmod|START_ENTITY sensitivity|nmod|subjects sensitivity|nsubj|END_ENTITY	Insulin sensitivity after a reduced-fat diet and a monoene-enriched diet in subjects with elevated serum cholesterol and triglyceride concentrations .
11690699	0	cholesterol	83,94	Insulin	0,7	cholesterol	Insulin	MESH:D002784	3630	Chemical	Gene	index|compound|START_ENTITY changing|dobj|index enhance|advcl|changing enhance|nsubj|injections injections|compound|END_ENTITY	Insulin injections enhance cholesterol_gallstone incidence by changing the biliary cholesterol saturation index and apo_A-I concentration in hamsters fed a lithogenic diet .
14657199	0	cholesterol	48,59	Insulin	0,7	cholesterol	Insulin	MESH:D002784	3630	Chemical	Gene	synthesis|compound|START_ENTITY associated|nmod|synthesis associated|nsubjpass|resistance resistance|compound|END_ENTITY	Insulin resistance is associated with increased cholesterol synthesis and decreased cholesterol absorption in normoglycemic men .
20356594	0	cholesterol	48,59	Insulin	0,7	cholesterol	Insulin	MESH:D002784	3630	Chemical	Gene	synthesis|compound|START_ENTITY associated|nmod|synthesis associated|nsubjpass|resistance resistance|compound|END_ENTITY	Insulin resistance is associated with increased cholesterol synthesis , decreased cholesterol absorption and enhanced lipid response to statin therapy .
20733269	0	cholesterol	32,43	Insulin	0,7	cholesterol	Insulin	MESH:D002784	3630	Chemical	Gene	efflux|compound|START_ENTITY suppresses|dobj|efflux suppresses|nsubj|END_ENTITY	Insulin suppresses HDL-mediated cholesterol efflux from macrophages through inhibition of neutral_cholesteryl_ester_hydrolase and ATP-binding cassette transporter G1 expressions .
1874173	0	cholesterol	23,34	Interleukin-1	0,13	cholesterol	Interleukin-1	MESH:D002784	3552	Chemical	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Interleukin-1 inhibits cholesterol side-chain cleavage cytochrome_P450 expression in primary cultures of Leydig cells .
15904871	0	cholesterol	67,78	Interleukin-6	0,13	cholesterol	Interleukin-6	MESH:D002784	3569	Chemical	Gene	responses|compound|START_ENTITY associated|nmod|responses associated|nsubjpass|genotype genotype|amod|END_ENTITY	Interleukin-6 genotype is associated with high-density lipoprotein cholesterol responses to exercise training .
16137286	0	cholesterol	31,42	Interleukin-6	0,13	cholesterol	Interleukin-6	MESH:D002784	3569	Chemical	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	Interleukin-6 modulates plasma cholesterol and C-reactive_protein concentrations in nonagenarians .
17374166	0	cholesterol	44,55	Interleukin-6	4,17	cholesterol	Interleukin-6	MESH:D002784	3569	Chemical	Gene	inflammation|nmod|START_ENTITY END_ENTITY|acl|inflammation	The Interleukin-6 inflammation pathway from cholesterol to aging -- role of statins , bisphosphonates and plant polyphenols in aging and age-related diseases .
21757719	0	cholesterol	55,66	Interleukin-6	0,13	cholesterol	Interleukin-6	MESH:D002784	3569	Chemical	Gene	accumulation|compound|START_ENTITY protects|nmod|accumulation protects|nsubj|END_ENTITY	Interleukin-6 protects human macrophages from cellular cholesterol accumulation and attenuates the proinflammatory response .
22216121	0	cholesterol	78,89	KIF6	9,13	cholesterol	KIF6	MESH:D002784	221458	Chemical	Gene	vulnerability|nmod|START_ENTITY vulnerability|compound|END_ENTITY	A common KIF6 polymorphism increases vulnerability to low-density lipoprotein cholesterol : two meta-analyses and a meta-regression analysis .
15121881	0	cholesterol	10,21	LAMP-2	72,78	cholesterol	LAMP-2	MESH:D002784	16784(Tax:10090)	Chemical	Gene	traffic|compound|START_ENTITY traffic|parataxis|fibroblasts fibroblasts|nsubj|double-deficient double-deficient|compound|END_ENTITY	Disturbed cholesterol traffic but normal proteolytic function in LAMP-1 / LAMP-2 double-deficient fibroblasts .
19929948	0	cholesterol	29,40	LAMP-2	9,15	cholesterol	LAMP-2	MESH:D002784	3920	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|nmod|transport	Role for LAMP-2 in endosomal cholesterol transport .
22090275	0	cholesterol	98,109	LCAT	0,4	cholesterol	LCAT	MESH:D002784	3931	Chemical	Gene	study|nmod|START_ENTITY END_ENTITY|dep|study	LCAT , HDL cholesterol and ischemic_cardiovascular_disease : a Mendelian randomization study of HDL cholesterol in 54,500 individuals .
22562159	0	cholesterol	5,16	LCAT	0,4	cholesterol	LCAT	MESH:D002784	100008978(Tax:9986)	Chemical	Gene	esterification|compound|START_ENTITY esterification|amod|END_ENTITY	LCAT cholesterol esterification is associated with the increase of ApoE/ApoA-I ratio during atherosclerosis progression in rabbit .
25964513	0	cholesterol	17,28	LCAT	47,51	cholesterol	LCAT	MESH:D002784	16816(Tax:10090)	Chemical	Gene	esterification|compound|START_ENTITY esterification|nmod|END_ENTITY	Increased plasma cholesterol esterification by LCAT reduces diet-induced atherosclerosis in SR-BI knockout mice .
17996658	0	cholesterol	24,35	LDL-C	37,42	cholesterol	LDL-C	MESH:D002784	22796	Chemical	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Low-density lipoprotein cholesterol -LRB- LDL-C -RRB- levels and LDL-C goal attainment among elderly patients treated with rosuvastatin compared with other statins in routine clinical practice .
8068598	0	cholesterol	50,61	LDL-C	63,68	cholesterol	LDL-C	MESH:D002784	22796	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Cyclosporin_A has divergent effects on plasma LDL cholesterol -LRB- LDL-C -RRB- and lipoprotein -LRB- a -RRB- -LSB- Lp -LRB- a -RRB- -RSB- levels in renal transplant recipients .
1981179	0	cholesterol	79,90	LDL-receptor	43,55	cholesterol	LDL-receptor	MESH:D002784	3949	Chemical	Gene	levels|compound|START_ENTITY gene|nmod|levels gene|amod|END_ENTITY	Association of DNA-haplotypes in the human LDL-receptor gene with normal serum cholesterol levels .
20959675	0	cholesterol	96,107	LDL-receptor	71,83	cholesterol	LDL-receptor	MESH:D002784	3949	Chemical	Gene	reduces|dobj|START_ENTITY reduces|nsubj|antibody antibody|acl:relcl|mimics mimics|dobj|domain domain|nmod|END_ENTITY	A PCSK9-binding antibody that structurally mimics the EGF -LRB- A -RRB- domain of LDL-receptor reduces LDL cholesterol in vivo .
24401224	0	cholesterol	102,113	LDL-receptor	123,135	cholesterol	LDL-receptor	MESH:D002784	16835(Tax:10090)	Chemical	Gene	mice|compound|START_ENTITY mice|compound|END_ENTITY	CER-001 , a HDL-mimetic , stimulates the reverse lipid transport and atherosclerosis regression in high cholesterol diet-fed LDL-receptor deficient mice .
10341873	0	cholesterol	16,27	LDL_receptor	67,79	cholesterol	LDL receptor	MESH:D002784	100009086(Tax:9986)	Chemical	Gene	START_ENTITY|acl|lowering lowering|dobj|effect effect|nmod|gene gene|compound|END_ENTITY	Enhanced plasma cholesterol lowering effect of retrovirus-mediated LDL_receptor gene transfer to WHHL rabbit liver after improved surgical technique and stimulation of hepatocyte proliferation by combined partial liver resection and thymidine kinase -- ganciclovir treatment .
10712395	0	cholesterol	9,20	LDL_receptor	83,95	cholesterol	LDL receptor	MESH:D002784	16835(Tax:10090)	Chemical	Gene	accelerates|nsubj|START_ENTITY accelerates|dobj|development development|nmod|atherosclerosis atherosclerosis|nmod|END_ENTITY	Oxidized cholesterol in the diet accelerates the development of atherosclerosis in LDL_receptor - and apolipoprotein_E-deficient mice .
11058701	0	cholesterol	41,52	LDL_receptor	134,146	cholesterol	LDL receptor	MESH:D002784	3949	Chemical	Gene	metabolism|compound|START_ENTITY lifibrol|nmod|metabolism effects|nmod|lifibrol effects|dep|evidence evidence|nmod|stimulation stimulation|nmod|pathway pathway|compound|END_ENTITY	The effects of lifibrol -LRB- K12 .148 -RRB- on the cholesterol metabolism of cultured cells : evidence for sterol independent stimulation of the LDL_receptor pathway .
11137088	0	cholesterol	104,115	LDL_receptor	33,45	cholesterol	LDL receptor	MESH:D002784	16835(Tax:10090)	Chemical	Gene	levels|compound|START_ENTITY END_ENTITY|nmod|levels	Essential role for the -LRB- hepatic -RRB- LDL_receptor in macrophage apolipoprotein_E-induced reduction in serum cholesterol levels and atherosclerosis .
11369802	0	cholesterol	56,67	LDL_receptor	31,43	cholesterol	LDL receptor	MESH:D002784	16835(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	Effects of coexpression of the LDL_receptor and apoE on cholesterol metabolism and atherosclerosis in LDL_receptor-deficient mice .
12208466	0	cholesterol	20,31	LDL_receptor	98,110	cholesterol	LDL receptor	MESH:D002784	16835(Tax:10090)	Chemical	Gene	reduction|compound|START_ENTITY reduction|nmod|atherosclerosis atherosclerosis|nmod|mice mice|compound|END_ENTITY	Combined effects of cholesterol reduction and apolipoprotein_A-I expression on atherosclerosis in LDL_receptor deficient mice .
12442279	0	cholesterol	116,127	LDL_receptor	47,59	cholesterol	LDL receptor	MESH:D002784	3949	Chemical	Gene	levels|compound|START_ENTITY effect|nmod|levels allele|dep|effect allele|nmod|gene gene|compound|END_ENTITY	A double mutant -LSB- N543H +2393 del9 -RSB- allele in the LDL_receptor gene in familial_hypercholesterolemia : effect on plasma cholesterol levels and cardiovascular_disease .
12475897	0	cholesterol	80,91	LDL_receptor	95,107	cholesterol	LDL receptor	MESH:D002784	3949	Chemical	Gene	START_ENTITY|nmod|deficiency deficiency|compound|END_ENTITY	Pharmacological interference with intestinal bile_acid transport reduces plasma cholesterol in LDL_receptor / apoE deficiency .
14512370	0	cholesterol	17,28	LDL_receptor	101,113	cholesterol	LDL receptor	MESH:D002784	3949	Chemical	Gene	variation|compound|START_ENTITY Magnitude|nmod|variation determined|nsubjpass|Magnitude determined|nmod|locus locus|compound|END_ENTITY	Magnitude of HDL cholesterol variation after high-dose atorvastatin is genetically determined at the LDL_receptor locus in patients with homozygous familial_hypercholesterolemia .
16840797	0	cholesterol	27,38	LDL_receptor	55,67	cholesterol	LDL receptor	MESH:D002784	16835(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|diets diets|nmod|END_ENTITY	Addition of dietary fat to cholesterol in the diets of LDL_receptor knockout mice : effects on plasma insulin , lipoproteins , and atherosclerosis .
17293475	0	cholesterol	89,100	LDL_receptor	158,170	cholesterol	LDL receptor	MESH:D002784	16835(Tax:10090)	Chemical	Gene	redistribution|compound|START_ENTITY redistribution|nmod|mice mice|compound|END_ENTITY	Important role for bone marrow-derived cholesteryl_ester transfer protein in lipoprotein cholesterol redistribution and atherosclerotic_lesion development in LDL_receptor knockout mice .
18346984	0	cholesterol	61,72	LDL_receptor	76,88	cholesterol	LDL receptor	MESH:D002784	16835(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|compound|END_ENTITY	Decreased lipoprotein clearance is responsible for increased cholesterol in LDL_receptor knockout mice with streptozotocin-induced diabetes .
19520913	0	cholesterol	14,25	LDL_receptor	78,90	cholesterol	LDL receptor	MESH:D002784	16835(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY regulates|dobj|uptake regulates|nmod|ubiquitination ubiquitination|nmod|END_ENTITY	LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL_receptor .
20229095	0	cholesterol	71,82	LDL_receptor	98,110	cholesterol	LDL receptor	MESH:D002784	16835(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|END_ENTITY	Cholesterol efflux via ATP-binding_cassette_transporter_A1 -LRB- ABCA1 -RRB- and cholesterol uptake via the LDL_receptor influences cholesterol-induced impairment_of_beta cell function in mice .
21741939	0	cholesterol	58,69	LDL_receptor	82,94	cholesterol	LDL receptor	MESH:D002784	16835(Tax:10090)	Chemical	Gene	START_ENTITY|acl|lowering lowering|nmod|mice mice|compound|END_ENTITY	Stage-specific remodeling of atherosclerotic_lesions upon cholesterol lowering in LDL_receptor knockout mice .
22355094	0	cholesterol	48,59	LDL_receptor	81,93	cholesterol	LDL receptor	MESH:D002784	16835(Tax:10090)	Chemical	Gene	analogs|dobj|START_ENTITY analogs|nmod|induction induction|nmod|expression expression|compound|END_ENTITY	Modified methylenedioxyphenol analogs lower LDL cholesterol through induction of LDL_receptor expression .
23087171	0	cholesterol	47,58	LDL_receptor	78,90	cholesterol	LDL receptor	MESH:D002784	16835(Tax:10090)	Chemical	Gene	independent|compound|START_ENTITY independent|nmod|END_ENTITY	Thyroid hormone receptor agonists reduce serum cholesterol independent of the LDL_receptor .
24942393	0	cholesterol	29,40	LDL_receptor	66,78	cholesterol	LDL receptor	MESH:D002784	3949	Chemical	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Reducing elevated plasma LDL cholesterol : the central role of the LDL_receptor .
24972343	0	cholesterol	51,62	LDL_receptor	95,107	cholesterol	LDL receptor	MESH:D002784	3949	Chemical	Gene	START_ENTITY|nmod|up-regulation up-regulation|nmod|END_ENTITY	Lupin peptides lower low-density lipoprotein -LRB- LDL -RRB- cholesterol through an up-regulation of the LDL_receptor / sterol_regulatory_element_binding_protein_2 -LRB- SREBP2 -RRB- pathway at HepG2 cell line .
2552800	0	cholesterol	142,153	LDL_receptor	17,29	cholesterol	LDL receptor	MESH:D002784	3949	Chemical	Gene	treatment|nmod|START_ENTITY lowering|nsubj|treatment function|advcl|lowering function|nsubj|Normalization Normalization|nmod|END_ENTITY	Normalization of LDL_receptor function by lymphocytes of patients with heterozygous familial_hypercholesterolemia after treatment with plasma cholesterol lowering agents .
2574032	0	cholesterol	81,92	LDL_receptor	18,30	cholesterol	LDL receptor	MESH:D002784	101016912	Chemical	Gene	levels|nmod|START_ENTITY associated|nmod|levels associated|nsubj|Identification Identification|nmod|marker marker|compound|END_ENTITY	Identification of LDL_receptor gene marker associated with altered levels of LDL cholesterol and apolipoprotein B in baboons .
3782157	1	cholesterol	202,213	LDL_receptor	143,155	cholesterol	LDL receptor	MESH:D002784	3949	Chemical	Gene	concentration|compound|START_ENTITY correlated|nmod|concentration correlated|nsubjpass|content content|amod|END_ENTITY	LDL_receptor protein content is correlated with plasma LDL cholesterol concentration .
3914990	0	cholesterol	48,59	LDL_receptor	4,16	cholesterol	LDL receptor	MESH:D002784	3949	Chemical	Gene	metabolism|compound|START_ENTITY regulation|nmod|metabolism regulation|compound|END_ENTITY	The LDL_receptor and the regulation of cellular cholesterol metabolism .
3949765	8	cholesterol	1770,1781	LDL_receptor	1615,1627	cholesterol	LDL receptor	MESH:D002784	3949	Chemical	Gene	efflux|compound|START_ENTITY promote|dobj|efflux discs|acl:relcl|promote incubated|nmod|discs negated|advcl|incubated negated|nsubjpass|ability ability|acl|enhance enhance|dobj|down-regulation down-regulation|compound|END_ENTITY	The ability of 58-035 to enhance LDL_receptor down-regulation was negated when cells were simultaneously incubated with recombinant high density lipoprotein3 discs , which promote cellular cholesterol efflux .
4075823	0	cholesterol	77,88	LDL_receptor	4,16	cholesterol	LDL receptor	MESH:D002784	3949	Chemical	Gene	homeostasis|compound|START_ENTITY regulate|dobj|homeostasis molecules|acl:relcl|regulate END_ENTITY|dep|molecules	The LDL_receptor and HMG-CoA_reductase -- two membrane molecules that regulate cholesterol homeostasis .
6397553	0	cholesterol	113,124	LDL_receptor	30,42	cholesterol	LDL receptor	MESH:D002784	3949	Chemical	Gene	regulate|dobj|START_ENTITY proteins|acl:relcl|regulate END_ENTITY|appos|proteins	Progress in understanding the LDL_receptor and HMG-CoA_reductase , two membrane proteins that regulate the plasma cholesterol .
7759150	0	cholesterol	91,102	LDL_receptor	10,22	cholesterol	LDL receptor	MESH:D002784	3949	Chemical	Gene	levels|compound|START_ENTITY rise|nmod|levels correlated|nmod|rise correlated|nsubjpass|expression expression|compound|END_ENTITY	Increased LDL_receptor mRNA expression in colon_cancer is correlated with a rise in plasma cholesterol levels after curative surgery .
7848617	0	cholesterol	104,115	LDL_receptor	25,37	cholesterol	LDL receptor	MESH:D002784	3949	Chemical	Gene	monkeys|compound|START_ENTITY Up-regulation|nmod|monkeys Up-regulation|nmod|expression expression|compound|END_ENTITY	Up-regulation of hepatic LDL_receptor gene expression by monatepil , a novel calcium antagonist , in high cholesterol diet-fed Japanese monkeys .
8148358	1	cholesterol	104,115	LDL_receptor	135,147	cholesterol	LDL receptor	MESH:D002784	100009086(Tax:9986)	Chemical	Gene	START_ENTITY|nmod|changes changes|nmod|mRNA mRNA|compound|END_ENTITY	Marked changes in LDL cholesterol without changes in LDL_receptor mRNA abundance .
8172843	0	cholesterol	82,93	LDL_receptor	44,56	cholesterol	LDL receptor	MESH:D002784	3949	Chemical	Gene	levels|compound|START_ENTITY affecting|dobj|levels Role|acl|affecting Role|nmod|gene gene|compound|END_ENTITY	Role of common genetic polymorphisms in the LDL_receptor gene in affecting plasma cholesterol levels in the general population .
8218105	0	cholesterol	37,48	LDL_receptor	68,80	cholesterol	LDL receptor	MESH:D002784	102127361	Chemical	Gene	independent|compound|START_ENTITY independent|nmod|END_ENTITY	Oral contraceptives decrease hepatic cholesterol independent of the LDL_receptor in nonhuman primates .
8489126	0	cholesterol	27,38	LDL_receptor	85,97	cholesterol	LDL receptor	MESH:D002784	3949	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|regulation regulation|nmod|activity activity|compound|END_ENTITY	The interaction of dietary cholesterol and specific_fatty_acids in the regulation of LDL_receptor activity and plasma LDL-cholesterol concentrations .
9168909	0	cholesterol	86,97	LDL_receptor	128,140	cholesterol	LDL receptor	MESH:D002784	16835(Tax:10090)	Chemical	Gene	synthesis|compound|START_ENTITY suppression|nmod|synthesis suppression|nmod|activity activity|compound|END_ENTITY	Hypocholesterolemic effect of lycopene and beta-carotene is related to suppression of cholesterol synthesis and augmentation of LDL_receptor activity in macrophages .
9081690	0	cholesterol	63,74	LDL_receptors	27,40	cholesterol	LDL receptors	MESH:D002784	16835(Tax:10090)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of leukocyte-specific LDL_receptors on plasma lipoprotein cholesterol and atherosclerosis in mice .
16263766	0	cholesterol	27,38	LPA1	99,103	cholesterol	LPA1	MESH:D002784	14745(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|endocytosis endocytosis|nmod|END_ENTITY	A requirement for membrane cholesterol in the beta-arrestin - and clathrin-dependent endocytosis of LPA1 lysophosphatidic_acid receptors .
19520913	0	cholesterol	14,25	LXR	0,3	cholesterol	LXR	MESH:D002784	22259(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY regulates|dobj|uptake regulates|nsubj|END_ENTITY	LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL_receptor .
19067122	0	cholesterol	32,43	LXR_alpha	73,82	cholesterol	LXR alpha	MESH:D002784	22259(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effects of high dietary fat and cholesterol on expression of PPAR_alpha , LXR_alpha , and their responsive genes in the liver of apoE and LDLR double deficient mice .
23313547	0	cholesterol	50,61	LXRa	37,41	cholesterol	LXRa	MESH:D002784	10062	Chemical	Gene	efflux|compound|START_ENTITY efflux|compound|END_ENTITY	Knock-down of the oxysterol receptor LXRa impairs cholesterol efflux in human primary macrophages : lack of compensation by LXRb activation .
8011684	0	cholesterol	21,32	Lactoferrin	0,11	cholesterol	Lactoferrin	MESH:D002784	280846(Tax:9913)	Chemical	Gene	accumulation|compound|START_ENTITY inhibits|dobj|accumulation inhibits|nsubj|END_ENTITY	Lactoferrin inhibits cholesterol accumulation in macrophages mediated by acetylated or oxidized low-density lipoproteins .
22729460	0	cholesterol	78,89	Liver_X_receptor	0,16	cholesterol	Liver X receptor	MESH:D002784	22260(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|dobj|transport	Liver_X_receptor b and peroxisome_proliferator-activated_receptor regulate cholesterol transport in murine cholangiocytes .
15280160	0	cholesterol	32,43	Liver_X_receptor-alpha	0,22	cholesterol	Liver X receptor-alpha	MESH:D002784	100352900(Tax:9986)	Chemical	Gene	efflux|compound|START_ENTITY mediates|dobj|efflux mediates|nsubj|END_ENTITY	Liver_X_receptor-alpha mediates cholesterol efflux in glomerular mesangial cells .
22461740	0	cholesterol	60,71	Low-density_lipoprotein_receptor	0,32	cholesterol	Low-density lipoprotein receptor	MESH:D002784	3949	Chemical	Gene	homeostasis|compound|START_ENTITY orchestrates|dobj|homeostasis orchestrates|nsubj|END_ENTITY	Low-density_lipoprotein_receptor -LRB- LDLR -RRB- family orchestrates cholesterol homeostasis .
9671018	0	cholesterol	64,75	Low-density_lipoprotein_receptor	0,32	cholesterol	Low-density lipoprotein receptor	MESH:D002784	3949	Chemical	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Low-density_lipoprotein_receptor genotype-dependent response to cholesterol lowering by combined pravastatin and cholestyramine in familial_hypercholesterolemia .
2297691	0	cholesterol	95,106	Low_density_lipoprotein_receptor	0,32	cholesterol	Low density lipoprotein receptor	MESH:D002784	3949	Chemical	Gene	requirement|compound|START_ENTITY activity|nmod|requirement activity|amod|END_ENTITY	Low_density_lipoprotein_receptor activity in human intracranial_tumors and its relation to the cholesterol requirement .
26617772	0	cholesterol	20,31	MCPIP	0,5	cholesterol	MCPIP	MESH:D002784	80149	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	MCPIP is induced by cholesterol and participated in cholesterol-caused DNA damage in HUVEC .
26806306	0	cholesterol	11,22	MD-2	0,4	cholesterol	MD-2	MESH:D002784	23643	Chemical	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	MD-2 binds cholesterol .
12070139	0	cholesterol	41,52	MLN64	0,5	cholesterol	MLN64	MESH:D002784	10948	Chemical	Gene	mobilization|nmod|START_ENTITY mediates|dobj|mobilization mediates|nsubj|END_ENTITY	MLN64 mediates mobilization of lysosomal cholesterol to steroidogenic mitochondria .
15205373	5	cholesterol	917,928	MLN64	973,978	cholesterol	MLN64	MESH:D002784	59045(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY transport|dep|metastatic_lymph_node_64 metastatic_lymph_node_64|appos|END_ENTITY	In the present study , the presence of StAR and for the first time , its homolog , the putative cholesterol transport protein metastatic_lymph_node_64 -LRB- MLN64 -RRB- , were defined in the neonatal mouse brain using immunocytochemical techniques .
16169523	0	cholesterol	108,119	MLN64	89,94	cholesterol	MLN64	MESH:D002784	10948	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|appos|transporter	BmStart1 , a novel carotenoid-binding_protein isoform from Bombyx_mori , is orthologous to MLN64 , a mammalian cholesterol transporter .
16709157	0	cholesterol	45,56	MLN64	0,5	cholesterol	MLN64	MESH:D002784	10948	Chemical	Gene	transport|compound|START_ENTITY mediators|nmod|transport END_ENTITY|appos|mediators	MLN64 and MENTHO , two mediators of endosomal cholesterol transport .
16990645	0	cholesterol	87,98	MLN64	47,52	cholesterol	MLN64	MESH:D002784	10948	Chemical	Gene	Modeling|nmod|START_ENTITY Modeling|dobj|structure structure|nmod|domains domains|nmod|proteins proteins|compound|END_ENTITY	Modeling the structure of the StART domains of MLN64 and StAR proteins in complex with cholesterol .
20511492	0	cholesterol	41,52	MLN64	23,28	cholesterol	MLN64	MESH:D002784	10948	Chemical	Gene	transport|compound|START_ENTITY function|nmod|transport function|csubj|STARTing STARTing|xcomp|understand understand|dobj|END_ENTITY	STARTing to understand MLN64 function in cholesterol transport .
23028046	0	cholesterol	66,77	MLN64	171,176	cholesterol	MLN64	MESH:D002784	59045(Tax:10090)	Chemical	Gene	enrichment|compound|START_ENTITY adaptation|nmod|enrichment adaptation|advcl|downregulating downregulating|dobj|END_ENTITY	Cellular adaptation to anthrax lethal toxin-induced mitochondrial cholesterol enrichment , hyperpolarization , and reactive oxygen species generation through downregulating MLN64 in macrophages .
21765216	0	cholesterol	59,70	MYLIP	10,15	cholesterol	MYLIP	MESH:D002784	29116	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|polymorphism polymorphism|compound|END_ENTITY	The N342S MYLIP polymorphism is associated with high total cholesterol and increased LDL_receptor degradation in humans .
25776636	0	cholesterol	23,34	MicroRNA-33a	0,12	cholesterol	MicroRNA-33a	MESH:D002784	407039	Chemical	Gene	synthesis|compound|START_ENTITY regulates|dobj|synthesis regulates|nsubj|END_ENTITY	MicroRNA-33a regulates cholesterol synthesis and cholesterol efflux related genes in osteoarthritic chondrocytes .
17956226	0	cholesterol	39,50	NPC1	11,15	cholesterol	NPC1	MESH:D002784	18145(Tax:10090)	Chemical	Gene	absorption|compound|START_ENTITY role|nmod|absorption role|nmod|END_ENTITY	A role for NPC1 and NPC2 in intestinal cholesterol absorption -- the hypothesis gutted .
24001314	0	cholesterol	29,40	NPC1	99,103	cholesterol	NPC1	MESH:D002784	4864	Chemical	Gene	transport|compound|START_ENTITY transport|dep|END_ENTITY	Computational studies of the cholesterol transport between NPC2 and the N-terminal domain of NPC1 -LRB- NPC1 -LRB- NTD -RRB- -RRB- .
15604518	0	cholesterol	8,19	NPC1L1	107,113	cholesterol	NPC1L1	MESH:D002784	237636(Tax:10090)	Chemical	Gene	absorption|compound|START_ENTITY coincides|dep|absorption coincides|nmod|expression expression|nmod|END_ENTITY	Reduced cholesterol absorption upon PPARdelta activation coincides with decreased intestinal expression of NPC1L1 .
16407187	0	cholesterol	83,94	NPC1L1	39,45	cholesterol	NPC1L1	MESH:D002784	29881	Chemical	Gene	uptake|compound|START_ENTITY facilitates|dobj|uptake facilitates|nsubj|translocation translocation|nmod|END_ENTITY	Cholesterol-regulated translocation of NPC1L1 to the cell surface facilitates free cholesterol uptake .
16829661	0	cholesterol	35,46	NPC1L1	25,31	cholesterol	NPC1L1	MESH:D002784	29881	Chemical	Gene	absorption|compound|START_ENTITY Localization|nmod|absorption Localization|nmod|END_ENTITY	Localization and role of NPC1L1 in cholesterol absorption in human intestine .
17523925	0	cholesterol	100,111	NPC1L1	0,6	cholesterol	NPC1L1	MESH:D002784	432367(Tax:10116)	Chemical	Gene	transport|nmod|START_ENTITY mediates|dobj|transport mediates|nsubj|END_ENTITY	NPC1L1 -LRB- Niemann-Pick_C1-like_1 -RRB- mediates sterol-specific unidirectional transport of non-esterified cholesterol in McArdle-RH7777 hepatoma cells .
17587760	0	cholesterol	74,85	NPC1L1	45,51	cholesterol	NPC1L1	MESH:D002784	29881	Chemical	Gene	absorption|compound|START_ENTITY reduce|dobj|absorption inhibition|acl|reduce inhibition|nmod|Niemann-Pick_C1 Niemann-Pick_C1|nmod|1 1|appos|END_ENTITY	Zetia : inhibition of Niemann-Pick_C1 Like 1 -LRB- NPC1L1 -RRB- to reduce intestinal cholesterol absorption and treat hyperlipidemia .
17689140	0	cholesterol	93,104	NPC1L1	43,49	cholesterol	NPC1L1	MESH:D002784	237636(Tax:10090)	Chemical	Gene	mediate|dep|START_ENTITY mediate|compound|END_ENTITY	Multiple plasma membrane receptors but not NPC1L1 mediate high-affinity , ezetimibe-sensitive cholesterol uptake into the intestinal brush border membrane .
17726195	0	cholesterol	31,42	NPC1L1	92,98	cholesterol	NPC1L1	MESH:D002784	237636(Tax:10090)	Chemical	Gene	absorption|compound|START_ENTITY absorption|nmod|modulation modulation|nmod|expression expression|nummod|END_ENTITY	Fenofibrate reduces intestinal cholesterol absorption via PPARalpha-dependent modulation of NPC1L1 expression in mouse .
18063367	0	cholesterol	73,84	NPC1L1	36,42	cholesterol	NPC1L1	MESH:D002784	29881	Chemical	Gene	absorption|compound|START_ENTITY inhibition|nmod|absorption ligands|nmod|inhibition ligands|nsubj|oxazolidinones oxazolidinones|nmod|END_ENTITY	Substituted oxazolidinones as novel NPC1L1 ligands for the inhibition of cholesterol absorption .
18373109	0	cholesterol	44,55	NPC1L1	0,6	cholesterol	NPC1L1	MESH:D002784	29881	Chemical	Gene	absorption|compound|START_ENTITY involved|nmod|absorption involved|nsubjpass|END_ENTITY	NPC1L1 and SR-BI are involved in intestinal cholesterol absorption from small-size lipid donors .
18522832	0	cholesterol	4,15	NPC1L1	102,108	cholesterol	NPC1L1	MESH:D002784	29881	Chemical	Gene	ezetimibe|compound|START_ENTITY acts|nsubj|ezetimibe acts|advcl|blocking blocking|dobj|internalization internalization|nmod|END_ENTITY	The cholesterol absorption inhibitor ezetimibe acts by blocking the sterol-induced internalization of NPC1L1 .
18718997	0	cholesterol	80,91	NPC1L1	22,28	cholesterol	NPC1L1	MESH:D002784	101840157	Chemical	Gene	prevents|nmod|START_ENTITY prevents|csubj|Inhibiting Inhibiting|dobj|activity activity|compound|END_ENTITY	Inhibiting intestinal NPC1L1 activity prevents diet-induced increase in biliary cholesterol in Golden Syrian_hamsters .
18850127	0	cholesterol	49,60	NPC1L1	35,41	cholesterol	NPC1L1	MESH:D002784	29881	Chemical	Gene	response|compound|START_ENTITY response|compound|END_ENTITY	Genetic variation in ABC G5/G8 and NPC1L1 impact cholesterol response to plant sterols in hypercholesterolemic men .
19141868	0	cholesterol	31,42	NPC1L1	68,74	cholesterol	NPC1L1	MESH:D002784	237636(Tax:10090)	Chemical	Gene	excretion|compound|START_ENTITY stimulation|nmod|excretion dependent|nsubj|stimulation dependent|advmod|END_ENTITY	Diosgenin stimulation of fecal cholesterol excretion in mice is not NPC1L1 dependent .
19325169	0	cholesterol	66,77	NPC1L1	27,33	cholesterol	NPC1L1	MESH:D002784	29881	Chemical	Gene	absorption|compound|START_ENTITY protein|nmod|absorption topology|appos|protein topology|nmod|END_ENTITY	Membrane topology of human NPC1L1 , a key protein in enterohepatic cholesterol absorption .
19443194	0	cholesterol	84,95	NPC1L1	115,121	cholesterol	NPC1L1	MESH:D002784	29881	Chemical	Gene	expression|nmod|START_ENTITY down-regulate|nmod|expression END_ENTITY|amod|down-regulate	Polyunsaturated_fatty_acids down-regulate in vitro expression of the key intestinal cholesterol absorption protein NPC1L1 : no effect of monounsaturated_nor_saturated_fatty_acids .
19823104	0	cholesterol	78,89	NPC1L1	59,65	cholesterol	NPC1L1	MESH:D002784	29881	Chemical	Gene	absorbers|compound|START_ENTITY observed|nmod|absorbers observed|nsubj|characterization characterization|nmod|variants variants|nmod|END_ENTITY	In-vitro characterization of the six clustered variants of NPC1L1 observed in cholesterol low absorbers .
20379057	0	cholesterol	24,35	NPC1L1	9,15	cholesterol	NPC1L1	MESH:D002784	29881	Chemical	Gene	absorption|compound|START_ENTITY affects|dobj|absorption affects|nsubj|SNP SNP|nmod|END_ENTITY	A SNP of NPC1L1 affects cholesterol absorption in Japanese .
20403165	0	cholesterol	18,29	NPC1L1	75,81	cholesterol	NPC1L1	MESH:D002784	29881	Chemical	Gene	uptake|compound|START_ENTITY inhibits|dobj|uptake inhibits|nmod|down-regulation down-regulation|nmod|expression expression|compound|END_ENTITY	Curcumin inhibits cholesterol uptake in Caco-2 cells by down-regulation of NPC1L1 expression .
20405839	0	cholesterol	9,20	NPC1L1	52,58	cholesterol	NPC1L1	MESH:D002784	29881	Chemical	Gene	up-regulates|compound|START_ENTITY intestinal|nsubj|up-regulates intestinal|dobj|END_ENTITY	Frequent cholesterol intake up-regulates intestinal NPC1L1 , ACAT2 , and MTP .
20809793	0	cholesterol	66,77	NPC1L1	24,30	cholesterol	NPC1L1	MESH:D002784	29881	Chemical	Gene	protein|nmod|START_ENTITY protein|appos|END_ENTITY	Niemann-pick_C1-like_1 -LRB- NPC1L1 -RRB- protein in intestinal and hepatic cholesterol transport .
21181463	0	cholesterol	41,52	NPC1L1	80,86	cholesterol	NPC1L1	MESH:D002784	29881	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Oleic_acid decreases the expression of a cholesterol transport-related protein -LRB- NPC1L1 -RRB- by the induction of endoplasmic reticulum stress in CaCo-2 cells .
21189420	0	cholesterol	66,77	NPC1L1	34,40	cholesterol	NPC1L1	MESH:D002784	237636(Tax:10090)	Chemical	Gene	absorbers|compound|START_ENTITY identified|nmod|absorbers identified|nsubj|characterization characterization|nmod|variants variants|nummod|END_ENTITY	Molecular characterization of the NPC1L1 variants identified from cholesterol low absorbers .
21561085	0	cholesterol	27,38	NPC1L1	72,78	cholesterol	NPC1L1	MESH:D002784	29881	Chemical	Gene	decreases|dobj|START_ENTITY decreases|nmod|down-regulation down-regulation|nmod|END_ENTITY	Microalga decreases plasma cholesterol by down-regulation of intestinal NPC1L1 , hepatic LDL_receptor , and HMG-CoA reductase .
21602275	0	cholesterol	46,57	NPC1L1	25,31	cholesterol	NPC1L1	MESH:D002784	237636(Tax:10090)	Chemical	Gene	binds|dobj|START_ENTITY binds|nsubj|domain domain|nmod|protein protein|compound|END_ENTITY	The N-terminal domain of NPC1L1 protein binds cholesterol and plays essential roles in cholesterol uptake .
24336247	0	cholesterol	47,58	NPC1L1	103,109	cholesterol	NPC1L1	MESH:D002784	237636(Tax:10090)	Chemical	Gene	absorption|compound|START_ENTITY regulates|dobj|absorption regulates|nmod|interaction interaction|nmod|END_ENTITY	The clathrin adaptor Numb regulates intestinal cholesterol absorption through dynamic interaction with NPC1L1 .
24904062	0	cholesterol	36,47	NPC1L1	84,90	cholesterol	NPC1L1	MESH:D002784	29881	Chemical	Gene	Niemann-Pick_C1-like_1|compound|START_ENTITY modulation|nmod|Niemann-Pick_C1-like_1 modulation|appos|END_ENTITY	Epigenetic modulation of intestinal cholesterol transporter Niemann-Pick_C1-like_1 -LRB- NPC1L1 -RRB- gene expression by DNA methylation .
25463095	0	cholesterol	77,88	NPC1L1	36,42	cholesterol	NPC1L1	MESH:D002784	237636(Tax:10090)	Chemical	Gene	determinant|nmod|START_ENTITY demonstration|nmod|determinant demonstration|nmod|END_ENTITY	Genetic demonstration of intestinal NPC1L1 as a major determinant of hepatic cholesterol and blood atherogenic lipoprotein levels .
25770315	0	cholesterol	71,82	NPC1L1	150,156	cholesterol	NPC1L1	MESH:D002784	29881	Chemical	Gene	allocation|nmod|START_ENTITY Effect|nmod|allocation mediated|nsubj|Effect mediated|nmod|polymorphisms polymorphisms|nmod|HMGCR HMGCR|compound|END_ENTITY	Effect of naturally random allocation to lower low-density lipoprotein cholesterol on the risk of coronary_heart_disease mediated by polymorphisms in NPC1L1 , HMGCR , or both : a 2 * 2 factorial Mendelian randomization study .
25841872	0	cholesterol	25,36	NPC1L1	49,55	cholesterol	NPC1L1	MESH:D002784	29881	Chemical	Gene	variation|nmod|START_ENTITY transporter|nsubj|variation transporter|dobj|END_ENTITY	Genetic variation in the cholesterol transporter NPC1L1 , ischaemic_vascular_disease , and gallstone_disease .
26048312	0	cholesterol	16,27	NPC1L1	77,83	cholesterol	NPC1L1	MESH:D002784	29881	Chemical	Gene	absorption|compound|START_ENTITY absorption|nmod|inhibition inhibition|appos|END_ENTITY	Orlistat limits cholesterol intestinal absorption by Niemann-pick_C1-like_1 -LRB- NPC1L1 -RRB- inhibition .
27075173	0	cholesterol	20,31	NPC1L1	42,48	cholesterol	NPC1L1	MESH:D002784	29881	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|protein protein|compound|END_ENTITY	Ezetimibe-sensitive cholesterol uptake by NPC1L1 protein does not require endocytosis .
21315718	0	cholesterol	23,34	NPC2	0,4	cholesterol	NPC2	MESH:D002784	67963(Tax:10090)	Chemical	Gene	secretion|compound|START_ENTITY regulates|dobj|secretion regulates|nsubj|END_ENTITY	NPC2 regulates biliary cholesterol secretion via stimulation of ABCG5/G8-mediated cholesterol transport .
24001314	0	cholesterol	29,40	NPC2	59,63	cholesterol	NPC2	MESH:D002784	10577	Chemical	Gene	transport|compound|START_ENTITY transport|nmod|END_ENTITY	Computational studies of the cholesterol transport between NPC2 and the N-terminal domain of NPC1 -LRB- NPC1 -LRB- NTD -RRB- -RRB- .
15127948	0	cholesterol	54,65	NT2	70,73	cholesterol	NT2	MESH:D002784	74120(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	Beta-lactotensin and neurotensin rapidly reduce serum cholesterol via NT2 receptor .
6169120	0	cholesterol	60,71	Neurotensin	0,11	cholesterol	Neurotensin	MESH:D002784	299757(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY effects|nmod|levels P|dep|effects P|compound|END_ENTITY	Neurotensin and substance P : differential effects on plasma cholesterol levels in conscious ovariectomized rats .
22585185	0	cholesterol	62,73	Niemann-Pick_C1	32,47	cholesterol	Niemann-Pick C1	MESH:D002784	18145(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY transport|compound|END_ENTITY	The role of decreased levels of Niemann-Pick_C1 intracellular cholesterol transport on obesity is reversed in the C57BL/6J , metabolic_syndrome mouse_strain : a metabolic or an inflammatory effect ?
20715096	0	cholesterol	33,44	Niemann-Pick_C1_like_1	78,100	cholesterol	Niemann-Pick C1 like 1	MESH:D002784	29881	Chemical	Gene	START_ENTITY|nmod|protein protein|amod|END_ENTITY	Dietary calcium decreases plasma cholesterol by down-regulation of intestinal Niemann-Pick_C1_like_1 and microsomal triacylglycerol transport protein and up-regulation of CYP7A1 and ABCG_5 / 8 in hamsters .
19965586	0	cholesterol	25,36	Niemann-Pick_Type_C1	97,117	cholesterol	Niemann-Pick Type C1	MESH:D002784	100689424	Chemical	Gene	egress|nmod|START_ENTITY mediates|dobj|egress mediates|nmod|endosomes endosomes|nmod|mitochondria mitochondria|nmod|absence absence|nmod|protein protein|amod|END_ENTITY	MLN64 mediates egress of cholesterol from endosomes to mitochondria in the absence of functional Niemann-Pick_Type_C1 protein .
10660558	0	cholesterol	101,112	Niemann-Pick_type_C1	8,28	cholesterol	Niemann-Pick type C1	MESH:D002784	100689424	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|protein protein|compound|END_ENTITY	Role of Niemann-Pick_type_C1 protein in intracellular trafficking of low density lipoprotein-derived cholesterol .
11013265	0	cholesterol	33,44	Niemann-Pick_type_C1	48,68	cholesterol	Niemann-Pick type C1	MESH:D002784	4864	Chemical	Gene	synthesized|dobj|START_ENTITY synthesized|nmod|cells cells|compound|END_ENTITY	Fate of endogenously synthesized cholesterol in Niemann-Pick_type_C1 cells .
12297829	0	cholesterol	75,86	Niemann-Pick_type_C1	13,33	cholesterol	Niemann-Pick type C1	MESH:D002784	18145(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Relevance of Niemann-Pick_type_C1 protein expression in controlling plasma cholesterol and biliary lipid secretion in mice .
12611909	0	cholesterol	48,59	Niemann-Pick_type_C1	123,143	cholesterol	Niemann-Pick type C1	MESH:D002784	18145(Tax:10090)	Chemical	Gene	synthesized|dobj|START_ENTITY synthesized|nmod|mice mice|compound|END_ENTITY	Trafficking defects in endogenously synthesized cholesterol in fibroblasts , macrophages , hepatocytes , and glial cells from Niemann-Pick_type_C1 mice .
14703504	0	cholesterol	49,60	Niemann-Pick_type_C1	81,101	cholesterol	Niemann-Pick type C1	MESH:D002784	18145(Tax:10090)	Chemical	Gene	accumulation|compound|START_ENTITY accumulation|nmod|brain brain|compound|END_ENTITY	A novel cholesterol stain reveals early neuronal cholesterol accumulation in the Niemann-Pick_type_C1 mouse brain .
14703504	0	cholesterol	8,19	Niemann-Pick_type_C1	81,101	cholesterol	Niemann-Pick type C1	MESH:D002784	18145(Tax:10090)	Chemical	Gene	stain|compound|START_ENTITY reveals|nsubj|stain reveals|dobj|accumulation accumulation|nmod|brain brain|compound|END_ENTITY	A novel cholesterol stain reveals early neuronal cholesterol accumulation in the Niemann-Pick_type_C1 mouse brain .
15644330	0	cholesterol	8,19	Niemann-Pick_type_C1	34,54	cholesterol	Niemann-Pick type C1	MESH:D002784	18145(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|nmod|brains brains|compound|END_ENTITY	Altered cholesterol metabolism in Niemann-Pick_type_C1 mouse brains affects mitochondrial function .
20581737	0	cholesterol	46,57	Niemann-Pick_type_C1	98,118	cholesterol	Niemann-Pick type C1	MESH:D002784	18145(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY normalizes|dobj|metabolism normalizes|nmod|organ organ|nmod|mouse mouse|compound|END_ENTITY	Weekly cyclodextrin administration normalizes cholesterol metabolism in nearly every organ of the Niemann-Pick_type_C1 mouse and markedly prolongs life .
24747682	0	cholesterol	112,123	Niemann-Pick_type_C1	137,157	cholesterol	Niemann-Pick type C1	MESH:D002784	18145(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY metabolism|nmod|transporter metabolism|xcomp|END_ENTITY	Impact of the loss of caveolin-1 on lung mass and cholesterol metabolism in mice with and without the lysosomal cholesterol transporter , Niemann-Pick_type_C1 .
23258338	0	cholesterol	44,55	Niemann-Pick_type_C1_Like_1	13,40	cholesterol	Niemann-Pick type C1 Like 1	MESH:D002784	29881	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	-LSB- Progress of Niemann-Pick_type_C1_Like_1 on cholesterol metabolism -RSB- .
10964915	0	cholesterol	59,70	Niemann-pick_type_C1	0,20	cholesterol	Niemann-pick type C1	MESH:D002784	4864	Chemical	Gene	homeostasis|compound|START_ENTITY alters|dobj|homeostasis alters|nsubj|overexpression overexpression|amod|END_ENTITY	Niemann-pick_type_C1 -LRB- NPC1 -RRB- overexpression alters cellular cholesterol homeostasis .
18500759	0	cholesterol	37,48	Npc1	15,19	cholesterol	Npc1	MESH:D002784	18145(Tax:10090)	Chemical	Gene	reduces|dobj|START_ENTITY reduces|nsubj|END_ENTITY	Astrocyte-only Npc1 reduces neuronal cholesterol and triples life span of Npc1 - / - mice .
18500759	0	cholesterol	37,48	Npc1	74,78	cholesterol	Npc1	MESH:D002784	18145(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Astrocyte-only Npc1 reduces neuronal cholesterol and triples life span of Npc1 - / - mice .
16179600	0	cholesterol	67,78	Npc1l1	57,63	cholesterol	Npc1l1	MESH:D002784	237636(Tax:10090)	Chemical	Gene	absorption|compound|START_ENTITY END_ENTITY|nmod|absorption	Role of intestinal sterol transporters Abcg5 , Abcg8 , and Npc1l1 in cholesterol absorption in mice : gender and age effects .
24336247	0	cholesterol	47,58	Numb	21,25	cholesterol	Numb	MESH:D002784	18222(Tax:10090)	Chemical	Gene	absorption|compound|START_ENTITY regulates|dobj|absorption regulates|nsubj|END_ENTITY	The clathrin adaptor Numb regulates intestinal cholesterol absorption through dynamic interaction with NPC1L1 .
22470048	0	cholesterol	52,63	Nur77	28,33	cholesterol	Nur77	MESH:D002784	3164	Chemical	Gene	metabolism|compound|START_ENTITY regulates|dobj|metabolism regulates|nsubj|END_ENTITY	The orphan nuclear receptor Nur77 regulates hepatic cholesterol metabolism through the suppression of LDLR and HMGCR expression .
22906437	0	cholesterol	9,20	ORP10	0,5	cholesterol	ORP10	MESH:D002784	114884	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	ORP10 , a cholesterol binding protein associated with microtubules , regulates apolipoprotein_B-100 secretion .
11861666	0	cholesterol	65,76	ORP2	0,4	cholesterol	ORP2	MESH:D002784	9885	Chemical	Gene	metabolism|compound|START_ENTITY regulates|dobj|metabolism regulates|nsubj|END_ENTITY	ORP2 , a homolog of oxysterol_binding_protein , regulates cellular cholesterol metabolism .
15859942	0	cholesterol	76,87	ORP2	42,46	cholesterol	ORP2	MESH:D002784	9885	Chemical	Gene	metabolism|compound|START_ENTITY induces|nmod|metabolism induces|nsubj|Overexpression Overexpression|nmod|OSBP-related_protein_2 OSBP-related_protein_2|appos|END_ENTITY	Overexpression of OSBP-related_protein_2 -LRB- ORP2 -RRB- induces changes in cellular cholesterol metabolism and enhances endocytosis .
8071608	0	cholesterol	12,23	Ob1771	29,35	cholesterol	Ob1771	MESH:D002784	1018265(Tax:221109)	Chemical	Gene	START_ENTITY|nmod|cells cells|amod|END_ENTITY	Transfer of cholesterol from Ob1771 cells or LDL to reconstituted , defined high density lipoproteins .
18937371	0	cholesterol	23,34	Osh4	42,46	cholesterol	Osh4	MESH:D002784	855958(Tax:4932)	Chemical	Gene	START_ENTITY|nmod|protein protein|amod|END_ENTITY	Binding and release of cholesterol in the Osh4 protein of yeast .
19129476	0	cholesterol	56,67	Oxysterol_binding_protein-related_Protein_9	0,43	cholesterol	Oxysterol binding protein-related Protein 9	MESH:D002784	114883	Chemical	Gene	protein|compound|START_ENTITY protein|nsubj|END_ENTITY	Oxysterol_binding_protein-related_Protein_9 -LRB- ORP9 -RRB- is a cholesterol transfer protein that regulates Golgi structure and function .
10066752	0	cholesterol	86,97	P-glycoprotein	28,42	cholesterol	P-glycoprotein	MESH:D002784	5243	Chemical	Gene	esterification|nmod|START_ENTITY enhances|dobj|esterification enhances|nsubj|END_ENTITY	Multidrug resistance -LRB- MDR1 -RRB- P-glycoprotein enhances esterification of plasma membrane cholesterol .
10869171	0	cholesterol	11,22	P-glycoprotein	55,69	cholesterol	P-glycoprotein	MESH:D002784	5243	Chemical	Gene	cholesterol|compound|START_ENTITY cholesterol|nmod|localization localization|amod|END_ENTITY	Effects of cholesterol and enantiomeric cholesterol on P-glycoprotein localization and function in low-density membrane domains .
10869171	0	cholesterol	40,51	P-glycoprotein	55,69	cholesterol	P-glycoprotein	MESH:D002784	5243	Chemical	Gene	START_ENTITY|nmod|localization localization|amod|END_ENTITY	Effects of cholesterol and enantiomeric cholesterol on P-glycoprotein localization and function in low-density membrane domains .
11718296	0	cholesterol	18,29	P-glycoprotein	48,62	cholesterol	P-glycoprotein	MESH:D002784	5243	Chemical	Gene	importance|nmod|START_ENTITY importance|nmod|activity activity|amod|END_ENTITY	The importance of cholesterol in maintenance of P-glycoprotein activity and its membrane perturbing influence .
12145328	0	cholesterol	61,72	P-glycoprotein	27,41	cholesterol	P-glycoprotein	MESH:D002784	5243	Chemical	Gene	redistribution|compound|START_ENTITY mediates|dobj|redistribution mediates|nsubj|transporter transporter|appos|END_ENTITY	The multidrug transporter , P-glycoprotein , actively mediates cholesterol redistribution in the cell membrane .
12586368	0	cholesterol	15,26	P-glycoprotein	85,99	cholesterol	P-glycoprotein	MESH:D002784	5243	Chemical	Gene	START_ENTITY|nmod|effect effect|nmod|dimethyl-beta-cyclodextrin dimethyl-beta-cyclodextrin|nmod|END_ENTITY	Involvement of cholesterol in the inhibitory effect of dimethyl-beta-cyclodextrin on P-glycoprotein and MRP2 function in Caco-2 cells .
15139519	0	cholesterol	16,27	P-glycoprotein	119,133	cholesterol	P-glycoprotein	MESH:D002784	5243	Chemical	Gene	Contribution|nmod|START_ENTITY Contribution|nmod|monolayers monolayers|amod|dimethyl-beta-cyclodextrin dimethyl-beta-cyclodextrin|nmod|function function|nmod|END_ENTITY	Contribution of cholesterol and phospholipids to inhibitory effect of dimethyl-beta-cyclodextrin on efflux function of P-glycoprotein and multidrug_resistance-associated_protein_2 in vinblastine-resistant Caco-2 cell monolayers .
15308763	0	cholesterol	23,34	P-glycoprotein	42,56	cholesterol	P-glycoprotein	MESH:D002784	5243	Chemical	Gene	Modulation|nmod|START_ENTITY alters|nsubj|Modulation alters|dobj|activity activity|amod|END_ENTITY	Modulation of cellular cholesterol alters P-glycoprotein activity in multidrug-resistant cells .
15766280	0	cholesterol	47,58	P-glycoprotein	11,25	cholesterol	P-glycoprotein	MESH:D002784	5243	Chemical	Gene	amounts|compound|START_ENTITY activity|nmod|amounts activity|amod|END_ENTITY	Control of P-glycoprotein activity by membrane cholesterol amounts and their relation to multidrug_resistance in human CEM_leukemia cells .
17497080	0	cholesterol	78,89	P-glycoprotein	0,14	cholesterol	P-glycoprotein	MESH:D002784	5243	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|dep|effects	P-glycoprotein in proteoliposomes with low residual detergent : the effects of cholesterol .
17653693	0	cholesterol	11,22	P-glycoprotein	40,54	cholesterol	P-glycoprotein	MESH:D002784	5243	Chemical	Gene	has|nsubj|START_ENTITY has|dobj|impact impact|nmod|activity activity|amod|END_ENTITY	Plasma LDL cholesterol has no impact on P-glycoprotein -LRB- MDR1/ABCB1 -RRB- activity in human peripheral blood mononuclear cells .
17923246	0	cholesterol	72,83	P-glycoprotein	0,14	cholesterol	P-glycoprotein	MESH:D002784	5243	Chemical	Gene	deprivation|compound|START_ENTITY downregulated|nmod|deprivation downregulated|nsubjpass|END_ENTITY	P-glycoprotein is downregulated in KG1a-primitive leukemia cells by LDL cholesterol deprivation and by HMG-CoA reductase inhibitors .
18539442	0	cholesterol	38,49	P-glycoprotein	0,14	cholesterol	P-glycoprotein	MESH:D002784	5243	Chemical	Gene	modulation|compound|START_ENTITY inhibition|nmod|modulation inhibition|nsubj|END_ENTITY	P-glycoprotein inhibition by membrane cholesterol modulation .
18547429	0	cholesterol	112,123	P-glycoprotein	64,78	cholesterol	P-glycoprotein	MESH:D002784	67078(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY implications|nmod|metabolism Effect|dep|implications Effect|nmod|mice mice|amod|fat fat|nmod|expression expression|nmod|deficient deficient|amod|END_ENTITY	Effect of dietary fat on hepatic liver_X_receptor expression in P-glycoprotein deficient mice : implications for cholesterol metabolism .
19049391	0	cholesterol	61,72	P-glycoprotein	19,33	cholesterol	P-glycoprotein	MESH:D002784	5243	Chemical	Gene	pump|nmod|START_ENTITY pump|amod|END_ENTITY	Interaction of the P-glycoprotein multidrug efflux pump with cholesterol : effects on ATPase activity , drug binding and transport .
23750858	0	cholesterol	99,110	P-glycoprotein	72,86	cholesterol	P-glycoprotein	MESH:D002784	67078(Tax:10090)	Chemical	Gene	Evaluation|nmod|START_ENTITY Evaluation|nmod|contribution contribution|nmod|transporter transporter|appos|END_ENTITY	Evaluation of the contribution of the ATP binding cassette transporter , P-glycoprotein , to in vivo cholesterol homeostasis .
26724201	0	cholesterol	88,99	P-glycoprotein	34,48	cholesterol	P-glycoprotein	MESH:D002784	5243	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|Understanding Understanding|dobj|accumulation accumulation|nmod|substrates substrates|amod|END_ENTITY	Understanding the accumulation of P-glycoprotein substrates within cells : The effect of cholesterol on membrane partitioning .
26311497	0	cholesterol	16,27	PAQR3	0,5	cholesterol	PAQR3	MESH:D002784	152559	Chemical	Gene	homeostasis|compound|START_ENTITY modulates|dobj|homeostasis modulates|nsubj|END_ENTITY	PAQR3 modulates cholesterol homeostasis by anchoring Scap/SREBP complex to the Golgi apparatus .
14727156	0	cholesterol	37,48	PCSK9	20,25	cholesterol	PCSK9	MESH:D002784	255738	Chemical	Gene	level|compound|START_ENTITY affect|dobj|level affect|nsubj|variants variants|nmod|END_ENTITY	Genetic variants in PCSK9 affect the cholesterol level in Japanese .
15654334	0	cholesterol	8,19	PCSK9	100,105	cholesterol	PCSK9	MESH:D002784	100102(Tax:10090)	Chemical	Gene	START_ENTITY|acl|resulting resulting|nmod|mutations mutations|nmod|END_ENTITY	Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9 .
15893176	0	cholesterol	149,160	PCSK9	9,14	cholesterol	PCSK9	MESH:D002784	255738	Chemical	Gene	levels|compound|START_ENTITY marker|nmod|levels marker|nsubj|haplotype haplotype|compound|END_ENTITY	A common PCSK9 haplotype , encompassing the E670G coding single nucleotide polymorphism , is a novel genetic marker for plasma low-density lipoprotein cholesterol levels and severity of coronary_atherosclerosis .
16465619	0	cholesterol	84,95	PCSK9	14,19	cholesterol	PCSK9	MESH:D002784	255738	Chemical	Gene	levels|nmod|START_ENTITY contributes|nmod|levels contributes|nsubj|spectrum spectrum|nmod|alleles alleles|nummod|END_ENTITY	A spectrum of PCSK9 alleles contributes to plasma levels of low-density lipoprotein cholesterol .
17170371	0	cholesterol	106,117	PCSK9	37,42	cholesterol	PCSK9	MESH:D002784	255738	Chemical	Gene	loss|nmod|START_ENTITY loss|nmod|gene gene|nummod|END_ENTITY	A novel loss of function mutation of PCSK9 gene in white subjects with low-plasma low-density lipoprotein cholesterol .
17316651	0	cholesterol	129,140	PCSK9	20,25	cholesterol	PCSK9	MESH:D002784	255738	Chemical	Gene	levels|compound|START_ENTITY contribute|nmod|levels variants|parataxis|contribute variants|nmod|END_ENTITY	Genetic variants in PCSK9 in the Japanese population : rare genetic variants in PCSK9 might collectively contribute to plasma LDL cholesterol levels in the general population .
17316651	0	cholesterol	129,140	PCSK9	79,84	cholesterol	PCSK9	MESH:D002784	255738	Chemical	Gene	levels|compound|START_ENTITY contribute|nmod|levels contribute|nsubj|variants variants|nmod|END_ENTITY	Genetic variants in PCSK9 in the Japanese population : rare genetic variants in PCSK9 might collectively contribute to plasma LDL cholesterol levels in the general population .
17502126	0	cholesterol	10,21	PCSK9	3,8	cholesterol	PCSK9	MESH:D002784	255738	Chemical	Gene	homeostasis|nsubj|START_ENTITY homeostasis|nmod|END_ENTITY	Of PCSK9 , cholesterol homeostasis and parasitic_infections : possible survival benefits of loss-of-function PCSK9 genetic polymorphisms .
17599443	0	cholesterol	61,72	PCSK9	12,17	cholesterol	PCSK9	MESH:D002784	255738	Chemical	Gene	serum|dobj|START_ENTITY mutations|acl|serum mutations|nsubj|Relation Relation|nmod|END_ENTITY	Relation of PCSK9 mutations to serum low-density lipoprotein cholesterol in childhood and adulthood -LRB- from The Bogalusa Heart Study -RRB- .
17645871	0	cholesterol	35,46	PCSK9	7,12	cholesterol	PCSK9	MESH:D002784	255738	Chemical	Gene	correlate|nmod|START_ENTITY correlate|nsubj|levels levels|compound|END_ENTITY	Plasma PCSK9 levels correlate with cholesterol in men but not in women .
18262190	0	cholesterol	79,90	PCSK9	25,30	cholesterol	PCSK9	MESH:D002784	255738	Chemical	Gene	levels|compound|START_ENTITY lowers|dobj|levels lowers|nsubj|variation variation|nmod|locus locus|nummod|END_ENTITY	Genetic variation at the PCSK9 locus moderately lowers low-density lipoprotein cholesterol levels , but does not significantly lower vascular_disease risk in an elderly population .
18343176	0	cholesterol	90,101	PCSK9	54,59	cholesterol	PCSK9	MESH:D002784	255738	Chemical	Gene	concentration|compound|START_ENTITY LDL|dobj|concentration LDL|nsubj|Effect Effect|nmod|subtilisin/kexin subtilisin/kexin|appos|END_ENTITY	Effect of protein convertase subtilisin/kexin type 9 -LRB- PCSK9 -RRB- 46L gene polymorphism on LDL cholesterol concentration in a Polish adult population .
18695239	0	cholesterol	55,66	PCSK9	27,32	cholesterol	PCSK9	MESH:D002784	255738	Chemical	Gene	lowers|dobj|START_ENTITY lowers|nsubj|END_ENTITY	Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL_cholesterol in nonhuman primates .
19075777	0	cholesterol	12,23	PCSK9	51,56	cholesterol	PCSK9	MESH:D002784	255738	Chemical	Gene	START_ENTITY|acl|lowering lowering|advcl|targeting targeting|dobj|END_ENTITY	Further LDL cholesterol lowering through targeting PCSK9 for coronary_artery_disease .
19191301	0	cholesterol	92,103	PCSK9	77,82	cholesterol	PCSK9	MESH:D002784	255738	Chemical	Gene	metabolism|compound|START_ENTITY gene|nmod|metabolism gene|compound|END_ENTITY	Mutations and polymorphisms in the proprotein convertase subtilisin kexin 9 -LRB- PCSK9 -RRB- gene in cholesterol metabolism and disease .
19191720	0	cholesterol	66,77	PCSK9	4,9	cholesterol	PCSK9	MESH:D002784	255738	Chemical	Gene	levels|compound|START_ENTITY affects|dobj|levels affects|nsubj|polymorphism polymorphism|compound|END_ENTITY	The PCSK9 gene E670G polymorphism affects low-density lipoprotein cholesterol levels but is not a risk factor for coronary_artery_disease in ethnic Chinese in Taiwan .
19917273	0	cholesterol	96,107	PCSK9	38,43	cholesterol	PCSK9	MESH:D002784	255738	Chemical	Gene	levels|nmod|START_ENTITY impact|nmod|levels has|dobj|impact has|nsubj|R46L R46L|nmod|gene gene|compound|END_ENTITY	Loss-of-function mutation R46L in the PCSK9 gene has little impact on the levels of total serum cholesterol in familial_hypercholesterolemia heterozygotes .
20031607	0	cholesterol	83,94	PCSK9	28,33	cholesterol	PCSK9	MESH:D002784	255738	Chemical	Gene	levels|compound|START_ENTITY variations|nmod|levels variations|nummod|END_ENTITY	Longitudinal association of PCSK9 sequence variations with low-density lipoprotein cholesterol levels : the Coronary Artery Risk Development in Young Adults Study .
20579540	0	cholesterol	36,47	PCSK9	0,5	cholesterol	PCSK9	MESH:D002784	255738	Chemical	Gene	levels|compound|START_ENTITY R46L|appos|levels R46L|compound|END_ENTITY	PCSK9 R46L , low-density lipoprotein cholesterol levels , and risk of ischemic_heart_disease : 3 independent studies and meta-analyses .
20623344	0	cholesterol	70,81	PCSK9	17,22	cholesterol	PCSK9	MESH:D002784	255738	Chemical	Gene	polymorphisms|nmod|START_ENTITY polymorphisms|nsubj|influence influence|nmod|END_ENTITY	The influence of PCSK9 polymorphisms on serum low-density lipoprotein cholesterol and risk of atherosclerosis .
20699424	0	cholesterol	48,59	PCSK9	11,16	cholesterol	PCSK9	MESH:D002784	255738	Chemical	Gene	levels|compound|START_ENTITY LDL|dobj|levels LDL|nsubj|Effects Effects|nmod|variants variants|nummod|END_ENTITY	Effects of PCSK9 genetic variants on plasma LDL cholesterol levels and risk of premature myocardial_infarction in the Italian population .
21813713	0	cholesterol	71,82	PCSK9	23,28	cholesterol	PCSK9	MESH:D002784	255738	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|variant variant|compound|END_ENTITY	Novel loss-of-function PCSK9 variant is associated with low plasma LDL cholesterol in a French-Canadian family and with impaired processing and secretion in cell culture .
22108858	0	cholesterol	71,82	PCSK9	0,5	cholesterol	PCSK9	MESH:D002784	255738	Chemical	Gene	reduction|nmod|START_ENTITY induce|dobj|reduction antisense|ccomp|induce antisense|nsubj|LNA LNA|compound|END_ENTITY	PCSK9 LNA antisense oligonucleotides induce sustained reduction of LDL cholesterol in nonhuman primates .
22294692	0	cholesterol	41,52	PCSK9	123,128	cholesterol	PCSK9	MESH:D002784	100102(Tax:10090)	Chemical	Gene	extending|dobj|START_ENTITY extending|advcl|lowering lowering|nmod|pH-sensitive pH-sensitive|nmod|END_ENTITY	Increasing serum half-life and extending cholesterol lowering in vivo by engineering antibody with pH-sensitive binding to PCSK9 .
22435370	0	cholesterol	48,59	PCSK9	35,40	cholesterol	PCSK9	MESH:D002784	255738	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|antibody antibody|nmod|END_ENTITY	Effect of a monoclonal antibody to PCSK9 on LDL cholesterol .
22519528	0	cholesterol	68,79	PCSK9	41,46	cholesterol	PCSK9	MESH:D002784	255738	Chemical	Gene	regulation|compound|START_ENTITY target|nmod|regulation Proprotein_convertase_subtilisin_kexin9|dep|target Proprotein_convertase_subtilisin_kexin9|appos|END_ENTITY	Proprotein_convertase_subtilisin_kexin9 -LRB- PCSK9 -RRB- : a novel target for cholesterol regulation .
22633824	0	cholesterol	95,106	PCSK9	35,40	cholesterol	PCSK9	MESH:D002784	255738	Chemical	Gene	reduce|dobj|START_ENTITY Effect|acl|reduce Effect|nmod|antibody antibody|nmod|REGN727/SAR236553 REGN727/SAR236553|compound|END_ENTITY	Effect of a monoclonal antibody to PCSK9 , REGN727/SAR236553 , to reduce low-density lipoprotein cholesterol in patients with heterozygous familial_hypercholesterolaemia on stable statin dose with or without ezetimibe therapy : a phase 2 randomised controlled trial .
22821907	0	cholesterol	49,60	PCSK9	14,19	cholesterol	PCSK9	MESH:D002784	255738	Chemical	Gene	way|nmod|START_ENTITY Antibodies|dep|way Antibodies|nmod|END_ENTITY	Antibodies to PCSK9 : a superior way to lower LDL cholesterol ?
23128163	0	cholesterol	68,79	PCSK9	35,40	cholesterol	PCSK9	MESH:D002784	255738	Chemical	Gene	levels|compound|START_ENTITY END_ENTITY|nmod|levels	Effect of a monoclonal antibody to PCSK9 on low-density lipoprotein cholesterol levels in statin-intolerant patients : the GAUSS randomized trial .
23300213	0	cholesterol	44,55	PCSK9	0,5	cholesterol	PCSK9	MESH:D002784	255738	Chemical	Gene	levels|compound|START_ENTITY associated|nmod|levels associated|nsubjpass|rs11591147 rs11591147|compound|END_ENTITY	PCSK9 SNP rs11591147 is associated with low cholesterol levels but not with cognitive performance or noncardiovascular clinical events in an elderly population .
23422832	0	cholesterol	34,45	PCSK9	0,5	cholesterol	PCSK9	MESH:D002784	255738	Chemical	Gene	homeostasis|compound|START_ENTITY role|nmod|homeostasis plays|dobj|role plays|nsubj|END_ENTITY	PCSK9 plays a significant role in cholesterol homeostasis and lipid transport in intestinal epithelial cells .
23422832	1	cholesterol	191,202	PCSK9	174,179	cholesterol	PCSK9	MESH:D002784	255738	Chemical	Gene	metabolism|compound|START_ENTITY regulates|dobj|metabolism regulates|nsubj|kexin_type_9 kexin_type_9|appos|END_ENTITY	OBJECTIVES : The proprotein_convertase_subtillisin / kexin_type_9 -LRB- PCSK9 -RRB- regulates cholesterol metabolism via degradation of low-density_lipoprotein_receptor -LRB- LDLr -RRB- .
23580231	0	cholesterol	32,43	PCSK9	60,65	cholesterol	PCSK9	MESH:D002784	100102(Tax:10090)	Chemical	Gene	lowers|dobj|START_ENTITY lowers|nmod|secretion secretion|compound|END_ENTITY	SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion .
24161333	0	cholesterol	162,173	PCSK9	272,277	cholesterol	PCSK9	MESH:D002784	255738	Chemical	Gene	goals|compound|START_ENTITY achievement|nmod|goals achievement|dep|assessment assessment|nmod|inhibition inhibition|compound|END_ENTITY	AMG 145 , a monoclonal antibody against PCSK9 , facilitates achievement of national cholesterol education program-adult treatment panel III low-density lipoprotein cholesterol goals among high-risk patients : an analysis from the LAPLACE-TIMI 57 trial -LRB- LDL-C assessment with PCSK9 monoclonal antibody inhibition combined with statin thErapy-thrombolysis in myocardial_infarction 57 -RRB- .
24161333	0	cholesterol	162,173	PCSK9	39,44	cholesterol	PCSK9	MESH:D002784	255738	Chemical	Gene	goals|compound|START_ENTITY achievement|nmod|goals facilitates|dobj|achievement facilitates|nsubj|AMG AMG|appos|antibody antibody|nmod|END_ENTITY	AMG 145 , a monoclonal antibody against PCSK9 , facilitates achievement of national cholesterol education program-adult treatment panel III low-density lipoprotein cholesterol goals among high-risk patients : an analysis from the LAPLACE-TIMI 57 trial -LRB- LDL-C assessment with PCSK9 monoclonal antibody inhibition combined with statin thErapy-thrombolysis in myocardial_infarction 57 -RRB- .
24161333	0	cholesterol	82,93	PCSK9	272,277	cholesterol	PCSK9	MESH:D002784	255738	Chemical	Gene	goals|compound|START_ENTITY achievement|nmod|goals achievement|dep|assessment assessment|nmod|inhibition inhibition|compound|END_ENTITY	AMG 145 , a monoclonal antibody against PCSK9 , facilitates achievement of national cholesterol education program-adult treatment panel III low-density lipoprotein cholesterol goals among high-risk patients : an analysis from the LAPLACE-TIMI 57 trial -LRB- LDL-C assessment with PCSK9 monoclonal antibody inhibition combined with statin thErapy-thrombolysis in myocardial_infarction 57 -RRB- .
24161333	0	cholesterol	82,93	PCSK9	39,44	cholesterol	PCSK9	MESH:D002784	255738	Chemical	Gene	goals|compound|START_ENTITY achievement|nmod|goals facilitates|dobj|achievement facilitates|nsubj|AMG AMG|appos|antibody antibody|nmod|END_ENTITY	AMG 145 , a monoclonal antibody against PCSK9 , facilitates achievement of national cholesterol education program-adult treatment panel III low-density lipoprotein cholesterol goals among high-risk patients : an analysis from the LAPLACE-TIMI 57 trial -LRB- LDL-C assessment with PCSK9 monoclonal antibody inhibition combined with statin thErapy-thrombolysis in myocardial_infarction 57 -RRB- .
24184943	0	cholesterol	24,35	PCSK9	63,68	cholesterol	PCSK9	MESH:D002784	255738	Chemical	Gene	reduction|compound|START_ENTITY reduction|nmod|END_ENTITY	Low-density lipoprotein cholesterol reduction by inhibition of PCSK9 .
24252255	0	cholesterol	62,73	PCSK9	45,50	cholesterol	PCSK9	MESH:D002784	255738	Chemical	Gene	levels|compound|START_ENTITY lowers|dobj|levels lowers|nsubj|antibody antibody|nmod|domain domain|nmod|END_ENTITY	An antibody against the C-terminal domain of PCSK9 lowers LDL cholesterol levels in vivo .
24701672	0	cholesterol	47,58	PCSK9	1,6	cholesterol	PCSK9	MESH:D002784	255738	Chemical	Gene	treatment|nmod|START_ENTITY inhibitors|dep|treatment inhibitors|nsubj|END_ENTITY	-LSB- PCSK9 inhibitors : emerging treatment to lower cholesterol ? -RSB- .
25046268	0	cholesterol	24,35	PCSK9	0,5	cholesterol	PCSK9	MESH:D002784	255738	Chemical	Gene	reduction|compound|START_ENTITY inhibition|nmod|reduction inhibition|nummod|END_ENTITY	PCSK9 inhibition in LDL cholesterol reduction : Genetics and therapeutic implications of very low plasma lipoprotein levels .
25134067	0	cholesterol	54,65	PCSK9	12,17	cholesterol	PCSK9	MESH:D002784	255738	Chemical	Gene	level|compound|START_ENTITY correlate|nmod|level correlate|nsubj|levels levels|compound|END_ENTITY	Circulating PCSK9 levels correlate with the serum LDL cholesterol level in newborn infants .
25244623	0	cholesterol	36,47	PCSK9	12,17	cholesterol	PCSK9	MESH:D002784	255738	Chemical	Gene	reduction|compound|START_ENTITY inhibitor|nmod|reduction inhibitor|nummod|END_ENTITY	Alirocumab : PCSK9 inhibitor for LDL cholesterol reduction .
25258384	0	cholesterol	58,69	PCSK9	0,5	cholesterol	PCSK9	MESH:D002784	100102(Tax:10090)	Chemical	Gene	circulating|dobj|START_ENTITY alter|advcl|circulating fails|xcomp|alter fails|nsubj|inhibition inhibition|compound|END_ENTITY	PCSK9 inhibition fails to alter hepatic LDLR , circulating cholesterol , and atherosclerosis in the absence of ApoE .
25770756	0	cholesterol	38,49	PCSK9	55,60	cholesterol	PCSK9	MESH:D002784	255738	Chemical	Gene	Association|nmod|START_ENTITY Association|nmod|levels levels|nummod|END_ENTITY	Association of plasma small dense LDL cholesterol with PCSK9 levels in patients with angiographically proven coronary_artery_disease .
26968977	0	cholesterol	181,192	PCSK9	16,21	cholesterol	PCSK9	MESH:D002784	255738	Chemical	Gene	referred|nmod|START_ENTITY referred|nsubj|Eligibility Eligibility|nmod|treatment treatment|nummod|END_ENTITY	Eligibility for PCSK9 treatment in 734 Hypercholesterolemic patients referred to a regional cholesterol treatment center with LDL_cholesterol > = 70 mg/dl despite maximal tolerated cholesterol lowering therapy .
26968977	0	cholesterol	92,103	PCSK9	16,21	cholesterol	PCSK9	MESH:D002784	255738	Chemical	Gene	center|compound|START_ENTITY referred|nmod|center referred|nsubj|Eligibility Eligibility|nmod|treatment treatment|nummod|END_ENTITY	Eligibility for PCSK9 treatment in 734 Hypercholesterolemic patients referred to a regional cholesterol treatment center with LDL_cholesterol > = 70 mg/dl despite maximal tolerated cholesterol lowering therapy .
8587457	3	cholesterol	577,588	PETN	641,645	cholesterol	ET-1	MESH:D002784	1906	Chemical	Gene	role|nmod|START_ENTITY END_ENTITY|nsubj|role	The objective of the present study was to investigate the effects of ergometric exercise on plasma ET-1 concentrations , and the potential modulatory role of LDL cholesterol , and the effects of an orally administered nitrate , PETN , in patients with CAD .
15604518	0	cholesterol	8,19	PPARdelta	36,45	cholesterol	PPARdelta	MESH:D002784	19015(Tax:10090)	Chemical	Gene	absorption|compound|START_ENTITY absorption|nmod|END_ENTITY	Reduced cholesterol absorption upon PPARdelta activation coincides with decreased intestinal expression of NPC1L1 .
12615696	7	cholesterol	1338,1349	PPARgamma	1259,1268	cholesterol	A1 and G1	MESH:D002784	109667;11629	Chemical	Gene	efflux|compound|START_ENTITY enhancing|dobj|efflux inhibited|advcl|enhancing inhibited|nsubj|END_ENTITY	This suggested that PPARgamma : RXR activation inhibited cholesteryl_ester accumulation by enhancing cholesterol efflux .
16007265	0	cholesterol	30,41	PPARgamma	0,9	cholesterol	PPARgamma	MESH:D002784	19016(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY regulates|dobj|metabolism regulates|nsubj|END_ENTITY	PPARgamma regulates adipocyte cholesterol metabolism via oxidized LDL receptor 1 .
17587765	0	cholesterol	21,32	PPARgamma	77,86	cholesterol	PPARgamma	MESH:D002784	5468	Chemical	Gene	efflux|compound|START_ENTITY enhances|dobj|efflux enhances|advcl|activating activating|dobj|END_ENTITY	Telmisartan enhances cholesterol efflux from THP-1 macrophages by activating PPARgamma .
19377069	0	cholesterol	14,25	PPARgamma	52,61	cholesterol	PPARgamma	MESH:D002784	19016(Tax:10090)	Chemical	Gene	efflux|compound|START_ENTITY associated|nsubjpass|efflux associated|nmod|activation activation|compound|END_ENTITY	CD36-mediated cholesterol efflux is associated with PPARgamma activation via a MAPK-dependent COX-2 pathway in macrophages .
20158087	0	cholesterol	93,104	PPARgamma	33,42	cholesterol	PPARgamma	MESH:D002784	5468	Chemical	Gene	-RSB-|compound|START_ENTITY activation|nmod|-RSB- effects|nmod|activation effects|nmod|END_ENTITY	-LSB- Anti-atherosclerotic effects by PPARgamma and its ligands through the activation of reverse cholesterol transport system -RSB- .
20170635	0	cholesterol	38,49	PPARgamma	0,9	cholesterol	PPARgamma	MESH:D002784	19016(Tax:10090)	Chemical	Gene	genes|compound|START_ENTITY expression|nmod|genes regulates|dobj|expression regulates|nsubj|END_ENTITY	PPARgamma regulates the expression of cholesterol metabolism genes in alveolar macrophages .
20177231	0	cholesterol	74,85	PTPN1	0,5	cholesterol	PTPN1	MESH:D002784	5770	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|polymorphisms polymorphisms|compound|END_ENTITY	PTPN1 polymorphisms are associated with total and low-density lipoprotein cholesterol .
22844422	0	cholesterol	54,65	PYY	19,22	cholesterol	PYY	MESH:D002784	5697	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Modulatory role of PYY in transport and metabolism of cholesterol in intestinal epithelial cells .
15805190	0	cholesterol	17,28	Pcsk9	77,82	cholesterol	Pcsk9	MESH:D002784	100102(Tax:10090)	Chemical	Gene	plasma|dobj|START_ENTITY plasma|nmod|mice mice|acl|lacking lacking|dobj|END_ENTITY	Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9 .
23883163	0	cholesterol	47,58	Pcsk9	100,105	cholesterol	Pcsk9	MESH:D002784	100102(Tax:10090)	Chemical	Gene	capacity|compound|START_ENTITY lacking|nsubj|capacity lacking|dobj|END_ENTITY	Decreased APOE-containing HDL subfractions and cholesterol efflux capacity of serum in mice lacking Pcsk9 .
23974119	0	cholesterol	88,99	Pcsk9	178,183	cholesterol	Pcsk9	MESH:D002784	100102(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY lipoprotein|dep|homeostasis regulate|iobj|lipoprotein regulate|dobj|END_ENTITY	FoxO3 transcription factor and Sirt6 deacetylase regulate low density lipoprotein -LRB- LDL -RRB- - cholesterol homeostasis via control of the proprotein_convertase_subtilisin / kexin_type_9 -LRB- Pcsk9 -RRB- gene expression .
9643351	0	cholesterol	69,80	Phospholipase_A2	0,16	cholesterol	Phospholipase A2	MESH:D002784	151056	Chemical	Gene	absorption|compound|START_ENTITY inhibition|nmod|absorption relieves|dobj|inhibition relieves|nsubj|END_ENTITY	Phospholipase_A2 relieves phosphatidylcholine inhibition of micellar cholesterol absorption and transport by human intestinal cell line Caco-2 .
25022542	0	cholesterol	31,42	Retnla	14,20	cholesterol	Retnla	MESH:D002784	57262(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY modulates|dobj|homeostasis modulates|nsubj|END_ENTITY	The adipokine Retnla modulates cholesterol homeostasis in hyperlipidemic mice .
25607353	0	cholesterol	44,55	Retnla	27,33	cholesterol	Retnla	MESH:D002784	57262(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY homeostasis|compound|END_ENTITY	Corrigendum : The adipokine Retnla modulates cholesterol homeostasis in hyperlipidemic mice .
15817453	0	cholesterol	134,145	RhoA	111,115	cholesterol	RhoA	MESH:D002784	387	Chemical	Gene	efflux|compound|START_ENTITY END_ENTITY|nmod|efflux	Regulation of macrophage cholesterol efflux through hydroxymethylglutaryl-CoA_reductase inhibition : a role for RhoA in ABCA1-mediated cholesterol efflux .
12472775	0	cholesterol	90,101	SR-B1	84,89	cholesterol	SR-B1	MESH:D002784	20778(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Sepsis_syndrome stimulates proximal tubule cholesterol synthesis and suppresses the SR-B1 cholesterol transporter .
12507911	0	cholesterol	50,61	SR-B1	63,68	cholesterol	SR-B1	MESH:D002784	949	Chemical	Gene	alters|dobj|START_ENTITY reductase|ccomp|alters reductase|nsubj|END_ENTITY	Experimental glomerulopathy alters renal cortical cholesterol , SR-B1 , ABCA1 , and HMG_CoA reductase expression .
18585981	7	cholesterol	1246,1257	SR-B1	1193,1198	cholesterol	SR-B1	MESH:D002784	20778(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY role|nmod|uptake play|dobj|role proposed|xcomp|play proposed|nsubjpass|END_ENTITY	SR-B1 has been proposed to play a role in intestinal cholesterol uptake , but in Npc1l1/SR-B 1 double null mice intestinal cholesterol absorption was not different than Npc1l1 null alone mice .
10064746	0	cholesterol	44,55	SR-BI	23,28	cholesterol	SR-BI	MESH:D002784	20778(Tax:10090)	Chemical	Gene	flux|compound|START_ENTITY mediates|dobj|flux mediates|nsubj|BI BI|appos|END_ENTITY	Scavenger receptor BI -LRB- SR-BI -RRB- mediates free cholesterol flux independently of HDL tethering to the cell surface .
10342834	2	cholesterol	378,389	SR-BI	279,284	cholesterol	SR-BI	MESH:D002784	25073(Tax:10116)	Chemical	Gene	delivery|nmod|START_ENTITY role|nmod|delivery plays|dobj|role indicating|ccomp|plays expressed|xcomp|indicating expressed|nsubjpass|END_ENTITY	SR-BI is expressed at high levels in the ovary , indicating that it plays a role in the delivery of cholesterol as substrate for steroid hormone production .
10787173	0	cholesterol	59,70	SR-BI	50,55	cholesterol	SR-BI	MESH:D002784	20778(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	The role of the high-density lipoprotein receptor SR-BI in cholesterol metabolism .
10872459	0	cholesterol	31,42	SR-BI	122,127	cholesterol	SR-BI	MESH:D002784	949	Chemical	Gene	fate|nmod|START_ENTITY Charting|dobj|fate Charting|parataxis|END_ENTITY	Charting the fate of the `` good cholesterol '' : identification and characterization of the high-density lipoprotein receptor SR-BI .
11882653	0	cholesterol	108,119	SR-BI	92,97	cholesterol	SR-BI	MESH:D002784	949	Chemical	Gene	efflux|compound|START_ENTITY I|dep|efflux I|appos|END_ENTITY	The effects of mutations in helices 4 and 6 of ApoA-I on scavenger receptor class B type I -LRB- SR-BI -RRB- - mediated cholesterol efflux suggest that formation of a productive complex between reconstituted high density lipoprotein and SR-BI is required for efficient lipid transport .
11923102	0	cholesterol	114,125	SR-BI	69,74	cholesterol	SR-BI	MESH:D002784	20778(Tax:10090)	Chemical	Gene	absorption|compound|START_ENTITY _|nmod|absorption _|dobj|type_I type_I|appos|END_ENTITY	The identification of intestinal scavenger_receptor_class_B , _ type_I -LRB- SR-BI -RRB- by expression cloning and its role in cholesterol absorption .
12117558	0	cholesterol	25,36	SR-BI	115,120	cholesterol	SR-BI	MESH:D002784	20778(Tax:10090)	Chemical	Gene	formation|compound|START_ENTITY Susceptibility|nmod|formation affected|nsubjpass|Susceptibility affected|nmod|disruption disruption|nmod|END_ENTITY	Susceptibility to murine cholesterol gallstone formation is not affected by partial disruption of the HDL receptor SR-BI .
12621157	3	cholesterol	593,604	SR-BI	678,683	cholesterol	SR-BI	MESH:D002784	100736552	Chemical	Gene	transport|compound|START_ENTITY affect|dobj|transport affect|xcomp|using using|dobj|cells cells|acl|overexpressing overexpressing|dobj|END_ENTITY	This study investigated whether AGE proteins serve as ligands for SR-BI and affect SR-BI-mediated cholesterol transport using Chinese_hamster ovary -LRB- CHO -RRB- cells overexpressing hamster SR-BI -LRB- CHO-SR-BI cells -RRB- .
12746305	2	cholesterol	465,476	SR-BI	533,538	cholesterol	SR-BI	MESH:D002784	949	Chemical	Gene	uptake|nmod|START_ENTITY mediated|nsubjpass|uptake mediated|nmod|type_I type_I|appos|END_ENTITY	The uptake of HDL-derived cholesterol is mediated by the scavenger_receptor , _ class_B , _ type_I -LRB- SR-BI -RRB- .
14528013	0	cholesterol	129,140	SR-BI	23,28	cholesterol	SR-BI	MESH:D002784	949	Chemical	Gene	trafficking|compound|START_ENTITY station|nmod|trafficking suggests|ccomp|station suggests|nsubj|Scavenger_receptor_BI Scavenger_receptor_BI|appos|END_ENTITY	Scavenger_receptor_BI -LRB- SR-BI -RRB- clustered on microvillar extensions suggests that this plasma membrane domain is a way station for cholesterol trafficking between cells and high-density lipoprotein .
14594995	0	cholesterol	89,100	SR-BI	63,68	cholesterol	SR-BI	MESH:D002784	949	Chemical	Gene	efflux|compound|START_ENTITY efflux|amod|END_ENTITY	In vivo modulation of HDL phospholipid has opposing effects on SR-BI - and ABCA1-mediated cholesterol efflux .
15910850	0	cholesterol	55,66	SR-BI	114,119	cholesterol	SR-BI	MESH:D002784	949	Chemical	Gene	levels|compound|START_ENTITY levels|nmod|polymorphisms polymorphisms|nmod|receptor receptor|appos|END_ENTITY	Modification of the effects of estrogen therapy on HDL cholesterol levels by polymorphisms of the HDL-C receptor , SR-BI : the Rancho Bernardo Study .
16185081	0	cholesterol	15,26	SR-BI	0,5	cholesterol	SR-BI	MESH:D002784	949	Chemical	Gene	efflux|compound|START_ENTITY mediates|dobj|efflux mediates|nsubj|END_ENTITY	SR-BI mediates cholesterol efflux via its interactions with lipid-bound ApoE .
16185081	1	cholesterol	117,128	SR-BI	102,107	cholesterol	SR-BI	MESH:D002784	949	Chemical	Gene	efflux|compound|START_ENTITY diminish|dobj|efflux diminish|nsubj|mutations mutations|nmod|END_ENTITY	Structural mutations in SR-BI diminish cholesterol efflux .
16200207	0	cholesterol	43,54	SR-BI	22,27	cholesterol	SR-BI	MESH:D002784	20778(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY drives|dobj|transport drives|nsubj|END_ENTITY	Shifting gears : liver SR-BI drives reverse cholesterol transport in macrophages .
16647293	0	cholesterol	102,113	SR-BI	75,80	cholesterol	SR-BI	MESH:D002784	20778(Tax:10090)	Chemical	Gene	efflux|compound|START_ENTITY efflux|amod|END_ENTITY	15-Lipoxygenase-mediated modification of high-density lipoproteins impairs SR-BI - and ABCA1-dependent cholesterol efflux from macrophages .
16794223	1	cholesterol	295,306	SR-BI	232,237	cholesterol	SR-BI	MESH:D002784	949	Chemical	Gene	transport|compound|START_ENTITY step|nmod|transport mediating|dobj|step plays|advcl|mediating plays|nsubj|I I|appos|END_ENTITY	OBJECTIVE : The high-density lipoprotein -LRB- HDL -RRB- receptor scavenger receptor Class B type I -LRB- SR-BI -RRB- plays a key role in mediating the final step of reverse cholesterol transport .
16861621	0	cholesterol	86,97	SR-BI	31,36	cholesterol	SR-BI	MESH:D002784	25073(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY associated|nmod|levels associated|nsubjpass|predominance predominance|nmod|one one|nmod|isoforms isoforms|amod|END_ENTITY	The predominance of one of the SR-BI isoforms is associated with increased esterified cholesterol levels not apoptosis in mink testis .
17030070	5	cholesterol	958,969	SR-BI	1057,1062	cholesterol	ABCA1	MESH:D002784	11303(Tax:10090)	Chemical	Gene	biosynthesis|compound|START_ENTITY required|nmod|biosynthesis enzymes|acl|required expression|nmod|enzymes regulate|dobj|expression concomitant|ccomp|regulate concomitant|parataxis|scavenger_receptor_class_B_type_I scavenger_receptor_class_B_type_I|appos|END_ENTITY	RESULTS : We found that CBS-deficiency in liver mice significantly increases expression of genes induced by endoplasmic reticulum stress and genes that regulate the expression of enzymes required for cholesterol and fatty_acid biosynthesis and uptake , notably the scavenger_receptor_class_B_type_I -LRB- SR-BI -RRB- , concomitant with overexpression of SR-BI at the protein level .
17372332	0	cholesterol	60,71	SR-BI	54,59	cholesterol	SR-BI	MESH:D002784	949	Chemical	Gene	transport|compound|START_ENTITY transport|amod|END_ENTITY	Effects of amino_acid substitutions at glycine 420 on SR-BI cholesterol transport function .
17960026	0	cholesterol	36,47	SR-BI	0,5	cholesterol	SR-BI	MESH:D002784	20778(Tax:10090)	Chemical	Gene	efflux|compound|START_ENTITY inhibits|dobj|efflux inhibits|nsubj|END_ENTITY	SR-BI inhibits ABCG1-stimulated net cholesterol efflux from cells to plasma HDL .
19252221	0	cholesterol	69,80	SR-BI	8,13	cholesterol	SR-BI	MESH:D002784	20778(Tax:10090)	Chemical	Gene	secretion|compound|START_ENTITY determines|dobj|secretion determines|nsubj|END_ENTITY	Hepatic SR-BI , not endothelial lipase , expression determines biliary cholesterol secretion in mice .
19304587	0	cholesterol	22,33	SR-BI	112,117	cholesterol	SR-BI	MESH:D002784	20778(Tax:10090)	Chemical	Gene	A1|compound|START_ENTITY A1|appos|END_ENTITY	Expression of reverse cholesterol transport proteins ATP-binding cassette A1 -LRB- ABCA1 -RRB- and scavenger_receptor_BI -LRB- SR-BI -RRB- in the retina and retinal pigment epithelium .
19815817	0	cholesterol	14,25	SR-BI	77,82	cholesterol	SR-BI	MESH:D002784	20778(Tax:10090)	Chemical	Gene	treated|nsubj|START_ENTITY treated|nmod|inhibitor inhibitor|compound|END_ENTITY	Increased HDL cholesterol and apoA-I in humans and mice treated with a novel SR-BI inhibitor .
20629037	0	cholesterol	53,64	SR-BI	0,5	cholesterol	SR-BI	MESH:D002784	20778(Tax:10090)	Chemical	Gene	efflux|compound|START_ENTITY contribute|nmod|efflux contribute|nsubj|END_ENTITY	SR-BI , CD36 , and caveolin-1 contribute positively to cholesterol efflux in hepatic cells .
20713650	0	cholesterol	83,94	SR-BI	106,111	cholesterol	SR-BI	MESH:D002784	949	Chemical	Gene	efflux|compound|START_ENTITY efflux|nmod|pathways pathways|compound|END_ENTITY	Postprandial_lipemia enhances the capacity of large HDL2 particles to mediate free cholesterol efflux via SR-BI and ABCG1 pathways in type_IIB_hyperlipidemia .
21289254	0	cholesterol	95,106	SR-BI	51,56	cholesterol	SR-BI	MESH:D002784	949	Chemical	Gene	efflux|compound|START_ENTITY efflux|nmod|END_ENTITY	Effect of bariatric surgery-induced weight_loss on SR-BI - , ABCG1 - , and ABCA1-mediated cellular cholesterol efflux in obese women .
21291868	0	cholesterol	38,49	SR-BI	108,113	cholesterol	SR-BI	MESH:D002784	20778(Tax:10090)	Chemical	Gene	macrophage|dobj|START_ENTITY macrophage|advcl|adipose adipose|nmod|mice mice|nmod|END_ENTITY	PPARy activation redirects macrophage cholesterol from fecal excretion to adipose tissue uptake in mice via SR-BI .
21454568	0	cholesterol	119,130	SR-BI	90,95	cholesterol	SR-BI	MESH:D002784	20778(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY attenuates|nmod|metabolism attenuates|dobj|effects effects|nmod|deficiency deficiency|amod|END_ENTITY	Cholesteryl_ester_transfer_protein expression partially attenuates the adverse effects of SR-BI receptor deficiency on cholesterol metabolism and atherosclerosis .
22589557	1	cholesterol	176,187	SR-BI	123,128	cholesterol	SR-BI	MESH:D002784	20778(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY role|nmod|transport plays|dobj|role plays|nsubj|Scavenger_receptor_BI Scavenger_receptor_BI|appos|END_ENTITY	Scavenger_receptor_BI -LRB- SR-BI -RRB- , an HDL receptor , plays a key role in reverse cholesterol transport .
22984960	0	cholesterol	56,67	SR-BI	0,5	cholesterol	SR-BI	MESH:D002784	100736552	Chemical	Gene	efflux|compound|START_ENTITY ABCG1-mediated|dobj|efflux ABCG1-mediated|nsubj|associates associates|amod|END_ENTITY	SR-BI associates with ABCG1 and inhibits ABCG1-mediated cholesterol efflux from cells to high-density lipoprotein 3 .
23197320	0	cholesterol	75,86	SR-BI	51,56	cholesterol	SR-BI	MESH:D002784	25073(Tax:10116)	Chemical	Gene	control|compound|START_ENTITY evade|dobj|control utilize|xcomp|evade utilize|dobj|END_ENTITY	Ovarian granulosa cells utilize scavenger receptor SR-BI to evade cellular cholesterol homeostatic control for steroid synthesis .
23410672	0	cholesterol	104,115	SR-BI	98,103	cholesterol	SR-BI	MESH:D002784	100009590(Tax:9986)	Chemical	Gene	efflux|compound|START_ENTITY efflux|amod|END_ENTITY	Fibrate treatment induced quantitative and qualitative HDL changes associated with an increase of SR-BI cholesterol efflux capacities in rabbits .
23564696	0	cholesterol	33,44	SR-BI	11,16	cholesterol	SR-BI	MESH:D002784	20778(Tax:10090)	Chemical	Gene	absorption|compound|START_ENTITY does|dobj|absorption does|nsubj|END_ENTITY	Intestinal SR-BI does not impact cholesterol absorption or transintestinal cholesterol efflux in mice .
24603680	10	cholesterol	1370,1381	SR-BI	1385,1390	cholesterol	SR-BI	MESH:D002784	20778(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|HDL HDL|compound|END_ENTITY	There was 3-fold enrichment of unesterified cholesterol in SR-BI -LRB- - / - -RRB- HDL compared with SR-BI -LRB- + / + -RRB- HDL .
25964513	0	cholesterol	17,28	SR-BI	92,97	cholesterol	SR-BI	MESH:D002784	20778(Tax:10090)	Chemical	Gene	esterification|compound|START_ENTITY reduces|nsubj|esterification reduces|dobj|atherosclerosis atherosclerosis|nmod|mice mice|amod|END_ENTITY	Increased plasma cholesterol esterification by LCAT reduces diet-induced atherosclerosis in SR-BI knockout mice .
8798380	0	cholesterol	149,160	SR-BI	23,28	cholesterol	SR-BI	MESH:D002784	20778(Tax:10090)	Chemical	Gene	stores|compound|START_ENTITY depletion|nmod|stores up-regulated|nmod|depletion up-regulated|nsubjpass|Scavenger_receptor_BI Scavenger_receptor_BI|appos|END_ENTITY	Scavenger_receptor_BI -LRB- SR-BI -RRB- is up-regulated in adrenal gland in apolipoprotein_A-I and hepatic_lipase knock-out mice as a response to depletion of cholesterol stores .
9391072	0	cholesterol	107,118	SR-BI	36,41	cholesterol	SR-BI	MESH:D002784	20778(Tax:10090)	Chemical	Gene	delivery|nmod|START_ENTITY route|nmod|delivery route|nsubj|type_I type_I|appos|END_ENTITY	Scavenger_receptor_class_B , _ type_I -LRB- SR-BI -RRB- is the major route for the delivery of high density lipoprotein cholesterol to the steroidogenic pathway in cultured mouse adrenocortical cells .
9539787	0	cholesterol	107,118	SR-BI	45,50	cholesterol	SR-BI	MESH:D002784	20778(Tax:10090)	Chemical	Gene	uptake|nmod|START_ENTITY reveals|nmod|uptake reveals|dobj|role role|nmod|END_ENTITY	Targeted mutation reveals a central role for SR-BI in hepatic selective uptake of high density lipoprotein cholesterol .
16788211	0	cholesterol	42,53	SREBP2	66,72	cholesterol	SREBP2	MESH:D002784	20788(Tax:10090)	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nmod|pathway pathway|compound|END_ENTITY	ABCA7 expression is regulated by cellular cholesterol through the SREBP2 pathway and associated with phagocytosis .
20732877	0	cholesterol	52,63	SREBP2	29,35	cholesterol	SREBP2	MESH:D002784	6721	Chemical	Gene	export|compound|START_ENTITY inhibits|dobj|export inhibits|nsubj|Expression Expression|nmod|miR-33 miR-33|nmod|intron intron|compound|END_ENTITY	Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty_acid oxidation .
23044239	0	cholesterol	83,94	SREBP2	38,44	cholesterol	SREBP2	MESH:D002784	6721	Chemical	Gene	accumulation|compound|START_ENTITY gene|nmod|accumulation gene|nummod|END_ENTITY	-LSB- Effect of RNAi-mediated silencing of SREBP2 gene on inflammatory cytokine-induced cholesterol accumulation in HepG2 cells -RSB- .
24249638	0	cholesterol	81,92	SREBP2	109,115	cholesterol	SREBP2	MESH:D002784	6721	Chemical	Gene	homeostasis|compound|START_ENTITY homeostasis|nmod|END_ENTITY	Amyloid_precursor_protein a - and b-cleaved ectodomains exert opposing control of cholesterol homeostasis via SREBP2 .
24465397	0	cholesterol	60,71	SREBP2	29,35	cholesterol	SREBP2	MESH:D002784	20788(Tax:10090)	Chemical	Gene	increases|dobj|START_ENTITY increases|nsubj|Overactivation Overactivation|nmod|END_ENTITY	Overactivation of intestinal SREBP2 in mice increases serum cholesterol .
24972343	0	cholesterol	51,62	SREBP2	153,159	cholesterol	SREBP2	MESH:D002784	6721	Chemical	Gene	lipoprotein|acl|START_ENTITY lipoprotein|dep|pathway pathway|appos|END_ENTITY	Lupin peptides lower low-density lipoprotein -LRB- LDL -RRB- cholesterol through an up-regulation of the LDL_receptor / sterol_regulatory_element_binding_protein_2 -LRB- SREBP2 -RRB- pathway at HepG2 cell line .
10342834	0	cholesterol	94,105	Scavenger_receptor_class_B_type_I	0,33	cholesterol	Scavenger receptor class B type I	MESH:D002784	25073(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY role|nmod|uptake END_ENTITY|dep|role	Scavenger_receptor_class_B_type_I in the rat ovary : possible role in high density lipoprotein cholesterol uptake and in the recognition of apoptotic granulosa cells .
11734569	0	cholesterol	42,53	Scavenger_receptor_class_B_type_I	0,33	cholesterol	Scavenger receptor class B type I	MESH:D002784	949	Chemical	Gene	homeostasis|compound|START_ENTITY affects|dobj|homeostasis affects|nsubj|END_ENTITY	Scavenger_receptor_class_B_type_I affects cholesterol homeostasis by magnifying cholesterol flux between cells and HDL .
11734569	0	cholesterol	80,91	Scavenger_receptor_class_B_type_I	0,33	cholesterol	Scavenger receptor class B type I	MESH:D002784	949	Chemical	Gene	flux|compound|START_ENTITY magnifying|dobj|flux affects|advcl|magnifying affects|nsubj|END_ENTITY	Scavenger_receptor_class_B_type_I affects cholesterol homeostasis by magnifying cholesterol flux between cells and HDL .
12736081	0	cholesterol	100,111	Scavenger_receptor_class_B_type_I	0,33	cholesterol	Scavenger receptor class B type I	MESH:D002784	20778(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|nsubj|END_ENTITY	Scavenger_receptor_class_B_type_I expression in murine brain and regulation by estrogen and dietary cholesterol .
14617739	0	cholesterol	42,53	Scavenger_receptor_class_B_type_I	0,33	cholesterol	Scavenger receptor class B type I	MESH:D002784	949	Chemical	Gene	absorption|compound|START_ENTITY reduces|dobj|absorption reduces|nsubj|END_ENTITY	Scavenger_receptor_class_B_type_I reduces cholesterol absorption in cultured enterocyte CaCo-2 cells .
23023567	0	cholesterol	55,66	Scavenger_receptor_class_B_type_I	0,33	cholesterol	Scavenger receptor class B type I	MESH:D002784	20778(Tax:10090)	Chemical	Gene	sensor|compound|START_ENTITY sensor|nsubj|END_ENTITY	Scavenger_receptor_class_B_type_I is a plasma membrane cholesterol sensor .
24060386	0	cholesterol	53,64	Scavenger_receptor_class_B_type_I	0,33	cholesterol	Scavenger receptor class B type I	MESH:D002784	949	Chemical	Gene	metabolism|compound|START_ENTITY regulates|dobj|metabolism regulates|nsubj|END_ENTITY	Scavenger_receptor_class_B_type_I regulates cellular cholesterol metabolism and cell signaling associated with breast_cancer development .
9488688	0	cholesterol	60,71	Scavenger_receptor_class_B_type_I	0,33	cholesterol	Scavenger receptor class B type I	MESH:D002784	949	Chemical	Gene	efflux|compound|START_ENTITY mediator|nmod|efflux END_ENTITY|nmod|mediator	Scavenger_receptor_class_B_type_I as a mediator of cellular cholesterol efflux to lipoproteins and phospholipid acceptors .
18979284	0	cholesterol	21,32	St2b2	51,56	cholesterol	St2b2	MESH:D002784	56362(Tax:10090)	Chemical	Gene	sulfotransferase|compound|START_ENTITY sulfotransferase|appos|END_ENTITY	Expression of a skin cholesterol sulfotransferase , St2b2 , is a trigger of epidermal cell differentiation .
10548884	0	cholesterol	99,110	StAR	44,48	cholesterol	StAR	MESH:D002784	6770	Chemical	Gene	trafficking|compound|START_ENTITY complexities|nmod|trafficking window|nmod|complexities protein|dep|window protein|appos|END_ENTITY	The steroidogenic_acute_regulatory protein -LRB- StAR -RRB- : a window into the complexities of intracellular cholesterol trafficking .
11196443	0	cholesterol	49,60	StAR	16,20	cholesterol	StAR	MESH:D002784	6770	Chemical	Gene	transfer|compound|START_ENTITY mitochondrial|dobj|transfer expression|xcomp|mitochondrial expression|nsubj|Relationship Relationship|nmod|END_ENTITY	Relationship of StAR expression to mitochondrial cholesterol transfer and metabolism .
11579102	0	cholesterol	122,133	StAR	86,90	cholesterol	StAR	MESH:D002784	6770	Chemical	Gene	transfer|compound|START_ENTITY mediates|dobj|transfer mediates|nsubj|processing processing|nmod|steroidogenic_acute_regulatory_protein steroidogenic_acute_regulatory_protein|appos|END_ENTITY	Mitochondrial processing of newly synthesized steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- , but not total StAR , mediates cholesterol transfer to cytochrome P450 side chain cleavage enzyme in adrenal cells .
12372832	0	cholesterol	12,23	StAR	110,114	cholesterol	StAR	MESH:D002784	6770	Chemical	Gene	Transfer|nmod|START_ENTITY mediated|nsubj|Transfer mediated|nmod|steroidogenic_acute_regulatory_protein steroidogenic_acute_regulatory_protein|appos|END_ENTITY	Transfer of cholesterol between phospholipid vesicles mediated by the steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- .
12459035	0	cholesterol	70,81	StAR	233,237	cholesterol	StAR	MESH:D002784	6770	Chemical	Gene	transfer|compound|START_ENTITY Insights|dep|transfer unfolded|nsubj|Insights unfolded|dobj|states states|nmod|END_ENTITY	Insights into steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- - dependent cholesterol transfer in mitochondria : evidence from molecular modeling and structure-based thermodynamics supporting the existence of partially unfolded states of StAR .
12459035	0	cholesterol	70,81	StAR	54,58	cholesterol	StAR	MESH:D002784	6770	Chemical	Gene	transfer|compound|START_ENTITY Insights|dep|transfer Insights|nmod|steroidogenic_acute_regulatory_protein steroidogenic_acute_regulatory_protein|appos|END_ENTITY	Insights into steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- - dependent cholesterol transfer in mitochondria : evidence from molecular modeling and structure-based thermodynamics supporting the existence of partially unfolded states of StAR .
15342684	0	cholesterol	39,50	StAR	65,69	cholesterol	StAR	MESH:D002784	25557(Tax:10116)	Chemical	Gene	transporters|compound|START_ENTITY transporters|dep|END_ENTITY	Effect of increasing the expression of cholesterol transporters -LRB- StAR , MLN64 , and SCP-2 -RRB- on bile_acid synthesis .
15713539	0	cholesterol	49,60	StAR	142,146	cholesterol	StAR	MESH:D002784	20845(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY increases|dobj|metabolism increases|nmod|increases increases|nmod|protein protein|appos|END_ENTITY	Novel signaling stimulated by arsenite increases cholesterol metabolism through increases in unphosphorylated steroidogenic acute regulatory -LRB- StAR -RRB- protein .
16303614	0	cholesterol	81,92	StAR	51,55	cholesterol	StAR	MESH:D002784	281507(Tax:9913)	Chemical	Gene	cleavage|compound|START_ENTITY cleavage|compound|END_ENTITY	Stimulatory effect of LH , PGE2 and progesterone on StAR protein , cytochrome P450 cholesterol side chain cleavage and 3beta hydroxysteroid dehydrogenase gene expression in bovine luteal cells .
16973755	0	cholesterol	102,113	StAR	0,4	cholesterol	StAR	MESH:D002784	6770	Chemical	Gene	import|compound|START_ENTITY mediates|dobj|import know|advcl|mediates END_ENTITY|acl:relcl|know	StAR search -- what we know about how the steroidogenic_acute_regulatory_protein mediates mitochondrial cholesterol import .
16973755	6	cholesterol	1241,1252	StAR	1163,1167	cholesterol	StAR	MESH:D002784	6770	Chemical	Gene	required|nmod|START_ENTITY undergoes|parataxis|required undergoes|dobj|change change|acl:relcl|opens opens|dobj|pocket pocket|nmod:poss|END_ENTITY	When StAR interacts with protonated phospholipid head groups on the outer mitochondrial membrane , it undergoes a conformational change -LRB- molten globule transition -RRB- that opens and closes StAR 's cholesterol-binding pocket ; this conformational change is required for cholesterol binding , which is required for StAR activity .
17207924	0	cholesterol	48,59	StAR	13,17	cholesterol	StAR	MESH:D002784	6770	Chemical	Gene	import|compound|START_ENTITY Mechanism|nmod|import Mechanism|nmod|regulation regulation|nmod:poss|END_ENTITY	Mechanism of StAR 's regulation of mitochondrial cholesterol import .
17433772	0	cholesterol	69,80	StAR	40,44	cholesterol	StAR	MESH:D002784	6770	Chemical	Gene	transporter|compound|START_ENTITY mitochondrial|dobj|transporter mitochondrial|dep|END_ENTITY	Steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- , a novel mitochondrial cholesterol transporter .
19095060	0	cholesterol	31,42	StAR	54,58	cholesterol	StAR	MESH:D002784	6770	Chemical	Gene	mechanism|nmod|START_ENTITY Validation|nmod|mechanism binding|nsubj|Validation binding|nmod|END_ENTITY	Validation of the mechanism of cholesterol binding by StAR using short molecular dynamics simulations .
7547998	0	cholesterol	105,116	StAR	63,67	cholesterol	StAR	MESH:D002784	6770	Chemical	Gene	activity|compound|START_ENTITY stimulates|dep|activity Structure|dep|stimulates Structure|nmod|gene gene|appos|END_ENTITY	Structure of the human steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- gene : StAR stimulates mitochondrial cholesterol 27-hydroxylase activity .
7547998	0	cholesterol	105,116	StAR	75,79	cholesterol	StAR	MESH:D002784	6770	Chemical	Gene	activity|compound|START_ENTITY stimulates|dep|activity stimulates|compound|END_ENTITY	Structure of the human steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- gene : StAR stimulates mitochondrial cholesterol 27-hydroxylase activity .
18403318	0	cholesterol	56,67	StarD4	38,44	cholesterol	StarD4	MESH:D002784	170459(Tax:10090)	Chemical	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Intracellular cholesterol transporter StarD4 binds free cholesterol and increases cholesteryl_ester formation .
15760897	0	cholesterol	50,61	StarD5	43,49	cholesterol	StarD5	MESH:D002784	170460(Tax:10090)	Chemical	Gene	proteins|compound|START_ENTITY proteins|amod|END_ENTITY	Differential gene regulation of StarD4 and StarD5 cholesterol transfer proteins .
16534142	0	cholesterol	23,34	StarD5	16,22	cholesterol	StarD5	MESH:D002784	80765	Chemical	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	Localization of StarD5 cholesterol binding protein .
14745013	0	cholesterol	39,50	Start1	20,26	cholesterol	Start1	MESH:D002784	37927(Tax:7227)	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|dep|transporter	The Drosophila gene Start1 : a putative cholesterol transporter and key regulator of ecdysteroid synthesis .
11489878	0	cholesterol	45,56	Steroidogenic_acute_regulatory_protein	0,38	cholesterol	Steroidogenic acute regulatory protein	MESH:D002784	6770	Chemical	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Steroidogenic_acute_regulatory_protein binds cholesterol and modulates mitochondrial membrane sterol domain dynamics .
10954705	0	cholesterol	66,77	Sterol_carrier_protein-2	0,24	cholesterol	Sterol carrier protein-2	MESH:D002784	6342	Chemical	Gene	efflux|compound|START_ENTITY density|dep|efflux alters|dobj|density alters|nsubj|END_ENTITY	Sterol_carrier_protein-2 alters high density lipoprotein-mediated cholesterol efflux .
12479573	0	cholesterol	39,50	Sterol_carrier_protein-2	0,24	cholesterol	Sterol carrier protein-2	MESH:D002784	6342	Chemical	Gene	just|nmod|START_ENTITY END_ENTITY|dep|just	Sterol_carrier_protein-2 : not just for cholesterol any more .
7642518	0	cholesterol	40,51	Sterol_carrier_protein-2	0,24	cholesterol	Sterol carrier protein-2	MESH:D002784	6342	Chemical	Gene	transfer|compound|START_ENTITY involved|nmod|transfer involved|nsubjpass|END_ENTITY	Sterol_carrier_protein-2 is involved in cholesterol transfer from the endoplasmic reticulum to the plasma membrane in human fibroblasts .
6466324	0	cholesterol	52,63	Sterol_carrier_protein2	0,23	cholesterol	Sterol carrier protein2	MESH:D002784	25541(Tax:10116)	Chemical	Gene	transfer|nmod|START_ENTITY END_ENTITY|dep|transfer	Sterol_carrier_protein2 -LRB- SCP2 -RRB- - mediated transfer of cholesterol to mitochondrial inner membranes .
21740188	0	cholesterol	67,78	TERE1	37,42	cholesterol	TERE1	MESH:D002784	29914	Chemical	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	The bladder_tumor suppressor protein TERE1 -LRB- UBIAD1 -RRB- modulates cell cholesterol : implications for tumor progression .
23759948	0	cholesterol	217,228	TERE1	26,31	cholesterol	TERE1	MESH:D002784	29914	Chemical	Gene	metabolism|compound|START_ENTITY involved|nmod|metabolism genes|acl|involved associated|nmod|genes phenotype|acl|associated growth|dep|phenotype inhibits|dobj|growth inhibits|nsubj|expression expression|nmod|protein protein|amod|END_ENTITY	Ectopic expression of the TERE1 -LRB- UBIAD1 -RRB- protein inhibits growth of renal_clear_cell_carcinoma cells : altered metabolic phenotype associated with reactive oxygen species , nitric_oxide and SXR target genes involved in cholesterol and lipid metabolism .
23919967	0	cholesterol	77,88	TERE1	21,26	cholesterol	TERE1	MESH:D002784	29914	Chemical	Gene	phenotype|compound|START_ENTITY regulates|dobj|phenotype regulates|nsubj|END_ENTITY	The tumor suppressor TERE1 -LRB- UBIAD1 -RRB- prenyltransferase regulates the elevated cholesterol phenotype in castration resistant prostate_cancer by controlling a program of ligand dependent SXR target genes .
11478905	0	cholesterol	28,39	THP-1	52,57	cholesterol	THP-1	MESH:D002784	2736	Chemical	Gene	efflux|compound|START_ENTITY evaluate|dobj|efflux evaluate|nmod|END_ENTITY	A kinetic model to evaluate cholesterol efflux from THP-1 macrophages to apolipoprotein A-1 .
14499733	0	cholesterol	132,143	THP-1	162,167	cholesterol	THP-1	MESH:D002784	2736	Chemical	Gene	efflux|compound|START_ENTITY decrease|nmod|efflux contributes|nmod|decrease contributes|nmod|macrophages macrophages|compound|END_ENTITY	HDL derived from the different phases of conjugated diene formation reduces membrane fluidity and contributes to a decrease in free cholesterol efflux from human THP-1 macrophages .
15136056	0	cholesterol	80,91	THP-1	107,112	cholesterol	THP-1	MESH:D002784	2736	Chemical	Gene	homeostasis|compound|START_ENTITY homeostasis|nmod|macrophages macrophages|compound|END_ENTITY	Conjugated linoleic_acid and atherosclerosis : no effect on molecular markers of cholesterol homeostasis in THP-1 macrophages .
15183127	0	cholesterol	27,38	THP-1	55,60	cholesterol	THP-1	MESH:D002784	2736	Chemical	Gene	accumulation|compound|START_ENTITY accumulation|nmod|END_ENTITY	Reduction of intracellular cholesterol accumulation in THP-1 macrophages by a combination of rosiglitazone and atorvastatin .
16019008	0	cholesterol	121,132	THP-1	151,156	cholesterol	THP-1	MESH:D002784	2736	Chemical	Gene	efflux|compound|START_ENTITY oxidation|dobj|efflux oxidation|nmod|macrophages macrophages|compound|END_ENTITY	Phenolic-extract from argan oil -LRB- Argania spinosa L. -RRB- inhibits human low-density lipoprotein -LRB- LDL -RRB- oxidation and enhances cholesterol efflux from human THP-1 macrophages .
17045616	0	cholesterol	81,92	THP-1	103,108	cholesterol	THP-1	MESH:D002784	2736	Chemical	Gene	efflux|compound|START_ENTITY efflux|nmod|macrophage macrophage|compound|END_ENTITY	Marrubium vulgare extract inhibits human-LDL oxidation and enhances HDL-mediated cholesterol efflux in THP-1 macrophage .
17070507	0	cholesterol	28,39	THP-1	50,55	cholesterol	THP-1	MESH:D002784	2736	Chemical	Gene	efflux|compound|START_ENTITY efflux|nmod|macrophages macrophages|compound|END_ENTITY	Oxidative stress influences cholesterol efflux in THP-1 macrophages : role of ATP-binding cassette A1 and nuclear factors .
17587765	0	cholesterol	21,32	THP-1	45,50	cholesterol	THP-1	MESH:D002784	2736	Chemical	Gene	efflux|compound|START_ENTITY enhances|dobj|efflux enhances|nmod|macrophages macrophages|compound|END_ENTITY	Telmisartan enhances cholesterol efflux from THP-1 macrophages by activating PPARgamma .
18988890	0	cholesterol	55,66	THP-1	77,82	cholesterol	THP-1	MESH:D002784	2736	Chemical	Gene	efflux|compound|START_ENTITY efflux|nmod|macrophages macrophages|compound|END_ENTITY	Endothelial_lipase promotes apolipoprotein AI-mediated cholesterol efflux in THP-1 macrophages .
19070858	0	cholesterol	87,98	THP-1	163,168	cholesterol	THP-1	MESH:D002784	2736	Chemical	Gene	efflux|compound|START_ENTITY reduces|dobj|efflux protein|dep|reduces protein|dep|kinase kinase|dobj|pathway pathway|nmod|cells cells|amod|macrophage-derived macrophage-derived|amod|END_ENTITY	Eicosapentaenoic_acid reduces ABCA1 serine phosphorylation and impairs ABCA1-dependent cholesterol efflux through cyclic_AMP / protein kinase A signaling pathway in THP-1 macrophage-derived foam cells .
19946756	0	cholesterol	14,25	THP-1	60,65	cholesterol	THP-1	MESH:D002784	2736	Chemical	Gene	transporter|compound|START_ENTITY inhibits|nsubj|transporter inhibits|dobj|apoptosis apoptosis|compound|END_ENTITY	Mitochondrial cholesterol transporter , StAR , inhibits human THP-1 monocyte-derived macrophage apoptosis .
20870032	0	cholesterol	30,41	THP-1	63,68	cholesterol	THP-1	MESH:D002784	2736	Chemical	Gene	homeostasis|compound|START_ENTITY disturbs|dobj|homeostasis disturbs|nmod|macrophages macrophages|compound|END_ENTITY	Chlamydia_pneumoniae disturbs cholesterol homeostasis in human THP-1 macrophages via JNK-PPARy dependent signal transduction pathways .
21111593	6	cholesterol	1133,1144	THP-1	1261,1266	cholesterol	IL-1b	MESH:D002784	3553	Chemical	Gene	efflux|compound|START_ENTITY effect|nmod|efflux had|dobj|effect had|advcl|had had|nmod|HDL HDL|nmod|macrophages macrophages|compound|END_ENTITY	Sitosterol had no effect on cholesterol efflux to Apo_AI or HDL , whereas campesterol had a modest but significant reduction in cholesterol efflux to HDL in THP-1 macrophages .
21111593	6	cholesterol	1232,1243	THP-1	1261,1266	cholesterol	IL-1b	MESH:D002784	3553	Chemical	Gene	efflux|compound|START_ENTITY reduction|nmod|efflux had|dobj|reduction had|nmod|HDL HDL|nmod|macrophages macrophages|compound|END_ENTITY	Sitosterol had no effect on cholesterol efflux to Apo_AI or HDL , whereas campesterol had a modest but significant reduction in cholesterol efflux to HDL in THP-1 macrophages .
21151462	0	cholesterol	46,57	THP-1	73,78	cholesterol	THP-1	MESH:D002784	2736	Chemical	Gene	fatty_acids|nmod|START_ENTITY homeostasis|nsubj|fatty_acids homeostasis|nmod|cells cells|compound|END_ENTITY	Polyunsaturated fatty_acids and modulation of cholesterol homeostasis in THP-1 macrophage-derived foam cells .
21336983	0	cholesterol	87,98	THP-1	135,140	cholesterol	THP-1	MESH:D002784	2736	Chemical	Gene	accumulation|compound|START_ENTITY accumulation|nmod|macrophages macrophages|compound|END_ENTITY	Receptor mediated elevation in FABP4 levels by advanced glycation end products induces cholesterol and triacylglycerol accumulation in THP-1 macrophages .
21871057	0	cholesterol	21,32	THP-1	91,96	cholesterol	THP-1	MESH:D002784	2736	Chemical	Gene	efflux|compound|START_ENTITY increases|dobj|efflux increases|nmod|inhibition inhibition|nmod|cells cells|amod|macrophage-derived macrophage-derived|amod|END_ENTITY	Walnut oil increases cholesterol efflux through inhibition of stearoyl_CoA desaturase 1 in THP-1 macrophage-derived foam cells .
22305277	0	cholesterol	83,94	THP-1	107,112	cholesterol	THP-1	MESH:D002784	2736	Chemical	Gene	efflux|compound|START_ENTITY promote|dobj|efflux promote|nmod|macrophages macrophages|compound|END_ENTITY	Ethanolic extracts of Brazilian red propolis increase ABCA1 expression and promote cholesterol efflux from THP-1 macrophages .
22429094	0	cholesterol	53,64	THP-1	77,82	cholesterol	THP-1	MESH:D002784	2736	Chemical	Gene	efflux|compound|START_ENTITY promotes|dobj|efflux promotes|nmod|macrophages macrophages|compound|END_ENTITY	Hesperetin upregulates ABCA1 expression and promotes cholesterol efflux from THP-1 macrophages .
23099443	6	cholesterol	1271,1282	THP-1	1293,1298	cholesterol	LOX-1	MESH:D002784	4973	Chemical	Gene	efflux|compound|START_ENTITY efflux|nmod|macrophages macrophages|compound|END_ENTITY	Accordingly , the hKv1.3-E314 antibody reduced percentage of cholesterol_ester and enhanced apoA-I-mediated cholesterol efflux in THP-1 macrophages and human monocyte-derived macrophages exposed to ox-LDL .
23305686	0	cholesterol	22,33	THP-1	80,85	cholesterol	THP-1	MESH:D002784	2736	Chemical	Gene	efflux|compound|START_ENTITY methylation|nsubj|efflux methylation|nmod|cells cells|compound|END_ENTITY	Homocysteine-mediated cholesterol efflux via ABCA1 and ACAT1 DNA methylation in THP-1 monocyte-derived foam cells .
23879935	0	cholesterol	48,59	THP-1	71,76	cholesterol	THP-1	MESH:D002784	2736	Chemical	Gene	content|compound|START_ENTITY decreases|dobj|content decreases|nmod|END_ENTITY	Polyunsaturated_fatty_acid relatively decreases cholesterol content in THP-1 macrophage-derived foam cell : partly correlates with expression profile of CIDE and PAT members .
24000379	0	cholesterol	67,78	THP-1	108,113	cholesterol	THP-1	MESH:D002784	2736	Chemical	Gene	expression|compound|START_ENTITY expression|nmod|macrophages macrophages|compound|END_ENTITY	Plasma from rheumatoid_arthritis patients promotes pro-atherogenic cholesterol transport gene expression in THP-1 human macrophages .
24140409	0	cholesterol	20,31	THP-1	44,49	cholesterol	THP-1	MESH:D002784	2736	Chemical	Gene	efflux|compound|START_ENTITY promotes|dobj|efflux promotes|nmod|macrophages macrophages|compound|END_ENTITY	Arctigenin promotes cholesterol efflux from THP-1 macrophages through PPAR-y/LXR-a signaling pathway .
24463979	0	cholesterol	34,45	THP-1	102,107	cholesterol	THP-1	MESH:D002784	2736	Chemical	Gene	efflux|compound|START_ENTITY enhanced|dobj|efflux enhanced|nmod|macrophages macrophages|compound|END_ENTITY	Interleukin_8 inhibition enhanced cholesterol efflux in acetylated low-density lipoprotein-stimulated THP-1 macrophages .
24608080	0	cholesterol	34,45	THP-1	94,99	cholesterol	THP-1	MESH:D002784	2736	Chemical	Gene	efflux|compound|START_ENTITY regulates|dobj|efflux regulates|nmod|macrophages macrophages|compound|END_ENTITY	MicroRNA-27a / b regulates cellular cholesterol efflux , influx and esterification/hydrolysis in THP-1 macrophages .
24751522	0	cholesterol	18,29	THP-1	84,89	cholesterol	THP-1	MESH:D002784	2736	Chemical	Gene	efflux|compound|START_ENTITY regulates|dobj|efflux regulates|advcl|targeting targeting|dobj|LXRa LXRa|nmod|macrophages macrophages|compound|END_ENTITY	miR-613 regulates cholesterol efflux by targeting LXRa and ABCA1 in PPARy activated THP-1 macrophages .
25329888	0	cholesterol	43,54	THP-1	91,96	cholesterol	THP-1	MESH:D002784	2736	Chemical	Gene	miR-33a-5P|nmod|START_ENTITY efflux|amod|miR-33a-5P efflux|nmod|stress stress|nmod|END_ENTITY	Effects of miR-33a-5P on ABCA1/G1-mediated cholesterol efflux under inflammatory stress in THP-1 macrophages .
25573889	0	cholesterol	7,18	THP-1	46,51	cholesterol	THP-1	MESH:D002784	2736	Chemical	Gene	capacity|compound|START_ENTITY capacity|nmod|macrophages macrophages|compound|END_ENTITY	Plasma cholesterol efflux capacity from human THP-1 macrophages is reduced in HIV-infected patients : impact of HAART .
26721343	0	cholesterol	17,28	THP-1	83,88	cholesterol	THP-1	MESH:D002784	2736	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|macrophages macrophages|compound|END_ENTITY	Imatinib reduces cholesterol uptake and matrix metalloproteinase activity in human THP-1 macrophages .
26859197	0	cholesterol	58,69	THP-1	80,85	cholesterol	THP-1	MESH:D002784	2736	Chemical	Gene	efflux|compound|START_ENTITY prompts|dobj|efflux prompts|nmod|cells cells|compound|END_ENTITY	Saikosaponin-a attenuates oxidized LDL uptake and prompts cholesterol efflux in THP-1 cells .
8084280	0	cholesterol	73,84	THP-1	101,106	cholesterol	THP-1	MESH:D002784	2736	Chemical	Gene	accumulation|compound|START_ENTITY increase|dobj|accumulation increase|nmod|macrophages macrophages|compound|END_ENTITY	Diabetic postprandial triglyceride-rich lipoproteins increase esterified cholesterol accumulation in THP-1 macrophages .
8257450	0	cholesterol	28,39	THP-1	58,63	cholesterol	THP-1	MESH:D002784	2736	Chemical	Gene	esterification|compound|START_ENTITY esterification|nmod|END_ENTITY	Effect of hyperapo B LDL on cholesterol esterification in THP-1 macrophages .
8608733	0	cholesterol	116,127	THP-1	144,149	cholesterol	THP-1	MESH:D002784	2736	Chemical	Gene	biosynthesis|compound|START_ENTITY changes|nmod|biosynthesis correlate|nmod|changes correlate|nmod|macrophages macrophages|compound|END_ENTITY	Changes in free cholesterol content , measured by filipin fluorescence and flow cytometry , correlate with changes in cholesterol biosynthesis in THP-1 macrophages .
8608733	0	cholesterol	16,27	THP-1	144,149	cholesterol	THP-1	MESH:D002784	2736	Chemical	Gene	content|compound|START_ENTITY Changes|nmod|content correlate|nsubj|Changes correlate|nmod|macrophages macrophages|compound|END_ENTITY	Changes in free cholesterol content , measured by filipin fluorescence and flow cytometry , correlate with changes in cholesterol biosynthesis in THP-1 macrophages .
8645354	0	cholesterol	25,36	THP-1	78,83	cholesterol	THP-1	MESH:D002784	2736	Chemical	Gene	mobilisation|nmod|START_ENTITY cholesteryl_esters|nsubj|mobilisation cholesteryl_esters|nmod|macrophages macrophages|appos|END_ENTITY	Impaired mobilisation of cholesterol from stored cholesteryl_esters in human -LRB- THP-1 -RRB- macrophages .
9869653	0	cholesterol	28,39	THP-1	86,91	cholesterol	THP-1	MESH:D002784	2736	Chemical	Gene	release|compound|START_ENTITY release|nmod|cells cells|compound|END_ENTITY	Apolipoprotein_A-I promotes cholesterol release and apolipoprotein_E recruitment from THP-1 macrophage-like foam cells .
16971496	0	cholesterol	95,106	THP1	125,129	cholesterol	THP1	MESH:D002784	2736	Chemical	Gene	efflux|compound|START_ENTITY efflux|nmod|macrophages macrophages|compound|END_ENTITY	Stable overexpression of human macrophage cholesteryl_ester_hydrolase results in enhanced free cholesterol efflux from human THP1 macrophages .
25657311	7	cholesterol	1430,1441	TLR5	1381,1385	cholesterol	TLR2	MESH:D002784	7097	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	In women , TLR1 , TLR3 , TLR6 , and TLR7 were associated with body mass index and TLR5 , TLR7 , and TLR10 were associated with total cholesterol to high-density lipoprotein ratio .
23914732	0	cholesterol	11,22	TNFa	0,4	cholesterol	TNFa	MESH:D002784	7124	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|compound|END_ENTITY	TNFa alter cholesterol metabolism in human macrophages via PKC - - dependent pathway .
16800863	0	cholesterol	29,40	TRPV1	0,5	cholesterol	TRPV1	MESH:D002784	83810(Tax:10116)	Chemical	Gene	requires|dobj|START_ENTITY requires|nsubj|END_ENTITY	TRPV1 , but not P2X , requires cholesterol for its function and membrane expression in rat nociceptors .
25035345	0	cholesterol	59,70	Transmembrane_protein_55B	0,25	cholesterol	Transmembrane protein 55B	MESH:D002784	90809	Chemical	Gene	metabolism|compound|START_ENTITY regulator|nmod|metabolism regulator|nsubj|END_ENTITY	Transmembrane_protein_55B is a novel regulator of cellular cholesterol metabolism .
21740188	0	cholesterol	67,78	UBIAD1	44,50	cholesterol	UBIAD1	MESH:D002784	29914	Chemical	Gene	modulates|dobj|START_ENTITY modulates|nsubj|TERE1 TERE1|appos|END_ENTITY	The bladder_tumor suppressor protein TERE1 -LRB- UBIAD1 -RRB- modulates cell cholesterol : implications for tumor progression .
23169578	0	cholesterol	74,85	UBIAD1	4,10	cholesterol	UBIAD1	MESH:D002784	29914	Chemical	Gene	enzymes|compound|START_ENTITY corrected|nmod|enzymes -LSB-|acl|corrected links|dobj|-LSB- links|nsubj|prenyltransferase prenyltransferase|compound|END_ENTITY	The UBIAD1 prenyltransferase links menaquinone-4 -LSB- corrected -RSB- synthesis to cholesterol metabolic enzymes .
23759948	0	cholesterol	217,228	UBIAD1	33,39	cholesterol	UBIAD1	MESH:D002784	29914	Chemical	Gene	metabolism|compound|START_ENTITY involved|nmod|metabolism genes|acl|involved associated|nmod|genes phenotype|acl|associated growth|dep|phenotype inhibits|dobj|growth inhibits|nsubj|expression expression|nmod|protein protein|appos|END_ENTITY	Ectopic expression of the TERE1 -LRB- UBIAD1 -RRB- protein inhibits growth of renal_clear_cell_carcinoma cells : altered metabolic phenotype associated with reactive oxygen species , nitric_oxide and SXR target genes involved in cholesterol and lipid metabolism .
23919967	0	cholesterol	77,88	UBIAD1	28,34	cholesterol	UBIAD1	MESH:D002784	29914	Chemical	Gene	phenotype|compound|START_ENTITY regulates|dobj|phenotype regulates|nsubj|TERE1 TERE1|appos|END_ENTITY	The tumor suppressor TERE1 -LRB- UBIAD1 -RRB- prenyltransferase regulates the elevated cholesterol phenotype in castration resistant prostate_cancer by controlling a program of ligand dependent SXR target genes .
15131762	0	cholesterol	62,73	adiponectin	6,17	cholesterol	adiponectin	MESH:D002784	9370	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	Serum adiponectin is associated with high-density lipoprotein cholesterol , triglycerides , and low-density lipoprotein particle size in young healthy men .
16739100	0	cholesterol	28,39	adiponectin	6,17	cholesterol	adiponectin	MESH:D002784	9370	Chemical	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	Serum adiponectin levels in cholesterol and pigment cholelithiasis .
16919535	0	cholesterol	64,75	adiponectin	6,17	cholesterol	adiponectin	MESH:D002784	9370	Chemical	Gene	related|nmod|START_ENTITY related|nsubjpass|END_ENTITY	Serum adiponectin is related to plasma high-density lipoprotein cholesterol but not to plasma insulin-concentration in healthy children : the FLVS II study .
19154945	0	cholesterol	47,58	adiponectin	74,85	cholesterol	adiponectin	MESH:D002784	9370	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Glimepiride increases high-density lipoprotein cholesterol via increasing adiponectin levels in type_2_diabetes_mellitus .
20678904	0	cholesterol	52,63	adiponectin	110,121	cholesterol	adiponectin	MESH:D002784	9370	Chemical	Gene	apolipoprotein_A-I|compound|START_ENTITY END_ENTITY|compound|apolipoprotein_A-I	Short term dietary sodium restriction decreases HDL cholesterol , apolipoprotein_A-I and high molecular weight adiponectin in healthy young men : relationships with renal hemodynamics and RAAS activation .
21740892	0	cholesterol	26,37	adiponectin	48,59	cholesterol	adiponectin	MESH:D002784	9370	Chemical	Gene	efflux|compound|START_ENTITY increasing|dobj|efflux increasing|nmod|END_ENTITY	Possibility of increasing cholesterol efflux by adiponectin and its receptors through the ATP_binding_cassette_transporter_A1 in HEK293T cells .
24460637	10	cholesterol	1435,1446	adiponectin	1518,1529	cholesterol	adiponectin	MESH:D002784	9370	Chemical	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	In multivariate linear regression models , body fat percentage and albumin -LRB- P < 0.05 -RRB- were negatively associated with adiponectin , and high-density lipoprotein cholesterol -LRB- HDL-C -RRB- -LRB- P < 0.001 -RRB- and age -LRB- P < 0.01 -RRB- were positively associated with adiponectin in older males .
12729921	0	cholesterol	56,67	albumin	12,19	cholesterol	albumin	MESH:D002784	213	Chemical	Gene	efflux|compound|START_ENTITY mediate|dobj|efflux mediate|nsubj|END_ENTITY	Human serum albumin and its structural variants mediate cholesterol efflux from cultured endothelial cells .
23224873	0	cholesterol	135,146	alpha-MSH	114,123	cholesterol	alpha-MSH	MESH:D002784	5443	Chemical	Gene	homeostasis|compound|START_ENTITY homeostasis|amod|END_ENTITY	NCKX5 , a natural regulator of human skin colour variation , regulates the expression of key pigment genes MC1R and alpha-MSH and alters cholesterol homeostasis in normal human melanocytes .
11843265	0	cholesterol	32,43	aminopeptidase_A	47,63	cholesterol	aminopeptidase A	MESH:D002784	13809(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Differential effects of dietary cholesterol on aminopeptidase_A , B and M in the frontal cortex of male and female mice .
19625658	0	cholesterol	31,42	amyloid_precursor_protein	70,95	cholesterol	amyloid precursor protein	MESH:D002784	11820(Tax:10090)	Chemical	Gene	trafficking|compound|START_ENTITY trafficking|compound|END_ENTITY	Inhibition of acyl-coenzyme_A : cholesterol acyl transferase modulates amyloid_precursor_protein trafficking in the early secretory pathway .
20005956	0	cholesterol	44,55	angiotensin_II	15,29	cholesterol	angiotensin II	MESH:D002784	183	Chemical	Gene	absorption|compound|START_ENTITY Involvement|nmod|absorption Involvement|nmod|END_ENTITY	Involvement of angiotensin_II in intestinal cholesterol absorption .
9188103	0	cholesterol	110,121	annexin_II	35,45	cholesterol	annexin II	MESH:D002784	302	Chemical	Gene	release|nmod|START_ENTITY release|nmod|END_ENTITY	Specific release of membrane-bound annexin_II and cortical cytoskeletal elements by sequestration of membrane cholesterol .
10191288	0	cholesterol	101,112	apoA-I	139,145	cholesterol	apoA-I	MESH:D002784	335	Chemical	Gene	reduce|dobj|START_ENTITY reduce|nmod|transgenic_mice transgenic_mice|compound|END_ENTITY	Expression of serum_amyloid_A protein in the absence of the acute phase response does not reduce HDL cholesterol or apoA-I levels in human apoA-I transgenic_mice .
12117740	0	cholesterol	73,84	apoA-I	133,139	cholesterol	apoA-I	MESH:D002784	335	Chemical	Gene	levels|nmod|START_ENTITY decreased|dobj|levels decreased|advcl|inflammation inflammation|nmod|transgenic_mice transgenic_mice|compound|END_ENTITY	Human secretory_phospholipase_A2 mediates decreased plasma levels of HDL cholesterol and apoA-I in response to inflammation in human apoA-I transgenic_mice .
14644392	0	cholesterol	19,30	apoA-I	57,63	cholesterol	apoA-I	MESH:D002784	11806(Tax:10090)	Chemical	Gene	removed|nsubjpass|START_ENTITY removed|nmod|END_ENTITY	Cytotoxic cellular cholesterol is selectively removed by apoA-I via ABCA1 .
16357317	0	cholesterol	37,48	apoA-I	59,65	cholesterol	apoA-I	MESH:D002784	335	Chemical	Gene	export|compound|START_ENTITY mediate|dobj|export mediate|nmod|END_ENTITY	ABCA1 and ABCG1 synergize to mediate cholesterol export to apoA-I .
17071966	0	cholesterol	22,33	apoA-I	46,52	cholesterol	apoA-I	MESH:D002784	11806(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|LDLr LDLr|dep|END_ENTITY	Inflammation and skin cholesterol in LDLr - / - , apoA-I - / - mice : link between cholesterol homeostasis and self-tolerance ?
17071966	0	cholesterol	75,86	apoA-I	46,52	cholesterol	apoA-I	MESH:D002784	11806(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY link|nmod|homeostasis mice|dep|link cholesterol|dep|mice cholesterol|nmod|LDLr LDLr|dep|END_ENTITY	Inflammation and skin cholesterol in LDLr - / - , apoA-I - / - mice : link between cholesterol homeostasis and self-tolerance ?
17506726	5	cholesterol	940,951	apoA-I	994,1000	cholesterol	apoA-I	MESH:D002784	11806(Tax:10090)	Chemical	Gene	START_ENTITY|acl|expressing expressing|dep|END_ENTITY	The total plasma cholesterol of mice expressing the apoA-I -LRB- R160L -RRB- Oslo , apoA-I -LRB- R149A -RRB- and apoA-I -LRB- R151C -RRB- Paris mutants was reduced by 78 , 59 and 61 % and the apoA-I levels were reduced by 68 , 64 and 55 % respectively , as compared with mice expressing the WT apoA-I .
18708026	5	cholesterol	1031,1042	apoA-I	915,921	cholesterol	apoA-I	MESH:D002784	335	Chemical	Gene	efflux|compound|START_ENTITY rates|nmod|efflux determining|dobj|rates investigated|advcl|determining investigated|nsubjpass|role role|nmod|recycling recycling|compound|END_ENTITY	A possible role of apoA-I recycling in the mechanism of cholesterol efflux was investigated by determining the rates of apoA-I induced cholesterol efflux and apoA-I recycling in the presence and in the absence of Brefeldin_A -LRB- BFA -RRB- .
18708026	5	cholesterol	952,963	apoA-I	915,921	cholesterol	apoA-I	MESH:D002784	335	Chemical	Gene	efflux|compound|START_ENTITY mechanism|nmod|efflux recycling|nmod|mechanism recycling|compound|END_ENTITY	A possible role of apoA-I recycling in the mechanism of cholesterol efflux was investigated by determining the rates of apoA-I induced cholesterol efflux and apoA-I recycling in the presence and in the absence of Brefeldin_A -LRB- BFA -RRB- .
19847320	0	cholesterol	50,61	apoA-I	3,9	cholesterol	apoA-I	MESH:D002784	335	Chemical	Gene	facilitates|dobj|START_ENTITY facilitates|nsubj|peptide peptide|amod|END_ENTITY	An apoA-I mimetic peptide facilitates off-loading cholesterol from HDL to liver cells through scavenger receptor BI .
19932961	0	cholesterol	52,63	apoA-I	13,19	cholesterol	apoA-I	MESH:D002784	335	Chemical	Gene	efflux|compound|START_ENTITY stimulate|dobj|efflux mimetics|acl:relcl|stimulate peptide|dobj|mimetics peptide|nsubj|END_ENTITY	Novel potent apoA-I peptide mimetics that stimulate cholesterol efflux and pre-beta particle formation in vitro .
20360851	0	cholesterol	59,70	apoA-I	17,23	cholesterol	apoA-I	MESH:D002784	11806(Tax:10090)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Enhanced hepatic apoA-I secretion and peripheral efflux of cholesterol and phospholipid in CD36 null mice .
20642861	0	cholesterol	20,31	apoA-I	10,16	cholesterol	apoA-I	MESH:D002784	335	Chemical	Gene	release|compound|START_ENTITY END_ENTITY|nmod|release	Effect of apoA-I on cholesterol release and apoE secretion in human mature adipocytes .
21449977	0	cholesterol	84,95	apoA-I	115,121	cholesterol	apoA-I	MESH:D002784	335	Chemical	Gene	transport|compound|START_ENTITY transport|nmod|transgenic_mice transgenic_mice|compound|END_ENTITY	The thienotriazolodiazepine_Ro_11-1464 increases plasma apoA-I and promotes reverse cholesterol transport in human apoA-I transgenic_mice .
21449977	0	cholesterol	84,95	apoA-I	56,62	cholesterol	apoA-I	MESH:D002784	335	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|dobj|transport	The thienotriazolodiazepine_Ro_11-1464 increases plasma apoA-I and promotes reverse cholesterol transport in human apoA-I transgenic_mice .
8172849	0	cholesterol	10,21	apoA-I	47,53	cholesterol	apoA-I	MESH:D002784	335	Chemical	Gene	levels|compound|START_ENTITY determined|nsubjpass|levels determined|nmod|rate rate|amod|END_ENTITY	Human HDL cholesterol levels are determined by apoA-I fractional catabolic rate , which correlates inversely with estimates of HDL particle size .
8428938	1	cholesterol	175,186	apoA-I	207,213	cholesterol	apoA-I	MESH:D002784	11806(Tax:10090)	Chemical	Gene	promotion|compound|START_ENTITY promotion|nmod|END_ENTITY	Evidence for reduced cholesterol efflux promotion by apoA-I -LRB- Pro165 -- > Arg -RRB- .
8864954	0	cholesterol	43,54	apoA-I	90,96	cholesterol	apoA-I	MESH:D002784	335	Chemical	Gene	efflux|nmod|START_ENTITY phospholipid|nmod|efflux HDL|acl|phospholipid Role|nmod|HDL Role|dep|studies studies|nmod|rats rats|amod|END_ENTITY	Role of HDL phospholipid in efflux of cell cholesterol to whole serum : studies with human apoA-I transgenic rats .
9538003	1	cholesterol	248,259	apoA-I	201,207	cholesterol	apoA-I	MESH:D002784	335	Chemical	Gene	efflux|nmod|START_ENTITY role|nmod|efflux has|dobj|role has|nsubj|apolipoprotein_A-I apolipoprotein_A-I|appos|END_ENTITY	Human apolipoprotein_A-I -LRB- apoA-I -RRB- has an important role in the efflux of cholesterol from peripheral cells , the first step in reverse cholesterol transport .
9538003	1	cholesterol	309,320	apoA-I	201,207	cholesterol	apoA-I	MESH:D002784	335	Chemical	Gene	transport|compound|START_ENTITY step|nmod|transport cells|appos|step has|nmod|cells has|nsubj|apolipoprotein_A-I apolipoprotein_A-I|appos|END_ENTITY	Human apolipoprotein_A-I -LRB- apoA-I -RRB- has an important role in the efflux of cholesterol from peripheral cells , the first step in reverse cholesterol transport .
19434059	0	cholesterol	43,54	apoB100	87,94	cholesterol	apoB100	MESH:D002784	338	Chemical	Gene	levels|compound|START_ENTITY levels|nmod|secretion secretion|amod|END_ENTITY	Knockdown of FABP5 mRNA decreases cellular cholesterol levels and results in decreased apoB100 secretion and triglyceride accumulation in ARPE-19 cells .
20508649	0	cholesterol	43,54	apoB100	87,94	cholesterol	apoB100	MESH:D002784	338	Chemical	Gene	levels|compound|START_ENTITY levels|nmod|secretion secretion|amod|END_ENTITY	Knockdown of FABP5 mRNA decreases cellular cholesterol levels and results in decreased apoB100 secretion and triglyceride accumulation in ARPE-19 cells .
10725355	5	cholesterol	849,860	apoE	960,964	cholesterol	apoE	MESH:D002784	11816(Tax:10090)	Chemical	Gene	increase|nmod|START_ENTITY increased|nsubj|increase was|advcl|increased was|nsubj|increase increase|nmod|mice mice|amod|END_ENTITY	Whereas in wild-type mice , the increase in dietary cholesterol increased the hepatic excretion of biliary cholesterol 4-fold , there was only a 2-fold increase in apoE knockout mice .
10725355	5	cholesterol	904,915	apoE	960,964	cholesterol	apoE	MESH:D002784	11816(Tax:10090)	Chemical	Gene	4-fold|compound|START_ENTITY excretion|nmod|4-fold increased|dobj|excretion was|advcl|increased was|nsubj|increase increase|nmod|mice mice|amod|END_ENTITY	Whereas in wild-type mice , the increase in dietary cholesterol increased the hepatic excretion of biliary cholesterol 4-fold , there was only a 2-fold increase in apoE knockout mice .
11352738	7	cholesterol	1052,1063	apoE	1021,1025	cholesterol	apoE	MESH:D002784	11816(Tax:10090)	Chemical	Gene	levels|compound|START_ENTITY mice|compound|levels normalized|dobj|mice normalized|nsubj|adenovirus adenovirus|acl|expressing expressing|dobj|form form|amod|END_ENTITY	In contrast , an adenovirus expressing the truncated apoE 1-185 form normalized the cholesterol levels of E -LRB- - -RRB- -LRB- / -RRB- -LRB- - -RRB- mice and did not cause hypertriglyceridemia .
12475897	0	cholesterol	80,91	apoE	108,112	cholesterol	apoE	MESH:D002784	348	Chemical	Gene	START_ENTITY|nmod|deficiency deficiency|amod|END_ENTITY	Pharmacological interference with intestinal bile_acid transport reduces plasma cholesterol in LDL_receptor / apoE deficiency .
12518038	0	cholesterol	25,36	apoE	76,80	cholesterol	apoE	MESH:D002784	348	Chemical	Gene	absorption|compound|START_ENTITY Efficiency|nmod|absorption related|nsubjpass|Efficiency related|xcomp|END_ENTITY	Efficiency of intestinal cholesterol absorption in humans is not related to apoE phenotype .
1402403	0	cholesterol	98,109	apoE	139,143	cholesterol	apoE	MESH:D002784	348	Chemical	Gene	intake|compound|START_ENTITY intake|nmod|men men|nmod|phenotypes phenotypes|compound|END_ENTITY	Cholesterol absorption and synthesis related to low density lipoprotein metabolism during varying cholesterol intake in men with different apoE phenotypes .
16190879	0	cholesterol	26,37	apoE	52,56	cholesterol	apoE	MESH:D002784	11816(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY Regulation|nmod|metabolism Regulation|nmod|stimulation stimulation|amod|END_ENTITY	Regulation of hippocampal cholesterol metabolism by apoE and environmental stimulation .
16376010	0	cholesterol	32,43	apoE	15,19	cholesterol	apoE	MESH:D002784	25728(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY isoforms|nmod|metabolism isoforms|amod|END_ENTITY	Implication of apoE isoforms in cholesterol metabolism by primary rat hippocampal neurons and astrocytes .
16670775	0	cholesterol	67,78	apoE	109,113	cholesterol	apoE	MESH:D002784	348	Chemical	Gene	efflux|compound|START_ENTITY promote|dobj|efflux promote|nmod|macrophages macrophages|nmod|pathway pathway|amod|END_ENTITY	HDL from CETP-deficient subjects shows enhanced ability to promote cholesterol efflux from macrophages in an apoE - and ABCG1-dependent pathway .
16981222	0	cholesterol	33,44	apoE	148,152	cholesterol	apoE	MESH:D002784	11816(Tax:10090)	Chemical	Gene	efflux|compound|START_ENTITY promotes|dobj|efflux promotes|nmod|cells cells|nmod|PPARgamma-LXRalpha-ABCA1-dependent PPARgamma-LXRalpha-ABCA1-dependent|acl|associated associated|nmod|END_ENTITY	Lysophosphatidylcholine promotes cholesterol efflux from mouse macrophage foam cells via PPARgamma-LXRalpha-ABCA1-dependent pathway associated with apoE .
17299204	0	cholesterol	17,28	apoE	64,68	cholesterol	apoE	MESH:D002784	11816(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY altered|dobj|homeostasis altered|nmod|macrophages macrophages|acl|lacking lacking|xcomp|END_ENTITY	Severely altered cholesterol homeostasis in macrophages lacking apoE and SR-BI .
19713443	3	cholesterol	564,575	apoE	610,614	cholesterol	apoE	MESH:D002784	25728(Tax:10116)	Chemical	Gene	increase|nmod|START_ENTITY increase|nmod|secretion secretion|appos|END_ENTITY	Src inhibitors also suppressed FGF-1-induced increase of biosynthesis and release of cholesterol and increase of apolipoprotein_E -LRB- apoE -RRB- secretion .
20177736	0	cholesterol	25,36	apoE	130,134	cholesterol	apoE	MESH:D002784	11816(Tax:10090)	Chemical	Gene	induce|nsubj|START_ENTITY induce|nmod|recruitment recruitment|acl|circulating circulating|nmod|END_ENTITY	High fat diet containing cholesterol induce aortic_aneurysm through recruitment and proliferation of circulating agranulocytes in apoE knock out mice model .
21034469	1	cholesterol	196,207	apoE	179,183	cholesterol	apoE	MESH:D002784	348	Chemical	Gene	protein|compound|START_ENTITY Apolipoprotein_E|acl:relcl|protein Apolipoprotein_E|appos|END_ENTITY	BACKGROUND : Apolipoprotein_E -LRB- apoE -RRB- is a major cholesterol transport protein found in association with brain amyloid from Alzheimer 's _ disease -LRB- AD -RRB- patients and the 4 allele of apoE is a genetic risk factor for AD .
21257611	0	cholesterol	38,49	apoE	104,108	cholesterol	apoE	MESH:D002784	11816(Tax:10090)	Chemical	Gene	absorption|compound|START_ENTITY effects|nmod|absorption effects|nmod|END_ENTITY	Differential effects on inhibition of cholesterol absorption by plant stanol and plant sterol_esters in apoE - / - mice .
21258856	0	cholesterol	112,123	apoE	50,54	cholesterol	apoE	MESH:D002784	348	Chemical	Gene	transport|compound|START_ENTITY stimulated|dobj|transport receptor|acl|stimulated contributes|nmod|receptor contributes|nsubj|END_ENTITY	Cholesterol 27-hydroxylase but not apolipoprotein apoE contributes to A2A adenosine receptor stimulated reverse cholesterol transport .
24314261	0	cholesterol	50,61	apoE	139,143	cholesterol	apoE	MESH:D002784	11816(Tax:10090)	Chemical	Gene	efflux|compound|START_ENTITY stimulate|dobj|efflux stimulate|advcl|reduce reduce|nmod|mice mice|amod|END_ENTITY	The combination of L-4F and simvastatin stimulate cholesterol efflux and related proteins expressions to reduce atherosclerotic_lesions in apoE knockout mice .
2477479	0	cholesterol	98,109	apoE	27,31	cholesterol	apoE	MESH:D002784	11816(Tax:10090)	Chemical	Gene	efflux|compound|START_ENTITY effect|nmod|efflux Synthesis|dep|effect Synthesis|nmod|macrophages macrophages|amod|END_ENTITY	Synthesis and secretion of apoE in thioglycolate-elicited mouse peritoneal macrophages : effect of cholesterol efflux .
24814386	0	cholesterol	90,101	apoE	24,28	cholesterol	apoE	MESH:D002784	25728(Tax:10116)	Chemical	Gene	using|dobj|START_ENTITY generates|xcomp|using generates|nsubj|END_ENTITY	Astrocyte s endogenous apoE generates HDL-like lipoproteins using previously synthesized cholesterol through interaction with ABCA1 .
3624230	6	cholesterol	858,869	apoE	921,925	cholesterol	apoE	MESH:D002784	11816(Tax:10090)	Chemical	Gene	Removing|dobj|START_ENTITY returned|csubj|Removing returned|dobj|rates rates|amod|END_ENTITY	Removing free cholesterol from cells using high density lipoprotein returned apoE synthetic rates toward base line .
21492516	0	cholesterol	134,145	apoM	87,91	cholesterol	apoM	MESH:D002784	55937	Chemical	Gene	-RSB-|compound|START_ENTITY Effect|nmod|-RSB- Effect|nmod|END_ENTITY	-LSB- Effect of interfering hepatocyte nuclear factor-1 alfa in HepG2 on the expressions of apoM , apoA-I and the correlative key enzyme of cholesterol metabolism -RSB- .
10407497	0	cholesterol	114,125	apolipoprotein_A-I	21,39	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	efflux|nmod|START_ENTITY enhance|dobj|efflux enhance|nsubj|levels levels|nmod|END_ENTITY	High levels of human apolipoprotein_A-I and high density lipoproteins in transgenic_mice do not enhance efflux of cholesterol from a depot of injected lipoproteins .
10428843	0	cholesterol	94,105	apolipoprotein_A-I	188,206	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	efflux|compound|START_ENTITY lipoprotein-induced|dobj|efflux lipoprotein-induced|nmod|truncation truncation|nmod|terminus terminus|nmod|END_ENTITY	Matrix_metalloproteinases-3 , _ -7 , _ and _ -12 , but not -9 , reduce high density lipoprotein-induced cholesterol efflux from human macrophage foam cells by truncation of the carboxyl terminus of apolipoprotein_A-I .
10967614	0	cholesterol	107,118	apolipoprotein_A-I	151,169	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	efflux|compound|START_ENTITY efflux|nmod|mice mice|acl|expressing expressing|dobj|END_ENTITY	Effects of dietary maritime pine -LRB- Pinus pinaster -RRB- - seed oil on high-density lipoprotein levels and in vitro cholesterol efflux in mice expressing human apolipoprotein_A-I .
11425766	0	cholesterol	66,77	apolipoprotein_A-I	22,40	cholesterol	apolipoprotein A-I	MESH:D002784	11806(Tax:10090)	Chemical	Gene	mobilizes|dobj|START_ENTITY mobilizes|nsubj|END_ENTITY	High-dose recombinant apolipoprotein_A-I -LRB- milano -RRB- mobilizes tissue cholesterol and rapidly reduces plaque lipid and macrophage content in apolipoprotein_e-deficient mice .
11478940	0	cholesterol	124,135	apolipoprotein_A-I	20,38	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	diet|compound|START_ENTITY reduces|nmod|diet Expression|parataxis|reduces Expression|nmod|END_ENTITY	Expression of human apolipoprotein_A-I / C-III/A-IV gene cluster in mice reduces atherogenesis in response to a high fat-high cholesterol diet .
11805090	0	cholesterol	55,66	apolipoprotein_A-I	103,121	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	fibroblasts|nmod|START_ENTITY Effects|nmod|fibroblasts Effects|nmod|efflux efflux|nmod|lipids lipids|nmod|END_ENTITY	Effects of enrichment of fibroblasts with unesterified cholesterol on the efflux of cellular lipids to apolipoprotein_A-I .
11916081	0	cholesterol	54,65	apolipoprotein_A-I	23,41	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	transport|compound|START_ENTITY transport|compound|END_ENTITY	Factor VII activation , apolipoprotein_A-I and reverse cholesterol transport : possible relevance for postprandial_lipaemia .
12050168	0	cholesterol	143,154	apolipoprotein_A-I	89,107	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	efflux|compound|START_ENTITY END_ENTITY|nmod|efflux	Trypsin-sensitive and lipid-containing sites of the macrophage extracellular matrix bind apolipoprotein_A-I and participate in ABCA1-dependent cholesterol efflux .
12117731	0	cholesterol	13,24	apolipoprotein_A-I	26,44	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	A-I|compound|START_ENTITY A-I|dep|END_ENTITY	Value of HDL cholesterol , apolipoprotein_A-I , lipoprotein A-I , and lipoprotein A-I/A-II in prediction of coronary_heart_disease : the PRIME Study .
12181325	0	cholesterol	67,78	apolipoprotein_A-I	12,30	cholesterol	apolipoprotein A-I	MESH:D002784	11806(Tax:10090)	Chemical	Gene	efflux|compound|START_ENTITY helix|nmod|efflux helix|nsubj|role role|nmod|END_ENTITY	The role of apolipoprotein_A-I helix 10 in apolipoprotein-mediated cholesterol efflux via the ATP-binding cassette transporter ABCA1 .
12890677	0	cholesterol	18,29	apolipoprotein_A-I	40,58	cholesterol	apolipoprotein A-I	MESH:D002784	100772590	Chemical	Gene	efflux|compound|START_ENTITY enhances|dobj|efflux enhances|advcl|END_ENTITY	Ceramide enhances cholesterol efflux to apolipoprotein_A-I by increasing the cell surface presence of ATP-binding_cassette_transporter_A1 .
12900335	0	cholesterol	67,78	apolipoprotein_A-I	18,36	cholesterol	apolipoprotein A-I	MESH:D002784	11806(Tax:10090)	Chemical	Gene	transport|nmod|START_ENTITY promotes|dobj|transport promotes|nsubj|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of apolipoprotein_A-I promotes reverse transport of cholesterol from macrophages to feces in vivo .
1301210	0	cholesterol	113,124	apolipoprotein_A-I	31,49	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	raises|dobj|START_ENTITY raises|nsubj|expression expression|nmod|END_ENTITY	High level expression of human apolipoprotein_A-I in transgenic rats raises total serum high density lipoprotein cholesterol and lowers rat apolipoprotein_A-I .
1420341	0	cholesterol	82,93	apolipoprotein_A-I	60,78	cholesterol	apolipoprotein A-I	MESH:D002784	25081(Tax:10116)	Chemical	Gene	efflux|compound|START_ENTITY containing|nmod|efflux containing|dobj|END_ENTITY	Differential effect of subspecies of lipoprotein containing apolipoprotein_A-I on cholesterol efflux from cholesterol-loaded macrophages : functional correlation with lecithin : _ cholesterol_acyltransferase .
1431577	0	cholesterol	124,135	apolipoprotein_A-I	35,53	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	levels|nmod|START_ENTITY associated|nmod|levels associated|nsubj|mechanisms mechanisms|nmod|concentrations concentrations|compound|END_ENTITY	Physiologic mechanisms for reduced apolipoprotein_A-I concentrations associated with low levels of high density lipoprotein cholesterol in patients with normal plasma lipids .
14510906	0	cholesterol	98,109	apolipoprotein_A-I	19,37	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	levels|compound|START_ENTITY Association|dep|levels Association|nmod|polymorphisms polymorphisms|amod|END_ENTITY	Association of two apolipoprotein_A-I gene MspI polymorphisms with high density lipoprotein -LRB- HDL -RRB- - cholesterol levels and indices of obesity in selected healthy Chinese subjects and in patients with early-onset type 2 diabetes .
1496008	0	cholesterol	45,56	apolipoprotein_A-I	94,112	cholesterol	apolipoprotein A-I	MESH:D002784	11806(Tax:10090)	Chemical	Gene	reduction|nmod|START_ENTITY genetically|nsubj|reduction genetically|dep|modified modified|nmod|END_ENTITY	Marked reduction of high density lipoprotein cholesterol in mice genetically modified to lack apolipoprotein_A-I .
15051721	0	cholesterol	82,93	apolipoprotein_A-I	21,39	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	efflux|compound|START_ENTITY mediates|dobj|efflux element|acl:relcl|mediates element|amod|END_ENTITY	Identification of an apolipoprotein_A-I structural element that mediates cellular cholesterol efflux and stabilizes ATP_binding_cassette_transporter_A1 .
16023124	0	cholesterol	76,87	apolipoprotein_A-I	17,35	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	causes|dobj|START_ENTITY causes|nsubj|mutation mutation|compound|END_ENTITY	A novel nonsense apolipoprotein_A-I mutation -LRB- apoA-I -LRB- E136X -RRB- -RRB- causes low HDL cholesterol in French Canadians .
16126721	0	cholesterol	63,74	apolipoprotein_A-I	131,149	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	export|compound|START_ENTITY ATP|dobj|export ATP|nmod|modification modification|nmod|END_ENTITY	Acrolein impairs ATP binding cassette transporter A1-dependent cholesterol export from cells through site-specific modification of apolipoprotein_A-I .
16151025	0	cholesterol	99,110	apolipoprotein_A-I	42,60	cholesterol	apolipoprotein A-I	MESH:D002784	11806(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY attributable|nmod|transport END_ENTITY|xcomp|attributable	Increased atherosclerosis in mice lacking apolipoprotein_A-I attributable to both impaired reverse cholesterol transport and increased inflammation .
16497665	0	cholesterol	40,51	apolipoprotein_A-I	131,149	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	efflux|compound|START_ENTITY impairs|dobj|efflux impairs|nmod|oxidation oxidation|nmod|END_ENTITY	Myeloperoxidase impairs ABCA1-dependent cholesterol efflux through methionine oxidation and site-specific tyrosine chlorination of apolipoprotein_A-I .
16990644	0	cholesterol	66,77	apolipoprotein_A-I	88,106	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	efflux|compound|START_ENTITY efflux|nmod|END_ENTITY	Ceramide structural features required to stimulate ABCA1-mediated cholesterol efflux to apolipoprotein_A-I .
18708026	0	cholesterol	21,32	apolipoprotein_A-I	106,124	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	efflux|compound|START_ENTITY inhibits|dobj|efflux inhibits|advcl|affecting affecting|dobj|rate rate|nmod|END_ENTITY	Brefeldin_A inhibits cholesterol efflux without affecting the rate of cellular uptake and re-secretion of apolipoprotein_A-I in adipocytes .
18719109	0	cholesterol	37,48	apolipoprotein_A-I	62,80	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	transport|compound|START_ENTITY impairs|dobj|transport impairs|nmod|END_ENTITY	Methionine oxidation impairs reverse cholesterol transport by apolipoprotein_A-I .
19055467	0	cholesterol	122,133	apolipoprotein_A-I	9,27	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	subjects|compound|START_ENTITY increased|nmod|subjects increased|nsubj|END_ENTITY	Nitrated apolipoprotein_A-I , a potential new cardiovascular marker , is markedly increased in low high-density lipoprotein cholesterol subjects .
19217440	0	cholesterol	182,193	apolipoprotein_A-I	121,139	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	A-I|compound|START_ENTITY polymorphisms|nmod|A-I polymorphisms|amod|END_ENTITY	Influence of cholesteryl_ester transfer protein , peroxisome proliferator-activated receptor alpha , apolipoprotein_E , and apolipoprotein_A-I polymorphisms on high-density lipoprotein cholesterol , apolipoprotein_A-I , lipoprotein A-I , and lipoprotein A-I : A-II concentrations : the Prospective Epidemiological Study of Myocardial_Infarction study .
19217440	0	cholesterol	182,193	apolipoprotein_A-I	195,213	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	A-I|compound|START_ENTITY A-I|dep|END_ENTITY	Influence of cholesteryl_ester transfer protein , peroxisome proliferator-activated receptor alpha , apolipoprotein_E , and apolipoprotein_A-I polymorphisms on high-density lipoprotein cholesterol , apolipoprotein_A-I , lipoprotein A-I , and lipoprotein A-I : A-II concentrations : the Prospective Epidemiological Study of Myocardial_Infarction study .
19605528	0	cholesterol	30,41	apolipoprotein_A-I	103,121	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	START_ENTITY|dep|ratios ratios|amod|END_ENTITY	Soy protein reduces serum LDL cholesterol and the LDL cholesterol : HDL cholesterol and apolipoprotein_B : apolipoprotein_A-I ratios in adults with type 2 diabetes .
19605528	0	cholesterol	70,81	apolipoprotein_A-I	103,121	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	cholesterol|dep|START_ENTITY cholesterol|dep|ratios ratios|amod|END_ENTITY	Soy protein reduces serum LDL cholesterol and the LDL cholesterol : HDL cholesterol and apolipoprotein_B : apolipoprotein_A-I ratios in adults with type 2 diabetes .
19667106	0	cholesterol	46,57	apolipoprotein_A-I	90,108	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	concentration|compound|START_ENTITY increases|dobj|concentration increases|nmod|stimulation stimulation|nmod|production production|compound|END_ENTITY	Nevirapine increases high-density lipoprotein cholesterol concentration by stimulation of apolipoprotein_A-I production .
19805625	0	cholesterol	102,113	apolipoprotein_A-I	132,150	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	ability|compound|START_ENTITY ability|nmod|Nichinan Nichinan|compound|END_ENTITY	Disruption of the C-terminal helix by single amino_acid deletion is directly responsible for impaired cholesterol efflux ability of apolipoprotein_A-I Nichinan .
20208418	0	cholesterol	54,65	apolipoprotein_A-I	9,27	cholesterol	apolipoprotein A-I	MESH:D002784	11806(Tax:10090)	Chemical	Gene	efflux|compound|START_ENTITY promotes|dobj|efflux promotes|nsubj|D-4F D-4F|appos|peptide peptide|amod|END_ENTITY	D-4F , an apolipoprotein_A-I mimetic peptide , promotes cholesterol efflux from macrophages via ATP-binding_cassette_transporter_A1 .
20378541	0	cholesterol	105,116	apolipoprotein_A-I	10,28	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	efflux|compound|START_ENTITY blocks|nsubj|efflux blocks|dep|Modifying Modifying|dobj|END_ENTITY	Modifying apolipoprotein_A-I by malondialdehyde , but not by an array of other reactive carbonyls , blocks cholesterol efflux by the ABCA1 pathway .
20826588	0	cholesterol	66,77	apolipoprotein_A-I	21,39	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	Genetically elevated apolipoprotein_A-I , high-density lipoprotein cholesterol levels , and risk of ischemic_heart_disease .
21071688	0	cholesterol	71,82	apolipoprotein_A-I	13,31	cholesterol	apolipoprotein A-I	MESH:D002784	11806(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY Influence|nmod|transport Influence|nmod|structure structure|amod|END_ENTITY	Influence of apolipoprotein_A-I domain structure on macrophage reverse cholesterol transport in mice .
21311139	0	cholesterol	50,61	apolipoprotein_A-I	11,29	cholesterol	apolipoprotein A-I	MESH:D002784	11806(Tax:10090)	Chemical	Gene	efflux|compound|START_ENTITY peptides|nmod|efflux peptides|amod|END_ENTITY	-LSB- Effect of apolipoprotein_A-I mimetic peptides on cholesterol efflux in RAW264 .7 cells -RSB- .
21317639	0	cholesterol	6,17	apolipoprotein_A-I	96,114	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	content|compound|START_ENTITY content|dep|correlation correlation|nmod|END_ENTITY	Total cholesterol content of erythrocyte membranes in acute_coronary_syndrome : correlation with apolipoprotein_A-I and lipoprotein -LRB- a -RRB- .
21858084	0	cholesterol	83,94	apolipoprotein_A-I	20,38	cholesterol	apolipoprotein A-I	MESH:D002784	11806(Tax:10090)	Chemical	Gene	efflux|compound|START_ENTITY required|nmod|efflux required|nsubjpass|sites sites|amod|END_ENTITY	Caveolin-1-mediated apolipoprotein_A-I membrane binding sites are not required for cholesterol efflux .
22105786	0	cholesterol	25,36	apolipoprotein_A-I	58,76	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	efflux|compound|START_ENTITY efflux|appos|nitration nitration|nmod|END_ENTITY	High-density lipoprotein cholesterol efflux , nitration of apolipoprotein_A-I , and endothelial function in obese women .
22178192	0	cholesterol	54,65	apolipoprotein_A-I	27,45	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	export|compound|START_ENTITY impairs|dobj|export impairs|nsubj|oxidation oxidation|nmod|END_ENTITY	Site-specific oxidation of apolipoprotein_A-I impairs cholesterol export by ABCA1 , a key cardioprotective function of HDL .
22399138	0	cholesterol	35,46	apolipoprotein_A-I	83,101	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	efflux|compound|START_ENTITY stimulates|dobj|efflux stimulates|advcl|increasing increasing|dobj|binding binding|nmod|END_ENTITY	IMB2026791 , a xanthone , stimulates cholesterol efflux by increasing the binding of apolipoprotein_A-I to ATP-binding_cassette_transporter_A1 .
22713542	0	cholesterol	62,73	apolipoprotein_A-I	101,119	cholesterol	apolipoprotein A-I	MESH:D002784	25081(Tax:10116)	Chemical	Gene	level|compound|START_ENTITY level|nmod|up-regulation up-regulation|nmod|expression expression|amod|END_ENTITY	High hydrostatic pressure extract of garlic increases the HDL cholesterol level via up-regulation of apolipoprotein_A-I gene expression in rats fed a high-fat diet .
23806608	0	cholesterol	76,87	apolipoprotein_A-I	20,38	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	regions|compound|START_ENTITY assisted|nmod|regions assisted|nsubj|mapping mapping|nmod|structure structure|compound|END_ENTITY	Mutation mapping of apolipoprotein_A-I structure assisted with the putative cholesterol recognition regions .
23874769	0	cholesterol	95,106	apolipoprotein_A-I	3,21	cholesterol	apolipoprotein A-I	MESH:D002784	11806(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY stimulates|dobj|transport stimulates|nsubj|peptide peptide|amod|END_ENTITY	An apolipoprotein_A-I mimetic peptide designed with a reductionist approach stimulates reverse cholesterol transport and reduces atherosclerosis in mice .
2500457	0	cholesterol	34,45	apolipoprotein_A-I	78,96	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	levels|compound|START_ENTITY correlate|nsubj|levels correlate|nmod|END_ENTITY	Elevated high density lipoprotein cholesterol levels correlate with decreased apolipoprotein_A-I and A-II fractional catabolic rate in women .
25550459	0	cholesterol	71,82	apolipoprotein_A-I	36,54	cholesterol	apolipoprotein A-I	MESH:D002784	11806(Tax:10090)	Chemical	Gene	capacity|compound|START_ENTITY END_ENTITY|dobj|capacity	Matrix_metalloproteinase_8 degrades apolipoprotein_A-I and reduces its cholesterol efflux capacity .
26005953	0	cholesterol	79,90	apolipoprotein_A-I	16,34	cholesterol	apolipoprotein A-I	MESH:D002784	11806(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY promotes|dobj|transport promotes|nsubj|END_ENTITY	Newly developed apolipoprotein_A-I mimetic peptide promotes macrophage reverse cholesterol transport in vivo .
26797122	0	cholesterol	100,111	apolipoprotein_A-I	70,88	cholesterol	Apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	loop|compound|START_ENTITY investigation|dep|loop investigation|nmod|requirements requirements|nmod|END_ENTITY	A systematic investigation of structure/function requirements for the apolipoprotein_A-I - lecithin cholesterol acyltransferase interaction loop of HDL .
2907746	0	cholesterol	136,147	apolipoprotein_A-I	20,38	cholesterol	apolipoprotein A-I	MESH:D002784	100126737(Tax:9555)	Chemical	Gene	metabolism|compound|START_ENTITY studies|nmod|metabolism polymorphisms|nmod|studies clone|nmod|polymorphisms characterization|nmod|clone gene|dep|characterization gene|nmod|END_ENTITY	The baboon gene for apolipoprotein_A-I : characterization of a cDNA clone and identification of DNA polymorphisms for genetic studies of cholesterol metabolism .
6411712	0	cholesterol	151,162	apolipoprotein_A-I	76,94	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	amounts|nmod|START_ENTITY containing|dobj|amounts complexes|acl|containing complexes|nmod|END_ENTITY	Reaction of lecithin : cholesterol acyltransferase with micellar complexes of apolipoprotein_A-I and phosphatidylcholine , containing variable amounts of cholesterol .
6411712	0	cholesterol	21,32	apolipoprotein_A-I	76,94	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	acyltransferase|compound|START_ENTITY acyltransferase|nmod|complexes complexes|nmod|END_ENTITY	Reaction of lecithin : cholesterol acyltransferase with micellar complexes of apolipoprotein_A-I and phosphatidylcholine , containing variable amounts of cholesterol .
7511599	0	cholesterol	80,91	apolipoprotein_A-I	19,37	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	efflux|compound|START_ENTITY critical|nmod|efflux epitope|xcomp|critical epitope|nsubj|Localization Localization|nmod|END_ENTITY	Localization of an apolipoprotein_A-I epitope critical for lipoprotein-mediated cholesterol efflux from monocytic cells .
7515687	0	cholesterol	135,146	apolipoprotein_A-I	18,36	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	efflux|nmod|START_ENTITY expressed|nmod|efflux expressed|nsubj|epitope epitope|nmod|END_ENTITY	Unique epitope of apolipoprotein_A-I expressed in pre-beta-1 high-density lipoprotein and its role in the catalyzed efflux of cellular cholesterol .
7615839	0	cholesterol	30,41	apolipoprotein_A-I	63,81	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	removal|nmod|START_ENTITY removal|nmod|END_ENTITY	Defective removal of cellular cholesterol and phospholipids by apolipoprotein_A-I in Tangier_Disease .
7693760	1	cholesterol	72,83	apolipoprotein_A-I	128,146	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	transport|compound|START_ENTITY A_defect|nmod|transport caused|nsubj|A_defect caused|nmod|gene gene|amod|END_ENTITY	A_defect in reverse cholesterol transport caused by a point mutation in the apolipoprotein_A-I gene .
7721760	0	cholesterol	30,41	apolipoprotein_A-I	8,26	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	transfer|compound|START_ENTITY Role|nmod|transfer Role|nmod|END_ENTITY	Role of apolipoprotein_A-I in cholesterol transfer between lipoproteins .
7929849	0	cholesterol	90,101	apolipoprotein_A-I	50,68	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	clearing|dobj|START_ENTITY END_ENTITY|advcl|clearing	Synthetic amphipathic helical peptides that mimic apolipoprotein_A-I in clearing cellular cholesterol .
7998758	0	cholesterol	69,80	apolipoprotein_A-I	25,43	cholesterol	apolipoprotein A-I	MESH:D002784	11806(Tax:10090)	Chemical	Gene	-RSB-|compound|START_ENTITY transport|nmod|-RSB- transport|compound|END_ENTITY	-LSB- Lipoproteins containing apolipoprotein_A-I and reverse transport of cholesterol -RSB- .
8087941	0	cholesterol	137,148	apolipoprotein_A-I	54,72	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	circulating|dobj|START_ENTITY increases|xcomp|circulating increases|nsubj|transfer transfer|nmod|gene gene|acl|encoding encoding|dobj|END_ENTITY	Adenovirus-mediated transfer of a gene encoding human apolipoprotein_A-I into normal mice increases circulating high-density lipoprotein cholesterol .
8226847	0	cholesterol	10,21	apolipoprotein_A-I	53,71	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|charge charge|nmod|END_ENTITY	Effect of cholesterol on the charge and structure of apolipoprotein_A-I in recombinant high density lipoprotein particles .
8473514	0	cholesterol	139,150	apolipoprotein_A-I	64,82	cholesterol	apolipoprotein A-I	MESH:D002784	100009253(Tax:9986)	Chemical	Gene	levels|nmod|START_ENTITY subjects|nmod|levels END_ENTITY|nmod|subjects	Increased plasma and renal clearance of an exchangeable pool of apolipoprotein_A-I in subjects with low levels of high density lipoprotein cholesterol .
8529997	0	cholesterol	119,130	apolipoprotein_A-I	41,59	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	determinant|nmod|START_ENTITY promoter|nmod|determinant promoter|amod|END_ENTITY	Evaluation of G-to-A substitution in the apolipoprotein_A-I gene promoter as a determinant of high-density lipoprotein cholesterol level in subjects with and without cholesteryl_ester_transfer_protein deficiency .
8555173	0	cholesterol	95,106	apolipoprotein_A-I	32,50	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	efflux|nmod|START_ENTITY associated|nmod|efflux associated|nsubj|Identification Identification|nmod|sequence sequence|nmod|END_ENTITY	Identification of a sequence of apolipoprotein_A-I associated with the efflux of intracellular cholesterol to human serum and apolipoprotein_A-I containing particles .
8558077	0	cholesterol	47,58	apolipoprotein_A-I	116,134	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	intracellular|nmod|START_ENTITY Efflux|nmod|intracellular Efflux|dep|availability availability|nmod|END_ENTITY	Efflux of intracellular versus plasma membrane cholesterol in HepG2 cells : different availability and regulation by apolipoprotein_A-I .
8590755	0	cholesterol	41,52	apolipoprotein_A-I	120,138	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	interaction|compound|START_ENTITY mechanism|nmod|interaction study|nmod|mechanism study|dep|model model|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Spectroscopic study of the mechanism of cholesterol interaction with apolipoproteins : a model of cholesterol-synthetic apolipoprotein_A-I fragment -RSB- .
8798380	0	cholesterol	149,160	apolipoprotein_A-I	66,84	cholesterol	apolipoprotein A-I	MESH:D002784	11806(Tax:10090)	Chemical	Gene	stores|compound|START_ENTITY depletion|nmod|stores up-regulated|nmod|depletion up-regulated|nmod|gland gland|nmod|mice mice|amod|END_ENTITY	Scavenger_receptor_BI -LRB- SR-BI -RRB- is up-regulated in adrenal gland in apolipoprotein_A-I and hepatic_lipase knock-out mice as a response to depletion of cholesterol stores .
8810270	0	cholesterol	69,80	apolipoprotein_A-I	39,57	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	efflux|compound|START_ENTITY stimulates|dobj|efflux stimulates|nsubj|association association|nmod|END_ENTITY	Specific phospholipid association with apolipoprotein_A-I stimulates cholesterol efflux from human fibroblasts .
8840853	0	cholesterol	159,170	apolipoprotein_A-I	41,59	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	absence|nmod|START_ENTITY patients|nmod|absence allele|nmod|patients allele|nsubj|heterozygosity heterozygosity|nmod|variant variant|compound|END_ENTITY	Compound heterozygosity for a structural apolipoprotein_A-I variant , apo_A-I -LRB- L141R -RRB- Pisa , and an apolipoprotein_A-I null allele in patients with absence of HDL cholesterol , corneal opacifications , and coronary_heart_disease .
8969186	0	cholesterol	19,30	apolipoprotein_A-I	51,69	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	Efflux|nmod|START_ENTITY Efflux|nmod|mutants mutants|amod|END_ENTITY	Efflux of cellular cholesterol and phospholipid to apolipoprotein_A-I mutants .
8987984	0	cholesterol	97,108	apolipoprotein_A-I	14,32	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	efflux|compound|START_ENTITY HDL|nmod|efflux HDL|nsubj|Effect Effect|nmod|END_ENTITY	Effect of the apolipoprotein_A-I and surface lipid composition of reconstituted discoidal HDL on cholesterol efflux from cultured fibroblasts .
9034206	0	cholesterol	107,118	apolipoprotein_A-I	19,37	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	levels|nmod|START_ENTITY associated|nmod|levels associated|nsubjpass|Heterozygosity Heterozygosity|nmod|Oslo Oslo|compound|END_ENTITY	Heterozygosity for apolipoprotein_A-I -LRB- R160L -RRB- Oslo is associated with low levels of high density lipoprotein cholesterol and HDL-subclass LpA-I/A-II but normal levels of HDL-subclass LpA-I .
9047326	0	cholesterol	257,268	apolipoprotein_A-I	119,137	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	transport|compound|START_ENTITY effective|nmod|transport transgenic_mice|dep|effective efflux|parataxis|transgenic_mice efflux|nmod|END_ENTITY	Cholesterol efflux , lecithin-cholesterol_acyltransferase activity , and pre-beta particle formation by serum from human apolipoprotein_A-I and apolipoprotein_A-I / apolipoprotein_A-II transgenic_mice consistent with the latter being less effective for reverse cholesterol transport .
9125178	0	cholesterol	23,34	apolipoprotein_A-I	73,91	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	Activation|nmod|START_ENTITY acyltransferase|nsubj|Activation acyltransferase|nmod|dimer dimer|compound|END_ENTITY	Activation of lecithin cholesterol acyltransferase by a disulfide-linked apolipoprotein_A-I dimer .
9327755	0	cholesterol	35,46	apolipoprotein_A-I	13,31	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	efflux|compound|START_ENTITY Role|nmod|efflux Role|nmod|END_ENTITY	Role of free apolipoprotein_A-I in cholesterol efflux .
9327756	0	cholesterol	125,136	apolipoprotein_A-I	85,103	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	recruit|dobj|START_ENTITY reduced|advcl|recruit reduced|dobj|capacity capacity|nmod|END_ENTITY	Evidence that apolipoprotein_A-IMilano has reduced capacity , compared with wild-type apolipoprotein_A-I , to recruit membrane cholesterol .
9351366	0	cholesterol	32,43	apolipoprotein_A-I	91,109	cholesterol	apolipoprotein A-I	MESH:D002784	11806(Tax:10090)	Chemical	Gene	efflux|compound|START_ENTITY Effects|nmod|efflux Effects|nmod|normal normal|dep|END_ENTITY	Effects of genotype and diet on cholesterol efflux into plasma and lipoproteins of normal , apolipoprotein_A-I - , and apolipoprotein_E-deficient mice .
9622280	0	cholesterol	90,101	apolipoprotein_A-I	6,24	cholesterol	apolipoprotein A-I	MESH:D002784	335	Chemical	Gene	response|compound|START_ENTITY plasma|dobj|response influences|xcomp|plasma influences|nsubj|mutation mutation|compound|END_ENTITY	Human apolipoprotein_A-I gene promoter mutation influences plasma low density lipoprotein cholesterol response to dietary fat saturation .
11701467	0	cholesterol	10,21	apolipoprotein_AI	32,49	cholesterol	apolipoprotein AI	MESH:D002784	11806(Tax:10090)	Chemical	Gene	efflux|compound|START_ENTITY efflux|nmod|END_ENTITY	Increased cholesterol efflux in apolipoprotein_AI -LRB- ApoAI -RRB- - producing macrophages as a mechanism for reduced atherosclerosis in ApoAI -LRB- -LRB- - / - -RRB- -RRB- mice .
21306749	0	cholesterol	24,35	apolipoprotein_B	39,55	cholesterol	apolipoprotein B	MESH:D002784	338	Chemical	Gene	START_ENTITY|nmod|ratio ratio|amod|END_ENTITY	Low-density lipoprotein cholesterol to apolipoprotein_B ratio is independently associated with metabolic_syndrome in Korean men .
17647040	0	cholesterol	19,30	apolipoprotein_B-100	77,97	cholesterol	apolipoprotein B-100	MESH:D002784	238055(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of dietary cholesterol on tissue ceramides and oxidation products of apolipoprotein_B-100 in ApoE-deficient mice .
22906437	0	cholesterol	9,20	apolipoprotein_B-100	77,97	cholesterol	apolipoprotein B-100	MESH:D002784	338	Chemical	Gene	protein|compound|START_ENTITY ORP10|appos|protein regulates|nsubj|ORP10 regulates|dobj|secretion secretion|amod|END_ENTITY	ORP10 , a cholesterol binding protein associated with microtubules , regulates apolipoprotein_B-100 secretion .
7637647	0	cholesterol	27,38	apolipoprotein_B-100	74,94	cholesterol	apolipoprotein B-100	MESH:D002784	338	Chemical	Gene	synthesis|compound|START_ENTITY correlation|nmod|synthesis correlation|nmod|END_ENTITY	Direct correlation between cholesterol synthesis and hepatic secretion of apolipoprotein_B-100 in normolipidemic subjects .
19200542	0	cholesterol	108,119	apolipoprotein_B-48	64,83	cholesterol	apolipoprotein B-48	MESH:D002784	338	Chemical	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	Effects of intensive atorvastatin and rosuvastatin treatment on apolipoprotein_B-48 and remnant lipoprotein cholesterol levels .
10484608	0	cholesterol	27,38	apolipoprotein_E	135,151	cholesterol	apolipoprotein E	MESH:D002784	348	Chemical	Gene	efflux|compound|START_ENTITY efflux|dep|study study|nmod|endogenous endogenous|nmod|END_ENTITY	Apolipoprotein_E-dependent cholesterol efflux from macrophages : kinetic study and divergent mechanisms for endogenous versus exogenous apolipoprotein_E .
10532681	0	cholesterol	103,114	apolipoprotein_E	33,49	cholesterol	apolipoprotein E	MESH:D002784	11816(Tax:10090)	Chemical	Gene	biosynthesis|compound|START_ENTITY associated|nmod|biosynthesis associated|nsubjpass|atherogenicity atherogenicity|nmod|mice mice|amod|END_ENTITY	Angiotensin_II atherogenicity in apolipoprotein_E deficient mice is associated with increased cellular cholesterol biosynthesis .
10601643	0	cholesterol	116,127	apolipoprotein_E	61,77	cholesterol	apolipoprotein E	MESH:D002784	25728(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY expression|dep|role expression|compound|END_ENTITY	Dietary and hypothyroid_hypercholesterolemia induces hepatic apolipoprotein_E expression in the rat : direct role of cholesterol .
10725355	0	cholesterol	35,46	apolipoprotein_E	112,128	cholesterol	apolipoprotein E	MESH:D002784	11816(Tax:10090)	Chemical	Gene	absorption|compound|START_ENTITY absorption|dep|studies studies|nmod|mice mice|amod|END_ENTITY	Apolipoprotein_E regulates dietary cholesterol absorption and biliary cholesterol excretion : studies in C57BL/6 apolipoprotein_E knockout mice .
10933584	0	cholesterol	38,49	apolipoprotein_E	11,27	cholesterol	apolipoprotein E	MESH:D002784	11816(Tax:10090)	Chemical	Gene	efflux|compound|START_ENTITY mediated|nsubj|efflux modulates|ccomp|mediated modulates|advmod|END_ENTITY	Endogenous apolipoprotein_E modulates cholesterol efflux and cholesteryl_ester hydrolysis mediated by high-density_lipoprotein-3 and lipid-free apolipoproteins in mouse peritoneal macrophages .
10933930	0	cholesterol	96,107	apolipoprotein_E	22,38	cholesterol	apolipoprotein E	MESH:D002784	11816(Tax:10090)	Chemical	Gene	levels|compound|START_ENTITY reducing|dobj|levels inhibits|advcl|reducing inhibits|nsubj|expression expression|nmod|END_ENTITY	Hepatic expression of apolipoprotein_E inhibits progression of atherosclerosis without reducing cholesterol levels in LDL_receptor-deficient mice .
11177205	0	cholesterol	126,137	apolipoprotein_E	141,157	cholesterol	apolipoprotein E	MESH:D002784	348	Chemical	Gene	START_ENTITY|nmod|individuals individuals|amod|END_ENTITY	Gene-nutrient interactions : dietary behaviour associated with high coronary_heart_disease risk particularly affects serum LDL cholesterol in apolipoprotein_E epsilon4-carrying free-living individuals .
12077730	0	cholesterol	92,103	apolipoprotein_E	11,27	cholesterol	apolipoprotein E	MESH:D002784	348	Chemical	Gene	changes|nmod|START_ENTITY genotype|nmod|changes genotype|nsubj|Effects Effects|nmod|END_ENTITY	Effects of apolipoprotein_E genotype on dietary-induced changes in high-density lipoprotein cholesterol in obese postmenopausal women .
12588770	0	cholesterol	18,29	apolipoprotein_E	57,73	cholesterol	apolipoprotein E	MESH:D002784	11816(Tax:10090)	Chemical	Gene	efflux|compound|START_ENTITY efflux|nmod|macrophages macrophages|nmod|END_ENTITY	Isoform-dependent cholesterol efflux from macrophages by apolipoprotein_E is modulated by cell surface proteoglycans .
12821037	0	cholesterol	55,66	apolipoprotein_E	35,51	cholesterol	apolipoprotein E	MESH:D002784	348	Chemical	Gene	patients|compound|START_ENTITY END_ENTITY|nmod|patients	Biliary pronucleating proteins and apolipoprotein_E in cholesterol and pigment stone patients .
14501024	0	cholesterol	96,107	apolipoprotein_E	11,27	cholesterol	apolipoprotein E	MESH:D002784	11816(Tax:10090)	Chemical	Gene	modulation|nmod|START_ENTITY Changes|nmod|modulation Changes|nmod|expression expression|amod|END_ENTITY	Changes in apolipoprotein_E expression in response to dietary and pharmacological modulation of cholesterol .
15066991	0	cholesterol	98,109	apolipoprotein_E	30,46	cholesterol	apolipoprotein E	MESH:D002784	348	Chemical	Gene	efflux|compound|START_ENTITY independent|nmod|efflux independent|nsubj|secretion secretion|compound|END_ENTITY	Apolipoprotein_A-I-stimulated apolipoprotein_E secretion from human macrophages is independent of cholesterol efflux .
15186962	0	cholesterol	16,27	apolipoprotein_E	66,82	cholesterol	apolipoprotein E	MESH:D002784	348	Chemical	Gene	increase|nmod|START_ENTITY associated|nsubjpass|increase associated|nmod|genotype genotype|amod|END_ENTITY	The increase in cholesterol with menopause is associated with the apolipoprotein_E genotype .
15450674	0	cholesterol	16,27	apolipoprotein_E	47,63	cholesterol	apolipoprotein E	MESH:D002784	11816(Tax:10090)	Chemical	Gene	diet|compound|START_ENTITY Effects|nmod|diet Effects|nmod|gliosis gliosis|nmod|mice mice|amod|END_ENTITY	Effects of high cholesterol diet on gliosis in apolipoprotein_E knockout mice .
16092050	0	cholesterol	129,140	apolipoprotein_E	13,29	cholesterol	apolipoprotein E	MESH:D002784	348	Chemical	Gene	concentrations|compound|START_ENTITY estimation|nmod|concentrations genotype|nmod|estimation genotype|nsubj|Influence Influence|nmod|END_ENTITY	Influence of apolipoprotein_E genotype on the reliability of the Friedewald formula in the estimation of low-density lipoprotein cholesterol concentrations .
16115471	0	cholesterol	8,19	apolipoprotein_E	111,127	cholesterol	apolipoprotein E	MESH:D002784	11816(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|xcomp|delay delay|dobj|development development|nmod|atherosclerotic_lesions atherosclerotic_lesions|nmod|mice mice|amod|END_ENTITY	Dietary cholesterol suppresses the ability of olive oil to delay the development of atherosclerotic_lesions in apolipoprotein_E knockout mice .
16198427	0	cholesterol	5,16	apolipoprotein_E	101,117	cholesterol	apolipoprotein E	MESH:D002784	11816(Tax:10090)	Chemical	Gene	results|compound|START_ENTITY results|nmod|knockout knockout|amod|END_ENTITY	High cholesterol diet results in increased expression of interleukin-6 and caspase-1 in the brain of apolipoprotein_E knockout and wild_type mice .
16288750	0	cholesterol	5,16	apolipoprotein_E	58,74	cholesterol	apolipoprotein E	MESH:D002784	11816(Tax:10090)	Chemical	Gene	diet|compound|START_ENTITY induces|nsubj|diet induces|dobj|hyperphosphorylation hyperphosphorylation|nmod|mice mice|amod|END_ENTITY	High cholesterol diet induces tau hyperphosphorylation in apolipoprotein_E deficient mice .
16866904	0	cholesterol	12,23	apolipoprotein_E	32,48	cholesterol	apolipoprotein E	MESH:D002784	348	Chemical	Gene	levels|compound|START_ENTITY Circulating|dobj|levels influence|advcl|Circulating influence|nsubj|genotype genotype|amod|END_ENTITY	Circulating cholesterol levels , apolipoprotein_E genotype and dementia severity influence the benefit of atorvastatin treatment in Alzheimer 's _ disease : results of the Alzheimer 's _ Disease Cholesterol-Lowering Treatment -LRB- ADCLT -RRB- trial .
17121837	0	cholesterol	50,61	apolipoprotein_E	72,88	cholesterol	apolipoprotein E	MESH:D002784	348	Chemical	Gene	efflux|compound|START_ENTITY efflux|nmod|discs discs|amod|END_ENTITY	Role of ABCG1 and ABCA1 in regulation of neuronal cholesterol efflux to apolipoprotein_E discs and suppression of amyloid-beta peptide generation .
17305370	0	cholesterol	106,117	apolipoprotein_E	39,55	cholesterol	apolipoprotein E	MESH:D002784	348	Chemical	Gene	efflux|compound|START_ENTITY mediator|nmod|efflux mediator|nsubj|domain domain|nmod|END_ENTITY	The C-terminal lipid-binding domain of apolipoprotein_E is a highly efficient mediator of ABCA1-dependent cholesterol efflux that promotes the assembly of high-density lipoproteins .
17504523	0	cholesterol	100,111	apolipoprotein_E	16,32	cholesterol	apolipoprotein E	MESH:D002784	348	Chemical	Gene	release|compound|START_ENTITY inhibits|dobj|release inhibits|nsubj|action action|nmod|END_ENTITY	Novel action of apolipoprotein_E -LRB- ApoE -RRB- : ApoE isoform specifically inhibits lipid-particle-mediated cholesterol release from neurons .
18279555	0	cholesterol	19,30	apolipoprotein_E	95,111	cholesterol	apolipoprotein E	MESH:D002784	348	Chemical	Gene	Effects|nmod|START_ENTITY sterols|nsubj|Effects sterols|nmod|subgroups subgroups|compound|END_ENTITY	Effects of dietary cholesterol and fat on serum non-cholesterol sterols according to different apolipoprotein_E subgroups among healthy men .
18359298	0	cholesterol	53,64	apolipoprotein_E	13,29	cholesterol	apolipoprotein E	MESH:D002784	11816(Tax:10090)	Chemical	Gene	efflux|compound|START_ENTITY associated|nmod|efflux associated|nsubjpass|Recycling Recycling|nmod|END_ENTITY	Recycling of apolipoprotein_E is not associated with cholesterol efflux in neuronal cells .
1892898	0	cholesterol	86,97	apolipoprotein_E	62,78	cholesterol	apolipoprotein E	MESH:D002784	25728(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY cultures|nmod|uptake plasma|nmod|cultures plasma|nmod|END_ENTITY	Effect of rat plasma high density lipoprotein with or without apolipoprotein_E on the cholesterol uptake and on the induction of the corticosteroid biosynthetic pathway in newborn rat adrenocortical cell cultures .
19239128	0	cholesterol	8,19	apolipoprotein_E	62,78	cholesterol	apolipoprotein E	MESH:D002784	11816(Tax:10090)	Chemical	Gene	administration|compound|START_ENTITY elevate|nsubj|administration elevate|dobj|END_ENTITY	Dietary cholesterol and estrogen administration elevate brain apolipoprotein_E in mice by different mechanisms .
19457062	0	cholesterol	50,61	apolipoprotein_E	18,34	cholesterol	apolipoprotein E	MESH:D002784	348	Chemical	Gene	esterification|compound|START_ENTITY esterification|amod|END_ENTITY	Haptoglobin binds apolipoprotein_E and influences cholesterol esterification in the cerebrospinal fluid .
19524160	0	cholesterol	46,57	apolipoprotein_E	11,27	cholesterol	apolipoprotein E	MESH:D002784	348	Chemical	Gene	genotype|nmod|START_ENTITY genotype|nsubj|Effects Effects|nmod|END_ENTITY	Effects of apolipoprotein_E genotype on blood cholesterol in adolescent girls .
20206948	0	cholesterol	133,144	apolipoprotein_E	10,26	cholesterol	apolipoprotein E	MESH:D002784	348	Chemical	Gene	associate|nmod|START_ENTITY mean|dobj|associate mean|nsubj|level level|amod|END_ENTITY	Increased apolipoprotein_E level and reduced high-density lipoprotein mean particle size associate with low high-density lipoprotein cholesterol and features of metabolic_syndrome .
20797970	0	cholesterol	88,99	apolipoprotein_E	50,66	cholesterol	apolipoprotein E	MESH:D002784	348	Chemical	Gene	homeostasis|compound|START_ENTITY END_ENTITY|dobj|homeostasis	Epitope-specific anti-prion antibodies upregulate apolipoprotein_E and disrupt membrane cholesterol homeostasis .
20966401	0	cholesterol	83,94	apolipoprotein_E	30,46	cholesterol	apolipoprotein E	MESH:D002784	11816(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY necessary|nmod|transport necessary|nsubj|END_ENTITY	Macrophage , but not systemic , apolipoprotein_E is necessary for macrophage reverse cholesterol transport in vivo .
21273563	0	cholesterol	130,141	apolipoprotein_E	76,92	cholesterol	apolipoprotein E	MESH:D002784	11816(Tax:10090)	Chemical	Gene	level|compound|START_ENTITY mice|nmod|level mice|amod|END_ENTITY	Histamine_deficiency decreases atherosclerosis and inflammatory response in apolipoprotein_E knockout mice independently of serum cholesterol level .
21605030	0	cholesterol	43,54	apolipoprotein_E	13,29	cholesterol	apolipoprotein E	MESH:D002784	348	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|compound|END_ENTITY	y-Secretase , apolipoprotein_E and cellular cholesterol metabolism .
21924378	0	cholesterol	69,80	apolipoprotein_E	126,142	cholesterol	apolipoprotein E	MESH:D002784	11816(Tax:10090)	Chemical	Gene	absorption|compound|START_ENTITY reduces|dobj|absorption reduces|nmod|mice mice|amod|END_ENTITY	Lack of acyl-CoA : diacylglycerol_acyltransferase 1 reduces intestinal cholesterol absorption and attenuates atherosclerosis in apolipoprotein_E knockout mice .
23159231	0	cholesterol	51,62	apolipoprotein_E	4,20	cholesterol	apolipoprotein E	MESH:D002784	11816(Tax:10090)	Chemical	Gene	peptides|nmod|START_ENTITY peptides|amod|END_ENTITY	Two apolipoprotein_E mimetic peptides with similar cholesterol reducing properties exhibit differential atheroprotective effects in LDL-R null mice .
2344296	2	cholesterol	148,159	apolipoprotein_E	98,114	cholesterol	apolipoprotein E	MESH:D002784	348	Chemical	Gene	prediction|nmod|START_ENTITY phenotype|nmod|prediction phenotype|nsubj|Contribution Contribution|nmod|END_ENTITY	Contribution of apolipoprotein_E phenotype to prediction of total cholesterol , apolipoprotein_B , and low density lipoprotein cholesterol in the healthy women study .
23684442	0	cholesterol	111,122	apolipoprotein_E	126,142	cholesterol	apolipoprotein E	MESH:D002784	11816(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Aronia melanocarpa -LRB- chokeberry -RRB- polyphenol-rich extract improves antioxidant function and reduces total plasma cholesterol in apolipoprotein_E knockout mice .
24710030	0	cholesterol	153,164	apolipoprotein_E	96,112	cholesterol	apolipoprotein E	MESH:D002784	11816(Tax:10090)	Chemical	Gene	diet|compound|START_ENTITY fed|dobj|diet mice|acl|fed /|dep|mice stiffness|amod|/ stiffness|nmod|END_ENTITY	Inhibition of glycosphingolipid_synthesis ameliorates atherosclerosis and arterial stiffness in apolipoprotein_E - / - mice and rabbits fed a high-fat and - cholesterol diet .
2493483	0	cholesterol	90,101	apolipoprotein_E	11,27	cholesterol	apolipoprotein E	MESH:D002784	25728(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY role|nmod|transport role|nmod|receptors receptors|amod|density density|dep|END_ENTITY	A role for apolipoprotein_E , apolipoprotein_A-I , and low density lipoprotein receptors in cholesterol transport during regeneration and remyelination of the rat sciatic nerve .
25325355	0	cholesterol	29,40	apolipoprotein_E	85,101	cholesterol	apolipoprotein E	MESH:D002784	348	Chemical	Gene	trajectories|nmod|START_ENTITY trajectories|nmod|status status|amod|END_ENTITY	Longitudinal trajectories of cholesterol from midlife through late life according to apolipoprotein_E allele status .
2911597	0	cholesterol	30,41	apolipoprotein_E	61,77	cholesterol	apolipoprotein E	MESH:D002784	100009337(Tax:9986)	Chemical	Gene	START_ENTITY|nmod|injection injection|nmod|END_ENTITY	Increased clearance of plasma cholesterol after injection of apolipoprotein_E into Watanabe_heritable_hyperlipidemic rabbits .
2924207	0	cholesterol	35,46	apolipoprotein_E	76,92	cholesterol	apolipoprotein E	MESH:D002784	348	Chemical	Gene	concentration|compound|START_ENTITY LDL|dobj|concentration LDL|xcomp|END_ENTITY	Hypertriglyceridemia and lower LDL cholesterol concentration in relation to apolipoprotein_E phenotypes in myotonic_dystrophy .
3624230	0	cholesterol	16,27	apolipoprotein_E	46,62	cholesterol	apolipoprotein E	MESH:D002784	11816(Tax:10090)	Chemical	Gene	content|compound|START_ENTITY regulates|nsubj|content regulates|dobj|synthesis synthesis|amod|END_ENTITY	Macrophage free cholesterol content regulates apolipoprotein_E synthesis .
3688836	2	cholesterol	225,236	apolipoprotein_E	159,175	cholesterol	apolipoprotein E	MESH:D002784	348	Chemical	Gene	levels|compound|START_ENTITY estimation|nmod|levels estimation|nmod|frequencies frequencies|nmod|polymorphism polymorphism|amod|END_ENTITY	Simultaneous estimation of the frequencies and effects of the apolipoprotein_E polymorphism and residual polygenetic effects on cholesterol , betalipoprotein and triglyceride levels .
6743379	0	cholesterol	18,29	apolipoprotein_E	33,49	cholesterol	apolipoprotein E	MESH:D002784	100009337(Tax:9986)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|synthesis synthesis|amod|END_ENTITY	Effect of dietary cholesterol on apolipoprotein_E synthesis in the rabbit .
7783869	0	cholesterol	49,60	apolipoprotein_E	16,32	cholesterol	apolipoprotein E	MESH:D002784	348	Chemical	Gene	level|dep|START_ENTITY level|dep|Interactions Interactions|nmod|END_ENTITY	Interactions of apolipoprotein_E genotype , total cholesterol level , age , and sex in prediction of Alzheimer 's _ disease : a case-control study .
7783962	0	cholesterol	118,129	apolipoprotein_E	30,46	cholesterol	apolipoprotein E	MESH:D002784	100009337(Tax:9986)	Chemical	Gene	administration|nmod|START_ENTITY neurons|nmod|administration neurons|nsubj|density density|nmod|immunoreactive immunoreactive|compound|END_ENTITY	Increased density of cortical apolipoprotein_E immunoreactive neurons in rabbit brain after dietary administration of cholesterol .
7802634	0	cholesterol	41,52	apolipoprotein_E	12,28	cholesterol	apolipoprotein E	MESH:D002784	11816(Tax:10090)	Chemical	Gene	efflux|compound|START_ENTITY END_ENTITY|nmod|efflux	Role of HDL apolipoprotein_E in cellular cholesterol efflux : studies in apo_E knockout transgenic_mice .
7813899	0	cholesterol	50,61	apolipoprotein_E	138,154	cholesterol	apolipoprotein E	MESH:D002784	348	Chemical	Gene	change|nmod|START_ENTITY change|dep|effects effects|amod|END_ENTITY	Genetic influences on age-related change in total cholesterol , low density lipoprotein-cholesterol , and triglyceride levels : longitudinal apolipoprotein_E genotype effects .
7868975	0	cholesterol	96,107	apolipoprotein_E	10,26	cholesterol	apolipoprotein E	MESH:D002784	348	Chemical	Gene	lowering|nmod|START_ENTITY phenotype|nmod|lowering phenotype|nsubj|Effect Effect|nmod|END_ENTITY	Effect of apolipoprotein_E phenotype on diet-induced lowering of plasma low density lipoprotein cholesterol .
7989859	0	cholesterol	79,90	apolipoprotein_E	33,49	cholesterol	apolipoprotein E	MESH:D002784	348	Chemical	Gene	efflux|compound|START_ENTITY enhances|dobj|efflux enhances|nsubj|Expression Expression|nmod|END_ENTITY	Expression of heterologous human apolipoprotein_E by J774 macrophages enhances cholesterol efflux to HDL3 .
8345812	0	cholesterol	12,23	apolipoprotein_E	79,95	cholesterol	apolipoprotein E	MESH:D002784	348	Chemical	Gene	Response|nmod|START_ENTITY synthesis|nsubj|Response synthesis|nmod|men men|nmod|genotypes genotypes|compound|END_ENTITY	Response of cholesterol synthesis to cholesterol feeding in men with different apolipoprotein_E genotypes .
8345812	0	cholesterol	37,48	apolipoprotein_E	79,95	cholesterol	apolipoprotein E	MESH:D002784	348	Chemical	Gene	feeding|compound|START_ENTITY synthesis|nmod|feeding synthesis|nmod|men men|nmod|genotypes genotypes|compound|END_ENTITY	Response of cholesterol synthesis to cholesterol feeding in men with different apolipoprotein_E genotypes .
8457259	0	cholesterol	90,101	apolipoprotein_E	10,26	cholesterol	apolipoprotein E	MESH:D002784	348	Chemical	Gene	variation|nmod|START_ENTITY determining|dobj|variation polymorphism|advcl|determining polymorphism|nsubj|Impact Impact|nmod|END_ENTITY	Impact of apolipoprotein_E polymorphism in determining interindividual variation in total cholesterol and low density lipoprotein cholesterol in Hispanics and non-Hispanic whites .
8468527	0	cholesterol	77,88	apolipoprotein_E	121,137	cholesterol	apolipoprotein E	MESH:D002784	348	Chemical	Gene	feeding|compound|START_ENTITY protein|nmod|feeding protein|dep|relationship relationship|acl|END_ENTITY	Cholesteryl_ester transfer protein and high density lipoprotein responses to cholesterol feeding in men : relationship to apolipoprotein_E genotype .
8500739	0	cholesterol	10,21	apolipoprotein_E	44,60	cholesterol	apolipoprotein E	MESH:D002784	348	Chemical	Gene	content|compound|START_ENTITY related|nsubjpass|content related|xcomp|END_ENTITY	Gallstone cholesterol content is related to apolipoprotein_E polymorphism .
8675636	0	cholesterol	84,95	apolipoprotein_E	15,31	cholesterol	apolipoprotein E	MESH:D002784	348	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|polymorphism polymorphism|amod|END_ENTITY	Effects of the apolipoprotein_E polymorphism on uptake and transfer of cell-derived cholesterol in plasma .
9279519	0	cholesterol	47,58	apolipoprotein_E	11,27	cholesterol	apolipoprotein E	MESH:D002784	348	Chemical	Gene	level|compound|START_ENTITY phenotype|nmod|level phenotype|nsubj|Effects Effects|nmod|END_ENTITY	Effects of apolipoprotein_E phenotype on serum cholesterol level and cholesterol response to diet therapy in patients with hypercholesterolemia .
9505278	0	cholesterol	75,86	apolipoprotein_E	4,20	cholesterol	apolipoprotein E	MESH:D002784	348	Chemical	Gene	tracking|nmod|START_ENTITY influence|nmod|tracking has|dobj|influence has|nsubj|phenotype phenotype|amod|END_ENTITY	The apolipoprotein_E phenotype has a strong influence on tracking of serum cholesterol and lipoprotein levels in children : a follow-up study from birth to the age of 11 years .
9549720	0	cholesterol	12,23	apolipoprotein_E	25,41	cholesterol	apolipoprotein E	MESH:D002784	348	Chemical	Gene	START_ENTITY|appos|epsilon epsilon|amod|END_ENTITY	Serum total cholesterol , apolipoprotein_E epsilon 4 allele , and Alzheimer 's _ disease .
9636193	0	cholesterol	82,93	apolipoprotein_E	31,47	cholesterol	apolipoprotein E	MESH:D002784	348	Chemical	Gene	capacity|compound|START_ENTITY restores|dobj|capacity restores|nsubj|expression expression|nmod|transgene transgene|compound|END_ENTITY	Low-dose expression of a human apolipoprotein_E transgene in macrophages restores cholesterol efflux capacity of apolipoprotein_E-deficient mouse plasma .
9846849	0	cholesterol	120,131	apolipoprotein_E	10,26	cholesterol	apolipoprotein E	MESH:D002784	348	Chemical	Gene	modification|nmod|START_ENTITY polymorphism|nmod|modification polymorphism|nsubj|Effect Effect|nmod|END_ENTITY	Effect of apolipoprotein_E polymorphism on serum lipid response to the separate modification of dietary fat and dietary cholesterol .
16888319	0	cholesterol	119,130	apolipoprotein_E2	21,38	cholesterol	apolipoprotein E2	MESH:D002784	348	Chemical	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|effect effect|nmod|END_ENTITY	Protective effect of apolipoprotein_E2 on coronary_artery_disease in African Americans is mediated through lipoprotein cholesterol .
24407029	0	cholesterol	77,88	apolipoprotein_a-I	47,65	cholesterol	apolipoprotein a-I	MESH:D002784	335	Chemical	Gene	transport|compound|START_ENTITY Effects|nmod|transport Effects|nmod|END_ENTITY	Effects of native and myeloperoxidase-modified apolipoprotein_a-I on reverse cholesterol transport and atherosclerosis in mice .
25030535	0	cholesterol	37,48	apolipoprotein_a-I	49,67	cholesterol	apolipoprotein a-I	MESH:D002784	335	Chemical	Gene	Relation|nmod|START_ENTITY Relation|dep|ratio ratio|compound|END_ENTITY	Relation of high-density lipoprotein cholesterol : apolipoprotein_a-I ratio to progression of coronary_atherosclerosis in statin-treated patients .
2498030	0	cholesterol	172,183	apolipoproteins_A-1_and_B	50,75	cholesterol	apolipoproteins A-1 and B	MESH:D002784	101841336	Chemical	Gene	Isolation|nmod|START_ENTITY Isolation|nmod|END_ENTITY	Isolation , characterization and quantification of apolipoproteins_A-1_and_B of the Golden Syrian_hamster -LRB- Mesocricetus_auratus -RRB- and modification of their levels by dietary cholesterol .
9743230	0	cholesterol	43,54	apolipoproteins_A-I_and_A-II	6,34	cholesterol	apolipoproteins A-I and A-II	MESH:D002784	11847(Tax:10090)	Chemical	Gene	efflux|compound|START_ENTITY END_ENTITY|nmod|efflux	Human apolipoproteins_A-I_and_A-II in cell cholesterol efflux : studies with transgenic_mice .
1468123	0	cholesterol	20,31	apolipoproteins_A-I_and_E	49,74	cholesterol	apolipoproteins A-I and E	MESH:D002784	335	Chemical	Gene	interaction|compound|START_ENTITY interaction|nmod|END_ENTITY	On the mechanism of cholesterol interaction with apolipoproteins_A-I_and_E .
3922383	0	cholesterol	16,27	apoprotein_A-I	29,43	cholesterol	apoprotein A-I	MESH:D002784	335	Chemical	Gene	Response|nmod|START_ENTITY END_ENTITY|nsubj|Response	Response of HDL cholesterol , apoprotein_A-I , and LCAT to exercise withdrawal .
16192269	0	cholesterol	130,141	beta1-syntrophin	110,126	cholesterol	beta1-syntrophin	MESH:D002784	6641	Chemical	Gene	efflux|compound|START_ENTITY END_ENTITY|nmod|efflux	Purification of ATP-binding_cassette_transporter_A1 and associated binding proteins reveals the importance of beta1-syntrophin in cholesterol efflux .
12357044	0	cholesterol	40,51	bile_salt-stimulated_lipase	5,32	cholesterol	bile salt-stimulated lipase	MESH:D002784	1056	Chemical	Gene	uptake|compound|START_ENTITY affect|dobj|uptake affect|nsubj|END_ENTITY	Does bile_salt-stimulated_lipase affect cholesterol uptake when bound to rat intestinal mucosa in vitro ?
15210959	0	cholesterol	61,72	cassette_transporters_G1_and_G4	12,43	cholesterol	cassette transporters G1 and G4	MESH:D002784	57827	Chemical	Gene	efflux|compound|START_ENTITY mediate|dobj|efflux mediate|nsubj|END_ENTITY	ATP-binding cassette_transporters_G1_and_G4 mediate cellular cholesterol efflux to high-density lipoproteins .
12269838	0	cholesterol	40,51	caveolin-1	17,27	cholesterol	caveolin-1	MESH:D002784	857	Chemical	Gene	Stabilization|nmod|START_ENTITY Stabilization|nmod|END_ENTITY	Stabilization of caveolin-1 by cellular cholesterol and scavenger_receptor_class_B_type_I .
14729661	0	cholesterol	34,45	caveolin-1	14,24	cholesterol	caveolin-1	MESH:D002784	857	Chemical	Gene	efflux|compound|START_ENTITY enhances|dobj|efflux enhances|nsubj|Expression Expression|nmod|END_ENTITY	Expression of caveolin-1 enhances cholesterol efflux in hepatic cells .
26626726	0	cholesterol	115,126	caveolin-1	104,114	cholesterol	caveolin-1	MESH:D002784	857	Chemical	Gene	homeostasis|compound|START_ENTITY homeostasis|amod|END_ENTITY	Promotion of human mesenchymal stem cell osteogenesis by PI3-kinase/Akt signaling , and the influence of caveolin-1 / cholesterol homeostasis .
6889889	0	cholesterol	113,124	cholesterol-7_alpha-hydroxylase	54,85	cholesterol	cholesterol-7 alpha-hydroxylase	MESH:D002784	1581	Chemical	Gene	microsomal|nmod|START_ENTITY microsomal|xcomp|END_ENTITY	Rate-limiting , diurnal activity of hepatic microsomal cholesterol-7_alpha-hydroxylase in pigeons with high serum cholesterol .
1708805	1	cholesterol	90,101	cholesterol_7_alpha-hydroxylase	140,171	cholesterol	cholesterol 7 alpha-hydroxylase	MESH:D002784	25428(Tax:10116)	Chemical	Gene	7-dehydrocholesterol|nmod|START_ENTITY conversion|nmod|7-dehydrocholesterol Inhibition|nmod|conversion associated|nsubjpass|Inhibition associated|nmod|down-regulation down-regulation|nmod|activity activity|amod|END_ENTITY	V. Inhibition of conversion of 7-dehydrocholesterol to cholesterol is associated with down-regulation of cholesterol_7_alpha-hydroxylase activity and inhibition of bile_acid synthesis .
1805095	0	cholesterol	159,170	cholesterol_7_alpha-hydroxylase	98,129	cholesterol	cholesterol 7 alpha-hydroxylase	MESH:D002784	25428(Tax:10116)	Chemical	Gene	acyltransferase|compound|START_ENTITY acyltransferase|amod|END_ENTITY	Effects of perturbations in hepatic free and esterified cholesterol pools on bile_acid synthesis , cholesterol_7_alpha-hydroxylase , HMG-CoA_reductase , acyl-CoA : cholesterol acyltransferase and cytosolic cholesteryl_ester hydrolase .
3382675	0	cholesterol	102,113	cholesterol_7_alpha-hydroxylase	66,97	cholesterol	cholesterol 7 alpha-hydroxylase	MESH:D002784	25428(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY effects|nmod|metabolism effects|appos|inhibitor inhibitor|nmod|END_ENTITY	The effects of 6-azacholest-4-en-3_beta-ol-7-one , an inhibitor of cholesterol_7_alpha-hydroxylase , on cholesterol metabolism and bile_acid synthesis in primary cultures of rat hepatocytes .
3572250	0	cholesterol	17,28	cholesterol_7_alpha-hydroxylase	78,109	cholesterol	cholesterol 7 alpha-hydroxylase	MESH:D002784	25428(Tax:10116)	Chemical	Gene	pool|nmod|START_ENTITY importance|nsubj|pool importance|nmod|regulation regulation|nmod|activity activity|amod|END_ENTITY	The pool of free cholesterol is not of major importance for regulation of the cholesterol_7_alpha-hydroxylase activity in rat liver microsomes .
7240978	1	cholesterol	157,168	cholesterol_7_alpha-hydroxylase	50,81	cholesterol	cholesterol 7 alpha-hydroxylase	MESH:D002784	25428(Tax:10116)	Chemical	Gene	absence|nmod|START_ENTITY preparations|nmod|absence microsomal|dobj|preparations microsomal|nsubj|Measurement Measurement|nmod|activity activity|amod|END_ENTITY	Measurement of cholesterol_7_alpha-hydroxylase activity in rat liver microsomal preparations in the absence of endogenous cholesterol .
7705775	0	cholesterol	36,47	cholesterol_7_alpha-hydroxylase	102,133	cholesterol	cholesterol 7 alpha-hydroxylase	MESH:D002784	1581	Chemical	Gene	metabolism|compound|START_ENTITY bezafibrate|nmod|metabolism Influence|nmod|bezafibrate Influence|dep|activity activity|nmod|END_ENTITY	Influence of bezafibrate on hepatic cholesterol metabolism in gallstone patients : reduced activity of cholesterol_7_alpha-hydroxylase .
8354958	0	cholesterol	18,29	cholesterol_7_alpha-hydroxylase	50,81	cholesterol	cholesterol 7 alpha-hydroxylase	MESH:D002784	13122(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|LDL_receptors LDL_receptors|amod|END_ENTITY	Effect of dietary cholesterol and taurocholate on cholesterol_7_alpha-hydroxylase and hepatic LDL_receptors in inbred mice .
9162751	0	cholesterol	58,69	cholesterol_7_alpha-hydroxylase	73,104	cholesterol	cholesterol 7 alpha-hydroxylase	MESH:D002784	13122(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Dietary fats modulate the regulatory potential of dietary cholesterol on cholesterol_7_alpha-hydroxylase gene expression .
9404645	0	cholesterol	133,144	cholesterol_7_alpha-hydroxylase	47,78	cholesterol	cholesterol 7 alpha-hydroxylase	MESH:D002784	13122(Tax:10090)	Chemical	Gene	reduction|nmod|START_ENTITY stimulate|dobj|reduction sufficient|xcomp|stimulate sufficient|nsubj|transfection transfection|nmod|liver liver|nmod|transgene transgene|amod|END_ENTITY	Partial transfection of liver with a synthetic cholesterol_7_alpha-hydroxylase transgene is sufficient to stimulate the reduction of cholesterol in the plasma of hypercholesterolemic mice .
9521095	0	cholesterol	105,116	cholesterol_7_alpha-hydroxylase	15,46	cholesterol	cholesterol 7 alpha-hydroxylase	MESH:D002784	448985(Tax:9823)	Chemical	Gene	selected|nmod|START_ENTITY selected|nsubj|Alleles Alleles|nmod|gene gene|amod|END_ENTITY	Alleles of the cholesterol_7_alpha-hydroxylase -LRB- CYP7 -RRB- gene in pigs selected for high or low plasma total cholesterol .
10547226	0	cholesterol	58,69	cholesterol_esterase	18,38	cholesterol	cholesterol esterase	MESH:D002784	1056	Chemical	Gene	absorption|compound|START_ENTITY CVT-1|nmod|absorption CVT-1|amod|END_ENTITY	Lack of effect of cholesterol_esterase inhibitor CVT-1 on cholesterol absorption and LDL cholesterol in humans .
12074697	0	cholesterol	23,34	cholesterol_esterase	47,67	cholesterol	cholesterol esterase	MESH:D002784	280748(Tax:9913)	Chemical	Gene	START_ENTITY|nmod|serum serum|nmod|END_ENTITY	Determination of total cholesterol in serum by cholesterol_esterase and cholesterol oxidase immobilized and co-immobilized on to arylamine glass .
16814618	0	cholesterol	15,26	cholesterol_esterase	58,78	cholesterol	cholesterol esterase	MESH:D002784	1056	Chemical	Gene	biosensor|compound|START_ENTITY Development|nmod|biosensor based|nsubj|Development based|nmod|END_ENTITY	Development of cholesterol biosensor based on immobilized cholesterol_esterase and cholesterol oxidase on oxygen electrode for the determination of total cholesterol in food samples .
16814618	0	cholesterol	154,165	cholesterol_esterase	58,78	cholesterol	cholesterol esterase	MESH:D002784	1056	Chemical	Gene	determination|nmod|START_ENTITY based|nmod|determination based|nmod|END_ENTITY	Development of cholesterol biosensor based on immobilized cholesterol_esterase and cholesterol oxidase on oxygen electrode for the determination of total cholesterol in food samples .
17386511	0	cholesterol	101,112	cholesterol_esterase	18,38	cholesterol	cholesterol esterase	MESH:D002784	1056	Chemical	Gene	biosensor|compound|START_ENTITY oxidase|nmod|biosensor oxidase|nsubj|Immobilization Immobilization|nmod|END_ENTITY	Immobilization of cholesterol_esterase and cholesterol oxidase onto sol-gel films for application to cholesterol biosensor .
17761252	0	cholesterol	112,123	cholesterol_esterase	27,47	cholesterol	cholesterol esterase	MESH:D002784	1056	Chemical	Gene	biosensor|compound|START_ENTITY oxidase|nmod|biosensor oxidase|nsubj|immobilization immobilization|nmod|END_ENTITY	Covalent immobilization of cholesterol_esterase and cholesterol oxidase on polyaniline films for application to cholesterol biosensor .
23143624	0	cholesterol	76,87	cholesterol_esterase	39,59	cholesterol	cholesterol esterase	MESH:D002784	280748(Tax:9913)	Chemical	Gene	assay|compound|START_ENTITY END_ENTITY|nmod|assay	Porcine pancreas : a superior source of cholesterol_esterase for total serum cholesterol assay by the enzymatic kinetic method .
2334723	0	cholesterol	120,131	cholesterol_esterase	86,106	cholesterol	cholesterol esterase	MESH:D002784	280748(Tax:9913)	Chemical	Gene	O-acyltransferase|compound|START_ENTITY O-acyltransferase|compound|END_ENTITY	12 - -LSB- -LRB- 5-iodo-4-azido-2-hydroxybenzoyl -RRB- amino -RSB- dodecanoic_acid : biological recognition by cholesterol_esterase and acyl-CoA : cholesterol O-acyltransferase .
26853742	0	cholesterol	42,53	cholesterol_esterase	76,96	cholesterol	cholesterol esterase	MESH:D002784	1056	Chemical	Gene	total|dobj|START_ENTITY total|nmod|nanoparticles nanoparticles|nmod|oxidase oxidase|compound|END_ENTITY	Amperometric determination of serum total cholesterol with nanoparticles of cholesterol_esterase and cholesterol oxidase .
6284134	0	cholesterol	58,69	cholesterol_esterase	22,42	cholesterol	cholesterol esterase	MESH:D002784	24254(Tax:10116)	Chemical	Gene	acyltransferase|compound|START_ENTITY Regulation|dep|acyltransferase Regulation|nmod|END_ENTITY	Regulation of neutral cholesterol_esterase and acyl-CoA : cholesterol acyltransferase in the rat adrenal gland .
6747463	0	cholesterol	90,101	cholesterol_esterase	49,69	cholesterol	cholesterol esterase	MESH:D002784	24254(Tax:10116)	Chemical	Gene	absorption|dep|START_ENTITY absorption|dep|role role|nmod|A A|amod|END_ENTITY	Cholesterol absorption in rat intestine : role of cholesterol_esterase and acyl coenzyme A : cholesterol acyltransferase .
7918615	0	cholesterol	40,51	cholesterol_esterase	10,30	cholesterol	cholesterol esterase	MESH:D002784	24254(Tax:10116)	Chemical	Gene	loading|compound|START_ENTITY level|nmod|loading level|amod|END_ENTITY	Increased cholesterol_esterase level by cholesterol loading of rat pancreatoma cells .
7920899	0	cholesterol	14,25	cholesterol_esterase	79,99	cholesterol	cholesterol esterase	MESH:D002784	1056	Chemical	Gene	metabolism|compound|START_ENTITY Regulation|nmod|metabolism Regulation|dep|studies studies|nmod|END_ENTITY	Regulation of cholesterol metabolism in adrenal cortex : comparative studies on cholesterol_esterase in human adrenal glands .
7951508	0	cholesterol	14,25	cholesterol_esterase	82,102	cholesterol	cholesterol esterase	MESH:D002784	24254(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY Regulation|nmod|metabolism Regulation|dep|effects effects|nmod|apoproteins apoproteins|nmod|END_ENTITY	Regulation of cholesterol metabolism in adrenal cortex : effects of apoproteins on cholesterol_esterase in rat adrenal glands .
8141184	0	cholesterol	18,29	cholesterol_esterase	48,68	cholesterol	cholesterol esterase	MESH:D002784	24254(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of dietary cholesterol on rat glomerular cholesterol_esterase .
8636157	0	cholesterol	28,39	cholesterol_esterase	54,74	cholesterol	cholesterol esterase	MESH:D002784	12613(Tax:10090)	Chemical	Gene	absorption|compound|START_ENTITY absorption|nmod|END_ENTITY	Dietary free and esterified cholesterol absorption in cholesterol_esterase -LRB- bile_salt-stimulated_lipase -RRB- gene-targeted mice .
7756263	0	cholesterol	82,93	cholesteryl_ester_hydrolase	28,55	cholesterol	cholesteryl ester hydrolase	MESH:D002784	1066	Chemical	Gene	uptake|nmod|START_ENTITY END_ENTITY|nmod|uptake	Role of bile_salt-dependent cholesteryl_ester_hydrolase in the uptake of micellar cholesterol by intestinal cells .
10393213	0	cholesterol	22,33	cholesteryl_ester_transfer_protein	80,114	cholesterol	cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	element|compound|START_ENTITY element|nmod|promoter promoter|nmod|gene gene|compound|END_ENTITY	Characterization of a cholesterol response element -LRB- CRE -RRB- in the promoter of the cholesteryl_ester_transfer_protein gene : functional role of the transcription factors SREBP-1a , -2 , and YY1 .
10779455	0	cholesterol	13,24	cholesteryl_ester_transfer_protein	124,158	cholesterol	cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	factor|nsubj|START_ENTITY factor|advcl|caused caused|nmod|mutation mutation|nmod|gene gene|compound|END_ENTITY	Elevated HDL cholesterol is a risk factor for ischemic_heart_disease in white women when caused by a common mutation in the cholesteryl_ester_transfer_protein gene .
10971787	0	cholesterol	104,115	cholesteryl_ester_transfer_protein	42,76	cholesterol	cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	raises|nmod|START_ENTITY raises|dobj|levels levels|amod|END_ENTITY	Consumption of French-press coffee raises cholesteryl_ester_transfer_protein activity levels before LDL cholesterol in normolipidaemic subjects .
11025251	0	cholesterol	25,36	cholesteryl_ester_transfer_protein	115,149	cholesterol	cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	esterification|compound|START_ENTITY esterification|nmod|lipoproteins lipoproteins|acl|mediated mediated|nmod|END_ENTITY	High-density lipoprotein cholesterol esterification and transfer rates to lighter density lipoproteins mediated by cholesteryl_ester_transfer_protein in the fasting and postprandial periods are not altered in type_1_diabetes_mellitus .
11454014	0	cholesterol	105,116	cholesteryl_ester_transfer_protein	17,51	cholesterol	cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	levels|compound|START_ENTITY lipoproteins|dep|levels lipoproteins|amod|Variation Variation|nmod|gene gene|compound|END_ENTITY	Variation at the cholesteryl_ester_transfer_protein gene in relation to plasma high density lipoproteins cholesterol levels and carotid intima-media_thickness .
11689208	0	cholesterol	113,124	cholesteryl_ester_transfer_protein	14,48	cholesterol	cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	transport|compound|START_ENTITY Expression|nmod|transport Expression|nmod|END_ENTITY	Expression of cholesteryl_ester_transfer_protein in human atherosclerotic_lesions and its implication in reverse cholesterol transport .
11888509	0	cholesterol	123,134	cholesteryl_ester_transfer_protein	8,42	cholesterol	cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	levels|compound|START_ENTITY associated|nmod|levels associated|nsubj|polymorphism polymorphism|compound|END_ENTITY	A novel cholesteryl_ester_transfer_protein promoter polymorphism -LRB- -971 G/A -RRB- associated with plasma high-density lipoprotein cholesterol levels .
12164095	0	cholesterol	76,87	cholesteryl_ester_transfer_protein	21,55	cholesterol	cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	level|compound|START_ENTITY HDL|dobj|level HDL|nsubj|mutation mutation|nmod|gene gene|compound|END_ENTITY	A common mutation in cholesteryl_ester_transfer_protein gene and plasma HDL cholesterol level before and after hormone replacement therapy in Korean postmenopausal women .
12519369	0	cholesterol	97,108	cholesteryl_ester_transfer_protein	19,53	cholesterol	cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	polymorphism|nmod|START_ENTITY polymorphism|nsubj|association association|nmod|END_ENTITY	The association of cholesteryl_ester_transfer_protein polymorphism with high-density lipoprotein cholesterol and coronary_artery_disease in Koreans .
12771320	0	cholesterol	90,101	cholesteryl_ester_transfer_protein	10,44	cholesterol	cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	concentration|compound|START_ENTITY associated|nmod|concentration associated|nsubjpass|polymorphism polymorphism|compound|END_ENTITY	The human cholesteryl_ester_transfer_protein I405V polymorphism is associated with plasma cholesterol concentration and its reduction by dietary phytosterol_esters .
1401066	0	cholesterol	8,19	cholesteryl_ester_transfer_protein	57,91	cholesterol	cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|transcription transcription|nmod|gene gene|compound|END_ENTITY	Dietary cholesterol increases transcription of the human cholesteryl_ester_transfer_protein gene in transgenic_mice .
14998629	0	cholesterol	72,83	cholesteryl_ester_transfer_protein	4,38	cholesterol	cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	polymorphism|nmod|START_ENTITY polymorphism|amod|END_ENTITY	The cholesteryl_ester_transfer_protein -LRB- CETP -RRB- TaqIB polymorphism in the cholesterol and recurrent events study : no interaction with the response to pravastatin therapy and no effects on cardiovascular outcome : a prospective analysis of the CETP TaqIB polymorphism on cardiovascular outcome and interaction with cholesterol-lowering therapy .
15071125	0	cholesterol	69,80	cholesteryl_ester_transfer_protein	27,61	cholesterol	cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|inhibitor inhibitor|nmod|END_ENTITY	Effects of an inhibitor of cholesteryl_ester_transfer_protein on HDL cholesterol .
15461565	0	cholesterol	33,44	cholesteryl_ester_transfer_protein	64,98	cholesterol	cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Raising high-density lipoprotein cholesterol with inhibitors of cholesteryl_ester_transfer_protein - a new approach to coronary_artery_disease .
15824213	0	cholesterol	36,47	cholesteryl_ester_transfer_protein	67,101	cholesterol	cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|compound|END_ENTITY	Increasing high-density lipoprotein cholesterol in dyslipidemia by cholesteryl_ester_transfer_protein inhibition : an update for clinicians .
15840744	0	cholesterol	108,119	cholesteryl_ester_transfer_protein	14,48	cholesterol	cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	>|nmod|START_ENTITY C|parataxis|> C|compound|END_ENTITY	The effect of cholesteryl_ester_transfer_protein -629 C - > A promoter polymorphism on high-density lipoprotein cholesterol is dependent on serum triglycerides .
16106052	0	cholesterol	61,72	cholesteryl_ester_transfer_protein	23,57	cholesterol	cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	Lack|nmod|START_ENTITY Lack|nmod|END_ENTITY	Lack of stimulation of cholesteryl_ester_transfer_protein by cholesterol in the presence of a high-fat diet .
1644921	0	cholesterol	198,209	cholesteryl_ester_transfer_protein	33,67	cholesterol	cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	levels|compound|START_ENTITY depression|nmod|levels interaction|nmod|depression interaction|nmod|END_ENTITY	An interaction between the human cholesteryl_ester_transfer_protein -LRB- CETP -RRB- and apolipoprotein_A-I genes in transgenic_mice results in a profound CETP-mediated depression of high density lipoprotein cholesterol levels .
16684835	0	cholesterol	165,176	cholesteryl_ester_transfer_protein	67,101	cholesterol	cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	relate|nmod|START_ENTITY variations|acl:relcl|relate variations|compound|END_ENTITY	An increased coronary risk is paradoxically associated with common cholesteryl_ester_transfer_protein gene variations that relate to higher high-density lipoprotein cholesterol : a population-based study .
16829344	0	cholesterol	101,112	cholesteryl_ester_transfer_protein	17,51	cholesterol	cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	response|compound|START_ENTITY influence|dobj|response influence|nsubj|Variation Variation|nmod|gene gene|amod|END_ENTITY	Variation in the cholesteryl_ester_transfer_protein -LRB- CETP -RRB- gene does not influence individual plasma cholesterol response to changes in the nature of dietary fat .
17084249	0	cholesterol	149,160	cholesteryl_ester_transfer_protein	44,78	cholesterol	cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	levels|compound|START_ENTITY individuals|nmod|levels Efficacy|nmod|individuals Efficacy|nmod|torcetrapib torcetrapib|appos|inhibitor inhibitor|compound|END_ENTITY	Efficacy and safety of torcetrapib , a novel cholesteryl_ester_transfer_protein inhibitor , in individuals with below-average high-density lipoprotein cholesterol levels .
17322101	0	cholesterol	94,105	cholesteryl_ester_transfer_protein	14,48	cholesterol	cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	efflux|compound|START_ENTITY increases|dobj|efflux increases|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of cholesteryl_ester_transfer_protein by torcetrapib modestly increases macrophage cholesterol efflux to HDL .
17440012	0	cholesterol	108,119	cholesteryl_ester_transfer_protein	20,54	cholesterol	cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	levels|compound|START_ENTITY effect|nmod|levels effect|nmod|END_ENTITY	Epistatic effect of cholesteryl_ester_transfer_protein and hepatic_lipase on serum high-density lipoprotein cholesterol levels .
17709925	0	cholesterol	98,109	cholesteryl_ester_transfer_protein	6,40	cholesterol	cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	levels|nmod|START_ENTITY associated|nmod|levels associated|nsubjpass|concentrations concentrations|compound|END_ENTITY	Serum cholesteryl_ester_transfer_protein concentrations are associated with serum levels of total cholesterol , beta-lipoprotein and apoproteins in patients with type_2_diabetes_mellitus .
18164013	0	cholesterol	9,20	cholesteryl_ester_transfer_protein	100,134	cholesterol	cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	protect|nsubj|START_ENTITY protect|advcl|associated associated|nmod|END_ENTITY	High HDL cholesterol does not protect against coronary_artery_disease when associated with combined cholesteryl_ester_transfer_protein and hepatic_lipase gene variants .
18178167	0	cholesterol	46,57	cholesteryl_ester_transfer_protein	98,132	cholesterol	cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	efflux|compound|START_ENTITY stimulate|dobj|efflux plasma|acl|stimulate ability|nmod|plasma associated|nsubjpass|ability associated|parataxis|_ _|nsubj|polymorphism polymorphism|amod|END_ENTITY	The ability of plasma to stimulate fibroblast cholesterol efflux is associated with the -629 C -- > A cholesteryl_ester_transfer_protein promoter polymorphism : role of lecithin : _ cholesterol_acyltransferase activity .
19056069	0	cholesterol	110,121	cholesteryl_ester_transfer_protein	19,53	cholesterol	cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	concentrations|compound|START_ENTITY genotype|nmod|concentrations genotype|amod|END_ENTITY	Association of the cholesteryl_ester_transfer_protein Taq1 B2B2 genotype with higher high-density lipoprotein cholesterol concentrations and lower risk of coronary_artery_disease in a Tunisian population .
19784962	0	cholesterol	103,114	cholesteryl_ester_transfer_protein	15,49	cholesterol	cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	levels|compound|START_ENTITY _|nmod|levels _|nsubj|Association Association|nmod|> >|compound|END_ENTITY	Association of cholesteryl_ester_transfer_protein -629 C _ > _ A polymorphism with high-density lipoprotein cholesterol levels in coronary_artery_disease patients .
1980239	0	cholesterol	119,130	cholesteryl_ester_transfer_protein	37,71	cholesterol	cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	plasma|dobj|START_ENTITY related|xcomp|plasma related|nsubjpass|Polymorphisms Polymorphisms|nmod|coding coding|nmod|END_ENTITY	Polymorphisms in the gene coding for cholesteryl_ester_transfer_protein are related to plasma high-density lipoprotein cholesterol and transfer protein activity .
19926784	0	cholesterol	4,15	cholesteryl_ester_transfer_protein	69,103	cholesterol	cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	response|compound|START_ENTITY associated|nsubjpass|response associated|nmod|variation variation|compound|END_ENTITY	HDL cholesterol response to GH replacement is associated with common cholesteryl_ester_transfer_protein gene variation -LRB- -629 C > A -RRB- and modified by glucocorticoid treatment .
20005542	0	cholesterol	144,155	cholesteryl_ester_transfer_protein	8,42	cholesterol	cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	concentration|compound|START_ENTITY decrease|nmod|concentration associated|nmod|decrease associated|nsubjpass|concentration concentration|compound|END_ENTITY	Fasting cholesteryl_ester_transfer_protein concentration is independently associated with the postprandial decrease in high-density lipoprotein cholesterol concentration after fat-rich meals : the Hoorn prandial study .
20398902	0	cholesterol	93,104	cholesteryl_ester_transfer_protein	7,41	cholesterol	cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	related|nmod|START_ENTITY variation|acl|related variation|compound|END_ENTITY	Common cholesteryl_ester_transfer_protein gene variation related to high-density lipoprotein cholesterol is not associated with decreased coronary_heart_disease risk after a 10-year follow-up in a Mediterranean cohort : Modulation by alcohol consumption .
2040599	0	cholesterol	33,44	cholesteryl_ester_transfer_protein	54,88	cholesterol	cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	START_ENTITY|nmod|transgenic_mice transgenic_mice|compound|END_ENTITY	Reduced high density lipoprotein cholesterol in human cholesteryl_ester_transfer_protein transgenic_mice .
2044257	0	cholesterol	54,65	cholesteryl_ester_transfer_protein	8,42	cholesterol	cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	transport|compound|START_ENTITY Role|nmod|transport Role|nmod|END_ENTITY	Role of cholesteryl_ester_transfer_protein in reverse cholesterol transport .
2127749	0	cholesterol	35,46	cholesteryl_ester_transfer_protein	93,127	cholesterol	cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	concentration|compound|START_ENTITY related|nsubjpass|concentration related|nmod|activity activity|compound|END_ENTITY	Increased high-density lipoprotein cholesterol concentration in alcoholics is related to low cholesteryl_ester_transfer_protein activity .
21957197	0	cholesterol	112,123	cholesteryl_ester_transfer_protein	59,93	cholesterol	cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	elevates|dobj|START_ENTITY inhibitor|acl:relcl|elevates inhibitor|nmod|END_ENTITY	Evacetrapib is a novel , potent , and selective inhibitor of cholesteryl_ester_transfer_protein that elevates HDL cholesterol without inducing aldosterone or increasing blood pressure .
22871191	0	cholesterol	132,143	cholesteryl_ester_transfer_protein	68,102	cholesterol	cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	levels|compound|START_ENTITY HDL|dobj|levels modulator|ccomp|HDL modulator|nsubj|update update|nmod|development development|nmod|dalcetrapib dalcetrapib|appos|END_ENTITY	An update on the clinical development of dalcetrapib -LRB- RO4607381 -RRB- , a cholesteryl_ester_transfer_protein modulator that increases HDL cholesterol levels .
23139291	0	cholesterol	21,32	cholesteryl_ester_transfer_protein	48,82	cholesterol	cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	transport|compound|START_ENTITY Upregulating|dobj|transport Upregulating|nmod|inhibition inhibition|compound|END_ENTITY	Upregulating reverse cholesterol transport with cholesteryl_ester_transfer_protein inhibition requires combination with the LDL-lowering drug berberine in dyslipidemic hamsters .
24467215	0	cholesterol	10,21	cholesteryl_ester_transfer_protein	59,93	cholesterol	cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	capacity|compound|START_ENTITY capacity|nmod|levels levels|compound|END_ENTITY	Decreased cholesterol efflux capacity in patients with low cholesteryl_ester_transfer_protein plasma levels .
25366166	0	cholesterol	101,112	cholesteryl_ester_transfer_protein	15,49	cholesterol	cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	START_ENTITY|dep|Association Association|nmod|gene gene|compound|END_ENTITY	Association of cholesteryl_ester_transfer_protein -LRB- CETP -RRB- gene polymorphism , high density lipoprotein cholesterol and risk of coronary_artery_disease : a meta-analysis using a Mendelian randomization approach .
2564326	0	cholesterol	126,137	cholesteryl_ester_transfer_protein	40,74	cholesterol	cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|polymorphism polymorphism|nmod|locus locus|nmod|END_ENTITY	DNA polymorphism at the locus for human cholesteryl_ester_transfer_protein -LRB- CETP -RRB- is associated with high density lipoprotein cholesterol and apolipoprotein levels .
7749855	0	cholesterol	111,122	cholesteryl_ester_transfer_protein	24,58	cholesterol	cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	concentrations|compound|START_ENTITY distribution|nmod|concentrations distribution|nmod|activities activities|compound|END_ENTITY	Bimodal distribution of cholesteryl_ester_transfer_protein activities in normotriglyceridemic men with low HDL cholesterol concentrations .
7822240	0	cholesterol	148,159	cholesteryl_ester_transfer_protein	62,96	cholesterol	cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	accumulation|compound|START_ENTITY protect|nmod|accumulation _|ccomp|protect _|nsubj|lipoproteins lipoproteins|nmod|_ _|compound|END_ENTITY	Large and cholesteryl_ester-rich high-density lipoproteins in cholesteryl_ester_transfer_protein _ -LRB- CETP -RRB- _ deficiency can not protect macrophages from cholesterol accumulation induced by acetylated low-density lipoproteins .
7962532	0	cholesterol	159,170	cholesteryl_ester_transfer_protein	8,42	cholesterol	cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	levels|nmod|START_ENTITY determinant|nmod|levels caused|nmod|determinant caused|nsubj|deficiency deficiency|compound|END_ENTITY	Genetic cholesteryl_ester_transfer_protein deficiency caused by two prevalent mutations as a major determinant of increased levels of high density lipoprotein cholesterol .
7998976	0	cholesterol	23,34	cholesteryl_ester_transfer_protein	54,88	cholesterol	cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|nmod|END_ENTITY	Effect of unesterified cholesterol on the activity of cholesteryl_ester_transfer_protein .
8509722	0	cholesterol	90,101	cholesteryl_ester_transfer_protein	15,49	cholesterol	cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	mRNA|dep|START_ENTITY mRNA|compound|END_ENTITY	Adipose tissue cholesteryl_ester_transfer_protein mRNA in response to probucol treatment : cholesterol and species dependence .
8529997	0	cholesterol	119,130	cholesteryl_ester_transfer_protein	166,200	cholesterol	cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	determinant|nmod|START_ENTITY promoter|nmod|determinant substitution|nmod|promoter Evaluation|nmod|substitution level|nsubj|Evaluation level|nmod|deficiency deficiency|compound|END_ENTITY	Evaluation of G-to-A substitution in the apolipoprotein_A-I gene promoter as a determinant of high-density lipoprotein cholesterol level in subjects with and without cholesteryl_ester_transfer_protein deficiency .
8702580	0	cholesterol	30,41	cholesteryl_ester_transfer_protein	92,126	cholesterol	cholesteryl ester transfer protein	MESH:D002784	100327267(Tax:9986)	Chemical	Gene	levels|compound|START_ENTITY lipoprotein|dobj|levels lipoprotein|nmod|oligodeoxynucleotides oligodeoxynucleotides|nmod|END_ENTITY	Changes in plasma lipoprotein cholesterol levels by antisense oligodeoxynucleotides against cholesteryl_ester_transfer_protein in cholesterol-fed rabbits .
8725167	0	cholesterol	95,106	cholesteryl_ester_transfer_protein	45,79	cholesterol	cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	secretes|nmod|START_ENTITY secretes|dobj|END_ENTITY	Human_liposarcoma cell line , SW872 , secretes cholesteryl_ester_transfer_protein in response to cholesterol .
9054466	0	cholesterol	68,79	cholesteryl_ester_transfer_protein	166,200	cholesterol	cholesteryl ester transfer protein	MESH:D002784	100327267(Tax:9986)	Chemical	Gene	levels|compound|START_ENTITY elevates|dobj|levels elevates|advcl|increasing increasing|nmod|effect effect|nmod|activity activity|compound|END_ENTITY	The novel compound NO-1886 elevates plasma high-density lipoprotein cholesterol levels in hamsters and rabbits by increasing lipoprotein lipase without any effect on cholesteryl_ester_transfer_protein activity .
9670349	0	cholesterol	25,36	cholesteryl_ester_transfer_protein	61,95	cholesterol	cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	related|nsubjpass|START_ENTITY related|nmod|polymorphism polymorphism|compound|END_ENTITY	High-density lipoprotein cholesterol is related to the TaqIB cholesteryl_ester_transfer_protein gene polymorphism and smoking , but not to moderate alcohol consumption in insulin-dependent diabetic men .
9808796	0	cholesterol	98,109	cholesteryl_ester_transfer_protein	146,180	cholesterol	cholesteryl ester transfer protein	MESH:D002784	1071	Chemical	Gene	subjects|nmod|START_ENTITY coronary_heart_disease|nmod|subjects levels|amod|coronary_heart_disease levels|nmod|those those|nmod|deficiency deficiency|compound|END_ENTITY	A low prevalence of coronary_heart_disease among subjects with increased high-density lipoprotein cholesterol levels , including those with plasma cholesteryl_ester_transfer_protein deficiency .
8431464	1	cholesterol	106,117	cytochrome_P-450SCC	136,155	cholesterol	cytochrome P-450SCC	MESH:D002784	338048(Tax:9913)	Chemical	Gene	region|compound|START_ENTITY region|nmod|END_ENTITY	Identification and primary structure of the cholesterol binding region in cytochrome_P-450SCC .
12617470	0	cholesterol	49,60	cytochrome_P450	12,27	cholesterol	cytochrome P450	MESH:D002784	4051	Chemical	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	The role of cytochrome_P450 in the regulation of cholesterol biosynthesis .
14690017	0	cholesterol	56,67	cytochrome_P450	86,101	cholesterol	cytochrome P450	MESH:D002784	25251(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY enhances|dobj|transport enhances|nmod|activation activation|amod|END_ENTITY	Clofibrate , a peroxisome-proliferator , enhances reverse cholesterol transport through cytochrome_P450 activation and oxysterol generation .
1611996	0	cholesterol	63,74	cytochrome_P450	95,110	cholesterol	cytochrome P450	MESH:D002784	100328948(Tax:9986)	Chemical	Gene	side-chain|compound|START_ENTITY side-chain|dep|expression expression|amod|END_ENTITY	Inherited congenital_adrenal_hyperplasia in the rabbit : absent cholesterol side-chain cleavage cytochrome_P450 gene expression .
1874173	0	cholesterol	23,34	cytochrome_P450	55,70	cholesterol	cytochrome P450	MESH:D002784	4051	Chemical	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Interleukin-1 inhibits cholesterol side-chain cleavage cytochrome_P450 expression in primary cultures of Leydig cells .
8276137	0	cholesterol	42,53	cytochrome_P450	74,89	cholesterol	cytochrome P450	MESH:D002784	25251(Tax:10116)	Chemical	Gene	side-chain|compound|START_ENTITY insulin-like_growth_factor-I|nmod|side-chain Effect|nmod|insulin-like_growth_factor-I cleavage|nsubj|Effect cleavage|dobj|expression expression|amod|END_ENTITY	Effect of insulin-like_growth_factor-I on cholesterol side-chain cleavage cytochrome_P450 messenger ribonucleic acid expression in ovarian theca-interstitial cells stimulated to differentiate in vitro .
8975714	0	cholesterol	120,131	cytochrome_P450	92,107	cholesterol	cytochrome P450	MESH:D002784	4051	Chemical	Gene	biosynthesis|compound|START_ENTITY involved|nmod|biosynthesis END_ENTITY|acl|involved	Structure and mapping of the human lanosterol_14alpha-demethylase gene -LRB- CYP51 -RRB- encoding the cytochrome_P450 involved in cholesterol biosynthesis ; comparison of exon/intron organization with other mammalian and fungal CYP genes .
8984122	0	cholesterol	64,75	cytochrome_p450	34,49	cholesterol	cytochrome p450	MESH:D002784	25251(Tax:10116)	Chemical	Gene	beta-hydroxylase|nmod|START_ENTITY beta-hydroxylase|dobj|expression expression|amod|END_ENTITY	Regulation of 11 beta-hydroxylase cytochrome_p450 expression by cholesterol in spontaneously hypertensive rats .
7458986	0	cholesterol	74,85	elastin	17,24	cholesterol	elastin	MESH:D002784	100344271(Tax:9986)	Chemical	Gene	synthesis|nmod|START_ENTITY synthesis|compound|END_ENTITY	Aortic collagen , elastin and non-fibrous protein synthesis in rabbits red cholesterol and peanut oil .
3046617	0	cholesterol	16,27	erg6	48,52	cholesterol	erg6	MESH:D002784	855003(Tax:4932)	Chemical	Gene	Biosynthesis|nmod|START_ENTITY Biosynthesis|nmod|END_ENTITY	Biosynthesis of cholesterol in the yeast mutant erg6 .
15694942	0	cholesterol	94,105	estrogen_receptor_alpha	27,50	cholesterol	estrogen receptor alpha	MESH:D002784	2099	Chemical	Gene	response|compound|START_ENTITY haplotype|nmod|response haplotype|compound|END_ENTITY	Gender-specific effects of estrogen_receptor_alpha gene haplotype on high-density lipoprotein cholesterol response to atorvastatin : interaction with apolipoprotein AI gene polymorphism .
19196801	0	cholesterol	74,85	estrogen_receptor_alpha	102,125	cholesterol	estrogen receptor alpha	MESH:D002784	13982(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY homeostasis|nmod|END_ENTITY	Increased exposure to estrogens disturbs maturation , steroidogenesis , and cholesterol homeostasis via estrogen_receptor_alpha in adult mouse Leydig cells .
24954418	0	cholesterol	4,15	estrogen_receptor_alpha	116,139	cholesterol	estrogen receptor alpha	MESH:D002784	13982(Tax:10090)	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|atherosclerosis atherosclerosis|nmod|processes processes|acl|mediated mediated|nmod|END_ENTITY	The cholesterol metabolite 27-hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen_receptor_alpha .
20132805	0	cholesterol	10,21	factor_VIII	59,70	cholesterol	factor VIII	MESH:D002784	2157	Chemical	Gene	content|compound|START_ENTITY Effect|nmod|content Effect|nmod|END_ENTITY	Effect of cholesterol content on affinity and stability of factor_VIII and annexin_V binding to a liposomal bilayer membrane .
10235090	0	cholesterol	24,35	familial_hypercholesterolemia	90,119	cholesterol	familial hypercholesterolemia	MESH:D002784	3949	Chemical	Gene	bulk|compound|START_ENTITY determinant|nsubj|bulk determinant|nmod|atherosclerosis atherosclerosis|nmod|END_ENTITY	Low-density lipoprotein cholesterol bulk is the pivotal determinant of atherosclerosis in familial_hypercholesterolemia .
10669649	0	cholesterol	63,74	familial_hypercholesterolemia	92,121	cholesterol	familial hypercholesterolemia	MESH:D002784	3949	Chemical	Gene	lowers|dobj|START_ENTITY lowers|nmod|families families|nmod|END_ENTITY	Stanol_ester margarine alone and with simvastatin lowers serum cholesterol in families with familial_hypercholesterolemia caused by the FH-North Karelia mutation .
11718692	0	cholesterol	31,42	familial_hypercholesterolemia	60,89	cholesterol	familial hypercholesterolemia	MESH:D002784	3949	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	Quantity versus quality of LDL cholesterol in patients with familial_hypercholesterolemia -- which is more important ?
12910492	0	cholesterol	60,71	familial_hypercholesterolemia	85,114	cholesterol	familial hypercholesterolemia	MESH:D002784	3949	Chemical	Gene	phenotype|compound|START_ENTITY phenotype|nmod|END_ENTITY	Growth_hormone_receptor variant -LRB- L526I -RRB- modifies plasma HDL cholesterol phenotype in familial_hypercholesterolemia : intra-familial association study in an eight-generation hyperlipidemic kindred .
15149875	0	cholesterol	102,113	familial_hypercholesterolemia	51,80	cholesterol	familial hypercholesterolemia	MESH:D002784	3949	Chemical	Gene	absorption|compound|START_ENTITY inhibition|nmod|absorption Intralipid|nmod|inhibition Intralipid|nmod|patients patients|nmod|END_ENTITY	Removal of intravenous Intralipid in patients with familial_hypercholesterolemia during inhibition of cholesterol absorption and synthesis .
1632848	0	cholesterol	39,50	familial_hypercholesterolemia	80,109	cholesterol	familial hypercholesterolemia	MESH:D002784	3949	Chemical	Gene	START_ENTITY|nmod|treatment treatment|nmod|END_ENTITY	Non-macrophage-related accumulation of cholesterol during probucol treatment in familial_hypercholesterolemia : report of two cases .
16556855	0	cholesterol	17,28	familial_hypercholesterolemia	71,100	cholesterol	familial hypercholesterolemia	MESH:D002784	3949	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of HDL cholesterol on preclinical carotid_atherosclerosis in familial_hypercholesterolemia .
16647412	0	cholesterol	155,166	familial_hypercholesterolemia	80,109	cholesterol	familial hypercholesterolemia	MESH:D002784	3949	Chemical	Gene	levels|compound|START_ENTITY reduction|nmod|levels restore|nmod|reduction restore|nmod|END_ENTITY	Plant stanols do not restore endothelial function in pre-pubertal children with familial_hypercholesterolemia despite reduction of low-density lipoprotein cholesterol levels .
172531	0	cholesterol	13,24	familial_hypercholesterolemia	123,152	cholesterol	familial hypercholesterolemia	MESH:D002784	3949	Chemical	Gene	lipoprotein|compound|START_ENTITY Reduction|nmod|lipoprotein synthesis|nsubj|Reduction synthesis|nmod|END_ENTITY	Reduction in cholesterol and low density lipoprotein synthesis after portacaval shunt surgery in a patient with homozygous familial_hypercholesterolemia .
18503863	0	cholesterol	21,32	familial_hypercholesterolemia	46,75	cholesterol	familial hypercholesterolemia	MESH:D002784	3949	Chemical	Gene	granuloma|compound|START_ENTITY granuloma|nmod|END_ENTITY	Bilateral middle ear cholesterol granuloma in familial_hypercholesterolemia .
18603821	0	cholesterol	57,68	familial_hypercholesterolemia	123,152	cholesterol	familial hypercholesterolemia	MESH:D002784	3949	Chemical	Gene	cholesterol|compound|START_ENTITY cholesterol|nmod|END_ENTITY	Effects of statin on small dense low-density lipoprotein cholesterol and remnant-like particle cholesterol in heterozygous familial_hypercholesterolemia .
19917273	0	cholesterol	96,107	familial_hypercholesterolemia	111,140	cholesterol	familial hypercholesterolemia	MESH:D002784	3949	Chemical	Gene	START_ENTITY|nmod|heterozygotes heterozygotes|compound|END_ENTITY	Loss-of-function mutation R46L in the PCSK9 gene has little impact on the levels of total serum cholesterol in familial_hypercholesterolemia heterozygotes .
215170	0	cholesterol	49,60	familial_hypercholesterolemia	80,109	cholesterol	familial hypercholesterolemia	MESH:D002784	3949	Chemical	Gene	concentration|compound|START_ENTITY plasmapheresis|nmod|concentration plasmapheresis|nmod|END_ENTITY	Effect of intessive plasmapheresis on the plasma cholesterol concentration with familial_hypercholesterolemia .
21527752	0	cholesterol	25,36	familial_hypercholesterolemia	71,100	cholesterol	familial hypercholesterolemia	MESH:D002784	3949	Chemical	Gene	transport|compound|START_ENTITY defective|nsubj|transport defective|nmod|END_ENTITY	Atheroprotective reverse cholesterol transport pathway is defective in familial_hypercholesterolemia .
22338009	0	cholesterol	52,63	familial_hypercholesterolemia	85,114	cholesterol	familial hypercholesterolemia	MESH:D002784	3949	Chemical	Gene	pathway|compound|START_ENTITY pathway|nmod|END_ENTITY	Impact of LDL apheresis on atheroprotective reverse cholesterol transport pathway in familial_hypercholesterolemia .
22510809	0	cholesterol	8,19	familial_hypercholesterolemia	33,62	cholesterol	familial hypercholesterolemia	MESH:D002784	3949	Chemical	Gene	transport|compound|START_ENTITY transport|nmod|END_ENTITY	Reverse cholesterol transport in familial_hypercholesterolemia .
22583789	0	cholesterol	114,125	familial_hypercholesterolemia	175,204	cholesterol	familial hypercholesterolemia	MESH:D002784	3949	Chemical	Gene	improvements|nmod|START_ENTITY associated|nmod|improvements associated|nmod|people people|nmod|END_ENTITY	Is the process of delivery of an individually tailored lifestyle intervention associated with improvements in LDL cholesterol and multiple lifestyle behaviours in people with familial_hypercholesterolemia ?
24530965	0	cholesterol	119,130	familial_hypercholesterolemia	14,43	cholesterol	familial hypercholesterolemia	MESH:D002784	3949	Chemical	Gene	characterized|nmod|START_ENTITY characterized|nsubjpass|Subjects Subjects|nmod|END_ENTITY	Subjects with familial_hypercholesterolemia are characterized by an inflammatory phenotype despite long-term intensive cholesterol lowering treatment .
2552800	0	cholesterol	142,153	familial_hypercholesterolemia	84,113	cholesterol	familial hypercholesterolemia	MESH:D002784	3949	Chemical	Gene	treatment|nmod|START_ENTITY lowering|nsubj|treatment function|advcl|lowering function|nmod|lymphocytes lymphocytes|nmod|patients patients|nmod|END_ENTITY	Normalization of LDL_receptor function by lymphocytes of patients with heterozygous familial_hypercholesterolemia after treatment with plasma cholesterol lowering agents .
2567693	0	cholesterol	77,88	familial_hypercholesterolemia	98,127	cholesterol	familial hypercholesterolemia	MESH:D002784	3949	Chemical	Gene	level|compound|START_ENTITY level|nmod|END_ENTITY	Genetic polymorphism of the apolipoprotein_B gene locus influences serum LDL cholesterol level in familial_hypercholesterolemia .
26386212	0	cholesterol	38,49	familial_hypercholesterolemia	74,103	cholesterol	familial hypercholesterolemia	MESH:D002784	3949	Chemical	Gene	levels|compound|START_ENTITY predict|dobj|levels predict|nmod|children children|nmod|END_ENTITY	Maternal inheritance does not predict cholesterol levels in children with familial_hypercholesterolemia .
2725293	0	cholesterol	44,55	familial_hypercholesterolemia	127,156	cholesterol	familial hypercholesterolemia	MESH:D002784	3949	Chemical	Gene	Reduction|nmod|START_ENTITY mevalonic_acid|nsubj|Reduction mevalonic_acid|nmod|patients patients|nmod|END_ENTITY	Reduction in plasma low-density lipoprotein cholesterol and urinary mevalonic_acid by lovastatin in patients with heterozygous familial_hypercholesterolemia .
3081013	0	cholesterol	44,55	familial_hypercholesterolemia	101,130	cholesterol	familial hypercholesterolemia	MESH:D002784	3949	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of probucol treatment on lipoprotein cholesterol and drug levels in blood and lipoproteins in familial_hypercholesterolemia .
3959903	0	cholesterol	66,77	familial_hypercholesterolemia	141,170	cholesterol	familial hypercholesterolemia	MESH:D002784	3949	Chemical	Gene	related|nmod|START_ENTITY related|nmod|myocardial_infarction myocardial_infarction|nmod|END_ENTITY	Plasma triglycerides related decrease in high-density lipoprotein cholesterol and its association with myocardial_infarction in heterozygous familial_hypercholesterolemia .
6572682	0	cholesterol	88,99	familial_hypercholesterolemia	118,147	cholesterol	familial hypercholesterolemia	MESH:D002784	3949	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|dep|comparisons comparisons|nmod|END_ENTITY	Low density lipoprotein metabolism in the normal to moderately elevated range of plasma cholesterol : comparisons with familial_hypercholesterolemia .
6572906	0	cholesterol	80,91	familial_hypercholesterolemia	13,42	cholesterol	familial hypercholesterolemia	MESH:D002784	3949	Chemical	Gene	metabolism|compound|START_ENTITY effect|nmod|metabolism Treatment|dep|effect Treatment|nmod|END_ENTITY	Treatment of familial_hypercholesterolemia by portacaval_anastomosis : effect on cholesterol metabolism and pool sizes .
7247990	0	cholesterol	6,17	familial_hypercholesterolemia	42,71	cholesterol	familial hypercholesterolemia	MESH:D002784	3949	Chemical	Gene	levels|compound|START_ENTITY levels|nmod|patients patients|nmod|END_ENTITY	Serum cholesterol levels in patients with familial_hypercholesterolemia confirmed by tissue culture .
7583547	1	cholesterol	66,77	familial_hypercholesterolemia	117,146	cholesterol	familial hypercholesterolemia	MESH:D002784	3949	Chemical	Gene	levels|compound|START_ENTITY cause|nmod|levels heterozygous|nsubj|cause heterozygous|nmod|END_ENTITY	A cause for low HDL cholesterol levels in individuals heterozygous for familial_hypercholesterolemia .
8801868	0	cholesterol	29,40	familial_hypercholesterolemia	53,82	cholesterol	familial hypercholesterolemia	MESH:D002784	3949	Chemical	Gene	thickness|nmod|START_ENTITY thickness|acl|lowering lowering|nmod|END_ENTITY	Intima-media thickness after cholesterol lowering in familial_hypercholesterolemia .
8931648	0	cholesterol	56,67	familial_hypercholesterolemia	98,127	cholesterol	familial hypercholesterolemia	MESH:D002784	3949	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|levels levels|nmod|END_ENTITY	The effect of growth_hormone on low-density lipoprotein cholesterol and lipoprotein -LRB- a -RRB- levels in familial_hypercholesterolemia .
9315520	0	cholesterol	7,18	familial_hypercholesterolemia	74,103	cholesterol	familial hypercholesterolemia	MESH:D002784	3949	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Plasma cholesterol regulates soluble cell adhesion molecule expression in familial_hypercholesterolemia .
9671018	0	cholesterol	64,75	familial_hypercholesterolemia	131,160	cholesterol	familial hypercholesterolemia	MESH:D002784	3949	Chemical	Gene	response|nmod|START_ENTITY response|acl|lowering lowering|nmod|pravastatin pravastatin|nmod|END_ENTITY	Low-density_lipoprotein_receptor genotype-dependent response to cholesterol lowering by combined pravastatin and cholestyramine in familial_hypercholesterolemia .
9701246	0	cholesterol	96,107	familial_hypercholesterolemia	23,52	cholesterol	familial hypercholesterolemia	MESH:D002784	3949	Chemical	Gene	levels|compound|START_ENTITY model|dep|levels model|nmod|END_ENTITY	A mouse model of human familial_hypercholesterolemia : markedly elevated low density lipoprotein cholesterol levels and severe atherosclerosis on a low-fat chow diet .
12421815	0	cholesterol	54,65	farnesoid_X-receptor	4,24	cholesterol	farnesoid X-receptor	MESH:D002784	20186(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY regulator|nmod|homeostasis regulator|nsubj|END_ENTITY	The farnesoid_X-receptor is an essential regulator of cholesterol homeostasis .
26218418	0	cholesterol	44,55	flavin_monooxygenase_3	18,40	cholesterol	flavin monooxygenase 3	MESH:D002784	14262(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	Emerging roles of flavin_monooxygenase_3 in cholesterol metabolism and atherosclerosis .
11012570	0	cholesterol	35,46	growth_hormone	103,117	cholesterol	growth hormone	MESH:D002784	2688	Chemical	Gene	circulating|dobj|START_ENTITY reduction|acl|circulating reduction|acl|given given|dobj|therapy therapy|amod|END_ENTITY	Sustained reduction in circulating cholesterol in adult hypopituitary patients given low dose titrated growth_hormone replacement therapy : a two year study .
2013748	0	cholesterol	110,121	growth_hormone	50,64	cholesterol	growth hormone	MESH:D002784	81668(Tax:10116)	Chemical	Gene	concentrations|nmod|START_ENTITY regulation|nmod|concentrations Evidence|nmod|regulation Evidence|nmod|role role|nmod|pattern pattern|nmod|END_ENTITY	Evidence for the role of the secretory pattern of growth_hormone in the regulation of serum concentrations of cholesterol and apolipoprotein_E in rats .
23926408	0	cholesterol	48,59	growth_hormone	20,34	cholesterol	growth hormone	MESH:D002784	2688	Chemical	Gene	levels|compound|START_ENTITY impact|nmod|levels impact|nmod|treatment treatment|amod|END_ENTITY	Favorable impact of growth_hormone treatment on cholesterol levels in turner_syndrome .
514086	0	cholesterol	6,17	growth_hormone	53,67	cholesterol	growth hormone	MESH:D002784	2688	Chemical	Gene	Serum|dobj|START_ENTITY Serum|nmod|children children|nmod|deficiency deficiency|amod|END_ENTITY	Serum cholesterol and triglycerides in children with growth_hormone deficiency .
6619265	0	cholesterol	54,65	growth_hormone	18,32	cholesterol	growth hormone	MESH:D002784	2688	Chemical	Gene	metabolism|compound|START_ENTITY regulation|nmod|metabolism role|nmod|regulation role|nmod|END_ENTITY	The role of human growth_hormone in the regulation of cholesterol and bile_acid metabolism .
8415619	0	cholesterol	30,41	growth_hormone	105,119	cholesterol	growth hormone	MESH:D002784	81668(Tax:10116)	Chemical	Gene	dietary|dobj|START_ENTITY Loss|acl|dietary Loss|dep|importance importance|nmod|presence presence|nmod|END_ENTITY	Loss of resistance to dietary cholesterol in the rat after hypophysectomy : importance of the presence of growth_hormone for hepatic low_density_lipoprotein-receptor expression .
9071966	0	cholesterol	29,40	growth_hormone	11,25	cholesterol	growth hormone	MESH:D002784	81668(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY Effects|nmod|metabolism Effects|nmod|END_ENTITY	Effects of growth_hormone on cholesterol metabolism in the lactating rat mammary gland .
9284893	0	cholesterol	84,95	growth_hormone	6,20	cholesterol	growth hormone	MESH:D002784	2688	Chemical	Gene	levels|compound|START_ENTITY correlated|nmod|levels correlated|nsubjpass|levels levels|compound|END_ENTITY	Basal growth_hormone levels are positively correlated with high-density lipoprotein cholesterol levels in women .
9500574	0	cholesterol	93,104	growth_hormone	6,20	cholesterol	growth hormone	MESH:D002784	2688	Chemical	Gene	correlated|nmod|START_ENTITY correlated|nsubjpass|levels levels|compound|END_ENTITY	Basal growth_hormone levels in women are positively correlated with high-density lipoprotein cholesterol and apolipoprotein_A-I independently of insulin-like_growth_factor_1 or insulin .
10073966	0	cholesterol	101,112	hepatic_lipase	24,38	cholesterol	hepatic lipase	MESH:D002784	3990	Chemical	Gene	attenuates|nmod|START_ENTITY attenuates|nsubj|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of human hepatic_lipase and ApoE in transgenic rabbits attenuates response to dietary cholesterol and alters lipoprotein subclass distributions .
10924721	0	cholesterol	73,84	hepatic_lipase	25,39	cholesterol	hepatic lipase	MESH:D002784	3990	Chemical	Gene	levels|compound|START_ENTITY associated|nmod|levels associated|nsubjpass|mutation mutation|nmod|gene gene|amod|END_ENTITY	The V73M mutation in the hepatic_lipase gene is associated with elevated cholesterol levels in four Dutch pedigrees with familial_combined_hyperlipidemia .
11322655	0	cholesterol	75,86	hepatic_lipase	11,25	cholesterol	hepatic lipase	MESH:D002784	3990	Chemical	Gene	concentration|compound|START_ENTITY HDL|dobj|concentration HDL|nsubj|Effects Effects|nmod|variations variations|amod|END_ENTITY	Effects of hepatic_lipase gene promoter nucleotide variations on serum HDL cholesterol concentration in the general Japanese population .
11947893	0	cholesterol	85,96	hepatic_lipase	44,58	cholesterol	hepatic lipase	MESH:D002784	3990	Chemical	Gene	levels|compound|START_ENTITY serum|dobj|levels Relation|acl|serum Relation|nmod|polymorphism polymorphism|nmod|gene gene|amod|END_ENTITY	Relation of the -514 C/T polymorphism in the hepatic_lipase gene to serum HDL and LDL cholesterol levels in postmenopausal women under hormone replacement therapy .
12519412	0	cholesterol	41,52	hepatic_lipase	67,81	cholesterol	hepatic lipase	MESH:D002784	3990	Chemical	Gene	lowers|dobj|START_ENTITY lowers|advcl|increasing increasing|dobj|activity activity|amod|END_ENTITY	Tibolone lowers high density lipoprotein cholesterol by increasing hepatic_lipase activity but does not impair cholesterol efflux .
1420288	0	cholesterol	52,63	hepatic_lipase	23,37	cholesterol	hepatic lipase	MESH:D002784	24538(Tax:10116)	Chemical	Gene	acyltransferase|compound|START_ENTITY regulation|dep|acyltransferase regulation|nmod|END_ENTITY	Opposite regulation of hepatic_lipase and lecithin : cholesterol acyltransferase by glucocorticoids in rats .
14679168	0	cholesterol	54,65	hepatic_lipase	25,39	cholesterol	hepatic lipase	MESH:D002784	15450(Tax:10090)	Chemical	Gene	clears|dobj|START_ENTITY clears|nsubj|function function|nmod|END_ENTITY	The bridging function of hepatic_lipase clears plasma cholesterol in LDL_receptor-deficient `` apoB-48-only '' and `` apoB-100-only '' mice .
14709367	0	cholesterol	119,130	hepatic_lipase	27,41	cholesterol	hepatic lipase	MESH:D002784	3990	Chemical	Gene	levels|compound|START_ENTITY polymorphisms|nmod|levels polymorphisms|nsubj|effects effects|nmod|promoter promoter|amod|END_ENTITY	The interactive effects of hepatic_lipase gene promoter polymorphisms with sex and obesity on high-density-lipoprotein cholesterol levels in Taiwanese-Chinese .
16330034	0	cholesterol	119,130	hepatic_lipase	17,31	cholesterol	hepatic lipase	MESH:D002784	3990	Chemical	Gene	level|compound|START_ENTITY independent|nmod|level independent|nsubj|influence influence|nmod|polymorphism polymorphism|amod|END_ENTITY	The influence of hepatic_lipase C-480T polymorphism on coronary flow reserve in young men is independent of the plasma cholesterol level .
1742328	0	cholesterol	88,99	hepatic_lipase	18,32	cholesterol	hepatic lipase	MESH:D002784	100008678(Tax:9986)	Chemical	Gene	rabbit|compound|START_ENTITY regulation|nmod|rabbit regulation|nmod|activity activity|compound|END_ENTITY	The regulation of hepatic_lipase and cholesteryl_ester_transfer_protein activity in the cholesterol fed rabbit .
18364377	0	cholesterol	111,122	hepatic_lipase	32,46	cholesterol	hepatic lipase	MESH:D002784	3990	Chemical	Gene	START_ENTITY|dep|variant variant|nmod|associates associates|amod|END_ENTITY	The -250 G > A promoter variant in hepatic_lipase associates with elevated fasting serum high-density lipoprotein cholesterol modulated by interaction with physical activity in a study of 16,156 Danish subjects .
21424685	0	cholesterol	91,102	hepatic_lipase	8,22	cholesterol	hepatic lipase	MESH:D002784	3990	Chemical	Gene	transport|compound|START_ENTITY Role|nmod|transport Role|nmod|END_ENTITY	Role of hepatic_lipase and endothelial_lipase in high-density lipoprotein-mediated reverse cholesterol transport .
3899172	0	cholesterol	81,92	hepatic_lipase	17,31	cholesterol	hepatic lipase	MESH:D002784	3990	Chemical	Gene	accumulation|nmod|START_ENTITY induced|dobj|accumulation induced|nsubj|Mechanism Mechanism|nmod|END_ENTITY	Mechanism of the hepatic_lipase induced accumulation of high-density lipoprotein cholesterol by cells in culture .
6790199	0	cholesterol	45,56	hepatic_lipase	92,106	cholesterol	hepatic lipase	MESH:D002784	3990	Chemical	Gene	Reduction|nmod|START_ENTITY END_ENTITY|nsubj|Reduction	Reduction of plasma high-density lipoprotein cholesterol and increase of postheparin plasma hepatic_lipase activity during progestin treatment .
7830494	0	cholesterol	18,29	hepatic_lipase	61,75	cholesterol	hepatic lipase	MESH:D002784	24538(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of dietary cholesterol on activity and mRNA levels of hepatic_lipase in rat .
7989594	0	cholesterol	135,146	hepatic_lipase	17,31	cholesterol	hepatic lipase	MESH:D002784	3990	Chemical	Gene	levels|compound|START_ENTITY variation|nmod|levels cause|nmod|variation cause|nsubj|Variation Variation|nmod|END_ENTITY	Variation at the hepatic_lipase and apolipoprotein AI/CIII/AIV loci is a major cause of genetically determined variation in plasma HDL cholesterol levels .
8117745	0	cholesterol	84,95	hepatic_lipase	22,36	cholesterol	hepatic lipase	MESH:D002784	24538(Tax:10116)	Chemical	Gene	influx|compound|START_ENTITY modify|dobj|influx diets|acl:relcl|modify activity|nmod|diets activity|amod|END_ENTITY	In vivo regulation of hepatic_lipase activity and mRNA levels by diets which modify cholesterol influx to the liver .
9114024	0	cholesterol	102,113	hepatic_lipase	2,16	cholesterol	hepatic lipase	MESH:D002784	3990	Chemical	Gene	concentrations|nmod|START_ENTITY associated|nmod|concentrations allele|dep|associated allele|nsubj|END_ENTITY	A hepatic_lipase -LRB- LIPC -RRB- allele associated with high plasma concentrations of high density lipoprotein cholesterol .
15761191	1	cholesterol	294,305	humans	246,252	cholesterol	apoA-I	MESH:D002784	335	Chemical	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	OBJECTIVE : Pharmacological inhibition of the cholesteryl_ester_transfer_protein -LRB- CETP -RRB- in humans increases high-density lipoprotein -LRB- HDL -RRB- cholesterol -LRB- HDL-C -RRB- levels ; however , its effects on apolipoprotein_A-I -LRB- apoA-I -RRB- containing HDL subspecies , apoA-I turnover , and markers of reverse cholesterol transport are unknown .
26800364	1	cholesterol	190,201	humans	216,222	cholesterol	NPC1L1	MESH:D002784	29881	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|nmod|END_ENTITY	UNASSIGNED : Niemann_Pick_Type_C1_Like_1 -LRB- NPC1L1 -RRB- protein plays a key role in intestinal and hepatic cholesterol metabolism in humans .
10656169	0	cholesterol	24,35	insulin	113,120	cholesterol	insulin	MESH:D002784	3630	Chemical	Gene	lipoprotein|dobj|START_ENTITY lipoprotein|dobj|isoforms isoforms|dep|relationship relationship|acl|fasting fasting|dobj|END_ENTITY	Low density lipoprotein cholesterol , lipoprotein -LRB- a -RRB- , and apo -LRB- a -RRB- isoforms in the elderly : relationship to fasting insulin .
10949103	0	cholesterol	13,24	insulin	37,44	cholesterol	insulin	MESH:D002784	3630	Chemical	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Influence of cholesterol and fasting insulin levels on blood pressure reactivity .
11300605	0	cholesterol	102,113	insulin	134,141	cholesterol	insulin	MESH:D002784	3630	Chemical	Gene	related|nmod|START_ENTITY related|nmod|resistance resistance|compound|END_ENTITY	Plasma cholesteryl_ester transfer and hepatic_lipase activity are related to high-density lipoprotein cholesterol in association with insulin resistance in type 2 diabetic and non-diabetic subjects .
12852722	0	cholesterol	143,154	insulin	199,206	cholesterol	insulin	MESH:D002784	3630	Chemical	Gene	START_ENTITY|appos|fibrinogen fibrinogen|appos|END_ENTITY	Improvement of glycaemic control in type 2 diabetes : favourable changes in blood pressure , total cholesterol and triglycerides , but not in HDL cholesterol , fibrinogen , Von_Willebrand_factor_and _ -LRB- pro -RRB- insulin .
1525117	0	cholesterol	67,78	insulin	13,20	cholesterol	insulin	MESH:D002784	3630	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|resistance resistance|compound|END_ENTITY	Influence of insulin resistance , secretion , and clearance on serum cholesterol , triglycerides , lipoprotein cholesterol , and blood pressure in healthy men .
17391174	0	cholesterol	35,46	insulin	110,117	cholesterol	insulin	MESH:D002784	3630	Chemical	Gene	START_ENTITY|dep|role role|nmod|resistance resistance|compound|END_ENTITY	Low serum high-density lipoprotein cholesterol in obese subjects with normal serum triglycerides : the role of insulin resistance and inflammatory cytokines .
17575085	0	cholesterol	17,28	insulin	32,39	cholesterol	insulin	MESH:D002784	3630	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Direct effect of cholesterol on insulin secretion : a novel mechanism for pancreatic_beta-cell_dysfunction .
1781671	0	cholesterol	65,76	insulin	142,149	cholesterol	insulin	MESH:D002784	3630	Chemical	Gene	concentrations|compound|START_ENTITY reduction|nmod|concentrations Influence|nmod|reduction Influence|dep|interrelationships interrelationships|nmod|levels levels|compound|END_ENTITY	Influence of weight reduction on plasma high-density-lipoprotein cholesterol concentrations in severe obesity : interrelationships with plasma insulin levels .
1931867	0	cholesterol	77,88	insulin	27,34	cholesterol	insulin	MESH:D002784	3630	Chemical	Gene	fasting|nmod|START_ENTITY fasting|dobj|concentration concentration|compound|END_ENTITY	Relation of fasting plasma insulin concentration to high density lipoprotein cholesterol and triglyceride concentrations in men .
19509184	0	cholesterol	29,40	insulin	63,70	cholesterol	insulin	MESH:D002784	3630	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|resistance resistance|compound|END_ENTITY	Metabolic effects of dietary cholesterol in an animal model of insulin resistance and hepatic_steatosis .
20413122	0	cholesterol	81,92	insulin	109,116	cholesterol	insulin	MESH:D002784	3630	Chemical	Gene	LDL|compound|START_ENTITY LDL|dep|END_ENTITY	Soluble fibre -LRB- Plantago ovata husk -RRB- reduces plasma low-density lipoprotein -LRB- LDL -RRB- cholesterol , triglycerides , insulin , oxidised LDL and systolic blood pressure in hypercholesterolaemic patients : A randomised trial .
20514688	1	cholesterol	145,156	insulin	92,99	cholesterol	insulin	MESH:D002784	3630	Chemical	Gene	imbalance|compound|START_ENTITY effects|nmod|imbalance effects|nmod|resistance resistance|compound|END_ENTITY	Antidiabetogenic effects of chromium_mitigate hyperinsulinemia-induced cellular insulin resistance via correction of plasma membrane cholesterol imbalance .
20715971	0	cholesterol	42,53	insulin	77,84	cholesterol	insulin	MESH:D002784	3630	Chemical	Gene	ratio|compound|START_ENTITY fails|nsubj|ratio fails|xcomp|predict predict|dobj|resistance resistance|compound|END_ENTITY	The triglyceride/high-density lipoprotein cholesterol ratio fails to predict insulin resistance in African-American women : an analysis of Jackson Heart Study .
21528471	2	cholesterol	403,414	insulin	454,461	cholesterol	insulin	MESH:D002784	3630	Chemical	Gene	children|appos|START_ENTITY HDL-cholesterol|nsubj|children measured|advcl|HDL-cholesterol measured|nsubjpass|END_ENTITY	MATERIAL AND METHODS : In 78 obese children -LRB- 42 girls , 36 boys -RRB- , mean age 14.6 3.5 years , blood pressure , total cholesterol , triglycerides , HDL-cholesterol -LRB- HDL -RRB- , insulin and glucose at fasting state as well as in OGTT were measured .
21730284	0	cholesterol	24,35	insulin	60,67	cholesterol	insulin	MESH:D002784	3630	Chemical	Gene	ratio|compound|START_ENTITY ratio|dep|association association|nmod|resistance resistance|compound|END_ENTITY	The triglyceride-to-HDL cholesterol ratio : association with insulin resistance in obese youths of different ethnic backgrounds .
22420553	0	cholesterol	19,30	insulin	42,49	cholesterol	insulin	MESH:D002784	3630	Chemical	Gene	changes|compound|START_ENTITY changes|nmod|END_ENTITY	Effect of cellular cholesterol changes on insulin secretion by tumor cell lines .
230061	0	cholesterol	143,154	insulin	26,33	cholesterol	insulin	MESH:D002784	3630	Chemical	Gene	concentration|compound|START_ENTITY matched|nmod|concentration controls|acl|matched survivors|nmod|controls END_ENTITY|nmod|survivors	Glucose tolerance , plasma insulin and alpha-lipoproteins in young male myocardial_infarction survivors compared with controls matched on serum cholesterol concentration .
24267726	0	cholesterol	21,32	insulin	94,101	cholesterol	insulin	MESH:D002784	3630	Chemical	Gene	Metabolism|nmod|START_ENTITY related|nsubjpass|Metabolism related|nmod|degree degree|nmod|sensitivity sensitivity|compound|END_ENTITY	Metabolism of plasma cholesterol and lipoprotein parameters are related to a higher degree of insulin sensitivity in high HDL-C healthy normal weight subjects .
24824245	0	cholesterol	69,80	insulin	123,130	cholesterol	insulin	MESH:D002784	3630	Chemical	Gene	triglycerides|nmod|START_ENTITY Triglycerides|nmod|triglycerides better|nsubj|Triglycerides better|ccomp|identify identify|dobj|resistance resistance|compound|END_ENTITY	Triglycerides and ratio of triglycerides to high-density lipoprotein cholesterol are better than liver enzymes to identify insulin resistance in urban middle-aged and older non-obese Chinese without diabetes .
2698352	0	cholesterol	62,73	insulin	4,11	cholesterol	insulin	MESH:D002784	3630	Chemical	Gene	concentrations|nmod|START_ENTITY response|appos|concentrations response|compound|END_ENTITY	The insulin response to oral glucose , concentrations of total cholesterol , triglycerides and uric_acid in women with idiopathic_hirsutism .
2702919	0	cholesterol	43,54	insulin	97,104	cholesterol	insulin	MESH:D002784	3630	Chemical	Gene	control|nmod|START_ENTITY achieve|dobj|control achieve|nmod|infusion infusion|compound|END_ENTITY	Failure to achieve tight control of plasma cholesterol and apolipoprotein_B with intraperitoneal insulin infusion in type 1 diabetes .
3288227	0	cholesterol	40,51	insulin	100,107	cholesterol	insulin	MESH:D002784	3630	Chemical	Gene	metabolism|compound|START_ENTITY control|nmod|metabolism mechanism|nmod|control Testing|dep|mechanism Testing|dep|relation relation|nmod|END_ENTITY	Testing a mechanism of control in human cholesterol metabolism : relation of arginine and glycine to insulin and glucagon .
3311719	0	cholesterol	33,44	insulin	122,129	cholesterol	insulin	MESH:D002784	3630	Chemical	Gene	side-chain|compound|START_ENTITY Modulation|nmod|side-chain cleavage|nsubj|Modulation cleavage|nmod|END_ENTITY	Modulation of aromatase and P450 cholesterol side-chain cleavage enzyme activities of human placental cytotrophoblasts by insulin and insulin-like_growth_factor_I .
3893447	0	cholesterol	110,121	insulin	56,63	cholesterol	insulin	MESH:D002784	3630	Chemical	Gene	Evidence|nmod|START_ENTITY Evidence|nmod|relationship relationship|nmod|END_ENTITY	Evidence for an independent relationship between plasma insulin and concentration of high density lipoprotein cholesterol and triglyceride .
416430	0	cholesterol	66,77	insulin	10,17	cholesterol	insulin	MESH:D002784	100009181(Tax:9986)	Chemical	Gene	induction|nmod|START_ENTITY END_ENTITY|nmod|induction	Effect of insulin in the induction and regression of experimental cholesterol atherosclerosis in the rabbit .
8215234	0	cholesterol	25,36	insulin	138,145	cholesterol	insulin	MESH:D002784	3630	Chemical	Gene	concentrations|compound|START_ENTITY concentrations|dep|relationships relationships|nmod|levels levels|compound|END_ENTITY	High-density lipoprotein cholesterol concentrations and postheparin hepatic and lipoprotein lipases in obesity : relationships with plasma insulin levels .
8222114	1	cholesterol	128,139	insulin	56,63	cholesterol	insulin	MESH:D002784	3630	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of insulin in associations of alcohol intake with high-density lipoprotein cholesterol and triglycerides .
885603	0	cholesterol	27,38	insulin	10,17	cholesterol	insulin	MESH:D002784	483665(Tax:9615)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of insulin on blood cholesterol .
8957207	0	cholesterol	24,35	insulin	13,20	cholesterol	insulin	MESH:D002784	3630	Chemical	Gene	removal|compound|START_ENTITY END_ENTITY|nmod|removal	Influence of insulin on cholesterol removal from macrophages and cholesterol_ester uptake by HepG2 cells .
9125300	0	cholesterol	49,60	insulin	12,19	cholesterol	insulin	MESH:D002784	3630	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	High plasma insulin is associated with lower LDL cholesterol in elderly individuals .
9666194	0	cholesterol	29,40	insulin	53,60	cholesterol	insulin	MESH:D002784	3630	Chemical	Gene	association|nmod|START_ENTITY association|nmod|END_ENTITY	Inverse association of serum cholesterol with plasma insulin in the elderly .
16198427	0	cholesterol	5,16	interleukin-6	57,70	cholesterol	interleukin-6	MESH:D002784	16193(Tax:10090)	Chemical	Gene	results|compound|START_ENTITY results|acl|END_ENTITY	High cholesterol diet results in increased expression of interleukin-6 and caspase-1 in the brain of apolipoprotein_E knockout and wild_type mice .
3580386	0	cholesterol	19,30	lecithin-cholesterol_acyltransferase	56,92	cholesterol	lecithin-cholesterol acyltransferase	MESH:D002784	100126664(Tax:9555)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|amod|END_ENTITY	Effects of dietary cholesterol and fat , sex and sire on lecithin-cholesterol_acyltransferase activity in baboons .
10388470	0	cholesterol	68,79	lipoprotein_lipase	4,22	cholesterol	lipoprotein lipase	MESH:D002784	4023	Chemical	Gene	association|nmod|START_ENTITY polymorphism|dep|association polymorphism|amod|END_ENTITY	The lipoprotein_lipase HindIII polymorphism : association with total cholesterol and LDL-cholesterol , but not with HDL and triglycerides in 342 females .
10998457	0	cholesterol	103,114	lipoprotein_lipase	136,154	cholesterol	lipoprotein lipase	MESH:D002784	24539(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY increases|dobj|levels increases|advcl|increasing increasing|dobj|activity activity|amod|END_ENTITY	Cilostazol , a selective type III phosphodiesterase inhibitor , decreases triglyceride and increases HDL cholesterol levels by increasing lipoprotein_lipase activity in rats .
11730816	0	cholesterol	98,109	lipoprotein_lipase	13,31	cholesterol	lipoprotein lipase	MESH:D002784	4023	Chemical	Gene	tracking|nmod|START_ENTITY polymorphism|nmod|tracking serine|dobj|polymorphism serine|nsubj|Influence Influence|nmod|END_ENTITY	Influence of lipoprotein_lipase serine 447 stop polymorphism on tracking of triglycerides and HDL cholesterol from childhood to adulthood and familial risk of coronary_artery_disease : the Bogalusa heart study .
12169766	0	cholesterol	91,102	lipoprotein_lipase	13,31	cholesterol	lipoprotein lipase	MESH:D002784	24539(Tax:10116)	Chemical	Gene	drug|amod|START_ENTITY atorvastatin|appos|drug preadipocytes|nmod|atorvastatin preadipocytes|nsubj|Induction Induction|nmod|expression expression|amod|END_ENTITY	Induction of lipoprotein_lipase gene expression in 3T3-L1 preadipocytes by atorvastatin , a cholesterol - and triglyceride-lowering drug .
16755277	0	cholesterol	77,88	lipoprotein_lipase	18,36	cholesterol	lipoprotein lipase	MESH:D002784	4023	Chemical	Gene	response|compound|START_ENTITY influence|dobj|response influence|nsubj|Haplotypes Haplotypes|nmod|gene gene|amod|END_ENTITY	Haplotypes in the lipoprotein_lipase gene influence high-density lipoprotein cholesterol response to statin therapy and progression of atherosclerosis in coronary artery bypass grafts .
21756896	0	cholesterol	76,87	lipoprotein_lipase	14,32	cholesterol	lipoprotein lipase	MESH:D002784	24539(Tax:10116)	Chemical	Gene	serum|dobj|START_ENTITY serum|nsubj|Activation Activation|nmod|increases increases|amod|END_ENTITY	Activation of lipoprotein_lipase increases serum high density lipoprotein 2 cholesterol and enlarges high density lipoprotein 2 particles in rats .
25017912	0	cholesterol	63,74	lipoprotein_lipase	19,37	cholesterol	lipoprotein lipase	MESH:D002784	280843(Tax:9913)	Chemical	Gene	efflux|compound|START_ENTITY increases|dobj|efflux increases|nsubj|Down-regulation Down-regulation|nmod|END_ENTITY	Down-regulation of lipoprotein_lipase increases ABCA1-mediated cholesterol efflux in THP-1 macrophages .
3768386	0	cholesterol	19,30	lipoprotein_lipase	49,67	cholesterol	lipoprotein lipase	MESH:D002784	100126663(Tax:9555)	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of dietary cholesterol on adipose tissue lipoprotein_lipase in the baboon .
7647785	0	cholesterol	73,84	lipoprotein_lipase	2,20	cholesterol	lipoprotein lipase	MESH:D002784	4023	Chemical	Gene	levels|compound|START_ENTITY associated|nmod|levels associated|nsubjpass|mutation mutation|amod|END_ENTITY	A lipoprotein_lipase mutation -LRB- Asn291Ser -RRB- is associated with reduced HDL cholesterol levels in premature atherosclerosis .
7840818	0	cholesterol	163,174	lipoprotein_lipase	22,40	cholesterol	lipoprotein lipase	MESH:D002784	4023	Chemical	Gene	elevation|compound|START_ENTITY cholesterol_acyltransferase|nmod|elevation END_ENTITY|dep|cholesterol_acyltransferase	Effects of alcohol on lipoprotein_lipase , hepatic_lipase , cholesteryl_ester_transfer_protein , and lecithin : cholesterol_acyltransferase in high-density lipoprotein cholesterol elevation .
8326009	0	cholesterol	118,129	lipoprotein_lipase	37,55	cholesterol	lipoprotein lipase	MESH:D002784	24539(Tax:10116)	Chemical	Gene	elevation|nmod|START_ENTITY increases|nmod|elevation increases|dobj|activity activity|amod|END_ENTITY	The novel compound NO-1886 increases lipoprotein_lipase activity with resulting elevation of high density lipoprotein cholesterol , and long-term administration inhibits atherogenesis in the coronary arteries of rats with experimental atherosclerosis .
8343498	0	cholesterol	130,141	lipoprotein_lipase	14,32	cholesterol	lipoprotein lipase	MESH:D002784	4023	Chemical	Gene	concentrations|nmod|START_ENTITY patients|nmod|concentrations Activities|nmod|patients Activities|nmod|END_ENTITY	Activities of lipoprotein_lipase and hepatic_triglyceride_lipase in postheparin plasma of patients with low concentrations of HDL cholesterol .
9102182	0	cholesterol	74,85	lipoprotein_lipase	23,41	cholesterol	lipoprotein lipase	MESH:D002784	4023	Chemical	Gene	levels|compound|START_ENTITY associated|nmod|levels associated|nsubjpass|mutation mutation|nmod|END_ENTITY	Ser447stop mutation in lipoprotein_lipase is associated with elevated HDL cholesterol levels in normolipidemic males .
9202040	0	cholesterol	138,149	lipoprotein_lipase	31,49	cholesterol	lipoprotein lipase	MESH:D002784	16956(Tax:10090)	Chemical	Gene	levels|compound|START_ENTITY reduced|dobj|levels reduced|nsubj|mice mice|acl|expressing expressing|dobj|END_ENTITY	Induced mutant mice expressing lipoprotein_lipase exclusively in muscle have subnormal triglycerides yet reduced high density lipoprotein cholesterol levels in plasma .
22694168	0	cholesterol	40,51	liver-X-receptor	13,29	cholesterol	liver-X-receptor	MESH:D002784	22259(Tax:10090)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of liver-X-receptor on tissue cholesterol , coenzyme Q and dolichol content .
11369170	0	cholesterol	150,161	low-density_lipoprotein_receptor	49,81	cholesterol	low-density lipoprotein receptor	MESH:D002784	3949	Chemical	Gene	ingestion|compound|START_ENTITY independent|nmod|ingestion independent|nsubj|phenotype phenotype|nmod|END_ENTITY	Apolipoprotein-E phenotype and basal activity of low-density_lipoprotein_receptor are independent of changes in plasma lipoprotein subfractions after cholesterol ingestion in Japanese subjects .
11429618	0	cholesterol	102,113	low-density_lipoprotein_receptor	157,189	cholesterol	low-density lipoprotein receptor	MESH:D002784	300438(Tax:10116)	Chemical	Gene	changes|nmod|START_ENTITY changes|nmod|expression expression|amod|END_ENTITY	Activation of IP -LRB- 3 -RRB- - protein_kinase_C-alpha signal transduction pathway precedes the changes of plasma cholesterol , hepatic lipid metabolism and induction of low-density_lipoprotein_receptor expression in 17-beta-oestradiol-treated rats .
11997513	0	cholesterol	176,187	low-density_lipoprotein_receptor	101,133	cholesterol	low-density lipoprotein receptor	MESH:D002784	3949	Chemical	Gene	role|nmod|START_ENTITY role|nmod|transcription transcription|amod|END_ENTITY	Critical role of diacylglycerol - and phospholipid-regulated protein_kinase_C epsilon in induction of low-density_lipoprotein_receptor transcription in response to depletion of cholesterol .
12421837	0	cholesterol	77,88	low-density_lipoprotein_receptor	92,124	cholesterol	low-density lipoprotein receptor	MESH:D002784	16835(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Oxidized fatty_acids promote atherosclerosis only in the presence of dietary cholesterol in low-density_lipoprotein_receptor knockout mice .
15163559	0	cholesterol	107,118	low-density_lipoprotein_receptor	17,49	cholesterol	low-density lipoprotein receptor	MESH:D002784	3949	Chemical	Gene	sequestration|nmod|START_ENTITY induced|nmod|sequestration induced|nsubjpass|Up-regulation Up-regulation|nmod|END_ENTITY	Up-regulation of low-density_lipoprotein_receptor in human hepatocytes is induced by sequestration of free cholesterol in the endosomal/lysosomal compartment .
16495773	0	cholesterol	61,72	low-density_lipoprotein_receptor	142,174	cholesterol	low-density lipoprotein receptor	MESH:D002784	3949	Chemical	Gene	inhibitor|compound|START_ENTITY inhibitor|nmod|effect effect|nmod|expression expression|nmod|END_ENTITY	Pharmacological profile of SMP-797 , a novel acyl-coenzyme_a : cholesterol acyltransferase inhibitor with inducible effect on the expression of low-density_lipoprotein_receptor .
17472705	0	cholesterol	16,27	low-density_lipoprotein_receptor	76,108	cholesterol	low-density lipoprotein receptor	MESH:D002784	16835(Tax:10090)	Chemical	Gene	affect|nsubj|START_ENTITY affect|nmod|mice mice|acl|lacking lacking|dobj|END_ENTITY	Elevated plasma cholesterol does not affect brain Abeta in mice lacking the low-density_lipoprotein_receptor .
17517690	0	cholesterol	123,134	low-density_lipoprotein_receptor	32,64	cholesterol	low-density lipoprotein receptor	MESH:D002784	3949	Chemical	Gene	decreases|nmod|START_ENTITY decreases|dobj|exon exon|compound|END_ENTITY	A common polymorphism decreases low-density_lipoprotein_receptor exon 12 splicing efficiency and associates with increased cholesterol .
18607722	0	cholesterol	28,39	low-density_lipoprotein_receptor	86,118	cholesterol	low-density lipoprotein receptor	MESH:D002784	16835(Tax:10090)	Chemical	Gene	concentrations|nmod|START_ENTITY influenced|nsubjpass|concentrations influenced|nmod|ablation ablation|nmod|END_ENTITY	Brainstem concentrations of cholesterol are not influenced by genetic ablation of the low-density_lipoprotein_receptor .
18640380	0	cholesterol	58,69	low-density_lipoprotein_receptor	110,142	cholesterol	low-density lipoprotein receptor	MESH:D002784	16835(Tax:10090)	Chemical	Gene	fatty_acid|nsubj|START_ENTITY fatty_acid|nmod|mice mice|amod|END_ENTITY	Dietary alpha-cyclodextrin lowers low-density lipoprotein cholesterol and alters plasma fatty_acid profile in low-density_lipoprotein_receptor knockout mice on a high-fat diet .
20028367	0	cholesterol	38,49	low-density_lipoprotein_receptor	90,122	cholesterol	low-density lipoprotein receptor	MESH:D002784	300438(Tax:10116)	Chemical	Gene	homeostasis|compound|START_ENTITY disrupted|dobj|homeostasis disrupted|parataxis|biosynthesis biosynthesis|nsubj|down-regulation down-regulation|nmod|END_ENTITY	Chronic alcohol consumption disrupted cholesterol homeostasis in rats : down-regulation of low-density_lipoprotein_receptor and enhancement of cholesterol biosynthesis pathway in the liver .
22666465	0	cholesterol	98,109	low-density_lipoprotein_receptor	30,62	cholesterol	low-density lipoprotein receptor	MESH:D002784	16835(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY activation|nmod|homeostasis activation|nmod|gene gene|amod|END_ENTITY	Transcriptional activation of low-density_lipoprotein_receptor gene by DJ-1 and effect of DJ-1 on cholesterol homeostasis .
2325562	0	cholesterol	10,21	low-density_lipoprotein_receptor	208,240	cholesterol	low-density lipoprotein receptor	MESH:D002784	3949	Chemical	Gene	biosynthesis|compound|START_ENTITY coenzyme|nsubj|biosynthesis coenzyme|dobj|activity activity|acl|associated associated|nmod|function function|amod|END_ENTITY	Decreased cholesterol biosynthesis in sitosterolemia with xanthomatosis : diminished mononuclear leukocyte 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and enzyme protein associated with increased low-density_lipoprotein_receptor function .
6320632	0	cholesterol	67,78	low-density_lipoprotein_receptor	23,55	cholesterol	low-density lipoprotein receptor	MESH:D002784	3949	Chemical	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|nmod|END_ENTITY	Down-regulation of the low-density_lipoprotein_receptor by dietary cholesterol .
8102942	0	cholesterol	82,93	low-density_lipoprotein_receptor	33,65	cholesterol	low-density lipoprotein receptor	MESH:D002784	3949	Chemical	Gene	levels|compound|START_ENTITY -LSB-|nmod|levels -LSB-|dobj|relation relation|nmod|polymorphism polymorphism|nmod|gene gene|amod|END_ENTITY	-LSB- The relation of polymorphism of low-density_lipoprotein_receptor gene with serum cholesterol levels -RSB- .
8399341	0	cholesterol	99,110	low-density_lipoprotein_receptor	4,36	cholesterol	low-density lipoprotein receptor	MESH:D002784	300438(Tax:10116)	Chemical	Gene	affected|nmod|START_ENTITY affected|nsubjpass|synthesis synthesis|compound|END_ENTITY	The low-density_lipoprotein_receptor and cholesterol synthesis are affected differently by dietary cholesterol in the rat .
8561503	0	cholesterol	14,25	low-density_lipoprotein_receptor	56,88	cholesterol	low-density lipoprotein receptor	MESH:D002784	300438(Tax:10116)	Chemical	Gene	biosynthesis|compound|START_ENTITY Inhibitors|nmod|biosynthesis increase|nsubj|Inhibitors increase|dobj|degradation degradation|amod|END_ENTITY	Inhibitors of cholesterol biosynthesis increase hepatic low-density_lipoprotein_receptor protein degradation .
9244400	0	cholesterol	167,178	low-density_lipoprotein_receptor	107,139	cholesterol	low-density lipoprotein receptor	MESH:D002784	300438(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase unmask transcriptional regulation of hepatic low-density_lipoprotein_receptor gene expression by dietary cholesterol .
9326295	0	cholesterol	29,40	low-density_lipoprotein_receptor	122,154	cholesterol	low-density lipoprotein receptor	MESH:D002784	16835(Tax:10090)	Chemical	Gene	distribution|nmod|START_ENTITY modified|nsubjpass|distribution modified|nmod|membranes membranes|nmod|mice mice|acl|deficient deficient|nmod|END_ENTITY	Transbilayer distribution of cholesterol is modified in brain synaptic plasma membranes of knockout mice deficient in the low-density_lipoprotein_receptor , apolipoprotein_E , or both proteins .
9405278	0	cholesterol	71,82	low-density_lipoprotein_receptor	18,50	cholesterol	low-density lipoprotein receptor	MESH:D002784	3949	Chemical	Gene	metabolism|compound|START_ENTITY level|nmod|metabolism level|amod|END_ENTITY	Effect of reduced low-density_lipoprotein_receptor level on HepG2 cell cholesterol metabolism .
11111096	0	cholesterol	5,16	low_density_lipoprotein_receptor	51,83	cholesterol	low density lipoprotein receptor	MESH:D002784	3949	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|nmod|transport	From cholesterol transport to signal transduction : low_density_lipoprotein_receptor , very low_density_lipoprotein_receptor , and apolipoprotein E receptor-2 .
1429619	0	cholesterol	137,148	low_density_lipoprotein_receptor	101,133	cholesterol	low density lipoprotein receptor	MESH:D002784	100689399	Chemical	Gene	repression|compound|START_ENTITY results|nmod|repression results|nmod|resistance resistance|nmod|END_ENTITY	Expression of 7 alpha-hydroxylase in non-hepatic cells results in liver phenotypic resistance of the low_density_lipoprotein_receptor to cholesterol repression .
1438279	0	cholesterol	111,122	low_density_lipoprotein_receptor	29,61	cholesterol	low density lipoprotein receptor	MESH:D002784	3949	Chemical	Gene	pools|compound|START_ENTITY redistribution|nmod|pools regulate|nmod|redistribution regulate|dobj|activity activity|compound|END_ENTITY	Fatty_acids regulate hepatic low_density_lipoprotein_receptor activity through redistribution of intracellular cholesterol pools .
164482	0	cholesterol	94,105	low_density_lipoprotein_receptor	12,44	cholesterol	low density lipoprotein receptor	MESH:D002784	3949	Chemical	Gene	content|nmod|START_ENTITY regulating|dobj|content END_ENTITY|acl|regulating	Role of the low_density_lipoprotein_receptor in regulating the content of free and esterified cholesterol in human fibroblasts .
1674215	0	cholesterol	120,131	low_density_lipoprotein_receptor	17,49	cholesterol	low density lipoprotein receptor	MESH:D002784	3949	Chemical	Gene	levels|compound|START_ENTITY differences|nmod|levels associated|nmod|differences associated|nsubjpass|Variation Variation|nmod|gene gene|compound|END_ENTITY	Variation in the low_density_lipoprotein_receptor gene is associated with differences in plasma low density lipoprotein cholesterol levels in young and old normal individuals from Italy .
221469	0	cholesterol	14,25	low_density_lipoprotein_receptor	101,133	cholesterol	low density lipoprotein receptor	MESH:D002784	3949	Chemical	Gene	synthesis|compound|START_ENTITY Inhibition|nmod|synthesis renders|nsubj|Inhibition renders|xcomp|dependent dependent|nmod|END_ENTITY	Inhibition of cholesterol synthesis with compactin renders growth of cultured cells dependent on the low_density_lipoprotein_receptor .
23135270	0	cholesterol	135,146	low_density_lipoprotein_receptor	92,124	cholesterol	low density lipoprotein receptor	MESH:D002784	16835(Tax:10090)	Chemical	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Furin-cleaved proprotein convertase subtilisin/kexin type 9 -LRB- PCSK9 -RRB- is active and modulates low_density_lipoprotein_receptor and serum cholesterol levels .
2792549	0	cholesterol	33,44	low_density_lipoprotein_receptor	75,107	cholesterol	low density lipoprotein receptor	MESH:D002784	300438(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY effect|nmod|metabolism effect|dep|modulation modulation|nmod|pathway pathway|compound|END_ENTITY	Thymus fraction -LRB- FIII -RRB- effect on cholesterol metabolism : modulation of the low_density_lipoprotein_receptor pathway .
2906577	0	cholesterol	99,110	low_density_lipoprotein_receptor	31,63	cholesterol	low density lipoprotein receptor	MESH:D002784	3949	Chemical	Gene	level|compound|START_ENTITY associated|nmod|level locus|dep|associated locus|nsubj|polymorphism polymorphism|nmod|END_ENTITY	Normal DNA polymorphism at the low_density_lipoprotein_receptor -LRB- LDLR -RRB- locus associated with serum cholesterol level .
3456612	0	cholesterol	97,108	low_density_lipoprotein_receptor	28,60	cholesterol	low density lipoprotein receptor	MESH:D002784	300438(Tax:10116)	Chemical	Gene	flux|compound|START_ENTITY altering|dobj|flux regulate|advcl|altering regulate|dobj|activity activity|compound|END_ENTITY	Bile_acids regulate hepatic low_density_lipoprotein_receptor activity in the hamster by altering cholesterol flux across the liver .
3464957	0	cholesterol	27,38	low_density_lipoprotein_receptor	67,99	cholesterol	low density lipoprotein receptor	MESH:D002784	100009086(Tax:9986)	Chemical	Gene	synthesis|compound|START_ENTITY inhibitor|nmod|synthesis Mevinolin|appos|inhibitor induces|nsubj|Mevinolin induces|dobj|mRNA mRNA|nmod|END_ENTITY	Mevinolin , an inhibitor of cholesterol synthesis , induces mRNA for low_density_lipoprotein_receptor in livers of hamsters and rabbits .
3593342	0	cholesterol	23,34	low_density_lipoprotein_receptor	63,95	cholesterol	low density lipoprotein receptor	MESH:D002784	3949	Chemical	Gene	esterification|compound|START_ENTITY Inhibition|nmod|esterification decrease|nsubj|Inhibition decrease|dobj|number number|compound|END_ENTITY	Inhibition of cellular cholesterol esterification can decrease low_density_lipoprotein_receptor number in human fibroblasts .
4017275	0	cholesterol	103,114	low_density_lipoprotein_receptor	8,40	cholesterol	low density lipoprotein receptor	MESH:D002784	3949	Chemical	Gene	lowering|nmod|START_ENTITY activity|acl|lowering activity|compound|END_ENTITY	Maximal low_density_lipoprotein_receptor activity and the effect of lipid lowering diet on total serum cholesterol .
7356845	0	cholesterol	47,58	low_density_lipoprotein_receptor	78,110	cholesterol	low density lipoprotein receptor	MESH:D002784	3949	Chemical	Gene	Suppression|nmod|START_ENTITY Suppression|nmod|activity activity|compound|END_ENTITY	Suppression of synthesis and esterification of cholesterol and stimulation of low_density_lipoprotein_receptor activity by polyoxyethylated_cholesterol in cultured human fibroblasts .
7883961	0	cholesterol	60,71	low_density_lipoprotein_receptor	12,44	cholesterol	low density lipoprotein receptor	MESH:D002784	16835(Tax:10090)	Chemical	Gene	flux|nmod|START_ENTITY END_ENTITY|nmod|flux	Role of the low_density_lipoprotein_receptor in the flux of cholesterol through the plasma and across the tissues of the mouse .
8098997	0	cholesterol	89,100	low_density_lipoprotein_receptor	32,64	cholesterol	low density lipoprotein receptor	MESH:D002784	3949	Chemical	Gene	levels|compound|START_ENTITY locus|dobj|levels locus|nsubj|variation variation|nmod|END_ENTITY	Normal genetic variation at the low_density_lipoprotein_receptor -LRB- LDLR -RRB- locus influences cholesterol levels in children .
8464893	0	cholesterol	90,101	low_density_lipoprotein_receptor	32,64	cholesterol	low density lipoprotein receptor	MESH:D002784	16835(Tax:10090)	Chemical	Gene	clearance|compound|START_ENTITY accelerates|dobj|clearance accelerates|nsubj|transfer transfer|nmod|gene gene|compound|END_ENTITY	Adenovirus-mediated transfer of low_density_lipoprotein_receptor gene acutely accelerates cholesterol clearance in normal mice .
8969230	0	cholesterol	173,184	low_density_lipoprotein_receptor	93,125	cholesterol	low density lipoprotein receptor	MESH:D002784	3949	Chemical	Gene	levels|compound|START_ENTITY transcription|nmod|levels Identification|acl|transcription Identification|nmod|gene gene|compound|END_ENTITY	Identification of a novel cis-acting element participating in maximal induction of the human low_density_lipoprotein_receptor gene transcription in response to low cellular cholesterol levels .
21876130	0	cholesterol	44,55	mammalian_target_of_rapamycin	4,33	cholesterol	mammalian target of rapamycin	MESH:D002784	2475	Chemical	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The mammalian_target_of_rapamycin regulates cholesterol biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile .
22022489	0	cholesterol	100,111	miR-21	76,82	cholesterol	miR-21	MESH:D002784	100314000(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Expression and localization of microRNAs in perinatal rat pancreas : role of miR-21 in regulation of cholesterol metabolism .
26772887	0	cholesterol	91,102	miR-216a	67,75	cholesterol	miR-216a	MESH:D002784	406998	Chemical	Gene	efflux|compound|START_ENTITY efflux|amod|END_ENTITY	Cystathionine y-lyase -LRB- CSE -RRB- / hydrogen_sulfide system is regulated by miR-216a and influences cholesterol efflux in macrophages via the PI3K/AKT/ABCA1 pathway .
24751522	0	cholesterol	18,29	miR-613	0,7	cholesterol	miR-613	MESH:D002784	693198	Chemical	Gene	efflux|compound|START_ENTITY regulates|dobj|efflux regulates|nsubj|END_ENTITY	miR-613 regulates cholesterol efflux by targeting LXRa and ABCA1 in PPARy activated THP-1 macrophages .
12924933	3	cholesterol	773,784	mice	807,811	cholesterol	VLDL	MESH:D002784	54219(Tax:10090)	Chemical	Gene	levels|compound|START_ENTITY levels|nmod|END_ENTITY	Unexpectedly , the truncated apoE2-202 form that has an R158 for C substitution when expressed at levels similar to those of the full-length apoE2 normalized the cholesterol levels of E-deficient mice without induction of hypertriglyceridemia .
19748796	0	cholesterol	69,80	monocyte_chemoattractant_protein-1	8,42	cholesterol	monocyte chemoattractant protein-1	MESH:D002784	20296(Tax:10090)	Chemical	Gene	upregulated|nmod|START_ENTITY upregulated|nsubjpass|END_ENTITY	Hepatic monocyte_chemoattractant_protein-1 is upregulated by dietary cholesterol and contributes to liver_steatosis .
25797068	0	cholesterol	114,125	monocyte_chemoattractant_protein-1	17,51	cholesterol	monocyte chemoattractant protein-1	MESH:D002784	6347	Chemical	Gene	levels|nmod|START_ENTITY levels|amod|END_ENTITY	Increased plasma monocyte_chemoattractant_protein-1 levels in patients with isolated low high-density lipoprotein cholesterol .
25797068	0	cholesterol	114,125	monocyte_chemoattractant_protein-1	17,51	cholesterol	monocyte chemoattractant protein-1	MESH:D002784	6347	Chemical	Gene	levels|nmod|START_ENTITY levels|amod|END_ENTITY	Increased plasma monocyte_chemoattractant_protein-1 levels in patients with isolated low high-density lipoprotein cholesterol .
8482190	0	cholesterol	87,98	mucin	13,18	cholesterol	mucin	MESH:D002784	100508689	Chemical	Gene	Isolation|nmod|START_ENTITY Isolation|nmod|END_ENTITY	Isolation of mucin from human hepatic bile and its induced effects on precipitation of cholesterol and calcium_carbonate in vitro .
19914203	0	cholesterol	104,115	myelin_basic_protein	62,82	cholesterol	myelin basic protein	MESH:D002784	4155	Chemical	Gene	analog|compound|START_ENTITY presence|nmod|analog END_ENTITY|nmod|presence	Micron-scale phase segregation in lipid monolayers induced by myelin_basic_protein in the presence of a cholesterol analog .
467495	0	cholesterol	40,51	neurotensin	14,25	cholesterol	neurotensin	MESH:D002784	299757(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	The effect of neurotensin on the plasma cholesterol levels in the rat .
6503620	0	cholesterol	50,61	neurotensin	14,25	cholesterol	neurotensin	MESH:D002784	100727527	Chemical	Gene	concentration|nmod|START_ENTITY effect|nmod|concentration effect|nmod|END_ENTITY	The effect of neurotensin on the concentration of cholesterol and bile_acids in the guinea_pig .
7188048	0	cholesterol	53,64	neurotensin	10,21	cholesterol	neurotensin	MESH:D002784	299757(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of neurotensin on specific activity of plasma cholesterol following intravenous administration of cholesterol-4-14C .
22551944	0	cholesterol	12,23	neurotensin_receptor_1	57,79	cholesterol	neurotensin receptor 1	MESH:D002784	4922	Chemical	Gene	role|nmod|START_ENTITY role|nmod|activity activity|nmod|END_ENTITY	The role of cholesterol on the activity and stability of neurotensin_receptor_1 .
2742872	0	cholesterol	12,23	nonspecific_lipid_transfer_protein	57,91	cholesterol	nonspecific lipid transfer protein	MESH:D002784	508918(Tax:9913)	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	Transfer of cholesterol and oxysterol derivatives by the nonspecific_lipid_transfer_protein -LRB- sterol_carrier_protein_2 -RRB- : a study on its mode of action .
11440186	0	cholesterol	41,52	oxytocin_receptor	79,96	cholesterol	oxytocin receptor	MESH:D002784	5021	Chemical	Gene	START_ENTITY|nmod|stimulation stimulation|nmod|END_ENTITY	Molecular modelling study of the role of cholesterol in the stimulation of the oxytocin_receptor .
7595077	0	cholesterol	34,45	p-glycoprotein	127,141	cholesterol	p-glycoprotein	MESH:D002784	5243	Chemical	Gene	Esterification|nmod|START_ENTITY Esterification|dep|role role|nmod|END_ENTITY	Esterification of plasma membrane cholesterol and triacylglycerol-rich lipoprotein secretion in CaCo-2 cells : possible role of p-glycoprotein .
14709354	0	cholesterol	56,67	p27_Kip1	111,119	cholesterol	p27 Kip1	MESH:D002784	12576(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nmod|END_ENTITY	Rapamycin attenuates atherosclerosis induced by dietary cholesterol in apolipoprotein-deficient mice through a p27_Kip1 - independent pathway .
15096274	0	cholesterol	54,65	pancreatic_cholesterol_esterase	14,45	cholesterol	pancreatic cholesterol esterase	MESH:D002784	1056	Chemical	Gene	absorption|compound|START_ENTITY reduces|dobj|absorption reduces|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of pancreatic_cholesterol_esterase reduces cholesterol absorption in the hamster .
26653879	0	cholesterol	131,142	pancreatic_cholesterol_esterase	82,113	cholesterol	pancreatic cholesterol esterase	MESH:D002784	1056	Chemical	Gene	solubility|compound|START_ENTITY extracts|nmod|solubility extracts|nmod|inhibition inhibition|nmod|END_ENTITY	Hypocholesterolaemic mechanism of bitter melon aqueous extracts via inhibition of pancreatic_cholesterol_esterase and reduction of cholesterol micellar solubility .
9148961	0	cholesterol	113,124	pancreatic_cholesterol_esterase	47,78	cholesterol	pancreatic cholesterol esterase	MESH:D002784	1056	Chemical	Gene	uptake|compound|START_ENTITY uptake|amod|END_ENTITY	Phosphatidylcholine hydrolysis is required for pancreatic_cholesterol_esterase - and phospholipase_A2-facilitated cholesterol uptake into intestinal Caco-2 cells .
9213435	0	cholesterol	106,117	pancreatic_cholesterol_esterase	21,52	cholesterol	pancreatic cholesterol esterase	MESH:D002784	1056	Chemical	Gene	absorption|nmod|START_ENTITY cycle|nmod|absorption induction|dep|cycle induction|nmod|END_ENTITY	Dietary induction of pancreatic_cholesterol_esterase : a regulatory cycle for the intestinal absorption of cholesterol .
928399	0	cholesterol	76,87	pancreatic_cholesterol_esterase	8,39	cholesterol	pancreatic cholesterol esterase	MESH:D002784	1056	Chemical	Gene	uptake|nmod|START_ENTITY Role|nmod|uptake Role|nmod|END_ENTITY	Role of pancreatic_cholesterol_esterase in the uptake and esterification of cholesterol by isolated intestinal cells .
22896672	0	cholesterol	8,19	paraoxonase_1	30,43	cholesterol	paraoxonase 1	MESH:D002784	5444	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|activity activity|amod|END_ENTITY	Dietary cholesterol increases paraoxonase_1 enzyme activity .
12615676	0	cholesterol	74,85	peroxisome_proliferator-activated_receptor_delta	14,62	cholesterol	peroxisome proliferator-activated receptor delta	MESH:D002784	5467	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|amod|END_ENTITY	Evidence that peroxisome_proliferator-activated_receptor_delta influences cholesterol metabolism in men .
10194297	0	cholesterol	34,45	phospholipase_A2	100,116	cholesterol	phospholipase A2	MESH:D002784	151056	Chemical	Gene	role|nmod|START_ENTITY Evidence|nmod|role superlattices|nsubj|Evidence superlattices|nmod|activity activity|nmod|END_ENTITY	Evidence for a regulatory role of cholesterol superlattices in the hydrolytic activity of secretory phospholipase_A2 in lipid membranes .
10961723	0	cholesterol	28,39	phospholipase_A2	8,24	cholesterol	phospholipase A2	MESH:D002784	151056	Chemical	Gene	formation|compound|START_ENTITY END_ENTITY|nmod|formation	Role of phospholipase_A2 in cholesterol gallstone formation is associated with biliary phospholipid species selection at the site of hepatic excretion : indirect evidence .
10964164	0	cholesterol	91,102	phospholipase_A2	11,27	cholesterol	phospholipase A2	MESH:D002784	151056	Chemical	Gene	crystallization|nmod|START_ENTITY Effects|nmod|crystallization Effects|nmod|fatty_acids fatty_acids|amod|END_ENTITY	Effects of phospholipase_A2 , free fatty_acids and 2-lysolecithin on the crystallization of cholesterol in gallbladder bile .
12777475	0	cholesterol	75,86	phospholipase_A2	23,39	cholesterol	phospholipase A2	MESH:D002784	18784(Tax:10090)	Chemical	Gene	esterification|compound|START_ENTITY required|nmod|esterification fatty_acids|acl|required supply|dobj|fatty_acids END_ENTITY|xcomp|supply	Oxidized LDL activates phospholipase_A2 to supply fatty_acids required for cholesterol esterification .
18269734	0	cholesterol	22,33	phospholipase_A2	90,106	cholesterol	phospholipase A2	MESH:D002784	151056	Chemical	Gene	Sequestration|nmod|START_ENTITY correlates|nsubj|Sequestration correlates|nmod|activation activation|amod|END_ENTITY	Sequestration of free cholesterol in cell membranes by prions correlates with cytoplasmic phospholipase_A2 activation .
21506137	0	cholesterol	9,20	phospholipase_A2	79,95	cholesterol	phospholipase A2	MESH:D002784	18784(Tax:10090)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|mechanism mechanism|nmod|II II|appos|homologue homologue|amod|END_ENTITY	Membrane cholesterol modulates the cytolytic mechanism of myotoxin II , a Lys49 phospholipase_A2 homologue from the venom of Bothrops asper .
7002548	0	cholesterol	19,30	phospholipase_A2	44,60	cholesterol	phospholipase A2	MESH:D002784	151056	Chemical	Gene	START_ENTITY|nmod|action action|nmod|END_ENTITY	Effect of membrane cholesterol on action of phospholipase_A2 in Mycoplasma mycoides var .
8995259	0	cholesterol	35,46	phospholipase_A2	74,90	cholesterol	phospholipase A2	MESH:D002784	151056	Chemical	Gene	acyltransferase|compound|START_ENTITY determines|nsubj|acyltransferase determines|dobj|specificity specificity|amod|END_ENTITY	Amino_acid residue 149 of lecithin : cholesterol acyltransferase determines phospholipase_A2 and transacylase fatty acyl specificity .
15379211	0	cholesterol	18,29	phospholipase_A2_group_IIA	93,119	cholesterol	phospholipase A2 group IIA	MESH:D002784	5320	Chemical	Gene	accumulation|compound|START_ENTITY accumulation|nmod|END_ENTITY	Increased hepatic cholesterol accumulation in transgenic_mice overexpressing human secretory phospholipase_A2_group_IIA .
16278084	0	cholesterol	27,38	prion_protein	4,17	cholesterol	prion protein	MESH:D002784	5621	Chemical	Gene	requires|dobj|START_ENTITY requires|nsubj|END_ENTITY	The prion_protein requires cholesterol for cell surface localization .
15796514	0	cholesterol	8,19	rhodopsin	111,120	cholesterol	rhodopsin	MESH:D002784	6010	Chemical	Gene	chains|compound|START_ENTITY Role|nmod|chains Role|dep|simulation simulation|nmod|END_ENTITY	Role of cholesterol and polyunsaturated chains in lipid-protein interactions : molecular dynamics simulation of rhodopsin in a realistic membrane environment .
19173312	0	cholesterol	34,45	rhodopsin	85,94	cholesterol	rhodopsin	MESH:D002784	6010	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Structural and dynamic effects of cholesterol at preferred sites of interaction with rhodopsin identified from microsecond length molecular_dynamics simulations .
8841383	0	cholesterol	10,21	rhodopsin	25,34	cholesterol	rhodopsin	MESH:D002784	6010	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|stability stability|compound|END_ENTITY	Effect of cholesterol on rhodopsin stability in disk membranes .
16120612	0	cholesterol	25,36	scavenger_receptor_B-I	56,78	cholesterol	scavenger receptor B-I	MESH:D002784	20778(Tax:10090)	Chemical	Gene	efflux|compound|START_ENTITY efflux|acl|mediated mediated|nmod|END_ENTITY	Serum_amyloid_A promotes cholesterol efflux mediated by scavenger_receptor_B-I .
10964930	0	cholesterol	134,145	scavenger_receptor_BI	158,179	cholesterol	scavenger receptor BI	MESH:D002784	949	Chemical	Gene	START_ENTITY|acl|mediated mediated|nmod|END_ENTITY	High density lipoprotein phospholipid composition is a major determinant of the bi-directional flux and net movement of cellular free cholesterol mediated by scavenger_receptor_BI .
22302708	0	cholesterol	42,53	scavenger_receptor_BI	82,103	cholesterol	scavenger receptor BI	MESH:D002784	20778(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY transport|nmod|END_ENTITY	Chitosan oligosaccharides promote reverse cholesterol transport and expression of scavenger_receptor_BI and CYP7A1 in mice .
12663276	0	cholesterol	112,123	scavenger_receptor_class_B_type_I	48,81	cholesterol	scavenger receptor class B type I	MESH:D002784	949	Chemical	Gene	influence|nmod|START_ENTITY influence|dep|variant variant|nmod|locus locus|nmod|gene gene|amod|END_ENTITY	Polymorphism exon 1 variant at the locus of the scavenger_receptor_class_B_type_I gene : influence on plasma LDL cholesterol in healthy subjects during the consumption of diets with different fat contents .
16133421	0	cholesterol	31,42	scavenger_receptor_class_B_type_I	95,128	cholesterol	scavenger receptor class B type I	MESH:D002784	20778(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|rabbits rabbits|nmod|overexpression overexpression|nmod|END_ENTITY	Increased plasma levels of LDL cholesterol in rabbits after adenoviral overexpression of human scavenger_receptor_class_B_type_I .
17331327	0	cholesterol	78,89	scavenger_receptor_class_B_type_I	12,45	cholesterol	scavenger receptor class B type I	MESH:D002784	20778(Tax:10090)	Chemical	Gene	levels|compound|START_ENTITY raises|dobj|levels raises|nsubj|Blockade Blockade|nmod|END_ENTITY	Blockade of scavenger_receptor_class_B_type_I raises high density lipoprotein cholesterol levels but exacerbates atherosclerotic_lesion formation in apolipoprotein_E deficient mice .
17476110	0	cholesterol	75,86	scavenger_receptor_class_B_type_I	12,45	cholesterol	scavenger receptor class B type I	MESH:D002784	949	Chemical	Gene	levels|compound|START_ENTITY associated|nmod|levels associated|nsubjpass|Variants Variants|nmod|gene gene|amod|END_ENTITY	Variants in scavenger_receptor_class_B_type_I gene are associated with HDL cholesterol levels in younger women .
25868845	0	cholesterol	131,142	scavenger_receptor_class_B_type_I	29,62	cholesterol	scavenger receptor class B type I	MESH:D002784	25073(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY ingestion|nmod|uptake effects|nmod|ingestion inhibitory|dobj|effects contributes|xcomp|inhibitory contributes|nsubj|methylation methylation|nmod|END_ENTITY	Increased DNA methylation of scavenger_receptor_class_B_type_I contributes to inhibitory effects of prenatal caffeine ingestion on cholesterol uptake and steroidogenesis in fetal adrenals .
20979827	0	cholesterol	104,115	serum_amyloid_protein_A1	41,65	cholesterol	serum amyloid protein A1	MESH:D002784	6288	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Association of genetic polymorphisms of serum_amyloid_protein_A1 with plasma high density lipoproteins cholesterol -RSB- .
16757555	0	cholesterol	81,92	sex_hormone-binding_globulin	4,32	cholesterol	sex hormone-binding globulin	MESH:D002784	6462	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	Low sex_hormone-binding_globulin is associated with low high-density lipoprotein cholesterol and metabolic_syndrome in women with PCOS .
18370811	0	cholesterol	30,41	sex_hormone-binding_globulin	82,110	cholesterol	sex hormone-binding globulin	MESH:D002784	6462	Chemical	Gene	program|compound|START_ENTITY Effect|nmod|program step|nsubj|Effect step|dobj|diet diet|nmod|levels levels|compound|END_ENTITY	Effect of a six-week national cholesterol education program step 1 diet on plasma sex_hormone-binding_globulin levels in overweight premenopausal women .
8847489	0	cholesterol	119,130	sterol-carrier_protein-2	46,70	cholesterol	sterol-carrier protein-2	MESH:D002784	6342	Chemical	Gene	trafficking|compound|START_ENTITY trafficking|amod|END_ENTITY	Cholesterol enrichment enhances expression of sterol-carrier_protein-2 : implications for its function in intracellular cholesterol trafficking .
12531903	0	cholesterol	55,66	sterol_27-hydroxylase	14,35	cholesterol	sterol 27-hydroxylase	MESH:D002784	1593	Chemical	Gene	efflux|compound|START_ENTITY enhances|dobj|efflux enhances|nsubj|Expression Expression|nmod|END_ENTITY	Expression of sterol_27-hydroxylase -LRB- CYP27A1 -RRB- enhances cholesterol efflux .
10585416	0	cholesterol	26,37	sterol_carrier_protein-2	75,99	cholesterol	sterol carrier protein-2	MESH:D002784	20280(Tax:10090)	Chemical	Gene	side|compound|START_ENTITY oxidation|nmod|side chain|nsubj|oxidation chain|nmod|synthesis synthesis|nmod|mice mice|amod|END_ENTITY	Aberrant oxidation of the cholesterol side chain in bile_acid synthesis of sterol_carrier_protein-2 / sterol_carrier_protein-x knockout mice .
19289417	0	cholesterol	73,84	sterol_carrier_protein-2	18,42	cholesterol	sterol carrier protein-2	MESH:D002784	20280(Tax:10090)	Chemical	Gene	accumulation|compound|START_ENTITY alters|dobj|accumulation alters|nsubj|Overexpression Overexpression|nmod|differentially differentially|amod|END_ENTITY	Overexpression of sterol_carrier_protein-2 differentially alters hepatic cholesterol accumulation in cholesterol-fed mice .
20395534	0	cholesterol	65,76	sterol_carrier_protein-2	10,34	cholesterol	sterol carrier protein-2	MESH:D002784	20280(Tax:10090)	Chemical	Gene	efflux|compound|START_ENTITY ablation|nmod|efflux ablation|nsubj|Effect Effect|nmod|gene gene|amod|END_ENTITY	Effect of sterol_carrier_protein-2 gene ablation on HDL-mediated cholesterol efflux from cultured primary mouse hepatocytes .
8006511	0	cholesterol	95,106	sterol_carrier_protein-2	24,48	cholesterol	sterol carrier protein-2	MESH:D002784	6342	Chemical	Gene	Lack|nmod|START_ENTITY Lack|nmod|END_ENTITY	Lack of requirement for sterol_carrier_protein-2 in the intracellular trafficking of lysosomal cholesterol .
8011635	0	cholesterol	23,34	sterol_carrier_protein-2	46,70	cholesterol	sterol carrier protein-2	MESH:D002784	6342	Chemical	Gene	Regulation|nmod|START_ENTITY domains|nsubj|Regulation domains|advcl|END_ENTITY	Regulation of membrane cholesterol domains by sterol_carrier_protein-2 .
8760350	0	cholesterol	27,38	sterol_carrier_protein-2	115,139	cholesterol	sterol carrier protein-2	MESH:D002784	25541(Tax:10116)	Chemical	Gene	trafficking|compound|START_ENTITY Modulation|nmod|trafficking Modulation|dep|evidence evidence|nmod|treatment treatment|nmod|involvement involvement|nmod|transport transport|amod|END_ENTITY	Modulation of intrahepatic cholesterol trafficking : evidence by in vivo antisense treatment for the involvement of sterol_carrier_protein-2 in newly synthesized cholesterol transport into rat bile .
10585416	0	cholesterol	26,37	sterol_carrier_protein-x	100,124	cholesterol	sterol carrier protein-x	MESH:D002784	20280(Tax:10090)	Chemical	Gene	side|compound|START_ENTITY oxidation|nmod|side chain|nsubj|oxidation chain|nmod|synthesis synthesis|nmod|mice mice|amod|END_ENTITY	Aberrant oxidation of the cholesterol side chain in bile_acid synthesis of sterol_carrier_protein-2 / sterol_carrier_protein-x knockout mice .
19825216	0	cholesterol	136,147	sterol_regulatory_element_binding_protein	49,90	cholesterol	sterol regulatory element binding protein	MESH:D002784	7555	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	n-3 and n-6 Polyunsaturated fatty_acids suppress sterol_regulatory_element_binding_protein activity and increase flow of non-esterified cholesterol in HepG2 cells .
20716909	0	cholesterol	194,205	superoxide_dismutase	132,152	cholesterol	superoxide dismutase	MESH:D002784	6647	Chemical	Gene	reduction|nmod|START_ENTITY increasing|nmod|reduction increasing|dobj|END_ENTITY	Oral administration of L-arginine in patients with angina or following myocardial_infarction may be protective by increasing plasma superoxide_dismutase and total thiols with reduction in serum cholesterol and xanthine oxidase .
8293516	0	cholesterol	11,22	superoxide_dismutase	116,136	cholesterol	superoxide dismutase	MESH:D002784	6647	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of cholesterol on the miscibility of synthetic glucosamine_diesters in lipid bilayers and the entrapment of superoxide_dismutase into the positively charged liposomes .
6289872	1	cholesterol	72,83	transferrin	102,113	cholesterol	transferrin	MESH:D002784	100009267(Tax:9986)	Chemical	Gene	START_ENTITY|nmod|the the|nmod|END_ENTITY	Effect of cholesterol on the binding of transferrin .
24814875	0	cholesterol	80,91	translocator_protein	31,51	cholesterol	translocator protein	MESH:D002784	706	Chemical	Gene	efflux|compound|START_ENTITY regulates|dobj|efflux regulates|nsubj|END_ENTITY	Targeting mitochondrial 18 kDa translocator_protein -LRB- TSPO -RRB- regulates macrophage cholesterol efflux and lipid phenotype .
12529448	0	cholesterol	103,114	vascular_endothelial_growth_factor_receptor-2	14,59	cholesterol	vascular endothelial growth factor receptor-2	MESH:D002784	3791	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|activity activity|amod|END_ENTITY	Regulation of vascular_endothelial_growth_factor_receptor-2 activity by caveolin-1 and plasma membrane cholesterol .
19429425	0	cholesterol	6,17	vitamin_D_receptor	65,83	cholesterol	vitamin D receptor	MESH:D002784	22337(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Serum cholesterol and expression of ApoAI , LXRbeta and SREBP2 in vitamin_D_receptor knock-out mice .
17545668	0	cholesterol_3-sulfate	40,61	galectin-4	25,35	cholesterol 3-sulfate	galectin-4	null	3960	Chemical	Gene	mechanism|nmod|START_ENTITY mechanism|nmod|END_ENTITY	Recognition mechanism of galectin-4 for cholesterol_3-sulfate .
12708757	0	cholesterol_ester	61,78	CETP	97,101	cholesterol ester	CETP	CHEBI:17002	100327267(Tax:9986)	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Characterization of a naturally occurring new version of the cholesterol_ester transfer protein -LRB- CETP -RRB- from small intestine .
14608418	0	cholesterol_ester	35,52	CETP	141,145	cholesterol ester	CETP	CHEBI:17002	1071	Chemical	Gene	protein|compound|START_ENTITY increase|nmod|protein increase|acl|expressing expressing|dobj|END_ENTITY	Streptozotocin-induced increase in cholesterol_ester transfer protein -LRB- CETP -RRB- and its reversal by insulin in transgenic_mice expressing human CETP .
14608418	0	cholesterol_ester	35,52	CETP	71,75	cholesterol ester	CETP	CHEBI:17002	1071	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Streptozotocin-induced increase in cholesterol_ester transfer protein -LRB- CETP -RRB- and its reversal by insulin in transgenic_mice expressing human CETP .
22143414	0	cholesterol_ester	21,38	CETP	63,67	cholesterol ester	CETP	CHEBI:17002	1071	Chemical	Gene	protein|compound|START_ENTITY variation|nmod|protein END_ENTITY|nsubj|variation	Genetic variation in cholesterol_ester transfer protein , serum CETP activity , and coronary_artery_disease risk in Asian_Indian_diabetic_cohort .
25120972	2	cholesterol_ester	359,376	CETP	322,326	cholesterol ester	CETP	CHEBI:17002	1071	Chemical	Gene	transfer|nmod|START_ENTITY essential|nmod|transfer VLDL|amod|essential VLDL|nsubj|END_ENTITY	CETP is an essential for transfer of cholesterol_ester to the liver from peripheral tissues which facilitating its transfer to TG rich VLDL .
8076182	0	cholesterol_ester	29,46	CETP	23,27	cholesterol ester	CETP	CHEBI:17002	1071	Chemical	Gene	protein|amod|START_ENTITY END_ENTITY|appos|protein	-LSB- Lipoprotein_Lp -LRB- a -RRB- and CETP -LRB- cholesterol_ester transfer protein -RRB- : contribution of transgenic_mice -RSB- .
10652987	0	cholesterol_ester	78,95	high_density_lipoprotein-3	44,70	cholesterol ester	high density lipoprotein-3	CHEBI:17002	53369	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|nmod|protein	Effect of the nonenzymatic glycosylation of high_density_lipoprotein-3 on the cholesterol_ester transfer protein activity .
22354961	0	cholesterol_ester	53,70	p38_mitogen-activated_protein_kinase	0,36	cholesterol ester	p38 mitogen-activated protein kinase	CHEBI:17002	1432	Chemical	Gene	accumulation|compound|START_ENTITY promotes|dobj|accumulation promotes|nsubj|END_ENTITY	p38_mitogen-activated_protein_kinase -LRB- MAPK -RRB- promotes cholesterol_ester accumulation in macrophages through inhibition of macroautophagy .
11564720	0	cholesterol_esters	69,87	Angiotensin_II	0,14	cholesterol esters	Angiotensin II	MESH:D002788	183	Chemical	Gene	uptake|nmod|START_ENTITY promotes|dobj|uptake promotes|nsubj|END_ENTITY	Angiotensin_II promotes selective uptake of high density lipoprotein cholesterol_esters in bovine adrenal glomerulosa and human adrenocortical_carcinoma cells through induction of scavenger receptor class B type I. Angiotensin_II is one of the main physiological regulators of aldosterone biosynthesis in the zona glomerulosa of the adrenal cortex .
10085133	0	cholesterol_esters	64,82	Scavenger_receptor_BI	0,21	cholesterol esters	Scavenger receptor BI	MESH:D002788	25073(Tax:10116)	Chemical	Gene	uptake|nmod|START_ENTITY mediates|dobj|uptake mediates|nsubj|END_ENTITY	Scavenger_receptor_BI mediates the selective uptake of oxidized cholesterol_esters by rat liver .
18494281	0	cholesterol_ethers	72,90	lipoprotein-lipase	30,48	cholesterol ethers	lipoprotein-lipase	null	4023	Chemical	Gene	protein|nmod|START_ENTITY protein|compound|END_ENTITY	-LSB- The relation between gene of lipoprotein-lipase and carrier protein of cholesterol_ethers and life duration in patients with chronic_cerebral_ischemia -RSB- .
25865416	0	cholesterol_hydroperoxides	25,51	Cytochrome_c	0,12	cholesterol hydroperoxides	Cytochrome c	null	54205	Chemical	Gene	reacts|nmod|START_ENTITY reacts|nsubj|END_ENTITY	Cytochrome_c reacts with cholesterol_hydroperoxides producing lipid - and protein-derived radicals .
1388820	0	cholesterol_linoleate	16,37	cholesterol_esterase	70,90	cholesterol linoleate	cholesterol esterase	null	1056	Chemical	Gene	Biosynthesis|nmod|START_ENTITY Biosynthesis|nmod|END_ENTITY	Biosynthesis of cholesterol_linoleate by polyethylene_glycol-modified cholesterol_esterase in organic solvents .
8864249	0	cholesterol_oxides	21,39	low_density_lipoprotein_receptor	43,75	cholesterol oxides	low density lipoprotein receptor	null	100009086(Tax:9986)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|compound|END_ENTITY	Inhibitory effect of cholesterol_oxides on low_density_lipoprotein_receptor gene expression .
1010843	0	cholesterol_sulfate	10,29	lecithin-cholesterol_acyltransferase	60,96	cholesterol sulfate	lecithin-cholesterol acyltransferase	MESH:C007045	3931	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of cholesterol_sulfate and sodium_dodecyl_sulfate on lecithin-cholesterol_acyltransferase in human plasma .
11934392	0	cholesteryl	62,73	cholesteryl_ester_transfer_protein	82,116	cholesteryl	cholesteryl ester transfer protein	null	1071	Chemical	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	The essential role of a free sulfhydryl group in blocking the cholesteryl site of cholesteryl_ester_transfer_protein -LRB- CETP -RRB- .
9609240	0	cholesteryl-hemisuccinate	44,69	CD36	15,19	cholesteryl-hemisuccinate	CD36	MESH:C013440	948	Chemical	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	Human platelet CD36 -LRB- GPIIIb , GPIV -RRB- binds to cholesteryl-hemisuccinate and can be purified by a simple two-step method making use of this property .
17438337	0	cholesteryl_ester	17,34	ACAT2	0,5	cholesteryl ester	ACAT2	null	39	Chemical	Gene	secretion|compound|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	ACAT2 stimulates cholesteryl_ester secretion in apoB-containing lipoproteins .
18669886	0	cholesteryl_ester	73,90	APOE	111,115	cholesteryl ester	APOE	null	11816(Tax:10090)	Chemical	Gene	protein|compound|START_ENTITY protein|nmod|END_ENTITY	Niacin increases HDL by reducing hepatic expression and plasma levels of cholesteryl_ester transfer protein in APOE * 3Leiden .
14993244	3	cholesteryl_ester	348,365	CETP	384,388	cholesteryl ester	LDLR	null	16835(Tax:10090)	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	However , mice do not express cholesteryl_ester transfer protein -LRB- CETP -RRB- , which is involved in the same metabolic pathways as PLTP .
15339254	0	cholesteryl_ester	69,86	CETP	105,109	cholesteryl ester	CETP	null	1071	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Apolipoprotein_CI overexpression is not a relevant strategy to block cholesteryl_ester transfer protein -LRB- CETP -RRB- activity in CETP transgenic_mice .
16822236	0	cholesteryl_ester	6,23	CETP	0,4	cholesteryl ester	CETP	null	1071	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|dep|protein	CETP -LRB- cholesteryl_ester transfer protein -RRB- promoter -1337 _ C > T polymorphism protects against coronary_atherosclerosis in Japanese patients with heterozygous familial_hypercholesterolaemia .
26477338	0	cholesteryl_ester	42,59	CETP	78,82	cholesteryl ester	CETP	D002788	1071	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Functional and association studies of the cholesteryl_ester transfer protein -LRB- CETP -RRB- gene in a Wannan Black pig model .
15528479	0	cholesteryl_ester	103,120	Scavenger_receptor_class_B_type_I	0,33	cholesteryl ester	Scavenger receptor class B type I	null	20778(Tax:10090)	Chemical	Gene	uptake|nmod|START_ENTITY mediates|dobj|uptake mediates|nsubj|END_ENTITY	Scavenger_receptor_class_B_type_I mediates the selective uptake of high-density lipoprotein-associated cholesteryl_ester by the liver in mice .
10484611	0	cholesteryl_ester	92,109	THP-1	120,125	cholesteryl ester	THP-1	null	2736	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|macrophages macrophages|compound|END_ENTITY	Co-expression of scavenger receptor-BI and caveolin-1 is associated with enhanced selective cholesteryl_ester uptake in THP-1 macrophages .
11742878	0	cholesteryl_ester	53,70	Transforming_growth_factor-beta1	0,32	cholesteryl ester	Transforming growth factor-beta1	null	7040	Chemical	Gene	accumulation|compound|START_ENTITY inhibits|dobj|accumulation inhibits|nsubj|END_ENTITY	Transforming_growth_factor-beta1 inhibits macrophage cholesteryl_ester accumulation induced by native and oxidized VLDL remnants .
12473673	0	cholesteryl_ester	68,85	apolipoprotein_A-I	144,162	cholesteryl ester	apolipoprotein A-I	null	11806(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|END_ENTITY	Enhancement of scavenger_receptor_class_B_type_I-mediated selective cholesteryl_ester uptake from apoA-I -LRB- - / - -RRB- high density lipoprotein -LRB- HDL -RRB- by apolipoprotein_A-I requires HDL reorganization by lecithin_cholesterol_acyltransferase .
1911715	0	cholesteryl_ester	92,109	apolipoprotein_A-I	157,175	cholesteryl ester	apolipoprotein A-I	null	335	Chemical	Gene	START_ENTITY|nmod|transgenic_mice transgenic_mice|compound|END_ENTITY	Probucol decreases apolipoprotein_A-I transport rate and increases high density lipoprotein cholesteryl_ester fractional catabolic rate in control and human apolipoprotein_A-I transgenic_mice .
22700792	0	cholesteryl_ester	40,57	carboxylesterase_3	69,87	cholesteryl ester	carboxylesterase 3	null	23491	Chemical	Gene	hydrolase|compound|START_ENTITY hydrolase|appos|END_ENTITY	Identification of a novel intracellular cholesteryl_ester hydrolase -LRB- carboxylesterase_3 -RRB- in human macrophages : compensatory increase in its expression after carboxylesterase_1 silencing .
19464305	0	cholesteryl_ester	101,118	cholesterol_esterase	42,62	cholesteryl ester	cholesterol esterase	null	1056	Chemical	Gene	Effects|acl|START_ENTITY Effects|nmod|END_ENTITY	Effects of oxidation on the hydrolysis by cholesterol_esterase of sitosteryl_esters as compared to a cholesteryl_ester .
1464752	0	cholesteryl_ester	126,143	hepatic_lipase	94,108	cholesteryl ester	hepatic lipase	null	24538(Tax:10116)	Chemical	Gene	uptake|nmod|START_ENTITY END_ENTITY|nmod|uptake	Metabolism of high density lipoprotein lipids by the rat liver : evidence for participation of hepatic_lipase in the uptake of cholesteryl_ester .
20431066	0	cholesteryl_ester	50,67	scavenger_receptor_class_B_type_I	99,132	cholesteryl ester	scavenger receptor class B type I	null	20778(Tax:10090)	Chemical	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Restoration of high-density lipoprotein levels by cholesteryl_ester transfer protein expression in scavenger_receptor_class_B_type_I -LRB- SR-BI -RRB- knockout mice does not normalize pathologies associated with SR-BI_deficiency .
15805543	0	cholesteryl_esters	18,36	ACAT2	0,5	cholesteryl esters	ACAT2	MESH:D002788	110460(Tax:10090)	Chemical	Gene	contributes|dobj|START_ENTITY contributes|nsubj|END_ENTITY	ACAT2 contributes cholesteryl_esters to newly secreted VLDL , whereas LCAT adds cholesteryl_ester to LDL in mice .
11893779	0	cholesteryl_esters	61,79	LCAT	24,28	cholesteryl esters	LCAT	MESH:D002788	16816(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|contribution contribution|nmod|END_ENTITY	In vivo contribution of LCAT to apolipoprotein_B lipoprotein cholesteryl_esters in LDL_receptor and apolipoprotein_E knockout mice .
8645354	0	cholesteryl_esters	49,67	THP-1	78,83	cholesteryl esters	THP-1	MESH:D002788	2736	Chemical	Gene	START_ENTITY|nmod|macrophages macrophages|appos|END_ENTITY	Impaired mobilisation of cholesterol from stored cholesteryl_esters in human -LRB- THP-1 -RRB- macrophages .
15231851	0	cholesteryl_esters	91,109	cholesteryl_ester_transfer_protein	8,42	cholesteryl esters	cholesteryl ester transfer protein	MESH:D002788	1071	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of cholesteryl_ester_transfer_protein in selective uptake of high density lipoprotein cholesteryl_esters by adipocytes .
12615696	0	cholesteryl_esters	124,142	peroxisome_proliferator-activated_receptor_gamma	14,62	cholesteryl esters	peroxisome proliferator-activated receptor gamma	MESH:D002788	19016(Tax:10090)	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of peroxisome_proliferator-activated_receptor_gamma and retinoid X receptor results in net depletion of cellular cholesteryl_esters in macrophages exposed to oxidized lipoproteins .
9525955	0	cholesteryl_esters	97,115	scavenger_receptor_BI	22,43	cholesteryl esters	scavenger receptor BI	MESH:D002788	25073(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	In vivo regulation of scavenger_receptor_BI and the selective uptake of high density lipoprotein cholesteryl_esters in rat liver parenchymal and Kupffer cells .
2333465	0	cholesteryl_hemisuccinate	78,103	serum_amyloid_A_protein	45,68	cholesteryl hemisuccinate	serum amyloid A protein	MESH:C013440	6288	Chemical	Gene	chromatography|amod|START_ENTITY Purification|nmod|chromatography Purification|nmod|END_ENTITY	Purification and characterization of hamster serum_amyloid_A_protein -LRB- SAA -RRB- by cholesteryl_hemisuccinate affinity chromatography .
2090716	0	cholestyramine	79,93	HMG-CoA_reductase	97,114	cholestyramine	HMG-CoA reductase	null	3156	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Regulation of hepatic cholesterol metabolism in humans : stimulatory effects of cholestyramine on HMG-CoA_reductase activity and low_density_lipoprotein_receptor expression in gallstone patients .
17005160	0	cholestyramine	29,43	K-ras	9,14	cholestyramine	K-ras	null	16653(Tax:10090)	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Elevated K-ras activity with cholestyramine and lovastatin , but not konjac mannan or niacin in lung -- importance of mouse strain .
1557341	0	cholestyramine	23,37	cholecystokinin	78,93	cholestyramine	cholecystokinin	null	25298(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nsubj|effect	Chronic effect of oral cholestyramine , a bile_salt sequestrant , and exogenous cholecystokinin on insulin release in rats .
1984567	0	cholestyramine	68,82	familial_hypercholesterolemia	86,115	cholestyramine	familial hypercholesterolemia	null	3949	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Hypolipidemic effect and mechanism of ketoconazole without and with cholestyramine in familial_hypercholesterolemia .
7488206	0	cholic_acid	73,84	CYP7	39,43	cholic acid	CYP7	MESH:D019826	100328551(Tax:9986)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|nmod|END_ENTITY	Different effects on the expression of CYP7 and CYP27 in rabbit liver by cholic_acid and cholestyramine .
7370273	0	cholic_acid	60,71	oxidoreductase	34,48	cholic acid	oxidoreductase	MESH:D019826	8630	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Characterization of a NADH : flavin oxidoreductase induced by cholic_acid in a 7 alpha-dehydroxylating intestinal Eubacterium species .
12406342	0	choline	32,39	CHT1	53,57	choline	CHT1	MESH:D002794	60482	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Expression of the high-affinity choline transporter , CHT1 , in the neuronal and non-neuronal cholinergic system of human and rat skin .
12654636	0	choline	32,39	CHT1	53,57	choline	CHT1	MESH:D002794	85426(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Expression of the high-affinity choline transporter , CHT1 , in the rat trachea .
15090548	0	choline	15,22	CHT1	50,54	choline	CHT1	MESH:D002794	60482	Chemical	Gene	uptake|amod|START_ENTITY inhibits|dobj|uptake inhibits|advcl|interacting interacting|nmod|END_ENTITY	Par-4 inhibits choline uptake by interacting with CHT1 and reducing its incorporation on the plasma membrane .
15245786	0	choline	25,32	CHT1	45,49	choline	CHT1	MESH:D002794	63993(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY Changes|nmod|transporter END_ENTITY|nsubj|Changes	Changes of high-affinity choline transporter CHT1 mRNA expression during degeneration and regeneration of hypoglossal nerves in mice .
16524384	0	choline	42,49	CHT1	62,66	choline	CHT1	MESH:D002794	60482	Chemical	Gene	transporter|compound|START_ENTITY outs|nmod|transporter END_ENTITY|nsubj|outs	The `` ins '' and `` outs '' of the high-affinity choline transporter CHT1 .
21337021	0	choline	25,32	CHT1	51,55	choline	CHT1	MESH:D002794	60482	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphic variation in choline transporter gene -LRB- CHT1 -RRB- is associated with early , subclinical measures of carotid_atherosclerosis in humans .
20410607	0	choline	15,22	CTL1	50,54	choline	CTL1	MESH:D002794	23446	Chemical	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	Involvement of choline transporter-like proteins , CTL1 and CTL2 , in glucocorticoid-induced acceleration of phosphatidylcholine synthesis via increased choline uptake .
22279038	0	choline	105,112	Glycerophosphodiester_phosphodiesterase_domain_containing_5	0,59	choline	Glycerophosphodiester phosphodiesterase domain containing 5	MESH:D002794	81544	Chemical	Gene	correlates|nmod|START_ENTITY correlates|amod|END_ENTITY	Glycerophosphodiester_phosphodiesterase_domain_containing_5 -LRB- GDPD5 -RRB- expression correlates with malignant choline phospholipid metabolite profiles in human breast_cancer .
14608048	0	choline	66,73	Phosphatidylethanolamine-N-methyltransferase	0,44	choline	Phosphatidylethanolamine-N-methyltransferase	MESH:D002794	18618(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|activity activity|amod|END_ENTITY	Phosphatidylethanolamine-N-methyltransferase activity and dietary choline regulate liver-plasma lipid flux and essential fatty_acid metabolism in mice .
11333225	0	choline	43,50	SCS2	64,68	choline	SCS2	MESH:D002794	856856(Tax:4932)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The Saccharomyces_cerevisiae suppressor of choline sensitivity -LRB- SCS2 -RRB- gene is a multicopy Suppressor of mec1 telomeric silencing defects .
18584048	0	choline	29,36	TNF	14,17	choline	TNF	MESH:D002794	21926(Tax:10090)	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|Modulation Modulation|nmod|END_ENTITY	Modulation of TNF release by choline requires alpha7 subunit nicotinic acetylcholine receptor-mediated signaling .
1963253	0	choline	64,71	acetylcholinesterase	91,111	choline	acetylcholinesterase	MESH:D002794	83817(Tax:10116)	Chemical	Gene	uptake|amod|START_ENTITY Changes|amod|uptake Changes|nmod|activity activity|amod|END_ENTITY	Changes in choline_acetyltransferase activity and high-affinity choline uptake , but not in acetylcholinesterase activity and muscarinic cholinergic receptors , in rat somatosensory cortex after sciatic_nerve_injury .
9301662	0	choline	52,59	acetylcholinesterase	87,107	choline	acetylcholinesterase	MESH:D002794	43	Chemical	Gene	Synthesis|nmod|START_ENTITY Synthesis|nmod|inhibitors inhibitors|nmod|END_ENTITY	Synthesis and study of thiocarbonate derivatives of choline as potential inhibitors of acetylcholinesterase .
1573390	0	choline	11,18	choline_acetyltransferase	48,73	choline	choline acetyltransferase	MESH:D002794	42249(Tax:7227)	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of choline and quiescence on Drosophila choline_acetyltransferase expression and acetylcholine production by transduced rat fibroblasts .
1963253	0	choline	64,71	choline_acetyltransferase	11,36	choline	choline acetyltransferase	MESH:D002794	290567(Tax:10116)	Chemical	Gene	uptake|amod|START_ENTITY Changes|amod|uptake Changes|nmod|activity activity|amod|END_ENTITY	Changes in choline_acetyltransferase activity and high-affinity choline uptake , but not in acetylcholinesterase activity and muscarinic cholinergic receptors , in rat somatosensory cortex after sciatic_nerve_injury .
3989571	0	choline	58,65	choline_acetyltransferase	29,54	choline	choline acetyltransferase	MESH:D002794	290567(Tax:10116)	Chemical	Gene	ion|amod|START_ENTITY Studies|nmod|ion Studies|nmod|alkylation alkylation|nmod|END_ENTITY	Studies on the alkylation of choline_acetyltransferase by choline mustard aziridinium ion .
454930	0	choline	68,75	choline_acetyltransferase	15,40	choline	choline acetyltransferase	MESH:D002794	100342226(Tax:9986)	Chemical	Gene	slices|amod|START_ENTITY metabolism|nmod|slices The|dep|metabolism The|nmod|END_ENTITY	The binding of choline_acetyltransferase to membrane ; metabolism of choline in rabbit cortical slices -LSB- proceedings -RSB- .
8592155	0	choline	106,113	choline_acetyltransferase	61,86	choline	choline acetyltransferase	MESH:D002794	290567(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY transport|compound|END_ENTITY	Differential effects of nerve_growth_factor on expression of choline_acetyltransferase and sodium-coupled choline transport in basal forebrain cholinergic neurons in culture .
880468	0	choline	67,74	choline_acetyltransferase	23,48	choline	choline acetyltransferase	MESH:D002794	290567(Tax:10116)	Chemical	Gene	uptake|amod|START_ENTITY uptake|amod|END_ENTITY	Effect of reserpine on choline_acetyltransferase and high affinity choline uptake in the rat brain -LSB- proceedings -RSB- .
3899120	0	choline	51,58	choline_dehydrogenase	26,47	choline	choline dehydrogenase	MESH:D002794	218865(Tax:10090)	Chemical	Gene	metabolism|amod|START_ENTITY END_ENTITY|nmod|metabolism	The effects of inhibiting choline_dehydrogenase on choline metabolism in mice .
639755	0	choline	31,38	growth_hormone	42,56	choline	growth hormone	MESH:D002794	2688	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Effect of cytidine diphosphate choline on growth_hormone and prolactin secretion in man .
7439117	0	choline	31,38	growth_hormone	42,56	choline	growth hormone	MESH:D002794	2688	Chemical	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	Effect of cytidine diphosphate choline on growth_hormone secretion in patients with brain or pituitary_lesions .
17005849	0	choline	41,48	hCHT	62,66	choline	hCHT	MESH:D002794	60482	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Na + , Cl - , and pH dependence of the human choline transporter -LRB- hCHT -RRB- in Xenopus oocytes : the proton inactivation hypothesis of hCHT in synaptic vesicles .
2381575	0	choline	61,68	nerve_growth_factor	107,126	choline	nerve growth factor	MESH:D002794	310738(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY activity|acl|induced induced|nmod|END_ENTITY	Basic_fibroblast_growth_factor suppressed the enhancement of choline acetyltransferase activity induced by nerve_growth_factor .
2384747	0	choline	70,77	nerve_growth_factor	10,29	choline	nerve growth factor	MESH:D002794	310738(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY activity|nmod|uptake increases|dobj|activity increases|nsubj|END_ENTITY	Exogenous nerve_growth_factor increases the activity of high-affinity choline uptake and choline_acetyltransferase in brain of Fisher 344 male rats .
2713652	0	choline	136,143	nerve_growth_factor	20,39	choline	nerve growth factor	MESH:D002794	310738(Tax:10116)	Chemical	Gene	decrease|compound|START_ENTITY preventing|dobj|decrease monosialoganglioside|advcl|preventing monosialoganglioside|nsubj|Interaction Interaction|nmod|END_ENTITY	Interaction between nerve_growth_factor and GM1 monosialoganglioside in preventing cortical choline acetyltransferase and high affinity choline uptake decrease after lesion of the nucleus basalis .
2713652	0	choline	92,99	nerve_growth_factor	20,39	choline	nerve growth factor	MESH:D002794	310738(Tax:10116)	Chemical	Gene	decrease|amod|START_ENTITY preventing|dobj|decrease monosialoganglioside|advcl|preventing monosialoganglioside|nsubj|Interaction Interaction|nmod|END_ENTITY	Interaction between nerve_growth_factor and GM1 monosialoganglioside in preventing cortical choline acetyltransferase and high affinity choline uptake decrease after lesion of the nucleus basalis .
8592155	0	choline	106,113	nerve_growth_factor	24,43	choline	nerve growth factor	MESH:D002794	310738(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY effects|nmod|transport effects|nmod|END_ENTITY	Differential effects of nerve_growth_factor on expression of choline_acetyltransferase and sodium-coupled choline transport in basal forebrain cholinergic neurons in culture .
11553644	0	choline	12,19	organic_cation_transporter_2	42,70	choline	organic cation transporter 2	MESH:D002794	29503(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY transport|dep|role role|nmod|END_ENTITY	Ventricular choline transport : a role for organic_cation_transporter_2 expressed in choroid_plexus .
9302091	0	choline	23,30	prolactin	48,57	choline	prolactin	MESH:D002794	24683(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|compound|END_ENTITY	Centrally administered choline increases plasma prolactin levels in conscious rats .
18518880	0	choline	8,15	renin	34,39	choline	renin	MESH:D002794	24715(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|response response|compound|END_ENTITY	Central choline suppresses plasma renin response to graded haemorrhage in rats .
9381808	0	choline	38,45	snail	61,66	choline	snail	MESH:D002794	6615	Chemical	Gene	sensitivity|amod|START_ENTITY sensitivity|nmod|END_ENTITY	-LSB- Generalized and local changes in the choline sensitivity of snail -LRB- Helix lucorum taurica Kryn -RRB- neurons after the single or tetanic local applications of acetylcholine -RSB- .
9291994	0	chondroitin	51,62	leukocyte_elastase	20,38	chondroitin	leukocyte elastase	MESH:D002807	1991	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Inhibition of human leukocyte_elastase activity by chondroitin sulfates .
22633136	0	chondroitin_sulfate	10,29	CYP1A2	71,77	chondroitin sulfate	CYP1A2	MESH:D002809	100328937(Tax:9986)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of chondroitin_sulfate on turpentine-induced down-regulation of CYP1A2 and CYP3A6 .
8381406	0	chondroitin_sulfate	4,23	thrombomodulin	34,48	chondroitin sulfate	thrombomodulin	MESH:D002809	7056	Chemical	Gene	moiety|amod|START_ENTITY moiety|nmod|END_ENTITY	The chondroitin_sulfate moiety of thrombomodulin binds a second molecule of thrombin .
16797005	0	chroman_carboxamide	21,40	interleukin-6	44,57	chroman carboxamide	interleukin-6	null	3569	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Inhibitory effect of chroman_carboxamide on interleukin-6 expression in response to lipopolysaccharide by preventing nuclear factor-kappaB activation in macrophages .
11139424	0	chromanols	66,76	MinK	20,24	chromanols	MinK	null	50488	Chemical	Gene	impact|nmod|START_ENTITY impact|nmod|END_ENTITY	Molecular impact of MinK on the enantiospecific block of I -LRB- Ks -RRB- by chromanols .
9630446	0	chromates	41,50	CD4	54,57	chromates	CD4	MESH:D002840	920	Chemical	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Effects of smoking , aromatic_amines , and chromates on CD4 + and CD8 + T lymphocytes in male workers .
22814419	0	chromenone	93,103	DNA-dependent_protein_kinase	38,66	chromenone	DNA-dependent protein kinase	CHEBI:38445	5591	Chemical	Gene	derivatives|compound|START_ENTITY inhibition|nmod|derivatives inhibition|nmod|END_ENTITY	Potent enantioselective inhibition of DNA-dependent_protein_kinase -LRB- DNA-PK -RRB- by atropisomeric chromenone derivatives .
23202848	0	chromenone	24,34	interleukin-5	50,63	chromenone	interleukin-5	CHEBI:38445	3567	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Identification of novel chromenone derivatives as interleukin-5 inhibitors .
23523388	0	chromenone	30,40	interleukin-5	56,69	chromenone	interleukin-5	CHEBI:38445	3567	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Design and synthesis of novel chromenone derivatives as interleukin-5 inhibitors .
26011700	0	chromium	72,80	B_cell_maturation_antigen	23,48	chromium	B cell maturation antigen	MESH:D002857	608	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nmod|effect	The regulatory role of B_cell_maturation_antigen on the toxic effect of chromium ions on human SaOS-2 osteoblasts .
26011700	0	chromium	72,80	B_cell_maturation_antigen	23,48	chromium	B cell maturation antigen	MESH:D002857	608	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nmod|effect	The regulatory role of B_cell_maturation_antigen on the toxic effect of chromium ions on human SaOS-2 osteoblasts .
17888472	0	chromium	24,32	IFN-gamma	54,63	chromium	IFN-gamma	MESH:D002857	396054(Tax:9031)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of supplemental chromium on interferon-gamma -LRB- IFN-gamma -RRB- mRNA expression in response to Newcastle_disease vaccine in broiler chicken .
12679171	0	chromium	10,18	apolipoprotein_A-I	22,40	chromium	apolipoprotein A-I	MESH:D002857	335	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of chromium on apolipoprotein_A-I expression in HepG2 cells .
10801929	0	chromium	5,13	insulin	107,114	chromium	insulin	MESH:D002857	397415(Tax:9823)	Chemical	Gene	supplementation|compound|START_ENTITY improves|nsubj|supplementation improves|advcl|decreasing decreasing|dobj|extraction extraction|nmod|END_ENTITY	High chromium yeast supplementation improves glucose tolerance in pigs by decreasing hepatic extraction of insulin .
15208835	0	chromium	33,41	insulin	45,52	chromium	insulin	MESH:D002857	3630	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	A scientific review : the role of chromium in insulin resistance .
16761396	0	chromium	10,18	insulin	26,33	chromium	insulin	MESH:D002857	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|resistance resistance|compound|END_ENTITY	Effect of chromium on the insulin resistance in patients with type_II_diabetes_mellitus .
18307976	0	chromium	19,27	insulin	28,35	chromium	insulin	MESH:D002857	3630	Chemical	Gene	interactions|compound|START_ENTITY interactions|compound|END_ENTITY	Molecular basis of chromium insulin interactions .
21216583	0	chromium	22,30	insulin	50,57	chromium	insulin	MESH:D002857	3630	Chemical	Gene	supplementation|compound|START_ENTITY supplementation|nmod|sensitivity sensitivity|compound|END_ENTITY	Effects of short-term chromium supplementation on insulin sensitivity and body composition in overweight children : randomized , double-blind , placebo-controlled study .
22128214	0	chromium	79,87	insulin	10,17	chromium	insulin	MESH:D002857	3630	Chemical	Gene	excretion|nmod|START_ENTITY associated|nmod|excretion associated|nsubjpass|resistance resistance|compound|END_ENTITY	Increased insulin resistance is associated with increased urinary excretion of chromium in non-diabetic , normotensive Saudi adults .
22423897	0	chromium	24,32	insulin	48,55	chromium	insulin	MESH:D002857	3630	Chemical	Gene	mechanisms|nmod|START_ENTITY Molecular|dobj|mechanisms Molecular|advcl|alleviating alleviating|dobj|resistance resistance|compound|END_ENTITY	Molecular mechanisms of chromium in alleviating insulin resistance .
23125907	0	chromium	53,61	insulin	7,14	chromium	insulin	MESH:D002857	3630	Chemical	Gene	treatment|nmod|START_ENTITY treatment|compound|END_ENTITY	Severe insulin resistance treatment with intravenous chromium in septic_shock patient .
6526265	0	chromium	101,109	insulin	70,77	chromium	insulin	MESH:D002857	3630	Chemical	Gene	supplementation|compound|START_ENTITY effect|nmod|supplementation Use|dep|effect Use|nmod|cell cell|nmod|assessment assessment|nmod|sensitivity sensitivity|compound|END_ENTITY	Use of the artificial beta cell -LRB- ABC -RRB- in the assessment of peripheral insulin sensitivity : effect of chromium supplementation in diabetic patients .
8529496	0	chromium	11,19	insulin	47,54	chromium	insulin	MESH:D002857	3630	Chemical	Gene	Effects|nmod|START_ENTITY supplementation|nsubj|Effects supplementation|advcl|fasting fasting|dobj|levels levels|compound|END_ENTITY	Effects of chromium supplementation on fasting insulin levels and lipid parameters in healthy , non-obese young subjects .
22521640	0	chromium	22,30	p53	101,104	chromium	p53	MESH:D002857	7157	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|pathway pathway|compound|END_ENTITY	WITHDRAWN : Hexavalent chromium induces premature senescence through reactive oxygen species-mediated p53 pathway in L-02 hepatocytes .
20514688	1	chromium_mitigate	40,57	insulin	92,99	chromium mitigate	insulin	null	3630	Chemical	Gene	resistance|compound|START_ENTITY resistance|compound|END_ENTITY	Antidiabetogenic effects of chromium_mitigate hyperinsulinemia-induced cellular insulin resistance via correction of plasma membrane cholesterol imbalance .
8569546	0	chromium_picolinate	55,74	insulin	20,27	chromium picolinate	insulin	MESH:C030614	3630	Chemical	Gene	role|nmod|START_ENTITY suggest|dobj|role suggest|nsubj|effects effects|nmod|END_ENTITY	Anabolic effects of insulin on bone suggest a role for chromium_picolinate in preservation of bone density .
20550951	0	chromogranins_A_and_B	96,117	Secretogranin_III	0,17	chromogranins A and B	Secretogranin III	null	29106	Chemical	Gene	study|nmod|START_ENTITY END_ENTITY|dep|study	Secretogranin_III in human neuroendocrine_tumours : a comparative immunohistochemical study with chromogranins_A_and_B and secretogranin_II .
7607625	0	chromogranins_A_and_B	82,103	Secretoneurin	0,13	chromogranins A and B	Secretoneurin	null	7857	Chemical	Gene	comparison|nmod|START_ENTITY END_ENTITY|dep|comparison	Secretoneurin in bronchopulmonary_carcinoids -- immunohistochemical comparison with chromogranins_A_and_B and secretogranin_II .
18426223	0	chromomycin_A3	102,116	topoisomerase_I	60,75	chromomycin A3	topoisomerase I	MESH:D014128	7150	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Studies of sequence-specific DNA binding , DNA cleavage , and topoisomerase_I inhibition by the dimeric chromomycin_A3 complexed with Fe -LRB- II -RRB- .
17064075	0	chromone-2-carboxamide	16,38	melanin_concentrating_hormone_receptor_1	39,79	chromone-2-carboxamide	melanin concentrating hormone receptor 1	null	83567(Tax:10116)	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|amod|END_ENTITY	Optimization of chromone-2-carboxamide melanin_concentrating_hormone_receptor_1 antagonists : assessment of potency , efficacy , and cardiovascular safety .
17350253	0	chromone-2-carboxamides	26,49	MCHr1	53,58	chromone-2-carboxamides	MCHr1	null	2847	Chemical	Gene	START_ENTITY|nmod|antagonists antagonists|amod|END_ENTITY	Identification of diamino chromone-2-carboxamides as MCHr1 antagonists with minimal hERG channel activity .
16762549	0	chromones	12,21	melanin-concentrating_hormone_receptor_1	47,87	chromones	melanin-concentrating hormone receptor 1	MESH:D002867	83567(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|antagonists antagonists|amod|END_ENTITY	Substituted chromones and quinolones as potent melanin-concentrating_hormone_receptor_1 antagonists .
26757549	0	chrysin	11,18	NOX4	36,40	chrysin	NOX4	MESH:C043561	85431(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of chrysin on expression of NOX4 and NF-kB in right ventricle of monocrotaline-induced pulmonary_arterial_hypertension of rats -RSB- .
26291395	0	chrysin	20,27	SULT1A3	81,88	chrysin	SULT1A3	MESH:C043561	6818	Chemical	Gene	transport|nmod|START_ENTITY transport|nmod|END_ENTITY	Efflux transport of chrysin and apigenin_sulfates in HEK293 cells overexpressing SULT1A3 : The role of multidrug resistance-associated protein 4 -LRB- MRP4/ABCC4 -RRB- .
16135700	0	chrysin	33,40	UGT1A1	13,19	chrysin	UGT1A1	MESH:C043561	54658	Chemical	Gene	induction|nmod|START_ENTITY induction|nsubj|END_ENTITY	Differential UGT1A1 induction by chrysin in primary human hepatocytes and HepG2 Cells .
17256720	0	chrysin	12,19	UGT1A1	66,72	chrysin	UGT1A1	MESH:C043561	54658	Chemical	Gene	role|nmod|START_ENTITY role|nmod|gene gene|compound|END_ENTITY	The role of chrysin and the ah_receptor in induction of the human UGT1A1 gene in vitro and in transgenic UGT1 mice .
20832301	0	chrysin	32,39	cytochrome_P450_1A2	54,73	chrysin	cytochrome P450 1A2	MESH:C043561	1544	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Isoform-selective inhibition of chrysin towards human cytochrome_P450_1A2 .
26724370	0	chrysophanol	25,37	P2X7	0,4	chrysophanol	P2X7	MESH:C027113	18439(Tax:10090)	Chemical	Gene	target|nmod|START_ENTITY END_ENTITY|nmod|target	P2X7 as a new target for chrysophanol to treat lipopolysaccharide-induced depression in mice .
1482690	0	chylomicron	18,29	Insulin	0,7	chylomicron	Insulin	null	3630	Chemical	Gene	production|compound|START_ENTITY decreases|dobj|production decreases|nsubj|END_ENTITY	Insulin decreases chylomicron production in human fetal small intestine .
26011164	0	chymostatin	11,22	chymase	26,33	chymostatin	chymase	MESH:C002101	29265(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effects of chymostatin , a chymase inhibitor , on blood pressure , plasma and tissue angiotensin __ II , renal haemodynamics and renal_excretion in two models of hypertension in the rat .
16667591	0	chymostatin	53,64	nitrate_reductase	17,34	chymostatin	nitrate reductase	MESH:C002101	542266(Tax:4577)	Chemical	Gene	Stabilization|nmod|START_ENTITY Stabilization|nmod|END_ENTITY	Stabilization of nitrate_reductase in maize roots by chymostatin .
23660068	0	ciclopirox	34,44	mTOR	6,10	ciclopirox	mTOR	MESH:C011585	21977(Tax:10090)	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Novel mTOR inhibitory activity of ciclopirox enhances parthenolide antileukemia activity .
16126800	0	ciclosporin	101,112	CD25	82,86	ciclosporin	CD25	MESH:D016572	3559	Chemical	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	An open label , single dose study to evaluate the safety , efficacy , and effects on CD25 expression of ciclosporin in patients with active rheumatoid_arthritis despite treatment with methotrexate and infliximab .
15099443	0	ciclosporin	82,93	CYP3A	106,111	ciclosporin	CYP3A	MESH:D016572	170509(Tax:10116)	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Influence of intravenous methylprednisolone pulse treatment on the disposition of ciclosporin and hepatic CYP3A activity in rats .
3055993	0	ciclosporin	11,22	renin	33,38	ciclosporin	renin	MESH:D016572	5972	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Effects of ciclosporin on plasma renin activity , catecholamines and prostaglandins in patients with idiopathic uveitis .
25116714	0	ciglitazone	13,24	ICAM-1	47,53	ciglitazone	ICAM-1	MESH:C039671	3383	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	PPARy ligand ciglitazone inhibits TNFa-induced ICAM-1 in human airway_smooth_muscle cells .
12697971	0	ciglitazone	27,38	PPAR-gamma	83,93	ciglitazone	PPAR-gamma	MESH:C039671	5468	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|role role|nmod|END_ENTITY	Negative growth effects of ciglitazone on kidney interstitial fibroblasts : role of PPAR-gamma .
17222225	0	ciglitazone	20,31	PPAR-gamma	0,10	ciglitazone	PPAR-gamma	MESH:C039671	5468	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	PPAR-gamma agonist , ciglitazone , increases pigmentation and migration of human melanocytes .
17597617	0	ciglitazone	47,58	PPARgamma	28,37	ciglitazone	PPARgamma	MESH:C039671	5468	Chemical	Gene	induces|advmod|START_ENTITY induces|nsubj|activation activation|nmod|agonist agonist|compound|END_ENTITY	Pro-MMP-2 activation by the PPARgamma agonist , ciglitazone , induces cell invasion through the generation of ROS and the activation of ERK .
21029675	0	ciglitazone	25,36	PPARy	65,70	ciglitazone	PPARy	MESH:C039671	5468	Chemical	Gene	START_ENTITY|nmod|cells cells|nmod|END_ENTITY	-LSB- Pro-apoptotic effect of ciglitazone in leukemic HL-60 cells via PPARy and P38 MAPK signaling pathway -RSB- .
22177955	0	ciglitazone	25,36	PPARy	119,124	ciglitazone	PPARy	MESH:C039671	5468	Chemical	Gene	induced|nmod|START_ENTITY induced|nmod|END_ENTITY	Cell death is induced by ciglitazone , a peroxisome_proliferator-activated_receptor_y -LRB- PPARy -RRB- agonist , independently of PPARy in human glioma cells .
17621259	0	ciglitazone	90,101	Peroxisome_proliferator-activated_receptor_gamma	0,48	ciglitazone	Peroxisome proliferator-activated receptor gamma	MESH:C039671	5468	Chemical	Gene	prostaglandin_J2|amod|START_ENTITY effect|nmod|prostaglandin_J2 required|nmod|effect required|nsubjpass|END_ENTITY	Peroxisome_proliferator-activated_receptor_gamma is required for the inhibitory effect of ciglitazone but not 15-deoxy-Delta_12 ,14 - prostaglandin_J2 on the NFkappaB pathway in human endothelial cells .
12774315	0	ciglitazone	68,79	peroxisome_proliferator-activated_receptor_gamma	11,59	ciglitazone	peroxisome proliferator-activated receptor gamma	MESH:C039671	25664(Tax:10116)	Chemical	Gene	ligands|amod|START_ENTITY ligands|amod|END_ENTITY	Effects of peroxisome_proliferator-activated_receptor_gamma ligands ciglitazone and 15-deoxy-delta_12 ,14 - prostaglandin_J2 on rat cultured cerebellar granule neuronal viability .
18335975	0	ciglitazone	93,104	peroxisome_proliferator-activated_receptor_gamma	36,84	ciglitazone	peroxisome proliferator-activated receptor gamma	MESH:C039671	5468	Chemical	Gene	START_ENTITY|nsubj|exploitation exploitation|nmod|agonist agonist|amod|END_ENTITY	Pharmacological exploitation of the peroxisome_proliferator-activated_receptor_gamma agonist ciglitazone to develop a novel class of androgen_receptor-ablative agents .
24925061	0	ciglitazone	72,83	phosphoinositide-dependent_protein_kinase_1	14,57	ciglitazone	phosphoinositide-dependent protein kinase 1	MESH:C039671	5163	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Repression of phosphoinositide-dependent_protein_kinase_1 expression by ciglitazone via Egr-1 represents a new approach for inhibition_of_lung_cancer cell growth .
7492120	0	cilastatin	63,73	dehydropeptidase_I	32,50	cilastatin	dehydropeptidase I	MESH:D015377	1800	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|appos|END_ENTITY	The renal membrane dipeptidase -LRB- dehydropeptidase_I -RRB- inhibitor , cilastatin , inhibits the bacterial metallo-beta-lactamase enzyme CphA .
3480361	0	cilastatin_sodium	12,29	dehydropeptidase-I	47,65	cilastatin sodium	dehydropeptidase-I	MESH:D015377	1800	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|inhibitor inhibitor|nmod|END_ENTITY	-LSB- Effects of cilastatin_sodium , an inhibitor of dehydropeptidase-I , on human urinary peptide excretion .
10607186	0	cilazapril	100,110	ACE	85,88	cilazapril	ACE	MESH:D017315	1636	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Arterial hypertension and sleep apnoea : effect of the angiotensin-converting enzyme -LRB- ACE -RRB- inhibitor cilazapril on continuously measured blood pressure during sleep and wakefulness .
11217909	0	cilazapril	66,76	ACE	4,7	cilazapril	ACE	MESH:D017315	1636	Chemical	Gene	usage|amod|START_ENTITY polymorphism|nmod|usage polymorphism|compound|END_ENTITY	The ACE gene polymorphism and cough threshold for capsaicin after cilazapril usage .
1689417	0	cilazapril	20,30	ACE	0,3	cilazapril	ACE	MESH:D017315	1636	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	ACE inhibition with cilazapril improves myocardial perfusion to the ischemic regions during exercise : a pilot study .
2548551	0	cilazapril	90,100	ACE	18,21	cilazapril	ACE	MESH:D017315	1636	Chemical	Gene	comparison|nmod|START_ENTITY assessment|dep|comparison assessment|nmod|activity activity|compound|END_ENTITY	The assessment of ACE activity in man following angiotensin_I challenges : a comparison of cilazapril , captopril and enalapril .
2548552	0	cilazapril	31,41	ACE	11,14	cilazapril	ACE	MESH:D017315	1636	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|Effects Effects|nmod|END_ENTITY	Effects of ACE inhibition with cilazapril on splanchnic and systemic haemodynamics in man .
8110053	0	cilazapril	67,77	ACE	52,55	cilazapril	ACE	MESH:D017315	1636	Chemical	Gene	-RSB-|amod|START_ENTITY monitoring|dep|-RSB- monitoring|nmod|pressure pressure|nmod|inhibitor inhibitor|compound|END_ENTITY	-LSB- Ambulatory monitoring of blood pressure with a new ACE inhibitor -- cilazapril -RSB- .
3034469	0	cilazapril	40,50	angiotensin-I	14,27	cilazapril	angiotensin-I	MESH:D017315	183	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|response response|compound|END_ENTITY	Inhibition of angiotensin-I response by cilazapril and its time course in normal volunteers .
7614501	0	cilazapril	68,78	angiotensin-I-converting_enzyme	83,114	cilazapril	angiotensin-I-converting enzyme	MESH:D017315	1636	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Remodeling of resistance arteries in human hypertension : effects of cilazapril , an angiotensin-I-converting_enzyme inhibitor .
2139303	0	cilazapril	44,54	angiotensin-converting_enzyme	62,91	cilazapril	angiotensin-converting enzyme	MESH:D017315	1636	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	The cardiovascular and endocrine effects of cilazapril , a new angiotensin-converting_enzyme inhibitor , in man .
8091000	0	cilazapril	15,25	angiotensin-converting_enzyme	27,56	cilazapril	angiotensin-converting enzyme	MESH:D017315	24310(Tax:10116)	Chemical	Gene	Treatment|nmod|START_ENTITY Treatment|appos|inhibitor inhibitor|amod|END_ENTITY	Treatment with cilazapril , angiotensin-converting_enzyme inhibitor , changes the affinity of arginine_vasopressin receptor in the kidney of the spontaneously hypertensive rat .
2436002	0	cilazapril	126,136	angiotensin_I	25,38	cilazapril	angiotensin I	MESH:D017315	183	Chemical	Gene	START_ENTITY|nsubj|responses responses|nmod|END_ENTITY	Hemodynamic responses to angiotensin_I in normal volunteers and the antagonism by the angiotensin-converting_enzyme inhibitor cilazapril .
8723394	0	cilazapril	81,91	angiotensin_I-converting_enzyme	96,127	cilazapril	angiotensin I-converting enzyme	MESH:D017315	1636	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Correction of remodeling and function of small arteries in human hypertension by cilazapril , an angiotensin_I-converting_enzyme inhibitor .
1708054	0	cilazapril	11,21	angiotensin_converting_enzyme	31,60	cilazapril	angiotensin converting enzyme	MESH:D017315	24310(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Effects of cilazapril , a novel angiotensin_converting_enzyme inhibitor , on the structure of pulmonary arteries of rats exposed to chronic hypoxia .
1833327	0	cilazapril	57,67	angiotensin_converting_enzyme	11,40	cilazapril	angiotensin converting enzyme	MESH:D017315	101020307	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|Effects Effects|nmod|END_ENTITY	Effects of angiotensin_converting_enzyme inhibition with cilazapril on intimal hyperplasia in injured arteries and vascular grafts in the baboon .
2527528	0	cilazapril	59,69	angiotensin_converting_enzyme	77,106	cilazapril	angiotensin converting enzyme	MESH:D017315	24310(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	A review of the preclinical cardiovascular pharmacology of cilazapril , a new angiotensin_converting_enzyme inhibitor .
3019375	0	cilazapril	101,111	angiotensin_converting_enzyme	60,89	cilazapril	angiotensin converting enzyme	MESH:D017315	1636	Chemical	Gene	relationships|amod|START_ENTITY relationships|nmod|END_ENTITY	The pharmacodynamics and dose-response relationships of the angiotensin_converting_enzyme inhibitor , cilazapril , in essential hypertension .
9640960	0	cilazapril	40,50	basic_fibroblast_growth_factor	76,106	cilazapril	basic fibroblast growth factor	MESH:D017315	54250(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Angiotensin-converting enzyme inhibitor cilazapril suppresses expression of basic_fibroblast_growth_factor messenger ribonucleic acid and protein in endothelial and intimal smooth muscle cells in a vascular_injury model of spontaneous hypertensive rats .
11797459	0	cilazapril	11,21	insulin	25,32	cilazapril	insulin	MESH:D017315	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|sensitivity sensitivity|compound|END_ENTITY	-LSB- Effect of cilazapril on insulin sensitivity in patients with essential arterial hypertension -RSB- .
14619584	0	cilazapril	12,22	vascular_endothelial_growth_factor	44,78	cilazapril	vascular endothelial growth factor	MESH:D017315	83785(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of cilazapril on the expression of vascular_endothelial_growth_factor and intercellular_adhesion_molecule-1 in diabetic rat glomeruli -RSB- .
17693653	0	cilengitide	128,139	alpha_nu_beta3_and_alpha_nu_beta5_integrin_receptor	64,115	cilengitide	alpha nu beta3 and alpha nu beta5 integrin receptor	MESH:C422910	1934	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Assessment of the biological and pharmacological effects of the alpha_nu_beta3_and_alpha_nu_beta5_integrin_receptor antagonist , cilengitide -LRB- EMD_121974 -RRB- , in patients with advanced solid tumors .
19801830	0	cilnidipine	47,58	voltage-dependent_calcium_channel	62,95	cilnidipine	voltage-dependent calcium channel	MESH:C065927	56827(Tax:10116)	Chemical	Gene	START_ENTITY|appos|blocker blocker|amod|END_ENTITY	Suppression of formalin-induced nociception by cilnidipine , a voltage-dependent_calcium_channel blocker .
19652884	0	cilostamide	37,48	Akt	101,104	cilostamide	Akt	MESH:C021294	24185(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Effects of the cAMP-elevating agents cilostamide , cilostazol and forskolin on the phosphorylation of Akt and GSK-3beta in platelets .
19282610	0	cilostazol	10,20	CD40_ligand	58,69	cilostazol	CD40 ligand	MESH:C045645	959	Chemical	Gene	treatment|amod|START_ENTITY Effect|nmod|treatment Effect|nmod|levels levels|compound|END_ENTITY	Effect of cilostazol treatment on adiponectin and soluble CD40_ligand levels in diabetic patients with peripheral arterial_occlusion_disease .
19516253	0	cilostazol	80,90	CYP3A	13,18	cilostazol	CYP3A	MESH:C045645	1576	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY polymorphisms|nmod|pharmacokinetics polymorphisms|nsubj|Influence Influence|nmod|END_ENTITY	Influence of CYP3A and CYP2C19 genetic polymorphisms on the pharmacokinetics of cilostazol in healthy subjects .
14603510	0	cilostazol	70,80	P-glycoprotein	21,35	cilostazol	P-glycoprotein	MESH:C045645	5243	Chemical	Gene	influence|nmod|START_ENTITY influence|nmod|END_ENTITY	Limited influence of P-glycoprotein on small-intestinal absorption of cilostazol , a high absorptive permeability drug .
18652777	0	cilostazol	11,21	TSP-1	43,48	cilostazol	TSP-1	MESH:C045645	445442(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Effects of cilostazol on thrombospondin-1 -LRB- TSP-1 -RRB- expression changes in the myocardium of diabetic rats .
19282610	0	cilostazol	10,20	adiponectin	34,45	cilostazol	adiponectin	MESH:C045645	9370	Chemical	Gene	treatment|amod|START_ENTITY Effect|nmod|treatment Effect|nmod|levels levels|compound|END_ENTITY	Effect of cilostazol treatment on adiponectin and soluble CD40_ligand levels in diabetic patients with peripheral arterial_occlusion_disease .
21256160	0	cilostazol	44,54	heme_oxygenase-1	13,29	cilostazol	heme oxygenase-1	MESH:C045645	15368(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Induction of heme_oxygenase-1 expression by cilostazol contributes to its anti-inflammatory effects in J774 murine macrophages .
9299535	0	cilostazol	14,24	heparin-binding_EGF-like_growth_factor	82,120	cilostazol	heparin-binding EGF-like growth factor	MESH:C045645	1839	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|amod|END_ENTITY	The effect of cilostazol , a cyclic nucleotide phosphodiesterase III inhibitor , on heparin-binding_EGF-like_growth_factor expression in macrophages and vascular smooth muscle cells .
11583728	0	cilostazol	34,44	interleukin-6	127,140	cilostazol	interleukin-6	MESH:C045645	3569	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|role role|nmod|END_ENTITY	Differential lipogenic effects of cilostazol and pentoxifylline in patients with intermittent_claudication : potential role for interleukin-6 .
23333827	0	cilostazol	14,24	matrix_metalloproteinase-1	46,72	cilostazol	matrix metalloproteinase-1	MESH:C045645	4312	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|nmod|END_ENTITY	The effect of cilostazol on the expression of matrix_metalloproteinase-1 and type_I_procollagen in ultraviolet-irradiated human dermal fibroblasts .
25780331	0	cilostazol	10,20	p50	28,31	cilostazol	p50	MESH:C045645	4790	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of cilostazol on the p50 of the oxygen-hemoglobin dissociation curve .
18652777	0	cilostazol	11,21	thrombospondin-1	25,41	cilostazol	thrombospondin-1	MESH:C045645	445442(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Effects of cilostazol on thrombospondin-1 -LRB- TSP-1 -RRB- expression changes in the myocardium of diabetic rats .
18959004	0	cilostazol	14,24	thrombospondin-1	42,58	cilostazol	thrombospondin-1	MESH:C045645	445442(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of cilostazol on expression of thrombospondin-1 in diabetic_retinopathy .
11524048	0	cilostazol	24,34	vascular_endothelial_growth_factor	57,91	cilostazol	vascular endothelial growth factor	MESH:C045645	7422	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Differential effects of cilostazol and pentoxifylline on vascular_endothelial_growth_factor in patients with intermittent_claudication .
6219029	0	cimetidine	10,20	ATPase	44,50	cimetidine	ATPase	MESH:D002927	1769	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of cimetidine on histamine-activated ATPase in human gastric_mucosa .
9454789	0	cimetidine	8,18	CYP2C6	36,42	cimetidine	CYP2C6	MESH:D002927	293989(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	In vivo cimetidine inhibits hepatic CYP2C6 and CYP2C11 but not CYP1A1 in adult male rats .
16315875	0	cimetidine	40,50	E-selectin	26,36	cimetidine	E-selectin	MESH:D002927	6401	Chemical	Gene	administration|amod|START_ENTITY END_ENTITY|nmod|administration	-LSB- An interesting change of E-selectin in cimetidine administration during anticancer drug use -RSB- .
18219847	0	cimetidine	11,21	E-selectin	25,35	cimetidine	E-selectin	MESH:D002927	6401	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effect of cimetidine on E-selectin expression on the vascular endothelium stimulated by anti-cancer drug -RSB- .
1648649	0	cimetidine	47,57	Gastrin	1,8	cimetidine	Gastrin	MESH:D002927	2520	Chemical	Gene	intake|amod|START_ENTITY secretion|nmod|intake insulin|acl|secretion END_ENTITY|appos|insulin	-LSB- Gastrin , insulin and glucagon secretion after cimetidine and sodium_hydrocarbonate intake in patients with duodenal ulcer -RSB- .
111967	0	cimetidine	44,54	Prolactin	0,9	cimetidine	Prolactin	MESH:D002927	5617	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Prolactin response to TRH after intravenous cimetidine .
43786	0	cimetidine	33,43	Prolactin	0,9	cimetidine	Prolactin	MESH:D002927	5617	Chemical	Gene	release|nmod|START_ENTITY release|compound|END_ENTITY	Prolactin release by intravenous cimetidine in man : evidence for a suprapituitary locus on action .
7386109	0	cimetidine	57,67	Prolactin	0,9	cimetidine	Prolactin	MESH:D002927	5617	Chemical	Gene	administration|compound|START_ENTITY man|nmod|administration secretion|nmod|man secretion|nsubj|END_ENTITY	Prolactin secretion in man following acute and long-term cimetidine administration .
760738	0	cimetidine	23,33	Prolactin	0,9	cimetidine	Prolactin	MESH:D002927	5617	Chemical	Gene	responses|xcomp|START_ENTITY responses|nsubj|END_ENTITY	Prolactin responses to cimetidine .
2563190	0	cimetidine	20,30	Somatostatin	0,12	cimetidine	Somatostatin	MESH:D002927	6750	Chemical	Gene	START_ENTITY|nsubj|versus versus|compound|END_ENTITY	Somatostatin versus cimetidine in the treatment of actively bleeding duodenal ulcer : a prospective , randomized , controlled trial .
3501692	0	cimetidine	14,24	aid	31,34	cimetidine	aid	MESH:D002927	57379	Chemical	Gene	Evaluation|nmod|START_ENTITY Evaluation|nmod|END_ENTITY	Evaluation of cimetidine as an aid in the management of non-variceal massive upper_gastrointestinal_haemorrhage .
9146753	0	cimetidine	10,20	cholecystokinin	72,87	cimetidine	cholecystokinin	MESH:D002927	885	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of cimetidine on basal and postprandial plasma concentrations of cholecystokinin and gastrin in humans .
20973869	0	cimetidine	57,67	cyclooxygenase-2	69,85	cimetidine	cyclooxygenase-2	MESH:D002927	5743	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Phase-II trial of combination treatment of interferon-a , cimetidine , cyclooxygenase-2 inhibitor and renin-angiotensin-system inhibitor -LRB- I-CCA therapy -RRB- for advanced_renal_cell_carcinoma .
8096713	0	cimetidine	15,25	cytochrome_P450	31,46	cimetidine	cytochrome P450	MESH:D002927	25251(Tax:10116)	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of cimetidine with cytochrome_P450 and effect on mixed-function oxidase activities of liver microsomes .
2910758	0	cimetidine	11,21	gastric_alcohol_dehydrogenase	25,54	cimetidine	gastric alcohol dehydrogenase	MESH:D002927	131	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|amod|END_ENTITY	Effects of cimetidine on gastric_alcohol_dehydrogenase activity and blood ethanol levels .
12503773	0	cimetidine	42,52	gastrin	87,94	cimetidine	gastrin	MESH:D002927	2520	Chemical	Gene	ranitidine|compound|START_ENTITY Effects|appos|ranitidine Effects|nmod|level level|compound|END_ENTITY	Effects of three H2-receptor antagonists -LRB- cimetidine , famotidine , ranitidine -RRB- on serum gastrin level .
1299331	0	cimetidine	27,37	gastrin	62,69	cimetidine	gastrin	MESH:D002927	25320(Tax:10116)	Chemical	Gene	administration|amod|START_ENTITY administration|nmod|levels levels|compound|END_ENTITY	The influence of prolonged cimetidine administration on serum gastrin levels and gastric_acid secretion in rats .
14043	0	cimetidine	10,20	gastrin	112,119	cimetidine	gastrin	MESH:D002927	2520	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of cimetidine on lower esophageal sphincter pressure , intragastric pH and serum levels of immunoreactive gastrin in man .
14861	0	cimetidine	49,59	gastrin	6,13	cimetidine	gastrin	MESH:D002927	2520	Chemical	Gene	therapy|amod|START_ENTITY weeks|nmod|therapy Serum|nmod|weeks Serum|dobj|levels levels|compound|END_ENTITY	Serum gastrin levels before and after 6 weeks of cimetidine therapy in patients with duodenal ulcer .
2902658	0	cimetidine	10,20	gastrin	64,71	cimetidine	gastrin	MESH:D002927	100685087	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of cimetidine , ranitidine and omeprazole on postprandial gastrin and somatostatin release in conscious dogs .
294920	0	cimetidine	42,52	gastrin	6,13	cimetidine	gastrin	MESH:D002927	2520	Chemical	Gene	therapy|compound|START_ENTITY END_ENTITY|nmod|therapy	Serum gastrin after 12 months ' continuous cimetidine therapy for duodenal ulcer .
3464244	0	cimetidine	63,73	gastrin	7,14	cimetidine	gastrin	MESH:D002927	2520	Chemical	Gene	vagotomy|amod|START_ENTITY concentrations|nmod|vagotomy concentrations|compound|END_ENTITY	Antral gastrin concentrations in duodenal ulcer patients after cimetidine and highly selective vagotomy .
364910	0	cimetidine	61,71	gastrin	14,21	cimetidine	gastrin	MESH:D002927	2520	Chemical	Gene	fasting|nmod|START_ENTITY fasting|dobj|levels levels|compound|END_ENTITY	Serum fasting gastrin levels after short-term treatment with cimetidine in patients with duodenal ulcer .
456231	0	cimetidine	21,31	gastrin	41,48	cimetidine	gastrin	MESH:D002927	2520	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of long-term cimetidine on serum gastrin in duodenal ulcer .
6689097	0	cimetidine	83,93	gastrin	7,14	cimetidine	gastrin	MESH:D002927	2520	Chemical	Gene	-RSB-|compound|START_ENTITY ulcer|nmod|-RSB- treatment|nmod|ulcer END_ENTITY|nmod|treatment	-LSB- Serum gastrin levels before and after short-term treatment of duodenal ulcer with cimetidine and pirenzepin -RSB- .
6692731	0	cimetidine	94,104	gastrin	40,47	cimetidine	gastrin	MESH:D002927	25320(Tax:10116)	Chemical	Gene	treatment|nmod|START_ENTITY END_ENTITY|nmod|treatment	Gastric secretory conditions and plasma gastrin levels in rats after prolonged treatment with cimetidine .
6720654	0	cimetidine	121,131	gastrin	17,24	cimetidine	gastrin	MESH:D002927	2520	Chemical	Gene	START_ENTITY|nsubj|response response|compound|END_ENTITY	Secretin-induced gastrin response in the Zollinger-Ellison_syndrome and chronic_duodenal_ulcer patients before and after cimetidine treatment .
7220403	0	cimetidine	111,121	gastrin	52,59	cimetidine	gastrin	MESH:D002927	2520	Chemical	Gene	Effect|acl|START_ENTITY Effect|nmod|treatment treatment|nmod|function function|amod|cimetidine cimetidine|nmod|year year|nmod|cell cell|amod|END_ENTITY	Effect of treatment with cimetidine for one year on gastrin cell and parietal cell function and sensitivity to cimetidine in patients with duodenal or gastric_ulcers .
7220403	0	cimetidine	25,35	gastrin	52,59	cimetidine	gastrin	MESH:D002927	2520	Chemical	Gene	START_ENTITY|nmod|year year|nmod|cell cell|amod|END_ENTITY	Effect of treatment with cimetidine for one year on gastrin cell and parietal cell function and sensitivity to cimetidine in patients with duodenal or gastric_ulcers .
3138120	0	cimetidine	11,21	interleukin-2	25,38	cimetidine	interleukin-2	MESH:D002927	3558	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Effects of cimetidine on interleukin-2 production by peripheral blood lymphocytes in advanced ovarian_carcinoma .
3501452	0	cimetidine	12,22	interleukin-2	34,47	cimetidine	interleukin-2	MESH:D002927	3558	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|production production|compound|END_ENTITY	-LSB- Effects of cimetidine and PSK on interleukin-2 production by PBL in patients with advanced ovarian_carcinoma during the course of chemotherapy -RSB- .
340324	0	cimetidine	10,20	intrinsic_factor	24,40	cimetidine	intrinsic factor	MESH:D002927	2694	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of cimetidine on intrinsic_factor and pepsin secretion in man .
6424229	0	cimetidine	10,20	intrinsic_factor	24,40	cimetidine	intrinsic factor	MESH:D002927	2694	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Effect of cimetidine on intrinsic_factor secretion stimulated by different doses of pentagastrin in patients with impaired_renal_function .
6102626	0	cimetidine	10,20	parathyroid_hormone	36,55	cimetidine	parathyroid hormone	MESH:D002927	5741	Chemical	Gene	START_ENTITY|acl|circulating circulating|dobj|END_ENTITY	Effect of cimetidine on circulating parathyroid_hormone in primary_hyperparathyroidism .
21383876	0	cimetidine	13,23	prolactin	45,54	cimetidine	prolactin	MESH:D002927	24683(Tax:10116)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|levels levels|compound|END_ENTITY	Influence of cimetidine and bromocriptine on prolactin levels in rat fertility .
3081918	0	cimetidine	46,56	prolactin	154,163	cimetidine	prolactin	MESH:D002927	5617	Chemical	Gene	administration|nmod|START_ENTITY Effect|nmod|administration Effect|nmod|hormones hormones|compound|END_ENTITY	Effect of a short-term oral administration of cimetidine and ranitidine on the basal and thyrotropin-releasing_hormone-stimulated serum concentrations of prolactin , thyrotropin and thyroid hormones in healthy volunteers .
478440	0	cimetidine	10,20	prolactin	42,51	cimetidine	prolactin	MESH:D002927	5617	Chemical	Gene	alter|nsubj|START_ENTITY alter|dobj|END_ENTITY	Long-term cimetidine does not alter serum prolactin .
549431	0	cimetidine	46,56	prolactin	6,15	cimetidine	prolactin	MESH:D002927	5617	Chemical	Gene	administration|amod|START_ENTITY Serum|nmod|administration Serum|dobj|response response|compound|END_ENTITY	Serum prolactin response to acute and chronic cimetidine administration in man .
6108555	0	cimetidine	22,32	prolactin	51,60	cimetidine	prolactin	MESH:D002927	5617	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|compound|END_ENTITY	Comparative effect of cimetidine and ranitidine on prolactin secretion .
6121748	0	cimetidine	33,43	prolactin	85,94	cimetidine	prolactin	MESH:D002927	24683(Tax:10116)	Chemical	Gene	drugs|compound|START_ENTITY effect|nmod|drugs studies|nmod|effect studies|nmod|END_ENTITY	Further studies on the effect of cimetidine and other neurotropic drugs on rat serum prolactin .
6619615	0	cimetidine	47,57	prolactin	62,71	cimetidine	prolactin	MESH:D002927	5617	Chemical	Gene	Effect|amod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	-LSB- Effect of a histamine H2-receptor antagonist , cimetidine , on prolactin secretion in women -RSB- .
6770354	0	cimetidine	19,29	prolactin	68,77	cimetidine	prolactin	MESH:D002927	5617	Chemical	Gene	START_ENTITY|nmod|values values|nmod|END_ENTITY	The effect of oral cimetidine on the basal and stimulated values of prolactin , thyroid stimulating hormone , follicle stimulating hormone and luteinizing hormone .
7128538	0	cimetidine	10,20	prolactin	24,33	cimetidine	prolactin	MESH:D002927	5617	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of cimetidine on prolactin secretion in normal controls and hyperthyroid patients .
760734	0	cimetidine	11,21	prolactin	68,77	cimetidine	prolactin	MESH:D002927	5617	Chemical	Gene	Failure|nmod|START_ENTITY Failure|acl|antagonise antagonise|dobj|suppression suppression|nmod|END_ENTITY	Failure of cimetidine to antagonise dopamine-induced suppression of prolactin in vitro .
12429554	0	cimetidine	13,23	renal_organic_anion_transporter_1	46,79	cimetidine	renal organic anion transporter 1	MESH:D002927	9356	Chemical	Gene	Transport|nmod|START_ENTITY Transport|nmod|END_ENTITY	Transport of cimetidine by flounder and human renal_organic_anion_transporter_1 .
15481993	0	cimicoxib	91,100	COX-2	65,70	cimicoxib	COX-2	MESH:C493522	26198(Tax:10116)	Chemical	Gene	START_ENTITY|amod|selective selective|amod|END_ENTITY	New water-soluble sulfonylphosphoramidic_acid derivatives of the COX-2 selective inhibitor cimicoxib .
23685411	0	cimicoxib	32,41	COX-2	51,56	cimicoxib	COX-2	MESH:C493522	804479(Tax:9615)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Detection and quantification of cimicoxib , a novel COX-2 inhibitor , in canine plasma by HPLC with spectrofluorimetric detection : development and validation of a new methodology .
6538844	0	cimoxatone	54,64	MAO-A	37,42	cimoxatone	MAO-A	MESH:C026234	4128	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Effect of a reversible and selective MAO-A inhibitor -LRB- cimoxatone -RRB- on diurnal variation in plasma prolactin level in man .
24285106	0	cinacalcet_hydrochloride	10,34	multiple_endocrine_neoplasia_type_1	92,127	cinacalcet hydrochloride	multiple endocrine neoplasia type 1	MESH:C476217	4221	Chemical	Gene	Impact|nmod|START_ENTITY Impact|nmod|END_ENTITY	Impact of cinacalcet_hydrochloride in clinical management of primary_hyperparathyroidism in multiple_endocrine_neoplasia_type_1 .
7916144	0	cinchophen	121,131	Fos	23,26	cinchophen	Fos	MESH:C084834	314322(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|nmod|protein protein|compound|END_ENTITY	Neuronal expression of Fos protein in the paraventricular nucleus of the hypothalamus after i.p. injection of ulcergenic cinchophen .
8981440	0	cinchophen	12,22	c-Fos	31,36	cinchophen	c-Fos	MESH:C084834	314322(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Ulcerogenic cinchophen induces c-Fos expression in CRH-secreting cells in the PVH of rat brain .
23144445	0	cindunistat	107,118	iNOS	91,95	cindunistat	iNOS	MESH:C578791	4843	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	A 2-year randomised , double-blind , placebo-controlled , multicentre study of oral selective iNOS inhibitor , cindunistat -LRB- SD-6010 -RRB- , in patients with symptomatic osteoarthritis_of_the_knee .
20955755	0	cinnamaldehyde	11,25	GLUT1	63,68	cinnamaldehyde	GLUT1	MESH:C012843	20525(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of cinnamaldehyde on the glucose transport activity of GLUT1 .
15931068	0	cinnamaldehyde	49,63	TRPA1	0,5	cinnamaldehyde	TRPA1	MESH:C012843	8989	Chemical	Gene	effects|nmod|START_ENTITY activation|dep|effects activation|compound|END_ENTITY	TRPA1 and TRPM8 activation in humans : effects of cinnamaldehyde and menthol .
21466812	0	cinnamaldehyde	106,120	TRPA1	19,24	cinnamaldehyde	TRPA1	MESH:C012843	277328(Tax:10090)	Chemical	Gene	application|nmod|START_ENTITY evoked|nmod|application evoked|nsubj|involvement involvement|nmod|activation activation|compound|END_ENTITY	The involvement of TRPA1 channel activation in the inflammatory response evoked by topical application of cinnamaldehyde to mice .
23007061	0	cinnamaldehyde	13,27	TRPA1	31,36	cinnamaldehyde	TRPA1	MESH:C012843	277328(Tax:10090)	Chemical	Gene	Ingestion|nmod|START_ENTITY Ingestion|appos|agonist agonist|compound|END_ENTITY	Ingestion of cinnamaldehyde , a TRPA1 agonist , reduces visceral fats in mice fed a high-fat and high-sucrose diet .
23271453	0	cinnamaldehyde	19,33	TRPA1	55,60	cinnamaldehyde	TRPA1	MESH:C012843	277328(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Bimodal effects of cinnamaldehyde and camphor on mouse TRPA1 .
26108952	0	cinnamaldehyde	81,95	TRPA1	66,71	cinnamaldehyde	TRPA1	MESH:C012843	312896(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|facilitation facilitation|nmod|rhythm rhythm|nmod|treatment treatment|nmod|agonist agonist|compound|END_ENTITY	Long-lasting facilitation of respiratory rhythm by treatment with TRPA1 agonist , cinnamaldehyde .
20363216	0	cinnamaldehyde	25,39	phosphoenolpyruvate_carboxykinase	90,123	cinnamaldehyde	phosphoenolpyruvate carboxykinase	MESH:C012843	362282(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|regulation regulation|nmod|END_ENTITY	Insulinotropic effect of cinnamaldehyde on transcriptional regulation of pyruvate kinase , phosphoenolpyruvate_carboxykinase , and GLUT4 translocation in experimental diabetic rats .
19080170	0	cinnamaldehyde	25,39	retinol-binding_protein_4	75,100	cinnamaldehyde	retinol-binding protein 4	MESH:C012843	25703(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|amod|END_ENTITY	Anti-diabetic effects of cinnamaldehyde and berberine and their impacts on retinol-binding_protein_4 expression in rats with type_2_diabetes_mellitus .
22957721	0	cinnamic_acid	20,33	protein_tyrosine_phosphatase_1B	49,80	cinnamic acid	protein tyrosine phosphatase 1B	MESH:C029010	5770	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	In vitro effects of cinnamic_acid derivatives on protein_tyrosine_phosphatase_1B .
8323546	0	cinnarizine	49,60	CYP2D6	15,21	cinnarizine	CYP2D6	MESH:D002936	1565	Chemical	Gene	metabolism|nmod|START_ENTITY Involvement|nmod|metabolism Involvement|nmod|END_ENTITY	Involvement of CYP2D6 in oxidative metabolism of cinnarizine and flunarizine in human liver microsomes .
20073224	0	cinobufagin	11,22	bcl-2	45,50	cinobufagin	bcl-2	MESH:C002471	100009447(Tax:9986)	Chemical	Gene	START_ENTITY|nmod|expressions expressions|nmod|mRNA mRNA|amod|END_ENTITY	-LSB- Effect of cinobufagin on the expressions of bcl-2 mRNA and bax mRNA and the proliferation of lens epithelial cells -RSB- .
20118004	0	cinobufagin	11,22	nuclear_factor-kappaB	26,47	cinobufagin	nuclear factor-kappaB	MESH:C002471	4790	Chemical	Gene	START_ENTITY|nmod|pathway pathway|amod|END_ENTITY	-LSB- Effect of cinobufagin on nuclear_factor-kappaB pathway in HepG2 cells -RSB- .
12709818	0	cipamfylline	35,47	PDE-4	18,23	cipamfylline	PDE-4	MESH:C466758	5141	Chemical	Gene	effect|appos|START_ENTITY effect|nmod|inhibitor inhibitor|compound|END_ENTITY	The effect of the PDE-4 inhibitor -LRB- cipamfylline -RRB- in two human models of irritant_contact_dermatitis .
12025914	0	ciprofibrate	10,22	C-reactive_protein	26,44	ciprofibrate	C-reactive protein	MESH:C019304	1401	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|compound|END_ENTITY	Effect of ciprofibrate on C-reactive_protein and fibrinogen levels .
9641260	0	ciprofibrate	38,50	catalase	152,160	ciprofibrate	catalase	MESH:C019304	12359(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Effect of the peroxisome proliferator ciprofibrate on lipid peroxidation and 8-hydroxydeoxyguanosine formation in transgenic_mice with elevated hepatic catalase activity .
10509752	0	ciprofibrate	104,116	peroxisome_proliferator-activated_receptor_alpha	19,67	ciprofibrate	peroxisome proliferator-activated receptor alpha	MESH:C019304	25747(Tax:10116)	Chemical	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of peroxisome_proliferator-activated_receptor_alpha in rat Fao cells and stimulation by ciprofibrate .
16552356	0	ciprofloxacin	14,27	CD14	31,35	ciprofloxacin	CD14	MESH:D002939	929	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of ciprofloxacin on CD14 and toll-like_receptor-4 expression on human monocytes .
21115395	0	ciprofloxacin	13,26	IS256	80,85	ciprofloxacin	IS256	MESH:D002939	17363256	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of ciprofloxacin and vancomycin on mutation rate and transposition of IS256 in Staphylococcus_aureus .
8569232	0	ciprokiren	29,39	renin	49,54	ciprokiren	renin	MESH:C085570	403838(Tax:9615)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Acute hemodynamic effects of ciprokiren , a novel renin inhibitor , in sodium-depleted dogs .
11039189	0	ciproxifan	39,49	histamine_H3-receptor	53,74	ciproxifan	histamine H3-receptor	MESH:C115705	11255	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Convenient procedures for synthesis of ciproxifan , a histamine_H3-receptor antagonist .
11055360	0	ciproxifan	29,39	histamine_H3-receptor	81,102	ciproxifan	histamine H3-receptor	MESH:C115705	11255	Chemical	Gene	Analogues|nmod|START_ENTITY Analogues|appos|prototype prototype|acl|generating generating|dobj|antagonists antagonists|amod|END_ENTITY	Analogues and derivatives of ciproxifan , a novel prototype for generating potent histamine_H3-receptor antagonists .
9473144	0	cis-8-OH-PBZI	46,59	Fos	75,78	cis-8-OH-PBZI	Fos	MESH:C111033	314322(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	The preferential dopamine_D3_receptor agonist cis-8-OH-PBZI induces limbic Fos expression in rat brain .
9548380	0	cis-8-OH-PBZI	86,99	dopamine_D3_receptor	57,77	cis-8-OH-PBZI	dopamine D3 receptor	MESH:C111033	29238(Tax:10116)	Chemical	Gene	agonist|xcomp|START_ENTITY agonist|nsubj|effects effects|nmod|END_ENTITY	Behavioral and neurochemical effects of the preferential dopamine_D3_receptor agonist cis-8-OH-PBZI .
9526055	0	cis-and_trans-flupenthixol	151,177	NMDAR2B	86,93	cis-and trans-flupenthixol	NMDAR2B	null	24410(Tax:10116)	Chemical	Gene	treatment|nmod|START_ENTITY END_ENTITY|nmod|treatment	Gene expression studies of mRNAs encoding the NMDA receptor subunits NMDAR1 , NMDAR2A , NMDAR2B , NMDAR2C , and NMDAR2D following long-term treatment with cis-and_trans-flupenthixol as a model for understanding the mode of action of schizophrenia drug treatment .
4067362	0	cis-diamminedichloroplatinum	10,38	erythropoietin	42,56	cis-diamminedichloroplatinum	erythropoietin	MESH:D002945	2056	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|production production|compound|END_ENTITY	Effect of cis-diamminedichloroplatinum on erythropoietin production and hematopoietic progenitor cells .
9458352	0	cis-diamminedichloroplatinum	46,74	p53	8,11	cis-diamminedichloroplatinum	p53	MESH:D002945	7157	Chemical	Gene	activity|amod|START_ENTITY Role|nmod|activity Role|nmod|END_ENTITY	Role of p53 and apoptosis in sensitization of cis-diamminedichloroplatinum antitumor activity by interleukin-1 in ovarian_carcinoma cells .
1354671	0	cis-diamminedichloroplatinum	124,152	xeroderma_pigmentosum_group_A	78,107	cis-diamminedichloroplatinum	xeroderma pigmentosum group A	MESH:D002945	7507	Chemical	Gene	cells|nmod|START_ENTITY cells|compound|END_ENTITY	Restoration of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- complex formation in xeroderma_pigmentosum_group_A cells following cis-diamminedichloroplatinum -LRB- II -RRB- - treatment by cell fusion with normal cells .
3013099	0	cis-platinum	31,43	PAM	73,76	cis-platinum	PAM	MESH:D002945	5066	Chemical	Gene	Combination|nmod|START_ENTITY Combination|appos|END_ENTITY	-LSB- Combination chemotherapy with cis-platinum , adriamycin and mitomycin_C -LRB- PAM -RRB- in the treatment of non-small_cell_carcinoma_of_the_lung -RSB- .
15096205	0	cis-retinoids	46,59	alcohol_dehydrogenase	19,40	cis-retinoids	alcohol dehydrogenase	null	10327	Chemical	Gene	specificity|nmod|START_ENTITY specificity|nmod|END_ENTITY	The specificity of alcohol_dehydrogenase with cis-retinoids .
15071348	0	cis-tetrahydrodaidzein	26,48	ERK-1	58,63	cis-tetrahydrodaidzein	ERK-1	MESH:C433164	5595	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|compound|END_ENTITY	The isoflavone metabolite cis-tetrahydrodaidzein inhibits ERK-1 activation and proliferation in human vascular smooth muscle cells .
10319918	0	cis-unsaturated_fatty_acids	10,37	AK-5	122,126	cis-unsaturated fatty acids	AK-5	null	26289	Chemical	Gene	cells|amod|START_ENTITY cells|appos|END_ENTITY	Effect of cis-unsaturated_fatty_acids on the activity of protein kinases and protein phosphorylation in macrophage tumor -LRB- AK-5 -RRB- cells in vitro .
9111529	0	cis-unsaturated_fatty_acids	10,37	angiotensin-converting_enzyme	76,105	cis-unsaturated fatty acids	angiotensin-converting enzyme	null	1636	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	Effect of cis-unsaturated_fatty_acids , prostaglandins , and free radicals on angiotensin-converting_enzyme activity in vitro .
3501579	0	cis-urocanic_acid	99,116	interleukin-1	50,63	cis-urocanic acid	interleukin-1	CHEBI:30818	3552	Chemical	Gene	secretion|nmod|START_ENTITY secretion|amod|END_ENTITY	Stereospecific inhibition of human epidermal cell interleukin-1 secretion and HLA-DR expression by cis-urocanic_acid .
8617132	0	cisapride	10,19	CCK	55,58	cisapride	CCK	MESH:D020117	885	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of cisapride on gallbladder emptying and plasma CCK in normal and vagotomized human subjects .
10859153	0	cisapride	15,24	cytochrome_P450	40,55	cisapride	cytochrome P450	MESH:D020117	4051	Chemical	Gene	START_ENTITY|nmod|system system|amod|END_ENTITY	Interaction of cisapride with the human cytochrome_P450 system : metabolism and inhibition studies .
3544336	0	cisapride	11,20	pancreatic_polypeptide	41,63	cisapride	pancreatic polypeptide	MESH:D020117	5539	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|nmod|END_ENTITY	Effects of cisapride on the secretion of pancreatic_polypeptide in healthy volunteers .
23339090	0	cisplatin	34,43	14-3-3	8,14	cisplatin	14-3-3	MESH:D002945	10971	Chemical	Gene	Role|acl|START_ENTITY Role|nmod|END_ENTITY	Role of 14-3-3 in resistance to cisplatin in non-small cell lung_cancer cells .
11034077	0	cisplatin	138,147	AKT	34,37	cisplatin	AKT	MESH:D002945	207	Chemical	Gene	induced|nmod|START_ENTITY p21WAF1/CIP1/SDI1|acl|induced expression|nmod|p21WAF1/CIP1/SDI1 role|nmod|expression plays|dobj|role plays|nsubj|transduction transduction|compound|END_ENTITY	The phosphatidylinositol_3-kinase / AKT signal transduction pathway plays a critical role in the expression of p21WAF1/CIP1/SDI1 induced by cisplatin and paclitaxel .
15350374	0	cisplatin	19,28	AKT	0,3	cisplatin	AKT	MESH:D002945	207	Chemical	Gene	chemoresistance|compound|START_ENTITY involvement|nmod|chemoresistance involvement|compound|END_ENTITY	AKT involvement in cisplatin chemoresistance of human uterine cancer cells .
20959404	0	cisplatin	137,146	AKT	103,106	cisplatin	AKT	MESH:D002945	207	Chemical	Gene	confers|advcl|START_ENTITY confers|nsubj|END_ENTITY	cIAP2 upregulated by E6 oncoprotein via epidermal_growth_factor_receptor / phosphatidylinositol_3-kinase / AKT pathway confers resistance to cisplatin in human_papillomavirus_16 / 18-infected lung_cancer .
23095324	0	cisplatin	58,67	AKT	37,40	cisplatin	AKT	MESH:D002945	207	Chemical	Gene	reveals|xcomp|START_ENTITY reveals|dobj|role role|nmod|END_ENTITY	Molecular imaging reveals a role for AKT in resistance to cisplatin for ovarian_endometrioid_adenocarcinoma .
23426872	0	cisplatin	37,46	AKT	14,17	cisplatin	AKT	MESH:D002945	207	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of AKT gene expression by cisplatin .
23546174	0	cisplatin	80,89	AKT	18,21	cisplatin	AKT	MESH:D002945	207	Chemical	Gene	decreases|xcomp|START_ENTITY decreases|nsubj|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of AKT decreases the chemosensitivity of gastric_cancer cells to cisplatin in vitro and in vivo .
24165223	0	cisplatin	81,90	AKT	29,32	cisplatin	AKT	MESH:D002945	207	Chemical	Gene	contributes|xcomp|START_ENTITY contributes|nsubj|Up-regulation Up-regulation|nmod|survivin survivin|nmod|END_ENTITY	Up-regulation of survivin by AKT and hypoxia-inducible_factor __ 1a contributes to cisplatin resistance in gastric_cancer .
24751980	0	cisplatin	77,86	AKT	95,98	cisplatin	AKT	MESH:D002945	207	Chemical	Gene	START_ENTITY|nmod|pathways pathways|compound|END_ENTITY	Secreted clusterin gene silencing enhances chemosensitivity of a549 cells to cisplatin through AKT and ERK1/2 pathways in vitro .
21266360	0	cisplatin	48,57	AKT1	70,74	cisplatin	AKT1	MESH:D002945	207	Chemical	Gene	START_ENTITY|nmod|regulation regulation|compound|END_ENTITY	DeltaNp63alpha confers tumor cell resistance to cisplatin through the AKT1 transcriptional regulation .
18478230	0	cisplatin	101,110	ASNA1	0,5	cisplatin	ASNA1	MESH:D002945	439	Chemical	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	ASNA1 , an ATPase targeting tail-anchored proteins , regulates melanoma cell growth and sensitivity to cisplatin and arsenite .
25359574	0	cisplatin	20,29	ATF2	0,4	cisplatin	ATF2	MESH:D002945	1386	Chemical	Gene	contributes|xcomp|START_ENTITY contributes|nsubj|END_ENTITY	ATF2 contributes to cisplatin resistance in Non-Small_cell_lung_cancer and Celastrol induces cisplatin re-sensitization through inhibition of JNK/ATF2 pathway .
17978167	0	cisplatin	13,22	ATP7B	56,61	cisplatin	ATP7B	MESH:D002945	540	Chemical	Gene	Transport|nmod|START_ENTITY Transport|nmod|END_ENTITY	Transport of cisplatin by the copper efflux transporter ATP7B .
22966294	0	cisplatin	60,69	ATP7B	0,5	cisplatin	ATP7B	MESH:D002945	540	Chemical	Gene	associated|xcomp|START_ENTITY associated|nsubjpass|expression expression|compound|END_ENTITY	ATP7B expression is associated with in vitro sensitivity to cisplatin in non-small_cell_lung_cancer .
24058603	0	cisplatin	173,182	ATP7B	34,39	cisplatin	ATP7B	MESH:D002945	540	Chemical	Gene	received|nmod|START_ENTITY IIA|acl:relcl|received TOP|dobj|IIA TOP|nsubj|value value|nmod|TOPOI TOPOI|appos|END_ENTITY	Predictive value of BRCA1 , ERCC1 , ATP7B , PKM2 , TOPOI , TOP - IIA , TOPOIIB and C-MYC genes in patients with small_cell_lung_cancer -LRB- SCLC -RRB- who received first line therapy with cisplatin and etoposide .
18478230	0	cisplatin	101,110	ATPase	10,16	cisplatin	ATPase	MESH:D002945	1769	Chemical	Gene	regulates|nmod|START_ENTITY regulates|nsubj|ASNA1 ASNA1|appos|END_ENTITY	ASNA1 , an ATPase targeting tail-anchored proteins , regulates melanoma cell growth and sensitivity to cisplatin and arsenite .
6123388	0	cisplatin	34,43	ATPase	24,30	cisplatin	ATPase	MESH:D002945	1769	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	The inhibition of renal ATPase by cisplatin and some biotransformation products .
12894503	0	cisplatin	73,82	ATR	32,35	cisplatin	ATR	MESH:D002945	545	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activity activity|compound|END_ENTITY	Inhibition of cisplatin-induced ATR activity and enhanced sensitivity to cisplatin .
21258400	0	cisplatin	13,22	ATR	0,3	cisplatin	ATR	MESH:D002945	545	Chemical	Gene	resistance|compound|START_ENTITY mediates|dobj|resistance mediates|nsubj|END_ENTITY	ATR mediates cisplatin resistance in a p53 genotype-specific manner .
17918180	0	cisplatin	13,22	Akt	0,3	cisplatin	Akt	MESH:D002945	207	Chemical	Gene	resistance|compound|START_ENTITY promotes|dobj|resistance promotes|nsubj|END_ENTITY	Akt promotes cisplatin resistance in human ovarian_cancer cells through inhibition of p53 phosphorylation and nuclear function .
18071906	0	cisplatin	71,80	Akt	0,3	cisplatin	Akt	MESH:D002945	207	Chemical	Gene	regulate|nmod|START_ENTITY regulate|nsubj|END_ENTITY	Akt and XIAP regulate the sensitivity of human uterine cancer cells to cisplatin , doxorubicin and taxol .
20214883	4	cisplatin	659,668	Akt	634,637	cisplatin	Akt	MESH:D002945	207	Chemical	Gene	counterparts|amod|START_ENTITY END_ENTITY|acl|counterparts	Furthermore , we generated cisplatin-resistant cells and found that resistant cells express a higher level of activated Akt as compared to their cisplatin sensitive counterparts .
20599289	0	cisplatin	51,60	Akt	0,3	cisplatin	Akt	MESH:D002945	207	Chemical	Gene	resistance|compound|START_ENTITY mediating|dobj|resistance GRP78|advcl|mediating cells|amod|GRP78 target|nmod|cells target|nsubj|END_ENTITY	Akt is the downstream target of GRP78 in mediating cisplatin resistance in ER stress-tolerant human lung_cancer cells .
21539750	0	cisplatin	32,41	Akt	83,86	cisplatin	Akt	MESH:D002945	207	Chemical	Gene	resistance|compound|START_ENTITY promote|dobj|resistance promote|nmod|activation activation|compound|END_ENTITY	CCR9-CCL25 interactions promote cisplatin resistance in breast_cancer cell through Akt activation in a PI3K-dependent and FAK-independent fashion .
21570766	0	cisplatin	61,70	Akt	94,97	cisplatin	Akt	MESH:D002945	207	Chemical	Gene	cytotoxicity|nmod|START_ENTITY potentiates|dobj|cytotoxicity potentiates|nmod|inhibitions inhibitions|nmod|END_ENTITY	RasGAP-derived peptide 38GAP potentiates the cytotoxicity of cisplatin through inhibitions of Akt , ERK and NF-kB in colon_carcinoma HCT116 cells .
21686164	0	cisplatin	71,80	Akt	13,16	cisplatin	Akt	MESH:D002945	207	Chemical	Gene	treatment|compound|START_ENTITY induced|nmod|treatment apoptosis|acl|induced sensitizes|nmod|apoptosis sensitizes|nsubj|Knockdown Knockdown|nmod|END_ENTITY	Knockdown of Akt sensitizes osteosarcoma cells to apoptosis induced by cisplatin treatment .
23351152	0	cisplatin	18,27	Akt	116,119	cisplatin	Akt	MESH:D002945	207	Chemical	Gene	sensitivity|compound|START_ENTITY sensitivity|dep|requirement requirement|nmod|down-regulation down-regulation|compound|END_ENTITY	PRIMA-1 increases cisplatin sensitivity in chemoresistant ovarian_cancer cells with p53 mutation : a requirement for Akt down-regulation .
23408563	0	cisplatin	99,108	Akt	143,146	cisplatin	Akt	MESH:D002945	207	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Suppression of chloride_channel_3 expression facilitates sensitivity of human glioma U251 cells to cisplatin through concomitant inhibition of Akt and autophagy .
23970333	0	cisplatin	29,38	Akt	72,75	cisplatin	Akt	MESH:D002945	207	Chemical	Gene	resistance|compound|START_ENTITY overcome|dobj|resistance overcome|nmod|inhibition inhibition|nmod|END_ENTITY	p53 restoration can overcome cisplatin resistance through inhibition of Akt as well as induction of Bax .
25154814	0	cisplatin	12,21	Akt	0,3	cisplatin	Akt	MESH:D002945	207	Chemical	Gene	chemoresistance|compound|START_ENTITY confers|dobj|chemoresistance confers|nsubj|END_ENTITY	Akt confers cisplatin chemoresistance in human gynecological carcinoma cells by modulating PPM1D stability .
26998277	0	cisplatin	45,54	Akt	0,3	cisplatin	Akt	MESH:D002945	207	Chemical	Gene	effect|nmod|START_ENTITY enhances|dobj|effect enhances|nsubj|MK-2206 MK-2206|compound|END_ENTITY	Akt inhibitor MK-2206 enhances the effect of cisplatin in gastric_cancer cells .
22996741	0	cisplatin	57,66	Apaf-1	94,100	cisplatin	Apaf-1	MESH:D002945	317	Chemical	Gene	START_ENTITY|nmod|regulation regulation|nmod|expression expression|compound|END_ENTITY	MiR-155 inhibits the sensitivity of lung_cancer cells to cisplatin via negative regulation of Apaf-1 expression .
25082261	0	cisplatin	24,33	Aurora-A	0,8	cisplatin	Aurora-A	MESH:D002945	6790	Chemical	Gene	contributes|xcomp|START_ENTITY contributes|nsubj|END_ENTITY	Aurora-A contributes to cisplatin resistance and lymphatic metastasis in non-small cell lung_cancer and predicts poor prognosis .
21311599	0	cisplatin	63,72	BMI-1	18,23	cisplatin	BMI-1	MESH:D002945	648	Chemical	Gene	treatment|compound|START_ENTITY promotes|nmod|treatment promotes|nsubj|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of BMI-1 promotes cell growth and resistance to cisplatin treatment in osteosarcoma .
17410096	0	cisplatin	32,41	Bax	25,28	cisplatin	Bax	MESH:D002945	12028(Tax:10090)	Chemical	Gene	nephrotoxicity|compound|START_ENTITY role|nmod|nephrotoxicity role|nmod|END_ENTITY	The pathological role of Bax in cisplatin nephrotoxicity .
25057072	0	cisplatin	51,60	Bmi-1	21,26	cisplatin	Bmi-1	MESH:D002945	648	Chemical	Gene	resistance|compound|START_ENTITY reversing|dobj|resistance silencing|advcl|reversing silencing|dobj|expression expression|compound|END_ENTITY	-LSB- Effect of silencing Bmi-1 expression in reversing cisplatin resistance in lung_cancer cells and its mechanism -RSB- .
14969818	0	cisplatin	22,31	CAD	91,94	cisplatin	CAD	MESH:D002945	13368(Tax:10090)	Chemical	Gene	treatment|nmod|START_ENTITY treatment|appos|END_ENTITY	Combined treatment of cisplatin and overexpression of caspase-activated_deoxyribonuclease -LRB- CAD -RRB- promotes apoptosis in vitro and in vivo .
26349992	0	cisplatin	58,67	CD44	90,94	cisplatin	CD44	MESH:D002945	960	Chemical	Gene	START_ENTITY|nmod|cancer cancer|compound|END_ENTITY	Low-dose all-trans_retinoic_acid enhances cytotoxicity of cisplatin and 5-fluorouracil on CD44 -LRB- + -RRB- cancer stem cells .
19800108	0	cisplatin	37,46	CD70	17,21	cisplatin	CD70	MESH:D002945	970	Chemical	Gene	resistance|compound|START_ENTITY END_ENTITY|nmod|resistance	Immune modulator CD70 as a potential cisplatin resistance predictive marker in ovarian_cancer .
17305640	0	cisplatin	11,20	CD95	91,95	cisplatin	CD95	MESH:D002945	355	Chemical	Gene	Effects|acl|START_ENTITY retinoic_acid|nsubj|Effects retinoic_acid|nmod|expression expression|nmod|Fas Fas|appos|END_ENTITY	Effects of cisplatin , alpha-interferon , and 13-cis retinoic_acid on the expression of Fas -LRB- CD95 -RRB- , intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- , and epidermal_growth_factor_receptor -LRB- EGFR -RRB- in oral_cancer cell lines .
9359490	0	cisplatin	46,55	CD95	100,104	cisplatin	CD95	MESH:D002945	14102(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Treatment of the P815 murine mastocytoma with cisplatin or etoposide up-regulates cell-surface Fas -LRB- CD95 -RRB- expression and increases sensitivity to anti-Fas antibody-mediated cytotoxicity and to lysis by anti-CD3-activated killer-T cells .
11137204	0	cisplatin	67,76	CPT-11	39,45	cisplatin	CPT-11	MESH:D002945	963084(Tax:115711)	Chemical	Gene	combination|nmod|START_ENTITY study|nmod|combination study|appos|END_ENTITY	A dose-escalation study of irinotecan -LRB- CPT-11 -RRB- in combination with cisplatin in patients with advanced non-small_cell_lung_cancer previously treated with a docetaxel-based front line chemotherapy .
15013590	0	cisplatin	50,59	CPT-11	37,43	cisplatin	CPT-11	MESH:D002945	963084(Tax:115711)	Chemical	Gene	administration|nmod|START_ENTITY administration|appos|END_ENTITY	Weekly administration of irinotecan -LRB- CPT-11 -RRB- plus cisplatin for refractory or relapsed small_cell_lung_cancer .
17214329	0	cisplatin	50,59	CPT-11	37,43	cisplatin	CPT-11	MESH:D002945	963084(Tax:115711)	Chemical	Gene	administration|nmod|START_ENTITY administration|appos|END_ENTITY	Weekly administration of irinotecan -LRB- CPT-11 -RRB- plus cisplatin for non-small_cell_lung_cancer .
12391279	0	cisplatin	38,47	CTR1	23,27	cisplatin	CTR1	MESH:D002945	856241(Tax:4932)	Chemical	Gene	uptake|compound|START_ENTITY regulates|dobj|uptake regulates|nsubj|END_ENTITY	The copper transporter CTR1 regulates cisplatin uptake in Saccharomyces_cerevisiae .
14732223	6	cisplatin	838,847	Clusterin	782,791	cisplatin	Clusterin	MESH:D002945	1191	Chemical	Gene	increased|nmod|START_ENTITY increased|nsubjpass|expression expression|compound|END_ENTITY	Clusterin expression was increased after treatment with cisplatin and highest at 8 h in 253J cells .
24522273	0	cisplatin	71,80	Copper_transporter_2	0,20	cisplatin	Copper transporter 2	MESH:D002945	1318	Chemical	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Copper_transporter_2 regulates intracellular copper and sensitivity to cisplatin .
19144690	0	cisplatin	43,52	Ctr1	23,27	cisplatin	Ctr1	MESH:D002945	20529(Tax:10090)	Chemical	Gene	contributes|xcomp|START_ENTITY contributes|nsubj|END_ENTITY	The copper transporter Ctr1 contributes to cisplatin uptake by renal tubular cells during cisplatin nephrotoxicity .
26698249	0	cisplatin	18,27	Cyclin_I	0,8	cisplatin	Cyclin I	MESH:D002945	10983	Chemical	Gene	resistance|compound|START_ENTITY promotes|dobj|resistance promotes|nsubj|END_ENTITY	Cyclin_I promotes cisplatin resistance via Cdk5 activation in cervical_cancer .
19372586	0	cisplatin	148,157	DNA-PK	173,179	cisplatin	DNA-PK	MESH:D002945	5591	Chemical	Gene	sensitivity|compound|START_ENTITY sensitivity|nmod|END_ENTITY	DNA-dependent_protein_kinase -LRB- DNA-PK -RRB- - dependent cisplatin-induced loss of nucleolar facilitator of chromatin transcription -LRB- FACT -RRB- and regulation of cisplatin sensitivity by DNA-PK and FACT .
15138368	0	cisplatin	114,123	E-cadherin	31,41	cisplatin	E-cadherin	MESH:D002945	999	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of wild-type and mutant E-cadherin on cell proliferation and responsiveness to the chemotherapeutic agents cisplatin , etoposide , and 5-fluorouracil .
27016414	0	cisplatin	86,95	E-cadherin	120,130	cisplatin	E-cadherin	MESH:D002945	999	Chemical	Gene	resistance|compound|START_ENTITY induces|dobj|resistance induces|advcl|targeting targeting|xcomp|END_ENTITY	MicroRNA-421 regulated by HIF-1a promotes metastasis , inhibits apoptosis , and induces cisplatin resistance by targeting E-cadherin and caspase-3 in gastric_cancer .
7520221	0	cisplatin	114,123	EAP	86,89	cisplatin	EAP	MESH:D002945	2028	Chemical	Gene	therapy|appos|START_ENTITY therapy|compound|END_ENTITY	-LSB- A case of AFP -LRB- alpha-fetoprotein -RRB- producing gastric_cancer successfully treated with EAP -LRB- etoposide , adriamycin , cisplatin -RRB- therapy -RSB- .
24606472	0	cisplatin	106,115	ECRG2	80,85	cisplatin	ECRG2	MESH:D002945	84651	Chemical	Gene	apoptosis|nmod|START_ENTITY apoptosis|nmod|END_ENTITY	Expression of bcl-2 and p53 in induction of esophageal_cancer cell apoptosis by ECRG2 in combination with cisplatin .
25289046	0	cisplatin	36,45	ECRG2	10,15	cisplatin	ECRG2	MESH:D002945	84651	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of ECRG2 in combination with cisplatin on the proliferation and apoptosis of EC9706 cells .
11391854	2	cisplatin	411,420	EGF	349,352	cisplatin	EGF	MESH:D002945	1950	Chemical	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	We now investigated the mechanisms by which EGF enhances the sensitivity of human ovarian_cancer cells to cisplatin .
10741696	0	cisplatin	91,100	ERCC1	14,19	cisplatin	ERCC1	MESH:D002945	2067	Chemical	Gene	abrogates|nmod|START_ENTITY abrogates|nsubj|Expression Expression|nmod|RNA RNA|compound|END_ENTITY	Expression of ERCC1 antisense RNA abrogates gemicitabine-mediated cytotoxic synergism with cisplatin in human colon_tumor cells defective in mismatch repair but proficient in nucleotide excision repair .
11008208	0	cisplatin	42,51	ERCC1	0,5	cisplatin	ERCC1	MESH:D002945	2067	Chemical	Gene	resistance|compound|START_ENTITY marker|nmod|resistance expression|nmod|marker expression|nummod|END_ENTITY	ERCC1 expression as a molecular marker of cisplatin resistance in human cervical_tumor cells .
12114432	0	cisplatin	62,71	ERCC1	4,9	cisplatin	ERCC1	MESH:D002945	2067	Chemical	Gene	survival|nmod|START_ENTITY correlates|nmod|survival correlates|nsubj|expression expression|compound|END_ENTITY	Low ERCC1 expression correlates with prolonged survival after cisplatin plus gemcitabine chemotherapy in non-small_cell_lung_cancer .
12202770	0	cisplatin	114,123	ERCC1	91,96	cisplatin	ERCC1	MESH:D002945	100689377	Chemical	Gene	account|nmod|START_ENTITY account|nmod|sensitivity sensitivity|nmod|cells cells|compound|END_ENTITY	Defects in interstrand cross-link uncoupling do not account for the extreme sensitivity of ERCC1 and XPF cells to cisplatin .
15140544	0	cisplatin	116,125	ERCC1	37,42	cisplatin	ERCC1	MESH:D002945	2067	Chemical	Gene	chemotherapy|amod|START_ENTITY treated|nmod|chemotherapy treated|nsubj|Association Association|nmod|polymorphisms polymorphisms|nmod|END_ENTITY	Association between polymorphisms of ERCC1 and XPD and survival in non-small-cell_lung_cancer patients treated with cisplatin combination chemotherapy .
15629453	0	cisplatin	97,106	ERCC1	45,50	cisplatin	ERCC1	MESH:D002945	2067	Chemical	Gene	enhances|nmod|START_ENTITY enhances|nsubj|Small Small|acl|interfering interfering|dobj|suppression suppression|nmod|END_ENTITY	Small interfering RNA-induced suppression of ERCC1 enhances sensitivity of human cancer cells to cisplatin .
16756962	0	cisplatin	47,56	ERCC1	107,112	cisplatin	ERCC1	MESH:D002945	2067	Chemical	Gene	chemosensitising|nmod|START_ENTITY XPA|acl|chemosensitising XPA|dep|role role|nmod|END_ENTITY	XPA versus ERCC1 as chemosensitising agents to cisplatin and mitomycin_C in prostate_cancer cells : role of ERCC1 in homologous recombination repair .
16980606	0	cisplatin	132,141	ERCC1	0,5	cisplatin	ERCC1	MESH:D002945	2067	Chemical	Gene	treated|nmod|START_ENTITY non-small-cell_lung_cancer|acl|treated survival|nmod|non-small-cell_lung_cancer predictive|nmod|survival predictive|nsubj|END_ENTITY	ERCC1 and RRM1 gene expressions but not EGFR are predictive of shorter survival in advanced non-small-cell_lung_cancer treated with cisplatin and gemcitabine .
18402708	0	cisplatin	112,121	ERCC1	0,5	cisplatin	ERCC1	MESH:D002945	2067	Chemical	Gene	associated|xcomp|START_ENTITY associated|nsubjpass|levels levels|compound|END_ENTITY	ERCC1 and BRCA1 mRNA expression levels in metastatic malignant effusions is associated with chemosensitivity to cisplatin and/or docetaxel .
18640939	0	cisplatin	164,173	ERCC1	21,26	cisplatin	ERCC1	MESH:D002945	2067	Chemical	Gene	intraperitoneal|nmod|START_ENTITY Trial|nmod|intraperitoneal Phase|dobj|Trial Phase|nsubj|Relationship Relationship|nmod|polymorphisms polymorphisms|nummod|END_ENTITY	Relationship between ERCC1 polymorphisms , disease progression , and survival in the Gynecologic Oncology Group Phase III Trial of intraperitoneal versus intravenous cisplatin and paclitaxel for stage_III_epithelial_ovarian_cancer .
18645262	0	cisplatin	31,40	ERCC1	102,107	cisplatin	ERCC1	MESH:D002945	2067	Chemical	Gene	resistance|compound|START_ENTITY enhances|dobj|resistance enhances|nmod|regulation regulation|nmod|END_ENTITY	Upregulation of ZNRD1 enhances cisplatin resistance in human esophageal_cancer cells by regulation of ERCC1 and Bcl-2 .
18756932	0	cisplatin	78,87	ERCC1	54,59	cisplatin	ERCC1	MESH:D002945	2067	Chemical	Gene	repair|advcl|START_ENTITY repair|dobj|END_ENTITY	-LSB- Relationship between nucleotide excision repair gene ERCC1 and resistance to cisplatin in ovarian_cancer -RSB- .
19626585	0	cisplatin	62,71	ERCC1	8,13	cisplatin	ERCC1	MESH:D002945	2067	Chemical	Gene	hypermethylation|nmod|START_ENTITY hypermethylation|nsubj|Role Role|nmod|promoter promoter|compound|END_ENTITY	Role of ERCC1 promoter hypermethylation in drug resistance to cisplatin in human gliomas .
21076943	0	cisplatin	35,44	ERCC1	14,19	cisplatin	ERCC1	MESH:D002945	2067	Chemical	Gene	sensitivity|compound|START_ENTITY Evaluation|nmod|sensitivity Evaluation|nmod|expression expression|compound|END_ENTITY	Evaluation of ERCC1 expression for cisplatin sensitivity in human hepatocellular_carcinoma .
21126401	7	cisplatin	1065,1074	ERCC1	1102,1107	cisplatin	ERCC1	MESH:D002945	2067	Chemical	Gene	treating|nmod|START_ENTITY observed|advcl|treating observed|nsubjpass|up-regulation up-regulation|nmod|mRNA mRNA|compound|END_ENTITY	After treating with 5 mol/L cisplatin for 24 h , up-regulation of ERCC1 mRNA and protein was observed in A549 cells , and when treated with 20 mol/L cisplatin for 24 h , the ERCC1 mRNA and protein reached the peak levels .
22031231	0	cisplatin	69,78	ERCC1	4,9	cisplatin	ERCC1	MESH:D002945	2067	Chemical	Gene	treated|nmod|START_ENTITY pleural_mesotheliomas|acl|treated expression|nmod|pleural_mesotheliomas expression|compound|END_ENTITY	Low ERCC1 expression in malignant pleural_mesotheliomas treated with cisplatin and vinorelbine predicts prolonged progression-free survival .
22102173	0	cisplatin	46,55	ERCC1	24,29	cisplatin	ERCC1	MESH:D002945	2067	Chemical	Gene	polymorphism|acl|START_ENTITY polymorphism|nmod|END_ENTITY	A C118T polymorphism of ERCC1 and response to cisplatin chemotherapy in patients with late-stage non-small_cell_lung_cancer .
22199271	0	cisplatin	78,87	ERCC1	0,5	cisplatin	ERCC1	MESH:D002945	2067	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|expression expression|compound|END_ENTITY	ERCC1 expression and outcomes in head_and_neck_cancer treated with concurrent cisplatin and radiation .
22266184	0	cisplatin	45,54	ERCC1	73,78	cisplatin	ERCC1	MESH:D002945	2067	Chemical	Gene	START_ENTITY|nmod|modulation modulation|nmod|expression expression|nummod|END_ENTITY	Sunitinib synergizes the antitumor effect of cisplatin via modulation of ERCC1 expression in models of gastric_cancer .
24058603	0	cisplatin	173,182	ERCC1	27,32	cisplatin	ERCC1	MESH:D002945	2067	Chemical	Gene	received|nmod|START_ENTITY IIA|acl:relcl|received TOP|dobj|IIA TOP|nsubj|value value|nmod|TOPOI TOPOI|appos|END_ENTITY	Predictive value of BRCA1 , ERCC1 , ATP7B , PKM2 , TOPOI , TOP - IIA , TOPOIIB and C-MYC genes in patients with small_cell_lung_cancer -LRB- SCLC -RRB- who received first line therapy with cisplatin and etoposide .
24699918	0	cisplatin	43,52	ERCC1	0,5	cisplatin	ERCC1	MESH:D002945	2067	Chemical	Gene	ameliorates|advcl|START_ENTITY ameliorates|nsubj|siRNA siRNA|compound|END_ENTITY	ERCC1 siRNA ameliorates drug resistance to cisplatin in gastric_carcinoma cell lines .
25083297	0	cisplatin	136,145	ERCC1	80,85	cisplatin	ERCC1	MESH:D002945	2067	Chemical	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Breast_cancer_resistance_protein -LRB- BCRP -RRB- and excision_repair_cross_complement-1 -LRB- ERCC1 -RRB- expression in esophageal_cancers and response to cisplatin and irinotecan based chemotherapy .
26384430	0	cisplatin	44,53	ERCC1	121,126	cisplatin	ERCC1	MESH:D002945	2067	Chemical	Gene	START_ENTITY|advcl|inhibiting inhibiting|dobj|trans-activation trans-activation|nmod|gene gene|compound|END_ENTITY	CITED2 silencing sensitizes cancer cells to cisplatin by inhibiting p53 trans-activation and chromatin relaxation on the ERCC1 DNA repair gene .
26557761	0	cisplatin	106,115	ERCC1	0,5	cisplatin	ERCC1	MESH:D002945	2067	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|END_ENTITY	ERCC1 and RRM1 as a predictive parameter for non-small_cell_lung , _ ovarian_or_pancreas_cancer treated with cisplatin and/or gemcitabine .
9440758	0	cisplatin	148,157	ERCC1	0,5	cisplatin	ERCC1	MESH:D002945	2067	Chemical	Gene	receiving|dobj|START_ENTITY patients|acl|receiving predicting|nmod|patients complement|advcl|predicting complement|nsubj|levels levels|compound|END_ENTITY	ERCC1 mRNA levels complement thymidylate_synthase mRNA levels in predicting response and survival for gastric_cancer patients receiving combination cisplatin and fluorouracil chemotherapy .
26935606	0	cisplatin	54,63	ERG	35,38	cisplatin	ERG	MESH:D002945	2078	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Functional analysis of the TMPRSS2 : ERG fusion gene in cisplatin - induced cell death .
16154539	0	cisplatin	37,46	ERK	95,98	cisplatin	ERK	MESH:D002945	24338(Tax:10116)	Chemical	Gene	nephrotoxicity|compound|START_ENTITY attenuates|dobj|nephrotoxicity attenuates|advcl|suppressing suppressing|dobj|activation activation|compound|END_ENTITY	Serum thymic factor , FTS , attenuates cisplatin nephrotoxicity by suppressing cisplatin-induced ERK activation .
17203222	0	cisplatin	52,61	ERK	87,90	cisplatin	ERK	MESH:D002945	5594	Chemical	Gene	START_ENTITY|dep|activation activation|nmod|END_ENTITY	STI571 sensitizes nasopharyngeal_carcinoma cells to cisplatin : sustained activation of ERK with improved growth inhibition .
21687949	0	cisplatin	25,34	ERK	124,127	cisplatin	ERK	MESH:D002945	5594	Chemical	Gene	sensitizes|dobj|START_ENTITY sensitizes|nmod|down-regulation down-regulation|nmod|END_ENTITY	Tubeimoside_I sensitizes cisplatin in cisplatin-resistant human ovarian_cancer cells -LRB- A2780/DDP -RRB- through down-regulation of ERK and up-regulation of p38 signaling pathways .
26260159	0	cisplatin	88,97	ERK	135,138	cisplatin	ERK	MESH:D002945	5594	Chemical	Gene	effects|nmod|START_ENTITY augments|dobj|effects augments|nmod|cells cells|nmod|activation activation|compound|END_ENTITY	Moxifloxacin and ciprofloxacin induces S-phase arrest and augments apoptotic effects of cisplatin in human pancreatic_cancer cells via ERK activation .
2243136	0	cisplatin	95,104	Epidermal_growth_factor	0,23	cisplatin	Epidermal growth factor	MESH:D002945	1950	Chemical	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Epidermal_growth_factor regulates the in vitro sensitivity of human ovarian_carcinoma cells to cisplatin .
24185104	0	cisplatin	36,45	Erk	79,82	cisplatin	Erk	MESH:D002945	5594	Chemical	Gene	resistance|compound|START_ENTITY RhoGDI2-induced|dobj|resistance RhoGDI2-induced|nmod|activation activation|nmod|END_ENTITY	14-3-3 attenuates RhoGDI2-induced cisplatin resistance through activation of Erk and p38 in gastric_cancer cells .
19259045	0	cisplatin	54,63	Erythropoietin	0,14	cisplatin	Erythropoietin	MESH:D002945	24335(Tax:10116)	Chemical	Gene	reduces|nmod|START_ENTITY reduces|nsubj|END_ENTITY	Erythropoietin reduces cumulative nephrotoxicity from cisplatin and enhances renal tubular cell proliferation .
9466500	0	cisplatin	37,46	Erythropoietin	0,14	cisplatin	Erythropoietin	MESH:D002945	24335(Tax:10116)	Chemical	Gene	anemia|nmod|START_ENTITY ameliorates|dobj|anemia ameliorates|nsubj|END_ENTITY	Erythropoietin ameliorates anemia of cisplatin induced acute_renal_failure .
25251256	0	cisplatin	23,32	Ewing_sarcoma	79,92	cisplatin	Ewing sarcoma	MESH:D002945	2130	Chemical	Gene	therapy|compound|START_ENTITY therapy|nmod|END_ENTITY	Etoposide and carbo-or cisplatin combination therapy in refractory or relapsed Ewing_sarcoma : A large retrospective study .
24824601	0	cisplatin	16,25	FOXM1	0,5	cisplatin	FOXM1	MESH:D002945	2305	Chemical	Gene	sensitivity|compound|START_ENTITY modulates|dobj|sensitivity modulates|nsubj|END_ENTITY	FOXM1 modulates cisplatin sensitivity by regulating EXO1 in ovarian_cancer .
24202965	0	cisplatin	49,58	FOXO1	34,39	cisplatin	FOXO1	MESH:D002945	2308	Chemical	Gene	resistance|compound|START_ENTITY mediates|dobj|resistance mediates|nsubj|END_ENTITY	The forkhead transcription factor FOXO1 mediates cisplatin resistance in gastric_cancer cells by activating phosphoinositide 3-kinase/Akt pathway .
18852127	0	cisplatin	41,50	FOXO3a	0,6	cisplatin	FOXO3a	MESH:D002945	2309	Chemical	Gene	effects|nmod|START_ENTITY mediates|dobj|effects mediates|nsubj|END_ENTITY	FOXO3a mediates the cytotoxic effects of cisplatin in colon_cancer cells .
24814195	0	cisplatin	41,50	FOXO3a	0,6	cisplatin	FOXO3a	MESH:D002945	2309	Chemical	Gene	effects|nmod|START_ENTITY mediates|dobj|effects mediates|nsubj|END_ENTITY	FOXO3a mediates the cytotoxic effects of cisplatin in lung_cancer cells .
24814195	6	cisplatin	877,886	FOXO3a	911,917	cisplatin	FOXO3a	MESH:D002945	2309	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|dobj|phosphorylation phosphorylation|amod|END_ENTITY	More importantly , cisplatin significantly inhibited FOXO3a phosphorylation -LRB- at Thr32 , AKT phosphorylation site -RRB- and induced FOXO3a nuclear accumulation , which in turn increased the expression of FOXO3a-dependent apoptotic protein Bim .
19225146	0	cisplatin	19,28	Fos	42,45	cisplatin	Fos	MESH:D002945	2353	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Chemotherapy agent cisplatin induces 48-h Fos expression in the brain of a vomiting species , the house musk shrew -LRB- Suncus murinus -RRB- .
19362521	0	cisplatin	55,64	Fos	6,9	cisplatin	Fos	MESH:D002945	314322(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY expression|acl|induced expression|compound|END_ENTITY	Brain Fos expression induced by the chemotherapy agent cisplatin in the rat is partially dependent on an intact abdominal vagus .
20210796	0	cisplatin	81,90	Foxo3a	0,6	cisplatin	Foxo3a	MESH:D002945	2309	Chemical	Gene	regulate|xcomp|START_ENTITY regulate|nsubj|expression expression|compound|END_ENTITY	Foxo3a expression and acetylation regulate cancer cell growth and sensitivity to cisplatin .
24926795	0	cisplatin	43,52	Gli1	0,4	cisplatin	Gli1	MESH:D002945	2735	Chemical	Gene	contributes|xcomp|START_ENTITY contributes|nsubj|END_ENTITY	Gli1 contributes to cellular resistance to cisplatin through altered cellular accumulation of the drug .
21421285	0	cisplatin	60,69	HIF-1a	92,98	cisplatin	HIF-1a	MESH:D002945	3091	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Noscapine sensitizes chemoresistant ovarian_cancer cells to cisplatin through inhibition of HIF-1a .
24155936	0	cisplatin	45,54	HOTAIR	23,29	cisplatin	HOTAIR	MESH:D002945	100124700	Chemical	Gene	contributes|xcomp|START_ENTITY contributes|nsubj|END_ENTITY	The long noncoding RNA HOTAIR contributes to cisplatin resistance of human lung_adenocarcinoma cells via downregualtion of p21 -LRB- WAF1/CIP1 -RRB- expression .
24317439	0	cisplatin	87,96	HSP90	4,9	cisplatin	HSP90	MESH:D002945	3320	Chemical	Gene	inhibitor|nmod|START_ENTITY inhibitor|nsubj|END_ENTITY	The HSP90 inhibitor 17-N-allylamino-17-demethoxy_geldanamycin -LRB- 17-AAG -RRB- synergizes with cisplatin and induces apoptosis in cisplatin-resistant esophageal_squamous_cell_carcinoma cell lines via the Akt/XIAP pathway .
12476615	0	cisplatin	14,23	Hsp72	52,57	cisplatin	Hsp72	MESH:D002945	3303	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|amod|END_ENTITY	The effect of cisplatin , etoposide and quercetin on Hsp72 expression .
10362102	0	cisplatin	46,55	ICAM-1	25,31	cisplatin	ICAM-1	MESH:D002945	3383	Chemical	Gene	induction|nmod|START_ENTITY induction|nmod|expression expression|compound|END_ENTITY	Synergistic induction of ICAM-1 expression by cisplatin and 5-fluorouracil in a cancer cell line via a NF-kappaB independent pathway .
1612637	0	cisplatin	75,84	IL-2	17,21	cisplatin	IL-2	MESH:D002945	3558	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Up-regulation of IL-2 induced lymphokine activated killer cell activity by cisplatin and FK-565 : involvement of calcium ion .
21304406	0	cisplatin	42,51	Interleukin-28B	0,15	cisplatin	Interleukin-28B	MESH:D002945	338374(Tax:10090)	Chemical	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	Interleukin-28B acts synergistically with cisplatin to suppress the growth of head_and_neck_squamous_cell_carcinoma .
21557940	0	cisplatin	77,86	JAK2	90,94	cisplatin	JAK2	MESH:D002945	16452(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Aurora_kinase_A critically contributes to the resistance to anti-cancer drug cisplatin in JAK2 V617F mutant-induced transformed cells .
10098743	0	cisplatin	41,50	JNK	13,16	cisplatin	JNK	MESH:D002945	5599	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of JNK and c-Abl signalling by cisplatin and oxaliplatin in mismatch repair-proficient and - deficient cells .
11064451	0	cisplatin	66,75	JNK	22,25	cisplatin	JNK	MESH:D002945	5599	Chemical	Gene	modulates|nmod|START_ENTITY modulates|dobj|activation activation|compound|END_ENTITY	CL100/MKP -1 modulates JNK activation and apoptosis in response to cisplatin .
23045278	0	cisplatin	38,47	KEAP1	18,23	cisplatin	KEAP1	MESH:D002945	9817	Chemical	Gene	sensitivity|compound|START_ENTITY sensitivity|compound|END_ENTITY	miR-141 regulates KEAP1 and modulates cisplatin sensitivity in ovarian_cancer cells .
22576699	0	cisplatin	29,38	LKB1	80,84	cisplatin	LKB1	MESH:D002945	6794	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Enhanced antitumor effect of cisplatin in human NSCLC cells by tumor suppressor LKB1 .
12216079	0	cisplatin	65,74	MDR1	166,170	cisplatin	MDR1	MESH:D002945	5243	Chemical	Gene	triphosphatase|nmod|START_ENTITY triphosphatase|dep|analysis analysis|nmod|expression expression|nmod|END_ENTITY	Copper-transporting P-type adenosine triphosphatase -LRB- ATP7B -RRB- as a cisplatin based chemoresistance marker in ovarian_carcinoma : comparative analysis with expression of MDR1 , MRP1 , MRP2 , LRP and BCRP .
12576681	0	cisplatin	49,58	MDR1	17,21	cisplatin	MDR1	MESH:D002945	396910(Tax:9823)	Chemical	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|function function|compound|END_ENTITY	Up-regulation of MDR1 function and expression by cisplatin in LLC-PK1 cells .
18231753	0	cisplatin	43,52	MDR1	0,4	cisplatin	MDR1	MESH:D002945	5243	Chemical	Gene	genes|nmod|START_ENTITY genes|compound|END_ENTITY	MDR1 and MDR3 genes and drug resistance to cisplatin of ovarian_cancer cells .
20627363	0	cisplatin	129,138	MDR1	35,39	cisplatin	MDR1	MESH:D002945	5243	Chemical	Gene	treated|nmod|START_ENTITY patients|acl|treated outcome|nmod|patients correlates|nmod|outcome correlates|nsubj|polymorphisms polymorphisms|nmod|gen gen|compound|END_ENTITY	Single nucleotide polymorphisms in MDR1 gen correlates with outcome in advanced non-small-cell_lung_cancer patients treated with cisplatin plus vinorelbine .
22432540	0	cisplatin	76,85	MDR1	24,28	cisplatin	MDR1	MESH:D002945	5243	Chemical	Gene	treatment|compound|START_ENTITY combined|dobj|treatment combined|nsubj|expression expression|nmod|END_ENTITY	Decreased expression of MDR1 in PEG-conjugated hemoglobin solution combined cisplatin treatment in a tumor xenograft model .
23907215	0	cisplatin	70,79	MDR1	107,111	cisplatin	MDR1	MESH:D002945	18669(Tax:10090)	Chemical	Gene	resistance|compound|START_ENTITY enhances|dobj|resistance enhances|advcl|upregulating upregulating|dobj|expression expression|compound|END_ENTITY	Expression of aryl_hydrocarbon_receptor_nuclear_translocator enhances cisplatin resistance by upregulating MDR1 expression in cancer cells .
25579168	0	cisplatin	64,73	MDR1	98,102	cisplatin	MDR1	MESH:D002945	5243	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Sorafenib reverses resistance of gastric_cancer to treatment by cisplatin through down-regulating MDR1 expression .
26717965	0	cisplatin	47,56	MDR1	7,11	cisplatin	MDR1	MESH:D002945	5243	Chemical	Gene	chemoresistance|xcomp|START_ENTITY confers|xcomp|chemoresistance confers|nsubj|END_ENTITY	HIF-1a / MDR1 pathway confers chemoresistance to cisplatin in bladder_cancer .
11996883	0	cisplatin	64,73	MEK	95,98	cisplatin	MEK	MESH:D002945	5609	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Increase of the resistance of human cervical_carcinoma cells to cisplatin by inhibition of the MEK to ERK signaling pathway partly via enhancement of anticancer drug-induced NF_kappa_B activation .
26689986	0	cisplatin	60,69	MKP1	0,4	cisplatin	MKP1	MESH:D002945	1843	Chemical	Gene	mediates|xcomp|START_ENTITY mediates|nsubj|END_ENTITY	MKP1 mediates chemosensitizer effects of E1a in response to cisplatin in non-small_cell_lung_carcinoma cells .
9219724	0	cisplatin	10,19	MMP-2	32,37	cisplatin	MMP-2	MESH:D002945	4313	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|compound|END_ENTITY	Effect of cisplatin and BCNU on MMP-2 levels in human glioblastoma cell lines in vitro .
21285347	0	cisplatin	58,67	MSH3	0,4	cisplatin	MSH3	MESH:D002945	4437	Chemical	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	MSH3 mediates sensitization of colorectal_cancer cells to cisplatin , oxaliplatin , and a poly -LRB- ADP-ribose -RRB- polymerase inhibitor .
17457342	0	cisplatin	83,92	Megalin	0,7	cisplatin	Megalin	MESH:D002945	4036	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nmod|effect	Megalin genetic polymorphisms and individual sensitivity to the ototoxic effect of cisplatin .
22996741	0	cisplatin	57,66	MiR-155	0,7	cisplatin	MiR-155	MESH:D002945	406947	Chemical	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	MiR-155 inhibits the sensitivity of lung_cancer cells to cisplatin via negative regulation of Apaf-1 expression .
25888377	0	cisplatin	21,30	MiR-223	0,7	cisplatin	MiR-223	MESH:D002945	407008	Chemical	Gene	resistance|compound|START_ENTITY promotes|dobj|resistance promotes|nsubj|END_ENTITY	MiR-223 promotes the cisplatin resistance of human gastric_cancer cells via regulating cell cycle by targeting FBXW7 .
25888377	0	cisplatin	21,30	MiR-223	0,7	cisplatin	MiR-223	MESH:D002945	407008	Chemical	Gene	resistance|compound|START_ENTITY promotes|dobj|resistance promotes|nsubj|END_ENTITY	MiR-223 promotes the cisplatin resistance of human gastric_cancer cells via regulating cell cycle by targeting FBXW7 .
24921914	0	cisplatin	75,84	MiR-224	0,7	cisplatin	MiR-224	MESH:D002945	407009	Chemical	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	MiR-224 promotes the chemoresistance of human lung_adenocarcinoma cells to cisplatin via regulating G / S transition and apoptosis by targeting p21 -LRB- WAF1/CIP1 -RRB- .
25490686	0	cisplatin	75,84	MiR-224	0,7	cisplatin	MiR-224	MESH:D002945	407009	Chemical	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	MiR-224 promotes the chemoresistance of human lung_adenocarcinoma cells to cisplatin via regulating G1/S transition and apoptosis by targeting p21WAF1/CIP1 .
26458859	0	cisplatin	60,69	MiR-26a	0,7	cisplatin	MiR-26a	MESH:D002945	407015	Chemical	Gene	enhances|xcomp|START_ENTITY enhances|nsubj|END_ENTITY	MiR-26a enhances the sensitivity of gastric_cancer cells to cisplatin by targeting NRAS and E2F2 .
21273587	0	cisplatin	31,40	NK4	0,3	cisplatin	NK4	MESH:D002945	9235	Chemical	Gene	therapy|nmod|START_ENTITY therapy|compound|END_ENTITY	NK4 gene therapy combined with cisplatin inhibits tumour growth and metastasis of squamous_cell_carcinoma .
25772757	0	cisplatin	41,50	OCT6	27,31	cisplatin	OCT6	MESH:D002945	85413	Chemical	Gene	uptake|amod|START_ENTITY mediates|dobj|uptake mediates|nsubj|END_ENTITY	Organic cation transporter OCT6 mediates cisplatin uptake and resistance to cisplatin in lung_cancer .
25772757	0	cisplatin	76,85	OCT6	27,31	cisplatin	OCT6	MESH:D002945	85413	Chemical	Gene	mediates|advcl|START_ENTITY mediates|nsubj|END_ENTITY	Organic cation transporter OCT6 mediates cisplatin uptake and resistance to cisplatin in lung_cancer .
23649842	0	cisplatin	95,104	Organic_anion_transporter_5	0,27	cisplatin	Organic anion transporter 5	MESH:D002945	286961(Tax:10116)	Chemical	Gene	treated|nmod|START_ENTITY END_ENTITY|acl:relcl|treated	Organic_anion_transporter_5 -LRB- Oat5 -RRB- renal expression and urinary excretion in rats treated with cisplatin : a potential biomarker of cisplatin-induced nephrotoxicity .
27049263	0	cisplatin	99,108	P-glycoprotein	142,156	cisplatin	P-glycoprotein	MESH:D002945	5243	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Inhibition of the JNK signaling pathway increases sensitivity of hepatocellular_carcinoma cells to cisplatin by down-regulating expression of P-glycoprotein .
11245458	0	cisplatin	145,154	P53	0,3	cisplatin	P53	MESH:D002945	7157	Chemical	Gene	effects|nmod|START_ENTITY modulates|nmod|effects modulates|nsubj|END_ENTITY	P53 modulates the effect of loss of DNA mismatch repair on the sensitivity of human colon_cancer cells to the cytotoxic and mutagenic effects of cisplatin .
12884349	0	cisplatin	29,38	P53	0,3	cisplatin	P53	MESH:D002945	7157	Chemical	Gene	sensitivity|compound|START_ENTITY correlates|nmod|sensitivity correlates|nsubj|mutation mutation|compound|END_ENTITY	P53 mutation correlates with cisplatin sensitivity in head_and_neck_squamous_cell_carcinoma lines .
18504201	0	cisplatin	48,57	P53	1,4	cisplatin	P53	MESH:D002945	7157	Chemical	Gene	protein|nmod|START_ENTITY protein|nsubj|END_ENTITY	-LSB- P53 protein expression and chemosensitivity to cisplatin in patients with non-small_cell_lung_cancer : a meta-analysis -RSB- .
18558085	0	cisplatin	76,85	P53	98,101	cisplatin	P53	MESH:D002945	22060(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|advcl|reducing reducing|dobj|accumulation accumulation|compound|END_ENTITY	Ursodeoxycholic_acid prevents apoptosis of mouse sensory neurons induced by cisplatin by reducing P53 accumulation .
10974930	0	cisplatin	81,90	PCNA	14,18	cisplatin	PCNA	MESH:D002945	5111	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of PCNA in non-small_cell_lung_cancer before and after treatment with cisplatin and vepeside .
25006250	0	cisplatin	34,43	PI3K	79,83	cisplatin	PI3K	MESH:D002945	5293	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Synergistic therapeutic effect of cisplatin and phosphatidylinositol_3-kinase -LRB- PI3K -RRB- inhibitors in cancer growth and metastasis of Brca1 mutant tumors .
22403741	0	cisplatin	60,69	PKC	51,54	cisplatin	PKC	MESH:D002945	112476	Chemical	Gene	treatment|compound|START_ENTITY END_ENTITY|nmod|treatment	Curtailing side effects in chemotherapy : a tale of PKC in cisplatin treatment .
24058603	0	cisplatin	173,182	PKM2	41,45	cisplatin	PKM2	MESH:D002945	5315	Chemical	Gene	received|nmod|START_ENTITY IIA|acl:relcl|received TOP|dobj|IIA TOP|nsubj|value value|nmod|TOPOI TOPOI|appos|END_ENTITY	Predictive value of BRCA1 , ERCC1 , ATP7B , PKM2 , TOPOI , TOP - IIA , TOPOIIB and C-MYC genes in patients with small_cell_lung_cancer -LRB- SCLC -RRB- who received first line therapy with cisplatin and etoposide .
23351152	0	cisplatin	18,27	PRIMA-1	0,7	cisplatin	PRIMA-1	MESH:D002945	145270	Chemical	Gene	sensitivity|compound|START_ENTITY sensitivity|compound|END_ENTITY	PRIMA-1 increases cisplatin sensitivity in chemoresistant ovarian_cancer cells with p53 mutation : a requirement for Akt down-regulation .
11707646	0	cisplatin	15,24	PTEN	78,82	cisplatin	PTEN	MESH:D002945	5728	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of cisplatin , paclitaxel and adriamycin with the tumor suppressor PTEN .
15790433	0	cisplatin	94,103	PTEN	34,38	cisplatin	PTEN	MESH:D002945	5728	Chemical	Gene	contributes|xcomp|START_ENTITY contributes|nsubj|Activation Activation|nmod|pathway pathway|nmod|reduction reduction|compound|END_ENTITY	Activation of PI3K/Akt pathway by PTEN reduction and PIK3CA mRNA amplification contributes to cisplatin resistance in an ovarian_cancer cell line .
18657898	0	cisplatin	58,67	PTEN	32,36	cisplatin	PTEN	MESH:D002945	5728	Chemical	Gene	resistance|acl|START_ENTITY END_ENTITY|nmod|resistance	Effect of tumor suppressor gene PTEN on the resistance to cisplatin in human ovarian_cancer cell lines and related mechanisms .
23466500	0	cisplatin	15,24	PTEN	74,78	cisplatin	PTEN	MESH:D002945	5728	Chemical	Gene	resistance|compound|START_ENTITY confers|dobj|resistance confers|advcl|regulating regulating|dobj|END_ENTITY	miR-21 confers cisplatin resistance in gastric_cancer cells by regulating PTEN .
23470565	0	cisplatin	73,82	PTEN	41,45	cisplatin	PTEN	MESH:D002945	5728	Chemical	Gene	chemotherapy|compound|START_ENTITY combined|nmod|chemotherapy combined|nsubj|suppression suppression|nmod|therapy therapy|compound|END_ENTITY	Enhanced tumor suppression by adenoviral PTEN gene therapy combined with cisplatin chemotherapy in small-cell_lung_cancer .
26125866	0	cisplatin	74,83	PTEN	50,54	cisplatin	PTEN	MESH:D002945	5728	Chemical	Gene	resistance|compound|START_ENTITY improves|dobj|resistance improves|nsubj|overexpression overexpression|nmod|END_ENTITY	Recombinant adenovirus-mediated overexpression of PTEN and KRT10 improves cisplatin resistance of ovarian_cancer in vitro and in vivo .
26365986	0	cisplatin	20,29	PTEN	54,58	cisplatin	PTEN	MESH:D002945	5728	Chemical	Gene	resistance|compound|START_ENTITY induces|dobj|resistance induces|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-24 induces cisplatin resistance by targeting PTEN in human tongue_squamous_cell_carcinoma .
18927497	0	cisplatin	31,40	Puralpha	19,27	cisplatin	Puralpha	MESH:D002945	19290(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Protective role of Puralpha to cisplatin .
19289490	0	cisplatin	33,42	REV3L	0,5	cisplatin	REV3L	MESH:D002945	5980	Chemical	Gene	chemoresistance|xcomp|START_ENTITY confers|xcomp|chemoresistance confers|nsubj|END_ENTITY	REV3L confers chemoresistance to cisplatin in human gliomas : the potential of its RNAi for synergistic therapy .
26165320	0	cisplatin	16,25	REV3L	0,5	cisplatin	REV3L	MESH:D002945	5980	Chemical	Gene	sensitivity|compound|START_ENTITY modulates|dobj|sensitivity modulates|nsubj|END_ENTITY	REV3L modulates cisplatin sensitivity of non-small cell lung_cancer H1299 cells .
26165320	0	cisplatin	16,25	REV3L	0,5	cisplatin	REV3L	MESH:D002945	5980	Chemical	Gene	sensitivity|compound|START_ENTITY modulates|dobj|sensitivity modulates|nsubj|END_ENTITY	REV3L modulates cisplatin sensitivity of non-small cell lung_cancer H1299 cells .
24675421	0	cisplatin	77,86	RIP1	68,72	cisplatin	RIP1	MESH:D002945	8737	Chemical	Gene	resistance|compound|START_ENTITY END_ENTITY|nmod|resistance	Retaining MKP1 expression and attenuating JNK-mediated apoptosis by RIP1 for cisplatin resistance through miR-940 inhibition .
18494946	0	cisplatin	84,93	RRM1	19,23	cisplatin	RRM1	MESH:D002945	6240	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|expression expression|nmod|END_ENTITY	mRNA expression of RRM1 , ERCC1 and ERCC2 is not associated with chemosensitivity to cisplatin , carboplatin and gemcitabine in human lung_cancer cell lines .
12775020	0	cisplatin	39,48	S-1	21,24	cisplatin	S-1	MESH:D002945	5707	Chemical	Gene	combined|nmod|START_ENTITY combined|nsubj|efficacy efficacy|nmod|END_ENTITY	Clinical efficacy of S-1 combined with cisplatin for advanced gastric_cancer .
14556924	0	cisplatin	44,53	S-1	19,22	cisplatin	S-1	MESH:D002945	5707	Chemical	Gene	combined|nmod|START_ENTITY combined|nsubj|study study|nmod|END_ENTITY	A phase I study of S-1 combined with weekly cisplatin for metastatic gastric_cancer in an outpatient setting .
16136370	0	cisplatin	72,81	S-1	37,40	cisplatin	S-1	MESH:D002945	5707	Chemical	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	Performance of outpatient regimen of S-1 in combination with fractional cisplatin for advanced or recurrent gastric_cancers : a phase I study .
16903943	0	cisplatin	75,84	S-1	71,74	cisplatin	S-1	MESH:D002945	5707	Chemical	Gene	chemotherapy|compound|START_ENTITY chemotherapy|compound|END_ENTITY	Complete response of a recurrent advanced urachal_carcinoma treated by S-1 / cisplatin combination chemotherapy .
16953072	0	cisplatin	100,109	S-1	96,99	cisplatin	S-1	MESH:D002945	5707	Chemical	Gene	therapy|compound|START_ENTITY therapy|compound|END_ENTITY	A case of early relapsed multiple lung metastases after esophagectomy successfully treated with S-1 / cisplatin therapy after docetaxel/5-fluorouracil/cisplatin therapy .
17876146	0	cisplatin	77,86	S-1	59,62	cisplatin	S-1	MESH:D002945	5707	Chemical	Gene	responding|advcl|START_ENTITY responding|nmod|END_ENTITY	-LSB- A patient with esophageal_cancer recurrence responding to S-1 combined with cisplatin -LRB- CDDP -RRB- -RSB- .
17876152	0	cisplatin	99,108	S-1	95,98	cisplatin	S-1	MESH:D002945	5707	Chemical	Gene	combination|compound|START_ENTITY combination|dep|-LSB- -LSB-|advcl|responding responding|nmod|END_ENTITY	-LSB- A case of recurrence after resection of stage IV advanced bile_duct_cancer responding well to S-1 / cisplatin combination chemotherapy -RSB- .
18265655	0	cisplatin	9,18	S-1	0,3	cisplatin	S-1	MESH:D002945	5707	Chemical	Gene	therapy|amod|START_ENTITY END_ENTITY|dep|therapy	S-1 plus cisplatin combination therapy for the patients with primary liver_carcinomas .
18628737	0	cisplatin	19,28	S-1	48,51	cisplatin	S-1	MESH:D002945	5707	Chemical	Gene	addition|nmod|START_ENTITY better|nsubj|addition better|nmod|END_ENTITY	Is the addition of cisplatin to S-1 better than S-1 alone for patients with advanced gastroesophageal_cancer ?
18636184	0	cisplatin	94,103	S-1	69,72	cisplatin	S-1	MESH:D002945	5707	Chemical	Gene	infusion|nmod|START_ENTITY infusion|amod|END_ENTITY	Pathological complete response induced by the combination therapy of S-1 and 24-h infusion of cisplatin in two cases initially diagnosed as inoperable advanced gastric_cancer .
18751421	0	cisplatin	49,58	S-1	22,25	cisplatin	S-1	MESH:D002945	5707	Chemical	Gene	combined|nmod|START_ENTITY combined|nsubj|trial trial|nmod|END_ENTITY	Phase 2 trial of oral S-1 combined with low-dose cisplatin for unresectable advanced pancreatic_cancer .
19318372	0	cisplatin	125,134	S-1	12,15	cisplatin	S-1	MESH:D002945	5707	Chemical	Gene	+|dobj|START_ENTITY +|nsubj|Activity Activity|nmod|END_ENTITY	Activity of S-1 in advanced or recurrent gastric_cancer patients after failure of prior chemotherapy , including irinotecan + cisplatin or fluorouracil -LRB- except S-1 -RRB- .
19318372	0	cisplatin	125,134	S-1	159,162	cisplatin	S-1	MESH:D002945	5707	Chemical	Gene	+|dobj|START_ENTITY +|dep|END_ENTITY	Activity of S-1 in advanced or recurrent gastric_cancer patients after failure of prior chemotherapy , including irinotecan + cisplatin or fluorouracil -LRB- except S-1 -RRB- .
20154479	0	cisplatin	49,58	S-1	24,27	cisplatin	S-1	MESH:D002945	5707	Chemical	Gene	infusion|nmod|START_ENTITY infusion|amod|END_ENTITY	-LSB- Combination therapy of S-1 and 24-h infusion of cisplatin after palliative gastrectomy for stage_IV_gastric_cancer -RSB- .
20734110	0	cisplatin	63,72	S-1	17,20	cisplatin	S-1	MESH:D002945	5707	Chemical	Gene	cisplatin|nmod|START_ENTITY cisplatin|compound|END_ENTITY	A pilot study of S-1 plus cisplatin versus 5-fluorouracil plus cisplatin for postoperative chemotherapy in histological stage IIIB-IV -LRB- M0 -RRB- gastric_cancer .
21084805	0	cisplatin	108,117	S-1	90,93	cisplatin	S-1	MESH:D002945	5707	Chemical	Gene	combined|nmod|START_ENTITY END_ENTITY|acl|combined	-LSB- Clinical characteristics of cases showing complete regression of the primary_tumor after S-1 combined with cisplatin administered as neoadjuvant chemotherapy in advanced gastric_carcinoma -RSB- .
21224605	0	cisplatin	82,91	S-1	42,45	cisplatin	S-1	MESH:D002945	5707	Chemical	Gene	-RSB-|compound|START_ENTITY place|nmod|-RSB- docetaxel|nmod|place treated|advcl|docetaxel treated|nmod|END_ENTITY	-LSB- Three cases of gastric_cancer treated by S-1 combined with docetaxel in place of cisplatin -RSB- .
21430401	0	cisplatin	36,45	S-1	18,21	cisplatin	S-1	MESH:D002945	5707	Chemical	Gene	II|dep|START_ENTITY II|dep|trial trial|nmod|END_ENTITY	Phase II trial of S-1 plus low-dose cisplatin for unresectable and recurrent gastric_cancer -LRB- JFMC27-9902 Step2 -RRB- .
21677485	0	cisplatin	34,43	S-1	25,28	cisplatin	S-1	MESH:D002945	5707	Chemical	Gene	combination|compound|START_ENTITY combination|compound|END_ENTITY	Efficacy and toxicity of S-1 plus cisplatin combination neoadjuvant chemotherapy in patients with oral_cancer .
22020563	0	cisplatin	66,75	S-1	37,40	cisplatin	S-1	MESH:D002945	5707	Chemical	Gene	therapy|compound|START_ENTITY Comparison|nmod|therapy Comparison|nmod|monotherapy monotherapy|compound|END_ENTITY	Comparison of safety and efficacy of S-1 monotherapy and S-1 plus cisplatin therapy in elderly patients with advanced gastric_cancer .
22162925	0	cisplatin	128,137	S-1	28,31	cisplatin	S-1	MESH:D002945	5707	Chemical	Gene	given|nmod|START_ENTITY approved|advcl|given approved|nsubj|Tegafur/gimeracil/oteracil Tegafur/gimeracil/oteracil|appos|END_ENTITY	Tegafur/gimeracil/oteracil -LRB- S-1 -RRB- approved for the treatment of advanced gastric_cancer in adults when given in combination with cisplatin : a review comparing it with other fluoropyrimidine-based therapies .
22251551	0	cisplatin	183,192	S-1	138,141	cisplatin	S-1	MESH:D002945	5707	Chemical	Gene	gastrectomy|nmod|START_ENTITY gastrectomy|dobj|treatment treatment|compound|END_ENTITY	Pathological complete response of synchronous multiple liver metastases associated with advanced gastric_cancer to gastrectomy and prompt S-1 treatment in combination with fractional cisplatin : report of a case .
22311679	0	cisplatin	60,69	S-1	52,55	cisplatin	S-1	MESH:D002945	5707	Chemical	Gene	START_ENTITY|nsubj|study study|nmod|chemotherapy chemotherapy|nmod|+ +|compound|END_ENTITY	A feasibility study of outpatient chemotherapy with S-1 + cisplatin in patients with advanced gastric_cancer .
22552360	0	cisplatin	39,48	S-1	30,33	cisplatin	S-1	MESH:D002945	5707	Chemical	Gene	cisplatin|compound|START_ENTITY comparison|nmod|cisplatin comparison|nmod|END_ENTITY	A retrospective comparison of S-1 plus cisplatin and capecitabine plus cisplatin for patients with advanced or recurrent gastric_cancer .
22552360	0	cisplatin	71,80	S-1	30,33	cisplatin	S-1	MESH:D002945	5707	Chemical	Gene	comparison|nmod|START_ENTITY comparison|nmod|END_ENTITY	A retrospective comparison of S-1 plus cisplatin and capecitabine plus cisplatin for patients with advanced or recurrent gastric_cancer .
22593458	0	cisplatin	83,92	S-1	74,77	cisplatin	S-1	MESH:D002945	5707	Chemical	Gene	treatment|compound|START_ENTITY treatment|compound|END_ENTITY	The relationship between antitumor effects and relative dose intensity of S-1 plus cisplatin treatment for metastatic_gastric_cancer .
22783441	0	cisplatin	53,62	S-1	29,32	cisplatin	S-1	MESH:D002945	5707	Chemical	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	Phase II study of palliative S-1 in combination with cisplatin as second-line chemotherapy for gemcitabine-refractory pancreatic cancer patients .
22790052	0	cisplatin	245,254	S-1	154,157	cisplatin	S-1	MESH:D002945	5707	Chemical	Gene	followed|nmod|START_ENTITY followed|csubj|-LSB- -LSB-|nmod|dissemination dissemination|acl:relcl|achieved achieved|nmod|treatments treatments|nmod|END_ENTITY	-LSB- A case of gastric_cancer with peritoneal dissemination who achieved long survival from control of ascites for over 2 years by successive treatments with S-1 in combination with docetaxel as first-line followed by irinotecan in combination with cisplatin as second-line -RSB- .
23848024	0	cisplatin	114,123	S-1	67,70	cisplatin	S-1	MESH:D002945	5707	Chemical	Gene	capecitabine|amod|START_ENTITY treated|nmod|capecitabine therapy|acl|treated therapy|compound|END_ENTITY	-LSB- A case of mediastinal lymph node gastric_cancer recurrence during S-1 adjuvant therapy successfully treated with cisplatin + capecitabine as second-line chemotherapy -RSB- .
23868010	0	cisplatin	64,73	S-1	127,130	cisplatin	S-1	MESH:D002945	5707	Chemical	Gene	chemotherapy|nmod|START_ENTITY trial|nmod|chemotherapy followed|nsubj|trial followed|nmod|administration administration|nmod|chemotherapy chemotherapy|compound|END_ENTITY	Feasibility trial for adjuvant chemotherapy with docetaxel plus cisplatin followed by single agent long-term administration of S-1 chemotherapy in patients with completely resected non-small_cell_lung_cancer : Thoracic Oncology Research Group Study 0809 .
23868010	1	cisplatin	380,389	S-1	338,341	cisplatin	S-1	MESH:D002945	5707	Chemical	Gene	conducted|advcl|START_ENTITY conducted|nmod|chemotherapy chemotherapy|compound|END_ENTITY	BACKGROUND : We conducted a multicentre feasibility study for single agent long-term S-1 chemotherapy following docetaxel plus cisplatin in patients with curatively resected stage II-IIIA non-small_cell_lung_cancer .
23975509	0	cisplatin	20,29	S-1	31,34	cisplatin	S-1	MESH:D002945	5707	Chemical	Gene	study|nmod|START_ENTITY study|dep|END_ENTITY	A phase II study of cisplatin / S-1 in patients with carcinomas of unknown primary site .
23998404	0	cisplatin	49,58	S-1	45,48	cisplatin	S-1	MESH:D002945	5707	Chemical	Gene	chemoradiotherapy|dep|START_ENTITY chemoradiotherapy|nmod|END_ENTITY	Preoperative concurrent chemoradiotherapy of S-1 / cisplatin for stage_III_non-small_cell_lung_cancer .
24045669	0	cisplatin	33,42	S-1	29,32	cisplatin	S-1	MESH:D002945	5707	Chemical	Gene	study|dep|START_ENTITY study|nmod|END_ENTITY	Randomised phase II study of S-1 / cisplatin plus TSU-68 vs S-1 / cisplatin in patients with advanced gastric_cancer .
24045669	0	cisplatin	62,71	S-1	29,32	cisplatin	S-1	MESH:D002945	5707	Chemical	Gene	START_ENTITY|nsubj|study study|nmod|END_ENTITY	Randomised phase II study of S-1 / cisplatin plus TSU-68 vs S-1 / cisplatin in patients with advanced gastric_cancer .
24129809	0	cisplatin	17,26	S-1	30,33	cisplatin	S-1	MESH:D002945	5707	Chemical	Gene	adding|dobj|START_ENTITY adding|nmod|END_ENTITY	Impact of adding cisplatin to S-1 in elderly patients with advanced gastric_cancer .
24218279	0	cisplatin	21,30	S-1	12,15	cisplatin	S-1	MESH:D002945	5707	Chemical	Gene	chemotherapy|compound|START_ENTITY END_ENTITY|nmod|chemotherapy	Efficacy of S-1 plus cisplatin combination chemotherapy in patients with HER2-positive advanced gastric_cancer .
24394071	0	cisplatin	142,151	S-1	138,141	cisplatin	S-1	MESH:D002945	5707	Chemical	Gene	START_ENTITY|dep|-LSB- -LSB-|dobj|case case|acl:relcl|obtained obtained|nmod|END_ENTITY	-LSB- A case of locally advanced gastric_cancer in which pathological complete response -LRB- PCR -RRB- was obtained after combination chemotherapy with S-1 / cisplatin -RSB- .
25572571	0	cisplatin	55,64	S-1	0,3	cisplatin	S-1	MESH:D002945	5707	Chemical	Gene	radiotherapy|nmod|START_ENTITY END_ENTITY|nmod|radiotherapy	S-1 plus cisplatin with concurrent radiotherapy versus cisplatin alone with concurrent radiotherapy for stage_III_non-small_cell_lung_cancer : a pilot randomized controlled trial .
25797356	0	cisplatin	58,67	S-1	147,150	cisplatin	S-1	MESH:D002945	5707	Chemical	Gene	trial|nmod|START_ENTITY trial|nmod|refractory refractory|nmod|monotherapy monotherapy|compound|END_ENTITY	Randomised phase III trial of second-line irinotecan plus cisplatin versus irinotecan alone in patients with advanced gastric_cancer refractory to S-1 monotherapy : TRICS trial .
25933246	0	cisplatin	18,27	S-1	0,3	cisplatin	S-1	MESH:D002945	5707	Chemical	Gene	combined|nmod|START_ENTITY END_ENTITY|acl|combined	S-1 combined with cisplatin versus cisplatin alone for the treatment of advanced gastric_cancer : a pilot randomized-controlled trial .
25933246	0	cisplatin	35,44	S-1	0,3	cisplatin	S-1	MESH:D002945	5707	Chemical	Gene	cisplatin|nmod|START_ENTITY combined|nmod|cisplatin END_ENTITY|acl|combined	S-1 combined with cisplatin versus cisplatin alone for the treatment of advanced gastric_cancer : a pilot randomized-controlled trial .
26304854	0	cisplatin	84,93	S-1	29,32	cisplatin	S-1	MESH:D002945	5707	Chemical	Gene	radiotherapy|nmod|START_ENTITY radiotherapy|nmod|END_ENTITY	Concurrent radiotherapy with S-1 plus cisplatin versus concurrent radiotherapy with cisplatin alone for the treatment of locally advanced_cervical_carcinoma : a pilot randomised controlled trial .
26304854	0	cisplatin	84,93	S-1	29,32	cisplatin	S-1	MESH:D002945	5707	Chemical	Gene	radiotherapy|nmod|START_ENTITY radiotherapy|nmod|END_ENTITY	Concurrent radiotherapy with S-1 plus cisplatin versus concurrent radiotherapy with cisplatin alone for the treatment of locally advanced_cervical_carcinoma : a pilot randomised controlled trial .
26439700	0	cisplatin	44,53	S-1	0,3	cisplatin	S-1	MESH:D002945	5707	Chemical	Gene	cisplatin|nmod|START_ENTITY cisplatin|compound|END_ENTITY	S-1 plus cisplatin versus fluorouracil plus cisplatin in advanced gastric or gastro-esophageal junction adenocarcinoma patients : a pilot study .
26846507	0	cisplatin	33,42	S-1	29,32	cisplatin	S-1	MESH:D002945	5707	Chemical	Gene	followed|nsubj|START_ENTITY study|parataxis|followed study|nmod|END_ENTITY	A phase II study of adjuvant S-1 / cisplatin chemotherapy followed by S-1-based chemoradiotherapy for D2-resected gastric_cancer .
27014419	0	cisplatin	145,154	S-1	136,139	cisplatin	S-1	MESH:D002945	5707	Chemical	Gene	chemotherapy|compound|START_ENTITY END_ENTITY|nmod|chemotherapy	Prognostic impact of KRAS mutant type and MET amplification in metastatic and recurrent gastric_cancer patients treated with first-line S-1 plus cisplatin chemotherapy .
19909727	0	cisplatin	41,50	SHP2	24,28	cisplatin	SHP2	MESH:D002945	5781	Chemical	Gene	activity|nmod|START_ENTITY activity|nummod|END_ENTITY	Selective activation of SHP2 activity by cisplatin revealed by a novel chemical probe-based assay .
18723829	0	cisplatin	29,38	SIRT1	0,5	cisplatin	SIRT1	MESH:D002945	23411	Chemical	Gene	contributes|xcomp|START_ENTITY contributes|nsubj|END_ENTITY	SIRT1 contributes in part to cisplatin resistance in cancer cells by altering mitochondrial metabolism .
22330808	5	cisplatin	997,1006	SIRT1	906,911	cisplatin	SIRT1	MESH:D002945	23411	Chemical	Gene	exposed|nmod|START_ENTITY exposed|nmod|overexpression overexpression|nummod|END_ENTITY	To investigate the effect of SIRT1 in on cisplatin-induced acetylation of p65 subunit of NF-kB and cell injury , HK2 cells were exposed with SIRT1 overexpression , LacZ adenovirus or dominant negative adenovirus after treatment with cisplatin .
24240701	0	cisplatin	84,93	SIRT1	0,5	cisplatin	SIRT1	MESH:D002945	23411	Chemical	Gene	mediate|nmod|START_ENTITY mediate|nsubj|END_ENTITY	SIRT1 and AMPK mediate hypoxia-induced resistance of non-small_cell_lung_cancers to cisplatin and doxorubicin .
25973238	0	cisplatin	93,102	SIRT1	21,26	cisplatin	SIRT1	MESH:D002945	23411	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|expression expression|nmod|END_ENTITY	Higher expression of SIRT1 induced resistance of esophageal_squamous_cell_carcinoma cells to cisplatin .
20672702	0	cisplatin	40,49	SPCA-1	53,59	cisplatin	SPCA-1	MESH:D002945	27032	Chemical	Gene	START_ENTITY|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- The role of GRP78 on the resistance to cisplatin in SPCA-1 cell line -RSB- .
25866223	0	cisplatin	24,33	SRPK1	15,20	cisplatin	SRPK1	MESH:D002945	6732	Chemical	Gene	resistance|compound|START_ENTITY END_ENTITY|nmod|resistance	Involvement of SRPK1 in cisplatin resistance related to long non-coding RNA UCA1 in human ovarian_cancer cells .
25967360	0	cisplatin	24,33	SRPK1	15,20	cisplatin	SRPK1	MESH:D002945	6732	Chemical	Gene	resistance|compound|START_ENTITY END_ENTITY|nmod|resistance	Involvement of SRPK1 in cisplatin resistance related to long non-coding RNA UCA1 in human ovarian_cancer cells .
21608020	0	cisplatin	56,65	STAT3	92,97	cisplatin	STAT3	MESH:D002945	6774	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Arctigenin enhances chemosensitivity of cancer cells to cisplatin through inhibition of the STAT3 signaling pathway .
21489989	6	cisplatin	1019,1028	STK17B	996,1002	cisplatin	STK17A	MESH:D002945	9263	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	STK17A is not present in the mouse genome , but the closely related gene STK17B is induced with cisplatin in mouse NIH3T3 cells , although this induction is p53-independent .
24763424	0	cisplatin	72,81	Sky1	0,4	cisplatin	Sky1	MESH:D002945	855256(Tax:4932)	Chemical	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Sky1 regulates the expression of sulfur metabolism genes in response to cisplatin .
18822208	0	cisplatin	51,60	Smac	27,31	cisplatin	Smac	MESH:D002945	56616	Chemical	Gene	coupling|nmod|START_ENTITY coupling|amod|END_ENTITY	-LSB- Effects of over-expressed Smac gene coupling with cisplatin on proliferation and apoptosis of hepatocarcinoma cells -RSB- .
19500507	0	cisplatin	102,111	Smac	69,73	cisplatin	Smac	MESH:D002945	56616	Chemical	Gene	-RSB-|compound|START_ENTITY sensitizing|nmod|-RSB- Bx-PC3|xcomp|sensitizing Bx-PC3|nmod|END_ENTITY	-LSB- Interference of survivin in pancreatic_cancer Bx-PC3 cell line with Smac sensitizing its response to cisplatin -RSB- .
22482401	0	cisplatin	108,117	Smac	19,23	cisplatin	Smac	MESH:D002945	56616	Chemical	Gene	-RSB-|compound|START_ENTITY enhanced|nmod|-RSB- enhanced|nsubj|Overexpression Overexpression|nmod|gene gene|amod|END_ENTITY	-LSB- Overexpression of Smac gene enhanced chemotherapeutic sensitivity of esophageal_cancer cell line Eca109 to cisplatin -RSB- .
26770460	0	cisplatin	35,44	Smac	10,14	cisplatin	Smac	MESH:D002945	56616	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of Smac in combination with cisplatin on esophageal_cancer cell line ECA109 .
25260657	0	cisplatin	21,30	TCRP1	0,5	cisplatin	TCRP1	MESH:D002945	23201	Chemical	Gene	contributes|xcomp|START_ENTITY contributes|nsubj|END_ENTITY	TCRP1 contributes to cisplatin resistance by preventing Pol_b degradation in lung_cancer cells .
17577631	0	cisplatin	55,64	TRAIL	103,108	cisplatin	TRAIL	MESH:D002945	8743	Chemical	Gene	combining|dobj|START_ENTITY death|acl|combining induction|nmod|death adenovirus|nsubj|induction adenovirus|xcomp|carrying carrying|dobj|END_ENTITY	Synergistic induction of tumor cell death by combining cisplatin with an oncolytic adenovirus carrying TRAIL .
21291526	0	cisplatin	76,85	TRAIL	45,50	cisplatin	TRAIL	MESH:D002945	8743	Chemical	Gene	combined|nmod|START_ENTITY combined|nsubj|effect effect|nmod|expression expression|amod|END_ENTITY	Synergistic antitumor effect of AAV-mediated TRAIL expression combined with cisplatin on head and neck_squamous_cell_carcinoma .
22922789	0	cisplatin	98,107	TRAIL	41,46	cisplatin	TRAIL	MESH:D002945	8743	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The inhibitory effect of MSCs expressing TRAIL as a cellular delivery vehicle in combination with cisplatin on hepatocellular_carcinoma .
26463141	0	cisplatin	24,33	TRAIL	60,65	cisplatin	TRAIL	MESH:D002945	8743	Chemical	Gene	START_ENTITY|acl|enhance enhance|dobj|ability ability|nmod|END_ENTITY	-LSB- Molecular mechanism of cisplatin to enhance the ability of TRAIL in reversing multidrug resistance in gastric_cancer cells -RSB- .
15942793	0	cisplatin	22,31	TauT	14,18	cisplatin	TauT	MESH:D002945	106504129	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of TauT by cisplatin in LLC-PK1 renal cells .
19763620	0	cisplatin	24,33	Transglutaminase_2	0,18	cisplatin	Transglutaminase 2	MESH:D002945	7052	Chemical	Gene	resistance|compound|START_ENTITY END_ENTITY|nmod|resistance	Transglutaminase_2 as a cisplatin resistance marker in non-small_cell_lung_cancer .
22673193	0	cisplatin	46,55	Twist1	13,19	cisplatin	Twist1	MESH:D002945	7291	Chemical	Gene	sensitizes|xcomp|START_ENTITY sensitizes|nsubj|Silencing Silencing|nmod|END_ENTITY	Silencing of Twist1 sensitizes NSCLC cells to cisplatin via AMPK-activated mTOR inhibition .
25867064	0	cisplatin	63,72	Twist1	22,28	cisplatin	Twist1	MESH:D002945	7291	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	miR-186 regulation of Twist1 and ovarian_cancer sensitivity to cisplatin .
10885607	0	cisplatin	45,54	VP16	75,79	cisplatin	VP16	MESH:D002945	3054	Chemical	Gene	START_ENTITY|dep|regimen regimen|appos|END_ENTITY	Up-front chemotherapy with fotemustine -LRB- F -RRB- / cisplatin -LRB- CDDP -RRB- / etoposide -LRB- VP16 -RRB- regimen in the treatment of 33 non-removable glioblastomas .
25809464	0	cisplatin	28,37	X-linked_inhibitor_of_apoptosis_protein	63,102	cisplatin	X-linked inhibitor of apoptosis protein	MESH:D002945	11798(Tax:10090)	Chemical	Gene	protection|nmod|START_ENTITY protection|nmod|transfection transfection|nmod|END_ENTITY	Cochlear protection against cisplatin by viral transfection of X-linked_inhibitor_of_apoptosis_protein across round window membrane .
8797596	0	cisplatin	96,105	YB-1	40,44	cisplatin	YB-1	MESH:D002945	4904	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of the human Y_box-binding_protein YB-1 in cellular sensitivity to the DNA-damaging agents cisplatin , mitomycin_C , and ultraviolet light .
20440617	0	cisplatin	38,47	aminopeptidase_N	86,102	cisplatin	aminopeptidase N	MESH:D002945	290	Chemical	Gene	nephroprotection|compound|START_ENTITY study|nmod|nephroprotection study|dep|modulation modulation|nmod|END_ENTITY	Mechanistic study of BNP7787-mediated cisplatin nephroprotection : modulation of human aminopeptidase_N .
2451473	0	cisplatin	43,52	angiotensin-II	88,102	cisplatin	angiotensin-II	MESH:D002945	183	Chemical	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	-LSB- Hepatic artery infusion chemotherapy with cisplatin and adriamycin in combination with angiotensin-II in the treatment of malignant liver_tumors -RSB- .
2752512	0	cisplatin	64,73	aprt	85,89	cisplatin	aprt	MESH:D002945	100765665	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Sequence specificity of mutation induced by the anti-tumor drug cisplatin in the CHO aprt gene .
25310746	0	cisplatin	59,68	bcl-xL	95,101	cisplatin	bcl-xL	MESH:D002945	598	Chemical	Gene	START_ENTITY|nmod|downregulation downregulation|nmod|END_ENTITY	The alkaloid emetine sensitizes ovarian_carcinoma cells to cisplatin through downregulation of bcl-xL .
3063983	0	cisplatin	60,69	beta_2-microglobulin	6,26	cisplatin	beta 2-microglobulin	MESH:D002945	567	Chemical	Gene	administration|nmod|START_ENTITY END_ENTITY|nmod|administration	Serum beta_2-microglobulin after five-day administration of cisplatin .
21038681	0	cisplatin	11,20	caspase-3	76,85	cisplatin	caspase-3	MESH:D002945	12367(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Effect of cisplatin on apoptosis of spiral_ganglion cell and expression of caspase-3 in mouse cochlea -RSB- .
14969818	0	cisplatin	22,31	caspase-activated_deoxyribonuclease	54,89	cisplatin	caspase-activated deoxyribonuclease	MESH:D002945	13368(Tax:10090)	Chemical	Gene	treatment|nmod|START_ENTITY treatment|nmod|END_ENTITY	Combined treatment of cisplatin and overexpression of caspase-activated_deoxyribonuclease -LRB- CAD -RRB- promotes apoptosis in vitro and in vivo .
17699106	0	cisplatin	54,63	ceramide_synthase_1	9,28	cisplatin	ceramide synthase 1	MESH:D002945	10715	Chemical	Gene	regulated|nmod|START_ENTITY END_ENTITY|acl|regulated	-LRB- Dihydro -RRB- ceramide_synthase_1 regulated sensitivity to cisplatin is associated with the activation of p38_mitogen-activated_protein_kinase and is abrogated by sphingosine kinase 1 .
14732223	0	cisplatin	53,62	clusterin	81,90	cisplatin	clusterin	MESH:D002945	1191	Chemical	Gene	START_ENTITY|nmod|suppression suppression|nmod|END_ENTITY	Enhanced chemosensitivity of bladder_cancer cells to cisplatin by suppression of clusterin in vitro .
25960233	0	cisplatin	60,69	contactin-1	100,111	cisplatin	contactin-1	MESH:D002945	1272	Chemical	Gene	START_ENTITY|acl|associated associated|nmod|END_ENTITY	Increased sensitivity of human lung_adenocarcinoma cells to cisplatin associated with downregulated contactin-1 .
23010323	0	cisplatin	38,47	copper_transporter_1	13,33	cisplatin	copper transporter 1	MESH:D002945	1317	Chemical	Gene	resistance|compound|START_ENTITY END_ENTITY|nmod|resistance	Relevance of copper_transporter_1 for cisplatin resistance in human ovarian_carcinoma cells .
11404608	0	cisplatin	74,83	cyclin_D1	10,19	cisplatin	cyclin D1	MESH:D002945	12443(Tax:10090)	Chemical	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	Antisense cyclin_D1 enhances sensitivity of head_and_neck_cancer cells to cisplatin .
15371874	0	cisplatin	48,57	cyclooxygenase-2	132,148	cisplatin	cyclooxygenase-2	MESH:D002945	5743	Chemical	Gene	cells|nmod|START_ENTITY sensitivity|nmod|cells mediated|nsubj|sensitivity mediated|nmod|JTE-522 JTE-522|amod|END_ENTITY	Enhanced sensitivity of bladder_cancer cells to cisplatin mediated cytotoxicity and apoptosis in vitro and in vivo by the selective cyclooxygenase-2 inhibitor JTE-522 .
16273249	0	cisplatin	30,39	cyclooxygenase-2	43,59	cisplatin	cyclooxygenase-2	MESH:D002945	5743	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|amod|END_ENTITY	Inhibition of cytotoxicity of cisplatin by cyclooxygenase-2 inhibitor nimesulide in head_and_neck_cancer cell lines .
21205525	0	cisplatin	82,91	cyclooxygenase-2	12,28	cisplatin	cyclooxygenase-2	MESH:D002945	5743	Chemical	Gene	proliferation|nmod|START_ENTITY vector|nmod|proliferation vector|amod|END_ENTITY	-LSB- Effects of cyclooxygenase-2 antisense vector on proliferation and sensitivity to cisplatin of H1299 cells -RSB- .
21232215	0	cisplatin	65,74	cyclooxygenase-2	11,27	cisplatin	cyclooxygenase-2	MESH:D002945	5743	Chemical	Gene	combined|nmod|START_ENTITY combined|nsubj|Effect Effect|nmod|inhibitor inhibitor|amod|END_ENTITY	-LSB- Effect of cyclooxygenase-2 inhibitor , nimesulide , combined with cisplatin on lung_cancer -RSB- .
25109742	0	cisplatin	40,49	cyclooxygenase-2	110,126	cisplatin	cyclooxygenase-2	MESH:D002945	5743	Chemical	Gene	sensitivity|compound|START_ENTITY enhances|dobj|sensitivity enhances|advcl|modulating modulating|dobj|pathway pathway|amod|END_ENTITY	Enforced expression of miR-101 enhances cisplatin sensitivity in human bladder_cancer cells by modulating the cyclooxygenase-2 pathway .
26407653	0	cisplatin	43,52	cyclooxygenase-2	115,131	cisplatin	cyclooxygenase-2	MESH:D002945	5743	Chemical	Gene	effect|nmod|START_ENTITY enhanced|dobj|effect enhanced|nmod|inhibition inhibition|nmod|END_ENTITY	Celecoxib enhanced the cytotoxic effect of cisplatin in drug-resistant human gastric_cancer cells by inhibition of cyclooxygenase-2 .
1427396	0	cisplatin	69,78	cyclosporin_A	15,28	cisplatin	cyclosporin A	MESH:D002945	1161	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of cyclosporin_A on the lysis of ovarian_cancer cells by cisplatin or adriamycin .
26321522	0	cisplatin	63,72	endostatin	38,48	cisplatin	endostatin	MESH:D002945	80781	Chemical	Gene	combined|nmod|START_ENTITY combined|nsubj|effect effect|nmod|END_ENTITY	Antitumor effect of recombinant human endostatin combined with cisplatin on rats with transplanted Lewis_lung_cancer .
10601618	0	cisplatin	108,117	epidermal_growth_factor	46,69	cisplatin	epidermal growth factor	MESH:D002945	1950	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Concordance between tumour cell activation by epidermal_growth_factor and alteration of cell sensitivity to cisplatin and lymphokine-activated killer cell activity .
19220256	0	cisplatin	148,157	epidermal_growth_factor_receptor	5,37	cisplatin	epidermal growth factor receptor	MESH:D002945	1956	Chemical	Gene	sensitizes|xcomp|START_ENTITY sensitizes|nsubj|END_ENTITY	Dual epidermal_growth_factor_receptor and vascular endothelial growth factor receptor inhibition with vandetanib sensitizes bladder_cancer cells to cisplatin in a dose - and sequence-dependent manner .
10329047	0	cisplatin	71,80	erythropoietin	29,43	cisplatin	erythropoietin	MESH:D002945	2056	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nmod|effect	Effects of recombinant human erythropoietin on the antitumor effect of cisplatin in SCID mice bearing human ovarian_cancer : A possible oxygen effect .
1574960	0	cisplatin	93,102	erythropoietin	18,32	cisplatin	erythropoietin	MESH:D002945	2056	Chemical	Gene	chemotherapy|compound|START_ENTITY secondary|nmod|chemotherapy ovarian_carcinoma|amod|secondary patients|nmod|ovarian_carcinoma END_ENTITY|nmod|patients	Recombinant human erythropoietin in patients with ovarian_carcinoma and anaemia secondary to cisplatin and carboplatin chemotherapy : preliminary results .
1634143	0	cisplatin	66,75	erythropoietin	6,20	cisplatin	erythropoietin	MESH:D002945	2056	Chemical	Gene	chemotherapy|amod|START_ENTITY levels|nmod|chemotherapy levels|compound|END_ENTITY	Serum erythropoietin levels in gynecologic_cancer patients during cisplatin combination chemotherapy .
17922127	0	cisplatin	106,115	erythropoietin	12,26	cisplatin	erythropoietin	MESH:D002945	2056	Chemical	Gene	affects|nmod|START_ENTITY affects|nsubj|END_ENTITY	Recombinant erythropoietin differently affects proliferation of mesothelioma cells but not sensitivity to cisplatin and pemetrexed .
20722073	0	cisplatin	39,48	erythropoietin	21,35	cisplatin	erythropoietin	MESH:D002945	24335(Tax:10116)	Chemical	Gene	neurotoxicity|amod|START_ENTITY END_ENTITY|nmod|neurotoxicity	Different effects of erythropoietin in cisplatin - and docetaxel-induced neurotoxicity : an in vitro study .
21920723	0	cisplatin	55,64	erythropoietin	10,24	cisplatin	erythropoietin	MESH:D002945	24335(Tax:10116)	Chemical	Gene	progression|nmod|START_ENTITY therapy|nmod|progression therapy|compound|END_ENTITY	Effect of erythropoietin therapy on the progression of cisplatin induced renal_injury in rats .
22664391	0	cisplatin	74,83	erythropoietin	149,163	cisplatin	erythropoietin	MESH:D002945	2056	Chemical	Gene	Induction|nmod|START_ENTITY Induction|dep|effect effect|nmod|END_ENTITY	Induction of DNA fragmentation , chromosome aberrations and micronuclei by cisplatin in rat bone-marrow cells : protective effect of recombinant human erythropoietin .
23077460	0	cisplatin	89,98	erythropoietin	40,54	cisplatin	erythropoietin	MESH:D002945	2056	Chemical	Gene	response|nmod|START_ENTITY effect|nmod|response effect|nmod|END_ENTITY	Contrasting effect of recombinant human erythropoietin on breast_cancer cell response to cisplatin induced cytotoxicity .
25758589	0	cisplatin	68,77	erythropoietin	47,61	cisplatin	erythropoietin	MESH:D002945	2056	Chemical	Gene	using|dobj|START_ENTITY END_ENTITY|acl|using	Evaluation of multi-neuroprotective effects of erythropoietin using cisplatin induced peripheral_neurotoxicity model .
8887884	0	cisplatin	11,20	erythropoietin	24,38	cisplatin	erythropoietin	MESH:D002945	24335(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|production production|compound|END_ENTITY	Effects of cisplatin on erythropoietin production in rats .
9166485	0	cisplatin	78,87	erythropoietin	18,32	cisplatin	erythropoietin	MESH:D002945	2056	Chemical	Gene	receiving|dobj|START_ENTITY therapy|acl|receiving therapy|compound|END_ENTITY	Recombinant human erythropoietin therapy for anemic_cancer patients receiving cisplatin chemotherapy .
25083297	0	cisplatin	136,145	excision_repair_cross_complement-1	44,78	cisplatin	excision repair cross complement-1	MESH:D002945	2067	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Breast_cancer_resistance_protein -LRB- BCRP -RRB- and excision_repair_cross_complement-1 -LRB- ERCC1 -RRB- expression in esophageal_cancers and response to cisplatin and irinotecan based chemotherapy .
15386344	0	cisplatin	69,78	fas-L	49,54	cisplatin	fas-L	MESH:D002945	356	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Long-term activation of SAPK/JNK , p38 kinase and fas-L expression by cisplatin is attenuated in human carcinoma cells that acquired drug resistance .
12706370	0	cisplatin	76,85	gamma-Glutamyl_transpeptidase	0,29	cisplatin	gamma-Glutamyl transpeptidase	MESH:D002945	92086	Chemical	Gene	detoxification|nmod|START_ENTITY catalyses|dobj|detoxification catalyses|nsubj|END_ENTITY	gamma-Glutamyl_transpeptidase catalyses the extracellular detoxification of cisplatin in a human cell line derived from the proximal convoluted tubule of the kidney .
10487615	0	cisplatin	88,97	gamma-glutamyl_transpeptidase	39,68	cisplatin	gamma-glutamyl transpeptidase	MESH:D002945	92086	Chemical	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Human germ cell tumours : expression of gamma-glutamyl_transpeptidase and sensitivity to cisplatin .
19714332	0	cisplatin	38,47	gamma-glutamyl_transpeptidase	80,109	cisplatin	gamma-glutamyl transpeptidase	MESH:D002945	92086	Chemical	Gene	nephroprotection|compound|START_ENTITY study|nmod|nephroprotection study|dep|modulation modulation|nmod|END_ENTITY	Mechanistic study of BNP7787-mediated cisplatin nephroprotection : modulation of gamma-glutamyl_transpeptidase .
8765241	0	cisplatin	99,108	gamma-glutamyl_transpeptidase	40,69	cisplatin	gamma-glutamyl transpeptidase	MESH:D002945	116568(Tax:10116)	Chemical	Gene	nephrotoxicity|nmod|START_ENTITY blocks|dobj|nephrotoxicity blocks|nsubj|inhibition inhibition|nmod|END_ENTITY	Cisplatin nephrotoxicity : inhibition of gamma-glutamyl_transpeptidase blocks the nephrotoxicity of cisplatin without reducing platinum concentrations in the kidney .
12123741	0	cisplatin	37,46	gamma-glutamyltransferase	68,93	cisplatin	gamma-glutamyltransferase	MESH:D002945	728226	Chemical	Gene	START_ENTITY|nmod|overexpression overexpression|nmod|END_ENTITY	Enhanced resistance of HeLa cells to cisplatin by overexpression of gamma-glutamyltransferase .
10664037	0	cisplatin	10,19	glutathione-S-transferase	41,66	cisplatin	glutathione-S-transferase	MESH:D002945	58962(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	Effect of cisplatin on the expression of glutathione-S-transferase in the cochlea of the rat .
10465134	0	cisplatin	46,55	granulocyte-colony_stimulating_factor	90,127	cisplatin	granulocyte-colony stimulating factor	MESH:D002945	1440	Chemical	Gene	study|dep|START_ENTITY study|nmod|END_ENTITY	A phase II study of a three-drug combination -LRB- cisplatin , ifosfamide and vinorelbine -RRB- plus granulocyte-colony_stimulating_factor in advanced non_small_cell_lung_cancer .
8774656	0	cisplatin	59,68	granulocyte_colony-stimulating_factor	11,48	cisplatin	granulocyte colony-stimulating factor	MESH:D002945	1440	Chemical	Gene	START_ENTITY|nsubj|increases increases|amod|END_ENTITY	Sequential granulocyte_colony-stimulating_factor increases cisplatin cytotoxicity in human epithelial_ovarian_cancer cell lines .
9073317	0	cisplatin	84,93	granulocyte_colony_stimulating_factor	10,47	cisplatin	granulocyte colony stimulating factor	MESH:D002945	396839(Tax:9823)	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|Effect Effect|nmod|END_ENTITY	Effect of granulocyte_colony_stimulating_factor on pig blood platelets treated with cisplatin in vitro .
18523133	0	cisplatin	61,70	hCtr1	119,124	cisplatin	hCtr1	MESH:D002945	1317	Chemical	Gene	START_ENTITY|nmod|up-regulation up-regulation|nmod|END_ENTITY	Elevated glutathione levels confer cellular sensitization to cisplatin toxicity by up-regulation of copper transporter hCtr1 .
19639202	0	cisplatin	46,55	hTERT	17,22	cisplatin	hTERT	MESH:D002945	7015	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Up-regulation of hTERT expression by low-dose cisplatin contributes to chemotherapy resistance in human hepatocellular_cancer cells .
17390020	0	cisplatin	60,69	histone_deacetylase	73,92	cisplatin	histone deacetylase	MESH:D002945	9734	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|amod|END_ENTITY	Chemosensitization of oral_squamous_cell_carcinoma cells to cisplatin by histone_deacetylase inhibitor , suberoylanilide_hydroxamic_acid .
24355296	0	cisplatin	91,100	histone_deacetylase	2,21	cisplatin	histone deacetylase	MESH:D002945	9734	Chemical	Gene	activity|compound|START_ENTITY enhances|dobj|activity enhances|nsubj|YCW1 YCW1|amod|END_ENTITY	A histone_deacetylase inhibitor YCW1 with antitumor and antimetastasis properties enhances cisplatin activity against non-small_cell_lung_cancer in preclinical studies .
25963435	0	cisplatin	46,55	histone_deacetylase	77,96	cisplatin	histone deacetylase	MESH:D002945	9734	Chemical	Gene	START_ENTITY|nmod|valproate valproate|amod|END_ENTITY	The synergistic effects of DNA-damaging drugs cisplatin and etoposide with a histone_deacetylase inhibitor valproate in high-risk neuroblastoma cells .
9018110	0	cisplatin	50,59	hsp72	28,33	cisplatin	hsp72	MESH:D002945	3303	Chemical	Gene	Suppression|nmod|START_ENTITY Suppression|nmod|accumulation accumulation|amod|END_ENTITY	Suppression of heat-induced hsp72 accumulation by cisplatin in human glioblastoma cells .
10757560	0	cisplatin	117,126	inducible_nitric_oxide_synthase	14,45	cisplatin	inducible nitric oxide synthase	MESH:D002945	100135576(Tax:10141)	Chemical	Gene	application|nmod|START_ENTITY guinea_pigs|nmod|application vestibule|nmod|guinea_pigs Expression|nmod|vestibule Expression|nmod|END_ENTITY	Expression of inducible_nitric_oxide_synthase -LRB- iNOS/NOS II -RRB- in the vestibule of guinea_pigs after the application of cisplatin .
9402312	0	cisplatin	11,20	inducible_nitric_oxide_synthase	34,65	cisplatin	inducible nitric oxide synthase	MESH:D002945	24599(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of cisplatin and taxol on inducible_nitric_oxide_synthase , gastrin and somatostatin in gastrointestinal_toxicity .
24405596	0	cisplatin	75,84	interleukin-24	30,44	cisplatin	interleukin-24	MESH:D002945	11009	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of recombinant human interleukin-24 alone and in combination with cisplatin on the growth of ovarian_cancer cells in vitro -RSB- .
15547764	0	cisplatin	63,72	lung_resistance-related_protein	10,41	cisplatin	lung resistance-related protein	MESH:D002945	9961	Chemical	Gene	resistance|acl|START_ENTITY END_ENTITY|nmod|resistance	Effect of lung_resistance-related_protein on the resistance to cisplatin in human ovarian_cancer cell lines .
22673193	0	cisplatin	46,55	mTOR	75,79	cisplatin	mTOR	MESH:D002945	21977(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|compound|END_ENTITY	Silencing of Twist1 sensitizes NSCLC cells to cisplatin via AMPK-activated mTOR inhibition .
24462866	0	cisplatin	56,65	mTOR	70,74	cisplatin	mTOR	MESH:D002945	21977(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|compound|END_ENTITY	Dihydroartemisinin potentiates the anticancer effect of cisplatin via mTOR inhibition in cisplatin-resistant ovarian_cancer cells : involvement of apoptosis and autophagy .
24568519	0	cisplatin	60,69	mTOR	98,102	cisplatin	mTOR	MESH:D002945	21977(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|direct direct|nmod|END_ENTITY	MicroRNA-100 resensitizes resistant chondrosarcoma cells to cisplatin through direct targeting of mTOR .
19874802	0	cisplatin	11,20	matrix_metalloproteinase-2	24,50	cisplatin	matrix metalloproteinase-2	MESH:D002945	81686(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|cells cells|amod|END_ENTITY	Effects of cisplatin on matrix_metalloproteinase-2 in transformed thyroid cells .
19624892	0	cisplatin	11,20	matrix_metalloproteinase-9	38,64	cisplatin	matrix metalloproteinase-9	MESH:D002945	17395(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Effect of cisplatin on expression of matrix_metalloproteinase-9 and tissue_inhibitor_of_metalloproteinase-1 and their correlations in Lewis lung_cancer in mice -RSB- .
19536566	0	cisplatin	41,50	metallothionein-3	18,35	cisplatin	metallothionein-3	MESH:D002945	4504	Chemical	Gene	Reaction|nmod|START_ENTITY Reaction|nmod|END_ENTITY	Reaction of human metallothionein-3 with cisplatin and transplatin .
25287716	0	cisplatin	18,27	miR-150	0,7	cisplatin	miR-150	MESH:D002945	406942	Chemical	Gene	START_ENTITY|nsubj|modulates modulates|amod|END_ENTITY	miR-150 modulates cisplatin chemosensitivity and invasiveness of muscle-invasive_bladder_cancer cells via targeting PDCD4 in vitro .
26314859	0	cisplatin	43,52	miR-15a	0,7	cisplatin	miR-15a	MESH:D002945	406948	Chemical	Gene	effects|nmod|START_ENTITY enhances|dobj|effects enhances|nsubj|END_ENTITY	miR-15a enhances the anticancer effects of cisplatin in the resistant non-small_cell_lung_cancer cells .
25867064	0	cisplatin	63,72	miR-186	0,7	cisplatin	miR-186	MESH:D002945	406962	Chemical	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	miR-186 regulation of Twist1 and ovarian_cancer sensitivity to cisplatin .
26623722	0	cisplatin	52,61	miR-302b	0,8	cisplatin	miR-302b	MESH:D002945	442894	Chemical	Gene	enhances|xcomp|START_ENTITY enhances|nsubj|END_ENTITY	miR-302b enhances breast_cancer cell sensitivity to cisplatin by regulating E2F1 and the cellular DNA damage response .
24248414	0	cisplatin	57,66	miR-449a	0,8	cisplatin	miR-449a	MESH:D002945	554213	Chemical	Gene	Regulates|advcl|START_ENTITY Regulates|nsubj|END_ENTITY	miR-449a Regulates proliferation and chemosensitivity to cisplatin by targeting cyclin_D1 and BCL2 in SGC7901 cells .
23856992	3	cisplatin	467,476	miR-503	395,402	cisplatin	miR-503	MESH:D002945	574506	Chemical	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	In this study , we report that miR-503 regulates the resistance of non-small_cell_lung_cancer cells to cisplatin .
12168849	0	cisplatin	68,77	multidrug_resistance-associated_protein_2	15,56	cisplatin	multidrug resistance-associated protein 2	MESH:D002945	25303(Tax:10116)	Chemical	Gene	resistance|compound|START_ENTITY END_ENTITY|nmod|resistance	Involvement of multidrug_resistance-associated_protein_2 in in vivo cisplatin resistance of rat hepatoma AH66 cells .
19007063	0	cisplatin	56,65	nm23-H1	69,76	cisplatin	nm23-H1	MESH:D002945	4830	Chemical	Gene	START_ENTITY|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Study of increased sensitivity on Tca8113 cell line to cisplatin by nm23-H1 in vitro -RSB- .
21905038	0	cisplatin	48,57	organic_cation_transporter_3	16,44	cisplatin	organic cation transporter 3	MESH:D002945	100049579	Chemical	Gene	Contribution|acl|START_ENTITY Contribution|nmod|END_ENTITY	Contribution of organic_cation_transporter_3 to cisplatin cytotoxicity in human cervical_cancer cells .
26397192	0	cisplatin	53,62	osteopontin	18,29	cisplatin	osteopontin	MESH:D002945	6696	Chemical	Gene	treatment|compound|START_ENTITY promotes|nmod|treatment promotes|nsubj|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of osteopontin promotes resistance to cisplatin treatment in HCC .
10878562	0	cisplatin	61,70	p31	41,44	cisplatin	p31	MESH:D002945	529	Chemical	Gene	cells|nmod|START_ENTITY cells|amod|END_ENTITY	Response in shape and size of individual p31 cancer cells to cisplatin and ouabain : a computerized image analysis of cell halo characteristics during continuous perfusion .
10569615	0	cisplatin	41,50	p53	114,117	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	START_ENTITY|nmod|overexpression overexpression|nmod|END_ENTITY	Synergistic enhancement of resistance to cisplatin in human bladder_cancer cells by overexpression of mutant-type p53 and Bcl-2 .
10626356	0	cisplatin	93,102	p53	8,11	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	resistance|compound|START_ENTITY circumvent|dobj|resistance 1,2-diaminocyclohexane-diacetato-dichloro-Pt|acl|circumvent ability|nmod|1,2-diaminocyclohexane-diacetato-dichloro-Pt END_ENTITY|nmod|ability	Role of p53 in the ability of 1,2-diaminocyclohexane-diacetato-dichloro-Pt -LRB- IV -RRB- to circumvent cisplatin resistance .
10653876	0	cisplatin	55,64	p53	20,23	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	sequence|nmod|START_ENTITY transfer|nmod|sequence transfer|nsubj|gene gene|compound|END_ENTITY	Adenovirus-mediated p53 gene transfer in sequence with cisplatin to tumors of patients with non-small-cell_lung_cancer .
10769661	0	cisplatin	43,52	p53	107,110	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	potentiation|nmod|START_ENTITY cytotoxicity|nsubj|potentiation cytotoxicity|xcomp|resulting resulting|nmod|introduction introduction|nmod|gene gene|compound|END_ENTITY	Sensitization and caffeine potentiation of cisplatin cytotoxicity resulting from introduction of wild-type p53 gene in human osteosarcoma .
10941537	0	cisplatin	55,64	p53	155,158	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	resistance|compound|START_ENTITY emergence|nmod|resistance chemotherapy|nmod|emergence Effect|nmod|chemotherapy glutathione|nsubj|Effect glutathione|dobj|levels levels|nmod|protein protein|compound|END_ENTITY	Effect of cisplatin-based chemotherapy on emergence of cisplatin resistance , and its correlation with intracellular glutathione levels and accumulation of p53 protein in human ovarian_cancer .
10958792	0	cisplatin	83,92	p53	51,54	cisplatin	p53	MESH:D002945	22060(Tax:10090)	Chemical	Gene	signal-regulated|nmod|START_ENTITY signal-regulated|nmod|accumulation accumulation|compound|END_ENTITY	Effect of extracellular signal-regulated kinase on p53 accumulation in response to cisplatin .
10958792	8	cisplatin	1210,1219	p53	1289,1292	cisplatin	ERK	MESH:D002945	26413(Tax:10090)	Chemical	Gene	exposure|compound|START_ENTITY decreased|nmod|exposure decreased|advcl|suggesting suggesting|ccomp|mediates mediates|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Furthermore , PD98059 decreased the phosphorylation of p53 at serine 15 during cisplatin exposure , suggesting that ERK1/2 mediates in part phosphorylation of p53 during the cisplatin DNA response .
10958792	8	cisplatin	1304,1313	p53	1289,1292	cisplatin	ERK	MESH:D002945	26413(Tax:10090)	Chemical	Gene	response|compound|START_ENTITY mediates|nmod|response mediates|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Furthermore , PD98059 decreased the phosphorylation of p53 at serine 15 during cisplatin exposure , suggesting that ERK1/2 mediates in part phosphorylation of p53 during the cisplatin DNA response .
11205289	0	cisplatin	88,97	p53	25,28	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	enhances|xcomp|START_ENTITY enhances|nsubj|Restoration Restoration|nmod|activity activity|compound|END_ENTITY	Restoration of wild-type p53 activity enhances the sensitivity of pleural metastasis to cisplatin through an apoptotic mechanism .
11295099	0	cisplatin	56,65	p53	125,128	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	radiation|amod|START_ENTITY response|nmod|radiation transcript|nmod|response Regulation|nmod|transcript correlated|nsubjpass|Regulation correlated|nmod|status status|compound|END_ENTITY	Regulation of BRCA1 and BRCA2 transcript in response to cisplatin , adriamycin , taxol and ionising radiation is correlated to p53 functional status in ovarian_cancer cell lines .
11435891	0	cisplatin	50,59	p53	24,27	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	confer|nmod|START_ENTITY confer|nsubj|forms forms|nmod|END_ENTITY	Various forms of mutant p53 confer sensitivity to cisplatin and doxorubicin in bladder_cancer cells .
12048682	0	cisplatin	97,106	p53	22,25	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	-RSB-|compound|START_ENTITY Effects|nmod|-RSB- Effects|nmod|gene gene|compound|END_ENTITY	-LSB- Effects of wild-type p53 gene on the chemotherapy sensitivity of ovarian_cancer SKOV-3 cells to cisplatin -RSB- .
12093475	0	cisplatin	190,199	p53	120,123	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	sensitivities|nmod|START_ENTITY lines|nmod|sensitivities status|nmod|lines status|compound|END_ENTITY	JM216 - , JM118 - , and cisplatin-induced cytotoxicity in relation to platinum-DNA adduct formation , glutathione levels and p53 status in human tumour cell lines with different sensitivities to cisplatin .
12197224	0	cisplatin	39,48	p53	9,12	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	resistance|compound|START_ENTITY predict|dobj|resistance predict|nsubj|staining staining|compound|END_ENTITY	Aberrant p53 staining does not predict cisplatin resistance in locally advanced non-small_cell_lung_cancer .
12209989	0	cisplatin	71,80	p53	10,13	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	therapy|compound|START_ENTITY degradation|nmod|therapy degradation|nsubj|Escape Escape|nmod|protein protein|compound|END_ENTITY	Escape of p53 protein from E6-mediated degradation in HeLa cells after cisplatin therapy .
12439598	0	cisplatin	34,43	p53	80,83	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	ERK|nmod|START_ENTITY activation|nmod|ERK induces|nsubj|activation induces|dobj|death death|nmod|END_ENTITY	Ras-mediated activation of ERK by cisplatin induces cell death independently of p53 in osteosarcoma and neuroblastoma cell lines .
12497212	0	cisplatin	15,24	p53	89,92	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	treatment|compound|START_ENTITY Sensitivity|nmod|treatment lines|amod|Sensitivity lines|nmod|END_ENTITY	Sensitivity to cisplatin treatment of human K1 thyroid_carcinoma cell lines with altered p53 function .
12668287	0	cisplatin	88,97	p53	38,41	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	receiving|dobj|START_ENTITY value|acl|receiving value|nmod|overexpression overexpression|nmod|END_ENTITY	Prognostic value of overexpression of p53 in human ovarian_carcinoma patients receiving cisplatin .
12694871	0	cisplatin	41,50	p53	84,87	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	modified|nmod|START_ENTITY modified|nmod|END_ENTITY	Recognition of DNA modified by antitumor cisplatin by `` latent '' and `` active '' protein p53 .
14654948	0	cisplatin	53,62	p53	12,15	cisplatin	p53	MESH:D002945	22060(Tax:10090)	Chemical	Gene	responses|nmod|START_ENTITY role|nmod|responses role|nmod|END_ENTITY	The role of p53 in the chemotherapeutic responses to cisplatin , doxorubicin and 5-fluorouracil treatment .
14683587	0	cisplatin	55,64	p53	118,121	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	combined|nmod|START_ENTITY combined|nmod|status status|compound|END_ENTITY	Effects of electrogenetherapy with p53wt combined with cisplatin on curvival of human tumor cell lines with different p53 status .
14693272	0	cisplatin	95,104	p53	11,14	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	cytotoxicity|nmod|START_ENTITY transfer|dep|cytotoxicity transfer|compound|END_ENTITY	Adenoviral p53 gene transfer in human bladder_cancer cell lines : cytotoxicity and synergy with cisplatin .
15113856	0	cisplatin	77,86	p53	40,43	cisplatin	p53	MESH:D002945	22060(Tax:10090)	Chemical	Gene	colonocytes|amod|START_ENTITY pathway|nmod|colonocytes pathway|compound|END_ENTITY	p73alpha is a candidate effector in the p53 independent apoptosis pathway of cisplatin damaged primary murine colonocytes .
15167899	0	cisplatin	28,37	p53	56,59	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	START_ENTITY|advcl|abrogating abrogating|dobj|response response|compound|END_ENTITY	Sensitizing_glioma cells to cisplatin by abrogating the p53 response with antisense oligonucleotides .
15386387	0	cisplatin	58,67	p53	9,12	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	response|nmod|START_ENTITY checkpoints|nmod|response checkpoints|compound|END_ENTITY	Aberrant p53 alters DNA damage checkpoints in response to cisplatin : downregulation of CDK expression and activity .
15452549	0	cisplatin	47,56	p53	126,129	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	treatment|compound|START_ENTITY events|nmod|treatment Characterisation|nmod|events Characterisation|dep|role role|nmod|induction induction|compound|END_ENTITY	Characterisation of molecular events following cisplatin treatment of two curable ovarian_cancer models : contrasting role for p53 induction and apoptosis in vivo .
15618970	0	cisplatin	99,108	p53	20,23	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	sensitization|nmod|START_ENTITY therapy|dep|sensitization therapy|compound|END_ENTITY	Adenovirus-mediated p53 gene therapy in pediatric soft-tissue sarcoma cell lines : sensitization to cisplatin and doxorubicin .
15990222	0	cisplatin	62,71	p53	13,16	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	treatment|nmod|START_ENTITY resistance|nmod|treatment resistance|compound|END_ENTITY	Induction of p53 and drug resistance following treatment with cisplatin or paclitaxel in ovarian_cancer cell lines .
16020667	0	cisplatin	12,21	p53	116,119	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	resistance|compound|START_ENTITY Reversal|nmod|resistance Reversal|dep|role role|nmod|END_ENTITY	Reversal of cisplatin resistance with a BH3 mimetic , -LRB- - -RRB- - gossypol , in head_and_neck_cancer cells : role of wild-type p53 and Bcl-xL .
16203773	0	cisplatin	8,17	p53	167,170	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	sensitivity|compound|START_ENTITY correlates|nsubj|sensitivity correlates|nmod|mutations mutations|acl|affecting affecting|dobj|signal signal|nmod|END_ENTITY	Reduced cisplatin sensitivity of head and neck_squamous_cell_carcinoma cell lines correlates with mutations affecting the COOH-terminal nuclear localization signal of p53 .
16211088	0	cisplatin	82,91	p53	20,23	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	sensitization|nmod|START_ENTITY therapy|dep|sensitization therapy|compound|END_ENTITY	Adenovirus-mediated p53 gene therapy in osteosarcoma cell lines : sensitization to cisplatin and doxorubicin .
16327987	0	cisplatin	125,134	p53	77,80	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	transduction|nmod|START_ENTITY Induction|acl|transduction Induction|nmod|END_ENTITY	Induction of p53-mediated apoptosis and recovery of chemosensitivity through p53 transduction in human glioblastoma cells by cisplatin .
16540663	0	cisplatin	13,22	p53	67,70	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	resistance|compound|START_ENTITY resistance|dep|modulation modulation|nmod|action action|compound|END_ENTITY	Akt-mediated cisplatin resistance in ovarian_cancer : modulation of p53 action on caspase-dependent mitochondrial death pathway .
16596182	0	cisplatin	58,67	p53	86,89	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	induced|nmod|START_ENTITY induced|nmod|absence absence|nmod|activation activation|compound|END_ENTITY	Cellular components involved in the cell death induced by cisplatin in the absence of p53 activation .
16644573	0	cisplatin	56,65	p53	0,3	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	sensitivity|compound|START_ENTITY correlate|nmod|sensitivity correlate|nsubj|mutation mutation|compound|END_ENTITY	p53 mutation and cyclin_D1 amplification correlate with cisplatin sensitivity in xenografted human squamous_cell_carcinomas from head and neck .
16815295	0	cisplatin	62,71	p53	84,87	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	START_ENTITY|advcl|blocking blocking|dobj|END_ENTITY	p73 and MDM2 confer the resistance of epidermoid_carcinoma to cisplatin by blocking p53 .
16981908	0	cisplatin	22,31	p53	73,76	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	modification|nmod|START_ENTITY affects|nsubj|modification affects|dobj|DNA DNA|nmod|proteins proteins|compound|END_ENTITY	DNA modification with cisplatin affects sequence-specific DNA binding of p53 and p73 proteins in a target site-dependent manner .
17431112	0	cisplatin	45,54	p53	94,97	cisplatin	p53	MESH:D002945	22060(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Luteolin sensitizes the anticancer effect of cisplatin via c-Jun NH2-terminal kinase-mediated p53 phosphorylation and stabilization .
17466278	0	cisplatin	64,73	p53	178,181	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	formation|nmod|START_ENTITY Accumulation|appos|formation characterized|nsubj|Accumulation characterized|nmod|status status|compound|END_ENTITY	Accumulation , platinum-DNA adduct formation and cytotoxicity of cisplatin , oxaliplatin and satraplatin in sensitive and resistant human osteosarcoma cell lines , characterized by p53 wild-type status .
17505786	0	cisplatin	13,22	p53	32,35	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	Apoptosis|nmod|START_ENTITY requires|nsubj|Apoptosis requires|ccomp|mediated mediated|nsubj|END_ENTITY	Apoptosis by cisplatin requires p53 mediated p38alpha MAPK activation through ROS generation .
17918180	0	cisplatin	13,22	p53	86,89	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	resistance|compound|START_ENTITY promotes|dobj|resistance promotes|nmod|inhibition inhibition|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Akt promotes cisplatin resistance in human ovarian_cancer cells through inhibition of p53 phosphorylation and nuclear function .
18064040	0	cisplatin	113,122	p53	74,77	cisplatin	p53	MESH:D002945	22060(Tax:10090)	Chemical	Gene	nephrotoxicity|compound|START_ENTITY _|nmod|nephrotoxicity _|nmod|END_ENTITY	Transcriptional activation of caspase-6_and _ -7 genes by cisplatin-induced p53 and its functional significance in cisplatin nephrotoxicity .
18454047	0	cisplatin	105,114	p53	45,48	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	drug|appos|START_ENTITY differ|nmod|drug responses|acl:relcl|differ responses|compound|END_ENTITY	The novel platinum -LRB- IV -RRB- complex LA-12 induces p53 and p53/47 responses that differ from the related drug , cisplatin .
18682572	0	cisplatin	43,52	p53	36,39	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	nephrotoxicity|compound|START_ENTITY role|nmod|nephrotoxicity role|nmod|END_ENTITY	Regulation and pathological role of p53 in cisplatin nephrotoxicity .
19094436	0	cisplatin	117,126	p53	98,101	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	injection|nmod|START_ENTITY injection|compound|END_ENTITY	Advanced malignant pleural_or_peritoneal_effusion in patients treated with recombinant adenovirus p53 injection plus cisplatin .
19217709	0	cisplatin	52,61	p53	8,11	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	cyclooxygenase-2|nmod|START_ENTITY lines|amod|cyclooxygenase-2 induction|nmod|lines Role|nmod|induction Role|nmod|END_ENTITY	Role of p53 in the induction of cyclooxygenase-2 by cisplatin or paclitaxel in non-small cell lung_cancer cell lines .
19444912	0	cisplatin	28,37	p53	97,100	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	resistance|compound|START_ENTITY resistance|nmod|variety variety|advmod|regardless regardless|nmod|status status|compound|END_ENTITY	APM2 is a novel mediator of cisplatin resistance in a variety of cancer cell types regardless of p53 or MMR status .
19548002	0	cisplatin	112,121	p53	22,25	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	treatment|compound|START_ENTITY lines|nmod|treatment cycle|nmod|lines influence|dobj|cycle influence|nsubj|overexpression overexpression|compound|END_ENTITY	Adenovirally mediated p53 overexpression diversely influence the cell cycle of HEp-2 and CAL 27 cell lines upon cisplatin and methotrexate treatment .
19934315	0	cisplatin	26,35	p53	101,104	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	hypersensitivity|compound|START_ENTITY induces|dobj|hypersensitivity induces|nmod|modulation modulation|nmod|transcriptional transcriptional|compound|END_ENTITY	Imatinib_mesylate induces cisplatin hypersensitivity in Bcr-Abl + cells by differential modulation of p53 transcriptional and proapoptotic activity .
20156675	0	cisplatin	42,51	p53	115,118	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	combination|nmod|START_ENTITY MI-319|nmod|combination treatment|nsubj|MI-319 treatment|nmod|pancreatic_cancer pancreatic_cancer|nmod|function function|compound|END_ENTITY	MDM2 inhibitor MI-319 in combination with cisplatin is an effective treatment for pancreatic_cancer independent of p53 function .
20386864	0	cisplatin	39,48	p53	28,31	cisplatin	p53	MESH:D002945	22060(Tax:10090)	Chemical	Gene	nephrotoxicity|compound|START_ENTITY induced|nmod|nephrotoxicity induced|nmod|END_ENTITY	MicroRNA-34a is induced via p53 during cisplatin nephrotoxicity and contributes to cell survival .
20655883	0	cisplatin	44,53	p53	100,103	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	chemosensitivity|compound|START_ENTITY chemosensitivity|nmod|up-regulation up-regulation|nmod|cells cells|amod|p73a p73a|nmod|squamous squamous|nummod|END_ENTITY	Polo-like_kinase1 -LRB- Plk1 -RRB- knockdown enhances cisplatin chemosensitivity via up-regulation of p73a in p53 mutant human epidermoid squamous carcinoma cells .
20811663	0	cisplatin	74,83	p53	0,3	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	not|nmod|START_ENTITY mutation|dep|not mutation|compound|END_ENTITY	p53 mutation , but not in vitro predictor genes of therapeutic efficacy of cisplatin , is clinically relevant in comparing partial and complete responder cases of maxillary_squamous_cell_carcinoma .
20868594	0	cisplatin	58,67	p53	40,43	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	combined|nmod|START_ENTITY combined|nsubj|Effect Effect|nmod|END_ENTITY	-LSB- Effect of recombinant human adenovirus p53 combined with cisplatin on the expression of human lung_adenocarcinoma A549 cell gene -RSB- .
21144296	5	cisplatin	732,741	p53	666,669	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	Ad-p53|appos|START_ENTITY treated|nmod|Ad-p53 treated|nsubjpass|lines lines|nmod|END_ENTITY	METHODS : Human lung_adenocarcinoma cell lines GLC-82 -LRB- including mutant p53 -RRB- and A549 -LRB- including wild-type p53 -RRB- were treated with Ad-p53 , cisplatin -LRB- DDP -RRB- or Ad-p53 + DDP respectively .
21258400	0	cisplatin	13,22	p53	39,42	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	resistance|compound|START_ENTITY resistance|nmod|manner manner|compound|END_ENTITY	ATR mediates cisplatin resistance in a p53 genotype-specific manner .
21266112	0	cisplatin	91,100	p53	31,34	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	line|nmod|START_ENTITY sensitization|nmod|line Effect|nmod|sensitization Effect|nmod|expression expression|compound|END_ENTITY	-LSB- Effect of exogenous wild type p53 expression on sensitization of lung_cancer cell line to cisplatin and cloning of the corresponding genes -RSB- .
21315017	0	cisplatin	72,81	p53	12,15	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	antisense|nmod|START_ENTITY antisense|nsubj|Effects Effects|nmod|END_ENTITY	-LSB- Effects of p53 antisense RNA on malignant phenotype and sensitivity to cisplatin of human lung_cancer cell line -RSB- .
21429301	0	cisplatin	63,72	p53	52,55	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	treatment|compound|START_ENTITY increases|nmod|treatment increases|dobj|apoptosis apoptosis|nmod|END_ENTITY	Vitamin_C increases the apoptosis via up-regulation p53 during cisplatin treatment in human colon_cancer cells .
21489989	0	cisplatin	72,81	p53	39,42	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	toxicity|amod|START_ENTITY gene|nmod|toxicity gene|compound|END_ENTITY	Serine/threonine kinase 17A is a novel p53 target gene and modulator of cisplatin toxicity and reactive oxygen species in testicular_cancer cells .
21532991	0	cisplatin	125,134	p53	0,3	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	cells|acl|START_ENTITY mechanism|dep|cells mechanism|nsubj|END_ENTITY	p53 hypersensitivity is the predominant mechanism of the unique responsiveness of testicular_germ_cell_tumor -LRB- TGCT -RRB- cells to cisplatin .
21660965	0	cisplatin	71,80	p53	106,109	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	START_ENTITY|nmod|stabilization stabilization|nmod|END_ENTITY	Knockdown of CITED2 using short-hairpin RNA sensitizes cancer cells to cisplatin through stabilization of p53 and enhancement of p53-dependent apoptosis .
21863213	0	cisplatin	114,123	p53	4,7	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	upregulated|advcl|START_ENTITY upregulated|nsubj|END_ENTITY	The p53 upregulated modulator of apoptosis -LRB- PUMA -RRB- chemosensitizes intrinsically resistant ovarian_cancer cells to cisplatin by lowering the threshold set by Bcl-x -LRB- L -RRB- and Mcl-1 .
22333583	0	cisplatin	135,144	p53	45,48	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	cells|acl|START_ENTITY active|nmod|cells make|xcomp|active make|nsubj|uptake uptake|nmod|status status|compound|END_ENTITY	Retained platinum uptake and indifference to p53 status make novel transplatinum agents active in platinum-resistant cells compared to cisplatin and oxaliplatin .
22674879	0	cisplatin	84,93	p53	21,24	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	induced|nmod|START_ENTITY arrest|acl|induced signal|nmod|arrest signal|nsubj|imaging imaging|nmod|END_ENTITY	Molecular imaging of p53 signal pathway in lung_cancer cell cycle arrest induced by cisplatin .
22679561	0	cisplatin	137,146	p53	14,17	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	affect|nmod|START_ENTITY affect|nsubj|Knock Knock|nmod|END_ENTITY	Knock down of p53 or its ubiquitin ligase E6AP does not affect the sensitivity of human_papillomavirus-positive_cervical_cancer cells to cisplatin .
22962266	0	cisplatin	70,79	p53	21,24	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	cue|nmod|START_ENTITY cue|dobj|response response|compound|END_ENTITY	Cancer cells cue the p53 response of cancer-associated_fibroblasts to cisplatin .
23300844	5	cisplatin	906,915	p53	844,847	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	genes|amod|START_ENTITY induced|nmod|genes that|acl|induced distinct|nmod|that distinct|nsubj|signature signature|compound|END_ENTITY	Low-dose 5-aza induces a p53 transcriptional signature distinct from that induced with cisplatin in NT2/D1 cells and also uniquely downregulates genes associated with pluripotency including NANOG , SOX2 , GDF3 and Myc target genes .
23351152	0	cisplatin	18,27	p53	84,87	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	sensitivity|compound|START_ENTITY sensitivity|nmod|cells cells|nmod|mutation mutation|compound|END_ENTITY	PRIMA-1 increases cisplatin sensitivity in chemoresistant ovarian_cancer cells with p53 mutation : a requirement for Akt down-regulation .
23555949	0	cisplatin	61,70	p53	101,104	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	produces|nmod|START_ENTITY produces|advcl|increasing increasing|dobj|levels levels|compound|END_ENTITY	Zoledronic_acid produces combinatory anti-tumor effects with cisplatin on mesothelioma by increasing p53 expression levels .
23726840	0	cisplatin	31,40	p53	161,164	cisplatin	p53	MESH:D002945	22060(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY Enhanced|dobj|effect Enhanced|advcl|transfecting transfecting|dobj|attenuated_Salmonella attenuated_Salmonella|acl|carrying carrying|dobj|gene gene|compound|END_ENTITY	Enhanced therapeutic effect of cisplatin on the prostate_cancer in tumor-bearing mice by transfecting the attenuated_Salmonella carrying a plasmid co-expressing p53 gene and mdm2 siRNA .
23833193	0	cisplatin	21,30	p53	79,82	cisplatin	p53	MESH:D002945	22060(Tax:10090)	Chemical	Gene	sensitivity|compound|START_ENTITY sensitivity|nmod|modulation modulation|nmod|END_ENTITY	Piceatannol enhances cisplatin sensitivity in ovarian_cancer via modulation of p53 , X-linked_inhibitor_of_apoptosis_protein -LRB- XIAP -RRB- , and mitochondrial fission .
23839309	0	cisplatin	32,41	p53	119,122	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	resistance|compound|START_ENTITY secondary|nsubj|resistance secondary|nmod|loss loss|nmod|END_ENTITY	Chk1/2 inhibition overcomes the cisplatin resistance of head_and_neck cancer cells secondary to the loss of functional p53 .
23970333	0	cisplatin	29,38	p53	0,3	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	resistance|compound|START_ENTITY overcome|dobj|resistance overcome|nsubj|restoration restoration|compound|END_ENTITY	p53 restoration can overcome cisplatin resistance through inhibition of Akt as well as induction of Bax .
24173208	0	cisplatin	32,41	p53	55,58	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	induction|nmod|START_ENTITY role|dep|induction role|nmod|END_ENTITY	Autophagy induction by low-dose cisplatin : the role of p53 in autophagy .
24595063	0	cisplatin	26,35	p53	95,98	cisplatin	p53	MESH:D002945	301300(Tax:10116)	Chemical	Gene	sensitivity|compound|START_ENTITY decreases|dobj|sensitivity decreases|advcl|downregulating downregulating|dobj|END_ENTITY	Vasohibin_2 decreases the cisplatin sensitivity of hepatocarcinoma cell line by downregulating p53 .
25220870	0	cisplatin	102,111	p53	13,16	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	sensitization|compound|START_ENTITY involved|nmod|sensitization involved|nsubjpass|Promotion Promotion|nmod|expression expression|compound|END_ENTITY	Promotion of p53 expression and reactive oxidative stress production is involved in zerumbone-induced cisplatin sensitization of non-small_cell_lung_cancer cells .
25622680	0	cisplatin	37,46	p53	88,91	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	START_ENTITY|nmod|-RSB- -RSB-|nummod|END_ENTITY	-LSB- p14ARF enhances chemosensitivity to cisplatin in human osteosarcoma U2OS cells through p53 apoptotic pathway -RSB- .
25809501	0	cisplatin	94,103	p53	43,46	cisplatin	p53	MESH:D002945	301300(Tax:10116)	Chemical	Gene	injured|nmod|START_ENTITY cells|acl|injured causes|nmod|cells causes|dobj|accumulation accumulation|compound|END_ENTITY	Phlda3 , a urine-detectable protein , causes p53 accumulation in renal tubular cells injured by cisplatin .
26384430	0	cisplatin	44,53	p53	68,71	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	START_ENTITY|advcl|inhibiting inhibiting|dobj|trans-activation trans-activation|compound|END_ENTITY	CITED2 silencing sensitizes cancer cells to cisplatin by inhibiting p53 trans-activation and chromatin relaxation on the ERCC1 DNA repair gene .
26768586	8	cisplatin	1062,1071	p53	1030,1033	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	increased|nmod|START_ENTITY increased|nsubjpass|expression expression|compound|END_ENTITY	Moreover , p53 expression was increased by cisplatin .
27050276	0	cisplatin	97,106	p53	74,77	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	sensitivity|compound|START_ENTITY determines|dobj|sensitivity determines|nsubj|END_ENTITY	Crosstalk between the IGF-1R / AKT/mTORC1 pathway and the tumor suppressors p53 and p27 determines cisplatin sensitivity and limits the effectiveness of an IGF-1R pathway inhibitor .
7712469	0	cisplatin	67,76	p53	14,17	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	sensitizes|nmod|START_ENTITY sensitizes|nsubj|Disruption Disruption|nmod|function function|compound|END_ENTITY	Disruption of p53 function sensitizes breast_cancer MCF-7 cells to cisplatin and pentoxifylline .
8564971	0	cisplatin	20,29	p53	57,60	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	resistance|compound|START_ENTITY Association|nmod|resistance Association|nmod|gene gene|compound|END_ENTITY	Association between cisplatin resistance and mutation of p53 gene and reduced bax expression in ovarian_carcinoma cell systems .
8653690	0	cisplatin	99,108	p53	14,17	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	resistance|compound|START_ENTITY Modulation|nmod|resistance Modulation|nmod|expression expression|compound|END_ENTITY	Modulation of p53 expression by human recombinant interferon-alpha2a correlates with abrogation of cisplatin resistance in a human melanoma cell line .
8760308	0	cisplatin	46,55	p53	13,16	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|sensitivity sensitivity|compound|END_ENTITY	Induction of p53 and increased sensitivity to cisplatin in ataxia-telangiectasia cells .
8920796	0	cisplatin	92,101	p53	14,17	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of p53 and apoptosis of tumor cells in locally advanced cervical_carcinoma after cisplatin based neoadjuvant chemotherapy .
9010220	0	cisplatin	77,86	p53	18,21	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	confer|nmod|START_ENTITY elements|acl:relcl|confer elements|nummod|END_ENTITY	Identification of p53 genetic suppressor elements which confer resistance to cisplatin .
9013707	0	cisplatin	126,135	p53	54,57	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	chemosensitivity|compound|START_ENTITY cyclin_G|nmod|chemosensitivity cyclin_G|nsubj|effectors effectors|nummod|END_ENTITY	The p53-regulated cyclin_G gene promotes cell growth : p53 downstream effectors cyclin_G and Gadd45 exert different effects on cisplatin chemosensitivity .
9212237	0	cisplatin	27,36	p53	133,136	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	Mechanism|acl|START_ENTITY Mechanism|dep|role role|nmod|END_ENTITY	Mechanism of resistance to cisplatin in a human ovarian-carcinoma cell line selected for resistance to doxorubicin : possible role of p53 .
9485023	0	cisplatin	41,50	p53	24,27	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	induction|nmod|START_ENTITY induction|nsubj|pathways pathways|nmod|END_ENTITY	Independent pathways of p53 induction by cisplatin and X-rays in a cisplatin-resistant ovarian_tumor cell line .
9488309	0	cisplatin	48,57	p53	101,104	cisplatin	p53	MESH:D002945	301300(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|restoration restoration|nmod|function function|compound|END_ENTITY	Sensitization of rat glioblastoma multiforme to cisplatin in vivo following restoration of wild-type p53 function .
9700726	0	cisplatin	48,57	p53	26,29	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	damage_of_ovarian_cells|compound|START_ENTITY activities|nmod|damage_of_ovarian_cells activities|nmod|protein protein|compound|END_ENTITY	DNA binding activities of p53 protein following cisplatin damage_of_ovarian_cells .
9731490	7	cisplatin	1181,1190	p53	1115,1118	cisplatin	p53	MESH:D002945	7157	Chemical	Gene	resistance|nmod|START_ENTITY affects|dobj|resistance affects|nsubj|function function|compound|END_ENTITY	Given the role of p53 in the response of cells to irradiation , we evaluated whether p53 function affects the observed radiation-induced resistance to cisplatin .
21308351	0	cisplatin	76,85	riboflavin_kinase	15,32	cisplatin	riboflavin kinase	MESH:D002945	55312	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|expression expression|amod|END_ENTITY	Involvement of riboflavin_kinase expression in cellular sensitivity against cisplatin .
24086535	0	cisplatin	43,52	rictor	21,27	cisplatin	rictor	MESH:D002945	253260	Chemical	Gene	contributes|xcomp|START_ENTITY contributes|nsubj|END_ENTITY	The mTORC2 component rictor contributes to cisplatin resistance in human ovarian_cancer cells .
16196027	0	cisplatin	54,63	transferrin	75,86	cisplatin	transferrin	MESH:D002945	7018	Chemical	Gene	spectrometric|nmod|START_ENTITY binding|nsubj|spectrometric binding|xcomp|END_ENTITY	A mass spectrometric and molecular modelling study of cisplatin binding to transferrin .
26942448	0	cisplatin	122,131	transferrin	43,54	cisplatin	transferrin	MESH:D002945	7018	Chemical	Gene	nanomedicine|nmod|START_ENTITY nanomedicine|amod|END_ENTITY	Targeted_hepatocellular_carcinoma therapy : transferrin modified , self-assembled polymeric nanomedicine for co-delivery of cisplatin and doxorubicin .
22330679	0	cisplatin	31,40	tumor_necrosis_factor	68,89	cisplatin	tumor necrosis factor	MESH:D002945	21926(Tax:10090)	Chemical	Gene	START_ENTITY|acl|mediated mediated|nmod|END_ENTITY	DR3 signaling protects against cisplatin nephrotoxicity mediated by tumor_necrosis_factor .
2767524	0	cisplatin	91,100	tumor_necrosis_factor	49,70	cisplatin	tumor necrosis factor	MESH:D002945	7124	Chemical	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	In vitro analysis of the anticancer potential of tumor_necrosis_factor in combination with cisplatin .
15868905	0	cisplatin	85,94	tumor_necrosis_factor-alpha	19,46	cisplatin	tumor necrosis factor-alpha	MESH:D002945	24835(Tax:10116)	Chemical	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	Effect of low-dose tumor_necrosis_factor-alpha in combination with STEALTH liposomal cisplatin -LRB- SPI-077 -RRB- on soft-tissue - and osteosarcoma-bearing rats .
16681723	0	cisplatin	102,111	tumor_necrosis_factor-related_apoptosis-inducing_ligand	32,87	cisplatin	tumor necrosis factor-related apoptosis-inducing ligand	MESH:D002945	8743	Chemical	Gene	combined|nmod|START_ENTITY combined|nsubj|effect effect|nmod|END_ENTITY	Synergistic antitumor effect of tumor_necrosis_factor-related_apoptosis-inducing_ligand combined with cisplatin in ovarian_carcinoma cell lines in vitro and in vivo .
12644815	0	cisplatin	41,50	vp16	80,84	cisplatin	vp16	MESH:D002945	3054	Chemical	Gene	escalation|nmod|START_ENTITY intrapatient|dobj|escalation intrapatient|nmod|END_ENTITY	Adaptive intrapatient dose escalation of cisplatin in combination with low-dose vp16 in patients with nonsmall_cell_lung_cancer .
3020707	0	cisplatin_and_oral_etoposide	32,60	VP-16	62,67	cisplatin and oral etoposide	VP-16	null	3054	Chemical	Gene	trial|nmod|START_ENTITY trial|appos|END_ENTITY	A multicenter phase II trial of cisplatin_and_oral_etoposide -LRB- VP-16 -RRB- in inoperable non-small-cell_lung_cancer .
1851142	0	cisplatinum	75,86	alpha-2a_interferon	31,50	cisplatinum	alpha-2a interferon	MESH:D002945	3440	Chemical	Gene	trial|nmod|START_ENTITY trial|nmod|END_ENTITY	A phase I trial of recombinant alpha-2a_interferon -LRB- Roferon-A -RRB- with weekly cisplatinum .
10229070	0	citalopram	72,82	5-HT2C	0,6	citalopram	5-HT2C	MESH:D015283	25187(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY involved|nmod|effects involved|nsubjpass|receptors receptors|nummod|END_ENTITY	5-HT2C receptors are involved in the discriminative stimulus effects of citalopram in rats .
22412189	0	citalopram	14,24	CRF	37,40	citalopram	CRF	MESH:D015283	1392	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nsubj|effect	The effect of citalopram on midbrain CRF receptors 1 and 2 in a primate model of stress-induced amenorrhea .
10877005	0	citalopram	20,30	CYP1A2	114,120	citalopram	CYP1A2	MESH:D015283	1544	Chemical	Gene	melatonin|compound|START_ENTITY melatonin|dep|indication indication|acl:relcl|cytochrome cytochrome|dobj|END_ENTITY	Fluvoxamine but not citalopram increases serum melatonin in healthy subjects -- an indication that cytochrome P450 CYP1A2 and CYP2C19 hydroxylate melatonin .
8880055	0	citalopram	59,69	CYP1A2	29,35	citalopram	CYP1A2	MESH:D015283	1544	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Dose-dependent inhibition of CYP1A2 , CYP2C19 and CYP2D6 by citalopram , fluoxetine , fluvoxamine and paroxetine .
12975335	0	citalopram	20,30	CYP2C19	70,77	citalopram	CYP2C19	MESH:D015283	1557	Chemical	Gene	Pharmacokinetics|nmod|START_ENTITY Pharmacokinetics|nmod|END_ENTITY	Pharmacokinetics of citalopram in relation to genetic polymorphism of CYP2C19 .
20531370	0	citalopram	64,74	CYP2C19	20,27	citalopram	CYP2C19	MESH:D015283	1557	Chemical	Gene	START_ENTITY|nsubj|Association Association|nmod|END_ENTITY	Association between CYP2C19 * 17 and metabolism of amitriptyline , citalopram and clomipramine in Dutch hospitalized patients .
25571636	0	citalopram	12,22	PCNA	44,48	citalopram	PCNA	MESH:D015283	25737(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of citalopram on the expression of PCNA and C-fos and cell apoptosis in rat frontal cortical neurons after stress -RSB- .
12581014	0	citalopram	76,86	leptin	6,12	citalopram	leptin	MESH:D015283	3952	Chemical	Gene	treatment|compound|START_ENTITY Serum|nmod|treatment Serum|dobj|levels levels|compound|END_ENTITY	Serum leptin levels in patients with premature_ejaculation before and after citalopram treatment .
18478022	0	citalopram	11,21	serotonin_transporter	38,59	citalopram	serotonin transporter	MESH:D015283	6532	Chemical	Gene	infusion|compound|START_ENTITY infusion|nmod|END_ENTITY	Effects of citalopram infusion on the serotonin_transporter binding of -LSB- 11C -RSB- DASB in healthy controls .
23168018	0	citalopram	20,30	serotonin_transporter	85,106	citalopram	serotonin transporter	MESH:D015283	6532	Chemical	Gene	analogue|compound|START_ENTITY analogue|nmod|END_ENTITY	A rhodamine-labeled citalopram analogue as a high-affinity fluorescent probe for the serotonin_transporter .
12018475	0	citrate	6,13	CD71	71,75	citrate	CD71	MESH:D019343	7037	Chemical	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Serum citrate levels , haptoglobin haplotypes and transferrin receptor -LRB- CD71 -RRB- in patients with HIV-1_infection .
7984086	0	citrate	81,88	CIT1	104,108	citrate	CIT1	MESH:D019343	855732(Tax:4932)	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The HAP2 ,3,4 transcriptional activator is required for derepression of the yeast citrate synthase gene , CIT1 .
9244391	0	citrate	168,175	CIT1	149,153	citrate	CIT1	MESH:D019343	855732(Tax:4932)	Chemical	Gene	synthase|amod|START_ENTITY encoding|dobj|synthase suppressed|xcomp|encoding suppressed|nmod|mutations mutations|nmod|gene gene|compound|END_ENTITY	Mutations in the IDH2 gene encoding the catalytic subunit of the yeast NAD + - dependent isocitrate dehydrogenase can be suppressed by mutations in the CIT1 gene encoding citrate synthase and other genes of oxidative metabolism .
21115655	0	citrate	53,60	IL1403	101,107	citrate	IL1403	MESH:D019343	3173391(Tax:283942)	Chemical	Gene	pathway|amod|START_ENTITY pathway|nmod|END_ENTITY	Citrate uptake in exchange with intermediates in the citrate metabolic pathway in Lactococcus_lactis IL1403 .
17184967	0	citrate	35,42	Insulin	0,7	citrate	Insulin	MESH:D019343	3630	Chemical	Gene	START_ENTITY|nsubj|resistance resistance|compound|END_ENTITY	Insulin resistance and low urinary citrate excretion in calcium_stone formers .
9922982	0	citrate	29,36	MX1	38,41	citrate	MX1	MESH:D019343	24575(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of roxatidine bismuth citrate -LRB- MX1 -RRB- against acetylsalicylic_acid - and indomethacin-induced gastric_mucosal_damage in rats .
24103422	0	citrate	34,41	Mcl-1	14,19	citrate	Mcl-1	MESH:D019343	4170	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Inhibition of Mcl-1 expression by citrate enhances the effect of Bcl-xL inhibitors on human ovarian_carcinoma cells .
12177002	0	citrate	70,77	NaCT	91,95	citrate	NaCT	MESH:D019343	9058	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Structure , function , and expression pattern of a novel sodium-coupled citrate transporter -LRB- NaCT -RRB- cloned from mammalian brain .
16973915	0	citrate	61,68	NaCT	38,42	citrate	NaCT	MESH:D019343	284111	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|appos|transporter	Expression and functional features of NaCT , a sodium-coupled citrate transporter , in human and rat livers and cell lines .
26620127	0	citrate	73,80	NaCT	94,98	citrate	NaCT	C102006	284111	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Discovery and characterization of novel inhibitors of the sodium-coupled citrate transporter -LRB- NaCT or SLC13A5 -RRB- .
2385549	0	citrate	30,37	Prolactin	0,9	citrate	Prolactin	MESH:D019343	24683(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Prolactin directly stimulates citrate production and mitochondrial aspartate aminotransferase of prostate epithelial cells .
8609829	0	citrate	33,40	Prolactin	0,9	citrate	Prolactin	MESH:D019343	24683(Tax:10116)	Chemical	Gene	oxidation|amod|START_ENTITY regulates|dobj|oxidation regulates|nsubj|END_ENTITY	Prolactin specifically regulates citrate oxidation and m-aconitase of rat prostate epithelial cells .
7285903	1	citrate	179,186	fumarase	147,155	citrate	fumarase	MESH:D019343	2271	Chemical	Gene	synthesis|amod|START_ENTITY synthesis|amod|END_ENTITY	A study involving fumarase , malate_dehydrogenase , citrate synthesis and aspartate aminotransferase .
7285903	1	citrate	179,186	malate_dehydrogenase	157,177	citrate	malate dehydrogenase	MESH:D019343	4199	Chemical	Gene	synthesis|amod|START_ENTITY synthesis|amod|END_ENTITY	A study involving fumarase , malate_dehydrogenase , citrate synthesis and aspartate aminotransferase .
7676467	0	citrate	16,23	phospholipase_A2	33,49	citrate	phospholipase A2	MESH:D019343	406141(Tax:7460)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Arthropod venom citrate inhibits phospholipase_A2 .
3114026	0	citrate	23,30	prolactin	73,82	citrate	prolactin	MESH:D019343	24683(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY control|nmod|production control|nmod|END_ENTITY	Independent control of citrate production and ornithine_decarboxylase by prolactin in the lateral lobe of the rat prostate .
22611924	0	citreoviridin	12,25	MCP-1	47,52	citreoviridin	MCP-1	MESH:C014416	6347	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of citreoviridin on the expression of MCP-1 and ILs induced by TNF-alpha in vein endothelial cells -RSB- .
2523213	0	citreoviridin	10,23	mitochondrial_ATPase	59,79	citreoviridin	mitochondrial ATPase	MESH:C014416	514	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of citreoviridin and isocitreoviridin on beef heart mitochondrial_ATPase .
17443871	0	citric_acid	90,101	HCN	52,55	citric acid	HCN	MESH:D019343	378938	Chemical	Gene	START_ENTITY|nsubj|relationship relationship|nmod|END_ENTITY	On a hypothetical generational relationship between HCN and constituents of the reductive citric_acid cycle .
2946386	7	citric_acid	1600,1611	OGDH	1619,1623	citric acid	OGDH	MESH:D019343	4967	Chemical	Gene	pathways|amod|START_ENTITY pathways|appos|END_ENTITY	However , genetic factors appear to be involved in the variation of regulatory enzymes of the glycolytic -LRB- PFK -RRB- and citric_acid cycle -LRB- OGDH -RRB- pathways and in the variation of the oxidative to glycolytic activity ratio -LRB- PFK/OGDH ratio -RRB- .
11472797	0	citric_acid	16,27	Y-1095	63,69	citric acid	Y-1095	MESH:D019343	1149239(Tax:187410)	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Optimization of citric_acid production from Candida_lipolytica Y-1095 using n-paraffin .
12112629	0	citrinin	15,23	interferon-gamma	55,71	citrinin	interferon-gamma	MESH:D002953	3458	Chemical	Gene	affect|nsubj|START_ENTITY affect|dobj|END_ENTITY	The mycotoxins citrinin , gliotoxin , and patulin affect interferon-gamma rather than interleukin-4 production in human blood cells .
12631273	0	citropin	86,94	nNOS	0,4	citropin	nNOS	null	4842	Chemical	Gene	START_ENTITY|nsubj|inhibition inhibition|amod|END_ENTITY	nNOS inhibition , antimicrobial and anticancer activity of the amphibian skin peptide , citropin 1.1 and synthetic modifications .
21769486	0	citrullinated_vimentin	30,52	CD4	5,8	citrullinated vimentin	CD4	null	920	Chemical	Gene	+|nmod|START_ENTITY +|nsubj|END_ENTITY	Weak CD4 + T-cell responses to citrullinated_vimentin in rheumatoid_arthritis patients carrying HLA-DR9 alleles .
2731546	0	citryl-CoA	50,60	citrate_synthase	28,44	citryl-CoA	citrate synthase	MESH:C029890	397519(Tax:9823)	Chemical	Gene	Mechanism|nmod|START_ENTITY Mechanism|nmod|END_ENTITY	Mechanism of interaction of citrate_synthase with citryl-CoA .
15147461	0	cladribine	109,119	Interleukin-8	0,13	cladribine	Interleukin-8	MESH:D017338	3576	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|levels levels|compound|END_ENTITY	Interleukin-8 and RANTES levels in patients with relapsing-remitting multiple_sclerosis -LRB- RR-MS -RRB- treated with cladribine .
21679466	0	cladribine	25,35	STAT3	56,61	cladribine	STAT3	MESH:D017338	6774	Chemical	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	Therapeutic potential of cladribine in combination with STAT3 inhibitor against multiple_myeloma .
11552664	0	cladribine	10,20	intercellular_adhesion_molecule_1	67,100	cladribine	intercellular adhesion molecule 1	MESH:D017338	3383	Chemical	Gene	treatment|amod|START_ENTITY Effect|nmod|treatment Effect|nmod|END_ENTITY	Effect of cladribine treatment on beta-2_microglobulin and soluble intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- in patients with multiple_sclerosis .
22404374	0	clarithromycin	9,23	CD4	42,45	clarithromycin	CD4	MESH:D017291	12504(Tax:10090)	Chemical	Gene	modulates|compound|START_ENTITY END_ENTITY|nsubj|modulates	Low-dose clarithromycin therapy modulates CD4 -LRB- + -RRB- T-cell responses in a mouse model of chronic_Pseudomonas_aeruginosa_lung_infection .
19884323	0	clarithromycin	86,100	CYP3A	77,82	clarithromycin	CYP3A	MESH:D017291	1576	Chemical	Gene	based|nmod|START_ENTITY based|dobj|model model|nmod|inhibition inhibition|nmod|END_ENTITY	Physiologically based pharmacokinetic model of mechanism-based inhibition of CYP3A by clarithromycin .
22777148	0	clarithromycin	61,75	CYP3A	52,57	clarithromycin	CYP3A	MESH:D017291	1576	Chemical	Gene	Rate|nmod|START_ENTITY Rate|nmod|inhibition inhibition|nmod|END_ENTITY	Rate of onset of inhibition of gut-wall and hepatic CYP3A by clarithromycin .
25106415	0	clarithromycin	55,69	CYP3A	9,14	clarithromycin	CYP3A	MESH:D017291	1576	Chemical	Gene	alternatives|amod|START_ENTITY alternatives|compound|END_ENTITY	Clinical CYP3A inhibitor alternatives to ketoconazole , clarithromycin and itraconazole , are not transported into the liver by hepatic organic anion transporting polypeptides and organic_cation_transporter_1 .
10615065	0	clarithromycin	33,47	Interleukin-8	0,13	clarithromycin	Interleukin-8	MESH:D017291	3576	Chemical	Gene	repression|nmod|START_ENTITY repression|amod|END_ENTITY	Interleukin-8 gene repression by clarithromycin is mediated by the activator protein-1 binding site in human bronchial epithelial cells .
21042828	0	clarithromycin	26,40	MCP-1	66,71	clarithromycin	MCP-1	MESH:D017291	6347	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|levels levels|amod|END_ENTITY	Renoprotective effects of clarithromycin via reduction of urinary MCP-1 levels in type 2 diabetic patients .
9695727	0	clarithromycin	10,24	P-glycoprotein	73,87	clarithromycin	P-glycoprotein	MESH:D017291	5243	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|interaction interaction|nmod|END_ENTITY	Effect of clarithromycin on renal excretion of digoxin : interaction with P-glycoprotein .
23748747	0	clarithromycin	32,46	SLCO1B1	81,88	clarithromycin	SLCO1B1	MESH:D017291	10599	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of ambrisentan with clarithromycin and its modulation by polymorphic SLCO1B1 .
9874281	0	clarithromycin	10,24	alpha1-acid_glycoprotein	28,52	clarithromycin	alpha1-acid glycoprotein	MESH:D017291	24614(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|amod|END_ENTITY	Effect of clarithromycin on alpha1-acid_glycoprotein levels in normal and diabetic rats .
2527301	0	clarithromycin	11,25	cytochrome_P-450	29,45	clarithromycin	cytochrome P-450	MESH:D017291	25251(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of clarithromycin on cytochrome_P-450 .
9951426	0	clarithromycin	10,24	cytochrome_P450_2D6	128,147	clarithromycin	cytochrome P450 2D6	MESH:D017291	1565	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of clarithromycin on the pharmacokinetics and pharmacodynamics of pimozide in healthy poor and extensive metabolizers of cytochrome_P450_2D6 -LRB- CYP2D6 -RRB- .
12070169	0	clathrin	50,58	arrestin-2	22,32	clathrin	arrestin-2	null	408	Chemical	Gene	interaction|nmod|START_ENTITY interaction|amod|END_ENTITY	Differential roles of arrestin-2 interaction with clathrin and adaptor protein 2 in G protein-coupled receptor trafficking .
3770593	0	clavine_alkaloids	26,43	hydroxymethylglutaryl-CoA_reductase	60,95	clavine alkaloids	hydroxymethylglutaryl-CoA reductase	MESH:D004876	3156	Chemical	Gene	production|nmod|START_ENTITY production|nmod|END_ENTITY	Saprophytic production of clavine_alkaloids and activity of hydroxymethylglutaryl-CoA_reductase .
6777202	0	clebopride	22,32	prolactin	42,51	clebopride	prolactin	MESH:C014417	5617	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|compound|END_ENTITY	Stimulatory effect of clebopride on human prolactin secretion .
10338295	0	clenbuterol	31,42	Bcl-2	53,58	clenbuterol	Bcl-2	MESH:D002976	24224(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|compound|END_ENTITY	The beta2-adrenoceptor agonist clenbuterol modulates Bcl-2 , Bcl-xl and Bax protein expression following transient forebrain_ischemia .
7938235	0	clenbuterol	11,22	a_beta	24,30	clenbuterol	a beta	MESH:D002976	54226(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Effects of clenbuterol , a_beta 2-adrenoceptor agonist , on macronutrient selection in rats .
20033361	0	clenbuterol	38,49	beta2-adrenoceptor	67,85	clenbuterol	beta2-adrenoceptor	MESH:D002976	24176(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|mRNA mRNA|amod|END_ENTITY	Adaptive effects of the beta2-agonist clenbuterol on expression of beta2-adrenoceptor mRNA in rat fast-twitch fiber-rich muscles .
1301352	0	clenbuterol	86,97	beta_2-adrenoceptor	57,76	clenbuterol	beta 2-adrenoceptor	MESH:D002976	24176(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Hemodynamic effects on hepatic blood flow of a selective beta_2-adrenoceptor agonist , clenbuterol , in rat .
1322047	0	clenbuterol	20,31	beta_2-adrenoceptor	67,86	clenbuterol	beta 2-adrenoceptor	MESH:D002976	24176(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY mediated|nsubjpass|effects mediated|nmod|activation activation|amod|END_ENTITY	Anabolic effects of clenbuterol on skeletal muscle are mediated by beta_2-adrenoceptor activation .
1693748	0	clenbuterol	44,55	beta_2-adrenoceptor	15,34	clenbuterol	beta 2-adrenoceptor	MESH:D002976	24176(Tax:10116)	Chemical	Gene	due|amod|START_ENTITY deprivation|amod|due deprivation|amod|END_ENTITY	Effects of the beta_2-adrenoceptor agonist , clenbuterol , on muscle_atrophy due to food deprivation in the rat .
2551300	0	clenbuterol	43,54	beta_2-adrenoceptor	15,34	clenbuterol	beta 2-adrenoceptor	MESH:D002976	24176(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|agonist agonist|amod|END_ENTITY	Effects of the beta_2-adrenoceptor agonist clenbuterol on tyrosine and tryptophan in plasma and brain of the rat .
2936976	0	clenbuterol	33,44	beta_2-adrenoceptor	4,23	clenbuterol	beta 2-adrenoceptor	MESH:D002976	11555(Tax:10090)	Chemical	Gene	agonists|amod|START_ENTITY agonists|amod|END_ENTITY	The beta_2-adrenoceptor agonists clenbuterol and salbutamol enhance the hypothermic action of 8-hydroxy-2 - -LRB- di-n-propylamino -RRB- tetralin -LRB- 8-OH-DPAT -RRB- in mice by a central mechanism .
2101962	0	clenbuterol	13,24	growth_hormone	76,90	clenbuterol	growth hormone	MESH:D002976	2688	Chemical	Gene	Influence|nmod|START_ENTITY Influence|acl|induced induced|dobj|stimulation stimulation|amod|END_ENTITY	Influence of clenbuterol , a_beta-adrenergic agonist , on desipramine induced growth_hormone , prolactin and cortisol stimulation .
11408417	0	clenbuterol	81,92	monocarboxylate_transporter_1	10,39	clenbuterol	monocarboxylate transporter 1	MESH:D002976	25027(Tax:10116)	Chemical	Gene	exposed|xcomp|START_ENTITY exposed|nsubj|END_ENTITY	Decreased monocarboxylate_transporter_1 in rat soleus and EDL muscles exposed to clenbuterol .
7720824	0	clenbuterol	83,94	nerve_growth_factor	13,32	clenbuterol	nerve growth factor	MESH:D002976	310738(Tax:10116)	Chemical	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	Induction of nerve_growth_factor and basic_fibroblast_growth_factor mRNA following clenbuterol : contrasting anatomical and cellular localization .
17638340	0	clerodane_diterpenoids	39,61	kappa-opioid_receptor	111,132	clerodane diterpenoids	kappa-opioid receptor	null	4986	Chemical	Gene	modification|nmod|START_ENTITY modification|nmod|END_ENTITY	Isolation and chemical modification of clerodane_diterpenoids from Salvia species as potential agonists at the kappa-opioid_receptor .
16501008	0	clevidipine	60,71	cytochrome_p450	6,21	clevidipine	cytochrome p450	MESH:C118563	4051	Chemical	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Human cytochrome_p450 induction and inhibition potential of clevidipine and its primary metabolite h152/81 .
3144525	0	clindamycin	50,61	beta-lactamase	190,204	clindamycin	beta-lactamase	MESH:D002981	4290808(Tax:287)	Chemical	Gene	interactions|nmod|START_ENTITY caused|nsubj|interactions caused|nmod|strain strain|amod|END_ENTITY	In-vitro and in-vivo bacterocodal interactions of clindamycin and ceftazidime , by non-beta-lactamase mechanisms , in experimental Pseudomonas_aeruginosa endocarditis caused by a constitutive beta-lactamase overproducing strain .
7920440	0	clindamycin	21,32	beta-lactamase	50,64	clindamycin	beta-lactamase	MESH:D002981	4290808(Tax:287)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Inhibitory effect of clindamycin on production of beta-lactamase in beta-lactam-resistant bacteria .
18927074	0	clioquinol	32,42	CLK-1	81,86	clioquinol	CLK-1	MESH:D007464	1195	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	The anti-neurodegeneration drug clioquinol inhibits the aging-associated protein CLK-1 .
22248233	0	clioquinol	33,43	FOXO1a	79,85	clioquinol	FOXO1a	MESH:D007464	2308	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	The anti-neurodegenerative agent clioquinol regulates the transcription factor FOXO1a .
21113977	0	clofarabine	57,68	S0530	31,36	clofarabine	S0530	MESH:C068329	1078851(Tax:198215)	Chemical	Gene	trial|nmod|START_ENTITY END_ENTITY|dep|trial	Southwest Oncology Group Study S0530 : a phase 2 trial of clofarabine and cytarabine for relapsed or refractory acute_lymphocytic_leukaemia .
21115912	0	clofarabine	13,24	ZAP70	74,79	clofarabine	ZAP70	MESH:C068329	7535	Chemical	Gene	genes|amod|START_ENTITY genes|compound|END_ENTITY	Influence of clofarabine on transcriptional activity of PTEN , APC , RARB2 , ZAP70 genes in K562 cells .
16421443	0	clofarabine	60,71	deoxycytidine_kinase	23,43	clofarabine	deoxycytidine kinase	MESH:C068329	1633	Chemical	Gene	complex|nmod|START_ENTITY END_ENTITY|nmod|complex	The structure of human deoxycytidine_kinase in complex with clofarabine reveals key interactions for prodrug activation .
12604186	0	clofibrate	52,62	Aldehyde_dehydrogenase_3	0,24	clofibrate	Aldehyde dehydrogenase 3	MESH:D002994	25375(Tax:10116)	Chemical	Gene	decreased|nmod|START_ENTITY decreased|nsubjpass|expression expression|amod|END_ENTITY	Aldehyde_dehydrogenase_3 expression is decreased by clofibrate via PPAR_gamma induction in JM2 rat hepatoma cell line .
7103935	0	clofibrate	30,40	Cytochrome_P-450	0,16	clofibrate	Cytochrome P-450	MESH:D002994	25251(Tax:10116)	Chemical	Gene	induction|nmod|START_ENTITY induction|nsubj|END_ENTITY	Cytochrome_P-450 induction by clofibrate .
16540100	0	clofibrate	58,68	Peroxisome_proliferator-activated_receptor_alpha	0,48	clofibrate	Peroxisome proliferator-activated receptor alpha	MESH:D002994	25747(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Peroxisome_proliferator-activated_receptor_alpha agonist , clofibrate , has profound influence on myocardial fatty_acid composition .
6796058	0	clofibrate	44,54	carnitine_acetyltransferase	13,40	clofibrate	carnitine acetyltransferase	MESH:D002994	311849(Tax:10116)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of carnitine_acetyltransferase by clofibrate in rat liver .
193524	0	clofibrate	20,30	familial_hypercholesterolemia	34,63	clofibrate	familial hypercholesterolemia	MESH:D002994	3949	Chemical	Gene	Pharmacokinetics|nmod|START_ENTITY Pharmacokinetics|nmod|END_ENTITY	Pharmacokinetics of clofibrate in familial_hypercholesterolemia .
1008908	0	clofibrate	11,21	insulin	52,59	clofibrate	insulin	MESH:D002994	3630	Chemical	Gene	treatment|amod|START_ENTITY Effects|nmod|treatment Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of clofibrate treatment on arginine-induced insulin secretion in endogenous_hypertriglyceridemia .
1020607	0	clofibrate	21,31	insulin	52,59	clofibrate	insulin	MESH:D002994	3630	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|compound|END_ENTITY	Inhibitory effect of clofibrate on arginine-induced insulin secretion in chemical diabetes .
736705	0	clofibrate	42,52	insulin	56,63	clofibrate	insulin	MESH:D002994	3630	Chemical	Gene	START_ENTITY|nmod|response response|compound|END_ENTITY	Influence of short-term administration of clofibrate on insulin and glucagon response to protein ingestion in man .
5111329	0	clofibrate	10,20	lipoprotein_lipase	24,42	clofibrate	lipoprotein lipase	MESH:D002994	4023	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of clofibrate on lipoprotein_lipase .
21102658	0	clofibrate	61,71	liver_fatty_acid_binding_protein	14,46	clofibrate	liver fatty acid binding protein	MESH:D002994	2168	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of liver_fatty_acid_binding_protein expression by clofibrate in hepatoma cells .
16257849	0	clofibrate	44,54	p53	62,65	clofibrate	p53	MESH:D002994	22060(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Evaluation of the carcinogenic potential of clofibrate in the p53 + / - mouse .
25883783	0	clofibrate	132,142	peroxisome_proliferator-activated_receptor_alpha	75,123	clofibrate	peroxisome proliferator-activated receptor alpha	MESH:D002994	397239(Tax:9823)	Chemical	Gene	START_ENTITY|nsubj|induction induction|nmod|oxidation oxidation|nmod|pigs pigs|nmod|agonist agonist|amod|END_ENTITY	Transplacental induction of fatty_acid oxidation in term fetal pigs by the peroxisome_proliferator-activated_receptor_alpha agonist clofibrate .
26621841	0	clofibrate	82,92	peroxisome_proliferator-activated_receptor_alpha	18,66	clofibrate	peroxisome proliferator-activated receptor alpha	MESH:D002994	5465	Chemical	Gene	ligand|dobj|START_ENTITY ligand|nsubj|Implications Implications|nmod|END_ENTITY	Implications of a peroxisome_proliferator-activated_receptor_alpha -LRB- PPARa -RRB- ligand clofibrate in breast_cancer .
23432317	0	clofibric_acid	59,73	PPARa	77,82	clofibric acid	PPARa	MESH:D002995	5465	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Effect of stilbene and chalcone scaffolds incorporation in clofibric_acid on PPARa agonistic activity .
19791744	0	clofibric_acid	82,96	peroxisome_proliferator-activated_receptor_alpha	100,148	clofibric acid	peroxisome proliferator-activated receptor alpha	MESH:D002995	5465	Chemical	Gene	START_ENTITY|nmod|agonists agonists|amod|END_ENTITY	Synthesis and biological evaluation of 2-heteroarylthioalkanoic_acid analogues of clofibric_acid as peroxisome_proliferator-activated_receptor_alpha agonists .
9094202	0	clofibric_acid	34,48	peroxisome_proliferator-activated_receptor_alpha	64,112	clofibric acid	peroxisome proliferator-activated receptor alpha	MESH:D002995	25747(Tax:10116)	Chemical	Gene	analogs|amod|START_ENTITY analogs|nmod|END_ENTITY	Stereoselective effects of chiral clofibric_acid analogs on rat peroxisome_proliferator-activated_receptor_alpha -LRB- rPPAR_alpha -RRB- activation and peroxisomal fatty_acid beta-oxidation .
15717648	0	clomiphene	25,35	leptin	47,53	clomiphene	leptin	MESH:D002996	3952	Chemical	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Gonadotropin response to clomiphene and plasma leptin levels in weight recovered but amenorrhoeic patients with anorexia_nervosa .
3114297	0	clomiphene	109,119	prolactin	75,84	clomiphene	prolactin	MESH:D002996	5617	Chemical	Gene	administration|nmod|START_ENTITY END_ENTITY|nmod|administration	Oocyte maturity and human follicular fluid prostanoids , gonadotropins , and prolactin after administration of clomiphene and pergonal .
336077	0	clomiphene	10,20	prolactin	24,33	clomiphene	prolactin	MESH:D002996	5617	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of clomiphene on prolactin secretion and lactation in puerperal women .
9661617	0	clomiphene_citrate	53,71	insulin-like_growth_factor_I	11,39	clomiphene citrate	insulin-like growth factor I	MESH:D002996	3479	Chemical	Gene	levels|nmod|START_ENTITY levels|amod|END_ENTITY	Decline in insulin-like_growth_factor_I levels after clomiphene_citrate does not correct hyperandrogenemia in polycystic_ovary_syndrome .
348501	0	clomiphene_citrate	10,28	luteinizing_hormone-releasing_hormone	64,101	clomiphene citrate	luteinizing hormone-releasing hormone	MESH:D002996	2796	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|nmod|END_ENTITY	Effect of clomiphene_citrate on plasma levels of immunoreactive luteinizing_hormone-releasing_hormone , gonadotropin , and testosterone in normal subjects and in patients with idiopathic oligospermia .
1757515	0	clomiphene_citrate	10,28	pregnancy_associated_endometrial_alpha_2-globulin	101,150	clomiphene citrate	pregnancy associated endometrial alpha 2-globulin	MESH:D002996	5047	Chemical	Gene	Effect|nmod|START_ENTITY Effect|amod|END_ENTITY	Effect of clomiphene_citrate on the synthesis and release of the human beta-lactoglobulin homologue , pregnancy_associated_endometrial_alpha_2-globulin , by the uterine endometrium .
1247048	0	clomiphene_citrate	10,28	prolactin	38,47	clomiphene citrate	prolactin	MESH:D002996	5617	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of clomiphene_citrate on serum prolactin in infertile women with ovarian_dysfunction .
6797955	0	clomiphene_citrate	14,32	sex_hormone_binding_globulin	36,64	clomiphene citrate	sex hormone binding globulin	MESH:D002996	6462	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of clomiphene_citrate on sex_hormone_binding_globulin in normospermic and oligozoospermic men .
21336575	0	clomipramine	17,29	NET	0,3	clomipramine	NET	MESH:D002997	6530	Chemical	Gene	occupancy|nmod|START_ENTITY occupancy|nsubj|END_ENTITY	NET occupancy by clomipramine and its active metabolite , desmethylclomipramine , in non-human primates in vivo .
12084414	0	clomipramine	29,41	Prolactin	0,9	clomipramine	Prolactin	MESH:D002997	5617	Chemical	Gene	responses|nmod|START_ENTITY responses|compound|END_ENTITY	Prolactin responses to acute clomipramine and haloperidol of male schizophrenic patients in a drug-free state and after treatment with clozapine or with olanzapine .
21178381	0	clomipramine	54,66	Prolactin	0,9	clomipramine	Prolactin	MESH:D002997	5617	Chemical	Gene	challenge|compound|START_ENTITY responses|nmod|challenge responses|compound|END_ENTITY	Prolactin and cortisol responses to acute intravenous clomipramine challenge in patients with mania , depression and healthy controls : evidence for reduced_serotonergic_responsivity .
2780783	0	clomipramine	23,35	prolactin	102,111	clomipramine	prolactin	MESH:D002997	24683(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY effect|nmod|treatment effect|nmod|increases increases|nmod|END_ENTITY	Differential effect of clomipramine treatment on m-chlorophenylpiperazine-induced increases in plasma prolactin and corticosterone in rats .
8110915	0	clomipramine	30,42	prolactin	8,17	clomipramine	prolactin	MESH:D002997	5617	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Altered prolactin response to clomipramine rechallenge in healthy subjects .
12695316	0	clomipramine	61,73	serotonin_transporter	15,36	clomipramine	serotonin transporter	MESH:D002997	6532	Chemical	Gene	occupancy|nmod|START_ENTITY occupancy|compound|END_ENTITY	High levels of serotonin_transporter occupancy with low-dose clomipramine in comparative occupancy study with fluvoxamine using positron emission tomography .
2455172	0	clonidine	11,20	ANF	49,52	clonidine	ANF	MESH:D003000	4878	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of clonidine and dihydralazine on plasma ANF and cyclic_GMP levels in humans during volume loading .
10414671	0	clonidine	11,20	CO2	87,90	clonidine	CO2	MESH:D003000	717	Chemical	Gene	Effects|nmod|START_ENTITY flow|nsubj|Effects flow|dobj|response response|compound|END_ENTITY	Effects of clonidine on human middle cerebral artery flow velocity and cerebrovascular CO2 response during sevoflurane anesthesia .
3011828	0	clonidine	11,20	CO2	73,76	clonidine	CO2	MESH:D003000	717	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of clonidine on cerebral blood flow and the response to arterial CO2 .
9549742	0	clonidine	38,47	CO2	15,18	clonidine	CO2	MESH:D003000	717	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|dobj|effects	Transcutaneous CO2 tension effects of clonidine in paediatric caudal_analgesia .
22474555	0	clonidine	11,20	EAAT3	70,75	clonidine	EAAT3	MESH:D003000	25550(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	Effects of clonidine on the activity of the rat glutamate transporter EAAT3 expressed in Xenopus oocytes .
1398465	0	clonidine	22,31	GH	52,54	clonidine	GH	MESH:D003000	2688	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Comparative effect of clonidine and growth_hormone -LRB- GH -RRB- - releasing hormone on GH secretion in adult patients on chronic glucocorticoid therapy .
1398465	0	clonidine	22,31	GH	77,79	clonidine	GH	MESH:D003000	2688	Chemical	Gene	effect|nmod|START_ENTITY effect|parataxis|releasing releasing|nmod|secretion secretion|compound|END_ENTITY	Comparative effect of clonidine and growth_hormone -LRB- GH -RRB- - releasing hormone on GH secretion in adult patients on chronic glucocorticoid therapy .
1398465	5	clonidine	850,859	GH	926,928	clonidine	GH	MESH:D003000	2688	Chemical	Gene	responses|nmod|START_ENTITY blunted|nsubjpass|responses blunted|nmod|patients patients|dep|/ /|compound|END_ENTITY	The GH responses to clonidine were also blunted -LRB- p less than 0.05 -RRB- in steroid-treated patients -LRB- GH peak 5.8 + / - 2.8 micrograms/L -RRB- with respect to normal subjects -LRB- GH peak 17.6 + / - 2.3 micrograms/L -RRB- .
1610485	0	clonidine	115,124	GH	98,100	clonidine	GH	MESH:D003000	2688	Chemical	Gene	profile|nmod|START_ENTITY profile|nmod|responses responses|appos|END_ENTITY	Evidence for hypothalamo-growth_hormone dysfunction in panic_disorder : profile of growth_hormone -LRB- GH -RRB- responses to clonidine , yohimbine , caffeine , glucose , GRF and TRH in panic_disorder patients versus healthy volunteers .
2087535	0	clonidine	32,41	GH	16,18	clonidine	GH	MESH:D003000	2688	Chemical	Gene	response|xcomp|START_ENTITY response|nsubj|Growth_hormone Growth_hormone|appos|END_ENTITY	Growth_hormone -LRB- GH -RRB- response to clonidine and growth_hormone_releasing_factor -LRB- GRF -RRB- in normal controls .
2536561	0	clonidine	69,78	GH	54,56	clonidine	GH	MESH:D003000	2688	Chemical	Gene	response|acl|START_ENTITY response|amod|END_ENTITY	Alpha 2-adrenoceptor sensitivity in anorexia_nervosa : GH response to clonidine or GHRH stimulation .
26874268	0	clonidine	27,36	GH	0,2	clonidine	GH	MESH:D003000	2688	Chemical	Gene	challenge|compound|START_ENTITY response|nmod|challenge response|compound|END_ENTITY	GH response to intravenous clonidine challenge correlates with history of childhood trauma in personality_disorder .
3082919	0	clonidine	51,60	GH	35,37	clonidine	GH	MESH:D003000	2688	Chemical	Gene	hormone|compound|START_ENTITY Suppression|nmod|hormone Suppression|nmod|response response|appos|END_ENTITY	Suppression of the growth_hormone -LRB- GH -RRB- response to clonidine and GH-releasing hormone by exogenous GH .
3082919	0	clonidine	51,60	GH	99,101	clonidine	GH	MESH:D003000	2688	Chemical	Gene	hormone|compound|START_ENTITY Suppression|nmod|hormone Suppression|nmod|END_ENTITY	Suppression of the growth_hormone -LRB- GH -RRB- response to clonidine and GH-releasing hormone by exogenous GH .
3139739	0	clonidine	47,56	GH	26,28	clonidine	GH	MESH:D003000	2688	Chemical	Gene	response|nmod|START_ENTITY response|amod|growth_hormone growth_hormone|dep|END_ENTITY	Decreased growth_hormone -LRB- GH -RRB- response to oral clonidine in endemic cretinism : effect of L-T3 therapy .
3141943	0	clonidine	107,116	GH	16,18	clonidine	GH	MESH:D003000	2688	Chemical	Gene	correlation|nmod|START_ENTITY Growth_hormone|dobj|correlation Growth_hormone|dobj|responses responses|appos|END_ENTITY	Growth_hormone -LRB- GH -RRB- responses to GH-releasing hormone in depression : correlation with GH release following clonidine .
3141943	0	clonidine	107,116	GH	86,88	clonidine	GH	MESH:D003000	2688	Chemical	Gene	correlation|nmod|START_ENTITY correlation|nmod|release release|compound|END_ENTITY	Growth_hormone -LRB- GH -RRB- responses to GH-releasing hormone in depression : correlation with GH release following clonidine .
6545412	0	clonidine	19,28	GH	4,6	clonidine	GH	MESH:D003000	2688	Chemical	Gene	response|acl|START_ENTITY response|compound|END_ENTITY	The GH response to clonidine in endogenous as compared with reactive depression .
7283286	3	clonidine	606,615	GH	588,590	clonidine	GH	MESH:D003000	2688	Chemical	Gene	increase|advcl|START_ENTITY increase|dobj|END_ENTITY	In two children with short_stature without endocrinological disturb , there was a partial failure to increase GH in response to clonidine .
8531260	0	clonidine	105,114	GH	28,30	clonidine	GH	MESH:D003000	2688	Chemical	Gene	GH|advcl|START_ENTITY GH|nsubj|growth_hormone growth_hormone|appos|END_ENTITY	Circulating growth_hormone -LRB- GH -RRB- , insulin-like growth factor-I -LRB- IGF-I -RRB- and free thyroxine , GH response to clonidine provocation and CT scanning of the hypothalamic-pituitary area in children with sickle_cell_disease .
8606442	0	clonidine	59,68	GH	26,28	clonidine	GH	MESH:D003000	2688	Chemical	Gene	response|acl|START_ENTITY secretion|dobj|response secretion|nsubj|growth_hormone growth_hormone|appos|END_ENTITY	Nocturnal growth_hormone -LRB- GH -RRB- secretion and GH response to clonidine provocation in children before and after long-term prednisone therapy .
8816035	0	clonidine	51,60	GH	35,37	clonidine	GH	MESH:D003000	2688	Chemical	Gene	insulin-like_growth_factor-I|amod|START_ENTITY response|dep|insulin-like_growth_factor-I response|appos|END_ENTITY	Growth parameters , growth_hormone -LRB- GH -RRB- response to clonidine and circulating insulin-like_growth_factor-I -LRB- IGF-I -RRB- , free thyroxine -LRB- FT4 -RRB- and cortisol concentrations in relation to glycaemic control in children with insulin-dependent_diabetes_mellitus .
8918979	0	clonidine	93,102	GH	122,124	clonidine	GH	MESH:D003000	81668(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY recovery|nmod|effect influences|dobj|recovery influences|nmod|secretion secretion|appos|END_ENTITY	The pattern of testosterone replacement influences the recovery of the stimulatory effect of clonidine on growth_hormone -LRB- GH -RRB- secretion in orchidectomized rats .
7568369	0	clonidine	27,36	Growth-hormone	0,14	clonidine	Growth-hormone	MESH:D003000	2688	Chemical	Gene	START_ENTITY|nsubj|response response|amod|END_ENTITY	Growth-hormone response to clonidine in panic_disorder patients in comparison to patients with major_depression and healthy controls .
10963795	0	clonidine	27,36	Growth_hormone	0,14	clonidine	Growth hormone	MESH:D003000	2688	Chemical	Gene	response|acl|START_ENTITY response|amod|END_ENTITY	Growth_hormone response to clonidine in adversely reared young adult primates : relationship to serial cerebrospinal fluid corticotropin-releasing_factor concentrations .
11795657	0	clonidine	45,54	Growth_hormone	0,14	clonidine	Growth hormone	MESH:D003000	2688	Chemical	Gene	testing|nmod|START_ENTITY testing|amod|END_ENTITY	Growth_hormone stimulation testing with oral clonidine : 90 minutes is the preferred duration for the assessment of growth_hormone reserve .
15219643	0	clonidine	27,36	Growth_hormone	0,14	clonidine	Growth hormone	MESH:D003000	2688	Chemical	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Growth_hormone response to clonidine predicts aggression in Alzheimer 's _ disease .
1652141	0	clonidine	47,56	Growth_hormone	0,14	clonidine	Growth hormone	MESH:D003000	2688	Chemical	Gene	responses|xcomp|START_ENTITY responses|nsubj|END_ENTITY	Growth_hormone and other hormonal responses to clonidine in melancholic and nonmelancholic depressed subjects and controls .
1665918	0	clonidine	40,49	Growth_hormone	0,14	clonidine	Growth hormone	MESH:D003000	2688	Chemical	Gene	challenge|compound|START_ENTITY responses|nmod|challenge responses|amod|END_ENTITY	Growth_hormone responses to intravenous clonidine challenge correlate with behavioral irritability in psychiatric patients and healthy volunteers .
18445981	0	clonidine	95,104	Growth_hormone	0,14	clonidine	Growth hormone	MESH:D003000	2688	Chemical	Gene	test|amod|START_ENTITY usefulness|nmod|test short_stature|dep|usefulness short_stature|amod|END_ENTITY	Growth_hormone deficiency short_stature in a third world adult endocrine clinic : usefulness of clonidine test in its diagnosis .
2087535	0	clonidine	32,41	Growth_hormone	0,14	clonidine	Growth hormone	MESH:D003000	2688	Chemical	Gene	response|xcomp|START_ENTITY response|nsubj|END_ENTITY	Growth_hormone -LRB- GH -RRB- response to clonidine and growth_hormone_releasing_factor -LRB- GRF -RRB- in normal controls .
3023778	0	clonidine	28,37	Growth_hormone	0,14	clonidine	Growth hormone	MESH:D003000	81668(Tax:10116)	Chemical	Gene	responses|acl|START_ENTITY responses|amod|END_ENTITY	Growth_hormone responses to clonidine and GRF in spontaneously hypertensive rats : neuroendocrine evidence for an enhanced responsiveness of brain alpha 2-adrenoceptors in genetical hypertension .
3141943	0	clonidine	107,116	Growth_hormone	0,14	clonidine	Growth hormone	MESH:D003000	2688	Chemical	Gene	correlation|nmod|START_ENTITY END_ENTITY|dobj|correlation	Growth_hormone -LRB- GH -RRB- responses to GH-releasing hormone in depression : correlation with GH release following clonidine .
6392861	0	clonidine	92,101	Growth_hormone	1,15	clonidine	Growth hormone	MESH:D003000	2688	Chemical	Gene	-RSB-|amod|START_ENTITY administration|nmod|-RSB- children|nmod|administration activity|nmod|children END_ENTITY|dobj|activity	-LSB- Growth_hormone secretion and plasma renin activity in children following administration of clonidine -RSB- .
6398141	0	clonidine	27,36	Growth_hormone	0,14	clonidine	Growth hormone	MESH:D003000	2688	Chemical	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Growth_hormone response to clonidine is impaired in patients with central sympathetic degeneration .
7217341	0	clonidine	64,73	Growth_hormone	0,14	clonidine	Growth hormone	MESH:D003000	2688	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|release release|amod|END_ENTITY	Growth_hormone release in hypertensive adolescents treated with clonidine .
7272645	0	clonidine	38,47	Growth_hormone	0,14	clonidine	Growth hormone	MESH:D003000	2688	Chemical	Gene	START_ENTITY|nsubj|responses responses|amod|END_ENTITY	Growth_hormone and other responses to clonidine in patients with endogenous_depression .
7584524	0	clonidine	139,148	Growth_hormone	0,14	clonidine	Growth hormone	MESH:D003000	2688	Chemical	Gene	comparison|acl|START_ENTITY secretion|dep|comparison secretion|amod|END_ENTITY	Growth_hormone secretion in response to the new centrally acting antihypertensive agent moxonidine in normal human subjects : comparison to clonidine and GHRH .
8027274	0	clonidine	121,130	Growth_hormone	0,14	clonidine	Growth hormone	MESH:D003000	2688	Chemical	Gene	negative|amod|START_ENTITY patients|amod|negative conception|nmod|patients enhance|dobj|conception enhance|nsubj|co-treatment co-treatment|amod|END_ENTITY	Growth_hormone co-treatment for ovulation induction may enhance conception in the co-treatment and succeeding cycles , in clonidine negative but not clonidine positive patients .
8144867	0	clonidine	32,41	Growth_hormone	0,14	clonidine	Growth hormone	MESH:D003000	2688	Chemical	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Growth_hormone response to oral clonidine test in normal and short children .
8292687	0	clonidine	39,48	Growth_hormone	0,14	clonidine	Growth hormone	MESH:D003000	2688	Chemical	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Growth_hormone response to intravenous clonidine in social_phobia : comparison to patients with panic_disorder and healthy volunteers .
8416019	0	clonidine	27,36	Growth_hormone	0,14	clonidine	Growth hormone	MESH:D003000	2688	Chemical	Gene	response|acl|START_ENTITY response|amod|END_ENTITY	Growth_hormone response to clonidine in neuroleptic-free patients with multidagnostically defined schizophrenia .
8852865	0	clonidine	27,36	Growth_hormone	0,14	clonidine	Growth hormone	MESH:D003000	2688	Chemical	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Growth_hormone response to clonidine and the cortisol response to dexamethasone in depressive patients .
9109183	0	clonidine	100,109	Growth_hormone	73,87	clonidine	Growth hormone	MESH:D003000	2688	Chemical	Gene	stimulation|amod|START_ENTITY response|nmod|stimulation response|compound|END_ENTITY	Noradrenergic receptor sensitivity in obsessive-compulsive_disorders : I. Growth_hormone response to clonidine stimulation .
2548222	0	clonidine	14,23	P300	36,40	clonidine	P300	MESH:D003000	2033	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of clonidine on auditory P300 .
727216	0	clonidine	25,34	Renin	0,5	clonidine	Renin	MESH:D003000	5972	Chemical	Gene	therapy|amod|START_ENTITY stimulation|nmod|therapy stimulation|nsubj|END_ENTITY	Renin stimulation during clonidine therapy in `` low renin '' essential hypertension .
998518	0	clonidine	68,77	Renin	0,5	clonidine	Renin	MESH:D003000	5972	Chemical	Gene	suppression|nmod|START_ENTITY suppression|compound|END_ENTITY	Renin and aldosterone suppression in the antihypertensive action of clonidine .
6150856	0	clonidine	100,109	S3341	48,53	clonidine	S3341	MESH:D003000	1079580(Tax:198215)	Chemical	Gene	studies|nmod|START_ENTITY studies|nmod|END_ENTITY	Preliminary clinical pharmacological studies of S3341 , a new hypotensive agent , and comparison with clonidine in normal males .
19011889	0	clonidine	14,23	VEGF	27,31	clonidine	VEGF	MESH:D003000	7422	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	The effect of clonidine on VEGF expression in human retinal pigment epithelial cells -LRB- ARPE-19 -RRB- .
1836674	0	clonidine	30,39	atrial_natriuretic_factor	74,99	clonidine	atrial natriuretic factor	MESH:D003000	24602(Tax:10116)	Chemical	Gene	solitarii|amod|START_ENTITY solitarii|nmod|END_ENTITY	-LSB- Effects of microinjection of clonidine into nucleus tractus solitarii on atrial_natriuretic_factor in rats -RSB- .
2551880	0	clonidine	11,20	atrial_natriuretic_factor	42,67	clonidine	atrial natriuretic factor	MESH:D003000	4878	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of clonidine and dihydralazine on atrial_natriuretic_factor and cGMP in humans .
7901963	0	clonidine	100,109	atrial_natriuretic_factor	25,50	clonidine	atrial natriuretic factor	MESH:D003000	4878	Chemical	Gene	mechanism|nmod|START_ENTITY END_ENTITY|nmod|mechanism	-LSB- Possible involvement of atrial_natriuretic_factor and vasopressin in antihypertensive mechanism of clonidine in humans -RSB- .
9152372	0	clonidine	25,34	atrial_natriuretic_factor	64,89	clonidine	atrial natriuretic factor	MESH:D003000	24602(Tax:10116)	Chemical	Gene	ST-91|amod|START_ENTITY action|nmod|ST-91 action|dep|involvement involvement|nmod|END_ENTITY	The peripheral action of clonidine analog ST-91 : involvement of atrial_natriuretic_factor .
2140250	0	clonidine	25,34	beta-endorphin	61,75	clonidine	beta-endorphin	MESH:D003000	5443	Chemical	Gene	START_ENTITY|nmod|responses responses|compound|END_ENTITY	Effects of intramuscular clonidine on hemodynamic and plasma beta-endorphin responses to gynecologic laparoscopy .
2931400	0	clonidine	10,19	beta-endorphin	30,44	clonidine	beta-endorphin	MESH:D003000	5443	Chemical	Gene	secretion|amod|START_ENTITY secretion|amod|END_ENTITY	Effect of clonidine on plasma beta-endorphin , cortisol and growth_hormone secretion in opiate-addicted subjects .
8938679	0	clonidine	65,74	erythropoietin	92,106	clonidine	erythropoietin	MESH:D003000	2056	Chemical	Gene	START_ENTITY|nmod|therapy therapy|compound|END_ENTITY	Growth_hormone responses to growth_hormone-releasing_hormone and clonidine before and after erythropoietin therapy in CAPD patients .
12242540	0	clonidine	43,52	growth-hormone	15,29	clonidine	growth-hormone	MESH:D003000	2688	Chemical	Gene	release|nmod|START_ENTITY release|amod|END_ENTITY	Stimulation of growth-hormone release with clonidine does not distinguish individual cases of idiopathic_Parkinson 's _ disease from those with striatonigral_degeneration .
10218537	0	clonidine	15,24	growth_hormone	25,39	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	stimulation|amod|START_ENTITY stimulation|compound|END_ENTITY	Failure of the clonidine growth_hormone stimulation test to differentiate multiple_system_atrophy from early or advanced idiopathic_Parkinson 's _ disease .
11151417	0	clonidine	3,12	growth_hormone	13,27	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	stimulation|amod|START_ENTITY stimulation|compound|END_ENTITY	Is clonidine growth_hormone stimulation a good test to differentiate multiple_system_atrophy from idiopathic_Parkinson 's _ disease ?
11472079	0	clonidine	64,73	growth_hormone	24,38	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	START_ENTITY|nsubj|responses responses|compound|END_ENTITY	Age - and gender-related growth_hormone responses to intravenous clonidine in healthy adults .
11795657	0	clonidine	45,54	growth_hormone	115,129	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	testing|nmod|START_ENTITY testing|dep|minutes minutes|acl:relcl|duration duration|nmod|assessment assessment|nmod|reserve reserve|amod|END_ENTITY	Growth_hormone stimulation testing with oral clonidine : 90 minutes is the preferred duration for the assessment of growth_hormone reserve .
1184719	0	clonidine	10,19	growth_hormone	23,37	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of clonidine on growth_hormone , prolactin , luteinizing hormone , follicle-stimulating hormone , and thyroid-stimulating hormone in the serum of normal men .
1599607	0	clonidine	31,40	growth_hormone	4,18	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	START_ENTITY|nsubj|response response|amod|END_ENTITY	The growth_hormone response to clonidine in acute and remitted depressed male patients .
1610485	0	clonidine	115,124	growth_hormone	82,96	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	profile|nmod|START_ENTITY profile|nmod|responses responses|amod|END_ENTITY	Evidence for hypothalamo-growth_hormone dysfunction in panic_disorder : profile of growth_hormone -LRB- GH -RRB- responses to clonidine , yohimbine , caffeine , glucose , GRF and TRH in panic_disorder patients versus healthy volunteers .
16974105	0	clonidine	5,14	growth_hormone	52,66	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	test|amod|START_ENTITY test|nmod|diagnosis diagnosis|nmod|deficiency deficiency|amod|END_ENTITY	Oral clonidine provocative test in the diagnosis of growth_hormone deficiency in childhood : should we make the timing uniform ?
17889730	0	clonidine	54,63	growth_hormone	22,36	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	hydration|nmod|START_ENTITY hydration|nmod|stimulation stimulation|amod|END_ENTITY	Oral hydration during growth_hormone stimulation with clonidine .
1823078	0	clonidine	17,26	growth_hormone	67,81	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|secretion secretion|amod|END_ENTITY	Acute effects of clonidine and growth-hormone-releasing_hormone on growth_hormone secretion in patients with hyperthyroidism .
18540253	0	clonidine	46,55	growth_hormone	88,102	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	START_ENTITY|nmod|evaluation evaluation|nmod|status status|amod|END_ENTITY	Is testosterone and estrogen priming prior to clonidine useful in the evaluation of the growth_hormone status of short peripubertal children ?
19028836	0	clonidine	84,93	growth_hormone	57,71	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	response|acl|START_ENTITY response|amod|END_ENTITY	Noradrenergic function in pathological gambling : blunted growth_hormone response to clonidine .
20405138	0	clonidine	18,27	growth_hormone	59,73	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	comparison|nmod|START_ENTITY combined|nsubj|comparison combined|dobj|test test|amod|END_ENTITY	The comparison of clonidine , arginine and both combined : a growth_hormone stimulation test to differentiate multiple system atrophy from idiopathic_Parkinson 's _ disease .
2092912	0	clonidine	85,94	growth_hormone	132,146	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	test|amod|START_ENTITY test|nmod|diagnosis diagnosis|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Efficient diagnosis of hypothalamo-hypophyseal_nanism : 5 years ' experience with the clonidine stimulation test in the diagnosis of growth_hormone secretion -RSB- .
2100275	0	clonidine	18,27	growth_hormone	49,63	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	treatment|compound|START_ENTITY Effect|nmod|treatment END_ENTITY|nsubj|Effect	Effect of chronic clonidine treatment on urinary growth_hormone excretion and linear growth in children with short_stature .
2106450	0	clonidine	35,44	growth_hormone	4,18	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	administration|amod|START_ENTITY increase|nmod|administration increase|nsubj|END_ENTITY	Can growth_hormone increase , after clonidine administration , predict the dose of human menopausal hormone needed for induction of ovulation ?
21349805	0	clonidine	51,60	growth_hormone	110,124	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	test|amod|START_ENTITY levels|nmod|test END_ENTITY|nsubj|levels	Ghrelin and growth_hormone serum levels during the clonidine test in children with short_stature and variable growth_hormone status .
2147600	0	clonidine	24,33	growth_hormone	93,107	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|stimulation stimulation|nmod|secretion secretion|amod|END_ENTITY	The interaction between clonidine and growth_hormone_releasing_hormone in the stimulation of growth_hormone secretion in man .
21521260	0	clonidine	60,69	growth_hormone	33,47	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	Effect|acl|START_ENTITY Effect|nmod|index index|nmod|response response|amod|END_ENTITY	Effect of body mass index on the growth_hormone response to clonidine stimulation testing in children with short_stature .
2154719	0	clonidine	185,194	growth_hormone	40,54	clonidine	growth hormone	MESH:D003000	81668(Tax:10116)	Chemical	Gene	mechanisms|nmod|START_ENTITY testosterone|nmod|mechanisms role|nmod|testosterone Loss|dep|role Loss|nmod|effects effects|nmod|clonidine clonidine|nmod|release release|amod|END_ENTITY	Loss of the effects of clonidine on the growth_hormone release and hypotensive action in long-term castrated rats : the possible role of testosterone on alpha-2-adrenergic mechanisms of clonidine .
2154719	0	clonidine	23,32	growth_hormone	40,54	clonidine	growth hormone	MESH:D003000	81668(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|release release|amod|END_ENTITY	Loss of the effects of clonidine on the growth_hormone release and hypotensive action in long-term castrated rats : the possible role of testosterone on alpha-2-adrenergic mechanisms of clonidine .
2162745	0	clonidine	132,141	growth_hormone	53,67	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	administration|compound|START_ENTITY receiving|dobj|administration involved|xcomp|receiving involved|nmod|control control|amod|END_ENTITY	Down-regulation of alpha 2-adrenoceptors involved in growth_hormone control in the hypothalamus of infant rats receiving short-term clonidine administration .
2204433	0	clonidine	44,53	growth_hormone	14,28	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	hypoglycemia|compound|START_ENTITY Comparison|nmod|hypoglycemia Comparison|nmod|response response|amod|END_ENTITY	Comparison of growth_hormone response after clonidine and insulin hypoglycemia in affective illness .
2301821	0	clonidine	20,29	growth_hormone	51,65	clonidine	growth hormone	MESH:D003000	403795(Tax:9615)	Chemical	Gene	START_ENTITY|nmod|secretagogue secretagogue|nmod|END_ENTITY	Orally administered clonidine as a secretagogue of growth_hormone and as a thymotrophic agent in dogs of various ages .
2333361	0	clonidine	70,79	growth_hormone	33,47	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	challenge|amod|START_ENTITY END_ENTITY|nmod|challenge	Dose-response profiles of plasma growth_hormone and vasopressin after clonidine challenge in man .
23795255	0	clonidine	62,71	growth_hormone	76,90	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	START_ENTITY|nmod|deficiency deficiency|amod|END_ENTITY	Diagnostic value of provocative test by insulin combined with clonidine for growth_hormone deficiency in children .
2543999	0	clonidine	53,62	growth_hormone	26,40	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	Effect|acl|START_ENTITY Effect|nmod|naloxone naloxone|nmod|response response|amod|END_ENTITY	Effect of naloxone on the growth_hormone response to clonidine in normal women during the mid-luteal phase .
2612023	0	clonidine	76,85	growth_hormone	49,63	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	response|acl|START_ENTITY response|amod|END_ENTITY	Impairment of modulating role of testosterone in growth_hormone response to clonidine in essential_hypertension .
26630691	0	clonidine	23,32	growth_hormone	55,69	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	START_ENTITY|nmod|deficiency deficiency|amod|END_ENTITY	The shortened combined clonidine and arginine test for growth_hormone deficiency is practical and specific : a diagnostic accuracy study .
2698383	0	clonidine	5,14	growth_hormone	29,43	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	START_ENTITY|dep|test test|amod|END_ENTITY	Oral clonidine : an effective growth_hormone provocative test .
2884230	0	clonidine	82,91	growth_hormone	26,40	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|estrogen estrogen|nmod|response response|amod|END_ENTITY	Effect of estrogen on the growth_hormone response to the alpha-adrenergic agonist clonidine in women with menopausal_flushing .
2918053	0	clonidine	100,109	growth_hormone	16,30	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	administration|compound|START_ENTITY constitutional_growth_delay|nmod|administration children|nmod|constitutional_growth_delay secretion|nmod|children secretion|amod|END_ENTITY	Augmentation of growth_hormone secretion in children with constitutional_growth_delay by short term clonidine administration : a pulse amplitude-modulated phenomenon .
2989759	0	clonidine	136,145	growth_hormone	40,54	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	infusion|amod|START_ENTITY response|nmod|infusion reversal|nmod|response regulation|dep|reversal regulation|nmod|secretion secretion|amod|END_ENTITY	Deranged alpha-adrenergic regulation of growth_hormone secretion in poorly controlled diabetes : reversal of the exaggerated response to clonidine after continuous subcutaneous insulin infusion .
3035083	0	clonidine	57,66	growth_hormone	30,44	clonidine	growth hormone	MESH:D003000	81668(Tax:10116)	Chemical	Gene	influence|xcomp|START_ENTITY influence|nmod|response response|amod|END_ENTITY	Serotonergic influence on the growth_hormone response to clonidine in rat .
3082919	0	clonidine	51,60	growth_hormone	19,33	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	hormone|compound|START_ENTITY Suppression|nmod|hormone Suppression|nmod|response response|amod|END_ENTITY	Suppression of the growth_hormone -LRB- GH -RRB- response to clonidine and GH-releasing hormone by exogenous GH .
3095519	0	clonidine	20,29	growth_hormone	48,62	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	administration|amod|START_ENTITY administration|nmod|concentrations concentrations|amod|END_ENTITY	Effect of prolonged clonidine administration on growth_hormone concentrations and rate of linear growth in children with constitutional growth delay .
3104956	0	clonidine	37,46	growth_hormone	10,24	clonidine	growth hormone	MESH:D003000	81668(Tax:10116)	Chemical	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Increased growth_hormone response to clonidine in 6-hydroxydopamine-treated rats .
3126262	0	clonidine	55,64	growth_hormone	27,41	clonidine	growth hormone	MESH:D003000	81668(Tax:10116)	Chemical	Gene	Effects|acl|START_ENTITY Effects|nmod|steroids steroids|nmod|responses responses|amod|END_ENTITY	Effects of sex steroids on growth_hormone responses to clonidine and GHRH in reserpine pretreated rats .
3139739	0	clonidine	47,56	growth_hormone	10,24	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Decreased growth_hormone -LRB- GH -RRB- response to oral clonidine in endemic cretinism : effect of L-T3 therapy .
3224252	0	clonidine	38,47	growth_hormone	20,34	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	response|acl|START_ENTITY response|nmod|END_ENTITY	Blunted response of growth_hormone to clonidine and apomorphine in endogenous_depression .
3717403	0	clonidine	37,46	growth_hormone	10,24	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	The human growth_hormone response to clonidine : relationship to clinical and neuroendocrine profile in depression .
6291085	0	clonidine	111,120	growth_hormone	84,98	clonidine	growth hormone	MESH:D003000	81668(Tax:10116)	Chemical	Gene	reflected|xcomp|START_ENTITY reflected|nmod|response response|amod|END_ENTITY	Up - and down - regulation of central postsynaptic alpha 2 receptors reflected in the growth_hormone response to clonidine in reserpine-pretreated rats .
6320028	0	clonidine	93,102	growth_hormone	59,73	clonidine	growth hormone	MESH:D003000	81668(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Effects Effects|nmod|treatment treatment|nmod|monosodium_glutamate monosodium_glutamate|nmod|release release|amod|END_ENTITY	Effects of neonatal treatment with monosodium_glutamate on growth_hormone release induced by clonidine and prostaglandin_E1 in conscious male rats .
6322574	0	clonidine	16,25	growth_hormone	61,75	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	agents|compound|START_ENTITY comparison|nmod|agents comparison|nmod|END_ENTITY	A comparison of clonidine and standard provocative agents of growth_hormone .
6482679	0	clonidine	127,136	growth_hormone	91,105	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	challenge|amod|START_ENTITY response|nmod|challenge response|compound|END_ENTITY	Possible change in noradrenergic receptor sensitivity following methylphenidate treatment : growth_hormone and MHPG response to clonidine challenge in children with attention_deficit_disorder and hyperactivity .
6501804	0	clonidine	20,29	growth_hormone	37,51	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|level level|amod|END_ENTITY	The effects of oral clonidine on the growth_hormone level in acromegalic patients .
6743929	0	clonidine	48,57	growth_hormone	20,34	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	comparison|acl|START_ENTITY comparison|nmod|responses responses|amod|END_ENTITY	A comparison of the growth_hormone responses to clonidine and apomorphine in the same patients with endogenous_depression .
6805018	0	clonidine	108,117	growth_hormone	51,65	clonidine	growth hormone	MESH:D003000	81668(Tax:10116)	Chemical	Gene	shocks|acl|START_ENTITY shocks|nmod|secretion secretion|amod|END_ENTITY	The effect of repeated electroconvulsive shocks on growth_hormone secretion and growth_hormone responses to clonidine in the intact rat .
6959166	0	clonidine	80,89	growth_hormone	53,67	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	alter|advcl|START_ENTITY alter|dobj|response response|amod|END_ENTITY	Failure of chronic antidepressant treatment to alter growth_hormone response to clonidine .
7160519	0	clonidine	39,48	growth_hormone	52,66	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	-LSB- Effect of long-term administration of clonidine on growth_hormone secretion in hypertensive diabetics -RSB- .
7283286	0	clonidine	6,15	growth_hormone	25,39	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	test|compound|START_ENTITY test|nmod|release release|amod|END_ENTITY	-LSB- Oral clonidine test for growth_hormone release -LRB- author 's transl -RRB- -RSB- .
7308974	0	clonidine	10,19	growth_hormone	23,37	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of clonidine on growth_hormone and glucagon secretion .
7333861	0	clonidine	5,14	growth_hormone	49,63	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	START_ENTITY|dep|test test|nmod|release release|amod|END_ENTITY	Oral clonidine : an effective provocative test of growth_hormone release .
7694915	0	clonidine	56,65	growth_hormone	29,43	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	blunted|advcl|START_ENTITY blunted|dobj|response response|compound|END_ENTITY	Persistence of blunted human growth_hormone response to clonidine in fluoxetine-treated patients with panic_disorder .
7887119	0	clonidine	23,32	growth_hormone	53,67	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|nmod|END_ENTITY	Effects of intravenous clonidine on the secretion of growth_hormone in the perioperative period .
8097332	0	clonidine	88,97	growth_hormone	44,58	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	comparison|nmod|START_ENTITY Guanfacine|dep|comparison Guanfacine|nmod|inducer inducer|nmod|secretion secretion|amod|END_ENTITY	Guanfacine as an alpha-2-agonist inducer of growth_hormone secretion -- a comparison with clonidine .
8296892	0	clonidine	62,71	growth_hormone	35,49	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	Effects|acl|START_ENTITY Effects|nmod|response response|amod|END_ENTITY	Effects of gender and diagnosis on growth_hormone response to clonidine for major_depression : a large-scale multicenter study .
8299303	0	clonidine	39,48	growth_hormone	58,72	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	test|amod|START_ENTITY test|nmod|reserve reserve|amod|END_ENTITY	Hypoglycemia due to sedation following clonidine test for growth_hormone reserve .
8307113	0	clonidine	69,78	growth_hormone	41,55	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	Effects|acl|START_ENTITY Effects|nmod|status status|nmod|responses responses|amod|END_ENTITY	Effects of thyroid hormone status on the growth_hormone responses to clonidine .
8380310	0	clonidine	48,57	growth_hormone	23,37	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	stimulation|amod|START_ENTITY Effects|nmod|stimulation Effects|nmod|END_ENTITY	Effects of estrogen on growth_hormone following clonidine stimulation .
8419612	0	clonidine	19,28	growth_hormone	89,103	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	administration|compound|START_ENTITY administration|nmod|velocity velocity|nmod|children children|nmod|deficiency deficiency|amod|END_ENTITY	Effects of nightly clonidine administration on growth velocity in short children without growth_hormone deficiency : a double-blind , placebo-controlled study .
8531260	0	clonidine	105,114	growth_hormone	12,26	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	GH|advcl|START_ENTITY GH|nsubj|END_ENTITY	Circulating growth_hormone -LRB- GH -RRB- , insulin-like growth factor-I -LRB- IGF-I -RRB- and free thyroxine , GH response to clonidine provocation and CT scanning of the hypothalamic-pituitary area in children with sickle_cell_disease .
8606442	0	clonidine	59,68	growth_hormone	10,24	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	response|acl|START_ENTITY secretion|dobj|response secretion|nsubj|END_ENTITY	Nocturnal growth_hormone -LRB- GH -RRB- secretion and GH response to clonidine provocation in children before and after long-term prednisone therapy .
8816035	0	clonidine	51,60	growth_hormone	19,33	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	insulin-like_growth_factor-I|amod|START_ENTITY response|dep|insulin-like_growth_factor-I response|amod|END_ENTITY	Growth parameters , growth_hormone -LRB- GH -RRB- response to clonidine and circulating insulin-like_growth_factor-I -LRB- IGF-I -RRB- , free thyroxine -LRB- FT4 -RRB- and cortisol concentrations in relation to glycaemic control in children with insulin-dependent_diabetes_mellitus .
8918979	0	clonidine	93,102	growth_hormone	106,120	clonidine	growth hormone	MESH:D003000	81668(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY recovery|nmod|effect influences|dobj|recovery influences|nmod|secretion secretion|amod|END_ENTITY	The pattern of testosterone replacement influences the recovery of the stimulatory effect of clonidine on growth_hormone -LRB- GH -RRB- secretion in orchidectomized rats .
8951963	0	clonidine	44,53	growth_hormone	66,80	clonidine	growth hormone	MESH:D003000	81668(Tax:10116)	Chemical	Gene	effect|nmod:poss|START_ENTITY effect|nmod|secretion secretion|amod|END_ENTITY	Long-term antidepressant treatment restores clonidine 's effect on growth_hormone secretion in a genetic animal model of depression .
9133220	0	clonidine	20,29	growth_hormone	112,126	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	tests|amod|START_ENTITY Sensitivity|nmod|tests Sensitivity|nmod|END_ENTITY	-LSB- Sensitivity of the clonidine and guanfacine tests -LRB- alpha-2-adrenergic agonists -RRB- as pharmacologic stimulants of growth_hormone .
9203090	0	clonidine	103,112	growth_hormone	35,49	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	Effect|amod|START_ENTITY Effect|nmod|sleep_deprivation sleep_deprivation|nmod|response response|amod|END_ENTITY	Effect of sleep_deprivation on the growth_hormone response to the alpha-3 adrenergic receptor agonist , clonidine , in normal subjects .
9210208	0	clonidine	70,79	growth_hormone	24,38	clonidine	growth hormone	MESH:D003000	2688	Chemical	Gene	stability|nmod|START_ENTITY stability|nmod|END_ENTITY	The stability of plasma growth_hormone and MHPG responses to repeated clonidine challenge in normal males .
9267532	0	clonidine	136,145	growth_hormone	60,74	clonidine	growth hormone	MESH:D003000	81668(Tax:10116)	Chemical	Gene	feedback|amod|START_ENTITY induced|nmod|feedback induced|nsubj|Effect Effect|nmod|exposure exposure|nmod|release release|nmod|END_ENTITY	Effect of fetal ethanol exposure on the in vitro release of growth_hormone , somatostatin and growth_hormone-releasing factor induced by clonidine and growth_hormone feedback in male and female rats .
2575711	0	clonidine	15,24	insulin	28,35	clonidine	insulin	MESH:D003000	3630	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	Dual action of clonidine on insulin release : suppression , but stimulation when alpha 2-adrenoceptors are blocked .
3542627	0	clonidine	10,19	insulin	23,30	clonidine	insulin	MESH:D003000	3630	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Effect of clonidine on insulin secretion : a case report .
1000443	0	clonidine	39,48	renin	59,64	clonidine	renin	MESH:D003000	5972	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|compound|END_ENTITY	Effects of long-term administration of clonidine on plasma renin activity .
1120965	0	clonidine	70,79	renin	51,56	clonidine	renin	MESH:D003000	403838(Tax:9615)	Chemical	Gene	secretion|nmod|START_ENTITY Studies|acl|secretion Studies|nmod|END_ENTITY	Studies concerning the mechanism of suppression of renin secretion by clonidine .
1155220	0	clonidine	81,90	renin	7,12	clonidine	renin	MESH:D003000	5972	Chemical	Gene	treatment|nmod|START_ENTITY END_ENTITY|nmod|treatment	Plasma renin activity , blood pressure and sodium excretion during treatment with clonidine .
21991736	0	clonidine	11,20	renin	48,53	clonidine	renin	MESH:D003000	5972	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of clonidine as premedication on plasma renin activity , serum and urine electrolytes and body fluids in general anesthesia .
238481	0	clonidine	14,23	renin	98,103	clonidine	renin	MESH:D003000	5972	Chemical	Gene	effect|nmod|START_ENTITY plasma|nsubj|effect plasma|dobj|activity activity|compound|END_ENTITY	The effect of clonidine and penbutolol , respectively on catecholamines in blood and urine , plasma renin activity and urinary aldosterone in hypertensive patients .
6120802	0	clonidine	33,42	renin	14,19	clonidine	renin	MESH:D003000	403838(Tax:9615)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of renin secretion by clonidine after alpha-adrenoceptor blockade in anesthetized dogs .
620441	0	clonidine	47,56	renin	28,33	clonidine	renin	MESH:D003000	403838(Tax:9615)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Mechanism Mechanism|nmod|suppression suppression|nmod|END_ENTITY	Mechanism of suppression of renin secretion by clonidine in the dog .
6392861	0	clonidine	92,101	renin	37,42	clonidine	renin	MESH:D003000	5972	Chemical	Gene	-RSB-|amod|START_ENTITY administration|nmod|-RSB- children|nmod|administration activity|nmod|children activity|compound|END_ENTITY	-LSB- Growth_hormone secretion and plasma renin activity in children following administration of clonidine -RSB- .
648588	0	clonidine	44,53	renin	27,32	clonidine	renin	MESH:D003000	24715(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|Mechanism Mechanism|nmod|inhibition inhibition|nmod|END_ENTITY	Mechanism of inhibition of renin release by clonidine in rats .
6989768	0	clonidine	14,23	renin	27,32	clonidine	renin	MESH:D003000	5972	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of clonidine on renin and aldosterone of hypertensive patients .
700917	0	clonidine	10,19	renin	41,46	clonidine	renin	MESH:D003000	5972	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|level level|compound|END_ENTITY	Effect of clonidine -LRB- Haemiton -RRB- on plasma renin level and angiotensin sensitivity in man .
7015796	0	clonidine	10,19	renin	47,52	clonidine	renin	MESH:D003000	5972	Chemical	Gene	treatment|compound|START_ENTITY treatment|dep|activity activity|dep|END_ENTITY	Prolonged clonidine treatment : catecholamines , renin activity and aldosterone following exercise in hypertensives .
707522	0	clonidine	79,88	renin	8,13	clonidine	renin	MESH:D003000	5972	Chemical	Gene	mechanism|nmod|START_ENTITY Role|nmod|mechanism Role|nmod|suppression suppression|compound|END_ENTITY	Role of renin and aldosterone suppression in the antihypertensive mechanism of clonidine .
21803431	0	clopidogrel	23,34	BDNF	65,69	clopidogrel	BDNF	MESH:C055162	627	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|release release|nmod|END_ENTITY	Differential effect of clopidogrel and aspirin on the release of BDNF from platelets .
16442924	0	clopidogrel	11,22	CD40_ligand	34,45	clopidogrel	CD40 ligand	MESH:C055162	959	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of clopidogrel on soluble CD40_ligand and on high-sensitivity C-reactive protein in patients with stable coronary_artery_disease .
22313038	0	clopidogrel	66,77	CYP2B6	114,120	clopidogrel	CYP2B6	MESH:C055162	1555	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Different effects of proton pump inhibitors and famotidine on the clopidogrel metabolic activation by recombinant CYP2B6 , CYP2C19 and CYP3A4 .
17697139	0	clopidogrel	54,65	CYP2C19	13,20	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	responsiveness|amod|START_ENTITY polymorphisms|nmod|responsiveness polymorphisms|nsubj|Influence Influence|nmod|gene gene|compound|END_ENTITY	Influence of CYP2C19 and CYP3A4 gene polymorphisms on clopidogrel responsiveness in healthy subjects .
17900275	0	clopidogrel	102,113	CYP2C19	24,31	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	affect|advcl|START_ENTITY affect|nsubj|polymorphisms polymorphisms|nmod|END_ENTITY	Common polymorphisms of CYP2C19 and CYP2C9 affect the pharmacokinetic and pharmacodynamic response to clopidogrel but not prasugrel .
18323861	0	clopidogrel	121,132	CYP2C19	14,21	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	resistance|amod|START_ENTITY mechanism|nmod|resistance effect|dep|mechanism effect|nmod|polymorphism polymorphism|compound|END_ENTITY	The effect of CYP2C19 polymorphism on the pharmacokinetics and pharmacodynamics of clopidogrel : a possible mechanism for clopidogrel resistance .
18323861	0	clopidogrel	83,94	CYP2C19	14,21	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY polymorphism|nmod|pharmacokinetics polymorphism|compound|END_ENTITY	The effect of CYP2C19 polymorphism on the pharmacokinetics and pharmacodynamics of clopidogrel : a possible mechanism for clopidogrel resistance .
18346178	0	clopidogrel	50,61	CYP2C19	76,83	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	platelet_aggregation|nmod|START_ENTITY Inhibition|nmod|platelet_aggregation related|nsubjpass|Inhibition related|nmod|polymorphisms polymorphisms|nummod|END_ENTITY	Inhibition of ADP-induced platelet_aggregation by clopidogrel is related to CYP2C19 genetic polymorphisms .
18532997	0	clopidogrel	108,119	CYP2C19	28,35	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	metabolite|nmod|START_ENTITY affect|nmod|metabolite affect|nsubj|variants variants|nmod|END_ENTITY	The common gene variants of CYP2C19 affect pharmacokinetics and pharmacodynamics in an active metabolite of clopidogrel in healthy subjects .
18781853	0	clopidogrel	62,73	CYP2C19	0,7	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	predict|xcomp|START_ENTITY predict|nsubj|END_ENTITY	CYP2C19 and nongenetic factors predict poor responsiveness to clopidogrel loading dose after coronary stent implantation .
19429918	0	clopidogrel	91,102	CYP2C19	21,28	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	affects|advcl|START_ENTITY affects|nsubj|variation variation|nmod|END_ENTITY	Genetic variation of CYP2C19 affects both pharmacokinetic and pharmacodynamic responses to clopidogrel but not prasugrel in aspirin-treated patients with coronary_artery_disease .
19496924	0	clopidogrel	69,80	CYP2C19	4,11	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	associated|xcomp|START_ENTITY associated|nsubjpass|allele allele|compound|END_ENTITY	The CYP2C19 * 17 allele is associated with better platelet response to clopidogrel in patients admitted for non-ST acute_coronary_syndrome .
19531897	0	clopidogrel	62,73	CYP2C19	10,17	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	effect|nmod|START_ENTITY polymorphisms|nmod|effect polymorphisms|nsubj|Impact Impact|nmod|END_ENTITY	Impact of CYP2C19 polymorphisms on the antiplatelet effect of clopidogrel in an actual clinical setting in Japan .
19624462	0	clopidogrel	70,81	CYP2C19	0,7	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	response|acl|START_ENTITY determinant|nmod|response determinant|dep|END_ENTITY	CYP2C19 * 2 polymorphism is not the sole determinant of the response to clopidogrel : implications for its monitoring .
19995331	0	clopidogrel	20,31	CYP2C19	97,104	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	inhibitors|amod|START_ENTITY Interaction|nmod|inhibitors Interaction|dep|hypothesis hypothesis|acl|explain explain|dobj|inhibition inhibition|compound|END_ENTITY	Interaction between clopidogrel and proton pump inhibitors : hypothesis to explain multifactorial CYP2C19 inhibition .
20166430	0	clopidogrel	57,68	CYP2C19	8,15	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	therapy|amod|START_ENTITY polymorphism|nmod|therapy polymorphism|nsubj|END_ENTITY	Genetic CYP2C19 polymorphism dependent non-responders to clopidogrel therapy -- does structural design , dosing and induction strategies have a role to play ?
20492469	0	clopidogrel	105,116	CYP2C19	42,49	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	therapy|amod|START_ENTITY effect|nmod|therapy impact|nmod|effect impact|nmod|variants variants|compound|END_ENTITY	Isolated and interactive impact of common CYP2C19 genetic variants on the antiplatelet effect of chronic clopidogrel therapy .
20716239	0	clopidogrel	80,91	CYP2C19	107,114	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	function|nmod|START_ENTITY inhibitors|nmod|function pump|dobj|inhibitors pump|nmod|genotypes genotypes|nummod|END_ENTITY	Influences of different proton pump inhibitors on the anti-platelet function of clopidogrel in relation to CYP2C19 genotypes .
20801498	0	clopidogrel	108,119	CYP2C19	10,17	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	ticagrelor|nmod|START_ENTITY treatment|nmod|ticagrelor outcomes|nmod|treatment Effect|nmod|outcomes Effect|nmod|polymorphisms polymorphisms|compound|END_ENTITY	Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute_coronary_syndromes : a genetic substudy of the PLATO trial .
20826260	0	clopidogrel	79,90	CYP2C19	25,32	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	activation|nmod|START_ENTITY polymorphism|nmod|activation effect|dep|polymorphism effect|nmod|END_ENTITY	Protective effect of the CYP2C19 * 17 polymorphism with increased activation of clopidogrel on cardiovascular events .
20978260	0	clopidogrel	100,111	CYP2C19	17,24	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	predominantly|amod|START_ENTITY treated|nmod|predominantly patients|acl|treated outcomes|nmod|patients genotype|nmod|outcomes genotype|nsubj|END_ENTITY	Reduced-function CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PCI : a meta-analysis .
20979470	0	clopidogrel	43,54	CYP2C19	11,18	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	treatment|amod|START_ENTITY outcomes|nmod|treatment genotype|nmod|outcomes genotype|nsubj|Effects Effects|nmod|END_ENTITY	Effects of CYP2C19 genotype on outcomes of clopidogrel treatment .
21079055	0	clopidogrel	120,131	CYP2C19	39,46	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	ticagrelor|nmod|START_ENTITY treated|nmod|ticagrelor patients|acl|treated genotype|nmod|patients genotype|compound|END_ENTITY	First analysis of the relation between CYP2C19 genotype and pharmacodynamics in patients treated with ticagrelor versus clopidogrel : the ONSET/OFFSET and RESPOND genotype studies .
21163112	0	clopidogrel	58,69	CYP2C19	10,17	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	Impact|acl|START_ENTITY Impact|nmod|polymorphism polymorphism|compound|END_ENTITY	Impact of CYP2C19 polymorphism and smoking on response to clopidogrel in patients with stable coronary_artery_disease .
21178986	0	clopidogrel	82,93	CYP2C19	24,31	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	effects|nmod|START_ENTITY polymorphisms|nmod|effects polymorphisms|nsubj|impacts impacts|nmod|gene gene|compound|END_ENTITY	Differential impacts of CYP2C19 gene polymorphisms on the antiplatelet effects of clopidogrel and ticlopidine .
21285422	0	clopidogrel	72,83	CYP2C19	29,36	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	treated|nmod|START_ENTITY patients|acl|treated allele|nmod|patients allele|nsubj|Carriage Carriage|nmod|END_ENTITY	Carriage of reduced-function CYP2C19 allele among patients treated with clopidogrel .
21288101	0	clopidogrel	33,44	CYP2C19	0,7	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	treatment|amod|START_ENTITY genotype|nmod|treatment genotype|compound|END_ENTITY	CYP2C19 genotype and outcomes of clopidogrel treatment .
21288102	0	clopidogrel	33,44	CYP2C19	0,7	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	treatment|amod|START_ENTITY genotype|nmod|treatment genotype|compound|END_ENTITY	CYP2C19 genotype and outcomes of clopidogrel treatment .
21302482	0	clopidogrel	72,83	CYP2C19	41,48	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	resistance|amod|START_ENTITY polymorphism|nmod|resistance polymorphism|nsubj|Relationships Relationships|nmod|gene gene|amod|END_ENTITY	-LSB- Relationships of blood_stasis_syndrome , CYP2C19 gene polymorphism with clopidogrel resistance and post-PCI prognosis -RSB- .
21358751	0	clopidogrel	89,100	CYP2C19	18,25	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	responsiveness|amod|START_ENTITY metabolism|nmod|responsiveness implications|nmod|metabolism Identification|dep|implications Identification|nmod|END_ENTITY	Identification of CYP2C19 * 4B : pharmacogenetic implications for drug metabolism including clopidogrel responsiveness .
21511219	0	clopidogrel	115,126	CYP2C19	146,153	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	START_ENTITY|dep|importance importance|nmod|END_ENTITY	Prasugrel overcomes high on-clopidogrel platelet reactivity post-stenting more effectively than high-dose -LRB- 150-mg -RRB- clopidogrel : the importance of CYP2C19 * 2 genotyping .
21628721	0	clopidogrel	93,104	CYP2C19	61,68	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	patients|amod|START_ENTITY modest|nmod|patients explained|dep|modest explained|nmod|END_ENTITY	Variability in on-treatment platelet reactivity explained by CYP2C19 * 2 genotype is modest in clopidogrel pretreated patients undergoing coronary stenting .
21693476	0	clopidogrel	183,194	CYP2C19	52,59	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|Meta-analyses Meta-analyses|nmod|association association|nmod|loss loss|compound|END_ENTITY	Meta-analyses of the association between cytochrome CYP2C19 loss - and gain-of-function polymorphisms and cardiovascular outcomes in patients with coronary_artery_disease treated with clopidogrel .
21719206	0	clopidogrel	32,43	CYP2C19	5,12	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	lead|xcomp|START_ENTITY lead|nsubj|inhibition inhibition|compound|END_ENTITY	Does CYP2C19 inhibition lead to clopidogrel thrombogenicity ?
21795468	0	clopidogrel	164,175	CYP2C19	116,123	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	coadministration|nmod|START_ENTITY implications|nmod|coadministration inhibitor|dep|implications inhibitor|nmod|END_ENTITY	The proton pump inhibitor , omeprazole , but not lansoprazole or pantoprazole , is a metabolism-dependent inhibitor of CYP2C19 : implications for coadministration with clopidogrel .
21803320	0	clopidogrel	19,30	CYP2C19	61,68	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	dose|amod|START_ENTITY dose|nmod|END_ENTITY	Usefulness of high clopidogrel maintenance dose according to CYP2C19 genotypes in clopidogrel low responders undergoing coronary stenting for non ST elevation acute_coronary_syndrome .
21803320	0	clopidogrel	82,93	CYP2C19	61,68	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	responders|amod|START_ENTITY genotypes|nmod|responders genotypes|nsubj|Usefulness Usefulness|nmod|dose dose|nmod|END_ENTITY	Usefulness of high clopidogrel maintenance dose according to CYP2C19 genotypes in clopidogrel low responders undergoing coronary stenting for non ST elevation acute_coronary_syndrome .
21816733	0	clopidogrel	88,99	CYP2C19	10,17	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	treatment|nmod|START_ENTITY efficacy|nmod|treatment genotypes|nmod|efficacy genotypes|nummod|END_ENTITY	Impact of CYP2C19 variant genotypes on clinical efficacy of antiplatelet treatment with clopidogrel : systematic review and meta-analysis .
21831410	0	clopidogrel	68,79	CYP2C19	0,7	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	affecting|advcl|START_ENTITY *|dep|affecting *|nsubj|END_ENTITY	CYP2C19 * 2 and other genetic variants affecting platelet response to clopidogrel in patients undergoing percutaneous coronary intervention .
21972404	0	clopidogrel	48,59	CYP2C19	0,7	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	pharmacokinetics|amod|START_ENTITY influence|dobj|pharmacokinetics influence|nsubj|END_ENTITY	CYP2C19 but not PON1 genetic variants influence clopidogrel pharmacokinetics , pharmacodynamics , and clinical efficacy in post-myocardial_infarction patients .
22004687	0	clopidogrel	65,76	CYP2C19	50,57	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	metabolite|amod|START_ENTITY Effects|nmod|metabolite Effects|nmod|END_ENTITY	Effects of omeprazole and genetic polymorphism of CYP2C19 on the clopidogrel active metabolite .
22045970	0	clopidogrel	168,179	CYP2C19	10,17	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|Effect Effect|nmod|END_ENTITY	Effect of CYP2C19 * 2 and * 3 loss-of-function alleles on platelet reactivity and adverse clinical events in East Asian acute_myocardial_infarction survivors treated with clopidogrel and aspirin .
22088980	0	clopidogrel	7,18	CYP2C19	28,35	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	Dosing|dobj|START_ENTITY based|csubj|Dosing based|nmod|genotype genotype|nummod|END_ENTITY	Dosing clopidogrel based on CYP2C19 genotype and the effect on platelet reactivity in patients with stable cardiovascular_disease .
22166969	0	clopidogrel	14,25	CYP2C19	52,59	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	low|amod|START_ENTITY Prediction|nmod|low responders|nsubj|Prediction responders|nmod|test test|compound|END_ENTITY	Prediction of clopidogrel low responders by a rapid CYP2C19 activity test .
22374717	0	clopidogrel	66,77	CYP2C19	29,36	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	bioactivation|amod|START_ENTITY mechanism|nmod|bioactivation Clarifying|nmod|mechanism Clarifying|dobj|importance importance|nmod|END_ENTITY	Clarifying the importance of CYP2C19 and PON1 in the mechanism of clopidogrel bioactivation and in vivo antiplatelet response .
22462746	0	clopidogrel	42,53	CYP2C19	0,7	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	bioactivation|amod|START_ENTITY regulating|dobj|bioactivation polymorphisms|xcomp|regulating polymorphisms|nsubj|END_ENTITY	CYP2C19 and PON1 polymorphisms regulating clopidogrel bioactivation in Chinese , Malay and Indian subjects .
22542748	0	clopidogrel	62,73	CYP2C19	110,117	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	doses|amod|START_ENTITY prevent|nmod|doses rabeprazole|acl|prevent Ability|nmod|rabeprazole depends|nsubj|Ability depends|nmod|genotype genotype|compound|END_ENTITY	Ability of rabeprazole to prevent gastric_mucosal_damage from clopidogrel and low doses of aspirin depends on CYP2C19 genotype .
22589111	0	clopidogrel	17,28	CYP2C19	57,64	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	resistance|amod|START_ENTITY resistance|nmod|genotyping genotyping|nmod|END_ENTITY	Rapid testing of clopidogrel resistance by genotyping of CYP2C19 and CYP2C9 polymorphisms using denaturing on-chip capillary electrophoresis .
22685981	0	clopidogrel	63,74	CYP2C19	0,7	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	resistance|amod|START_ENTITY genotype-guided|nmod|resistance genotype-guided|nsubj|END_ENTITY	CYP2C19 genotype-guided antiplatelet therapy in a patient with clopidogrel resistance .
22839512	0	clopidogrel	74,85	CYP2C19	1,8	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	-RSB-|amod|START_ENTITY use|dobj|-RSB- patients|acl:relcl|use polymorphism|nmod|patients polymorphism|nsubj|gene gene|compound|END_ENTITY	-LSB- CYP2C19 gene polymorphism in patients with myocardial_infarction who use clopidogrel -RSB- .
22875498	0	clopidogrel	49,60	CYP2C19	15,22	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	metabolism|amod|START_ENTITY involved|nmod|metabolism involved|nsubj|Prevalence Prevalence|nmod|polymorphisms polymorphisms|nummod|END_ENTITY	-LSB- Prevalence of CYP2C19 polymorphisms involved in clopidogrel metabolism in Fujian Han population -RSB- .
22875511	0	clopidogrel	74,85	CYP2C19	114,121	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	START_ENTITY|nmod|individuals individuals|nmod|END_ENTITY	-LSB- Impact of proton pump inhibitor omeprazole on the antiplatelet effect of clopidogrel in individuals with various CYP2C19 * 2 genotypes -RSB- .
22955794	0	clopidogrel	60,71	CYP2C19	25,32	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	response|acl|START_ENTITY influences|dobj|response influences|nsubj|polymorphisms polymorphisms|nmod|END_ENTITY	Genetic polymorphisms of CYP2C19 influences the response to clopidogrel in ischemic_heart_disease patients in the South Indian Tamilian population .
22971905	0	clopidogrel	140,151	CYP2C19	15,22	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	pretreatment|amod|START_ENTITY receiving|dobj|pretreatment genotype|advcl|receiving genotype|nsubj|Association Association|nmod|END_ENTITY	Association of CYP2C19 genotype with periprocedural myocardial_infarction after uneventful stent implantation in Chinese patients receiving clopidogrel pretreatment .
23016454	0	clopidogrel	54,65	CYP2C19	0,7	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	polymorphism|nmod|START_ENTITY _|dobj|polymorphism _|nsubj|> >|nummod|681G 681G|compound|END_ENTITY	CYP2C19 681G _ > _ A polymorphism and pharmacokinetics of clopidogrel in Chinese healthy volunteers .
23340030	0	clopidogrel	69,80	CYP2C19	10,17	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	dose|amod|START_ENTITY *|nmod|dose *|nsubj|Effect Effect|nmod|END_ENTITY	Effect of CYP2C19 * 2 and * 17 genetic variants on platelet response to clopidogrel and prasugrel maintenance dose and relation to bleeding complications .
23364775	0	clopidogrel	38,49	CYP2C19	155,162	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	therapy|amod|START_ENTITY patients|nmod|therapy Cardiovascular_risk|nmod|patients Cardiovascular_risk|advcl|modified modified|nmod|variants variants|nmod|END_ENTITY	Cardiovascular_risk among patients on clopidogrel anti-platelet therapy after placement of drug-eluting stents is modified by genetic variants in both the CYP2C19 and ABCB1 genes .
23402725	0	clopidogrel	131,142	CYP2C19	14,21	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	patients|nmod|START_ENTITY genotype|nmod|patients genotype|nsubj|impact impact|nmod|END_ENTITY	The impact of CYP2C19 genotype on cardiovascular events and platelet reactivity in patients with coronary_artery_disease receiving clopidogrel .
23429358	0	clopidogrel	63,74	CYP2C19	16,23	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	variability|amod|START_ENTITY polymorphism|nmod|variability Relationship|dep|polymorphism Relationship|nmod|END_ENTITY	Relationship of CYP2C19 * 2 and CYP2C19 * 3 gene polymorphism with clopidogrel response variability and recurrent cardiovascular events in Chinese patients undergoing percutaneous coronary intervention .
23431496	2	clopidogrel	208,219	CYP2C19	132,139	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	effect|nmod|START_ENTITY associated|nmod|effect associated|nsubjpass|allele allele|nummod|2 2|compound|END_ENTITY	The CYP2C19 2 allele may be associated with a reduced antiplatelet effect for clopidogrel .
23470885	0	clopidogrel	90,101	CYP2C19	21,28	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	treatment|amod|START_ENTITY polymorphism|nmod|treatment polymorphism|nummod|END_ENTITY	Relationship between CYP2C19 loss-of-function polymorphism and platelet reactivities with clopidogrel treatment in Japanese patients undergoing coronary stent implantation .
23474843	0	clopidogrel	104,115	CYP2C19	0,7	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	action|nmod|START_ENTITY effect|nmod|action have|dobj|effect have|nsubj|polymorphism polymorphism|nummod|END_ENTITY	CYP2C19 genetic polymorphism , rabeprazole and esomeprazole have no effect on the antiplatelet action of clopidogrel .
23506580	0	clopidogrel	60,71	CYP2C19	39,46	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	responsiveness|amod|START_ENTITY Effects|nmod|responsiveness Effects|nmod|END_ENTITY	Effects of coexisting polymorphisms of CYP2C19 and P2Y12 on clopidogrel responsiveness and clinical outcome in patients with acute_coronary_syndromes undergoing stent-based coronary intervention .
23556336	0	clopidogrel	49,60	CYP2C19	0,7	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	polymorphism|nmod|START_ENTITY polymorphism|nummod|END_ENTITY	CYP2C19 polymorphism and antiplatelet effects of clopidogrel in Chinese stroke patients .
23607088	0	clopidogrel	87,98	CYP2C19	48,55	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	reactivity|amod|START_ENTITY predicting|dobj|reactivity test|advcl|predicting test|nsubj|Feasibility Feasibility|nmod|genotyping genotyping|compound|END_ENTITY	Feasibility of a microarray-based point-of-care CYP2C19 genotyping test for predicting clopidogrel on-treatment platelet reactivity .
23640828	0	clopidogrel	50,61	CYP2C19	0,7	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	polymorphisms|nmod|START_ENTITY polymorphisms|nummod|END_ENTITY	CYP2C19 polymorphisms and antiplatelet effects of clopidogrel in acute ischemic_stroke in China .
23643422	0	clopidogrel	33,44	CYP2C19	122,129	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	blockers|amod|START_ENTITY synergy|nmod|blockers involves|nsubj|synergy involves|dobj|rs4244285 rs4244285|nummod|END_ENTITY	Newly identified synergy between clopidogrel and calcium-channel blockers for blood pressure regulation possibly involves CYP2C19 rs4244285 .
23809542	0	clopidogrel	60,71	CYP2C19	4,11	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	response|amod|START_ENTITY associated|nmod|response associated|nsubjpass|variant variant|compound|END_ENTITY	The CYP2C19 * 17 variant is not independently associated with clopidogrel response .
23850044	0	clopidogrel	108,119	CYP2C19	14,21	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	-RSB-|amod|START_ENTITY treated|nmod|-RSB- Relevance|acl|treated Relevance|nmod|2 2|compound|END_ENTITY	-LSB- Relevance of CYP2C19 2 regarding platelet reactivity in patients with acute_coronary_syndrome treated with clopidogrel -RSB- .
23922007	0	clopidogrel	65,76	CYP2C19	14,21	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	therapy|amod|START_ENTITY outcome|nmod|therapy undergoing|nsubj|outcome percutaneous|advcl|undergoing percutaneous|nsubj|Impact Impact|nmod|END_ENTITY	Impact of the CYP2C19 * 17 polymorphism on the clinical outcome of clopidogrel therapy in Asian patients undergoing percutaneous coronary intervention .
24012947	0	clopidogrel	133,144	CYP2C19	76,83	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	testing|amod|START_ENTITY implications|nmod|testing system|dep|implications system|nmod|END_ENTITY	An allele-specific PCR system for rapid detection and discrimination of the CYP2C19 4A , 4B , and 17 alleles : implications for clopidogrel response testing .
24012947	6	clopidogrel	1708,1719	CYP2C19	1534,1541	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	response|amod|START_ENTITY CYP2C19|nmod|response testing|dobj|CYP2C19 have|advcl|testing variants|acl:relcl|have phase|nmod|variants determining|dobj|phase refine|advcl|determining refine|dobj|genotyping genotyping|compound|END_ENTITY	In conclusion , this rapid and robust allele-specific PCR assay can refine CYP2C19 genotyping and metabolizer phenotype classification by determining the phase of the defining 17 and 4 variants , which may have utility when testing CYP2C19 for clopidogrel response .
24019397	0	clopidogrel	64,75	CYP2C19	0,7	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	therapy|amod|START_ENTITY outcome|nmod|therapy associated|nmod|outcome associated|nsubjpass|metabolizer metabolizer|nummod|END_ENTITY	CYP2C19 poor metabolizer is associated with clinical outcome of clopidogrel therapy in acute myocardial_infarction but not stable_angina .
24019752	0	clopidogrel	74,85	CYP2C19	0,7	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	polymorphisms|xcomp|START_ENTITY polymorphisms|nsubj|END_ENTITY	CYP2C19 polymorphisms in the Thai population and the clinical response to clopidogrel in patients with atherothrombotic-risk factors .
24080149	0	clopidogrel	35,46	CYP2C19	59,66	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	response|amod|START_ENTITY response|nmod|carriers carriers|nummod|END_ENTITY	Paraoxonase-1 activity affects the clopidogrel response in CYP2C19 loss-of-function carriers .
24214141	0	clopidogrel	91,102	CYP2C19	14,21	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	administration|amod|START_ENTITY genotype|nmod|administration genotype|nsubj|effect effect|nmod|END_ENTITY	The effect of CYP2C19 genotype on the time course of platelet_aggregation inhibition after clopidogrel administration .
24246616	1	clopidogrel	222,233	CYP2C19	300,307	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	efficacy|amod|START_ENTITY interact|nmod|efficacy interact|advcl|inhibiting inhibiting|dobj|formation formation|nmod|metabolite metabolite|nmod|inhibition inhibition|compound|END_ENTITY	BACKGROUND : Several studies have suggested that proton-pump inhibitors -LRB- PPIs -RRB- , mostly omeprazole , interact with clopidogrel efficacy by inhibiting the formation of its active metabolite via CYP2C19 inhibition .
24279856	0	clopidogrel	67,78	CYP2C19	28,35	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	selection|nmod|START_ENTITY guide|dobj|selection genotype|xcomp|guide genotype|nsubj|Cost-effectiveness Cost-effectiveness|acl|using using|dobj|END_ENTITY	Cost-effectiveness of using CYP2C19 genotype to guide selection of clopidogrel or ticagrelor in Australia .
24440142	0	clopidogrel	84,95	CYP2C19	10,17	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	outcomes|amod|START_ENTITY pump|nmod|outcomes pump|nsubj|Impact Impact|nmod|polymorphism polymorphism|compound|END_ENTITY	Impact of CYP2C19 polymorphism and proton pump inhibitors on platelet reactivity to clopidogrel and clinical outcomes following stent implantation .
24535487	0	clopidogrel	77,88	CYP2C19	35,42	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	variability|amod|START_ENTITY polymorphisms|nmod|variability polymorphisms|nummod|END_ENTITY	The effects of CES1A2 A -LRB- -816 -RRB- C and CYP2C19 loss-of-function polymorphisms on clopidogrel response variability among Chinese patients with coronary_heart_disease .
24608794	0	clopidogrel	85,96	CYP2C19	0,7	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	variety|amod|START_ENTITY impact|dobj|variety impact|nsubj|polymorphisms polymorphisms|nummod|END_ENTITY	CYP2C19 polymorphisms and coronary_heart_disease risk factors synergistically impact clopidogrel response variety after percutaneous coronary intervention .
24710841	0	clopidogrel	17,28	CYP2C19	113,120	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	dose|amod|START_ENTITY Effectiveness|nmod|dose escalation|nsubj|Effectiveness escalation|xcomp|normalize normalize|nmod|metabolizers metabolizers|nummod|END_ENTITY	Effectiveness of clopidogrel dose escalation to normalize active metabolite exposure and antiplatelet effects in CYP2C19 poor metabolizers .
24877854	0	clopidogrel	78,89	CYP2C19	18,25	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	therapy|amod|START_ENTITY have|nmod|therapy have|nsubj|Patients Patients|acl|carrying carrying|dobj|loss loss|nummod|END_ENTITY	Patients carrying CYP2C19 loss of function alleles have a reduced response to clopidogrel therapy and a greater risk of in-stent restenosis after endovascular treatment of lower_extremity_peripheral_arterial_disease .
24945780	0	clopidogrel	42,53	CYP2C19	21,28	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	activation|amod|START_ENTITY allele|nmod|activation *|dobj|allele *|nsubj|influence influence|nmod|END_ENTITY	The influence of the CYP2C19 * 10 allele on clopidogrel activation and CYP2C19 * 2 genotyping .
25001882	0	clopidogrel	63,74	CYP2C19	34,41	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	2-oxidation|amod|START_ENTITY variants|nmod|2-oxidation variants|nummod|END_ENTITY	Functional characterization of 21 CYP2C19 allelic variants for clopidogrel 2-oxidation .
25043069	0	clopidogrel	47,58	CYP2C19	108,115	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	maintenance_dose|nmod|START_ENTITY loading|nmod|maintenance_dose loading|nmod|END_ENTITY	Comparison of loading with maintenance_dose of clopidogrel on platelet reactivity in Chinese with different CYP2C19 genotypes prior to percutaneous coronary intervention .
25083217	0	clopidogrel	24,35	CYP2C19	105,112	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	activation|nmod|START_ENTITY provide|nsubj|activation provide|dobj|evidence evidence|nmod|contributions contributions|nmod|END_ENTITY	Metabolic activation of clopidogrel : in vitro data provide conflicting evidence for the contributions of CYP2C19 and PON1 .
25428337	0	clopidogrel	99,110	CYP2C19	128,135	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	A randomized controlled trial of adjunctive Bunchang Naoxintong Capsule -LRB- -RRB- versus maintenance dose clopidogrel in patients with CYP2C19 * 2 polymorphism .
25463363	0	clopidogrel	49,60	CYP2C19	17,24	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Joint effects of CYP2C19 * 2 and smoking status on clopidogrel responsiveness in patients with acute_coronary_syndrome .
25489921	0	clopidogrel	121,132	CYP2C19	13,20	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|Influence Influence|nmod|polymorphisms polymorphisms|nummod|END_ENTITY	Influence of CYP2C19 polymorphisms on platelet reactivity and clinical outcomes in ischemic_stroke patients treated with clopidogrel .
25647335	0	clopidogrel	100,111	CYP2C19	58,65	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	variability|amod|START_ENTITY polymorphisms|nmod|variability polymorphisms|nummod|END_ENTITY	Comment on Xie et al. : The effects of CES1A2 A -LRB- -816 -RRB- C and CYP2C19 loss-of-function polymorphisms on clopidogrel response variability among Chinese patients with coronary_heart_disease .
25800075	0	clopidogrel	80,91	CYP2C19	14,21	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	Prevalence|nmod|START_ENTITY Prevalence|nmod|alleles alleles|nummod|END_ENTITY	Prevalence of CYP2C19 alleles , pharmacokinetic and pharmacodynamic variation of clopidogrel and prasugrel in Bangladeshi population .
25828136	0	clopidogrel	83,94	CYP2C19	0,7	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	dose|amod|START_ENTITY undergoing|dobj|dose patients|acl|undergoing influence|nmod|patients *|dobj|influence *|nsubj|END_ENTITY	CYP2C19 * 2 genotype influence in acute_coronary_syndrome patients undergoing serial clopidogrel dose tailoring based on platelet function testing : Analysis from randomized controlled trial NCT02096419 .
25877345	0	clopidogrel	90,101	CYP2C19	0,7	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	treated|nmod|START_ENTITY races|acl|treated patients|nmod|races polymorphism|nmod|patients polymorphism|nummod|END_ENTITY	CYP2C19 polymorphism and clinical outcomes among patients of different races treated with clopidogrel : A systematic review and meta-analysis .
26093533	0	clopidogrel	37,48	CYP2C19	69,76	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	response|nmod|START_ENTITY Determinants|nmod|response Determinants|dep|impact impact|nmod|genotype genotype|nummod|END_ENTITY	Determinants of subacute response to clopidogrel : relative impact of CYP2C19 genotype and PGE1/adenylate cyclase signalling .
26170954	0	clopidogrel	76,87	CYP2C19	33,40	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	resistance|amod|START_ENTITY associated|nmod|resistance variants|acl|associated distribution|dep|variants distribution|nmod|END_ENTITY	Allele frequency distribution of CYP2C19 * 2 allelic variants associated with clopidogrel resistance in cardiac patients .
26311225	0	clopidogrel	135,146	CYP2C19	11,18	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	treatment|amod|START_ENTITY patients|nmod|treatment polymorphism|nmod|patients polymorphism|nsubj|Effects Effects|nmod|END_ENTITY	Effects of CYP2C19 polymorphism on endothelial function , arterial stiffness and inflammation in coronary_artery_disease patients under clopidogrel treatment .
26426352	0	clopidogrel	55,66	CYP2C19	97,104	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|relation relation|nmod|END_ENTITY	The pharmacokinetic and pharmacodynamic interaction of clopidogrel and cilostazol in relation to CYP2C19 and CYP3A5 genotypes .
26445541	0	clopidogrel	11,22	CYP2C19	74,81	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	response|amod|START_ENTITY response|dep|algorithm algorithm|acl|comprising comprising|dobj|pharmacogenetics pharmacogenetics|compound|END_ENTITY	Optimizing clopidogrel dose response : a new clinical algorithm comprising CYP2C19 pharmacogenetics and drug interactions .
26550258	0	clopidogrel	81,92	CYP2C19	173,180	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	efficacy|nmod|START_ENTITY assess|dobj|efficacy assess|nmod|patients patients|nmod|END_ENTITY	A randomized controlled trial to assess the efficacy and safety of doubling dose clopidogrel versus ticagrelor for the treatment of acute_coronary_syndrome in patients with CYP2C19 * 2 homozygotes .
26815196	0	clopidogrel	112,123	CYP2C19	11,18	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	inhibitors|amod|START_ENTITY co-administration|nmod|inhibitors test|nmod|co-administration -RSB-|dobj|test -RSB-|nsubj|Changes Changes|nmod|activity activity|nummod|END_ENTITY	Changes in CYP2C19 enzyme activity evaluated by the -LSB- -LRB- 13 -RRB- C -RSB- - pantoprazole breath test after co-administration of clopidogrel and proton pump inhibitors following percutaneous coronary intervention and correlation to platelet reactivity .
26971130	0	clopidogrel	14,25	CYP2C19	73,80	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	variability|amod|START_ENTITY Evaluation|nmod|variability Evaluation|nmod|polymorphism polymorphism|compound|END_ENTITY	Evaluation of clopidogrel response variability and identification of the CYP2C19 polymorphism in Mexican patients .
27042080	0	clopidogrel	112,123	CYP2C19	149,156	clopidogrel	CYP2C19	MESH:C055162	1557	Chemical	Gene	algorithm|amod|START_ENTITY implementation|nmod|algorithm supplemental|nmod|implementation supplemental|xcomp|comprising comprising|dobj|pharmacogenetics pharmacogenetics|compound|END_ENTITY	The use of oral suspension and rationally prescribing alternatives may be supplemental to the implementation of clopidogrel new algorithm comprising CYP2C19 pharmacogenetics and drug interactions .
24782221	0	clopidogrel	86,97	Cyp2c19	41,48	clopidogrel	Cyp2c19	MESH:C055162	1557	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY isoenzyme|nmod|pharmacokinetics isoenzyme|nsubj|influence influence|nmod|polymorphism polymorphism|nmod|END_ENTITY	The influence of genetic polymorphism of Cyp2c19 isoenzyme on the pharmacokinetics of clopidogrel and its metabolites in patients with cardiovascular_diseases .
24566733	0	clopidogrel	39,50	P-glycoprotein	73,87	clopidogrel	P-glycoprotein	MESH:C055162	5243	Chemical	Gene	START_ENTITY|nmod|modulation modulation|nmod|END_ENTITY	Aspirin decreases systemic exposure to clopidogrel through modulation of P-glycoprotein but does not alter its antithrombotic activity .
11773921	0	clopidogrel	26,37	P-selectin	76,86	clopidogrel	P-selectin	MESH:C055162	6403	Chemical	Gene	doses|amod|START_ENTITY doses|nmod|END_ENTITY	Effect of 300 - and 450-mg clopidogrel loading doses on membrane and soluble P-selectin in patients undergoing coronary stent implantation .
12353080	0	clopidogrel	94,105	P-selectin	26,36	clopidogrel	P-selectin	MESH:C055162	6403	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|expression expression|amod|END_ENTITY	Inhibition of ADP-induced P-selectin expression and platelet-leukocyte conjugate formation by clopidogrel and the P2Y12 receptor antagonist AR-C69931MX but not aspirin .
12714834	0	clopidogrel	136,147	P-selectin	20,30	clopidogrel	P-selectin	MESH:C055162	6403	Chemical	Gene	dose|nmod|START_ENTITY treated|nmod|dose treated|nsubj|Changes Changes|nmod|END_ENTITY	Changes in platelet P-selectin and in plasma C-reactive_protein in acute atherosclerotic ischemic_stroke treated with a loading dose of clopidogrel .
15968882	0	clopidogrel	175,186	P-selectin	0,10	clopidogrel	P-selectin	MESH:C055162	6403	Chemical	Gene	polymorphisms|parataxis|START_ENTITY polymorphisms|nsubj|END_ENTITY	P-selectin -LRB- CD62p -RRB- and P-selectin_glycoprotein_ligand-1 -LRB- PSGL-1 -RRB- polymorphisms : minor phenotypic differences in the formation of platelet-leukocyte aggregates and response to clopidogrel .
16928609	0	clopidogrel	18,29	P-selectin	62,72	clopidogrel	P-selectin	MESH:C055162	6403	Chemical	Gene	loading|amod|START_ENTITY Effects|nmod|loading Effects|nmod|expression expression|amod|END_ENTITY	Effects of ad hoc clopidogrel loading versus pre-treatment on P-selectin expression after coronary stent implantation .
19440925	0	clopidogrel	97,108	P-selectin	24,34	clopidogrel	P-selectin	MESH:C055162	6403	Chemical	Gene	aspirin|amod|START_ENTITY function|nmod|aspirin function|nsubj|Measurement Measurement|nmod|END_ENTITY	Measurement of platelet P-selectin for remote testing of platelet function during treatment with clopidogrel and/or aspirin .
21085001	0	clopidogrel	45,56	P-selectin	68,78	clopidogrel	P-selectin	MESH:C055162	6403	Chemical	Gene	doses|nmod|START_ENTITY Pretreatment|nmod|doses influences|nsubj|Pretreatment influences|dobj|levels levels|amod|END_ENTITY	Pretreatment with different loading doses of clopidogrel influences P-selectin levels in patients undergoing percutaneous coronary intervention : results from the ARMYDA-2 -LRB- antiplatelet therapy for reduction of myocardial_damage during angioplasty -RRB- SELECT substudy .
23940995	0	clopidogrel	40,51	P2RY12	0,6	clopidogrel	P2RY12	MESH:C055162	64805	Chemical	Gene	polymorphisms|nmod|START_ENTITY polymorphisms|nummod|END_ENTITY	P2RY12 gene polymorphisms and effect of clopidogrel on platelet_aggregation .
15199474	0	clopidogrel	46,57	P2Y12	0,5	clopidogrel	P2Y12	MESH:C055162	64805	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	P2Y12 , a new platelet ADP receptor , target of clopidogrel .
15795539	0	clopidogrel	128,139	P2Y12	0,5	clopidogrel	P2Y12	MESH:C055162	64805	Chemical	Gene	therapy|amod|START_ENTITY initiation|nmod|therapy platelet_aggregation|nmod|initiation associated|nmod|platelet_aggregation associated|nsubjpass|haplotype haplotype|compound|END_ENTITY	P2Y12 gene H2 haplotype is not associated with increased adenosine_diphosphate-induced platelet_aggregation after initiation of clopidogrel therapy with a high loading dose .
15967851	0	clopidogrel	101,112	P2Y12	78,83	clopidogrel	P2Y12	MESH:C055162	64805	Chemical	Gene	comparison|nmod|START_ENTITY comparison|appos|antagonist antagonist|compound|END_ENTITY	Randomized comparison of prasugrel -LRB- CS-747 , LY640315 -RRB- , a novel thienopyridine P2Y12 antagonist , with clopidogrel in percutaneous coronary intervention : results of the Joint Utilization of Medications to Block Platelets Optimally -LRB- JUMBO -RRB- - TIMI 26 trial .
16181985	0	clopidogrel	90,101	P2Y12	32,37	clopidogrel	P2Y12	MESH:C055162	64805	Chemical	Gene	Lack|acl|START_ENTITY Lack|nmod|association association|nmod|polymorphism polymorphism|compound|END_ENTITY	Lack of association between the P2Y12 receptor gene polymorphism and platelet response to clopidogrel in patients with coronary_artery_disease .
16423907	0	clopidogrel	17,28	P2Y12	99,104	clopidogrel	P2Y12	MESH:C055162	64805	Chemical	Gene	resistance|amod|START_ENTITY Determination|nmod|resistance platelet|nsubj|Determination platelet|dobj|aggregometry aggregometry|nmod|receptor receptor|compound|END_ENTITY	Determination of clopidogrel resistance by whole blood platelet aggregometry and inhibitors of the P2Y12 receptor .
16769602	0	clopidogrel	117,128	P2Y12	34,39	clopidogrel	P2Y12	MESH:C055162	64805	Chemical	Gene	therapy|amod|START_ENTITY effects|nmod|therapy explain|nmod|effects explain|nsubj|variations variations|nmod|genes genes|compound|END_ENTITY	Common sequence variations in the P2Y12 and CYP3A5 genes do not explain the variability in the inhibitory effects of clopidogrel therapy .
17076696	0	clopidogrel	99,110	P2Y12	68,73	clopidogrel	P2Y12	MESH:C055162	64805	Chemical	Gene	study|nmod|START_ENTITY study|appos|inhibitor inhibitor|compound|END_ENTITY	A multiple dose study of prasugrel -LRB- CS-747 -RRB- , a novel thienopyridine P2Y12 inhibitor , compared with clopidogrel in healthy humans .
17337040	0	clopidogrel	98,109	P2Y12	38,43	clopidogrel	P2Y12	MESH:C055162	64805	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|gene gene|compound|END_ENTITY	Role of the T744C polymorphism of the P2Y12 gene on platelet response to a 600-mg loading dose of clopidogrel in 597 patients with non-ST-segment elevation acute_coronary_syndrome .
17980251	0	clopidogrel	106,117	P2Y12	65,70	clopidogrel	P2Y12	MESH:C055162	64805	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|antagonist antagonist|compound|END_ENTITY	Inhibition of platelet_aggregation by AZD6140 , a reversible oral P2Y12 receptor antagonist , compared with clopidogrel in patients with acute_coronary_syndromes .
18577829	0	clopidogrel	109,120	P2Y12	28,33	clopidogrel	P2Y12	MESH:C055162	64805	Chemical	Gene	activation|nmod|START_ENTITY polymorphisms|acl|activation polymorphisms|nmod|genes genes|compound|END_ENTITY	Coexisting polymorphisms of P2Y12 and CYP2C19 genes as a risk factor for persistent platelet activation with clopidogrel .
19232433	0	clopidogrel	23,34	P2Y12	142,147	clopidogrel	P2Y12	MESH:C055162	64805	Chemical	Gene	interventions|amod|START_ENTITY effect|nmod|interventions effect|dep|inhibition inhibition|nmod|receptor receptor|compound|END_ENTITY	Antiplatelet effect of clopidogrel in patients with aspirin therapy undergoing percutaneous coronary interventions -- limited inhibition of the P2Y12 receptor .
19335707	0	clopidogrel	72,83	P2Y12	41,46	clopidogrel	P2Y12	MESH:C055162	64805	Chemical	Gene	risk|nmod|START_ENTITY risk|nmod|AZD6140 AZD6140|appos|antagonist antagonist|compound|END_ENTITY	Bleeding risk with AZD6140 , a reversible P2Y12 receptor antagonist , vs. clopidogrel in patients undergoing coronary artery bypass grafting in the DISPERSE2 trial .
20492465	0	clopidogrel	156,167	P2Y12	87,92	clopidogrel	P2Y12	MESH:C055162	64805	Chemical	Gene	leads|nmod|START_ENTITY leads|nmod|blockade blockade|compound|END_ENTITY	Potentiation of clopidogrel active metabolite formation by rifampicin leads to greater P2Y12 receptor blockade and inhibition of platelet_aggregation after clopidogrel .
20492465	0	clopidogrel	16,27	P2Y12	87,92	clopidogrel	P2Y12	MESH:C055162	64805	Chemical	Gene	formation|amod|START_ENTITY Potentiation|nmod|formation leads|nsubj|Potentiation leads|nmod|blockade blockade|compound|END_ENTITY	Potentiation of clopidogrel active metabolite formation by rifampicin leads to greater P2Y12 receptor blockade and inhibition of platelet_aggregation after clopidogrel .
20630458	0	clopidogrel	30,41	P2Y12	10,15	clopidogrel	P2Y12	MESH:C055162	64805	Chemical	Gene	angioplasty|amod|START_ENTITY inhibition|nmod|angioplasty inhibition|nsubj|Impact Impact|nmod|END_ENTITY	Impact of P2Y12 inhibition by clopidogrel on cardiovascular mortality in unselected patients treated by percutaneous coronary angioplasty : a prospective registry .
20800407	0	clopidogrel	28,39	P2Y12	4,9	clopidogrel	P2Y12	MESH:C055162	64805	Chemical	Gene	intervention|amod|START_ENTITY inhibitors|nmod|intervention inhibitors|nsubj|END_ENTITY	New P2Y12 inhibitors versus clopidogrel in percutaneous coronary intervention : a meta-analysis .
21251579	0	clopidogrel	156,167	P2Y12	136,141	clopidogrel	P2Y12	MESH:C055162	64805	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Cardiovascular_mortality in chronic_kidney_disease patients undergoing percutaneous coronary intervention is mainly related to impaired P2Y12 inhibition by clopidogrel .
21713327	0	clopidogrel	156,167	P2Y12	115,120	clopidogrel	P2Y12	MESH:C055162	64805	Chemical	Gene	blockade|nmod|START_ENTITY blockade|compound|END_ENTITY	Intrinsic platelet reactivity before P2Y12 blockade contributes to residual platelet reactivity despite high-level P2Y12 blockade by prasugrel or high-dose clopidogrel .
21713327	0	clopidogrel	156,167	P2Y12	37,42	clopidogrel	P2Y12	MESH:C055162	64805	Chemical	Gene	blockade|nmod|START_ENTITY contributes|nmod|blockade contributes|nsubj|reactivity reactivity|nmod|blockade blockade|compound|END_ENTITY	Intrinsic platelet reactivity before P2Y12 blockade contributes to residual platelet reactivity despite high-level P2Y12 blockade by prasugrel or high-dose clopidogrel .
22090660	0	clopidogrel	59,70	P2Y12	32,37	clopidogrel	P2Y12	MESH:C055162	64805	Chemical	Gene	START_ENTITY|nsubj|complications complications|nmod|antagonists antagonists|compound|END_ENTITY	Bleeding complications with the P2Y12 receptor antagonists clopidogrel and ticagrelor in the PLATelet inhibition and patient Outcomes -LRB- PLATO -RRB- trial .
22265638	0	clopidogrel	68,79	P2Y12	39,44	clopidogrel	P2Y12	MESH:C055162	64805	Chemical	Gene	variability|amod|START_ENTITY impact|nmod|variability impact|nmod|END_ENTITY	The impact of genetic polymorphisms of P2Y12 , CYP3A5 and CYP2C19 on clopidogrel response variability in Iranian patients .
22740070	0	clopidogrel	34,45	P2Y12	14,19	clopidogrel	P2Y12	MESH:C055162	64805	Chemical	Gene	patients|amod|START_ENTITY inhibition|nmod|patients inhibition|nummod|END_ENTITY	The extent of P2Y12 inhibition by clopidogrel in diabetes_mellitus patients with acute_coronary_syndrome is not related to glycaemic control : roles of white blood cell count and body weight .
23106905	0	clopidogrel	118,129	P2Y12	149,154	clopidogrel	P2Y12	MESH:C055162	64805	Chemical	Gene	cilostazol|dep|START_ENTITY therapy|appos|cilostazol comparison|nmod|therapy comparison|acl|using using|dobj|assay assay|nummod|END_ENTITY	Randomized comparison of new dual-antiplatelet therapy -LRB- aspirin , prasugrel -RRB- and triple-antiplatelet therapy -LRB- aspirin , clopidogrel , cilostazol -RRB- using P2Y12 point-of-care assay in patients with STEMI undergoing primary PCI .
23751603	0	clopidogrel	60,71	P2Y12	0,5	clopidogrel	P2Y12	MESH:C055162	64805	Chemical	Gene	effect|nmod|START_ENTITY polymorphism|dobj|effect polymorphism|nsubj|gene gene|nummod|END_ENTITY	P2Y12 receptor gene polymorphism and antiplatelet effect of clopidogrel in patients with coronary_artery_disease after coronary stenting .
23844259	0	clopidogrel	122,133	P2Y12	20,25	clopidogrel	P2Y12	MESH:C055162	64805	Chemical	Gene	monotherapy|amod|START_ENTITY receptor|nmod|monotherapy receptor|nsubj|Comparison Comparison|nmod|END_ENTITY	Comparison of a new P2Y12 receptor specific platelet_aggregation test with other laboratory methods in stroke patients on clopidogrel monotherapy .
24172891	0	clopidogrel	86,97	P2Y12	17,22	clopidogrel	P2Y12	MESH:C055162	64805	Chemical	Gene	effectively|nmod|START_ENTITY inhibit|advmod|effectively inhibit|nsubj|antagonists antagonists|compound|END_ENTITY	Third generation P2Y12 antagonists inhibit platelet_aggregation more effectively than clopidogrel in a myocardial_infarction registry .
24357254	0	clopidogrel	80,91	P2Y12	31,36	clopidogrel	P2Y12	MESH:C055162	64805	Chemical	Gene	therapy|amod|START_ENTITY receptor|nmod|therapy receptor|nsubj|Impact Impact|nmod|smoking smoking|nmod|END_ENTITY	Impact of cigarette smoking on P2Y12 receptor binding activity before and after clopidogrel therapy in patients with coronary_artery_disease .
24486281	0	clopidogrel	155,166	P2Y12	11,16	clopidogrel	P2Y12	MESH:C055162	64805	Chemical	Gene	impact|nmod|START_ENTITY inhibition|dep|impact inhibition|compound|END_ENTITY	Optimizing P2Y12 receptor inhibition in patients with acute_coronary_syndrome on the basis of platelet function testing : impact of prasugrel and high-dose clopidogrel .
24671606	0	clopidogrel	70,81	P2Y12	19,24	clopidogrel	P2Y12	MESH:C055162	64805	Chemical	Gene	overestimate|nmod|START_ENTITY overestimate|nsubj|assay assay|compound|END_ENTITY	Does the VerifyNow P2Y12 assay overestimate `` therapeutic response '' to clopidogrel ?
24745016	0	clopidogrel	68,79	P2Y12	15,20	clopidogrel	P2Y12	MESH:C055162	64805	Chemical	Gene	resistance|amod|START_ENTITY risk|nmod|resistance methylation|nmod|risk methylation|nsubj|Association Association|nmod|DNA DNA|compound|END_ENTITY	Association of P2Y12 gene promoter DNA methylation with the risk of clopidogrel resistance in coronary_artery_disease patients .
25012577	0	clopidogrel	28,39	P2Y12	90,95	clopidogrel	P2Y12	MESH:C055162	64805	Chemical	Gene	overcomes|nsubj|START_ENTITY overcomes|dobj|effect effect|nmod|inhibition inhibition|compound|END_ENTITY	Prasugrel but not high dose clopidogrel overcomes the lansoprazole neutralizing effect of P2Y12 inhibition : Results of the randomized DOSAPI study .
25190236	0	clopidogrel	66,77	P2Y12	40,45	clopidogrel	P2Y12	MESH:C055162	64805	Chemical	Gene	START_ENTITY|nsubj|responsiveness responsiveness|nmod|antagonist antagonist|compound|END_ENTITY	Impaired responsiveness to the platelet P2Y12 receptor antagonist clopidogrel in patients with type 2 diabetes and coronary_artery_disease .
25453411	0	clopidogrel	140,151	P2Y12	15,20	clopidogrel	P2Y12	MESH:C055162	64805	Chemical	Gene	receiving|xcomp|START_ENTITY intervention|acl|receiving genotype|nmod|intervention genotype|nsubj|Impact Impact|nmod|END_ENTITY	Impact of C34T P2Y12 genotype on endothelial function and arterial stiffness in patients after percutaneous coronary intervention receiving clopidogrel .
26092217	0	clopidogrel	10,21	P2Y12	67,72	clopidogrel	P2Y12	MESH:C055162	64805	Chemical	Gene	escalation|amod|START_ENTITY escalation|nmod|era era|nmod|END_ENTITY	Review of clopidogrel dose escalation in the current era of potent P2Y12 inhibitors .
26270719	0	clopidogrel	60,71	P2Y12	89,94	clopidogrel	P2Y12	MESH:C055162	64805	Chemical	Gene	metabolites|nmod|START_ENTITY binding|nmod|metabolites inhibits|dobj|binding inhibits|nmod|receptors receptors|nummod|END_ENTITY	Cangrelor inhibits the binding of the active metabolites of clopidogrel and prasugrel to P2Y12 receptors in vitro .
26340851	0	clopidogrel	66,77	P2Y12	25,30	clopidogrel	P2Y12	MESH:C055162	64805	Chemical	Gene	inhibitors|appos|START_ENTITY inhibitors|nummod|END_ENTITY	Antiplatelet efficacy of P2Y12 inhibitors -LRB- prasugrel , ticagrelor , clopidogrel -RRB- in patients treated with mild therapeutic_hypothermia after cardiac_arrest due to acute myocardial_infarction .
26610376	0	clopidogrel	179,190	P2Y12	135,140	clopidogrel	P2Y12	MESH:C055162	64805	Chemical	Gene	effective|nmod|START_ENTITY effective|nsubj|inhibitors inhibitors|compound|END_ENTITY	Stent thrombosis after primary percutaneous coronary intervention in comatose survivors of out-of-hospital cardiac_arrest : Are the new P2Y12 inhibitors really more effective than clopidogrel ?
12121059	0	clopidogrel	10,21	fibrinogen	74,84	clopidogrel	fibrinogen	MESH:C055162	2244	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of clopidogrel on platelet_aggregation and plasma concentration of fibrinogen in subjects with cerebral or coronary_atherosclerotic_disease .
18848137	0	clopidogrel	114,125	fibrinogen	16,26	clopidogrel	fibrinogen	MESH:C055162	2244	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	Elevated plasma fibrinogen and diabetes_mellitus are associated with lower inhibition of platelet reactivity with clopidogrel .
20624109	0	clopidogrel	95,106	fibrinogen	10,20	clopidogrel	fibrinogen	MESH:C055162	2244	Chemical	Gene	concentrate|nmod|START_ENTITY concentrate|nsubj|END_ENTITY	High-dose fibrinogen concentrate for haemostatic therapy of a major trauma patient with recent clopidogrel and aspirin intake .
10404775	0	clopidogrel	10,21	thrombin	25,33	clopidogrel	thrombin	MESH:C055162	29251(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|generation generation|compound|END_ENTITY	Effect of clopidogrel on thrombin generation in platelet-rich plasma in the rat .
16275997	0	cloretazine	74,85	O6-alkylguanine-DNA_alkyltransferase	8,44	cloretazine	O6-alkylguanine-DNA alkyltransferase	MESH:C483604	17314(Tax:10090)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of O6-alkylguanine-DNA_alkyltransferase in the cytotoxic activity of cloretazine .
1722343	0	clorgyline	84,94	MAO-A	67,72	clorgyline	MAO-A	MESH:D003010	29253(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	The response of the pineal melatonin biosynthesis to the selective MAO-A inhibitor , clorgyline , in young and middle-aged rats .
1203627	0	clorgyline	43,53	monoamine_oxidase	11,28	clorgyline	monoamine oxidase	MESH:D003010	29253(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|inhibition inhibition|amod|END_ENTITY	Effects of monoamine_oxidase inhibition by clorgyline , deprenil or tranylcypromine on 5-hydroxytryptamine concentrations in rat brain and hyperactivity following subsequent tryptophan administration .
6316394	0	clorgyline	52,62	monoamine_oxidase	20,37	clorgyline	monoamine oxidase	MESH:D003010	29253(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|Effect Effect|nmod|END_ENTITY	Effect of selective monoamine_oxidase inhibition by clorgyline and deprenyl on the norepinephrine receptor-coupled adenylate cyclase system in rat cortex .
6884911	0	clorgyline	71,81	monoamine_oxidase	23,40	clorgyline	monoamine oxidase	MESH:D003010	29253(Tax:10116)	Chemical	Gene	administration|nmod|START_ENTITY inhibition|nmod|administration inhibition|nmod|activity activity|amod|END_ENTITY	Regional inhibition of monoamine_oxidase activity by administration of clorgyline in rat brain .
8385528	0	clorgyline	56,66	monoamine_oxidase	27,44	clorgyline	monoamine oxidase	MESH:D003010	29253(Tax:10116)	Chemical	Gene	-LSB-|amod|START_ENTITY inhibitors|dobj|-LSB- inhibitors|nsubj|treatment treatment|nmod|END_ENTITY	Chronic treatment with the monoamine_oxidase inhibitors clorgyline and pargyline down-regulates non-adrenoceptor -LSB- 3H -RSB- - idazoxan binding sites in the rat brain .
9564611	0	clorgyline	103,113	monoamine_oxidase	73,90	clorgyline	monoamine oxidase	MESH:D003010	29253(Tax:10116)	Chemical	Gene	culture|amod|START_ENTITY culture|nmod|inhibitors inhibitors|amod|END_ENTITY	Modulation of glutamate neurotoxicity in the transformed cell culture by monoamine_oxidase inhibitors , clorgyline and deprenyl .
16794857	0	clorgyline	80,90	monoamine_oxidase-A	94,113	clorgyline	monoamine oxidase-A	MESH:D003010	17161(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Modification of morphine-induced hyperlocomotion and antinociception in mice by clorgyline , a monoamine_oxidase-A inhibitor .
15664686	0	clorgyline	65,75	monoamine_oxidase-a	79,98	clorgyline	monoamine oxidase-a	MESH:D003010	17161(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Inhibition of methamphetamine-induced hyperlocomotion in mice by clorgyline , a monoamine_oxidase-a inhibitor , through alteration of the 5-hydroxytriptamine turnover in the striatum .
14747710	0	clorgyline	100,110	monoamine_oxidase_A	65,84	clorgyline	monoamine oxidase A	MESH:D003010	29253(Tax:10116)	Chemical	Gene	complexed|nmod|START_ENTITY complexed|nsubj|analysis analysis|nmod|END_ENTITY	Crystallization and preliminary crystallographic analysis of rat monoamine_oxidase_A complexed with clorgyline .
17714093	0	clorgyline	102,112	monoamine_oxidase_A	116,135	clorgyline	monoamine oxidase A	MESH:D003010	29253(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Potentiation of 3,4-methylenedioxymethamphetamine-induced 5-HT release in the rat substantia nigra by clorgyline , a monoamine_oxidase_A inhibitor .
1893487	0	clorgyline	46,56	monoamine_oxidase_A	85,104	clorgyline	monoamine oxidase A	MESH:D003010	4128	Chemical	Gene	inhibition|amod|START_ENTITY Synthesis|nmod|inhibition Synthesis|nmod|END_ENTITY	Synthesis of fluorine and iodine analogues of clorgyline and selective inhibition of monoamine_oxidase_A .
19691856	0	clorgyline	50,60	monoamine_oxidase_A	64,83	clorgyline	monoamine oxidase A	MESH:D003010	4128	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Anti-oncogenic and pro-differentiation effects of clorgyline , a monoamine_oxidase_A inhibitor , on high grade prostate_cancer cells .
2365007	0	clorgyline	75,85	monoamine_oxidase_A	30,49	clorgyline	monoamine oxidase A	MESH:D003010	29253(Tax:10116)	Chemical	Gene	displacement|nmod|START_ENTITY Binding|dep|displacement Binding|nmod|-RSB- -RSB-|amod|brofaromine brofaromine|nmod|END_ENTITY	Binding of -LSB- 3H -RSB- brofaromine to monoamine_oxidase_A in vivo : displacement by clorgyline and moclobemide .
8832056	0	cloricromene	82,94	phospholipase_A2	112,128	cloricromene	phospholipase A2	MESH:C025945	151056	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|activation activation|amod|END_ENTITY	Inhibition of PAF synthesis by stimulated human polymorphonuclear leucocytes with cloricromene , an inhibitor of phospholipase_A2 activation .
10220488	0	clotrimazole	90,102	CYP3A	81,86	clotrimazole	CYP3A	MESH:D003022	1576	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Effect of inhibitor depletion on inhibitory potency : tight binding inhibition of CYP3A by clotrimazole .
3632706	0	clotrimazole	93,105	cytochrome_P-450	23,39	clotrimazole	cytochrome P-450	MESH:D003022	25251(Tax:10116)	Chemical	Gene	magnitude|xcomp|START_ENTITY magnitude|dobj|induction induction|amod|END_ENTITY	High magnitude hepatic cytochrome_P-450 induction by an N-substituted_imidazole antimycotic , clotrimazole .
12564641	0	clozapine	11,20	5-HT1A	91,97	clozapine	5-HT1A	MESH:D003024	24473(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|dep|role role|nmod|receptors receptors|nummod|END_ENTITY	Effects of clozapine on the efflux of serotonin and dopamine in the rat brain : the role of 5-HT1A receptors .
12589516	0	clozapine	33,42	5-HT1A	13,19	clozapine	5-HT1A	MESH:D003024	3350	Chemical	Gene	receptors|nmod|START_ENTITY receptors|nummod|END_ENTITY	Occupancy of 5-HT1A receptors by clozapine in the primate brain : a PET study .
15830225	0	clozapine	220,229	5-HT1A	173,179	clozapine	5-HT1A	MESH:D003024	24473(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY receptors|nmod|effects receptors|nummod|END_ENTITY	Comparison of the effects of clozapine and 8-hydroxy-2 - -LRB- di-n-propylamino -RRB- tetralin -LRB- 8-OH-DPAT -RRB- on progressive ratio schedule performance : evidence against the involvement of 5-HT1A receptors in the behavioural effects of clozapine .
15830225	0	clozapine	29,38	5-HT1A	173,179	clozapine	5-HT1A	MESH:D003024	24473(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY Comparison|nmod|effects Comparison|dep|evidence evidence|nmod|involvement involvement|nmod|receptors receptors|nummod|END_ENTITY	Comparison of the effects of clozapine and 8-hydroxy-2 - -LRB- di-n-propylamino -RRB- tetralin -LRB- 8-OH-DPAT -RRB- on progressive ratio schedule performance : evidence against the involvement of 5-HT1A receptors in the behavioural effects of clozapine .
9025114	0	clozapine	37,46	5-HT1A	0,6	clozapine	5-HT1A	MESH:D003024	24473(Tax:10116)	Chemical	Gene	lack|nmod:poss|START_ENTITY involved|nmod|lack involved|nsubjpass|receptors receptors|nummod|END_ENTITY	5-HT1A receptors are not involved in clozapine 's lack of cataleptogenic potential .
7564704	0	clozapine	57,66	5-HT2A_receptor	25,40	clozapine	5-HT2A receptor	MESH:D003024	3356	Chemical	Gene	variation|acl|START_ENTITY variation|nmod|END_ENTITY	Genetic variation of the 5-HT2A_receptor and response to clozapine .
7564705	0	clozapine	57,66	5-HT2A_receptor	25,40	clozapine	5-HT2A receptor	MESH:D003024	3356	Chemical	Gene	variation|acl|START_ENTITY variation|nmod|END_ENTITY	Genetic variation of the 5-HT2A_receptor and response to clozapine .
7564821	0	clozapine	53,62	5-HT2A_receptor	21,36	clozapine	5-HT2A receptor	MESH:D003024	3356	Chemical	Gene	variation|acl|START_ENTITY variation|nmod|END_ENTITY	Genetic variation of 5-HT2A_receptor and response to clozapine .
8678181	0	clozapine	104,113	5-HT2A_receptor	49,64	clozapine	5-HT2A receptor	MESH:D003024	3356	Chemical	Gene	Lack|acl|START_ENTITY Lack|nmod|association association|nmod|polymorphisms polymorphisms|nmod|gene gene|amod|END_ENTITY	Lack of association between polymorphisms in the 5-HT2A_receptor gene and the antipsychotic response to clozapine .
8916101	0	clozapine	86,95	5-HT2A_receptor	45,60	clozapine	5-HT2A receptor	MESH:D003024	3356	Chemical	Gene	Analysis|acl|START_ENTITY Analysis|nmod|polymorphism polymorphism|nmod|response response|amod|END_ENTITY	Analysis of a structural polymorphism in the 5-HT2A_receptor and clinical response to clozapine .
9491814	0	clozapine	126,135	5-HT2A_receptor	89,104	clozapine	5-HT2A receptor	MESH:D003024	3356	Chemical	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Evidence for association between polymorphisms in the promoter and coding regions of the 5-HT2A_receptor gene and response to clozapine .
14751426	0	clozapine	11,20	5-HT2_receptor	48,62	clozapine	5-HT2 receptor	MESH:D003024	3356	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|system system|amod|END_ENTITY	Effects of clozapine and its metabolites on the 5-HT2_receptor system in cortical and hippocampal cells in vitro .
7831432	0	clozapine	33,42	5-HT2_receptor	5,19	clozapine	5-HT2 receptor	MESH:D003024	3356	Chemical	Gene	occupancy|nmod|START_ENTITY occupancy|amod|END_ENTITY	High 5-HT2_receptor occupancy in clozapine treated patients demonstrated by PET .
11763009	0	clozapine	24,33	CYP1A2	65,71	clozapine	CYP1A2	MESH:D003024	1544	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Treatment-resistance to clozapine in association with ultrarapid CYP1A2 activity and the C -- > A polymorphism in intron 1 of the CYP1A2 gene : effect of grapefruit juice and low-dose fluvoxamine .
15206669	0	clozapine	15,24	CYP1A2	40,46	clozapine	CYP1A2	MESH:D003024	1544	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Nonresponse to clozapine and ultrarapid CYP1A2 activity : clinical data and analysis of CYP1A2 gene .
9384460	0	clozapine	58,67	CYP1A2	19,25	clozapine	CYP1A2	MESH:D003024	1544	Chemical	Gene	metabolism|nmod|START_ENTITY involvement|nmod|metabolism involvement|nmod|END_ENTITY	The involvement of CYP1A2 and CYP3A4 in the metabolism of clozapine .
18449897	0	clozapine	67,76	DRD3	28,32	clozapine	DRD3	MESH:D003024	1814	Chemical	Gene	Lack|acl|START_ENTITY Lack|nmod|association association|nmod|polymorphism polymorphism|compound|END_ENTITY	Lack of association between DRD3 gene polymorphism and response to clozapine in Turkish schizoprenia patients .
11443521	0	clozapine	117,126	GLT-1	40,45	clozapine	GLT-1	MESH:D003024	29482(Tax:10116)	Chemical	Gene	down-regulated|nmod|START_ENTITY down-regulated|nsubj|expression expression|nmod|END_ENTITY	The expression of glutamate transporter GLT-1 in the rat cerebral cortex is down-regulated by the antipsychotic drug clozapine .
14744169	0	clozapine	85,94	Prolactin	0,9	clozapine	Prolactin	MESH:D003024	5617	Chemical	Gene	treated|advcl|START_ENTITY treated|nsubj|levels levels|compound|END_ENTITY	Prolactin levels in schizophrenia and schizoaffective_disorder patients treated with clozapine , olanzapine , risperidone , or haloperidol .
19121361	0	clozapine	148,157	c-Fos	57,62	clozapine	c-Fos	MESH:D003024	14281(Tax:10090)	Chemical	Gene	implicated|nmod|START_ENTITY implicated|nsubj|Effects Effects|nmod|administration administration|nmod|regions regions|amod|MK-801 MK-801|nmod|expression expression|amod|END_ENTITY	Effects of acute and chronic administration of MK-801 on c-Fos protein expression in mice brain regions implicated in schizophrenia with or without clozapine .
10218801	0	clozapine	38,47	c-fos	61,66	clozapine	c-fos	MESH:D003024	14281(Tax:10090)	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Lack of a role for the D3 receptor in clozapine induction of c-fos demonstrated in D3 dopamine receptor-deficient mice .
9885784	0	clozapine	79,88	c-fos	59,64	clozapine	c-fos	MESH:D003024	2353	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|induction induction|nmod|expression expression|amod|END_ENTITY	Involvement of adenosine A2A receptors in the induction of c-fos expression by clozapine and haloperidol .
7752807	0	clozapine	29,38	dopamine_D4_receptor	42,62	clozapine	dopamine D4 receptor	MESH:D003024	1815	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|antagonist antagonist|amod|END_ENTITY	The antisecretory effects of clozapine , a dopamine_D4_receptor antagonist , are blocked by the dopamine_D1_receptor antagonist , SCH23390 .
8825892	0	clozapine	12,21	dopamine_D4_receptor	56,76	clozapine	dopamine D4 receptor	MESH:D003024	1815	Chemical	Gene	response|amod|START_ENTITY response|nmod|gene gene|amod|END_ENTITY	Analysis of clozapine response and polymorphisms of the dopamine_D4_receptor gene -LRB- DRD4 -RRB- in schizophrenic patients .
10428426	0	clozapine	109,118	fibroblast_growth_factor-2	24,50	clozapine	fibroblast growth factor-2	MESH:D003024	54250(Tax:10116)	Chemical	Gene	modulation|nmod|START_ENTITY modulation|nmod|expression expression|amod|END_ENTITY	Selective modulation of fibroblast_growth_factor-2 expression in the rat brain by the atypical antipsychotic clozapine .
16402076	0	clozapine	106,115	glucose-dependent_insulinotropic_polypeptide	43,87	clozapine	glucose-dependent insulinotropic polypeptide	MESH:D003024	25040(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY treatment|amod|END_ENTITY	cDNA array reveals increased expression of glucose-dependent_insulinotropic_polypeptide following chronic clozapine treatment : role in atypical antipsychotic drug-induced adverse metabolic effects .
24991150	0	clozapine	34,43	glucose_transporter-2	121,142	clozapine	glucose transporter-2	MESH:D003024	25351(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of combined treatment with clozapine and metformin on fasting blood_glucose , insulin level , and expression of the glucose_transporter-2 -LRB- GLUT2 -RRB- in Sprague-Dawley_rats .
20849150	0	clozapine	88,97	glutathione_S-transferases	14,40	clozapine	glutathione S-transferases	MESH:D003024	373156	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of human glutathione_S-transferases in the inactivation of reactive metabolites of clozapine .
19396726	0	clozapine	106,115	granulocyte_macrophage-colony_stimulating_factor	42,90	clozapine	granulocyte macrophage-colony stimulating factor	MESH:D003024	1437	Chemical	Gene	treatment|amod|START_ENTITY END_ENTITY|nmod|treatment	Circadian rhythm of neutrophil counts and granulocyte_macrophage-colony_stimulating_factor -LRB- GM-CSF -RRB- under clozapine treatment : a case report .
431802	0	clozapine	10,19	growth_hormone	43,57	clozapine	growth hormone	MESH:D003024	2688	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|amod|END_ENTITY	Effect of clozapine on apomorphine-induced growth_hormone secretion and serum prolactin concentrations in schizophrenia .
25554564	0	clozapine	27,36	interleukin_8	58,71	clozapine	interleukin 8	MESH:D003024	3576	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	The atypical antipsychotic clozapine selectively inhibits interleukin_8 -LRB- IL-8 -RRB- - induced neutrophil chemotaxis .
10441395	0	clozapine	13,22	myeloperoxidase	40,55	clozapine	myeloperoxidase	MESH:D003024	4353	Chemical	Gene	Oxidation|nmod|START_ENTITY Oxidation|nmod|END_ENTITY	Oxidation of clozapine and ascorbate by myeloperoxidase .
11147929	0	clozapine	66,75	myeloperoxidase	118,133	clozapine	myeloperoxidase	MESH:D003024	4353	Chemical	Gene	enzymes|amod|START_ENTITY agranulocytosis|nmod|enzymes agranulocytosis|dep|association association|nmod|P4502D6 P4502D6|amod|END_ENTITY	Clozapine-induced agranulocytosis and hereditary polymorphisms of clozapine metabolizing enzymes : no association with myeloperoxidase and cytochrome P4502D6 .
9243259	0	clozapine	14,23	myeloperoxidase	100,115	clozapine	myeloperoxidase	MESH:D003024	4353	Chemical	Gene	Metabolism|nmod|START_ENTITY Metabolism|dep|evidence evidence|nmod|oxidation oxidation|nmod|clozapine clozapine|nmod|system system|amod|END_ENTITY	Metabolism of clozapine by human neutrophils : evidence for a specific oxidation of clozapine by the myeloperoxidase system with inhibition of enzymatic chlorination cycle .
9243259	0	clozapine	83,92	myeloperoxidase	100,115	clozapine	myeloperoxidase	MESH:D003024	4353	Chemical	Gene	START_ENTITY|nmod|system system|amod|END_ENTITY	Metabolism of clozapine by human neutrophils : evidence for a specific oxidation of clozapine by the myeloperoxidase system with inhibition of enzymatic chlorination cycle .
11561931	0	clozapine	21,30	prolactin	48,57	clozapine	prolactin	MESH:D003024	5617	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Risperidone added to clozapine : impact on serum prolactin levels .
15365707	0	clozapine	105,114	prolactin	76,85	clozapine	prolactin	MESH:D003024	5617	Chemical	Gene	treatment|amod|START_ENTITY seen|nmod|treatment seen|nsubj|individual individual|nmod|increases increases|nmod|levels levels|compound|END_ENTITY	Possible individual and gender differences in the small increases in plasma prolactin levels seen during clozapine treatment .
507205	0	clozapine	10,19	prolactin	35,44	clozapine	prolactin	MESH:D003024	5617	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|compound|END_ENTITY	Effect of clozapine on human serum prolactin levels .
7831446	0	clozapine	83,92	prolactin	35,44	clozapine	prolactin	MESH:D003024	5617	Chemical	Gene	effect|nmod|START_ENTITY increase|dep|effect increase|nmod|secretion secretion|compound|END_ENTITY	The cimetidine-induced increase in prolactin secretion in schizophrenia : effect of clozapine .
9229404	0	clozapine	10,19	prolactin	54,63	clozapine	prolactin	MESH:D003024	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Effect of clozapine on dopamine-induced inhibition of prolactin release from cultured rat pituitary cells .
17561380	0	clozapine	17,26	translocator_protein	76,96	clozapine	translocator protein	MESH:D003024	24230(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|END_ENTITY	The influence of clozapine treatment and other antipsychotics on the 18 kDa translocator_protein , formerly named the peripheral-type_benzodiazepine_receptor , and steroid production .
14623371	0	clozapine	99,108	tumor_necrosis_factor_alpha	18,45	clozapine	tumor necrosis factor alpha	MESH:D003024	7124	Chemical	Gene	polymorphisms|xcomp|START_ENTITY polymorphisms|nsubj|association association|nmod|gene gene|compound|END_ENTITY	No association of tumor_necrosis_factor_alpha gene polymorphisms with schizophrenia or response to clozapine .
15824923	0	cnidiadin	94,103	MDR1	65,69	cnidiadin	MDR1	MESH:C502467	403879(Tax:9615)	Chemical	Gene	resistance|nmod|START_ENTITY resistance|compound|END_ENTITY	Inhibition of P-glycoprotein transport function and reversion of MDR1 multidrug resistance by cnidiadin .
212990	0	co-vidarabine	49,62	adenosine_deaminase	18,37	co-vidarabine	adenosine deaminase	MESH:D015649	11486(Tax:10090)	Chemical	Gene	co-V|amod|START_ENTITY Effect|dep|co-V Effect|nmod|inhibitor inhibitor|compound|END_ENTITY	Effect of a novel adenosine_deaminase inhibitor -LRB- co-vidarabine , co-V -RRB- upon the antiviral activity in vitro and in vivo of vidarabine -LRB- Vira-Atm -RRB- for DNA virus replication .
280160	0	co-vidarabine	37,50	adenosine_deaminase	14,33	co-vidarabine	adenosine deaminase	MESH:D015649	100	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of adenosine_deaminase by co-vidarabine and its effect on the metabolic disposition of adenine_arabinoside -LRB- vidarabine -RRB- .
12873151	1	cobalamin	219,228	Cbl	256,259	cobalamin	Cbl	MESH:D014805	867	Chemical	Gene	-RSB-|amod|START_ENTITY -RSB-|compound|END_ENTITY	Despite early claims that nitric_oxide does not react with cobalamin under any circumstances , it is now accepted that NO has a high affinity for cobalamin in the 2 + oxidation state -LSB- Cbl -LRB- II -RRB- -RSB- .
11287214	0	cobalamin	12,21	intrinsic_factor	27,43	cobalamin	intrinsic factor	MESH:D014805	2694	Chemical	Gene	Transfer|nmod|START_ENTITY Transfer|nmod|END_ENTITY	Transfer of cobalamin from intrinsic_factor to transcobalamin_II .
1331073	0	cobalamin	26,35	intrinsic_factor	4,20	cobalamin	intrinsic factor	MESH:D014805	2694	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|dep|receptor	The intrinsic_factor -LRB- IF -RRB- - cobalamin receptor binding site is located in the amino-terminal portion of IF .
10444342	0	cobalamin	68,77	methionine_synthase_reductase	20,49	cobalamin	methionine synthase reductase	MESH:D014805	4552	Chemical	Gene	combined|nmod|START_ENTITY END_ENTITY|acl|combined	A common variant in methionine_synthase_reductase combined with low cobalamin -LRB- vitamin_B12 -RRB- increases risk for spina_bifida .
11287214	0	cobalamin	12,21	transcobalamin_II	47,64	cobalamin	transcobalamin II	MESH:D014805	6948	Chemical	Gene	Transfer|nmod|START_ENTITY Transfer|nmod|END_ENTITY	Transfer of cobalamin from intrinsic_factor to transcobalamin_II .
11688986	0	cobalt	41,47	Hypoxia-inducible_factor_2alpha	0,31	cobalt	Hypoxia-inducible factor 2alpha	MESH:D003035	2034	Chemical	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	Hypoxia-inducible_factor_2alpha binds to cobalt in vitro .
6745235	0	cobalt	68,74	Lysozyme	0,8	cobalt	Lysozyme	MESH:D003035	100340903(Tax:9986)	Chemical	Gene	levels|nmod|START_ENTITY levels|amod|END_ENTITY	Lysozyme levels in rabbit lung after inhalation of nickel , cadmium , cobalt , and copper chlorides .
15878362	0	cobalt	10,16	TIMP-1	45,51	cobalt	TIMP-1	MESH:D003035	7076	Chemical	Gene	ions|compound|START_ENTITY ions|nmod|END_ENTITY	Effect of cobalt and chromium ions on MMP-1 , TIMP-1 , and TNF-alpha gene expression in human U937 macrophages : a role for tyrosine kinases .
24486411	0	cobalt	27,33	Yap1	0,4	cobalt	Yap1	MESH:D003035	855005(Tax:4932)	Chemical	Gene	mediates|advcl|START_ENTITY mediates|nsubj|END_ENTITY	Yap1 mediates tolerance to cobalt toxicity in the yeast Saccharomyces_cerevisiae .
1994904	0	cobalt	19,25	coumarin_7-hydroxylase	70,92	cobalt	coumarin 7-hydroxylase	MESH:D003035	13087(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Comparison between cobalt and pyrazole in the increased expression of coumarin_7-hydroxylase in mouse liver .
7115319	0	cobalt	40,46	cytochrome_P-450	20,36	cobalt	cytochrome P-450	MESH:D003035	25251(Tax:10116)	Chemical	Gene	Decrease|nmod|START_ENTITY Decrease|nmod|END_ENTITY	Decrease in hepatic cytochrome_P-450 by cobalt .
805210	0	cobalt	82,88	cytochrome_P-450	92,108	cobalt	cytochrome P-450	MESH:D003035	25251(Tax:10116)	Chemical	Gene	Study|nmod|START_ENTITY Study|nmod|END_ENTITY	Study of the developmental pattern of heme catabolism in liver and the effects of cobalt on cytochrome_P-450 and the rate of heme oxidation during the neonatal period .
4717751	0	cobalt	94,100	erythropoietin	37,51	cobalt	erythropoietin	MESH:D003035	443302(Tax:9940)	Chemical	Gene	thereon|amod|START_ENTITY Studies|nmod|thereon Studies|nmod|formation formation|nmod|END_ENTITY	Studies on the in vitro formation of erythropoietin in sheep kidney medulla and the effect of cobalt thereon .
5895765	2	cobalt	89,95	erythropoietin	60,74	cobalt	erythropoietin	MESH:D003035	2056	Chemical	Gene	-RSB-|amod|START_ENTITY Studies|nmod|-RSB- Studies|nmod|mechanism mechanism|nmod|production production|compound|END_ENTITY	Studies on the mechanism of erythropoietin production by cobalt -RSB- .
5918120	0	cobalt	11,17	erythropoietin	39,53	cobalt	erythropoietin	MESH:D003035	443302(Tax:9940)	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	Effects of cobalt on activity of sheep erythropoietin in rat kidney homogenates .
8011627	0	cobalt-substituted_distal_histidine	59,94	myoglobin	112,121	cobalt-substituted distal histidine	myoglobin	null	4151	Chemical	Gene	mutants|amod|START_ENTITY mutants|nmod|END_ENTITY	Electron-nuclear coupling to the proximal histidine in oxy cobalt-substituted_distal_histidine mutants of human myoglobin .
20594416	0	cobalt_chloride	30,45	EC-SOD	67,73	cobalt chloride	EC-SOD	MESH:C018021	6649	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	The effect of hypoxia mimetic cobalt_chloride on the expression of EC-SOD in 3T3-L1 adipocytes .
17082639	0	cobalt_chloride	44,59	IL-8	96,100	cobalt chloride	IL-8	MESH:C018021	3576	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	A novel role of hypoxia-inducible factor in cobalt_chloride - and hypoxia-mediated expression of IL-8 chemokine in human endothelial cells .
19073570	0	cobalt_chloride	11,26	S100A4	30,36	cobalt chloride	S100A4	MESH:C018021	6275	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	-LSB- Effect of cobalt_chloride on S100A4 expression in human gastric_cancer cell BGC823 -RSB- .
21804221	0	cobalt_chloride	26,41	extracellular-superoxide_dismutase	63,97	cobalt chloride	extracellular-superoxide dismutase	MESH:C018021	6649	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effect of hypoxia mimetic cobalt_chloride on the expression of extracellular-superoxide_dismutase in retinal pericytes .
16427735	0	cobalt_chloride	63,78	hypoxia-inducible_factor-1alpha	13,44	cobalt chloride	hypoxia-inducible factor-1alpha	MESH:C018021	3091	Chemical	Gene	overexpression|nmod|START_ENTITY overexpression|amod|END_ENTITY	Induction of hypoxia-inducible_factor-1alpha overexpression by cobalt_chloride enhances cellular resistance to photodynamic therapy .
24059959	0	cobalt_chloride	72,87	integrin-linked_kinase	15,37	cobalt chloride	integrin-linked kinase	MESH:C018021	3611	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Expression Expression|nmod|END_ENTITY	-LSB- Expression of integrin-linked_kinase in fibroblasts of scar induced by cobalt_chloride and its effect on cell proliferation -RSB- .
2605669	0	cobalt_chloride	82,97	ornithine_decarboxylase	37,60	cobalt chloride	ornithine decarboxylase	MESH:C018021	24609(Tax:10116)	Chemical	Gene	doses|nmod|START_ENTITY END_ENTITY|nmod|doses	Synergistic induction of rat hepatic ornithine_decarboxylase by multiple doses of cobalt_chloride .
14583137	0	cobalt_chloride	86,101	vascular_endothelial_growth_factor	37,71	cobalt chloride	vascular endothelial growth factor	MESH:C018021	100008899(Tax:9986)	Chemical	Gene	suppressed|nmod|START_ENTITY suppressed|dobj|upregulation upregulation|nmod|expression expression|compound|END_ENTITY	Genistein suppressed upregulation of vascular_endothelial_growth_factor expression by cobalt_chloride and hypoxia in rabbit retinal_pigment_epithelium cells .
22044301	0	cobalt_chloride	57,72	vascular_endothelial_growth_factor	76,110	cobalt chloride	vascular endothelial growth factor	MESH:C018021	7422	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Oxygen as a regulator of MA-10 cell functions : effect of cobalt_chloride on vascular_endothelial_growth_factor production .
23853521	0	cobalt_porphyrins	50,67	cytochrome_P450	71,86	cobalt porphyrins	cytochrome P450	null	4051	Chemical	Gene	START_ENTITY|nmod|model model|amod|END_ENTITY	Synthesis and catalytic properties of a series of cobalt_porphyrins as cytochrome_P450 model : the effect of substituents on the catalytic activity .
25436953	0	cobalt_protoporphyrin	30,51	Heme_oxygenase-1	0,16	cobalt protoporphyrin	Heme oxygenase-1	MESH:C007095	24451(Tax:10116)	Chemical	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Heme_oxygenase-1 induction by cobalt_protoporphyrin enhances fever and inhibits pyrogenic tolerance to lipopolysaccharide .
17065227	0	cobalt_protoporphyrin	72,93	heme_oxygenase-1	47,63	cobalt protoporphyrin	heme oxygenase-1	MESH:C007095	3162	Chemical	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Role of Bach1 and Nrf2 in up-regulation of the heme_oxygenase-1 gene by cobalt_protoporphyrin .
19554654	0	cobalt_protoporphyrin	77,98	heme_oxygenase-1	13,29	cobalt protoporphyrin	heme oxygenase-1	MESH:C007095	24451(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Influence Influence|nmod|expression expression|amod|END_ENTITY	Influence of heme_oxygenase-1 expression on immune liver fibrosis induced by cobalt_protoporphyrin in rats .
21129280	0	cobalt_protoporphyrin	11,32	heme_oxygenase-1	55,71	cobalt protoporphyrin	heme oxygenase-1	MESH:C007095	24451(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|hyperexpression hyperexpression|nmod|END_ENTITY	-LSB- Effect of cobalt_protoporphyrin on hyperexpression of heme_oxygenase-1 and secretion of IL-10 in rat bone marrow mesenchymal stem cells -RSB- .
21275512	0	cobalt_protoporphyrin	44,65	heme_oxygenase-1	74,90	cobalt protoporphyrin	heme oxygenase-1	MESH:C007095	24451(Tax:10116)	Chemical	Gene	preconditioning|nmod|START_ENTITY Pharmacological|acl|preconditioning induces|nsubj|Pharmacological induces|dobj|overexpression overexpression|amod|END_ENTITY	Pharmacological preconditioning by low dose cobalt_protoporphyrin induces heme_oxygenase-1 overexpression and alleviates retinal_ischemia-reperfusion_injury in rats .
2070790	0	cobamide	43,51	intrinsic_factor	106,122	cobamide	intrinsic factor	CHEBI:3796	2694	Chemical	Gene	recognition|amod|START_ENTITY recognition|nmod|END_ENTITY	Effect of the cobalt-N coordination on the cobamide recognition by the human vitamin_B12 binding proteins intrinsic_factor , transcobalamin and haptocorrin .
8208757	0	cocaine	88,95	5-HT3_receptor	0,14	cocaine	5-HT3 receptor	MESH:D003042	79246(Tax:10116)	Chemical	Gene	modulation|nmod|START_ENTITY modulation|amod|END_ENTITY	5-HT3_receptor modulation of behavior during withdrawal from continuous or intermittent cocaine .
1329800	0	cocaine	40,47	ACTH	72,76	cocaine	ACTH	MESH:D003042	5443	Chemical	Gene	effects|nmod|START_ENTITY attenuates|dobj|effects attenuates|nmod|secretion secretion|appos|END_ENTITY	Buprenorphine attenuates the effects of cocaine on adrenocorticotropin -LRB- ACTH -RRB- secretion and mood states in man .
1338055	0	cocaine	73,80	ACTH	29,33	cocaine	ACTH	MESH:D003042	5443	Chemical	Gene	addicts|compound|START_ENTITY variations|nmod|addicts variations|nmod|END_ENTITY	Diurnal variations in plasma ACTH , cortisol and beta-endorphin levels in cocaine addicts .
21490206	0	cocaine	29,36	AKAP	0,4	cocaine	AKAP	MESH:D003042	498549(Tax:10116)	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	AKAP signaling in reinstated cocaine seeking revealed by iTRAQ proteomic analysis .
12784114	0	cocaine	30,37	BDNF	89,93	cocaine	BDNF	MESH:D003042	12064(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Reduced behavioral effects of cocaine in heterozygous brain-derived_neurotrophic_factor -LRB- BDNF -RRB- knockout mice .
15671872	0	cocaine	9,16	BDNF	36,40	cocaine	BDNF	MESH:D003042	24225(Tax:10116)	Chemical	Gene	exposure|compound|START_ENTITY increases|nsubj|exposure increases|dobj|END_ENTITY	A single cocaine exposure increases BDNF and D3 receptor expression : implications for drug-conditioning .
16423334	0	cocaine	66,73	BDNF	15,19	cocaine	BDNF	MESH:D003042	24225(Tax:10116)	Chemical	Gene	treatments|compound|START_ENTITY mRNAs|nmod|treatments mRNAs|nsubj|Alterations Alterations|nmod|END_ENTITY	Alterations in BDNF and trkB mRNAs following acute or sensitizing cocaine treatments and withdrawal .
17618281	0	cocaine	48,55	BDNF	8,12	cocaine	BDNF	MESH:D003042	24225(Tax:10116)	Chemical	Gene	use|compound|START_ENTITY accumbens|nmod|use activity|nmod|accumbens activity|compound|END_ENTITY	Dynamic BDNF activity in nucleus accumbens with cocaine use increases self-administration and relapse .
17651427	0	cocaine	61,68	BDNF	2,6	cocaine	BDNF	MESH:D003042	24225(Tax:10116)	Chemical	Gene	suppresses|dobj|START_ENTITY suppresses|nsubj|infusion infusion|amod|END_ENTITY	A BDNF infusion into the medial prefrontal cortex suppresses cocaine seeking in rats .
18001273	0	cocaine	21,28	BDNF	51,55	cocaine	BDNF	MESH:D003042	24225(Tax:10116)	Chemical	Gene	exposure|nmod|START_ENTITY modulates|nsubj|exposure modulates|dobj|mRNA mRNA|compound|END_ENTITY	Repeated exposure to cocaine differently modulates BDNF mRNA and protein levels in rat striatum and prefrontal cortex .
18946637	0	cocaine	52,59	BDNF	6,10	cocaine	BDNF	MESH:D003042	627	Chemical	Gene	addicts|compound|START_ENTITY expressed|nmod|addicts expressed|nsubjpass|isoforms isoforms|compound|END_ENTITY	Human BDNF isoforms are differentially expressed in cocaine addicts and are sorted to the regulated secretory pathway independent of the Met66 substitution .
20810894	4	cocaine	717,724	BDNF	868,872	cocaine	BDNF	MESH:D003042	24225(Tax:10116)	Chemical	Gene	self-administration|compound|START_ENTITY assessed|nsubjpass|self-administration assessed|nmod|suppression suppression|nmod|expression expression|compound|END_ENTITY	To examine the functional relevance of this finding , cocaine self-administration maintained under a progressive ratio schedule of reinforcement was assessed after short hairpin RNA-induced suppression of BDNF expression in the mPFC .
20826313	0	cocaine	20,27	BDNF	9,13	cocaine	BDNF	MESH:D003042	24225(Tax:10116)	Chemical	Gene	withdrawal|compound|START_ENTITY END_ENTITY|nmod|withdrawal	Elevated BDNF after cocaine withdrawal facilitates LTP in medial prefrontal cortex by suppressing GABA inhibition .
20947769	0	cocaine	72,79	BDNF	27,31	cocaine	BDNF	MESH:D003042	627	Chemical	Gene	reward|compound|START_ENTITY control|nmod|reward mimics|dobj|control mimics|nsubj|loss loss|nmod|signaling signaling|compound|END_ENTITY	Cell type-specific loss of BDNF signaling mimics optogenetic control of cocaine reward .
22043863	0	cocaine	99,106	BDNF	170,174	cocaine	BDNF	MESH:D003042	24225(Tax:10116)	Chemical	Gene	abstinence|compound|START_ENTITY expression|nmod|abstinence brain-derived_neurotrophic_factor|acl|expression associated|nsubjpass|brain-derived_neurotrophic_factor associated|nmod|acetylation acetylation|nmod|promoters promoters|compound|END_ENTITY	Increased brain-derived_neurotrophic_factor -LRB- BDNF -RRB- expression in the ventral tegmental area during cocaine abstinence is associated with increased histone acetylation at BDNF exon I-containing promoters .
22043863	0	cocaine	99,106	BDNF	45,49	cocaine	BDNF	MESH:D003042	24225(Tax:10116)	Chemical	Gene	abstinence|compound|START_ENTITY expression|nmod|abstinence brain-derived_neurotrophic_factor|acl|expression brain-derived_neurotrophic_factor|appos|END_ENTITY	Increased brain-derived_neurotrophic_factor -LRB- BDNF -RRB- expression in the ventral tegmental area during cocaine abstinence is associated with increased histone acetylation at BDNF exon I-containing promoters .
23164369	0	cocaine	78,85	BDNF	27,31	cocaine	BDNF	MESH:D003042	24225(Tax:10116)	Chemical	Gene	self-administration|compound|START_ENTITY effects|nmod|self-administration effects|nmod|expression expression|compound|END_ENTITY	Region-specific effects on BDNF expression after contingent or non-contingent cocaine i.v. self-administration in rats .
23239946	0	cocaine	33,40	BDNF	14,18	cocaine	BDNF	MESH:D003042	627	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of BDNF expression by cocaine .
23325250	0	cocaine	100,107	BDNF	19,23	cocaine	BDNF	MESH:D003042	24225(Tax:10116)	Chemical	Gene	craving|compound|START_ENTITY incubation|nmod|craving accumbens|nmod|incubation accumbens|nsubj|roles roles|nmod|END_ENTITY	Different roles of BDNF in nucleus accumbens core versus shell during the incubation of cue-induced cocaine craving and its long-term maintenance .
23333681	0	cocaine	70,77	BDNF	107,111	cocaine	BDNF	MESH:D003042	24225(Tax:10116)	Chemical	Gene	pre-exposure|nmod|START_ENTITY behavior|nmod|pre-exposure accompanied|nsubjpass|behavior accompanied|nmod|changes changes|nmod|END_ENTITY	Enhanced nicotine-seeking behavior following pre-exposure to repeated cocaine is accompanied by changes in BDNF in the nucleus accumbens of rats .
24345425	0	cocaine	40,47	BDNF	70,74	cocaine	BDNF	MESH:D003042	24225(Tax:10116)	Chemical	Gene	exposure|compound|START_ENTITY abstinence|nmod|exposure dysregulates|nsubj|abstinence dysregulates|dobj|END_ENTITY	Prolonged abstinence from developmental cocaine exposure dysregulates BDNF and its signaling network in the medial prefrontal cortex of adult rats .
24676990	0	cocaine	72,79	BDNF	21,25	cocaine	BDNF	MESH:D003042	627	Chemical	Gene	severity|nmod|START_ENTITY markers|nmod|severity END_ENTITY|nmod|markers	Oxidative stress and BDNF as possible markers for the severity of crack cocaine use in early withdrawal .
25522421	0	cocaine	53,60	BDNF	34,38	cocaine	BDNF	MESH:D003042	24225(Tax:10116)	Chemical	Gene	withdrawal|compound|START_ENTITY levels|nmod|withdrawal levels|compound|END_ENTITY	Temporal regulation of peripheral BDNF levels during cocaine and morphine withdrawal : comparison with a natural reward .
26923993	0	cocaine	46,53	BDNF	20,24	cocaine	BDNF	MESH:D003042	627	Chemical	Gene	key|nmod|START_ENTITY END_ENTITY|dep|key	Prefrontal cortical BDNF : A regulatory key in cocaine - and food-reinforced behaviors .
8319761	0	cocaine	82,89	C-fos	0,5	cocaine	C-fos	MESH:D003042	314322(Tax:10116)	Chemical	Gene	action|nmod|START_ENTITY blocks|dobj|action blocks|nsubj|antisense antisense|amod|END_ENTITY	C-fos antisense in the nucleus accumbens blocks the locomotor stimulant action of cocaine .
9682220	0	cocaine	15,22	C-fos	0,5	cocaine	C-fos	MESH:D003042	314322(Tax:10116)	Chemical	Gene	inhibition|compound|START_ENTITY mediates|dobj|inhibition mediates|nsubj|END_ENTITY	C-fos mediates cocaine inhibition of NGF-induced PC12 cell differentiation .
11085307	0	cocaine	50,57	C-fos_and_egr-1	0,15	cocaine	C-fos and egr-1	MESH:D003042	314322;24330	Chemical	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	C-fos_and_egr-1 immediate-early gene induction by cocaine and cocaethylene in rat brain : a comparative study .
10599860	0	cocaine	74,81	CART	41,45	cocaine	CART	MESH:D003042	29131(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY differences|dep|effects differences|nmod|expression expression|compound|END_ENTITY	Mesolimbic gender differences in peptide CART mRNA expression : effects of cocaine .
10612702	0	cocaine	13,20	CART	60,64	cocaine	CART	MESH:D003042	27220(Tax:10090)	Chemical	Gene	START_ENTITY|dep|and_amphetamine-regulated_transcript and_amphetamine-regulated_transcript|appos|END_ENTITY	Hypothalamic cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- neurons : histochemical relationship to thyrotropin-releasing_hormone , melanin-concentrating hormone , orexin/hypocretin and neuropeptide_Y .
10975881	0	cocaine	6,13	CART	53,57	cocaine	CART	MESH:D003042	9607	Chemical	Gene	START_ENTITY|dep|and_amphetamine-regulated_transcript and_amphetamine-regulated_transcript|appos|END_ENTITY	Human cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- mRNA is highly expressed in limbic - and sensory-related brain regions .
11223006	0	cocaine	11,18	CART	58,62	cocaine	CART	MESH:D003042	29131(Tax:10116)	Chemical	Gene	Actions|nmod|START_ENTITY Actions|dep|peptide peptide|appos|END_ENTITY	Actions of cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- peptide on regulation of appetite and hypothalamo-pituitary axes in vitro and in vivo in male rats .
11713200	0	cocaine	33,40	CART	80,84	cocaine	CART	MESH:D003042	9607	Chemical	Gene	transcript|amod|START_ENTITY transcript|appos|END_ENTITY	Characterization of two forms of cocaine - and amphetamine-regulated transcript -LRB- CART -RRB- peptide precursors in goldfish : molecular cloning and distribution , modulation of expression by nutritional status , and interactions with leptin .
11714891	0	cocaine	31,38	CART	102,106	cocaine	CART	MESH:D003042	27220(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nsubj|effects	Multiple behavioral effects of cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- peptides in mice : CART 42-89 and CART 49-89 differ in potency and activity .
11714891	0	cocaine	31,38	CART	78,82	cocaine	CART	MESH:D003042	27220(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|acl|_ _|dobj|peptides peptides|appos|END_ENTITY	Multiple behavioral effects of cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- peptides in mice : CART 42-89 and CART 49-89 differ in potency and activity .
11948252	0	cocaine	24,31	CART	71,75	cocaine	CART	MESH:D003042	29131(Tax:10116)	Chemical	Gene	Characterization|nmod|START_ENTITY Characterization|dep|promoter promoter|appos|END_ENTITY	Characterization of the cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- peptide gene promoter and its activation by a cyclic_AMP-dependent signaling pathway in GH3 cells .
12933358	1	cocaine	183,190	CART	230,234	cocaine	CART	MESH:D003042	29131(Tax:10116)	Chemical	Gene	origin|nmod|START_ENTITY origin|dep|fibers fibers|appos|END_ENTITY	The present study was undertaken to investigate the origin of cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- peptide immunoreactive -LRB- irCART -RRB- fibers observed in the nucleus of the solitary tract -LRB- NTS -RRB- and assess the role of CART peptide on phenylephrine -LRB- PE -RRB- - induced baroreflex .
14691017	2	cocaine	431,438	CART	478,482	cocaine	CART	MESH:D003042	29131(Tax:10116)	Chemical	Gene	START_ENTITY|dep|and_amphetamine-regulated_transcript and_amphetamine-regulated_transcript|appos|END_ENTITY	Recent data from our laboratories have demonstrated that TRH and cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- are co-contained only in hypophysiotropic neurons in the PVN .
14730586	0	cocaine	10,17	CART	57,61	cocaine	CART	MESH:D003042	29131(Tax:10116)	Chemical	Gene	Origin|nmod|START_ENTITY Origin|dep|and_amphetamine-regulated_transcript and_amphetamine-regulated_transcript|appos|END_ENTITY	Origin of cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- - immunoreactive innervation of the hypothalamic paraventricular nucleus .
15138156	0	cocaine	28,35	CART	75,79	cocaine	CART	MESH:D003042	29131(Tax:10116)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|dep|and_amphetamine-regulated_transcript and_amphetamine-regulated_transcript|appos|END_ENTITY	Regulation of rat pituitary cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- by CRH and glucocorticoids .
15680956	0	cocaine	52,59	CART	99,103	cocaine	CART	MESH:D003042	9607	Chemical	Gene	afferents|nmod|START_ENTITY contribution|nmod|afferents contribution|dep|innervation innervation|appos|END_ENTITY	Relative contribution of brainstem afferents to the cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- innervation of thyrotropin-releasing_hormone synthesizing neurons in the hypothalamic paraventricular nucleus -LRB- PVN -RRB- .
15726016	0	cocaine	19,26	CART	66,70	cocaine	CART	MESH:D003042	29131(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|and_amphetamine-regulated_transcript and_amphetamine-regulated_transcript|appos|END_ENTITY	The main effect of cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- peptide on hypothalamic neuronal activity depends on the nutritional state of rats .
15890775	0	cocaine	13,20	CART	60,64	cocaine	CART	MESH:D003042	29131(Tax:10116)	Chemical	Gene	START_ENTITY|parataxis|coexpress coexpress|nsubj|and_amphetamine-regulated_transcript and_amphetamine-regulated_transcript|appos|END_ENTITY	Hypothalamic cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- and agouti-related_protein -LRB- AgRP -RRB- neurons coexpress the NOP1 receptor and nociceptin alters CART and AgRP release .
15972209	0	cocaine	15,22	CART	26,30	cocaine	CART	MESH:D003042	29131(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	The effects of cocaine on CART expression in the rat nucleus accumbens : a possible role for corticosterone .
16102267	0	cocaine	23,30	CART	70,74	cocaine	CART	MESH:D003042	9607	Chemical	Gene	role|nmod|START_ENTITY role|dep|and_amphetamine-regulated_transcript and_amphetamine-regulated_transcript|appos|END_ENTITY	Dissecting the role of cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- in the control of appetite .
16210370	0	cocaine	39,46	CART	86,90	cocaine	CART	MESH:D003042	9607	Chemical	Gene	leads|nmod|START_ENTITY leads|dep|_ _|dep|deficiency deficiency|appos|END_ENTITY	The Leu34Phe ProCART mutation leads to cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- deficiency : a possible cause for obesity in humans .
16309793	0	cocaine	37,44	CART	84,88	cocaine	CART	MESH:D003042	27220(Tax:10090)	Chemical	Gene	Characterization|nmod|START_ENTITY Characterization|dep|and_amphetamine-regulated_transcript and_amphetamine-regulated_transcript|appos|END_ENTITY	Characterization and localization of cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- binding sites .
16705679	0	cocaine	64,71	CART	111,115	cocaine	CART	MESH:D003042	29131(Tax:10116)	Chemical	Gene	thalamus|nmod|START_ENTITY nucleus|nmod|thalamus Innervation|nmod|nucleus Innervation|dep|and_amphetamine-regulated_transcript and_amphetamine-regulated_transcript|appos|END_ENTITY	Innervation of the paraventricular nucleus of the thalamus from cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- containing neurons of the hypothalamus .
16730860	0	cocaine	56,63	CART	103,107	cocaine	CART	MESH:D003042	9607	Chemical	Gene	association|nmod|START_ENTITY implications|nmod|association implications|dep|and_amphetamine_regulated_transcript and_amphetamine_regulated_transcript|appos|END_ENTITY	Neuroendocrine implications for the association between cocaine - _ and_amphetamine_regulated_transcript -LRB- CART -RRB- and hypophysiotropic thyrotropin-releasing_hormone -LRB- TRH -RRB- .
16762458	0	cocaine	11,18	CART	58,62	cocaine	CART	MESH:D003042	27220(Tax:10090)	Chemical	Gene	Studies|nmod|START_ENTITY Studies|dep|and_amphetamine-regulated_transcript and_amphetamine-regulated_transcript|appos|END_ENTITY	Studies of cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- knockout mice .
16784796	0	cocaine	14,21	CART	61,65	cocaine	CART	MESH:D003042	9607	Chemical	Gene	Processing|nmod|START_ENTITY Processing|dep|proteins proteins|appos|END_ENTITY	Processing of cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- precursor proteins by prohormone convertases -LRB- PCs -RRB- and its implications .
16800814	0	cocaine	106,113	CART	153,157	cocaine	CART	MESH:D003042	9607	Chemical	Gene	START_ENTITY|dep|precursor precursor|appos|END_ENTITY	RNAi-mediated silencing of prohormone_convertase _ -LRB- PC -RRB- _ 5/6 expression leads to impairment in processing of cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- precursor .
17105939	0	cocaine	29,36	CART	23,27	cocaine	CART	MESH:D003042	9607	Chemical	Gene	gene|dep|START_ENTITY gene|amod|END_ENTITY	No association between CART -LRB- cocaine - _ and_amphetamine-regulated_transcript -RRB- gene and methamphetamine dependence .
17196760	0	cocaine	27,34	CART	74,78	cocaine	CART	MESH:D003042	9607	Chemical	Gene	implication|nmod|START_ENTITY implication|dep|and_amphetamine-regulated_transcript and_amphetamine-regulated_transcript|appos|END_ENTITY	Therapeutic implication of cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- in the treatment of depression .
17289142	0	cocaine	63,70	CART	10,14	cocaine	CART	MESH:D003042	29131(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY reduces|dobj|effect reduces|nsubj|55-102 55-102|compound|END_ENTITY	Intra-VTA CART 55-102 reduces the locomotor effect of systemic cocaine in rats : an isobolographic analysis .
17610912	0	cocaine	147,154	CART	18,22	cocaine	CART	MESH:D003042	29131(Tax:10116)	Chemical	Gene	blocks|nmod|START_ENTITY blocks|nsubj|Microinjection Microinjection|nmod|accumbens accumbens|amod|END_ENTITY	Microinjection of CART peptide 55-102 into the nucleus accumbens blocks both the expression of behavioral sensitization and ERK phosphorylation by cocaine .
17616293	0	cocaine	12,19	CART	59,63	cocaine	CART	MESH:D003042	29131(Tax:10116)	Chemical	Gene	Ontogeny|nmod|START_ENTITY Ontogeny|dep|peptide peptide|appos|END_ENTITY	Ontogeny of cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- peptide and calbindin immunoreactivity in granule cells of the dentate gyrus in the rat .
17766010	0	cocaine	41,48	CART	35,39	cocaine	CART	MESH:D003042	29131(Tax:10116)	Chemical	Gene	peptide|dep|START_ENTITY peptide|compound|END_ENTITY	Structure-activity relationship of CART -LRB- cocaine - _ and_amphetamine-regulated_transcript -RRB- peptide fragments .
17900632	0	cocaine	117,124	CART	164,168	cocaine	CART	MESH:D003042	29131(Tax:10116)	Chemical	Gene	systems|nmod|START_ENTITY turnover|nmod|systems stimulation|nmod|turnover effects|nmod|stimulation effects|dep|peptide peptide|appos|END_ENTITY	Gonadal hormones-mediated effects on the stimulation of dopamine turnover in mesolimbic and nigrostriatal systems by cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- peptide in male rats .
18078990	0	cocaine	14,21	CART	61,65	cocaine	CART	MESH:D003042	29131(Tax:10116)	Chemical	Gene	Expression|nmod|START_ENTITY Expression|dep|peptides peptides|appos|END_ENTITY	Expression of cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- peptides at climbing fibre-Purkinje cell synapses in the rat vestibular cerebellum .
18485497	0	cocaine	109,116	CART	13,17	cocaine	CART	MESH:D003042	29131(Tax:10116)	Chemical	Gene	self-administration|compound|START_ENTITY reduces|dobj|self-administration reduces|nsubj|Injection Injection|nmod|END_ENTITY	Injection of CART -LRB- cocaine - _ and_amphetamine-regulated_transcript -RRB- peptide into the nucleus accumbens reduces cocaine self-administration in rats .
18645412	0	cocaine	35,42	CART	82,86	cocaine	CART	MESH:D003042	29131(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY _|nmod|effects _|dobj|peptide peptide|appos|END_ENTITY	In vivo cerebrovascular effects of cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- peptide .
18823957	0	cocaine	27,34	CART	82,86	cocaine	CART	MESH:D003042	29131(Tax:10116)	Chemical	Gene	up-regulation|nmod|START_ENTITY up-regulation|dep|and_amphetamine-regulated_transcript_peptide and_amphetamine-regulated_transcript_peptide|appos|END_ENTITY	Transient up-regulation of cocaine - _ and_amphetamine-regulated_transcript_peptide -LRB- CART -RRB- immunoreactivity following ethanol withdrawal in rat hypothalamus .
18939974	0	cocaine	28,35	CART	22,26	cocaine	CART	MESH:D003042	27220(Tax:10090)	Chemical	Gene	effect|dep|START_ENTITY effect|nmod|END_ENTITY	Synergistic effect of CART -LRB- cocaine - _ and_amphetamine-regulated_transcript -RRB- peptide and cholecystokinin on food intake regulation in lean mice .
19332070	0	cocaine	88,95	CART	135,139	cocaine	CART	MESH:D003042	100286783(Tax:8030)	Chemical	Gene	START_ENTITY|dep|and_amphetamine-regulated_transcript and_amphetamine-regulated_transcript|appos|END_ENTITY	Characterization , tissue distribution , and regulation of agouti-related protein -LRB- AgRP -RRB- , cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- and neuropeptide_Y -LRB- NPY -RRB- in Atlantic_salmon -LRB- Salmo_salar -RRB- .
19490082	0	cocaine	59,66	CART	114,118	cocaine	CART	MESH:D003042	29131(Tax:10116)	Chemical	Gene	Nonselective|nmod|START_ENTITY Nonselective|dep|peptide peptide|appos|END_ENTITY	Nonselective innervation of lamina I projection neurons by cocaine - _ and_amphetamine-regulated_transcript peptide -LRB- CART -RRB- - immunoreactive fibres in the rat spinal dorsal horn .
19523382	0	cocaine	22,29	CART	69,73	cocaine	CART	MESH:D003042	9607	Chemical	Gene	Neuropeptide_Y|appos|START_ENTITY Neuropeptide_Y|dep|and_amphetamine-regulated_transcript and_amphetamine-regulated_transcript|appos|END_ENTITY	Neuropeptide_Y -LRB- NPY -RRB- , cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- and cholecystokinin -LRB- CCK -RRB- in winter skate -LRB- Raja ocellata -RRB- : cDNA cloning , tissue distribution and mRNA expression responses to fasting .
19577595	0	cocaine	17,24	CART	64,68	cocaine	CART	MESH:D003042	29131(Tax:10116)	Chemical	Gene	START_ENTITY|dep|and_amphetamine-regulated_transcript and_amphetamine-regulated_transcript|appos|END_ENTITY	Up-regulation of cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- in the rat nucleus accumbens after repeated electroconvulsive_shock .
20594191	0	cocaine	4,11	CART	51,55	cocaine	CART	MESH:D003042	397252(Tax:9823)	Chemical	Gene	START_ENTITY|dep|and_amphetamine-regulated_transcript and_amphetamine-regulated_transcript|appos|END_ENTITY	The cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- immunoreactivity in the amygdala of the pig .
20626417	0	cocaine	21,28	CART	68,72	cocaine	CART	MESH:D003042	29131(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|and_amphetamine-regulated_transcript and_amphetamine-regulated_transcript|appos|END_ENTITY	Orexigenic effect of cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- after injection into hypothalamic nuclei in streptozotocin-diabetic rats .
20881368	0	cocaine	22,29	CART	16,20	cocaine	CART	MESH:D003042	9607	Chemical	Gene	Distribution|dep|START_ENTITY Distribution|nmod|END_ENTITY	Distribution of CART -LRB- cocaine - _ and_amphetamine-regulated_transcript -RRB- peptide in mature and developing marsupial brain .
21128076	0	cocaine	85,92	CART	132,136	cocaine	CART	MESH:D003042	397252(Tax:9823)	Chemical	Gene	START_ENTITY|dep|genes genes|appos|END_ENTITY	Hypothalamic expression of porcine leptin_receptor -LRB- LEPR -RRB- , neuropeptide_Y -LRB- NPY -RRB- , and cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- genes is influenced by LEPR genotype .
21167239	0	cocaine	34,41	CART	89,93	cocaine	CART	MESH:D003042	29131(Tax:10116)	Chemical	Gene	participation|nmod|START_ENTITY Evidence|nmod|participation Evidence|dep|and_amphetamine-regulated_transcript_peptide and_amphetamine-regulated_transcript_peptide|appos|END_ENTITY	Evidence for the participation of cocaine - _ and_amphetamine-regulated_transcript_peptide -LRB- CART -RRB- in the fluoxetine-induced anti-hyperalgesia in neuropathic rats .
22030409	0	cocaine	28,35	CART	75,79	cocaine	CART	MESH:D003042	9607	Chemical	Gene	transcript|amod|START_ENTITY transcript|appos|END_ENTITY	Comparative distribution of cocaine - and amphetamine-regulated transcript -LRB- CART -RRB- in the hypothalamus of the capuchin monkey -LRB- Cebus_apella -RRB- and the common_marmoset -LRB- Callithrix_jacchus -RRB- .
22252754	0	cocaine	48,55	CART	95,99	cocaine	CART	MESH:D003042	397252(Tax:9823)	Chemical	Gene	pattern|nmod|START_ENTITY pattern|dep|and_amphetamine-regulated_transcript and_amphetamine-regulated_transcript|appos|END_ENTITY	Distribution and chemical coding pattern of the cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- immunoreactivity in the preoptic area of the pig .
22823101	0	cocaine	46,53	CART	93,97	cocaine	CART	MESH:D003042	27220(Tax:10090)	Chemical	Gene	consumption|nmod|START_ENTITY consumption|dep|and_amphetamine-regulated_transcript and_amphetamine-regulated_transcript|appos|END_ENTITY	Reduced ethanol consumption and preference in cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- knockout mice .
23086924	0	cocaine	52,59	CART	99,103	cocaine	CART	MESH:D003042	9607	Chemical	Gene	START_ENTITY|dep|transcription transcription|appos|END_ENTITY	Neuron-restrictive_silencer_factor -LRB- NRSF -RRB- represses cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- transcription and antagonizes cAMP-response element-binding protein signaling through a dual NRSE mechanism .
23206801	0	cocaine	45,52	CART	92,96	cocaine	CART	MESH:D003042	29131(Tax:10116)	Chemical	Gene	hypothalamic|dep|START_ENTITY and_amphetamine-regulated_transcript|amod|hypothalamic and_amphetamine-regulated_transcript|appos|END_ENTITY	Projection patterns of lateral hypothalamic , cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- neurons to the dorsal raphe and/or the locus coeruleus in the rat .
23819981	0	cocaine	91,98	CART	56,60	cocaine	CART	MESH:D003042	9607	Chemical	Gene	administration|compound|START_ENTITY lost|nmod|administration lost|nsubjpass|inhibition inhibition|nmod|activity activity|nmod|END_ENTITY	The inhibition of cocaine-induced locomotor activity by CART 55-102 is lost after repeated cocaine administration .
24161688	0	cocaine	26,33	CART	73,77	cocaine	CART	MESH:D003042	397252(Tax:9823)	Chemical	Gene	patterns|nmod|START_ENTITY patterns|dep|and_amphetamine-regulated_transcript and_amphetamine-regulated_transcript|appos|END_ENTITY	Co-expression patterns of cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- with neuropeptides in dorsal root ganglia of the pig .
24378198	0	cocaine	6,13	CART	122,126	cocaine	CART	MESH:D003042	29131(Tax:10116)	Chemical	Gene	CART|dep|START_ENTITY peptide|nsubj|CART peptide|ccomp|have have|dobj|characteristics characteristics|nmod|receptors receptors|amod|END_ENTITY	CART -LRB- cocaine - _ and_amphetamine-regulated_transcript -RRB- peptide specific binding sites in PC12 cells have characteristics of CART peptide receptors .
24748481	0	cocaine	90,97	CART	137,141	cocaine	CART	MESH:D003042	27220(Tax:10090)	Chemical	Gene	changes|nmod|START_ENTITY treatment|nmod|changes Effect|nmod|treatment Effect|dep|and_amphetamine-regulated_transcript and_amphetamine-regulated_transcript|appos|END_ENTITY	Effect of desipramine and citalopram treatment on forced swimming test-induced changes in cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- immunoreactivity in mice .
24983774	0	cocaine	33,40	CART	80,84	cocaine	CART	MESH:D003042	9607	Chemical	Gene	changes|nmod|START_ENTITY changes|dep|peptide peptide|appos|END_ENTITY	Temperature dependent changes in cocaine - _ and_amphetamine_regulated_transcript -LRB- CART -RRB- peptide in the brain of tadpole , Sylvirana temporalis .
25309361	0	cocaine	94,101	CART	153,157	cocaine	CART	MESH:D003042	9607	Chemical	Gene	response|nmod|START_ENTITY characteristics|nmod|response characteristics|dep|and_amphetamine-regulated_transcript and_amphetamine-regulated_transcript|appos|END_ENTITY	Electrophysiological characteristics of paraventricular thalamic -LRB- PVT -RRB- neurons in response to cocaine and cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- .
25820086	0	cocaine	12,19	CART	59,63	cocaine	CART	MESH:D003042	27220(Tax:10090)	Chemical	Gene	Increase|nmod|START_ENTITY Increase|dep|and_amphetamine-regulated_transcript and_amphetamine-regulated_transcript|appos|END_ENTITY	Increase in cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- in specific areas of the mouse brain by acute caffeine administration .
25820086	2	cocaine	461,468	CART	508,512	cocaine	CART	MESH:D003042	27220(Tax:10090)	Chemical	Gene	START_ENTITY|dep|and_amphetamine-regulated_transcript and_amphetamine-regulated_transcript|appos|END_ENTITY	Although many of the effects of caffeine are mediated by its ability to block adenosine receptors , it is possible that other neural substrates , such as cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- , may be involved in the effects of caffeine .
9268069	0	cocaine	38,45	CART	32,36	cocaine	CART	MESH:D003042	9607	Chemical	Gene	localization|dep|START_ENTITY localization|nmod|END_ENTITY	Ultrastructural localization of CART -LRB- cocaine - _ and_amphetamine-regulated_transcript -RRB- peptides in the nucleus accumbens of monkeys .
9654146	0	cocaine	73,80	CART	119,123	cocaine	CART	MESH:D003042	27220(Tax:10090)	Chemical	Gene	transcript|compound|START_ENTITY transcript|appos|END_ENTITY	Purification and characterisation of a new hypothalamic satiety peptide , cocaine and amphetamine regulated transcript -LRB- CART -RRB- , produced in yeast .
26363222	0	cocaine	49,56	CART1	101,106	cocaine	CART1	MESH:D003042	427871(Tax:9031)	Chemical	Gene	START_ENTITY|dep|gene gene|appos|END_ENTITY	Corticotropin-releasing_hormone -LRB- CRH -RRB- stimulates cocaine - _ and_amphetamine-regulated_transcript gene -LRB- CART1 -RRB- expression through CRH_type_1_receptor -LRB- CRHR1 -RRB- in chicken anterior pituitary .
21755666	0	cocaine	17,24	CARTPT	64,70	cocaine	CARTPT	MESH:D003042	493726(Tax:9913)	Chemical	Gene	transcript|amod|START_ENTITY transcript|appos|END_ENTITY	Putative role of cocaine - and amphetamine-regulated transcript -LRB- CARTPT -RRB- in dominant follicle selection in cattle .
22715379	0	cocaine	73,80	CB1	85,88	cocaine	CB1	MESH:D003042	1268	Chemical	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	A2A adenosine receptor antagonism enhances synaptic and motor effects of cocaine via CB1 cannabinoid receptor activation .
8617431	0	cocaine	119,126	CYP2B10	70,77	cocaine	CYP2B10	MESH:D003042	13088(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Regenerative changes in hepatic morphology and enhanced expression of CYP2B10 and CYP3A during daily administration of cocaine .
26363222	0	cocaine	49,56	Corticotropin-releasing_hormone	0,31	cocaine	Corticotropin-releasing hormone	MESH:D003042	404297(Tax:9031)	Chemical	Gene	stimulates|dobj|START_ENTITY stimulates|nsubj|END_ENTITY	Corticotropin-releasing_hormone -LRB- CRH -RRB- stimulates cocaine - _ and_amphetamine-regulated_transcript gene -LRB- CART1 -RRB- expression through CRH_type_1_receptor -LRB- CRHR1 -RRB- in chicken anterior pituitary .
21917801	0	cocaine	6,13	D1_receptor	41,52	cocaine	D1 receptor	MESH:D003042	13488(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|nmod|END_ENTITY	Acute cocaine induces fast activation of D1_receptor and progressive deactivation of D2_receptor striatal neurons : in vivo optical microprobe -LSB- Ca2 + -RSB- i imaging .
10581411	0	cocaine	56,63	Dopamine_transporter	0,20	cocaine	Dopamine transporter	MESH:D003042	6531	Chemical	Gene	users|compound|START_ENTITY mRNA|nmod|users mRNA|compound|END_ENTITY	Dopamine_transporter mRNA in autopsy studies of chronic cocaine users .
11901228	0	cocaine	100,107	Dopamine_transporter	0,20	cocaine	Dopamine transporter	MESH:D003042	6531	Chemical	Gene	antagonism|compound|START_ENTITY targets|nmod|antagonism provide|dobj|targets provide|nsubj|mutants mutants|amod|END_ENTITY	Dopamine_transporter mutants with cocaine resistance and normal dopamine uptake provide targets for cocaine antagonism .
11901228	0	cocaine	34,41	Dopamine_transporter	0,20	cocaine	Dopamine transporter	MESH:D003042	6531	Chemical	Gene	resistance|compound|START_ENTITY mutants|nmod|resistance mutants|amod|END_ENTITY	Dopamine_transporter mutants with cocaine resistance and normal dopamine uptake provide targets for cocaine antagonism .
1482766	0	cocaine	51,58	Dopamine_transporter	0,20	cocaine	Dopamine transporter	MESH:D003042	6531	Chemical	Gene	analogs|compound|START_ENTITY END_ENTITY|nmod|analogs	Dopamine_transporter imaging with novel , selective cocaine analogs .
18565692	0	cocaine	31,38	Dopamine_transporter	0,20	cocaine	Dopamine transporter	MESH:D003042	6531	Chemical	Gene	subjects|compound|START_ENTITY levels|nmod|subjects levels|amod|END_ENTITY	Dopamine_transporter levels in cocaine dependent subjects .
20015297	0	cocaine	56,63	Dopamine_transporter	0,20	cocaine	Dopamine transporter	MESH:D003042	13162(Tax:10090)	Chemical	Gene	down-regulation|nmod|START_ENTITY down-regulation|amod|END_ENTITY	Dopamine_transporter down-regulation following repeated cocaine : implications for 3,4-methylenedioxymethamphetamine-induced acute effects and long-term neurotoxicity in mice .
25580950	0	cocaine	86,93	Dopamine_transporter	0,20	cocaine	Dopamine transporter	MESH:D003042	6531	Chemical	Gene	affinities|compound|START_ENTITY combining|nmod|affinities impact|acl|combining oligomerization|dep|impact oligomerization|amod|END_ENTITY	Dopamine_transporter oligomerization : impact of combining protomers with differential cocaine analog binding affinities .
10632609	0	cocaine	80,87	Fos	0,3	cocaine	Fos	MESH:D003042	314322(Tax:10116)	Chemical	Gene	environment|compound|START_ENTITY END_ENTITY|nmod|environment	Fos protein expression and cocaine-seeking behavior in rats after exposure to a cocaine self-administration environment .
21962331	0	cocaine	41,48	FosB	2,6	cocaine	FosB	MESH:D003042	14282(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY enhances|dobj|effects enhances|nsubj|END_ENTITY	/ \ FosB enhances the rewarding effects of cocaine while reducing the pro-depressive effects of the kappa-opioid receptor agonist U50488 .
22649236	0	cocaine	86,93	FosB	109,113	cocaine	FosB	MESH:D003042	14282(Tax:10090)	Chemical	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	Serum_response_factor and cAMP_response_element_binding_protein are both required for cocaine induction of / \ FosB .
24505362	0	cocaine	43,50	GSK3	4,8	cocaine	GSK3	MESH:D003042	56637(Tax:10090)	Chemical	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	The GSK3 signaling pathway is activated by cocaine and is critical for cocaine conditioned reward in mice .
18823173	0	cocaine	93,100	Insulin_receptor_substrate-2	0,28	cocaine	Insulin receptor substrate-2	MESH:D003042	8660	Chemical	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Insulin_receptor_substrate-2 in the ventral tegmental area regulates behavioral responses to cocaine .
20653129	0	cocaine	12,19	LDH_and_SDH	45,56	cocaine	LDH and SDH	MESH:D003042	231691(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activities activities|nmod|END_ENTITY	-LSB- Effects of cocaine on activities of ATPase , LDH_and_SDH in mouse splenocytes -RSB- .
24936739	0	cocaine	83,90	MeCP2	27,32	cocaine	MeCP2	MESH:D003042	29386(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of MeCP2 and PP1 in passive or voluntary administration of cocaine or food .
16574078	0	cocaine	80,87	Neurotensin	0,11	cocaine	Neurotensin	MESH:D003042	299757(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY sensitizes|nmod|effect sensitizes|amod|END_ENTITY	Neurotensin receptor activation sensitizes to the locomotor stimulant effect of cocaine : a role for NMDA receptors .
17356568	0	cocaine	52,59	Neurotensin	0,11	cocaine	Neurotensin	MESH:D003042	299757(Tax:10116)	Chemical	Gene	withdrawal_decreases_locomotor_sensitization|compound|START_ENTITY administered|nmod|withdrawal_decreases_locomotor_sensitization administered|nsubj|antagonist antagonist|compound|END_ENTITY	Neurotensin receptor antagonist administered during cocaine withdrawal_decreases_locomotor_sensitization and conditioned place preference .
25379267	0	cocaine	56,63	Neurotensin	0,11	cocaine	Neurotensin	MESH:D003042	299757(Tax:10116)	Chemical	Gene	sensitization|compound|START_ENTITY attenuates|nmod|sensitization attenuates|nsubj|agonist agonist|compound|END_ENTITY	Neurotensin agonist attenuates nicotine potentiation to cocaine sensitization .
8242350	0	cocaine	86,93	Neurotensin	0,11	cocaine	Neurotensin	MESH:D003042	299757(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY blocks|dobj|effects blocks|nsubj|END_ENTITY	Neurotensin injected into the nucleus accumbens blocks the psychostimulant effects of cocaine but does not attenuate cocaine self-administration in the rat .
15763139	0	cocaine	69,76	Norepinephrine_transporter	0,26	cocaine	Norepinephrine transporter	MESH:D003042	6530	Chemical	Gene	abusers|compound|START_ENTITY immunoblotting|nmod|abusers END_ENTITY|dobj|immunoblotting	Norepinephrine_transporter immunoblotting and radioligand binding in cocaine abusers .
9030708	0	cocaine	86,93	Prodynorphin	0,12	cocaine	Prodynorphin	MESH:D003042	29190(Tax:10116)	Chemical	Gene	opioid|nmod|START_ENTITY opioid|nsubj|END_ENTITY	Prodynorphin , proenkephalin and kappa opioid receptor mRNA responses to acute `` binge '' cocaine .
17632279	0	cocaine	8,15	RGS4	24,28	cocaine	RGS4	MESH:D003042	29480(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|mRNA mRNA|compound|END_ENTITY	Chronic cocaine reduces RGS4 mRNA in rat prefrontal cortex and dorsal striatum .
8041492	0	cocaine	9,16	S-100_beta	46,56	cocaine	S-100 beta	MESH:D003042	6285	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|END_ENTITY	Prenatal cocaine decreases the trophic factor S-100_beta and induced microcephaly : reversal by postnatal 5-HT1A_receptor agonist .
25774451	0	cocaine	44,51	Tet1	8,12	cocaine	Tet1	MESH:D003042	52463(Tax:10090)	Chemical	Gene	action|compound|START_ENTITY Role|nmod|action Role|nmod|END_ENTITY	Role of Tet1 and 5-hydroxymethylcytosine in cocaine action .
1319008	0	cocaine	11,18	alpha-melanocyte-stimulating_hormone	52,88	cocaine	alpha-melanocyte-stimulating hormone	MESH:D003042	24664(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|compound|END_ENTITY	Effects of cocaine and pimozide on plasma and brain alpha-melanocyte-stimulating_hormone levels in rats .
15680464	0	cocaine	87,94	angiotensin_II	8,22	cocaine	angiotensin II	MESH:D003042	24179(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of angiotensin_II and corticotropin-releasing_hormone in hemodynamic responses to cocaine and stress .
12603818	0	cocaine	55,62	beta-endorphin	80,94	cocaine	beta-endorphin	MESH:D003042	5443	Chemical	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	Effect of experimenter-delivered and self-administered cocaine on extracellular beta-endorphin levels in the nucleus accumbens .
10027503	0	cocaine	28,35	c-fos	72,77	cocaine	c-fos	MESH:D003042	14281(Tax:10090)	Chemical	Gene	sensitization|nmod|START_ENTITY sensitization|dep|expression expression|amod|END_ENTITY	Behavioral sensitization to cocaine after a brief social defeat stress : c-fos expression in the PAG .
10521585	0	cocaine	233,240	c-fos	165,170	cocaine	c-fos	MESH:D003042	314322(Tax:10116)	Chemical	Gene	drugs|dep|START_ENTITY causes|nmod|drugs causes|dobj|expression expression|amod|END_ENTITY	Acute injection of drugs with low addictive potential -LRB- delta -LRB- 9 -RRB- - tetrahydrocannabinol , 3,4-methylenedioxymethamphetamine , lysergic_acid_diamide -RRB- causes a much higher c-fos expression in limbic brain areas than highly addicting drugs -LRB- cocaine and morphine -RRB- .
10564376	0	cocaine	92,99	c-fos	14,19	cocaine	c-fos	MESH:D003042	14281(Tax:10090)	Chemical	Gene	self-administration|compound|START_ENTITY initiation|nmod|self-administration mRNA|nmod|initiation mRNA|nsubj|Expression Expression|nmod|END_ENTITY	Expression of c-fos , NGFI-A and secretogranin_II mRNA in brain regions during initiation of cocaine self-administration in mice .
11716816	0	cocaine	47,54	c-fos	81,86	cocaine	c-fos	MESH:D003042	314322(Tax:10116)	Chemical	Gene	ability|nmod|START_ENTITY modulates|dobj|ability modulates|xcomp|induce induce|dobj|expression expression|amod|END_ENTITY	Environmental context modulates the ability of cocaine and amphetamine to induce c-fos mRNA expression in the neocortex , caudate nucleus , and nucleus accumbens .
12128156	0	cocaine	11,18	c-fos	22,27	cocaine	c-fos	MESH:D003042	314322(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|amod|END_ENTITY	Effects of cocaine on c-fos and preprodynorphin mRNA levels in intact and ovariectomized Fischer rats .
14559159	0	cocaine	18,25	c-fos	39,44	cocaine	c-fos	MESH:D003042	314322(Tax:10116)	Chemical	Gene	induction|compound|START_ENTITY induction|nmod|levels levels|amod|END_ENTITY	MK-801 attenuates cocaine induction of c-fos and preprodynorphin mRNA levels in Fischer rats .
1498673	0	cocaine	46,53	c-fos	14,19	cocaine	c-fos	MESH:D003042	314322(Tax:10116)	Chemical	Gene	seizures|compound|START_ENTITY Expression|nmod|seizures Expression|nmod|mRNA mRNA|amod|END_ENTITY	Expression of c-fos mRNA in acute and kindled cocaine seizures in rats .
15955413	0	cocaine	147,154	c-fos	56,61	cocaine	c-fos	MESH:D003042	314322(Tax:10116)	Chemical	Gene	pre-exposure|compound|START_ENTITY effects|nmod|pre-exposure parallels|dobj|effects effect|acl:relcl|parallels expression|dep|effect expression|nmod|mRNA mRNA|amod|END_ENTITY	Cocaine pre-exposure enhances CRF-induced expression of c-fos mRNA in the central nucleus of the amygdala : an effect that parallels the effects of cocaine pre-exposure on CRF-induced locomotor activity .
18396266	0	cocaine	24,31	c-fos	54,59	cocaine	c-fos	MESH:D003042	314322(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY rate|nmod|administration alters|nsubj|rate alters|dobj|expression expression|amod|END_ENTITY	The rate of intravenous cocaine administration alters c-fos mRNA expression and the temporal dynamics of dopamine , but not glutamate , overflow in the striatum .
7534774	0	cocaine	64,71	c-fos	45,50	cocaine	c-fos	MESH:D003042	314322(Tax:10116)	Chemical	Gene	defines|nmod|START_ENTITY defines|dobj|specificity specificity|nmod|induction induction|amod|END_ENTITY	Substance P phenotype defines specificity of c-fos induction by cocaine in developing rat striatum .
8069690	0	cocaine	41,48	c-fos	13,18	cocaine	c-fos	MESH:D003042	314322(Tax:10116)	Chemical	Gene	brain|nmod|START_ENTITY END_ENTITY|nmod|brain	Induction of c-fos in rat brain by acute cocaine and fenfluramine exposure : a comparison study .
8426221	0	cocaine	75,82	c-fos	25,30	cocaine	c-fos	MESH:D003042	314322(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|expression expression|nmod|END_ENTITY	Coordinate expression of c-fos and jun_B is induced in the rat striatum by cocaine .
9145913	0	cocaine	55,62	c-fos	66,71	cocaine	c-fos	MESH:D003042	14281(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY modulate|dobj|effect modulate|nmod|expression expression|amod|END_ENTITY	5-Hydroxytryptamine1B receptors modulate the effect of cocaine on c-fos expression : converging evidence using 5-hydroxytryptamine1B knockout mice and the 5-hydroxytryptamine1B / 1D antagonist GR127935 .
23876860	0	cocaine	76,83	calsequestrin	26,39	cocaine	calsequestrin	MESH:D003042	844	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Potential role of cardiac calsequestrin in the lethal arrhythmic effects of cocaine .
1500830	0	cocaine	93,100	cholinesterase	36,50	cocaine	cholinesterase	MESH:D003042	100624138	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activity activity|amod|END_ENTITY	The effects of inhibition of plasma cholinesterase and hepatic microsomal enzyme activity on cocaine , benzoylecgonine , ecgonine_methyl_ester , and norcocaine blood levels in pigs .
7964130	0	cocaine	66,73	cholinesterase	37,51	cocaine	cholinesterase	MESH:D003042	100624138	Chemical	Gene	metabolism|compound|START_ENTITY inhibition|nmod|metabolism END_ENTITY|dobj|inhibition	The effect of hepatectomy and plasma cholinesterase inhibition on cocaine metabolism and cardiovascular responses in pigs .
8340704	0	cocaine	117,124	cholinesterase	36,50	cocaine	cholinesterase	MESH:D003042	100624138	Chemical	Gene	infusion|compound|START_ENTITY END_ENTITY|nmod|infusion	The effects of inhibition of plasma cholinesterase activity on systemic toxicity and blood catecholamine levels from cocaine infusion in pigs .
16822557	0	cocaine	101,108	corticotropin-releasing_factor	11,41	cocaine	corticotropin-releasing factor	MESH:D003042	1392	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A role for corticotropin-releasing_factor in the long-term expression of behavioral sensitization to cocaine .
15519677	0	cocaine	93,100	corticotropin-releasing_hormone	104,135	cocaine	corticotropin-releasing hormone	MESH:D003042	81648(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	Effects of selective D1 - or D2-like dopamine receptor antagonists with acute `` binge '' pattern cocaine on corticotropin-releasing_hormone and proopiomelanocortin mRNA levels in the hypothalamus .
14751291	0	cocaine	19,26	corticotropin-releasing_hormone_binding_protein	39,86	cocaine	corticotropin-releasing hormone binding protein	MESH:D003042	29625(Tax:10116)	Chemical	Gene	exposure|compound|START_ENTITY exposure|nmod|END_ENTITY	Effects of chronic cocaine exposure on corticotropin-releasing_hormone_binding_protein in the central nucleus of the amygdala and bed nucleus of the stria terminalis .
11222986	0	cocaine	103,110	corticotropin_releasing_factor	8,38	cocaine	corticotropin releasing factor	MESH:D003042	81648(Tax:10116)	Chemical	Gene	mediate|nmod|START_ENTITY mediate|nsubj|END_ENTITY	Central corticotropin_releasing_factor -LRB- CRF -RRB- and adrenergic receptors mediate hemodynamic responses to cocaine .
10082805	0	cocaine	11,18	dopamine_transporter	152,172	cocaine	dopamine transporter	MESH:D003042	13162(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY locomotor|nsubj|Effects locomotor|parataxis|involves involves|dobj|upregulation upregulation|nmod|sites sites|compound|END_ENTITY	Effects of cocaine , nicotine , dizocipline and alcohol on mice locomotor activity : cocaine-alcohol cross-sensitization involves upregulation of striatal dopamine_transporter binding sites .
10420170	0	cocaine	140,147	dopamine_transporter	74,94	cocaine	dopamine transporter	MESH:D003042	6531	Chemical	Gene	expressed|nmod|START_ENTITY expressed|nsubj|mechanism mechanism|nmod|transport transport|nmod|dopamine dopamine|nmod|END_ENTITY	Multisubtrate mechanism for the inward transport of dopamine by the human dopamine_transporter expressed in HEK cells and its inhibition by cocaine .
10537056	0	cocaine	67,74	dopamine_transporter	18,38	cocaine	dopamine transporter	MESH:D003042	24898(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY END_ENTITY|nmod|administration	Regulation of rat dopamine_transporter mRNA and protein by chronic cocaine administration .
10592290	0	cocaine	57,64	dopamine_transporter	81,101	cocaine	dopamine transporter	MESH:D003042	6531	Chemical	Gene	effects|nmod|START_ENTITY enhances|dobj|effects enhances|nmod|END_ENTITY	Isoflurane anesthesia enhances the inhibitory effects of cocaine and GBR12909 on dopamine_transporter : PET studies in combination with microdialysis in the monkey brain .
10669562	0	cocaine	141,148	dopamine_transporter	21,41	cocaine	dopamine transporter	MESH:D003042	24898(Tax:10116)	Chemical	Gene	antagonist|compound|START_ENTITY piperidyl_4-methylphenyl_ketone|nmod|antagonist -3|amod|piperidyl_4-methylphenyl_ketone 4-methylphenyl|dep|-3 Discovery|dep|4-methylphenyl Discovery|nmod|inhibitor inhibitor|compound|END_ENTITY	Discovery of a novel dopamine_transporter inhibitor , 4-hydroxy-1-methyl-4 - -LRB- 4-methylphenyl -RRB- -3 - piperidyl_4-methylphenyl_ketone , as a potential cocaine antagonist through 3D-database pharmacophore searching .
10924700	0	cocaine	194,201	dopamine_transporter	77,97	cocaine	dopamine transporter	MESH:D003042	6531	Chemical	Gene	configuration|nmod|START_ENTITY mimicking|dobj|configuration inhibited|xcomp|mimicking inhibited|nsubj|uptake uptake|nmod|cells cells|acl|expressing expressing|dobj|END_ENTITY	Dopamine uptake by mouse neuroblastoma N1E-115 cells stably expressing human dopamine_transporter is differentially inhibited by anti-idiotypic ab2beta antibodies mimicking the configuration of cocaine .
10983846	0	cocaine	38,45	dopamine_transporter	54,74	cocaine	dopamine transporter	MESH:D003042	6531	Chemical	Gene	Effects|nmod|START_ENTITY Effects|acl|induced induced|dobj|blockade blockade|compound|END_ENTITY	Effects of route of administration on cocaine induced dopamine_transporter blockade in the human brain .
11020233	0	cocaine	82,89	dopamine_transporter	106,126	cocaine	dopamine transporter	MESH:D003042	24898(Tax:10116)	Chemical	Gene	antagonists|compound|START_ENTITY putative|dobj|antagonists putative|nmod|activity activity|compound|END_ENTITY	Novel in vivo electrophysiological assay for the effects of cocaine and putative `` cocaine antagonists '' on dopamine_transporter activity of substantia nigra and ventral tegmental area dopamine neurons .
11306632	0	cocaine	83,90	dopamine_transporter	26,46	cocaine	dopamine transporter	MESH:D003042	574143(Tax:9544)	Chemical	Gene	self-administration|compound|START_ENTITY result|nmod|self-administration binding|nmod|result binding|nsubj|Progression Progression|nmod|changes changes|nmod|END_ENTITY	Progression of changes in dopamine_transporter binding site density as a result of cocaine self-administration in rhesus_monkeys .
11395483	0	cocaine	22,29	dopamine_transporter	97,117	cocaine	dopamine transporter	MESH:D003042	6531	Chemical	Gene	alter|nsubj|START_ENTITY alter|dobj|conformation conformation|nmod|END_ENTITY	The uptake inhibitors cocaine and benztropine differentially alter the conformation of the human dopamine_transporter .
11746736	0	cocaine	23,30	dopamine_transporter	79,99	cocaine	dopamine transporter	MESH:D003042	574143(Tax:9544)	Chemical	Gene	Self-administration|nmod|START_ENTITY Self-administration|dep|relationship relationship|nmod|occupancy occupancy|compound|END_ENTITY	Self-administration of cocaine and the cocaine analog RTI-113 : relationship to dopamine_transporter occupancy determined by PET neuroimaging in rhesus_monkeys .
11984856	0	cocaine	73,80	dopamine_transporter	15,35	cocaine	dopamine transporter	MESH:D003042	6531	Chemical	Gene	injections|nmod|START_ENTITY occupancy|nmod|injections occupancy|compound|END_ENTITY	Measurement of dopamine_transporter occupancy for multiple injections of cocaine using a single injection of -LSB- F-18 -RSB- FECNT .
11989984	0	cocaine	51,58	dopamine_transporter	26,46	cocaine	dopamine transporter	MESH:D003042	6531	Chemical	Gene	analog|compound|START_ENTITY END_ENTITY|nmod|analog	The functional domains of dopamine_transporter for cocaine analog , CFT binding .
12006604	0	cocaine	8,15	dopamine_transporter	95,115	cocaine	dopamine transporter	MESH:D003042	13162(Tax:10090)	Chemical	Gene	effect|compound|START_ENTITY Lack|nmod|effect accumbens|nsubj|Lack accumbens|nmod|mice mice|amod|END_ENTITY	Lack of cocaine effect on dopamine clearance in the core and shell of the nucleus accumbens of dopamine_transporter knock-out mice .
12068085	0	cocaine	133,140	dopamine_transporter	35,55	cocaine	dopamine transporter	MESH:D003042	6531	Chemical	Gene	analog|compound|START_ENTITY those|nmod|analog reveal|nmod|those reveal|nsubj|interactions interactions|nmod|END_ENTITY	Cationic interactions at the human dopamine_transporter reveal binding conformations for dopamine distinguishable from those for the cocaine analog 2 alpha-carbomethoxy-3_alpha - -LRB- 4-fluorophenyl -RRB- tropane .
12213053	0	cocaine	50,57	dopamine_transporter	78,98	cocaine	dopamine transporter	MESH:D003042	24898(Tax:10116)	Chemical	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Mazindol analogues as potential inhibitors of the cocaine binding site at the dopamine_transporter .
12213054	0	cocaine	72,79	dopamine_transporter	100,120	cocaine	dopamine transporter	MESH:D003042	6531	Chemical	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Benzo - _ and_cyclohexanomazindol analogues as potential inhibitors of the cocaine binding site at the dopamine_transporter .
12394414	0	cocaine	10,17	dopamine_transporter	125,145	cocaine	dopamine transporter	MESH:D003042	24898(Tax:10116)	Chemical	Gene	period|compound|START_ENTITY Effect|nmod|period Effect|nmod|END_ENTITY	Effect of cocaine and sucrose withdrawal period on extinction behavior , cue-induced reinstatement , and protein levels of the dopamine_transporter and tyrosine_hydroxylase in limbic and cortical areas in rats .
12490570	0	cocaine	25,32	dopamine_transporter	40,60	cocaine	dopamine transporter	MESH:D003042	24898(Tax:10116)	Chemical	Gene	Withdrawal|nmod|START_ENTITY alters|nsubj|Withdrawal alters|dobj|turnover turnover|compound|END_ENTITY	Withdrawal from repeated cocaine alters dopamine_transporter protein turnover in the rat striatum .
12869648	0	cocaine	30,37	dopamine_transporter	91,111	cocaine	dopamine transporter	MESH:D003042	24898(Tax:10116)	Chemical	Gene	analog|compound|START_ENTITY Dissociation|nmod|analog uptake|nsubj|Dissociation uptake|nmod|END_ENTITY	Dissociation of high-affinity cocaine analog binding and dopamine uptake inhibition at the dopamine_transporter .
12878327	0	cocaine	14,21	dopamine_transporter	43,63	cocaine	dopamine transporter	MESH:D003042	6531	Chemical	Gene	START_ENTITY|amod|binding binding|nmod|END_ENTITY	Inhibition of cocaine binding to the human dopamine_transporter by a single chain anti-idiotypic antibody : its cloning , expression , and functional properties .
14519759	0	cocaine	152,159	dopamine_transporter	10,30	cocaine	dopamine transporter	MESH:D003042	6531	Chemical	Gene	analogs|compound|START_ENTITY sensitive|nmod|analogs forms|parataxis|sensitive forms|nsubj|END_ENTITY	The human dopamine_transporter forms a tetramer in the plasma membrane : cross-linking of a cysteine in the fourth transmembrane segment is sensitive to cocaine analogs .
14691264	0	cocaine	21,28	dopamine_transporter	58,78	cocaine	dopamine transporter	MESH:D003042	13162(Tax:10090)	Chemical	Gene	effects|compound|START_ENTITY effects|nmod|mice mice|nmod|END_ENTITY	Role of serotonin in cocaine effects in mice with reduced dopamine_transporter function .
1482769	0	cocaine	45,52	dopamine_transporter	10,30	cocaine	dopamine transporter	MESH:D003042	6531	Chemical	Gene	analogs|compound|START_ENTITY Selective|nmod|analogs Selective|dobj|inhibition inhibition|compound|END_ENTITY	Selective dopamine_transporter inhibition by cocaine analogs .
1494906	0	cocaine	58,65	dopamine_transporter	20,40	cocaine	dopamine transporter	MESH:D003042	6531	Chemical	Gene	treatment|compound|START_ENTITY effects|nmod|treatment Quantitation|dep|effects Quantitation|nmod|mRNA mRNA|compound|END_ENTITY	Quantitation of rat dopamine_transporter mRNA : effects of cocaine treatment and withdrawal .
14982963	0	cocaine	46,53	dopamine_transporter	11,31	cocaine	dopamine transporter	MESH:D003042	574143(Tax:9544)	Chemical	Gene	self-administration|compound|START_ENTITY inhibitors|nmod|self-administration inhibitors|compound|END_ENTITY	Effects of dopamine_transporter inhibitors on cocaine self-administration in rhesus_monkeys : relationship to transporter occupancy determined by positron emission tomography neuroimaging .
15140185	0	cocaine	144,151	dopamine_transporter	36,56	cocaine	dopamine transporter	MESH:D003042	6531	Chemical	Gene	opposed|nmod|START_ENTITY reveals|xcomp|opposed reveals|nsubj|Mutation Mutation|nmod|Trp84 Trp84|nmod|END_ENTITY	Mutation of Trp84 and Asp313 of the dopamine_transporter reveals similar mode of binding interaction for GBR12909 and benztropine as opposed to cocaine .
15292903	0	cocaine	26,33	dopamine_transporter	119,139	cocaine	dopamine transporter	MESH:D003042	24898(Tax:10116)	Chemical	Gene	differences|nmod|START_ENTITY differences|dep|contribution contribution|nmod|END_ENTITY	Individual differences in cocaine - and amphetamine-induced activation of male Sprague-Dawley_rats : contribution of the dopamine_transporter .
15566285	0	cocaine	39,46	dopamine_transporter	54,74	cocaine	dopamine transporter	MESH:D003042	6531	Chemical	Gene	analogues|nmod|START_ENTITY study|nmod|analogues study|nmod|END_ENTITY	CoMFA study of piperidine analogues of cocaine at the dopamine_transporter : exploring the binding mode of the 3 alpha-substituent of the piperidine ring using pharmacophore-based flexible alignment .
15719221	0	cocaine	52,59	dopamine_transporter	72,92	cocaine	dopamine transporter	MESH:D003042	13162(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|compound|END_ENTITY	Characterization of conditioned place preference to cocaine in congenic dopamine_transporter knockout female mice .
15728828	0	cocaine	85,92	dopamine_transporter	20,40	cocaine	dopamine transporter	MESH:D003042	6531	Chemical	Gene	effects|nmod|START_ENTITY blocks|dobj|effects ligand|ccomp|blocks ligand|nsubj|Identification Identification|nmod|END_ENTITY	Identification of a dopamine_transporter ligand that blocks the stimulant effects of cocaine .
15879005	0	cocaine	123,130	dopamine_transporter	34,54	cocaine	dopamine transporter	MESH:D003042	6531	Chemical	Gene	inhibitors|dobj|START_ENTITY inhibitors|dep|differs differs|nsubj|Recognition Recognition|nmod|benztropine benztropine|nmod|END_ENTITY	Recognition of benztropine by the dopamine_transporter -LRB- DAT -RRB- differs from that of the classical dopamine uptake inhibitors cocaine , methylphenidate , and mazindol as a function of a DAT transmembrane 1 aspartic_acid residue .
15998286	0	cocaine	117,124	dopamine_transporter	62,82	cocaine	dopamine transporter	MESH:D003042	13162(Tax:10090)	Chemical	Gene	decreases|nmod|START_ENTITY decreases|nsubj|mutation mutation|nmod|domain domain|nmod|markedly markedly|compound|END_ENTITY	A triple mutation in the second transmembrane domain of mouse dopamine_transporter markedly decreases sensitivity to cocaine and methylphenidate .
16009468	0	cocaine	129,136	dopamine_transporter	79,99	cocaine	dopamine transporter	MESH:D003042	6531	Chemical	Gene	inhibitor|compound|START_ENTITY going|nmod|inhibitor the|acl|going END_ENTITY|nmod|the	Structure-activity relationship of trihexyphenidyl analogs with respect to the dopamine_transporter in the on going search for a cocaine inhibitor .
16216288	0	cocaine	108,115	dopamine_transporter	48,68	cocaine	dopamine transporter	MESH:D003042	6531	Chemical	Gene	effects|nmod|START_ENTITY responsible|nmod|effects responsible|nsubj|configuration configuration|nmod|TM2 TM2|nmod|END_ENTITY	A pincer-like configuration of TM2 in the human dopamine_transporter is responsible for indirect effects on cocaine binding .
16712814	0	cocaine	66,73	dopamine_transporter	108,128	cocaine	dopamine transporter	MESH:D003042	6531	Chemical	Gene	access|nmod|START_ENTITY hour|nmod|access results|nsubj|hour results|nmod|levels levels|nmod|END_ENTITY	One hour , but not six hours , of daily access to self-administered cocaine results in elevated levels of the dopamine_transporter .
16754872	0	cocaine	10,17	dopamine_transporter	60,80	cocaine	dopamine transporter	MESH:D003042	13162(Tax:10090)	Chemical	Gene	reward|compound|START_ENTITY reward|nmod|END_ENTITY	Abolished cocaine reward in mice with a cocaine-insensitive dopamine_transporter .
17169338	0	cocaine	57,64	dopamine_transporter	121,141	cocaine	dopamine transporter	MESH:D003042	6531	Chemical	Gene	inhibition|nmod|START_ENTITY uptake|xcomp|inhibition uptake|nmod|cells cells|acl|expressing expressing|dobj|END_ENTITY	Fluctuation of the dopamine uptake inhibition potency of cocaine , but not amphetamine , at mammalian cells expressing the dopamine_transporter .
17255098	0	cocaine	16,23	dopamine_transporter	98,118	cocaine	dopamine transporter	MESH:D003042	6531	Chemical	Gene	RTI_82|compound|START_ENTITY Localization|nmod|RTI_82 irreversible|nsubj|Localization irreversible|xcomp|binding binding|xcomp|transmembrane transmembrane|dobj|domain domain|nmod|END_ENTITY	Localization of cocaine analog -LSB- 125I -RSB- RTI_82 irreversible binding to transmembrane domain 6 of the dopamine_transporter .
1796351	0	cocaine	20,27	dopamine_transporter	66,86	cocaine	dopamine transporter	MESH:D003042	6531	Chemical	Gene	sites|compound|START_ENTITY depletion|nmod|sites associated|nsubj|depletion associated|nmod|END_ENTITY	Severe depletion of cocaine recognition sites associated with the dopamine_transporter in Parkinson 's - diseased striatum .
18198344	0	cocaine	85,92	dopamine_transporter	17,37	cocaine	dopamine transporter	MESH:D003042	24898(Tax:10116)	Chemical	Gene	self-administration|compound|START_ENTITY abstinence|nmod|self-administration Dysregulation|nmod|abstinence Dysregulation|nmod|trafficking trafficking|compound|END_ENTITY	Dysregulation of dopamine_transporter trafficking and function after abstinence from cocaine self-administration in rats : evidence for differential regulation in caudate putamen and nucleus accumbens .
18216182	0	cocaine	193,200	dopamine_transporter	12,32	cocaine	dopamine transporter	MESH:D003042	24898(Tax:10116)	Chemical	Gene	sites|compound|START_ENTITY implicates|nmod|sites Labeling|dep|implicates Labeling|nmod|domain domain|compound|END_ENTITY	Labeling of dopamine_transporter transmembrane domain 1 with the tropane ligand N - -LSB- 4 - -LRB- 4-azido-3 - -LSB- 125I -RSB- iodophenyl -RRB- butyl -RSB- -2 beta-carbomethoxy-3beta - -LRB- 4-chlorophenyl -RRB- tropane implicates proximity of cocaine and substrate active sites .
18286542	0	cocaine	15,22	dopamine_transporter	77,97	cocaine	dopamine transporter	MESH:D003042	13162(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY attenuated|nsubjpass|effects attenuated|nmod|mice mice|compound|END_ENTITY	The effects of cocaine on regional brain glucose metabolism is attenuated in dopamine_transporter knockout mice .
18568020	0	cocaine	22,29	dopamine_transporter	50,70	cocaine	dopamine transporter	MESH:D003042	6531	Chemical	Gene	sites|nmod|START_ENTITY sites|nmod|END_ENTITY	The binding sites for cocaine and dopamine in the dopamine_transporter overlap .
19474307	0	cocaine	88,95	dopamine_transporter	17,37	cocaine	dopamine transporter	MESH:D003042	6531	Chemical	Gene	analogs|compound|START_ENTITY Visualization|nmod|analogs Visualization|nmod|trafficking trafficking|compound|END_ENTITY	Visualization of dopamine_transporter trafficking in live neurons by use of fluorescent cocaine analogs .
19602552	0	cocaine	8,15	dopamine_transporter	77,97	cocaine	dopamine transporter	MESH:D003042	13162(Tax:10090)	Chemical	Gene	self-administration|compound|START_ENTITY Lack|nmod|self-administration Lack|acl|expressing expressing|dobj|END_ENTITY	Lack of cocaine self-administration in mice expressing a cocaine-insensitive dopamine_transporter .
1988563	0	cocaine	23,30	dopamine_transporter	73,93	cocaine	dopamine transporter	MESH:D003042	6531	Chemical	Gene	metabolite|compound|START_ENTITY displays|nsubj|metabolite displays|dobj|affinity affinity|nmod|END_ENTITY	Cocaethylene : a unique cocaine metabolite displays high affinity for the dopamine_transporter .
20035724	0	cocaine	76,83	dopamine_transporter	8,28	cocaine	dopamine transporter	MESH:D003042	24898(Tax:10116)	Chemical	Gene	self-administration|compound|START_ENTITY function|nmod|self-administration END_ENTITY|dobj|function	Altered dopamine_transporter function and phosphorylation following chronic cocaine self-administration and extinction in rats .
21185387	0	cocaine	78,85	dopamine_transporter	89,109	cocaine	dopamine transporter	MESH:D003042	13162(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|compound|END_ENTITY	Quantitative pharmacologic MRI : mapping the cerebral blood volume response to cocaine in dopamine_transporter knockout mice .
21859929	0	cocaine	13,20	dopamine_transporter	69,89	cocaine	dopamine transporter	MESH:D003042	6531	Chemical	Gene	self-administration|compound|START_ENTITY Decreases|nmod|self-administration Decreases|nmod|END_ENTITY	Decreases in cocaine self-administration with dual inhibition of the dopamine_transporter and receptors .
23079638	0	cocaine	54,61	dopamine_transporter	69,89	cocaine	dopamine transporter	MESH:D003042	6531	Chemical	Gene	site|nmod|START_ENTITY site|nmod|pathways pathways|compound|END_ENTITY	Insights from molecular dynamics : the binding site of cocaine in the dopamine_transporter and permeation pathways of substrates in the leucine and dopamine_transporters .
23161550	0	cocaine	59,66	dopamine_transporter	19,39	cocaine	dopamine transporter	MESH:D003042	24898(Tax:10116)	Chemical	Gene	analog|compound|START_ENTITY binding|nsubj|analog serine|xcomp|binding serine|nsubj|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation of dopamine_transporter serine 7 modulates cocaine analog binding .
23402315	0	cocaine	60,67	dopamine_transporter	96,116	cocaine	dopamine transporter	MESH:D003042	36849(Tax:7227)	Chemical	Gene	effect|nmod|START_ENTITY blocks|dobj|effect blocks|nmod|uptake uptake|nmod|END_ENTITY	Oral administration of methylphenidate blocks the effect of cocaine on uptake at the Drosophila dopamine_transporter .
23612854	0	cocaine	96,103	dopamine_transporter	134,154	cocaine	dopamine transporter	MESH:D003042	24898(Tax:10116)	Chemical	Gene	produced|nmod|START_ENTITY produced|ccomp|tolerant tolerant|xcomp|END_ENTITY	Relations between stimulation of mesolimbic dopamine and place conditioning in rats produced by cocaine or drugs that are tolerant to dopamine_transporter conformational change .
23660705	0	cocaine	54,61	dopamine_transporter	103,123	cocaine	dopamine transporter	MESH:D003042	6531	Chemical	Gene	prevents|dobj|START_ENTITY prevents|nmod|END_ENTITY	Adenovirus capsid-based anti-cocaine vaccine prevents cocaine from binding to the nonhuman primate CNS dopamine_transporter .
23719505	0	cocaine	20,27	dopamine_transporter	99,119	cocaine	dopamine transporter	MESH:D003042	6531	Chemical	Gene	intake|compound|START_ENTITY pattern|nmod|intake determines|nsubj|pattern determines|nmod|END_ENTITY	Temporal pattern of cocaine intake determines tolerance vs sensitization of cocaine effects at the dopamine_transporter .
23719505	0	cocaine	76,83	dopamine_transporter	99,119	cocaine	dopamine transporter	MESH:D003042	6531	Chemical	Gene	effects|compound|START_ENTITY sensitization|nmod|effects determines|dobj|sensitization determines|nmod|END_ENTITY	Temporal pattern of cocaine intake determines tolerance vs sensitization of cocaine effects at the dopamine_transporter .
24412674	0	cocaine	107,114	dopamine_transporter	53,73	cocaine	dopamine transporter	MESH:D003042	13162(Tax:10090)	Chemical	Gene	sensitivity|compound|START_ENTITY Behavior|nmod|sensitivity Behavior|nmod|mice mice|nmod|END_ENTITY	Behavior of knock-in mice with a cocaine-insensitive dopamine_transporter after virogenetic restoration of cocaine sensitivity in the striatum .
24566123	0	cocaine	13,20	dopamine_transporter	92,112	cocaine	dopamine transporter	MESH:D003042	6531	Chemical	Gene	self-administration|compound|START_ENTITY produces|nsubj|self-administration produces|nmod|END_ENTITY	Intermittent cocaine self-administration produces sensitization of stimulant effects at the dopamine_transporter .
24576496	0	cocaine	74,81	dopamine_transporter	26,46	cocaine	dopamine transporter	MESH:D003042	6531	Chemical	Gene	regions|nmod|START_ENTITY translocation|compound|regions intracellular|dobj|translocation intracellular|nsubj|changes changes|nmod|END_ENTITY	Conformational changes in dopamine_transporter intracellular regions upon cocaine binding and dopamine translocation .
24673634	0	cocaine	78,85	dopamine_transporter	4,24	cocaine	dopamine transporter	MESH:D003042	13162(Tax:10090)	Chemical	Gene	affects|nmod|START_ENTITY affects|nsubj|level level|compound|END_ENTITY	The dopamine_transporter expression level differentially affects responses to cocaine and amphetamine .
25179220	0	cocaine	58,65	dopamine_transporter	128,148	cocaine	dopamine transporter	MESH:D003042	24898(Tax:10116)	Chemical	Gene	RTI_82|compound|START_ENTITY docking|nmod|RTI_82 demonstrates|nsubj|docking demonstrates|dobj|positioning positioning|nmod|site site|amod|END_ENTITY	Computational and biochemical docking of the irreversible cocaine analog RTI_82 directly demonstrates ligand positioning in the dopamine_transporter central substrate-binding site .
25850966	0	cocaine	98,105	dopamine_transporter	25,45	cocaine	dopamine transporter	MESH:D003042	6531	Chemical	Gene	responses|nmod|START_ENTITY influences|dobj|responses influences|nsubj|variation variation|nmod|END_ENTITY	Genetic variation of the dopamine_transporter -LRB- DAT1 -RRB- influences the acute subjective responses to cocaine in volunteers with cocaine_use_disorders .
25850966	0	cocaine	98,105	dopamine_transporter	25,45	cocaine	dopamine transporter	MESH:D003042	6531	Chemical	Gene	responses|nmod|START_ENTITY influences|dobj|responses influences|nsubj|variation variation|nmod|END_ENTITY	Genetic variation of the dopamine_transporter -LRB- DAT1 -RRB- influences the acute subjective responses to cocaine in volunteers with cocaine_use_disorders .
7996484	0	cocaine	14,21	dopamine_transporter	47,67	cocaine	dopamine transporter	MESH:D003042	6531	Chemical	Gene	sites|compound|START_ENTITY sites|nmod|END_ENTITY	High affinity cocaine recognition sites on the dopamine_transporter are elevated in fatal cocaine_overdose victims .
8627383	0	cocaine	104,111	dopamine_transporter	56,76	cocaine	dopamine transporter	MESH:D003042	24898(Tax:10116)	Chemical	Gene	self-administration|compound|START_ENTITY altered|nmod|self-administration altered|nsubjpass|transporter transporter|nmod|contrast contrast|nmod|END_ENTITY	The vesicular monoamine transporter , in contrast to the dopamine_transporter , is not altered by chronic cocaine self-administration in the rat .
8657833	0	cocaine	113,120	dopamine_transporter	70,90	cocaine	dopamine transporter	MESH:D003042	6531	Chemical	Gene	addicts|compound|START_ENTITY availability|nmod|addicts availability|compound|END_ENTITY	Euphorigenic doses of cocaine reduce -LSB- 123I -RSB- beta-CIT SPECT measures of dopamine_transporter availability in human cocaine addicts .
8657833	0	cocaine	22,29	dopamine_transporter	70,90	cocaine	dopamine transporter	MESH:D003042	6531	Chemical	Gene	doses|nmod|START_ENTITY reduce|nsubj|doses reduce|dobj|measures measures|nmod|availability availability|compound|END_ENTITY	Euphorigenic doses of cocaine reduce -LSB- 123I -RSB- beta-CIT SPECT measures of dopamine_transporter availability in human cocaine addicts .
8866704	0	cocaine	10,17	dopamine_transporter	21,41	cocaine	dopamine transporter	MESH:D003042	24898(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|receptors receptors|compound|END_ENTITY	Effect of cocaine on dopamine_transporter receptors depends on routes of chronic cocaine administration .
8866704	0	cocaine	81,88	dopamine_transporter	21,41	cocaine	dopamine transporter	MESH:D003042	24898(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY routes|nmod|administration depends|nmod|routes depends|nsubj|Effect Effect|nmod|cocaine cocaine|nmod|receptors receptors|compound|END_ENTITY	Effect of cocaine on dopamine_transporter receptors depends on routes of chronic cocaine administration .
8922687	0	cocaine	20,27	dopamine_transporter	77,97	cocaine	dopamine transporter	MESH:D003042	574143(Tax:9544)	Chemical	Gene	exposure|compound|START_ENTITY Effects|nmod|exposure encoding|nsubj|Effects encoding|dobj|END_ENTITY	Effects of in utero cocaine exposure on the expression of mRNAS encoding the dopamine_transporter and the D1 , D2 and D5 dopamine receptor subtypes in fetal rhesus_monkey .
8961269	0	cocaine	69,76	dopamine_transporter	120,140	cocaine	dopamine transporter	MESH:D003042	24898(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|modulation modulation|compound|END_ENTITY	In vivo regulation of central nervous system progesterone_receptors : cocaine induces steroid-dependent behavior through dopamine_transporter modulation of D5 receptors in rats .
9097405	0	cocaine	88,95	dopamine_transporter	16,36	cocaine	dopamine transporter	MESH:D003042	24898(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY effects|nmod|administration mapping|appos|effects Quantitation|dep|mapping Quantitation|nmod|mRNA mRNA|compound|END_ENTITY	Quantitation of dopamine_transporter mRNA in the rat brain : mapping , effects of `` binge '' cocaine administration and withdrawal .
9098547	0	cocaine	19,26	dopamine_transporter	45,65	cocaine	dopamine transporter	MESH:D003042	24898(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY administration|nmod|mRNA mRNA|compound|END_ENTITY	Effects of chronic cocaine administration on dopamine_transporter mRNA and protein in the rat .
9215601	0	cocaine	32,39	dopamine_transporter	91,111	cocaine	dopamine transporter	MESH:D003042	24898(Tax:10116)	Chemical	Gene	effects|nmod:poss|START_ENTITY approach|nmod|effects approach|parataxis|targeting targeting|dobj|END_ENTITY	Direct approach for attenuating cocaine 's effects on extracellular dopamine : targeting the dopamine_transporter .
9450511	0	cocaine	44,51	dopamine_transporter	10,30	cocaine	dopamine transporter	MESH:D003042	6531	Chemical	Gene	occupancy|nmod|START_ENTITY occupancy|compound|END_ENTITY	Measuring dopamine_transporter occupancy by cocaine in vivo : radiotracer considerations .
9513737	0	cocaine	61,68	dopamine_transporter	33,53	cocaine	dopamine transporter	MESH:D003042	6531	Chemical	Gene	withdrawal|compound|START_ENTITY END_ENTITY|nmod|withdrawal	Plasma homovanillic_acid and the dopamine_transporter during cocaine withdrawal .
9676890	0	cocaine	105,112	dopamine_transporter	32,52	cocaine	dopamine transporter	MESH:D003042	6531	Chemical	Gene	addicts|compound|START_ENTITY administration|nmod|addicts -RSB-|nmod|administration -RSB-|dobj|imaging imaging|nmod|availability availability|compound|END_ENTITY	-LSB- 123I -RSB- beta-CIT SPECT imaging of dopamine_transporter availability after mazindol administration in human cocaine addicts .
8799693	0	cocaine	14,21	growth_hormone	32,46	cocaine	growth hormone	MESH:D003042	81668(Tax:10116)	Chemical	Gene	impact|nmod|START_ENTITY END_ENTITY|nsubj|impact	The impact of cocaine on plasma growth_hormone levels in the adult male rat .
17072589	0	cocaine	45,52	histidine_decarboxylase	56,79	cocaine	histidine decarboxylase	MESH:D003042	15186(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	The psychostimulant and rewarding effects of cocaine in histidine_decarboxylase knockout mice do not support the hypothesis of an inhibitory function of histamine on reward .
21399909	0	cocaine	6,13	interleukin-1b	24,38	cocaine	interleukin-1b	MESH:D003042	24494(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|mRNA mRNA|amod|END_ENTITY	Acute cocaine increases interleukin-1b mRNA and immunoreactive cells in the cortex and nucleus accumbens .
10215654	0	cocaine	59,66	luteinizing_hormone-releasing_hormone	11,48	cocaine	luteinizing hormone-releasing hormone	MESH:D003042	613033(Tax:9544)	Chemical	Gene	levels|compound|START_ENTITY Effects|nmod|levels Effects|nmod|END_ENTITY	Effects of luteinizing_hormone-releasing_hormone on plasma cocaine levels in rhesus_monkeys .
17068774	0	cocaine	25,32	mu_opioid_receptor	51,69	cocaine	mu opioid receptor	MESH:D003042	18390(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of acute `` binge '' cocaine on mRNA levels of mu_opioid_receptor and neuropeptides in dopamine D1_or_D3_receptor knockout mice .
17543182	9	cocaine	1616,1623	nafadotride	1626,1637	cocaine	GABAAalpha1	MESH:D003042	14394(Tax:10090)	Chemical	Gene	group|compound|START_ENTITY group|compound|END_ENTITY	However , the levels of Jak2 increased in cocaine + nafadotride group compared with cocaine group , while remained at basal level in nafadotride group .
16757018	0	cocaine	55,62	neurokinin-1_receptor	19,40	cocaine	neurokinin-1 receptor	MESH:D003042	24807(Tax:10116)	Chemical	Gene	antagonism|nmod|START_ENTITY antagonism|amod|END_ENTITY	Effects of central neurokinin-1_receptor antagonism on cocaine - and opiate-induced locomotor activity and self-administration behaviour in rats .
11525773	0	cocaine	34,41	neurotensin	8,19	cocaine	neurotensin	MESH:D003042	4922	Chemical	Gene	hyperactivity|amod|START_ENTITY blocks|dobj|hyperactivity blocks|nsubj|analog analog|compound|END_ENTITY	A novel neurotensin analog blocks cocaine - and D-amphetamine-induced hyperactivity .
16010538	0	cocaine	55,62	neurotensin	22,33	cocaine	neurotensin	MESH:D003042	299757(Tax:10116)	Chemical	Gene	reinstates|dobj|START_ENTITY reinstates|nsubj|Activation Activation|nmod|receptors receptors|compound|END_ENTITY	Activation of central neurotensin receptors reinstates cocaine seeking in the rat : modulation by a D1/D5 , but not D2/D3 , receptor antagonist .
1821482	0	cocaine	49,56	neurotensin	64,75	cocaine	neurotensin	MESH:D003042	299757(Tax:10116)	Chemical	Gene	administration|nmod|START_ENTITY modify|nsubj|administration modify|dobj|END_ENTITY	Chronic cocaine administration and withdrawal of cocaine modify neurotensin binding in rat brain .
1821482	0	cocaine	8,15	neurotensin	64,75	cocaine	neurotensin	MESH:D003042	299757(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY modify|nsubj|administration modify|dobj|END_ENTITY	Chronic cocaine administration and withdrawal of cocaine modify neurotensin binding in rat brain .
21323925	0	cocaine	108,115	neurotensin	37,48	cocaine	neurotensin	MESH:D003042	299757(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY comparison|nmod|treatment alters|parataxis|comparison alters|dobj|systems systems|compound|END_ENTITY	Methylphenidate alters basal ganglia neurotensin systems through dopaminergic mechanisms : a comparison with cocaine treatment .
21720755	0	cocaine	74,81	neurotensin	11,22	cocaine	neurotensin	MESH:D003042	67405(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|knockout knockout|compound|END_ENTITY	Effects of neurotensin gene knockout in mice on the behavioral effects of cocaine .
7865101	0	cocaine	104,111	neurotensin	46,57	cocaine	neurotensin	MESH:D003042	299757(Tax:10116)	Chemical	Gene	sensitization|compound|START_ENTITY development|nmod|sensitization antagonist|xcomp|development antagonist|nsubj|END_ENTITY	Preexposure to , but not cotreatment with , the neurotensin antagonist SR_48692 delays the development of cocaine sensitization .
9073175	0	cocaine	8,15	neurotensin	26,37	cocaine	neurotensin	MESH:D003042	299757(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Chronic cocaine increases neurotensin gene expression in the shell of the nucleus accumbens and in discrete regions of the striatum .
9718595	0	cocaine	79,86	neurotensin	19,30	cocaine	neurotensin	MESH:D003042	299757(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nmod|effects	Role of endogenous neurotensin in the behavioral and neuroendocrine effects of cocaine .
14717603	0	cocaine	57,64	nicotinic_acetylcholine_receptor	109,141	cocaine	nicotinic acetylcholine receptor	MESH:D003042	1137	Chemical	Gene	inhibition|compound|START_ENTITY approach|nmod|inhibition approach|nmod|END_ENTITY	Mechanism-based approach to the successful prevention of cocaine inhibition of the neuronal -LRB- alpha 3 beta 4 -RRB- nicotinic_acetylcholine_receptor .
15798902	0	cocaine	64,71	nicotinic_acetylcholine_receptor	101,133	cocaine	nicotinic acetylcholine receptor	MESH:D003042	1137	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	Selection of 2 ' - fluoro-modified RNA aptamers for alleviation of cocaine and MK-801 inhibition of the nicotinic_acetylcholine_receptor .
17530475	0	cocaine	84,91	nicotinic_acetylcholine_receptor	4,36	cocaine	nicotinic acetylcholine receptor	MESH:D003042	170945(Tax:10116)	Chemical	Gene	self-administration|compound|START_ENTITY escalation|nmod|self-administration prevents|dobj|escalation prevents|nsubj|mecamylamine mecamylamine|compound|END_ENTITY	The nicotinic_acetylcholine_receptor antagonist mecamylamine prevents escalation of cocaine self-administration in rats with extended daily access .
11082428	0	cocaine	54,61	norepinephrine_transporter	24,50	cocaine	norepinephrine transporter	MESH:D003042	6530	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of the human norepinephrine_transporter by cocaine and amphetamine .
12514195	0	cocaine	8,15	norepinephrine_transporter	52,78	cocaine	norepinephrine transporter	MESH:D003042	613238(Tax:9544)	Chemical	Gene	self-administration|compound|START_ENTITY upregulates|nsubj|self-administration upregulates|dobj|activity activity|amod|functional functional|dep|END_ENTITY	Chronic cocaine self-administration upregulates the norepinephrine_transporter and alters functional activity in the bed nucleus of the stria terminalis of the rhesus_monkey .
12573515	0	cocaine	107,114	norepinephrine_transporter	26,52	cocaine	norepinephrine transporter	MESH:D003042	20538(Tax:10090)	Chemical	Gene	anesthetics|compound|START_ENTITY participates|nmod|anesthetics participates|nsubj|inhibition inhibition|nmod|END_ENTITY	Chronic inhibition of the norepinephrine_transporter in the brain participates in seizure sensitization to cocaine and local anesthetics .
15113605	0	cocaine	10,17	norepinephrine_transporter	46,72	cocaine	norepinephrine transporter	MESH:D003042	83511(Tax:10116)	Chemical	Gene	exposure|compound|START_ENTITY reduces|nsubj|exposure reduces|dobj|function function|compound|END_ENTITY	Perinatal cocaine exposure reduces myocardial norepinephrine_transporter function in the neonatal rat .
18824182	0	cocaine	79,86	norepinephrine_transporter	30,56	cocaine	norepinephrine transporter	MESH:D003042	20538(Tax:10090)	Chemical	Gene	inhibition|compound|START_ENTITY reduce|nmod|inhibition reduce|nsubj|mutations mutations|nmod|END_ENTITY	Functional mutations in mouse norepinephrine_transporter reduce sensitivity to cocaine inhibition .
21420984	0	cocaine	79,86	norepinephrine_transporter	31,57	cocaine	norepinephrine transporter	MESH:D003042	6530	Chemical	Gene	RTI-113|compound|START_ENTITY group|nmod|RTI-113 151|nmod|group 151|nmod|END_ENTITY	Interaction of tyrosine 151 in norepinephrine_transporter with the 2b group of cocaine analog RTI-113 .
1424089	0	cocaine	10,17	ornithine_decarboxylase	42,65	cocaine	ornithine decarboxylase	MESH:D003042	421937(Tax:9031)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	Effect of cocaine , ethanol or nicotine on ornithine_decarboxylase activity in early chick embryo brain .
2386082	0	cocaine	74,81	ornithine_decarboxylase	9,32	cocaine	ornithine decarboxylase	MESH:D003042	4953	Chemical	Gene	exposure|nmod|START_ENTITY levels|nmod|exposure END_ENTITY|dobj|levels	Cerebral ornithine_decarboxylase levels following gestational exposure to cocaine .
8123293	0	cocaine	9,16	ornithine_decarboxylase	43,66	cocaine	ornithine decarboxylase	MESH:D003042	4953	Chemical	Gene	exposure|compound|START_ENTITY alters|nsubj|exposure alters|dobj|activity activity|compound|END_ENTITY	Prenatal cocaine exposure alters postnatal ornithine_decarboxylase activity in rabbit brain .
8353157	0	cocaine	17,24	ornithine_decarboxylase	28,51	cocaine	ornithine decarboxylase	MESH:D003042	24609(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Acute effects of cocaine on ornithine_decarboxylase activity in fetal and neonatal rat heart : evidence for cardiotoxicity .
8420640	0	cocaine	9,16	ornithine_decarboxylase	71,94	cocaine	ornithine decarboxylase	MESH:D003042	24609(Tax:10116)	Chemical	Gene	START_ENTITY|dep|effects effects|nmod|END_ENTITY	Prenatal cocaine and cell development in rat brain regions : effects on ornithine_decarboxylase and macromolecules .
8456117	0	cocaine	39,46	ornithine_decarboxylase	85,108	cocaine	ornithine decarboxylase	MESH:D003042	4953	Chemical	Gene	induced|nmod|START_ENTITY inhibition|acl|induced associated|nsubjpass|inhibition associated|nmod|suppression suppression|nmod|activity activity|amod|END_ENTITY	Embryonic growth inhibition induced by cocaine is associated with the suppression of ornithine_decarboxylase activity .
22504589	0	cocaine	100,107	preproenkephalin	121,137	cocaine	preproenkephalin	MESH:D003042	18619(Tax:10090)	Chemical	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	Effects of withdrawal from chronic escalating-dose binge cocaine on conditioned place preference to cocaine and striatal preproenkephalin mRNA in C57BL/6J mice .
22504589	0	cocaine	57,64	preproenkephalin	121,137	cocaine	preproenkephalin	MESH:D003042	18619(Tax:10090)	Chemical	Gene	withdrawal|nmod|START_ENTITY Effects|nmod|withdrawal place|nsubj|Effects place|nmod|mRNA mRNA|compound|END_ENTITY	Effects of withdrawal from chronic escalating-dose binge cocaine on conditioned place preference to cocaine and striatal preproenkephalin mRNA in C57BL/6J mice .
12786988	0	cocaine	73,80	prodynorphin	25,37	cocaine	prodynorphin	MESH:D003042	5173	Chemical	Gene	self-administration|compound|START_ENTITY striatum|nmod|self-administration striatum|nsubj|upregulation upregulation|nmod|mRNA mRNA|compound|END_ENTITY	Temporal upregulation of prodynorphin mRNA in the primate striatum after cocaine self-administration .
7694032	0	cocaine	8,15	prodynorphin	63,75	cocaine	prodynorphin	MESH:D003042	29190(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY induces|nsubj|administration induces|dobj|increase increase|nmod|mRNA mRNA|compound|END_ENTITY	` Binge ' cocaine administration induces a sustained increase of prodynorphin mRNA in rat caudate-putamen .
8840025	0	cocaine	32,39	prodynorphin	63,75	cocaine	prodynorphin	MESH:D003042	29190(Tax:10116)	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|expression expression|compound|END_ENTITY	Chronic intracerebroventricular cocaine differentially affects prodynorphin gene expression in rat hypothalamus and caudate-putamen .
9795151	0	cocaine	10,17	prodynorphin	46,58	cocaine	prodynorphin	MESH:D003042	29190(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|ccomp|shell shell|nsubj|expression expression|nmod|mRNA mRNA|compound|END_ENTITY	Perinatal cocaine decreases the expression of prodynorphin mRNA in nucleus accumbens shell in the adult rat .
10349036	0	cocaine	25,32	prolactin	42,51	cocaine	prolactin	MESH:D003042	5617	Chemical	Gene	addicts|compound|START_ENTITY function|nmod|addicts function|dep|responses responses|compound|END_ENTITY	Serotonergic function in cocaine addicts : prolactin responses to sequential D,L-fenfluramine challenges .
11750871	0	cocaine	11,18	prolactin	42,51	cocaine	prolactin	MESH:D003042	707052(Tax:9544)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|compound|END_ENTITY	Effects of cocaine on basal and pulsatile prolactin levels in rhesus_monkeys .
17000009	0	cocaine	135,142	prolactin	65,74	cocaine	prolactin	MESH:D003042	5617	Chemical	Gene	meta-chlorophenylpiperazine|nmod|START_ENTITY moderators|acl|meta-chlorophenylpiperazine moderators|nmod|response response|compound|END_ENTITY	Polymorphism in the serotonin_transporter gene and moderators of prolactin response to meta-chlorophenylpiperazine in African-American cocaine abusers and controls .
18321529	0	cocaine	100,107	prolactin	47,56	cocaine	prolactin	MESH:D003042	5617	Chemical	Gene	dependence|compound|START_ENTITY meta-chlorophenylpiperazine|nmod|dependence Relationship|acl|meta-chlorophenylpiperazine Relationship|nmod|serotonin_transporter serotonin_transporter|nmod|response response|compound|END_ENTITY	Relationship of the serotonin_transporter with prolactin response to meta-chlorophenylpiperazine in cocaine dependence .
2118570	0	cocaine	17,24	prolactin	28,37	cocaine	prolactin	MESH:D003042	707052(Tax:9544)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Acute effects of cocaine on prolactin and gonadotropins in female rhesus_monkey during the follicular phase of the menstrual cycle .
2159825	0	cocaine	38,45	prolactin	67,76	cocaine	prolactin	MESH:D003042	24683(Tax:10116)	Chemical	Gene	infusions|nmod|START_ENTITY alter|nsubj|infusions alter|dobj|release release|nmod|END_ENTITY	Multiple , but not acute , infusions of cocaine alter the release of prolactin in male rats .
2343924	0	cocaine	39,46	prolactin	6,15	cocaine	prolactin	MESH:D003042	5617	Chemical	Gene	abstinence|compound|START_ENTITY Serum|nmod|abstinence Serum|dobj|levels levels|compound|END_ENTITY	Serum prolactin levels during extended cocaine abstinence .
7932159	0	cocaine	52,59	prolactin	23,32	cocaine	prolactin	MESH:D003042	707052(Tax:9544)	Chemical	Gene	self-administration|compound|START_ENTITY interactions|nmod|self-administration Effects|dep|interactions Effects|nmod|dopamine dopamine|nmod|END_ENTITY	Effects of dopamine on prolactin : interactions with cocaine self-administration by female rhesus_monkeys .
8587974	0	cocaine	9,16	prolactin	56,65	cocaine	prolactin	MESH:D003042	24683(Tax:10116)	Chemical	Gene	produces|nsubj|START_ENTITY produces|dobj|suppression suppression|nmod|END_ENTITY	Prenatal cocaine produces dose-dependent suppression of prolactin and growth_hormone in neonatal rats .
9727959	0	cocaine	105,112	prolactin	42,51	cocaine	prolactin	MESH:D003042	5617	Chemical	Gene	addicts|compound|START_ENTITY meta-chlorophenylpiperazine|nmod|addicts associated|xcomp|meta-chlorophenylpiperazine associated|nmod|response response|compound|END_ENTITY	Hostility is associated with a heightened prolactin response to meta-chlorophenylpiperazine in abstinent cocaine addicts .
11062247	0	cocaine	36,43	serotonin_transporter	66,87	cocaine	serotonin transporter	MESH:D003042	25553(Tax:10116)	Chemical	Gene	pocket|compound|START_ENTITY pocket|nmod|END_ENTITY	Biophysical characterization of the cocaine binding pocket in the serotonin_transporter using a fluorescent cocaine analogue as a molecular reporter .
15547786	0	cocaine	64,71	sigma1_receptor	19,34	cocaine	sigma1 receptor	MESH:D003042	18391(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY Involvement|nmod|effects Involvement|nmod|END_ENTITY	Involvement of the sigma1_receptor in the appetitive effects of cocaine .
1686936	0	cocaine	33,40	somatostatin	53,65	cocaine	somatostatin	MESH:D003042	24797(Tax:10116)	Chemical	Gene	exposure|compound|START_ENTITY Effect|nmod|exposure Effect|nmod|END_ENTITY	Effect of prenatal and postnatal cocaine exposure on somatostatin content and binding in frontoparietal cortex and hippocampus of developing rat pups .
10612702	0	cocaine	13,20	thyrotropin-releasing_hormone	105,134	cocaine	thyrotropin-releasing hormone	MESH:D003042	22044(Tax:10090)	Chemical	Gene	START_ENTITY|dep|relationship relationship|nmod|hormone hormone|amod|END_ENTITY	Hypothalamic cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- neurons : histochemical relationship to thyrotropin-releasing_hormone , melanin-concentrating hormone , orexin/hypocretin and neuropeptide_Y .
15003716	0	cocaine	84,91	thyrotropin-releasing_hormone	10,39	cocaine	thyrotropin-releasing hormone	MESH:D003042	25569(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of thyrotropin-releasing_hormone on the locomotor and sensitizing effects of cocaine in rats .
15047018	0	cocaine	47,54	thyrotropin-releasing_hormone	123,152	cocaine	thyrotropin-releasing hormone	MESH:D003042	7200	Chemical	Gene	START_ENTITY|dep|innervation innervation|nmod|neurons neurons|amod|END_ENTITY	Medullary adrenergic neurons contribute to the cocaine - _ and_amphetamine-regulated_transcript-immunoreactive innervation of thyrotropin-releasing_hormone synthesizing neurons in the hypothalamic paraventricular nucleus .
15680956	0	cocaine	52,59	thyrotropin-releasing_hormone	120,149	cocaine	thyrotropin-releasing hormone	MESH:D003042	7200	Chemical	Gene	afferents|nmod|START_ENTITY contribution|nmod|afferents contribution|dep|innervation innervation|nmod|neurons neurons|amod|END_ENTITY	Relative contribution of brainstem afferents to the cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- innervation of thyrotropin-releasing_hormone synthesizing neurons in the hypothalamic paraventricular nucleus -LRB- PVN -RRB- .
9243522	0	cocaine	20,27	thyrotropin-releasing_hormone	50,79	cocaine	thyrotropin-releasing hormone	MESH:D003042	25569(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY Effects|nmod|administration Effects|nmod|level level|amod|END_ENTITY	Effects of repeated cocaine administration on the thyrotropin-releasing_hormone level and receptors in the rat brain .
1717622	0	cocaine	71,78	tumor_necrosis_factor	14,35	cocaine	tumor necrosis factor	MESH:D003042	21926(Tax:10090)	Chemical	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	Modulation of tumor_necrosis_factor and gamma interferon production by cocaine and morphine in aging mice infected with LP-BM5 , a murine retrovirus .
22056598	0	cocaine	34,41	zif268	67,73	cocaine	zif268	MESH:D003042	24330(Tax:10116)	Chemical	Gene	reward|compound|START_ENTITY reward|nmod|END_ENTITY	Juvenile and adult rats differ in cocaine reward and expression of zif268 in the forebrain .
17996706	0	cochaperone	22,33	Hsp70	60,65	cochaperone	Hsp70	null	3308	Chemical	Gene	START_ENTITY|dobj|binding binding|nmod|END_ENTITY	Structural basis of J cochaperone binding and regulation of Hsp70 .
23740762	0	cochaperone	17,28	SGTA	29,33	cochaperone	SGTA	null	6449	Chemical	Gene	results|amod|START_ENTITY results|compound|END_ENTITY	Knockdown of the cochaperone SGTA results in the suppression of androgen and PI3K/Akt signaling and inhibition of prostate_cancer cell proliferation .
11738548	0	cochaperones	16,28	BAG-1	0,5	cochaperones	BAG-1	null	573	Chemical	Gene	family|nmod|START_ENTITY family|compound|END_ENTITY	BAG-1 family of cochaperones in the modulation of nuclear receptor action .
8823235	0	codeine	27,34	CYP2D6	68,74	codeine	CYP2D6	MESH:D003061	1565	Chemical	Gene	Formation|nmod|START_ENTITY Formation|nmod|subjects subjects|nmod|genotypes genotypes|compound|END_ENTITY	Formation of morphine from codeine in Chinese subjects of different CYP2D6 genotypes .
23643712	0	coenzyme_A_esters	96,113	N-acetylglutamate_synthase	14,40	coenzyme A esters	N-acetylglutamate synthase	null	162417	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of N-acetylglutamate_synthase by various monocarboxylic and dicarboxylic short-chain coenzyme_A_esters and the production of alternative glutamate_esters .
27047809	0	coenzyme_Q10	11,23	C-reactive_protein	43,61	coenzyme Q10	C-reactive protein	MESH:C024989	1401	Chemical	Gene	supplementation|amod|START_ENTITY supplementation|nmod|END_ENTITY	Effects of coenzyme_Q10 supplementation on C-reactive_protein and homocysteine as the inflammatory markers in hemodialysis patients ; a randomized clinical trial .
17268082	0	coenzyme_Q10	10,22	CEA	55,58	coenzyme Q10	CEA	MESH:C024989	1084	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of coenzyme_Q10 , riboflavin and niacin on serum CEA and CA_15-3 levels in breast_cancer patients undergoing tamoxifen therapy .
18656939	0	coenzyme_Q10	15,27	P-glycoprotein	65,79	coenzyme Q10	P-glycoprotein	MESH:C024989	5243	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of coenzyme_Q10 with the intestinal drug transporter P-glycoprotein .
16388100	0	coenzyme_Q10	10,22	catalase	26,34	coenzyme Q10	catalase	MESH:C024989	24248(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effect of coenzyme_Q10 on catalase activity and other antioxidant parameters in streptozotocin-induced diabetic rats .
24513070	0	coenzyme_Q10	11,23	tumor_necrosis_factor-a	45,68	coenzyme Q10	tumor necrosis factor-a	MESH:C024989	24835(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of coenzyme_Q10 on the expression of tumor_necrosis_factor-a and interleukin-10 in gingival tissue of experimental periodontitis in rats -RSB- .
25450583	0	coenzyme_Q10	5,17	vaspin	102,108	coenzyme Q10	vaspin	MESH:C024989	145264	Chemical	Gene	supplementation|amod|START_ENTITY supplementation|dep|effects effects|nmod|END_ENTITY	Oral coenzyme_Q10 supplementation in patients with nonalcoholic fatty liver disease : effects on serum vaspin , chemerin , pentraxin_3 , insulin resistance and oxidative stress .
25450583	0	coenzyme_Q10	5,17	vaspin	102,108	coenzyme Q10	vaspin	MESH:C024989	145264	Chemical	Gene	supplementation|amod|START_ENTITY supplementation|dep|effects effects|nmod|END_ENTITY	Oral coenzyme_Q10 supplementation in patients with nonalcoholic fatty liver disease : effects on serum vaspin , chemerin , pentraxin_3 , insulin resistance and oxidative stress .
11697042	0	coformycin	56,66	adenosine_deaminase	127,146	coformycin	adenosine deaminase	MESH:D003070	280712(Tax:9913)	Chemical	Gene	analogue|compound|START_ENTITY thermodynamics|nmod|analogue END_ENTITY|nsubj|thermodynamics	Binding thermodynamics of the transition state analogue coformycin and of the ground state analogue 1-deazaadenosine to bovine adenosine_deaminase .
12420753	0	coformycin	71,81	adenosine_deaminase	92,111	coformycin	adenosine deaminase	MESH:D003070	280712(Tax:9913)	Chemical	Gene	binding|nmod|START_ENTITY measurement|nmod|binding measurement|nmod|END_ENTITY	Direct measurement of local and global contributions in the binding of coformycin to bovine adenosine_deaminase .
1262787	0	coformycin	59,69	adenosine_deaminase	98,117	coformycin	adenosine deaminase	MESH:D003070	100	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Inhibition of maturation of human precursor lymphocytes by coformycin , an inhibitor of the enzyme adenosine_deaminase .
15043152	0	coformycin	105,115	adenosine_deaminase	14,33	coformycin	adenosine deaminase	MESH:D003070	100	Chemical	Gene	studies|nmod|START_ENTITY Inhibitors|dep|studies Inhibitors|nmod|END_ENTITY	Inhibitors of adenosine_deaminase : continued studies of structure-activity relationships in analogues of coformycin .
6072897	0	coformycin	22,32	adenosine_deaminase	36,55	coformycin	adenosine deaminase	MESH:D003070	100	Chemical	Gene	Mode|nmod|START_ENTITY Mode|nmod|END_ENTITY	Mode of inhibition of coformycin on adenosine_deaminase .
7103613	0	coformycin	71,81	adenosine_deaminase	107,126	coformycin	adenosine deaminase	MESH:D003070	100720869	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Potentiation of the myocardial actions of adenosine in the presence of coformycin , a specific inhibitor of adenosine_deaminase .
1764117	0	colchicine	10,20	CCl4	50,54	colchicine	CCl4	MESH:D003078	116637(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|function function|nmod|END_ENTITY	Effect of colchicine on hepatobiliary function in CCl4 treated rats .
7745225	0	colchicine	21,31	CCl4	65,69	colchicine	CCl4	MESH:D003078	6351	Chemical	Gene	effect|nmod|START_ENTITY induced|nsubj|effect induced|nmod|END_ENTITY	Protective effect of colchicine on acute_liver_damage induced by CCl4 .
14963695	0	colchicine	15,25	COX-1	73,78	colchicine	COX-1	MESH:D003078	4512	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of colchicine and hydroxychloroquine on the cyclo-oxygenases COX-1 and COX-2 .
18080195	0	colchicine	26,36	FMF	62,65	colchicine	FMF	MESH:D003078	4210	Chemical	Gene	therapy|amod|START_ENTITY therapy|nmod|patients patients|nmod|END_ENTITY	Gastric changes following colchicine therapy in patients with FMF .
22884555	0	colchicine	23,33	FMF	54,57	colchicine	FMF	MESH:D003078	4210	Chemical	Gene	START_ENTITY|nmod|patients patients|compound|END_ENTITY	Incomplete response to colchicine in M694V homozygote FMF patients .
23432575	0	colchicine	83,93	Familial_Mediterranean_Fever	31,59	colchicine	Familial Mediterranean Fever	MESH:D003078	4210	Chemical	Gene	effect|nmod|START_ENTITY dynamics|dep|effect dynamics|nmod|END_ENTITY	Neutrophil F-actin dynamics in Familial_Mediterranean_Fever : the unequal effect of colchicine on activated neutrophils .
24740462	0	colchicine	23,33	Familial_Mediterranean_fever	51,79	colchicine	Familial Mediterranean fever	MESH:D003078	4210	Chemical	Gene	validity|nmod|START_ENTITY validity|nmod|patients patients|nmod|END_ENTITY	Diagnostic validity of colchicine in patients with Familial_Mediterranean_fever .
12507392	0	colchicine	28,38	Fos	47,50	colchicine	Fos	MESH:D003078	314322(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Dexamethasone attenuates by colchicine induced Fos expression in the rat deep cerebellar and vestibular nuclei .
12788208	0	colchicine	99,109	Fos	0,3	colchicine	Fos	MESH:D003078	314322(Tax:10116)	Chemical	Gene	administration|nmod|START_ENTITY cerebellar|nmod|administration induction|nmod|cerebellar induction|compound|END_ENTITY	Fos induction in the rat deep cerebellar and vestibular nuclei following central administration of colchicine : a qualitative and quantitative time-course study .
22540857	0	colchicine	88,98	Fos	24,27	colchicine	Fos	MESH:D003078	14281(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY impact|dep|effect impact|nmod|expression expression|compound|END_ENTITY	High fat diet impact on Fos expression in ovariectomized female C57BL/6 mice : effect of colchicine and response of different neuronal phenotypes .
11802319	0	colchicine	10,20	MEFV	38,42	colchicine	MEFV	MESH:D003078	4210	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of colchicine and cytokines on MEFV expression and C5a inhibitor activity in human primary fibroblast cultures .
9832207	0	colchicine	125,135	Neuropeptide_Y	0,14	colchicine	Neuropeptide Y	MESH:D003078	24604(Tax:10116)	Chemical	Gene	microinjection|nmod|START_ENTITY induced|nmod|microinjection hyperphagia|acl|induced decreased|nmod|hyperphagia decreased|nsubjpass|release release|amod|END_ENTITY	Neuropeptide_Y release in the paraventricular nucleus is decreased during transient hyperphagia induced by microinjection of colchicine into the ventromedial nucleus of rats .
6991666	0	colchicine	54,64	Renin	0,5	colchicine	Renin	MESH:D003078	24715(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY release|dep|effects release|compound|END_ENTITY	Renin release from isolated rat glomeruli : effects of colchicine , vinca_alkaloids , dimethylsulphoxide , and cytochalasins .
1220688	1	colchicine	99,109	albumin	113,120	colchicine	albumin	MESH:D003078	24186(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|production production|compound|END_ENTITY	The effect of colchicine on albumin production .
1373270	0	colchicine	89,99	amyloid_precursor_protein	16,41	colchicine	amyloid precursor protein	MESH:D003078	54226(Tax:10116)	Chemical	Gene	Accumulation|nmod|START_ENTITY Accumulation|nmod|END_ENTITY	Accumulation of amyloid_precursor_protein in neurons after intraventricular injection of colchicine .
3979951	0	colchicine	15,25	carcinoembryonic_antigen	70,94	colchicine	carcinoembryonic antigen	MESH:D003078	292701(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|excretion excretion|nmod|END_ENTITY	The effects of colchicine and vinblastine on the biliary excretion of carcinoembryonic_antigen .
11144118	0	colchicine	10,20	cytochrome_P450	83,98	colchicine	cytochrome P450	MESH:D003078	4051	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of colchicine and its derivatives on the expression of selected isoforms of cytochrome_P450 in primary cultures of human hepatocytes .
12698329	0	colchicine	12,22	familial_Mediterranean_fever	57,85	colchicine	familial Mediterranean fever	MESH:D003078	4210	Chemical	Gene	therapy|amod|START_ENTITY Efficacy|nmod|therapy Efficacy|nmod|END_ENTITY	Efficacy of colchicine therapy in amyloid_nephropathy of familial_Mediterranean_fever .
14719203	0	colchicine	104,114	familial_Mediterranean_fever	54,82	colchicine	familial Mediterranean fever	MESH:D003078	4210	Chemical	Gene	unresponsive|nmod|START_ENTITY END_ENTITY|amod|unresponsive	Intravenous colchicine for treatment of patients with familial_Mediterranean_fever unresponsive to oral colchicine .
1499522	0	colchicine	41,51	familial_Mediterranean_fever	68,96	colchicine	familial Mediterranean fever	MESH:D003078	4210	Chemical	Gene	effect|amod|START_ENTITY kidney_failure|nmod|effect Toxic_myopathy|nmod|kidney_failure ifn|nsubj|Toxic_myopathy ifn|dobj|-RSB- -RSB-|compound|END_ENTITY	-LSB- Toxic_myopathy with kidney_failure as a colchicine side effect ifn familial_Mediterranean_fever -RSB- .
1859491	0	colchicine	10,20	familial_Mediterranean_fever	48,76	colchicine	familial Mediterranean fever	MESH:D003078	4210	Chemical	Gene	treatment|compound|START_ENTITY treatment|nmod|END_ENTITY	Long-term colchicine treatment in children with familial_Mediterranean_fever .
23206577	0	colchicine	50,60	familial_Mediterranean_fever	105,133	colchicine	familial Mediterranean fever	MESH:D003078	4210	Chemical	Gene	therapy|amod|START_ENTITY profile|nmod|therapy profile|nmod|children children|acl|suffering suffering|nmod|END_ENTITY	The expanded clinical profile and the efficacy of colchicine therapy in Egyptian children suffering from familial_Mediterranean_fever : a descriptive study .
23298502	0	colchicine	20,30	familial_Mediterranean_fever	68,96	colchicine	familial Mediterranean fever	MESH:D003078	4210	Chemical	Gene	Pharmacokinetics|nmod|START_ENTITY Pharmacokinetics|nmod|END_ENTITY	Pharmacokinetics of colchicine in pediatric and adult patients with familial_Mediterranean_fever .
24064013	0	colchicine	18,28	familial_Mediterranean_fever	42,70	colchicine	familial Mediterranean fever	MESH:D003078	4210	Chemical	Gene	treatment|amod|START_ENTITY trends|nmod|treatment trends|nmod|END_ENTITY	Current trends in colchicine treatment in familial_Mediterranean_fever .
24064015	0	colchicine	73,83	familial_Mediterranean_fever	22,50	colchicine	familial Mediterranean fever	MESH:D003078	4210	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|levels levels|nmod|patients patients|compound|END_ENTITY	Vitamin_B12 levels in familial_Mediterranean_fever patients treated with colchicine .
24180297	0	colchicine	33,43	familial_Mediterranean_fever	79,107	colchicine	familial Mediterranean fever	MESH:D003078	4210	Chemical	Gene	START_ENTITY|nmod|patients patients|compound|END_ENTITY	Relationship between response to colchicine treatment and MDR1 polymorphism in familial_Mediterranean_fever patients .
25760087	0	colchicine	62,72	familial_Mediterranean_fever	21,49	colchicine	familial Mediterranean fever	MESH:D003078	4210	Chemical	Gene	resistance|amod|START_ENTITY focusing|nmod|resistance agents|acl|focusing agents|nmod|END_ENTITY	Biological agents in familial_Mediterranean_fever focusing on colchicine resistance and amyloidosis .
26067744	0	colchicine	20,30	familial_Mediterranean_fever	59,87	colchicine	familial Mediterranean fever	MESH:D003078	4210	Chemical	Gene	resistance|amod|START_ENTITY Association|nmod|resistance Association|nmod|END_ENTITY	Association between colchicine resistance and vitamin_D in familial_Mediterranean_fever .
26155193	0	colchicine	104,114	familial_Mediterranean_fever	50,78	colchicine	familial Mediterranean fever	MESH:D003078	4210	Chemical	Gene	Coexistence|acl|START_ENTITY Coexistence|nmod|hereditary_angioedema hereditary_angioedema|nmod|case case|nmod|END_ENTITY	Coexistence of hereditary_angioedema in a case of familial_Mediterranean_fever with partial response to colchicine .
26384820	0	colchicine	14,24	familial_Mediterranean_fever	82,110	colchicine	familial Mediterranean fever	MESH:D003078	4210	Chemical	Gene	severity|compound|START_ENTITY effect|nmod|severity effect|nmod|children children|nmod|END_ENTITY	The effect of colchicine and disease severity on physical growth in children with familial_Mediterranean_fever .
26554556	0	colchicine	54,64	familial_Mediterranean_fever	75,103	colchicine	familial Mediterranean fever	MESH:D003078	4210	Chemical	Gene	resistant|amod|START_ENTITY END_ENTITY|amod|resistant	Intestinal_malrotation as a misdiagnosis of pediatric colchicine resistant familial_Mediterranean_fever .
3426990	0	colchicine	91,101	familial_Mediterranean_fever	49,77	colchicine	familial Mediterranean fever	MESH:D003078	4210	Chemical	Gene	therapy|compound|START_ENTITY history|nmod|therapy history|nmod|patients patients|nmod|END_ENTITY	Fertility and obstetric history in patients with familial_Mediterranean_fever on long-term colchicine therapy .
3752545	0	colchicine	25,35	familial_Mediterranean_fever	79,107	colchicine	familial Mediterranean fever	MESH:D003078	4210	Chemical	Gene	therapy|compound|START_ENTITY effects|nmod|therapy effects|nmod|patients patients|nmod|END_ENTITY	The effects of long-term colchicine therapy on male fertility in patients with familial_Mediterranean_fever .
6461454	0	colchicine	78,88	familial_Mediterranean_fever	46,74	colchicine	familial Mediterranean fever	MESH:D003078	4210	Chemical	Gene	Correction|nmod|START_ENTITY Correction|nmod|END_ENTITY	Correction of a suppressor cell deficiency in familial_Mediterranean_fever by colchicine .
6529602	0	colchicine	76,86	familial_Mediterranean_fever	25,53	colchicine	familial Mediterranean fever	MESH:D003078	4210	Chemical	Gene	therapy|amod|START_ENTITY reaction|nmod|therapy reaction|nmod|END_ENTITY	Inflammatory reaction in familial_Mediterranean_fever -LRB- FMF -RRB- before and with colchicine therapy .
779797	0	colchicine	23,33	familial_Mediterranean_fever	81,109	colchicine	familial Mediterranean fever	MESH:D003078	4210	Chemical	Gene	therapy|compound|START_ENTITY Effect|nmod|therapy function|nsubj|Effect function|nmod|patients patients|nmod|END_ENTITY	Effect of prophylactic colchicine therapy on leukocyte function in patients with familial_Mediterranean_fever .
9143863	0	colchicine	8,18	familial_Mediterranean_fever	66,94	colchicine	familial Mediterranean fever	MESH:D003078	4210	Chemical	Gene	treatment|compound|START_ENTITY impair|nsubj|treatment impair|nmod|patients patients|compound|END_ENTITY	Chronic colchicine treatment does not impair glucose tolerance in familial_Mediterranean_fever patients .
9848464	0	colchicine	87,97	familial_Mediterranean_fever	101,129	colchicine	familial Mediterranean fever	MESH:D003078	4210	Chemical	Gene	START_ENTITY|nmod|inflammatory_diseases inflammatory_diseases|compound|END_ENTITY	Does the lack of the P-glycoprotein efflux pump in neutrophils explain the efficacy of colchicine in familial_Mediterranean_fever and other inflammatory_diseases ?
19505404	0	colchicine	121,131	familial_mediterranean_fever	20,48	colchicine	familial mediterranean fever	MESH:D003078	4210	Chemical	Gene	therapy|amod|START_ENTITY regression|nmod|therapy retroperitoneal_fibrosis|acl|regression Association|dep|retroperitoneal_fibrosis Association|nmod|END_ENTITY	Association between familial_mediterranean_fever and retroperitoneal_fibrosis : retroperitoneal_fibrosis regression after colchicine therapy .
20016916	0	colchicine	14,24	familial_mediterranean_fever	61,89	colchicine	familial mediterranean fever	MESH:D003078	4210	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|children children|nmod|END_ENTITY	The effect of colchicine on physical growth in children with familial_mediterranean_fever .
20563632	0	colchicine	25,35	glutathione_reductase	39,60	colchicine	glutathione reductase	MESH:D003078	2936	Chemical	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	A comparative study with colchicine on glutathione_reductase .
1138898	0	colchicine	102,112	lipoprotein_lipase	54,72	colchicine	lipoprotein lipase	MESH:D003078	24539(Tax:10116)	Chemical	Gene	Interference|nmod|START_ENTITY Interference|nmod|transport transport|nmod|END_ENTITY	Interference with the transport of heparin-releasable lipoprotein_lipase in the perfused rat heart by colchicine and vinblastine .
6872546	0	colchicine	10,20	lipoprotein_lipase	30,48	colchicine	lipoprotein lipase	MESH:D003078	24539(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of colchicine on heart lipoprotein_lipase .
10027552	0	colchicine	10,20	neuropeptide_Y	24,38	colchicine	neuropeptide Y	MESH:D003078	24604(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effect of colchicine on neuropeptide_Y expression in rat dorsal root ganglia and spinal cord .
183512	0	colchicine	10,20	parathyroid_hormone	60,79	colchicine	parathyroid hormone	MESH:D003078	24694(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of colchicine on urinary phosphate and regulation by parathyroid_hormone .
7049920	0	colchicine	10,20	renin	55,60	colchicine	renin	MESH:D003078	24715(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|concentration concentration|compound|END_ENTITY	Effect of colchicine on drug-induced changes in plasma renin concentration in rats .
4367887	0	colchicine	11,21	vasopressin	64,75	colchicine	vasopressin	MESH:D003078	551	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|action action|nmod|END_ENTITY	Effects of colchicine and vinblastine on the cellular action of vasopressin in mammalian kidney .
6272020	0	colchicine	11,21	vasopressin	44,55	colchicine	vasopressin	MESH:D003078	551	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of colchicine and cytochalasin_B on vasopressin - and cyclic_adenosine_monophosphate-induced changes in toad urinary bladder .
26888164	0	colesevelam	66,77	glucagon-like_peptide-1	81,104	colesevelam	glucagon-like peptide-1	MESH:C107058	2641	Chemical	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	The effect of chenodeoxycholic_acid and the bile_acid sequestrant colesevelam on glucagon-like_peptide-1 secretion .
20059361	0	colesevelam_hydrochloride	14,39	insulin	43,50	colesevelam hydrochloride	insulin	MESH:C107058	3630	Chemical	Gene	START_ENTITY|nmod|sensitivity sensitivity|compound|END_ENTITY	The effect of colesevelam_hydrochloride on insulin sensitivity and secretion in patients with type 2 diabetes : a pilot study .
25875530	0	colupulone	51,61	P-glycoprotein	14,28	colupulone	P-glycoprotein	MESH:C075356	5243	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Synthesis and P-glycoprotein induction activity of colupulone analogs .
25875530	0	colupulone	51,61	P-glycoprotein	14,28	colupulone	P-glycoprotein	MESH:C075356	5243	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Synthesis and P-glycoprotein induction activity of colupulone analogs .
11289660	0	compound_aethiopinone	71,92	5-lipoxygenase	14,28	compound aethiopinone	5-lipoxygenase	null	11689(Tax:10090)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activity activity|amod|END_ENTITY	Inhibition of 5-lipoxygenase activity by the natural anti-inflammatory compound_aethiopinone .
7945541	0	coniferyl_alcohol	23,40	5-lipoxygenase	80,94	coniferyl alcohol	5-lipoxygenase	MESH:C010559	240	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|inhibitors inhibitors|nmod|END_ENTITY	1 ' - Hydroxyeugenol - and coniferyl_alcohol derivatives as effective inhibitors of 5-lipoxygenase and Cu -LRB- 2 + -RRB- - mediated low density lipoprotein oxidation .
21648462	0	copper	55,61	APP	106,109	copper	APP	MESH:D003300	351	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Effects of Cu ions and explicit water molecules on the copper binding domain of amyloid_precursor_protein APP -LRB- 131-189 -RRB- : a molecular dynamics study .
25122912	4	copper	629,635	APP	653,656	copper	APP	MESH:D003300	351	Chemical	Gene	binding|compound|START_ENTITY promotes|nsubj|binding promotes|xcomp|interaction interaction|nsubj|END_ENTITY	In coimmunoprecipitation assays copper binding promotes APP interaction , whereas mutations in the copper-binding sites of either the GFLD or CuBD result in a drastic_reduction in APP cis-orientated dimerization .
25557959	0	copper	12,18	APP	68,71	copper	APP	MESH:D003300	11820(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY CUTA|nsubj|role CUTA|nmod|processing processing|compound|END_ENTITY	The role of copper and the copper-related protein CUTA in mediating APP processing and Ab generation .
20045993	0	copper	25,31	ATP7A	71,76	copper	ATP7A	MESH:D003300	538	Chemical	Gene	polymorphisms|nmod|START_ENTITY transporters|nsubj|polymorphisms transporters|dobj|END_ENTITY	Genetic polymorphisms of copper - and platinum drug-efflux transporters ATP7A and ATP7B in Japanese cancer patients .
10217409	0	copper	61,67	ATP7B	96,101	copper	ATP7B	MESH:D003300	24218(Tax:10116)	Chemical	Gene	introduction|nmod|START_ENTITY rat|nmod|introduction rat|xcomp|transporting transporting|dobj|ATPase ATPase|appos|END_ENTITY	Biliary_excretion_of_copper in LEC rat after introduction of copper transporting P-type ATPase , ATP7B .
12701394	0	copper	39,45	ATP7B	74,79	copper	ATP7B	MESH:D003300	540	Chemical	Gene	storage|compound|START_ENTITY storage|amod|due due|nmod|mutations mutations|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- From gene to disease ; Wilson_disease : copper storage due to mutations in ATP7B -RSB- .
12718440	0	copper	24,30	ATP7B	18,23	copper	ATP7B	MESH:D003300	540	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	A mutation in the ATP7B copper transporter causes reduced dopamine_beta-hydroxylase and norepinephrine in mouse adrenal .
12869652	0	copper	4,10	ATP7B	23,28	copper	ATP7B	MESH:D003300	540	Chemical	Gene	export|compound|START_ENTITY pump|nsubj|export pump|ccomp|modulates modulates|nsubj|END_ENTITY	The copper export pump ATP7B modulates the cellular pharmacology of carboplatin in ovarian_carcinoma cells .
14616767	0	copper	52,58	ATP7B	72,77	copper	ATP7B	MESH:D003300	540	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Genetic variation in the promoter and 5 ' UTR of the copper transporter , ATP7B , in patients with Wilson_disease .
15511628	0	copper	15,21	ATP7B	140,145	copper	ATP7B	MESH:D003300	540	Chemical	Gene	metabolism|compound|START_ENTITY Restoration|nmod|metabolism Restoration|nmod|expression expression|nmod|gene gene|compound|END_ENTITY	Restoration of copper metabolism and rescue of hepatic_abnormalities in LEC rats , an animal model of Wilson_disease , by expression of human ATP7B gene .
16211609	0	copper	57,63	ATP7B	21,26	copper	ATP7B	MESH:D003300	540	Chemical	Gene	metabolism|compound|START_ENTITY mutation|nmod|metabolism mutation|nmod|parameters parameters|compound|END_ENTITY	p.H1069Q mutation in ATP7B and biochemical parameters of copper metabolism and clinical manifestation of Wilson 's _ disease .
16472602	0	copper	42,48	ATP7B	0,5	copper	ATP7B	MESH:D003300	100770719	Chemical	Gene	sequestration|nmod|START_ENTITY sequestration|nummod|END_ENTITY	ATP7B mediates vesicular sequestration of copper : insight into biliary_copper_excretion .
17680703	0	copper	51,57	ATP7B	71,76	copper	ATP7B	MESH:D003300	540	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Sequence variation database for the Wilson_disease copper transporter , ATP7B .
18203200	0	copper	95,101	ATP7B	80,85	copper	ATP7B	MESH:D003300	540	Chemical	Gene	transport|compound|START_ENTITY affects|dobj|transport affects|nsubj|variation variation|appos|END_ENTITY	Sequence variation in the ATP-binding domain of the Wilson_disease transporter , ATP7B , affects copper transport in a yeast model system .
19007772	0	copper	35,41	ATP7B	97,102	copper	ATP7B	MESH:D003300	540	Chemical	Gene	transports|dobj|START_ENTITY transports|advcl|resides resides|nsubj|END_ENTITY	Niemann-Pick_C1 protein transports copper to the secretory compartment from late endosomes where ATP7B resides .
19416479	0	copper	83,89	ATP7B	56,61	copper	ATP7B	MESH:D003300	540	Chemical	Gene	storage|compound|START_ENTITY END_ENTITY|nmod|storage	Cell-specific trafficking suggests a new role for renal ATP7B in the intracellular copper storage .
20333758	0	copper	71,77	ATP7B	91,96	copper	ATP7B	MESH:D003300	540	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Functional analysis of mutations in the ATP loop of the Wilson_disease copper transporter , ATP7B .
21189263	0	copper	72,78	ATP7B	65,70	copper	ATP7B	MESH:D003300	540	Chemical	Gene	ATPase|compound|START_ENTITY END_ENTITY|appos|ATPase	Involvement of protein_kinase_D in expression and trafficking of ATP7B -LRB- copper ATPase -RRB- .
22692182	0	copper	26,32	ATP7B	40,45	copper	ATP7B	MESH:D003300	540	Chemical	Gene	ATPase|compound|START_ENTITY model|nmod|ATPase END_ENTITY|nsubj|model	A structural model of the copper ATPase ATP7B to facilitate analysis of Wilson_disease-causing mutations and studies of the transport mechanism .
26032686	0	copper	56,62	ATP7B	19,24	copper	ATP7B	MESH:D003300	540	Chemical	Gene	tolerance|compound|START_ENTITY mutations|nmod|tolerance missense|dobj|mutations missense|nsubj|roles roles|nmod|END_ENTITY	Defective roles of ATP7B missense mutations in cellular copper tolerance and copper_excretion .
26797276	2	copper	170,176	ATP7B	217,222	copper	Atox1	MESH:D003300	475	Chemical	Gene	transport|compound|START_ENTITY receives|nmod|transport receives|nsubj|END_ENTITY	For copper ion transport , the multi-domain protein ATP7B in the Golgi network receives copper from the cytoplasmic copper chaperone Atox1 and , with energy from ATP hydrolysis , moves the metal to the lumen for loading of copper-dependent enzymes .
26797276	2	copper	253,259	ATP7B	217,222	copper	Atox1	MESH:D003300	475	Chemical	Gene	receives|dobj|START_ENTITY receives|nsubj|END_ENTITY	For copper ion transport , the multi-domain protein ATP7B in the Golgi network receives copper from the cytoplasmic copper chaperone Atox1 and , with energy from ATP hydrolysis , moves the metal to the lumen for loading of copper-dependent enzymes .
26797276	2	copper	281,287	ATP7B	217,222	copper	Atox1	MESH:D003300	475	Chemical	Gene	Atox1|compound|START_ENTITY receives|nmod|Atox1 receives|nsubj|END_ENTITY	For copper ion transport , the multi-domain protein ATP7B in the Golgi network receives copper from the cytoplasmic copper chaperone Atox1 and , with energy from ATP hydrolysis , moves the metal to the lumen for loading of copper-dependent enzymes .
25122912	0	copper	75,81	Amyloid_precursor_protein	0,25	copper	Amyloid precursor protein	MESH:D003300	351	Chemical	Gene	depend|nmod|START_ENTITY depend|nsubj|dimerization dimerization|compound|END_ENTITY	Amyloid_precursor_protein dimerization and synaptogenic function depend on copper binding to the growth_factor-like_domain .
17608643	0	copper	41,47	Ancient_conserved_domain_protein-1	0,34	copper	Ancient conserved domain protein-1	MESH:D003300	26507	Chemical	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Ancient_conserved_domain_protein-1 binds copper and modifies its retention in cells .
11391006	0	copper	62,68	Atox1	21,26	copper	Atox1	MESH:D003300	11927(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY role|nmod|homeostasis plays|dobj|role plays|nsubj|END_ENTITY	The metallochaperone Atox1 plays a critical role in perinatal copper homeostasis .
18685091	0	copper	28,34	Atox1	69,74	copper	Atox1	MESH:D003300	475	Chemical	Gene	release|compound|START_ENTITY release|nmod|END_ENTITY	Conserved residues modulate copper release in human copper chaperone Atox1 .
21327972	0	copper	32,38	Atp7b	57,62	copper	Atp7b	MESH:D003300	11979(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY tomography|nmod|metabolism tomography|nmod|END_ENTITY	Positron emission tomography of copper metabolism in the Atp7b - / - knock-out mouse model of Wilson 's _ disease .
21645498	0	copper	46,52	Atp7b	65,70	copper	Atp7b	MESH:D003300	11979(Tax:10090)	Chemical	Gene	ions|compound|START_ENTITY Fragmentation|nmod|ions Fragmentation|nmod|END_ENTITY	Fragmentation of mitochondrial cardiolipin by copper ions in the Atp7b - / - mouse model of Wilson 's _ disease .
22170165	0	copper	8,14	Atp7b	39,44	copper	Atp7b	MESH:D003300	11979(Tax:10090)	Chemical	Gene	imbalance|compound|START_ENTITY imbalance|nmod|END_ENTITY	Imaging copper metabolism imbalance in Atp7b -LRB- - / - -RRB- knockout mouse model of Wilson 's _ disease with PET-CT and orally administered 64CuCl2 .
14726516	0	copper	16,22	COPT1	35,40	copper	COPT1	MESH:D003300	836020(Tax:3702)	Chemical	Gene	transporter|nsubj|START_ENTITY transporter|dobj|functions functions|nummod|END_ENTITY	The Arabidopsis copper transporter COPT1 functions in root elongation and pollen development .
21131558	0	copper	21,27	CRR1	4,8	copper	CRR1	MESH:D003300	5720626(Tax:3055)	Chemical	Gene	sensor|compound|START_ENTITY sensor|compound|END_ENTITY	The CRR1 nutritional copper sensor in Chlamydomonas contains two distinct metal-responsive domains .
12777486	0	copper	52,58	CTR1	21,25	copper	CTR1	MESH:D003300	856241(Tax:4932)	Chemical	Gene	transporter|compound|START_ENTITY encodes|dobj|transporter encodes|nsubj|gene gene|compound|END_ENTITY	The Candida_albicans CTR1 gene encodes a functional copper transporter .
16135512	0	copper	17,23	CTR1	49,53	copper	CTR1	MESH:D003300	1317	Chemical	Gene	uptake|compound|START_ENTITY mechanism|nmod|uptake mediated|nsubj|mechanism mediated|nmod|END_ENTITY	The mechanism of copper uptake mediated by human CTR1 : a mutational analysis .
16847145	0	copper	26,32	CTR1	52,56	copper	CTR1	MESH:D003300	20529(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY Contribution|nmod|transporter END_ENTITY|nsubj|Contribution	Contribution of the major copper influx transporter CTR1 to the cellular accumulation of cisplatin , carboplatin , and oxaliplatin .
20631178	0	copper	12,18	CTR1	32,36	copper	CTR1	MESH:D003300	20529(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Role of the copper transporter , CTR1 , in platinum-induced ototoxicity .
21570711	0	copper	24,30	CTR1	45,49	copper	CTR1	MESH:D003300	1317	Chemical	Gene	transporters|compound|START_ENTITY value|nmod|transporters value|appos|END_ENTITY	Prognostic value of the copper transporters , CTR1 and CTR2 , in patients with ovarian_carcinoma receiving platinum-based chemotherapy .
22354499	0	copper	10,16	CTR1	67,71	copper	CTR1	MESH:D003300	799	Chemical	Gene	Uptake|nmod|START_ENTITY Uptake|nmod|cells cells|acl:relcl|modulated modulated|nsubjpass|expression expression|nmod|END_ENTITY	Uptake of copper from plasma proteins in cells where expression of CTR1 has been modulated .
22465424	0	copper	42,48	CTR1	25,29	copper	CTR1	MESH:D003300	1317	Chemical	Gene	transport|compound|START_ENTITY contribution|nmod|transport contribution|nmod|END_ENTITY	Relative contribution of CTR1 and DMT1 in copper transport by the blood-CSF barrier : implication in manganese-induced neurotoxicity .
22670529	0	copper	120,126	CTR1	79,83	copper	CTR1	MESH:D003300	20529(Tax:10090)	Chemical	Gene	-RSB-|compound|START_ENTITY transport|dobj|-RSB- ability|acl|transport determines|dobj|ability determines|nsubj|organization organization|nmod|END_ENTITY	-LSB- Structure-functional organization of eukaryotic high-affinity copper importer CTR1 determines its ability to transport copper , silver and cisplatin -RSB- .
23391749	0	copper	14,20	CTR1	34,38	copper	CTR1	MESH:D003300	1317	Chemical	Gene	transporters|nsubj|START_ENTITY transporters|dobj|END_ENTITY	The mammalian copper transporters CTR1 and CTR2 and their roles in development and disease .
24039729	0	copper	49,55	CTR1	0,4	copper	CTR1	MESH:D003300	1317	Chemical	Gene	entry|compound|START_ENTITY limiting|dobj|entry inhibits|advcl|limiting inhibits|nsubj|silencing silencing|compound|END_ENTITY	CTR1 silencing inhibits angiogenesis by limiting copper entry into endothelial cells .
24316150	0	copper	51,57	CTR1	15,19	copper	CTR1	MESH:D003300	1317	Chemical	Gene	Involvement|dep|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of CTR1 and ATP7A in lead -LRB- Pb -RRB- - induced copper _ -LRB- Cu -RRB- _ accumulation in choroidal epithelial cells .
24485600	0	copper	51,57	CTR1	46,50	copper	CTR1	MESH:D003300	1317	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Copper and lactational hormones influence the CTR1 copper transporter in PMC42-LA mammary epithelial cell culture models .
24485600	10	copper	1724,1730	CTR1	1716,1720	copper	CTR1	MESH:D003300	1317	Chemical	Gene	uptake|compound|START_ENTITY showing|nmod|uptake showing|dobj|function function|nmod|END_ENTITY	Based on previous data showing a function for CTR1 in copper uptake , we have concluded that under the influence of hormones and increased extracellular copper levels , CTR1 participates in uptake of copper by mammary epithelial cells , as a prerequisite for secretion of copper into milk .
24485600	10	copper	1868,1874	CTR1	1716,1720	copper	CTR1	MESH:D003300	1317	Chemical	Gene	uptake|nmod|START_ENTITY participates|nmod|uptake concluded|ccomp|participates concluded|advcl|data data|acl|showing showing|dobj|function function|nmod|END_ENTITY	Based on previous data showing a function for CTR1 in copper uptake , we have concluded that under the influence of hormones and increased extracellular copper levels , CTR1 participates in uptake of copper by mammary epithelial cells , as a prerequisite for secretion of copper into milk .
24485600	10	copper	1939,1945	CTR1	1716,1720	copper	CTR1	MESH:D003300	1317	Chemical	Gene	secretion|nmod|START_ENTITY prerequisite|nmod|secretion participates|nmod|prerequisite concluded|ccomp|participates concluded|advcl|data data|acl|showing showing|dobj|function function|nmod|END_ENTITY	Based on previous data showing a function for CTR1 in copper uptake , we have concluded that under the influence of hormones and increased extracellular copper levels , CTR1 participates in uptake of copper by mammary epithelial cells , as a prerequisite for secretion of copper into milk .
24800945	0	copper	73,79	CTR1	101,105	copper	CTR1	MESH:D003300	397186(Tax:9823)	Chemical	Gene	SLC31A1|compound|START_ENTITY kill|parataxis|SLC31A1 compounds|acl:relcl|kill compounds|appos|END_ENTITY	Uptake of compounds that selectively kill multidrug-resistant cells : the copper transporter SLC31A1 -LRB- CTR1 -RRB- increases cellular accumulation of the thiosemicarbazone_NSC73306 .
24837030	0	copper	48,54	CTR1	113,117	copper	CTR1	MESH:D003300	1317	Chemical	Gene	flexibility|nmod|START_ENTITY Probing|dobj|flexibility metallochaperone|csubj|Probing metallochaperone|nmod|domain domain|compound|END_ENTITY	Probing the structural flexibility of the human copper metallochaperone Atox1 dimer and its interaction with the CTR1 c-terminal domain .
24967972	0	copper	28,34	CTR1	71,75	copper	CTR1	MESH:D003300	1317	Chemical	Gene	transport|compound|START_ENTITY modulation|nmod|transport function|nsubj|modulation function|nmod|END_ENTITY	Molecular modulation of the copper and cisplatin transport function of CTR1 and its interaction with IRS-4 .
25594011	0	copper	51,57	CTR1	123,127	copper	CTR1	MESH:D003300	1317	Chemical	Gene	pharmacology|nmod|START_ENTITY modulates|dobj|pharmacology modulates|advcl|regulating regulating|dobj|expression expression|nmod|END_ENTITY	Integrin aV modulates the cellular pharmacology of copper and cisplatin by regulating expression of the influx transporter CTR1 .
12795705	0	copper	71,77	CUTA	25,29	copper	CUTA	MESH:D003300	817940(Tax:3702)	Chemical	Gene	protein|compound|START_ENTITY encodes|dobj|protein encodes|nsubj|gene gene|compound|END_ENTITY	The Arabidopsis_thaliana CUTA gene encodes an evolutionarily conserved copper binding chloroplast protein .
25557959	0	copper	12,18	CUTA	50,54	copper	CUTA	MESH:D003300	67675(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY END_ENTITY|nsubj|role	The role of copper and the copper-related protein CUTA in mediating APP processing and Ab generation .
10764731	0	copper	89,95	Ccc2	109,113	copper	Ccc2	MESH:D003300	851862(Tax:4932)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Energetics of copper trafficking between the Atx1 metallochaperone and the intracellular copper transporter , Ccc2 .
16365053	0	copper	84,90	Copper_transport_protein	0,24	copper	Copper transport protein	MESH:D003300	20529(Tax:10090)	Chemical	Gene	status|compound|START_ENTITY tissue|nmod|status tissue|nsubj|levels levels|amod|END_ENTITY	Copper_transport_protein -LRB- Ctr1 -RRB- levels in mice are tissue specific and dependent on copper status .
24522273	0	copper	45,51	Copper_transporter_2	0,20	copper	Copper transporter 2	MESH:D003300	1318	Chemical	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Copper_transporter_2 regulates intracellular copper and sensitivity to cisplatin .
12788943	0	copper	50,56	Cox17p	40,46	copper	Cox17p	MESH:D003300	10063	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|nmod|transport	Mutagenesis reveals a specific role for Cox17p in copper transport to cytochrome oxidase .
9407107	0	copper	82,88	Cox17p	58,64	copper	Cox17p	MESH:D003300	850651(Tax:4932)	Chemical	Gene	shuttle|compound|START_ENTITY END_ENTITY|appos|shuttle	Purification , characterization , and localization of yeast Cox17p , a mitochondrial copper shuttle .
11391005	0	copper	56,62	Ctr1	48,52	copper	Ctr1	MESH:D003300	1317	Chemical	Gene	homeostasis|compound|START_ENTITY role|nmod|homeostasis role|nmod|END_ENTITY	Essential role for mammalian copper transporter Ctr1 in copper homeostasis and embryonic development .
11734551	0	copper	42,48	Ctr1	61,65	copper	Ctr1	MESH:D003300	1317	Chemical	Gene	transporter|compound|START_ENTITY characterization|nmod|transporter END_ENTITY|nsubj|characterization	Biochemical characterization of the human copper transporter Ctr1 .
12120136	0	copper	36,42	Ctr1	48,52	copper	Ctr1	MESH:D003300	856241(Tax:4932)	Chemical	Gene	domain|nmod|START_ENTITY pump|nsubj|domain pump|dobj|copper copper|amod|END_ENTITY	A C-terminal domain of the membrane copper pump Ctr1 exchanges copper -LRB- I -RRB- with the copper chaperone Atx1 .
12120136	0	copper	82,88	Ctr1	48,52	copper	Ctr1	MESH:D003300	856241(Tax:4932)	Chemical	Gene	Atx1|compound|START_ENTITY copper|nmod|Atx1 copper|amod|END_ENTITY	A C-terminal domain of the membrane copper pump Ctr1 exchanges copper -LRB- I -RRB- with the copper chaperone Atx1 .
14976198	0	copper	105,111	Ctr1	100,104	copper	Ctr1	MESH:D003300	1317	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	Identification of methionine-rich clusters that regulate copper-stimulated endocytosis of the human Ctr1 copper transporter .
15012137	0	copper	213,219	Ctr1	53,57	copper	Ctr1	MESH:D003300	856241(Tax:4932)	Chemical	Gene	trafficking|compound|START_ENTITY involved|nmod|trafficking proteins|acl|involved affinity|nmod|proteins cluster|dep|affinity ions|nmod|cluster binds|ccomp|ions binds|nsubj|domain domain|nmod|END_ENTITY	C-terminal domain of the membrane copper transporter Ctr1 from Saccharomyces_cerevisiae binds four Cu -LRB- I -RRB- ions as a cuprous-thiolate polynuclear cluster : sub-femtomolar Cu -LRB- I -RRB- affinity of three proteins involved in copper trafficking .
15326162	0	copper	60,66	Ctr1	55,59	copper	Ctr1	MESH:D003300	1317	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	Cisplatin stabilizes a multimeric complex of the human Ctr1 copper transporter : requirement for the extracellular methionine-rich clusters .
16365053	0	copper	84,90	Ctr1	26,30	copper	Ctr1	MESH:D003300	20529(Tax:10090)	Chemical	Gene	status|compound|START_ENTITY tissue|nmod|status tissue|nsubj|levels levels|amod|END_ENTITY	Copper_transport_protein -LRB- Ctr1 -RRB- levels in mice are tissue specific and dependent on copper status .
16741141	0	copper	14,20	Ctr1	81,85	copper	Ctr1	MESH:D003300	171135(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY stimulated|nsubjpass|transport stimulated|nmod|alterations alterations|nmod|END_ENTITY	Mammary gland copper transport is stimulated by prolactin through alterations in Ctr1 and Atp7A localization .
16950140	0	copper	23,29	Ctr1	0,4	copper	Ctr1	MESH:D003300	20529(Tax:10090)	Chemical	Gene	absorption|compound|START_ENTITY drives|dobj|absorption drives|nsubj|END_ENTITY	Ctr1 drives intestinal copper absorption and is essential for growth , iron metabolism , and neonatal cardiac function .
19088072	0	copper	99,105	Ctr1	35,39	copper	Ctr1	MESH:D003300	856241(Tax:4932)	Chemical	Gene	down-regulated|nmod|START_ENTITY down-regulated|nsubjpass|activity activity|nmod|END_ENTITY	Copper transport activity of yeast Ctr1 is down-regulated via its C terminus in response to excess copper .
19095764	0	copper	100,106	Ctr1	20,24	copper	Ctr1	MESH:D003300	20529(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY reveals|nmod|homeostasis reveals|nsubj|Deletion Deletion|nmod|END_ENTITY	Deletion of hepatic Ctr1 reveals its function in copper acquisition and compensatory mechanisms for copper homeostasis .
19095764	0	copper	49,55	Ctr1	20,24	copper	Ctr1	MESH:D003300	20529(Tax:10090)	Chemical	Gene	acquisition|compound|START_ENTITY function|nmod|acquisition reveals|dobj|function reveals|nsubj|Deletion Deletion|nmod|END_ENTITY	Deletion of hepatic Ctr1 reveals its function in copper acquisition and compensatory mechanisms for copper homeostasis .
20699218	0	copper	18,24	Ctr1	0,4	copper	Ctr1	MESH:D003300	1317	Chemical	Gene	transporter|compound|START_ENTITY transporter|nsubj|END_ENTITY	Ctr1 is an apical copper transporter in mammalian intestinal epithelial cells in vivo that is controlled at the level of protein stability .
21375246	0	copper	111,117	Ctr1	134,138	copper	Ctr1	MESH:D003300	1317	Chemical	Gene	acquisition|compound|START_ENTITY acquisition|nmod|END_ENTITY	Model peptides provide new insights into the role of histidine residues as potential ligands in human cellular copper acquisition via Ctr1 .
23123662	0	copper	56,62	Ctr1	21,25	copper	Ctr1	MESH:D003300	171135(Tax:10116)	Chemical	Gene	uptake|nmod|START_ENTITY END_ENTITY|nmod|uptake	Contributions of rat Ctr1 to the uptake and toxicity of copper and platinum anticancer drugs in dorsal root ganglion neurons .
23879689	0	copper	15,21	Ctr1	34,38	copper	Ctr1	MESH:D003300	1317	Chemical	Gene	transporter|compound|START_ENTITY role|nmod|transporter END_ENTITY|nsubj|role	A role for the copper transporter Ctr1 in the synergistic interaction between hyperthermia and cisplatin treatment .
24167251	0	copper	92,98	Ctr1	57,61	copper	Ctr1	MESH:D003300	1317	Chemical	Gene	lacking|dobj|START_ENTITY transporter|acl|lacking transporter|amod|END_ENTITY	Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal transporter lacking the copper - and cisplatin-binding ecto-domain .
24697869	0	copper	4,10	Ctr1	84,88	copper	Ctr1	MESH:D003300	1317	Chemical	Gene	traverses|nsubj|START_ENTITY END_ENTITY|dep|traverses	How copper traverses cellular membranes through the mammalian copper_transporter_1 , Ctr1 .
24703712	0	copper	39,45	Ctr1	12,16	copper	Ctr1	MESH:D003300	799	Chemical	Gene	homeostasis|compound|START_ENTITY role|nmod|homeostasis role|nmod|END_ENTITY	The role of Ctr1 and Ctr2 in mammalian copper homeostasis and platinum-based chemotherapy .
17645432	0	copper	81,87	Ctr1p	101,106	copper	Ctr1p	MESH:D003300	856241(Tax:4932)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Regulation of copper-dependent endocytosis and vacuolar degradation of the yeast copper transporter , Ctr1p , by the Rsp5 ubiquitin ligase .
22304436	0	copper	14,20	Ctr1p	68,73	copper	Ctr1p	MESH:D003300	856241(Tax:4932)	Chemical	Gene	uptake|compound|START_ENTITY Inhibition|nmod|uptake reveals|nsubj|Inhibition reveals|dobj|END_ENTITY	Inhibition of copper uptake in yeast reveals the copper transporter Ctr1p as a potential molecular target of saxitoxin .
7929270	0	copper	29,35	Ctr1p	55,60	copper	Ctr1p	MESH:D003300	856241(Tax:4932)	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	The Saccharomyces_cerevisiae copper transport protein -LRB- Ctr1p -RRB- .
20824073	0	copper	11,17	Ctr2	0,4	copper	Ctr2	MESH:D003300	1318	Chemical	Gene	homeostasis|compound|START_ENTITY links|dobj|homeostasis links|nsubj|END_ENTITY	Ctr2 links copper homeostasis to polysaccharide capsule formation and phagocytosis inhibition in the human fungal pathogen Cryptococcus_neoformans .
24167251	0	copper	92,98	Ctr2	0,4	copper	Ctr2	MESH:D003300	1318	Chemical	Gene	lacking|dobj|START_ENTITY transporter|acl|lacking form|nmod|transporter biogenesis|nmod|form regulates|dobj|biogenesis regulates|nsubj|END_ENTITY	Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal transporter lacking the copper - and cisplatin-binding ecto-domain .
10924521	0	copper	63,69	Ctr3	82,86	copper	Ctr3	MESH:D003300	851129(Tax:4932)	Chemical	Gene	transporter|compound|START_ENTITY Characterization|nmod|transporter END_ENTITY|nsubj|Characterization	Characterization of the Saccharomyces_cerevisiae high affinity copper transporter Ctr3 .
20202748	0	copper	7,13	CuZn-superoxide_dismutase	127,152	copper	CuZn-superoxide dismutase	MESH:D003300	6647	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Excess copper induces production of hydrogen_peroxide in the leaf of Elsholtzia haichowensis through apoplastic and symplastic CuZn-superoxide_dismutase .
24089420	0	copper	45,51	Divalent_metal_transporter_1	0,28	copper	Divalent metal transporter 1	MESH:D003300	24906(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY mediates|dobj|transport mediates|nsubj|END_ENTITY	Divalent_metal_transporter_1 -LRB- Dmt1 -RRB- mediates copper transport in the duodenum of iron-deficient rats and when overexpressed in iron-deprived HEK-293 cells .
18321764	0	copper	45,51	DmATP7	64,70	copper	DmATP7	MESH:D003300	32142(Tax:7227)	Chemical	Gene	Expression|nmod|START_ENTITY transporter|nsubj|Expression transporter|dobj|END_ENTITY	Expression and localisation of the essential copper transporter DmATP7 in Drosophila neuronal and intestinal tissues .
20038716	0	copper	66,72	DmATP7	56,62	copper	DmATP7	MESH:D003300	32142(Tax:7227)	Chemical	Gene	absorption|compound|START_ENTITY END_ENTITY|nmod|absorption	A Drosophila model of Menkes_disease reveals a role for DmATP7 in copper absorption and neurodevelopment .
12482851	0	copper	34,40	Doppel	21,27	copper	Doppel	MESH:D003300	26434(Tax:10090)	Chemical	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	The PrP-like protein Doppel binds copper .
15133031	0	copper	44,50	FKBP52	34,40	copper	FKBP52	MESH:D003300	2288	Chemical	Gene	transport|compound|START_ENTITY role|nmod|transport role|nmod|END_ENTITY	A novel role for the immunophilin FKBP52 in copper transport .
11389633	0	copper	42,48	Fet3p	57,62	copper	Fet3p	MESH:D003300	855080(Tax:4932)	Chemical	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Spectroscopy and reactivity of the type 1 copper site in Fet3p from Saccharomyces_cerevisiae : correlation of structure with reactivity in the multicopper oxidases .
10557326	0	copper	90,96	HAH1	36,40	copper	HAH1	MESH:D003300	475	Chemical	Gene	homeostasis|compound|START_ENTITY essential|nmod|homeostasis essential|nsubj|Interaction Interaction|nmod|END_ENTITY	Interaction of the copper chaperone HAH1 with the Wilson_disease protein is essential for copper homeostasis .
16172131	0	copper	73,79	HAH1	97,101	copper	HAH1	MESH:D003300	475	Chemical	Gene	study|nmod|START_ENTITY study|dep|END_ENTITY	A NMR study of the interaction of a three-domain construct of ATP7A with copper -LRB- I -RRB- and copper -LRB- I -RRB- - HAH1 : the interplay of domains .
16571664	0	copper	117,123	HAH1	109,113	copper	HAH1	MESH:D003300	475	Chemical	Gene	uptake|compound|START_ENTITY END_ENTITY|nmod|uptake	Structure of human Wilson protein domains 5 and 6 and their interplay with domain 4 and the copper chaperone HAH1 in copper uptake .
23677531	0	copper	50,56	HAH1	67,71	copper	HAH1	MESH:D003300	475	Chemical	Gene	chaperone|compound|START_ENTITY environment|nmod|chaperone Probing|dobj|environment bridged|dep|Probing bridged|nsubj|END_ENTITY	Probing the coordination environment of the human copper chaperone HAH1 : characterization of Hg -LRB- II -RRB- - bridged homodimeric species in solution .
9083055	0	copper	81,87	HAH1	44,48	copper	HAH1	MESH:D003300	475	Chemical	Gene	homeostasis|compound|START_ENTITY involved|nmod|homeostasis involved|nsubj|expression expression|nmod|END_ENTITY	Identification and functional expression of HAH1 , a novel human gene involved in copper homeostasis .
9430722	0	copper	77,83	HAH1	0,4	copper	HAH1	MESH:D003300	475	Chemical	Gene	homeostasis|compound|START_ENTITY mediating|dobj|homeostasis residues|acl|mediating protein|nmod|residues protein|nsubj|END_ENTITY	HAH1 is a copper-binding protein with distinct amino_acid residues mediating copper homeostasis and antioxidant defense .
22367704	0	copper	10,16	IGF-1	38,43	copper	IGF-1	MESH:D003300	101055342	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	Effect of copper on the expression of IGF-1 from chondrocytes in newborn piglets in vitro .
24967972	0	copper	28,34	IRS-4	101,106	copper	IRS-4	MESH:D003300	8471	Chemical	Gene	transport|compound|START_ENTITY modulation|nmod|transport function|nsubj|modulation function|nmod|END_ENTITY	Molecular modulation of the copper and cisplatin transport function of CTR1 and its interaction with IRS-4 .
25187679	0	copper	60,66	Lysyl_Oxidase	27,40	copper	Lysyl Oxidase	MESH:D003300	4015	Chemical	Gene	orientation|compound|START_ENTITY model|nmod|orientation model|nmod|END_ENTITY	A molecular model of human Lysyl_Oxidase -LRB- LOX -RRB- with optimal copper orientation in the catalytic cavity for induced fit docking studies with potential modulators .
10332039	0	copper	39,45	Mnk	64,67	copper	Mnk	MESH:D003300	11977(Tax:10090)	Chemical	Gene	responsiveness|compound|START_ENTITY responsiveness|nmod|END_ENTITY	Intracellular localization and loss of copper responsiveness of Mnk , the murine homologue of the Menkes protein , in cells from blotchy -LRB- Mo blo -RRB- and brindled -LRB- Mo br -RRB- mouse mutants .
11841570	0	copper	86,92	P2X4	96,100	copper	P2X4	MESH:D003300	29659(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|receptors receptors|compound|END_ENTITY	Formation of carnosine-Cu -LRB- II -RRB- complexes prevents and reverts the inhibitory action of copper in P2X4 and P2X7 receptors .
10561700	0	copper	81,87	Prion_protein	0,13	copper	Prion protein	MESH:D003300	5621	Chemical	Gene	uptake|nmod|START_ENTITY aids|dobj|uptake aids|nsubj|expression expression|compound|END_ENTITY	Prion_protein expression aids cellular uptake and veratridine-induced release of copper .
11278306	0	copper	20,26	Prion_protein	0,13	copper	Prion protein	MESH:D003300	5621	Chemical	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Prion_protein binds copper within the physiological concentration range .
14511115	0	copper	44,50	Prion_protein	0,13	copper	Prion protein	MESH:D003300	19122(Tax:10090)	Chemical	Gene	content|compound|START_ENTITY modulates|dobj|content modulates|nsubj|expression expression|compound|END_ENTITY	Prion_protein expression modulates neuronal copper content .
21264406	0	copper	47,53	Prion_protein	0,13	copper	Prion protein	MESH:D003300	19122(Tax:10090)	Chemical	Gene	content|compound|START_ENTITY alters|dobj|content alters|nsubj|level level|compound|END_ENTITY	Prion_protein expression level alters regional copper , iron and zinc content in the mouse brain .
7657650	0	copper	34,40	S-adenosylhomocysteine_hydrolase	60,92	copper	S-adenosylhomocysteine hydrolase	MESH:D003300	191	Chemical	Gene	protein|compound|START_ENTITY protein|nmod|END_ENTITY	Identification of a major hepatic copper binding protein as S-adenosylhomocysteine_hydrolase .
7657650	8	copper	1073,1079	SAHH	1100,1104	copper	SAHH	MESH:D003300	191	Chemical	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	The copper binding activity of SAHH is proposed to play a significant role in the intracellular distribution of copper , and SAHH enzymatic activity may influence copper metabolism through its role in cysteine biosynthesis from methionine .
21188142	0	copper	27,33	Syntaxin_5	0,10	copper	Syntaxin 5	MESH:D003300	34966(Tax:7227)	Chemical	Gene	homeostasis|compound|START_ENTITY required|nmod|homeostasis required|nsubjpass|END_ENTITY	Syntaxin_5 is required for copper homeostasis in Drosophila and mammals .
16543147	0	copper	10,16	XIAP	0,4	copper	XIAP	MESH:D003300	331	Chemical	Gene	protein|compound|START_ENTITY protein|nsubj|END_ENTITY	XIAP Is a copper binding protein deregulated in Wilson 's _ disease and other copper_toxicosis disorders .
12732458	0	copper	94,100	acetylcholinesterase	10,30	copper	acetylcholinesterase	MESH:D003300	43	Chemical	Gene	concentrations|compound|START_ENTITY exposed|nmod|concentrations exposed|nsubj|activities activities|compound|END_ENTITY	Increased acetylcholinesterase activities in specimens of Sparus auratus exposed to sublethal copper concentrations .
23354609	0	copper	22,28	acetylcholinesterase	58,78	copper	acetylcholinesterase	MESH:D003300	83817(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|contents contents|amod|END_ENTITY	Protective effects of copper against aluminum toxicity on acetylcholinesterase and catecholamine contents of different regions of rat 's brain .
17239395	0	copper	106,112	amyloid_precursor_protein	38,63	copper	amyloid precursor protein	MESH:D003300	351	Chemical	Gene	ions|compound|START_ENTITY binds|dobj|ions reveal|ccomp|binds reveal|nsubj|studies studies|nmod|domain domain|amod|END_ENTITY	Structural studies of the Alzheimer 's amyloid_precursor_protein copper-binding domain reveal how it binds copper ions .
21648462	0	copper	55,61	amyloid_precursor_protein	80,105	copper	amyloid precursor protein	MESH:D003300	351	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|APP APP|compound|END_ENTITY	Effects of Cu ions and explicit water molecules on the copper binding domain of amyloid_precursor_protein APP -LRB- 131-189 -RRB- : a molecular dynamics study .
25305487	0	copper	7,13	amyloid_precursor_protein	44,69	copper	amyloid precursor protein	MESH:D003300	351	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	The E1 copper binding domain of full-length amyloid_precursor_protein mitigates copper-induced growth inhibition in brain metastatic prostate_cancer DU145 cells .
12127064	0	copper	46,52	apolipoprotein_B	121,137	copper	apolipoprotein B	MESH:D003300	338	Chemical	Gene	oxidation|nmod|START_ENTITY features|nmod|oxidation features|nmod|END_ENTITY	In vitro low-density lipoprotein oxidation by copper or * OH/O * -LRB- 2 -RRB- -LRB- - -RRB- : new features on carbonylation and fragmentation of apolipoprotein_B during the lag phase .
1381932	0	copper	22,28	apolipoprotein_B	43,59	copper	apolipoprotein B	MESH:D003300	54225(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of dietary copper on rat plasma apolipoprotein_B , E plasma levels , and apolipoprotein gene expression in liver and intestine .
14767076	0	copper	108,114	beta_2-microglobulin	46,66	copper	beta 2-microglobulin	MESH:D003300	567	Chemical	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Increase in the conformational flexibility of beta_2-microglobulin upon copper binding : a possible role for copper in dialysis-related amyloidosis .
21551946	0	copper	77,83	carbonic_anhydrase_III	51,73	copper	carbonic anhydrase III	MESH:D003300	54232(Tax:10116)	Chemical	Gene	accumulation|compound|START_ENTITY END_ENTITY|nmod|accumulation	Sexual dimorphism in LEC rat liver : suppression of carbonic_anhydrase_III by copper accumulation during hepatocarcinogenesis .
4965681	0	copper	106,112	carbonic_anhydrases_B_and_C	16,43	copper	carbonic anhydrases B and C	MESH:D003300	760	Chemical	Gene	activity|nmod|START_ENTITY activity|nmod|END_ENTITY	The activity of carbonic_anhydrases_B_and_C from human erythrocytes and the inhibition of the enzymes fby copper .
20194531	0	copper	49,55	copper_transporter_2	14,34	copper	copper transporter 2	MESH:D003300	1318	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of copper_transporter_2 expression by copper and cisplatin in human ovarian_carcinoma cells .
12177073	0	copper	78,84	ctr1	59,63	copper	ctr1	MESH:D003300	20529(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	Characterization of mouse embryonic_cells_deficient in the ctr1 high affinity copper transporter .
15019990	0	copper	66,72	ctr1	88,92	copper	ctr1	MESH:D003300	403028(Tax:7955)	Chemical	Gene	pattern|nmod|START_ENTITY transporter|nsubj|pattern transporter|dobj|gene gene|compound|END_ENTITY	Cloning , expression pattern and essentiality of the high-affinity copper transporter 1 -LRB- ctr1 -RRB- gene in zebrafish .
16133162	0	copper	96,102	ctr1	50,54	copper	ctr1	MESH:D003300	856241(Tax:4932)	Chemical	Gene	transporter|compound|START_ENTITY coding|nmod|transporter gene|acl|coding characterisation|appos|gene characterisation|nmod|END_ENTITY	Identification and functional characterisation of ctr1 , a Pleurotus_ostreatus gene coding for a copper transporter .
23576094	0	copper	147,153	ctr1	18,22	copper	ctr1	MESH:D003300	856241(Tax:4932)	Chemical	Gene	Saccharomyces_cerevisiae|nmod|START_ENTITY C-terminus|nmod|Saccharomyces_cerevisiae deletion|nmod|C-terminus transporter|nmod|deletion \|appos|transporter leads|nsubj|\ Overexpression|parataxis|leads Overexpression|nmod|END_ENTITY	Overexpression of ctr1 / \ 300 , a high-affinity copper transporter with deletion of the cytosolic C-terminus in Saccharomyces_cerevisiae under excess copper , leads to disruption of transition_metal homeostasis and transcriptional remodelling of cellular processes .
23576094	0	copper	45,51	ctr1	18,22	copper	ctr1	MESH:D003300	856241(Tax:4932)	Chemical	Gene	transporter|compound|START_ENTITY \|appos|transporter leads|nsubj|\ Overexpression|parataxis|leads Overexpression|nmod|END_ENTITY	Overexpression of ctr1 / \ 300 , a high-affinity copper transporter with deletion of the cytosolic C-terminus in Saccharomyces_cerevisiae under excess copper , leads to disruption of transition_metal homeostasis and transcriptional remodelling of cellular processes .
15494390	0	copper	30,36	ctr2	51,55	copper	ctr2	MESH:D003300	856580(Tax:4932)	Chemical	Gene	Mobilization|nmod|START_ENTITY stores|nsubj|Mobilization stores|nmod|transporter transporter|amod|END_ENTITY	Mobilization of intracellular copper stores by the ctr2 vacuolar copper transporter .
15494390	0	copper	65,71	ctr2	51,55	copper	ctr2	MESH:D003300	856580(Tax:4932)	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	Mobilization of intracellular copper stores by the ctr2 vacuolar copper transporter .
15777277	0	copper	21,27	cystathionine_beta-synthase	31,58	copper	cystathionine beta-synthase	MESH:D003300	875	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Inhibitory effect of copper on cystathionine_beta-synthase activity : protective effect of an analog of the human albumin N-terminus .
6825304	0	copper	17,23	cystathionine_beta-synthase	63,90	copper	cystathionine beta-synthase	MESH:D003300	875	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|homocystinuria homocystinuria|amod|due due|nmod|deficiency deficiency|amod|END_ENTITY	Increased plasma copper in patients with homocystinuria due to cystathionine_beta-synthase deficiency .
10535524	0	copper	49,55	cytochrome_b	28,40	copper	cytochrome b	MESH:D003300	4519	Chemical	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	Regulation of mitochondrial cytochrome_b mRNA by copper in cultured human hepatoma cells and rat liver .
24327293	0	copper	40,46	divalent_metal_transporter_1	6,34	copper	divalent metal transporter 1	MESH:D003300	4891	Chemical	Gene	transporter|compound|START_ENTITY transporter|nsubj|END_ENTITY	Mouse divalent_metal_transporter_1 is a copper transporter in HEK293 cells .
3179263	0	copper	4,10	dopamine_beta-hydroxylase	20,45	copper	dopamine beta-hydroxylase	MESH:D003300	280758(Tax:9913)	Chemical	Gene	sites|compound|START_ENTITY sites|nmod|END_ENTITY	The copper sites of dopamine_beta-hydroxylase : an X-ray absorption spectroscopic study .
1155252	0	copper	19,25	ferrochelatase	73,87	copper	ferrochelatase	MESH:D003300	361338(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY biosynthesis|nsubj|role biosynthesis|nmod|END_ENTITY	A possible role of copper in the regulation of heme biosynthesis through ferrochelatase .
15532727	0	copper	61,67	ferrochelatase	45,59	copper	ferrochelatase	MESH:D003300	2235	Chemical	Gene	activation|compound|START_ENTITY Cloning|dep|activation Cloning|nmod|END_ENTITY	Cloning and characterization of chironomidae ferrochelatase : copper activation of the purified ferrochelatase .
15532727	0	copper	61,67	ferrochelatase	95,109	copper	ferrochelatase	MESH:D003300	2235	Chemical	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Cloning and characterization of chironomidae ferrochelatase : copper activation of the purified ferrochelatase .
3203160	0	copper	10,16	growth_hormone	43,57	copper	growth hormone	MESH:D003300	2688	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|nmod|END_ENTITY	Effect of copper on the secretion of human growth_hormone .
15634665	0	copper	56,62	hCTR1	33,38	copper	hCtr1	MESH:D003300	1317	Chemical	Gene	uptake|compound|START_ENTITY uptake|amod|END_ENTITY	Stable plasma membrane levels of hCTR1 mediate cellular copper uptake .
16356544	0	copper	61,67	hCTR1	80,85	copper	hCTR1	MESH:D003300	1317	Chemical	Gene	regulation|nmod|START_ENTITY transporter|nsubj|regulation transporter|dobj|END_ENTITY	Expression , localisation and hormone regulation of the human copper transporter hCTR1 in placenta and choriocarcinoma Jeg-3 cells .
19240214	0	copper	41,47	hCTR1	60,65	copper	hCTR1	MESH:D003300	1317	Chemical	Gene	transporter|compound|START_ENTITY structure|nmod|transporter END_ENTITY|nsubj|structure	Three-dimensional structure of the human copper transporter hCTR1 .
19740744	0	copper	61,67	hCTR1	30,35	copper	hCTR1	MESH:D003300	1317	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|appos|transporter	Copper-dependent recycling of hCTR1 , the human high affinity copper transporter .
22552365	0	copper	19,25	hCTR1	90,95	copper	hCTR1	MESH:D003300	1317	Chemical	Gene	transport|compound|START_ENTITY Comparison|nmod|transport mediated|nsubj|Comparison mediated|nmod|copper_transporter_1 copper_transporter_1|appos|END_ENTITY	Comparison between copper and cisplatin transport mediated by human copper_transporter_1 -LRB- hCTR1 -RRB- .
23543413	0	copper	62,68	hCTR1	31,36	copper	hCTR1	MESH:D003300	1317	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|appos|transporter	A re-evaluation of the role of hCTR1 , the human high-affinity copper transporter , in platinum-drug entry into human cells .
23658018	0	copper	23,29	hCTR1	71,76	copper	hCTR1	MESH:D003300	1317	Chemical	Gene	transport|compound|START_ENTITY Rate|nmod|transport Rate|nmod|copper_transporter_1 copper_transporter_1|appos|END_ENTITY	Rate and regulation of copper transport by human copper_transporter_1 -LRB- hCTR1 -RRB- .
23962988	0	copper	74,80	hCTR1	94,99	copper	hCTR1	MESH:D003300	1317	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Kinetics and thermodynamics of metal binding to the N-terminus of a human copper transporter , hCTR1 .
9207117	0	copper	24,30	hCTR1	0,5	copper	hCTR1	MESH:D003300	1317	Chemical	Gene	uptake|compound|START_ENTITY gene|nmod|uptake END_ENTITY|dep|gene	hCTR1 : a human gene for copper uptake identified by complementation in yeast .
12501239	0	copper	59,65	hCtr1	79,84	copper	hCtr1	MESH:D003300	1317	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Copper-stimulated endocytosis and degradation of the human copper transporter , hCtr1 .
24132751	0	copper	32,38	hCtr1	52,57	copper	hCtr1	MESH:D003300	1317	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Regulation of the high-affinity copper transporter -LRB- hCtr1 -RRB- expression by cisplatin and heavy metals .
26622894	0	copper	18,24	hCtr1	38,43	copper	hCtr1	MESH:D003300	1317	Chemical	Gene	START_ENTITY|amod|transporters transporters|dep|END_ENTITY	Expression of the copper transporters hCtr1 , ATP7A and ATP7B is associated with the response to chemotherapy and survival time in patients with resected non-small cell lung_cancer .
11229523	0	copper	57,63	hemopexin	91,100	copper	hemopexin	MESH:D003300	3263	Chemical	Gene	START_ENTITY|nmod|system system|amod|END_ENTITY	Links between cell-surface events involving redox-active copper and gene regulation in the hemopexin heme transport system .
19846304	0	copper	121,127	histatin-5	65,75	copper	histatin-5	MESH:D003300	3347	Chemical	Gene	complex|compound|START_ENTITY binding|nmod|complex role|dep|binding role|nmod|copper copper|nmod|activity activity|nmod|END_ENTITY	A plausible role of salivary copper in antimicrobial activity of histatin-5 -- metal binding and oxidative activity of its copper complex .
19846304	0	copper	29,35	histatin-5	65,75	copper	histatin-5	MESH:D003300	3347	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	A plausible role of salivary copper in antimicrobial activity of histatin-5 -- metal binding and oxidative activity of its copper complex .
22180012	0	copper	11,17	insulin-like_growth_factor-1	62,90	copper	insulin-like growth factor-1	MESH:D003300	101055342	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of copper on proliferation and autocrine secretion of insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- and IGF-binding_protein-3 -LRB- IGFBP-3 -RRB- in chondrocytes from newborn pigs in vitro .
3908962	0	copper	254,260	luteinizing_hormone_releasing_hormone	103,140	copper	luteinizing hormone releasing hormone	MESH:D003300	25194(Tax:10116)	Chemical	Gene	sites|nmod|START_ENTITY affinity|nmod|sites increase|dobj|affinity androgens|xcomp|increase evidence|acl:relcl|androgens Effects|dep|evidence Effects|nmod|age age|nmod|rats rats|nmod|process process|nmod|release release|nmod|END_ENTITY	Effects of castration and maturational age of male rats on the process of copper-stimulated release of luteinizing_hormone_releasing_hormone from median eminence explants : evidence that androgens increase the affinity of the copper-interactive sites for copper .
1674861	0	copper	50,56	lysyl_oxidase	100,113	copper	lysyl oxidase	MESH:D003300	24914(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	Purification , properties and influence of dietary copper on accumulation and functional activity of lysyl_oxidase in rat skin .
16128366	0	copper	11,17	matrix_metalloproteinase-2	83,109	copper	matrix metalloproteinase-2	MESH:D003300	81686(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	Effects of copper and zinc on the production of homocysteine-induced extracellular matrix_metalloproteinase-2 in cultured rat vascular smooth muscle cells .
23875773	0	copper	42,48	neurokinin_B	23,35	copper	neurokinin B	MESH:D003300	6866	Chemical	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	The tachykinin peptide neurokinin_B binds copper forming an unusual -LSB- CuII -LRB- NKB -RRB- 2 -RSB- complex and inhibits copper uptake into 1321N1 astrocytoma cells .
24650723	0	copper	42,48	neurokinin_B	23,35	copper	neurokinin B	MESH:D003300	6866	Chemical	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	The tachykinin peptide neurokinin_B binds copper -LRB- I -RRB- and silver -LRB- I -RRB- and undergoes quasi-reversible electrochemistry : towards a new function for the peptide in the brain .
9396570	0	copper	9,15	peptidylglycine_alpha-amidating_monooxygenase	38,83	copper	peptidylglycine alpha-amidating monooxygenase	MESH:D003300	5066	Chemical	Gene	stimulation|compound|START_ENTITY stimulation|nmod|END_ENTITY	In vitro copper stimulation of plasma peptidylglycine_alpha-amidating_monooxygenase in Menkes_disease variant with occipital horns .
15080705	0	copper	46,52	peptidylglycine_alpha-hydroxylating_monooxygenase	61,110	copper	peptidylglycine alpha-hydroxylating monooxygenase	MESH:D003300	5066	Chemical	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Oxygen activation by the noncoupled binuclear copper site in peptidylglycine_alpha-hydroxylating_monooxygenase .
15134448	0	copper	46,52	peptidylglycine_alpha-hydroxylating_monooxygenase	61,110	copper	peptidylglycine alpha-hydroxylating monooxygenase	MESH:D003300	5066	Chemical	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Oxygen activation by the noncoupled binuclear copper site in peptidylglycine_alpha-hydroxylating_monooxygenase .
10708581	0	copper	67,73	prion_protein	45,58	copper	prion protein	MESH:D003300	5621	Chemical	Gene	reduces|dobj|START_ENTITY reduces|nsubj|region region|nmod|END_ENTITY	The N-terminal tandem repeat region of human prion_protein reduces copper : role of tryptophan residues .
11900542	0	copper	26,32	prion_protein	79,92	copper	prion protein	MESH:D003300	5621	Chemical	Gene	features|nmod|START_ENTITY features|dobj|sites sites|nmod|domain domain|nmod|END_ENTITY	Molecular features of the copper binding sites in the octarepeat domain of the prion_protein .
12500977	0	copper	47,53	prion_protein	14,27	copper	prion protein	MESH:D003300	19122(Tax:10090)	Chemical	Gene	increases|dobj|START_ENTITY increases|nsubj|Expression Expression|nmod|END_ENTITY	Expression of prion_protein increases cellular copper binding and antioxidant enzyme activities but not copper delivery .
15449710	0	copper	80,86	prion_protein	9,22	copper	prion protein	MESH:D003300	5621	Chemical	Gene	binding|compound|START_ENTITY degradation|nmod|binding acquires|nmod|degradation acquires|nsubj|END_ENTITY	Cellular prion_protein acquires resistance to proteolytic degradation following copper ion binding .
15670838	0	copper	14,20	prion_protein	44,57	copper	prion protein	MESH:D003300	5621	Chemical	Gene	ions|compound|START_ENTITY regulate|nsubj|ions regulate|xcomp|expression expression|nsubj|END_ENTITY	Extracellular copper ions regulate cellular prion_protein -LRB- PrPC -RRB- expression and metabolism in neuronal cells .
15952778	0	copper	111,117	prion_protein	53,66	copper	prion protein	MESH:D003300	5621	Chemical	Gene	uptake|compound|START_ENTITY dependence|nmod|uptake Copper_reduction|dep|dependence Copper_reduction|nmod|region region|nmod|END_ENTITY	Copper_reduction by the octapeptide repeat region of prion_protein : pH dependence and implications in cellular copper uptake .
17059225	0	copper	16,22	prion_protein	38,51	copper	prion protein	MESH:D003300	5621	Chemical	Gene	START_ENTITY|amod|binding binding|nmod|domain domain|compound|END_ENTITY	The affinity of copper binding to the prion_protein octarepeat domain : evidence for negative cooperativity .
17389057	0	copper	67,73	prion_protein	103,116	copper	prion protein	MESH:D003300	5621	Chemical	Gene	interactions|nmod|START_ENTITY review|nmod|interactions review|nmod|END_ENTITY	Trace elements and prion_diseases : a review of the interactions of copper , manganese and zinc with the prion_protein .
17573247	0	copper	45,51	prion_protein	67,80	copper	prion protein	MESH:D003300	19122(Tax:10090)	Chemical	Gene	START_ENTITY|amod|binding binding|nmod|END_ENTITY	Dual polarisation interferometry analysis of copper binding to the prion_protein : evidence for two folding states .
17644786	0	copper	24,30	prion_protein	115,128	copper	prion protein	MESH:D003300	281427(Tax:9913)	Chemical	Gene	Exposure|nmod|START_ENTITY alter|nsubj|Exposure alter|dobj|characteristics characteristics|compound|END_ENTITY	Exposure to low dietary copper or low_copper coupled with high dietary manganese for one year does not alter brain prion_protein characteristics in the mature cow .
19048309	0	copper	80,86	prion_protein	94,107	copper	prion protein	MESH:D003300	5621	Chemical	Gene	histidine|nmod|START_ENTITY histidine|nmod|octarepeat octarepeat|compound|END_ENTITY	Modeling the interplay of glycine protonation and multiple histidine binding of copper in the prion_protein octarepeat subdomains .
19140013	0	copper	4,10	prion_protein	26,39	copper	prion protein	MESH:D003300	5621	Chemical	Gene	START_ENTITY|amod|binding binding|nmod|END_ENTITY	Can copper binding to the prion_protein generate a misfolded form of the protein ?
19184131	0	copper	17,23	prion_protein	56,69	copper	prion protein	MESH:D003300	5621	Chemical	Gene	environment|compound|START_ENTITY environment|nmod|END_ENTITY	Insight into the copper coordination environment in the prion_protein through density functional theory calculations of EPR parameters .
19233277	11	copper	1536,1542	prion_protein	1650,1663	copper	prion protein	MESH:D003300	281427(Tax:9913)	Chemical	Gene	metabolism|compound|START_ENTITY clearly|nmod|metabolism disturbance|nmod|clearly demonstrates|nsubj|disturbance demonstrates|dobj|role role|nmod|END_ENTITY	The disturbance to copper metabolism , as a result of altered prion_protein expression clearly demonstrates the important role of the prion_protein in copper metabolism .
19233277	11	copper	1667,1673	prion_protein	1650,1663	copper	prion protein	MESH:D003300	281427(Tax:9913)	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	The disturbance to copper metabolism , as a result of altered prion_protein expression clearly demonstrates the important role of the prion_protein in copper metabolism .
19561303	0	copper	38,44	prion_protein	60,73	copper	prion protein	MESH:D003300	5621	Chemical	Gene	implications|nmod|START_ENTITY implications|amod|binding binding|nmod|END_ENTITY	Functional implications of multistage copper binding to the prion_protein .
19957168	0	copper	25,31	prion_protein	120,133	copper	prion protein	MESH:D003300	24686(Tax:10116)	Chemical	Gene	mechanisms|compound|START_ENTITY analysis|nmod|mechanisms analysis|dep|contribution contribution|nmod|END_ENTITY	Fluorimetric analysis of copper transport mechanisms in the b104 neuroblastoma cell model : a contribution from cellular prion_protein to copper supplying .
21537833	0	copper	110,116	prion_protein	13,26	copper	prion protein	MESH:D003300	5621	Chemical	Gene	ion|compound|START_ENTITY weakens|nmod|ion weakens|nsubj|Knockdown Knockdown|nmod|END_ENTITY	Knockdown of prion_protein -LRB- PrP -RRB- by RNA interference weakens the protective activity of wild-type PrP against copper ion and antagonizes the cytotoxicity of fCJD-associated PrP mutants in cultured cells .
24102071	0	copper	106,112	prion_protein	153,166	copper	prion protein	MESH:D003300	5621	Chemical	Gene	START_ENTITY|amod|binding binding|nmod|octarepeat octarepeat|nmod|END_ENTITY	New insights into metal interactions with the prion_protein : EXAFS analysis and structure calculations of copper binding to a single octarepeat from the prion_protein .
24102071	0	copper	106,112	prion_protein	46,59	copper	prion protein	MESH:D003300	5621	Chemical	Gene	analysis|nmod|START_ENTITY insights|dep|analysis insights|nmod|interactions interactions|nmod|END_ENTITY	New insights into metal interactions with the prion_protein : EXAFS analysis and structure calculations of copper binding to a single octarepeat from the prion_protein .
24557708	0	copper	108,114	prion_protein	80,93	copper	prion protein	MESH:D003300	5621	Chemical	Gene	peptides|nmod|START_ENTITY peptides|nsubj|studies studies|nmod|interaction interaction|nmod|END_ENTITY	Biophysical and morphological studies on the dual interaction of non-octarepeat prion_protein peptides with copper and nucleic_acids .
26482532	0	copper	19,25	prion_protein	46,59	copper	prion protein	MESH:D003300	5621	Chemical	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	The non-octarepeat copper binding site of the prion_protein is a key regulator of prion conversion .
9414160	0	copper	33,39	prion_protein	13,26	copper	prion protein	MESH:D003300	281427(Tax:9913)	Chemical	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	The cellular prion_protein binds copper in vivo .
9523587	0	copper	11,17	prion_protein	33,46	copper	prion protein	MESH:D003300	19122(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|neurons neurons|amod|END_ENTITY	Effects of copper on survival of prion_protein knockout neurons and glia .
17999015	0	copper	13,19	snail	85,90	copper	snail	MESH:D003300	6615	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of copper on the feeding rate , growth and reproduction of the golden apple snail , Pomacea canaliculata Lamarck .
20934807	0	copper	19,25	snail	98,103	copper	snail	MESH:D003300	6615	Chemical	Gene	effects|compound|START_ENTITY Bioaccumulation|nmod|effects Bioaccumulation|nmod|L L|compound|END_ENTITY	Bioaccumulation of copper and toxic effects on feeding , growth , fecundity and development of pond snail Lymnaea luteola L .
21840034	0	copper	29,35	snail	64,69	copper	snail	MESH:D003300	6615	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Histopathological effects of copper and lithium in the ramshorn snail , Marisa cornuarietis -LRB- Gastropoda , Prosobranchia -RRB- .
9151438	0	copper	16,22	snail	49,54	copper	snail	MESH:D003300	6615	Chemical	Gene	Accumulation|nmod|START_ENTITY Accumulation|nmod|END_ENTITY	Accumulation of copper , nickel , lead and zinc by snail , Lunella coronatus and pearl oyster , Pinctada radiata from the Kuwait coast before and after the Gulf War oil spill .
21110139	0	copper	23,29	somatostatin	33,45	copper	somatostatin	MESH:D003300	494469(Tax:9823)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|compound|END_ENTITY	Effect of high dietary copper on somatostatin and growth_hormone-releasing_hormone levels in the hypothalami of growing pigs .
18948262	0	copper	89,95	superoxide_dismutase_1	15,37	copper	superoxide dismutase 1	MESH:D003300	39251(Tax:7227)	Chemical	Gene	chaperone|compound|START_ENTITY deficient|nmod|chaperone deficient|nsubj|Instability Instability|nmod|END_ENTITY	Instability of superoxide_dismutase_1 of Drosophila in mutants deficient for its cognate copper chaperone .
21409224	0	copper	76,82	superoxide_dismutase_1	30,52	copper	superoxide dismutase 1	MESH:D003300	6647	Chemical	Gene	homeostasis|compound|START_ENTITY chaperone|nmod|homeostasis chaperone|nmod|END_ENTITY	Roles of copper chaperone for superoxide_dismutase_1 and metallothionein in copper homeostasis .
21409224	0	copper	9,15	superoxide_dismutase_1	30,52	copper	superoxide dismutase 1	MESH:D003300	6647	Chemical	Gene	Roles|nmod|START_ENTITY chaperone|nsubj|Roles chaperone|nmod|END_ENTITY	Roles of copper chaperone for superoxide_dismutase_1 and metallothionein in copper homeostasis .
11959576	0	copper	37,43	tcrB	0,4	copper	tcrB	MESH:D003300	106506754	Chemical	Gene	resistance|compound|START_ENTITY conferring|dobj|resistance gene|acl|conferring END_ENTITY|appos|gene	tcrB , a gene conferring transferable copper resistance in Enterococcus_faecium : occurrence , transferability , and linkage to macrolide and glycopeptide resistance .
20500052	0	copper	35,41	tcrB	14,18	copper	tcrB	MESH:D003300	106506754	Chemical	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	Occurrence of tcrB , a transferable copper resistance gene , in fecal enterococci of swine .
424657	0	copper	11,17	transferrin	29,40	copper	transferrin	MESH:D003300	24825(Tax:10116)	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of copper to mucosal transferrin and inhibition of intestinal iron absorption in rats .
6309242	0	copper	37,43	transferrin	63,74	copper	transferrin	MESH:D003300	7018	Chemical	Gene	complexes|compound|START_ENTITY resonance|nmod|complexes resonance|nmod|END_ENTITY	Electron-nuclear double resonance of copper complexes of human transferrin .
10838090	0	copper	34,40	tyrosinase	49,59	copper	tyrosinase	MESH:D003300	7299	Chemical	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	EPR study of the dinuclear active copper site of tyrosinase from Streptomyces antibioticus .
3861140	0	copper	10,16	xanthine_dehydrogenase	32,54	copper	xanthine dehydrogenase	MESH:D003300	497811(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of copper on blood serum xanthine_dehydrogenase in rats given D-L-ethionine .
11550893	0	copper-zinc_superoxide	23,45	CuZnSOD	57,64	copper-zinc superoxide	CuZnSOD	null	39251(Tax:7227)	Chemical	Gene	dismutase|amod|START_ENTITY dismutase|appos|END_ENTITY	Low-activity allele of copper-zinc_superoxide dismutase -LRB- CuZnSOD -RRB- in Drosophila increases paraquat genotoxicity but does not affect near UV radiation damage .
18502742	0	copper-zinc_superoxide	114,136	CuZnSOD	148,155	copper-zinc superoxide	CuZnSOD	null	20655(Tax:10090)	Chemical	Gene	dismutase|amod|START_ENTITY dismutase|appos|END_ENTITY	Maternal blood glucose levels determine the severity of diabetic_embryopathy in mice with different expression of copper-zinc_superoxide dismutase -LRB- CuZnSOD -RRB- .
22761419	0	copper-zinc_superoxide	42,64	SOD1	76,80	copper-zinc superoxide	SOD1	null	6647	Chemical	Gene	dismutase|amod|START_ENTITY dismutase|appos|END_ENTITY	Ataxin-3 regulates aggresome formation of copper-zinc_superoxide dismutase -LRB- SOD1 -RRB- by editing K63-linked polyubiquitin chains .
22972774	0	copper-zinc_superoxide	15,37	SOD1	49,53	copper-zinc superoxide	SOD1	null	6647	Chemical	Gene	dismutase|amod|START_ENTITY dismutase|appos|END_ENTITY	Association of copper-zinc_superoxide dismutase -LRB- SOD1 -RRB- and manganese superoxide dismutase -LRB- SOD2 -RRB- genes with nonsyndromic myelomeningocele .
23592792	0	copper-zinc_superoxide	7,29	SOD1	41,45	copper-zinc superoxide	SOD1	null	6647	Chemical	Gene	dismutase|amod|START_ENTITY dismutase|appos|END_ENTITY	Mutant copper-zinc_superoxide dismutase -LRB- SOD1 -RRB- induces protein secretion pathway alterations and exosome release in astrocytes : implications for disease spreading and motor neuron pathology in amyotrophic_lateral_sclerosis .
2963717	0	copper-zinc_superoxide	48,70	SOD1	82,86	copper-zinc superoxide	SOD1	null	6647	Chemical	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Regular trisomy 21 not accompanied by increased copper-zinc_superoxide dismutase -LRB- SOD1 -RRB- activity .
9867871	0	copper-zinc_superoxide	10,32	SOD1	49,53	copper-zinc superoxide	SOD1	null	6647	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The human copper-zinc_superoxide dismutase gene -LRB- SOD1 -RRB- proximal promoter is regulated by Sp1 , Egr-1 , and WT1 via non-canonical binding sites .
8749044	0	copper-zinc_superoxide	68,90	monoamine_oxidase	49,66	copper-zinc superoxide	monoamine oxidase	null	29253(Tax:10116)	Chemical	Gene	dismutase|amod|START_ENTITY dismutase|amod|END_ENTITY	The effect of glucocorticoids on the activity of monoamine_oxidase , copper-zinc_superoxide dismutase and catalase in the rat hypothalamus .
22258826	0	copper_chelate	31,45	P-glycoprotein	57,71	copper chelate	P-glycoprotein	null	5243	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	The molecular interaction of a copper_chelate with human P-glycoprotein .
23808795	0	copper_porphyrin	67,83	CO2	29,32	copper porphyrin	CO2	null	717	Chemical	Gene	capture|nmod|START_ENTITY capture|compound|END_ENTITY	Chemical adsorption enhanced CO2 capture and photoreduction over a copper_porphyrin based metal organic framework .
16730829	0	copper_sulfate	51,65	HSP70	33,38	copper sulfate	HSP70	MESH:D019327	3308	Chemical	Gene	promoter|nmod|START_ENTITY promoter|compound|END_ENTITY	Specific activation of the human HSP70 promoter by copper_sulfate in mosaic transgenic zebrafish .
19116768	0	copper_sulfate	49,63	hsp70	34,39	copper sulfate	hsp70	MESH:D019327	387608(Tax:7955)	Chemical	Gene	genes|nmod|START_ENTITY genes|amod|END_ENTITY	Induction of phase II enzymes and hsp70 genes by copper_sulfate through the electrophile-responsive element -LRB- EpRE -RRB- : insights obtained from a transgenic zebrafish model carrying an orthologous EpRE sequence of mammalian origin .
19656454	0	coproporphyrin	42,56	Multidrug-Resistance_Protein_2	8,38	coproporphyrin	Multidrug-Resistance Protein 2	CHEBI:23388	24891(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|nmod|transport	Role of Multidrug-Resistance_Protein_2 in coproporphyrin transport : results from experimental studies in bile fistula rat models .
26383540	4	coproporphyrins_I_and_III	492,517	OATP1B1	534,541	coproporphyrins I and III	OATP1B3	null	28234	Chemical	Gene	transport|nmod|START_ENTITY mediated|nsubjpass|transport mediated|nmod|END_ENTITY	It was hypothesized that transport of coproporphyrins_I_and_III was mediated by OATP1B1 and OATP1B3 .
203501	0	cordycepin	10,20	CRF	24,27	cordycepin	CRF	MESH:C058120	81648(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|stimulation stimulation|compound|END_ENTITY	Effect of cordycepin on CRF stimulation and steroid inhibition of ACTH secretion by rat pituitary cells .
12398919	0	cordycepin	10,20	interleukin-10	24,38	cordycepin	interleukin-10	MESH:C058120	3586	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|production production|amod|END_ENTITY	Effect of cordycepin on interleukin-10 production of human peripheral blood mononuclear cells .
21621192	0	corticosteroid	18,32	TNF-a	36,41	corticosteroid	TNF-a	CHEBI:50858	24835(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Effect of inhaled corticosteroid on TNF-a production and alveolar_bone_loss in Wistar_rats .
6131369	1	corticosteroid	140,154	VIP	169,172	corticosteroid	VIP	CHEBI:50858	396323(Tax:9031)	Chemical	Gene	production|amod|START_ENTITY Stimulation|nmod|production Stimulation|nmod|END_ENTITY	Stimulation of corticosteroid production by VIP .
25910714	0	corticosteroid	65,79	Vanin-1	0,7	corticosteroid	Vanin-1	CHEBI:50858	8876	Chemical	Gene	START_ENTITY|nsubj|expression expression|amod|END_ENTITY	Vanin-1 expression and methylation discriminate pediatric asthma corticosteroid treatment response .
17664023	0	corticosteroid	123,137	calmodulin	29,39	corticosteroid	calmodulin	CHEBI:50858	24242(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|expression expression|compound|END_ENTITY	Trans-synaptic regulation of calmodulin gene expression after experimentally induced orofacial_inflammation and subsequent corticosteroid treatment in the principal sensory and motor trigeminal nuclei of the rat .
24077870	0	corticosteroid	14,28	cyclooxygenase_2	40,56	corticosteroid	cyclooxygenase 2	CHEBI:50858	5743	Chemical	Gene	therapy|amod|START_ENTITY effect|nmod|therapy effect|nmod|END_ENTITY	The effect of corticosteroid therapy on cyclooxygenase_2 , vascular_endothelial_growth_factor , and inducible_nitric_oxide_synthase expression levels in nasal_polyposis .
15679716	0	corticosteroid	18,32	thymus_and_activation-regulated_chemokine	54,95	corticosteroid	thymus and activation-regulated chemokine	CHEBI:50858	6361	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effect of inhaled corticosteroid on an immunoreactive thymus_and_activation-regulated_chemokine expression in the bronchial biopsies from asthmatics .
8142306	0	corticosteroid	48,62	urotensin_II	32,44	corticosteroid	urotensin II	CHEBI:50858	10911	Chemical	Gene	secretion|amod|START_ENTITY END_ENTITY|nmod|secretion	In vitro study of the effect of urotensin_II on corticosteroid secretion in the frog Rana ridibunda .
2841878	0	corticosteroids	41,56	ACTH	33,37	corticosteroids	ACTH	MESH:D000305	403659(Tax:9615)	Chemical	Gene	Evidence|nmod|START_ENTITY Evidence|nmod|END_ENTITY	Evidence for rapid inhibition of ACTH by corticosteroids in dogs .
18217399	0	corticosteroids	103,118	CD154	28,33	corticosteroids	CD154	MESH:D000305	959	Chemical	Gene	therapy|nmod|START_ENTITY END_ENTITY|nmod|therapy	Soluble CD40 and its ligand CD154 in patients with Graves ' _ ophthalmopathy during combined therapy with corticosteroids and teleradiotherapy .
18299252	0	corticosteroids	125,140	CD25	4,8	corticosteroids	CD25	MESH:D000305	3559	Chemical	Gene	+|nmod|START_ENTITY +|nsubj|END_ENTITY	CD4 + CD25 + regulatory T cells -LRB- TREG -RRB- in systemic_lupus_erythematosus -LRB- SLE -RRB- patients : the possible influence of treatment with corticosteroids .
10386245	0	corticosteroids	27,42	CHIF	46,50	corticosteroids	CHIF	MESH:D000305	64190(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Transcriptional control by corticosteroids of CHIF gene expression in the rat distal colon .
15572653	0	corticosteroids	19,34	CRH	0,3	corticosteroids	CRH	MESH:D000305	1392	Chemical	Gene	production|amod|START_ENTITY stimulation|nmod|production stimulation|compound|END_ENTITY	CRH stimulation of corticosteroids production in melanocytes is mediated by ACTH .
24665005	0	corticosteroids	27,42	Cadherin_5	0,10	corticosteroids	Cadherin 5	MESH:D000305	1003	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Cadherin_5 is regulated by corticosteroids and associated with central_serous_chorioretinopathy .
19200788	0	corticosteroids	39,54	IFN-gamma	76,85	corticosteroids	IFN-gamma	MESH:D000305	3458	Chemical	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	Inhibitory effect of Cyclosporin_A and corticosteroids on the production of IFN-gamma and IL-17 by T cells in Vogt-Koyanagi-Harada_syndrome .
15365604	4	corticosteroids	719,734	IL-2_receptor	743,756	corticosteroids	IL-2 receptor	MESH:D000305	3560	Chemical	Gene	START_ENTITY|nmod|antagonist antagonist|compound|END_ENTITY	A single perioperative dose of corticosteroids with an IL-2_receptor antagonist also seems as efficacious as standard steroid therapy .
12689659	0	corticosteroids	118,133	Interleukin_18	0,14	corticosteroids	Interleukin 18	MESH:D000305	3606	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|END_ENTITY	Interleukin_18 and transforming_growth_factor_beta1 in the serum of patients with Graves ' _ ophthalmopathy treated with corticosteroids .
8675215	0	corticosteroids	65,80	RANTES	14,20	corticosteroids	RANTES	MESH:D000305	6352	Chemical	Gene	effect|nmod|START_ENTITY Expression|dep|effect Expression|nmod|END_ENTITY	Expression of RANTES in human airway epithelial cells : effect of corticosteroids and interleukin-4 , _ -10 _ and _ -13 .
9150321	0	corticosteroids	10,25	RANTES	40,46	corticosteroids	RANTES	MESH:D000305	6352	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of corticosteroids on release of RANTES and sICAM-1 from cultured human bronchial epithelial cells , induced by TNF-alpha .
11753760	0	corticosteroids	102,117	Th1	6,9	corticosteroids	Th1	MESH:D000305	51497	Chemical	Gene	treated|nmod|START_ENTITY ophthalmopathy|acl|treated cytokine|nmod|ophthalmopathy cytokine|nsubj|END_ENTITY	Serum Th1 and Th2 profile cytokine level changes in patients with Graves ' _ ophthalmopathy treated with corticosteroids .
7561025	0	corticosteroids	14,29	Th1	33,36	corticosteroids	Th1	MESH:D000305	51497	Chemical	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Regulation by corticosteroids of Th1 and Th2 cytokine production in human CD4 + effector T cells generated from CD45RO - and CD45RO + subsets .
25316436	0	corticosteroids	10,25	VEGF	54,58	corticosteroids	VEGF	MESH:D000305	83785(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of corticosteroids and lung ventilation in the VEGF and NO pathways in congenital_diaphragmatic_hernia in rats .
26696093	0	corticosteroids	35,50	YKL-40	14,20	corticosteroids	YKL-40	MESH:D000305	1116	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Regulation of YKL-40 expression by corticosteroids : effect on pro-inflammatory macrophages in vitro and its modulation in COPD in vivo .
10988133	0	corticosteroids	9,24	interleukin-8	92,105	corticosteroids	interleukin-8	MESH:D000305	3576	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|END_ENTITY	Inhalant corticosteroids inhibit hyperosmolarity-induced , and cooling and rewarming-induced interleukin-8 and RANTES production by human bronchial epithelial cells .
11197112	0	corticosteroids	140,155	interleukin-8	50,63	corticosteroids	interleukin-8	MESH:D000305	3576	Chemical	Gene	response|nmod|START_ENTITY END_ENTITY|dep|response	Interleukin-1_beta , interleukin-5 , interleukin-6 , interleukin-8 , and tumor_necrosis_factor-alpha in chronic sinusitis : response to systemic corticosteroids .
10718920	0	corticosterone	62,76	5-HT1A_receptor	34,49	corticosterone	5-HT1A receptor	MESH:D003345	3350	Chemical	Gene	promoter|nmod|START_ENTITY promoter|amod|END_ENTITY	Transcriptional repression of the 5-HT1A_receptor promoter by corticosterone via mineralocorticoid receptors depends on the cellular context .
4320595	0	corticosterone	100,114	ACTH	20,24	corticosterone	ACTH	MESH:D003345	5443	Chemical	Gene	START_ENTITY|nmod|effects effects|nmod|END_ENTITY	In vitro effects of ACTH , angiotensins , serotonin and potassium on steroid output and conversion of corticosterone to aldosterone by isolated adrenal cells .
8673146	0	corticosterone	137,151	ACTH	98,102	corticosterone	ACTH	MESH:D003345	18976(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY effects|nmod|production effects|nmod|END_ENTITY	Increased plasma corticosterone levels in bovine growth_hormone -LRB- bGH -RRB- transgenic_mice : effects of ACTH , GH and IGF-I on in vitro adrenal corticosterone production .
20483644	0	corticosterone	103,117	Ang_II_receptor	49,64	corticosterone	Ang II receptor	MESH:D003345	24180(Tax:10116)	Chemical	Gene	mediated|nmod|START_ENTITY END_ENTITY|acl|mediated	Angiotensin_II-induced reduction in body mass is Ang_II_receptor mediated in association with elevated corticosterone .
16876769	0	corticosterone	8,22	BDNF	68,72	corticosterone	BDNF	MESH:D003345	24225(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|mRNA mRNA|appos|END_ENTITY	Chronic corticosterone decreases brain-derived_neurotrophic_factor -LRB- BDNF -RRB- mRNA and protein in the hippocampus , but not in the frontal cortex , of the rat .
22426399	0	corticosterone	62,76	BDNF	90,94	corticosterone	BDNF	MESH:D003345	12064(Tax:10090)	Chemical	Gene	treatment|compound|START_ENTITY treatment|nmod|END_ENTITY	Long-term behavioral and NMDA receptor effects of young-adult corticosterone treatment in BDNF heterozygous mice .
24816193	0	corticosterone	33,47	BDNF	76,80	corticosterone	BDNF	MESH:D003345	12064(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY reverses|dobj|effects reverses|nmod|expression expression|compound|END_ENTITY	Piperine reverses the effects of corticosterone on behavior and hippocampal BDNF expression in mice .
9824681	0	corticosterone	66,80	BDNF	18,22	corticosterone	BDNF	MESH:D003345	24225(Tax:10116)	Chemical	Gene	hippocampus|nmod|START_ENTITY hippocampus|nsubj|Downregulation Downregulation|nmod|mRNA mRNA|compound|END_ENTITY	Downregulation of BDNF mRNA and protein in the rat hippocampus by corticosterone .
7791083	0	corticosterone	112,126	CA1	134,137	corticosterone	CA1	MESH:D003345	310218(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|pyramidal pyramidal|compound|END_ENTITY	Modulation of the 5-hydroxytryptamine4 receptor-mediated response by short-term and long-term administration of corticosterone in rat CA1 hippocampal pyramidal neurons .
15059955	5	corticosterone	969,983	CORT	985,989	corticosterone	CORT	MESH:D003345	25305(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY secretion|appos|END_ENTITY	Although corticosterone -LRB- CORT -RRB- secretion temporally coincided with the decreasing phase of apo_A-IV in the hypothalamus , depletion of CORT by adrenalectomy significantly decreased , rather than increased , hypothalamic apo_A-IV mRNA and protein levels .
1330207	0	corticosterone	40,54	CRF	113,116	corticosterone	CRF	MESH:D003345	81648(Tax:10116)	Chemical	Gene	elevation|nmod|START_ENTITY mediated|nsubjpass|elevation mediated|nmod|corticotropin-releasing_factor corticotropin-releasing_factor|appos|END_ENTITY	The cocaine-induced elevation of plasma corticosterone is mediated by endogenous corticotropin-releasing_factor -LRB- CRF -RRB- in rats .
15953348	10	corticosterone	1456,1470	CRF	1495,1498	corticosterone	CRF	MESH:D003345	81648(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY elevated|nsubj|levels elevated|nmod|END_ENTITY	Hippocampal free corticosterone levels were elevated by CRF , urocortin_1_and_3 , but not by urocortin_2 .
15979366	0	corticosterone	59,73	CRF	4,7	corticosterone	CRF	MESH:D003345	404297(Tax:9031)	Chemical	Gene	concentrations|compound|START_ENTITY enhance|dobj|concentrations enhance|nsubj|END_ENTITY	ICV CRF and isolation stress differentially enhance plasma corticosterone concentrations in layer - and meat-type neonatal chicks .
19358863	0	corticosterone	58,72	CRF	123,126	corticosterone	CRF	MESH:D003345	12917(Tax:10090)	Chemical	Gene	induces|dobj|START_ENTITY induces|nmod|transgenic_mice transgenic_mice|compound|END_ENTITY	Transient forebrain over-expression of CRF induces plasma corticosterone and mild behavioural changes in adult conditional CRF transgenic_mice .
19358863	0	corticosterone	58,72	CRF	39,42	corticosterone	CRF	MESH:D003345	12917(Tax:10090)	Chemical	Gene	induces|dobj|START_ENTITY induces|nsubj|over-expression over-expression|nmod|END_ENTITY	Transient forebrain over-expression of CRF induces plasma corticosterone and mild behavioural changes in adult conditional CRF transgenic_mice .
6090854	0	corticosterone	22,36	CRF	104,107	corticosterone	CRF	MESH:D003345	81648(Tax:10116)	Chemical	Gene	course|nmod|START_ENTITY course|appos|concentrations concentrations|nmod|administration administration|compound|END_ENTITY	Time course of plasma corticosterone , 18-hydroxycorticosterone and aldosterone concentrations following CRF administration in the rat .
6320204	0	corticosterone	53,67	CRF	83,86	corticosterone	CRF	MESH:D003345	81648(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|administration administration|compound|END_ENTITY	Reduced ability of old male rats to release ACTH and corticosterone in response to CRF administration .
7889373	0	corticosterone	10,24	CRF	110,113	corticosterone	CRF	MESH:D003345	81648(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY reflex|nsubj|Effect reflex|nmod|corticotropin_releasing_factor corticotropin_releasing_factor|appos|END_ENTITY	Effect of corticosterone on the enhancement of the acoustic startle reflex by corticotropin_releasing_factor -LRB- CRF -RRB- .
9751481	9	corticosterone	1848,1862	CRF	1880,1883	corticosterone	CRF	MESH:D003345	81648(Tax:10116)	Chemical	Gene	response|amod|START_ENTITY response|nmod|END_ENTITY	The corticosterone response to i.v. CRF was unaffected by pulse phase in both strains , suggesting that a suprapituitary mechanism mediates the phase-dependent response to stress in the Lewis strain .
11295232	0	corticosterone	106,120	CRH	23,26	corticosterone	CRH	MESH:D003345	81648(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY END_ENTITY|dep|regulation	Norepinephrine-induced CRH and AVP gene transcription within the hypothalamus : differential regulation by corticosterone .
12855418	0	corticosterone	9,23	CRH	60,63	corticosterone	CRH	MESH:D003345	81648(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|responses responses|nmod|END_ENTITY	Elevated corticosterone and inhibition of ACTH responses to CRH and ether in the neonatal rat : effect of hypoxia from birth .
22191943	0	corticosterone	33,47	CRH	57,60	corticosterone	CRH	MESH:D003345	12918(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|receptors receptors|compound|END_ENTITY	Nicotine stimulates secretion of corticosterone via both CRH and AVP receptors .
19762876	0	corticosterone	69,83	Calcitonin	0,10	corticosterone	Calcitonin	MESH:D003345	396256(Tax:9031)	Chemical	Gene	production|compound|START_ENTITY increases|dobj|production increases|nsubj|END_ENTITY	Calcitonin directly increases adrenocorticotropic hormone-stimulated corticosterone production in the hen adrenal gland .
1846581	0	corticosterone	58,72	Corticotropin-releasing_hormone	0,31	corticosterone	Corticotropin-releasing hormone	MESH:D003345	81648(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Corticotropin-releasing_hormone -LRB- CRH -RRB- directly stimulates corticosterone secretion by the rat adrenal gland .
21153231	0	corticosterone	11,25	GnRH	156,160	corticosterone	GnRH	MESH:D003345	25194(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|presence presence|nmod|END_ENTITY	Effects of corticosterone and testosterone on pituitary gonadotropin content , secretion , bioactivity and messenger RNA levels in the presence or absence of GnRH in male rats .
7780034	0	corticosterone	117,131	IL-1	104,108	corticosterone	IL-1	MESH:D003345	111343(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY induced|dobj|production END_ENTITY|acl|induced	Ciliary_neurotrophic_factor -LRB- CNTF -RRB- induces serum_amyloid_A , hypoglycaemia and anorexia , and potentiates IL-1 induced corticosterone and IL-6 production in mice .
12765951	0	corticosterone	21,35	Leptin	0,6	corticosterone	Leptin	MESH:D003345	16846(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY activation|nmod|production activation|compound|END_ENTITY	Leptin activation of corticosterone production in hepatocytes may contribute to the reversal of obesity and hyperglycemia in leptin-deficient_ob / ob_mice .
24685581	0	corticosterone	54,68	Leptin	0,6	corticosterone	Leptin	MESH:D003345	16846(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY lung_injury|dep|role downregulates|dobj|lung_injury downregulates|nsubj|END_ENTITY	Leptin downregulates LPS-induced lung_injury : role of corticosterone and insulin .
2164954	0	corticosterone	24,38	Neuropeptide_Y	0,14	corticosterone	Neuropeptide Y	MESH:D003345	24604(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY inhibits|dobj|secretion inhibits|nsubj|END_ENTITY	Neuropeptide_Y inhibits corticosterone secretion by isolated rat adrenocortical cells .
2309931	0	corticosterone	46,60	Neuropeptide_Y	0,14	corticosterone	Neuropeptide Y	MESH:D003345	24604(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY effect|nmod|activity END_ENTITY|dep|effect	Neuropeptide_Y in the hypothalamus : effect on corticosterone and single-unit activity .
8412501	0	corticosterone	34,48	Pancreatic_polypeptide	0,22	corticosterone	Pancreatic polypeptide	MESH:D003345	24677(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Pancreatic_polypeptide stimulates corticosterone secretion by isolated rat adrenocortical cells .
3577818	0	corticosterone	32,46	Prolactin	0,9	corticosterone	Prolactin	MESH:D003345	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|AVP AVP|compound|END_ENTITY	Prolactin , AVP , angiotensin_II , corticosterone and aldosterone in the rat during weaning .
17060050	0	corticosterone	16,30	SGK1	49,53	corticosterone	SGK1	MESH:D003345	29517(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY administration|nmod|expression expression|compound|END_ENTITY	Effect of brief corticosterone administration on SGK1 and RGS4 mRNA expression in rat hippocampus .
21655274	0	corticosterone	7,21	SGK1	32,36	corticosterone	SGK1	MESH:D003345	20393(Tax:10090)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Plasma corticosterone activates SGK1 and induces morphological changes in oligodendrocytes in corpus callosum .
221180	0	corticosterone	22,36	Y-1	116,119	corticosterone	Y-1	MESH:D003345	21355(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Inhibitory effects of corticosterone on cell proliferation and steroidogenesis in the mouse adrenal_tumor cell line Y-1 .
19229593	0	corticosterone	24,38	adenosine_deaminase	61,80	corticosterone	adenosine deaminase	MESH:D003345	419194(Tax:9031)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Antithetical effects of corticosterone and dibutyryl_cAMP on adenosine_deaminase in the gastrointestinal tract of chicken during postnatal development .
8750957	0	corticosterone	32,46	arginine_vasopressin	65,85	corticosterone	arginine vasopressin	MESH:D003345	24221(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	Membrane-mediated inhibition of corticosterone on the release of arginine_vasopressin from rat hypothalamic slices .
1360359	0	corticosterone	63,77	beta-endorphin	32,46	corticosterone	beta-endorphin	MESH:D003345	5443	Chemical	Gene	release|amod|START_ENTITY effects|nmod|release effects|nmod|END_ENTITY	In vivo and in vitro effects of beta-endorphin and naloxone on corticosterone and cortisol release in male and female water frog , Rana esculenta .
18662341	0	corticosterone	11,25	corticotrophin-releasing_hormone	29,61	corticosterone	corticotrophin-releasing hormone	MESH:D003345	81648(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|release release|amod|END_ENTITY	Effects of corticosterone on corticotrophin-releasing_hormone and gastrin-releasing_peptide release in response to an aversive stimulus in two regions of the forebrain -LRB- central nucleus of the amygdala and prefrontal cortex -RRB- .
22831701	0	corticosterone	156,170	corticotrophin-releasing_hormone	88,120	corticosterone	corticotrophin-releasing hormone	MESH:D003345	81648(Tax:10116)	Chemical	Gene	required|nmod|START_ENTITY required|nmod|regulation regulation|nmod|expression expression|compound|END_ENTITY	Intact catecholamine inputs to the forebrain are required for appropriate regulation of corticotrophin-releasing_hormone and vasopressin gene expression by corticosterone in the rat paraventricular nucleus .
9652969	0	corticosterone	30,44	corticotrophin-releasing_hormone	90,122	corticosterone	corticotrophin-releasing hormone	MESH:D003345	81648(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY elevated|dobj|levels Evidence|acl:relcl|elevated cause|nsubj|Evidence cause|nmod|expression expression|amod|END_ENTITY	Evidence that elevated plasma corticosterone levels are the cause of reduced hypothalamic corticotrophin-releasing_hormone gene expression in diabetes .
1309333	0	corticosterone	100,114	corticotropin-releasing_factor	22,52	corticosterone	corticotropin-releasing factor	MESH:D003345	81648(Tax:10116)	Chemical	Gene	control|nmod|START_ENTITY END_ENTITY|nmod|control	Physiological role of corticotropin-releasing_factor in the control of adrenocorticotropin-mediated corticosterone release from the rat adrenal gland .
10414997	0	corticosterone	39,53	corticotropin-releasing_hormone	74,105	corticosterone	corticotropin-releasing hormone	MESH:D003345	81648(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|compound|END_ENTITY	Independent and overlapping effects of corticosterone and testosterone on corticotropin-releasing_hormone and arginine_vasopressin mRNA expression in the paraventricular nucleus of the hypothalamus and stress-induced adrenocorticotropic hormone release .
15465594	0	corticosterone	92,106	corticotropin-releasing_hormone	18,49	corticosterone	corticotropin-releasing hormone	MESH:D003345	12918(Tax:10090)	Chemical	Gene	networks|amod|START_ENTITY role|nmod|networks Overproduction|dep|role Overproduction|nmod|formation formation|compound|blocks blocks|amod|END_ENTITY	Overproduction of corticotropin-releasing_hormone blocks germinal center formation : role of corticosterone and impaired follicular dendritic cell networks .
1850357	0	corticosterone	108,122	corticotropin-releasing_hormone	142,173	corticosterone	corticotropin-releasing hormone	MESH:D003345	81648(Tax:10116)	Chemical	Gene	responses|amod|START_ENTITY responses|acl|ovine ovine|dobj|END_ENTITY	Effects of short and long duration hypothyroidism and hyperthyroidism on the plasma adrenocorticotropin and corticosterone responses to ovine corticotropin-releasing_hormone in rats .
1331681	0	corticosterone	60,74	gamma-actin	14,25	corticosterone	gamma-actin	MESH:D003345	287876(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Modulation of gamma-actin and alpha 1-tubulin expression by corticosterone during neuronal plasticity in the hippocampus .
11444434	0	corticosterone	60,74	growth_hormone	32,46	corticosterone	growth hormone	MESH:D003345	378781(Tax:9031)	Chemical	Gene	secretion|nmod|START_ENTITY END_ENTITY|acl|secretion	Regulation of chicken embryonic growth_hormone secretion by corticosterone and triiodothyronine : evidence for a negative synergistic response .
8976527	0	corticosterone	8,22	interleukin-1_beta	60,78	corticosterone	interleukin-1 beta	MESH:D003345	24494(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|effects effects|nmod|END_ENTITY	Role of corticosterone in the behavioral effects of central interleukin-1_beta .
11551859	0	corticosterone	85,99	leptin	48,54	corticosterone	leptin	MESH:D003345	25608(Tax:10116)	Chemical	Gene	presence|nmod|START_ENTITY infused|nmod|presence infused|nmod|END_ENTITY	Lipid deposition in rats centrally infused with leptin in the presence or absence of corticosterone .
11597906	0	corticosterone	92,106	leptin	20,26	corticosterone	leptin	MESH:D003345	16846(Tax:10090)	Chemical	Gene	elevation|nmod|START_ENTITY mediated|nmod|elevation increases|parataxis|mediated increases|dobj|production production|compound|END_ENTITY	Hyperoxia increases leptin production : a mechanism mediated through endogenous elevation of corticosterone .
15492859	0	corticosterone	42,56	leptin	11,17	corticosterone	leptin	MESH:D003345	25608(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY fragments|nmod|secretion fragments|nsubj|Effects Effects|nmod|END_ENTITY	Effects of leptin and leptin fragments on corticosterone secretion and growth of cultured rat adrenocortical cells .
18191822	0	corticosterone	51,65	leptin	27,33	corticosterone	leptin	MESH:D003345	25608(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	Systemic administration of leptin decreases plasma corticosterone levels : role of hypothalamic norepinephrine .
9356047	0	corticosterone	26,40	leptin	8,14	corticosterone	leptin	MESH:D003345	3952	Chemical	Gene	secretion|amod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Central leptin stimulates corticosterone secretion at the onset of the dark phase .
7895055	0	corticosterone	96,110	neuropeptide_Y	13,27	corticosterone	neuropeptide Y	MESH:D003345	24604(Tax:10116)	Chemical	Gene	circulating|dobj|START_ENTITY relation|acl|circulating END_ENTITY|dep|relation	Hypothalamic neuropeptide_Y , its gene expression and receptor activity : relation to circulating corticosterone in adrenalectomized rats .
8087419	0	corticosterone	98,112	neuropeptide_Y	13,27	corticosterone	neuropeptide Y	MESH:D003345	24604(Tax:10116)	Chemical	Gene	light/dark|dobj|START_ENTITY relation|acl|light/dark END_ENTITY|dep|relation	Hypothalamic neuropeptide_Y and its gene expression : relation to light/dark cycle and circulating corticosterone .
8739887	0	corticosterone	74,88	neuropeptide_Y	48,62	corticosterone	neuropeptide Y	MESH:D003345	24604(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|administration administration|nmod|stimulates stimulates|amod|END_ENTITY	Acute intracerebroventricular administration of neuropeptide_Y stimulates corticosterone output and feeding but not insulin output in normal rats .
9048607	0	corticosterone	9,23	neuropeptide_Y	67,81	corticosterone	neuropeptide Y	MESH:D003345	24604(Tax:10116)	Chemical	Gene	required|nsubjpass|START_ENTITY required|nmod|induction induction|nmod|expression expression|amod|END_ENTITY	Elevated corticosterone is not required for the rapid induction of neuropeptide_Y gene expression by an overnight fast .
18423439	0	corticosterone	132,146	nicotinic_acetylcholine_receptor	14,46	corticosterone	nicotinic acetylcholine receptor	MESH:D003345	170945(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of brain nicotinic_acetylcholine_receptor in centrally administered corticotropin-releasing_factor-induced elevation of plasma corticosterone in rats .
17914980	0	corticosterone	22,36	ornithine_decarboxylase	40,63	corticosterone	ornithine decarboxylase	MESH:D003345	24609(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activity activity|amod|END_ENTITY	Regulatory effects of corticosterone on ornithine_decarboxylase activity during liver regeneration in rats .
3261683	0	corticosterone	10,24	phenylethanolamine_N-methyltransferase	56,94	corticosterone	phenylethanolamine N-methyltransferase	MESH:D003345	24661(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY Effect|nmod|treatment Effect|nmod|END_ENTITY	Effect of corticosterone treatment and adrenalectomy on phenylethanolamine_N-methyltransferase and catecholamines in brain stem and hypothalamic nuclei and superior cervical ganglion of rats .
18311602	0	corticosterone	82,96	phosphatidylethanolamine_binding_protein-1	17,59	corticosterone	phosphatidylethanolamine binding protein-1	MESH:D003345	29542(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY END_ENTITY|nmod|treatment	Reduction in rat phosphatidylethanolamine_binding_protein-1 -LRB- PEBP1 -RRB- after chronic corticosterone treatment may be paralleled by cognitive_impairment : a first study .
2344838	0	corticosterone	62,76	prolactin	42,51	corticosterone	prolactin	MESH:D003345	24683(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY effects|nmod|synthesis effects|nmod|levels levels|compound|END_ENTITY	Time-dependent effects of increased serum prolactin levels on corticosterone synthesis and secretion in male rats .
3556416	0	corticosterone	36,50	prolactin	90,99	corticosterone	prolactin	MESH:D003345	396453(Tax:9031)	Chemical	Gene	START_ENTITY|nmod|chickens chickens|acl|treated treated|nmod|END_ENTITY	Lipid metabolism indices and plasma corticosterone concentration in chickens treated with prolactin at different time points .
6541283	0	corticosterone	10,24	prolactin	32,41	corticosterone	prolactin	MESH:D003345	24683(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|response response|compound|END_ENTITY	Effect of corticosterone on the prolactin response to psychological and physical stress in rats .
8145895	0	corticosterone	119,133	prolactin	22,31	corticosterone	prolactin	MESH:D003345	24683(Tax:10116)	Chemical	Gene	levels|nmod|START_ENTITY rise|dobj|levels rise|nsubj|Analysis Analysis|nmod|END_ENTITY	Analysis of pituitary prolactin and adrenocortical response to ether , formalin or restraint in lactating rats : rise in corticosterone , but no increase in plasma prolactin levels after exposure to stress .
8699147	0	corticosterone	31,45	prolactin	67,76	corticosterone	prolactin	MESH:D003345	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Studies on the role of TRH and corticosterone in the regulation of prolactin and thyrotrophin secretion during lactation .
2155098	2	corticosterone	399,413	rat	436,439	corticosterone	AVP	MESH:D003345	24221(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	In the present study we have examined whether cGMP mediates the inhibitory effect of corticosterone in perifused isolated rat anterior pituitary cells .
10077325	0	corticosterone	61,75	stress-activated_protein_kinase_3	97,130	corticosterone	stress-activated protein kinase 3	MESH:D003345	60352(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Dehydroepiandrosterone antagonizes the neurotoxic effects of corticosterone and translocation of stress-activated_protein_kinase_3 in hippocampal primary cultures .
2830101	0	corticosterone	63,77	transcortin	17,28	corticosterone	transcortin	MESH:D003345	299270(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	The influence of transcortin on adrenocorticotropin-stimulated corticosterone production in monolayer cultured rat adrenal cells .
3040377	0	corticosterone	107,121	transcortin	50,61	corticosterone	transcortin	MESH:D003345	299270(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY sensitive|xcomp|inhibition sensitive|nmod|production production|amod|END_ENTITY	Plasma adrenocorticotropin is more sensitive than transcortin production or thymus weight to inhibition by corticosterone in rats .
6158712	0	corticotropin	35,48	ACTH	50,54	corticotropin	ACTH	MESH:D000324	5443	Chemical	Gene	distribution|nmod|START_ENTITY distribution|appos|END_ENTITY	Immunocytochemical distribution of corticotropin -LRB- ACTH -RRB- in monkey brain .
1711231	0	corticotropin	58,71	Basic_fibroblast_growth_factor	0,30	corticotropin	Basic fibroblast growth factor	MESH:D000324	2247	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	Basic_fibroblast_growth_factor expression is regulated by corticotropin in the human fetal adrenal : a model for adrenal growth regulation .
10375794	0	corticotropin	11,24	c-fos	44,49	corticotropin	c-fos	MESH:D000324	314322(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	-LSB- Effect of corticotropin on formalin-evoked c-fos expression of spinal cord and receptors analysis in rat -RSB- .
11350048	4	cortisol	732,740	11beta-HSD2	696,707	cortisol	11beta-HSD2	MESH:D006854	3291	Chemical	Gene	conversion|nmod|START_ENTITY conversion|amod|END_ENTITY	Ca2 + decreased the maximal velocity -LRB- Vmax -RRB- of the 11beta-HSD2 catalyzed conversion of cortisol to cortisone without altering the Km of 11beta-HSD2 for cortisol , indicating that Ca2 + modulates the catalytic efficiency rather than the substrate binding of 11beta-HSD2 .
10651756	0	cortisol	92,100	11beta-hydroxysteroid_dehydrogenase_type_1	25,67	cortisol	11beta-hydroxysteroid dehydrogenase type 1	MESH:D006854	3290	Chemical	Gene	metabolism|amod|START_ENTITY explain|dobj|metabolism explain|nsubj|inhibitors inhibitors|nmod|END_ENTITY	Endogenous inhibitors of 11beta-hydroxysteroid_dehydrogenase_type_1 do not explain abnormal cortisol metabolism in polycystic_ovary_syndrome .
12107245	0	cortisol	38,46	11beta-hydroxysteroid_dehydrogenase_type_1	92,134	cortisol	11beta-hydroxysteroid dehydrogenase type 1	MESH:D006854	3290	Chemical	Gene	metabolism|amod|START_ENTITY changes|nmod|metabolism increased|nsubj|changes increased|dobj|activity activity|amod|END_ENTITY	Tissue-specific changes in peripheral cortisol metabolism in obese women : increased adipose 11beta-hydroxysteroid_dehydrogenase_type_1 activity .
12553866	0	cortisol	11,19	11beta-hydroxysteroid_dehydrogenase_type_1	46,88	cortisol	11beta-hydroxysteroid dehydrogenase type 1	MESH:D006854	443409(Tax:9940)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of cortisol and oestradiol on hepatic 11beta-hydroxysteroid_dehydrogenase_type_1 and glucocorticoid receptor proteins in late-gestation sheep fetus .
17951535	0	cortisol	163,171	11beta-hydroxysteroid_dehydrogenase_type_1	106,148	cortisol	11beta-hydroxysteroid dehydrogenase type 1	MESH:D006854	3290	Chemical	Gene	_|nmod|START_ENTITY _|nmod|induction induction|nmod|expression expression|amod|END_ENTITY	Role of glucocorticoid_receptor and CCAAT/enhancer-binding _ protein_alpha in the feed-forward induction of 11beta-hydroxysteroid_dehydrogenase_type_1 expression by cortisol in human amnion fibroblasts .
10931104	12	cortisol	2265,2273	ACTH	2295,2299	cortisol	ACTH	MESH:D006854	5443	Chemical	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	The minimum cortisol response at 30 minutes in the 21 control subjects was 414 nmol/l and this was defined as the minimum normal cortisol response to 1 microg ACTH .
10971446	0	cortisol	57,65	ACTH	42,46	cortisol	ACTH	MESH:D006854	5443	Chemical	Gene	START_ENTITY|nsubj|relationship relationship|nmod|END_ENTITY	Dose-response relationship between plasma ACTH and serum cortisol in the insulin-hypoglycaemia test in 25 healthy subjects and 109 patients with pituitary_disease .
11232423	0	cortisol	57,65	ACTH	1,5	cortisol	ACTH	MESH:D006854	100071524(Tax:9796)	Chemical	Gene	horses|amod|START_ENTITY determination|nmod|horses test|nmod|determination test|compound|END_ENTITY	-LSB- ACTH stimulation test for the determination of salivary cortisol and of cortisol responses as markers of the training status/fitness of warm-blooded sports horses -RSB- .
11353684	0	cortisol	17,25	ACTH	60,64	cortisol	ACTH	MESH:D006854	5443	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Pregnancy alters cortisol feedback inhibition of stimulated ACTH : studies in adrenalectomized ewes .
12665982	0	cortisol	93,101	ACTH	86,90	cortisol	ACTH	MESH:D006854	5443	Chemical	Gene	hormone|amod|START_ENTITY hormone|appos|END_ENTITY	The influence of aspirin on exercise-induced changes in adrenocorticotrophic hormone -LRB- ACTH -RRB- , cortisol and aldosterone -LRB- ALD -RRB- concentrations .
1319730	0	cortisol	39,47	ACTH	19,23	cortisol	ACTH	MESH:D006854	5443	Chemical	Gene	synthesis|amod|START_ENTITY stimulation|nmod|synthesis stimulation|compound|END_ENTITY	The time-course of ACTH stimulation of cortisol synthesis by the immature ovine foetal adrenal gland .
14767873	0	cortisol	51,59	ACTH	226,230	cortisol	ACTH	MESH:D006854	5443	Chemical	Gene	concentrations|amod|START_ENTITY concentrations|dep|response response|nmod|END_ENTITY	Circulating adrenocorticotropic_hormone -LRB- ACTH -RRB- and cortisol concentrations in normal , appropriate-for-gestational-age newborns versus those with sepsis and respiratory_distress : Cortisol response to low-dose and standard-dose ACTH tests .
16233969	0	cortisol	23,31	ACTH	67,71	cortisol	ACTH	MESH:D006854	403659(Tax:9615)	Chemical	Gene	concentrations|amod|START_ENTITY concentrations|compound|END_ENTITY	Cortisol , aldosterone , cortisol precursor , androgen and endogenous ACTH concentrations in dogs with pituitary-dependant hyperadrenocorticism treated with trilostane .
16925461	0	cortisol	9,17	ACTH	41,45	cortisol	ACTH	MESH:D006854	5443	Chemical	Gene	test|amod|START_ENTITY test|compound|END_ENTITY	Salivary cortisol in low dose -LRB- 1 microg -RRB- ACTH test in healthy women : comparison with serum cortisol .
16925461	0	cortisol	91,99	ACTH	41,45	cortisol	ACTH	MESH:D006854	5443	Chemical	Gene	comparison|nmod|START_ENTITY test|dep|comparison test|compound|END_ENTITY	Salivary cortisol in low dose -LRB- 1 microg -RRB- ACTH test in healthy women : comparison with serum cortisol .
18271677	0	cortisol	33,41	ACTH	56,60	cortisol	ACTH	MESH:D006854	5443	Chemical	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|test test|compound|END_ENTITY	Comparison of total and salivary cortisol in a low-dose ACTH -LRB- Synacthen -RRB- test : influence of three-month oral contraceptives administration to healthy women .
1848739	0	cortisol	9,17	ACTH	59,63	cortisol	ACTH	MESH:D006854	5443	Chemical	Gene	levels|amod|START_ENTITY END_ENTITY|nsubj|levels	Salivary cortisol levels and their correlation with plasma ACTH levels in depressed patients before and after the DST .
188374	0	cortisol	61,69	ACTH	55,59	cortisol	ACTH	MESH:D006854	5443	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|analgesia analgesia|nmod|END_ENTITY	The effect of segmental epidural analgesia on maternal ACTH , cortisol and TSH during labour .
19119977	0	cortisol	16,24	ACTH	74,78	cortisol	ACTH	MESH:D006854	5443	Chemical	Gene	Baseline|dobj|START_ENTITY Baseline|nmod|testing testing|amod|END_ENTITY	Baseline plasma cortisol and ACTH concentrations and response to low-dose ACTH stimulation testing in ill foals .
204140	2	cortisol	386,394	ACTH	411,415	cortisol	ACTH	MESH:D006854	5443	Chemical	Gene	response|amod|START_ENTITY response|nmod|infusion infusion|compound|END_ENTITY	Basal plasma ACTH and cortisol levels and the cortisol response to 8 h ACTH infusion were comparable before and during short-term treatment .
20925018	0	cortisol	55,63	ACTH	128,132	cortisol	ACTH	MESH:D006854	5443	Chemical	Gene	activity|nmod|START_ENTITY sensitivity|nmod|activity sensitivity|dep|assessment assessment|nmod|profiles profiles|compound|END_ENTITY	Variable sensitivity to the glucocorticoid activity of cortisol in patients with primary_adrenal_insufficiency : assessment with ACTH profiles .
21036888	0	cortisol	18,26	ACTH	66,70	cortisol	ACTH	MESH:D006854	5443	Chemical	Gene	responses|amod|START_ENTITY Comparison|nmod|responses Comparison|nmod|END_ENTITY	Comparison of the cortisol responses to testing with two doses of ACTH in patients with suspected adrenal_insufficiency .
22514052	0	cortisol	26,34	ACTH	86,90	cortisol	ACTH	MESH:D006854	5443	Chemical	Gene	responses|nmod|START_ENTITY responses|appos|END_ENTITY	Differential responses of cortisol and corticosterone to adrenocorticotropic_hormone -LRB- ACTH -RRB- in a subterranean rodent -LRB- Ctenomys talarum -RRB- .
23242860	0	cortisol	118,126	ACTH	128,132	cortisol	ACTH	MESH:D006854	5443	Chemical	Gene	assessment|amod|START_ENTITY assessment|dep|END_ENTITY	Remission rate after transsphenoidal_surgery in patients with pathologically confirmed Cushing 's _ disease , the role of cortisol , ACTH assessment and immediate reoperation : a large single center experience .
23865937	10	cortisol	1094,1102	ACTH	1115,1119	cortisol	ACTH	MESH:D006854	5443	Chemical	Gene	response|amod|START_ENTITY response|nmod|END_ENTITY	The cortisol response to ACTH increased stepwise between the groups : 98 , 172 and 249 nm/pm -LRB- P = 0 000 , undetectable ACTH was set to 0 pm -RRB- .
2558479	0	cortisol	83,91	ACTH	60,64	cortisol	ACTH	MESH:D006854	5443	Chemical	Gene	secretion|amod|START_ENTITY concentrations|nmod|secretion concentrations|amod|END_ENTITY	Relationship of nocturnal plasma bioactive and immunoactive ACTH concentrations to cortisol secretion in normal men .
2996363	0	cortisol	31,39	ACTH	56,60	cortisol	ACTH	MESH:D006854	5443	Chemical	Gene	increases|amod|START_ENTITY block|nsubj|increases block|dobj|response response|compound|END_ENTITY	By 94 days of gestation plasma cortisol increases block ACTH response to hypotension in lamb fetuses .
3000118	0	cortisol	40,48	ACTH	94,98	cortisol	ACTH	MESH:D006854	5443	Chemical	Gene	secretion|amod|START_ENTITY secretion|compound|END_ENTITY	Cyclic Cushing 's _ syndrome combined with cortisol suppressible , dexamethasone non-suppressible ACTH secretion : a new variant of Cushing 's _ syndrome .
3032007	0	cortisol	65,73	ACTH	38,42	cortisol	ACTH	MESH:D006854	5443	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|inhibition inhibition|nmod|END_ENTITY	Negative-feedback inhibition of fetal ACTH secretion by maternal cortisol .
6094080	0	cortisol	32,40	ACTH	81,85	cortisol	ACTH	MESH:D006854	5443	Chemical	Gene	peak|nmod|START_ENTITY mediated|nsubjpass|peak mediated|nmod|END_ENTITY	The meal-related peak in plasma cortisol is not mediated by radioimmunoassayable ACTH .
6094080	5	cortisol	648,656	ACTH	597,601	cortisol	ACTH	MESH:D006854	5443	Chemical	Gene	peak|amod|START_ENTITY produce|dobj|peak necessary|xcomp|produce necessary|nsubj|levels levels|compound|END_ENTITY	In contrast , markedly elevated ACTH levels were necessary to produce a comparable cortisol peak by administration of ACTH .
6099512	0	cortisol	6,14	ACTH	0,4	cortisol	ACTH	MESH:D006854	5443	Chemical	Gene	response|amod|START_ENTITY END_ENTITY|dobj|response	ACTH , cortisol and beta-endorphin response to metyrapone testing during chronic methadone maintenance treatment in humans .
6266301	0	cortisol	8,16	ACTH	49,53	cortisol	ACTH	MESH:D006854	5443	Chemical	Gene	START_ENTITY|nmod|stimulation stimulation|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Plasma cortisol response after stimulation with ACTH in postmature newborns -LRB- author 's transl -RRB- -RSB- .
6273024	0	cortisol	89,97	ACTH	52,56	cortisol	ACTH	MESH:D006854	5443	Chemical	Gene	response|amod|START_ENTITY metyrapone|nmod|response response|acl|metyrapone response|compound|END_ENTITY	The short metyrapone test : comparison of the plasma ACTH response to metyrapone with the cortisol response to insulin-induced hypoglycaemia in patients with pituitary_disease .
6277837	0	cortisol	7,15	ACTH	38,42	cortisol	ACTH	MESH:D006854	403659(Tax:9615)	Chemical	Gene	response|amod|START_ENTITY response|nmod|END_ENTITY	Plasma cortisol response to exogenous ACTH in 22 dogs with hyperadrenocorticism caused by adrenocortical_neoplasia .
6303637	0	cortisol	47,55	ACTH	29,33	cortisol	ACTH	MESH:D006854	5443	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|effects effects|nmod|END_ENTITY	Negative feedback effects on ACTH secretion by cortisol in Cushing 's _ disease .
6318936	0	cortisol	42,50	ACTH	24,28	cortisol	ACTH	MESH:D006854	403659(Tax:9615)	Chemical	Gene	secretion|nmod|START_ENTITY END_ENTITY|acl|secretion	Feedback suppression of ACTH secretion by cortisol in dogs : lags after large signals equal those following very small signals .
8429271	0	cortisol	107,115	ACTH	75,79	cortisol	ACTH	MESH:D006854	5443	Chemical	Gene	levels|amod|START_ENTITY effect|nmod|levels Reproducibility|dep|effect Reproducibility|nmod|response response|nmod|stimulation stimulation|nmod|dose dose|nmod|END_ENTITY	Reproducibility of the cortisol response to stimulation with a low dose of ACTH -LRB- 1-24 -RRB- : the effect of basal cortisol levels and comparison of low-dose with high-dose secretory dynamics .
8429271	0	cortisol	23,31	ACTH	75,79	cortisol	ACTH	MESH:D006854	5443	Chemical	Gene	response|amod|START_ENTITY response|nmod|stimulation stimulation|nmod|dose dose|nmod|END_ENTITY	Reproducibility of the cortisol response to stimulation with a low dose of ACTH -LRB- 1-24 -RRB- : the effect of basal cortisol levels and comparison of low-dose with high-dose secretory dynamics .
9272106	0	cortisol	57,65	ACTH	28,32	cortisol	ACTH	MESH:D006854	5443	Chemical	Gene	response|amod|START_ENTITY cause|dobj|response dose|acl|cause dose|amod|END_ENTITY	One microgram is the lowest ACTH dose to cause a maximal cortisol response .
9272106	1	cortisol	109,117	ACTH	141,145	cortisol	ACTH	MESH:D006854	5443	Chemical	Gene	response|amod|START_ENTITY variation|nmod|response variation|acl|submaximal submaximal|dobj|stimulation stimulation|amod|END_ENTITY	There is no diurnal variation of cortisol response to submaximal ACTH stimulation .
12697678	7	cortisol	1183,1191	AGRP	1175,1179	cortisol	AGRP	MESH:D006854	181	Chemical	Gene	release|amod|START_ENTITY END_ENTITY|nmod|release	There was a significant stimulatory effect of 20 microg AGRP on cortisol release over time -LRB- P < 0.001 -RRB- .
15544862	0	cortisol	74,82	Agouti_Related_Protein	31,53	cortisol	Agouti Related Protein	MESH:D006854	782203(Tax:9913)	Chemical	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	Sustained inhibitory effect of Agouti_Related_Protein on the ACTH-induced cortisol production by bovine cultured adrenal cells .
9688669	0	cortisol	50,58	Angiotensin_II	0,14	cortisol	Angiotensin II	MESH:D006854	183	Chemical	Gene	secretion|amod|START_ENTITY modulate|dobj|secretion modulate|nsubj|infusion infusion|compound|END_ENTITY	Angiotensin_II infusion in vivo does not modulate cortisol secretion in the late-gestation ovine fetus .
21797816	0	cortisol	49,57	CB1	0,3	cortisol	CB1	MESH:D006854	1268	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|dep|effects	CB1 - cannabinoid receptor antagonist effects on cortisol in cannabis-dependent men .
24654784	0	cortisol	32,40	CBR1	75,79	cortisol	CBR1	MESH:D006854	873	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Induction of PGF2a synthesis by cortisol through GR dependent induction of CBR1 in human amnion fibroblasts .
18477503	0	cortisol	38,46	CCR2	50,54	cortisol	CCR2	MESH:D006854	729230	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|compound|END_ENTITY	The effects of acute exercise-induced cortisol on CCR2 expression on human monocytes .
21519909	0	cortisol	9,17	CPAP	60,64	cortisol	CPAP	MESH:D006854	55835	Chemical	Gene	effect|dep|START_ENTITY effect|nmod|END_ENTITY	Salivary cortisol in obstructive_sleep_apnea : the effect of CPAP .
22259060	0	cortisol	29,37	CRH	45,48	cortisol	CRH	MESH:D006854	1392	Chemical	Gene	START_ENTITY|nmod|stimulation stimulation|compound|END_ENTITY	Diagnostic value of salivary cortisol in the CRH stimulation test in premature infants .
21054475	0	cortisol	42,50	Corticosteroid-binding_globulin	0,31	cortisol	Corticosteroid-binding globulin	MESH:D006854	866	Chemical	Gene	pharmacokinetics|amod|START_ENTITY regulates|dobj|pharmacokinetics regulates|nsubj|END_ENTITY	Corticosteroid-binding_globulin regulates cortisol pharmacokinetics .
26522460	0	cortisol	77,85	Corticosteroid-binding_globulin	0,31	cortisol	Corticosteroid-binding globulin	MESH:D006854	866	Chemical	Gene	mechanisms|nmod|START_ENTITY END_ENTITY|dep|mechanisms	Corticosteroid-binding_globulin : Modulating mechanisms of bioavailability of cortisol and its clinical implications .
26522656	0	cortisol	118,126	Corticosteroid-binding_globulin	0,31	cortisol	Corticosteroid-binding globulin	MESH:D006854	866	Chemical	Gene	homeostasis|amod|START_ENTITY Implications|nmod|homeostasis deficiency|dep|Implications reduced|nmod|deficiency reduced|nsubjpass|cleavage cleavage|amod|END_ENTITY	Corticosteroid-binding_globulin cleavage is paradoxically reduced in alpha-1_antitrypsin deficiency : Implications for cortisol homeostasis .
7883828	0	cortisol	42,50	Corticosteroid-binding_globulin	0,31	cortisol	Corticosteroid-binding globulin	MESH:D006854	866	Chemical	Gene	responses|amod|START_ENTITY modulates|dobj|responses modulates|nsubj|END_ENTITY	Corticosteroid-binding_globulin modulates cortisol concentration responses to a given production rate .
7883829	0	cortisol	72,80	Corticosteroid-binding_globulin	0,31	cortisol	Corticosteroid-binding globulin	MESH:D006854	866	Chemical	Gene	transport|amod|START_ENTITY parameters|nmod|transport influences|dobj|parameters influences|nsubj|END_ENTITY	Corticosteroid-binding_globulin influences kinetic parameters of plasma cortisol transport and clearance .
15494460	0	cortisol	52,60	Corticotropin-releasing_hormone	0,31	cortisol	Corticotropin-releasing hormone	MESH:D006854	1392	Chemical	Gene	stimulates|dobj|START_ENTITY stimulates|nsubj|END_ENTITY	Corticotropin-releasing_hormone directly stimulates cortisol and the cortisol biosynthetic pathway in human fetal adrenal cells .
23131710	0	cortisol	84,92	Corticotropin-releasing_hormone	0,31	cortisol	Corticotropin-releasing hormone	MESH:D006854	1392	Chemical	Gene	reactivity|amod|START_ENTITY associated|nmod|reactivity associated|nsubjpass|polymorphisms polymorphisms|amod|END_ENTITY	Corticotropin-releasing_hormone system polymorphisms are associated with children 's cortisol reactivity .
3897382	0	cortisol	59,67	Fab	88,91	cortisol	Fab	MESH:D006854	2187	Chemical	Gene	START_ENTITY|nmod|serum serum|nmod|END_ENTITY	Homogeneous colorimetric enzyme inhibition immunoassay for cortisol in human serum with Fab anti-glucose_6-phosphate_dehydrogenase as a label modulator .
16237393	0	cortisol	93,101	GH	109,111	cortisol	GH	MESH:D006854	2688	Chemical	Gene	ghrelin|compound|START_ENTITY ghrelin|dep|END_ENTITY	Changes of sleep architecture , spectral composition of sleep EEG , the nocturnal secretion of cortisol , ACTH , GH , prolactin , melatonin , ghrelin , and leptin , and the DEX-CRH test in depressed patients during treatment with mirtazapine .
23125313	0	cortisol	55,63	GR	15,17	cortisol	GR	MESH:D006854	2908	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of GR and p300 in the induction of H6PD by cortisol in human amnion fibroblasts .
11383482	0	cortisol	75,83	Growth_hormone	0,14	cortisol	Growth hormone	MESH:D006854	2688	Chemical	Gene	withdrawal|amod|START_ENTITY effects|nmod|withdrawal secretion|dep|effects secretion|amod|END_ENTITY	Growth_hormone -LRB- GH -RRB- secretion in primary adrenal_insufficiency : effects of cortisol withdrawal and patterned replacement on GH pulsatility and circadian rhythmicity .
1153877	0	cortisol	67,75	Growth_hormone	0,14	cortisol	Growth hormone	MESH:D006854	81668(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY mitochondrial|dobj|effect mitochondrial|nsubj|END_ENTITY	Growth_hormone and liver mitochondrial protein synthesis effect of cortisol and estradiol .
8796136	0	cortisol	82,90	Growth_hormone	0,14	cortisol	Growth hormone	MESH:D006854	2688	Chemical	Gene	levels|amod|START_ENTITY circulating|dobj|levels reduces|xcomp|circulating reduces|nsubj|treatment treatment|amod|END_ENTITY	Growth_hormone treatment in hypopituitary_GH_deficient adults reduces circulating cortisol levels during hydrocortisone replacement therapy .
23125313	0	cortisol	55,63	H6PD	47,51	cortisol	H6PD	MESH:D006854	9563	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|induction induction|nmod|END_ENTITY	Involvement of GR and p300 in the induction of H6PD by cortisol in human amnion fibroblasts .
1185403	0	cortisol	22,30	Insulin	0,7	cortisol	Insulin	MESH:D006854	100009181(Tax:9986)	Chemical	Gene	action|amod|START_ENTITY antagonism|nmod|action antagonism|compound|END_ENTITY	Insulin antagonism of cortisol action on lechithin synthesis by cultured fetal lung cells .
12401942	0	cortisol	48,56	Insulin	0,7	cortisol	Insulin	MESH:D006854	3630	Chemical	Gene	plasma|amod|START_ENTITY relation|nmod|plasma resistance|nmod|relation resistance|compound|END_ENTITY	Insulin resistance -LRB- HOMA -RRB- in relation to plasma cortisol , IGF-I and IGFBP-3 .
2170767	0	cortisol	45,53	Insulin-like_growth_factor_I	0,28	cortisol	Insulin-like growth factor I	MESH:D006854	104978413	Chemical	Gene	production|amod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Insulin-like_growth_factor_I -LRB- IGF_I -RRB- induces cortisol production in bovine adrenocortical cells in primary culture .
10692140	0	cortisol	57,65	Interleukin-3	0,13	cortisol	Interleukin-3	MESH:D006854	280823(Tax:9913)	Chemical	Gene	secretion|amod|START_ENTITY stimulate|dobj|secretion stimulate|nsubj|END_ENTITY	Interleukin-3 and interleukin-6 stimulate bovine adrenal cortisol secretion through different pathways .
9112422	0	cortisol	42,50	Interleukin-3	0,13	cortisol	Interleukin-3	MESH:D006854	3562	Chemical	Gene	secretion|amod|START_ENTITY stimulate|dobj|secretion stimulate|nsubj|END_ENTITY	Interleukin-3 and interleukin-6 stimulate cortisol secretion from adult human adrenocortical cells .
18055157	0	cortisol	24,32	Interleukin-4	0,13	cortisol	Interleukin-4	MESH:D006854	280824(Tax:9913)	Chemical	Gene	release|amod|START_ENTITY increases|dobj|release increases|nsubj|END_ENTITY	Interleukin-4 increases cortisol release and decreases adrenal androgen release from bovine adrenal cells .
11824511	0	cortisol	16,24	Leptin	0,6	cortisol	Leptin	MESH:D006854	3952	Chemical	Gene	secretion|amod|START_ENTITY inhibits|dobj|secretion inhibits|nsubj|END_ENTITY	Leptin inhibits cortisol and corticosterone secretion in pathologic human adrenocortical cells .
26383480	0	cortisol	19,27	Oxytocin	0,8	cortisol	Oxytocin	MESH:D006854	5020	Chemical	Gene	increases|xcomp|START_ENTITY increases|nsubj|END_ENTITY	Oxytocin increases cortisol in men exposed to acute social-evaluative stress .
17220632	0	cortisol	88,96	POMC	64,68	cortisol	POMC	MESH:D006854	5443	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Steroid-dependent ACTH-produced thymic carcinoid : regulation of POMC gene expression by cortisol via methylation of its promoter region .
9530123	0	cortisol	63,71	POMC	47,51	cortisol	POMC	MESH:D006854	443212(Tax:9940)	Chemical	Gene	administration|amod|START_ENTITY END_ENTITY|nmod|administration	Divergent changes in plasma ACTH and pituitary POMC mRNA after cortisol administration to late-gestation ovine fetus .
21872610	0	cortisol	86,94	Parathyroid_hormone-related_protein	0,35	cortisol	Parathyroid hormone-related protein	MESH:D006854	19227(Tax:10090)	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Parathyroid_hormone-related_protein and glucocorticoid receptor beta are regulated by cortisol in the kidney of male mice .
6845060	0	cortisol	11,19	Prolactin	0,9	cortisol	Prolactin	MESH:D006854	5617	Chemical	Gene	levels|amod|START_ENTITY END_ENTITY|appos|levels	Prolactin , cortisol and thyroxine levels and the premature infant .
16497334	0	cortisol	72,80	Resistin	0,8	cortisol	Resistin	MESH:D006854	56729	Chemical	Gene	association|nmod|START_ENTITY END_ENTITY|dep|association	Resistin and adiponectin in major depression : the association with free cortisol and effects of antidepressant treatment .
26681828	0	cortisol	36,44	Salivary_alpha_amylase	0,22	cortisol	Salivary alpha amylase	MESH:D006854	276	Chemical	Gene	response|amod|START_ENTITY END_ENTITY|dobj|response	Salivary_alpha_amylase and salivary cortisol response to fluid consumption in exercising athletes .
16918948	7	cortisol	1266,1274	TNF-alpha	1320,1329	cortisol	TNF-alpha	MESH:D006854	7124	Chemical	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	In partial correlation analyses , significant associations were found : glycaemic level -LRB- HbA1c -RRB- with insulin resistance , TNF-alpha , CRP and basal and ACTH-stimulated cortisol levels , insulin resistance with plasma NEFA , TNF-alpha and stimulated cortisol levels .
190254	0	cortisol	16,24	TRF	38,41	cortisol	TRF	MESH:D006854	7200	Chemical	Gene	responses|amod|START_ENTITY responses|nmod|END_ENTITY	Plasma ACTH and cortisol responses to TRF , vasopressin or hypoglycemia in cushing 's _ disease and nelson 's _ syndrome .
21475800	0	cortisol	118,126	Vasopressin	0,11	cortisol	Vasopressin	MESH:D006854	551	Chemical	Gene	secretion|nmod|START_ENTITY spite|nmod|secretion have|nmod|spite have|nsubj|responders responders|compound|END_ENTITY	Vasopressin responders have a high prevalence of hypertension and insulin resistance in spite of a lower secretion of cortisol in subclinical Cushing 's _ syndrome .
7684742	0	cortisol	23,31	Vasopressin	0,11	cortisol	Vasopressin	MESH:D006854	551	Chemical	Gene	secretion|amod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Vasopressin stimulates cortisol secretion from human adrenocortical tissue through activation of V1 receptors .
1355636	0	cortisol	49,57	adrenocorticotropic_hormone	20,47	cortisol	adrenocorticotropic hormone	MESH:D006854	5443	Chemical	Gene	START_ENTITY|nsubj|Responses Responses|nmod|END_ENTITY	Responses of plasma adrenocorticotropic_hormone , cortisol , and cytokines during and after upper abdominal surgery .
23022993	0	cortisol	81,89	adrenocorticotropic_hormone	27,54	cortisol	adrenocorticotropic hormone	MESH:D006854	5443	Chemical	Gene	secretion|amod|START_ENTITY secretion|amod|END_ENTITY	Elevated cortisol inhibits adrenocorticotropic_hormone - and serotonin-stimulated cortisol secretion from the interrenal cells of the Gulf toadfish -LRB- Opsanus beta -RRB- .
23022993	0	cortisol	9,17	adrenocorticotropic_hormone	27,54	cortisol	adrenocorticotropic hormone	MESH:D006854	5443	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|amod|END_ENTITY	Elevated cortisol inhibits adrenocorticotropic_hormone - and serotonin-stimulated cortisol secretion from the interrenal cells of the Gulf toadfish -LRB- Opsanus beta -RRB- .
8730111	0	cortisol	58,66	adrenocorticotropic_hormone	7,34	cortisol	adrenocorticotropic hormone	MESH:D006854	5443	Chemical	Gene	response|amod|START_ENTITY END_ENTITY|dobj|response	Intact adrenocorticotropic_hormone secretion but impaired cortisol response in patients with active rheumatoid_arthritis .
21104582	0	cortisol	103,111	agouti-related_peptide	45,67	cortisol	agouti-related peptide	MESH:D006854	25582(Tax:10116)	Chemical	Gene	alterations|nmod|START_ENTITY alterations|nmod|END_ENTITY	Time-course alterations of plasma and soleus agouti-related_peptide and relationship to ATP , glycogen , cortisol , and insulin concentrations following treadmill training programs in male rats .
217621	0	cortisol	62,70	angiotensin_II	11,25	cortisol	angiotensin II	MESH:D006854	183	Chemical	Gene	secretion|amod|START_ENTITY inhibit|dobj|secretion Failure|acl|inhibit Failure|nmod|END_ENTITY	Failure of angiotensin_II to inhibit corticotropin-stimulated cortisol secretion .
3041145	0	cortisol	73,81	angiotensin_II	40,54	cortisol	angiotensin II	MESH:D006854	183	Chemical	Gene	release|nmod|START_ENTITY END_ENTITY|nmod|release	Evidence for the direct intervention of angiotensin_II in the release of cortisol in teleost fishes .
12152842	0	cortisol	64,72	arginine-vasopressin	21,41	cortisol	arginine-vasopressin	MESH:D006854	551	Chemical	Gene	response|amod|START_ENTITY compare|nmod|response compare|nsubj|response response|nmod|END_ENTITY	Cortisol response to arginine-vasopressin does not compare with cortisol response to insulin-hypoglycemia in pituitary_tumors .
15273434	0	cortisol	61,69	cardiac_troponin_I	6,24	cortisol	cardiac troponin I	MESH:D006854	7137	Chemical	Gene	related|nmod|START_ENTITY related|nsubjpass|END_ENTITY	Serum cardiac_troponin_I in acute_stroke is related to serum cortisol and TNF-alpha .
10950824	0	cortisol	65,73	connective_tissue_growth_factor	30,61	cortisol	connective tissue growth factor	MESH:D006854	64032(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of connective_tissue_growth_factor by cortisol in osteoblasts .
10978730	0	cortisol	76,84	corticosteroid-binding_globulin	16,47	cortisol	corticosteroid-binding globulin	MESH:D006854	866	Chemical	Gene	START_ENTITY|nsubj|levels levels|nmod|cortisol cortisol|amod|END_ENTITY	Blood levels of corticosteroid-binding_globulin , total cortisol and unbound cortisol in patients undergoing coronary artery bypass grafting surgery with cardiopulmonary bypass .
15904907	0	cortisol	12,20	corticosteroid-binding_globulin	61,92	cortisol	corticosteroid-binding globulin	MESH:D006854	866	Chemical	Gene	fraction|amod|START_ENTITY reflects|nsubj|fraction reflects|dobj|levels levels|nmod|END_ENTITY	Plasma free cortisol fraction reflects levels of functioning corticosteroid-binding_globulin .
16702435	0	cortisol	152,160	corticosteroid-binding_globulin	55,86	cortisol	corticosteroid-binding globulin	MESH:D006854	396736(Tax:9823)	Chemical	Gene	variability|amod|START_ENTITY associated|nmod|variability locus|dep|associated locus|nsubj|implication implication|nmod|substitution substitution|nmod|END_ENTITY	Functional implication of an Arg307Gly substitution in corticosteroid-binding_globulin , a candidate gene for a quantitative trait locus associated with cortisol variability and obesity in pig .
17526821	0	cortisol	88,96	corticosteroid-binding_globulin	30,61	cortisol	corticosteroid-binding globulin	MESH:D006854	866	Chemical	Gene	decreases|dobj|START_ENTITY decreases|iobj|levels levels|amod|END_ENTITY	Massive weight_loss decreases corticosteroid-binding_globulin levels and increases free cortisol in healthy_obese patients : an adaptive phenomenon ?
2370299	0	cortisol	58,66	corticosteroid-binding_globulin	11,42	cortisol	corticosteroid-binding globulin	MESH:D006854	866	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A role for corticosteroid-binding_globulin in delivery of cortisol to activated neutrophils .
23783094	0	cortisol	73,81	corticosteroid-binding_globulin	27,58	cortisol	corticosteroid-binding globulin	MESH:D006854	866	Chemical	Gene	concentration|amod|START_ENTITY modulate|dobj|concentration modulate|nsubj|changes changes|nmod|affinity affinity|nmod|END_ENTITY	How changes in affinity of corticosteroid-binding_globulin modulate free cortisol concentration .
2394772	0	cortisol	34,42	corticosteroid-binding_globulin	93,124	cortisol	corticosteroid-binding globulin	MESH:D006854	866	Chemical	Gene	levels|compound|START_ENTITY increase|nmod|levels due|nsubj|increase due|nmod|increase increase|nmod|levels levels|amod|END_ENTITY	The increase in plasma and saliva cortisol levels in pregnancy is not due to the increase in corticosteroid-binding_globulin levels .
24424442	0	cortisol	91,99	corticosteroid-binding_globulin	28,59	cortisol	corticosteroid-binding globulin	MESH:D006854	866	Chemical	Gene	release|amod|START_ENTITY target|nmod|release target|nsubj|reactive_centre_loop reactive_centre_loop|nmod|END_ENTITY	The reactive_centre_loop of corticosteroid-binding_globulin -LRB- CBG -RRB- is a protease target for cortisol release .
26302113	0	cortisol	4,12	corticosteroid-binding_globulin	69,100	cortisol	corticosteroid-binding globulin	MESH:D006854	396736(Tax:9823)	Chemical	Gene	response|amod|START_ENTITY response|nmod|END_ENTITY	The cortisol response to ACTH in pigs , heritability and influence of corticosteroid-binding_globulin .
6738767	1	cortisol	58,66	corticosteroid-binding_globulin	98,129	cortisol	corticosteroid-binding globulin	MESH:D006854	866	Chemical	Gene	Absence|nmod|START_ENTITY binding|nsubj|Absence binding|xcomp|cortisol cortisol|xcomp|binding binding|nmod|END_ENTITY	I. Absence of abnormal cortisol binding to cortisol binding to corticosteroid-binding_globulin .
6738767	1	cortisol	78,86	corticosteroid-binding_globulin	98,129	cortisol	corticosteroid-binding globulin	MESH:D006854	866	Chemical	Gene	START_ENTITY|xcomp|binding binding|nmod|END_ENTITY	I. Absence of abnormal cortisol binding to cortisol binding to corticosteroid-binding_globulin .
3026693	0	cortisol	43,51	corticotrophin-releasing_hormone	67,99	cortisol	corticotrophin-releasing hormone	MESH:D006854	1392	Chemical	Gene	suppression|amod|START_ENTITY suppression|nmod|END_ENTITY	Escape from dexamethasone-induced ACTH and cortisol suppression by corticotrophin-releasing_hormone : modulatory effect of basal dexamethasone levels .
11555839	0	cortisol	99,107	corticotropin-releasing_hormone	47,78	cortisol	corticotropin-releasing hormone	MESH:D006854	1392	Chemical	Gene	secretion|amod|START_ENTITY polymorphism|nmod|secretion polymorphism|nmod|region region|nmod|gene gene|amod|END_ENTITY	A polymorphism in the regulatory region of the corticotropin-releasing_hormone gene in relation to cortisol secretion , obesity , and gene-gene interaction .
1314020	0	cortisol	77,85	corticotropin-releasing_hormone	42,73	cortisol	corticotropin-releasing hormone	MESH:D006854	1392	Chemical	Gene	release|amod|START_ENTITY END_ENTITY|nmod|release	Corticotropin-independent effect of ovine corticotropin-releasing_hormone on cortisol release in man .
1331166	0	cortisol	105,113	corticotropin-releasing_hormone	16,47	cortisol	corticotropin-releasing hormone	MESH:D006854	1392	Chemical	Gene	response|compound|START_ENTITY suppression|nmod|response prevents|dobj|suppression prevents|nsubj|END_ENTITY	Pulsatile human corticotropin-releasing_hormone prevents dexamethasone-induced suppression of the plasma cortisol response to hypoglycemia in normal men .
1464659	0	cortisol	16,24	corticotropin-releasing_hormone	44,75	cortisol	corticotropin-releasing hormone	MESH:D006854	1392	Chemical	Gene	responses|amod|START_ENTITY Heritability|nmod|responses Heritability|nmod|END_ENTITY	Heritability of cortisol responses to human corticotropin-releasing_hormone , ergometry , and psychological stress in humans .
15677424	0	cortisol	54,62	corticotropin-releasing_hormone	76,107	cortisol	corticotropin-releasing hormone	MESH:D006854	1392	Chemical	Gene	responses|amod|START_ENTITY characterize|dobj|responses characterize|nmod|challenge challenge|amod|END_ENTITY	Applying a nonlinear regression model to characterize cortisol responses to corticotropin-releasing_hormone challenge .
16103684	0	cortisol	79,87	corticotropin-releasing_hormone	33,64	cortisol	corticotropin-releasing hormone	MESH:D006854	1392	Chemical	Gene	measurement|amod|START_ENTITY response|dep|measurement response|nmod|END_ENTITY	Adrenocortical response to ovine corticotropin-releasing_hormone in young men : cortisol measurement in matched samples of saliva and plasma .
1851183	0	cortisol	107,115	corticotropin-releasing_hormone	51,82	cortisol	corticotropin-releasing hormone	MESH:D006854	1392	Chemical	Gene	pulsatile|nmod|START_ENTITY pulsatile|dobj|END_ENTITY	Dose-response effects of exogenous pulsatile human corticotropin-releasing_hormone on adrenocorticotropin , cortisol , and gonadotropin concentrations in agonadal women .
2065137	0	cortisol	21,29	corticotropin-releasing_hormone	48,79	cortisol	corticotropin-releasing hormone	MESH:D006854	1392	Chemical	Gene	response|amod|START_ENTITY response|nmod|END_ENTITY	Effect of age on the cortisol response to human corticotropin-releasing_hormone in depressed patients pretreated with dexamethasone .
21494051	0	cortisol	64,72	corticotropin-releasing_hormone	114,145	cortisol	corticotropin-releasing hormone	MESH:D006854	1392	Chemical	Gene	responses|amod|START_ENTITY blunted|dobj|responses blunted|nmod|test test|compound|END_ENTITY	Schizotypal_personality in healthy adults is related to blunted cortisol responses to the combined dexamethasone / corticotropin-releasing_hormone test .
2153693	0	cortisol	9,17	corticotropin-releasing_hormone	45,76	cortisol	corticotropin-releasing hormone	MESH:D006854	1392	Chemical	Gene	secretion|amod|START_ENTITY Abnormal|dobj|secretion Abnormal|xcomp|END_ENTITY	Abnormal cortisol secretion and responses to corticotropin-releasing_hormone in women with hypothalamic amenorrhea .
23896353	0	cortisol	86,94	corticotropin-releasing_hormone	44,75	cortisol	corticotropin-releasing hormone	MESH:D006854	1392	Chemical	Gene	administration|amod|START_ENTITY END_ENTITY|nmod|administration	No acute suppression of cerebrospinal fluid corticotropin-releasing_hormone in man by cortisol administration .
26500680	0	cortisol	5,13	corticotropin-releasing_hormone	26,57	cortisol	corticotropin-releasing hormone	MESH:D006854	1392	Chemical	Gene	response|amod|START_ENTITY response|nmod|END_ENTITY	Peak cortisol response to corticotropin-releasing_hormone is associated with age and body size in children referred for clinical testing : a retrospective review .
3007554	0	cortisol	142,150	corticotropin-releasing_hormone	34,65	cortisol	corticotropin-releasing hormone	MESH:D006854	1392	Chemical	Gene	pattern|amod|START_ENTITY restoration|nmod|pattern administration|dep|restoration administration|nmod|END_ENTITY	Pulsatile administration of human corticotropin-releasing_hormone in patients with secondary_adrenal_insufficiency : restoration of the normal cortisol secretory pattern .
8393777	0	cortisol	36,44	corticotropin-releasing_hormone	65,96	cortisol	corticotropin-releasing hormone	MESH:D006854	100063840(Tax:9796)	Chemical	Gene	lowering|dobj|START_ENTITY lowering|nmod|secretion secretion|nmod|END_ENTITY	The acute effect of lowering plasma cortisol on the secretion of corticotropin-releasing_hormone , arginine_vasopressin , and adrenocorticotropin as revealed by intensive sampling of pituitary venous blood in the normal horse .
8888355	0	cortisol	52,60	corticotropin-releasing_hormone	11,42	cortisol	corticotropin-releasing hormone	MESH:D006854	1392	Chemical	Gene	Effects|amod|START_ENTITY Effects|nmod|END_ENTITY	Effects of corticotropin-releasing_hormone on ACTH , cortisol and 13 , _ 14-dihydro-15-keto_prostaglandin_E2 in patients with diabetes_insipidus before and after captopril treatment .
2359762	0	cortisol	117,125	corticotropin_releasing_factor	26,56	cortisol	corticotropin releasing factor	MESH:D006854	100127468(Tax:9823)	Chemical	Gene	effects|nmod|START_ENTITY administration|dep|effects administration|nmod|END_ENTITY	Central administration of corticotropin_releasing_factor in the pig : effects on operant feeding , drinking and plasma cortisol .
19837932	0	cortisol	96,104	cyclooxygenase-2	108,124	cortisol	cyclooxygenase-2	MESH:D006854	5743	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|expression expression|amod|END_ENTITY	Expression of progesterone receptor A form and its role in the interaction of progesterone with cortisol on cyclooxygenase-2 expression in amnionic fibroblasts .
20888580	0	cortisol	62,70	ghrelin	11,18	cortisol	ghrelin	MESH:D006854	58991(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of ghrelin on psychopathology , sleep and secretion of cortisol and growth_hormone in patients with major_depression .
18248637	0	cortisol	25,33	glucocorticoid_receptor	126,149	cortisol	glucocorticoid receptor	MESH:D006854	2908	Chemical	Gene	relationship|nmod|START_ENTITY relationship|nmod|END_ENTITY	The relationship between cortisol , muscle mass and muscle strength in older persons and the role of genetic variations in the glucocorticoid_receptor .
24785104	1	cortisol	27,35	glucocorticoid_receptor	71,94	cortisol	glucocorticoid receptor	MESH:D006854	2908	Chemical	Gene	stimulate|nsubj|START_ENTITY stimulate|nmod|END_ENTITY	Can cortisol stimulate adipogenesis without the glucocorticoid_receptor ?
8574285	0	cortisol	66,74	glucocorticoid_receptor	34,57	cortisol	glucocorticoid receptor	MESH:D006854	2908	Chemical	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	Differences in down-regulation of glucocorticoid_receptor mRNA by cortisol , prednisolone and dexamethasone in HeLa cells .
1296456	0	cortisol	63,71	granulocyte-macrophage_colony_stimulating_factor	11,59	cortisol	granulocyte-macrophage colony stimulating factor	MESH:D006854	1437	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of granulocyte-macrophage_colony_stimulating_factor on cortisol , growth_hormone , prolactin and melatonin in cancer patients -LRB- short communication -RRB- .
10607111	0	cortisol	21,29	growth_hormone	66,80	cortisol	growth hormone	MESH:D006854	2688	Chemical	Gene	infusion|amod|START_ENTITY infusion|nmod|END_ENTITY	Effects of pulsatile cortisol infusion on sleep-EEG and nocturnal growth_hormone release in healthy men .
10653218	0	cortisol	29,37	growth_hormone	72,86	cortisol	growth hormone	MESH:D006854	2688	Chemical	Gene	secretion|amod|START_ENTITY inhibitor|nmod|secretion inhibitor|acl:relcl|influence influence|dobj|secretion secretion|compound|END_ENTITY	Mirtazapine : an inhibitor of cortisol secretion that does not influence growth_hormone and prolactin secretion .
10770221	0	cortisol	14,22	growth_hormone	46,60	cortisol	growth hormone	MESH:D006854	2688	Chemical	Gene	metabolism|amod|START_ENTITY Modulation|nmod|metabolism Modulation|nmod|replacement replacement|compound|END_ENTITY	Modulation of cortisol metabolism by low-dose growth_hormone replacement in elderly hypopituitary patients .
11124860	0	cortisol	59,67	growth_hormone	11,25	cortisol	growth hormone	MESH:D006854	2688	Chemical	Gene	globulin|amod|START_ENTITY levels|nmod|globulin therapy|nmod|levels therapy|amod|END_ENTITY	Effects of growth_hormone replacement therapy on levels of cortisol and cortisol-binding globulin in hypopituitary adults .
11465341	0	cortisol	41,49	growth_hormone	11,25	cortisol	growth hormone	MESH:D006854	2688	Chemical	Gene	metabolism|amod|START_ENTITY replacement|nmod|metabolism replacement|amod|END_ENTITY	Effects of growth_hormone replacement on cortisol metabolism in hypopituitary patients treated with cortisone_acetate .
1173985	0	cortisol	55,63	growth_hormone	29,43	cortisol	growth hormone	MESH:D006854	2688	Chemical	Gene	START_ENTITY|nsubj|study study|nmod|END_ENTITY	A comparative study of serum growth_hormone and plasma cortisol levels in stimulation tests with insulin and propranolol-glucagon .
15365655	0	cortisol	100,108	growth_hormone	11,25	cortisol	growth hormone	MESH:D006854	2688	Chemical	Gene	ratio|amod|START_ENTITY deficiency|nmod|ratio deficiency|amod|END_ENTITY	Effects of growth_hormone deficiency and rhGH replacement therapy on the 6beta-hydroxycortisol/free cortisol ratio , a marker of CYP3A activity , in growth_hormone-deficient children .
17003023	0	cortisol	23,31	growth_hormone	42,56	cortisol	growth hormone	MESH:D006854	2688	Chemical	Gene	levels|amod|START_ENTITY levels|nmod|END_ENTITY	The influence of serum cortisol levels on growth_hormone responsiveness to GH-releasing hormone plus GH-releasing peptide-6 in patients with hypocortisolism .
3117958	0	cortisol	93,101	growth_hormone	34,48	cortisol	growth hormone	MESH:D006854	2688	Chemical	Gene	somatotrophinomas|nmod|START_ENTITY secretion|nmod|somatotrophinomas secretion|nsubj|maintenance maintenance|nmod|END_ENTITY	Long-term in-vitro maintenance of growth_hormone secretion from human somatotrophinomas with cortisol , and its effects on growth_hormone-releasing factor .
7364929	0	cortisol	15,23	growth_hormone	43,57	cortisol	growth hormone	MESH:D006854	2688	Chemical	Gene	secretion|amod|START_ENTITY Suppression|nmod|secretion Suppression|nmod|END_ENTITY	Suppression of cortisol secretion by human growth_hormone .
7486404	0	cortisol	22,30	growth_hormone	91,105	cortisol	growth hormone	MESH:D006854	443329(Tax:9940)	Chemical	Gene	infusion|amod|START_ENTITY Effects|nmod|infusion Effects|nmod|release release|amod|END_ENTITY	Effects of short-term cortisol infusion on growth_hormone-releasing_hormone stimulation of growth_hormone release in sheep .
7673652	0	cortisol	110,118	growth_hormone	56,70	cortisol	growth hormone	MESH:D006854	2688	Chemical	Gene	effect|nmod|START_ENTITY Loss|dep|effect Loss|nmod|variation variation|nmod|responses responses|compound|END_ENTITY	Loss of the diurnal variation of pyridostigmine-induced growth_hormone responses in depression : the effect of cortisol .
7828353	0	cortisol	44,52	growth_hormone	14,28	cortisol	growth hormone	MESH:D006854	2688	Chemical	Gene	metabolism|amod|START_ENTITY effect|nmod|metabolism effect|nmod|replacement replacement|amod|END_ENTITY	The effect of growth_hormone replacement on cortisol metabolism and glucocorticoid sensitivity in hypopituitary adults .
7830002	0	cortisol	160,168	growth_hormone	131,145	cortisol	growth hormone	MESH:D006854	403795(Tax:9615)	Chemical	Gene	insulin|dep|START_ENTITY insulin|compound|END_ENTITY	Effects of acute and repeated intravenous administration of L-692 ,585 , a novel non-peptidyl growth_hormone secretagogue , on plasma growth_hormone , IGF-1 , ACTH , cortisol , prolactin , insulin , and thyroxine levels in beagles .
7976413	0	cortisol	9,17	growth_hormone	27,41	cortisol	growth hormone	MESH:D006854	2688	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|response response|amod|END_ENTITY	Lowering cortisol enhances growth_hormone response to growth_hormone_releasing_hormone in healthy subjects .
8738113	0	cortisol	80,88	growth_hormone	7,21	cortisol	growth hormone	MESH:D006854	2688	Chemical	Gene	concentration|compound|START_ENTITY rise|nmod|concentration regulated|nmod|rise regulated|nsubjpass|concentration concentration|amod|END_ENTITY	Is the growth_hormone concentration regulated by the morning rise in the plasma cortisol concentration ?
8818980	0	cortisol	70,78	growth_hormone	49,63	cortisol	growth hormone	MESH:D006854	2688	Chemical	Gene	arginine_vasopressin|amod|START_ENTITY arginine_vasopressin|appos|END_ENTITY	Replacement therapy : arginine_vasopressin -LRB- AVP -RRB- , growth_hormone -LRB- GH -RRB- , cortisol , thyroxine , testosterone and estrogen .
9826216	0	cortisol	41,49	growth_hormone	15,29	cortisol	growth hormone	MESH:D006854	2688	Chemical	Gene	production|amod|START_ENTITY suppresses|dobj|production suppresses|nsubj|Treatment Treatment|nmod|END_ENTITY	Treatment with growth_hormone suppresses cortisol production in man .
9828914	0	cortisol	25,33	growth_hormone	176,190	cortisol	growth hormone	MESH:D006854	2688	Chemical	Gene	changes|amod|START_ENTITY effect|nmod|changes effect|nmod|deficiency deficiency|compound|END_ENTITY	The effect of short-term cortisol changes on growth_hormone responses to the pyridostigmine-growth-hormone-releasing-hormone test in healthy adults and patients with suspected growth_hormone deficiency .
9828914	0	cortisol	25,33	growth_hormone	45,59	cortisol	growth hormone	MESH:D006854	2688	Chemical	Gene	changes|amod|START_ENTITY effect|nmod|changes effect|nmod|responses responses|amod|END_ENTITY	The effect of short-term cortisol changes on growth_hormone responses to the pyridostigmine-growth-hormone-releasing-hormone test in healthy adults and patients with suspected growth_hormone deficiency .
12505096	0	cortisol	55,63	insulin	16,23	cortisol	insulin	MESH:D006854	3630	Chemical	Gene	levels|amod|START_ENTITY Relationship|nmod|levels Relationship|nmod|resistance resistance|compound|END_ENTITY	Relationship of insulin resistance and overweight with cortisol and dehydroepiandrosterone-sulfate levels .
16918948	7	cortisol	1266,1274	insulin	1283,1290	cortisol	insulin	MESH:D006854	3630	Chemical	Gene	levels|amod|START_ENTITY levels|appos|resistance resistance|compound|END_ENTITY	In partial correlation analyses , significant associations were found : glycaemic level -LRB- HbA1c -RRB- with insulin resistance , TNF-alpha , CRP and basal and ACTH-stimulated cortisol levels , insulin resistance with plasma NEFA , TNF-alpha and stimulated cortisol levels .
2163473	0	cortisol	43,51	insulin	85,92	cortisol	insulin	MESH:D006854	280829(Tax:9913)	Chemical	Gene	modulation|nmod|START_ENTITY secretion|nsubj|modulation secretion|nmod|END_ENTITY	Differential modulation of ACTH-stimulated cortisol and androstenedione secretion by insulin .
26922819	7	cortisol	1371,1379	insulin	1407,1414	cortisol	insulin	MESH:D006854	3630	Chemical	Gene	rise|nmod|START_ENTITY cause|nsubj|rise cause|dobj|patients patients|amod|hyperglycemia hyperglycemia|nmod|END_ENTITY	We conclude that the diurnal morning rise in cortisol may cause hyperglycemia in insulin dependent diabetic patients if insufficient exogenous insulin remains and/or endogenous insulin is not secreted .
26934392	0	cortisol	22,30	insulin	58,65	cortisol	insulin	MESH:D006854	3630	Chemical	Gene	regeneration|nmod|START_ENTITY contributes|nsubj|regeneration contributes|nmod|resistance resistance|compound|END_ENTITY	Local regeneration of cortisol by 11b-HSD1 contributes to insulin resistance of the granulosa cells in PCOS .
3905208	0	cortisol	21,29	insulin	110,117	cortisol	insulin	MESH:D006854	3630	Chemical	Gene	Measurement|nmod|START_ENTITY Measurement|nmod|hypoglycaemia hypoglycaemia|compound|END_ENTITY	Measurement of blood cortisol and acid output in patients with duodenal ulceration and normal subjects during insulin hypoglycaemia .
8772471	0	cortisol	19,27	insulin	41,48	cortisol	insulin	MESH:D006854	3630	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Effects of morning cortisol elevation on insulin secretion and glucose regulation in humans .
9553119	0	cortisol	79,87	insulin-like_growth_factor-II	30,59	cortisol	insulin-like growth factor-II	MESH:D006854	443325(Tax:9940)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Transcriptional regulation of insulin-like_growth_factor-II gene expression by cortisol in fetal sheep during late gestation .
16424263	0	cortisol	92,100	interferon-gamma	111,127	cortisol	interferon-gamma	MESH:D006854	3458	Chemical	Gene	Effect|amod|START_ENTITY Effect|nmod|production production|amod|END_ENTITY	Effect of carprofen administration during banding or burdizzo castration of bulls on plasma cortisol , in vitro interferon-gamma production , acute-phase proteins , feed intake , and growth .
2548970	0	cortisol	16,24	interferon-gamma	39,55	cortisol	interferon-gamma	MESH:D006854	3458	Chemical	Gene	levels|amod|START_ENTITY plasma|dobj|levels plasma|nmod|treatment treatment|amod|END_ENTITY	Elevated plasma cortisol levels during interferon-gamma treatment .
9110218	0	cortisol	11,19	interferon-gamma	32,48	cortisol	interferon-gamma	MESH:D006854	281237(Tax:9913)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|production production|amod|END_ENTITY	Effects of cortisol on in vitro interferon-gamma production , acute-phase proteins , growth , and feed intake in a calf castration model .
9222848	0	cortisol	23,31	interferon-gamma	109,125	cortisol	interferon-gamma	MESH:D006854	281237(Tax:9913)	Chemical	Gene	castration|amod|START_ENTITY suppressing|dobj|castration suppressing|nmod|production production|amod|END_ENTITY	Effects of suppressing cortisol following castration of bull calves on adrenocorticotropic hormone , in vitro interferon-gamma production , leukocytes , acute-phase proteins , growth , and feed intake .
20466437	0	cortisol	58,66	interleukin-1beta	74,91	cortisol	interleukin-1beta	MESH:D006854	3553	Chemical	Gene	START_ENTITY|dobj|concentrations concentrations|amod|END_ENTITY	Effects of eicosapentaenoic_acid and fluoxetine on plasma cortisol , serum interleukin-1beta and interleukin-6 concentrations in patients with major depressive_disorder .
15577621	0	cortisol	94,102	interleukin-2	22,35	cortisol	interleukin-2	MESH:D006854	3558	Chemical	Gene	concentrations|compound|START_ENTITY correlated|nmod|concentrations correlated|nsubjpass|therapy therapy|compound|END_ENTITY	T-cell function after interleukin-2 therapy in HIV-infected patients is correlated with serum cortisol concentrations .
1666467	0	cortisol	93,101	interleukin-2	51,64	cortisol	interleukin-2	MESH:D006854	3558	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of prolonged subcutaneous administration of interleukin-2 on the circadian rhythms of cortisol and beta-endorphin in advanced small_cell_lung_cancer patients .
20807140	0	cortisol	155,163	interleukin-6	175,188	cortisol	interleukin-6	MESH:D006854	403985(Tax:9615)	Chemical	Gene	serum|xcomp|START_ENTITY serum|dobj|END_ENTITY	Comparison of the effects of tramadol , codeine , and ketoprofen alone or in combination on postoperative pain and on concentrations of blood glucose , serum cortisol , and serum interleukin-6 in dogs undergoing maxillectomy or mandibulectomy .
9496240	0	cortisol	11,19	interleukin-6	41,54	cortisol	interleukin-6	MESH:D006854	3569	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|acl|END_ENTITY	Effects of cortisol on the expression of interleukin-6 and interleukin-1_beta in human osteoblast-like cells .
11128893	0	cortisol	61,69	leptin	22,28	cortisol	leptin	MESH:D006854	3952	Chemical	Gene	START_ENTITY|nsubj|relation relation|nmod|END_ENTITY	The relation of serum leptin to body mass index and to serum cortisol in men with spinal_cord_injury .
7337289	0	cortisol	10,18	milk	62,66	cortisol	milk	MESH:D006854	100532204	Chemical	Gene	START_ENTITY|nmod|function function|nmod|END_ENTITY	Effect of cortisol on the bactericidal function of the bovine milk neutrophil in vitro .
15094794	0	cortisol	26,34	oxytocin	14,22	cortisol	oxytocin	MESH:D006854	100152272(Tax:9823)	Chemical	Gene	secretion|amod|START_ENTITY END_ENTITY|nmod|secretion	The effect of oxytocin on cortisol and corticosterone secretion in cyclic gilts -- in vivo and in vitro studies .
16046364	0	cortisol	48,56	oxytocin	38,46	cortisol	oxytocin	MESH:D006854	5020	Chemical	Gene	norepinephrine|dep|START_ENTITY norepinephrine|compound|END_ENTITY	Effects of partner support on resting oxytocin , cortisol , norepinephrine , and blood pressure before and after warm partner contact .
17267094	0	cortisol	79,87	oxytocin	57,65	cortisol	oxytocin	MESH:D006854	5020	Chemical	Gene	administration|amod|START_ENTITY predict|nmod|administration predict|dobj|responses responses|compound|END_ENTITY	Individual differences in emotional expressivity predict oxytocin responses to cortisol administration : relevance to breast_cancer ?
6457679	0	cortisol	67,75	oxytocin	36,44	cortisol	oxytocin	MESH:D006854	5020	Chemical	Gene	level|amod|START_ENTITY decrease|nmod|level induces|dobj|decrease induces|nsubj|injection injection|nmod|END_ENTITY	-LSB- Intravenous injection of synthetic oxytocin induces a decrease of cortisol plasma level in normal man -RSB- .
15279069	0	cortisol	37,45	peroxisome_proliferator-activated_receptor-gamma	81,129	cortisol	peroxisome proliferator-activated receptor-gamma	MESH:D006854	5468	Chemical	Gene	levels|amod|START_ENTITY levels|nmod|administration administration|nmod|END_ENTITY	Baseline and CRH-stimulated ACTH and cortisol levels after administration of the peroxisome_proliferator-activated_receptor-gamma ligand , rosiglitazone , in Cushing 's _ disease .
12680745	0	cortisol	90,98	prolactin	4,13	cortisol	prolactin	MESH:D006854	5617	Chemical	Gene	effects|nmod|START_ENTITY response|dep|effects response|amod|END_ENTITY	The prolactin response to fenfluramine in depression : effects of melancholia and baseline cortisol .
15833589	0	cortisol	11,19	prolactin	42,51	cortisol	prolactin	MESH:D006854	5617	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of cortisol and cocaine on plasma prolactin and growth_hormone levels in cocaine-dependent volunteers .
18484195	0	cortisol	112,120	prolactin	23,32	cortisol	prolactin	MESH:D006854	5617	Chemical	Gene	release|amod|START_ENTITY ACTH|nmod|release effects|nmod|ACTH effects|nmod|END_ENTITY	Comparative effects of prolactin versus ACTH , estradiol , progesterone , testosterone , and dihydrotestosterone on cortisol release and proliferation of the adrenocortical_carcinoma cell line H295R .
1938655	0	cortisol	25,33	prolactin	35,44	cortisol	prolactin	MESH:D006854	5617	Chemical	Gene	concentrations|nmod|START_ENTITY concentrations|acl|END_ENTITY	Plasma concentrations of cortisol , prolactin , luteinizing hormone , and follicle-stimulating hormone in stallions after physical exercise and injection of secretagogue before and after sulpiride treatment in winter .
3920651	0	cortisol	131,139	prolactin	28,37	cortisol	prolactin	MESH:D006854	24683(Tax:10116)	Chemical	Gene	-RSB-|amod|START_ENTITY administration|nmod|-RSB- Synthesis|nmod|administration Synthesis|nmod|END_ENTITY	-LSB- Synthesis and secretion of prolactin and growth_hormone in rats with protein-calorie_malnutrition and effect of administration of cortisol -RSB- .
6280425	0	cortisol	41,49	prolactin	69,78	cortisol	prolactin	MESH:D006854	5617	Chemical	Gene	secretion|amod|START_ENTITY effect|nmod|secretion suppressive|dobj|effect suppressive|nmod|levels levels|compound|END_ENTITY	Acute suppressive effect of ACTH-induced cortisol secretion on serum prolactin levels in healthy man .
6514937	0	cortisol	18,26	prolactin	42,51	cortisol	prolactin	MESH:D006854	5617	Chemical	Gene	secretion|amod|START_ENTITY secretion|compound|END_ENTITY	Morphine inhibits cortisol and stimulates prolactin secretion in man .
11444431	0	cortisol	11,19	proopiomelanocortin	61,80	cortisol	proopiomelanocortin	MESH:D006854	443212(Tax:9940)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effects of cortisol and estradiol on pituitary expression of proopiomelanocortin , prohormone convertase-1 , prohormone convertase-2 , and glucocorticoid receptor mRNA in fetal sheep .
21820043	0	cortisol	20,28	receptor_for_Activated_C_Kinase_1	81,114	cortisol	receptor for Activated C Kinase 1	MESH:D006854	10399	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Opposing effects of cortisol and dehydroepiandrosterone on the expression of the receptor_for_Activated_C_Kinase_1 : implications in immunosenescence .
15515576	0	cortisol	64,72	renin	7,12	cortisol	renin	MESH:D006854	101081695	Chemical	Gene	hormone|amod|START_ENTITY concentrations|nmod|hormone END_ENTITY|dobj|concentrations	Plasma renin activity and plasma concentrations of aldosterone , cortisol , adrenocorticotropic hormone , and alpha-melanocyte-stimulating hormone in healthy cats .
6362571	0	cortisol	63,71	renin	11,16	cortisol	renin	MESH:D006854	5972	Chemical	Gene	metabolism|amod|START_ENTITY disturbance|nmod|metabolism associated|nmod|disturbance hypertension|acl|associated hypertension|compound|END_ENTITY	Fatal , low renin hypertension associated with a disturbance of cortisol metabolism .
7784141	0	cortisol	30,38	renin	42,47	cortisol	renin	MESH:D006854	443310(Tax:9940)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effect of chronic infusion of cortisol on renin gene expression and renin response to hemorrhage in fetal lambs .
26706694	0	cortisol	8,16	serotonin_transporter	74,95	cortisol	serotonin transporter	MESH:D006854	6532	Chemical	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	Neither cortisol nor brain-derived_neurotrophic_factor is associated with serotonin_transporter in bipolar_disorder .
17003084	0	cortisol	48,56	surfactant_protein_A	13,33	cortisol	surfactant protein A	MESH:D006854	653509	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Induction of surfactant_protein_A expression by cortisol facilitates prostaglandin synthesis in human chorionic trophoblasts .
9165024	0	cortisol	44,52	tumor_necrosis_factor-alpha	117,144	cortisol	tumor necrosis factor-alpha	MESH:D006854	397086(Tax:9823)	Chemical	Gene	START_ENTITY|nmod|injection injection|nmod|END_ENTITY	Coincidental changes in behavior and plasma cortisol in unrestrained pigs after intracerebroventricular injection of tumor_necrosis_factor-alpha .
8080916	0	cortisol	165,173	tumor_necrosis_factor_alpha	195,222	cortisol	tumor necrosis factor alpha	MESH:D006854	443540(Tax:9940)	Chemical	Gene	concentrations|amod|START_ENTITY concentrations|compound|END_ENTITY	Effect of Salmonella endotoxin administered to the pregnant sheep at 133-142 days gestation on fetal oxygenation , maternal and fetal adrenocorticotropic hormone and cortisol , and maternal plasma tumor_necrosis_factor_alpha concentrations .
20932870	0	cortisol	69,77	vasopressin	29,40	cortisol	vasopressin	MESH:D006854	551	Chemical	Gene	reacting|xcomp|START_ENTITY reacting|nmod|END_ENTITY	Autoantibodies reacting with vasopressin and oxytocin in relation to cortisol secretion in mild and moderate depression .
2100284	0	cortisol	63,71	vasopressin	10,21	cortisol	vasopressin	MESH:D006854	551	Chemical	Gene	secretion|amod|START_ENTITY Effect|nmod|secretion Effect|nmod|END_ENTITY	Effect of vasopressin and naloxone alone and in combination on cortisol secretion after dexamethasone pretreatment .
6264791	0	cortisol	42,50	vasopressin	29,40	cortisol	vasopressin	MESH:D006854	551	Chemical	Gene	ACTH|dep|START_ENTITY ACTH|dep|END_ENTITY	Ontogeny of endocrine -LRB- ACTH , vasopressin , cortisol -RRB- responses to hypotension in lamb fetuses .
744021	0	cortisol	92,100	vasopressin	46,57	cortisol	vasopressin	MESH:D006854	551	Chemical	Gene	interactions|nmod|START_ENTITY Changes|dep|interactions Changes|nmod|reactivity reactivity|acl|induced induced|nmod|concentrations concentrations|compound|END_ENTITY	Changes of vascular reactivity induced by low vasopressin concentrations : interactions with cortisol and lithium and possible involvement of prostaglandins .
15414440	0	cortisone	15,24	ACTH	58,62	cortisone	ACTH	MESH:D003348	5443	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	The effects of cortisone and adrenocorticotropic_hormone -LRB- ACTH -RRB- on certain rheumatic_diseases .
6818113	0	cortisone	27,36	VIII	92,96	cortisone	VIII	MESH:D003348	1351	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nsubj|effect	The potentiating effect of cortisone -LRB- prednisolone -RRB- on the fibrinolytic and clotting factor VIII responses to intravenous infusion of adrenaline in man .
3377368	0	cortisone	15,24	acetylcholinesterase	28,48	cortisone	acetylcholinesterase	MESH:D003348	11423(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of cortisone on acetylcholinesterase -LRB- AChE -RRB- in the neonatal and aged thymus .
6998026	0	cortisone	11,20	albumin	42,49	cortisone	albumin	MESH:D003348	24186(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of cortisone on decrease of serum albumin secondary to experimental infections .
108133	0	cortisone	48,57	lactase	85,92	cortisone	lactase	MESH:D003348	226413(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activity activity|compound|END_ENTITY	Opposite effects of one and three injections of cortisone or thyroxine on intestinal lactase activity in suckling mice .
1127379	0	cortisone	84,93	terminal_deoxynucleotidyl_transferase	7,44	cortisone	terminal deoxynucleotidyl transferase	MESH:D003348	21673(Tax:10090)	Chemical	Gene	distribution|nmod|START_ENTITY END_ENTITY|dep|distribution	Murine terminal_deoxynucleotidyl_transferase : cellular distribution and response to cortisone .
383494	0	cortisone	11,20	trehalase	49,58	cortisone	trehalase	MESH:D003348	11181	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|compound|END_ENTITY	Effects of cortisone and thyroxine on intestinal trehalase activity in infant mouse .
11465341	0	cortisone_acetate	100,117	growth_hormone	11,25	cortisone acetate	growth hormone	MESH:C015087	2688	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|Effects Effects|nmod|replacement replacement|amod|END_ENTITY	Effects of growth_hormone replacement on cortisol metabolism in hypopituitary patients treated with cortisone_acetate .
14616886	0	cortisone_acetate	113,130	growth_hormone	15,29	cortisone acetate	growth hormone	MESH:C015087	2688	Chemical	Gene	replacement|amod|START_ENTITY patients|nmod|replacement effects|nmod|patients effects|nmod|deficiency deficiency|amod|END_ENTITY	The effects of growth_hormone deficiency and replacement on glucocorticoid exposure in hypopituitary patients on cortisone_acetate and hydrocortisone replacement .
2107653	0	cortisone_acetate	17,34	growth_hormone	38,52	cortisone acetate	growth hormone	MESH:C015087	2688	Chemical	Gene	START_ENTITY|nmod|response response|amod|END_ENTITY	Acute effects of cortisone_acetate on growth_hormone response to growth_hormone-releasing_hormone in normal adult subjects .
2107653	0	cortisone_acetate	17,34	growth_hormone-releasing_hormone	65,97	cortisone acetate	growth hormone-releasing hormone	MESH:C015087	2691	Chemical	Gene	effects|nmod|START_ENTITY effects|acl|END_ENTITY	Acute effects of cortisone_acetate on growth_hormone response to growth_hormone-releasing_hormone in normal adult subjects .
11166910	0	costunolide	14,25	THP-1	148,153	costunolide	THP-1	MESH:C002602	2736	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition by costunolide of phorbol_ester-induced transcriptional activation of inducible_nitric_oxide_synthase gene in a human monocyte cell line THP-1 .
24163286	0	cotinine	50,58	CYP2A6	13,19	cotinine	CYP2A6	MESH:D003367	1548	Chemical	Gene	START_ENTITY|nsubj|Influence Influence|nmod|END_ENTITY	Influence of CYP2A6 * 4 genotypes on maternal serum cotinine among chinese nonsmoking pregnant women .
11130096	0	cotinine	17,25	interleukin_6	29,42	cotinine	interleukin 6	MESH:D003367	3569	Chemical	Gene	influence|nmod|START_ENTITY influence|nmod|expression expression|amod|END_ENTITY	The influence of cotinine on interleukin_6 expression in smokers with cervical preneoplasia .
2832208	0	coumarin	89,97	AD6	10,13	coumarin	AD6	MESH:C030123	64851	Chemical	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of AD6 -LRB- 8-monochloro-3-beta-diethylamino-ethyl-4-methyl-7-ethoxycarbonylme tho xy coumarin -RRB- on cyclic nucleotide phosphodiesterases in human platelets .
9531487	0	coumarin	120,128	CYP2A5	142,148	coumarin	CYP2A5	MESH:C030123	13087(Tax:10090)	Chemical	Gene	hydroxylase|compound|START_ENTITY hydroxylase|appos|END_ENTITY	Pyrazole-inducible proteins in DBA/2 mouse liver bind with high affinity to the 3 ' - untranslated regions of the mRNAs of coumarin hydroxylase -LRB- CYP2A5 -RRB- and c-jun .
16946554	0	coumarin	61,69	CYP2A6	81,87	coumarin	CYP2A6	MESH:C030123	1548	Chemical	Gene	using|dobj|START_ENTITY using|nmod|END_ENTITY	Characterization of humanized liver from chimeric mice using coumarin as a human CYP2A6 and mouse CYP2A5 probe .
23679955	0	coumarin	71,79	GPR55	54,59	coumarin	GPR55	MESH:C030123	9290	Chemical	Gene	based|nmod|START_ENTITY END_ENTITY|acl|based	Antagonists for the orphan G-protein-coupled receptor GPR55 based on a coumarin scaffold .
24252806	0	coumarin	10,18	P-glycoprotein	53,67	coumarin	P-glycoprotein	MESH:C030123	5243	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Effect of coumarin derivative-mediated inhibition of P-glycoprotein on oral bioavailability and therapeutic efficacy of paclitaxel .
15109623	0	coumarin	49,57	TNF-alpha	73,82	coumarin	TNF-alpha	MESH:C030123	7124	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	Discovery and structure-activity relationship of coumarin derivatives as TNF-alpha inhibitors .
15964220	0	coumarin	11,19	bcl-2	40,45	coumarin	bcl-2	MESH:C030123	596	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|amod|END_ENTITY	Effects of coumarin and 7OH-coumarin on bcl-2 and Bax expression in two human lung_cancer cell lines in vitro .
2025958	0	coumarin	22,30	interleukin-1	89,102	coumarin	interleukin-1	MESH:C030123	3552	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Synergistic effect of coumarin -LRB- 1,2 _ benzopyrone -RRB- and endotoxin in the induction of human interleukin-1 .
19810674	0	coumarin	37,45	monoamine_oxidase_B	46,65	coumarin	monoamine oxidase B	MESH:C030123	4129	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Discovery of a novel class of potent coumarin monoamine_oxidase_B inhibitors : development and biopharmacological profiling of 7 - -LSB- -LRB- 3-chlorobenzyl -RRB- oxy -RSB- -4 - -LSB- -LRB- methylamino -RRB- methyl -RSB- -2 H-chromen-2-one_methanesulfonate -LRB- NW-1772 -RRB- as a highly potent , selective , reversible , and orally active monoamine_oxidase_B inhibitor .
26269086	0	coumarin	63,71	sulfatase	95,104	coumarin	sulfatase	MESH:C030123	347527	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	Synthesis and biological evaluation of thiophosphate tricyclic coumarin derivatives as steroid sulfatase inhibitors .
22980884	0	coumarin	25,33	tyrosinase	58,68	coumarin	tyrosinase	MESH:C030123	7299	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	Biological evaluation of coumarin derivatives as mushroom tyrosinase inhibitors .
16464579	0	coumarins	12,21	5-lipoxygenase	32,46	coumarins	5-lipoxygenase	MESH:D003374	240	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Substituted coumarins as potent 5-lipoxygenase inhibitors .
17635701	0	coumarins	28,37	VKORC1	0,6	coumarins	VKORC1	MESH:D003374	79001	Chemical	Gene	target|nmod|START_ENTITY END_ENTITY|dep|target	VKORC1 : molecular target of coumarins .
26887799	0	coumarins	5,14	paraoxonase_1	44,57	coumarins	paraoxonase 1	MESH:D003374	5444	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Some coumarins and benzoxazinones as potent paraoxonase_1 inhibitors .
16413781	0	coumarins	123,132	thrombin	33,41	coumarins	thrombin	MESH:D003374	2147	Chemical	Gene	the|nmod|START_ENTITY molecule|nmod|the Implications|nmod|molecule Investigation|dep|Implications Investigation|nmod|inhibitors inhibitors|compound|END_ENTITY	Investigation of mechanism-based thrombin inhibitors : Implications of a highly conserved water molecule for the binding of coumarins within the S pocket .
20136105	0	coumaroyltyramine	23,40	albumin	58,65	coumaroyltyramine	albumin	null	213	Chemical	Gene	studies|nmod|START_ENTITY studies|nmod|END_ENTITY	Interaction studies of coumaroyltyramine with human serum albumin and its biological importance .
26341390	0	coumestrol	20,30	Flt3	0,4	coumestrol	Flt3	MESH:D003375	2322	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Flt3 is a target of coumestrol in protecting against UVB-induced skin_photoaging .
8315272	0	coumestrol	97,107	estrogen_receptor	28,45	coumestrol	estrogen receptor	MESH:D003375	2099	Chemical	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	In situ localization of the estrogen_receptor in living cells with the fluorescent phytoestrogen coumestrol .
18457666	0	coumestrol	11,21	farnesoid_X_receptor	59,79	coumestrol	farnesoid X receptor	MESH:D003375	9971	Chemical	Gene	START_ENTITY|nmod|metabolism metabolism|nmod|END_ENTITY	Effects of coumestrol on lipid and glucose metabolism as a farnesoid_X_receptor ligand .
8891181	0	coumestrol	10,20	insulin_receptor	28,44	coumestrol	insulin receptor	MESH:D003375	100008911(Tax:9986)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of coumestrol on the insulin_receptor in erythrocytes and liver membranes of female rabbits .
18096694	0	coumestrol	18,28	pregnane_X_receptor	78,97	coumestrol	pregnane X receptor	MESH:D003375	8856	Chemical	Gene	antagonist|nsubj|START_ENTITY antagonist|nmod|END_ENTITY	The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane_X_receptor .
17081245	0	crassulacean_acid	45,62	CAM	75,78	crassulacean acid	CAM	null	808	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|appos|END_ENTITY	Phosphoenolpyruvate_carboxylase genes in C3 , crassulacean_acid metabolism -LRB- CAM -RRB- and C3/CAM intermediate species of the genus Clusia : rapid reversible C3/CAM switches are based on the C3 housekeeping gene .
23352985	0	creatine	91,99	5-HT1A_receptor	32,47	creatine	5-HT1A receptor	MESH:D003401	15550(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nmod|effect	Evidence for the involvement of 5-HT1A_receptor in the acute antidepressant-like effect of creatine in mice .
9486137	0	creatine	73,81	AMP_deaminase	44,57	creatine	AMP deaminase	MESH:D003401	25028(Tax:10116)	Chemical	Gene	depletion|compound|START_ENTITY END_ENTITY|nmod|depletion	Molecular and kinetic alterations of muscle AMP_deaminase during chronic creatine depletion .
12796718	0	creatine	27,35	CA1	61,64	creatine	CA1	MESH:D003401	759	Chemical	Gene	ratio|compound|START_ENTITY ratio|nmod|END_ENTITY	N-acetylaspartate to total creatine ratio in the hippocampal CA1 sector after transient cerebral_ischemia in gerbils : influence of neuronal elements , reactive gliosis , and tissue atrophy .
8297374	0	creatine	54,62	CHOT1	37,42	creatine	CHOT1	MESH:D003401	50690(Tax:10116)	Chemical	Gene	transports|dobj|START_ENTITY transports|nsubj|END_ENTITY	The putative rat choline transporter CHOT1 transports creatine and is highly expressed in neural and muscle-rich tissues .
19333390	0	creatine	35,43	CK-B	52,56	creatine	CK-B	MESH:D003401	1152	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	Local ATP generation by brain-type creatine kinase -LRB- CK-B -RRB- facilitates cell motility .
7932912	0	creatine	15,23	CK-MM	32,37	creatine	CK-MM	MESH:D003401	1158	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	Elevated serum creatine kinase -LRB- CK-MM -RRB- in petrol sniffers using leaded or unleaded fuel .
1290282	0	creatine	16,24	CKBB	33,37	creatine	CKBB	MESH:D003401	1152	Chemical	Gene	START_ENTITY|dobj|kinase kinase|appos|END_ENTITY	-LSB- Brain-specific creatine kinase -LRB- CKBB -RRB- in umbilical cord blood .
7980414	0	creatine	106,114	CKBB	123,127	creatine	CKBB	MESH:D003401	12709(Tax:10090)	Chemical	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	Kinetics of creatine uptake in the perfused mouse liver : a 31P-n.m.r. study of transgenic_mice expressing creatine kinase -LRB- CKBB -RRB- in the liver .
22567844	0	creatine	36,44	CKMM	53,57	creatine	CKMM	MESH:D003401	1158	Chemical	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	-LSB- Association of the muscle-specific creatine kinase -LRB- CKMM -RRB- gene polymorphism with physical performance of athletes -RSB- .
2703233	0	creatine	65,73	CKMM	82,86	creatine	CKMM	MESH:D003401	1158	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	Myotonic_dystrophy is closely linked to the gene for muscle-type creatine kinase -LRB- CKMM -RRB- .
11147785	0	creatine	15,23	GLUT4	56,61	creatine	GLUT4	MESH:D003401	6517	Chemical	Gene	supplementation|compound|START_ENTITY Effect|nmod|supplementation END_ENTITY|nsubj|Effect	Effect of oral creatine supplementation on human muscle GLUT4 protein content after immobilization .
12932744	0	creatine	48,56	Growth_hormone	0,14	creatine	Growth hormone	MESH:D003401	81668(Tax:10116)	Chemical	Gene	transporter|amod|START_ENTITY expression|nmod|transporter induces|dobj|expression induces|nsubj|END_ENTITY	Growth_hormone induces myocardial expression of creatine transporter and decreases plasma levels of IL-1beta in rats during early postinfarct_cardiac_remodeling .
460177	0	creatine	26,34	Growth_hormone	0,14	creatine	Growth hormone	MESH:D003401	81668(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|amod|END_ENTITY	Growth_hormone effects on creatine uptake by muscle in the hypophysectomized rat .
15234333	0	creatine	62,70	Guanidinoacetate_methyltransferase	0,34	creatine	Guanidinoacetate methyltransferase	MESH:D003401	2593	Chemical	Gene	uptake|amod|START_ENTITY differences|nmod|uptake deficiency|dep|differences deficiency|amod|END_ENTITY	Guanidinoacetate_methyltransferase deficiency : differences of creatine uptake in human brain and muscle .
20576602	5	creatine	1012,1020	NCX1	995,999	creatine	NCX1	MESH:D003401	6546	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Moreover , both sMiCK and the muscle-type creatine kinase -LRB- CKM -RRB- coimmunoprecipitated with NCX1 using lysates of cardiacmyocytes and HEK293T cells that transiently expressed NCX1 and various creatine kinases .
3176814	0	creatine	21,29	Prolactin	0,9	creatine	Prolactin	MESH:D003401	5617	Chemical	Gene	activity|amod|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	Prolactin stimulates creatine kinase activity and DNA synthesis in explants of human amnion .
15690373	0	creatine	36,44	SLC6A8	23,29	creatine	SLC6A8	MESH:D003401	6535	Chemical	Gene	defect|amod|START_ENTITY cause|dobj|defect cause|nsubj|mutations mutations|nmod|END_ENTITY	Two novel mutations in SLC6A8 cause creatine transporter defect and distinctive X-linked mental_retardation in two unrelated Dutch families .
16466692	0	creatine	19,27	SLC6A8	40,46	creatine	SLC6A8	MESH:D003401	6535	Chemical	Gene	transporter|amod|START_ENTITY Stimulation|nmod|transporter END_ENTITY|nsubj|Stimulation	Stimulation of the creatine transporter SLC6A8 by the protein kinase mTOR .
16738945	0	creatine	9,17	SLC6A8	31,37	creatine	SLC6A8	MESH:D003401	6535	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	X-linked creatine transporter -LRB- SLC6A8 -RRB- mutations in about 1 % of males with mental_retardation of unknown etiology .
16763899	0	creatine	28,36	SLC6A8	50,56	creatine	SLC6A8	MESH:D003401	6535	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Overexpression of wild-type creatine transporter -LRB- SLC6A8 -RRB- restores creatine uptake in primary SLC6A8-deficient fibroblasts .
16763899	0	creatine	67,75	SLC6A8	50,56	creatine	SLC6A8	MESH:D003401	6535	Chemical	Gene	uptake|amod|START_ENTITY restores|dobj|uptake restores|nsubj|Overexpression Overexpression|nmod|transporter transporter|appos|END_ENTITY	Overexpression of wild-type creatine transporter -LRB- SLC6A8 -RRB- restores creatine uptake in primary SLC6A8-deficient fibroblasts .
17465020	0	creatine	56,64	SLC6A8	83,89	creatine	SLC6A8	MESH:D003401	6535	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Functional characterization of missense variants in the creatine transporter gene -LRB- SLC6A8 -RRB- : improved diagnostic application .
17603797	0	creatine	70,78	SLC6A8	92,98	creatine	SLC6A8	MESH:D003401	6535	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Mental_retardation and verbal_dyspraxia in a new patient with de novo creatine transporter -LRB- SLC6A8 -RRB- mutation .
19188083	0	creatine	106,114	SLC6A8	45,51	creatine	SLC6A8	MESH:D003401	6535	Chemical	Gene	determination|nmod|START_ENTITY deficiency|nmod|determination Screening|dep|deficiency Screening|dep|END_ENTITY	Screening for X-linked_creatine_transporter _ -LRB- SLC6A8 -RRB- _ deficiency via simultaneous determination of urinary creatine to creatinine ratio by tandem mass-spectrometry .
22644605	0	creatine	102,110	SLC6A8	124,130	creatine	SLC6A8	MESH:D003401	6535	Chemical	Gene	transporter|amod|START_ENTITY responsible|nmod|transporter mutations|amod|responsible mutations|appos|END_ENTITY	Functional and electrophysiological characterization of four non-truncating mutations responsible for creatine transporter -LRB- SLC6A8 -RRB- deficiency_syndrome .
24045174	0	creatine	85,93	SLC6A8	153,159	creatine	SLC6A8	MESH:D003401	6535	Chemical	Gene	detected|nmod|START_ENTITY detected|nmod|mutation mutation|nmod|END_ENTITY	Urine screening for patients with developmental_disabilities detected a patient with creatine transporter_deficiency due to a novel missense mutation in SLC6A8 .
24962355	0	creatine	18,26	SLC6A8	40,46	creatine	SLC6A8	MESH:D003401	6535	Chemical	Gene	transporter|amod|START_ENTITY RNA|nmod|transporter reveals|nsubj|RNA reveals|dep|END_ENTITY	RNA sequencing of creatine transporter -LRB- SLC6A8 -RRB- deficient fibroblasts reveals impairment of the extracellular matrix .
25206338	0	creatine	87,95	SLC6A8	22,28	creatine	SLC6A8	MESH:D003401	102857(Tax:10090)	Chemical	Gene	biosynthesis|compound|START_ENTITY capacity|nmod|biosynthesis display|dobj|capacity display|dep|END_ENTITY	Creatine transporter -LRB- SLC6A8 -RRB- knockout mice display an increased capacity for in vitro creatine biosynthesis in skeletal muscle .
25861866	0	creatine	31,39	SLC6A8	168,174	creatine	SLC6A8	MESH:D003401	6535	Chemical	Gene	deficiency|amod|START_ENTITY frequency|nmod|deficiency frequency|nmod|females females|nmod|population population|acl|using using|dobj|characterization characterization|nmod|variants variants|nmod|gene gene|compound|END_ENTITY	Estimated carrier frequency of creatine transporter deficiency in females in the general population using functional characterization of novel missense variants in the SLC6A8 gene .
6151168	0	creatine	132,140	aspartate_aminotransferase	78,104	creatine	aspartate aminotransferase	MESH:D003401	281012(Tax:9913)	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Milk_fever in the cow -- course of disease in relation to the serum activity of aspartate_aminotransferase , alanine_aminotransferase , creatine kinase and gamma-glutamyltransferase .
1697173	0	creatine	122,130	carcinoembryonal_antigen	26,50	creatine	carcinoembryonal antigen	MESH:D003401	1084	Chemical	Gene	START_ENTITY|nsubj|correlation correlation|nmod|END_ENTITY	-LSB- Statistic correlation of carcinoembryonal_antigen -LRB- CEA -RRB- , alpha-feto_protein -LRB- AFP -RRB- and isoenzymes of mitochondrial and BB creatine phosphokinase -LRB- CK + - BB and CK-MT -RRB- in patients with neoplasms -RSB- .
20816117	0	creatine	62,70	cardiac_troponin_I	30,48	creatine	cardiac troponin I	MESH:D003401	7137	Chemical	Gene	START_ENTITY|nsubj|value value|nmod|END_ENTITY	Long-term prognostic value of cardiac_troponin_I and T versus creatine kinase-MB mass after cardiac surgery in low-risk patients with stable symptoms .
4020882	0	creatine	92,100	catalase	119,127	creatine	catalase	MESH:D003401	847	Chemical	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	Involvement of hydrogen_peroxide and hydroxyl radical in the ` oxygen paradox ' : reduction of creatine kinase release by catalase , allopurinol or deferoxamine , but not by superoxide dismutase .
18552983	0	creatine	111,119	esterase_D	85,95	creatine	esterase D	MESH:D003401	13885(Tax:10090)	Chemical	Gene	kinase|amod|START_ENTITY kinase|amod|END_ENTITY	Proteomic surveillance of retinal autoantigens in endogenous uveitis : implication of esterase_D and brain-type creatine kinase as novel autoantigens .
11297004	0	creatine	6,14	growth_hormone	38,52	creatine	growth hormone	MESH:D003401	2688	Chemical	Gene	loading|compound|START_ENTITY enhances|nsubj|loading enhances|dobj|secretion secretion|compound|END_ENTITY	Acute creatine loading enhances human growth_hormone secretion .
8582399	0	creatine	19,27	growth_hormone	49,63	creatine	growth hormone	MESH:D003401	2688	Chemical	Gene	Elevation|nmod|START_ENTITY phosphokinase|nsubj|Elevation phosphokinase|nmod|treatment treatment|amod|END_ENTITY	Elevation of serum creatine phosphokinase during growth_hormone treatment in patients with multiple pituitary_hormone_deficiency .
14587004	0	creatine	136,144	guanidinoacetate_methyltransferase	39,73	creatine	guanidinoacetate methyltransferase	MESH:D003401	14431(Tax:10090)	Chemical	Gene	deficiency|amod|START_ENTITY study|dobj|deficiency validation|acl|study mice|dep|validation spectroscopy|dep|mice spectroscopy|nmod|END_ENTITY	MR spectroscopy of muscle and brain in guanidinoacetate_methyltransferase -LRB- GAMT -RRB- - deficient mice : validation of an animal model to study creatine deficiency .
24256608	0	creatine	42,50	guanidinoacetate_methyltransferase	76,110	creatine	guanidinoacetate methyltransferase	MESH:D003401	25257(Tax:10116)	Chemical	Gene	biosynthesis|compound|START_ENTITY biosynthesis|nmod|activity activity|compound|END_ENTITY	Alcohol consumption decreases rat hepatic creatine biosynthesis via altered guanidinoacetate_methyltransferase activity .
9322805	0	creatine	92,100	guanidinoacetate_methyltransferase	23,57	creatine	guanidinoacetate methyltransferase	MESH:D003401	2593	Chemical	Gene	synthesis|amod|START_ENTITY error|nmod|synthesis deficiency|appos|error deficiency|amod|END_ENTITY	Guanidino compounds in guanidinoacetate_methyltransferase deficiency , a new inborn error of creatine synthesis .
9843739	0	creatine	33,41	insulin	22,29	creatine	insulin	MESH:D003401	3630	Chemical	Gene	accumulation|amod|START_ENTITY effect|nmod|accumulation effect|nmod|END_ENTITY	Stimulatory effect of insulin on creatine accumulation in human skeletal muscle .
1414933	0	creatine	29,37	myoglobin	12,21	creatine	myoglobin	MESH:D003401	4151	Chemical	Gene	isoforms|amod|START_ENTITY isoforms|compound|END_ENTITY	Patterns of myoglobin and MM creatine kinase isoforms release early after intravenous thrombolysis or direct percutaneous transluminal coronary angioplasty for acute_myocardial_infarction , and implications for the early noninvasive diagnosis of reperfusion .
1625920	0	creatine	24,32	myoglobin	13,22	creatine	myoglobin	MESH:D003401	608715(Tax:9615)	Chemical	Gene	kinase|amod|START_ENTITY kinase|amod|END_ENTITY	-LSB- Kinetics of myoglobin , creatine kinase and aspartate_aminotransferase in uncomplicated and complicated forms of healing of experimental myocardial_infarction -RSB- .
3117569	0	creatine	53,61	myoglobin	113,122	creatine	myoglobin	MESH:D003401	4151	Chemical	Gene	release|amod|START_ENTITY release|compound|END_ENTITY	Comparison of serum cardiac specific troponin-I with creatine kinase , creatine kinase-MB isoenzyme , tropomyosin , myoglobin and C-reactive_protein release in marathon runners : cardiac_or_skeletal_muscle_trauma ?
3117569	0	creatine	70,78	myoglobin	113,122	creatine	myoglobin	MESH:D003401	4151	Chemical	Gene	release|amod|START_ENTITY release|compound|END_ENTITY	Comparison of serum cardiac specific troponin-I with creatine kinase , creatine kinase-MB isoenzyme , tropomyosin , myoglobin and C-reactive_protein release in marathon runners : cardiac_or_skeletal_muscle_trauma ?
11581551	0	creatine	16,24	myosin_heavy_chain	52,70	creatine	myosin heavy chain	MESH:D003401	3133	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of oral creatine and resistance training on myosin_heavy_chain expression .
6721838	0	creatine	10,18	myosin_heavy_chain	34,52	creatine	myosin heavy chain	MESH:D003401	395534(Tax:9031)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|contents contents|nmod|mRNA mRNA|compound|END_ENTITY	Effect of creatine on contents of myosin_heavy_chain and myosin-heavy-chain mRNA in steady-state chicken muscle-cell cultures .
20026378	0	creatine	16,24	myostatin	58,67	creatine	myostatin	MESH:D003401	2660	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of oral creatine and resistance training on serum myostatin and GASP-1 .
23715727	0	creatine	63,71	thioredoxin-interacting_protein	11,42	creatine	thioredoxin-interacting protein	MESH:D003401	56338(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY role|nmod|homeostasis role|nmod|END_ENTITY	A role for thioredoxin-interacting_protein -LRB- Txnip -RRB- in cellular creatine homeostasis .
22982673	0	creatine	43,51	uMtCK	60,65	creatine	uMtCK	MESH:D003401	1159	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	Overexpression of ubiquitous mitochondrial creatine kinase -LRB- uMtCK -RRB- accelerates tumor growth by inhibiting apoptosis of breast_cancer cells and is associated with a poor prognosis in breast_cancer patients .
6454327	3	creatinine	711,721	ATPase	677,683	creatinine	ATPase	MESH:D003404	1769	Chemical	Gene	concentration|compound|START_ENTITY END_ENTITY|nmod|concentration	The children with rapidly progressive uremia had higher activities of Na + , K + - ATPase at the corresponding serum creatinine concentration than those with slowly progressive uremia .
10724055	0	creatinine	71,81	Angiotensin-converting_enzyme	0,29	creatinine	Angiotensin-converting enzyme	MESH:D003404	1636	Chemical	Gene	elevations|nmod|START_ENTITY elevations|amod|END_ENTITY	Angiotensin-converting_enzyme inhibitor-associated elevations in serum creatinine : is this a cause for concern ?
19010142	0	creatinine	49,59	CD30	34,38	creatinine	CD30	MESH:D003404	943	Chemical	Gene	START_ENTITY|nsubj|Association Association|nmod|END_ENTITY	Association between serum soluble CD30 and serum creatinine before and after renal transplantation .
11248475	0	creatinine	130,140	Cystatin_C	0,10	creatinine	Cystatin C	MESH:D003404	1471	Chemical	Gene	comparison|nmod|START_ENTITY END_ENTITY|dep|comparison	Cystatin_C , beta_2-microglobulin , and retinol-binding_protein as indicators of glomerular filtration rate : comparison with plasma creatinine .
16817048	0	creatinine	18,28	Cystatin_C	0,10	creatinine	Cystatin C	MESH:D003404	1471	Chemical	Gene	START_ENTITY|nsubj|versus versus|compound|END_ENTITY	Cystatin_C versus creatinine as a marker of glomerular filtration rate in the newborn .
24004120	0	creatinine	18,28	Cystatin_C	0,10	creatinine	Cystatin C	MESH:D003404	1471	Chemical	Gene	START_ENTITY|nsubj|versus versus|compound|END_ENTITY	Cystatin_C versus creatinine in determining risk based on kidney function .
24350959	0	creatinine	18,28	Cystatin_C	0,10	creatinine	Cystatin C	MESH:D003404	1471	Chemical	Gene	START_ENTITY|nsubj|versus versus|compound|END_ENTITY	Cystatin_C versus creatinine for kidney function-based risk .
3471866	0	creatinine	50,60	N-acetyl-beta-D-glucosaminidase	8,39	creatinine	N-acetyl-beta-D-glucosaminidase	MESH:D003404	10724	Chemical	Gene	concentrations|compound|START_ENTITY concentrations|compound|END_ENTITY	Urinary N-acetyl-beta-D-glucosaminidase and serum creatinine concentrations predict impaired excretion of methotrexate .
6532266	0	creatinine	97,107	N-acetyl-beta-D-glucosaminidase	133,164	creatinine	N-acetyl-beta-D-glucosaminidase	MESH:D003404	10724	Chemical	Gene	START_ENTITY|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Effects of intravenous urography using sodium and meglumine_ioxitalamate -LRB- Telebrix 38 -RRB- on blood creatinine and urinary excretion of N-acetyl-beta-D-glucosaminidase -RSB- .
24646860	0	creatinine	92,102	OAT2	46,50	creatinine	OAT2	MESH:D003404	10864	Chemical	Gene	secretion|nmod|START_ENTITY END_ENTITY|nmod|secretion	Contribution of the organic anion transporter OAT2 to the renal active tubular secretion of creatinine and mechanism for serum creatinine elevations caused by cobicistat .
22338083	0	creatinine	55,65	OAT3	41,45	creatinine	OAT3	MESH:D003404	19879(Tax:10090)	Chemical	Gene	secretion|compound|START_ENTITY END_ENTITY|nmod|secretion	A role for the organic anion transporter OAT3 in renal creatinine secretion in mice .
6252672	0	creatinine	29,39	PTH	18,21	creatinine	PTH	MESH:D003404	5741	Chemical	Gene	START_ENTITY|nsubj|Interrelations Interrelations|nmod|END_ENTITY	Interrelations of PTH , cAMP , creatinine and uric_acid in nephrectomized patients under DNA or PTH application .
16194413	0	creatinine	99,109	angiotensin-converting_enzyme	5,34	creatinine	angiotensin-converting enzyme	MESH:D003404	1636	Chemical	Gene	level|amod|START_ENTITY micromol/L|nsubj|level serum|xcomp|micromol/L END_ENTITY|dep|serum	-LSB- Can angiotensin-converting_enzyme inhibitor be used in chronic_kidney_disease patients with serum creatinine level greater than 266 micromol/L ? -RSB- .
8452322	0	creatinine	83,93	angiotensin-converting_enzyme	32,61	creatinine	angiotensin-converting enzyme	MESH:D003404	1636	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Long-term stabilizing effect of angiotensin-converting_enzyme inhibition on plasma creatinine and on proteinuria in normotensive type II diabetic patients .
3906418	1	creatinine	55,65	beta-2-microglobulin	98,118	creatinine	beta-2-microglobulin	MESH:D003404	567	Chemical	Gene	START_ENTITY|nmod|concentration concentration|nmod|END_ENTITY	Value of serum creatinine versus urinary concentration of beta-2-microglobulin .
6183598	0	creatinine	96,106	beta_2_microglobulin	23,43	creatinine	beta 2 microglobulin	MESH:D003404	567	Chemical	Gene	-RSB-|compound|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- Is the serum level of beta_2_microglobulin a better marker of glomerular filtration than blood creatinine ? -RSB- .
7273606	0	creatinine	46,56	creatinine_clearance	14,34	creatinine	creatinine clearance	MESH:D003404	261727	Chemical	Gene	concentration|compound|START_ENTITY END_ENTITY|nmod|concentration	Prediction of creatinine_clearance from serum creatinine concentration based on lean body mass .
11450891	0	creatinine	41,51	cystatin_C	20,30	creatinine	cystatin C	MESH:D003404	1471	Chemical	Gene	START_ENTITY|nsubj|Correlation Correlation|nmod|END_ENTITY	Correlation between cystatin_C and serum creatinine as markers of renal function in patients with neoplasms of the locomotor system .
18298952	0	creatinine	42,52	cystatin_C	21,31	creatinine	cystatin C	MESH:D003404	1471	Chemical	Gene	START_ENTITY|nsubj|study study|nmod|END_ENTITY	Comparative study of cystatin_C and serum creatinine in the estimative of glomerular filtration rate in children .
20073673	0	creatinine	82,92	cystatin_C	61,71	creatinine	cystatin C	MESH:D003404	1471	Chemical	Gene	START_ENTITY|nsubj|variation variation|nmod|END_ENTITY	Comparison of within - and between-subject variation of serum cystatin_C and serum creatinine in children aged 2-13 years .
26299173	0	creatinine	83,93	cystatin_C	6,16	creatinine	cystatin C	MESH:D003404	1471	Chemical	Gene	Correlation|nmod|START_ENTITY levels|dep|Correlation levels|amod|END_ENTITY	Serum cystatin_C levels in preterm newborns in our setting : Correlation with serum creatinine and preterm pathologies .
23729627	0	creatinine	40,50	eGFR	60,64	creatinine	eGFR	MESH:D003404	1956	Chemical	Gene	assay|amod|START_ENTITY assay|nmod|END_ENTITY	The influence of non-specificity of the creatinine assay on eGFR .
17072098	0	creatinine	78,88	hOCT2	135,140	creatinine	hOCT2	MESH:D003404	6582	Chemical	Gene	transport|amod|START_ENTITY transport|nmod|END_ENTITY	Interactions of fluoroquinolone antibacterials , DX-619 and levofloxacin , with creatinine transport by renal organic cation transporter hOCT2 .
19875355	0	creatinine	156,166	neutrophil_gelatinase-associated_lipocalin	6,48	creatinine	neutrophil gelatinase-associated lipocalin	MESH:D003404	3934	Chemical	Gene	patients|nmod|START_ENTITY unstable_angina|nmod|patients NGAL|nmod|unstable_angina NGAL|dep|END_ENTITY	NGAL -LRB- neutrophil_gelatinase-associated_lipocalin -RRB- and L-FABP after percutaneous coronary interventions due to unstable_angina in patients with normal serum creatinine .
21812414	0	crizotinib	31,41	ALK	186,189	crizotinib	ALK	MESH:C551994	238	Chemical	Gene	design|nmod|START_ENTITY factor|nmod|design factor|dobj|c-MET c-MET|appos|END_ENTITY	Structure based drug design of crizotinib -LRB- PF-02341066 -RRB- , a potent and selective dual inhibitor of mesenchymal-epithelial transition factor -LRB- c-MET -RRB- kinase and anaplastic_lymphoma_kinase -LRB- ALK -RRB- .
21933749	0	crizotinib	10,20	ALK	105,108	crizotinib	ALK	MESH:C551994	238	Chemical	Gene	rearrangement|amod|START_ENTITY rearrangement|compound|END_ENTITY	Effect of crizotinib on overall survival in patients with advanced non-small-cell_lung_cancer harbouring ALK gene rearrangement : a retrospective analysis .
22235099	0	crizotinib	28,38	ALK	56,59	crizotinib	ALK	MESH:C551994	238	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|gene gene|compound|END_ENTITY	Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small_cell_lung_cancer .
22282074	0	crizotinib	155,165	ALK	115,118	crizotinib	ALK	MESH:C551994	238	Chemical	Gene	showing|advcl|START_ENTITY showing|dobj|kinase kinase|dep|rearrangement rearrangement|appos|number number|compound|END_ENTITY	Correlations between the percentage of tumor cells showing an anaplastic_lymphoma kinase -LRB- ALK -RRB- gene rearrangement , ALK signal copy number , and response to crizotinib therapy in ALK fluorescence in situ hybridization-positive nonsmall_cell_lung_cancer .
22282074	0	crizotinib	155,165	ALK	90,93	crizotinib	ALK	MESH:C551994	238	Chemical	Gene	showing|advcl|START_ENTITY showing|dobj|kinase kinase|appos|END_ENTITY	Correlations between the percentage of tumor cells showing an anaplastic_lymphoma kinase -LRB- ALK -RRB- gene rearrangement , ALK signal copy number , and response to crizotinib therapy in ALK fluorescence in situ hybridization-positive nonsmall_cell_lung_cancer .
22659414	0	crizotinib	42,52	ALK	96,99	crizotinib	ALK	MESH:C551994	238	Chemical	Gene	mechanism|amod|START_ENTITY investigation|nmod|mechanism investigation|nmod|END_ENTITY	A molecular dynamics investigation on the crizotinib resistance mechanism of C1156Y mutation in ALK .
23328551	0	crizotinib	26,36	ALK	78,81	crizotinib	ALK	MESH:C551994	238	Chemical	Gene	treatment|nmod|START_ENTITY ventilated|nsubj|treatment ventilated|nmod|non-small-cell_lung_cancer non-small-cell_lung_cancer|compound|END_ENTITY	Successful treatment with crizotinib in mechanically ventilated patients with ALK positive non-small-cell_lung_cancer .
23434628	0	crizotinib	121,131	ALK	40,43	crizotinib	ALK	MESH:C551994	238	Chemical	Gene	treatment|amod|START_ENTITY patients|nmod|treatment identifies|nmod|patients identifies|nsubj|analysis analysis|nmod|domain domain|compound|END_ENTITY	Multiplexed deep sequencing analysis of ALK kinase domain identifies resistance mutations in relapsed patients following crizotinib treatment .
23443800	0	crizotinib	26,36	ALK	0,3	crizotinib	ALK	MESH:C551994	238	Chemical	Gene	PF02341066|appos|START_ENTITY PF02341066|compound|END_ENTITY	ALK inhibitor PF02341066 -LRB- crizotinib -RRB- increases sensitivity to radiation in non-small_cell_lung_cancer expressing EML4-ALK .
23584297	0	crizotinib	29,39	ALK	147,150	crizotinib	ALK	MESH:C551994	238	Chemical	Gene	administration|amod|START_ENTITY impact|nmod|administration impact|nmod|rearrangement rearrangement|compound|END_ENTITY	Clinical impact of continued crizotinib administration after isolated central nervous system progression in patients with lung_cancer positive for ALK rearrangement .
23617826	0	crizotinib	47,57	ALK	84,87	crizotinib	ALK	MESH:C551994	238	Chemical	Gene	START_ENTITY|nmod|patient patient|nmod|END_ENTITY	Early pneumothorax as a feature of response to crizotinib therapy in a patient with ALK rearranged lung_adenocarcinoma .
23671386	5	crizotinib	864,874	ALK	885,888	crizotinib	ALK	MESH:C551994	238	Chemical	Gene	development|nmod|START_ENTITY coincided|nmod|development coincided|nmod|END_ENTITY	The discovery of ALK rearrangements in NSCLC serendipitously coincided with the development of crizotinib for other ALK or MET driven malignancies .
23952683	0	crizotinib	13,23	ALK	75,78	crizotinib	ALK	MESH:C551994	238	Chemical	Gene	mechanisms|amod|START_ENTITY Insight|nmod|mechanisms caused|nsubj|Insight caused|nmod|mutations mutations|nmod|kinase kinase|compound|END_ENTITY	Insight into crizotinib resistance mechanisms caused by three mutations in ALK tyrosine kinase using free energy calculation approaches .
24192513	0	crizotinib	26,36	ALK	163,166	crizotinib	ALK	MESH:C551994	238	Chemical	Gene	response|nmod|START_ENTITY _|nsubj|response _|nmod|amplification amplification|nmod|absence absence|nmod|rearrangement rearrangement|compound|END_ENTITY	Major partial response to crizotinib , a dual MET/ALK inhibitor , in a squamous_cell_lung _ -LRB- SCC -RRB- _ carcinoma patient with de novo c-MET amplification in the absence of ALK rearrangement .
24199682	0	crizotinib	105,115	ALK	119,122	crizotinib	ALK	MESH:C551994	238	Chemical	Gene	START_ENTITY|nmod|lung_cancer lung_cancer|compound|END_ENTITY	Dual ALK and EGFR inhibition targets a mechanism of acquired resistance to the tyrosine kinase inhibitor crizotinib in ALK rearranged lung_cancer .
24199682	0	crizotinib	105,115	ALK	5,8	crizotinib	ALK	MESH:C551994	238	Chemical	Gene	resistance|nmod|START_ENTITY mechanism|nmod|resistance targets|dobj|mechanism targets|nsubj|END_ENTITY	Dual ALK and EGFR inhibition targets a mechanism of acquired resistance to the tyrosine kinase inhibitor crizotinib in ALK rearranged lung_cancer .
24279718	0	crizotinib	244,254	ALK	146,149	crizotinib	ALK	MESH:C551994	266802(Tax:10116)	Chemical	Gene	resistance|nmod|START_ENTITY patient|nmod|resistance END_ENTITY|dep|patient	Concomitant occurrence of EGFR -LRB- epidermal_growth_factor_receptor -RRB- and KRAS -LRB- V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog -RRB- mutations in an ALK -LRB- anaplastic_lymphoma_kinase -RRB- - positive lung adenocarcinoma patient with acquired resistance to crizotinib : a case report .
24362875	0	crizotinib	66,76	ALK	12,15	crizotinib	ALK	MESH:C551994	238	Chemical	Gene	predict|nmod|START_ENTITY predict|csubj|Fishing Fishing|nmod|END_ENTITY	Fishing for ALK with immunohistochemistry may predict response to crizotinib .
24478318	0	crizotinib	51,61	ALK	31,34	crizotinib	ALK	MESH:C551994	238	Chemical	Gene	benefit|nmod|START_ENTITY benefit|nmod|inhibition inhibition|compound|END_ENTITY	Clinical benefit of continuing ALK inhibition with crizotinib beyond initial disease progression in patients with advanced ALK-positive NSCLC .
24496003	0	crizotinib	54,64	ALK	18,21	crizotinib	ALK	MESH:C551994	238	Chemical	Gene	responds|xcomp|START_ENTITY variant|acl:relcl|responds variant|compound|END_ENTITY	HIP1-ALK , a novel ALK fusion variant that responds to crizotinib .
24736079	0	crizotinib	218,228	ALK	82,85	crizotinib	ALK	MESH:C551994	238	Chemical	Gene	progressed|nmod|START_ENTITY patients|acl:relcl|progressed alectinib|nmod|patients confers|nmod|alectinib confers|nsubj|mutation mutation|compound|END_ENTITY	Next-generation sequencing reveals a Novel NSCLC ALK F1174V mutation and confirms ALK G1202R mutation confers high-level resistance to alectinib -LRB- CH5424802/RO5424802 -RRB- in ALK-rearranged NSCLC patients who progressed on crizotinib .
24887559	0	crizotinib	78,88	ALK	10,13	crizotinib	ALK	MESH:C551994	238	Chemical	Gene	resistance|amod|START_ENTITY models|nmod|resistance inhibitor|nmod|models inhibitor|nsubj|END_ENTITY	Selective ALK inhibitor alectinib with potent antitumor activity in models of crizotinib resistance .
25028698	0	crizotinib	126,136	ALK	111,114	crizotinib	ALK	MESH:C551994	238	Chemical	Gene	treated|xcomp|START_ENTITY treated|nmod|inhibitor inhibitor|compound|END_ENTITY	A case report of epithelioid inflammatory myofibroblastic_sarcoma with RANBP2-ALK fusion gene treated with the ALK inhibitor , crizotinib .
25115320	0	crizotinib	119,129	ALK	78,81	crizotinib	ALK	MESH:C551994	238	Chemical	Gene	resistance|compound|START_ENTITY patient|nmod|resistance inhibitor|nmod|patient inhibitor|compound|END_ENTITY	Response to chemotherapy , reexposure to crizotinib and treatment with a novel ALK inhibitor in a patient with acquired crizotinib resistance .
25115320	0	crizotinib	40,50	ALK	78,81	crizotinib	ALK	MESH:C551994	238	Chemical	Gene	reexposure|nmod|START_ENTITY reexposure|nmod|inhibitor inhibitor|compound|END_ENTITY	Response to chemotherapy , reexposure to crizotinib and treatment with a novel ALK inhibitor in a patient with acquired crizotinib resistance .
25178493	0	crizotinib	12,22	ALK	87,90	crizotinib	ALK	MESH:C551994	238	Chemical	Gene	Activity|nmod|START_ENTITY Activity|dep|rearranged rearranged|compound|END_ENTITY	Activity of crizotinib over choroidal metastases in non-small-cell_lung_cancer -LRB- NSCLC -RRB- - ALK rearranged : a case report .
25433426	0	crizotinib	36,46	ALK	113,116	crizotinib	ALK	MESH:C551994	238	Chemical	Gene	therapy|amod|START_ENTITY Infected_complex_renal_cysts|nmod|therapy Infected_complex_renal_cysts|nmod|patient patient|nmod|rearrangement rearrangement|amod|positive positive|nmod|END_ENTITY	Infected_complex_renal_cysts during crizotinib therapy in a patient with non-small_cell_lung_cancer positive for ALK rearrangement .
25744866	0	crizotinib	12,22	ALK	76,79	crizotinib	ALK	MESH:C551994	238	Chemical	Gene	START_ENTITY|nmod|rearrangement rearrangement|compound|END_ENTITY	Neoadjuvant crizotinib in advanced inflammatory_myofibroblastic_tumour with ALK gene rearrangement .
26775591	0	crizotinib	59,69	ALK	17,20	crizotinib	ALK	MESH:C551994	238	Chemical	Gene	confers|advcl|START_ENTITY confers|nsubj|mutation mutation|compound|END_ENTITY	A novel acquired ALK F1245C mutation confers resistance to crizotinib in ALK-positive NSCLC but is sensitive to ceritinib .
26786851	0	crizotinib	72,82	ALK	6,9	crizotinib	ALK	MESH:C551994	11682(Tax:10090)	Chemical	Gene	resistance|amod|START_ENTITY overcoming|dobj|resistance inhibits|advcl|overcoming inhibits|nsubj|AZD3463 AZD3463|compound|END_ENTITY	Novel ALK inhibitor AZD3463 inhibits neuroblastoma growth by overcoming crizotinib resistance and inducing apoptosis .
26802023	0	crizotinib	81,91	ALK	0,3	crizotinib	ALK	MESH:C551994	238	Chemical	Gene	resistance|amod|START_ENTITY overcome|dobj|resistance END_ENTITY|acl|overcome	ALK and ROS1 as targeted therapy paradigms and clinical implications to overcome crizotinib resistance .
26973324	1	crizotinib	303,313	ALK	247,250	crizotinib	ALK	MESH:C551994	238	Chemical	Gene	inhibitors|nmod|START_ENTITY END_ENTITY|dobj|inhibitors	BACKGROUND : ALK-rearranged non-small-cell_lung_cancer -LRB- NSCLC -RRB- is sensitive to ALK tyrosine kinase inhibitors -LRB- ALK inhibitors -RRB- such as crizotinib , but resistance invariably develops , often with progression in the brain .
26767038	0	crizotinib	33,43	ROS1	0,4	crizotinib	ROS1	MESH:C551994	6098	Chemical	Gene	mutation|nmod|START_ENTITY mutation|compound|END_ENTITY	ROS1 mutation and treatment with crizotinib in a 30-year old Caucasian woman with stage IV non-small_cell_lung_cancer / adenocarcinoma and complete remission .
24432909	0	crizotinib	113,123	anaplastic_lymphoma_kinase	63,89	crizotinib	anaplastic lymphoma kinase	MESH:C551994	238	Chemical	Gene	mutations|amod|START_ENTITY mutations|compound|END_ENTITY	Design of potent and selective inhibitors to overcome clinical anaplastic_lymphoma_kinase mutations resistant to crizotinib .
21812414	0	crizotinib	31,41	c-MET	140,145	crizotinib	c-MET	MESH:C551994	4233	Chemical	Gene	design|nmod|START_ENTITY factor|nmod|design factor|dobj|END_ENTITY	Structure based drug design of crizotinib -LRB- PF-02341066 -RRB- , a potent and selective dual inhibitor of mesenchymal-epithelial transition factor -LRB- c-MET -RRB- kinase and anaplastic_lymphoma_kinase -LRB- ALK -RRB- .
24192513	0	crizotinib	26,36	c-MET	125,130	crizotinib	c-MET	MESH:C551994	4233	Chemical	Gene	response|nmod|START_ENTITY _|nsubj|response _|nmod|amplification amplification|compound|END_ENTITY	Major partial response to crizotinib , a dual MET/ALK inhibitor , in a squamous_cell_lung _ -LRB- SCC -RRB- _ carcinoma patient with de novo c-MET amplification in the absence of ALK rearrangement .
16580346	0	crocetin	55,63	ERK1/2	0,6	crocetin	ERK1/2	MESH:C010561	5595;5594	Chemical	Gene	effect|nmod|START_ENTITY involved|nmod|effect involved|nsubjpass|END_ENTITY	ERK1/2 pathway is involved in the inhibitory effect of crocetin on angiotensin_II-induced vascular smooth muscle cell proliferation .
17109849	0	crocetin	41,49	ERK1/2	76,82	crocetin	ERK1/2	MESH:C010561	5595;5594	Chemical	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	Involvement of Ca2 + in the inhibition by crocetin of angiotensin_II-induced ERK1/2 activation in vascular smooth muscle cells .
25924472	0	crocetin	12,20	VCAM-1	24,30	crocetin	VCAM-1	MESH:C010561	7412	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	-LSB- Effects of crocetin on VCAM-1 expression in human umbilical vein endothelial cells and monocyte-endothelial cell adhesion -RSB- .
16154540	0	crocetin	63,71	vascular_cell_adhesion_molecule-1	15,48	crocetin	vascular cell adhesion molecule-1	MESH:C010561	100008901(Tax:9986)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Suppression of vascular_cell_adhesion_molecule-1 expression by crocetin contributes to attenuation of atherosclerosis in hypercholesterolemic rabbits .
24401376	0	crocin	26,32	CREB	85,89	crocin	CREB	MESH:C029036	81646(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|levels levels|nmod|END_ENTITY	Antidepressant effects of crocin and its effects on transcript and protein levels of CREB , BDNF , and VGF in rat hippocampus .
27094045	0	crocin	11,17	VEGF-A	70,76	crocin	VEGF-A	MESH:C029036	83785(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of crocin and voluntary_exercise , alone or combined , on heart VEGF-A and HOMA-IR of HFD/STZ induced type 2 diabetic rats .
940605	0	crotapotin	81,91	phospholipase_A	44,59	crotapotin	phospholipase A	MESH:D003439	288025(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Neurotoxic and myotoxic effects of crotalus phospholipase_A and its complex with crotapotin .
22931872	0	cryoprecipitate	75,90	EGF	49,52	cryoprecipitate	EGF	null	100008808(Tax:9986)	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	-LSB- Therapeutic effects of epidermal_growth_factor -LRB- EGF -RRB- combined with plasma cryoprecipitate -LRB- CRYO -RRB- on the corneal_injury induced by paraquat -RSB- .
22931872	0	cryoprecipitate	75,90	epidermal_growth_factor	24,47	cryoprecipitate	epidermal growth factor	null	100008808(Tax:9986)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	-LSB- Therapeutic effects of epidermal_growth_factor -LRB- EGF -RRB- combined with plasma cryoprecipitate -LRB- CRYO -RRB- on the corneal_injury induced by paraquat -RSB- .
18805405	0	cryptotanshinone	53,69	CYP3A4	43,49	cryptotanshinone	CYP3A4	MESH:C037886	1576	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	PXR-mediated transcriptional activation of CYP3A4 by cryptotanshinone and tanshinone_IIA .
23041420	0	cryptotanshinone	77,93	P-gp	127,131	cryptotanshinone	P-gp	MESH:C037886	287115(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Coexisted components of Salvia miltiorrhiza enhance intestinal absorption of cryptotanshinone via inhibition of the intestinal P-gp .
4945195	0	crystal_violet	61,75	lon	96,99	crystal violet	lon	MESH:D005840	20466934	Chemical	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Bacterial cell division regulation : physiological effects of crystal_violet on Escherichia_coli lon + and lon - strains .
8984904	0	cucumisin	26,35	serine_protease	45,60	cucumisin	serine protease	null	2147	Chemical	Gene	activity|nmod|START_ENTITY END_ENTITY|nsubj|activity	Milk-clotting activity of cucumisin , a plant serine_protease from melon fruit .
16707113	0	cucurbitacin_I	121,135	CTGF	112,116	cucurbitacin I	CTGF	MESH:C038106	1490	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|appos|END_ENTITY	STAT3-independent inhibition of lysophosphatidic_acid-mediated upregulation of connective_tissue_growth_factor -LRB- CTGF -RRB- by cucurbitacin_I .
3125991	0	cumene_hydroperoxide	11,31	adenosine_diphosphate_ribosyl_transferase	35,76	cumene hydroperoxide	adenosine diphosphate ribosyl transferase	MESH:C007164	142	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of cumene_hydroperoxide on adenosine_diphosphate_ribosyl_transferase in mononuclear leukocytes of patients with adenomatous_polyps in the colon .
7317537	0	cumene_hydroperoxide	83,103	methemoglobin	114,127	cumene hydroperoxide	methemoglobin	MESH:C007164	3048	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Effects of phospholipids on oxidative demethylation of dimethylcyclohexylamine by cumene_hydroperoxide involving methemoglobin -RSB- .
7574687	0	cumyl_hydroperoxide	49,68	cytochrome_P450_1A2	97,116	cumyl hydroperoxide	cytochrome P450 1A2	MESH:C007164	1544	Chemical	Gene	reaction|amod|START_ENTITY reaction|nmod|END_ENTITY	Marked effects of alcohols and imidazoles on the cumyl_hydroperoxide reaction with the wild-type cytochrome_P450_1A2 .
12962705	0	cupferron	22,31	tyrosinase	90,100	cupferron	tyrosinase	MESH:C031808	7299	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nsubj|effects	Inhibitory effects of cupferron on the monophenolase and diphenolase activity of mushroom tyrosinase .
24422402	0	curcumin	11,19	AKT	37,40	curcumin	AKT	MESH:D003474	11651(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of curcumin on expression of AKT and p-AKT in hippocampus CA1 area of App/PS1 double transgenic_mice -RSB- .
22997831	0	curcumin	11,19	APP/PS1	61,68	curcumin	APP/PS1	MESH:D003474	11820;19164	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of curcumin on synapse-related protein expression of APP/PS1 double transgenic_mice -RSB- .
17640564	0	curcumin	140,148	Akt	87,90	curcumin	Akt	MESH:D003474	207	Chemical	Gene	effect|nmod|START_ENTITY involved|nmod|effect involved|nsubjpass|END_ENTITY	Up-regulation of aldose reductase expression mediated by phosphatidylinositol_3-kinase / Akt and Nrf2 is involved in the protective effect of curcumin against oxidative damage .
18420184	8	curcumin	1153,1161	BDNF	1138,1142	curcumin	BDNF	MESH:D003474	24225(Tax:10116)	Chemical	Gene	levels|nmod|START_ENTITY levels|amod|END_ENTITY	In addition , the up-regulation of BDNF levels by curcumin was also suppressed by K252a .
24469677	0	curcumin	59,67	BF2	42,45	curcumin	BF2	MESH:D003474	2290	Chemical	Gene	complexes|nmod|START_ENTITY complexes|nummod|END_ENTITY	Syntheses and photophysical properties of BF2 complexes of curcumin analogues .
20950605	0	curcumin	56,64	B_lymphocyte_stimulator	18,41	curcumin	B lymphocyte stimulator	MESH:D003474	10673	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Downregulation of B_lymphocyte_stimulator expression by curcumin in B lymphocyte via suppressing nuclear translocation of NF-kB .
17332930	0	curcumin	97,105	Bcl-2	15,20	curcumin	Bcl-2	MESH:D003474	596	Chemical	Gene	p53|nmod|START_ENTITY Involvement|dep|p53 Involvement|nmod|members members|compound|END_ENTITY	Involvement of Bcl-2 family members , phosphatidylinositol 3 ' - kinase/AKT and mitochondrial p53 in curcumin -LRB- diferulolylmethane -RRB- - induced apoptosis in prostate_cancer .
25960232	0	curcumin	62,70	Bcl-2	92,97	curcumin	Bcl-2	MESH:D003474	596	Chemical	Gene	potential|nmod|START_ENTITY potential|acl:relcl|hindered hindered|nmod|END_ENTITY	Inhibition of PI3K signaling triggered apoptotic potential of curcumin which is hindered by Bcl-2 through activation of autophagy in MCF-7 cells .
26464676	0	curcumin	10,18	Bcl-2	22,27	curcumin	Bcl-2	MESH:D003474	12043(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of curcumin on Bcl-2 and Bax expression in nude_mice prostate_cancer .
26387034	0	curcumin	73,81	CISD2	92,97	curcumin	CISD2	MESH:D003474	493856	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	CISD2 serves a novel role as a suppressor of nitric_oxide signalling and curcumin increases CISD2 expression in spinal_cord_injuries .
11566484	0	curcumin	70,78	COX-2	41,46	curcumin	COX-2	MESH:D003474	5743	Chemical	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Specific inhibition of cyclooxygenase-2 -LRB- COX-2 -RRB- expression by dietary curcumin in HT-29 human colon_cancer cells .
16543625	0	curcumin	11,19	COX-2	58,63	curcumin	COX-2	MESH:D003474	17709(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of curcumin on tumor angiogenesis and biomarkers , COX-2 and VEGF , in hepatocellular_carcinoma cell-implanted nude_mice .
17827730	5	curcumin	1303,1311	COX-2	1267,1272	curcumin	hsp70	MESH:D003474	266759(Tax:10116)	Chemical	Gene	attenuated|nsubj|START_ENTITY suppressed|advcl|attenuated suppressed|dobj|expression expression|nmod|BDNF BDNF|dep|END_ENTITY	Moreover , Cp-Mn and DiAc-Cp-Mn administration suppressed the KA-induced expression of c-jun , COX-2 , BDNF , and iNOS mRNA , whereas curcumin attenuated only iNOS mRNA expression .
20399909	0	curcumin	78,86	COX-2	0,5	curcumin	COX-2	MESH:D003474	17709(Tax:10090)	Chemical	Gene	essential|nmod|START_ENTITY essential|nsubj|signaling signaling|compound|END_ENTITY	COX-2 and PGE2 signaling is essential for the regulation of IDO expression by curcumin in murine bone marrow-derived dendritic cells .
23829533	0	curcumin	29,37	CRM1	0,4	curcumin	CRM1	MESH:D003474	7514	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	CRM1 is a cellular target of curcumin : new insights for the myriad of biological effects of an ancient spice .
21506134	0	curcumin	16,24	CYP3A	120,125	curcumin	CYP3A	MESH:D003474	170509(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|dep|role role|nmod|END_ENTITY	Effects of oral curcumin on the pharmacokinetics of intravenous and oral etoposide in rats : possible role of intestinal CYP3A and P-gp inhibition by curcumin .
16387490	0	curcumin	109,117	Cyclooxygenase-2	0,16	curcumin	Cyclooxygenase-2	MESH:D003474	19225(Tax:10090)	Chemical	Gene	modification|nmod|START_ENTITY expression|dep|modification expression|amod|END_ENTITY	Cyclooxygenase-2 expression and oxidative DNA adducts in murine intestinal adenomas : modification by dietary curcumin and implications for clinical trials .
24200537	0	curcumin	21,29	DJ-1	139,143	curcumin	DJ-1	MESH:D003474	117287(Tax:10116)	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|appos|END_ENTITY	Liposomal-formulated curcumin -LSB- Lipocurc -RSB- targeting HDAC -LRB- histone deacetylase -RRB- prevents apoptosis and improves motor deficits in Park_7 -LRB- DJ-1 -RRB- - knockout rat model of Parkinson 's _ disease : implications for epigenetics-based nanotechnology-driven drug platform .
18214481	6	curcumin	1262,1270	EGFR	1332,1336	curcumin	AQP3	MESH:D003474	360	Chemical	Gene	effects|nmod|START_ENTITY mediated|nsubjpass|effects mediated|nmod|effects effects|nmod|activation activation|compound|END_ENTITY	We also find that curcumin , a well known anti-ovarian_cancer drug , down-regulates AQP3 expression and reduces cell migration in CaOV3 , and the effects of curcumin are mediated , at least in part , by its inhibitory effects on EGFR and downstream AKT/ERK activation .
23245570	0	curcumin	86,94	EGFR	105,109	curcumin	EGFR	MESH:D003474	1956	Chemical	Gene	analogous|nmod|START_ENTITY cyclohexanone|xcomp|analogous cyclohexanone|nmod|inhibitors inhibitors|compound|END_ENTITY	Design , synthesis and molecular docking of a,b-unsaturated _ cyclohexanone analogous of curcumin as potent EGFR inhibitors with antiproliferative activity .
23880083	0	curcumin	33,41	EGFR	86,90	curcumin	EGFR	MESH:D003474	1956	Chemical	Gene	analogues|compound|START_ENTITY analogues|dep|design design|nmod|signaling signaling|compound|END_ENTITY	Exploring pyrimidine-substituted curcumin analogues : design , synthesis and effects on EGFR signaling .
19777504	0	curcumin	21,29	ERK	107,110	curcumin	ERK	MESH:D003474	5594	Chemical	Gene	START_ENTITY|nmod|motility motility|nmod|cells cells|nmod|suppression suppression|nmod|END_ENTITY	Inhibitory effect of curcumin on motility of human oral squamous_carcinoma YD-10B cells via suppression of ERK and NF-kappaB activations .
21932059	0	curcumin	56,64	ERK	73,76	curcumin	ERK	MESH:D003474	5594	Chemical	Gene	suppressed|nmod|START_ENTITY suppressed|nmod|END_ENTITY	ICAM-1 and IL-8 are expressed by DEHP and suppressed by curcumin through ERK and p38 MAPK in human umbilical vein endothelial cells .
22913328	0	curcumin	94,102	ERK1/2	44,50	curcumin	ERK1/2	MESH:D003474	50689;116590	Chemical	Gene	signaling|nmod|START_ENTITY signaling|compound|END_ENTITY	Attenuation of endothelin-1-induced PKB and ERK1/2 signaling , as well as Egr-1 expression , by curcumin in A-10 vascular smooth muscle cells .
10674404	0	curcumin	45,53	Egr-1	36,41	curcumin	Egr-1	MESH:D003474	1958	Chemical	Gene	Suppression|nmod|START_ENTITY Suppression|nmod|END_ENTITY	Suppression of transcription factor Egr-1 by curcumin .
26761722	0	curcumin	11,19	Erk	109,112	curcumin	Erk	MESH:D003474	26413(Tax:10090)	Chemical	Gene	ameliorates|nsubj|START_ENTITY ameliorates|advcl|regulating regulating|dobj|activation activation|appos|p38 p38|dep|END_ENTITY	Intranasal curcumin ameliorates airway_inflammation and obstruction by regulating MAPKinase activation -LRB- p38 , Erk and JNK -RRB- and prostaglandin_D2 release in murine model of asthma .
19304795	0	curcumin	57,65	FSH-R	95,100	curcumin	FSH-R	MESH:D003474	14309(Tax:10090)	Chemical	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Modulation of ovarian structure and abdominal_obesity in curcumin - and flutamide-treated aging FSH-R haploinsufficient mice .
26833194	0	curcumin	18,26	GADD45a	0,7	curcumin	GADD45a	MESH:D003474	1647	Chemical	Gene	sensitivity|compound|START_ENTITY modulates|dobj|sensitivity modulates|nsubj|END_ENTITY	GADD45a modulates curcumin sensitivity through c-Abl - _ and_JNK-dependent signaling pathways in a mismatch repair-dependent manner .
26711214	0	curcumin	78,86	GSTP1	17,22	curcumin	GSTP1	MESH:D003474	2950	Chemical	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	-LSB- Relationship of GSTP1 lower expression and multidrug resistance reversing of curcumin on human colon_carcinoma cells -RSB- .
16850746	0	curcumin	31,39	HDAC1	0,5	curcumin	HDAC1	MESH:D003474	3065	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	HDAC1 expression and effect of curcumin on proliferation of Raji cells .
21545828	0	curcumin	27,35	HO-1	120,124	curcumin	HO-1	MESH:D003474	24451(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|relationship relationship|nmod|system system|compound|END_ENTITY	Hepatoprotective effect of curcumin in lipopolysaccharide / - galactosamine model of liver_injury in rats : relationship to HO-1 / CO antioxidant system .
26047311	0	curcumin	29,37	HO-1	11,15	curcumin	HO-1	MESH:D003474	24451(Tax:10116)	Chemical	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	Microglial HO-1 induction by curcumin provides antioxidant , antineuroinflammatory , and glioprotective effects .
11322385	0	curcumin	76,84	HSP70	106,111	curcumin	HSP70	MESH:D003474	3308	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Alternative activation of extracellular signal-regulated protein kinases in curcumin and arsenite-induced HSP70 gene expression in human colorectal_carcinoma cells .
19074641	0	curcumin	10,18	IL-6	54,58	curcumin	IL-6	MESH:D003474	3569	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effect of curcumin on acidic pH-induced expression of IL-6 and IL-8 in human esophageal epithelial cells -LRB- HET-1A -RRB- : role of PKC , MAPKs , and NF-kappaB .
16406419	0	curcumin	10,18	LDL_receptor	40,52	curcumin	LDL receptor	MESH:D003474	16835(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	Effect of curcumin on the expression of LDL_receptor in mouse macrophages .
19895312	0	curcumin	10,18	LRP	55,58	curcumin	LRP	MESH:D003474	9961	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of curcumin on lung_resistance-related_protein -LRB- LRP -RRB- in retinoblastoma cells .
17609337	0	curcumin	22,30	MD-2	0,4	curcumin	MD-2	MESH:D003474	23643	Chemical	Gene	target|nmod|START_ENTITY END_ENTITY|nmod|target	MD-2 as the target of curcumin in the inhibition of response to LPS .
17121181	0	curcumin	21,29	MDR1	33,37	curcumin	MDR1	MESH:D003474	5243	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|compound|END_ENTITY	Inhibitory effect of curcumin on MDR1 gene expression in patient leukemic cells .
26321746	0	curcumin	12,20	MEG3	74,78	curcumin	MEG3	MESH:D003474	55384	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Dendrosomal curcumin increases expression of the long non-coding RNA gene MEG3 via up-regulation of epi-miRs in hepatocellular_cancer .
19594013	0	curcumin	22,30	MMP-2	34,39	curcumin	MMP-2	MESH:D003474	17390(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Inhibitory effect of curcumin on MMP-2 and MMP-9 expression induced by polyethylene wear particles and its mechanism -RSB- .
24134840	0	curcumin	19,27	MST1	0,4	curcumin	MST1	MESH:D003474	4485	Chemical	Gene	activation|nmod|START_ENTITY activation|nummod|END_ENTITY	MST1 activation by curcumin mediates JNK activation , Foxo3a nuclear translocation and apoptosis in melanoma cells .
24293118	0	curcumin	47,55	MiR-21	0,6	curcumin	MiR-21	MESH:D003474	406991	Chemical	Gene	activities|nmod|START_ENTITY suppresses|dobj|activities suppresses|nsubj|END_ENTITY	MiR-21 suppresses the anticancer activities of curcumin by targeting PTEN gene in human non-small_cell_lung_cancer A549 cells .
26097529	0	curcumin	45,53	NF-Kb	157,162	curcumin	NF-Kb	MESH:D003474	81736(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|acl|reperfusion reperfusion|advcl|inhibiting inhibiting|dobj|pathway pathway|nmod|END_ENTITY	Anti-inflammatory and antioxidant effects of curcumin on acute_lung_injury in a rodent model of intestinal_ischemia reperfusion by inhibiting the pathway of NF-Kb .
25215173	0	curcumin	26,34	NF-kB	147,152	curcumin	NF-kB	MESH:D003474	81736(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY induced|nsubj|effects induced|advcl|inhibiting inhibiting|dobj|pathway pathway|nmod|END_ENTITY	The protective effects of curcumin on experimental acute_liver_lesion induced by intestinal_ischemia-reperfusion through inhibiting the pathway of NF-kB in a rat model .
10557090	0	curcumin	87,95	NF-kappaB	119,128	curcumin	NF-kappaB	MESH:D003474	4790	Chemical	Gene	cells|nmod|START_ENTITY expression|nmod|cells Inhibition|nmod|expression involves|nsubj|Inhibition involves|dobj|inhibition inhibition|nmod|activation activation|amod|END_ENTITY	Inhibition of cyclo-oxygenase_2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-kappaB activation via the NIK/IKK signalling complex .
16124875	0	curcumin	19,27	NF-kappaB	51,60	curcumin	NF-kappaB	MESH:D003474	18033(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|amod|END_ENTITY	Effects of dietary curcumin or N-acetylcysteine on NF-kappaB activity and contractile performance in ambulatory and unloaded murine soleus .
18588981	1	curcumin	325,333	NF-kappaB	173,182	curcumin	NF-kappaB	MESH:D003474	4790	Chemical	Gene	investigated|nmod|START_ENTITY differs|parataxis|investigated differs|nmod|sequence sequence|appos|END_ENTITY	The osmotic response element -LRB- ORE -RRB- differs from the nuclear_factor-kappaB -LRB- NF-kappaB -RRB- binding sequence by a single base pair ; therefore , we investigated the involvement of NF-kappaB in the induction of aldose reductase -LRB- AR -RRB- by curcumin .
19520742	0	curcumin	164,172	NF-kappaB	134,143	curcumin	NF-kappaB	MESH:D003474	4790	Chemical	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Vascular_cell_adhesion_molecule-1 expression in human intestinal microvascular endothelial cells is regulated by PI 3-kinase/Akt/MAPK / NF-kappaB : inhibitory role of curcumin .
20968042	0	curcumin	42,50	NF-kappaB	11,20	curcumin	NF-kappaB	MESH:D003474	18033(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|inhibitor inhibitor|amod|END_ENTITY	-LSB- Effect of NF-kappaB activation inhibitor curcumin on the oogenesis and follicular cell death in immune ovarian_failure in mice -RSB- .
22469857	0	curcumin	40,48	NF-kappa_B	18,28	curcumin	NF-kappa B	MESH:D003474	4790	Chemical	Gene	inhibitors|dobj|START_ENTITY inhibitors|nsubj|effect effect|nmod|END_ENTITY	The effect of the NF-kappa_B inhibitors curcumin and lactacystin on myogenic differentiation of rhabdomyosarcoma cells .
24737429	0	curcumin	11,19	NgR	49,52	curcumin	NgR	MESH:D003474	113912(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of curcumin on hippocampal expression of NgR and axonal regeneration in Ab-induced cognitive_disorder rats .
16628653	0	curcumin	27,35	Notch-1	0,7	curcumin	Notch-1	MESH:D003474	4851	Chemical	Gene	down-regulation|nmod|START_ENTITY down-regulation|amod|END_ENTITY	Notch-1 down-regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic_cancer cells .
12167476	0	curcumin	56,64	P-glycoprotein	14,28	curcumin	P-glycoprotein	MESH:D003474	5243	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|expression expression|amod|END_ENTITY	Modulation of P-glycoprotein expression and function by curcumin in multidrug-resistant human KB cells .
14530869	0	curcumin	75,83	P-glycoprotein	0,14	curcumin	P-glycoprotein	MESH:D003474	5243	Chemical	Gene	induced|nmod|START_ENTITY pathway|acl|induced change|dobj|pathway change|nsubj|expression expression|amod|END_ENTITY	P-glycoprotein expression does not change the apoptotic pathway induced by curcumin in HL-60 cells .
16960658	0	curcumin	207,215	P-glycoprotein	55,69	curcumin	P-glycoprotein	MESH:D003474	5243	Chemical	Gene	metabolite|nmod|START_ENTITY Modulation|appos|metabolite Modulation|appos|END_ENTITY	Modulation of function of three ABC drug transporters , P-glycoprotein -LRB- ABCB1 -RRB- , mitoxantrone resistance protein -LRB- ABCG2 -RRB- and multidrug resistance protein 1 -LRB- ABCC1 -RRB- by tetrahydrocurcumin , a major metabolite of curcumin .
24229684	0	curcumin	21,29	P-glycoprotein	134,148	curcumin	P-glycoprotein	MESH:D003474	5243	Chemical	Gene	START_ENTITY|acl|multidrug multidrug|nmod|regulation regulation|nmod|END_ENTITY	Reversion effects of curcumin on multidrug resistance of MNNG/HOS human osteosarcoma cells in vitro and in vivo through regulation of P-glycoprotein .
9651124	0	curcumin	11,19	P-glycoprotein	23,37	curcumin	P-glycoprotein	MESH:D003474	287115(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of curcumin on P-glycoprotein in primary cultures of rat hepatocytes .
18161303	0	curcumin	15,23	P21	75,78	curcumin	P21	MESH:D003474	1026	Chemical	Gene	START_ENTITY|nmod|promotion promotion|nmod|END_ENTITY	-LSB- Inhibition of curcumin on histone_deacetylase and expression promotion of P21 -LRB- WAF1/CIP1 -RRB- in HepG2 cells -RSB- .
16468334	0	curcumin	12,20	P53	55,58	curcumin	P53	MESH:D003474	7157	Chemical	Gene	START_ENTITY|nmod|acetylation acetylation|nmod|histone histone|nummod|END_ENTITY	-LSB- Effects of curcumin on the acetylation of histone H3 , P53 and the proliferation of NB4 cells -RSB- .
23944055	0	curcumin	12,20	PI3K	38,42	curcumin	PI3K	MESH:D003474	18708(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of curcumin on expression of PI3K and p-pI3K in hippocampus of AD mice -RSB- .
21658388	0	curcumin	29,37	PKCa	90,94	curcumin	PKCa	MESH:D003474	5578	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Inhibitory mechanism of pure curcumin on Wilms ' _ tumor_1 -LRB- WT1 -RRB- gene expression through the PKCa signaling pathway in leukemic K562 cells .
17372590	0	curcumin	59,67	PPARgamma	98,107	curcumin	PPARgamma	MESH:D003474	25664(Tax:10116)	Chemical	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	The interruption of the PDGF and EGF signaling pathways by curcumin stimulates gene expression of PPARgamma in rat activated hepatic stellate cell in vitro .
17650800	0	curcumin	11,19	RelA	91,95	curcumin	RelA	MESH:D003474	309165(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of curcumin on activity of matrix_metalloproteinase_2 , 9 and nuclear expression of RelA in rat hepatic stellate cells by activating peroxisome_proliferator-activated_receptor_gamma signal -RSB- .
23541743	0	curcumin	14,22	SMAD3	111,116	curcumin	SMAD3	MESH:D003474	25631(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|parataxis|END_ENTITY	The effect of curcumin on sepsis-induced acute_lung_injury in a rat model through the inhibition of the TGF-b1 / SMAD3 pathway .
23430957	0	curcumin	5,13	SOCS1	42,47	curcumin	SOCS1	MESH:D003474	8651	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Pure curcumin increases the expression of SOCS1 and SOCS3 in myeloproliferative neoplasms through suppressing class I histone deacetylases .
21527728	0	curcumin	66,74	SREBP2	0,6	curcumin	SREBP2	MESH:D003474	6721	Chemical	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	SREBP2 mediates the modulation of intestinal NPC1L1 expression by curcumin .
19647363	0	curcumin	106,114	STAT3	30,35	curcumin	STAT3	MESH:D003474	6774	Chemical	Gene	inhibition|nmod|START_ENTITY phosphorylation|dep|inhibition phosphorylation|compound|END_ENTITY	Lysophosphatidic_acid induces STAT3 phosphorylation and ovarian_cancer cell motility : their inhibition by curcumin .
20576164	0	curcumin	19,27	STAT3	82,87	curcumin	STAT3	MESH:D003474	6774	Chemical	Gene	FLLL32|compound|START_ENTITY induces|nsubj|FLLL32 induces|nmod|cells cells|nmod|inhibition inhibition|compound|END_ENTITY	The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity .
21138870	0	curcumin	8,16	STAT3	97,102	curcumin	STAT3	MESH:D003474	20848(Tax:10090)	Chemical	Gene	growth|compound|START_ENTITY growth|parataxis|signaling signaling|nsubj|END_ENTITY	Dietary curcumin attenuates_glioma growth in a syngeneic mouse model by inhibition of the JAK1 ,2 / STAT3 signaling pathway .
21443800	0	curcumin	10,18	STAT3	43,48	curcumin	STAT3	MESH:D003474	6774	Chemical	Gene	FLLL32|compound|START_ENTITY decreases|nsubj|FLLL32 decreases|dobj|activity activity|compound|END_ENTITY	The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression , and induces apoptosis in osteosarcoma cell lines .
21885917	0	curcumin	11,19	STAT3	117,122	curcumin	STAT3	MESH:D003474	6774	Chemical	Gene	analog|compound|START_ENTITY HO-3867|appos|analog sensitizes|nsubj|HO-3867 sensitizes|advcl|leading leading|nmod|inhibition inhibition|compound|END_ENTITY	HO-3867 , a curcumin analog , sensitizes cisplatin-resistant ovarian_carcinoma , leading to therapeutic synergy through STAT3 inhibition .
22179587	0	curcumin	4,12	STAT3	123,128	curcumin	STAT3	MESH:D003474	6774	Chemical	Gene	hydrazinocurcumin|amod|START_ENTITY exhibits|nsubj|hydrazinocurcumin exhibits|nmod|carcinogenicity carcinogenicity|nmod|cells cells|nmod|inhibition inhibition|compound|END_ENTITY	The curcumin analogue hydrazinocurcumin exhibits potent suppressive activity on carcinogenicity of breast_cancer cells via STAT3 inhibition .
22899991	0	curcumin	22,30	STAT3	47,52	curcumin	STAT3	MESH:D003474	6774	Chemical	Gene	analogs|nsubj|START_ENTITY analogs|dep|inhibit inhibit|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Structurally modified curcumin analogs inhibit STAT3 phosphorylation and promote apoptosis of human renal_cell_carcinoma and melanoma cell lines .
23621850	0	curcumin	57,65	STAT3	82,87	curcumin	STAT3	MESH:D003474	6774	Chemical	Gene	cells|nmod|START_ENTITY RANK|nmod|cells reactivation|nmod|RANK reactivation|dep|involvement involvement|nmod|inhibition inhibition|compound|END_ENTITY	Epigenetic reactivation of RANK in glioblastoma cells by curcumin : involvement of STAT3 inhibition .
23275693	0	curcumin	65,73	Stat3	43,48	curcumin	Stat3	MESH:D003474	6774	Chemical	Gene	derivatives|amod|START_ENTITY dimerization|nmod|derivatives END_ENTITY|acl|dimerization	Molecular docking studies on inhibition of Stat3 dimerization by curcumin natural derivatives and its conjugates with amino_acids .
24668546	0	curcumin	85,93	TGF-b	23,28	curcumin	TGF-b	MESH:D003474	7040	Chemical	Gene	mechanism|nmod|START_ENTITY mechanism|nmod|END_ENTITY	Molecular mechanism of TGF-b signaling pathway in colon_carcinogenesis and status of curcumin as chemopreventive strategy .
23541743	0	curcumin	14,22	TGF-b1	104,110	curcumin	TGF-b1	MESH:D003474	59086(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|inhibition inhibition|nmod|END_ENTITY	The effect of curcumin on sepsis-induced acute_lung_injury in a rat model through the inhibition of the TGF-b1 / SMAD3 pathway .
26732833	0	curcumin	10,18	TNFR2	22,27	curcumin	TNFR2	MESH:D003474	156767(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of curcumin on TNFR2 and TRAF2 in unilateral_ureteral_obstruction in rats .
17640182	0	curcumin	79,87	TRPV1	44,49	curcumin	TRPV1	MESH:D003474	193034(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nmod|effect	A potential role for the vanilloid receptor TRPV1 in the therapeutic effect of curcumin in dinitrobenzene_sulphonic_acid-induced colitis in mice .
25224922	0	curcumin	29,37	Transthyretin	0,13	curcumin	Transthyretin	MESH:D003474	7276	Chemical	Gene	complexes|nmod|START_ENTITY complexes|compound|END_ENTITY	Transthyretin complexes with curcumin and bromo-estradiol : evaluation of solubilizing multicomponent mixtures .
24114697	0	curcumin	32,40	VEGF	90,94	curcumin	VEGF	MESH:D003474	83785(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY study|nmod|effects injected|nmod|study injected|nsubj|profiles profiles|nmod|genes genes|appos|END_ENTITY	In vivo study on the effects of curcumin on the expression profiles of anti-tumour genes -LRB- VEGF , CyclinD1 and CDK4 -RRB- in liver of rats injected with DEN .
16491848	0	curcumin	21,29	WT1	33,36	curcumin	WT1	MESH:D003474	7490	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|compound|END_ENTITY	Inhibitory effect of curcumin on WT1 gene expression in patient leukemic cells .
18034345	0	curcumin	15,23	WT1	72,75	curcumin	WT1	MESH:D003474	7490	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of pure curcumin , demethoxycurcumin , and bisdemethoxycurcumin on WT1 gene expression in leukemic cell lines .
19196508	0	curcumin	42,50	WT1	22,25	curcumin	WT1	MESH:D003474	7490	Chemical	Gene	treatment|compound|START_ENTITY target|nmod|treatment tumour_gene_1|nmod|target tumour_gene_1|appos|END_ENTITY	Wilms ' _ tumour_gene_1 -LRB- WT1 -RRB- as a target in curcumin treatment of pancreatic_cancer cells .
21658388	0	curcumin	29,37	WT1	57,60	curcumin	WT1	MESH:D003474	7490	Chemical	Gene	START_ENTITY|nmod|expression expression|appos|END_ENTITY	Inhibitory mechanism of pure curcumin on Wilms ' _ tumor_1 -LRB- WT1 -RRB- gene expression through the PKCa signaling pathway in leukemic K562 cells .
22449094	0	curcumin	5,13	WT1	42,45	curcumin	WT1	MESH:D003474	7490	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|nmod|END_ENTITY	Pure curcumin decreases the expression of WT1 by upregulation of miR-15a and miR-16-1 in leukemic cells .
23106780	0	curcumin	84,92	acetylcholinesterase	60,80	curcumin	acetylcholinesterase	MESH:D003474	43	Chemical	Gene	studies|nmod|START_ENTITY studies|nmod|inhibition inhibition|nmod|END_ENTITY	Experimental and computational studies on the inhibition of acetylcholinesterase by curcumin and some of its derivatives .
23200738	0	curcumin	19,27	acetylcholinesterase	38,58	curcumin	acetylcholinesterase	MESH:D003474	83817(Tax:10116)	Chemical	Gene	Pre-treatment|nmod|START_ENTITY modulates|nsubj|Pre-treatment modulates|dobj|activity activity|amod|END_ENTITY	Pre-treatment with curcumin modulates acetylcholinesterase activity and proinflammatory cytokines in rats infected with Trypanosoma evansi .
26981003	0	curcumin	11,19	acetylcholinesterase	105,125	curcumin	acetylcholinesterase	MESH:D003474	11423(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of curcumin on the social behavior , blood composition , reproductive hormones in plasma and brain acetylcholinesterase in cadmium intoxicated mice .
18601853	0	curcumin	12,20	adiponectin	37,48	curcumin	adiponectin	MESH:D003474	9370	Chemical	Gene	START_ENTITY|nmod|secretion secretion|nmod|END_ENTITY	-LSB- Effects of curcumin on secretion of adiponectin and interleukin-6 in human adipose tissues : an in vitro study -RSB- .
25143335	0	curcumin	11,19	angiotensin-converting_enzyme	23,52	curcumin	angiotensin-converting enzyme	MESH:D003474	24310(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|amod|END_ENTITY	Effects of curcumin on angiotensin-converting_enzyme gene expression , oxidative stress and anti-oxidant status in thioacetamide-induced hepatotoxicity .
9698073	0	curcumin	10,18	aryl_hydrocarbon_receptor	26,51	curcumin	aryl hydrocarbon receptor	MESH:D003474	196	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of curcumin on the aryl_hydrocarbon_receptor and cytochrome_P450_1A1 in MCF-7 human breast_carcinoma cells .
21381747	0	curcumin	15,23	b-cyclodextrin	39,53	curcumin	b-cyclodextrin	MESH:D003474	285440	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of curcumin and bixin with b-cyclodextrin : complexation methods , stability , and applications in food .
23816368	0	curcumin	16,24	beta-catenin	74,86	curcumin	beta-catenin	MESH:D003474	84353(Tax:10116)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|nmod|END_ENTITY	The curry spice curcumin attenuates beta-amyloid-induced toxicity through beta-catenin and PI3K signaling in rat organotypic hippocampal slice culture .
19189206	0	curcumin	15,23	beta-lactoglobulin	71,89	curcumin	beta-lactoglobulin	MESH:D003474	280838(Tax:9913)	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of curcumin and diacetylcurcumin with the lipocalin member beta-lactoglobulin .
24476477	0	curcumin	11,19	brain-derived_neurotrophic_factor	23,56	curcumin	brain-derived neurotrophic factor	MESH:D003474	627	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|amod|END_ENTITY	Effects of curcumin on brain-derived_neurotrophic_factor levels and oxidative damage in obesity and diabetes .
26608718	0	curcumin	10,18	brain-derived_neurotrophic_factor	28,61	curcumin	brain-derived neurotrophic factor	MESH:D003474	627	Chemical	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	Effect of curcumin on serum brain-derived_neurotrophic_factor levels in women with premenstrual_syndrome : A randomized , double-blind , placebo-controlled trial .
24397136	0	curcumin	11,19	calcitionin_gene_related_peptide	23,55	curcumin	calcitionin gene related peptide	MESH:D003474	24241(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effect of curcumin on calcitionin_gene_related_peptide expression after spinal_cord_injury in rats -RSB- .
16276182	17	curcumin	2014,2022	caspase-3	1982,1991	curcumin	caspase-3	MESH:D003474	836	Chemical	Gene	induced|nmod|START_ENTITY activation|acl|induced activation|amod|END_ENTITY	In addition , inhibition of p38 mitogen-activated protein kinase with SB203580 suppressed apoptosis and caspase-3 activation induced by curcumin .
19457704	0	curcumin	115,123	connective_tissue_growth_factor	21,52	curcumin	connective tissue growth factor	MESH:D003474	1490	Chemical	Gene	Modulation|nmod|START_ENTITY production|dep|Modulation production|compound|END_ENTITY	Arecoline-stimulated connective_tissue_growth_factor production in human buccal mucosal fibroblasts : Modulation by curcumin .
11566484	0	curcumin	70,78	cyclooxygenase-2	23,39	curcumin	cyclooxygenase-2	MESH:D003474	5743	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Specific inhibition of cyclooxygenase-2 -LRB- COX-2 -RRB- expression by dietary curcumin in HT-29 human colon_cancer cells .
15683997	0	curcumin	28,36	cyclooxygenase-2	53,69	curcumin	cyclooxygenase-2	MESH:D003474	29527(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|amod|END_ENTITY	-LSB- Effects of combined use of curcumin and catechin on cyclooxygenase-2 mRNA expression in dimethylhydrazine-induced rat colon_carcinogenesis -RSB- .
16596191	0	curcumin	72,80	cyclooxygenase-2	43,59	curcumin	cyclooxygenase-2	MESH:D003474	5743	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Induction of G2/M arrest and inhibition of cyclooxygenase-2 activity by curcumin in human bladder_cancer T24 cells .
22113581	0	curcumin	2,10	cyclooxygenase-2	147,163	curcumin	cyclooxygenase-2	MESH:D003474	5743	Chemical	Gene	derivative|amod|START_ENTITY cyclohexanone|amod|derivative attenuates|nsubj|cyclohexanone attenuates|dobj|synthesis synthesis|nmod|suppression suppression|nmod|END_ENTITY	A curcumin derivative , 2,6-bis -LRB- 2,5-dimethoxybenzylidene -RRB- - cyclohexanone -LRB- BDMC33 -RRB- attenuates prostaglandin_E2 synthesis via selective suppression of cyclooxygenase-2 in IFN-y/LPS-stimulated macrophages .
16288784	0	curcumin	24,32	cytochrome_P450	94,109	curcumin	cytochrome P450	MESH:D003474	25251(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inactivation inactivation|nmod|END_ENTITY	Selective protection of curcumin against carbon_tetrachloride-induced inactivation of hepatic cytochrome_P450 isozymes in rats .
24316375	0	curcumin	41,49	dipeptidyl_peptidase_IV	68,91	curcumin	dipeptidyl peptidase IV	MESH:D003474	1803	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Evaluation of -LRB- arene -RRB- Ru -LRB- II -RRB- complexes of curcumin as inhibitors of dipeptidyl_peptidase_IV .
18301913	0	curcumin	71,79	erythropoietin	22,36	curcumin	erythropoietin	MESH:D003474	24335(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Synergistic effect of erythropoietin but not G-CSF in combination with curcumin on impaired liver_regeneration in rats .
26706937	0	curcumin	22,30	fetuin-A	56,64	curcumin	fetuin-A	MESH:D003474	25373(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|amod|END_ENTITY	The effect of dietary curcumin and capsaicin on hepatic fetuin-A expression and fat accumulation in rats fed on a high-fat diet .
15219947	0	curcumin	10,18	gelatinase_A	22,34	curcumin	gelatinase A	MESH:D003474	17390(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|compound|END_ENTITY	Effect of curcumin on gelatinase_A -LRB- MMP-2 -RRB- activity in B16F10 melanoma cells .
23336507	0	curcumin	85,93	glial_fibrillary_acidic_protein	123,154	curcumin	glial fibrillary acidic protein	MESH:D003474	24387(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Curcumin as a potential treatment for Alzheimer 's _ disease : a study of the effects of curcumin on hippocampal expression of glial_fibrillary_acidic_protein .
20071071	0	curcumin	11,19	glyoxalase_I	25,37	curcumin	glyoxalase I	MESH:D003474	2739	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of curcumin with glyoxalase_I : Molecular docking , molecular_dynamics simulations , and kinetics analysis .
18394334	0	curcumin	25,33	gp120	80,85	curcumin	gp120	MESH:D003474	155971(Tax:11676)	Chemical	Gene	Effect|nmod|START_ENTITY induced|nsubj|Effect induced|nmod|END_ENTITY	-LSB- Effect and mechanism of curcumin on learning and memory_dysfunction induced by gp120 in rats -RSB- .
17973899	0	curcumin	108,116	haem_oxygenase-1	12,28	curcumin	haem oxygenase-1	MESH:D003474	15368(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of haem_oxygenase-1 in the decrease of endothelial intercellular_adhesion_molecule-1 expression by curcumin .
11592943	0	curcumin	48,56	heme_oxygenase-1	13,29	curcumin	heme oxygenase-1	MESH:D003474	3162	Chemical	Gene	induction|nmod|START_ENTITY induction|nsubj|Mechanism Mechanism|nmod|gene gene|amod|END_ENTITY	Mechanism of heme_oxygenase-1 gene induction by curcumin in human renal proximal tubule cells .
12927811	0	curcumin	62,70	heme_oxygenase-1	32,48	curcumin	heme oxygenase-1	MESH:D003474	3162	Chemical	Gene	modulate|nmod|START_ENTITY modulate|dobj|induction induction|amod|END_ENTITY	Changes in temperature modulate heme_oxygenase-1 induction by curcumin in renal epithelial cells .
18325727	0	curcumin	78,86	heme_oxygenase-1	33,49	curcumin	heme oxygenase-1	MESH:D003474	15368(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nmod|effect	Involvement of anti-inflammatory heme_oxygenase-1 in the inhibitory effect of curcumin on the expression of pro-inflammatory inducible nitric_oxide synthase in RAW264 .7 macrophages .
24101950	0	curcumin	61,69	heme_oxygenase-1	120,136	curcumin	heme oxygenase-1	MESH:D003474	3162	Chemical	Gene	analogues|compound|START_ENTITY analogues|nmod|inducers inducers|nmod|END_ENTITY	Therapeutic roles of heme_oxygenase-1 in metabolic_diseases : curcumin and resveratrol analogues as possible inducers of heme_oxygenase-1 .
24101950	0	curcumin	61,69	heme_oxygenase-1	21,37	curcumin	heme oxygenase-1	MESH:D003474	3162	Chemical	Gene	analogues|compound|START_ENTITY roles|dep|analogues roles|nmod|END_ENTITY	Therapeutic roles of heme_oxygenase-1 in metabolic_diseases : curcumin and resveratrol analogues as possible inducers of heme_oxygenase-1 .
24592391	0	curcumin	41,49	heme_oxygenase-1	68,84	curcumin	heme oxygenase-1	MESH:D003474	3162	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY pharmacokinetics|nmod|expression expression|amod|END_ENTITY	Human pharmacokinetics of high dose oral curcumin and its effect on heme_oxygenase-1 expression in healthy male subjects .
24608370	0	curcumin	15,23	heme_oxygenase-1	81,97	curcumin	heme oxygenase-1	MESH:D003474	24451(Tax:10116)	Chemical	Gene	longa|appos|START_ENTITY decreases|nsubj|longa decreases|nmod|induction induction|amod|END_ENTITY	Curcuma longa -LRB- curcumin -RRB- decreases in vivo cisplatin-induced ototoxicity through heme_oxygenase-1 induction .
25211173	0	curcumin	10,18	heme_oxygenase_1	30,46	curcumin	heme oxygenase 1	MESH:D003474	24451(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of curcumin on hepatic heme_oxygenase_1 expression in high fat diet fed rats : is there a triangular relationship ?
15957838	0	curcumin	11,19	low_density_lipoprotein_receptors	43,76	curcumin	low density lipoprotein receptors	MESH:D003474	3949	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of curcumin on expression of human low_density_lipoprotein_receptors in Xenopus_Laevis oocytes -RSB- .
19944674	0	curcumin	105,113	maspin	23,29	curcumin	maspin	MESH:D003474	5268	Chemical	Gene	analysis|nmod|START_ENTITY analysis|nmod|END_ENTITY	Expression analysis of maspin in invasive_ductal_carcinoma of breast and modulation of its expression by curcumin in breast_cancer cell lines .
23933360	0	curcumin	9,17	matrix_metalloproteinase-9	149,175	curcumin	matrix metalloproteinase-9	MESH:D003474	81687(Tax:10116)	Chemical	Gene	START_ENTITY|acl:relcl|accelerates accelerates|advcl|decreasing decreasing|dobj|stress stress|nmod|END_ENTITY	Zinc -LRB- II -RRB- - curcumin accelerates the healing of acetic_acid-induced chronic gastric_ulcers in rats by decreasing oxidative stress and downregulation of matrix_metalloproteinase-9 .
17650800	0	curcumin	11,19	matrix_metalloproteinase_2	35,61	curcumin	matrix metalloproteinase 2	MESH:D003474	81686(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of curcumin on activity of matrix_metalloproteinase_2 , 9 and nuclear expression of RelA in rat hepatic stellate cells by activating peroxisome_proliferator-activated_receptor_gamma signal -RSB- .
26473373	0	curcumin	34,42	miR-21	93,99	curcumin	miR-21	MESH:D003474	406991	Chemical	Gene	resistance|compound|START_ENTITY resistance|acl|associated associated|nmod|expression expression|nmod|proteins proteins|amod|END_ENTITY	Migration-prone glioma cells show curcumin resistance associated with enhanced expression of miR-21 and invasion/anti-apoptosis-related proteins .
26734640	0	curcumin	55,63	miR-21	22,28	curcumin	miR-21	MESH:D003474	406991	Chemical	Gene	roles|nmod|START_ENTITY roles|nmod|END_ENTITY	The critical roles of miR-21 in anti-cancer effects of curcumin .
23761708	0	curcumin	88,96	multidrug_resistance_1	14,36	curcumin	multidrug resistance 1	MESH:D003474	5243	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|expression expression|amod|END_ENTITY	Modulation of multidrug_resistance_1 expression and function in retinoblastoma cells by curcumin .
15949703	0	curcumin	31,39	ornithine_decarboxylase	75,98	curcumin	ornithine decarboxylase	MESH:D003474	18263(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Suppressive effects of dietary curcumin on the increased activity of renal ornithine_decarboxylase in mice treated with a renal carcinogen , ferric_nitrilotriacetate .
8435870	0	curcumin	21,29	ornithine_decarboxylase	90,113	curcumin	ornithine decarboxylase	MESH:D003474	18263(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|mRNA mRNA|amod|END_ENTITY	Inhibitory effect of curcumin on 12-O-tetradecanoylphorbol-13-acetate-induced increase in ornithine_decarboxylase mRNA in mouse epidermis .
8993955	0	curcumin	155,163	ornithine_decarboxylase	37,60	curcumin	ornithine decarboxylase	MESH:D003474	18263(Tax:10090)	Chemical	Gene	evoked|nmod|START_ENTITY evoked|nsubj|effect effect|nmod|A A|nmod|induction induction|amod|END_ENTITY	Enhancing effect of ultraviolet A on ornithine_decarboxylase induction and dermatitis evoked by 12-o-tetradecanoylphorbol-13-acetate and its inhibition by curcumin in mouse skin .
18316600	0	curcumin	28,36	p21	0,3	curcumin	p21	MESH:D003474	1026	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	p21 Waf1/Cip1 expression by curcumin in U-87MG human glioma cells : role of early_growth_response-1 expression .
25966111	0	curcumin	10,18	p38MAPK	22,29	curcumin	p38MAPK	MESH:D003474	26416(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of curcumin on p38MAPK expression in DSS-induced murine ulcerative_colitis .
15809436	0	curcumin	122,130	p53	73,76	curcumin	p53	MESH:D003474	7157	Chemical	Gene	degradation|nmod|START_ENTITY degradation|compound|END_ENTITY	Inhibition of NAD -LRB- P -RRB- H : quinone_oxidoreductase_1 activity and induction of p53 degradation by the natural phenolic compound curcumin .
20727180	0	curcumin	119,127	p53	79,82	curcumin	p53	MESH:D003474	7157	Chemical	Gene	down-regulation|nmod|START_ENTITY independent|nsubj|down-regulation dependent|advcl|independent dependent|nmod|status status|compound|END_ENTITY	Nicotine-induced survival signaling in lung_cancer cells is dependent on their p53 status while its down-regulation by curcumin is independent .
21086748	0	curcumin	10,18	p53	75,78	curcumin	p53	MESH:D003474	101833915	Chemical	Gene	START_ENTITY|nmod|modulation modulation|nmod|pattern pattern|nmod|END_ENTITY	Effect of curcumin and ferulic_acid on modulation of expression pattern of p53 and bcl-2 proteins in 7,12-dimethylbenz -LSB- a -RSB- anthracene-induced hamster buccal pouch carcinogenesis .
21314329	0	curcumin	87,95	p53	16,19	curcumin	p53	MESH:D003474	7157	Chemical	Gene	Upregulation|nmod|START_ENTITY Upregulation|nmod|expression expression|compound|END_ENTITY	Upregulation of p53 expression in patients with colorectal_cancer by administration of curcumin .
23351311	0	curcumin	41,49	p53	53,56	curcumin	p53	MESH:D003474	7157	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Genistein abrogates G2 arrest induced by curcumin in p53 deficient T47D cells .
25789029	0	curcumin	37,45	p53	67,70	curcumin	p53	MESH:D003474	7157	Chemical	Gene	effect|nmod|START_ENTITY study|nmod|effect study|nmod|expression expression|nmod|protein protein|compound|END_ENTITY	A preliminary study of the effect of curcumin on the expression of p53 protein in a human multiple_myeloma cell line .
8989916	0	curcumin	91,99	p53	76,79	curcumin	p53	MESH:D003474	7157	Chemical	Gene	protein|nmod|START_ENTITY protein|compound|END_ENTITY	Induction of HSP70 gene expression by modulation of Ca -LRB- +2 -RRB- ion and cellular p53 protein by curcumin in colorectal_carcinoma cells .
21282056	0	curcumin	56,64	pancreatic_lipase	15,32	curcumin	pancreatic lipase	MESH:D003474	5406	Chemical	Gene	Enhancement|nmod|START_ENTITY Enhancement|nmod|activity activity|amod|END_ENTITY	Enhancement of pancreatic_lipase inhibitory activity of curcumin by radiolytic transformation .
27019802	0	curcumin	21,29	peroxisome_proliferator-activated_receptor-y	33,77	curcumin	peroxisome proliferator-activated receptor-y	MESH:D003474	5468	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Potential effects of curcumin on peroxisome_proliferator-activated_receptor-y in vitro and in vivo .
17531121	0	curcumin	11,19	peroxisome_proliferator-activated_receptor_gamma	23,71	curcumin	peroxisome proliferator-activated receptor gamma	MESH:D003474	25664(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effects of curcumin on peroxisome_proliferator-activated_receptor_gamma expression and nuclear translocation/redistribution in culture-activated rat hepatic stellate cells .
17650800	0	curcumin	11,19	peroxisome_proliferator-activated_receptor_gamma	140,188	curcumin	peroxisome proliferator-activated receptor gamma	MESH:D003474	25664(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|acl|activating activating|dobj|-RSB- -RSB-|amod|END_ENTITY	-LSB- Effect of curcumin on activity of matrix_metalloproteinase_2 , 9 and nuclear expression of RelA in rat hepatic stellate cells by activating peroxisome_proliferator-activated_receptor_gamma signal -RSB- .
23163860	0	curcumin	99,107	placenta_growth_factor	21,43	curcumin	placenta growth factor	MESH:D003474	5228	Chemical	Gene	modulation|nmod|START_ENTITY production|dep|modulation production|compound|END_ENTITY	Arecoline-stimulated placenta_growth_factor production in gingival epithelial cells : modulation by curcumin .
20503397	0	curcumin	51,59	prostate-specific_antigen	81,106	curcumin	prostate-specific antigen	MESH:D003474	354	Chemical	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	Combined inhibitory effects of soy isoflavones and curcumin on the production of prostate-specific_antigen .
22588934	0	curcumin	12,20	syndecan-4	24,34	curcumin	syndecan-4	MESH:D003474	24771(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|protein protein|amod|END_ENTITY	-LSB- Effects of curcumin on syndecan-4 protein and p44/42 mitogen-activated protein kinase expression in tumor_necrosis_factor-a-induced rat vascular smooth muscle cells in vitro -RSB- .
23744438	0	curcumin	51,59	thymic_stromal_lymphopoietin	19,47	curcumin	thymic stromal lymphopoietin	MESH:D003474	85480	Chemical	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|nmod|END_ENTITY	Down-regulation of thymic_stromal_lymphopoietin by curcumin .
21493726	0	curcumin	22,30	thymidine_phosphorylase	68,91	curcumin	thymidine phosphorylase	MESH:D003474	1890	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Synergistic effect of curcumin and cisplatin via down-regulation of thymidine_phosphorylase and excision_repair_cross-complementary_1 -LRB- ERCC1 -RRB- .
21973306	0	curcumin	51,59	thymidine_phosphorylase	115,138	curcumin	thymidine phosphorylase	MESH:D003474	1890	Chemical	Gene	cytotoxicity|nmod|START_ENTITY Enhancement|nmod|cytotoxicity results|nsubj|Enhancement results|nmod|down-regulation down-regulation|nmod|expression expression|compound|END_ENTITY	Enhancement of mitomycin_C-induced cytotoxicity by curcumin results from down-regulation of MKK1/2-ERK 1/2-mediated thymidine_phosphorylase expression .
9134658	0	curcumin	20,28	tissue_factor	49,62	curcumin	tissue factor	MESH:D003474	101909187	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|compound|END_ENTITY	The dietary pigment curcumin reduces endothelial tissue_factor gene expression by inhibiting binding of AP-1 to the DNA and activation of NF-kappa B .
24491024	0	curcumin	20,28	tumor_necrosis_factor-a	58,81	curcumin	tumor necrosis factor-a	MESH:D003474	21926(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Long-term effect of curcumin down-regulates expression of tumor_necrosis_factor-a and interleukin-6 via modulation of E26 transformation-specific protein and nuclear factor-kB transcription factors in livers of lymphoma bearing mice .
17662242	0	curcumin	10,18	vascular_endothelial_growth_factor	44,78	curcumin	vascular endothelial growth factor	MESH:D003474	83785(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of curcumin on hyperglycemia-induced vascular_endothelial_growth_factor expression in streptozotocin-induced diabetic rat retina .
21302394	0	curcumin	10,18	vascular_endothelial_growth_factor	22,56	curcumin	vascular endothelial growth factor	MESH:D003474	22339(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effect of curcumin on vascular_endothelial_growth_factor expression in diabetic_mice_kidney induced by streptozotocin .
18379992	0	curcumin	105,113	vascular_endothelial_growth_factor-A	16,52	curcumin	vascular endothelial growth factor-A	MESH:D003474	22339(Tax:10090)	Chemical	Gene	expression|acl|START_ENTITY expression|amod|END_ENTITY	CD147 regulates vascular_endothelial_growth_factor-A expression , tumorigenicity , and chemosensitivity to curcumin in hepatocellular_carcinoma .
8055654	0	curcumin	21,29	xanthine_dehydrogenase	33,55	curcumin	xanthine dehydrogenase	MESH:D003474	22436(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Inhibitory effect of curcumin on xanthine_dehydrogenase / oxidase induced by phorbol-12-myristate-13-acetate in NIH3T3 cells .
24689857	0	curcuminoids	30,42	FLT3	46,50	curcuminoids	FLT3	null	2322	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|compound|END_ENTITY	Inhibitory effect of turmeric curcuminoids on FLT3 expression and cell cycle arrest in the FLT3-overexpressing EoL-1 leukemic cell line .
18930076	0	curcuminoids	21,33	acetylcholinesterase	37,57	curcuminoids	acetylcholinesterase	null	83817(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Inhibitory effect of curcuminoids on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia may explain medicinal use of turmeric in Alzheimer 's _ disease .
16953118	0	curcuminoids	23,35	heme_oxygenase-1	51,67	curcuminoids	heme oxygenase-1	null	3162	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Comparative effects of curcuminoids on endothelial heme_oxygenase-1 expression : ortho-methoxy groups are essential to enhance heme oxygenase activity and protection .
20661707	0	curcuminoids	34,46	matrix_metalloproteinase-3	50,76	curcuminoids	matrix metalloproteinase-3	null	4314	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|amod|END_ENTITY	The inhibitory effect of turmeric curcuminoids on matrix_metalloproteinase-3 secretion in human invasive breast_carcinoma cells .
25616094	0	cutamesine_dihydrochloride	38,64	sigma-1_receptor	12,28	cutamesine dihydrochloride	sigma-1 receptor	null	18391(Tax:10090)	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Effect of a sigma-1_receptor agonist , cutamesine_dihydrochloride -LRB- SA4503 -RRB- , on photoreceptor cell death against light-induced damage .
3426683	0	cyanamide	14,23	ALDH	79,83	cyanamide	ALDH	MESH:D003484	25375(Tax:10116)	Chemical	Gene	Metabolism|nmod|START_ENTITY Metabolism|appos|END_ENTITY	Metabolism of cyanamide to cyanide and an inhibitor of aldehyde_dehydrogenase -LRB- ALDH -RRB- by rat liver microsomes .
6870943	0	cyanamide	124,133	aldehyde_dehydrogenase	64,86	cyanamide	aldehyde dehydrogenase	MESH:D003484	25375(Tax:10116)	Chemical	Gene	compounds|amod|START_ENTITY END_ENTITY|nmod|compounds	Studies in vitro on the inactivation of mitochondrial rat-liver aldehyde_dehydrogenase by the alcohol-sensitizing compounds cyanamide , 1-aminocyclopropanol and disulfiram .
23546291	0	cyanamide	11,20	aldehyde_dehydrogenase_type_2	25,54	cyanamide	aldehyde dehydrogenase type 2	MESH:D003484	100338523(Tax:9986)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effects of cyanamide , an aldehyde_dehydrogenase_type_2 inhibitor , on glyceryl_trinitrate - and isosorbide_dinitrate-induced vasodilation in rabbit excised aorta and in anesthetized whole animal .
4089878	0	cyanamide	108,117	catalase	42,50	cyanamide	catalase	MESH:D003484	847	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|activity activity|nmod|END_ENTITY	Inhibition of the peroxidatic activity of catalase towards alcohols by the aldehyde dehydrogenase inhibitor cyanamide .
6378202	0	cyanamide	28,37	catalase	96,104	cyanamide	catalase	MESH:D003484	24248(Tax:10116)	Chemical	Gene	dehydrogenase|amod|START_ENTITY activation|nmod|dehydrogenase catalyzed|nsubjpass|activation catalyzed|nmod|END_ENTITY	The metabolic activation of cyanamide to an inhibitor of aldehyde dehydrogenase is catalyzed by catalase .
8218960	0	cyanamide	84,93	mitochondrial_aldehyde_dehydrogenase	26,62	cyanamide	mitochondrial aldehyde dehydrogenase	MESH:D003484	29539(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY END_ENTITY|nmod|administration	Inhibition of rat hepatic mitochondrial_aldehyde_dehydrogenase isozymes by repeated cyanamide administration : pharmacokinetic-pharmacodynamic relationships .
15204430	0	cyanate	41,48	erythropoietin	14,28	cyanate	erythropoietin	CHEBI:29195	24335(Tax:10116)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activity activity|compound|END_ENTITY	Inhibition of erythropoietin activity by cyanate .
2519724	0	cyanide	79,86	cytochrome_P-450_IIE1_and_catalase	8,42	cyanide	cytochrome P-450 IIE1 and catalase	CHEBI:17514	24248(Tax:10116)	Chemical	Gene	Role|acl|START_ENTITY Role|nmod|END_ENTITY	Role of cytochrome_P-450_IIE1_and_catalase in the oxidation of acetonitrile to cyanide .
1847831	0	cyanide	32,39	myeloperoxidase	51,66	cyanide	myeloperoxidase	CHEBI:17514	4353	Chemical	Gene	complex|amod|START_ENTITY complex|nmod|END_ENTITY	Interaction of halides with the cyanide complex of myeloperoxidase : a model for substrate binding to compound I. EPR spectra of the low-spin cyanide complex of myeloperoxidase have been measured in the absence and presence of halide substrates ; chloride , bromide and iodide .
24768788	0	cyanide	16,23	neuroglobin	53,64	cyanide	neuroglobin	CHEBI:17514	58157	Chemical	Gene	complexes|amod|START_ENTITY complexes|nmod|END_ENTITY	EPR analysis of cyanide complexes of wild-type human neuroglobin and mutants in comparison to horse heart myoglobin .
20795898	0	cyanide	31,38	rhodanese	18,27	cyanide	rhodanese	CHEBI:17514	22117(Tax:10090)	Chemical	Gene	antagonism|amod|START_ENTITY END_ENTITY|nmod|antagonism	Nano-intercalated rhodanese in cyanide antagonism .
19192199	0	cyanidin-3-glucoside	43,63	rhodopsin	28,37	cyanidin-3-glucoside	rhodopsin	MESH:C114438	6010	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	pH-dependent interaction of rhodopsin with cyanidin-3-glucoside .
19267871	0	cyanidin-3-glucoside	43,63	rhodopsin	28,37	cyanidin-3-glucoside	rhodopsin	MESH:C114438	6010	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	pH-dependent interaction of rhodopsin with cyanidin-3-glucoside .
9708342	0	cyclaradine	15,26	adenosine_deaminase	30,49	cyclaradine	adenosine deaminase	MESH:C014387	100	Chemical	Gene	Deamination|nmod|START_ENTITY Deamination|nmod|END_ENTITY	Deamination of cyclaradine by adenosine_deaminase under high pressure .
15101710	0	cyclic-AMP	12,22	CREB	40,44	cyclic-AMP	CREB	MESH:D000242	1385	Chemical	Gene	protein|amod|START_ENTITY role|nmod|protein role|appos|END_ENTITY	The role of cyclic-AMP binding protein -LRB- CREB -RRB- in leukemia cell proliferation and acute_leukemias .
16110470	0	cyclic-AMP	8,18	CREB	47,51	cyclic-AMP	CREB	MESH:D000242	81646(Tax:10116)	Chemical	Gene	responsive|amod|START_ENTITY Role|nmod|responsive element|nsubj|Role element|dobj|proteins proteins|appos|END_ENTITY	Role of cyclic-AMP responsive element binding -LRB- CREB -RRB- proteins in cell proliferation in a rat model of hepatocellular_carcinoma .
9989941	0	cyclic-AMP	44,54	CREB	26,30	cyclic-AMP	CREB	MESH:D000242	81646(Tax:10116)	Chemical	Gene	element|amod|START_ENTITY binding|nmod|element binding|nsubj|END_ENTITY	Glucocorticoids stimulate CREB binding to a cyclic-AMP response element in the rat serine_dehydratase gene .
10403812	0	cyclic-AMP	70,80	NF1	21,24	cyclic-AMP	NF1	MESH:D000242	18015(Tax:10090)	Chemical	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Transcription factor NF1 mediates repression of the GLUT4 promoter by cyclic-AMP .
7706453	0	cyclic-AMP	14,24	c-myc	46,51	cyclic-AMP	c-myc	MESH:D000242	4609	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|regulation regulation|nmod|expression expression|amod|END_ENTITY	The effect of cyclic-AMP on the regulation of c-myc expression in T_lymphoma cells .
9757056	0	cyclic-AMP	45,55	preprosomatostatin	18,36	cyclic-AMP	preprosomatostatin	MESH:D000242	6750	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|gene gene|compound|END_ENTITY	Regulation of the preprosomatostatin gene by cyclic-AMP in cerebrocortical neurons .
9989941	0	cyclic-AMP	44,54	serine_dehydratase	83,101	cyclic-AMP	serine dehydratase	MESH:D000242	25044(Tax:10116)	Chemical	Gene	element|amod|START_ENTITY element|nmod|gene gene|compound|END_ENTITY	Glucocorticoids stimulate CREB binding to a cyclic-AMP response element in the rat serine_dehydratase gene .
9179304	0	cyclic-guanosine-monophosphate	48,78	atrial_natriuretic_factor	10,35	cyclic-guanosine-monophosphate	atrial natriuretic factor	null	24602(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of atrial_natriuretic_factor and fate of cyclic-guanosine-monophosphate in the rat kidney .
11062073	0	cyclic_ADP-ribose	26,43	Angiotensin_II	0,14	cyclic ADP-ribose	Angiotensin II	MESH:D036563	24179(Tax:10116)	Chemical	Gene	formation|amod|START_ENTITY stimulates|dobj|formation stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates cyclic_ADP-ribose formation in neonatal rat cardiac myocytes .
23940051	3	cyclic_ADP-ribose	543,560	CD38	627,631	cyclic ADP-ribose	CD38	MESH:D036563	12494(Tax:10090)	Chemical	Gene	START_ENTITY|acl:relcl|generated generated|nmod|cyclase cyclase|appos|END_ENTITY	One putative activator of the ryanodine receptor is the nucleotide second messenger cyclic_ADP-ribose -LRB- cADPR -RRB- , which is generated by an ectoenzyme ADP-ribosyl cyclase , CD38 .
7635203	0	cyclic_ADP-ribose	44,61	CD38	94,98	cyclic ADP-ribose	CD38	MESH:D036563	952	Chemical	Gene	bifunctional|amod|START_ENTITY bridges|nmod|bifunctional role|nmod|bridges ectoenzyme|nsubj|role ectoenzyme|dobj|END_ENTITY	Structural role of disulfide bridges in the cyclic_ADP-ribose related bifunctional ectoenzyme CD38 .
7961800	0	cyclic_ADP-ribose	32,49	CD38	78,82	cyclic ADP-ribose	CD38	MESH:D036563	952	Chemical	Gene	synthesis|amod|START_ENTITY cysteine|nmod|synthesis cysteine|nmod|END_ENTITY	Essential cysteine residues for cyclic_ADP-ribose synthesis and hydrolysis by CD38 .
8235624	0	cyclic_ADP-ribose	28,45	CD38	78,82	cyclic ADP-ribose	CD38	MESH:D036563	12494(Tax:10090)	Chemical	Gene	Formation|nmod|START_ENTITY catalyzed|nsubj|Formation catalyzed|nmod|END_ENTITY	Formation and hydrolysis of cyclic_ADP-ribose catalyzed by lymphocyte antigen CD38 .
9148900	0	cyclic_ADP-ribose	128,145	CD38	0,4	cyclic ADP-ribose	CD38	MESH:D036563	952	Chemical	Gene	activity|nmod|START_ENTITY potentiates|dobj|activity ADP-ribose|acl:relcl|potentiates synthesis|nmod|ADP-ribose catalyze|dobj|synthesis catalyze|nsubj|END_ENTITY	CD38 and ADP-ribosyl_cyclase catalyze the synthesis of a dimeric ADP-ribose that potentiates the calcium-mobilizing activity of cyclic_ADP-ribose .
9890936	0	cyclic_ADP-ribose	53,70	CD38	0,4	cyclic ADP-ribose	CD38	MESH:D036563	12494(Tax:10090)	Chemical	Gene	impairs|nmod|START_ENTITY impairs|nsubj|disruption disruption|compound|END_ENTITY	CD38 disruption impairs glucose-induced increases in cyclic_ADP-ribose , -LSB- Ca2 + -RSB- i , and insulin secretion .
16601673	0	cyclic_ADP-ribose	20,37	TRPM2	0,5	cyclic ADP-ribose	TRPM2	MESH:D036563	28240(Tax:10090)	Chemical	Gene	activation|nmod|START_ENTITY activation|nummod|END_ENTITY	TRPM2 activation by cyclic_ADP-ribose at body temperature is involved in insulin secretion .
8663443	0	cyclic_ADP-ribose	75,92	type_2_ryanodine_receptor	4,29	cyclic ADP-ribose	type 2 ryanodine receptor	MESH:D036563	689560(Tax:10116)	Chemical	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	The type_2_ryanodine_receptor of neurosecretory PC12 cells is activated by cyclic_ADP-ribose .
24763878	0	cyclic_AMP	93,103	ABCA1	68,73	cyclic AMP	ABCA1	MESH:D000242	19	Chemical	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Angiotensin - -LRB- 1-7 -RRB- upregulates -LRB- ATP-binding_cassette_transporter_A1 -RRB- ABCA1 expression through cyclic_AMP signaling pathway in RAW 264.7 macrophages .
7623612	0	cyclic_AMP	25,35	Adrenomedullin	0,14	cyclic AMP	Adrenomedullin	MESH:D000242	25026(Tax:10116)	Chemical	Gene	increases|dobj|START_ENTITY increases|nsubj|END_ENTITY	Adrenomedullin increases cyclic_AMP more potently than CGRP and amylin in rat renal tubular basolateral membranes .
8166740	0	cyclic_AMP	26,36	Adrenomedullin	0,14	cyclic AMP	Adrenomedullin	MESH:D000242	25026(Tax:10116)	Chemical	Gene	formation|compound|START_ENTITY stimulates|dobj|formation stimulates|nsubj|END_ENTITY	Adrenomedullin stimulates cyclic_AMP formation in rat vascular smooth muscle cells .
9428729	0	cyclic_AMP	81,91	Adrenomedullin	0,14	cyclic AMP	Adrenomedullin	MESH:D000242	133	Chemical	Gene	involvement|nmod|START_ENTITY effects|dep|involvement has|dobj|effects has|nsubj|END_ENTITY	Adrenomedullin has mitogenic effects on human oral keratinocytes : involvement of cyclic_AMP .
26180185	0	cyclic_AMP	73,83	Aldo-keto_reductase_1b7	0,23	cyclic AMP	Aldo-keto reductase 1b7	MESH:D000242	11997(Tax:10090)	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Aldo-keto_reductase_1b7 , a novel marker for renin cells , is regulated by cyclic_AMP signaling .
2443404	0	cyclic_AMP	43,53	Angiotensin_converting_enzyme	0,29	cyclic AMP	Angiotensin converting enzyme	MESH:D000242	509484(Tax:9913)	Chemical	Gene	induction|nmod|START_ENTITY induction|nsubj|END_ENTITY	Angiotensin_converting_enzyme induction by cyclic_AMP and analogues in cultured endothelial cells .
7528289	0	cyclic_AMP	35,45	Atrial_natriuretic_peptide	0,26	cyclic AMP	Atrial natriuretic peptide	MESH:D000242	281355(Tax:9913)	Chemical	Gene	reduces|dobj|START_ENTITY reduces|nsubj|END_ENTITY	Atrial_natriuretic_peptide reduces cyclic_AMP by activating cyclic_GMP-stimulated_phosphodiesterase in vascular endothelial cells .
1284620	0	cyclic_AMP	25,35	Bradykinin	0,10	cyclic AMP	Bradykinin	MESH:D000242	3827	Chemical	Gene	accumulation|compound|START_ENTITY inhibition|nmod|accumulation inhibition|compound|END_ENTITY	Bradykinin inhibition of cyclic_AMP accumulation in D384 astrocytoma cells .
7688545	0	cyclic_AMP	20,30	Bradykinin	0,10	cyclic AMP	Bradykinin	MESH:D000242	3827	Chemical	Gene	accumulation|compound|START_ENTITY inhibits|dobj|accumulation inhibits|nsubj|END_ENTITY	Bradykinin inhibits cyclic_AMP accumulation in D384-human astrocytoma cells via a calcium-dependent inhibition of adenylyl cyclase .
7887933	0	cyclic_AMP	59,69	C5a_receptor	37,49	cyclic AMP	C5a receptor	MESH:D000242	728	Chemical	Gene	accumulation|compound|START_ENTITY inhibits|dobj|accumulation inhibits|nsubj|END_ENTITY	The human chemoattractant complement C5a_receptor inhibits cyclic_AMP accumulation through Gi and Gz proteins .
8864528	0	cyclic_AMP	18,28	CD4	68,71	cyclic AMP	CD4	MESH:D000242	920	Chemical	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Identification of cyclic_AMP phosphodiesterases 3 , 4 and 7 in human CD4 + and CD8 + T-lymphocytes : role in regulating proliferation and the biosynthesis of interleukin-2 .
10087189	0	cyclic_AMP	34,44	CD40L	14,19	cyclic AMP	CD40L	MESH:D000242	959	Chemical	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Regulation of CD40L expression by cyclic_AMP : contrasting proinflammatory and inhibitory actions .
2468994	0	cyclic_AMP	159,169	CG_beta	143,150	cyclic AMP	CG beta	MESH:D000242	1082	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Isolation and characterization of the human chorionic_gonadotropin_beta_subunit -LRB- CG_beta -RRB- gene cluster : regulation of transcriptionally active CG_beta gene by cyclic_AMP .
2468994	0	cyclic_AMP	159,169	CG_beta	81,88	cyclic AMP	CG beta	MESH:D000242	1082	Chemical	Gene	gene|nmod|START_ENTITY regulation|nmod|gene Isolation|dep|regulation Isolation|nmod|chorionic_gonadotropin_beta_subunit chorionic_gonadotropin_beta_subunit|appos|END_ENTITY	Isolation and characterization of the human chorionic_gonadotropin_beta_subunit -LRB- CG_beta -RRB- gene cluster : regulation of transcriptionally active CG_beta gene by cyclic_AMP .
1453687	0	cyclic_AMP	30,40	CRE-BP1	19,26	cyclic AMP	CRE-BP1	MESH:D000242	1386	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	Phosphorylation of CRE-BP1 , a cyclic_AMP response element binding protein , by protein kinase C and cyclic_AMP-dependent protein kinase .
1829805	0	cyclic_AMP	67,77	CRE-BP1	18,25	cyclic AMP	CRE-BP1	MESH:D000242	1386	Chemical	Gene	element|compound|START_ENTITY binding|nmod|element regulator|amod|binding regulator|amod|transcriptional transcriptional|amod|END_ENTITY	Expression of the CRE-BP1 transcriptional regulator binding to the cyclic_AMP response element in central nervous system , regenerating liver , and human tumors .
2145272	0	cyclic_AMP	96,106	CRE-BP1	29,36	cyclic AMP	CRE-BP1	MESH:D000242	1386	Chemical	Gene	element|compound|START_ENTITY binding|nmod|element regulator|amod|binding encoding|dobj|regulator region|acl|encoding region|nmod|gene gene|compound|END_ENTITY	Promoter region of the human CRE-BP1 gene encoding the transcriptional regulator binding to the cyclic_AMP response element .
2529117	0	cyclic_AMP	63,73	CRE-BP1	40,47	cyclic AMP	CRE-BP1	MESH:D000242	1386	Chemical	Gene	element|compound|START_ENTITY binding|nmod|element structure|amod|binding structure|nmod|END_ENTITY	Leucine zipper structure of the protein CRE-BP1 binding to the cyclic_AMP response element in brain .
10535767	0	cyclic_AMP	88,98	CREB	0,4	cyclic AMP	CREB	MESH:D000242	81646(Tax:10116)	Chemical	Gene	II|amod|START_ENTITY involvement|nmod|II phosphorylation|dep|involvement phosphorylation|compound|END_ENTITY	CREB phosphorylation and melatonin biosynthesis in the rat pineal gland : involvement of cyclic_AMP dependent protein kinase type II .
10536364	0	cyclic_AMP	135,145	CREB	0,4	cyclic AMP	CREB	MESH:D000242	1385	Chemical	Gene	mediate|nmod|START_ENTITY mediate|nsubj|END_ENTITY	CREB and COUP-TF mediate transcriptional activation of the human_immunodeficiency_virus_type_1 genome in Jurkat T cells in response to cyclic_AMP and dopamine .
11457657	0	cyclic_AMP	15,25	CREB	60,64	cyclic AMP	CREB	MESH:D000242	1385	Chemical	Gene	response|compound|START_ENTITY Involvement|nmod|response element|nsubj|Involvement element|dobj|protein protein|appos|END_ENTITY	Involvement of cyclic_AMP response element binding protein -LRB- CREB -RRB- and estrogen receptor phosphorylation in the synergistic activation of the estrogen receptor by estradiol and protein kinase activators .
11504868	0	cyclic_AMP	62,72	CREB	106,110	cyclic AMP	CREB	MESH:D000242	1385	Chemical	Gene	response|compound|START_ENTITY preferences|nmod|response control|nmod|preferences element-binding|nsubj|control element-binding|dobj|END_ENTITY	Electrostatic control of half-site spacing preferences by the cyclic_AMP response element-binding protein CREB .
11514088	0	cyclic_AMP	29,39	CREB	74,78	cyclic AMP	CREB	MESH:D000242	81646(Tax:10116)	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Increased phosphorylation of cyclic_AMP response element-binding protein -LRB- CREB -RRB- in the superficial dorsal horn neurons following partial sciatic nerve ligation .
11599000	0	cyclic_AMP	10,20	CREB	186,190	cyclic AMP	CREB	MESH:D000242	1385	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|involvement involvement|nmod|END_ENTITY	Effect of cyclic_AMP on the expression of myelin_basic_protein species and myelin proteolipid protein in committed oligodendrocytes : differential involvement of the transcription factor CREB .
12110665	0	cyclic_AMP	11,21	CREB	56,60	cyclic AMP	CREB	MESH:D000242	39682(Tax:7227)	Chemical	Gene	response|compound|START_ENTITY role|nmod|response element-binding|nsubj|role element-binding|dobj|protein protein|appos|END_ENTITY	A role for cyclic_AMP response element-binding protein -LRB- CREB -RRB- but not the highly similar ATF-2 protein in sterol regulation of the promoter for 3-hydroxy-3-methylglutaryl_coenzyme_A reductase .
12773552	0	cyclic_AMP	44,54	CREB	138,142	cyclic AMP	CREB	MESH:D000242	1385	Chemical	Gene	regulation|amod|START_ENTITY calcium|nmod|regulation Synergism|nmod|calcium requires|nsubj|Synergism requires|dobj|cooperation cooperation|nmod|END_ENTITY	Synergism between calcium and cyclic_GMP in cyclic_AMP response element-dependent transcriptional regulation requires cooperation between CREB and C/EBP-beta .
1531356	0	cyclic_AMP	14,24	CREB	59,63	cyclic AMP	CREB	MESH:D000242	81646(Tax:10116)	Chemical	Gene	protein|compound|START_ENTITY Regulation|nmod|protein Regulation|appos|END_ENTITY	Regulation of cyclic_AMP response element-binding protein -LRB- CREB -RRB- phosphorylation by acute and chronic morphine in the rat locus coeruleus .
15663480	0	cyclic_AMP	58,68	CREB	103,107	cyclic AMP	CREB	MESH:D000242	12912(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|response response|dep|protein protein|appos|END_ENTITY	Role of basic region leucine zipper transcription factors cyclic_AMP response element binding protein -LRB- CREB -RRB- , CREB2 , activating_transcription_factor_2 and CAAT/enhancer _ binding_protein alpha in cyclic_AMP response element-mediated transcription .
16103063	0	cyclic_AMP	65,75	CREB	76,80	cyclic AMP	CREB	MESH:D000242	1385	Chemical	Gene	activation|nmod|START_ENTITY linked|nmod|activation oncogene|acl|linked oncogene|parataxis|regulated regulated|nsubj|END_ENTITY	Mect1-Maml2 fusion oncogene linked to the aberrant activation of cyclic_AMP / CREB regulated genes .
16207717	0	cyclic_AMP	14,24	CREB	59,63	cyclic AMP	CREB	MESH:D000242	1385	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Mitochondrial cyclic_AMP response element-binding protein -LRB- CREB -RRB- mediates mitochondrial gene expression and neuronal survival .
16417577	0	cyclic_AMP	19,29	CREB	66,70	cyclic AMP	CREB	MESH:D000242	12912(Tax:10090)	Chemical	Gene	attenuates|dobj|START_ENTITY attenuates|nsubj|protein protein|appos|END_ENTITY	Galanin attenuates cyclic_AMP regulatory element-binding protein -LRB- CREB -RRB- phosphorylation induced by chronic morphine and naloxone challenge in Cath.a cells and primary striatal cultures .
17277356	0	cyclic_AMP	37,47	CREB	82,86	cyclic AMP	CREB	MESH:D000242	12912(Tax:10090)	Chemical	Gene	response|compound|START_ENTITY response|dep|protein protein|appos|END_ENTITY	Glycogen synthase kinase-3 represses cyclic_AMP response element-binding protein -LRB- CREB -RRB- - targeted immediate early genes in quiescent cells .
18001288	0	cyclic_AMP	43,53	CREB	88,92	cyclic AMP	CREB	MESH:D000242	1385	Chemical	Gene	response|compound|START_ENTITY phosphorylation|nmod|response Restoration|nmod|phosphorylation element-binding|nsubj|Restoration element-binding|dobj|protein protein|appos|END_ENTITY	Restoration of impaired phosphorylation of cyclic_AMP response element-binding protein -LRB- CREB -RRB- by EGb_761 and its constituents in Abeta-expressing neuroblastoma cells .
18086876	0	cyclic_AMP	135,145	CREB	187,191	cyclic AMP	CREB	MESH:D000242	81646(Tax:10116)	Chemical	Gene	response|compound|START_ENTITY coordinated|nmod|response coordinated|dobj|protein protein|appos|END_ENTITY	Glucose-dependent_insulinotropic_polypeptide-mediated up-regulation of beta-cell antiapoptotic Bcl-2 gene expression is coordinated by cyclic_AMP -LRB- cAMP -RRB- response element binding protein -LRB- CREB -RRB- and cAMP-responsive CREB coactivator 2 .
19285017	0	cyclic_AMP	27,37	CREB	19,23	cyclic AMP	CREB	MESH:D000242	81646(Tax:10116)	Chemical	Gene	responsive|advmod|START_ENTITY protein|amod|responsive END_ENTITY|appos|protein	Phosphorylation of CREB , a cyclic_AMP responsive element binding protein , contributes partially to lysophosphatidic_acid-induced fibroblast cell proliferation .
19898718	0	cyclic_AMP	14,24	CREB	59,63	cyclic AMP	CREB	MESH:D000242	1385	Chemical	Gene	protein|compound|START_ENTITY Activation|nmod|protein Activation|appos|END_ENTITY	Activation of cyclic_AMP response element-binding protein -LRB- CREB -RRB- in aggressive_periodontal_disease .
2136830	0	cyclic_AMP	61,71	CREB	98,102	cyclic AMP	CREB	MESH:D000242	1385	Chemical	Gene	element|compound|START_ENTITY domain|nmod|element domain|dep|protein protein|appos|END_ENTITY	Both the basic region and the ` leucine zipper ' domain of the cyclic_AMP response element binding -LRB- CREB -RRB- protein are essential for transcriptional activation .
23182882	0	cyclic_AMP	56,66	CREB	103,107	cyclic AMP	CREB	MESH:D000242	12912(Tax:10090)	Chemical	Gene	gene|nmod|START_ENTITY regulation|nmod|gene responsive|nsubj|regulation responsive|dobj|protein protein|appos|END_ENTITY	Transcriptional regulation of mouse neuroglobin gene by cyclic_AMP responsive element binding protein -LRB- CREB -RRB- in N2a cells .
2320002	0	cyclic_AMP	19,29	CREB	86,90	cyclic AMP	CREB	MESH:D000242	1385	Chemical	Gene	response|compound|START_ENTITY cDNA|nmod|response element-binding|nsubj|cDNA element-binding|dobj|protein protein|acl:relcl|distinct distinct|nmod|END_ENTITY	A cDNA for a human cyclic_AMP response element-binding protein which is distinct from CREB and expressed preferentially in brain .
24145027	0	cyclic_AMP	96,106	CREB	141,145	cyclic AMP	CREB	MESH:D000242	12912(Tax:10090)	Chemical	Gene	protein|compound|START_ENTITY expression|nmod|protein expression|appos|END_ENTITY	Presenilins regulate neurotrypsin gene expression and neurotrypsin-dependent agrin cleavage via cyclic_AMP response element-binding protein -LRB- CREB -RRB- modulation .
24327051	0	cyclic_AMP	4,14	CREB	49,53	cyclic AMP	CREB	MESH:D000242	1385	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	The cyclic_AMP response element-binding protein -LRB- CREB -RRB- mediates smooth muscle cell proliferation in response to angiotensin_II .
7528813	0	cyclic_AMP	17,27	CREB	78,82	cyclic AMP	CREB	MESH:D000242	81646(Tax:10116)	Chemical	Gene	protein|compound|START_ENTITY protein|dep|member member|nmod|family family|compound|END_ENTITY	Oligodendroglial cyclic_AMP response element-binding protein : a member of the CREB family of transcription factors .
7912577	0	cyclic_AMP	77,87	CREB	27,31	cyclic AMP	CREB	MESH:D000242	1385	Chemical	Gene	promoter|nmod|START_ENTITY site|nmod|promoter site|compound|END_ENTITY	Effects of mutation of the CREB binding site of the somatostatin promoter on cyclic_AMP responsiveness in CV-1 cells .
8125987	0	cyclic_AMP	12,22	CREB	57,61	cyclic AMP	CREB	MESH:D000242	1385	Chemical	Gene	response|compound|START_ENTITY response|acl:relcl|phosphorylated phosphorylated|nsubj|protein protein|appos|END_ENTITY	Recombinant cyclic_AMP response element binding protein -LRB- CREB -RRB- phosphorylated on Ser-133 is transcriptionally active upon its introduction into fibroblast nuclei .
8627337	0	cyclic_AMP	36,46	CREB	30,34	cyclic AMP	CREB	MESH:D000242	12912(Tax:10090)	Chemical	Gene	protein|amod|START_ENTITY expression|appos|protein expression|compound|END_ENTITY	Transcriptional regulation of CREB -LRB- cyclic_AMP response element-binding protein -RRB- expression in CATH.a cells .
8645191	0	cyclic_AMP	53,63	CREB	118,122	cyclic AMP	CREB	MESH:D000242	1385	Chemical	Gene	gene|nmod|START_ENTITY induction|nmod|gene requires|nsubj|induction requires|ccomp|cyclic_AMP cyclic_AMP|xcomp|binding binding|nsubj|protein protein|appos|END_ENTITY	Transcriptional induction of the human renin gene by cyclic_AMP requires cyclic_AMP response element-binding protein -LRB- CREB -RRB- and a factor binding a pituitary-specific trans-acting factor -LRB- Pit-1 -RRB- motif .
8645191	0	cyclic_AMP	73,83	CREB	118,122	cyclic AMP	CREB	MESH:D000242	1385	Chemical	Gene	START_ENTITY|xcomp|binding binding|nsubj|protein protein|appos|END_ENTITY	Transcriptional induction of the human renin gene by cyclic_AMP requires cyclic_AMP response element-binding protein -LRB- CREB -RRB- and a factor binding a pituitary-specific trans-acting factor -LRB- Pit-1 -RRB- motif .
8999953	0	cyclic_AMP	51,61	CREB	150,154	cyclic AMP	CREB	MESH:D000242	1385	Chemical	Gene	Transactivation|nmod|START_ENTITY Transactivation|parataxis|kinase kinase|ccomp|mediated mediated|nmod|cAMP-responsive_element_binding_protein-1 cAMP-responsive_element_binding_protein-1|appos|END_ENTITY	Transactivation of the human renin promoter by the cyclic_AMP / protein kinase A pathway is mediated by both cAMP-responsive_element_binding_protein-1 -LRB- CREB -RRB- - dependent and CREB-independent mechanisms in Calu-6 cells .
9802424	0	cyclic_AMP	33,43	CREB	139,143	cyclic AMP	CREB	MESH:D000242	1385	Chemical	Gene	element|compound|START_ENTITY containing|dobj|element genes|acl|containing genes|dep|involvement involvement|nmod|END_ENTITY	NPY upregulates genes containing cyclic_AMP response element in human neuroblastoma cell lines bearing Y1 and Y2 receptors : involvement of CREB .
200121	0	cyclic_AMP	62,72	CSF	107,110	cyclic AMP	CSF	MESH:D000242	1437	Chemical	Gene	metabolites|compound|START_ENTITY metabolites|nmod|END_ENTITY	Alcohol , sleep and cerebrospinal fluid changes in alcoholics : cyclic_AMP and biogenic amine metabolites in CSF .
1665896	0	cyclic_AMP	47,57	Calcitonin_gene-related_peptide	0,31	cyclic AMP	Calcitonin gene-related peptide	MESH:D000242	24241(Tax:10116)	Chemical	Gene	responses|compound|START_ENTITY END_ENTITY|dep|responses	Calcitonin_gene-related_peptide -LRB- CGRP -RRB- - induced cyclic_AMP , cyclic_GMP and vasorelaxant responses in rat thoracic aorta are antagonized by blockers of endothelium-derived relaxant factor -LRB- EDRF -RRB- .
1724683	0	cyclic_AMP	68,78	Calcitonin_gene-related_peptide	0,31	cyclic AMP	Calcitonin gene-related peptide	MESH:D000242	24241(Tax:10116)	Chemical	Gene	responses|compound|START_ENTITY causes|dobj|responses causes|nsubj|END_ENTITY	Calcitonin_gene-related_peptide -LRB- CGRP -RRB- causes endothelium-dependent cyclic_AMP , cyclic_GMP and vasorelaxant responses in rat abdominal aorta .
3015365	0	cyclic_AMP	75,85	Calcitonin_gene-related_peptide	0,31	cyclic AMP	Calcitonin gene-related peptide	MESH:D000242	24241(Tax:10116)	Chemical	Gene	formation|compound|START_ENTITY calcitonin|nmod|formation acts|nmod|calcitonin acts|nsubj|END_ENTITY	Calcitonin_gene-related_peptide -LRB- CGRP -RRB- acts independently of calcitonin on cyclic_AMP formation in clonal osteogenic_sarcoma cells -LRB- UMR 106-01 -RRB- .
3036493	0	cyclic_AMP	41,51	Calcitonin_gene-related_peptide	0,31	cyclic AMP	Calcitonin gene-related peptide	MESH:D000242	396256(Tax:9031)	Chemical	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	Calcitonin_gene-related_peptide elevates cyclic_AMP levels in chick skeletal muscle : possible neurotrophic_role for a coexisting neuronal messenger .
8008632	0	cyclic_AMP	42,52	Corticotropin-releasing_factor	0,30	cyclic AMP	Corticotropin-releasing factor	MESH:D000242	1392	Chemical	Gene	stimulates|dobj|START_ENTITY stimulates|nsubj|END_ENTITY	Corticotropin-releasing_factor stimulates cyclic_AMP , arachidonic_acid release , and growth of lung_cancer cells .
11095985	0	cyclic_AMP	93,103	Cyclooxygenase-2	0,16	cyclic AMP	Cyclooxygenase-2	MESH:D000242	5743	Chemical	Gene	modulated|nmod|START_ENTITY modulated|nsubjpass|expression expression|amod|END_ENTITY	Cyclooxygenase-2 expression in lipopolysaccharide-stimulated human monocytes is modulated by cyclic_AMP , prostaglandin_E -LRB- 2 -RRB- , and nonsteroidal anti-inflammatory drugs .
14517215	0	cyclic_AMP	106,116	Cyclooxygenase-2	0,16	cyclic AMP	Cyclooxygenase-2	MESH:D000242	5743	Chemical	Gene	element|compound|START_ENTITY mediated|nmod|element mediated|nsubjpass|induction induction|amod|END_ENTITY	Cyclooxygenase-2 induction by bradykinin in human pulmonary artery smooth muscle cells is mediated by the cyclic_AMP response element through a novel autocrine loop involving endogenous prostaglandin_E2 , E-prostanoid_2 -LRB- EP2 -RRB- , and EP4 receptors .
15963501	0	cyclic_AMP	155,165	EPAC	167,171	cyclic AMP	EPAC	MESH:D000242	10411	Chemical	Gene	pathways|amod|START_ENTITY pathways|appos|END_ENTITY	Elevation of cyclic_AMP in Jurkat T-cells provokes distinct transcriptional responses through the protein kinase A -LRB- PKA -RRB- and exchange protein activated by cyclic_AMP -LRB- EPAC -RRB- pathways .
22276201	0	cyclic_AMP	103,113	EPAC	115,119	cyclic AMP	EPAC	MESH:D000242	10411	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	A fluorescence-based high-throughput assay for the discovery of exchange protein directly activated by cyclic_AMP -LRB- EPAC -RRB- antagonists .
26388312	0	cyclic_AMP	39,49	EPAC	51,55	cyclic AMP	EPAC	MESH:D000242	10411	Chemical	Gene	activation|compound|START_ENTITY activation|appos|END_ENTITY	Exchange protein directly activated by cyclic_AMP -LRB- EPAC -RRB- activation reverses neutrophil_dysfunction induced by b2-agonists , corticosteroids , and critical_illness .
26388312	0	cyclic_AMP	39,49	EPAC	51,55	cyclic AMP	EPAC	MESH:D000242	10411	Chemical	Gene	activation|compound|START_ENTITY activation|appos|END_ENTITY	Exchange protein directly activated by cyclic_AMP -LRB- EPAC -RRB- activation reverses neutrophil_dysfunction induced by b2-agonists , corticosteroids , and critical_illness .
10706951	0	cyclic_AMP	45,55	Endothelin-1	0,12	cyclic AMP	Endothelin-1	MESH:D000242	24323(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY increases|dobj|levels increases|nsubj|END_ENTITY	Endothelin-1 increases isoprenaline-enhanced cyclic_AMP levels in cerebral cortex .
9853756	0	cyclic_AMP	72,82	Epac	0,4	cyclic AMP	Epac	MESH:D000242	10411	Chemical	Gene	activated|nmod|START_ENTITY factor|acl|activated factor|nsubj|END_ENTITY	Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic_AMP .
19739231	0	cyclic_AMP	30,40	Epac2	44,49	cyclic AMP	Epac2	MESH:D000242	11069	Chemical	Gene	activated|nmod|START_ENTITY protein|acl|activated protein|appos|END_ENTITY	Exchange protein activated by cyclic_AMP 2 -LRB- Epac2 -RRB- plays a specific and time-limited role in memory retrieval .
2173084	0	cyclic_AMP	34,44	Epidermal_growth_factor	0,23	cyclic AMP	Epidermal growth factor	MESH:D000242	25313(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY increases|dobj|levels increases|nsubj|END_ENTITY	Epidermal_growth_factor increases cyclic_AMP levels in pregnant rat mammary gland explants .
8383515	0	cyclic_AMP	96,106	Epidermal_growth_factor	0,23	cyclic AMP	Epidermal growth factor	MESH:D000242	25313(Tax:10116)	Chemical	Gene	accumulation|compound|START_ENTITY produces|nmod|accumulation produces|nsubj|END_ENTITY	Epidermal_growth_factor produces inotropic and chronotropic effects in rat hearts by increasing cyclic_AMP accumulation .
10940479	0	cyclic_AMP	16,26	Ets2	8,12	cyclic AMP	Ets2	MESH:D000242	2114	Chemical	Gene	regulation|compound|START_ENTITY END_ENTITY|nmod|regulation	Role of Ets2 in cyclic_AMP regulation of the human chorionic gonadotropin beta promoter .
7696581	0	cyclic_AMP	78,88	GAP-43	5,11	cyclic AMP	GAP-43	MESH:D000242	2596	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|compound|END_ENTITY	B-50 / GAP-43 mRNA expression in cultured primary Schwann cells is regulated by cyclic_AMP .
16166624	0	cyclic_AMP	48,58	GCMa	15,19	cyclic AMP	GCMa	MESH:D000242	8521	Chemical	Gene	Stimulation|nmod|START_ENTITY Stimulation|nmod|activity activity|compound|END_ENTITY	Stimulation of GCMa transcriptional activity by cyclic_AMP / protein kinase A signaling is attributed to CBP-mediated acetylation of GCMa .
2465997	0	cyclic_AMP	40,50	GFAP	20,24	cyclic AMP	GFAP	MESH:D000242	2670	Chemical	Gene	mechanisms|compound|START_ENTITY END_ENTITY|nmod|mechanisms	Astrocytes regulate GFAP mRNA levels by cyclic_AMP and protein kinase C-dependent mechanisms .
8037665	0	cyclic_AMP	70,80	GLUT5	60,65	cyclic AMP	GLUT5	MESH:D000242	6518	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of expression of the human fructose transporter -LRB- GLUT5 -RRB- by cyclic_AMP .
19447893	0	cyclic_AMP	70,80	GTP_cyclohydrolase_I	0,20	cyclic AMP	GTP cyclohydrolase I	MESH:D000242	2643	Chemical	Gene	role|nmod|START_ENTITY nitric_oxide|dep|role regulated|nmod|nitric_oxide regulated|nsubjpass|expression expression|compound|END_ENTITY	GTP_cyclohydrolase_I expression is regulated by nitric_oxide : role of cyclic_AMP .
8304105	0	cyclic_AMP	101,111	GTP_cyclohydrolase_I	122,142	cyclic AMP	GTP cyclohydrolase I	MESH:D000242	2643	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Regulation of tetrahydrobiopterin biosynthesis in cultured hypothalamic and mesencephalic neurons by cyclic_AMP dependent GTP_cyclohydrolase_I gene expression .
11145992	0	cyclic_AMP	51,61	Galanin_receptor_1	0,18	cyclic AMP	Galanin receptor 1	MESH:D000242	14427(Tax:10090)	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	Galanin_receptor_1 gene expression is regulated by cyclic_AMP through a CREB-dependent mechanism .
8702397	0	cyclic_AMP	88,98	Glucose-dependent_insulinotropic_polypeptide	0,44	cyclic AMP	Glucose-dependent insulinotropic polypeptide	MESH:D000242	2695	Chemical	Gene	secretion|nmod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Glucose-dependent_insulinotropic_polypeptide stimulates insulin secretion via increased cyclic_AMP and -LSB- Ca2 + -RSB- 1 and a wortmannin-sensitive signalling pathway .
7532776	0	cyclic_AMP	43,53	Growth_hormone	0,14	cyclic AMP	Growth hormone	MESH:D000242	81668(Tax:10116)	Chemical	Gene	secretion|nmod|START_ENTITY END_ENTITY|dobj|secretion	Growth_hormone secretion and activation of cyclic_AMP by growth_hormone_releasing_hormone and gamma-aminobutyric_acid in the neonatal rat pituitary .
10449982	0	cyclic_AMP	42,52	IGF-I	73,78	cyclic AMP	IGF-I	MESH:D000242	16000(Tax:10090)	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	Serotonin receptor agonists that increase cyclic_AMP positively regulate IGF-I in mouse mandibular mesenchymal cells .
15115662	0	cyclic_AMP	41,51	IL-1beta	55,63	cyclic AMP	IL-1beta	MESH:D000242	3553	Chemical	Gene	effects|nmod|START_ENTITY involved|nmod|effects involved|nmod|END_ENTITY	JNK signaling involved in the effects of cyclic_AMP on IL-1beta plus IFNgamma-induced inducible nitric_oxide synthase expression in hepatocytes .
2553585	0	cyclic_AMP	231,241	IL-5	116,120	cyclic AMP	IL-5	MESH:D000242	16191(Tax:10090)	Chemical	Gene	levels|compound|START_ENTITY END_ENTITY|nmod|levels	Different effect of prostaglandin_E2 on B-cell activation by two distinct B-cell differentiation factors , B151-TRF1 / IL-5 and B151-TRF2 : selective inhibition of B151-TRF2-induced antibody response through increases in intracellular cyclic_AMP levels .
2478121	0	cyclic_AMP	103,113	Insulin	0,7	cyclic AMP	Insulin	MESH:D000242	3630	Chemical	Gene	phosphodiesterase|compound|START_ENTITY phosphorylation|nmod|phosphodiesterase stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Insulin stimulates the tyrosyl phosphorylation and activation of the 52 kDa peripheral plasma-membrane cyclic_AMP phosphodiesterase in intact hepatocytes .
6311178	0	cyclic_AMP	76,86	Insulin	0,7	cyclic AMP	Insulin	MESH:D000242	3630	Chemical	Gene	phosphodiesterases|compound|START_ENTITY activation|nmod|phosphodiesterases regulate|dobj|activation regulate|nsubj|END_ENTITY	Insulin and glucagon regulate the activation of two distinct membrane-bound cyclic_AMP phosphodiesterases in hepatocytes .
6316937	0	cyclic_AMP	56,66	Insulin	0,7	cyclic AMP	Insulin	MESH:D000242	3630	Chemical	Gene	phosphodiesterase|compound|START_ENTITY activates|dobj|phosphodiesterase activates|nsubj|END_ENTITY	Insulin activates the plasma-membrane and dense-vesicle cyclic_AMP phosphodiesterase in hepatocytes by distinct routes .
7578979	0	cyclic_AMP	58,68	Interleukin_1	0,13	cyclic AMP	Interleukin 1	MESH:D000242	3552	Chemical	Gene	production|compound|START_ENTITY induces|nmod|production induces|nsubj|END_ENTITY	Interleukin_1 induces prostacyclin-dependent increases in cyclic_AMP production and does not affect cyclic_GMP production in human vascular smooth muscle cells .
181189	0	cyclic_AMP	15,25	LIF	58,61	cyclic AMP	LIF	MESH:D000242	3976	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|production production|appos|END_ENTITY	The effects of cyclic_AMP on leucocyte_inhibitory_factor -LRB- LIF -RRB- production and on the inhibition of leucocyte migration .
25190474	0	cyclic_AMP	33,43	MRP2	79,83	cyclic AMP	MRP2	MESH:D000242	1244	Chemical	Gene	translocation|amod|START_ENTITY translocation|compound|END_ENTITY	Rab11 , but not Rab4 , facilitates cyclic_AMP - and tauroursodeoxycholate-induced MRP2 translocation to the plasma membrane .
9514100	0	cyclic_AMP	9,19	MT1-MMP	44,51	cyclic AMP	MT1-MMP	MESH:D000242	4323	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Elevated cyclic_AMP suppresses ConA-induced MT1-MMP expression in MDA-MB-231 human breast_cancer cells .
20624391	0	cyclic_AMP	13,23	NF-kappaB	52,61	cyclic AMP	NF-kappaB	MESH:D000242	4790	Chemical	Gene	Elevation|nmod|START_ENTITY causes|nsubj|Elevation causes|dobj|imbalance imbalance|nmod|END_ENTITY	Elevation of cyclic_AMP causes an imbalance between NF-kappaB and p53 in NALM-6 cells treated by doxorubicin .
9878303	0	cyclic_AMP	119,129	NF-kappaB	82,91	cyclic AMP	NF-kappaB	MESH:D000242	18033(Tax:10090)	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Release of tumor_necrosis_factor-alpha from coronary smooth muscle : activation of NF-kappaB and inhibition by elevated cyclic_AMP .
10593859	0	cyclic_AMP	81,91	NOS2	72,76	cyclic AMP	NOS2	MESH:D000242	4843	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of the expression of the inflammatory nitric_oxide_synthase -LRB- NOS2 -RRB- by cyclic_AMP .
2985756	0	cyclic_AMP	28,38	Nerve_growth_factor	0,19	cyclic AMP	Nerve growth factor	MESH:D000242	4803	Chemical	Gene	metabolism|compound|START_ENTITY affects|dobj|metabolism affects|nsubj|END_ENTITY	Nerve_growth_factor affects cyclic_AMP metabolism , but not by directly stimulating adenylate cyclase activity .
6315882	0	cyclic_AMP	106,116	Nerve_growth_factor	0,19	cyclic AMP	Nerve growth factor	MESH:D000242	396466(Tax:9031)	Chemical	Gene	target|nmod|START_ENTITY phospholipid|nmod|target phospholipid|nsubj|stimulates stimulates|compound|END_ENTITY	Nerve_growth_factor stimulates phospholipid methylation in target ganglionic neurons independently of the cyclic_AMP and sodium pump responses .
1359017	0	cyclic_AMP	91,101	Neuropeptide_Y	0,14	cyclic AMP	Neuropeptide Y	MESH:D000242	24604(Tax:10116)	Chemical	Gene	accumulation|compound|START_ENTITY inhibits|dobj|accumulation inhibits|nsubj|END_ENTITY	Neuropeptide_Y inhibits beta-adrenergic agonist - and vasoactive intestinal peptide-induced cyclic_AMP accumulation in rat pinealocytes through pertussis toxin-sensitive G protein .
15063152	0	cyclic_AMP	24,34	P450scc	69,76	cyclic AMP	P450scc	MESH:D000242	29680(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Effects of S-petasin on cyclic_AMP production and enzyme activity of P450scc in rat zona_fasciculata-reticularis cells .
1700277	0	cyclic_AMP	47,57	P450scc	6,13	cyclic AMP	P450scc	MESH:D000242	1583	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|transcription transcription|compound|END_ENTITY	Human P450scc gene transcription is induced by cyclic_AMP and repressed by 12-O-tetradecanoylphorbol-13-acetate and A23187 through independent cis elements .
10389149	0	cyclic_AMP	84,94	PACAP	74,79	cyclic AMP	PACAP	MESH:D000242	24166(Tax:10116)	Chemical	Gene	formation|compound|START_ENTITY effect|nmod|formation effect|appos|END_ENTITY	Stimulatory effect of pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- on cyclic_AMP formation in the hypothalamus and cerebral cortex of four avians and rat .
10909177	0	cyclic_AMP	73,83	PACAP	63,68	cyclic AMP	PACAP	MESH:D000242	101800734	Chemical	Gene	formation|compound|START_ENTITY Effects|nmod|formation Effects|appos|END_ENTITY	Effects of pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- on cyclic_AMP formation in the duck and goose brain .
11785909	0	cyclic_AMP	42,52	PACAP	129,134	cyclic AMP	PACAP	MESH:D000242	408251(Tax:9031)	Chemical	Gene	formation|compound|START_ENTITY dexamethasone|nmod|formation Effect|nmod|dexamethasone stimulated|nsubj|Effect stimulated|nmod|pituitary_adenylate_cyclase-activating_polypeptide pituitary_adenylate_cyclase-activating_polypeptide|appos|END_ENTITY	Effect of glucocorticoid dexamethasone on cyclic_AMP formation stimulated by pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- in the cerebral cortex and hypothalamus of chick .
1280235	0	cyclic_AMP	59,69	PACAP	41,46	cyclic AMP	PACAP	MESH:D000242	116	Chemical	Gene	formation|compound|START_ENTITY stimulates|dobj|formation stimulates|nsubj|polypeptide polypeptide|appos|END_ENTITY	Pituitary adenylate cyclase polypeptide -LRB- PACAP -RRB- stimulates cyclic_AMP formation in pituitary fibroblasts and 3T3 tumor fibroblasts : lack of enhancement by protein_kinase_C activation .
12926554	0	cyclic_AMP	78,88	PACAP	52,57	cyclic AMP	PACAP	MESH:D000242	408251(Tax:9031)	Chemical	Gene	production|compound|START_ENTITY increase|nmod|production polypeptide|dep|increase polypeptide|appos|END_ENTITY	Pituitary adenylate cyclase-activating polypeptide -LRB- PACAP -RRB- - evoked increase in cyclic_AMP production in chick cerebral cortex : lack of a role of the protein_kinase_C pathway .
1315448	0	cyclic_AMP	70,80	PACAP	52,57	cyclic AMP	PACAP	MESH:D000242	116	Chemical	Gene	formation|compound|START_ENTITY stimulates|dobj|formation stimulates|nsubj|Pituitary_adenylate_cyclase-activating_polypeptide Pituitary_adenylate_cyclase-activating_polypeptide|appos|END_ENTITY	Pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- stimulates cyclic_AMP formation as well as peptide output of cultured pituitary melanotrophs and AtT-20 corticotrophs .
17521773	0	cyclic_AMP	28,38	PACAP	11,16	cyclic AMP	PACAP	MESH:D000242	24166(Tax:10116)	Chemical	Gene	formation|compound|START_ENTITY Effects|nmod|formation Effects|nmod|END_ENTITY	Effects of PACAP and VIP on cyclic_AMP formation in rat neuronal and astrocyte cultures under normoxic and hypoxic_condition .
17901570	0	cyclic_AMP	46,56	PACAP	11,16	cyclic AMP	PACAP	MESH:D000242	24166(Tax:10116)	Chemical	Gene	formation|compound|START_ENTITY Effects|nmod|formation Effects|nmod|END_ENTITY	Effects of PACAP , VIP and related peptides on cyclic_AMP formation in rat neuronal and astrocyte cultures and cerebral cortical slices .
19346254	0	cyclic_AMP	88,98	PACAP	81,86	cyclic AMP	PACAP	MESH:D000242	24166(Tax:10116)	Chemical	Gene	pathway|compound|START_ENTITY pathway|dep|element element|nmod|pituitary_adenylate_cyclase-activating_polypeptide pituitary_adenylate_cyclase-activating_polypeptide|appos|END_ENTITY	Lot1 is a key element of the pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- / cyclic_AMP pathway that negatively regulates neuronal precursor proliferation .
25712659	0	cyclic_AMP	4,14	PACAP	57,62	cyclic AMP	PACAP	MESH:D000242	24166(Tax:10116)	Chemical	Gene	effects|compound|START_ENTITY effects|nmod|END_ENTITY	The cyclic_AMP effects and neuroprotective activities of PACAP and VIP in cultured astrocytes and neurons exposed to oxygen-glucose_deprivation .
7589782	0	cyclic_AMP	110,120	PACAP	81,86	cyclic AMP	PACAP	MESH:D000242	24166(Tax:10116)	Chemical	Gene	production|nmod|START_ENTITY regulation|dep|production regulation|nmod|pituitary_adenylate_cyclase-activating_polypeptide pituitary_adenylate_cyclase-activating_polypeptide|appos|END_ENTITY	Multifactorial regulation of pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- - induced production of cyclic_AMP in ATT-20 corticotrophs : major involvement of Rolipram-sensitive and insensitive phosphodiesterases .
8391488	0	cyclic_AMP	148,158	PACAP	126,131	cyclic AMP	PACAP	MESH:D000242	24166(Tax:10116)	Chemical	Gene	formation|compound|START_ENTITY stimulating|dobj|formation interact|advcl|stimulating interact|nmod|polypeptide polypeptide|appos|END_ENTITY	Vasopressin , unlike phorbol_ester , fails to synergistically interact with pituitary adenylate cyclase activating polypeptide -LRB- PACAP -RRB- in stimulating cyclic_AMP formation and ACTH secretion in cultured anterior pituitary cells .
7575434	0	cyclic_AMP	126,136	PDE4A	120,125	cyclic AMP	PDE4A	MESH:D000242	5141	Chemical	Gene	family|compound|START_ENTITY family|compound|END_ENTITY	Identification , characterization and regional distribution in brain of RPDE-6 -LRB- RNPDE4A5 -RRB- , a novel splice variant of the PDE4A cyclic_AMP phosphodiesterase family .
6307295	0	cyclic_AMP	91,101	PGD2	114,118	cyclic AMP	PGD2	MESH:D000242	5730	Chemical	Gene	production|compound|START_ENTITY production|appos|END_ENTITY	The cytoplasmic concentration of free calcium in platelets is controlled by stimulators of cyclic_AMP production -LRB- PGD2 , PGE1 , forskolin -RRB- .
177292	6	cyclic_AMP	659,669	PTH	612,615	cyclic AMP	PTH	MESH:D000242	5741	Chemical	Gene	excretion|nmod|START_ENTITY increase|dobj|excretion increase|nsubj|levels levels|compound|END_ENTITY	During vitamin_D deficiency , high PTH levels can increase the renal excretion of cyclic_AMP .
1851004	0	cyclic_AMP	56,66	PTH	96,99	cyclic AMP	PTH	MESH:D000242	24694(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY desensitization|nmod|production induces|dobj|desensitization induces|advcl|decreasing decreasing|xcomp|binding binding|nsubj|receptor receptor|compound|END_ENTITY	Phorbol_ester induces desensitization of PTH-stimulated cyclic_AMP production by decreasing the PTH receptor binding in UMR-106 cells .
25431134	0	cyclic_AMP	77,87	PTH	24,27	cyclic AMP	PTH	MESH:D000242	5741	Chemical	Gene	junctions|compound|START_ENTITY accumulation|nmod|junctions Sustained|nsubj|accumulation Sustained|xcomp|signalling signalling|nmod|END_ENTITY	Sustained signalling by PTH modulates IP3 accumulation and IP3 receptors via cyclic_AMP junctions .
2987641	0	cyclic_AMP	3,13	PTH	47,50	cyclic AMP	PTH	MESH:D000242	5741	Chemical	Gene	concentrations|compound|START_ENTITY reflect|nsubj|concentrations reflect|dobj|activity activity|compound|END_ENTITY	Do cyclic_AMP concentrations in saliva reflect PTH biologic activity ?
6262082	0	cyclic_AMP	208,218	PTH	241,244	cyclic AMP	PTH	MESH:D000242	5741	Chemical	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	Secondary_hyperparathyroidism with 1,25-dihydroxyvitamin _ D deficiency and pseudohypoparathyroidism in childhood : relationship between plasma 1,25-dihydroxyvitamin _ D and parathyroid_hormone levels and urinary cyclic_AMP response to exogenous PTH .
2546638	0	cyclic_AMP	54,64	PTH-related_peptide	17,36	cyclic AMP	PTH-related peptide	MESH:D000242	5744	Chemical	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	Effects of human PTH-related_peptide and human PTH on cyclic_AMP production and cytosolic free calcium in an osteoblastic cell clone .
10915220	0	cyclic_AMP	91,101	Parathyroid_hormone	0,19	cyclic AMP	Parathyroid hormone	MESH:D000242	24694(Tax:10116)	Chemical	Gene	element-binding|compound|START_ENTITY facilitated|nmod|element-binding Ets-1|acl|facilitated rat|nmod|Ets-1 induces|xcomp|rat induces|nsubj|END_ENTITY	Parathyroid_hormone induces rat interstitial collagenase mRNA through Ets-1 facilitated by cyclic_AMP response element-binding protein and Ca -LRB- 2 + -RRB- / calmodulin-dependent protein kinase II in osteoblastic cells .
12522076	0	cyclic_AMP	120,130	Parathyroid_hormone	0,19	cyclic AMP	Parathyroid hormone	MESH:D000242	5741	Chemical	Gene	independent|nmod|START_ENTITY mechanism|acl:relcl|independent increases|nmod|mechanism increases|nsubj|END_ENTITY	Parathyroid_hormone increases the sensitivity of inositol_trisphosphate receptors by a mechanism that is independent of cyclic_AMP .
19180574	0	cyclic_AMP	76,86	Parathyroid_hormone	0,19	cyclic AMP	Parathyroid hormone	MESH:D000242	5741	Chemical	Gene	element|compound|START_ENTITY activate|dobj|element pathways|xcomp|activate pathways|nsubj|synergizes synergizes|amod|END_ENTITY	Parathyroid_hormone synergizes with non-cyclic_AMP pathways to activate the cyclic_AMP response element .
2426285	0	cyclic_AMP	129,139	Parathyroid_hormone	0,19	cyclic AMP	Parathyroid hormone	MESH:D000242	19226(Tax:10090)	Chemical	Gene	involvement|nmod|START_ENTITY stimulation|dep|involvement stimulation|amod|END_ENTITY	Parathyroid_hormone stimulation of alkaline phosphatase activity in cultured neonatal mouse calvarial bone cells : involvement of cyclic_AMP and calcium .
2844065	0	cyclic_AMP	87,97	Parathyroid_hormone	0,19	cyclic AMP	Parathyroid hormone	MESH:D000242	24694(Tax:10116)	Chemical	Gene	independent|nmod|START_ENTITY independent|nsubj|stimulation stimulation|amod|END_ENTITY	Parathyroid_hormone stimulation of mitosis in rat thymic lymphocytes is independent of cyclic_AMP .
2852449	0	cyclic_AMP	61,71	Parathyroid_hormone	0,19	cyclic AMP	Parathyroid hormone	MESH:D000242	5741	Chemical	Gene	enhancement|nmod|START_ENTITY enhancement|amod|END_ENTITY	Parathyroid_hormone and noradrenaline-induced enhancement of cyclic_AMP in a cloned osteogenic_sarcoma cell line -LRB- UMR 106 -RRB- is inhibited by neuropeptide Y.
6253291	0	cyclic_AMP	51,61	Parathyroid_hormone	0,19	cyclic AMP	Parathyroid hormone	MESH:D000242	403986(Tax:9615)	Chemical	Gene	excretion|compound|START_ENTITY increase|dobj|excretion increase|nsubj|END_ENTITY	Parathyroid_hormone does not increase nephrogenous cyclic_AMP excretion by the dog .
9705077	0	cyclic_AMP	33,43	Parathyroid_hormone	0,19	cyclic AMP	Parathyroid hormone	MESH:D000242	24694(Tax:10116)	Chemical	Gene	responses|nmod|START_ENTITY END_ENTITY|dobj|responses	Parathyroid_hormone responses of cyclic_AMP - , serum - and phorbol_ester-responsive reporter genes in osteoblast-like UMR-106 cells .
9651115	0	cyclic_AMP	88,98	Parathyroid_hormone-related_protein	0,35	cyclic AMP	Parathyroid hormone-related protein	MESH:D000242	5744	Chemical	Gene	increases|nmod|START_ENTITY increases|nsubj|END_ENTITY	Parathyroid_hormone-related_protein increases DNA synthesis in proximal tubule cells by cyclic_AMP - and protein_kinase_C-dependent pathways .
19564421	0	cyclic_AMP	43,53	Phox2a	29,35	cyclic AMP	Phox2a	MESH:D000242	401	Chemical	Gene	pathway|compound|START_ENTITY END_ENTITY|nmod|pathway	Time-dependent activation of Phox2a by the cyclic_AMP pathway modulates onset and duration of p27Kip1 transcription .
8708540	0	cyclic_AMP	58,68	Pituitary_adenylate_cyclase-activating_peptide	0,46	cyclic AMP	Pituitary adenylate cyclase-activating peptide	MESH:D000242	24166(Tax:10116)	Chemical	Gene	accumulation|compound|START_ENTITY accumulation|amod|END_ENTITY	Pituitary_adenylate_cyclase-activating_peptide stimulates cyclic_AMP accumulation in UMR 106 osteoblast-like cells .
1315448	0	cyclic_AMP	70,80	Pituitary_adenylate_cyclase-activating_polypeptide	0,50	cyclic AMP	Pituitary adenylate cyclase-activating polypeptide	MESH:D000242	116	Chemical	Gene	formation|compound|START_ENTITY stimulates|dobj|formation stimulates|nsubj|END_ENTITY	Pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- stimulates cyclic_AMP formation as well as peptide output of cultured pituitary melanotrophs and AtT-20 corticotrophs .
15899261	0	cyclic_AMP	49,59	Pleiotrophin	0,12	cyclic AMP	Pleiotrophin	MESH:D000242	5764	Chemical	Gene	effect|nmod|START_ENTITY mediates|dobj|effect mediates|nsubj|END_ENTITY	Pleiotrophin mediates the neurotrophic effect of cyclic_AMP on dopaminergic neurons : analysis of suppression-subtracted cDNA libraries and confirmation in vitro .
6292372	0	cyclic_AMP	11,21	S-100	25,30	cyclic AMP	S-100	MESH:D000242	6285	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|level level|compound|END_ENTITY	Effects of cyclic_AMP on S-100 protein level in C-6 glioma cells .
23559126	8	cyclic_AMP	1284,1294	SCF	1316,1319	cyclic AMP	SCF	MESH:D000242	17311(Tax:10090)	Chemical	Gene	levels|compound|START_ENTITY levels|acl|stimulated stimulated|nmod|END_ENTITY	An additional inhibitory function of glyceollins was to effectively downregulate intracellular cyclic_AMP levels stimulated by SCF in B16F10 cells .
2437575	0	cyclic_AMP	20,30	Secretin	0,8	cyclic AMP	Secretin	MESH:D000242	24769(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Secretin stimulates cyclic_AMP and inositol_trisphosphate production in rat pancreatic acinar tissue by two fully independent mechanisms .
3009718	0	cyclic_AMP	20,30	Secretin	0,8	cyclic AMP	Secretin	MESH:D000242	24769(Tax:10116)	Chemical	Gene	formation|compound|START_ENTITY stimulates|dobj|formation stimulates|nsubj|END_ENTITY	Secretin stimulates cyclic_AMP formation in the rat brain .
12456005	0	cyclic_AMP	21,31	Sgt1p	0,5	cyclic AMP	Sgt1p	MESH:D000242	854222(Tax:4932)	Chemical	Gene	contributes|xcomp|START_ENTITY contributes|nsubj|END_ENTITY	Sgt1p contributes to cyclic_AMP pathway activity and physically interacts with the adenylyl cyclase Cyr1p/Cdc35p in budding yeast .
224550	0	cyclic_AMP	38,48	Somatostatin	0,12	cyclic AMP	Somatostatin	MESH:D000242	6750	Chemical	Gene	inhibition|nmod|START_ENTITY END_ENTITY|dep|inhibition	Somatostatin : selective inhibition of cyclic_AMP stimulated protein kinase .
7513037	0	cyclic_AMP	42,52	Substance_P	0,11	cyclic AMP	Substance P	MESH:D000242	6863	Chemical	Gene	production|compound|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	Substance_P enhances forskolin-stimulated cyclic_AMP production in human UC11MG astrocytoma cells .
21612641	0	cyclic_AMP	95,105	TGF-b1	12,18	cyclic AMP	TGF-b1	MESH:D000242	7040	Chemical	Gene	stimulation|nmod|START_ENTITY stimulation|compound|END_ENTITY	Reversal of TGF-b1 stimulation of a-smooth muscle actin and extracellular matrix components by cyclic_AMP in Dupuytren 's - derived fibroblasts .
83946	0	cyclic_AMP	30,40	TRH	10,13	cyclic AMP	TRH	MESH:D000242	7200	Chemical	Gene	levels|compound|START_ENTITY Effect|nmod|levels Effect|nmod|END_ENTITY	Effect of TRH and dopamine on cyclic_AMP levels in enriched mammotroph and thyrotroph cells .
17392505	0	cyclic_AMP	33,43	Thrombin	0,8	cyclic AMP	Thrombin	MESH:D000242	2147	Chemical	Gene	concentration|compound|START_ENTITY regulates|dobj|concentration regulates|nsubj|END_ENTITY	Thrombin regulates intracellular cyclic_AMP concentration in human platelets through phosphorylation/activation of phosphodiesterase 3A .
196696	0	cyclic_AMP	28,38	Thrombin	0,8	cyclic AMP	Thrombin	MESH:D000242	2147	Chemical	Gene	decreases|dobj|START_ENTITY decreases|nsubj|END_ENTITY	Thrombin decreases platelet cyclic_AMP in the absence of prostaglandin synthesis .
1324244	0	cyclic_AMP	60,70	Transforming_growth_factor-beta	0,31	cyclic AMP	Transforming growth factor-beta	MESH:D000242	7040	Chemical	Gene	production|compound|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	Transforming_growth_factor-beta enhances calcitonin-induced cyclic_AMP production and the number of calcitonin_receptors in long-term cultures of human umbilical cord blood monocytes in the presence of 1,25-dihydroxycholecalciferol .
1310016	0	cyclic_AMP	106,116	Tumor_necrosis_factor_alpha	0,27	cyclic AMP	Tumor necrosis factor alpha	MESH:D000242	7124	Chemical	Gene	formation|compound|START_ENTITY parathyroid_hormone-related_protein|nmod|formation effect|nmod|parathyroid_hormone-related_protein inhibits|dobj|effect inhibits|nsubj|END_ENTITY	Tumor_necrosis_factor_alpha inhibits the stimulatory effect of the parathyroid_hormone-related_protein on cyclic_AMP formation in osteoblast-like cells via protein kinase C + .
6089132	0	cyclic_AMP	22,32	VIP	15,18	cyclic AMP	VIP	MESH:D000242	100352512(Tax:9986)	Chemical	Gene	levels|compound|START_ENTITY effects|nmod|levels effects|nmod|END_ENTITY	The effects of VIP on cyclic_AMP and glycogen levels in vertebrate retina .
6112141	0	cyclic_AMP	49,59	Vasoactive_intestinal_polypeptide	0,33	cyclic AMP	Vasoactive intestinal polypeptide	MESH:D000242	117064(Tax:10116)	Chemical	Gene	formation|compound|START_ENTITY stimulation|nmod|formation stimulation|amod|END_ENTITY	Vasoactive_intestinal_polypeptide stimulation of cyclic_AMP formation in rat central nervous system .
7535423	0	cyclic_AMP	45,55	Vasoactive_intestinal_polypeptide	0,33	cyclic AMP	Vasoactive intestinal polypeptide	MESH:D000242	22353(Tax:10090)	Chemical	Gene	production|compound|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Vasoactive_intestinal_polypeptide stimulates cyclic_AMP production in mouse N1E-115 neuroblastoma cells : modulation by a protein kinase C activator and ionomycin .
10586949	0	cyclic_AMP	29,39	adrenomedullin	11,25	cyclic AMP	adrenomedullin	MESH:D000242	133	Chemical	Gene	formation|compound|START_ENTITY END_ENTITY|nmod|formation	Effects of adrenomedullin on cyclic_AMP formation and on relaxation in iris sphincter smooth muscle .
13410	0	cyclic_AMP	49,59	alpha-MSH	18,27	cyclic AMP	alpha-MSH	MESH:D000242	24664(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY Investigations|nmod|levels Investigations|nmod|effects effects|compound|END_ENTITY	Investigations on alpha-MSH and MIF-1 effects on cyclic_AMP levels in rat brain .
7716065	0	cyclic_AMP	18,28	alpha-MSH	0,9	cyclic AMP	alpha-MSH	MESH:D000242	24664(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|changes changes|amod|END_ENTITY	alpha-MSH changes cyclic_AMP levels in rat brain slices by an interaction with the D1 dopamine receptor .
8382813	0	cyclic_AMP	66,76	alpha-MSH	40,49	cyclic AMP	alpha-MSH	MESH:D000242	24664(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY effects|nmod|levels effects|nmod|END_ENTITY	Independent and simultaneous effects of alpha-MSH and dopamine on cyclic_AMP levels in rat brain slices .
8390199	0	cyclic_AMP	66,76	alpha-MSH	40,49	cyclic AMP	alpha-MSH	MESH:D000242	24664(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY effects|nmod|levels effects|nmod|END_ENTITY	Independent and simultaneous effects of alpha-MSH and dopamine on cyclic_AMP levels in rat brain slices .
8971923	0	cyclic_AMP	25,35	alpha-MSH	10,19	cyclic AMP	alpha-MSH	MESH:D000242	5443	Chemical	Gene	levels|compound|START_ENTITY END_ENTITY|nmod|levels	Effect of alpha-MSH upon cyclic_AMP levels induced by the glutamatergic agonists NMDA , quisqualic_acid , and kainic_acid .
3020142	0	cyclic_AMP	55,65	alpha-melanocyte-stimulating_hormone	11,47	cyclic AMP	alpha-melanocyte-stimulating hormone	MESH:D000242	24664(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY Effects|nmod|metabolism Effects|nmod|END_ENTITY	Effects of alpha-melanocyte-stimulating_hormone on the cyclic_AMP and phospholipid metabolism of rat adrenocortical cells .
3025536	0	cyclic_AMP	110,120	angiotensin_I	21,34	cyclic AMP	angiotensin I	MESH:D000242	183	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Enhancing effects of angiotensin_I on the vasopressin-stimulated water flow of toad bladder through increased cyclic_AMP in mucosal cells .
189568	0	cyclic_AMP	63,73	angiotensin_II	22,36	cyclic AMP	angiotensin II	MESH:D000242	183	Chemical	Gene	role|nmod|START_ENTITY effect|dep|role effect|nmod|END_ENTITY	Hydrosmotic effect of angiotensin_II in the toad skin : role of cyclic_AMP .
204314	0	cyclic_AMP	8,18	angiotensin_II	71,85	cyclic AMP	angiotensin II	MESH:D000242	183	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of cyclic_AMP and angiotensin_III in the response of toad skin to angiotensin_II .
8955337	0	cyclic_AMP	61,71	apolipoprotein_E	30,46	cyclic AMP	apolipoprotein E	MESH:D000242	348	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Transcriptional regulation of apolipoprotein_E expression by cyclic_AMP .
8060479	0	cyclic_AMP	86,96	atrial_natriuretic_peptide	18,44	cyclic AMP	atrial natriuretic peptide	MESH:D000242	24602(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY Lack|nmod|production Lack|nmod|END_ENTITY	Lack of effect of atrial_natriuretic_peptide and urodilatin on vasopressin-stimulated cyclic_AMP production in microdissected rat inner medullary collecting ducts .
14517215	0	cyclic_AMP	106,116	bradykinin	30,40	cyclic AMP	bradykinin	MESH:D000242	3827	Chemical	Gene	element|compound|START_ENTITY mediated|nmod|element mediated|nsubjpass|induction induction|nmod|END_ENTITY	Cyclooxygenase-2 induction by bradykinin in human pulmonary artery smooth muscle cells is mediated by the cyclic_AMP response element through a novel autocrine loop involving endogenous prostaglandin_E2 , E-prostanoid_2 -LRB- EP2 -RRB- , and EP4 receptors .
7921603	0	cyclic_AMP	14,24	bradykinin	45,55	cyclic AMP	bradykinin	MESH:D000242	3827	Chemical	Gene	agents|compound|START_ENTITY agents|nmod|transduction transduction|amod|END_ENTITY	The effect of cyclic_AMP elevating agents on bradykinin - and carbachol-induced signal transduction in canine cultured tracheal smooth muscle cells .
18172855	0	cyclic_AMP	59,69	c-fos	30,35	cyclic AMP	c-fos	MESH:D000242	314322(Tax:10116)	Chemical	Gene	protein|compound|START_ENTITY involves|dobj|protein involves|nsubj|up-regulation up-regulation|amod|END_ENTITY	Lysophosphatidic_acid-induced c-fos up-regulation involves cyclic_AMP response element-binding protein activated by mitogen - _ and_stress-activated_protein_kinase-1 .
1851095	0	cyclic_AMP	73,83	c-fos	28,33	cyclic AMP	c-fos	MESH:D000242	2353	Chemical	Gene	transcription|nmod|START_ENTITY transcription|amod|END_ENTITY	Differences in induction of c-fos transcription by cholera toxin-derived cyclic_AMP and Ca2 + signals in astrocytes and 3T3 fibroblasts .
2127926	0	cyclic_AMP	92,102	c-fos	33,38	cyclic AMP	c-fos	MESH:D000242	2353	Chemical	Gene	induction|nmod|START_ENTITY detection|dep|induction detection|nmod|proteins proteins|amod|END_ENTITY	Immunohistochemical detection of c-fos proteins in cultured human glial cells -- induction by cyclic_AMP and phorbol_ester .
2170155	0	cyclic_AMP	115,125	c-fos	24,29	cyclic AMP	c-fos	MESH:D000242	14281(Tax:10090)	Chemical	Gene	accumulation|compound|START_ENTITY role|nmod|accumulation stimulation|dep|role stimulation|nmod|expression expression|amod|END_ENTITY	Bombesin stimulation of c-fos expression and mitogenesis in Swiss_3T3 cells : the role of prostaglandin_E2-mediated cyclic_AMP accumulation .
2555687	0	cyclic_AMP	73,83	c-fos	112,117	cyclic AMP	c-fos	MESH:D000242	14281(Tax:10090)	Chemical	Gene	responsiveness|compound|START_ENTITY responsiveness|nmod|promoter promoter|compound|END_ENTITY	Multiple sequence elements of a single functional class are required for cyclic_AMP responsiveness of the mouse c-fos promoter .
7476883	0	cyclic_AMP	19,29	c-fos	80,85	cyclic AMP	c-fos	MESH:D000242	14281(Tax:10090)	Chemical	Gene	response|compound|START_ENTITY Phosphorylation|nmod|response element-binding|nsubj|Phosphorylation element-binding|dobj|protein protein|nmod|expression expression|amod|END_ENTITY	Phosphorylation of cyclic_AMP response element-binding protein and induction of c-fos gene expression on withdrawal from chronic treatment with carbachol in NG108-15 cells .
7798940	0	cyclic_AMP	70,80	c-fos	33,38	cyclic AMP	c-fos	MESH:D000242	2353	Chemical	Gene	transcription|nmod|START_ENTITY elements|amod|transcription END_ENTITY|dobj|elements	Beta_2-adrenoreceptors stimulate c-fos transcription through multiple cyclic_AMP - and Ca -LRB- 2 + -RRB- - responsive elements in cerebellar granular neurons .
8709975	0	cyclic_AMP	56,66	c-fos	14,19	cyclic AMP	c-fos	MESH:D000242	314322(Tax:10116)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of c-fos mRNA expression in Sertoli cells by cyclic_AMP , calcium , and protein_kinase_C mediated pathways .
9187264	0	cyclic_AMP	52,62	c-fos	38,43	cyclic AMP	c-fos	MESH:D000242	2353	Chemical	Gene	production|compound|START_ENTITY modulates|nmod|production modulates|dobj|expression expression|nmod|END_ENTITY	Histamine modulates the expression of c-fos through cyclic_AMP production via the H2 receptor in the human promonocytic cell line U937 .
18456811	0	cyclic_AMP	88,98	cAMP_receptor_protein	125,146	cyclic AMP	cAMP receptor protein	MESH:D000242	20468888	Chemical	Gene	specificity|amod|START_ENTITY specificity|nmod|END_ENTITY	Two-state allosteric modeling suggests protein equilibrium as an integral component for cyclic_AMP -LRB- cAMP -RRB- specificity in the cAMP_receptor_protein of Escherichia_coli .
1646609	0	cyclic_AMP	17,27	calcitonin_gene-related_peptide	61,92	cyclic AMP	calcitonin gene-related peptide	MESH:D000242	24241(Tax:10116)	Chemical	Gene	formation|compound|START_ENTITY increases|dobj|formation increases|nmod|receptors receptors|amod|END_ENTITY	Amylin increases cyclic_AMP formation in L6 myocytes through calcitonin_gene-related_peptide receptors .
2543186	0	cyclic_AMP	46,56	calcitonin_gene-related_peptide	11,42	cyclic AMP	calcitonin gene-related peptide	MESH:D000242	12310(Tax:10090)	Chemical	Gene	formation|compound|START_ENTITY END_ENTITY|nmod|formation	Effects of calcitonin_gene-related_peptide on cyclic_AMP formation in chicken , rat , and mouse bone cells .
2844436	0	cyclic_AMP	73,83	calcitonin_gene-related_peptide	29,60	cyclic AMP	calcitonin gene-related peptide	MESH:D000242	24241(Tax:10116)	Chemical	Gene	mediated|nmod|START_ENTITY mediated|nsubj|effect effect|nmod|END_ENTITY	Positive inotropic effect of calcitonin_gene-related_peptide mediated by cyclic_AMP in guinea_pig heart .
3029484	0	cyclic_AMP	49,59	calcitonin_gene-related_peptide	10,41	cyclic AMP	calcitonin gene-related peptide	MESH:D000242	12310(Tax:10090)	Chemical	Gene	level|compound|START_ENTITY Effect|nmod|level Effect|nmod|END_ENTITY	Effect of calcitonin_gene-related_peptide on the cyclic_AMP level of isolated mouse diaphragm .
7513384	0	cyclic_AMP	71,81	calcitonin_gene-related_peptide	128,159	cyclic AMP	calcitonin gene-related peptide	MESH:D000242	24241(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY vasodilations|nmod|levels inhibits|dobj|vasodilations inhibits|nmod|aorta aorta|acl|induced induced|nmod|END_ENTITY	N_omega-nitro-L-arginine inhibits vasodilations and elevations of both cyclic_AMP and cyclic_GMP levels in rat aorta induced by calcitonin_gene-related_peptide -LRB- CGRP -RRB- .
9789841	0	cyclic_AMP	34,44	choline_acetyltransferase	66,91	cyclic AMP	choline acetyltransferase	MESH:D000242	12647(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Influence of retinoic_acid and of cyclic_AMP on the expression of choline_acetyltransferase and of vesicular acetylcholine transporter in NG108-15 cells .
6285350	0	cyclic_AMP	15,25	corticotropin-releasing_factor	84,114	cyclic AMP	corticotropin-releasing factor	MESH:D000242	81648(Tax:10116)	Chemical	Gene	accumulation|compound|START_ENTITY accumulation|nmod|END_ENTITY	Stimulation of cyclic_AMP accumulation and corticotropin release by synthetic ovine corticotropin-releasing_factor in rat anterior pituitary cells : site of glucocorticoid action .
6321447	0	cyclic_AMP	26,36	crp	70,73	cyclic AMP	crp	MESH:D000242	20468888	Chemical	Gene	synthesis|compound|START_ENTITY synthesis|nmod|END_ENTITY	Enzyme III stimulation of cyclic_AMP synthesis in an Escherichia_coli crp mutant .
2845936	0	cyclic_AMP	17,27	cyclic_AMP_receptor_protein	48,75	cyclic AMP	cyclic AMP receptor protein	MESH:D000242	20468888	Chemical	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Mutations in the cyclic_AMP binding site of the cyclic_AMP_receptor_protein of Escherichia_coli .
9535754	0	cyclic_AMP	22,32	cyclin_A	66,74	cyclic AMP	cyclin A	MESH:D000242	12428(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|nmod|gene gene|compound|END_ENTITY	Synergistic effect of cyclic_AMP and insulin on the expression of cyclin_A gene in Swiss_3T3 cells .
11526505	0	cyclic_AMP	8,18	cyclooxygenase-2	62,78	cyclic AMP	cyclooxygenase-2	MESH:D000242	5743	Chemical	Gene	Role|nmod|START_ENTITY responsive|nsubj|Role responsive|nmod|induction induction|nmod|transcription transcription|amod|END_ENTITY	Role of cyclic_AMP responsive element in the UVB induction of cyclooxygenase-2 transcription in human keratinocytes .
14670842	0	cyclic_AMP	78,88	cyclooxygenase-2	208,224	cyclic AMP	cyclooxygenase-2	MESH:D000242	5743	Chemical	Gene	production|compound|START_ENTITY smooth|nsubj|production smooth|advcl|prostacyclin prostacyclin|nmod|induction induction|amod|END_ENTITY	Interleukin-1beta , transforming_growth_factor-beta1 , and bradykinin attenuate cyclic_AMP production by human pulmonary artery smooth muscle cells in response to prostacyclin analogues and prostaglandin_E2 by cyclooxygenase-2 induction and downregulation of adenylyl cyclase isoforms 1 , 2 , and 4 .
16319525	0	cyclic_AMP	56,66	cyclooxygenase-2	24,40	cyclic AMP	cyclooxygenase-2	MESH:D000242	5743	Chemical	Gene	activation|compound|START_ENTITY expression|nmod|activation expression|amod|END_ENTITY	Prostaglandin_E2 drives cyclooxygenase-2 expression via cyclic_AMP response element activation in human pancreatic_cancer cells .
17945363	0	cyclic_AMP	45,55	cyclooxygenase-2	14,30	cyclic AMP	cyclooxygenase-2	MESH:D000242	5743	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of cyclooxygenase-2 expression by cyclic_AMP .
19797430	0	cyclic_AMP	80,90	cyclooxygenase-2	27,43	cyclic AMP	cyclooxygenase-2	MESH:D000242	5743	Chemical	Gene	element|compound|START_ENTITY glucocorticoids|nmod|element stimulation|nmod|glucocorticoids stimulation|nmod|expression expression|amod|END_ENTITY	Paradoxical stimulation of cyclooxygenase-2 expression by glucocorticoids via a cyclic_AMP response element in human amnion fibroblasts .
9388257	1	cyclic_AMP	142,152	cyclooxygenase-2	156,172	cyclic AMP	cyclooxygenase-2	MESH:D000242	19225(Tax:10090)	Chemical	Gene	action|nmod|START_ENTITY action|nmod|expression expression|amod|END_ENTITY	Synergistic action of cyclic_AMP on cyclooxygenase-2 expression and prostaglandin_E2 synthesis .
8276781	1	cyclic_AMP	111,121	cytochrome_c	125,137	cyclic AMP	cytochrome c	MESH:D000242	54205	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|expression expression|amod|END_ENTITY	Role of cyclic_AMP in cytochrome_c and COXIV gene expression .
7643093	0	cyclic_AMP	28,38	dopamine_D4_receptor	65,85	cyclic AMP	dopamine D4 receptor	MESH:D000242	1815	Chemical	Gene	levels|compound|START_ENTITY levels|nmod|END_ENTITY	Modulation of intracellular cyclic_AMP levels by different human dopamine_D4_receptor variants .
20045284	0	cyclic_AMP	98,108	endothelin-1	48,60	cyclic AMP	endothelin-1	MESH:D000242	1906	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nmod|END_ENTITY	Life cycle of human melanocytes is regulated by endothelin-1 and stem_cell_factor in synergy with cyclic_AMP and basic_fibroblast_growth_factor .
10779323	0	cyclic_AMP	12,22	epidermal_growth_factor	184,207	cyclic AMP	epidermal growth factor	MESH:D000242	1950	Chemical	Gene	element|compound|START_ENTITY Role|nmod|element alpha|nsubj|Role alpha|nmod|END_ENTITY	Role of the cyclic_AMP response element binding complex and activation of mitogen-activated protein kinases in synergistic activation of the glycoprotein hormone alpha subunit gene by epidermal_growth_factor and forskolin .
12792480	0	cyclic_AMP	16,26	epidermal_growth_factor	56,79	cyclic AMP	epidermal growth factor	MESH:D000242	100008808(Tax:9986)	Chemical	Gene	START_ENTITY|nmod|effect effect|nmod|END_ENTITY	Potentiation by cyclic_AMP of the stimulatory effect of epidermal_growth_factor on corneal epithelial migration .
6321523	0	cyclic_AMP	81,91	epidermal_growth_factor	43,66	cyclic AMP	epidermal growth factor	MESH:D000242	1950	Chemical	Gene	related|xcomp|START_ENTITY related|nsubjpass|sensitivity sensitivity|nmod|fibroblasts fibroblasts|nmod|END_ENTITY	Differential sensitivity of fibroblasts to epidermal_growth_factor is related to cyclic_AMP concentration .
9364843	0	cyclic_AMP	104,114	erythropoietin	118,132	cyclic AMP	erythropoietin	MESH:D000242	13856(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	-LSB- Establishment and characterization of a renal_carcinoma cell line producing erythropoietin -LRB- effects of cyclic_AMP on erythropoietin production in vitro -RRB- -RSB- .
9364843	0	cyclic_AMP	104,114	erythropoietin	77,91	cyclic AMP	erythropoietin	MESH:D000242	13856(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY characterization|dep|effects characterization|nmod|END_ENTITY	-LSB- Establishment and characterization of a renal_carcinoma cell line producing erythropoietin -LRB- effects of cyclic_AMP on erythropoietin production in vitro -RRB- -RSB- .
173160	0	cyclic_AMP	38,48	growth_hormone	20,34	cyclic AMP	growth hormone	MESH:D000242	81668(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	In vitro effects of growth_hormone on cyclic_AMP metabolism in the isolated rat diaphragm .
2163609	0	cyclic_AMP	99,109	growth_hormone	27,41	cyclic AMP	growth hormone	MESH:D000242	81668(Tax:10116)	Chemical	Gene	opposed|nmod|START_ENTITY opposed|nsubjpass|effect effect|nmod|END_ENTITY	The insulin-like effect of growth_hormone on insulin-like growth factor II receptors is opposed by cyclic_AMP .
2427292	0	cyclic_AMP	74,84	growth_hormone	14,28	cyclic AMP	growth hormone	MESH:D000242	81668(Tax:10116)	Chemical	Gene	mRNA|nmod|START_ENTITY mRNA|amod|END_ENTITY	Regulation of growth_hormone mRNA and pro-opiomelanocortin mRNA levels by cyclic_AMP in rat anterior pituitary cells in culture .
4364712	0	cyclic_AMP	31,41	growth_hormone	77,91	cyclic AMP	growth hormone	MESH:D000242	2688	Chemical	Gene	derivative|nmod|START_ENTITY Effect|nmod|derivative Effect|nmod|liberation liberation|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Effect of a new derivative of cyclic_AMP on the liberation and synthesis of growth_hormone and pituitary prolactin -RSB- .
6093953	0	cyclic_AMP	10,20	growth_hormone	68,82	cyclic AMP	growth hormone	MESH:D000242	81668(Tax:10116)	Chemical	Gene	Roles|nmod|START_ENTITY Roles|nmod|mechanism mechanism|nmod|release release|nmod|END_ENTITY	-LSB- Roles of cyclic_AMP and calcium in the mechanism of the release of growth_hormone by somatocrinin -RSB- .
8392063	0	cyclic_AMP	47,57	growth_hormone	108,122	cyclic AMP	growth hormone	MESH:D000242	81668(Tax:10116)	Chemical	Gene	interactions|nmod|START_ENTITY interactions|dep|elements elements|nmod|promoter promoter|compound|END_ENTITY	Distance-dependent interactions between basal , cyclic_AMP , and thyroid hormone response elements in the rat growth_hormone promoter .
8738864	0	cyclic_AMP	15,25	growth_hormone	125,139	cyclic AMP	growth hormone	MESH:D000242	443329(Tax:9940)	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|regulation regulation|nmod|END_ENTITY	Interaction of cyclic_AMP - and calcium-dependent mechanisms in the regulation of growth_hormone-releasing_hormone-stimulated growth_hormone release from ovine pituitary cells .
1336530	0	cyclic_AMP	11,21	hCG	39,42	cyclic AMP	hCG	MESH:D000242	93659	Chemical	Gene	START_ENTITY|nmod|transcription transcription|compound|END_ENTITY	-LSB- Effect of cyclic_AMP and adenosine on hCG transcription by trophoblast cells -RSB- .
10409662	0	cyclic_AMP	4,14	insulin	63,70	cyclic AMP	insulin	MESH:D000242	3630	Chemical	Gene	family|amod|START_ENTITY regulates|nsubj|family regulates|dobj|transcription transcription|compound|END_ENTITY	The cyclic_AMP response element modulator family regulates the insulin gene transcription by interacting with transcription factor IID .
164474	0	cyclic_AMP	65,75	insulin	14,21	cyclic AMP	insulin	MESH:D000242	3630	Chemical	Gene	content|compound|START_ENTITY effect|nmod|content effect|nmod|END_ENTITY	The effect of insulin on basal and hormone-induced elevations of cyclic_AMP content in cultured human fibroblasts .
198651	0	cyclic_AMP	13,23	insulin	42,49	cyclic AMP	insulin	MESH:D000242	3630	Chemical	Gene	role|nmod|START_ENTITY -LSB-|dobj|role -LSB-|nmod|control control|nmod|secretion secretion|compound|END_ENTITY	-LSB- The role of cyclic_AMP in the control of insulin secretion -LRB- author 's transl -RRB- -RSB- .
4375573	0	cyclic_AMP	80,90	insulin	37,44	cyclic AMP	insulin	MESH:D000242	3630	Chemical	Gene	volumes|compound|START_ENTITY stimulation|nmod|volumes stimulation|nmod|secretion secretion|compound|END_ENTITY	-LSB- Proceedings : Glucose stimulation of insulin secretion and resultant changes of cyclic_AMP volumes in the Langerhans ' islands -RSB- .
8702397	0	cyclic_AMP	88,98	insulin	56,63	cyclic AMP	insulin	MESH:D000242	3630	Chemical	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Glucose-dependent_insulinotropic_polypeptide stimulates insulin secretion via increased cyclic_AMP and -LSB- Ca2 + -RSB- 1 and a wortmannin-sensitive signalling pathway .
8396165	0	cyclic_AMP	24,34	interferon-gamma	77,93	cyclic AMP	interferon-gamma	MESH:D000242	3458	Chemical	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Modulation of leukocyte cyclic_AMP phosphodiesterase activity by recombinant interferon-gamma : evidence for a differential effect on atopic monocytes .
10027094	0	cyclic_AMP	44,54	interleukin-10	11,25	cyclic AMP	interleukin-10	MESH:D000242	25325(Tax:10116)	Chemical	Gene	formation|compound|START_ENTITY Effects|nmod|formation Effects|nmod|END_ENTITY	Effects of interleukin-10 and modulators of cyclic_AMP formation on endotoxin-induced inflammation in rat lung .
1648978	0	cyclic_AMP	36,46	jun-B	14,19	cyclic AMP	jun-B	MESH:D000242	3726	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of jun-B expression by a cyclic_AMP -LRB- cAMP -RRB- - dependent mechanism in human myeloid cells .
181189	0	cyclic_AMP	15,25	leucocyte_inhibitory_factor	29,56	cyclic AMP	leucocyte inhibitory factor	MESH:D000242	3976	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|production production|compound|END_ENTITY	The effects of cyclic_AMP on leucocyte_inhibitory_factor -LRB- LIF -RRB- production and on the inhibition of leucocyte migration .
6312718	0	cyclic_AMP	59,69	multiplication-stimulating_activity	10,45	cyclic AMP	multiplication-stimulating activity	MESH:D000242	24483(Tax:10116)	Chemical	Gene	level|compound|START_ENTITY Effect|nmod|level Effect|nmod|END_ENTITY	Effect of multiplication-stimulating_activity -LRB- MSA -RRB- on the cyclic_AMP level and proteoglycan synthesis in cultured chondrocytes .
7519273	0	cyclic_AMP	80,90	myelin_associated_glycoprotein	30,60	cyclic AMP	myelin associated glycoprotein	MESH:D000242	29409(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Transcriptional regulation of myelin_associated_glycoprotein gene expression by cyclic_AMP .
1848561	0	cyclic_AMP	123,133	myosin	71,77	cyclic AMP	myosin	MESH:D000242	79784	Chemical	Gene	mediation|nmod|START_ENTITY END_ENTITY|dep|mediation	Parathyroid_hormone promotes the disassembly of cytoskeletal actin and myosin in cultured osteoblastic cells : mediation by cyclic_AMP .
6322302	0	cyclic_AMP	76,86	myosin_light_chain_kinase	29,54	cyclic AMP	myosin light chain kinase	MESH:D000242	4638	Chemical	Gene	increase|nmod|START_ENTITY END_ENTITY|nmod|increase	Increased phosphorylation of myosin_light_chain_kinase after an increase in cyclic_AMP in intact smooth muscle .
17059558	0	cyclic_AMP	30,40	nerve_growth_factor	164,183	cyclic AMP	nerve growth factor	MESH:D000242	310738(Tax:10116)	Chemical	Gene	regulate|dobj|START_ENTITY regulate|nmod|END_ENTITY	PC12 cells regulate inducible cyclic_AMP -LRB- cAMP -RRB- element repressor expression to differentially control cAMP response element-dependent transcription in response to nerve_growth_factor and cAMP .
2174743	0	cyclic_AMP	45,55	nerve_growth_factor	60,79	cyclic AMP	nerve growth factor	MESH:D000242	310738(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Beta-adrenergic receptor regulation , through cyclic_AMP , of nerve_growth_factor expression in rat cortical and cerebellar astrocytes .
2571678	0	cyclic_AMP	24,34	nerve_growth_factor	60,79	cyclic AMP	nerve growth factor	MESH:D000242	310738(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|induction induction|compound|END_ENTITY	Increased intracellular cyclic_AMP differentially modulates nerve_growth_factor induction of three neuronal recognition molecules involved in neurite outgrowth .
23182882	0	cyclic_AMP	56,66	neuroglobin	36,47	cyclic AMP	neuroglobin	MESH:D000242	64242(Tax:10090)	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Transcriptional regulation of mouse neuroglobin gene by cyclic_AMP responsive element binding protein -LRB- CREB -RRB- in N2a cells .
3035437	0	cyclic_AMP	40,50	neuropeptide_Y	22,36	cyclic AMP	neuropeptide Y	MESH:D000242	24604(Tax:10116)	Chemical	Gene	accumulation|compound|START_ENTITY END_ENTITY|nmod|accumulation	Inhibitory effects of neuropeptide_Y on cyclic_AMP accumulation in slices of the nucleus tractus solitarius region of the rat .
1359985	0	cyclic_AMP	127,137	parathyroid_hormone	54,73	cyclic AMP	parathyroid hormone	MESH:D000242	24694(Tax:10116)	Chemical	Gene	resistant|nmod|START_ENTITY cells|amod|resistant blocked|nmod|cells blocked|nsubjpass|Regulation Regulation|nmod|transcription transcription|nmod|END_ENTITY	Regulation of gene transcription and proliferation by parathyroid_hormone is blocked in mutant osteoblastic cells resistant to cyclic_AMP .
1645284	0	cyclic_AMP	163,173	parathyroid_hormone	15,34	cyclic AMP	parathyroid hormone	MESH:D000242	280903(Tax:9913)	Chemical	Gene	mechanism|amod|START_ENTITY mediated|nmod|mechanism mediated|nsubjpass|effects effects|nmod|currents currents|amod|END_ENTITY	The effects of parathyroid_hormone on L-type voltage-dependent calcium channel currents in vascular smooth muscle cells and ventricular myocytes are mediated by a cyclic_AMP dependent mechanism .
1662087	0	cyclic_AMP	54,64	parathyroid_hormone	77,96	cyclic AMP	parathyroid hormone	MESH:D000242	19226(Tax:10090)	Chemical	Gene	response|compound|START_ENTITY enhance|dobj|response enhance|nmod|END_ENTITY	Protein kinase C activating phorbolesters enhance the cyclic_AMP response to parathyroid_hormone , forskolin and choleratoxin in mouse calvarial bones and rat_osteosarcoma cells .
171152	0	cyclic_AMP	54,64	parathyroid_hormone	11,30	cyclic AMP	parathyroid hormone	MESH:D000242	24694(Tax:10116)	Chemical	Gene	accumulation|nmod|START_ENTITY Effects|nmod|accumulation Effects|nmod|END_ENTITY	Effects of parathyroid_hormone on the accumulation of cyclic_AMP in bone of vitamin_D-deficient rats .
177154	0	cyclic_AMP	110,120	parathyroid_hormone	34,53	cyclic AMP	parathyroid hormone	MESH:D000242	280903(Tax:9913)	Chemical	Gene	excretion|nmod|START_ENTITY effects|nmod|excretion effects|nmod|END_ENTITY	Early effects of synthetic bovine parathyroid_hormone and synthetic salmon calcitonin on urinary excretion of cyclic_AMP , phosphate and calcium in man .
191763	0	cyclic_AMP	77,87	parathyroid_hormone	20,39	cyclic AMP	parathyroid hormone	MESH:D000242	24694(Tax:10116)	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction between parathyroid_hormone and catecholamines on renal cortical cyclic_AMP .
195984	0	cyclic_AMP	34,44	parathyroid_hormone	11,30	cyclic AMP	parathyroid hormone	MESH:D000242	5741	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of parathyroid_hormone on cyclic_AMP , cyclic_GMP , and efflux of calcium in isolated renal tubules .
1963873	0	cyclic_AMP	32,42	parathyroid_hormone	58,77	cyclic AMP	parathyroid hormone	MESH:D000242	5741	Chemical	Gene	production|nmod|START_ENTITY Comparison|nmod|production Comparison|acl|END_ENTITY	Comparison of the production of cyclic_AMP in response to parathyroid_hormone in fibroblasts from aged subjects and young subjects : lack of an age-dependent decrease .
211236	0	cyclic_AMP	12,22	parathyroid_hormone	26,45	cyclic AMP	parathyroid hormone	MESH:D000242	5741	Chemical	Gene	role|nmod|START_ENTITY role|nmod|action action|amod|END_ENTITY	The role of cyclic_AMP in parathyroid_hormone action in the toad bladder .
228881	0	cyclic_AMP	19,29	parathyroid_hormone	51,70	cyclic AMP	parathyroid hormone	MESH:D000242	5741	Chemical	Gene	excretion|compound|START_ENTITY Changes|nmod|excretion END_ENTITY|nsubj|Changes	Changes of urinary cyclic_AMP excretion and plasma parathyroid_hormone levels before and after parathyroidectomy in patients with primary_hyperparathyroidism .
2409973	0	cyclic_AMP	110,120	parathyroid_hormone	17,36	cyclic AMP	parathyroid hormone	MESH:D000242	396436(Tax:9031)	Chemical	Gene	involvement|nmod|START_ENTITY effect|dep|involvement effect|nmod|END_ENTITY	Direct effect of parathyroid_hormone on the proliferation of osteoblast-like cells ; a possible involvement of cyclic_AMP .
2414115	0	cyclic_AMP	10,20	parathyroid_hormone	97,116	cyclic AMP	parathyroid hormone	MESH:D000242	280903(Tax:9913)	Chemical	Gene	smooth|nsubj|START_ENTITY smooth|nmod|END_ENTITY	Increased cyclic_AMP in cultured vascular smooth muscle cells and relaxation of aortic strips by parathyroid_hormone .
2443515	0	cyclic_AMP	62,72	parathyroid_hormone	27,46	cyclic AMP	parathyroid hormone	MESH:D000242	5741	Chemical	Gene	stimulation|nmod|START_ENTITY stimulation|amod|END_ENTITY	Effect of dexamethasone on parathyroid_hormone stimulation of cyclic_AMP in an opossum kidney cell line .
2555146	0	cyclic_AMP	68,78	parathyroid_hormone	101,120	cyclic AMP	parathyroid hormone	MESH:D000242	5741	Chemical	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	Pseudohypoparathyroidism showing positive phosphaturic and negative cyclic_AMP excretion response to parathyroid_hormone .
2556491	0	cyclic_AMP	63,73	parathyroid_hormone	32,51	cyclic AMP	parathyroid hormone	MESH:D000242	5741	Chemical	Gene	production|compound|START_ENTITY stimulated|dobj|production stimulated|nsubj|Influence Influence|nmod|toxin toxin|nmod|END_ENTITY	Influence of pertussis toxin on parathyroid_hormone stimulated cyclic_AMP production and phosphate transport in opossum kidney cells .
3013322	0	cyclic_AMP	61,71	parathyroid_hormone	84,103	cyclic AMP	parathyroid hormone	MESH:D000242	24694(Tax:10116)	Chemical	Gene	response|compound|START_ENTITY D-3|nmod|response desensitization|nmod|D-3 desensitization|xcomp|END_ENTITY	Heterologous desensitization by 1,25-dihydroxyvitamin _ D-3 of cyclic_AMP response to parathyroid_hormone in osteoblast-like cells and the role of the stimulatory guanine_nucleotide regulatory protein .
6246701	0	cyclic_AMP	64,74	parathyroid_hormone	20,39	cyclic AMP	parathyroid hormone	MESH:D000242	24694(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY Interaction|nmod|metabolism Interaction|nmod|END_ENTITY	Interaction between parathyroid_hormone and prostaglandin_E1 on cyclic_AMP metabolism in rat kidney .
6247360	0	cyclic_AMP	22,32	parathyroid_hormone	51,70	cyclic AMP	parathyroid hormone	MESH:D000242	5741	Chemical	Gene	nephrogenous|dobj|START_ENTITY nephrogenous|nmod|levels levels|compound|END_ENTITY	Elevated nephrogenous cyclic_AMP with normal serum parathyroid_hormone levels in patients with lung_cancer .
6275968	0	cyclic_AMP	19,29	parathyroid_hormone	42,61	cyclic AMP	parathyroid hormone	MESH:D000242	396436(Tax:9031)	Chemical	Gene	response|compound|START_ENTITY Development|nmod|response Development|nmod|END_ENTITY	Development of the cyclic_AMP response to parathyroid_hormone and prostaglandin_E2 in the embryonic chick limb .
6280244	0	cyclic_AMP	78,88	parathyroid_hormone	21,40	cyclic AMP	parathyroid hormone	MESH:D000242	5741	Chemical	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions between parathyroid_hormone and prostaglandins on renal cortical cyclic_AMP .
6301744	0	cyclic_AMP	14,24	parathyroid_hormone	44,63	cyclic AMP	parathyroid hormone	MESH:D000242	280903(Tax:9913)	Chemical	Gene	response|compound|START_ENTITY Impairment|nmod|response Impairment|acl|END_ENTITY	Impairment of cyclic_AMP response to bovine parathyroid_hormone in patients on chronic lithium therapy with diminished renal urine-concentrating ability .
6330514	0	cyclic_AMP	71,81	parathyroid_hormone	11,30	cyclic AMP	parathyroid hormone	MESH:D000242	100351309(Tax:9986)	Chemical	Gene	patterns|nmod|START_ENTITY END_ENTITY|nmod|patterns	Effects of parathyroid_hormone and calcitonin on stop-flow patterns of cyclic_AMP , sodium , potassium , calcium and inorganic phosphate in thyroparathyroidectomized rabbits .
7817824	0	cyclic_AMP	24,34	parathyroid_hormone	47,66	cyclic AMP	parathyroid hormone	MESH:D000242	24694(Tax:10116)	Chemical	Gene	response|compound|START_ENTITY analysis|nmod|response analysis|acl|END_ENTITY	Single-cell analysis of cyclic_AMP response to parathyroid_hormone in osteoblastic cells .
93016	0	cyclic_AMP	30,40	parathyroid_hormone	53,72	cyclic AMP	parathyroid hormone	MESH:D000242	5741	Chemical	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	Regulation of hormone-induced cyclic_AMP response to parathyroid_hormone and prostaglandin_E2 in cells cultured from human giant_cell_tumors of bone .
1310016	0	cyclic_AMP	106,116	parathyroid_hormone-related_protein	67,102	cyclic AMP	parathyroid hormone-related protein	MESH:D000242	5744	Chemical	Gene	formation|compound|START_ENTITY END_ENTITY|nmod|formation	Tumor_necrosis_factor_alpha inhibits the stimulatory effect of the parathyroid_hormone-related_protein on cyclic_AMP formation in osteoblast-like cells via protein kinase C + .
10389149	0	cyclic_AMP	84,94	pituitary_adenylate_cyclase-activating_polypeptide	22,72	cyclic AMP	pituitary adenylate cyclase-activating polypeptide	MESH:D000242	24166(Tax:10116)	Chemical	Gene	formation|compound|START_ENTITY effect|nmod|formation effect|nmod|END_ENTITY	Stimulatory effect of pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- on cyclic_AMP formation in the hypothalamus and cerebral cortex of four avians and rat .
10909177	0	cyclic_AMP	73,83	pituitary_adenylate_cyclase-activating_polypeptide	11,61	cyclic AMP	pituitary adenylate cyclase-activating polypeptide	MESH:D000242	101800734	Chemical	Gene	formation|compound|START_ENTITY Effects|nmod|formation Effects|nmod|END_ENTITY	Effects of pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- on cyclic_AMP formation in the duck and goose brain .
8394344	0	cyclic_AMP	85,95	platelet-activating_factor_receptor	30,65	cyclic AMP	platelet-activating factor receptor	MESH:D000242	5724	Chemical	Gene	modulation|nmod|START_ENTITY modulation|nmod|expression expression|amod|END_ENTITY	Transcriptional modulation of platelet-activating_factor_receptor gene expression by cyclic_AMP .
177274	0	cyclic_AMP	19,29	prolactin	91,100	cyclic AMP	prolactin	MESH:D000242	24683(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|release release|compound|END_ENTITY	A possible role of cyclic_AMP in mediating the effects of thyrotropin-releasing_hormone on prolactin release and on prolactin and growth_hormone synthesis in pituitary cells in culture .
2157454	0	cyclic_AMP	54,64	proline-rich_protein	14,34	cyclic AMP	proline-rich protein	MESH:D000242	287750(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of proline-rich_protein gene expression by cyclic_AMP in primary cultures of hamster parotid glands .
168058	0	cyclic_AMP	15,25	renin	78,83	cyclic AMP	renin	MESH:D000242	24715(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|release release|compound|END_ENTITY	The effects of cyclic_AMP , theophylline , angiotensin_II and electrolytes upon renin release from rat kidney slices .
173476	0	cyclic_AMP	103,113	renin	122,127	cyclic AMP	renin	MESH:D000242	5972	Chemical	Gene	monophosphate|appos|START_ENTITY monophosphate|nmod|END_ENTITY	Contrasting effects of hypoglycemia on plasma renin activity and cyclic_adenosine_3 ' ,5 ' - monophosphate -LRB- cyclic_AMP -RRB- in low renin and normal renin essential hypertension .
173476	0	cyclic_AMP	103,113	renin	46,51	cyclic AMP	renin	MESH:D000242	5972	Chemical	Gene	monophosphate|appos|START_ENTITY Contrasting|dep|monophosphate Contrasting|nmod|activity activity|compound|END_ENTITY	Contrasting effects of hypoglycemia on plasma renin activity and cyclic_adenosine_3 ' ,5 ' - monophosphate -LRB- cyclic_AMP -RRB- in low renin and normal renin essential hypertension .
6278351	0	cyclic_AMP	17,27	renin	98,103	cyclic AMP	renin	MESH:D000242	24715(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY levels|nmod|areas areas|nmod|injection injection|nmod|END_ENTITY	Acute changes in cyclic_AMP levels of certain brain areas following intraventricular injection of renin in rats .
8166700	0	cyclic_AMP	18,28	renin	59,64	cyclic AMP	renin	MESH:D000242	5972	Chemical	Gene	element|compound|START_ENTITY Identification|nmod|element Identification|nmod|gene gene|compound|END_ENTITY	Identification of cyclic_AMP response element in the human renin gene .
8391804	0	cyclic_AMP	131,141	renin	20,25	cyclic AMP	renin	MESH:D000242	5972	Chemical	Gene	C|compound|START_ENTITY effect|nmod|C Regulation|dep|effect Regulation|nmod|secretion secretion|compound|END_ENTITY	Regulation of human renin secretion and renin transcription by quantitative PCR in cultured chorionic cells : synergistic effect of cyclic_AMP and protein kinase C .
8645191	0	cyclic_AMP	53,63	renin	39,44	cyclic AMP	renin	MESH:D000242	5972	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Transcriptional induction of the human renin gene by cyclic_AMP requires cyclic_AMP response element-binding protein -LRB- CREB -RRB- and a factor binding a pituitary-specific trans-acting factor -LRB- Pit-1 -RRB- motif .
8645191	0	cyclic_AMP	73,83	renin	39,44	cyclic AMP	renin	MESH:D000242	5972	Chemical	Gene	requires|ccomp|START_ENTITY requires|nsubj|induction induction|nmod|gene gene|compound|END_ENTITY	Transcriptional induction of the human renin gene by cyclic_AMP requires cyclic_AMP response element-binding protein -LRB- CREB -RRB- and a factor binding a pituitary-specific trans-acting factor -LRB- Pit-1 -RRB- motif .
8999953	0	cyclic_AMP	51,61	renin	29,34	cyclic AMP	renin	MESH:D000242	5972	Chemical	Gene	Transactivation|nmod|START_ENTITY Transactivation|nmod|promoter promoter|compound|END_ENTITY	Transactivation of the human renin promoter by the cyclic_AMP / protein kinase A pathway is mediated by both cAMP-responsive_element_binding_protein-1 -LRB- CREB -RRB- - dependent and CREB-independent mechanisms in Calu-6 cells .
7969075	0	cyclic_AMP	69,79	secretogranin_II	30,46	cyclic AMP	secretogranin II	MESH:D000242	24765(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of secretogranin_II and chromogranin_B by cyclic_AMP in a rat pheochromocytoma cell line .
15155837	0	cyclic_AMP	58,68	soluble_guanylyl_cyclase	19,43	cyclic AMP	soluble guanylyl cyclase	MESH:D000242	25206(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Down-regulation of soluble_guanylyl_cyclase expression by cyclic_AMP is mediated by mRNA-stabilizing protein HuR .
1659897	0	cyclic_AMP	78,88	sterol_carrier_protein_2	24,48	cyclic AMP	sterol carrier protein 2	MESH:D000242	25541(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY expression|dep|role expression|nmod|END_ENTITY	Regulated expression of sterol_carrier_protein_2 in the ovary : a key role for cyclic_AMP .
204777	0	cyclic_AMP	29,39	substance_P	14,25	cyclic AMP	substance P	MESH:D000242	6863	Chemical	Gene	levels|compound|START_ENTITY effect|nmod|levels effect|nmod|END_ENTITY	The effect of substance_P on cyclic_AMP and cyclic_GMP levels in actively secreting pancreatic lobules -LSB- proceedings -RSB- .
6188938	0	cyclic_AMP	36,46	substance_P	11,22	cyclic AMP	substance P	MESH:D000242	6863	Chemical	Gene	levels|compound|START_ENTITY END_ENTITY|nmod|levels	Effects of substance_P on thyroidal cyclic_AMP levels and thyroid hormone release from canine thyroid slices .
19632320	0	cyclic_AMP	84,94	suppressor_of_cytokine_signalling-3	128,163	cyclic AMP	suppressor of cytokine signalling-3	MESH:D000242	9021	Chemical	Gene	START_ENTITY|nmod|induction induction|nmod|END_ENTITY	Selective inhibition of cytokine-activated extracellular signal-regulated kinase by cyclic_AMP via Epac1-dependent induction of suppressor_of_cytokine_signalling-3 .
8840026	0	cyclic_AMP	78,88	synapsin_I	24,34	cyclic AMP	synapsin I	MESH:D000242	6853	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Long-term regulation of synapsin_I gene expression and neuronal morphology by cyclic_AMP and low-dose staurosporine .
1310010	0	cyclic_AMP	19,29	thrombin	43,51	cyclic AMP	thrombin	MESH:D000242	2147	Chemical	Gene	formation|compound|START_ENTITY regulation|nmod|formation regulation|nmod|END_ENTITY	Dual regulation of cyclic_AMP formation by thrombin in HEL cells , a leukaemic cell line with megakaryocytic properties .
2540378	0	cyclic_AMP	22,32	thrombin	10,18	cyclic AMP	thrombin	MESH:D000242	29251(Tax:10116)	Chemical	Gene	content|compound|START_ENTITY END_ENTITY|nmod|content	Effect of thrombin on cyclic_AMP content in glomeruli isolated from rat kidney .
6318378	0	cyclic_AMP	10,20	thrombin	82,90	cyclic AMP	thrombin	MESH:D000242	2147	Chemical	Gene	START_ENTITY|nmod|calcium calcium|nmod|platelets platelets|acl|stimulated stimulated|nmod|END_ENTITY	Effect of cyclic_AMP on cytoplasmic free calcium in human platelets stimulated by thrombin : direct measurement with quin2 .
9446794	0	cyclic_AMP	60,70	thyroglobulin	74,87	cyclic AMP	thyroglobulin	MESH:D000242	24826(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|transcription transcription|compound|END_ENTITY	TTF-2 does not appear to be a key mediator of the effect of cyclic_AMP on thyroglobulin gene transcription in primary cultured dog thyrocytes .
177274	0	cyclic_AMP	19,29	thyrotropin-releasing_hormone	58,87	cyclic AMP	thyrotropin-releasing hormone	MESH:D000242	25569(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A possible role of cyclic_AMP in mediating the effects of thyrotropin-releasing_hormone on prolactin release and on prolactin and growth_hormone synthesis in pituitary cells in culture .
192536	0	cyclic_AMP	60,70	thyrotropin_releasing_hormone	27,56	cyclic AMP	thyrotropin releasing hormone	MESH:D000242	25569(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY END_ENTITY|nmod|concentration	Effect of thyroxine and of thyrotropin_releasing_hormone on cyclic_AMP concentration in the anterior pituitary gland in vitro .
10355595	0	cyclic_AMP	74,84	tumor_necrosis_factor-alpha	14,41	cyclic AMP	tumor necrosis factor-alpha	MESH:D000242	7124	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Inhibition of tumor_necrosis_factor-alpha induced neutrophil apoptosis by cyclic_AMP : involvement of caspase cascade .
2153041	0	cyclic_AMP	101,111	tumor_necrosis_factor_alpha	11,38	cyclic AMP	tumor necrosis factor alpha	MESH:D000242	24835(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of tumor_necrosis_factor_alpha on parathyroid_hormone-induced increases in osteoblastic cell cyclic_AMP .
1345939	0	cyclic_AMP	29,39	tyrosine_hydroxylase	82,102	cyclic AMP	tyrosine hydroxylase	MESH:D000242	25085(Tax:10116)	Chemical	Gene	system|compound|START_ENTITY regulation|nmod|system regulation|nmod|coeruleus coeruleus|amod|END_ENTITY	Coordinate regulation of the cyclic_AMP system with firing rate and expression of tyrosine_hydroxylase in the rat locus coeruleus : effects of chronic stress and drug treatments .
1974315	0	cyclic_AMP	15,25	tyrosine_hydroxylase	66,86	cyclic AMP	tyrosine hydroxylase	MESH:D000242	25085(Tax:10116)	Chemical	Gene	contact|compound|START_ENTITY Interaction|nmod|contact Interaction|nmod|control control|nmod|RNA RNA|amod|END_ENTITY	Interaction of cyclic_AMP and cell-cell contact in the control of tyrosine_hydroxylase RNA .
7595476	0	cyclic_AMP	49,59	tyrosine_hydroxylase	20,40	cyclic AMP	tyrosine hydroxylase	MESH:D000242	25085(Tax:10116)	Chemical	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	The response of the tyrosine_hydroxylase gene to cyclic_AMP is mediated by two cyclic_AMP-response elements .
7665571	0	cyclic_AMP	4,14	tyrosine_hydroxylase	40,60	cyclic AMP	tyrosine hydroxylase	MESH:D000242	21823(Tax:10090)	Chemical	Gene	element|compound|START_ENTITY directs|nsubj|element directs|dobj|expression expression|amod|END_ENTITY	The cyclic_AMP response element directs tyrosine_hydroxylase expression in catecholaminergic central and peripheral nervous system cell lines from transgenic_mice .
2415168	0	cyclic_AMP	15,25	vasoactive_intestinal_polypeptide	79,112	cyclic AMP	vasoactive intestinal polypeptide	MESH:D000242	117064(Tax:10116)	Chemical	Gene	Involvement|nmod|START_ENTITY induced|nsubj|Involvement induced|nmod|END_ENTITY	Involvement of cyclic_AMP and calcium in exocrine protein secretion induced by vasoactive_intestinal_polypeptide in rat parotid cells .
2986998	0	cyclic_AMP	53,63	vasoactive_intestinal_polypeptide	10,43	cyclic AMP	vasoactive intestinal polypeptide	MESH:D000242	117064(Tax:10116)	Chemical	Gene	level|compound|START_ENTITY END_ENTITY|nmod|level	Effect of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- on cyclic_AMP level and relaxation in rat isolated aorta .
3036825	0	cyclic_AMP	109,119	vasoactive_intestinal_polypeptide	40,73	cyclic AMP	vasoactive intestinal polypeptide	MESH:D000242	7432	Chemical	Gene	responsible|nmod|START_ENTITY Identification|amod|responsible Identification|nmod|region region|nmod|gene gene|compound|END_ENTITY	Identification of a region in the human vasoactive_intestinal_polypeptide gene responsible for regulation by cyclic_AMP .
7682299	0	cyclic_AMP	74,84	vasoactive_intestinal_polypeptide	26,59	cyclic AMP	vasoactive intestinal polypeptide	MESH:D000242	117064(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Synergistic regulation of vasoactive_intestinal_polypeptide expression by cyclic_AMP and calcium in newborn but not adult rat sensory neurons in culture .
8177522	0	cyclic_AMP	42,52	vasoactive_intestinal_polypeptide	8,41	cyclic AMP	vasoactive intestinal polypeptide	MESH:D000242	117064(Tax:10116)	Chemical	Gene	element|compound|START_ENTITY element|amod|END_ENTITY	The rat vasoactive_intestinal_polypeptide cyclic_AMP response element regulates gene transcriptional responses differently in neonatal and adult rat sensory neurons .
1707518	0	cyclic_GMP	36,46	Atrial_natriuretic_factor	0,25	cyclic GMP	Atrial natriuretic factor	MESH:D006152	4878	Chemical	Gene	levels|compound|START_ENTITY increases|dobj|levels increases|nsubj|END_ENTITY	Atrial_natriuretic_factor increases cyclic_GMP and cyclic_AMP levels in a directly photosensitive pineal organ .
2877903	0	cyclic_GMP	55,65	Atrial_natriuretic_factor	0,25	cyclic GMP	Atrial natriuretic factor	MESH:D006152	24602(Tax:10116)	Chemical	Gene	formation|compound|START_ENTITY receptors|nmod|formation receptors|compound|END_ENTITY	Atrial_natriuretic_factor receptors and stimulation of cyclic_GMP formation in normal and malignant osteoblasts .
2992502	0	cyclic_GMP	36,46	Atrial_natriuretic_factor	0,25	cyclic GMP	Atrial natriuretic factor	MESH:D006152	24602(Tax:10116)	Chemical	Gene	increases|dobj|START_ENTITY increases|nsubj|END_ENTITY	Atrial_natriuretic_factor increases cyclic_GMP and inhibits cyclic_AMP in rat renal papillary collecting tubule cells in culture .
3007214	0	cyclic_GMP	40,50	Atrial_natriuretic_factor	0,25	cyclic GMP	Atrial natriuretic factor	MESH:D006152	24602(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY regulation|nmod|levels END_ENTITY|dobj|regulation	Atrial_natriuretic_factor regulation of cyclic_GMP levels and steroidogenesis in isolated fasciculata cells of rat adrenal cortex .
9676724	0	cyclic_GMP	92,102	Atrial_natriuretic_factor	0,25	cyclic GMP	Atrial natriuretic factor	MESH:D006152	4878	Chemical	Gene	mediated|nmod|START_ENTITY mediated|ccomp|reduces reduces|nsubj|END_ENTITY	Atrial_natriuretic_factor reduces cell coupling in the failing heart , an effect mediated by cyclic_GMP .
2156053	0	cyclic_GMP	40,50	Bradykinin	0,10	cyclic GMP	Bradykinin	MESH:D006152	3827	Chemical	Gene	production|nmod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Bradykinin stimulates the production of cyclic_GMP via activation of B2 kinin receptors in cultured porcine aortic endothelial cells .
2553081	4	cyclic_GMP	618,628	EDRF	653,657	cyclic GMP	EDRF	MESH:D006152	51327	Chemical	Gene	accumulation|compound|START_ENTITY accumulation|acl|induced induced|nmod|END_ENTITY	However , there have been few reports regarding cyclic_GMP accumulation induced by EDRF or GTN in canine cerebral arteries .
2555082	0	cyclic_GMP	15,25	EDRF	0,4	cyclic GMP	EDRF	MESH:D006152	51327	Chemical	Gene	increases|dobj|START_ENTITY increases|nsubj|END_ENTITY	EDRF increases cyclic_GMP in platelets during passage through the coronary vascular bed .
20649843	0	cyclic_GMP	51,61	ERK	83,86	cyclic GMP	ERK	MESH:D006152	24338(Tax:10116)	Chemical	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Midbrain dopaminergic neurons utilize nitric_oxide / cyclic_GMP signaling to recruit ERK that links retinoic_acid receptor stimulation to up-regulation of BDNF .
1725346	0	cyclic_GMP	24,34	Endothelin-1	0,12	cyclic GMP	Endothelin-1	MESH:D006152	396915(Tax:9823)	Chemical	Gene	formation|compound|START_ENTITY stimulates|dobj|formation stimulates|nsubj|END_ENTITY	Endothelin-1 stimulates cyclic_GMP formation in porcine kidney epithelial cells via activation of the L-arginine-dependent soluble guanylate cyclase pathway .
7679657	0	cyclic_GMP	30,40	Interleukin-1_beta	0,18	cyclic GMP	Interleukin-1 beta	MESH:D006152	24494(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|amod|END_ENTITY	Interleukin-1_beta effects on cyclic_GMP and cyclic_AMP in cultured rat islets of Langerhans-arginine-dependence and relationship to insulin secretion .
11518618	0	cyclic_GMP	50,60	Nitric_oxide_synthase	0,21	cyclic GMP	Nitric oxide synthase	MESH:D006152	396859(Tax:9823)	Chemical	Gene	pathway|compound|START_ENTITY pathway|dep|END_ENTITY	Nitric_oxide_synthase expression and nitric_oxide / cyclic_GMP pathway in swine granulosa cells .
2484708	0	cyclic_GMP	35,45	SIN-1	0,5	cyclic GMP	SIN-1	MESH:D006152	79109	Chemical	Gene	production|nmod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	SIN-1 stimulates the production of cyclic_GMP but not cyclic_AMP in porcine aortic endothelial cells .
7798914	0	cyclic_GMP	37,47	Serotonin_5-HT2C_receptor	0,25	cyclic GMP	Serotonin 5-HT2C receptor	MESH:D006152	3358	Chemical	Gene	formation|compound|START_ENTITY stimulates|dobj|formation stimulates|nsubj|END_ENTITY	Serotonin_5-HT2C_receptor stimulates cyclic_GMP formation in choroid plexus .
7690446	0	cyclic_GMP	22,32	Substance_P	0,11	cyclic GMP	Substance P	MESH:D006152	281512(Tax:9913)	Chemical	Gene	levels|compound|START_ENTITY increases|dobj|levels increases|nsubj|END_ENTITY	Substance_P increases cyclic_GMP levels on coronary postcapillary venular endothelial cells .
2430959	0	cyclic_GMP	8,18	atrial_natriuretic_factor	22,47	cyclic GMP	atrial natriuretic factor	MESH:D006152	24602(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|stimulation stimulation|compound|END_ENTITY	Role of cyclic_GMP in atrial_natriuretic_factor stimulation of Na + , K + , Cl - cotransport in vascular smooth muscle cells .
2440311	0	cyclic_GMP	22,32	atrial_natriuretic_factor	58,83	cyclic GMP	atrial natriuretic factor	MESH:D006152	4878	Chemical	Gene	accumulation|compound|START_ENTITY accumulation|acl|produced produced|nmod|END_ENTITY	Angiotensin decreases cyclic_GMP accumulation produced by atrial_natriuretic_factor .
2551548	0	cyclic_GMP	40,50	atrial_natriuretic_factor	11,36	cyclic GMP	atrial natriuretic factor	MESH:D006152	24602(Tax:10116)	Chemical	Gene	content|compound|START_ENTITY END_ENTITY|nmod|content	Effects of atrial_natriuretic_factor on cyclic_GMP content in the rat aortic smooth muscle : studies on the role of membrane Na + , K + - ATPase .
2551758	0	cyclic_GMP	44,54	atrial_natriuretic_factor	15,40	cyclic GMP	atrial natriuretic factor	MESH:D006152	4878	Chemical	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	Stimulation by atrial_natriuretic_factor of cyclic_GMP production in cultured anterior and intermediate pituitary tissues : evidence for a major contribution of proliferating nonendocrine cells .
2843190	0	cyclic_GMP	51,61	atrial_natriuretic_factor	22,47	cyclic GMP	atrial natriuretic factor	MESH:D006152	24602(Tax:10116)	Chemical	Gene	formation|compound|START_ENTITY END_ENTITY|nmod|formation	Binding and effect of atrial_natriuretic_factor on cyclic_GMP formation and alpha-MSH secretion of intermediate pituitary cells .
2997262	0	cyclic_GMP	37,47	atrial_natriuretic_factor	73,98	cyclic GMP	atrial natriuretic factor	MESH:D006152	4878	Chemical	Gene	increase|nmod|START_ENTITY increase|nmod|injection injection|nmod|END_ENTITY	Rapid increase in plasma and urinary cyclic_GMP after bolus injection of atrial_natriuretic_factor in man .
2998822	0	cyclic_GMP	81,91	atrial_natriuretic_factor	11,36	cyclic GMP	atrial natriuretic factor	MESH:D006152	24602(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY END_ENTITY|nmod|levels	Effects of atrial_natriuretic_factor , sodium_nitroprusside , and acetylcholine on cyclic_GMP levels and relaxation in rat aorta .
3016445	0	cyclic_GMP	21,31	atrial_natriuretic_factor	35,60	cyclic GMP	atrial natriuretic factor	MESH:D006152	24602(Tax:10116)	Chemical	Gene	increase|nmod|START_ENTITY increase|nmod|END_ENTITY	Regional increase of cyclic_GMP by atrial_natriuretic_factor in rat brain : markedly elevated response in spontaneously hypertensive rats .
3028372	0	cyclic_GMP	96,106	atrial_natriuretic_factor	24,49	cyclic GMP	atrial natriuretic factor	MESH:D006152	230899(Tax:10090)	Chemical	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|effect effect|nmod|END_ENTITY	Steroidogenic effect of atrial_natriuretic_factor in isolated mouse Leydig cells is mediated by cyclic_GMP .
6091631	0	cyclic_GMP	60,70	atrial_natriuretic_factor	31,56	cyclic GMP	atrial natriuretic factor	MESH:D006152	4878	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of native and synthetic atrial_natriuretic_factor on cyclic_GMP .
9420635	0	cyclic_GMP	14,24	atrial_natriuretic_factor	72,97	cyclic GMP	atrial natriuretic factor	MESH:D006152	608289(Tax:9615)	Chemical	Gene	phosphodiesterases|compound|START_ENTITY Inhibition|nmod|phosphodiesterases augments|nsubj|Inhibition augments|xcomp|END_ENTITY	Inhibition of cyclic_GMP phosphodiesterases augments renal responses to atrial_natriuretic_factor in congestive_heart_failure .
8727695	0	cyclic_GMP	75,85	atrial_natriuretic_peptide	37,63	cyclic GMP	atrial natriuretic peptide	MESH:D006152	24602(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY production|amod|END_ENTITY	PMA and ionomycin differently affect atrial_natriuretic_peptide stimulated cyclic_GMP production in rat mesangial cells .
9179384	0	cyclic_GMP	46,56	endothelinB_receptor	92,112	cyclic GMP	endothelinB receptor	MESH:D006152	50672(Tax:10116)	Chemical	Gene	increase|nmod|START_ENTITY increase|nmod|END_ENTITY	Cyclosporine_A-induced increase in glomerular cyclic_GMP in rats and the involvement of the endothelinB_receptor .
2876015	0	cyclic_GMP	8,18	gastrin	22,29	cyclic GMP	gastrin	MESH:D006152	25320(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Role of cyclic_GMP in gastrin secretion from rat antral mucosae in organ culture .
6243274	0	cyclic_GMP	59,69	gonadotropin_releasing_hormone	23,53	cyclic GMP	gonadotropin releasing hormone	MESH:D006152	2796	Chemical	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	Independent actions of gonadotropin_releasing_hormone upon cyclic_GMP production and luteinizing hormone release .
1675756	0	cyclic_GMP	47,57	growth_hormone-releasing_factor	4,35	cyclic GMP	growth hormone-releasing factor	MESH:D006152	29446(Tax:10116)	Chemical	Gene	formation|compound|START_ENTITY stimulates|dobj|formation stimulates|nsubj|END_ENTITY	Rat growth_hormone-releasing_factor stimulates cyclic_GMP formation and phosphatidylinositol metabolism in the median eminence .
7983143	0	cyclic_GMP	64,74	myosin	14,20	cyclic GMP	myosin	MESH:D006152	79784	Chemical	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Regulation of myosin regulatory light chain phosphorylation via cyclic_GMP during chemotaxis of Dictyostelium .
2544631	0	cyclic_adenosine_monophosphate	89,119	Angiotensin_II	0,14	cyclic adenosine monophosphate	Angiotensin II	null	24179(Tax:10116)	Chemical	Gene	stimulates|nmod|START_ENTITY stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates early proximal bicarbonate absorption in the rat by decreasing cyclic_adenosine_monophosphate .
16638588	0	cyclic_adenosine_monophosphate	73,103	Aquaporin_3	0,11	cyclic adenosine monophosphate	Aquaporin 3	null	360	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Aquaporin_3 expression in human fetal membranes and its up-regulation by cyclic_adenosine_monophosphate in amnion epithelial cell culture .
205567	1	cyclic_adenosine_monophosphate	64,94	B_cell_activation	104,121	cyclic adenosine monophosphate	B cell activation	null	29760	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	the regulatory effect of cyclic_adenosine_monophosphate on human B_cell_activation .
9639497	0	cyclic_adenosine_monophosphate	150,180	CCR5	131,135	cyclic adenosine monophosphate	CCR5	null	1234	Chemical	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Prostaglandin_E2 induces resistance to human_immunodeficiency_virus-1 infection in monocyte-derived macrophages : downregulation of CCR5 expression by cyclic_adenosine_monophosphate .
12658105	0	cyclic_adenosine_monophosphate	33,63	CREB	97,101	cyclic adenosine monophosphate	CREB	null	81646(Tax:10116)	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	The decreased phosphorylation of cyclic_adenosine_monophosphate -LRB- cAMP -RRB- response element binding -LRB- CREB -RRB- protein in the central amygdala acts as a molecular substrate for anxiety related to ethanol withdrawal in rats .
19709647	0	cyclic_adenosine_monophosphate	73,103	CREB	130,134	cyclic adenosine monophosphate	CREB	null	81646(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Environmental enrichment produces a behavioral phenotype mediated by low cyclic_adenosine_monophosphate response element binding -LRB- CREB -RRB- activity in the nucleus accumbens .
10638668	0	cyclic_adenosine_monophosphate	57,87	Cyclooxygenase_2	0,16	cyclic adenosine monophosphate	Cyclooxygenase 2	null	19225(Tax:10090)	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Cyclooxygenase_2 -LRB- COX-2 -RRB- gene activation is regulated by cyclic_adenosine_monophosphate .
12712100	0	cyclic_adenosine_monophosphate	51,81	aquaporin_8	14,25	cyclic adenosine monophosphate	aquaporin 8	null	343	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of aquaporin_8 and its up-regulation by cyclic_adenosine_monophosphate in human WISH cells .
2177866	1	cyclic_adenosine_monophosphate	193,223	cAMP	225,229	cyclic adenosine monophosphate	CGRP	null	796	Chemical	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Calcitonin_gene-related_peptide -LRB- CGRP -RRB- stimulated cyclic_adenosine_monophosphate -LRB- cAMP -RRB- levels in SK-N-MC human neuroblastoma cells in a time - and concentration-dependent manner .
183441	0	cyclic_adenosine_monophosphate	31,61	growth_hormone	100,114	cyclic adenosine monophosphate	growth hormone	null	2688	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Different effects of exogenous cyclic_adenosine_monophosphate and its dibutryl derivative on plasma growth_hormone , glucose , insulin and cortisol .
7711886	0	cyclic_adenosine_monophosphate	79,109	interleukin-1_beta	19,37	cyclic adenosine monophosphate	interleukin-1 beta	null	24494(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	Biphasic effect of interleukin-1_beta on arginine_vasopressin-induced cellular cyclic_adenosine_monophosphate production in cultured rat renal papillary collecting tubule cells .
24006303	0	cyclic_adenosine_monophosphate	115,145	protein_kinase_A	146,162	cyclic adenosine monophosphate	protein kinase A	null	25636(Tax:10116)	Chemical	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Intermedin1-53 attenuates vascular smooth muscle cell calcification by inhibiting endoplasmic_reticulum_stress via cyclic_adenosine_monophosphate / protein_kinase_A pathway .
8769368	0	cyclic_adenosine_monophosphate	49,79	somatostatin	14,26	cyclic adenosine monophosphate	somatostatin	null	20604(Tax:10090)	Chemical	Gene	transcription|nmod|START_ENTITY transcription|nsubj|Regulation Regulation|nmod|gene gene|compound|END_ENTITY	Regulation of somatostatin gene transcription by cyclic_adenosine_monophosphate .
11206457	0	cyclic_alkoxyketones	25,45	cathepsin_K	83,94	cyclic alkoxyketones	cathepsin K	null	1513	Chemical	Gene	synthesis|nmod|START_ENTITY END_ENTITY|nsubj|synthesis	Solid-phase synthesis of cyclic_alkoxyketones , inhibitors of the cysteine_protease cathepsin_K .
17985862	0	cyclic_amidine	73,87	beta-secretase	88,102	cyclic amidine	beta-secretase	null	23621	Chemical	Gene	START_ENTITY|dobj|inhibitors inhibitors|amod|END_ENTITY	Application of fragment-based lead generation to the discovery of novel , cyclic_amidine beta-secretase inhibitors with nanomolar potency , cellular activity , and high ligand efficiency .
2503906	0	cyclic_clofibric_acid	31,52	CPIB	54,58	cyclic clofibric acid	CPIB	null	1476	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Potent antiplatelet effects of cyclic_clofibric_acid -LRB- CPIB -RRB- analogs on human platelets .
21310957	0	cyclic_di-GMP	66,79	PA4608	46,52	cyclic di-GMP	PA4608	MESH:C062025	881102(Tax:208964)	Chemical	Gene	complex|nmod|START_ENTITY complex|compound|END_ENTITY	Solution structure of the PilZ domain protein PA4608 complex with cyclic_di-GMP identifies charge clustering as molecular readout .
26546220	0	cyclic_dipeptides	50,67	TNF-a	15,20	cyclic dipeptides	TNF-a	null	24835(Tax:10116)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|amod|END_ENTITY	Attenuation of TNF-a secretion by l-proline-based cyclic_dipeptides produced by culture broth of Pseudomonas_aeruginosa .
8843157	0	cyclic_dodecapeptide	10,30	neuropeptide_Y	41,55	cyclic dodecapeptide	neuropeptide Y	null	4852	Chemical	Gene	analog|amod|START_ENTITY analog|nmod|END_ENTITY	Modified , cyclic_dodecapeptide analog of neuropeptide_Y is the smallest full agonist at the human Y2 receptor .
2155874	0	cyclic_guanosine_monophosphate	82,112	atrial_natriuretic_factor	127,152	cyclic guanosine monophosphate	atrial natriuretic factor	null	24602(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	A functional parameter to study heterogeneity of glial cells in rat brain slices : cyclic_guanosine_monophosphate production in atrial_natriuretic_factor -LRB- ANF -RRB- - responsive cells .
10960723	0	cyclic_guanosine_monophosphate	48,78	endothelin-1	17,29	cyclic guanosine monophosphate	endothelin-1	null	1906	Chemical	Gene	START_ENTITY|nsubj|plasma plasma|amod|END_ENTITY	Increased plasma endothelin-1 and intraplatelet cyclic_guanosine_monophosphate in men with disturbed glucose metabolism .
21388807	0	cyclic_hydroxyethylamine	45,69	BACE-1	76,82	cyclic hydroxyethylamine	BACE-1	null	23621	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Structure based design , synthesis and SAR of cyclic_hydroxyethylamine -LRB- HEA -RRB- BACE-1 inhibitors .
21388719	0	cyclic_imides	86,99	COX-2	48,53	cyclic imides	COX-2	null	26198(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Synthesis , anti-inflammatory activity and COX-1 / COX-2 inhibition of novel substituted cyclic_imides .
16971130	0	cyclic_ketone	30,43	plasmin	78,85	cyclic ketone	plasmin	CHEBI:3992	5340	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Structure-activity studies of cyclic_ketone inhibitors of the serine protease plasmin : design , synthesis , and biological activity .
19686719	0	cyclic_nucleotide	51,68	PKG	138,141	cyclic nucleotide	PKG	CHEBI:23447	5592	Chemical	Gene	type|amod|START_ENTITY type|appos|END_ENTITY	The flavonoid_dioclein is a selective inhibitor of cyclic_nucleotide phosphodiesterase type 1 -LRB- PDE1 -RRB- and a cGMP-dependent protein kinase -LRB- PKG -RRB- vasorelaxant in human vascular tissue .
6096994	0	cyclic_nucleotide	71,88	estradiol_receptor	22,40	cyclic nucleotide	estradiol receptor	D009712	24890(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY END_ENTITY|nmod|inhibition	-LSB- Participation of the estradiol_receptor in the hormonal inhibition of cyclic_nucleotide phosphodiesterase in the uterus -RSB- .
6301159	0	cyclic_nucleotides	10,28	ATPase	46,52	cyclic nucleotides	ATPase	MESH:D009712	1769	Chemical	Gene	START_ENTITY|appos|activity activity|compound|END_ENTITY	-LSB- Level of cyclic_nucleotides -LRB- cAMP and cGMP -RRB- , ATPase activity and calcium ion transport in hamster lymphocytes during tumor growth -RSB- .
229699	0	cyclic_nucleotides	14,32	CSF	0,3	cyclic nucleotides	CSF	MESH:D009712	1437	Chemical	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	CSF levels of cyclic_nucleotides in primary intracranial_neoplasms : a preliminary report .
6155709	0	cyclic_nucleotides	14,32	CSF	0,3	cyclic nucleotides	CSF	MESH:D009712	1437	Chemical	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	CSF levels of cyclic_nucleotides and adrenergic metabolites in malignant_gliomas .
12637526	0	cyclic_nucleotides	61,79	MRP4	24,28	cyclic nucleotides	MRP4	MESH:D009712	10257	Chemical	Gene	transport|nmod|START_ENTITY transport|amod|END_ENTITY	Characterization of the MRP4 - and MRP5-mediated transport of cyclic_nucleotides from intact cells .
2833439	0	cyclic_nucleotides	56,74	atrial_natriuretic_factor	11,36	cyclic nucleotides	atrial natriuretic factor	MESH:D009712	4878	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of atrial_natriuretic_factor and vasopressin on cyclic_nucleotides in cultured kidney cells .
196678	0	cyclic_nucleotides	10,28	galactosyltransferase	58,79	cyclic nucleotides	galactosyltransferase	MESH:D009712	246766(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of cyclic_nucleotides in vitro assays of rat liver galactosyltransferase .
11447229	0	cyclic_nucleotides	13,31	multidrug_resistance_protein_4	71,101	cyclic nucleotides	multidrug resistance protein 4	MESH:D009712	10257	Chemical	Gene	Transport|nmod|START_ENTITY Transport|nmod|END_ENTITY	Transport of cyclic_nucleotides and estradiol_17-beta-D-glucuronide by multidrug_resistance_protein_4 .
3011576	0	cyclic_nucleotides	11,29	pepsinogen	75,85	cyclic nucleotides	pepsinogen	MESH:D009712	100328625(Tax:9986)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of cyclic_nucleotides , betazole_hydrochloride and acetylcholine on pepsinogen secretion from isolated rabbit gastric mucosa .
6139495	0	cyclic_nucleotides	31,49	thyrotropin-releasing_hormone	53,82	cyclic nucleotides	thyrotropin-releasing hormone	MESH:D009712	25569(Tax:10116)	Chemical	Gene	Increase|nmod|START_ENTITY Increase|nmod|END_ENTITY	Increase in rat regional brain cyclic_nucleotides by thyrotropin-releasing_hormone -LRB- TRH -RRB- and its analog DN-1417 .
22380629	0	cyclic_sulfone_hydroxyethylamines	13,46	b-site_APP-cleaving_enzyme_1	71,99	cyclic sulfone hydroxyethylamines	b-site APP-cleaving enzyme 1	null	23821(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Discovery of cyclic_sulfone_hydroxyethylamines as potent and selective b-site_APP-cleaving_enzyme_1 -LRB- BACE1 -RRB- inhibitors : structure-based design and in vivo reduction of amyloid b-peptides .
22765900	0	cyclic_sulfones	28,43	mTOR	68,72	cyclic sulfones	mTOR	null	21977(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|kinase kinase|compound|END_ENTITY	Conformationally-restricted cyclic_sulfones as potent and selective mTOR kinase inhibitors .
23981898	0	cyclic_sulfoxide_hydroxyethylamines	13,48	b-site_APP-cleaving_enzyme_1	73,101	cyclic sulfoxide hydroxyethylamines	b-site APP-cleaving enzyme 1	null	23821(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Discovery of cyclic_sulfoxide_hydroxyethylamines as potent and selective b-site_APP-cleaving_enzyme_1 -LRB- BACE1 -RRB- inhibitors : structure based design and in vivo reduction of amyloid b-peptides .
15109626	0	cyclic_tetrapeptides	57,77	histone_deacetylase	14,33	cyclic tetrapeptides	histone deacetylase	null	9734	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Synthesis and histone_deacetylase inhibitory activity of cyclic_tetrapeptides containing a retrohydroxamate as zinc ligand .
9873607	0	cyclic_urea	36,47	factor_Xa	62,71	cyclic urea	factor Xa	null	2159	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|nmod|END_ENTITY	The de novo design and synthesis of cyclic_urea inhibitors of factor_Xa : initial SAR studies .
19423310	0	cyclitols	33,42	NF-kappaB	0,9	cyclitols	NF-kappaB	MESH:D054812	4790	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	NF-kappaB inhibitory activity of cyclitols isolated from Hancornia speciosa .
17517511	0	cycloalkenecarboxylic_acid_methyl_esters	66,106	dopamine_transporter	135,155	cycloalkenecarboxylic acid methyl esters	dopamine transporter	null	6531	Chemical	Gene	studies|nmod|START_ENTITY studies|nmod|END_ENTITY	QSAR studies and pharmacophore identification for arylsubstituted cycloalkenecarboxylic_acid_methyl_esters with affinity for the human dopamine_transporter .
2914890	0	cycloalkylamines	13,29	cytochrome_P-450	33,49	cycloalkylamines	cytochrome P-450	null	4051	Chemical	Gene	Oxidation|nmod|START_ENTITY Oxidation|nmod|END_ENTITY	Oxidation of cycloalkylamines by cytochrome_P-450 .
7740081	0	cyclobutane_pyrimidine_dimer	13,41	photolyase	42,52	cyclobutane pyrimidine dimer	photolyase	null	100049426(Tax:8090)	Chemical	Gene	Induction|nmod|START_ENTITY END_ENTITY|nsubj|Induction	Induction of cyclobutane_pyrimidine_dimer photolyase in cultured fish cells by fluorescent light and oxygen stress .
11866513	0	cyclobutane_pyrimidine_dimers	141,170	MFA2	178,182	cyclobutane pyrimidine dimers	MFA2	MESH:D011740	855577(Tax:4932)	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	The Saccharomyces_cerevisiae histone acetyltransferase Gcn5 has a role in the photoreactivation and nucleotide excision repair of UV-induced cyclobutane_pyrimidine_dimers in the MFA2 gene .
9653449	0	cyclobutane_pyrimidine_dimers	10,39	MGMT	101,105	cyclobutane pyrimidine dimers	MGMT	MESH:D011740	4255	Chemical	Gene	START_ENTITY|nmod|gene gene|nmod|END_ENTITY	Repair of cyclobutane_pyrimidine_dimers in the O6-methylguanine-DNA_methyltransferase -LRB- MGMT -RRB- gene of MGMT proficient and deficient human cell lines and comparison with the repair of other genes and a repressed X-chromosomal locus .
9653449	0	cyclobutane_pyrimidine_dimers	10,39	O6-methylguanine-DNA_methyltransferase	47,85	cyclobutane pyrimidine dimers	O6-methylguanine-DNA methyltransferase	MESH:D011740	4255	Chemical	Gene	START_ENTITY|nmod|gene gene|amod|END_ENTITY	Repair of cyclobutane_pyrimidine_dimers in the O6-methylguanine-DNA_methyltransferase -LRB- MGMT -RRB- gene of MGMT proficient and deficient human cell lines and comparison with the repair of other genes and a repressed X-chromosomal locus .
1577723	0	cyclobutane_pyrimidine_dimers	63,92	adenosine_deaminase	106,125	cyclobutane pyrimidine dimers	adenosine deaminase	MESH:D011740	100	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Transcription affects the rate but not the extent of repair of cyclobutane_pyrimidine_dimers in the human adenosine_deaminase gene .
7970701	0	cyclobutane_pyrimidine_dimers	27,56	p53	66,69	cyclobutane pyrimidine dimers	p53	MESH:D011740	22060(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Strand-specific removal of cyclobutane_pyrimidine_dimers from the p53 gene in the epidermis of UVB-irradiated hairless mice .
1655791	0	cyclobutane_pyrimidine_dimers	65,94	topoisomerase_II	25,41	cyclobutane pyrimidine dimers	topoisomerase II	MESH:D011740	35225(Tax:7227)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of eukaryotic topoisomerase_II by ultraviolet-induced cyclobutane_pyrimidine_dimers .
16401581	0	cyclodextrins	53,66	insulin	40,47	cyclodextrins	insulin	MESH:D003505	280829(Tax:9913)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of coencapsulation of bovine insulin with cyclodextrins in ethylcellulose microcapsules .
7249350	0	cyclofenil	57,67	prolactin	6,15	cyclofenil	prolactin	MESH:D003506	5617	Chemical	Gene	Serum|nmod|START_ENTITY Serum|dobj|levels levels|compound|END_ENTITY	Serum prolactin levels during inhibition of lactation by cyclofenil .
21554155	0	cyclohexane	33,44	CCR2	60,64	cyclohexane	CCR2	MESH:C506365	729230	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|nmod|END_ENTITY	4-Azetidinyl-1-heteroatom linked cyclohexane antagonists of CCR2 : patent evaluation .
5119767	0	cyclohexanol	18,30	CL1	53,56	cyclohexanol	CL1	MESH:D003511	22859	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|nmod|END_ENTITY	The metabolism of cyclohexanol by Nocardia globerula CL1 .
22385473	0	cyclohexene_oxide	66,83	III	121,124	cyclohexene oxide	III	MESH:C007193	4514	Chemical	Gene	complexes|amod|START_ENTITY complexes|appos|END_ENTITY	Enhanced asymmetric induction for the copolymerization of CO2 and cyclohexene_oxide with unsymmetric enantiopure salenCo -LRB- III -RRB- complexes : synthesis of crystalline CO2-based polycarbonate .
9767525	5	cycloheximide	827,840	CHX	842,845	cycloheximide	TNF	MESH:D003513	7124	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|appos|END_ENTITY	The effect of another protein synthesis inhibitor , cycloheximide -LRB- CHX -RRB- , on these parameters was also evaluated .
9414112	0	cycloheximide	32,45	COX-2	18,23	cycloheximide	COX-2	MESH:D003513	5743	Chemical	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	Superinduction of COX-2 mRNA by cycloheximide and interleukin-1beta involves increased transcription and correlates with increased NF-kappaB and JNK activation .
10479292	0	cycloheximide	38,51	FKBP12	91,97	cycloheximide	FKBP12	MESH:D003513	2285	Chemical	Gene	derivatives|amod|START_ENTITY evaluation|nmod|derivatives evaluation|nmod|inhibitors inhibitors|nmod|END_ENTITY	Synthesis and cytotoxic evaluation of cycloheximide derivatives as potential inhibitors of FKBP12 with neuroregenerative properties .
9253159	0	cycloheximide	58,71	Fas_antigen	19,30	cycloheximide	Fas antigen	MESH:D003513	14102(Tax:10090)	Chemical	Gene	induction|nmod|START_ENTITY induction|nmod|expression expression|compound|END_ENTITY	Rapid induction of Fas_antigen mRNA expression in vivo by cycloheximide .
15987266	0	cycloheximide	110,123	Growth-associated_protein_43	0,28	cycloheximide	Growth-associated protein 43	MESH:D003513	29423(Tax:10116)	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|expression expression|amod|END_ENTITY	Growth-associated_protein_43 expression in hippocampal molecular layer of chronic epileptic rats treated with cycloheximide .
1122557	0	cycloheximide	11,24	MPF	91,94	cycloheximide	MPF	MESH:D003513	380246(Tax:8355)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of cycloheximide on the `` autocatalytic '' nature of the maturation_promoting_factor -LRB- MPF -RRB- in oocytes of Xenopus_laevis .
11216854	0	cycloheximide	48,61	P-glycoprotein	13,27	cycloheximide	P-glycoprotein	MESH:D003513	5243	Chemical	Gene	transcripts|nmod|START_ENTITY transcripts|amod|END_ENTITY	Induction of P-glycoprotein mRNA transcripts by cycloheximide in animal tissues : evidence that class I Pgp is transcriptionally regulated whereas class II Pgp is post-transcriptionally regulated .
15684068	6	cycloheximide	788,801	SHM	905,908	cycloheximide	AID	MESH:D003513	57379	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|nmod|END_ENTITY	In addition , we found that cycloheximide but not Ugi -LRB- the specific inhibitor of UNG -RRB- inhibited AID-dependent DNA cleavage in the Ig gene during SHM , by using histone H2AX focus formation as a marker of DNA cleavage .
8114707	0	cycloheximide	56,69	apolipoprotein_II	16,33	cycloheximide	apolipoprotein II	MESH:D003513	396476(Tax:9031)	Chemical	Gene	transcription|nmod|START_ENTITY transcription|amod|END_ENTITY	Reactivation of apolipoprotein_II gene transcription by cycloheximide reveals two steps in the deactivation of estrogen receptor-mediated transcription .
12557470	0	cycloheximide	14,27	butyrylcholinesterase	31,52	cycloheximide	butyrylcholinesterase	MESH:D003513	65036(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|amod|END_ENTITY	The effect of cycloheximide on butyrylcholinesterase activity in vivo .
510456	0	cycloheximide	13,26	delta-aminolevulinic_acid_synthetase	49,85	cycloheximide	delta-aminolevulinic acid synthetase	MESH:D003513	65155(Tax:10116)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of cycloheximide on normal and induced delta-aminolevulinic_acid_synthetase -LRB- aminoketone synthesis -RRB- of rat liver in vivo and in vitro .
4990844	0	cycloheximide	10,23	diamine_oxidase	41,56	cycloheximide	diamine oxidase	MESH:D003513	26	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of cycloheximide on production of diamine_oxidase by the human placenta .
10100886	0	cycloheximide	10,23	gonadotrophin-releasing_hormone	47,78	cycloheximide	gonadotrophin-releasing hormone	MESH:D003513	2796	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of cycloheximide and tunicamycin on the gonadotrophin-releasing_hormone stimulated distal glycosylation of luteinizing hormone by rat pituitary cells .
8955877	0	cycloheximide	10,23	iNOS	59,63	cycloheximide	iNOS	MESH:D003513	18126(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effect of cycloheximide on the expression of LPS-inducible iNOS , IFN-beta , and IRF-1 genes in J774 macrophages .
2474468	0	cycloheximide	11,24	insulin-like_growth_factor-I	48,76	cycloheximide	insulin-like growth factor-I	MESH:D003513	24482(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|mRNA mRNA|compound|END_ENTITY	Effects of cycloheximide on hepatic and uterine insulin-like_growth_factor-I mRNA .
2318820	0	cycloheximide	69,82	parathyroid_hormone-related_peptide	14,49	cycloheximide	parathyroid hormone-related peptide	MESH:D003513	5744	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of parathyroid_hormone-related_peptide gene expression by cycloheximide .
9221929	0	cycloheximide	14,27	proenkephalin	49,62	cycloheximide	proenkephalin	MESH:D003513	29237(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	The effect of cycloheximide on the regulation of proenkephalin and prodynorphin gene expressions induced by kainic_acid in rat hippocampus .
7662587	0	cycloheximide	76,89	sex_hormone-binding_globulin	14,42	cycloheximide	sex hormone-binding globulin	MESH:D003513	6462	Chemical	Gene	secretion|nmod|START_ENTITY secretion|amod|END_ENTITY	Regulation of sex_hormone-binding_globulin secretion and gene expression by cycloheximide in vitro .
22061641	0	cyclohexylamide	23,38	CCR2	39,43	cyclohexylamide	CCR2	null	12772(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|antagonists antagonists|nummod|END_ENTITY	The discovery of novel cyclohexylamide CCR2 antagonists .
9792908	0	cyclolinopeptide_A	77,95	cyclophilin_A	36,49	cyclolinopeptide A	cyclophilin A	MESH:C055018	281418(Tax:9913)	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Specific interaction between bovine cyclophilin_A and synthetic analogues of cyclolinopeptide_A .
20814245	0	cyclopamine	47,58	Gli3	0,4	cyclopamine	Gli3	MESH:C000541	2737	Chemical	Gene	mediates|advcl|START_ENTITY mediates|nsubj|END_ENTITY	Gli3 mediates cell survival and sensitivity to cyclopamine in pancreatic_cancer .
26773496	0	cyclopamine	101,112	MITF	13,17	cyclopamine	MITF	MESH:C000541	4286	Chemical	Gene	expression|nmod|START_ENTITY expression|nsubj|Induction Induction|nmod|END_ENTITY	Induction of MITF expression in human cholangiocarcinoma cells and hepatocellular_carcinoma cells by cyclopamine , an inhibitor of the Hedgehog signaling .
17602833	0	cyclopamine	31,42	p27	63,66	cyclopamine	p27	MESH:C000541	10671	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|nmod|END_ENTITY	The hedgehog pathway inhibitor cyclopamine increases levels of p27 , and decreases both expression of IGF-II and activation of Akt in PC-3_prostate_cancer cells .
12060710	0	cyclopamine	136,147	sonic_hedgehog	96,110	cyclopamine	sonic hedgehog	MESH:C000541	30269(Tax:7955)	Chemical	Gene	altered|xcomp|START_ENTITY altered|nmod|expression expression|nmod|END_ENTITY	Bone patterning is altered in the regenerating zebrafish caudal fin after ectopic expression of sonic_hedgehog and bmp2b or exposure to cyclopamine .
9716521	0	cyclopamine	34,45	sonic_hedgehog	55,69	cyclopamine	sonic hedgehog	MESH:C000541	395615(Tax:9031)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	The teratogenic Veratrum alkaloid cyclopamine inhibits sonic_hedgehog signal transduction .
19237229	0	cyclopentane	4,16	AKR1C1	75,81	cyclopentane	AKR1C1	MESH:D003517	1645	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	New cyclopentane derivatives as inhibitors of steroid metabolizing enzymes AKR1C1 and AKR1C3 .
11897581	0	cyclopentane	23,35	neuraminidase	36,49	cyclopentane	neuraminidase	MESH:D003517	4758	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Oral administration of cyclopentane neuraminidase inhibitors protects ferrets against influenza_virus_infection .
8663202	0	cyclopentenone	37,51	BiP	14,17	cyclopentenone	BiP	MESH:C013905	2662	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Regulation of BiP gene expression by cyclopentenone prostaglandins through unfolded protein response element .
25754985	0	cyclopentenone_prostaglandins	50,79	Protein_disulfide_isomerase	0,27	cyclopentenone prostaglandins	Protein disulfide isomerase	null	64714	Chemical	Gene	target|nmod|START_ENTITY END_ENTITY|nmod|target	Protein_disulfide_isomerase as a novel target for cyclopentenone_prostaglandins : implications for hypoxic_ischemic_injury .
15659834	0	cyclopentenone_prostaglandins	11,40	heme_oxygenase-1	62,78	cyclopentenone prostaglandins	heme oxygenase-1	null	3162	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effects of cyclopentenone_prostaglandins on the expression of heme_oxygenase-1 in MCF-7 cells .
10936191	0	cyclopentenone_prostaglandins	52,81	nerve_growth_factor	127,146	cyclopentenone prostaglandins	nerve growth factor	null	310738(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activities activities|nmod|END_ENTITY	Facilitatory roles of novel compounds designed from cyclopentenone_prostaglandins on neurite outgrowth-promoting activities of nerve_growth_factor .
23748434	0	cyclopentyladenosine	136,156	GluN2A	62,68	cyclopentyladenosine	GluN2A	null	24409(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY expression|dep|role expression|amod|END_ENTITY	3-Mercaptopropionic_acid-induced repetitive_seizures increase GluN2A expression in rat hippocampus : a potential neuroprotective role of cyclopentyladenosine .
24507922	0	cyclopentylamine	15,31	NK1_receptor	57,69	cyclopentylamine	NK1 receptor	MESH:C016329	6869	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|amod|END_ENTITY	Discovery of a cyclopentylamine as an orally active dual NK1_receptor antagonist-serotonin reuptake transporter inhibitor .
24028535	0	cyclopentylamines	96,113	chemokine_receptor_2	117,137	cyclopentylamines	chemokine receptor 2	null	729230	Chemical	Gene	START_ENTITY|nmod|antagonists antagonists|amod|END_ENTITY	Structure-kinetic relationships -- an overlooked parameter in hit-to-lead optimization : a case of cyclopentylamines as chemokine_receptor_2 antagonists .
23391375	0	cyclopeptides	19,32	insulin	78,85	cyclopeptides	insulin	null	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of cationic cyclopeptides on transdermal and transmembrane delivery of insulin .
19122326	0	cyclophane	46,56	N-methyl-D-aspartate_receptor	63,92	cyclophane	N-methyl-D-aspartate receptor	null	397953(Tax:8355)	Chemical	Gene	START_ENTITY|nmod|antagonist antagonist|amod|END_ENTITY	Synthesis of a novel water-soluble cleft-type cyclophane as an N-methyl-D-aspartate_receptor antagonist .
1386724	0	cyclophellitol	72,86	glucocerebrosidase	14,32	cyclophellitol	glucocerebrosidase	MESH:C063285	14466(Tax:10090)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of glucocerebrosidase and induction of neural_abnormality by cyclophellitol in mice .
20338811	0	cyclophosphamide	51,67	CD4	0,3	cyclophosphamide	CD4	MESH:D003520	920	Chemical	Gene	depletion|nmod|START_ENTITY depletion|compound|END_ENTITY	CD4 + FOXP3 + regulatory T cell depletion by low-dose cyclophosphamide prevents recurrence in patients with large condylomata acuminata after laser therapy .
12872149	0	cyclophosphamide	18,34	CIB	72,75	cyclophosphamide	CIB	MESH:D003520	10519	Chemical	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Phase II study of cyclophosphamide , interferon-alpha and betamethasone -LRB- CIB -RRB- as induction therapy for patients 60-75 years of age with multiple_myeloma stages II and III .
12629583	0	cyclophosphamide	36,52	CYP2B6	26,32	cyclophosphamide	CYP2B6	MESH:D003520	1555	Chemical	Gene	bioactivation|amod|START_ENTITY Role|nmod|bioactivation Role|nmod|END_ENTITY	Role of polymorphic human CYP2B6 in cyclophosphamide bioactivation .
17502835	0	cyclophosphamide	80,96	CYP2B6	25,31	cyclophosphamide	CYP2B6	MESH:D003520	1555	Chemical	Gene	pharmacokinetics/pharmacodynamics|nmod|START_ENTITY affect|dobj|pharmacokinetics/pharmacodynamics affect|nsubj|polymorphisms polymorphisms|nmod|END_ENTITY	Genetic polymorphisms of CYP2B6 affect the pharmacokinetics/pharmacodynamics of cyclophosphamide in Japanese cancer patients .
17875191	0	cyclophosphamide	35,51	CYP2B6	67,73	cyclophosphamide	CYP2B6	MESH:D003520	1555	Chemical	Gene	START_ENTITY|nmod|relation relation|nmod|END_ENTITY	Serious haematological toxicity of cyclophosphamide in relation to CYP2B6 , GSTA1 and GSTP1 polymorphisms .
18212249	0	cyclophosphamide	15,31	CYP2B6	46,52	cyclophosphamide	CYP2B6	MESH:D003520	1555	Chemical	Gene	Improvement|nmod|START_ENTITY activation|nsubj|Improvement activation|nmod|mutants mutants|nummod|END_ENTITY	Improvement of cyclophosphamide activation by CYP2B6 mutants : from in silico to ex vivo .
18496131	0	cyclophosphamide	160,176	CYP2B6	57,63	cyclophosphamide	CYP2B6	MESH:D003520	1555	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY Influence|nmod|pharmacokinetics Influence|dep|END_ENTITY	Influence of polymorphisms of drug metabolizing enzymes -LRB- CYP2B6 , CYP2C9 , CYP2C19 , CYP3A4 , CYP3A5 , GSTA1 , GSTP1 , ALDH1A1 and ALDH3A1 -RRB- on the pharmacokinetics of cyclophosphamide and 4-hydroxycyclophosphamide .
21442647	0	cyclophosphamide	80,96	CYP2B6	40,46	cyclophosphamide	CYP2B6	MESH:D003520	1555	Chemical	Gene	importance|acl|START_ENTITY importance|nmod|assignment assignment|nmod|variants variants|nummod|END_ENTITY	The importance of correct assignment of CYP2B6 genetic variants with respect to cyclophosphamide metabolizer status .
21821736	0	cyclophosphamide	57,73	CYP2B6	98,104	cyclophosphamide	CYP2B6	MESH:D003520	1555	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|acl|caused caused|nmod|variant variant|nummod|END_ENTITY	Q172H replacement overcomes effects on the metabolism of cyclophosphamide and efavirenz caused by CYP2B6 variant with Arg262 .
24128861	0	cyclophosphamide	80,96	CYP2B6	0,6	cyclophosphamide	CYP2B6	MESH:D003520	1555	Chemical	Gene	fludarabine|dobj|START_ENTITY determinant|acl|fludarabine determinant|nsubj|* *|compound|END_ENTITY	CYP2B6 * 6 is an independent determinant of inferior response to fludarabine plus cyclophosphamide in chronic_lymphocytic_leukemia .
25428516	0	cyclophosphamide	62,78	CYP2B6	11,17	cyclophosphamide	CYP2B6	MESH:D003520	1555	Chemical	Gene	combination|amod|START_ENTITY receiving|dobj|combination Effects|acl|receiving Effects|nmod|polymorphisms polymorphisms|nummod|END_ENTITY	Effects of CYP2B6 genetic polymorphisms in patients receiving cyclophosphamide combination chemotherapy for breast_cancer .
11965495	0	cyclophosphamide	88,104	Cyclin_dependent_kinase_5	0,25	cyclophosphamide	Cyclin dependent kinase 5	MESH:D003520	12568(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|END_ENTITY	Cyclin_dependent_kinase_5 and its interacting proteins in cell death induced in vivo by cyclophosphamide in developing mouse embryos .
18481113	0	cyclophosphamide	29,45	Cyclosporin_A	0,13	cyclophosphamide	Cyclosporin A	MESH:D003520	1161	Chemical	Gene	superior|xcomp|START_ENTITY superior|nsubj|END_ENTITY	Cyclosporin_A is superior to cyclophosphamide in children with steroid-resistant nephrotic_syndrome-a randomized controlled multicentre trial by the Arbeitsgemeinschaft f r P diatrische Nephrologie .
2741218	0	cyclophosphamide	15,31	FAC	119,122	cyclophosphamide	FAC	MESH:D003520	2176	Chemical	Gene	Combination|nmod|START_ENTITY Combination|appos|END_ENTITY	Combination of cyclophosphamide , adriamycin and platinum -LRB- CAP -RRB- versus 5-fluorouracil , adriamycin and cyclophosphamide -LRB- FAC -RRB- as primary treatment in metastatic breast_cancer : results of a prospective randomized study .
20338811	0	cyclophosphamide	51,67	FOXP3	4,9	cyclophosphamide	FOXP3	MESH:D003520	50943	Chemical	Gene	depletion|nmod|START_ENTITY depletion|compound|END_ENTITY	CD4 + FOXP3 + regulatory T cell depletion by low-dose cyclophosphamide prevents recurrence in patients with large condylomata acuminata after laser therapy .
16110137	0	cyclophosphamide	28,44	GM-CSF	128,134	cyclophosphamide	GM-CSF	MESH:D003520	1437	Chemical	Gene	trial|nmod|START_ENTITY trial|appos|END_ENTITY	Phase I trial of infusional cyclophosphamide , doxorubicin , and etoposide plus granulocyte-macrophage_colony_stimulating_factor -LRB- GM-CSF -RRB- in non-Hodgkin 's _ lymphoma .
11583189	0	cyclophosphamide	165,181	HER-2_and_topo-isomerase_IIalpha	0,32	cyclophosphamide	HER-2 and topo-isomerase IIalpha	MESH:D003520	2064	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|END_ENTITY	HER-2_and_topo-isomerase_IIalpha as predictive markers in a population of node-positive_breast_cancer patients randomly treated with adjuvant CMF or epirubicin plus cyclophosphamide .
1991694	0	cyclophosphamide	45,61	Interleukin-1	0,13	cyclophosphamide	Interleukin-1	MESH:D003520	3552	Chemical	Gene	irradiation|amod|START_ENTITY modification|nmod|irradiation modification|amod|END_ENTITY	Interleukin-1 modification of the effects of cyclophosphamide and fractionated irradiation .
7860617	0	cyclophosphamide	80,96	Interleukin-2	0,13	cyclophosphamide	Interleukin-2	MESH:D003520	16183(Tax:10090)	Chemical	Gene	pretreatment|amod|START_ENTITY effect|nmod|pretreatment potentiates|dobj|effect potentiates|nsubj|therapy therapy|amod|END_ENTITY	Interleukin-2 gene therapy of residual EL-4 leukaemia potentiates the effect of cyclophosphamide pretreatment .
8318754	0	cyclophosphamide	53,69	LHRH	77,81	cyclophosphamide	LHRH	MESH:D003520	25194(Tax:10116)	Chemical	Gene	agonist|amod|START_ENTITY agonist|compound|END_ENTITY	Reproductive performance of female rats treated with cyclophosphamide and/or LHRH agonist .
11893254	0	cyclophosphamide	70,86	NF-kappa_B	0,10	cyclophosphamide	NF-kappa B	MESH:D003520	4790	Chemical	Gene	START_ENTITY|nsubj|activity activity|amod|END_ENTITY	NF-kappa_B DNA-binding activity in embryos responding to a teratogen , cyclophosphamide .
9714064	0	cyclophosphamide	67,83	O6-methylguanine-DNA_methyltransferase	0,38	cyclophosphamide	O6-methylguanine-DNA methyltransferase	MESH:D003520	4255	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	O6-methylguanine-DNA_methyltransferase activity and sensitivity to cyclophosphamide and cisplatin in human lung_tumor xenografts .
19266253	0	cyclophosphamide	126,142	PARP	48,52	cyclophosphamide	PARP	MESH:D003520	25591(Tax:10116)	Chemical	Gene	dose|nmod|START_ENTITY END_ENTITY|nmod|dose	Nitrosative stress , protein tyrosine nitration , PARP activation and NAD depletion in the kidneys of rats after single dose of cyclophosphamide .
23228633	0	cyclophosphamide	112,128	Thrombospondin-1_and_pigment_epithelium-derived_factor	0,54	cyclophosphamide	Thrombospondin-1 and pigment epithelium-derived factor	MESH:D003520	7057;57104	Chemical	Gene	enhance|nmod|START_ENTITY enhance|nsubj|END_ENTITY	Thrombospondin-1_and_pigment_epithelium-derived_factor enhance responsiveness of KM12 colon_tumor to metronomic cyclophosphamide but have disparate effects on tumor metastasis .
20652634	0	cyclophosphamide	89,105	acetylcholinesterase	54,74	cyclophosphamide	acetylcholinesterase	MESH:D003520	83817(Tax:10116)	Chemical	Gene	analyse|nmod|START_ENTITY analyse|dobj|data data|nmod|inhibition inhibition|compound|END_ENTITY	Multiple approaches to analyse the data for rat brain acetylcholinesterase inhibition by cyclophosphamide .
22229321	0	cyclophosphamide	50,66	acetylcholinesterase	15,35	cyclophosphamide	acetylcholinesterase	MESH:D003520	43	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Human platelet acetylcholinesterase inhibition by cyclophosphamide : a combined experimental and computational approach .
7863507	0	cyclophosphamide	44,60	acetylcholinesterase	20,40	cyclophosphamide	acetylcholinesterase	MESH:D003520	43	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of human acetylcholinesterase by cyclophosphamide .
8430432	0	cyclophosphamide	28,44	acetylcholinesterase	48,68	cyclophosphamide	acetylcholinesterase	MESH:D003520	396388(Tax:9031)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|amod|END_ENTITY	The toxicological effect of cyclophosphamide on acetylcholinesterase activity .
9352076	0	cyclophosphamide	106,122	acetylcholinesterase	71,91	cyclophosphamide	acetylcholinesterase	MESH:D003520	396388(Tax:9031)	Chemical	Gene	parameters|nmod|START_ENTITY parameters|nmod|inhibition inhibition|amod|END_ENTITY	Dual temperature model for the estimation of energetics parameters for acetylcholinesterase inhibition by cyclophosphamide .
11468938	0	cyclophosphamide	94,110	cytochrome_P450	48,63	cyclophosphamide	cytochrome P450	MESH:D003520	4051	Chemical	Gene	interaction|nmod|START_ENTITY interaction|amod|END_ENTITY	A mechanism-based pharmacokinetic model for the cytochrome_P450 drug-drug interaction between cyclophosphamide and thioTEPA and the autoinduction of cyclophosphamide .
1632821	0	cyclophosphamide	40,56	cytochrome_P450	64,79	cyclophosphamide	cytochrome P450	MESH:D003520	25251(Tax:10116)	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|END_ENTITY	Investigation of the mechanism by which cyclophosphamide alters cytochrome_P450 in male rats .
6794303	0	cyclophosphamide	106,122	erythropoietin	10,24	cyclophosphamide	erythropoietin	MESH:D003520	13856(Tax:10090)	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|Effect Effect|nmod|END_ENTITY	Effect of erythropoietin on erythropoietin-responsive cell regeneration in polycythemic mice treated with cyclophosphamide .
16733672	0	cyclophosphamide	9,25	galectin-1	36,46	cyclophosphamide	galectin-1	MESH:D003520	56646(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	Low-dose cyclophosphamide modulates galectin-1 expression and function in an experimental rat_lymphoma model .
8636780	0	cyclophosphamide	130,146	granulocyte-macrophage_colony-stimulating_factor	23,71	cyclophosphamide	granulocyte-macrophage colony-stimulating factor	MESH:D003520	1437	Chemical	Gene	therapy|compound|START_ENTITY effects|nmod|therapy effects|nmod|END_ENTITY	Comparative effects of granulocyte-macrophage_colony-stimulating_factor and granulocyte_colony-stimulating_factor after high-dose cyclophosphamide cancer therapy .
12625410	0	cyclophosphamide	63,79	growth_hormone	11,25	cyclophosphamide	growth hormone	MESH:D003520	81668(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Effects Effects|nmod|END_ENTITY	Effects of growth_hormone on testicular_dysfunction induced by cyclophosphamide -LRB- CP -RRB- in GH-deficient rats .
8176939	0	cyclophosphamide	78,94	interleukin-1	48,61	cyclophosphamide	interleukin-1	MESH:D003520	111343(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The synergistic antitumor effect of recombinant interleukin-1 and low-dose of cyclophosphamide in tumor-bearing mice .
1735618	0	cyclophosphamide	100,116	interleukin-2	81,94	cyclophosphamide	interleukin-2	MESH:D003520	16183(Tax:10090)	Chemical	Gene	potentiates|nmod|START_ENTITY potentiates|dobj|activity activity|nmod|END_ENTITY	Combination therapy with thymosin alpha 1 potentiates the anti-tumor activity of interleukin-2 with cyclophosphamide in the treatment of the Lewis_lung_carcinoma in mice .
18256325	0	cyclophosphamide	35,51	interleukin-2	153,166	cyclophosphamide	interleukin-2	MESH:D003520	3558	Chemical	Gene	transplantation|amod|START_ENTITY irradiation|appos|transplantation followed|nsubj|irradiation followed|nmod|END_ENTITY	Total body irradiation , etoposide , cyclophosphamide , and autologous peripheral blood stem-cell transplantation followed by randomization to therapy with interleukin-2 versus observation for patients with non-Hodgkin_lymphoma : results of a phase 3 randomized trial by the Southwest Oncology Group -LRB- SWOG 9438 -RRB- .
2598180	0	cyclophosphamide	93,109	interleukin-2	42,55	cyclophosphamide	interleukin-2	MESH:D003520	3558	Chemical	Gene	cells|amod|START_ENTITY efficacy|nmod|cells efficacy|nmod|END_ENTITY	Therapeutic efficacy of human recombinant interleukin-2 -LRB- TGP-3 -RRB- alone or in combination with cyclophosphamide and immunocompetent cells in allogeneic , semi-syngeneic , _ and_syngeneic_murine_tumors .
2670215	0	cyclophosphamide	50,66	interleukin-2	23,36	cyclophosphamide	interleukin-2	MESH:D003520	3558	Chemical	Gene	START_ENTITY|nsubj|trial trial|nmod|END_ENTITY	A multicenter trial of interleukin-2 and low-dose cyclophosphamide in highly chemotherapy-resistant malignancies .
7600560	0	cyclophosphamide	33,49	interleukin-2	16,29	cyclophosphamide	interleukin-2	MESH:D003520	16183(Tax:10090)	Chemical	Gene	therapy|amod|START_ENTITY END_ENTITY|nmod|therapy	The addition of interleukin-2 to cyclophosphamide therapy can facilitate tumor growth of B16_melanoma .
8264254	0	cyclophosphamide	9,25	interleukin-2	72,85	cyclophosphamide	interleukin-2	MESH:D003520	3558	Chemical	Gene	infusions|amod|START_ENTITY infusions|nmod|END_ENTITY	Low dose cyclophosphamide , alpha-interferon and continuous infusions of interleukin-2 in advanced renal_cell_carcinoma .
9792934	0	cyclophosphamide	48,64	interleukin-2	11,24	cyclophosphamide	interleukin-2	MESH:D003520	3558	Chemical	Gene	Continuous|advcl|START_ENTITY Continuous|dobj|infusion infusion|compound|END_ENTITY	Continuous interleukin-2 infusion combined with cyclophosphamide - based combination chemotherapy in the treatment of hemato-oncological_malignancies .
18997060	0	cyclophosphamide	51,67	lpr	144,147	cyclophosphamide	lpr	MESH:D003520	14102(Tax:10090)	Chemical	Gene	mice|amod|START_ENTITY mice|appos|END_ENTITY	Anti-Ccl2 Spiegelmer permits 75 % dose reduction of cyclophosphamide to control diffuse_proliferative_lupus_nephritis and pneumonitis in MRL-Fas -LRB- lpr -RRB- mice .
23053256	0	cyclophosphamide	57,73	mTOR	21,25	cyclophosphamide	mTOR	MESH:D003520	21977(Tax:10090)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|activity activity|nmod|END_ENTITY	Clinical activity of mTOR inhibition in combination with cyclophosphamide in the treatment of recurrent unresectable chondrosarcomas .
1615753	0	cyclophosphamide	90,106	tumor_necrosis_factor_alpha	42,69	cyclophosphamide	tumor necrosis factor alpha	MESH:D003520	7124	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Antileukemic effects of recombinant human tumor_necrosis_factor_alpha -LRB- rh-TNF alpha -RRB- with cyclophosphamide or methotrexate on leukemia L1210_and_leukemia_P388 in mice .
7627991	0	cyclophosphamide	40,56	tumor_necrosis_factor_alpha	62,89	cyclophosphamide	tumor necrosis factor alpha	MESH:D003520	21926(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|treatment treatment|compound|END_ENTITY	Protective specific immunity induced by cyclophosphamide plus tumor_necrosis_factor_alpha combination treatment of EL4-lymphoma-bearing C57BL/6 mice .
1388315	0	cyclopiazonic_acid	11,29	ATPase	56,62	cyclopiazonic acid	ATPase	MESH:C000543	1769	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|inhibitor inhibitor|nmod|END_ENTITY	Effects of cyclopiazonic_acid , an inhibitor of the Ca + + ATPase of sarcoplasmic reticulum , on Ca + + transport , contraction and relaxation in cardiac muscle .
17827742	0	cycloprodigiosin_hydrochloride	32,62	AP-1	15,19	cycloprodigiosin hydrochloride	AP-1	MESH:C108328	3725	Chemical	Gene	Suppression|nmod|START_ENTITY Suppression|nmod|activity activity|compound|END_ENTITY	Suppression of AP-1 activity by cycloprodigiosin_hydrochloride .
20051531	0	cyclosarin	65,75	carboxylesterase_1	6,24	cyclosarin	carboxylesterase 1	MESH:C053914	1066	Chemical	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Human carboxylesterase_1 stereoselectively binds the nerve agent cyclosarin and spontaneously hydrolyzes the nerve agent sarin .
11271305	0	cyclosporin	46,57	IL-6	92,96	cyclosporin	IL-6	MESH:D016572	3569	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effect of immunosuppressive agents FK_506 and cyclosporin and steroids on the expression of IL-6 and its receptor by stimulated lymphocytes and monocytes .
15744817	0	cyclosporin	10,21	ZO-1	34,38	cyclosporin	ZO-1	MESH:D016572	292994(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Impact of cyclosporin on podocyte ZO-1 expression in puromycin_aminonucleoside nephrosis rats .
8188457	0	cyclosporin	10,21	cytidine_deaminase	41,59	cyclosporin	cytidine deaminase	MESH:D016572	978	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	Effect of cyclosporin on the activity of cytidine_deaminase and adenosine_deaminase in the serum and polymorphonuclear leukocytes of patients with rheumatoid_arthritis .
2371836	0	cyclosporin	11,22	cytochrome_P-450	63,79	cyclosporin	cytochrome P-450	MESH:D016572	4051	Chemical	Gene	vitro|dobj|START_ENTITY interaction|advcl|vitro interaction|advcl|END_ENTITY	`` In vitro '' cyclosporin and methylprednisolone interaction with cytochrome_P-450 .
2495007	0	cyclosporin	24,35	cytochrome_P-450	63,79	cyclosporin	cytochrome P-450	MESH:D016572	25251(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Differential effects of cyclosporin on hepatic and renal heme , cytochrome_P-450 and drug metabolism .
2688634	0	cyclosporin	97,108	cytochrome_P-450	69,85	cyclosporin	cytochrome P-450	MESH:D016572	4051	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|amod|END_ENTITY	Purification and characterization of an anticonvulsant-induced human cytochrome_P-450 catalysing cyclosporin metabolism .
7908376	0	cyclosporin	44,55	erythropoietin	13,27	cyclosporin	erythropoietin	MESH:D016572	2056	Chemical	Gene	Treatment|nmod|START_ENTITY Treatment|nmod|resistance resistance|compound|END_ENTITY	Treatment of erythropoietin resistance with cyclosporin .
8501418	0	cyclosporin	80,91	erythropoietin	14,28	cyclosporin	erythropoietin	MESH:D016572	2056	Chemical	Gene	treatment|compound|START_ENTITY associated|nmod|treatment anaemia|acl|associated responsible|nmod|anaemia responsible|nsubj|Deficiency Deficiency|nmod|END_ENTITY	Deficiency of erythropoietin is not responsible for the anaemia associated with cyclosporin treatment of insulin-dependent_diabetes_mellitus .
3299147	0	cyclosporin	12,23	gastrin	33,40	cyclosporin	gastrin	MESH:D016572	2520	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	-LSB- Effects of cyclosporin on blood gastrin after kidney transplant -RSB- .
2210078	0	cyclosporin	120,131	insulin	33,40	cyclosporin	insulin	MESH:D016572	3630	Chemical	Gene	treated|nmod|START_ENTITY duration|acl|treated duration|nmod|dependency dependency|compound|END_ENTITY	Limited duration of remission of insulin dependency in children with recent overt type_I_diabetes treated with low-dose cyclosporin .
2656339	0	cyclosporin	11,22	insulin	26,33	cyclosporin	insulin	MESH:D016572	483665(Tax:9615)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of cyclosporin on insulin and C-peptide secretion in healthy beagles .
1490303	0	cyclosporin	10,21	lipoprotein_lipase	32,50	cyclosporin	lipoprotein lipase	MESH:D016572	24539(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of cyclosporin on plasma lipoprotein_lipase activity in rats .
10444270	0	cyclosporin	145,156	monocyte_chemotactic_protein-1	84,114	cyclosporin	monocyte chemotactic protein-1	MESH:D016572	6347	Chemical	Gene	induced|nmod|START_ENTITY expression|acl|induced expression|amod|END_ENTITY	Low-density lipoproteins enhance transforming_growth_factor-beta_1 -LRB- TGF-beta_1 -RRB- and monocyte_chemotactic_protein-1 -LRB- MCP-1 -RRB- expression induced by cyclosporin in human mesangial cells .
17589148	0	cyclosporin	27,38	prolactin	14,23	cyclosporin	prolactin	MESH:D016572	5617	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of prolactin on cyclosporin in renal transplant patients .
8642062	0	cyclosporin	11,22	prolactin	36,45	cyclosporin	prolactin	MESH:D016572	24683(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY Effects|nmod|treatment Effects|nmod|pulsatility pulsatility|compound|END_ENTITY	Effects of cyclosporin treatment on prolactin pulsatility in chronic hyperprolactinemic male rats .
7953197	0	cyclosporin-A	11,24	protein_disulfide_isomerase	111,138	cyclosporin-A	protein disulfide isomerase	MESH:D016572	25506(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|acl|END_ENTITY	Effects of cyclosporin-A and D-penicillamine on the development of hepatitis and the production of antibody to protein_disulfide_isomerase in LEC rats .
11768242	0	cyclosporin_A	67,80	Angiotensin_II	0,14	cyclosporin A	Angiotensin II	MESH:D016572	24179(Tax:10116)	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|END_ENTITY	Angiotensin_II induced cardiac_hypertrophy in vivo is inhibited by cyclosporin_A in adult rats .
11813632	0	cyclosporin_A	105,118	CD4	25,28	cyclosporin A	CD4	MESH:D016572	920	Chemical	Gene	-RSB-|compound|START_ENTITY treated|nmod|-RSB- psoriasis|acl|treated patients|nmod|psoriasis skin|nmod|patients changes|nmod|skin changes|nmod|+ +|compound|END_ENTITY	-LSB- Quantitative changes in CD4 + and CD8 + T-lymphocytes in the skin of patients with psoriasis treated with cyclosporin_A -RSB- .
17164721	0	cyclosporin_A	27,40	CD4	56,59	cyclosporin A	CD4	MESH:D016572	12504(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|inhibition inhibition|nmod|CD25 CD25|compound|END_ENTITY	A potential side effect of cyclosporin_A : inhibition of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells in mice .
19779705	0	cyclosporin_A	5,18	CD4	28,31	cyclosporin A	CD4	MESH:D016572	920	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|activity activity|nsubj|T T|compound|END_ENTITY	Oral cyclosporin_A inhibits CD4 T cell P-glycoprotein activity in HIV-infected adults initiating treatment with nucleoside reverse transcriptase inhibitors .
7678228	0	cyclosporin_A	11,24	CD4	79,82	cyclosporin A	CD4	MESH:D016572	12504(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Effects of cyclosporin_A , FK_506 , and mycalamide_A on the activation of murine CD4 + T cells by the murine B7 antigen .
8828007	0	cyclosporin_A	88,101	CD4	51,54	cyclosporin A	CD4	MESH:D016572	12504(Tax:10090)	Chemical	Gene	presence|nmod|START_ENTITY thymocytes|nmod|presence thymocytes|nummod|+8 +8|compound|END_ENTITY	Cross-linking the TCR complex induces apoptosis in CD4 +8 + thymocytes in the presence of cyclosporin_A .
9184637	0	cyclosporin_A	79,92	CD4	56,59	cyclosporin A	CD4	MESH:D016572	920	Chemical	Gene	+|nmod|START_ENTITY +|nsubj|END_ENTITY	In vitro modulation of human , autoreactive MBP-specific CD4 + T-cell clones by cyclosporin_A .
3022056	4	cyclosporin_A	599,612	CsA	614,617	cyclosporin A	CsA	MESH:D016572	1161	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	In the present study , the effects of cyclosporin_A -LRB- CsA -RRB- were examined on growth , survival , and polyamine levels in H2T pancreatic_ductal_adenocarcinoma in vitro .
7590732	0	cyclosporin_A	74,87	Cyclophilin_A	0,13	cyclosporin A	Cyclophilin A	MESH:D016572	5478	Chemical	Gene	receptor|nmod|START_ENTITY END_ENTITY|appos|receptor	Cyclophilin_A , the major intracellular receptor for the immunosuppressant cyclosporin_A , maps to chromosome 7p11.2-p13 : four pseudogenes map to chromosomes 3 , 10 , 14 , and 18 .
12478844	0	cyclosporin_A	12,25	FasL	43,47	cyclosporin A	FasL	MESH:D016572	14103(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of cyclosporin_A on expression of FasL and Fas in the contralateral testis after the unilateral testis injured in KM mouse -RSB- .
7520875	0	cyclosporin_A	19,32	GRP78	0,5	cyclosporin A	GRP78	MESH:D016572	3309	Chemical	Gene	induction|nmod|START_ENTITY induction|nsubj|END_ENTITY	GRP78 induction by cyclosporin_A in human HeLa cells .
16643797	0	cyclosporin_A	11,24	IFN-gamma	46,55	cyclosporin A	IFN-gamma	MESH:D016572	15978(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	-LSB- Effect of cyclosporin_A on the production of IFN-gamma by murine splenocytes -RSB- .
7908481	0	cyclosporin_A	51,64	IFN-gamma	38,47	cyclosporin A	IFN-gamma	MESH:D016572	3458	Chemical	Gene	circulating|nmod|START_ENTITY circulating|dobj|END_ENTITY	An unexpected increase in circulating IFN-gamma by cyclosporin_A in atopic patients : a discrepancy between in vitro and in vivo events .
8335079	0	cyclosporin_A	19,32	Interleukin-8	0,13	cyclosporin A	Interleukin-8	MESH:D016572	3576	Chemical	Gene	protein|amod|START_ENTITY protein|nsubj|END_ENTITY	Interleukin-8 is a cyclosporin_A binding protein .
12751630	0	cyclosporin_A	30,43	P-glycoprotein	73,87	cyclosporin A	P-glycoprotein	MESH:D016572	5243	Chemical	Gene	permeability|nmod|START_ENTITY permeability|dep|influence influence|nmod|surfactants surfactants|nmod|efflux efflux|amod|END_ENTITY	Human jejunal permeability of cyclosporin_A : influence of surfactants on P-glycoprotein efflux in Caco-2 cells .
12817897	0	cyclosporin_A	36,49	P-glycoprotein	10,24	cyclosporin A	P-glycoprotein	MESH:D016572	287115(Tax:10116)	Chemical	Gene	modulator|appos|START_ENTITY modulator|amod|END_ENTITY	Effect of P-glycoprotein modulator , cyclosporin_A , on the gastrointestinal excretion of irinotecan and its metabolite SN-38 in rats .
15684491	0	cyclosporin_A	19,32	P-glycoprotein	107,121	cyclosporin A	P-glycoprotein	MESH:D016572	287115(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY substrates|nmod|effects substrates|nmod|P450 P450|amod|END_ENTITY	In vivo effects of cyclosporin_A and ketoconazole on the pharmacokinetics of representative substrates for P-glycoprotein and cytochrome P450 -LRB- CYP -RRB- 3A in rats .
15802827	0	cyclosporin_A	63,76	P-glycoprotein	16,30	cyclosporin A	P-glycoprotein	MESH:D016572	67078(Tax:10090)	Chemical	Gene	absorption|nmod|START_ENTITY role|nmod|absorption role|nmod|END_ENTITY	Limited role of P-glycoprotein in the intestinal absorption of cyclosporin_A .
16254147	0	cyclosporin_A	18,31	P-glycoprotein	50,64	cyclosporin A	P-glycoprotein	MESH:D016572	5243	Chemical	Gene	START_ENTITY|acl|modulate modulate|dobj|END_ENTITY	Randomized use of cyclosporin_A -LRB- CsA -RRB- to modulate P-glycoprotein in children with AML in remission : Pediatric Oncology Group Study 9421 .
16384676	0	cyclosporin_A	80,93	P-glycoprotein	28,42	cyclosporin A	P-glycoprotein	MESH:D016572	67078(Tax:10090)	Chemical	Gene	Contributions|nmod|START_ENTITY Contributions|nmod|END_ENTITY	Contributions of intestinal P-glycoprotein and CYP3A to oral bioavailability of cyclosporin_A in mice treated with or without dexamethasone .
16939683	0	cyclosporin_A	60,73	P-glycoprotein	32,46	cyclosporin A	P-glycoprotein	MESH:D016572	67078(Tax:10090)	Chemical	Gene	absorption|compound|START_ENTITY END_ENTITY|nmod|absorption	Site-dependent contributions of P-glycoprotein and CYP3A to cyclosporin_A absorption , and effect of dexamethasone in small intestine of mice .
17556798	0	cyclosporin_A	104,117	P-glycoprotein	20,34	cyclosporin A	P-glycoprotein	MESH:D016572	5243	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|Polymorphism Polymorphism|nmod|gene gene|amod|END_ENTITY	Polymorphism in the P-glycoprotein drug transporter MDR1 gene in renal transplant patients treated with cyclosporin_A in a Polish population .
7631829	0	cyclosporin_A	97,110	P-glycoprotein	40,54	cyclosporin A	P-glycoprotein	MESH:D016572	5243	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Differential interaction of human renal P-glycoprotein with various metabolites and analogues of cyclosporin_A .
7681059	0	cyclosporin_A	32,45	P-glycoprotein	6,20	cyclosporin A	P-glycoprotein	MESH:D016572	5243	Chemical	Gene	transports|dobj|START_ENTITY transports|nsubj|END_ENTITY	Human P-glycoprotein transports cyclosporin_A and FK506 .
8105783	0	cyclosporin_A	24,37	P-glycoprotein	97,111	cyclosporin A	P-glycoprotein	MESH:D016572	538173(Tax:9913)	Chemical	Gene	transport|nmod|START_ENTITY transport|nmod|barrier barrier|nmod|transporter transporter|appos|END_ENTITY	Restricted transport of cyclosporin_A across the blood-brain barrier by a multidrug transporter , P-glycoprotein .
8791998	0	cyclosporin_A	99,112	P-glycoprotein	13,27	cyclosporin A	P-glycoprotein	MESH:D016572	5243	Chemical	Gene	derivative|nmod|START_ENTITY NBDL-CsA|appos|derivative Detection|nmod|NBDL-CsA Detection|nmod|expression expression|amod|END_ENTITY	Detection of P-glycoprotein expression by tumoral cells with NBDL-CsA , a fluorescent derivative of cyclosporin_A .
8845477	0	cyclosporin_A	20,33	P-glycoprotein	37,51	cyclosporin A	P-glycoprotein	MESH:D016572	5243	Chemical	Gene	START_ENTITY|nmod|cells cells|amod|END_ENTITY	Decreased uptake of cyclosporin_A by P-glycoprotein -LRB- Pgp -RRB- expressing CEM_leukemic cells and restoration of normal retention by Pgp blockers .
9187258	0	cyclosporin_A	131,144	P-glycoprotein	47,61	cyclosporin A	P-glycoprotein	MESH:D016572	960	Chemical	Gene	reversal|compound|START_ENTITY alter|nmod|reversal alter|nsubj|Mutations Mutations|nmod|domain domain|nmod|END_ENTITY	Mutations in the sixth transmembrane domain of P-glycoprotein that alter the pattern of cross-resistance also alter sensitivity to cyclosporin_A reversal .
9374872	0	cyclosporin_A	81,94	P-glycoprotein	0,14	cyclosporin A	P-glycoprotein	MESH:D016572	287115(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY dimer|dep|effect dimer|nsubj|END_ENTITY	P-glycoprotein is a dimer in the kidney and brain capillary membranes : effect of cyclosporin_A and SDZ-PSC_833 .
9525837	0	cyclosporin_A	43,56	P-glycoprotein	108,122	cyclosporin A	P-glycoprotein	MESH:D016572	287115(Tax:10116)	Chemical	Gene	concentration|nmod|START_ENTITY Modulation|nmod|concentration Modulation|acl|expressing expressing|dobj|END_ENTITY	Modulation of doxorubicin concentration by cyclosporin_A in brain and testicular barrier tissues expressing P-glycoprotein in rats .
9885221	0	cyclosporin_A	126,139	P-glycoprotein	0,14	cyclosporin A	P-glycoprotein	MESH:D016572	5243	Chemical	Gene	function|nmod|START_ENTITY function|nsubj|expression expression|amod|END_ENTITY	P-glycoprotein expression on normal and abnormally expanded natural killer cells and inhibition of P-glycoprotein function by cyclosporin_A and its analogue , PSC833 .
10573362	0	cyclosporin_A	65,78	P-glycoproteins	46,61	cyclosporin A	P-glycoproteins	MESH:D016572	287115(Tax:10116)	Chemical	Gene	excretion|compound|START_ENTITY END_ENTITY|nmod|excretion	Effect of pharmacological modulation of liver P-glycoproteins on cyclosporin_A biliary excretion and cholestasis : a study in isolated perfused rat liver .
3179506	0	cyclosporin_A	70,83	Prolactin	0,9	cyclosporin A	Prolactin	MESH:D016572	5617	Chemical	Gene	regulation|nmod|START_ENTITY receptors|dep|regulation receptors|compound|END_ENTITY	Prolactin receptors on large granular lymphocytes : dual regulation by cyclosporin_A .
17262945	0	cyclosporin_A	21,34	arginine_vasopressin	106,126	cyclosporin A	arginine vasopressin	MESH:D016572	24221(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|acl|induced induced|nmod|END_ENTITY	Inhibitory effect of cyclosporin_A on growth and collagen synthesis of rat cardiac fibroblasts induced by arginine_vasopressin .
1463748	0	cyclosporin_A	22,35	cyclophilin	96,107	cyclosporin A	cyclophilin	MESH:D016572	9360	Chemical	Gene	structure|nmod|START_ENTITY bound|nsubj|structure bound|nmod|END_ENTITY	Solution structure of cyclosporin_A and a nonimmunosuppressive analog bound to fully deuterated cyclophilin .
18042735	0	cyclosporin_A	120,133	dual-leucine-zipper-bearing_kinase	18,52	cyclosporin A	dual-leucine-zipper-bearing kinase	MESH:D016572	26404(Tax:10090)	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of the dual-leucine-zipper-bearing_kinase and induction of beta-cell apoptosis by the immunosuppressive drug cyclosporin_A .
9787942	0	cyclosporin_A	20,33	endothelin-1	97,109	cyclosporin A	endothelin-1	MESH:D016572	1906	Chemical	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Diltiazem modulates cyclosporin_A induced renal hemodynamic effects but not its effect on plasma endothelin-1 .
10810233	0	cyclosporin_A	88,101	endothelin_1	19,31	cyclosporin A	endothelin 1	MESH:D016572	24323(Tax:10116)	Chemical	Gene	nephrotoxicity|compound|START_ENTITY Role|nmod|nephrotoxicity Role|nmod|END_ENTITY	Role of intrarenal endothelin_1 , endothelin_3 , and angiotensin_II expression in chronic cyclosporin_A nephrotoxicity in rats .
8393357	0	cyclosporin_A	11,24	erythropoietin	28,42	cyclosporin A	erythropoietin	MESH:D016572	2056	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|production production|compound|END_ENTITY	Effects of cyclosporin_A on erythropoietin production by the human Hep3B hepatoma cell line .
16332238	0	cyclosporin_A	10,23	inducible_nitric_oxide_synthase	45,76	cyclosporin A	inducible nitric oxide synthase	MESH:D016572	24599(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	Effect of cyclosporin_A on the expression of inducible_nitric_oxide_synthase in the gingiva of rats .
12644894	0	cyclosporin_A	78,91	insulin	20,27	cyclosporin A	insulin	MESH:D016572	3630	Chemical	Gene	transcription|nmod|START_ENTITY transcription|nsubj|Regulation Regulation|nmod|gene gene|compound|END_ENTITY	Regulation of human insulin gene transcription by the immunosuppressive drugs cyclosporin_A and tacrolimus at concentrations that inhibit calcineurin activity and involving the transcription factor CREB .
12425850	0	cyclosporin_A	11,24	intercellular_adhesion_molecule-1	42,75	cyclosporin A	intercellular adhesion molecule-1	MESH:D016572	3383	Chemical	Gene	START_ENTITY|nmod|levels levels|nmod|END_ENTITY	Effects of cyclosporin_A on the levels of intercellular_adhesion_molecule-1 expressed by oral fibroblasts .
3932520	0	cyclosporin_A	31,44	interleukin-2	80,93	cyclosporin A	interleukin-2	MESH:D016572	3558	Chemical	Gene	START_ENTITY|nmod|cascade cascade|compound|END_ENTITY	A comparison of the effects of cyclosporin_A , dexamethasone , and ouabain on the interleukin-2 cascade .
8762014	0	cyclosporin_A	56,69	interleukin-2	93,106	cyclosporin A	interleukin-2	MESH:D016572	3558	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|production production|compound|END_ENTITY	CD45RA + and CD45RO + T cells differ in susceptibility to cyclosporin_A mediated inhibition of interleukin-2 production .
2789115	0	cyclosporin_A	31,44	interleukin-2_receptor_alpha	71,99	cyclosporin A	interleukin-2 receptor alpha	MESH:D016572	3559	Chemical	Gene	START_ENTITY|nmod|induction induction|nmod|END_ENTITY	In vitro and in vivo action of cyclosporin_A on the induction of human interleukin-2_receptor_alpha and beta chains .
15286717	0	cyclosporin_A	22,35	interleukin-8	70,83	cyclosporin A	interleukin-8	MESH:D016572	3576	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|amod|END_ENTITY	Inhibitory effects of cyclosporin_A on calcium mobilization-dependent interleukin-8 expression and invasive potential of human glioblastoma U251MG cells .
10529615	0	cyclosporin_A	79,92	interleukin_5	113,126	cyclosporin A	interleukin 5	MESH:D016572	3567	Chemical	Gene	downregulation|nmod|START_ENTITY downregulation|nmod|END_ENTITY	Overexpression of CD11b on eosinophils in atopic_dermatitis : downregulation by cyclosporin_A and upregulation by interleukin_5 .
8842452	0	cyclosporin_A	58,71	p-glycoprotein	13,27	cyclosporin A	p-glycoprotein	MESH:D016572	5243	Chemical	Gene	absorption|nmod|START_ENTITY END_ENTITY|nmod|absorption	Relevance of p-glycoprotein for the enteral absorption of cyclosporin_A : in vitro-in vivo correlation .
10908115	0	cyclosporin_FR901459	29,49	P-glycoprotein	69,83	cyclosporin FR901459	P-glycoprotein	null	5243	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	The potent immunosuppressive cyclosporin_FR901459 inhibits the human P-glycoprotein and formyl peptide receptor functions .
9209689	0	cyclosporin_G	41,54	CYP_3A	15,21	cyclosporin G	CYP 3A	MESH:C045571	170509(Tax:10116)	Chemical	Gene	toxicity|nmod|START_ENTITY END_ENTITY|nmod|toxicity	Implication of CYP_3A in the toxicity of cyclosporin_G -LRB- CsG -RRB- , cyclosporin_A -LRB- CsA -RRB- and FK506 on rat hepatocytes in primary culture .
17357450	0	cyclosporin_a	15,28	MMP-9	50,55	cyclosporin a	MMP-9	MESH:D016572	4318	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Modulation of cyclosporin_a on the expression of MMP-9 AND MMP-2 of the first-trimester human trophoblast cells -RSB- .
17603247	0	cyclosporine	76,88	ADAMTS13	174,182	cyclosporine	ADAMTS13	MESH:D016572	11093	Chemical	Gene	thrombotic_thrombocytopenic_purpura|nmod|START_ENTITY treatment|nmod|thrombotic_thrombocytopenic_purpura treatment|nmod|END_ENTITY	Successful treatment of refractory thrombotic_thrombocytopenic_purpura with cyclosporine and corticosteroids in a patient with systemic_lupus_erythematosus and antibodies to ADAMTS13 .
18821711	0	cyclosporine	23,35	ADAMTS13	47,55	cyclosporine	ADAMTS13	MESH:D016572	11093	Chemical	Gene	therapy|compound|START_ENTITY therapy|nmod|END_ENTITY	Effect of prophylactic cyclosporine therapy on ADAMTS13 biomarkers in patients with idiopathic thrombotic_thrombocytopenic_purpura .
8356404	0	cyclosporine	17,29	CD23	71,75	cyclosporine	CD23	MESH:D016572	2208	Chemical	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	Up-regulation by cyclosporine -LRB- CsA -RRB- of the in vitro release of soluble CD23 -LRB- sCD23 -RRB- and of the in vitro production of IL-6 and IgM .
23222818	0	cyclosporine	114,126	CD8	79,82	cyclosporine	CD8	MESH:D016572	925	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Everolimus-treated renal transplant recipients have a more robust CMV-specific CD8 + T-cell response compared with cyclosporine - or mycophenolate-treated patients .
7541577	0	cyclosporine	15,27	CD8	84,87	cyclosporine	CD8	MESH:D016572	925	Chemical	Gene	Implication|nmod|START_ENTITY Implication|nmod|lymphocytosis lymphocytosis|nummod|END_ENTITY	Implication of cyclosporine in up-regulation of Bcl-2 expression and maintenance of CD8 lymphocytosis in cytomegalovirus-infected allograft recipients .
16827636	0	cyclosporine	20,32	CYP3A5	76,82	cyclosporine	CYP3A5	MESH:D016572	1577	Chemical	Gene	concentration|amod|START_ENTITY concentration|nmod|END_ENTITY	Association between cyclosporine concentration and genetic polymorphisms of CYP3A5 and MDR1 during the early stage after renal transplantation .
18180803	0	cyclosporine	117,129	CYP3A5	0,6	cyclosporine	CYP3A5	MESH:D016572	1577	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|genotype genotype|compound|END_ENTITY	CYP3A5 genotype is associated with longer patient survival after kidney transplantation and long-term treatment with cyclosporine .
3043795	0	cyclosporine	44,56	Cyclophilin	0,11	cyclosporine	Cyclophilin	MESH:D016572	9360	Chemical	Gene	target|nmod|START_ENTITY END_ENTITY|appos|target	Cyclophilin , a primary molecular target for cyclosporine .
21593166	4	cyclosporine	507,519	CypA	483,487	cyclosporine	CypA	MESH:D016572	5478	Chemical	Gene	inhibitors|nmod|START_ENTITY inhibitors|compound|END_ENTITY	CypA inhibitors such as cyclosporine -LRB- CsA -RRB- have been shown to inhibit hepatitis_C_virus _ -LRB- HCV -RRB- replication .
11360881	0	cyclosporine	119,131	Endothelin-1	0,12	cyclosporine	Endothelin-1	MESH:D016572	1906	Chemical	Gene	increase|nmod|START_ENTITY increase|nsubj|END_ENTITY	Endothelin-1 circulating levels increase in patients with orthotopic heart transplantation and in chronic therapy with cyclosporine .
3278425	0	cyclosporine	123,135	HLA_A	14,19	cyclosporine	HLA A	MESH:D016572	3105	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|impact impact|nmod|END_ENTITY	The impact of HLA_A , B , and DR blood transfusions and immune responder status on cardiac allograft recipients treated with cyclosporine .
17617853	0	cyclosporine	11,23	IL-2	61,65	cyclosporine	IL-2	MESH:D016572	3558	Chemical	Gene	Effects|nmod|START_ENTITY Effects|dep|role role|nmod|END_ENTITY	Effects of cyclosporine on transplant tolerance : the role of IL-2 .
24462674	0	cyclosporine	51,63	IL-2	93,97	cyclosporine	IL-2	MESH:D016572	116562(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|modulation modulation|nmod|cascade cascade|amod|TGF-b1 TGF-b1|dep|COX-2 COX-2|dep|/ /|compound|END_ENTITY	Celecoxib offsets the negative renal influences of cyclosporine via modulation of the TGF-b1 / IL-2 / COX-2 / endothelin ET -LRB- B -RRB- receptor cascade .
26676223	0	cyclosporine	16,28	IL-2	60,64	cyclosporine	IL-2	MESH:D016572	403989(Tax:9615)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of oral cyclosporine on canine T-cell expression of IL-2 and IFN-gamma across a 12-h dosing interval .
8655354	0	cyclosporine	93,105	IL-2	21,25	cyclosporine	IL-2	MESH:D016572	3558	Chemical	Gene	immunosuppressed|nmod|START_ENTITY immunosuppressed|nsubj|monitoring monitoring|compound|END_ENTITY	Longitudinal induced IL-2 mRNA monitoring in renal transplant patients immunosuppressed with cyclosporine and in unmodified canine renal_transplant_rejection .
22897149	0	cyclosporine	57,69	Insulin	0,7	cyclosporine	Insulin	MESH:D016572	3630	Chemical	Gene	tacrolimus|nmod|START_ENTITY independence|nmod|tacrolimus independence|compound|END_ENTITY	Insulin independence after conversion from tacrolimus to cyclosporine in islet transplantation .
10928765	0	cyclosporine	98,110	Interleukin-6	0,13	cyclosporine	Interleukin-6	MESH:D016572	3569	Chemical	Gene	emulsion|amod|START_ENTITY treated|nmod|emulsion treated|nsubj|levels levels|amod|END_ENTITY	Interleukin-6 levels in the conjunctival epithelium of patients with dry_eye_disease treated with cyclosporine ophthalmic emulsion .
15592326	0	cyclosporine	31,43	MDR-1	150,155	cyclosporine	MDR-1	MESH:D016572	5243	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY pharmacokinetics|nmod|END_ENTITY	Population pharmacokinetics of cyclosporine in kidney and heart transplant recipients and the influence of ethnicity and genetic polymorphisms in the MDR-1 , CYP3A4 , and CYP3A5 genes .
3160142	0	cyclosporine	10,22	MHC_class_II_antigen	26,46	cyclosporine	MHC class II antigen	MESH:D016572	3128	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effect of cyclosporine on MHC_class_II_antigen expression on arterial and venous endothelium in vitro .
10755319	0	cyclosporine	20,32	P-glycoprotein	85,99	cyclosporine	P-glycoprotein	MESH:D016572	5243	Chemical	Gene	START_ENTITY|nmod|pharmacodynamics pharmacodynamics|nmod|trial trial|acl|reverse reverse|dobj|END_ENTITY	Effect of high-dose cyclosporine on etoposide pharmacodynamics in a trial to reverse P-glycoprotein -LRB- MDR1 gene -RRB- mediated drug resistance .
11230802	0	cyclosporine	85,97	P-glycoprotein	61,75	cyclosporine	P-glycoprotein	MESH:D016572	5243	Chemical	Gene	SDZ_PSC_833|amod|START_ENTITY END_ENTITY|nmod|SDZ_PSC_833	HIV protease inhibitor ritonavir : a more potent inhibitor of P-glycoprotein than the cyclosporine analog SDZ_PSC_833 .
14526408	0	cyclosporine	59,71	P-glycoprotein	34,48	cyclosporine	P-glycoprotein	MESH:D016572	5243	Chemical	Gene	bioavailability|amod|START_ENTITY depresses|dobj|bioavailability depresses|nsubj|expression expression|nmod|END_ENTITY	Enhanced expression of enterocyte P-glycoprotein depresses cyclosporine bioavailability in a recipient of living donor liver transplantation .
15084935	0	cyclosporine	96,108	P-glycoprotein	152,166	cyclosporine	P-glycoprotein	MESH:D016572	5243	Chemical	Gene	effects|nmod|START_ENTITY related|nsubjpass|effects related|nmod|expression expression|amod|END_ENTITY	Whole-blood cultures from renal-transplant patients stimulated ex vivo show that the effects of cyclosporine on lymphocyte proliferation are related to P-glycoprotein expression .
16837925	0	cyclosporine	26,38	P-glycoprotein	8,22	cyclosporine	P-glycoprotein	MESH:D016572	5243	Chemical	Gene	cytotoxicity|amod|START_ENTITY Role|nmod|cytotoxicity Role|nmod|END_ENTITY	Role of P-glycoprotein in cyclosporine cytotoxicity in the cyclosporine-sirolimus interaction .
19100412	0	cyclosporine	20,32	P-glycoprotein	71,85	cyclosporine	P-glycoprotein	MESH:D016572	5243	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|nmod|END_ENTITY	Different effect of cyclosporine and tacrolimus on renal expression of P-glycoprotein in human kidney transplantation .
19356075	0	cyclosporine	69,81	P-glycoprotein	42,56	cyclosporine	P-glycoprotein	MESH:D016572	5243	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Influence of ABCB1 gene polymorphisms and P-glycoprotein activity on cyclosporine pharmacokinetics in peripheral blood mononuclear cells in healthy volunteers .
19617341	0	cyclosporine	11,23	P-glycoprotein	38,52	cyclosporine	P-glycoprotein	MESH:D016572	5243	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|activity activity|amod|END_ENTITY	Imaging of cyclosporine inhibition of P-glycoprotein activity using 11C-verapamil in the brain : studies of healthy humans .
21466223	0	cyclosporine	51,63	P-glycoprotein	118,132	cyclosporine	P-glycoprotein	MESH:D016572	5243	Chemical	Gene	bioavailability|nmod|START_ENTITY reduced|dobj|bioavailability reduced|advcl|activating activating|dobj|END_ENTITY	Quercetin and rutin reduced the bioavailability of cyclosporine from Neoral , an immunosuppressant , through activating P-glycoprotein and CYP_3A4 .
26634287	0	cyclosporine	43,55	P-glycoprotein	78,92	cyclosporine	P-glycoprotein	MESH:D016572	287115(Tax:10116)	Chemical	Gene	START_ENTITY|appos|substrate substrate|nmod|END_ENTITY	Rhubarb decreased the systemic exposure of cyclosporine , a probe substrate of P-glycoprotein and CYP_3A .
9333100	0	cyclosporine	98,110	P-glycoprotein	19,33	cyclosporine	P-glycoprotein	MESH:D016572	5243	Chemical	Gene	bioavailability|nmod|START_ENTITY variation|nmod|bioavailability Role|nmod|variation Role|nmod|END_ENTITY	Role of intestinal P-glycoprotein -LRB- mdr1 -RRB- in interpatient variation in the oral bioavailability of cyclosporine .
16926534	0	cyclosporine	10,22	connective_tissue_growth_factor	58,89	cyclosporine	connective tissue growth factor	MESH:D016572	64032(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	Effect of cyclosporine and sirolimus on the expression of connective_tissue_growth_factor in rat experimental chronic nephrotoxicity .
25124319	0	cyclosporine	51,63	cyclooxygenase_1_and_2	19,41	cyclosporine	cyclooxygenase 1 and 2	MESH:D016572	5742;5743	Chemical	Gene	induced|compound|START_ENTITY END_ENTITY|nmod|induced	Elevated levels of cyclooxygenase_1_and_2 in human cyclosporine induced gingival_overgrowth .
8420039	0	cyclosporine	67,79	granzyme_A	11,21	cyclosporine	granzyme A	MESH:D016572	266708(Tax:10116)	Chemical	Gene	use|nmod|START_ENTITY use|nmod|END_ENTITY	The use of granzyme_A as a marker of heart_transplant_rejection in cyclosporine or anti-CD4 monoclonal antibody-treated rats .
1557689	0	cyclosporine	11,23	insulin	27,34	cyclosporine	insulin	MESH:D016572	483665(Tax:9615)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of cyclosporine on insulin secretion and insulin sensitivity in dogs with intrasplenic islet autotransplants .
1604471	0	cyclosporine	105,117	insulin	31,38	cyclosporine	insulin	MESH:D016572	483665(Tax:9615)	Chemical	Gene	treatment|compound|START_ENTITY Recovery|nmod|treatment Recovery|nmod|END_ENTITY	Recovery and hypersecretion of insulin and reversal of insulin resistance after withdrawal of short-term cyclosporine treatment .
1604471	0	cyclosporine	105,117	insulin	55,62	cyclosporine	insulin	MESH:D016572	483665(Tax:9615)	Chemical	Gene	treatment|compound|START_ENTITY Recovery|nmod|treatment Recovery|nmod|resistance resistance|compound|END_ENTITY	Recovery and hypersecretion of insulin and reversal of insulin resistance after withdrawal of short-term cyclosporine treatment .
18709005	0	cyclosporine	123,135	insulin	23,30	cyclosporine	insulin	MESH:D016572	3630	Chemical	Gene	therapy|nmod|START_ENTITY patients|nmod|therapy transplantation|nmod|patients resistance|nmod|transplantation resistance|compound|END_ENTITY	Clinical importance of insulin resistance after renal transplantation in patients on triple immunosuppressive therapy with cyclosporine , corticosteroids and mycophenolate mofetil .
2180152	0	cyclosporine	33,45	insulin	14,21	cyclosporine	insulin	MESH:D016572	483665(Tax:9615)	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of insulin release by cyclosporine and production of peripheral insulin resistance in the dog .
2180152	0	cyclosporine	33,45	insulin	75,82	cyclosporine	insulin	MESH:D016572	483665(Tax:9615)	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	Inhibition of insulin release by cyclosporine and production of peripheral insulin resistance in the dog .
25143337	0	cyclosporine	73,85	interleukin-2	24,37	cyclosporine	interleukin-2	MESH:D016572	3558	Chemical	Gene	concentrations|nmod|START_ENTITY concentrations|nmod|END_ENTITY	Serum concentrations of interleukin-2 and tumour_necrosis_factor-a under cyclosporine versus acitretin treatment in plaque-type_psoriasis .
3261818	0	cyclosporine	19,31	interleukin-2	46,59	cyclosporine	interleukin-2	MESH:D016572	16183(Tax:10090)	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|production production|compound|END_ENTITY	Cimetidine reduces cyclosporine inhibition of interleukin-2 production .
1989345	0	cyclosporine	22,34	interleukin-6	38,51	cyclosporine	interleukin-6	MESH:D016572	3569	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|amod|END_ENTITY	The in vivo effect of cyclosporine on interleukin-6 gene expression in renal transplant recipients .
8159020	0	cyclosporine	15,27	interleukin-6	55,68	cyclosporine	interleukin-6	MESH:D016572	24498(Tax:10116)	Chemical	Gene	Combination|nmod|START_ENTITY suppresses|nsubj|Combination suppresses|dobj|production production|amod|END_ENTITY	Combination of cyclosporine and splenectomy suppresses interleukin-6 production and major histocompatibility complex class II expression and prolongs cardiac xenograft survival .
2645720	0	cyclosporine	19,31	lymphokine	49,59	cyclosporine	lymphokine	MESH:D016572	3558	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Similar effects of cyclosporine and verapamil on lymphokine , interleukin_2 receptor , and proto-oncogene expression .
11222523	0	cyclosporine	10,22	mucin	39,44	cyclosporine	mucin	MESH:D016572	442975(Tax:9615)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of cyclosporine on conjunctival mucin in a canine keratoconjunctivitis_sicca model .
6231749	0	cyclosporine	14,26	ornithine_decarboxylase	30,53	cyclosporine	ornithine decarboxylase	MESH:D016572	4953	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|induction induction|amod|END_ENTITY	The effect of cyclosporine on ornithine_decarboxylase induction with mitogens , antigens , and lymphokines .
21559677	0	cyclosporine	102,114	p-glycoprotein	13,27	cyclosporine	p-glycoprotein	MESH:D016572	5243	Chemical	Gene	derivative|amod|START_ENTITY psc-833|appos|derivative mediated|nmod|psc-833 mediated|nsubj|Reversion Reversion|nmod|END_ENTITY	Reversion of p-glycoprotein mediated multidrug-resistance to vincristine and adriamycin by psc-833 , a cyclosporine derivative in human neuroblastoma cell-lines .
1848730	0	cyclosporine	104,116	thrombomodulin	71,85	cyclosporine	thrombomodulin	MESH:D016572	281529(Tax:9913)	Chemical	Gene	induced|nmod|START_ENTITY induced|nmod|END_ENTITY	Decrease in endothelial cell-dependent protein C activation induced by thrombomodulin by treatment with cyclosporine .
7570983	0	cyclosporine	68,80	transforming_growth_factor-beta_1	14,47	cyclosporine	transforming growth factor-beta 1	MESH:D016572	7040	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of transforming_growth_factor-beta_1 and its receptor by cyclosporine in human T lymphocytes .
7828718	0	cyclosporine	66,78	transforming_growth_factor-beta_1	15,48	cyclosporine	transforming growth factor-beta 1	MESH:D016572	7040	Chemical	Gene	Stimulation|nmod|START_ENTITY Stimulation|nmod|transcription transcription|amod|END_ENTITY	Stimulation of transforming_growth_factor-beta_1 transcription by cyclosporine .
7544037	0	cyclosporine	32,44	vascular_cell_adhesion_molecule-1	88,121	cyclosporine	vascular cell adhesion molecule-1	MESH:D016572	100008901(Tax:9986)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|amod|END_ENTITY	The direct effect of injectable cyclosporine and its vehicle , cremophor , on endothelial vascular_cell_adhesion_molecule-1 expression .
9777701	0	cyclosporine_A	11,25	CD18	46,50	cyclosporine A	CD18	MESH:D016572	309684(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of cyclosporine_A and methotrexate on CD18 expression in recipients of rat cardiac allografts .
1311469	0	cyclosporine_A	33,47	CD27	14,18	cyclosporine A	CD27	MESH:D016572	939	Chemical	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Inhibition of CD27 expression by cyclosporine_A ; role of IL-2 .
15450954	0	cyclosporine_A	23,37	CYP3A5	54,60	cyclosporine A	CYP3A5	MESH:D016572	1577	Chemical	Gene	metabolism|nmod|START_ENTITY END_ENTITY|nsubj|metabolism	In vitro metabolism of cyclosporine_A by human kidney CYP3A5 .
11059862	0	cyclosporine_A	19,33	HSP70	0,5	cyclosporine A	HSP70	MESH:D016572	266759(Tax:10116)	Chemical	Gene	induction|nmod|START_ENTITY induction|nummod|END_ENTITY	HSP70 induction by cyclosporine_A in cultured rat hepatocytes : effect of vitamin_E succinate .
8218831	0	cyclosporine_A	60,74	IL-2	93,97	cyclosporine A	IL-2	MESH:D016572	16183(Tax:10090)	Chemical	Gene	enhancement|nmod|START_ENTITY enhancement|nmod|END_ENTITY	Post-thymectomy organ-specific autoimmunity : enhancement by cyclosporine_A and inhibition by IL-2 .
7949151	0	cyclosporine_A	50,64	Interleukin-6	0,13	cyclosporine A	Interleukin-6	MESH:D016572	3569	Chemical	Gene	induction|nmod|START_ENTITY END_ENTITY|acl|induction	Interleukin-6 and Epstein-Barr_virus induction by cyclosporine_A : potential role in lymphoproliferative_disease .
8914013	0	cyclosporine_A	11,25	NBL-1	86,91	cyclosporine A	NBL-1	MESH:D016572	535280(Tax:9913)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of cyclosporine_A on Na,K-ATPase expression in the renal epithelial cell line NBL-1 .
10949181	0	cyclosporine_A	24,38	NFkappaB	128,136	cyclosporine A	NFkappaB	MESH:D016572	18033(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|induction induction|nmod|END_ENTITY	Differential effects of cyclosporine_A , methylprednisolone , mycophenolate , and rapamycin on CD154 induction and requirement for NFkappaB : implications for tolerance induction .
2600452	0	cyclosporine_A	29,43	ODC	100,103	cyclosporine A	ODC	MESH:D016572	24609(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|appos|END_ENTITY	Dose-dependent inhibition by cyclosporine_A of the induction of pancreatic_ornithine_decarboxylase -LRB- ODC -RRB- in rats .
16497638	0	cyclosporine_A	84,98	Vascular_endothelial_growth_factor	0,34	cyclosporine A	Vascular endothelial growth factor	MESH:D016572	7422	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|END_ENTITY	Vascular_endothelial_growth_factor in children with nephrotic_syndrome treated with cyclosporine_A .
19577762	0	cyclosporine_A	127,141	chemokine_receptor_5	86,106	cyclosporine A	chemokine receptor 5	MESH:D016572	12774(Tax:10090)	Chemical	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	Suppression of acute and chronic cardiac allograft rejection in mice by inhibition of chemokine_receptor_5 in combination with cyclosporine_A .
18725544	0	cyclosporine_A	104,118	cytochrome_P450_3A	58,76	cyclosporine A	cytochrome P450 3A	MESH:D016572	170509(Tax:10116)	Chemical	Gene	absorption|nmod|START_ENTITY END_ENTITY|nmod|absorption	Contribution of down-regulation of intestinal and hepatic cytochrome_P450_3A to increased absorption of cyclosporine_A in a rat nephrosis model .
9368918	0	cyclosporine_A	14,28	gamma-glutamyl_transpeptidase	63,92	cyclosporine A	gamma-glutamyl transpeptidase	MESH:D016572	14598(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|nmod|END_ENTITY	The effect of cyclosporine_A and amlodipine on the activity of gamma-glutamyl_transpeptidase in mouse cerebral cortex .
15702787	0	cyclosporine_A	11,25	interleukin-10	63,77	cyclosporine A	interleukin-10	MESH:D016572	3586	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|nmod|END_ENTITY	-LSB- Effect of cyclosporine_A on the trophoblast cell secretion of interleukin-10 and interferon-gamma in early pregnancy -RSB- .
9052855	0	cyclosporine_A	16,30	tumor_necrosis_factor-alpha	76,103	cyclosporine A	tumor necrosis factor-alpha	MESH:D016572	24835(Tax:10116)	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|production production|amod|END_ENTITY	Pentoxifylline , cyclosporine_A and taurolidine inhibit endotoxin-stimulated tumor_necrosis_factor-alpha production in rat mesangial cell cultures .
14627919	0	cyclosporine_A	139,153	vascular_endothelial_growth_factor	85,119	cyclosporine A	vascular endothelial growth factor	MESH:D016572	7422	Chemical	Gene	mimics|nsubj|START_ENTITY blocks|parataxis|mimics blocks|dobj|-6 -6|dep|END_ENTITY	C-jun_N-terminal_kinase -LRB- JNK -RRB- inhibitor , SP600125 , blocks interleukin _ -LRB- IL -RRB- -6 - induced vascular_endothelial_growth_factor -LRB- VEGF -RRB- production : cyclosporine_A partially mimics this inhibitory effect .
24964791	0	cyclosporine_a	50,64	Nrf2	72,76	cyclosporine a	Nrf2	MESH:D016572	4780	Chemical	Gene	START_ENTITY|nmod|pathway pathway|amod|END_ENTITY	Systems biology modeling of omics data : effect of cyclosporine_a on the Nrf2 pathway in human renal cells .
23964991	0	cyclosporins	43,55	CD147	84,89	cyclosporins	CD147	MESH:D003524	12215(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY mediated|nsubjpass|effects mediated|nmod|END_ENTITY	Anti-inflammatory effects of extracellular cyclosporins are exclusively mediated by CD147 .
11561846	0	cypermethrin	63,75	DEF	56,59	cypermethrin	DEF	MESH:C017160	27042	Chemical	Gene	toxicity|compound|START_ENTITY END_ENTITY|nmod|toxicity	Pharmacokinetic mechanisms associated with synergism by DEF of cypermethrin toxicity in larval and adult Helicoverpa zea , Spodoptera frugiperda , and Agrotis ipsilon -LRB- Lepidoptera : Noctuidae -RRB- .
26125603	0	cypermethrin	22,34	androgen_receptor	60,77	cypermethrin	androgen receptor	MESH:C017160	367	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activation activation|compound|END_ENTITY	Antagonism effects of cypermethrin on interleukin-6-induced androgen_receptor activation .
17557908	0	cyproconazole	23,36	constitutive_androstane_receptor	72,104	cyproconazole	constitutive androstane receptor	MESH:C093628	12355(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|role role|nmod|END_ENTITY	Mouse liver effects of cyproconazole , a triazole fungicide : role of the constitutive_androstane_receptor .
12455838	0	cyproheptadine	123,137	ACTH	28,32	cyproheptadine	ACTH	MESH:D003533	100071524(Tax:9796)	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|concentrations concentrations|appos|END_ENTITY	Plasma adrenocorticotropin -LRB- ACTH -RRB- concentrations and clinical response in horses treated for equine_Cushing 's _ disease with cyproheptadine or pergolide .
186479	0	cyproheptadine	17,31	ACTH	53,57	cyproheptadine	ACTH	MESH:D003533	5443	Chemical	Gene	START_ENTITY|advcl|decreasing decreasing|dobj|END_ENTITY	Effectiveness of cyproheptadine in decreasing plasma ACTH concentrations in Nelson 's _ syndrome .
2161298	0	cyproheptadine	14,28	ACTH	60,64	cyproheptadine	ACTH	MESH:D003533	5443	Chemical	Gene	and/or|amod|START_ENTITY effect|nmod|and/or bromocriptine|nsubj|effect bromocriptine|nmod|END_ENTITY	The effect of cyproheptadine and/or bromocriptine on plasma ACTH levels in patients cured of Cushing 's _ disease by bilateral adrenalectomy .
8796367	0	cyproheptadine	10,24	ACTH	37,41	cyproheptadine	ACTH	MESH:D003533	5443	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of cyproheptadine on episodic ACTH and cortisol secretion .
7011596	0	cyproheptadine	11,25	PRL	72,75	cyproheptadine	PRL	MESH:D003533	5617	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|nmod|END_ENTITY	Effects of cyproheptadine on insulin-induced hypoglycaemia secretion of PRL , GH and cortisol .
311717	0	cyproheptadine	14,28	corticotrophin_releasing_factor	47,78	cyproheptadine	corticotrophin releasing factor	MESH:D003533	1392	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|release release|nmod|END_ENTITY	The effect of cyproheptadine on the release of corticotrophin_releasing_factor .
1971804	0	cyproheptadine	14,28	growth_hormone	39,53	cyproheptadine	growth hormone	MESH:D003533	2688	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of cyproheptadine on plasma growth_hormone -LRB- GH -RRB- and on somatostatin response to GH-releasing hormone in man .
2591063	0	cyproheptadine	21,35	growth_hormone	56,70	cyproheptadine	growth hormone	MESH:D003533	2688	Chemical	Gene	therapy|compound|START_ENTITY therapy|acl|lowering lowering|dobj|levels levels|amod|END_ENTITY	Failure of long-term cyproheptadine therapy in lowering growth_hormone levels in acromegaly .
2596504	0	cyproheptadine	102,116	growth_hormone	20,34	cyproheptadine	growth hormone	MESH:D003533	2688	Chemical	Gene	doses|nmod|START_ENTITY effect|nmod|doses rhythm|dep|effect rhythm|nmod|END_ENTITY	Nocturnal rhythm of growth_hormone in Duchenne patients : effect of different doses of mazindol and/or cyproheptadine .
3794875	0	cyproheptadine	48,62	growth_hormone	106,120	cyproheptadine	growth hormone	MESH:D003533	2688	Chemical	Gene	Enhancement|nmod|START_ENTITY Enhancement|nmod|hypopituitarism hypopituitarism|acl|receiving receiving|dobj|therapy therapy|amod|END_ENTITY	Enhancement of linear growth and weight_gain by cyproheptadine in children with hypopituitarism receiving growth_hormone therapy .
6799379	0	cyproheptadine	19,33	growth_hormone	54,68	cyproheptadine	growth hormone	MESH:D003533	2688	Chemical	Gene	START_ENTITY|nmod|response response|amod|END_ENTITY	The effect of TRH , cyproheptadine and pimozide on the growth_hormone response to intramuscular glucagon .
875737	0	cyproheptadine	49,63	growth_hormone	21,35	cyproheptadine	growth hormone	MESH:D003533	2688	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Suppression Suppression|nmod|END_ENTITY	Suppression of human growth_hormone secretion by cyproheptadine .
15056814	0	cyproheptadine	35,49	insulin	14,21	cyproheptadine	insulin	MESH:D003533	3630	Chemical	Gene	synthesis|nmod|START_ENTITY synthesis|compound|END_ENTITY	Inhibition of insulin synthesis by cyproheptadine : effects on translation .
16418149	0	cyproheptadine	10,24	leptin	34,40	cyproheptadine	leptin	MESH:D003533	3952	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|compound|END_ENTITY	Effect of cyproheptadine on serum leptin levels .
6109449	0	cyproheptadine	10,24	prolactin	58,67	cyproheptadine	prolactin	MESH:D003533	5617	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|stimulation stimulation|nmod|END_ENTITY	Effect of cyproheptadine on chlorpromazine stimulation of prolactin in women .
12695529	0	cyproterone_acetate	38,57	Glucocorticoid_receptor	0,23	cyproterone acetate	Glucocorticoid receptor	MESH:D017373	2908	Chemical	Gene	antagonism|nmod|START_ENTITY antagonism|nsubj|END_ENTITY	Glucocorticoid_receptor antagonism by cyproterone_acetate and RU486 .
566170	0	cyproterone_acetate	77,96	Sex_hormone_binding_globulin	0,28	cyproterone acetate	Sex hormone binding globulin	MESH:D017373	6462	Chemical	Gene	steroids|amod|START_ENTITY the|nmod|steroids capacity|nmod|the END_ENTITY|dep|capacity	Sex_hormone_binding_globulin : binding capacity and studies on the binding of cyproterone_acetate and other steroids .
2530403	0	cyproterone_acetate	80,99	Testosterone-estradiol_binding_globulin	0,39	cyproterone acetate	Testosterone-estradiol binding globulin	MESH:D017373	6462	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|END_ENTITY	Testosterone-estradiol_binding_globulin -LRB- TeBG -RRB- in hirsute patients treated with cyproterone_acetate -LRB- CPA -RRB- and percutaneous estradiol .
9272420	0	cyproterone_acetate	194,213	insulin-like_growth_factor-I	6,34	cyproterone acetate	insulin-like growth factor-I	MESH:D017373	3479	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|END_ENTITY	Serum insulin-like_growth_factor-I -LRB- IGF-I -RRB- and IGF_binding_protein-3 levels in children with precocious puberty treated with gonadotropin-releasing_hormone analog without or in combination with cyproterone_acetate .
411573	0	cyproterone_acetate	10,29	prolactin	33,42	cyproterone acetate	prolactin	MESH:D017373	707052(Tax:9544)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of cyproterone_acetate on prolactin secretion in the female Rhesus_monkey .
78873	0	cyproterone_acetate	141,160	prolactin	25,34	cyproterone acetate	prolactin	MESH:D017373	5617	Chemical	Gene	-RSB-|amod|START_ENTITY containing|dobj|-RSB- concentrations|acl|containing concentrations|nmod|END_ENTITY	-LSB- Serum concentrations of prolactin , growth_hormone , and alpha-fetoprotein under long-term administration of an oral contraceptive containing cyproterone_acetate -LRB- author 's transl -RRB- -RSB- .
6226532	0	cyproterone_acetate	15,34	sex_hormone_binding_globulin	40,68	cyproterone acetate	sex hormone binding globulin	MESH:D017373	6462	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of cyproterone_acetate with sex_hormone_binding_globulin of monkey plasma .
11439107	0	cyritestin	6,16	CYRN1	24,29	cyritestin	CYRN1	null	1587	Chemical	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	Human cyritestin genes -LRB- CYRN1 and CYRN2 -RRB- are non-functional .
19007756	0	cystamine	48,57	Tissue-type_transglutaminase	0,28	cystamine	Tissue-type transglutaminase	MESH:D003538	56083(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|amod|END_ENTITY	Tissue-type_transglutaminase and the effects of cystamine on intracerebral_hemorrhage-induced brain_edema and neurological_deficits .
24639	0	cystamine	59,68	gamma-glutamylcysteine_synthetase	22,55	cystamine	gamma-glutamylcysteine synthetase	MESH:D003538	2729	Chemical	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of human gamma-glutamylcysteine_synthetase by cystamine .
8335636	0	cystathionine	59,72	CYS3	40,44	cystathionine	CYS3	MESH:D003540	851221(Tax:4932)	Chemical	Gene	START_ENTITY|nsubj|expression expression|nmod|encoding encoding|compound|END_ENTITY	Cloning and bacterial expression of the CYS3 gene encoding cystathionine gamma-lyase of Saccharomyces_cerevisiae and the physicochemical and enzymatic properties of the protein .
8511966	0	cystathionine	117,130	CYS3	31,35	cystathionine	CYS3	MESH:D003540	851221(Tax:4932)	Chemical	Gene	START_ENTITY|nsubj|localization localization|nmod|END_ENTITY	Physical localization of yeast CYS3 , a gene whose product resembles the rat gamma-cystathionase and Escherichia_coli cystathionine gamma-synthase enzymes .
1860901	0	cystathionine	60,73	phenylalanine_hydroxylase	33,58	cystathionine	phenylalanine hydroxylase	MESH:D003540	18478(Tax:10090)	Chemical	Gene	synthase|amod|START_ENTITY synthase|amod|END_ENTITY	BWTG3 hepatoma cells can acquire phenylalanine_hydroxylase , cystathionine synthase and CPS-I without genetic manipulation , but activation of the silent OTC gene requires cell fusion with hepatocytes .
14678520	0	cystatin	85,93	cathepsin_B	14,25	cystatin	cathepsin B	null	1508	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of cathepsin_B and L expression in vitro in gastric_cancer tissues by egg cystatin .
8774861	0	cystatin	46,54	cathepsin_C	21,32	cystatin	cathepsin C	null	1075	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of human cathepsin_C with chicken cystatin .
1515069	0	cystatin	117,125	cathepsin_L	105,116	cystatin	cathepsin L	null	1514	Chemical	Gene	complexes|compound|START_ENTITY complexes|amod|END_ENTITY	Characterisation of the activity and stability of single-chain cathepsin_L and of proteolytically active cathepsin_L / cystatin complexes .
17048522	0	cystatin	54,62	cysteine_protease	26,43	cystatin	cysteine protease	null	1508	Chemical	Gene	START_ENTITY|nsubj|delivery delivery|nmod|inhibitor inhibitor|amod|END_ENTITY	Intracellular delivery of cysteine_protease inhibitor cystatin by polymeric nanoparticles .
1801734	0	cystatins	43,52	cathepsin_S	28,39	cystatins	cathepsin S	MESH:D055333	1520	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Tight-binding inhibition of cathepsin_S by cystatins .
9871765	0	cystazosin	109,119	alpha_1D-adrenoceptor	124,145	cystazosin	alpha 1D-adrenoceptor	null	146	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Search for alpha 1-adrenoceptor subtypes selective antagonists : design , synthesis and biological activity of cystazosin , an alpha_1D-adrenoceptor antagonist .
9403786	0	cysteamine	73,83	Growth_hormone	0,14	cysteamine	Growth hormone	MESH:D003543	81668(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY interaction|nmod|effect interaction|compound|END_ENTITY	Growth_hormone and somatostatin interaction in the ulcerogenic effect of cysteamine in female rats .
18753449	0	cysteamine	37,47	Leptin	0,6	cysteamine	Leptin	MESH:D003543	373955(Tax:9031)	Chemical	Gene	effects|nmod|START_ENTITY involved|nmod|effects involved|nsubjpass|END_ENTITY	Leptin is involved in the effects of cysteamine on egg laying of hens , characteristics of eggs , and posthatch growth of broiler offspring .
1336994	0	cysteamine	85,95	Prolactin	0,9	cysteamine	Prolactin	MESH:D003543	19109(Tax:10090)	Chemical	Gene	treated|nmod|START_ENTITY mice|acl|treated secretagogues|nmod|mice secretagogues|nsubj|END_ENTITY	Prolactin and prolactin secretagogues reverse immunosuppression in mice treated with cysteamine , glucocorticoids , or cyclosporin-A .
2860015	0	cysteamine	26,36	Somatostatin	0,12	cysteamine	Somatostatin	MESH:D003543	24797(Tax:10116)	Chemical	Gene	depletion|nmod|START_ENTITY depletion|compound|END_ENTITY	Somatostatin depletion by cysteamine : mechanism and implication for duodenal ulceration .
3242778	0	cysteamine	18,28	aryl_hydrocarbon_hydroxylase	54,82	cysteamine	aryl hydrocarbon hydroxylase	MESH:D003543	13076(Tax:10090)	Chemical	Gene	treatment|compound|START_ENTITY Effect|nmod|treatment END_ENTITY|nsubj|Effect	Effect of chronic cysteamine treatment on mouse liver aryl_hydrocarbon_hydroxylase activity .
6142843	0	cysteamine	10,20	gastrin	37,44	cysteamine	gastrin	MESH:D003543	25320(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|nmod|END_ENTITY	Effect of cysteamine on secretion of gastrin and somatostatin from the rat stomach .
6498088	0	cysteamine	87,97	gastrin	73,80	cysteamine	gastrin	MESH:D003543	25320(Tax:10116)	Chemical	Gene	administration|amod|START_ENTITY END_ENTITY|nmod|administration	Gastric mucosal histamine , histamine formation capacity -LRB- HFC -RRB- and plasma gastrin after cysteamine administration .
913972	0	cysteamine	21,31	gastrin	67,74	cysteamine	gastrin	MESH:D003543	25320(Tax:10116)	Chemical	Gene	ulcerogens|amod|START_ENTITY stimulate|nsubj|ulcerogens stimulate|dobj|levels levels|compound|END_ENTITY	Duodenal ulcerogens , cysteamine and propionitrile , stimulate serum gastrin levels in the rat .
8529029	0	cysteamine	11,21	growth_hormone	35,49	cysteamine	growth hormone	MESH:D003543	443329(Tax:9940)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|release release|amod|END_ENTITY	Effects of cysteamine on pulsatile growth_hormone release and plasma insulin concentrations in sheep .
17712144	0	cysteamine	36,46	inducible_nitric_oxide_synthase	67,98	cysteamine	inducible nitric oxide synthase	MESH:D003543	24599(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|induction induction|nmod|END_ENTITY	Effect of thiol-containing molecule cysteamine on the induction of inducible_nitric_oxide_synthase in hepatocytes .
1943468	0	cysteamine	26,36	prolactin	50,59	cysteamine	prolactin	MESH:D003543	24683(Tax:10116)	Chemical	Gene	Comparison|nmod|START_ENTITY Comparison|acl|depleting depleting|dobj|immunoreactivity immunoreactivity|compound|END_ENTITY	Comparison of efficacy of cysteamine in depleting prolactin immunoreactivity in different hyperprolactinemic animal models .
1943468	4	cysteamine	769,779	prolactin	677,686	cysteamine	prolactin	MESH:D003543	24683(Tax:10116)	Chemical	Gene	dose|nmod|START_ENTITY bearing|nmod|dose tumor|acl|bearing seen|nmod|tumor seen|nsubjpass|reduction reduction|nmod|levels levels|compound|END_ENTITY	However , a significant reduction in serum prolactin levels was seen in these same tumor bearing animals at only the 150 mg/kg dose of cysteamine .
3109888	0	cysteamine	14,24	prolactin	134,143	cysteamine	prolactin	MESH:D003543	24683(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY compounds|nsubj|effect compounds|nmod|levels levels|compound|END_ENTITY	The effect of cysteamine , cystamine , and the structurally related compounds taurine , N-acetyl-cysteine , and D-penicillamine on plasma prolactin levels in normal and estrogen-primed hyperprolactinemic rats .
3683075	0	cysteamine	10,20	prolactin	41,50	cysteamine	prolactin	MESH:D003543	24683(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of cysteamine on suckling-induced prolactin secretion in the rat .
2905659	0	cysteamine	86,96	somatostatin	116,128	cysteamine	somatostatin	MESH:D003543	24797(Tax:10116)	Chemical	Gene	depletion|amod|START_ENTITY depletion|nmod|END_ENTITY	Somatostatin and SMS_201-995 reverse the impairment_of_cognitive_functions induced by cysteamine depletion of brain somatostatin .
6137403	0	cysteamine	37,47	somatostatin	51,63	cysteamine	somatostatin	MESH:D003543	24797(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	The effect of the duodenal ulcerogen cysteamine on somatostatin and gastrin cells in the rat .
22024594	0	cysteine	23,31	APE1	42,46	cysteine	APE1	MESH:D003545	328	Chemical	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	S-glutathionylation of cysteine 99 in the APE1 protein impairs abasic endonuclease activity .
9321919	0	cysteine	36,44	AQP1	72,76	cysteine	AQP1	MESH:D003545	358	Chemical	Gene	Importance|nmod|START_ENTITY Importance|nmod|END_ENTITY	Importance of the mercury-sensitive cysteine on function and routing of AQP1 and AQP2 in oocytes .
16565729	0	cysteine	19,27	AT1	39,42	cysteine	AT1	MESH:D003545	185	Chemical	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	S-nitrosylation of cysteine 289 of the AT1 receptor decreases its binding affinity for angiotensin_II .
24076026	0	cysteine	12,20	AtCYSb	42,48	cysteine	AtCYSb	MESH:D003545	820428(Tax:3702)	Chemical	Gene	interacts|compound|START_ENTITY interacts|compound|END_ENTITY	Arabidopsis cysteine proteinase inhibitor AtCYSb interacts with a Ca -LRB- 2 + -RRB- - dependent nuclease , AtCaN2 .
24379391	0	cysteine	86,94	Atg4	81,85	cysteine	Atg4	MESH:D003545	855498(Tax:4932)	Chemical	Gene	proteases|compound|START_ENTITY proteases|amod|END_ENTITY	Differential processing of Arabidopsis ubiquitin-like Atg8 autophagy proteins by Atg4 cysteine proteases .
15973770	0	cysteine	30,38	CCR5	61,65	cysteine	CCR5	MESH:D003545	1234	Chemical	Gene	START_ENTITY|dobj|expression expression|compound|END_ENTITY	Extracellular HIV Tat and Tat cysteine rich peptide increase CCR5 expression in monocytes .
10897033	0	cysteine	154,162	CD98HC	174,180	cysteine	CD98HC	MESH:D003545	6520	Chemical	Gene	residue|amod|START_ENTITY residue|nmod|END_ENTITY	Transformation of BALB3T3 cells caused by over-expression of rat CD98 heavy chain -LRB- HC -RRB- requires its association with light chain : mis-sense mutation in a cysteine residue of CD98HC eliminates its transforming activity .
16339885	0	cysteine	29,37	CLIC1	20,25	cysteine	CLIC1	MESH:D003545	1192	Chemical	Gene	residues|amod|START_ENTITY END_ENTITY|nmod|residues	Redox regulation of CLIC1 by cysteine residues associated with the putative channel pore .
16155195	0	cysteine	53,61	COL2A1	79,85	cysteine	COL2A1	MESH:D003545	1280	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	The phenotypic spectrum in patients with arginine to cysteine mutations in the COL2A1 gene .
12574338	0	cysteine	24,32	CPB2	43,47	cysteine	CPB2	MESH:D003545	56373(Tax:10090)	Chemical	Gene	protease|compound|START_ENTITY protease|appos|END_ENTITY	The Leishmania mexicana cysteine protease , CPB2 .8 , induces potent Th2 responses .
21735610	0	cysteine	141,149	Caspase_1	30,39	cysteine	Caspase 1	MESH:D003545	834	Chemical	Gene	residue|compound|START_ENTITY END_ENTITY|nmod|residue	A small molecule inhibitor of Caspase_1 A nitrile-containing propionic_acid moiety as an electrophile for covalent attack by the active site cysteine residue of caspase_1 was investigated .
12437106	0	cysteine	56,64	Cathepsin_B	0,11	cysteine	Cathepsin B	MESH:D003545	1508	Chemical	Gene	affected|nmod|START_ENTITY affected|nsubjpass|stability stability|amod|END_ENTITY	Cathepsin_B stability , but not activity , is affected in cysteine : cystine redox buffers .
15265002	0	cysteine	15,23	Cathepsin_K	0,11	cysteine	Cathepsin K	MESH:D003545	1513	Chemical	Gene	protease|amod|START_ENTITY END_ENTITY|dep|protease	Cathepsin_K : a cysteine protease with unique kinin-degrading properties .
23629523	0	cysteine	37,45	Cathepsin_K	0,11	cysteine	Cathepsin K	MESH:D003545	1513	Chemical	Gene	peptidase|compound|START_ENTITY END_ENTITY|dep|peptidase	Cathepsin_K : a unique collagenolytic cysteine peptidase .
8763963	0	cysteine	145,153	CcrA	170,174	cysteine	CcrA	MESH:D003545	14014258	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Dsb-insensitive expression of CcrA , a metallo-beta-lactamase from Bacteroides_fragilis , in Escherichia_coli after amino_acid substitution at two cysteine residues within CcrA .
12765788	0	cysteine	55,63	Chrp	47,51	cysteine	Chrp	MESH:D003545	54151(Tax:10090)	Chemical	Gene	protein|amod|START_ENTITY END_ENTITY|appos|protein	Specificity of interactions of galectin-3 with Chrp , a cysteine - and histidine-rich cytoplasmic protein .
14570918	0	cysteine	69,77	CvaB	102,106	cysteine	CvaB	MESH:D003545	3853540(Tax:562)	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Cys32 and His105 are the critical residues for the calcium-dependent cysteine proteolytic activity of CvaB , an ATP-binding cassette transporter .
23747973	0	cysteine	250,258	Cysteine_dioxygenase	0,20	cysteine	Cysteine dioxygenase	MESH:D003545	1036	Chemical	Gene	conversion|nmod|START_ENTITY catalyzes|dobj|conversion protein|acl:relcl|catalyzes protein|nsubj|structures structures|amod|END_ENTITY	Cysteine_dioxygenase structures from pH4 to 9 : consistent cys-persulfenate formation at intermediate pH and a Cys-bound enzyme at higher pH. Mammalian cysteine_dioxygenase -LRB- CDO -RRB- is a mononuclear non-heme iron protein that catalyzes the conversion of cysteine -LRB- Cys -RRB- to cysteine_sulfinic_acid by an unclarified mechanism .
21481189	0	cysteine	92,100	Dnmt3a	66,72	cysteine	Dnmt3a	MESH:D003545	13435(Tax:10090)	Chemical	Gene	residue|compound|START_ENTITY END_ENTITY|nmod|residue	Auto-methylation of the mouse DNA - -LRB- cytosine C5 -RRB- - methyltransferase Dnmt3a at its active site cysteine residue .
7861176	0	cysteine	21,29	Dopamine_transporter	0,20	cysteine	Dopamine transporter	MESH:D003545	6531	Chemical	Gene	mutants|compound|START_ENTITY mutants|amod|END_ENTITY	Dopamine_transporter cysteine mutants : second extracellular loop cysteines are required for transporter expression .
23579332	0	cysteine	130,138	EAAT3	115,120	cysteine	EAAT3	MESH:D003545	6505	Chemical	Gene	uptake|compound|START_ENTITY uptake|nummod|END_ENTITY	Soluble oligomers of amyloid-b cause changes in redox state , DNA methylation , and gene transcription by inhibiting EAAT3 mediated cysteine uptake .
15706091	0	cysteine	27,35	Hsp25	54,59	cysteine	Hsp25	MESH:D003545	15507(Tax:10090)	Chemical	Gene	residue|compound|START_ENTITY residue|nmod|END_ENTITY	Substitution of the unique cysteine residue of murine Hsp25 interferes with the protective activity of this stress protein through inhibition of dimer formation .
17180094	0	cysteine	18,26	ICE	4,7	cysteine	ICE	MESH:D003545	834	Chemical	Gene	family|nmod|START_ENTITY family|compound|END_ENTITY	The ICE family of cysteine proteases as effectors of cell death .
15653693	2	cysteine	303,311	IDPm	326,330	cysteine	IDPm	MESH:D003545	3418	Chemical	Gene	residue|amod|START_ENTITY residue|nmod|END_ENTITY	Because cysteine residue -LRB- s -RRB- in IDPm are susceptible to inactivation by a number of thiol-modifying reagents , we hypothesized that IDPm is likely a target for regulation by an oxidative mechanism , specifically glutathionylation .
22693631	0	cysteine	57,65	ISG15	35,40	cysteine	ISG15	MESH:D003545	9636	Chemical	Gene	modification|nmod|START_ENTITY modification|nmod|END_ENTITY	Covalent protein modification with ISG15 via a conserved cysteine in the hinge region .
19591457	0	cysteine	95,103	IkappaB_kinase_beta	116,135	cysteine	IkappaB kinase beta	MESH:D003545	3551	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	N-tosyl-L-phenylalanine_chloromethyl_ketone inhibits NF-kappaB activation by blocking specific cysteine residues of IkappaB_kinase_beta and p65/RelA .
14585973	0	cysteine	9,17	Keap1	30,35	cysteine	Keap1	MESH:D003545	9817	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress .
19808700	0	cysteine	9,17	Kelch-like_ECH-associated_protein_1	30,65	cysteine	Kelch-like ECH-associated protein 1	MESH:D003545	50868(Tax:10090)	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	Critical cysteine residues of Kelch-like_ECH-associated_protein_1 in arsenic sensing and suppression of nuclear_factor_erythroid_2-related_factor_2 .
11279219	3	cysteine	454,462	LHX3	491,495	cysteine	Lhx3	MESH:D003545	16871(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	The mutation is predicted to lead to the replacement of a tyrosine residue with a cysteine in the second LIM domain of LHX3 .
15982782	0	cysteine	4,12	MC1R	34,38	cysteine	MC1R	MESH:D003545	4157	Chemical	Gene	substitutions|amod|START_ENTITY substitutions|nmod|END_ENTITY	Two cysteine substitutions in the MC1R generate the blue variant of the Arctic fox -LRB- Alopex lagopus -RRB- and prevent expression of the white winter coat .
17553782	0	cysteine	103,111	Mia40	157,162	cysteine	Mia40	MESH:D003545	131474	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Biogenesis of the essential Tim9-Tim10 chaperone complex of mitochondria : site-specific recognition of cysteine residues by the intermembrane space receptor Mia40 .
12213807	0	cysteine	39,47	NF-kappa_B	59,69	cysteine	NF-kappa B	MESH:D003545	4790	Chemical	Gene	residue|compound|START_ENTITY residue|nmod|END_ENTITY	Spatial redox regulation of a critical cysteine residue of NF-kappa_B in vivo .
19786557	0	cysteine	5,13	NRF2	0,4	cysteine	NRF2	MESH:D003545	4780	Chemical	Gene	residues|compound|START_ENTITY residues|compound|END_ENTITY	NRF2 cysteine residues are critical for oxidant/electrophile-sensing , Kelch-like_ECH-associated_protein-1-dependent ubiquitination-proteasomal degradation , and transcription activation .
21357422	0	cysteine	57,65	NRF2	41,45	cysteine	NRF2	MESH:D003545	4780	Chemical	Gene	mechanism|amod|START_ENTITY activate|nmod|mechanism activate|dobj|END_ENTITY	Electrophilic nitro-fatty_acids activate NRF2 by a KEAP1 cysteine 151-independent mechanism .
18656957	0	cysteine	66,74	NTPDase_2	20,29	cysteine	NTPDase 2	MESH:D003545	954	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of human NTPDase_2 by modification of an intramembrane cysteine by p-chloromercuriphenylsulfonate and oxidative cross-linking of the transmembrane domains .
11948402	0	cysteine	29,37	Nrf2	77,81	cysteine	Nrf2	MESH:D003545	4780	Chemical	Gene	START_ENTITY|acl|serine serine|nmod|region region|nmod|END_ENTITY	Site-directed mutagenesis of cysteine to serine in the DNA binding region of Nrf2 decreases its capacity to upregulate antioxidant response element-mediated expression and antioxidant induction of NAD -LRB- P -RRB- H : quinone_oxidoreductase1 gene .
14585973	0	cysteine	9,17	Nrf2	87,91	cysteine	Nrf2	MESH:D003545	4780	Chemical	Gene	residues|compound|START_ENTITY required|nsubjpass|residues required|nmod|ubiquitination ubiquitination|nmod|END_ENTITY	Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress .
18268004	0	cysteine	39,47	Nrf2	81,85	cysteine	Nrf2	MESH:D003545	18024(Tax:10090)	Chemical	Gene	START_ENTITY|advcl|determining determining|dobj|activity activity|amod|END_ENTITY	Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity .
19920073	0	cysteine	42,50	Nrf2	177,181	cysteine	Nrf2	MESH:D003545	4780	Chemical	Gene	151|compound|START_ENTITY modification|nmod|151 required|nsubjpass|modification required|nmod|translocation translocation|nmod|END_ENTITY	Antioxidant-induced modification of INrf2 cysteine 151 and PKC-delta-mediated phosphorylation of Nrf2 serine 40 are both required for stabilization and nuclear translocation of Nrf2 and increased drug resistance .
22302369	0	cysteine	60,68	Nrf2	73,77	cysteine	Nrf2	MESH:D003545	4780	Chemical	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Induction of NAD -LRB- P -RRB- H : quinone_oxidoreductase_1 expression by cysteine via Nrf2 activation in human intestinal epithelial LS180 cells .
24489685	0	cysteine	6,14	Nrf2	72,76	cysteine	Nrf2	MESH:D003545	18024(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|target target|nmod|activation activation|amod|END_ENTITY	Keap1 cysteine 288 as a potential target for diallyl_trisulfide-induced Nrf2 activation .
23058916	0	cysteine	145,153	Orai1	165,170	cysteine	Orai1	MESH:D003545	84876	Chemical	Gene	residue|amod|START_ENTITY residue|nmod|END_ENTITY	Inhibition of Ca -LRB- 2 + -RRB- release-activated Ca -LRB- 2 + -RRB- channel -LRB- CRAC -RRB- by curcumin and caffeic_acid_phenethyl_ester -LRB- CAPE -RRB- via electrophilic addition to a cysteine residue of Orai1 .
10373502	0	cysteine	15,23	RGS16	36,41	cysteine	RGS16	MESH:D003545	6004	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	Amino-terminal cysteine residues of RGS16 are required for palmitoylation and modulation of Gi - and Gq-mediated signaling .
12642593	1	cysteine	108,116	RGS16	129,134	cysteine	RGS16	MESH:D003545	360857(Tax:10116)	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	I. Mutation of amino-terminal cysteine residues on RGS16 prevents its targeting to lipid rafts and palmitoylation of an internal cysteine residue .
11535795	0	cysteine	27,35	RL3841	76,82	cysteine	RL3841	MESH:D003545	4403541(Tax:216596)	Chemical	Gene	biosynthesis|amod|START_ENTITY biosynthesis|nmod|END_ENTITY	Evidence for redundancy in cysteine biosynthesis in Rhizobium_leguminosarum RL3841 : analysis of a cysE gene encoding serine acetyltransferase .
10490816	0	cysteine	30,38	Ret	54,57	cysteine	Ret	MESH:D003545	5979	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	The Glu632-Leu633 deletion in cysteine rich domain of Ret induces constitutive dimerization and alters the processing of the receptor protein .
8910410	0	cysteine	55,63	S-adenosylhomocysteine_hydrolase	92,124	cysteine	S-adenosylhomocysteine hydrolase	MESH:D003545	191	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Chemical modification and site-directed mutagenesis of cysteine residues in human placental S-adenosylhomocysteine_hydrolase .
12297027	0	cysteine	20,28	S-adenosylmethionine_decarboxylase	82,116	cysteine	S-adenosylmethionine decarboxylase	MESH:D003545	832011(Tax:3702)	Chemical	Gene	residues|amod|START_ENTITY roles|nmod|residues roles|nmod|END_ENTITY	Structural roles of cysteine 50 and cysteine_230 residues in Arabidopsis_thaliana S-adenosylmethionine_decarboxylase .
21147769	0	cysteine	94,102	Swi6p	139,144	cysteine	Swi6p	MESH:D003545	850879(Tax:4932)	Chemical	Gene	residue|compound|START_ENTITY residue|nmod|END_ENTITY	Cell cycle sensing of oxidative stress in Saccharomyces_cerevisiae by oxidation of a specific cysteine residue in the transcription factor Swi6p .
22193716	0	cysteine	47,55	TDP-43	36,42	cysteine	TDP-43	MESH:D003545	23435	Chemical	Gene	oxidation|amod|START_ENTITY END_ENTITY|nmod|oxidation	Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linking .
24733836	0	cysteine	43,51	TM3	39,42	cysteine	TM3	MESH:D003545	7170	Chemical	Gene	mutants|compound|START_ENTITY mutants|compound|END_ENTITY	State-dependent block of Orai3 TM1 and TM3 cysteine mutants : insights into 2-APB activation .
20547845	0	cysteine	11,19	Toll-like_receptor_4	53,73	cysteine	Toll-like receptor 4	MESH:D003545	7099	Chemical	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	A critical cysteine is required for HMGB1 binding to Toll-like_receptor_4 and activation of macrophage cytokine release .
12048031	0	cysteine	24,32	Vif	49,52	cysteine	Vif	MESH:D003545	155459(Tax:11676)	Chemical	Gene	region|amod|START_ENTITY region|nmod|END_ENTITY	Subtle mutations in the cysteine region of HIV-1 Vif drastically alter the viral replication phenotype .
24444374	7	cysteine	1266,1274	Ycf1p	1287,1292	cysteine	Ccs1p	MESH:D003545	855054(Tax:4932)	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	Functional defect in Ycf1p associated with the absence of Sod1p as well as another antioxidant enzyme Glr1p is rescued by anaerobic growth or substitutions of specific cysteine residues of Ycf1p to alanine or serine .
12149129	0	cysteine	82,90	acetylcholinesterase	26,46	cysteine	acetylcholinesterase	MESH:D003545	41625(Tax:7227)	Chemical	Gene	elimination|nmod|START_ENTITY END_ENTITY|nmod|elimination	Improvement of Drosophila acetylcholinesterase stability by elimination of a free cysteine .
12801930	0	cysteine	89,97	acid_sphingomyelinase	20,41	cysteine	acid sphingomyelinase	MESH:D003545	6609	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of human acid_sphingomyelinase through modification or deletion of C-terminal cysteine .
17287397	0	cysteine	16,24	actin	10,15	cysteine	actin	MESH:D003545	850504(Tax:4932)	Chemical	Gene	residues|compound|START_ENTITY residues|compound|END_ENTITY	Conserved actin cysteine residues are oxidative stress sensors that can regulate cell death in yeast .
3730446	0	cysteine	17,25	alpha-chain	42,53	cysteine	alpha-chain	MESH:D003545	2217	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	-LSB- Localization of cysteine residues in the alpha-chain of histidine_decarboxylase from Micrococcus sp .
7532583	0	cysteine	35,43	alpha_2-macroglobulin	62,83	cysteine	alpha 2-macroglobulin	MESH:D003545	2	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Methanethiolation of the liberated cysteine residues of human alpha_2-macroglobulin treated with methylamine generates a derivative with similar functional characteristics as native alpha_2-macroglobulin .
9085244	0	cysteine	62,70	alpha_2-macroglobulin	22,43	cysteine	alpha 2-macroglobulin	MESH:D003545	2	Chemical	Gene	control|nmod|START_ENTITY END_ENTITY|nmod|control	The potential role of alpha_2-macroglobulin in the control of cysteine proteinases -LRB- gingipains -RRB- from Porphyromonas_gingivalis .
9566737	0	cysteine	47,55	aryl_sulfotransferase_IV	72,96	cysteine	aryl sulfotransferase IV	MESH:D003545	83783(Tax:10116)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	A review of the effects of manipulation of the cysteine residues of rat aryl_sulfotransferase_IV .
17327478	0	cysteine	39,47	beta_globin	27,38	cysteine	beta globin	MESH:D003545	15127(Tax:10090)	Chemical	Gene	content|compound|START_ENTITY content|compound|END_ENTITY	Genetic variation in mouse beta_globin cysteine content modifies glutathione metabolism : implications for the use of mouse models .
4337940	0	cysteine	43,51	bradykinin	20,30	cysteine	bradykinin	MESH:D003545	3827	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Potentiation of the bradykinin response by cysteine : mechanism of action .
19671797	0	cysteine	76,84	cFos	92,96	cysteine	cFos	MESH:D003545	14281(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|domain domain|amod|END_ENTITY	Inhibition of activator_protein-1 by sulforaphane involves interaction with cysteine in the cFos DNA-binding domain : implications for chemoprevention of UVB-induced skin_cancer .
15284079	4	cysteine	840,848	cPGES	866,871	cysteine	cPGES	MESH:D003545	362809(Tax:10116)	Chemical	Gene	residue|amod|START_ENTITY residue|nmod|END_ENTITY	Importantly , we found that cytosolic PGES also associates with microsomes -LRB- cPGES-m -RRB- from the cerebrum and cerebral vasculature of the pig and rat as well as microsomes from various cell lines ; this seemed dependent on the carboxyl terminal 35-amino_acid domain and a cysteine residue -LRB- C58 -RRB- of cPGES .
14751262	0	cysteine	68,76	calmodulin	84,94	cysteine	calmodulin	MESH:D003545	808	Chemical	Gene	protein|amod|START_ENTITY protein|compound|END_ENTITY	Fluorescence labeling , purification , and immobilization of a double cysteine mutant calmodulin fusion protein for single-molecule experiments .
23295225	0	cysteine	41,49	carbonyl_reductase_1	68,88	cysteine	carbonyl reductase 1	MESH:D003545	873	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	S-nitrosoglutathione covalently modifies cysteine residues of human carbonyl_reductase_1 and affects its activity .
10384960	0	cysteine	38,46	cathepsin_B	14,25	cysteine	cathepsin B	MESH:D003545	1508	Chemical	Gene	thiols|amod|START_ENTITY Regulation|nmod|thiols Regulation|nmod|activity activity|amod|END_ENTITY	Regulation of cathepsin_B activity by cysteine and related thiols .
10876156	0	cysteine	10,18	cathepsin_B	29,40	cysteine	cathepsin B	MESH:D003545	64529(Tax:10116)	Chemical	Gene	protease|compound|START_ENTITY protease|appos|END_ENTITY	Lysosomal cysteine protease , cathepsin_B , is targeted to lysosomes by the mannose_6-phosphate-independent pathway in rat hepatocytes : site-specific phosphorylation in oligosaccharides of the proregion .
11517926	0	cysteine	40,48	cathepsin_B	94,105	cysteine	cathepsin B	MESH:D003545	13030(Tax:10090)	Chemical	Gene	peptidases|compound|START_ENTITY functions|nmod|peptidases functions|dep|phenotypes phenotypes|nmod|deficient deficient|nmod|END_ENTITY	Towards specific functions of lysosomal cysteine peptidases : phenotypes of mice deficient for cathepsin_B or cathepsin_L .
12108549	5	cysteine	727,735	cathepsin_B	776,787	cysteine	cathepsin L	MESH:D003545	13039(Tax:10090)	Chemical	Gene	inhibitors|nmod|START_ENTITY proteinases|nsubj|inhibitors proteinases|parataxis|inhibited inhibited|nsubj|inhibitors inhibitors|amod|END_ENTITY	Synthetic inhibitors of cysteine proteinases markedly impaired invasion : cathepsin_B inhibitors , particularly Ca-074Me , inhibited invasion from 20-40 % , whereas cathepsin_L inhibitor Clik_148 reduced invasion by 11 % .
13678335	0	cysteine	68,76	cathepsin_B	14,25	cysteine	cathepsin B	MESH:D003545	1508	Chemical	Gene	inhibitor|amod|START_ENTITY tissue|nmod|inhibitor activity|nmod|tissue activity|amod|END_ENTITY	Inhibition of cathepsin_B activity in human breast_cancer tissue by cysteine peptidase inhibitor isolated from human placenta : immunohistochemical and biochemical studies .
1382984	0	cysteine	73,81	cathepsin_B	35,46	cysteine	cathepsin B	MESH:D003545	64529(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Effects of selective inhibition of cathepsin_B and general inhibition of cysteine proteinases on lysosomal proteolysis in rat liver in vivo and in vitro .
15367886	0	cysteine	21,29	cathepsin_B	40,51	cysteine	cathepsin B	MESH:D003545	1508	Chemical	Gene	impact|nmod|START_ENTITY proteases|nsubj|impact proteases|xcomp|END_ENTITY	Prognostic impact of cysteine proteases cathepsin_B and cathepsin_L in pancreatic_adenocarcinoma .
15897303	0	cysteine	58,66	cathepsin_B	78,89	cysteine	cathepsin B	MESH:D003545	1508	Chemical	Gene	proteases|amod|START_ENTITY Proteolysis|nmod|proteases Proteolysis|parataxis|generates generates|nsubj|END_ENTITY	Proteolysis of serum_amyloid_A and AA_amyloid_proteins by cysteine proteases : cathepsin_B generates AA_amyloid_proteins and cathepsin_L may prevent their formation .
16869297	2	cysteine	376,384	cathepsin_B	396,407	cysteine	cathepsin D	MESH:D003545	1509	Chemical	Gene	proteases|amod|START_ENTITY proteases|dep|END_ENTITY	In humans , TPP I constitutes an integral part of the lysosomal proteolytic apparatus , which , includes numerous hydrolytic enzymes , mostly cysteine proteases -LRB- cathepsin_B , C , H , K , L , and others -RRB- , but also serine -LRB- cathepsin_A -RRB- and aspartic -LRB- cathepsin_D -RRB- proteases .
18501979	0	cysteine	24,32	cathepsin_B	12,23	cysteine	cathepsin B	MESH:D003545	1508	Chemical	Gene	proteases|compound|START_ENTITY proteases|amod|END_ENTITY	A family of cathepsin_B cysteine proteases expressed in the gut of the human hookworm , Necator_americanus .
19434518	0	cysteine	63,71	cathepsin_B	33,44	cysteine	cathepsin B	MESH:D003545	1508	Chemical	Gene	cathepsins|compound|START_ENTITY not|nmod|cathepsins regulation|dep|not regulation|nmod|END_ENTITY	Post-translational regulation of cathepsin_B , but not of other cysteine cathepsins , contributes to increased glioblastoma cell invasiveness in vitro .
19807666	0	cysteine	82,90	cathepsin_B	162,173	cysteine	cathepsin B	MESH:D003545	1508	Chemical	Gene	proteases|amod|START_ENTITY probes|nmod|proteases identification|nmod|probes identification|dep|experiences experiences|nmod|Center Center|nmod|Discovery Discovery|nmod|END_ENTITY	The identification , characterization and optimization of small molecule probes of cysteine proteases : experiences of the Penn Center for Molecular Discovery with cathepsin_B and cathepsin_L .
24940640	0	cysteine	60,68	cathepsin_B	37,48	cysteine	cathepsin B	MESH:D003545	1508	Chemical	Gene	cathepsins|compound|START_ENTITY END_ENTITY|dobj|cathepsins	Prodrug-inspired probes selective to cathepsin_B over other cysteine cathepsins .
3454203	0	cysteine	26,34	cathepsin_B	48,59	cysteine	cathepsin B	MESH:D003545	1508	Chemical	Gene	proteinases|amod|START_ENTITY proteinases|appos|END_ENTITY	Activity of the lysosomal cysteine proteinases -LRB- cathepsin_B , H , L -RRB- and a metalloproteinase -LRB- MMP-7-ase -RRB- in the serum of cystic_fibrosis homozygous children .
6337648	0	cysteine	29,37	cathepsin_B	103,114	cysteine	cathepsin B	MESH:D003545	1508	Chemical	Gene	Characterization|nmod|START_ENTITY proteinase|nsubj|Characterization proteinase|nmod|form form|nmod|END_ENTITY	Characterization of a latent cysteine proteinase from ascitic fluid as a high molecular weight form of cathepsin_B .
6357015	0	cysteine	17,25	cathepsin_B	95,106	cysteine	cathepsin B	MESH:D003545	1508	Chemical	Gene	proteinase|nsubj|START_ENTITY proteinase|nmod|identification identification|nmod|END_ENTITY	Cathepsin_B-like cysteine proteinase activity in sputum and immunohistologic identification of cathepsin_B in alveolar macrophages .
6762209	0	cysteine	2,10	cathepsin_B	87,98	cysteine	cathepsin B	MESH:D003545	1508	Chemical	Gene	proteinase|amod|START_ENTITY related|nsubjpass|proteinase related|xcomp|END_ENTITY	A cysteine proteinase secreted from human breast_tumours is immunologically related to cathepsin_B .
7934617	0	cysteine	126,134	cathepsin_B	24,35	cysteine	cathepsin B	MESH:D003545	13030(Tax:10090)	Chemical	Gene	inhibitors|amod|START_ENTITY presence|nmod|inhibitors cultured|nmod|presence cultured|nsubj|activities activities|nmod|hydrolases hydrolases|compound|END_ENTITY	Increased activities of cathepsin_B and other lysosomal hydrolases in fibroblasts and bone tissue cultured in the presence of cysteine proteinases inhibitors .
8432559	0	cysteine	23,31	cathepsin_B	120,131	cysteine	cathepsin B	MESH:D003545	64529(Tax:10116)	Chemical	Gene	proteinases|compound|START_ENTITY Detection|nmod|proteinases Detection|dep|measurement measurement|nmod|END_ENTITY	Detection of lysosomal cysteine proteinases in microglia : flow cytometric measurement and histochemical localization of cathepsin_B and L .
9068283	0	cysteine	20,28	cathepsin_B	44,55	cysteine	cathepsin B	MESH:D003545	100101593(Tax:9986)	Chemical	Gene	endopeptidase|amod|START_ENTITY endopeptidase|dep|END_ENTITY	Temporal pattern of cysteine endopeptidase -LRB- cathepsin_B -RRB- expression in cartilage and synovium from rabbit knees with experimental osteoarthritis : gene expression in chondrocytes in response to interleukin-1 and matrix depletion .
9096102	0	cysteine	27,35	cathepsin_B	48,59	cysteine	cathepsin B	MESH:D003545	13030(Tax:10090)	Chemical	Gene	genes|nmod|START_ENTITY proteinases|nsubj|genes proteinases|xcomp|END_ENTITY	The genes of the lysosomal cysteine proteinases cathepsin_B , H , L , and S map to different mouse chromosomes .
9569125	0	cysteine	31,39	cathepsin_B	67,78	cysteine	cathepsin B	MESH:D003545	1508	Chemical	Gene	Participation|nmod|START_ENTITY proteinases|nsubj|Participation proteinases|nmod|END_ENTITY	Participation of intracellular cysteine proteinases , in particular cathepsin_B , in degradation of collagen in periosteal tissue explants .
7051705	1	cysteine	279,287	cathepsin_D	367,378	cysteine	cathepsin D	MESH:D003545	171293(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY activity|dep|END_ENTITY	Two methods have been developed to discriminate simultaneously between the main part of cysteine proteinase activity -LRB- cathepsin_L -RRB- and all aspartic proteinase activity -LRB- mainly cathepsin_D -RRB- in rat organs , using Z-Phe-Phe-CHN2 which at 5 mumol/l completely inhibits cathepsin_L from rat liver and , on the other hand , pepstatin which at 0.5 mumol/l completely inhibits cathepsin_D .
10353637	0	cysteine	42,50	cathepsin_K	60,71	cysteine	cathepsin K	MESH:D003545	1513	Chemical	Gene	protease|amod|START_ENTITY inhibitors|nmod|protease END_ENTITY|nsubj|inhibitors	Potent dipeptidylketone inhibitors of the cysteine protease cathepsin_K .
10961902	0	cysteine	64,72	cathepsin_K	108,119	cysteine	cathepsin K	MESH:D003545	1513	Chemical	Gene	proteinases|amod|START_ENTITY proteinases|nmod|END_ENTITY	Pathologic gene expression in Gaucher_disease : up-regulation of cysteine proteinases including osteoclastic cathepsin_K .
11262083	0	cysteine	32,40	cathepsin_K	50,61	cysteine	cathepsin K	MESH:D003545	1513	Chemical	Gene	protease|amod|START_ENTITY inhibitors|nmod|protease END_ENTITY|nsubj|inhibitors	Cyclic_ketone inhibitors of the cysteine protease cathepsin_K .
11743044	0	cysteine	31,39	cathepsin_K	51,62	cysteine	cathepsin K	MESH:D003545	1513	Chemical	Gene	proteinase|compound|START_ENTITY Expression|nmod|proteinase END_ENTITY|nsubj|Expression	Expression of matrix-degrading cysteine proteinase cathepsin_K in cholesteatoma .
17935329	0	cysteine	61,69	cathepsin_K	112,123	cysteine	cathepsin K	MESH:D003545	1513	Chemical	Gene	protease|amod|START_ENTITY pathway|nmod|protease simulations|nmod|pathway simulations|dep|study study|nmod|END_ENTITY	Molecular dynamics simulations of the catalytic pathway of a cysteine protease : a combined QM/MM study of human cathepsin_K .
25184245	0	cysteine	47,55	cathepsin_K	66,77	cysteine	cathepsin K	MESH:D003545	1513	Chemical	Gene	peptidase|amod|START_ENTITY space|nmod|peptidase Probing|dobj|space END_ENTITY|csubj|Probing	Probing the activity modification space of the cysteine peptidase cathepsin_K with novel allosteric modifiers .
7818555	0	cysteine	55,63	cathepsin_K	36,47	cysteine	cathepsin K	MESH:D003545	1513	Chemical	Gene	proteinase|compound|START_ENTITY cloning|dep|proteinase cloning|nmod|cDNA cDNA|nmod|END_ENTITY	Molecular cloning of human cDNA for cathepsin_K : novel cysteine proteinase predominantly expressed in bone .
9538271	0	cysteine	86,94	cathepsin_K	42,53	cysteine	cathepsin K	MESH:D003545	13038(Tax:10090)	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Fluorescence microscopic demonstration of cathepsin_K activity as the major lysosomal cysteine proteinase in osteoclasts .
10653162	0	cysteine	76,84	cathepsin_P	40,51	cysteine	cathepsin P	MESH:D003545	1522	Chemical	Gene	START_ENTITY|nsubj|cloning cloning|nmod|END_ENTITY	Identification and molecular cloning of cathepsin_P , a novel human putative cysteine protease of the papain family .
15369380	0	cysteine	43,51	cathepsin_S	61,72	cysteine	cathepsin S	MESH:D003545	101083283	Chemical	Gene	protease|amod|START_ENTITY inhibitors|nmod|protease END_ENTITY|nsubj|inhibitors	Nonpeptidic , noncovalent inhibitors of the cysteine protease cathepsin_S .
17453790	0	cysteine	25,33	cathepsin_S	13,24	cysteine	cathepsin S	MESH:D003545	1520	Chemical	Gene	START_ENTITY|nsubj|Detection Detection|nmod|END_ENTITY	Detection of cathepsin_S cysteine protease in human brain_tumour microdialysates in vivo .
7717452	0	cysteine	14,22	cathepsin_S	33,44	cysteine	cathepsin S	MESH:D003545	1520	Chemical	Gene	protease|compound|START_ENTITY protease|appos|END_ENTITY	The lysosomal cysteine protease , cathepsin_S , is increased in Alzheimer 's _ disease and Down_syndrome_brain .
10504234	0	cysteine	21,29	cathepsin_X	6,17	cysteine	cathepsin X	MESH:D003545	1522	Chemical	Gene	protease|amod|START_ENTITY END_ENTITY|dep|protease	Human cathepsin_X : A cysteine protease with unique carboxypeptidase activity .
20727192	0	cysteine	24,32	cathepsins	33,43	cysteine	cathepsins	MESH:D003545	425657(Tax:9031)	Chemical	Gene	expression|nmod|START_ENTITY END_ENTITY|nsubj|expression	Increased expression of cysteine cathepsins in ovarian tissue from chickens with ovarian_cancer .
1801723	0	cysteine	50,58	cathepsins_B_and_L	72,90	cysteine	cathepsins B and L	MESH:D003545	64529;25697	Chemical	Gene	proteinases|amod|START_ENTITY proteinases|appos|END_ENTITY	Degradation of cartilage matrix components by the cysteine proteinases , cathepsins_B_and_L .
22797939	0	cysteine	19,27	cx37	38,42	cysteine	cx37	MESH:D003545	25655(Tax:10116)	Chemical	Gene	mutant|compound|START_ENTITY mutant|nmod|END_ENTITY	Extracellular loop cysteine mutant of cx37 fails to suppress proliferation of rat_insulinoma cells .
16953589	0	cysteine	83,91	cystathionine_beta-synthase	38,65	cysteine	cystathionine beta-synthase	MESH:D003545	875	Chemical	Gene	431|amod|START_ENTITY role|nmod|431 cysteines|dep|role cysteines|nmod|END_ENTITY	Solvent-accessible cysteines in human cystathionine_beta-synthase : crucial role of cysteine 431 in S-adenosyl-L-methionine binding .
7562113	0	cysteine	10,18	cystathionine_beta-synthase	36,63	cysteine	cystathionine beta-synthase	MESH:D003545	24250(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of cysteine on expression of cystathionine_beta-synthase in the rat liver .
8515049	0	cysteine	81,89	cystatin-beta	112,125	cysteine	cystatin-beta	MESH:D003545	25308(Tax:10116)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Lysosomal cysteine and aspartic proteinases , acid phosphatase , and an endogenous cysteine proteinase inhibitor , cystatin-beta , in rat osteoclasts .
11514663	0	cysteine	19,27	cystatin_B	64,74	cysteine	cystatin B	MESH:D003545	1476	Chemical	Gene	residue|compound|START_ENTITY Role|nmod|residue Role|nmod|END_ENTITY	Role of the single cysteine residue , Cys 3 , of human and bovine cystatin_B -LRB- stefin_B -RRB- in the inhibition of cysteine proteinases .
6203523	0	cysteine	56,64	cystatin_C	32,42	cysteine	cystatin C	MESH:D003545	1471	Chemical	Gene	inhibitors|amod|START_ENTITY END_ENTITY|nmod|inhibitors	The place of human gamma-trace -LRB- cystatin_C -RRB- amongst the cysteine proteinase inhibitors .
3436950	0	cysteine	57,65	cystatin_S	133,143	cysteine	cystatin S	MESH:D003545	1472	Chemical	Gene	inhibitor|compound|START_ENTITY sequence|nmod|inhibitor sequence|amod|related related|nmod|END_ENTITY	Characterization and amino_acid sequence of a new acidic cysteine proteinase inhibitor -LRB- cystatin_SA -RRB- structurally closely related to cystatin_S , from human whole saliva .
3514272	0	cysteine	26,34	cystatin_S	122,132	cysteine	cystatin S	MESH:D003545	1472	Chemical	Gene	Characterization|nmod|START_ENTITY proteinase|nsubj|Characterization proteinase|dobj|inhibitor inhibitor|nmod|saliva saliva|acl:relcl|related related|nmod|END_ENTITY	Characterization of a new cysteine proteinase inhibitor of human saliva , cystatin_SN , which is immunologically related to cystatin_S .
8862019	0	cysteine	76,84	cystatin_S	106,116	cysteine	cystatin S	MESH:D003545	296234(Tax:10116)	Chemical	Gene	proteinase|amod|START_ENTITY END_ENTITY|amod|proteinase	Growth inhibition of a human oral bacterium Porphyromonas_gingivalis by rat cysteine proteinase inhibitor cystatin_S .
9447264	0	cysteine	67,75	cystatin_S	103,113	cysteine	cystatin S	MESH:D003545	296234(Tax:10116)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Effect of sympathectomy on isoproterenol-induced expression of the cysteine proteinase inhibitor gene , cystatin_S , in rat submandibular glands .
14972351	0	cysteine	100,108	cysteine_dioxygenase	14,34	cysteine	cysteine dioxygenase	MESH:D003545	81718(Tax:10116)	Chemical	Gene	level|compound|START_ENTITY associated|nmod|level associated|nsubjpass|Regulation Regulation|nmod|END_ENTITY	Regulation of cysteine_dioxygenase and gamma-glutamylcysteine_synthetase is associated with hepatic cysteine level .
17327371	0	cysteine	61,69	cysteine_dioxygenase	18,38	cysteine	cysteine dioxygenase	MESH:D003545	1036	Chemical	Gene	reduces|dobj|START_ENTITY reduces|nsubj|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of cysteine_dioxygenase reduces intracellular cysteine and glutathione pools in HepG2/C3A cells .
21693692	0	cysteine	142,150	cysteine_dioxygenase	23,43	cysteine	cysteine dioxygenase	MESH:D003545	12583(Tax:10090)	Chemical	Gene	taurine|nmod|START_ENTITY synthesize|dobj|taurine END_ENTITY|advcl|synthesize	Knockout of the murine cysteine_dioxygenase gene results in severe impairment in ability to synthesize taurine and an increased catabolism of cysteine to hydrogen_sulfide .
24609271	0	cysteine	74,82	cysteine_dioxygenase	38,58	cysteine	cysteine dioxygenase	MESH:D003545	12583(Tax:10090)	Chemical	Gene	concentrations|compound|START_ENTITY show|dobj|concentrations show|nsubj|hepatocytes hepatocytes|nmod|mice mice|acl|lacking lacking|dobj|END_ENTITY	Primary hepatocytes from mice lacking cysteine_dioxygenase show increased cysteine concentrations and higher rates of metabolism of cysteine to hydrogen_sulfide and thiosulfate .
3697365	0	cysteine	24,32	cytochrome_P-450scc	45,64	cysteine	cytochrome P-450scc	MESH:D003545	338048(Tax:9913)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Characterization of two cysteine residues in cytochrome_P-450scc : chemical identification of the heme-binding cysteine residue .
12498886	0	cysteine	91,99	dexras1	71,78	cysteine	dexras1	MESH:D003545	51655	Chemical	Gene	residue|compound|START_ENTITY END_ENTITY|nmod|residue	Nitrosopeptide mapping : a novel methodology reveals s-nitrosylation of dexras1 on a single cysteine residue .
8282723	0	cysteine	56,64	dihydrofolate_reductase	18,41	cysteine	dihydrofolate reductase	MESH:D003545	1719	Chemical	Gene	residue|compound|START_ENTITY END_ENTITY|nmod|residue	Immobilization of dihydrofolate_reductase by engineered cysteine residue attached to its C-terminal end .
936210	0	cysteine	75,83	dopamine-beta-hydroxylase	46,71	cysteine	dopamine-beta-hydroxylase	MESH:D003545	1621	Chemical	Gene	studies|nmod|START_ENTITY studies|nmod|END_ENTITY	Further studies on irreversible inhibition of dopamine-beta-hydroxylase by cysteine .
938576	0	cysteine	56,64	dopamine-beta-hydroxylase	27,52	cysteine	dopamine-beta-hydroxylase	MESH:D003545	1621	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Irreversible inhibition of dopamine-beta-hydroxylase by cysteine .
940232	0	cysteine	65,73	dopamine-beta-hydroxylase	36,61	cysteine	dopamine-beta-hydroxylase	MESH:D003545	1621	Chemical	Gene	patterns|nmod|START_ENTITY patterns|nmod|END_ENTITY	Different patterns of inhibition of dopamine-beta-hydroxylase by cysteine .
7903528	0	cysteine	61,69	endo-oligopeptidase_A	96,117	cysteine	endo-oligopeptidase A	MESH:D003545	81565	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	Dynorphin-derived peptides reveal the presence of a critical cysteine for the activity of brain endo-oligopeptidase_A .
11425803	0	cysteine	12,20	fucosyltransferase_VII	39,61	cysteine	fucosyltransferase VII	MESH:D003545	2529	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	Neighboring cysteine residues in human fucosyltransferase_VII are engaged in disulfide bridges , forming small loop structures .
10208872	0	cysteine	4,12	gastric_lipase	43,57	cysteine	gastric lipase	MESH:D003545	8513	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	The cysteine residues of recombinant human gastric_lipase .
19463820	0	cysteine	21,29	hGBP1	44,49	cysteine	hGBP1	MESH:D003545	2633	Chemical	Gene	reactivity|amod|START_ENTITY reactivity|nmod|END_ENTITY	Nucleotide dependent cysteine reactivity of hGBP1 uncovers a domain movement during GTP hydrolysis .
17287197	0	cysteine	33,41	hOCT2	70,75	cysteine	hOCT2	MESH:D003545	6582	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Inorganic mercury interacts with cysteine residues -LRB- C451 and C474 -RRB- of hOCT2 to reduce its transport activity .
22923613	0	cysteine	8,16	heme_oxygenase-2	51,67	cysteine	heme oxygenase-2	MESH:D003545	3163	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Role of cysteine residues in heme binding to human heme_oxygenase-2 elucidated by two-dimensional NMR spectroscopy .
8093054	0	cysteine	24,32	insulin_receptor	52,68	cysteine	insulin receptor	MESH:D003545	3643	Chemical	Gene	region|amod|START_ENTITY region|nmod|END_ENTITY	Leu 193 mutation in the cysteine rich region of the insulin_receptor inhibits the cleavage of the insulin_receptor precursor but not insulin binding .
8349646	0	cysteine	36,44	iron-responsive_element-binding_protein	67,106	cysteine	iron-responsive element-binding protein	MESH:D003545	48	Chemical	Gene	residue|compound|START_ENTITY residue|nmod|END_ENTITY	Modification of a free Fe-S cluster cysteine residue in the active iron-responsive_element-binding_protein prevents RNA binding .
9022000	0	cysteine	99,107	lck	90,93	cysteine	lck	MESH:D003545	313050(Tax:10116)	Chemical	Gene	residues|amod|START_ENTITY END_ENTITY|nmod|residues	The cytoplasmic domain of rat NKR-P1 receptor interacts with the N-terminal domain of p56 -LRB- lck -RRB- via cysteine residues .
15459764	0	cysteine	55,63	low-density_lipoprotein_receptor	102,134	cysteine	low-density lipoprotein receptor	MESH:D003545	100689399	Chemical	Gene	binding|nmod|START_ENTITY binding|nmod|END_ENTITY	The important role for betaVLDLs binding at the fourth cysteine of first ligand-binding domain in the low-density_lipoprotein_receptor .
18502749	0	cysteine	17,25	macrophage_migration_inhibitory_factor	40,78	cysteine	macrophage migration inhibitory factor	MESH:D003545	4282	Chemical	Gene	residue|amod|START_ENTITY residue|nmod|END_ENTITY	Critical role of cysteine residue 81 of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- in MIF-induced inhibition of p53 activity .
7275987	0	cysteine	31,39	malate_dehydrogenase	92,112	cysteine	malate dehydrogenase	MESH:D003545	4200	Chemical	Gene	residue|compound|START_ENTITY residue|nmod|END_ENTITY	The N-ethylmaleimide-sensitive cysteine residue in the pH-dependent subunit interactions of malate_dehydrogenase .
19486005	0	cysteine	11,19	monoacylglycerol_lipase	31,54	cysteine	monoacylglycerol lipase	MESH:D003545	29254(Tax:10116)	Chemical	Gene	residue|compound|START_ENTITY residue|nmod|END_ENTITY	A critical cysteine residue in monoacylglycerol_lipase is targeted by a new class of isothiazolinone-based enzyme inhibitors .
22593584	0	cysteine	31,39	nicotinic_acetylcholine_receptor	58,90	cysteine	nicotinic acetylcholine receptor	MESH:D003545	1137	Chemical	Gene	residue|compound|START_ENTITY residue|nmod|END_ENTITY	A highly conserved cytoplasmic cysteine residue in the a4 nicotinic_acetylcholine_receptor is palmitoylated and regulates protein expression .
19587037	0	cysteine	61,69	nsp2	56,60	cysteine	nsp2	MESH:D003545	6253	Chemical	Gene	domain|compound|START_ENTITY domain|amod|END_ENTITY	The porcine_reproductive_and_respiratory_syndrome_virus nsp2 cysteine protease domain possesses both trans - and cis-cleavage activities .
19808700	0	cysteine	9,17	nuclear_factor_erythroid_2-related_factor_2	104,147	cysteine	nuclear factor erythroid 2-related factor 2	MESH:D003545	18024(Tax:10090)	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	Critical cysteine residues of Kelch-like_ECH-associated_protein_1 in arsenic sensing and suppression of nuclear_factor_erythroid_2-related_factor_2 .
25271160	0	cysteine	23,31	odorant_co-receptor	55,74	cysteine	odorant co-receptor	MESH:D003545	40650(Tax:7227)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Mutational analysis of cysteine residues of the insect odorant_co-receptor -LRB- Orco -RRB- from Drosophila_melanogaster reveals differential effects on agonist - and odorant-tuning receptor-dependent activation .
22240153	0	cysteine	58,66	p47phox	79,86	cysteine	p47phox	MESH:D003545	653361	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Trimer hydroxylated_quinone derived from apocynin targets cysteine residues of p47phox preventing the activation of human vascular NADPH oxidase .
19681600	0	cysteine	39,47	p53	69,72	cysteine	p53	MESH:D003545	7157	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Effect of thioredoxin deletion and p53 cysteine replacement on human p53 activity in wild-type and thioredoxin_reductase null yeast .
22065587	0	cysteine	32,40	p65	47,50	cysteine	p65	MESH:D003545	5970	Chemical	Gene	START_ENTITY|nmod|protein protein|amod|END_ENTITY	3-Formylchromone interacts with cysteine 38 in p65 protein and with cysteine 179 in IkBa kinase , leading to down-regulation of nuclear factor-kB -LRB- NF-kB -RRB- - regulated gene products and sensitization of tumor cells .
10601364	0	cysteine	4,12	p_1	67,70	cysteine	p 1	MESH:D003545	22673(Tax:10090)	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	The cysteine protease activity of the major dust mite allergen Der p_1 selectively enhances the immunoglobulin E antibody response .
16668713	0	cysteine	8,16	phosphoenolpyruvate_carboxylase	66,97	cysteine	phosphoenolpyruvate carboxylase	MESH:D003545	100101511(Tax:4577)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of cysteine in activation and allosteric regulation of maize phosphoenolpyruvate_carboxylase .
10514487	0	cysteine	39,47	phospholipase_D1	19,35	cysteine	phospholipase D1	MESH:D003545	5337	Chemical	Gene	residues|amod|START_ENTITY END_ENTITY|nmod|residues	Fatty acylation of phospholipase_D1 on cysteine residues 240 and 241 determines localization on intracellular membranes .
20948967	0	cysteine	54,62	proinsulin	43,53	cysteine	proinsulin	MESH:D003545	3630	Chemical	Gene	residues|compound|START_ENTITY residues|compound|END_ENTITY	Mutant INS-gene induced diabetes_of_youth : proinsulin cysteine residues impose dominant-negative inhibition on wild-type proinsulin transport .
11077264	0	cysteine	68,76	proteinase	77,87	cysteine	proteinase	MESH:D003545	100616101	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Evidence for a recent mutation giving rise to a truncated copy of a cysteine proteinase gene in Leishmania pifanoi .
2400574	0	cysteine	13,21	proteinase	70,80	cysteine	proteinase	MESH:D003545	100616101	Chemical	Gene	proteinase|amod|START_ENTITY Synthesis|nmod|proteinase inhibitors|nsubj|Synthesis inhibitors|advcl|END_ENTITY	Synthesis of cysteine proteinase inhibitors structurally based on the proteinase interacting N-terminal region of human cystatin_C .
8057374	0	cysteine	39,47	proteinase	48,58	cysteine	proteinase	MESH:D003545	100616101	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Characterization of a Plasmodium_vivax cysteine proteinase gene identifies uniquely conserved amino_acids that may mediate the substrate specificity of malarial hemoglobinases .
8132548	0	cysteine	31,39	pyridoxal_phosphatase	51,72	cysteine	pyridoxal phosphatase	MESH:D003545	57026	Chemical	Gene	residue|compound|START_ENTITY residue|nmod|END_ENTITY	Identification of an essential cysteine residue in pyridoxal_phosphatase from human erythrocytes .
20832396	0	cysteine	88,96	sV23	119,123	cysteine	sV23	MESH:D003545	33827(Tax:7227)	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Drosophila vitelline membrane assembly : a critical role for an evolutionarily conserved cysteine in the `` VM domain '' of sV23 .
9210480	0	cysteine	37,45	secretin_receptor	62,79	cysteine	secretin receptor	MESH:D003545	81779(Tax:10116)	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	Mutational analysis of extracellular cysteine residues of rat secretin_receptor shows that disulfide bridges are essential for receptor function .
7032910	0	cysteine	72,80	sorbitol_dehydrogenase	14,36	cysteine	sorbitol dehydrogenase	MESH:D003545	6652	Chemical	Gene	residue|compound|START_ENTITY END_ENTITY|nmod|residue	Properties of sorbitol_dehydrogenase and characterization of a reactive cysteine residue reveal unexpected similarities to alcohol dehydrogenases .
7943179	0	cysteine	37,45	stefin_A	28,36	cysteine	stefin A	MESH:D003545	209294(Tax:10090)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Increased expression of the stefin_A cysteine proteinase inhibitor occurs in the myelomonocytic cell-infiltrated tissues of autoimmune motheaten mice .
12003570	0	cysteine	65,73	syn	34,37	cysteine	syn	MESH:D003545	23336	Chemical	Gene	START_ENTITY|nsubj|synthesis synthesis|nmod|END_ENTITY	A general asymmetric synthesis of syn - and anti-beta-substituted cysteine and serine derivatives .
25130747	0	cysteine	76,84	thioredoxin	97,108	cysteine	thioredoxin	MESH:D003545	7295	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Diallyl_trisulfide induces apoptosis in Jurkat cells by the modification of cysteine residues in thioredoxin .
26169724	0	cysteine	24,32	thioredoxin	45,56	cysteine	thioredoxin	MESH:D003545	7295	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	Oxidation of structural cysteine residues in thioredoxin 1 by aromatic arsenicals enhances cancer cell cytotoxicity caused by the inhibition of thioredoxin_reductase 1 .
15063314	0	cysteine	16,24	transthyretin	36,49	cysteine	transthyretin	MESH:D003545	7276	Chemical	Gene	residue|amod|START_ENTITY residue|nmod|END_ENTITY	Modification of cysteine residue in transthyretin and a synthetic peptide : analyses by electrospray ionization mass spectrometry .
2110899	0	cysteine	75,83	tyrosinase	24,34	cysteine	tyrosinase	MESH:D003545	22173(Tax:10090)	Chemical	Gene	causing|dobj|START_ENTITY mouse|acl|causing gene|nmod|mouse gene|amod|END_ENTITY	A point mutation in the tyrosinase gene of BALB/c albino mouse causing the cysteine -- serine substitution at position 85 .
2124349	0	cysteine	10,18	tyrosinase	41,51	cysteine	tyrosinase	MESH:D003545	22173(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mutation mutation|nmod|END_ENTITY	Conserved cysteine to serine mutation in tyrosinase is responsible for the classical albino mutation in laboratory mice .
6203305	0	cysteine	36,44	tyrosinase	22,32	cysteine	tyrosinase	MESH:D003545	7299	Chemical	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of human tyrosinase by cysteine .
9498746	0	cysteine	98,106	tyrosinase	72,82	cysteine	tyrosinase	MESH:D003545	7299	Chemical	Gene	residues|amod|START_ENTITY containing|dobj|residues containing|dep|epitope epitope|nmod|END_ENTITY	Human melanoma patients recognize an HLA-A1-restricted CTL epitope from tyrosinase containing two cysteine residues : implications for tumor vaccine development .
1702992	0	cysteine-949	40,52	alpha_2-macroglobulin	71,92	cysteine-949	alpha 2-macroglobulin	null	2	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Separation and localization of the four cysteine-949 residues in human alpha_2-macroglobulin using fluorescence energy transfer .
15501044	0	cysteine_195	79,91	S-adenosylhomocysteine_hydrolase	22,54	cysteine 195	S-adenosylhomocysteine hydrolase	null	191	Chemical	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of human S-adenosylhomocysteine_hydrolase by covalent labeling of cysteine_195 with thionucleoside derivatives .
19726683	0	cysteines	17,26	GPIHBP1	52,59	cysteines	GPIHBP1	null	68453(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Highly conserved cysteines within the Ly6 domain of GPIHBP1 are crucial for the binding of lipoprotein_lipase .
16006525	0	cysteines	19,28	Keap1	63,68	cysteines	Keap1	null	9817	Chemical	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2 .
19726683	0	cysteines	17,26	Ly6	38,41	cysteines	Ly6	null	17062(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|domain domain|amod|END_ENTITY	Highly conserved cysteines within the Ly6 domain of GPIHBP1 are crucial for the binding of lipoprotein_lipase .
23446849	0	cysteines	54,63	Toll-like_receptor_7	19,39	cysteines	Toll-like receptor 7	null	51284	Chemical	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	Essential role for Toll-like_receptor_7 -LRB- TLR7 -RRB- - unique cysteines in an intramolecular disulfide bond , proteolytic cleavage and RNA sensing .
2040605	0	cysteines	15,24	estrogen_receptor	68,85	cysteines	estrogen receptor	null	2099	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Mutagenesis of cysteines in the hormone binding domain of the human estrogen_receptor .
7702578	0	cysteines	57,66	insulin_receptor	74,90	cysteines	insulin receptor	null	3643	Chemical	Gene	analysis|nmod|START_ENTITY analysis|nmod|END_ENTITY	Mutagenic structure/function analysis of the cytoplasmic cysteines of the insulin_receptor .
26216883	0	cysteines	32,41	keratin_14	45,55	cysteines	keratin 14	null	3861	Chemical	Gene	roles|nmod|START_ENTITY roles|nmod|END_ENTITY	Complementary roles of specific cysteines in keratin_14 towards the assembly , organization , and dynamics of intermediate filaments in skin keratinocytes .
23525969	0	cysteines	12,21	norepinephrine_transporter	43,69	cysteines	norepinephrine transporter	null	6530	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of cysteines and histidins of the norepinephrine_transporter .
20878668	0	cysteines	46,55	p53	24,27	cysteines	p53	null	7157	Chemical	Gene	Stabilization|nmod|START_ENTITY Stabilization|nmod|END_ENTITY	Stabilization of mutant p53 via alkylation of cysteines and effects on DNA binding .
1492127	0	cysteines	13,22	rhodopsin	84,93	cysteines	rhodopsin	null	509933(Tax:9913)	Chemical	Gene	labeled|dobj|START_ENTITY labeled|nmod|END_ENTITY	Spin labeled cysteines as sensors for protein-lipid interaction and conformation in rhodopsin .
8770906	0	cysteines	41,50	thyrotropin-releasing_hormone_receptor	86,124	cysteines	thyrotropin-releasing hormone receptor	null	7201	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A disulfide bonding interaction role for cysteines in the extracellular domain of the thyrotropin-releasing_hormone_receptor .
10620340	0	cysteinyl	90,99	CXCR4	59,64	cysteinyl	CXCR4	CHEBI:23511	7852	Chemical	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Expression and functional characterization of mutant human CXCR4 in insect cells : role of cysteinyl and negatively charged residues in ligand binding .
23505108	0	cysteinyl	32,41	CysLT1R	64,71	cysteinyl	CysLT1R	CHEBI:23511	58861(Tax:10090)	Chemical	Gene	receptors|amod|START_ENTITY receptors|dep|END_ENTITY	-LSB- Expression and distribution of cysteinyl leukotriene receptors CysLT1R and CysLT2R , and GPR17 in brain of Parkinson_disease model mice -RSB- .
17409163	0	cysteinyl	26,35	E1_and_E2	66,75	cysteinyl	E1 and E2	CHEBI:23511	6044	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Location and role of free cysteinyl residues in the Sindbis_virus E1_and_E2 glycoproteins .
17404310	0	cysteinyl	18,27	IFN-gamma	0,9	cysteinyl	IFN-gamma	CHEBI:23511	3458	Chemical	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	IFN-gamma induces cysteinyl leukotriene receptor 2 expression and enhances the responsiveness of human endothelial cells to cysteinyl_leukotrienes .
12682264	0	cysteinyl	17,26	IL-13	53,58	cysteinyl	IL-13	CHEBI:23511	3596	Chemical	Gene	receptor|amod|START_ENTITY receptor|nmod|END_ENTITY	Up-regulation of cysteinyl leukotriene 1 receptor by IL-13 enables human lung fibroblasts to respond to leukotriene_C4 and produce eotaxin .
7410419	0	cysteinyl	14,23	lipophilin	36,46	cysteinyl	lipophilin	CHEBI:23511	5354	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Nature of the cysteinyl residues in lipophilin from human myelin .
3497920	0	cysteinyl	85,94	myosin	106,112	cysteinyl	myosin	CHEBI:23511	79784	Chemical	Gene	residue|compound|START_ENTITY residue|nmod|END_ENTITY	F-actin-binding synthetic heptapeptide having the amino_acid sequence around the SH1 cysteinyl residue of myosin .
19563769	0	cysteinyl	57,66	prolyl_hydroxylase_domain_2	79,106	cysteinyl	prolyl hydroxylase domain 2	CHEBI:23511	54583	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Use of mass spectrometry to probe the nucleophilicity of cysteinyl residues of prolyl_hydroxylase_domain_2 .
15142551	0	cysteinyl	145,154	proteinase	155,165	cysteinyl	proteinase	CHEBI:23511	100616101	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|compound|END_ENTITY	Functionalised 2,3-dimethyl-3-aminotetrahydrofuran-4-one and N - -LRB- 3-oxo-hexahydrocyclopenta -LSB- b -RSB- furan-3a-yl -RRB- acylamide based scaffolds : synthesis and cysteinyl proteinase inhibition .
15465346	0	cysteinyl	128,137	proteinase	138,148	cysteinyl	proteinase	CHEBI:23511	100616101	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|compound|END_ENTITY	Bicyclic peptidomimetic tetrahydrofuro -LSB- 3,2-b -RSB- pyrrol-3-one and hexahydrofuro -LSB- 3,2-b -RSB- pyridine-3-one based scaffolds : synthesis and cysteinyl proteinase inhibition .
711738	0	cysteinyl	12,21	rhodanese	46,55	cysteinyl	rhodanese	CHEBI:23511	280946(Tax:9913)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Active site cysteinyl and arginyl residues of rhodanese .
24390153	0	cysteinyl-glycine	17,34	catechol-O-methyltransferase	75,103	cysteinyl-glycine	catechol-O-methyltransferase	MESH:C028505	1312	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|amod|END_ENTITY	Levodopa-related cysteinyl-glycine and cysteine reduction with and without catechol-O-methyltransferase inhibition in Parkinson 's _ disease patients .
19309765	0	cysteinyl_leukotriene	43,64	CysLT1	75,81	cysteinyl leukotriene	CysLT1	MESH:C112381	10800	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Quantification of montelukast , a selective cysteinyl_leukotriene receptor -LRB- CysLT1 -RRB- antagonist in human plasma by liquid chromatography-mass spectrometry : validation and its application to a human pharmacokinetic study .
17272825	0	cysteinyl_leukotriene	25,46	IL-4	70,74	cysteinyl leukotriene	IL-4	MESH:C112381	3565	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Concordant modulation of cysteinyl_leukotriene receptor expression by IL-4 and IFN-gamma on peripheral immune cells .
11046055	0	cysteinyl_leukotriene	18,39	IL-5	0,4	cysteinyl leukotriene	IL-5	MESH:C112381	3567	Chemical	Gene	START_ENTITY|nsubj|up-regulates up-regulates|compound|END_ENTITY	IL-5 up-regulates cysteinyl_leukotriene 1 receptor expression in HL-60 cells differentiated into eosinophils .
23124570	0	cysteinyl_leukotriene	147,168	cysLT1	179,185	cysteinyl leukotriene	cysLT1	MESH:C112381	10800	Chemical	Gene	receptor|amod|START_ENTITY receptor|dep|END_ENTITY	Preparation of benzo -LSB- b -RSB- furans having five-membered heterocycles at the 2-position and 2 - -LRB- 4-Alkylcarbamoylbuta-1 ,3 - dienyl -RRB- benzo -LSB- b -RSB- furans , and their cysteinyl_leukotriene receptor -LRB- cysLT1 , cysLT2 -RRB- inhibitory activity .
11854273	0	cysteinyl_leukotriene	26,47	mCysLT1	58,65	cysteinyl leukotriene	mCysLT1	MESH:C112381	58861(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Characterization of mouse cysteinyl_leukotriene receptors mCysLT1 and mCysLT2 : differential pharmacological properties and tissue distribution .
23330796	0	cysteinyl_leukotrienes	65,87	LL-37	26,31	cysteinyl leukotrienes	LL-37	null	820	Chemical	Gene	synthesis|nmod|START_ENTITY induces|dobj|synthesis induces|nsubj|END_ENTITY	The antimicrobial peptide LL-37 induces synthesis and release of cysteinyl_leukotrienes from human eosinophils -- implications for asthma .
18411412	0	cystemustine	84,96	O6-alkylguanine-DNA_alkyltransferase	6,42	cystemustine	O6-alkylguanine-DNA alkyltransferase	MESH:C051263	17314(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	A new O6-alkylguanine-DNA_alkyltransferase inhibitor associated with a nitrosourea -LRB- cystemustine -RRB- validates a strategy of melanoma-targeted therapy in murine B16 and human-resistant M4Beu melanoma xenograft models .
15703293	0	cystine	67,74	Bursicon	0,8	cystine	Bursicon	MESH:D003553	42560(Tax:7227)	Chemical	Gene	protein|amod|START_ENTITY protein|nsubj|END_ENTITY	Bursicon , the insect cuticle-hardening hormone , is a heterodimeric cystine knot protein that activates G protein-coupled receptor LGR2 .
9830050	0	cystine	46,53	NBAT	67,71	cystine	NBAT	MESH:D003553	6519	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Progressive C-terminal deletions of the renal cystine transporter , NBAT , reveal a novel bimodal pattern of functional expression .
6007221	0	cystine	36,43	aminopeptidase	44,58	cystine	aminopeptidase	MESH:D003553	10404	Chemical	Gene	START_ENTITY|dobj|activity activity|amod|END_ENTITY	-LSB- Study of hormonal effects on serum cystine aminopeptidase activity and intraplacental cystine aminopeptidase -RSB- .
6007221	0	cystine	87,94	aminopeptidase	95,109	cystine	aminopeptidase	MESH:D003553	10404	Chemical	Gene	-RSB-|amod|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Study of hormonal effects on serum cystine aminopeptidase activity and intraplacental cystine aminopeptidase -RSB- .
6638622	0	cystine	10,17	aminopeptidase	18,32	cystine	aminopeptidase	MESH:D003553	10404	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	-LSB- Assay of cystine aminopeptidase activity on a centrifuge analyser -RSB- .
7285367	0	cystine	53,60	aminopeptidase	61,75	cystine	aminopeptidase	MESH:D003553	10404	Chemical	Gene	determination|nmod|START_ENTITY END_ENTITY|nsubj|determination	A new fluorometric ultramicro determination of serum cystine aminopeptidase using an aminocoumarine derivative .
924762	0	cystine	6,13	aminopeptidase	14,28	cystine	aminopeptidase	MESH:D003553	10404	Chemical	Gene	START_ENTITY|dobj|activity activity|amod|END_ENTITY	Serum cystine aminopeptidase and leucine aminopeptidase activity in women with benign and malignant uterine and ovarian_tumors .
924762	0	cystine	6,13	aminopeptidase	41,55	cystine	aminopeptidase	MESH:D003553	10404	Chemical	Gene	START_ENTITY|dobj|activity activity|amod|END_ENTITY	Serum cystine aminopeptidase and leucine aminopeptidase activity in women with benign and malignant uterine and ovarian_tumors .
9154914	0	cystine	67,74	bovine_pancreatic_trypsin_inhibitor	99,134	cystine	bovine pancreatic trypsin inhibitor	MESH:D003553	404172(Tax:9913)	Chemical	Gene	mutants|amod|START_ENTITY mutants|nmod|END_ENTITY	`` Designing out '' disulfide bonds : thermodynamic properties of 30-51 cystine substitution mutants of bovine_pancreatic_trypsin_inhibitor .
9042363	0	cystine	107,114	gamma-cystathionase	120,139	cystine	gamma-cystathionase	MESH:D003553	24962(Tax:10116)	Chemical	Gene	generated|nmod|START_ENTITY generated|nmod|END_ENTITY	Modification of liver cytosol enzyme activities promoted in vitro by reduced sulfur species generated from cystine with gamma-cystathionase .
6111562	0	cystine	26,33	gamma-glutamyl_transpeptidase	85,114	cystine	gamma-glutamyl transpeptidase	MESH:D003553	92086	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Decrease of intracellular cystine content in cystinotic fibroblasts by inhibitors of gamma-glutamyl_transpeptidase .
6240911	0	cystine	32,39	growth_hormone	59,73	cystine	growth hormone	MESH:D003553	102537102	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Amino_acid sequences around the cystine residues in alpaca growth_hormone .
38336	0	cystine	38,45	oxytocinase	62,73	cystine	oxytocinase	MESH:D003553	4012	Chemical	Gene	aminopeptidase|amod|START_ENTITY aminopeptidase|appos|END_ENTITY	Fractionation and characterization of cystine aminopeptidase -LRB- oxytocinase -RRB- and arylamidase of the human placenta .
19852971	0	cystine	11,18	tryptase_beta	77,90	cystine	tryptase beta	MESH:D003553	64499	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Engineered cystine knot miniproteins as potent inhibitors of human mast cell tryptase_beta .
11302733	0	cystine	4,11	xCt	0,3	cystine	xCt	MESH:D003553	23657	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	xCt cystine transporter expression in HEK293 cells : pharmacology and localization .
2607648	1	cystyl	176,182	aminopeptidase	183,197	cystyl	aminopeptidase	CHEBI:23514	10404	Chemical	Gene	-RSB-|amod|START_ENTITY -RSB-|compound|END_ENTITY	Selection of inhibitors for membrane-bound aminopeptidase and cystyl aminopeptidase -RSB- .
12134707	0	cytarabine	69,79	G-CSF	27,32	cytarabine	G-CSF	MESH:D003561	1440	Chemical	Gene	infusion|nmod|START_ENTITY infusion|amod|END_ENTITY	-LSB- Successful treatment with G-CSF and continuous infusion of low-dose cytarabine and etoposide for therapy-related acute_myeloid_leukemia developed during chemotherapy for malignant_lymphoma -RSB- .
18932257	0	cytarabine	81,91	core-binding-factor	13,32	cytarabine	core-binding-factor	MESH:D003561	10153	Chemical	Gene	Treatment|nmod|START_ENTITY Treatment|nmod|END_ENTITY	Treatment of core-binding-factor in acute_myelogenous_leukemia with fludarabine , cytarabine , and granulocyte_colony-stimulating_factor results in improved event-free survival .
10774251	0	cytarabine	170,180	granulocyte-colony_stimulating_factor	91,128	cytarabine	granulocyte-colony stimulating factor	MESH:D003561	1440	Chemical	Gene	infusion|nmod|START_ENTITY infusion|amod|END_ENTITY	-LSB- An elderly patient with myelodysplastic_syndrome successfully treated with combination of granulocyte-colony_stimulating_factor and continuous-drip infusion of low-dose cytarabine and etoposide -RSB- .
10846828	0	cytarabine	9,19	granulocyte_colony-stimulating_factor	56,93	cytarabine	granulocyte colony-stimulating factor	MESH:D003561	1440	Chemical	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	Low-dose cytarabine and aclarubicin in combination with granulocyte_colony-stimulating_factor -LRB- CAG regimen -RRB- for previously treated patients with relapsed or primary resistant acute_myelogenous_leukemia -LRB- AML -RRB- and previously untreated elderly patients with AML , secondary AML , and refractory_anemia_with_excess_blasts_in_transformation .
17420048	0	cytarabine	19,29	granulocyte_colony-stimulating_factor	66,103	cytarabine	granulocyte colony-stimulating factor	MESH:D003561	1440	Chemical	Gene	START_ENTITY|nmod|combination combination|nmod|priming priming|amod|END_ENTITY	Effect of low-dose cytarabine and aclarubicin in combination with granulocyte_colony-stimulating_factor priming -LRB- CAG regimen -RRB- on the outcome of elderly patients with acute_myeloid_leukemia .
19549403	0	cytarabine	10,20	granulocyte_colony-stimulating_factor	57,94	cytarabine	granulocyte colony-stimulating factor	MESH:D003561	1440	Chemical	Gene	START_ENTITY|nmod|combination combination|nmod|priming priming|amod|END_ENTITY	-LSB- Low-dose cytarabine and aclarubicin in combination with granulocyte_colony-stimulating_factor priming in 50 patients with relapsed acute_myeloid_leukemia -RSB- .
21123967	0	cytarabine	126,136	granulocyte_colony-stimulating_factor	39,76	cytarabine	granulocyte colony-stimulating factor	MESH:D003561	1440	Chemical	Gene	induction|nmod|START_ENTITY apoptosis|acl|induction enhances|nmod|apoptosis enhances|nsubj|action action|nmod|END_ENTITY	Cell cycle-dependent priming action of granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- enhances in vitro apoptosis induction by cytarabine and etoposide in leukemia cell lines .
22801963	0	cytarabine	89,99	granulocyte_colony-stimulating_factor	116,153	cytarabine	granulocyte colony-stimulating factor	MESH:D003561	1440	Chemical	Gene	combination|nmod|START_ENTITY fludarabine|nmod|combination fludarabine|nmod|END_ENTITY	Retrospective comparison of clofarabine versus fludarabine in combination with high-dose cytarabine with or without granulocyte_colony-stimulating_factor as salvage therapies for acute_myeloid_leukemia .
23208834	0	cytarabine	80,90	granulocyte_colony-stimulating_factor	134,171	cytarabine	granulocyte colony-stimulating factor	MESH:D003561	1440	Chemical	Gene	consolidation|amod|START_ENTITY receiving|dobj|consolidation receiving|nmod|END_ENTITY	Neutropenia-associated outcomes in adults with acute_myeloid_leukemia receiving cytarabine consolidation chemotherapy with or without granulocyte_colony-stimulating_factor .
23547862	0	cytarabine	101,111	granulocyte_colony-stimulating_factor	20,57	cytarabine	granulocyte colony-stimulating factor	MESH:D003561	1440	Chemical	Gene	therapy|nmod|START_ENTITY use|nmod|therapy use|nmod|END_ENTITY	Prophylactic use of granulocyte_colony-stimulating_factor after consolidation therapy with high-dose cytarabine for acute_myeloid_leukemia .
24623261	0	cytarabine	47,57	granulocyte_colony-stimulating_factor	94,131	cytarabine	granulocyte colony-stimulating factor	MESH:D003561	1440	Chemical	Gene	aclarubicin|nmod|START_ENTITY dose|nmod|aclarubicin Increasing|dobj|dose Increasing|nmod|combination combination|nmod|END_ENTITY	Increasing the dose of aclarubicin in low-dose cytarabine and aclarubicin in combination with granulocyte_colony-stimulating_factor -LRB- CAG regimen -RRB- can safely and effectively treat relapsed or refractory acute_myeloid_leukemia .
25638269	0	cytarabine	21,31	granulocyte_colony-stimulating_factor	68,105	cytarabine	granulocyte colony-stimulating factor	MESH:D003561	1440	Chemical	Gene	Efficacy|nmod|START_ENTITY Efficacy|nmod|END_ENTITY	Efficacy of low-dose cytarabine and aclarubicin in combination with granulocyte_colony-stimulating_factor -LRB- CAG regimen -RRB- compared to Hyper-CVAD regimen as salvage chemotherapy in relapsed/refractory Philadelphia chromosome-negative acute_lymphoblastic_leukemia .
26021434	0	cytarabine	40,50	granulocyte_colony-stimulating_factor	87,124	cytarabine	granulocyte colony-stimulating factor	MESH:D003561	1440	Chemical	Gene	dose|nmod|START_ENTITY dose|nmod|END_ENTITY	Increasing aclarubicin dose in low-dose cytarabine and aclarubicin in combination with granulocyte_colony-stimulating_factor -LRB- CAG regimen -RRB- is efficacious as salvage chemotherapy for relapsed/refractory mixed-phenotype acute leukemia .
26021434	0	cytarabine	40,50	granulocyte_colony-stimulating_factor	87,124	cytarabine	granulocyte colony-stimulating factor	MESH:D003561	1440	Chemical	Gene	dose|nmod|START_ENTITY dose|nmod|END_ENTITY	Increasing aclarubicin dose in low-dose cytarabine and aclarubicin in combination with granulocyte_colony-stimulating_factor -LRB- CAG regimen -RRB- is efficacious as salvage chemotherapy for relapsed/refractory mixed-phenotype acute leukemia .
7512125	0	cytarabine	88,98	granulocyte_colony-stimulating_factor	7,44	cytarabine	granulocyte colony-stimulating factor	MESH:D003561	1440	Chemical	Gene	therapy|amod|START_ENTITY therapy|amod|END_ENTITY	Use of granulocyte_colony-stimulating_factor before , during , and after fludarabine plus cytarabine induction therapy of newly diagnosed acute_myelogenous_leukemia or myelodysplastic_syndromes : comparison with fludarabine plus cytarabine without granulocyte_colony-stimulating_factor .
26563595	0	cytarabine	110,120	interferon_regulatory_factor_8	35,65	cytarabine	interferon regulatory factor 8	MESH:D003561	3394	Chemical	Gene	upregulated|nmod|START_ENTITY upregulated|nsubjpass|END_ENTITY	The hematopoietic_tumor suppressor interferon_regulatory_factor_8 -LRB- IRF8 -RRB- is upregulated by the antimetabolite cytarabine in leukemic cells involving the zinc finger protein ZNF224 , acting as a cofactor of the Wilms ' _ tumor_gene_1 _ -LRB- WT1 -RRB- protein .
16219354	0	cytidine	4,12	AID	23,26	cytidine	AID	MESH:D003562	57379	Chemical	Gene	deaminase|nsubj|START_ENTITY deaminase|ccomp|exhibits exhibits|nsubj|END_ENTITY	The cytidine deaminase AID exhibits similar functional properties in yeast and mammals .
17893327	0	cytidine	67,75	AID	114,117	cytidine	AID	MESH:D003562	57379	Chemical	Gene	structure|nmod|START_ENTITY determine|nsubj|structure determine|dobj|efficiency efficiency|nmod|END_ENTITY	Single-stranded DNA structure and positional context of the target cytidine determine the enzymatic efficiency of AID .
19363484	0	cytidine	35,43	AID	54,57	cytidine	AID	MESH:D003562	57379	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression , class-switch DNA recombination and somatic hypermutation .
19363484	0	cytidine	35,43	AID	73,76	cytidine	AID	MESH:D003562	57379	Chemical	Gene	gene|amod|START_ENTITY promoter|nmod|gene binds|nmod|promoter binds|xcomp|induce induce|dobj|expression expression|compound|END_ENTITY	HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression , class-switch DNA recombination and somatic hypermutation .
20625427	0	cytidine	77,85	AID	97,100	cytidine	AID	MESH:D003562	57379	Chemical	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	CD40 ligand -LRB- CD154 -RRB- incorporated into HIV virions induces activation-induced cytidine deaminase -LRB- AID -RRB- expression in human B lymphocytes .
21255825	0	cytidine	32,40	AID	28,31	cytidine	AID	MESH:D003562	57379	Chemical	Gene	deaminase|compound|START_ENTITY deaminase|compound|END_ENTITY	The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates .
9545269	0	cytidine_6666	53,66	apolipoprotein_B	74,90	cytidine 6666	apolipoprotein B	null	100009101(Tax:9986)	Chemical	Gene	START_ENTITY|nmod|mRNA mRNA|amod|END_ENTITY	Two efficiency elements flanking the editing site of cytidine_6666 in the apolipoprotein_B mRNA support mooring-dependent editing .
8626710	0	cytidines	25,34	apolipoprotein_B	38,54	cytidines	apolipoprotein B	CHEBI:23524	238055(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mRNA mRNA|amod|END_ENTITY	Hyperediting of multiple cytidines of apolipoprotein_B mRNA by APOBEC-1 requires auxiliary protein -LRB- s -RRB- but not a mooring sequence motif .
6980842	0	cytochalasin_B	106,120	C3a	71,74	cytochalasin B	C3a	MESH:D003571	718	Chemical	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	Morphological changes in human polymorphonuclear leukocytes induced by C3a in the presence and absence of cytochalasin_B .
15058574	0	cytochalasin_B	16,30	GLUT1	46,51	cytochalasin B	GLUT1	MESH:D003571	6513	Chemical	Gene	partitioning|nsubj|START_ENTITY partitioning|dep|binding binding|nmod|transporter transporter|compound|END_ENTITY	Ethanol weakens cytochalasin_B binding to the GLUT1 glucose transporter and drug partitioning into lipid bilayers .
2019601	0	cytochalasin_B	60,74	GLUT1	133,138	cytochalasin B	GLUT1	MESH:D003571	100753506	Chemical	Gene	labeling|amod|START_ENTITY activity|amod|labeling activity|nmod|transporter transporter|compound|END_ENTITY	Substitution of leucine_for_tryptophan_412 does not abolish cytochalasin_B labeling but markedly decreases the intrinsic activity of GLUT1 glucose transporter .
27078104	0	cytochalasin_B	80,94	GLUT1	53,58	cytochalasin B	GLUT1	MESH:D003571	6513	Chemical	Gene	conserved|nmod|START_ENTITY conserved|nsubjpass|Mechanism Mechanism|nmod|inhibition inhibition|nmod|END_ENTITY	Mechanism of inhibition of human glucose transporter GLUT1 is conserved between cytochalasin_B and phenylalanine_amides .
8092986	0	cytochalasin_B	76,90	GLUT1	113,118	cytochalasin B	GLUT1	MESH:D003571	100753506	Chemical	Gene	photolabelling|amod|START_ENTITY photolabelling|nmod|transporter transporter|compound|END_ENTITY	Replacement of both tryptophan residues at 388 and 412 completely abolished cytochalasin_B photolabelling of the GLUT1 glucose transporter .
7779771	1	cytochalasin_B	156,170	Glut1	214,219	cytochalasin B	Glut1	MESH:D003571	6513	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of cytochalasin_B and D-glucose with the glucose_transporter Glut1 .
7523197	0	cytokeratin_A	24,37	endo_A	39,45	cytokeratin A	endo A	null	16691(Tax:10090)	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Activation of the mouse cytokeratin_A -LRB- endo_A -RRB- gene in teratocarcinoma F9 cells by the histone deacetylase inhibitor Trichostatin_A .
8896756	0	cytosine	29,37	DNA-methyltransferase	38,59	cytosine	DNA-methyltransferase	MESH:D003596	834975(Tax:3702)	Chemical	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	The methylation pattern of a cytosine DNA-methyltransferase gene in Arabidopsis_thaliana plants .
3264363	0	cytosine	50,58	GM-CSF	22,28	cytosine	GM-CSF	MESH:D003596	1437	Chemical	Gene	metabolism|nmod|START_ENTITY END_ENTITY|nmod|metabolism	Effect of recombinant GM-CSF on the metabolism of cytosine arabinoside in normal and leukemic human bone marrow cells .
24762702	0	cytosine	65,73	MET1	60,64	cytosine	MET1	MESH:D003596	834975(Tax:3702)	Chemical	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	VIM proteins regulate transcription exclusively through the MET1 cytosine methylation pathway .
19918084	0	cytosine	5,13	Puf3p	32,37	cytosine	Puf3p	MESH:D003596	850647(Tax:4932)	Chemical	Gene	pocket|amod|START_ENTITY pocket|nmod|END_ENTITY	A 5 ' cytosine binding pocket in Puf3p specifies regulation of mitochondrial mRNAs .
18374401	0	cytosine-adenine-guanine	18,42	Androgen_receptor	0,17	cytosine-adenine-guanine	Androgen receptor	null	367	Chemical	Gene	polymorphisms|amod|START_ENTITY polymorphisms|amod|END_ENTITY	Androgen_receptor cytosine-adenine-guanine repeat polymorphisms modulate EGFR signaling in epithelial ovarian_carcinomas .
10028846	0	cytosine_arabinoside	112,132	G-CSF	89,94	cytosine arabinoside	G-CSF	MESH:D003561	1440	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	-LSB- Induction of Ph-negative normal clone and long-term survival by combined treatment with G-CSF plus middle dose cytosine_arabinoside for patients with chronic_myeloid_leukemia in blastic transformation -RSB- .
3071344	0	cytosine_arabinoside	79,99	GM-CSF	0,6	cytosine arabinoside	GM-CSF	MESH:D003561	1437	Chemical	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	GM-CSF enhances sensitivity of leukemic clonogenic cells to long-term low dose cytosine_arabinoside with sparing of the normal clonogenic cells .
2654494	0	cytosine_arabinoside	83,103	Granulocyte-macrophage_colony-stimulating_factor	0,48	cytosine arabinoside	Granulocyte-macrophage colony-stimulating factor	MESH:D003561	1437	Chemical	Gene	effects|nmod|START_ENTITY enhances|dobj|effects enhances|nsubj|END_ENTITY	Granulocyte-macrophage_colony-stimulating_factor enhances the cytotoxic effects of cytosine_arabinoside in acute_myeloblastic_leukemia and in the myeloid blast crisis phase of chronic myeloid_leukemia .
3585446	0	cytosine_arabinoside	113,133	L-asparaginase	139,153	cytosine arabinoside	L-asparaginase	MESH:D003561	80150	Chemical	Gene	using|dobj|START_ENTITY using|nmod|END_ENTITY	Evaluation of intensive postremission chemotherapy for adults with acute_nonlymphocytic_leukemia using high-dose cytosine_arabinoside with L-asparaginase and amsacrine with etoposide .
10023854	0	cytosine_arabinoside	71,91	complement_receptor_type_1	27,53	cytosine arabinoside	complement receptor type 1	MESH:D003561	1378	Chemical	Gene	transcription|nmod|START_ENTITY transcription|amod|END_ENTITY	Mechanism of regulation of complement_receptor_type_1 transcription by cytosine_arabinoside in a pre-erythroid model .
8862446	0	cytosine_arabinoside	62,82	cytidine_deaminase	21,39	cytosine arabinoside	cytidine deaminase	MESH:D003561	72269(Tax:10090)	Chemical	Gene	confers|advcl|START_ENTITY confers|nsubj|expression expression|nmod|END_ENTITY	Forced expression of cytidine_deaminase confers resistance to cytosine_arabinoside and gemcitabine .
8289481	0	cytosine_arabinoside	40,60	granulocyte-macrophage_colony-stimulating_factor	76,124	cytosine arabinoside	granulocyte-macrophage colony-stimulating factor	MESH:D003561	1437	Chemical	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	A randomized phase II study of low-dose cytosine_arabinoside -LRB- LD-AraC -RRB- plus granulocyte-macrophage_colony-stimulating_factor -LRB- rhGM-CSF -RRB- in myelodysplastic_syndromes -LRB- MDS -RRB- with a high risk of developing leukemia .
7514282	0	cytosine_arabinoside	117,137	granulocyte_colony-stimulating_factor	24,61	cytosine arabinoside	granulocyte colony-stimulating factor	MESH:D003561	1440	Chemical	Gene	effects|acl|START_ENTITY effects|nmod|END_ENTITY	Cell kinetic effects of granulocyte_colony-stimulating_factor on the sensitivity of nonlymphocytic_leukemia cells to cytosine_arabinoside .
7689779	0	cytosine_arabinoside	99,119	granulocyte_colony-stimulating_factor	18,55	cytosine arabinoside	granulocyte colony-stimulating factor	MESH:D003561	1440	Chemical	Gene	infusion|nmod|START_ENTITY END_ENTITY|nmod|infusion	Recombinant human granulocyte_colony-stimulating_factor in combination with continuous infusion of cytosine_arabinoside for the treatment of refractory acute_myelogenous_leukemia .
1893953	0	cytosine_arabinoside	68,88	interleukin_3	23,36	cytosine arabinoside	interleukin 3	MESH:D003561	3562	Chemical	Gene	metabolism|nmod|START_ENTITY effect|nmod|metabolism effect|nmod|END_ENTITY	Differential effect of interleukin_3 on the metabolism of high-dose cytosine_arabinoside in normal versus leukemic human bone marrow cells .
18186951	0	cytosines	96,105	PPAR_alpha	121,131	cytosines	PPAR alpha	null	25747(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|promoter promoter|compound|END_ENTITY	Feeding pregnant rats a protein-restricted diet persistently alters the methylation of specific cytosines in the hepatic PPAR_alpha promoter of the offspring .
26796213	0	d-Serine	75,83	Asc-1	0,5	d-Serine	Asc-1	CHEBI:16523	104385(Tax:10090)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|compound|END_ENTITY	Asc-1 Transporter Regulation of Synaptic Activity via the Tonic Release of d-Serine in the Forebrain .
16524702	0	d-amphetamine	32,45	neurotensin	84,95	d-amphetamine	neurotensin	MESH:D003913	299757(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|concentrations concentrations|nmod|END_ENTITY	Effects of acute and subchronic d-amphetamine on ventral striatal concentrations of neurotensin and neuropeptide Y in rats treated with antipsychotic drugs .
3748325	0	d-amphetamine	81,94	neurotensin	23,34	d-amphetamine	neurotensin	MESH:D003913	299757(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY locomotor|dep|induced locomotor|nsubj|suppresses suppresses|compound|END_ENTITY	Centrally administered neurotensin suppresses locomotor hyperactivity induced by d-amphetamine but not by scopolamine or caffeine .
9786410	0	d-amphetamine	36,49	neurotensin	79,90	d-amphetamine	neurotensin	MESH:D003913	299757(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|levels levels|nmod|END_ENTITY	Distinct and interactive effects of d-amphetamine and haloperidol on levels of neurotensin and its mRNA in subterritories in the dorsal and ventral striatum of the rat .
20846090	0	d-annulated_benzazepinones	31,57	VEGF-R2	61,68	d-annulated benzazepinones	VEGF-R2	null	3791	Chemical	Gene	START_ENTITY|nmod|kinase kinase|compound|END_ENTITY	Molecular modelling studies on d-annulated_benzazepinones as VEGF-R2 kinase inhibitors using docking and 3D-QSAR .
27058977	0	d-deprenyl	119,129	monoamine_oxidase-B	65,84	d-deprenyl	monoamine oxidase-B	null	4129	Chemical	Gene	target|nmod|START_ENTITY END_ENTITY|nmod|target	High-throughput screening and radioligand binding studies reveal monoamine_oxidase-B as the primary binding target for d-deprenyl .
10023505	0	d-fenfluramine	22,36	Prolactin	0,9	d-fenfluramine	Prolactin	null	5617	Chemical	Gene	START_ENTITY|nsubj|response response|compound|END_ENTITY	Prolactin response to d-fenfluramine in major_depression before and after treatment with serotonin reuptake inhibitors .
11337133	0	d-fenfluramine	22,36	Prolactin	0,9	d-fenfluramine	Prolactin	null	5617	Chemical	Gene	response|acl|START_ENTITY response|compound|END_ENTITY	Prolactin response to d-fenfluramine in postmenopausal women on and off ERT : comparison with young women .
1853948	0	d-fenfluramine	36,50	Prolactin	0,9	d-fenfluramine	Prolactin	null	5617	Chemical	Gene	responses|nmod|START_ENTITY responses|compound|END_ENTITY	Prolactin and cortisol responses to d-fenfluramine in major depression : evidence for diminished responsivity of central serotonergic function .
9330023	0	d-fenfluramine	22,36	Prolactin	0,9	d-fenfluramine	Prolactin	null	5617	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Prolactin response to d-fenfluramine in obsessive-compulsive patients , and outcome of fluvoxamine treatment .
9747408	0	d-fenfluramine	22,36	Prolactin	0,9	d-fenfluramine	Prolactin	null	5617	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Prolactin response to d-fenfluramine is blunted in people with anorexia_nervosa .
1473018	0	d-fenfluramine	10,24	neuropeptide_Y	28,42	d-fenfluramine	neuropeptide Y	null	24604(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|concentration concentration|amod|END_ENTITY	Effect of d-fenfluramine on neuropeptide_Y concentration and release in the paraventricular nucleus of food-deprived rats .
7568634	0	d-fenfluramine	48,62	prolactin	26,35	d-fenfluramine	prolactin	null	5617	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|response response|compound|END_ENTITY	Effect of pindolol on the prolactin response to d-fenfluramine .
9326827	0	d-fenfluramine	91,105	prolactin	69,78	d-fenfluramine	prolactin	null	5617	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Central serotonin activity and aggression : inverse relationship with prolactin response to d-fenfluramine , but not CSF 5-HIAA concentration , in human subjects .
8412572	0	d-fenfluramine	10,24	tryptophan_hydroxylase	70,92	d-fenfluramine	tryptophan hydroxylase	null	24848(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|nmod|END_ENTITY	Effect of d-fenfluramine and 5,7-dihydroxytryptamine on the levels of tryptophan_hydroxylase and its mRNA in rat brain .
21843953	0	d-galactosamine	74,89	IL-22	28,33	d-galactosamine	IL-22	CHEBI:60313	50929(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|effects effects|nmod|END_ENTITY	Hepatoprotective effects of IL-22 on fulminant_hepatic_failure induced by d-galactosamine and lipopolysaccharide in mice .
12470860	0	d-lysergic_acid_diethylamide	17,45	c-Fos	87,92	d-lysergic acid diethylamide	c-Fos	CHEBI:6605	314322(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	The hallucinogen d-lysergic_acid_diethylamide -LRB- d-LSD -RRB- induces the immediate-early gene c-Fos in rat forebrain .
26613404	0	d-mannobiose	55,67	Mana1	77,82	d-mannobiose	Mana1	null	4123	Chemical	Gene	START_ENTITY|nmod|structure structure|compound|END_ENTITY	Preferential binding of E. _ coli with type 1 fimbria to d-mannobiose with the Mana1 > 2Man structure .
16621932	0	d-methylphenidate	91,108	P-glycoprotein	47,61	d-methylphenidate	P-glycoprotein	null	67078(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of the polymorphic efflux transporter P-glycoprotein on the brain accumulation of d-methylphenidate and d-amphetamine .
17655880	5	d-psicose	671,680	MCP-1	684,689	d-psicose	MCP-1	MESH:C003243	6347	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	In this study , we examined the effects of d-psicose on MCP-1 expression in human umbilical vein endothelial cells -LRB- HUVECs -RRB- .
25630251	0	d-serine	36,44	pannexin-1	57,67	d-serine	pannexin-1	CHEBI:16523	24145	Chemical	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	P2X7 R-mediated Ca -LRB- 2 + -RRB- - independent d-serine release via pannexin-1 of the P2X7 R-pannexin-1 complex in astrocytes .
22507034	0	d-serine	32,40	serine_racemase	16,31	d-serine	serine racemase	CHEBI:16523	63826	Chemical	Gene	pathway|amod|START_ENTITY Contribution|dep|pathway Contribution|nmod|END_ENTITY	Contribution of serine_racemase / d-serine pathway to neuronal apoptosis .
23630632	0	d-serine	123,131	serine_racemase	23,38	d-serine	serine racemase	CHEBI:16523	27364(Tax:10090)	Chemical	Gene	rescue|nmod|START_ENTITY causes|parataxis|rescue causes|nsubj|disruption disruption|nmod|END_ENTITY	Neonatal disruption of serine_racemase causes schizophrenia-like behavioral_abnormalities in adulthood : clinical rescue by d-serine .
26851299	0	d-serine	58,66	serine_racemase	32,47	d-serine	serine racemase	CHEBI:16523	63826	Chemical	Gene	production|amod|START_ENTITY regulates|dobj|production regulates|nsubj|compartmentalization compartmentalization|nmod|END_ENTITY	Nuclear compartmentalization of serine_racemase regulates d-serine production .
9407073	0	d-tubocurarine	68,82	nicotinic_acetylcholine_receptor	104,136	d-tubocurarine	nicotinic acetylcholine receptor	MESH:D014403	1137	Chemical	Gene	sites|amod|START_ENTITY sites|nmod|END_ENTITY	Identification of amino_acids contributing to high and low affinity d-tubocurarine sites in the Torpedo nicotinic_acetylcholine_receptor .
24141705	0	dGTP	48,52	SAMHD1	38,44	dGTP	SAMHD1	MESH:C029603	25939	Chemical	Gene	Mechanism|nmod|START_ENTITY Mechanism|nmod|END_ENTITY	Mechanism of allosteric activation of SAMHD1 by dGTP .
24141705	0	dGTP	48,52	SAMHD1	38,44	dGTP	SAMHD1	MESH:C029603	25939	Chemical	Gene	Mechanism|nmod|START_ENTITY Mechanism|nmod|END_ENTITY	Mechanism of allosteric activation of SAMHD1 by dGTP .
8646539	0	dUDP	88,92	dUTPase	42,49	dUDP	dUTPase	CHEBI:28850	34529(Tax:7227)	Chemical	Gene	analogue|appos|START_ENTITY END_ENTITY|nmod|analogue	Crystal structure of the Escherichia_coli dUTPase in complex with a substrate analogue -LRB- dUDP -RRB- .
24995339	0	dUMP	73,77	thymidylate_synthase	27,47	dUMP	thymidylate synthase	MESH:C007267	22171(Tax:10090)	Chemical	Gene	complex|nmod|START_ENTITY END_ENTITY|nmod|complex	Crystal structure of mouse thymidylate_synthase in tertiary complex with dUMP and raltitrexed reveals N-terminus architecture and two different active site conformations .
15971611	0	dUTP	80,84	metallothionein-3	14,31	dUTP	metallothionein-3	CHEBI:17625	4504	Chemical	Gene	toxicity|nmod|START_ENTITY END_ENTITY|nmod|toxicity	-LSB- Affection of metallothionein-3 to dUTPase 's accommodating cellular toxicity of dUTP -RSB- .
24352511	0	dabigatran	93,103	Thrombin	0,8	dabigatran	Thrombin	MESH:C554682	2147	Chemical	Gene	reversibility|nmod|START_ENTITY assess|dobj|reversibility using|advcl|assess generation|acl|using generation|compound|END_ENTITY	Thrombin generation using the calibrated automated thrombinoscope to assess reversibility of dabigatran and rivaroxaban .
24701228	0	dabigatran	23,33	Thrombin	0,8	dabigatran	Thrombin	MESH:C554682	14061(Tax:10090)	Chemical	Gene	attenuates_atherosclerosis|compound|START_ENTITY inhibition|nmod|attenuates_atherosclerosis inhibition|nsubj|END_ENTITY	Thrombin inhibition by dabigatran attenuates_atherosclerosis in ApoE deficient mice .
25103614	0	dabigatran	14,24	Thrombin	52,60	dabigatran	Thrombin	MESH:C554682	2147	Chemical	Gene	therapy|compound|START_ENTITY Monitoring|nmod|therapy Monitoring|acl|using using|dobj|assay assay|compound|END_ENTITY	Monitoring of dabigatran therapy using Hemoclot -LRB- -RRB- Thrombin Inhibitor assay in patients with atrial_fibrillation .
25138021	0	dabigatran	25,35	Thrombin	0,8	dabigatran	Thrombin	MESH:C554682	14061(Tax:10090)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Thrombin inhibition with dabigatran protects against high-fat diet-induced fatty_liver_disease in mice .
18006647	0	dabigatran	70,80	thrombin	50,58	dabigatran	thrombin	MESH:C554682	2147	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	The metabolism and disposition of the oral direct thrombin inhibitor , dabigatran , in humans .
18076218	0	dabigatran	76,86	thrombin	57,65	dabigatran	thrombin	MESH:C554682	2147	Chemical	Gene	START_ENTITY|nsubj|Pharmacokinetics Pharmacokinetics|nmod|inhibitor inhibitor|compound|END_ENTITY	Pharmacokinetics and pharmacodynamics of the direct oral thrombin inhibitor dabigatran in healthy elderly subjects .
21103660	0	dabigatran	47,57	thrombin	28,36	dabigatran	thrombin	MESH:C554682	2147	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|inhibitor inhibitor|compound|END_ENTITY	Effects of the oral , direct thrombin inhibitor dabigatran on five common coagulation assays .
21982327	0	dabigatran	38,48	thrombin	65,73	dabigatran	thrombin	MESH:C554682	2147	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Advances in anticoagulation : focus on dabigatran , an oral direct thrombin inhibitor .
21996066	0	dabigatran	47,57	thrombin	69,77	dabigatran	thrombin	MESH:C554682	2147	Chemical	Gene	quantification|nmod|START_ENTITY quantification|dep|inhibitor inhibitor|compound|END_ENTITY	UPLC MS/MS assay for routine quantification of dabigatran - a direct thrombin inhibitor - in human plasma .
22065286	0	dabigatran	11,21	thrombin	34,42	dabigatran	thrombin	MESH:C554682	2147	Chemical	Gene	START_ENTITY|acl|vitro vitro|nmod|END_ENTITY	Effects of dabigatran in vitro on thrombin biomarkers by Calibrated Automated Thrombography in patients after ischemic_stroke .
22227958	0	dabigatran	89,99	thrombin	26,34	dabigatran	thrombin	MESH:C554682	2147	Chemical	Gene	concentrations|nmod|START_ENTITY determine|dobj|concentrations inhibitor|xcomp|determine inhibitor|csubj|Using Using|dobj|END_ENTITY	Using the HEMOCLOT direct thrombin inhibitor assay to determine plasma concentrations of dabigatran .
22323896	0	dabigatran	35,45	thrombin	74,82	dabigatran	thrombin	MESH:C554682	2147	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	New oral antithrombotics : focus on dabigatran , an oral , reversible direct thrombin inhibitor for the prevention and treatment of venous_and_arterial_thromboembolic_disorders .
22394293	0	dabigatran	140,150	thrombin	38,46	dabigatran	thrombin	MESH:C554682	2147	Chemical	Gene	traumatic_brain_injury|nmod|START_ENTITY catastrophic_hemorrhage|nmod|traumatic_brain_injury complications|dep|catastrophic_hemorrhage complications|nmod|inhibitors inhibitors|compound|END_ENTITY	Neurosurgical complications of direct thrombin inhibitors -- catastrophic_hemorrhage after mild traumatic_brain_injury in a patient receiving dabigatran .
22431533	0	dabigatran	40,50	thrombin	15,23	dabigatran	thrombin	MESH:C554682	2147	Chemical	Gene	concentrations|compound|START_ENTITY measure|dobj|concentrations time|xcomp|measure time|nsubj|END_ENTITY	Plasma-diluted thrombin time to measure dabigatran concentrations during dabigatran_etexilate therapy .
22458575	0	dabigatran	55,65	thrombin	82,90	dabigatran	thrombin	MESH:C554682	2147	Chemical	Gene	using|dobj|START_ENTITY surgery|acl|using Thromboembolic_prophylaxis|nmod|surgery Thromboembolic_prophylaxis|dep|END_ENTITY	Thromboembolic_prophylaxis in orthopedic surgery using dabigatran : an oral direct thrombin inhibitor .
22837011	0	dabigatran	47,57	thrombin	22,30	dabigatran	thrombin	MESH:C554682	14061(Tax:10090)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	The effects of direct thrombin inhibition with dabigatran on plaque formation and endothelial function in apolipoprotein_E-deficient mice .
23631181	0	dabigatran	34,44	thrombin	13,21	dabigatran	thrombin	MESH:C554682	2147	Chemical	Gene	-RSB-|compound|START_ENTITY inhibitor|appos|-RSB- inhibitor|compound|END_ENTITY	-LSB- Direct oral thrombin inhibitor , `` dabigatran '' -RSB- .
23783268	0	dabigatran	14,24	thrombin	118,126	dabigatran	thrombin	MESH:C554682	2147	Chemical	Gene	effect|nmod|START_ENTITY determined|nsubj|effect determined|nmod|assay assay|compound|END_ENTITY	The effect of dabigatran on the activated partial thromboplastin time and thrombin time as determined by the Hemoclot thrombin inhibitor assay in patient plasma samples .
24815541	0	dabigatran	56,66	thrombin	10,18	dabigatran	thrombin	MESH:C554682	14061(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY reduces|dobj|effects reduces|nsubj|END_ENTITY	yT - S195A thrombin reduces the anticoagulant effects of dabigatran in vitro and in vivo .
25193406	0	dabigatran	43,53	thrombin	159,167	dabigatran	thrombin	MESH:C554682	2147	Chemical	Gene	effect|nmod|START_ENTITY unrelated|nsubj|effect unrelated|nmod|increase increase|nmod|generation generation|compound|END_ENTITY	The paradoxical antifibrinolytic effect of dabigatran and argatroban in the presence of soluble thrombomodulin is unrelated to protein_C-dependent increase of thrombin generation .
25874337	0	dabigatran	66,76	thrombin	99,107	dabigatran	thrombin	MESH:C554682	2147	Chemical	Gene	derivatives|compound|START_ENTITY fluorinated|dobj|derivatives fluorinated|nmod|inhibitors inhibitors|compound|END_ENTITY	Design , synthesis and structural exploration of novel fluorinated dabigatran derivatives as direct thrombin inhibitors .
26027859	0	dabigatran	34,44	thrombin	3,11	dabigatran	thrombin	MESH:C554682	2147	Chemical	Gene	anticoagulation|compound|START_ENTITY sensitive|nmod|anticoagulation sensitive|nsubj|time time|compound|END_ENTITY	Is thrombin time too sensitive to dabigatran anticoagulation for clinical decision making in the setting of acute hemorrhage ?
26392631	0	dabigatran	67,77	thrombin	8,16	dabigatran	thrombin	MESH:C554682	2147	Chemical	Gene	concentrations|compound|START_ENTITY low|nmod|concentrations measures|xcomp|low measures|nsubj|time time|compound|END_ENTITY	Diluted thrombin time reliably measures low to intermediate plasma dabigatran concentrations .
26754829	0	dabigatran	67,77	thrombin	46,54	dabigatran	thrombin	MESH:C554682	2147	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|inhibitors inhibitors|compound|END_ENTITY	Evaluation of anticoagulant effects of direct thrombin inhibitors , dabigatran and argatroban , based on the Lineweaver-Burk plot applied to the Clauss assay .
26757012	0	dabigatran	163,173	thrombin	101,109	dabigatran	thrombin	MESH:C554682	2147	Chemical	Gene	comparison|nmod|START_ENTITY evaluation|dep|comparison evaluation|nmod|inhibitor inhibitor|nmod|generation generation|amod|END_ENTITY	An in-vitro evaluation of direct thrombin inhibitor and factor Xa inhibitor on tissue factor-induced thrombin generation and platelet_aggregation : a comparison of dabigatran and rivaroxaban .
26757012	0	dabigatran	163,173	thrombin	33,41	dabigatran	thrombin	MESH:C554682	2147	Chemical	Gene	comparison|nmod|START_ENTITY evaluation|dep|comparison evaluation|nmod|inhibitor inhibitor|compound|END_ENTITY	An in-vitro evaluation of direct thrombin inhibitor and factor Xa inhibitor on tissue factor-induced thrombin generation and platelet_aggregation : a comparison of dabigatran and rivaroxaban .
25193406	0	dabigatran	43,53	thrombomodulin	96,110	dabigatran	thrombomodulin	MESH:C554682	7056	Chemical	Gene	START_ENTITY|nmod|presence presence|nmod|END_ENTITY	The paradoxical antifibrinolytic effect of dabigatran and argatroban in the presence of soluble thrombomodulin is unrelated to protein_C-dependent increase of thrombin generation .
15333033	0	dabigatran_etexilate	70,90	thrombin	50,58	dabigatran etexilate	thrombin	MESH:C453962	2147	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Dose escalating safety study of a new oral direct thrombin inhibitor , dabigatran_etexilate , in patients undergoing total hip replacement : BISTRO I. BACKGROUND : Dabigatran_etexilate -LRB- BIBR_1048 -RRB- is an oral direct thrombin inhibitor undergoing evaluation for the prevention of venous_thromboembolism -LRB- VTE -RRB- following total hip replacement .
15634273	0	dabigatran_etexilate	38,58	thrombin	18,26	dabigatran etexilate	thrombin	MESH:C453962	2147	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	A new oral direct thrombin inhibitor , dabigatran_etexilate , compared with enoxaparin for prevention of thromboembolic_events following total hip or knee replacement : the BISTRO II randomized trial .
15831779	0	dabigatran_etexilate	62,82	thrombin	43,51	dabigatran etexilate	thrombin	MESH:C453962	2147	Chemical	Gene	START_ENTITY|nsubj|profile profile|nmod|inhibitor inhibitor|compound|END_ENTITY	Pharmacokinetic profile of the oral direct thrombin inhibitor dabigatran_etexilate in healthy volunteers and patients undergoing total hip replacement .
17362226	0	dabigatran_etexilate	108,128	thrombin	55,63	dabigatran etexilate	thrombin	MESH:C453962	100009146(Tax:9986)	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|dabigatran dabigatran|compound|END_ENTITY	Antithrombotic and anticoagulant effects of the direct thrombin inhibitor dabigatran , and its oral prodrug , dabigatran_etexilate , in a rabbit model of venous_thrombosis .
17506785	0	dabigatran_etexilate	59,79	thrombin	99,107	dabigatran etexilate	thrombin	MESH:C453962	2147	Chemical	Gene	pharmacodynamics|nmod|START_ENTITY pharmacokinetics|appos|pharmacodynamics pharmacokinetics|appos|inhibitor inhibitor|compound|END_ENTITY	The pharmacokinetics , pharmacodynamics and tolerability of dabigatran_etexilate , a new oral direct thrombin inhibitor , in healthy male subjects .
17598008	0	dabigatran_etexilate	127,147	thrombin	66,74	dabigatran etexilate	thrombin	MESH:C453962	2147	Chemical	Gene	START_ENTITY|nsubj|profile profile|nmod|dabigatran dabigatran|compound|END_ENTITY	In-vitro profile and ex-vivo anticoagulant activity of the direct thrombin inhibitor dabigatran and its orally active prodrug , dabigatran_etexilate .
17721615	0	dabigatran_etexilate	83,103	thrombin	22,30	dabigatran etexilate	thrombin	MESH:C453962	29251(Tax:10116)	Chemical	Gene	Effects|appos|START_ENTITY Effects|nmod|dabigatran dabigatran|compound|END_ENTITY	Effects of the direct thrombin inhibitor dabigatran and its orally active prodrug , dabigatran_etexilate , on thrombus formation and bleeding time in rats .
18399711	0	dabigatran_etexilate	85,105	thrombin	66,74	dabigatran etexilate	thrombin	MESH:C453962	2147	Chemical	Gene	START_ENTITY|nsubj|pharmacokinetics pharmacokinetics|nmod|inhibitor inhibitor|compound|END_ENTITY	Clinical pharmacokinetics and pharmacodynamics of the oral direct thrombin inhibitor dabigatran_etexilate .
18534438	0	dabigatran_etexilate	24,44	thrombin	5,13	dabigatran etexilate	thrombin	MESH:C453962	2147	Chemical	Gene	START_ENTITY|nsubj|inhibitor inhibitor|compound|END_ENTITY	Oral thrombin inhibitor dabigatran_etexilate vs North American enoxaparin regimen for prevention of venous_thromboembolism after knee arthroplasty surgery .
18827075	0	dabigatran_etexilate	41,61	thrombin	78,86	dabigatran etexilate	thrombin	MESH:C453962	2147	Chemical	Gene	Pharmacokinetics|nmod|START_ENTITY Pharmacokinetics|appos|inhibitor inhibitor|compound|END_ENTITY	Pharmacokinetics and pharmacodynamics of dabigatran_etexilate , an oral direct thrombin inhibitor , are not affected by moderate hepatic_impairment .
21312187	0	dabigatran_etexilate	80,100	thrombin	61,69	dabigatran etexilate	thrombin	MESH:C453962	14061(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|inhibitor inhibitor|compound|END_ENTITY	Antiinflammatory and antifibrotic effects of the oral direct thrombin inhibitor dabigatran_etexilate in a murine model of interstitial_lung_disease .
21868715	0	dabigatran_etexilate	41,61	thrombin	78,86	dabigatran etexilate	thrombin	MESH:C453962	2147	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Pharmacokinetics and pharmacodynamics of dabigatran_etexilate , an oral direct thrombin inhibitor , with coadministration of digoxin .
21972820	0	dabigatran_etexilate	67,87	thrombin	48,56	dabigatran etexilate	thrombin	MESH:C453962	2147	Chemical	Gene	START_ENTITY|nsubj|analysis analysis|nmod|inhibitor inhibitor|compound|END_ENTITY	Population pharmacokinetic analysis of the oral thrombin inhibitor dabigatran_etexilate in patients with non-valvular atrial_fibrillation from the RE-LY trial .
22431533	0	dabigatran_etexilate	73,93	thrombin	15,23	dabigatran etexilate	thrombin	MESH:C453962	2147	Chemical	Gene	therapy|amod|START_ENTITY measure|nmod|therapy time|xcomp|measure time|nsubj|END_ENTITY	Plasma-diluted thrombin time to measure dabigatran concentrations during dabigatran_etexilate therapy .
22940777	0	dabigatran_etexilate	174,194	thrombin	35,43	dabigatran etexilate	thrombin	MESH:C453962	14061(Tax:10090)	Chemical	Gene	effects|dep|START_ENTITY effects|nmod|inhibitor inhibitor|compound|END_ENTITY	The beneficial effects of a direct thrombin inhibitor , dabigatran_etexilate , on the development and stability of atherosclerotic_lesions in apolipoprotein_E-deficient mice : dabigatran_etexilate and atherosclerosis .
22940777	0	dabigatran_etexilate	55,75	thrombin	35,43	dabigatran etexilate	thrombin	MESH:C453962	14061(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	The beneficial effects of a direct thrombin inhibitor , dabigatran_etexilate , on the development and stability of atherosclerotic_lesions in apolipoprotein_E-deficient mice : dabigatran_etexilate and atherosclerosis .
23783171	0	dabigatran_etexilate	131,151	thrombin	32,40	dabigatran etexilate	thrombin	MESH:C453962	2147	Chemical	Gene	treated|nmod|START_ENTITY Comparison|acl|treated Comparison|nmod|time time|amod|END_ENTITY	Comparison of calibrated dilute thrombin time and aPTT tests with LC-MS/MS for the therapeutic monitoring of patients treated with dabigatran_etexilate .
24592851	0	dabigatran_etexilate	34,54	thrombin	88,96	dabigatran etexilate	thrombin	MESH:C453962	2147	Chemical	Gene	dose-adjustment|nmod|START_ENTITY proposal|nmod|dose-adjustment guided|nsubj|proposal guided|nmod|time time|compound|END_ENTITY	A proposal for dose-adjustment of dabigatran_etexilate in atrial_fibrillation guided by thrombin time .
26537784	0	dabigatran_etexilate	57,77	thrombin	116,124	dabigatran etexilate	thrombin	MESH:C453962	29251(Tax:10116)	Chemical	Gene	analogs|compound|START_ENTITY evaluation|nmod|analogs Design|appos|evaluation Design|appos|series series|nmod|inhibitors inhibitors|compound|END_ENTITY	Design , synthesis and antithrombotic evaluation of novel dabigatran_etexilate analogs , a new series of non-peptides thrombin inhibitors .
22389471	0	dabrafenib	114,124	BRAF	16,20	dabrafenib	BRAF	MESH:C561627	673	Chemical	Gene	overcome|nmod|START_ENTITY inhibitors|xcomp|overcome inhibitors|nsubj|Combinations Combinations|nmod|END_ENTITY	Combinations of BRAF , MEK , and PI3K/mTOR inhibitors overcome acquired resistance to the BRAF inhibitor GSK2118436 dabrafenib , mediated by NRAS or MEK mutations .
22804352	0	dabrafenib	28,38	BRAF	85,89	dabrafenib	BRAF	MESH:C561627	673	Chemical	Gene	manifestations|nmod|START_ENTITY manifestations|dep|inhibitor inhibitor|nmod|END_ENTITY	Cutaneous manifestations of dabrafenib -LRB- GSK2118436 -RRB- : a selective inhibitor of mutant BRAF in patients with metastatic_melanoma .
22981500	0	dabrafenib	116,126	BRAF	135,139	dabrafenib	BRAF	MESH:C561627	673	Chemical	Gene	metastatic_melanoma|compound|START_ENTITY metastatic_melanoma|compound|END_ENTITY	-LRB- 18 -RRB- F-labelled fluorodeoxyglucose-positron emission tomography -LRB- FDG-PET -RRB- heterogeneity of response is prognostic in dabrafenib treated BRAF mutant metastatic_melanoma .
23317446	0	dabrafenib	10,20	BRAF	59,63	dabrafenib	BRAF	MESH:C561627	673	Chemical	Gene	START_ENTITY|nmod|lines lines|acl|harbouring harbouring|dobj|END_ENTITY	Effect of dabrafenib on melanoma cell lines harbouring the BRAF -LRB- V600D/R -RRB- mutations .
23470635	0	dabrafenib	91,101	BRAF	0,4	dabrafenib	BRAF	MESH:C561627	673	Chemical	Gene	regression|nmod|START_ENTITY report|nmod|regression gastrointestinal_stromal_tumor|dep|report gastrointestinal_stromal_tumor|amod|END_ENTITY	BRAF mutant gastrointestinal_stromal_tumor : first report of regression with BRAF inhibitor dabrafenib -LRB- GSK2118436 -RRB- and whole exomic sequencing for analysis of acquired resistance .
23608920	0	dabrafenib	93,103	BRAF	107,111	dabrafenib	BRAF	MESH:C561627	673	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effects of particle size , food , and capsule shell composition on the oral bioavailability of dabrafenib , a BRAF inhibitor , in patients with BRAF mutation-positive tumors .
23608920	0	dabrafenib	93,103	BRAF	140,144	dabrafenib	BRAF	MESH:C561627	673	Chemical	Gene	bioavailability|nmod|START_ENTITY Effects|nmod|bioavailability Effects|nmod|patients patients|nmod|tumors tumors|amod|END_ENTITY	Effects of particle size , food , and capsule shell composition on the oral bioavailability of dabrafenib , a BRAF inhibitor , in patients with BRAF mutation-positive tumors .
23621583	0	dabrafenib	24,34	BRAF	38,42	dabrafenib	BRAF	MESH:C561627	673	Chemical	Gene	development|nmod|START_ENTITY development|nmod|melanoma melanoma|amod|END_ENTITY	Clinical development of dabrafenib in BRAF mutant melanoma and other malignancies .
23846776	0	dabrafenib	53,63	BRAF	100,104	dabrafenib	BRAF	MESH:C561627	673	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY Concomitant|dobj|pharmacokinetics Concomitant|nmod|patients patients|nmod|tumors tumors|compound|END_ENTITY	Concomitant oral and intravenous pharmacokinetics of dabrafenib , a BRAF inhibitor , in patients with BRAF V600 mutation-positive solid tumors .
23846776	0	dabrafenib	53,63	BRAF	67,71	dabrafenib	BRAF	MESH:C561627	673	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Concomitant oral and intravenous pharmacokinetics of dabrafenib , a BRAF inhibitor , in patients with BRAF V600 mutation-positive solid tumors .
24408395	0	dabrafenib	31,41	BRAF	45,49	dabrafenib	BRAF	MESH:C561627	673	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Population pharmacokinetics of dabrafenib , a BRAF inhibitor : effect of dose , time , covariates , and relationship with its metabolites .
24769640	0	dabrafenib	134,144	BRAF	39,43	dabrafenib	BRAF	MESH:C561627	673	Chemical	Gene	comparing|dobj|START_ENTITY study|acl|comparing analyses|nmod|study perception|dep|analyses perception|nmod|benefit benefit|nmod|inhibitor inhibitor|amod|END_ENTITY	Patient perception of the benefit of a BRAF inhibitor in metastatic melanoma : quality-of-life analyses of the BREAK-3 study comparing dabrafenib with dacarbazine .
25435907	0	dabrafenib	21,31	BRAF	64,68	dabrafenib	BRAF	MESH:C561627	673	Chemical	Gene	combination|amod|START_ENTITY combination|nmod|cholangiocarcinoma cholangiocarcinoma|compound|END_ENTITY	Dramatic response to dabrafenib and trametinib combination in a BRAF V600E-mutated cholangiocarcinoma : implementation of a molecular tumour board and next-generation sequencing for personalized medicine .
25466451	0	dabrafenib	12,22	BRAF	83,87	dabrafenib	BRAF	MESH:C561627	673	Chemical	Gene	START_ENTITY|nmod|adenocarcinoma adenocarcinoma|amod|vemurafenib vemurafenib|nmod|patient patient|nmod|V600E-mutant V600E-mutant|compound|END_ENTITY	Response to dabrafenib after progression on vemurafenib in a patient with advanced BRAF V600E-mutant bronchial adenocarcinoma .
25499274	0	dabrafenib	17,27	BRAF	68,72	dabrafenib	BRAF	MESH:C561627	673	Chemical	Gene	guidance|nmod|START_ENTITY guidance|advcl|treating treating|dobj|melanoma melanoma|compound|END_ENTITY	NICE guidance on dabrafenib for treating unresectable or metastatic BRAF V600 mutation-positive melanoma .
25549723	0	dabrafenib	98,108	BRAF	39,43	dabrafenib	BRAF	MESH:C561627	673	Chemical	Gene	V600E-mutant|nmod|START_ENTITY V600E-mutant|nsubj|Redifferentiation Redifferentiation|nmod|END_ENTITY	Redifferentiation of iodine-refractory BRAF V600E-mutant metastatic papillary_thyroid_cancer with dabrafenib .
25779165	0	dabrafenib	53,63	BRAF	38,42	dabrafenib	BRAF	MESH:C561627	673	Chemical	Gene	Combining|dep|START_ENTITY Combining|dobj|inhibitor inhibitor|amod|END_ENTITY	Combining targeted and immunotherapy : BRAF inhibitor dabrafenib -LRB- D -RRB- the MEK inhibitor trametinib -LRB- T -RRB- in combination with ipilimumab -LRB- Ipi -RRB- for V600E/K mutation-positive unresectable or metastatic_melanoma -LRB- MM -RRB- .
25794603	0	dabrafenib	125,135	BRAF	165,169	dabrafenib	BRAF	MESH:C561627	673	Chemical	Gene	monotherapy|amod|START_ENTITY monotherapy|nmod|patients patients|nmod|melanoma melanoma|compound|END_ENTITY	Health-related quality of life impact in a randomised phase III study of the combination of dabrafenib and trametinib versus dabrafenib monotherapy in patients with BRAF V600 metastatic melanoma .
25794603	0	dabrafenib	92,102	BRAF	165,169	dabrafenib	BRAF	MESH:C561627	673	Chemical	Gene	combination|nmod|START_ENTITY study|nmod|combination quality|nmod|study quality|nmod|monotherapy monotherapy|nmod|patients patients|nmod|melanoma melanoma|compound|END_ENTITY	Health-related quality of life impact in a randomised phase III study of the combination of dabrafenib and trametinib versus dabrafenib monotherapy in patients with BRAF V600 metastatic melanoma .
25795880	3	dabrafenib	938,948	BRAF	980,984	dabrafenib	BRAF	MESH:C561627	673	Chemical	Gene	combination|nmod|START_ENTITY synergistic|nmod|combination synergistic|nmod|vemurafenib vemurafenib|appos|inhibitor inhibitor|amod|END_ENTITY	We show that the MEK inhibitor trametinib is more synergistic in combination with the BRAF inhibitor dabrafenib than with vemurafenib , another BRAF inhibitor .
26332527	0	dabrafenib	49,59	BRAF	97,101	dabrafenib	BRAF	MESH:C561627	673	Chemical	Gene	START_ENTITY|nmod|therapy therapy|nmod|V600-mutated V600-mutated|compound|END_ENTITY	A cost-effectiveness analysis of trametinib plus dabrafenib as first-line therapy for metastatic BRAF V600-mutated melanoma in the Swiss setting .
26340744	0	dabrafenib	91,101	BRAF	121,125	dabrafenib	BRAF	MESH:C561627	673	Chemical	Gene	START_ENTITY|nmod|melanoma melanoma|compound|END_ENTITY	Adjusting for confounding effects of treatment switching in a randomized phase II study of dabrafenib plus trametinib in BRAF V600 + metastatic melanoma .
26433819	0	dabrafenib	14,24	BRAF	177,181	dabrafenib	BRAF	MESH:C561627	673	Chemical	Gene	therapy|amod|START_ENTITY therapy|nmod|melanoma melanoma|compound|END_ENTITY	Comparison of dabrafenib and trametinib combination therapy with vemurafenib monotherapy on health-related quality of life in patients with unresectable or metastatic cutaneous BRAF Val600-mutation-positive melanoma -LRB- COMBI-v -RRB- : results of a phase 3 , open-label , randomised trial .
26512791	0	dabrafenib	108,118	BRAF	57,61	dabrafenib	BRAF	MESH:C561627	673	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|Granulomatous_nephritis Granulomatous_nephritis|nmod|patient patient|nmod|melanoma melanoma|compound|END_ENTITY	Granulomatous_nephritis and dermatitis in a patient with BRAF V600E mutant metastatic melanoma treated with dabrafenib and trametinib .
27080364	0	dabrafenib	33,43	BRAF	47,51	dabrafenib	BRAF	MESH:C561627	673	Chemical	Gene	Pustular_psoriasis_eruption|nmod|START_ENTITY inhibitor|advcl|Pustular_psoriasis_eruption inhibitor|nsubj|END_ENTITY	Pustular_psoriasis_eruption with dabrafenib , a BRAF inhibitor .
24901049	0	dabrafenib	27,37	RIP3	59,63	dabrafenib	RIP3	MESH:C561627	11035	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	The B-Raf -LRB- V600E -RRB- inhibitor dabrafenib selectively inhibits RIP3 and alleviates acetaminophen-induced liver_injury .
25933939	0	dacarbazine	58,69	IFN-alpha	26,35	dacarbazine	IFN-alpha	MESH:D003606	3439	Chemical	Gene	cells|nmod|START_ENTITY cells|amod|END_ENTITY	Intratumoral injection of IFN-alpha dendritic cells after dacarbazine activates anti-tumor immunity : results from a phase I trial in advanced melanoma .
8513453	0	dacarbazine	52,63	interferon_alpha-2a	12,31	dacarbazine	interferon alpha-2a	MESH:D003606	3440	Chemical	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	Recombinant interferon_alpha-2a in combination with dacarbazine in the treatment of metastatic malignant_melanoma : analysis of long-term responding patients .
8205559	0	dacarbazine	47,58	interleukin-2	108,121	dacarbazine	interleukin-2	MESH:D003606	3558	Chemical	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	A phase II study of combined administration of dacarbazine and carboplatin with home therapy of recombinant interleukin-2 and interferon-alpha_2a in patients with advanced malignant_melanoma .
15894034	0	daidzein	111,119	3alpha-HSD	51,61	daidzein	3alpha-HSD	MESH:C004742	8644	Chemical	Gene	activity|amod|START_ENTITY activity|dep|END_ENTITY	Inhibition of 3alpha-hydroxysteroid_dehydrogenase -LRB- 3alpha-HSD -RRB- activity of human lung microsomes by genistein , daidzein , coumestrol and C -LRB- 18 -RRB- - , _ C -LRB- 19 -RRB- - _ and_C -LRB- 21 -RRB- - hydroxysteroids and ketosteroids .
15894034	0	daidzein	111,119	3alpha-hydroxysteroid_dehydrogenase	14,49	daidzein	3alpha-hydroxysteroid dehydrogenase	MESH:C004742	8644	Chemical	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Inhibition of 3alpha-hydroxysteroid_dehydrogenase -LRB- 3alpha-HSD -RRB- activity of human lung microsomes by genistein , daidzein , coumestrol and C -LRB- 18 -RRB- - , _ C -LRB- 19 -RRB- - _ and_C -LRB- 21 -RRB- - hydroxysteroids and ketosteroids .
22088592	0	daidzein	12,20	steroid_receptor_coactivator-1	24,54	daidzein	steroid receptor coactivator-1	MESH:C004742	17977(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effects of daidzein on steroid_receptor_coactivator-1 expression in MC3T3-E1 cells and the mechanism -RSB- .
20043933	0	daidzein	16,24	vitellogenin_II	44,59	daidzein	vitellogenin II	MESH:C004742	424533(Tax:9031)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|amod|END_ENTITY	Dual effects of daidzein on chicken hepatic vitellogenin_II expression and estrogen receptor-mediated transactivation in vitro .
22969825	0	daiokanzoto	22,33	p-glycoprotein	61,75	daiokanzoto	p-glycoprotein	null	5243	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Inhibitory effects of daiokanzoto -LRB- da-huang-gan-cao-tang -RRB- on p-glycoprotein .
19825813	5	dalcetrapib	1568,1579	CETP	1543,1547	dalcetrapib	CETP	MESH:C411602	1071	Chemical	Gene	inhibitors|nmod|START_ENTITY inhibitors|compound|END_ENTITY	New CETP inhibitors , such as dalcetrapib and anacetrapib , are targeted to normalize HDL/apoA-I levels and anti-atherogenic activities of HDL particles .
21982411	0	dalcetrapib	10,21	CETP	25,29	dalcetrapib	CETP	MESH:C411602	1071	Chemical	Gene	START_ENTITY|appos|modulator modulator|compound|END_ENTITY	Effect of dalcetrapib , a CETP modulator , on non-cholesterol_sterol markers of cholesterol homeostasis in healthy subjects .
7647979	0	daltroban	77,86	thromboxane_A2_receptor	41,64	daltroban	thromboxane A2 receptor	MESH:C051762	6915	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Intrinsic activity of the non-prostanoid thromboxane_A2_receptor antagonist , daltroban -LRB- BM 13,505 -RRB- , in human platelets in vitro and in the rat vasculature in vivo .
23659170	0	dammarane	52,61	caspase-8	13,22	dammarane	caspase-8	MESH:C102963	841	Chemical	Gene	receptors|nmod|START_ENTITY receptors|amod|END_ENTITY	Induction of caspase-8 and death receptors by a new dammarane skeleton from the dried fruits of Forsythia koreana .
2772500	1	danazol	34,41	C1INH	63,68	danazol	C1INH	MESH:D003613	710	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|-RSB- -RSB-|compound|END_ENTITY	Effect of danazol on C4 and functional C1INH -RSB- .
2145451	0	danazol	12,19	C4b-binding_protein	50,69	danazol	C4b-binding protein	MESH:D003613	722	Chemical	Gene	-RSB-|amod|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Effects of danazol on plasma levels of protein S C4b-binding_protein -RSB- .
1390280	0	danazol	35,42	Progesterone_receptor	0,21	danazol	Progesterone receptor	MESH:D003613	25154(Tax:10116)	Chemical	Gene	induction|nmod|START_ENTITY induction|nsubj|END_ENTITY	Progesterone_receptor induction by danazol in cultured cancer cells and the rat uterus .
2146853	0	danazol	13,20	insulin	38,45	danazol	insulin	MESH:D003613	3630	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of danazol and goserelin on insulin and glucagon in non-obese women with endometriosis .
9478307	0	danazol	55,62	insulin	25,32	danazol	insulin	MESH:D003613	3630	Chemical	Gene	sensitivity|nmod|START_ENTITY sensitivity|nmod|END_ENTITY	Decreased sensitivity to insulin during treatment with danazol in women with endometriosis .
9408086	0	danazol	11,18	sex_hormone-binding_globulin	39,67	danazol	sex hormone-binding globulin	MESH:D003613	6462	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|amod|END_ENTITY	Effects of danazol and progesterone on sex_hormone-binding_globulin mRNA expression in human endometrial_cancer cell line Ishikawa .
3304725	0	danazol	26,33	sex_hormone_binding_globulin	37,65	danazol	sex hormone binding globulin	MESH:D003613	6462	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Dosage-related effects of danazol on sex_hormone_binding_globulin and free and total androgen levels .
3641693	0	danazol	31,38	sex_hormone_binding_globulin	81,109	danazol	sex hormone binding globulin	MESH:D003613	6462	Chemical	Gene	effects|nmod|START_ENTITY comparison|nmod|effects testosterone|nsubj|comparison testosterone|xcomp|binding binding|xcomp|END_ENTITY	A comparison of the effects of danazol and gestrinone on testosterone binding to sex_hormone_binding_globulin in vitro and in vivo .
6135446	0	dansyl_propranolol	11,29	ATPase	51,57	dansyl propranolol	ATPase	MESH:C038695	1769	Chemical	Gene	Binding|nmod|START_ENTITY Binding|dep|END_ENTITY	Binding of dansyl_propranolol to the -LRB- Ca2 + + Mg2 + -RRB- - ATPase .
15751944	0	dansylamide	80,91	carbonic_anhydrase_I	103,123	dansylamide	carbonic anhydrase I	MESH:C001026	759	Chemical	Gene	basis|nmod|START_ENTITY basis|nmod|END_ENTITY	Molecular basis for the origin of differential spectral and binding profiles of dansylamide with human carbonic_anhydrase_I and II .
7392786	0	dantrolene	72,82	AP-A	63,67	dantrolene	AP-A	MESH:D003620	2028	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of the positive inotropic effect of anthopleurin-A -LRB- AP-A -RRB- by dantrolene .
21039984	0	dantrolene	11,21	NeuN	73,77	dantrolene	NeuN	MESH:D003620	287847(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of dantrolene on apoptosis and immunohistochemical expression of NeuN in the spinal cord after traumatic_injury in rats .
3560428	0	dantrolene	26,36	albumin	54,61	dantrolene	albumin	MESH:D003620	213	Chemical	Gene	-RSB-|amod|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- The interactions between dantrolene and bovine serum albumin -RSB- .
7392786	0	dantrolene	72,82	anthopleurin-A	47,61	dantrolene	anthopleurin-A	MESH:D003620	2028	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|effect effect|nmod|END_ENTITY	Inhibition of the positive inotropic effect of anthopleurin-A -LRB- AP-A -RRB- by dantrolene .
24050445	0	dapagliflozin	89,102	SGLT-2	1,7	dapagliflozin	SGLT-2	MESH:C529054	6524	Chemical	Gene	-RSB-|compound|START_ENTITY effect|nmod|-RSB- review|nmod|effect inhibitors|dep|review inhibitors|compound|END_ENTITY	-LSB- SGLT-2 inhibitors : diabetes treatment by glycosuria ; literature review on the effect of dapagliflozin -RSB- .
24443793	0	dapagliflozin	37,50	SGLT-2	20,26	dapagliflozin	SGLT-2	MESH:C529054	6524	Chemical	Gene	treatment|compound|START_ENTITY inhibitor|dobj|treatment inhibitor|nsubj|effects effects|nmod|END_ENTITY	Modeling effects of SGLT-2 inhibitor dapagliflozin treatment versus standard diabetes therapy on cardiovascular and microvascular outcomes .
18260618	0	dapagliflozin	13,26	SGLT2	96,101	dapagliflozin	SGLT2	MESH:C529054	64522(Tax:10116)	Chemical	Gene	Discovery|nmod|START_ENTITY Discovery|dep|inhibitor inhibitor|appos|END_ENTITY	Discovery of dapagliflozin : a potent , selective renal sodium-dependent_glucose_cotransporter_2 -LRB- SGLT2 -RRB- inhibitor for the treatment of type 2 diabetes .
21435141	0	dapagliflozin	53,66	SGLT2	80,85	dapagliflozin	SGLT2	MESH:C529054	6524	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Effect of a high-fat meal on the pharmacokinetics of dapagliflozin , a selective SGLT2 inhibitor , in healthy subjects .
22446170	0	dapagliflozin	11,24	SGLT2	29,34	dapagliflozin	SGLT2	MESH:C529054	6524	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Effects of dapagliflozin , an SGLT2 inhibitor , on HbA -LRB- 1c -RRB- , body weight , and hypoglycemia risk in patients with type 2 diabetes inadequately controlled on pioglitazone monotherapy .
22923998	0	dapagliflozin	48,61	SGLT2	101,106	dapagliflozin	SGLT2	MESH:C529054	6524	Chemical	Gene	Targeting|nmod|START_ENTITY evidence|dep|Targeting evidence|nmod|END_ENTITY	Targeting the kidney and glucose_excretion with dapagliflozin : preclinical and clinical evidence for SGLT2 inhibition as a new option for treatment of type_2_diabetes_mellitus .
23910664	0	dapagliflozin	79,92	SGLT2	119,124	dapagliflozin	SGLT2	MESH:C529054	6524	Chemical	Gene	single|nmod|START_ENTITY properties|nmod|single properties|appos|inhibitor inhibitor|nmod|END_ENTITY	Pharmacokinetic and pharmacodynamic properties of single - and multiple-dose of dapagliflozin , a selective inhibitor of SGLT2 , in healthy Chinese subjects .
24130972	0	dapagliflozin	22,35	SGLT2	0,5	dapagliflozin	SGLT2	MESH:C529054	6524	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nummod|END_ENTITY	SGLT2 inhibition with dapagliflozin -- a novel approach for the management of type 2 diabetes .
25805666	4	dapagliflozin	612,625	SGLT2	554,559	dapagliflozin	SGLT2	MESH:C529054	6524	Chemical	Gene	empagliflozin|compound|START_ENTITY countries|appos|empagliflozin available|nmod|countries available|nsubj|inhibitors inhibitors|compound|END_ENTITY	Several SGLT2 inhibitors are already available in many countries -LRB- dapagliflozin , canagliflozin , empagliflozin -RRB- and in Japan -LRB- ipragliflozin , tofogliflozin -RRB- .
26474563	0	dapagliflozin	23,36	SGLT2	72,77	dapagliflozin	SGLT2	MESH:C529054	6524	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|appos|END_ENTITY	Efficacy and safety of dapagliflozin , a sodium_glucose cotransporter 2 -LRB- SGLT2 -RRB- inhibitor , in diabetes_mellitus .
26878357	0	dapagliflozin	90,103	SGLT2	22,27	dapagliflozin	SGLT2	MESH:C529054	6524	Chemical	Gene	trials|amod|START_ENTITY volume_reduction|nmod|trials related|xcomp|volume_reduction events|acl|related analysis|nmod|events diuresis|dep|analysis diuresis|nmod|inhibition inhibition|compound|END_ENTITY	Osmotic diuresis with SGLT2 inhibition : analysis of events related to volume_reduction in dapagliflozin clinical trials .
21110743	0	dapagliflozin	52,65	sodium-glucose_co-transporter_2	69,100	dapagliflozin	sodium-glucose co-transporter 2	MESH:C529054	64522(Tax:10116)	Chemical	Gene	determination|nmod|START_ENTITY methods|nmod|determination rat|nsubj|methods rat|nsubj|inhibitor inhibitor|amod|END_ENTITY	Validated LC-MS/MS methods for the determination of dapagliflozin , a sodium-glucose_co-transporter_2 inhibitor in normal and ZDF rat plasma .
24474422	0	dapagliflozin	63,76	sodium-glucose_co-transporter_2	94,125	dapagliflozin	sodium-glucose co-transporter 2	MESH:C529054	246787(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Carcinogenicity risk assessment supports the chronic safety of dapagliflozin , an inhibitor of sodium-glucose_co-transporter_2 , in the treatment of type_2_diabetes_mellitus .
21226818	0	dapagliflozin	41,54	sodium-glucose_co-transporter_type_2	87,123	dapagliflozin	sodium-glucose co-transporter type 2	MESH:C529054	6524	Chemical	Gene	Pharmacokinetics|nmod|START_ENTITY Pharmacokinetics|appos|inhibitor inhibitor|nmod|END_ENTITY	Pharmacokinetics and pharmacodynamics of dapagliflozin , a novel selective inhibitor of sodium-glucose_co-transporter_type_2 , in Japanese subjects without and with type_2_diabetes_mellitus .
24097127	0	dapagliflozin	65,78	sodium-glucose_cotransporter_2	97,127	dapagliflozin	sodium-glucose cotransporter 2	MESH:C529054	6524	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Nonclinical toxicology assessments support the chronic safety of dapagliflozin , a first-in-class sodium-glucose_cotransporter_2 inhibitor .
11359455	0	dapsone	130,137	IL-8	4,8	dapsone	IL-8	MESH:D003622	3576	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|release release|compound|END_ENTITY	The IL-8 release from cultured human keratinocytes , mediated by antibodies to bullous pemphigoid autoantigen 180 , is inhibited by dapsone .
15535984	0	daptomycin	64,74	P450	21,25	daptomycin	P450	MESH:D017576	1555	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	An evaluation of the P450 inhibition and induction potential of daptomycin in primary human hepatocytes .
23439604	0	darapladib	10,20	lipoprotein-associated_phospholipase_A2	31,70	darapladib	lipoprotein-associated phospholipase A2	MESH:C529040	7941	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	Effect of darapladib on plasma lipoprotein-associated_phospholipase_A2 activity in Japanese dyslipidemic patients , with exploratory analysis of a PLA2G7 gene polymorphism of Val279Phe .
24378325	0	darapladib	30,40	lipoprotein-associated_phospholipase_A2	44,83	darapladib	lipoprotein-associated phospholipase A2	MESH:C529040	7941	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Disposition and metabolism of darapladib , a lipoprotein-associated_phospholipase_A2 inhibitor , in humans .
24586490	0	darapladib	10,20	lipoprotein-associated_phospholipase_A2	64,103	darapladib	lipoprotein-associated phospholipase A2	MESH:C529040	7941	Chemical	Gene	treatment|amod|START_ENTITY Effect|nmod|treatment carotid|nsubj|Effect carotid|dobj|activity activity|amod|END_ENTITY	Effect of darapladib treatment on endarterectomy carotid plaque lipoprotein-associated_phospholipase_A2 activity : a randomized , controlled trial .
21995444	0	darexaban	98,107	factor_Xa	149,158	darexaban	factor Xa	MESH:C569750	2159	Chemical	Gene	benzamide|appos|START_ENTITY benzamide|nmod|inhibitor inhibitor|compound|END_ENTITY	Discovery of N - -LSB- 2-hydroxy-6 - -LRB- 4-methoxybenzamido -RRB- phenyl -RSB- -4 - _ -LRB- 4-methyl-1 ,4 - diazepan-1-yl -RRB- benzamide -LRB- darexaban , YM150 -RRB- as a potent and orally available factor_Xa inhibitor .
22040919	0	darexaban	43,52	factor_Xa	69,78	darexaban	factor Xa	MESH:C569750	2159	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Biochemical and pharmacological profile of darexaban , an oral direct factor_Xa inhibitor .
23167531	0	darexaban	40,49	factor_Xa	72,81	darexaban	factor Xa	MESH:C569750	2159	Chemical	Gene	Absorption|nmod|START_ENTITY Absorption|appos|inhibitor inhibitor|compound|END_ENTITY	Absorption , metabolism and excretion of darexaban -LRB- YM150 -RRB- , a new direct factor_Xa inhibitor in humans .
23929659	0	darexaban	72,81	factor_Xa	98,107	darexaban	factor Xa	MESH:C569750	2159	Chemical	Gene	safety|nmod|START_ENTITY pharmacokinetics|appos|safety pharmacokinetics|appos|inhibitor inhibitor|compound|END_ENTITY	Clinical pharmacokinetics , pharmacodynamics , safety and tolerability of darexaban , an oral direct factor_Xa inhibitor , in healthy Caucasian and Japanese subjects .
26052866	0	darexaban	107,116	factor_Xa	200,209	darexaban	factor Xa	MESH:C569750	2159	Chemical	Gene	safety|nmod|START_ENTITY study|nmod|safety study|dep|inhibitor inhibitor|compound|END_ENTITY	A Phase II , double-blind , randomized , parallel group , dose-finding study of the safety and tolerability of darexaban compared with warfarin in patients with non-valvular atrial_fibrillation : the oral factor_Xa inhibitor for prophylaxis of stroke in atrial_fibrillation study 2 -LRB- OPAL-2 -RRB- .
12795642	0	darglitazone	35,47	CD36	62,66	darglitazone	CD36	MESH:C089948	948	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Fatty_acids modulate the effect of darglitazone on macrophage CD36 expression .
19861974	0	darglitazone	24,36	PPAR-gamma	4,14	darglitazone	PPAR-gamma	MESH:C089948	19016(Tax:10090)	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	The PPAR-gamma agonist , darglitazone , restores acute inflammatory responses to cerebral_hypoxia-ischemia in the diabetic_ob / ob_mouse .
16759917	0	darglitazone	49,61	PPARgamma	30,39	darglitazone	PPARgamma	MESH:C089948	19016(Tax:10090)	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|END_ENTITY	Surface-specific effects of a PPARgamma agonist , darglitazone , on bone in mice .
12775966	0	darusentan	48,58	endothelin_a_receptor	15,36	darusentan	endothelin a receptor	MESH:C107831	24326(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|antagonist antagonist|compound|END_ENTITY	Effects of the endothelin_a_receptor antagonist darusentan on blood pressure and vascular contractility in type 2 diabetic Goto-Kakizaki rats .
21680801	0	dasatinib	137,146	Btk	104,107	dasatinib	Btk	MESH:C488369	12229(Tax:10090)	Chemical	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	KIT-D816V-independent oncogenic signaling in neoplastic cells in systemic mastocytosis : role of Lyn and Btk activation and disruption by dasatinib and bosutinib .
19671763	0	dasatinib	12,21	KIT	36,39	dasatinib	KIT	MESH:C488369	3815	Chemical	Gene	START_ENTITY|nmod|melanoma melanoma|compound|END_ENTITY	Activity of dasatinib against L576P KIT mutant melanoma : molecular , cellular , and clinical correlates .
19383922	0	dasatinib	56,65	SRC	28,31	dasatinib	SRC	MESH:C488369	6714	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	Synergistic activity of the SRC family kinase inhibitor dasatinib and oxaliplatin in colon_carcinoma cells is mediated by oxidative stress .
16230377	0	dasatinib	43,52	Src	14,17	dasatinib	Src	MESH:C488369	6714	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Action of the Src family kinase inhibitor , dasatinib -LRB- BMS-354825 -RRB- , on human prostate_cancer cells .
19010823	0	dasatinib	38,47	Src	14,17	dasatinib	Src	MESH:C488369	6714	Chemical	Gene	kinases|nmod|START_ENTITY kinases|compound|END_ENTITY	Inhibition of Src family kinases with dasatinib blocks migration and invasion of human melanoma cells .
19484755	0	dasatinib	88,97	Src	33,36	dasatinib	Src	MESH:C488369	6714	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|determination determination|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Flow cytometric determination of Src phosphorylation in pediatric patients treated with dasatinib .
19861409	0	dasatinib	44,53	Src	11,14	dasatinib	Src	MESH:C488369	6714	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Effects Effects|nmod|inhibition inhibition|compound|END_ENTITY	Effects of Src kinase inhibition induced by dasatinib in non-small_cell_lung_cancer cell lines treated with cisplatin .
20228840	0	dasatinib	32,41	Src	0,3	dasatinib	Src	MESH:C488369	20779(Tax:10090)	Chemical	Gene	proliferation|compound|START_ENTITY proliferation|compound|END_ENTITY	Src family kinase/abl inhibitor dasatinib suppresses proliferation and enhances differentiation of osteoblasts .
20228840	6	dasatinib	999,1008	Src	1125,1128	dasatinib	Abl	MESH:C488369	11350(Tax:10090)	Chemical	Gene	blocks|compound|START_ENTITY proliferative|nsubj|blocks determine|ccomp|proliferative analyzed|advcl|determine analyzed|dobj|expression expression|nmod|panel panel|nmod|END_ENTITY	To determine how dasatinib blocks proliferative signaling in osteoblasts , we analyzed the expression of a panel of tyrosine kinases , including Src , Lyn , Fyn , Yes and Abl , in osteoblasts .
21810917	0	dasatinib	18,27	Src	123,126	dasatinib	Src	MESH:C488369	6714	Chemical	Gene	trial|nmod|START_ENTITY trial|nmod|patients patients|nmod|metastatic_breast_cancer metastatic_breast_cancer|acl|using using|dobj|biomarkers biomarkers|nmod|inhibition inhibition|compound|END_ENTITY	Phase II trial of dasatinib in patients with metastatic_breast_cancer using real-time pharmacodynamic tissue biomarkers of Src inhibition to escalate dosing .
22586301	0	dasatinib	39,48	Src	23,26	dasatinib	Src	MESH:C488369	6714	Chemical	Gene	growth|compound|START_ENTITY kinase|nmod|growth kinase|nsubj|inhibition inhibition|nmod|END_ENTITY	Targeted inhibition of Src kinase with dasatinib blocks thyroid_cancer growth and metastasis .
23922104	0	dasatinib	61,70	Src	0,3	dasatinib	Src	MESH:C488369	6714	Chemical	Gene	sensitises|compound|START_ENTITY kinases|dobj|sensitises kinases|nsubj|END_ENTITY	Src kinases in chondrosarcoma chemoresistance and migration : dasatinib sensitises to doxorubicin in TP53 mutant cells .
25482620	0	dasatinib	69,78	Src	27,30	dasatinib	Src	MESH:C488369	6714	Chemical	Gene	treatment|compound|START_ENTITY Monitoring|nmod|treatment Monitoring|dobj|dynamics dynamics|nmod|activity activity|compound|END_ENTITY	Monitoring the dynamics of Src activity in response to anti-invasive dasatinib treatment at a subcellular level using dual intravital imaging .
18596745	0	dasatinib	123,132	Tyrosine_kinase	0,15	dasatinib	Tyrosine kinase	MESH:C488369	7294	Chemical	Gene	activity|nmod|START_ENTITY basis|nmod|activity inhibition|dep|basis inhibition|amod|END_ENTITY	Tyrosine_kinase inhibition in diffuse large B-cell_lymphoma : molecular basis for antitumor activity and drug resistance of dasatinib .
21264552	4	dasatinib	971,980	patient	999,1006	dasatinib	BCR-ABL	MESH:C488369	25	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|END_ENTITY	Consistent with the in vitro data , the clone with K294RGG mutation was eliminated by the dasatinib treatment in this patient .
21640744	0	daunorubicin	35,47	AKR1B10	0,7	daunorubicin	AKR1B10	MESH:D003630	57016	Chemical	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	AKR1B10 induces cell resistance to daunorubicin and idarubicin by reducing C13_ketonic group .
11703319	0	daunorubicin	62,74	Breast_cancer_resistance_protein	0,32	daunorubicin	Breast cancer resistance protein	MESH:D003630	9429	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Breast_cancer_resistance_protein expression and resistance to daunorubicin in blast cells from patients with acute_myeloid_leukaemia .
18493867	0	daunorubicin	92,104	Granulocyte_colony_stimulating_factor	0,37	daunorubicin	Granulocyte colony stimulating factor	MESH:D003630	1440	Chemical	Gene	increases|nmod|START_ENTITY increases|nsubj|END_ENTITY	Granulocyte_colony_stimulating_factor increases drug resistance of leukaemic blast cells to daunorubicin .
11369136	0	daunorubicin	51,63	MDR1	26,30	daunorubicin	MDR1	MESH:D003630	18669(Tax:10090)	Chemical	Gene	expressing|nmod|START_ENTITY expressing|nsubj|Induction Induction|nmod|apoptosis apoptosis|nmod|END_ENTITY	Induction of apoptosis in MDR1 expressing cells by daunorubicin with combinations of suboptimal concentrations of P-glycoprotein modulators .
15994288	0	daunorubicin	60,72	MDR1	17,21	daunorubicin	MDR1	MESH:D003630	5243	Chemical	Gene	PSC-833|nmod|START_ENTITY value|amod|PSC-833 value|nmod|agent agent|compound|END_ENTITY	The value of the MDR1 reversal agent PSC-833 in addition to daunorubicin and cytarabine in the treatment of elderly patients with previously untreated acute_myeloid_leukemia -LRB- AML -RRB- , in relation to MDR1 status at diagnosis .
15994288	0	daunorubicin	60,72	MDR1	196,200	daunorubicin	MDR1	MESH:D003630	5243	Chemical	Gene	PSC-833|nmod|START_ENTITY value|amod|PSC-833 value|nmod|relation relation|nmod|status status|nummod|END_ENTITY	The value of the MDR1 reversal agent PSC-833 in addition to daunorubicin and cytarabine in the treatment of elderly patients with previously untreated acute_myeloid_leukemia -LRB- AML -RRB- , in relation to MDR1 status at diagnosis .
23252945	0	daunorubicin	26,38	MDR1	115,119	daunorubicin	MDR1	MESH:D003630	5243	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Idarubicin is superior to daunorubicin in remission induction of de novo acute_myeloid_leukemia patients with high MDR1 expression .
8487584	0	daunorubicin	23,35	MDR1	98,102	daunorubicin	MDR1	MESH:D003630	5243	Chemical	Gene	accumulation|compound|START_ENTITY Effect|nmod|accumulation Effect|nmod|cells cells|nmod|levels levels|nmod|expression expression|compound|END_ENTITY	Effect of verapamil on daunorubicin accumulation in human leukemic cells with different levels of MDR1 gene expression .
26861753	0	daunorubicin	95,107	OCT1	37,41	daunorubicin	OCT1	MESH:D003630	6580	Chemical	Gene	uptake|nmod|START_ENTITY mediates|dobj|uptake mediates|nsubj|END_ENTITY	The human organic cation transporter OCT1 mediates high affinity uptake of the anticancer drug daunorubicin .
11027568	0	daunorubicin	33,45	P-glycoprotein	62,76	daunorubicin	P-glycoprotein	MESH:D003630	5243	Chemical	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Cholesterol interaction with the daunorubicin binding site of P-glycoprotein .
7912204	0	daunorubicin	36,48	P-glycoprotein	12,26	daunorubicin	P-glycoprotein	MESH:D003630	5243	Chemical	Gene	transport|compound|START_ENTITY mediated|dobj|transport mediated|nsubj|END_ENTITY	Cooperative P-glycoprotein mediated daunorubicin transport into DNA-loaded plasma membrane vesicles .
8586906	0	daunorubicin	14,26	P-glycoprotein	57,71	daunorubicin	P-glycoprotein	MESH:D003630	5243	Chemical	Gene	accumulation|compound|START_ENTITY accumulation|nmod|END_ENTITY	Modulation of daunorubicin intracellular accumulation in P-glycoprotein expressing MCF-7 human breast_adenocarcinoma cells by thermosensitive-liposome encapsulation and hyperthermia .
1008838	0	daunorubicin	14,26	aldehyde_reductase	54,72	daunorubicin	aldehyde reductase	MESH:D003630	116463(Tax:10116)	Chemical	Gene	Metabolism|nmod|START_ENTITY Metabolism|nmod|END_ENTITY	Metabolism of daunorubicin by a barbiturate-sensitive aldehyde_reductase from rat liver .
11498841	0	daunorubicin	62,74	interleukin-3	96,109	daunorubicin	interleukin-3	MESH:D003630	3562	Chemical	Gene	START_ENTITY|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Study on the sensitization of acute_myeloid_leukemia cell to daunorubicin by recombinant human interleukin-3 -RSB- .
12410571	0	daunorubicin	63,75	mdr1	95,99	daunorubicin	mdr1	MESH:D003630	5243	Chemical	Gene	acute_lymphoblastic_leukemia|nmod|START_ENTITY Resistance|nmod|acute_lymphoblastic_leukemia mediated|nsubjpass|Resistance mediated|nmod|expression expression|amod|END_ENTITY	Resistance of bcr-abl-positive acute_lymphoblastic_leukemia to daunorubicin is not mediated by mdr1 gene expression .
21187093	0	daunorubicin	39,51	miR-21	15,21	daunorubicin	miR-21	MESH:D003630	406991	Chemical	Gene	resistance|acl|START_ENTITY END_ENTITY|nmod|resistance	Involvement of miR-21 in resistance to daunorubicin by regulating PTEN expression in the leukaemia K562 cell line .
10215318	0	deaminoneuraminic_acid	92,114	megalin	18,25	deaminoneuraminic acid	megalin	CHEBI:71429	29216(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification of megalin as the sole rat kidney sialoglycoprotein containing poly alpha2 ,8 deaminoneuraminic_acid .
12023534	0	debrisoquine	19,31	CYP1A1	41,47	debrisoquine	CYP1A1	MESH:D003647	1543	Chemical	Gene	4-Hydroxylation|nmod|START_ENTITY 4-Hydroxylation|nmod|END_ENTITY	4-Hydroxylation of debrisoquine by human CYP1A1 and its inhibition by quinidine and quinine .
7909223	0	debrisoquine	68,80	CYP2D6	94,100	debrisoquine	CYP2D6	MESH:D003647	1565	Chemical	Gene	hydroxylase|amod|START_ENTITY hydroxylase|appos|END_ENTITY	The demethylenation of methylenedioxymethamphetamine -LRB- `` ecstasy '' -RRB- by debrisoquine hydroxylase -LRB- CYP2D6 -RRB- .
22342776	0	debrisoquine	36,48	OCT1	122,126	debrisoquine	OCT1	MESH:D003647	6580	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	The prototypic pharmacogenetic drug debrisoquine is a substrate of the genetically polymorphic organic cation transporter OCT1 .
7875180	0	debrizoquine	51,63	CYP2D6	75,81	debrizoquine	CYP2D6	null	1565	Chemical	Gene	polymorphism|compound|START_ENTITY polymorphism|appos|END_ENTITY	Metoprolol alpha-hydroxylation is a poor probe for debrizoquine oxidation -LRB- CYP2D6 -RRB- polymorphism in Jordanians .
8615854	0	decahydroisoquinoline-3-carboxylic_acid_monohydrate	11,62	CA2	119,122	decahydroisoquinoline-3-carboxylic acid monohydrate	CA2	null	54231(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|responses responses|compound|END_ENTITY	Effects of decahydroisoquinoline-3-carboxylic_acid_monohydrate , a novel AMPA receptor antagonist , on glutamate-induced CA2 + responses and neurotoxicity in rat cortical and cerebellar granule neurons .
17186472	0	decaprenyl_diphosphate	60,82	PDSS2	103,108	decaprenyl diphosphate	PDSS2	CHEBI:53043	57107	Chemical	Gene	START_ENTITY|dobj|synthase synthase|appos|END_ENTITY	Leigh_syndrome with nephropathy and CoQ10_deficiency due to decaprenyl_diphosphate synthase subunit 2 -LRB- PDSS2 -RRB- mutations .
22522773	0	decitabine	24,34	AQP5	45,49	decitabine	AQP5	MESH:C014347	11830(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	DNA demethylating agent decitabine increases AQP5 expression and restores salivary function .
23504398	0	decitabine	22,32	KRAS	97,101	decitabine	KRAS	MESH:C014347	3845	Chemical	Gene	study|nmod|START_ENTITY END_ENTITY|nsubj|study	A phase I/II study of decitabine in combination with panitumumab in patients with wild-type -LRB- wt -RRB- KRAS metastatic colorectal_cancer .
24002123	0	decitabine	75,85	NXF2	28,32	decitabine	NXF2	MESH:C014347	56001	Chemical	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	The cancer - testis antigen NXF2 is activated by the hypomethylating agent decitabine in acute_leukemia cells in vitro and in vivo .
18718068	0	decitabine	11,21	SKM-1	68,73	decitabine	SKM-1	MESH:C014347	6329	Chemical	Gene	Effect|nmod|START_ENTITY combined|nsubj|Effect combined|nmod|END_ENTITY	-LSB- Effect of decitabine combined with Trichostatin_A on MDS cell line SKM-1 in vitro -RSB- .
23046813	0	decitabine	28,38	TRAIL	53,58	decitabine	TRAIL	MESH:C014347	8743	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|pathway pathway|amod|END_ENTITY	The DNA demethylating agent decitabine activates the TRAIL pathway and induces apoptosis in acute_myeloid_leukemia .
23178755	0	decitabine	36,46	miR-29b	81,88	decitabine	miR-29b	MESH:C014347	407024	Chemical	Gene	activity|nmod|START_ENTITY activity|nmod|END_ENTITY	Increased anti-leukemic activity of decitabine via AR-42-induced upregulation of miR-29b : a novel epigenetic-targeting approach in acute_myeloid_leukemia .
21389625	0	decursin	22,30	Nrf2	141,145	decursin	Nrf2	MESH:C101278	83619(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|role role|nmod|END_ENTITY	Protective effects of decursin and decursinol_angelate against amyloid b-protein-induced oxidative stress in the PC12 cell line : the role of Nrf2 and antioxidant enzymes .
20110177	0	deferasirox	59,70	Cystatin_C	0,10	deferasirox	Cystatin C	MESH:C415250	1471	Chemical	Gene	treatment|compound|START_ENTITY levels|nmod|treatment levels|amod|END_ENTITY	Cystatin_C levels in patients with beta-thalassemia during deferasirox treatment .
22993609	0	deferoxamine	100,112	vascular_endothelial_growth_factor	54,88	deferoxamine	vascular endothelial growth factor	MESH:D003676	7422	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Gemcitabine and paclitaxel suppress the production of vascular_endothelial_growth_factor induced by deferoxamine in human non-small_cell_lung_cancer A549 cells .
16769582	0	defibrotide	152,163	antithrombin_III	135,151	defibrotide	antithrombin III	MESH:C036901	462	Chemical	Gene	therapy|amod|START_ENTITY END_ENTITY|dep|therapy	Hepatic_veno-occlusive_disease in pediatric stem cell transplantation : impact of pre-emptive antithrombin_III replacement and combined antithrombin_III / defibrotide therapy .
9270009	0	deguelin	51,59	ornithine_decarboxylase	14,37	deguelin	ornithine decarboxylase	MESH:C107676	18263(Tax:10090)	Chemical	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Regulation of ornithine_decarboxylase induction by deguelin , a natural product cancer chemopreventive agent .
22226709	0	dehydrin	18,26	tas14	27,32	dehydrin	tas14	null	544056(Tax:4081)	Chemical	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Overexpression of dehydrin tas14 gene improves the osmotic stress imposed by drought and salinity in tomato .
8980494	0	dehydrin	17,25	tas14	26,31	dehydrin	tas14	null	544056(Tax:4081)	Chemical	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Structure of the dehydrin tas14 gene of tomato and its developmental and environmental regulation in transgenic tobacco .
21420488	0	dehydroalanine	58,72	GPX1	91,95	dehydroalanine	GPX1	CHEBI:17123	14775(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	Knockout of SOD1 promotes conversion of selenocysteine to dehydroalanine in murine hepatic GPX1 protein .
15374623	0	dehydroaltenusin	15,31	DNA_polymerase_alpha	51,71	dehydroaltenusin	DNA polymerase alpha	MESH:C095645	5422	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	The effects of dehydroaltenusin , a novel mammalian DNA_polymerase_alpha inhibitor , on cell proliferation and cell cycle progression .
15388163	0	dehydroaltenusin	34,50	DNA_polymerase_alpha	86,106	dehydroaltenusin	DNA polymerase alpha	MESH:C095645	5422	Chemical	Gene	elucidation|nmod|START_ENTITY elucidation|appos|inhibitor inhibitor|nmod|END_ENTITY	Precise structural elucidation of dehydroaltenusin , a specific inhibitor of mammalian DNA_polymerase_alpha .
17118336	0	dehydroaltenusin	22,38	DNA_polymerase_alpha	74,94	dehydroaltenusin	DNA polymerase alpha	MESH:C095645	5422	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|inhibitor inhibitor|nmod|END_ENTITY	Anti-tumor effects of dehydroaltenusin , a specific inhibitor of mammalian DNA_polymerase_alpha .
19020778	0	dehydroaltenusin	77,93	DNA_polymerase_alpha	108,128	dehydroaltenusin	DNA polymerase alpha	MESH:C095645	5422	Chemical	Gene	derivative|nmod|START_ENTITY effect|appos|derivative effect|nmod|END_ENTITY	The specific inhibitory effect of demethoxydehydroaltenusin , a derivative of dehydroaltenusin , on mammalian DNA_polymerase_alpha .
19767211	0	dehydroaltenusin	50,66	DNA_polymerase_alpha	92,112	dehydroaltenusin	DNA polymerase alpha	MESH:C095645	5422	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	Synthesis and structure-activity relationships of dehydroaltenusin derivatives as selective DNA_polymerase_alpha inhibitors .
21621509	0	dehydroascorbic_acid	52,72	glucose_transporter-2	4,25	dehydroascorbic acid	glucose transporter-2	MESH:D003683	25351(Tax:10116)	Chemical	Gene	transporter|amod|START_ENTITY transporter|nsubj|END_ENTITY	The glucose_transporter-2 -LRB- GLUT2 -RRB- is a low affinity dehydroascorbic_acid transporter .
10428990	0	dehydrocholesterols	66,85	cholesterol_7alpha-hydroxylase	89,119	dehydrocholesterols	cholesterol 7alpha-hydroxylase	MESH:D003684	25428(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activities activities|amod|END_ENTITY	Bile_acid synthesis in the Smith-Lemli-Opitz_syndrome : effects of dehydrocholesterols on cholesterol_7alpha-hydroxylase and 27-hydroxylase activities in rat liver .
25261737	0	dehydrodiconiferyl_alcohol	47,73	heme_oxygenase-1	16,32	dehydrodiconiferyl alcohol	heme oxygenase-1	MESH:C080686	15368(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Upregulation of heme_oxygenase-1 expression by dehydrodiconiferyl_alcohol -LRB- DHCA -RRB- through the AMPK-Nrf2 dependent pathway .
7614686	0	dehydroepiandrosterone	87,109	3-hydroxy-3-methylglutaryl-CoA_reductase	14,54	dehydroepiandrosterone	3-hydroxy-3-methylglutaryl-CoA reductase	MESH:D003687	25675(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Inhibition of 3-hydroxy-3-methylglutaryl-CoA_reductase activity and gene expression by dehydroepiandrosterone in preneoplastic liver nodules .
2993747	0	dehydroepiandrosterone	32,54	ACTH	10,14	dehydroepiandrosterone	ACTH	MESH:D003687	5443	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of ACTH and prolactin on dehydroepiandrosterone , its sulfate_ester and cortisol production by normal and tumorous human adrenocortical cells .
24622829	0	dehydroepiandrosterone	10,32	BDNF	89,93	dehydroepiandrosterone	BDNF	MESH:D003687	24225(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of dehydroepiandrosterone -LRB- DHEA -RRB- on memory and brain_derived_neurotrophic_factor -LRB- BDNF -RRB- in a rat model of vascular_dementia .
10575002	0	dehydroepiandrosterone	20,42	CYP1A1	52,58	dehydroepiandrosterone	CYP1A1	MESH:D003687	1543	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	The steroid hormone dehydroepiandrosterone inhibits CYP1A1 expression in vitro by a post-transcriptional mechanism .
11950789	0	dehydroepiandrosterone	33,55	CYP3A	13,18	dehydroepiandrosterone	CYP3A	MESH:D003687	13112(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Induction of CYP3A expression by dehydroepiandrosterone : involvement of the pregnane_X_receptor .
6273142	0	dehydroepiandrosterone	40,62	DHEA-S	84,90	dehydroepiandrosterone	DHEA-S	MESH:D003687	6822	Chemical	Gene	secretion|nmod|START_ENTITY secretion|appos|sulfate sulfate|appos|END_ENTITY	Effect of prolactin on the secretion of dehydroepiandrosterone -LRB- DHEA -RRB- , its sulfate -LRB- DHEA-S -RRB- , and cortisol by the human fetal adrenal in vitro .
2956668	0	dehydroepiandrosterone	13,35	G-6-PD	39,45	dehydroepiandrosterone	G-6-PD	MESH:D003687	2539	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Influence of dehydroepiandrosterone on G-6-PD activity and 3H-thymidine uptake of human lymphocytes in vitro .
12065890	0	dehydroepiandrosterone	38,60	GnRH	121,125	dehydroepiandrosterone	GnRH	MESH:D003687	2796	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|release release|appos|END_ENTITY	A role for hypothalamic astrocytes in dehydroepiandrosterone and estradiol regulation of gonadotropin-releasing_hormone -LRB- GnRH -RRB- release by GnRH neurons .
12065890	0	dehydroepiandrosterone	38,60	GnRH	138,142	dehydroepiandrosterone	GnRH	MESH:D003687	2796	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|release release|nmod|END_ENTITY	A role for hypothalamic astrocytes in dehydroepiandrosterone and estradiol regulation of gonadotropin-releasing_hormone -LRB- GnRH -RRB- release by GnRH neurons .
12782399	0	dehydroepiandrosterone	14,36	GnRH	62,66	dehydroepiandrosterone	GnRH	MESH:D003687	25194(Tax:10116)	Chemical	Gene	Evidence|dep|START_ENTITY inhibits|nsubj|Evidence inhibits|dobj|expression expression|amod|END_ENTITY	Evidence that dehydroepiandrosterone , DHEA , directly inhibits GnRH gene expression in GT1-7 hypothalamic neurons .
7651895	0	dehydroepiandrosterone	11,33	GnRH	44,48	dehydroepiandrosterone	GnRH	MESH:D003687	25194(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effects of dehydroepiandrosterone -LRB- DHEA -RRB- on GnRH gene expression in the rat brain as studied by in situ hybridization .
18042734	0	dehydroepiandrosterone	102,124	SULT2A1	143,150	dehydroepiandrosterone	SULT2A1	MESH:D003687	6822	Chemical	Gene	sulfotransferase|compound|START_ENTITY sulfotransferase|appos|END_ENTITY	Identification and characterization of two amino_acids critical for the substrate inhibition of human dehydroepiandrosterone sulfotransferase -LRB- SULT2A1 -RRB- .
24909515	0	dehydroepiandrosterone	40,62	SULT2A1	81,88	dehydroepiandrosterone	SULT2A1	MESH:D003687	6822	Chemical	Gene	sulfotransferase|amod|START_ENTITY sulfotransferase|appos|END_ENTITY	Dopamine_D1_receptor activation induces dehydroepiandrosterone sulfotransferase -LRB- SULT2A1 -RRB- in HepG2 cells .
17276571	0	dehydroepiandrosterone	80,102	constitutive_androstane_receptor	6,38	dehydroepiandrosterone	constitutive androstane receptor	MESH:D003687	9970	Chemical	Gene	sulfotransferase|compound|START_ENTITY induction|nmod|sulfotransferase mediated|dobj|induction mediated|nsubj|END_ENTITY	Human constitutive_androstane_receptor mediated methotrexate induction of human dehydroepiandrosterone sulfotransferase -LRB- hSULT2A1 -RRB- .
17665393	0	dehydroepiandrosterone	13,35	cysteine-rich_secretory_protein_3	59,92	dehydroepiandrosterone	cysteine-rich secretory protein 3	MESH:D003687	10321	Chemical	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Low salivary dehydroepiandrosterone and androgen-regulated cysteine-rich_secretory_protein_3 levels in Sj gren 's _ syndrome .
9806358	0	dehydroepiandrosterone	11,33	estrogen_receptor	56,73	dehydroepiandrosterone	estrogen receptor	MESH:D003687	2099	Chemical	Gene	Studies|nmod|START_ENTITY Studies|nmod|END_ENTITY	Studies of dehydroepiandrosterone -LRB- DHEA -RRB- with the human estrogen_receptor in yeast .
12065890	0	dehydroepiandrosterone	38,60	gonadotropin-releasing_hormone	89,119	dehydroepiandrosterone	gonadotropin-releasing hormone	MESH:D003687	2796	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|release release|amod|END_ENTITY	A role for hypothalamic astrocytes in dehydroepiandrosterone and estradiol regulation of gonadotropin-releasing_hormone -LRB- GnRH -RRB- release by GnRH neurons .
6445673	0	dehydroepiandrosterone	6,28	growth_hormone	67,81	dehydroepiandrosterone	growth hormone	MESH:D003687	2688	Chemical	Gene	START_ENTITY|nmod|therapy therapy|compound|END_ENTITY	Serum dehydroepiandrosterone -LRB- DHA -RRB- and sulphate -LRB- DHAS -RRB- after acute growth_hormone therapy .
17163485	0	dehydroepiandrosterone	65,87	hSULT2A1	106,114	dehydroepiandrosterone	hSULT2A1	MESH:D003687	6822	Chemical	Gene	sulfotransferase|compound|START_ENTITY sulfotransferase|appos|END_ENTITY	Nuclear receptor interactions in methotrexate induction of human dehydroepiandrosterone sulfotransferase -LRB- hSULT2A1 -RRB- .
17276571	0	dehydroepiandrosterone	80,102	hSULT2A1	121,129	dehydroepiandrosterone	hSULT2A1	MESH:D003687	6822	Chemical	Gene	sulfotransferase|compound|START_ENTITY sulfotransferase|appos|END_ENTITY	Human constitutive_androstane_receptor mediated methotrexate induction of human dehydroepiandrosterone sulfotransferase -LRB- hSULT2A1 -RRB- .
23352501	0	dehydroepiandrosterone	61,83	hSULT2A1	102,110	dehydroepiandrosterone	hSULT2A1	MESH:D003687	6822	Chemical	Gene	sulfotransferase|compound|START_ENTITY sulfotransferase|appos|END_ENTITY	Liver X receptor alpha mediated genistein induction of human dehydroepiandrosterone sulfotransferase -LRB- hSULT2A1 -RRB- in Hep G2 cells .
20887595	0	dehydroepiandrosterone	28,50	insulin	67,74	dehydroepiandrosterone	insulin	MESH:D003687	3630	Chemical	Gene	levels|nmod|START_ENTITY levels|appos|independent independent|nmod|resistance resistance|compound|END_ENTITY	Lower circulating levels of dehydroepiandrosterone , independent of insulin resistance , is an important determinant of severity of non-alcoholic_steatohepatitis in Japanese patients .
21112864	0	dehydroepiandrosterone	14,36	insulin	40,47	dehydroepiandrosterone	insulin	MESH:D003687	3630	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|resistance resistance|compound|END_ENTITY	The effect of dehydroepiandrosterone on insulin resistance in patients with impaired_glucose_tolerance .
7852539	0	dehydroepiandrosterone	54,76	insulin	11,18	dehydroepiandrosterone	insulin	MESH:D003687	3630	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|reduction reduction|compound|END_ENTITY	Effects of insulin reduction with benfluorex on serum dehydroepiandrosterone -LRB- DHEA -RRB- , DHEA_sulfate , and blood pressure in hypertensive middle-aged and elderly men .
7929824	0	dehydroepiandrosterone	83,105	insulin	23,30	dehydroepiandrosterone	insulin	MESH:D003687	3630	Chemical	Gene	rate|nmod|START_ENTITY increase|dobj|rate action|acl|increase action|nmod|END_ENTITY	Sex-specific action of insulin to acutely increase the metabolic clearance rate of dehydroepiandrosterone in humans .
8238089	0	dehydroepiandrosterone	65,87	insulin	29,36	dehydroepiandrosterone	insulin	MESH:D003687	3630	Chemical	Gene	diabetes|nmod|START_ENTITY resistance|nmod|diabetes resistance|compound|END_ENTITY	Case report : amelioration of insulin resistance in diabetes with dehydroepiandrosterone .
9059564	0	dehydroepiandrosterone	37,59	insulin	10,17	dehydroepiandrosterone	insulin	MESH:D003687	3630	Chemical	Gene	levels|nmod|START_ENTITY END_ENTITY|nmod|levels	Effect of insulin on serum levels of dehydroepiandrosterone metabolites in men .
10841075	0	dehydroepiandrosterone	50,72	interleukin-10	21,35	dehydroepiandrosterone	interleukin-10	MESH:D003687	16153(Tax:10090)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|production production|amod|END_ENTITY	Regulation of murine interleukin-10 production by dehydroepiandrosterone .
15476247	0	dehydroepiandrosterone	103,125	interleukin-1beta	140,157	dehydroepiandrosterone	interleukin-1beta	MESH:D003687	16176(Tax:10090)	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|nmod|END_ENTITY	Severity of murine collagen-induced_arthritis correlates with increased CYP7B activity : enhancement of dehydroepiandrosterone metabolism by interleukin-1beta .
16677716	0	dehydroepiandrosterone	10,32	interleukin-6	63,76	dehydroepiandrosterone	interleukin-6	MESH:D003687	403985(Tax:9615)	Chemical	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Effect of dehydroepiandrosterone on lipopolysaccharide-induced interleukin-6 production in DH82 cultured canine macrophage cells .
9626133	0	dehydroepiandrosterone	6,28	interleukin-6	90,103	dehydroepiandrosterone	interleukin-6	MESH:D003687	3569	Chemical	Gene	correlated|nsubjpass|START_ENTITY correlated|nmod|END_ENTITY	Serum dehydroepiandrosterone -LRB- DHEA -RRB- and DHEA_sulfate are negatively correlated with serum interleukin-6 -LRB- IL-6 -RRB- , and DHEA inhibits IL-6 secretion from mononuclear cells in man in vitro : possible link between endocrinosenescence and immunosenescence .
18307051	0	dehydroepiandrosterone	10,32	monoamine_oxidase	43,60	dehydroepiandrosterone	monoamine oxidase	MESH:D003687	29253(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	Effect of dehydroepiandrosterone -LRB- DHEA -RRB- on monoamine_oxidase activity , lipid peroxidation and lipofuscin_accumulation in aging rat brain regions .
19772862	0	dehydroepiandrosterone	21,43	monoamine_oxidase	53,70	dehydroepiandrosterone	monoamine oxidase	MESH:D003687	29253(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nsubj|effect	Inhibitory effect of dehydroepiandrosterone on brain monoamine_oxidase activity : in vivo and in vitro studies .
6273142	0	dehydroepiandrosterone	40,62	prolactin	10,19	dehydroepiandrosterone	prolactin	MESH:D003687	5617	Chemical	Gene	secretion|nmod|START_ENTITY END_ENTITY|nmod|secretion	Effect of prolactin on the secretion of dehydroepiandrosterone -LRB- DHEA -RRB- , its sulfate -LRB- DHEA-S -RRB- , and cortisol by the human fetal adrenal in vitro .
25760536	0	dehydroepiandrosterone	27,49	rSULT2A1	68,76	dehydroepiandrosterone	rSULT2A1	MESH:D003687	24912(Tax:10116)	Chemical	Gene	sulfotransferase|amod|START_ENTITY sulfotransferase|appos|END_ENTITY	Exogenous dopamine induces dehydroepiandrosterone sulfotransferase -LRB- rSULT2A1 -RRB- in rat liver and changes the pharmacokinetic profile of moxifloxacin in rats .
8704732	0	dehydroepiandrosterone	11,33	tyrosine_hydroxylase	91,111	dehydroepiandrosterone	tyrosine hydroxylase	MESH:D003687	25085(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of dehydroepiandrosterone -LRB- DHEA -RRB- on pituitary prolactin and arcuate nucleus neuron tyrosine_hydroxylase mRNA levels in the rat .
12915699	0	dehydroepiandrosterone-sulfate	11,41	Apo_E	49,54	dehydroepiandrosterone-sulfate	Apo E	MESH:D019314	348	Chemical	Gene	START_ENTITY|nmod|genotype genotype|compound|END_ENTITY	Effects of dehydroepiandrosterone-sulfate on the Apo_E genotype influence on plasma lipid levels in prepubertal children .
9132172	0	dehydroepiandrosterone_sulfate	49,79	Acyl-CoA_oxidase	29,45	dehydroepiandrosterone sulfate	Acyl-CoA oxidase	MESH:D019314	50681(Tax:10116)	Chemical	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	Transcriptional induction of Acyl-CoA_oxidase by dehydroepiandrosterone_sulfate in cultured rat hepatocytes .
16019179	0	dehydroepiandrosterone_sulfate	31,61	DHEA-S	63,69	dehydroepiandrosterone sulfate	DHEA-S	MESH:D019314	6822	Chemical	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Aging and season affect plasma dehydroepiandrosterone_sulfate -LRB- DHEA-S -RRB- levels in a primate .
19732820	0	dehydroepiandrosterone_sulfate	35,65	DHEA-S	67,73	dehydroepiandrosterone sulfate	DHEA-S	MESH:D019314	6822	Chemical	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Lack of association between plasma dehydroepiandrosterone_sulfate -LRB- DHEA-S -RRB- levels and depression in hemodialysis patients : a cross-sectional study .
2529264	1	dehydroepiandrosterone_sulfate	167,197	DHEA-S	199,205	dehydroepiandrosterone sulfate	DHEA-S	MESH:D019314	6822	Chemical	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	We previously demonstrated a progressive decline in serum dehydroepiandrosterone_sulfate -LRB- DHEA-S -RRB- levels in women during a hyperinsulinemic-euglycemic_clamp .
22153766	0	dehydroepiandrosterone_sulfate	16,46	DHEAS	48,53	dehydroepiandrosterone sulfate	DHEAS	MESH:D019314	6822	Chemical	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Serum levels of dehydroepiandrosterone_sulfate -LRB- DHEAS -RRB- in ocular_toxoplasmosis .
6219334	0	dehydroepiandrosterone_sulfate	32,62	DHEAS	64,69	dehydroepiandrosterone sulfate	DHEAS	MESH:D019314	6822	Chemical	Gene	suppression|nmod|START_ENTITY suppression|appos|END_ENTITY	Disproportionate suppression of dehydroepiandrosterone_sulfate -LRB- DHEAS -RRB- in treated patients with congenital_adrenal_hyperplasia_due_to_21-hydroxylase_deficiency .
17141281	0	dehydroepiandrosterone_sulfate	13,43	dopamine_D1_and_sigma-1_receptor	129,161	dehydroepiandrosterone sulfate	dopamine D1 and sigma-1 receptor	MESH:D019314	29336(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|activation activation|nmod|END_ENTITY	Neurosteroid dehydroepiandrosterone_sulfate enhances spontaneous glutamate release in rat prelimbic cortex through activation of dopamine_D1_and_sigma-1_receptor .
11836304	0	dehydroepiandrosterone_sulfate	18,48	insulin	73,80	dehydroepiandrosterone sulfate	insulin	MESH:D019314	3630	Chemical	Gene	Genetics|nmod|START_ENTITY Genetics|nmod|END_ENTITY	Genetics of serum dehydroepiandrosterone_sulfate and its relationship to insulin in a population-based cohort of twin subjects .
2950000	0	dehydroepiandrosterone_sulfate	15,45	insulin	70,77	dehydroepiandrosterone sulfate	insulin	MESH:D019314	3630	Chemical	Gene	levels|compound|START_ENTITY levels|nmod|patients patients|nmod|resistance resistance|compound|END_ENTITY	Elevated serum dehydroepiandrosterone_sulfate levels in patients with insulin resistance , hirsutism , and acanthosis nigricans .
8126125	0	dehydroepiandrosterone_sulfate	68,98	insulin	38,45	dehydroepiandrosterone sulfate	insulin	MESH:D019314	3630	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|reduction reduction|acl|circulating circulating|dobj|END_ENTITY	Effects of a reduction in circulating insulin by metformin on serum dehydroepiandrosterone_sulfate in nondiabetic men .
8307110	0	dehydroepiandrosterone_sulfate	80,110	insulin	8,15	dehydroepiandrosterone sulfate	insulin	MESH:D019314	3630	Chemical	Gene	levels|amod|START_ENTITY plasma|dobj|levels plasma|nsubj|treatment treatment|compound|END_ENTITY	Chronic insulin treatment , but not chronic ACTH administration increases plasma dehydroepiandrosterone_sulfate levels in adolescent male rats .
9225839	0	dehydroepiandrosterone_sulfate	20,50	insulin	74,81	dehydroepiandrosterone sulfate	insulin	MESH:D019314	3630	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|compound|END_ENTITY	Effects of aging on dehydroepiandrosterone_sulfate in relation to fasting insulin levels and body composition assessed by bioimpedance analysis .
11408725	0	dehydroepiandrosterone_sulfate	78,108	insulin-like_growth_factor_I	7,35	dehydroepiandrosterone sulfate	insulin-like growth factor I	MESH:D019314	3479	Chemical	Gene	levels|compound|START_ENTITY relation|nmod|levels levels|dep|relation levels|compound|END_ENTITY	Plasma insulin-like_growth_factor_I levels in the elderly : relation to plasma dehydroepiandrosterone_sulfate levels , nutritional status , health and mortality .
12521235	0	dehydroepiandrosterone_sulfate	157,187	sex_hormone-binding_globulin	120,148	dehydroepiandrosterone sulfate	sex hormone-binding globulin	MESH:D019314	6462	Chemical	Gene	lutropin|appos|START_ENTITY lutropin|amod|END_ENTITY	Reference ranges for serum concentrations of lutropin -LRB- LH -RRB- , follitropin -LRB- FSH -RRB- , estradiol -LRB- E2 -RRB- , prolactin , progesterone , sex_hormone-binding_globulin -LRB- SHBG -RRB- , dehydroepiandrosterone_sulfate -LRB- DHEAS -RRB- , cortisol and ferritin in neonates , children and young adults .
8809202	0	dehydroepiandrosterone_sulphate	85,116	DHEAS	118,123	dehydroepiandrosterone sulphate	DHEAS	CHEBI:16814	6822	Chemical	Gene	production|amod|START_ENTITY production|appos|END_ENTITY	Effects of joining peptide -LRB- 1-18 -RRB- and histamine on dehydroepiandrosterone -LRB- DHEA -RRB- and dehydroepiandrosterone_sulphate -LRB- DHEAS -RRB- production of human adrenocortical cells in vitro .
3160207	0	dehydroepiandrosterone_sulphate	36,67	prolactin	25,34	dehydroepiandrosterone sulphate	prolactin	CHEBI:16814	5617	Chemical	Gene	START_ENTITY|nsubj|relationship relationship|nmod|END_ENTITY	The relationship between prolactin , dehydroepiandrosterone_sulphate and testosterone in normally menstruating females .
19020914	0	dehydroergosterol_monohydrate	13,42	sterol_carrier_protein-2	64,88	dehydroergosterol monohydrate	sterol carrier protein-2	null	6342	Chemical	Gene	Structure|nmod|START_ENTITY Structure|nmod|END_ENTITY	Structure of dehydroergosterol_monohydrate and interaction with sterol_carrier_protein-2 .
24083986	0	dehydroglyasperin_C	17,36	MKP-1	47,52	dehydroglyasperin C	MKP-1	MESH:C548688	1843	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Licorice-derived dehydroglyasperin_C increases MKP-1 expression and suppresses inflammation-mediated neurodegeneration .
22578244	0	dehydroglyasperin_C	27,46	heme_oxygenase-1	69,85	dehydroglyasperin C	heme oxygenase-1	MESH:C548688	15368(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Neuroprotective effects of dehydroglyasperin_C through activation of heme_oxygenase-1 in mouse hippocampal cells .
25176057	0	dehydroglyasperin_D	26,45	MLK3	0,4	dehydroglyasperin D	MLK3	MESH:C551630	26403(Tax:10090)	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	MLK3 is a novel target of dehydroglyasperin_D for the reduction in UVB-induced COX-2 expression in vitro and in vivo .
12866358	0	dehydroxymethyl-epoxyquinomicin	37,68	NF-kappa_B	73,83	dehydroxymethyl-epoxyquinomicin	NF-kappa B	MESH:C464444	4790	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Preparation of radioactively labeled dehydroxymethyl-epoxyquinomicin , an NF-kappa_B function inhibitor .
16978829	0	dehydroxymethylepoxyquinomicin	85,115	NF-kappaB	64,73	dehydroxymethylepoxyquinomicin	NF-kappaB	MESH:C464444	18033(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Inhibition of macrophage activation and phagocytosis by a novel NF-kappaB inhibitor , dehydroxymethylepoxyquinomicin .
18760530	0	dehydroxymethylepoxyquinomicin	106,136	NF-kappaB	85,94	dehydroxymethylepoxyquinomicin	NF-kappaB	MESH:C464444	4790	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Growth suppression and apoptosis induction in synovial_sarcoma cell lines by a novel NF-kappaB inhibitor , dehydroxymethylepoxyquinomicin -LRB- DHMEQ -RRB- .
19275643	5	dehydroxymethylepoxyquinomicin	864,894	NF-kappaB	836,845	dehydroxymethylepoxyquinomicin	NF-kappaB	MESH:C464444	4790	Chemical	Gene	DHMEQ|appos|START_ENTITY inhibitor|appos|DHMEQ inhibitor|amod|END_ENTITY	A novel NF-kappaB inhibitor , DHMEQ -LRB- dehydroxymethylepoxyquinomicin -RRB- , inhibits the translocation of NF-kappaB into the nucleus as well as inhibits DNA binding of NF-kappaB components and was shown to be a potent chemo - and immuno-sensitizing agent and in combination with cytotoxic therapeutics resulted in significant reversal of resistance and tumor cell death .
19560263	0	dehydroxymethylepoxyquinomicin	41,71	NF-kappaB	30,39	dehydroxymethylepoxyquinomicin	NF-kappaB	MESH:C464444	4790	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|nmod|END_ENTITY	A small molecule inhibitor of NF-kappaB , dehydroxymethylepoxyquinomicin -LRB- DHMEQ -RRB- , suppresses growth and invasion of nasopharyngeal_carcinoma -LRB- NPC -RRB- cells .
20573582	0	dehydroxymethylepoxyquinomicin	89,119	nuclear_factor-kappaB	56,77	dehydroxymethylepoxyquinomicin	nuclear factor-kappaB	MESH:C464444	4790	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Regulation of human dendritic cells by a novel specific nuclear_factor-kappaB inhibitor , dehydroxymethylepoxyquinomicin .
21869747	0	dehydroxytrichostatin_A	18,41	ATP-binding_cassette_transporter_A1	73,108	dehydroxytrichostatin A	ATP-binding cassette transporter A1	MESH:C568711	11303(Tax:10090)	Chemical	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of dehydroxytrichostatin_A as a novel up-regulator of the ATP-binding_cassette_transporter_A1 -LRB- ABCA1 -RRB- .
1959233	0	delapril	10,18	angiotensin_II	35,49	delapril	angiotensin II	MESH:C047759	24179(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	Effect of delapril on the vascular angiotensin_II release in isolated hind legs of the spontaneously hypertensive rat : evidence for potential relevance of vascular angiotensin_II to the maintenance of hypertension .
7815280	0	delapril_hydrochloride	94,116	ACE	79,82	delapril hydrochloride	ACE	null	24310(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Anti-hypertensive effect of oral controlled-release microspheres containing an ACE inhibitor -LRB- delapril_hydrochloride -RRB- in rats .
2209711	0	delapril_hydrochloride	10,32	angiotensin_II	36,50	delapril hydrochloride	angiotensin II	null	24179(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|release release|amod|END_ENTITY	Effect of delapril_hydrochloride on angiotensin_II release from isolated rat hind legs .
8380215	0	delta-9-tetrahydrocannabinol	22,50	IL-2	54,58	delta-9-tetrahydrocannabinol	IL-2	MESH:D013759	16183(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Contrasting effect of delta-9-tetrahydrocannabinol on IL-2 activity in spleen and lymph node cells of mice of different ages .
1313519	0	delta-9-tetrahydrocannabinol	46,74	growth_hormone	120,134	delta-9-tetrahydrocannabinol	growth hormone	MESH:D013759	81668(Tax:10116)	Chemical	Gene	administration|nmod|START_ENTITY Effect|nmod|administration END_ENTITY|nsubj|Effect	Effect of acute intravenous administration of delta-9-tetrahydrocannabinol on the episodic secretion of immunoassayable growth_hormone in the rat .
8100994	0	delta-aminolaevulinic_acid	13,39	ALAD	41,45	delta-aminolaevulinic acid	ALAD	null	210	Chemical	Gene	Activity|nmod|START_ENTITY Activity|appos|END_ENTITY	-LSB- Activity of delta-aminolaevulinic_acid -LRB- ALAD -RRB- in erythrocytes of patients with chronic_hepatic_porphyria -LRB- porphyria cutanea_tarda -RRB- -RSB- .
16367778	0	delta-aminolaevulinic_acid	25,51	CA1	107,110	delta-aminolaevulinic acid	CA1	null	310218(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|neurons neurons|compound|END_ENTITY	Effects of extracellular delta-aminolaevulinic_acid on sodium currents in acutely isolated rat hippocampal CA1 neurons .
9396727	0	delta-aminolaevulinic_acid	15,41	iron_regulatory_protein_1	78,103	delta-aminolaevulinic acid	iron regulatory protein 1	null	50655(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|nmod|END_ENTITY	Haem precursor delta-aminolaevulinic_acid induces activation of the cytosolic iron_regulatory_protein_1 .
11020479	0	delta-aminolaevulinic_acid	93,119	mitochondrial_benzodiazepine_receptor	19,56	delta-aminolaevulinic acid	mitochondrial benzodiazepine receptor	null	24230(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A key role for the mitochondrial_benzodiazepine_receptor in cellular photosensitisation with delta-aminolaevulinic_acid .
7698013	0	delta-aminolevulinate	37,58	ALAS1	74,79	delta-aminolevulinate	ALAS1	null	211	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Assignment of the human housekeeping delta-aminolevulinate synthase gene -LRB- ALAS1 -RRB- to chromosome band 3p21 .1 by PCR analysis of somatic cell hybrids .
12393610	0	delta-aminolevulinate	69,90	ALAS2	101,106	delta-aminolevulinate	ALAS2	null	11656(Tax:10090)	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	Aberrant iron accumulation and oxidized status of erythroid-specific delta-aminolevulinate synthase -LRB- ALAS2 -RRB- - deficient definitive erythroblasts .
1577484	0	delta-aminolevulinate	30,51	ALAS2	62,67	delta-aminolevulinate	ALAS2	null	212	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	Assignment of human erythroid delta-aminolevulinate synthase -LRB- ALAS2 -RRB- to a distal subregion of band Xp11 .21 by PCR analysis of somatic cell hybrids containing X ; autosome translocations .
7560104	1	delta-aminolevulinate	78,99	ALAS2	110,115	delta-aminolevulinate	ALAS2	null	212	Chemical	Gene	synthase|amod|START_ENTITY gene|amod|synthase gene|appos|END_ENTITY	Missense mutations in the erythroid delta-aminolevulinate synthase -LRB- ALAS2 -RRB- gene in two pyridoxine-responsive patients initially diagnosed with acquired refractory_anemia and ringed sideroblasts .
7949148	0	delta-aminolevulinate	88,109	ALAS2	125,130	delta-aminolevulinate	ALAS2	null	212	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	X-linked_sideroblastic_anemia : identification of the mutation in the erythroid-specific delta-aminolevulinate synthase gene -LRB- ALAS2 -RRB- in the original family described by Cooley .
10403633	0	delta-aminolevulinic_acid	44,69	ALA-D	83,88	delta-aminolevulinic acid	ALA-D	MESH:D000622	210	Chemical	Gene	dehydratase|amod|START_ENTITY dehydratase|appos|END_ENTITY	Environmental lead exposure and activity of delta-aminolevulinic_acid dehydratase -LRB- ALA-D -RRB- in maternal and cord blood .
15141099	0	delta-aminolevulinic_acid	45,70	ALA-D	84,89	delta-aminolevulinic acid	ALA-D	MESH:D000622	210	Chemical	Gene	dehydratase|amod|START_ENTITY exposure|nmod|dehydratase exposure|appos|END_ENTITY	Environmental boron exposure and activity of delta-aminolevulinic_acid dehydratase -LRB- ALA-D -RRB- in a newborn population .
7242022	0	delta-aminolevulinic_acid	21,46	ALA-D	60,65	delta-aminolevulinic acid	ALA-D	MESH:D000622	210	Chemical	Gene	dehydratase|amod|START_ENTITY dehydratase|appos|END_ENTITY	Interferences in the delta-aminolevulinic_acid dehydratase -LRB- ALA-D -RRB- assay .
7624881	0	delta-aminolevulinic_acid	118,143	ALA-D	157,162	delta-aminolevulinic acid	ALA-D	MESH:D000622	25374(Tax:10116)	Chemical	Gene	dehydratase|amod|START_ENTITY growth|nmod|dehydratase growth|dep|END_ENTITY	Effect of treatment with mercury_chloride and lead_acetate during the second stage of rapid postnatal brain growth on delta-aminolevulinic_acid dehydratase -LRB- ALA-D -RRB- activity in brain , liver , kidney and blood of suckling rats .
8510341	6	delta-aminolevulinic_acid	1028,1053	ALA-D	1076,1081	delta-aminolevulinic acid	ALA-D	MESH:D000622	210	Chemical	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	In the workers , the correlation coefficients of ALA-B vs. Pb-B and ALA-B vs. delta-aminolevulinic_acid dehydratase activity -LRB- ALA-D -RRB- were higher than those of urinary concentration of ALA vs. Pb-B and that vs. ALA-D , especially in the moderate Pb-B level -LRB- less than 40 micrograms/dl , n = 35 -RRB- .
11564619	0	delta-aminolevulinic_acid	4,29	ALAD	43,47	delta-aminolevulinic acid	ALAD	MESH:D000622	210	Chemical	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	The delta-aminolevulinic_acid dehydratase -LRB- ALAD -RRB- polymorphism and bone and blood lead levels in community-exposed men : the Normative Aging Study .
12541271	0	delta-aminolevulinic_acid	17,42	ALAD	56,60	delta-aminolevulinic acid	ALAD	MESH:D000622	210	Chemical	Gene	dehydratase|amod|START_ENTITY dehydratase|appos|END_ENTITY	Influence of the delta-aminolevulinic_acid dehydratase -LRB- ALAD -RRB- polymorphism on biomarkers of lead exposure in Turkish storage battery manufacturing workers .
12611663	0	delta-aminolevulinic_acid	2,27	ALAD	41,45	delta-aminolevulinic acid	ALAD	MESH:D000622	210	Chemical	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	A delta-aminolevulinic_acid dehydratase -LRB- ALAD -RRB- polymorphism may modify the relationship of low-level lead exposure to uricemia and renal function : the normative aging study .
12972060	0	delta-aminolevulinic_acid	13,38	ALAD	52,56	delta-aminolevulinic acid	ALAD	MESH:D000622	210	Chemical	Gene	dehydratase|amod|START_ENTITY Influence|nmod|dehydratase Influence|appos|END_ENTITY	Influence of delta-aminolevulinic_acid dehydratase -LRB- ALAD -RRB- polymorphism on the frequency of sister chromatid exchange -LRB- SCE -RRB- and the number of high-frequency cells -LRB- HFCs -RRB- in lymphocytes from lead-exposed workers .
15210182	0	delta-aminolevulinic_acid	27,52	ALAD	66,70	delta-aminolevulinic acid	ALAD	MESH:D000622	101162461	Chemical	Gene	dehydratase|amod|START_ENTITY gene|nmod|dehydratase mutation|nmod|gene mutation|appos|END_ENTITY	A mutation in the gene for delta-aminolevulinic_acid dehydratase -LRB- ALAD -RRB- causes hypochromic_anemia in the medaka , Oryzias_latipes .
16445899	0	delta-aminolevulinic_acid	38,63	ALAD	77,81	delta-aminolevulinic acid	ALAD	MESH:D000622	210	Chemical	Gene	dehydratase|amod|START_ENTITY dehydratase|appos|END_ENTITY	Ethnicity affects the distribution of delta-aminolevulinic_acid dehydratase -LRB- ALAD -RRB- genetic variants .
17823382	0	delta-aminolevulinic_acid	72,97	ALAD	111,115	delta-aminolevulinic acid	ALAD	MESH:D000622	210	Chemical	Gene	dehydratase|amod|START_ENTITY dehydratase|appos|END_ENTITY	Lead burden and psychiatric symptoms and the modifying influence of the delta-aminolevulinic_acid dehydratase -LRB- ALAD -RRB- polymorphism : the VA Normative Aging Study .
19723536	0	delta-aminolevulinic_acid	17,42	ALAD	56,60	delta-aminolevulinic acid	ALAD	MESH:D000622	210	Chemical	Gene	dehydratase|amod|START_ENTITY dehydratase|appos|END_ENTITY	Polymorphisms of delta-aminolevulinic_acid dehydratase -LRB- ALAD -RRB- and peptide_transporter_2 -LRB- PEPT2 -RRB- genes in children with low-level lead exposure .
19766174	0	delta-aminolevulinic_acid	44,69	ALAD	83,87	delta-aminolevulinic acid	ALAD	MESH:D000622	210	Chemical	Gene	dehydratase|amod|START_ENTITY dehydratase|appos|END_ENTITY	Ethnic variation in genotype frequencies of delta-aminolevulinic_acid dehydratase -LRB- ALAD -RRB- .
2061546	0	delta-aminolevulinic_acid	87,112	ALAD	126,130	delta-aminolevulinic acid	ALAD	MESH:D000622	210	Chemical	Gene	START_ENTITY|dobj|activity activity|appos|END_ENTITY	A comparison of the effects of inorganic and alkyllead compounds on human erythrocytic delta-aminolevulinic_acid dehydratase -LRB- ALAD -RRB- activity in vitro .
621966	0	delta-aminolevulinic_acid	25,50	ALAD	64,68	delta-aminolevulinic acid	ALAD	MESH:D000622	25374(Tax:10116)	Chemical	Gene	dehydratase|amod|START_ENTITY dehydratase|dep|END_ENTITY	Developmental changes in delta-aminolevulinic_acid dehydratase -LRB- ALAD -RRB- activity and blood reticulocyte percent in the developing rat .
6838373	0	delta-aminolevulinic_acid	12,37	ALAD	51,55	delta-aminolevulinic acid	ALAD	MESH:D000622	25374(Tax:10116)	Chemical	Gene	dehydratase|amod|START_ENTITY dehydratase|appos|END_ENTITY	Increase of delta-aminolevulinic_acid dehydratase -LRB- ALAD -RRB- in rat erythrocytes in lead_poisoning .
7599513	0	delta-aminolevulinic_acid	47,72	ALAD	86,90	delta-aminolevulinic acid	ALAD	MESH:D000622	474808(Tax:9615)	Chemical	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Whole blood lead concentration and erythrocyte delta-aminolevulinic_acid dehydratase -LRB- ALAD -RRB- activity in selected canine populations in Greece .
8080400	0	delta-aminolevulinic_acid	59,84	ALAD	98,102	delta-aminolevulinic acid	ALAD	MESH:D000622	210	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Lack of association between alcoholism and alleles in the delta-aminolevulinic_acid dehydratase -LRB- ALAD -RRB- gene -RSB- .
9353844	0	delta-aminolevulinic_acid	16,41	ALAD	55,59	delta-aminolevulinic acid	ALAD	MESH:D000622	210	Chemical	Gene	dehydratase|amod|START_ENTITY dehydratase|appos|END_ENTITY	Lead binding to delta-aminolevulinic_acid dehydratase -LRB- ALAD -RRB- in human erythrocytes .
18499231	0	delta-aminolevulinic_acid	27,52	ALAd	66,70	delta-aminolevulinic acid	ALAd	MESH:D000622	210	Chemical	Gene	dehydratase|amod|START_ENTITY dehydratase|appos|END_ENTITY	Metallothioneins -LRB- MTs -RRB- and delta-aminolevulinic_acid dehydratase -LRB- ALAd -RRB- as biomarkers of metal pollution in great tits -LRB- Parus major -RRB- along a pollution gradient .
19723536	0	delta-aminolevulinic_acid	17,42	PEPT2	89,94	delta-aminolevulinic acid	PEPT2	MESH:D000622	6565	Chemical	Gene	dehydratase|amod|START_ENTITY dehydratase|appos|END_ENTITY	Polymorphisms of delta-aminolevulinic_acid dehydratase -LRB- ALAD -RRB- and peptide_transporter_2 -LRB- PEPT2 -RRB- genes in children with low-level lead exposure .
7894023	0	delta-aminolevulinic_acid	114,139	alad	58,62	delta-aminolevulinic acid	alad	MESH:D000622	5727479(Tax:3055)	Chemical	Gene	dehydratase|amod|START_ENTITY enzyme|appos|dehydratase encoding|dobj|enzyme END_ENTITY|xcomp|encoding	Structure and expression of the Chlamydomonas_reinhardtii alad gene encoding the chlorophyll biosynthetic enzyme , delta-aminolevulinic_acid dehydratase -LRB- porphobilinogen synthase -RRB- .
7770514	0	delta-aminolevulinic_acid	128,153	transferrin_receptor	12,32	delta-aminolevulinic acid	transferrin receptor	MESH:D000622	7037	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	The role of transferrin_receptor -LRB- CD71 -RRB- in photodynamic therapy of activated and malignant lymphocytes using the heme precursor delta-aminolevulinic_acid -LRB- ALA -RRB- .
8081841	1	delta-lactones	96,110	protein_kinase_C	135,151	delta-lactones	protein kinase C	CHEBI:18946	112476	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Differential interaction of delta-lactones and gamma-lactones with protein_kinase_C -LRB- PK-C -RRB- .
699971	0	delta1-tetrahydrocannabinol	15,42	prolactin	95,104	delta1-tetrahydrocannabinol	prolactin	MESH:D013759	19109(Tax:10090)	Chemical	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	The effects of delta1-tetrahydrocannabinol on mammary gland growth , enzyme activity and plasma prolactin levels in the mouse .
11078439	0	delta4-androstenedione	119,141	renin	164,169	delta4-androstenedione	renin	MESH:D000735	5972	Chemical	Gene	active|amod|START_ENTITY END_ENTITY|amod|active	Plasma endothelin and LH-RH , LH , FSH , prolactin , progesterone , 17alpha-hydroxyprogesterone , estrone , 17beta-estradiol , delta4-androstenedione , testosterone , active renin , angiotensin-II and ANP levels in blood and LH , estrone and 17beta-estradiol and pregnanediol levels in urine of normal cycling women .
11078571	0	delta7-sterol	48,61	DHCR7	78,83	delta7-sterol	DHCR7	null	1717	Chemical	Gene	reductase|amod|START_ENTITY gene|amod|reductase gene|appos|END_ENTITY	Homozygosity for the W151X stop mutation in the delta7-sterol reductase gene -LRB- DHCR7 -RRB- causing a lethal form of Smith-Lemli-Opitz_syndrome : retrospective molecular diagnosis .
9813289	0	delta9-THC	33,43	CB1	83,86	delta9-THC	CB1	MESH:D013759	25248(Tax:10116)	Chemical	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Effects of long-term exposure to delta9-THC on expression of cannabinoid_receptor -LRB- CB1 -RRB- mRNA in different rat brain regions .
9813289	0	delta9-THC	33,43	cannabinoid_receptor	61,81	delta9-THC	cannabinoid receptor	MESH:D013759	25248(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effects of long-term exposure to delta9-THC on expression of cannabinoid_receptor -LRB- CB1 -RRB- mRNA in different rat brain regions .
10546994	0	delta9-THC	11,21	prolactin	37,46	delta9-THC	prolactin	MESH:D013759	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Effects of delta9-THC on VIP-induced prolactin secretion in anterior pituitary cultures : evidence for the presence of functional cannabinoid CB1 receptors in pituitary cells .
14718593	0	delta9-tetrahydrocannabinol	24,51	CB1	74,77	delta9-tetrahydrocannabinol	CB1	MESH:D013759	12801(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|knockout knockout|compound|END_ENTITY	Differential effects of delta9-tetrahydrocannabinol and methanandamide in CB1 knockout and wild-type mice .
9115639	0	delta9-tetrahydrocannabinol	50,77	interleukin-2_receptor_alpha	13,41	delta9-tetrahydrocannabinol	interleukin-2 receptor alpha	MESH:D013759	3559	Chemical	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Induction of interleukin-2_receptor_alpha gene by delta9-tetrahydrocannabinol is mediated by nuclear factor kappaB and CB1 cannabinoid receptor .
21114028	0	deltamethrin	53,65	MG-132	22,28	deltamethrin	MG-132	MESH:C017180	875581(Tax:243273)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|effects effects|nmod|END_ENTITY	-LSB- Protected effects of MG-132 on apoptosis induced by deltamethrin in rat 's hippocampus -RSB- .
16673815	0	deltamethrin	37,49	Tyrosine_hydroxylase	0,20	deltamethrin	Tyrosine hydroxylase	MESH:C017180	25085(Tax:10116)	Chemical	Gene	target|nmod|START_ENTITY END_ENTITY|nmod|target	Tyrosine_hydroxylase as a target for deltamethrin in the nigrostriatal dopaminergic pathway .
21658436	0	deltamethrin	10,22	metallothionein_A	61,78	deltamethrin	metallothionein A	MESH:C017180	100136731(Tax:8022)	Chemical	Gene	exposure|compound|START_ENTITY Impact|nmod|exposure Impact|nmod|END_ENTITY	Impact of deltamethrin exposure on mRNA expression levels of metallothionein_A , B and cytochrome P450 1A in rainbow_trout muscles .
12641839	0	demecarium_bromide	51,69	acetylcholinesterase	79,99	demecarium bromide	acetylcholinesterase	MESH:C100193	489828(Tax:9615)	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	The effects of topical ocular application of 0.25 % demecarium_bromide on serum acetylcholinesterase levels in normal dogs .
17535857	0	demethoxy_curcuminoids	45,67	heme_oxygenase-1	14,30	demethoxy curcuminoids	heme oxygenase-1	null	15368(Tax:10090)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of heme_oxygenase-1 expression by demethoxy_curcuminoids through Nrf2 by a PI3-kinase/Akt-mediated pathway in mouse beta-cells .
19020778	0	demethoxydehydroaltenusin	34,59	DNA_polymerase_alpha	108,128	demethoxydehydroaltenusin	DNA polymerase alpha	null	5422	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The specific inhibitory effect of demethoxydehydroaltenusin , a derivative of dehydroaltenusin , on mammalian DNA_polymerase_alpha .
116249	0	demethylchlortetracycline	10,35	angiotensin_II	80,94	demethylchlortetracycline	angiotensin II	MESH:D003707	183	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of demethylchlortetracycline on the hydrosmotic response of toad skin to angiotensin_II .
112337	0	demethylchlortetracycline	80,105	antidiuretic_hormone	44,64	demethylchlortetracycline	antidiuretic hormone	MESH:D003707	551	Chemical	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	-LSB- Treatment of the syndrome of inappropriate antidiuretic_hormone secretion with demethylchlortetracycline -LRB- author 's transl -RRB- -RSB- .
18811684	0	deoxyArbutin	38,50	tyrosinase	13,23	deoxyArbutin	tyrosinase	MESH:C504954	7299	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|Mechanism Mechanism|nmod|END_ENTITY	Mechanism of tyrosinase inhibition by deoxyArbutin and its second-generation derivatives .
2971490	0	deoxyadenosine	92,106	adenosine_deaminase	110,129	deoxyadenosine	adenosine deaminase	MESH:D003839	100	Chemical	Gene	START_ENTITY|nmod|deficiency deficiency|amod|END_ENTITY	Rejection of bone marrow transplant and resistance of alloantigen reactive cells to in vivo deoxyadenosine in adenosine_deaminase deficiency .
6231047	0	deoxyadenosine	14,28	adenosine_deaminase	122,141	deoxyadenosine	adenosine deaminase	MESH:D003839	100	Chemical	Gene	toxicity|amod|START_ENTITY Mechanisms|nmod|toxicity Mechanisms|dep|relevance relevance|nmod|use use|nmod|inhibitors inhibitors|nmod|END_ENTITY	Mechanisms of deoxyadenosine toxicity in human lymphoid cells in vitro : relevance to the therapeutic use of inhibitors of adenosine_deaminase .
6980023	0	deoxyadenosine_nucleotides	29,55	adenosine_deaminase	69,88	deoxyadenosine nucleotides	adenosine deaminase	null	100	Chemical	Gene	START_ENTITY|nmod|deficiency deficiency|compound|END_ENTITY	Formation and degradation of deoxyadenosine_nucleotides in inherited adenosine_deaminase deficiency .
853309	0	deoxycholate	125,137	alcohol_dehydrogenase	25,46	deoxycholate	alcohol dehydrogenase	MESH:D003840	10327	Chemical	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	Assay of brain and liver alcohol_dehydrogenase by the coupled oxido-reduction of ethanol and lactaldehyde in the presence of deoxycholate .
3891746	0	deoxycholate	17,29	catalase	69,77	deoxycholate	catalase	MESH:D003840	24248(Tax:10116)	Chemical	Gene	Interaction|nmod|START_ENTITY END_ENTITY|nsubj|Interaction	Interaction with deoxycholate of rat liver peroxisomal and cytosolic catalase .
14656946	0	deoxycholic_acid	14,30	NF-kappaB	61,70	deoxycholic acid	NF-kappaB	MESH:D003840	4790	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	The bile_acid deoxycholic_acid -LRB- DCA -RRB- at neutral pH activates NF-kappaB and induces IL-8 expression in oesophageal cells in vitro .
3924707	0	deoxycholic_acid	110,126	ornithine_decarboxylase	73,96	deoxycholic acid	ornithine decarboxylase	MESH:D003840	24609(Tax:10116)	Chemical	Gene	induction|nmod|START_ENTITY END_ENTITY|acl|induction	Prostaglandin_E2 counteracts the inhibition by indomethacin of rat colon ornithine_decarboxylase induction by deoxycholic_acid .
8986139	0	deoxycoformycin	10,25	CD26	95,99	deoxycoformycin	CD26	MESH:D015649	1803	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of deoxycoformycin and Val-boroPro on the associated catalytic activities of lymphocyte CD26 and ecto-adenosine deaminase .
455289	0	deoxycoformycin	14,29	adenosine_deaminase	48,67	deoxycoformycin	adenosine deaminase	MESH:D015649	11486(Tax:10090)	Chemical	Gene	infusion|compound|START_ENTITY infusion|nmod|END_ENTITY	Effects of 2 ' - deoxycoformycin infusion on mouse adenosine_deaminase .
11893896	0	deoxycorticosterone_acetate	41,68	endothelin-1	14,26	deoxycorticosterone acetate	endothelin-1	null	1906	Chemical	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Regulation of endothelin-1 production in deoxycorticosterone_acetate - salt-treated endothelial cells .
23876819	0	deoxyelephantopin	76,93	cytochrome_P450	23,38	deoxyelephantopin	cytochrome P450	MESH:C528427	4051	Chemical	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Evaluation of in vitro cytochrome_P450 induction and inhibition activity of deoxyelephantopin , a sesquiterpene_lactone from Elephantopus scaber L. Drug metabolism involving cytochrome_P450 -LRB- CYP -RRB- enzymes is a key determinant of significant drug interactions .
12788913	1	deoxyhypusine	98,111	deoxyhypusine_synthase	115,137	deoxyhypusine	deoxyhypusine synthase	CHEBI:50038	1725	Chemical	Gene	Generation|nmod|START_ENTITY Generation|nmod|END_ENTITY	Generation of spermidine or homospermidine from deoxyhypusine by deoxyhypusine_synthase .
2137773	0	deoxymannojirimycin	11,30	thyroglobulin	81,94	deoxymannojirimycin	thyroglobulin	null	7038	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|nmod|END_ENTITY	Effects of deoxymannojirimycin and castanospermine on the polarized secretion of thyroglobulin .
15766417	0	deoxynivalenol	26,40	TAP-1	44,49	deoxynivalenol	TAP-1	MESH:C007262	6890	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	-LSB- The inhibitory effect of deoxynivalenol on TAP-1 expression in human peripheral blood mononuclear cells in vitro -RSB- .
26979077	0	deoxynivalenol	135,149	calcium-sensing_receptor	20,44	deoxynivalenol	calcium-sensing receptor	MESH:C007262	12374(Tax:10090)	Chemical	Gene	roles|nmod|START_ENTITY roles|nmod|END_ENTITY	Potential roles for calcium-sensing_receptor -LRB- CaSR -RRB- and transient_receptor_potential_ankyrin-1 -LRB- TRPA1 -RRB- in murine anorectic response to deoxynivalenol -LRB- vomitoxin -RRB- .
17707346	0	deoxynivalenol	85,99	early_growth_response_gene_1	14,42	deoxynivalenol	early growth response gene 1	MESH:C007262	1958	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Modulation of early_growth_response_gene_1 and interleukin-8 expression by ribotoxin deoxynivalenol -LRB- vomitoxin -RRB- via ERK1/2 in human epithelial intestine_407 cells .
18716445	0	deoxynivalenol	67,81	haptoglobin	7,18	deoxynivalenol	haptoglobin	MESH:C007262	24464(Tax:10116)	Chemical	Gene	intoxication|amod|START_ENTITY END_ENTITY|nmod|intoxication	Plasma haptoglobin and immunoglobulins as diagnostic indicators of deoxynivalenol intoxication .
12604170	0	deoxynivalenol	100,114	macrophage_inflammatory_protein-2	17,50	deoxynivalenol	macrophage inflammatory protein-2	MESH:C007262	20310(Tax:10090)	Chemical	Gene	Up-regulation|amod|START_ENTITY Up-regulation|nmod|END_ENTITY	Up-regulation of macrophage_inflammatory_protein-2 and complement_3A_receptor by the trichothecenes deoxynivalenol and satratoxin_G .
3346221	1	deoxynucleoside_triphosphate	98,126	terminal_deoxynucleotidyltransferase	145,181	deoxynucleoside triphosphate	terminal deoxynucleotidyltransferase	null	281120(Tax:9913)	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Affinity labeling and identification of the deoxynucleoside_triphosphate binding domain of terminal_deoxynucleotidyltransferase .
24469456	0	deoxynucleotide	101,116	drim2	31,36	deoxynucleotide	drim2	null	33350(Tax:7227)	Chemical	Gene	START_ENTITY|nsubj|characterization characterization|nmod|END_ENTITY	Functional characterization of drim2 , the Drosophila_melanogaster homolog of the yeast mitochondrial deoxynucleotide transporter .
6206825	1	deoxypyrimidine	365,380	ATP	389,392	deoxypyrimidine	GMP	null	22978	Chemical	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	The thymidine kinase-complex isolated from herpes_simplex_virus_type_1 and type 2 -LRB- HSV-1 and HSV-2 -RRB- is associated with the following enzyme activities : ATP : dThd -LRB- dCyd -RRB- deoxypyrimidine kinase , ATP : dTMP thymidylate kinase , ADP : dThd - and AMP : dThd 5 ' - phosphotransferase .
11416014	0	deoxyribonucleic_acid	114,135	GH	141,143	deoxyribonucleic acid	GH	CHEBI:16991	14599(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|compound|END_ENTITY	Identification , isolation , and cloning of growth_hormone -LRB- GH -RRB- - inducible interscapular brown adipose complementary deoxyribonucleic_acid from GH antagonist mice .
8345129	0	deoxyribonucleic_acid	20,41	Milk	0,4	deoxyribonucleic acid	Milk	CHEBI:16991	100532204	Chemical	Gene	source|nmod|START_ENTITY END_ENTITY|nmod|source	Milk as a source of deoxyribonucleic_acid and as a substrate for the polymerase chain reaction .
1972059	0	deoxyribonucleic_acid	22,43	Somatostatin	0,12	deoxyribonucleic acid	Somatostatin	CHEBI:16991	24797(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY inhibits|dobj|synthesis inhibits|nsubj|END_ENTITY	Somatostatin inhibits deoxyribonucleic_acid synthesis induced by both thyrotropin and insulin-like_growth_factor-I in FRTL5 cells .
8828833	0	deoxyribonucleic_acid	81,102	cLH-R	60,65	deoxyribonucleic acid	cLH-R	CHEBI:16991	395776(Tax:9031)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Characterization of a chicken luteinizing hormone receptor -LRB- cLH-R -RRB- complementary deoxyribonucleic_acid , and expression of cLH-R messenger ribonucleic_acid in the ovary .
3493878	0	deoxyribonucleic_acid	50,71	epidermal_growth_factor	23,46	deoxyribonucleic acid	epidermal growth factor	CHEBI:16991	13645(Tax:10090)	Chemical	Gene	synthesis|amod|START_ENTITY effects|nmod|synthesis effects|nmod|END_ENTITY	Stimulatory effects of epidermal_growth_factor on deoxyribonucleic_acid synthesis in the gastrointestinal tract of the suckling mouse .
2245830	0	deoxyribonucleic_acid	42,63	insulin-like_growth_factor_I	10,38	deoxyribonucleic acid	insulin-like growth factor I	CHEBI:16991	3479	Chemical	Gene	synthesis|amod|START_ENTITY Effect|nmod|synthesis Effect|nmod|END_ENTITY	Effect of insulin-like_growth_factor_I on deoxyribonucleic_acid synthesis in cultured human granulosa cells .
6430681	0	deoxyribonucleic_acid	23,44	polymerase_beta	45,60	deoxyribonucleic acid	polymerase beta	CHEBI:16991	29240(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Hormonal regulation of deoxyribonucleic_acid polymerase_beta activity in rat testis .
21318222	0	deoxyribonucleotide	41,60	Histone_deacetylase	0,19	deoxyribonucleotide	Histone deacetylase	CHEBI:4431	9734	Chemical	Gene	START_ENTITY|nsubj|modulates modulates|amod|END_ENTITY	Histone_deacetylase inhibition modulates deoxyribonucleotide pools and enhances the antitumor effects of the ribonucleotide reductase inhibitor 3 ' - C-methyladenosine in leukaemia cells .
6227335	0	deoxyribose	120,131	C-5	112,115	deoxyribose	C-5	MESH:D003855	727	Chemical	Gene	oxidation|nmod|START_ENTITY oxidation|nmod|END_ENTITY	Deoxyribonucleic acid damage by neocarzinostatin chromophore : strand breaks generated by selective oxidation of C-5 ' of deoxyribose .
11964177	0	deoxyspergualin	105,120	eIF5A	95,100	deoxyspergualin	eIF5A	MESH:C037258	276770(Tax:10090)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of cell growth through inactivation of eukaryotic_translation_initiation_factor_5A -LRB- eIF5A -RRB- by deoxyspergualin .
218350	0	deoxythymidine	37,51	dTK	60,63	deoxythymidine	dTK	MESH:D013936	41456(Tax:7227)	Chemical	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	Purification and characterization of deoxythymidine kinase -LRB- dTK -RRB- induced in dTK - 3T3 mouse cells by equine_herpesvirus_type_1 _ -LRB- EHV-1 -RRB- .
23043604	4	deoxyuridine	516,528	dUTPase	545,552	deoxyuridine	dUTPase	MESH:D003857	34529(Tax:7227)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	In this study , a PstI fragment of OpdiNPV genome containing the deoxyuridine triphosphatase -LRB- dUTPase -RRB- gene was successfully cloned , sequenced and analyzed .
15571278	0	deoxyuridine_triphosphate	25,50	dUTPase	72,79	deoxyuridine triphosphate	dUTPase	MESH:C027078	34529(Tax:7227)	Chemical	Gene	nucleotidohydrolase|compound|START_ENTITY nucleotidohydrolase|appos|END_ENTITY	Down-regulation of human deoxyuridine_triphosphate nucleotidohydrolase -LRB- dUTPase -RRB- using small interfering RNA -LRB- siRNA -RRB- .
3020931	0	deoxyuridine_triphosphate	74,99	dUTPase	121,128	deoxyuridine triphosphate	dUTPase	MESH:C027078	34529(Tax:7227)	Chemical	Gene	activity|amod|START_ENTITY activity|dep|END_ENTITY	Enhancement of methotrexate cytotoxicity by uracil analogues that inhibit deoxyuridine_triphosphate nucleotidohydrolase -LRB- dUTPase -RRB- activity .
8923782	0	deoxyuridine_triphosphate	9,34	dUTPase	56,63	deoxyuridine triphosphate	dUTPase	MESH:C027078	34529(Tax:7227)	Chemical	Gene	START_ENTITY|dobj|activity activity|appos|END_ENTITY	Elevated deoxyuridine_triphosphate nucleotidohydrolase -LRB- dUTPase -RRB- activity in the cobalamin-deficient megaloblastic bone marrow cells .
807570	0	deoxyuridylate	15,29	thymidylate_synthetase	35,57	deoxyuridylate	thymidylate synthetase	CHEBI:17622	7298	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of deoxyuridylate with thymidylate_synthetase .
26915220	0	deoxyverticillin_A	22,40	PFKFB3	1,7	deoxyverticillin A	PFKFB3	null	5209	Chemical	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	-LSB- PFKFB3 regulates 11 ' - deoxyverticillin_A -LRB- C42 -RRB- - induced autophagy and apoptosis in HeLa cells -RSB- .
22982864	0	dephospho-CoA	38,51	CoA_synthase	71,83	dephospho-CoA	CoA synthase	MESH:C015787	80347	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	EDC4 interacts with and regulates the dephospho-CoA kinase activity of CoA_synthase .
8557604	0	dephostatin	66,77	protein_tyrosine_phosphatase	14,42	dephostatin	protein tyrosine phosphatase	MESH:C084037	26191	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Synthesis and protein_tyrosine_phosphatase inhibitory activity of dephostatin analogs .
3083608	0	deprenyl	14,22	MAO-B	110,115	deprenyl	MAO-B	MESH:D012642	25750(Tax:10116)	Chemical	Gene	Metabolism|nmod|START_ENTITY Metabolism|dep|relationship relationship|acl|END_ENTITY	Metabolism of deprenyl , a selective monoamine_oxidase _ -LRB- MAO -RRB- _ B inhibitor in rat : relationship of metabolism to MAO-B inhibitory potency .
8075358	0	deprenyl	23,31	cytochrome_P450_2D6	106,125	deprenyl	cytochrome P450 2D6	MESH:D012642	1565	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|nmod|END_ENTITY	Atypical metabolism of deprenyl and its enantiomer , -LRB- S -RRB- - -LRB- + -RRB- - N,alpha-dimethyl-N-propynylphenethylamine , by cytochrome_P450_2D6 .
15628602	0	deprenyl	132,140	monoamine_oxidase_B	95,114	deprenyl	monoamine oxidase B	MESH:D012642	109731(Tax:10090)	Chemical	Gene	inhibition|nmod|START_ENTITY mice|acl|inhibition mice|nmod|sensitivity sensitivity|nmod|END_ENTITY	-LSB- The effect of long-term administration of isatin and himantan to mice on sensitivity of brain monoamine_oxidase_B to inhibition by deprenyl in vivo and in vitro -RSB- .
6776576	0	deprenyl	14,22	monoamine_oxidase_B	36,55	deprenyl	monoamine oxidase B	MESH:D012642	4129	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	The effect of deprenyl , a selective monoamine_oxidase_B inhibitor , on sleep and mood in man .
833580	0	deprenyl	60,68	monoamine_oxidase_B	86,105	deprenyl	monoamine oxidase B	MESH:D012642	25750(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY rats|acl|induced activity|nmod|rats Desynchronization|nmod|activity Desynchronization|dep|inhibitor inhibitor|nmod|END_ENTITY	Desynchronization of electrical activity in rats induced by deprenyl -- an inhibitor of monoamine_oxidase_B -- and relationship with selective increase of dopamine and beta-phenylethylamine .
19362837	0	depsidone	54,63	Protein_tyrosine_phosphatase_1B	0,31	depsidone	Protein tyrosine phosphatase 1B	MESH:C000875	5770	Chemical	Gene	effects|nmod|START_ENTITY effects|amod|END_ENTITY	Protein_tyrosine_phosphatase_1B inhibitory effects of depsidone and pseudodepsidone metabolites from the Antarctic_lichen Stereocaulon alpinum .
25198888	0	depsidone	86,95	acetylcholinesterase	29,49	depsidone	acetylcholinesterase	MESH:C000875	43	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	A computational insight into acetylcholinesterase inhibitory activity of a new lichen depsidone .
21340509	0	dequalinium	20,31	XIAP	37,41	dequalinium	XIAP	MESH:D003868	331	Chemical	Gene	START_ENTITY|nmod|antagonist antagonist|compound|END_ENTITY	Characterization of dequalinium as a XIAP antagonist that targets the BIR2 domain .
12584683	0	deracoxib	10,19	COX-2	27,32	deracoxib	COX-2	MESH:C471996	804479(Tax:9615)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Effect of deracoxib , a new COX-2 inhibitor , on the prevention of lameness induced by chemical synovitis in dogs .
15932955	0	deramciclane	18,30	CYP2E1	8,14	deramciclane	CYP2E1	MESH:C060555	25086(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY Role|nmod|metabolism Role|nmod|END_ENTITY	Role of CYP2E1 in deramciclane metabolism .
19019412	0	dermatan_sulfate	28,44	antithrombin	55,67	dermatan sulfate	antithrombin	MESH:D003871	462	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Characterization of a novel dermatan_sulfate with high antithrombin activity from ray skin -LRB- Raja radula -RRB- .
6633818	0	dermorphin	22,32	growth_hormone	87,101	dermorphin	growth hormone	MESH:C030058	2688	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|compound|END_ENTITY	Stimulatory effect of dermorphin , a new synthetic potent opiate-like peptide , on human growth_hormone secretion .
21854759	0	des-F-sitagliptin	16,33	DPP-4	0,5	des-F-sitagliptin	DPP-4	null	13482(Tax:10090)	Chemical	Gene	treatment|compound|START_ENTITY treatment|compound|END_ENTITY	DPP-4 inhibitor des-F-sitagliptin treatment increased insulin exocytosis from db/db mice b cells .
22493727	0	des-fluoro-sitagliptin	47,69	dipeptidyl_peptidase-IV	12,35	des-fluoro-sitagliptin	dipeptidyl peptidase-IV	null	25253(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Effect of a dipeptidyl_peptidase-IV inhibitor , des-fluoro-sitagliptin , on neointimal formation after balloon_injury in rats .
1334890	0	des-gamma-carboxy	26,43	IL-6	14,18	des-gamma-carboxy	IL-6	null	3569	Chemical	Gene	synthesis|amod|START_ENTITY effect|nmod|synthesis effect|nmod|END_ENTITY	The effect of IL-6 on the des-gamma-carboxy prothrombin synthesis in human hepatoma cells .
12400845	0	des-gamma-carboxy	15,32	prothrombin	33,44	des-gamma-carboxy	prothrombin	null	2147	Chemical	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	Measurement of des-gamma-carboxy prothrombin levels in hemodialysis patients positive for anti-hepatitis_virus_C antibody .
12397045	0	desacyl	19,26	ghrelin	27,34	desacyl	ghrelin	null	58991(Tax:10090)	Chemical	Gene	concentrations|amod|START_ENTITY concentrations|compound|END_ENTITY	Plasma ghrelin and desacyl ghrelin concentrations in renal_failure .
20201781	0	desethylamiodarone	44,62	CYP1A1	72,78	desethylamiodarone	CYP1A1	MESH:C036116	1543	Chemical	Gene	Assessment|nmod|START_ENTITY Assessment|nmod|END_ENTITY	Assessment of the inactivation potential of desethylamiodarone on human CYP1A1 .
19939449	0	desferrioxamine	96,111	CCL-20	39,45	desferrioxamine	CCL-20	MESH:D003676	6364	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Macrophage-inflammatory_protein-3alpha / CCL-20 is transcriptionally induced by the iron chelator desferrioxamine in human mononuclear phagocytes through nuclear_factor _ -LRB- NF -RRB- - kappaB .
3196300	0	desferrioxamine	33,48	transferrin	13,24	desferrioxamine	transferrin	MESH:D003676	7018	Chemical	Gene	Chelation|nmod|START_ENTITY Chelation|nmod|iron iron|compound|END_ENTITY	Chelation of transferrin iron by desferrioxamine in K562 cells .
3790074	0	desferrioxamine	14,29	transferrin	33,44	desferrioxamine	transferrin	MESH:D003676	7018	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|receptors receptors|compound|END_ENTITY	The effect of desferrioxamine on transferrin receptors , the cell cycle and growth rates of human leukaemic cells .
6142046	0	desferrioxamine	61,76	transferrin	37,48	desferrioxamine	transferrin	MESH:D003676	7018	Chemical	Gene	receptor|nmod|START_ENTITY receptor|compound|END_ENTITY	Biosynthetic regulation of the human transferrin receptor by desferrioxamine in K562 cells .
728460	0	desferrioxamine	130,145	transferrin	32,43	desferrioxamine	transferrin	MESH:D003676	7018	Chemical	Gene	Chang|nmod|START_ENTITY Chang|dobj|cells cells|nmod|complexes complexes|compound|END_ENTITY	Iron uptake by Chang cells from transferrin , nitriloacetate and citrate complexes : the effects of iron-loading and chelation with desferrioxamine .
974036	0	desferrioxamine	54,69	transferrin	39,50	desferrioxamine	transferrin	MESH:D003676	7018	Chemical	Gene	mediated|advcl|START_ENTITY mediated|nmod|END_ENTITY	Chelate mediated transfer of iron from transferrin to desferrioxamine .
11323344	5	desflurane	588,598	NMDA	602,606	desflurane	NR2B	MESH:C053562	100126610(Tax:8355)	Chemical	Gene	START_ENTITY|nmod|signaling signaling|compound|END_ENTITY	We determined the effects of isoflurane , sevoflurane , and desflurane on NMDA receptor signaling , alone and in combination with S -LRB- + -RRB- - ketamine -LRB- 4.1 microM on NR1/NR2A , 3.0 microM on NR2/NR2B -RRB- and/or Mg2 + -LRB- 416 microM on NR1/NR2A , 629 microM on NR1/NR2B -RRB- .
870511	0	desimipramin	43,55	growth_hormone	15,29	desimipramin	growth hormone	null	2688	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Stimulation Stimulation|nmod|END_ENTITY	Stimulation of growth_hormone secretion by desimipramin and chlorimipramin in man .
4001280	0	desimipramine	95,108	growth_hormone	15,29	desimipramine	growth hormone	null	2688	Chemical	Gene	stimulation|nmod|START_ENTITY stimulation|compound|END_ENTITY	Dose-dependent growth_hormone , prolactin and cortisol stimulation after i.v. administration of desimipramine in human subjects .
17356567	0	desipramine	19,30	ABCB1	44,49	desipramine	ABCB1	MESH:D003891	18669(Tax:10090)	Chemical	Gene	requires|nsubj|START_ENTITY requires|dobj|END_ENTITY	The antidepressant desipramine requires the ABCB1 -LRB- Mdr1 -RRB- - type p-glycoprotein to upregulate the glucocorticoid receptor in mice .
24742525	0	desipramine	29,40	CA1	106,109	desipramine	CA1	MESH:D003891	310218(Tax:10116)	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|ccomp|-RSB- -RSB-|nmod|cells cells|nummod|END_ENTITY	The tricyclic antidepressant desipramine inhibited the neurotoxic , kainate-induced -LSB- Ca -LRB- 2 + -RRB- -RSB- i increases in CA1 pyramidal cells in acute hippocampal slices .
8737449	0	desipramine	10,21	CA1	61,64	desipramine	CA1	MESH:D003891	310218(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	Effect of desipramine on spontaneous activity of hippocampal CA1 neuron after transient_cerebral_ischemia in rats .
20428789	0	desipramine	11,22	Ca3/7	58,63	desipramine	Ca3/7	MESH:D003891	12350;12354	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|cells cells|amod|END_ENTITY	Effects of desipramine on the cell cycle and apoptosis in Ca3/7 mouse skin squamous_carcinoma cells .
12644358	0	desipramine	43,54	GAP-43	14,20	desipramine	GAP-43	MESH:D003891	29423(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY expression|nmod|treatment expression|compound|END_ENTITY	Regulation of GAP-43 expression by chronic desipramine treatment in rat cultured hippocampal cells .
4092710	0	desipramine	29,40	Growth_hormone	0,14	desipramine	Growth hormone	MESH:D003891	2688	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|END_ENTITY	Growth_hormone release after desipramine in depressive_illness .
8464952	0	desipramine	10,21	corticotropin-releasing_factor	63,93	desipramine	corticotropin-releasing factor	MESH:D003891	1392	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|concentrations concentrations|nmod|END_ENTITY	Effect of desipramine on cerebrospinal fluid concentrations of corticotropin-releasing_factor in human subjects .
1849767	0	desipramine	52,63	growth_hormone	13,27	desipramine	growth hormone	MESH:D003891	81668(Tax:10116)	Chemical	Gene	elicited|nmod|START_ENTITY elicited|nsubj|Secretion Secretion|nmod|END_ENTITY	Secretion of growth_hormone elicited by intravenous desipramine in the conscious , unrestrained rat .
2095944	0	desipramine	31,42	growth_hormone	13,27	desipramine	growth hormone	MESH:D003891	2688	Chemical	Gene	Responses|acl|START_ENTITY Responses|nmod|END_ENTITY	Responses of growth_hormone to desipramine in endogenous and non-endogenous_depression .
2101962	0	desipramine	56,67	growth_hormone	76,90	desipramine	growth hormone	MESH:D003891	2688	Chemical	Gene	Influence|nmod|START_ENTITY Influence|acl|induced induced|dobj|stimulation stimulation|amod|END_ENTITY	Influence of clenbuterol , a_beta-adrenergic agonist , on desipramine induced growth_hormone , prolactin and cortisol stimulation .
582390	0	desipramine	52,63	growth_hormone	90,104	desipramine	growth hormone	MESH:D003891	2688	Chemical	Gene	START_ENTITY|nmod|secretion secretion|nmod|END_ENTITY	-LSB- Influence of single and repeated administration of desipramine -LRB- DMI -RRB- on the secretion of growth_hormone -LRB- GH -RRB- -LRB- author 's transl -RRB- -RSB- .
12091475	0	desipramine	11,22	norepinephrine_transporter	36,62	desipramine	norepinephrine transporter	MESH:D003891	6530	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|expression expression|compound|END_ENTITY	Effects of desipramine treatment on norepinephrine_transporter gene expression in the cultured SK-N-BE -LRB- 2 -RRB- M17 cells and rat brain tissue .
16393266	0	desloratadine	10,23	granulocyte-macrophage_colony-stimulating_factor	43,91	desloratadine	granulocyte-macrophage colony-stimulating factor	MESH:C121345	1437	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of desloratadine on epithelial cell granulocyte-macrophage_colony-stimulating_factor secretion and eosinophil survival .
10800633	0	desloratadine	28,41	histamine_H1_receptor	71,92	desloratadine	histamine H1 receptor	MESH:C121345	100135539(Tax:10141)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Preclinical pharmacology of desloratadine , a selective and nonsedating histamine_H1_receptor antagonist .
9608582	0	desmethylclozapine	11,29	Fos	33,36	desmethylclozapine	Fos	CHEBI:64050	2353	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effects of desmethylclozapine on Fos protein expression in the forebrain : in vivo biological activity of the clozapine metabolite .
9634021	0	desmopressin	77,89	antidiuretic_hormone	14,34	desmopressin	antidiuretic hormone	MESH:D003894	551	Chemical	Gene	Evaluation|nmod|START_ENTITY Evaluation|nmod|END_ENTITY	Evaluation of antidiuretic_hormone before and after long-term treatment with desmopressin in a group of enuretic children .
3437027	0	desmosine	57,66	elastin	143,150	desmosine	elastin	MESH:D003895	25043(Tax:10116)	Chemical	Gene	determination|nmod|START_ENTITY determination|nmod|END_ENTITY	High-performance liquid chromatographic determination of desmosine and isodesmosine in tissues and its application to studies of alteration of elastin induced by atherosclerosis .
2869571	0	desmosines	40,50	Lysyl_oxidase	0,13	desmosines	Lysyl oxidase	null	4015	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Lysyl_oxidase activity and synthesis of desmosines in cultured human aortic cells and skin fibroblasts : comparison of cell lines from control subjects and patients with the Marfan_syndrome or other annulo-aortic ectasia .
2224103	0	desoxycorticosterone	12,32	5-nucleotidase	36,50	desoxycorticosterone	5-nucleotidase	MESH:D003900	56780(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	-LSB- Effects of desoxycorticosterone on 5-nucleotidase and adenosine_deaminase activity in the hypothalamus and hippocampus of the rat brain -RSB- .
25274440	0	desoxycorticosterone	110,130	Renin	14,19	desoxycorticosterone	Renin	MESH:D003900	403838(Tax:9615)	Chemical	Gene	Use|dep|START_ENTITY Use|nmod|activity activity|compound|END_ENTITY	Use of plasma Renin activity to monitor mineralocorticoid treatment in dogs with primary hypoadrenocorticism : desoxycorticosterone versus fludrocortisone .
6998621	0	desoxycorticosterone	84,104	Renin	0,5	desoxycorticosterone	Renin	MESH:D003900	24715(Tax:10116)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|amod|END_ENTITY	Renin secretion and renal vascular resistance following prolonged administration of desoxycorticosterone -LRB- DOC -RRB- in rats drinking normal saline .
5762532	0	desoxycorticosterone	74,94	renin	11,16	desoxycorticosterone	renin	MESH:D003900	24715(Tax:10116)	Chemical	Gene	hypertension|amod|START_ENTITY renin|nmod|hypertension relationship|nmod|renin Release|dep|relationship Release|nmod|END_ENTITY	Release of renin by rat kidney slices ; relationship to plasma renin after desoxycorticosterone and renal hypertension .
5762532	0	desoxycorticosterone	74,94	renin	62,67	desoxycorticosterone	renin	MESH:D003900	24715(Tax:10116)	Chemical	Gene	hypertension|amod|START_ENTITY END_ENTITY|nmod|hypertension	Release of renin by rat kidney slices ; relationship to plasma renin after desoxycorticosterone and renal hypertension .
23586711	0	desoxyritonavir	21,36	cytochrome_P450_3A4	67,86	desoxyritonavir	cytochrome P450 3A4	null	1576	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Pyridine-substituted desoxyritonavir is a more potent inhibitor of cytochrome_P450_3A4 than ritonavir .
2763270	0	desulfato_hirudin54-65	54,76	antithrombin	80,92	desulfato hirudin54-65	antithrombin	null	462	Chemical	Gene	agents|amod|START_ENTITY agents|amod|END_ENTITY	C-terminal peptide alcohol , acid and amide analogs of desulfato_hirudin54-65 as antithrombin agents .
6197725	0	deuterium_oxide	10,25	gastrin	29,36	deuterium oxide	gastrin	MESH:D017666	25320(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	Effect of deuterium_oxide on gastrin release from rat antral mucosal fragments .
12007923	0	devazepide	84,94	CCK	57,60	devazepide	CCK	MESH:D020109	25298(Tax:10116)	Chemical	Gene	Effects|dep|START_ENTITY Effects|nmod|administration administration|nmod|END_ENTITY	Effects of intracerebroventricular administration of the CCK -LRB- 1 -RRB- receptor antagonist devazepide on food intake in rats .
1448490	0	devazepide	31,41	CCK	74,77	devazepide	CCK	MESH:D020109	25298(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY blocks|nsubj|antagonist blocks|dobj|action action|nmod|END_ENTITY	The CCK-A_receptor antagonist , devazepide , blocks the anorectic action of CCK but not peripheral serotonin in rats .
8281982	0	devazepide	52,62	CCK	77,80	devazepide	CCK	MESH:D020109	25298(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|mRNA mRNA|compound|END_ENTITY	Effects of diet and the cholecystokinin antagonist ; devazepide -LRB- L364 ,718 -RRB- on CCK mRNA , and tissue and plasma CCK concentrations .
1448490	0	devazepide	31,41	CCK-A_receptor	4,18	devazepide	CCK-A receptor	MESH:D020109	24889(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	The CCK-A_receptor antagonist , devazepide , blocks the anorectic action of CCK but not peripheral serotonin in rats .
8742464	0	devazepide	30,40	CCKA	14,18	devazepide	CCKA	MESH:D020109	886	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|antagonist antagonist|compound|END_ENTITY	Effect of the CCKA antagonist devazepide on eating stimulated by raphe injection of 8-OH-DPAT .
8620940	0	devazepide	57,67	cholecystokinin-A_receptor	18,44	devazepide	cholecystokinin-A receptor	MESH:D020109	422801(Tax:9031)	Chemical	Gene	action|amod|START_ENTITY action|nmod|END_ENTITY	The action of the cholecystokinin-A_receptor antagonist , devazepide , on the digestive system of the chicken .
2059213	0	dexamethasone	109,122	15-PGDH	97,104	dexamethasone	15-PGDH	MESH:D003907	3248	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of synthesis and activity of NAD -LRB- + -RRB- - dependent 15-hydroxy-prostaglandin_dehydrogenase -LRB- 15-PGDH -RRB- by dexamethasone and phorbol_ester in human_erythroleukemia -LRB- HEL -RRB- cells .
7916919	0	dexamethasone	61,74	5-HT1A_receptor	26,41	dexamethasone	5-HT1A receptor	MESH:D003907	3350	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of hippocampal 5-HT1A_receptor gene expression by dexamethasone .
15285965	0	dexamethasone	21,34	ACTH	4,8	dexamethasone	ACTH	MESH:D003907	5443	Chemical	Gene	START_ENTITY|nsubj|response response|compound|END_ENTITY	The ACTH response to dexamethasone in PTSD .
16891596	0	dexamethasone	21,34	ACTH	4,8	dexamethasone	ACTH	MESH:D003907	5443	Chemical	Gene	START_ENTITY|nsubj|response response|compound|END_ENTITY	The ACTH response to dexamethasone in Persian Gulf War veterans .
191052	0	dexamethasone	77,90	ACTH	0,4	dexamethasone	ACTH	MESH:D003907	5443	Chemical	Gene	therapy|compound|START_ENTITY END_ENTITY|nmod|therapy	ACTH levels in maternal , fetal and neonatal plasma after short-term prenatal dexamethasone therapy .
2546508	0	dexamethasone	5,18	ACTH	32,36	dexamethasone	ACTH	MESH:D003907	5443	Chemical	Gene	suppress|nsubj|START_ENTITY suppress|dobj|response response|compound|END_ENTITY	Does dexamethasone suppress the ACTH response in preterm babies ?
2829509	0	dexamethasone	41,54	ACTH	15,19	dexamethasone	ACTH	MESH:D003907	5443	Chemical	Gene	test|amod|START_ENTITY Measurement|nmod|test Measurement|nmod|END_ENTITY	Measurement of ACTH and prolactin in the dexamethasone suppression test .
3000118	0	dexamethasone	63,76	ACTH	94,98	dexamethasone	ACTH	MESH:D003907	5443	Chemical	Gene	secretion|amod|START_ENTITY secretion|compound|END_ENTITY	Cyclic Cushing 's _ syndrome combined with cortisol suppressible , dexamethasone non-suppressible ACTH secretion : a new variant of Cushing 's _ syndrome .
6280027	0	dexamethasone	13,26	ACTH	1,5	dexamethasone	ACTH	MESH:D003907	5443	Chemical	Gene	test|amod|START_ENTITY END_ENTITY|nmod|test	-LSB- ACTH in the dexamethasone suppression test -RSB- .
6281630	0	dexamethasone	22,35	ACTH	1,5	dexamethasone	ACTH	MESH:D003907	5443	Chemical	Gene	test|amod|START_ENTITY response|nmod|test response|compound|END_ENTITY	-LSB- ACTH response in the dexamethasone suppression test -RSB- .
6310664	0	dexamethasone	70,83	ACTH	7,11	dexamethasone	ACTH	MESH:D003907	5443	Chemical	Gene	test|amod|START_ENTITY relationship|nmod|test levels|dep|relationship levels|compound|END_ENTITY	Plasma ACTH levels in primary depression : relationship to the 24-hour dexamethasone suppression test .
6320245	0	dexamethasone	80,93	ACTH	7,11	dexamethasone	ACTH	MESH:D003907	5443	Chemical	Gene	test|amod|START_ENTITY relationship|nmod|test levels|dep|relationship levels|compound|END_ENTITY	Plasma ACTH levels in depression before and after recovery : relationship to the dexamethasone suppression test .
8402922	0	dexamethasone	119,132	ACTH	25,29	dexamethasone	ACTH	MESH:D003907	5443	Chemical	Gene	presence|nmod|START_ENTITY altered|nmod|presence altered|nsubjpass|activity activity|nmod|END_ENTITY	The biologic activity of ACTH and related peptides on peripheral blood mononuclear cells is altered by the presence of dexamethasone .
8550955	0	dexamethasone	59,72	ACTH	113,117	dexamethasone	ACTH	MESH:D003907	5443	Chemical	Gene	suppression|nmod|START_ENTITY androstenedione|nmod|suppression escape|nmod|androstenedione escape|dep|relationships relationships|nmod|END_ENTITY	An augmented escape of androstenedione from suppression by dexamethasone in melancholia : relationships to intact ACTH and cortisol nonsuppression .
9475079	0	dexamethasone	10,23	ATPase	65,71	dexamethasone	ATPase	MESH:D003907	1769	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of dexamethasone and corticosterone on activity levels of ATPase , phosphomonoesterases and phosphodiesterase in liver , muscle and testis of post-hatched White Leghorn chicks .
18363889	0	dexamethasone	94,107	Adiponectin	0,11	dexamethasone	Adiponectin	MESH:D003907	9370	Chemical	Gene	expression|nmod|START_ENTITY END_ENTITY|appos|expression	Adiponectin , skeletal muscle adiponectin receptor expression and insulin resistance following dexamethasone .
15523051	0	dexamethasone	216,229	Akt	164,167	dexamethasone	Akt	MESH:D003907	24185(Tax:10116)	Chemical	Gene	actions|nmod|START_ENTITY END_ENTITY|nmod|actions	Receptor-independent activation of GABAergic neurotransmission and receptor-dependent nontranscriptional activation of phosphatidylinositol 3-kinase/protein kinase Akt pathway in short-term cardiovascular actions of dexamethasone at the nucleus tractus solitarii of the rat .
12887795	0	dexamethasone	94,107	Annexin_I	34,43	dexamethasone	Annexin I	MESH:D003907	16952(Tax:10090)	Chemical	Gene	-RSB-|amod|START_ENTITY induced|nmod|-RSB- induced|nsubj|Study Study|nmod|level level|nmod|END_ENTITY	-LSB- Study on the expression level of Annexin_I , cPLA -LRB- 2 -RRB- and PCNA in cleft-palate mice induced by dexamethasone -RSB- .
18421047	0	dexamethasone	27,40	Asparaginase	0,12	dexamethasone	Asparaginase	MESH:D003907	374569	Chemical	Gene	pharmacokinetics|amod|START_ENTITY influence|dobj|pharmacokinetics influence|nsubj|END_ENTITY	Asparaginase may influence dexamethasone pharmacokinetics in acute_lymphoblastic_leukemia .
19499314	0	dexamethasone	10,23	BAFF	33,37	dexamethasone	BAFF	MESH:D003907	10673	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	High-dose dexamethasone inhibits BAFF expression in patients with immune_thrombocytopenia .
17163378	0	dexamethasone	73,86	BDNF	39,43	dexamethasone	BDNF	MESH:D003907	627	Chemical	Gene	induced|nmod|START_ENTITY induced|nmod|END_ENTITY	-LSB- In vitro neurite outgrowth induced by BDNF and GDNF in combination with dexamethasone on cultured spiral_ganglion cells -RSB- .
9868287	0	dexamethasone	50,63	Basic_fibroblast_growth_factor	0,30	dexamethasone	Basic fibroblast growth factor	MESH:D003907	54250(Tax:10116)	Chemical	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	Basic_fibroblast_growth_factor in the presence of dexamethasone stimulates colony formation , expansion , and osteoblastic differentiation by rat bone marrow stromal cells .
23317773	0	dexamethasone	94,107	Bone_morphogenetic_protein_6	0,28	dexamethasone	Bone morphogenetic protein 6	MESH:D003907	654	Chemical	Gene	stimulates|nmod|START_ENTITY stimulates|nsubj|END_ENTITY	Bone_morphogenetic_protein_6 stimulates mineralization in human dental follicle cells without dexamethasone .
2451400	0	dexamethasone	52,65	C-reactive_protein	18,36	dexamethasone	C-reactive protein	MESH:D003907	25419(Tax:10116)	Chemical	Gene	level|nmod|START_ENTITY level|amod|END_ENTITY	Modulation of rat C-reactive_protein serum level by dexamethasone and adrenaline -- comparison with the response of alpha 2-acute phase globulin .
25519046	0	dexamethasone	68,81	CD200	0,5	dexamethasone	CD200	MESH:D003907	24560(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY END_ENTITY|dep|expression	CD200 in growing rat lungs : developmental expression and control by dexamethasone .
22349593	0	dexamethasone	20,33	CD25	44,48	dexamethasone	CD25	MESH:D003907	281861(Tax:9913)	Chemical	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	In vitro effects of dexamethasone on bovine CD25 + CD4 + and CD25-CD4 + cells .
23286953	0	dexamethasone	11,24	CD25	49,53	dexamethasone	CD25	MESH:D003907	281861(Tax:9913)	Chemical	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Effects of dexamethasone and meloxicam on bovine CD25 + CD8 + and CD25 - CD8 + T cells -- in vitro study .
22349593	0	dexamethasone	20,33	CD4	49,52	dexamethasone	CD4	MESH:D003907	407098(Tax:9913)	Chemical	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	In vitro effects of dexamethasone on bovine CD25 + CD4 + and CD25-CD4 + cells .
10959555	0	dexamethasone	30,43	CD58	21,25	dexamethasone	CD58	MESH:D003907	965	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of LFA-3 -LRB- CD58 -RRB- by dexamethasone and retinoic_acids in vitro .
11274652	0	dexamethasone	78,91	CRH	93,96	dexamethasone	CRH	MESH:D003907	1392	Chemical	Gene	predict|nmod|START_ENTITY predict|parataxis|test test|nsubj|END_ENTITY	High and low neuroticism predict different cortisol responses to the combined dexamethasone -- CRH test .
7708821	1	dexamethasone	450,463	CRH	387,390	dexamethasone	CRH	MESH:D003907	1392	Chemical	Gene	test|amod|START_ENTITY studied|nmod|test studied|nsubjpass|responses responses|appos|END_ENTITY	The responses of plasma adrenocorticotrophic hormone -LRB- corticotrophin , ACTH -RRB- , cortisol and 13,14-dihydro-15-keto-prostaglandin _ E2 -LRB- PGE2-M -RRB- , a stable metabolite of prostaglandin_E2 -LRB- PGE2 -RRB- to i.v. injection of corticotrophin-releasing_hormone -LRB- CRH -RRB- were studied in eight healthy subjects before and after a dexamethasone suppression test .
9373879	0	dexamethasone	14,27	CRH	31,34	dexamethasone	CRH	MESH:D003907	1392	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of dexamethasone on CRH and prostanoid production from human term placenta .
20113596	0	dexamethasone	12,25	CTLA-4	29,35	dexamethasone	CTLA-4	MESH:D003907	1493	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	-LSB- Effects of dexamethasone on CTLA-4 expression and apoptosis in lymphocytes obtained from children with mesangial proliferative nephritis -RSB- .
12710709	0	dexamethasone	23,36	CYP3A1	13,19	dexamethasone	CYP3A1	MESH:D003907	25642(Tax:10116)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of CYP3A1 by dexamethasone and pregnenolone-16alpha-carbonitrile in pregnant rat and fetal livers and placenta .
11737189	0	dexamethasone	15,28	CYP3A4	32,38	dexamethasone	CYP3A4	MESH:D003907	1576	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|compound|END_ENTITY	Dual effect of dexamethasone on CYP3A4 gene expression in human hepatocytes .
9337077	0	dexamethasone	23,36	CYP3A4	89,95	dexamethasone	CYP3A4	MESH:D003907	1576	Chemical	Gene	metabolism|nmod|START_ENTITY involvement|nmod|metabolism involvement|nmod|END_ENTITY	In vitro metabolism of dexamethasone -LRB- DEX -RRB- in human liver and kidney : the involvement of CYP3A4 and CYP17 -LRB- 17,20 LYASE -RRB- and molecular modelling studies .
8542313	0	dexamethasone	113,126	Corticotropin-releasing_factor	0,30	dexamethasone	Corticotropin-releasing factor	MESH:D003907	12918(Tax:10090)	Chemical	Gene	reversal|nmod|START_ENTITY upregulates|parataxis|reversal upregulates|nsubj|treatment treatment|compound|END_ENTITY	Corticotropin-releasing_factor treatment upregulates interleukin-1 receptors in the mouse pituitary : reversal by dexamethasone .
12503700	0	dexamethasone	39,52	E-cadherin	14,24	dexamethasone	E-cadherin	MESH:D003907	999	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of E-cadherin expression by dexamethasone and tumour necrosis factor-alpha in nasal epithelium .
2072891	0	dexamethasone	10,23	EGF-receptor	73,85	dexamethasone	EGF-receptor	MESH:D003907	1956	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|gene gene|amod|END_ENTITY	Effect of dexamethasone and cycloheximide on the expression of amplified EGF-receptor gene in human A431 carcinoma cell line .
1417981	0	dexamethasone	54,67	EGR-1	14,19	dexamethasone	EGR-1	MESH:D003907	1958	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Inhibition of EGR-1 and NF-kappa_B gene expression by dexamethasone during phorbol_ester-induced human monocytic differentiation .
9444616	0	dexamethasone	135,148	Endothelin-1	0,12	dexamethasone	Endothelin-1	MESH:D003907	24323(Tax:10116)	Chemical	Gene	stimulates|nmod|START_ENTITY stimulates|nsubj|END_ENTITY	Endothelin-1 stimulates the biosynthesis of tumour necrosis factor in macrophages : ET-receptors , signal transduction and inhibition by dexamethasone .
1671785	0	dexamethasone	11,24	GH	44,46	dexamethasone	GH	MESH:D003907	2688	Chemical	Gene	START_ENTITY|nmod|growth_hormone growth_hormone|appos|END_ENTITY	Effects of dexamethasone on growth_hormone -LRB- GH -RRB- - releasing hormone , arginine - and dopaminergic stimulated GH secretion , and total plasma insulin-like growth factor-I concentrations in normal male volunteers .
3917458	0	dexamethasone	10,23	GH	43,45	dexamethasone	GH	MESH:D003907	2688	Chemical	Gene	START_ENTITY|nmod|growth_hormone growth_hormone|appos|END_ENTITY	Effect of dexamethasone on growth_hormone -LRB- GH -RRB- response to growth_hormone_releasing_hormone in acromegaly .
8897851	0	dexamethasone	19,32	GLUT-4	67,73	dexamethasone	GLUT-4	MESH:D003907	25139(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	In vivo effects of dexamethasone and sucrose on glucose_transport -LRB- GLUT-4 -RRB- protein tissue distribution .
9351511	0	dexamethasone	23,36	GTP_cyclohydrolase_I	98,118	dexamethasone	GTP cyclohydrolase I	MESH:D003907	29244(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|nmod|END_ENTITY	Differential effect of dexamethasone on interleukin_1beta - and cyclic_AMP-triggered expression of GTP_cyclohydrolase_I in rat renal mesangial cells .
1400864	0	dexamethasone	97,110	Glucocorticoid_receptor	0,23	dexamethasone	Glucocorticoid receptor	MESH:D003907	2908	Chemical	Gene	resistance|nmod|START_ENTITY patients|nmod|resistance fibroblasts|nmod|patients abnormalities|nmod|fibroblasts abnormalities|amod|END_ENTITY	Glucocorticoid_receptor abnormalities in fibroblasts from patients with idiopathic resistance to dexamethasone diagnosed when evaluated for adrenocortical_disorders .
21455635	0	dexamethasone	67,80	Glucocorticoid_receptor	0,23	dexamethasone	Glucocorticoid receptor	MESH:D003907	2908	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Glucocorticoid_receptor expression and antiproliferative effect of dexamethasone on human melanoma cells .
3018491	0	dexamethasone	77,90	Glucocorticoid_receptor	0,23	dexamethasone	Glucocorticoid receptor	MESH:D003907	2908	Chemical	Gene	promoter|nmod|START_ENTITY binding|nmod|promoter END_ENTITY|dobj|binding	Glucocorticoid_receptor binding and activation of a heterologous promoter by dexamethasone by the first intron of the human growth_hormone gene .
22626647	0	dexamethasone	9,22	GnRH	47,51	dexamethasone	GnRH	MESH:D003907	14714(Tax:10090)	Chemical	Gene	down-regulates|amod|START_ENTITY END_ENTITY|nsubj|down-regulates	Neonatal dexamethasone exposure down-regulates GnRH expression through the GnIH pathway in female mice .
8852865	0	dexamethasone	66,79	Growth_hormone	0,14	dexamethasone	Growth hormone	MESH:D003907	2688	Chemical	Gene	response|acl|START_ENTITY response|amod|END_ENTITY	Growth_hormone response to clonidine and the cortisol response to dexamethasone in depressive patients .
887192	0	dexamethasone	155,168	Growth_hormone	1,15	dexamethasone	Growth hormone	MESH:D003907	2688	Chemical	Gene	-RSB-|amod|START_ENTITY dynamical|nmod|-RSB- dynamical|nsubj|END_ENTITY	-LSB- Growth_hormone , LH and FSH under function dynamical conditions in serum and basic corticol and testosterone serum levels in brain-injured patients during dexamethasone treatment -RSB- .
9388821	0	dexamethasone	58,71	Growth_hormone	0,14	dexamethasone	Growth hormone	MESH:D003907	2688	Chemical	Gene	effects|nmod|START_ENTITY prevent|dobj|effects prevent|nsubj|END_ENTITY	Growth_hormone does not prevent catabolic side effects of dexamethasone in extremely low birth weight preterm infants with bronchopulmonary_dysplasia -- a pilot study .
22563925	0	dexamethasone	38,51	HLA-G	26,31	dexamethasone	HLA-G	MESH:D003907	3135	Chemical	Gene	START_ENTITY|nmod|up-regulation up-regulation|nmod|END_ENTITY	In vitro up-regulation of HLA-G using dexamethasone and hydrocortisone in first-trimester trophoblast cells of women experiencing recurrent miscarriage .
17173546	0	dexamethasone	99,112	Hsp27	168,173	dexamethasone	Hsp27	MESH:D003907	3315	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	BIRB_796 enhances cytotoxicity triggered by bortezomib , heat_shock_protein _ -LRB- Hsp -RRB- _ 90 inhibitor , and dexamethasone via inhibition of p38_mitogen-activated_protein_kinase / Hsp27 pathway in multiple_myeloma cell lines and inhibits paracrine tumour growth .
10438953	0	dexamethasone	162,175	ICAM-1	17,23	dexamethasone	ICAM-1	MESH:D003907	3383	Chemical	Gene	sensitive|xcomp|START_ENTITY pathway|acl:relcl|sensitive involves|dobj|pathway involves|nsubj|Up-regulation Up-regulation|nmod|cells cells|amod|END_ENTITY	Up-regulation of ICAM-1 by cytokines in human tracheal smooth muscle cells involves an NF-kappa_B-dependent signaling pathway that is only partially sensitive to dexamethasone .
9070869	0	dexamethasone	32,45	ICAM-1	54,60	dexamethasone	ICAM-1	MESH:D003907	25464(Tax:10116)	Chemical	Gene	rats|nmod|START_ENTITY treatment|nmod|rats reduces|nsubj|treatment reduces|dobj|levels levels|compound|END_ENTITY	Subacute treatment of rats with dexamethasone reduces ICAM-1 levels on circulating monocytes .
15985639	0	dexamethasone	121,134	IFN-gamma	100,109	dexamethasone	IFN-gamma	MESH:D003907	3458	Chemical	Gene	effects|nmod|START_ENTITY effects|amod|END_ENTITY	Influence of IFN-gamma on gene expression in normal human bronchial epithelial cells : modulation of IFN-gamma effects by dexamethasone .
15985639	0	dexamethasone	121,134	IFN-gamma	13,22	dexamethasone	IFN-gamma	MESH:D003907	3458	Chemical	Gene	effects|nmod|START_ENTITY modulation|nmod|effects Influence|dep|modulation Influence|nmod|END_ENTITY	Influence of IFN-gamma on gene expression in normal human bronchial epithelial cells : modulation of IFN-gamma effects by dexamethasone .
9730250	0	dexamethasone	118,131	IFN-gamma	24,33	dexamethasone	IFN-gamma	MESH:D003907	15978(Tax:10090)	Chemical	Gene	exposed|xcomp|START_ENTITY exposed|nsubj|Suppression Suppression|nmod|production production|amod|END_ENTITY	Suppression of in vitro IFN-gamma production by spleen cells of Plasmodium_chabaudi-infected C57BL/10 mice exposed to dexamethasone at a low dose .
11641548	0	dexamethasone	10,23	IL-10	27,32	dexamethasone	IL-10	MESH:D003907	3586	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|production production|amod|END_ENTITY	Effect of dexamethasone on IL-10 and IL-12p40 production in newborns and adults .
20731121	0	dexamethasone	112,125	IL-1_beta	31,40	dexamethasone	IL-1 beta	MESH:D003907	3553	Chemical	Gene	-RSB-|amod|START_ENTITY Influence|nmod|-RSB- Influence|nmod|production production|amod|END_ENTITY	-LSB- Influence of polyoxidonium on IL-1_beta , TNF-alpha and IL-6 production by mononuclears and monocytes under the dexamethasone effect -RSB- .
8574830	0	dexamethasone	33,46	IL-1_beta	149,158	dexamethasone	IL-1 beta	MESH:D003907	3553	Chemical	Gene	START_ENTITY|nmod|production production|nmod|tumor_necrosis_factor_alpha tumor_necrosis_factor_alpha|appos|END_ENTITY	Effect of xanthine derivates and dexamethasone on Streptococcus_pneumoniae-stimulated production of tumor_necrosis_factor_alpha , interleukin-1_beta -LRB- IL-1_beta -RRB- , and IL-10 by human leukocytes .
9652398	0	dexamethasone	10,23	IL-1beta	46,54	dexamethasone	IL-1beta	MESH:D003907	3553	Chemical	Gene	START_ENTITY|nmod|- -|appos|END_ENTITY	Effect of dexamethasone on interleukin-1beta - -LRB- IL-1beta -RRB- - induced nuclear_factor-kappaB -LRB- NF-kappaB -RRB- and kappaB-dependent transcription in epithelial cells .
8976687	0	dexamethasone	10,23	IL-2	27,31	dexamethasone	IL-2	MESH:D003907	3558	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|production production|amod|END_ENTITY	Effect of dexamethasone on IL-2 and IL-3 production by mononuclear cells in neonates and adults .
23746235	0	dexamethasone	12,25	IL-21_and_its_receptor	44,66	dexamethasone	IL-21 and its receptor	MESH:D003907	60504;60505	Chemical	Gene	START_ENTITY|nmod|expressions expressions|nmod|END_ENTITY	-LSB- Effects of dexamethasone on expressions of IL-21_and_its_receptor in lungs of experimental asthma mice -RSB- .
12239628	0	dexamethasone	101,114	IL-6	4,8	dexamethasone	IL-6	MESH:D003907	3569	Chemical	Gene	induced|nmod|START_ENTITY effects|dep|induced enhances|dobj|effects enhances|nsubj|Sant7 Sant7|compound|END_ENTITY	The IL-6 receptor super-antagonist Sant7 enhances antiproliferative and apoptotic effects induced by dexamethasone and zoledronic_acid on multiple_myeloma cells .
15145616	0	dexamethasone	99,112	IL-6	139,143	dexamethasone	IL-6	MESH:D003907	3569	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|production production|compound|END_ENTITY	Corticosteroid resistance in a subpopulation of multiple_sclerosis patients as measured by ex vivo dexamethasone inhibition of LPS induced IL-6 production .
15383370	4	dexamethasone	1301,1314	IL-6	1332,1336	dexamethasone	IL-6	MESH:D003907	3569	Chemical	Gene	addition|nmod|START_ENTITY reduced|nmod|addition reduced|ccomp|blunted blunted|nsubj|END_ENTITY	IL-6 treatment alone increased -LRB- P < 0.05 -RRB- lipolysis , but this effect was reduced by the addition of dexamethasone and GH such that IL-6 plus dexamethasone and GH had blunted -LRB- P < 0.05 -RRB- lipolysis compared with IL-6 alone .
1550404	10	dexamethasone	1408,1421	IL-6	1498,1502	dexamethasone	IL-6	MESH:D003907	3569	Chemical	Gene	suppressed|nsubj|START_ENTITY suppressed|advcl|increase increase|dobj|expression expression|nmod|mRNA mRNA|compound|END_ENTITY	In contrast , dexamethasone -LRB- 10 -LRB- -6 -RRB- mol/l -RRB- suppressed the ability of IL-1 to increase the expression of IL-6 mRNA .
16857895	0	dexamethasone	5,18	IL-6	86,90	dexamethasone	IL-6	MESH:D003907	3569	Chemical	Gene	concentration|compound|START_ENTITY prevents|nsubj|concentration prevents|nmod|secretion secretion|compound|END_ENTITY	High dexamethasone concentration prevents stimulatory effects of TNF-alpha and LPS on IL-6 secretion from the precursors of human muscle regeneration .
22289904	6	dexamethasone	1102,1115	IL-6	1174,1178	dexamethasone	IL-6	MESH:D003907	3569	Chemical	Gene	START_ENTITY|acl|led led|nmod|decrease decrease|nmod|expression expression|nmod|END_ENTITY	RESULTS : Pretreatment with dexamethasone led to a significant decrease in myocardial expression of IL-6 , IL-8 , IL-1b , and TNF-a messenger RNA and to a decrease in protein synthesis of TNF-a .
23771534	0	dexamethasone	41,54	IL-6	58,62	dexamethasone	IL-6	MESH:D003907	3569	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	MIF attenuates the suppressive effect of dexamethasone on IL-6 production by nasal polyp .
23791923	0	dexamethasone	20,33	IL-6	112,116	dexamethasone	IL-6	MESH:D003907	3569	Chemical	Gene	effects|nmod|START_ENTITY effects|acl|functional functional|dobj|secretion secretion|nmod|END_ENTITY	Opposing effects of dexamethasone , agrin and sugammadex on functional innervation and constitutive secretion of IL-6 in in vitro innervated primary human muscle cells .
23954444	0	dexamethasone	53,66	IL-6	48,52	dexamethasone	IL-6	MESH:D003907	3569	Chemical	Gene	START_ENTITY|nsubj|Prevention Prevention|nmod|apoptosis apoptosis|nmod|/ /|compound|END_ENTITY	Prevention of Reg I-induced b-cell apoptosis by IL-6 / dexamethasone through activation of HGF gene regulation .
7647014	0	dexamethasone	105,118	IL-6	28,32	dexamethasone	IL-6	MESH:D003907	3569	Chemical	Gene	effect|nmod|START_ENTITY reverse|dobj|effect reverse|nsubj|family family|acl:relcl|cytokines cytokines|dobj|END_ENTITY	The gp_130 family cytokines IL-6 , LIF and OSM but not IL-11 can reverse the anti-proliferative effect of dexamethasone on human myeloma cells .
8933213	0	dexamethasone	14,27	IL-6	74,78	dexamethasone	IL-6	MESH:D003907	3569	Chemical	Gene	START_ENTITY|nmod|increase increase|nmod|abundance abundance|compound|END_ENTITY	Inhibition by dexamethasone of the lipopolysaccharide-induced increase in IL-6 mRNA abundance and IL-6 production in human polymorphonuclear leukocytes .
10227335	0	dexamethasone	82,95	IL-8	19,23	dexamethasone	IL-8	MESH:D003907	3576	Chemical	Gene	effect|nmod|START_ENTITY induces|parataxis|effect induces|dobj|production production|compound|END_ENTITY	Grain dust induces IL-8 production from bronchial epithelial cells : the effect of dexamethasone on IL-8 production .
10227335	0	dexamethasone	82,95	IL-8	99,103	dexamethasone	IL-8	MESH:D003907	3576	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Grain dust induces IL-8 production from bronchial epithelial cells : the effect of dexamethasone on IL-8 production .
10227335	9	dexamethasone	1726,1739	IL-8	1795,1799	dexamethasone	IL-8	MESH:D003907	3576	Chemical	Gene	pretreatment|nmod|START_ENTITY induced|nsubj|pretreatment induced|dobj|inhibitions inhibitions|nmod|production production|compound|END_ENTITY	Compared with the untreated sample , pretreatment of dexamethasone could induced a remarkable inhibitions -LRB- 15 % to 55 % -RRB- of IL-8 production from bronchial epithelial cells in a dose-dependent manner .
1325308	0	dexamethasone	114,127	IL-8	58,62	dexamethasone	IL-8	MESH:D003907	3576	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|pathways pathways|acl|leading leading|nmod|production production|nmod|END_ENTITY	Signal transduction pathways leading to the production of IL-8 by human monocytes are differentially regulated by dexamethasone .
25019304	0	dexamethasone	37,50	Icam-1	0,6	dexamethasone	Icam-1	MESH:D003907	15894(Tax:10090)	Chemical	Gene	pulmonary_inflammation|amod|START_ENTITY loaded|nmod|pulmonary_inflammation loaded|nsubj|nanogels nanogels|amod|END_ENTITY	Icam-1 targeted nanogels loaded with dexamethasone alleviate pulmonary_inflammation .
14966043	0	dexamethasone	66,79	Insulin	0,7	dexamethasone	Insulin	MESH:D003907	3630	Chemical	Gene	abolished|nmod|START_ENTITY abolished|nsubjpass|increase increase|amod|END_ENTITY	Insulin induced increase in coronary flow reserve is abolished by dexamethasone in young men with uncomplicated type 1 diabetes .
6149850	0	dexamethasone	61,74	Insulin	0,7	dexamethasone	Insulin	MESH:D003907	396145(Tax:9031)	Chemical	Gene	induction|nmod|START_ENTITY inhibition|nmod|induction inhibition|compound|END_ENTITY	Insulin inhibition of tyrosine aminotransferase induction by dexamethasone is species-related .
8522065	0	dexamethasone	78,91	Insulin	0,7	dexamethasone	Insulin	MESH:D003907	483665(Tax:9615)	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|transport transport|compound|END_ENTITY	Insulin transport from plasma into the central nervous system is inhibited by dexamethasone in dogs .
9342790	0	dexamethasone	15,28	Insulin	0,7	dexamethasone	Insulin	MESH:D003907	280829(Tax:9913)	Chemical	Gene	START_ENTITY|nsubj|and/or and/or|compound|END_ENTITY	Insulin and/or dexamethasone regulation of lactate production and its relationship to glucose utilization by ovine and bovine adipose_tissue explants incubated for 7 days .
8221802	0	dexamethasone	56,69	Interleukin-1_beta	0,18	dexamethasone	Interleukin-1 beta	MESH:D003907	3553	Chemical	Gene	production|amod|START_ENTITY myocardial_contraction|nmod|production modulates|dobj|myocardial_contraction modulates|nsubj|END_ENTITY	Interleukin-1_beta modulates myocardial_contraction via dexamethasone sensitive production of nitric_oxide .
15324484	0	dexamethasone	10,23	L-FABP	60,66	dexamethasone	L-FABP	MESH:D003907	24360(Tax:10116)	Chemical	Gene	Effect|acl|START_ENTITY Effect|nmod|END_ENTITY	Effect of dexamethasone , 2-bromopalmitate and clofibrate on L-FABP mediated hepatoma proliferation .
10959555	0	dexamethasone	30,43	LFA-3	14,19	dexamethasone	LFA-3	MESH:D003907	965	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of LFA-3 -LRB- CD58 -RRB- by dexamethasone and retinoic_acids in vitro .
16305819	0	dexamethasone	39,52	Leptin	0,6	dexamethasone	Leptin	MESH:D003907	100034042(Tax:9796)	Chemical	Gene	effects|nmod|START_ENTITY secretion|dep|effects secretion|compound|END_ENTITY	Leptin secretion in horses : effects of dexamethasone , gender , and testosterone .
7536934	0	dexamethasone	40,53	Lipocortin_1	0,12	dexamethasone	Lipocortin 1	MESH:D003907	25380(Tax:10116)	Chemical	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Lipocortin_1 mediates the inhibition by dexamethasone of the induction by endotoxin of nitric_oxide synthase in the rat .
26279163	0	dexamethasone	10,23	MAFbx	55,60	dexamethasone	MAFbx	MESH:D003907	114907	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|END_ENTITY	Effect of dexamethasone on the expression of atrogin-1 / MAFbx in chick skeletal muscle .
26279163	0	dexamethasone	10,23	MAFbx	55,60	dexamethasone	MAFbx	MESH:D003907	114907	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|END_ENTITY	Effect of dexamethasone on the expression of atrogin-1 / MAFbx in chick skeletal muscle .
18845168	0	dexamethasone	68,81	MAP_kinase_phosphatase-1	12,36	dexamethasone	MAP kinase phosphatase-1	MESH:D003907	19252(Tax:10090)	Chemical	Gene	mechanism|nmod|START_ENTITY END_ENTITY|nmod|mechanism	The role of MAP_kinase_phosphatase-1 in the protective mechanism of dexamethasone against endotoxemia .
16494108	0	dexamethasone	99,112	MDR1	50,54	dexamethasone	MDR1	MESH:D003907	5243	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY influence|dobj|pharmacokinetics influence|nsubj|polymorphism polymorphism|appos|END_ENTITY	The polymorphism of multi-drug_resistance_1 gene -LRB- MDR1 -RRB- does not influence the pharmacokinetics of dexamethasone loaded into autologous erythrocytes of patients with inflammatory_bowel_disease .
9826540	0	dexamethasone	43,56	MDR1	14,18	dexamethasone	MDR1	MESH:D003907	5243	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Modulation of MDR1 and CYP3A expression by dexamethasone : evidence for an inverse regulation in adrenals .
12110372	0	dexamethasone	146,159	MRP2	127,131	dexamethasone	MRP2	MESH:D003907	25303(Tax:10116)	Chemical	Gene	induction|nmod|START_ENTITY induction|nmod|expression expression|compound|END_ENTITY	Coordinate regulation of UDP-glucuronosyltransferase UGT1A6 induction by 3-methylcholanthrene and multidrug resistance protein MRP2 expression by dexamethasone in primary rat hepatocytes .
24772975	0	dexamethasone	10,23	MTJ1	60,64	dexamethasone	MTJ1	MESH:D003907	64215	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of dexamethasone on unfolded protein response genes -LRB- MTJ1 , Grp78 , Grp94 , CHOP , HMOX-1 -RRB- in HEp2 cell line .
8680861	0	dexamethasone	59,72	Monoamine_oxidase_B	0,19	dexamethasone	Monoamine oxidase B	MESH:D003907	25750(Tax:10116)	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|compound|END_ENTITY	Monoamine_oxidase_B expression is selectively regulated by dexamethasone in cultured rat astrocytes .
15361359	0	dexamethasone	11,24	Muc5ac	28,34	dexamethasone	Muc5ac	MESH:D003907	4586	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|production production|amod|END_ENTITY	Effects of dexamethasone on Muc5ac mucin production by primary airway goblet cells .
12072429	7	dexamethasone	1261,1274	NDRG2	1294,1299	dexamethasone	NDRG2	MESH:D003907	171114(Tax:10116)	Chemical	Gene	ineffective|nsubj|START_ENTITY ineffective|nmod|expression expression|compound|END_ENTITY	In contrast , the glucocorticoid dexamethasone was ineffective in NDRG2 expression , whereas the glucocorticoid-regulated gene sgk was induced .
9452998	0	dexamethasone	82,95	NOS2	63,67	dexamethasone	NOS2	MESH:D003907	24599(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Involvement of transcriptional mechanisms in the inhibition of NOS2 expression by dexamethasone in rat mesangial cells .
1325811	0	dexamethasone	104,117	Neutral_endopeptidase	0,21	dexamethasone	Neutral endopeptidase	MESH:D003907	4311	Chemical	Gene	accelerates|nsubj|START_ENTITY recovers|parataxis|accelerates recovers|nsubj|END_ENTITY	Neutral_endopeptidase of a human airway epithelial cell line recovers after hypochlorous_acid exposure : dexamethasone accelerates this by stimulating neutral_endopeptidase mRNA synthesis .
23860121	0	dexamethasone	63,76	Nhe1	55,59	dexamethasone	Nhe1	MESH:D003907	20544(Tax:10090)	Chemical	Gene	+|nmod|START_ENTITY +|dobj|END_ENTITY	Sgk1-dependent stimulation of cardiac Na + / H + exchanger Nhe1 by dexamethasone .
7560060	0	dexamethasone	96,109	P-Glycoprotein	21,35	dexamethasone	P-Glycoprotein	MESH:D003907	5243	Chemical	Gene	distribution|nmod|START_ENTITY affects|dobj|distribution affects|nsubj|Absence Absence|nmod|END_ENTITY	Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone , digoxin , and cyclosporin_A .
11159804	0	dexamethasone	140,153	P-glycoprotein	90,104	dexamethasone	P-glycoprotein	MESH:D003907	287115(Tax:10116)	Chemical	Gene	pretreated|nmod|START_ENTITY rats|acl|pretreated P450|nmod|rats P450|nmod|rhodamine_123 rhodamine_123|appos|substrate substrate|amod|END_ENTITY	Pharmacokinetic interaction of cytochrome P450 3A-related compounds with rhodamine_123 , a P-glycoprotein substrate , in rats pretreated with dexamethasone .
16384676	0	dexamethasone	126,139	P-glycoprotein	28,42	dexamethasone	P-glycoprotein	MESH:D003907	67078(Tax:10090)	Chemical	Gene	treated|nmod|START_ENTITY Contributions|acl|treated Contributions|nmod|END_ENTITY	Contributions of intestinal P-glycoprotein and CYP3A to oral bioavailability of cyclosporin_A in mice treated with or without dexamethasone .
18556350	0	dexamethasone	63,76	P-glycoprotein	19,33	dexamethasone	P-glycoprotein	MESH:D003907	67078(Tax:10090)	Chemical	Gene	distribution|nmod|START_ENTITY END_ENTITY|nmod|distribution	A revised role for P-glycoprotein in the brain distribution of dexamethasone , cortisol , and corticosterone in wild-type and ABCB1A/B-deficient mice .
20940624	0	dexamethasone	119,132	P-glycoprotein	0,14	dexamethasone	P-glycoprotein	MESH:D003907	5243	Chemical	Gene	levels|compound|START_ENTITY correlated|nmod|levels correlated|nsubjpass|expression expression|amod|END_ENTITY	P-glycoprotein transporter expression on a549 respiratory epithelial cells is positively correlated with intracellular dexamethasone levels .
8101494	0	dexamethasone	14,27	P-glycoprotein	31,45	dexamethasone	P-glycoprotein	MESH:D003907	287115(Tax:10116)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation by dexamethasone of P-glycoprotein expression in cultured rat hepatocytes .
9855321	0	dexamethasone	20,33	P-glycoprotein	51,65	dexamethasone	P-glycoprotein	MESH:D003907	5243	Chemical	Gene	START_ENTITY|appos|modulator modulator|compound|END_ENTITY	Pharmacokinetics of dexamethasone and valspodar , a P-glycoprotein -LRB- mdr1 -RRB- modulator : implications for coadministration .
8612525	0	dexamethasone	157,170	P450	131,135	dexamethasone	P450	MESH:D003907	1555	Chemical	Gene	synergistically|nmod|START_ENTITY synergistically|compound|END_ENTITY	1,25-Dihydroxyvitamin _ D3 enhances the enzymatic activity and expression of the messenger ribonucleic_acid for aromatase cytochrome P450 synergistically with dexamethasone depending on the vitamin_D_receptor level in cultured human osteoblasts .
1360848	0	dexamethasone	26,39	PCNA	87,91	dexamethasone	PCNA	MESH:D003907	5111	Chemical	Gene	START_ENTITY|nmod|expression expression|appos|END_ENTITY	Influence of preoperative dexamethasone therapy on proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- expression in comparison to other parameters in meningiomas .
2260483	0	dexamethasone	23,36	Prolactin	0,9	dexamethasone	Prolactin	MESH:D003907	5617	Chemical	Gene	suppression|amod|START_ENTITY responses|nmod|suppression responses|compound|END_ENTITY	Prolactin responses in dexamethasone suppression test in patients with anorexia_nervosa .
3673636	0	dexamethasone	22,35	Prolactin	0,9	dexamethasone	Prolactin	MESH:D003907	5617	Chemical	Gene	response|acl|START_ENTITY response|compound|END_ENTITY	Prolactin response to dexamethasone : a study on normal controls and depressed patients .
576342	0	dexamethasone	83,96	Prolactin	0,9	dexamethasone	Prolactin	MESH:D003907	5617	Chemical	Gene	test|nmod|START_ENTITY test|nsubj|levels levels|compound|END_ENTITY	Prolactin levels in the insulin tolerance test with and without pre-treatment with dexamethasone .
8931912	0	dexamethasone	31,44	Prolactin	0,9	dexamethasone	Prolactin	MESH:D003907	5617	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Prolactin response to low-dose dexamethasone challenge in combat-exposed veterans with and without posttraumatic_stress_disorder and normal controls .
8630883	0	dexamethasone	67,80	Prostate_specific_antigen	0,25	dexamethasone	Prostate specific antigen	MESH:D003907	354	Chemical	Gene	START_ENTITY|nsubj|levels levels|compound|END_ENTITY	Prostate_specific_antigen levels and clinical response to low dose dexamethasone for hormone-refractory metastatic prostate_carcinoma .
22422618	0	dexamethasone	44,57	Runx2	26,31	dexamethasone	Runx2	MESH:D003907	12393(Tax:10090)	Chemical	Gene	mediated|nmod|START_ENTITY END_ENTITY|acl|mediated	Down-regulation of type I Runx2 mediated by dexamethasone is required for 3T3-L1 adipogenesis .
17609160	0	dexamethasone	66,79	SET_and_MYND_domain-containing_protein_3	0,40	dexamethasone	SET and MYND domain-containing protein 3	MESH:D003907	69726(Tax:10090)	Chemical	Gene	decreases|nmod|START_ENTITY decreases|nsubj|END_ENTITY	SET_and_MYND_domain-containing_protein_3 decreases sensitivity to dexamethasone and stimulates cell adhesion and migration in NIH3T3 cells .
2015097	0	dexamethasone	20,33	SP-A	51,55	dexamethasone	SP-A	MESH:D003907	24773(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effects of maternal dexamethasone on expression of SP-A , SP-B , and SP-C in the fetal rat lung .
10810294	0	dexamethasone	149,162	Stat5	112,117	dexamethasone	Stat5	MESH:D003907	6776	Chemical	Gene	effect|nmod|START_ENTITY effect|amod|END_ENTITY	Stimulation of endogenous GH and interleukin-6 receptors selectively activates different Jaks and Stats , with a Stat5 specific synergistic effect of dexamethasone .
16887961	0	dexamethasone	14,27	Syk	49,52	dexamethasone	Syk	MESH:D003907	25155(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Cutting edge : dexamethasone negatively regulates Syk in mast cells by up-regulating SRC-like_adaptor protein .
9059990	0	dexamethasone	10,23	T-cell_receptor	27,42	dexamethasone	T-cell receptor	MESH:D003907	6962	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of dexamethasone on T-cell_receptor / CD3 expression .
22074830	0	dexamethasone	81,94	TDAG8	39,44	dexamethasone	TDAG8	MESH:D003907	8477	Chemical	Gene	actions|nmod|START_ENTITY END_ENTITY|nmod|actions	Involvement of proton-sensing receptor TDAG8 in the anti-inflammatory actions of dexamethasone in peritoneal macrophages .
8679249	0	dexamethasone	93,106	TGF-beta	135,143	dexamethasone	TGF-beta	MESH:D003907	7040	Chemical	Gene	START_ENTITY|dep|regulation regulation|nmod|END_ENTITY	Monocyte_chemotactic_protein-1 -LRB- MCP-1 -RRB- mRNA is down-regulated in human dermal fibroblasts by dexamethasone : differential regulation by TGF-beta .
16961297	0	dexamethasone	21,34	TGF-beta1	38,47	dexamethasone	TGF-beta1	MESH:D003907	100008645(Tax:9986)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Inhibitory effect of dexamethasone on TGF-beta1 expression of rabbit ciliary pigment epithelia cultured in vitro .
19629637	0	dexamethasone	22,35	TIMP-1	39,45	dexamethasone	TIMP-1	MESH:D003907	21857(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Suppressive effect of dexamethasone on TIMP-1 production involves murine osteoblastic MC3T3-E1 cell apoptosis .
10072973	0	dexamethasone	11,24	TNF_alpha	73,82	dexamethasone	TNF alpha	MESH:D003907	24835(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of dexamethasone and ibuprofen on LPS-induced gene expression of TNF_alpha , IL-1_beta , and MIP-1_alpha in rat lung .
10437167	0	dexamethasone	11,24	TNF_alpha	75,84	dexamethasone	TNF alpha	MESH:D003907	24835(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Effects of dexamethasone , cyproheptadine , anisodamine , and dinoprostone on TNF_alpha production in endotoxic_shock .
15389671	0	dexamethasone	113,126	TNF_alpha	0,9	dexamethasone	TNF alpha	MESH:D003907	24835(Tax:10116)	Chemical	Gene	measurement|nmod|START_ENTITY measurement|nsubj|END_ENTITY	TNF_alpha measurement in rat and human whole blood as an in vitro method to assay pyrogens and its inhibition by dexamethasone and erythromycin .
10736973	0	dexamethasone	69,82	TRH	106,109	dexamethasone	TRH	MESH:D003907	7200	Chemical	Gene	effect|nmod|START_ENTITY involvement|nmod|effect involvement|nmod|END_ENTITY	Dopaminergic and cholinergic involvement in the inhibitory effect of dexamethasone on the TSH response to TRH .
11478409	0	dexamethasone	10,23	TRH	52,55	dexamethasone	TRH	MESH:D003907	7200	Chemical	Gene	Effect|nmod|START_ENTITY induced|nsubj|Effect induced|nmod|END_ENTITY	Effect of dexamethasone on TSH secretion induced by TRH in human obesity .
23127400	0	dexamethasone	11,24	TWEAK	43,48	dexamethasone	TWEAK	MESH:D003907	21944(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expressions expressions|nmod|END_ENTITY	-LSB- Effect of dexamethasone on expressions of TWEAK and Fn14 in the lung of asthmatic mice -RSB- .
9440135	0	dexamethasone	91,104	Tumor_necrosis_factor-alpha	0,27	dexamethasone	Tumor necrosis factor-alpha	MESH:D003907	7124	Chemical	Gene	attenuation|nmod|START_ENTITY expression|dep|attenuation promotes|dobj|expression promotes|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha promotes sustained cyclooxygenase-2 expression : attenuation by dexamethasone and NSAIDs .
15560369	0	dexamethasone	86,99	UDP-glucuronosyltransferase_1A1	51,82	dexamethasone	UDP-glucuronosyltransferase 1A1	MESH:D003907	54658	Chemical	Gene	Stimulation|nmod|START_ENTITY Stimulation|nmod|END_ENTITY	Stimulation of transcriptional expression of human UDP-glucuronosyltransferase_1A1 by dexamethasone .
12485811	0	dexamethasone	72,85	VEGF	27,31	dexamethasone	VEGF	MESH:D003907	22339(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY adrenal_atrophy|acl|induced receptors|nmod|adrenal_atrophy receptors|amod|END_ENTITY	Differential expression of VEGF receptors in adrenal_atrophy induced by dexamethasone : a protective role of ACTH .
17906365	0	dexamethasone	156,169	VEGF	26,30	dexamethasone	VEGF	MESH:D003907	7422	Chemical	Gene	effect|nmod|START_ENTITY expression|dep|effect expression|compound|END_ENTITY	Impaired TNFalpha-induced VEGF expression in human airway smooth muscle cells from smokers with COPD : role of MAPkinases and histone acetylation -- effect of dexamethasone .
10516393	0	dexamethasone	114,127	Vascular_endothelial_growth_factor	0,34	dexamethasone	Vascular endothelial growth factor	MESH:D003907	7422	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|dep|effects	Vascular_endothelial_growth_factor in pulmonary lavage fluid from premature infants : effects of age and postnatal dexamethasone .
18758056	0	dexamethasone	10,23	Ym1/2	43,48	dexamethasone	Ym1/2	MESH:D003907	12655;104183	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of dexamethasone on STAT6-dependent Ym1/2 expression in vivo and in vitro .
17335662	0	dexamethasone	10,23	adiponectin	140,151	dexamethasone	adiponectin	MESH:D003907	9370	Chemical	Gene	Effect|nmod|START_ENTITY adipocytes|nsubj|Effect adipocytes|nmod|END_ENTITY	Effect of dexamethasone on peroxisome_proliferator_activated_receptor-gamma mRNA expression in 3T3-L1 adipocytes with the human recombinant adiponectin .
18363889	0	dexamethasone	94,107	adiponectin	29,40	dexamethasone	adiponectin	MESH:D003907	9370	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Adiponectin , skeletal muscle adiponectin receptor expression and insulin resistance following dexamethasone .
11484195	0	dexamethasone	54,67	alkaline_phosphatase	75,95	dexamethasone	alkaline phosphatase	MESH:D003907	250	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Comparative effects of nacre water-soluble matrix and dexamethasone on the alkaline_phosphatase activity of MRC-5 fibroblasts .
11490095	0	dexamethasone	155,168	alpha-2-macroglobulin	93,114	dexamethasone	alpha-2-macroglobulin	MESH:D003907	24153(Tax:10116)	Chemical	Gene	changes|amod|START_ENTITY changes|amod|END_ENTITY	The responses of rat liver glucocorticoid receptors and genes for tyrosine_aminotransferase , alpha-2-macroglobulin and gamma-fibrinogen to adrenalectomy - , dexamethasone - and inflammation-induced changes in the levels of glucocorticoids and proinflammatory cytokines .
2420790	0	dexamethasone	17,30	alpha-fetoprotein	41,58	dexamethasone	alpha-fetoprotein	MESH:D003907	24177(Tax:10116)	Chemical	Gene	effect|amod|START_ENTITY effect|nmod|expression expression|amod|END_ENTITY	Mechanism of the dexamethasone effect on alpha-fetoprotein gene expression in McA-RH8994 rat hepatoma cells .
2431944	0	dexamethasone	92,105	alpha-fetoprotein	14,31	dexamethasone	alpha-fetoprotein	MESH:D003907	24177(Tax:10116)	Chemical	Gene	Activation|acl|START_ENTITY Activation|nmod|synthesis synthesis|amod|END_ENTITY	Activation of alpha-fetoprotein synthesis in rat hepatoma cells with reduced sensitivity to dexamethasone .
2462558	0	dexamethasone	62,75	alpha-fetoprotein	30,47	dexamethasone	alpha-fetoprotein	MESH:D003907	174	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Transcriptional regulation of alpha-fetoprotein expression by dexamethasone in human hepatoma cells .
92316	0	dexamethasone	27,40	alpha-fetoprotein	56,73	dexamethasone	alpha-fetoprotein	MESH:D003907	24177(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|amod|END_ENTITY	The antagonistic effect of dexamethasone and insulin on alpha-fetoprotein secretion by cultured H4-II-E-C3 cells derived from the Reuber H-35 hepatoma .
9628324	0	dexamethasone	132,145	alpha-fetoprotein	106,123	dexamethasone	alpha-fetoprotein	MESH:D003907	24177(Tax:10116)	Chemical	Gene	studying|nmod|START_ENTITY studying|dobj|regulation regulation|dep|down-regulation down-regulation|nmod|gene gene|amod|END_ENTITY	Rat yolk sac explants as a system for studying the regulation of endodermal genes : down-regulation of the alpha-fetoprotein gene by dexamethasone and phorbol_ester .
8256657	0	dexamethasone	117,130	annexin_I	14,23	dexamethasone	annexin I	MESH:D003907	25380(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY stimulation|nmod|expression Expression|dep|stimulation Expression|nmod|END_ENTITY	Expression of annexin_I , II , V , and VI by rat osteoblasts in primary culture : stimulation of annexin_I expression by dexamethasone .
8256657	0	dexamethasone	117,130	annexin_I	93,102	dexamethasone	annexin I	MESH:D003907	25380(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Expression of annexin_I , II , V , and VI by rat osteoblasts in primary culture : stimulation of annexin_I expression by dexamethasone .
8706754	11	dexamethasone	2032,2045	apoA-I	2003,2009	dexamethasone	apoA-I	MESH:D003907	25081(Tax:10116)	Chemical	Gene	transcription|nmod|START_ENTITY transcription|amod|END_ENTITY	In addition , the induction of apoA-I gene transcription by dexamethasone was blocked by the protein-synthesis inhibitor cycloheximide , which suggests the presence of a labile protein involved in apoA-I gene activation by dexamethasone .
3119648	0	dexamethasone	15,28	apolipoprotein_A-1	72,90	dexamethasone	apolipoprotein A-1	MESH:D003907	335	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of dexamethasone and anencephaly on newborn serum levels of apolipoprotein_A-1 .
7670964	0	dexamethasone	11,24	apolipoprotein_B	73,89	dexamethasone	apolipoprotein B	MESH:D003907	54225(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|synthesis synthesis|nmod|END_ENTITY	Effects of dexamethasone on the synthesis , degradation , and secretion of apolipoprotein_B in cultured rat hepatocytes .
16696342	0	dexamethasone	21,34	aquaporin-1	38,49	dexamethasone	aquaporin-1	MESH:D003907	282653(Tax:9913)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|amod|END_ENTITY	Regulatory effect of dexamethasone on aquaporin-1 expression in cultured bovine trabecular meshwork cells .
16711029	0	dexamethasone	10,23	aquaporin-1	74,85	dexamethasone	aquaporin-1	MESH:D003907	358	Chemical	Gene	antisense|amod|START_ENTITY Effect|nmod|antisense oligonucleotides|nsubj|Effect oligonucleotides|nmod|expression expression|amod|END_ENTITY	Effect of dexamethasone and aquaporin-1 antisense oligonucleotides on the aquaporin-1 expression in cultured human trabecular meshwork cells .
14669532	0	dexamethasone	99,112	aquaporin-3	26,37	dexamethasone	aquaporin-3	MESH:D003907	65133(Tax:10116)	Chemical	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|expression expression|amod|END_ENTITY	Up-regulation of cochlear aquaporin-3 mRNA expression after intra-endolymphatic sac application of dexamethasone .
26045822	0	dexamethasone	11,24	aquaporin-4	28,39	dexamethasone	aquaporin-4	MESH:D003907	25293(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|amod|END_ENTITY	Effects of dexamethasone on aquaporin-4 expression in brain tissue of rat with bacterial_meningitis .
21224738	0	dexamethasone	21,34	arginine-vasopressin	38,58	dexamethasone	arginine-vasopressin	MESH:D003907	551	Chemical	Gene	START_ENTITY|nmod|release release|amod|END_ENTITY	Inhibitory effect of dexamethasone on arginine-vasopressin release induced by physical exercise in man .
26279163	0	dexamethasone	10,23	atrogin-1	45,54	dexamethasone	atrogin-1	MESH:D003907	420343(Tax:9031)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	Effect of dexamethasone on the expression of atrogin-1 / MAFbx in chick skeletal muscle .
26279163	0	dexamethasone	10,23	atrogin-1	45,54	dexamethasone	atrogin-1	MESH:D003907	420343(Tax:9031)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	Effect of dexamethasone on the expression of atrogin-1 / MAFbx in chick skeletal muscle .
18678970	0	dexamethasone	89,102	basic_fibroblast_growth_factor	18,48	dexamethasone	basic fibroblast growth factor	MESH:D003907	54250(Tax:10116)	Chemical	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	Co-treatment with basic_fibroblast_growth_factor and 17beta-estradiol in the presence of dexamethasone accelerates bone formation by rat bone marrow stromal cell culture .
8847894	0	dexamethasone	15,28	bcl-2	44,49	dexamethasone	bcl-2	MESH:D003907	596	Chemical	Gene	START_ENTITY|nmod|protein protein|amod|END_ENTITY	Sensitivity to dexamethasone and absence of bcl-2 protein in Burkitt 's _ lymphoma cell line -LRB- Black93 -RRB- derived from a patient with acute tumor_lysis_syndrome : comparative study with other BL and non-BL lines .
2157505	0	dexamethasone	41,54	beta-endorphin	20,34	dexamethasone	beta-endorphin	MESH:D003907	5443	Chemical	Gene	administration|amod|START_ENTITY END_ENTITY|nmod|administration	Cortisol , ACTH , and beta-endorphin after dexamethasone administration in Parkinson 's _ dementia .
2829262	0	dexamethasone	4,17	beta-endorphin	63,77	dexamethasone	beta-endorphin	MESH:D003907	5443	Chemical	Gene	test|amod|START_ENTITY test|dep|END_ENTITY	The dexamethasone and cortisol suppression test in depression : beta-endorphin as a useful marker .
3038984	0	dexamethasone	40,53	beta-endorphin	22,36	dexamethasone	beta-endorphin	MESH:D003907	5443	Chemical	Gene	suppressors|amod|START_ENTITY immunoreactive|nmod|suppressors immunoreactive|dobj|END_ENTITY	Plasma immunoreactive beta-endorphin in dexamethasone suppressors and non-suppressors of cortisol .
10547074	0	dexamethasone	144,157	beta1	204,209	dexamethasone	beta1	MESH:D003907	10678	Chemical	Gene	START_ENTITY|nmod|presence presence|nmod|END_ENTITY	Role of CD14 expression in the differentiation-apoptosis switch in human monocytic_leukemia cells treated with 1alpha,25-dihydroxyvitamin _ D3 or dexamethasone in the presence of transforming growth factor beta1 .
15714225	0	dexamethasone	63,76	c-Fos	15,20	dexamethasone	c-Fos	MESH:D003907	314322(Tax:10116)	Chemical	Gene	modulated|nmod|START_ENTITY modulated|nsubjpass|expression expression|amod|END_ENTITY	Stress-induced c-Fos expression is differentially modulated by dexamethasone , diazepam and imipramine .
7713192	0	dexamethasone	11,24	c-Fos	66,71	dexamethasone	c-Fos	MESH:D003907	2353	Chemical	Gene	Effects|nmod|START_ENTITY stimulated|nsubj|Effects stimulated|dobj|END_ENTITY	Effects of dexamethasone on cytokine and phorbol_ester stimulated c-Fos and c-Jun DNA binding and gene expression in human lung .
8783322	0	dexamethasone	36,49	c-Fos	119,124	dexamethasone	c-Fos	MESH:D003907	314322(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nsubj|effects	Enhanced effects of co-administered dexamethasone and diclofenac on inflammatory pain processing and associated spinal c-Fos expression in the rat .
9794429	0	dexamethasone	14,27	c-Jun_N-terminal_kinase	47,70	dexamethasone	c-Jun N-terminal kinase	MESH:D003907	116554(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Inhibition by dexamethasone of antigen-induced c-Jun_N-terminal_kinase activation in rat basophilic leukemia cells .
2144778	0	dexamethasone	91,104	c-fms	66,71	dexamethasone	c-fms	MESH:D003907	1436	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Inhibition of phorbol_ester-induced monocytic differentiation and c-fms gene expression by dexamethasone : potential involvement of arachidonic_acid metabolites .
7846733	0	dexamethasone	70,83	c-fms	35,40	dexamethasone	c-fms	MESH:D003907	1436	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Post-transcriptional regulation of c-fms proto-oncogene expression by dexamethasone and of CSF-1 in human breast_carcinomas in vitro .
17007911	0	dexamethasone	110,123	c-fos	31,36	dexamethasone	c-fos	MESH:D003907	314322(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY Alterations|nmod|treatment Alterations|nmod|immunolabelling immunolabelling|compound|END_ENTITY	Alterations of seizure-induced c-fos immunolabelling and gene expression in the rat cerebral cortex following dexamethasone treatment .
1939341	0	dexamethasone	65,78	c-fos	117,122	dexamethasone	c-fos	MESH:D003907	2353	Chemical	Gene	differentiation|nmod|START_ENTITY Inhibition|nmod|differentiation associated|nsubjpass|Inhibition associated|nmod|down-regulation down-regulation|nmod|END_ENTITY	Inhibition of phorbol_ester-induced monocytic differentiation by dexamethasone is associated with down-regulation of c-fos and c-jun -LRB- AP-1 -RRB- .
2599094	0	dexamethasone	20,33	calcitonin	53,63	dexamethasone	calcitonin	MESH:D003907	24241(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|level level|compound|END_ENTITY	Additive effects of dexamethasone and calcium on the calcitonin mRNA level in adrenalectomized rats .
16167129	0	dexamethasone	10,23	cardiac_troponin_T	41,59	dexamethasone	cardiac troponin T	MESH:D003907	7139	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|production production|compound|END_ENTITY	Effect of dexamethasone on postoperative cardiac_troponin_T production in pediatric cardiac surgery .
17412811	0	dexamethasone	50,63	clock	94,99	dexamethasone	clock	MESH:D003907	12753(Tax:10090)	Chemical	Gene	START_ENTITY|xcomp|minimize minimize|dobj|phase phase|nmod|rhythm rhythm|compound|END_ENTITY	Optimization of dosing schedule of daily inhalant dexamethasone to minimize phase shifting of clock gene expression rhythm in the lungs of the asthma mouse model .
20807668	0	dexamethasone	14,27	clock	31,36	dexamethasone	clock	MESH:D003907	100300400	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|levels levels|compound|END_ENTITY	The effect of dexamethasone on clock gene mRNA levels in bovine neutrophils and lymphocytes .
11922880	0	dexamethasone	81,94	corticotropin-releasing_factor	7,37	dexamethasone	corticotropin-releasing factor	MESH:D003907	1392	Chemical	Gene	test|amod|START_ENTITY END_ENTITY|nmod|test	Plasma corticotropin-releasing_factor in depressed patients before and after the dexamethasone suppression test .
2997567	0	dexamethasone	116,129	corticotropin-releasing_factor	33,63	dexamethasone	corticotropin-releasing factor	MESH:D003907	1392	Chemical	Gene	suppression|amod|START_ENTITY induces|nmod|suppression induces|nsubj|administration administration|nmod|END_ENTITY	Combined administration of human corticotropin-releasing_factor and lysine_vasopressin induces cortisol escape from dexamethasone suppression in healthy subjects .
3021441	0	dexamethasone	83,96	corticotropin-releasing_factor	18,48	dexamethasone	corticotropin-releasing factor	MESH:D003907	280755(Tax:9913)	Chemical	Gene	cells|nmod|START_ENTITY target|dobj|cells target|nsubj|Identification Identification|nmod|END_ENTITY	Identification of corticotropin-releasing_factor -LRB- CRF -RRB- target cells and effects of dexamethasone on binding in anterior pituitary using a fluorescent analog of CRF .
11516798	0	dexamethasone	14,27	cyclooxygenase-2	61,77	dexamethasone	cyclooxygenase-2	MESH:D003907	5743	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|mRNA mRNA|amod|END_ENTITY	The effect of dexamethasone on expression of mitogen-induced cyclooxygenase-2 mRNA by amnion-derived -LRB- WISH -RRB- cells .
11772429	0	dexamethasone	51,64	cyclooxygenase-2	2,18	dexamethasone	cyclooxygenase-2	MESH:D003907	29527(Tax:10116)	Chemical	Gene	inhibitor|advcl|START_ENTITY inhibitor|nsubj|END_ENTITY	A cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitor compared with dexamethasone in a survival study of rats with intracerebral 9L gliosarcomas .
16956425	0	dexamethasone	11,24	cyclooxygenase-2	80,96	dexamethasone	cyclooxygenase-2	MESH:D003907	5743	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|homeostasis homeostasis|nmod|mRNA mRNA|amod|END_ENTITY	Effects of dexamethasone and celecoxib on calcium homeostasis and expression of cyclooxygenase-2 mRNA in MG-63 human osteosarcoma cells .
9440135	0	dexamethasone	91,104	cyclooxygenase-2	47,63	dexamethasone	cyclooxygenase-2	MESH:D003907	5743	Chemical	Gene	attenuation|nmod|START_ENTITY expression|dep|attenuation expression|amod|END_ENTITY	Tumor_necrosis_factor-alpha promotes sustained cyclooxygenase-2 expression : attenuation by dexamethasone and NSAIDs .
9514889	0	dexamethasone	114,127	cyclooxygenase-2	131,147	dexamethasone	cyclooxygenase-2	MESH:D003907	5743	Chemical	Gene	START_ENTITY|nmod|cells cells|amod|END_ENTITY	Transcriptional role of the nuclear factor kappa B site in the induction by lipopolysaccharide and suppression by dexamethasone of cyclooxygenase-2 in U937 cells .
9822711	0	dexamethasone	63,76	cyclooxygenase-2	14,30	dexamethasone	cyclooxygenase-2	MESH:D003907	5743	Chemical	Gene	release|nmod|START_ENTITY release|amod|END_ENTITY	Repression of cyclooxygenase-2 and prostaglandin_E2 release by dexamethasone occurs by transcriptional and post-transcriptional mechanisms involving loss of polyadenylated mRNA .
24142710	0	dexamethasone	21,34	cysteine-rich_61_protein	52,76	dexamethasone	cysteine-rich 61 protein	MESH:D003907	16007(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Inhibitory effect of dexamethasone on expression of cysteine-rich_61_protein in airway epithelial cells of allergic_mouse models .
8421709	0	dexamethasone	50,63	cysteine-rich_intestinal_protein	14,46	dexamethasone	cysteine-rich intestinal protein	MESH:D003907	691657(Tax:10116)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of cysteine-rich_intestinal_protein by dexamethasone in the neonatal rat .
2880590	0	dexamethasone	10,23	cytochrome_P-450	27,43	dexamethasone	cytochrome P-450	MESH:D003907	25251(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|metabolism metabolism|amod|END_ENTITY	Effect of dexamethasone on cytochrome_P-450 mediated metabolism of 2-acetylaminofluorene in cultured rat hepatocytes .
3384091	0	dexamethasone	15,28	cytochrome_P450	63,78	dexamethasone	cytochrome P450	MESH:D003907	25251(Tax:10116)	Chemical	Gene	Phenobarbital|amod|START_ENTITY induce|nsubj|Phenobarbital induce|dobj|mRNAs mRNAs|amod|END_ENTITY	Phenobarbital , dexamethasone and benzanthracene induce several cytochrome_P450 mRNAs in rat hepatoma cells .
7773300	0	dexamethasone	70,83	cytochrome_P450	35,50	dexamethasone	cytochrome P450	MESH:D003907	25251(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Modulation of xenobiotic-inducible cytochrome_P450 gene expression by dexamethasone in primary rat hepatocytes .
7980651	0	dexamethasone	64,77	cytochrome_P450	23,38	dexamethasone	cytochrome P450	MESH:D003907	25251(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Biphasic regulation of cytochrome_P450 2B1/2 mRNA expression by dexamethasone in primary cultures of adult rat hepatocytes maintained on matrigel .
19022227	0	dexamethasone	11,24	cytochrome_P450_3A	87,105	dexamethasone	cytochrome P450 3A	MESH:D003907	1576	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|amod|END_ENTITY	Effects of dexamethasone , administered for growth promoting purposes , upon the hepatic cytochrome_P450_3A expression in the veal calf .
23339625	0	dexamethasone	105,118	cytochrome_P450_3A	62,80	dexamethasone	cytochrome P450 3A	MESH:D003907	170509(Tax:10116)	Chemical	Gene	changes|nmod|START_ENTITY changes|nmod|induction induction|nmod|END_ENTITY	Time-dependent changes in hepatic and intestinal induction of cytochrome_P450_3A after administration of dexamethasone to rats .
3601477	0	dexamethasone	92,105	elastin	8,15	dexamethasone	elastin	MESH:D003907	25043(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY Growth|dep|effects Growth|appos|concentration concentration|compound|END_ENTITY	Growth , elastin concentration , and collagen concentration of perinatal rat lung : effects of dexamethasone .
11339671	0	dexamethasone	20,33	endothelial_nitric_oxide_synthase	55,88	dexamethasone	endothelial nitric oxide synthase	MESH:D003907	24600(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effect of antenatal dexamethasone on the expression of endothelial_nitric_oxide_synthase in the lungs of postnatal pups .
12407540	0	dexamethasone	10,23	endothelin-1	33,45	dexamethasone	endothelin-1	MESH:D003907	24323(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|synthesis synthesis|amod|END_ENTITY	Antenatal dexamethasone enhances endothelin-1 synthesis and gene expression in the heart in congenital_diaphragmatic_hernia in rats .
8243548	0	dexamethasone	14,27	endothelin-1	78,90	dexamethasone	endothelin-1	MESH:D003907	100726197	Chemical	Gene	Relaxation|nmod|START_ENTITY precontracted|nsubj|Relaxation precontracted|advcl|END_ENTITY	Relaxation by dexamethasone of isolated guinea-pig airways precontracted with endothelin-1 .
9276131	0	dexamethasone	11,24	endothelin-1	73,85	dexamethasone	endothelin-1	MESH:D003907	100726197	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|release release|nmod|cells cells|amod|END_ENTITY	Effects of dexamethasone on the basal and cytokine-stimulated release of endothelin-1 from guinea-pig cultured tracheal epithelial cells .
21179697	0	dexamethasone	12,25	fibroblast_growth_factor_10	59,86	dexamethasone	fibroblast growth factor 10	MESH:D003907	14165(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of dexamethasone and vitamin_B12 on expression of fibroblast_growth_factor_10 and fibroblast_growth_factor_receptor_2b during early palatogenesis -RSB- .
2906869	0	dexamethasone	43,56	gamma-glutamyl_transferase	13,39	dexamethasone	gamma-glutamyl transferase	MESH:D003907	116568(Tax:10116)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of gamma-glutamyl_transferase by dexamethasone in cultured fetal rat hepatocytes .
8359553	0	dexamethasone	39,52	gastrin	70,77	dexamethasone	gastrin	MESH:D003907	100685087	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of short-term administration of dexamethasone on canine antral gastrin gene expression .
1651773	0	dexamethasone	79,92	glucocorticoid_receptor	10,33	dexamethasone	glucocorticoid receptor	MESH:D003907	2908	Chemical	Gene	autoregulation|acl|START_ENTITY autoregulation|compound|END_ENTITY	Disturbed glucocorticoid_receptor autoregulation and corticotropin response to dexamethasone in depressives pretreated with metyrapone .
16710999	0	dexamethasone	10,23	glucocorticoid_receptor	41,64	dexamethasone	glucocorticoid receptor	MESH:D003907	2908	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of dexamethasone on expression of glucocorticoid_receptor in human monocyte cell line THP-1 .
17606285	0	dexamethasone	144,157	glucocorticoid_receptor	39,62	dexamethasone	glucocorticoid receptor	MESH:D003907	2908	Chemical	Gene	separate|nmod|START_ENTITY regulates|ccomp|separate Comparison|parataxis|regulates Comparison|nmod|agonists agonists|compound|END_ENTITY	Comparison of two structurally diverse glucocorticoid_receptor agonists : cortivazol selectively regulates a distinct set of genes separate from dexamethasone in CEM cells .
18021564	0	dexamethasone	91,104	glucocorticoid_receptor	47,70	dexamethasone	glucocorticoid receptor	MESH:D003907	2908	Chemical	Gene	-RSB-|amod|START_ENTITY induced|nmod|-RSB- function|acl|induced function|compound|END_ENTITY	-LSB- P38 mitogen-activated protein kinase mediates glucocorticoid_receptor function induced by dexamethasone in acute_lymphoblastic_leukemia cells -RSB- .
1974259	0	dexamethasone	92,105	glucocorticoid_receptor	55,78	dexamethasone	glucocorticoid receptor	MESH:D003907	2908	Chemical	Gene	Suppression|nmod|START_ENTITY Suppression|nmod|synthesis synthesis|compound|END_ENTITY	Suppression of protein_kinase_C and the stimulation of glucocorticoid_receptor synthesis by dexamethasone in human fibroblasts derived from tumor tissue .
20922465	0	dexamethasone	102,115	glucocorticoid_receptor	64,87	dexamethasone	glucocorticoid receptor	MESH:D003907	2908	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Reciprocal regulation of 11b-hydroxysteroid dehydrogenase 1 and glucocorticoid_receptor expression by dexamethasone inhibits human coronary artery smooth muscle cell proliferation in vitro .
22189798	0	dexamethasone	46,59	glucocorticoid_receptor	13,36	dexamethasone	glucocorticoid receptor	MESH:D003907	2908	Chemical	Gene	Effects|amod|START_ENTITY Effects|nmod|END_ENTITY	Effects of a glucocorticoid_receptor agonist , dexamethasone , on fathead minnow reproduction , growth , and development .
22570346	0	dexamethasone	54,67	glucocorticoid_receptor	115,138	dexamethasone	glucocorticoid receptor	MESH:D003907	2908	Chemical	Gene	elevated|nmod|START_ENTITY elevated|ccomp|involve involve|dobj|END_ENTITY	Expression and activity of p-glycoprotein elevated by dexamethasone in cultured retinal pigment epithelium involve glucocorticoid_receptor and pregnane_X_receptor .
2438873	0	dexamethasone	72,85	glucocorticoid_receptor	104,127	dexamethasone	glucocorticoid receptor	MESH:D003907	2908	Chemical	Gene	fibroblasts|nmod|START_ENTITY metabolism|nmod|fibroblasts Modulation|nmod|metabolism Modulation|dep|correlation correlation|nmod|density density|compound|END_ENTITY	Modulation of collagen metabolism in cultured human skin fibroblasts by dexamethasone : correlation with glucocorticoid_receptor density .
26242202	0	dexamethasone	70,83	glucocorticoid_receptor	12,35	dexamethasone	glucocorticoid receptor	MESH:D003907	2908	Chemical	Gene	sensitivity|amod|START_ENTITY methylation|nmod|sensitivity methylation|nsubj|promoter promoter|compound|END_ENTITY	Endothelial glucocorticoid_receptor promoter methylation according to dexamethasone sensitivity .
7109574	0	dexamethasone	59,72	glucocorticoid_receptor	30,53	dexamethasone	glucocorticoid receptor	MESH:D003907	101844805	Chemical	Gene	resistant|amod|START_ENTITY melanoma|amod|resistant transformed|nmod|melanoma transformed|dobj|END_ENTITY	Identification of transformed glucocorticoid_receptor from dexamethasone resistant melanoma .
7118924	0	dexamethasone	29,42	glucocorticoid_receptor	66,89	dexamethasone	glucocorticoid receptor	MESH:D003907	2908	Chemical	Gene	the|nmod|START_ENTITY the|acl|mammary mammary|dobj|END_ENTITY	Inhibition of the binding of dexamethasone to mammary cytoplasmic glucocorticoid_receptor by phenylglyoxal .
7464144	0	dexamethasone	26,39	glucocorticoid_receptor	55,78	dexamethasone	glucocorticoid receptor	MESH:D003907	2908	Chemical	Gene	cells|amod|START_ENTITY cells|amod|binding binding|nmod|END_ENTITY	Competitive inhibition of dexamethasone binding to the glucocorticoid_receptor in HTC cells by tryptophan_methyl_ester .
7482631	0	dexamethasone	14,27	glucocorticoid_receptor	45,68	dexamethasone	glucocorticoid receptor	MESH:D003907	2908	Chemical	Gene	Inhibition|nmod|START_ENTITY binding|nsubj|Inhibition binding|nmod|END_ENTITY	Inhibition of dexamethasone binding to human glucocorticoid_receptor by New World primate cell extracts .
1456068	0	dexamethasone	14,27	glucocorticoid_receptors	76,100	dexamethasone	glucocorticoid receptors	MESH:D003907	24413(Tax:10116)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	-LSB- Influence of dexamethasone and epinephrine on glycogen content and cytosol glucocorticoid_receptors in hyperthyroid rat liver -RSB- .
8897851	0	dexamethasone	19,32	glucose_transport	48,65	dexamethasone	glucose transport	MESH:D003907	25139(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	In vivo effects of dexamethasone and sucrose on glucose_transport -LRB- GLUT-4 -RRB- protein tissue distribution .
19349622	0	dexamethasone	96,109	granulocyte_colony-stimulating_factor	58,95	dexamethasone	granulocyte colony-stimulating factor	MESH:D003907	1440	Chemical	Gene	mobilization|amod|START_ENTITY Changes|dep|mobilization Changes|nmod|granulocytes granulocytes|nmod|END_ENTITY	Changes in gene expression of granulocytes during in vivo granulocyte_colony-stimulating_factor / dexamethasone mobilization for transfusion purposes .
24738975	0	dexamethasone	166,179	granulocyte_colony-stimulating_factor	13,50	dexamethasone	granulocyte colony-stimulating factor	MESH:D003907	1440	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|END_ENTITY	Intermittent granulocyte_colony-stimulating_factor for neutropenia management in patients with relapsed or refractory multiple_myeloma treated with lenalidomide plus dexamethasone .
1624675	0	dexamethasone	115,128	growth_hormone	7,21	dexamethasone	growth hormone	MESH:D003907	2688	Chemical	Gene	pretreatment|amod|START_ENTITY effect|nmod|pretreatment patients|dep|effect corticotropin-releasing_hormone|nmod|patients END_ENTITY|advcl|corticotropin-releasing_hormone	Plasma growth_hormone -LRB- GH -RRB- responses to corticotropin-releasing_hormone in patients with acromegaly -- the effect of dexamethasone pretreatment and the comparison with GH responses to thyrotropin-releasing_hormone , gonadotropin-releasing_hormone and GH-releasing_hormone .
1675015	0	dexamethasone	84,97	growth_hormone	48,62	dexamethasone	growth hormone	MESH:D003907	2688	Chemical	Gene	-RSB-|amod|START_ENTITY induced|nmod|-RSB- Lack|acl|induced Lack|nmod|secretion secretion|amod|END_ENTITY	-LSB- Lack of effect of the administration of TRH on growth_hormone secretion induced by dexamethasone -RSB- .
1740962	0	dexamethasone	23,36	growth_hormone	81,95	dexamethasone	growth hormone	MESH:D003907	81668(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|potentiation potentiation|nmod|END_ENTITY	Negative regulation by dexamethasone of the potentiation of neuromedin_C-induced growth_hormone and prolactin release by estradiol in anterior pituitary cell aggregates .
17974466	0	dexamethasone	12,25	growth_hormone	29,43	dexamethasone	growth hormone	MESH:D003907	2688	Chemical	Gene	START_ENTITY|nmod|response response|amod|END_ENTITY	-LSB- Effects of dexamethasone on growth_hormone response in insulin_dependent_diabetes_mellitus -RSB- .
1993081	0	dexamethasone	67,80	growth_hormone	39,53	dexamethasone	growth hormone	MESH:D003907	81668(Tax:10116)	Chemical	Gene	density|nmod|START_ENTITY density|nmod|induction induction|nmod|receptors receptors|amod|END_ENTITY	Effect of cell density on induction of growth_hormone receptors by dexamethasone in primary cultured rat hepatocytes .
2105096	0	dexamethasone	17,30	growth_hormone	34,48	dexamethasone	growth hormone	MESH:D003907	2688	Chemical	Gene	influence|nmod|START_ENTITY influence|nmod|END_ENTITY	The influence of dexamethasone on growth_hormone -LRB- GH -RRB- .
21777655	0	dexamethasone	196,209	growth_hormone	37,51	dexamethasone	growth hormone	MESH:D003907	2688	Chemical	Gene	hormone|compound|START_ENTITY effects|nmod|hormone Transgenic_mice|dep|effects Transgenic_mice|acl|expressing expressing|ccomp|provide provide|nsubj|gene gene|compound|END_ENTITY	Transgenic_mice expressing the human growth_hormone gene provide a model system to study human growth_hormone synthesis and secretion in non-tumor-derived pituitary cells : differential effects of dexamethasone and thyroid hormone .
21777655	0	dexamethasone	196,209	growth_hormone	95,109	dexamethasone	growth hormone	MESH:D003907	2688	Chemical	Gene	hormone|compound|START_ENTITY effects|nmod|hormone Transgenic_mice|dep|effects Transgenic_mice|acl|expressing expressing|ccomp|provide provide|xcomp|study study|dobj|synthesis synthesis|amod|END_ENTITY	Transgenic_mice expressing the human growth_hormone gene provide a model system to study human growth_hormone synthesis and secretion in non-tumor-derived pituitary cells : differential effects of dexamethasone and thyroid hormone .
2836185	0	dexamethasone	20,33	growth_hormone	37,51	dexamethasone	growth hormone	MESH:D003907	2688	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|release release|amod|END_ENTITY	Biphasic effects of dexamethasone on growth_hormone release in vitro .
3018491	0	dexamethasone	77,90	growth_hormone	124,138	dexamethasone	growth hormone	MESH:D003907	2688	Chemical	Gene	START_ENTITY|nmod|intron intron|nmod|gene gene|compound|END_ENTITY	Glucocorticoid_receptor binding and activation of a heterologous promoter by dexamethasone by the first intron of the human growth_hormone gene .
3124015	0	dexamethasone	41,54	growth_hormone	118,132	dexamethasone	growth hormone	MESH:D003907	2688	Chemical	Gene	potentiates|amod|START_ENTITY growth_hormone-releasing|nsubj|potentiates growth_hormone-releasing|dobj|release release|compound|END_ENTITY	Depending on the time of administration , dexamethasone potentiates or blocks growth_hormone-releasing hormone-induced growth_hormone release in man .
3981636	0	dexamethasone	56,69	growth_hormone	14,28	dexamethasone	growth hormone	MESH:D003907	81668(Tax:10116)	Chemical	Gene	RNA|nmod|START_ENTITY RNA|nsubj|Regulation Regulation|nmod|messenger messenger|amod|END_ENTITY	Regulation of growth_hormone messenger RNA synthesis by dexamethasone and triiodothyronine .
7729788	0	dexamethasone	70,83	growth_hormone	21,35	dexamethasone	growth hormone	MESH:D003907	2688	Chemical	Gene	responses|nmod|START_ENTITY responses|amod|END_ENTITY	Diurnal variation of growth_hormone responses to acutely administered dexamethasone in healthy male volunteers .
7804442	0	dexamethasone	5,18	growth_hormone	82,96	dexamethasone	growth hormone	MESH:D003907	2688	Chemical	Gene	administration|compound|START_ENTITY administration|dep|test test|nmod|assessment assessment|nmod|secretion secretion|amod|END_ENTITY	Oral dexamethasone administration : new pharmacological test for the assessment of growth_hormone secretion .
7858732	0	dexamethasone	59,72	growth_hormone	8,22	dexamethasone	growth hormone	MESH:D003907	2688	Chemical	Gene	Lack|nmod|START_ENTITY Lack|nmod|response response|amod|END_ENTITY	Lack of growth_hormone response to acute administration of dexamethasone in anorexia_nervosa .
8214184	0	dexamethasone	77,90	growth_hormone	17,31	dexamethasone	growth hormone	MESH:D003907	2688	Chemical	Gene	result|amod|START_ENTITY relationship|nmod|result release|dep|relationship release|compound|END_ENTITY	Baclofen-induced growth_hormone release in major depression : relationship to dexamethasone suppression test result .
12359793	0	dexamethasone	16,29	hepatocyte_growth_factor	40,64	dexamethasone	hepatocyte growth factor	MESH:D003907	3082	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|END_ENTITY	Early postnatal dexamethasone decreases hepatocyte_growth_factor in tracheal aspirate fluid from premature infants .
12925150	0	dexamethasone	36,49	hepatocyte_growth_factor	72,96	dexamethasone	hepatocyte growth factor	MESH:D003907	3082	Chemical	Gene	START_ENTITY|acl:relcl|reversed reversed|nmod|END_ENTITY	Gastric restitution is inhibited by dexamethasone , which is reversed by hepatocyte_growth_factor and rebamipide .
3105595	0	dexamethasone	40,53	histidine_decarboxylase	13,36	dexamethasone	histidine decarboxylase	MESH:D003907	15186(Tax:10090)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of histidine_decarboxylase by dexamethasone in mastocytoma P-815 cells .
12594738	0	dexamethasone	32,45	iNOS	60,64	dexamethasone	iNOS	MESH:D003907	4843	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|expression expression|compound|END_ENTITY	Molecular mechanisms underlying dexamethasone inhibition of iNOS expression and activity in C6 glioma cells .
9195984	0	dexamethasone	135,148	inducible_nitric-oxide_synthase	29,60	dexamethasone	inducible nitric-oxide synthase	MESH:D003907	18126(Tax:10090)	Chemical	Gene	cells|nmod|START_ENTITY Mechanisms|dep|cells Mechanisms|nmod|suppression suppression|nmod|expression expression|amod|END_ENTITY	Mechanisms of suppression of inducible_nitric-oxide_synthase -LRB- iNOS -RRB- expression in interferon _ -LRB- IFN -RRB- - gamma-stimulated RAW 264.7 cells by dexamethasone .
17379310	0	dexamethasone	65,78	inducible_nitric_oxide_synthase	25,56	dexamethasone	inducible nitric oxide synthase	MESH:D003907	18126(Tax:10090)	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Regulation of the murine inducible_nitric_oxide_synthase gene by dexamethasone involves a heterogeneous_nuclear_ribonucleoprotein_I -LRB- hnRNPI -RRB- dependent pathway .
9484793	0	dexamethasone	15,28	inducible_nitric_oxide_synthase	32,63	dexamethasone	inducible nitric oxide synthase	MESH:D003907	24599(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Suppression by dexamethasone of inducible_nitric_oxide_synthase protein expression in vivo : a possible role for lipocortin_1 .
10781386	0	dexamethasone	127,140	insulin	76,83	dexamethasone	insulin	MESH:D003907	105613195	Chemical	Gene	sensitivity|xcomp|START_ENTITY sensitivity|nmod|pressure pressure|compound|END_ENTITY	Differential timing for programming of glucose homoeostasis , sensitivity to insulin and blood pressure by in utero exposure to dexamethasone in sheep .
10807673	0	dexamethasone	35,48	insulin	57,64	dexamethasone	insulin	MESH:D003907	3630	Chemical	Gene	resistance|amod|START_ENTITY resistance|compound|END_ENTITY	Troglitazone prevents and reverses dexamethasone induced insulin resistance on glycogen synthesis in 3T3 adipocytes .
15800288	0	dexamethasone	63,76	insulin	11,18	dexamethasone	insulin	MESH:D003907	3630	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Changes Changes|nmod|secretion secretion|compound|END_ENTITY	Changes in insulin secretion and glucose metabolism induced by dexamethasone in lean and obese females .
17356009	0	dexamethasone	21,34	insulin	88,95	dexamethasone	insulin	MESH:D003907	105613195	Chemical	Gene	exposure|nmod|START_ENTITY alters|nsubj|exposure alters|dobj|secretion secretion|compound|END_ENTITY	Maternal exposure to dexamethasone or cortisol in early pregnancy differentially alters insulin secretion and glucose homeostasis in adult male sheep offspring .
19526859	0	dexamethasone	74,87	insulin	14,21	dexamethasone	insulin	MESH:D003907	100009181(Tax:9986)	Chemical	Gene	-RSB-|amod|START_ENTITY using|dobj|-RSB- metabolic_disorders|xcomp|using metabolic_disorders|nsubj|Modelling Modelling|nmod|resistance resistance|compound|END_ENTITY	-LSB- Modelling of insulin resistance and associated metabolic_disorders using dexamethasone -RSB- .
20667567	0	dexamethasone	21,34	insulin	51,58	dexamethasone	insulin	MESH:D003907	483665(Tax:9615)	Chemical	Gene	applications|compound|START_ENTITY Influence|nmod|applications Influence|nmod|hormone hormone|compound|END_ENTITY	Influence of topical dexamethasone applications on insulin , glucose , thyroid hormone and cortisol levels in dogs .
20840879	0	dexamethasone	48,61	insulin	18,25	dexamethasone	insulin	MESH:D003907	3630	Chemical	Gene	induced|nmod|START_ENTITY resistance|acl|induced resistance|compound|END_ENTITY	Berberine reduces insulin resistance induced by dexamethasone in theca cells in vitro .
23521139	0	dexamethasone	77,90	insulin	33,40	dexamethasone	insulin	MESH:D003907	3630	Chemical	Gene	tests|amod|START_ENTITY results|nmod|tests results|compound|END_ENTITY	Seasonal and annual influence on insulin and cortisol results from overnight dexamethasone suppression tests in normal ponies and ponies predisposed to laminitis .
2677680	0	dexamethasone	101,114	insulin	81,88	dexamethasone	insulin	MESH:D003907	3630	Chemical	Gene	decreases|nsubj|START_ENTITY cloned|parataxis|decreases cloned|nmod|brain brain|nmod|models models|nmod|resistance resistance|compound|END_ENTITY	Expression of a glucose transporter gene cloned from brain in cellular models of insulin resistance : dexamethasone decreases transporter mRNA in primary cultured adipocytes .
2837206	0	dexamethasone	38,51	insulin	10,17	dexamethasone	insulin	MESH:D003907	3630	Chemical	Gene	induction|nmod|START_ENTITY Effect|nmod|induction Effect|nmod|END_ENTITY	Effect of insulin on the induction by dexamethasone of glucose-6-phosphohydrolase and translocase activities in cultured hepatoma cells .
7002662	0	dexamethasone	54,67	insulin	10,17	dexamethasone	insulin	MESH:D003907	3630	Chemical	Gene	ingestion|amod|START_ENTITY erythrocytes|nmod|ingestion END_ENTITY|nmod|erythrocytes	Decreased insulin binding of human erythrocytes after dexamethasone or prednisone ingestion .
788430	0	dexamethasone	52,65	insulin	4,11	dexamethasone	insulin	MESH:D003907	3630	Chemical	Gene	test|nmod|START_ENTITY test|nsubj|tolerance tolerance|compound|END_ENTITY	The insulin tolerance test after pre-treatment with dexamethasone .
8436259	0	dexamethasone	10,23	insulin	27,34	dexamethasone	insulin	MESH:D003907	3630	Chemical	Gene	START_ENTITY|nmod|sensitivity sensitivity|compound|END_ENTITY	Effect of dexamethasone on insulin sensitivity , islet amyloid polypeptide and insulin secretion in humans .
8954054	0	dexamethasone	11,24	insulin	87,94	dexamethasone	insulin	MESH:D003907	3630	Chemical	Gene	treatment|compound|START_ENTITY increases|nsubj|treatment increases|dobj|leptin leptin|nmod|changes changes|nmod|sensitivity sensitivity|compound|END_ENTITY	Short-term dexamethasone treatment increases plasma leptin independently of changes in insulin sensitivity in healthy women .
10873033	0	dexamethasone	10,23	insulin-like_growth_factor-1	27,55	dexamethasone	insulin-like growth factor-1	MESH:D003907	100008668(Tax:9986)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of dexamethasone on insulin-like_growth_factor-1 expression in a rabbit model of growth_retardation .
8640952	0	dexamethasone	50,63	insulin-like_growth_factor-I	108,136	dexamethasone	insulin-like growth factor-I	MESH:D003907	3479	Chemical	Gene	activation|amod|START_ENTITY activation|acl|induced induced|nmod|END_ENTITY	Long-term treatment of Swiss 3T3 fibroblasts with dexamethasone attenuates MAP kinase activation induced by insulin-like_growth_factor-I -LRB- IGF-I -RRB- .
8162170	0	dexamethasone	50,63	insulin-like_growth_factor_I	16,44	dexamethasone	insulin-like growth factor I	MESH:D003907	24482(Tax:10116)	Chemical	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of insulin-like_growth_factor_I with dexamethasone on trabecular bone density and mineral metabolism in rats .
1710191	0	dexamethasone	73,86	insulin-like_growth_factor_binding_protein-3	14,58	dexamethasone	insulin-like growth factor binding protein-3	MESH:D003907	3486	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of insulin-like_growth_factor_binding_protein-3 expression by dexamethasone .
1374400	0	dexamethasone	95,108	insulin_receptor	50,66	dexamethasone	insulin receptor	MESH:D003907	3643	Chemical	Gene	expression|amod|START_ENTITY expression|appos|protein protein|compound|END_ENTITY	Regulation of the expression of pp160 , a putative insulin_receptor signal protein , by insulin , dexamethasone , and 1-methyl-3-isobutylxanthine in 3T3-L1 adipocytes .
1782593	0	dexamethasone	68,81	insulin_receptor	16,32	dexamethasone	insulin receptor	MESH:D003907	24954(Tax:10116)	Chemical	Gene	-RSB-|compound|START_ENTITY Alterations|nmod|-RSB- Alterations|nmod|END_ENTITY	-LSB- Alterations in insulin_receptor in injured rats and the effects of dexamethasone and silybin -RSB- .
18401942	0	dexamethasone	11,24	insulin_receptor	28,44	dexamethasone	insulin receptor	MESH:D003907	24954(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of dexamethasone on insulin_receptor in aging .
3446556	0	dexamethasone	10,23	insulin_receptor	60,76	dexamethasone	insulin receptor	MESH:D003907	3643	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|synthesis synthesis|nmod|mRNA mRNA|compound|END_ENTITY	Effect of dexamethasone on the synthesis and degradation of insulin_receptor mRNA in cultured IM-9 cells .
6358216	5	dexamethasone	804,817	insulin_receptor	837,853	dexamethasone	insulin receptor	MESH:D003907	24954(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|up-regulates up-regulates|dep|END_ENTITY	In order to assess the mechanism by which dexamethasone `` up-regulates '' the insulin_receptor , the heavy isotope density-shift technique was used to analyze insulin_receptor turnover in control and dexamethasone-treated hepatocytes .
7712917	0	dexamethasone	33,46	insulin_receptor	77,93	dexamethasone	insulin receptor	MESH:D003907	3643	Chemical	Gene	START_ENTITY|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- The effect of hydrocortisone or dexamethasone on human erythrocyte membrane insulin_receptor -RSB- .
8179619	0	dexamethasone	10,23	insulin_receptor	58,74	dexamethasone	insulin receptor	MESH:D003907	3643	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|chains chains|nmod|END_ENTITY	Effect of dexamethasone on the carbohydrate chains of the insulin_receptor .
8408055	0	dexamethasone	10,23	insulin_receptor	59,75	dexamethasone	insulin receptor	MESH:D003907	3643	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|splicing splicing|nmod|mRNA mRNA|compound|END_ENTITY	Effect of dexamethasone on the alternative splicing of the insulin_receptor mRNA and insulin action in HepG2 hepatoma cells .
8905476	0	dexamethasone	10,23	insulin_receptor	27,43	dexamethasone	insulin receptor	MESH:D003907	3643	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Effect of dexamethasone on insulin_receptor mRNA levels , RNA stability and isotype RNA pattern in U-937 human promonocytic cells .
11421927	0	dexamethasone	96,109	intercellular_adhesion_molecule-1	113,146	dexamethasone	intercellular adhesion molecule-1	MESH:D003907	3383	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|expression expression|amod|END_ENTITY	Expression of adhesion molecules on cord-blood-derived , cultured human mast cells and effect of dexamethasone on intercellular_adhesion_molecule-1 expression on the mast cells treated by phorbol_myristate_acetate .
17294742	0	dexamethasone	11,24	intercellular_adhesion_molecule-1	42,75	dexamethasone	intercellular adhesion molecule-1	MESH:D003907	3383	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of dexamethasone on expression of intercellular_adhesion_molecule-1 in orbital fibroblasts from thyroid_associated_ophthalmopathy -RSB- .
7694584	0	dexamethasone	10,23	intercellular_adhesion_molecule-1	64,97	dexamethasone	intercellular adhesion molecule-1	MESH:D003907	3383	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of dexamethasone , 6-mercaptopurine and cyclosporine_A on intercellular_adhesion_molecule-1 and vascular_cell_adhesion_molecule-1 expression .
7726748	0	dexamethasone	11,24	intercellular_adhesion_molecule-1	28,61	dexamethasone	intercellular adhesion molecule-1	MESH:D003907	3383	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effect of dexamethasone on intercellular_adhesion_molecule-1 expression on cultured bronchial epithelial cells stimulated by inflammatory cytokines -RSB- .
7907090	0	dexamethasone	142,155	intercellular_adhesion_molecule-1	92,125	dexamethasone	intercellular adhesion molecule-1	MESH:D003907	3383	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|induction induction|nmod|END_ENTITY	12-O-tetradecanoylphorbol-13-acetate - and tumor_necrosis_factor_alpha-mediated induction of intercellular_adhesion_molecule-1 is inhibited by dexamethasone .
20442680	0	dexamethasone	11,24	intercellular_adhesion_molecule_1	28,61	dexamethasone	intercellular adhesion molecule 1	MESH:D003907	25464(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effects of dexamethasone on intercellular_adhesion_molecule_1 expression and inflammatory response in necrotizing acute_pancreatitis in rats .
2824488	0	dexamethasone	89,102	interleukin-1	58,71	dexamethasone	interleukin-1	MESH:D003907	3552	Chemical	Gene	induced|nmod|START_ENTITY induced|advcl|END_ENTITY	Transcription from the stromelysin promoter is induced by interleukin-1 and repressed by dexamethasone .
3500955	0	dexamethasone	58,71	interleukin-1	18,31	dexamethasone	interleukin-1	MESH:D003907	3552	Chemical	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	Recombinant human interleukin-1 inhibits the induction by dexamethasone of alkaline phosphatase activity in murine capillary endothelial cells .
10430110	0	dexamethasone	10,23	interleukin-10	87,101	dexamethasone	interleukin-10	MESH:D003907	3586	Chemical	Gene	concentrations|amod|START_ENTITY concentrations|amod|END_ENTITY	Effect of dexamethasone on reactive oxygen species generation by leukocytes and plasma interleukin-10 concentrations : a pharmacodynamic study .
17186732	0	dexamethasone	70,83	interleukin-13	87,101	dexamethasone	interleukin-13	MESH:D003907	116553(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Inhibitory effects of Salvia miltiorrhiza injection coordinated with dexamethasone on interleukin-13 and eotaxin expression in lung of asthmatic rats -RSB- .
19797730	0	dexamethasone	10,23	interleukin-18	34,48	dexamethasone	interleukin-18	MESH:D003907	3606	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	High-dose dexamethasone regulates interleukin-18 and interleukin-18_binding_protein in idiopathic_thrombocytopenic_purpura .
2022738	0	dexamethasone	163,176	interleukin-1_beta	63,81	dexamethasone	interleukin-1 beta	MESH:D003907	3553	Chemical	Gene	cultured|nmod|START_ENTITY cultured|nsubj|modulation modulation|nmod|END_ENTITY	Temperature-dependent modulation of lipopolysaccharide-induced interleukin-1_beta and tumor_necrosis_factor_alpha expression in cultured human astroglial cells by dexamethasone and indomethacin .
7593467	0	dexamethasone	98,111	interleukin-1_beta	41,59	dexamethasone	interleukin-1 beta	MESH:D003907	3553	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|induction induction|nmod|END_ENTITY	Protein synthesis-dependent induction of interleukin-1_beta by lipopolysaccharide is inhibited by dexamethasone via mRNA destabilization in human astroglial cells .
8525083	0	dexamethasone	14,27	interleukin-1_beta	31,49	dexamethasone	interleukin-1 beta	MESH:D003907	281251(Tax:9913)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Inhibition by dexamethasone of interleukin-1_beta and interleukin-6 expression in alveolar macrophages from cows .
8574830	0	dexamethasone	33,46	interleukin-1_beta	129,147	dexamethasone	interleukin-1 beta	MESH:D003907	3553	Chemical	Gene	START_ENTITY|nmod|production production|nmod|tumor_necrosis_factor_alpha tumor_necrosis_factor_alpha|appos|IL-1_beta IL-1_beta|amod|END_ENTITY	Effect of xanthine derivates and dexamethasone on Streptococcus_pneumoniae-stimulated production of tumor_necrosis_factor_alpha , interleukin-1_beta -LRB- IL-1_beta -RRB- , and IL-10 by human leukocytes .
8711133	0	dexamethasone	128,141	interleukin-1_beta	79,97	dexamethasone	interleukin-1 beta	MESH:D003907	3553	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubj|Induction Induction|nmod|A2 A2|nmod|cells cells|amod|END_ENTITY	Induction of both cytosolic phospholipase A2 and prostaglandin_H synthase-2 by interleukin-1_beta in WISH cells in inhibited by dexamethasone .
2687057	0	dexamethasone	10,23	interleukin-2	45,58	dexamethasone	interleukin-2	MESH:D003907	16183(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effect of dexamethasone on the expression of interleukin-2 in a mouse T cell line .
22289995	0	dexamethasone	21,34	interleukin-22	49,63	dexamethasone	interleukin-22	MESH:D003907	50616	Chemical	Gene	START_ENTITY|acl|regulating regulating|dobj|production production|amod|END_ENTITY	Effects of high-dose dexamethasone on regulating interleukin-22 production and correcting Th1 and Th22 polarization in immune_thrombocytopenia .
9208595	0	dexamethasone	11,24	interleukin-2_receptor_alpha	38,66	dexamethasone	interleukin-2 receptor alpha	MESH:D003907	3559	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effect of dexamethasone on the human interleukin-2_receptor_alpha chain gene expression -RSB- .
9626336	0	dexamethasone	85,98	interleukin-4	150,163	dexamethasone	interleukin-4	MESH:D003907	16189(Tax:10090)	Chemical	Gene	interleukin-2|amod|START_ENTITY interleukin-2|appos|END_ENTITY	Adrenal hormone modulation of type 1 and type 2 cytokine production by spleen cells : dexamethasone and dehydroepiandrosterone suppress interleukin-2 , interleukin-4 , and interferon-gamma production in vitro .
1493921	0	dexamethasone	47,60	interleukin-5	14,27	dexamethasone	interleukin-5	MESH:D003907	3567	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|expression expression|amod|END_ENTITY	Inhibition of interleukin-5 gene expression by dexamethasone .
7861551	0	dexamethasone	21,34	interleukin-6	138,151	dexamethasone	interleukin-6	MESH:D003907	3569	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|nmod|END_ENTITY	Inhibitory effect of dexamethasone and progesterone in vitro on proliferation of human renal_cell_carcinomas and effects on expression of interleukin-6 or interleukin-6_receptor .
12371610	0	dexamethasone	28,41	interleukin-6_receptor	82,104	dexamethasone	interleukin-6 receptor	MESH:D003907	3570	Chemical	Gene	generation|compound|START_ENTITY generation|nmod|END_ENTITY	A synthetic corticosteroid , dexamethasone regulates generation of soluble form of interleukin-6_receptor of human lymphocytes , in vitro .
8206512	0	dexamethasone	42,55	interleukin-8	14,27	dexamethasone	interleukin-8	MESH:D003907	3576	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|expression expression|amod|END_ENTITY	Inhibition of interleukin-8 expression by dexamethasone in human cultured airway epithelial cells .
9351511	0	dexamethasone	23,36	interleukin_1beta	40,57	dexamethasone	interleukin 1beta	MESH:D003907	24494(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|amod|END_ENTITY	Differential effect of dexamethasone on interleukin_1beta - and cyclic_AMP-triggered expression of GTP_cyclohydrolase_I in rat renal mesangial cells .
6555065	0	dexamethasone	41,54	kallikrein	23,33	dexamethasone	kallikrein	MESH:D003907	9622	Chemical	Gene	administration|amod|START_ENTITY END_ENTITY|nmod|administration	Increased excretion of kallikrein during dexamethasone administration in normal man on low and normal salt intake .
11068953	0	dexamethasone	42,55	leptin	86,92	dexamethasone	leptin	MESH:D003907	3952	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|variation variation|nmod|levels levels|compound|END_ENTITY	Effect of one morning meal and a bolus of dexamethasone on 24-hour variation of serum leptin levels in humans .
11285459	0	dexamethasone	13,26	leptin	70,76	dexamethasone	leptin	MESH:D003907	3952	Chemical	Gene	loss|compound|START_ENTITY Influence|nmod|loss Influence|nmod|regulation regulation|nmod|levels levels|compound|END_ENTITY	Influence of dexamethasone and weight loss on the regulation of serum leptin levels in obese individuals .
12450621	0	dexamethasone	11,24	leptin	96,102	dexamethasone	leptin	MESH:D003907	100034042(Tax:9796)	Chemical	Gene	Effects|nmod|START_ENTITY glucose|nsubj|Effects glucose|nmod|concentrations concentrations|compound|END_ENTITY	Effects of dexamethasone , glucose infusion , adrenocorticotropin , and propylthiouracil on plasma leptin concentrations in horses .
12739736	0	dexamethasone	25,38	leptin	49,55	dexamethasone	leptin	MESH:D003907	3952	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Effect of small doses of dexamethasone on plasma leptin levels in normal and obese subjects : a dose-response study .
17241522	0	dexamethasone	40,53	leptin	95,101	dexamethasone	leptin	MESH:D003907	25608(Tax:10116)	Chemical	Gene	chronic_heart_failure|nmod|START_ENTITY Improvement|nmod|chronic_heart_failure associated|nsubjpass|Improvement associated|nmod|downregulation downregulation|nmod|END_ENTITY	Improvement of chronic_heart_failure by dexamethasone is not associated with downregulation of leptin in rats .
8954054	0	dexamethasone	11,24	leptin	52,58	dexamethasone	leptin	MESH:D003907	3952	Chemical	Gene	treatment|compound|START_ENTITY increases|nsubj|treatment increases|dobj|END_ENTITY	Short-term dexamethasone treatment increases plasma leptin independently of changes in insulin sensitivity in healthy women .
9013747	0	dexamethasone	85,98	leptin	5,11	dexamethasone	leptin	MESH:D003907	3952	Chemical	Gene	stimulated|nmod|START_ENTITY stimulated|nsubjpass|concentrations concentrations|compound|END_ENTITY	High leptin concentrations in serum of very obese children are further stimulated by dexamethasone .
9329344	0	dexamethasone	37,50	leptin	7,13	dexamethasone	leptin	MESH:D003907	3952	Chemical	Gene	Robust|xcomp|START_ENTITY Robust|dobj|responses responses|compound|END_ENTITY	Robust leptin secretory responses to dexamethasone in obese subjects .
9626154	0	dexamethasone	113,126	leptin	151,157	dexamethasone	leptin	MESH:D003907	3952	Chemical	Gene	vitro|amod|START_ENTITY tissue|nmod|vitro secretion|nmod|tissue leptin|acl|secretion differences|nmod|leptin stimulate|nsubj|differences stimulate|dobj|release release|compound|END_ENTITY	Gender differences in both spontaneous and stimulated leptin secretion by human omental adipose tissue in vitro : dexamethasone and estradiol stimulate leptin release in women , but not in men .
9626154	0	dexamethasone	113,126	leptin	54,60	dexamethasone	leptin	MESH:D003907	3952	Chemical	Gene	vitro|amod|START_ENTITY tissue|nmod|vitro secretion|nmod|tissue END_ENTITY|acl|secretion	Gender differences in both spontaneous and stimulated leptin secretion by human omental adipose tissue in vitro : dexamethasone and estradiol stimulate leptin release in women , but not in men .
9504395	0	dexamethasone	53,66	lipocortin-1	12,24	dexamethasone	lipocortin-1	MESH:D003907	16952(Tax:10090)	Chemical	Gene	action|nmod|START_ENTITY END_ENTITY|nmod|action	The role of lipocortin-1 in the inhibitory action of dexamethasone on eosinophil trafficking in cutaneous inflammatory reactions in the mouse .
10594555	0	dexamethasone	25,38	lipocortin_1	131,143	dexamethasone	lipocortin 1	MESH:D003907	301	Chemical	Gene	effect|nmod|START_ENTITY mediated|nsubjpass|effect mediated|nmod|END_ENTITY	The inhibitory effect of dexamethasone on lymphocyte adhesion molecule expression and intercellular aggregation is not mediated by lipocortin_1 .
18475502	0	dexamethasone	39,52	lipocortin_1	23,35	dexamethasone	lipocortin 1	MESH:D003907	301	Chemical	Gene	suppression|amod|START_ENTITY END_ENTITY|nmod|suppression	Lack of involvement of lipocortin_1 in dexamethasone suppression of IL-1 release .
7566434	0	dexamethasone	78,91	lipocortin_1	24,36	dexamethasone	lipocortin 1	MESH:D003907	25380(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY reverses|dobj|effects reverses|nsubj|Immunoneutralization Immunoneutralization|nmod|END_ENTITY	Immunoneutralization of lipocortin_1 reverses the acute inhibitory effects of dexamethasone on the hypothalamo-pituitary-adrenocortical responses to cytokines in the rat in vitro and in vivo .
8428215	0	dexamethasone	38,51	lipocortin_1	119,131	dexamethasone	lipocortin 1	MESH:D003907	25380(Tax:10116)	Chemical	Gene	action|nmod|START_ENTITY reversed|nsubjpass|action reversed|nmod|END_ENTITY	The local anti-inflammatory action of dexamethasone in the rat carrageenin oedema model is reversed by an antiserum to lipocortin_1 .
9202235	0	dexamethasone	85,98	lipocortin_1	37,49	dexamethasone	lipocortin 1	MESH:D003907	25380(Tax:10116)	Chemical	Gene	actions|nmod|START_ENTITY reverses|dobj|actions reverses|nsubj|oligodeoxynucleotide oligodeoxynucleotide|nmod|END_ENTITY	An antisense oligodeoxynucleotide to lipocortin_1 reverses the inhibitory actions of dexamethasone on the release of adrenocorticotropin from rat pituitary tissue in vitro .
9484793	0	dexamethasone	15,28	lipocortin_1	112,124	dexamethasone	lipocortin 1	MESH:D003907	25380(Tax:10116)	Chemical	Gene	Suppression|nmod|START_ENTITY Suppression|dep|role role|nmod|END_ENTITY	Suppression by dexamethasone of inducible_nitric_oxide_synthase protein expression in vivo : a possible role for lipocortin_1 .
351125	0	dexamethasone	11,24	luteinizing_hormone_releasing_hormone	103,140	dexamethasone	luteinizing hormone releasing hormone	MESH:D003907	2796	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of dexamethasone on the responses of luteinizing hormone and testosterone to two injections of luteinizing_hormone_releasing_hormone in young postpubertal bulls .
8157714	0	dexamethasone	36,49	lysozyme	14,22	dexamethasone	lysozyme	MESH:D003907	4069	Chemical	Gene	synthesis|nmod|START_ENTITY synthesis|amod|END_ENTITY	Inhibition of lysozyme synthesis by dexamethasone in human mononuclear leukocytes : an index of glucocorticoid sensitivity .
23611130	0	dexamethasone	91,104	mTOR	136,140	dexamethasone	mTOR	MESH:D003907	21977(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|suppression suppression|compound|END_ENTITY	Rapamycin sensitizes glucocorticoid resistant acute_lymphoblastic_leukemia CEM-C1 cells to dexamethasone induced apoptosis through both mTOR suppression and up-regulation and activation of glucocorticoid_receptor .
16878025	0	dexamethasone	11,24	macrophage_migration_inhibitory_factor	28,66	dexamethasone	macrophage migration inhibitory factor	MESH:D003907	17319(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|production production|compound|END_ENTITY	Effects of dexamethasone on macrophage_migration_inhibitory_factor production in sepsis .
14515793	0	dexamethasone	15,28	matrix_metalloproteinase-9	62,88	dexamethasone	matrix metalloproteinase-9	MESH:D003907	17395(Tax:10090)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	-LSB- Inhibition of dexamethasone , indomethacin and resveratrol on matrix_metalloproteinase-9 and the mechanism of inhibition -RSB- .
21941784	0	dexamethasone	12,25	matrix_metalloproteinase-9	56,82	dexamethasone	matrix metalloproteinase-9	MESH:D003907	81687(Tax:10116)	Chemical	Gene	pretreatment|amod|START_ENTITY Effects|nmod|pretreatment Effects|nmod|END_ENTITY	-LSB- Effects of dexamethasone pretreatment on expression of matrix_metalloproteinase-9 in rats with acute_lung_injury induced by phosgene -RSB- .
9855321	0	dexamethasone	20,33	mdr1	67,71	dexamethasone	mdr1	MESH:D003907	5243	Chemical	Gene	START_ENTITY|appos|modulator modulator|appos|END_ENTITY	Pharmacokinetics of dexamethasone and valspodar , a P-glycoprotein -LRB- mdr1 -RRB- modulator : implications for coadministration .
22954907	0	dexamethasone	52,65	miR-155	69,76	dexamethasone	miR-155	MESH:D003907	406947	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Role of miR-155 in myasthenia_gravis and effect of dexamethasone on miR-155 -RSB- .
22954907	0	dexamethasone	52,65	miR-155	9,16	dexamethasone	miR-155	MESH:D003907	406947	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	-LSB- Role of miR-155 in myasthenia_gravis and effect of dexamethasone on miR-155 -RSB- .
19698107	0	dexamethasone	46,59	midkine	22,29	dexamethasone	midkine	MESH:D003907	81517(Tax:10116)	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	The angiogenic factor midkine is regulated by dexamethasone and retinoic_acid during alveolarization and in alveolar epithelial cells .
15543937	0	dexamethasone	10,23	moesin	27,33	dexamethasone	moesin	MESH:D003907	100338273(Tax:9986)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of dexamethasone on moesin gene expression in rabbit bone marrow stromal cells .
12172258	0	dexamethasone	11,24	mucin	28,33	dexamethasone	mucin	MESH:D003907	100508689	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of dexamethasone on mucin gene expression in cultured human nasal epithelial cells .
15361359	0	dexamethasone	11,24	mucin	35,40	dexamethasone	mucin	MESH:D003907	100508689	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|production production|compound|END_ENTITY	Effects of dexamethasone on Muc5ac mucin production by primary airway goblet cells .
15362678	0	dexamethasone	12,25	mucin	29,34	dexamethasone	mucin	MESH:D003907	100508689	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	-LSB- Effects of dexamethasone on mucin gene expression in human nasal_polyps -RSB- .
15503858	0	dexamethasone	93,106	mucin	64,69	dexamethasone	mucin	MESH:D003907	65202(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY line|dep|effects line|nmod|model model|acl|studying studying|dobj|expression expression|compound|END_ENTITY	The DHE cell line as a model for studying rat gastro-intestinal mucin expression : effects of dexamethasone .
17600317	0	dexamethasone	10,23	mucin	52,57	dexamethasone	mucin	MESH:D003907	100508689	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of dexamethasone and ACC on bacteria-induced mucin expression in human airway mucosa .
11874683	0	dexamethasone	10,23	myelin_basic_protein	71,91	dexamethasone	myelin basic protein	MESH:D003907	100344447(Tax:9986)	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of dexamethasone by local treatment on cerebral_edema and serum myelin_basic_protein after brain_injury in rabbits .
1717183	0	dexamethasone	11,24	myelin_basic_protein	46,66	dexamethasone	myelin basic protein	MESH:D003907	24547(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|proteolipid_protein proteolipid_protein|compound|END_ENTITY	Effects of dexamethasone on the expression of myelin_basic_protein , proteolipid_protein , and glial_fibrillary_acidic_protein genes in developing rat brain .
20034887	0	dexamethasone	22,35	myeloid_differentiation_factor_88	39,72	dexamethasone	myeloid differentiation factor 88	MESH:D003907	17874(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expressions expressions|amod|END_ENTITY	-LSB- Inhibitory effect of dexamethasone on myeloid_differentiation_factor_88 and tumor_necrosis_factor-alpha expressions in mouse peritoneal macrophages -RSB- .
25450062	0	dexamethasone	64,77	myocilin	44,52	dexamethasone	myocilin	MESH:D003907	4653	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	NFATc1 activity regulates the expression of myocilin induced by dexamethasone .
6878753	0	dexamethasone	74,87	neurotensin	14,25	dexamethasone	neurotensin	MESH:D003907	4922	Chemical	Gene	effect|nmod|START_ENTITY Regulation|dep|effect Regulation|nmod|secretion secretion|compound|END_ENTITY	Regulation of neurotensin secretion in a mammalian C cell line : effect of dexamethasone .
7111768	0	dexamethasone	89,102	neurotensin	23,34	dexamethasone	neurotensin	MESH:D003907	299757(Tax:10116)	Chemical	Gene	modulation|nmod|START_ENTITY Content|dep|modulation Content|nmod|END_ENTITY	Content and release of neurotensin in PC12 pheochromocytoma cell cultures : modulation by dexamethasone and nerve_growth_factor .
7750477	0	dexamethasone	11,24	neurotensin	42,53	dexamethasone	neurotensin	MESH:D003907	299757(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|production production|compound|END_ENTITY	Effects of dexamethasone and forskolin on neurotensin production in rat hypothalamic cultures .
1325811	0	dexamethasone	104,117	neutral_endopeptidase	150,171	dexamethasone	neutral endopeptidase	MESH:D003907	4311	Chemical	Gene	accelerates|nsubj|START_ENTITY accelerates|advcl|stimulating stimulating|dobj|synthesis synthesis|amod|END_ENTITY	Neutral_endopeptidase of a human airway epithelial cell line recovers after hypochlorous_acid exposure : dexamethasone accelerates this by stimulating neutral_endopeptidase mRNA synthesis .
15870909	0	dexamethasone	114,127	neutral_endopeptidase	37,58	dexamethasone	neutral endopeptidase	MESH:D003907	4311	Chemical	Gene	lymphocytes|nmod|START_ENTITY lymphocytes|nsubj|down-regulation down-regulation|nmod|END_ENTITY	Receptor-mediated down-regulation of neutral_endopeptidase -LRB- NEP ; EC 3.4.24.11 ; CD10 -RRB- on immature B lymphocytes by dexamethasone .
8587663	0	dexamethasone	10,23	neutral_endopeptidase	66,87	dexamethasone	neutral endopeptidase	MESH:D003907	24590(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY Effect|nmod|treatment Effect|nmod|distribution distribution|nmod|activity activity|amod|END_ENTITY	Effect of dexamethasone treatment on the regional distribution of neutral_endopeptidase activity in the rat trachea .
9652398	0	dexamethasone	10,23	nuclear_factor-kappaB	64,85	dexamethasone	nuclear factor-kappaB	MESH:D003907	4790	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|END_ENTITY	Effect of dexamethasone on interleukin-1beta - -LRB- IL-1beta -RRB- - induced nuclear_factor-kappaB -LRB- NF-kappaB -RRB- and kappaB-dependent transcription in epithelial cells .
3382666	0	dexamethasone	10,23	ornithine_decarboxylase	58,81	dexamethasone	ornithine decarboxylase	MESH:D003907	24609(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|nmod|END_ENTITY	Effect of dexamethasone on the activity and expression of ornithine_decarboxylase in rat liver and thymus .
25523578	0	dexamethasone	11,24	osteopontin	28,39	dexamethasone	osteopontin	MESH:D003907	20750(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	-LSB- Effect of dexamethasone on osteopontin expression in the lung tissue of asthmatic mice -RSB- .
1328351	0	dexamethasone	21,34	oxytocin	42,50	dexamethasone	oxytocin	MESH:D003907	5020	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|response response|compound|END_ENTITY	Inhibitory effect of dexamethasone on the oxytocin response to insulin-induced hypoglycemia in normal men .
22570346	0	dexamethasone	54,67	p-glycoprotein	27,41	dexamethasone	p-glycoprotein	MESH:D003907	5243	Chemical	Gene	elevated|nmod|START_ENTITY elevated|nsubj|Expression Expression|nmod|END_ENTITY	Expression and activity of p-glycoprotein elevated by dexamethasone in cultured retinal pigment epithelium involve glucocorticoid_receptor and pregnane_X_receptor .
11295047	0	dexamethasone	23,36	p21WAF1/CIP1	86,98	dexamethasone	p21WAF1/CIP1	MESH:D003907	1026	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|nmod|END_ENTITY	Synergistic effects of dexamethasone and genistein on the expression of Cdk inhibitor p21WAF1/CIP1 in human hepatocellular and colorectal_carcinoma cells .
11961339	0	dexamethasone	111,124	peptide_transporter_1	32,53	dexamethasone	peptide transporter 1	MESH:D003907	117261(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of lipopolysaccharide on peptide_transporter_1 expression in rat small intestine and its attenuation by dexamethasone .
17335662	0	dexamethasone	10,23	peroxisome_proliferator_activated_receptor-gamma	27,75	dexamethasone	peroxisome proliferator activated receptor-gamma	MESH:D003907	5468	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effect of dexamethasone on peroxisome_proliferator_activated_receptor-gamma mRNA expression in 3T3-L1 adipocytes with the human recombinant adiponectin .
15166231	0	dexamethasone	26,39	phosphoenolpyruvate_carboxykinase	79,112	dexamethasone	phosphoenolpyruvate carboxykinase	MESH:D003907	362282(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	The synergistic effect of dexamethasone and all-trans-retinoic_acid on hepatic phosphoenolpyruvate_carboxykinase gene expression involves the coactivator p300 .
1710984	0	dexamethasone	38,51	phosphoenolpyruvate_carboxykinase	96,129	dexamethasone	phosphoenolpyruvate carboxykinase	MESH:D003907	362282(Tax:10116)	Chemical	Gene	action|nmod|START_ENTITY Mechanism|nmod|action Mechanism|nmod|activation activation|nmod|gene gene|amod|END_ENTITY	Mechanism of the permissive action of dexamethasone on the glucagon-dependent activation of the phosphoenolpyruvate_carboxykinase gene in cultured rat hepatocytes .
3947691	0	dexamethasone	14,27	phosphoenolpyruvate_carboxykinase	114,147	dexamethasone	phosphoenolpyruvate carboxykinase	MESH:D003907	362282(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY induced|nsubj|effect induced|nmod|levels levels|nmod|END_ENTITY	The effect of dexamethasone and surgically induced intrauterine_growth_retardation on renal and hepatic levels of phosphoenolpyruvate_carboxykinase in the rat .
6822414	0	dexamethasone	36,49	phosphoenolpyruvate_carboxykinase	71,104	dexamethasone	phosphoenolpyruvate carboxykinase	MESH:D003907	18534(Tax:10090)	Chemical	Gene	induction|amod|START_ENTITY Influence|nmod|induction Influence|nmod|END_ENTITY	Influence of endotoxin treatment on dexamethasone induction of hepatic phosphoenolpyruvate_carboxykinase .
7826355	0	dexamethasone	105,118	phosphoenolpyruvate_carboxykinase	18,51	dexamethasone	phosphoenolpyruvate carboxykinase	MESH:D003907	5106	Chemical	Gene	effects|nmod|START_ENTITY Expression|dep|effects Expression|nmod|gene gene|amod|END_ENTITY	Expression of the phosphoenolpyruvate_carboxykinase gene in 3T3-F442A adipose cells : opposite effects of dexamethasone and isoprenaline on transcription .
1374400	0	dexamethasone	95,108	pp160	32,37	dexamethasone	pp160	MESH:D003907	8471	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Regulation of the expression of pp160 , a putative insulin_receptor signal protein , by insulin , dexamethasone , and 1-methyl-3-isobutylxanthine in 3T3-L1 adipocytes .
111552	0	dexamethasone	10,23	prolactin	27,36	dexamethasone	prolactin	MESH:D003907	5617	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of dexamethasone on prolactin secretion in late pregnancy .
3497800	0	dexamethasone	29,42	prolactin	67,76	dexamethasone	prolactin	MESH:D003907	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Effects of acute and chronic dexamethasone treatment on stimulated prolactin secretion in the rat .
6261178	1	dexamethasone	108,121	prolactin	154,163	dexamethasone	prolactin	MESH:D003907	24683(Tax:10116)	Chemical	Gene	vasopressin|compound|START_ENTITY study|nmod|vasopressin study|nmod|END_ENTITY	A comparative study on the effects of dexamethasone , lysine vasopressin and ACTH on prolactin secretion by the rat pituitary gland in vitro .
6354518	0	dexamethasone	126,139	prolactin	41,50	dexamethasone	prolactin	MESH:D003907	5617	Chemical	Gene	altered|nmod|START_ENTITY releasing|parataxis|altered releasing|dobj|release release|compound|END_ENTITY	Gonadotrophin releasing hormone provokes prolactin release in hypergonadotrophic_hypogonadal_women : a response not altered by dexamethasone .
7081489	0	dexamethasone	10,23	prolactin	34,43	dexamethasone	prolactin	MESH:D003907	5617	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of dexamethasone on plasma prolactin and cortisol levels in psychiatric patients .
7371016	0	dexamethasone	38,51	prolactin	90,99	dexamethasone	prolactin	MESH:D003907	24683(Tax:10116)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|rats rats|nmod|presence presence|nmod|levels levels|compound|END_ENTITY	Inhibition of mammary_tumor growth by dexamethasone in rats in the presence of high serum prolactin levels .
7422069	1	dexamethasone	164,177	prolactin	193,202	dexamethasone	prolactin	MESH:D003907	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	Inhibition by dexamethasone of vip-induced prolactin release .
402375	0	dexamethasone	10,23	prolactin_and_TSH	27,44	dexamethasone	prolactin and TSH	MESH:D003907	5617	Chemical	Gene	START_ENTITY|nmod|responses responses|amod|END_ENTITY	Effect of dexamethasone on prolactin_and_TSH responses to TRH and metoclopramide in man .
10520135	0	dexamethasone	19,32	prolactin_receptor	70,88	dexamethasone	prolactin receptor	MESH:D003907	443020(Tax:9940)	Chemical	Gene	treatment|compound|START_ENTITY treatment|nmod|END_ENTITY	Effect of maternal dexamethasone treatment and ambient temperature on prolactin_receptor abundance in Brown adipose and hepatic tissue in the foetus and new-born lamb .
12415599	0	dexamethasone	78,91	proliferating_cell_nuclear_antigen	24,58	dexamethasone	proliferating cell nuclear antigen	MESH:D003907	25737(Tax:10116)	Chemical	Gene	inhibition|amod|START_ENTITY associated|nmod|inhibition associated|nsubjpass|expression expression|nmod|END_ENTITY	Decreased expression of proliferating_cell_nuclear_antigen is associated with dexamethasone inhibition of the proliferation of rat tendon fibroblasts .
1360848	0	dexamethasone	26,39	proliferating_cell_nuclear_antigen	51,85	dexamethasone	proliferating cell nuclear antigen	MESH:D003907	5111	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Influence of preoperative dexamethasone therapy on proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- expression in comparison to other parameters in meningiomas .
1717183	0	dexamethasone	11,24	proteolipid_protein	68,87	dexamethasone	proteolipid protein	MESH:D003907	24943(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of dexamethasone on the expression of myelin_basic_protein , proteolipid_protein , and glial_fibrillary_acidic_protein genes in developing rat brain .
17448315	0	dexamethasone	10,23	pulmonary_surfactant_protein_D	42,72	dexamethasone	pulmonary surfactant protein D	MESH:D003907	25350(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of dexamethasone on the content of pulmonary_surfactant_protein_D in young rats with acute_lung_injury induced by lipopolysaccharide .
2875992	0	dexamethasone	88,101	somatostatin	18,30	dexamethasone	somatostatin	MESH:D003907	6750	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|production production|compound|END_ENTITY	The regulation of somatostatin production in human medullary_thyroid_carcinoma cells by dexamethasone .
18187254	0	dexamethasone	11,24	stanniocalcin-1	47,62	dexamethasone	stanniocalcin-1	MESH:D003907	81801(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|amod|END_ENTITY	Effects of dexamethasone and dibutyryl_cAMP on stanniocalcin-1 mRNA expression in rat primary Sertoli and Leydig cells .
17526944	0	dexamethasone	75,88	steroidogenic_acute_regulatory_protein	22,60	dexamethasone	steroidogenic acute regulatory protein	MESH:D003907	25557(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	In vivo inhibition of steroidogenic_acute_regulatory_protein expression by dexamethasone parallels induction of the negative transcription factor DAX-1 .
12167565	0	dexamethasone	11,24	sulfotransferase	73,89	dexamethasone	sulfotransferase	MESH:D003907	6817	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Effects of dexamethasone on aryl -LRB- SULT1A1 -RRB- - and hydroxysteroid -LRB- SULT2A1 -RRB- - sulfotransferase gene expression in primary cultured human hepatocytes .
7603779	0	dexamethasone	115,128	thyrotropin_releasing_hormone	80,109	dexamethasone	thyrotropin releasing hormone	MESH:D003907	25569(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY END_ENTITY|nmod|treatment	Positive regulation of pulmonary antioxidant enzyme gene expression by prenatal thyrotropin_releasing_hormone plus dexamethasone treatment in premature rats exposed to hyperoxia .
15710351	0	dexamethasone	44,57	tristetraprolin	14,29	dexamethasone	tristetraprolin	MESH:D003907	7538	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|expression expression|compound|END_ENTITY	Inhibition of tristetraprolin expression by dexamethasone in activated macrophages .
11950023	0	dexamethasone	106,119	tumor_necrosis_factor	13,34	dexamethasone	tumor necrosis factor	MESH:D003907	7124	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Reduction Reduction|nmod|END_ENTITY	Reduction of tumor_necrosis_factor induced nuclear_factor-kappaB nuclear translocation and DNA binding by dexamethasone in human osteoarthritic synovial tissue explants .
1424636	0	dexamethasone	102,115	tumor_necrosis_factor	13,34	dexamethasone	tumor necrosis factor	MESH:D003907	100033834(Tax:9796)	Chemical	Gene	effect|nmod|START_ENTITY Secretion|dep|effect Secretion|nmod|END_ENTITY	Secretion of tumor_necrosis_factor by endotoxin-treated equine mammary exudate macrophages : effect of dexamethasone and pentoxifylline .
2242421	0	dexamethasone	69,82	tumor_necrosis_factor	36,57	dexamethasone	tumor necrosis factor	MESH:D003907	7124	Chemical	Gene	release|nmod|START_ENTITY release|compound|END_ENTITY	Inhibition of interleukin-2-induced tumor_necrosis_factor release by dexamethasone : prevention of an acquired neutrophil chemotaxis defect and differential suppression of interleukin-2-associated side effects .
7720092	0	dexamethasone	27,40	tumor_necrosis_factor	44,65	dexamethasone	tumor necrosis factor	MESH:D003907	7124	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	The upregulating effect of dexamethasone on tumor_necrosis_factor production is mediated by a nitric_oxide-producing cytochrome P450 .
9035763	0	dexamethasone	15,28	tumor_necrosis_factor	92,113	dexamethasone	tumor necrosis factor	MESH:D003907	7124	Chemical	Gene	dose|amod|START_ENTITY effect|nmod|dose -LSB-|dobj|effect -LSB-|nmod|production production|nmod|END_ENTITY	-LSB- The effect of dexamethasone dose and cell population composition on in vitro production of tumor_necrosis_factor and interleukin-6 by mononuclear cells in peripheral blood of man -RSB- .
10541330	0	dexamethasone	10,23	tumor_necrosis_factor-alpha	35,62	dexamethasone	tumor necrosis factor-alpha	MESH:D003907	7124	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Antenatal dexamethasone suppresses tumor_necrosis_factor-alpha expression in hypoplastic lung in nitrofen-induced diaphragmatic_hernia in rats .
10825382	0	dexamethasone	153,166	tumor_necrosis_factor-alpha	110,137	dexamethasone	tumor necrosis factor-alpha	MESH:D003907	7124	Chemical	Gene	modulation|nmod|START_ENTITY regulation|dep|modulation regulation|nmod|expression expression|nmod|fibroblasts fibroblasts|nmod|END_ENTITY	Post-transcriptional regulation of bradykinin_B1_and_B2_receptor gene expression in human lung fibroblasts by tumor_necrosis_factor-alpha : modulation by dexamethasone .
22020607	0	dexamethasone	115,128	tumor_necrosis_factor-alpha	50,77	dexamethasone	tumor necrosis factor-alpha	MESH:D003907	7124	Chemical	Gene	administration|nmod|START_ENTITY administration|nmod|inhibitor inhibitor|amod|END_ENTITY	Epidural administration of spinal nerves with the tumor_necrosis_factor-alpha inhibitor , etanercept , compared with dexamethasone for treatment of sciatica in patients with lumbar_spinal_stenosis : a prospective randomized study .
8495362	0	dexamethasone	87,100	tumor_necrosis_factor-alpha	15,42	dexamethasone	tumor necrosis factor-alpha	MESH:D003907	7124	Chemical	Gene	Stimulation|nmod|START_ENTITY Stimulation|nmod|production production|amod|END_ENTITY	Stimulation of tumor_necrosis_factor-alpha production by mycoplasmas and inhibition by dexamethasone in cultured astrocytes .
10072898	0	dexamethasone	11,24	tumor_necrosis_factor_alpha	85,112	dexamethasone	tumor necrosis factor alpha	MESH:D003907	7124	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Effects of dexamethasone , ibuprofen , and ligustrazini on lipopolysaccharides-induced tumor_necrosis_factor_alpha production .
10336562	0	dexamethasone	88,101	tumor_necrosis_factor_alpha	44,71	dexamethasone	tumor necrosis factor alpha	MESH:D003907	280943(Tax:9913)	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|Induction Induction|nmod|expression expression|nmod|END_ENTITY	Induction of stromelysin gene expression by tumor_necrosis_factor_alpha is inhibited by dexamethasone , salicylate , and N-acetylcysteine in synovial fibroblasts .
8574830	0	dexamethasone	33,46	tumor_necrosis_factor_alpha	100,127	dexamethasone	tumor necrosis factor alpha	MESH:D003907	7124	Chemical	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	Effect of xanthine derivates and dexamethasone on Streptococcus_pneumoniae-stimulated production of tumor_necrosis_factor_alpha , interleukin-1_beta -LRB- IL-1_beta -RRB- , and IL-10 by human leukocytes .
11490095	0	dexamethasone	155,168	tyrosine_aminotransferase	66,91	dexamethasone	tyrosine aminotransferase	MESH:D003907	24813(Tax:10116)	Chemical	Gene	changes|amod|START_ENTITY changes|amod|END_ENTITY	The responses of rat liver glucocorticoid receptors and genes for tyrosine_aminotransferase , alpha-2-macroglobulin and gamma-fibrinogen to adrenalectomy - , dexamethasone - and inflammation-induced changes in the levels of glucocorticoids and proinflammatory cytokines .
1676968	0	dexamethasone	11,24	tyrosine_aminotransferase	37,62	dexamethasone	tyrosine aminotransferase	MESH:D003907	24813(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|amod|END_ENTITY	Effects of dexamethasone and cAMP on tyrosine_aminotransferase expression in cultured fetal rat hepatocytes .
2899655	0	dexamethasone	90,103	tyrosine_aminotransferase	121,146	dexamethasone	tyrosine aminotransferase	MESH:D003907	24813(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|induction induction|nmod|END_ENTITY	Inverse correlation between dexamethasone_21-mesylate agonist activity and sensitivity to dexamethasone for induction of tyrosine_aminotransferase in rat hepatoma cells .
8975639	0	dexamethasone	89,102	tyrosine_aminotransferase	42,67	dexamethasone	tyrosine aminotransferase	MESH:D003907	24813(Tax:10116)	Chemical	Gene	affects|nmod|START_ENTITY affects|dobj|activity activity|nmod|END_ENTITY	Cadmium affects the activity of rat liver tyrosine_aminotransferase and its induction by dexamethasone .
18544592	0	dexamethasone	24,37	u-PA	102,106	dexamethasone	u-PA	MESH:D003907	5328	Chemical	Gene	Effects|nmod|START_ENTITY Effects|dep|role role|nmod|END_ENTITY	Effects of rhG-CSF plus dexamethasone on hemostatic parameters in healthy granulocyte donors : role of u-PA and nitric_oxide .
3462000	0	dexamethasone	83,96	xanthine_dehydrogenase	48,70	dexamethasone	xanthine dehydrogenase	MESH:D003907	396025(Tax:9031)	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Activation of hepatic and inactivation of renal xanthine_dehydrogenase activity by dexamethasone during the prenatal period in chick eggs .
15380375	0	dexanabinol	16,27	nuclear_factor-kappa_B	51,73	dexanabinol	nuclear factor-kappa B	MESH:C062018	4790	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	The cannabinoid dexanabinol is an inhibitor of the nuclear_factor-kappa_B -LRB- NF-kappa_B -RRB- .
15530877	0	dexefaroxan	96,107	NGF	35,38	dexefaroxan	NGF	MESH:C451723	310738(Tax:10116)	Chemical	Gene	brain|nmod|START_ENTITY END_ENTITY|nmod|brain	In vivo upregulation of endogenous NGF in the rat brain by the alpha2-adrenoreceptor antagonist dexefaroxan : potential role in the protection of the basalocortical cholinergic system during neurodegeneration .
8882592	0	dexfenfluramine	10,25	CRF	63,66	dexfenfluramine	CRF	MESH:D020372	81648(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Effect of dexfenfluramine on the transcriptional activation of CRF and its type 1 receptor within the paraventricular nucleus of the rat hypothalamus .
9825834	0	dexfenfluramine	14,29	CYP2D6	92,98	dexfenfluramine	CYP2D6	MESH:D020372	1565	Chemical	Gene	Metabolism|nmod|START_ENTITY Metabolism|dep|role role|nmod|END_ENTITY	Metabolism of dexfenfluramine in human liver microsomes and by recombinant enzymes : role of CYP2D6 and 1A2 .
12576128	0	dexfenfluramine	37,52	Fos	74,77	dexfenfluramine	Fos	MESH:D020372	14281(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|acl|END_ENTITY	Effect of repeated administration of dexfenfluramine on feeding and brain Fos in mice .
8864481	0	dexfenfluramine	18,33	Fos	37,40	dexfenfluramine	Fos	MESH:D020372	314322(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of chronic dexfenfluramine on Fos in rat brain .
15743365	0	dexloxiglumide	28,42	CCK-1	10,15	dexloxiglumide	CCK-1	MESH:C103490	56477	Chemical	Gene	Effect|amod|START_ENTITY Effect|nmod|END_ENTITY	Effect of CCK-1 antagonist , dexloxiglumide , in female patients with irritable_bowel_syndrome : a pharmacodynamic and pharmacogenomic study .
9403804	0	dexloxiglumide	43,57	CCK-A_receptor	16,30	dexloxiglumide	CCK-A receptor	MESH:C103490	24889(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Effect of a new CCK-A_receptor antagonist , dexloxiglumide , on the exocrine pancreas in the rat .
16163898	0	dexloxiglumide	72,86	CCK1	46,50	dexloxiglumide	CCK1	MESH:C103490	56477	Chemical	Gene	influenced|advmod|START_ENTITY influenced|nsubjpass|pharmacokinetics pharmacokinetics|nmod|antagonist antagonist|compound|END_ENTITY	The single-dose pharmacokinetics of the novel CCK1 receptor antagonist , dexloxiglumide , are not influenced by age and gender .
16484960	0	dexloxiglumide	26,40	CCK1	0,4	dexloxiglumide	CCK1	MESH:C103490	56477	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	CCK1 receptor antagonist , dexloxiglumide : effects on human isolated_gallbladder .
22933299	0	dexmedetomidine	24,39	BMP-7	95,100	dexmedetomidine	BMP-7	MESH:D020927	85272(Tax:10116)	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|END_ENTITY	a2-Adrenoceptor agonist dexmedetomidine protects septic acute_kidney_injury through increasing BMP-7 and inhibiting HDAC2 and HDAC5 .
12749994	0	dexmedetomidine	15,30	Fos	48,51	dexmedetomidine	Fos	MESH:D020927	314322(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|compound|END_ENTITY	The effects of dexmedetomidine and halothane on Fos expression in the spinal dorsal horn using a rat postoperative_pain model .
23042227	0	dexmedetomidine	54,69	dopamine_b-hydroxylase_knockout	73,104	dexmedetomidine	dopamine b-hydroxylase knockout	MESH:D020927	13166(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Hypnotic_hypersensitivity to volatile anesthetics and dexmedetomidine in dopamine_b-hydroxylase_knockout mice .
18311185	0	dexmedetomidine	43,58	epidermal_growth_factor	62,85	dexmedetomidine	epidermal growth factor	MESH:D020927	1950	Chemical	Gene	START_ENTITY|nmod|receptors receptors|compound|END_ENTITY	Signalling pathways for transactivation by dexmedetomidine of epidermal_growth_factor receptors in astrocytes and its paracrine effect on neurons .
21241763	0	dexmedetomidine	11,26	glial_cell_line-derived_neurotrophic_factor	45,88	dexmedetomidine	glial cell line-derived neurotrophic factor	MESH:D020927	25453(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|release release|nmod|END_ENTITY	Effects of dexmedetomidine on the release of glial_cell_line-derived_neurotrophic_factor from rat astrocyte cells .
26896779	0	dexmedetomidine	10,25	interleukin-6	86,99	dexmedetomidine	interleukin-6	MESH:D020927	24498(Tax:10116)	Chemical	Gene	stress|amod|START_ENTITY Effect|nmod|stress Effect|dep|role role|nmod|factor-a factor-a|compound|END_ENTITY	Effect of dexmedetomidine and cold stress in a rat model of neuropathic_pain : role of interleukin-6 and tumor necrosis factor-a .
26770320	7	dexmedetomidine	1117,1132	rat	1239,1242	dexmedetomidine	Bad	MESH:D020927	64639(Tax:10116)	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|nmod|END_ENTITY	Moreover , dexmedetomidine significantly inhibited these TNF-a , IL-1b , MDA , SOD and caspase-3 activities in isoflurane-induced aging rat .
8720592	0	dexniguldipine	57,71	P-glycoprotein	88,102	dexniguldipine	P-glycoprotein	MESH:C054074	5243	Chemical	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Interaction of cytostatics and chemosensitizers with the dexniguldipine binding site on P-glycoprotein .
8024952	0	dexrazoxane	40,51	dihydropyrimidine_amidohydrolase	69,101	dexrazoxane	dihydropyrimidine amidohydrolase	MESH:D011929	1807	Chemical	Gene	hydrolysis|nmod|START_ENTITY hydrolysis|nmod|END_ENTITY	Stereoselective hydrolysis of ICRF-187 -LRB- dexrazoxane -RRB- and ICRF-186 by dihydropyrimidine_amidohydrolase .
9260868	0	dexrazoxane	49,60	transferrin_receptor	14,34	dexrazoxane	transferrin receptor	MESH:D011929	7037	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Modulation of transferrin_receptor expression by dexrazoxane -LRB- ICRF-187 -RRB- via activation of iron regulatory protein .
27004522	0	dextran_sulphate	69,85	HIF-1a	111,117	dextran sulphate	HIF-1a	CHEBI:34674	3091	Chemical	Gene	START_ENTITY|nmod|reduction reduction|nmod|END_ENTITY	Inhibition of peritoneal metastasis of human gastric_cancer cells by dextran_sulphate through the reduction in HIF-1a and ITGb1 expression .
10510150	0	dextromethorphan	26,42	CYP2D6	58,64	dextromethorphan	CYP2D6	MESH:D003915	1565	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|compound|END_ENTITY	The antitussive effect of dextromethorphan in relation to CYP2D6 activity .
16239355	0	dextromethorphan	38,54	CYP2D6	14,20	dextromethorphan	CYP2D6	MESH:D003915	1565	Chemical	Gene	metabolism|compound|START_ENTITY polymorphisms|nmod|metabolism polymorphisms|nsubj|effect effect|nmod|END_ENTITY	The effect of CYP2D6 polymorphisms on dextromethorphan metabolism in Mexican Americans .
7826826	0	dextromethorphan	68,84	CYP2D6	12,18	dextromethorphan	CYP2D6	MESH:D003915	1565	Chemical	Gene	metabolism|nmod|START_ENTITY END_ENTITY|nmod|metabolism	The role of CYP2D6 in primary and secondary oxidative metabolism of dextromethorphan : in vitro studies using human liver microsomes .
8220439	0	dextromethorphan	42,58	CYP2D6	0,6	dextromethorphan	CYP2D6	MESH:D003915	1565	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|amod|END_ENTITY	CYP2D6 - and CYP3A-dependent metabolism of dextromethorphan in humans .
21704706	0	dextromethorphan	9,25	NOX2	102,106	dextromethorphan	NOX2	MESH:D003915	1536	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|advcl|inhibiting inhibiting|dobj|END_ENTITY	Low dose dextromethorphan attenuates moderate experimental_autoimmune_encephalomyelitis by inhibiting NOX2 and reducing peripheral immune cells infiltration in the spinal cord .
9863163	0	dextromethorphan	22,38	c-fos	42,47	dextromethorphan	c-fos	MESH:D003915	314322(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|amod|END_ENTITY	Inhibitory effects of dextromethorphan on c-fos protein expression during focal cerebral_ischemia in rats .
19764564	0	dextrose	23,31	CD44	58,62	dextrose	CD44	MESH:D005947	960	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of CO2_and_5 % dextrose solution on expression of CD44 and ICAM-1 in endometrial_carcinoma cells -RSB- .
17593826	0	dextrose	26,34	CO2	16,19	dextrose	CO2	MESH:D005947	717	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	-LSB- Effect of 100 % CO2 or 5 % dextrose as distending uterine cavity medium on the proliferation and apoptosis of endometrial_carcinoma cell in vitro -RSB- .
20027226	0	dh404	35,40	Nrf2	51,55	dh404	Nrf2	null	4780	Chemical	Gene	START_ENTITY|appos|activator activator|amod|END_ENTITY	Dihydro-CDDO-trifluoroethyl_amide -LRB- dh404 -RRB- , a novel Nrf2 activator , suppresses oxidative stress in cardiomyocytes .
9010488	0	di-catechol_rooperol	21,41	VCAM-1	45,51	di-catechol rooperol	VCAM-1	null	22329(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|amod|END_ENTITY	Inhibitory effect of di-catechol_rooperol on VCAM-1 and iNOS expression in cytokine-stimulated endothelium .
18346468	0	di-leucine	30,40	C5a_receptor	83,95	di-leucine	C5a receptor	null	728	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of the carboxyl terminal di-leucine in phosphorylation and internalization of C5a_receptor .
24042840	0	di-n-butyl_phthalate	11,31	acetylcholinesterase	57,77	di-n-butyl phthalate	acetylcholinesterase	MESH:D003993	114549(Tax:7955)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effects of di-n-butyl_phthalate and diethyl_phthalate on acetylcholinesterase activity and neurotoxicity related gene expression in embryonic zebrafish .
23707436	0	di-n-butyl_phthalate	160,180	peroxiredoxin_6	27,42	di-n-butyl phthalate	peroxiredoxin 6	MESH:D003993	94167(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Differential expression of peroxiredoxin_6 , annexin_A5 and ubiquitin_carboxyl-terminal_hydrolase_isozyme_L1 in testis of rat fetuses after maternal exposure to di-n-butyl_phthalate .
10197959	0	di-tert-butylphenols	84,104	cyclooxygenase-2	162,178	di-tert-butylphenols	cyclooxygenase-2	null	29527(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|class class|nmod|inhibitors inhibitors|amod|END_ENTITY	Synthesis , structure-activity relationships , and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent , selective , and orally active cyclooxygenase-2 inhibitors .
10197960	0	di-tert-butylphenols	84,104	cyclooxygenase-2	162,178	di-tert-butylphenols	cyclooxygenase-2	null	5743	Chemical	Gene	START_ENTITY|nmod|class class|nmod|inhibitors inhibitors|amod|END_ENTITY	Synthesis , structure-activity relationships , and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent , selective , and orally active cyclooxygenase-2 inhibitors .
1854803	0	diacyl	24,30	5-lipoxygenase	84,98	diacyl	5-lipoxygenase	null	240	Chemical	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Differential actions of diacyl - and alkylacylglycerols in priming phospholipase_A2 , 5-lipoxygenase and acetyltransferase activation in human neutrophils .
3182818	0	diacyl_phosphatidylethanolamine	97,128	phosphatidylethanolamine_N-methyltransferase	27,71	diacyl phosphatidylethanolamine	phosphatidylethanolamine N-methyltransferase	null	25511(Tax:10116)	Chemical	Gene	Specificity|nmod|START_ENTITY Specificity|nmod|END_ENTITY	Specificity of rat hepatic phosphatidylethanolamine_N-methyltransferase for molecular species of diacyl_phosphatidylethanolamine .
15907694	0	diacylglycerol	90,104	At5g13640	124,133	diacylglycerol	At5g13640	CHEBI:41847	831208(Tax:3702)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Isolation and characterization of an Arabidopsis_thaliana knockout line for phospholipid : diacylglycerol transacylase gene -LRB- At5g13640 -RRB- .
12077321	0	diacylglycerol	84,98	DGAT1	116,121	diacylglycerol	DGAT1	CHEBI:41847	282609(Tax:9913)	Chemical	Gene	acyltransferase|amod|START_ENTITY acyltransferase|appos|END_ENTITY	Association of a lysine-232 / alanine polymorphism in a bovine gene encoding acyl-CoA : diacylglycerol acyltransferase -LRB- DGAT1 -RRB- with variation at a quantitative trait locus for milk fat content .
16130466	0	diacylglycerol	26,40	DGAT1	65,70	diacylglycerol	DGAT1	CHEBI:41847	397118(Tax:9823)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Exclusion of the acyl_CoA : diacylglycerol acyltransferase 1 gene -LRB- DGAT1 -RRB- as a candidate for a fatty_acid composition QTL on porcine chromosome 4 .
16978454	0	diacylglycerol	96,110	DGAT1	130,135	diacylglycerol	DGAT1	CHEBI:41847	100861225	Chemical	Gene	acyltransferase|amod|START_ENTITY acyltransferase|dep|gene gene|compound|END_ENTITY	Identification of a single nucleotide polymorphism at intron 16 of the caprine acyl-coenzyme_A : diacylglycerol acyltransferase 1 -LRB- DGAT1 -RRB- gene .
18420645	0	diacylglycerol	109,123	DGAT1	143,148	diacylglycerol	DGAT1	CHEBI:41847	282609(Tax:9913)	Chemical	Gene	acyltransferase|amod|START_ENTITY acyltransferase|dep|1 1|appos|END_ENTITY	Milk fatty_acid unsaturation : genetic parameters and effects of stearoyl-CoA_desaturase -LRB- SCD1 -RRB- and acyl_CoA : diacylglycerol acyltransferase 1 -LRB- DGAT1 -RRB- .
24120540	0	diacylglycerol	53,67	DGAT1	87,92	diacylglycerol	DGAT1	CHEBI:41847	13350(Tax:10090)	Chemical	Gene	acyltransferase|amod|START_ENTITY acyl-CoA|dep|acyltransferase 2-aminooxazole_amides|nmod|acyl-CoA inhibitors|amod|2-aminooxazole_amides inhibitors|appos|END_ENTITY	Identification of 2-aminooxazole_amides as acyl-CoA : diacylglycerol acyltransferase 1 -LRB- DGAT1 -RRB- inhibitors through scaffold hopping strategy .
14521909	0	diacylglycerol	8,22	DGAT2	40,45	diacylglycerol	DGAT2	CHEBI:41847	84649	Chemical	Gene	acyltransferase|amod|START_ENTITY acyltransferase|appos|END_ENTITY	A novel diacylglycerol acyltransferase -LRB- DGAT2 -RRB- is decreased in human psoriatic skin and increased in diabetic mice .
20657643	0	diacylglycerol	34,48	DGK	57,60	diacylglycerol	DGK	CHEBI:41847	217480(Tax:10090)	Chemical	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	Essential role of neuron-enriched diacylglycerol kinase -LRB- DGK -RRB- , DGKbeta in neurite spine formation , contributing to cognitive function .
25862496	4	diacylglycerol	382,396	DGK	371,374	diacylglycerol	DGK	CHEBI:41847	1607	Chemical	Gene	value|nmod|START_ENTITY value|nmod|END_ENTITY	Intriguingly , the Km value of DGK 1 for diacylglycerol was at least 9-fold lower than those of other DGK isozymes including DGKa , indicating that DGK 1 is a high affinity isozyme for diacylglycerol .
22048461	0	diacylglycerol	23,37	DGKH	49,53	diacylglycerol	DGKH	CHEBI:41847	160851	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Effect of variation in diacylglycerol kinase -LRB- DGKH -RRB- gene on brain function in a cohort at familial risk of bipolar_disorder .
7883040	0	diacylglycerol	102,116	Epidermal_growth_factor	0,23	diacylglycerol	Epidermal growth factor	CHEBI:41847	13645(Tax:10090)	Chemical	Gene	generation|nmod|START_ENTITY bisphosphate|appos|generation hydrolysis|dep|bisphosphate stimulates|dobj|hydrolysis stimulates|nsubj|END_ENTITY	Epidermal_growth_factor stimulates hydrolysis of phosphatidylinositol_4 ,5 - bisphosphate , generation of diacylglycerol and exocytosis in mouse spermatozoa .
2120207	0	diacylglycerol	40,54	Insulin-like_growth_factor-I	0,28	diacylglycerol	Insulin-like growth factor-I	CHEBI:41847	3479	Chemical	Gene	production|amod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Insulin-like_growth_factor-I stimulates diacylglycerol production via multiple pathways in Balb/c 3T3 cells .
2898301	0	diacylglycerol	25,39	Interleukin-1	0,13	diacylglycerol	Interleukin-1	CHEBI:41847	3552	Chemical	Gene	production|amod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Interleukin-1 stimulates diacylglycerol production in T lymphocytes by a novel mechanism .
9729268	0	diacylglycerol	31,45	Nerve_growth_factor	0,19	diacylglycerol	Nerve growth factor	CHEBI:41847	310738(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY stimulates|dobj|synthesis stimulates|nsubj|END_ENTITY	Nerve_growth_factor stimulates diacylglycerol de novo synthesis and phosphatidylinositol hydrolysis in pheochromocytoma cells .
3107559	0	diacylglycerol	99,113	Phospholipase_A2	0,16	diacylglycerol	Phospholipase A2	CHEBI:41847	151056	Chemical	Gene	+|amod|START_ENTITY synergism|nmod|+ activation|dep|synergism activation|amod|END_ENTITY	Phospholipase_A2 activation in chemotactic peptide-stimulated HL60 granulocytes : synergism between diacylglycerol and Ca2 + in a protein kinase C-independent mechanism .
8538623	0	diacylglycerol	43,57	Protein_kinase_D	0,16	diacylglycerol	Protein kinase D	CHEBI:41847	5587	Chemical	Gene	target|nmod|START_ENTITY END_ENTITY|dep|target	Protein_kinase_D -LRB- PKD -RRB- : a novel target for diacylglycerol and phorbol_esters .
17532549	0	diacylglycerol	40,54	TRPC6	14,19	diacylglycerol	TRPC6	CHEBI:41847	489435(Tax:9615)	Chemical	Gene	channels|nmod|START_ENTITY channels|nummod|END_ENTITY	Activation of TRPC6 calcium channels by diacylglycerol -LRB- DAG -RRB- - containing arachidonic_acid : a comparative study with DAG-containing docosahexaenoic_acid .
9930701	0	diacylglycerol	55,69	TRPC6	27,32	diacylglycerol	TRPC6	CHEBI:41847	7225	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol .
1909650	0	diacylglycerol	59,73	epidermal_growth_factor	18,41	diacylglycerol	epidermal growth factor	CHEBI:41847	25313(Tax:10116)	Chemical	Gene	Lack|nmod|START_ENTITY Lack|nmod|END_ENTITY	Lack of effect of epidermal_growth_factor on radiolabelled diacylglycerol in rat parietal cells .
3143714	0	diacylglycerol	71,85	gonadotropin-releasing_hormone	37,67	diacylglycerol	gonadotropin-releasing hormone	CHEBI:41847	25194(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY END_ENTITY|nmod|metabolism	Dependence of secretory responses to gonadotropin-releasing_hormone on diacylglycerol metabolism .
8452754	0	diacylglycerol	84,98	gonadotropin-releasing_hormone	10,40	diacylglycerol	gonadotropin-releasing hormone	CHEBI:41847	2796	Chemical	Gene	lipase|amod|START_ENTITY activating|dobj|lipase increases|xcomp|activating increases|advmod|END_ENTITY	Mammalian gonadotropin-releasing_hormone increases PGF2 alpha production activating diacylglycerol lipase in Rana esculenta interrenal .
22425588	0	diacylglycerol	13,27	insulin	63,70	diacylglycerol	insulin	CHEBI:41847	3630	Chemical	Gene	content|amod|START_ENTITY associated|nsubjpass|content associated|nmod|resistance resistance|compound|END_ENTITY	Intrahepatic diacylglycerol content is associated with hepatic insulin resistance in obese subjects .
3044366	0	diacylglycerol	41,55	insulin	11,18	diacylglycerol	insulin	CHEBI:41847	3630	Chemical	Gene	generation|amod|START_ENTITY Effects|nmod|generation Effects|nmod|END_ENTITY	Effects of insulin and phorbol_esters on diacylglycerol generation and synthesis and hydrolysis of phosphatidylcholine in BC3H-1 myocytes .
10233166	0	diacylglycerol	18,32	munc13	6,12	diacylglycerol	munc13	CHEBI:41847	10497	Chemical	Gene	receptor|amod|START_ENTITY receptor|nsubj|END_ENTITY	Human munc13 is a diacylglycerol receptor that induces apoptosis and may contribute to renal_cell_injury in hyperglycemia .
10082810	0	diacylglycerol	49,63	nerve_growth_factor	19,38	diacylglycerol	nerve growth factor	CHEBI:41847	310738(Tax:10116)	Chemical	Gene	levels|amod|START_ENTITY increases|dobj|levels increases|nsubj|END_ENTITY	Mechanisms whereby nerve_growth_factor increases diacylglycerol levels in differentiating PC12 cells .
9395299	0	diacylglycerol	33,47	protein_kinase_C	70,86	diacylglycerol	protein kinase C	CHEBI:41847	852169(Tax:4932)	Chemical	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Mutants affected in the putative diacylglycerol binding site of yeast protein_kinase_C .
10090770	0	diacylglycerol	88,102	protein_kinase_Calpha	26,47	diacylglycerol	protein kinase Calpha	CHEBI:41847	5578	Chemical	Gene	induced|nmod|START_ENTITY activation|acl|induced activation|nmod|END_ENTITY	Synergistic activation of protein_kinase_Calpha , - betaI , and - gamma isoforms induced by diacylglycerol and phorbol_ester : roles of membrane association and activating conformational changes .
18698758	2	diacylglycerol-lactone	73,95	zip	105,108	diacylglycerol-lactone	zip	null	1613	Chemical	Gene	codes|amod|START_ENTITY codes|compound|END_ENTITY	Cells sort diacylglycerol-lactone chemical zip codes to produce diverse and selective biological activities .
15834126	0	diacylglycerols	75,90	DGAT1	37,42	diacylglycerols	DGAT1	MESH:D004075	13350(Tax:10090)	Chemical	Gene	synthesis|nmod|START_ENTITY catalyzes|dobj|synthesis catalyzes|nsubj|END_ENTITY	The triacylglycerol synthesis enzyme DGAT1 also catalyzes the synthesis of diacylglycerols , waxes , and retinyl_esters .
231173	0	diacylglycerols	49,64	Ethanolamine_kinase	0,19	diacylglycerols	Ethanolamine kinase	MESH:D004075	29367(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Ethanolamine_kinase activity and compositions of diacylglycerols , phosphatidylcholines and phosphatidylethanolamines in livers of choline-deficient rats .
1168195	0	diacylglycerols	14,29	lipoprotein_lipase	33,51	diacylglycerols	lipoprotein lipase	MESH:D004075	280843(Tax:9913)	Chemical	Gene	Hydrolysis|nmod|START_ENTITY Hydrolysis|nmod|END_ENTITY	Hydrolysis of diacylglycerols by lipoprotein_lipase .
9183747	0	diacylgylcerol	46,60	rdgA	69,73	diacylgylcerol	rdgA	null	31826(Tax:7227)	Chemical	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	Immunolocalization of Drosophila eye-specific diacylgylcerol kinase , rdgA , which is essential for the maintenance of the photoreceptor .
24859762	0	diacylhydrazine	9,24	polo-like_kinase_1	55,73	diacylhydrazine	polo-like kinase 1	null	5347	Chemical	Gene	START_ENTITY|nmod|class class|nmod|inhibitors inhibitors|amod|END_ENTITY	Aromatic diacylhydrazine derivatives as a new class of polo-like_kinase_1 -LRB- PLK1 -RRB- inhibitors .
7184513	0	diadenosine_polyphosphates	22,48	terminal_deoxynucleotidyltransferase	83,119	diadenosine polyphosphates	terminal deoxynucleotidyltransferase	CHEBI:64603	281120(Tax:9913)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Inhibitory effects of diadenosine_polyphosphates and diguanosine_polyphosphates on terminal_deoxynucleotidyltransferase from calf thymus .
7255190	0	diadenosine_polyphosphates	62,88	terminal_deoxynucleotidyltransferase	14,50	diadenosine polyphosphates	terminal deoxynucleotidyltransferase	CHEBI:64603	1791	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of terminal_deoxynucleotidyltransferase by various diadenosine_polyphosphates .
10834783	0	dialdehyde	74,84	superoxide_dismutase	43,63	dialdehyde	superoxide dismutase	CHEBI:38124	6647	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|treatment treatment|nmod|END_ENTITY	Effect of high-dose lidocaine treatment on superoxide_dismutase and malon dialdehyde levels in seven diabetic patients .
23203057	0	diallyl_disulfide	63,80	JNK	99,102	diallyl disulfide	JNK	MESH:C028009	5599	Chemical	Gene	START_ENTITY|nmod|modulation modulation|nmod|END_ENTITY	Apoptosis induction of human prostate_carcinoma DU145 cells by diallyl_disulfide via modulation of JNK and PI3K/AKT signaling pathways .
24246655	0	diallyl_disulfide	53,70	Nrf2	19,23	diallyl disulfide	Nrf2	MESH:C028009	83619(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nmod|effects	The involvement of Nrf2 in the protective effects of diallyl_disulfide on carbon_tetrachloride-induced hepatic oxidative damage and inflammatory response in rats .
24293383	0	diallyl_disulfide	22,39	Nrf2	109,113	diallyl disulfide	Nrf2	MESH:C028009	83619(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Protective effects of diallyl_disulfide on carbon_tetrachloride-induced hepatotoxicity through activation of Nrf2 .
16638182	0	diallyl_disulfide	11,28	VEGF	60,64	diallyl disulfide	VEGF	MESH:C028009	7422	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of diallyl_disulfide on expression and secretion of VEGF in HL-60 leukemic cells -RSB- .
17278431	0	diallyl_disulfide	11,28	VEGF	64,68	diallyl disulfide	VEGF	MESH:C028009	7422	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of diallyl_disulfide on the expression and secretion of VEGF in HL-60 cells -RSB- .
21698271	0	diallyl_sulfide	15,30	CAR	64,67	diallyl sulfide	CAR	MESH:C038491	12355(Tax:10090)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Garlic extract diallyl_sulfide -LRB- DAS -RRB- activates nuclear receptor CAR to induce the Sult1e1 gene in mouse liver .
14667466	0	diallyl_sulfide	99,114	N-acetyltransferase	14,33	diallyl sulfide	N-acetyltransferase	MESH:C038491	6046	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activity activity|amod|END_ENTITY	Inhibition of N-acetyltransferase activity and gene expression in human colon_cancer cell lines by diallyl_sulfide .
18573668	0	diallyl_sulfide	45,60	cyclooxygenase_2	14,30	diallyl sulfide	cyclooxygenase 2	MESH:C038491	29527(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Inhibition of cyclooxygenase_2 expression by diallyl_sulfide on joint_inflammation induced by urate crystal and IL-1beta .
15542785	0	diallyl_sulfide	75,90	p53	14,17	diallyl sulfide	p53	MESH:C038491	22060(Tax:10090)	Chemical	Gene	-LSB-|nmod|START_ENTITY -LSB-|nsubj|Modulation Modulation|nmod|END_ENTITY	Modulation of p53 in 7,12-dimethylbenz -LSB- a -RSB- anthracene-induced skin_tumors by diallyl_sulfide in Swiss albino mice .
17448272	0	diallyl_trisulfide	11,29	tumor_necrosis_factor-alpha	33,60	diallyl trisulfide	tumor necrosis factor-alpha	MESH:C042577	21926(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effect of diallyl_trisulfide on tumor_necrosis_factor-alpha expression and nuclear_factor-KappaB activity in mice with acute_lung_injury induced by lipopolysaccharide -RSB- .
18992798	0	diallylsulfide	32,46	CYP2E1	60,66	diallylsulfide	CYP2E1	MESH:C038491	25086(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Oxidative stress potentiated by diallylsulfide , a selective CYP2E1 inhibitor , in isoniazid toxic effect on rat primary hepatocytes .
24364277	0	dialysate	26,35	myoglobin	36,45	dialysate	myoglobin	null	59108(Tax:10116)	Chemical	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	-LSB- Effect of propranolol on dialysate myoglobin levels evoked by ischemia/reperfusion -RSB- .
10848984	0	diamide	14,21	oxidoreductase	22,36	diamide	oxidoreductase	MESH:D003958	827783(Tax:3702)	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	A novel NADPH : diamide oxidoreductase activity in arabidopsis_thaliana P1 zeta-crystallin .
1765146	0	diamide	55,62	protein_tyrosine_phosphatase	14,42	diamide	protein tyrosine phosphatase	MESH:D003958	26191	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Inhibition of protein_tyrosine_phosphatase activity by diamide is reversed by epidermal growth factor in fibroblasts .
2872883	0	diamines	69,77	Ornithine_decarboxylase	0,23	diamines	Ornithine decarboxylase	MESH:D003959	24609(Tax:10116)	Chemical	Gene	diamine_oxidase|dobj|START_ENTITY diamine_oxidase|nsubj|END_ENTITY	Ornithine_decarboxylase , transglutaminase , diamine_oxidase and total diamines and polyamines in maternal liver and kidney throughout rat pregnancy .
3934184	0	diamines	66,74	ornithine_decarboxylase	14,37	diamines	ornithine decarboxylase	MESH:D003959	4953	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Inhibition of ornithine_decarboxylase activity and cell growth by diamines : a comparison between the effects of two homologs , 1,3-diaminopropane and 1,4-diaminobutane -LRB- putrescine -RRB- .
7396844	0	diamines	55,63	ornithine_decarboxylase	14,37	diamines	ornithine decarboxylase	MESH:D003959	4953	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of ornithine_decarboxylase of HeLa cells by diamines and polyamines .
20000379	0	diaminocyclitols	33,49	neuraminidase	83,96	diaminocyclitols	neuraminidase	null	4758	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Development of new stereodiverse diaminocyclitols as inhibitors of influenza virus neuraminidase .
12796777	0	diaminopimelic_acid	85,104	NOD1	22,26	diaminopimelic acid	NOD1	MESH:D003960	107607(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic_acid .
301777	0	diaminopyrimidine	14,31	dihydrofolate_reductase	46,69	diaminopyrimidine	dihydrofolate reductase	null	1719	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|nmod|END_ENTITY	Lipid-soluble diaminopyrimidine inhibitors of dihydrofolate_reductase .
25046358	0	diaporine_A	32,43	mTOR	109,113	diaporine A	mTOR	null	21977(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|regulating regulating|dobj|END_ENTITY	A novel small-molecule compound diaporine_A inhibits non-small cell lung_cancer growth by regulating miR-99a / mTOR signaling .
17958345	0	diaryl_phosphonates	71,90	dipeptidyl_peptidase_8	27,49	diaryl phosphonates	dipeptidyl peptidase 8	null	54878	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Irreversible inhibition of dipeptidyl_peptidase_8 by dipeptide-derived diaryl_phosphonates .
15801845	0	diaryl_sulfides	12,27	serotonin_transporter	31,52	diaryl sulfides	serotonin transporter	null	25553(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|ligands ligands|compound|END_ENTITY	Fluorinated diaryl_sulfides as serotonin_transporter ligands : synthesis , structure-activity relationship study , and in vivo evaluation of fluorine-18-labeled compounds as PET imaging agents .
20493697	0	diaryl_sulfones	69,84	5-HT2A_receptor	119,134	diaryl sulfones	5-HT2A receptor	null	3356	Chemical	Gene	START_ENTITY|nmod|antagonists antagonists|amod|END_ENTITY	Non-basic ligands for aminergic GPCRs : the discovery and development diaryl_sulfones as selective , orally bioavailable 5-HT2A_receptor antagonists for the treatment of sleep_disorders .
12008053	1	diarylcyclopentenyl	128,147	cyclooxygenase-2	148,164	diarylcyclopentenyl	cyclooxygenase-2	null	5743	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Methyleneaminoxymethyl -LRB- MAOM -RRB- analogues of diarylcyclopentenyl cyclooxygenase-2 inhibitors : synthesis and biological properties .
12126777	0	diarylcyclopentenyl	60,79	cyclooxygenase-2	80,96	diarylcyclopentenyl	cyclooxygenase-2	null	5743	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Aryl-substituted methyleneaminoxymethyl -LRB- MAOM -RRB- analogues of diarylcyclopentenyl cyclooxygenase-2 inhibitors : effects of some structural modifications on their biological properties .
10784440	0	diarylheptanoids	45,61	cyclooxygenase-2	14,30	diarylheptanoids	cyclooxygenase-2	MESH:D036381	5743	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Inhibition of cyclooxygenase-2 expression by diarylheptanoids from the bark of Alnus hirsuta var .
23651359	0	diarylisoxazoles	87,103	cyclooxygenase-1	124,140	diarylisoxazoles	cyclooxygenase-1	null	5742	Chemical	Gene	analysis|nmod|START_ENTITY analysis|nmod|END_ENTITY	Synthesis , pharmacological characterization , and docking analysis of a novel family of diarylisoxazoles as highly selective cyclooxygenase-1 -LRB- COX-1 -RRB- inhibitors .
1318081	0	diazepam	40,48	Adrenocorticotropin	0,19	diazepam	Adrenocorticotropin	MESH:D003975	5443	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Adrenocorticotropin hormone response to diazepam in healthy young men .
8948091	0	diazepam	23,31	CYP2B6	90,96	diazepam	CYP2B6	MESH:D003975	1555	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|dep|role role|nmod|END_ENTITY	Human liver microsomal diazepam metabolism using cDNA-expressed cytochrome_P450s : role of CYP2B6 , 2C19 and the 3A subfamily .
25903735	0	diazepam	61,69	GABAA	26,31	diazepam	GABAA	MESH:D003975	14405(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|nmod|receptors receptors|compound|END_ENTITY	Immune cell expression of GABAA receptors and the effects of diazepam on influenza_infection .
2183879	4	diazepam	588,596	GH	572,574	diazepam	GH	MESH:D003975	2688	Chemical	Gene	responses|nmod|START_ENTITY responses|compound|END_ENTITY	Individual GH responses to diazepam were variable and , when a cut-off point of 7.5 ng/ml GH increase before 90 min postdrug administration was used , 1 % of the men demonstrated a response after placebo , 17 % after low-dose diazepam , and 37 % following high-dose diazepam .
2183879	0	diazepam	39,47	Growth_hormone	0,14	diazepam	Growth hormone	MESH:D003975	2688	Chemical	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Growth_hormone response to intravenous diazepam and placebo in 82 healthy men .
2492934	0	diazepam	27,35	Growth_hormone	0,14	diazepam	Growth hormone	MESH:D003975	2688	Chemical	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Growth_hormone response to diazepam , clonidine and glucagon in patients with epilepsy .
19914403	0	diazepam	22,30	IFN-gamma	34,43	diazepam	IFN-gamma	MESH:D003975	3458	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|production production|amod|END_ENTITY	Suppressive effect of diazepam on IFN-gamma production by human T cells .
15713338	0	diazepam	17,25	IL-1_beta	56,65	diazepam	IL-1 beta	MESH:D003975	24494(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	Effects of HI 6 , diazepam and atropine on soman-induced IL-1_beta protein in rat brain .
19782064	0	diazepam	65,73	Translocator_protein	0,20	diazepam	Translocator protein	MESH:D003975	12257(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY mediates|dobj|effects mediates|nsubj|END_ENTITY	Translocator_protein -LRB- 18 kDa -RRB- mediates the pro-growth effects of diazepam on Ehrlich tumor cells in vivo .
16227652	0	diazepam	10,18	VEGF	104,108	diazepam	VEGF	MESH:D003975	22339(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of diazepam and chlorpromazine on proliferative activity and vascular_endothelial_growth_factor -LRB- VEGF -RRB- secretion from cultured endothelial HECa10 cells in vitro .
16168624	0	diazepam	21,29	beta3	68,73	diazepam	beta3	MESH:D003975	12297(Tax:10090)	Chemical	Gene	treatment|compound|START_ENTITY treatment|nmod|END_ENTITY	Long-term effects of diazepam treatment of epileptic GABAA receptor beta3 subunit knockout mouse in early life .
1100541	0	diazepam	102,110	growth_hormone	6,20	diazepam	growth hormone	MESH:D003975	2688	Chemical	Gene	Serum|nmod|START_ENTITY Serum|dobj|insulin insulin|amod|END_ENTITY	Serum growth_hormone , serum immunoreactive insulin and blood glucose response to oral and intravenous diazepam in man .
20575772	0	diazepam	10,18	growth_hormone	22,36	diazepam	growth hormone	MESH:D003975	2688	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|amod|END_ENTITY	Effect of diazepam on growth_hormone secretion in abstinent alcoholic men .
2871466	0	diazepam	32,40	growth_hormone	107,121	diazepam	growth hormone	MESH:D003975	81668(Tax:10116)	Chemical	Gene	contrast|nmod|START_ENTITY alprazolam|nmod|contrast activate|nsubj|alprazolam activate|dobj|secretion secretion|amod|END_ENTITY	Does alprazolam , in contrast to diazepam , activate alpha 2-adrenoceptors involved in the regulation of rat growth_hormone secretion ?
3749390	0	diazepam	12,20	growth_hormone	37,51	diazepam	growth hormone	MESH:D003975	2688	Chemical	Gene	fails|nsubj|START_ENTITY fails|xcomp|change change|dobj|secretion secretion|amod|END_ENTITY	Intravenous diazepam fails to change growth_hormone and cortisol secretion in humans .
6642424	0	diazepam	11,19	growth_hormone	30,44	diazepam	growth hormone	MESH:D003975	2688	Chemical	Gene	Failure|nmod|START_ENTITY Failure|acl|affect affect|dobj|END_ENTITY	Failure of diazepam to affect growth_hormone and prolactin in acromegalics .
6706293	0	diazepam	63,71	growth_hormone	45,59	diazepam	growth hormone	MESH:D003975	2688	Chemical	Gene	confirm|nmod|START_ENTITY confirm|dobj|stimulation stimulation|nmod|END_ENTITY	Failure to confirm consistent stimulation of growth_hormone by diazepam .
7108150	0	diazepam	53,61	growth_hormone	16,30	diazepam	growth hormone	MESH:D003975	2688	Chemical	Gene	response|nmod|START_ENTITY response|nmod|END_ENTITY	The response of growth_hormone and prolactin to oral diazepam in diabetics .
7178369	0	diazepam	101,109	growth_hormone	54,68	diazepam	growth hormone	MESH:D003975	2688	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|amod|phentolamine phentolamine|nmod|END_ENTITY	Inhibitory effect of phentolamine on diazepam-induced growth_hormone secretion and lack of effect of diazepam on prolactin secretion in man .
7203397	0	diazepam	91,99	growth_hormone	21,35	diazepam	growth hormone	MESH:D003975	2688	Chemical	Gene	response|nmod|START_ENTITY response|compound|prolactin prolactin|compound|END_ENTITY	Effect of glucose of growth_hormone , prolactin and thyroid-stimulating hormone response to diazepam in normal subjects .
3714907	0	diazepam	9,17	ornithine_decarboxylase	36,59	diazepam	ornithine decarboxylase	MESH:D003975	4953	Chemical	Gene	exposure|compound|START_ENTITY exposure|nmod|END_ENTITY	Maternal diazepam exposure on brain ornithine_decarboxylase and growth of offspring .
6320963	0	diazepam	27,35	prolactin	79,88	diazepam	prolactin	MESH:D003975	24683(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|compound|END_ENTITY	The benzodiazepine agonist diazepam inhibits basal and secretagogue-stimulated prolactin release in vitro .
7178369	0	diazepam	101,109	prolactin	113,122	diazepam	prolactin	MESH:D003975	5617	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Inhibitory effect of phentolamine on diazepam-induced growth_hormone secretion and lack of effect of diazepam on prolactin secretion in man .
7203397	0	diazepam	91,99	prolactin	37,46	diazepam	prolactin	MESH:D003975	5617	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Effect of glucose of growth_hormone , prolactin and thyroid-stimulating hormone response to diazepam in normal subjects .
16221533	0	diazinon	36,44	P-glycoprotein	86,100	diazinon	P-glycoprotein	MESH:D003976	5243	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of organophosphate pesticide diazinon on expression and activity of intestinal P-glycoprotein .
1663902	0	diaziquone	68,78	DT-diaphorase	123,136	diaziquone	DT-diaphorase	MESH:C029108	24314(Tax:10116)	Chemical	Gene	oxidoreductase|amod|START_ENTITY oxidoreductase|appos|END_ENTITY	Free radical formation and DNA strand breakage during metabolism of diaziquone by NAD -LRB- P -RRB- H_quinone-acceptor oxidoreductase -LRB- DT-diaphorase -RRB- and NADPH cytochrome c reductase .
8617583	0	diaziquone	17,27	GM-CSF	39,45	diaziquone	GM-CSF	MESH:C029108	1437	Chemical	Gene	trial|nmod|START_ENTITY trial|nmod|END_ENTITY	Phase I trial of diaziquone -LRB- AZQ -RRB- plus GM-CSF .
9548807	0	diaziquone	79,89	p53	13,16	diaziquone	p53	MESH:C029108	7157	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of p53 by the concerted actions of aziridine and quinone moieties of diaziquone .
24144283	0	diazobenzene	34,46	BET	66,69	diazobenzene	BET	CHEBI:190358	227325(Tax:10090)	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|nmod|END_ENTITY	Structure-guided design of potent diazobenzene inhibitors for the BET bromodomains .
21620734	0	diazoxide	56,65	Heat_shock_protein_90	0,21	diazoxide	Heat shock protein 90	MESH:D003981	299331(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY mediates|dobj|effect mediates|nsubj|END_ENTITY	Heat_shock_protein_90 mediates anti-apoptotic effect of diazoxide by preventing the cleavage of Bid in hypothermic preservation rat hearts .
9724074	0	diazoxide	86,95	Leptin	0,6	diazoxide	Leptin	MESH:D003981	3952	Chemical	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	Leptin levels in women with polycystic_ovary_syndrome before and after treatment with diazoxide .
17587399	0	diazoxide	48,57	insulin	27,34	diazoxide	insulin	MESH:D003981	3630	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|effect effect|nmod|inhibition inhibition|nmod|END_ENTITY	No effect of inhibition of insulin secretion by diazoxide on weight_loss in hyperinsulinaemic obese subjects during an 8-week weight-loss diet .
23303986	0	diazoxide	56,65	insulin	43,50	diazoxide	insulin	MESH:D003981	3630	Chemical	Gene	decreasing|nmod|START_ENTITY decreasing|dobj|END_ENTITY	A pilot study : effects of decreasing serum insulin with diazoxide on vitamin_D levels in obese women with polycystic_ovary_syndrome .
3949281	0	diazoxide	39,48	insulin	14,21	diazoxide	insulin	MESH:D003981	3630	Chemical	Gene	resistance|nmod|START_ENTITY resistance|compound|END_ENTITY	Post-receptor insulin resistance after diazoxide in non-insulin_dependent_diabetes .
4158956	0	diazoxide	11,20	insulin	24,31	diazoxide	insulin	MESH:D003981	3630	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of diazoxide on insulin secretion in vitro .
55717	0	diazoxide	51,60	insulin	15,22	diazoxide	insulin	MESH:D003981	3630	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Improvement Improvement|nmod|END_ENTITY	Improvement in insulin secretion in diabetes after diazoxide .
8344209	0	diazoxide	38,47	insulin	16,23	diazoxide	insulin	MESH:D003981	3630	Chemical	Gene	Modification|nmod|START_ENTITY Modification|nmod|resistance resistance|compound|END_ENTITY	Modification of insulin resistance by diazoxide in obese Zucker rats .
1175686	0	diazoxide	38,47	renin	19,24	diazoxide	renin	MESH:D003981	24715(Tax:10116)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|stimulation stimulation|nmod|END_ENTITY	The stimulation of renin secretion by diazoxide in the isolated rat kidney .
1988669	0	diazoxide	43,52	renin	25,30	diazoxide	renin	MESH:D003981	5972	Chemical	Gene	potentiates|xcomp|START_ENTITY potentiates|dobj|response response|compound|END_ENTITY	Caffeine potentiates the renin response to diazoxide in man .
18794787	0	dibenzodioxepinone	41,59	cholesteryl_ester_transfer_protein	98,132	dibenzodioxepinone	cholesteryl ester transfer protein	null	1071	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	CoMFA , CoMSIA and eigenvalue analysis on dibenzodioxepinone and dibenzodioxocinone derivatives as cholesteryl_ester_transfer_protein inhibitors .
2744279	0	dibenzothiophene	23,39	CD-1	49,53	dibenzothiophene	CD-1	MESH:C016366	111334(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|compound|END_ENTITY	Acute oral_toxicity of dibenzothiophene for male CD-1 mice : LD50 , lesions , and the effect of preinduction of mixed-function oxidases .
17595765	0	dibenzoylmethane	47,63	androgen_receptor	15,32	dibenzoylmethane	androgen receptor	MESH:C061481	367	Chemical	Gene	Suppression|nmod|START_ENTITY Suppression|nmod|expression expression|compound|END_ENTITY	Suppression of androgen_receptor expression by dibenzoylmethane as a therapeutic objective in advanced prostate_cancer .
23305452	0	dibenzylideneacetone	20,40	specificity_protein_1	80,101	dibenzylideneacetone	specificity protein 1	MESH:C533260	6667	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Apoptotic effect of dibenzylideneacetone on oral_cancer cells via modulation of specificity_protein_1 and Bax .
11922777	0	dibromosulfophthalein	80,101	multidrug_resistance_protein_2	12,42	dibromosulfophthalein	multidrug resistance protein 2	null	24891(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of rat multidrug_resistance_protein_2 in plasma and biliary disposition of dibromosulfophthalein after microsomal enzyme induction .
18707063	0	dibutyltin_diacetate	50,70	CO2	102,105	dibutyltin diacetate	CO2	MESH:C004924	717	Chemical	Gene	study|nmod|START_ENTITY END_ENTITY|nsubj|study	A combined spectroscopic and theoretical study of dibutyltin_diacetate and dilaurate in supercritical CO2 .
8393869	0	dibutyryl_cAMP	61,75	GLUT4	0,5	dibutyryl cAMP	GLUT4	CHEBI:50095	403673(Tax:9615)	Chemical	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	GLUT4 phosphorylation and inhibition of glucose transport by dibutyryl_cAMP .
10697805	9	dibutyryl_cAMP	1584,1598	ICAM-1	1653,1659	dibutyryl cAMP	ICAM-1	CHEBI:50095	3383	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	As EP2 and EP4 receptors are linked to elevation of intracellular cyclic_AMP -LRB- cAMP -RRB- , the effect of dibutyryl_cAMP and 8-bromo-cAMP , cAMP analogs , on TNF_alpha-elicited ICAM-1 expression was examined .
8748156	0	dibutyryl_cAMP	11,25	N-acetylglucosaminyltransferases_III_and_V	65,107	dibutyryl cAMP	N-acetylglucosaminyltransferases III and V	CHEBI:50095	4248;4249	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of dibutyryl_cAMP and bromodeoxyuridine on expression of N-acetylglucosaminyltransferases_III_and_V in GOTO neuroblastoma cells .
8386116	0	dibutyryl_cAMP	64,78	calcitonin/CGRP-I	15,32	dibutyryl cAMP	calcitonin/CGRP-I	CHEBI:50095	796	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Stimulation of calcitonin/CGRP-I and CGRP-II gene expression by dibutyryl_cAMP in a human medullary_thyroid_carcinoma -LRB- TT -RRB- cell line .
1316128	0	dibutyryl_cAMP	68,82	ferrochelatase	36,50	dibutyryl cAMP	ferrochelatase	CHEBI:50095	361338(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Regulation of phenobarbital-induced ferrochelatase mRNA activity by dibutyryl_cAMP and glucose in normal and diabetic rat hepatocytes .
11927399	0	dibutyryl_cAMP	11,25	stanniocalcin	29,42	dibutyryl cAMP	stanniocalcin	CHEBI:50095	20855(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of dibutyryl_cAMP on stanniocalcin and stanniocalcin-related protein mRNA expression in neuroblastoma cells .
1663800	0	dibutyryl_cAMP	58,72	thrombomodulin	20,34	dibutyryl cAMP	thrombomodulin	CHEBI:50095	7056	Chemical	Gene	biosynthesis|nmod|START_ENTITY biosynthesis|nmod|END_ENTITY	The biosynthesis of thrombomodulin and its enhancement by dibutyryl_cAMP in a human megakaryoblastic cell line , UT-7 .
6123556	0	dibutyryl_cyclic_AMP	37,57	C-6	61,64	dibutyryl cyclic AMP	C-6	MESH:D003994	729	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Induction of glutamine synthetase by dibutyryl_cyclic_AMP in C-6 glioma cells .
7982855	0	dibutyryl_cyclic_AMP	10,30	Fc_gamma_receptor	55,72	dibutyryl cyclic AMP	Fc gamma receptor	MESH:D003994	2209	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of dibutyryl_cyclic_AMP and interferon-gamma on Fc_gamma_receptor expression on eosinophils .
8394282	0	dibutyryl_cyclic_AMP	114,134	Fc_gamma_receptor_III	41,62	dibutyryl cyclic AMP	Fc gamma receptor III	MESH:D003994	2214	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|expression expression|compound|END_ENTITY	Induction of phosphatidylinositol-linked Fc_gamma_receptor_III expression on an eosinophilic cell line , EoL-1 , by dibutyryl_cyclic_AMP and interferon-gamma .
2986550	0	dibutyryl_cyclic_AMP	105,125	P-450_and_adrenodoxin	189,210	dibutyryl cyclic AMP	P-450 and adrenodoxin	MESH:D003994	1555	Chemical	Gene	START_ENTITY|nmod|synthesis synthesis|nmod|END_ENTITY	Regulation of steroidogenesis in rat Leydig cells in culture : effect of human chorionic gonadotropin and dibutyryl_cyclic_AMP on the synthesis of cholesterol side chain cleavage cytochrome P-450_and_adrenodoxin .
9048735	0	dibutyryl_cyclic_AMP	64,84	amyloid_precursor_protein	23,48	dibutyryl cyclic AMP	amyloid precursor protein	MESH:D003994	11820(Tax:10090)	Chemical	Gene	response|nmod|START_ENTITY END_ENTITY|nmod|response	Enhanced expression of amyloid_precursor_protein in response to dibutyryl_cyclic_AMP is not mediated by the transcription factor AP-2 .
6323779	1	dibutyryl_cyclic_AMP	147,167	cyclic_AMP	90,100	dibutyryl cyclic AMP	cyclic AMP	MESH:D003994	442947(Tax:9615)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of cyclic_AMP in ventricular_fibrillation and the effect of dibutyryl_cyclic_AMP .
2539438	0	dibutyryl_cyclic_AMP	103,123	intermediate_filament_associated_protein	16,56	dibutyryl cyclic AMP	intermediate filament associated protein	MESH:D003994	126638	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|END_ENTITY	A 48 kilodalton intermediate_filament_associated_protein -LRB- IFAP -RRB- in reactive-like astrocytes induced by dibutyryl_cyclic_AMP in culture and in reactive astrocytes in situ .
2826237	0	dibutyryl_cyclic_AMP	10,30	lipoprotein_lipase	51,69	dibutyryl cyclic AMP	lipoprotein lipase	MESH:D003994	4023	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|amod|END_ENTITY	Effect of dibutyryl_cyclic_AMP and theophylline on lipoprotein_lipase secretion by human monocyte-derived macrophages .
2823959	0	dibutyryl_cyclic_AMP	98,118	nerve_growth_factor	14,33	dibutyryl cyclic AMP	nerve growth factor	MESH:D003994	18049(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY Regulation|dep|effects Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of nerve_growth_factor gene expression in primary brain monolayer cultures : effects of dibutyryl_cyclic_AMP and sodium_butyrate .
9075066	0	dibutyryl_cyclic_AMP	10,30	renin	41,46	dibutyryl cyclic AMP	renin	MESH:D003994	5972	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|compound|END_ENTITY	Effect of dibutyryl_cyclic_AMP on plasma renin activity in normal men and patients with primary_aldosteronism .
7499862	0	dibutyryl_cyclic_adenosine_monophosphate	46,86	IL-10	0,5	dibutyryl cyclic adenosine monophosphate	IL-10	null	16153(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY involved|nmod|effect involved|nsubjpass|END_ENTITY	IL-10 is involved in the protective effect of dibutyryl_cyclic_adenosine_monophosphate on endotoxin-induced inflammatory liver_injury .
21496886	0	dibutyryl_cyclic_adenosine_monophosphate	10,50	plasminogen_activator_inhibitor-1	77,110	dibutyryl cyclic adenosine monophosphate	plasminogen activator inhibitor-1	null	5054	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	Effect of dibutyryl_cyclic_adenosine_monophosphate on the gene expression of plasminogen_activator_inhibitor-1 and tissue_factor in adipocytes .
11955058	0	dicalcium	32,41	calbindin_D9k	47,60	dicalcium	calbindin D9k	null	795	Chemical	Gene	study|nmod|START_ENTITY END_ENTITY|dep|study	A 15N NMR mobility study on the dicalcium P43M calbindin_D9k and its mono-La3 + - substituted form .
19103312	0	dicarbonyl	39,49	alpha-synuclein	20,35	dicarbonyl	alpha-synuclein	null	6622	Chemical	Gene	compounds|amod|START_ENTITY END_ENTITY|nmod|compounds	The modification of alpha-synuclein by dicarbonyl compounds inhibits its fibril-forming process .
7896773	0	dicarbopolyborate	38,55	mitochondrial_ATPase	14,34	dicarbopolyborate	mitochondrial ATPase	null	514	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of mitochondrial_ATPase by dicarbopolyborate , a new enzyme inhibitor .
10360950	0	dicarboxylate	73,86	NaDC-1	102,108	dicarboxylate	NaDC-1	CHEBI:28965	378573(Tax:8355)	Chemical	Gene	cotransporter|amod|START_ENTITY cotransporter|appos|END_ENTITY	Acidic residues involved in cation and substrate interactions in the Na + / dicarboxylate cotransporter , NaDC-1 .
10446305	0	dicarboxylate	56,69	NaDC-1	85,91	dicarboxylate	NaDC-1	CHEBI:28965	378573(Tax:8355)	Chemical	Gene	cotransporter|amod|START_ENTITY cotransporter|appos|END_ENTITY	Protein kinase C-mediated regulation of the renal Na -LRB- + -RRB- / dicarboxylate cotransporter , NaDC-1 .
9277403	0	dicarboxylate	70,83	NaDC-2	22,28	dicarboxylate	NaDC-2	CHEBI:28965	378573(Tax:8355)	Chemical	Gene	transporter|amod|START_ENTITY END_ENTITY|appos|transporter	Expression cloning of NaDC-2 , an intestinal Na -LRB- + -RRB- - or Li -LRB- + -RRB- - dependent dicarboxylate transporter .
12397032	0	dicarboxylate	26,39	NaDC-3	53,59	dicarboxylate	NaDC-3	CHEBI:28965	64849	Chemical	Gene	transporter|amod|START_ENTITY transporter|amod|END_ENTITY	The renal Na -LRB- + -RRB- - dependent dicarboxylate transporter , NaDC-3 , translocates dimethyl - and disulfhydryl-compounds and contributes to renal_heavy_metal_detoxification .
16475819	0	dicarboxylate	79,92	NaDC1	108,113	dicarboxylate	NaDC1	CHEBI:28965	20500(Tax:10090)	Chemical	Gene	cotransporter|compound|START_ENTITY cotransporter|appos|END_ENTITY	Transmembrane helices 3 and 4 are involved in substrate recognition by the Na + / dicarboxylate cotransporter , NaDC1 .
20845974	0	dicarboxylate	53,66	NaDC1	81,86	dicarboxylate	NaDC1	CHEBI:28965	9058	Chemical	Gene	cotransporter|amod|START_ENTITY lithium|nmod|cotransporter isoleucine-554|nmod|lithium END_ENTITY|amod|isoleucine-554	Role of isoleucine-554 in lithium binding by the Na + / dicarboxylate cotransporter NaDC1 .
12488248	0	dicarboxylate	43,56	Organic_anion_transporter_3	0,27	dicarboxylate	Organic anion transporter 3	CHEBI:28965	83500(Tax:10116)	Chemical	Gene	exchanger|amod|START_ENTITY exchanger|nsubj|END_ENTITY	Organic_anion_transporter_3 -LRB- Slc22a8 -RRB- is a dicarboxylate exchanger indirectly coupled to the Na + gradient .
10207168	0	dicarboxylate	73,86	SDCT2	37,42	dicarboxylate	SDCT2	CHEBI:28965	444773(Tax:8355)	Chemical	Gene	START_ENTITY|nsubj|analysis analysis|nmod|END_ENTITY	Molecular and functional analysis of SDCT2 , a novel rat sodium-dependent dicarboxylate transporter .
21865262	0	dicarboxylates	28,42	sodium-dicarboxylate_cotransporter_3_and_organic_anion_transporters_1_and_3	54,129	dicarboxylates	sodium-dicarboxylate cotransporter 3 and organic anion transporters 1 and 3	CHEBI:28965	9356;9376	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Differential interaction of dicarboxylates with human sodium-dicarboxylate_cotransporter_3_and_organic_anion_transporters_1_and_3 .
1337585	0	dicarboxylic	12,24	Ca2	55,58	dicarboxylic	Ca2	null	100009156(Tax:9986)	Chemical	Gene	transport|amod|START_ENTITY transport|nmod|END_ENTITY	The role of dicarboxylic anion transport in the slower Ca2 + uptake in fetal cardiac sarcoplasmic reticulum .
24333844	0	dicarboxylic_acids	76,94	ABCD3	50,55	dicarboxylic acids	ABCD3	MESH:D003998	5825	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A role for the human peroxisomal half-transporter ABCD3 in the oxidation of dicarboxylic_acids .
11001755	0	dichloroacetate	29,44	PDH	11,14	dichloroacetate	PDH	CHEBI:36386	54704	Chemical	Gene	activation|nmod|START_ENTITY activation|nsubj|Effects Effects|nmod|END_ENTITY	Effects of PDH activation by dichloroacetate in human skeletal muscle during exercise in hypoxia .
21499304	0	dichloroacetate	99,114	SLC5A8	8,14	dichloroacetate	SLC5A8	CHEBI:36386	160728	Chemical	Gene	activity|nmod|START_ENTITY Role|nmod|activity Role|nmod|END_ENTITY	Role of SLC5A8 , a plasma membrane transporter and a tumor suppressor , in the antitumor activity of dichloroacetate .
6404058	0	dichlorodiphenyl	30,46	cytochrome_P-450	54,70	dichlorodiphenyl	cytochrome P-450	null	25251(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|level level|amod|END_ENTITY	-LSB- Effect of different doses of dichlorodiphenyl on the cytochrome_P-450 level and lipid peroxidation rate in the rat liver -RSB- .
17574386	0	dichlorodiphenylchloroethylene	13,43	vascular_endothelial_growth_factor	47,81	dichlorodiphenylchloroethylene	vascular endothelial growth factor	null	7422	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of dichlorodiphenylchloroethylene on vascular_endothelial_growth_factor and insulin-like_growth_factor in human and rat ovarian cells .
9192515	0	dichloromethylene_bisphosphonate	44,76	matrix_metalloproteinase-1	14,40	dichloromethylene bisphosphonate	matrix metalloproteinase-1	MESH:D004002	4312	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of matrix_metalloproteinase-1 by dichloromethylene_bisphosphonate -LRB- clodronate -RRB- .
7686084	0	dichlorovinylcysteine	16,37	c-fos	79,84	dichlorovinylcysteine	c-fos	null	100144486(Tax:9823)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|protooncogenes protooncogenes|amod|END_ENTITY	The nephrotoxin dichlorovinylcysteine induces expression of the protooncogenes c-fos and c-myc in LLC-PK1 cells -- a comparative investigation with growth factors and 12-O-tetradecanoylphorbolacetate .
21467751	0	dichlorvos	81,91	acetylcholinesterase	47,67	dichlorvos	acetylcholinesterase	MESH:D004006	540446(Tax:9913)	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubj|reactivation reactivation|nmod|END_ENTITY	Spontaneous reactivation and aging kinetics of acetylcholinesterase inhibited by dichlorvos and diazinon .
16153661	0	dichlorvos	10,20	glucokinase	47,58	dichlorvos	glucokinase	MESH:D004006	24385(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|compound|END_ENTITY	Effect of dichlorvos on hepatic and pancreatic glucokinase activity and gene expression , and on insulin mRNA levels .
3196159	0	dichlorvos	10,20	lipoprotein_lipase	40,58	dichlorvos	lipoprotein lipase	MESH:D004006	24539(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	Effect of dichlorvos on the activity of lipoprotein_lipase from adipose tissue , on plasma lipids and postheparin lipolytic plasma activity in rats .
16886565	2	diclofenac	472,482	COX-1	486,491	diclofenac	COX-2	MESH:D004008	26198(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	The aim of the study was to investigate the influence of NSAIDs on nitric_oxide synthesis and releasing to bloodstream Acetylsalicic_acid -LRB- ASA -RRB- and diclofenac as COX-1 and COX-2 inhibitors and nimesulide as selective COX-2 inhibitor were used in study .
20617408	0	diclofenac	138,148	COX-2	36,41	diclofenac	COX-2	MESH:D004008	5743	Chemical	Gene	chemoprevention|nmod|START_ENTITY chemoprevention|dep|PI3-kinase/Wnt PI3-kinase/Wnt|xcomp|END_ENTITY	PI3-kinase/Wnt association mediates COX-2 / PGE -LRB- 2 -RRB- pathway to inhibit apoptosis in early stages of colon carcinogenesis : chemoprevention by diclofenac .
23289871	0	diclofenac	42,52	COX-2	14,19	diclofenac	COX-2	MESH:D004008	4513	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Inhibition of COX-2 expression by topical diclofenac enhanced radiation sensitivity via enhancement of TRAIL in human prostate_adenocarcinoma xenograft model .
10950847	0	diclofenac	44,54	Cytochrome_P450	0,15	diclofenac	Cytochrome P450	MESH:D004008	4051	Chemical	Gene	interaction|nmod|START_ENTITY interaction|amod|END_ENTITY	Cytochrome_P450 3A4-mediated interaction of diclofenac and quinidine .
20485182	0	diclofenac	102,112	PPARgamma	89,98	diclofenac	PPARgamma	MESH:D004008	25664(Tax:10116)	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|END_ENTITY	Modulation of inflammatory changes in early stages of colon_cancer through activation of PPARgamma by diclofenac .
15517155	0	diclofenac	21,31	cyclooxygenase-2	46,62	diclofenac	cyclooxygenase-2	MESH:D004008	5743	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	-LSB- In vitro effects of diclofenac and selective cyclooxygenase-2 inhibitors on prostaglandin release from inflamed bursa subacromialis tissue in patients with subacromial_syndrome -RSB- .
19219624	0	diclofenac	77,87	cyclooxygenase-2	116,132	diclofenac	cyclooxygenase-2	MESH:D004008	19225(Tax:10090)	Chemical	Gene	results|amod|START_ENTITY peroxisome_proliferator-activated_receptor-gamma|nmod|results peroxisome_proliferator-activated_receptor-gamma|nmod|induction induction|nmod|protein protein|amod|END_ENTITY	Activation of macrophage peroxisome_proliferator-activated_receptor-gamma by diclofenac results in the induction of cyclooxygenase-2 protein and the synthesis of anti-inflammatory cytokines .
21135559	0	diclofenac	10,20	cyclooxygenase-2	24,40	diclofenac	cyclooxygenase-2	MESH:D004008	29527(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|amod|END_ENTITY	Effect of diclofenac on cyclooxygenase-2 levels and early breaking strength of experimental colonic anastomoses and skin incisions .
12534640	0	diclofenac	20,30	cyclooxygenases_1_and_2	49,72	diclofenac	cyclooxygenases 1 and 2	MESH:D004008	5742;5743	Chemical	Gene	Pharmacokinetics|nmod|START_ENTITY Pharmacokinetics|nmod|END_ENTITY	Pharmacokinetics of diclofenac and inhibition of cyclooxygenases_1_and_2 : no relationship to the CYP2C9 genetic polymorphism in humans .
8605291	0	diclofenac	109,119	dipeptidyl_peptidase_IV	35,58	diclofenac	dipeptidyl peptidase IV	MESH:D004008	25253(Tax:10116)	Chemical	Gene	modification|nmod|START_ENTITY modification|nmod|END_ENTITY	Covalent modification of rat liver dipeptidyl_peptidase_IV -LRB- CD26 -RRB- by the nonsteroidal anti-inflammatory drug diclofenac .
2173589	0	diclofenac	36,46	myeloperoxidase	15,30	diclofenac	myeloperoxidase	MESH:D004008	4353	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of myeloperoxidase with diclofenac .
2173589	1	diclofenac	110,120	myeloperoxidase	175,190	diclofenac	myeloperoxidase	MESH:D004008	4353	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|diclofenac diclofenac|acl|dihydroxyazobenzene dihydroxyazobenzene|nmod|END_ENTITY	Inhibition of the chlorinating activity of myeloperoxidase by diclofenac and oxidation of diclofenac to dihydroxyazobenzene by myeloperoxidase .
2173589	1	diclofenac	110,120	myeloperoxidase	91,106	diclofenac	myeloperoxidase	MESH:D004008	4353	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of the chlorinating activity of myeloperoxidase by diclofenac and oxidation of diclofenac to dihydroxyazobenzene by myeloperoxidase .
2173589	1	diclofenac	138,148	myeloperoxidase	175,190	diclofenac	myeloperoxidase	MESH:D004008	4353	Chemical	Gene	START_ENTITY|acl|dihydroxyazobenzene dihydroxyazobenzene|nmod|END_ENTITY	Inhibition of the chlorinating activity of myeloperoxidase by diclofenac and oxidation of diclofenac to dihydroxyazobenzene by myeloperoxidase .
2173589	1	diclofenac	138,148	myeloperoxidase	91,106	diclofenac	myeloperoxidase	MESH:D004008	4353	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of the chlorinating activity of myeloperoxidase by diclofenac and oxidation of diclofenac to dihydroxyazobenzene by myeloperoxidase .
19219624	0	diclofenac	77,87	peroxisome_proliferator-activated_receptor-gamma	25,73	diclofenac	peroxisome proliferator-activated receptor-gamma	MESH:D004008	19016(Tax:10090)	Chemical	Gene	results|amod|START_ENTITY END_ENTITY|nmod|results	Activation of macrophage peroxisome_proliferator-activated_receptor-gamma by diclofenac results in the induction of cyclooxygenase-2 protein and the synthesis of anti-inflammatory cytokines .
2975630	0	diclofenac	10,20	prolactin	56,65	diclofenac	prolactin	MESH:D004008	5617	Chemical	Gene	levels|amod|START_ENTITY levels|nmod|END_ENTITY	Effect of diclofenac on plasma levels of immunoreactive prolactin , follicle stimulating hormone , luteinizing hormone , thyrotropin , and beta-endorphin in humans .
9163575	0	diclofenac	32,42	substance_P	17,28	diclofenac	substance P	MESH:D004008	21333(Tax:10090)	Chemical	Gene	depletion|nmod|START_ENTITY depletion|nmod|END_ENTITY	The depletion of substance_P by diclofenac in the mouse .
3008321	0	diclofenac_sodium	10,27	N-formyl-methionyl-leucyl-phenylalanine	105,144	diclofenac sodium	N-formyl-methionyl-leucyl-phenylalanine	MESH:D004008	2357	Chemical	Gene	Effect|nmod|START_ENTITY Effect|acl|induced induced|nmod|END_ENTITY	Effect of diclofenac_sodium , tolfenamic_acid and indomethacin on the production of superoxide induced by N-formyl-methionyl-leucyl-phenylalanine in normal human polymorphonuclear leukocytes .
16480178	0	diclofenac_sodium	11,28	albumin	47,54	diclofenac sodium	albumin	MESH:D004008	213	Chemical	Gene	Binding|nmod|START_ENTITY END_ENTITY|nsubj|Binding	Binding of diclofenac_sodium with bovine serum albumin at different temperatures , pH and ionic strengths .
11786057	0	diclofenac_sodium	8,25	substance_P	40,51	diclofenac sodium	substance P	MESH:D004008	6863	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|content content|compound|END_ENTITY	Topical diclofenac_sodium decreases the substance_P content of tears .
19595748	0	dicofol	77,84	CYP1A1	13,19	dicofol	CYP1A1	MESH:D004010	24296(Tax:10116)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of CYP1A1 , 2B , 2E1 and 3A in rat liver by organochlorine pesticide dicofol .
16337670	0	dicofol	23,30	estrogen_receptor	46,63	dicofol	estrogen receptor	MESH:D004010	2099	Chemical	Gene	activity|nmod|START_ENTITY activity|nmod|END_ENTITY	Estrogenic activity of dicofol with the human estrogen_receptor : Isomer - and enantiomer-specific implications .
21613233	0	dicoumarol	37,47	NQO1	20,24	dicoumarol	NQO1	MESH:D001728	18104(Tax:10090)	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Inhibition of renal NQO1 activity by dicoumarol suppresses nitroreduction of aristolochic_acid_I and attenuates its nephrotoxicity .
12069105	0	dicumarol	10,19	DT-diaphorase	67,80	dicumarol	DT-diaphorase	MESH:D001728	24314(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|inhibitor inhibitor|compound|END_ENTITY	Effect of dicumarol , a Nad -LRB- P -RRB- h : quinone acceptor oxidoreductase 1 -LRB- DT-diaphorase -RRB- inhibitor on ubiquinone redox cycling in cultured rat hepatocytes .
14751451	0	dicumarol	88,97	DT-diaphorase	101,114	dicumarol	DT-diaphorase	MESH:D001728	24314(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Behavioral effects of manganese injected in the rat substantia nigra are potentiated by dicumarol , a DT-diaphorase inhibitor .
15111234	0	dicumarol	39,48	DT-diaphorase	15,28	dicumarol	DT-diaphorase	MESH:D001728	24314(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Effects of the DT-diaphorase inhibitor dicumarol on striatal monoamine levels in L-DOPA and L-deprenyl pre-treated rats .
9473494	8	dicumarol	1070,1079	iNOS	1057,1061	dicumarol	iNOS	MESH:D001728	24599(Tax:10116)	Chemical	Gene	mRNA|nmod|START_ENTITY mRNA|amod|END_ENTITY	The decrease of iNOS mRNA by dicumarol was abolished by sepiapterin .
7823768	0	dideoxynucleoside	91,108	interferon-a	61,73	dideoxynucleoside	interferon-a	null	111654(Tax:10090)	Chemical	Gene	therapy|compound|START_ENTITY END_ENTITY|nmod|therapy	Increased hematopoietic_toxicity following administration of interferon-a with combination dideoxynucleoside therapy -LRB- zidovudine plus ddI -RRB- administered in normal mice .
7606800	0	dideoxynucleoside	84,101	interleukin-2	19,32	dideoxynucleoside	interleukin-2	null	3558	Chemical	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Down-regulation of interleukin-2 receptor gene activation and protein expression by dideoxynucleoside analogs .
17143540	0	dideoxypetrosynol_A	84,103	cyclooxygenase-2_and_telomerase	14,45	dideoxypetrosynol A	cyclooxygenase-2 and telomerase	MESH:C499970	5743	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activities activities|amod|END_ENTITY	Inhibition of cyclooxygenase-2_and_telomerase activities in human leukemia cells by dideoxypetrosynol_A , a polyacetylene from the marine sponge Petrosia sp .
15770161	0	dieldrin	30,38	Heme_oxygenase-1	0,16	dieldrin	Heme oxygenase-1	MESH:D004026	3162	Chemical	Gene	induction|nmod|START_ENTITY induction|nsubj|END_ENTITY	Heme_oxygenase-1 induction by dieldrin in dopaminergic cells .
523978	0	diethanolamine	69,83	SMAC	58,62	diethanolamine	SMAC	MESH:C020283	56616	Chemical	Gene	START_ENTITY|nsubj|Determination Determination|nmod|END_ENTITY	Determination of alkaline phosphatase -LRB- EC 3.1.3.1 -RRB- on the SMAC using diethanolamine in a modified manifold .
2724368	0	diethyl_maleate	114,129	ornithine_decarboxylase	37,60	diethyl maleate	ornithine decarboxylase	MESH:C014476	24609(Tax:10116)	Chemical	Gene	enhancement|nmod|START_ENTITY forms|acl|enhancement sensitivity|nmod|forms forms|dep|sensitivity forms|nmod|END_ENTITY	Chloroform-induced multiple forms of ornithine_decarboxylase : differential sensitivity of forms to enhancement by diethyl_maleate and inhibition by ODC-antizyme .
3341033	0	diethyl_maleate	10,25	ornithine_decarboxylase	37,60	diethyl maleate	ornithine decarboxylase	MESH:C014476	24609(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of diethyl_maleate on hepatic ornithine_decarboxylase .
12065721	0	diethyl_maleate	113,128	xCT	64,67	diethyl maleate	xCT	MESH:C014476	26570(Tax:10090)	Chemical	Gene	treatment|amod|START_ENTITY END_ENTITY|nmod|treatment	Enhancement of L-cystine transport activity and its relation to xCT gene induction at the blood-brain barrier by diethyl_maleate treatment .
8135537	0	diethyl_pyrocarbonate	69,90	UGT1	59,63	diethyl pyrocarbonate	UGT1	MESH:D004047	54578	Chemical	Gene	modification|nmod|START_ENTITY modification|nmod|END_ENTITY	Chemical modification of human UDP-glucuronosyltransferase UGT1 * 6 by diethyl_pyrocarbonate : possible involvement of a histidine residue in the catalytic process .
2170502	0	diethyl_pyrocarbonate	80,101	glucose-6-phosphatase	42,63	diethyl pyrocarbonate	glucose-6-phosphatase	MESH:D004047	2538	Chemical	Gene	inactivation|nmod|START_ENTITY inactivation|amod|END_ENTITY	Image analysis for histochemical study of glucose-6-phosphatase inactivation by diethyl_pyrocarbonate in normal human liver .
8218384	0	diethyl_pyrocarbonate	90,111	tissue_inhibitor_of_metalloproteinases-1	25,65	diethyl pyrocarbonate	tissue inhibitor of metalloproteinases-1	MESH:D004047	7076	Chemical	Gene	modification|nmod|START_ENTITY modification|nmod|END_ENTITY	Chemical modification of tissue_inhibitor_of_metalloproteinases-1 and its inactivation by diethyl_pyrocarbonate .
3004501	0	diethylcarbamazine	117,135	5-lipoxygenase	153,167	diethylcarbamazine	5-lipoxygenase	MESH:D004049	25290(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Inhibition of the leukotriene synthetase of rat basophil leukemia cells by diethylcarbamazine , and synergism between diethylcarbamazine and piriprost , a 5-lipoxygenase inhibitor .
1519032	0	diethylcarbamazine	31,49	acetylcholinesterase	69,89	diethylcarbamazine	acetylcholinesterase	MESH:D004049	43	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	In vitro and in vivo effect of diethylcarbamazine on the activity of acetylcholinesterase from Wuchereria_bancrofti infected human serum .
17052849	0	diethyldithiocarbamate	96,118	BDNF	14,18	diethyldithiocarbamate	BDNF	MESH:D004050	24225(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|nsubj|Modulation Modulation|nmod|END_ENTITY	Modulation of BDNF and TrkB expression in rat hippocampus in response to acute neurotoxicity by diethyldithiocarbamate .
8393942	0	diethyldithiocarbamate	11,33	calmodulin	37,47	diethyldithiocarbamate	calmodulin	MESH:D004050	12314(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of diethyldithiocarbamate on calmodulin in neuroblastoma cells .
12593532	0	diethyldithiocarbamate	13,35	ecto-ATPase	55,66	diethyldithiocarbamate	ecto-ATPase	MESH:D004050	81613(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	Influence of diethyldithiocarbamate on the activity of ecto-ATPase in lymphocytes of rats : ex vivo studies .
1666936	0	diethyldithiocarbamate	11,33	interleukin_2	37,50	diethyldithiocarbamate	interleukin 2	MESH:D004050	3558	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|production production|amod|END_ENTITY	-LSB- Effect of diethyldithiocarbamate on interleukin_2 production of patients with oral_lichen_planus and its clinical therapeutic efficacy -RSB- .
20826547	0	diethyldithocarbamate	48,69	CYP2E1	38,44	diethyldithocarbamate	CYP2E1	null	1571	Chemical	Gene	inactivation|nmod|START_ENTITY inactivation|nmod|END_ENTITY	Mechanism-based inactivation of human CYP2E1 by diethyldithocarbamate .
18534133	0	diethylhexyl_phthalate	11,33	INSL3	44,49	diethylhexyl phthalate	INSL3	MESH:D004051	16336(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of diethylhexyl_phthalate -LRB- DEHP -RRB- on INSL3 mRNA expression by Leydig cells derived from mouse embryos and in newborn mice .
21880209	0	diethylhexyl_phthalate	30,52	P-glycoprotein	93,107	diethylhexyl phthalate	P-glycoprotein	MESH:D004051	5243	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	The effect of the plasticizer diethylhexyl_phthalate on transport activity and expression of P-glycoprotein in parental and doxo-resistant human sarcoma cell lines .
1287182	0	diethylmaleate	94,108	glutathione_S-transferase	33,58	diethylmaleate	glutathione S-transferase	MESH:C014476	58962(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Activation Activation|nmod|END_ENTITY	Activation of hepatic microsomal glutathione_S-transferase of rats by a glutathione depletor , diethylmaleate .
25585999	0	diethylnitrosamine	86,104	ADAM8	22,27	diethylnitrosamine	ADAM8	MESH:D004052	11501(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|role role|nmod|END_ENTITY	The important role of ADAM8 in the progression of hepatocellular_carcinoma induced by diethylnitrosamine in mice .
2844297	0	diethylnitrosamine	73,91	cytochrome_P-450	49,65	diethylnitrosamine	cytochrome P-450	MESH:D004052	25251(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY END_ENTITY|nmod|metabolism	-LSB- Decrease in the level and enzymatic activity of cytochrome_P-450 during diethylnitrosamine metabolism in vivo and in vitro -RSB- .
3014198	0	diethylnitrosamine	11,29	epidermal_growth_factor	85,108	diethylnitrosamine	epidermal growth factor	MESH:D004052	25313(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of diethylnitrosamine on hepatic receptor binding and autophosphorylation of epidermal_growth_factor and insulin in rats .
19794920	0	diethylnitrosamine	83,101	intercellular_adhesion_molecule-1	14,47	diethylnitrosamine	intercellular adhesion molecule-1	MESH:D004052	25464(Tax:10116)	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|Expression Expression|nmod|END_ENTITY	Expression of intercellular_adhesion_molecule-1 in the livers of rats treated with diethylnitrosamine .
24969048	0	diethylnitrosamine	70,88	neighbor_of_Punc_E11	14,34	diethylnitrosamine	neighbor of Punc E11	MESH:D004052	56741(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Expression Expression|nmod|END_ENTITY	Expression of neighbor_of_Punc_E11 in hepatocarcinogenesis induced by diethylnitrosamine .
222443	0	diethylnitrosamine	181,199	ornithine_decarboxylase	31,54	diethylnitrosamine	ornithine decarboxylase	MESH:D004052	4953	Chemical	Gene	administration|nmod|START_ENTITY activation|nmod|administration kinase|acl|activation induction|dep|kinase induction|nmod|END_ENTITY	Prolonged induction of hepatic ornithine_decarboxylase and its relation to cyclic_adenosine_3 ' :5 ' - monophosphate-dependent protein kinase activation after a single administration of diethylnitrosamine .
2888466	0	diethylnitrosamine	99,117	ornithine_decarboxylase	63,86	diethylnitrosamine	ornithine decarboxylase	MESH:D004052	24609(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Inhibitory effects of niacin and its analogues on induction of ornithine_decarboxylase activity by diethylnitrosamine in rat liver .
7273008	0	diethylnitrosamine	98,116	ornithine_decarboxylase	30,53	diethylnitrosamine	ornithine decarboxylase	MESH:D004052	24609(Tax:10116)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|phenobarbital phenobarbital|nmod|activity activity|amod|END_ENTITY	Induction by phenobarbital of ornithine_decarboxylase activity in rat liver after initiation with diethylnitrosamine .
3341778	0	diethylpyrocarbonate	105,125	cytochrome_b5	36,49	diethylpyrocarbonate	cytochrome b5	MESH:D004047	281110(Tax:9913)	Chemical	Gene	Modification|nmod|START_ENTITY Modification|nmod|END_ENTITY	Modification of trypsin-solubilized cytochrome_b5 , apocytochrome_b5 , and liposome-bound cytochrome_b5 by diethylpyrocarbonate .
8401407	0	diethylstilbestrol	46,64	DNA_topoisomerase_I	14,33	diethylstilbestrol	DNA topoisomerase I	MESH:D004054	100689046	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activity activity|compound|END_ENTITY	Inhibition of DNA_topoisomerase_I activity by diethylstilbestrol and its analogues .
11193187	0	diethylstilbestrol	20,38	c-fos	51,56	diethylstilbestrol	c-fos	MESH:D004054	14281(Tax:10090)	Chemical	Gene	exposure|compound|START_ENTITY exposure|nmod|END_ENTITY	Effects of neonatal diethylstilbestrol exposure on c-fos and c-jun protooncogene expression in the mouse uterus .
2436352	0	diethylstilbestrol	37,55	cytochrome_P-450	97,113	diethylstilbestrol	cytochrome P-450	MESH:D004054	4051	Chemical	Gene	Reduction|nmod|START_ENTITY Reduction|nmod|END_ENTITY	Reduction of irreversible binding of diethylstilbestrol in hamster renal cortex by inhibitors of cytochrome_P-450 .
23873838	0	diethylstilbestrol	87,105	cytochrome_P450scc	18,36	diethylstilbestrol	cytochrome P450scc	MESH:D004054	29680(Tax:10116)	Chemical	Gene	Downregulation|nmod|START_ENTITY Downregulation|nmod|END_ENTITY	Downregulation of cytochrome_P450scc as an initial adverse effect of adult exposure to diethylstilbestrol on testicular steroidogenesis .
19832683	0	diethylstilbestrol	118,136	estrogen_receptor_beta	15,37	diethylstilbestrol	estrogen receptor beta	MESH:D004054	13983(Tax:10090)	Chemical	Gene	exposed|nmod|START_ENTITY exposed|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of estrogen_receptor_beta in the induction of polyovular follicles in mouse ovaries exposed neonatally to diethylstilbestrol .
12354676	0	diethylstilbestrol	108,126	neuropsin	35,44	diethylstilbestrol	neuropsin	MESH:D004054	259277(Tax:10090)	Chemical	Gene	exposed|nmod|START_ENTITY exposed|nsubj|expression expression|nmod|END_ENTITY	Estrogen-independent expression of neuropsin , a serine_protease in the vagina of mice exposed neonatally to diethylstilbestrol .
2388902	0	diethylstilbestrol	22,40	prolactin_receptor	54,72	diethylstilbestrol	prolactin receptor	MESH:D004054	19116(Tax:10090)	Chemical	Gene	treatment|compound|START_ENTITY treatment|nmod|levels levels|compound|END_ENTITY	Influence of neonatal diethylstilbestrol treatment on prolactin_receptor levels in the mouse male reproductive system .
15469931	0	diethylstilbestrol	55,73	transthyretin	25,38	diethylstilbestrol	transthyretin	MESH:D004054	7276	Chemical	Gene	complex|nmod|START_ENTITY END_ENTITY|nmod|complex	The crystal structure of transthyretin in complex with diethylstilbestrol : a promising template for the design of amyloid inhibitors .
18243807	0	diethylstilbestrol	15,33	transthyretin	51,64	diethylstilbestrol	transthyretin	MESH:D004054	7276	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of diethylstilbestrol and ioxynil with transthyretin in chicken serum .
2461177	0	diethylstilbestrol_diphosphate	10,40	5_alpha-reductase	56,73	diethylstilbestrol diphosphate	5 alpha-reductase	MESH:C004955	6715	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of diethylstilbestrol_diphosphate on activity of 5_alpha-reductase in human prostate .
7109641	0	diethylstilbestrol_diphosphate	11,41	ribonuclease	62,74	diethylstilbestrol diphosphate	ribonuclease	MESH:C004955	853222(Tax:4932)	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of diethylstilbestrol_diphosphate on serum and tissue ribonuclease levels in prostatic_carcinoma .
21978460	0	dietylstilbestrol	64,81	alpha_2_macroglobulin	27,48	dietylstilbestrol	alpha 2 macroglobulin	null	418251(Tax:9031)	Chemical	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Differential expression of alpha_2_macroglobulin in response to dietylstilbestrol and in ovarian_carcinomas in chickens .
12807725	0	diferuloylmethane	10,27	COX-2	195,200	diferuloylmethane	COX-2	MESH:D003474	4513	Chemical	Gene	cigarette|compound|START_ENTITY cigarette|dep|correlation correlation|nmod|suppression suppression|nmod|END_ENTITY	Curcumin -LRB- diferuloylmethane -RRB- down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells : correlation with suppression of COX-2 , MMP-9 and cyclin_D1 .
12807725	0	diferuloylmethane	10,27	NF-kappaB	68,77	diferuloylmethane	NF-kappaB	MESH:D003474	4790	Chemical	Gene	cigarette|compound|START_ENTITY cigarette|acl|smoke-induced smoke-induced|dobj|activation activation|amod|END_ENTITY	Curcumin -LRB- diferuloylmethane -RRB- down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells : correlation with suppression of COX-2 , MMP-9 and cyclin_D1 .
17107884	0	diflunisal	20,30	transthyretin	42,55	diflunisal	transthyretin	MESH:D004061	7276	Chemical	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	Orally administered diflunisal stabilizes transthyretin against dissociation required for amyloidogenesis .
1764115	1	diflunisal_acyl_glucuronide	67,94	albumin	128,135	diflunisal acyl glucuronide	albumin	MESH:C041944	213	Chemical	Gene	Interaction|nmod|START_ENTITY END_ENTITY|nsubj|Interaction	Interaction of diflunisal_acyl_glucuronide and its isomers with human serum albumin in vitro .
1299379	0	difluorodeoxycytidine	74,95	deoxycytidine_kinase	10,30	difluorodeoxycytidine	deoxycytidine kinase	null	1633	Chemical	Gene	cells|nmod|START_ENTITY activity|nmod|cells activity|amod|END_ENTITY	Increased deoxycytidine_kinase activity in cancer cells and inhibition by difluorodeoxycytidine .
11312928	0	difluoromethylene_ketones	89,114	chymase	144,151	difluoromethylene ketones	chymase	null	1215	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Synthesis , structure-activity relationships , and pharmacokinetic profiles of nonpeptidic difluoromethylene_ketones as novel inhibitors of human chymase .
11888902	0	difluoromethylornithine	36,59	Xpa	100,103	difluoromethylornithine	Xpa	null	22590(Tax:10090)	Chemical	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Suppression of UV carcinogenesis by difluoromethylornithine in nucleotide excision repair-deficient Xpa knockout mice .
3141046	0	difluoromethylornithine	17,40	alpha_2a-interferon	73,92	difluoromethylornithine	alpha 2a-interferon	null	3440	Chemical	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	Phase I study of difluoromethylornithine in combination with recombinant alpha_2a-interferon .
8441821	0	difluoromethylornithine	10,33	atrial_natriuretic_peptide	37,63	difluoromethylornithine	atrial natriuretic peptide	null	24602(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of difluoromethylornithine on atrial_natriuretic_peptide in rat atria .
1852267	0	difluoromethylornithine	24,47	ornithine_decarboxylase	90,113	difluoromethylornithine	ornithine decarboxylase	null	4953	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Differential effects of difluoromethylornithine on basal and induced activity of cerebral ornithine_decarboxylase and mRNA .
16004263	0	digipramine	68,79	thyrotropin-releasing_hormone	11,40	digipramine	thyrotropin-releasing hormone	MESH:C090581	25569(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	-LSB- Effect of thyrotropin-releasing_hormone and its synthetic analogue digipramine on certain hemostatic indices in vitro and in vivo -RSB- .
4404754	0	digitoxigenin	16,29	cytochrome_P-450	51,67	digitoxigenin	cytochrome P-450	MESH:D004073	4051	Chemical	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of digitoxigenin and digoxigenin with cytochrome_P-450 .
8097706	0	digitoxigenin_monodigitoxoside	44,74	UDP-glucuronosyltransferase	0,27	digitoxigenin monodigitoxoside	UDP-glucuronosyltransferase	MESH:C035486	54657	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	UDP-glucuronosyltransferase activity toward digitoxigenin_monodigitoxoside in human liver microsomes .
2171043	0	diglyceride	25,36	Interleukin-1	0,13	diglyceride	Interleukin-1	CHEBI:18035	3552	Chemical	Gene	accumulation|amod|START_ENTITY stimulates|dobj|accumulation stimulates|nsubj|END_ENTITY	Interleukin-1 stimulates diglyceride accumulation in the absence of protein_kinase_C activation .
3796224	0	diglyceride	24,35	lipase	36,42	diglyceride	lipase	CHEBI:18035	291437(Tax:10116)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	Effects of RHC_80267 , a diglyceride lipase inhibitor , on prolactin secretion and calcium uptake in GH3 pituitary cells .
12134942	0	digoxin	61,68	Organic_anion_transporter	0,25	digoxin	Organic anion transporter	MESH:D004077	140668(Tax:10116)	Chemical	Gene	interaction|nmod|START_ENTITY interaction|amod|END_ENTITY	Organic_anion_transporter oatp2-mediated interaction between digoxin and amiodarone in the rat liver .
12189368	0	digoxin	75,82	P-glycoprotein	99,113	digoxin	P-glycoprotein	MESH:D004077	5243	Chemical	Gene	START_ENTITY|appos|substrate substrate|nmod|END_ENTITY	Role of human MDR1 gene polymorphism in bioavailability and interaction of digoxin , a substrate of P-glycoprotein .
12820149	0	digoxin	68,75	P-glycoprotein	8,22	digoxin	P-glycoprotein	MESH:D004077	287115(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of P-glycoprotein in pharmacokinetics and drug interactions of digoxin and beta-methyldigoxin in rats .
18812023	0	digoxin	46,53	P-glycoprotein	57,71	digoxin	P-glycoprotein	MESH:D004077	67078(Tax:10090)	Chemical	Gene	START_ENTITY|appos|substrate substrate|amod|END_ENTITY	Lack of difference in pulmonary absorption of digoxin , a P-glycoprotein substrate , in mdr1a-deficient and mdr1a-competent mice .
7850462	0	dihydrexidine	11,24	dopamine_D-1_receptor	33,54	dihydrexidine	dopamine D-1 receptor	MESH:C061532	1812	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Effects of dihydrexidine , a full dopamine_D-1_receptor agonist , on delayed response performance in chronic_low_dose MPTP-treated monkeys .
16575553	0	dihydrexidine	73,86	dopamine_D1_receptor	11,31	dihydrexidine	dopamine D1 receptor	MESH:C061532	1812	Chemical	Gene	trained|nmod|START_ENTITY trained|nsubj|Effects Effects|nmod|agonists agonists|amod|END_ENTITY	Effects of dopamine_D1_receptor agonists in rats trained to discriminate dihydrexidine .
9844789	0	dihydrexidine	49,62	dopamine_D1_receptor	20,40	dihydrexidine	dopamine D1 receptor	MESH:C061532	1812	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|agonist agonist|amod|END_ENTITY	Effects of the full dopamine_D1_receptor agonist dihydrexidine in Parkinson 's _ disease .
23062711	0	dihydro-pyrazolyl-thiazolinone	59,89	COX-2	115,120	dihydro-pyrazolyl-thiazolinone	COX-2	null	5743	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|inhibitors inhibitors|compound|END_ENTITY	Synthesis , biological evaluation and molecular modeling of dihydro-pyrazolyl-thiazolinone derivatives as potential COX-2 inhibitors .
2224840	0	dihydroambazone	92,107	tumor_necrosis_factor_alpha	50,77	dihydroambazone	tumor necrosis factor alpha	MESH:C058853	7124	Chemical	Gene	combined|nmod|START_ENTITY combined|nsubj|effect effect|nmod|END_ENTITY	Synergistic cytotoxic effect of human recombinant tumor_necrosis_factor_alpha combined with dihydroambazone .
20688127	0	dihydroartemisinin	22,40	CD34	50,54	dihydroartemisinin	CD34	MESH:C039060	947	Chemical	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Selective toxicity of dihydroartemisinin on human CD34 + erythroid cell differentiation .
24681255	0	dihydroartemisinin	48,66	DJ-1	0,4	dihydroartemisinin	DJ-1	MESH:C039060	11315	Chemical	Gene	mediates|xcomp|START_ENTITY mediates|nsubj|END_ENTITY	DJ-1 mediates the resistance of cancer cells to dihydroartemisinin through reactive oxygen species removal .
22553631	0	dihydroartemisinin	8,26	ERK1/2	93,99	dihydroartemisinin	ERK1/2	MESH:C039060	50689;116590	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Topical dihydroartemisinin inhibits suture-induced neovascularization in rat corneas through ERK1/2 and p38 pathways .
23429041	0	dihydroartemisinin	21,39	cyclooxygenase-2	70,86	dihydroartemisinin	cyclooxygenase-2	MESH:C039060	19225(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|amod|END_ENTITY	Inhibitory effect of dihydroartemisinin against phorbol_ester-induced cyclooxygenase-2 expression in macrophages .
18325342	0	dihydroartemisinin	40,58	fortilin	6,14	dihydroartemisinin	fortilin	MESH:C039060	7178	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Human fortilin is a molecular target of dihydroartemisinin .
24765140	0	dihydroartemisinin	65,83	urokinase-type_plasminogen_activator	14,50	dihydroartemisinin	urokinase-type plasminogen activator	MESH:C039060	5328	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|expression expression|amod|END_ENTITY	Inhibition of urokinase-type_plasminogen_activator expression by dihydroartemisinin in breast_cancer cells .
24755425	0	dihydrobenzofuran	49,66	GPR119	94,100	dihydrobenzofuran	GPR119	null	139760	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	Synthesis and structure-activity relationship of dihydrobenzofuran derivatives as novel human GPR119 agonists .
25921859	0	dihydrochalcone_glycosides	55,81	Dipeptidyl_peptidase-IV	0,23	dihydrochalcone glycosides	Dipeptidyl peptidase-IV	null	13482(Tax:10090)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Dipeptidyl_peptidase-IV inhibitory activity of dimeric dihydrochalcone_glycosides from flowers of Helichrysum arenarium .
11453732	0	dihydrodiol	25,36	AKR1C9	52,58	dihydrodiol	AKR1C9	MESH:C507866	191574(Tax:10116)	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	Stable expression of rat dihydrodiol dehydrogenase -LRB- AKR1C9 -RRB- in human breast MCF-7 cells results in the formation of PAH-o-quinones and enzyme mediated cell death .
18251511	0	dihydrodiol	117,128	AKR1C9	144,150	dihydrodiol	AKR1C9	MESH:C507866	191574(Tax:10116)	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	Fjord-region benzo -LSB- g -RSB- chrysene-11 ,12 - dihydrodiol and benzo -LSB- c -RSB- phenanthrene-3 ,4 - dihydrodiol as substrates for rat liver dihydrodiol dehydrogenase -LRB- AKR1C9 -RRB- : structural basis for stereochemical preference .
15193156	0	dihydrofolate	61,74	DHFR	86,90	dihydrofolate	DHFR	MESH:C010920	100359209(Tax:9986)	Chemical	Gene	reductase|amod|START_ENTITY reductase|appos|END_ENTITY	Homology building as a means to define antigenic epitopes on dihydrofolate reductase -LRB- DHFR -RRB- from Plasmodium_falciparum .
2323224	0	dihydrofolate	22,35	DHFR	37,41	dihydrofolate	DHFR	MESH:C010920	24312(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|genes genes|appos|END_ENTITY	Assignment of two rat dihydrofolate -LRB- DHFR -RRB- genes to chromosomes 2 and 4 .
2401371	0	dihydrofolate	94,107	DHFR	26,30	dihydrofolate	DHFR	MESH:C010920	1719	Chemical	Gene	mutants|nmod|START_ENTITY using|dobj|mutants cells|acl|using cells|amod|END_ENTITY	Transfection of DHFR - and DHFR + mammalian cells using methotrexate-resistant mutants of mouse dihydrofolate reductase .
8246174	0	dihydrofolate	47,60	DHFR	111,115	dihydrofolate	DHFR	MESH:C010920	13361(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY reductase|nsubj|expression reductase|xcomp|activity activity|nmod|mice mice|dep|transduced transduced|nmod|retrovirus retrovirus|amod|END_ENTITY	Selective expression of methotrexate-resistant dihydrofolate reductase -LRB- DHFR -RRB- activity in mice transduced with DHFR retrovirus and administered methotrexate .
8246174	0	dihydrofolate	47,60	DHFR	72,76	dihydrofolate	DHFR	MESH:C010920	13361(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY reductase|nsubj|expression reductase|xcomp|activity activity|dep|END_ENTITY	Selective expression of methotrexate-resistant dihydrofolate reductase -LRB- DHFR -RRB- activity in mice transduced with DHFR retrovirus and administered methotrexate .
25504244	0	dihydrofolate	27,40	dhfr	53,57	dihydrofolate	dhfr	MESH:C010920	13906554	Chemical	Gene	reductase|amod|START_ENTITY reductase|appos|END_ENTITY	-LSB- Gene polymorphisms in the dihydrofolate reductase -LRB- dhfr -RRB- and dihydropteroate synthase -LRB- dhps -RRB- genes and structural modelling of the dhps gene in Colombian isolates of Toxoplasma_gondii -RSB- .
12852950	0	dihydrofolate	124,137	dihydrofolate_reductase	74,97	dihydrofolate	dihydrofolate reductase	MESH:C010920	13906554	Chemical	Gene	competitive|nmod|START_ENTITY inhibitors|acl:relcl|competitive inhibitors|nmod|END_ENTITY	High throughput screening identifies novel inhibitors of Escherichia_coli dihydrofolate_reductase that are competitive with dihydrofolate .
12862454	0	dihydrofolate	55,68	dihydrofolate_reductase	4,27	dihydrofolate	dihydrofolate reductase	MESH:C010920	13906554	Chemical	Gene	protonation|nmod|START_ENTITY facilitates|nsubj|protonation facilitates|dep|END_ENTITY	How dihydrofolate_reductase facilitates protonation of dihydrofolate .
478995	0	dihydrofolate	45,58	dihydrofolate_reductase	74,97	dihydrofolate	dihydrofolate reductase	MESH:C010920	1719	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	The kinetics of the histochemical method for dihydrofolate dehydrogenase -LRB- dihydrofolate_reductase -RRB- .
6344924	0	dihydrofolate	36,49	dihydrofolate_reductase	77,100	dihydrofolate	dihydrofolate reductase	MESH:C010920	13906554	Chemical	Gene	the|nmod|START_ENTITY pH-dependence|nmod|the analogues|nsubj|pH-dependence analogues|xcomp|END_ENTITY	The pH-dependence of the binding of dihydrofolate and substrate analogues to dihydrofolate_reductase from Escherichia_coli .
6433972	0	dihydrofolate	15,28	dihydrofolate_reductase	32,55	dihydrofolate	dihydrofolate reductase	MESH:C010920	508809(Tax:9913)	Chemical	Gene	Dismutation|nmod|START_ENTITY Dismutation|nmod|END_ENTITY	Dismutation of dihydrofolate by dihydrofolate_reductase .
791943	0	dihydrofolate	108,121	dihydrofolate_reductase	43,66	dihydrofolate	dihydrofolate reductase	MESH:C010920	13906554	Chemical	Gene	analogs|nmod|START_ENTITY affinities|nmod|analogs END_ENTITY|nmod|affinities	Interconvertible forms of Escherichia_coli dihydrofolate_reductase with different affinities for analogs of dihydrofolate .
8003467	0	dihydrofolate	56,69	dihydrofolate_reductase	79,102	dihydrofolate	dihydrofolate reductase	MESH:C010920	13906554	Chemical	Gene	Determination|nmod|START_ENTITY Determination|acl|bound bound|xcomp|END_ENTITY	Determination by Raman spectroscopy of the pKa of N5 of dihydrofolate bound to dihydrofolate_reductase : mechanistic implications .
2116172	0	dihydrofolate	20,33	reductase	34,43	dihydrofolate	reductase	MESH:C010920	42284(Tax:7227)	Chemical	Gene	purification|nmod|START_ENTITY END_ENTITY|nsubj|purification	The purification of dihydrofolate reductase from Drosophila_melanogaster .
23343619	0	dihydroisosteviol	62,79	AMP-activated_protein_kinase	14,42	dihydroisosteviol	AMP-activated protein kinase	null	5563	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of AMP-activated_protein_kinase by a plant-derived dihydroisosteviol in human intestinal epithelial cell .
10094940	0	dihydrolipoamide	60,76	E3BP	108,112	dihydrolipoamide	E3BP	MESH:C007409	8050	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Autoepitope mapping and reactivity of autoantibodies to the dihydrolipoamide dehydrogenase-binding protein -LRB- E3BP -RRB- and the glycine cleavage proteins in primary_biliary_cirrhosis .
7663427	0	dihydrolipoate	55,69	NF-kappa_B	20,30	dihydrolipoate	NF-kappa B	MESH:C015144	4790	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Redox regulation of NF-kappa_B DNA binding activity by dihydrolipoate .
15870844	0	dihydrolipoic_acid	59,77	gelatinase_B	14,26	dihydrolipoic acid	gelatinase B	MESH:C015144	4318	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of gelatinase_B -LRB- matrix_metalloproteinase-9 -RRB- by dihydrolipoic_acid .
12467981	0	dihydrolipoyl	8,21	E3	37,39	dihydrolipoyl	E3	null	290032(Tax:10116)	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	Role of dihydrolipoyl dehydrogenase -LRB- E3 -RRB- and a novel E3-binding protein in the NADH sensitivity of the pyruvate_dehydrogenase_complex from anaerobic mitochondria of the parasitic nematode , Ascaris_suum .
17369345	0	dihydroorotate	31,45	DHODH	131,136	dihydroorotate	DHODH	MESH:C004768	1723	Chemical	Gene	dehydrogenase|compound|START_ENTITY expression|nmod|dehydrogenase allows|nsubj|expression allows|dobj|validation validation|nmod|inhibitors inhibitors|amod|END_ENTITY	Functional expression of human dihydroorotate dehydrogenase -LRB- DHODH -RRB- in pyr4 mutants of ustilago_maydis allows target validation of DHODH inhibitors in vivo .
17369345	0	dihydroorotate	31,45	DHODH	61,66	dihydroorotate	DHODH	MESH:C004768	1723	Chemical	Gene	dehydrogenase|compound|START_ENTITY dehydrogenase|appos|END_ENTITY	Functional expression of human dihydroorotate dehydrogenase -LRB- DHODH -RRB- in pyr4 mutants of ustilago_maydis allows target validation of DHODH inhibitors in vivo .
23714018	0	dihydroorotate	105,119	hDHODH	135,141	dihydroorotate	hDHODH	MESH:C004768	1723	Chemical	Gene	dehydrogenase|compound|START_ENTITY dehydrogenase|appos|END_ENTITY	Development of docking-based 3D QSAR models for the design of substituted quinoline derivatives as human dihydroorotate dehydrogenase -LRB- hDHODH -RRB- inhibitors .
6087880	0	dihydroorotates	36,51	dihydroorotate_oxidase	59,81	dihydroorotates	dihydroorotate oxidase	null	1723	Chemical	Gene	studies|nmod|START_ENTITY studies|nmod|END_ENTITY	Mechanistic studies with deuterated dihydroorotates on the dihydroorotate_oxidase from Crithidia fasciculata .
10839989	0	dihydropteridine	100,116	phenylalanine_hydroxylase	73,98	dihydropteridine	phenylalanine hydroxylase	CHEBI:30156	24616(Tax:10116)	Chemical	Gene	reductase|amod|START_ENTITY reductase|amod|END_ENTITY	Contrasting effects of N5-substituted tetrahydrobiopterin derivatives on phenylalanine_hydroxylase , dihydropteridine reductase and nitric_oxide synthase .
23668792	0	dihydropteridine	67,83	transforming_growth_factor_beta_1	14,47	dihydropteridine	transforming growth factor beta 1	CHEBI:30156	7040	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of transforming_growth_factor_beta_1 gene expression by dihydropteridine reductase in kidney 293T cells .
1745247	0	dihydropterin	93,106	little_isoxanthopterin	44,66	dihydropterin	little isoxanthopterin	CHEBI:38797	5656944	Chemical	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Genetic and biochemical characterization of little_isoxanthopterin -LRB- lix -RRB- , a gene controlling dihydropterin oxidase activity in Drosophila_melanogaster .
25504244	0	dihydropteroate	64,79	dhps	91,95	dihydropteroate	dhps	MESH:C000978	13906535	Chemical	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	-LSB- Gene polymorphisms in the dihydrofolate reductase -LRB- dhfr -RRB- and dihydropteroate synthase -LRB- dhps -RRB- genes and structural modelling of the dhps gene in Colombian isolates of Toxoplasma_gondii -RSB- .
22343406	0	dihydropyrazole	19,34	Eg5	105,108	dihydropyrazole	Eg5	null	3832	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|inhibitors inhibitors|nmod|END_ENTITY	3D-QSAR studies of dihydropyrazole and dihydropyrrole derivatives as inhibitors of human mitotic kinesin Eg5 based on molecular docking .
25866240	0	dihydropyrazole_sulfonamide	67,94	COX-1	120,125	dihydropyrazole sulfonamide	COX-1	null	4512	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Design , synthesis , biological evaluation and molecular modeling of dihydropyrazole_sulfonamide derivatives as potential COX-1 / COX-2 inhibitors .
1816763	0	dihydropyridine	23,38	CD349	10,15	dihydropyridine	CD349	MESH:C038806	8326	Chemical	Gene	antagonist|amod|START_ENTITY END_ENTITY|appos|antagonist	Effect of CD349 , a new dihydropyridine derivative Ca2 + antagonist , on the voltage-dependent Ca2 + currents in isolated mammalian brain neurons .
9744921	0	dihydropyridine	62,77	ICa	93,96	dihydropyridine	ICa	MESH:C038806	71775(Tax:10090)	Chemical	Gene	sensitivity|amod|START_ENTITY sensitivity|nmod|END_ENTITY	Passive transfer of Lambert-Eaton_myasthenic_syndrome induces dihydropyridine sensitivity of ICa in mouse motor nerve terminals .
21530277	0	dihydropyridine	56,71	MRP1	93,97	dihydropyridine	MRP1	MESH:C038806	4363	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	Molecular docking studies and in vitro screening of new dihydropyridine derivatives as human MRP1 inhibitors .
10648640	0	dihydropyridine	67,82	ZG-16p	43,49	dihydropyridine	ZG-16p	MESH:C038806	171449(Tax:10116)	Chemical	Gene	protein|amod|START_ENTITY END_ENTITY|appos|protein	Photoaffinity labeling and purification of ZG-16p , a high-affinity dihydropyridine binding protein of rat pancreatic zymogen granule membranes that regulates a K -LRB- + -RRB- - selective conductance .
9251797	0	dihydropyridine	89,104	beta_1	114,120	dihydropyridine	beta 1	MESH:C038806	15129(Tax:10090)	Chemical	Gene	subunit|amod|START_ENTITY subunit|amod|END_ENTITY	Recovery of Ca2 + current , charge movements , and Ca2 + transients in myotubes_deficient in dihydropyridine receptor beta_1 subunit transfected with beta_1 cDNA .
9525869	0	dihydropyridine	153,168	skeletal_muscle_ryanodine_receptor	32,66	dihydropyridine	skeletal muscle ryanodine receptor	MESH:C038806	6261	Chemical	Gene	receptor|compound|START_ENTITY interacts|nmod|receptor interacts|nsubj|sequence sequence|nmod|END_ENTITY	A 37-amino_acid sequence in the skeletal_muscle_ryanodine_receptor interacts with the cytoplasmic loop between domains II and III in the skeletal muscle dihydropyridine receptor .
9792715	0	dihydropyridine	95,110	skeletal_muscle_ryanodine_receptor	153,187	dihydropyridine	skeletal muscle ryanodine receptor	MESH:C038806	6261	Chemical	Gene	START_ENTITY|nmod|site site|nmod|END_ENTITY	The cytoplasmic loops between domains II and III and domains III and IV in the skeletal muscle dihydropyridine receptor bind to a contiguous site in the skeletal_muscle_ryanodine_receptor .
2223055	0	dihydropyridine_202791	58,80	insulin	84,91	dihydropyridine 202791	insulin	null	3630	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	Effects of Ca2 + channel agonist-antagonist enantiomers of dihydropyridine_202791 on insulin release , 45Ca uptake and electrical activity in isolated pancreatic islets .
2593383	0	dihydropyridine_calcium	26,49	CV-4093	11,18	dihydropyridine calcium	CV-4093	null	2548914(Tax:243365)	Chemical	Gene	blocker|compound|START_ENTITY END_ENTITY|appos|blocker	Effects of CV-4093 , a new dihydropyridine_calcium channel blocker , on renal hemodynamics and function in stroke-prone spontaneously hypertensive rats -LRB- SHRSP -RRB- .
2167684	0	dihydropyridine_calcium	19,42	calmodulin	68,78	dihydropyridine calcium	calmodulin	null	808	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of the dihydropyridine_calcium antagonist , CD-349 , with calmodulin .
1713849	0	dihydropyridines	27,43	Ca2	0,3	dihydropyridines	Ca2	MESH:D004095	101094903	Chemical	Gene	modulation|nmod|START_ENTITY modulation|amod|END_ENTITY	Ca2 + channel modulation by dihydropyridines modifies sufentanil-induced respiratory_depression in cats .
2363897	0	dihydropyridines	50,66	Parathyroid_hormone	0,19	dihydropyridines	Parathyroid hormone	MESH:D004095	5741	Chemical	Gene	effects|nmod|START_ENTITY effects|amod|END_ENTITY	Parathyroid_hormone and cardiovascular effects of dihydropyridines in chronic_renal_failure .
16556484	0	dihydropyrimidine	86,103	DPYD	124,128	dihydropyrimidine	DPYD	null	1806	Chemical	Gene	dehydrogenase|amod|START_ENTITY gene|amod|dehydrogenase gene|appos|END_ENTITY	FRA1E common fragile site breaks map within a 370kilobase pair region and disrupt the dihydropyrimidine dehydrogenase gene -LRB- DPYD -RRB- .
17699726	0	dihydropyrimidine	14,31	IFN-alpha	60,69	dihydropyrimidine	IFN-alpha	null	3439	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Alteration of dihydropyrimidine dehydrogenase expression by IFN-alpha affects the antiproliferative effects of 5-fluorouracil in human hepatocellular_carcinoma cells .
14698158	0	dihydroquinazolinone	72,92	p38	93,96	dihydroquinazolinone	p38	null	26416(Tax:10090)	Chemical	Gene	kinase|amod|START_ENTITY kinase|amod|END_ENTITY	A novel Pd-catalyzed cyclization reaction of ureas for the synthesis of dihydroquinazolinone p38 kinase inhibitors .
22454147	0	dihydrotestosterone	19,38	AMPK	0,4	dihydrotestosterone	AMPK	MESH:D013196	78975(Tax:10116)	Chemical	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	AMPK activation by dihydrotestosterone reduces FSH-stimulated cell proliferation in rat granulosa cells by inhibiting ERK signaling pathway .
20677326	0	dihydrotestosterone	67,86	Androgen_receptor	0,17	dihydrotestosterone	Androgen receptor	MESH:D013196	367	Chemical	Gene	doses|nmod|START_ENTITY induced|nmod|doses induced|nsubj|signaling signaling|compound|END_ENTITY	Androgen_receptor signaling induced by supraphysiological doses of dihydrotestosterone in human peripheral blood lymphocytes .
12629413	0	dihydrotestosterone	34,53	Bcl-2	14,19	dihydrotestosterone	Bcl-2	MESH:D013196	596	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of Bcl-2 expression by dihydrotestosterone in hormone sensitive LNCaP-FGC prostate_cancer cells .
10875240	0	dihydrotestosterone	61,80	Insulin-like_growth_factor_binding_protein-3	0,44	dihydrotestosterone	Insulin-like growth factor binding protein-3	MESH:D013196	3486	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Insulin-like_growth_factor_binding_protein-3 is regulated by dihydrotestosterone and stimulates deoxyribonucleic acid synthesis and cell proliferation in LNCaP_prostate_carcinoma cells .
7409905	0	dihydrotestosterone	22,41	acetylcholinesterase	49,69	dihydrotestosterone	acetylcholinesterase	MESH:D013196	83817(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Stimulatory effect of dihydrotestosterone on the acetylcholinesterase activity of rat adenohypophysis .
2935156	0	dihydrotestosterone	74,93	alcohol_dehydrogenase	14,35	dihydrotestosterone	alcohol dehydrogenase	MESH:D013196	78959(Tax:10116)	Chemical	Gene	hepatocyte|nmod|START_ENTITY hepatocyte|nsubj|Depression Depression|nmod|activity activity|amod|END_ENTITY	Depression of alcohol_dehydrogenase activity in rat hepatocyte culture by dihydrotestosterone .
7042506	0	dihydrotestosterone	10,29	alcohol_dehydrogenase	43,64	dihydrotestosterone	alcohol dehydrogenase	MESH:D013196	78959(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of dihydrotestosterone on rat liver alcohol_dehydrogenase activity .
9425936	0	dihydrotestosterone	10,29	alcohol_dehydrogenase	45,66	dihydrotestosterone	alcohol dehydrogenase	MESH:D013196	78959(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of dihydrotestosterone on turnover of alcohol_dehydrogenase in rat hepatocyte culture .
1698906	0	dihydrotestosterone	10,29	alpha_2u-globulin	57,74	dihydrotestosterone	alpha 2u-globulin	MESH:D013196	298111(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|concentrations concentrations|nmod|END_ENTITY	Effect of dihydrotestosterone on serum concentrations of alpha_2u-globulin and on spermatogenesis in melatonin-treated rats .
11320241	0	dihydrotestosterone	139,158	androgen_receptor	65,82	dihydrotestosterone	androgen receptor	MESH:D013196	367	Chemical	Gene	complexed|nmod|START_ENTITY complexed|nsubj|structures structures|nmod|ligand-binding_domains ligand-binding_domains|nmod|END_ENTITY	Crystallographic structures of the ligand-binding_domains of the androgen_receptor and its T877A mutant complexed with the natural agonist dihydrotestosterone .
19737972	0	dihydrotestosterone	101,120	androgen_receptor	14,31	dihydrotestosterone	androgen receptor	MESH:D013196	367	Chemical	Gene	increasing|advcl|START_ENTITY enhances|advcl|increasing enhances|dobj|function function|compound|END_ENTITY	Prx1 enhances androgen_receptor function in prostate_cancer cells by increasing receptor affinity to dihydrotestosterone .
2298157	0	dihydrotestosterone	92,111	androgen_receptor	61,78	dihydrotestosterone	androgen receptor	MESH:D013196	367	Chemical	Gene	similarly|xcomp|START_ENTITY END_ENTITY|amod|similarly	Testosterone at high concentrations interacts with the human androgen_receptor similarly to dihydrotestosterone .
24239616	0	dihydrotestosterone	65,84	androgen_receptor	34,51	dihydrotestosterone	androgen receptor	MESH:D013196	367	Chemical	Gene	\|amod|START_ENTITY responses|nmod|\ responses|compound|END_ENTITY	Molecular and structural basis of androgen_receptor responses to dihydrotestosterone , medroxyprogesterone_acetate and / \ -LRB- 4 -RRB- - tibolone .
25511993	0	dihydrotestosterone	28,47	androgen_receptor	112,129	dihydrotestosterone	androgen receptor	MESH:D013196	24208(Tax:10116)	Chemical	Gene	spines|nmod|START_ENTITY increase|nmod|spines increase|dep|Dependence Dependence|nmod|END_ENTITY	Rapid increase of spines by dihydrotestosterone and testosterone in hippocampal neurons : Dependence on synaptic androgen_receptor and kinase networks .
2917511	0	dihydrotestosterone	64,83	androgen_receptor	132,149	dihydrotestosterone	androgen receptor	MESH:D013196	367	Chemical	Gene	beta-bromoacetate|compound|START_ENTITY labeled|nmod|beta-bromoacetate protein|acl|labeled characterization|nmod|protein characterization|dep|comparison comparison|nmod|END_ENTITY	Biochemical characterization of the protein affinity labeled by dihydrotestosterone 17 beta-bromoacetate : comparison with the human androgen_receptor .
6249575	0	dihydrotestosterone	19,38	androgen_receptor	54,71	dihydrotestosterone	androgen receptor	MESH:D013196	24208(Tax:10116)	Chemical	Gene	START_ENTITY|xcomp|binding binding|nmod|END_ENTITY	Marihuana inhibits dihydrotestosterone binding to the androgen_receptor .
7132347	0	dihydrotestosterone	147,166	androgen_receptor	54,71	dihydrotestosterone	androgen receptor	MESH:D013196	24208(Tax:10116)	Chemical	Gene	steroids|nmod|START_ENTITY competition|nmod|steroids properties|dep|competition properties|nmod|END_ENTITY	Steroid-binding properties of the rat seminal vesicle androgen_receptor : short-term and long-term competition of various steroids with radioactive dihydrotestosterone .
7981221	0	dihydrotestosterone	93,112	androgen_receptor	10,27	dihydrotestosterone	androgen receptor	MESH:D013196	11835(Tax:10090)	Chemical	Gene	regulated|nmod|START_ENTITY promoter|acl:relcl|regulated contains|dobj|promoter contains|nsubj|gene gene|compound|END_ENTITY	The mouse androgen_receptor gene contains a second functional promoter which is regulated by dihydrotestosterone .
9062878	0	dihydrotestosterone	65,84	androgen_receptor	17,34	dihydrotestosterone	androgen receptor	MESH:D013196	367	Chemical	Gene	Heterogeneity|dep|START_ENTITY Heterogeneity|nmod|levels levels|compound|END_ENTITY	Heterogeneity in androgen_receptor levels and growth response to dihydrotestosterone in sublines derived from human hepatocellular_carcinoma line -LRB- KYN-1 -RRB- .
9834454	0	dihydrotestosterone	79,98	androgen_receptor	13,30	dihydrotestosterone	androgen receptor	MESH:D013196	367	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Evidence for androgen_receptor gene expression and growth inhibitory effect of dihydrotestosterone on human adrenocortical cells .
10718935	0	dihydrotestosterone	24,43	growth_hormone	47,61	dihydrotestosterone	growth hormone	MESH:D013196	81668(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	Masculinizing effect of dihydrotestosterone on growth_hormone secretion is inhibited in ovariectomized rats with anterolateral deafferentation of the medial basal hypothalamus or in intact female rats .
12065891	0	dihydrotestosterone	18,37	growth_hormone	98,112	dihydrotestosterone	growth hormone	MESH:D013196	81668(Tax:10116)	Chemical	Gene	Microinjection|nmod|START_ENTITY produces|nsubj|Microinjection produces|dobj|pattern pattern|nmod|secretion secretion|amod|END_ENTITY	Microinjection of dihydrotestosterone into the medial preoptic area produces male-like pattern of growth_hormone secretion in ovariectomized female rats .
1381827	0	dihydrotestosterone	60,79	growth_hormone	19,33	dihydrotestosterone	growth hormone	MESH:D013196	81668(Tax:10116)	Chemical	Gene	pattern|nmod|START_ENTITY pattern|amod|END_ENTITY	Masculinization of growth_hormone -LRB- GH -RRB- secretory pattern by dihydrotestosterone is associated with augmentation of hypothalamic somatostatin_and_GH-releasing_hormone mRNA levels in ovariectomized adult rats .
12954658	0	dihydrotestosterone	75,94	prostate-specific_antigen	17,42	dihydrotestosterone	prostate-specific antigen	MESH:D013196	354	Chemical	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|expression expression|compound|END_ENTITY	Androgen-induced prostate-specific_antigen gene expression is mediated via dihydrotestosterone in LNCaP cells .
7507237	0	dihydrotestosterone	108,127	prostate-specific_antigen	14,39	dihydrotestosterone	prostate-specific antigen	MESH:D013196	354	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of prostate-specific_antigen gene expression in LNCaP human prostatic_carcinoma cells by growth , dihydrotestosterone , and extracellular matrix .
7530653	0	dihydrotestosterone	128,147	prostate-specific_antigen	46,71	dihydrotestosterone	prostate-specific antigen	MESH:D013196	354	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of proliferation and production of prostate-specific_antigen in androgen-sensitive prostatic_cancer cells , LNCaP , by dihydrotestosterone .
561671	0	dihydrotestosterone	24,43	sex_hormone_binding_globulin	78,106	dihydrotestosterone	sex hormone binding globulin	MESH:D013196	6462	Chemical	Gene	the|nmod|START_ENTITY the|nmod|END_ENTITY	Study on the binding of dihydrotestosterone , testosterone and oestradiol with sex_hormone_binding_globulin .
15907775	0	dihydrouracil	70,83	endonucleases_III_and_VIII	16,42	dihydrouracil	endonucleases III and VIII	MESH:C007419	79661	Chemical	Gene	Action|nmod|START_ENTITY Action|nmod|END_ENTITY	Action of human endonucleases_III_and_VIII upon DNA-containing tandem dihydrouracil .
7986820	0	dihydrouracils	86,100	human_leukocyte_elastase	30,54	dihydrouracils	human leukocyte elastase	null	1991	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Mechanism-based inhibition of human_leukocyte_elastase and cathepsin_G by substituted dihydrouracils .
11816056	0	dihydroxyacetone_phosphate	53,79	alkaline_phosphatase	26,46	dihydroxyacetone phosphate	alkaline phosphatase	MESH:D004099	250	Chemical	Gene	using|dobj|START_ENTITY END_ENTITY|acl|using	Chemiluminescent assay of alkaline_phosphatase using dihydroxyacetone_phosphate as substrate detected with lucigenin .
7649976	0	dihydroxycholecalciferol	35,59	JunD	27,31	dihydroxycholecalciferol	JunD	null	3727	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of JunD by dihydroxycholecalciferol in human chronic_myelogenous_leukemia cells .
19711907	0	dihydroxydione	86,100	BF2	69,72	dihydroxydione	BF2	null	2290	Chemical	Gene	complex|nmod|START_ENTITY complex|compound|END_ENTITY	Synthesis , crystal structure , and electron-accepting property of the BF2 complex of a dihydroxydione with a perfluorotetracene skeleton .
19053501	0	dihydroxydiones	45,60	BF2	28,31	dihydroxydiones	BF2	null	2290	Chemical	Gene	complexes|nmod|START_ENTITY complexes|nummod|END_ENTITY	Synthesis and properties of BF2 complexes to dihydroxydiones of tetracene and perylene : novel electron acceptors showing n-type semiconducting behavior .
23469848	0	dihydroxyflavone	27,43	TrkB	0,4	dihydroxyflavone	TrkB	CHEBI:38686	18212(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	TrkB receptor agonist 7 , 8 dihydroxyflavone triggers profound gender - dependent neuroprotection in mice after perinatal hypoxia and ischemia .
21994003	0	dihydroxyvitamin_D	31,49	GPR30	16,21	dihydroxyvitamin D	GPR30	null	76854(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Contribution Contribution|nmod|END_ENTITY	Contribution of GPR30 for 1,25 dihydroxyvitamin_D protection in EAE .
15531134	0	dihydroxyvitamin_D3	21,40	HO-1	62,66	dihydroxyvitamin D3	HO-1	MESH:C118756	3162	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of 1alpha ,25 dihydroxyvitamin_D3 on the expression of HO-1 and GFAP in glial cells of the photothrombotically lesioned cerebral cortex .
22622019	0	diindolylmethane	49,65	JAK2	40,44	diindolylmethane	JAK2	MESH:C444299	3717	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of Janus-activated_kinase-2 -LRB- JAK2 -RRB- by diindolylmethane in ovarian_cancer in vitro and in vivo .
22622019	0	diindolylmethane	49,65	Janus-activated_kinase-2	14,38	diindolylmethane	Janus-activated kinase-2	MESH:C444299	3717	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of Janus-activated_kinase-2 -LRB- JAK2 -RRB- by diindolylmethane in ovarian_cancer in vitro and in vivo .
9156554	0	diiodofluorescein_iodoacetamide	70,101	cytochrome_P450scc	36,54	diiodofluorescein iodoacetamide	cytochrome P450scc	MESH:C083114	338048(Tax:9913)	Chemical	Gene	modification|nmod|START_ENTITY modification|nmod|END_ENTITY	-LSB- Selective chemical modification of cytochrome_P450scc -LRB- CYP11A1 -RRB- with diiodofluorescein_iodoacetamide in the study of the role and topology of interdomain hinge of the hemoprotein molecule -RSB- .
18602967	0	diisobutyl_phthalate	10,30	PPAR	41,45	diisobutyl phthalate	PPAR	MESH:C025605	25747(Tax:10116)	Chemical	Gene	agonists|compound|START_ENTITY agonists|compound|END_ENTITY	Impact of diisobutyl_phthalate and other PPAR agonists on steroidogenesis and plasma insulin and leptin levels in fetal rats .
6313528	0	diisocyanates	38,51	acetylcholinesterase	14,34	diisocyanates	acetylcholinesterase	CHEBI:53213	43	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of acetylcholinesterase by diisocyanates and its spontaneous reactivation .
12965124	0	diisononyl_phthalate	77,97	peroxisome_proliferator-activated_receptor_alpha	12,60	diisononyl phthalate	peroxisome proliferator-activated receptor alpha	MESH:C012125	19013(Tax:10090)	Chemical	Gene	Role|acl|START_ENTITY Role|nmod|END_ENTITY	Role of the peroxisome_proliferator-activated_receptor_alpha in responses to diisononyl_phthalate .
22697068	0	diisononylphthalate	32,51	THP-1	55,60	diisononylphthalate	THP-1	MESH:C012125	2736	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Effects of 4-nonylphenol and/or diisononylphthalate on THP-1 cells : impact of endocrine disruptors on human immune system parameters .
10761975	0	diisopropyl_phosphorofluoridate	70,101	C-fos	0,5	diisopropyl phosphorofluoridate	C-fos	MESH:D007531	2353	Chemical	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	C-fos mRNA induction in the central and peripheral nervous systems of diisopropyl_phosphorofluoridate -LRB- DFP -RRB- - treated hens .
2095778	0	diisopropyl_phosphorofluoridate	11,42	CA3	52,55	diisopropyl phosphorofluoridate	CA3	MESH:D007531	54232(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|responses responses|compound|END_ENTITY	Effects of diisopropyl_phosphorofluoridate -LRB- DFP -RRB- on CA3 and CA1 responses in rat hippocampus .
16443250	0	diisopropylfluorophosphate	32,58	acetylcholinesterase	96,116	diisopropylfluorophosphate	acetylcholinesterase	MESH:D007531	11423(Tax:10090)	Chemical	Gene	toxicity|nmod|START_ENTITY Protection|nmod|toxicity Protection|acl|expressing expressing|dobj|END_ENTITY	Protection from the toxicity of diisopropylfluorophosphate by adeno-associated virus expressing acetylcholinesterase .
20178819	0	diisopropylfluorophosphate	132,158	acetylcholinesterase	56,76	diisopropylfluorophosphate	acetylcholinesterase	MESH:D007531	11423(Tax:10090)	Chemical	Gene	stress|nmod|START_ENTITY dependence|nmod|stress dependence|nmod|END_ENTITY	Strain and regional dependence of alternate splicing of acetylcholinesterase in the murine brain following stress or treatment with diisopropylfluorophosphate .
20981864	0	diisopropylfluorophosphate	35,61	acetylcholinesterase	91,111	diisopropylfluorophosphate	acetylcholinesterase	MESH:D007531	83817(Tax:10116)	Chemical	Gene	exposure|nmod|START_ENTITY Pretreatment|nmod|exposure Pretreatment|nmod|efficacy efficacy|nmod|inhibitors inhibitors|compound|END_ENTITY	Pretreatment for acute exposure to diisopropylfluorophosphate : in vivo efficacy of various acetylcholinesterase inhibitors .
2256118	0	diisopropylfluorophosphate	110,136	acetylcholinesterase	86,106	diisopropylfluorophosphate	acetylcholinesterase	MESH:D007531	83817(Tax:10116)	Chemical	Gene	based|nmod|START_ENTITY based|nmod|inhibition inhibition|nmod|END_ENTITY	Physiologically based pharmacokinetic and pharmacodynamic model for the inhibition of acetylcholinesterase by diisopropylfluorophosphate .
2496574	0	diisopropylfluorophosphate	51,77	acetylcholinesterase	27,47	diisopropylfluorophosphate	acetylcholinesterase	MESH:D007531	83817(Tax:10116)	Chemical	Gene	Differences|acl|START_ENTITY Differences|nmod|response response|nmod|END_ENTITY	Differences in response of acetylcholinesterase to diisopropylfluorophosphate in the mesencephalic raphe region .
2709438	0	diisopropylfluorophosphate	29,55	acetylcholinesterase	103,123	diisopropylfluorophosphate	acetylcholinesterase	MESH:D007531	11423(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY Comparison|nmod|effects END_ENTITY|nsubj|Comparison	Comparison of the effects of diisopropylfluorophosphate , sarin , soman , and tabun on toxicity and brain acetylcholinesterase activity in mice .
2913485	0	diisopropylfluorophosphate	64,90	acetylcholinesterase	22,42	diisopropylfluorophosphate	acetylcholinesterase	MESH:D007531	43	Chemical	Gene	inactivation|nmod|START_ENTITY END_ENTITY|nmod|inactivation	Tacrine protection of acetylcholinesterase from inactivation by diisopropylfluorophosphate : a circular dichroism study .
3574585	0	diisopropylfluorophosphate	101,127	acetylcholinesterase	49,69	diisopropylfluorophosphate	acetylcholinesterase	MESH:D007531	83817(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY distribution|nmod|treatment distribution|nmod|forms forms|nmod|END_ENTITY	Intracellular distribution of molecular forms of acetylcholinesterase in rat brain and changes after diisopropylfluorophosphate treatment .
8973828	0	diisopropylfluorophosphate	138,164	acetylcholinesterase	94,114	diisopropylfluorophosphate	acetylcholinesterase	MESH:D007531	83817(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY release|dep|effects release|nmod|cortex cortex|nmod|rat rat|acl|measured measured|nmod|inhibitors inhibitors|amod|END_ENTITY	Acetylcholine release from frontal cortex in the waking rat measured by microdialysis without acetylcholinesterase inhibitors : effects of diisopropylfluorophosphate .
1033176	0	dilactone	22,31	catechol-O-methyl_transferase	49,78	dilactone	catechol-O-methyl transferase	null	24267(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Dehydrodicaffeic_acid dilactone , an inhibitor of catechol-O-methyl_transferase .
406914	0	dilauroylglycerophosphocholine	84,114	albumin	40,47	dilauroylglycerophosphocholine	albumin	null	213	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Effects Effects|nmod|END_ENTITY	Effects of temperature and bovine serum albumin on lysis of erythrocytes induced by dilauroylglycerophosphocholine and didecanoylglycerophosphocholine .
10867547	0	dilazep_dihydrochloride	10,33	P-selectin	44,54	dilazep dihydrochloride	P-selectin	null	6403	Chemical	Gene	concentrations|amod|START_ENTITY concentrations|amod|END_ENTITY	Effect of dilazep_dihydrochloride on plasma P-selectin concentrations in patients with IgA_nephropathy .
12946999	0	dileucine	32,41	CD28	27,31	dileucine	CD28	null	12487(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification of a murine CD28 dileucine motif that suppresses single-chain chimeric T-cell_receptor expression and function .
21576029	0	dilmapimod	47,57	p38	22,25	dilmapimod	p38	MESH:C574213	1432	Chemical	Gene	START_ENTITY|nsubj|trial trial|nmod|inhibitor inhibitor|amod|END_ENTITY	Clinical trial of the p38 MAP kinase inhibitor dilmapimod in neuropathic_pain following nerve_injury .
11560871	0	diltiazem	32,41	CYP3A4	11,17	diltiazem	CYP3A4	MESH:D004110	1576	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|Effects Effects|nmod|END_ENTITY	Effects of CYP3A4 inhibition by diltiazem on pharmacokinetics and dynamics of diazepam in relation to CYP2C19 genotype status .
16024008	0	diltiazem	70,79	CYP3A5	15,21	diltiazem	CYP3A5	MESH:D004110	1577	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY Effects|nmod|pharmacokinetics Effects|nmod|polymorphism polymorphism|compound|END_ENTITY	Effects of the CYP3A5 genetic polymorphism on the pharmacokinetics of diltiazem .
20514078	0	diltiazem	11,20	CYP3A5	70,76	diltiazem	CYP3A5	MESH:D004110	1577	Chemical	Gene	START_ENTITY|nmod|pharmacokinetics pharmacokinetics|nmod|tacrolimus tacrolimus|nmod|relation relation|nmod|END_ENTITY	Effects of diltiazem on pharmacokinetics of tacrolimus in relation to CYP3A5 genotype status in renal recipients : from retrospective to prospective .
23700791	0	diltiazem	77,86	CYP3A5	11,17	diltiazem	CYP3A5	MESH:D004110	1577	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY polymorphism|nmod|pharmacokinetics polymorphism|nsubj|Effects Effects|nmod|END_ENTITY	Effects of CYP3A5 and CYP2D6 genetic polymorphism on the pharmacokinetics of diltiazem and its metabolites in Chinese subjects .
8977475	0	diltiazem	24,33	Ca2	65,68	diltiazem	Ca2	MESH:D004110	280740(Tax:9913)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|concentration concentration|compound|END_ENTITY	Differential effects of diltiazem and nitroglycerin on cytosolic Ca2 + concentration and on force in the bovine ophthalmic artery .
19040346	0	dimeglumine	14,25	neurokinin-1	65,77	dimeglumine	neurokinin-1	null	6863	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Fosaprepitant dimeglumine -LRB- MK-0517 or L-785 ,298 -RRB- , an intravenous neurokinin-1 antagonist for the prevention of chemotherapy induced nausea and vomiting .
12754110	0	dimercaptosuccinic_acid	15,38	angiotensin_II	51,65	dimercaptosuccinic acid	angiotensin II	MESH:D004113	24179(Tax:10116)	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of dimercaptosuccinic_acid -LRB- DMSA -RRB- with angiotensin_II on calcium mobilization in vascular smooth muscle cells .
20457138	0	dimerumic_acid	14,28	Mrp2	62,66	dimerumic acid	Mrp2	MESH:C552122	25303(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of dimerumic_acid on LPS-induced downregulation of Mrp2 in the rat .
15779760	0	dimethoate	13,23	acetylcholinesterase	27,47	dimethoate	acetylcholinesterase	MESH:D004117	43	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Influence of dimethoate on acetylcholinesterase activity and locomotor function in terrestrial isopods .
24459918	0	dimethoate	14,24	acetylcholinesterase	57,77	dimethoate	acetylcholinesterase	MESH:D004117	83817(Tax:10116)	Chemical	Gene	Impacts|acl:relcl|START_ENTITY inhibited|nsubj|Impacts inhibited|dobj|dose dose|nmod|END_ENTITY	-LSB- Impacts that dimethoate inhibited the benchmark dose of acetylcholinesterase based on experimental designs -RSB- .
11939005	0	dimethoate	11,21	c-fos	43,48	dimethoate	c-fos	MESH:D004117	314322(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|gene gene|amod|END_ENTITY	-LSB- Effect of dimethoate on the expression of c-fos gene in skeletal muscle -RSB- .
1816087	0	dimethoate	10,20	cytochrome_P-450	32,48	dimethoate	cytochrome P-450	MESH:D004117	25251(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of dimethoate on hepatic cytochrome_P-450 and glutathione_S-transferase activity in pigeon and rat .
16701032	0	dimethoate	11,21	heat_shock_protein_70	43,64	dimethoate	heat shock protein 70	MESH:D004117	3308	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of dimethoate on the expression of heat_shock_protein_70 in peripheral blood lymphocytes of human beings -RSB- .
4388191	0	dimethothiazine	25,40	Bradykinin	0,10	dimethothiazine	Bradykinin	MESH:C100113	3827	Chemical	Gene	antagonism|nmod|START_ENTITY antagonism|nsubj|END_ENTITY	Bradykinin antagonism by dimethothiazine .
12397032	0	dimethyl	74,82	NaDC-3	53,59	dimethyl	NaDC-3	CHEBI:42266	64849	Chemical	Gene	transporter|amod|START_ENTITY transporter|amod|END_ENTITY	The renal Na -LRB- + -RRB- - dependent dicarboxylate transporter , NaDC-3 , translocates dimethyl - and disulfhydryl-compounds and contributes to renal_heavy_metal_detoxification .
15757665	0	dimethyl-alpha-cyclodextrin	49,76	CD14	15,19	dimethyl-alpha-cyclodextrin	CD14	MESH:C479660	929	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of CD14 in the inhibitory effects of dimethyl-alpha-cyclodextrin on lipopolysaccharide signaling in macrophages .
15139519	0	dimethyl-beta-cyclodextrin	70,96	P-glycoprotein	119,133	dimethyl-beta-cyclodextrin	P-glycoprotein	MESH:C038119	5243	Chemical	Gene	START_ENTITY|nmod|function function|nmod|END_ENTITY	Contribution of cholesterol and phospholipids to inhibitory effect of dimethyl-beta-cyclodextrin on efflux function of P-glycoprotein and multidrug_resistance-associated_protein_2 in vinblastine-resistant Caco-2 cell monolayers .
12899636	0	dimethyl_sulfoxide	73,91	CymA	25,29	dimethyl sulfoxide	CymA	MESH:D004121	1172176(Tax:211586)	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	The tetraheme cytochrome CymA is required for anaerobic respiration with dimethyl_sulfoxide and nitrite in Shewanella_oneidensis .
11162043	0	dimethyl_sulfoxide	22,40	ICAM-1	44,50	dimethyl sulfoxide	ICAM-1	MESH:D004121	25464(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Therapeutic effect of dimethyl_sulfoxide on ICAM-1 gene expression and activation of NF-kappaB and AP-1 in septic rats .
9035283	0	dimethyl_sulfoxide	39,57	NF-kappa_B	14,24	dimethyl sulfoxide	NF-kappa B	MESH:D004121	18033(Tax:10090)	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Inhibition of NF-kappa_B activation by dimethyl_sulfoxide correlates with suppression of TNF-alpha formation , reduced ICAM-1 gene transcription , and protection against endotoxin-induced liver_injury .
3876185	0	dimethyl_sulfoxide	11,29	acetylcholine_receptors	61,84	dimethyl sulfoxide	acetylcholine receptors	MESH:D004121	170945(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of dimethyl_sulfoxide on humoral immune responses to acetylcholine_receptors in the rat .
9374131	0	dimethyl_sulfoxide	11,29	apolipoprotein_A-I	33,51	dimethyl sulfoxide	apolipoprotein A-I	MESH:D004121	335	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of dimethyl_sulfoxide on apolipoprotein_A-I in the human hepatoma cell line , HepG2 .
16214121	0	dimethyl_sulfoxide	14,32	cytochrome_P450_2D6	52,71	dimethyl sulfoxide	cytochrome P450 2D6	MESH:D004121	1565	Chemical	Gene	START_ENTITY|nmod|function function|nmod|END_ENTITY	The effect of dimethyl_sulfoxide on the function of cytochrome_P450_2D6 in HepG2 cells upon the co-expression with NADPH-cytochrome P450 reductase .
1828251	0	dimethyl_sulfoxide	13,31	epidermal_growth_factor	63,86	dimethyl sulfoxide	epidermal growth factor	MESH:D004121	25313(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|properties properties|nmod|END_ENTITY	Effect of 2 % dimethyl_sulfoxide on the mitogenic properties of epidermal_growth_factor and hepatocyte_growth_factor in primary hepatocyte culture .
6192745	0	dimethyl_sulfoxide	36,54	growth_hormone	85,99	dimethyl sulfoxide	growth hormone	MESH:D004121	14599(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|nmod|END_ENTITY	The in vitro and in vivo effects of dimethyl_sulfoxide on the pituitary secretion of growth_hormone and prolactin in mice .
14603493	3	dimethyl_sulfoxide	487,505	insulin	546,553	dimethyl sulfoxide	insulin	MESH:D004121	3630	Chemical	Gene	solutions|amod|START_ENTITY precipitated|nmod|solutions precipitated|advcl|dispersing dispersing|dobj|solutions solutions|compound|END_ENTITY	Insulin powder was precipitated from dimethyl_sulfoxide and aqueous solutions by dispersing the insulin solutions from parallel and V-type nozzles , respectively , into supercritical carbon_dioxide , which is an antisolvent for insulin .
7020010	0	dimethyl_sulfoxide	15,33	insulin	37,44	dimethyl sulfoxide	insulin	MESH:D004121	3630	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|release release|compound|END_ENTITY	The effects of dimethyl_sulfoxide on insulin release and phosphate efflux from isolated , perifused islets of Langerhans .
420863	0	dimethyl_sulfoxide	42,60	insulin_receptor	14,30	dimethyl sulfoxide	insulin receptor	MESH:D004121	3643	Chemical	Gene	binding|nmod|START_ENTITY binding|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of insulin_receptor binding by dimethyl_sulfoxide .
11056391	0	dimethyl_sulfoxide	11,29	matrix_metalloproteinase_7	89,115	dimethyl sulfoxide	matrix metalloproteinase 7	MESH:D004121	4316	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of dimethyl_sulfoxide , temperature , and sodium_chloride on the activity of human matrix_metalloproteinase_7 -LRB- matrilysin -RRB- .
12459902	0	dimethyl_sulfoxide	64,82	myoglobin	51,60	dimethyl sulfoxide	myoglobin	MESH:D004121	100054434(Tax:9796)	Chemical	Gene	studies|nmod|START_ENTITY studies|nmod|END_ENTITY	Spectroscopic and electrochemical studies of horse myoglobin in dimethyl_sulfoxide .
2512391	0	dimethyl_sulfoxide	109,127	synaptophysin	14,27	dimethyl sulfoxide	synaptophysin	MESH:D004121	24804(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY Expression|dep|effects Expression|nmod|END_ENTITY	Expression of synaptophysin and neuron-specific_enolase during neuronal differentiation in vitro : effects of dimethyl_sulfoxide .
22300296	0	dimethylallyl_pyrophosphate	44,71	TRPV4	76,81	dimethylallyl pyrophosphate	TRPV4	CHEBI:16057	59341	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activation activation|compound|END_ENTITY	Nociceptive and pro-inflammatory effects of dimethylallyl_pyrophosphate via TRPV4 activation .
1507071	0	dimethylaniline	110,125	cytochrome_P-450	37,53	dimethylaniline	cytochrome P-450	CHEBI:23806	100328948(Tax:9986)	Chemical	Gene	pathways|nmod|START_ENTITY pathways|amod|END_ENTITY	An assessment of cadmium toxicity on cytochrome_P-450 and flavin monooxygenase-mediated metabolic pathways of dimethylaniline in male rabbits .
23255608	0	dimethylarginine	11,27	Akt1	144,148	dimethylarginine	Akt1	null	207	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Asymmetric dimethylarginine induces endothelial_nitric-oxide_synthase mitochondrial redistribution through the nitration-mediated activation of Akt1 .
24962795	0	dimethylarginine	11,27	C-reactive_protein	64,82	dimethylarginine	C-reactive protein	null	1401	Chemical	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	Asymmetric dimethylarginine is associated with high-sensitivity C-reactive_protein and early carotid atherosclerosis in women with previous_gestational_diabetes_mellitus .
23834755	0	dimethylarginine	18,34	CCL5	10,14	dimethylarginine	CCL5	null	81780(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY Effect|nmod|production Effect|nmod|END_ENTITY	Effect of CCL5 on dimethylarginine dimethylaminohydrolase-1 production in vascular smooth muscle cells from spontaneously hypertensive rats .
15728783	0	dimethylarginine	36,52	Erythropoietin	0,14	dimethylarginine	Erythropoietin	null	2056	Chemical	Gene	increases|dobj|START_ENTITY increases|nsubj|END_ENTITY	Erythropoietin increases asymmetric dimethylarginine in endothelial cells : role of dimethylarginine_dimethylaminohydrolase .
18785307	0	dimethylarginine	21,37	FMF	93,96	dimethylarginine	FMF	null	4210	Chemical	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Increased asymmetric dimethylarginine levels in young men with familial_Mediterranean_fever -LRB- FMF -RRB- : is it early evidence of interaction between inflammation and endothelial_dysfunction in FMF ?
21269946	0	dimethylarginine	21,37	MIF	41,44	dimethylarginine	MIF	null	4282	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effect of asymmetric dimethylarginine on MIF expression and TNF-a and IL-8 secretion in THP-1 monocytes-derived macrophages .
22458913	0	dimethylarginine	26,42	Osteopontin	0,11	dimethylarginine	Osteopontin	null	6696	Chemical	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	Osteopontin and symmetric dimethylarginine plasma levels in solitary functioning kidney in children .
20018850	0	dimethylarginine	62,78	alanine-glyoxylate_aminotransferase_2	6,43	dimethylarginine	alanine-glyoxylate aminotransferase 2	null	64902	Chemical	Gene	lowers|dobj|START_ENTITY lowers|nsubj|END_ENTITY	Human alanine-glyoxylate_aminotransferase_2 lowers asymmetric dimethylarginine and protects from inhibition of nitric_oxide production .
18083252	0	dimethylarginine	70,86	angiotensin-converting_enzyme	10,39	dimethylarginine	angiotensin-converting enzyme	null	1636	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|inhibitor inhibitor|amod|END_ENTITY	Effect of angiotensin-converting_enzyme inhibitor on serum asymmetric dimethylarginine and coronary circulation in patients with type_2_diabetes_mellitus .
22000584	0	dimethylarginine	121,137	dimethylarginine_dimethylaminohydrolase	8,47	dimethylarginine	dimethylarginine dimethylaminohydrolase	null	23576	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|activity activity|amod|END_ENTITY	Role of dimethylarginine_dimethylaminohydrolase activity in regulation of tissue and plasma concentrations of asymmetric dimethylarginine in an animal model of prolonged critical_illness .
20941830	0	dimethylarginine	70,86	endothelin-1	43,55	dimethylarginine	endothelin-1	null	1906	Chemical	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	Taxane-based adjuvant chemotherapy reduces endothelin-1 and symmetric dimethylarginine levels in patients with breast_cancer .
25172154	0	dimethylarginine	23,39	growth_hormone	88,102	dimethylarginine	growth hormone	null	2688	Chemical	Gene	START_ENTITY|nmod|deficiency deficiency|amod|END_ENTITY	Circulating asymmetric dimethylarginine and lipid profile in pre-pubertal children with growth_hormone deficiency : Effect of 12-month growth_hormone replacement therapy .
18498242	0	dimethylarginine	89,105	insulin	30,37	dimethylarginine	insulin	null	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of acute variations of insulin and glucose on plasma concentrations of asymmetric dimethylarginine in young people with Type_1_diabetes .
24478314	0	dimethylarginine	77,93	protein_arginine_methyltransferase_1	12,48	dimethylarginine	protein arginine methyltransferase 1	null	3276	Chemical	Gene	generates|dobj|START_ENTITY generates|nsubj|END_ENTITY	A remodeled protein_arginine_methyltransferase_1 -LRB- PRMT1 -RRB- generates symmetric dimethylarginine .
7317537	0	dimethylcyclohexylamine	56,79	methemoglobin	114,127	dimethylcyclohexylamine	methemoglobin	CHEBI:59022	3048	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Effects of phospholipids on oxidative demethylation of dimethylcyclohexylamine by cumene_hydroperoxide involving methemoglobin -RSB- .
6336473	0	dimethylformamide	15,32	cytochrome_P-450	58,74	dimethylformamide	cytochrome P-450	MESH:D004126	25251(Tax:10116)	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of dimethylformamide and its metabolites with cytochrome_P-450 in microsomal fraction of rat liver .
18973187	0	dimethylhydrazine	71,88	Necl-5	8,14	dimethylhydrazine	Necl-5	null	52118(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Role Role|nmod|END_ENTITY	Role of Necl-5 in the pathophysiology of colorectal_lesions induced by dimethylhydrazine and/or dextran_sodium_sulphate .
2386947	0	dimethylnitrosamine	99,118	O6-methylguanine-DNA_methyltransferase	14,52	dimethylnitrosamine	O6-methylguanine-DNA methyltransferase	MESH:D004128	25332(Tax:10116)	Chemical	Gene	liver|nmod|START_ENTITY liver|nsubj|Modulation Modulation|nmod|END_ENTITY	Modulation of O6-methylguanine-DNA_methyltransferase in rat and hamster liver after treatment with dimethylnitrosamine .
2505067	0	dimethylnitrosamine	19,38	O6-methylguanine-DNA_methyltransferase	71,109	dimethylnitrosamine	O6-methylguanine-DNA methyltransferase	MESH:D004128	17314(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|levels levels|compound|END_ENTITY	Combined effect of dimethylnitrosamine and a lysine-restricted diet on O6-methylguanine-DNA_methyltransferase levels in mouse tissues .
3106802	0	dimethylnitrosamine	86,105	O6-methylguanine-DNA_methyltransferase	0,38	dimethylnitrosamine	O6-methylguanine-DNA methyltransferase	MESH:D004128	17314(Tax:10090)	Chemical	Gene	exposed|xcomp|START_ENTITY exposed|nsubj|END_ENTITY	O6-methylguanine-DNA_methyltransferase and alkylation of liver DNA in mice exposed to dimethylnitrosamine during dietary deficiency of essential amino_acids .
9804924	0	dimethylnitrosamine	74,93	lacI	8,12	dimethylnitrosamine	lacI	MESH:D004128	29436(Tax:10116)	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|END_ENTITY	Hepatic lacI and cII mutation in transgenic -LRB- lambdaLIZ -RRB- rats treated with dimethylnitrosamine .
9862195	0	dimethylnitrosamine	32,51	lacI	59,63	dimethylnitrosamine	lacI	MESH:D004128	21788(Tax:10090)	Chemical	Gene	spectrum|nmod|START_ENTITY spectrum|nmod|transgene transgene|amod|END_ENTITY	Specific mutational spectrum of dimethylnitrosamine in the lacI transgene of Big Blue C57BL/6 mice .
24728967	0	dimethylnitrosamine	58,77	phospholipase_D1	12,28	dimethylnitrosamine	phospholipase D1	MESH:D004128	25096(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|role role|nmod|END_ENTITY	The role of phospholipase_D1 in liver fibrosis induced by dimethylnitrosamine in vivo .
2163046	0	dimethylphenylpiperazinium	30,56	Neuropeptide_Y	0,14	dimethylphenylpiperazinium	Neuropeptide Y	MESH:D004246	24604(Tax:10116)	Chemical	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Neuropeptide_Y -LRB- NPY -RRB- inhibits dimethylphenylpiperazinium -LRB- DMPP -RRB- - induced gastric_acid secretion in isolated rat stomach .
18490849	0	dimethylsulfoniopropionate	157,183	nerve_growth_factor	203,222	dimethylsulfoniopropionate	nerve growth factor	MESH:C068078	310738(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|presence presence|nmod|END_ENTITY	Inhibition of the outgrowth and elongation of neurites from pheochromocytoma cells by 1-methyl-4-phenyl-1 ,2,3,6 - tetrahydropyridine and preventive effects of dimethylsulfoniopropionate in the presence of nerve_growth_factor .
3951994	0	dimethylsulfoxide	24,41	DNA_polymerases_alpha	69,90	dimethylsulfoxide	DNA polymerases alpha	MESH:D004121	5422	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activities activities|nmod|END_ENTITY	Differential effects of dimethylsulfoxide on the activities of human DNA_polymerases_alpha and delta .
10347764	0	dimethylsulfoxide	10,27	Niemann-Pick_type_C	87,106	dimethylsulfoxide	Niemann-Pick type C	MESH:D004121	4864	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	Effect of dimethylsulfoxide on sphingomyelinase activity and cholesterol metabolism in Niemann-Pick_type_C fibroblasts .
8765690	1	dimethylsulfoxide	131,148	catalase	212,220	dimethylsulfoxide	catalase	MESH:D004121	24248(Tax:10116)	Chemical	Gene	copper-ions|dep|START_ENTITY copper-ions|amod|superoxide superoxide|amod|END_ENTITY	Kinetics and influence of ascorbic_acid , glutathione , dimethylsulfoxide , N-t-butyl-a-phenyl-nitrone , copper-ions and a copper complex , catalase , superoxide dismutase , hexobarbital and aniline .
7111985	0	dimethylxanthine	49,65	Gastrin	0,7	dimethylxanthine	Gastrin	CHEBI:23818	2520	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|release release|compound|END_ENTITY	Gastrin release and gastric secretion induced by dimethylxanthine in man .
24578214	6	diminazene_aceturate	795,815	SSAT-1	838,844	diminazene aceturate	DNMT-1	MESH:C003915	1786	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	In addition , synovial fibroblasts were treated with diminazene_aceturate -LRB- DA -RRB- , an inhibitor of SSAT-1 .
6783071	0	dimyristoylphosphatidylcholine	118,148	apolipoprotein_A-I	86,104	dimyristoylphosphatidylcholine	apolipoprotein A-I	MESH:D004134	335	Chemical	Gene	complexes|nmod|START_ENTITY complexes|amod|END_ENTITY	Raman spectroscopy of the thermal properties of reassembled high-density lipoprotein : apolipoprotein_A-I complexes of dimyristoylphosphatidylcholine .
8396448	0	dimyristoylphosphatidylcholine	61,91	rhodopsin	48,57	dimyristoylphosphatidylcholine	rhodopsin	MESH:D004134	6010	Chemical	Gene	kinetics|nmod|START_ENTITY kinetics|nmod|END_ENTITY	The kinetics and thermodynamics of bleaching of rhodopsin in dimyristoylphosphatidylcholine .
25578475	0	dinaciclib	19,29	CDK9	0,4	dinaciclib	CDK9	MESH:C553669	1025	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nummod|END_ENTITY	CDK9 inhibition by dinaciclib potently suppresses Mcl-1 to induce durable apoptotic responses in aggressive MYC-driven B-cell_lymphoma in vivo .
6453612	0	dinitrophenol	67,80	mitochondrial_ATPase	40,60	dinitrophenol	mitochondrial ATPase	CHEBI:39352	514	Chemical	Gene	using|dobj|START_ENTITY END_ENTITY|acl|using	Studies of the kinetics of the isolated mitochondrial_ATPase using dinitrophenol as a probe .
15590889	0	dinitrophenyl-S-glutathione	61,88	Mrp2	15,19	dinitrophenyl-S-glutathione	Mrp2	CHEBI:8927	25303(Tax:10116)	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of Mrp2 in hepatic and intestinal disposition of dinitrophenyl-S-glutathione in partially hepatectomized rats .
15246872	4	dinucleoside_polyphosphate	585,611	Fhit	634,638	dinucleoside polyphosphate	Fhit	null	2272	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Our experiments showed that the dinucleoside_polyphosphate hydrolase activity of Fhit is suppressed by interacting with hUbc9 protein .
15291552	0	dinucleoside_polyphosphate	80,106	Fhit	18,22	dinucleoside polyphosphate	Fhit	null	2272	Chemical	Gene	synthase|compound|START_ENTITY END_ENTITY|nmod|synthase	Engineering human Fhit , a diadenosine_triphosphate hydrolase , into an efficient dinucleoside_polyphosphate synthase .
12028594	0	dinucleoside_polyphosphates	11,38	HNT2	62,66	dinucleoside polyphosphates	HNT2	MESH:D015226	851899(Tax:4932)	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Control of dinucleoside_polyphosphates by the FHIT-homologous HNT2 gene , adenine biosynthesis and heat_shock in Saccharomyces_cerevisiae .
8012498	0	dinucleoside_polyphosphates	34,61	casein_kinase_II	14,30	dinucleoside polyphosphates	casein kinase II	MESH:D015226	1457	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of casein_kinase_II by dinucleoside_polyphosphates .
14613874	10	dioctanoyl_PA	1538,1551	COX-2	1562,1567	dioctanoyl PA	AngII	null	24179(Tax:10116)	Chemical	Gene	increased|nsubj|START_ENTITY increased|dobj|expression expression|compound|END_ENTITY	Inhibition of PLD-mediated phosphatidic_acid -LRB- PA -RRB- formation by 1 % 1-butanol abolished AngII-induced COX-2 expression and PGI -LRB- 2 -RRB- secretion , while dioctanoyl_PA increased COX-2 expression and PGI -LRB- 2 -RRB- production in a time - and concentration-dependent manner .
18047799	0	dioscin	39,46	growth_hormone	13,27	dioscin	growth hormone	MESH:C019357	81668(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY release|amod|END_ENTITY	Induction of growth_hormone release by dioscin from Dioscorea batatas DECNE .
24866061	0	dioscin	114,121	mOAT1	140,145	dioscin	mOAT1	MESH:C019357	18399(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Anti-hyperuricemic and nephroprotective effects of Rhizoma Dioscoreae septemlobae extracts and its main component dioscin via regulation of mOAT1 , mURAT1 and mOCT2 in hypertensive mice .
26408789	0	diosgenin	10,19	ERb	54,57	diosgenin	ERb	MESH:D004144	13983(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|Role Role|nmod|END_ENTITY	Effect of diosgenin on metabolic_dysfunction : Role of ERb in the regulation of PPARy .
24973886	0	diosgenin	18,27	hTERT	59,64	diosgenin	hTERT	MESH:D004144	7015	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|expression expression|amod|END_ENTITY	Fenugreek extract diosgenin and pure diosgenin inhibit the hTERT gene expression in A549_lung_cancer cell line .
24263408	0	diosgenyl_saponin	50,67	estrogen_receptor-a	95,114	diosgenyl saponin	estrogen receptor-a	null	2099	Chemical	Gene	START_ENTITY|nmod|suppression suppression|nmod|END_ENTITY	The induction of apoptosis by a newly synthesized diosgenyl_saponin through the suppression of estrogen_receptor-a in MCF-7 human breast_cancer cells .
23709168	0	diosmetin	33,42	c-Kit	14,19	diosmetin	c-Kit	MESH:C039602	3815	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Inhibition of c-Kit signaling by diosmetin isolated from Chrysanthemum morifolium .
21477647	0	diosmin	21,28	TNF-a	86,91	diosmin	TNF-a	MESH:D004145	24835(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|amod|END_ENTITY	Protective effect of diosmin on LPS-induced apoptosis in PC12 cells and inhibition of TNF-a expression .
8741762	0	dioxin	4,10	Arnt	50,54	dioxin	Arnt	CHEBI:28119	25242(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|nsubj|receptor	The dioxin receptor and its nuclear translocator -LRB- Arnt -RRB- in the rat brain .
11768231	0	dioxin	26,32	Aryl_hydrocarbon_receptor	0,25	dioxin	Aryl hydrocarbon receptor	CHEBI:28119	196	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|dep|receptor	Aryl_hydrocarbon_receptor / dioxin receptor in human monocytes and macrophages .
9464455	0	dioxin	43,49	CYP1A1	15,21	dioxin	CYP1A1	CHEBI:28119	13076(Tax:10090)	Chemical	Gene	inducibility|nmod|START_ENTITY inducibility|compound|END_ENTITY	Sensitivity of CYP1A1 mRNA inducibility by dioxin is the same in Cyp1a2 -LRB- + / + -RRB- wild-type and Cyp1a2 -LRB- - / - -RRB- null mutant mice .
1313028	0	dioxin	27,33	Cyp1a-1	92,99	dioxin	Cyp1a-1	CHEBI:28119	13076(Tax:10090)	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Phorbol_esters inhibit the dioxin receptor-mediated transcriptional activation of the mouse Cyp1a-1 and Cyp1a-2 genes by 2,3,7,8-tetrachlorodibenzo-p-dioxin .
17998243	0	dioxin	123,129	VDAC2	185,190	dioxin	VDAC2	CHEBI:28119	83531(Tax:10116)	Chemical	Gene	action|compound|START_ENTITY action|nmod|END_ENTITY	Analysis of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced proteome changes in 5L rat hepatoma cells reveals novel targets of dioxin action including the mitochondrial apoptosis regulator VDAC2 .
23426015	0	dioxin	24,30	acetylcholinesterase	43,63	dioxin	acetylcholinesterase	CHEBI:28119	43	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|compound|END_ENTITY	AhR-mediated effects of dioxin on neuronal acetylcholinesterase expression in vitro .
10913616	0	dioxin	106,112	aryl_hydrocarbon_receptor	69,94	dioxin	aryl hydrocarbon receptor	CHEBI:28119	196	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Flavones and flavonols at dietary levels inhibit a transformation of aryl_hydrocarbon_receptor induced by dioxin .
15113147	0	dioxin	117,123	aryl_hydrocarbon_receptor	80,105	dioxin	aryl hydrocarbon receptor	CHEBI:28119	196	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Pigments in green tea leaves -LRB- Camellia sinensis -RRB- suppress transformation of the aryl_hydrocarbon_receptor induced by dioxin .
15630227	0	dioxin	84,90	aryl_hydrocarbon_receptor	47,72	dioxin	aryl hydrocarbon receptor	CHEBI:28119	25690(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Black tea extract suppresses transformation of aryl_hydrocarbon_receptor induced by dioxin .
15630228	0	dioxin	83,89	aryl_hydrocarbon_receptor	46,71	dioxin	aryl hydrocarbon receptor	CHEBI:28119	11622(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Anthocyan does not suppress transformation of aryl_hydrocarbon_receptor induced by dioxin .
15914907	0	dioxin	83,89	aryl_hydrocarbon_receptor	46,71	dioxin	aryl hydrocarbon receptor	CHEBI:28119	11622(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Anthocyans fail to suppress transformation of aryl_hydrocarbon_receptor induced by dioxin .
11068867	0	dioxin	11,17	collagenase-3	34,47	dioxin	collagenase-3	CHEBI:28119	171052(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|cells cells|amod|END_ENTITY	Effects of dioxin and estrogen on collagenase-3 in UMR 106-01 osteosarcoma cells .
18724896	0	dioxin	11,17	insulin-like_growth_factor_binding_protein_6	96,140	dioxin	insulin-like growth factor binding protein 6	CHEBI:28119	3489	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Effect of dioxin on apoptosis of osteogenic_sarcoma cells and regulation on gene expression of insulin-like_growth_factor_binding_protein_6 -RSB- .
15570619	0	dioxin	80,86	mPR	72,75	dioxin	mPR	CHEBI:28119	71904(Tax:10090)	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Transcriptional activation of the membrane-bound_progesterone_receptor -LRB- mPR -RRB- by dioxin , in endocrine-responsive tissues .
19182260	0	dioxin	11,17	vascular_endothelial_growth_factor	21,55	dioxin	vascular endothelial growth factor	CHEBI:28119	7422	Chemical	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Effects of dioxin on vascular_endothelial_growth_factor -LRB- VEGF -RRB- production in the retina associated with choroidal_neovascularization .
12646511	0	dioxins	203,210	CYP1B1	174,180	dioxins	CYP1B1	MESH:D004147	1545	Chemical	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	Aryl_hydrocarbon_hydroxylase represents CYP1B1 , and not CYP1A1 , in human freshly isolated white cells : trimodal distribution of Japanese population according to induction of CYP1B1 mRNA by environmental dioxins .
16115717	0	dioxins	112,119	aryl_hydrocarbon_receptor	75,100	dioxins	aryl hydrocarbon receptor	MESH:D004147	196	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Molokhia -LRB- Corchorus olitorius L. -RRB- extract suppresses transformation of the aryl_hydrocarbon_receptor induced by dioxins .
12039559	0	dioxygen	11,19	PHD1	47,51	dioxygen	PHD1	MESH:D010100	112398	Chemical	Gene	hydroxylase|amod|START_ENTITY hydroxylase|appos|END_ENTITY	The use of dioxygen by HIF prolyl hydroxylase -LRB- PHD1 -RRB- .
18375516	0	dioxygen	54,62	urate_oxidase	92,105	dioxygen	urate oxidase	MESH:D010100	391051	Chemical	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Oxygen pressurized X-ray crystallography : probing the dioxygen binding site in cofactorless urate_oxidase and implications for its catalytic mechanism .
6791687	0	dipalmitoyl	16,27	apolipoprotein_A-I	89,107	dipalmitoyl	apolipoprotein A-I	null	335	Chemical	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of dipalmitoyl - and dimyristoylphosphatidylcholines and their mixtures with apolipoprotein_A-I .
1993679	0	dipalmitoylphosphatidylcholine	57,87	Pulmonary_surfactant_protein_A	0,30	dipalmitoylphosphatidylcholine	Pulmonary surfactant protein A	MESH:D015060	653509	Chemical	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	Pulmonary_surfactant_protein_A -LRB- SP-A -RRB- specifically binds dipalmitoylphosphatidylcholine .
2516855	0	dipalmitoylphosphatidylcholine	45,75	apolipoprotein_A-I	21,39	dipalmitoylphosphatidylcholine	apolipoprotein A-I	MESH:D015060	335	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of human apolipoprotein_A-I with dipalmitoylphosphatidylcholine in vesicular and micellar complexes .
6809761	0	dipalmitoylphosphatidylcholine	10,40	apolipoprotein_A-I	86,104	dipalmitoylphosphatidylcholine	apolipoprotein A-I	MESH:D015060	335	Chemical	Gene	vesicle|amod|START_ENTITY Effect|nmod|vesicle curvature|nsubj|Effect curvature|nmod|reaction reaction|nmod|END_ENTITY	Effect of dipalmitoylphosphatidylcholine vesicle curvature on the reaction with human apolipoprotein_A-I .
9548588	0	dipalmitoylphosphatidylcholine	51,81	pulmonary_surfactant_protein_A	15,45	dipalmitoylphosphatidylcholine	pulmonary surfactant protein A	MESH:D015060	653509	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of pulmonary_surfactant_protein_A with dipalmitoylphosphatidylcholine and cholesterol at the air/water interface .
16759105	0	dipeptide	48,57	PEPT1	6,11	dipeptide	PEPT1	CHEBI:46761	6564	Chemical	Gene	distinguishes|nmod|START_ENTITY pharmacophore|iobj|distinguishes pharmacophore|nsubj|END_ENTITY	Human PEPT1 pharmacophore distinguishes between dipeptide transport and binding .
18758810	0	dipeptide	28,37	PEPT1	118,123	dipeptide	PEPT1	CHEBI:46761	117261(Tax:10116)	Chemical	Gene	hydrolysis|compound|START_ENTITY Inhibition|nmod|hydrolysis uncovers|nsubj|Inhibition uncovers|dobj|currents currents|nmod|END_ENTITY	Inhibition of intracellular dipeptide hydrolysis uncovers large outward transport currents of the peptide transporter PEPT1 in Xenopus oocytes .
9893960	0	dipeptide	15,24	PEPT1	96,101	dipeptide	PEPT1	CHEBI:46761	6564	Chemical	Gene	Conjugation|nmod|START_ENTITY enhances|nsubj|Conjugation enhances|nmod|transporter transporter|appos|END_ENTITY	Conjugation of dipeptide to fluorescent dyes enhances its affinity for a dipeptide transporter -LRB- PEPT1 -RRB- in human intestinal Caco-2 cells .
9893960	0	dipeptide	73,82	PEPT1	96,101	dipeptide	PEPT1	CHEBI:46761	6564	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Conjugation of dipeptide to fluorescent dyes enhances its affinity for a dipeptide transporter -LRB- PEPT1 -RRB- in human intestinal Caco-2 cells .
12679938	0	dipeptide	23,32	PepT1	46,51	dipeptide	PepT1	CHEBI:46761	6564	Chemical	Gene	transporter|amod|START_ENTITY regulation|nmod|transporter regulation|appos|END_ENTITY	Hormonal regulation of dipeptide transporter -LRB- PepT1 -RRB- in Caco-2 cells with normal and anoxia/reoxygenation management .
14669333	0	dipeptide	35,44	PepT1	58,63	dipeptide	PepT1	CHEBI:46761	117261(Tax:10116)	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Changes of biological functions of dipeptide transporter -LRB- PepT1 -RRB- and hormonal regulation in severe scald rats .
17081567	0	dipeptide	36,45	PepT1	59,64	dipeptide	PepT1	CHEBI:46761	117261(Tax:10116)	Chemical	Gene	transporter|amod|START_ENTITY Apoptosis|nmod|transporter Apoptosis|appos|END_ENTITY	Apoptosis and functional changes of dipeptide transporter -LRB- PepT1 -RRB- in the rat small intestine after traumatic_brain_injury .
24422538	0	dipeptide	26,35	PepT1	93,98	dipeptide	PepT1	CHEBI:46761	6564	Chemical	Gene	START_ENTITY|nmod|nitric_oxide nitric_oxide|acl|donating donating|nmod|END_ENTITY	Combination of amino_acid / dipeptide with nitric_oxide donating oleanolic_acid derivatives as PepT1 targeting antitumor prodrugs .
9882198	2	dipeptide	200,209	PepT1	298,303	dipeptide	PepT1	CHEBI:46761	117261(Tax:10116)	Chemical	Gene	configuration|nmod|START_ENTITY mimics|dobj|configuration molecule|acl:relcl|mimics 4-Aminomethylbenzoic_acid|appos|molecule inhibits|nsubj|4-Aminomethylbenzoic_acid inhibits|nmod|expressing expressing|dobj|END_ENTITY	4-Aminomethylbenzoic_acid , a molecule which mimics the special configuration of a dipeptide , competitively inhibits peptide influx in both Xenopus_Laevis oocytes expressing rabbit PepT1 and through PepT1 in rat renal brush border membrane vesicles .
19612975	0	dipeptide	107,116	PepT2	0,5	dipeptide	PepT2	CHEBI:46761	6565	Chemical	Gene	START_ENTITY|nsubj|expression expression|amod|END_ENTITY	PepT2 transporter protein expression in human neoplastic glial cells and mediation of fluorescently tagged dipeptide derivative beta-Ala-Lys-Nepsilon-7-amino-4-methyl-coumarin-3-acetic_acid accumulation .
19434858	0	dipeptide	84,93	Pept1	43,48	dipeptide	Pept1	CHEBI:46761	56643(Tax:10090)	Chemical	Gene	absorption|amod|START_ENTITY reduces|dobj|absorption reduces|nsubj|disruption disruption|nmod|gene gene|compound|END_ENTITY	Targeted disruption of peptide transporter Pept1 gene in mice significantly reduces dipeptide absorption in intestine .
1404233	0	dipeptide	39,48	Renin	0,5	dipeptide	Renin	CHEBI:46761	102122446	Chemical	Gene	mimetics|amod|START_ENTITY containing|dobj|mimetics inhibitors|xcomp|containing inhibitors|nsubj|END_ENTITY	Renin inhibitors containing new P1-P1 ' dipeptide mimetics with heterocycles in P1 ' .
2002469	0	dipeptide	63,72	Renin	0,5	dipeptide	Renin	CHEBI:46761	5972	Chemical	Gene	mimetics|amod|START_ENTITY containing|dobj|mimetics inhibitors|xcomp|containing inhibitors|nsubj|END_ENTITY	Renin inhibitors containing conformationally restricted P1-P1 ' dipeptide mimetics .
2404121	0	dipeptide	26,35	Renin	0,5	dipeptide	Renin	CHEBI:46761	5972	Chemical	Gene	analogues|amod|START_ENTITY inhibitors|advcl|analogues inhibitors|nsubj|END_ENTITY	Renin inhibitors based on dipeptide analogues .
3312604	0	dipeptide	32,41	Renin	0,5	dipeptide	Renin	CHEBI:46761	5972	Chemical	Gene	analogues|compound|START_ENTITY inhibitors|advcl|analogues inhibitors|nsubj|END_ENTITY	Renin inhibitors based on novel dipeptide analogues .
12598410	0	dipeptide	25,34	VIP	65,68	dipeptide	VIP	CHEBI:46761	7432	Chemical	Gene	transport|compound|START_ENTITY transport|nmod|END_ENTITY	Inhibition of intestinal dipeptide transport by the neuropeptide VIP is an anti-absorptive effect via the VPAC1_receptor in a human enterocyte-like cell line -LRB- Caco-2 -RRB- .
8956326	0	dipeptide	6,15	hPEPT1	29,35	dipeptide	hPEPT1	CHEBI:46761	6564	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Human dipeptide transporter , hPEPT1 , stably transfected into Chinese_hamster ovary cells .
9790685	0	dipeptide	31,40	hPEPT1	54,60	dipeptide	hPEPT1	CHEBI:46761	6564	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Membrane topology of the human dipeptide transporter , hPEPT1 , determined by epitope insertions .
14532279	0	dipeptide	43,52	hPepT1	65,71	dipeptide	hPepT1	CHEBI:46761	6564	Chemical	Gene	transporter|amod|START_ENTITY segment|nmod|transporter Analysis|nmod|segment END_ENTITY|nsubj|Analysis	Analysis of transmembrane segment 7 of the dipeptide transporter hPepT1 by cysteine-scanning mutagenesis .
9735340	0	dipeptide	108,117	hPepT1	131,137	dipeptide	hPepT1	CHEBI:46761	6564	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Molecular identification of a role for tyrosine 167 in the function of the human intestinal proton - coupled dipeptide transporter -LRB- hPepT1 -RRB- .
2034668	0	dipeptide	45,54	neurophysin_II	30,44	dipeptide	neurophysin II	CHEBI:46761	280728(Tax:9913)	Chemical	Gene	START_ENTITY|nsubj|structure structure|nmod|END_ENTITY	Crystal structure of a bovine neurophysin_II dipeptide complex at 2.8 A determined from the single-wavelength anomalous scattering signal of an incorporated iodine atom .
20627594	0	dipeptide	63,72	prolyl_oligopeptidase	14,35	dipeptide	prolyl oligopeptidase	CHEBI:46761	5550	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of prolyl_oligopeptidase with a synthetic unnatural dipeptide .
20635532	0	dipeptide	36,45	renin	14,19	dipeptide	renin	CHEBI:46761	5972	Chemical	Gene	replacements|amod|START_ENTITY inhibitors|nmod|replacements inhibitors|nsubj|END_ENTITY	New potential renin inhibitors with dipeptide replacements in the molecule .
2666609	0	dipeptide	66,75	renin	17,22	dipeptide	renin	CHEBI:46761	5972	Chemical	Gene	inhibitor|dep|START_ENTITY inhibitor|compound|END_ENTITY	An orally active renin inhibitor : cyclohexylnorstatine-containing dipeptide -LRB- KRI-1314 -RRB- .
7954938	0	dipeptide	10,19	tissue-type_plasminogen_activator	68,101	dipeptide	tissue-type plasminogen activator	CHEBI:46761	25692(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|release release|nmod|END_ENTITY	Synthetic dipeptide , N-stearoyl-D-Ser-L-Pro-OEt , induces release of tissue-type_plasminogen_activator in cultured cells and in experimental animals .
3304296	0	dipeptide_glycol	17,33	renin	34,39	dipeptide glycol	renin	null	5972	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Enhanced potency dipeptide_glycol renin inhibitors : studies in vitro and in the conscious rhesus .
2999395	0	dipeptides	78,88	Angiotensin_converting_enzyme	0,29	dipeptides	Angiotensin converting enzyme	MESH:D004151	1636	Chemical	Gene	inhibitors|dep|START_ENTITY inhibitors|amod|END_ENTITY	Angiotensin_converting_enzyme inhibitors : N-substituted_D-glutamic_acid gamma dipeptides .
20599705	0	dipeptides	43,53	T2R1	22,26	dipeptides	T2R1	MESH:D004151	50834	Chemical	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	Bitter taste receptor T2R1 is activated by dipeptides and tripeptides .
24193022	0	dipeptides	72,82	dipeptidyl_peptidase_IV	14,37	dipeptides	dipeptidyl peptidase IV	MESH:D004151	1803	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of dipeptidyl_peptidase_IV -LRB- DPP-IV -RRB- by tryptophan containing dipeptides .
10052978	0	dipeptides	27,37	p56lck	71,77	dipeptides	p56lck	MESH:D004151	3932	Chemical	Gene	START_ENTITY|nmod|domain domain|amod|END_ENTITY	Phosphotyrosine-containing dipeptides as high-affinity ligands for the p56lck SH2 domain .
3318552	0	dipeptidyl	69,79	cathepsin_B	109,120	dipeptidyl	cathepsin B	null	281105(Tax:9913)	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Chromophoric and fluorophoric peptide substrates cleaved through the dipeptidyl carboxypeptidase activity of cathepsin_B .
20850545	0	dipeptidyl_glyoxal	101,119	cathepsin_L	69,80	dipeptidyl glyoxal	cathepsin L	null	1514	Chemical	Gene	basis|nmod|START_ENTITY basis|nmod|END_ENTITY	Structural basis for reversible and irreversible inhibition of human cathepsin_L by their respective dipeptidyl_glyoxal and diazomethylketone inhibitors .
11741472	0	dipeptidyl_nitriles	18,37	cathepsin_B	76,87	dipeptidyl nitriles	cathepsin B	null	1508	Chemical	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of dipeptidyl_nitriles as potent and selective inhibitors of cathepsin_B through structure-based drug design .
12651003	0	dipetarudin	58,69	thrombin	86,94	dipetarudin	thrombin	null	2147	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Cloning , purification and biochemical characterization of dipetarudin , a new chimeric thrombin inhibitor .
20095801	0	diphencyprone	11,24	Bcl-2	42,47	diphencyprone	Bcl-2	MESH:C029402	596	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|protein protein|compound|END_ENTITY	Effects of diphencyprone on expression of Bcl-2 protein in patients with alopecia areata .
7071092	0	diphenhydramine	10,25	histidine_decarboxylase	61,84	diphenhydramine	histidine decarboxylase	MESH:D004155	24443(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of diphenhydramine on stress-induced changes in brain histidine_decarboxylase activity , histamine and plasma corticosterone levels .
9159041	0	diphenyl-dimethyl-dicarboxylate	14,45	cyclosporine-A	49,63	diphenyl-dimethyl-dicarboxylate	cyclosporine-A	MESH:C041398	1161	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|level level|amod|END_ENTITY	The effect of diphenyl-dimethyl-dicarboxylate on cyclosporine-A blood level in kidney transplants with chronic hepatitis .
21259066	0	diphenyl-ether	36,50	protoporphyrinogen_oxidase	54,80	diphenyl-ether	protoporphyrinogen oxidase	MESH:C031538	5498	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Structure-activity relationships of diphenyl-ether as protoporphyrinogen_oxidase inhibitors : insights from computational simulations .
8531232	0	diphenyl_dimethyl_dicarboxylate	11,42	ovalbumin	64,73	diphenyl dimethyl dicarboxylate	ovalbumin	MESH:C041398	282665(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|acl|END_ENTITY	Effects of diphenyl_dimethyl_dicarboxylate on oral tolerance to ovalbumin in mice .
21030914	0	diphenyl_diselenide	13,32	thioredoxin_reductase	58,79	diphenyl diselenide	thioredoxin reductase	MESH:C061132	25824	Chemical	Gene	Reduction|nmod|START_ENTITY Reduction|nmod|END_ENTITY	Reduction of diphenyl_diselenide and analogs by mammalian thioredoxin_reductase is independent of their gluthathione peroxidase-like activity : a possible novel pathway for their antioxidant activity .
8645710	0	diphenyl_phosphonate_esters	18,45	dipeptidyl_peptidase_IV	77,100	diphenyl phosphonate esters	dipeptidyl peptidase IV	null	1803	Chemical	Gene	START_ENTITY|dep|inhibitors inhibitors|nmod|END_ENTITY	Dipeptide-derived diphenyl_phosphonate_esters : mechanism-based inhibitors of dipeptidyl_peptidase_IV .
11881994	0	diphenyl_sulfides	12,29	serotonin_transporter	43,64	diphenyl sulfides	serotonin transporter	null	6532	Chemical	Gene	START_ENTITY|nmod|ligands ligands|compound|END_ENTITY	Substituted diphenyl_sulfides as selective serotonin_transporter ligands : synthesis and in vitro evaluation .
25043383	0	diphenyleneiodonium	13,32	NADPH_oxidase	53,66	diphenyleneiodonium	NADPH oxidase	MESH:C007517	1536	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Subpicomolar diphenyleneiodonium inhibits microglial NADPH_oxidase with high specificity and shows great potential as a therapeutic agent for neurodegenerative_diseases .
4904710	0	diphenylhydantoin	35,52	insulin	14,21	diphenylhydantoin	insulin	MESH:D010672	3630	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of insulin secretion by diphenylhydantoin in the isolated perfused pancreas .
4918328	0	diphenylhydantoin	48,65	insulin	27,34	diphenylhydantoin	insulin	MESH:D010672	3630	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|inhibition inhibition|nmod|END_ENTITY	The in vitro inhibition of insulin secretion by diphenylhydantoin .
596101	0	diphenylhydantoin	10,27	insulin	43,50	diphenylhydantoin	insulin	MESH:D010672	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|patterns patterns|nmod|secretion secretion|compound|END_ENTITY	Effect of diphenylhydantoin on patterns of insulin secretion in obese subjects .
942132	0	diphenylhydantoin	81,98	insulin	36,43	diphenylhydantoin	insulin	MESH:D010672	3630	Chemical	Gene	-RSB-|amod|START_ENTITY treated|nmod|-RSB- Effect|acl|treated Effect|nmod|END_ENTITY	-LSB- Effect of tolbutamide on plasmatic insulin and glucose in children treated with diphenylhydantoin -LRB- author 's transl -RRB- -RSB- .
24389511	0	diphenylmethylamine	63,82	Akt1	104,108	diphenylmethylamine	Akt1	null	207	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Structure-based design , synthesis and biological evaluation of diphenylmethylamine derivatives as novel Akt1 inhibitors .
11911205	0	diphenylmethylenepiperidines	34,62	5-HT2B	66,72	diphenylmethylenepiperidines	5-HT2B	null	29581(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|receptors receptors|nummod|END_ENTITY	Influence of pH on the binding of diphenylmethylenepiperidines by 5-HT2B receptors in rat stomach fundus .
12628665	0	diphenylnaphthyl_propylene	60,86	estrogen_receptor	102,119	diphenylnaphthyl propylene	estrogen receptor	MESH:C478570	2099	Chemical	Gene	START_ENTITY|acl|ligand ligand|nmod|END_ENTITY	De novo design , synthesis and evaluation of a non-steroidal diphenylnaphthyl_propylene ligand for the estrogen_receptor .
8287315	0	diphosphonates	168,182	parathyroid_hormone	73,92	diphosphonates	parathyroid hormone	MESH:D004164	5741	Chemical	Gene	Decrease|nmod|START_ENTITY Decrease|nmod|release release|amod|END_ENTITY	Decrease of serum calcium concentration and lost influence of calcium on parathyroid_hormone release in a patient with primary_hyperparathyroidism after treatment with diphosphonates .
3597406	0	diphytanoyl_phosphatidylcholine	54,85	lecithin-cholesterol_acyltransferase	14,50	diphytanoyl phosphatidylcholine	lecithin-cholesterol acyltransferase	MESH:C021016	3931	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of lecithin-cholesterol_acyltransferase by diphytanoyl_phosphatidylcholine .
9317120	7	diproline	1279,1288	CD28	1298,1302	diproline	CD28	null	940	Chemical	Gene	motif|compound|START_ENTITY motif|nmod|END_ENTITY	In addition , peptides corresponding to the N-terminal diproline motif of CD28 activated the tyrosine kinase activity of Itk to levels similar to those observed following Ab-mediated cross-linking of CD28 .
1671823	0	diprotin_B	33,43	dipeptidyl_peptidase_IV	86,109	diprotin B	dipeptidyl peptidase IV	MESH:C041446	1803	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Are diprotin_A _ -LRB- Ile-Pro-Ile -RRB- and diprotin_B -LRB- Val-Pro-Leu -RRB- inhibitors or substrates of dipeptidyl_peptidase_IV ?
16247709	0	dipyridamole	16,28	BCRP	0,4	dipyridamole	BCRP	MESH:D004176	9429	Chemical	Gene	transports|dobj|START_ENTITY transports|nsubj|END_ENTITY	BCRP transports dipyridamole and is inhibited by calcium channel blockers .
25430877	0	dipyrone	49,57	CB1	12,15	dipyrone	CB1	MESH:D004177	1268	Chemical	Gene	effects|nmod|START_ENTITY mediate|dobj|effects mediate|nsubj|receptors receptors|compound|END_ENTITY	Cannabinoid CB1 receptors mediate the effects of dipyrone .
25178686	0	diquafosol	67,77	P2Y2	31,35	diquafosol	P2Y2	MESH:C403315	485203(Tax:9615)	Chemical	Gene	START_ENTITY|nsubj|expression expression|nmod|receptor receptor|compound|END_ENTITY	Conjunctival expression of the P2Y2 receptor and the effects of 3 % diquafosol ophthalmic solution in dogs .
9013373	0	dirithromycin	10,23	CYP3A	33,38	dirithromycin	CYP3A	MESH:C053853	1576	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of dirithromycin on human CYP3A in vitro and on pharmacokinetics and pharmacodynamics of terfenadine in vivo .
22484948	0	disaccharides	32,45	insulin	51,58	disaccharides	insulin	MESH:D004187	3630	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Screening and identification of disaccharides with insulin mimetic activity against L6 cells .
1906238	0	disodium_aurothiomalate	13,36	xanthine_dehydrogenase	58,80	disodium aurothiomalate	xanthine dehydrogenase	CHEBI:35864	7498	Chemical	Gene	START_ENTITY|nmod|activities activities|nmod|END_ENTITY	Influence of disodium_aurothiomalate on the activities of xanthine_dehydrogenase and xanthine oxidase in endothelial cells .
6439565	0	disodium_chromoglycate	10,32	platelet_activating_factor	82,108	disodium chromoglycate	platelet activating factor	null	9768	Chemical	Gene	Effect|nmod|START_ENTITY induced|nsubj|Effect induced|nmod|END_ENTITY	Effect of disodium_chromoglycate on changes in nasal airway resistance induced by platelet_activating_factor .
12803546	0	disodium_cromoglycate	52,73	Hsp90	0,5	disodium cromoglycate	Hsp90	MESH:D004205	3320	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Hsp90 is a direct target of the anti-allergic drugs disodium_cromoglycate and amlexanox .
21314600	0	distamycin	13,23	histone_H1	74,84	distamycin	histone H1	MESH:C030000	24437(Tax:10116)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of distamycin , chromomycin , and UV-irradiation on extraction of histone_H1 from rat liver nuclei by polyglutamic_acid .
22676210	0	disubstituted_dibenzosuberones	54,84	p38_mitogen_activated_protein_kinase	130,166	disubstituted dibenzosuberones	p38 mitogen activated protein kinase	null	1432	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Design , synthesis , and biological evaluation of novel disubstituted_dibenzosuberones as highly potent and selective inhibitors of p38_mitogen_activated_protein_kinase .
3707978	0	disulfide	73,82	Conformational_studies_of_lipoprotein_B_and_apolipoprotein_B	0,60	disulfide	Conformational studies of lipoprotein B and apolipoprotein B	CHEBI:48343	338	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|dep|effects	Conformational_studies_of_lipoprotein_B_and_apolipoprotein_B : effects of disulfide reducing agents , sulfhydryl blocking agent , denaturing agents , pH and storage .
9352906	0	disulfide	29,38	DsbC	55,59	disulfide	DsbC	CHEBI:48343	13905684	Chemical	Gene	isomerase|amod|START_ENTITY isomerase|appos|END_ENTITY	Reduction of the periplasmic disulfide bond isomerase , DsbC , occurs by passage of electrons from cytoplasmic thioredoxin .
16699035	0	disulfide	72,81	Env	128,131	disulfide	Env	CHEBI:48343	17276(Tax:10090)	Chemical	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Furin cleavage potentiates the membrane fusion-controlling intersubunit disulfide bond isomerization activity of leukemia virus Env .
10982384	0	disulfide	93,102	Ero1p	76,81	disulfide	Ero1p	CHEBI:48343	854909(Tax:4932)	Chemical	Gene	formation|compound|START_ENTITY END_ENTITY|nmod|formation	Two pairs of conserved cysteines are required for the oxidative activity of Ero1p in protein disulfide bond formation in the endoplasmic reticulum .
13678526	2	disulfide	286,295	Ero1p	328,333	disulfide	Ero1p	CHEBI:48343	843560(Tax:3702)	Chemical	Gene	isomerase|compound|START_ENTITY isomerase|acl:relcl|requires requires|dobj|END_ENTITY	In yeast , the oxidative folding of secretory pathway proteins is catalyzed by protein disulfide isomerase -LRB- PDI -RRB- , which requires Ero1p -LRB- endoplasmic reticulum oxidoreductin -RRB- for its own oxidation .
20348090	0	disulfide	45,54	Ero1p	28,33	disulfide	Ero1p	CHEBI:48343	854909(Tax:4932)	Chemical	Gene	START_ENTITY|nsubj|activity activity|nmod|END_ENTITY	Oxidative activity of yeast Ero1p on protein disulfide isomerase and related oxidoreductases of the endoplasmic reticulum .
20348090	7	disulfide	1171,1180	Ero1p	1101,1106	disulfide	Pdi1p	CHEBI:48343	850314(Tax:4932)	Chemical	Gene	lacking|dobj|START_ENTITY observed|xcomp|lacking observed|nmod|variant variant|amod|END_ENTITY	In particular , the amino-terminal domain of Pdi1p preferentially formed mixed disulfides with Ero1p in vivo , and we observed synthetic lethality between a temperature-sensitive Ero1p variant and mutant Pdi1p lacking the amino-terminal active-site disulfide .
11985703	0	disulfide	113,122	HNP-1	71,76	disulfide	HNP-1	CHEBI:48343	574045	Chemical	Gene	START_ENTITY|nsubj|activities activities|nmod|END_ENTITY	Antibacterial activities and conformations of synthetic alpha-defensin HNP-1 and analogs with one , two and three disulfide bridges .
821533	0	disulfide	39,48	J-chain	16,23	disulfide	J-chain	CHEBI:48343	3512	Chemical	Gene	START_ENTITY|nsubj|Localization Localization|nmod|END_ENTITY	Localization of J-chain and interchain disulfide bonds in a human F -LRB- c -RRB- 5mu-like fragment .
14529283	0	disulfide	44,53	NTPDase6	90,98	disulfide	NTPDase6	CHEBI:48343	955	Chemical	Gene	determination|amod|START_ENTITY determination|nmod|END_ENTITY	Bacterial expression , characterization , and disulfide bond determination of soluble human NTPDase6 -LRB- CD39L2 -RRB- nucleotidase : implications for structure and function .
16497834	0	disulfide	74,83	RB60	44,48	disulfide	RB60	CHEBI:48343	5727435(Tax:3055)	Chemical	Gene	reacts|nmod|START_ENTITY reacts|nsubj|END_ENTITY	The chloroplast protein_disulfide_isomerase RB60 reacts with a regulatory disulfide of the RNA-binding protein RB47 .
23828196	0	disulfide	55,64	Rv2969c	127,134	disulfide	Rv2969c	CHEBI:48343	888481(Tax:83332)	Chemical	Gene	properties|amod|START_ENTITY properties|nmod|END_ENTITY	Structure analysis of the extracellular domain reveals disulfide bond forming-protein properties of Mycobacterium_tuberculosis Rv2969c .
17914842	0	disulfide	17,26	SN2	13,16	disulfide	SN2	CHEBI:48343	92745	Chemical	Gene	START_ENTITY|nsubj|Mechanism Mechanism|nmod|END_ENTITY	Mechanism of SN2 disulfide bond cleavage by phosphorus nucleophiles .
19416874	0	disulfide	20,29	SOD1	15,19	disulfide	SOD1	CHEBI:48343	20655(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of mutant SOD1 disulfide oxidation and aggregation in the pathogenesis of familial_ALS .
14678831	0	disulfide	19,28	XPDIp	40,45	disulfide	XPDIp	CHEBI:48343	399040(Tax:8355)	Chemical	Gene	isomerase|compound|START_ENTITY isomerase|appos|END_ENTITY	Pancreatic protein disulfide isomerase -LRB- XPDIp -RRB- is an early marker for the exocrine lineage of the developing pancreas in Xenopus_laevis embryos .
9724530	0	disulfide	17,26	agouti-related_protein	40,62	disulfide	agouti-related protein	CHEBI:48343	181	Chemical	Gene	structure|amod|START_ENTITY structure|nmod|END_ENTITY	Determination of disulfide structure in agouti-related_protein -LRB- AGRP -RRB- by stepwise reduction and alkylation .
1733934	0	disulfide	4,13	basic_fibroblast_growth_factor	44,74	disulfide	basic fibroblast growth factor	CHEBI:48343	281161(Tax:9913)	Chemical	Gene	structure|amod|START_ENTITY structure|nmod|END_ENTITY	The disulfide structure of bovine pituitary basic_fibroblast_growth_factor .
11092861	0	disulfide	143,152	dsbA	169,173	disulfide	dsbA	CHEBI:48343	877731(Tax:208964)	Chemical	Gene	isomerase|amod|START_ENTITY isomerase|appos|END_ENTITY	Proteome analysis of the effect of mucoid conversion on global protein expression in Pseudomonas_aeruginosa_strain_PAO1 shows induction of the disulfide bond isomerase , dsbA .
12018622	0	disulfide	4,13	epidermal_growth_factor	37,60	disulfide	epidermal growth factor	CHEBI:48343	1950	Chemical	Gene	structure|amod|START_ENTITY structure|nmod|END_ENTITY	The disulfide structure of denatured epidermal_growth_factor : preparation of scrambled disulfide isomers .
12018622	0	disulfide	87,96	epidermal_growth_factor	37,60	disulfide	epidermal growth factor	CHEBI:48343	1950	Chemical	Gene	isomers|compound|START_ENTITY preparation|nmod|isomers structure|dep|preparation structure|nmod|END_ENTITY	The disulfide structure of denatured epidermal_growth_factor : preparation of scrambled disulfide isomers .
7721838	0	disulfide	4,13	epidermal_growth_factor	39,62	disulfide	epidermal growth factor	CHEBI:48343	1950	Chemical	Gene	pathway|amod|START_ENTITY pathway|nmod|END_ENTITY	The disulfide folding pathway of human epidermal_growth_factor .
3509954	0	disulfide	136,145	fibrinogen	166,176	disulfide	fibrinogen	CHEBI:48343	2244	Chemical	Gene	START_ENTITY|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Effect of peptides -- structural analogs of NH2-terminal sites of fibrin alpha - and beta-chains -- on specific binding of the NH2-terminal disulfide bond of fibrin with fibrinogen -RSB- .
26367307	0	disulfide	104,113	high_mobility_group_box_1	114,139	disulfide	high mobility group box 1	CHEBI:48343	15289(Tax:10090)	Chemical	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Toll-like_receptor_4 signaling : A common pathway for interactions between prooxidants and extracellular disulfide high_mobility_group_box_1 -LRB- HMGB1 -RRB- protein-coupled activation .
6995531	0	disulfide	92,101	human_placental_lactogen	47,71	disulfide	human placental lactogen	CHEBI:48343	3956	Chemical	Gene	formation|compound|START_ENTITY END_ENTITY|nmod|formation	Coupling of delta_5 ,3 - ketosteroid isomerase to human_placental_lactogen with intermolecular disulfide bond formation .
2332434	0	disulfide	4,13	lysosome-associated_membrane_protein_1	33,71	disulfide	lysosome-associated membrane protein 1	CHEBI:48343	16783(Tax:10090)	Chemical	Gene	structure|amod|START_ENTITY structure|nmod|END_ENTITY	The disulfide structure of mouse lysosome-associated_membrane_protein_1 .
6340679	0	disulfide	32,41	oxidoreductase	42,56	disulfide	oxidoreductase	CHEBI:48343	7296	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Identification of thiol : protein disulfide oxidoreductase activity in cultured human fibroblasts : dependence of enzyme activity on growth conditions .
9743619	0	disulfide	172,181	oxidoreductase	182,196	disulfide	oxidoreductase	CHEBI:48343	9538117	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Functional analysis of the Escherichia_coli genome using the sequence-to-structure-to-function paradigm : identification of proteins exhibiting the glutaredoxin/thioredoxin disulfide oxidoreductase activity .
9663937	0	disulfide	65,74	reductase	75,84	disulfide	reductase	CHEBI:48343	547911(Tax:3847)	Chemical	Gene	START_ENTITY|dobj|activity activity|amod|END_ENTITY	A protein disulfide-thiol interchange protein with NADH : protein disulfide reductase -LRB- NADH oxidase -RRB- activity as a molecular target for low levels of exposure to organic solvents in plant growth .
7295733	0	disulfide	72,81	thioltransferase	98,114	disulfide	thioltransferase	CHEBI:48343	2745	Chemical	Gene	oxidoreductase|amod|START_ENTITY oxidoreductase|appos|END_ENTITY	Characterization and partial purification of a cytoplasmic glutathione : disulfide oxidoreductase -LRB- thioltransferase -RRB- from adenohypophysis .
7788295	0	disulfide	51,60	thioredoxin	28,39	disulfide	thioredoxin	CHEBI:48343	7295	Chemical	Gene	complex|amod|START_ENTITY END_ENTITY|nmod|complex	Solution structure of human thioredoxin in a mixed disulfide intermediate complex with its target peptide from the transcription factor NF_kappa_B .
7876079	1	disulfide	109,118	thioredoxin	97,108	disulfide	thioredoxin	CHEBI:48343	7295	Chemical	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Loss of thioredoxin disulfide reductase activity is accompanied by a large increase in NADPH oxidase activity .
3654604	0	disulfide	15,24	tumor_necrosis_factor-alpha	46,73	disulfide	tumor necrosis factor-alpha	CHEBI:48343	7124	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of single disulfide in recombinant human tumor_necrosis_factor-alpha .
7045094	0	disulfides	8,18	insulin_receptor	51,67	disulfides	insulin receptor	MESH:D004220	24954(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of disulfides in the subunit structure of the insulin_receptor .
9375378	1	disulfides	122,132	thioltransferase	161,177	disulfides	thioltransferase	MESH:D004220	515416(Tax:9913)	Chemical	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of cytosolic enzymes by disulfides and its redox regulation by thioltransferase .
15173163	0	disulfides	23,33	vitronectin	83,94	disulfides	vitronectin	MESH:D004220	7448	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Assignment of the four disulfides in the N-terminal somatomedin_B domain of native vitronectin isolated from human plasma .
10348802	0	disulfiram	20,30	P-450	127,132	disulfiram	P-450	MESH:D004221	1555	Chemical	Gene	effects|compound|START_ENTITY Lack|nmod|effects Lack|dep|evidence evidence|nmod|specificity specificity|nmod|END_ENTITY	Lack of single-dose disulfiram effects on cytochrome P-450 2C9 , 2C19 , 2D6 , and 3A4 activities : evidence for specificity toward P-450 2E1 .
10348802	0	disulfiram	20,30	P-450	53,58	disulfiram	P-450	MESH:D004221	1555	Chemical	Gene	effects|compound|START_ENTITY effects|nmod|END_ENTITY	Lack of single-dose disulfiram effects on cytochrome P-450 2C9 , 2C19 , 2D6 , and 3A4 activities : evidence for specificity toward P-450 2E1 .
9756035	0	disulfiram	162,172	P-450	145,150	disulfiram	P-450	MESH:D004221	1555	Chemical	Gene	bioactivation|compound|START_ENTITY enzymes|nmod|bioactivation enzymes|compound|END_ENTITY	Identification of the human P-450 enzymes responsible for the sulfoxidation and thiono-oxidation of diethyldithiocarbamate_methyl_ester : role of P-450 enzymes in disulfiram bioactivation .
9756035	0	disulfiram	162,172	P-450	28,33	disulfiram	P-450	MESH:D004221	1555	Chemical	Gene	bioactivation|compound|START_ENTITY enzymes|nmod|bioactivation role|nmod|enzymes Identification|dep|role Identification|nmod|enzymes enzymes|compound|END_ENTITY	Identification of the human P-450 enzymes responsible for the sulfoxidation and thiono-oxidation of diethyldithiocarbamate_methyl_ester : role of P-450 enzymes in disulfiram bioactivation .
2822291	0	disulfiram	21,31	alcohol_dehydrogenase	46,67	disulfiram	alcohol dehydrogenase	MESH:D004221	10327	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|amod|END_ENTITY	Inhibitory effect of disulfiram -LRB- Antabuse -RRB- on alcohol_dehydrogenase activity .
10974203	0	disulfiram	8,18	aldehyde_dehydrogenase	73,95	disulfiram	aldehyde dehydrogenase	MESH:D004221	25375(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY END_ENTITY|nsubj|Role	Role of disulfiram in the in vitro inhibition of rat liver mitochondrial aldehyde_dehydrogenase .
315864	0	disulfiram	47,57	dopamine-beta-hydroxylase	10,35	disulfiram	dopamine-beta-hydroxylase	MESH:D004221	1621	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Effect of dopamine-beta-hydroxylase inhibitor -LRB- disulfiram -RRB- on the response of adenohypophysis , serum ceruloplasmin and hypothalamic ascorbic_acid to estradiol treatment .
345861	0	disulfiram	66,76	dopamine_beta-hydroxylase	4,29	disulfiram	dopamine beta-hydroxylase	MESH:D004221	1621	Chemical	Gene	predict|nmod|START_ENTITY predict|nsubj|levels levels|amod|END_ENTITY	Can dopamine_beta-hydroxylase levels predict adverse reactions to disulfiram ?
8904971	0	disulfiram	80,90	transferrin	23,34	disulfiram	transferrin	MESH:D004221	7018	Chemical	Gene	therapy|compound|START_ENTITY END_ENTITY|nmod|therapy	Carbohydrate-deficient transferrin and gamma-glutamyl transferase levels during disulfiram therapy .
19088833	0	disulfiram	14,24	transforming_growth_factor-beta2	46,78	disulfiram	transforming growth factor-beta2	MESH:D004221	421352(Tax:9031)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|expression expression|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Influence of disulfiram on the expression of transforming_growth_factor-beta2 in form-deprived eyes in chicks -RSB- .
19331341	0	disulfonate	100,111	PSGL-1	144,150	disulfonate	PSGL-1	null	6404	Chemical	Gene	analog|amod|START_ENTITY analog|nmod|END_ENTITY	Trichloroethyl group as a protecting group for sulfonates and its application to the synthesis of a disulfonate analog of the tyrosine sulfated PSGL-1 -LRB- 43-50 -RRB- peptide .
23533690	6	disulphide	924,934	PDI	946,949	disulphide	PDI	null	5034	Chemical	Gene	isomerase|compound|START_ENTITY isomerase|appos|END_ENTITY	We also speculate that an ER chaperone protein disulphide isomerase -LRB- PDI -RRB- could play a key role in this dysregulation .
1438167	0	disulphide	12,22	prolactin	61,70	disulphide	prolactin	null	280901(Tax:9913)	Chemical	Gene	function|amod|START_ENTITY function|nmod|END_ENTITY	Analysis of disulphide bridge function in recombinant bovine prolactin using site-specific mutagenesis and renaturation under mild alkaline conditions : a crucial role for the central disulphide bridge in the mitogenic activity of the hormone .
1871042	0	ditekiren	90,99	renin	109,114	ditekiren	renin	MESH:C050898	5972	Chemical	Gene	formulation|nmod|START_ENTITY compatibility|nmod|formulation evaluation|nmod|compatibility pseudopeptide|nmod|evaluation pseudopeptide|nsubj|inhibitor inhibitor|compound|END_ENTITY	In vitro evaluation of the plasma and blood compatibility of a parenteral formulation for ditekiren , a novel renin inhibitor pseudopeptide .
2066983	0	ditekiren	114,123	renin	68,73	ditekiren	renin	MESH:C050898	5972	Chemical	Gene	analogues|nmod|START_ENTITY application|nmod|analogues Determination|dep|application Determination|nmod|constants constants|nmod|inhibitors inhibitors|compound|END_ENTITY	Determination of dissociation constants of high affinity -LRB- pM -RRB- human renin inhibitors : application to analogues of ditekiren -LRB- U-71 ,038 -RRB- .
2187899	0	ditekiren	17,26	renin	30,35	ditekiren	renin	MESH:C050898	5972	Chemical	Gene	START_ENTITY|appos|peptide peptide|amod|END_ENTITY	Determination of ditekiren , a renin inhibitor peptide , in monkey serum using high-performance liquid chromatography with solid-phase extraction .
8095217	0	ditekiren	34,43	renin	57,62	ditekiren	renin	MESH:C050898	24715(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Hepatic elimination in the rat of ditekiren -LRB- U-71038 -RRB- , a renin inhibitor pseudohexapeptide .
14745177	0	diterpene_aphidicolin	62,83	DNA_polymerase_alpha	109,129	diterpene aphidicolin	DNA polymerase alpha	null	5422	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Cloning of a gene cluster responsible for the biosynthesis of diterpene_aphidicolin , a specific inhibitor of DNA_polymerase_alpha .
18593583	0	diterpene_kahweol	11,28	heme_oxygenase-1	37,53	diterpene kahweol	heme oxygenase-1	null	3162	Chemical	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	The coffee diterpene_kahweol induces heme_oxygenase-1 via the PI3K and p38/Nrf2 pathway to protect human dopaminergic neurons from 6-hydroxydopamine-derived oxidative stress .
21353547	0	diterpenes	44,54	HIF-2a	72,78	diterpenes	HIF-2a	MESH:D004224	2034	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Identification and evaluation of soft coral diterpenes as inhibitors of HIF-2a induced gene expression .
15993607	0	diterpenoid	5,16	Cdc25B	31,37	diterpenoid	Cdc25B	CHEBI:23849	994	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Four diterpenoid inhibitors of Cdc25B phosphatase from a marine anemone .
15114495	0	diterpenoid	6,17	acetylcholinesterase	18,38	diterpenoid	acetylcholinesterase	CHEBI:23849	43	Chemical	Gene	START_ENTITY|dobj|inhibitors inhibitors|amod|END_ENTITY	Novel diterpenoid acetylcholinesterase inhibitors from Salvia miltiorhiza .
23273218	0	diterpenoids	14,26	PTP1B	32,37	diterpenoids	PTP1B	MESH:D004224	5770	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|compound|END_ENTITY	Unprecedented diterpenoids as a PTP1B inhibitor from the Hainan soft coral Sarcophyton trocheliophorum Marenzeller .
23736977	0	diterpenoids	104,116	estrogen_sulfotransferase	22,47	diterpenoids	estrogen sulfotransferase	MESH:D004224	6783	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	New diterpenoids with estrogen_sulfotransferase inhibitory activity from Leonurus sibiricus L. Four new diterpenoids -LRB- 1-4 -RRB- , along with eight known diterpenoids -LRB- 5-12 -RRB- were isolated from the acetone extract of Leonurus herb -LRB- aerial parts of Leonurus sibiricus L. -RRB- .
23736977	0	diterpenoids	147,159	estrogen_sulfotransferase	22,47	diterpenoids	estrogen sulfotransferase	MESH:D004224	6783	Chemical	Gene	along|nmod|START_ENTITY activity|advmod|along activity|amod|END_ENTITY	New diterpenoids with estrogen_sulfotransferase inhibitory activity from Leonurus sibiricus L. Four new diterpenoids -LRB- 1-4 -RRB- , along with eight known diterpenoids -LRB- 5-12 -RRB- were isolated from the acetone extract of Leonurus herb -LRB- aerial parts of Leonurus sibiricus L. -RRB- .
23736977	0	diterpenoids	4,16	estrogen_sulfotransferase	22,47	diterpenoids	estrogen sulfotransferase	MESH:D004224	6783	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	New diterpenoids with estrogen_sulfotransferase inhibitory activity from Leonurus sibiricus L. Four new diterpenoids -LRB- 1-4 -RRB- , along with eight known diterpenoids -LRB- 5-12 -RRB- were isolated from the acetone extract of Leonurus herb -LRB- aerial parts of Leonurus sibiricus L. -RRB- .
9315628	0	dithiocarbamate	53,68	p53	84,87	dithiocarbamate	p53	null	7157	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Regulation of p53 by metal ions and by antioxidants : dithiocarbamate down-regulates p53 DNA-binding activity by increasing the intracellular level of copper .
12901862	0	dithiocarbamates	61,77	11_beta-hydroxysteroid_dehydrogenase_type_2	14,57	dithiocarbamates	11 beta-hydroxysteroid dehydrogenase type 2	null	3291	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of 11_beta-hydroxysteroid_dehydrogenase_type_2 by dithiocarbamates .
23744253	0	dithiocarbamates	65,81	NF_kappa_B	15,25	dithiocarbamates	NF kappa B	null	4790	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of NF_kappa_B in potentiated effect of Mn-containing dithiocarbamates on MPP -LRB- + -RRB- induced cell death .
9248629	0	dithiocarbamates	42,58	Thyroid_peroxidase	0,18	dithiocarbamates	Thyroid peroxidase	null	7173	Chemical	Gene	target|nmod|START_ENTITY END_ENTITY|nmod|target	Thyroid_peroxidase as toxicity target for dithiocarbamates .
10762665	0	dithiocarbamates	20,36	nuclear_factor-kappaB	56,77	dithiocarbamates	nuclear factor-kappaB	null	4790	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Biphasic effects of dithiocarbamates on the activity of nuclear_factor-kappaB .
8968040	0	dithiolethiones	85,100	heme_oxygenase-1	21,37	dithiolethiones	heme oxygenase-1	null	24451(Tax:10116)	Chemical	Gene	rats|nmod|START_ENTITY Induction|nmod|rats Induction|nmod|END_ENTITY	Induction of hepatic heme_oxygenase-1 and ferritin in rats by cancer chemopreventive dithiolethiones .
14500751	7	dithiothreitol	1214,1228	TH	1268,1270	dithiothreitol	TH	MESH:D004229	7054	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|nmod|END_ENTITY	However , dithiothreitol prevents and reverses these effects on TH of tetrahydrobiopterin and reactive nitrogen species .
1904772	0	dithiothreitol	10,24	carbonic_anhydrase	128,146	dithiothreitol	carbonic anhydrase	MESH:D004229	5717875(Tax:3055)	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of dithiothreitol on the catalytic activity , quaternary structure and sulfonamide-binding properties of an extracellular carbonic_anhydrase from Chlamydomonas_reinhardtii .
6280987	0	dithiothreitol	24,38	corticotropin-releasing_factor	60,90	dithiothreitol	corticotropin-releasing factor	MESH:D004229	280755(Tax:9913)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activity activity|amod|END_ENTITY	Differential effects of dithiothreitol and iodoacetamide on corticotropin-releasing_factor -LRB- CRF -RRB- activity of bovine hypothalamic CRFs and vasopressin .
986188	0	dithiothreitol	27,41	rhodanese	12,21	dithiothreitol	rhodanese	MESH:D004229	280946(Tax:9913)	Chemical	Gene	Reaction|nmod|START_ENTITY Reaction|nmod|END_ENTITY	Reaction of rhodanese with dithiothreitol .
6868151	0	dithiothreitol	15,29	thrombin	37,45	dithiothreitol	thrombin	MESH:D004229	2147	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	-LSB- The effect of dithiothreitol on the thrombin coagulating activity -RSB- .
22370944	0	dithranol	34,43	E2A	47,50	dithranol	E2A	MESH:D000875	6929	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effects of the antipsoriatic drug dithranol on E2A and caspase-9 gene expression in vitro .
18676951	0	dityrosine	73,83	Dtr1p	97,102	dityrosine	Dtr1p	CHEBI:50607	852478(Tax:4932)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Sorting signals within the Saccharomyces_cerevisiae sporulation-specific dityrosine transporter , Dtr1p , C terminus promote Golgi-to-prospore membrane transport .
6030988	0	dityrosine	13,23	elastin	27,34	dityrosine	elastin	CHEBI:50607	2006	Chemical	Gene	Evidence|nmod|START_ENTITY Evidence|nmod|END_ENTITY	Evidence for dityrosine in elastin .
9397426	0	divalproex_sodium	11,28	5-HT1A_receptor	32,47	divalproex sodium	5-HT1A receptor	MESH:D014635	3350	Chemical	Gene	START_ENTITY|nmod|function function|amod|END_ENTITY	Effects of divalproex_sodium on 5-HT1A_receptor function in healthy human males : hypothermic , hormonal , and behavioral responses to ipsapirone .
26541986	0	diverse_alkane	14,28	alkB	41,45	diverse alkane	alkB	null	8846	Chemical	Gene	genes|amod|START_ENTITY genes|compound|END_ENTITY	Occurrence of diverse_alkane hydroxylase alkB genes in indigenous oil-degrading bacteria of Baltic Sea surface water .
15695432	0	divinyl_chlorophylls	75,95	pcb2	52,56	divinyl chlorophylls	pcb2	null	831984(Tax:3702)	Chemical	Gene	START_ENTITY|nsubj|Characterization Characterization|nmod|END_ENTITY	Characterization of the Arabidopsis_thaliana mutant pcb2 which accumulates divinyl_chlorophylls .
17803859	0	dizocilpine	11,22	P-glycoprotein	26,40	dizocilpine	P-glycoprotein	MESH:D016291	287115(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effect of dizocilpine on P-glycoprotein expression in hippocampus in limbic seizure : experiment with rats -RSB- .
18390208	0	dl-3-n-butylphthalide	12,33	VEGF	51,55	dl-3-n-butylphthalide	VEGF	null	83785(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of dl-3-n-butylphthalide on expression of VEGF and bFGF in rat brain with permanent focal cerebral_ischemia -RSB- .
19626991	0	dl-3n-butylphthalide	12,32	VEGF	54,58	dl-3n-butylphthalide	VEGF	null	83785(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of dl-3n-butylphthalide on the expression of VEGF and bFGF in transient middle_cerebral_artery occlusion rats -RSB- .
26625205	0	dl922-947	20,29	CCL2	59,63	dl922-947	CCL2	null	6347	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	The oncolytic virus dl922-947 reduces IL-8 / CXCL8 and MCP-1 / CCL2 expression and impairs angiogenesis and macrophage infiltration in anaplastic thyroid_carcinoma .
16815566	0	dobutamine	69,79	adrenomedullin	7,21	dobutamine	adrenomedullin	MESH:D004280	133	Chemical	Gene	infusion|compound|START_ENTITY END_ENTITY|nmod|infusion	Plasma adrenomedullin and endothelin-1 concentration during low-dose dobutamine infusion : Relationship between pulmonary uptake and pulmonary vascular pressure/flow characteristics .
26380773	0	dobutamine	10,20	aquaporin_5	29,40	dobutamine	aquaporin 5	MESH:D004280	100008838(Tax:9986)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of dobutamine on lung aquaporin_5 in endotoxine shock-induced acute lung_injury rabbit .
23393328	0	docetaxel	16,25	ABCC4	0,5	docetaxel	ABCC4	MESH:C067311	10257	Chemical	Gene	START_ENTITY|nsubj|Decreases Decreases|compound|END_ENTITY	ABCC4 Decreases docetaxel and not cabazitaxel efficacy in prostate_cancer cells in vitro .
21862729	0	docetaxel	74,83	BRCA1	19,24	docetaxel	BRCA1	MESH:C067311	672	Chemical	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	mRNA expression of BRCA1 , PIAS1 , and PIAS4 and survival after second-line docetaxel in advanced gastric_cancer .
12140145	0	docetaxel	44,53	CPT-11	24,30	docetaxel	CPT-11	MESH:C067311	963084(Tax:115711)	Chemical	Gene	study|dep|START_ENTITY study|nmod|END_ENTITY	Phase I study of weekly CPT-11 -LRB- irinotecan -RRB- / docetaxel in patients with advanced solid tumors .
25860934	0	docetaxel	49,58	CYP1B1	30,36	docetaxel	CYP1B1	MESH:C067311	1545	Chemical	Gene	resistance|amod|START_ENTITY END_ENTITY|dobj|resistance	Loss of miR-200c up-regulates CYP1B1 and confers docetaxel resistance in renal_cell_carcinoma .
10778948	0	docetaxel	60,69	CYP3A4	41,47	docetaxel	CYP3A4	MESH:C067311	1576	Chemical	Gene	clearance|amod|START_ENTITY effect|nmod|clearance effect|nmod|activity activity|compound|END_ENTITY	The effect of an individual 's cytochrome CYP3A4 activity on docetaxel clearance .
11774254	0	docetaxel	26,35	CYP3A4	39,45	docetaxel	CYP3A4	MESH:C067311	1576	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Prediction of response to docetaxel by CYP3A4 mRNA expression in breast_cancer tissues .
15492266	0	docetaxel	102,111	CYP3A4	59,65	docetaxel	CYP3A4	MESH:C067311	1576	Chemical	Gene	effects|nmod|START_ENTITY enhanced|dobj|effects enhanced|nsubj|inhibitor inhibitor|appos|ritonavir ritonavir|dep|inhibitor inhibitor|nmod|END_ENTITY	HIV-1 protease inhibitor , ritonavir : a potent inhibitor of CYP3A4 , enhanced the anticancer effects of docetaxel in androgen-independent prostate_cancer cells in vitro and in vivo .
15657517	0	docetaxel	26,35	CYP3A4	71,77	docetaxel	CYP3A4	MESH:C067311	1576	Chemical	Gene	START_ENTITY|nmod|analysis analysis|nmod|expression expression|nummod|END_ENTITY	Prediction of response to docetaxel by immunohistochemical analysis of CYP3A4 expression in human breast_cancers .
19332043	0	docetaxel	19,28	CYP3A4	80,86	docetaxel	CYP3A4	MESH:C067311	1576	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|patients patients|nmod|CYP3A5 CYP3A5|compound|END_ENTITY	Side effects after docetaxel treatment in Taiwanese breast_cancer patients with CYP3A4 , CYP3A5 , and ABCB1 gene polymorphisms .
21468756	0	docetaxel	143,152	CYP3A4	15,21	docetaxel	CYP3A4	MESH:C067311	1576	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY single|nmod|pharmacokinetics single|nsubj|effects effects|nmod|END_ENTITY	The effects of CYP3A4 , CYP3A5 , ABCB1 , ABCC2 , ABCG2 and SLCO1B3 single nucleotide polymorphisms on the pharmacokinetics and pharmacodynamics of docetaxel in nasopharyngeal_carcinoma patients .
21533940	0	docetaxel	51,60	CYP3A4	0,6	docetaxel	CYP3A4	MESH:C067311	1576	Chemical	Gene	predict|advcl|START_ENTITY expression|xcomp|predict expression|nsubj|END_ENTITY	CYP3A4 expression to predict treatment response to docetaxel for metastasis and recurrence of primary breast_cancer .
11895918	0	docetaxel	42,51	Cyclooxygenase-2	0,16	docetaxel	Cyclooxygenase-2	MESH:C067311	5743	Chemical	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Cyclooxygenase-2 induction by paclitaxel , docetaxel , and taxane analogues in human monocytes and murine macrophages : structure-activity relationships and their implications .
21681119	0	docetaxel	63,72	Epidermal_growth_factor_receptor	0,32	docetaxel	Epidermal growth factor receptor	MESH:C067311	1956	Chemical	Gene	sensitivity|amod|START_ENTITY associated|nmod|sensitivity associated|nsubjpass|mutations mutations|compound|END_ENTITY	Epidermal_growth_factor_receptor mutations are associated with docetaxel sensitivity in lung_cancer .
24628949	0	docetaxel	29,38	FOXM1	0,5	docetaxel	FOXM1	MESH:C067311	2305	Chemical	Gene	mediates|advcl|START_ENTITY mediates|nsubj|END_ENTITY	FOXM1 mediates resistance to docetaxel in gastric_cancer via up-regulating Stathmin .
21136213	0	docetaxel	113,122	HER-2	154,159	docetaxel	HER-2	MESH:C067311	2064	Chemical	Gene	START_ENTITY|nmod|treatment treatment|nmod|END_ENTITY	A phase II randomized study comparing navelbine and capecitabine -LRB- Navcap -RRB- followed either by Navcap or by weekly docetaxel in the first-line treatment of HER-2 / neu negative metastatic breast_cancer .
17000695	0	docetaxel	70,79	Interleukin_6	0,13	docetaxel	Interleukin 6	MESH:C067311	3569	Chemical	Gene	predicts|advcl|START_ENTITY predicts|nsubj|END_ENTITY	Interleukin_6 , a nuclear factor-kappaB target , predicts resistance to docetaxel in hormone-independent_prostate_cancer and nuclear factor-kappaB inhibition by PS-1145 enhances docetaxel antitumor activity .
21197560	0	docetaxel	102,111	KRAS	135,139	docetaxel	KRAS	MESH:C067311	3845	Chemical	Gene	START_ENTITY|nmod|suppression suppression|nmod|END_ENTITY	miR-143 decreases_prostate_cancer cells proliferation and migration and enhances their sensitivity to docetaxel through suppression of KRAS .
26299922	0	docetaxel	120,129	Notch1	80,86	docetaxel	Notch1	MESH:C067311	4851	Chemical	Gene	targeting|nmod|START_ENTITY targeting|dobj|END_ENTITY	MiR-139-5p inhibits the biological function of breast_cancer cells by targeting Notch1 and mediates chemosensitivity to docetaxel .
10665657	0	docetaxel	15,24	P-glycoprotein	49,63	docetaxel	P-glycoprotein	MESH:C067311	5243	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of docetaxel -LRB- `` Taxotere '' -RRB- with human P-glycoprotein .
12008197	0	docetaxel	15,24	P-glycoprotein	44,58	docetaxel	P-glycoprotein	MESH:C067311	5243	Chemical	Gene	START_ENTITY|nmod|presence presence|nmod|END_ENTITY	Disposition of docetaxel in the presence of P-glycoprotein inhibition by intravenous administration of R101933 .
15110893	0	docetaxel	24,33	P-glycoprotein	87,101	docetaxel	P-glycoprotein	MESH:C067311	67078(Tax:10090)	Chemical	Gene	penetration|nmod|START_ENTITY penetration|nmod|inhibitors inhibitors|nmod|END_ENTITY	Improved penetration of docetaxel into the brain by co-administration of inhibitors of P-glycoprotein .
17331344	0	docetaxel	45,54	P-glycoprotein	58,72	docetaxel	P-glycoprotein	MESH:C067311	287115(Tax:10116)	Chemical	Gene	distribution|nmod|START_ENTITY distribution|appos|substrate substrate|amod|END_ENTITY	Bioavailability and tissular distribution of docetaxel , a P-glycoprotein substrate , are modified by interferon-alpha in rats .
21081657	0	docetaxel	27,36	P-glycoprotein	61,75	docetaxel	P-glycoprotein	MESH:C067311	5243	Chemical	Gene	START_ENTITY|nmod|combination combination|nmod|antagonist antagonist|amod|END_ENTITY	A pharmacodynamic study of docetaxel in combination with the P-glycoprotein antagonist tariquidar -LRB- XR9576 -RRB- in patients with lung , _ ovarian , _ and_cervical_cancer .
21421030	0	docetaxel	51,60	P-glycoprotein	117,131	docetaxel	P-glycoprotein	MESH:C067311	287115(Tax:10116)	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY alter|dobj|pharmacokinetics alter|advcl|reflecting reflecting|nmod|interactions interactions|amod|END_ENTITY	Danshen extract does not alter pharmacokinetics of docetaxel and clopidogrel , reflecting its negligible potential in P-glycoprotein - and cytochrome P4503A-mediated herb-drug interactions .
26027763	0	docetaxel	64,73	P-glycoprotein	15,29	docetaxel	P-glycoprotein	MESH:C067311	5243	Chemical	Gene	resistance|amod|START_ENTITY diagnose|dobj|resistance marker|acl|diagnose marker|nsubj|END_ENTITY	Serum exosomal P-glycoprotein is a potential marker to diagnose docetaxel resistance and select a taxoid for patients with prostate_cancer .
7945455	0	docetaxel	23,32	P-glycoprotein	61,75	docetaxel	P-glycoprotein	MESH:C067311	5243	Chemical	Gene	transport|nmod|START_ENTITY mediated|nsubj|transport mediated|nmod|END_ENTITY	Polarized transport of docetaxel and vinblastine mediated by P-glycoprotein in human intestinal epithelial cell monolayers .
21485547	0	docetaxel	59,68	PC3	88,91	docetaxel	PC3	MESH:C067311	5122	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	-LSB- Inhibitory effect of 5-aza-2 ' - deoxycytidine combined with docetaxel on prostate_cancer PC3 cells in vitro -RSB- .
16525670	0	docetaxel	34,43	S-1	17,20	docetaxel	S-1	MESH:C067311	5707	Chemical	Gene	START_ENTITY|nsubj|study study|nmod|END_ENTITY	Phase I study of S-1 and biweekly docetaxel combination chemotherapy for advanced and recurrent gastric_cancer .
18493761	0	docetaxel	33,42	S-1	64,67	docetaxel	S-1	MESH:C067311	5707	Chemical	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	Phase I dose escalation study of docetaxel with a fixed dose of S-1 in combination chemotherapy for advanced gastric_cancer .
23613401	0	docetaxel	29,38	S-1	58,61	docetaxel	S-1	MESH:C067311	5707	Chemical	Gene	Efficacy|nmod|START_ENTITY Efficacy|nmod|END_ENTITY	Efficacy and tolerability of docetaxel and cisplatin plus S-1 for advanced gastric_cancer .
21826527	0	docetaxel	32,41	S0215	5,10	docetaxel	S0215	MESH:C067311	1076651(Tax:198215)	Chemical	Gene	study|nmod|START_ENTITY END_ENTITY|dep|study	SWOG S0215 : a phase II study of docetaxel and vinorelbine plus filgrastim with weekly trastuzumab for HER2-positive , _ stage_IV_breast_cancer .
21569641	0	docetaxel	30,39	SPC-A1	140,146	docetaxel	SPC-A1	MESH:C067311	27032	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Sequence-dependent effect of docetaxel with gefitinib on the proliferation and signal protein expression of human lung_adenocarcinoma cell SPC-A1 -RSB- .
12970892	0	docetaxel	22,31	VEGF	49,53	docetaxel	VEGF	MESH:C067311	7422	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|nmod|END_ENTITY	Inhibitory effects of docetaxel on expression of VEGF , bFGF and MMPs of LS174T cell .
23645743	0	docetaxel	81,90	VEGF	31,35	docetaxel	VEGF	MESH:C067311	7422	Chemical	Gene	expression|nmod|START_ENTITY expression|nsubj|alteration alteration|nmod|END_ENTITY	Chemotherapeutic alteration of VEGF , PDGF and PDGFRa/b expression under 5-FU vs. docetaxel in HPV-transformed squamous_cell_carcinoma compared to HPV-negative HNSCC in vitro .
24061601	0	docetaxel	132,141	Vascular_endothelial_growth_factor	0,34	docetaxel	Vascular endothelial growth factor	MESH:C067311	7422	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|polymorphisms polymorphisms|amod|END_ENTITY	Vascular_endothelial_growth_factor polymorphisms and clinical outcome in patients with metastatic breast_cancer treated with weekly docetaxel .
23892568	0	docetaxel	83,92	Wee1	15,19	docetaxel	Wee1	MESH:C067311	7465	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of Wee1 in the circadian rhythm-dependent intestinal_damage induced by docetaxel .
18978565	0	docetaxel	18,27	cyclooxygenase-2	45,61	docetaxel	cyclooxygenase-2	MESH:C067311	19225(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Phase II study of docetaxel and celecoxib , a cyclooxygenase-2 inhibitor , in elderly or poor performance status -LRB- PS2 -RRB- patients with advanced non-small_cell_lung_cancer .
20818067	0	docetaxel	10,19	eIF3a	37,42	docetaxel	eIF3a	MESH:C067311	8669	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of docetaxel on expression of eIF3a in human lung_cancer A549 cell line .
22999386	0	docetaxel	93,102	epidermal_growth_factor_receptor_2	138,172	docetaxel	epidermal growth factor receptor 2	MESH:C067311	2064	Chemical	Gene	START_ENTITY|nmod|treatment treatment|nmod|END_ENTITY	An European Organisation for Research and Treatment of Cancer phase I study of lapatinib and docetaxel as neoadjuvant treatment for human epidermal_growth_factor_receptor_2 -LRB- HER2 -RRB- positive locally-advanced/inflammatory or large operable breast_cancer .
21399894	0	docetaxel	29,38	miRNA-34a	0,9	docetaxel	miRNA-34a	MESH:C067311	407040	Chemical	Gene	resistance|amod|START_ENTITY associated|nmod|resistance associated|nsubjpass|END_ENTITY	miRNA-34a is associated with docetaxel resistance in human breast_cancer cells .
11555607	0	docetaxel	127,136	p53	89,92	docetaxel	p53	MESH:C067311	7157	Chemical	Gene	therapeutics|compound|START_ENTITY combination|nmod|therapeutics transfer|nmod|combination transfer|nsubj|inhibition inhibition|nmod|growth growth|nmod|gene gene|compound|END_ENTITY	Synergistic inhibition of human lung_cancer cell growth by adenovirus-mediated wild-type p53 gene transfer in combination with docetaxel and radiation therapeutics in vitro and in vivo .
16080190	0	docetaxel	24,33	p53	53,56	docetaxel	p53	MESH:C067311	7157	Chemical	Gene	tubulin|nmod|START_ENTITY Induction|nmod|tubulin associated|nsubjpass|Induction associated|nmod|status status|compound|END_ENTITY	Induction of tubulin by docetaxel is associated with p53 status in human non small cell lung_cancer cell lines .
18472237	0	docetaxel	52,61	p53	0,3	docetaxel	p53	MESH:C067311	7157	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	p53 expression in concurrent chemoradiotherapy with docetaxel for head_and_neck_squamous_cell_carcinoma .
22996738	0	docetaxel	26,35	p53	11,14	docetaxel	p53	MESH:C067311	7157	Chemical	Gene	sensitivity|amod|START_ENTITY determines|dobj|sensitivity determines|nsubj|END_ENTITY	Functional p53 determines docetaxel sensitivity in prostate_cancer cells .
22996738	5	docetaxel	557,566	p53	625,628	docetaxel	p53	MESH:C067311	7157	Chemical	Gene	sensitivity|amod|START_ENTITY p53|nmod|sensitivity role|nmod|p53 tested|nsubjpass|role tested|nmod|END_ENTITY	The potential role of p53 in docetaxel sensitivity in prostate_cancer cells was tested by either p53 silencing using shRNA or p53 overexpression by introducing wild-type p53 .
15738531	0	docetaxel	10,19	prostate-specific_antigen	55,80	docetaxel	prostate-specific antigen	MESH:C067311	354	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	Effect of docetaxel in patients with hormone-dependent prostate-specific_antigen progression after local therapy for prostate_cancer .
16940810	0	docetaxel	132,141	prostate-specific_antigen	27,52	docetaxel	prostate-specific antigen	MESH:C067311	354	Chemical	Gene	START_ENTITY|nsubj|significance significance|nmod|phenomenon phenomenon|amod|END_ENTITY	Clinical significance of a prostate-specific_antigen flare phenomenon in patients with hormone-refractory_prostate_cancer receiving docetaxel .
18451243	0	docetaxel	53,62	prostate-specific_antigen	102,127	docetaxel	prostate-specific antigen	MESH:C067311	354	Chemical	Gene	hormone-refractory_prostate_cancer|nmod|START_ENTITY Treatment|nmod|hormone-refractory_prostate_cancer Treatment|dep|relationships relationships|nmod|END_ENTITY	Treatment of hormone-refractory_prostate_cancer with docetaxel or mitoxantrone : relationships between prostate-specific_antigen , pain , and quality of life response and survival in the TAX-327 study .
24858569	0	docetaxel	111,120	prostate-specific_antigen	42,67	docetaxel	prostate-specific antigen	MESH:C067311	354	Chemical	Gene	chemotherapy|amod|START_ENTITY progression|nmod|chemotherapy disease|acl|progression differentiates|nmod|disease differentiates|dobj|flare flare|amod|END_ENTITY	Serum alkaline_phosphatase differentiates prostate-specific_antigen flare from early disease progression after docetaxel chemotherapy in castration-resistant_prostate_cancer with bone metastasis .
25104727	0	docetaxel	65,74	testicular_nuclear_receptor_4	12,41	docetaxel	testicular nuclear receptor 4	MESH:C067311	7182	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of testicular_nuclear_receptor_4 in chemo-resistance of docetaxel in castration-resistant_prostate_cancer .
16322305	0	docetaxel	61,70	thioredoxin	5,16	docetaxel	thioredoxin	MESH:C067311	7295	Chemical	Gene	associated|xcomp|START_ENTITY associated|nsubjpass|expression expression|compound|END_ENTITY	High thioredoxin expression is associated with resistance to docetaxel in primary breast_cancer .
10948319	0	docetaxel	124,133	thymidine_phosphorylase	50,73	docetaxel	thymidine phosphorylase	MESH:C067311	1890	Chemical	Gene	Enhancement|nmod|START_ENTITY Enhancement|nmod|END_ENTITY	Enhancement of immunohistochemical reactivity for thymidine_phosphorylase in breast_carcinoma cells after administration of docetaxel as a neoadjuvant chemotherapy in advanced breast_cancer patients .
21234736	0	docosahexaenoic_Acid	14,34	cyclooxygenase-2_and_nuclear_factor_kappa-B	116,159	docosahexaenoic Acid	cyclooxygenase-2 and nuclear factor kappa-B	CHEBI:28125	19225(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|role role|nmod|END_ENTITY	The effect of docosahexaenoic_Acid on visual evoked potentials in a mouse model of Parkinson 's _ disease : the role of cyclooxygenase-2_and_nuclear_factor_kappa-B .
23029040	0	docosahexaenoic_acid	31,51	15-lipoxygenase	0,15	docosahexaenoic acid	15-lipoxygenase	CHEBI:28125	246	Chemical	Gene	metabolites|nmod|START_ENTITY metabolites|amod|END_ENTITY	15-lipoxygenase metabolites of docosahexaenoic_acid inhibit prostate_cancer cell proliferation and survival .
17052999	0	docosahexaenoic_acid	25,45	COX-2	63,68	docosahexaenoic acid	COX-2	CHEBI:28125	5743	Chemical	Gene	actions|nmod|START_ENTITY actions|nmod|END_ENTITY	Complementary actions of docosahexaenoic_acid and genistein on COX-2 , PGE2 and invasiveness in MDA-MB-231 breast_cancer cells .
23534044	0	docosahexaenoic_acid	14,34	IL-1	58,62	docosahexaenoic acid	IL-1	CHEBI:28125	3552	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|nmod|END_ENTITY	The effect of docosahexaenoic_acid -LRB- DHA -RRB- on expression of IL-1 , IL-6 , IL-8 , and TNF-a in normal and lipopolysaccharide -LRB- LPS -RRB- - stimulated macrophages .
11360128	0	docosahexaenoic_acid	35,55	Leptin	0,6	docosahexaenoic acid	Leptin	CHEBI:28125	3952	Chemical	Gene	concentrations|amod|START_ENTITY concentrations|amod|END_ENTITY	Leptin and phospholipid-esterified docosahexaenoic_acid concentrations in plasma of women : observations during pregnancy and lactation .
18036800	0	docosahexaenoic_acid	44,64	RXR	8,11	docosahexaenoic acid	RXR	CHEBI:28125	6256	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Role Role|nmod|END_ENTITY	Role of RXR in neurite outgrowth induced by docosahexaenoic_acid .
17004129	0	docosahexaenoic_acid	54,74	choline_acetyltransferase	16,41	docosahexaenoic acid	choline acetyltransferase	CHEBI:28125	12647(Tax:10090)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	The increase of choline_acetyltransferase activity by docosahexaenoic_acid in NG108-15 cells grown in serum-free medium is independent of its effect on cell growth .
15957250	0	docosahexaenoic_acid	28,48	lipoxygenase	59,71	docosahexaenoic acid	lipoxygenase	CHEBI:28125	102577714	Chemical	Gene	formed|nmod|START_ENTITY formed|nmod|END_ENTITY	Novel oxylipins formed from docosahexaenoic_acid by potato lipoxygenase -- 10 -LRB- S -RRB- - hydroxydocosahexaenoic_acid and 10,20-dihydroxydocosahexaenoic _ acid .
23288142	0	docosahexaenoic_acid	55,75	matrix_metalloproteinase-9	14,40	docosahexaenoic acid	matrix metalloproteinase-9	CHEBI:28125	4318	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Inhibition of matrix_metalloproteinase-9 expression by docosahexaenoic_acid mediated by heme_oxygenase_1 in 12-O-tetradecanoylphorbol-13-acetate-induced MCF-7 human breast_cancer cells .
12355064	0	docosahexaenoic_acid	4,24	rhodopsin	84,93	docosahexaenoic acid	rhodopsin	CHEBI:28125	24717(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|mutations mutations|compound|END_ENTITY	Low docosahexaenoic_acid levels in rod outer segments of rats with P23H and S334ter rhodopsin mutations .
11584083	0	docosahexaenoic_acid	8,28	uncoupling_protein_3	72,92	docosahexaenoic acid	uncoupling protein 3	CHEBI:28125	22229(Tax:10090)	Chemical	Gene	intake|amod|START_ENTITY enhances|nsubj|intake enhances|dobj|expression expression|nmod|gene gene|nmod|END_ENTITY	Chronic docosahexaenoic_acid intake enhances expression of the gene for uncoupling_protein_3 and affects pleiotropic mRNA levels in skeletal muscle of aged C57BL/6NJcl mice .
23698161	0	docosahexaenoic_acid	37,57	uncoupling_protein_3	61,81	docosahexaenoic acid	uncoupling protein 3	CHEBI:28125	22229(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effects of eicosapentaenoic_acid and docosahexaenoic_acid on uncoupling_protein_3 gene expression in C -LRB- 2 -RRB- C -LRB- 12 -RRB- muscle cells .
11471489	0	docosahexanoic_acid	30,49	BRCA1	54,59	docosahexanoic acid	BRCA1	null	672	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effect of omega-3_fatty_acid -LRB- docosahexanoic_acid -RRB- on BRCA1 gene expression and growth in MCF-7 cell line .
15209504	0	dodecyl_phosphocholine	63,85	apolipoprotein_C-II	40,59	dodecyl phosphocholine	apolipoprotein C-II	MESH:C028810	344	Chemical	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	The structure and interactions of human apolipoprotein_C-II in dodecyl_phosphocholine .
9254045	0	dolichyl_phosphate	64,82	IGF-1R	143,149	dolichyl phosphate	IGF-1R	MESH:C028306	3480	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Mevalonate-regulated mechanisms in cell growth control : role of dolichyl_phosphate in expression of the insulin-like_growth_factor-1_receptor -LRB- IGF-1R -RRB- in comparison to Ras prenylation and expression of c-myc .
24161469	0	dolichyl_phosphate	30,48	P-glycoprotein	75,89	dolichyl phosphate	P-glycoprotein	MESH:C028306	287115(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	In vitro and in vivo study of dolichyl_phosphate on the efflux activity of P-glycoprotein at the blood-brain barrier .
22786889	0	domain	29,35	LBD20	57,62	domain	LBD20	null	821165(Tax:3702)	Chemical	Gene	functions|compound|START_ENTITY functions|compound|END_ENTITY	The lateral organ boundaries domain transcription factor LBD20 functions in Fusarium wilt Susceptibility and jasmonate signaling in Arabidopsis .
26356245	0	domperidone	100,111	CYP3A4	130,136	domperidone	CYP3A4	MESH:D004294	1576	Chemical	Gene	interactions|nmod|START_ENTITY interactions|nmod|END_ENTITY	A physiologically based pharmacokinetic modeling approach to predict drug-drug interactions between domperidone and inhibitors of CYP3A4 .
1631251	0	domperidone	23,34	Prolactin	0,9	domperidone	Prolactin	MESH:D004294	5617	Chemical	Gene	responses|xcomp|START_ENTITY responses|nsubj|END_ENTITY	Prolactin responses to domperidone in chronic schizophrenia .
3931942	0	domperidone	36,47	Prolactin	0,9	domperidone	Prolactin	MESH:D004294	5617	Chemical	Gene	responses|nmod|START_ENTITY responses|nsubj|END_ENTITY	Prolactin and TSH responses to both domperidone and TRH in normal and hyperprolactinaemic women after dopamine synthesis blockade .
1683559	0	domperidone	21,32	dopamine_D2-receptor	57,77	domperidone	dopamine D2-receptor	MESH:D004294	1813	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Interactions between domperidone and ropinirole , a novel dopamine_D2-receptor agonist .
6733005	0	domperidone	18,29	gastrin	33,40	domperidone	gastrin	MESH:D004294	2520	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	Lack of effect of domperidone on gastrin release : evidence for a peripheral activity of the drug .
6782467	0	domperidone	14,25	gastrin	54,61	domperidone	gastrin	MESH:D004294	2520	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|levels levels|compound|END_ENTITY	-LSB- Influence of domperidone and metoclopramide on serum gastrin levels and gastric_acid secretion -LRB- author 's transl -RRB- -RSB- .
7108512	0	domperidone	10,21	growth_hormone	45,59	domperidone	growth hormone	MESH:D004294	2688	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of domperidone on apomorphine-induced growth_hormone secretion in normal men .
3540081	0	domperidone	10,21	insulin	40,47	domperidone	insulin	MESH:D004294	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|release release|nmod|END_ENTITY	Effect of domperidone on the release of insulin after intravenous glucose load in man .
16141553	0	domperidone	11,22	motilin	49,56	domperidone	motilin	MESH:D004294	4295	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of domperidone on human plasma levels of motilin , somatostatin , gastrin , adrenocorticotropic_hormone and cortisol .
14616880	0	domperidone	20,31	prolactin	68,77	domperidone	prolactin	MESH:D004294	5617	Chemical	Gene	response|acl|START_ENTITY reflects|nsubj|response reflects|dobj|activity activity|nmod|END_ENTITY	The TSH response to domperidone reflects the biological activity of prolactin in macroprolactinaemia and hyperprolactinaemia .
22478877	0	domperidone	91,102	prolactin	20,29	domperidone	prolactin	MESH:D004294	5617	Chemical	Gene	receiving|dobj|START_ENTITY cystic_fibrosis|acl:relcl|receiving END_ENTITY|nmod|cystic_fibrosis	Monitoring of serum prolactin in pediatric patients with cystic_fibrosis who are receiving domperidone .
26298751	0	domperidone	24,35	prolactin	46,55	domperidone	prolactin	MESH:D004294	280901(Tax:9913)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|concentration concentration|compound|END_ENTITY	The dopamine antagonist domperidone increases prolactin concentration and enhances milk production in dairy cows .
3569359	0	domperidone	58,69	prolactin	16,25	domperidone	prolactin	MESH:D004294	5617	Chemical	Gene	treatment|amod|START_ENTITY TSH|nmod|treatment TSH|nsubj|serum serum|amod|END_ENTITY	Increased serum prolactin but normal TSH during prolonged domperidone treatment in children .
3938732	0	domperidone	61,72	prolactin	90,99	domperidone	prolactin	MESH:D004294	5617	Chemical	Gene	prolactin|nmod|START_ENTITY prolactin|nmod|adenoma adenoma|amod|END_ENTITY	Modulation of postinhibitory increase in plasma prolactin by domperidone in patients with prolactin secreting adenoma .
6798211	0	domperidone	32,43	prolactin	62,71	domperidone	prolactin	MESH:D004294	24683(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|release release|nmod|END_ENTITY	In-vivo and in-vitro effects of domperidone on the release of prolactin and LH in male and female rats .
7119643	0	domperidone	11,22	prolactin	43,52	domperidone	prolactin	MESH:D004294	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|nmod|END_ENTITY	Effects of domperidone on the secretion of prolactin from rat anterior pituitary glands .
7428183	0	domperidone	74,85	prolactin	7,16	domperidone	prolactin	MESH:D004294	5617	Chemical	Gene	administration|nmod|START_ENTITY levels|nmod|administration levels|compound|END_ENTITY	Plasma prolactin levels after acute and subchronic oral administration of domperidone and of metoclopramide : a cross-over study in healthy volunteers .
7460861	0	domperidone	11,22	prolactin	32,41	domperidone	prolactin	MESH:D004294	5617	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|compound|END_ENTITY	Effects of domperidone on serum prolactin levels in human beings .
8116455	0	domperidone	49,60	prolactin	95,104	domperidone	prolactin	MESH:D004294	5617	Chemical	Gene	drugs|dep|START_ENTITY investigation|nmod|drugs influencing|nsubj|investigation influencing|dobj|levels levels|compound|END_ENTITY	-LSB- Clinico-pharmacological investigation of drugs -LRB- domperidone , bromocriptine -RRB- influencing human prolactin levels from pregnancy to menopause -RSB- .
23783773	0	donepezil	23,32	Abeta	42,47	donepezil	Abeta	MESH:C076946	11820(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of sub-chronic donepezil on brain Abeta and cognition in a mouse model of Alzheimer 's _ disease .
11171913	0	donepezil	10,19	acetylcholinesterase	29,49	donepezil	acetylcholinesterase	MESH:C076946	43	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Effect of donepezil on brain acetylcholinesterase activity in patients with AD measured by PET .
11256231	0	donepezil	39,48	acetylcholinesterase	88,108	donepezil	acetylcholinesterase	MESH:C076946	43	Chemical	Gene	cholinesterase|amod|START_ENTITY activities|nmod|cholinesterase Comparison|nmod|activities inhibitors|nsubj|Comparison inhibitors|nmod|END_ENTITY	Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro .
12454562	0	donepezil	20,29	acetylcholinesterase	59,79	donepezil	acetylcholinesterase	MESH:C076946	43	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activity activity|compound|END_ENTITY	Regional effects of donepezil and rivastigmine on cortical acetylcholinesterase activity in Alzheimer 's _ disease .
15716518	0	donepezil	88,97	acetylcholinesterase	33,53	donepezil	acetylcholinesterase	MESH:C076946	43	Chemical	Gene	treatment|amod|START_ENTITY END_ENTITY|nmod|treatment	Degree of inhibition of cortical acetylcholinesterase activity and cognitive effects by donepezil treatment in Alzheimer 's _ disease .
16144975	0	donepezil	85,94	acetylcholinesterase	40,60	donepezil	acetylcholinesterase	MESH:C076946	43	Chemical	Gene	neuroprotection|amod|START_ENTITY neuroprotection|acl|afforded afforded|nmod|inhibitors inhibitors|amod|END_ENTITY	Unequal neuroprotection afforded by the acetylcholinesterase inhibitors galantamine , donepezil , and rivastigmine in SH-SY5Y neuroblastoma cells : role of nicotinic receptors .
18587286	0	donepezil	25,34	acetylcholinesterase	45,65	donepezil	acetylcholinesterase	MESH:C076946	43	Chemical	Gene	increases|amod|START_ENTITY treatment|nmod|increases END_ENTITY|nsubj|treatment	Prolonged treatment with donepezil increases acetylcholinesterase expression in the central nervous system .
19935404	0	donepezil	29,38	acetylcholinesterase	52,72	donepezil	acetylcholinesterase	MESH:C076946	43	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|compound|END_ENTITY	Estimation of plasma IC50 of donepezil for cerebral acetylcholinesterase inhibition in patients with Alzheimer_disease using positron emission tomography .
22238217	0	donepezil	67,76	acetylcholinesterase	29,49	donepezil	acetylcholinesterase	MESH:C076946	43	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|Toxicity Toxicity|nmod|END_ENTITY	Toxicity and efficacy of the acetylcholinesterase -LRB- AChe -RRB- inhibitor donepezil in childhood brain_tumor survivors : a pilot study .
23273608	0	donepezil	58,67	acetylcholinesterase	95,115	donepezil	acetylcholinesterase	MESH:C076946	43	Chemical	Gene	heterodimers|nmod|START_ENTITY Design|nmod|heterodimers fragments|nsubj|Design fragments|nmod|inhibitors inhibitors|amod|END_ENTITY	Design , synthesis and evaluation of novel heterodimers of donepezil and huperzine fragments as acetylcholinesterase inhibitors .
25201490	0	donepezil	43,52	acetylcholinesterase	11,31	donepezil	acetylcholinesterase	MESH:C076946	83817(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Adding the acetylcholinesterase inhibitor , donepezil , to losartan treatment markedly improves long-term survival in rats with chronic_heart_failure .
25266713	0	donepezil	11,20	acetylcholinesterase	25,45	donepezil	acetylcholinesterase	MESH:C076946	83817(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effects of donepezil , an acetylcholinesterase inhibitor , on neurogenesis in a rat model of vascular_dementia .
15862539	0	donepezil	26,35	nicotinic_acetylcholine-receptor	39,71	donepezil	nicotinic acetylcholine-receptor	MESH:C076946	170945(Tax:10116)	Chemical	Gene	START_ENTITY|appos|activator activator|amod|END_ENTITY	Neuroprotective effect of donepezil , a nicotinic_acetylcholine-receptor activator , on cerebral_infarction in rats .
18407501	0	donepezil	42,51	nicotinic_acetylcholine-receptor	55,87	donepezil	nicotinic acetylcholine-receptor	MESH:C076946	170945(Tax:10116)	Chemical	Gene	START_ENTITY|appos|activator activator|amod|END_ENTITY	Neuroprotective and antiamnesic effect of donepezil , a nicotinic_acetylcholine-receptor activator , on rats with concussive mild traumatic_brain_injury .
14757932	0	donepezil	11,20	nicotinic_acetylcholine_receptor	38,70	donepezil	nicotinic acetylcholine receptor	MESH:C076946	170945(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY Effects|nmod|treatment Effects|nmod|levels levels|compound|END_ENTITY	Effects of donepezil treatment on rat nicotinic_acetylcholine_receptor levels in vivo and in vitro .
24639047	0	donepezil	45,54	sigma-1_receptor	15,31	donepezil	sigma-1 receptor	MESH:C076946	29336(Tax:10116)	Chemical	Gene	occupancy|nmod|START_ENTITY occupancy|amod|END_ENTITY	Dose-dependent sigma-1_receptor occupancy by donepezil in rat brain can be assessed with -LRB- 11 -RRB- C-SA4503 and microPET .
14556235	0	dopamine	21,29	5-HT1A	51,57	dopamine	5-HT1A	MESH:D004298	3350	Chemical	Gene	START_ENTITY|nmod|receptors receptors|amod|END_ENTITY	Direct activation by dopamine of recombinant human 5-HT1A receptors : comparison with human 5-HT2C and 5-HT3 receptors .
22415605	0	dopamine	60,68	5-HT1A	0,6	dopamine	5-HT1A	MESH:D004298	24473(Tax:10116)	Chemical	Gene	efflux|compound|START_ENTITY contribute|nmod|efflux contribute|nsubj|END_ENTITY	5-HT1A and 5-HT7 receptors contribute to lurasidone-induced dopamine efflux .
11850146	0	dopamine	48,56	5-HT2A	0,6	dopamine	5-HT2A	MESH:D004298	29595(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY modulate|dobj|release END_ENTITY|dep|modulate	5-HT2A and 5-HT2C / 2B receptor subtypes modulate dopamine release induced in vivo by amphetamine and morphine in both the rat nucleus accumbens and striatum .
15579162	0	dopamine	57,65	5-HT2A	0,6	dopamine	5-HT2A	MESH:D004298	15558(Tax:10090)	Chemical	Gene	response|amod|START_ENTITY mediate|dobj|response mediate|nsubj|END_ENTITY	5-HT2A and alpha1b-adrenergic_receptors entirely mediate dopamine release , locomotor response and behavioural sensitization to opiates and psychostimulants .
18597077	0	dopamine	23,31	5-HT2A	43,49	dopamine	5-HT2A	MESH:D004298	29595(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY release|nmod|END_ENTITY	Modulation of striatal dopamine release by 5-HT2A and 5-HT2C receptor antagonists : -LSB- 11C -RSB- raclopride PET studies in the rat .
7636736	0	dopamine	100,108	5-HT2A	14,20	dopamine	5-HT2A	MESH:D004298	29595(Tax:10116)	Chemical	Gene	neurons|compound|START_ENTITY inhibition|nmod|neurons reverses|dobj|inhibition reverses|nsubj|Ritanserin Ritanserin|appos|antagonist antagonist|amod|END_ENTITY	Ritanserin , a 5-HT2A / 2C antagonist , reverses direct dopamine agonist-induced inhibition of midbrain dopamine neurons .
7636736	0	dopamine	52,60	5-HT2A	14,20	dopamine	5-HT2A	MESH:D004298	29595(Tax:10116)	Chemical	Gene	inhibition|amod|START_ENTITY reverses|dobj|inhibition reverses|nsubj|Ritanserin Ritanserin|appos|antagonist antagonist|amod|END_ENTITY	Ritanserin , a 5-HT2A / 2C antagonist , reverses direct dopamine agonist-induced inhibition of midbrain dopamine neurons .
7737334	0	dopamine	65,73	5-HT2A	14,20	dopamine	5-HT2A	MESH:D004298	29595(Tax:10116)	Chemical	Gene	efflux|amod|START_ENTITY increases|dobj|efflux increases|nsubj|antagonist antagonist|nummod|END_ENTITY	The selective 5-HT2A receptor antagonist , MDL_100 ,907 , increases dopamine efflux in the prefrontal cortex of the rat .
8882450	0	dopamine	29,37	5-HT2A	68,74	dopamine	5-HT2A	MESH:D004298	3356	Chemical	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Synthesis and affinities for dopamine -LRB- D2 -RRB- and 5-hydroxytryptamine -LRB- 5-HT2A -RRB- receptors of 1 - -LRB- benzoylpropyl -RRB- -4 - -LRB- 1-oxocycloalkyl-2-ethyl -RRB- - piperazines as cyclic_butyrophenone derivatives .
9181636	0	dopamine	139,147	5-HT2A	46,52	dopamine	5-HT2A	MESH:D004298	29595(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY rats|nmod|release reverse|nmod|rats reverse|nsubj|8-OH-DPAT 8-OH-DPAT|appos|agonist agonist|appos|antagonist antagonist|nummod|END_ENTITY	8-OH-DPAT , a 5-HT1A agonist and ritanserin , a 5-HT2A / C antagonist , reverse haloperidol-induced catalepsy in rats independently of striatal dopamine release .
9689464	0	dopamine	106,114	5-HT2A	52,58	dopamine	5-HT2A	MESH:D004298	29595(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY regulation|nmod|release receptor|nmod|regulation receptor|dep|not not|nmod|receptor receptor|nummod|END_ENTITY	Crucial role of the 5-HT2C receptor , but not of the 5-HT2A receptor , in the down regulation of stimulated dopamine release produced by pressure exposure in freely moving rats .
1711914	0	dopamine	60,68	5-HT3_receptor	14,28	dopamine	5-HT3 receptor	MESH:D004298	79246(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY release|amod|END_ENTITY	Activation of 5-HT3_receptor by 1-phenylbiguanide increases dopamine release in the rat nucleus accumbens .
9151358	0	dopamine	24,32	5-HT3_receptor	0,14	dopamine	5-HT3 receptor	MESH:D004298	79246(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY release|amod|END_ENTITY	5-HT3_receptor mediated dopamine release in the nucleus accumbens during withdrawal from continuous cocaine .
1826942	0	dopamine	121,129	5-hydroxytryptamine_1A	91,113	dopamine	5-hydroxytryptamine 1A	MESH:D004298	24473(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Conditioned reinforcing effects of 8-hydroxy-2 - -LRB- di-N-propylamino -RRB- _ tetralin : involvement of 5-hydroxytryptamine_1A and D1 dopamine receptors .
1941636	0	dopamine	93,101	A10	89,92	dopamine	A10	MESH:D004298	28870	Chemical	Gene	region|compound|START_ENTITY region|compound|END_ENTITY	Sensitization to psychostimulants and stress after injection of pertussis toxin into the A10 dopamine region .
8788469	0	dopamine	22,30	A10	18,21	dopamine	A10	MESH:D004298	28870	Chemical	Gene	system|compound|START_ENTITY system|compound|END_ENTITY	Modulation of the A10 dopamine system : electrophysiological studies of the role of 5-HT3-like receptors .
11459076	0	dopamine	59,67	AADC	30,34	dopamine	AADC	MESH:D004298	24311(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Benserazide decreases central AADC activity , extracellular dopamine levels and levodopa decarboxylation in striatum of the rat .
21784415	0	dopamine	79,87	ALDH1A1	50,57	dopamine	ALDH1A1	MESH:D004298	216	Chemical	Gene	system|compound|START_ENTITY END_ENTITY|nmod|system	Functional significance of aldehyde dehydrogenase ALDH1A1 to the nigrostriatal dopamine system .
8890942	0	dopamine	32,40	AP-1	54,58	dopamine	AP-1	MESH:D004298	24516(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Synergistic effect of D1 and D2 dopamine receptors on AP-1 DNA-binding activity in the striatum and globus pallidus of the rat with a unilateral 6-OHDA lesion of the medical forebrain bundle .
12623987	0	dopamine	40,48	AT1	29,32	dopamine	AT1	MESH:D004298	24180(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|END_ENTITY	Angiotensin_II regulation of AT1 and D3 dopamine receptors in renal proximal tubule cells of SHR .
17251429	0	dopamine	41,49	Akt	14,17	dopamine	Akt	MESH:D004298	11651(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of Akt signaling by D2 and D3 dopamine receptors in vivo .
20716947	0	dopamine	44,52	Akt	26,29	dopamine	Akt	MESH:D004298	207	Chemical	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Potential redox-sensitive Akt activation by dopamine activates Bad and promotes cell death in melanocytes .
20334701	0	dopamine	41,49	Alpha-synuclein	0,15	dopamine	Alpha-synuclein	MESH:D004298	6622	Chemical	Gene	START_ENTITY|nsubj|increases increases|amod|END_ENTITY	Alpha-synuclein overexpression increases dopamine toxicity in BE2-M17 cells .
12623987	0	dopamine	40,48	Angiotensin_II	0,14	dopamine	Angiotensin II	MESH:D004298	24179(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|compound|END_ENTITY	Angiotensin_II regulation of AT1 and D3 dopamine receptors in renal proximal tubule cells of SHR .
17003572	0	dopamine	39,47	Angiotensin_II	0,14	dopamine	Angiotensin II	MESH:D004298	24179(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY regulates|dobj|uptake regulates|nsubj|END_ENTITY	Angiotensin_II regulates extraneuronal dopamine uptake in the kidney .
19293600	0	dopamine	35,43	Angiotensin_II	0,14	dopamine	Angiotensin II	MESH:D004298	24179(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY regulation|nmod|uptake regulation|compound|END_ENTITY	Angiotensin_II regulation of renal dopamine uptake and Na -LRB- + -RRB- , K -LRB- + -RRB- - ATPase activity .
20643829	0	dopamine	15,23	Argonaute_2	0,11	dopamine	Argonaute 2	MESH:D004298	239528(Tax:10090)	Chemical	Gene	neurons|amod|START_ENTITY END_ENTITY|nmod|neurons	Argonaute_2 in dopamine 2 receptor-expressing neurons regulates cocaine_addiction .
15544851	0	dopamine	43,51	Atrial_natriuretic_factor	0,25	dopamine	Atrial natriuretic factor	MESH:D004298	24602(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY stimulates|dobj|uptake stimulates|nsubj|END_ENTITY	Atrial_natriuretic_factor stimulates renal dopamine uptake mediated by natriuretic peptide-type A receptor .
1832381	0	dopamine	32,40	Atrial_natriuretic_factor	0,25	dopamine	Atrial natriuretic factor	MESH:D004298	4878	Chemical	Gene	infusion|amod|START_ENTITY END_ENTITY|nmod|infusion	Atrial_natriuretic_factor after dopamine infusion in healthy subjects and in congestive_heart_failure .
11754489	0	dopamine	9,17	BDNF	51,55	dopamine	BDNF	MESH:D004298	12064(Tax:10090)	Chemical	Gene	output|compound|START_ENTITY compromised|nsubjpass|output compromised|nmod|/ /|dep|mice mice|amod|END_ENTITY	Striatal dopamine output is compromised within + / - BDNF mice .
12644273	0	dopamine	63,71	BDNF	83,87	dopamine	BDNF	MESH:D004298	24225(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY potentiation|nmod|release involved|nmod|potentiation involved|nmod|END_ENTITY	Signalling pathways involved in the short-term potentiation of dopamine release by BDNF .
14755628	0	dopamine	41,49	BDNF	65,69	dopamine	BDNF	MESH:D004298	12064(Tax:10090)	Chemical	Gene	innervation|compound|START_ENTITY innervation|nmod|mice mice|compound|END_ENTITY	Methamphetamine-induced loss of striatal dopamine innervation in BDNF heterozygote mice does not further reduce D3 receptor concentrations .
16469931	0	dopamine	41,49	BDNF	18,22	dopamine	BDNF	MESH:D004298	12064(Tax:10090)	Chemical	Gene	pathway|compound|START_ENTITY END_ENTITY|nmod|pathway	Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress .
17971830	0	dopamine	40,48	BDNF	22,26	dopamine	BDNF	MESH:D004298	627	Chemical	Gene	macaques|amod|START_ENTITY END_ENTITY|dobj|macaques	Memantine upregulates BDNF and prevents dopamine deficits_in_SIV-infected macaques : a novel pharmacological action of memantine .
19932884	0	dopamine	83,91	BDNF	61,65	dopamine	BDNF	MESH:D004298	12064(Tax:10090)	Chemical	Gene	mice|amod|START_ENTITY level|nmod|mice END_ENTITY|dobj|level	Impaired_spatial_working_memory and decreased frontal cortex BDNF protein level in dopamine transporter knockout mice .
19948956	0	dopamine	32,40	BDNF	78,82	dopamine	BDNF	MESH:D004298	24225(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|heteromer heteromer|nmod|production production|compound|END_ENTITY	Calcium signaling cascade links dopamine D1-D2 receptor heteromer to striatal BDNF production and neuronal growth .
25693197	0	dopamine	28,36	BDNF	20,24	dopamine	BDNF	MESH:D004298	24225(Tax:10116)	Chemical	Gene	neurons|amod|START_ENTITY END_ENTITY|nmod|neurons	The transfection of BDNF to dopamine neurons potentiates the effect of dopamine_d3_receptor agonist recovering the striatal innervation , dendritic spines and motor behavior in an aged rat model of Parkinson 's _ disease .
26861892	0	dopamine	18,26	BDNF	65,69	dopamine	BDNF	MESH:D004298	12064(Tax:10090)	Chemical	Gene	depletion|compound|START_ENTITY depletion|nmod|cognitive_flexibility cognitive_flexibility|nmod|END_ENTITY	Impact of partial dopamine depletion on cognitive_flexibility in BDNF heterozygous mice .
8566202	0	dopamine	76,84	BDNF	0,4	dopamine	BDNF	MESH:D004298	24225(Tax:10116)	Chemical	Gene	neurons|compound|START_ENTITY enhances|nmod|neurons enhances|nsubj|END_ENTITY	BDNF enhances the functional reinnervation of the striatum by grafted fetal dopamine neurons .
9838177	0	dopamine	112,120	BDNF	94,98	dopamine	BDNF	MESH:D004298	24225(Tax:10116)	Chemical	Gene	survival|amod|START_ENTITY treatment|nmod|survival treatment|amod|END_ENTITY	Rat fetal ventral mesencephalon grown as solid tissue cultures : influence of culture time and BDNF treatment on dopamine neuron survival and function .
12709305	0	dopamine	43,51	Brain-derived_neurotrophic_factor	0,33	dopamine	Brain-derived neurotrophic factor	MESH:D004298	627	Chemical	Gene	expression|amod|START_ENTITY controls|dobj|expression controls|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor controls dopamine D3 receptor expression : implications for neurodevelopmental psychiatric disorders .
1454818	0	dopamine	81,89	Brain-derived_neurotrophic_factor	0,33	dopamine	Brain-derived neurotrophic factor	MESH:D004298	24225(Tax:10116)	Chemical	Gene	turnover|compound|START_ENTITY augments|dobj|turnover augments|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor augments rotational_behavior and nigrostriatal dopamine turnover in vivo .
14623353	0	dopamine	43,51	Brain-derived_neurotrophic_factor	0,33	dopamine	Brain-derived neurotrophic factor	MESH:D004298	627	Chemical	Gene	expression|amod|START_ENTITY controls|dobj|expression controls|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor controls dopamine D3 receptor expression : therapeutic implications in Parkinson 's _ disease .
1613515	0	dopamine	43,51	Brain-derived_neurotrophic_factor	0,33	dopamine	Brain-derived neurotrophic factor	MESH:D004298	627	Chemical	Gene	neurons|amod|START_ENTITY protects|dobj|neurons protects|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor protects dopamine neurons against 6-hydroxydopamine and N-methyl-4-phenylpyridinium ion toxicity : involvement of the glutathione system .
17116228	0	dopamine	65,73	Brain-derived_neurotrophic_factor	0,33	dopamine	Brain-derived neurotrophic factor	MESH:D004298	12064(Tax:10090)	Chemical	Gene	receptors|amod|START_ENTITY expression|nmod|receptors regulates|dobj|expression regulates|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor regulates the expression of D1 dopamine receptors .
19409492	0	dopamine	88,96	Brain-derived_neurotrophic_factor	0,33	dopamine	Brain-derived neurotrophic factor	MESH:D004298	24225(Tax:10116)	Chemical	Gene	neurons|amod|START_ENTITY death|nmod|neurons regulates|dobj|death regulates|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor regulates early postnatal developmental cell death of dopamine neurons of the substantia nigra in vivo .
19493166	0	dopamine	90,98	Brain-derived_neurotrophic_factor	0,33	dopamine	Brain-derived neurotrophic factor	MESH:D004298	627	Chemical	Gene	progenitors|compound|START_ENTITY stem|dobj|progenitors stem|nsubj|maturation maturation|amod|END_ENTITY	Brain-derived_neurotrophic_factor facilitates maturation of mesenchymal stem cell-derived dopamine progenitors to functional neurons .
20164338	0	dopamine	88,96	Brain-derived_neurotrophic_factor	0,33	dopamine	Brain-derived neurotrophic factor	MESH:D004298	12064(Tax:10090)	Chemical	Gene	system|compound|START_ENTITY acting|nmod|system regulates|advcl|acting regulates|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor regulates hedonic feeding by acting on the mesolimbic dopamine system .
8090745	0	dopamine	85,93	Brain-derived_neurotrophic_factor	0,33	dopamine	Brain-derived neurotrophic factor	MESH:D004298	627	Chemical	Gene	neurons|compound|START_ENTITY activity|nmod|neurons increases|dobj|activity increases|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor increases the electrical activity of pars compacta dopamine neurons in vivo .
8281451	0	dopamine	90,98	Brain-derived_neurotrophic_factor	0,33	dopamine	Brain-derived neurotrophic factor	MESH:D004298	24225(Tax:10116)	Chemical	Gene	grafts|amod|START_ENTITY survival|nmod|grafts enhances|nmod|survival enhances|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor enhances function rather than survival of intrastriatal dopamine cell-rich grafts .
9836615	0	dopamine	184,192	C-3	139,142	dopamine	C-3	MESH:D004298	718	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Synthesis and biological properties of new 2beta-alkyl - _ and_2beta-aryl-3 - -LRB- substituted_phenyl -RRB- tropane derivatives : stereochemical effect of C-3 on affinity and selectivity for neuronal dopamine and serotonin transporters .
10651109	0	dopamine	181,189	COMT	44,48	dopamine	COMT	MESH:D004298	24267(Tax:10116)	Chemical	Gene	neurons|compound|START_ENTITY evidence|nmod|neurons action|dep|evidence affect|dobj|action affect|nsubj|Inhibition Inhibition|nmod|catechol-O-methyltransferase catechol-O-methyltransferase|appos|END_ENTITY	Inhibition of catechol-O-methyltransferase -LRB- COMT -RRB- in the brain does not affect the action of dopamine and levodopa : an in vitro electrophysiological evidence from rat mesencephalic dopamine neurons .
10651109	0	dopamine	93,101	COMT	44,48	dopamine	COMT	MESH:D004298	24267(Tax:10116)	Chemical	Gene	action|nmod|START_ENTITY affect|dobj|action affect|nsubj|Inhibition Inhibition|nmod|catechol-O-methyltransferase catechol-O-methyltransferase|appos|END_ENTITY	Inhibition of catechol-O-methyltransferase -LRB- COMT -RRB- in the brain does not affect the action of dopamine and levodopa : an in vitro electrophysiological evidence from rat mesencephalic dopamine neurons .
11054777	0	dopamine	18,26	COMT	170,174	dopamine	COMT	MESH:D004298	1312	Chemical	Gene	receptor|amod|START_ENTITY forms|nmod|receptor forms|dep|interaction interaction|nmod|alleles alleles|nmod|gene gene|appos|END_ENTITY	Long forms of the dopamine receptor -LRB- DRD4 -RRB- gene VNTR are more prevalent in substance abusers : no interaction with functional alleles of the catechol-o-methyltransferase -LRB- COMT -RRB- gene .
11147513	0	dopamine	25,33	COMT	143,147	dopamine	COMT	MESH:D004298	1312	Chemical	Gene	receptors|amod|START_ENTITY stimulation|nmod|receptors stimulation|dep|implications implications|nmod|use use|nmod|inhibitors inhibitors|amod|END_ENTITY	Pulsatile stimulation of dopamine receptors and levodopa-induced motor_complications in Parkinson 's _ disease : implications for the early use of COMT inhibitors .
11318939	0	dopamine	8,16	COMT	70,74	dopamine	COMT	MESH:D004298	24267(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	D1-like dopamine receptor activation and natriuresis by nitrocatechol COMT inhibitors .
11489299	0	dopamine	119,127	COMT	90,94	dopamine	COMT	MESH:D004298	24267(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY Effect|nmod|metabolism Effect|appos|endogenous endogenous|dep|inhibitor inhibitor|appos|END_ENTITY	Effect of intracerebral 6-nitronoradrenaline , an endogenous catechol-O-methyltransferase -LRB- COMT -RRB- inhibitor , on striatal dopamine metabolism in anaesthetised rats .
1381981	0	dopamine	39,47	COMT	11,15	dopamine	COMT	MESH:D004298	24267(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY inhibitors|nmod|metabolism inhibitors|amod|END_ENTITY	Effects of COMT inhibitors on striatal dopamine metabolism : a microdialysis study .
15261699	0	dopamine	17,25	COMT	46,50	dopamine	COMT	MESH:D004298	1312	Chemical	Gene	degradation|amod|START_ENTITY Polymorphisms|nmod|degradation enzyme|nsubj|Polymorphisms enzyme|dobj|genes genes|appos|END_ENTITY	Polymorphisms of dopamine degradation enzyme -LRB- COMT and MAO -RRB- genes and tardive_dyskinesia in patients with schizophrenia .
15821730	0	dopamine	9,17	COMT	83,87	dopamine	COMT	MESH:D004298	1312	Chemical	Gene	START_ENTITY|dep|interaction interaction|nmod|genotype genotype|amod|END_ENTITY	Midbrain dopamine and prefrontal function in humans : interaction and modulation by COMT genotype .
18486967	0	dopamine	106,114	COMT	157,161	dopamine	COMT	MESH:D004298	1312	Chemical	Gene	metabolism|amod|START_ENTITY involved|nmod|metabolism genes|acl|involved variation|nmod|genes relation|nmod|variation behavior|nmod|relation study|nmod|behavior study|dep|Catechol-O-methyltransferase Catechol-O-methyltransferase|appos|END_ENTITY	A community-based study of cigarette smoking behavior in relation to variation in three genes involved in dopamine metabolism : Catechol-O-methyltransferase -LRB- COMT -RRB- , dopamine_beta-hydroxylase -LRB- DBH -RRB- and monoamine_oxidase-A -LRB- MAO-A -RRB- .
20038544	0	dopamine	56,64	COMT	15,19	dopamine	COMT	MESH:D004298	1312	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|END_ENTITY	The effects of COMT -LRB- Val108/158Met -RRB- and DRD4 -LRB- SNP -521 -RRB- dopamine genotypes on brain activations related to valence and magnitude of rewards .
20434465	0	dopamine	124,132	COMT	71,75	dopamine	COMT	MESH:D004298	1312	Chemical	Gene	role|nmod|START_ENTITY evidence|nmod|role polymorphism|dep|evidence polymorphism|appos|END_ENTITY	The flexible mind is associated with the catechol-O-methyltransferase -LRB- COMT -RRB- Val158Met polymorphism : evidence for a role of dopamine in the control of task-switching .
20626558	0	dopamine	29,37	COMT	21,25	dopamine	COMT	MESH:D004298	12846(Tax:10090)	Chemical	Gene	clearance|amod|START_ENTITY role|nmod|clearance role|nmod|END_ENTITY	Quantitative role of COMT in dopamine clearance in the prefrontal cortex of freely moving mice .
22917559	5	dopamine	1485,1493	COMT	1570,1574	dopamine	COMT	MESH:D004298	1312	Chemical	Gene	START_ENTITY|acl|mediated mediated|nmod|END_ENTITY	A two-stage enzymatic assay showed the sequential methylation and sulfation of dopamine , epinephrine , isoproterenol , and isoetharine mediated by , respectively , the COMT and the cytosolic sulfotransferase SULT1A3 .
23613951	0	dopamine	80,88	COMT	60,64	dopamine	COMT	MESH:D004298	24267(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY inhibition|nmod|metabolism inhibition|appos|END_ENTITY	Sexually dimorphic effects of catechol-O-methyltransferase -LRB- COMT -RRB- inhibition on dopamine metabolism in multiple brain regions .
23966969	0	dopamine	9,17	COMT	33,37	dopamine	COMT	MESH:D004298	1312	Chemical	Gene	Count|nmod|START_ENTITY Count|dep|influences influences|nmod|polymorphisms polymorphisms|amod|END_ENTITY	Count on dopamine : influences of COMT polymorphisms on numerical cognition .
24773408	0	dopamine	58,66	COMT	4,8	dopamine	COMT	MESH:D004298	1312	Chemical	Gene	antagonist|amod|START_ENTITY effect|nmod|antagonist regulates|dobj|effect regulates|nsubj|polymorphism polymorphism|compound|END_ENTITY	The COMT Val158Met polymorphism regulates the effect of a dopamine antagonist on the feedback-related negativity .
24902721	2	dopamine	329,337	COMT	286,290	dopamine	COMT	MESH:D004298	1312	Chemical	Gene	degrades|xcomp|START_ENTITY enzyme|acl:relcl|degrades enzyme|nsubj|catechol-O-methyltransferase catechol-O-methyltransferase|appos|END_ENTITY	The dopamine system plays a role in substance use , and catechol-O-methyltransferase -LRB- COMT -RRB- is an important enzyme that degrades dopamine .
25124664	0	dopamine	125,133	COMT	21,25	dopamine	COMT	MESH:D004298	1312	Chemical	Gene	model|compound|START_ENTITY differences|nmod|model effects|nmod|differences effects|nmod|END_ENTITY	Epistasis effects of COMT and MTHFR on inter-individual differences in mental health : under the inverted U-shaped prefrontal dopamine model .
26376054	0	dopamine	126,134	COMT	18,22	dopamine	COMT	MESH:D004298	1312	Chemical	Gene	transmission|amod|START_ENTITY influence|nmod|transmission Epistasis|dep|influence Epistasis|nmod|Val158Met Val158Met|compound|END_ENTITY	Epistasis between COMT Val158Met and DRD3 Ser9Gly polymorphisms and cognitive function in schizophrenia : genetic influence on dopamine transmission .
7389825	0	dopamine	49,57	COMT	20,24	dopamine	COMT	MESH:D004298	24267(Tax:10116)	Chemical	Gene	levels|amod|START_ENTITY activity|nmod|levels activity|amod|END_ENTITY	The significance of COMT activity in controlling dopamine agonist levels in brain and serum : studies with a prodrug and a metabolite of 6,7-ADTN .
8989196	20	dopamine	2855,2863	COMT	2796,2800	dopamine	COMT	MESH:D004298	1312	Chemical	Gene	clearance|amod|START_ENTITY correlation|nmod|clearance lack|nmod|correlation suggests|nsubj|lack suggests|advcl|observed observed|nsubj|variability variability|nmod|activity activity|amod|END_ENTITY	While concomitant variability in COMT activity is observed , the lack of correlation between dopamine clearance and COMT activity suggests that COMT is not rate-limiting for the clearance of exogenously administered dopamine .
8989196	20	dopamine	2978,2986	COMT	2796,2800	dopamine	COMT	MESH:D004298	1312	Chemical	Gene	clearance|nmod|START_ENTITY rate-limiting|nmod|clearance suggests|ccomp|rate-limiting suggests|advcl|observed observed|nsubj|variability variability|nmod|activity activity|amod|END_ENTITY	While concomitant variability in COMT activity is observed , the lack of correlation between dopamine clearance and COMT activity suggests that COMT is not rate-limiting for the clearance of exogenously administered dopamine .
19891960	0	dopamine	51,59	CRF	44,47	dopamine	CRF	MESH:D004298	1392	Chemical	Gene	neurons|amod|START_ENTITY END_ENTITY|nmod|neurons	Convergent actions of orexin/hypocretin and CRF on dopamine neurons : Emerging players in addiction .
12895416	0	dopamine	111,119	CRF_receptor_2	93,107	dopamine	CRF receptor 2	MESH:D004298	1395	Chemical	Gene	neurons|amod|START_ENTITY END_ENTITY|nmod|neurons	Corticotropin-releasing_factor requires CRF_binding_protein to potentiate NMDA receptors via CRF_receptor_2 in dopamine neurons .
12106166	0	dopamine	32,40	Cholecystokinin	0,15	dopamine	Cholecystokinin	MESH:D004298	101096837	Chemical	Gene	Corelease|nmod|START_ENTITY END_ENTITY|dep|Corelease	Cholecystokinin : Corelease with dopamine from nigrostriatal neurons in the cat .
12560135	0	dopamine	77,85	Cholecystokinin	0,15	dopamine	Cholecystokinin	MESH:D004298	25298(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY accumbens|dobj|release accumbens|nsubj|END_ENTITY	Cholecystokinin combined with serotonin in the hypothalamus limits accumbens dopamine release while increasing acetylcholine : a possible satiation mechanism .
1687681	0	dopamine	99,107	Cholecystokinin	0,15	dopamine	Cholecystokinin	MESH:D004298	25298(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY midbrain|dep|activity END_ENTITY|dep|midbrain	Cholecystokinin -LRB- CCK -RRB- and schizophrenia : the selective CCKB antagonist LY262691 decreases midbrain dopamine unit activity .
1993898	0	dopamine	41,49	Cholecystokinin	0,15	dopamine	Cholecystokinin	MESH:D004298	25298(Tax:10116)	Chemical	Gene	accumbens|amod|START_ENTITY release|nmod|accumbens modulates|dobj|release modulates|nsubj|END_ENTITY	Cholecystokinin modulates the release of dopamine from the anterior and posterior nucleus accumbens by two different mechanisms .
3037032	0	dopamine	27,35	Cholecystokinin	0,15	dopamine	Cholecystokinin	MESH:D004298	885	Chemical	Gene	synthesis|amod|START_ENTITY stimulates|dobj|synthesis stimulates|nsubj|END_ENTITY	Cholecystokinin stimulates dopamine synthesis in synaptosomes by a cyclic_AMP-dependent mechanism .
3208120	0	dopamine	86,94	Cholecystokinin	0,15	dopamine	Cholecystokinin	MESH:D004298	885	Chemical	Gene	neurons|amod|START_ENTITY reverses|nmod|neurons reverses|nsubj|lorglumide lorglumide|compound|END_ENTITY	Cholecystokinin antagonist lorglumide reverses chronic_haloperidol-induced effects on dopamine neurons .
3219572	0	dopamine	83,91	Cholecystokinin	0,15	dopamine	Cholecystokinin	MESH:D004298	12424(Tax:10090)	Chemical	Gene	release|compound|START_ENTITY increases|nmod|release attenuates|dobj|increases attenuates|nsubj|END_ENTITY	Cholecystokinin attenuates basal and drug-induced increases of limbic and striatal dopamine release .
3427413	0	dopamine	28,36	Cholecystokinin	0,15	dopamine	Cholecystokinin	MESH:D004298	25298(Tax:10116)	Chemical	Gene	inhibition|amod|START_ENTITY potentiates|dobj|inhibition potentiates|nsubj|END_ENTITY	Cholecystokinin potentiates dopamine inhibition of mesencephalic dopamine neurons in vitro .
3427413	0	dopamine	65,73	Cholecystokinin	0,15	dopamine	Cholecystokinin	MESH:D004298	25298(Tax:10116)	Chemical	Gene	neurons|compound|START_ENTITY inhibition|nmod|neurons potentiates|dobj|inhibition potentiates|nsubj|END_ENTITY	Cholecystokinin potentiates dopamine inhibition of mesencephalic dopamine neurons in vitro .
3958963	0	dopamine	61,69	Cholecystokinin	0,15	dopamine	Cholecystokinin	MESH:D004298	25298(Tax:10116)	Chemical	Gene	accumbens|amod|START_ENTITY release|nmod|accumbens alter|dobj|release alter|nsubj|octapeptides octapeptides|compound|END_ENTITY	Cholecystokinin octapeptides alter the release of endogenous dopamine from the rat nucleus accumbens in vitro .
7613631	0	dopamine	77,85	Cholecystokinin	0,15	dopamine	Cholecystokinin	MESH:D004298	25298(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY modulates|dobj|receptors modulates|nsubj|octapeptide octapeptide|compound|END_ENTITY	Cholecystokinin octapeptide in vitro and ex vivo strongly modulates striatal dopamine D2 receptors in rat forebrain sections .
8584197	0	dopamine	50,58	Cholecystokinin	0,15	dopamine	Cholecystokinin	MESH:D004298	25298(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY corrected|dobj|release corrected|nsubj|-LSB- -LSB-|compound|END_ENTITY	Cholecystokinin -LSB- corrected -RSB- octapeptide modulates dopamine release in rat striatum .
23939187	0	dopamine	75,83	Choline_transporter	0,19	dopamine	Choline transporter	MESH:D004298	63993(Tax:10090)	Chemical	Gene	levels|compound|START_ENTITY results|nmod|levels results|amod|END_ENTITY	Choline_transporter hemizygosity results in diminished basal extracellular dopamine levels in nucleus accumbens and blunts dopamine elevations following cocaine or nicotine .
8242372	0	dopamine	32,40	Chromogranin_A	0,14	dopamine	Chromogranin A	MESH:D004298	24258(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY inhibits|dobj|release inhibits|nsubj|END_ENTITY	Chromogranin_A inhibits retinal dopamine release .
9928879	0	dopamine	24,32	Chromogranin_A	0,14	dopamine	Chromogranin A	MESH:D004298	24258(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY inhibits|dobj|release inhibits|nsubj|END_ENTITY	Chromogranin_A inhibits dopamine release from rat striatal slices .
1687392	0	dopamine	29,37	D-1	17,20	dopamine	D-1	MESH:D004298	13370(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Blockade of both D-1 and D-2 dopamine receptors may induce catalepsy in mice .
2569218	0	dopamine	47,55	D-1	39,42	dopamine	D-1	MESH:D004298	25802	Chemical	Gene	interaction|compound|START_ENTITY interaction|compound|END_ENTITY	Further evidence for two directions of D-1 :D -2 dopamine receptor interaction revealed concurrently in distinct elements of typical and atypical behaviour : studies with the new enantioselective D-2 agonist LY_163502 .
2570598	0	dopamine	4,12	D-1	0,3	dopamine	D-1	MESH:D004298	25802	Chemical	Gene	administration|compound|START_ENTITY administration|compound|END_ENTITY	D-1 dopamine agonist administration reduces the threshold for convulsions produced by pilocarpine .
3094056	0	dopamine	86,94	D-1	82,85	dopamine	D-1	MESH:D004298	13370(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Bromocriptine induces marked locomotor stimulation in dopamine-depleted mice when D-1 dopamine receptors are stimulated with SKF38393 .
3261249	0	dopamine	75,83	D-1	60,63	dopamine	D-1	MESH:D004298	25802	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|treatment treatment|nmod|D-2 D-2|compound|END_ENTITY	Behavioral and biochemical effect of chronic treatment with D-1 and/or D-2 dopamine agonists in MPTP monkeys .
9292777	0	dopamine	47,55	D-1	29,32	dopamine	D-1	MESH:D004298	25802	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation and expression of D-1 , but not D-5 , dopamine receptors in human SK-N-MC neuroblastoma cells .
1533304	0	dopamine	76,84	D-1_and_D-2	0,11	dopamine	D-1 and D-2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	depleted|nmod|START_ENTITY depleted|nsubj|mediation mediation|amod|END_ENTITY	D-1_and_D-2 receptor mediation of sensorimotor behavior in rats depleted of dopamine during development .
1979179	0	dopamine	40,48	D-1_and_D-2	28,39	dopamine	D-1 and D-2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|END_ENTITY	Synergistic effects between D-1_and_D-2 dopamine antagonists on catalepsy in rats .
2037020	0	dopamine	23,31	D-1_and_D-2	11,22	dopamine	D-1 and D-2	MESH:D004298	25802;28503	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of D-1_and_D-2 dopamine antagonists on ERG and optic nerve response of the cat .
2309160	0	dopamine	99,107	D-1_and_D-2	87,98	dopamine	D-1 and D-2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	agonists|compound|START_ENTITY agonists|amod|END_ENTITY	Nigrostriatal lesion alters neurophysiological responses to selective and nonselective D-1_and_D-2 dopamine agonists in rat globus pallidus .
2949056	0	dopamine	111,119	D-1_and_D-2	120,131	dopamine	D-1 and D-2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|affinities affinities|compound|END_ENTITY	Inhibition of SKF_38393 - and pergolide-induced circling in rats with unilateral 6-OHDA lesion is correlated to dopamine D-1_and_D-2 receptor affinities in vitro .
3878300	0	dopamine	113,121	D-1_and_D-2	122,133	dopamine	D-1 and D-2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	SKF_38393 and apomorphine modify locomotion and exploration in rats placed on a holeboard by separate actions at dopamine D-1_and_D-2 receptors .
7566505	0	dopamine	65,73	D-1_and_D-2	53,64	dopamine	D-1 and D-2	MESH:D004298	28503	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|SCH_32615 SCH_32615|nmod|END_ENTITY	Effects of SCH_32615 , an enkephalinase inhibitor , on D-1_and_D-2 dopamine receptor-mediated behaviors .
10473190	0	dopamine	40,48	D-2	49,52	dopamine	D-2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	START_ENTITY|xcomp|using using|nsubj|receptor receptor|compound|END_ENTITY	Preliminary assessment of extrastriatal dopamine D-2 receptor binding in the rodent and nonhuman primate brains using the high affinity radioligand , 18F-fallypride .
1674541	0	dopamine	82,90	D-2	91,94	dopamine	D-2	MESH:D004298	28503	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Conformational properties of semirigid antipsychotic drugs : the pharmacophore for dopamine D-2 antagonist activity .
1982893	0	dopamine	42,50	D-2	11,14	dopamine	D-2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY agonists|nmod|release agonists|compound|END_ENTITY	Effects of D-2 agonists on the release of dopamine : localization of the mechanism of action .
2151400	0	dopamine	16,24	D-2	0,3	dopamine	D-2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	agonists|compound|START_ENTITY agonists|amod|END_ENTITY	D-2 but not D-1 dopamine agonists produce augmented behavioral response in rats after subchronic treatment with methamphetamine or cocaine .
2251338	0	dopamine	33,41	D-2	29,32	dopamine	D-2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of chronic D-1 and/or D-2 dopamine antagonist treatment on SKF_38393-induced non-stereotyped grooming .
2527290	0	dopamine	61,69	D-2	11,14	dopamine	D-2	MESH:D004298	28503	Chemical	Gene	overflow|amod|START_ENTITY stimulated|dobj|overflow stimulated|nsubj|Effects Effects|nmod|antagonists antagonists|compound|END_ENTITY	Effects of D-2 antagonists on frequency-dependent stimulated dopamine overflow in nucleus accumbens and caudate-putamen .
2565817	0	dopamine	88,96	D-2	84,87	dopamine	D-2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	agonist|compound|START_ENTITY agonist|compound|END_ENTITY	Biochemical and functional studies on EMD 49,980 : a potent , selectively presynaptic D-2 dopamine agonist with actions on serotonin systems .
2569218	0	dopamine	47,55	D-2	193,196	dopamine	D-2	MESH:D004298	28503	Chemical	Gene	interaction|compound|START_ENTITY directions|nmod|interaction evidence|nmod|directions revealed|nsubj|evidence revealed|nmod|elements elements|nmod|behaviour behaviour|dep|studies studies|nmod|LY_163502 LY_163502|compound|END_ENTITY	Further evidence for two directions of D-1 :D -2 dopamine receptor interaction revealed concurrently in distinct elements of typical and atypical behaviour : studies with the new enantioselective D-2 agonist LY_163502 .
2571717	0	dopamine	75,83	D-2	89,92	dopamine	D-2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	values|amod|START_ENTITY values|compound|END_ENTITY	Classification of typical and atypical antipsychotic_drugs on the basis of dopamine D-1 , D-2 and serotonin2 pKi values .
2864260	0	dopamine	30,38	D-2	26,29	dopamine	D-2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	agonist|compound|START_ENTITY agonist|compound|END_ENTITY	SCH-23390 antagonism of a D-2 dopamine agonist depends upon catecholaminergic neurons .
2875894	0	dopamine	20,28	D-2	106,109	dopamine	D-2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	blockers|amod|START_ENTITY effect|nmod|blockers effect|dep|END_ENTITY	Enhancing effect of dopamine blockers on evoked acetylcholine release in rat striatal slices : a classical D-2 antagonist response ?
2935411	0	dopamine	57,65	D-2	53,56	dopamine	D-2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|characterisation characterisation|nmod|END_ENTITY	Localisation and pharmacological characterisation of D-2 dopamine receptors in rat cerebral neocortex and cerebellum using -LSB- 125I -RSB- iodosulpride .
2950291	0	dopamine	64,72	D-2	0,3	dopamine	D-2	MESH:D004298	28503	Chemical	Gene	neurons|compound|START_ENTITY dopamine|nmod|neurons dopamine|nsubj|END_ENTITY	D-2 dopamine antagonist-like effects of SCH_23390 on A9 and A10 dopamine neurons .
2951613	0	dopamine	92,100	D-2	0,3	dopamine	D-2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	fibers|amod|START_ENTITY showing|dobj|fibers regions|acl|showing regulate|nmod|regions regulate|nsubj|dopamine-receptors dopamine-receptors|compound|END_ENTITY	D-2 dopamine-receptors regulate the release of -LSB- 3H -RSB- dopamine in rat cortical regions showing dopamine immunoreactive fibers .
2957221	0	dopamine	62,70	D-2	46,49	dopamine	D-2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|evidence evidence|nmod|functionality functionality|nmod|END_ENTITY	Behavioural evidence for the functionality of D-2 but not D-1 dopamine receptors at multiple brain sites in the 6-hydroxydopamine-lesioned rat .
3130270	0	dopamine	24,32	D-2	20,23	dopamine	D-2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	agonist|amod|START_ENTITY agonist|amod|END_ENTITY	N-0437 : a selective D-2 dopamine receptor agonist in in vitro and in vivo models .
3161508	0	dopamine	30,38	D-2	26,29	dopamine	D-2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	labeling|dep|START_ENTITY labeling|nmod|END_ENTITY	Photoaffinity labeling of D-2 dopamine binding subunits from rat striatum , anterior pituitary and olfactory bulb with a new probe , -LSB- 3H -RSB- azidosulpride .
3261249	0	dopamine	75,83	D-2	71,74	dopamine	D-2	MESH:D004298	28503	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|treatment treatment|nmod|END_ENTITY	Behavioral and biochemical effect of chronic treatment with D-1 and/or D-2 dopamine agonists in MPTP monkeys .
6149143	0	dopamine	21,29	D-2	69,72	dopamine	D-2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY Loss|nmod|receptors selective|nsubj|Loss selective|nmod|sites sites|amod|END_ENTITY	Loss of rat striatal dopamine receptors with ageing is selective for D-2 but not D-1 sites : association with increased non-specific binding of the D-1 ligand -LSB- 3H -RSB- piflutixol .
6241567	0	dopamine	112,120	D-2	152,155	dopamine	D-2	MESH:D004298	28503	Chemical	Gene	receptor|compound|START_ENTITY antagonists|nmod|receptor Identification|nmod|antagonists Identification|dep|comparisons comparisons|nmod|enantioselectivity enantioselectivity|compound|END_ENTITY	Identification of the enantiomers of SK_F 83566 as specific and stereoselective antagonists at the striatal D-1 dopamine receptor : comparisons with the D-2 enantioselectivity of Ro_22-1319 .
7915514	0	dopamine	11,19	D-2	20,23	dopamine	D-2	MESH:D004298	28503	Chemical	Gene	START_ENTITY|dobj|agonists agonists|compound|END_ENTITY	-LSB- Selective dopamine D-2 autoreceptor agonists with 8-azaindole substructure : synthesis and theoretical studies -RSB- .
15569306	0	dopamine	3,11	D1	0,2	dopamine	D1	MESH:D004298	25802	Chemical	Gene	receptor|amod|START_ENTITY receptor|nummod|END_ENTITY	D1 dopamine receptor signaling involves caveolin-2 in HEK-293 cells .
14659580	0	dopamine	55,63	D1/D2	64,69	dopamine	D1/D2	MESH:D004298	25802	Chemical	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	Further evidence for the mediation of both subtypes of dopamine D1/D2 receptors and cerebral neuropeptide_Y -LRB- NPY -RRB- in amphetamine-induced appetite suppression .
15983794	0	dopamine	56,64	D1/D2	9,14	dopamine	D1/D2	MESH:D004298	25802	Chemical	Gene	impairs|amod|START_ENTITY conditions|nmod|impairs stimulation|nmod|conditions stimulation|compound|END_ENTITY	Combined D1/D2 receptor stimulation under conditions of dopamine depletion impairs spatial working memory performance in humans .
1822319	0	dopamine	27,35	D1/D2	36,41	dopamine	D1/D2	MESH:D004298	25802;1646	Chemical	Gene	antagonist|amod|START_ENTITY antagonist|compound|END_ENTITY	Zuclopenthixol , a combined dopamine D1/D2 antagonist , versus haloperidol , a dopamine D2 antagonist , in tardive_dyskinesia .
18313303	0	dopamine	64,72	D1/D2	73,78	dopamine	D1/D2	MESH:D004298	25802;1646	Chemical	Gene	agonist|amod|START_ENTITY agonist|compound|END_ENTITY	A novel synthesis and pharmacological evaluation of a potential dopamine D1/D2 agonist : 1-propyl-1 ,2,3,4,4 a,5,10,10a-octahydrobenzo -LSB- g -RSB- quinoline-6 ,7 - diol .
24425798	0	dopamine	68,76	D1/D2	77,82	dopamine	D1/D2	MESH:D004298	25802	Chemical	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	Stimulant side effects : prefrontal/basal ganglia circuit control at dopamine D1/D2 receptors .
10591286	0	dopamine	223,231	D1/D5	63,68	dopamine	D1/D5	MESH:D004298	25802;51366	Chemical	Gene	function|compound|START_ENTITY enhancement|nmod|function associated|nmod|enhancement BACKGROUND|parataxis|associated BACKGROUND|nsubj|Attenuation Attenuation|nmod|effects effects|nmod|cocaine cocaine|nmod|ecopipam ecopipam|amod|dopamine dopamine|dep|END_ENTITY	Attenuation of the euphoric effects of cocaine by the dopamine D1/D5 antagonist ecopipam -LRB- SCH_39166 -RRB- BACKGROUND : The subjective and reinforcing effects of cocaine in humans are associated with the enhancement of endogenous dopamine function in the mesolimbic system .
10859139	0	dopamine	80,88	D1/D5	74,79	dopamine	D1/D5	MESH:D004298	117060(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|nummod|END_ENTITY	Depotentiation in the dentate gyrus of freely moving rats is modulated by D1/D5 dopamine receptors .
17293055	0	dopamine	94,102	D1/D5	88,93	dopamine	D1/D5	MESH:D004298	117060(Tax:10116)	Chemical	Gene	activation|amod|START_ENTITY activation|nummod|END_ENTITY	Prefrontal cortical network activity : Opposite effects of psychedelic hallucinogens and D1/D5 dopamine receptor activation .
22266268	0	dopamine	6,14	D1/D5	0,5	dopamine	D1/D5	MESH:D004298	25802;51366	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	D1/D5 dopamine receptors modulate spatial memory formation .
8922403	0	dopamine	6,14	D1/D5	0,5	dopamine	D1/D5	MESH:D004298	25802	Chemical	Gene	activation|amod|START_ENTITY activation|nummod|END_ENTITY	D1/D5 dopamine receptor activation increases the magnitude of early long-term potentiation at CA1 hippocampal synapses .
8876240	0	dopamine	27,35	D1A	23,26	dopamine	D1A	MESH:D004298	24316(Tax:10116)	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Regulation of striatal D1A dopamine receptor gene transcription by Brn-4 .
10082221	0	dopamine	21,29	D1_and_D2	11,20	dopamine	D1 and D2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of D1_and_D2 dopamine receptor antagonists on cocaine-induced self-stimulation and locomotor activity in rats .
10210518	0	dopamine	42,50	D1_and_D2	32,41	dopamine	D1 and D2	MESH:D004298	13370(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|involvement involvement|nmod|END_ENTITY	Strain-dependent involvement of D1_and_D2 dopamine receptors in muscarinic cholinergic influences on memory storage .
10234040	0	dopamine	17,25	D1_and_D2	26,35	dopamine	D1 and D2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Opposing role of dopamine D1_and_D2 receptors in modulation of rat nucleus accumbens noradrenaline release .
10454529	0	dopamine	100,108	D1_and_D2	90,99	dopamine	D1 and D2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Multisecond oscillations in firing rate in the globus pallidus : synergistic modulation by D1_and_D2 dopamine receptors .
11111836	0	dopamine	30,38	D1_and_D2	73,82	dopamine	D1 and D2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY release|nsubj|Effect release|nmod|slices slices|amod|binding binding|nmod|receptors receptors|amod|END_ENTITY	Effect of amphetamine-induced dopamine release on radiotracer binding to D1_and_D2 receptors in rat brain striatal slices .
11509198	0	dopamine	26,34	D1_and_D2	35,44	dopamine	D1 and D2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Iron_deficiency decreases dopamine D1_and_D2 receptors in rat brain .
11861790	0	dopamine	71,79	D1_and_D2	61,70	dopamine	D1 and D2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|stimulation stimulation|nmod|END_ENTITY	Effects of individual and concurrent stimulation of striatal D1_and_D2 dopamine receptors on electrophysiological and behavioral output from rat basal ganglia .
1388275	0	dopamine	86,94	D1_and_D2	76,85	dopamine	D1 and D2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Reinforced responding of the 11-day-old rat pup : synergistic interaction of D1_and_D2 dopamine receptors .
1409772	0	dopamine	21,29	D1_and_D2	11,20	dopamine	D1 and D2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|amod|END_ENTITY	Effects of D1_and_D2 dopamine antagonists on behavior of polydipsic rats .
1663039	0	dopamine	95,103	D1_and_D2	104,113	dopamine	D1 and D2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|agonists agonists|amod|END_ENTITY	The kappa-opioid receptor agonist spiradoline differentially alters the rotational response to dopamine D1_and_D2 agonists .
1683341	0	dopamine	25,33	D1_and_D2	15,24	dopamine	D1 and D2	MESH:D004298	13370(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Stimulation of D1_and_D2 dopamine receptors produces additive anorectic effects .
16835769	0	dopamine	34,42	D1_and_D2	24,33	dopamine	D1 and D2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Differential ability of D1_and_D2 dopamine receptor agonists to induce and modulate expression and reinstatement of cocaine place preference in rats .
1686482	0	dopamine	62,70	D1_and_D2	11,20	dopamine	D1 and D2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	increase|nmod|START_ENTITY antagonists|nmod|increase antagonists|amod|END_ENTITY	Effects of D1_and_D2 antagonists on the transient increase of dopamine release by dopamine agonists by means of brain dialysis .
1686482	0	dopamine	82,90	D1_and_D2	11,20	dopamine	D1 and D2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	agonists|amod|START_ENTITY release|nmod|agonists release|nsubj|Effects Effects|nmod|antagonists antagonists|amod|END_ENTITY	Effects of D1_and_D2 antagonists on the transient increase of dopamine release by dopamine agonists by means of brain dialysis .
16869283	0	dopamine	30,38	D1_and_D2	39,48	dopamine	D1 and D2	MESH:D004298	13370(Tax:10090)	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	-LSB- Differential contribution of dopamine D1_and_D2 receptors in the mu-opioidergic immunomodulation -RSB- .
16914290	0	dopamine	58,66	D1_and_D2	48,57	dopamine	D1 and D2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Differential perikaryal localization in rats of D1_and_D2 dopamine receptors on striatal projection neuron types identified by retrograde labeling .
17982577	0	dopamine	8,16	D1_and_D2	70,79	dopamine	D1 and D2	MESH:D004298	25802	Chemical	Gene	receptor|compound|START_ENTITY receptor|dep|heterooligomers heterooligomers|nmod|receptors receptors|amod|END_ENTITY	A novel dopamine receptor signaling unit in brain : heterooligomers of D1_and_D2 dopamine receptors .
17982577	0	dopamine	80,88	D1_and_D2	70,79	dopamine	D1 and D2	MESH:D004298	25802	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	A novel dopamine receptor signaling unit in brain : heterooligomers of D1_and_D2 dopamine receptors .
1826460	0	dopamine	10,18	D1_and_D2	19,28	dopamine	D1 and D2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	agonists|amod|START_ENTITY agonists|amod|END_ENTITY	Selective dopamine D1_and_D2 agonists independently affect different components of the free-running circadian rhythm of locomotor activity in rats .
1830547	0	dopamine	22,30	D1_and_D2	41,50	dopamine	D1 and D2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY effects|nmod|receptors END_ENTITY|nsubj|effects	-LSB- Different effects on dopamine receptors D1_and_D2 following long-term usage of L-dopa -RSB- .
18339434	0	dopamine	8,16	D1_and_D2	17,26	dopamine	D1 and D2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Role of dopamine D1_and_D2 receptors in the nucleus accumbens shell on the acquisition and expression of fructose-conditioned flavor-flavor preferences in rats .
1890625	0	dopamine	32,40	D1_and_D2	22,31	dopamine	D1 and D2	MESH:D004298	25802	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|END_ENTITY	Behavioral effects of D1_and_D2 dopamine receptor antagonists in squirrel monkeys .
19573566	0	dopamine	17,25	D1_and_D2	26,35	dopamine	D1 and D2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|receptors receptors|amod|END_ENTITY	Role of amygdala dopamine D1_and_D2 receptors in the acquisition and expression of fructose-conditioned flavor preferences in rats .
1981169	0	dopamine	77,85	D1_and_D2	86,95	dopamine	D1 and D2	MESH:D004298	25802;28503	Chemical	Gene	agonists|amod|START_ENTITY agonists|amod|END_ENTITY	Effects of pertussis toxin on caudate neuron electrophysiology : studies with dopamine D1_and_D2 agonists .
2124337	0	dopamine	87,95	D1_and_D2	0,9	dopamine	D1 and D2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	depletions|amod|START_ENTITY altered|nmod|depletions altered|nsubjpass|contributions contributions|amod|END_ENTITY	D1_and_D2 receptor contributions to ingestive and locomotor_behavior are altered after dopamine depletions in neonatal rats .
2215930	0	dopamine	82,90	D1_and_D2	91,100	dopamine	D1 and D2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Quantitative autoradiographical analysis of the age-related modulation of central dopamine D1_and_D2 receptors .
2479025	0	dopamine	60,68	D1_and_D2	50,59	dopamine	D1 and D2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|visualization visualization|nmod|END_ENTITY	Direct visualization and cellular localization of D1_and_D2 dopamine receptors in rat forebrain by use of fluorescent ligands .
2525062	0	dopamine	18,26	D1_and_D2	8,17	dopamine	D1 and D2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Role of D1_and_D2 dopamine receptors in mediating locomotor activity elicited from the nucleus accumbens of rats .
2526946	0	dopamine	26,34	D1_and_D2	119,128	dopamine	D1 and D2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY inactivation|nmod|receptors inactivation|dep|evidence evidence|dep|expressed expressed|nsubjpass|effect effect|nmod|agonists agonists|amod|END_ENTITY	Selective inactivation of dopamine D1_and_D2 receptors in 6-hydroxydopamine-lesioned rats : evidence that the effect of D1_and_D2 agonists can be expressed in the absence of the heterologous DA receptor .
2526946	0	dopamine	26,34	D1_and_D2	35,44	dopamine	D1 and D2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Selective inactivation of dopamine D1_and_D2 receptors in 6-hydroxydopamine-lesioned rats : evidence that the effect of D1_and_D2 agonists can be expressed in the absence of the heterologous DA receptor .
2528080	0	dopamine	50,58	D1_and_D2	59,68	dopamine	D1 and D2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Anatomical and affinity state comparisons between dopamine D1_and_D2 receptors in the rat central nervous system .
2533695	0	dopamine	69,77	D1_and_D2	78,87	dopamine	D1 and D2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|receptors receptors|amod|END_ENTITY	Ovariectomy and subchronic estradiol-17 beta administration decrease dopamine D1_and_D2 receptors in rat striatum .
2891082	0	dopamine	47,55	D1_and_D2	37,46	dopamine	D1 and D2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Methamphetamine-induced reduction in D1_and_D2 dopamine receptors as evidenced by autoradiography : comparison with tyrosine hydroxylase activity .
2902647	0	dopamine	62,70	D1_and_D2	52,61	dopamine	D1 and D2	MESH:D004298	13370(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|protection protection|nmod|inhibition inhibition|nmod|EEDQ EEDQ|nmod|END_ENTITY	Selective protection from the inhibition by EEDQ of D1_and_D2 dopamine agonist-induced rotational behavior in mice .
3114439	0	dopamine	20,28	D1_and_D2	10,19	dopamine	D1 and D2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	agonists|compound|START_ENTITY agonists|amod|END_ENTITY	Selective D1_and_D2 dopamine agonists differentially alter basal ganglia glucose utilization in rats with unilateral 6-hydroxydopamine substantia nigra lesions .
3517688	0	dopamine	55,63	D1_and_D2	45,54	dopamine	D1 and D2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|amod|END_ENTITY	Electrophysiological study of the effects of D1_and_D2 dopamine antagonists on the interaction of converging inputs from the sensory-motor cortex and substantia nigra neurons in the rat .
3534157	0	dopamine	72,80	D1_and_D2	50,59	dopamine	D1 and D2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY subtypes|nmod|receptors subtypes|amod|END_ENTITY	Quantitative autoradiographic localization of the D1_and_D2 subtypes of dopamine receptors in rat brain .
6622515	0	dopamine	77,85	D1_and_D2	67,76	dopamine	D1 and D2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Differential affinity of dopaminergic agonists and antagonists for D1_and_D2 dopamine receptors in rat striatum .
7623147	0	dopamine	43,51	D1_and_D2	33,42	dopamine	D1 and D2	MESH:D004298	25802	Chemical	Gene	START_ENTITY|nsubj|analysis analysis|nmod|END_ENTITY	Electron microscopic analysis of D1_and_D2 dopamine receptor proteins in the dorsal striatum and their synaptic relationships with motor corticostriatal afferents .
7636023	0	dopamine	10,18	D1_and_D2	124,133	dopamine	D1 and D2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	START_ENTITY|parataxis|demonstrate demonstrate|dobj|segregation segregation|nmod|mRNAs mRNAs|amod|END_ENTITY	D1_and_D2 dopamine receptor gene expression in the rat striatum : sensitive cRNA probes demonstrate prominent segregation of D1_and_D2 mRNAs in distinct neuronal populations of the dorsal and ventral striatum .
7725240	0	dopamine	27,35	D1_and_D2	36,45	dopamine	D1 and D2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Cellular colocalization of dopamine D1_and_D2 receptors in rat medial prefrontal cortex .
7845612	0	dopamine	31,39	D1_and_D2	21,30	dopamine	D1 and D2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Rapid development of D1_and_D2 dopamine receptor supersensitivity as indicated by striatal and pallidal Fos expression .
7911508	0	dopamine	24,32	D1_and_D2	14,23	dopamine	D1 and D2	MESH:D004298	25802	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Activation of D1_and_D2 dopamine receptors inhibits protein_kinase_C activity in striatal synaptoneurosomes .
7974202	0	dopamine	68,76	D1_and_D2	77,86	dopamine	D1 and D2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Dopamine displays an identical apparent affinity towards functional dopamine D1_and_D2 receptors in rat striatal slices : possible implications for the regulatory role of D2 receptors .
8095545	0	dopamine	90,98	D1_and_D2	99,108	dopamine	D1 and D2	MESH:D004298	25802	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	cis-1 ,2,3 a,4,5,9b-hexahydro-3H-benz -LSB- e -RSB- indoles : synthesis and in vitro binding affinity at dopamine D1_and_D2 receptors .
8097026	0	dopamine	30,38	D1_and_D2	39,48	dopamine	D1 and D2	MESH:D004298	25802	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Heterogeneous distribution of dopamine D1_and_D2 receptors in the human ventral striatum .
8415621	0	dopamine	26,34	D1_and_D2	16,25	dopamine	D1 and D2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Localization Localization|nmod|END_ENTITY	Localization of D1_and_D2 dopamine receptors in brain with subtype-specific antibodies .
8548312	0	dopamine	57,65	D1_and_D2	47,56	dopamine	D1 and D2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	rotational_behavior|amod|START_ENTITY rotational_behavior|amod|END_ENTITY	MK-801 reverses effects of chronic levodopa on D1_and_D2 dopamine agonist-induced rotational_behavior .
8587913	0	dopamine	25,33	D1_and_D2	15,24	dopamine	D1 and D2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of D1_and_D2 dopamine systems in the behavioral effects of cocaine in rats .
8711069	0	dopamine	106,114	D1_and_D2	66,75	dopamine	D1 and D2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	depleted|nmod|START_ENTITY depleted|nsubj|mediation mediation|nmod|behavior behavior|nmod|receptors receptors|amod|END_ENTITY	Independent mediation of unconditioned motor behavior by striatal D1_and_D2 receptors in rats depleted of dopamine as neonates .
9295170	0	dopamine	31,39	D1_and_D2	21,30	dopamine	D1 and D2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	agonists|compound|START_ENTITY agonists|amod|END_ENTITY	Interactions between D1_and_D2 dopamine receptor family agonists and antagonists : the effects of chronic exposure on behavior and receptor binding in rats and their clinical implications .
9296569	0	dopamine	55,63	D1_and_D2	45,54	dopamine	D1 and D2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|aging aging|nmod|vulnerability vulnerability|nmod|END_ENTITY	Effect of aging on vulnerability of striatal D1_and_D2 dopamine receptor-containing neurons to kainic_acid .
9832956	0	dopamine	81,89	D1_and_D2	71,80	dopamine	D1 and D2	MESH:D004298	13370(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	The effects of anandamide on memory consolidation in mice involve both D1_and_D2 dopamine receptors .
17984145	0	dopamine	28,36	D1_and_D2_receptor	37,55	dopamine	D1 and D2 receptor	MESH:D004298	13488;13489	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Aluminum exposure decreases dopamine D1_and_D2_receptor expression in mouse brain .
17105899	0	dopamine	86,94	D1_and_D3	95,104	dopamine	D1 and D3	MESH:D004298	1735	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Opposite regulation of cocaine-induced intracellular signaling and gene expression by dopamine D1_and_D3 receptors .
17068774	0	dopamine	91,99	D1_or_D3_receptor	100,117	dopamine	D1 or D3 receptor	MESH:D004298	13488(Tax:10090)	Chemical	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Effects of acute `` binge '' cocaine on mRNA levels of mu_opioid_receptor and neuropeptides in dopamine D1_or_D3_receptor knockout mice .
1402930	0	dopamine	69,77	D1_receptor	78,89	dopamine	D1 receptor	MESH:D004298	13488(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|gene gene|amod|END_ENTITY	Characterization of gene organization and promoter region of the rat dopamine D1_receptor gene .
17576511	0	dopamine	20,28	D1a	16,19	dopamine	D1a	MESH:D004298	24316(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Localization of D1a dopamine receptors on cell bodies and axonal endings in the substantia nigra pars reticulata of the rat .
10580800	0	dopamine	111,119	D1b	107,110	dopamine	D1b	MESH:D004298	25195(Tax:10116)	Chemical	Gene	subtypes|compound|START_ENTITY subtypes|compound|END_ENTITY	Immunoblot and immunohistochemical comparison of murine monoclonal antibodies specific for the rat D1a and D1b dopamine receptor subtypes .
11923462	0	dopamine	8,16	D2-like	17,24	dopamine	D2-like	MESH:D004298	673094(Tax:10090)	Chemical	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	Role of dopamine D2-like receptors in cocaine self-administration : studies with D2_receptor mutant mice and novel D2_receptor antagonists .
9570028	0	dopamine	29,37	D2R	38,41	dopamine	D2R	MESH:D004298	1813	Chemical	Gene	receptors|amod|START_ENTITY receptors|nummod|END_ENTITY	A developmental study of the dopamine D2R receptors in the human basal ganglia and thalamus .
7562534	0	dopamine	36,44	D2_and_D3	26,35	dopamine	D2 and D3	MESH:D004298	29484(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	-LSB- 3H -RSB- - quinelorane binds to D2_and_D3 dopamine receptors in the rat brain .
10226933	0	dopamine	162,170	D2_receptor	202,213	dopamine	D2 receptor	MESH:D004298	13489(Tax:10090)	Chemical	Gene	competition|nmod|START_ENTITY factors|nmod|competition responsible|nsubj|factors responsible|nmod|changes changes|nmod|END_ENTITY	Enhancement of 3H-N-methylspiperone binding but not 3H-raclopride binding in mouse striatum by MK-801 : evidence that factors other than competition by endogenous dopamine are responsible for changes in D2_receptor binding in vivo .
11923462	0	dopamine	8,16	D2_receptor	80,91	dopamine	D2 receptor	MESH:D004298	13489(Tax:10090)	Chemical	Gene	receptors|amod|START_ENTITY Role|nmod|receptors Role|dep|studies studies|nmod|mice mice|amod|END_ENTITY	Role of dopamine D2-like receptors in cocaine self-administration : studies with D2_receptor mutant mice and novel D2_receptor antagonists .
18363855	0	dopamine	8,16	D2_receptor	77,88	dopamine	D2 receptor	MESH:D004298	13489(Tax:10090)	Chemical	Gene	receptors|amod|START_ENTITY Role|nmod|receptors Role|nmod|mice mice|amod|END_ENTITY	Role of dopamine D1-like receptors in methamphetamine locomotor responses of D2_receptor knockout mice .
18462709	0	dopamine	43,51	D2_receptor	8,19	dopamine	D2 receptor	MESH:D004298	13489(Tax:10090)	Chemical	Gene	synthesis|amod|START_ENTITY regulation|nmod|synthesis mediated|dobj|regulation mediated|nsubj|Lack Lack|nmod|END_ENTITY	Lack of D2_receptor mediated regulation of dopamine synthesis in A11 diencephalospinal neurons in male and female mice .
22639229	0	dopamine	91,99	D2_receptor	18,29	dopamine	D2 receptor	MESH:D004298	13489(Tax:10090)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Comparison of the D2_receptor regulation and neurotoxicant susceptibility of nigrostriatal dopamine neurons in wild-type and CB1/CB2 receptor knockout mice .
24089490	0	dopamine	24,32	D2_receptor	94,105	dopamine	D2 receptor	MESH:D004298	13489(Tax:10090)	Chemical	Gene	START_ENTITY|xcomp|signaling signaling|nmod|D1 D1|nmod|END_ENTITY	Chronic cocaine dampens dopamine signaling during cocaine_intoxication and unbalances D1 over D2_receptor signaling .
10051542	0	dopamine	30,38	D3	39,41	dopamine	D3	MESH:D004298	1735	Chemical	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	G protein activation by human dopamine D3 receptors in high-expressing Chinese_hamster_ovary cells : A guanosine-5 ' - O - -LRB- 3 - -LSB- 35S -RSB- thio -RRB- - _ triphosphate binding and antibody study .
10722154	0	dopamine	85,93	D3	82,84	dopamine	D3	MESH:D004298	1735	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Benzamides derived from 1,2-diaminocyclopropane as novel ligands for human D2 and D3 dopamine receptors .
1330688	0	dopamine	30,38	D3	27,29	dopamine	D3	MESH:D004298	1735	Chemical	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Stable expression of human D3 dopamine receptors in GH4C1 pituitary cells .
7791116	0	dopamine	61,69	D3	74,76	dopamine	D3	MESH:D004298	1735	Chemical	Gene	START_ENTITY|dep|D2 D2|nummod|END_ENTITY	Antagonist properties of LY 165,163 at pre - and postsynaptic dopamine D2 , D3 and D1 receptors : modulation of agonist actions at 5-HT1A receptors in vivo .
8301582	0	dopamine	64,72	D3	61,63	dopamine	D3	MESH:D004298	1735	Chemical	Gene	START_ENTITY|nsubj|characterization characterization|nmod|END_ENTITY	Expression and pharmacological characterization of the human D3 dopamine receptor .
9849894	0	dopamine	9,17	D3	6,8	dopamine	D3	MESH:D004298	1735	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Human D3 dopamine receptor in the medulloblastoma TE671 cell line : cross-talk between D1_and_D3_receptors .
10340615	0	dopamine	92,100	D4	101,103	dopamine	D4	MESH:D004298	397	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	4-N-linked-heterocyclic_piperidine derivatives with high affinity and selectivity for human dopamine D4 receptors .
7777184	0	dopamine	75,83	D4	84,86	dopamine	D4	MESH:D004298	397	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Differential effects of -LSB- 3H -RSB- nemonapride and -LSB- 3H -RSB- spiperone binding on human dopamine D4 receptors .
7921596	0	dopamine	127,135	D4	124,126	dopamine	D4	MESH:D004298	397	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Pharmacology of high-threshold calcium currents in GH4C1 pituitary cells and their regulation by activation of human D2 and D4 dopamine receptors .
8200447	0	dopamine	82,90	D4	79,81	dopamine	D4	MESH:D004298	397	Chemical	Gene	START_ENTITY|nsubj|characterisation characterisation|nmod|version version|nmod|END_ENTITY	Expression and functional characterisation of a synthetic version of the human D4 dopamine receptor in a stable human cell line .
9502100	0	dopamine	53,61	D4	50,52	dopamine	D4	MESH:D004298	397	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Binding of 2,4-disubstituted _ morpholines at human D4 dopamine receptors .
12515216	0	dopamine	55,63	DA1	64,67	dopamine	DA1	MESH:D004298	28495	Chemical	Gene	START_ENTITY|dobj|subtypes subtypes|compound|END_ENTITY	-LSB- Effects of tetrahydroberberine on peripheral vascular dopamine DA1 and DA2 receptor subtypes -RSB- .
1671029	0	dopamine	10,18	DA1	19,22	dopamine	DA1	MESH:D004298	28495	Chemical	Gene	stimulation|amod|START_ENTITY stimulation|compound|END_ENTITY	Selective dopamine DA1 stimulation with fenoldopam in cirrhotic patients with ascites : a systemic , splanchnic and renal hemodynamic study .
1970961	0	dopamine	27,35	DA1	36,39	dopamine	DA1	MESH:D004298	28495	Chemical	Gene	fenoldopam|amod|START_ENTITY fenoldopam|compound|END_ENTITY	A preliminary study of the dopamine DA1 agonist fenoldopam in the treatment of chronic left_ventricular_failure due to ischaemic_heart_disease .
2573060	0	dopamine	59,67	DA1	68,71	dopamine	DA1	MESH:D004298	28495	Chemical	Gene	+|amod|START_ENTITY +|compound|END_ENTITY	Dopamine - _ and_cAMP-regulated_phosphoprotein -LRB- DARPP-32 -RRB- and dopamine DA1 agonist-sensitive Na + , K + - ATPase in renal tubule cells .
2867216	0	dopamine	36,44	DA1	94,97	dopamine	DA1	MESH:D004298	28495	Chemical	Gene	receptors|amod|START_ENTITY characterization|nmod|receptors characterization|nmod|ganglia ganglia|nmod|END_ENTITY	Pharmacological characterization of dopamine receptors in the stellate ganglia with selective DA1 and DA2 receptor agonists and antagonists .
2868748	0	dopamine	27,35	DA1	45,48	dopamine	DA1	MESH:D004298	28495	Chemical	Gene	agonist|amod|START_ENTITY agonist|compound|END_ENTITY	Studies with fenoldopam , a dopamine receptor DA1 agonist , in essential hypertension .
2874213	0	dopamine	31,39	DA1	14,17	dopamine	DA1	MESH:D004298	294269(Tax:10116)	Chemical	Gene	receptors|nmod|START_ENTITY receptors|nummod|END_ENTITY	Activation of DA1 receptors by dopamine or fenoldopam increases cyclic_AMP levels in the renal artery but not in the superior cervical ganglion of the rat .
3157074	0	dopamine	19,27	DA1	28,31	dopamine	DA1	MESH:D004298	294269(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	Fusion transfer of dopamine DA1 receptors to Friend erythroleukemia cells .
6152269	0	dopamine	97,105	DA1	92,95	dopamine	DA1	MESH:D004298	294269(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Evaluation Evaluation|nmod|effects effects|nmod|presynaptic presynaptic|appos|END_ENTITY	Evaluation of the effects of SKF_82526 and LY_171555 on presynaptic -LRB- DA2 -RRB- and postsynaptic -LRB- DA1 -RRB- dopamine receptors in rat kidney .
7712139	0	dopamine	37,45	DA1	46,49	dopamine	DA1	MESH:D004298	294269(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	In vivo evidence for a defect in the dopamine DA1 receptor in the prehypertensive Dahl salt-sensitive rat .
8381602	0	dopamine	40,48	DA1	49,52	dopamine	DA1	MESH:D004298	28495	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Interaction between a phorbol_ester and dopamine DA1 receptors on vascular smooth muscle .
8526852	0	dopamine	15,23	DA1	67,70	dopamine	DA1	MESH:D004298	28495	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|nmod|receptors receptors|compound|END_ENTITY	Locally formed dopamine modulates renal Na-Pi co-transport through DA1 and DA2 receptors .
9087677	0	dopamine	6,14	DA1	15,18	dopamine	DA1	MESH:D004298	294269(Tax:10116)	Chemical	Gene	START_ENTITY|iobj|coupling coupling|compound|END_ENTITY	Renal dopamine DA1 receptor coupling with G -LRB- S -RRB- and G -LRB- q/11 -RRB- proteins in spontaneously hypertensive rats .
9249591	0	dopamine	15,23	DA1	24,27	dopamine	DA1	MESH:D004298	294269(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Alterations in dopamine DA1 receptor and G proteins in renal proximal tubules of old rats .
10604473	0	dopamine	46,54	DARPP-32	19,27	dopamine	DARPP-32	MESH:D004298	19049(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons .
10898909	0	dopamine	17,25	DAT	68,71	dopamine	DAT	MESH:D004298	6531	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Investigation of dopamine receptor -LRB- DRD4 -RRB- and dopamine_transporter -LRB- DAT -RRB- polymorphisms for genetic linkage or association to panic_disorder .
15879005	0	dopamine	96,104	DAT	181,184	dopamine	DAT	MESH:D004298	6531	Chemical	Gene	uptake|compound|START_ENTITY that|nmod|uptake differs|nmod|that inhibitors|dep|differs inhibitors|nmod|function function|nmod|transmembrane transmembrane|compound|END_ENTITY	Recognition of benztropine by the dopamine_transporter -LRB- DAT -RRB- differs from that of the classical dopamine uptake inhibitors cocaine , methylphenidate , and mazindol as a function of a DAT transmembrane 1 aspartic_acid residue .
15879005	0	dopamine	96,104	DAT	56,59	dopamine	DAT	MESH:D004298	6531	Chemical	Gene	uptake|compound|START_ENTITY that|nmod|uptake differs|nmod|that differs|nsubj|Recognition Recognition|nmod|benztropine benztropine|nmod|dopamine_transporter dopamine_transporter|appos|END_ENTITY	Recognition of benztropine by the dopamine_transporter -LRB- DAT -RRB- differs from that of the classical dopamine uptake inhibitors cocaine , methylphenidate , and mazindol as a function of a DAT transmembrane 1 aspartic_acid residue .
16733058	0	dopamine	38,46	DAT	30,33	dopamine	DAT	MESH:D004298	788410(Tax:9913)	Chemical	Gene	transport|amod|START_ENTITY Role|nmod|transport Role|appos|END_ENTITY	Role of dopamine_transporter -LRB- DAT -RRB- in dopamine transport across the nasal mucosa .
19039936	0	dopamine	60,68	DAT	81,84	dopamine	DAT	MESH:D004298	24898(Tax:10116)	Chemical	Gene	protein|amod|START_ENTITY protein|compound|END_ENTITY	Effect of antiparkinsonian drug himantane on the content of dopamine transporter DAT protein in rat striatum and cultured pheochromocytoma PC-12 cells .
21741256	0	dopamine	53,61	DAT	127,130	dopamine	DAT	MESH:D004298	6531	Chemical	Gene	transporter|compound|START_ENTITY brain_injury|nmod|transporter Effects|nmod|brain_injury Effects|dep|evaluation evaluation|nmod|PET/CT PET/CT|nmod|quantification quantification|compound|END_ENTITY	Effects of hypoxic-ischemic brain_injury on striatal dopamine transporter in newborn piglets : evaluation of 11C-CFT PET/CT for DAT quantification .
22006250	0	dopamine	36,44	DAT	72,75	dopamine	DAT	MESH:D004298	6531	Chemical	Gene	expression|nmod|START_ENTITY transporters|nsubj|expression transporters|dobj|END_ENTITY	Differential expression of neuronal dopamine and serotonin transporters DAT and SERT in megakaryocytes and platelets generated from human MEG-01 megakaryoblasts .
22282456	0	dopamine	21,29	DAT	102,105	dopamine	DAT	MESH:D004298	6531	Chemical	Gene	START_ENTITY|dep|meta-analysis meta-analysis|nmod|density density|appos|END_ENTITY	Striatal presynaptic dopamine in schizophrenia , Part I : meta-analysis of dopamine_active_transporter -LRB- DAT -RRB- density .
22376027	0	dopamine	17,25	DAT	48,51	dopamine	DAT	MESH:D004298	13162(Tax:10090)	Chemical	Gene	reuptake|amod|START_ENTITY transporter|amod|reuptake transporter|appos|END_ENTITY	Knocking out the dopamine reuptake transporter -LRB- DAT -RRB- does not change the baseline brain arachidonic_acid signal in the mouse .
23313730	0	dopamine	27,35	DAT	71,74	dopamine	DAT	MESH:D004298	6531	Chemical	Gene	toxicity|amod|START_ENTITY manganese|nmod|toxicity effect|nmod|manganese effect|appos|END_ENTITY	The effect of manganese on dopamine toxicity and dopamine_transporter -LRB- DAT -RRB- in control and DAT transfected HEK cells .
23516454	0	dopamine	32,40	DAT	67,70	dopamine	DAT	MESH:D004298	24898(Tax:10116)	Chemical	Gene	reuptake|amod|START_ENTITY reduces|dobj|reuptake reduces|advcl|altering altering|dobj|expression expression|compound|END_ENTITY	Prolonged high fat diet reduces dopamine reuptake without altering DAT gene expression .
17457369	0	dopamine	66,74	DBH	45,48	dopamine	DBH	MESH:D004298	1621	Chemical	Gene	START_ENTITY|nsubj|associations associations|nmod|gene gene|compound|END_ENTITY	Genotypic and haplotypic associations of the DBH gene with plasma dopamine beta-hydroxylase activity in African Americans .
9390657	0	dopamine	44,52	DOPA_decarboxylase	22,40	dopamine	DOPA decarboxylase	MESH:D004298	24311(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY END_ENTITY|nmod|receptors	In vivo regulation of DOPA_decarboxylase by dopamine receptors in rat brain .
15607627	0	dopamine	59,67	DRD1	83,87	dopamine	DRD1	MESH:D004298	1812	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Ethnic origin determines the impact of genetic variants in dopamine receptor gene -LRB- DRD1 -RRB- concerning essential hypertension .
26909995	0	dopamine	7,15	DRD1	26,30	dopamine	DRD1	MESH:D004298	281125(Tax:9913)	Chemical	Gene	receptors|compound|START_ENTITY END_ENTITY|dep|receptors	Bovine dopamine receptors DRD1 , DRD4 , and DRD5 : genetic polymorphisms and diversities among ten cattle breeds .
26957229	0	dopamine	74,82	DRD1	40,44	dopamine	DRD1	MESH:D004298	1812	Chemical	Gene	START_ENTITY|nsubj|Associations Associations|nmod|gene gene|compound|END_ENTITY	Associations between a locus downstream DRD1 gene and cerebrospinal fluid dopamine metabolite concentrations in psychosis .
10023512	0	dopamine	26,34	DRD2	45,49	dopamine	DRD2	MESH:D004298	1813	Chemical	Gene	START_ENTITY|dobj|receptor receptor|appos|END_ENTITY	No association between D2 dopamine receptor -LRB- DRD2 -RRB- alleles or haplotypes and cocaine_dependence or severity of cocaine_dependence in European - and African-Americans .
10088049	0	dopamine	26,34	DRD2	45,49	dopamine	DRD2	MESH:D004298	1813	Chemical	Gene	START_ENTITY|dobj|receptor receptor|appos|END_ENTITY	No association between D2 dopamine receptor -LRB- DRD2 -RRB- `` A '' system alleles , or DRD2 haplotypes , and posttraumatic_stress_disorder .
10327432	0	dopamine	3,11	DRD2	27,31	dopamine	DRD2	MESH:D004298	1813	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	D2 dopamine receptor gene -LRB- DRD2 -RRB- allele and haplotype frequencies in alcohol dependent and control subjects : no association with phenotype or severity of phenotype .
10823405	0	dopamine	70,78	DRD2	153,157	dopamine	DRD2	MESH:D004298	1813	Chemical	Gene	receptors|amod|START_ENTITY D2|nmod|receptors antagonist|nmod|D2 response|appos|antagonist response|nmod|patients patients|nmod|relation relation|nmod|polymorphism polymorphism|nmod|gene gene|compound|END_ENTITY	Prolactin response to nemonapride , a selective antagonist for D2 like dopamine receptors , in schizophrenic patients in relation to Taq1A polymorphism of DRD2 gene .
11022024	0	dopamine	20,28	DRD2	38,42	dopamine	DRD2	MESH:D004298	1813	Chemical	Gene	allele|amod|START_ENTITY allele|compound|END_ENTITY	Alcoholics with the dopamine receptor DRD2 A1 allele have lower platelet monoamine_oxidase-B activity than those with the A2 allele : a preliminary study .
1832467	0	dopamine	43,51	DRD2	67,71	dopamine	DRD2	MESH:D004298	1813	Chemical	Gene	START_ENTITY|dobj|gene gene|appos|END_ENTITY	No association between an allele at the D2 dopamine receptor gene -LRB- DRD2 -RRB- and alcoholism .
19803686	0	dopamine	24,32	DRD2	33,37	dopamine	DRD2	MESH:D004298	1813	Chemical	Gene	polymorphisms|amod|START_ENTITY polymorphisms|compound|END_ENTITY	The association between dopamine DRD2 polymorphisms and working memory capacity is modulated by a functional polymorphism on the nicotinic receptor gene CHRNA4 .
20099571	0	dopamine	58,66	DRD2	71,75	dopamine	DRD2	MESH:D004298	1813	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|compound|END_ENTITY	Development of a high-throughput method for screening the dopamine D2 -LRB- DRD2 -RRB- receptor gene polymorphisms based on the LightCycler system .
20410253	0	dopamine	2,10	DRD2	17,21	dopamine	DRD2	MESH:D004298	1813	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A dopamine gene -LRB- DRD2 -RRB- distinguishes between offenders who have and have not been violently victimized .
21592505	0	dopamine	2,10	DRD2	21,25	dopamine	DRD2	MESH:D004298	1813	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	A dopamine receptor -LRB- DRD2 -RRB- but not dopamine_transporter -LRB- DAT1 -RRB- gene polymorphism is associated with neurocognitive development of Mexican preschool children with lead exposure .
26370377	0	dopamine	45,53	DRD2	64,68	dopamine	DRD2	MESH:D004298	1813	Chemical	Gene	genotype|amod|START_ENTITY genotype|appos|END_ENTITY	Recurrent miscarriage is associated with the dopamine receptor -LRB- DRD2 -RRB- genotype .
26735638	0	dopamine	41,49	DRD2	60,64	dopamine	DRD2	MESH:D004298	1813	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Frequency of the A1/A2 alleles of the D2 dopamine receptor -LRB- DRD2 -RRB- gene in a British , Caucasian control group screened to exclude alcoholism and heavy drinking .
7748310	0	dopamine	9,17	DRD2	4,8	dopamine	DRD2	MESH:D004298	1813	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	The DRD2 dopamine receptor and the candidate gene approach in alcoholism .
7910578	0	dopamine	32,40	DRD2	57,61	dopamine	DRD2	MESH:D004298	1813	Chemical	Gene	START_ENTITY|dobj|locus locus|appos|END_ENTITY	Linkage disequilibria at the D2 dopamine receptor locus -LRB- DRD2 -RRB- in alcoholics and controls .
8873216	0	dopamine	51,59	DRD2	75,79	dopamine	DRD2	MESH:D004298	1813	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Increased prevalence of the Taq I A1 allele of the dopamine receptor gene -LRB- DRD2 -RRB- in obesity with comorbid substance_use_disorder : a preliminary report .
8907305	0	dopamine	119,127	DRD2	145,149	dopamine	DRD2	MESH:D004298	1813	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Allele-specific PCR for simultaneous amplification of both alleles of a deletion polymorphism in intron 6 of the human dopamine 2 receptor gene -LRB- DRD2 -RRB- .
9191771	0	dopamine	60,68	DRD2	153,157	dopamine	DRD2	MESH:D004298	1813	Chemical	Gene	pathway|amod|START_ENTITY proteins|nmod|pathway encoding|dobj|proteins genes|acl|encoding Evaluation|nmod|genes Evaluation|dep|evidence evidence|nmod|association association|nmod|allele allele|compound|END_ENTITY	Evaluation of four candidate genes encoding proteins of the dopamine pathway in familial and sporadic Parkinson 's _ disease : evidence for association of a DRD2 allele .
9429233	0	dopamine	3,11	DRD2	27,31	dopamine	DRD2	MESH:D004298	1813	Chemical	Gene	Taq1|amod|START_ENTITY Taq1|appos|END_ENTITY	D2 dopamine receptor gene -LRB- DRD2 -RRB- Taq1 A polymorphism : reduced dopamine_D2_receptor binding in the human striatum associated with the A1 allele .
10523822	0	dopamine	20,28	DRD3	29,33	dopamine	DRD3	MESH:D004298	1814	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Homozygosity at the dopamine DRD3 receptor gene in cocaine_dependence .
10670776	0	dopamine	75,83	DRD3	102,106	dopamine	DRD3	MESH:D004298	1814	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A cluster of single nucleotide polymorphisms in the 5 ' - leader of the human dopamine D3 receptor gene -LRB- DRD3 -RRB- and its relationship to schizophrenia .
10697826	0	dopamine	24,32	DRD3	57,61	dopamine	DRD3	MESH:D004298	1814	Chemical	Gene	gene|amod|START_ENTITY Association|nmod|gene locus|nsubj|Association locus|dobj|END_ENTITY	Association between the dopamine D3 receptor gene locus -LRB- DRD3 -RRB- and unipolar affective_disorder .
10893495	0	dopamine	15,23	DRD3	149,153	dopamine	DRD3	MESH:D004298	1814	Chemical	Gene	variants|amod|START_ENTITY Association|nmod|variants Association|dep|generalization generalization|nmod|study study|nmod|END_ENTITY	Association of dopamine D3-receptor gene variants with neuroleptic induced akathisia in schizophrenic patients : a generalization of Steen 's study on DRD3 and tardive_dyskinesia .
15342129	0	dopamine	93,101	DRD3	111,115	dopamine	DRD3	MESH:D004298	1814	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Psychotic_symptoms in Alzheimer 's _ disease are not influenced by polymorphic variation at the dopamine receptor DRD3 gene .
16395310	0	dopamine	30,38	DRD3	57,61	dopamine	DRD3	MESH:D004298	1814	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A Ser9Gly polymorphism in the dopamine D3 receptor gene -LRB- DRD3 -RRB- and event-related P300 potentials .
19931559	6	dopamine	1096,1104	DRD3	1112,1116	dopamine	UCP2	MESH:D004298	7351	Chemical	Gene	catecholamine-O-methyl_transferase|compound|START_ENTITY catecholamine-O-methyl_transferase|dep|END_ENTITY	-LRB- 3 -RRB- Feeding motivation - and reward-related systems -LRB- opioids , OPRD1 , cannabinoids -LRB- anandamide -LRB- AEA -RRB- , THC , CBR1 -RRB- , dopamine , DRD2 , DRD3 , DRD4 , catecholamine-O-methyl_transferase -LRB- COMT -RRB- .
23232665	4	dopamine	682,690	DRD3	714,718	dopamine	5HTT	MESH:D004298	6532	Chemical	Gene	receptors|amod|START_ENTITY receptors|appos|DRD1 DRD1|dep|DRD4 DRD4|compound|END_ENTITY	Recent genetic studies have investigated associations between ICD and polymorphisms of genes involved in the dopamine metabolism pathway -LRB- COMT , DAT -RRB- , dopamine receptors -LRB- DRD1 , DRD2 , DRD3 , DRD4 -RRB- , serotonin receptors and its transporter -LRB- HTR2A , 5HTT -RRB- , and glutamate receptors -LRB- GRIN2B -RRB- .
10898897	0	dopamine	22,30	DRD4	46,50	dopamine	DRD4	MESH:D004298	1815	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	No association of the dopamine DRD4 receptor -LRB- DRD4 -RRB- gene polymorphism with attention deficit_hyperactivity_disorder -LRB- ADHD -RRB- in the Irish population .
10898909	0	dopamine	17,25	DRD4	36,40	dopamine	DRD4	MESH:D004298	1815	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Investigation of dopamine receptor -LRB- DRD4 -RRB- and dopamine_transporter -LRB- DAT -RRB- polymorphisms for genetic linkage or association to panic_disorder .
11054777	0	dopamine	18,26	DRD4	37,41	dopamine	DRD4	MESH:D004298	1815	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Long forms of the dopamine receptor -LRB- DRD4 -RRB- gene VNTR are more prevalent in substance abusers : no interaction with functional alleles of the catechol-o-methyltransferase -LRB- COMT -RRB- gene .
12860364	0	dopamine	167,175	DRD4	186,190	dopamine	DRD4	MESH:D004298	1815	Chemical	Gene	polymorphisms|amod|START_ENTITY polymorphisms|appos|END_ENTITY	Gene-environment interaction in psychiatric_disorders as indicated by season of birth variations in tryptophan hydroxylase -LRB- TPH -RRB- , serotonin transporter -LRB- 5-HTTLPR -RRB- and dopamine receptor -LRB- DRD4 -RRB- gene polymorphisms .
1349574	0	dopamine	7,15	DRD4	26,30	dopamine	DRD4	MESH:D004298	1815	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	The D4 dopamine receptor -LRB- DRD4 -RRB- maps to distal 11p close to HRAS .
15288435	0	dopamine	118,126	DRD4	137,141	dopamine	DRD4	MESH:D004298	1815	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Gene-environment interaction in hyperkinetic conduct_disorder -LRB- HD + CD -RRB- as indicated by season of birth variations in dopamine receptor -LRB- DRD4 -RRB- gene polymorphism .
18715282	0	dopamine	4,12	DRD4	25,29	dopamine	DRD4	MESH:D004298	1815	Chemical	Gene	exon|amod|START_ENTITY exon|appos|END_ENTITY	The dopamine D Receptor -LRB- DRD4 -RRB- gene exon III polymorphism , problematic alcohol use and novelty seeking : direct and mediated genetic effects .
20150884	0	dopamine	10,18	DRD4	19,23	dopamine	DRD4	MESH:D004298	1815	Chemical	Gene	START_ENTITY|dobj|expression expression|compound|END_ENTITY	Increased dopamine DRD4 receptor mRNA expression in lymphocytes of musicians and autistic individuals : bridging the music-autism connection .
24611835	0	dopamine	27,35	DRD4	46,50	dopamine	DRD4	MESH:D004298	1815	Chemical	Gene	receptor|amod|START_ENTITY association|nmod|receptor association|appos|END_ENTITY	Interactive association of dopamine receptor -LRB- DRD4 -RRB- genotype and ADHD on alcohol expectancies in children .
24825354	0	dopamine	24,32	DRD4	43,47	dopamine	DRD4	MESH:D004298	100546496	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	The association between dopamine receptor -LRB- DRD4 -RRB- gene polymorphisms and second language learning style and behavioral variability in undergraduate students in Turkey .
7909310	0	dopamine	59,67	DRD4	83,87	dopamine	DRD4	MESH:D004298	1815	Chemical	Gene	START_ENTITY|dobj|gene gene|appos|END_ENTITY	A SmaI PCR-RFLP in the 5 ' noncoding region of the human D4 dopamine receptor gene -LRB- DRD4 -RRB- .
7914460	0	dopamine	19,27	DRD4	38,42	dopamine	DRD4	MESH:D004298	1815	Chemical	Gene	START_ENTITY|dobj|receptor receptor|appos|END_ENTITY	Analysis of new D4 dopamine receptor -LRB- DRD4 -RRB- coding region variants and TH microsatellite in the Old Order Amish family -LRB- OOA110 -RRB- .
9433345	0	dopamine	54,62	DRD4	78,82	dopamine	DRD4	MESH:D004298	1815	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	No association between novelty seeking and the type 4 dopamine receptor gene -LRB- DRD4 -RRB- in two New Zealand samples .
10720299	0	dopamine	9,17	DYT1	67,71	dopamine	DYT1	MESH:D004298	1861	Chemical	Gene	START_ENTITY|nmod|mutation mutation|compound|END_ENTITY	Striatal dopamine in early-onset primary_torsion_dystonia with the DYT1 mutation .
16490190	0	dopamine	35,43	Dopamine_D3_receptor	0,20	dopamine	Dopamine D3 receptor	MESH:D004298	29238(Tax:10116)	Chemical	Gene	efflux|amod|START_ENTITY modulation|nmod|efflux modulation|amod|END_ENTITY	Dopamine_D3_receptor modulation of dopamine efflux in the rat nucleus accumbens .
26383990	0	dopamine	76,84	Dopamine_D3_receptor	0,20	dopamine	Dopamine D3 receptor	MESH:D004298	29238(Tax:10116)	Chemical	Gene	contributes|nmod|START_ENTITY contributes|nsubj|antagonism antagonism|compound|END_ENTITY	Dopamine_D3_receptor antagonism contributes to blonanserin-induced cortical dopamine and acetylcholine efflux and cognitive improvement .
7766866	0	dopamine	42,50	Dopamine_D3_receptor	0,20	dopamine	Dopamine D3 receptor	MESH:D004298	29238(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY influences|dobj|synthesis influences|nsubj|antisense antisense|amod|END_ENTITY	Dopamine_D3_receptor antisense influences dopamine synthesis in rat brain .
20975260	0	dopamine	55,63	Drd2	93,97	dopamine	Drd2	MESH:D004298	13489(Tax:10090)	Chemical	Gene	receptors|amod|START_ENTITY roles|nmod|receptors insights|nmod|roles gained|nsubj|insights gained|nmod|mouse mouse|amod|END_ENTITY	New insights into the endocrine and metabolic roles of dopamine D2 receptors gained from the Drd2 mouse .
26787837	0	dopamine	35,43	Drd3	44,48	dopamine	Drd3	MESH:D004298	1814	Chemical	Gene	START_ENTITY|dobj|trafficking trafficking|amod|END_ENTITY	A GIPC1-palmitate switch modulates dopamine Drd3 receptor trafficking and signaling .
25033183	0	dopamine	109,117	EAAT3	100,105	dopamine	EAAT3	MESH:D004298	6505	Chemical	Gene	neurons|amod|START_ENTITY END_ENTITY|nmod|neurons	Amphetamine modulates excitatory neurotransmission through endocytosis of the glutamate transporter EAAT3 in dopamine neurons .
12470865	0	dopamine	89,97	EGR-1	6,11	dopamine	EGR-1	MESH:D004298	1958	Chemical	Gene	role|nmod|START_ENTITY expression|dep|role expression|compound|END_ENTITY	Basal EGR-1 -LRB- zif268 , NGFI-A , Krox-24 -RRB- expression in developing striatal patches : role of dopamine and glutamate .
20029831	0	dopamine	8,16	ERK	53,56	dopamine	ERK	MESH:D004298	24338(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|nmod|END_ENTITY	Role of dopamine D -LRB- 1 -RRB- receptors in caffeine-mediated ERK phosphorylation in the rat brain .
25322796	0	dopamine	82,90	ERK	22,25	dopamine	ERK	MESH:D004298	24338(Tax:10116)	Chemical	Gene	activation|compound|START_ENTITY requires|dobj|activation requires|nsubj|END_ENTITY	Appetitive cue-evoked ERK signaling in the nucleus accumbens requires NMDA and D1 dopamine receptor activation and regulates CREB phosphorylation .
3135174	0	dopamine	20,28	Enkephalin	0,10	dopamine	Enkephalin	MESH:D004298	29237(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY inhibits|dobj|synthesis inhibits|nsubj|END_ENTITY	Enkephalin inhibits dopamine synthesis in vitro in the median eminence portion of rat hypothalamic slices .
3620936	0	dopamine	106,114	Enkephalin	0,10	dopamine	Enkephalin	MESH:D004298	29237(Tax:10116)	Chemical	Gene	modulation|nmod|START_ENTITY release|dep|modulation release|compound|END_ENTITY	Enkephalin release into the ventral tegmental area in response to stress : modulation of mesocorticolimbic dopamine .
1670924	0	dopamine	61,69	Epidermal_growth_factor	0,23	dopamine	Epidermal growth factor	MESH:D004298	25313(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY expression|nmod|receptors induces|dobj|expression induces|nsubj|END_ENTITY	Epidermal_growth_factor induces the functional expression of dopamine receptors in the GH3 cell line .
8145892	0	dopamine	45,53	Epidermal_growth_factor	0,23	dopamine	Epidermal growth factor	MESH:D004298	25313(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY induces|dobj|receptors induces|nsubj|treatment treatment|amod|END_ENTITY	Epidermal_growth_factor treatment induces D2 dopamine receptors functionally coupled to delayed outward potassium current -LRB- IK -RRB- in GH4C1 clonal anterior pituitary cells .
19336245	0	dopamine	40,48	ErbB4	14,19	dopamine	ErbB4	MESH:D004298	2066	Chemical	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of ErbB4 in substantia nigra dopamine neurons of monkeys and humans .
10095045	0	dopamine	11,19	Fos	73,76	dopamine	Fos	MESH:D004298	2353	Chemical	Gene	depletion|compound|START_ENTITY enhances|nsubj|depletion enhances|dobj|expression expression|compound|END_ENTITY	Unilateral dopamine depletion paradoxically enhances amphetamine-induced Fos expression in basal ganglia output structures .
10366018	0	dopamine	126,134	Fos	68,71	dopamine	Fos	MESH:D004298	314322(Tax:10116)	Chemical	Gene	function|amod|START_ENTITY areas|nmod|function increases|nmod|areas increases|dobj|expression expression|compound|END_ENTITY	Blockade of cannabinoid receptors by SR141716 selectively increases Fos expression in rat mesocorticolimbic areas via reduced dopamine D2 function .
10579212	0	dopamine	9,17	Fos	81,84	dopamine	Fos	MESH:D004298	314322(Tax:10116)	Chemical	Gene	stimulation|compound|START_ENTITY required|nsubjpass|stimulation required|nmod|expression expression|compound|END_ENTITY	Prior D1 dopamine receptor stimulation is required to prime D2-mediated striatal Fos expression in 6-hydroxydopamine-lesioned rats .
10594656	0	dopamine	70,78	Fos	18,21	dopamine	Fos	MESH:D004298	314322(Tax:10116)	Chemical	Gene	blockade|amod|START_ENTITY amplified|nmod|blockade amplified|nsubjpass|induction induction|compound|END_ENTITY	Cortically driven Fos induction in the striatum is amplified by local dopamine D2-class receptor blockade .
11997149	0	dopamine	23,31	Fos	71,74	dopamine	Fos	MESH:D004298	314322(Tax:10116)	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|nmod|expression expression|compound|END_ENTITY	Contrasting effects of dopamine antagonists and frequency reduction on Fos expression induced by lateral hypothalamic stimulation .
12039421	0	dopamine	69,77	Fos	0,3	dopamine	Fos	MESH:D004298	314322(Tax:10116)	Chemical	Gene	deficiency|compound|START_ENTITY brain|nmod|deficiency synthase|nmod|brain synthase|compound|END_ENTITY	Fos and nitric_oxide synthase in rat brain with chronic mesostriatal dopamine deficiency : effects of nitroglycerin and hypoxia .
16324697	0	dopamine	13,21	Fos	69,72	dopamine	Fos	MESH:D004298	314322(Tax:10116)	Chemical	Gene	SKF_83959|amod|START_ENTITY induces|nsubj|SKF_83959 induces|dobj|expression expression|compound|END_ENTITY	The atypical dopamine D1 receptor agonist SKF_83959 induces striatal Fos expression in rats .
17027163	0	dopamine	17,25	Fos	0,3	dopamine	Fos	MESH:D004298	2353	Chemical	Gene	responses|nmod|START_ENTITY responses|compound|END_ENTITY	Fos responses of dopamine neurons to sociosexual stimuli in male zebra finches .
18822274	0	dopamine	11,19	Fos	58,61	dopamine	Fos	MESH:D004298	314322(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY Effects|nmod|receptors Effects|nmod|expression expression|compound|END_ENTITY	Effects of dopamine and NMDA receptors on cocaine-induced Fos expression in the striatum of Fischer rats .
19374938	0	dopamine	9,17	Fos	84,87	dopamine	Fos	MESH:D004298	314322(Tax:10116)	Chemical	Gene	modulate|nsubj|START_ENTITY modulate|dobj|expression expression|compound|END_ENTITY	Striatal dopamine and glutamate receptors modulate methamphetamine-induced cortical Fos expression .
7845612	0	dopamine	31,39	Fos	104,107	dopamine	Fos	MESH:D004298	314322(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY development|nmod|receptor indicated|nsubj|development indicated|nmod|expression expression|compound|END_ENTITY	Rapid development of D1_and_D2 dopamine receptor supersensitivity as indicated by striatal and pallidal Fos expression .
8102797	0	dopamine	41,49	Fos	9,12	dopamine	Fos	MESH:D004298	314322(Tax:10116)	Chemical	Gene	synergism|amod|START_ENTITY indicative|nmod|synergism indicative|nsubj|expression expression|compound|END_ENTITY	Striatal Fos expression is indicative of dopamine D1/D2 synergism and receptor supersensitivity .
8309528	0	dopamine	102,110	Fos	194,197	dopamine	Fos	MESH:D004298	314322(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY antagonism|nmod|receptor antagonism|dep|study study|acl|using using|dobj|antibodies antibodies|nmod|END_ENTITY	Subsets of neurotensin-immunoreactive neurons in the rat striatal complex following antagonism of the dopamine D2 receptor : an immunohistochemical double-labeling study using antibodies against Fos .
8497810	0	dopamine	91,99	Fos	23,26	dopamine	Fos	MESH:D004298	2353	Chemical	Gene	fields|amod|START_ENTITY immunoreactivity|nmod|fields immunoreactivity|nsubj|induction induction|nmod|END_ENTITY	Selective induction of Fos and FRA immunoreactivity within the mesolimbic and mesostriatal dopamine terminal fields .
8719628	0	dopamine	3,11	Fos	32,35	dopamine	Fos	MESH:D004298	314322(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY influence|nsubj|receptors influence|dobj|immunoreactivity immunoreactivity|compound|END_ENTITY	D1 dopamine receptors influence Fos immunoreactivity in the globus pallidus and subthalamic nucleus of intact and nigrostriatal-lesioned rats .
8963664	0	dopamine	9,17	Fos	85,88	dopamine	Fos	MESH:D004298	314322(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY Roles|nmod|receptors Roles|nmod|expression expression|nmod|protein protein|compound|END_ENTITY	Roles of dopamine D1 receptors in delta 9-tetrahydrocannabinol-induced expression of Fos protein in the rat brain .
9098550	0	dopamine	48,56	Fos	70,73	dopamine	Fos	MESH:D004298	314322(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Interactive effects of stimulation of D1 and D2 dopamine receptors on Fos expression in the lateral habenula .
9181492	0	dopamine	3,11	Fos	54,57	dopamine	Fos	MESH:D004298	314322(Tax:10116)	Chemical	Gene	agonist|amod|START_ENTITY induction|nsubj|agonist induction|nmod|END_ENTITY	D1 dopamine receptor agonist -LRB- SKF-38393 -RRB- induction of Fos immunoreactivity in progestin receptor-containing areas of female rat brain .
9300403	0	dopamine	24,32	Fos	61,64	dopamine	Fos	MESH:D004298	314322(Tax:10116)	Chemical	Gene	agonists|amod|START_ENTITY agonists|nmod|expression expression|compound|END_ENTITY	Differing influences of dopamine agonists and antagonists on Fos expression in identified populations of globus pallidus neurons .
9450515	0	dopamine	3,11	Fos	50,53	dopamine	Fos	MESH:D004298	314322(Tax:10116)	Chemical	Gene	START_ENTITY|ccomp|mediate mediate|dobj|expression expression|compound|END_ENTITY	D1 dopamine receptors mediate neuroleptic-induced Fos expression in the islands of Calleja .
9548387	0	dopamine	51,59	Fos	16,19	dopamine	Fos	MESH:D004298	314322(Tax:10116)	Chemical	Gene	SKF-82958|amod|START_ENTITY induced|nmod|SKF-82958 expression|acl|induced expression|compound|END_ENTITY	MK-801 reverses Fos expression induced by the full dopamine D1 receptor agonist SKF-82958 in the rat striatum .
9651118	0	dopamine	15,23	Fos	47,50	dopamine	Fos	MESH:D004298	314322(Tax:10116)	Chemical	Gene	D1|amod|START_ENTITY D1|nmod|END_ENTITY	Involvement of dopamine D1 and D2 receptors in Fos immunoreactivity induced by stepholidine in both intact and denervated striatum of lesioned rats .
8419540	0	dopamine	48,56	GAP-43	10,16	dopamine	GAP-43	MESH:D004298	29423(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY inhibits|dobj|release inhibits|nsubj|END_ENTITY	Antisense GAP-43 inhibits the evoked release of dopamine from PC12 cells .
10320698	0	dopamine	55,63	GDNF	76,80	dopamine	GDNF	MESH:D004298	25453(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|administration administration|compound|END_ENTITY	Augmented methamphetamine-induced overflow of striatal dopamine 1 day after GDNF administration .
11069582	0	dopamine	43,51	GDNF	63,67	dopamine	GDNF	MESH:D004298	2668	Chemical	Gene	pathway|compound|START_ENTITY pathway|nmod|END_ENTITY	Preservation of a functional nigrostriatal dopamine pathway by GDNF in the intrastriatal 6-OHDA lesion model depends on the site of administration of the trophic factor .
11085315	0	dopamine	40,48	GDNF	23,27	dopamine	GDNF	MESH:D004298	25453(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY END_ENTITY|nmod|release	Restorative effects of GDNF on striatal dopamine release in rats treated with neurotoxic doses of methamphetamine .
25101543	0	dopamine	88,96	GDNF	10,14	dopamine	GDNF	MESH:D004298	14573(Tax:10090)	Chemical	Gene	system|compound|START_ENTITY Effect|nmod|system Effect|nmod|END_ENTITY	Effect of GDNF on depressive-like behavior , spatial learning and key genes of the brain dopamine system in genetically predisposed to behavioral_disorders mouse strains .
26531360	0	dopamine	28,36	GDNF	10,14	dopamine	GDNF	MESH:D004298	14573(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of GDNF on the brain dopamine system in genetically predisposed to behavioral_disorders mouse strains .
8987838	0	dopamine	26,34	GDNF	0,4	dopamine	GDNF	MESH:D004298	25453(Tax:10116)	Chemical	Gene	neurons|amod|START_ENTITY protects|dobj|neurons protects|nsubj|END_ENTITY	GDNF selectively protects dopamine neurons over serotonin neurons against the neurotoxic effects of methamphetamine .
9952418	0	dopamine	91,99	GDNF	0,4	dopamine	GDNF	MESH:D004298	25453(Tax:10116)	Chemical	Gene	protection|nmod|START_ENTITY protection|amod|END_ENTITY	GDNF protection against 6-OHDA-induced reductions in potassium-evoked overflow of striatal dopamine .
18973577	0	dopamine	18,26	GFRalpha-1	43,53	dopamine	GFRalpha-1	MESH:D004298	14585(Tax:10090)	Chemical	Gene	system|compound|START_ENTITY system|nmod|END_ENTITY	The nigrostriatal dopamine system of aging GFRalpha-1 heterozygous mice : neurochemistry , morphology and behavior .
3553220	0	dopamine	64,72	GH	115,117	dopamine	GH	MESH:D004298	2688	Chemical	Gene	growth_hormone|amod|START_ENTITY growth_hormone|appos|END_ENTITY	Role of dopamine in the regulation of growth_hormone secretion : dopamine and bromocriptine augment growth_hormone -LRB- GH -RRB- - releasing hormone-stimulated GH secretion in normal man .
3553220	0	dopamine	64,72	GH	148,150	dopamine	GH	MESH:D004298	2688	Chemical	Gene	growth_hormone|amod|START_ENTITY Role|dep|growth_hormone Role|dep|secretion secretion|compound|END_ENTITY	Role of dopamine in the regulation of growth_hormone secretion : dopamine and bromocriptine augment growth_hormone -LRB- GH -RRB- - releasing hormone-stimulated GH secretion in normal man .
3553220	0	dopamine	8,16	GH	115,117	dopamine	GH	MESH:D004298	2688	Chemical	Gene	Role|nmod|START_ENTITY Role|dep|growth_hormone growth_hormone|appos|END_ENTITY	Role of dopamine in the regulation of growth_hormone secretion : dopamine and bromocriptine augment growth_hormone -LRB- GH -RRB- - releasing hormone-stimulated GH secretion in normal man .
3553220	0	dopamine	8,16	GH	148,150	dopamine	GH	MESH:D004298	2688	Chemical	Gene	Role|nmod|START_ENTITY Role|dep|secretion secretion|compound|END_ENTITY	Role of dopamine in the regulation of growth_hormone secretion : dopamine and bromocriptine augment growth_hormone -LRB- GH -RRB- - releasing hormone-stimulated GH secretion in normal man .
6664211	0	dopamine	31,39	GH	10,12	dopamine	GH	MESH:D004298	2688	Chemical	Gene	responsiveness|xcomp|START_ENTITY responsiveness|nsubj|END_ENTITY	Increased GH responsiveness to dopamine receptor stimulation in alcohol addicts during the late withdrawal_syndrome .
7096541	0	dopamine	105,113	GH	128,130	dopamine	GH	MESH:D004298	2688	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|secretion secretion|compound|END_ENTITY	Evidence of dopamine receptors in human growth_hormone -LRB- GH -RRB- - secreting adenomas with concomitant study of dopamine inhibition of GH secretion in a perifusion system .
7096541	0	dopamine	105,113	GH	56,58	dopamine	GH	MESH:D004298	2688	Chemical	Gene	inhibition|amod|START_ENTITY adenomas|nmod|inhibition Evidence|dep|adenomas Evidence|nmod|receptors receptors|nmod|growth_hormone growth_hormone|appos|END_ENTITY	Evidence of dopamine receptors in human growth_hormone -LRB- GH -RRB- - secreting adenomas with concomitant study of dopamine inhibition of GH secretion in a perifusion system .
7096541	0	dopamine	12,20	GH	128,130	dopamine	GH	MESH:D004298	2688	Chemical	Gene	receptors|amod|START_ENTITY Evidence|nmod|receptors Evidence|dep|adenomas adenomas|nmod|inhibition inhibition|nmod|secretion secretion|compound|END_ENTITY	Evidence of dopamine receptors in human growth_hormone -LRB- GH -RRB- - secreting adenomas with concomitant study of dopamine inhibition of GH secretion in a perifusion system .
7096541	0	dopamine	12,20	GH	56,58	dopamine	GH	MESH:D004298	2688	Chemical	Gene	receptors|amod|START_ENTITY receptors|nmod|growth_hormone growth_hormone|appos|END_ENTITY	Evidence of dopamine receptors in human growth_hormone -LRB- GH -RRB- - secreting adenomas with concomitant study of dopamine inhibition of GH secretion in a perifusion system .
7107817	0	dopamine	19,27	GH	47,49	dopamine	GH	MESH:D004298	2688	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	In vitro effect of dopamine on growth_hormone -LRB- GH -RRB- release from human GH-secreting_pituitary_adenomas .
7566482	0	dopamine	24,32	GM1	43,46	dopamine	GM1	MESH:D004298	210582(Tax:10090)	Chemical	Gene	system|compound|START_ENTITY system|nmod|END_ENTITY	Response of the damaged dopamine system to GM1 and semisynthetic gangliosides : effects of dose and extent of lesion .
9786976	0	dopamine	39,47	Galphao	24,31	dopamine	Galphao	MESH:D004298	14681(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|activation activation|nmod|END_ENTITY	Selective activation of Galphao by D2L dopamine receptors in NS20Y neuroblastoma cells .
12629203	0	dopamine	70,78	Glial_cell_line-derived_neurotrophic_factor	0,43	dopamine	Glial cell line-derived neurotrophic factor	MESH:D004298	706345(Tax:9544)	Chemical	Gene	release|compound|START_ENTITY increases|dobj|release increases|nsubj|END_ENTITY	Glial_cell_line-derived_neurotrophic_factor increases stimulus-evoked dopamine release and motor speed in aged rhesus_monkeys .
16935271	0	dopamine	60,68	Glial_cell_line-derived_neurotrophic_factor	0,43	dopamine	Glial cell line-derived neurotrophic factor	MESH:D004298	25453(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY enhances|dobj|release enhances|nsubj|END_ENTITY	Glial_cell_line-derived_neurotrophic_factor -LRB- GDNF -RRB- enhances dopamine release from striatal nerve endings in an adenosine_A2A_receptor-dependent manner .
17187291	0	dopamine	83,91	Growth_hormone	0,14	dopamine	Growth hormone	MESH:D004298	2688	Chemical	Gene	transporter|compound|START_ENTITY correlates|nmod|transporter correlates|nsubj|response response|amod|END_ENTITY	Growth_hormone response in low-dose apomorphine test correlates with nigrostriatal dopamine transporter binding in patients with Parkinson 's _ disease .
2664540	0	dopamine	42,50	Growth_hormone	0,14	dopamine	Growth hormone	MESH:D004298	2688	Chemical	Gene	agonist|amod|START_ENTITY apomorphine|appos|agonist END_ENTITY|nmod|apomorphine	Growth_hormone response to apomorphine , a dopamine receptor agonist , in normal aging and in dementia of the Alzheimer_type .
7962286	0	dopamine	56,64	Growth_hormone	0,14	dopamine	Growth hormone	MESH:D004298	2688	Chemical	Gene	effect|nmod|START_ENTITY secretion|dep|effect secretion|amod|END_ENTITY	Growth_hormone secretion in critical_illness : effect of dopamine .
26894890	0	dopamine	15,23	IGF-1	0,5	dopamine	IGF-1	MESH:D004298	24482(Tax:10116)	Chemical	Gene	neurons|amod|START_ENTITY protects|dobj|neurons protects|nsubj|END_ENTITY	IGF-1 protects dopamine neurons against oxidative stress : association with changes in phosphokinases .
8572200	0	dopamine	31,39	Interleukin-1_alpha	0,19	dopamine	Interleukin-1 alpha	MESH:D004298	24493(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Interleukin-1_alpha stimulates dopamine release by activating type II protein kinase A in PC-12 cells .
10720276	0	dopamine	19,27	JNCL	51,55	dopamine	JNCL	MESH:D004298	1201	Chemical	Gene	START_ENTITY|nmod|patients patients|amod|END_ENTITY	Decreased striatal dopamine transporter density in JNCL patients with parkinsonian_symptoms .
10191339	0	dopamine	82,90	L-amino_acid_decarboxylase	47,73	dopamine	L-amino acid decarboxylase	MESH:D004298	24311(Tax:10116)	Chemical	Gene	delivery|amod|START_ENTITY enhance|dobj|delivery enhance|nsubj|END_ENTITY	Vesicular_monoamine_transporter-2 and aromatic L-amino_acid_decarboxylase enhance dopamine delivery after L-3 , _ 4-dihydroxyphenylalanine administration in Parkinsonian rats .
10619466	0	dopamine	181,189	L-amino_acid_decarboxylase	57,83	dopamine	L-amino acid decarboxylase	MESH:D004298	24311(Tax:10116)	Chemical	Gene	independent|advmod|START_ENTITY evidence|acl:relcl|independent effects|dep|evidence effects|dep|dihydroxyphenylalanine dihydroxyphenylalanine|nmod|release release|amod|END_ENTITY	Dual effects of L-3 ,4 - dihydroxyphenylalanine on aromatic L-amino_acid_decarboxylase , dopamine release and motor stimulation in the reserpine-treated rat : evidence that behaviour is dopamine independent .
10619466	0	dopamine	85,93	L-amino_acid_decarboxylase	57,83	dopamine	L-amino acid decarboxylase	MESH:D004298	24311(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY release|amod|END_ENTITY	Dual effects of L-3 ,4 - dihydroxyphenylalanine on aromatic L-amino_acid_decarboxylase , dopamine release and motor stimulation in the reserpine-treated rat : evidence that behaviour is dopamine independent .
1729407	0	dopamine	53,61	L-amino_acid_decarboxylase	23,49	dopamine	L-amino acid decarboxylase	MESH:D004298	24311(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY Regulation|nmod|receptors Regulation|nmod|END_ENTITY	Regulation of aromatic L-amino_acid_decarboxylase by dopamine receptors in the rat brain .
20832343	0	dopamine	8,16	L-amino_acid_decarboxylase	29,55	dopamine	L-amino acid decarboxylase	MESH:D004298	1644	Chemical	Gene	START_ENTITY|nmod|deficiency deficiency|amod|END_ENTITY	Urinary dopamine in aromatic L-amino_acid_decarboxylase deficiency : the unsolved paradox .
7697371	0	dopamine	68,76	L-amino_acid_decarboxylase	157,183	dopamine	L-amino acid decarboxylase	MESH:D004298	24311(Tax:10116)	Chemical	Gene	produce|xcomp|START_ENTITY evidence|dep|produce L-DOPA|nsubj|evidence L-DOPA|nmod|involvement involvement|nmod|END_ENTITY	Immunohistochemical evidence that central serotonin neurons produce dopamine from exogenous L-DOPA in the rat , with reference to the involvement of aromatic L-amino_acid_decarboxylase .
7913379	0	dopamine	91,99	L-amino_acid_decarboxylase	23,49	dopamine	L-amino acid decarboxylase	MESH:D004298	24311(Tax:10116)	Chemical	Gene	agonists|amod|START_ENTITY effects|nmod|agonists Regulation|dep|effects Regulation|nmod|END_ENTITY	Regulation of aromatic L-amino_acid_decarboxylase in rat striatal synaptosomes : effects of dopamine receptor agonists and antagonists .
8104805	0	dopamine	97,105	L-amino_acid_decarboxylase	32,58	dopamine	L-amino acid decarboxylase	MESH:D004298	24311(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY effects|nmod|receptors Regulation|dep|effects Regulation|nmod|END_ENTITY	Regulation of striatal aromatic L-amino_acid_decarboxylase : effects of blockade or activation of dopamine receptors .
9593857	0	dopamine	139,147	L-amino_acid_decarboxylase	82,108	dopamine	L-amino acid decarboxylase	MESH:D004298	24311(Tax:10116)	Chemical	Gene	pathway|compound|START_ENTITY effects|nmod|pathway effects|nmod|activity activity|nmod|activity activity|amod|END_ENTITY	Differential effects of NMDA and non-NMDA antagonists on the activity of aromatic L-amino_acid_decarboxylase activity in the nigrostriatal dopamine pathway of the rat .
6787110	0	dopamine	40,48	LHRH	32,36	dopamine	LHRH	MESH:D004298	2796	Chemical	Gene	infusion|amod|START_ENTITY END_ENTITY|nmod|infusion	Amplification of LH response to LHRH by dopamine infusion in eugonadal women .
22564125	0	dopamine	16,24	Lmx1a	0,5	dopamine	Lmx1a	MESH:D004298	110648(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Lmx1a regulates dopamine transporter gene expression during ES cell differentiation and mouse embryonic development .
6145128	0	dopamine	48,56	Luteinizing_hormone-releasing_hormone	0,37	dopamine	Luteinizing hormone-releasing hormone	MESH:D004298	25194(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|increases increases|amod|END_ENTITY	Luteinizing_hormone-releasing_hormone increases dopamine turnover in the lateral palisade zone of the median eminence and reduces noradrenaline turnover in the nuc .
16273081	0	dopamine	65,73	MTH1	0,4	dopamine	MTH1	MESH:D004298	17766(Tax:10090)	Chemical	Gene	neurons|amod|START_ENTITY protects|dobj|neurons protects|nsubj|END_ENTITY	MTH1 , an oxidized purine nucleoside_triphosphatase , protects the dopamine neurons from oxidative damage in nucleic acids caused by 1-methyl-4-phenyl-1 ,2,3,6 - tetrahydropyridine .
21880923	0	dopamine	34,42	Mecp2	8,13	dopamine	Mecp2	MESH:D004298	17257(Tax:10090)	Chemical	Gene	neurons|compound|START_ENTITY END_ENTITY|nmod|neurons	Loss of Mecp2 in substantia nigra dopamine neurons compromises the nigrostriatal pathway .
26478315	0	dopamine	80,88	Monoamine_oxidase_B	0,19	dopamine	Monoamine oxidase B	MESH:D004298	4129	Chemical	Gene	detection|amod|START_ENTITY fabrication|nmod|detection END_ENTITY|dobj|fabrication	Monoamine_oxidase_B layer-by-layer film fabrication and characterization toward dopamine detection .
24934288	0	dopamine	80,88	NCS-1	54,59	dopamine	NCS-1	MESH:D004298	14299(Tax:10090)	Chemical	Gene	neurons|compound|START_ENTITY END_ENTITY|nmod|neurons	Cav1 .3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra dopamine neurons .
11809121	0	dopamine	26,34	NHE3	15,19	dopamine	NHE3	MESH:D004298	24784(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|END_ENTITY	-LSB- Regulation of NHE3 by D1 dopamine receptor during development of spontaneously hypertensive rats -RSB- .
15289286	0	dopamine	68,76	NOP	4,7	dopamine	NOP	MESH:D004298	12965(Tax:10090)	Chemical	Gene	release|compound|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	The NOP -LRB- ORL1 -RRB- receptor antagonist Compound B stimulates mesolimbic dopamine release and is rewarding in mice by a non-NOP-receptor-mediated mechanism .
11959923	0	dopamine	58,66	NURR1	49,54	dopamine	NURR1	MESH:D004298	4929	Chemical	Gene	neurons|amod|START_ENTITY END_ENTITY|nmod|neurons	Decreased expression of the transcription factor NURR1 in dopamine neurons of cocaine abusers .
18832154	0	dopamine	77,85	Neuregulin-1	0,12	dopamine	Neuregulin-1	MESH:D004298	211323(Tax:10090)	Chemical	Gene	receptors|amod|START_ENTITY activation|nmod|receptors regulates|nmod|activation regulates|nsubj|END_ENTITY	Neuregulin-1 regulates LTP at CA1 hippocampal synapses through activation of dopamine D4 receptors .
2387350	0	dopamine	78,86	Neuropeptide	0,12	dopamine	Neuropeptide	MESH:D004298	379044(Tax:10116)	Chemical	Gene	neurons|compound|START_ENTITY regulated|nmod|neurons regulated|nsubjpass|expression expression|amod|END_ENTITY	Neuropeptide gene expression in brain is differentially regulated by midbrain dopamine neurons .
10658621	0	dopamine	79,87	Neurotensin	0,11	dopamine	Neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	neurons|amod|START_ENTITY rate|nmod|neurons inhibition|nmod|rate attenuates|dobj|inhibition attenuates|nsubj|END_ENTITY	Neurotensin attenuates the quinpirole-induced inhibition of the firing rate of dopamine neurons in the rat substantia nigra pars compacta and the ventral tegmental area .
12064480	0	dopamine	93,101	Neurotensin	0,11	dopamine	Neurotensin	MESH:D004298	67405(Tax:10090)	Chemical	Gene	receptors|amod|START_ENTITY activation|nmod|receptors regulates|nmod|activation regulates|nsubj|END_ENTITY	Neurotensin regulates DARPP-32 thr34 phosphorylation in neostriatal neurons by activation of dopamine D1-type receptors .
1436404	0	dopamine	45,53	Neurotensin	0,11	dopamine	Neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY extracellular|dobj|levels extracellular|nsubj|increases increases|compound|END_ENTITY	Neurotensin increases extracellular striatal dopamine levels in vivo .
1676331	0	dopamine	44,52	Neurotensin	0,11	dopamine	Neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	effects|compound|START_ENTITY autoreceptor|dobj|effects autoreceptor|nsubj|modulates modulates|compound|END_ENTITY	Neurotensin modulates autoreceptor mediated dopamine effects on midbrain dopamine cell activity .
1676331	0	dopamine	73,81	Neurotensin	0,11	dopamine	Neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	activity|compound|START_ENTITY autoreceptor|nmod|activity autoreceptor|nsubj|modulates modulates|compound|END_ENTITY	Neurotensin modulates autoreceptor mediated dopamine effects on midbrain dopamine cell activity .
1698106	0	dopamine	120,128	Neurotensin	0,11	dopamine	Neurotensin	MESH:D004298	4922	Chemical	Gene	concentrations|nmod|START_ENTITY modulate|dobj|concentrations modulate|nsubj|END_ENTITY	Neurotensin and cholecystokinin microinjected into the ventral tegmental area modulate microdialysate concentrations of dopamine and metabolites in the posterior nucleus accumbens .
17015039	0	dopamine	92,100	Neurotensin	0,11	dopamine	Neurotensin	MESH:D004298	4922	Chemical	Gene	neurons|compound|START_ENTITY delivering|nmod|neurons carrier|acl|delivering polyplex|nmod|carrier polyplex|nsubj|END_ENTITY	Neurotensin polyplex as an efficient carrier for delivering the human GDNF gene into nigral dopamine neurons of hemiparkinsonian rats .
1733422	0	dopamine	38,46	Neurotensin	0,11	dopamine	Neurotensin	MESH:D004298	67405(Tax:10090)	Chemical	Gene	release|amod|START_ENTITY stimulated|dobj|release K|acl|stimulated K|compound|END_ENTITY	Neurotensin modulates K -LRB- + -RRB- - stimulated dopamine release from the caudate-putamen but not the nucleus accumbens of mice with differential sensitivity to ethanol .
1824779	0	dopamine	38,46	Neurotensin	0,11	dopamine	Neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	agonist|amod|START_ENTITY affinity|nmod|agonist binding|nsubj|affinity decreases|xcomp|binding decreases|nsubj|END_ENTITY	Neurotensin decreases the affinity of dopamine D2 agonist binding by a G protein-independent mechanism .
1982340	0	dopamine	23,31	Neurotensin	0,11	dopamine	Neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|attenuates attenuates|compound|END_ENTITY	Neurotensin attenuates dopamine D2 agonist quinpirole-induced inhibition of midbrain dopamine neurons .
1982340	0	dopamine	85,93	Neurotensin	0,11	dopamine	Neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	neurons|compound|START_ENTITY inhibition|nmod|neurons dopamine|dobj|inhibition dopamine|nsubj|attenuates attenuates|compound|END_ENTITY	Neurotensin attenuates dopamine D2 agonist quinpirole-induced inhibition of midbrain dopamine neurons .
2046877	0	dopamine	59,67	Neurotensin	0,11	dopamine	Neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	metabolism|nmod|START_ENTITY increase|nmod|metabolism causes|dobj|increase causes|nsubj|END_ENTITY	Neurotensin causes a greater increase in the metabolism of dopamine in the accumbens than in the striatum in vivo .
20504406	0	dopamine	22,30	Neurotensin	0,11	dopamine	Neurotensin	MESH:D004298	280881(Tax:9913)	Chemical	Gene	neurotransmission|amod|START_ENTITY modulates|dobj|neurotransmission modulates|nsubj|END_ENTITY	Neurotensin modulates dopamine neurotransmission at several levels along brain dopaminergic pathways .
2139501	0	dopamine	36,44	Neurotensin	0,11	dopamine	Neurotensin	MESH:D004298	4922	Chemical	Gene	receptors|amod|START_ENTITY affinity|nmod|receptors reduces|dobj|affinity reduces|nsubj|END_ENTITY	Neurotensin reduces the affinity of dopamine D2 receptors in membranes from post mortem human caudate-putamen .
22884466	0	dopamine	84,92	Neurotensin	0,11	dopamine	Neurotensin	MESH:D004298	67405(Tax:10090)	Chemical	Gene	neurons|compound|START_ENTITY inhibits|nmod|neurons inhibits|nsubj|END_ENTITY	Neurotensin inhibits glutamate-mediated synaptic inputs onto ventral tegmental area dopamine neurons through the release of the endocannabinoid 2-AG .
2313290	0	dopamine	23,31	Neurotensin	0,11	dopamine	Neurotensin	MESH:D004298	4922	Chemical	Gene	binding|xcomp|START_ENTITY binding|nsubj|END_ENTITY	Neurotensin binding to dopamine .
2525310	0	dopamine	53,61	Neurotensin	0,11	dopamine	Neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY characteristics|nmod|receptors modulates|dobj|characteristics modulates|nsubj|END_ENTITY	Neurotensin modulates the binding characteristics of dopamine D2 receptors in rat striatal membranes also following treatment with toluene .
2549437	0	dopamine	41,49	Neurotensin	0,11	dopamine	Neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	neurons|compound|START_ENTITY serum|nsubj|neurons activates|ccomp|serum activates|nsubj|END_ENTITY	Neurotensin activates tuberoinfundibular dopamine neurons and increases serum corticosterone concentrations in the rat .
26180119	0	dopamine	26,34	Neurotensin	0,11	dopamine	Neurotensin	MESH:D004298	67405(Tax:10090)	Chemical	Gene	inhibition|amod|START_ENTITY inhibits|dobj|inhibition inhibits|nsubj|END_ENTITY	Neurotensin inhibits both dopamine and GABA mediated inhibition of ventral tegmental area dopamine neurons .
26180119	0	dopamine	90,98	Neurotensin	0,11	dopamine	Neurotensin	MESH:D004298	67405(Tax:10090)	Chemical	Gene	neurons|compound|START_ENTITY inhibition|nmod|neurons inhibits|dobj|inhibition inhibits|nsubj|END_ENTITY	Neurotensin inhibits both dopamine and GABA mediated inhibition of ventral tegmental area dopamine neurons .
2819469	0	dopamine	58,66	Neurotensin	0,11	dopamine	Neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY inhibition|nmod|release counteracts|dobj|inhibition counteracts|nsubj|END_ENTITY	Neurotensin counteracts apomorphine-induced inhibition of dopamine release as studied by microdialysis in rat neostriatum .
3368012	0	dopamine	41,49	Neurotensin	0,11	dopamine	Neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY effects|nmod|release effects|compound|END_ENTITY	Neurotensin effects on evoked release of dopamine in slices from striatum , nucleus accumbens and prefrontal cortex in rat .
3386412	0	dopamine	39,47	Neurotensin	0,11	dopamine	Neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY potentiates|dobj|release potentiates|nsubj|END_ENTITY	Neurotensin potentiates the endogenous dopamine release from striatal synaptosomes of rat .
3713871	0	dopamine	22,30	Neurotensin	0,11	dopamine	Neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY effect|nmod|release effect|compound|END_ENTITY	Neurotensin effect on dopamine release and calcium transport in rat striatum : interactions with diphenylalkylamine_calcium antagonists .
4027584	0	dopamine	41,49	Neurotensin	0,11	dopamine	Neurotensin	MESH:D004298	4922	Chemical	Gene	neurones|compound|START_ENTITY depolarizes|dobj|neurones depolarizes|nsubj|END_ENTITY	Neurotensin depolarizes substantia nigra dopamine neurones .
6462447	0	dopamine	59,67	Neurotensin	0,11	dopamine	Neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY dissociation|nmod|release perfusion|dep|dissociation perfusion|compound|END_ENTITY	Neurotensin perfusion of rat hypothalamus : dissociation of dopamine release from body temperature change .
6626967	0	dopamine	24,32	Neurotensin	0,11	dopamine	Neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY facilitates|dobj|release facilitates|nsubj|END_ENTITY	Neurotensin facilitates dopamine release in vitro from rat striatal slices .
6628546	0	dopamine	68,76	Neurotensin	0,11	dopamine	Neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY potentiates|dobj|release potentiates|nsubj|END_ENTITY	Neurotensin potentiates the potassium-induced release of endogenous dopamine from rat striatal slices .
8422898	0	dopamine	68,76	Neurotensin	0,11	dopamine	Neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|control control|amod|END_ENTITY	Neurotensin and cholecystokinin_octapeptide control synergistically dopamine release and dopamine D2 receptor affinity in rat neostriatum .
8486330	0	dopamine	95,103	Neurotensin	0,11	dopamine	Neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY modulates|dobj|release modulates|nsubj|END_ENTITY	Neurotensin modulates differently potassium , veratridine and 4-aminopyridine-evoked release of dopamine in rat striatal slices .
8748677	0	dopamine	60,68	Neurotensin	0,11	dopamine	Neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY regulate|dobj|receptors regulate|nsubj|peptides peptides|compound|END_ENTITY	Neurotensin peptides antagonistically regulate postsynaptic dopamine D2 receptors in rat nucleus accumbens : a receptor binding and microdialysis study .
18772316	0	dopamine	16,24	Noggin	0,6	dopamine	Noggin	MESH:D004298	9241	Chemical	Gene	production|amod|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	Noggin enhances dopamine neuron production from human embryonic stem cells and improves behavioral outcome after transplantation into Parkinsonian rats .
9593986	0	dopamine	17,25	PACAP	0,5	dopamine	PACAP	MESH:D004298	443337(Tax:9940)	Chemical	Gene	activity|amod|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	PACAP stimulates dopamine neuronal activity in the medial basal hypothalamus and inhibits prolactin .
7824182	0	dopamine	17,25	PEC-60	0,6	dopamine	PEC-60	MESH:D004298	408233(Tax:10116)	Chemical	Gene	increases|dobj|START_ENTITY increases|nsubj|END_ENTITY	PEC-60 increases dopamine but not GABA release in the dorsolateral neostriatum of the halothane anaesthetized rat .
8852813	0	dopamine	63,71	PEC-60	46,52	dopamine	PEC-60	MESH:D004298	408233(Tax:10116)	Chemical	Gene	agonist|amod|START_ENTITY increases|dobj|agonist increases|nsubj|inhibitor inhibitor|amod|END_ENTITY	The secretory trypsin inhibitor like-peptide , PEC-60 increases dopamine D2 receptor agonist induced inhibition of GABA release in the dorsolateral neostriatum of the awake freely moving rat .
25853296	0	dopamine	26,34	PGC-1a	0,6	dopamine	PGC-1a	MESH:D004298	19017(Tax:10090)	Chemical	Gene	neurons|compound|START_ENTITY activity|nmod|neurons activity|amod|END_ENTITY	PGC-1a activity in nigral dopamine neurons determines vulnerability to a-synuclein .
19750226	0	dopamine	30,38	PTEN	22,26	dopamine	PTEN	MESH:D004298	19211(Tax:10090)	Chemical	Gene	neurons|amod|START_ENTITY END_ENTITY|nmod|neurons	Selective deletion of PTEN in dopamine neurons leads to trophic effects and adaptation of striatal medium spiny projecting neurons .
26232589	0	dopamine	64,72	PTEN	21,25	dopamine	PTEN	MESH:D004298	50557(Tax:10116)	Chemical	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	The tumor suppressor PTEN regulates motor responses to striatal dopamine in normal and Parkinsonian animals .
19563532	0	dopamine	58,66	Pals-associated_tight_junction_protein	0,38	dopamine	Pals-associated tight junction protein	MESH:D004298	10207	Chemical	Gene	links|dobj|START_ENTITY links|nsubj|END_ENTITY	Pals-associated_tight_junction_protein functionally links dopamine and angiotensin_II to the regulation of sodium transport in renal epithelial cells .
15454880	0	dopamine	9,17	Part_1	53,59	dopamine	Part 1	MESH:D004298	25859	Chemical	Gene	START_ENTITY|parataxis|-RSB- -RSB-|nsubj|considerations considerations|appos|END_ENTITY	-LSB- Central dopamine receptors : general considerations -LRB- Part_1 -RRB- -RSB- .
19780901	0	dopamine	114,122	Pitx3	84,89	dopamine	Pitx3	MESH:D004298	18742(Tax:10090)	Chemical	Gene	neurons|compound|START_ENTITY END_ENTITY|nmod|neurons	Vesicular_monoamine_transporter_2 and dopamine transporter are molecular targets of Pitx3 in the ventral midbrain dopamine neurons .
349418	0	dopamine	41,49	Plasma_LH_and_prolactin	69,92	dopamine	Plasma LH and prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|concentrations concentrations|amod|END_ENTITY	The effect of systemic administration of dopamine and apomorphine on Plasma_LH_and_prolactin concentrations in conscious rats .
16164646	0	dopamine	61,69	Prolactin	0,9	dopamine	Prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	system|compound|START_ENTITY interacting|nmod|system END_ENTITY|acl|interacting	Prolactin , a natriuretic hormone , interacting with the renal dopamine system .
17499646	0	dopamine	65,73	Prolactin	0,9	dopamine	Prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY coincides|nmod|activity coincides|nsubj|surge surge|compound|END_ENTITY	Prolactin secretory surge during estrus coincides with increased dopamine activity in the hypothalamus and preoptic area and is not altered by ovariectomy on proestrus .
1815141	0	dopamine	21,29	Prolactin	0,9	dopamine	Prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Prolactin stimulates dopamine release from the rat corpus striatum in the absence of extra-cellular calcium .
22674282	0	dopamine	39,47	Prolactin	0,9	dopamine	Prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	pattern|amod|START_ENTITY regulates|dobj|pattern regulates|nsubj|END_ENTITY	Prolactin regulates tuberoinfundibular dopamine neuron discharge pattern : novel feedback control mechanisms in the lactotrophic_axis .
2506942	0	dopamine	22,30	Prolactin	0,9	dopamine	Prolactin	MESH:D004298	5617	Chemical	Gene	administration|amod|START_ENTITY response|nmod|administration response|compound|END_ENTITY	Prolactin response to dopamine and valproate administration in breast_cancer patients .
3454564	0	dopamine	39,47	Prolactin	0,9	dopamine	Prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	turnover|nmod|START_ENTITY causes|dobj|turnover causes|nsubj|END_ENTITY	Prolactin causes increased turnover of dopamine in 10-day-old rat median eminence .
3931942	0	dopamine	102,110	Prolactin	0,9	dopamine	Prolactin	MESH:D004298	5617	Chemical	Gene	blockade|amod|START_ENTITY responses|nmod|blockade responses|nsubj|END_ENTITY	Prolactin and TSH responses to both domperidone and TRH in normal and hyperprolactinaemic women after dopamine synthesis blockade .
3989236	0	dopamine	50,58	Prolactin	0,9	dopamine	Prolactin	MESH:D004298	5617	Chemical	Gene	synthesis|amod|START_ENTITY response|nmod|synthesis response|compound|END_ENTITY	Prolactin and thyrotropin response to blockade of dopamine synthesis by monoiodotyrosine in subjects with postpartum and pathological hyperprolactinemia .
6642291	0	dopamine	26,34	Prolactin	0,9	dopamine	Prolactin	MESH:D004298	5617	Chemical	Gene	antagonists|amod|START_ENTITY response|nmod|antagonists response|compound|END_ENTITY	Prolactin response to the dopamine antagonists sulpiride and domperidone .
6860978	0	dopamine	160,168	Prolactin	0,9	dopamine	Prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	rates|amod|START_ENTITY increases|nmod|rates inhibits|dobj|increases increases|parataxis|inhibits increases|nsubj|END_ENTITY	Prolactin increases the activity of tuberoinfundibular and nigroneostriatal dopamine neurons : prolactin antiserum inhibits the haloperidol-induced increases in dopamine synthesis rates in median eminence and striatum of rats .
6860978	0	dopamine	76,84	Prolactin	0,9	dopamine	Prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	neurons|compound|START_ENTITY activity|nmod|neurons increases|dobj|activity increases|nsubj|END_ENTITY	Prolactin increases the activity of tuberoinfundibular and nigroneostriatal dopamine neurons : prolactin antiserum inhibits the haloperidol-induced increases in dopamine synthesis rates in median eminence and striatum of rats .
7070218	0	dopamine	44,52	Prolactin	0,9	dopamine	Prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY density|nmod|receptors increases|dobj|density increases|nsubj|END_ENTITY	Prolactin increases the density of striatal dopamine receptors in normal and hypophysectomized male rats .
7128535	0	dopamine	21,29	Prolactin	0,9	dopamine	Prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Prolactin stimulates dopamine release from male but not from female rat striatal tissue superfused in vitro .
7460842	0	dopamine	26,34	Prolactin	0,9	dopamine	Prolactin	MESH:D004298	5617	Chemical	Gene	augmentation|nmod|START_ENTITY augmentation|compound|END_ENTITY	Prolactin augmentation of dopamine and norepinephrine release from superfused medial basal hypothalamic fragments .
8593812	0	dopamine	91,99	Prolactin	0,9	dopamine	Prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	peptide|amod|START_ENTITY role|nmod|peptide expression|dep|role expression|amod|END_ENTITY	Prolactin gene expression and secretion during pregnancy and lactation in the rat : role of dopamine and vasoactive intestinal peptide .
23428510	0	dopamine	81,89	Protein_kinase_G	0,16	dopamine	Protein kinase G	MESH:D004298	5592	Chemical	Gene	release|amod|START_ENTITY END_ENTITY|nsubj|release	Protein_kinase_G linked to dopamine D3 receptors in the dorsal striatum controls dopamine release , / \ FosB expression and locomotor activity after repeated cocaine administration .
23585124	0	dopamine	27,35	Protein_kinase_G	0,16	dopamine	Protein kinase G	MESH:D004298	5592	Chemical	Gene	release|amod|START_ENTITY END_ENTITY|nsubj|release	Protein_kinase_G regulates dopamine release , / \ FosB expression , and locomotor activity after repeated cocaine administration : involvement of dopamine D2 receptors .
12818179	0	dopamine	15,23	RGS9	0,4	dopamine	RGS9	MESH:D004298	29481(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|modulates modulates|compound|END_ENTITY	RGS9 modulates dopamine signaling in the basal ganglia .
15189762	0	dopamine	40,48	Resistin	0,8	dopamine	Resistin	MESH:D004298	56729	Chemical	Gene	release|amod|START_ENTITY inhibits|dobj|release inhibits|nsubj|END_ENTITY	Resistin , but not adiponectin , inhibits dopamine and norepinephrine release in the hypothalamus .
11739616	0	dopamine	106,114	SLC6A3	31,37	dopamine	SLC6A3	MESH:D004298	6531	Chemical	Gene	neurons|amod|START_ENTITY transcription|nmod|neurons enhances|dobj|transcription repeats|ccomp|enhances repeats|nsubj|gene gene|appos|END_ENTITY	The dopamine_transporter gene -LRB- SLC6A3 -RRB- variable number of tandem repeats domain enhances transcription in dopamine neurons .
16526040	0	dopamine	14,22	SLC6A3	56,62	dopamine	SLC6A3	MESH:D004298	6531	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	The effect of dopamine D2 , D5 receptor and transporter -LRB- SLC6A3 -RRB- polymorphisms on the cue-elicited heroin craving in Chinese .
26831905	0	dopamine	22,30	SLC6A3	43,49	dopamine	SLC6A3	MESH:D004298	6531	Chemical	Gene	transporter|amod|START_ENTITY Identification|nmod|transporter END_ENTITY|nsubj|Identification	Identification of the dopamine transporter SLC6A3 as a biomarker for patients with renal_cell_carcinoma .
10336855	0	dopamine	28,36	SULT1A3	55,62	dopamine	SULT1A3	MESH:D004298	6818	Chemical	Gene	sulfotransferase|compound|START_ENTITY sulfotransferase|appos|END_ENTITY	Kinetic properties of human dopamine sulfotransferase -LRB- SULT1A3 -RRB- expressed in prokaryotic and eukaryotic systems : comparison with the recombinant enzyme purified from Escherichia_coli .
10608851	0	dopamine	33,41	SULT1A3	60,67	dopamine	SULT1A3	MESH:D004298	6818	Chemical	Gene	sulfotransferase|compound|START_ENTITY sulfotransferase|appos|END_ENTITY	X-ray crystal structure of human dopamine sulfotransferase , SULT1A3 .
16083857	0	dopamine	68,76	SULT1A3	44,51	dopamine	SULT1A3	MESH:D004298	6818	Chemical	Gene	complex|nmod|START_ENTITY END_ENTITY|nmod|complex	Crystal structure of human sulfotransferase SULT1A3 in complex with dopamine and 3 ' - phosphoadenosine_5 ' - phosphate .
9855620	0	dopamine	74,82	SULT1A3	101,108	dopamine	SULT1A3	MESH:D004298	6818	Chemical	Gene	sulfotransferase|compound|START_ENTITY sulfotransferase|appos|END_ENTITY	A single amino_acid , glu146 , governs the substrate specificity of a human dopamine sulfotransferase , SULT1A3 .
6130131	0	dopamine	23,31	Somatostatin	0,12	dopamine	Somatostatin	MESH:D004298	24797(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY regulates|dobj|release regulates|nsubj|END_ENTITY	Somatostatin regulates dopamine release in rat striatal slices and cat caudate nuclei .
11207940	0	dopamine	121,129	TH	89,91	dopamine	TH	MESH:D004298	25085(Tax:10116)	Chemical	Gene	concentrations|compound|START_ENTITY END_ENTITY|dobj|concentrations	Effects of chronic bromocriptine treatment on tyrosine_hydroxylase -LRB- TH -RRB- mRNA expression , TH activity and median eminence dopamine concentrations in ageing rats .
16965772	0	dopamine	32,40	TNF-alpha	101,110	dopamine	TNF-alpha	MESH:D004298	24835(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY GLC756|appos|receptor Effect|nmod|GLC756 antagonist|nsubj|Effect antagonist|nmod|release release|amod|END_ENTITY	Effect of GLC756 , a novel mixed dopamine D1 receptor antagonist and dopamine D2 receptor agonist , on TNF-alpha release in vitro from activated rat mast cells .
19271121	0	dopamine	62,70	TNF-alpha	102,111	dopamine	TNF-alpha	MESH:D004298	21926(Tax:10090)	Chemical	Gene	depletion|compound|START_ENTITY depletion|acl|modulating modulating|dobj|END_ENTITY	Lipopolysaccharide mitagates methamphetamine-induced striatal dopamine depletion via modulating local TNF-alpha and dopamine_transporter expression .
20504569	0	dopamine	17,25	TRH	37,40	dopamine	TRH	MESH:D004298	25569(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY release|nmod|END_ENTITY	In vivo striatal dopamine release by TRH analog YM-14673 is blocked by M1 muscarinic receptor antagonist .
27006143	0	dopamine	55,63	TRH	0,3	dopamine	TRH	MESH:D004298	25569(Tax:10116)	Chemical	Gene	releases|dobj|START_ENTITY releases|nsubj|END_ENTITY	TRH injected into the nucleus accumbens shell releases dopamine and reduces feeding motivation in rats .
18674612	0	dopamine	41,49	TRP-2	0,5	dopamine	TRP-2	MESH:D004298	1638	Chemical	Gene	toxicity|amod|START_ENTITY protects|nmod|toxicity protects|nsubj|expression expression|compound|END_ENTITY	TRP-2 expression protects HEK cells from dopamine - and hydroquinone-induced toxicity .
119692	0	dopamine	70,78	Thyrotropin-releasing_hormone	1,30	dopamine	Thyrotropin-releasing hormone	MESH:D004298	25569(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY mechanism|nmod|release END_ENTITY|dep|mechanism	-LSB- Thyrotropin-releasing_hormone -LRB- TRH -RRB- : action mechanism of an enhanced dopamine release from rat striatal slices -LRB- author 's transl -RRB- -RSB- .
119887	0	dopamine	60,68	Thyrotropin-releasing_hormone	0,29	dopamine	Thyrotropin-releasing hormone	MESH:D004298	25569(Tax:10116)	Chemical	Gene	system|amod|START_ENTITY END_ENTITY|dep|system	Thyrotropin-releasing_hormone : hyperactivity and mesolimbic dopamine system in rats .
231554	0	dopamine	53,61	Thyrotropin-releasing_hormone	1,30	dopamine	Thyrotropin-releasing hormone	MESH:D004298	22044(Tax:10090)	Chemical	Gene	dependent|amod|START_ENTITY behavior|amod|dependent Enhancement|nmod|behavior END_ENTITY|dep|Enhancement	-LSB- Thyrotropin-releasing_hormone -LRB- TRH -RRB- : Enhancement of dopamine dependent circling behavior and its own circling-inducing effect in unilateral striatal lesioned animals -LRB- author 's transl -RRB- -RSB- .
18990365	0	dopamine	47,55	Tropomyosin-related_kinase_B	0,28	dopamine	Tropomyosin-related kinase B	MESH:D004298	25054(Tax:10116)	Chemical	Gene	system|compound|START_ENTITY END_ENTITY|nmod|system	Tropomyosin-related_kinase_B in the mesolimbic dopamine system : region-specific effects on cocaine reward .
8915597	0	dopamine	56,64	Tyrosinase	0,10	dopamine	Tyrosinase	MESH:D004298	7299	Chemical	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	Tyrosinase enhances the covalent modification of DNA by dopamine .
21176768	0	dopamine	39,47	Tyrosine_hydroxylase	0,20	dopamine	Tyrosine hydroxylase	MESH:D004298	7054	Chemical	Gene	synthesis|amod|START_ENTITY END_ENTITY|nmod|synthesis	Tyrosine_hydroxylase and regulation of dopamine synthesis .
2882825	0	dopamine	98,106	Tyrosine_hydroxylase	0,20	dopamine	Tyrosine hydroxylase	MESH:D004298	25085(Tax:10116)	Chemical	Gene	system|compound|START_ENTITY immunochemistry|nmod|system immunochemistry|amod|END_ENTITY	Tyrosine_hydroxylase immunochemistry and quantitative light microscopic studies of the mesolimbic dopamine system in rat brain : effects of chronic methamphetamine administration .
20018672	0	dopamine	10,18	VGLUT2	0,6	dopamine	VGLUT2	MESH:D004298	140919(Tax:10090)	Chemical	Gene	neurons|amod|START_ENTITY END_ENTITY|nmod|neurons	VGLUT2 in dopamine neurons is required for psychostimulant-induced behavioral activation .
10657034	0	dopamine	41,49	VMAT2	105,110	dopamine	VMAT2	MESH:D004298	214084(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Rapid and differential losses of in vivo dopamine transporter -LRB- DAT -RRB- and vesicular monoamine transporter -LRB- VMAT2 -RRB- radioligand binding in MPTP-treated mice .
12112404	0	dopamine	29,37	VMAT2	106,111	dopamine	VMAT2	MESH:D004298	6571	Chemical	Gene	D2-receptors|amod|START_ENTITY targeting|nmod|D2-receptors monoamine|nsubj|targeting monoamine|dobj|2 2|appos|END_ENTITY	Region-specific targeting of dopamine D2-receptors and somatodendritic vesicular monoamine transporter 2 -LRB- VMAT2 -RRB- within ventral tegmental area subdivisions .
12716422	0	dopamine	32,40	VMAT2	103,108	dopamine	VMAT2	MESH:D004298	214084(Tax:10090)	Chemical	Gene	control|nmod|START_ENTITY neurotransmission|nsubj|control neurotransmission|dobj|mice mice|appos|END_ENTITY	Presynaptic control of striatal dopamine neurotransmission in adult vesicular_monoamine_transporter_2 -LRB- VMAT2 -RRB- mutant mice .
17664021	0	dopamine	70,78	VMAT2	55,60	dopamine	VMAT2	MESH:D004298	214084(Tax:10090)	Chemical	Gene	activity|amod|START_ENTITY reduces|dobj|activity reduces|nsubj|deletion deletion|nmod|vesicular_monoamine_transporter-2 vesicular_monoamine_transporter-2|appos|END_ENTITY	Genetic deletion of vesicular_monoamine_transporter-2 -LRB- VMAT2 -RRB- reduces dopamine transporter activity in mesencephalic neurons in primary culture .
18720517	0	dopamine	127,135	VMAT2	76,81	dopamine	VMAT2	MESH:D004298	25549(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY changes|nmod|concentration sensitive|nmod|changes sensitive|nsubj|binding binding|compound|END_ENTITY	Dopamine modulating drugs influence striatal -LRB- + -RRB- - -LSB- 11C -RSB- DTBZ binding in rats : VMAT2 binding is sensitive to changes in vesicular dopamine concentration .
18815269	0	dopamine	124,132	VMAT2	109,114	dopamine	VMAT2	MESH:D004298	6571	Chemical	Gene	biomarker|amod|START_ENTITY biomarker|nsubj|END_ENTITY	Increased vesicular monoamine transporter binding during early abstinence in human methamphetamine users : Is VMAT2 a stable dopamine neuron biomarker ?
23875705	0	dopamine	87,95	VMAT2	11,16	dopamine	VMAT2	MESH:D004298	25549(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY changes|nmod|release lobeline|nmod|changes inhibitors|dobj|lobeline inhibitors|nsubj|Effects Effects|nmod|END_ENTITY	Effects of VMAT2 inhibitors lobeline and GZ-793A on methamphetamine-induced changes in dopamine release , metabolism and synthesis in vivo .
25220836	0	dopamine	46,54	VMAT2	0,5	dopamine	VMAT2	MESH:D004298	6571	Chemical	Gene	vesicle|amod|START_ENTITY harnessing|dobj|vesicle disease|parataxis|harnessing disease|nmod:poss|END_ENTITY	VMAT2 and Parkinson 's _ disease : harnessing the dopamine vesicle .
17244889	0	dopamine	43,51	Vesicular_monoamine_transporter_1	0,33	dopamine	Vesicular monoamine transporter 1	MESH:D004298	25693(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY mediates|dobj|secretion mediates|nsubj|END_ENTITY	Vesicular_monoamine_transporter_1 mediates dopamine secretion in rat proximal tubular cells .
23444360	0	dopamine	49,57	Wnt1	32,36	dopamine	Wnt1	MESH:D004298	7471	Chemical	Gene	START_ENTITY|nsubj|requirement requirement|nmod|END_ENTITY	Dynamic temporal requirement of Wnt1 in midbrain dopamine neuron development .
11447325	0	dopamine	73,81	alpha-MSH	26,35	dopamine	alpha-MSH	MESH:D004298	24664(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|release release|amod|END_ENTITY	The MC4 receptor mediates alpha-MSH induced release of nucleus accumbens dopamine .
1649748	0	dopamine	43,51	alpha-melanocyte-stimulating_hormone	92,128	dopamine	alpha-melanocyte-stimulating hormone	MESH:D004298	24664(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|role role|nmod|END_ENTITY	Suckling unmasks the stimulatory effect of dopamine on prolactin release : possible role for alpha-melanocyte-stimulating_hormone as a mammotrope responsiveness factor .
3100385	2	dopamine	146,154	alpha-melanocyte-stimulating_hormone	192,228	dopamine	alpha-melanocyte-stimulating hormone	MESH:D004298	5443	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|secretion secretion|amod|END_ENTITY	Interaction between dopamine and thyrotropin-releasing_hormone on alpha-melanocyte-stimulating_hormone secretion .
12684441	0	dopamine	61,69	alpha-synuclein	42,57	dopamine	alpha-synuclein	MESH:D004298	6622	Chemical	Gene	neurons|amod|START_ENTITY END_ENTITY|nmod|neurons	Cocaine abusers have an overexpression of alpha-synuclein in dopamine neurons .
17169335	0	dopamine	112,120	aminopeptidase_N	55,71	dopamine	aminopeptidase N	MESH:D004298	81641(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY END_ENTITY|nmod|release	Involvement of insulin-regulated_aminopeptidase and/or aminopeptidase_N in the angiotensin_IV-induced effect on dopamine release in the striatum of the rat .
15312180	0	dopamine	67,75	angiotensin_II	14,28	dopamine	angiotensin II	MESH:D004298	24179(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY effect|nmod|release required|nmod|effect required|nsubjpass|Metabolism Metabolism|nmod|END_ENTITY	Metabolism of angiotensin_II is required for its in vivo effect on dopamine release in the striatum of the rat .
15699451	0	dopamine	44,52	angiotensin_II	15,29	dopamine	angiotensin II	MESH:D004298	24179(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Interaction of angiotensin_II type 1 and D5 dopamine receptors in renal proximal tubule cells .
1839152	0	dopamine	42,50	angiotensin_II	56,70	dopamine	angiotensin II	MESH:D004298	24179(Tax:10116)	Chemical	Gene	interaction|nmod|START_ENTITY involved|nmod|interaction involved|nmod|END_ENTITY	Mechanisms involved in the interaction of dopamine with angiotensin_II on aldosterone secretion in isolated and cultured rat adrenal glomerulosa cells .
20389130	0	dopamine	35,43	angiotensin_II	11,25	dopamine	angiotensin II	MESH:D004298	24179(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	Effects of angiotensin_II on renal dopamine metabolism : synthesis , release , catabolism and turnover .
25496286	0	dopamine	24,32	angiotensin_II	120,134	dopamine	angiotensin II	MESH:D004298	183	Chemical	Gene	START_ENTITY|nmod|migration migration|nmod|cells cells|acl|induced induced|nmod|effect effect|nmod|END_ENTITY	Inhibitory effect of D3 dopamine receptor on migration of vascular smooth muscle cells induced by synergistic effect of angiotensin_II and aldosterone .
25645462	0	dopamine	46,54	angiotensin_II	8,22	dopamine	angiotensin II	MESH:D004298	183	Chemical	Gene	neurons|amod|START_ENTITY expression|nmod|neurons expression|amod|END_ENTITY	Loss of angiotensin_II receptor expression in dopamine neurons in Parkinson 's _ disease correlates with pathological progression and is accompanied by increases in Nox4 - _ and_8-OH_guanosine-related nucleic acid oxidation and caspase-3 activation .
3149773	0	dopamine	12,20	angiotensin_II	51,65	dopamine	angiotensin II	MESH:D004298	24179(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of dopamine in the facilitatory effect of angiotensin_II on impaired learning in rats chronically treated with ethanol .
6785812	0	dopamine	41,49	angiotensin_II	74,88	dopamine	angiotensin II	MESH:D004298	24179(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|thirst thirst|amod|END_ENTITY	Effects of specific dopamine lesions and dopamine receptor sensitivity on angiotensin_II - and carbachol-induced thirst in rats .
7049683	0	dopamine	14,22	angiotensin_II	91,105	dopamine	angiotensin II	MESH:D004298	183	Chemical	Gene	antagonist|amod|START_ENTITY Reversal|nmod|antagonist Reversal|nmod|infusion infusion|amod|END_ENTITY	Reversal by a dopamine antagonist of saline-induced attenuation of aldosterone response to angiotensin_II infusion in man .
7514480	0	dopamine	29,37	angiotensin_II	11,25	dopamine	angiotensin II	MESH:D004298	24179(Tax:10116)	Chemical	Gene	turnover|compound|START_ENTITY END_ENTITY|nmod|turnover	Effects of angiotensin_II on dopamine and serotonin turnover in the striatum of conscious rats .
8381932	0	dopamine	8,16	angiotensin_II	29,43	dopamine	angiotensin II	MESH:D004298	183	Chemical	Gene	response|amod|START_ENTITY response|nmod|END_ENTITY	Urinary dopamine response to angiotensin_II is not abnormal in type 1 -LRB- insulin-dependent -RRB- diabetes_mellitus .
8726689	0	dopamine	44,52	angiotensin_II	16,30	dopamine	angiotensin II	MESH:D004298	24179(Tax:10116)	Chemical	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of angiotensin_II with central dopamine .
8735646	0	dopamine	47,55	angiotensin_II	11,25	dopamine	angiotensin II	MESH:D004298	24179(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY modulate|dobj|release Ability|acl|modulate Ability|nmod|END_ENTITY	Ability of angiotensin_II to modulate striatal dopamine release via the AT1 receptor in vitro and in vivo .
1604042	0	dopamine	11,19	arginine_vasopressin	43,63	dopamine	arginine vasopressin	MESH:D004298	24221(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of dopamine on renal receptors for arginine_vasopressin .
10889539	0	dopamine	29,37	atrial_natriuretic_factor	71,96	dopamine	atrial natriuretic factor	MESH:D004298	24602(Tax:10116)	Chemical	Gene	modulation|nmod|START_ENTITY mediated|nsubj|modulation mediated|nmod|neurons neurons|compound|END_ENTITY	Glucocorticoid modulation of dopamine mediated effects on hypothalamic atrial_natriuretic_factor neurons .
1832595	0	dopamine	26,34	atrial_natriuretic_factor	78,103	dopamine	atrial natriuretic factor	MESH:D004298	24602(Tax:10116)	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|effects effects|nmod|END_ENTITY	Involvement of endogenous dopamine and DA-1 receptors in the renal effects of atrial_natriuretic_factor in rats .
7835293	0	dopamine	21,29	atrial_natriuretic_factor	60,85	dopamine	atrial natriuretic factor	MESH:D004298	24602(Tax:10116)	Chemical	Gene	stimulation|compound|START_ENTITY stimulation|nmod|END_ENTITY	D1 receptors mediate dopamine stimulation of immunoreactive atrial_natriuretic_factor -LRB- ANF -RRB- release and pro-ANF messenger ribonucleic acid expression of rat hypothalamic neurons in culture .
2856726	0	dopamine	77,85	atrial_natriuretic_peptide	20,46	dopamine	atrial natriuretic peptide	MESH:D004298	4878	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|END_ENTITY	The effect of human atrial_natriuretic_peptide on urinary sodium and urinary dopamine excretion in man .
10576546	0	dopamine	14,22	basic_fibroblast_growth_factor	33,63	dopamine	basic fibroblast growth factor	MESH:D004298	54250(Tax:10116)	Chemical	Gene	Regulation|nmod|START_ENTITY uptake|nsubj|Regulation uptake|nmod|END_ENTITY	Regulation of dopamine uptake by basic_fibroblast_growth_factor and epidermal_growth_factor in cultured rat astrocytes .
187956	0	dopamine	47,55	beta-Endorphin	0,14	dopamine	beta-Endorphin	MESH:D004298	5443	Chemical	Gene	release|compound|START_ENTITY END_ENTITY|nmod|release	beta-Endorphin in vitro inhibition of striatal dopamine release .
19439492	0	dopamine	80,88	beta-catenin	18,30	dopamine	beta-catenin	MESH:D004298	1499	Chemical	Gene	neurons|amod|START_ENTITY neurons|amod|END_ENTITY	Multiple roles of beta-catenin in controlling the neurogenic niche for midbrain dopamine neurons .
2280212	0	dopamine	135,143	beta-endorphin	86,100	dopamine	beta-endorphin	MESH:D004298	5443	Chemical	Gene	opioids|amod|START_ENTITY role|nmod|opioids Regulation|dep|role Regulation|nmod|cycle cycle|nmod|concentrations concentrations|nmod|END_ENTITY	Regulation of the photoperiod-induced cycle in the peripheral blood concentrations of beta-endorphin and prolactin in the ram : role of dopamine and endogenous opioids .
2758326	0	dopamine	15,23	beta-endorphin	63,77	dopamine	beta-endorphin	MESH:D004298	5443	Chemical	Gene	output|amod|START_ENTITY Stimulation|nmod|output Stimulation|nmod|cells cells|nmod|END_ENTITY	Stimulation of dopamine output from adrenal medullary cells by beta-endorphin and its C-terminal tetrapeptide -LRB- MPF -RRB- .
2951610	0	dopamine	91,99	beta-endorphin	52,66	dopamine	beta-endorphin	MESH:D004298	5443	Chemical	Gene	regulation|nmod|START_ENTITY Neurosecretion|dep|regulation Neurosecretion|nmod|END_ENTITY	Neurosecretion of human hypothalamic immunoreactive beta-endorphin : in vitro regulation by dopamine .
743624	0	dopamine	21,29	beta-endorphin	100,114	dopamine	beta-endorphin	MESH:D004298	5443	Chemical	Gene	Alterations|nmod|START_ENTITY metabolism|nsubj|Alterations metabolism|nmod|END_ENTITY	Alterations in brain dopamine and serotonin metabolism during the development of tolerance to human beta-endorphin in rats .
7557642	0	dopamine	13,21	beta-endorphin	68,82	dopamine	beta-endorphin	MESH:D004298	5443	Chemical	Gene	antagonist|amod|START_ENTITY Effects|nmod|antagonist Effects|nmod|release release|nmod|END_ENTITY	Effects of a dopamine antagonist -LRB- metoclopramide -RRB- on the release of beta-endorphin , ACTH and cortisol in hyperprolactinemic-amenorrheic_women .
8847953	0	dopamine	91,99	beta-endorphin	24,38	dopamine	beta-endorphin	MESH:D004298	5443	Chemical	Gene	responsiveness|nmod|START_ENTITY Regulation|dep|responsiveness Regulation|nmod|secretion secretion|amod|END_ENTITY	Regulation of pituitary beta-endorphin secretion in aging rats : in vitro responsiveness to dopamine .
905630	0	dopamine	37,45	beta-endorphin	10,24	dopamine	beta-endorphin	MESH:D004298	5443	Chemical	Gene	metabolism|compound|START_ENTITY Effect|nmod|metabolism Effect|nmod|END_ENTITY	Effect of beta-endorphin on striatal dopamine metabolism .
11334998	0	dopamine	39,47	brain-derived_neurotrophic_factor	169,202	dopamine	brain-derived neurotrophic factor	MESH:D004298	627	Chemical	Gene	formation|nmod|START_ENTITY induction|nmod|formation induction|nmod|rat rat|nmod|END_ENTITY	Parallel induction of the formation of dopamine and its metabolites with induction of tyrosine_hydroxylase expression in foetal rat and human cerebral cortical cells by brain-derived_neurotrophic_factor and glial-cell_derived_neurotrophic_factor .
12556415	0	dopamine	63,71	brain-derived_neurotrophic_factor	19,52	dopamine	brain-derived neurotrophic factor	MESH:D004298	100356949(Tax:9986)	Chemical	Gene	START_ENTITY|nsubj|increases increases|amod|END_ENTITY	Mechanism by which brain-derived_neurotrophic_factor increases dopamine release from the rabbit retina .
12574402	0	dopamine	99,107	brain-derived_neurotrophic_factor	28,61	dopamine	brain-derived neurotrophic factor	MESH:D004298	24225(Tax:10116)	Chemical	Gene	system|compound|START_ENTITY levels|nmod|system levels|amod|END_ENTITY	Time-dependent increases in brain-derived_neurotrophic_factor protein levels within the mesolimbic dopamine system after withdrawal from cocaine : implications for incubation of cocaine craving .
12668147	0	dopamine	195,203	brain-derived_neurotrophic_factor	48,81	dopamine	brain-derived neurotrophic factor	MESH:D004298	24225(Tax:10116)	Chemical	Gene	survival|nmod|START_ENTITY Interactions|nmod|survival Interactions|nmod|END_ENTITY	Interactions of cyclic_adenosine_monophosphate , brain-derived_neurotrophic_factor , and glial_cell_line-derived_neurotrophic_factor treatment on the survival and growth of postnatal mesencephalic dopamine neurons in vitro .
12738784	0	dopamine	95,103	brain-derived_neurotrophic_factor	40,73	dopamine	brain-derived neurotrophic factor	MESH:D004298	627	Chemical	Gene	III|nmod|START_ENTITY III|nsubj|activation activation|nmod|promoter promoter|amod|END_ENTITY	Transcriptional activation of the human brain-derived_neurotrophic_factor gene promoter III by dopamine signaling in NT2/N neurons .
12809697	0	dopamine	67,75	brain-derived_neurotrophic_factor	15,48	dopamine	brain-derived neurotrophic factor	MESH:D004298	24225(Tax:10116)	Chemical	Gene	behaviors|amod|START_ENTITY release|nmod|behaviors END_ENTITY|nmod|release	Implication of brain-derived_neurotrophic_factor in the release of dopamine and dopamine-related behaviors induced by methamphetamine .
16390493	0	dopamine	114,122	brain-derived_neurotrophic_factor	13,46	dopamine	brain-derived neurotrophic factor	MESH:D004298	24225(Tax:10116)	Chemical	Gene	requires|dobj|START_ENTITY requires|nsubj|Secretion Secretion|nmod|END_ENTITY	Secretion of brain-derived_neurotrophic_factor from PC12 cells in response to oxidative stress requires autocrine dopamine signaling .
16890350	0	dopamine	115,123	brain-derived_neurotrophic_factor	66,99	dopamine	brain-derived neurotrophic factor	MESH:D004298	24225(Tax:10116)	Chemical	Gene	depletion|compound|START_ENTITY depletion|amod|END_ENTITY	CGP_56999A , a GABA -LRB- B -RRB- receptor antagonist , enhances expression of brain-derived_neurotrophic_factor and attenuates dopamine depletion in the rat corpus striatum following a 6-hydroxydopamine lesion of the nigrostriatal pathway .
21163332	0	dopamine	43,51	brain-derived_neurotrophic_factor	67,100	dopamine	brain-derived neurotrophic factor	MESH:D004298	12064(Tax:10090)	Chemical	Gene	increases|nmod|START_ENTITY blunted|nsubjpass|increases blunted|nmod|mice mice|amod|END_ENTITY	Ethanol-induced increases in extracellular dopamine are blunted in brain-derived_neurotrophic_factor heterozygous mice .
21990022	0	dopamine	101,109	brain-derived_neurotrophic_factor	42,75	dopamine	brain-derived neurotrophic factor	MESH:D004298	24225(Tax:10116)	Chemical	Gene	system|compound|START_ENTITY produces|nmod|system produces|dobj|END_ENTITY	Gestational IV nicotine produces elevated brain-derived_neurotrophic_factor in the mesocorticolimbic dopamine system of adolescent rat offspring .
24517838	0	dopamine	21,29	brain-derived_neurotrophic_factor	75,108	dopamine	brain-derived neurotrophic factor	MESH:D004298	12064(Tax:10090)	Chemical	Gene	release|compound|START_ENTITY leads|nsubj|release leads|nmod|hyperdopaminergia hyperdopaminergia|nmod|mice mice|amod|END_ENTITY	Potentiated striatal dopamine release leads to hyperdopaminergia in female brain-derived_neurotrophic_factor heterozygous mice .
24908088	0	dopamine	36,44	brain-derived_neurotrophic_factor	74,107	dopamine	brain-derived neurotrophic factor	MESH:D004298	12064(Tax:10090)	Chemical	Gene	neurons|amod|START_ENTITY vibration_training|nmod|neurons Protection|acl|vibration_training Protection|nmod|END_ENTITY	Protection of vibration_training on dopamine neurons and up-regulation of brain-derived_neurotrophic_factor in a MPTP Mouse Model of Parkinson 's _ disease .
26198255	0	dopamine	90,98	brain-derived_neurotrophic_factor	30,63	dopamine	Brain-Derived Neurotrophic Factor	MESH:D004298	24225(Tax:10116)	Chemical	Gene	neurons|compound|START_ENTITY delivery|nmod|neurons delivery|amod|END_ENTITY	Neurotensin-polyplex-mediated brain-derived_neurotrophic_factor gene delivery into nigral dopamine neurons prevents nigrostriatal_degeneration in a rat model of early Parkinson 's _ disease .
26198255	0	dopamine	90,98	brain-derived_neurotrophic_factor	30,63	dopamine	Brain-Derived Neurotrophic Factor	MESH:D004298	24225(Tax:10116)	Chemical	Gene	neurons|compound|START_ENTITY delivery|nmod|neurons delivery|amod|END_ENTITY	Neurotensin-polyplex-mediated brain-derived_neurotrophic_factor gene delivery into nigral dopamine neurons prevents nigrostriatal_degeneration in a rat model of early Parkinson 's _ disease .
7519657	0	dopamine	144,152	brain-derived_neurotrophic_factor	12,45	dopamine	brain-derived neurotrophic factor	MESH:D004298	24225(Tax:10116)	Chemical	Gene	lesions|compound|START_ENTITY associated|nmod|lesions associated|nsubj|Efficacy Efficacy|nmod|END_ENTITY	Efficacy of brain-derived_neurotrophic_factor and neurotrophin-3 on neurochemical and behavioral deficits associated with partial nigrostriatal dopamine lesions .
7523178	0	dopamine	107,115	brain-derived_neurotrophic_factor	27,60	dopamine	brain-derived neurotrophic factor	MESH:D004298	24225(Tax:10116)	Chemical	Gene	transport|nmod|START_ENTITY infusions|dep|transport infusions|nmod|END_ENTITY	Intrastriatal infusions of brain-derived_neurotrophic_factor : retrograde transport and colocalization with dopamine containing substantia nigra neurons in rat .
10199616	0	dopamine	29,37	c-fos	55,60	dopamine	c-fos	MESH:D004298	2353	Chemical	Gene	modulation|nmod|START_ENTITY modulation|nmod|expression expression|amod|END_ENTITY	Opposite tonic modulation of dopamine and adenosine on c-fos gene expression in striatopallidal neurons .
1882334	0	dopamine	65,73	cholecystokinin	24,39	dopamine	cholecystokinin	MESH:D004298	25298(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|selectivity selectivity|nmod|effects effects|compound|END_ENTITY	Receptor selectivity of cholecystokinin effects on mesoaccumbens dopamine neurons .
1957561	0	dopamine	114,122	cholecystokinin	93,108	dopamine	cholecystokinin	MESH:D004298	397468(Tax:9823)	Chemical	Gene	antagonist|amod|START_ENTITY END_ENTITY|nmod|antagonist	Hormonal effects of apomorphine and cholecystokinin in pigs : modification of the response to cholecystokinin by a dopamine antagonist -LRB- metoclopramide -RRB- and a kappa opioid agonist -LRB- PD117302 -RRB- .
1978324	0	dopamine	45,53	cholecystokinin	26,41	dopamine	cholecystokinin	MESH:D004298	885	Chemical	Gene	cells|amod|START_ENTITY Analysis|nmod|cells Analysis|nmod|END_ENTITY	Analysis of expression of cholecystokinin in dopamine cells in the ventral mesencephalon of several species and in humans with schizophrenia .
2706523	0	dopamine	49,57	cholecystokinin	69,84	dopamine	cholecystokinin	MESH:D004298	12424(Tax:10090)	Chemical	Gene	release|amod|START_ENTITY suppression|nmod|release mediate|dobj|suppression mediate|nmod|END_ENTITY	Brain CCK-B_receptors mediate the suppression of dopamine release by cholecystokinin .
2743135	0	dopamine	37,45	cholecystokinin	5,20	dopamine	cholecystokinin	MESH:D004298	885	Chemical	Gene	colocalize|nmod|START_ENTITY colocalize|nsubj|END_ENTITY	Does cholecystokinin colocalize with dopamine in the human substantia nigra ?
3561887	0	dopamine	115,123	cholecystokinin	89,104	dopamine	cholecystokinin	MESH:D004298	25298(Tax:10116)	Chemical	Gene	systems|compound|START_ENTITY systems|compound|END_ENTITY	Behavioral evidence for the involvement of endogenous opioids in the interaction between cholecystokinin and brain dopamine systems .
6717857	0	dopamine	59,67	cholecystokinin	4,19	dopamine	cholecystokinin	MESH:D004298	25298(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY modulate|dobj|release modulate|nsubj|analogue analogue|compound|END_ENTITY	The cholecystokinin analogue , caerulein , does not modulate dopamine release or dopamine-induced locomotor activity in the nucleus accumbens of rat .
7126854	0	dopamine	30,38	cholecystokinin	11,26	dopamine	cholecystokinin	MESH:D004298	25298(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY END_ENTITY|nmod|metabolism	-LSB- Effect of cholecystokinin on dopamine metabolism in the rat brain -RSB- .
7173435	0	dopamine	72,80	cholecystokinin	43,58	dopamine	cholecystokinin	MESH:D004298	25298(Tax:10116)	Chemical	Gene	systems|amod|START_ENTITY inhibits|dobj|systems inhibits|nsubj|administration administration|nmod|END_ENTITY	-LSB- Intracerebroventricular administration of cholecystokinin inhibits the dopamine - and serotoninergic systems of the brain -RSB- .
9639255	0	dopamine	14,22	cholecystokinin	124,139	dopamine	cholecystokinin	MESH:D004298	25298(Tax:10116)	Chemical	Gene	accumbens|amod|START_ENTITY affected|nsubj|accumbens affected|nmod|administration administration|nmod|END_ENTITY	Extracellular dopamine in the anterior nucleus accumbens is distinctly affected by ventral tegmental area administration of cholecystokinin and apomorphine : data from in vivo voltammetry .
15784652	0	dopamine	94,102	corticotropin-releasing_factor	18,48	dopamine	corticotropin-releasing factor	MESH:D004298	1392	Chemical	Gene	release|compound|START_ENTITY inhibits|dobj|release END_ENTITY|acl:relcl|inhibits	Acute and chronic corticotropin-releasing_factor 1 receptor blockade inhibits cocaine-induced dopamine release : correlation with dopamine neuron activity .
19729048	0	dopamine	30,38	corticotropin-releasing_factor	50,80	dopamine	corticotropin-releasing factor	MESH:D004298	1392	Chemical	Gene	Regulation|nmod|START_ENTITY release|nsubj|Regulation release|nmod|END_ENTITY	Regulation of somatodendritic dopamine release by corticotropin-releasing_factor via the inhibition of voltage-operated Ca2 + channels .
2477258	0	dopamine	28,36	corticotropin-releasing_factor	50,80	dopamine	corticotropin-releasing factor	MESH:D004298	81648(Tax:10116)	Chemical	Gene	synthesis|compound|START_ENTITY synthesis|nmod|END_ENTITY	Stimulation of synaptosomal dopamine synthesis by corticotropin-releasing_factor in rat striatum : role of Ca2 + - dependent mechanisms .
2114303	0	dopamine	76,84	dopamine_D-2_receptor	109,130	dopamine	dopamine D-2 receptor	MESH:D004298	1813	Chemical	Gene	START_ENTITY|xcomp|binding binding|nmod|END_ENTITY	Single apomorphine pretreatment results in a rapid decline in high-affinity dopamine binding to the striatal dopamine_D-2_receptor .
1839781	0	dopamine	119,127	dopamine_D3_receptor	16,36	dopamine	dopamine D3 receptor	MESH:D004298	29238(Tax:10116)	Chemical	Gene	mRNA|compound|START_ENTITY comparison|nmod|mRNA Localization|dep|comparison Localization|nmod|mRNA mRNA|amod|END_ENTITY	Localization of dopamine_D3_receptor mRNA in the rat brain using in situ hybridization histochemistry : comparison with dopamine D2 receptor mRNA .
19900441	0	dopamine	106,114	dopamine_D3_receptor	160,180	dopamine	dopamine D3 receptor	MESH:D004298	13490(Tax:10090)	Chemical	Gene	antagonists|amod|START_ENTITY suppression|nmod|antagonists occur|nsubj|suppression occur|nmod|END_ENTITY	Locomotor activity induced by MK-801 is enhanced in dopamine_D3_receptor knockout mice but suppression by dopamine D3/D2 antagonists does not occur through the dopamine_D3_receptor .
23820985	0	dopamine	112,120	dopamine_D3_receptor	46,66	dopamine	dopamine D3 receptor	MESH:D004298	13490(Tax:10090)	Chemical	Gene	restores|dobj|START_ENTITY restores|nsubj|administration administration|nmod|agonists agonists|amod|END_ENTITY	Intranasal and subcutaneous administration of dopamine_D3_receptor agonists functionally restores nigrostriatal dopamine in MPTP-treated mice .
7875234	0	dopamine	25,33	dopamine_D3_receptor	59,79	dopamine	dopamine D3 receptor	MESH:D004298	29238(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY release|nmod|antagonist antagonist|amod|END_ENTITY	Modulation of mesolimbic dopamine release by the selective dopamine_D3_receptor antagonist , -LRB- + -RRB- - S_14297 .
7878047	0	dopamine	119,127	dopamine_D3_receptor	32,52	dopamine	dopamine D3 receptor	MESH:D004298	29238(Tax:10116)	Chemical	Gene	neurons|amod|START_ENTITY factor|nmod|neurons involvement|nmod|factor suggests|dobj|involvement suggests|nsubj|regulation regulation|nmod|expression expression|amod|END_ENTITY	A paradoxical regulation of the dopamine_D3_receptor expression suggests the involvement of an anterograde factor from dopamine neurons .
8858296	0	dopamine	96,104	dopamine_D3_receptor	42,62	dopamine	dopamine D3 receptor	MESH:D004298	29238(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	In vivo evidence for preferential role of dopamine_D3_receptor in the presynaptic regulation of dopamine release but not synthesis .
9482807	0	dopamine	15,23	dopamine_D3_receptor	74,94	dopamine	dopamine D3 receptor	MESH:D004298	13490(Tax:10090)	Chemical	Gene	release|amod|START_ENTITY Alterations|nmod|release function|nsubj|Alterations function|nmod|mice mice|amod|END_ENTITY	Alterations in dopamine release but not dopamine autoreceptor function in dopamine_D3_receptor mutant mice .
9707293	0	dopamine	116,124	dopamine_D3_receptor	51,71	dopamine	dopamine D3 receptor	MESH:D004298	29238(Tax:10116)	Chemical	Gene	autoreceptors|compound|START_ENTITY role|nmod|autoreceptors PD_128907|dep|role properties|dep|PD_128907 properties|nmod|agonist agonist|amod|END_ENTITY	Discriminative stimulus properties of the putative dopamine_D3_receptor agonist , -LRB- + -RRB- - PD_128907 : role of presynaptic dopamine D2 autoreceptors .
1826762	0	dopamine	78,86	dopamine_D5_receptor	32,52	dopamine	dopamine D5 receptor	MESH:D004298	1816	Chemical	Gene	affinity|nmod|START_ENTITY END_ENTITY|nmod|affinity	Cloning of the gene for a human dopamine_D5_receptor with higher affinity for dopamine than D1 .
25693197	0	dopamine	28,36	dopamine_d3_receptor	71,91	dopamine	dopamine d3 receptor	MESH:D004298	29238(Tax:10116)	Chemical	Gene	neurons|amod|START_ENTITY BDNF|nmod|neurons transfection|nmod|BDNF potentiates|nsubj|transfection potentiates|dobj|effect effect|nmod|agonist agonist|amod|END_ENTITY	The transfection of BDNF to dopamine neurons potentiates the effect of dopamine_d3_receptor agonist recovering the striatal innervation , dendritic spines and motor behavior in an aged rat model of Parkinson 's _ disease .
15213305	0	dopamine	49,57	dopamine_transporter	100,120	dopamine	dopamine transporter	MESH:D004298	6531	Chemical	Gene	efflux|compound|START_ENTITY efflux|acl|mediated mediated|nmod|END_ENTITY	Intracellular Ca2 + regulates amphetamine-induced dopamine efflux and currents mediated by the human dopamine_transporter .
25774383	0	dopamine	125,133	dopamine_transporter	89,109	dopamine	dopamine transporter	MESH:D004298	6531	Chemical	Gene	neurotransmission|amod|START_ENTITY END_ENTITY|nmod|neurotransmission	Rare autism-associated variants implicate syntaxin_1 -LRB- STX1 R26Q -RRB- phosphorylation and the dopamine_transporter -LRB- hDAT R51W -RRB- in dopamine neurotransmission and behaviors .
11483243	0	dopamine	140,148	enkephalin	111,121	dopamine	enkephalin	MESH:D004298	29237(Tax:10116)	Chemical	Gene	depletion|amod|START_ENTITY neurons|nmod|depletion END_ENTITY|dobj|neurons	Serotonin 2A receptor regulation of striatal neuropeptide gene expression is selective for tachykinin , but not enkephalin neurons following dopamine depletion .
1291031	0	dopamine	90,98	enkephalin	21,31	dopamine	enkephalin	MESH:D004298	29237(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|acl|inhibiting inhibiting|dobj|catabolism catabolism|compound|END_ENTITY	Effect of inhibiting enkephalin catabolism in the VTA on motor activity and extracellular dopamine .
16455064	0	dopamine	31,39	enkephalin	114,124	dopamine	enkephalin	MESH:D004298	29237(Tax:10116)	Chemical	Gene	agonist|amod|START_ENTITY administration|nmod|agonist reverses|nsubj|administration reverses|dobj|changes changes|nmod|END_ENTITY	Postnatal administration of D1 dopamine agonist reverses neonatal dopaminergic lesion-induced changes in striatal enkephalin and substance P systems .
1673340	0	dopamine	29,37	enkephalin	112,122	dopamine	enkephalin	MESH:D004298	29237(Tax:10116)	Chemical	Gene	agonist|compound|START_ENTITY effects|nmod|agonist effects|dep|content content|compound|END_ENTITY	Acute effects of D-1 and D-2 dopamine receptor agonist and antagonist drugs on basal ganglia -LSB- Met5 -RSB- - _ and _ -LSB- Leu5 -RSB- - enkephalin and neurotensin content in the rat .
1707718	0	dopamine	158,166	enkephalin	18,28	dopamine	enkephalin	MESH:D004298	29237(Tax:10116)	Chemical	Gene	depletion|amod|START_ENTITY extent|nmod|depletion dependent|nmod|extent dependent|nsubj|adaptation adaptation|nmod|neurons neurons|compound|END_ENTITY	The adaptation of enkephalin , tachykinin and monoamine neurons of the basal ganglia following neonatal dopaminergic denervation is dependent on the extent of dopamine depletion .
3017134	0	dopamine	36,44	enkephalin	11,21	dopamine	enkephalin	MESH:D004298	29237(Tax:10116)	Chemical	Gene	modulation|nmod|START_ENTITY modulation|compound|END_ENTITY	Endogenous enkephalin modulation of dopamine neurons in ventral tegmental area .
3110407	0	dopamine	85,93	enkephalin	23,33	dopamine	enkephalin	MESH:D004298	29237(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY antagonists|nmod|receptor receiving|dobj|antagonists rats|acl|receiving turnover|nmod|rats turnover|compound|END_ENTITY	Regulation of striatal enkephalin turnover in rats receiving antagonists of specific dopamine receptor subtypes .
3792452	0	dopamine	128,136	enkephalin	33,43	dopamine	enkephalin	MESH:D004298	29237(Tax:10116)	Chemical	Gene	agonist|amod|START_ENTITY administration|nmod|agonist induced|nmod|administration ganglia|acl|induced END_ENTITY|nmod|ganglia	Alterations in -LSB- Met5 -RSB- - _ and _ -LSB- Leu5 -RSB- enkephalin and neurotensin content in basal ganglia induced by the long-term administration of dopamine agonist and antagonist drugs to rats .
3934576	0	dopamine	11,19	enkephalin	72,82	dopamine	enkephalin	MESH:D004298	29237(Tax:10116)	Chemical	Gene	lesions|compound|START_ENTITY produce|nsubj|lesions produce|nmod|END_ENTITY	Mesolimbic dopamine lesions produce an augmented behavioral response to enkephalin .
6686641	0	dopamine	54,62	enkephalin	22,32	dopamine	enkephalin	MESH:D004298	29237(Tax:10116)	Chemical	Gene	analog|nmod|START_ENTITY analog|compound|END_ENTITY	Similar effects of an enkephalin analog on mesolimbic dopamine release and hyperactivity in rats .
7517280	0	dopamine	132,140	enkephalin	56,66	dopamine	enkephalin	MESH:D004298	29237(Tax:10116)	Chemical	Gene	accumbens|xcomp|START_ENTITY accumbens|nsubj|differences differences|nmod|response response|nmod|synthesis synthesis|compound|END_ENTITY	Rostrocaudal subregional differences in the response of enkephalin , dynorphin and substance P synthesis in rat nucleus accumbens to dopamine depletion .
7534387	0	dopamine	112,120	enkephalin	51,61	dopamine	enkephalin	MESH:D004298	29237(Tax:10116)	Chemical	Gene	denervation|compound|START_ENTITY RNAs|nmod|denervation P|dobj|RNAs P|nsubj|regulation regulation|nmod|END_ENTITY	Dopaminergic and muscarinic regulation of striatal enkephalin and substance P messenger RNAs following striatal dopamine denervation : effects of systemic and central administration of quinpirole and scopolamine .
8743739	0	dopamine	87,95	enkephalin	115,125	dopamine	enkephalin	MESH:D004298	29237(Tax:10116)	Chemical	Gene	deafferentation|compound|START_ENTITY effects|nmod|deafferentation suppresses|dobj|effects suppresses|nmod|END_ENTITY	Chronic dizocilpine_maleate -LRB- MK-801 -RRB- treatment suppresses the effects of nigrostriatal dopamine deafferentation on enkephalin but not on substance P expression in the rat striatum .
17096084	0	dopamine	53,61	epidermal_growth_factor	21,44	dopamine	epidermal growth factor	MESH:D004298	25313(Tax:10116)	Chemical	Gene	supersensitivity|amod|START_ENTITY induces|dobj|supersensitivity induces|nsubj|exposure exposure|nmod|END_ENTITY	Neonatal exposure to epidermal_growth_factor induces dopamine D2-like receptor supersensitivity in adult sensorimotor gating .
10998566	0	dopamine	55,63	erythropoietin	22,36	dopamine	erythropoietin	MESH:D004298	24335(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY END_ENTITY|nmod|release	Stimulating effect of erythropoietin on the release of dopamine and acetylcholine from the rat brain slice .
16368081	0	dopamine	61,69	erythropoietin	10,24	dopamine	erythropoietin	MESH:D004298	24335(Tax:10116)	Chemical	Gene	neurons|compound|START_ENTITY neuroprotection|nmod|neurons provides|dobj|neuroprotection provides|nsubj|END_ENTITY	Exogenous erythropoietin provides neuroprotection of grafted dopamine neurons in a rodent model of Parkinson 's _ disease .
16939505	0	dopamine	75,83	erythropoietin	30,44	dopamine	erythropoietin	MESH:D004298	2056	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Acute haemodynamic effects of erythropoietin alone and in combination with dopamine in a porcine model .
8764658	0	dopamine	135,143	extracellular_signal_regulated_kinase	19,56	dopamine	extracellular signal regulated kinase	MESH:D004298	24338(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of ERK -LRB- extracellular_signal_regulated_kinase -RRB- , part of the neurotrophin signal transduction cascade , in the rat mesolimbic dopamine system by chronic exposure to morphine or cocaine .
11181818	0	dopamine	20,28	fibroblast_growth_factor-2	32,58	dopamine	fibroblast growth factor-2	MESH:D004298	54250(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|expression expression|amod|END_ENTITY	Stimulatory role of dopamine on fibroblast_growth_factor-2 expression in rat striatum .
11223008	0	dopamine	112,120	fos	66,69	dopamine	fos	MESH:D004298	314322(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|scopolamine scopolamine|nmod|expression expression|compound|END_ENTITY	Comparative effects of scopolamine and quinpirole on the striatal fos expression induced by stimulation of D -LRB- 1 -RRB- dopamine receptors in the rat .
12603266	0	dopamine	34,42	fos	103,106	dopamine	fos	MESH:D004298	314322(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY stimulation|nmod|receptors causes|nsubj|stimulation causes|dobj|changes changes|nmod|expression expression|compound|END_ENTITY	Selective stimulation of striatal dopamine receptors of the D1 - or D2-class causes opposite changes of fos expression in the rat cerebral cortex .
15044039	0	dopamine	8,16	fos	59,62	dopamine	fos	MESH:D004298	314322(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|nmod|expression expression|compound|END_ENTITY	Role of dopamine D1 receptors in the striatal and cortical fos expression induced by the muscarinic agonist pilocarpine .
1668366	0	dopamine	44,52	fos	29,32	dopamine	fos	MESH:D004298	314322(Tax:10116)	Chemical	Gene	neurons|amod|START_ENTITY increases|nmod|neurons increases|dobj|protein protein|compound|END_ENTITY	Stress selectively increases fos protein in dopamine neurons innervating the prefrontal cortex .
1966822	0	dopamine	3,11	fos	40,43	dopamine	fos	MESH:D004298	314322(Tax:10116)	Chemical	Gene	START_ENTITY|ccomp|induce induce|dobj|proteins proteins|compound|END_ENTITY	D2 dopamine receptor antagonists induce fos and related proteins in rat striatal neurons .
7855736	0	dopamine	71,79	fos	33,36	dopamine	fos	MESH:D004298	314322(Tax:10116)	Chemical	Gene	activation|amod|START_ENTITY depends|nmod|activation depends|nsubj|END_ENTITY	Amphetamine - and cocaine-induced fos in the rat striatum depends on D2 dopamine receptor activation .
8535862	0	dopamine	9,17	fos	43,46	dopamine	fos	MESH:D004298	314322(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|nmod|induction induction|compound|END_ENTITY	Roles of dopamine D1 receptors in striatal fos protein induction associated with methamphetamine behavioral sensitization in rats .
2888024	0	dopamine	11,19	gastrin	44,51	dopamine	gastrin	MESH:D004298	100685087	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|nmod|responses responses|compound|END_ENTITY	Effects of dopamine receptor antagonists on gastrin and vomiting responses to apomorphine .
7433912	0	dopamine	15,23	gastrin	48,55	dopamine	gastrin	MESH:D004298	2520	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Effect of four dopamine receptor antagonists on gastrin secretion in healthy subjects .
8963684	0	dopamine	8,16	gastrin-releasing_peptide	86,111	dopamine	gastrin-releasing peptide	MESH:D004298	171101(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY release|nsubj|Role release|nmod|END_ENTITY	Role of dopamine in the inhibitory control of growth_hormone and prolactin release by gastrin-releasing_peptide .
19118592	0	dopamine	59,67	ghrelin	27,34	dopamine	ghrelin	MESH:D004298	59301(Tax:10116)	Chemical	Gene	increases|dobj|START_ENTITY increases|nsubj|administration administration|nmod|END_ENTITY	Systemic administration of ghrelin increases extracellular dopamine in the shell but not the core subdivision of the nucleus accumbens .
1871327	0	dopamine	71,79	growth_hormone	40,54	dopamine	growth hormone	MESH:D004298	2688	Chemical	Gene	agonist|amod|START_ENTITY response|nmod|agonist response|amod|END_ENTITY	The effect of methyltestosterone on the growth_hormone response to the dopamine receptor agonist , apomorphine .
1930878	0	dopamine	25,33	growth_hormone	57,71	dopamine	growth hormone	MESH:D004298	2688	Chemical	Gene	receptor|amod|START_ENTITY Stereospecificity|nmod|receptor Stereospecificity|acl|mediating mediating|dobj|response response|amod|END_ENTITY	Stereospecificity of the dopamine receptor mediating the growth_hormone response to apomorphine in man .
19604975	1	dopamine	92,100	growth_hormone	138,152	dopamine	growth hormone	MESH:D004298	81668(Tax:10116)	Chemical	Gene	turnover|amod|START_ENTITY Evidence|nmod|turnover Evidence|nmod|administration administration|amod|END_ENTITY	Evidence for discrete changes in dopamine and noradrenaline turnover following growth_hormone administration .
1966332	0	dopamine	11,19	growth_hormone	54,68	dopamine	growth hormone	MESH:D004298	2688	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of dopamine and bromocriptine on secretion of growth_hormone by pituitary growth_hormone secreting tumor in cell culture -RSB- .
1966332	0	dopamine	11,19	growth_hormone	82,96	dopamine	growth hormone	MESH:D004298	2688	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|tumor tumor|compound|END_ENTITY	-LSB- Effect of dopamine and bromocriptine on secretion of growth_hormone by pituitary growth_hormone secreting tumor in cell culture -RSB- .
2250145	0	dopamine	15,23	growth_hormone	55,69	dopamine	growth hormone	MESH:D004298	81668(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY Involvement|nmod|receptors Involvement|nmod|control control|nmod|secretion secretion|amod|END_ENTITY	Involvement of dopamine D1 receptors in the control of growth_hormone secretion in the rat .
25253414	0	dopamine	17,25	growth_hormone	45,59	dopamine	growth hormone	MESH:D004298	2688	Chemical	Gene	agonist|amod|START_ENTITY Bromocriptine|appos|agonist increases|nsubj|Bromocriptine increases|dobj|secretion secretion|amod|END_ENTITY	Bromocriptine , a dopamine agonist , increases growth_hormone secretion in a patient with acromegaly .
25442325	0	dopamine	24,32	growth_hormone	77,91	dopamine	growth hormone	MESH:D004298	102171600	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of hypothalamic dopamine on growth_hormone-releasing_hormone-induced growth_hormone secretion and thyrotropin-releasing hormone-induced prolactin secretion in goats .
2858802	0	dopamine	10,18	growth_hormone	68,82	dopamine	growth hormone	MESH:D004298	81668(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of dopamine , bombesin and cysteamine_hydrochloride on plasma growth_hormone response to synthetic growth_hormone-releasing_factor in rats .
2888666	0	dopamine	55,63	growth_hormone	76,90	dopamine	growth hormone	MESH:D004298	2688	Chemical	Gene	receptor|amod|START_ENTITY receptor|nmod|cells cells|amod|END_ENTITY	Further pharmacological characterization of a D-2-like dopamine receptor on growth_hormone producing cells in Lymnaea stagnalis .
3108691	0	dopamine	15,23	growth_hormone	27,41	dopamine	growth hormone	MESH:D004298	2688	Chemical	Gene	action|nmod|START_ENTITY action|nmod|release release|amod|END_ENTITY	Dual action of dopamine on growth_hormone release in vitro .
3234595	0	dopamine	10,18	growth_hormone	29,43	dopamine	growth hormone	MESH:D004298	2688	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of dopamine on plasma growth_hormone and prolactin concentrations under anaesthesia .
3553220	0	dopamine	64,72	growth_hormone	38,52	dopamine	growth hormone	MESH:D004298	2688	Chemical	Gene	growth_hormone|amod|START_ENTITY Role|dep|growth_hormone Role|nmod|dopamine dopamine|nmod|regulation regulation|nmod|secretion secretion|amod|END_ENTITY	Role of dopamine in the regulation of growth_hormone secretion : dopamine and bromocriptine augment growth_hormone -LRB- GH -RRB- - releasing hormone-stimulated GH secretion in normal man .
3553220	0	dopamine	8,16	growth_hormone	38,52	dopamine	growth hormone	MESH:D004298	2688	Chemical	Gene	START_ENTITY|nmod|regulation regulation|nmod|secretion secretion|amod|END_ENTITY	Role of dopamine in the regulation of growth_hormone secretion : dopamine and bromocriptine augment growth_hormone -LRB- GH -RRB- - releasing hormone-stimulated GH secretion in normal man .
3553220	0	dopamine	8,16	growth_hormone	99,113	dopamine	growth hormone	MESH:D004298	2688	Chemical	Gene	Role|nmod|START_ENTITY Role|dep|END_ENTITY	Role of dopamine in the regulation of growth_hormone secretion : dopamine and bromocriptine augment growth_hormone -LRB- GH -RRB- - releasing hormone-stimulated GH secretion in normal man .
7096541	0	dopamine	105,113	growth_hormone	40,54	dopamine	growth hormone	MESH:D004298	2688	Chemical	Gene	inhibition|amod|START_ENTITY adenomas|nmod|inhibition Evidence|dep|adenomas Evidence|nmod|receptors receptors|nmod|END_ENTITY	Evidence of dopamine receptors in human growth_hormone -LRB- GH -RRB- - secreting adenomas with concomitant study of dopamine inhibition of GH secretion in a perifusion system .
7096541	0	dopamine	12,20	growth_hormone	40,54	dopamine	growth hormone	MESH:D004298	2688	Chemical	Gene	receptors|amod|START_ENTITY receptors|nmod|END_ENTITY	Evidence of dopamine receptors in human growth_hormone -LRB- GH -RRB- - secreting adenomas with concomitant study of dopamine inhibition of GH secretion in a perifusion system .
7350194	0	dopamine	37,45	growth_hormone	10,24	dopamine	growth hormone	MESH:D004298	2688	Chemical	Gene	infusion|amod|START_ENTITY response|nmod|infusion response|amod|END_ENTITY	Increased growth_hormone response to dopamine infusion in insulin-dependent diabetic subjects : indication of possible blood-brain barrier abnormality .
8228731	0	dopamine	109,117	growth_hormone	39,53	dopamine	growth hormone	MESH:D004298	2688	Chemical	Gene	turnover|amod|START_ENTITY stimulation|nmod|turnover secretion|dep|stimulation secretion|compound|END_ENTITY	Thyrotrophin-releasing_hormone-induced growth_hormone secretion in domestic fowl : concomitant stimulation of dopamine turnover in the medial_basal_hypothalamus .
838847	0	dopamine	10,18	growth_hormone	29,43	dopamine	growth hormone	MESH:D004298	2688	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of dopamine on plasma growth_hormone and prolactin levels in normal and acromegalic subjects .
8963684	0	dopamine	8,16	growth_hormone	46,60	dopamine	growth hormone	MESH:D004298	81668(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|control control|nmod|END_ENTITY	Role of dopamine in the inhibitory control of growth_hormone and prolactin release by gastrin-releasing_peptide .
908278	0	dopamine	69,77	growth_hormone	10,24	dopamine	growth hormone	MESH:D004298	81668(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY butaclamol|appos|receptor effects|nmod|butaclamol END_ENTITY|dep|effects	Pulsatile growth_hormone and prolactin : effects of -LRB- + -RRB- _ butaclamol , a dopamine receptor blocking agent .
958594	0	dopamine	24,32	growth_hormone	112,126	dopamine	growth hormone	MESH:D004298	81668(Tax:10116)	Chemical	Gene	agonists|amod|START_ENTITY effects|nmod|agonists stimulating|nsubj|effects stimulating|dobj|hormone hormone|compound|END_ENTITY	Differential effects of dopamine agonists and haloperidol on release of prolactin , thyroid stimulating hormone , growth_hormone and luteinizing hormone in rats .
971548	0	dopamine	10,18	growth_hormone	48,62	dopamine	growth hormone	MESH:D004298	2688	Chemical	Gene	infusion|amod|START_ENTITY Effect|nmod|infusion Effect|nmod|levels levels|nmod|END_ENTITY	Effect of dopamine infusion on plasma levels of growth_hormone in normal subjects and in agromegalic patients .
993322	0	dopamine	14,22	growth_hormone	63,77	dopamine	growth hormone	MESH:D004298	2688	Chemical	Gene	receptor|amod|START_ENTITY Effect|nmod|receptor pimozide|nsubj|Effect pimozide|nmod|response response|amod|END_ENTITY	Effect of the dopamine receptor blocking agent pimozide on the growth_hormone response to arginine and exercise and on the spontaneous growth_hormone fluctuations .
10581397	0	dopamine	45,53	heme_oxygenase-1	14,30	dopamine	heme oxygenase-1	MESH:D004298	3162	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of heme_oxygenase-1 expression by dopamine in cultured C6_glioma and primary astrocytes .
19735655	0	dopamine	42,50	heme_oxygenase-1	89,105	dopamine	heme oxygenase-1	MESH:D004298	3162	Chemical	Gene	neurons|amod|START_ENTITY neurons|dep|peptide peptide|acl:relcl|induces induces|xcomp|END_ENTITY	C-terminal mechano_growth_factor protects dopamine neurons : a novel peptide that induces heme_oxygenase-1 .
3512396	0	dopamine	19,27	insulin	40,47	dopamine	insulin	MESH:D004298	3630	Chemical	Gene	infusion|compound|START_ENTITY infusion|nmod|END_ENTITY	Effect of low-dose dopamine infusion on insulin and glucagon release in fasting normal man .
3538366	0	dopamine	74,82	insulin	101,108	dopamine	insulin	MESH:D004298	483665(Tax:9615)	Chemical	Gene	doses|amod|START_ENTITY doses|nmod|END_ENTITY	Renal blood flow during acute ischaemic_heart_failure in dogs : effects of dopamine and high doses of insulin .
3544650	0	dopamine	107,115	insulin	134,141	dopamine	insulin	MESH:D004298	483665(Tax:9615)	Chemical	Gene	doses|amod|START_ENTITY doses|nmod|END_ENTITY	Total body oxygen consumption and haemodynamics during the treatment of acute ischaemic heart_failure with dopamine and high doses of insulin in dogs .
21415841	0	dopamine	30,38	insulin_receptor	51,67	dopamine	insulin receptor	MESH:D004298	24954(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Inhibitory effect of the D -LRB- 3 -RRB- dopamine receptor on insulin_receptor expression and function in vascular smooth muscle cells .
23001013	0	dopamine	9,17	insulin_receptor	55,71	dopamine	insulin receptor	MESH:D004298	24954(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY modulate|nsubj|receptors modulate|dobj|expression expression|nmod|END_ENTITY	Striatal dopamine receptors modulate the expression of insulin_receptor , IGF-1 and GLUT-3 in diabetic rats : effect of pyridoxine treatment .
7712203	0	dopamine	112,120	interleukin-1_alpha	20,39	dopamine	interleukin-1 alpha	MESH:D004298	24493(Tax:10116)	Chemical	Gene	activity|compound|START_ENTITY increasing|dobj|activity suppresses|advcl|increasing suppresses|nsubj|infusion infusion|amod|END_ENTITY	Continuous systemic interleukin-1_alpha infusion suppresses food intake without increasing lateral hypothalamic dopamine activity .
24348062	0	dopamine	11,19	leptin	23,29	dopamine	leptin	MESH:D004298	3952	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	Effects of dopamine on leptin release and leptin gene -LRB- OB -RRB- expression in adipocytes from obese and hypertensive patients .
21483433	0	dopamine	45,53	leptin_receptor	26,41	dopamine	leptin receptor	MESH:D004298	16847(Tax:10090)	Chemical	Gene	neurons|amod|START_ENTITY END_ENTITY|nmod|neurons	Selective deletion of the leptin_receptor in dopamine neurons produces anxiogenic-like behavior and increases dopaminergic activity in amygdala .
19735655	0	dopamine	42,50	mechano_growth_factor	11,32	dopamine	mechano growth factor	MESH:D004298	3479	Chemical	Gene	neurons|amod|START_ENTITY protects|dobj|neurons protects|nsubj|END_ENTITY	C-terminal mechano_growth_factor protects dopamine neurons : a novel peptide that induces heme_oxygenase-1 .
24742361	0	dopamine	69,77	miR-133b	57,65	dopamine	miR-133b	MESH:D004298	442890	Chemical	Gene	neurons|amod|START_ENTITY END_ENTITY|nmod|neurons	Orchestrated increase of dopamine and PARK mRNAs but not miR-133b in dopamine neurons in Parkinson 's _ disease .
10081977	0	dopamine	156,164	monoamine_oxidase	84,101	dopamine	monoamine oxidase	MESH:D004298	29253(Tax:10116)	Chemical	Gene	inhibits|nmod|START_ENTITY inhibits|dobj|END_ENTITY	Evidence that the neuronal nitric_oxide synthase inhibitor 7-nitroindazole inhibits monoamine_oxidase in the rat : in vivo effects on extracellular striatal dopamine and 3,4-dihydroxyphenylacetic _ acid .
10320000	0	dopamine	156,164	monoamine_oxidase	84,101	dopamine	monoamine oxidase	MESH:D004298	29253(Tax:10116)	Chemical	Gene	inhibits|nmod|START_ENTITY inhibits|dobj|END_ENTITY	Evidence that the neuronal nitric_oxide synthase inhibitor 7-nitroindazole inhibits monoamine_oxidase in the rat : in vivo effects on extracellular striatal dopamine and 3,4-dihydroxyphenylacetic _ acid .
16181414	1	dopamine	211,219	monoamine_oxidase	142,159	dopamine	monoamine oxidase	MESH:D004298	29253(Tax:10116)	Chemical	Gene	depletion|compound|START_ENTITY inhibition|nmod|depletion END_ENTITY|dobj|inhibition	In vivo selective brain monoamine_oxidase inhibition and prevention of MPTP-induced striatal dopamine depletion .
17965867	0	dopamine	77,85	monoamine_oxidase	45,62	dopamine	monoamine oxidase	MESH:D004298	29253(Tax:10116)	Chemical	Gene	metabolite|nmod|START_ENTITY metabolite|amod|END_ENTITY	Aggregation of alpha-synuclein by DOPAL , the monoamine_oxidase metabolite of dopamine .
3668521	0	dopamine	16,24	monoamine_oxidase	75,92	dopamine	monoamine oxidase	MESH:D004298	29253(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY Modification|nmod|metabolism Modification|nmod|inhibitors inhibitors|amod|END_ENTITY	Modification of dopamine and norepinephrine metabolism in the rat brain by monoamine_oxidase inhibitors .
6406646	0	dopamine	18,26	monoamine_oxidase	44,61	dopamine	monoamine oxidase	MESH:D004298	29253(Tax:10116)	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|nmod|forms forms|nmod|END_ENTITY	The metabolism of dopamine by both forms of monoamine_oxidase in the rat brain and its inhibition by cimoxatone .
6877035	0	dopamine	66,74	monoamine_oxidase	29,46	dopamine	monoamine oxidase	MESH:D004298	29253(Tax:10116)	Chemical	Gene	activities|nmod|START_ENTITY activities|amod|END_ENTITY	Localization of rat striatal monoamine_oxidase activities towards dopamine , serotonin and kynuramine by gradient centrifugation and nigro-striatal lesions .
9564622	0	dopamine	17,25	monoamine_oxidase	58,75	dopamine	monoamine oxidase	MESH:D004298	29253(Tax:10116)	Chemical	Gene	oxidation|nmod|START_ENTITY oxidation|nmod|END_ENTITY	The oxidation of dopamine and epinine by the two forms of monoamine_oxidase from rat liver .
11022024	0	dopamine	20,28	monoamine_oxidase-B	73,92	dopamine	monoamine oxidase-B	MESH:D004298	4129	Chemical	Gene	allele|amod|START_ENTITY Alcoholics|nmod|allele have|nsubj|Alcoholics have|dobj|activity activity|compound|END_ENTITY	Alcoholics with the dopamine receptor DRD2 A1 allele have lower platelet monoamine_oxidase-B activity than those with the A2 allele : a preliminary study .
1679846	0	dopamine	84,92	monoamine_oxidase-B	14,33	dopamine	monoamine oxidase-B	MESH:D004298	25750(Tax:10116)	Chemical	Gene	responses|nmod|START_ENTITY responses|amod|END_ENTITY	Inhibition of monoamine_oxidase-B by -LRB- - -RRB- - deprenyl potentiates neuronal responses to dopamine agonists but does not inhibit dopamine catabolism in the rat striatum .
6231746	0	dopamine	135,143	monoamine_oxidase-B	8,27	dopamine	monoamine oxidase-B	MESH:D004298	25750(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY changes|nmod|levels changes|nsubj|Role Role|nmod|induced induced|amod|END_ENTITY	Role of monoamine_oxidase-B in medroxyprogesterone_acetate -LRB- 17-acetoxy-6_alpha-methyl-4-pregnene-3 , _ 20-dione -RRB- induced changes in brain dopamine levels of rats .
7889269	0	dopamine	101,109	monoamine_oxidase-B	33,52	dopamine	monoamine oxidase-B	MESH:D004298	25750(Tax:10116)	Chemical	Gene	striatal|xcomp|START_ENTITY striatal|nsubj|effects effects|nmod|administration administration|nmod|inhibitors inhibitors|amod|END_ENTITY	The effects of administration of monoamine_oxidase-B inhibitors on rat striatal neurone responses to dopamine .
10428061	0	dopamine	33,41	monoamine_oxidase_B	104,123	dopamine	monoamine oxidase B	MESH:D004298	109731(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY changes|nmod|receptors changes|nmod|dynamics dynamics|nmod|mice mice|acl|lacking lacking|xcomp|END_ENTITY	Adaptive changes in postsynaptic dopamine receptors despite unaltered dopamine dynamics in mice lacking monoamine_oxidase_B .
10428061	0	dopamine	70,78	monoamine_oxidase_B	104,123	dopamine	monoamine oxidase B	MESH:D004298	109731(Tax:10090)	Chemical	Gene	dynamics|amod|START_ENTITY dynamics|nmod|mice mice|acl|lacking lacking|xcomp|END_ENTITY	Adaptive changes in postsynaptic dopamine receptors despite unaltered dopamine dynamics in mice lacking monoamine_oxidase_B .
20504633	0	dopamine	110,118	monoamine_oxidase_B	79,98	dopamine	monoamine oxidase B	MESH:D004298	708468(Tax:9544)	Chemical	Gene	serotonin|dep|START_ENTITY increases|xcomp|serotonin increases|nsubj|Milacemide Milacemide|appos|inhibitor inhibitor|nmod|END_ENTITY	Milacemide , the selective substrate and enzyme-activated specific inhibitor of monoamine_oxidase_B , increases dopamine but not serotonin in caudate nucleus of rhesus_monkey .
8183424	0	dopamine	49,57	monoamine_oxidase_B	15,34	dopamine	monoamine oxidase B	MESH:D004298	25750(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY inhibition|nmod|metabolism inhibition|nsubj|effects effects|nmod|END_ENTITY	The effects of monoamine_oxidase_B inhibition on dopamine metabolism in rats with nigro-striatal lesions .
833580	0	dopamine	151,159	monoamine_oxidase_B	86,105	dopamine	monoamine oxidase B	MESH:D004298	25750(Tax:10116)	Chemical	Gene	increase|nmod|START_ENTITY inhibitor|nmod|increase inhibitor|nmod|END_ENTITY	Desynchronization of electrical activity in rats induced by deprenyl -- an inhibitor of monoamine_oxidase_B -- and relationship with selective increase of dopamine and beta-phenylethylamine .
9564628	0	dopamine	19,27	monoamine_oxidase_B	85,104	dopamine	monoamine oxidase B	MESH:D004298	708468(Tax:9544)	Chemical	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Increased striatal dopamine production from L-DOPA following selective inhibition of monoamine_oxidase_B by R -LRB- + -RRB- - N-propargyl-1-aminoindan -LRB- rasagiline -RRB- in the monkey .
6622205	0	dopamine	108,116	monoamine_oxidase_type_A	24,48	dopamine	monoamine oxidase type A	MESH:D004298	29253(Tax:10116)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of rat brain monoamine_oxidase_type_A by 2-aminotetralin and tetrahydroisoquinoline analogues of dopamine .
9704592	0	dopamine	46,54	monoamine_oxidase_type_A_and_B	8,38	dopamine	monoamine oxidase type A and B	MESH:D004298	4128;4129	Chemical	Gene	metabolism|amod|START_ENTITY Role|nmod|metabolism Role|nmod|END_ENTITY	Role of monoamine_oxidase_type_A_and_B on the dopamine metabolism in discrete regions of the primate brain .
11145999	0	dopamine	133,141	nAChR	122,127	dopamine	nAChR	MESH:D004298	11441(Tax:10090)	Chemical	Gene	release|amod|START_ENTITY END_ENTITY|nmod|release	Nicotinic agonists stimulate acetylcholine release from mouse interpeduncular nucleus : a function mediated by a different nAChR than dopamine release from striatum .
18690106	0	dopamine	89,97	neurokinin_3_receptor	117,138	dopamine	neurokinin 3 receptor	MESH:D004298	21338(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Characterization of behavioral response to amphetamine , tyrosine hydroxylase levels , and dopamine receptor levels in neurokinin_3_receptor knockout mice .
10530507	0	dopamine	89,97	neuropeptide	120,132	dopamine	neuropeptide	MESH:D004298	379044(Tax:10116)	Chemical	Gene	depletion|amod|START_ENTITY influences|nmod|depletion alter|dobj|influences alter|nmod|expression expression|amod|END_ENTITY	Suppression of serotonin hyperinnervation does not alter the dysregulatory influences of dopamine depletion on striatal neuropeptide gene expression in rodent neonates .
16257473	0	dopamine	28,36	neuropeptide	65,77	dopamine	neuropeptide	MESH:D004298	379044(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|expression expression|amod|END_ENTITY	Comparison of basal and D-1 dopamine receptor agonist-stimulated neuropeptide gene expression in caudate-putamen and nucleus accumbens of ad libitum fed and food-restricted rats .
2432603	0	dopamine	14,22	neuropeptide	58,70	dopamine	neuropeptide	MESH:D004298	379044(Tax:10116)	Chemical	Gene	neurons|compound|START_ENTITY regulate|nsubj|neurons regulate|dobj|expression expression|nmod|mRNAs mRNAs|amod|END_ENTITY	Mesencephalic dopamine neurons regulate the expression of neuropeptide mRNAs in the rat forebrain .
7477761	0	dopamine	32,40	neuropeptide	53,65	dopamine	neuropeptide	MESH:D004298	379044(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY agonists|nsubj|effects agonists|nmod|expression expression|amod|END_ENTITY	Acute and subchronic effects of dopamine agonists on neuropeptide gene expression in the rat striatum .
1461360	0	dopamine	16,24	neuropeptide_Y	107,121	dopamine	neuropeptide Y	MESH:D004298	24604(Tax:10116)	Chemical	Gene	induced|nsubj|START_ENTITY induced|nmod|END_ENTITY	Norepinephrine , dopamine , and 5-HT release from perfused hypothalamus of the rat during feeding induced by neuropeptide_Y .
3528937	0	dopamine	12,20	neuropeptide_Y	39,53	dopamine	neuropeptide Y	MESH:D004298	24604(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|control control|nmod|END_ENTITY	The role of dopamine in the control of neuropeptide_Y neurons in the rat arcuate nucleus .
10095083	0	dopamine	100,108	neurotensin	35,46	dopamine	neurotensin	MESH:D004298	4922	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|mRNA mRNA|compound|END_ENTITY	Dopamine D-1 regulation of caudate neurotensin mRNA in the presence or absence of the nigrostriatal dopamine pathway .
10103090	0	dopamine	49,57	neurotensin	12,23	dopamine	neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	synergism|amod|START_ENTITY suppresses|dobj|synergism suppresses|nsubj|Blockade Blockade|nmod|receptors receptors|compound|END_ENTITY	Blockade of neurotensin receptors suppresses the dopamine D1/D2 synergism on immediate early gene expression in the rat brain .
10869842	0	dopamine	138,146	neurotensin	23,34	dopamine	neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	area|nmod|START_ENTITY applied|nmod|area applied|nsubj|effects effects|nmod|END_ENTITY	Comparative effects of neurotensin , neurotensin -LRB- 8-13 -RRB- and -LSB- D-Tyr -LRB- 11 -RRB- -RSB- neurotensin applied into the ventral tegmental area on extracellular dopamine in the rat prefrontal cortex and nucleus accumbens .
10973609	0	dopamine	78,86	neurotensin	47,58	dopamine	neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	8-13|nmod|START_ENTITY Effects|dep|8-13 Effects|nmod|microinjection microinjection|nmod|END_ENTITY	Effects of prefrontal cortex microinjection of neurotensin - -LRB- 8-13 -RRB- on midbrain dopamine and non-dopamine cell firing .
11413237	0	dopamine	38,46	neurotensin	11,22	dopamine	neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	efflux|compound|START_ENTITY efflux|compound|END_ENTITY	Endogenous neurotensin down-regulates dopamine efflux in the nucleus accumbens as revealed by SR-142948A , a selective neurotensin receptor antagonist .
11413237	0	dopamine	38,46	neurotensin	118,129	dopamine	neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	efflux|compound|START_ENTITY accumbens|nsubj|efflux accumbens|advcl|revealed revealed|nmod|SR-142948A SR-142948A|appos|antagonist antagonist|compound|END_ENTITY	Endogenous neurotensin down-regulates dopamine efflux in the nucleus accumbens as revealed by SR-142948A , a selective neurotensin receptor antagonist .
11471555	0	dopamine	25,33	neurotensin	88,99	dopamine	neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|neurons neurons|nmod|nigra nigra|nmod|receptor receptor|compound|END_ENTITY	In vivo gene transfer to dopamine neurons of rat substantia nigra via the high-affinity neurotensin receptor .
12070755	0	dopamine	68,76	neurotensin	108,119	dopamine	neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	START_ENTITY|acl|evoked evoked|nmod|ejection ejection|compound|END_ENTITY	The neurotensin receptor antagonist SR_142948A blocks the efflux of dopamine evoked in nucleus accumbens by neurotensin ejection into the ventral tegmental area .
12070755	0	dopamine	68,76	neurotensin	4,15	dopamine	neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	efflux|nmod|START_ENTITY blocks|dobj|efflux blocks|nsubj|SR_142948A SR_142948A|amod|END_ENTITY	The neurotensin receptor antagonist SR_142948A blocks the efflux of dopamine evoked in nucleus accumbens by neurotensin ejection into the ventral tegmental area .
12111825	0	dopamine	128,136	neurotensin	34,45	dopamine	neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	D1|amod|START_ENTITY stimulation|nmod|D1 mediated|nmod|stimulation mediated|nsubjpass|increase increase|nmod|outflow outflow|compound|END_ENTITY	d-Amphetamine-induced increase in neurotensin and neuropeptide_Y outflow in the ventral striatum is mediated via stimulation of dopamine D1 and D2/3 receptors .
1350070	0	dopamine	35,43	neurotensin	20,31	dopamine	neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	inhibition|amod|START_ENTITY END_ENTITY|nmod|inhibition	Opposite effects of neurotensin on dopamine inhibition in different regions of the rat brain : an iontophoretic study .
1351780	0	dopamine	42,50	neurotensin	112,123	dopamine	neurotensin	MESH:D004298	4922	Chemical	Gene	D1|amod|START_ENTITY receptors|nmod|D1 Role|nmod|receptors mediated|nsubj|Role mediated|nmod|systems systems|compound|END_ENTITY	Role of N-methyl-D-aspartate receptors in dopamine D1 - , but not D2 - , mediated changes in striatal and accumbens neurotensin systems .
1361113	0	dopamine	61,69	neurotensin	139,150	dopamine	neurotensin	MESH:D004298	4922	Chemical	Gene	START_ENTITY|nmod|mechanism mechanism|nmod|action action|nmod|END_ENTITY	Intramembrane interactions between neurotensin receptors and dopamine D2 receptors as a major mechanism for the neuroleptic-like action of neurotensin .
1436486	0	dopamine	113,121	neurotensin	73,84	dopamine	neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	efflux|compound|START_ENTITY underlying|nmod|efflux underlying|dobj|effects effects|nmod|END_ENTITY	Pharmacological evidence for common mechanisms underlying the effects of neurotensin and neuroleptics on in vivo dopamine efflux in the rat nucleus accumbens .
15030383	0	dopamine	88,96	neurotensin	24,35	dopamine	neurotensin	MESH:D004298	67405(Tax:10090)	Chemical	Gene	efflux|compound|START_ENTITY involvement|nmod|efflux involvement|nmod|receptor receptor|amod|END_ENTITY	Specific involvement of neurotensin type 1 receptor in the neurotensin-mediated in vivo dopamine efflux using knock-out mice .
1655979	0	dopamine	87,95	neurotensin	47,58	dopamine	neurotensin	MESH:D004298	4922	Chemical	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|moieties moieties|nmod|END_ENTITY	Interactions between the argininyl moieties of neurotensin and the catechol protons of dopamine .
1697899	0	dopamine	81,89	neurotensin	26,37	dopamine	neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of acute and daily neurotensin and enkephalin treatments on extracellular dopamine in the nucleus accumbens .
1701223	0	dopamine	59,67	neurotensin	11,22	dopamine	neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of neurotensin on regional brain concentrations of dopamine , serotonin and their main metabolites .
17448541	0	dopamine	11,19	neurotensin	147,158	dopamine	neurotensin	MESH:D004298	4922	Chemical	Gene	pathways|nsubj|START_ENTITY pathways|nmod|peptides peptides|compound|END_ENTITY	Mesolimbic dopamine and cortico-accumbens glutamate afferents as major targets for the regulation of the ventral striato-pallidal GABA pathways by neurotensin peptides .
1776128	0	dopamine	35,43	neurotensin	11,22	dopamine	neurotensin	MESH:D004298	4922	Chemical	Gene	neurons|compound|START_ENTITY Effects|nmod|neurons Effects|nmod|END_ENTITY	Effects of neurotensin on midbrain dopamine neurons : are they mediated by formation of a neurotensin-dopamine complex ?
17988654	0	dopamine	65,73	neurotensin	4,15	dopamine	neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	enhances|dobj|START_ENTITY enhances|nsubj|NT69L NT69L|amod|END_ENTITY	The neurotensin analog NT69L enhances medial prefrontal cortical dopamine and acetylcholine efflux : potentiation of risperidone - , but not haloperidol - , induced dopamine efflux .
1899007	0	dopamine	11,19	neurotensin	67,78	dopamine	neurotensin	MESH:D004298	4922	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Mesolimbic dopamine mediates gastric mucosal protection by central neurotensin .
19682375	0	dopamine	37,45	neurotensin	22,33	dopamine	neurotensin	MESH:D004298	4922	Chemical	Gene	release|amod|START_ENTITY END_ENTITY|nmod|release	Presynaptic action of neurotensin on dopamine release through inhibition of D -LRB- 2 -RRB- receptor function .
1981163	0	dopamine	50,58	neurotensin	30,41	dopamine	neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	binding|amod|START_ENTITY reduces|dobj|binding reduces|nsubj|injection injection|nmod|END_ENTITY	Intraventricular injection of neurotensin reduces dopamine D2 agonist binding in rat forebrain and intermediate lobe of the pituitary gland .
1981481	0	dopamine	122,130	neurotensin	40,51	dopamine	neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	activation|amod|START_ENTITY independent|nmod|activation independent|nsubj|Evidence Evidence|dep|slices slices|nsubj|effect effect|nmod|END_ENTITY	Evidence that the stimulatory effect of neurotensin on dopamine release in rat nucleus accumbens slices is independent of dopamine D2-receptor activation .
1981481	0	dopamine	55,63	neurotensin	40,51	dopamine	neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY END_ENTITY|nmod|release	Evidence that the stimulatory effect of neurotensin on dopamine release in rat nucleus accumbens slices is independent of dopamine D2-receptor activation .
20504524	0	dopamine	14,22	neurotensin	46,57	dopamine	neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY Modulation|nmod|receptor binding|nsubj|Modulation binding|nmod|END_ENTITY	Modulation of dopamine D1 receptor binding by neurotensin in the rat striatum .
2087439	0	dopamine	15,23	neurotensin	49,60	dopamine	neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|effect effect|nmod|END_ENTITY	Involvement of dopamine in the central effect of neurotensin on intestinal motility in rats .
2338657	0	dopamine	25,33	neurotensin	53,64	dopamine	neurotensin	MESH:D004298	4922	Chemical	Gene	release|amod|START_ENTITY desensitization|nmod|release induced|nsubj|desensitization induced|nmod|fragments fragments|compound|END_ENTITY	Rapid desensitization of dopamine release induced by neurotensin and neurotensin fragments .
2352647	0	dopamine	26,34	neurotensin	11,22	dopamine	neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY END_ENTITY|nmod|release	Effects of neurotensin on dopamine release and metabolism in the rat striatum and nucleus accumbens : cross-validation using in vivo voltammetry and microdialysis .
2593006	0	dopamine	11,19	neurotensin	42,53	dopamine	neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	depletion|amod|START_ENTITY depletion|nmod|END_ENTITY	Effects of dopamine depletion on striatal neurotensin : biochemical and immunohistochemical studies .
2888514	0	dopamine	112,120	neurotensin	30,41	dopamine	neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	regions|compound|START_ENTITY alterations|nmod|regions alterations|nmod|END_ENTITY	Stress-induced alterations in neurotensin , somatostatin and corticotropin-releasing_factor in mesotelencephalic dopamine system regions .
2987745	0	dopamine	119,127	neurotensin	15,26	dopamine	neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	agonist|amod|START_ENTITY administration|nmod|agonist induced|nmod|administration hyperactivity|acl|induced NT|nmod|hyperactivity effects|dep|NT effects|nmod|-RSB- -RSB-|compound|END_ENTITY	The effects of neurotensin and -LSB- D-Tyr11 -RSB- - NT on the hyperactivity induced by intra-accumbens administration of a potent dopamine receptor agonist .
3133572	0	dopamine	46,54	neurotensin	29,40	dopamine	neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	neurons|amod|START_ENTITY co-localization|nmod|neurons co-localization|nmod|END_ENTITY	Extensive co-localization of neurotensin with dopamine in rat meso-cortico-frontal dopaminergic neurons .
3150806	0	dopamine	88,96	neurotensin	146,157	dopamine	neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY stimulation|nmod|receptors produced|nmod|stimulation activation|acl|produced Antagonization|nmod|activation caused|nsubj|Antagonization caused|nmod|injections injections|nmod|END_ENTITY	Antagonization of the behavioral activation produced by direct stimulation of forebrain dopamine receptors caused by intraaccumbens injections of neurotensin .
3208829	0	dopamine	84,92	neurotensin	10,21	dopamine	neurotensin	MESH:D004298	4922	Chemical	Gene	release|amod|START_ENTITY 8-13|nmod|release Effect|dep|8-13 Effect|nmod|END_ENTITY	Effect of neurotensin and its fragments neurotensin - -LRB- 1-6 -RRB- and neurotensin - -LRB- 8-13 -RRB- on dopamine release from cat striatum .
3350051	0	dopamine	47,55	neurotensin	4,15	dopamine	neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	neurons|compound|START_ENTITY excites|dobj|neurons excites|nsubj|xenopsin xenopsin|amod|END_ENTITY	The neurotensin analog xenopsin excites nigral dopamine neurons .
3485291	0	dopamine	96,104	neurotensin	30,41	dopamine	neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY stimulating|dobj|release inhibits|advcl|stimulating inhibits|nsubj|evidence evidence|dep|END_ENTITY	Further evidence that central neurotensin inhibits pituitary prolactin secretion by stimulating dopamine release from the hypothalamus .
6083874	0	dopamine	64,72	neurotensin	10,21	dopamine	neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY regulation|nmod|receptors P|nmod|regulation P|nsubj|Effect Effect|nmod|END_ENTITY	Effect of neurotensin , substance P and TRH on the regulation of dopamine receptors in rat brain .
6682440	0	dopamine	39,47	neurotensin	16,27	dopamine	neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	systems|compound|START_ENTITY END_ENTITY|nmod|systems	Interactions of neurotensin with brain dopamine systems : biochemical and behavioral studies .
6811728	0	dopamine	12,20	neurotensin	49,60	dopamine	neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	metabolites|amod|START_ENTITY Increase|nmod|metabolites Increase|nmod|END_ENTITY	Increase in dopamine metabolites in rat brain by neurotensin .
7722490	0	dopamine	118,126	neurotensin	12,23	dopamine	neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	evoked|nmod|START_ENTITY release|amod|evoked haloperidol|nmod|release accumbens|amod|haloperidol effect|nmod|accumbens potentiates|dobj|effect potentiates|nsubj|Blockade Blockade|nmod|receptor receptor|compound|END_ENTITY	Blockade of neurotensin receptor by SR_48692 potentiates the facilitatory effect of haloperidol on the evoked in vivo dopamine release in the rat nucleus accumbens .
7936192	0	dopamine	78,86	neurotensin	32,43	dopamine	neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY reduction|nmod|release associated|nmod|reduction associated|nsubjpass|Facilitation Facilitation|nmod|release release|nmod|END_ENTITY	Facilitation of GABA release by neurotensin is associated with a reduction of dopamine release in rat nucleus accumbens .
7981879	0	dopamine	19,27	neurotensin	51,62	dopamine	neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	D2|amod|START_ENTITY D2|nmod|expression expression|compound|END_ENTITY	Opposing roles for dopamine D2 and D3 receptors on neurotensin mRNA expression in nucleus accumbens .
8358601	0	dopamine	124,132	neurotensin	16,27	dopamine	neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	expression|compound|START_ENTITY decline|nmod|expression relationship|acl|decline relationship|dep|Blunting Blunting|nmod|response response|compound|END_ENTITY	Blunting of the neurotensin mRNA response to haloperidol in the striatum of aging rats : possible relationship to decline in dopamine D2 receptor expression .
8472756	0	dopamine	78,86	neurotensin	15,26	dopamine	neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY rat|dobj|receptors modulates|xcomp|rat modulates|nsubj|fragment fragment|amod|END_ENTITY	The C-terminal neurotensin - -LRB- 8-13 -RRB- fragment potently modulates rat neostriatal dopamine D2 receptors .
9144645	0	dopamine	83,91	neurotensin	4,15	dopamine	neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	agonist|amod|START_ENTITY modify|nmod|agonist fails|xcomp|modify fails|nsubj|SR_48692 SR_48692|compound|END_ENTITY	The neurotensin antagonist SR_48692 fails to modify the behavioural responses to a dopamine D1 receptor agonist in the rat .
9681955	0	dopamine	39,47	neurotensin	24,35	dopamine	neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY END_ENTITY|nmod|release	Differential effects of neurotensin on dopamine release in the caudal and rostral nucleus accumbens : a combined in vivo electrochemical and electrophysiological study .
9705573	0	dopamine	102,110	neurotensin	30,41	dopamine	neurotensin	MESH:D004298	299757(Tax:10116)	Chemical	Gene	neurons|compound|START_ENTITY activation|nmod|neurons mediates|dobj|activation mediates|nsubj|evidence evidence|dep|END_ENTITY	Pharmacological evidence that neurotensin mediates prolactin-induced activation of tuberoinfundibular dopamine neurons .
9736759	0	dopamine	72,80	neurotensin	50,61	dopamine	neurotensin	MESH:D004298	4922	Chemical	Gene	regions|amod|START_ENTITY efflux|nmod|regions efflux|compound|END_ENTITY	Atypical antipsychotic drugs selectively increase neurotensin efflux in dopamine terminal regions .
11356924	0	dopamine	81,89	norepinephrine_transporter	106,132	dopamine	norepinephrine transporter	MESH:D004298	83511(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY release|nmod|END_ENTITY	Protein kinase C and intracellular calcium are required for amphetamine-mediated dopamine release via the norepinephrine_transporter in undifferentiated PC12 cells .
12444505	0	dopamine	11,19	norepinephrine_transporter	45,71	dopamine	norepinephrine transporter	MESH:D004298	83511(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY mediated|nsubjpass|transport mediated|nmod|END_ENTITY	Astroglial dopamine transport is mediated by norepinephrine_transporter .
11681760	0	dopamine	25,33	part_1	45,51	dopamine	part 1	MESH:D004298	25859	Chemical	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	`` Hit-and-run '' actions at dopamine receptors , part_1 : Mechanism of action of atypical antipsychotics .
11775041	0	dopamine	118,126	part_1	86,92	dopamine	part 1	MESH:D004298	25859	Chemical	Gene	receptors|amod|START_ENTITY actions|nmod|receptors actions|amod|END_ENTITY	Dopamine system stabilizers , aripiprazole , and the next generation of antipsychotics , part_1 , `` Goldilocks '' actions at dopamine receptors .
12590617	0	dopamine	121,129	part_1	32,38	dopamine	part 1	MESH:D004298	25859	Chemical	Gene	regulate|xcomp|START_ENTITY hitchhiker|dep|regulate hitchhiker|advmod|END_ENTITY	Neurotransmission of cognition , part_1 , Dopamine is a hitchhiker in frontal cortex : norepinephrine transporters regulate dopamine .
12128251	0	dopamine	11,19	parvalbumin	68,79	dopamine	parvalbumin	MESH:D004298	25269(Tax:10116)	Chemical	Gene	START_ENTITY|acl:relcl|express express|dobj|END_ENTITY	Effects of dopamine and estrogen upon cortical neurons that express parvalbumin in vitro .
24888524	0	dopamine	54,62	parvalbumin	35,46	dopamine	parvalbumin	MESH:D004298	5816	Chemical	Gene	hyperfunction|amod|START_ENTITY END_ENTITY|nmod|hyperfunction	A fundamental role for hippocampal parvalbumin in the dopamine hyperfunction associated with schizophrenia .
14604817	0	dopamine	4,12	phospholipase_D	31,46	dopamine	phospholipase D	MESH:D004298	2822	Chemical	Gene	receptor|compound|START_ENTITY mediates|nsubj|receptor mediates|xcomp|END_ENTITY	D2s dopamine receptor mediates phospholipase_D and antiproliferation .
15500962	0	dopamine	3,11	phospholipase_D	31,46	dopamine	phospholipase D	MESH:D004298	2822	Chemical	Gene	receptor|amod|START_ENTITY activates|nsubj|receptor activates|dep|END_ENTITY	D3 dopamine receptor activates phospholipase_D through a pertussis toxin-insensitive pathway .
20021566	0	dopamine	3,11	phospholipase_D	46,61	dopamine	phospholipase D	MESH:D004298	2822	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	D3 dopamine receptor signals to activation of phospholipase_D through a complex with Rho .
25818009	0	dopamine	114,122	polo-like_kinases_2_and_3	78,103	dopamine	polo-like kinases 2 and 3	MESH:D004298	10769;1263	Chemical	Gene	neurons|compound|START_ENTITY END_ENTITY|nmod|neurons	Ser129 phosphorylation of endogenous a-synuclein induced by overexpression of polo-like_kinases_2_and_3 in nigral dopamine neurons is not detrimental to their survival and function .
1312196	0	dopamine	71,79	preproenkephalin	36,52	dopamine	preproenkephalin	MESH:D004298	5179	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|mRNA mRNA|compound|END_ENTITY	Differential regulation of striatal preproenkephalin mRNA by D1 and D2 dopamine receptors .
10420090	0	dopamine	69,77	prolactin	16,25	dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	action|amod|START_ENTITY escape|nmod|action secretion|nmod|escape secretion|compound|END_ENTITY	Potentiation of prolactin secretion following lactotrope escape from dopamine action .
10420091	0	dopamine	69,77	prolactin	16,25	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	action|amod|START_ENTITY escape|nmod|action secretion|nmod|escape secretion|compound|END_ENTITY	Potentiation of prolactin secretion following lactotrope escape from dopamine action .
10831224	0	dopamine	54,62	prolactin	93,102	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	turnover|amod|START_ENTITY exposure|nmod|turnover Effects|nmod|exposure Effects|nmod|END_ENTITY	Effects of subchronic alternating cadmium exposure on dopamine turnover and plasma levels of prolactin , GH and ACTH .
11356724	0	dopamine	60,68	prolactin	16,25	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	activity|compound|START_ENTITY secretion|nmod|activity secretion|nsubj|Dissociation Dissociation|nmod|END_ENTITY	Dissociation of prolactin secretion from tuberoinfundibular dopamine activity in late pregnant rats .
11800285	0	dopamine	19,27	prolactin	58,67	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	turnover|amod|START_ENTITY effects|nmod|turnover effects|nmod|END_ENTITY	Cadmium effects on dopamine turnover and plasma levels of prolactin , GH and ACTH .
11914590	0	dopamine	37,45	prolactin	14,23	dopamine	prolactin	MESH:D004298	100303694(Tax:9103)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of prolactin secretion by dopamine at the level of the hypothalamus in the turkey .
12123859	0	dopamine	94,102	prolactin	18,27	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	neurons|compound|START_ENTITY mediated|nmod|neurons mediated|nsubjpass|control control|nmod|secretion secretion|compound|END_ENTITY	Opioid control of prolactin secretion in late pregnant rats is mediated by tuberoinfundibular dopamine neurons .
12145343	0	dopamine	26,34	prolactin	52,61	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	inhibition|amod|START_ENTITY preferences|nmod|inhibition preferences|nmod|secretion secretion|compound|END_ENTITY	G protein preferences for dopamine D2 inhibition of prolactin secretion and DNA synthesis in GH4 pituitary cells .
12530588	0	dopamine	102,110	prolactin	71,80	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	changes|amod|START_ENTITY inhibit|nmod|changes inhibit|dobj|secretion secretion|nmod|END_ENTITY	Oral cadmium exposure throughout puberty does not inhibit secretion of prolactin , GH and ACTH through dopamine metabolism changes in male rat .
1323801	0	dopamine	91,99	prolactin	14,23	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Evidence that prolactin mediates the stimulatory effects of estrogen on tuberoinfundibular dopamine neurons in female rats .
1355520	0	dopamine	144,152	prolactin	83,92	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY involvement|nmod|release secretion|dep|involvement secretion|compound|END_ENTITY	Intraventricular administration of thyrotrophin-releasing_hormone -LRB- TRH -RRB- suppresses prolactin secretion and synthesis : a possible involvement of dopamine release by TRH from rat hypothalamus .
1360151	0	dopamine	127,135	prolactin	65,74	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	agonists|amod|START_ENTITY series|nmod|agonists induced|nmod|series suppression|acl|induced suppression|compound|END_ENTITY	Effects of N-ethoxycarbonyl-2-ethoxy-1 ,2 - dihydroquinoline on the prolactin suppression induced by a series of full and partial dopamine D2 receptor agonists in male rats .
1369597	0	dopamine	13,21	prolactin	48,57	dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	Influence of dopamine on the altered release of prolactin , luteinizing hormone , and follicle-stimulating hormone induced by interleukin-2 in vitro .
14724063	0	dopamine	143,151	prolactin	11,20	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	Changes|nmod|START_ENTITY Changes|nmod|mechanisms mechanisms|amod|END_ENTITY	Changes of prolactin regulatory mechanisms in aging : 24-h rhythms of serum prolactin and median eminence and adenohypophysial concentration of dopamine , serotonin , -LRB- gamma-aminobutyric_acid , taurine and somatostatin in young and aged rats .
1473523	0	dopamine	108,116	prolactin	41,50	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	vitro|advcl|START_ENTITY released|advcl|vitro released|nsubj|Effect Effect|nmod|reserpine reserpine|nmod|inhibition inhibition|nmod|END_ENTITY	Effect of reserpine on the inhibition of prolactin released from different pituitary constructs in vitro by dopamine , bromocriptine and apomorphine .
1488102	0	dopamine	99,107	prolactin	53,62	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	antagonism|amod|START_ENTITY revealed|nmod|antagonism rats|acl|revealed surges|nmod|rats surges|nsubj|regulation regulation|nmod|END_ENTITY	Differential regulation of the nocturnal and diurnal prolactin surges in pregnant rats revealed by dopamine receptor antagonism .
15585363	0	dopamine	56,64	prolactin	82,91	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	mechanism|nmod|START_ENTITY effects|nmod|mechanism effects|nmod|secretion secretion|compound|END_ENTITY	Toxic effects of cadmium on the regulatory mechanism of dopamine and serotonin on prolactin secretion in adult male rats .
1585003	8	dopamine	1556,1564	prolactin	1664,1673	dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	is|advcl|START_ENTITY is|parataxis|required required|nmod|suppression suppression|nmod|secretion secretion|compound|END_ENTITY	There is , however , evidence for increased pituitary sensitivity to dopamine under short daylength , so increased dopamine concentrations may not be required for suppression of prolactin secretion at this time .
1585003	8	dopamine	1601,1609	prolactin	1664,1673	dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	concentrations|compound|START_ENTITY required|nsubjpass|concentrations required|nmod|suppression suppression|nmod|secretion secretion|compound|END_ENTITY	There is , however , evidence for increased pituitary sensitivity to dopamine under short daylength , so increased dopamine concentrations may not be required for suppression of prolactin secretion at this time .
1600472	0	dopamine	15,23	prolactin	27,36	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|levels levels|amod|END_ENTITY	The effects of dopamine on prolactin mRNA levels in rat pituitary cells in culture .
1601282	0	dopamine	64,72	prolactin	40,49	dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Seasonal and lactational effects on the prolactin response to a dopamine antagonist and TRH in the Bennett 's wallaby -LRB- Macropus rufogriseus rufogriseus -RRB- .
16725998	0	dopamine	10,18	prolactin	85,94	dopamine	prolactin	MESH:D004298	396965(Tax:9823)	Chemical	Gene	agonists|amod|START_ENTITY Effect|nmod|agonists Effect|appos|removal removal|nmod|concentrations concentrations|compound|END_ENTITY	Effect of dopamine agonists or antagonists , TRH , stress and piglet removal on plasma prolactin concentrations in lactating gilts .
1740166	0	dopamine	31,39	prolactin	73,82	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	START_ENTITY|acl|associated associated|nmod|types types|nmod|END_ENTITY	Turnover rates of hypothalamic dopamine associated with the two types of prolactin surges during pseudopregnancy in rats .
1753713	0	dopamine	144,152	prolactin	10,19	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	agonist|amod|START_ENTITY treated|nmod|agonist level|acl|treated level|compound|END_ENTITY	Decreased prolactin level in secretory granules and their increased exocytosis in estrogen-induced pituitary_hyperplasia in rats treated with a dopamine agonist .
17850459	0	dopamine	42,50	prolactin	104,113	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	D|amod|START_ENTITY experience|nmod|D experience|dep|mechanism mechanism|nmod|secretion secretion|compound|END_ENTITY	Reproductive experience and expression of dopamine D -LRB- 2 -RRB- receptor mRNA : a possible mechanism for reduced prolactin secretion in primiparous rats .
1834494	0	dopamine	22,30	prolactin	90,99	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY isoform|nmod|receptor mediate|nsubj|isoform mediate|dobj|repression repression|nmod|promoter promoter|compound|END_ENTITY	Either isoform of the dopamine D2 receptor can mediate dopaminergic repression of the rat prolactin promoter .
1835974	0	dopamine	60,68	prolactin	22,31	dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	control|nmod|START_ENTITY control|nmod|promoters promoters|compound|END_ENTITY	Inhibitory control of prolactin and Pit-1 gene promoters by dopamine .
19215442	0	dopamine	27,35	prolactin	67,76	dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	inhibition|compound|START_ENTITY mechanisms|nmod|inhibition mechanisms|nmod|secretion secretion|compound|END_ENTITY	Differential mechanisms of dopamine and somatostatin inhibition of prolactin secretion from anterior pituitary cells .
19215460	0	dopamine	124,132	prolactin	91,100	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	alter|advcl|START_ENTITY alter|dobj|release release|compound|END_ENTITY	Prolactin implants in the hypothalamus inhibit prolactin surges during pregnancy and alter prolactin release in response to dopamine receptor blockade .
20152122	0	dopamine	34,42	prolactin	62,71	dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	release|amod|START_ENTITY reduces|dobj|release reduces|advcl|enhancing enhancing|dobj|secretion secretion|compound|END_ENTITY	Excitatory neuromodulator reduces dopamine release , enhancing prolactin secretion .
2035258	0	dopamine	10,18	prolactin	41,50	dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	medication|amod|START_ENTITY medication|nmod|pituitary_adenomas pituitary_adenomas|amod|END_ENTITY	Effect of dopamine agonist medication on prolactin producing pituitary_adenomas .
20553721	0	dopamine	63,71	prolactin	87,96	dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	effect|nmod|START_ENTITY mediates|dobj|effect mediates|nmod|release release|compound|END_ENTITY	D2 Dopamine receptor subtype mediates the inhibitory effect of dopamine on TRH-induced prolactin release from the bullfrog pituitary .
2111892	0	dopamine	33,41	prolactin	11,20	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	Changes|acl|START_ENTITY Changes|nmod|response response|compound|END_ENTITY	Changes of prolactin response to dopamine during the rat estrous cycle .
21128120	0	dopamine	110,118	prolactin	97,106	dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	therapy|amod|START_ENTITY sensitivity|nmod|therapy sensitivity|nmod|END_ENTITY	Insulin sensitivity and lipid profile in prolactinoma patients before and after normalization of prolactin by dopamine agonist therapy .
2114004	0	dopamine	10,18	prolactin	106,115	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	withdrawal|compound|START_ENTITY potentiates|nsubj|withdrawal potentiates|dobj|thyrotropin thyrotropin|acl|releasing releasing|dobj|release release|nmod|END_ENTITY	Transient dopamine withdrawal differentially potentiates thyrotropin releasing hormone-induced release of prolactin of various ages .
21153292	0	dopamine	74,82	prolactin	42,51	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	stage|xcomp|START_ENTITY stage|nmod|response response|compound|END_ENTITY	Effects of the estrous cycle stage on the prolactin secretory response to dopamine in vitro .
21533991	0	dopamine	15,23	prolactin	65,74	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	stabilizers|amod|START_ENTITY Effects|nmod|stabilizers Effects|dep|- -|dep|OSU6162 OSU6162|nmod|secretion secretion|compound|END_ENTITY	Effects of the dopamine stabilizers -LRB- S -RRB- - -LRB- - -RRB- - OSU6162 and ACR16 on prolactin secretion in drug-naive and monoamine-depleted rats .
223069	0	dopamine	25,33	prolactin	48,57	dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|secretion secretion|compound|END_ENTITY	Endogenous opiates block dopamine inhibition of prolactin secretion in vitro .
2250257	0	dopamine	115,123	prolactin	88,97	dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	antagonist|amod|START_ENTITY suppress|nmod|antagonist suppress|dobj|release release|nmod|END_ENTITY	Melatonin implants prevent the onset of seasonal quiescence and suppress the release of prolactin in response to a dopamine antagonist in the Bennett 's wallaby -LRB- Macropus rufogriseus rufogriseus -RRB- .
23404929	0	dopamine	143,151	prolactin	70,79	dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	metabolism|amod|START_ENTITY affecting|dobj|metabolism neurometabolic_conditions|acl|affecting diagnosis|nmod|neurometabolic_conditions aid|nmod|diagnosis END_ENTITY|xcomp|aid	Establishment of paediatric age-related reference intervals for serum prolactin to aid in the diagnosis of neurometabolic_conditions affecting dopamine metabolism .
23851570	0	dopamine	39,47	prolactin	96,105	dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	gene|amod|START_ENTITY variant|nmod|gene effect|nmod|variant alleles|nsubj|effect alleles|nmod|levels levels|compound|END_ENTITY	The effect of the Taq1A variant in the dopamine D receptor gene and common CYP2D6 alleles on prolactin levels in risperidone-treated boys .
2456219	0	dopamine	41,49	prolactin	28,37	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY END_ENTITY|nmod|release	Comparison of the effect of prolactin on dopamine release from the rat dorsal and ventral striatum and from the mediobasal hypothalamus superfused in vitro .
2464129	0	dopamine	126,134	prolactin	20,29	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY cells|dep|role cells|amod|Discrepancy Discrepancy|nmod|END_ENTITY	Discrepancy between prolactin -LRB- PRL -RRB- messenger ribonucleic_acid and PRL content in rat fetal pituitary cells : possible role of dopamine .
2495929	0	dopamine	103,111	prolactin	34,43	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY increase|dep|role increase|nmod|END_ENTITY	Time-dependent increase in plasma prolactin after pituitary stalk section : role of posterior pituitary dopamine .
2524012	0	dopamine	20,28	prolactin	81,90	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY antagonism|nsubj|Effect antagonism|nmod|secretion secretion|compound|END_ENTITY	Effect of transient dopamine antagonism on thyrotropin-releasing_hormone-induced prolactin secretion in the serotonin-blocked , estrogen-treated ovariectomized rats .
2567101	0	dopamine	68,76	prolactin	15,24	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Suppression Suppression|nmod|release release|compound|END_ENTITY	Suppression of prolactin release and mRNA accumulation by two novel dopamine agonist agents .
2569498	0	dopamine	12,20	prolactin	83,92	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY agonists|nsubj|receptor agonists|parataxis|enhance enhance|dobj|secretion secretion|compound|END_ENTITY	The partial dopamine receptor agonists -LRB----RRB- -3 - PPP and transdihydrolisuride enhance prolactin secretion in female but not in male rats .
2579087	0	dopamine	38,46	prolactin	67,76	dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	action|nmod|START_ENTITY Mechanism|nmod|action Mechanism|nmod|secretion secretion|compound|END_ENTITY	Mechanism of the inhibitory action of dopamine and somatostatin on prolactin secretion from human lactotrophs in culture .
2607250	0	dopamine	54,62	prolactin	31,40	dopamine	prolactin	MESH:D004298	443317(Tax:9940)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|inhibition inhibition|nmod|END_ENTITY	Direct pituitary inhibition of prolactin secretion by dopamine and noradrenaline in sheep .
26298751	0	dopamine	4,12	prolactin	46,55	dopamine	prolactin	MESH:D004298	280901(Tax:9913)	Chemical	Gene	domperidone|amod|START_ENTITY increases|nsubj|domperidone increases|dobj|concentration concentration|compound|END_ENTITY	The dopamine antagonist domperidone increases prolactin concentration and enhances milk production in dairy cows .
2725844	0	dopamine	28,36	prolactin	129,138	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	rates|amod|START_ENTITY alterations|nmod|rates alterations|nmod|surge surge|compound|END_ENTITY	Differential alterations in dopamine turnover rates in the stalk-median eminence and posterior pituitary during the preovulatory prolactin surge .
2860004	0	dopamine	10,18	prolactin	36,45	dopamine	prolactin	MESH:D004298	19109(Tax:10090)	Chemical	Gene	neurons|amod|START_ENTITY Number|nmod|neurons predicts|nsubj|Number predicts|dobj|levels levels|compound|END_ENTITY	Number of dopamine neurons predicts prolactin levels in two inbred mouse strains .
2866817	0	dopamine	90,98	prolactin	32,41	dopamine	prolactin	MESH:D004298	19109(Tax:10090)	Chemical	Gene	neurons|compound|START_ENTITY number|nmod|neurons relationship|nmod|number differences|dep|relationship differences|nmod|content content|compound|END_ENTITY	Strain differences in pituitary prolactin content : relationship to number of hypothalamic dopamine neurons .
2879753	0	dopamine	11,19	prolactin	65,74	dopamine	prolactin	MESH:D004298	443317(Tax:9940)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of dopamine and somatostatin on phorbol_ester-stimulated prolactin and growth_hormone secretion .
2908233	0	dopamine	56,64	prolactin	85,94	dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	START_ENTITY|nmod|hormone hormone|compound|END_ENTITY	Actions of pertussis toxin on the inhibitory effects of dopamine and somatostatin on prolactin and growth hormone release from ovine anterior pituitary cells .
2968488	0	dopamine	24,32	prolactin	44,53	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	blockers|nmod|START_ENTITY reduce|nsubj|blockers reduce|dobj|secretion secretion|compound|END_ENTITY	Pure uptake blockers of dopamine can reduce prolactin secretion : studies with diclofensine .
2980713	0	dopamine	85,93	prolactin	35,44	dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	agonists|amod|START_ENTITY adenomas|nmod|agonists adenomas|nsubj|morphometry morphometry|nmod|secreting secreting|compound|END_ENTITY	Light microscopical morphometry of prolactin secreting adenomas under treatment with dopamine agonists .
3007174	0	dopamine	4,12	prolactin	50,59	dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	stimulation|compound|START_ENTITY elevates|nsubj|stimulation elevates|dobj|levels levels|compound|END_ENTITY	D-1 dopamine receptor stimulation elevates plasma prolactin levels .
3081830	0	dopamine	12,20	prolactin	55,64	dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	receptors|amod|START_ENTITY Function|nmod|receptors Function|dep|responses responses|compound|END_ENTITY	Function of dopamine receptors in Parkinson 's _ disease : prolactin responses .
3090397	0	dopamine	53,61	prolactin	127,136	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	antagonism|compound|START_ENTITY effects|nmod|antagonism comparison|nmod|effects induced|nsubj|comparison induced|dobj|release release|compound|END_ENTITY	A comparison of the effects of suckling or transient dopamine antagonism on thyrotropin-releasing_hormone and suckling induced prolactin release in lactating rats .
3090629	0	dopamine	61,69	prolactin	23,32	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	agonist|amod|START_ENTITY effect|nmod|agonist cells|nmod|effect cells|compound|END_ENTITY	-LSB- Lysosomal activity in prolactin cells under the effect of a dopamine agonist -RSB- .
3097561	0	dopamine	34,42	prolactin	90,99	dopamine	prolactin	MESH:D004298	443317(Tax:9940)	Chemical	Gene	START_ENTITY|xcomp|participate participate|nmod|release release|nmod|END_ENTITY	Evidence that opioid peptides and dopamine participate in the suckling-induced release of prolactin in the ewe .
34491	0	dopamine	15,23	prolactin	73,82	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	effects|acl|START_ENTITY effects|nmod|release release|compound|END_ENTITY	The effects of dopamine , bromocriptine , lergotrile and metoclopramide on prolactin release from continuously perfused columns of isolated rat pituitary cells .
3485291	0	dopamine	96,104	prolactin	61,70	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY stimulating|dobj|release inhibits|advcl|stimulating inhibits|dobj|secretion secretion|compound|END_ENTITY	Further evidence that central neurotensin inhibits pituitary prolactin secretion by stimulating dopamine release from the hypothalamus .
3561698	0	dopamine	37,45	prolactin	107,116	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	Responsiveness|nmod|START_ENTITY neurons|nsubj|Responsiveness neurons|nmod|actions actions|nmod|END_ENTITY	Responsiveness of tuberoinfundibular dopamine neurons in the aged female rat to the stimulatory actions of prolactin .
3622405	0	dopamine	13,21	prolactin	54,63	dopamine	prolactin	MESH:D004298	101843376	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|cell cell|compound|END_ENTITY	Evidence for dopamine receptor-mediated inhibition of prolactin cell function in the female Syrian_hamster .
3705888	0	dopamine	42,50	prolactin	19,28	dopamine	prolactin	MESH:D004298	19109(Tax:10090)	Chemical	Gene	secretion|xcomp|START_ENTITY secretion|nsubj|sensitivity sensitivity|nmod|END_ENTITY	The sensitivity of prolactin secretion to dopamine changes during pregnancy in mice .
3753596	0	dopamine	45,53	prolactin	64,73	dopamine	prolactin	MESH:D004298	100303694(Tax:9103)	Chemical	Gene	injection|nmod|START_ENTITY Influence|nmod|injection Influence|nmod|END_ENTITY	Influence of cerebroventricular injection of dopamine on plasma prolactin and LH levels of postlaying and broody turkey hens .
3755608	0	dopamine	74,82	prolactin	38,47	dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	CQP201-403|amod|START_ENTITY effect|nmod|CQP201-403 suppressant|dobj|effect suppressant|nsubj|Description Description|nmod|course course|nmod|END_ENTITY	Description of the time course of the prolactin suppressant effect of the dopamine agonist CQP201-403 by an integrated pharmacokinetic-pharmacodynamic model .
3902607	0	dopamine	28,36	prolactin	58,67	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|regulation regulation|nmod|secretion secretion|compound|END_ENTITY	Involvement of hypothalamic dopamine in the regulation of prolactin secretion .
3921384	0	dopamine	193,201	prolactin	54,63	dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	stimulation|amod|START_ENTITY evidence|nmod|stimulation Effect|dep|evidence Effect|nmod|administration administration|nmod|END_ENTITY	Effect of dihydroergokryptine administration on serum prolactin and growth_hormone levels in normal , hyperprolactinaemic and acromegalic subjects : evidence of potent and long-lasting pituitary dopamine receptor stimulation .
3950867	0	dopamine	41,49	prolactin	77,86	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|neurons neurons|nmod|secretion secretion|compound|END_ENTITY	Delayed activation of tuberoinfundibular dopamine neurons and suppression of prolactin secretion in the rat after morphine administration .
3977547	0	dopamine	33,41	prolactin	11,20	dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	Evaluating|advcl|START_ENTITY Evaluating|dobj|response response|compound|END_ENTITY	Evaluating prolactin response to dopamine agonists in schizophrenia .
4007050	0	dopamine	84,92	prolactin	40,49	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	increased|dobj|START_ENTITY increased|nsubj|inhibition inhibition|nmod|secretion secretion|compound|END_ENTITY	Phencyclidine-induced inhibition of rat prolactin secretion : increased portal blood dopamine .
4027295	0	dopamine	19,27	prolactin	40,49	dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	infusion|compound|START_ENTITY infusion|nmod|END_ENTITY	Effect of low-dose dopamine infusion on prolactin and thyrotropin secretion in preterm infants with hyaline_membrane_disease .
410638	0	dopamine	13,21	prolactin	83,92	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|volume volume|nmod|nuclei nuclei|nmod|cells cells|compound|END_ENTITY	Influence of dopamine and thyrotropin_releasing_hormone on the volume of nuclei of prolactin cells in rat adenohypophysis in vitro .
410826	0	dopamine	11,19	prolactin	52,61	dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	infusion|amod|START_ENTITY Failure|nmod|infusion Failure|acl|suppress suppress|dobj|response response|compound|END_ENTITY	Failure of dopamine infusion to suppress the plasma prolactin response to sulpiride in normal and hyperprolactinemic subjects .
410827	0	dopamine	15,23	prolactin	51,60	dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	START_ENTITY|dobj|augmentation augmentation|nmod|secretion secretion|compound|END_ENTITY	Effects of CNS dopamine augmentation on stimulated prolactin secretion .
411328	0	dopamine	51,59	prolactin	14,23	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|secretion secretion|compound|END_ENTITY	Inhibition of prolactin secretion and synthesis by dopamine , noradrenaline and pilocarpine in cultured rat pituitary_tumour cells .
421124	0	dopamine	23,31	prolactin	10,19	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY END_ENTITY|nmod|synthesis	Effect of prolactin on dopamine synthesis in medial basal hypothalamus : evidence for a short loop feedback .
45469	0	dopamine	10,18	prolactin	90,99	dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	agonist|amod|START_ENTITY Effect|nmod|agonist therapy|nsubj|Effect therapy|nmod|secretion secretion|nmod|END_ENTITY	Effect of dopamine agonist -LRB- Lergotrile mesylate -RRB- therapy on twenty-four hour secretion of prolactin in treated Parkinson 's _ disease .
508205	0	dopamine	36,44	prolactin	95,104	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	lithium|nmod|START_ENTITY effects|nmod|lithium reflected|nsubj|effects reflected|nmod|inhibition inhibition|nmod|secretion secretion|compound|END_ENTITY	Acute effects of lithium on central dopamine and serotonin activity reflected by inhibition of prolactin and growth_hormone secretion in the rat .
527660	0	dopamine	30,38	prolactin	53,62	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|secretion secretion|compound|END_ENTITY	Failure of opiates to reverse dopamine inhibition of prolactin secretion in vitro .
6110459	0	dopamine	86,94	prolactin	68,77	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	antagonism|amod|START_ENTITY END_ENTITY|nmod|antagonism	Chlorpromazine , haloperidol , metoclopramide and domperidone release prolactin through dopamine antagonism at low concentrations but paradoxically inhibit prolactin release at high concentrations .
6139285	0	dopamine	73,81	prolactin	25,34	dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	receptor|compound|START_ENTITY cause|dobj|receptor cause|nsubj|Elevation Elevation|acl|circulating circulating|dobj|concentrations concentrations|compound|END_ENTITY	Elevation of circulating prolactin concentrations may not cause striatal dopamine receptor supersensitivity .
6149167	0	dopamine	102,110	prolactin	37,46	dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	glands|amod|START_ENTITY release|nmod|glands release|nsubj|effects effects|nmod|END_ENTITY	Neurotransmitter effects on in vitro prolactin and growth_hormone release from fowl pituitary glands : dopamine and noradrenaline .
6180941	0	dopamine	11,19	prolactin	23,32	dopamine	prolactin	MESH:D004298	443317(Tax:9940)	Chemical	Gene	Actions|nmod|START_ENTITY Actions|nmod|secretion secretion|compound|END_ENTITY	Actions of dopamine on prolactin secretion and cyclic_AMP metabolism in ovine pituitary cells .
6250393	0	dopamine	96,104	prolactin	158,167	dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	inhibition|amod|START_ENTITY study|nmod|inhibition study|nmod|secretion secretion|compound|END_ENTITY	Calcium and the secretory cycle of prolactin cells : a cytochemical and ultrastructural study of dopamine inhibition and monobutyryl_cyclic_AMP-stimulation of prolactin secretion .
6408670	0	dopamine	73,81	prolactin	50,59	dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	blockade|amod|START_ENTITY study|nmod|blockade study|nmod|responses responses|compound|END_ENTITY	A preliminary study of sex-related differences in prolactin responses to dopamine blockade and insulin hypoglycemia and in penfluridol plasma levels in schizophrenic patients .
6436160	2	dopamine	127,135	prolactin	63,72	dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	infusion|compound|START_ENTITY thyrotropin-releasing_hormone|nmod|infusion Restoration|acl|thyrotropin-releasing_hormone Restoration|nmod|response response|compound|END_ENTITY	Restoration of the prolactin response to thyrotropin-releasing_hormone by low-dose dopamine infusion in women with pathological hyperprolactinemia .
6480800	0	dopamine	63,71	prolactin	17,26	dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	START_ENTITY|nsubj|profiles profiles|compound|END_ENTITY	Twenty four-hour prolactin profiles and prolactin responses to dopamine in long distance running women .
6507613	0	dopamine	19,27	prolactin	48,57	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	result|amod|START_ENTITY result|nmod|surges surges|nmod|secretion secretion|compound|END_ENTITY	Brief decreases in dopamine result in surges of prolactin secretion in monkeys .
6541994	0	dopamine	17,25	prolactin	66,75	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Adenohypophysial dopamine content during physiological changes in prolactin secretion .
6580661	0	dopamine	103,111	prolactin	6,15	dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	hypothesis|amod|START_ENTITY implications|nmod|hypothesis response|dep|implications response|compound|END_ENTITY	Serum prolactin response to chlorpromazine and psychopathology in schizophrenics : implications for the dopamine hypothesis .
6617716	0	dopamine	30,38	prolactin	94,103	dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	diisobutyric_ester|amod|START_ENTITY diisobutyric_ester|nmod|levels levels|compound|END_ENTITY	Effect of the orally absorbed dopamine analogue N-methyldopamine diisobutyric_ester on plasma prolactin levels .
6705740	0	dopamine	77,85	prolactin	15,24	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	secretion|xcomp|START_ENTITY secretion|nsubj|Stimulation Stimulation|nmod|END_ENTITY	Stimulation of prolactin secretion after short term or pulsatile exposure to dopamine in superfused anterior pituitary cell aggregates .
6745164	0	dopamine	51,59	prolactin	107,116	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	START_ENTITY|parataxis|serum serum|dobj|concentration concentration|compound|END_ENTITY	Pharmacological manipulation of anterior pituitary dopamine content in the male rat : relationship to serum prolactin concentration and lysosomal enzyme activity .
6778075	0	dopamine	14,22	prolactin	110,119	dopamine	prolactin	MESH:D004298	443317(Tax:9940)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|centre centre|acl|producing producing|dobj|factor factor|compound|END_ENTITY	The effect of dopamine on the release of prolactin in sheep with lesions of the hypothetical centre producing prolactin inhibiting factor -LRB- PIF -RRB- .
6778075	0	dopamine	14,22	prolactin	41,50	dopamine	prolactin	MESH:D004298	443317(Tax:9940)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of dopamine on the release of prolactin in sheep with lesions of the hypothetical centre producing prolactin inhibiting factor -LRB- PIF -RRB- .
6818058	0	dopamine	31,39	prolactin	54,63	dopamine	prolactin	MESH:D004298	443317(Tax:9940)	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|secretion secretion|compound|END_ENTITY	Involvement of calcium ions in dopamine inhibition of prolactin secretion from sheep pituitary cells .
6822635	0	dopamine	35,43	prolactin	56,65	dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Differential effects of a low dose dopamine infusion on prolactin secretion in normal and hyperprolactinemic subjects .
6838618	0	dopamine	47,55	prolactin	76,85	dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	inhibition|amod|START_ENTITY interact|nmod|inhibition 2_Hydroxyestradiol|acl|interact Failure|nmod|2_Hydroxyestradiol Failure|nmod|secretion secretion|compound|END_ENTITY	Failure of 2_Hydroxyestradiol to interact with dopamine inhibition of human prolactin secretion in vitro and with dopamine receptors of prolactin-secreting adenomas .
6850041	0	dopamine	112,120	prolactin	79,88	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Pituitary function during the sexual maturation of the male rat : inhibition of prolactin secretion by exogenous dopamine .
6860978	0	dopamine	160,168	prolactin	94,103	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	rates|amod|START_ENTITY increases|nmod|rates inhibits|dobj|increases inhibits|nsubj|antiserum antiserum|compound|END_ENTITY	Prolactin increases the activity of tuberoinfundibular and nigroneostriatal dopamine neurons : prolactin antiserum inhibits the haloperidol-induced increases in dopamine synthesis rates in median eminence and striatum of rats .
6860978	0	dopamine	76,84	prolactin	94,103	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	neurons|compound|START_ENTITY activity|nmod|neurons increases|dobj|activity increases|parataxis|inhibits inhibits|nsubj|antiserum antiserum|compound|END_ENTITY	Prolactin increases the activity of tuberoinfundibular and nigroneostriatal dopamine neurons : prolactin antiserum inhibits the haloperidol-induced increases in dopamine synthesis rates in median eminence and striatum of rats .
6861715	0	dopamine	132,140	prolactin	91,100	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|amod|END_ENTITY	The inhibition of phosphatidylinositol turnover : a possible postreceptor mechanism for the prolactin secretion-inhibiting effect of dopamine .
6872271	0	dopamine	46,54	prolactin	14,23	dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	infusion|compound|START_ENTITY secretion|nmod|infusion secretion|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of prolactin secretion by low-dose dopamine infusion in patients with hyperprolactinaemia .
6884430	0	dopamine	14,22	prolactin	53,62	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of two dopamine agonists , TL-99 and 3-PPP , on prolactin secretion in the rat .
6891802	0	dopamine	36,44	prolactin	23,32	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	control|nmod|START_ENTITY control|nmod|END_ENTITY	Stimulatory control of prolactin by dopamine .
7132736	0	dopamine	37,45	prolactin	9,18	dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	responsiveness|xcomp|START_ENTITY responsiveness|nsubj|END_ENTITY	Impaired prolactin responsiveness to dopamine antagonists in acromegaly .
7173110	0	dopamine	21,29	prolactin	33,42	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Involvement of brain dopamine in prolactin secretion induced by a synthetic Met5-enkephalin analogue in rats .
7226569	0	dopamine	10,18	prolactin	37,46	dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	infusion|amod|START_ENTITY Effect|nmod|infusion Effect|nmod|concentration concentration|compound|END_ENTITY	Effect of dopamine infusion on serum prolactin concentration in normal and hyperprolactinaemic subjects .
7246736	0	dopamine	89,97	prolactin	14,23	dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	effects|nmod|START_ENTITY Resumption|dep|effects Resumption|nmod|secretion secretion|compound|END_ENTITY	Resumption of prolactin secretion after dopaminergic inhibition : differential effects of dopamine and its agonists .
7301051	0	dopamine	32,40	prolactin	53,62	dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	agonists|amod|START_ENTITY agonists|nmod|secretion secretion|compound|END_ENTITY	Effect of two indirectly acting dopamine agonists on prolactin secretion in normo - and hyperprolactinemic subjects : comparison with the effect of nomifensine .
744042	0	dopamine	55,63	prolactin	78,87	dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	START_ENTITY|dobj|inhibition inhibition|nmod|secretion secretion|compound|END_ENTITY	In vitro supersensitivity of the anterior pituitary to dopamine inhibition of prolactin secretion .
7459063	0	dopamine	46,54	prolactin	92,101	dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	receptors|compound|START_ENTITY receptors|acl|involved involved|nmod|control control|nmod|secretion secretion|compound|END_ENTITY	-LSB- Stereospecificity of hypothalamo-hypophysial dopamine receptors involved in the control of prolactin secretion in normal man : effects of sulpiride stereoisomers -RSB- .
7530063	0	dopamine	70,78	prolactin	57,66	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY P|nmod|release P|nmod|effect effect|nmod|END_ENTITY	Involvement of hypothalamic substance P in the effect of prolactin on dopamine release .
7781960	0	dopamine	42,50	prolactin	54,63	dopamine	prolactin	MESH:D004298	100303694(Tax:9103)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|secretion secretion|compound|END_ENTITY	The stimulatory and inhibitory effects of dopamine on prolactin secretion in the turkey .
7890021	0	dopamine	153,161	prolactin	9,18	dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	assay|amod|START_ENTITY inhibited|nmod|assay inhibited|nmod|END_ENTITY	In vitro prolactin but not LH and FSH release is inhibited by compounds in extracts of Agnus castus : direct evidence for a dopaminergic principle by the dopamine receptor assay .
7977731	0	dopamine	36,44	prolactin	15,24	dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	withdrawal|amod|START_ENTITY release|nmod|withdrawal release|compound|END_ENTITY	Stimulation of prolactin release by dopamine withdrawal : role of membrane hyperpolarization .
7977732	0	dopamine	36,44	prolactin	15,24	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	withdrawal|amod|START_ENTITY release|nmod|withdrawal release|compound|END_ENTITY	Stimulation of prolactin release by dopamine withdrawal : role of calcium influx .
8097329	0	dopamine	12,20	prolactin	69,78	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	Infusion|nmod|START_ENTITY stimulates|nsubj|Infusion stimulates|dobj|release release|nmod|END_ENTITY	Infusion of dopamine at low concentrations stimulates the release of prolactin from alpha-methyl-p-tyrosine-treated rats .
8474497	0	dopamine	12,20	prolactin	67,76	dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	receptors|amod|START_ENTITY Function|nmod|receptors Function|dep|response response|compound|END_ENTITY	Function of dopamine receptors in young-onset Parkinson 's _ disease : prolactin response .
891746	0	dopamine	13,21	prolactin	41,50	dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	infusion|amod|START_ENTITY infusion|nmod|END_ENTITY	Influence of dopamine infusion on plasma prolactin released by kidney capsule transplanted anterior pituitaries .
9059216	0	dopamine	19,27	prolactin	55,64	dopamine	prolactin	MESH:D004298	5617	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|concentrations concentrations|nmod|END_ENTITY	Effect of low-dose dopamine on serum concentrations of prolactin in critically ill patients .
9822799	0	dopamine	37,45	prolactin	14,23	dopamine	prolactin	MESH:D004298	100303694(Tax:9103)	Chemical	Gene	peptide|amod|START_ENTITY secretion|nmod|peptide secretion|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of prolactin secretion by dopamine and vasoactive intestinal peptide at the level of the pituitary in the turkey .
9871483	0	dopamine	35,43	prolactin	110,119	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	Changes|nmod|START_ENTITY Changes|dep|mechanism mechanism|dep|secretion secretion|compound|END_ENTITY	Changes in mediobasal hypothalamic dopamine and GABA release : a possible mechanism underlying taurine-induced prolactin secretion .
9886815	0	dopamine	38,46	prolactin	96,105	dopamine	prolactin	MESH:D004298	24683(Tax:10116)	Chemical	Gene	activities|compound|START_ENTITY altered|nsubjpass|activities altered|nmod|lactation lactation|dep|role role|nmod|END_ENTITY	Neuropeptide_Y and tuberoinfundibular dopamine activities are altered during lactation : role of prolactin .
11120384	0	dopamine	92,100	protein_kinase_A	65,81	dopamine	protein kinase A	MESH:D004298	25636(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Long-term effects of postnatal amphetamine treatment on striatal protein_kinase_A activity , dopamine D -LRB- 1 -RRB- - like and D -LRB- 2 -RRB- - like binding sites , and dopamine content .
11279288	0	dopamine	57,65	protein_kinase_A	34,50	dopamine	protein kinase A	MESH:D004298	25636(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY END_ENTITY|nmod|receptor	Examination of the involvement of protein_kinase_A in D2 dopamine receptor antagonist-induced immediate early gene expression .
1175682	0	dopamine	10,18	renin	22,27	dopamine	renin	MESH:D004298	403838(Tax:9615)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of dopamine on renin secretion in the anesthetized dog .
2467083	0	dopamine	48,56	renin	77,82	dopamine	renin	MESH:D004298	24715(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY endowed|nmod|receptors endowed|xcomp|mediating mediating|dobj|release release|compound|END_ENTITY	Rat juxtaglomerular cells are endowed with DA-1 dopamine receptors mediating renin release .
2663252	0	dopamine	31,39	renin	61,66	dopamine	renin	MESH:D004298	5972	Chemical	Gene	production|nmod|START_ENTITY production|nmod|patients patients|nmod|essential_hypertension essential_hypertension|compound|END_ENTITY	Attenuated renal production of dopamine in patients with low renin essential_hypertension .
2856715	0	dopamine	53,61	renin	35,40	dopamine	renin	MESH:D004298	24715(Tax:10116)	Chemical	Gene	effect|acl|START_ENTITY effect|nmod|intake intake|nmod|response response|compound|END_ENTITY	The effect of sodium intake on the renin response to dopamine in superfused rat renal cortical cells .
2948826	0	dopamine	99,107	renin	51,56	dopamine	renin	MESH:D004298	5972	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|peptide peptide|nmod|activity activity|compound|END_ENTITY	The effect of atrial natriuretic peptide on plasma renin activity , plasma aldosterone , and urinary dopamine in man .
2988086	0	dopamine	10,18	renin	62,67	dopamine	renin	MESH:D004298	24715(Tax:10116)	Chemical	Gene	blockade|compound|START_ENTITY Effect|nmod|blockade Effect|nmod|content content|compound|END_ENTITY	Effect of dopamine and dopamine-receptor blockade on in vitro renin release , tissue renin content and tissue cyclic_AMP content in the rat .
2988086	0	dopamine	10,18	renin	84,89	dopamine	renin	MESH:D004298	24715(Tax:10116)	Chemical	Gene	blockade|compound|START_ENTITY Effect|nmod|blockade Effect|nmod|content content|compound|END_ENTITY	Effect of dopamine and dopamine-receptor blockade on in vitro renin release , tissue renin content and tissue cyclic_AMP content in the rat .
7011235	0	dopamine	32,40	renin	44,49	dopamine	renin	MESH:D004298	403838(Tax:9615)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	-LSB- Effect of sub-pressor doses of dopamine on renin secretion in the anesthetized dog -RSB- .
7037817	0	dopamine	53,61	renin	100,105	dopamine	renin	MESH:D004298	5972	Chemical	Gene	receptors|amod|START_ENTITY inhibitor|nmod|receptors domperidone|appos|inhibitor Effect|nmod|domperidone Effect|nmod|aldosterone aldosterone|dep|END_ENTITY	Effect of domperidone , an extracerebral inhibitor of dopamine receptors , on thyrotropin , prolactin , renin , aldosterone , and 18-hydroxycorticosterone secretion in man .
11082482	0	dopamine	22,30	retinal_degeneration_slow	84,109	dopamine	retinal degeneration slow	MESH:D004298	19133(Tax:10090)	Chemical	Gene	metabolism|nmod|START_ENTITY END_ENTITY|nsubj|metabolism	Diurnal metabolism of dopamine in dystrophic_retinas of homozygous and heterozygous retinal_degeneration_slow -LRB- rds -RRB- mice .
9516406	0	dopamine	56,64	rhodopsin	43,52	dopamine	rhodopsin	MESH:D004298	6010	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of the phosphorylation state of rhodopsin by dopamine .
2498964	0	dopamine	33,41	selective_D-1_and_D-2	11,32	dopamine	selective D-1 and D-2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|amod|END_ENTITY	Effects of selective_D-1_and_D-2 dopamine antagonists on development of methamphetamine-induced behavioral sensitization .
3886407	0	dopamine	53,61	selective_D-1_and_D-2	138,159	dopamine	selective D-1 and D-2	MESH:D004298	28503	Chemical	Gene	agonist|compound|START_ENTITY responses|nmod|agonist responses|dep|interactions interactions|nmod|SCH_23390 SCH_23390|amod|END_ENTITY	Sniffing , rearing and locomotor responses to the D-1 dopamine agonist R-SK_F 38393 and to apomorphine : differential interactions with the selective_D-1_and_D-2 antagonists SCH_23390 and metoclopramide .
2962555	0	dopamine	32,40	specific_D-1_and_D-2	11,31	dopamine	specific D-1 and D-2	MESH:D004298	29484(Tax:10116)	Chemical	Gene	agonists|compound|START_ENTITY agonists|amod|END_ENTITY	Effects of specific_D-1_and_D-2 dopamine agonists -LRB- LY141865 and SKF-38393 -RRB- and pergolide on urinary output of rats .
114468	0	dopamine	77,85	thyrotropin-releasing_hormone	33,62	dopamine	thyrotropin-releasing hormone	MESH:D004298	25569(Tax:10116)	Chemical	Gene	influence|advcl|START_ENTITY influence|nmod|release release|nmod|prolactin prolactin|nmod|END_ENTITY	In vitro release of prolactin by thyrotropin-releasing_hormone : influence of dopamine , thyroxine , and cycloheximide .
1634191	0	dopamine	11,19	thyrotropin-releasing_hormone	38,67	dopamine	thyrotropin-releasing hormone	MESH:D004298	25569(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|release release|nmod|END_ENTITY	Effects of dopamine on the release of thyrotropin-releasing_hormone from the rat retina in vitro .
1680223	0	dopamine	12,20	thyrotropin-releasing_hormone	38,67	dopamine	thyrotropin-releasing hormone	MESH:D004298	25569(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|regulation regulation|nmod|END_ENTITY	The role of dopamine in regulation of thyrotropin-releasing_hormone in the striatum and nucleus accumbens of the rat .
1686587	0	dopamine	21,29	thyrotropin-releasing_hormone	66,95	dopamine	thyrotropin-releasing hormone	MESH:D004298	100346454(Tax:9986)	Chemical	Gene	D1|amod|START_ENTITY D1|nmod|model model|nmod|END_ENTITY	Interactions between dopamine D1 and D2 receptors in the model of thyrotropin-releasing_hormone -LRB- TRH -RRB- - induced behaviour in rabbits .
1707722	0	dopamine	75,83	thyrotropin-releasing_hormone	27,56	dopamine	thyrotropin-releasing hormone	MESH:D004298	25569(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY enhances|dobj|release enhances|nsubj|administration administration|nmod|END_ENTITY	Systemic administration of thyrotropin-releasing_hormone enhances striatal dopamine release in vivo .
20152128	0	dopamine	60,68	thyrotropin-releasing_hormone	107,136	dopamine	thyrotropin-releasing hormone	MESH:D004298	25569(Tax:10116)	Chemical	Gene	neurons|compound|START_ENTITY oscillations|nmod|neurons oscillations|dep|switch switch|nmod|discharge discharge|nmod|END_ENTITY	Synchronized network oscillations in rat tuberoinfundibular dopamine neurons : switch to tonic discharge by thyrotropin-releasing_hormone .
2119294	0	dopamine	222,230	thyrotropin-releasing_hormone	55,84	dopamine	thyrotropin-releasing hormone	MESH:D004298	25569(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY comparison|dep|effects comparison|nmod|actions actions|nmod|END_ENTITY	A comparison of the concentration-dependent actions of thyrotropin-releasing_hormone , angiotensin_II , bradykinin , and Lys-bradykinin on cytosolic free calcium dynamics in rat anterior pituitary cells : selective effects of dopamine .
3035515	0	dopamine	14,22	thyrotropin-releasing_hormone	36,65	dopamine	thyrotropin-releasing hormone	MESH:D004298	25569(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY Modulation|nmod|receptors Modulation|nmod|END_ENTITY	Modulation of dopamine receptors by thyrotropin-releasing_hormone in the rat brain .
3090397	0	dopamine	53,61	thyrotropin-releasing_hormone	76,105	dopamine	thyrotropin-releasing hormone	MESH:D004298	25569(Tax:10116)	Chemical	Gene	antagonism|compound|START_ENTITY antagonism|nmod|END_ENTITY	A comparison of the effects of suckling or transient dopamine antagonism on thyrotropin-releasing_hormone and suckling induced prolactin release in lactating rats .
3129665	0	dopamine	47,55	thyrotropin-releasing_hormone	113,142	dopamine	thyrotropin-releasing hormone	MESH:D004298	25569(Tax:10116)	Chemical	Gene	regulation|amod|START_ENTITY removal|nmod|regulation potentiates|nsubj|removal potentiates|dobj|action action|nmod|END_ENTITY	Mechanism -LRB- s -RRB- by which the transient removal of dopamine regulation potentiates the prolactin-releasing action of thyrotropin-releasing_hormone .
6135480	0	dopamine	13,21	thyrotropin-releasing_hormone	112,141	dopamine	thyrotropin-releasing hormone	MESH:D004298	25569(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY Influence|nmod|receptor agonists|nsubj|Influence agonists|nmod|secretion secretion|acl|induced induced|nmod|administration administration|nmod|END_ENTITY	Influence of dopamine receptor agonists on gastric_acid secretion induced by intraventricular administration of thyrotropin-releasing_hormone in the perfused stomach of anaesthetized rats .
6436160	2	dopamine	127,135	thyrotropin-releasing_hormone	85,114	dopamine	thyrotropin-releasing hormone	MESH:D004298	7200	Chemical	Gene	infusion|compound|START_ENTITY END_ENTITY|nmod|infusion	Restoration of the prolactin response to thyrotropin-releasing_hormone by low-dose dopamine infusion in women with pathological hyperprolactinemia .
7906871	0	dopamine	12,20	thyrotropin-releasing_hormone	49,78	dopamine	thyrotropin-releasing hormone	MESH:D004298	25569(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY role|nmod|receptors role|nmod|release release|nmod|END_ENTITY	The role of dopamine receptors in the release of thyrotropin-releasing_hormone from the rat striatum and nucleus accumbens : an in vitro study .
8234033	0	dopamine	62,70	thyrotropin-releasing_hormone	11,40	dopamine	thyrotropin-releasing hormone	MESH:D004298	25569(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY Effects|nmod|release Effects|nmod|END_ENTITY	Effects of thyrotropin-releasing_hormone and phorbol_ester on dopamine release from dispersed rat tuberoinfundibular dopaminergic neurons .
8559275	0	dopamine	176,184	thyrotropin-releasing_hormone	126,155	dopamine	thyrotropin-releasing hormone	MESH:D004298	25569(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY stimulates|dobj|release stimulates|nsubj|analogue analogue|amod|END_ENTITY	Semicircadian rhythm of dopamine release in the mediobasal_hypothalamus in awake rats during pseudopregnancy : evidence that a thyrotropin-releasing_hormone analogue stimulates dopamine release and thereby inhibits prolactin secretion .
8559275	0	dopamine	24,32	thyrotropin-releasing_hormone	126,155	dopamine	thyrotropin-releasing hormone	MESH:D004298	25569(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY rhythm|nmod|release rhythm|dep|evidence evidence|dep|stimulates stimulates|nsubj|analogue analogue|amod|END_ENTITY	Semicircadian rhythm of dopamine release in the mediobasal_hypothalamus in awake rats during pseudopregnancy : evidence that a thyrotropin-releasing_hormone analogue stimulates dopamine release and thereby inhibits prolactin secretion .
9354030	0	dopamine	209,217	thyrotropin-releasing_hormone	23,52	dopamine	thyrotropin-releasing hormone	MESH:D004298	25569(Tax:10116)	Chemical	Gene	combination|amod|START_ENTITY effects|nmod|combination comparison|nmod|effects Effects|dep|comparison Effects|appos|analogue analogue|amod|END_ENTITY	Effects of YM-14673 , a thyrotropin-releasing_hormone analogue , injected into the shell and the core of the nucleus accumbens on production of repetitive jaw_movements in rats : comparison with the effects of a dopamine D1 and D2 receptor agonist combination .
9438522	0	dopamine	15,23	thyrotropin-releasing_hormone	70,99	dopamine	thyrotropin-releasing hormone	MESH:D004298	25569(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY Involvement|nmod|receptors Involvement|nmod|effect effect|nmod|TA-0910 TA-0910|amod|END_ENTITY	Involvement of dopamine D2 receptors in the suppressive effect of the thyrotropin-releasing_hormone analog TA-0910 on alcohol intake in alcohol-preferring rats .
9608876	0	dopamine	98,106	thyrotropin-releasing_hormone	49,78	dopamine	thyrotropin-releasing hormone	MESH:D004298	25569(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|taltirelin_hydrate taltirelin_hydrate|appos|analog analog|amod|END_ENTITY	Effects of taltirelin_hydrate -LRB- TA-0910 -RRB- , a novel thyrotropin-releasing_hormone analog , on in vivo dopamine release and turnover in rat brain .
21521749	0	dopamine	79,87	transforming_growth_factor-b1	17,46	dopamine	transforming growth factor-b1	MESH:D004298	7040	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Active and total transforming_growth_factor-b1 are differentially regulated by dopamine and estradiol in the pituitary .
6097187	0	dopamine	26,34	tyrosinase	48,58	dopamine	tyrosinase	MESH:D004298	7299	Chemical	Gene	oxidation|amod|START_ENTITY oxidation|nmod|END_ENTITY	Chemical intermediates in dopamine oxidation by tyrosinase , and kinetic studies of the process .
10358021	0	dopamine	71,79	tyrosine_hydroxylase	38,58	dopamine	tyrosine hydroxylase	MESH:D004298	38746(Tax:7227)	Chemical	Gene	phosphorylation|amod|START_ENTITY END_ENTITY|nmod|phosphorylation	Differential regulation of Drosophila tyrosine_hydroxylase isoforms by dopamine binding and cAMP-dependent phosphorylation .
10579240	0	dopamine	8,16	tyrosine_hydroxylase	50,70	dopamine	tyrosine hydroxylase	MESH:D004298	25085(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY Role|nmod|receptors Role|nmod|mRNA mRNA|amod|END_ENTITY	Role of dopamine receptors and the changes of the tyrosine_hydroxylase mRNA in acupuncture analgesia in rats .
10620706	0	dopamine	61,69	tyrosine_hydroxylase	116,136	dopamine	tyrosine hydroxylase	MESH:D004298	7054	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|activity activity|nmod|type type|compound|END_ENTITY	Positive charge intrinsic to Arg -LRB- 37 -RRB- - Arg -LRB- 38 -RRB- is critical for dopamine inhibition of the catalytic activity of human tyrosine_hydroxylase type 1 .
10758337	0	dopamine	104,112	tyrosine_hydroxylase	23,43	dopamine	tyrosine hydroxylase	MESH:D004298	25085(Tax:10116)	Chemical	Gene	down-regulated|nmod|START_ENTITY down-regulated|nsubj|expression expression|nmod|END_ENTITY	In vitro expression of tyrosine_hydroxylase by a subpopulation of rat melanotrophs is down-regulated by dopamine .
10925142	0	dopamine	70,78	tyrosine_hydroxylase	17,37	dopamine	tyrosine hydroxylase	MESH:D004298	7054	Chemical	Gene	START_ENTITY|nsubj|Up-regulation Up-regulation|nmod|mRNA mRNA|amod|END_ENTITY	Up-regulation of tyrosine_hydroxylase mRNA in a sub-population of A10 dopamine neurons in Parkinson 's _ disease .
11207940	0	dopamine	121,129	tyrosine_hydroxylase	46,66	dopamine	tyrosine hydroxylase	MESH:D004298	25085(Tax:10116)	Chemical	Gene	concentrations|compound|START_ENTITY TH|dobj|concentrations TH|nsubj|Effects Effects|nmod|END_ENTITY	Effects of chronic bromocriptine treatment on tyrosine_hydroxylase -LRB- TH -RRB- mRNA expression , TH activity and median eminence dopamine concentrations in ageing rats .
11334998	0	dopamine	39,47	tyrosine_hydroxylase	86,106	dopamine	tyrosine hydroxylase	MESH:D004298	25085(Tax:10116)	Chemical	Gene	formation|nmod|START_ENTITY induction|nmod|formation induction|nmod|expression expression|amod|END_ENTITY	Parallel induction of the formation of dopamine and its metabolites with induction of tyrosine_hydroxylase expression in foetal rat and human cerebral cortical cells by brain-derived_neurotrophic_factor and glial-cell_derived_neurotrophic_factor .
12358737	0	dopamine	80,88	tyrosine_hydroxylase	28,48	dopamine	tyrosine hydroxylase	MESH:D004298	25085(Tax:10116)	Chemical	Gene	reduces|nmod|START_ENTITY reduces|nsubj|mutation mutation|nmod|END_ENTITY	A site-specific mutation of tyrosine_hydroxylase reduces feedback inhibition by dopamine in genetically modified cells grafted in parkinsonian rats .
12429192	0	dopamine	88,96	tyrosine_hydroxylase	41,61	dopamine	tyrosine hydroxylase	MESH:D004298	25085(Tax:10116)	Chemical	Gene	neurons|compound|START_ENTITY END_ENTITY|nmod|neurons	Aberrant sprouting and downregulation of tyrosine_hydroxylase in lesioned nigrostriatal dopamine neurons induced by long-lasting overexpression of glial_cell_line_derived_neurotrophic_factor in the striatum by lentiviral gene transfer .
1363326	0	dopamine	124,132	tyrosine_hydroxylase	66,86	dopamine	tyrosine hydroxylase	MESH:D004298	25085(Tax:10116)	Chemical	Gene	neurons|compound|START_ENTITY gene|nmod|neurons gene|amod|END_ENTITY	Muscle-derived differentiation factor increases expression of the tyrosine_hydroxylase gene and enzyme activity in cultured dopamine neurons from the rat midbrain .
1365463	0	dopamine	12,20	tyrosine_hydroxylase	69,89	dopamine	tyrosine hydroxylase	MESH:D004298	25085(Tax:10116)	Chemical	Gene	START_ENTITY|dep|controlling controlling|dobj|activity activity|amod|END_ENTITY	Presynaptic dopamine autoreceptors and second messengers controlling tyrosine_hydroxylase activity in rat brain .
15269253	0	dopamine	188,196	tyrosine_hydroxylase	139,159	dopamine	tyrosine hydroxylase	MESH:D004298	25085(Tax:10116)	Chemical	Gene	system|compound|START_ENTITY END_ENTITY|nmod|system	Overexpression of glial_cell_line-derived_neurotrophic_factor using a lentiviral vector induces time - and dose-dependent downregulation of tyrosine_hydroxylase in the intact nigrostriatal dopamine system .
16555063	0	dopamine	134,142	tyrosine_hydroxylase	49,69	dopamine	tyrosine hydroxylase	MESH:D004298	25085(Tax:10116)	Chemical	Gene	pathways|compound|START_ENTITY Effect|nmod|pathways Effect|nmod|self-administration self-administration|nmod|levels levels|compound|END_ENTITY	Effect of methamphetamine self-administration on tyrosine_hydroxylase and dopamine_transporter levels in mesolimbic and nigrostriatal dopamine pathways of the rat .
1674981	0	dopamine	24,32	tyrosine_hydroxylase	72,92	dopamine	tyrosine hydroxylase	MESH:D004298	25085(Tax:10116)	Chemical	Gene	neurons|compound|START_ENTITY neurons|dep|effect effect|nmod|steroids steroids|nmod|END_ENTITY	Incertohypothalamic A13 dopamine neurons : effect of gonadal steroids on tyrosine_hydroxylase .
1979431	0	dopamine	62,70	tyrosine_hydroxylase	10,30	dopamine	tyrosine hydroxylase	MESH:D004298	7054	Chemical	Gene	neurons|compound|START_ENTITY RNA|nmod|neurons RNA|amod|END_ENTITY	Decreased tyrosine_hydroxylase messenger RNA in the surviving dopamine neurons of the substantia nigra in Parkinson 's _ disease : an in situ hybridization study .
20716859	0	dopamine	21,29	tyrosine_hydroxylase	146,166	dopamine	tyrosine hydroxylase	MESH:D004298	21823(Tax:10090)	Chemical	Gene	research|nmod|START_ENTITY research|dep|regulation regulation|nmod|transmission transmission|nmod|protein protein|amod|END_ENTITY	Advanced research on dopamine signaling to develop drugs for the treatment of mental_disorders : regulation of dopaminergic neural transmission by tyrosine_hydroxylase protein at nerve terminals .
21514317	0	dopamine	105,113	tyrosine_hydroxylase	40,60	dopamine	tyrosine hydroxylase	MESH:D004298	7054	Chemical	Gene	3,4-dihydroxyphenylacetaldehyde|appos|START_ENTITY END_ENTITY|nmod|3,4-dihydroxyphenylacetaldehyde	Inhibition and covalent modification of tyrosine_hydroxylase by 3,4-dihydroxyphenylacetaldehyde , a toxic dopamine metabolite .
22027820	0	dopamine	27,35	tyrosine_hydroxylase	58,78	dopamine	tyrosine hydroxylase	MESH:D004298	21823(Tax:10090)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|gene gene|amod|END_ENTITY	Compensatory regulation of dopamine after ablation of the tyrosine_hydroxylase gene in the nigrostriatal projection .
2571111	0	dopamine	47,55	tyrosine_hydroxylase	83,103	dopamine	tyrosine hydroxylase	MESH:D004298	25085(Tax:10116)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Involvement of adenylate cyclase inhibition in dopamine autoreceptor regulation of tyrosine_hydroxylase in rat nucleus accumbens .
2571152	0	dopamine	101,109	tyrosine_hydroxylase	31,51	dopamine	tyrosine hydroxylase	MESH:D004298	7054	Chemical	Gene	cells|amod|START_ENTITY release|nmod|cells transfer|dep|release transfer|nmod|cDNA cDNA|compound|END_ENTITY	Retroviral transfer of a human tyrosine_hydroxylase cDNA in various cell lines : regulated release of dopamine in mouse anterior pituitary AtT-20 cells .
26777664	0	dopamine	50,58	tyrosine_hydroxylase	98,118	dopamine	tyrosine hydroxylase	MESH:D004298	25085(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY reduces|dobj|activity reduces|advcl|affecting affecting|dobj|expression expression|amod|END_ENTITY	Long-term controlled GDNF over-expression reduces dopamine transporter activity without affecting tyrosine_hydroxylase expression in the rat mesostriatal system .
31232	0	dopamine	43,51	tyrosine_hydroxylase	152,172	dopamine	tyrosine hydroxylase	MESH:D004298	25085(Tax:10116)	Chemical	Gene	neurons|compound|START_ENTITY sprouting|nmod|neurons sprouting|dep|evidence evidence|nmod|changes changes|nmod|activity activity|nmod|END_ENTITY	Collateral sprouting in central mesolimbic dopamine neurons : biochemical and immunocytochemical evidence of changes in the activity and distrubution of tyrosine_hydroxylase in terminal fields and in cell bodies of A10 neurons .
41189	0	dopamine	43,51	tyrosine_hydroxylase	81,101	dopamine	tyrosine hydroxylase	MESH:D004298	25085(Tax:10116)	Chemical	Gene	synthesis|compound|START_ENTITY accelerates|dobj|synthesis accelerates|advcl|activating activating|dobj|END_ENTITY	Foot-shock stress accelerates non-striatal dopamine synthesis without activating tyrosine_hydroxylase .
6124255	0	dopamine	79,87	tyrosine_hydroxylase	100,120	dopamine	tyrosine hydroxylase	MESH:D004298	21823(Tax:10090)	Chemical	Gene	agonists|amod|START_ENTITY agonists|nmod|activity activity|amod|END_ENTITY	Mouse_neuroblastoma clone N1E-115 : a suitable model for studying the action of dopamine agonists of tyrosine_hydroxylase activity .
6139733	0	dopamine	80,88	tyrosine_hydroxylase	39,59	dopamine	tyrosine hydroxylase	MESH:D004298	25085(Tax:10116)	Chemical	Gene	neurons|compound|START_ENTITY activity|nmod|neurons activity|amod|END_ENTITY	Alpha 2-adrenergic receptors influence tyrosine_hydroxylase activity in retinal dopamine neurons .
7784896	0	dopamine	21,29	tyrosine_hydroxylase	102,122	dopamine	tyrosine hydroxylase	MESH:D004298	721137(Tax:9544)	Chemical	Gene	neurons|compound|START_ENTITY Fate|nmod|neurons transplanted|nsubj|Fate transplanted|nmod|model model|nmod|disease disease|dep|-RSB- -RSB-|amod|END_ENTITY	-LSB- Fate of human fetal dopamine neurons transplanted into rhesus_monkey model of Parkinson 's _ disease : a tyrosine_hydroxylase immunocytochemical study -RSB- .
7912404	0	dopamine	61,69	tyrosine_hydroxylase	27,47	dopamine	tyrosine hydroxylase	MESH:D004298	25085(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Differential expression of tyrosine_hydroxylase and membrane dopamine transporter genes in subpopulations of dopaminergic neurons of the rat mesencephalon .
8097033	0	dopamine	24,32	tyrosine_hydroxylase	96,116	dopamine	tyrosine hydroxylase	MESH:D004298	7054	Chemical	Gene	mechanism|nmod|START_ENTITY biosynthesis|nsubj|mechanism biosynthesis|advcl|carrying carrying|dobj|gene gene|compound|END_ENTITY	Regulatory mechanism of dopamine biosynthesis in the striatum of transgenic_mice carrying human tyrosine_hydroxylase gene .
8098283	0	dopamine	146,154	tyrosine_hydroxylase	68,88	dopamine	tyrosine hydroxylase	MESH:D004298	25085(Tax:10116)	Chemical	Gene	neurons|compound|START_ENTITY reduction|nmod|neurons reduction|nmod|stores stores|amod|END_ENTITY	The vigilance-promoting drug modafinil counteracts the reduction of tyrosine_hydroxylase immunoreactivity and of dopamine stores in nigrostriatal dopamine neurons in the male rat after a partial transection of the dopamine pathway .
8098283	0	dopamine	214,222	tyrosine_hydroxylase	68,88	dopamine	tyrosine hydroxylase	MESH:D004298	25085(Tax:10116)	Chemical	Gene	pathway|amod|START_ENTITY transection|nmod|pathway counteracts|nmod|transection counteracts|dobj|reduction reduction|nmod|stores stores|amod|END_ENTITY	The vigilance-promoting drug modafinil counteracts the reduction of tyrosine_hydroxylase immunoreactivity and of dopamine stores in nigrostriatal dopamine neurons in the male rat after a partial transection of the dopamine pathway .
8821486	0	dopamine	73,81	tyrosine_hydroxylase	17,37	dopamine	tyrosine hydroxylase	MESH:D004298	21823(Tax:10090)	Chemical	Gene	differentiation|amod|START_ENTITY decarboxylase|nmod|differentiation decarboxylase|amod|END_ENTITY	Co-expression of tyrosine_hydroxylase and glutamic_acid decarboxylase in dopamine differentiation factor-treated striatal neurons in culture .
8858935	0	dopamine	135,143	tyrosine_hydroxylase	79,99	dopamine	tyrosine hydroxylase	MESH:D004298	25085(Tax:10116)	Chemical	Gene	neurons|compound|START_ENTITY activity|nmod|neurons activity|compound|END_ENTITY	Acidic_fibroblast_growth_factor and catecholamines synergistically up-regulate tyrosine_hydroxylase activity in developing and damaged dopamine neurons in culture .
8930333	0	dopamine	79,87	tyrosine_hydroxylase	130,150	dopamine	tyrosine hydroxylase	MESH:D004298	7054	Chemical	Gene	system|compound|START_ENTITY regions|nmod|system immunoreactivity|nmod|regions associated|nsubjpass|immunoreactivity associated|nmod|reappearance reappearance|nmod|immunoreactivity immunoreactivity|amod|END_ENTITY	Altered Fos-like immunoreactivity in terminal regions of the mesotelencephalic dopamine system is associated with reappearance of tyrosine_hydroxylase immunoreactivity at the sites of focal 6-hydroxydopamine lesions in the nucleus accumbens .
8963658	0	dopamine	169,177	tyrosine_hydroxylase	64,84	dopamine	tyrosine hydroxylase	MESH:D004298	25085(Tax:10116)	Chemical	Gene	systems|compound|START_ENTITY elevated|nmod|systems elevated|dobj|mRNA mRNA|amod|END_ENTITY	Rats bred for enhanced apomorphine susceptibility have elevated tyrosine_hydroxylase mRNA and dopamine D2-receptor binding sites in nigrostriatal and tuberoinfundibular dopamine systems .
9169516	0	dopamine	9,17	tyrosine_hydroxylase	100,120	dopamine	tyrosine hydroxylase	MESH:D004298	25085(Tax:10116)	Chemical	Gene	subpopulations|compound|START_ENTITY exhibit|nsubj|subpopulations exhibit|dobj|rates rates|compound|END_ENTITY	Neuronal dopamine subpopulations maintained in hypothalamic slice explant cultures exhibit distinct tyrosine_hydroxylase mRNA turnover rates .
9224801	0	dopamine	11,19	tyrosine_hydroxylase	48,68	dopamine	tyrosine hydroxylase	MESH:D004298	7054	Chemical	Gene	START_ENTITY|nmod|type type|compound|END_ENTITY	Effects of dopamine on N-terminus-deleted human tyrosine_hydroxylase type 1 expressed in Escherichia_coli .
4027572	0	dopamine	51,59	vasopressin	15,26	dopamine	vasopressin	MESH:D004298	551	Chemical	Gene	system|compound|START_ENTITY END_ENTITY|nmod|system	Interaction of vasopressin with the nigro-striatal dopamine system : site and mechanism of action .
23352937	0	dopamine	26,34	vitamin_D_receptor	4,22	dopamine	vitamin D receptor	MESH:D004298	7421	Chemical	Gene	neurons|amod|START_ENTITY END_ENTITY|nmod|neurons	The vitamin_D_receptor in dopamine neurons ; its presence in human substantia nigra and its ontogenesis in rat midbrain .
12470865	0	dopamine	89,97	zif268	13,19	dopamine	zif268	MESH:D004298	1958	Chemical	Gene	role|nmod|START_ENTITY expression|dep|role expression|appos|END_ENTITY	Basal EGR-1 -LRB- zif268 , NGFI-A , Krox-24 -RRB- expression in developing striatal patches : role of dopamine and glutamate .
1491805	0	dopamine	4,12	zif268	100,106	dopamine	zif268	MESH:D004298	24330(Tax:10116)	Chemical	Gene	SCH-23390|compound|START_ENTITY decreases|nsubj|SCH-23390 decreases|dobj|levels levels|nmod|END_ENTITY	The dopamine D1 receptor antagonist SCH-23390 decreases the mRNA levels of the transcription factor zif268 -LRB- krox-24 -RRB- in adult rat intact striatum -- an in situ hybridization study .
8708002	0	dopamine	3,11	zif268	43,49	dopamine	zif268	MESH:D004298	24330(Tax:10116)	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	D1 dopamine receptor-mediated induction of zif268 and c-fos in the dopamine-depleted striatum : differential regulation and independence from NMDA receptors .
7913299	0	dopexamine	20,30	DA-1	34,38	dopexamine	DA-1	MESH:C046318	294269(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Salutary effects of dopexamine , a DA-1 and beta-2 agonist , on free radical-induced toxicity in anesthetized rats .
2871852	0	dopexamine	43,53	beta_2-adrenoceptor	61,80	dopexamine	beta 2-adrenoceptor	MESH:C046318	154	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|END_ENTITY	The haemodynamic and myocardial effects of dopexamine : a new beta_2-adrenoceptor and dopaminergic agonist .
15138671	0	dopexamine	11,21	prolactin	49,58	dopexamine	prolactin	MESH:C046318	5617	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|concentrations concentrations|compound|END_ENTITY	Effects of dopexamine , dobutamine or dopamine on prolactin and thyreotropin serum concentrations in high-risk surgical patients .
18834580	0	dorzolamide	39,50	X-linked_retinoschisis	54,76	dorzolamide	X-linked retinoschisis	MESH:C062765	6247	Chemical	Gene	Relation|nmod|START_ENTITY Relation|nmod|END_ENTITY	Relation of response to treatment with dorzolamide in X-linked_retinoschisis to the mechanism of functional loss in retinoschisin .
26093313	0	dorzolamide	59,70	carbonic_anhydrase_II	91,112	dorzolamide	carbonic anhydrase II	MESH:C062765	760	Chemical	Gene	studies|nmod|START_ENTITY studies|nmod|END_ENTITY	Spectroscopic and molecular modeling studies on binding of dorzolamide to bovine and human carbonic_anhydrase_II .
18834580	0	dorzolamide	39,50	retinoschisin	116,129	dorzolamide	retinoschisin	MESH:C062765	6247	Chemical	Gene	Relation|nmod|START_ENTITY Relation|nmod|END_ENTITY	Relation of response to treatment with dorzolamide in X-linked_retinoschisis to the mechanism of functional loss in retinoschisin .
10048009	0	dorzolamide_hydrochloride	180,205	carbonic_anhydrase_II	148,169	dorzolamide hydrochloride	carbonic anhydrase II	MESH:C062765	760	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Postoperative behavior of intraocular pressure after posterior Nd : YAG laser capsulotomy -- critical evaluation in preventive administration of local carbonic_anhydrase_II inhibitor dorzolamide_hydrochloride -LRB- Trusopt -RRB- -RSB- .
19616522	0	downregulates	55,68	matrix_metalloproteinase-9	69,95	downregulates	matrix metalloproteinase-9	null	17395(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|expression expression|amod|END_ENTITY	A small-molecule metastasis inhibitor , norcantharidin , downregulates matrix_metalloproteinase-9 expression by inhibiting Sp1 transcriptional activity in colorectal_cancer cells .
2565917	0	doxazosin	35,44	Alpha-1	0,7	doxazosin	Alpha-1	MESH:D017292	146	Chemical	Gene	blockade|nmod|START_ENTITY blockade|amod|END_ENTITY	Alpha-1 adrenoceptor blockade with doxazosin in hypertension : effects on blood pressure and lipoproteins .
16680063	0	doxazosin	10,19	C-reactive_protein	23,41	doxazosin	C-reactive protein	MESH:D017292	1401	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|amod|END_ENTITY	Effect of doxazosin on C-reactive_protein plasma levels and on nitric_oxide in patients with hypertension .
15968318	0	doxazosin	22,31	PC-3	92,96	doxazosin	PC-3	MESH:D017292	18548(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	-LSB- Inhibitory effect of doxazosin on the growth of transplanted tumor of prostate_cancer cell PC-3 in nude_mice -RSB- .
7505224	0	doxazosin	43,52	alpha-1	27,34	doxazosin	alpha-1	MESH:D017292	146	Chemical	Gene	START_ENTITY|nsubj|Efficacy Efficacy|nmod|blocker blocker|amod|END_ENTITY	Efficacy and safety of the alpha-1 blocker doxazosin in the treatment of benign_prostatic_hyperplasia .
22135033	0	doxazosin	10,19	eNOS	37,41	doxazosin	eNOS	MESH:D017292	24600(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of doxazosin on expression of eNOS in rat kidney in the presence of partial bladder_outlet_obstruction .
14517769	0	doxazosin	10,19	insulin	23,30	doxazosin	insulin	MESH:D017292	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|resistance resistance|compound|END_ENTITY	Effect of doxazosin on insulin resistance in hypertensive patients with obesity .
12834181	0	doxercalciferol	10,25	PTH	56,59	doxercalciferol	PTH	MESH:C042533	5741	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of doxercalciferol -LRB- 1alpha-hydroxyvitamin_D2 -RRB- on PTH , bone turnover and bone mineral density in a hemodialysis patient with persistent secondary_hyperparathyroidism post parathyroidectomy .
21169421	0	doxercalciferol	71,86	Pth	22,25	doxercalciferol	Pth	MESH:C042533	19226(Tax:10090)	Chemical	Gene	prohormones|amod|START_ENTITY expression|nmod|prohormones expression|compound|END_ENTITY	Direct suppression of Pth gene expression by the vitamin_D prohormones doxercalciferol and calcidiol requires the vitamin_D_receptor .
21169421	0	doxercalciferol	71,86	vitamin_D_receptor	114,132	doxercalciferol	vitamin D receptor	MESH:C042533	22337(Tax:10090)	Chemical	Gene	prohormones|amod|START_ENTITY expression|nmod|prohormones suppression|nmod|expression requires|nsubj|suppression requires|dobj|END_ENTITY	Direct suppression of Pth gene expression by the vitamin_D prohormones doxercalciferol and calcidiol requires the vitamin_D_receptor .
15756433	0	doxifluridine	60,73	Thymidine_phosphorylase	0,23	doxifluridine	Thymidine phosphorylase	MESH:C025034	1890	Chemical	Gene	START_ENTITY|nsubj|expression expression|amod|END_ENTITY	Thymidine_phosphorylase expression and efficacy of adjuvant doxifluridine in advanced colorectal_cancer patients .
19147539	0	doxorubicin	15,26	ABCB8	0,5	doxorubicin	ABCB8	MESH:D004317	11194	Chemical	Gene	resistance|compound|START_ENTITY mediates|dobj|resistance mediates|nsubj|END_ENTITY	ABCB8 mediates doxorubicin resistance in melanoma cells by protecting the mitochondrial genome .
23553841	0	doxorubicin	114,125	BAG-1	22,27	doxorubicin	BAG-1	MESH:D004317	573	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	Overexpressed nuclear BAG-1 in human hepatocellular_carcinoma is associated with poor prognosis and resistance to doxorubicin .
22203755	0	doxorubicin	165,176	BRCA1	194,199	doxorubicin	BRCA1	MESH:D004317	672	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|mutations mutations|compound|END_ENTITY	Phase II , open-label , randomized , multicenter study comparing the efficacy and safety of olaparib , a poly _ -LRB- ADP-ribose -RRB- polymerase inhibitor , and pegylated liposomal doxorubicin in patients with BRCA1 or BRCA2 mutations and recurrent ovarian_cancer .
1544596	0	doxorubicin	49,60	Basic_fibroblast_growth_factor	0,30	doxorubicin	Basic fibroblast growth factor	MESH:D004317	54250(Tax:10116)	Chemical	Gene	injury|amod|START_ENTITY END_ENTITY|nmod|injury	Basic_fibroblast_growth_factor in retardation of doxorubicin extravasation injury .
17227902	0	doxorubicin	64,75	CA125	17,22	doxorubicin	CA125	MESH:D004317	94025	Chemical	Gene	treatment|nmod|START_ENTITY END_ENTITY|nmod|treatment	Early changes in CA125 after treatment with pegylated liposomal doxorubicin or topotecan do not always reflect best response in recurrent ovarian_cancer patients .
17227902	1	doxorubicin	312,323	CA125	200,205	doxorubicin	CA125	MESH:D004317	94025	Chemical	Gene	treated|nmod|START_ENTITY ovarian_cancer|acl|treated patients|nmod|ovarian_cancer response|nmod|patients relative|nmod|response examine|advmod|relative examine|nmod|END_ENTITY	PURPOSE : To examine early changes in CA125 relative to objective response in patients with recurrent ovarian_cancer treated with pegylated liposomal doxorubicin -LRB- PLD -RRB- or topotecan and to compare the CA125 trends between the two chemotherapeutics .
26998164	0	doxorubicin	95,106	CD38	10,14	doxorubicin	CD38	MESH:D004317	952	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of CD38 on the multidrug resistance of human chronic_myelogenous_leukemia K562 cells to doxorubicin .
16326096	0	doxorubicin	35,46	CD99	10,14	doxorubicin	CD99	MESH:D004317	4267	Chemical	Gene	association|nmod|START_ENTITY END_ENTITY|nmod|association	Targeting CD99 in association with doxorubicin : an effective combined treatment for Ewing 's _ sarcoma .
25874485	0	doxorubicin	91,102	CHMP4B	5,11	doxorubicin	CHMP4B	MESH:D004317	128866	Chemical	Gene	associated|xcomp|START_ENTITY associated|nsubjpass|expression expression|compound|END_ENTITY	High CHMP4B expression is associated with accelerated cell proliferation and resistance to doxorubicin in hepatocellular_carcinoma .
25874485	0	doxorubicin	91,102	CHMP4B	5,11	doxorubicin	CHMP4B	MESH:D004317	128866	Chemical	Gene	associated|xcomp|START_ENTITY associated|nsubjpass|expression expression|compound|END_ENTITY	High CHMP4B expression is associated with accelerated cell proliferation and resistance to doxorubicin in hepatocellular_carcinoma .
18343487	0	doxorubicin	158,169	Ca125	19,24	doxorubicin	Ca125	MESH:D004317	94025	Chemical	Gene	gemcitabine|nmod|START_ENTITY trial|nmod|gemcitabine results|nmod|trial analysis|nmod|results role|dep|analysis role|nmod|criteria criteria|amod|END_ENTITY	Prognostic role of Ca125 response criteria and RECIST criteria : analysis of results from the MITO-3 phase III trial of gemcitabine versus pegylated liposomal doxorubicin in recurrent ovarian_cancer .
19379302	0	doxorubicin	79,90	Cardiac_troponin_I	0,18	doxorubicin	Cardiac troponin I	MESH:D004317	7137	Chemical	Gene	patients|nmod|START_ENTITY END_ENTITY|nmod|patients	Cardiac_troponin_I in canine patients with lymphoma and osteosarcoma receiving doxorubicin : comparison with clinical heart_disease in a retrospective analysis .
12878867	0	doxorubicin	55,66	DR4	20,23	doxorubicin	DR4	MESH:D004317	8797	Chemical	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	An antibody against DR4 -LRB- TRAIL-R1 -RRB- in combination with doxorubicin selectively kills malignant but not normal prostate cells .
21419175	0	doxorubicin	28,39	ERp29	0,5	doxorubicin	ERp29	MESH:D004317	67397(Tax:10090)	Chemical	Gene	regulates|advcl|START_ENTITY regulates|nsubj|END_ENTITY	ERp29 regulates response to doxorubicin by a PERK-mediated mechanism .
1874574	0	doxorubicin	46,57	Epidermal_growth_factor	0,23	doxorubicin	Epidermal growth factor	MESH:D004317	1950	Chemical	Gene	reduces|nmod|START_ENTITY reduces|nsubj|END_ENTITY	Epidermal_growth_factor reduces resistance to doxorubicin .
22128155	0	doxorubicin	91,102	FOXO3a	19,25	doxorubicin	FOXO3a	MESH:D004317	2309	Chemical	Gene	promotes|nmod|START_ENTITY promotes|nsubj|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation of FOXO3a on Ser-7 by p38 promotes its nuclear localization in response to doxorubicin .
25871400	0	doxorubicin	22,33	FOXO3a	135,141	doxorubicin	FOXO3a	MESH:D004317	2309	Chemical	Gene	resistance|compound|START_ENTITY decreases|dobj|resistance decreases|advcl|inhibiting inhibiting|dobj|association association|nmod|activation activation|amod|END_ENTITY	Salinomycin decreases doxorubicin resistance in hepatocellular_carcinoma cells by inhibiting the b-catenin/TCF complex association via FOXO3a activation .
26175858	0	doxorubicin	49,60	G15	0,3	doxorubicin	G15	MESH:D004317	10181	Chemical	Gene	sensitizes|xcomp|START_ENTITY sensitizes|nsubj|END_ENTITY	G15 sensitizes epithelial breast cancer cells to doxorubicin by preventing epithelial-mesenchymal transition through inhibition of GPR30 .
12018567	0	doxorubicin	75,86	GM-CSF	14,20	doxorubicin	GM-CSF	MESH:D004317	116630(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of GM-CSF -LRB- granulocyte macrophage colony stimulating factor -RRB- on doxorubicin induced tissue necrosis and wound healing .
18928619	0	doxorubicin	58,69	GM-CSF	116,122	doxorubicin	GM-CSF	MESH:D004317	1437	Chemical	Gene	induced|nmod|START_ENTITY induced|nmod|transcriptional transcriptional|acl|targeting targeting|nmod|expression expression|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Regulatory effect of Egr-1 promoter sequences induced by doxorubicin in transcriptional targeting on expression of GM-CSF gene -RSB- .
19379579	0	doxorubicin	11,22	GM-CSF	31,37	doxorubicin	GM-CSF	MESH:D004317	12981(Tax:10090)	Chemical	Gene	START_ENTITY|acl|induced induced|dobj|expression expression|amod|END_ENTITY	-LSB- Effect of doxorubicin induced GM-CSF gene expression regulated by Egr-1 promoter on recovery of hematopoietic function in bearing-melanoma mice -RSB- .
7536434	0	doxorubicin	59,70	GM-CSF	166,172	doxorubicin	GM-CSF	MESH:D004317	1437	Chemical	Gene	colony|amod|START_ENTITY sarcoma|nmod|colony sarcoma|dep|END_ENTITY	Treatment of poor prognosis epidemic Kaposi 's _ sarcoma with doxorubicin , bleomycin , vindesine and recombinant human granulocyte-monocyte colony stimulating factor -LRB- rh GM-CSF -RRB- .
7826903	0	doxorubicin	60,71	GM-CSF	183,189	doxorubicin	GM-CSF	MESH:D004317	1437	Chemical	Gene	cyclophosphamide|dep|START_ENTITY 5-fluorouracil|dep|cyclophosphamide FLAC|appos|5-fluorouracil study|nmod|FLAC study|appos|END_ENTITY	A dose intensity study of FLAC -LRB- 5-fluorouracil , leucovorin , doxorubicin , cyclophosphamide -RRB- chemotherapy and Escherichia_coli-derived granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- in advanced breast_cancer patients .
8630380	0	doxorubicin	61,72	GM-CSF	196,202	doxorubicin	GM-CSF	MESH:D004317	1437	Chemical	Gene	trial|nmod|START_ENTITY trial|nmod|protein protein|appos|END_ENTITY	Prospective , randomized trial of 5-fluorouracil , leucovorin , doxorubicin , and cyclophosphamide chemotherapy in combination with the interleukin-3 / granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- fusion protein -LRB- PIXY321 -RRB- versus GM-CSF in patients with advanced_breast_cancer .
8630380	0	doxorubicin	61,72	GM-CSF	236,242	doxorubicin	GM-CSF	MESH:D004317	1437	Chemical	Gene	trial|nmod|START_ENTITY trial|nmod|END_ENTITY	Prospective , randomized trial of 5-fluorouracil , leucovorin , doxorubicin , and cyclophosphamide chemotherapy in combination with the interleukin-3 / granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- fusion protein -LRB- PIXY321 -RRB- versus GM-CSF in patients with advanced_breast_cancer .
8951354	0	doxorubicin	21,32	GM-CSF	0,6	doxorubicin	GM-CSF	MESH:D004317	1437	Chemical	Gene	escalation|compound|START_ENTITY allow|dobj|escalation allow|nsubj|END_ENTITY	GM-CSF did not allow doxorubicin dose escalation in the MAID regimen : a phase I trial .
10550137	0	doxorubicin	66,77	Granulocyte-macrophage_colony-stimulating_factor	0,48	doxorubicin	Granulocyte-macrophage colony-stimulating factor	MESH:D004317	1437	Chemical	Gene	treatment|nmod|START_ENTITY treatment|amod|END_ENTITY	Granulocyte-macrophage_colony-stimulating_factor treatment before doxorubicin and cyclophosphamide chemotherapy priming in women with early-stage_breast_cancer .
12820652	0	doxorubicin	46,57	Hsp25	0,5	doxorubicin	Hsp25	MESH:D004317	3315	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|END_ENTITY	Hsp25 and Hsp70 in rodent_tumors treated with doxorubicin and lovastatin .
7919461	0	doxorubicin	57,68	IL-1	17,21	doxorubicin	IL-1	MESH:D004317	403974(Tax:9615)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of dog IL-1 by free and liposomal encapsulated doxorubicin .
11964305	0	doxorubicin	124,135	MDM2	116,120	doxorubicin	MDM2	MESH:D004317	4193	Chemical	Gene	resistance|compound|START_ENTITY END_ENTITY|nmod|resistance	MDM2 induces NF-kappaB/p65 expression transcriptionally through Sp1-binding sites : a novel , p53-independent role of MDM2 in doxorubicin resistance in acute_lymphoblastic_leukemia .
21801152	0	doxorubicin	47,58	MDR-1	131,136	doxorubicin	MDR-1	MESH:D004317	5243	Chemical	Gene	cytotoxicity|nmod|START_ENTITY synergizes|dobj|cytotoxicity synergizes|nmod|modulation modulation|nmod|END_ENTITY	Chebulagic_acid synergizes the cytotoxicity of doxorubicin in human hepatocellular_carcinoma through COX-2 dependant modulation of MDR-1 .
24901713	0	doxorubicin	73,84	MDR-1	106,111	doxorubicin	MDR-1	MESH:D004317	5243	Chemical	Gene	START_ENTITY|nmod|downregulation downregulation|nmod|expression expression|compound|END_ENTITY	Sinomenine sensitizes multidrug-resistant colon_cancer cells -LRB- Caco-2 -RRB- to doxorubicin by downregulation of MDR-1 expression .
7903690	0	doxorubicin	46,57	MDR-1	0,5	doxorubicin	MDR-1	MESH:D004317	5243	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	MDR-1 expression and response to vincristine , doxorubicin , and dexamethasone chemotherapy in multiple_myeloma refractory to alkylating agents .
24495648	0	doxorubicin	40,51	MG132	59,64	doxorubicin	MG132	MESH:D004317	875581(Tax:243273)	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|compound|END_ENTITY	Sensitization of U937 leukemia cells to doxorubicin by the MG132 proteasome inhibitor induces an increase in apoptosis by suppressing NF-kappa_B and mitochondrial membrane potential loss .
10632461	0	doxorubicin	129,140	Multidrug_resistance-1	0,22	doxorubicin	Multidrug resistance-1	MESH:D004317	5243	Chemical	Gene	correlates|nmod|START_ENTITY END_ENTITY|dep|correlates	Multidrug_resistance-1 and p-glycoprotein in human chondrosarcoma cell lines : expression correlates with decreased intracellular doxorubicin and in vitro chemoresistance .
15899819	0	doxorubicin	33,44	Nuclear_factor-kappaB	0,21	doxorubicin	Nuclear factor-kappaB	MESH:D004317	4790	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Nuclear_factor-kappaB induced by doxorubicin is deficient in phosphorylation and acetylation and represses nuclear_factor-kappaB-dependent transcription in cancer cells .
20201777	0	doxorubicin	145,156	P-Glycoprotein	0,14	doxorubicin	P-Glycoprotein	MESH:D004317	5243	Chemical	Gene	exposed|nmod|START_ENTITY cells|acl|exposed 1-phenyl-2-decanoylamino-3-morpholino-1-propanol|nmod|cells effect|nmod|1-phenyl-2-decanoylamino-3-morpholino-1-propanol target|nmod|effect target|nsubj|END_ENTITY	P-Glycoprotein is not a key target for the chemosensitizing effect of 1-phenyl-2-decanoylamino-3-morpholino-1-propanol in HepG2 cells exposed to doxorubicin .
10571255	0	doxorubicin	12,23	P-glycoprotein	65,79	doxorubicin	P-glycoprotein	MESH:D004317	5243	Chemical	Gene	cytotoxicity|compound|START_ENTITY Increase|nmod|cytotoxicity Increase|nmod|inhibition inhibition|nmod|activity activity|amod|END_ENTITY	Increase in doxorubicin cytotoxicity by carvedilol inhibition of P-glycoprotein activity .
10573204	0	doxorubicin	29,40	P-glycoprotein	98,112	doxorubicin	P-glycoprotein	MESH:D004317	5243	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY pharmacokinetics|nmod|GF120918 GF120918|appos|inhibitor inhibitor|nmod|END_ENTITY	Clinical pharmacokinetics of doxorubicin in combination with GF120918 , a potent inhibitor of MDR1 P-glycoprotein .
10663638	0	doxorubicin	93,104	P-glycoprotein	10,24	doxorubicin	P-glycoprotein	MESH:D004317	5243	Chemical	Gene	penetration|nmod|START_ENTITY modulation|nmod|penetration modulation|nsubj|Effect Effect|nmod|END_ENTITY	Effect of P-glycoprotein modulation with cyclosporin_A on cerebrospinal fluid penetration of doxorubicin in non-human primates .
10757444	0	doxorubicin	162,173	P-glycoprotein	87,101	doxorubicin	P-glycoprotein	MESH:D004317	5243	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|pretreatment pretreatment|nmod|multidrug multidrug|dobj|expression expression|amod|END_ENTITY	Effects of mitomycin_C and carboplatin pretreatment on multidrug resistance-associated P-glycoprotein expression and on subsequent suppression of tumor growth by doxorubicin and paclitaxel in human metastatic breast_cancer xenografted nude_mice .
11042226	0	doxorubicin	15,26	P-glycoprotein	61,75	doxorubicin	P-glycoprotein	MESH:D004317	5243	Chemical	Gene	START_ENTITY|nmod|rhodamine-123 rhodamine-123|acl|assessing assessing|dobj|functionality functionality|amod|END_ENTITY	Specificity of doxorubicin versus rhodamine-123 in assessing P-glycoprotein functionality in the LLC-PK1 , LLC-PK1 : MDR1 and Caco-2 cell lines .
11144235	0	doxorubicin	69,80	P-glycoprotein	101,115	doxorubicin	P-glycoprotein	MESH:D004317	5243	Chemical	Gene	START_ENTITY|nmod|cells cells|acl|displaying displaying|dobj|END_ENTITY	The effect of fatty_acids and analogues upon intracellular levels of doxorubicin in cells displaying P-glycoprotein mediated multidrug resistance .
11379779	0	doxorubicin	12,23	P-glycoprotein	54,68	doxorubicin	P-glycoprotein	MESH:D004317	5243	Chemical	Gene	cytotoxicity|compound|START_ENTITY Increase|nmod|cytotoxicity Increase|nmod|inhibition inhibition|nmod|activity activity|amod|END_ENTITY	Increase in doxorubicin cytotoxicity by inhibition of P-glycoprotein activity with lomerizine .
11640914	0	doxorubicin	61,72	P-glycoprotein	15,29	doxorubicin	P-glycoprotein	MESH:D004317	67078(Tax:10090)	Chemical	Gene	tissues|nmod|START_ENTITY expression|nmod|tissues expression|amod|END_ENTITY	Alterations in P-glycoprotein expression in mouse tissues by doxorubicin : implications for pharmacokinetics in multiple dosing regimens .
12473580	0	doxorubicin	139,150	P-glycoprotein	28,42	doxorubicin	P-glycoprotein	MESH:D004317	5243	Chemical	Gene	administered|nmod|START_ENTITY administered|nsubj|trial trial|nmod|inhibitor inhibitor|amod|END_ENTITY	A phase I trial of a potent P-glycoprotein inhibitor , Zosuquidar .3 HCl_trihydrochloride -LRB- LY335979 -RRB- , administered orally in combination with doxorubicin in patients with advanced malignancies .
1356441	0	doxorubicin	30,41	P-glycoprotein	75,89	doxorubicin	P-glycoprotein	MESH:D004317	5243	Chemical	Gene	efflux|compound|START_ENTITY pump|nsubj|efflux pump|xcomp|similar similar|nmod|END_ENTITY	In archaebacteria , there is a doxorubicin efflux pump similar to mammalian P-glycoprotein .
14622113	0	doxorubicin	95,106	P-glycoprotein	0,14	doxorubicin	P-glycoprotein	MESH:D004317	287115(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	P-glycoprotein -LRB- ABCB1 -RRB- but not multidrug_resistance-associated_protein_1 -LRB- ABCC1 -RRB- is induced by doxorubicin in primary cultures of rat astrocytes .
15161679	0	doxorubicin	141,152	P-glycoprotein	28,42	doxorubicin	P-glycoprotein	MESH:D004317	5243	Chemical	Gene	administered|nmod|START_ENTITY administered|nsubj|trial trial|nmod|inhibitor inhibitor|amod|END_ENTITY	A Phase I trial of a potent P-glycoprotein inhibitor , zosuquidar_trihydrochloride -LRB- LY335979 -RRB- , administered intravenously in combination with doxorubicin in patients with advanced malignancy .
15778272	0	doxorubicin	83,94	P-glycoprotein	39,53	doxorubicin	P-glycoprotein	MESH:D004317	67078(Tax:10090)	Chemical	Gene	Impact|nmod|START_ENTITY Impact|nmod|changes changes|nmod|expression expression|amod|END_ENTITY	Impact of endotoxin-induced changes in P-glycoprotein expression on disposition of doxorubicin in mice .
15861398	0	doxorubicin	141,152	P-glycoprotein	48,62	doxorubicin	P-glycoprotein	MESH:D004317	67078(Tax:10090)	Chemical	Gene	action|compound|START_ENTITY _|nmod|action _|nsubj|contribution contribution|nmod|END_ENTITY	Major contribution of the multidrug transporter P-glycoprotein to reduced susceptibility of poly -LRB- ADP-ribose -RRB- _ polymerase-1 knock-out cells to doxorubicin action .
15906164	0	doxorubicin	82,93	P-glycoprotein	0,14	doxorubicin	P-glycoprotein	MESH:D004317	5243	Chemical	Gene	strategies|compound|START_ENTITY response|nmod|strategies induction|nmod|response induction|amod|END_ENTITY	P-glycoprotein induction and tumor cell-kill dynamics in response to differential doxorubicin dosing strategies : a theoretical pharmacodynamic model .
15937726	0	doxorubicin	151,162	P-glycoprotein	48,62	doxorubicin	P-glycoprotein	MESH:D004317	287115(Tax:10116)	Chemical	Gene	Investigation|nmod|START_ENTITY Investigation|nmod|END_ENTITY	Investigation of the influence of modulation of P-glycoprotein by a multiple dosing regimen of tamoxifen on the pharmacokinetics and toxicodynamics of doxorubicin .
1681887	0	doxorubicin	64,75	P-glycoprotein	105,119	doxorubicin	P-glycoprotein	MESH:D004317	5243	Chemical	Gene	distribution|compound|START_ENTITY distribution|appos|independent independent|nmod|END_ENTITY	Early multidrug resistance , defined by changes in intracellular doxorubicin distribution , independent of P-glycoprotein .
16962737	0	doxorubicin	55,66	P-glycoprotein	163,177	doxorubicin	P-glycoprotein	MESH:D004317	67078(Tax:10090)	Chemical	Gene	pressure|nmod|START_ENTITY cultivated|nmod|pressure cells|acl|cultivated express|nsubj|cells express|dobj|mechanisms mechanisms|acl|multidrug multidrug|advcl|overexpression overexpression|nmod|END_ENTITY	L1210 cells cultivated under the selection pressure of doxorubicin or vincristine express common mechanisms of multidrug resistance based on the overexpression of P-glycoprotein .
17526808	0	doxorubicin	54,65	P-glycoprotein	94,108	doxorubicin	P-glycoprotein	MESH:D004317	5243	Chemical	Gene	effect|nmod|START_ENTITY inhibits|dobj|effect inhibits|parataxis|kinase kinase|nsubj|role role|nmod|protein protein|amod|END_ENTITY	High-dose acetaminophen inhibits the lethal effect of doxorubicin in HepG2 cells : the role of P-glycoprotein and mitogen-activated protein kinase p44/42 pathway .
18650266	0	doxorubicin	17,28	P-glycoprotein	55,69	doxorubicin	P-glycoprotein	MESH:D004317	5243	Chemical	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Chemotoxicity of doxorubicin and surface expression of P-glycoprotein -LRB- MDR1 -RRB- is regulated by the Pseudomonas_aeruginosa toxin Cif .
19264847	0	doxorubicin	15,26	P-glycoprotein	210,224	doxorubicin	P-glycoprotein	MESH:D004317	5243	Chemical	Gene	cytotoxicity|compound|START_ENTITY Enhancement|nmod|cytotoxicity -3|nsubj|Enhancement -3|parataxis|benzenesulfonamide benzenesulfonamide|acl|inhibiting inhibiting|dobj|activity activity|amod|END_ENTITY	Enhancement of doxorubicin cytotoxicity on human esophageal_squamous_cell_carcinoma cells by indomethacin and 4 - -LSB- 5 - -LRB- 4-chlorophenyl -RRB- -3 - -LRB- trifluoromethyl -RRB- -1 H-pyrazol-1-yl -RSB- benzenesulfonamide -LRB- SC236 -RRB- via inhibiting P-glycoprotein activity .
1974823	0	doxorubicin	128,139	P-glycoprotein	72,86	doxorubicin	P-glycoprotein	MESH:D004317	5243	Chemical	Gene	resistance|compound|START_ENTITY selection|nmod|resistance precedes|nmod|selection precedes|dobj|expression expression|amod|END_ENTITY	Non-P-glycoprotein mediated mechanism for multidrug resistance precedes P-glycoprotein expression during in vitro selection for doxorubicin resistance in a human lung_cancer cell line .
1979457	0	doxorubicin	43,54	P-glycoprotein	98,112	doxorubicin	P-glycoprotein	MESH:D004317	5243	Chemical	Gene	resistance|nmod|START_ENTITY Correlations|nmod|resistance Correlations|nmod|END_ENTITY	Correlations between natural resistance to doxorubicin , proliferative activity , and expression of P-glycoprotein 170 in human kidney_tumor cell lines .
19807929	0	doxorubicin	85,96	P-glycoprotein	17,31	doxorubicin	P-glycoprotein	MESH:D004317	67078(Tax:10090)	Chemical	Gene	distribution|nmod|START_ENTITY influence|nmod|distribution influence|nmod|expression expression|amod|END_ENTITY	The influence of P-glycoprotein expression and its inhibitors on the distribution of doxorubicin in breast_tumors .
19827298	0	doxorubicin	64,75	P-glycoprotein	102,116	doxorubicin	P-glycoprotein	MESH:D004317	287115(Tax:10116)	Chemical	Gene	bioavailability|nmod|START_ENTITY Effects|nmod|bioavailability Effects|dep|role role|nmod|inhibition inhibition|amod|END_ENTITY	Effects of baicalein , an antioxidant , on the bioavailability of doxorubicin in rats : possible role of P-glycoprotein inhibition by baicalein .
20088680	0	doxorubicin	13,24	P-glycoprotein	39,53	doxorubicin	P-glycoprotein	MESH:D004317	5243	Chemical	Gene	resistance|compound|START_ENTITY Reduction|nmod|resistance Reduction|nmod|cells cells|amod|END_ENTITY	Reduction of doxorubicin resistance in P-glycoprotein overexpressing cells by hybrid cell-penetrating and drug-binding peptide .
21281816	0	doxorubicin	58,69	P-glycoprotein	24,38	doxorubicin	P-glycoprotein	MESH:D004317	5243	Chemical	Gene	chemoresistance|compound|START_ENTITY associated|nmod|chemoresistance associated|nsubjpass|expression expression|nmod|END_ENTITY	Increased expression of P-glycoprotein is associated with doxorubicin chemoresistance in the metastatic 4T1 breast_cancer model .
21377266	0	doxorubicin	51,62	P-glycoprotein	118,132	doxorubicin	P-glycoprotein	MESH:D004317	5243	Chemical	Gene	cytotoxicity|nmod|START_ENTITY enhance|dobj|cytotoxicity enhance|nmod|cells cells|acl|inhibiting inhibiting|dobj|expression expression|amod|END_ENTITY	Indomethacin and SC236 enhance the cytotoxicity of doxorubicin in human hepatocellular_carcinoma cells via inhibiting P-glycoprotein and MRP1 expression .
21491921	0	doxorubicin	22,33	P-glycoprotein	73,87	doxorubicin	P-glycoprotein	MESH:D004317	5243	Chemical	Gene	reverses|nsubj|START_ENTITY reverses|advcl|inhibiting inhibiting|dobj|END_ENTITY	Liposome-encapsulated doxorubicin reverses drug resistance by inhibiting P-glycoprotein in human cancer cells .
21590773	0	doxorubicin	18,29	P-glycoprotein	59,73	doxorubicin	P-glycoprotein	MESH:D004317	67078(Tax:10090)	Chemical	Gene	results|compound|START_ENTITY results|nmod|expression expression|amod|END_ENTITY	Acute exposure to doxorubicin results in increased cardiac P-glycoprotein expression .
21737631	0	doxorubicin	89,100	P-glycoprotein	0,14	doxorubicin	P-glycoprotein	MESH:D004317	287115(Tax:10116)	Chemical	Gene	uptake|nmod|START_ENTITY increase|dobj|uptake increase|nsubj|modulation modulation|amod|END_ENTITY	P-glycoprotein modulation by valspodar and cyclosporin does not increase tumor uptake of doxorubicin administered via isolated lung perfusion to rats bearing sarcoma lung metastases .
22191778	0	doxorubicin	77,88	P-glycoprotein	0,14	doxorubicin	P-glycoprotein	MESH:D004317	5243	Chemical	Gene	resistance|compound|START_ENTITY overcomes|dobj|resistance overcomes|nsubj|silencing silencing|amod|END_ENTITY	P-glycoprotein silencing with siRNA delivered by DOPE-modified PEI overcomes doxorubicin resistance in breast_cancer cells .
22217342	0	doxorubicin	25,36	P-glycoprotein	74,88	doxorubicin	P-glycoprotein	MESH:D004317	5243	Chemical	Gene	resistance|compound|START_ENTITY induces|dobj|resistance induces|nmod|spheroids spheroids|nmod|expression expression|amod|END_ENTITY	HIF-1 activation induces doxorubicin resistance in MCF7 3-D spheroids via P-glycoprotein expression : a potential model of the chemo-resistance of invasive micropapillary_carcinoma_of_the_breast .
22361031	0	doxorubicin	116,127	P-glycoprotein	17,31	doxorubicin	P-glycoprotein	MESH:D004317	287115(Tax:10116)	Chemical	Gene	reduce|nmod|START_ENTITY reduce|nsubj|Encapsulation Encapsulation|nmod|inhibitors inhibitors|amod|END_ENTITY	Encapsulation of P-glycoprotein inhibitors by polymeric micelles can reduce their pharmacokinetic interactions with doxorubicin .
23602050	0	doxorubicin	89,100	P-glycoprotein	24,38	doxorubicin	P-glycoprotein	MESH:D004317	5243	Chemical	Gene	nucleus|nmod|START_ENTITY protection|nmod|nucleus responsible|nmod|protection responsible|nsubj|localization localization|nmod|END_ENTITY	Nuclear localization of P-glycoprotein is responsible for protection of the nucleus from doxorubicin in the resistant LoVo cell line .
24370495	0	doxorubicin	74,85	P-glycoprotein	48,62	doxorubicin	P-glycoprotein	MESH:D004317	5243	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Ursodeoxycholic_acid inhibits overexpression of P-glycoprotein induced by doxorubicin in HepG2 cells .
24396453	0	doxorubicin	21,32	P-glycoprotein	88,102	doxorubicin	P-glycoprotein	MESH:D004317	5243	Chemical	Gene	activity|nmod|START_ENTITY resistant|nsubj|activity resistant|nmod|encapsulation encapsulation|nmod|inhibitor inhibitor|amod|END_ENTITY	Enhanced activity of doxorubicin in drug resistant A549 tumor cells by encapsulation of P-glycoprotein inhibitor in PLGA-based nanovectors .
24830744	0	doxorubicin	27,38	P-glycoprotein	113,127	doxorubicin	P-glycoprotein	MESH:D004317	5243	Chemical	Gene	synergizes|nmod|START_ENTITY synergizes|advcl|inhibiting inhibiting|dobj|END_ENTITY	Evodiamine synergizes with doxorubicin in the treatment of chemoresistant human breast_cancer without inhibiting P-glycoprotein .
24868599	0	doxorubicin	58,69	P-glycoprotein	106,120	doxorubicin	P-glycoprotein	MESH:D004317	5243	Chemical	Gene	START_ENTITY|nmod|modulation modulation|nmod|END_ENTITY	FTY720 enhances chemosensitivity of colon_cancer cells to doxorubicin and etoposide via the modulation of P-glycoprotein and multidrug_resistance_protein_1 .
25092974	0	doxorubicin	60,71	P-glycoprotein	135,149	doxorubicin	P-glycoprotein	MESH:D004317	5243	Chemical	Gene	inhibitor|nmod|START_ENTITY co-delivery|nmod|inhibitor stabilized|nsubj|co-delivery stabilized|nmod|expression expression|amod|END_ENTITY	The co-delivery of a low-dose P-glycoprotein inhibitor with doxorubicin sterically stabilized liposomes against breast_cancer with low P-glycoprotein expression .
25092974	0	doxorubicin	60,71	P-glycoprotein	30,44	doxorubicin	P-glycoprotein	MESH:D004317	5243	Chemical	Gene	inhibitor|nmod|START_ENTITY inhibitor|amod|END_ENTITY	The co-delivery of a low-dose P-glycoprotein inhibitor with doxorubicin sterically stabilized liposomes against breast_cancer with low P-glycoprotein expression .
25410120	0	doxorubicin	186,197	P-glycoprotein	97,111	doxorubicin	P-glycoprotein	MESH:D004317	5243	Chemical	Gene	cells|nmod|START_ENTITY Relationship|nmod|cells Relationship|nmod|END_ENTITY	Relationship between therapeutic efficacy of doxorubicin-transferrin conjugate and expression of P-glycoprotein in chronic erythromyeloblastoid_leukemia cells sensitive and resistant to doxorubicin .
2565403	0	doxorubicin	14,25	P-glycoprotein	89,103	doxorubicin	P-glycoprotein	MESH:D004317	5243	Chemical	Gene	resistance|compound|START_ENTITY Prediction|nmod|resistance Prediction|acl|vitro vitro|nmod|myeloma myeloma|nmod|staining staining|amod|END_ENTITY	Prediction of doxorubicin resistance in vitro in myeloma , lymphoma , and breast_cancer by P-glycoprotein staining .
25681670	0	doxorubicin	26,37	P-glycoprotein	111,125	doxorubicin	P-glycoprotein	MESH:D004317	5243	Chemical	Gene	doses|nmod|START_ENTITY effective|nsubj|doses effective|nmod|dose dose|nmod|tumors tumors|acl|overexpressing overexpressing|dobj|END_ENTITY	Two repeated low doses of doxorubicin are more effective than a single high dose against tumors overexpressing P-glycoprotein .
25824409	0	doxorubicin	58,69	P-glycoprotein	89,103	doxorubicin	P-glycoprotein	MESH:D004317	5243	Chemical	Gene	START_ENTITY|advcl|inhibiting inhibiting|dobj|expression expression|amod|END_ENTITY	Gambogic_acid sensitizes resistant breast_cancer cells to doxorubicin through inhibiting P-glycoprotein and suppressing survivin expression .
26486517	0	doxorubicin	114,125	P-glycoprotein	68,82	doxorubicin	P-glycoprotein	MESH:D004317	5243	Chemical	Gene	combination|nmod|START_ENTITY study|nmod|combination study|nmod|tariquidar tariquidar|appos|inhibitor inhibitor|amod|END_ENTITY	Pharmacokinetic and pharmacodynamic study of tariquidar -LRB- XR9576 -RRB- , a P-glycoprotein inhibitor , in combination with doxorubicin , vinorelbine , or docetaxel in children and adolescents with refractory solid tumors .
26530267	0	doxorubicin	22,33	P-glycoprotein	59,73	doxorubicin	P-glycoprotein	MESH:D004317	287115(Tax:10116)	Chemical	Gene	resistance|compound|START_ENTITY reverses|dobj|resistance reverses|advcl|inhibiting inhibiting|dobj|END_ENTITY	Temozolomide reverses doxorubicin resistance by inhibiting P-glycoprotein in malignant_glioma cells .
26733176	0	doxorubicin	170,181	P-glycoprotein	10,24	doxorubicin	P-glycoprotein	MESH:D004317	5243	Chemical	Gene	resistance|nmod|START_ENTITY Targeting|nsubj|resistance Targeting|dobj|expression expression|amod|END_ENTITY	Targeting P-glycoprotein expression and cancer cell energy metabolism : combination of metformin and 2-deoxyglucose reverses the multidrug resistance of K562/Dox cells to doxorubicin .
7982498	0	doxorubicin	44,55	P-glycoprotein	120,134	doxorubicin	P-glycoprotein	MESH:D004317	5243	Chemical	Gene	cytotoxicity|compound|START_ENTITY potentiates|dobj|cytotoxicity potentiates|advcl|multidrug multidrug|nmod|inhibition inhibition|nmod|function function|amod|END_ENTITY	The antiprogestatin drug RU_486 potentiates doxorubicin cytotoxicity in multidrug resistant cells through inhibition of P-glycoprotein function .
8603675	0	doxorubicin	109,120	P-glycoprotein	30,44	doxorubicin	P-glycoprotein	MESH:D004317	5243	Chemical	Gene	distribution|compound|START_ENTITY mechanisms|nmod|distribution showing|dobj|mechanisms immunolocalization|acl|showing immunolocalization|nmod|END_ENTITY	Nuclear immunolocalization of P-glycoprotein in multidrug-resistant cell lines showing similar mechanisms of doxorubicin distribution .
9525837	0	doxorubicin	14,25	P-glycoprotein	108,122	doxorubicin	P-glycoprotein	MESH:D004317	287115(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY Modulation|nmod|concentration Modulation|acl|expressing expressing|dobj|END_ENTITY	Modulation of doxorubicin concentration by cyclosporin_A in brain and testicular barrier tissues expressing P-glycoprotein in rats .
9914792	0	doxorubicin	77,88	P-glycoprotein	115,129	doxorubicin	P-glycoprotein	MESH:D004317	5243	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Inhibitory effects of a cyclosporin derivative , SDZ_PSC_833 , on transport of doxorubicin and vinblastine via human P-glycoprotein .
25482933	0	doxorubicin	76,87	P-gp	106,110	doxorubicin	P-gp	MESH:D004317	5243	Chemical	Gene	START_ENTITY|advcl|downregulating downregulating|dobj|expression expression|compound|END_ENTITY	Dasatinib reverses the multidrug resistance of breast_cancer MCF-7 cells to doxorubicin by downregulating P-gp expression via inhibiting the activation of ERK signaling pathway .
8673929	0	doxorubicin	65,76	P53	9,12	doxorubicin	P53	MESH:D004317	7157	Chemical	Gene	resistance|nmod|START_ENTITY associated|nmod|resistance associated|nsubjpass|mutations mutations|compound|END_ENTITY	Specific P53 mutations are associated with de novo resistance to doxorubicin in breast_cancer patients .
25466181	0	doxorubicin	64,75	PPM1D	35,40	doxorubicin	PPM1D	MESH:D004317	8493	Chemical	Gene	effect|nmod|START_ENTITY enhances|dobj|effect enhances|nsubj|END_ENTITY	Inhibition of C-terminal truncated PPM1D enhances the effect of doxorubicin on cell viability in human colorectal_carcinoma cell line .
12527936	0	doxorubicin	30,41	RLIP76	8,14	doxorubicin	RLIP76	MESH:D004317	10928	Chemical	Gene	resistance|compound|START_ENTITY END_ENTITY|nmod|resistance	Role of RLIP76 in lung_cancer doxorubicin resistance : I .
12632060	0	doxorubicin	30,41	RLIP76	8,14	doxorubicin	RLIP76	MESH:D004317	10928	Chemical	Gene	resistance|compound|START_ENTITY END_ENTITY|nmod|resistance	Role of RLIP76 in lung_cancer doxorubicin resistance : II .
25106424	0	doxorubicin	19,30	RyR2	68,72	doxorubicin	RyR2	MESH:D004317	6262	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Adverse effects of doxorubicin and its metabolic product on cardiac RyR2 and SERCA2A .
26181197	0	doxorubicin	93,104	Sall2	0,5	doxorubicin	Sall2	MESH:D004317	50524(Tax:10090)	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Sall2 is required for proapoptotic Noxa expression and genotoxic_stress-induced apoptosis by doxorubicin .
10070062	0	doxorubicin	99,110	TAFII250	0,8	doxorubicin	TAFII250	MESH:D004317	270627(Tax:10090)	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|END_ENTITY	TAFII250 , Egr-1 , and D-type cyclin expression in mice and neonatal rat cardiomyocytes treated with doxorubicin .
24489651	0	doxorubicin	29,40	TFPI1	0,5	doxorubicin	TFPI1	MESH:D004317	7035	Chemical	Gene	mediates|advcl|START_ENTITY mediates|nsubj|END_ENTITY	TFPI1 mediates resistance to doxorubicin in breast_cancer cells by inducing a hypoxic-like response .
26686989	0	doxorubicin	27,38	TGF-b	4,9	doxorubicin	TGF-b	MESH:D004317	7040	Chemical	Gene	effects|compound|START_ENTITY mediates|dobj|effects mediates|nsubj|END_ENTITY	The TGF-b pathway mediates doxorubicin effects on cardiac endothelial cells .
23922104	0	doxorubicin	85,96	TP53	100,104	doxorubicin	TP53	MESH:D004317	7157	Chemical	Gene	START_ENTITY|nmod|cells cells|nummod|END_ENTITY	Src kinases in chondrosarcoma chemoresistance and migration : dasatinib sensitises to doxorubicin in TP53 mutant cells .
11857034	0	doxorubicin	118,129	TRAIL	168,173	doxorubicin	TRAIL	MESH:D004317	8743	Chemical	Gene	delivery|compound|START_ENTITY delivery|nmod|END_ENTITY	Resistance of prostate_cancer cells to soluble TNF-related apoptosis-inducing ligand -LRB- TRAIL/Apo2L -RRB- can be overcome by doxorubicin or adenoviral delivery of full-length TRAIL .
9523988	0	doxorubicin	26,37	Transferrin	0,11	doxorubicin	Transferrin	MESH:D004317	7018	Chemical	Gene	conjugates|nmod|START_ENTITY conjugates|compound|END_ENTITY	Transferrin conjugates of doxorubicin : synthesis , characterization , cellular uptake , and in vitro efficacy .
17418594	0	doxorubicin	63,74	Transforming_growth_factor_beta-1	0,33	doxorubicin	Transforming growth factor beta-1	MESH:D004317	7040	Chemical	Gene	effect|nmod|START_ENTITY enhances|dobj|effect enhances|nsubj|END_ENTITY	Transforming_growth_factor_beta-1 enhances cytotoxic effect of doxorubicin in human lung_adenocarcinoma cells of A549 line .
23209748	0	doxorubicin	43,54	TrkB	79,83	doxorubicin	TrkB	MESH:D004317	4915	Chemical	Gene	START_ENTITY|advcl|decreasing decreasing|dobj|END_ENTITY	miR-200c sensitizes breast_cancer cells to doxorubicin treatment by decreasing TrkB and Bmi1 expression .
18972897	0	doxorubicin	14,25	VEGF	86,90	doxorubicin	VEGF	MESH:D004317	7422	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of doxorubicin on the changes of serum vascular_endothelial_growth_factor -LRB- VEGF -RRB- in patients with hepatocellular_carcinoma after transcatheter arterial chemoembolization -LRB- TACE -RRB- .
25275022	0	doxorubicin	95,106	VEGF	27,31	doxorubicin	VEGF	MESH:D004317	7422	Chemical	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Differential expression of VEGF and IL-1alpha after photodynamic treatment in combination with doxorubicin or taxotere .
20559024	0	doxorubicin	20,31	ZAK	0,3	doxorubicin	ZAK	MESH:D004317	51776	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	ZAK is required for doxorubicin , a novel ribotoxic stressor , to induce SAPK activation and apoptosis in HaCaT cells .
22263831	0	doxorubicin	11,22	apolipoprotein-B	51,67	doxorubicin	apolipoprotein-B	MESH:D004317	54225(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of doxorubicin on myocardial expression of apolipoprotein-B .
11715857	0	doxorubicin	24,35	atrial_natriuretic_peptide	39,65	doxorubicin	atrial natriuretic peptide	MESH:D004317	24602(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|amod|END_ENTITY	Differential effects of doxorubicin on atrial_natriuretic_peptide expression in vivo and in vitro .
1296877	0	doxorubicin	76,87	catalase	40,48	doxorubicin	catalase	MESH:D004317	24248(Tax:10116)	Chemical	Gene	-RSB-|compound|START_ENTITY toxicity|nmod|-RSB- END_ENTITY|nmod|toxicity	-LSB- The effect of superoxide dismutase and catalase on the delayed toxicity of doxorubicin -RSB- .
3428124	0	doxorubicin	11,22	catalase	38,46	doxorubicin	catalase	MESH:D004317	12359(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of doxorubicin on mouse heart catalase .
8647872	0	doxorubicin	15,26	catalase	63,71	doxorubicin	catalase	MESH:D004317	12359(Tax:10090)	Chemical	Gene	Suppression|nmod|START_ENTITY cardiotoxicity|nsubj|Suppression cardiotoxicity|nmod|overexpression overexpression|nmod|END_ENTITY	Suppression of doxorubicin cardiotoxicity by overexpression of catalase in the heart of transgenic_mice .
16284694	0	doxorubicin	14,25	cyclin_A	47,55	doxorubicin	cyclin A	MESH:D004317	890	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|nmod|END_ENTITY	The effect of doxorubicin on the expression of cyclin_A in K-562 leukemia cell line .
22950819	0	doxorubicin	106,117	cyclin_A	14,22	doxorubicin	cyclin A	MESH:D004317	890	Chemical	Gene	exposed|nmod|START_ENTITY exposed|nsubj|Expression Expression|nmod|END_ENTITY	Expression of cyclin_A , B1_and_D1 after induction of cell cycle arrest in the Jurkat cell line exposed to doxorubicin .
24764322	0	doxorubicin	45,56	cyclin_D1	14,23	doxorubicin	cyclin D1	MESH:D004317	595	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of cyclin_D1 after treatment with doxorubicin in the HL-60 cell line .
7665224	0	doxorubicin	36,47	endothelin-1	7,19	doxorubicin	endothelin-1	MESH:D004317	1906	Chemical	Gene	marker|nmod|START_ENTITY END_ENTITY|nmod|marker	Plasma endothelin-1 as a marker for doxorubicin cardiotoxicity .
25308735	0	doxorubicin	132,143	exportin_6	12,22	doxorubicin	exportin 6	MESH:D004317	23214	Chemical	Gene	treatment|compound|START_ENTITY role|nmod|treatment role|nmod|END_ENTITY	The role of exportin_6 in cytoskeletal-mediated cell death and cell adhesion in human non-small-cell_lung_carcinoma cells following doxorubicin treatment .
11351295	0	doxorubicin	111,122	glutathione_S-transferase_P1	8,36	doxorubicin	glutathione S-transferase P1	MESH:D004317	2950	Chemical	Gene	resistance|compound|START_ENTITY END_ENTITY|nmod|resistance	Role of glutathione_S-transferase_P1 , P-glycoprotein and multidrug_resistance-associated_protein_1 in acquired doxorubicin resistance .
10438370	0	doxorubicin	78,89	interferon-gamma	22,38	doxorubicin	interferon-gamma	MESH:D004317	15978(Tax:10090)	Chemical	Gene	liposome-incorporated|dobj|START_ENTITY liposome-incorporated|nsubj|effect effect|nmod|END_ENTITY	Synergistic effect of interferon-gamma and mannosylated liposome-incorporated doxorubicin in the therapy of experimental visceral_leishmaniasis .
1457750	0	doxorubicin	21,32	interferon-gamma	64,80	doxorubicin	interferon-gamma	MESH:D004317	25712(Tax:10116)	Chemical	Gene	efficacy|nmod|START_ENTITY efficacy|nmod|END_ENTITY	Improved efficacy of doxorubicin by simultaneous treatment with interferon-gamma and interleukin-2 .
1832272	0	doxorubicin	37,48	interferon-gamma	81,97	doxorubicin	interferon-gamma	MESH:D004317	3458	Chemical	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	In vitro studies on the influence of doxorubicin in combination with recombinant interferon-gamma on human monocytes .
8399073	0	doxorubicin	36,47	interleukin-2	17,30	doxorubicin	interleukin-2	MESH:D004317	3558	Chemical	Gene	trial|nmod|START_ENTITY trial|nmod|END_ENTITY	Phase I trial of interleukin-2 plus doxorubicin .
10100723	0	doxorubicin	74,85	interleukin_2	113,126	doxorubicin	interleukin 2	MESH:D004317	16183(Tax:10090)	Chemical	Gene	Enhancement|nmod|START_ENTITY Enhancement|nmod|END_ENTITY	Enhancement of antitumor activity of polyethylene_glycol-coated liposomal doxorubicin with soluble and liposomal interleukin_2 .
24789077	0	doxorubicin	81,92	lactate_dehydrogenase-A	119,142	doxorubicin	lactate dehydrogenase-A	MESH:D004317	3939	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Targeting glucose metabolism in chondrosarcoma cells enhances the sensitivity to doxorubicin through the inhibition of lactate_dehydrogenase-A .
8692981	0	doxorubicin	70,81	luteinizing_hormone-releasing_hormone	21,58	doxorubicin	luteinizing hormone-releasing hormone	MESH:D004317	25194(Tax:10116)	Chemical	Gene	analogs|amod|START_ENTITY analogs|nmod|END_ENTITY	Cytotoxic analogs of luteinizing_hormone-releasing_hormone containing doxorubicin or 2-pyrrolinodoxorubicin , a derivative 500-1000 times more potent .
18486258	0	doxorubicin	39,50	mTOR	14,18	doxorubicin	mTOR	MESH:D004317	21977(Tax:10090)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of mTOR in combination with doxorubicin in an experimental model of hepatocellular_carcinoma .
20501828	0	doxorubicin	54,65	mTOR	22,26	doxorubicin	mTOR	MESH:D004317	21977(Tax:10090)	Chemical	Gene	sensitivity|compound|START_ENTITY influence|dobj|sensitivity regulates|advcl|influence regulates|dobj|END_ENTITY	MiR-199a-3p regulates mTOR and c-Met to influence the doxorubicin sensitivity of human hepatocarcinoma cells .
21781495	0	doxorubicin	68,79	mdr1	88,92	doxorubicin	mdr1	MESH:D004317	5243	Chemical	Gene	START_ENTITY|acl|induced induced|dobj|expression expression|amod|END_ENTITY	-LSB- Effect of regulation of Y-box protein 1 by RNA interference on the doxorubicin induced mdr1 gene expression in K562 cells -RSB- .
24519092	0	doxorubicin	40,51	miR-30c	15,22	doxorubicin	miR-30c	MESH:D004317	407031	Chemical	Gene	Involvement|acl|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of miR-30c in resistance to doxorubicin by regulating YWHAZ in breast_cancer cells .
23546450	0	doxorubicin	63,74	miRNA-200c	0,10	doxorubicin	miRNA-200c	MESH:D004317	406985	Chemical	Gene	increases|xcomp|START_ENTITY increases|nsubj|END_ENTITY	miRNA-200c increases the sensitivity of breast_cancer cells to doxorubicin through the suppression of E-cadherin-mediated PTEN/Akt signaling .
24065548	0	doxorubicin	87,98	mitochondrial_ferritin	21,43	doxorubicin	mitochondrial ferritin	MESH:D004317	94033	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|effect effect|nmod|END_ENTITY	Protective effect of mitochondrial_ferritin on cytosolic iron dysregulation induced by doxorubicin in HeLa cells .
11745235	0	doxorubicin	54,65	multidrug_resistance-1	85,107	doxorubicin	multidrug resistance-1	MESH:D004317	5243	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Wild type p53 sensitizes soft tissue sarcoma cells to doxorubicin by down-regulating multidrug_resistance-1 expression .
15473893	0	doxorubicin	77,88	multidrug_resistance-associated_protein_1	26,67	doxorubicin	multidrug resistance-associated protein 1	MESH:D004317	4363	Chemical	Gene	resistance|compound|START_ENTITY resistance|amod|END_ENTITY	N-acetylcysteine enhances multidrug_resistance-associated_protein_1 mediated doxorubicin resistance .
26600514	0	doxorubicin	50,61	multidrug_resistance-associated_protein_1	84,125	doxorubicin	multidrug resistance-associated protein 1	MESH:D004317	4363	Chemical	Gene	START_ENTITY|nmod|downregulation downregulation|nmod|END_ENTITY	Meloxicam increases intracellular accumulation of doxorubicin via downregulation of multidrug_resistance-associated_protein_1 -LRB- MRP1 -RRB- in A549 cells .
17369602	0	doxorubicin	116,127	p-53	0,4	doxorubicin	p-53	MESH:D004317	7157	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|mutations mutations|amod|END_ENTITY	p-53 gene mutations as a predictive marker in a population of advanced breast_cancer patients randomly treated with doxorubicin or docetaxel in the context of a phase III clinical trial .
19739078	0	doxorubicin	52,63	p-glycoprotein	17,31	doxorubicin	p-glycoprotein	MESH:D004317	5243	Chemical	Gene	cytotoxicity|compound|START_ENTITY enhances|dobj|cytotoxicity enhances|nsubj|impact impact|nmod|END_ENTITY	Double impact on p-glycoprotein by statins enhances doxorubicin cytotoxicity in human neuroblastoma cells .
11745235	0	doxorubicin	54,65	p53	10,13	doxorubicin	p53	MESH:D004317	7157	Chemical	Gene	sensitizes|xcomp|START_ENTITY sensitizes|nsubj|END_ENTITY	Wild type p53 sensitizes soft tissue sarcoma cells to doxorubicin by down-regulating multidrug_resistance-1 expression .
11899648	0	doxorubicin	78,89	p53	24,27	doxorubicin	p53	MESH:D004317	7157	Chemical	Gene	response|nmod|START_ENTITY prediction|nmod|response END_ENTITY|nmod|prediction	A study of the value of p53 , HER2 , and Bcl-2 in the prediction of response to doxorubicin and paclitaxel as single agents in metastatic breast_cancer : a companion study to EORTC 10923 .
12509267	0	doxorubicin	36,47	p53	14,17	doxorubicin	p53	MESH:D004317	7157	Chemical	Gene	cells|nmod|START_ENTITY cells|compound|END_ENTITY	Resistance of p53 knockout cells to doxorubicin is related to reduced formation of DNA strand breaks rather than impaired apoptotic signaling .
15026814	0	doxorubicin	68,79	p53	11,14	doxorubicin	p53	MESH:D004317	7157	Chemical	Gene	mediated|nmod|START_ENTITY lines|acl|mediated apoptosis|nmod|lines enhances|dobj|apoptosis enhances|nsubj|END_ENTITY	A modified p53 enhances apoptosis in sarcoma cell lines mediated by doxorubicin .
16432175	0	doxorubicin	128,139	p53	43,46	doxorubicin	p53	MESH:D004317	7157	Chemical	Gene	tumors|acl|START_ENTITY proliferation|nmod|tumors proliferation|compound|END_ENTITY	Benzodiazepinedione inhibitors of the Hdm2 : p53 complex suppress human tumor cell proliferation in vitro and sensitize tumors to doxorubicin in vivo .
16843502	0	doxorubicin	39,50	p53	89,92	doxorubicin	p53	MESH:D004317	22060(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|fibroblasts fibroblasts|acl|characterized characterized|nmod|mutations mutations|compound|END_ENTITY	Sulforaphane increases the efficacy of doxorubicin in mouse fibroblasts characterized by p53 mutations .
17508921	0	doxorubicin	82,93	p53	26,29	doxorubicin	p53	MESH:D004317	22060(Tax:10090)	Chemical	Gene	modulation|nmod|START_ENTITY localization|dep|modulation localization|compound|END_ENTITY	Mitochondrial and nuclear p53 localization in cardiomyocytes : redox modulation by doxorubicin -LRB- Adriamycin -RRB- ?
19304334	0	doxorubicin	45,56	p53	87,90	doxorubicin	p53	MESH:D004317	7157	Chemical	Gene	death|nmod:poss|START_ENTITY death|dep|promoting promoting|nmod|mechanism mechanism|compound|END_ENTITY	Selective ablation of Notch3 in HCC enhances doxorubicin 's death promoting effect by a p53 dependent mechanism .
20174822	0	doxorubicin	25,36	p53	105,108	doxorubicin	p53	MESH:D004317	7157	Chemical	Gene	cooperates|nmod|START_ENTITY cooperates|xcomp|induce induce|nmod|pathways pathways|compound|END_ENTITY	Nutlin-3 cooperates with doxorubicin to induce apoptosis of human hepatocellular_carcinoma cells through p53 or p73 signaling pathways .
20422012	5	doxorubicin	1238,1249	p53	1045,1048	doxorubicin	p53	MESH:D004317	7157	Chemical	Gene	inducible|nmod|START_ENTITY inducible|nmod|case case|nmod|promoters promoters|compound|END_ENTITY	Surprisingly , unlike the case for other p53 target promoters , p53-mediated transactivation of FLT1-T constructs or expression of the endogenous FLT1 gene , as well as binding of p53 and ER at the promoter constructs , was inducible by doxorubicin but not by 5-fluorouracil .
21156795	4	doxorubicin	486,497	p53	465,468	doxorubicin	p53	MESH:D004317	7157	Chemical	Gene	treatment|compound|START_ENTITY showed|nmod|treatment showed|nmod|binding binding|compound|END_ENTITY	Several cells , having p53 basal expression , showed increase in p53 DNA binding upon doxorubicin treatment .
21683812	6	doxorubicin	1103,1114	p53	1121,1124	doxorubicin	p53	MESH:D004317	7157	Chemical	Gene	induction|nmod|START_ENTITY repress|nmod|induction repress|nmod|siRNA siRNA|compound|END_ENTITY	In addition , p53 was found to repress Crm1 promoter activity , after induction with doxorubicin , with p53 siRNA blocking the effect .
21829519	0	doxorubicin	66,77	p53	35,38	doxorubicin	p53	MESH:D004317	22060(Tax:10090)	Chemical	Gene	induced|nsubj|START_ENTITY block|ccomp|induced sufficient|xcomp|block sufficient|nsubj|ablation ablation|nmod|END_ENTITY	Cardiomyocyte specific ablation of p53 is not sufficient to block doxorubicin induced cardiac fibrosis and associated cytoskeletal changes .
22267730	0	doxorubicin	56,67	p53	171,174	doxorubicin	p53	MESH:D004317	22060(Tax:10090)	Chemical	Gene	stress|compound|START_ENTITY stress|nmod|fibroblasts fibroblasts|dep|role role|nmod|END_ENTITY	Inhibition of AMP-activated protein kinase a -LRB- AMPKa -RRB- by doxorubicin accentuates genotoxic stress and cell death in mouse embryonic fibroblasts and cardiomyocytes : role of p53 and SIRT1 .
24344116	0	doxorubicin	34,45	p53	14,17	doxorubicin	p53	MESH:D004317	7157	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|Deficiency Deficiency|nmod|END_ENTITY	Deficiency in p53 is required for doxorubicin induced transcriptional activation of NF - B target genes in human breast_cancer .
24738879	0	doxorubicin	86,97	p53	101,104	doxorubicin	p53	MESH:D004317	7157	Chemical	Gene	START_ENTITY|nmod|cells cells|nummod|END_ENTITY	Inhibition enhancer_of_zeste_homologue_2 promotes senescence and apoptosis induced by doxorubicin in p53 mutant gastric_cancer cells .
25605022	0	doxorubicin	52,63	p53	0,3	doxorubicin	p53	MESH:D004317	7157	Chemical	Gene	damage|nmod|START_ENTITY checkpoint|nmod|damage activates|dobj|checkpoint activates|nsubj|END_ENTITY	p53 activates G1 checkpoint following DNA damage by doxorubicin during transient mitotic_arrest .
25749422	0	doxorubicin	17,28	p53	99,102	doxorubicin	p53	MESH:D004317	7157	Chemical	Gene	sensitivity|compound|START_ENTITY increases|dobj|sensitivity increases|nmod|degradation degradation|compound|END_ENTITY	WP1130 increases doxorubicin sensitivity in hepatocellular_carcinoma cells through usp9x-dependent p53 degradation .
25934448	0	doxorubicin	15,26	p53	49,52	doxorubicin	p53	MESH:D004317	7157	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Co-delivery of doxorubicin and tumor-suppressing p53 gene using a POSS-based star-shaped polymer for cancer therapy .
26149967	0	doxorubicin	32,43	p53	106,109	doxorubicin	p53	MESH:D004317	22060(Tax:10090)	Chemical	Gene	efficacy|nmod|START_ENTITY enhance|dobj|efficacy Strategy|acl|enhance Strategy|dep|Involvement Involvement|nmod|receptor receptor|compound|END_ENTITY	Strategy to enhance efficacy of doxorubicin in solid tumor cells by methyl-b-cyclodextrin : Involvement of p53 and Fas receptor ligand complex .
7488003	0	doxorubicin	69,80	p53	43,46	doxorubicin	p53	MESH:D004317	7157	Chemical	Gene	treated|nmod|START_ENTITY cells|acl|treated attenuate|nmod|cells attenuate|dobj|expression expression|nmod|END_ENTITY	Phorbol_esters attenuate the expression of p53 in cells treated with doxorubicin and protect TS-P53 / K562 from apoptosis .
7729953	0	doxorubicin	31,42	p53	100,103	doxorubicin	p53	MESH:D004317	7157	Chemical	Gene	effects|nmod|START_ENTITY effects|acl|expressing expressing|dobj|END_ENTITY	Decreased cytotoxic effects of doxorubicin in a human ovarian_cancer-cell line expressing wild-type p53 and WAF1/CIP1 genes .
8187062	0	doxorubicin	41,52	p53	34,37	doxorubicin	p53	MESH:D004317	7157	Chemical	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|form form|nmod|END_ENTITY	Up-regulation of a mutant form of p53 by doxorubicin in human squamous_carcinoma cells .
9212237	0	doxorubicin	103,114	p53	133,136	doxorubicin	p53	MESH:D004317	7157	Chemical	Gene	selected|nmod|START_ENTITY line|acl|selected cisplatin|nmod|line Mechanism|acl|cisplatin Mechanism|dep|role role|nmod|END_ENTITY	Mechanism of resistance to cisplatin in a human ovarian-carcinoma cell line selected for resistance to doxorubicin : possible role of p53 .
7532928	0	doxorubicin	11,22	pp60c-src	26,35	doxorubicin	pp60c-src	MESH:D004317	20779(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effects of doxorubicin on pp60c-src kinase activity in polyoma virus MT antigen transformed cells .
15067340	0	doxorubicin	32,43	raf	112,115	doxorubicin	raf	MESH:D004317	22882	Chemical	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	Enhanced therapeutic effects of doxorubicin and paclitaxel in combination with liposome-entrapped ends-modified raf antisense oligonucleotide against human prostate , lung and breast_tumor models .
20359855	0	doxorubicin	100,111	somatostatin	18,30	doxorubicin	somatostatin	MESH:D004317	6750	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	The mechanisms of somatostatin induced enhanced chemosensitivity of gallbladder_cancer cell line to doxorubicin : cell cycle modulation plus target enzyme up-regulation .
9212777	0	doxorubicin	24,35	xanthine_dehydrogenase	39,61	doxorubicin	xanthine dehydrogenase	MESH:D004317	22436(Tax:10090)	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Reductive activation of doxorubicin by xanthine_dehydrogenase from EMT6 mouse mammary_carcinoma tumors .
23299796	0	doxorubicine	53,65	TNFa	9,13	doxorubicine	TNFa	CHEBI:28748	7124	Chemical	Gene	gene|nmod|START_ENTITY gene|nsubj|END_ENTITY	Systemic TNFa gene therapy synergizes with liposomal doxorubicine in the treatment of metastatic_cancer .
18315429	0	doxycycline	47,58	EMMPRIN	74,81	doxycycline	EMMPRIN	MESH:D004318	682	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	The effect of adjunctive subantimicrobial dose doxycycline therapy on GCF EMMPRIN levels in chronic_periodontitis .
18339571	0	doxycycline	70,81	FOXP3	95,100	doxycycline	FOXP3	MESH:D004318	50943	Chemical	Gene	+|amod|START_ENTITY +|compound|END_ENTITY	Natural death of adult Onchocerca_volvulus and filaricidal effects of doxycycline induce local FOXP3 + / CD4 + regulatory T cells and granzyme expression .
11914015	0	doxycycline	150,161	MMP-2	17,22	doxycycline	MMP-2	MESH:D004318	81686(Tax:10116)	Chemical	Gene	leads|xcomp|START_ENTITY leads|nsubj|Up-regulation Up-regulation|nmod|END_ENTITY	Up-regulation of MMP-2 and MMP-9 leads to degradation of type IV collagen during skeletal muscle reperfusion_injury ; protection by the MMP inhibitor , doxycycline .
19442784	0	doxycycline	11,22	MMP-2	58,63	doxycycline	MMP-2	MESH:D004318	4313	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of doxycycline on serum and endometrial levels of MMP-2 , MMP-9 and TIMP-1 in women using a levonorgestrel-releasing subcutaneous implant .
19516001	12	doxycycline	1509,1520	MMP-2	1465,1470	doxycycline	MMP-9	MESH:D004318	4318	Chemical	Gene	declined|nmod|START_ENTITY declined|nsubj|activities activities|nmod|END_ENTITY	However , the in vitro enzymatic activities of purified MMP-2 and MMP-9 declined significantly with doxycycline .
15667660	0	doxycycline	24,35	MMP-9	15,20	doxycycline	MMP-9	MESH:D004318	4318	Chemical	Gene	Suppression|nmod|START_ENTITY Suppression|nmod|END_ENTITY	Suppression of MMP-9 by doxycycline in brain_arteriovenous_malformations .
10048390	0	doxycycline	39,50	erythropoietin	11,25	doxycycline	erythropoietin	MESH:D004318	13856(Tax:10090)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Control Control|nmod|END_ENTITY	Control of erythropoietin secretion by doxycycline or mifepristone in mice bearing polymer-encapsulated engineered cells .
9055857	0	doxycycline	49,60	erythropoietin	21,35	doxycycline	erythropoietin	MESH:D004318	13856(Tax:10090)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Long-term control of erythropoietin secretion by doxycycline in mice transplanted with engineered primary myoblasts .
9716577	0	doxycycline	38,49	erythropoietin	11,25	doxycycline	erythropoietin	MESH:D004318	13856(Tax:10090)	Chemical	Gene	Control|nmod|START_ENTITY Control|nmod|delivery delivery|compound|END_ENTITY	Control of erythropoietin delivery by doxycycline in mice after intramuscular injection of adeno-associated vector .
14681644	0	doxycycline	68,79	matrix_metalloproteinase-2	27,53	doxycycline	matrix metalloproteinase-2	MESH:D004318	4313	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Mechanism of inhibition of matrix_metalloproteinase-2 expression by doxycycline in human aortic smooth muscle cells .
19364980	0	doxycycline	112,123	matrix_metalloproteinase-9	34,60	doxycycline	matrix metalloproteinase-9	MESH:D004318	4318	Chemical	Gene	patients|nmod|START_ENTITY inhibition|nmod|patients inhibition|amod|END_ENTITY	Clinical trial of doxycycline for matrix_metalloproteinase-9 inhibition in patients with an abdominal_aneurysm : doxycycline selectively depletes aortic wall neutrophils and cytotoxic T cells .
19364980	0	doxycycline	18,29	matrix_metalloproteinase-9	34,60	doxycycline	matrix metalloproteinase-9	MESH:D004318	4318	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|amod|END_ENTITY	Clinical trial of doxycycline for matrix_metalloproteinase-9 inhibition in patients with an abdominal_aneurysm : doxycycline selectively depletes aortic wall neutrophils and cytotoxic T cells .
21420951	0	doxycycline	53,64	matrix_metalloproteinase-9	14,40	doxycycline	matrix metalloproteinase-9	MESH:D004318	17395(Tax:10090)	Chemical	Gene	ameliorates|amod|START_ENTITY activity|nmod|ameliorates activity|amod|END_ENTITY	Inhibition of matrix_metalloproteinase-9 activity by doxycycline ameliorates RANK ligand-induced osteoclast differentiation in vitro and in vivo .
19052856	0	doxycycline	22,33	matrix_metalloproteinases_2_and_9	37,70	doxycycline	matrix metalloproteinases 2 and 9	MESH:D004318	4313;4318	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Short term effects of doxycycline on matrix_metalloproteinases_2_and_9 .
24637538	0	drebrin	19,26	cyclin-dependent_kinase_5	30,55	drebrin	cyclin-dependent kinase 5	null	12568(Tax:10090)	Chemical	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of drebrin by cyclin-dependent_kinase_5 and its role in neuronal migration .
8769857	0	drebrin	14,21	fascin	62,68	drebrin	fascin	null	683788(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	Inhibition by drebrin of the actin-bundling activity of brain fascin , a protein localized in filopodia of growth cones .
11742585	0	droloxifene	21,32	Bcl-2	49,54	droloxifene	Bcl-2	MESH:C038345	24224(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Apoptosis induced by droloxifene and C-myc , Bax , Bcl-2 protein expression in corpus luteum of pregnant rats .
11104825	0	droloxifene	21,32	bax	44,47	droloxifene	bax	MESH:C038345	24887(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Apoptosis induced by droloxifene and c-myc , bax and bcl-2 mRNA expression in cultured luteal cells of rats .
1835818	0	droloxifene	66,77	transforming_growth_factor_beta	13,44	droloxifene	transforming growth factor beta	MESH:C038345	7040	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of transforming_growth_factor_beta by the antiestrogens droloxifene , tamoxifen , and toremifene in MCF-7 cells .
24980665	0	dulaglutide	68,79	glucagon-like_peptide-1_receptor	27,59	dulaglutide	glucagon-like peptide-1 receptor	null	2740	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|agonist agonist|amod|END_ENTITY	Effects of the once-weekly glucagon-like_peptide-1_receptor agonist dulaglutide on ambulatory blood pressure and heart rate in patients with type_2_diabetes_mellitus .
25100382	0	duloxetine	88,98	chromogranin_A	10,24	duloxetine	chromogranin A	MESH:C058218	1113	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|END_ENTITY	Increased chromogranin_A and carcinoid_syndrome-like_symptoms in a patient treated with duloxetine .
18307373	0	duloxetine	74,84	cytochrome_P450_1A2	36,55	duloxetine	cytochrome P450 1A2	MESH:C058218	1544	Chemical	Gene	interactions|nmod|START_ENTITY interactions|amod|END_ENTITY	In vitro and in vivo evaluations of cytochrome_P450_1A2 interactions with duloxetine .
12350480	0	dutasteride	76,87	5-alpha-reductase	43,60	dutasteride	5-alpha-reductase	MESH:C108373	6715	Chemical	Gene	1|appos|START_ENTITY Efficacy|dep|1 Efficacy|nmod|inhibitor inhibitor|nmod|types types|amod|END_ENTITY	Efficacy and safety of a dual inhibitor of 5-alpha-reductase types 1 and 2 -LRB- dutasteride -RRB- in men with benign_prostatic_hyperplasia .
23280489	0	dutasteride	97,108	5-alpha-reductase	68,85	dutasteride	5-alpha-reductase	MESH:C108373	6715	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Mode of action of human pharmaceuticals in fish : the effects of the 5-alpha-reductase inhibitor , dutasteride , on reproduction as a case study .
17295600	0	dutasteride	146,157	5-alpha_reductase	116,133	dutasteride	5-alpha reductase	MESH:C108373	6715	Chemical	Gene	analysis|dep|START_ENTITY analysis|nmod|retention retention|nmod|patients patients|acl|treated treated|nmod|inhibitors inhibitors|amod|END_ENTITY	A large retrospective analysis of acute urinary retention and prostate-related surgery in BPH patients treated with 5-alpha_reductase inhibitors : dutasteride versus finasteride .
16703599	0	dutasteride	48,59	5_alpha-reductase	20,37	dutasteride	5 alpha-reductase	MESH:C108373	6715	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Effects of the dual 5_alpha-reductase inhibitor dutasteride on apoptosis in primary cultures of prostate_cancer epithelial cells and cell lines .
12814679	0	dutasteride	63,74	5alpha-reductase	36,52	dutasteride	5alpha-reductase	MESH:C108373	6715	Chemical	Gene	START_ENTITY|nsubj|Safety Safety|nmod|inhibitor inhibitor|amod|END_ENTITY	Safety and tolerability of the dual 5alpha-reductase inhibitor dutasteride in the treatment of benign_prostatic_hyperplasia .
12887480	0	dutasteride	75,86	5alpha-reductase	103,119	dutasteride	5alpha-reductase	MESH:C108373	6715	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Improvements in benign_prostatic_hyperplasia-specific quality of life with dutasteride , the novel dual 5alpha-reductase inhibitor .
15126539	0	dutasteride	86,97	5alpha-reductase	106,122	dutasteride	5alpha-reductase	MESH:C108373	6715	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Marked suppression of dihydrotestosterone in men with benign_prostatic_hyperplasia by dutasteride , a dual 5alpha-reductase inhibitor .
15310997	0	dutasteride	46,57	5alpha-reductase	19,35	dutasteride	5alpha-reductase	MESH:C108373	6715	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|inhibitor inhibitor|amod|END_ENTITY	Effect of the dual 5alpha-reductase inhibitor dutasteride on markers of tumor regression in prostate_cancer .
16719800	0	dutasteride	38,49	5alpha-reductase	65,81	dutasteride	5alpha-reductase	MESH:C108373	6715	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Discovery and clinical development of dutasteride , a potent dual 5alpha-reductase inhibitor .
16983393	0	dutasteride	66,77	5alpha-reductase	38,54	dutasteride	5alpha-reductase	MESH:C108373	6715	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Efficacy and tolerability of the dual 5alpha-reductase inhibitor , dutasteride , in the treatment of benign_prostatic_hyperplasia in African-American men .
17110217	0	dutasteride	147,158	5alpha-reductase	23,39	dutasteride	5alpha-reductase	MESH:C108373	6715	Chemical	Gene	study|nmod|START_ENTITY results|nmod|study importance|dep|results importance|nmod|inhibition inhibition|amod|END_ENTITY	The importance of dual 5alpha-reductase inhibition in the treatment of male pattern hair loss : results of a randomized placebo-controlled study of dutasteride versus finasteride .
17299062	0	dutasteride	47,58	5alpha-reductase	14,30	dutasteride	5alpha-reductase	MESH:C108373	6715	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	The effect of 5alpha-reductase inhibition with dutasteride and finasteride on semen parameters and serum hormones in healthy men .
18423697	0	dutasteride	47,58	5alpha-reductase	14,30	dutasteride	5alpha-reductase	MESH:C108373	6715	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	The effect of 5alpha-reductase inhibition with dutasteride and finasteride on bone mineral density , serum lipoproteins , hemoglobin , prostate_specific_antigen and sexual function in healthy young men .
18588452	0	dutasteride	94,105	5alpha-reductase	66,82	dutasteride	5alpha-reductase	MESH:C108373	6715	Chemical	Gene	START_ENTITY|nsubj|trial trial|dep|chemoprevention chemoprevention|nmod|prostate_cancer prostate_cancer|acl|using using|dobj|inhibitor inhibitor|amod|END_ENTITY	The REDUCE trial : chemoprevention in prostate_cancer using a dual 5alpha-reductase inhibitor , dutasteride .
25707134	0	dutasteride	22,33	Claudin1	67,75	dutasteride	Claudin1	MESH:C108373	65129(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expressions expressions|nmod|END_ENTITY	-LSB- Inhibitory effect of dutasteride on the expressions of epididymal Claudin1 and b-catenin in male rats -RSB- .
23813737	0	dutasteride	32,43	androgen_receptor	62,79	dutasteride	androgen receptor	MESH:C108373	367	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	The direct inhibitory effect of dutasteride or finasteride on androgen_receptor activity is cell line specific .
21161049	0	dynorphin_A	10,21	IFN-y	62,67	dynorphin A	IFN-y	MESH:D004399	3458	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of dynorphin_A -LRB- 1-17 -RRB- on proliferation and IL-2 , IL-4 , IFN-y production by peripheral blood mononuclears .
21161049	0	dynorphin_A	10,21	IL-4	56,60	dynorphin A	IL-4	MESH:D004399	3565	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of dynorphin_A -LRB- 1-17 -RRB- on proliferation and IL-2 , IL-4 , IFN-y production by peripheral blood mononuclears .
12606694	0	dynorphin_A	106,117	kappa_opioid_receptor	37,58	dynorphin A	kappa opioid receptor	MESH:D004399	4986	Chemical	Gene	internalization|amod|START_ENTITY reduced|dobj|internalization reduced|nsubj|regulation regulation|nmod|END_ENTITY	Differential regulation of the human kappa_opioid_receptor by agonists : etorphine and levorphanol reduced dynorphin_A - and U50,488H-induced internalization and phosphorylation .
18487043	0	dynorphin_A	80,91	kappa_opioid_receptor	114,135	dynorphin A	kappa opioid receptor	MESH:D004399	4986	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Use of receptor chimeras to identify small molecules with high affinity for the dynorphin_A binding domain of the kappa_opioid_receptor .
9045702	2	dynorphin_B	157,168	prodynorphin	125,137	dynorphin B	prodynorphin	MESH:C036200	101839546	Chemical	Gene	stimulation|nmod|START_ENTITY stimulation|nmod|expression expression|amod|END_ENTITY	Autocrine stimulation of prodynorphin gene expression by dynorphin_B .
11752129	0	ebastine	55,63	CYP2J2	15,21	ebastine	CYP2J2	MESH:C058249	1573	Chemical	Gene	metabolism|nmod|START_ENTITY Involvement|nmod|metabolism Involvement|nmod|END_ENTITY	Involvement of CYP2J2 and CYP4F12 in the metabolism of ebastine in human intestinal microsomes .
14737963	0	ebelactone_B	11,23	cathepsin_A	27,38	ebelactone B	cathepsin A	MESH:C030795	5476	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|compound|END_ENTITY	Effects of ebelactone_B on cathepsin_A activity in intact platelets and on platelet activation .
8835930	0	ebelactone_B	11,23	lipase	27,33	ebelactone B	lipase	MESH:C030795	291437(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effects of ebelactone_B , a lipase inhibitor , on intestinal fat absorption in the rat .
8147899	0	ebselen	15,22	glutathione_S-transferase	28,53	ebselen	glutathione S-transferase	MESH:C042986	58962(Tax:10116)	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of ebselen with glutathione_S-transferase and papain in vitro .
17559913	0	ecallantide	87,98	kallikrein	108,118	ecallantide	kallikrein	MESH:C511194	9622	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Critical role of kallikrein in hereditary_angioedema pathogenesis : a clinical trial of ecallantide , a novel kallikrein inhibitor .
17559913	0	ecallantide	87,98	kallikrein	17,27	ecallantide	kallikrein	MESH:C511194	9622	Chemical	Gene	trial|nmod|START_ENTITY role|dep|trial role|nmod|END_ENTITY	Critical role of kallikrein in hereditary_angioedema pathogenesis : a clinical trial of ecallantide , a novel kallikrein inhibitor .
8544820	0	ecdysone	69,77	Lsp-2	111,116	ecdysone	Lsp-2	MESH:D004440	45326(Tax:7227)	Chemical	Gene	responsiveness|amod|START_ENTITY responsiveness|nmod|gene gene|compound|END_ENTITY	Characterization of an EcR/USP heterodimer target site that mediates ecdysone responsiveness of the Drosophila Lsp-2 gene .
8887683	0	ecdysone	61,69	hsp23	97,102	ecdysone	hsp23	MESH:D004440	39077(Tax:7227)	Chemical	Gene	response|amod|START_ENTITY response|nmod|gene gene|amod|END_ENTITY	The Broad-Complex gene is a tissue-specific modulator of the ecdysone response of the Drosophila hsp23 gene .
10528406	0	ecdysteroid	19,30	Insulin	0,7	ecdysteroid	Insulin	MESH:D026461	3630	Chemical	Gene	START_ENTITY|nsubj|stimulates stimulates|compound|END_ENTITY	Insulin stimulates ecdysteroid production through a conserved signaling cascade in the mosquito Aedes_aegypti .
15936331	0	ecdysteroid	36,47	betaFTZ-F1	11,21	ecdysteroid	betaFTZ-F1	MESH:D026461	40045(Tax:7227)	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	A role for betaFTZ-F1 in regulating ecdysteroid titers during post-embryonic development in Drosophila_melanogaster .
11222944	0	ecdysteroid	136,147	prothoracicotropic_hormone	44,70	ecdysteroid	prothoracicotropic hormone	MESH:D026461	692767(Tax:7091)	Chemical	Gene	secretion|amod|START_ENTITY correlation|nmod|secretion profile|dep|correlation profile|nmod|changes changes|nmod|titer titer|amod|END_ENTITY	Developmental profile of the changes in the prothoracicotropic_hormone titer in hemolymph of the silkworm Bombyx_mori : correlation with ecdysteroid secretion .
25596092	0	ecdysteroid	72,83	prothoracicotropic_hormone	32,58	ecdysteroid	prothoracicotropic hormone	MESH:D026461	692767(Tax:7091)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|amod|END_ENTITY	Positive feedback regulation of prothoracicotropic_hormone secretion by ecdysteroid - A mechanism that determines the timing of metamorphosis .
6800787	0	ecdysterone	23,34	Catalase	0,8	ecdysterone	Catalase	MESH:D004441	40048(Tax:7227)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Catalase is induced by ecdysterone and ethanol in Drosophila cells .
22500399	0	ecdysterone	12,23	NF-kappaB_p65	45,58	ecdysterone	NF-kappaB p65	MESH:D004441	5970	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of ecdysterone on the expression of NF-kappaB_p65 in H2O2 induced oxidative damage of human lens epithelial cells -RSB- .
15303649	0	ecdysterone	11,22	c-fos	44,49	ecdysterone	c-fos	MESH:D004441	314322(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of ecdysterone on the expression of c-fos in the brain of rats induced by microinjection beta-AP25-35 into the hippocampus -RSB- .
8571328	0	echicetin	15,24	thrombin	46,54	echicetin	thrombin	MESH:C080995	2147	Chemical	Gene	Interaction|nmod|START_ENTITY END_ENTITY|nsubj|Interaction	Interaction of echicetin with a high affinity thrombin binding site on platelet glycoprotein GPIb .
19258277	0	echinocandin	31,43	Fks1	9,13	echinocandin	Fks1	CHEBI:57248	851055(Tax:4932)	Chemical	Gene	resistance|compound|START_ENTITY END_ENTITY|nmod|resistance	Role for Fks1 in the intrinsic echinocandin resistance of Fusarium_solani as evidenced by hybrid expression in Saccharomyces_cerevisiae .
19678540	0	echinocystic_acid	44,61	interleukin-18	4,18	echinocystic acid	interleukin-18	MESH:C022999	3606	Chemical	Gene	activities|nmod|START_ENTITY activities|amod|END_ENTITY	The interleukin-18 inhibitory activities of echinocystic_acid and its saponins from Impatiens pritzellii var .
22874467	0	echinomycin	11,22	endothelin-2	26,38	echinomycin	endothelin-2	MESH:D004448	24324(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|amod|END_ENTITY	Effects of echinomycin on endothelin-2 expression and ovulation in immature rats primed with gonadotropins .
17916190	0	echinomycin	15,26	hypoxia-inducible_factor-1	30,56	echinomycin	hypoxia-inducible factor-1	MESH:D004448	3091	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|amod|END_ENTITY	Dual effect of echinomycin on hypoxia-inducible_factor-1 activity under normoxic and hypoxic conditions .
26654708	0	echinomycin	52,63	vascular_endothelial_growth_factor	67,101	echinomycin	vascular endothelial growth factor	MESH:D004448	7422	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Effects of the hypoxia-inducible factor-1 inhibitor echinomycin on vascular_endothelial_growth_factor production and apoptosis in human ectopic endometriotic stromal cells .
19931411	0	eckol	62,67	heme_oxygenase-1	31,47	eckol	heme oxygenase-1	MESH:C060311	100756872	Chemical	Gene	Nrf2-mediated|nmod|START_ENTITY Nrf2-mediated|dobj|expression expression|amod|END_ENTITY	Up-regulation of Nrf2-mediated heme_oxygenase-1 expression by eckol , a phlorotannin compound , through activation of Erk and PI3K/Akt .
25268719	0	eckol	0,5	heme_oxygenase-1	15,31	eckol	heme oxygenase-1	MESH:C060311	3162	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	eckol enhances heme_oxygenase-1 expression through activation of Nrf2/JNK pathway in HepG2 cells .
10903961	0	econazole	38,47	cytochrome_P-450	10,26	econazole	cytochrome P-450	MESH:D004464	13079(Tax:10090)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Effect of cytochrome_P-450 inhibitors econazole , bifonazole and clotrimazole on prostanoid formation .
23818943	0	ecosystem_carbon	51,67	CO2	20,23	ecosystem carbon	CO2	null	717	Chemical	Gene	fluxes|compound|START_ENTITY END_ENTITY|nmod|fluxes	Effects of elevated CO2 and nitrogen deposition on ecosystem_carbon fluxes on the Sanjiang plain wetland in Northeast China .
11850153	0	ecstasy	40,47	5-HT2A	62,68	ecstasy	5-HT2A	null	29595(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|receptors receptors|amod|END_ENTITY	The acute and chronic effects of MDMA -LRB- `` ecstasy '' -RRB- on cortical 5-HT2A receptors in rat and human brain .
16574714	0	ecstasy	69,76	Vasopressin	0,11	ecstasy	Vasopressin	null	551	Chemical	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Vasopressin and oxytocin secretion in response to the consumption of ecstasy in a clubbing population .
10621770	0	ecstasy	86,93	serotonin_transporter	31,52	ecstasy	serotonin transporter	null	6532	Chemical	Gene	binding|dep|START_ENTITY binding|nmod|END_ENTITY	Reduced in vivo binding to the serotonin_transporter in the cerebral cortex of MDMA -LRB- ` ecstasy ' -RRB- users .
9694721	0	ecto-nicotinamide_adenine_dinucleotide	23,61	CD38	77,81	ecto-nicotinamide adenine dinucleotide	CD38	null	12494(Tax:10090)	Chemical	Gene	exhibit|amod|START_ENTITY exhibit|compound|END_ENTITY	Mice deficient for the ecto-nicotinamide_adenine_dinucleotide glycohydrolase CD38 exhibit altered humoral immune responses .
23916596	1	ectoine	93,100	lon	104,107	ectoine	lon	CHEBI:27592	9361	Chemical	Gene	START_ENTITY|nmod|level level|compound|END_ENTITY	strain C-2012 and the effect of salt and ectoine on lon expression level .
24849726	0	edaravone	65,74	5-lipoxygenase	36,50	edaravone	5-lipoxygenase	MESH:C005435	11689(Tax:10090)	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Suppression of oxidative_stress and 5-lipoxygenase activation by edaravone improves depressive-like behavior after concussion .
21429313	0	edaravone	12,21	GRP78	43,48	edaravone	GRP78	MESH:C005435	25617(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of edaravone on the expression of GRP78 , Caspase-12 , and neuron apoptosis in juvenile rat hippocampus after status convulsive -RSB- .
26309693	0	edaravone	10,19	SP-A	29,33	edaravone	SP-A	MESH:C005435	653509	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of edaravone on serum SP-A and arterial blood gas in patients with lobectomy .
21426644	0	edaravone	12,21	glial_fibrillary_acidic_protein	25,56	edaravone	glial fibrillary acidic protein	MESH:C005435	24387(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	-LSB- Effects of edaravone on glial_fibrillary_acidic_protein and interleukin-lb expression and neuronal apoptosis in juvenile rat hippocampus after status convulsion -RSB- .
24739406	0	edaravone	22,31	matrix_metalloproteinase-9	59,85	edaravone	matrix metalloproteinase-9	MESH:C005435	4318	Chemical	Gene	effects|nmod|START_ENTITY effects|amod|END_ENTITY	Beneficial effects of edaravone on the expression of serum matrix_metalloproteinase-9 after cerebral_hemorrhage .
24820542	0	edaravone	20,29	matrix_metalloproteinase-9	39,65	edaravone	matrix metalloproteinase-9	MESH:C005435	17395(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|upregulation upregulation|amod|END_ENTITY	A radical scavenger edaravone inhibits matrix_metalloproteinase-9 upregulation and blood-brain barrier breakdown in a mouse model of prolonged cerebral_hypoperfusion .
19944317	0	edaravone	10,19	monocyte_chemoattractant_protein-1	30,64	edaravone	monocyte chemoattractant protein-1	MESH:C005435	6347	Chemical	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Effect of edaravone on plasma monocyte_chemoattractant_protein-1 levels in patients with acute_myocardial_infarction .
17965547	0	edaravone	23,32	p53	76,79	edaravone	p53	MESH:C005435	7157	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|inhibition inhibition|compound|END_ENTITY	Free radical scavenger edaravone suppresses x-ray-induced apoptosis through p53 inhibition in MOLT-4 cells .
21967833	0	edaravone	18,27	t-PA	62,66	edaravone	t-PA	MESH:C005435	5327	Chemical	Gene	START_ENTITY|nmod|infusion infusion|amod|END_ENTITY	Administration of edaravone , a free radical scavenger , during t-PA infusion can enhance early recanalization in acute_stroke patients -- a preliminary study .
16550312	0	edaravone	22,31	tumor_necrosis_factor-alpha	53,80	edaravone	tumor necrosis factor-alpha	MESH:C005435	24835(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Inhibitory effects of edaravone on the production of tumor_necrosis_factor-alpha in the isolated heart undergoing ischemia and reperfusion .
26615420	0	edelfosine	26,36	death_receptor_5	103,119	edelfosine	death receptor 5	MESH:C026659	8795	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	The alkyllysophospholipid edelfosine enhances TRAIL-mediated apoptosis in gastric_cancer cells through death_receptor_5 and the mitochondrial pathway .
20807664	0	edoxaban	44,52	Factor_Xa	23,32	edoxaban	Factor Xa	MESH:C552171	2159	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Comparison of a direct Factor_Xa inhibitor , edoxaban , with dalteparin and ximelagatran : a randomised controlled trial in healthy elderly adults .
24947287	0	edoxaban	81,89	Factor_Xa	138,147	edoxaban	Factor Xa	MESH:C552171	2159	Chemical	Gene	START_ENTITY|nmod|warfarin warfarin|dep|Anticoagulation Anticoagulation|nmod|Generation Generation|compound|END_ENTITY	Cerebrovascular events in 21 105 patients with atrial_fibrillation randomized to edoxaban versus warfarin : Effective Anticoagulation with Factor_Xa Next Generation in Atrial_Fibrillation-Thrombolysis in Myocardial_Infarction 48 .
26345573	0	edoxaban	75,83	Factor_Xa	54,63	edoxaban	Factor Xa	MESH:C552171	2159	Chemical	Gene	treatment|acl|START_ENTITY treatment|nmod|venous_thromboembolism venous_thromboembolism|nmod|inhibitor inhibitor|compound|END_ENTITY	Successful treatment of venous_thromboembolism with a Factor_Xa inhibitor , edoxaban , in patients with lenalidomide-treated multiple_myeloma .
26345573	0	edoxaban	75,83	Factor_Xa	54,63	edoxaban	Factor Xa	MESH:C552171	2159	Chemical	Gene	treatment|acl|START_ENTITY treatment|nmod|venous_thromboembolism venous_thromboembolism|nmod|inhibitor inhibitor|compound|END_ENTITY	Successful treatment of venous_thromboembolism with a Factor_Xa inhibitor , edoxaban , in patients with lenalidomide-treated multiple_myeloma .
26386790	0	edoxaban	99,107	Factor_Xa	169,178	edoxaban	Factor Xa	MESH:C552171	2159	Chemical	Gene	randomized|nmod|START_ENTITY atrial_fibrillation|acl|randomized patients|nmod|atrial_fibrillation embolism|nmod|patients embolism|dep|Results Results|nmod|Anticoagulation Anticoagulation|nmod|Generation Generation|compound|END_ENTITY	Systemic , noncerebral , arterial embolism in 21,105 patients with atrial_fibrillation randomized to edoxaban or warfarin : Results from the Effective Anticoagulation With Factor_Xa Next Generation in Atrial_Fibrillation-Thrombolysis in Myocardial_Infarction Study 48 trial .
20589317	0	edoxaban	38,46	factor_Xa	12,21	edoxaban	factor Xa	MESH:C552171	2159	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|END_ENTITY	Oral direct factor_Xa inhibition with edoxaban for thromboprophylaxis after elective total hip replacement .
20694273	0	edoxaban	79,87	factor_Xa	97,106	edoxaban	factor Xa	MESH:C552171	2159	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Randomised , parallel-group , multicentre , multinational phase 2 study comparing edoxaban , an oral factor_Xa inhibitor , with warfarin for stroke prevention in patients with atrial_fibrillation .
21136011	0	edoxaban	10,18	factor_Xa	28,37	edoxaban	factor Xa	MESH:C552171	2159	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Safety of edoxaban , an oral factor_Xa inhibitor , in Asian patients with non-valvular atrial_fibrillation .
22924409	0	edoxaban	75,83	factor_Xa	93,102	edoxaban	factor Xa	MESH:C552171	2159	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY trial|appos|pharmacokinetics trial|appos|inhibitor inhibitor|compound|END_ENTITY	A randomized trial of the safety , pharmacokinetics and pharmacodynamics of edoxaban , an oral factor_Xa inhibitor , following a switch from warfarin .
23064240	0	edoxaban	51,59	factor_Xa	31,40	edoxaban	factor Xa	MESH:C552171	2159	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|Pharmacokinetics Pharmacokinetics|nmod|END_ENTITY	Pharmacokinetics of the direct factor_Xa inhibitor edoxaban and digoxin administered alone and in combination .
23615159	0	edoxaban	124,132	factor_Xa	143,152	edoxaban	factor Xa	MESH:C552171	2159	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY inhibitor|nmod|pharmacokinetics inhibitor|nsubj|END_ENTITY	The effects of the antiplatelet agents , aspirin and naproxen , on pharmacokinetics and pharmacodynamics of the anticoagulant edoxaban , a direct factor_Xa inhibitor .
23784266	0	edoxaban	130,138	factor_Xa	148,157	edoxaban	factor Xa	MESH:C552171	2159	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Drug-drug interaction studies of cardiovascular drugs involving P-glycoprotein , an efflux transporter , on the pharmacokinetics of edoxaban , an oral factor_Xa inhibitor .
26560872	0	edoxaban	27,35	factor_Xa	7,16	edoxaban	factor Xa	MESH:C552171	2159	Chemical	Gene	START_ENTITY|nsubj|inhibitor inhibitor|compound|END_ENTITY	Direct factor_Xa inhibitor edoxaban : from bench to clinical practice .
20934556	0	edoxaban	44,52	factor_xA	174,183	edoxaban	factor xA	MESH:C552171	2159	Chemical	Gene	Evaluation|nmod|START_ENTITY Evaluation|dep|design design|nmod|aNticoaGulation aNticoaGulation|nmod|GEneration GEneration|amod|END_ENTITY	Evaluation of the novel factor_Xa inhibitor edoxaban compared with warfarin in patients with atrial_fibrillation : design and rationale for the Effective aNticoaGulation with factor_xA next GEneration in Atrial Fibrillation-Thrombolysis In Myocardial_Infarction study 48 -LRB- ENGAGE AF-TIMI 48 -RRB- .
16945334	0	efaroxan	57,65	Rhes	0,4	efaroxan	Rhes	MESH:C062597	23551	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	Rhes expression in pancreatic beta-cells is regulated by efaroxan in a calcium-dependent process .
22570147	0	efatutazone	19,30	peroxisome_proliferator-activated_receptor_gamma	40,88	efatutazone	peroxisome proliferator-activated receptor gamma	MESH:C510342	5468	Chemical	Gene	study|nmod|START_ENTITY study|appos|agonist agonist|amod|END_ENTITY	A phase 1 study of efatutazone , an oral peroxisome_proliferator-activated_receptor_gamma agonist , administered to patients with advanced malignancies .
24337768	0	efatutazone	17,28	peroxisome_proliferator-activated_receptor_gamma	43,91	efatutazone	peroxisome proliferator-activated receptor gamma	MESH:C510342	5468	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Phase 1 study of efatutazone , a novel oral peroxisome_proliferator-activated_receptor_gamma agonist , in combination with FOLFIRI as second-line therapy in patients with metastatic colorectal_cancer .
22327	0	ehtanol	34,41	catalase	51,59	ehtanol	catalase	null	24248(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Tritium effect in peroxidation of ehtanol by liver catalase .
2106713	0	eicosanoid	24,34	luteinizing_hormone-releasing_hormone	61,98	eicosanoid	luteinizing hormone-releasing hormone	CHEBI:23899	25194(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY release|amod|END_ENTITY	Effect of castration on eicosanoid and catecholamine-induced luteinizing_hormone-releasing_hormone release in vitro .
26686860	0	eicosanoids	57,68	12/15-lipoxygenase	12,30	eicosanoids	12/15-lipoxygenase	MESH:D015777	11687(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of 12/15-lipoxygenase in production of selected eicosanoids in allergic airway_inflammation .
8287433	0	eicosanoids	32,43	atrial_natriuretic_factor	58,83	eicosanoids	atrial natriuretic factor	MESH:D015777	24602(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of ischaemia and role of eicosanoids in release of atrial_natriuretic_factor from rat heart .
8448018	0	eicosanoids	14,25	endothelin-1	41,53	eicosanoids	endothelin-1	MESH:D015777	1906	Chemical	Gene	Production|nmod|START_ENTITY Production|nmod|END_ENTITY	Production of eicosanoids in response to endothelin-1 and identification of specific endothelin-1 binding sites in airway epithelial cells .
9252095	0	eicosanoids	11,22	ornithine_decarboxylase	53,76	eicosanoids	ornithine decarboxylase	MESH:D015777	18263(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|compound|END_ENTITY	Effects of eicosanoids on lipopolysaccharide-induced ornithine_decarboxylase activity and polyamine metabolism in the mouse liver .
16221546	0	eicosapentaenoic_acid	8,29	CTLA-4	40,46	eicosapentaenoic acid	CTLA-4	MESH:D015118	12477(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|expression expression|compound|END_ENTITY	Dietary eicosapentaenoic_acid modulates CTLA-4 expression in murine CD4 + T-cells .
21118482	0	eicosapentaenoic_acid	19,40	HMGCoA_reductase	78,94	eicosapentaenoic acid	HMGCoA reductase	MESH:D015118	3156	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|nmod|END_ENTITY	Synergic effect of eicosapentaenoic_acid and lovastatin on gene expression of HMGCoA_reductase and LDL_receptor in cultured HepG2 cells .
12573452	0	eicosapentaenoic_acid	14,35	PGHS-2	56,62	eicosapentaenoic acid	PGHS-2	MESH:D015118	5743	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Inhibition by eicosapentaenoic_acid of IL-1beta-induced PGHS-2 expression in human microvascular endothelial cells : involvement of lipoxygenase-derived metabolites and p38 MAPK pathway .
17569885	0	eicosapentaenoic_acid	51,72	adiponectin	10,21	eicosapentaenoic acid	adiponectin	MESH:D015118	9370	Chemical	Gene	START_ENTITY|nsubj|secretion secretion|compound|END_ENTITY	Increased adiponectin secretion by highly purified eicosapentaenoic_acid in rodent models of obesity and human obese subjects .
22912426	0	eicosapentaenoic_acid	16,37	interleukin-10	48,62	eicosapentaenoic acid	interleukin-10	MESH:D015118	3586	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|amod|END_ENTITY	Highly purified eicosapentaenoic_acid increases interleukin-10 levels of peripheral blood monocytes in obese patients with dyslipidemia .
23801810	1	eicosapentaenoic_acid	49,70	interleukin-10	81,95	eicosapentaenoic acid	interleukin-10	MESH:D015118	3586	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|amod|END_ENTITY	Highly purified eicosapentaenoic_acid increases interleukin-10 levels of peripheral blood monocytes in obese patients with dyslipidemia .
23801811	1	eicosapentaenoic_acid	61,82	interleukin-10	93,107	eicosapentaenoic acid	interleukin-10	MESH:D015118	3586	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|amod|END_ENTITY	Highly purified eicosapentaenoic_acid increases interleukin-10 levels of peripheral blood monocytes in obese patients with dyslipidemia .
9059324	0	eicosapentaenoic_acid	103,124	interleukin-6	156,169	eicosapentaenoic acid	interleukin-6	MESH:D015118	3569	Chemical	Gene	receiving|dobj|START_ENTITY pancreatic_cancer_cachexia|acl|receiving patients|nmod|pancreatic_cancer_cachexia response|nmod|patients Down-regulation|nmod|response mediated|nsubjpass|Down-regulation mediated|nmod|suppression suppression|nmod|END_ENTITY	Down-regulation of the acute-phase response in patients with pancreatic_cancer_cachexia receiving oral eicosapentaenoic_acid is mediated via suppression of interleukin-6 .
16724678	0	eicosapentaenoic_acid	14,35	prostate-specific_antigen	39,64	eicosapentaenoic acid	prostate-specific antigen	MESH:D015118	354	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of eicosapentaenoic_acid on prostate-specific_antigen .
12401440	0	eicosapentaenoic_acid	22,43	tyrosine_kinase	87,102	eicosapentaenoic acid	tyrosine kinase	MESH:D015118	7294	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activation activation|compound|END_ENTITY	Inhibitory effects of eicosapentaenoic_acid -LRB- EPA -RRB- on the hypoxia/reoxygenation-induced tyrosine_kinase activation in cultured human umbilical vein endothelial cells .
18755047	0	eicosapentaenoic_acid_ethyl_ester	11,44	visfatin	48,56	eicosapentaenoic acid ethyl ester	visfatin	MESH:C035276	297508(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of eicosapentaenoic_acid_ethyl_ester on visfatin and apelin in lean and overweight -LRB- cafeteria diet-fed -RRB- rats .
17321792	0	elaidic_acid	42,54	caspase_3	14,23	elaidic acid	caspase 3	MESH:C011459	836	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of caspase_3 in HepG2 cells by elaidic_acid -LRB- t18 :1 -RRB- .
10708549	0	elcatonin	10,19	bone_morphogenetic_protein-2	59,87	elcatonin	bone morphogenetic protein-2	MESH:C012755	650	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of elcatonin on osteoinduction by recombinant human bone_morphogenetic_protein-2 .
27073515	0	elemene	25,32	GSTP1	40,45	elemene	GSTP1	MESH:C038905	2950	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|gene gene|compound|END_ENTITY	Demethylation effects of elemene on the GSTP1 gene in HCC cell line QGY7703 .
19958867	0	elinogrel	75,84	P2Y12	117,122	elinogrel	P2Y12	MESH:C549473	64805	Chemical	Gene	therapy|nmod|START_ENTITY Safety|nmod|therapy Safety|appos|antagonist antagonist|compound|END_ENTITY	Safety and feasibility of adjunctive antiplatelet therapy with intravenous elinogrel , a direct-acting and reversible P2Y12 ADP-receptor antagonist , before primary percutaneous intervention in patients with ST-elevation_myocardial_infarction : the Early Rapid ReversAl of platelet_thromboSis with intravenous Elinogrel before PCI to optimize reperfusion in acute Myocardial_Infarction -LRB- ERASE MI -RRB- pilot trial .
21730013	0	elinogrel	109,118	P2Y12	148,153	elinogrel	P2Y12	MESH:C549473	70839(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	A clopidogrel-insensitive inducible pool of P2Y12 receptors contributes to thrombus formation : inhibition by elinogrel , a direct-acting , reversible P2Y12 antagonist .
21730013	0	elinogrel	109,118	P2Y12	44,49	elinogrel	P2Y12	MESH:C549473	70839(Tax:10090)	Chemical	Gene	inhibition|nmod|START_ENTITY contributes|dobj|inhibition contributes|nsubj|pool pool|nmod|receptors receptors|nummod|END_ENTITY	A clopidogrel-insensitive inducible pool of P2Y12 receptors contributes to thrombus formation : inhibition by elinogrel , a direct-acting , reversible P2Y12 antagonist .
8024593	0	ellagic_acid	8,20	CYP1A1	56,62	ellagic acid	CYP1A1	MESH:D004610	1543	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	Dietary ellagic_acid inhibits the enzymatic activity of CYP1A1 without altering hepatic concentrations of CYP1A1 or CYP1A1 mRNA .
21573219	0	ellagic_acid	60,72	MMP-2	87,92	ellagic acid	MMP-2	MESH:D004610	4313	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Zinc-chelation contributes to the anti-angiogenic effect of ellagic_acid on inhibiting MMP-2 activity , cell migration and tube formation .
17241782	0	elocalcitol	90,101	vitamin_D_receptor	54,72	elocalcitol	vitamin D receptor	MESH:C487049	7421	Chemical	Gene	BXL-628|dep|START_ENTITY BXL-628|compound|END_ENTITY	Inhibition of prostate growth and inflammation by the vitamin_D_receptor agonist BXL-628 -LRB- elocalcitol -RRB- .
22588001	0	elocalcitol	42,53	vitamin_D_receptor	14,32	elocalcitol	vitamin D receptor	MESH:C487049	22337(Tax:10090)	Chemical	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	The selective vitamin_D_receptor agonist , elocalcitol , reduces endometriosis development in a mouse model by inhibiting_peritoneal_inflammation .
1158431	0	eltroxine	10,19	monoamine_oxidase	39,56	eltroxine	monoamine oxidase	MESH:D013974	29253(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of eltroxine and neomercazol on monoamine_oxidase from rat tissues .
6200483	0	embryonin	19,28	alpha_2-macroglobulin	40,61	embryonin	alpha 2-macroglobulin	MESH:C036538	506828(Tax:9913)	Chemical	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of `` embryonin '' as bovine alpha_2-macroglobulin .
26742314	0	emodin	10,16	Aquaporin_5	20,31	emodin	Aquaporin 5	MESH:D004642	25241(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of emodin on Aquaporin_5 expression in rats with sepsis-induced acute_lung_injury .
24670452	0	emodin	12,18	IL-23	22,27	emodin	IL-23	MESH:D004642	83430(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of emodin on IL-23 / IL-17 inflammatory axis , Th17 cells and viral replication in mice with viral_myocarditis -RSB- .
15942676	0	emodin	22,28	NF-kappaB	32,41	emodin	NF-kappaB	MESH:D004642	4790	Chemical	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Regulatory effects of emodin on NF-kappaB activation and inflammatory cytokine expression in RAW 264.7 macrophages .
20575398	0	emodin	11,17	P-gp	21,25	emodin	P-gp	MESH:D004642	287115(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	-LSB- Effect of emodin on P-gp expression in intrahepatic cholestatic rats -RSB- .
17160480	0	emodin	21,27	TIMP-1	73,79	emodin	TIMP-1	MESH:D004642	116510(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|appos|END_ENTITY	Inhibitory effect of emodin on tissue_inhibitor_of_metalloproteinases-1 -LRB- TIMP-1 -RRB- expression in rat hepatic stellate cells .
18454691	0	emodin	14,20	VEGF	24,28	emodin	VEGF	MESH:D004642	7422	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|receptors receptors|compound|END_ENTITY	The effect of emodin on VEGF receptors in human colon_cancer cells .
8737457	0	emodin	10,16	c-myc	20,25	emodin	c-myc	MESH:D004642	24577(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of emodin on c-myc proto-oncongen expression in cultured rat mesangial cells .
16386736	0	emodin	29,35	myosin	67,73	emodin	myosin	MESH:D004642	79784	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Bi-directional regulation of emodin and quercetin on smooth muscle myosin of gizzard .
17160480	0	emodin	21,27	tissue_inhibitor_of_metalloproteinases-1	31,71	emodin	tissue inhibitor of metalloproteinases-1	MESH:D004642	116510(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|amod|END_ENTITY	Inhibitory effect of emodin on tissue_inhibitor_of_metalloproteinases-1 -LRB- TIMP-1 -RRB- expression in rat hepatic stellate cells .
19134459	0	emodin	27,33	transforming_growth_factor-beta1	37,69	emodin	transforming growth factor-beta1	MESH:D004642	59086(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	-LSB- Interventional effects of emodin on transforming_growth_factor-beta1 / integrin-linked_kinase signal way in interleukin-1beta-induced transdifferentiation of rat tubular epithelial-myofibroblasts -RSB- .
21985693	0	empagliflozin	25,38	SGLT-2	70,76	empagliflozin	SGLT-2	MESH:C570240	64522(Tax:10116)	Chemical	Gene	treatment|nmod|START_ENTITY treatment|appos|inhibitor inhibitor|compound|END_ENTITY	Long-term treatment with empagliflozin , a novel , potent and selective SGLT-2 inhibitor , improves glycaemic control and features of metabolic_syndrome in diabetic rats .
23054692	0	empagliflozin	20,33	SGLT-2	69,75	empagliflozin	SGLT-2	MESH:C570240	6524	Chemical	Gene	Pharmacokinetics|nmod|START_ENTITY Pharmacokinetics|appos|inhibitor inhibitor|appos|END_ENTITY	Pharmacokinetics of empagliflozin , a sodium_glucose cotransporter-2 -LRB- SGLT-2 -RRB- inhibitor , coadministered with sitagliptin in healthy volunteers .
23149871	0	empagliflozin	79,92	SGLT2	128,133	empagliflozin	SGLT2	MESH:C570240	6524	Chemical	Gene	doses|nmod|START_ENTITY tolerability|nmod|doses Safety|appos|tolerability Safety|appos|inhibitor inhibitor|compound|END_ENTITY	Safety , tolerability , pharmacokinetics and pharmacodynamics of single doses of empagliflozin , a sodium_glucose cotransporter 2 -LRB- SGLT2 -RRB- inhibitor , in healthy Japanese subjects .
23859488	0	empagliflozin	49,62	SGLT2	98,103	empagliflozin	SGLT2	MESH:C570240	6524	Chemical	Gene	pharmacodynamics|nmod|START_ENTITY Pharmacokinetics|appos|pharmacodynamics Pharmacokinetics|appos|inhibitor inhibitor|compound|END_ENTITY	Pharmacokinetics , pharmacodynamics and safety of empagliflozin , a sodium_glucose cotransporter 2 -LRB- SGLT2 -RRB- inhibitor , in subjects with renal_impairment .
23906374	0	empagliflozin	23,36	SGLT2	72,77	empagliflozin	SGLT2	MESH:C570240	6524	Chemical	Gene	Efficacy|nmod|START_ENTITY Efficacy|appos|inhibitor inhibitor|compound|END_ENTITY	Efficacy and safety of empagliflozin , a sodium_glucose cotransporter 2 -LRB- SGLT2 -RRB- inhibitor , as add-on to metformin in type 2 diabetes with mild hyperglycaemia .
24007456	0	empagliflozin	89,102	SGLT2	107,112	empagliflozin	SGLT2	MESH:C570240	6524	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Rationale , design and baseline characteristics of a 4-year -LRB- 208-week -RRB- phase III trial of empagliflozin , an SGLT2 inhibitor , versus glimepiride as add-on to metformin in patients with type_2_diabetes_mellitus with insufficient glycemic control .
24964723	0	empagliflozin	32,45	SGLT2	81,86	empagliflozin	SGLT2	MESH:C570240	6524	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|appos|END_ENTITY	Exposure-response modelling for empagliflozin , a sodium_glucose_cotransporter_2 -LRB- SGLT2 -RRB- inhibitor , in patients with type 2 diabetes .
25344694	0	empagliflozin	22,35	SGLT2	55,60	empagliflozin	SGLT2	MESH:C570240	246787(Tax:10090)	Chemical	Gene	control|nmod|START_ENTITY control|appos|inhibitor inhibitor|compound|END_ENTITY	Glycemic control with empagliflozin , a novel selective SGLT2 inhibitor , ameliorates cardiovascular_injury and cognitive_dysfunction in obese_and_type_2 diabetic mice .
25805666	4	empagliflozin	642,655	SGLT2	554,559	empagliflozin	SGLT2	MESH:C570240	6524	Chemical	Gene	countries|appos|START_ENTITY available|nmod|countries available|nsubj|inhibitors inhibitors|compound|END_ENTITY	Several SGLT2 inhibitors are already available in many countries -LRB- dapagliflozin , canagliflozin , empagliflozin -RRB- and in Japan -LRB- ipragliflozin , tofogliflozin -RRB- .
24964723	0	empagliflozin	32,45	sodium_glucose_cotransporter_2	49,79	empagliflozin	sodium glucose cotransporter 2	MESH:C570240	6524	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Exposure-response modelling for empagliflozin , a sodium_glucose_cotransporter_2 -LRB- SGLT2 -RRB- inhibitor , in patients with type 2 diabetes .
10350000	0	enalapril	55,64	ACE	128,131	enalapril	ACE	MESH:D004656	100009274(Tax:9986)	Chemical	Gene	transport|nmod|START_ENTITY inhibition|nmod|transport inhibition|dep|interaction interaction|nmod|inhibitors inhibitors|compound|END_ENTITY	Competitive inhibition of glycylsarcosine transport by enalapril in rabbit renal brush border membrane vesicles : interaction of ACE inhibitors with high-affinity H + / peptide symporter .
10938492	0	enalapril	118,127	ACE	60,63	enalapril	ACE	MESH:D004656	1636	Chemical	Gene	comparison|nmod|START_ENTITY hypotension|dep|comparison hypotension|nmod|inhibitors inhibitors|appos|END_ENTITY	First-dose hypotension after angiotensin-converting_enzyme -LRB- ACE -RRB- inhibitors in chronic_heart_failure : a comparison of enalapril and perindopril .
11205963	0	enalapril	136,145	ACE	20,23	enalapril	ACE	MESH:D004656	1636	Chemical	Gene	dose|nmod|START_ENTITY administration|nmod|dose subjects|nmod|administration subjects|nsubj|Correlation Correlation|nmod|activity activity|compound|END_ENTITY	Correlation between ACE activity and mean blood pressure in Iranian normotensive subjects after oral administration of a single dose of enalapril .
11975696	0	enalapril	53,62	ACE	22,25	enalapril	ACE	MESH:D004656	1636	Chemical	Gene	dose|nmod|START_ENTITY inhibition|nmod|dose inhibition|nsubj|Relationship Relationship|nmod|END_ENTITY	Relationship of serum ACE inhibition to oral dose of enalapril in normotensive volunteers .
12240792	0	enalapril	48,57	ACE	0,3	enalapril	ACE	MESH:D004656	1636	Chemical	Gene	switching|nmod|START_ENTITY inhibitors|parataxis|switching inhibitors|nsubj|END_ENTITY	ACE inhibitors in heart_failure -- switching from enalapril to perindopril .
15036801	0	enalapril	52,61	ACE	37,40	enalapril	ACE	MESH:D004656	1636	Chemical	Gene	activity|dep|START_ENTITY activity|nmod|inhibitor inhibitor|compound|END_ENTITY	Sympathetic activity and response to ACE inhibitor -LRB- enalapril -RRB- in normotensive obese_and_non-obese subjects .
1586932	0	enalapril	20,29	ACE	5,8	enalapril	ACE	MESH:D004656	1636	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	-LSB- The ACE inhibitor , enalapril , in portal_hypertension .
1773691	1	enalapril	78,87	ACE	64,67	enalapril	ACE	MESH:D004656	1636	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|END_ENTITY	Antagonist verapamil and/or ACE inhibitor enalapril in NIDDM patients .
17926468	0	enalapril	48,57	ACE	34,37	enalapril	ACE	MESH:D004656	1636	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|Clinical Clinical|nmod|END_ENTITY	-LSB- Clinical and vascular effects of ACE inhibitor enalapril in combination with thiaside-like diuretic indapamide in hypertensive outpatients .
19854435	0	enalapril	19,28	ACE	4,7	enalapril	ACE	MESH:D004656	11421(Tax:10090)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	The ACE inhibitors enalapril and captopril modulate cytokine responses in Balb/c and C57Bl/6 normal mice and increase CD4 -LRB- + -RRB- CD103 -LRB- + -RRB- CD25 -LRB- negative -RRB- splenic_T cell numbers .
2102138	0	enalapril	166,175	ACE	27,30	enalapril	ACE	MESH:D004656	1636	Chemical	Gene	-RSB-|compound|START_ENTITY comparison|nmod|-RSB- Effects|dep|comparison Effects|nmod|treatment treatment|nmod|END_ENTITY	-LSB- Effects of treatment with ACE and serotonin inhibitors on arterial blood pressure at rest and cycloergometric exercise and on systolic time intervals : comparison of enalapril and ketanserin -RSB- .
2831117	0	enalapril	85,94	ACE	14,17	enalapril	ACE	MESH:D004656	1636	Chemical	Gene	arterial_hypertension|nmod|START_ENTITY treatment|nmod|arterial_hypertension Rationale|dep|treatment Rationale|nmod|inhibition inhibition|compound|END_ENTITY	Rationale for ACE inhibition in the elderly : treatment of arterial_hypertension with enalapril .
7473177	0	enalapril	117,126	ACE	48,51	enalapril	ACE	MESH:D004656	24310(Tax:10116)	Chemical	Gene	characterization|nmod|START_ENTITY Moexipril|dep|characterization Moexipril|appos|inhibitor inhibitor|appos|END_ENTITY	Moexipril , a new angiotensin-converting enzyme -LRB- ACE -RRB- inhibitor : pharmacological characterization and comparison with enalapril .
7742150	0	enalapril	89,98	ACE	53,56	enalapril	ACE	MESH:D004656	1636	Chemical	Gene	dose|nmod|START_ENTITY END_ENTITY|nmod|dose	Relation between changes in blood pressure and serum ACE activity after a single dose of enalapril and ACE genotype in healthy subjects .
8231461	0	enalapril	68,77	ACE	22,25	enalapril	ACE	MESH:D004656	1636	Chemical	Gene	administration|nmod|START_ENTITY vitro|nmod|administration activity|acl|vitro activity|compound|END_ENTITY	Measurements of serum ACE activity in vitro after administration of enalapril in man can not reflect inhibition of the enzyme in vivo .
9049577	0	enalapril	10,19	ACE	54,57	enalapril	ACE	MESH:D004656	1636	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of enalapril and quinapril on forearm vascular ACE in man .
11441198	0	enalapril	46,55	Angiotensin-converting_enzyme	0,29	enalapril	Angiotensin-converting enzyme	MESH:D004656	1636	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Angiotensin-converting_enzyme inhibition with enalapril slows progressive intima-media thickening of the common carotid artery in patients with non-insulin-dependent_diabetes_mellitus .
3013653	0	enalapril	50,59	Angiotensin-converting_enzyme	0,29	enalapril	Angiotensin-converting enzyme	MESH:D004656	24310(Tax:10116)	Chemical	Gene	responses|nmod|START_ENTITY responses|amod|END_ENTITY	Angiotensin-converting_enzyme responses following enalapril in the sodium deficient rat .
9049213	0	enalapril	44,53	Angiotensin-converting_enzyme	0,29	enalapril	Angiotensin-converting enzyme	MESH:D004656	24310(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Angiotensin-converting_enzyme inhibition by enalapril : a novel approach to reduce ischemia/reperfusion damage after experimental liver transplantation .
9661139	0	enalapril	114,123	Angiotensin-converting_enzyme	0,29	enalapril	Angiotensin-converting enzyme	MESH:D004656	1636	Chemical	Gene	effect|nmod|START_ENTITY determines|dobj|effect determines|nsubj|polymorphism polymorphism|amod|END_ENTITY	Angiotensin-converting_enzyme gene polymorphism determines the antiproteinuric and systemic hemodynamic effect of enalapril in patients with proteinuric_renal_disease .
8346593	0	enalapril	43,52	Angiotensin_I_converting_enzyme	1,32	enalapril	Angiotensin I converting enzyme	MESH:D004656	1636	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|END_ENTITY	-LSB- Angiotensin_I_converting_enzyme inhibitor enalapril in treatment of progressive chronic nephropathy .
2853753	0	enalapril	60,69	Angiotensin_converting_enzyme	0,29	enalapril	Angiotensin converting enzyme	MESH:D004656	1636	Chemical	Gene	dose|nmod|START_ENTITY inhibition|nmod|dose inhibition|nsubj|END_ENTITY	Angiotensin_converting_enzyme inhibition with a low dose of enalapril in normotensive diabetics with persistent proteinuria .
6097377	0	enalapril	55,64	Angiotensin_converting_enzyme	0,29	enalapril	Angiotensin converting enzyme	MESH:D004656	1636	Chemical	Gene	therapy|amod|START_ENTITY END_ENTITY|nmod|therapy	Angiotensin_converting_enzyme during acute and chronic enalapril therapy in essential hypertension .
17901573	0	enalapril	13,22	IL-6	129,133	enalapril	IL-6	MESH:D004656	24498(Tax:10116)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|acl|induced induced|dobj|concentrations concentrations|amod|END_ENTITY	Influence of enalapril , quinapril and losartan on lipopolysaccharide -LRB- LPS -RRB- - induced serum concentrations of TNF-alpha , IL-1_beta , IL-6 in spontaneously hypertensive rats -LRB- SHR -RRB- .
21265103	0	enalapril	12,21	IL-6	35,39	enalapril	IL-6	MESH:D004656	24498(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|amod|END_ENTITY	-LSB- Effects of enalapril on IL-1beta , IL-6 expression in rat lung exposure to acrolein -RSB- .
19197123	0	enalapril	11,20	TGF-beta1	42,51	enalapril	TGF-beta1	MESH:D004656	59086(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of enalapril on the expression of TGF-beta1 , p-Smad2 / 3 and Smad7 in renal_interstitial_fibrosis in rats -RSB- .
19922882	0	enalapril	109,118	adiponectin	144,155	enalapril	adiponectin	MESH:D004656	9370	Chemical	Gene	comparison|nmod|START_ENTITY comparison|nmod|concentrations concentrations|compound|END_ENTITY	Prospective , randomized , single-blind comparison of effects of 6 months of treatment with telmisartan versus enalapril on high-molecular-weight adiponectin concentrations in patients with coronary_artery_disease .
10089936	0	enalapril	65,74	angiotensin-converting_enzyme	25,54	enalapril	angiotensin-converting enzyme	MESH:D004656	1636	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Long-term effects of the angiotensin-converting_enzyme inhibitor enalapril on chronic heart_failure .
10474773	0	enalapril	117,126	angiotensin-converting_enzyme	76,105	enalapril	angiotensin-converting enzyme	MESH:D004656	24310(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Hyperlipidaemia and the progression of nephropathy in OLETF rats : effect of angiotensin-converting_enzyme inhibitor , enalapril .
10688628	0	enalapril	115,124	angiotensin-converting_enzyme	65,94	enalapril	angiotensin-converting enzyme	MESH:D004656	610668(Tax:9615)	Chemical	Gene	case|nmod|START_ENTITY insights|dep|case insights|nmod|effect effect|nmod|kidney_insufficiency kidney_insufficiency|nmod|disposition disposition|nmod|inhibitors inhibitors|amod|END_ENTITY	New insights on effect of kidney_insufficiency on disposition of angiotensin-converting_enzyme inhibitors : case of enalapril and benazepril in dogs .
10938492	0	enalapril	118,127	angiotensin-converting_enzyme	29,58	enalapril	angiotensin-converting enzyme	MESH:D004656	1636	Chemical	Gene	comparison|nmod|START_ENTITY hypotension|dep|comparison hypotension|nmod|inhibitors inhibitors|amod|END_ENTITY	First-dose hypotension after angiotensin-converting_enzyme -LRB- ACE -RRB- inhibitors in chronic_heart_failure : a comparison of enalapril and perindopril .
11588528	0	enalapril	70,79	angiotensin-converting_enzyme	24,53	enalapril	angiotensin-converting enzyme	MESH:D004656	1636	Chemical	Gene	administration|compound|START_ENTITY activity|nmod|administration activity|amod|END_ENTITY	T-lymphocyte and plasma angiotensin-converting_enzyme activity during enalapril and losartan administration in humans .
12558131	0	enalapril	55,64	angiotensin-converting_enzyme	15,44	enalapril	angiotensin-converting enzyme	MESH:D004656	24310(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Effects of the angiotensin-converting_enzyme inhibitor enalapril on sympathetic neuronal function and beta-adrenergic desensitization in heart_failure after myocardial_infarction in rats .
15523323	0	enalapril	110,119	angiotensin-converting_enzyme	10,39	enalapril	angiotensin-converting enzyme	MESH:D004656	1636	Chemical	Gene	Impact|parataxis|START_ENTITY Impact|nmod|polymorphism polymorphism|amod|END_ENTITY	Impact of angiotensin-converting_enzyme gene polymorphism on neurohormonal responses to high - versus low-dose enalapril in advanced heart_failure .
15848608	0	enalapril	125,134	angiotensin-converting_enzyme	13,42	enalapril	angiotensin-converting enzyme	MESH:D004656	1636	Chemical	Gene	Influence|acl|START_ENTITY Influence|nmod|gene gene|amod|END_ENTITY	Influence of angiotensin-converting_enzyme polymorphism gene , IGF-1 , and other factors in the response rate of hematocrit to enalapril treatment in patients with posttransplant_erythrocytosis .
1661665	0	enalapril	14,23	angiotensin-converting_enzyme	76,105	enalapril	angiotensin-converting enzyme	MESH:D004656	1636	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nsubj|effect	The effect of enalapril on nephrotic_proteinuria and determination of serum angiotensin-converting_enzyme before and after treatment .
1725028	0	enalapril	84,93	angiotensin-converting_enzyme	29,58	enalapril	angiotensin-converting enzyme	MESH:D004656	1636	Chemical	Gene	START_ENTITY|nsubj|Efficacy Efficacy|nmod|ramipril ramipril|amod|END_ENTITY	Efficacy and safety of a new angiotensin-converting_enzyme inhibitor , ramipril , vs. enalapril in essential hypertension : a multicenter trial .
2536602	0	enalapril	61,70	angiotensin-converting_enzyme	21,50	enalapril	angiotensin-converting enzyme	MESH:D004656	1636	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|inhibitor inhibitor|amod|END_ENTITY	Short-term effect of angiotensin-converting_enzyme inhibitor enalapril in incipient_diabetic_nephropathy .
2556456	0	enalapril	75,84	angiotensin-converting_enzyme	29,58	enalapril	angiotensin-converting enzyme	MESH:D004656	1636	Chemical	Gene	homeostasis|nmod|START_ENTITY homeostasis|nmod|inhibition inhibition|amod|END_ENTITY	Potassium homeostasis during angiotensin-converting_enzyme inhibition with enalapril .
6097696	0	enalapril	49,58	angiotensin-converting_enzyme	18,47	enalapril	angiotensin-converting enzyme	MESH:D004656	24310(Tax:10116)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Two inhibitors of angiotensin-converting_enzyme , enalapril and captopril , increase salt appetite of rats .
8640982	0	enalapril	66,75	angiotensin-converting_enzyme	10,39	enalapril	angiotensin-converting enzyme	MESH:D004656	1636	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Long-term angiotensin-converting_enzyme inhibition with high-dose enalapril retards nitrate tolerance in large epicardial arteries and prevents rebound coronary vasoconstriction in vivo .
9352252	0	enalapril	55,64	angiotensin-converting_enzyme	15,44	enalapril	angiotensin-converting enzyme	MESH:D004656	1636	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Effects of the angiotensin-converting_enzyme inhibitor enalapril on blood haematopoietic progenitors and acetyl-N-Ser-Asp-Lys-Pro concentrations .
10234113	0	enalapril	153,162	angiotensin_II	17,31	enalapril	angiotensin II	MESH:D004656	183	Chemical	Gene	START_ENTITY|nsubj|Valsartan Valsartan|appos|antagonist antagonist|compound|END_ENTITY	Valsartan , a new angiotensin_II antagonist ; blood pressure reduction in essential hypertension compared with an angiotensin converting enzyme inhibitor , enalapril .
21921804	0	enalapril	9,18	angiotensin_II	27,41	enalapril	angiotensin II	MESH:D004656	24179(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|iobj|END_ENTITY	Low-dose enalapril reduces angiotensin_II and attenuates diabetic-induced cardiac_and_autonomic_dysfunctions .
2407244	0	enalapril	18,27	angiotensin_II	114,128	enalapril	angiotensin II	MESH:D004656	24179(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY Effect|nmod|treatment Effect|nmod|END_ENTITY	Effect of chronic enalapril treatment on enzymes responsible for the catabolism of angiotensin_I and formation of angiotensin_II .
6143602	0	enalapril	10,19	angiotensin_I_converting_enzyme	47,78	enalapril	angiotensin I converting enzyme	MESH:D004656	24310(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Effect of enalapril -LRB- MK-421 -RRB- , an orally active angiotensin_I_converting_enzyme inhibitor , on blood pressure , active and inactive plasma renin , urinary prostaglandin_E2 , and kallikrein excretion in conscious rats .
10422218	0	enalapril	47,56	angiotensin_converting_enzyme	16,45	enalapril	angiotensin converting enzyme	MESH:D004656	613133(Tax:9823)	Chemical	Gene	inhibitor|dep|START_ENTITY inhibitor|nmod|END_ENTITY	An inhibitor of angiotensin_converting_enzyme -LRB- enalapril -RRB- augments endotoxin-induced hypotension in the pig .
12014588	0	enalapril	62,71	angiotensin_converting_enzyme	29,58	enalapril	angiotensin converting enzyme	MESH:D004656	101094061	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Dose-dependent inhibition of angiotensin_converting_enzyme by enalapril in cats .
12661873	0	enalapril	78,87	angiotensin_converting_enzyme	43,72	enalapril	angiotensin converting enzyme	MESH:D004656	610668(Tax:9615)	Chemical	Gene	Evaluation|nmod|START_ENTITY Evaluation|nmod|END_ENTITY	Evaluation of the effects of inhibition of angiotensin_converting_enzyme with enalapril in dogs with induced chronic renal_insufficiency .
1638712	0	enalapril	55,64	angiotensin_converting_enzyme	15,44	enalapril	angiotensin converting enzyme	MESH:D004656	1636	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Effects of the angiotensin_converting_enzyme inhibitor enalapril on the long-term progression of left_ventricular_dysfunction in patients with heart_failure .
2851039	0	enalapril	55,64	angiotensin_converting_enzyme	15,44	enalapril	angiotensin converting enzyme	MESH:D004656	1636	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Effects of the angiotensin_converting_enzyme inhibitor enalapril compared with diuretic therapy in elderly hypertensive patients .
2995119	0	enalapril	26,35	angiotensin_converting_enzyme	49,78	enalapril	angiotensin converting enzyme	MESH:D004656	1636	Chemical	Gene	derivatives|nmod|START_ENTITY derivatives|nmod|inhibitors inhibitors|compound|END_ENTITY	Imidazolyl derivatives of enalapril as potential angiotensin_converting_enzyme inhibitors .
6100614	0	enalapril	44,53	angiotensin_converting_enzyme	4,33	enalapril	angiotensin converting enzyme	MESH:D004656	1636	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|END_ENTITY	The angiotensin_converting_enzyme inhibitor enalapril and its effects on renal function .
8139090	0	enalapril	119,128	angiotensin_converting_enzyme	73,102	enalapril	angiotensin converting enzyme	MESH:D004656	1636	Chemical	Gene	function|nmod|START_ENTITY function|nmod|inhibition inhibition|amod|END_ENTITY	Ventricular unloading and improvement in left ventricular function after angiotensin_converting_enzyme inhibition with enalapril in patients with chronic congestive_heart_failure .
8222122	0	enalapril	55,64	angiotensin_converting_enzyme	15,44	enalapril	angiotensin converting enzyme	MESH:D004656	1636	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Effects of the angiotensin_converting_enzyme inhibitor enalapril on the long-term progression of left_ventricular_dilatation in patients with asymptomatic systolic_dysfunction .
8984133	0	enalapril	102,111	angiotensin_converting_enzyme	62,91	enalapril	angiotensin converting enzyme	MESH:D004656	1636	Chemical	Gene	START_ENTITY|nsubj|Comparison Comparison|nmod|losartan losartan|nmod|inhibitor inhibitor|amod|END_ENTITY	Comparison of the angiotensin_II antagonist losartan with the angiotensin_converting_enzyme inhibitor enalapril in patients with essential hypertension .
2536642	0	enalapril	20,29	atrial_natriuretic_factor	74,99	enalapril	atrial natriuretic factor	MESH:D004656	4878	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Opposite effects of enalapril and nitrendipine on natriuretic response to atrial_natriuretic_factor .
3028457	0	enalapril	10,19	bradykinin	44,54	enalapril	bradykinin	MESH:D004656	3827	Chemical	Gene	Effect|nmod|START_ENTITY Effect|acl|END_ENTITY	Effect of enalapril on the skin response to bradykinin in man .
6313833	0	enalapril	121,130	bradykinin	15,25	enalapril	bradykinin	MESH:D004656	3827	Chemical	Gene	Immunoreactive|nmod|START_ENTITY Immunoreactive|dobj|-RSB- -RSB-|amod|END_ENTITY	Immunoreactive bradykinin and -LSB- des-Arg9 -RSB- - bradykinin in low-renin essential hypertension -- before and after treatment with enalapril -LRB- MK_421 -RRB- .
6313833	0	enalapril	121,130	bradykinin	41,51	enalapril	bradykinin	MESH:D004656	3827	Chemical	Gene	Immunoreactive|nmod|START_ENTITY Immunoreactive|dobj|-RSB- -RSB-|dep|END_ENTITY	Immunoreactive bradykinin and -LSB- des-Arg9 -RSB- - bradykinin in low-renin essential hypertension -- before and after treatment with enalapril -LRB- MK_421 -RRB- .
8195682	0	enalapril	11,20	endothelin-1	24,36	enalapril	endothelin-1	MESH:D004656	24323(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|amod|END_ENTITY	Effects of enalapril on endothelin-1 and growth_factor gene expression in diabetic rat glomeruli .
8586009	0	enalapril	11,20	epidermal_growth_factor	58,81	enalapril	epidermal growth factor	MESH:D004656	1950	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|excretion excretion|nmod|END_ENTITY	Effects of enalapril and nitrendipine on the excretion of epidermal_growth_factor and albumin in hypertensive NIDDM patients .
2247767	0	enalapril	10,19	erythropoietin	45,59	enalapril	erythropoietin	MESH:D004656	2056	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of enalapril on haemoglobin and serum erythropoietin in patients with chronic nephropathy .
2553845	0	enalapril	98,107	erythropoietin	11,25	enalapril	erythropoietin	MESH:D004656	2056	Chemical	Gene	normalized|nmod|START_ENTITY normalized|nsubjpass|levels levels|compound|END_ENTITY	High serum erythropoietin levels are normalized during treatment of congestive_heart_failure with enalapril .
9623555	0	enalapril	10,19	erythropoietin	44,58	enalapril	erythropoietin	MESH:D004656	2056	Chemical	Gene	impairs|nsubj|START_ENTITY impairs|nmod|treatment treatment|compound|END_ENTITY	High dose enalapril impairs the response to erythropoietin treatment in haemodialysis patients .
9829495	0	enalapril	10,19	erythropoietin	35,49	enalapril	erythropoietin	MESH:D004656	2056	Chemical	Gene	START_ENTITY|nmod|response response|compound|END_ENTITY	Effect of enalapril on exaggerated erythropoietin response to phlebotomy in erythrocytosic_renal_transplant_patients .
10859154	0	enalapril	10,19	organic_anion_transporting_polypeptide_1	38,78	enalapril	organic anion transporting polypeptide 1	MESH:D004656	50572(Tax:10116)	Chemical	Gene	Uptake|nmod|START_ENTITY Uptake|nmod|END_ENTITY	Uptake of enalapril and expression of organic_anion_transporting_polypeptide_1 in zonal , isolated rat hepatocytes .
6307331	0	enalapril	14,23	prolactin	33,42	enalapril	prolactin	MESH:D004656	5617	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of enalapril on serum prolactin .
1707646	0	enalapril	15,24	substance_P	64,75	enalapril	substance P	MESH:D004656	6863	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|response response|nmod|END_ENTITY	The effects of enalapril and sulindac on the dermal response to substance_P and neurokinin_A .
24216112	0	enalapril_maleate	41,58	Angiotensin-converting_enzyme	0,29	enalapril maleate	Angiotensin-converting enzyme	MESH:D004656	11421(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Angiotensin-converting_enzyme inhibitor -LRB- enalapril_maleate -RRB- accelerates recovery of mouse skin from UVB-induced wrinkles .
3012006	0	enalapril_maleate	73,90	angiotensin-converting_enzyme	32,61	enalapril maleate	angiotensin-converting enzyme	MESH:D004656	1636	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	The therapeutic effect of a new angiotensin-converting_enzyme inhibitor , enalapril_maleate , in idiopathic_hyperaldosteronism .
25784288	0	enalapril_maleate	10,27	ghrelin	31,38	enalapril maleate	ghrelin	MESH:D004656	59301(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|compound|END_ENTITY	Effect of enalapril_maleate on ghrelin levels in metabolic_syndrome in rats .
2991035	0	enalapril_maleate	73,90	renin	118,123	enalapril maleate	renin	MESH:D004656	5972	Chemical	Gene	plasma|nsubj|START_ENTITY plasma|dobj|END_ENTITY	-LSB- The acute effects of the new angiotensin_I-converting_enzyme inhibitor , enalapril_maleate , on blood pressure , plasma renin , aldosterone and kinins in hypertensive patients -RSB- .
2994914	0	enalapril_maleate	11,28	renin	57,62	enalapril maleate	renin	MESH:D004656	5972	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of enalapril_maleate on plasma level of inactive renin in renovascular_hypertension .
9331154	0	enalaprilate	18,30	ACE	0,3	enalaprilate	ACE	CHEBI:4786	24310(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	ACE inhibition by enalaprilate stimulates duodenal mucosal alkaline secretion via a bradykinin pathway in the rat .
11270983	0	endoperoxides	42,55	Endothelin-1	0,12	endoperoxides	Endothelin-1	null	1906	Chemical	Gene	releases|dobj|START_ENTITY releases|nsubj|END_ENTITY	Endothelin-1 releases endothelium-derived endoperoxides and thromboxane_A2 in porcine coronary arteries with regenerated endothelium .
4093546	0	endosulfan	67,77	cytochrome_P-450	13,29	endosulfan	cytochrome P-450	MESH:D004726	25251(Tax:10116)	Chemical	Gene	synthesis|nmod|START_ENTITY synthesis|amod|END_ENTITY	Induction of cytochrome_P-450 and phosphatidylcholine synthesis by endosulfan in liver of rats : effect of quality of dietary proteins .
9185323	0	endosulfan	10,20	malate_dehydrogenase	60,80	endosulfan	malate dehydrogenase	MESH:D004726	4200	Chemical	Gene	Impact|nmod|START_ENTITY END_ENTITY|nsubj|Impact	Impact of endosulfan on cytoplasmic and mitochondrial liver malate_dehydrogenase from the freshwater catfish -LRB- Clarias batrachus -RRB- .
8067446	0	endothelin	51,61	atrial_natriuretic_factor	14,39	endothelin	atrial natriuretic factor	MESH:D016232	4878	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of atrial_natriuretic_factor release by endothelin in ovine fetuses .
10972486	0	enediol	70,77	glyoxalase_I	100,112	enediol	glyoxalase I	null	109801(Tax:10090)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|nmod|END_ENTITY	Pharmacokinetics and antitumor properties in tumor-bearing mice of an enediol analogue inhibitor of glyoxalase_I .
8198912	0	enflurane	71,80	Choline_acetyltransferase	0,25	enflurane	Choline acetyltransferase	MESH:D004737	290567(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|activity activity|amod|END_ENTITY	Choline_acetyltransferase activity of rat synaptosomes is sensitive to enflurane , but not halothane or isoflurane .
8689955	0	enflurane	30,39	cytochrome_P450_2E1	55,74	enflurane	cytochrome P450 2E1	MESH:D004737	1571	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|nmod|END_ENTITY	Stereoselective metabolism of enflurane by human liver cytochrome_P450_2E1 .
12006517	0	eniluracil	39,49	dihydropyrimidine_dehydrogenase	108,139	eniluracil	dihydropyrimidine dehydrogenase	MESH:C073482	1806	Chemical	Gene	schedules|nmod|START_ENTITY Impact|nmod|schedules given|nsubj|Impact given|nmod|duration duration|nmod|inhibition inhibition|amod|END_ENTITY	Impact of two weekly schedules of oral eniluracil given with fluorouracil and leucovorin on the duration of dihydropyrimidine_dehydrogenase inhibition .
12448660	0	eniluracil	137,147	dihydropyrimidine_dehydrogenase	48,79	eniluracil	dihydropyrimidine dehydrogenase	MESH:C073482	1806	Chemical	Gene	trial|nmod|START_ENTITY modulation|dep|trial modulation|nmod|inhibition inhibition|amod|5-fluorouacil 5-fluorouacil|nmod|END_ENTITY	Biochemical modulation of 5-fluorouacil through dihydropyrimidine_dehydrogenase inhibition : a Southwest Oncology Group phase II trial of eniluracil and 5-fluorouracil in advanced resistant colorectal_cancer .
11210393	0	eniporide	64,73	NHE	50,53	eniporide	NHE	MESH:C118397	285335	Chemical	Gene	START_ENTITY|nsubj|evaluation evaluation|nmod|inhibitor inhibitor|compound|END_ENTITY	Pharmacokinetic/pharmacodynamic evaluation of the NHE inhibitor eniporide .
2460071	0	enkephalin	64,74	CGRP	58,62	enkephalin	CGRP	MESH:D004745	796	Chemical	Gene	VIP|appos|START_ENTITY VIP|appos|END_ENTITY	Immunohistochemical studies of the neurochemical markers , CGRP , enkephalin , galanin , gamma-MSH , NPY , PHI , proctolin , PTH , somatostatin , SP , VIP , tyrosine hydroxylase and neurofilament in nerves and cells of the human attached_gingiva .
2460071	0	enkephalin	64,74	NPY	96,99	enkephalin	NPY	MESH:D004745	4852	Chemical	Gene	VIP|appos|START_ENTITY VIP|appos|END_ENTITY	Immunohistochemical studies of the neurochemical markers , CGRP , enkephalin , galanin , gamma-MSH , NPY , PHI , proctolin , PTH , somatostatin , SP , VIP , tyrosine hydroxylase and neurofilament in nerves and cells of the human attached_gingiva .
2460071	0	enkephalin	64,74	PTH	117,120	enkephalin	PTH	MESH:D004745	5741	Chemical	Gene	VIP|appos|START_ENTITY VIP|appos|END_ENTITY	Immunohistochemical studies of the neurochemical markers , CGRP , enkephalin , galanin , gamma-MSH , NPY , PHI , proctolin , PTH , somatostatin , SP , VIP , tyrosine hydroxylase and neurofilament in nerves and cells of the human attached_gingiva .
2460071	0	enkephalin	64,74	gamma-MSH	85,94	enkephalin	gamma-MSH	MESH:D004745	5443	Chemical	Gene	VIP|appos|START_ENTITY VIP|appos|END_ENTITY	Immunohistochemical studies of the neurochemical markers , CGRP , enkephalin , galanin , gamma-MSH , NPY , PHI , proctolin , PTH , somatostatin , SP , VIP , tyrosine hydroxylase and neurofilament in nerves and cells of the human attached_gingiva .
6409709	0	enkephalin	10,20	gastrin	60,67	enkephalin	gastrin	MESH:D004745	2520	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of enkephalin and naloxone on gastric_acid and serum gastrin and pancreatic_polypeptide concentrations in humans .
3713995	0	enkephalin	28,38	oxytocin	10,18	enkephalin	oxytocin	MESH:D004745	18429(Tax:10090)	Chemical	Gene	tolerance|compound|START_ENTITY Effect|nmod|tolerance Effect|nmod|END_ENTITY	Effect of oxytocin on acute enkephalin tolerance in mice .
1694106	0	enkephalin	32,42	substance_P	102,113	enkephalin	substance P	MESH:D004745	6863	Chemical	Gene	distribution|amod|START_ENTITY neuropeptide|nsubj|distribution neuropeptide|dobj|VIP VIP|dep|END_ENTITY	Distinct distribution of CGRP - , enkephalin - , galanin - , neuromedin_U - , neuropeptide Y - , somatostatin - , substance_P - , VIP - and serotonin-containing neurons in the two submucosal_ganglionic_neural_networks of the porcine small intestine .
356933	0	enkephalin	6,16	substance_P	19,30	enkephalin	substance P	MESH:D004745	21333(Tax:10090)	Chemical	Gene	-|appos|START_ENTITY -|appos|END_ENTITY	VIP - , enkephalin - , substance_P - and somatostatin-like immunoreactivity in neurons intrinsic to the intestine : immunohistochemical evidence from organotypic tissue cultures .
6176901	0	enkephalin	66,76	substance_P	52,63	enkephalin	substance P	MESH:D004745	6863	Chemical	Gene	immunoreactive|nsubj|START_ENTITY immunoreactive|advcl|END_ENTITY	Distribution of vasoactive intestinal polypeptide - , substance_P - , enkephalin and neurotensin-like immunoreactive nerves in the chicken gut during development .
638316	0	enkephalin	26,36	vasopressin	11,22	enkephalin	vasopressin	MESH:D004745	551	Chemical	Gene	Release|nmod|START_ENTITY Release|nmod|END_ENTITY	Release of vasopressin by enkephalin .
22035050	0	enoxaparin	128,138	Factor_Xa	27,36	enoxaparin	Factor Xa	MESH:D017984	2159	Chemical	Gene	comparing|nmod|START_ENTITY study|acl|comparing effect|dep|study effect|nmod|inhibitor inhibitor|compound|END_ENTITY	The effect of a new direct Factor_Xa inhibitor on human osteoblasts : an in-vitro study comparing the effect of rivaroxaban with enoxaparin .
15238596	0	enoxaparin	65,75	antithrombin	106,118	enoxaparin	antithrombin	MESH:D017984	462	Chemical	Gene	START_ENTITY|dobj|heparin heparin|nmod|therapy therapy|compound|END_ENTITY	Efficacy and bleeding complications among patients randomized to enoxaparin or unfractionated heparin for antithrombin therapy in non-ST-Segment elevation acute_coronary_syndromes : a systematic overview .
17010793	0	enoxaparin	109,119	antithrombin	54,66	enoxaparin	antithrombin	MESH:D017984	462	Chemical	Gene	analysis|dep|START_ENTITY analysis|nmod|impact impact|nmod|therapy therapy|compound|END_ENTITY	A subgroup analysis of the impact of prerandomization antithrombin therapy on outcomes in the SYNERGY trial : enoxaparin versus unfractionated heparin in non-ST-segment elevation acute_coronary_syndromes .
17621651	0	enoxaparin	92,102	antithrombin	66,78	enoxaparin	antithrombin	MESH:D017984	462	Chemical	Gene	therapy|nmod|START_ENTITY therapy|compound|END_ENTITY	Macroscopic thrombus formation on angioplasty equipment following antithrombin therapy with enoxaparin .
20339323	0	enoxaparin	23,33	factor_Xa	76,85	enoxaparin	factor Xa	MESH:D017984	2159	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of nadroparin , enoxaparin , and unfractionated heparin on endogenous factor_Xa and IIa formation and on thrombelastometry profiles .
21150227	0	enoxaparin	23,33	factor_Xa	89,98	enoxaparin	factor Xa	MESH:D017984	2159	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|formation formation|nmod|END_ENTITY	Effects of nadroparin , enoxaparin , and unfractionated heparin on endogenous formation of factor_Xa and IIa and on thrombelastometry profiles in cord versus adult blood .
26498222	0	enoxaparin	39,49	factor_Xa	12,21	enoxaparin	factor Xa	MESH:D017984	2159	Chemical	Gene	inhibitor|nmod|START_ENTITY inhibitor|compound|END_ENTITY	Oral direct factor_Xa inhibitor versus enoxaparin for thromboprophylaxis after hip or knee arthroplasty : Systemic review , traditional meta-analysis , dose-response meta-analysis and network meta-analysis .
15081569	0	enoxaparin	119,129	thrombin	155,163	enoxaparin	thrombin	MESH:D017984	2147	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|generation generation|compound|END_ENTITY	The inhibitory effect of melagatran , the active form of the oral direct thrombin inhibitor ximelagatran , compared with enoxaparin and r-hirudin on ex vivo thrombin generation in human plasma .
15081569	0	enoxaparin	119,129	thrombin	72,80	enoxaparin	thrombin	MESH:D017984	2147	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|form form|nmod|ximelagatran ximelagatran|compound|END_ENTITY	The inhibitory effect of melagatran , the active form of the oral direct thrombin inhibitor ximelagatran , compared with enoxaparin and r-hirudin on ex vivo thrombin generation in human plasma .
15634273	0	enoxaparin	74,84	thrombin	18,26	enoxaparin	thrombin	MESH:D017984	2147	Chemical	Gene	inhibitor|nmod|START_ENTITY inhibitor|compound|END_ENTITY	A new oral direct thrombin inhibitor , dabigatran_etexilate , compared with enoxaparin for prevention of thromboembolic_events following total hip or knee replacement : the BISTRO II randomized trial .
21584633	0	enoxaparin	69,79	thrombin	8,16	enoxaparin	thrombin	MESH:D017984	2147	Chemical	Gene	generation|nmod|START_ENTITY generation|compound|END_ENTITY	Reduced thrombin generation and soluble P-selectin after intravenous enoxaparin during PCI .
25218910	0	enoyl-acyl	74,84	InhA	112,116	enoyl-acyl	InhA	null	16322(Tax:10090)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Development of 2 - -LRB- 4-oxoquinazolin-3 -LRB- 4H -RRB- - yl -RRB- acetamide derivatives as novel enoyl-acyl carrier protein reductase -LRB- InhA -RRB- inhibitors for the treatment of tuberculosis .
11668581	0	ensconsin	59,68	microtubule-associated_protein	27,57	ensconsin	microtubule-associated protein	null	51115	Chemical	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Abundant expression of the microtubule-associated_protein , ensconsin -LRB- E-MAP-115 -RRB- , alters the cellular response to Taxol .
21884778	0	ent-kaur-16-en-19-oic_Acid	0,26	Nrf2	99,103	ent-kaur-16-en-19-oic Acid	Nrf2	MESH:C014341	18024(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|nmod|END_ENTITY	ent-kaur-16-en-19-oic_Acid , isolated from the roots of Aralia continentalis , induces activation of Nrf2 .
10410761	0	entacapone	21,31	COMT	0,4	entacapone	COMT	MESH:C071192	1312	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|END_ENTITY	COMT inhibition with entacapone in the treatment of Parkinson 's _ disease .
11865133	0	entacapone	35,45	COMT	0,4	entacapone	COMT	MESH:C071192	1312	Chemical	Gene	genotype|nmod|START_ENTITY END_ENTITY|dobj|genotype	COMT genotype and effectiveness of entacapone in patients with fluctuating Parkinson 's _ disease .
12959293	0	entacapone	34,44	COMT	19,23	entacapone	COMT	MESH:C071192	1312	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|inhibitor inhibitor|amod|END_ENTITY	The effects of the COMT inhibitor entacapone on haemodynamics and peripheral catecholamine metabolism during exercise .
15177064	0	entacapone	35,45	COMT	14,18	entacapone	COMT	MESH:C071192	1312	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|effect effect|nmod|END_ENTITY	The effect of COMT inhibition with entacapone on cardiorespiratory responses to exercise in patients with Parkinson 's _ disease .
15340869	0	entacapone	44,54	COMT	23,27	entacapone	COMT	MESH:C071192	1312	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Clinical advantages of COMT inhibition with entacapone - a review .
15614425	0	entacapone	20,30	COMT	4,8	entacapone	COMT	MESH:C071192	24267(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	The COMT inhibitor , entacapone , reduces levodopa-induced elevations in plasma homocysteine in healthy adult rats .
21280081	0	entacapone	56,66	COMT	4,8	entacapone	COMT	MESH:C071192	1312	Chemical	Gene	response|acl|START_ENTITY affects|dobj|response affects|nsubj|polymorphism polymorphism|compound|END_ENTITY	The COMT Val158Met polymorphism affects the response to entacapone in Parkinson 's _ disease : a randomized crossover clinical trial .
7874370	0	entacapone	29,39	COMT	0,4	entacapone	COMT	MESH:C071192	1312	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	COMT inhibition by high-dose entacapone does not affect hemodynamics but changes catecholamine metabolism in healthy volunteers at rest and during exercise .
8112370	0	entacapone	10,20	COMT	24,28	entacapone	COMT	MESH:C071192	1312	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effect of entacapone , a COMT inhibitor , on the pharmacokinetics of levodopa and on cardiovascular responses in patients with Parkinson 's _ disease .
8290096	0	entacapone	10,20	COMT	24,28	entacapone	COMT	MESH:C071192	1312	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effect of entacapone , a COMT inhibitor , on clinical disability and levodopa metabolism in parkinsonian patients .
8665534	0	entacapone	10,20	COMT	24,28	entacapone	COMT	MESH:C071192	1312	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effect of entacapone , a COMT inhibitor , on the pharmacokinetics and metabolism of levodopa after administration of controlled-release levodopa-carbidopa in volunteers .
8836934	0	entacapone	19,29	COMT	0,4	entacapone	COMT	MESH:C071192	1312	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	COMT inhibition by entacapone does not affect growth_hormone or prolactin secretion in healthy volunteers .
9610919	0	entacapone	86,96	COMT	70,74	entacapone	COMT	MESH:C071192	24267(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Conditioned place preference induced by a combination of L-dopa and a COMT inhibitor , entacapone , in rats .
9620057	0	entacapone	64,74	COMT	43,47	entacapone	COMT	MESH:C071192	1312	Chemical	Gene	-LSB-|nmod|START_ENTITY -LSB-|nmod|inhibition inhibition|amod|END_ENTITY	Striatal -LSB- 18F -RSB- fluorodopa utilization after COMT inhibition with entacapone studied with PET in advanced Parkinson 's _ disease .
9681662	0	entacapone	77,87	Catechol-O-methyltransferase	0,28	entacapone	Catechol-O-methyltransferase	MESH:C071192	1312	Chemical	Gene	variation|nmod|START_ENTITY END_ENTITY|dep|variation	Catechol-O-methyltransferase : variation in enzyme activity and inhibition by entacapone and tolcapone .
8477410	0	entacapone	58,68	catechol-O-methyl_transferase	14,43	entacapone	catechol-O-methyl transferase	MESH:C071192	1312	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	The effect of catechol-O-methyl_transferase inhibition by entacapone on the pharmacokinetics and metabolism of levodopa in healthy volunteers .
11290882	0	entacapone	59,69	catechol-O-methyltransferase	14,42	entacapone	catechol-O-methyltransferase	MESH:C071192	1312	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|inhibition inhibition|amod|END_ENTITY	The effect of catechol-O-methyltransferase inhibition with entacapone on cardiovascular autonomic responses in L-Dopa-treated patients with Parkinson 's _ disease .
11294372	0	entacapone	20,30	catechol-O-methyltransferase	54,82	entacapone	catechol-O-methyltransferase	MESH:C071192	1312	Chemical	Gene	Pharmacokinetics|nmod|START_ENTITY Pharmacokinetics|appos|peripherally peripherally|acl|acting acting|dobj|inhibitor inhibitor|amod|END_ENTITY	Pharmacokinetics of entacapone , a peripherally acting catechol-O-methyltransferase inhibitor , in man .
11994054	0	entacapone	53,63	catechol-O-methyltransferase	14,42	entacapone	catechol-O-methyltransferase	MESH:C071192	1312	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|inhibitor inhibitor|amod|END_ENTITY	Effect of the catechol-O-methyltransferase inhibitor entacapone on the steady-state pharmacokinetics and pharmacodynamics of warfarin .
1407012	0	entacapone	107,117	catechol-O-methyltransferase	68,96	entacapone	catechol-O-methyltransferase	MESH:C071192	24267(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|properties properties|nmod|inhibitor inhibitor|amod|END_ENTITY	Biochemical and pharmacological properties of a peripherally acting catechol-O-methyltransferase inhibitor entacapone .
8020535	0	entacapone	90,100	catechol-O-methyltransferase	51,79	entacapone	catechol-O-methyltransferase	MESH:C071192	445450(Tax:9615)	Chemical	Gene	START_ENTITY|nsubj|Identification Identification|nmod|metabolites metabolites|nmod|inhibitor inhibitor|amod|END_ENTITY	Identification of major urinary metabolites of the catechol-O-methyltransferase inhibitor entacapone in the dog .
8039535	0	entacapone	129,139	catechol-O-methyltransferase	22,50	entacapone	catechol-O-methyltransferase	MESH:C071192	1312	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of soluble catechol-O-methyltransferase and single-dose pharmacokinetics after oral and intravenous administration of entacapone .
8095232	0	entacapone	82,92	catechol-O-methyltransferase	43,71	entacapone	catechol-O-methyltransferase	MESH:C071192	24267(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Identification Identification|nmod|metabolites metabolites|nmod|inhibitor inhibitor|amod|END_ENTITY	Identification of major metabolites of the catechol-O-methyltransferase inhibitor entacapone in rats and humans .
8126502	0	entacapone	10,20	catechol-O-methyltransferase	44,72	entacapone	catechol-O-methyltransferase	MESH:C071192	1312	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|peripherally peripherally|acl|acting acting|dobj|inhibitor inhibitor|amod|END_ENTITY	Effect of entacapone , a peripherally acting catechol-O-methyltransferase inhibitor , on the motor response to acute treatment with levodopa in patients with Parkinson 's _ disease .
8726541	0	entacapone	97,107	catechol-O-methyltransferase	57,85	entacapone	catechol-O-methyltransferase	MESH:C071192	1312	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Effect of one month 's treatment with peripherally acting catechol-O-methyltransferase inhibitor , entacapone , on pharmacokinetics and motor response to levodopa in advanced parkinsonian patients .
21164341	0	entacapone	97,107	catechol-o-methyl_transferase	13,42	entacapone	catechol-o-methyl transferase	MESH:C071192	1312	Chemical	Gene	up-regulated|nmod|START_ENTITY up-regulated|nsubjpass|activity activity|amod|END_ENTITY	Erythrocytes catechol-o-methyl_transferase activity is up-regulated after a 3-month treatment by entacapone in parkinsonian patients .
25707935	0	entecavir	86,95	a-fetoprotein	69,82	entecavir	a-fetoprotein	MESH:C413685	174	Chemical	Gene	therapy|compound|START_ENTITY END_ENTITY|nmod|therapy	Prediction of risk for hepatocellular_carcinoma by response of serum a-fetoprotein to entecavir therapy .
24123097	0	entecavir	134,143	alpha-fetoprotein	13,30	entecavir	alpha-fetoprotein	MESH:C413685	174	Chemical	Gene	receiving|dobj|START_ENTITY chronic_hepatitis_B|acl|receiving patients|nmod|chronic_hepatitis_B hepatocellular_carcinoma|nmod|patients marker|nmod|hepatocellular_carcinoma marker|nsubj|END_ENTITY	On-treatment alpha-fetoprotein is a specific tumor marker for hepatocellular_carcinoma in patients with chronic_hepatitis_B receiving entecavir .
25384794	0	entecavir	75,84	alpha-fetoprotein	10,27	entecavir	alpha-fetoprotein	MESH:C413685	174	Chemical	Gene	treatment|compound|START_ENTITY END_ENTITY|nmod|treatment	Impact of alpha-fetoprotein on hepatocellular_carcinoma development during entecavir treatment of chronic hepatitis_B_virus infection .
21996197	0	enteric-coated_mycophenolate_sodium	13,48	calcineurin_inhibitor	69,90	enteric-coated mycophenolate sodium	calcineurin inhibitor	null	23523	Chemical	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	Tolerance of enteric-coated_mycophenolate_sodium in combination with calcineurin_inhibitor in kidney transplant recipients : Polish experience .
15312796	0	enterostatin	9,21	c-Fos	30,35	enterostatin	c-Fos	null	314322(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Amygdala enterostatin induces c-Fos expression in regions of hypothalamus that innervate the PVN .
9725641	0	enterostatin	33,45	insulin	14,21	enterostatin	insulin	null	3630	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of insulin release by enterostatin .
10691917	0	enterotoxin	21,32	IL-8	59,63	enterotoxin	IL-8	MESH:D004768	3576	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Bacteroides_fragilis enterotoxin induces the expression of IL-8 and transforming_growth_factor-beta -LRB- TGF-beta -RRB- by human colonic epithelial cells .
20231411	0	enterotoxin	21,32	beta-defensin-2	47,62	enterotoxin	beta-defensin-2	MESH:D004768	1673	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Bacteroides_fragilis enterotoxin induces human beta-defensin-2 expression in intestinal epithelial cells via a mitogen-activated protein kinase/I kappaB kinase/NF-kappaB-dependent pathway .
15453261	0	enterotoxin_B	82,95	Fos	0,3	enterotoxin B	Fos	null	314322(Tax:10116)	Chemical	Gene	injection|nmod|START_ENTITY END_ENTITY|nmod|injection	Fos expression in the rat brain after intraperitoneal injection of Staphylococcus enterotoxin_B and the effect of vagotomy .
9741348	0	enterotoxin_B	15,28	interleukin-4	56,69	enterotoxin B	interleukin-4	null	3565	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|nmod|END_ENTITY	Staphylococcal enterotoxin_B inhibits the production of interleukin-4 in a human mast-cell line HMC-1 .
26932782	0	enzalutamide	44,56	AR	31,33	enzalutamide	AR	MESH:C540278	367	Chemical	Gene	START_ENTITY|nsubj|evaluation evaluation|nmod|inhibitor inhibitor|compound|END_ENTITY	Pre-clinical evaluation of the AR inhibitor enzalutamide in triple negative breast_cancer cells .
23117885	0	enzalutamide	42,54	Androgen_receptor	0,17	enzalutamide	Androgen receptor	MESH:C540278	367	Chemical	Gene	resistance|amod|START_ENTITY mediate|dobj|resistance splice|ccomp|mediate splice|nsubj|END_ENTITY	Androgen_receptor splice variants mediate enzalutamide resistance in castration-resistant_prostate_cancer cell lines .
25048254	0	enzalutamide	48,60	Androgen_receptor	0,17	enzalutamide	Androgen receptor	MESH:C540278	367	Chemical	Gene	era|nmod|START_ENTITY variants|nmod|era variants|nsubj|splice splice|compound|END_ENTITY	Androgen_receptor splice variants in the era of enzalutamide and abiraterone .
23699654	0	enzalutamide	33,45	androgen_receptor	74,91	enzalutamide	androgen receptor	MESH:C540278	367	Chemical	Gene	induces|advcl|START_ENTITY induces|parataxis|role role|nmod|END_ENTITY	NF-kB2 / p52 induces resistance to enzalutamide in prostate_cancer : role of androgen_receptor and its variants .
23779130	0	enzalutamide	103,115	androgen_receptor	22,39	enzalutamide	androgen receptor	MESH:C540278	367	Chemical	Gene	antiandrogens|amod|START_ENTITY confers|nmod|antiandrogens confers|nsubj|mutation mutation|compound|END_ENTITY	A clinically relevant androgen_receptor mutation confers resistance to second-generation antiandrogens enzalutamide and ARN-509 .
23842682	0	enzalutamide	93,105	androgen_receptor	21,38	enzalutamide	androgen receptor	MESH:C540278	367	Chemical	Gene	MDV3100|appos|START_ENTITY confers|nmod|MDV3100 confers|nsubj|mutation mutation|nmod|END_ENTITY	An F876L mutation in androgen_receptor confers genetic and phenotypic resistance to MDV3100 -LRB- enzalutamide -RRB- .
24451109	0	enzalutamide	75,87	androgen_receptor	12,29	enzalutamide	androgen receptor	MESH:C540278	367	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of the androgen_receptor in breast_cancer and preclinical analysis of enzalutamide .
27036029	0	enzalutamide	74,86	androgen_receptor	45,62	enzalutamide	androgen receptor	MESH:C540278	367	Chemical	Gene	START_ENTITY|nsubj|resistance resistance|nmod|antagonist antagonist|compound|END_ENTITY	Acquired resistance to the second-generation androgen_receptor antagonist enzalutamide in castration-resistant prostate_cancer .
16645590	0	enzastaurin	46,57	AKT	128,131	enzastaurin	AKT	MESH:C504878	207	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|pathway pathway|compound|END_ENTITY	The selective protein kinase C beta inhibitor enzastaurin induces apoptosis in cutaneous_T-cell_lymphoma cell lines through the AKT pathway .
23992368	0	enzastaurin	54,65	p90RSK	28,34	enzastaurin	p90RSK	MESH:C504878	20112(Tax:10090)	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	The serine-threonine kinase p90RSK is a new target of enzastaurin in follicular_lymphoma cells .
16943527	0	enzastaurin	53,64	protein_kinase_C_beta	74,95	enzastaurin	protein kinase C beta	MESH:C504878	5579	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Phase I dose escalation and pharmacokinetic study of enzastaurin , an oral protein_kinase_C_beta inhibitor , in patients with advanced_cancer .
14577151	0	eosin_Y	11,18	ATPase	33,39	eosin Y	ATPase	MESH:D004801	1769	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|END_ENTITY	-LSB- Effect of eosin_Y on Ca2 + , Mg2 + - ATPase of the smooth muscle sarcolemma -RSB- .
16846071	0	eosin_Y	11,18	ATPase	22,28	eosin Y	ATPase	MESH:D004801	1769	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	-LSB- Effect of eosin_Y on ATPase activity of actomyosine complex of the uterus smooth muscle -RSB- .
2307116	0	ephedrine	124,133	adipsin	8,15	ephedrine	adipsin	MESH:D004809	11537(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY expression|dep|effect expression|compound|END_ENTITY	Reduced adipsin expression in murine obesity : effect of age and treatment with the sympathomimetic-thermogenic drug mixture ephedrine and caffeine .
844601	1	epiallo-desethermuscarine	65,90	VIII	23,27	epiallo-desethermuscarine	VIII	null	1351	Chemical	Gene	Synthesis|nmod|START_ENTITY Synthesis|compound|END_ENTITY	VIII Synthesis and biological activity of epiallo-desethermuscarine .
20963498	0	epigallocatechin-3-O-gallate	49,77	p53	95,98	epigallocatechin-3-O-gallate	p53	CHEBI:4806	7157	Chemical	Gene	START_ENTITY|nmod|induction induction|nmod|END_ENTITY	Apoptosis of human fibrosarcoma HT-1080 cells by epigallocatechin-3-O-gallate via induction of p53 and caspases as well as suppression of Bcl-2 and phosphorylated nuclear factor-kB .
15455372	0	epigallocatechin-3-gallate	22,48	COX-2	70,75	epigallocatechin-3-gallate	COX-2	MESH:C045651	4513	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Green tea constituent epigallocatechin-3-gallate selectively inhibits COX-2 without affecting COX-1 expression in human prostate_carcinoma cells .
19597830	0	epigallocatechin-3-gallate	103,129	IL-8	46,50	epigallocatechin-3-gallate	IL-8	MESH:C045651	3576	Chemical	Gene	effect|nmod|START_ENTITY keratinocytes|nmod|effect reduces|nmod|keratinocytes reduces|dobj|levels levels|compound|END_ENTITY	Gingko_biloba extract reduces VEGF and CXCL-8 / IL-8 levels in keratinocytes with cumulative effect with epigallocatechin-3-gallate .
16390465	0	epigallocatechin-3-gallate	69,95	MMP-13	105,111	epigallocatechin-3-gallate	MMP-13	MESH:C045651	4322	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Increase of MMP-13 expression in multi-stage oral carcinogenesis and epigallocatechin-3-gallate suppress MMP-13 expression .
18850185	0	epigallocatechin-3-gallate	21,47	STAT1	103,108	epigallocatechin-3-gallate	STAT1	MESH:C045651	6772	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|END_ENTITY	Protective effect of epigallocatechin-3-gallate on ischemia/reperfusion-induced injuries in the heart : STAT1 silencing flavonoid .
15033450	0	epigallocatechin-3-gallate	18,44	VCAM-1	70,76	epigallocatechin-3-gallate	VCAM-1	MESH:C045651	7412	Chemical	Gene	tea|amod|START_ENTITY reduces|nsubj|tea reduces|dobj|expression expression|compound|END_ENTITY	The tea flavonoid epigallocatechin-3-gallate reduces cytokine-induced VCAM-1 expression and monocyte adhesion to endothelial cells .
14996703	0	epigallocatechin-3-gallate	90,116	VEGF	0,4	epigallocatechin-3-gallate	VEGF	MESH:C045651	7422	Chemical	Gene	component|appos|START_ENTITY modulated|nmod|component modulated|nsubjpass|status status|compound|END_ENTITY	VEGF receptor phosphorylation status and apoptosis is modulated by a green tea component , epigallocatechin-3-gallate -LRB- EGCG -RRB- , in B-cell_chronic_lymphocytic_leukemia .
19597830	0	epigallocatechin-3-gallate	103,129	VEGF	30,34	epigallocatechin-3-gallate	VEGF	MESH:C045651	7422	Chemical	Gene	effect|nmod|START_ENTITY keratinocytes|nmod|effect reduces|nmod|keratinocytes reduces|dobj|levels levels|compound|END_ENTITY	Gingko_biloba extract reduces VEGF and CXCL-8 / IL-8 levels in keratinocytes with cumulative effect with epigallocatechin-3-gallate .
24035571	0	epigallocatechin-3-gallate	122,148	connective_tissue_growth_factor	35,66	epigallocatechin-3-gallate	connective tissue growth factor	MESH:C045651	1490	Chemical	Gene	Inhibition|nmod|START_ENTITY expression|dep|Inhibition expression|compound|END_ENTITY	Sphingosine-1-phosphate stimulated connective_tissue_growth_factor expression in human buccal fibroblasts : Inhibition by epigallocatechin-3-gallate .
24009859	0	epigallocatechin-3-gallate	22,48	cyclooxygenase-1	63,79	epigallocatechin-3-gallate	cyclooxygenase-1	MESH:C045651	5742	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Inhibitory effects of epigallocatechin-3-gallate on microsomal cyclooxygenase-1 activity in platelets .
26189955	0	epigallocatechin-3-gallate	20,46	osteopontin	71,82	epigallocatechin-3-gallate	osteopontin	MESH:C045651	6696	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|nmod|END_ENTITY	Green tea component epigallocatechin-3-gallate decreases expression of osteopontin via a decrease in mRNA half-life in cell lines of metastatic hepatocellular_carcinoma .
21821246	0	epigallocatechin-3-gallate	10,36	vascular_endothelial_growth_factor_C	74,110	epigallocatechin-3-gallate	vascular endothelial growth factor C	MESH:C045651	7424	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Green tea epigallocatechin-3-gallate inhibits angiogenesis and suppresses vascular_endothelial_growth_factor_C / vascular endothelial growth factor receptor 2 expression and signaling in experimental endometriosis in vivo .
19782057	0	epigallocatechin_gallate	21,45	C-reactive_protein	67,85	epigallocatechin gallate	C-reactive protein	MESH:C045651	25419(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|nmod|END_ENTITY	Regulatory effect of epigallocatechin_gallate on the expression of C-reactive_protein and other inflammatory markers in an experimental model of atherosclerosis .
23322423	0	epigallocatechin_gallate	60,84	ER-a	41,45	epigallocatechin gallate	ER-a	MESH:C045651	2099	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	In vitro mechanism for downregulation of ER-a expression by epigallocatechin_gallate in ER + / PR + human breast_cancer cells .
24745965	0	epigallocatechin_gallate	35,59	Hsp90	71,76	epigallocatechin gallate	Hsp90	MESH:C045651	3320	Chemical	Gene	analogs|compound|START_ENTITY analogs|nmod|inhibitors inhibitors|amod|END_ENTITY	Towards the discovery of drug-like epigallocatechin_gallate analogs as Hsp90 inhibitors .
17201629	0	epigallocatechin_gallate	55,79	catechol-O-methyltransferase	94,122	epigallocatechin gallate	catechol-O-methyltransferase	MESH:C045651	1312	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Green tea extract thermogenesis-induced weight_loss by epigallocatechin_gallate inhibition of catechol-O-methyltransferase .
11700039	0	epigallocatechin_gallate	10,34	fatty-acid_synthase	59,78	epigallocatechin gallate	fatty-acid synthase	MESH:C045651	396061(Tax:9031)	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	Green tea epigallocatechin_gallate : a natural inhibitor of fatty-acid_synthase .
9393670	0	epigallocatechin_gallate	85,109	inducible_nitric_oxide_synthase	14,45	epigallocatechin gallate	inducible nitric oxide synthase	MESH:C045651	18126(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Inhibition of inducible_nitric_oxide_synthase gene expression and enzyme activity by epigallocatechin_gallate , a natural product from green tea .
7645988	0	epigallocatechin_gallate	15,39	interleukin-1	43,56	epigallocatechin gallate	interleukin-1	MESH:C045651	3552	Chemical	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Stimulation by epigallocatechin_gallate of interleukin-1 production by human peripheral blood mononuclear cells .
24695276	0	epigallocatechin_gallate	10,34	proton-coupled_folate_transporter	69,102	epigallocatechin gallate	proton-coupled folate transporter	MESH:C045651	113235	Chemical	Gene	Effect|nmod|START_ENTITY mediated|nsubj|Effect mediated|nmod|END_ENTITY	Effect of epigallocatechin_gallate on drug transport mediated by the proton-coupled_folate_transporter .
15713670	0	epigallocatechin_gallate	63,87	vimentin	34,42	epigallocatechin gallate	vimentin	MESH:C045651	7431	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	The intermediate filament protein vimentin is a new target for epigallocatechin_gallate .
16102259	0	epinastine_hydrochloride	24,48	TARC	52,56	epinastine hydrochloride	TARC	MESH:C053090	6361	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Suppressive activity of epinastine_hydrochloride on TARC production from human peripheral blood CD4 + T cells in-vitro .
6301454	0	epinephrine	20,31	CRF	68,71	epinephrine	CRF	MESH:D004837	81648(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Additive effects of epinephrine and corticotropin-releasing_factor -LRB- CRF -RRB- on adrenocorticotropin release in rat anterior pituitary cells .
21651344	0	epinephrine	62,73	Endothelin-1	0,12	epinephrine	Endothelin-1	MESH:D004837	396915(Tax:9823)	Chemical	Gene	attenuates|nmod|START_ENTITY attenuates|nsubj|END_ENTITY	Endothelin-1 attenuates the hemodynamic response to exogenous epinephrine in a porcine ischemic ventricular_fibrillation cardiac_arrest model .
11085369	0	epinephrine	10,21	GLUT2	25,30	epinephrine	GLUT2	MESH:D004837	20526(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|content content|compound|END_ENTITY	Effect of epinephrine on GLUT2 protein content in mouse liver .
2154021	0	epinephrine	60,71	Insulin	0,7	epinephrine	Insulin	MESH:D004837	100379579(Tax:10141)	Chemical	Gene	induced|nmod|START_ENTITY force|acl|induced inhibits|dobj|force inhibits|nsubj|END_ENTITY	Insulin inhibits the increased contractile force induced by epinephrine in isolated guinea_pig heart muscle .
215492	0	epinephrine	22,33	Insulin	0,7	epinephrine	Insulin	MESH:D004837	3630	Chemical	Gene	action|amod|START_ENTITY alteration|nmod|action alteration|compound|END_ENTITY	Insulin alteration of epinephrine action on the heart .
517645	0	epinephrine	32,43	Insulin	0,7	epinephrine	Insulin	MESH:D004837	483665(Tax:9615)	Chemical	Gene	effects|nmod|START_ENTITY effects|amod|END_ENTITY	Insulin antagonistic effects of epinephrine and glucagon in the dog .
9500557	0	epinephrine	19,30	Insulin	0,7	epinephrine	Insulin	MESH:D004837	3630	Chemical	Gene	release|amod|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Insulin stimulates epinephrine release under euglycemic conditions in humans .
3309520	0	epinephrine	55,66	Renin	0,5	epinephrine	Renin	MESH:D004837	403838(Tax:9615)	Chemical	Gene	incubation|nmod|START_ENTITY dogs|nmod|incubation secretion|nmod|dogs secretion|nsubj|END_ENTITY	Renin secretion in intact dogs following incubation of epinephrine in blood in vivo .
16542483	0	epinephrine	26,37	Vasopressin	0,11	epinephrine	Vasopressin	MESH:D004837	551	Chemical	Gene	combined|nmod|START_ENTITY END_ENTITY|acl|combined	Vasopressin combined with epinephrine during cardiac resuscitation : a solution for the future ?
1064147	0	epinephrine	10,21	gastrin	44,51	epinephrine	gastrin	MESH:D004837	2520	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|release release|compound|END_ENTITY	Effect of epinephrine and norepinephrine on gastrin release and gastric secretion of acid in man .
1547916	0	epinephrine	95,106	insulin	32,39	epinephrine	insulin	MESH:D004837	3630	Chemical	Gene	effects|acl|START_ENTITY effects|nmod|concentrations concentrations|compound|END_ENTITY	The effects of different plasma insulin concentrations on lipolytic and ketogenic responses to epinephrine in normal and type 1 -LRB- insulin-dependent -RRB- diabetic humans .
1640844	0	epinephrine	18,29	insulin	53,60	epinephrine	insulin	MESH:D004837	3630	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|role role|nmod|END_ENTITY	Thermic effect of epinephrine : a role for endogenous insulin .
2837460	0	epinephrine	49,60	insulin	28,35	epinephrine	insulin	MESH:D004837	3630	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|inhibition inhibition|nmod|END_ENTITY	GTP-dependent inhibition of insulin secretion by epinephrine in permeabilized RINm5F cells .
365654	0	epinephrine	54,65	insulin	82,89	epinephrine	insulin	MESH:D004837	3630	Chemical	Gene	modification|amod|START_ENTITY modification|nmod|release release|compound|END_ENTITY	Effects of calcium , lanthanum , and bicarbonate ion on epinephrine modification of insulin release in vitro .
3891786	0	epinephrine	36,47	insulin	129,136	epinephrine	insulin	MESH:D004837	3630	Chemical	Gene	responsiveness|acl|START_ENTITY result|nsubj|responsiveness result|nmod|inability inability|acl|secrete secrete|dobj|END_ENTITY	Enhanced glycemic responsiveness to epinephrine in insulin-dependent_diabetes_mellitus is the result of the inability to secrete insulin .
3891786	1	epinephrine	244,255	insulin	148,155	epinephrine	insulin	MESH:D004837	3630	Chemical	Gene	limits|advcl|START_ENTITY limits|nsubj|secretion secretion|compound|END_ENTITY	Augmented insulin secretion normally limits the glycemic , but not the lipolytic or ketogenic , response to epinephrine in humans .
611092	0	epinephrine	10,21	insulin	24,31	epinephrine	insulin	MESH:D004837	3630	Chemical	Gene	Effect|nmod|START_ENTITY _|nsubj|Effect _|dobj|END_ENTITY	Effect of epinephrine _ insulin on phosphorylase activity in relation to subcellular electromigration in the amphibian gastrocnemius muscle .
7789632	0	epinephrine	32,43	insulin	91,98	epinephrine	insulin	MESH:D004837	483665(Tax:9615)	Chemical	Gene	increase|nmod|START_ENTITY Effects|nmod|increase Effects|nmod|deficiency deficiency|compound|END_ENTITY	Effects of an acute increase in epinephrine and cortisol on carbohydrate metabolism during insulin deficiency .
8425666	0	epinephrine	11,22	insulin	26,33	epinephrine	insulin	MESH:D004837	3630	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of epinephrine on insulin secretion and action in humans .
12871375	0	epinephrine	24,35	interleukin-8	66,79	epinephrine	interleukin-8	MESH:D004837	3576	Chemical	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	The promoting effect of epinephrine on lipopolysaccharide-induced interleukin-8 production in whole blood may be mediated by thromboxane_A2 .
11786596	0	epinephrine	29,40	leptin	7,13	epinephrine	leptin	MESH:D004837	3952	Chemical	Gene	infusion|amod|START_ENTITY END_ENTITY|nmod|infusion	Plasma leptin response to an epinephrine infusion in lean and obese women .
2854048	0	epinephrine	113,124	liver_glycogen_phosphorylase	81,109	epinephrine	liver glycogen phosphorylase	MESH:D004837	64035(Tax:10116)	Chemical	Gene	infusion|amod|START_ENTITY END_ENTITY|nmod|infusion	Dose dependent reversal by i.v. glucose administration of the stimulation of rat liver_glycogen_phosphorylase by epinephrine infusion .
6543193	0	epinephrine	11,22	parathyroid_hormone	51,70	epinephrine	parathyroid hormone	MESH:D004837	5741	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of epinephrine and norepinephrine on serum parathyroid_hormone and calcium in normal subjects .
23224622	0	epinephrine	226,237	phenylethanolamine_N-methyltransferase	138,176	epinephrine	phenylethanolamine N-methyltransferase	MESH:D004837	5409	Chemical	Gene	synthesis|nmod|START_ENTITY responsible|nmod|synthesis enzyme|amod|responsible ultra|appos|enzyme ultra|dep|content content|nmod|END_ENTITY	Double stable isotope ultra performance liquid chromatographic-tandem mass spectrometric quantification of tissue content and activity of phenylethanolamine_N-methyltransferase , the crucial enzyme responsible for synthesis of epinephrine .
3372503	0	epinephrine	130,141	phenylethanolamine_N-methyltransferase	75,113	epinephrine	phenylethanolamine N-methyltransferase	MESH:D004837	5409	Chemical	Gene	biosynthesis|amod|START_ENTITY enzyme|nmod|biosynthesis END_ENTITY|appos|enzyme	Molecular cloning of cDNA and chromosomal assignment of the gene for human phenylethanolamine_N-methyltransferase , the enzyme for epinephrine biosynthesis .
6872952	0	epinephrine	36,47	phenylethanolamine_N-methyltransferase	69,107	epinephrine	phenylethanolamine N-methyltransferase	MESH:D004837	24661(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|regulation regulation|nmod|synthesis synthesis|amod|END_ENTITY	The role of compartmentalization of epinephrine in the regulation of phenylethanolamine_N-methyltransferase synthesis in rat adrenal medulla .
744091	0	epinephrine	14,25	phenylethanolamine_N-methyltransferase	29,67	epinephrine	phenylethanolamine N-methyltransferase	MESH:D004837	5409	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of epinephrine on phenylethanolamine_N-methyltransferase in cultured explants of adrenal medulla .
7047346	0	epinephrine	78,89	protein-supplemented_fasting	10,38	epinephrine	protein-supplemented fasting	MESH:D004837	3490	Chemical	Gene	Effect|acl|START_ENTITY Effect|nmod|END_ENTITY	Effect of protein-supplemented_fasting on metabolic and hormonal responses to epinephrine infusion in obese subjects .
2665519	0	epinephrine	30,41	renin	72,77	epinephrine	renin	MESH:D004837	403838(Tax:9615)	Chemical	Gene	concentration|compound|START_ENTITY increases|nmod|concentration modulate|nsubj|increases modulate|dobj|release release|compound|END_ENTITY	Sustained increases in plasma epinephrine concentration do not modulate renin release .
3521329	0	epinephrine	20,31	renin	63,68	epinephrine	renin	MESH:D004837	403838(Tax:9615)	Chemical	Gene	nerves|amod|START_ENTITY Interaction|nmod|nerves Interaction|nmod|rate rate|amod|END_ENTITY	Interaction between epinephrine and renal nerves in control of renin secretion rate .
3892214	0	epinephrine	22,33	renin	53,58	epinephrine	renin	MESH:D004837	403838(Tax:9615)	Chemical	Gene	infusion|compound|START_ENTITY Effect|nmod|infusion Effect|nmod|activity activity|compound|END_ENTITY	Effect of intravenous epinephrine infusion on plasma renin activity in adrenalectomized dogs .
4304350	0	epinephrine	44,55	renin	24,29	epinephrine	renin	MESH:D004837	5972	Chemical	Gene	vitro|nmod|START_ENTITY vitro|dobj|stimulation stimulation|nmod|production production|compound|END_ENTITY	In vitro stimulation of renin production by epinephrine , norepinephrine , and cyclic_AMP .
443450	0	epinephrine	7,18	renin	41,46	epinephrine	renin	MESH:D004837	403838(Tax:9615)	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Plasma epinephrine and control of plasma renin activity : possible extrarenal mechanisms .
6291915	0	epinephrine	41,52	renin	7,12	epinephrine	renin	MESH:D004837	403838(Tax:9615)	Chemical	Gene	infusion|nmod|START_ENTITY END_ENTITY|nmod|infusion	Plasma renin activity during infusion of epinephrine into the celiac and superior mesenteric arteries in dogs .
6372523	0	epinephrine	12,23	renin	35,40	epinephrine	renin	MESH:D004837	403838(Tax:9615)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|compound|END_ENTITY	Circulating epinephrine stimulates renin secretion in anesthetized dogs by activation of extrarenal adrenoceptors .
7049678	0	epinephrine	41,52	renin	7,12	epinephrine	renin	MESH:D004837	403838(Tax:9615)	Chemical	Gene	infusion|nmod|START_ENTITY END_ENTITY|nmod|infusion	Plasma renin activity during infusion of epinephrine into the carotid and vertebral arteries of anesthetized dogs .
7826555	0	epinephrine	54,65	renin	16,21	epinephrine	renin	MESH:D004837	5972	Chemical	Gene	infusion|compound|START_ENTITY Dissociation|nmod|infusion Dissociation|nmod|END_ENTITY	Dissociation of renin and aldosterone during low-dose epinephrine infusion .
10498359	0	epinephrine	35,46	thrombin	75,83	epinephrine	thrombin	MESH:D004837	2147	Chemical	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	Effect of topical and subcutaneous epinephrine in combination with topical thrombin in blood_loss during immediate near-total burn wound excision in pediatric burned patients .
2845924	0	epinephrine	43,54	thrombin	18,26	epinephrine	thrombin	MESH:D004837	2147	Chemical	Gene	Synergism|appos|START_ENTITY Synergism|nmod|END_ENTITY	Synergism between thrombin and adrenaline -LRB- epinephrine -RRB- in human platelets .
118391	0	epinephrine	104,115	thyrotropin-releasing_hormone	55,84	epinephrine	thyrotropin-releasing hormone	MESH:D004837	7200	Chemical	Gene	infusion|nmod|START_ENTITY END_ENTITY|nmod|infusion	Thyroid-stimulating hormone and prolactin responses to thyrotropin-releasing_hormone during infusion of epinephrine and propranolol in man .
25957836	0	epinephrine	4,15	tyrosine_hydroxylase	26,46	epinephrine	tyrosine hydroxylase	MESH:D004837	25085(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	The epinephrine increases tyrosine_hydroxylase expression through upregulating thioredoxin-1 in PC12 cells .
6115746	0	epinephrine	21,32	tyrosine_hydroxylase	61,81	epinephrine	tyrosine hydroxylase	MESH:D004837	25085(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|development development|nmod|activity activity|amod|END_ENTITY	Influence of adrenal epinephrine on postnatal development of tyrosine_hydroxylase activity in the superior cervical ganglion .
21053189	0	epinephrine	92,103	vasopressin	66,77	epinephrine	vasopressin	MESH:D004837	551	Chemical	Gene	combined|nmod|START_ENTITY END_ENTITY|acl|combined	Comparison of two protocols for pulseless cardiopulmonary_arrest : vasopressin combined with epinephrine versus epinephrine alone .
23108394	0	epirubicin	80,90	BRIP1	38,43	epirubicin	BRIP1	MESH:D015251	83990	Chemical	Gene	treatment|compound|START_ENTITY expression|nmod|treatment expression|compound|END_ENTITY	The Forkhead_Box_M1 protein regulates BRIP1 expression and DNA damage repair in epirubicin treatment .
26344694	0	epirubicin	26,36	Forkhead_box_K2	0,15	epirubicin	Forkhead box K2	MESH:D015251	3607	Chemical	Gene	sensitivity|compound|START_ENTITY modulates|dobj|sensitivity modulates|nsubj|END_ENTITY	Forkhead_box_K2 modulates epirubicin and paclitaxel sensitivity through FOXO3a in breast_cancer .
26767845	0	epirubicin	58,68	P-gp	44,48	epirubicin	P-gp	MESH:D015251	5243	Chemical	Gene	resistance|compound|START_ENTITY resistance|amod|END_ENTITY	Enhanced autophagy reveals vulnerability of P-gp mediated epirubicin resistance in triple_negative_breast_cancer cells .
8931678	0	epirubicin	48,58	VP-16	83,88	epirubicin	VP-16	MESH:D015251	3054	Chemical	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	Phase I study of chemotherapy with carboplatin , epirubicin , and escalating dose of VP-16 with G-CSF support in extensive small_cell_lung_cancer .
10509155	0	epirubicin	18,28	granulocyte_colony-stimulating_factor	50,87	epirubicin	granulocyte colony-stimulating factor	MESH:D015251	1440	Chemical	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	Phase II study of epirubicin and vinorelbine with granulocyte_colony-stimulating_factor : a high-activity , dose-dense weekly regimen for advanced breast_cancer .
19779097	0	epithelium_validate_KLFA	61,85	Akt	49,52	epithelium validate KLFA	Akt	null	11651(Tax:10090)	Chemical	Gene	expressing|nmod|START_ENTITY expressing|dobj|END_ENTITY	Transgenic_mice expressing constitutively active Akt in oral epithelium_validate_KLFA as a potential biomarker of head_and_neck_squamous_cell_carcinoma .
12798439	0	eplerenone	58,68	ACE	72,75	eplerenone	ACE	MESH:C414690	24310(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|compound|END_ENTITY	Addition of the selective aldosterone receptor antagonist eplerenone to ACE inhibition in heart_failure : effect on endothelial_dysfunction .
12433801	0	eplerenone	42,52	CYP3A	15,20	eplerenone	CYP3A	MESH:C414690	1576	Chemical	Gene	metabolism|nmod|START_ENTITY END_ENTITY|nmod|metabolism	Involvement of CYP3A in the metabolism of eplerenone in humans and dogs : differential metabolism by CYP3A4 and CYP3A5 .
24739799	0	eplerenone	10,20	insulin	24,31	eplerenone	insulin	MESH:C414690	3630	Chemical	Gene	START_ENTITY|nmod|action action|compound|END_ENTITY	Effect of eplerenone on insulin action in essential hypertension : a randomised , controlled , crossover study .
24615074	0	eplerenone	11,21	matrix_metalloproteinase-2	43,69	eplerenone	matrix metalloproteinase-2	MESH:C414690	4313	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Effects of eplerenone on the activation of matrix_metalloproteinase-2 stimulated by high glucose and interleukin-1b in human cardiac fibroblasts .
27065001	0	eplerenone	10,20	parathyroid_hormone	24,43	eplerenone	parathyroid hormone	MESH:C414690	5741	Chemical	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	Effect of eplerenone on parathyroid_hormone levels in patients with primary_hyperparathyroidism : results from the EPATH randomized , placebo-controlled trial .
21451213	0	eplerenone	10,20	peroxisome_proliferator_activated_receptor_gamma	88,136	eplerenone	peroxisome proliferator activated receptor gamma	MESH:C414690	25664(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|role role|nmod|END_ENTITY	Effect of eplerenone on hypertension-associated renal_damage in rats : potential role of peroxisome_proliferator_activated_receptor_gamma -LRB- PPAR-y -RRB- .
19632577	0	epoprostenol	107,119	Endothelin-1	0,12	epoprostenol	Endothelin-1	MESH:D011464	1906	Chemical	Gene	infusion|amod|START_ENTITY END_ENTITY|nmod|infusion	Endothelin-1 across the lung circulation in patients with pulmonary_arterial_hypertension and influence of epoprostenol infusion .
15281498	0	epoprostenol	111,123	Vasopressin	0,11	epoprostenol	Vasopressin	MESH:D011464	551	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|END_ENTITY	Vasopressin during spinal anesthesia in a patient with primary_pulmonary_hypertension treated with intravenous epoprostenol .
10869417	0	epoxide	37,44	CYP2E1	24,30	epoxide	CYP2E1	CHEBI:32955	13106(Tax:10090)	Chemical	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of hepatic CYP2E1 by an epoxide of diallyl_sulfone .
19321813	0	epoxide	21,28	EPHX1	40,45	epoxide	EPHX1	CHEBI:32955	13849(Tax:10090)	Chemical	Gene	hydrolase|compound|START_ENTITY hydrolase|appos|END_ENTITY	Oviductal microsomal epoxide hydrolase -LRB- EPHX1 -RRB- reduces reactive oxygen species -LRB- ROS -RRB- level and enhances preimplantation mouse embryo development .
16595607	0	epoxide	29,36	EPHX2	48,53	epoxide	EPHX2	CHEBI:32955	2053	Chemical	Gene	hydrolase|compound|START_ENTITY hydrolase|appos|END_ENTITY	Genetic variation in soluble epoxide hydrolase -LRB- EPHX2 -RRB- and risk of coronary_heart_disease : The Atherosclerosis Risk in Communities -LRB- ARIC -RRB- study .
18323494	0	epoxide	29,36	EPHX2	48,53	epoxide	EPHX2	CHEBI:32955	2053	Chemical	Gene	hydrolase|compound|START_ENTITY hydrolase|appos|END_ENTITY	Genetic variation in soluble epoxide hydrolase -LRB- EPHX2 -RRB- is associated with an increased risk of ischemic_stroke in white Europeans .
18537101	0	epoxide	32,39	EPHX2	56,61	epoxide	EPHX2	CHEBI:32955	2053	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic analysis of the soluble epoxide hydrolase gene , EPHX2 , in subclinical cardiovascular_disease in the Diabetes Heart Study .
21098312	0	epoxide	29,36	EPHX2	48,53	epoxide	EPHX2	CHEBI:32955	2053	Chemical	Gene	hydrolase|compound|START_ENTITY hydrolase|appos|END_ENTITY	Genetic variation in soluble epoxide hydrolase -LRB- EPHX2 -RRB- is associated with forearm vasodilator responses in humans .
7868134	0	epoxide	34,41	EPHX2	58,63	epoxide	EPHX2	CHEBI:32955	2053	Chemical	Gene	Localization|nmod|START_ENTITY hydrolase|nsubj|Localization hydrolase|dobj|gene gene|appos|END_ENTITY	Localization of the human soluble epoxide hydrolase gene -LRB- EPHX2 -RRB- to chromosomal region 8p21-p12 .
8619856	0	epoxide	49,56	EPHX2	73,78	epoxide	EPHX2	CHEBI:32955	2053	Chemical	Gene	characterization|nmod|START_ENTITY hydrolase|nsubj|characterization hydrolase|dobj|gene gene|appos|END_ENTITY	Structural characterization of the human soluble epoxide hydrolase gene -LRB- EPHX2 -RRB- .
24591641	0	epoxide	107,114	aminopeptidase	70,84	epoxide	aminopeptidase	CHEBI:32955	10404	Chemical	Gene	inhibitor|amod|START_ENTITY END_ENTITY|nmod|inhibitor	Binding of Pro-Gly-Pro at the active site of leukotriene_A4_hydrolase / aminopeptidase and development of an epoxide hydrolase selective inhibitor .
16866351	0	epoxide	82,89	caspase-3	55,64	epoxide	caspase-3	CHEBI:32955	836	Chemical	Gene	inhibitors|compound|START_ENTITY END_ENTITY|nmod|inhibitors	Exploring the S4 and S1 prime subsite specificities in caspase-3 with aza-peptide epoxide inhibitors .
6744285	0	epoxide	63,70	membrane-bound	36,50	epoxide	membrane-bound	CHEBI:32955	19	Chemical	Gene	activities|amod|START_ENTITY activities|amod|END_ENTITY	Measurement and characterization of membrane-bound and soluble epoxide hydrolase activities in resting mononuclear leukocytes from human blood .
12610742	0	epoxybergamottin	18,34	CYP3A4	40,46	epoxybergamottin	CYP3A4	MESH:C475527	1576	Chemical	Gene	Identification|nmod|START_ENTITY Identification|nmod|inhibitor inhibitor|compound|END_ENTITY	Identification of epoxybergamottin as a CYP3A4 inhibitor in grapefruit peel .
23766516	0	epoxyeicosatrienoic_acid	87,111	insulin	162,169	epoxyeicosatrienoic acid	insulin	CHEBI:64007	3630	Chemical	Gene	levels|amod|START_ENTITY levels|nmod|secretion secretion|compound|END_ENTITY	Diminished acyl-CoA synthetase isoform 4 activity in INS 832/13 cells reduces cellular epoxyeicosatrienoic_acid levels and results in impaired glucose-stimulated insulin secretion .
19675820	0	epoxyeicosatrienoic_acids	52,77	Insulin	0,7	epoxyeicosatrienoic acids	Insulin	CHEBI:64007	3630	Chemical	Gene	resistance|dep|START_ENTITY resistance|compound|END_ENTITY	Insulin resistance and endothelial_dysfunction : Are epoxyeicosatrienoic_acids the link ?
16315601	0	epoxyeicosatrienoic_acids	11,36	eNOS	50,54	epoxyeicosatrienoic acids	eNOS	CHEBI:64007	287024(Tax:9913)	Chemical	Gene	START_ENTITY|nmod|levels levels|nmod|END_ENTITY	Effects of epoxyeicosatrienoic_acids on levels of eNOS phosphorylation and relevant signaling transduction pathways involved .
9288184	0	epristeride	46,57	5_alpha_reductase	17,34	epristeride	5 alpha reductase	MESH:C072547	6715	Chemical	Gene	Effects|appos|START_ENTITY Effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Effects of a new 5_alpha_reductase inhibitor -LRB- epristeride -RRB- on human prostate cell cultures .
11682703	0	epristeride	10,21	IGF-1	43,48	epristeride	IGF-1	MESH:C072547	24482(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	Effect of epristeride on the expression of IGF-1 and TGF-beta receptors in androgen-induced castrated rat prostate .
12927226	0	eprosartan	18,28	AT1	0,3	eprosartan	AT1	MESH:C068373	185	Chemical	Gene	antagonism|nmod|START_ENTITY antagonism|compound|END_ENTITY	AT1 antagonism by eprosartan lowers heart rate variability and baroreflex_gain .
10321414	0	eprosartan	25,35	angiotensin_II	40,54	eprosartan	angiotensin II	MESH:C068373	183	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Assessment of once-daily eprosartan , an angiotensin_II antagonist , in patients with systemic_hypertension .
10467219	0	eprosartan	23,33	angiotensin_II	41,55	eprosartan	angiotensin II	MESH:C068373	183	Chemical	Gene	START_ENTITY|appos|blocker blocker|amod|END_ENTITY	Safety and efficacy of eprosartan , a new angiotensin_II receptor blocker .
10467220	0	eprosartan	16,26	angiotensin_II	31,45	eprosartan	angiotensin II	MESH:C068373	24179(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Pharmacology of eprosartan , an angiotensin_II receptor antagonist : exploring hypotheses from clinical data .
10904023	0	eprosartan	36,46	angiotensin_II	10,24	eprosartan	angiotensin II	MESH:C068373	183	Chemical	Gene	antagonist|dobj|START_ENTITY antagonist|nsubj|Effect Effect|nmod|END_ENTITY	Effect of angiotensin_II antagonist eprosartan on hyperglycemia-induced activation of intrarenal renin-angiotensin system in healthy humans .
11383711	0	eprosartan	24,34	angiotensin_II	65,79	eprosartan	angiotensin II	MESH:C068373	24179(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|receptors receptors|compound|END_ENTITY	Differential effects of eprosartan and losartan at prejunctional angiotensin_II receptors .
11861115	0	eprosartan	55,65	angiotensin_II	81,95	eprosartan	angiotensin II	MESH:C068373	183	Chemical	Gene	elucidation|nmod|START_ENTITY peptide|nsubj|elucidation peptide|dobj|antagonist antagonist|amod|END_ENTITY	Structure elucidation and conformational properties of eprosartan , a non peptide angiotensin_II AT1 antagonist .
15991986	0	eprosartan	56,66	angiotensin_II	20,34	eprosartan	angiotensin II	MESH:C068373	183	Chemical	Gene	START_ENTITY|nmod|antagonist antagonist|amod|END_ENTITY	Pharmacology of the angiotensin_II receptor antagonist , eprosartan .
9260987	0	eprosartan	60,70	angiotensin_II	33,47	eprosartan	angiotensin II	MESH:C068373	183	Chemical	Gene	response|acl|START_ENTITY response|nmod|antagonist antagonist|amod|END_ENTITY	Renal hemodynamic response to an angiotensin_II antagonist , eprosartan , in healthy men .
9399334	0	eprosartan	77,87	angiotensin_II	180,194	eprosartan	angiotensin II	MESH:C068373	24179(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY outflow|nmod|antagonist Inhibition|nmod|outflow Inhibition|dep|relationship relationship|nmod|differences differences|nmod|blockade blockade|compound|END_ENTITY	Inhibition of sympathetic outflow by the angiotensin_II receptor antagonist , eprosartan , but not by losartan , valsartan or irbesartan : relationship to differences in prejunctional angiotensin_II receptor blockade .
9399334	0	eprosartan	77,87	angiotensin_II	41,55	eprosartan	angiotensin II	MESH:C068373	24179(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Inhibition of sympathetic outflow by the angiotensin_II receptor antagonist , eprosartan , but not by losartan , valsartan or irbesartan : relationship to differences in prejunctional angiotensin_II receptor blockade .
9533060	0	eprosartan	68,78	angiotensin_II	83,97	eprosartan	angiotensin II	MESH:C068373	183	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Effect of ranitidine on the pharmacokinetics of orally administered eprosartan , an angiotensin_II antagonist , in healthy male volunteers .
9585802	0	eprosartan	89,99	angiotensin_II	104,118	eprosartan	angiotensin II	MESH:C068373	183	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	A dose-response study to assess the renal hemodynamic , vascular , and hormonal effects of eprosartan , an angiotensin_II AT1-receptor antagonist , in sodium-replete healthy men .
8993244	0	epsilon-aminocaproic_acid	35,60	inducible_nitric_oxide_synthase	81,112	epsilon-aminocaproic acid	inducible nitric oxide synthase	MESH:D015119	18126(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Differing effects of aprotinin and epsilon-aminocaproic_acid on cytokine-induced inducible_nitric_oxide_synthase expression .
17161243	0	eptifibatide	39,51	tumor_necrosis_factor-alpha	55,82	eptifibatide	tumor necrosis factor-alpha	MESH:C086648	7124	Chemical	Gene	START_ENTITY|nmod|release release|amod|END_ENTITY	Effect of clopidogrel with and without eptifibatide on tumor_necrosis_factor-alpha and C-reactive_protein release after elective stenting : results from the CLEAR PLATELETS 1b study .
19297428	0	equol	49,54	CYP3A4	6,12	equol	CYP3A4	MESH:D060754	1576	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Human CYP3A4 and murine Cyp3A11 are regulated by equol and genistein via the pregnane_X_receptor in a species-specific manner .
16288994	0	equol	105,110	tumor_necrosis_factor-alpha	44,71	equol	tumor necrosis factor-alpha	MESH:D060754	21926(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Estrogen receptor-independent inhibition of tumor_necrosis_factor-alpha gene expression by phytoestrogen equol is mediated by blocking nuclear factor-kappaB activation in mouse macrophages .
17199797	0	ergocalciferol	10,24	parathyroid_hormone	50,69	ergocalciferol	parathyroid hormone	MESH:D004872	5741	Chemical	Gene	supplementation|amod|START_ENTITY supplementation|nmod|END_ENTITY	Effect of ergocalciferol supplementation on serum parathyroid_hormone and serum 25-hydroxyvitamin_D in chronic_kidney_disease .
42476	0	ergocristine	10,22	prolactin	26,35	ergocristine	prolactin	MESH:C100270	24683(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of ergocristine on prolactin secretion in the male rat with pituitaries grafted beneath the kidney capsule .
3653414	0	ergoline	18,26	prolactin	53,62	ergoline	prolactin	MESH:D004873	5617	Chemical	Gene	derivative|amod|START_ENTITY effect|nmod|derivative effect|nmod|secretion secretion|compound|END_ENTITY	The effect of the ergoline derivative , CU_32-085 , on prolactin secretion in hyperprolactinemic women .
6416848	0	ergoline	91,99	prolactin	41,50	ergoline	prolactin	MESH:D004873	24683(Tax:10116)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Correlation between inhibitory effect on prolactin secretion and antitumor activity of new ergoline compounds on DMBA-induced tumors in rats .
7191272	0	ergoline	51,59	prolactin	14,23	ergoline	prolactin	MESH:D004873	24683(Tax:10116)	Chemical	Gene	deprenon|amod|START_ENTITY rats|nmod|deprenon secretion|nmod|rats secretion|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of prolactin secretion in rats with the ergoline derivative deprenon .
18164304	0	ergometrine	63,74	oxytocin	47,55	ergometrine	oxytocin	MESH:D004874	5020	Chemical	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	A randomized comparative study of prophylactic oxytocin versus ergometrine in the third stage of labor .
940657	0	ergonovine	10,20	prolactin	24,33	ergonovine	prolactin	MESH:D004874	5617	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|amod|END_ENTITY	Effect of ergonovine on prolactin secretion and milk let-down .
11895447	0	ergosterol	24,34	Cdk1	54,58	ergosterol	Cdk1	MESH:D004875	983	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activation activation|amod|END_ENTITY	Differential effects of ergosterol and cholesterol on Cdk1 activation and SRE-driven transcription .
16125105	0	ergosterol	24,34	p450scc	49,56	ergosterol	p450scc	MESH:D004875	1583	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|nmod|END_ENTITY	Enzymatic metabolism of ergosterol by cytochrome p450scc to biologically active 17alpha,24-dihydroxyergosterol .
26994919	0	ergothioneine	57,70	OCTN1	51,56	ergothioneine	OCTN1	MESH:D004880	6580	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Wide tolerance to amino_acids substitutions in the OCTN1 ergothioneine transporter .
18670092	0	ergothioneine	31,44	Octn1	99,104	ergothioneine	Octn1	MESH:D004880	64037(Tax:10116)	Chemical	Gene	transport|amod|START_ENTITY characterization|nmod|transport characterization|nmod|END_ENTITY	Functional characterization of ergothioneine transport by rat organic cation/carnitine transporter Octn1 -LRB- slc22a4 -RRB- .
22100842	0	ergothioneine	20,33	SLC22A4	46,53	ergothioneine	SLC22A4	MESH:D004880	6583	Chemical	Gene	mRNA|amod|START_ENTITY mRNA|compound|END_ENTITY	Paramount levels of ergothioneine transporter SLC22A4 mRNA in boar seminal vesicles and cross-species analysis of ergothioneine and glutathione in seminal plasma .
18670092	0	ergothioneine	31,44	slc22a4	106,113	ergothioneine	slc22a4	MESH:D004880	64037(Tax:10116)	Chemical	Gene	transport|amod|START_ENTITY characterization|nmod|transport characterization|nmod|Octn1 Octn1|appos|END_ENTITY	Functional characterization of ergothioneine transport by rat organic cation/carnitine transporter Octn1 -LRB- slc22a4 -RRB- .
11518230	0	ergovaline	23,33	5-HT2A	39,45	ergovaline	5-HT2A	MESH:C076760	29595(Tax:10116)	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Complex interaction of ergovaline with 5-HT2A , 5-HT1B / 1D , and alpha1 receptors in isolated arteries of rat and guinea_pig .
12843651	0	eritadenine	19,30	Delta6-desaturase	55,72	eritadenine	Delta6-desaturase	MESH:C100029	83512(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Effects of dietary eritadenine on the liver microsomal Delta6-desaturase activity and its mRNA in rats .
12224653	0	eritadenine	19,30	delta6-desaturase	34,51	eritadenine	delta6-desaturase	MESH:C100029	83512(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effects of dietary eritadenine on delta6-desaturase activity and fatty_acid profiles of several lipids in rats fed different fats .
20216471	0	erlotinib	49,58	Apaf-1	85,91	erlotinib	Apaf-1	MESH:C400278	317	Chemical	Gene	START_ENTITY|nmod|modulation modulation|nmod|END_ENTITY	IL-24 gene transfer sensitizes melanoma cells to erlotinib through modulation of the Apaf-1 and Akt signaling pathways .
24637575	0	erlotinib	10,19	CYP3A	23,28	erlotinib	CYP3A	MESH:C400278	1576	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Effect of erlotinib on CYP3A activity , evaluated in vitro and by dual probes in patients with cancer .
17457047	0	erlotinib	92,101	EGFR	39,43	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	sensitivity|nmod|START_ENTITY influence|dobj|sensitivity influence|nsubj|expression expression|nmod|END_ENTITY	ErbB3 expression and dimerization with EGFR influence pancreatic_cancer cell sensitivity to erlotinib .
17699871	7	erlotinib	1063,1072	EGFR	1031,1035	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Phosphorylation of HER2 in HR cells was inhibited by the EGFR tyrosine kinase inhibitors erlotinib and gefitinib .
17898810	0	erlotinib	19,28	EGFR	80,84	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	therapy|amod|START_ENTITY response|nmod|therapy response|nmod|mutation mutation|amod|END_ENTITY	CNS response after erlotinib therapy in a patient with metastatic NSCLC with an EGFR mutation .
18520805	0	erlotinib	92,101	EGFR	185,189	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	sensitivity|amod|START_ENTITY predicts|dobj|sensitivity predicts|nmod|cells cells|acl|expressing expressing|dobj|gene gene|compound|END_ENTITY	Tumor dependence on the EGFR signaling pathway expressed by the p-EGFR :p - AKT ratio predicts erlotinib sensitivity in human non-small_cell_lung_cancer -LRB- NSCLC -RRB- cells expressing wild-type EGFR gene .
18520805	0	erlotinib	92,101	EGFR	24,28	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	sensitivity|amod|START_ENTITY predicts|dobj|sensitivity expressed|parataxis|predicts expressed|nsubj|dependence dependence|nmod|END_ENTITY	Tumor dependence on the EGFR signaling pathway expressed by the p-EGFR :p - AKT ratio predicts erlotinib sensitivity in human non-small_cell_lung_cancer -LRB- NSCLC -RRB- cells expressing wild-type EGFR gene .
19130057	0	erlotinib	147,156	EGFR	42,46	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	enhances|nmod|START_ENTITY enhances|nsubj|Activation Activation|nmod|stress stress|nmod|N-glycosylation N-glycosylation|compound|END_ENTITY	Activation of ER stress and inhibition of EGFR N-glycosylation by tunicamycin enhances susceptibility of human non-small cell lung_cancer cells to erlotinib .
19562712	0	erlotinib	42,51	EGFR	11,15	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	tyrosine|dobj|START_ENTITY tyrosine|nsubj|Effects Effects|nmod|END_ENTITY	Effects of EGFR tyrosine kinase inhibitor erlotinib in prostate_cancer cells in vitro .
19884861	0	erlotinib	74,83	EGFR	0,4	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	outcomes|nmod|START_ENTITY associated|nmod|outcomes associated|nsubjpass|mutations mutations|amod|END_ENTITY	EGFR mutations detected in plasma are associated with patient outcomes in erlotinib plus docetaxel-treated non-small_cell_lung_cancer .
19898258	0	erlotinib	20,29	EGFR	132,136	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	monotherapy|amod|START_ENTITY trial|nmod|monotherapy trial|acl:relcl|possess possess|dobj|mutations mutations|compound|END_ENTITY	A phase II trial of erlotinib monotherapy in pretreated patients with advanced non-small_cell_lung_cancer who do not possess active EGFR mutations : Okayama Lung_Cancer Study Group trial 0705 .
20595147	0	erlotinib	48,57	EGFR	77,81	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	responding|xcomp|START_ENTITY lung_cancer|acl|responding metastases|nmod|lung_cancer metastases|dep|importance importance|nmod|mutation mutation|amod|END_ENTITY	Brain metastases from lung_cancer responding to erlotinib : the importance of EGFR mutation .
20723376	2	erlotinib	322,331	EGFR	294,298	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	treated|nmod|START_ENTITY mutations|acl|treated mutations|amod|END_ENTITY	Clinical trials showed that patients with EGFR mutations treated with erlotinib has better clinical outcomes .
20878103	0	erlotinib	62,71	EGFR	133,137	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	START_ENTITY|nmod|mutation mutation|amod|END_ENTITY	Schedule-dependent antitumor activity of the combination with erlotinib and docetaxel in human non-small_cell_lung_cancer cells with EGFR mutation , KRAS mutation or both wild-type EGFR and KRAS .
21122380	0	erlotinib	103,112	EGFR	22,26	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	Relationship|acl|START_ENTITY Relationship|nmod|mutations mutations|compound|END_ENTITY	-LSB- Relationship between EGFR and K-ras mutations and clinicopathological characteristics and response to erlotinib treatment in 301 Chinese patients with non-small_cell_lung_cancer -RSB- .
21150674	0	erlotinib	44,53	EGFR	126,130	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	Impact|nmod|START_ENTITY Impact|nmod|resected_lung_adenocarcinomas resected_lung_adenocarcinomas|acl:relcl|harbor harbor|dobj|mutations mutations|amod|END_ENTITY	Impact on disease-free_survival of adjuvant erlotinib or gefitinib in patients with resected_lung_adenocarcinomas that harbor EGFR mutations .
21831955	0	erlotinib	110,119	EGFR	26,30	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	lung_cancer|nmod|START_ENTITY tyrosine|nmod|lung_cancer tyrosine|nsubj|sensitivity sensitivity|nmod|END_ENTITY	Maintained sensitivity to EGFR tyrosine kinase inhibitors in EGFR-mutant lung_cancer recurring after adjuvant erlotinib or gefitinib .
21865399	0	erlotinib	29,38	EGFR	63,67	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	high-dose|dobj|START_ENTITY high-dose|nmod|lung_cancer lung_cancer|compound|END_ENTITY	`` Pulsatile '' high-dose weekly erlotinib for CNS metastases from EGFR mutant non-small cell lung_cancer .
21914790	0	erlotinib	88,97	EGFR	69,73	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	protects|nmod|START_ENTITY protects|dobj|cells cells|nmod|inhibition inhibition|amod|END_ENTITY	The phosphatase inhibitor menadione -LRB- vitamin_K3 -RRB- protects cells from EGFR inhibition by erlotinib and cetuximab .
21941967	0	erlotinib	50,59	EGFR	64,68	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	A case of recurrent vulvar_carcinoma treated with erlotinib , an EGFR inhibitor .
21969500	0	erlotinib	102,111	EGFR	41,45	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	therapy|amod|START_ENTITY study|nmod|therapy analyses|nmod|study analyses|nmod|END_ENTITY	Prospective molecular marker analyses of EGFR and KRAS from a randomized , placebo-controlled study of erlotinib maintenance therapy in advanced non-small-cell_lung_cancer .
22075159	0	erlotinib	11,20	EGFR	35,39	erlotinib	EGFR	MESH:C400278	13649(Tax:10090)	Chemical	Gene	resistance|compound|START_ENTITY resistance|nmod|cells cells|amod|END_ENTITY	Overcoming erlotinib resistance in EGFR mutation-positive non-small_cell_lung_cancer cells by targeting survivin .
22173702	0	erlotinib	138,147	EGFR	67,71	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	retain|nmod|START_ENTITY retain|nsubj|lung_adenocarcinomas lung_adenocarcinomas|acl|treated treated|nmod|inhibitor inhibitor|compound|END_ENTITY	EGFR-mutant lung_adenocarcinomas treated first-line with the novel EGFR inhibitor , XL647 , can subsequently retain moderate sensitivity to erlotinib .
22278730	0	erlotinib	20,29	EGFR	47,51	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|wild-type wild-type|amod|END_ENTITY	A phase II trial of erlotinib in patients with EGFR wild-type advanced non-small-cell_lung_cancer .
22328842	0	erlotinib	24,33	EGFR	40,44	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	Response|nmod|START_ENTITY Response|nmod|patient patient|amod|END_ENTITY	Response to second-line erlotinib in an EGFR mutation-negative patient with non-small-cell_lung_cancer : make no assumptions .
22670114	0	erlotinib	12,21	EGFR	123,127	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	START_ENTITY|nmod|lung lung|nmod|mutation mutation|compound|END_ENTITY	Neoadjuvant erlotinib and surgical resection of a stage iiia papillary_adenocarcinoma of the lung with an L861Q activating EGFR mutation .
22726919	0	erlotinib	60,69	EGFR	39,43	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Monitoring reversible and irreversible EGFR inhibition with erlotinib and afatinib in a patient with EGFR-mutated non-small_cell_lung_cancer -LRB- NSCLC -RRB- using sequential -LSB- 18F -RSB- fluorothymidine -LRB- FLT - -RRB- PET .
22844075	0	erlotinib	94,103	EGFR	39,43	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	resistance|amod|START_ENTITY overcoming|dobj|resistance kinase|advcl|overcoming kinase|nsubj|therapy therapy|nmod|inhibitor inhibitor|compound|END_ENTITY	Combined therapy with mutant-selective EGFR inhibitor and Met kinase inhibitor for overcoming erlotinib resistance in EGFR-mutant lung_cancer .
22896669	0	erlotinib	12,21	EGFR	39,43	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|mutant mutant|compound|END_ENTITY	Response to erlotinib in patients with EGFR mutant advanced non-small_cell_lung_cancers with a squamous_or_squamous-like_component .
22980218	0	erlotinib	15,24	EGFR	77,81	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	derivatives|amod|START_ENTITY Development|nmod|derivatives Development|nmod|agents agents|nmod|activity activity|amod|END_ENTITY	Development of erlotinib derivatives as CIP2A-ablating agents independent of EGFR activity .
22982650	0	erlotinib	169,178	EGFR	21,25	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|Impact Impact|nmod|END_ENTITY	Impact of systematic EGFR and KRAS mutation evaluation on progression-free survival and overall_survival in patients with advanced non-small-cell_lung_cancer treated by erlotinib in a French prospective cohort -LRB- ERMETIC project -- part 2 -RRB- .
22983065	0	erlotinib	17,26	EGFR	104,108	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	START_ENTITY|nmod|therapy therapy|nmod|patients patients|nmod|epidermal_growth_factor_receptor epidermal_growth_factor_receptor|appos|END_ENTITY	Effectiveness of erlotinib as a second line therapy for patients with epidermal_growth_factor_receptor -LRB- EGFR -RRB- mutation in non-small_cell_lung_cancer -LRB- NSCLC -RRB- : our clinical experience .
23028234	0	erlotinib	12,21	EGFR	83,87	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	START_ENTITY|dep|cost-effectiveness cost-effectiveness|nmod|wild-type wild-type|amod|END_ENTITY	Maintenance erlotinib in advanced nonsmall_cell_lung_cancer : cost-effectiveness in EGFR wild-type across Europe .
23291074	0	erlotinib	13,22	EGFR	125,129	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	Efficacy|nmod|START_ENTITY Efficacy|nmod|patients patients|nmod|metastasis metastasis|nmod|non-small_cell_lung_cancer non-small_cell_lung_cancer|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Efficacy of erlotinib after the failure of gefitinib in patients with metastasis of non-small_cell_lung_cancer with unknown EGFR mutation status -RSB- .
23306923	0	erlotinib	22,31	EGFR	121,125	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	START_ENTITY|nmod|hepatotoxicity hepatotoxicity|nmod|patient patient|nmod|mutations mutations|compound|END_ENTITY	-LSB- Efficacy of low-dose erlotinib against gefitinib-induced hepatotoxicity in a patient with lung_adenocarcinoma harboring EGFR mutations -RSB- .
23371860	0	erlotinib	58,67	EGFR	86,90	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	profiling|dobj|START_ENTITY profiling|nmod|lines lines|amod|gefitinib gefitinib|nmod|END_ENTITY	Quantitative chemical proteomics profiling differentiates erlotinib from gefitinib in EGFR wild-type non-small_cell_lung_carcinoma cell lines .
23456778	0	erlotinib	114,123	EGFR	170,174	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	study|nmod|START_ENTITY OPTIMAL|appos|study analyses|nmod|OPTIMAL analyses|nmod|non-small-cell_lung_cancer non-small-cell_lung_cancer|amod|END_ENTITY	Quality of life -LRB- QoL -RRB- analyses from OPTIMAL -LRB- CTONG-0802 -RRB- , a phase III , randomised , open-label study of first-line erlotinib versus chemotherapy in patients with advanced EGFR mutation-positive non-small-cell_lung_cancer -LRB- NSCLC -RRB- .
23507602	0	erlotinib	87,96	EGFR	63,67	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	effective|nsubj|START_ENTITY coexisting|advcl|effective coexisting|dobj|mutations mutations|compound|END_ENTITY	-LSB- A case of lung_adenocarcinoma with coexisting G719X and T790M EGFR mutations in which erlotinib was effective for the treatment of leptomeningeal_carcinomatosis -RSB- .
23575415	0	erlotinib	122,131	EGFR	81,85	erlotinib	EGFR	MESH:C400278	13649(Tax:10090)	Chemical	Gene	cells|nmod|START_ENTITY cells|amod|END_ENTITY	The autophagy inhibitor chloroquine overcomes the innate resistance of wild-type EGFR non-small-cell_lung_cancer cells to erlotinib .
23599349	0	erlotinib	18,27	EGFR	111,115	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|mutations mutations|compound|END_ENTITY	Phase II trial of erlotinib for Japanese patients with previously treated non-small-cell_lung_cancer harboring EGFR mutations : results of Lung Oncology Group in Kyushu -LRB- LOGiK0803 -RRB- .
23638043	0	erlotinib	15,24	EGFR	0,4	erlotinib	EGFR	MESH:C400278	13649(Tax:10090)	Chemical	Gene	delays|compound|START_ENTITY delays|amod|END_ENTITY	EGFR inhibitor erlotinib delays disease progression but does not extend survival in the SOD1 mouse model of ALS .
23733083	4	erlotinib	714,723	EGFR	511,515	erlotinib	EML4	MESH:C400278	27436	Chemical	Gene	crizotinib|dep|START_ENTITY inhibitors|appos|crizotinib markers|nsubj|inhibitors markers|dep|important important|nsubj|CONCLUSION CONCLUSION|dep|mutations mutations|amod|END_ENTITY	CONCLUSION : EGFR activating mutations -LRB- exons 18 to 21 -RRB- and EML4-ALK rearrangement are clinically important markers able to select NSCLC patients which benefit from EGFR or ALK tyrosine kinase inhibitors -LRB- gefitinib , erlotinib , crizotinib -RRB- .
23783797	0	erlotinib	60,69	EGFR	123,127	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	treatment|compound|START_ENTITY factors|nmod|treatment factors|nmod|gene gene|amod|END_ENTITY	Predictive and prognostic factors in second - and third-line erlotinib treatment in NSCLC patients with known status of the EGFR gene .
23800712	4	erlotinib	829,838	EGFR	787,791	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	treated|amod|START_ENTITY treated|nmod|regimen regimen|amod|END_ENTITY	METHODS : We reviewed the electronic records of patients with NSCLC treated with an EGFR inhibitor-based combination regimen : erlotinib and cetuximab ; erlotinib , cetuximab and bevacizumab ; erlotinib and dasatinib ; erlotinib and bortezomib ; or cetuximab and sirolimus .
23800712	4	erlotinib	854,863	EGFR	787,791	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	treated|dep|START_ENTITY treated|nmod|regimen regimen|amod|END_ENTITY	METHODS : We reviewed the electronic records of patients with NSCLC treated with an EGFR inhibitor-based combination regimen : erlotinib and cetuximab ; erlotinib , cetuximab and bevacizumab ; erlotinib and dasatinib ; erlotinib and bortezomib ; or cetuximab and sirolimus .
23800712	4	erlotinib	892,901	EGFR	787,791	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	patients|amod|START_ENTITY patients|nmod|treated treated|nmod|regimen regimen|amod|END_ENTITY	METHODS : We reviewed the electronic records of patients with NSCLC treated with an EGFR inhibitor-based combination regimen : erlotinib and cetuximab ; erlotinib , cetuximab and bevacizumab ; erlotinib and dasatinib ; erlotinib and bortezomib ; or cetuximab and sirolimus .
23803112	0	erlotinib	73,82	EGFR	135,139	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	START_ENTITY|nmod|status status|amod|END_ENTITY	Clinical outcomes and prognostic factors associated with the response to erlotinib in non-small-cell_lung_cancer patients with unknown EGFR mutational status .
23898110	0	erlotinib	136,145	EGFR	79,83	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	followed|nmod|START_ENTITY pemetrexed|acl|followed treatment|dep|pemetrexed treatment|nmod|gene gene|compound|END_ENTITY	Sequential treatment of advanced-stage_lung_adenocarcinoma harboring wild-type EGFR gene : second-line pemetrexed followed by third-line erlotinib versus the reverse sequence .
23910906	0	erlotinib	66,75	EGFR	136,140	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	A prospective , phase II , open-label study -LRB- JO22903 -RRB- of first-line erlotinib in Japanese patients with epidermal_growth_factor_receptor -LRB- EGFR -RRB- mutation-positive advanced non-small-cell_lung_cancer -LRB- NSCLC -RRB- .
23969006	0	erlotinib	56,65	EGFR	0,4	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	exon|nmod|START_ENTITY exon|nsubj|END_ENTITY	EGFR exon 20 insertion A763-Y764insFQEA and response to erlotinib -- Letter .
23986053	0	erlotinib	95,104	EGFR	66,70	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	having|advcl|START_ENTITY END_ENTITY|acl|having	-LSB- A case of lung_adenocarcinoma wtih exon19 and T790M mutations in EGFR having good response to erlotinib after gefitinib treatment failure -RSB- .
24019973	3	erlotinib	354,363	EGFR	346,350	erlotinib	Bcl2	MESH:C400278	596	Chemical	Gene	found|nmod|START_ENTITY found|dobj|inhibition inhibition|nmod|END_ENTITY	Here , we found that inhibition of EGFR by erlotinib stimulated phosphorylation and activation of STAT3 leading to increased Bcl2/Bcl-XL expression in head_and_neck_cancer cells , which may dampen the therapeutic efficacy of erlotinib against head_and_neck_cancer .
24019973	3	erlotinib	535,544	EGFR	346,350	erlotinib	Bcl2	MESH:C400278	596	Chemical	Gene	efficacy|nmod|START_ENTITY dampen|dobj|efficacy cells|acl:relcl|dampen expression|nmod|cells leading|nmod|expression STAT3|acl|leading phosphorylation|nmod|STAT3 stimulated|dobj|phosphorylation erlotinib|acl|stimulated found|nmod|erlotinib found|dobj|inhibition inhibition|nmod|END_ENTITY	Here , we found that inhibition of EGFR by erlotinib stimulated phosphorylation and activation of STAT3 leading to increased Bcl2/Bcl-XL expression in head_and_neck_cancer cells , which may dampen the therapeutic efficacy of erlotinib against head_and_neck_cancer .
24220936	0	erlotinib	69,78	EGFR	109,113	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	START_ENTITY|nmod|patients patients|compound|END_ENTITY	Phase I dose-escalation study of oral vinflunine in combination with erlotinib in pre-treated and unselected EGFR patients with locally advanced or metastatic non-small-cell_lung_cancer .
24222153	0	erlotinib	25,34	EGFR	103,107	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	monotherapy|amod|START_ENTITY significance|nmod|monotherapy significance|nmod|mutations mutations|amod|END_ENTITY	Clinical significance of erlotinib monotherapy for gefitinib-resistant non-small_cell_lung_cancer with EGFR mutations .
24279293	0	erlotinib	16,25	EGFR	0,4	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	blistering|amod|START_ENTITY inhibitors|dobj|blistering inhibitors|nsubj|END_ENTITY	EGFR inhibitors erlotinib and lapatinib ameliorate epidermal blistering in pemphigus_vulgaris in a non-linear , V-shaped relationship .
24388704	0	erlotinib	45,54	EGFR	0,4	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	frequency|nmod|START_ENTITY frequency|amod|END_ENTITY	EGFR mutation frequency and effectiveness of erlotinib : a prospective observational study in Danish patients with non-small_cell_lung_cancer .
24425324	0	erlotinib	113,122	EGFR	16,20	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	treated|nmod|START_ENTITY patients|acl|treated response|nmod|patients predicts|dobj|response predicts|nsubj|presence presence|nmod|mutations mutations|amod|END_ENTITY	The presence of EGFR mutations predicts the response in Chinese non-small_cell_lung_cancer patients treated with erlotinib .
24478319	0	erlotinib	17,26	EGFR	71,75	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	response|acl|START_ENTITY response|acl|containing containing|dobj|mutations mutations|compound|END_ENTITY	Poor response to erlotinib in patients with tumors containing baseline EGFR T790M mutations found by routine clinical molecular testing .
24481719	0	erlotinib	30,39	EGFR	124,128	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	START_ENTITY|nmod|wild-type wild-type|amod|pemetrexed pemetrexed|nmod|therapy therapy|nmod|treatment treatment|nmod|patients patients|nmod|END_ENTITY	A randomized phase 2 trial of erlotinib versus pemetrexed as second-line therapy in the treatment of patients with advanced EGFR wild-type and EGFR FISH-positive lung_adenocarcinoma .
24493829	0	erlotinib	118,127	EGFR	14,18	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	treated|nmod|START_ENTITY impact|acl|treated impact|nmod|mutations mutations|compound|END_ENTITY	The impact of EGFR T790M mutations and BIM mRNA expression on outcome in patients with EGFR-mutant NSCLC treated with erlotinib or chemotherapy in the randomized phase III EURTAC trial .
24533047	0	erlotinib	25,34	EGFR	132,136	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	meta-analysis|advcl|START_ENTITY meta-analysis|advcl|harboring harboring|dobj|mutations mutations|amod|END_ENTITY	Network meta-analysis of erlotinib , gefitinib , afatinib and icotinib in patients with advanced non-small-cell_lung_cancer harboring EGFR mutations .
24636848	0	erlotinib	161,170	EGFR	139,143	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	progression|amod|START_ENTITY I/II|nmod|progression I/II|dobj|trial trial|nmod|mutations mutations|appos|END_ENTITY	Phase I/II trial of vorinostat -LRB- SAHA -RRB- and erlotinib for non-small_cell_lung_cancer -LRB- NSCLC -RRB- patients with epidermal_growth_factor_receptor -LRB- EGFR -RRB- mutations after erlotinib progression .
24908064	0	erlotinib	64,73	EGFR	37,41	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	showed|nmod|START_ENTITY showed|nsubj|mutation mutation|nmod|exon exon|nmod|END_ENTITY	A novel point mutation in exon 20 of EGFR showed sensitivity to erlotinib .
25017413	0	erlotinib	107,116	EGFR	0,4	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	treated|nmod|START_ENTITY patients|acl|treated predict|nmod|patients predict|nsubj|polymorphism polymorphism|compound|END_ENTITY	EGFR CA repeat polymorphism predict clinical outcome in EGFR mutation positive NSCLC patients treated with erlotinib .
25017413	0	erlotinib	107,116	EGFR	56,60	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	treated|nmod|START_ENTITY patients|acl|treated patients|amod|END_ENTITY	EGFR CA repeat polymorphism predict clinical outcome in EGFR mutation positive NSCLC patients treated with erlotinib .
25056302	0	erlotinib	29,38	EGFR	56,60	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	doses|nmod|START_ENTITY doses|nmod|patients patients|nmod|mutation mutation|amod|END_ENTITY	Effective ultra-low doses of erlotinib in patients with EGFR sensitising mutation .
25076254	0	erlotinib	17,26	EGFR	72,76	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	START_ENTITY|nmod|patient patient|nmod|mutation mutation|compound|END_ENTITY	Retreatment with erlotinib of a patient with metastatic NSCLC harboring EGFR mutation : a case report .
25215536	0	erlotinib	61,70	EGFR	10,14	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	Impact|nmod|START_ENTITY Impact|nmod|methods methods|amod|END_ENTITY	Impact of EGFR mutation detection methods on the efficacy of erlotinib in patients with advanced EGFR-wild type lung_adenocarcinoma .
25249428	0	erlotinib	20,29	EGFR	166,170	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	monotherapy|amod|START_ENTITY study|nmod|monotherapy study|dep|Re-evaluation Re-evaluation|nmod|status status|amod|END_ENTITY	A phase II study of erlotinib monotherapy in pre-treated non-small_cell_lung_cancer without EGFR gene mutation who have never/light smoking history : Re-evaluation of EGFR gene status -LRB- NEJ006/TCOG0903 -RRB- .
25249428	0	erlotinib	20,29	EGFR	92,96	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	monotherapy|amod|START_ENTITY monotherapy|nmod|non-small_cell_lung_cancer non-small_cell_lung_cancer|nmod|mutation mutation|amod|END_ENTITY	A phase II study of erlotinib monotherapy in pre-treated non-small_cell_lung_cancer without EGFR gene mutation who have never/light smoking history : Re-evaluation of EGFR gene status -LRB- NEJ006/TCOG0903 -RRB- .
25249545	0	erlotinib	172,181	EGFR	50,54	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	responsiveness|nmod|START_ENTITY lung_tumors|appos|responsiveness causes|nmod|lung_tumors causes|dobj|over-expression over-expression|compound|END_ENTITY	Neurotensin -LRB- NTS -RRB- and its receptor -LRB- NTSR1 -RRB- causes EGFR , HER2 and HER3 over-expression and their autocrine/paracrine activation in lung_tumors , confirming responsiveness to erlotinib .
25279187	0	erlotinib	18,27	EGFR	118,122	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	study|nmod|START_ENTITY treated|nsubj|study treated|nmod|reevaluation reevaluation|amod|END_ENTITY	Phase II study of erlotinib for previously treated patients with EGFR wild-type non-small-cell_lung_cancer , following EGFR mutation status reevaluation with the Scorpion Amplified Refractory Mutation System .
25279187	0	erlotinib	18,27	EGFR	65,69	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	study|nmod|START_ENTITY treated|nsubj|study treated|nmod|non-small-cell_lung_cancer non-small-cell_lung_cancer|amod|END_ENTITY	Phase II study of erlotinib for previously treated patients with EGFR wild-type non-small-cell_lung_cancer , following EGFR mutation status reevaluation with the Scorpion Amplified Refractory Mutation System .
25279299	0	erlotinib	93,102	EGFR	74,78	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	responsive|xcomp|START_ENTITY END_ENTITY|amod|responsive	Getting out of a wheelchair : an uncommon insertion mutation in exon 19 of EGFR responsive to erlotinib .
25364452	0	erlotinib	99,108	EGFR	36,40	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|factors factors|nmod|patients patients|nmod|non-small_cell_lung_cancer non-small_cell_lung_cancer|amod|END_ENTITY	Predictive factors in patients with EGFR mutation-negative non-small_cell_lung_cancer treated with erlotinib .
25413624	0	erlotinib	84,93	EGFR	128,132	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	CUL4A overexpression enhances lung_tumor growth and sensitizes_lung_cancer cells to erlotinib via transcriptional regulation of EGFR .
25442261	9	erlotinib	1334,1343	EGFR	1283,1287	erlotinib	MEK2	MESH:C400278	5605	Chemical	Gene	bound|nmod|START_ENTITY bound|nmod|END_ENTITY	Honokiol bound with comparable binding energies to EGFR -LRB- -7.30 0.01 kcal/mol -RRB- as the control drugs erlotinib -LRB- -7.50 0.30 kcal/mol -RRB- and gefitinib -LRB- -8.30 0.10 kcal/mol -RRB- .
25521405	0	erlotinib	91,100	EGFR	35,39	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	sensitive|xcomp|START_ENTITY sensitive|nsubj|adenocarcinomas adenocarcinomas|compound|END_ENTITY	Clinical and in vivo evidence that EGFR S768I mutant lung adenocarcinomas are sensitive to erlotinib .
25806184	0	erlotinib	11,20	EGFR	56,60	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	selected|nsubj|START_ENTITY selected|nmod|mutation mutation|amod|END_ENTITY	First line erlotinib for NSCLC patients not selected by EGFR mutation : keep carrying the TORCH or time to let the flame die ?
25897987	7	erlotinib	847,856	EGFR	830,834	erlotinib	ZEB1	MESH:C400278	6935	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	EGFR inhibitors , erlotinib and cetuximab , significantly suppressed enrichment of CSCs via TGF-b1-mediated EMT .
25897987	7	erlotinib	847,856	EGFR	830,834	erlotinib	ZEB1	MESH:C400278	6935	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	EGFR inhibitors , erlotinib and cetuximab , significantly suppressed enrichment of CSCs via TGF-b1-mediated EMT .
26043909	0	erlotinib	20,29	EGFR	88,92	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	monotherapy|amod|START_ENTITY trial|nmod|monotherapy trial|nmod|non-small_cell_lung_cancer non-small_cell_lung_cancer|amod|END_ENTITY	A phase II trial of erlotinib monotherapy for pretreated elderly patients with advanced EGFR wild-type non-small_cell_lung_cancer .
26105600	0	erlotinib	11,20	EGFR	76,80	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	START_ENTITY|nmod|gemcitabine/cisplatin gemcitabine/cisplatin|nmod|patients patients|nmod|non-small-cell_lung_cancer non-small-cell_lung_cancer|amod|END_ENTITY	First-line erlotinib versus gemcitabine/cisplatin in patients with advanced EGFR mutation-positive non-small-cell_lung_cancer : analyses from the phase III , randomized , open-label , ENSURE study .
26105600	0	erlotinib	11,20	EGFR	76,80	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	START_ENTITY|nmod|gemcitabine/cisplatin gemcitabine/cisplatin|nmod|patients patients|nmod|non-small-cell_lung_cancer non-small-cell_lung_cancer|amod|END_ENTITY	First-line erlotinib versus gemcitabine/cisplatin in patients with advanced EGFR mutation-positive non-small-cell_lung_cancer : analyses from the phase III , randomized , open-label , ENSURE study .
26174465	0	erlotinib	54,63	EGFR	108,112	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|mutations mutations|amod|END_ENTITY	A prospective , multicentre phase II trial of low-dose erlotinib in non-small cell lung cancer patients with EGFR mutations pretreated with chemotherapy : Thoracic Oncology Research Group 0911 .
26458306	0	erlotinib	40,49	EGFR	120,124	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	therapy|amod|START_ENTITY significance|nmod|therapy pemetrexed|nsubj|significance pemetrexed|nmod|END_ENTITY	Clinical and biological significance of erlotinib therapy after pemetrexed in non-small_cell_lung_cancer with wild-type EGFR .
26757927	0	erlotinib	63,72	EGFR	86,90	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Evodiamine induces apoptosis and enhances apoptotic effects of erlotinib in wild-type EGFR NSCLC cells via S6K1-mediated Mcl-1 inhibition .
26820683	1	erlotinib	30,39	EGFR	118,122	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	ratio|amod|START_ENTITY role|nmod|ratio role|nmod|skin_rash skin_rash|amod|END_ENTITY	- The role of erlotinib metabolic ratio from patient serum in the search of predictive biomarkers for EGFR inhibitor-mediated skin_rash .
26857779	0	erlotinib	11,20	EGFR	59,63	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	therapy|amod|START_ENTITY Effects|nmod|therapy -RSB-|nsubj|Effects -RSB-|nmod|mutated mutated|compound|END_ENTITY	Effects of erlotinib therapy on -LSB- -LRB- 11 -RRB- C -RSB- erlotinib uptake in EGFR mutated , advanced NSCLC .
26883194	0	erlotinib	121,130	EGFR	164,168	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	START_ENTITY|nmod|cells cells|acl|harboring harboring|dobj|mutation mutation|compound|END_ENTITY	Integrated genomic approaches identify upregulation of SCRN1 as a novel mechanism associated with acquired resistance to erlotinib in PC9 cells harboring oncogenic EGFR mutation .
26917973	0	erlotinib	39,48	EGFR	120,124	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	treatment|amod|START_ENTITY reduced|nmod|treatment reduced|nmod|mutation mutation|compound|END_ENTITY	Risk of brain metastasis reduced after erlotinib treatment in advanced pulmonary_adenocarcinoma patients with sensitive EGFR mutation .
26973211	0	erlotinib	99,108	EGFR	56,60	erlotinib	EGFR	MESH:C400278	1956	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|burden burden|nmod|marker marker|nmod|outcome outcome|nmod|patients patients|compound|END_ENTITY	Metabolic_tumor burden as marker of outcome in advanced EGFR wild-type NSCLC patients treated with erlotinib .
24512728	0	erlotinib	16,25	EGF_receptor	89,101	erlotinib	EGF receptor	MESH:C400278	1956	Chemical	Gene	resistance|amod|START_ENTITY lowers|dobj|resistance lowers|nmod|cells cells|nmod|END_ENTITY	Curcumin lowers erlotinib resistance in non-small_cell_lung_carcinoma cells with mutated EGF_receptor .
25390346	0	erlotinib	49,58	Epidermal_growth_factor_receptor	0,32	erlotinib	Epidermal growth factor receptor	MESH:C400278	24329(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Epidermal_growth_factor_receptor inhibition with erlotinib partially prevents cisplatin-induced nephrotoxicity in rats .
25791345	0	erlotinib	47,56	Epidermal_growth_factor_receptor	0,32	erlotinib	Epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Epidermal_growth_factor_receptor inhibition by erlotinib prevents vascular smooth muscle cell and monocyte-macrophage function in vitro .
26096453	0	erlotinib	120,129	Epidermal_growth_factor_receptor	0,32	erlotinib	Epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	exon|advcl|START_ENTITY exon|nsubj|END_ENTITY	Epidermal_growth_factor_receptor exon 20 insertions in advanced_lung_adenocarcinomas : Clinical outcomes and response to erlotinib .
26137049	0	erlotinib	126,135	Epidermal_growth_factor_receptor	0,32	erlotinib	Epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	treated|nmod|START_ENTITY sarcomatoid_carcinoma|acl|treated analysis|nmod|sarcomatoid_carcinoma analysis|compound|END_ENTITY	Epidermal_growth_factor_receptor mutation heterogeneity analysis of pulmonary sarcomatoid_carcinoma successfully treated with erlotinib : A case report .
26423803	0	erlotinib	49,58	Epidermal_growth_factor_receptor	0,32	erlotinib	Epidermal growth factor receptor	MESH:C400278	24329(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Epidermal_growth_factor_receptor inhibition with erlotinib ameliorates anti-Thy 1.1-induced experimental glomerulonephritis .
21385921	0	erlotinib	27,36	KRAS	59,63	erlotinib	KRAS	MESH:C400278	3845	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|nmod|END_ENTITY	Synergistic effect between erlotinib and MEK inhibitors in KRAS wild-type human pancreatic_cancer cells .
19884559	0	erlotinib	18,27	S0317	120,125	erlotinib	S0317	MESH:C400278	1076747(Tax:198215)	Chemical	Gene	study|nmod|START_ENTITY study|dep|END_ENTITY	Phase II study of erlotinib in patients with locally advanced or metastatic papillary histology renal_cell_cancer : SWOG S0317 .
18758306	0	erlotinib	51,60	S0341	41,46	erlotinib	S0341	MESH:C400278	1076774(Tax:198215)	Chemical	Gene	trial|nmod|START_ENTITY trial|appos|END_ENTITY	Southwest Oncology Group phase II trial -LRB- S0341 -RRB- of erlotinib -LRB- OSI-774 -RRB- in patients with advanced non-small_cell_lung_cancer and a performance status of 2 .
23894143	0	erlotinib	45,54	STAT3	78,83	erlotinib	STAT3	MESH:C400278	6774	Chemical	Gene	START_ENTITY|nmod|suppression suppression|nmod|END_ENTITY	Niclosamide overcomes acquired resistance to erlotinib through suppression of STAT3 in non-small cell lung_cancer .
24114668	0	erlotinib	31,40	amphiregulin	161,173	erlotinib	amphiregulin	MESH:C400278	374	Chemical	Gene	Intermittent|nmod|START_ENTITY Intermittent|dep|correlation correlation|nmod|END_ENTITY	Intermittent versus continuous erlotinib with concomitant modified `` XELOX '' -LRB- q3W -RRB- in first-line treatment of metastatic colorectal_cancer : correlation with serum amphiregulin and transforming_growth_factor_alpha .
27004400	0	erlotinib	83,92	amphiregulin	123,135	erlotinib	amphiregulin	MESH:C400278	374	Chemical	Gene	START_ENTITY|nmod|secretion secretion|nmod|END_ENTITY	MAPK1E322K mutation increases head_and_neck_squamous_cell_carcinoma sensitivity to erlotinib through enhanced secretion of amphiregulin .
15284258	0	erlotinib	118,127	epidermal_growth_factor_receptor	132,164	erlotinib	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	Evaluation|nmod|START_ENTITY tyrosine|advcl|Evaluation tyrosine|nsubj|END_ENTITY	Evaluation of biologic end points and pharmacokinetics in patients with metastatic breast_cancer after treatment with erlotinib , an epidermal_growth_factor_receptor tyrosine kinase inhibitor .
15638953	0	erlotinib	97,106	epidermal_growth_factor_receptor	38,70	erlotinib	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	tyrosine|dobj|START_ENTITY tyrosine|nsubj|data data|nmod|END_ENTITY	Phase II clinical trial data with the epidermal_growth_factor_receptor tyrosine kinase inhibitor erlotinib -LRB- OSI-774 -RRB- in non-small-cell_lung_cancer .
15753462	0	erlotinib	193,202	epidermal_growth_factor_receptor	134,166	erlotinib	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	inhibitor|dep|START_ENTITY inhibitor|compound|END_ENTITY	Phase I/II trial evaluating the anti-vascular_endothelial_growth_factor monoclonal antibody bevacizumab in combination with the HER-1 / epidermal_growth_factor_receptor tyrosine kinase inhibitor erlotinib for patients with recurrent non-small-cell_lung_cancer .
15833866	0	erlotinib	109,118	epidermal_growth_factor_receptor	52,84	erlotinib	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|xcomp|signaling	Mechanisms of enhanced radiation response following epidermal_growth_factor_receptor signaling inhibition by erlotinib -LRB- Tarceva -RRB- .
16043828	0	erlotinib	203,212	epidermal_growth_factor_receptor	17,49	erlotinib	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	treated|nmod|START_ENTITY non-small-cell_lung_cancer|acl|treated patients|nmod|non-small-cell_lung_cancer indicators|nmod|patients indicators|nsubj|Mutations Mutations|nmod|END_ENTITY	Mutations in the epidermal_growth_factor_receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell_lung_cancer treated with chemotherapy alone and in combination with erlotinib .
16177282	0	erlotinib	101,110	epidermal_growth_factor_receptor	57,89	erlotinib	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	inhibitors|dobj|START_ENTITY inhibitors|nsubj|knowledge knowledge|nmod|END_ENTITY	Current knowledge and future directions of the selective epidermal_growth_factor_receptor inhibitors erlotinib -LRB- Tarceva -RRB- and gefitinib -LRB- Iressa -RRB- .
16217753	0	erlotinib	50,59	epidermal_growth_factor_receptor	14,46	erlotinib	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	Targeting|nmod|START_ENTITY Targeting|dobj|END_ENTITY	Targeting the epidermal_growth_factor_receptor by erlotinib -LRB- Tarceva -RRB- for the treatment of esophageal_cancer .
16912195	0	erlotinib	172,181	epidermal_growth_factor_receptor	112,144	erlotinib	epidermal growth factor receptor	MESH:C400278	13649(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Kinetic analysis of epidermal_growth_factor_receptor somatic mutant proteins shows increased sensitivity to the epidermal_growth_factor_receptor tyrosine kinase inhibitor , erlotinib .
16912195	0	erlotinib	172,181	epidermal_growth_factor_receptor	20,52	erlotinib	epidermal growth factor receptor	MESH:C400278	13649(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY shows|nmod|inhibitor shows|nsubj|analysis analysis|nmod|proteins proteins|amod|END_ENTITY	Kinetic analysis of epidermal_growth_factor_receptor somatic mutant proteins shows increased sensitivity to the epidermal_growth_factor_receptor tyrosine kinase inhibitor , erlotinib .
16937526	0	erlotinib	85,94	epidermal_growth_factor_receptor	49,81	erlotinib	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	involved|nmod|START_ENTITY involved|nmod|inhibition inhibition|nmod|END_ENTITY	Signaling pathways involved in the inhibition of epidermal_growth_factor_receptor by erlotinib in hepatocellular_cancer .
17409968	0	erlotinib	147,156	epidermal_growth_factor_receptor	20,52	erlotinib	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	advanced|nmod|START_ENTITY advanced|nsubj|utility utility|nmod|expression expression|compound|END_ENTITY	Clinical utility of epidermal_growth_factor_receptor expression for selecting patients with advanced non-small_cell_lung_cancer for treatment with erlotinib .
17878175	0	erlotinib	81,90	epidermal_growth_factor_receptor	15,47	erlotinib	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	treatment|amod|START_ENTITY pathway|nmod|treatment pathway|nsubj|Markers Markers|nmod|END_ENTITY	Markers in the epidermal_growth_factor_receptor pathway and skin_toxicity during erlotinib treatment .
18187583	0	erlotinib	63,72	epidermal_growth_factor_receptor	77,109	erlotinib	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Molecular mechanisms underlying the synergistic interaction of erlotinib , an epidermal_growth_factor_receptor tyrosine kinase inhibitor , with the multitargeted antifolate pemetrexed in non-small-cell_lung_cancer cells .
19260752	0	erlotinib	132,141	epidermal_growth_factor_receptor	81,113	erlotinib	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	inhibitors|xcomp|START_ENTITY inhibitors|nsubj|features features|acl|adenocarcinoma_of_the_lung adenocarcinoma_of_the_lung|nmod|kinase kinase|compound|END_ENTITY	Morphologic features of adenocarcinoma_of_the_lung predictive of response to the epidermal_growth_factor_receptor kinase inhibitors erlotinib and gefitinib .
20088749	0	erlotinib	12,21	epidermal_growth_factor_receptor	42,74	erlotinib	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	review|nmod|START_ENTITY review|dep|END_ENTITY	A review of erlotinib -- an oral , selective epidermal_growth_factor_receptor tyrosine kinase inhibitor .
20961434	0	erlotinib	43,52	epidermal_growth_factor_receptor	103,135	erlotinib	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	gemcitabine|amod|START_ENTITY gallbladder_cancer|nmod|gemcitabine response|nmod|gallbladder_cancer require|nsubj|response require|dobj|mutation mutation|nmod|gene gene|compound|END_ENTITY	Complete response in gallbladder_cancer to erlotinib plus gemcitabine does not require mutation of the epidermal_growth_factor_receptor gene : a case report .
21550561	0	erlotinib	96,105	epidermal_growth_factor_receptor	220,252	erlotinib	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	START_ENTITY|nmod|docetaxel docetaxel|nmod|treatment treatment|nmod|patients patients|acl|affected affected|nmod|absence absence|nmod|mutations mutations|compound|END_ENTITY	Rationale for treatment and study design of tailor : a randomized phase III trial of second-line erlotinib versus docetaxel in the treatment of patients affected by advanced non-small-cell_lung_cancer with the absence of epidermal_growth_factor_receptor mutations .
21623279	0	erlotinib	148,157	epidermal_growth_factor_receptor	88,120	erlotinib	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	inhibitors|xcomp|START_ENTITY inhibitors|nsubj|trial trial|nmod|dasatinib dasatinib|nmod|patients patients|nmod|resistance resistance|nmod|treatment treatment|nmod|kinase kinase|compound|END_ENTITY	Phase II trial of dasatinib for patients with acquired resistance to treatment with the epidermal_growth_factor_receptor tyrosine kinase inhibitors erlotinib or gefitinib .
21681573	0	erlotinib	27,36	epidermal_growth_factor_receptor	119,151	erlotinib	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	Efficacy|nmod|START_ENTITY Efficacy|nmod|mutation mutation|compound|END_ENTITY	Efficacy of increased-dose erlotinib for central_nervous_system_metastases in non-small_cell_lung_cancer patients with epidermal_growth_factor_receptor mutation .
21715361	0	erlotinib	18,27	epidermal_growth_factor_receptor	115,147	erlotinib	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	study|nmod|START_ENTITY study|nmod|mutations mutations|compound|END_ENTITY	Phase II study of erlotinib as third-line monotherapy in patients with advanced non-small-cell_lung_cancer without epidermal_growth_factor_receptor mutations .
21743846	0	erlotinib	124,133	epidermal_growth_factor_receptor	7,39	erlotinib	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	use|amod|START_ENTITY determine|dobj|use lung_cancer|xcomp|determine lung_cancer|nsubj|Use Use|nmod|analysis analysis|compound|END_ENTITY	Use of epidermal_growth_factor_receptor mutation analysis in patients with advanced non-small-cell lung_cancer to determine erlotinib use as first-line therapy .
22045706	0	erlotinib	102,111	epidermal_growth_factor_receptor	59,91	erlotinib	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|PET/CT PET/CT|acl|monitoring monitoring|nmod|END_ENTITY	-LRB- 18 -RRB- F-FDG PET/CT for monitoring treatment responses to the epidermal_growth_factor_receptor inhibitor erlotinib .
22209766	0	erlotinib	77,86	epidermal_growth_factor_receptor	25,57	erlotinib	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Continuous inhibition of epidermal_growth_factor_receptor phosphorylation by erlotinib enhances antitumor activity of chemotherapy in erlotinib-resistant tumor xenografts .
22712792	0	erlotinib	23,32	epidermal_growth_factor_receptor	50,82	erlotinib	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	outcomes|nmod|START_ENTITY outcomes|nmod|patients patients|nmod|mutation mutation|compound|END_ENTITY	Clinical outcomes with erlotinib in patients with epidermal_growth_factor_receptor mutation .
22712793	0	erlotinib	8,17	epidermal_growth_factor_receptor	97,129	erlotinib	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	Role|nmod|START_ENTITY Role|dep|outcomes outcomes|nmod|patients patients|compound|END_ENTITY	Role of erlotinib in the treatment of non-small_cell_lung_cancer : clinical outcomes in wild-type epidermal_growth_factor_receptor patients .
22740981	0	erlotinib	143,152	epidermal_growth_factor_receptor	7,39	erlotinib	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|analysis analysis|compound|END_ENTITY	Plasma epidermal_growth_factor_receptor mutation analysis and possible clinical applications in pulmonary_adenocarcinoma patients treated with erlotinib .
22983065	0	erlotinib	17,26	epidermal_growth_factor_receptor	70,102	erlotinib	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	START_ENTITY|nmod|therapy therapy|nmod|patients patients|nmod|END_ENTITY	Effectiveness of erlotinib as a second line therapy for patients with epidermal_growth_factor_receptor -LRB- EGFR -RRB- mutation in non-small_cell_lung_cancer -LRB- NSCLC -RRB- : our clinical experience .
23095682	0	erlotinib	37,46	epidermal_growth_factor_receptor	81,113	erlotinib	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	responding|nmod|START_ENTITY responding|dep|time time|nmod|inhibition inhibition|nmod|END_ENTITY	Two cases of psoriasis responding to erlotinib : time to revisiting inhibition of epidermal_growth_factor_receptor in psoriasis therapy ? .
23249714	0	erlotinib	24,33	epidermal_growth_factor_receptor	48,80	erlotinib	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	resistance|amod|START_ENTITY resistance|nmod|cell cell|compound|END_ENTITY	-LSB- Molecular mechanism of erlotinib resistance in epidermal_growth_factor_receptor mutant non-small cell lung_cancer cell line H1650 -RSB- .
23319394	0	erlotinib	97,106	epidermal_growth_factor_receptor	121,153	erlotinib	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	resistance|amod|START_ENTITY resistance|nmod|cells cells|amod|END_ENTITY	The novel phosphoinositide 3-kinase-mammalian_target_of_rapamycin inhibitor , BEZ235 , circumvents erlotinib resistance of epidermal_growth_factor_receptor mutant lung_cancer cells triggered by hepatocyte_growth_factor .
23910906	0	erlotinib	66,75	epidermal_growth_factor_receptor	102,134	erlotinib	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	A prospective , phase II , open-label study -LRB- JO22903 -RRB- of first-line erlotinib in Japanese patients with epidermal_growth_factor_receptor -LRB- EGFR -RRB- mutation-positive advanced non-small-cell_lung_cancer -LRB- NSCLC -RRB- .
23993733	0	erlotinib	47,56	epidermal_growth_factor_receptor	163,195	erlotinib	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	therapy|compound|START_ENTITY pemetrexed|nmod|therapy study|nmod|pemetrexed advanced|nsubj|study advanced|nmod|documentation documentation|nmod|status status|compound|END_ENTITY	Phase II study of pemetrexed plus intermittent erlotinib combination therapy for pretreated advanced non-squamous non-small_cell_lung_cancer with documentation of epidermal_growth_factor_receptor mutation status .
24121455	0	erlotinib	18,27	epidermal_growth_factor_receptor	95,127	erlotinib	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	trial|nmod|START_ENTITY trial|dep|small small|dep|lung_cancer lung_cancer|acl|harboring harboring|dobj|mutations mutations|compound|END_ENTITY	Phase II trial of erlotinib in patients with advanced non - small - cell lung_cancer harboring epidermal_growth_factor_receptor mutations : additive analysis of pharmacokinetics .
24170435	0	erlotinib	134,143	epidermal_growth_factor_receptor	75,107	erlotinib	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	inhibitor|amod|START_ENTITY tyrosine|dobj|inhibitor tyrosine|nsubj|treatment treatment|nmod|models models|nmod|END_ENTITY	Combination treatment of human pancreatic_cancer xenograft models with the epidermal_growth_factor_receptor tyrosine kinase inhibitor erlotinib and oncolytic_herpes_simplex_virus_HF10 .
24196074	0	erlotinib	29,38	epidermal_growth_factor_receptor	76,108	erlotinib	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Assessing the usefulness of erlotinib in patients with unknown or negative epidermal_growth_factor_receptor mutation status -RSB- .
24458568	0	erlotinib	72,81	epidermal_growth_factor_receptor	122,154	erlotinib	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	acquired|nmod|START_ENTITY acquired|nmod|END_ENTITY	The insulin-like_growth_factor_1_receptor causes acquired resistance to erlotinib in lung_cancer cells with the wild-type epidermal_growth_factor_receptor .
25103305	0	erlotinib	203,212	epidermal_growth_factor_receptor	14,46	erlotinib	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	treatment|nmod|START_ENTITY tyrosine|nmod|treatment tyrosine|nsubj|Monitoring Monitoring|nmod|END_ENTITY	Monitoring of epidermal_growth_factor_receptor tyrosine kinase inhibitor-sensitizing and resistance mutations in the plasma DNA of patients with advanced non-small_cell_lung_cancer during treatment with erlotinib .
25187431	0	erlotinib	10,19	epidermal_growth_factor_receptor	40,72	erlotinib	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	derivative|amod|START_ENTITY TD-19|appos|derivative induces|nsubj|TD-19 induces|dobj|apoptosis apoptosis|amod|END_ENTITY	TD-19 , an erlotinib derivative , induces epidermal_growth_factor_receptor wild-type nonsmall-cell_lung_cancer apoptosis through CIP2A-mediated pathway .
25202264	0	erlotinib	100,109	epidermal_growth_factor_receptor	41,73	erlotinib	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	conferring|nmod|START_ENTITY conferring|nsubj|mutation mutation|nmod|exon exon|nmod|END_ENTITY	A novel insertion mutation on exon 20 of epidermal_growth_factor_receptor , conferring resistance to erlotinib .
26045797	0	erlotinib	14,23	epidermal_growth_factor_receptor	105,137	erlotinib	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	response|amod|START_ENTITY Biomarkers|nmod|response harbor|nsubj|Biomarkers harbor|dobj|mutations mutations|compound|END_ENTITY	Biomarkers of erlotinib response in non-small_cell_lung_cancer_tumors that do not harbor the more common epidermal_growth_factor_receptor mutations .
26153496	0	erlotinib	67,76	epidermal_growth_factor_receptor	246,278	erlotinib	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	trial|acl|START_ENTITY treated|nsubj|trial treated|dobj|nonsquamous_nonsmall-cell_lung_cancer nonsquamous_nonsmall-cell_lung_cancer|acl|harboring harboring|dobj|END_ENTITY	A randomized , double-blind , placebo-controlled , phase III trial of erlotinib with or without a c-Met inhibitor tivantinib -LRB- ARQ_197 -RRB- in Asian patients with previously treated stage IIIB/IV nonsquamous_nonsmall-cell_lung_cancer harboring wild-type epidermal_growth_factor_receptor -LRB- ATTENTION study -RRB- .
26386832	0	erlotinib	144,153	epidermal_growth_factor_receptor	28,60	erlotinib	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	treated|nmod|START_ENTITY patients|acl|treated predicts|nmod|patients predicts|nsubj|polymorphism polymorphism|nmod|gene gene|compound|END_ENTITY	Genetic polymorphism in the epidermal_growth_factor_receptor gene predicts outcome in advanced non-small_cell_lung_cancer patients treated with erlotinib .
26673416	0	erlotinib	39,48	epidermal_growth_factor_receptor	103,135	erlotinib	epidermal growth factor receptor	MESH:C400278	1956	Chemical	Gene	drug|appos|START_ENTITY Effect|nmod|drug Effect|acl|expressing expressing|dobj|levels levels|nmod|END_ENTITY	Effect of the molecular targeted drug , erlotinib , against endometrial_cancer expressing high levels of epidermal_growth_factor_receptor .
11557477	0	ertapenem	12,21	MK-0826	23,30	ertapenem	MK-0826	MESH:C446479	1476927(Tax:190192)	Chemical	Gene	Activity|nmod|START_ENTITY Activity|appos|END_ENTITY	Activity of ertapenem -LRB- MK-0826 -RRB- versus Enterobacteriaceae with potent beta-lactamases .
16309864	0	erythrodiol-3-acetate	25,46	matrix_metalloproteinase-9	68,94	erythrodiol-3-acetate	matrix metalloproteinase-9	MESH:C517014	4318	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	WITHDRAWN : The effect of erythrodiol-3-acetate on the expression of matrix_metalloproteinase-9 caused by ultraviolet-irradiated cultured human keratinocyte cells .
20669013	0	erythromycin	11,23	CYP2C19	78,85	erythromycin	CYP2C19	MESH:D004917	1557	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|polymorphism polymorphism|compound|END_ENTITY	Effects of erythromycin on voriconazole pharmacokinetics and association with CYP2C19 polymorphism .
10586386	0	erythromycin	33,45	CYP3A	105,110	erythromycin	CYP3A	MESH:D004917	1576	Chemical	Gene	test|amod|START_ENTITY administration|nmod|test administration|nmod|activity activity|compound|END_ENTITY	Concurrent administration of the erythromycin breath test -LRB- EBT -RRB- and oral midazolam as in vivo probes for CYP3A activity .
1526083	0	erythromycin	46,58	CYP3A	104,109	erythromycin	CYP3A	MESH:D004917	1576	Chemical	Gene	test|amod|START_ENTITY test|nmod|measures measures|nmod|P450IIIA P450IIIA|appos|END_ENTITY	Comparison of urinary 6-beta-cortisol and the erythromycin breath test as measures of hepatic P450IIIA -LRB- CYP3A -RRB- activity .
1732074	0	erythromycin	45,57	CYP3A	17,22	erythromycin	CYP3A	MESH:D004917	1576	Chemical	Gene	metabolizing|dobj|START_ENTITY isoforms|xcomp|metabolizing isoforms|nsubj|Heterogeneity Heterogeneity|nmod|END_ENTITY	Heterogeneity of CYP3A isoforms metabolizing erythromycin and cortisol .
19405994	0	erythromycin	197,209	CYP3A	169,174	erythromycin	CYP3A	MESH:D004917	170509(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|compound|END_ENTITY	Stress-induced cardiac_insufficiency relating to abnormal leptin and FKBP12 .6 is ameliorated by CPU0213 , an endothelin receptor antagonist , which is not affected by the CYP3A suppressing effect of erythromycin .
9505999	0	erythromycin	14,26	CYP3A	34,39	erythromycin	CYP3A	MESH:D004917	1576	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|component component|compound|END_ENTITY	The effect of erythromycin on the CYP3A component of sertindole clearance in healthy volunteers .
12534644	0	erythromycin	31,43	CYP3A4	14,20	erythromycin	CYP3A4	MESH:D004917	1576	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|inhibitor inhibitor|compound|END_ENTITY	Effect of the CYP3A4 inhibitor erythromycin on the pharmacokinetics of lignocaine and its pharmacologically active metabolites in subjects with normal and impaired_liver_function .
16042670	0	erythromycin	46,58	CYP3A4	110,116	erythromycin	CYP3A4	MESH:D004917	1576	Chemical	Gene	START_ENTITY|nmod|evidence evidence|nmod|involvement involvement|nmod|END_ENTITY	Inhibition of the metabolism of brotizolam by erythromycin in humans : in vivo evidence for the involvement of CYP3A4 in brotizolam metabolism .
17464949	0	erythromycin	104,116	CYP3A4	69,75	erythromycin	CYP3A4	MESH:D004917	1576	Chemical	Gene	test|amod|START_ENTITY measured|nmod|test measured|advmod|as as|nmod:npmod|activity activity|nummod|END_ENTITY	Assessment of ifosfamide pharmacokinetics , toxicity , and relation to CYP3A4 activity as measured by the erythromycin breath test in patients with sarcoma .
17922273	0	erythromycin	65,77	CYP3A4	32,38	erythromycin	CYP3A4	MESH:D004917	1576	Chemical	Gene	test|amod|START_ENTITY using|dobj|test activity|acl|using enzyme|dobj|activity enzyme|nsubj|Effect Effect|nmod|castration castration|nmod|END_ENTITY	Effect of medical castration on CYP3A4 enzyme activity using the erythromycin breath test .
18854379	0	erythromycin	28,40	CYP3A4	105,111	erythromycin	CYP3A4	MESH:D004917	1576	Chemical	Gene	effect|nmod|START_ENTITY Prediction|nmod|effect Prediction|nmod|inhibition inhibition|compound|END_ENTITY	Prediction of the effect of erythromycin , diltiazem , and their metabolites , alone and in combination , on CYP3A4 inhibition .
8646822	0	erythromycin	64,76	CYP3A4	128,134	erythromycin	CYP3A4	MESH:D004917	1576	Chemical	Gene	alprazolam|nmod|START_ENTITY alprazolam|nmod|evidence evidence|nmod|involvement involvement|nmod|END_ENTITY	A kinetic and dynamic study of oral alprazolam with and without erythromycin in humans : in vivo evidence for the involvement of CYP3A4 in alprazolam metabolism .
8959645	0	erythromycin	11,23	CYP3A4	99,105	erythromycin	CYP3A4	MESH:D004917	1576	Chemical	Gene	Effects|nmod|START_ENTITY catalyzed|nsubj|Effects catalyzed|nmod|END_ENTITY	Effects of erythromycin and roxithromycin on oxidation of testosterone and nifedipine catalyzed by CYP3A4 in human liver microsomes .
14743973	0	erythromycin	36,48	P-glycoprotein	10,24	erythromycin	P-glycoprotein	MESH:D004917	287115(Tax:10116)	Chemical	Gene	inhibitors|dobj|START_ENTITY inhibitors|nsubj|Effect Effect|nmod|END_ENTITY	Effect of P-glycoprotein inhibitors erythromycin and cyclosporin_A on brain pharmacokinetics of nimodipine in rats .
16268908	0	erythromycin	15,27	TNF-alpha	66,75	erythromycin	TNF-alpha	MESH:D004917	7124	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of erythromycin on the viability and the secretion of TNF-alpha and TGF-beta1 and expression of connexin43 by human pleural mesothelial cells .
19770275	0	erythromycin	79,91	esterase	92,100	erythromycin	esterase	MESH:D004917	14411281	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Characterization of a new metallo-beta-lactamase gene , bla -LRB- NDM-1 -RRB- , and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella_pneumoniae sequence type 14 from India .
15997121	0	erythromycin	11,23	gastrin	34,41	erythromycin	gastrin	MESH:D004917	2520	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of erythromycin on plasma gastrin , somatostatin , and motilin levels in healthy volunteers and postoperative_cancer patients .
10089966	0	erythromycin	21,33	interleukin-8	37,50	erythromycin	interleukin-8	MESH:D004917	3576	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|amod|END_ENTITY	Inhibitory effect of erythromycin on interleukin-8 secretion from exudative cells in the nasal discharge of patients with chronic sinusitis .
10092202	0	erythromycin	11,23	interleukin-8	47,60	erythromycin	interleukin-8	MESH:D004917	3576	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|release release|amod|END_ENTITY	Effects of erythromycin and its derivatives on interleukin-8 release by human bronchial epithelial cell line BEAS-2B cells .
16061006	0	erythromycin	12,24	interleukin-8	54,67	erythromycin	interleukin-8	MESH:D004917	3576	Chemical	Gene	START_ENTITY|nmod|synthesis synthesis|amod|END_ENTITY	-LSB- Effects of erythromycin on hydrogen_peroxide-induced interleukin-8 synthesis and regulation of glutathione in human bronchial epithelial cells -RSB- .
19567187	0	erythromycin	12,24	interleukin-8	45,58	erythromycin	interleukin-8	MESH:D004917	20309(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|synthesis synthesis|nmod|synthetase synthetase|amod|END_ENTITY	-LSB- Effects of erythromycin on the synthesis of interleukin-8 and gamma-glutamylcysteine synthetase induced by 4-hydroxynonenal in the bronchial epithelial cells -RSB- .
8726037	0	erythromycin	21,33	interleukin_8	37,50	erythromycin	interleukin 8	MESH:D004917	3576	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|production production|amod|END_ENTITY	Inhibitory effect of erythromycin on interleukin_8 production by 1 alpha,25-dihydroxyvitamin _ D3-stimulated THP-1 cells .
16037621	0	erythromycin	10,22	matrix_metalloproteinase-2	61,87	erythromycin	matrix metalloproteinase-2	MESH:D004917	81686(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Effect of erythromycin on homocysteine-induced extracellular matrix_metalloproteinase-2 production in cultured rat vascular smooth muscle cells .
1425065	0	erythromycin	10,22	motilin	125,132	erythromycin	motilin	MESH:D004917	4295	Chemical	Gene	Effect|nmod|START_ENTITY Effect|acl|emptying emptying|nmod|levels levels|nmod|END_ENTITY	Effect of erythromycin on gallbladder emptying in diabetic patients with and without autonomic_neuropathy and high levels of motilin .
17070443	0	erythromycin	19,31	motilin	2,9	erythromycin	motilin	MESH:D004917	4295	Chemical	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	A motilin agonist , erythromycin , decreases circulating growth_hormone levels in normal subjects but not in diabetic subjects .
2034824	0	erythromycin	10,22	motilin	44,51	erythromycin	motilin	MESH:D004917	100009276(Tax:9986)	Chemical	Gene	Effect|nmod|START_ENTITY octreotide|nsubj|Effect octreotide|nmod|density density|compound|END_ENTITY	Effect of erythromycin and of octreotide on motilin receptor density in the rabbit .
2381873	0	erythromycin	4,16	motilin	47,54	erythromycin	motilin	MESH:D004917	4295	Chemical	Gene	EM-523|amod|START_ENTITY agonist|nsubj|EM-523 agonist|compound|END_ENTITY	The erythromycin derivative EM-523 is a potent motilin agonist in man and in rabbit .
7965757	0	erythromycin	10,22	motilin	47,54	erythromycin	motilin	MESH:D004917	4295	Chemical	Gene	derivative|compound|START_ENTITY EM574|appos|derivative agonist|nsubj|EM574 agonist|compound|END_ENTITY	EM574 , an erythromycin derivative , is a potent motilin receptor agonist in human gastric antrum .
8026719	0	erythromycin	10,22	motilin	83,90	erythromycin	motilin	MESH:D004917	100009276(Tax:9986)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|comparison comparison|nmod|END_ENTITY	Effect of erythromycin on different parts of the rabbit intestine : comparison with motilin .
8482186	0	erythromycin	10,22	motilin	90,97	erythromycin	motilin	MESH:D004917	4295	Chemical	Gene	Effect|nmod|START_ENTITY contractile|nsubj|Effect contractile|dobj|concentration concentration|compound|END_ENTITY	Effect of erythromycin on interdigestive gastrointestinal contractile activity and plasma motilin concentration in humans .
9088872	0	erythromycin	10,22	motilin	40,47	erythromycin	motilin	MESH:D004917	100009276(Tax:9986)	Chemical	Gene	derivative|compound|START_ENTITY EM574|appos|derivative agonist|nsubj|EM574 agonist|amod|END_ENTITY	EM574 , an erythromycin derivative , is a motilin receptor agonist in the rabbit .
15708966	0	erythromycin	92,104	organic_anion_transporter_2	24,51	erythromycin	organic anion transporter 2	MESH:D004917	10864	Chemical	Gene	involvement|nmod|START_ENTITY involvement|nmod|END_ENTITY	Possible involvement of organic_anion_transporter_2 on the interaction of theophylline with erythromycin in the human liver .
24470082	0	erythrose-4-phosphate	61,82	phosphoglucose_isomerase	9,33	erythrose-4-phosphate	phosphoglucose isomerase	MESH:C026959	2821	Chemical	Gene	inhibition|nmod|START_ENTITY END_ENTITY|dep|inhibition	Oat leaf phosphoglucose_isomerase : competitive inhibition by erythrose-4-phosphate .
18362913	0	escitalopram	13,25	5-HT_1A_receptor	39,55	escitalopram	5-HT 1A receptor	MESH:D015283	3350	Chemical	Gene	treatment|compound|START_ENTITY treatment|nmod|END_ENTITY	Influence of escitalopram treatment on 5-HT_1A_receptor binding in limbic regions in patients with anxiety_disorders .
18048068	0	escitalopram	88,100	BDNF	31,35	escitalopram	BDNF	MESH:D015283	24225(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY days|nmod|treatment regulation|nmod|days regulation|nmod|levels levels|compound|END_ENTITY	The differential regulation of BDNF and TrkB levels in juvenile rats after four days of escitalopram and desipramine treatment .
20599917	0	escitalopram	26,38	BDNF	77,81	escitalopram	BDNF	MESH:D015283	24225(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|brain_derived_neurotrophic_factor brain_derived_neurotrophic_factor|appos|END_ENTITY	Time-dependent effects of escitalopram on brain_derived_neurotrophic_factor -LRB- BDNF -RRB- and neuroplasticity related targets in the central nervous system of rats .
21262856	0	escitalopram	48,60	BDNF	108,112	escitalopram	BDNF	MESH:D015283	24225(Tax:10116)	Chemical	Gene	Dissociation|nmod|START_ENTITY Dissociation|nmod|expression expression|compound|END_ENTITY	Dissociation of antidepressant-like activity of escitalopram and nortriptyline on behaviour and hippocampal BDNF expression in female rats .
21458451	0	escitalopram	30,42	BDNF	115,119	escitalopram	BDNF	MESH:D015283	627	Chemical	Gene	post-treatments|nmod|START_ENTITY protect|nsubj|post-treatments protect|nmod|neuronal_damage neuronal_damage|nmod|regulation regulation|nmod|expression expression|amod|END_ENTITY	Pre - and post-treatments with escitalopram protect against experimental ischemic neuronal_damage via regulation of BDNF expression and oxidative stress .
23793276	0	escitalopram	91,103	BDNF	35,39	escitalopram	BDNF	MESH:D015283	627	Chemical	Gene	treated|nmod|START_ENTITY women|acl|treated Brain_derived_neurotrophic_factor|nmod|women Brain_derived_neurotrophic_factor|dobj|levels levels|appos|END_ENTITY	Brain_derived_neurotrophic_factor -LRB- BDNF -RRB- levels in depressed women treated with open-label escitalopram .
24435333	0	escitalopram	11,23	BDNF	33,37	escitalopram	BDNF	MESH:D015283	627	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Effects of escitalopram on serum BDNF levels in elderly patients with depression : a preliminary report .
25074447	0	escitalopram	52,64	BDNF	4,8	escitalopram	BDNF	MESH:D015283	627	Chemical	Gene	response|compound|START_ENTITY associated|nmod|response associated|nsubjpass|polymorphism polymorphism|compound|Met Met|compound|END_ENTITY	The BDNF Val -LRB- 66 -RRB- Met polymorphism is associated with escitalopram response in depressed patients .
19272758	0	escitalopram	91,103	Serotonin_transporter	0,21	escitalopram	Serotonin transporter	MESH:D015283	6532	Chemical	Gene	influence|advcl|START_ENTITY influence|nsubj|polymorphisms polymorphisms|amod|END_ENTITY	Serotonin_transporter promoter region polymorphisms do not influence treatment response to escitalopram in patients with major_depression .
19771307	0	escitalopram	96,108	Serotonin_transporter	0,21	escitalopram	Serotonin transporter	MESH:D015283	6532	Chemical	Gene	inhibitor|appos|START_ENTITY reuptake|dobj|inhibitor reuptake|nsubj|polymorphism polymorphism|amod|END_ENTITY	Serotonin_transporter gene polymorphism and treatment response to serotonin reuptake inhibitor -LRB- escitalopram -RRB- in depression : An open pilot study .
20800901	0	escitalopram	54,66	Serotonin_transporter	0,21	escitalopram	Serotonin transporter	MESH:D015283	6532	Chemical	Gene	treatment|compound|START_ENTITY predictor|nmod|treatment polymorphism|nmod|predictor polymorphism|compound|END_ENTITY	Serotonin_transporter polymorphism as a predictor for escitalopram treatment of major depressive_disorder comorbid with alcohol_dependence .
25980484	0	escitalopram	35,47	Serotonin_transporter	0,21	escitalopram	Serotonin transporter	MESH:D015283	6532	Chemical	Gene	occupancy|nmod|START_ENTITY occupancy|nsubj|END_ENTITY	Serotonin_transporter occupancy by escitalopram and citalopram in the non-human primate brain : a -LSB- -LRB- 11 -RRB- C -RSB- MADAM PET study .
26892759	0	escitalopram	11,23	interleukin-10	98,112	escitalopram	interleukin-10	MESH:D015283	16153(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of escitalopram , R-citalopram , and reboxetine on serum levels of tumor_necrosis_factor-a , interleukin-10 , and depression-like behavior in mice after lipopolysaccharide administration .
16955282	0	escitalopram	136,148	serotonin_transporter	19,40	escitalopram	serotonin transporter	MESH:D015283	6532	Chemical	Gene	doses|nmod|START_ENTITY administered|dobj|doses subjects|acl|administered ADAM|nmod|subjects -RSB-|dobj|ADAM -RSB-|nmod|imaging imaging|nmod|occupancy occupancy|compound|END_ENTITY	In vivo imaging of serotonin_transporter occupancy by means of SPECT and -LSB- 123I -RSB- ADAM in healthy subjects administered different doses of escitalopram or citalopram .
17201996	0	escitalopram	68,80	serotonin_transporter	19,40	escitalopram	serotonin transporter	MESH:D015283	6532	Chemical	Gene	comparison|nmod|START_ENTITY measurement|dep|comparison measurement|nmod|occupancy occupancy|compound|END_ENTITY	PET measurement of serotonin_transporter occupancy : a comparison of escitalopram and citalopram .
17235610	0	escitalopram	77,89	serotonin_transporter	7,28	escitalopram	serotonin transporter	MESH:D015283	6532	Chemical	Gene	administration|nmod|START_ENTITY occupancy|nmod|administration occupancy|compound|END_ENTITY	Higher serotonin_transporter occupancy after multiple dose administration of escitalopram compared to citalopram : an -LSB- 123I -RSB- ADAM SPECT study .
18962988	0	escitalopram	41,53	serotonin_transporter	134,155	escitalopram	serotonin transporter	MESH:D015283	6532	Chemical	Gene	treatment|nmod|START_ENTITY weeks|nmod|treatment effect|nmod|weeks effect|dep|irrespective irrespective|nmod|genotype genotype|nmod|promoter promoter|nmod|END_ENTITY	No effect of six weeks of treatment with escitalopram on mood in healthy volunteers -- irrespective of genotype for the promoter of the serotonin_transporter .
19616061	0	escitalopram	89,101	serotonin_transporter	40,61	escitalopram	serotonin transporter	MESH:D015283	6532	Chemical	Gene	inhibition|nmod|START_ENTITY mediates|dobj|inhibition mediates|nsubj|site site|nmod|END_ENTITY	An allosteric binding site at the human serotonin_transporter mediates the inhibition of escitalopram by R-citalopram : kinetic binding studies with the ALI/VFL-SI/TT mutant .
21105279	0	escitalopram	67,79	serotonin_transporter	12,33	escitalopram	serotonin transporter	MESH:D015283	6532	Chemical	Gene	Relation|nmod|START_ENTITY Relation|nmod|variation variation|compound|END_ENTITY	Relation of serotonin_transporter genetic variation to efficacy of escitalopram for generalized anxiety_disorder in older adults .
24810106	0	escitalopram	19,31	serotonin_transporter	62,83	escitalopram	serotonin transporter	MESH:D015283	6532	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	The interaction of escitalopram and R-citalopram at the human serotonin_transporter investigated in the mouse .
24810870	0	escitalopram	66,78	serotonin_transporter	32,53	escitalopram	serotonin transporter	MESH:D015283	6532	Chemical	Gene	blockade|nmod|START_ENTITY blockade|compound|END_ENTITY	The impact of 5-HTTLPR on acute serotonin_transporter blockade by escitalopram on emotion processing : Preliminary findings from a randomised , crossover fMRI study .
26261165	0	escitalopram	120,132	serotonin_transporter	15,36	escitalopram	serotonin transporter	MESH:D015283	6532	Chemical	Gene	_|nmod|START_ENTITY _|nsubj|Association Association|nmod|END_ENTITY	Association of serotonin_transporter -LRB- SLC6A4 -RRB- _ receptor -LRB- 5HTR1A , 5HTR2A -RRB- polymorphisms with response to treatment with escitalopram in patients with major_depressive_disorder : A preliminary study .
26621784	0	escitalopram	25,37	serotonin_transporter	63,84	escitalopram	serotonin transporter	MESH:D015283	15567(Tax:10090)	Chemical	Gene	investigation|nmod|START_ENTITY site|nsubj|investigation site|nmod|END_ENTITY	In vivo investigation of escitalopram 's allosteric site on the serotonin_transporter .
8010057	0	esculentoside_H	10,25	tumor_necrosis_factor	40,61	esculentoside H	tumor necrosis factor	MESH:C062558	21926(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of esculentoside_H on release of tumor_necrosis_factor from mouse peritoneal macrophages .
12723615	0	esculetin	43,52	tyrosinase	9,19	esculetin	tyrosinase	MESH:C007628	7299	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Mushroom tyrosinase inhibitory activity of esculetin isolated from seeds of Euphorbia lathyris L .
17143474	0	eserine	50,57	acetylcholinesterase	62,82	eserine	acetylcholinesterase	MESH:D010830	83817(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Cell proliferation and tumor formation induced by eserine , an acetylcholinesterase inhibitor , in rat mammary gland .
25143547	0	eserine	35,42	acetylcholinesterase	3,23	eserine	acetylcholinesterase	MESH:D010830	83817(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	An acetylcholinesterase inhibitor , eserine , induces long-term depression at CA3-CA1 synapses in the hippocampus of adult rats .
7612051	0	esmolol	52,59	Beta_1-adrenoceptor	0,19	esmolol	Beta 1-adrenoceptor	MESH:C036604	153	Chemical	Gene	antagonism|nmod|START_ENTITY subtype|dobj|antagonism subtype|nsubj|END_ENTITY	Beta_1-adrenoceptor subtype selective antagonism of esmolol and its major metabolite in vitro and in man .
15728061	0	esmolol	48,55	beta1-adrenoceptor	17,35	esmolol	beta1-adrenoceptor	MESH:C036604	153	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|amod|END_ENTITY	The short-acting beta1-adrenoceptor antagonists esmolol and landiolol suppress the bispectral index response to tracheal intubation during sevoflurane anesthesia .
11816552	0	esomeprazole	44,56	proton_pump	90,101	esomeprazole	proton pump	MESH:D064098	495	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Clinical pharmacology and safety profile of esomeprazole , the first enantiomerically pure proton_pump inhibitor .
15344530	0	esophageal_acid	78,93	gastroesophageal_reflux	40,63	esophageal acid	gastroesophageal reflux	null	59330	Chemical	Gene	-RSB-|amod|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Pathophysiology of GERD : mechanisms of gastroesophageal_reflux and prolonged esophageal_acid exposure time -RSB- .
18472120	0	ester	69,74	C-3	90,93	ester	C-3	CHEBI:35701	24232(Tax:10116)	Chemical	Gene	chains|compound|START_ENTITY chains|nmod|END_ENTITY	Biological activity of novel progesterone derivatives having a bulky ester side chains at C-3 .
1995872	0	ester	94,99	angiotensin_converting_enzyme	122,151	ester	angiotensin converting enzyme	CHEBI:35701	1636	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	Molecular and crystal_structures of MDL27 ,467 A hydrochloride and quinapril_hydrochloride , two ester derivatives of potent angiotensin_converting_enzyme inhibitors .
19285387	0	ester	146,151	lipase	82,88	ester	lipase	CHEBI:35701	24997148	Chemical	Gene	synthesis|compound|START_ENTITY END_ENTITY|nmod|synthesis	Production , partial purification and characterization of organic solvent tolerant lipase from Burkholderia_multivorans V2 and its application for ester synthesis .
4745509	0	esters	53,59	bradykinin	13,23	esters	bradykinin	MESH:D004952	3827	Chemical	Gene	Synthesis|nmod|START_ENTITY Synthesis|nmod|END_ENTITY	Synthesis of bradykinin via oximinopyrazoline active esters -LRB- OPmp -RRB- .
26190908	0	esters	30,36	cathepsin_C	75,86	esters	cathepsin C	MESH:D004952	1075	Chemical	Gene	Synthesis|nmod|START_ENTITY Synthesis|nmod|inhibitors inhibitors|nmod|END_ENTITY	Synthesis of dehydrodipeptide esters and their evaluation as inhibitors of cathepsin_C .
20207142	0	esters	6,12	retinoblastoma-binding_protein_9	71,103	esters	retinoblastoma-binding protein 9	MESH:D004952	10741	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Oxime esters as selective , covalent inhibitors of the serine hydrolase retinoblastoma-binding_protein_9 -LRB- RBBP9 -RRB- .
4004926	0	estradiol	98,107	15-hydroxyprostaglandin_dehydrogenase	48,85	estradiol	15-hydroxyprostaglandin dehydrogenase	MESH:D004958	79242(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Induction of a decrease in renal NAD + - dependent 15-hydroxyprostaglandin_dehydrogenase activity by estradiol in rats .
9408882	0	estradiol	13,22	ACTH	46,50	estradiol	ACTH	MESH:D004958	5443	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of estradiol and androstenedione on ACTH and cortisol secretion in the ovine fetus .
2838267	0	estradiol	68,77	AII	85,88	estradiol	AII	MESH:D004958	24179(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Angiotensin_II _ -LRB- AII -RRB- and adrenocorticotropin release : modulation by estradiol of the AII biological activity and binding characteristics in anterior pituitary dispersed cells .
26628404	0	estradiol	8,17	AMPK	41,45	estradiol	AMPK	MESH:D004958	78975(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY END_ENTITY|nsubj|Role	Role of estradiol in intrinsic hindbrain AMPK regulation of hypothalamic AMPK , metabolic neuropeptide , and norepinephrine activity and food intake in the female rat .
19935720	0	estradiol	118,127	Adenosine_A1_receptor	0,21	estradiol	Adenosine A1 receptor	MESH:D004958	134	Chemical	Gene	effects|nmod|START_ENTITY mediates|dobj|effects mediates|nsubj|END_ENTITY	Adenosine_A1_receptor , a target and regulator of estrogen receptoralpha action , mediates the proliferative effects of estradiol in breast_cancer .
15183692	0	estradiol	10,19	Akt	52,55	estradiol	Akt	MESH:D004958	24185(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|protein protein|compound|END_ENTITY	Effect of estradiol on expression and activation of Akt protein in rat hypothalamus exposed to chronic -LSB- D-Met2 , Pro5 -RSB- - enkephalinamide treatment .
24922551	0	estradiol	158,167	Alpha-fetoprotein	0,17	estradiol	Alpha-fetoprotein	MESH:D004958	174	Chemical	Gene	presence|nmod|START_ENTITY activity|nmod|presence exhibits|dobj|activity exhibits|nsubj|END_ENTITY	Alpha-fetoprotein , identified as a novel marker for the antioxidant effect of placental extract , exhibits synergistic antioxidant activity in the presence of estradiol .
7714093	0	estradiol	26,35	Angiotensin-II	0,14	estradiol	Angiotensin-II	MESH:D004958	183	Chemical	Gene	secretion|amod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Angiotensin-II stimulates estradiol secretion from human placental explants through AT1 receptor activation .
1955187	0	estradiol	55,64	BG-1	23,27	estradiol	BG-1	MESH:D004958	23205	Chemical	Gene	cells|nmod|START_ENTITY cells|compound|END_ENTITY	The growth response of BG-1 ovarian_carcinoma cells to estradiol , 4OH-tamoxifen , and tamoxifen : evidence for intrinsic antiestrogen activation .
8895551	0	estradiol	19,28	Bcl-2	46,51	estradiol	Bcl-2	MESH:D004958	596	Chemical	Gene	Antagonism|nmod|START_ENTITY Antagonism|nmod|expression expression|compound|END_ENTITY	Antagonism between estradiol and progestin on Bcl-2 expression in breast-cancer cells .
2351224	0	estradiol	31,40	CA-125	9,15	estradiol	CA-125	MESH:D004958	94025	Chemical	Gene	protein|dep|START_ENTITY protein|compound|END_ENTITY	Relaxin , CA-125 , progesterone , estradiol , Schwangerschaft protein , and human chorionic gonadotropin as predictors of outcome in threatened and nonthreatened pregnancies .
7790911	0	estradiol	11,20	CA1	97,100	estradiol	CA1	MESH:D004958	310218(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|neurons neurons|compound|END_ENTITY	Effects of estradiol and progesterone on voltage-gated calcium and potassium conductances in rat CA1 hippocampal neurons .
12852833	0	estradiol	10,19	CXCR2	42,47	estradiol	CXCR2	MESH:D004958	29385(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effect of estradiol on chemokine receptor CXCR2 expression in rats : implications for atherosclerosis .
10862525	0	estradiol	54,63	CYP1B1	22,28	estradiol	CYP1B1	MESH:D004958	1545	Chemical	Gene	conversion|nmod|START_ENTITY affect|dobj|conversion affect|nsubj|Polymorphisms Polymorphisms|nmod|END_ENTITY	Polymorphisms in P450 CYP1B1 affect the conversion of estradiol to the potentially carcinogenic metabolite 4-hydroxyestradiol .
15126349	0	estradiol	29,38	CYP1B1	6,12	estradiol	CYP1B1	MESH:D004958	1545	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Human CYP1B1 is regulated by estradiol via estrogen_receptor .
20462226	0	estradiol	62,71	CYP1B1	14,20	estradiol	CYP1B1	MESH:D004958	1545	Chemical	Gene	4-hydroxylation|nmod|START_ENTITY explains|dobj|4-hydroxylation explains|nsubj|model model|nmod|END_ENTITY	A 3D model of CYP1B1 explains the dominant 4-hydroxylation of estradiol .
23821647	0	estradiol	35,44	CYP1B1	28,34	estradiol	CYP1B1	MESH:D004958	1545	Chemical	Gene	START_ENTITY|nsubj|determinants determinants|nmod|END_ENTITY	Specificity determinants of CYP1B1 estradiol hydroxylation .
22815312	0	estradiol	47,56	CYP2B6	27,33	estradiol	CYP2B6	MESH:D004958	1555	Chemical	Gene	induction|nmod|START_ENTITY induction|nummod|END_ENTITY	Quantitative prediction of CYP2B6 induction by estradiol during pregnancy : potential explanation for increased methadone clearance during pregnancy .
10072167	0	estradiol	23,32	Cyp1a-1	118,125	estradiol	Cyp1a-1	MESH:D004958	13076(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activation activation|nmod|END_ENTITY	Suppressive effects of estradiol on 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated transcriptional activation of murine Cyp1a-1 in mouse hepatoma Hepa 1c1c7 cells .
9221823	0	estradiol	30,39	Cytochrome_P450	0,15	estradiol	Cytochrome P450	MESH:D004958	25251(Tax:10116)	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|amod|END_ENTITY	Cytochrome_P450 metabolism of estradiol in hamster liver and kidney .
9614644	0	estradiol	10,19	DHEAS	23,28	estradiol	DHEAS	MESH:D004958	6822	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|production production|compound|END_ENTITY	Effect of estradiol on DHEAS production in the human adrenocortical cell line , H295R .
12737316	0	estradiol	35,44	ER-beta	24,31	estradiol	ER-beta	MESH:D004958	2100	Chemical	Gene	modulation|nmod|START_ENTITY modulation|nmod|END_ENTITY	Selective modulation of ER-beta by estradiol and xenoestrogens in human breast_cancer cell lines .
2220261	0	estradiol	44,53	Epidermal_growth_factor	0,23	estradiol	Epidermal growth factor	MESH:D004958	13645(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|dep|effects	Epidermal_growth_factor in mice : effects of estradiol , testosterone and dexamethasone .
8003713	0	estradiol	93,102	Epidermal_growth_factor	0,23	estradiol	Epidermal growth factor	MESH:D004958	25313(Tax:10116)	Chemical	Gene	treatment|nmod|START_ENTITY anterior|nmod|treatment anterior|nsubj|END_ENTITY	Epidermal_growth_factor and prolactin in rat anterior pituitary after chronic treatment with estradiol and triiodothyronine .
8248035	0	estradiol	39,48	Epidermal_growth_factor	0,23	estradiol	Epidermal growth factor	MESH:D004958	25313(Tax:10116)	Chemical	Gene	replaces|xcomp|START_ENTITY replaces|nsubj|END_ENTITY	Epidermal_growth_factor -LRB- EGF -RRB- replaces estradiol for the initiation of embryo implantation in the hypophysectomized rat .
8286569	0	estradiol	132,141	Epidermal_growth_factor	0,23	estradiol	Epidermal growth factor	MESH:D004958	100714471	Chemical	Gene	do|nsubj|START_ENTITY induce|advcl|do induce|nsubj|END_ENTITY	Epidermal_growth_factor and insulin induce the proliferation of guinea_pig endometrial stromal cells in serum-free culture , whereas estradiol and progesterone do not .
7060523	0	estradiol	109,118	Estrogen_receptor	0,17	estradiol	Estrogen receptor	MESH:D004958	2099	Chemical	Gene	activation|acl|START_ENTITY END_ENTITY|dep|activation	Estrogen_receptor in avian embryo and adult liver : estrogen_receptor activation and dissociation kinetics of estradiol , ethynylestradiol , and moxestrol .
8542308	0	estradiol	67,76	Estrogen_receptor	0,17	estradiol	Estrogen receptor	MESH:D004958	2099	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|immunoreactivity immunoreactivity|amod|END_ENTITY	Estrogen_receptor immunoreactivity in ferret brain is regulated by estradiol in a region-specific manner .
12878732	0	estradiol	72,81	Estrogen_receptor-alpha	0,23	estradiol	Estrogen receptor-alpha	MESH:D004958	13982(Tax:10090)	Chemical	Gene	activity|nmod|START_ENTITY mediates|dobj|activity mediates|nsubj|END_ENTITY	Estrogen_receptor-alpha mediates the brain antiinflammatory activity of estradiol .
15952176	0	estradiol	33,42	Estrogen_receptor-alpha	0,23	estradiol	Estrogen receptor-alpha	MESH:D004958	13982(Tax:10090)	Chemical	Gene	attenuation|amod|START_ENTITY attenuation|amod|END_ENTITY	Estrogen_receptor-alpha mediates estradiol attenuation of ATP-induced Ca2 + signaling in mouse dorsal root ganglion neurons .
18719354	0	estradiol	48,57	Estrogen_receptor-alpha	0,23	estradiol	Estrogen receptor-alpha	MESH:D004958	2099	Chemical	Gene	effects|nmod|START_ENTITY mediates|dobj|effects mediates|nsubj|END_ENTITY	Estrogen_receptor-alpha mediates the effects of estradiol on telomerase activity in human mesenchymal stem cells .
25108195	0	estradiol	65,74	Estrogen_receptor-alpha	0,23	estradiol	Estrogen receptor-alpha	MESH:D004958	2099	Chemical	Gene	effect|nmod|START_ENTITY mediates|dobj|effect mediates|nsubj|END_ENTITY	Estrogen_receptor-alpha 36 mediates the anti-apoptotic effect of estradiol in triple negative breast_cancer cells via a membrane-associated mechanism .
11566716	0	estradiol	39,48	Fas_ligand	14,24	estradiol	Fas ligand	MESH:D004958	356	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of Fas_ligand expression by estradiol and progesterone in human endometrium .
21683086	0	estradiol	36,45	GFAP	89,93	estradiol	GFAP	MESH:D004958	24387(Tax:10116)	Chemical	Gene	treatment|nmod|START_ENTITY modifies|nsubj|treatment modifies|dobj|expression expression|nmod|END_ENTITY	Short - and long-term treatment with estradiol or progesterone modifies the expression of GFAP , MAP2 and Tau in prefrontal cortex and hippocampus .
10946861	0	estradiol	5,14	GH	110,112	estradiol	GH	MESH:D004958	2688	Chemical	Gene	administration|amod|START_ENTITY modulates|nsubj|administration modulates|dep|releasing releasing|dobj|secretion secretion|compound|END_ENTITY	Oral estradiol administration modulates continuous intravenous growth_hormone -LRB- GH -RRB- - releasing peptide-2-driven GH secretion in postmenopausal women .
10946861	0	estradiol	5,14	GH	79,81	estradiol	GH	MESH:D004958	2688	Chemical	Gene	administration|amod|START_ENTITY modulates|nsubj|administration modulates|dep|releasing releasing|nsubj|growth_hormone growth_hormone|appos|END_ENTITY	Oral estradiol administration modulates continuous intravenous growth_hormone -LRB- GH -RRB- - releasing peptide-2-driven GH secretion in postmenopausal women .
11158008	0	estradiol	11,20	GH	62,64	estradiol	GH	MESH:D004958	2688	Chemical	Gene	augments|amod|START_ENTITY growth_hormone|nsubj|augments growth_hormone|dobj|responsiveness responsiveness|appos|END_ENTITY	Short-term estradiol supplementation augments growth_hormone -LRB- GH -RRB- secretory responsiveness to dose-varying GH-releasing peptide infusions in healthy postmenopausal women .
11437472	0	estradiol	24,33	GH	107,109	estradiol	GH	MESH:D004958	14599(Tax:10090)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Growth_hormone -LRB- GH -RRB- and estradiol regulation of membrane-associated_GH_binding_protein and GH_receptors in GH releasing hormone transgenic_mice .
17537842	0	estradiol	95,104	GH	36,38	estradiol	GH	MESH:D004958	2688	Chemical	Gene	clamp|amod|START_ENTITY using|dobj|clamp women|acl|using bursts|nmod|women bursts|nsubj|Estimation Estimation|nmod|size size|nmod|END_ENTITY	Estimation of the size and shape of GH secretory bursts in healthy women using a physiological estradiol clamp and variable-waveform deconvolution model .
19616401	0	estradiol	13,22	GH	49,51	estradiol	GH	MESH:D004958	443329(Tax:9940)	Chemical	Gene	doses|nmod|START_ENTITY inhibit|nsubj|doses inhibit|dobj|release release|nmod|END_ENTITY	Low doses of estradiol partly inhibit release of GH in sheep without affecting basal levels .
2281029	0	estradiol	63,72	GH	16,18	estradiol	GH	MESH:D004958	81668(Tax:10116)	Chemical	Gene	administered|dobj|START_ENTITY animals|acl|administered Growth_hormone|nmod|animals Growth_hormone|dobj|dynamics dynamics|appos|END_ENTITY	Growth_hormone -LRB- GH -RRB- secretory dynamics in animals administered estradiol utilizing a chemical delivery system .
23342919	0	estradiol	46,55	GH	33,35	estradiol	GH	MESH:D004958	378781(Tax:9031)	Chemical	Gene	secretion|amod|START_ENTITY action|nmod|secretion END_ENTITY|dobj|action	Independent , non-IGF-I mediated , GH action on estradiol secretion by prehierarchical ovarian_follicles in chicken .
24736568	0	estradiol	21,30	GPER-1	14,20	estradiol	GPER-1	MESH:D004958	2852	Chemical	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Activation of GPER-1 estradiol receptor downregulates production of testosterone in isolated rat Leydig cells and adult human testis .
16870949	0	estradiol	11,20	GnRH	33,37	estradiol	GnRH	MESH:D004958	2796	Chemical	Gene	infusion|amod|START_ENTITY infusion|nmod|END_ENTITY	Effects of estradiol infusion in GnRH immunized boars on spermatogenesis .
8730652	0	estradiol	45,54	GnRH	29,33	estradiol	GnRH	MESH:D004958	25194(Tax:10116)	Chemical	Gene	neurons|nmod|START_ENTITY neurons|nsubj|Induction Induction|nmod|mRNA mRNA|nmod|END_ENTITY	Induction of galanin mRNA in GnRH neurons by estradiol and its facilitation by progesterone .
2492233	0	estradiol	88,97	Gonadotropin-releasing_hormone	0,30	estradiol	Gonadotropin-releasing hormone	MESH:D004958	2796	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|sensitivity sensitivity|amod|END_ENTITY	Gonadotropin-releasing_hormone pacemaker sensitivity to negative feedback inhibition by estradiol in women with hypothalamic_amenorrhea .
7895666	0	estradiol	109,118	Gonadotropin-releasing_hormone	0,30	estradiol	Gonadotropin-releasing hormone	MESH:D004958	25194(Tax:10116)	Chemical	Gene	augmentation|nmod|START_ENTITY END_ENTITY|dep|augmentation	Gonadotropin-releasing_hormone -LRB- GnRH -RRB- pulse pattern regulates GnRH_receptor gene expression : augmentation by estradiol .
2281029	0	estradiol	63,72	Growth_hormone	0,14	estradiol	Growth hormone	MESH:D004958	81668(Tax:10116)	Chemical	Gene	administered|dobj|START_ENTITY animals|acl|administered END_ENTITY|nmod|animals	Growth_hormone -LRB- GH -RRB- secretory dynamics in animals administered estradiol utilizing a chemical delivery system .
8941060	0	estradiol	24,33	Growth_hormone	0,14	estradiol	Growth hormone	MESH:D004958	2688	Chemical	Gene	follicle-stimulating|amod|START_ENTITY enhances|dobj|follicle-stimulating enhances|nsubj|END_ENTITY	Growth_hormone enhances estradiol production follicle-stimulating hormone-induced in the early stage of the follicular maturation .
23375982	0	estradiol	88,97	HOTAIR	49,55	estradiol	HOTAIR	MESH:D004958	100124700	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Antisense transcript long noncoding RNA -LRB- lncRNA -RRB- HOTAIR is transcriptionally induced by estradiol .
21372145	0	estradiol	41,50	HSD17B7	19,26	estradiol	HSD17B7	MESH:D004958	51478	Chemical	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	The stimulation of HSD17B7 expression by estradiol provides a powerful feed-forward mechanism for estradiol biosynthesis in breast_cancer cells .
22072674	0	estradiol	69,78	Hsp70	107,112	estradiol	Hsp70	MESH:D004958	266759(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	Morphine protects against intracellular amyloid_toxicity by inducing estradiol release and upregulation of Hsp70 .
8902198	0	estradiol	69,78	IGF-I	0,5	estradiol	IGF-I	MESH:D004958	3479	Chemical	Gene	mediate|nmod|START_ENTITY mediate|nsubj|END_ENTITY	IGF-I does not mediate T-lymphoblast colony formation in response to estradiol , testosterone , 1,25 -LRB- OH -RRB- 2_vitamin_D3 , and triiodothyronine : studies in control and pygmy T-cell lines .
9435457	5	estradiol	621,630	IGFBP-4	610,617	estradiol	IGFBP-4	MESH:D004958	3487	Chemical	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	Inhibition by IGFBP-4 of estradiol production in the presence of testosterone alone was seen in three of four experiments .
17986638	0	estradiol	47,56	Insulin	0,7	estradiol	Insulin	MESH:D004958	3630	Chemical	Gene	administration|amod|START_ENTITY secretion|nmod|administration secretion|compound|END_ENTITY	Insulin secretion and clearance after subacute estradiol administration in postmenopausal women .
7684393	0	estradiol	100,109	Insulin-like_growth_factor-I	0,28	estradiol	Insulin-like growth factor-I	MESH:D004958	3479	Chemical	Gene	secretion|amod|START_ENTITY stimulating|dobj|secretion IGF-binding_protein-1|dep|stimulating production|nmod|IGF-binding_protein-1 inhibits|dobj|production inhibits|nsubj|END_ENTITY	Insulin-like_growth_factor-I -LRB- IGF-I -RRB- inhibits production of IGF-binding_protein-1 while stimulating estradiol secretion in granulosa cells from normal and polycystic human ovaries .
2972358	0	estradiol	84,93	Insulin-like_growth_factor_1	0,28	estradiol	Insulin-like growth factor 1	MESH:D004958	3479	Chemical	Gene	receptors|nmod|START_ENTITY receptors|amod|END_ENTITY	Insulin-like_growth_factor_1 receptors in human breast_cancer and their relation to estradiol and progesterone_receptors .
9798135	0	estradiol	82,91	Insulin-like_growth_factor_I	0,28	estradiol	Insulin-like growth factor I	MESH:D004958	3479	Chemical	Gene	treatment|amod|START_ENTITY serum|nmod|treatment serum|nsubj|END_ENTITY	Insulin-like_growth_factor_I -LRB- IGF-I -RRB- serum level modifications during transdermal estradiol treatment in postmenopausal women : a possible bimodal effect depending on basal IGF-I values .
15619685	0	estradiol	78,87	Interleukin-6	51,64	estradiol	Interleukin-6	MESH:D004958	3569	Chemical	Gene	START_ENTITY|advcl|-LSB- -LSB-|dobj|association association|nmod|level level|compound|END_ENTITY	-LSB- The association between gingival cervicular fluid Interleukin-6 level , serum estradiol status and periodontitis in Uyghur postmenopausal women -RSB- .
15691879	0	estradiol	76,85	LRP16	43,48	estradiol	LRP16	MESH:D004958	28992	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Mechanism of transcriptional regulation of LRP16 gene expression by 17-beta estradiol in MCF-7 human breast_cancer cells .
16012748	0	estradiol	10,19	MUC1	38,42	estradiol	MUC1	MESH:D004958	4582	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of estradiol and raloxifene on MUC1 expression and adhesive properties of Ishikawa cells .
21846797	0	estradiol	41,50	Micro-RNA378	0,12	estradiol	Micro-RNA378	MESH:D004958	494327	Chemical	Gene	production|amod|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	Micro-RNA378 -LRB- miR-378 -RRB- regulates ovarian estradiol production by targeting aromatase .
23810756	0	estradiol	33,42	MicroRNA-133b	0,13	estradiol	MicroRNA-133b	MESH:D004958	442890	Chemical	Gene	synthesis|amod|START_ENTITY stimulates|dobj|synthesis stimulates|nsubj|END_ENTITY	MicroRNA-133b stimulates ovarian estradiol synthesis by targeting Foxl2 .
17641044	0	estradiol	87,96	NF-kappa_B	110,120	estradiol	NF-kappa B	MESH:D004958	18033(Tax:10090)	Chemical	Gene	up-regulates|amod|START_ENTITY END_ENTITY|nsubj|up-regulates	Despite inhibition of nuclear localization of NF-kappa_B p65 , c-Rel , and RelB , 17-beta estradiol up-regulates NF-kappa_B signaling in mouse splenocytes : the potential role of Bcl-3 .
17641044	0	estradiol	87,96	NF-kappa_B	46,56	estradiol	NF-kappa B	MESH:D004958	18033(Tax:10090)	Chemical	Gene	up-regulates|amod|START_ENTITY NF-kappa_B|nsubj|up-regulates NF-kappa_B|nmod|inhibition inhibition|nmod|localization localization|nmod|p65 p65|amod|END_ENTITY	Despite inhibition of nuclear localization of NF-kappa_B p65 , c-Rel , and RelB , 17-beta estradiol up-regulates NF-kappa_B signaling in mouse splenocytes : the potential role of Bcl-3 .
8824322	0	estradiol	54,63	NMDAR1	27,33	estradiol	NMDAR1	MESH:D004958	24408(Tax:10116)	Chemical	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	Differential regulation of NMDAR1 mRNA and protein by estradiol in the rat hippocampus .
12174911	0	estradiol	27,36	P-glycoprotein	40,54	estradiol	P-glycoprotein	MESH:D004958	5243	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Differential modulation by estradiol of P-glycoprotein drug resistance protein expression in cultured MCF7 and T47D breast_cancer cells .
17923326	0	estradiol	41,50	P-glycoprotein	0,14	estradiol	P-glycoprotein	MESH:D004958	67078(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY has|dobj|effects has|nsubj|END_ENTITY	P-glycoprotein has negligible effects on estradiol and testosterone in mice .
8964876	0	estradiol	11,20	P-selectin	36,46	estradiol	P-selectin	MESH:D004958	6403	Chemical	Gene	START_ENTITY|acl|circulating circulating|dobj|END_ENTITY	Effects of estradiol on circulating P-selectin .
22168360	0	estradiol	21,30	PAX2	0,4	estradiol	PAX2	MESH:D004958	5076	Chemical	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	PAX2 is activated by estradiol in breast_cancer cells of the luminal subgroup selectively , to confer a low invasive phenotype .
16513679	0	estradiol	49,58	PKCalpha	18,26	estradiol	PKCalpha	MESH:D004958	5578	Chemical	Gene	inhibition|amod|START_ENTITY impart|dobj|inhibition required|xcomp|impart required|nsubjpass|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of PKCalpha is required to impart estradiol inhibition and tamoxifen-resistance in a T47D human breast_cancer_tumor model .
18534651	0	estradiol	81,90	PKCalpha	41,49	estradiol	PKCalpha	MESH:D004958	5578	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Membrane ERalpha-dependent activation of PKCalpha in endometrial_cancer cells by estradiol .
19281799	0	estradiol	21,30	PPT	71,74	estradiol	PPT	MESH:D004958	24806(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nsubj|effects	Divergent effects of estradiol and the estrogen_receptor-alpha agonist PPT on eating and activation of PVN CRH neurons in ovariectomized rats and mice .
12781042	0	estradiol	96,105	PTEN	20,24	estradiol	PTEN	MESH:D004958	5728	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Role Role|nmod|END_ENTITY	Role of phosphatase PTEN in the activation of extracellular_signal-regulated_kinases induced by estradiol in endometrial_carcinoma cells .
14557489	0	estradiol	91,100	PTEN	14,18	estradiol	PTEN	MESH:D004958	5728	Chemical	Gene	expression|nmod|START_ENTITY expression|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of PTEN -LRB- phosphatase and tensin homolog deleted on chromosome 10 -RRB- expression by estradiol and progesterone in human endometrium .
3807787	0	estradiol	41,50	Parathyroid_hormone	0,19	estradiol	Parathyroid hormone	MESH:D004958	5741	Chemical	Gene	effect|nmod|START_ENTITY secretion|dep|effect secretion|amod|END_ENTITY	Parathyroid_hormone secretion : effect of estradiol and progesterone .
17761890	0	estradiol	36,45	Per1	17,21	estradiol	Per1	MESH:D004958	287422(Tax:10116)	Chemical	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|expression expression|amod|END_ENTITY	Up-regulation of Per1 expression by estradiol and progesterone in the rat uterus .
8213106	0	estradiol	92,101	Progesterone_receptor	0,21	estradiol	Progesterone receptor	MESH:D004958	5241	Chemical	Gene	levels|nmod|START_ENTITY correlates|nmod|levels correlates|nsubj|content content|amod|END_ENTITY	Progesterone_receptor content in endometrial_carcinoma correlates with serum levels of free estradiol .
2744187	0	estradiol	83,92	Prolactin	0,9	estradiol	Prolactin	MESH:D004958	5617	Chemical	Gene	stimulates|xcomp|START_ENTITY stimulates|nsubj|suppression suppression|compound|END_ENTITY	Prolactin suppression by bromocriptine stimulates aromatization of testosterone to estradiol in women .
4771991	0	estradiol	46,55	Prolactin	0,9	estradiol	Prolactin	MESH:D004958	5617	Chemical	Gene	effect|nmod|START_ENTITY effect|compound|END_ENTITY	Prolactin and progesterone effect on specific estradiol binding in uterine and mammary tissues in vitro .
7067928	0	estradiol	74,83	Prolactin	0,9	estradiol	Prolactin	MESH:D004958	5617	Chemical	Gene	regulation|nmod|START_ENTITY synthesis|dep|regulation synthesis|compound|END_ENTITY	Prolactin synthesis in primary cultures of pituitary cells : regulation by estradiol .
22238094	0	estradiol	41,50	SPAK	8,12	estradiol	SPAK	MESH:D004958	54348(Tax:10116)	Chemical	Gene	upregulated|nmod|START_ENTITY upregulated|nsubjpass|END_ENTITY	Kinases SPAK and OSR1 are upregulated by estradiol and activate NKCC1 in the developing hypothalamus .
16221673	5	estradiol	699,708	SULT1A1	718,725	estradiol	SULT1A1	MESH:D004958	6817	Chemical	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	To investigate how estradiol binds to SULT1A1 , we co-crystallized SULT1A1 with sulfated estradiol and the cofactor product , PAP -LRB- 3 ' - phosphoadenosine_5 ' - phosphate -RRB- .
10419027	0	estradiol	108,117	Sex_hormone-binding_globulin	0,28	estradiol	Sex hormone-binding globulin	MESH:D004958	6462	Chemical	Gene	action|amod|START_ENTITY modulation|nmod|action approach|nmod|modulation END_ENTITY|dep|approach	Sex_hormone-binding_globulin , its membrane receptor , and breast_cancer : a new approach to the modulation of estradiol action in neoplastic cells .
15664449	0	estradiol	70,79	Sex_hormone-binding_globulin	0,28	estradiol	Sex hormone-binding globulin	MESH:D004958	6462	Chemical	Gene	effect|nmod|START_ENTITY antagonizes|dobj|effect antagonizes|nsubj|END_ENTITY	Sex_hormone-binding_globulin antagonizes the anti-apoptotic effect of estradiol in breast_cancer cells .
10072209	0	estradiol	61,70	Sex_hormone_binding_globulin	0,28	estradiol	Sex hormone binding globulin	MESH:D004958	6462	Chemical	Gene	uptake|nmod|START_ENTITY inhibits|dobj|uptake inhibits|nsubj|END_ENTITY	Sex_hormone_binding_globulin inhibits strongly the uptake of estradiol by human breast_carcinoma cells via a deprivative mechanism .
22266855	0	estradiol	28,37	Src	50,53	estradiol	Src	MESH:D004958	6714	Chemical	Gene	receptor|amod|START_ENTITY receptor|nmod|END_ENTITY	Tyrosine phosphorylation of estradiol receptor by Src regulates its hormone-dependent nuclear export and cell cycle progression in breast_cancer cells .
12586845	0	estradiol	109,118	Stromal_cell-derived_factor_1	0,29	estradiol	Stromal cell-derived factor 1	MESH:D004958	6387	Chemical	Gene	effects|nmod|START_ENTITY mediates|dobj|effects mediates|nsubj|END_ENTITY	Stromal_cell-derived_factor_1 , a novel target of estrogen_receptor action , mediates the mitogenic effects of estradiol in ovarian_and_breast_cancer cells .
19417223	0	estradiol	23,32	Urocortin_2	0,11	estradiol	Urocortin 2	MESH:D004958	90226	Chemical	Gene	secretion|amod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Urocortin_2 stimulates estradiol secretion from cultured human placental cells : an effect mediated by the type 2 corticotrophin-releasing hormone -LRB- CRH -RRB- receptor .
16394178	0	estradiol	82,91	VEGF	100,104	estradiol	VEGF	MESH:D004958	7422	Chemical	Gene	Flk-1|nmod|START_ENTITY Flk-1|nmod|END_ENTITY	Regulation of the vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor Flk-1 / KDR by estradiol through VEGF in uterus .
16394178	0	estradiol	82,91	VEGF	54,58	estradiol	VEGF	MESH:D004958	7422	Chemical	Gene	Flk-1|nmod|START_ENTITY Flk-1|nsubj|Regulation Regulation|nmod|receptor receptor|appos|END_ENTITY	Regulation of the vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor Flk-1 / KDR by estradiol through VEGF in uterus .
17356124	5	estradiol	804,813	VEGF	798,802	estradiol	VEGF	MESH:D004958	7422	Chemical	Gene	measured|nsubjpass|START_ENTITY measured|ccomp|cultured cultured|nmod|concentrations concentrations|nmod|END_ENTITY	PBMC were cultured for 48 h. Plasma and/or medium concentrations of VEGF , estradiol and progesterone were measured using enzyme-linked immunosorbent assay and radioimmunoassay kits .
19148513	8	estradiol	1302,1311	VEGF	1347,1351	estradiol	VEGF	MESH:D004958	7422	Chemical	Gene	START_ENTITY|nmod|induction induction|nmod|END_ENTITY	When the Efp expression was suppressed by siRNA , the cell growth was decreased with estradiol treatment , and other actions of estradiol and tamoxifen such as induction of VEGF were decreased .
11045935	0	estradiol	76,85	Vascular_endothelial_growth_factor	0,34	estradiol	Vascular endothelial growth factor	MESH:D004958	7422	Chemical	Gene	modulated|nmod|START_ENTITY modulated|nsubjpass|END_ENTITY	Vascular_endothelial_growth_factor is modulated in vascular muscle cells by estradiol , tamoxifen , and hypoxia .
8626126	0	estradiol	66,75	Vascular_endothelial_growth_factor	0,34	estradiol	Vascular endothelial growth factor	MESH:D004958	22339(Tax:10090)	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	Vascular_endothelial_growth_factor expression is not regulated by estradiol or medroxyprogesterone_acetate in endometrial_carcinoma .
20056830	0	estradiol	11,20	agouti-related_protein	54,76	estradiol	agouti-related protein	MESH:D004958	698479(Tax:9544)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|nmod|END_ENTITY	Effects of estradiol on cerebrospinal fluid levels of agouti-related_protein in ovariectomized rhesus_monkeys .
70036	0	estradiol	44,53	alpha-Fetoprotein	0,17	estradiol	alpha-Fetoprotein	MESH:D004958	24177(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY component|nmod|receptor component|nsubj|END_ENTITY	alpha-Fetoprotein is not a component of the estradiol receptor of the rat uterus .
1375894	0	estradiol	51,60	alpha-fetoprotein	15,32	estradiol	alpha-fetoprotein	MESH:D004958	24177(Tax:10116)	Chemical	Gene	fraction|amod|START_ENTITY administration|nmod|fraction administration|amod|END_ENTITY	Effects of rat alpha-fetoprotein administration on estradiol free fraction , the onset of puberty , and neural and uterine nuclear estrogen receptors .
18097600	0	estradiol	79,88	alpha-fetoprotein	23,40	estradiol	alpha-fetoprotein	MESH:D004958	174	Chemical	Gene	induced|nmod|START_ENTITY proliferation|acl|induced inhibits|dobj|proliferation inhibits|nsubj|peptide peptide|acl|derived derived|nmod|END_ENTITY	A peptide derived from alpha-fetoprotein inhibits the proliferation induced by estradiol in mammary_tumor cells in culture .
20109458	0	estradiol	135,144	alpha-fetoprotein	4,21	estradiol	alpha-fetoprotein	MESH:D004958	11576(Tax:10090)	Chemical	Gene	influence|nmod|START_ENTITY differentiated|nmod|influence suggests|ccomp|differentiated suggests|nsubj|model model|amod|END_ENTITY	The alpha-fetoprotein knock-out mouse model suggests that parental behavior is sexually differentiated under the influence of prenatal estradiol .
7690723	0	estradiol	82,91	alpha-fetoprotein	15,32	estradiol	alpha-fetoprotein	MESH:D004958	174	Chemical	Gene	production|amod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Purified human alpha-fetoprotein inhibits follicle-stimulating hormone-stimulated estradiol production by porcine granulosa cells in culture .
15001551	0	estradiol	83,92	alpha2-macroglobulin	45,65	estradiol	alpha2-macroglobulin	MESH:D004958	506828(Tax:9913)	Chemical	Gene	production|amod|START_ENTITY regulation|nmod|production END_ENTITY|nmod|regulation	Evidence for autocrine or paracrine roles of alpha2-macroglobulin in regulation of estradiol production by granulosa cells and development of dominant follicles .
1375908	0	estradiol	67,76	alpha_fetoprotein	15,32	estradiol	alpha fetoprotein	MESH:D004958	174	Chemical	Gene	production|amod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Purified human alpha_fetoprotein inhibits growth factor-stimulated estradiol production by porcine granulosa cells in monolayer culture .
1764091	0	estradiol	60,69	apolipoprotein_A-I	22,40	estradiol	apolipoprotein A-I	MESH:D004958	11806(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	In vivo regulation of apolipoprotein_A-I gene expression by estradiol and testosterone occurs at the translational level in inbred strains of mice .
1797939	0	estradiol	60,69	apolipoprotein_A-I	22,40	estradiol	apolipoprotein A-I	MESH:D004958	11806(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	In vivo regulation of apolipoprotein_A-I gene expression by estradiol and testosterone occurs by different mechanisms in inbred strains of mice .
16801563	0	estradiol	19,28	arginase_II	32,43	estradiol	arginase II	MESH:D004958	100008967(Tax:9986)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Modulating role of estradiol on arginase_II expression in hyperlipidemic rabbits as an atheroprotective mechanism .
23313114	0	estradiol	94,103	bone_morphogenetic_protein_2	40,68	estradiol	bone morphogenetic protein 2	MESH:D004958	615037(Tax:9913)	Chemical	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	Stage-specific expression and effect of bone_morphogenetic_protein_2 on bovine granulosa cell estradiol production : regulation by cocaine and amphetamine regulated transcript .
12842309	0	estradiol	13,22	brain-derived_neurotrophic_factor	64,97	estradiol	brain-derived neurotrophic factor	MESH:D004958	24225(Tax:10116)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|expression expression|amod|END_ENTITY	Influence of estradiol , stress , and 5-HT2A agonist treatment on brain-derived_neurotrophic_factor expression in female rats .
18309631	0	estradiol	81,90	c-Fos	72,77	estradiol	c-Fos	MESH:D004958	314322(Tax:10116)	Chemical	Gene	transduction|amod|START_ENTITY END_ENTITY|nmod|transduction	-LSB- Effect of mitogen-activated protein kinases and transcriptional factor c-Fos on estradiol signal transduction in the rat adrenocorticocytes -RSB- .
18761364	0	estradiol	8,17	c-Fos	58,63	estradiol	c-Fos	MESH:D004958	314322(Tax:10116)	Chemical	Gene	modulation|amod|START_ENTITY Lack|nmod|modulation Lack|nmod|END_ENTITY	Lack of estradiol modulation of sleep_deprivation-induced c-Fos in the rat brain .
20553875	0	estradiol	119,128	c-Fos	0,5	estradiol	c-Fos	MESH:D004958	314322(Tax:10116)	Chemical	Gene	modulated|nmod|START_ENTITY modulated|nsubjpass|induction induction|amod|END_ENTITY	c-Fos induction by a 14 T magnetic field in visceral and vestibular relays of the female rat brainstem is modulated by estradiol .
1805451	0	estradiol	15,24	c-fos	54,59	estradiol	c-fos	MESH:D004958	14281(Tax:10090)	Chemical	Gene	region|amod|START_ENTITY Presence|nmod|region Presence|nmod|oncogene oncogene|compound|END_ENTITY	Presence of an estradiol response region in the mouse c-fos oncogene .
18976678	0	estradiol	58,67	c-fos	75,80	estradiol	c-fos	MESH:D004958	314322(Tax:10116)	Chemical	Gene	alters|amod|START_ENTITY alters|dep|induction induction|amod|END_ENTITY	Masculinization induced by neonatal exposure to PGE -LRB- 2 -RRB- or estradiol alters c-fos induction by estrous odors in adult rats .
8562697	0	estradiol	39,48	c-fos	20,25	estradiol	c-fos	MESH:D004958	314322(Tax:10116)	Chemical	Gene	induction|nmod|START_ENTITY induction|nsubj|pattern pattern|nmod|END_ENTITY	Cellular pattern of c-fos induction by estradiol in the immature rat uterus .
9864735	0	estradiol	52,61	c-fos	24,29	estradiol	c-fos	MESH:D004958	2353	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|sites sites|amod|END_ENTITY	Expression of c-myc and c-fos and binding sites for estradiol and progesterone in human pituitary_tumors .
7702871	0	estradiol	10,19	c-myc	40,45	estradiol	c-myc	MESH:D004958	4609	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of estradiol and progesterone on c-myc expression in the sea star testis and the seasonal regulation of spermatogenesis .
9864735	0	estradiol	52,61	c-myc	14,19	estradiol	c-myc	MESH:D004958	4609	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|sites sites|amod|c-fos c-fos|dep|END_ENTITY	Expression of c-myc and c-fos and binding sites for estradiol and progesterone in human pituitary_tumors .
1424951	0	estradiol	21,30	calcitonin	68,78	estradiol	calcitonin	MESH:D004958	24241(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|secretion secretion|nmod|END_ENTITY	Different effects of estradiol and progesterone on the secretion of calcitonin in ovariectomized rats .
21314204	0	estradiol	76,85	caspase-8	33,42	estradiol	caspase-8	MESH:D004958	841	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nmod|effects	Involvement of caspase-9 but not caspase-8 in the anti-apoptotic effects of estradiol and 4-OH-Estradiol in MCF-7 human breast_cancer cells .
7846735	0	estradiol	10,19	cholesterol_7_alpha-hydroxylase	40,71	estradiol	cholesterol 7 alpha-hydroxylase	MESH:D004958	25428(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	Effect of estradiol and progesterone on cholesterol_7_alpha-hydroxylase activity in rats subjected to different feeding conditions .
10352122	0	estradiol	10,19	choline_acetyltransferase	46,71	estradiol	choline acetyltransferase	MESH:D004958	290567(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY phytoestrogens|nsubj|Effect phytoestrogens|nmod|mRNAs mRNAs|compound|END_ENTITY	Effect of estradiol and soy phytoestrogens on choline_acetyltransferase and nerve_growth_factor mRNAs in the frontal cortex and hippocampus of female rats .
3401777	0	estradiol	11,20	choline_acetyltransferase	42,67	estradiol	choline acetyltransferase	MESH:D004958	290567(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|amod|END_ENTITY	Effects of estradiol and dexamethasone on choline_acetyltransferase activity in various rat brain regions .
21768169	0	estradiol	18,27	constitutive_androstane_receptor	75,107	estradiol	constitutive androstane receptor	MESH:D004958	12355(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Potential role of estradiol and progesterone in insulin resistance through constitutive_androstane_receptor .
6288142	0	estradiol	62,71	cyclic_nucleotide_phosphodiesterase	9,44	estradiol	cyclic nucleotide phosphodiesterase	MESH:D004958	50678(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY Role|nmod|effect Role|nmod|END_ENTITY	-LSB- Role of cyclic_nucleotide_phosphodiesterase in the effect of estradiol on uterine tissue -RSB- .
18196959	0	estradiol	11,20	cyclin_D1	94,103	estradiol	cyclin D1	MESH:D004958	595	Chemical	Gene	Effects|nmod|START_ENTITY proteins|nsubj|Effects proteins|dobj|END_ENTITY	Effects of estradiol and medroxyprogesterone_acetate on expression of the cell cycle proteins cyclin_D1 , p21 and p27 in cultured human_breast_tissues .
9683804	0	estradiol	24,33	cyclin_D1	53,62	estradiol	cyclin D1	MESH:D004958	595	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Differential effects of estradiol and its analogs on cyclin_D1 and CDK4 expression in estrogen receptor positive MCF-7 and estrogen receptor-transfected MCF-10AEwt5 cells .
3660441	0	estradiol	73,82	cytochrome_P-450	18,34	estradiol	cytochrome P-450	MESH:D004958	25251(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|properties properties|nmod|END_ENTITY	The properties of cytochrome_P-450 induced in the rat small intestine by estradiol .
15817670	0	estradiol	48,57	cytochrome_P450_3A4	25,44	estradiol	cytochrome P450 3A4	MESH:D004958	1576	Chemical	Gene	homeostasis|amod|START_ENTITY role|nmod|homeostasis role|nmod|END_ENTITY	Potential role for human cytochrome_P450_3A4 in estradiol homeostasis .
2209924	0	estradiol	50,59	epidermal_growth_factor	15,38	estradiol	epidermal growth factor	MESH:D004958	1950	Chemical	Gene	-LSB-|nmod|START_ENTITY -LSB-|dobj|effect effect|nmod|END_ENTITY	-LSB- The effect of epidermal_growth_factor -LRB- EGF -RRB- with estradiol and progesterone on prolactin secretion from cultured human decidual tissues of early pregnancy -RSB- .
2786982	0	estradiol	92,101	epidermal_growth_factor	6,29	estradiol	epidermal growth factor	MESH:D004958	13645(Tax:10090)	Chemical	Gene	altered|nmod|START_ENTITY altered|nsubjpass|concentrations concentrations|compound|END_ENTITY	Mouse epidermal_growth_factor concentrations are altered by gonadectomy and treatments with estradiol and progesterone .
2787270	0	estradiol	11,20	epidermal_growth_factor	41,64	estradiol	epidermal growth factor	MESH:D004958	13645(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|concentration concentration|compound|END_ENTITY	Effects of estradiol and progesterone on epidermal_growth_factor concentration in plasma , bile , urine , submandibular gland and kidney of the mouse .
7654008	0	estradiol	21,30	epidermal_growth_factor	67,90	estradiol	epidermal growth factor	MESH:D004958	1950	Chemical	Gene	progesterone|amod|START_ENTITY END_ENTITY|compound|progesterone	Growth regulation by estradiol , progesterone and recombinant human epidermal_growth_factor of human breast_carcinoma xenografts grown serially in nude_mice .
7737543	0	estradiol	14,23	epidermal_growth_factor	75,98	estradiol	epidermal growth factor	MESH:D004958	1950	Chemical	Gene	cells|amod|START_ENTITY cells|nmod|influence influence|nmod|END_ENTITY	-LSB- Synthesis of estradiol by endometrial stroma cells under the influence of epidermal_growth_factor -LRB- EGF -RRB- in vitro -RSB- .
84755	0	estradiol	68,77	estrogen-binding_protein	18,42	estradiol	estrogen-binding protein	MESH:D004958	117278(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of the serum estrogen-binding_protein in the control of tissue estradiol levels during postnatal development of the female rat .
12586845	0	estradiol	109,118	estrogen_receptor	49,66	estradiol	estrogen receptor	MESH:D004958	2099	Chemical	Gene	effects|nmod|START_ENTITY mediates|dobj|effects mediates|nsubj|Stromal_cell-derived_factor_1 Stromal_cell-derived_factor_1|appos|target target|nmod|action action|compound|END_ENTITY	Stromal_cell-derived_factor_1 , a novel target of estrogen_receptor action , mediates the mitogenic effects of estradiol in ovarian_and_breast_cancer cells .
12732290	0	estradiol	15,24	estrogen_receptor	39,56	estradiol	estrogen receptor	MESH:D004958	2099	Chemical	Gene	modulators|amod|START_ENTITY modulators|compound|END_ENTITY	The effects of estradiol and selective estrogen_receptor modulators on gene expression and messenger RNA stability in immortalized sheep endometrial stromal cells and human endometrial_adenocarcinoma cells .
1306521	0	estradiol	93,102	estrogen_receptor	51,68	estradiol	estrogen receptor	MESH:D004958	2099	Chemical	Gene	cases|amod|START_ENTITY explain|dobj|cases explain|nsubj|initiation initiation|nmod|translation translation|nmod|mRNA mRNA|compound|END_ENTITY	Differential initiation of translation of a single estrogen_receptor mRNA could explain some estradiol resistance cases .
15094777	0	estradiol	72,81	estrogen_receptor	132,149	estradiol	estrogen receptor	MESH:D004958	2099	Chemical	Gene	transactivation|amod|START_ENTITY transactivation|nmod|END_ENTITY	Inhibition of tumor-associated fatty_acid_synthase activity antagonizes estradiol - and tamoxifen-induced agonist transactivation of estrogen_receptor -LRB- ER -RRB- in human endometrial_adenocarcinoma cells .
17897069	0	estradiol	128,137	estrogen_receptor	142,159	estradiol	estrogen receptor	MESH:D004958	2099	Chemical	Gene	2,2-dimethyl-benzopyrans|nmod|START_ENTITY Synthesis|amod|2,2-dimethyl-benzopyrans Synthesis|nmod|ligands ligands|compound|END_ENTITY	Synthesis of 3-phenyl-4-phenylvinyl_benzopyranones and the corresponding 2,2-dimethyl-benzopyrans with structural similarity to estradiol , as estrogen_receptor ligands .
1911426	0	estradiol	32,41	estrogen_receptor	72,89	estradiol	estrogen receptor	MESH:D004958	2099	Chemical	Gene	derivatives|nmod|START_ENTITY ligands|nsubj|derivatives ligands|nmod|END_ENTITY	Methyl and bromo derivatives of estradiol are agonistic ligands for the estrogen_receptor of MCF-7 breast_cancer cells .
19167882	0	estradiol	15,24	estrogen_receptor	103,120	estradiol	estrogen receptor	MESH:D004958	2099	Chemical	Gene	START_ENTITY|dep|generates generates|dobj|compounds compounds|acl:relcl|agonists agonists|compound|END_ENTITY	Deconstructing estradiol : removal of B-ring generates compounds which are potent and subtype-selective estrogen_receptor agonists .
2039526	0	estradiol	75,84	estrogen_receptor	46,63	estradiol	estrogen receptor	MESH:D004958	2099	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|dep|effect	BALB/C mouse 3T3 fibroblasts expressing human estrogen_receptor : effect of estradiol on cell growth .
20547157	0	estradiol	73,82	estrogen_receptor	131,148	estradiol	estrogen receptor	MESH:D004958	2099	Chemical	Gene	activity|amod|START_ENTITY molecules|nmod|activity identification|nmod|molecules identification|acl|inactivate inactivate|dobj|END_ENTITY	Schistosoma_haematobium : identification of new estrogenic molecules with estradiol antagonistic activity and ability to inactivate estrogen_receptor in mammalian cells .
22326682	0	estradiol	58,67	estrogen_receptor	94,111	estradiol	estrogen receptor	MESH:D004958	2099	Chemical	Gene	derivatives|nmod|START_ENTITY substituents|nmod|derivatives determine|nsubj|substituents determine|dobj|modulator modulator|compound|END_ENTITY	The terminal substituents of 7a , 6-hexanyl derivatives of estradiol determine their selective estrogen_receptor modulator versus agonist activities .
3216858	0	estradiol	54,63	estrogen_receptor	18,35	estradiol	estrogen receptor	MESH:D004958	2099	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of the estrogen_receptor in MCF-7 cells by estradiol .
3747518	0	estradiol	21,30	estrogen_receptor	53,70	estradiol	estrogen receptor	MESH:D004958	2099	Chemical	Gene	interactions|amod|START_ENTITY modeling|nmod|interactions modeling|nmod|END_ENTITY	Computer modeling of estradiol interactions with the estrogen_receptor .
3840166	0	estradiol	58,67	estrogen_receptor	18,35	estradiol	estrogen receptor	MESH:D004958	2099	Chemical	Gene	affinity|nmod|START_ENTITY affinity|nsubj|Modulation Modulation|nmod|END_ENTITY	Modulation of the estrogen_receptor 's affinity for DNA by estradiol .
6705734	0	estradiol	34,43	estrogen_receptor	53,70	estradiol	estrogen receptor	MESH:D004958	2099	Chemical	Gene	C-17_esters|nmod|START_ENTITY interaction|nmod|C-17_esters interaction|nmod|END_ENTITY	The interaction of C-17_esters of estradiol with the estrogen_receptor .
6724054	0	estradiol	67,76	estrogen_receptor	114,131	estradiol	estrogen receptor	MESH:D004958	2099	Chemical	Gene	using|dobj|START_ENTITY using|nmod|purification purification|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- The marginal utility of affinity chromatography using immobilized estradiol in the purification of human uterine estrogen_receptor -RSB- .
7060523	0	estradiol	109,118	estrogen_receptor	51,68	estradiol	estrogen receptor	MESH:D004958	2099	Chemical	Gene	activation|acl|START_ENTITY activation|amod|END_ENTITY	Estrogen_receptor in avian embryo and adult liver : estrogen_receptor activation and dissociation kinetics of estradiol , ethynylestradiol , and moxestrol .
7074937	0	estradiol	77,86	estrogen_receptor	18,35	estradiol	estrogen receptor	MESH:D004958	2099	Chemical	Gene	use|nmod|START_ENTITY micro-assay|nmod|use micro-assay|nmod|END_ENTITY	A micro-assay for estrogen_receptor in breast_tumor with use of 125I-labeled estradiol .
8276133	0	estradiol	57,66	estrogen_receptor	31,48	estradiol	estrogen receptor	MESH:D004958	100136026(Tax:8022)	Chemical	Gene	hypothalamus|amod|START_ENTITY regulation|nmod|hypothalamus regulation|nmod|mRNA mRNA|compound|END_ENTITY	Differential regulation of the estrogen_receptor mRNA by estradiol in the trout hypothalamus and pituitary .
9328205	0	estradiol	5,14	estrogen_receptor	112,129	estradiol	estrogen receptor	MESH:D004958	2099	Chemical	Gene	proliferation|amod|START_ENTITY transfected|nsubj|proliferation transfected|nmod|END_ENTITY	Both estradiol and tamoxifen decrease proliferation and invasiveness of cancer cells transfected with a mutated estrogen_receptor .
9375357	0	estradiol	74,83	estrogen_receptor	17,34	estradiol	estrogen receptor	MESH:D004958	100136026(Tax:8022)	Chemical	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	Up-regulation of estrogen_receptor mRNA and estrogen_receptor activity by estradiol in liver of rainbow_trout and other teleostean fish .
9497106	0	estradiol	192,201	estrogen_receptor	113,130	estradiol	estrogen receptor	MESH:D004958	2099	Chemical	Gene	role|nmod|START_ENTITY mechanism|nmod|role Induction|dep|mechanism Induction|nmod|p21 p21|acl|transfected transfected|nmod|gene gene|compound|END_ENTITY	Induction of p21 -LRB- CIP1/WAF1/SID1 -RRB- by estradiol in a breast epithelial cell line transfected with the recombinant estrogen_receptor gene : a possible mechanism for a negative regulatory role of estradiol .
9497106	0	estradiol	37,46	estrogen_receptor	113,130	estradiol	estrogen receptor	MESH:D004958	2099	Chemical	Gene	line|amod|START_ENTITY p21|nmod|line p21|acl|transfected transfected|nmod|gene gene|compound|END_ENTITY	Induction of p21 -LRB- CIP1/WAF1/SID1 -RRB- by estradiol in a breast epithelial cell line transfected with the recombinant estrogen_receptor gene : a possible mechanism for a negative regulatory role of estradiol .
9605407	0	estradiol	118,127	estrogen_receptor	28,45	estradiol	estrogen receptor	MESH:D004958	2099	Chemical	Gene	identifies|ccomp|START_ENTITY identifies|nsubj|mutagenesis mutagenesis|nmod|ligand_binding_domain ligand_binding_domain|compound|END_ENTITY	Random mutagenesis of human estrogen_receptor ligand_binding_domain identifies mutations that decrease sensitivity to estradiol and increase sensitivity to a diphenol_indene-ol compound : basis for a regulatable expression system .
23225083	0	estradiol	83,92	estrogen_receptor-a	44,63	estradiol	estrogen receptor-a	MESH:D004958	13982(Tax:10090)	Chemical	Gene	modulators|amod|START_ENTITY effects|nmod|modulators END_ENTITY|nmod|effects	The role of activation functions 1 and 2 of estrogen_receptor-a for the effects of estradiol and selective estrogen receptor modulators in male mice .
11823467	0	estradiol	139,148	estrogen_receptor-alpha	93,116	estradiol	estrogen receptor-alpha	MESH:D004958	2099	Chemical	Gene	alter|advcl|START_ENTITY alter|nsubj|Mutations Mutations|acl|targeted targeted|nmod|helix helix|nmod|region region|nmod|END_ENTITY	Mutations targeted to a predicted helix in the extreme carboxyl-terminal region of the human estrogen_receptor-alpha alter its response to estradiol and 4-hydroxytamoxifen .
11914066	0	estradiol	109,118	estrogen_receptor-alpha	39,62	estradiol	estrogen receptor-alpha	MESH:D004958	2099	Chemical	Gene	affinity|nmod|START_ENTITY alter|dobj|affinity alter|nsubj|Mutations Mutations|nmod|537 537|nmod|END_ENTITY	Mutations of tyrosine 537 in the human estrogen_receptor-alpha selectively alter the receptor 's affinity for estradiol and the kinetics of the interaction .
12646062	0	estradiol	151,160	estrogen_receptor-alpha	31,54	estradiol	estrogen receptor-alpha	MESH:D004958	2099	Chemical	Gene	differentiation|nmod|START_ENTITY Expression|acl|differentiation Expression|nmod|protein protein|amod|END_ENTITY	Expression and localization of estrogen_receptor-alpha protein in normal and abnormal term placentae and stimulation of trophoblast differentiation by estradiol .
12970748	0	estradiol	10,19	estrogen_receptor-alpha	23,46	estradiol	estrogen receptor-alpha	MESH:D004958	2099	Chemical	Gene	START_ENTITY|nmod|gene gene|amod|END_ENTITY	Effect of estradiol on estrogen_receptor-alpha gene expression and activity can be modulated by the ErbB2/PI _ 3-K/Akt pathway .
17065413	0	estradiol	24,33	estrogen_receptor-alpha	106,129	estradiol	estrogen receptor-alpha	MESH:D004958	13982(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY dependent|nsubj|effects dependent|nmod|END_ENTITY	The bi-modal effects of estradiol on gonadotropin synthesis and secretion in female mice are dependent on estrogen_receptor-alpha .
17356055	0	estradiol	14,23	estrogen_receptor-alpha	77,100	estradiol	estrogen receptor-alpha	MESH:D004958	2099	Chemical	Gene	impact|nmod|START_ENTITY modulated|nsubjpass|impact modulated|nmod|polymorphism polymorphism|amod|END_ENTITY	The impact of estradiol on bone_mineral_density is modulated by the specific estrogen_receptor-alpha cofactor retinoblastoma-interacting zinc finger protein-1 insertion/deletion polymorphism .
21788522	0	estradiol	102,111	estrogen_receptor-alpha	31,54	estradiol	estrogen receptor-alpha	MESH:D004958	13982(Tax:10090)	Chemical	Gene	action|nmod|START_ENTITY required|nmod|action required|nsubjpass|2 2|nmod|END_ENTITY	Activation function 2 -LRB- AF2 -RRB- of estrogen_receptor-alpha is required for the atheroprotective action of estradiol but not to accelerate endothelial healing .
9801392	0	estradiol	36,45	estrogen_receptor-alpha	66,89	estradiol	estrogen receptor-alpha	MESH:D004958	13982(Tax:10090)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|forebrain forebrain|nmod|mice mice|amod|END_ENTITY	Induction of progestin receptors by estradiol in the forebrain of estrogen_receptor-alpha gene-disrupted mice .
11286288	0	estradiol	77,86	estrogen_receptor_alpha	50,73	estradiol	estrogen receptor alpha	MESH:D004958	443228(Tax:9940)	Chemical	Gene	study|nmod|START_ENTITY study|nmod|regulation regulation|nmod|END_ENTITY	An immunohistochemical study on the regulation of estrogen_receptor_alpha by estradiol in the endometrium of the immature ewe .
11714653	0	estradiol	157,166	fas_ligand	132,142	estradiol	fas ligand	MESH:D004958	356	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Estrogen_receptor-mediated , nitric_oxide-dependent modulation of the immunologic barrier function of the endothelium : regulation of fas_ligand expression by estradiol .
15073041	0	estradiol	61,70	fibroblast_growth_factor-2	8,34	estradiol	fibroblast growth factor-2	MESH:D004958	14173(Tax:10090)	Chemical	Gene	migration|amod|START_ENTITY effect|nmod|migration Role|nmod|effect Role|nmod|isoforms isoforms|amod|END_ENTITY	Role of fibroblast_growth_factor-2 isoforms in the effect of estradiol on endothelial cell migration and proliferation .
17071606	0	estradiol	74,83	fibroblast_growth_factor-2	30,56	estradiol	fibroblast growth factor-2	MESH:D004958	14173(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nmod|effect	Essential role of bone marrow fibroblast_growth_factor-2 in the effect of estradiol on reendothelialization and endothelial progenitor cell mobilization .
9879983	0	estradiol	66,75	focal_adhesion_kinase	38,59	estradiol	focal adhesion kinase	MESH:D004958	5747	Chemical	Gene	treatment|amod|START_ENTITY END_ENTITY|nmod|treatment	Decreased tyrosine phosphorylation of focal_adhesion_kinase after estradiol treatment of MCF-7 human breast_carcinoma cells .
9645694	0	estradiol	77,86	glial_fibrillary_acidic_protein	42,73	estradiol	glial fibrillary acidic protein	MESH:D004958	24387(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Bidirectional transcription regulation of glial_fibrillary_acidic_protein by estradiol in vivo and in vitro .
22183707	0	estradiol	36,45	glycogen_synthase_kinase-3b	115,142	estradiol	glycogen synthase kinase-3b	MESH:D004958	84027(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effect of chronic administration of estradiol , progesterone , and tibolone on the expression and phosphorylation of glycogen_synthase_kinase-3b and the microtubule-associated_protein_tau in the hippocampus and cerebellum of female rat .
11095431	0	estradiol	145,154	gonadotropin-releasing_hormone	81,111	estradiol	gonadotropin-releasing hormone	MESH:D004958	2796	Chemical	Gene	inhibition|nmod|START_ENTITY flutamide|xcomp|inhibition flutamide|dobj|sensitivity sensitivity|nmod|generator generator|amod|END_ENTITY	Polycystic_ovarian_syndrome : evidence that flutamide restores sensitivity of the gonadotropin-releasing_hormone pulse generator to inhibition by estradiol and progesterone .
12168736	0	estradiol	6,15	gonadotropin-releasing_hormone	145,175	estradiol	gonadotropin-releasing hormone	MESH:D004958	2796	Chemical	Gene	level|dep|START_ENTITY Day|amod|level predicts|nsubj|Day predicts|nmod|patients patients|acl|undergoing undergoing|advcl|using using|dobj|regimen regimen|amod|END_ENTITY	Day 6 estradiol level predicts cycle cancellation among poor responder patients undergoing in vitro fertilization-embryo transfer cycles using a gonadotropin-releasing_hormone agonist flare regimen .
12890720	0	estradiol	76,85	gonadotropin-releasing_hormone	34,64	estradiol	gonadotropin-releasing hormone	MESH:D004958	2796	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|neurons neurons|amod|END_ENTITY	Direct and indirect regulation of gonadotropin-releasing_hormone neurons by estradiol .
15564326	0	estradiol	103,112	gonadotropin-releasing_hormone	20,50	estradiol	gonadotropin-releasing hormone	MESH:D004958	2796	Chemical	Gene	receptor-alpha|amod|START_ENTITY levels|nmod|receptor-alpha changing|nmod|levels changing|dobj|frequency frequency|amod|END_ENTITY	Effects of changing gonadotropin-releasing_hormone pulse frequency and estrogen treatment on levels of estradiol receptor-alpha and induction of Fos and phosphorylated_cyclic_adenosine_monophosphate response element binding protein in pituitary gonadotropes : studies in hypothalamo-pituitary disconnected ewes .
15623811	0	estradiol	71,80	gonadotropin-releasing_hormone	92,122	estradiol	gonadotropin-releasing hormone	MESH:D004958	2796	Chemical	Gene	START_ENTITY|nmod|women women|amod|END_ENTITY	A randomized placebo-controlled trial of short-term graded transdermal estradiol in healthy gonadotropin-releasing_hormone agonist-suppressed pre - and postmenopausal women : effects on serum markers of bone_turnover , insulin-like growth factor-I , and osteoclastogenic mediators .
17244784	0	estradiol	45,54	gonadotropin-releasing_hormone	107,137	estradiol	gonadotropin-releasing hormone	MESH:D004958	2796	Chemical	Gene	levels|compound|START_ENTITY enhances|dobj|levels enhances|nmod|women women|acl|receiving receiving|dobj|therapy therapy|amod|END_ENTITY	Increased adiposity enhances intrafollicular estradiol levels in normoandrogenic ovulatory women receiving gonadotropin-releasing_hormone analog/recombinant human follicle-stimulating hormone therapy for in vitro fertilization .
17596564	0	estradiol	122,131	gonadotropin-releasing_hormone	20,50	estradiol	gonadotropin-releasing hormone	MESH:D004958	2796	Chemical	Gene	rats|nmod|START_ENTITY maturation|nmod|rats maturation|nmod|secretion secretion|amod|END_ENTITY	Early maturation of gonadotropin-releasing_hormone secretion and sexual_precocity after exposure of infant female rats to estradiol or dichlorodiphenyltrichloroethane .
18675961	0	estradiol	21,30	gonadotropin-releasing_hormone	153,183	estradiol	gonadotropin-releasing hormone	MESH:D004958	2796	Chemical	Gene	patch|amod|START_ENTITY Comparison|nmod|patch suppression|nsubj|Comparison suppression|nmod|stimulation stimulation|nmod|protocol protocol|amod|END_ENTITY	Comparison of luteal estradiol patch and gonadotropin-releasing_hormone antagonist suppression protocol before gonadotropin stimulation versus microdose gonadotropin-releasing_hormone agonist protocol for patients with a history of poor in vitro fertilization outcomes .
19200978	0	estradiol	191,200	gonadotropin-releasing_hormone	26,56	estradiol	gonadotropin-releasing hormone	MESH:D004958	2796	Chemical	Gene	levels|compound|START_ENTITY cause|nmod|levels cause|csubj|Triggering Triggering|nmod|agonist agonist|amod|END_ENTITY	Triggering ovulation with gonadotropin-releasing_hormone agonist in in vitro fertilization patients with polycystic_ovaries does not cause ovarian_hyperstimulation syndrome despite very high estradiol levels .
19398092	0	estradiol	33,42	gonadotropin-releasing_hormone	74,104	estradiol	gonadotropin-releasing hormone	MESH:D004958	2796	Chemical	Gene	Evaluation|nmod|START_ENTITY Evaluation|nmod|treatment treatment|amod|END_ENTITY	Evaluation of different add-back estradiol and progesterone treatments to gonadotropin-releasing_hormone agonist treatment in patients with premenstrual_dysphoric_disorder .
19403828	0	estradiol	117,126	gonadotropin-releasing_hormone	27,57	estradiol	gonadotropin-releasing hormone	MESH:D004958	14714(Tax:10090)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Differential regulation of gonadotropin-releasing_hormone neuron activity and membrane properties by acutely applied estradiol : dependence on dose and estrogen receptor subtype .
19438162	0	estradiol	31,40	gonadotropin-releasing_hormone	52,82	estradiol	gonadotropin-releasing hormone	MESH:D004958	2796	Chemical	Gene	Predictors|nmod|START_ENTITY rise|nsubj|Predictors rise|nmod|initiation initiation|amod|END_ENTITY	Predictors and implications of estradiol rise after gonadotropin-releasing_hormone antagonist initiation during in vitro fertilization cycles .
21868004	0	estradiol	184,193	gonadotropin-releasing_hormone	74,104	estradiol	gonadotropin-releasing hormone	MESH:D004958	2796	Chemical	Gene	impact|amod|START_ENTITY does|nmod|impact does|csubj|Programming Programming|advcl|working working|nmod|protocol protocol|amod|END_ENTITY	Programming in vitro fertilization retrievals during working days after a gonadotropin-releasing_hormone antagonist protocol with estrogen pretreatment : does the length of exposure to estradiol impact on controlled ovarian_hyperstimulation outcomes ?
22332446	0	estradiol	57,66	gonadotropin-releasing_hormone	178,208	estradiol	gonadotropin-releasing hormone	MESH:D004958	2796	Chemical	Gene	levels|amod|START_ENTITY circulating|dobj|levels increase|acl|circulating oocytes|nmod|increase yield|nmod|oocytes treated|nsubj|yield treated|nmod|hormone hormone|nmod|protocols protocols|amod|END_ENTITY	High yield of oocytes without an increase in circulating estradiol levels in breast_cancer patients treated with follicle-stimulating hormone and aromatase inhibitor in standard gonadotropin-releasing_hormone analogue protocols .
23978477	0	estradiol	25,34	gonadotropin-releasing_hormone	97,127	estradiol	gonadotropin-releasing hormone	MESH:D004958	2796	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|neurons neurons|amod|END_ENTITY	Non-classical effects of estradiol on cAMP responsive element binding protein phosphorylation in gonadotropin-releasing_hormone neurons : mechanisms and role .
24179871	0	estradiol	7,16	gonadotropin-releasing_hormone	36,66	estradiol	gonadotropin-releasing hormone	MESH:D004958	2796	Chemical	Gene	supplementation|amod|START_ENTITY supplementation|nmod|cycles cycles|amod|END_ENTITY	Luteal estradiol supplementation in gonadotropin-releasing_hormone antagonist cycles for infertile patients in vitro fertilization .
2680619	0	estradiol	167,176	gonadotropin-releasing_hormone	114,144	estradiol	gonadotropin-releasing hormone	MESH:D004958	2796	Chemical	Gene	agonist|amod|START_ENTITY agonist|amod|END_ENTITY	Transfer of cryopreserved-thawed embryos : the natural cycle versus controlled preparation of the endometrium with gonadotropin-releasing_hormone agonist and exogenous estradiol and progesterone -LRB- GEEP -RRB- .
3317420	0	estradiol	107,116	gonadotropin-releasing_hormone	41,71	estradiol	gonadotropin-releasing hormone	MESH:D004958	613033(Tax:9544)	Chemical	Gene	inputs|amod|START_ENTITY generator|nmod|inputs generator|amod|END_ENTITY	Unexpected responses of the hypothalamic gonadotropin-releasing_hormone `` pulse generator '' to physiological estradiol inputs in the absence of the ovary .
3530378	0	estradiol	11,20	gonadotropin-releasing_hormone	45,75	estradiol	gonadotropin-releasing hormone	MESH:D004958	2796	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of estradiol and progesterone on the gonadotropin-releasing_hormone -LRB- GnRH -RRB- - immunoreactive neuronal system of the anestrous ewe .
3904849	0	estradiol	30,39	gonadotropin-releasing_hormone	139,169	estradiol	gonadotropin-releasing hormone	MESH:D004958	2796	Chemical	Gene	feedback|amod|START_ENTITY prevent|nmod|feedback prevent|nmod|ewes ewes|nmod|frequency frequency|amod|END_ENTITY	Does the seasonal increase in estradiol negative feedback prevent luteinizing hormone surges in anestrous ewes by suppressing hypothalamic gonadotropin-releasing_hormone pulse frequency ?
6800257	0	estradiol	56,65	gonadotropin-releasing_hormone	14,44	estradiol	gonadotropin-releasing hormone	MESH:D004958	2796	Chemical	Gene	secretion|amod|START_ENTITY effect|nmod|secretion effect|nmod|END_ENTITY	The effect of gonadotropin-releasing_hormone on ovarian estradiol secretion .
6808293	0	estradiol	19,28	gonadotropin-releasing_hormone	64,94	estradiol	gonadotropin-releasing hormone	MESH:D004958	2796	Chemical	Gene	effect|nmod|START_ENTITY effect|acl|END_ENTITY	Biphasic effect of estradiol on luteinizing hormone response to gonadotropin-releasing_hormone in castrated men .
7588302	0	estradiol	5,14	gonadotropin-releasing_hormone	39,69	estradiol	gonadotropin-releasing hormone	MESH:D004958	443529(Tax:9940)	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|surge surge|amod|END_ENTITY	Does estradiol induce the preovulatory gonadotropin-releasing_hormone -LRB- GnRH -RRB- surge in the ewe by inducing a progressive change in the mode of operation of the GnRH neurosecretory system .
767161	0	estradiol	6,15	gonadotropin-releasing_hormone	28,58	estradiol	gonadotropin-releasing hormone	MESH:D004958	2796	Chemical	Gene	response|amod|START_ENTITY response|acl|END_ENTITY	Serum estradiol response to gonadotropin-releasing_hormone : studies in normal women and in women with secondary amenorrhea .
8137746	0	estradiol	83,92	gonadotropin-releasing_hormone	32,62	estradiol	gonadotropin-releasing hormone	MESH:D004958	2796	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|regulation regulation|nmod|END_ENTITY	Central regulation of pulsatile gonadotropin-releasing_hormone -LRB- GnRH -RRB- secretion by estradiol during the period leading up to the preovulatory GnRH surge in the ewe .
8286620	0	estradiol	131,140	gonadotropin-releasing_hormone	20,50	estradiol	gonadotropin-releasing hormone	MESH:D004958	2796	Chemical	Gene	action|nmod|START_ENTITY response|nmod|action alteration|nmod|response changes|dep|alteration changes|nmod|secretion secretion|amod|END_ENTITY	Seasonal changes in gonadotropin-releasing_hormone secretion in the ewe : alteration in response to the negative feedback action of estradiol .
9389526	0	estradiol	148,157	gonadotropin-releasing_hormone	60,90	estradiol	gonadotropin-releasing hormone	MESH:D004958	2796	Chemical	Gene	signal|amod|START_ENTITY processing|nmod|signal implications|nmod|processing requirements|dep|implications requirements|nmod|surge surge|amod|END_ENTITY	Estradiol requirements for induction and maintenance of the gonadotropin-releasing_hormone surge : implications for neuroendocrine processing of the estradiol signal .
9467578	0	estradiol	131,140	gonadotropin-releasing_hormone	67,97	estradiol	gonadotropin-releasing hormone	MESH:D004958	2796	Chemical	Gene	inhibition|nmod|START_ENTITY sensitivity|acl|inhibition sensitivity|nmod|generator generator|amod|END_ENTITY	Polycystic_ovary_syndrome : evidence for reduced sensitivity of the gonadotropin-releasing_hormone pulse generator to inhibition by estradiol and progesterone .
9758002	0	estradiol	32,41	gonadotropin-releasing_hormone	51,81	estradiol	gonadotropin-releasing hormone	MESH:D004958	2796	Chemical	Gene	START_ENTITY|nmod|agonist agonist|amod|END_ENTITY	The failed suppression of serum estradiol level by gonadotropin-releasing_hormone agonist in a case of pelvic_endometriosis .
9843641	0	estradiol	15,24	gonadotropin-releasing_hormone	28,58	estradiol	gonadotropin-releasing hormone	MESH:D004958	14714(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|neurons neurons|amod|END_ENTITY	The effects of estradiol on gonadotropin-releasing_hormone neurons in the developing mouse brain .
9886822	0	estradiol	93,102	gonadotropin-releasing_hormone	132,162	estradiol	gonadotropin-releasing hormone	MESH:D004958	2796	Chemical	Gene	effect|nmod|START_ENTITY expression|nmod|effect essential|nmod|expression essential|advcl|inducing inducing|dobj|surge surge|amod|END_ENTITY	Progesterone priming is essential for the full expression of the positive feedback effect of estradiol in inducing the preovulatory gonadotropin-releasing_hormone surge in the ewe .
10698176	0	estradiol	76,85	gonadotropin-releasing_hormone_receptor	28,67	estradiol	gonadotropin-releasing hormone receptor	MESH:D004958	14715(Tax:10090)	Chemical	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Responsiveness of the ovine gonadotropin-releasing_hormone_receptor gene to estradiol and gonadotropin-releasing_hormone is not detectable in vitro but is revealed in transgenic_mice .
21153168	0	estradiol	11,20	gonadotropin-releasing_hormone_receptor	42,81	estradiol	gonadotropin-releasing hormone receptor	MESH:D004958	2798	Chemical	Gene	START_ENTITY|nmod|concentrations concentrations|nmod|messenger messenger|amod|END_ENTITY	Effects of estradiol on concentrations of gonadotropin-releasing_hormone_receptor messenger ribonucleic_acid following removal of progesterone .
2848982	0	estradiol	110,119	gonadotropin-releasing_hormone_receptor	14,53	estradiol	gonadotropin-releasing hormone receptor	MESH:D004958	81668(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY Modulation|nmod|treatment Modulation|nmod|concentration concentration|amod|END_ENTITY	Modulation of gonadotropin-releasing_hormone_receptor concentration in cultured female rat pituitary cells by estradiol treatment .
7673072	0	estradiol	212,221	gonadotropin-releasing_hormone_receptor	31,70	estradiol	gonadotropin-releasing hormone receptor	MESH:D004958	2798	Chemical	Gene	ribonucleic_acid|nmod|START_ENTITY ribonucleic_acid|nmod|END_ENTITY	Messenger ribonucleic_acid for gonadotropin-releasing_hormone_receptor and numbers of gonadotropin-releasing_hormone_receptors in ovariectomized ewes after hypothalamic-pituitary disconnection and treatment with estradiol .
10946861	0	estradiol	5,14	growth_hormone	63,77	estradiol	growth hormone	MESH:D004958	2688	Chemical	Gene	administration|amod|START_ENTITY modulates|nsubj|administration modulates|dep|releasing releasing|nsubj|END_ENTITY	Oral estradiol administration modulates continuous intravenous growth_hormone -LRB- GH -RRB- - releasing peptide-2-driven GH secretion in postmenopausal women .
11158008	0	estradiol	11,20	growth_hormone	46,60	estradiol	growth hormone	MESH:D004958	2688	Chemical	Gene	augments|amod|START_ENTITY END_ENTITY|nsubj|augments	Short-term estradiol supplementation augments growth_hormone -LRB- GH -RRB- secretory responsiveness to dose-varying GH-releasing peptide infusions in healthy postmenopausal women .
11430712	0	estradiol	41,50	growth_hormone	117,131	estradiol	growth hormone	MESH:D004958	2688	Chemical	Gene	growth_hormone|amod|START_ENTITY administration|nmod|growth_hormone Morning|nmod|administration Morning|dep|impact impact|nmod|END_ENTITY	Morning versus evening administration of estradiol to girls with turner_syndrome receiving growth_hormone : impact on growth_hormone and metabolism .
11443179	0	estradiol	11,20	growth_hormone	127,141	estradiol	growth hormone	MESH:D004958	2688	Chemical	Gene	replacement|amod|START_ENTITY mutes|nsubj|replacement mutes|dobj|inhibition inhibition|acl|fasting fasting|dobj|secretion secretion|amod|END_ENTITY	Short-term estradiol replacement in postmenopausal women selectively mutes somatostatin 's dose-dependent inhibition of fasting growth_hormone secretion .
11967186	0	estradiol	134,143	growth_hormone	24,38	estradiol	growth hormone	MESH:D004958	2688	Chemical	Gene	receptor|amod|START_ENTITY alpha|nsubj|receptor express|xcomp|alpha express|nsubj|modulation modulation|nmod|secretion secretion|amod|END_ENTITY	Estradiol modulation of growth_hormone secretion in the ewe : no growth_hormone-releasing hormone neurons and few somatotropes express estradiol receptor alpha .
15356089	0	estradiol	145,154	growth_hormone	38,52	estradiol	growth hormone	MESH:D004958	2688	Chemical	Gene	clamp|amod|START_ENTITY studied|nmod|clamp studied|nsubj|drive drive|nmod|secretion secretion|compound|END_ENTITY	Dual secretagogue drive of burst-like growth_hormone secretion in postmenopausal compared with premenopausal women studied under an experimental estradiol clamp .
15579792	0	estradiol	37,46	growth_hormone	123,137	estradiol	growth hormone	MESH:D004958	2688	Chemical	Gene	Contributions|nmod|START_ENTITY Contributions|acl|maximal maximal|dobj|drive drive|nmod|secretion secretion|compound|END_ENTITY	Contributions of gender and systemic estradiol and testosterone concentrations to maximal secretagogue drive of burst-like growth_hormone secretion in healthy middle-aged and older adults .
15613434	0	estradiol	128,137	growth_hormone	54,68	estradiol	growth hormone	MESH:D004958	2688	Chemical	Gene	clamp|amod|START_ENTITY studied|nmod|clamp studied|nsubj|Determinants Determinants|nmod|drive drive|nmod|secretion secretion|compound|END_ENTITY	Determinants of dual secretagogue drive of burst-like growth_hormone secretion in premenopausal women studied under a selective estradiol clamp .
16189255	0	estradiol	59,68	growth_hormone	74,88	estradiol	growth hormone	MESH:D004958	2688	Chemical	Gene	START_ENTITY|nmod|therapy therapy|amod|END_ENTITY	Salutary effects of combining early very low-dose systemic estradiol with growth_hormone therapy in girls with Turner_syndrome .
16735135	0	estradiol	64,73	growth_hormone	33,47	estradiol	growth hormone	MESH:D004958	2688	Chemical	Gene	therapies|compound|START_ENTITY therapies|amod|END_ENTITY	Evidence for early initiation of growth_hormone and transdermal estradiol therapies in girls with Turner_syndrome .
17405836	0	estradiol	74,83	growth_hormone	22,36	estradiol	growth hormone	MESH:D004958	2688	Chemical	Gene	repletion|amod|START_ENTITY women|nmod|repletion control|nmod|women control|nmod|secretion secretion|amod|END_ENTITY	Tripartite control of growth_hormone secretion in women during controlled estradiol repletion .
1740962	0	estradiol	121,130	growth_hormone	81,95	estradiol	growth hormone	MESH:D004958	81668(Tax:10116)	Chemical	Gene	aggregates|amod|START_ENTITY release|nmod|aggregates release|nsubj|regulation regulation|nmod|dexamethasone dexamethasone|nmod|potentiation potentiation|nmod|END_ENTITY	Negative regulation by dexamethasone of the potentiation of neuromedin_C-induced growth_hormone and prolactin release by estradiol in anterior pituitary cell aggregates .
22315455	0	estradiol	71,80	growth_hormone	21,35	estradiol	growth hormone	MESH:D004958	14599(Tax:10090)	Chemical	Gene	regulation|nmod|START_ENTITY dimorphism|dep|regulation dimorphism|nmod|END_ENTITY	Sexual dimorphism of growth_hormone in the hypothalamus : regulation by estradiol .
2328688	0	estradiol	147,156	growth_hormone	15,29	estradiol	growth hormone	MESH:D004958	81668(Tax:10116)	Chemical	Gene	potentiated|advcl|START_ENTITY potentiated|nsubjpass|Stimulation Stimulation|nmod|release release|compound|END_ENTITY	Stimulation of growth_hormone and prolactin release from rat pituitary cell aggregates by bombesin - and ranatensin-like peptides is potentiated by estradiol , 5 alpha-dihydrotestosterone , and dexamethasone .
2503370	0	estradiol	149,158	growth_hormone	74,88	estradiol	growth hormone	MESH:D004958	2688	Chemical	Gene	START_ENTITY|nsubj|Changes Changes|nmod|concentrations concentrations|nmod|END_ENTITY	Changes in messenger ribonucleic acid concentrations and plasma levels of growth_hormone during the ovine estrous cycle and in response to exogenous estradiol .
25987976	0	estradiol	46,55	growth_hormone	7,21	estradiol	growth hormone	MESH:D004958	14599(Tax:10090)	Chemical	Gene	complement|amod|START_ENTITY regulation|nmod|complement END_ENTITY|dep|regulation	Neural growth_hormone : regional regulation by estradiol and/or sex chromosome complement in male and female mice .
25987976	0	estradiol	46,55	growth_hormone	7,21	estradiol	growth hormone	MESH:D004958	14599(Tax:10090)	Chemical	Gene	complement|amod|START_ENTITY regulation|nmod|complement END_ENTITY|dep|regulation	Neural growth_hormone : regional regulation by estradiol and/or sex chromosome complement in male and female mice .
3782436	0	estradiol	107,116	growth_hormone	49,63	estradiol	growth hormone	MESH:D004958	2688	Chemical	Gene	concentrations|amod|START_ENTITY importance|nmod|concentrations Effects|dep|importance Effects|nmod|profile profile|nmod|secretion secretion|amod|END_ENTITY	Effects of sex and age on the 24-hour profile of growth_hormone secretion in man : importance of endogenous estradiol concentrations .
6772428	0	estradiol	75,84	growth_hormone	3,17	estradiol	growth hormone	MESH:D004958	81668(Tax:10116)	Chemical	Gene	actions|nmod|START_ENTITY mediating|dobj|actions factor|acl|mediating factor|nsubj|END_ENTITY	Is growth_hormone the pituitary feminizing factor mediating the actions of estradiol on hepatic drug and steroid metabolism ?
8325961	0	estradiol	49,58	growth_hormone	31,45	estradiol	growth hormone	MESH:D004958	2688	Chemical	Gene	secretion|amod|START_ENTITY END_ENTITY|nmod|secretion	In vivo and in vitro effect of growth_hormone on estradiol secretion by human granulosa cells .
8552446	0	estradiol	76,85	growth_hormone	14,28	estradiol	growth hormone	MESH:D004958	2688	Chemical	Gene	production|amod|START_ENTITY regulation|nmod|production factor-I|dobj|regulation factor-I|nsubj|Comparison Comparison|nmod|growth growth|amod|END_ENTITY	Comparison of growth_hormone and insulin-like growth factor-I regulation of estradiol and progesterone production in human luteinized granulosa cells .
9086339	0	estradiol	11,20	growth_hormone	33,47	estradiol	growth hormone	MESH:D004958	2688	Chemical	Gene	Effects|nmod|START_ENTITY valerate|nsubj|Effects valerate|nmod|response response|compound|END_ENTITY	Effects of estradiol valerate on growth_hormone and prolactin response to growth_hormone-releasing_hormone stimulation in pre - and postmenopausal women .
25430541	0	estradiol	70,79	hCG	94,97	estradiol	hCG	MESH:D004958	3342	Chemical	Gene	START_ENTITY|nmod|day day|nmod|END_ENTITY	In high responding patients undergoing an initial IVF cycle , elevated estradiol on the day of hCG has no effect on live birth rate .
8505257	0	estradiol	133,142	insulin	11,18	estradiol	insulin	MESH:D004958	280829(Tax:9913)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of insulin , insulin-like_growth_factor_I , and gonadotropins on bovine granulosa cell proliferation , progesterone production , estradiol production , and -LRB- or -RRB- insulin-like_growth_factor_I production in vitro .
1311209	0	estradiol	164,173	insulin-like_growth_factor-I	14,42	estradiol	insulin-like growth factor-I	MESH:D004958	16000(Tax:10090)	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of insulin-like_growth_factor-I -LRB- IGF-I -RRB- and its receptor in the peri-implantation mouse uterus , and cell-specific regulation of IGF-I gene expression by estradiol and progesterone .
16904171	0	estradiol	102,111	insulin-like_growth_factor-I	12,40	estradiol	insulin-like growth factor-I	MESH:D004958	24482(Tax:10116)	Chemical	Gene	facilitation|amod|START_ENTITY pathways|nmod|facilitation pathways|nsubj|role role|nmod|transduction transduction|compound|END_ENTITY	The role of insulin-like_growth_factor-I and growth_factor-associated signal transduction pathways in estradiol and progesterone facilitation of female reproductive behaviors .
21735688	0	estradiol	14,23	insulin-like_growth_factor-I	54,82	estradiol	insulin-like growth factor-I	MESH:D004958	3479	Chemical	Gene	mode|amod|START_ENTITY mode|nmod|END_ENTITY	-LSB- Influence of estradiol administration mode on plasma insulin-like_growth_factor-I -LRB- IGF-I -RRB- and its binding proteins_1_and_3 concentration in postmenopausal women treated with norethisterone_acetate -RSB- .
22286784	0	estradiol	28,37	insulin-like_growth_factor-I	58,86	estradiol	insulin-like growth factor-I	MESH:D004958	3479	Chemical	Gene	START_ENTITY|nmod|relation relation|nmod|END_ENTITY	Bimodal influence of plasma estradiol on relation between insulin-like_growth_factor-I -LRB- IGF-I -RRB- and estradiol in women .
18446778	0	estradiol	98,107	insulin-like_growth_factor-I_receptor	47,84	estradiol	insulin-like growth factor-I receptor	MESH:D004958	25718(Tax:10116)	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Pubertal maturation modifies the regulation of insulin-like_growth_factor-I_receptor signaling by estradiol in the rat prefrontal cortex .
10774110	0	estradiol	68,77	interleukin-6	27,40	estradiol	interleukin-6	MESH:D004958	3569	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|amod|END_ENTITY	-LSB- Effect of intrafollicular interleukin-6 levels on the secretion of estradiol and progesterone in patients treated with in vitro fertilization and embryo transfer -RSB- .
11415991	0	estradiol	24,33	interleukin-6	74,87	estradiol	interleukin-6	MESH:D004958	3569	Chemical	Gene	responses|amod|START_ENTITY effects|nmod|responses effects|nmod|END_ENTITY	Differential effects of estradiol on the adrenocorticotropin responses to interleukin-6 and interleukin-1 in the monkey .
8312448	0	estradiol	83,92	interleukin-6	11,24	estradiol	interleukin-6	MESH:D004958	280826(Tax:9913)	Chemical	Gene	production|amod|START_ENTITY production|amod|END_ENTITY	Effects of interleukin-6 on proliferation and follicle-stimulating hormone-induced estradiol production by bovine granulosa cells in vitro : dependence on size of follicle .
22129622	0	estradiol	28,37	interleukin-8	11,24	estradiol	interleukin-8	MESH:D004958	280828(Tax:9913)	Chemical	Gene	production|amod|START_ENTITY Effects|nmod|production Effects|nmod|END_ENTITY	Effects of interleukin-8 on estradiol and progesterone production by bovine granulosa cells from large follicles and progesterone production by luteinizing granulosa cells in culture .
10329991	0	estradiol	5,14	leptin	23,29	estradiol	leptin	MESH:D004958	16846(Tax:10090)	Chemical	Gene	mediate|nsubj|START_ENTITY mediate|dobj|effects effects|nmod:poss|END_ENTITY	Does estradiol mediate leptin 's effects on adiposity and body weight ?
11791088	0	estradiol	25,34	leptin	56,62	estradiol	leptin	MESH:D004958	3952	Chemical	Gene	START_ENTITY|nmod|regulation regulation|nmod|levels levels|compound|END_ENTITY	Influence of transdermal estradiol in the regulation of leptin levels of postmenopausal women : a double-blind , placebo-controlled study .
17043388	0	estradiol	21,30	leptin	76,82	estradiol	leptin	MESH:D004958	280836(Tax:9913)	Chemical	Gene	START_ENTITY|nmod|concentrations concentrations|nmod|END_ENTITY	Effects of exogenous estradiol and progesterone on plasma concentrations of leptin in ewes in non-breeding season .
18084865	0	estradiol	137,146	leptin	16,22	estradiol	leptin	MESH:D004958	3952	Chemical	Gene	levels|amod|START_ENTITY associated|dobj|levels associated|nsubj|levels levels|compound|END_ENTITY	Elevated plasma leptin levels associated with high_blood_pressure and TG rich lipoproteins but not associated with plasma gonadotropins , estradiol and cortisol levels in peri - and postmenopausal lean women with undefined symptoms .
22703959	0	estradiol	11,20	leptin	32,38	estradiol	leptin	MESH:D004958	3952	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|compound|END_ENTITY	Effects of estradiol and FSH on leptin levels in women with suppressed pituitary .
7961235	0	estradiol	11,20	lipoprotein_lipase	24,42	estradiol	lipoprotein lipase	MESH:D004958	24539(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|amod|END_ENTITY	Effects of estradiol on lipoprotein_lipase activity and lipid availability in exercised male rats .
3520372	0	estradiol	11,20	luteinizing_hormone-releasing_hormone	78,115	estradiol	luteinizing hormone-releasing hormone	MESH:D004958	25194(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of estradiol and progesterone on immunoreactive forms of hypothalamic luteinizing_hormone-releasing_hormone .
3543719	0	estradiol	108,117	luteinizing_hormone-releasing_hormone	28,65	estradiol	luteinizing hormone-releasing hormone	MESH:D004958	25194(Tax:10116)	Chemical	Gene	participate|nmod|START_ENTITY participate|nsubj|neurons neurons|amod|END_ENTITY	Morphological evidence that luteinizing_hormone-releasing_hormone neurons participate in the suppression by estradiol of pituitary luteinizing hormone secretion in ovariectomized rats .
7506207	0	estradiol	112,121	luteinizing_hormone-releasing_hormone	36,73	estradiol	luteinizing hormone-releasing hormone	MESH:D004958	25194(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY effect|nmod|treatment effect|dep|Aging Aging|nmod|neurons neurons|amod|END_ENTITY	Aging impairs galanin expression in luteinizing_hormone-releasing_hormone neurons : effect of ovariectomy and/or estradiol treatment .
9861542	0	estradiol	20,29	luteinizing_hormone-releasing_hormone	37,74	estradiol	luteinizing hormone-releasing hormone	MESH:D004958	443529(Tax:9940)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Temporal effects of estradiol -LRB- E -RRB- on luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- and LH release in castrated male sheep .
12126567	0	estradiol	66,75	macrophage_colony-stimulating_factor	12,48	estradiol	macrophage colony-stimulating factor	MESH:D004958	1435	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of macrophage_colony-stimulating_factor on production of estradiol and progesterone by human luteinized granulosa cells in vitro and detection of macrophage_colony-stimulating_factor receptor on human luteinized granulosa cells -RSB- .
12126567	0	estradiol	66,75	macrophage_colony-stimulating_factor	155,191	estradiol	macrophage colony-stimulating factor	MESH:D004958	1435	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|receptor receptor|amod|END_ENTITY	-LSB- Effects of macrophage_colony-stimulating_factor on production of estradiol and progesterone by human luteinized granulosa cells in vitro and detection of macrophage_colony-stimulating_factor receptor on human luteinized granulosa cells -RSB- .
14680610	0	estradiol	11,20	macrophage_colony-stimulating_factor	55,91	estradiol	macrophage colony-stimulating factor	MESH:D004958	1435	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of estradiol and progesterone on production of macrophage_colony-stimulating_factor by human granulosa cells in vitro -RSB- .
25063027	0	estradiol	14,23	miR-148a	32,40	estradiol	miR-148a	MESH:D004958	406940	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|xcomp|END_ENTITY	GPER mediated estradiol reduces miR-148a to promote HLA-G expression in breast_cancer .
11875328	0	estradiol	12,21	myeloperoxidase	37,52	estradiol	myeloperoxidase	MESH:D004958	4353	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|levels levels|compound|END_ENTITY	Transdermal estradiol reduces plasma myeloperoxidase levels without affecting the LDL resistance to oxidation or the LDL particle size .
16207548	0	estradiol	23,32	nitric_oxide_synthase	42,63	estradiol	nitric oxide synthase	MESH:D004958	4846	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|xcomp|END_ENTITY	Short-term transdermal estradiol enhances nitric_oxide_synthase III and estrogen receptor mRNA expression in arteries of women with coronary_artery_disease .
8302868	0	estradiol	94,103	oxidoreductase	58,72	estradiol	oxidoreductase	MESH:D004958	855266(Tax:4932)	Chemical	Gene	inhibited|nmod|START_ENTITY END_ENTITY|acl:relcl|inhibited	Candida_albicans estrogen-binding protein gene encodes an oxidoreductase that is inhibited by estradiol .
2328691	0	estradiol	35,44	oxytocin	23,31	estradiol	oxytocin	MESH:D004958	100152272(Tax:9823)	Chemical	Gene	secretion|amod|START_ENTITY END_ENTITY|nmod|secretion	Release and effects of oxytocin on estradiol and progesterone secretion in porcine corpora lutea as measured by an in vivo microdialysis system .
2909373	0	estradiol	21,30	parathyroid_hormone	85,104	estradiol	parathyroid hormone	MESH:D004958	5741	Chemical	Gene	START_ENTITY|nmod|response response|nmod|cells cells|dep|END_ENTITY	Direct modulation by estradiol of the response of human bone cells -LRB- SaOS-2 -RRB- to human parathyroid_hormone -LRB- PTH -RRB- and PTH-related protein .
3350908	0	estradiol	11,20	parathyroid_hormone	41,60	estradiol	parathyroid hormone	MESH:D004958	5741	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|amod|END_ENTITY	Effects of estradiol and progesterone on parathyroid_hormone secretion from human parathyroid tissue .
7758828	0	estradiol	68,77	peptide_23	24,34	estradiol	peptide 23	MESH:D004958	24618(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY Expression|dep|regulation Expression|nmod|END_ENTITY	Expression of pituitary peptide_23 in the rat uterus : regulation by estradiol .
19494505	0	estradiol	98,107	peroxisome_proliferator-activated_receptor-gamma	14,62	estradiol	peroxisome proliferator-activated receptor-gamma	MESH:D004958	5468	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of peroxisome_proliferator-activated_receptor-gamma expression in human eosinophils by estradiol .
10589507	0	estradiol	117,126	progesterone_receptor	14,35	estradiol	progesterone receptor	MESH:D004958	396198(Tax:9031)	Chemical	Gene	Evidence|amod|START_ENTITY Evidence|nmod|END_ENTITY	Evidence of a progesterone_receptor in the liver of the green frog Rana esculenta and its down-regulation by 17 beta estradiol and progesterone .
10727249	0	estradiol	60,69	progesterone_receptor	35,56	estradiol	progesterone receptor	MESH:D004958	18667(Tax:10090)	Chemical	Gene	tract|amod|START_ENTITY END_ENTITY|nmod|tract	Paracrine regulation of epithelial progesterone_receptor by estradiol in the mouse female reproductive tract .
11165037	0	estradiol	89,98	progesterone_receptor	15,36	estradiol	progesterone receptor	MESH:D004958	5241	Chemical	Gene	effects|nmod|START_ENTITY control|dep|effects control|nmod|expression expression|compound|END_ENTITY	The control of progesterone_receptor expression in MCF-7 breast_cancer cells : effects of estradiol and sex_hormone-binding_globulin -LRB- SHBG -RRB- .
1546047	0	estradiol	49,58	progesterone_receptor	15,36	estradiol	progesterone receptor	MESH:D004958	5241	Chemical	Gene	bindings|nmod|START_ENTITY bindings|nsubj|Enhancement Enhancement|nmod|END_ENTITY	Enhancement of progesterone_receptor bindings by estradiol in pituitary cells of the hen .
18308846	0	estradiol	50,59	progesterone_receptor	14,35	estradiol	progesterone receptor	MESH:D004958	25154(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Regulation of progesterone_receptor expression by estradiol is dependent on age , sex and region in the rat brain .
3112670	0	estradiol	53,62	progesterone_receptor	18,39	estradiol	progesterone receptor	MESH:D004958	25154(Tax:10116)	Chemical	Gene	synthesis|nmod|START_ENTITY synthesis|compound|END_ENTITY	Priming action on progesterone_receptor synthesis by estradiol and tamoxifen in the 7,12-dimethylbenz -LRB- a -RRB- anthracene-induced rat mammary carcinoma .
3342760	0	estradiol	100,109	progesterone_receptor	14,35	estradiol	progesterone receptor	MESH:D004958	5241	Chemical	Gene	cells|nmod|START_ENTITY ribonucleic_acid|nmod|cells ribonucleic_acid|amod|END_ENTITY	Regulation of progesterone_receptor messenger ribonucleic_acid and protein levels in MCF-7 cells by estradiol : analysis of estrogen 's effect on progesterone_receptor synthesis and degradation .
3342760	0	estradiol	100,109	progesterone_receptor	144,165	estradiol	progesterone receptor	MESH:D004958	5241	Chemical	Gene	cells|nmod|START_ENTITY ribonucleic_acid|nmod|cells Regulation|nmod|ribonucleic_acid Regulation|dep|analysis analysis|nmod|effect effect|nmod|synthesis synthesis|compound|END_ENTITY	Regulation of progesterone_receptor messenger ribonucleic_acid and protein levels in MCF-7 cells by estradiol : analysis of estrogen 's effect on progesterone_receptor synthesis and degradation .
3381634	0	estradiol	10,19	progesterone_receptor	27,48	estradiol	progesterone receptor	MESH:D004958	25154(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of estradiol on the progesterone_receptor and on morphological ultrastructures in the fetal and newborn uterus and ovary of the rat .
3448706	0	estradiol	129,138	progesterone_receptor	78,99	estradiol	progesterone receptor	MESH:D004958	25154(Tax:10116)	Chemical	Gene	uteri|nmod|START_ENTITY END_ENTITY|nmod|uteri	Relationship between occupied form of nuclear estrogen receptor and cytosolic progesterone_receptor or DNA synthesis in uteri of estradiol implanted rats .
6270327	0	estradiol	51,60	progesterone_receptor	18,39	estradiol	progesterone receptor	MESH:D004958	5241	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|END_ENTITY	The regulation of progesterone_receptor by 17 beta estradiol and tamoxifen in the Zr-75-1 human breast_cancer cell line in defined medium .
6696963	0	estradiol	20,29	progesterone_receptor	33,54	estradiol	progesterone receptor	MESH:D004958	100009094(Tax:9986)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|synthesis synthesis|compound|END_ENTITY	Temporal effects of estradiol on progesterone_receptor and glycoprotein synthesis in the epithelial-stromal complex of the rabbit endocervix .
748014	0	estradiol	74,83	progesterone_receptor	20,41	estradiol	progesterone receptor	MESH:D004958	5241	Chemical	Gene	role|nmod|START_ENTITY control|dep|role control|nmod|END_ENTITY	Estrogen control of progesterone_receptor in human breast_cancer : role of estradiol and antiestrogen .
10397281	0	estradiol	27,36	prolactin	61,70	estradiol	prolactin	MESH:D004958	5617	Chemical	Gene	cortisol|compound|START_ENTITY cortisol|dep|END_ENTITY	Acute effect of alcohol on estradiol , estrone , progesterone , prolactin , cortisol , and luteinizing hormone in premenopausal women .
11887934	0	estradiol	82,91	prolactin	24,33	estradiol	prolactin	MESH:D004958	24683(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY regulation|dep|role regulation|nmod|secretion secretion|compound|END_ENTITY	Autocrine regulation of prolactin secretion by endothelins : a permissive role for estradiol .
121822	0	estradiol	84,93	prolactin	52,61	estradiol	prolactin	MESH:D004958	5617	Chemical	Gene	steroids|dep|START_ENTITY steroids|compound|END_ENTITY	Patterns of circulating gonadotropins -LRB- LH and FSH -RRB- , prolactin and ovarian steroids -LRB- estradiol and progesterone -RRB- during the menstrual cycle in Korean women .
1508941	0	estradiol	20,29	prolactin	77,86	estradiol	prolactin	MESH:D004958	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Temporal effects of estradiol and diethylstilbestrol on pituitary and plasma prolactin levels in ovariectomized Fischer 344 and Holtzman rats : a comparison of radioimmunoassay and Nb2 lymphoma cell bioassay .
1710752	0	estradiol	26,35	prolactin	47,56	estradiol	prolactin	MESH:D004958	24683(Tax:10116)	Chemical	Gene	17-beta|amod|START_ENTITY 17-beta|nmod|mRNA mRNA|compound|END_ENTITY	The stimulatory effect of estradiol 17-beta on prolactin mRNA is inhibited by anti-calmodulin drugs .
18064358	0	estradiol	35,44	prolactin	126,135	estradiol	prolactin	MESH:D004958	24683(Tax:10116)	Chemical	Gene	intraoviductal|amod|START_ENTITY shifts|amod|intraoviductal shifts|acl|signaling signaling|nmod|END_ENTITY	Genital sensory stimulation shifts estradiol intraoviductal signaling from nongenomic to genomic pathways , independently from prolactin surges .
19326843	0	estradiol	11,20	prolactin	96,105	estradiol	prolactin	MESH:D004958	5617	Chemical	Gene	Effect|nmod|START_ENTITY Effect|acl|stimulated stimulated|nmod|theophylline theophylline|compound|END_ENTITY	-LSB- Effect of estradiol on Ca2 + release from intracellular stores in porcine oocytes stimulated by prolactin , theophylline , or guanosine_triphosphate -RSB- .
223691	0	estradiol	34,43	prolactin	47,56	estradiol	prolactin	MESH:D004958	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	-LSB- Characteristics of the effect of estradiol on prolactin secretion by adenohyophyseal cells from intact and ovariectomized rats in primary monolayer cultures -RSB- .
2536446	0	estradiol	51,60	prolactin	116,125	estradiol	prolactin	MESH:D004958	24683(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY mediating|dobj|effects mediating|advcl|controlling controlling|dobj|secretion secretion|compound|END_ENTITY	2-Hydroxyestradiol is not mediating the effects of estradiol on tuberoinfundibular dopaminergic neurons controlling prolactin secretion in female rats .
2589434	0	estradiol	25,34	prolactin	134,143	estradiol	prolactin	MESH:D004958	5617	Chemical	Gene	induction|nmod:poss|START_ENTITY subserve|dobj|induction Mechanisms|acl:relcl|subserve Mechanisms|dep|evidence evidence|nmod|modulation modulation|nmod|bursts bursts|compound|END_ENTITY	Mechanisms that subserve estradiol 's induction of increased prolactin concentrations : evidence of amplitude modulation of spontaneous prolactin secretory bursts .
2589434	0	estradiol	25,34	prolactin	60,69	estradiol	prolactin	MESH:D004958	5617	Chemical	Gene	induction|nmod:poss|START_ENTITY induction|nmod|concentrations concentrations|compound|END_ENTITY	Mechanisms that subserve estradiol 's induction of increased prolactin concentrations : evidence of amplitude modulation of spontaneous prolactin secretory bursts .
2744414	0	estradiol	24,33	prolactin	132,141	estradiol	prolactin	MESH:D004958	5617	Chemical	Gene	production|amod|START_ENTITY suppressed|nsubjpass|production suppressed|nmod|concentrations concentrations|nmod|END_ENTITY	Gonadotropin-stimulated estradiol production in small ovarian follicles of the hen is suppressed by physiological concentrations of prolactin in vitro .
284404	0	estradiol	64,73	prolactin	86,95	estradiol	prolactin	MESH:D004958	24683(Tax:10116)	Chemical	Gene	rats|nmod|START_ENTITY Comparison|nmod|rats Comparison|nmod|terms terms|nmod|synthesis synthesis|compound|END_ENTITY	Comparison of primary and secondary stimulation of male rats by estradiol in terms of prolactin synthesis and mRNA accumulation in the pituitary .
3113249	0	estradiol	22,31	prolactin	77,86	estradiol	prolactin	MESH:D004958	5617	Chemical	Gene	actions|nmod|START_ENTITY actions|nmod|END_ENTITY	Modulating actions of estradiol on gonadotropin-releasing_hormone-stimulated prolactin secretion in postmenopausal individuals .
3194578	0	estradiol	11,20	prolactin	46,55	estradiol	prolactin	MESH:D004958	24683(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of estradiol on circulating levels of prolactin in female rats bearing ectopic pituitaries .
3207131	0	estradiol	26,35	prolactin	75,84	estradiol	prolactin	MESH:D004958	5617	Chemical	Gene	concentration|amod|START_ENTITY Influence|nmod|concentration Influence|nmod|patterns patterns|amod|END_ENTITY	Influence of preovulatory estradiol concentration on diurnal and pulsatile prolactin secretion patterns .
485635	0	estradiol	37,46	prolactin	50,59	estradiol	prolactin	MESH:D004958	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Effect of aromatizable androgens and estradiol on prolactin secretion in prepuberal male rats .
572974	0	estradiol	11,20	prolactin	28,37	estradiol	prolactin	MESH:D004958	24683(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|content content|compound|END_ENTITY	-LSB- Effect of estradiol on the prolactin content in the adenohypophysis of sexually mature and immature rats -RSB- .
606670	0	estradiol	10,19	prolactin	52,61	estradiol	prolactin	MESH:D004958	24683(Tax:10116)	Chemical	Gene	_|amod|START_ENTITY Effect|nmod|_ testosterone|nsubj|Effect testosterone|nmod|levels levels|compound|END_ENTITY	Effect of estradiol _ testosterone on the pituitary prolactin levels in developing male _ female rats .
6119146	0	estradiol	49,58	prolactin	22,31	estradiol	prolactin	MESH:D004958	24683(Tax:10116)	Chemical	Gene	primed|dep|START_ENTITY rat|amod|primed secretion|nmod|rat secretion|compound|END_ENTITY	Somatostatin inhibits prolactin secretion in the estradiol primed male rat .
6448002	0	estradiol	38,47	prolactin	7,16	estradiol	prolactin	MESH:D004958	5617	Chemical	Gene	dehydroepiandrosterone_sulfate|compound|START_ENTITY Stable|nmod|dehydroepiandrosterone_sulfate Stable|dobj|level level|compound|END_ENTITY	Stable prolactin level after enhanced estradiol production following dehydroepiandrosterone_sulfate .
6504266	0	estradiol	25,34	prolactin	140,149	estradiol	prolactin	MESH:D004958	24683(Tax:10116)	Chemical	Gene	treatment|nmod|START_ENTITY induces|nsubj|treatment induces|dobj|alterations alterations|dep|responsiveness responsiveness|nmod|END_ENTITY	Long-term treatment with estradiol induces reversible alterations in tuberoinfundibular dopaminergic neurons : a decreased responsiveness to prolactin .
6575400	0	estradiol	14,23	prolactin	52,61	estradiol	prolactin	MESH:D004958	5617	Chemical	Gene	START_ENTITY|nmod|effect effect|nmod|END_ENTITY	Inhibition by estradiol of the lactogenic effect of prolactin in primate mammary tissue : reversal by antiestrogens LY_156758 and tamoxifen .
7007025	0	estradiol	55,64	prolactin	17,26	estradiol	prolactin	MESH:D004958	24683(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nmod|effect	Possible role of prolactin in the inhibitory effect of estradiol on the hypothalamic-pituitary-testicular axis in the rat .
7192623	0	estradiol	19,28	prolactin	62,71	estradiol	prolactin	MESH:D004958	5617	Chemical	Gene	START_ENTITY|acl|modifying modifying|dobj|secretion secretion|compound|END_ENTITY	The interaction of estradiol and daylength in modifying serum prolactin secretion in female hamsters .
7410533	0	estradiol	96,105	prolactin	23,32	estradiol	prolactin	MESH:D004958	5617	Chemical	Gene	secretion|nmod|START_ENTITY effect|nmod|secretion have|dobj|effect have|nsubj|changes changes|nmod|concentration concentration|compound|END_ENTITY	Acute changes in serum prolactin concentration have no effect on the secretion of progesterone , estradiol , or chorionic gonadotropin during early pregnancy .
7890253	0	estradiol	73,82	prolactin	37,46	estradiol	prolactin	MESH:D004958	5617	Chemical	Gene	replacement|amod|START_ENTITY using|dobj|replacement Effect|acl|using Effect|nmod|ingestion ingestion|nmod|END_ENTITY	Effect of acute ethanol ingestion on prolactin in menopausal women using estradiol replacement .
8142551	0	estradiol	59,68	prolactin	27,36	estradiol	prolactin	MESH:D004958	24683(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY secretion|dep|effects secretion|compound|END_ENTITY	Constitutive and regulated prolactin secretion : effects of estradiol .
8502593	0	estradiol	99,108	prolactin	88,97	estradiol	prolactin	MESH:D004958	5617	Chemical	Gene	START_ENTITY|nsubj|lutropin lutropin|appos|END_ENTITY	-LSB- The effect of long-term prazosin treatment on plasma follitropin -LRB- FSH -RRB- , lutropin -LRB- LH -RRB- , prolactin , estradiol and testosterone concentration in male patients with essential hypertension -RSB- .
8801137	0	estradiol	40,49	prolactin	12,21	estradiol	prolactin	MESH:D004958	24683(Tax:10116)	Chemical	Gene	action|amod|START_ENTITY role|nmod|action role|nmod|END_ENTITY	The role of prolactin in realization of estradiol action in the uterus of ovariectomized rats .
8857606	0	estradiol	108,117	prolactin	54,63	estradiol	prolactin	MESH:D004958	24683(Tax:10116)	Chemical	Gene	action|nmod|START_ENTITY induced|nmod|action induced|nsubj|Participation Participation|nmod|opioid_and_serotoninergic_systems opioid_and_serotoninergic_systems|nmod|secretion secretion|compound|END_ENTITY	Participation of opioid_and_serotoninergic_systems in prolactin secretion induced by hypothalamic action of estradiol .
8957741	0	estradiol	35,44	prolactin	59,68	estradiol	prolactin	MESH:D004958	24683(Tax:10116)	Chemical	Gene	modulates|amod|START_ENTITY administration|nmod|modulates rat|nsubj|administration rat|dobj|secretion secretion|amod|END_ENTITY	Intraventricular administration of estradiol modulates rat prolactin secretion and synthesis .
963145	0	estradiol	87,96	prolactin	19,28	estradiol	prolactin	MESH:D004958	19109(Tax:10090)	Chemical	Gene	implants|nmod|START_ENTITY bearing|dobj|implants mice|acl|bearing END_ENTITY|nmod|mice	Serum FSH , LH , and prolactin in adult ovariectomized mice bearing silastic implants of estradiol : responses to social cues .
8741757	0	estradiol	47,56	prolactin_receptor	14,32	estradiol	prolactin receptor	MESH:D004958	24684(Tax:10116)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of prolactin_receptor expression by estradiol in the female rat brain .
10759011	0	estradiol	82,91	protein_C	120,129	estradiol	protein C	MESH:D004958	5624	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Beneficial effects of postmenopausal hormone replacement therapy with transdermal estradiol on sensitivity to activated protein_C .
21605449	0	estradiol	87,96	s100_calcium_binding_protein_G	31,61	estradiol	s100 calcium binding protein G	MESH:D004958	24249(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nmod|effect	Participation of the oviductal s100_calcium_binding_protein_G in the genomic effect of estradiol that accelerates oviductal embryo transport in mated rats .
1281127	0	estradiol	7,16	secretogranin_II	36,52	estradiol	secretogranin II	MESH:D004958	24765(Tax:10116)	Chemical	Gene	down-regulation|amod|START_ENTITY down-regulation|nmod|levels levels|compound|END_ENTITY	Direct estradiol down-regulation of secretogranin_II and chromogranin_A mRNA levels in rat pituitary cells .
10914617	0	estradiol	161,170	sex_hormone-binding_globulin	131,159	estradiol	sex hormone-binding globulin	MESH:D004958	6462	Chemical	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Serum estradiol-binding profiles in postmenopausal women undergoing three common estrogen replacement therapies : associations with sex_hormone-binding_globulin , estradiol , and estrone levels .
12228253	0	estradiol	174,183	sex_hormone-binding_globulin	27,55	estradiol	sex hormone-binding globulin	MESH:D004958	6462	Chemical	Gene	derivatives|nmod|START_ENTITY reveals|nmod|derivatives reveals|nsubj|structure structure|nmod|END_ENTITY	Crystal structure of human sex_hormone-binding_globulin in complex with 2-methoxyestradiol reveals the molecular basis for high affinity interactions with C-2 derivatives of estradiol .
12521235	0	estradiol	79,88	sex_hormone-binding_globulin	120,148	estradiol	sex hormone-binding globulin	MESH:D004958	6462	Chemical	Gene	lutropin|appos|START_ENTITY lutropin|amod|END_ENTITY	Reference ranges for serum concentrations of lutropin -LRB- LH -RRB- , follitropin -LRB- FSH -RRB- , estradiol -LRB- E2 -RRB- , prolactin , progesterone , sex_hormone-binding_globulin -LRB- SHBG -RRB- , dehydroepiandrosterone_sulfate -LRB- DHEAS -RRB- , cortisol and ferritin in neonates , children and young adults .
19679209	0	estradiol	81,90	sex_hormone-binding_globulin	32,60	estradiol	sex hormone-binding globulin	MESH:D004958	6462	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|polymorphisms polymorphisms|nmod|gene gene|amod|END_ENTITY	Effects of polymorphisms of the sex_hormone-binding_globulin -LRB- SHBG -RRB- gene on free estradiol and bone_mineral_density .
3093520	0	estradiol	6,15	sex_hormone-binding_globulin	102,130	estradiol	sex hormone-binding globulin	MESH:D004958	6462	Chemical	Gene	bound|nsubj|START_ENTITY bound|nmod|END_ENTITY	Total estradiol , free estradiol , sex_hormone-binding_globulin , and the fraction of estradiol bound to sex_hormone-binding_globulin in human follicular fluid .
3417844	0	estradiol	120,129	sex_hormone-binding_globulin	66,94	estradiol	sex hormone-binding globulin	MESH:D004958	6462	Chemical	Gene	binding|amod|START_ENTITY alteration|nmod|binding Differential|dep|alteration Differential|nmod|END_ENTITY	Differential binding of testosterone and estradiol to isoforms of sex_hormone-binding_globulin : selective alteration of estradiol binding in cirrhosis .
6538387	0	estradiol	66,75	sex_hormone-binding_globulin	5,33	estradiol	sex hormone-binding globulin	MESH:D004958	6462	Chemical	Gene	transport|nmod|START_ENTITY role|nmod|transport play|dobj|role play|nsubj|END_ENTITY	Does sex_hormone-binding_globulin play a role in the transport of estradiol in vivo ?
9228496	0	estradiol	32,41	sex_hormone-binding_globulin	52,80	estradiol	sex hormone-binding globulin	MESH:D004958	6462	Chemical	Gene	weeks|nmod|START_ENTITY increases|nsubj|weeks increases|dobj|END_ENTITY	Twenty two weeks of transdermal estradiol increases sex_hormone-binding_globulin in surgical menopausal women .
15474089	0	estradiol	48,57	soluble_guanylyl_cyclase	14,38	estradiol	soluble guanylyl cyclase	MESH:D004958	497757(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY inhibits|dobj|production inhibits|nsubj|Activation Activation|nmod|END_ENTITY	Activation of soluble_guanylyl_cyclase inhibits estradiol production and cyclic_AMP accumulation from cultured rat granulosa cells .
17408863	0	estradiol	54,63	spinophilin	98,109	estradiol	spinophilin	MESH:D004958	84686(Tax:10116)	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Exploration of prostanoid receptor subtype regulating estradiol and prostaglandin_E2 induction of spinophilin in developing preoptic area neurons .
1908714	0	estradiol	102,111	thymosin_alpha_1_and_beta_4	20,47	estradiol	thymosin alpha 1 and beta 4	MESH:D004958	100137883(Tax:9913)	Chemical	Gene	effects|nmod|START_ENTITY Characterization|dep|effects Characterization|nmod|END_ENTITY	Characterization of thymosin_alpha_1_and_beta_4 during the bovine estrual period : effects of elevated estradiol and progestin .
10438721	0	estradiol	89,98	tissue-type_plasminogen_activator	52,85	estradiol	tissue-type plasminogen activator	MESH:D004958	18791(Tax:10090)	Chemical	Gene	explains|nmod|START_ENTITY explains|dobj|levels levels|nmod|END_ENTITY	Increased clearance explains lower plasma levels of tissue-type_plasminogen_activator by estradiol : evidence for potently enhanced mannose receptor expression in mice .
1478614	0	estradiol	24,33	tissue-type_plasminogen_activator	37,70	estradiol	tissue-type plasminogen activator	MESH:D004958	25692(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Specific stimulation by estradiol of tissue-type_plasminogen_activator production in 7,12-dimethylbenz -LSB- a -RSB- anthracene-induced rat mammary tumor cells .
16891052	0	estradiol	44,53	tumor_necrosis_factor-alpha	13,40	estradiol	tumor necrosis factor-alpha	MESH:D004958	7124	Chemical	Gene	growth|amod|START_ENTITY END_ENTITY|nmod|growth	Influence of tumor_necrosis_factor-alpha on estradiol , progesterone , insulin-like growth factor-II , and insulin-like_growth_factor_binding_protein-1 , _ 2 , _ and_3 in cultured human luteinized granulosa cells .
3127403	0	estradiol	55,64	tyrosinase	32,42	estradiol	tyrosinase	MESH:D004958	7299	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Inhibition of imidazole-induced tyrosinase activity by estradiol and estriol in cultured B16/C3 melanoma cells .
19215508	0	estradiol	28,37	tyrosine_hydroxylase	80,100	estradiol	tyrosine hydroxylase	MESH:D004958	25085(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY actions|nmod|treatment actions|nmod|activity activity|nmod|END_ENTITY	Inhibitory actions of acute estradiol treatment on the activity and quantity of tyrosine_hydroxylase in the median eminence of ovariectomized rats .
8097235	0	estradiol	32,41	tyrosine_hydroxylase	45,65	estradiol	tyrosine hydroxylase	MESH:D004958	25085(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Short-term inhibitory effect of estradiol on tyrosine_hydroxylase activity in tuberoinfundibular dopaminergic neurons in vitro .
9042376	0	estradiol	14,23	tyrosine_hydroxylase	43,63	estradiol	tyrosine hydroxylase	MESH:D004958	25085(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|aminotransferase aminotransferase|amod|END_ENTITY	The effect of estradiol and ovariectomy on tyrosine_hydroxylase , tyrosine aminotransferase and phenylalanine_hydroxylase .
16021854	0	estradiol	24,33	vascular_endothelial_growth_factor	70,104	estradiol	vascular endothelial growth factor	MESH:D004958	7422	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	The effect of exogenous estradiol treatment on the mRNA expression of vascular_endothelial_growth_factor and its receptors in cultured human oviduct mucosal cells .
16394178	0	estradiol	82,91	vascular_endothelial_growth_factor	18,52	estradiol	vascular endothelial growth factor	MESH:D004958	7422	Chemical	Gene	Flk-1|nmod|START_ENTITY Flk-1|nsubj|Regulation Regulation|nmod|receptor receptor|compound|END_ENTITY	Regulation of the vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor Flk-1 / KDR by estradiol through VEGF in uterus .
17334879	0	estradiol	13,22	vascular_endothelial_growth_factor	26,60	estradiol	vascular endothelial growth factor	MESH:D004958	397157(Tax:9823)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Influence of estradiol on vascular_endothelial_growth_factor expression in bone : a study in G ttingen miniature pigs and human osteoblasts .
19819950	0	estradiol	81,90	vascular_endothelial_growth_factor	104,138	estradiol	vascular endothelial growth factor	MESH:D004958	7422	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|expression expression|compound|END_ENTITY	Inhibition of oxygen-induced hypoxia-inducible_factor-1alpha degradation unmasks estradiol induction of vascular_endothelial_growth_factor expression in ECC-1 cancer cells in vitro .
20093283	0	estradiol	86,95	vascular_endothelial_growth_factor	14,48	estradiol	vascular endothelial growth factor	MESH:D004958	83785(Tax:10116)	Chemical	Gene	stimulated|nmod|START_ENTITY stimulated|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of vascular_endothelial_growth_factor in the growth plate is stimulated by estradiol and increases during pubertal development .
8752163	0	estradiol	73,82	vascular_endothelial_growth_factor	22,56	estradiol	vascular endothelial growth factor	MESH:D004958	83785(Tax:10116)	Chemical	Gene	increased|nmod|START_ENTITY increased|nsubjpass|expression expression|nmod|END_ENTITY	Uterine expression of vascular_endothelial_growth_factor is increased by estradiol and tamoxifen .
8034005	0	estradiol	11,20	very_low_density_lipoprotein_receptor	24,61	estradiol	very low density lipoprotein receptor	MESH:D004958	100008976(Tax:9986)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|compound|END_ENTITY	Effects of estradiol on very_low_density_lipoprotein_receptor mRNA levels in rabbit heart .
2054151	0	estradiol-17	31,43	LHRH	11,15	estradiol-17	LHRH	null	25194(Tax:10116)	Chemical	Gene	beta|amod|START_ENTITY beta|amod|END_ENTITY	Effects of LHRH , progesterone , estradiol-17 beta and dexamethasone in vitro on pineal synaptic ribbons and serotonin_N-acetyltransferase activity in diestrous rats .
3432558	0	estradiol-17_beta_and_actinomycin_D	14,49	PGF	68,71	estradiol-17 beta and actinomycin D	PGF	null	5228	Chemical	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	The effect of estradiol-17_beta_and_actinomycin_D on the release of PGF and PGE from separated cells of human endometrium .
8389226	0	estradiol_17_beta-hydroxysteroid	34,66	EDH17B2	96,103	estradiol 17 beta-hydroxysteroid	EDH17B2	null	3292	Chemical	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Detection of polymorphisms in the estradiol_17_beta-hydroxysteroid dehydrogenase II gene at the EDH17B2 locus on 17q11-q21 .
10564741	0	estradiol_benzoate	15,33	choline_acetyltransferase	65,90	estradiol benzoate	choline acetyltransferase	MESH:C074283	290567(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|activity activity|compound|END_ENTITY	Raloxifene and estradiol_benzoate both fully restore hippocampal choline_acetyltransferase activity in ovariectomized rats .
3453420	0	estradiol_benzoate	88,106	estradiol_receptor	8,26	estradiol benzoate	estradiol receptor	MESH:C074283	24890(Tax:10116)	Chemical	Gene	treatment|nmod|START_ENTITY END_ENTITY|nmod|treatment	Cytosol estradiol_receptor content in the adult rat brain after neonatal treatment with estradiol_benzoate or testosterone_propionate .
18795083	0	estradiole	17,27	leptin	59,65	estradiole	leptin	null	3952	Chemical	Gene	administration|amod|START_ENTITY influence|nmod|administration influence|nmod|levels levels|compound|END_ENTITY	The influence of estradiole and tibolone administration on leptin levels in women with surgically induced menopause .
15881884	0	estragole	11,20	tyrosine_aminotransferase	52,77	estragole	tyrosine aminotransferase	MESH:C007633	24813(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|induction induction|nmod|END_ENTITY	-LSB- Effect of estragole on glucocorticoid induction of tyrosine_aminotransferase and tryprophan oxygenase in the rat and mouse liver -RSB- .
1145919	1	estramustine_phosphate	59,81	Transcortin	18,29	estramustine phosphate	Transcortin	CHEBI:68643	866	Chemical	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	Transcortin levels during treatment with estramustine_phosphate .
10076535	0	estramustine_phosphate	32,54	androgen_receptor	98,115	estramustine phosphate	androgen receptor	CHEBI:68643	367	Chemical	Gene	effect|nmod|START_ENTITY metabolites|nsubj|effect metabolites|nmod|END_ENTITY	Androgen antagonistic effect of estramustine_phosphate -LRB- EMP -RRB- metabolites on wild-type and mutated androgen_receptor .
510999	0	estramustine_phosphate	35,57	estrogen_receptor	78,95	estramustine phosphate	estrogen receptor	CHEBI:68643	2099	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of the cytotoxic agent estramustine_phosphate -LRB- Estracyt -RRB- with the estrogen_receptor of the human uterus .
15969240	0	estriol	11,18	insulin-like_growth_factor-I	63,91	estriol	insulin-like growth factor-I	MESH:D004964	3479	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of estriol on proliferative activity and expression of insulin-like_growth_factor-I -LRB- IGF-I -RRB- and IGF-I_receptor mRNA in cultured human osteoblast-like osteosarcoma cells .
8103274	0	estriol	94,101	ornithine_decarboxylase	27,50	estriol	ornithine decarboxylase	MESH:D004964	4953	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|induction induction|nmod|END_ENTITY	The induction of epidermal ornithine_decarboxylase following UV-B irradiation is inhibited by estriol .
18310281	0	estrogen	34,42	ABCC11	0,6	estrogen	ABCC11	MESH:D004967	85320	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|compound|END_ENTITY	ABCC11 expression is regulated by estrogen in MCF7 cells , correlated with estrogen_receptor_alpha expression in postmenopausal_breast_tumors and overexpressed in tamoxifen-resistant breast_cancer cells .
19851860	0	estrogen	25,33	ACAT1	5,10	estrogen	ACAT1	MESH:D004967	38	Chemical	Gene	cells|amod|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	High ACAT1 expression in estrogen receptor negative basal-like breast_cancer cells is associated with LDL-induced proliferation .
20849853	0	estrogen	23,31	ADAM10	64,70	estrogen	ADAM10	MESH:D004967	11487(Tax:10090)	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	EGCG functions through estrogen receptor-mediated activation of ADAM10 in the promotion of non-amyloidogenic processing of APP .
23977176	0	estrogen	77,85	ADAM10	104,110	estrogen	ADAM10	MESH:D004967	11487(Tax:10090)	Chemical	Gene	activation|amod|START_ENTITY activation|compound|END_ENTITY	Octyl_gallate markedly promotes anti-amyloidogenic processing of APP through estrogen receptor-mediated ADAM10 activation .
23669343	0	estrogen	43,51	AF-1	63,67	estrogen	AF-1	MESH:D004967	19185(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|dep|END_ENTITY	Tamoxifen elicits atheroprotection through estrogen receptor a AF-1 but does not accelerate reendothelialization .
8020488	0	estrogen	56,64	AIV	33,36	estrogen	AIV	MESH:D004967	11746(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Regulation of the apolipoprotein AIV gene expression by estrogen differs in rat and mouse .
16951146	0	estrogen	18,26	AKT	0,3	estrogen	AKT	MESH:D004967	207	Chemical	Gene	beta|amod|START_ENTITY regulation|nmod|beta regulation|compound|END_ENTITY	AKT regulation of estrogen receptor beta transcriptional activity in breast_cancer .
23844554	0	estrogen	126,134	AKT	68,71	estrogen	AKT	MESH:D004967	207	Chemical	Gene	deprivation|compound|START_ENTITY compensates|nmod|deprivation compensates|nmod|inhibition inhibition|nmod|END_ENTITY	Autocrine IGF-I/insulin receptor axis compensates for inhibition of AKT in ER-positive breast_cancer cells with resistance to estrogen deprivation .
25068805	0	estrogen	14,22	AKT	100,103	estrogen	AKT	MESH:D004967	207	Chemical	Gene	effect|nmod|START_ENTITY mediated|nsubjpass|effect mediated|nmod|END_ENTITY	The effect of estrogen on the proliferation of endometrial_cancer cells is mediated by ERRy through AKT and ERK1/2 .
22178929	0	estrogen	61,69	APP	53,56	estrogen	APP	MESH:D004967	54226(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	Ginsenoside_Rg1 promotes nonamyloidgenic cleavage of APP via estrogen receptor signaling to MAPK/ERK and PI3K/Akt .
10733498	0	estrogen	47,55	AR	93,95	estrogen	AR	MESH:D004967	367	Chemical	Gene	beta|compound|START_ENTITY beta|appos|END_ENTITY	Human megakaryocytes and platelets contain the estrogen receptor beta and androgen_receptor -LRB- AR -RRB- : testosterone regulates AR expression .
15048073	0	estrogen	53,61	Akt	66,69	estrogen	Akt	MESH:D004967	207	Chemical	Gene	START_ENTITY|nmod|cascade cascade|compound|END_ENTITY	Induction of hTERT expression and phosphorylation by estrogen via Akt cascade in human ovarian_cancer cell lines .
16971528	0	estrogen	228,236	Akt	111,114	estrogen	Akt	MESH:D004967	207	Chemical	Gene	action|compound|START_ENTITY mechanism|nmod|action 2|dep|mechanism interaction|dep|2 interaction|nmod|END_ENTITY	Estrogen_receptor protein interaction with phosphatidylinositol 3-kinase leads to activation of phosphorylated Akt and extracellular_signal-regulated_kinase_1 / 2 in the same population of cortical neurons : a unified mechanism of estrogen action .
17433823	0	estrogen	10,18	Akt	70,73	estrogen	Akt	MESH:D004967	24185(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|phosphatidylinositol-3_kinase phosphatidylinositol-3_kinase|nmod|END_ENTITY	Effect of estrogen and inhibition of phosphatidylinositol-3_kinase on Akt and FOXO1 in rat uterus .
17586659	0	estrogen	39,47	Akt	143,146	estrogen	Akt	MESH:D004967	24185(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY Mechanism|nmod|effects Mechanism|dep|up-regulation up-regulation|nmod|pathway pathway|compound|END_ENTITY	Mechanism of the nongenomic effects of estrogen on intestinal myeloperoxidase activity following trauma-hemorrhage : up-regulation of the PI-3K / Akt pathway .
18450422	0	estrogen	15,23	Akt	0,3	estrogen	Akt	MESH:D004967	207	Chemical	Gene	receptor|compound|START_ENTITY alpha|nsubj|receptor stabilizes|xcomp|alpha stabilizes|nsubj|END_ENTITY	Akt stabilizes estrogen receptor alpha with the concomitant reduction in its transcriptional activity .
19299741	0	estrogen	37,45	Akt	127,130	estrogen	Akt	MESH:D004967	11651(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY salutary|dep|effects capacity|amod|salutary Mechanism|nmod|capacity Mechanism|dep|role role|nmod|activation activation|compound|END_ENTITY	Mechanism of the salutary effects of estrogen on kupffer cell phagocytic capacity following trauma-hemorrhage : pivotal role of Akt activation .
23419388	0	estrogen	25,33	Akt	56,59	estrogen	Akt	MESH:D004967	207	Chemical	Gene	receptors|compound|START_ENTITY mediates|nmod|receptors mediates|nmod|END_ENTITY	Danshen mediates through estrogen receptors to activate Akt and inhibit apoptosis effect of Leu27IGF-II-induced IGF-II_receptor signaling activation in cardiomyoblasts .
23465388	0	estrogen	82,90	Akt	64,67	estrogen	Akt	MESH:D004967	24185(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY signaling|nmod|receptor signaling|compound|END_ENTITY	17b-Estradiol attenuates secondary injury through activation of Akt signaling via estrogen receptor alpha in rat brain following subarachnoid_hemorrhage .
24437944	0	estrogen	53,61	Akt	99,102	estrogen	Akt	MESH:D004967	24185(Tax:10116)	Chemical	Gene	crosstalk|amod|START_ENTITY crosstalk|nmod|pathways pathways|compound|END_ENTITY	Notoginsenoside_R1-mediated neuroprotection involves estrogen receptor-dependent crosstalk between Akt and ERK1/2 pathways : a novel mechanism of Nrf2/ARE signaling activation .
21258428	0	estrogen	22,30	Amphiregulin	0,12	estrogen	Amphiregulin	MESH:D004967	29183(Tax:10116)	Chemical	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	Amphiregulin mediates estrogen , progesterone , and EGFR signaling in the normal rat mammary gland and in hormone-dependent rat mammary cancers .
14734014	0	estrogen	140,148	Androgen_receptor	0,17	estrogen	Androgen receptor	MESH:D004967	367	Chemical	Gene	beta|amod|START_ENTITY mediated|nmod|beta mediated|nsubjpass|regulation regulation|amod|END_ENTITY	Androgen_receptor regulation by physiological concentrations of the isoflavonoid genistein in androgen-dependent LNCaP cells is mediated by estrogen receptor beta .
27026268	0	estrogen	82,90	Androgen_receptor	0,17	estrogen	Androgen receptor	MESH:D004967	367	Chemical	Gene	negative/HER2|amod|START_ENTITY expressed|nmod|negative/HER2 expressed|nsubjpass|END_ENTITY	Androgen_receptor and metastasis-associated protein-1 are frequently expressed in estrogen receptor negative/HER2 positive breast_cancer .
8496305	0	estrogen	136,144	Androgen_receptor	0,17	estrogen	Androgen receptor	MESH:D004967	367	Chemical	Gene	actions|nmod|START_ENTITY evidence|nmod|actions secretion|dep|evidence enhances|dobj|secretion enhances|nsubj|blockade blockade|amod|END_ENTITY	Androgen_receptor blockade with flutamide enhances growth hormone secretion in late pubertal males : evidence for independent actions of estrogen and androgen .
10703933	0	estrogen	50,58	Apolipoprotein_E	0,16	estrogen	Apolipoprotein E	MESH:D004967	348	Chemical	Gene	status|compound|START_ENTITY polymorphism|dep|status polymorphism|amod|END_ENTITY	Apolipoprotein_E gene polymorphism and bone_loss : estrogen status modifies the influence of apolipoprotein_E on bone_loss .
11522294	0	estrogen	91,99	Apolipoprotein_E	0,16	estrogen	Apolipoprotein E	MESH:D004967	348	Chemical	Gene	protection|nmod|START_ENTITY disruption|dep|protection disruption|amod|END_ENTITY	Apolipoprotein_E isoform-specific disruption of phosphoinositide hydrolysis : protection by estrogen and glutathione .
11882334	0	estrogen	73,81	Apolipoprotein_E	0,16	estrogen	Apolipoprotein E	MESH:D004967	348	Chemical	Gene	levels|nmod|START_ENTITY genotype|nmod|levels genotype|amod|END_ENTITY	Apolipoprotein_E genotype and response of lipid levels to postmenopausal estrogen use .
8932523	0	estrogen	79,87	Apolipoprotein_E	0,16	estrogen	Apolipoprotein E	MESH:D004967	11816(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Apolipoprotein_E gene expression in various tissues of mouse and regulation by estrogen .
22784990	0	estrogen	42,50	BAFF	7,11	estrogen	BAFF	MESH:D004967	24099(Tax:10090)	Chemical	Gene	up-regulated|nmod|START_ENTITY up-regulated|nsubjpass|expression expression|compound|END_ENTITY	Murine BAFF expression is up-regulated by estrogen and interferons : implications for sex bias in the development of autoimmunity .
23845438	0	estrogen	35,43	BCL-2	0,5	estrogen	BCL-2	MESH:D004967	596	Chemical	Gene	breast_cancer|amod|START_ENTITY target|nmod|breast_cancer END_ENTITY|dep|target	BCL-2 : a new therapeutic target in estrogen receptor-positive breast_cancer ?
17029253	0	estrogen	132,140	BDNF	155,159	estrogen	BDNF	MESH:D004967	24225(Tax:10116)	Chemical	Gene	modulation|compound|START_ENTITY modulation|nmod|END_ENTITY	Estradiol-induced modulation of estrogen receptor-beta and GABA within the adult neocortex : a potential transsynaptic mechanism for estrogen modulation of BDNF .
20453459	0	estrogen	26,34	BMP-7	0,5	estrogen	BMP-7	MESH:D004967	655	Chemical	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	BMP-7 in combination with estrogen enhances bone formation in a fracture callus explant culture .
11244506	0	estrogen	50,58	BRCA1	30,35	estrogen	BRCA1	MESH:D004967	672	Chemical	Gene	activity|amod|START_ENTITY Role|nmod|activity Role|nmod|inhibition inhibition|compound|END_ENTITY	Role of direct interaction in BRCA1 inhibition of estrogen receptor activity .
11782371	0	estrogen	39,47	BRCA1	19,24	estrogen	BRCA1	MESH:D004967	672	Chemical	Gene	activity|amod|START_ENTITY inhibition|nmod|activity inhibition|compound|END_ENTITY	p300 Modulates the BRCA1 inhibition of estrogen receptor activity .
15199145	0	estrogen	24,32	BRCA1	0,5	estrogen	BRCA1	MESH:D004967	672	Chemical	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	BRCA1 inhibits membrane estrogen and growth factor receptor signaling to cell proliferation in breast_cancer .
18405391	0	estrogen	14,22	BRCA1	64,69	estrogen	BRCA1	MESH:D004967	672	Chemical	Gene	beta|compound|START_ENTITY Expression|nmod|beta Expression|nmod|carriers carriers|compound|END_ENTITY	Expression of estrogen receptor beta in the breast_carcinoma of BRCA1 mutation carriers .
18997820	0	estrogen	80,88	BRCA1	10,15	estrogen	BRCA1	MESH:D004967	672	Chemical	Gene	interactions|amod|START_ENTITY altering|dobj|interactions confers|advcl|altering confers|nsubj|END_ENTITY	Decreased BRCA1 confers tamoxifen resistance in breast_cancer cells by altering estrogen receptor-coregulator interactions .
19435195	0	estrogen	44,52	BRCA1	123,128	estrogen	BRCA1	MESH:D004967	672	Chemical	Gene	4-hydroxylase|nmod:npmod|START_ENTITY 4-hydroxylase|nmod|tissues tissues|nmod|carriers carriers|compound|END_ENTITY	-LSB- An immunohistochemical study of aromatase , estrogen 4-hydroxylase and fatty_acid synthetase in breast cancer tissues from BRCA1 mutation carriers -RSB- .
19514368	0	estrogen	92,100	BRCA1	163,168	estrogen	BRCA1	MESH:D004967	672	Chemical	Gene	biosynthesis|compound|START_ENTITY involved|nmod|biosynthesis involved|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Analysis of polymorphisms in genes of insulin_receptor_substrate-1 and enzymes involved in estrogen biosynthesis and metabolism among breast_cancer patients with BRCA1 mutations -RSB- .
23203101	0	estrogen	19,27	BRCA1	13,18	estrogen	BRCA1	MESH:D004967	672	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	A DNA repair BRCA1 estrogen receptor and targeted therapy in breast_cancer .
24293149	0	estrogen	13,21	BRCA1	44,49	estrogen	BRCA1	MESH:D004967	672	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|region region|compound|END_ENTITY	Influence of estrogen and variations at the BRCA1 promoter region on transcription and translation .
26807247	0	estrogen	49,57	BRCA1	24,29	estrogen	BRCA1	MESH:D004967	672	Chemical	Gene	progesterone|compound|START_ENTITY tumors|compound|progesterone associated|nmod|tumors associated|nsubjpass|methylation methylation|nmod|END_ENTITY	Promoter methylation of BRCA1 is associated with estrogen , progesterone and human epidermal growth factor receptor-negative tumors and the prognosis of breast_cancer : A meta-analysis .
8895509	0	estrogen	98,106	BRCA1	0,5	estrogen	BRCA1	MESH:D004967	672	Chemical	Gene	elevated|nmod|START_ENTITY elevated|nsubj|levels levels|compound|END_ENTITY	BRCA1 and BRCA2 mRNA levels are coordinately elevated in human breast_cancer cells in response to estrogen .
9010238	0	estrogen	47,55	BRCA1	0,5	estrogen	BRCA1	MESH:D004967	672	Chemical	Gene	responsive|nmod|START_ENTITY responsive|nsubj|expression expression|compound|END_ENTITY	BRCA1 expression is not directly responsive to estrogen .
10800077	0	estrogen	72,80	Bcl-2	33,38	estrogen	Bcl-2	MESH:D004967	596	Chemical	Gene	status|compound|START_ENTITY patterns|nmod|status patterns|nmod|genes genes|compound|END_ENTITY	Different expression patterns of Bcl-2 family genes in breast_cancer by estrogen receptor status with special reference to pro-apoptotic Bak gene .
15909128	0	estrogen	34,42	Bcl-2	19,24	estrogen	Bcl-2	MESH:D004967	596	Chemical	Gene	action|amod|START_ENTITY cells|nsubj|action enhances|xcomp|cells enhances|nsubj|Down-regulation Down-regulation|nmod|END_ENTITY	Down-regulation of Bcl-2 enhances estrogen apoptotic action in long-term estradiol-depleted ER -LRB- + -RRB- breast_cancer cells .
16911782	0	estrogen	21,29	Bcl-2	55,60	estrogen	Bcl-2	MESH:D004967	596	Chemical	Gene	receptors|compound|START_ENTITY activity|appos|receptors END_ENTITY|nsubj|activity	Telomerase activity , estrogen receptors -LRB- alpha , beta -RRB- , Bcl-2 expression in human breast_cancer and treatment response .
17675494	0	estrogen	102,110	Bcl-2	17,22	estrogen	Bcl-2	MESH:D004967	596	Chemical	Gene	microenvironment|compound|START_ENTITY survival|nmod|microenvironment associated|nmod|survival associated|nsubjpass|Up-regulation Up-regulation|nmod|phosphorylation phosphorylation|amod|END_ENTITY	Up-regulation of Bcl-2 through ERK phosphorylation is associated with human macrophage survival in an estrogen microenvironment .
18342840	0	estrogen	28,36	Bcl-2	152,157	estrogen	Bcl-2	MESH:D004967	24224(Tax:10116)	Chemical	Gene	administration|nmod|START_ENTITY affords|nsubj|administration affords|xcomp|neuroprotection neuroprotection|xcomp|hippocampal hippocampal|advcl|modulating modulating|dobj|expression expression|nmod|END_ENTITY	Long-term administration of estrogen or tamoxifen to ovariectomized rats affords neuroprotection to hippocampal neurons by modulating the expression of Bcl-2 and Bax .
9721933	0	estrogen	57,65	Bcl-2	14,19	estrogen	Bcl-2	MESH:D004967	596	Chemical	Gene	protection|compound|START_ENTITY component|nmod|protection Modulation|dep|component Modulation|nmod|expression expression|compound|END_ENTITY	Modulation of Bcl-2 expression : a potential component of estrogen protection in NT2 neurons .
17653086	0	estrogen	14,22	Brca1	68,73	estrogen	Brca1	MESH:D004967	12189(Tax:10090)	Chemical	Gene	Activation|nmod|START_ENTITY collaborates|nsubj|Activation collaborates|nmod|loss loss|nmod|END_ENTITY	Activation of estrogen signaling pathways collaborates with loss of Brca1 to promote development of ERalpha-negative and ERalpha-positive mammary preneoplasia and cancer .
11398888	0	estrogen	61,69	C-erbB-2	0,8	estrogen	C-erbB-2	MESH:D004967	2064	Chemical	Gene	patients|amod|START_ENTITY subgroup|nmod|patients identifies|dobj|subgroup identifies|nsubj|overexpression overexpression|amod|END_ENTITY	C-erbB-2 oncoprotein overexpression identifies a subgroup of estrogen receptor positive -LRB- ER + -RRB- breast_cancer patients with poor prognosis .
24880122	0	estrogen	55,63	C-type_natriuretic_peptide	25,51	estrogen	C-type natriuretic peptide	MESH:D004967	4880	Chemical	Gene	response|nmod|START_ENTITY response|nmod|END_ENTITY	Differential response of C-type_natriuretic_peptide to estrogen and dexamethasone in adult bone .
11818112	0	estrogen	23,31	CA-125	56,62	estrogen	CA-125	MESH:D004967	94025	Chemical	Gene	administration|compound|START_ENTITY administration|nmod|END_ENTITY	Influence of exogenous estrogen administration on serum CA-125 originating from the endometrium .
15294932	0	estrogen	14,22	CD25	51,55	estrogen	CD25	MESH:D004967	16184(Tax:10090)	Chemical	Gene	expansion|amod|START_ENTITY expansion|nmod|compartment compartment|compound|END_ENTITY	Cutting edge : estrogen drives expansion of the CD4 + CD25 + regulatory T cell compartment .
15294932	0	estrogen	14,22	CD4	47,50	estrogen	CD4	MESH:D004967	12504(Tax:10090)	Chemical	Gene	expansion|amod|START_ENTITY expansion|nmod|compartment compartment|compound|END_ENTITY	Cutting edge : estrogen drives expansion of the CD4 + CD25 + regulatory T cell compartment .
1708703	0	estrogen	72,80	CD4	152,155	estrogen	CD4	MESH:D004967	12504(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	In vivo modulation of the distribution of thymocyte subsets : effects of estrogen on the expression of different T cell receptor V beta gene families in CD4 - , CD8 - thymocytes .
23827156	0	estrogen	11,19	CD4	23,26	estrogen	CD4	MESH:D004967	920	Chemical	Gene	START_ENTITY|nmod|CD25 CD25|compound|END_ENTITY	Effects of estrogen on CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cell in peripheral blood during pregnancy .
26298324	0	estrogen	14,22	CD4	49,52	estrogen	CD4	MESH:D004967	12504(Tax:10090)	Chemical	Gene	synergy|compound|START_ENTITY synergy|nmod|T T|compound|END_ENTITY	Vitamin_D and estrogen synergy in Vdr-expressing CD4 -LRB- + -RRB- T cells is essential to induce Helios -LRB- + -RRB- FoxP3 -LRB- + -RRB- T cells and prevent autoimmune demyelinating_disease .
11245479	0	estrogen	33,41	CGA	18,21	estrogen	CGA	MESH:D004967	1113	Chemical	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification of CGA as a novel estrogen receptor-responsive gene in breast_cancer : an outstanding candidate marker to predict the response to endocrine therapy .
18164902	0	estrogen	32,40	COMT	71,75	estrogen	COMT	MESH:D004967	1312	Chemical	Gene	genes|amod|START_ENTITY genes|appos|ESR1 ESR1|dep|END_ENTITY	Analyses of variants located in estrogen metabolism genes -LRB- ESR1 , ESR2 , COMT and APOE -RRB- and schizophrenia .
17674191	0	estrogen	19,27	COUP-TFI	0,8	estrogen	COUP-TFI	MESH:D004967	7025	Chemical	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	COUP-TFI modulates estrogen signaling and influences proliferation , survival and migration of breast_cancer cells .
19351702	0	estrogen	112,120	CR1	124,127	estrogen	CR1	MESH:D004967	12902(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Enhanced susceptibility to low-dose collagen-induced_arthritis in CR1/2-deficient female mice -- possible role of estrogen on CR1 expression .
17646279	0	estrogen	27,35	CYP2A6	6,12	estrogen	CYP2A6	MESH:D004967	1548	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Human CYP2A6 is induced by estrogen via estrogen_receptor .
9264551	0	estrogen	40,48	CYP3A9	14,20	estrogen	CYP3A9	MESH:D004967	171352(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Regulation of CYP3A9 gene expression by estrogen and catalytic studies using cytochrome P450 3A9 expressed in Escherichia_coli .
11672838	0	estrogen	10,18	Cry1	40,44	estrogen	Cry1	MESH:D004967	299691(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effect of estrogen on the expression of Cry1 and Cry2 mRNAs in the suprachiasmatic nucleus of female rats .
12469160	0	estrogen	68,76	Cyclin_D1	0,9	estrogen	Cyclin D1	MESH:D004967	595	Chemical	Gene	receptor|compound|START_ENTITY therapy|nmod|receptor expression|nmod|therapy expression|amod|END_ENTITY	Cyclin_D1 expression and patient outcome after tamoxifen therapy in estrogen receptor positive metastatic breast_cancer .
20338923	0	estrogen	28,36	Cyclin_D1	0,9	estrogen	Cyclin D1	MESH:D004967	12443(Tax:10090)	Chemical	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Cyclin_D1 regulates hepatic estrogen and androgen metabolism .
20404095	0	estrogen	35,43	Cyclin_D1	0,9	estrogen	Cyclin D1	MESH:D004967	12443(Tax:10090)	Chemical	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	Cyclin_D1 enhances the response to estrogen and progesterone by regulating progesterone_receptor expression .
21628965	0	estrogen	16,24	Cyclin_D1	0,9	estrogen	Cyclin D1	MESH:D004967	58919(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY cdk4|appos|receptors END_ENTITY|dep|cdk4	Cyclin_D1 / cdk4 , estrogen receptors a and b , in N-methyl-N ' - nitro-N-nitrosoguanidine-induced rat gastric_carcinogenesis : immunohistochemical study .
23060014	0	estrogen	44,52	Cyclin_D1	0,9	estrogen	Cyclin D1	MESH:D004967	595	Chemical	Gene	beta|compound|START_ENTITY involved|nmod|beta involved|nsubjpass|expression expression|amod|END_ENTITY	Cyclin_D1 -LRB- CCND1 -RRB- expression is involved in estrogen receptor beta -LRB- ERb -RRB- in human prostate_cancer .
23864650	0	estrogen	21,29	Cyclin_D1	0,9	estrogen	Cyclin D1	MESH:D004967	595	Chemical	Gene	determines|dobj|START_ENTITY determines|nsubj|END_ENTITY	Cyclin_D1 determines estrogen signaling in the mammary gland in vivo .
19423554	0	estrogen	38,46	DYX1C1	26,32	estrogen	DYX1C1	MESH:D004967	363096(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY END_ENTITY|nmod|receptors	Functional interaction of DYX1C1 with estrogen receptors suggests involvement of hormonal pathways in dyslexia .
22383464	0	estrogen	91,99	DYX1C1	81,87	estrogen	DYX1C1	MESH:D004967	161582	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	The rs3743205 SNP is important for the regulation of the dyslexia candidate gene DYX1C1 by estrogen receptor b and DNA methylation .
12138142	0	estrogen	61,69	ECaC1	91,96	estrogen	ECaC1	MESH:D004967	56302	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	1,25-dihydroxyvitamin _ D -LRB- 3 -RRB- - independent stimulatory effect of estrogen on the expression of ECaC1 in the kidney .
8641283	0	estrogen	29,37	EGF	50,53	estrogen	EGF	MESH:D004967	1950	Chemical	Gene	receptor|compound|START_ENTITY receptor|nmod|END_ENTITY	Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation .
16033082	0	estrogen	69,77	ER-alpha	94,102	estrogen	ER-alpha	MESH:D004967	2099	Chemical	Gene	alpha|compound|START_ENTITY alpha|appos|END_ENTITY	Normal and malignant human endometrium express immunohistochemically estrogen receptor alpha -LRB- ER-alpha -RRB- , estrogen receptor beta -LRB- ER-beta -RRB- and progesterone_receptor -LRB- PR -RRB- .
9329394	0	estrogen	23,31	ER-alpha	49,57	estrogen	ER-alpha	MESH:D004967	2099	Chemical	Gene	alpha|amod|START_ENTITY alpha|appos|END_ENTITY	Tissue distribution of estrogen receptors alpha -LRB- ER-alpha -RRB- and beta _ -LRB- ER-beta -RRB- mRNA in the midgestational human fetus .
9800279	0	estrogen	28,36	ER-alpha	53,61	estrogen	ER-alpha	MESH:D004967	24890(Tax:10116)	Chemical	Gene	receptor-alpha|compound|START_ENTITY receptor-alpha|appos|END_ENTITY	Comparative distribution of estrogen receptor-alpha -LRB- ER-alpha -RRB- and beta _ -LRB- ER-beta -RRB- mRNA in the rat pituitary , gonad , and reproductive tract .
24704270	0	estrogen	81,89	ER-b	105,109	estrogen	ER-b	MESH:D004967	2100	Chemical	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Increased steroid_receptor_RNA_activator_protein -LRB- SRAP -RRB- accompanied by decreased estrogen receptor-beta -LRB- ER-b -RRB- levels during the malignant_transformation_of_endometriosis associated ovarian_clear_cell_carcinoma .
16033082	0	estrogen	105,113	ER-beta	129,136	estrogen	ER-beta	MESH:D004967	2100	Chemical	Gene	beta|compound|START_ENTITY beta|appos|END_ENTITY	Normal and malignant human endometrium express immunohistochemically estrogen receptor alpha -LRB- ER-alpha -RRB- , estrogen receptor beta -LRB- ER-beta -RRB- and progesterone_receptor -LRB- PR -RRB- .
15184047	0	estrogen	108,116	ERK1/2	134,140	estrogen	ERK1/2	MESH:D004967	5595;5594	Chemical	Gene	stimulates|compound|START_ENTITY stimulates|dep|activation activation|compound|END_ENTITY	Estrogen_receptor expression in a human primitive neuroectodermal_tumor cell line from the cerebral cortex : estrogen stimulates rapid ERK1/2 activation and receptor-dependent cell migration .
15642162	0	estrogen	9,17	ERK1/2	65,71	estrogen	ERK1/2	MESH:D004967	5595;5594	Chemical	Gene	levels|compound|START_ENTITY predict|nsubj|levels predict|dobj|activation activation|compound|END_ENTITY	Membrane estrogen receptor-alpha levels predict estrogen-induced ERK1/2 activation in MCF-7 cells .
19275968	0	estrogen	12,20	ERK1/2	91,97	estrogen	ERK1/2	MESH:D004967	531391;327672	Chemical	Gene	modulator|compound|START_ENTITY inhibits|nsubj|modulator inhibits|advcl|activating activating|dobj|END_ENTITY	A selective estrogen receptor modulator inhibits TNF-alpha-induced apoptosis by activating ERK1/2 signaling pathway in vascular endothelial cells .
22480687	0	estrogen	12,20	ERK1/2	103,109	estrogen	ERK1/2	MESH:D004967	5595;5594	Chemical	Gene	modulator|compound|START_ENTITY inhibits|nsubj|modulator inhibits|ccomp|necrosis necrosis|nmod|END_ENTITY	A selective estrogen receptor modulator inhibits tumor necrosis factor-a-induced apoptosis through the ERK1/2 signaling pathway in human chondrocytes .
24231043	0	estrogen	76,84	ERK1/2	103,109	estrogen	ERK1/2	MESH:D004967	50689;116590	Chemical	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Bisphenol_A promotes dendritic morphogenesis of hippocampal neurons through estrogen receptor-mediated ERK1/2 signal pathway .
25753185	0	estrogen	32,40	ERK1/2	130,136	estrogen	ERK1/2	MESH:D004967	5595;5594	Chemical	Gene	receptor|compound|START_ENTITY coupled|dobj|receptor G-protein|acl|coupled Activation|nmod|G-protein inhibits|nsubj|Activation inhibits|dobj|proliferation proliferation|nmod|cells cells|nmod|activation activation|nmod|END_ENTITY	Activation of G-protein coupled estrogen receptor inhibits the proliferation of cervical_cancer cells via sustained activation of ERK1/2 .
12185669	0	estrogen	14,22	ERR	3,6	estrogen	ERR	MESH:D004967	6541	Chemical	Gene	pathway|compound|START_ENTITY END_ENTITY|nmod|pathway	To ERR in the estrogen pathway .
11381083	0	estrogen	19,27	ERRalpha	61,69	estrogen	ERRalpha	MESH:D004967	293701(Tax:10116)	Chemical	Gene	alpha|compound|START_ENTITY alpha|appos|END_ENTITY	The orphan nuclear estrogen receptor-related receptor alpha -LRB- ERRalpha -RRB- is expressed throughout osteoblast differentiation and regulates bone formation in vitro .
9415404	0	estrogen	11,19	ER_alpha	38,46	estrogen	ER alpha	MESH:D004967	2099	Chemical	Gene	isoform|amod|START_ENTITY isoform|appos|END_ENTITY	Loss of an estrogen receptor isoform -LRB- ER_alpha delta 3 -RRB- in breast_cancer and the consequences of its reexpression : interference with estrogen-stimulated properties of malignant transformation .
11530282	0	estrogen	58,66	ER_beta	82,89	estrogen	ER beta	MESH:D004967	2100	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The multiple untranslated first exons system of the human estrogen receptor beta -LRB- ER_beta -RRB- gene .
8769313	0	estrogen	62,70	ER_beta	0,7	estrogen	ER beta	MESH:D004967	2100	Chemical	Gene	receptor|compound|START_ENTITY identification|nmod|receptor END_ENTITY|dep|identification	ER_beta : identification and characterization of a novel human estrogen receptor .
9794460	0	estrogen	38,46	ER_beta	70,77	estrogen	ER beta	MESH:D004967	2100	Chemical	Gene	beta|amod|START_ENTITY beta|appos|END_ENTITY	Transcription activation by the human estrogen receptor subtype beta -LRB- ER_beta -RRB- studied with ER_beta and ER_alpha receptor chimeras .
9794460	0	estrogen	38,46	ER_beta	92,99	estrogen	ER beta	MESH:D004967	2100	Chemical	Gene	beta|amod|START_ENTITY activation|nmod|beta studied|nsubj|activation studied|nmod|chimeras chimeras|compound|END_ENTITY	Transcription activation by the human estrogen receptor subtype beta -LRB- ER_beta -RRB- studied with ER_beta and ER_alpha receptor chimeras .
20958252	0	estrogen	14,22	ERa	54,57	estrogen	ERa	MESH:D004967	26284	Chemical	Gene	disruptors|compound|START_ENTITY Pesticides|nmod|disruptors Pesticides|dep|QSAR QSAR|nmod|END_ENTITY	Pesticides as estrogen disruptors : QSAR for selective ERa and ERb binding of pesticides .
22282469	0	estrogen	82,90	ERa	115,118	estrogen	ERa	MESH:D004967	13982(Tax:10090)	Chemical	Gene	maintenance|nmod|START_ENTITY required|nmod|maintenance required|xcomp|signaling signaling|dobj|mechanism mechanism|nmod|END_ENTITY	Nucleolar Sik-similar_protein -LRB- Sik-SP -RRB- is required for the maintenance of uterine estrogen signaling mechanism via ERa .
22328528	0	estrogen	95,103	ERa	15,18	estrogen	ERa	MESH:D004967	2099	Chemical	Gene	transcription|amod|START_ENTITY essential|nmod|transcription essential|csubj|Binding Binding|nmod|END_ENTITY	Binding of the ERa and ARNT1 AF2 domains to exon 21 of the SRC1 isoform SRC1e is essential for estrogen - and dioxin-related transcription .
22347418	0	estrogen	18,26	ERa	119,122	estrogen	ERa	MESH:D004967	2099	Chemical	Gene	ligands|amod|START_ENTITY Identification|nmod|ligands reveals|nsubj|Identification reveals|nmod|cells cells|acl:relcl|co-express co-express|dobj|END_ENTITY	Identification of estrogen receptor dimer selective ligands reveals growth-inhibitory effects on cells that co-express ERa and ERb .
22787479	0	estrogen	50,58	ERa	70,73	estrogen	ERa	MESH:D004967	13982(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY types|nmod|receptors Functions|nmod|types Functions|amod|END_ENTITY	Functions and physiological roles of two types of estrogen receptors , ERa and ERb , identified by estrogen receptor knockout mouse .
22787479	0	estrogen	97,105	ERa	70,73	estrogen	ERa	MESH:D004967	13982(Tax:10090)	Chemical	Gene	mouse|amod|START_ENTITY identified|nmod|mouse identified|nsubj|Functions Functions|amod|END_ENTITY	Functions and physiological roles of two types of estrogen receptors , ERa and ERb , identified by estrogen receptor knockout mouse .
23266443	0	estrogen	54,62	ERa	46,49	estrogen	ERa	MESH:D004967	2099	Chemical	Gene	b1|amod|START_ENTITY estrogen_receptor_a|dep|b1 estrogen_receptor_a|appos|END_ENTITY	The expression ratios of estrogen_receptor_a -LRB- ERa -RRB- to estrogen receptor b1 -LRB- ERb1 -RRB- and ERa to ERb2 identify poor clinical outcome in endometrioid_endometrial_cancer .
23860318	0	estrogen	9,17	ERa	120,123	estrogen	ERa	MESH:D004967	2099	Chemical	Gene	responsive|amod|START_ENTITY element|amod|responsive element|nsubj|element element|nmod|transactivation transactivation|compound|END_ENTITY	A distal estrogen responsive element upstream the cap site of human transthyretin gene is an enhancer-like element upon ERa and/or ERb transactivation .
24446390	0	estrogen	8,16	ERa	134,137	estrogen	ERa	MESH:D004967	2099	Chemical	Gene	GPER|compound|START_ENTITY mediates|nsubj|GPER mediates|dobj|proliferation proliferation|acl|induced induced|nmod|estrogen_receptor_a estrogen_receptor_a|appos|END_ENTITY	A novel estrogen receptor GPER mediates proliferation induced by 17b-estradiol and selective GPER agonist G-1 in estrogen_receptor_a -LRB- ERa -RRB- - negative ovarian_cancer cells .
24819599	0	estrogen	10,18	ERa	38,41	estrogen	ERa	MESH:D004967	2099	Chemical	Gene	subtypes|compound|START_ENTITY subtypes|appos|END_ENTITY	Targeting estrogen receptor subtypes -LRB- ERa and ERb -RRB- with selective ER modulators in ovarian_cancer .
24923734	0	estrogen	52,60	ERa	100,103	estrogen	ERa	MESH:D004967	26284	Chemical	Gene	receptors|compound|START_ENTITY receptors|nmod|coregulators coregulators|acl|induced induced|nmod|END_ENTITY	Cell proliferation and modulation of interaction of estrogen receptors with coregulators induced by ERa and ERb agonists .
25117411	0	estrogen	14,22	ERa	40,43	estrogen	ERa	MESH:D004967	13982(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY requires|nsubj|effect requires|dobj|END_ENTITY	The effect of estrogen on bone requires ERa in nonhematopoietic_cells but is enhanced by ERa in hematopoietic cells .
25980457	0	estrogen	16,24	ERa	44,47	estrogen	ERa	MESH:D004967	13982(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY Contribution|nmod|receptor subtypes|nsubj|Contribution subtypes|dep|END_ENTITY	Contribution of estrogen receptor subtypes , ERa , ERb , and GPER1 in rapid estradiol-mediated enhancement of hippocampal synaptic transmission in mice .
26522726	0	estrogen	54,62	ERa	45,48	estrogen	ERa	MESH:D004967	2099	Chemical	Gene	stimulation|compound|START_ENTITY END_ENTITY|nmod|stimulation	mTORC1 directly phosphorylates and activates ERa upon estrogen stimulation .
26598695	6	estrogen	1181,1189	ERa	1202,1205	estrogen	ERa	MESH:D004967	2099	Chemical	Gene	START_ENTITY|xcomp|activity activity|appos|END_ENTITY	The neonatal phase of penile development is controlled by the balance of AR to estrogen receptor a -LRB- ERa -RRB- activity ; either inhibition of androgen or augmentation of estrogen signaling can induce micropenis .
26598695	6	estrogen	1266,1274	ERa	1202,1205	estrogen	ERa	MESH:D004967	2099	Chemical	Gene	signaling|compound|START_ENTITY androgen|nmod|signaling inhibition|nmod|androgen induce|nsubj|inhibition controlled|parataxis|induce controlled|xcomp|estrogen estrogen|xcomp|activity activity|appos|END_ENTITY	The neonatal phase of penile development is controlled by the balance of AR to estrogen receptor a -LRB- ERa -RRB- activity ; either inhibition of androgen or augmentation of estrogen signaling can induce micropenis .
10213481	0	estrogen	39,47	ERalpha	58,65	estrogen	ERalpha	MESH:D004967	24890(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Stable transfection of PC12 cells with estrogen receptor -LRB- ERalpha -RRB- : protective effects of estrogen on cell survival after serum deprivation .
10213481	0	estrogen	90,98	ERalpha	58,65	estrogen	ERalpha	MESH:D004967	24890(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY transfection|dep|effects transfection|nmod|cells cells|nmod|receptor receptor|appos|END_ENTITY	Stable transfection of PC12 cells with estrogen receptor -LRB- ERalpha -RRB- : protective effects of estrogen on cell survival after serum deprivation .
10537130	0	estrogen	86,94	ERalpha	111,118	estrogen	ERalpha	MESH:D004967	24890(Tax:10116)	Chemical	Gene	receptor-alpha|compound|START_ENTITY expression|nmod|receptor-alpha gene|acl|expression gene|appos|END_ENTITY	Estrogen directly respresses gonadotropin-releasing_hormone -LRB- GnRH -RRB- gene expression in estrogen receptor-alpha -LRB- ERalpha -RRB- - and ERbeta-expressing GT1-7 GnRH neurons .
10579320	0	estrogen	4,12	ERalpha	85,92	estrogen	ERalpha	MESH:D004967	2099	Chemical	Gene	beta-isoform|amod|START_ENTITY modulates|nsubj|beta-isoform modulates|dobj|activity activity|compound|END_ENTITY	The estrogen receptor beta-isoform -LRB- ERbeta -RRB- of the human estrogen receptor modulates ERalpha transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens .
10579320	0	estrogen	57,65	ERalpha	85,92	estrogen	ERalpha	MESH:D004967	2099	Chemical	Gene	receptor|compound|START_ENTITY beta-isoform|nmod|receptor modulates|nsubj|beta-isoform modulates|dobj|activity activity|compound|END_ENTITY	The estrogen receptor beta-isoform -LRB- ERbeta -RRB- of the human estrogen receptor modulates ERalpha transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens .
10830306	0	estrogen	100,108	ERalpha	119,126	estrogen	ERalpha	MESH:D004967	24890(Tax:10116)	Chemical	Gene	decreases|compound|START_ENTITY decreases|dep|protein protein|compound|END_ENTITY	Differential expression and regulation of estrogen receptors -LRB- ERs -RRB- in rat pituitary and cell lines : estrogen decreases ERalpha protein and estrogen responsiveness .
10830306	0	estrogen	42,50	ERalpha	119,126	estrogen	ERalpha	MESH:D004967	24890(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY expression|nmod|receptors expression|dep|decreases decreases|dep|protein protein|compound|END_ENTITY	Differential expression and regulation of estrogen receptors -LRB- ERs -RRB- in rat pituitary and cell lines : estrogen decreases ERalpha protein and estrogen responsiveness .
11060287	0	estrogen	77,85	ERalpha	97,104	estrogen	ERalpha	MESH:D004967	2099	Chemical	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Unique protein determinants of the subtype-selective ligand responses of the estrogen receptors -LRB- ERalpha and ERbeta -RRB- at AP-1 sites .
11162434	0	estrogen	3,11	ERalpha	91,98	estrogen	ERalpha	MESH:D004967	2099	Chemical	Gene	isoform|amod|START_ENTITY has|nsubj|isoform has|dobj|activity activity|nmod|END_ENTITY	An estrogen receptor beta isoform that lacks exon 5 has dominant negative activity on both ERalpha and ERbeta .
11358690	0	estrogen	36,44	ERalpha	56,63	estrogen	ERalpha	MESH:D004967	24890(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY activation|nmod|receptors activation|appos|END_ENTITY	Differential SERM activation of the estrogen receptors -LRB- ERalpha and ERbeta -RRB- at AP-1 sites .
11850023	0	estrogen	30,38	ERalpha	55,62	estrogen	ERalpha	MESH:D004967	24890(Tax:10116)	Chemical	Gene	receptor-alpha|compound|START_ENTITY receptor-alpha|appos|END_ENTITY	Age differentially influences estrogen receptor-alpha -LRB- ERalpha -RRB- and estrogen receptor-beta -LRB- ERbeta -RRB- gene expression in specific regions of the rat brain .
12399409	0	estrogen	48,56	ERalpha	68,75	estrogen	ERalpha	MESH:D004967	24890(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Characterization of the biological roles of the estrogen receptors , ERalpha and ERbeta , in estrogen target tissues in vivo through the use of an ERalpha-selective ligand .
12399409	0	estrogen	91,99	ERalpha	68,75	estrogen	ERalpha	MESH:D004967	24890(Tax:10116)	Chemical	Gene	receptors|nmod|START_ENTITY receptors|appos|END_ENTITY	Characterization of the biological roles of the estrogen receptors , ERalpha and ERbeta , in estrogen target tissues in vivo through the use of an ERalpha-selective ligand .
12399412	0	estrogen	61,69	ERalpha	25,32	estrogen	ERalpha	MESH:D004967	13982(Tax:10090)	Chemical	Gene	stimulation|compound|START_ENTITY modulates|dobj|stimulation modulates|nsubj|Estrogen_receptor-alpha Estrogen_receptor-alpha|appos|END_ENTITY	Estrogen_receptor-alpha -LRB- ERalpha -RRB- , but not ERbeta , modulates estrogen stimulation of the ERalpha-truncated variant , TERP-1 .
12624116	0	estrogen	63,71	ERalpha	164,171	estrogen	ERalpha	MESH:D004967	13982(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY hypothalamic-pituitary-gonadal_axis|nmod|receptor mice|amod|hypothalamic-pituitary-gonadal_axis Characterization|nmod|mice reveals|nsubj|Characterization reveals|dobj|reversal reversal|nmod|females females|acl|lacking lacking|dobj|END_ENTITY	Characterization of the hypothalamic-pituitary-gonadal_axis in estrogen receptor -LRB- ER -RRB- Null mice reveals hypergonadism and endocrine sex reversal in females lacking ERalpha but not ERbeta .
12667452	0	estrogen	122,130	ERalpha	64,71	estrogen	ERalpha	MESH:D004967	26284	Chemical	Gene	feature|nmod|START_ENTITY feature|nsubj|turnover turnover|nmod|END_ENTITY	Cyclic , proteasome-mediated turnover of unliganded and liganded ERalpha on responsive promoters is an integral feature of estrogen signaling .
12790809	0	estrogen	30,38	ERalpha	49,56	estrogen	ERalpha	MESH:D004967	2099	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Transcriptional activation by estrogen receptor -LRB- ERalpha -RRB- and steroid_receptor_coactivator -LRB- SRC1 -RRB- involves distinct mechanisms in yeast and mammalian cells .
12810552	0	estrogen	35,43	ERalpha	143,150	estrogen	ERalpha	MESH:D004967	2099	Chemical	Gene	receptor|compound|START_ENTITY variant|nmod|receptor suppresses|nsubj|variant suppresses|nmod|END_ENTITY	The naturally occurring variant of estrogen receptor -LRB- ER -RRB- ERDeltaE7 suppresses estrogen-dependent transcriptional activation by both wild-type ERalpha and ERbeta .
14680815	0	estrogen	103,111	ERalpha	62,69	estrogen	ERalpha	MESH:D004967	2099	Chemical	Gene	ligand|compound|START_ENTITY blocked|nmod|ligand blocked|nsubjpass|functions functions|nmod|END_ENTITY	Both N - and C-terminal transactivation functions of DNA-bound ERalpha are blocked by a novel synthetic estrogen ligand .
15171726	0	estrogen	16,24	ERalpha	104,111	estrogen	ERalpha	MESH:D004967	259252(Tax:7955)	Chemical	Gene	regulation|compound|START_ENTITY Analysis|nmod|regulation reveals|nsubj|Analysis reveals|dobj|effects effects|nmod|END_ENTITY	Analysis of the estrogen regulation of the zebrafish estrogen receptor -LRB- ER -RRB- reveals distinct effects of ERalpha , ERbeta1 and ERbeta2 .
15171726	0	estrogen	53,61	ERalpha	104,111	estrogen	ERalpha	MESH:D004967	259252(Tax:7955)	Chemical	Gene	receptor|compound|START_ENTITY regulation|nmod|receptor Analysis|nmod|regulation reveals|nsubj|Analysis reveals|dobj|effects effects|nmod|END_ENTITY	Analysis of the estrogen regulation of the zebrafish estrogen receptor -LRB- ER -RRB- reveals distinct effects of ERalpha , ERbeta1 and ERbeta2 .
15205556	0	estrogen	29,37	ERalpha	48,55	estrogen	ERalpha	MESH:D004967	24890(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY receptors|nsubj|role receptors|dobj|END_ENTITY	Biological role of pituitary estrogen receptors ERalpha and ERbeta on progesterone_receptor expression and action and on gonadotropin and prolactin secretion in the rat .
15314175	0	estrogen	13,21	ERalpha	105,112	estrogen	ERalpha	MESH:D004967	2099	Chemical	Gene	receptors|compound|START_ENTITY reveal|nsubj|receptors reveal|ccomp|emulates emulates|dobj|functions functions|nmod|dimer dimer|compound|END_ENTITY	Single-chain estrogen receptors -LRB- ERs -RRB- reveal that the ERalpha/beta heterodimer emulates functions of the ERalpha dimer in genomic estrogen signaling pathways .
15314175	0	estrogen	130,138	ERalpha	105,112	estrogen	ERalpha	MESH:D004967	2099	Chemical	Gene	emulates|nmod|START_ENTITY emulates|dobj|functions functions|nmod|dimer dimer|compound|END_ENTITY	Single-chain estrogen receptors -LRB- ERs -RRB- reveal that the ERalpha/beta heterodimer emulates functions of the ERalpha dimer in genomic estrogen signaling pathways .
15530885	0	estrogen	99,107	ERalpha	119,126	estrogen	ERalpha	MESH:D004967	13982(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Estrogen attenuates the MPTP-induced loss of dopamine neurons from the mouse SNc despite a lack of estrogen receptors -LRB- ERalpha and ERbeta -RRB- .
15821115	0	estrogen	29,37	ERalpha	77,84	estrogen	ERalpha	MESH:D004967	2099	Chemical	Gene	START_ENTITY|acl:relcl|re-express re-express|dobj|END_ENTITY	Anti-proliferative effect of estrogen in breast_cancer cells that re-express ERalpha is mediated by aberrant regulation of cell cycle genes .
15993498	0	estrogen	41,49	ERalpha	85,92	estrogen	ERalpha	MESH:D004967	2099	Chemical	Gene	isoforms|amod|START_ENTITY distribution|nmod|isoforms distribution|dep|localization localization|nmod|END_ENTITY	Differential subcellular distribution of estrogen receptor isoforms : localization of ERalpha in the nucleoli and ERbeta in the mitochondria of human osteosarcoma SaOS-2 and hepatocarcinoma HepG2 cell lines .
16190622	0	estrogen	73,81	ERalpha	100,107	estrogen	ERalpha	MESH:D004967	2099	Chemical	Gene	receptor|compound|START_ENTITY ellagic_acid|nmod|receptor activity|nmod|ellagic_acid Evaluation|nmod|activity subtypes|nsubj|Evaluation subtypes|dobj|END_ENTITY	Evaluation of estrogenic/antiestrogenic activity of ellagic_acid via the estrogen receptor subtypes ERalpha and ERbeta .
16527848	0	estrogen	27,35	ERalpha	89,96	estrogen	ERalpha	MESH:D004967	2099	Chemical	Gene	receptors|compound|START_ENTITY modulation|nmod|receptors modulation|dep|role role|nmod|END_ENTITY	Differential modulation of estrogen receptors -LRB- ERs -RRB- in ischemic_brain_injury : a role for ERalpha in estradiol-mediated protection against delayed cell death .
16869728	0	estrogen	102,110	ERalpha	70,77	estrogen	ERalpha	MESH:D004967	24890(Tax:10116)	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|content content|compound|END_ENTITY	Osteocytes use estrogen receptor alpha to respond to strain but their ERalpha content is regulated by estrogen .
16919388	0	estrogen	21,29	ERalpha	46,53	estrogen	ERalpha	MESH:D004967	398734(Tax:8355)	Chemical	Gene	alpha|amod|START_ENTITY cloning|nmod|alpha cloning|appos|END_ENTITY	Molecular cloning of estrogen receptor alpha -LRB- ERalpha ; ESR1 -RRB- of the Japanese_giant_salamander , Andrias_japonicus .
17320868	0	estrogen	19,27	ERalpha	86,93	estrogen	ERalpha	MESH:D004967	13982(Tax:10090)	Chemical	Gene	Neuroprotection|nmod|START_ENTITY Neuroprotection|parataxis|mediated mediated|nmod|END_ENTITY	Neuroprotection by estrogen against MPP + - induced dopamine neuron death is mediated by ERalpha in primary cultures of mouse mesencephalon .
19179608	0	estrogen	50,58	ERalpha	91,98	estrogen	ERalpha	MESH:D004967	2099	Chemical	Gene	responsiveness|compound|START_ENTITY reduces|dobj|responsiveness reduces|nmod|expression expression|compound|END_ENTITY	Prolactin-growth factor crosstalk reduces mammary estrogen responsiveness despite elevated ERalpha expression .
19299445	0	estrogen	66,74	ERalpha	25,32	estrogen	ERalpha	MESH:D004967	2099	Chemical	Gene	effects|nmod|START_ENTITY mediates|dobj|effects mediates|nsubj|Estrogen_receptor_alpha Estrogen_receptor_alpha|appos|END_ENTITY	Estrogen_receptor_alpha -LRB- ERalpha -RRB- mediates stimulatory effects of estrogen on aromatase -LRB- CYP19 -RRB- gene expression in human placenta .
19635557	0	estrogen	45,53	ERalpha	65,72	estrogen	ERalpha	MESH:D004967	2099	Chemical	Gene	START_ENTITY|dobj|effects effects|nmod|END_ENTITY	High glucose-induced oxidative stress alters estrogen effects on ERalpha and ERbeta in human endothelial cells : reversal by AMPK activator .
19942713	10	estrogen	1584,1592	ERalpha	1637,1644	estrogen	ERalpha	MESH:D004967	2099	Chemical	Gene	mediating|nmod|START_ENTITY mechanisms|acl|mediating suggested|nsubjpass|mechanisms suggested|xcomp|limitation limitation|nmod|levels levels|compound|END_ENTITY	The molecular mechanisms mediating this inhibitory effect of ICB-1 on estrogen signaling are suggested to be limitation of ERalpha transcript levels but sustaining high levels of ERbeta , reducing both activation of ERalpha target genes and cellular proliferation .
20599505	0	estrogen	20,28	ERalpha	48,55	estrogen	ERalpha	MESH:D004967	2099	Chemical	Gene	impact|nmod|START_ENTITY impact|acl|signalling signalling|nmod|END_ENTITY	Metabolic impact of estrogen signalling through ERalpha and ERbeta .
21972702	0	estrogen	21,29	ERalpha	41,48	estrogen	ERalpha	MESH:D004967	2099	Chemical	Gene	receptors|compound|START_ENTITY value|nmod|receptors value|dep|END_ENTITY	-LSB- Prognostic value of estrogen receptors -- ERalpha and ERbeta , in patients with lung_cancer -RSB- .
25300391	0	estrogen	55,63	ERalpha	12,19	estrogen	ERalpha	MESH:D004967	2099	Chemical	Gene	agonism|compound|START_ENTITY Evidence|dep|agonism Evidence|nmod|END_ENTITY	Evidence of ERalpha and ERbeta selectivity and partial estrogen agonism in traditional Chinese medicine .
9733072	0	estrogen	52,60	ERalpha	72,79	estrogen	ERalpha	MESH:D004967	24890(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Expression and neuropeptidergic characterization of estrogen receptors -LRB- ERalpha and ERbeta -RRB- throughout the rat brain : anatomical evidence of distinct roles of each subtype .
21344398	0	estrogen	58,66	ERb	82,85	estrogen	ERb	MESH:D004967	2100	Chemical	Gene	beta|compound|START_ENTITY beta|appos|END_ENTITY	Human sperm physiology : estrogen_receptor_alpha -LRB- ERa -RRB- and estrogen receptor beta -LRB- ERb -RRB- influence sperm metabolism and may be involved in the pathophysiology of varicocele-associated male_infertility .
21665249	0	estrogen	26,34	ERb	50,53	estrogen	ERb	MESH:D004967	2100	Chemical	Gene	beta|compound|START_ENTITY beta|appos|END_ENTITY	Cytoplasmic expression of estrogen receptor beta -LRB- ERb -RRB- predicts poor clinical outcome in advanced serous ovarian_cancer .
23060014	0	estrogen	44,52	ERb	68,71	estrogen	ERb	MESH:D004967	2100	Chemical	Gene	beta|compound|START_ENTITY beta|appos|END_ENTITY	Cyclin_D1 -LRB- CCND1 -RRB- expression is involved in estrogen receptor beta -LRB- ERb -RRB- in human prostate_cancer .
23860318	0	estrogen	9,17	ERb	131,134	estrogen	ERb	MESH:D004967	2100	Chemical	Gene	responsive|amod|START_ENTITY element|amod|responsive element|nsubj|element element|nmod|transactivation transactivation|compound|END_ENTITY	A distal estrogen responsive element upstream the cap site of human transthyretin gene is an enhancer-like element upon ERa and/or ERb transactivation .
24378878	0	estrogen	31,39	ERb	55,58	estrogen	ERb	MESH:D004967	2100	Chemical	Gene	beta|amod|START_ENTITY beta|appos|END_ENTITY	Prognostic significance of the estrogen receptor beta -LRB- ERb -RRB- isoforms ERb1 , ERb2 , and ERb5 in advanced serous ovarian_cancer .
26298498	0	estrogen	45,53	ERb	69,72	estrogen	ERb	MESH:D004967	2100	Chemical	Gene	receptor-beta|compound|START_ENTITY receptor-beta|appos|END_ENTITY	Design and synthesis of carborane-containing estrogen receptor-beta -LRB- ERb -RRB- - selective ligands .
10432221	0	estrogen	18,26	ERbeta	42,48	estrogen	ERbeta	MESH:D004967	281146(Tax:9913)	Chemical	Gene	beta|compound|START_ENTITY beta|appos|END_ENTITY	Cloning of bovine estrogen receptor beta -LRB- ERbeta -RRB- : expression of novel deleted isoforms in reproductive tissues .
10499508	0	estrogen	20,28	ERbeta	44,50	estrogen	ERbeta	MESH:D004967	25149(Tax:10116)	Chemical	Gene	receptor-beta|compound|START_ENTITY Characterization|nmod|receptor-beta Characterization|appos|END_ENTITY	Characterization of estrogen receptor-beta -LRB- ERbeta -RRB- messenger ribonucleic_acid and protein expression in rat granulosa cells .
10579320	0	estrogen	4,12	ERbeta	36,42	estrogen	ERbeta	MESH:D004967	2100	Chemical	Gene	beta-isoform|amod|START_ENTITY beta-isoform|appos|END_ENTITY	The estrogen receptor beta-isoform -LRB- ERbeta -RRB- of the human estrogen receptor modulates ERalpha transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens .
10579320	0	estrogen	57,65	ERbeta	36,42	estrogen	ERbeta	MESH:D004967	2100	Chemical	Gene	receptor|compound|START_ENTITY beta-isoform|nmod|receptor beta-isoform|appos|END_ENTITY	The estrogen receptor beta-isoform -LRB- ERbeta -RRB- of the human estrogen receptor modulates ERalpha transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens .
10762694	0	estrogen	16,24	ERbeta	40,46	estrogen	ERbeta	MESH:D004967	2100	Chemical	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Distribution of estrogen receptor beta -LRB- ERbeta -RRB- mRNA in hypothalamus , midbrain and temporal lobe of spayed macaque : continued expression with hormone replacement .
11726203	0	estrogen	27,35	ERbeta	51,57	estrogen	ERbeta	MESH:D004967	2100	Chemical	Gene	beta|compound|START_ENTITY beta|appos|END_ENTITY	Differential expression of estrogen receptor beta -LRB- ERbeta -RRB- and its C-terminal truncated splice variant ERbetacx as prognostic predictors in human prostatic_cancer .
11850023	0	estrogen	68,76	ERbeta	92,98	estrogen	ERbeta	MESH:D004967	25149(Tax:10116)	Chemical	Gene	receptor-beta|compound|START_ENTITY receptor-beta|appos|END_ENTITY	Age differentially influences estrogen receptor-alpha -LRB- ERalpha -RRB- and estrogen receptor-beta -LRB- ERbeta -RRB- gene expression in specific regions of the rat brain .
11959119	0	estrogen	127,135	ERbeta	35,41	estrogen	ERbeta	MESH:D004967	2100	Chemical	Gene	mRNA|amod|START_ENTITY pattern|nmod|mRNA mRNAs|dep|pattern mRNAs|compound|END_ENTITY	Identification of ten exon deleted ERbeta mRNAs in human ovary , breast , uterus and bone tissues : alternate splicing pattern of estrogen receptor beta mRNA is distinct from that of estrogen_receptor_alpha .
12477486	0	estrogen	36,44	ERbeta	65,71	estrogen	ERbeta	MESH:D004967	2100	Chemical	Gene	cDNA|amod|START_ENTITY isoform|nmod|cDNA Cloning|nmod|isoform Cloning|appos|cDNA cDNA|compound|END_ENTITY	Cloning of the novel isoform of the estrogen receptor beta cDNA -LRB- ERbeta isoform M cDNA -RRB- from the human testicular cDNA library .
12497580	0	estrogen	31,39	ERbeta	55,61	estrogen	ERbeta	MESH:D004967	2100	Chemical	Gene	beta|compound|START_ENTITY expression|nmod|beta expression|appos|END_ENTITY	Differential expression of the estrogen receptor beta -LRB- ERbeta -RRB- in human prostate tissue , premalignant changes , and in primary , metastatic , and recurrent prostatic_adenocarcinoma .
14568570	0	estrogen	25,33	ERbeta	49,55	estrogen	ERbeta	MESH:D004967	25149(Tax:10116)	Chemical	Gene	beta|compound|START_ENTITY beta|appos|END_ENTITY	Silymarin is a selective estrogen receptor beta -LRB- ERbeta -RRB- agonist and has estrogenic effects in the metaphysis_of_the_femur but no or antiestrogenic effects in the uterus of ovariectomized -LRB- ovx -RRB- rats .
15067372	3	estrogen	864,872	ERbeta	849,855	estrogen	ERbeta	MESH:D004967	2100	Chemical	Gene	treatment|compound|START_ENTITY dependent|nmod|treatment dependent|nmod|END_ENTITY	Western blot shows that the activation of JNK-signaling pathway , but not p38 and ERK , is dependent on ERbeta through estrogen treatment and APP-C105 is also mediated through estrogen in activating MAPK-signaling pathway .
15876415	3	estrogen	473,481	ERbeta	497,503	estrogen	ERbeta	MESH:D004967	2100	Chemical	Gene	beta|compound|START_ENTITY beta|appos|END_ENTITY	Red clover and soy extracts contain isoflavones , which have a high affinity to estrogen_receptor_alpha -LRB- ERalpha -RRB- , estrogen receptor beta -LRB- ERbeta -RRB- , progesterone_receptor -LRB- PR -RRB- and androgen_receptor -LRB- AR -RRB- .
15882902	0	estrogen	120,128	ERbeta	144,150	estrogen	ERbeta	MESH:D004967	25149(Tax:10116)	Chemical	Gene	receptor-beta|compound|START_ENTITY receptor-beta|appos|END_ENTITY	Estrogen stimulates galanin expression within luteinizing_hormone-releasing_hormone-immunoreactive -LRB- LHRH-i -RRB- neurons via estrogen receptor-beta -LRB- ERbeta -RRB- in the female rat brain .
16010412	0	estrogen	24,32	ERbeta	87,93	estrogen	ERbeta	MESH:D004967	2100	Chemical	Gene	START_ENTITY|xcomp|influence influence|dobj|complex complex|compound|END_ENTITY	Potential of endogenous estrogen receptor beta to influence the selective ER modulator ERbeta complex .
16675543	0	estrogen	86,94	ERbeta	151,157	estrogen	ERbeta	MESH:D004967	13983(Tax:10090)	Chemical	Gene	Y|nmod|START_ENTITY regulation|nmod|Y depends|nsubj|regulation depends|nmod|ratio ratio|nmod|_ _|amod|alpha alpha|nmod|END_ENTITY	Coordinate regulation of neuropeptide Y and agouti-related_peptide gene expression by estrogen depends on the ratio of estrogen_receptor _ -LRB- ER -RRB- _ alpha to ERbeta in clonal hypothalamic neurons .
17276717	0	estrogen	94,102	ERbeta	118,124	estrogen	ERbeta	MESH:D004967	2100	Chemical	Gene	beta|compound|START_ENTITY beta|appos|END_ENTITY	Effects of gonadotropin-releasing_hormone_analog _ -LRB- GnRHa -RRB- _ on_steroidogenic_factor-1 _ -LRB- SF-1 -RRB- and estrogen receptor beta -LRB- ERbeta -RRB- gene expression in the black porgy -LRB- Acanthopagrus schlegeli -RRB- .
17480015	0	estrogen	42,50	ERbeta	187,193	estrogen	ERbeta	MESH:D004967	25149(Tax:10116)	Chemical	Gene	receptor-beta|amod|START_ENTITY patterns|nmod|receptor-beta patterns|dep|localization localization|nmod|END_ENTITY	Distribution and localization patterns of estrogen receptor-beta and insulin-like_growth_factor-1 receptors in neurons and glial cells of the female rat substantia nigra : localization of ERbeta and IGF-1R in substantia nigra .
17854852	0	estrogen	131,139	ERbeta	149,155	estrogen	ERbeta	MESH:D004967	25149(Tax:10116)	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	5alpha-Androstane-3beta ,17 beta-diol -LRB- 3beta-diol -RRB- , an estrogenic metabolite of 5alpha-dihydrotestosterone , is a potent modulator of estrogen receptor ERbeta expression in the ventral prostrate of adult rats .
18406312	0	estrogen	16,24	ERbeta	0,6	estrogen	ERbeta	MESH:D004967	2100	Chemical	Gene	receptor|compound|START_ENTITY offers|nsubj|receptor END_ENTITY|parataxis|offers	ERbeta : a novel estrogen receptor offers the potential for new drug development .
18421469	0	estrogen	51,59	ERbeta	75,81	estrogen	ERbeta	MESH:D004967	2100	Chemical	Gene	beta|compound|START_ENTITY beta|appos|END_ENTITY	Human umbilical vascular endothelial cells express estrogen receptor beta -LRB- ERbeta -RRB- and progesterone_receptor A -LRB- PR-A -RRB- , but not ERalpha and PR-B .
20155458	0	estrogen	48,56	ERbeta	29,35	estrogen	ERbeta	MESH:D004967	2100	Chemical	Gene	signal|compound|START_ENTITY gene|nmod|signal gene|compound|END_ENTITY	Epigenetic regulation of the ERbeta gene on the estrogen signal transfection pathway in colon_cancer cells .
20494112	0	estrogen	12,20	ERbeta	36,42	estrogen	ERbeta	MESH:D004967	2100	Chemical	Gene	beta|compound|START_ENTITY beta|appos|END_ENTITY	The role of estrogen receptor beta -LRB- ERbeta -RRB- in malignant diseases -- a new potential target for antiproliferative drugs in prevention and treatment of cancer .
20646931	0	estrogen	32,40	ERbeta	0,6	estrogen	ERbeta	MESH:D004967	2100	Chemical	Gene	understanding|nmod|START_ENTITY END_ENTITY|dep|understanding	ERbeta : recent understanding of estrogen signaling .
9501254	0	estrogen	31,39	ERbeta	55,61	estrogen	ERbeta	MESH:D004967	25149(Tax:10116)	Chemical	Gene	beta|compound|START_ENTITY beta|appos|END_ENTITY	Differential colocalization of estrogen receptor beta -LRB- ERbeta -RRB- with oxytocin and vasopressin in the paraventricular and supraoptic nuclei of the female rat brain : an immunocytochemical study .
9892018	1	estrogen	116,124	ERbeta	190,196	estrogen	ERbeta	MESH:D004967	25149(Tax:10116)	Chemical	Gene	START_ENTITY|xcomp|signaling signaling|nmod|identification identification|nmod|receptor receptor|appos|END_ENTITY	A new level of complexity has recently been added to estrogen signaling with the identification of a second estrogen receptor , ERbeta .
9892018	1	estrogen	171,179	ERbeta	190,196	estrogen	ERbeta	MESH:D004967	25149(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	A new level of complexity has recently been added to estrogen signaling with the identification of a second estrogen receptor , ERbeta .
16919388	0	estrogen	21,29	ESR1	55,59	estrogen	ESR1	MESH:D004967	398734(Tax:8355)	Chemical	Gene	alpha|amod|START_ENTITY cloning|nmod|alpha cloning|appos|ERalpha ERalpha|dep|END_ENTITY	Molecular cloning of estrogen receptor alpha -LRB- ERalpha ; ESR1 -RRB- of the Japanese_giant_salamander , Andrias_japonicus .
17540666	0	estrogen	8,16	ESR1	29,33	estrogen	ESR1	MESH:D004967	2099	Chemical	Gene	variants|amod|START_ENTITY variants|amod|1 1|dep|END_ENTITY	Allelic estrogen receptor 1 -LRB- ESR1 -RRB- gene variants predict the outcome of ovarian stimulation in in_vitro_fertilization .
17904846	0	estrogen	43,51	ESR1	75,79	estrogen	ESR1	MESH:D004967	2099	Chemical	Gene	polymorphisms|nmod|START_ENTITY Association|nmod|polymorphisms receptors|nsubj|Association receptors|dobj|genes genes|amod|alpha alpha|dep|beta beta|appos|END_ENTITY	Association of repeat polymorphisms in the estrogen receptors alpha , beta -LRB- ESR1 , ESR2 -RRB- and androgen_receptor -LRB- AR -RRB- genes with the occurrence of breast_cancer .
18164902	0	estrogen	32,40	ESR1	59,63	estrogen	ESR1	MESH:D004967	2099	Chemical	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Analyses of variants located in estrogen metabolism genes -LRB- ESR1 , ESR2 , COMT and APOE -RRB- and schizophrenia .
18375409	0	estrogen	58,66	ESR1	25,29	estrogen	ESR1	MESH:D004967	2099	Chemical	Gene	activity|compound|START_ENTITY influence|dobj|activity polymorphisms|acl:relcl|influence polymorphisms|nmod|END_ENTITY	Genetic polymorphisms of ESR1 and ESR2 that may influence estrogen activity and the risk of hypospadias .
19439729	0	estrogen	9,17	ESR1	119,123	estrogen	ESR1	MESH:D004967	13982(Tax:10090)	Chemical	Gene	feedback|amod|START_ENTITY Impaired|dobj|feedback Impaired|nmod|deletion deletion|nmod|estrogen_receptor_alpha estrogen_receptor_alpha|appos|END_ENTITY	Impaired estrogen feedback and infertility in female mice with pituitary-specific deletion of estrogen_receptor_alpha -LRB- ESR1 -RRB- .
23036864	0	estrogen	8,16	ESR1	29,33	estrogen	ESR1	MESH:D004967	407238(Tax:9913)	Chemical	Gene	receptor-a|compound|START_ENTITY receptor-a|appos|END_ENTITY	Role of estrogen receptor-a -LRB- ESR1 -RRB- and the type 1 insulin-like growth factor receptor -LRB- IGFR1 -RRB- in estradiol-stimulated proliferation of cultured bovine satellite cells .
24647635	0	estrogen	32,40	ESR1	52,56	estrogen	ESR1	MESH:D004967	2099	Chemical	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Association of polymorphisms in estrogen receptors -LRB- ESR1 and ESR2 -RRB- with male_infertility : a meta-analysis and systematic review .
24815444	0	estrogen	61,69	ESR1	0,4	estrogen	ESR1	MESH:D004967	2099	Chemical	Gene	gene|nmod|START_ENTITY gene|nsubj|END_ENTITY	ESR1 and PGR gene promoter methylation and correlations with estrogen and progesterone_receptors in ductal_and_lobular_breast_cancer .
25428437	0	estrogen	20,28	ESR1	45,49	estrogen	ESR1	MESH:D004967	2099	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association between estrogen receptora gene -LRB- ESR1 -RRB- PvuII -LRB- T/C -RRB- and XbaI -LRB- A/G -RRB- polymorphisms and premature ovarian_failure risk : evidence from a meta-analysis .
26528103	0	estrogen	17,25	ESR1	51,55	estrogen	ESR1	MESH:D004967	2099	Chemical	Gene	Polymorphisms|nmod|START_ENTITY metabolism-related|nsubj|Polymorphisms metabolism-related|ccomp|associated associated|nsubjpass|genes genes|nummod|END_ENTITY	Polymorphisms of estrogen metabolism-related genes ESR1 , UGT2B17 , and UGT1A1 are not associated with osteoporosis in surgically menopausal Japanese women .
27004961	0	estrogen	22,30	ESR1	42,46	estrogen	ESR1	MESH:D004967	24890(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Differential roles of estrogen receptors , ESR1 and ESR2 , in adult rat spermatogenesis .
11185739	0	estrogen	15,23	ESR2	39,43	estrogen	ESR2	MESH:D004967	2100	Chemical	Gene	beta|compound|START_ENTITY beta|appos|END_ENTITY	Association of estrogen receptor beta -LRB- ESR2 -RRB- gene polymorphism with blood pressure .
16118344	0	estrogen	21,29	ESR2	45,49	estrogen	ESR2	MESH:D004967	2100	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Polymorphisms in the estrogen receptor beta -LRB- ESR2 -RRB- gene are associated with bone_mineral_density in Caucasian men and women .
17702854	0	estrogen	36,44	ESR2	65,69	estrogen	ESR2	MESH:D004967	2100	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms and haplotypes of the estrogen receptor-beta gene -LRB- ESR2 -RRB- and cardiovascular_disease in men and women .
17904846	0	estrogen	43,51	ESR2	81,85	estrogen	ESR2	MESH:D004967	2100	Chemical	Gene	polymorphisms|nmod|START_ENTITY Association|nmod|polymorphisms receptors|nsubj|Association receptors|dobj|genes genes|amod|alpha alpha|dep|beta beta|appos|ESR1 ESR1|dep|END_ENTITY	Association of repeat polymorphisms in the estrogen receptors alpha , beta -LRB- ESR1 , ESR2 -RRB- and androgen_receptor -LRB- AR -RRB- genes with the occurrence of breast_cancer .
18164902	0	estrogen	32,40	ESR2	65,69	estrogen	ESR2	MESH:D004967	2100	Chemical	Gene	genes|amod|START_ENTITY genes|appos|ESR1 ESR1|dep|END_ENTITY	Analyses of variants located in estrogen metabolism genes -LRB- ESR1 , ESR2 , COMT and APOE -RRB- and schizophrenia .
1986369	0	estrogen	33,41	Epidermal_growth_factor	0,23	estrogen	Epidermal growth factor	MESH:D004967	13645(Tax:10090)	Chemical	Gene	replaces|dobj|START_ENTITY replaces|nsubj|END_ENTITY	Epidermal_growth_factor replaces estrogen in the stimulation of female genital-tract growth and differentiation .
2364377	0	estrogen	95,103	Epidermal_growth_factor	0,23	estrogen	Epidermal growth factor	MESH:D004967	1950	Chemical	Gene	expression|compound|START_ENTITY relationship|nmod|expression expression|dep|relationship expression|amod|END_ENTITY	Epidermal_growth_factor gene expression in human breast_cancer biopsy samples : relationship to estrogen and progesterone_receptor gene expression .
11887937	0	estrogen	65,73	Epidermal_growth_factor_receptor	0,32	estrogen	Epidermal growth factor receptor	MESH:D004967	1956	Chemical	Gene	receptor|compound|START_ENTITY phosphorylation|nmod|receptor phosphorylation|compound|END_ENTITY	Epidermal_growth_factor_receptor and tyrosine phosphorylation of estrogen receptor .
11897506	0	estrogen	59,67	Epidermal_growth_factor_receptor	0,32	estrogen	Epidermal growth factor receptor	MESH:D004967	1956	Chemical	Gene	transactivation|nmod|START_ENTITY transactivation|amod|END_ENTITY	Epidermal_growth_factor_receptor -LRB- EGFR -RRB- transactivation by estrogen via the G-protein-coupled receptor , GPR30 : a novel signaling pathway with potential significance for breast_cancer .
19470835	0	estrogen	66,74	Epidermal_growth_factor_receptor	0,32	estrogen	Epidermal growth factor receptor	MESH:D004967	24329(Tax:10116)	Chemical	Gene	cross-talks|nmod|START_ENTITY cross-talks|amod|END_ENTITY	Epidermal_growth_factor_receptor cross-talks with ligand-occupied estrogen receptor-alpha to modulate both lactotroph proliferation and prolactin gene expression .
3401606	0	estrogen	75,83	Epidermal_growth_factor_receptor	0,32	estrogen	Epidermal growth factor receptor	MESH:D004967	1956	Chemical	Gene	receptors|compound|START_ENTITY correlation|nmod|receptors END_ENTITY|dep|correlation	Epidermal_growth_factor_receptor in human breast_cancers : correlation with estrogen and progesterone receptors .
22567014	3	estrogen	452,460	Era	568,571	estrogen	ERa	MESH:D004967	2099	Chemical	Gene	element|compound|START_ENTITY found|dobj|element found|nmod|dimers dimers|appos|END_ENTITY	Hypermethylation at the CpG islands found in estrogen response element -LRB- ERE -RRB- promoters occurs in conjunction with ligand-bonded alpha subunit estrogen receptor -LRB- Era -RRB- dimers wherein the ligand ERa dimer complex acts as a transcription factor and binds to the ERE promoter .
22567014	3	estrogen	549,557	Era	568,571	estrogen	ERa	MESH:D004967	2099	Chemical	Gene	dimers|compound|START_ENTITY dimers|appos|END_ENTITY	Hypermethylation at the CpG islands found in estrogen response element -LRB- ERE -RRB- promoters occurs in conjunction with ligand-bonded alpha subunit estrogen receptor -LRB- Era -RRB- dimers wherein the ligand ERa dimer complex acts as a transcription factor and binds to the ERE promoter .
10537315	0	estrogen	47,55	ErbB-4	37,43	estrogen	ErbB-4	MESH:D004967	2066	Chemical	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	Ribozyme-mediated down-regulation of ErbB-4 in estrogen receptor-positive breast_cancer cells inhibits proliferation both in vitro and in vivo .
11986328	0	estrogen	55,63	Estrogen-related_receptor_alpha	0,31	estrogen	Estrogen-related receptor alpha	MESH:D004967	2101	Chemical	Gene	transcription|amod|START_ENTITY antagonizes|dobj|transcription antagonizes|nsubj|END_ENTITY	Estrogen-related_receptor_alpha 1 actively antagonizes estrogen receptor-regulated transcription in MCF-7 mammary cells .
11162931	0	estrogen	46,54	Estrogen_receptor	0,17	estrogen	Estrogen receptor	MESH:D004967	2099	Chemical	Gene	responsiveness|compound|START_ENTITY role|nmod|responsiveness beta|dep|role beta|amod|END_ENTITY	Estrogen_receptor beta in the breast : role in estrogen responsiveness and development of breast_cancer .
11250729	0	estrogen	70,78	Estrogen_receptor	0,17	estrogen	Estrogen receptor	MESH:D004967	2099	Chemical	Gene	action|compound|START_ENTITY aspects|nmod|action transcription|dep|aspects transcription|compound|END_ENTITY	Estrogen_receptor transcription and transactivation : Basic aspects of estrogen action .
11452016	0	estrogen	35,43	Estrogen_receptor	0,17	estrogen	Estrogen receptor	MESH:D004967	2099	Chemical	Gene	elements|amod|START_ENTITY interaction|nmod|elements interaction|nsubj|END_ENTITY	Estrogen_receptor interaction with estrogen response elements .
15184047	0	estrogen	108,116	Estrogen_receptor	0,17	estrogen	Estrogen receptor	MESH:D004967	2099	Chemical	Gene	stimulates|compound|START_ENTITY expression|dep|stimulates expression|amod|END_ENTITY	Estrogen_receptor expression in a human primitive neuroectodermal_tumor cell line from the cerebral cortex : estrogen stimulates rapid ERK1/2 activation and receptor-dependent cell migration .
16971528	0	estrogen	228,236	Estrogen_receptor	0,17	estrogen	Estrogen receptor	MESH:D004967	2099	Chemical	Gene	action|compound|START_ENTITY mechanism|nmod|action 2|dep|mechanism interaction|dep|2 interaction|amod|END_ENTITY	Estrogen_receptor protein interaction with phosphatidylinositol 3-kinase leads to activation of phosphorylated Akt and extracellular_signal-regulated_kinase_1 / 2 in the same population of cortical neurons : a unified mechanism of estrogen action .
26383254	0	estrogen	48,56	Estrogen_receptor	0,17	estrogen	Estrogen receptor	MESH:D004967	2099	Chemical	Gene	neuroprotection|compound|START_ENTITY involved|nmod|neuroprotection involved|nsubjpass|ER-a36 ER-a36|amod|END_ENTITY	Estrogen_receptor variant ER-a36 is involved in estrogen neuroprotection against oxidative toxicity .
728201	0	estrogen	108,116	Estrogen_receptor	0,17	estrogen	Estrogen receptor	MESH:D004967	2099	Chemical	Gene	amount|nmod|START_ENTITY metabolism|nmod|amount effect|nmod|metabolism END_ENTITY|dep|effect	Estrogen_receptor in the mammalian liver : effect of metabolism on the amount and identity of receptor-bound estrogen .
7659089	0	estrogen	87,95	Estrogen_receptor	0,17	estrogen	Estrogen receptor	MESH:D004967	2099	Chemical	Gene	element|amod|START_ENTITY bind|nmod|element mutants|ccomp|bind mutants|nsubj|END_ENTITY	Estrogen_receptor mutants which do not bind 17_beta-estradiol dimerize and bind to the estrogen response element in vivo .
9247160	0	estrogen	88,96	Estrogen_receptor	0,17	estrogen	Estrogen receptor	MESH:D004967	100136026(Tax:8022)	Chemical	Gene	mobilization|nmod|START_ENTITY mRNA|dep|mobilization mRNA|compound|END_ENTITY	Estrogen_receptor mRNA in mineralized tissues of rainbow_trout : calcium mobilization by estrogen .
9607732	0	estrogen	67,75	Estrogen_receptor	0,17	estrogen	Estrogen receptor	MESH:D004967	2099	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|down-regulation down-regulation|compound|END_ENTITY	Estrogen_receptor down-regulation is regulated noncooperatively by estrogen at the transcription level .
12039798	0	estrogen	59,67	Estrogen_receptor-alpha	0,23	estrogen	Estrogen receptor-alpha	MESH:D004967	13982(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY mediates|dobj|effects mediates|nsubj|END_ENTITY	Estrogen_receptor-alpha mediates the protective effects of estrogen against vascular_injury .
12125913	0	estrogen	71,79	Estrogen_receptor-alpha	0,23	estrogen	Estrogen receptor-alpha	MESH:D004967	2099	Chemical	Gene	proteins|compound|START_ENTITY relationship|nmod|proteins mRNA|dep|relationship mRNA|amod|END_ENTITY	Estrogen_receptor-alpha mRNA in primary breast_cancer : relationship to estrogen and progesterone_receptor proteins and other prognostic factors .
12399412	0	estrogen	61,69	Estrogen_receptor-alpha	0,23	estrogen	Estrogen receptor-alpha	MESH:D004967	13982(Tax:10090)	Chemical	Gene	stimulation|compound|START_ENTITY modulates|dobj|stimulation modulates|nsubj|END_ENTITY	Estrogen_receptor-alpha -LRB- ERalpha -RRB- , but not ERbeta , modulates estrogen stimulation of the ERalpha-truncated variant , TERP-1 .
12697707	0	estrogen	38,46	Estrogen_receptor-alpha	0,23	estrogen	Estrogen receptor-alpha	MESH:D004967	13982(Tax:10090)	Chemical	Gene	dependency|nmod|START_ENTITY dependency|amod|END_ENTITY	Estrogen_receptor-alpha dependency of estrogen 's stimulatory action on cancellous bone formation in male mice .
15550515	0	estrogen	33,41	Estrogen_receptor-alpha	0,23	estrogen	Estrogen receptor-alpha	MESH:D004967	13982(Tax:10090)	Chemical	Gene	facilitation|compound|START_ENTITY mediates|dobj|facilitation mediates|nsubj|END_ENTITY	Estrogen_receptor-alpha mediates estrogen facilitation of baroreflex heart rate responses in conscious mice .
16322326	0	estrogen	112,120	Estrogen_receptor-alpha	0,23	estrogen	Estrogen receptor-alpha	MESH:D004967	2099	Chemical	Gene	exposed|nmod|START_ENTITY exposed|nsubj|changes changes|amod|END_ENTITY	Estrogen_receptor-alpha mediates gene expression changes and growth response in ovarian_cancer cells exposed to estrogen .
17142339	0	estrogen	33,41	Estrogen_receptor-alpha	0,23	estrogen	Estrogen receptor-alpha	MESH:D004967	13982(Tax:10090)	Chemical	Gene	protection|compound|START_ENTITY mediates|dobj|protection mediates|nsubj|END_ENTITY	Estrogen_receptor-alpha mediates estrogen protection from angiotensin_II-induced hypertension in conscious female mice .
10736185	0	estrogen	41,49	Estrogen_receptor_alpha	0,23	estrogen	Estrogen receptor alpha	MESH:D004967	13982(Tax:10090)	Chemical	Gene	half-sites|amod|START_ENTITY interaction|nmod|half-sites interaction|nsubj|END_ENTITY	Estrogen_receptor_alpha interaction with estrogen response element half-sites from the rat prolactin gene .
11886765	0	estrogen	114,122	Estrogen_receptor_alpha	0,23	estrogen	Estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	polymorphism|nmod|START_ENTITY polymorphism|nsubj|END_ENTITY	Estrogen_receptor_alpha polymorphism as a genetic marker for bone_loss , vertebral_fractures and susceptibility to estrogen .
14662901	0	estrogen	33,41	Estrogen_receptor_alpha	0,23	estrogen	Estrogen receptor alpha	MESH:D004967	13982(Tax:10090)	Chemical	Gene	protection|nmod:poss|START_ENTITY mediates|dobj|protection mediates|nsubj|END_ENTITY	Estrogen_receptor_alpha mediates estrogen 's immune protection in autoimmune_disease .
15665095	0	estrogen	81,89	Estrogen_receptor_alpha	0,23	estrogen	Estrogen receptor alpha	MESH:D004967	13982(Tax:10090)	Chemical	Gene	ventral|nmod|START_ENTITY ventral|nsubj|END_ENTITY	Estrogen_receptor_alpha and imprinting of the neonatal mouse ventral prostate by estrogen .
15802376	0	estrogen	70,78	Estrogen_receptor_alpha	0,23	estrogen	Estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	expression|amod|START_ENTITY exert|nmod|expression exert|nsubj|END_ENTITY	Estrogen_receptor_alpha and beta heterodimers exert unique effects on estrogen - and tamoxifen-dependent gene expression in human U2OS osteosarcoma cells .
16139450	0	estrogen	124,132	Estrogen_receptor_alpha	0,23	estrogen	Estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|polymorphisms polymorphisms|compound|END_ENTITY	Estrogen_receptor_alpha gene polymorphisms are associated with changes in bone remodeling markers and treatment response to estrogen .
16396937	0	estrogen	56,64	Estrogen_receptor_alpha	0,23	estrogen	Estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	action|compound|START_ENTITY polymorphism|dep|action polymorphism|compound|END_ENTITY	Estrogen_receptor_alpha promoter polymorphism : stronger estrogen action is coupled with lower sperm count .
16782420	0	estrogen	84,92	Estrogen_receptor_alpha	0,23	estrogen	Estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	confers|nmod|START_ENTITY confers|nsubj|genotype genotype|compound|END_ENTITY	Estrogen_receptor_alpha genotype confers interindividual variability of response to estrogen and testosterone in mesenchymal-stem-cell-derived osteoblasts .
18166184	0	estrogen	74,82	Estrogen_receptor_alpha	0,23	estrogen	Estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	responsiveness|compound|START_ENTITY basis|nmod|responsiveness END_ENTITY|dep|basis	Estrogen_receptor_alpha and beta in uterine fibroids : a basis for altered estrogen responsiveness .
18243688	0	estrogen	57,65	Estrogen_receptor_alpha	0,23	estrogen	Estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	beta|compound|START_ENTITY patients|dep|beta patients|amod|END_ENTITY	Estrogen_receptor_alpha negative breast_cancer patients : estrogen receptor beta as a therapeutic target .
19299445	0	estrogen	66,74	Estrogen_receptor_alpha	0,23	estrogen	Estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	effects|nmod|START_ENTITY mediates|dobj|effects mediates|nsubj|END_ENTITY	Estrogen_receptor_alpha -LRB- ERalpha -RRB- mediates stimulatory effects of estrogen on aromatase -LRB- CYP19 -RRB- gene expression in human placenta .
19886840	0	estrogen	120,128	Estrogen_receptor_alpha	0,23	estrogen	Estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	neuroprotection|compound|START_ENTITY implications|nmod|neuroprotection suppression|dep|implications inhibits|dobj|suppression inhibits|nsubj|END_ENTITY	Estrogen_receptor_alpha inhibits the estrogen-mediated suppression of HIV transcription in astrocytes : implications for estrogen neuroprotection in HIV_dementia .
9579693	0	estrogen	75,83	Estrogen_receptor_alpha	0,23	estrogen	Estrogen receptor alpha	MESH:D004967	13982(Tax:10090)	Chemical	Gene	essential|nmod|START_ENTITY essential|nsubj|END_ENTITY	Estrogen_receptor_alpha is essential for induction of oxytocin_receptor by estrogen .
9927501	0	estrogen	99,107	Estrogen_receptor_alpha	0,23	estrogen	Estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Estrogen_receptor_alpha mediates the nongenomic activation of endothelial nitric_oxide synthase by estrogen .
9056169	0	estrogen	180,188	FLG	192,195	estrogen	FLG	MESH:D004967	2312	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	A human homolog of the 150 kD avian osteoclast membrane antigen related to superoxide dismutase and essential for bone resorption is induced by developmental agents and opposed by estrogen in FLG 29.1 cells .
25369636	0	estrogen	41,49	FOXL2	25,30	estrogen	FOXL2	MESH:D004967	26927(Tax:10090)	Chemical	Gene	mobilizes|dobj|START_ENTITY mobilizes|nsubj|END_ENTITY	The transcription factor FOXL2 mobilizes estrogen signaling to maintain the identity of ovarian granulosa cells .
12113885	0	estrogen	39,47	Fas_ligand	14,24	estrogen	Fas ligand	MESH:D004967	356	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of Fas_ligand expression by estrogen in normal ovary .
12496390	0	estrogen	19,27	Fas_ligand	47,57	estrogen	Fas ligand	MESH:D004967	356	Chemical	Gene	Interaction|nmod|START_ENTITY receptors|nsubj|Interaction receptors|nmod|promoter promoter|compound|END_ENTITY	Interaction of the estrogen receptors with the Fas_ligand promoter in human monocytes .
24853420	0	estrogen	71,79	FoxA1	130,135	estrogen	FoxA1	MESH:D004967	3169	Chemical	Gene	START_ENTITY|advcl|regulating regulating|dobj|expression expression|amod|END_ENTITY	Tip30 controls differentiation of murine mammary luminal progenitor to estrogen receptor-positive luminal cell through regulating FoxA1 expression .
21354433	0	estrogen	42,50	G-protein-coupled-receptor-30	61,90	estrogen	G-protein-coupled-receptor-30	MESH:D004967	2852	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Retrograde transport of the transmembrane estrogen receptor , G-protein-coupled-receptor-30 -LRB- GPR30/GPER -RRB- from the plasma membrane towards the nucleus .
18434348	0	estrogen	10,18	G-protein-coupled_receptor	28,54	estrogen	G-protein-coupled receptor	MESH:D004967	2852	Chemical	Gene	receptor|compound|START_ENTITY receptor|dep|END_ENTITY	The novel estrogen receptor G-protein-coupled_receptor 30 is expressed in human bone .
22492045	0	estrogen	72,80	G-protein-coupled_receptor_30	0,29	estrogen	G-protein-coupled receptor 30	MESH:D004967	76854(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY mediates|dobj|effects mediates|nsubj|END_ENTITY	G-protein-coupled_receptor_30 mediates rapid neuroprotective effects of estrogen via depression of NR2B-containing NMDA receptors .
10566634	0	estrogen	9,17	GH	68,70	estrogen	GH	MESH:D004967	2688	Chemical	Gene	administration|compound|START_ENTITY Route|nmod|administration helps|nsubj|Route helps|xcomp|determine determine|dobj|dose dose|amod|growth_hormone growth_hormone|dep|END_ENTITY	Route of estrogen administration helps to determine growth_hormone -LRB- GH -RRB- replacement dose in GH-deficient adults .
14715838	0	estrogen	181,189	GH	98,100	estrogen	GH	MESH:D004967	2688	Chemical	Gene	facilitates|compound|START_ENTITY endogenous|nsubj|facilitates evidence|dep|endogenous release|dep|evidence release|nmod|growth_hormone growth_hormone|appos|END_ENTITY	Estradiol supplementation in postmenopausal women doubles rebound-like release of growth_hormone -LRB- GH -RRB- triggered by sequential infusion and withdrawal of somatostatin : evidence that estrogen facilitates endogenous GH-releasing hormone drive .
16246898	0	estrogen	13,21	GH	79,81	estrogen	GH	MESH:D004967	14599(Tax:10090)	Chemical	Gene	administration|compound|START_ENTITY Influence|nmod|administration Influence|appos|END_ENTITY	Influence of estrogen administration on the growth response to growth_hormone -LRB- GH -RRB- in GH-deficient mice .
17686882	0	estrogen	11,19	GH	73,75	estrogen	GH	MESH:D004967	2688	Chemical	Gene	receptor-alpha|compound|START_ENTITY modulates|nsubj|receptor-alpha modulates|dobj|waveform waveform|nmod|bursts bursts|compound|END_ENTITY	Peripheral estrogen receptor-alpha selectively modulates the waveform of GH secretory bursts in healthy women .
1991807	0	estrogen	54,62	GH	110,112	estrogen	GH	MESH:D004967	2688	Chemical	Gene	therapy|compound|START_ENTITY therapy|nmod|growth_hormone growth_hormone|appos|END_ENTITY	Contrasting effects of oral and transdermal routes of estrogen replacement therapy on 24-hour growth_hormone -LRB- GH -RRB- secretion , insulin-like_growth_factor_I , and GH-binding protein in postmenopausal women .
3100282	0	estrogen	10,18	GH	42,44	estrogen	GH	MESH:D004967	81668(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|response response|appos|END_ENTITY	Effect of estrogen on the growth_hormone -LRB- GH -RRB- secretory response to GH-releasing factor in the castrate adult female rat in vivo .
3946321	1	estrogen	122,130	GH	167,169	estrogen	GH	MESH:D004967	2688	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|appos|END_ENTITY	We tested the concept that estrogen directly stimulates growth_hormone -LRB- GH -RRB- production by determining whether low-dose treatment with ethinyl_estradiol increases the GH reserve , as assessed by levodopa administration , without inhibiting somatomedin-C -LRB- Sm-C -RRB- levels .
15896872	0	estrogen	80,88	GLAST	36,41	estrogen	GLAST	MESH:D004967	20512(Tax:10090)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of glutamate transporter GLAST and GLT-1 expression in astrocytes by estrogen .
19228597	0	estrogen	29,37	GPER	87,91	estrogen	GPER	MESH:D004967	2852	Chemical	Gene	receptor|compound|START_ENTITY Identification|nmod|receptor Identification|nmod|homology homology|nmod|END_ENTITY	Identification of a membrane estrogen receptor in zebrafish with homology to mammalian GPER and its high expression in early germ cells of the testis .
19717735	0	estrogen	22,30	GPER	41,45	estrogen	GPER	MESH:D004967	171104(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Activation of a novel estrogen receptor , GPER , is cardioprotective in male and female rats .
19931550	0	estrogen	10,18	GPER	97,101	estrogen	GPER	MESH:D004967	2852	Chemical	Gene	START_ENTITY|dobj|functions functions|nmod|G_protein-coupled_estrogen_receptor_1 G_protein-coupled_estrogen_receptor_1|appos|END_ENTITY	Conserved estrogen binding and signaling functions of the G_protein-coupled_estrogen_receptor_1 -LRB- GPER -RRB- in mammals and fish .
21540189	0	estrogen	41,49	GPER	60,64	estrogen	GPER	MESH:D004967	2852	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Down-modulation of the G-protein-coupled estrogen receptor , GPER , from the cell surface occurs via a trans-Golgi-proteasome pathway .
22378861	0	estrogen	18,26	GPER	37,41	estrogen	GPER	MESH:D004967	2852	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	G protein-coupled estrogen receptor -LRB- GPER -RRB- expression in normal and abnormal endometrium .
23420106	0	estrogen	24,32	GPER	43,47	estrogen	GPER	MESH:D004967	76854(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Expression of G protein estrogen receptor -LRB- GPER -RRB- on membrane of mouse oocytes during maturation .
23466742	0	estrogen	37,45	GPER	0,4	estrogen	GPER	MESH:D004967	2852	Chemical	Gene	action|compound|START_ENTITY target|nmod|action END_ENTITY|dep|target	GPER : a novel target for non-genomic estrogen action in the cardiovascular system .
23602294	0	estrogen	125,133	GPER	89,93	estrogen	GPER	MESH:D004967	2852	Chemical	Gene	women|amod|START_ENTITY reducing|nmod|women reducing|dobj|catabolism catabolism|nmod|pathway pathway|compound|END_ENTITY	Calcium supplementation increases circulating cholesterol by reducing its catabolism via GPER and TRPC1-dependent pathway in estrogen deficient women .
23871778	0	estrogen	40,48	GPER	0,4	estrogen	GPER	MESH:D004967	76854(Tax:10090)	Chemical	Gene	actions|nmod|START_ENTITY mediates|dobj|actions mediates|nsubj|END_ENTITY	GPER mediates the inhibitory actions of estrogen on adipogenesis in 3T3-L1 cells through perturbation of mitotic clonal expansion .
24446390	0	estrogen	8,16	GPER	93,97	estrogen	GPER	MESH:D004967	2852	Chemical	Gene	GPER|compound|START_ENTITY mediates|nsubj|GPER mediates|dobj|proliferation proliferation|acl|induced induced|nmod|G-1 G-1|amod|END_ENTITY	A novel estrogen receptor GPER mediates proliferation induced by 17b-estradiol and selective GPER agonist G-1 in estrogen_receptor_a -LRB- ERa -RRB- - negative ovarian_cancer cells .
24560890	0	estrogen	45,53	GPER	64,68	estrogen	GPER	MESH:D004967	76854(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Sexually dimorphic role of G protein-coupled estrogen receptor -LRB- GPER -RRB- in modulating energy homeostasis .
24607572	0	estrogen	68,76	GPER	151,155	estrogen	GPER	MESH:D004967	100053626(Tax:9796)	Chemical	Gene	ESR1|amod|START_ENTITY ESR1|nmod|END_ENTITY	Stallion spermatozoa : putative target of estrogens ; presence of the estrogen receptors ESR1 , ESR2 and identification of the estrogen-membrane receptor GPER .
25485460	0	estrogen	18,26	GPER	37,41	estrogen	GPER	MESH:D004967	565271(Tax:7955)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	G-protein coupled estrogen receptor -LRB- GPER -RRB- inhibits final oocyte maturation in common_carp , Cyprinus_carpio .
25936661	0	estrogen	20,28	GPER	38,42	estrogen	GPER	MESH:D004967	2852	Chemical	Gene	results|compound|START_ENTITY results|compound|END_ENTITY	Activation of novel estrogen receptor GPER results in inhibition of cardiocyte apoptosis and cardioprotection .
26190834	0	estrogen	22,30	GPER	41,45	estrogen	GPER	MESH:D004967	2852	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	The G-protein coupled estrogen receptor , GPER : The inside and inside-out story .
26190834	0	estrogen	22,30	GPER	41,45	estrogen	GPER	MESH:D004967	2852	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	The G-protein coupled estrogen receptor , GPER : The inside and inside-out story .
26281354	0	estrogen	35,43	GPER	1,5	estrogen	GPER	MESH:D004967	2852	Chemical	Gene	player|nmod|START_ENTITY receptor|dep|player receptor|compound|END_ENTITY	-LSB- GPER receptor - the new player in estrogen signaling -RSB- .
26281354	0	estrogen	35,43	GPER	1,5	estrogen	GPER	MESH:D004967	2852	Chemical	Gene	player|nmod|START_ENTITY receptor|dep|player receptor|compound|END_ENTITY	-LSB- GPER receptor - the new player in estrogen signaling -RSB- .
23907016	10	estrogen	1882,1890	GPER1	1905,1910	estrogen	CXCR1	MESH:D004967	3577	Chemical	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	In conclusion , we demonstrated that estrogen signaling via GPER1 associated with the metastasis of breast_cancer , which might be through GPER1/ERK _ AKT/NF-kB/IL -8 / CXCR1 cascade .
11897506	0	estrogen	59,67	GPR30	104,109	estrogen	GPR30	MESH:D004967	2852	Chemical	Gene	START_ENTITY|nmod|receptor receptor|appos|END_ENTITY	Epidermal_growth_factor_receptor -LRB- EGFR -RRB- transactivation by estrogen via the G-protein-coupled receptor , GPR30 : a novel signaling pathway with potential significance for breast_cancer .
16125968	0	estrogen	38,46	GPR30	0,5	estrogen	GPR30	MESH:D004967	2852	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|dep|receptor	GPR30 : a seven-transmembrane-spanning estrogen receptor that triggers EGF release .
17222505	0	estrogen	40,48	GPR30	0,5	estrogen	GPR30	MESH:D004967	2852	Chemical	Gene	receptor|nmod|START_ENTITY END_ENTITY|dep|receptor	GPR30 : A G protein-coupled receptor for estrogen .
17379646	0	estrogen	24,32	GPR30	73,78	estrogen	GPR30	MESH:D004967	2852	Chemical	Gene	G_protein-coupled_receptor_30|compound|START_ENTITY Activation|nmod|G_protein-coupled_receptor_30 Activation|appos|END_ENTITY	Activation of the novel estrogen receptor G_protein-coupled_receptor_30 -LRB- GPR30 -RRB- at the plasma membrane .
17655271	0	estrogen	10,18	GPR30	78,83	estrogen	GPR30	MESH:D004967	2852	Chemical	Gene	derivatives|compound|START_ENTITY demonstrate|nsubj|derivatives demonstrate|dobj|functionality functionality|nmod|END_ENTITY	Synthetic estrogen derivatives demonstrate the functionality of intracellular GPR30 .
17878253	0	estrogen	6,14	GPR30	0,5	estrogen	GPR30	MESH:D004967	2852	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	GPR30 estrogen receptor expression in the growth plate declines as puberty progresses .
18289622	0	estrogen	28,36	GPR30	47,52	estrogen	GPR30	MESH:D004967	2852	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Association of the membrane estrogen receptor , GPR30 , with breast_tumor metastasis and transactivation of the epidermal_growth_factor_receptor .
18371086	0	estrogen	6,14	GPR30	0,5	estrogen	GPR30	MESH:D004967	171104(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|nummod|END_ENTITY	GPR30 estrogen receptor agonists induce mechanical_hyperalgesia in the rat .
18406603	0	estrogen	43,51	GPR30	20,25	estrogen	GPR30	MESH:D004967	2852	Chemical	Gene	receptor|compound|START_ENTITY ins|dep|receptor ins|nmod|END_ENTITY	The ins and outs of GPR30 : a transmembrane estrogen receptor .
19088255	0	estrogen	67,75	GPR30	43,48	estrogen	GPR30	MESH:D004967	76854(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nmod|effects	The role of the G protein-coupled receptor GPR30 in the effects of estrogen in ovariectomized mice .
19125412	0	estrogen	14,22	GPR30	32,37	estrogen	GPR30	MESH:D004967	171104(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY Expression|nmod|receptor END_ENTITY|nsubj|Expression	Expression of estrogen receptor GPR30 in the rat spinal cord and in autonomic and sensory ganglia .
19131510	0	estrogen	72,80	GPR30	46,51	estrogen	GPR30	MESH:D004967	2852	Chemical	Gene	action|nmod|START_ENTITY G_protein-coupled_receptor_30|nmod|action G_protein-coupled_receptor_30|appos|END_ENTITY	Involvement of G_protein-coupled_receptor_30 -LRB- GPR30 -RRB- in rapid action of estrogen in primate LHRH neurons .
19464786	0	estrogen	14,22	GPR30	57,62	estrogen	GPR30	MESH:D004967	2852	Chemical	Gene	signaling|amod|START_ENTITY Mechanisms|nmod|signaling Mechanisms|nmod|END_ENTITY	Mechanisms of estrogen signaling and gene expression via GPR30 .
19549922	0	estrogen	22,30	GPR30	16,21	estrogen	GPR30	MESH:D004967	2852	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Stimulating the GPR30 estrogen receptor with a novel tamoxifen analogue activates SF-1 and promotes endometrial cell proliferation .
20086172	0	estrogen	63,71	GPR30	31,36	estrogen	GPR30	MESH:D004967	2852	Chemical	Gene	cells|amod|START_ENTITY proliferation|nmod|cells inhibits|dobj|proliferation inhibits|nsubj|END_ENTITY	The G protein-coupled receptor GPR30 inhibits proliferation of estrogen receptor-positive breast_cancer cells .
20197310	0	estrogen	78,86	GPR30	57,62	estrogen	GPR30	MESH:D004967	2852	Chemical	Gene	signaling|compound|START_ENTITY Involvement|nmod|signaling Involvement|amod|END_ENTITY	Involvement of estrogen_receptor variant ER-alpha36 , not GPR30 , in nongenomic estrogen signaling .
21138734	0	estrogen	31,39	GPR30	0,5	estrogen	GPR30	MESH:D004967	2852	Chemical	Gene	effects|compound|START_ENTITY mediate|dobj|effects positioned|xcomp|mediate positioned|nsubjpass|END_ENTITY	GPR30 is positioned to mediate estrogen effects on basal forebrain cholinergic neurons and cognitive performance .
21170498	0	estrogen	27,35	GPR30	46,51	estrogen	GPR30	MESH:D004967	2852	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	-LSB- The expression of a novel estrogen receptor , GPR30 , in epithelial_ovarian_carcinoma and its correlation with MMP-9 -RSB- .
22153880	0	estrogen	105,113	GPR30	54,59	estrogen	GPR30	MESH:D004967	2852	Chemical	Gene	actions|nmod|START_ENTITY contributes|nmod|actions contributes|nsubj|END_ENTITY	Evidence that the G protein-coupled membrane receptor GPR30 contributes to the cardiovascular actions of estrogen .
22496838	0	estrogen	52,60	GPR30	0,5	estrogen	GPR30	MESH:D004967	2852	Chemical	Gene	receptor|compound|START_ENTITY protein|dep|receptor END_ENTITY|appos|protein	GPR30 , the non-classical membrane G protein related estrogen receptor , is overexpressed in human seminoma and promotes seminoma cell proliferation .
23235274	0	estrogen	79,87	GPR30	31,36	estrogen	GPR30	MESH:D004967	2852	Chemical	Gene	effect|nmod|START_ENTITY mediates|dobj|effect mediates|nsubj|END_ENTITY	The G protein-coupled receptor GPR30 mediates the nontranscriptional effect of estrogen on the activation of PI3K/Akt pathway in endometrial_cancer cells .
23300088	0	estrogen	96,104	GPR30	85,90	estrogen	GPR30	MESH:D004967	171104(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY capacity|appos|receptor capacity|nmod|receptor receptor|appos|END_ENTITY	Post-synaptic_density-95 -LRB- PSD-95 -RRB- binding capacity of G-protein-coupled receptor 30 -LRB- GPR30 -RRB- , an estrogen receptor that can be identified in hippocampal dendritic spines .
24011568	0	estrogen	15,23	GPR30	34,39	estrogen	GPR30	MESH:D004967	2852	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Biology of the estrogen receptor , GPR30 , in triple negative breast_cancer .
24440569	0	estrogen	151,159	GPR30	170,175	estrogen	GPR30	MESH:D004967	2852	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Estrogen and pure antiestrogen fulvestrant -LRB- ICI_182_780 -RRB- augment cell-matrigel adhesion of MCF-7 breast_cancer cells through a novel G protein coupled estrogen receptor -LRB- GPR30 -RRB- - to-calpain signaling axis .
24594140	0	estrogen	15,23	GPR30	0,5	estrogen	GPR30	MESH:D004967	171104(Tax:10116)	Chemical	Gene	signaling|amod|START_ENTITY mediates|dobj|signaling mediates|nsubj|END_ENTITY	GPR30 mediates estrogen rapid signaling and neuroprotection .
24835924	0	estrogen	27,35	GPR30	12,17	estrogen	GPR30	MESH:D004967	171104(Tax:10116)	Chemical	Gene	START_ENTITY|nmod:npmod|mediates mediates|nummod|END_ENTITY	Reprint of `` GPR30 mediates estrogen rapid signaling and neuroprotection '' .
25275589	0	estrogen	82,90	GPR30	49,54	estrogen	GPR30	MESH:D004967	2852	Chemical	Gene	cells|amod|START_ENTITY proliferation|nmod|cells inhibits|dobj|proliferation inhibits|nsubj|activation activation|nmod|G_protein-coupled_receptor_30 G_protein-coupled_receptor_30|appos|END_ENTITY	The activation of G_protein-coupled_receptor_30 -LRB- GPR30 -RRB- inhibits proliferation of estrogen receptor-negative breast_cancer cells in vitro and in vivo .
25280432	0	estrogen	19,27	GPR30	37,42	estrogen	GPR30	MESH:D004967	171104(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY Role|nmod|receptor END_ENTITY|nsubj|Role	Role of nociceptor estrogen receptor GPR30 in a rat model of endometriosis_pain .
25413376	0	estrogen	110,118	GPR30	15,20	estrogen	GPR30	MESH:D004967	2852	Chemical	Gene	receptor-beta|compound|START_ENTITY levels|nmod|receptor-beta correlate|nmod|levels correlate|nsubj|levels levels|nmod|protein protein|nummod|END_ENTITY	High levels of GPR30 protein in human testicular_carcinoma in situ_and_seminomas correlate with low levels of estrogen receptor-beta and indicate a switch in estrogen responsiveness .
26187146	0	estrogen	27,35	GPR30	54,59	estrogen	GPR30	MESH:D004967	171104(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY membrane|nsubj|effects membrane|dobj|END_ENTITY	Osteoprotective effects of estrogen membrane receptor GPR30 in ovariectomized rats .
26815911	0	estrogen	35,43	GPR30	53,58	estrogen	GPR30	MESH:D004967	2852	Chemical	Gene	receptor|compound|START_ENTITY roles|nmod|receptor END_ENTITY|nsubj|roles	Expression and functional roles of estrogen receptor GPR30 in human intervertebral_disc .
22543280	0	estrogen	17,25	GRP78	0,5	estrogen	GRP78	MESH:D004967	3309	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	GRP78 induced by estrogen plays a role in the chemosensitivity of endometrial_cancer .
17872373	0	estrogen	74,82	G_protein-coupled_receptor-30	14,43	estrogen	G protein-coupled receptor-30	MESH:D004967	171104(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|appos|receptor	Expression of G_protein-coupled_receptor-30 , a G protein-coupled membrane estrogen receptor , in oxytocin neurons of the rat paraventricular and supraoptic nuclei .
18499747	0	estrogen	57,65	G_protein-coupled_receptor_30	0,29	estrogen	G protein-coupled receptor 30	MESH:D004967	2852	Chemical	Gene	stimulation|compound|START_ENTITY required|nmod|stimulation required|nsubjpass|expression expression|amod|END_ENTITY	G_protein-coupled_receptor_30 expression is required for estrogen stimulation of primordial follicle formation in the hamster ovary .
18566133	0	estrogen	10,18	G_protein-coupled_receptor_30	29,58	estrogen	G protein-coupled receptor 30	MESH:D004967	76854(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	The novel estrogen receptor , G_protein-coupled_receptor_30 , mediates the proliferative effects induced by 17beta-estradiol on mouse spermatogonial GC-1 cell line .
19131510	0	estrogen	72,80	G_protein-coupled_receptor_30	15,44	estrogen	G protein-coupled receptor 30	MESH:D004967	2852	Chemical	Gene	action|nmod|START_ENTITY END_ENTITY|nmod|action	Involvement of G_protein-coupled_receptor_30 -LRB- GPR30 -RRB- in rapid action of estrogen in primate LHRH neurons .
25275589	0	estrogen	82,90	G_protein-coupled_receptor_30	18,47	estrogen	G protein-coupled receptor 30	MESH:D004967	2852	Chemical	Gene	cells|amod|START_ENTITY proliferation|nmod|cells inhibits|dobj|proliferation inhibits|nsubj|activation activation|nmod|END_ENTITY	The activation of G_protein-coupled_receptor_30 -LRB- GPR30 -RRB- inhibits proliferation of estrogen receptor-negative breast_cancer cells in vitro and in vivo .
10537130	0	estrogen	86,94	GnRH	61,65	estrogen	GnRH	MESH:D004967	25194(Tax:10116)	Chemical	Gene	receptor-alpha|compound|START_ENTITY expression|nmod|receptor-alpha gene|acl|expression gene|appos|END_ENTITY	Estrogen directly respresses gonadotropin-releasing_hormone -LRB- GnRH -RRB- gene expression in estrogen receptor-alpha -LRB- ERalpha -RRB- - and ERbeta-expressing GT1-7 GnRH neurons .
26365586	0	estrogen	10,18	GnRH	40,44	estrogen	GnRH	MESH:D004967	25194(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	Effect of estrogen on the expression of GnRH and kisspeptin in the hypothalamus of rats during puberty .
17456575	0	estrogen	47,55	Gonadotropin-releasing_hormone	0,30	estrogen	Gonadotropin-releasing hormone	MESH:D004967	2796	Chemical	Gene	receptor-beta|compound|START_ENTITY express|dobj|receptor-beta express|nsubj|neurons neurons|amod|END_ENTITY	Gonadotropin-releasing_hormone neurons express estrogen receptor-beta .
17562336	0	estrogen	66,74	Gonadotropin-releasing_hormone	0,30	estrogen	Gonadotropin-releasing hormone	MESH:D004967	2796	Chemical	Gene	conversion|nmod|START_ENTITY conversion|amod|END_ENTITY	Gonadotropin-releasing_hormone agonist/antagonist conversion with estrogen priming in low responders with prior in vitro fertilization failure .
17881521	0	estrogen	85,93	Gonadotropin-releasing_hormone	0,30	estrogen	Gonadotropin-releasing hormone	MESH:D004967	14714(Tax:10090)	Chemical	Gene	regulated|nmod|START_ENTITY channels|acl:relcl|regulated express|xcomp|channels express|nsubj|neurons neurons|amod|END_ENTITY	Gonadotropin-releasing_hormone neurons express K -LRB- ATP -RRB- channels that are regulated by estrogen and responsive to glucose and metabolic inhibition .
18227283	0	estrogen	94,102	Gonadotropin-releasing_hormone	0,30	estrogen	Gonadotropin-releasing hormone	MESH:D004967	2796	Chemical	Gene	synthesis|compound|START_ENTITY role|nmod|synthesis density|nmod|role regulates|dobj|density regulates|nsubj|END_ENTITY	Gonadotropin-releasing_hormone regulates spine density via its regulatory role in hippocampal estrogen synthesis .
21349822	0	estrogen	61,69	Gper	160,164	estrogen	Gper	MESH:D004967	565271(Tax:7955)	Chemical	Gene	inhibition|compound|START_ENTITY signaling|nmod|inhibition epidermal_growth_factor_receptor|acl|signaling Involvement|nmod|epidermal_growth_factor_receptor mediated|nsubj|Involvement mediated|nmod|G_protein-coupled_estrogen_receptor G_protein-coupled_estrogen_receptor|appos|END_ENTITY	Involvement of epidermal_growth_factor_receptor signaling in estrogen inhibition of oocyte maturation mediated through the G_protein-coupled_estrogen_receptor -LRB- Gper -RRB- in zebrafish -LRB- Danio_rerio -RRB- .
10902791	0	estrogen	64,72	Growth_hormone	0,14	estrogen	Growth hormone	MESH:D004967	2688	Chemical	Gene	replacement|compound|START_ENTITY age|nmod|replacement impact|nmod|age therapy|dep|impact therapy|amod|END_ENTITY	Growth_hormone therapy of Turner_syndrome : the impact of age of estrogen replacement on final height .
163846	0	estrogen	61,69	Growth_hormone	0,14	estrogen	Growth hormone	MESH:D004967	2688	Chemical	Gene	effects|nmod|START_ENTITY release|dep|effects release|amod|END_ENTITY	Growth_hormone release after synthetic 1-24 ACTH : effects of estrogen and sex .
9520907	0	estrogen	60,68	Growth_hormone	0,14	estrogen	Growth hormone	MESH:D004967	2688	Chemical	Gene	therapy|compound|START_ENTITY END_ENTITY|nmod|therapy	Growth_hormone in postmenopausal women after long-term oral estrogen replacement therapy .
17828513	0	estrogen	21,29	HOXA10	73,79	estrogen	HOXA10	MESH:D004967	3206	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|nmod|gene gene|compound|END_ENTITY	Regulatory effect of estrogen , progestin and HB-EGF on the expression of HOXA10 gene in Ishikawa cells .
17975144	0	estrogen	68,76	HOXB13	26,32	estrogen	HOXB13	MESH:D004967	10481	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	The prognostic biomarkers HOXB13 , IL17BR , and CHDH are regulated by estrogen in breast_cancer .
6880465	0	estrogen	18,26	HPL	7,10	estrogen	HPL	MESH:D004967	3956	Chemical	Gene	excretion|compound|START_ENTITY END_ENTITY|appos|excretion	-LSB- Serum HPL , total estrogen excretion and serum oxytocinase in intrauterine_retardation .
11251965	2	estrogen	649,657	HSP90	642,647	estrogen	HSP90	MESH:D004967	3320	Chemical	Gene	receptor|amod|START_ENTITY receptor|dep|END_ENTITY	To further study the possible role of heat_shock proteins -LRB- HSPs -RRB- in growth control , we immunohistochemically analyzed 92 endometrial samples , 30 of normal endometrium , 20 of endometrial_hyperplasia and 42 of endometrial_cancer , for expression of HSP27 , HSP70 , HSP90 , estrogen receptor -LRB- ER -RRB- and progesterone receptor .
12835317	0	estrogen	88,96	Hsp90	30,35	estrogen	Hsp90	MESH:D004967	855836(Tax:4932)	Chemical	Gene	receptor|compound|START_ENTITY involved|nmod|receptor surface|acl|involved reveals|dobj|surface reveals|nsubj|dissection dissection|nmod|p23 p23|appos|cochaperone cochaperone|amod|END_ENTITY	Genetic dissection of p23 , an Hsp90 cochaperone , reveals a distinct surface involved in estrogen receptor signaling .
8832390	0	estrogen	138,146	Hsp90	23,28	estrogen	Hsp90	MESH:D004967	855836(Tax:4932)	Chemical	Gene	receptor|compound|START_ENTITY interaction|nmod|receptor impede|nmod|interaction impede|nsubj|analysis analysis|nmod|dimerization dimerization|amod|END_ENTITY	Mutational analysis of Hsp90 alpha dimerization and subcellular localization : dimer disruption does not impede `` in vivo ' interaction with estrogen receptor .
18229450	0	estrogen	30,38	HspB8	20,25	estrogen	HspB8	MESH:D004967	26353	Chemical	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of Hsp22 -LRB- HspB8 -RRB- by estrogen and the metalloestrogen cadmium in estrogen receptor-positive breast_cancer cells .
23821363	0	estrogen	73,81	IGF-1R	90,96	estrogen	IGF-1R	MESH:D004967	3480	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nmod|END_ENTITY	PDZK1 is a novel factor in breast_cancer that is indirectly regulated by estrogen through IGF-1R and promotes estrogen-mediated growth .
10543935	0	estrogen	119,127	IGF-I	94,99	estrogen	IGF-I	MESH:D004967	3479	Chemical	Gene	receptor|compound|START_ENTITY response|nmod|receptor response|amod|END_ENTITY	IRS-1 expression and activation are not sufficient to activate downstream pathways and enable IGF-I growth response in estrogen receptor negative breast_cancer cells .
12072401	0	estrogen	51,59	IGF-I	27,32	estrogen	IGF-I	MESH:D004967	16000(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY Role|nmod|effects Role|nmod|END_ENTITY	Role of systemic and local IGF-I in the effects of estrogen on growth and epithelial proliferation of mouse uterus .
12629097	0	estrogen	68,76	IGF-I	95,100	estrogen	IGF-I	MESH:D004967	3479	Chemical	Gene	administration|compound|START_ENTITY administration|nmod|END_ENTITY	Effects of recombinant human insulin-like_growth_factor _ -LRB- IGF -RRB- - I and estrogen administration on IGF-I , IGF_binding_protein _ -LRB- IGFBP -RRB- -2 , and IGFBP-3 in anorexia_nervosa : a randomized-controlled study .
14557438	3	estrogen	520,528	IGF-I	604,609	estrogen	IGF-I	MESH:D004967	3479	Chemical	Gene	administration|nmod|START_ENTITY found|nsubjpass|administration found|xcomp|reduce reduce|dobj|levels levels|nmod|END_ENTITY	In contrast , the administration of transdermal estrogen has variably been found to reduce , not change or increase , levels of serum IGF-I .
15217511	0	estrogen	179,187	IGF-I	137,142	estrogen	IGF-I	MESH:D004967	24482(Tax:10116)	Chemical	Gene	activation|amod|START_ENTITY enhances|nmod|activation enhances|nsubj|END_ENTITY	Insulin-like_growth_factor _ -LRB- IGF -RRB- - I obliterates the pregnancy-associated protection against mammary carcinogenesis in rats : evidence that IGF-I enhances cancer progression through estrogen receptor-alpha activation via the mitogen-activated protein kinase pathway .
15809018	0	estrogen	24,32	IGF-I	59,64	estrogen	IGF-I	MESH:D004967	3479	Chemical	Gene	Lack|nmod|START_ENTITY Lack|nmod|END_ENTITY	Lack of synergy between estrogen and progesterone on local IGF-I , IGFBP-3 and IGFBP-2 secretion by both hormone-dependent and hormone-independent breast_cancer explants in vitro .
19585556	0	estrogen	41,49	IGF-I	115,120	estrogen	IGF-I	MESH:D004967	3479	Chemical	Gene	exposure|amod|START_ENTITY exposure|nmod|insulin-like_growth_factor-I insulin-like_growth_factor-I|appos|END_ENTITY	Relationships between critical period of estrogen exposure and circulating levels of insulin-like_growth_factor-I -LRB- IGF-I -RRB- in breast_cancer : evidence from a case-control study .
20962507	0	estrogen	17,25	IGF-I	10,15	estrogen	IGF-I	MESH:D004967	3479	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|appos|receptor	Placental IGF-I , estrogen receptor , and progesterone_receptor expression , and maternal anthropometry in growth-restricted pregnancies in the Swedish population .
8788198	8	estrogen	1156,1164	IGF-I	1094,1099	estrogen	IGF-I	MESH:D004967	24482(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY decrease|nmod|production coincident|nmod|decrease END_ENTITY|acl|coincident	Aromatase mRNA was reduced by IGF-I -LRB- 37 + / - 12 % , p < 0.01 -RRB- , coincident with the decrease in estrogen production .
9056422	0	estrogen	37,45	IGF-I	14,19	estrogen	IGF-I	MESH:D004967	3479	Chemical	Gene	requirements|amod|START_ENTITY reduce|dobj|requirements reduce|nsubj|receptors receptors|compound|END_ENTITY	Overexpressed IGF-I receptors reduce estrogen growth requirements , enhance survival , and promote E-cadherin-mediated cell-cell adhesion in human breast_cancer cells .
22108915	0	estrogen	32,40	IGF1	44,48	estrogen	IGF1	MESH:D004967	3479	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of oral and transdermal estrogen on IGF1 , IGFBP3 , IGFBP1 , serum lipids , and glucose in patients with hypopituitarism during GH treatment : a randomized study .
10102472	0	estrogen	92,100	IL-1beta	66,74	estrogen	IL-1beta	MESH:D004967	3553	Chemical	Gene	attenuated|nmod|START_ENTITY attenuated|nsubjpass|activation activation|nmod|expression expression|nmod|END_ENTITY	The activation of plasminogen_activator_inhibitor-1 expression by IL-1beta is attenuated by estrogen in hepatoblastoma HepG2 cells expressing estrogen_receptor_alpha .
11996939	0	estrogen	14,22	IL-1beta	64,72	estrogen	IL-1beta	MESH:D004967	3553	Chemical	Gene	activity|compound|START_ENTITY Regulation|nmod|activity Regulation|dep|effect effect|nmod|END_ENTITY	Regulation of estrogen activity in human endometrium : effect of IL-1beta on steroid sulfatase activity in human endometrial stromal cells .
18455872	0	estrogen	11,19	IL-1beta	47,55	estrogen	IL-1beta	MESH:D004967	24494(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of estrogen on temporal expressions of IL-1beta and IL-1ra in rat organotypic hippocampal slices exposed to oxygen-glucose_deprivation .
17046061	0	estrogen	65,73	IL-27	105,110	estrogen	IL-27	MESH:D004967	246779(Tax:10090)	Chemical	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	IFN-gamma-inducing transcription factor , T-bet is upregulated by estrogen in murine splenocytes : role of IL-27 but not IL-12 .
25038044	0	estrogen	40,48	Id4	15,18	estrogen	Id4	MESH:D004967	15904(Tax:10090)	Chemical	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Dual roles for Id4 in the regulation of estrogen signaling in the mammary gland and ovary .
18562952	0	estrogen	77,85	Insulin-like_growth_factor-I	0,28	estrogen	Insulin-like growth factor-I	MESH:D004967	3479	Chemical	Gene	engaged|nmod|START_ENTITY responses|acl|engaged inhibits|dobj|responses inhibits|nsubj|END_ENTITY	Insulin-like_growth_factor-I inhibits growth regulatory responses engaged by estrogen and progesterone in the mouse mammary gland .
10777546	0	estrogen	56,64	Insulin_receptor_substrate-1	0,28	estrogen	Insulin receptor substrate-1	MESH:D004967	3667	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	Insulin_receptor_substrate-1 expression is regulated by estrogen in the MCF-7 human breast_cancer cell line .
11162894	0	estrogen	24,32	Interleukin-6	0,13	estrogen	Interleukin-6	MESH:D004967	24498(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY decreases|dobj|production decreases|nsubj|END_ENTITY	Interleukin-6 decreases estrogen production and messenger ribonucleic acid expression encoding aromatase during in vitro cytodifferentiation of rat granulosa cell .
8131749	0	estrogen	68,76	Interleukin-6	0,13	estrogen	Interleukin-6	MESH:D004967	16193(Tax:10090)	Chemical	Gene	depletion|compound|START_ENTITY caused|nmod|depletion bone_loss|acl|caused protected|nmod|bone_loss protected|nsubjpass|mice mice|amod|END_ENTITY	Interleukin-6 deficient mice are protected from bone_loss caused by estrogen depletion .
19625529	0	estrogen	100,108	Kiss1	14,19	estrogen	Kiss1	MESH:D004967	280287(Tax:10090)	Chemical	Gene	pathways|compound|START_ENTITY expression|nmod|pathways expression|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of Kiss1 and dynorphin gene expression in the murine brain by classical and nonclassical estrogen receptor pathways .
20207833	0	estrogen	57,65	Kiss1	13,18	estrogen	Kiss1	MESH:D004967	100144371(Tax:8090)	Chemical	Gene	feedback|compound|START_ENTITY involved|nmod|feedback involved|nsubjpass|END_ENTITY	Hypothalamic Kiss1 but not Kiss2 neurons are involved in estrogen feedback in medaka -LRB- Oryzias_latipes -RRB- .
22505735	4	estrogen	783,791	Kiss1	741,746	estrogen	Kiss1	MESH:D004967	280287(Tax:10090)	Chemical	Gene	deacetylated|nmod|START_ENTITY deacetylated|nsubjpass|histone histone|nmod|region region|compound|END_ENTITY	In contrast , the histone of ARC Kiss1 promoter region was deacetylated by estrogen .
19416165	0	estrogen	46,54	LGR7	17,21	estrogen	LGR7	MESH:D004967	59350	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Relaxin receptor LGR7 -LRB- RXFP1 -RRB- is regulated by estrogen .
12072381	0	estrogen	56,64	LHRH	9,13	estrogen	LHRH	MESH:D004967	2796	Chemical	Gene	transcript|compound|START_ENTITY express|dobj|transcript express|nsubj|neurons neurons|compound|END_ENTITY	Prenatal LHRH neurons in nasal explant cultures express estrogen receptor beta transcript .
17275079	0	estrogen	104,112	LHRH	25,29	estrogen	LHRH	MESH:D004967	25194(Tax:10116)	Chemical	Gene	rats|amod|START_ENTITY signaling|nmod|rats A|acl|signaling activation|nmod|A requires|dobj|activation requires|nsubj|Lordosis Lordosis|acl|facilitation facilitation|nmod|END_ENTITY	Lordosis facilitation by LHRH , PGE2 or db-cAMP requires activation of the kinase A signaling pathway in estrogen primed rats .
2581165	0	estrogen	49,57	LHRH	21,25	estrogen	LHRH	MESH:D004967	25194(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|release release|amod|END_ENTITY	Progesterone-induced LHRH release in vitro is an estrogen -- as well as Ca + + - and calmodulin-dependent secretory process .
2693876	0	estrogen	46,54	LHRH	26,30	estrogen	LHRH	MESH:D004967	25194(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY mRNA|nmod|treatment mRNA|compound|END_ENTITY	In situ hybridization for LHRH mRNA following estrogen treatment .
3288508	0	estrogen	15,23	LHRH	97,101	estrogen	LHRH	MESH:D004967	2796	Chemical	Gene	effect|nmod|START_ENTITY -LSB-|dobj|effect -LSB-|nmod|patterns patterns|nmod|luteinizing_hormone-releasing_hormone luteinizing_hormone-releasing_hormone|appos|END_ENTITY	-LSB- The effect of estrogen on episodic secretory patterns of luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- and luteinizing hormone -LRB- LH -RRB- in hypergonadotropic_hypogonadism -RSB- .
385701	0	estrogen	11,19	LHRH	116,120	estrogen	LHRH	MESH:D004967	25194(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|dep|correlation correlation|nmod|END_ENTITY	Effects of estrogen on 3H-leucine uptake by the hypothalamus and pituitary : correlation with hypothalamic and serum LHRH and LH .
6420719	0	estrogen	9,17	LHRH	57,61	estrogen	LHRH	MESH:D004967	25194(Tax:10116)	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|END_ENTITY	Neonatal estrogen affects preoptic/anterior hypothalamic LHRH differently in adult male and female rats .
6802737	0	estrogen	52,60	LHRH	40,44	estrogen	LHRH	MESH:D004967	2796	Chemical	Gene	therapy|compound|START_ENTITY END_ENTITY|nmod|therapy	Dissociation of LH and FSH Responses to LHRH during estrogen therapy of patients with ovarian_failure .
7627270	0	estrogen	53,61	LHRH	0,4	estrogen	LHRH	MESH:D004967	25194(Tax:10116)	Chemical	Gene	modulated|nmod|START_ENTITY modulated|nsubjpass|effects effects|amod|END_ENTITY	LHRH effects on hippocampal neurons are modulated by estrogen in rats .
17893710	0	estrogen	31,39	LRP16	17,22	estrogen	LRP16	MESH:D004967	28992	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Induction of the LRP16 gene by estrogen promotes the invasive growth of Ishikawa human endometrial_cancer cells through the downregulation of E-cadherin .
10825673	0	estrogen	18,26	Lactoferrin	0,11	estrogen	Lactoferrin	MESH:D004967	17002(Tax:10090)	Chemical	Gene	responsive|amod|START_ENTITY protein|amod|responsive protein|nsubj|END_ENTITY	Lactoferrin is an estrogen responsive protein in the uterus of mice and rats .
3611056	0	estrogen	30,38	Lactotransferrin	0,16	estrogen	Lactotransferrin	MESH:D004967	17002(Tax:10090)	Chemical	Gene	protein|compound|START_ENTITY protein|nsubj|END_ENTITY	Lactotransferrin is the major estrogen inducible protein of mouse uterine secretions .
10965205	0	estrogen	38,46	Leptin	0,6	estrogen	Leptin	MESH:D004967	3952	Chemical	Gene	therapy|amod|START_ENTITY effect|nmod|therapy levels|dep|effect levels|compound|END_ENTITY	Leptin levels in menopause : effect of estrogen replacement therapy .
25433128	0	estrogen	18,26	Leptin	0,6	estrogen	Leptin	MESH:D004967	3952	Chemical	Gene	metabolism|compound|START_ENTITY influences|dobj|metabolism influences|nsubj|END_ENTITY	Leptin influences estrogen metabolism and accelerates prostate cell proliferation .
26286584	0	estrogen	93,101	Leptin	0,6	estrogen	Leptin	MESH:D004967	3952	Chemical	Gene	breast_cancers|compound|START_ENTITY proliferation|nmod|breast_cancers enhances|dobj|proliferation enhances|nsubj|END_ENTITY	Leptin produced by obese adipose stromal/stem cells enhances proliferation and metastasis of estrogen receptor positive breast_cancers .
17463059	0	estrogen	21,29	Lipin1	0,6	estrogen	Lipin1	MESH:D004967	14245(Tax:10090)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Lipin1 regulation by estrogen in uterus and liver : implications for diabetes and fertility .
22143955	0	estrogen	76,84	MLL3	123,127	estrogen	MLL3	MESH:D004967	58508	Chemical	Gene	START_ENTITY|nmod|involvement involvement|nmod|END_ENTITY	HOXC10 is overexpressed in breast_cancer and transcriptionally regulated by estrogen via involvement of histone methylases MLL3 and MLL4 .
16967517	0	estrogen	67,75	MMP-9	14,19	estrogen	MMP-9	MESH:D004967	17395(Tax:10090)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of MMP-9 expression and activity in the mouse uterus by estrogen .
22495744	0	estrogen	14,22	MMP-9	140,145	estrogen	MMP-9	MESH:D004967	4318	Chemical	Gene	GPR30|compound|START_ENTITY expressed|nsubjpass|GPR30 expressed|nmod|cysts cysts|nmod|expression expression|compound|END_ENTITY	Transmembrane estrogen receptor GPR30 is more frequently expressed in malignant than benign ovarian endometriotic cysts and correlates with MMP-9 expression .
22358497	0	estrogen	83,91	NHE3	62,66	estrogen	NHE3	MESH:D004967	105243(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY expression|nmod|receptor expression|appos|END_ENTITY	Estrogen-dependent regulation of sodium/hydrogen exchanger-3 -LRB- NHE3 -RRB- expression via estrogen receptor b in proximal colon of pregnant mice .
17395694	0	estrogen	105,113	NKG2E	138,143	estrogen	NKG2E	MESH:D004967	3823	Chemical	Gene	element|compound|START_ENTITY element|nmod|gene gene|compound|END_ENTITY	Multiple transcription factor elements collaborate with estrogen_receptor_alpha to activate an inducible estrogen response element in the NKG2E gene .
17272673	0	estrogen	12,20	NM23-H2	0,7	estrogen	NM23-H2	MESH:D004967	4831	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|appos|receptor	NM23-H2 , an estrogen receptor beta-associated protein , shows diminished expression with progression of atherosclerosis .
17964137	0	estrogen	27,35	NM23-H2	13,20	estrogen	NM23-H2	MESH:D004967	4831	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	Discovery of NM23-H2 as an estrogen receptor beta-associated protein : role in estrogen-induced gene transcription and cell migration .
20623181	0	estrogen	14,22	NRF2	47,51	estrogen	NRF2	MESH:D004967	4780	Chemical	Gene	signaling|compound|START_ENTITY Inhibition|nmod|signaling activates|nsubj|Inhibition activates|dobj|pathway pathway|compound|END_ENTITY	Inhibition of estrogen signaling activates the NRF2 pathway in breast_cancer .
8341419	0	estrogen	129,137	Neuropeptide	0,12	estrogen	Neuropeptide	MESH:D004967	379044(Tax:10116)	Chemical	Gene	modulation|nmod|START_ENTITY evidence|nmod|modulation co-expression|dep|evidence co-expression|amod|END_ENTITY	Neuropeptide co-expression in the magnocellular neurosecretory system of the female rat : evidence for differential modulation by estrogen .
14522084	0	estrogen	14,22	Nrf2	0,4	estrogen	Nrf2	MESH:D004967	4780	Chemical	Gene	receptor|amod|START_ENTITY END_ENTITY|appos|receptor	Nrf2 , not the estrogen receptor , mediates catechol_estrogen-induced activation of the antioxidant responsive element .
21048224	0	estrogen	29,37	Olfactomedin-4	0,14	estrogen	Olfactomedin-4	MESH:D004967	10562	Chemical	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Olfactomedin-4 regulation by estrogen in the human endometrium requires epidermal growth factor signaling .
20395295	0	estrogen	111,119	Orai3	57,62	estrogen	Orai3	MESH:D004967	93129	Chemical	Gene	receptor-positive|compound|START_ENTITY Orai1|nmod|receptor-positive Orai3|nmod|Orai1 requirement|nmod|Orai3 channel|dep|requirement channel|acl|encoded encoded|nmod|END_ENTITY	A novel native store-operated calcium channel encoded by Orai3 : selective requirement of Orai3 versus Orai1 in estrogen receptor-positive versus estrogen receptor-negative breast_cancer cells .
20395295	0	estrogen	111,119	Orai3	89,94	estrogen	Orai3	MESH:D004967	93129	Chemical	Gene	receptor-positive|compound|START_ENTITY Orai1|nmod|receptor-positive END_ENTITY|nmod|Orai1	A novel native store-operated calcium channel encoded by Orai3 : selective requirement of Orai3 versus Orai1 in estrogen receptor-positive versus estrogen receptor-negative breast_cancer cells .
20395295	0	estrogen	145,153	Orai3	57,62	estrogen	Orai3	MESH:D004967	93129	Chemical	Gene	cells|amod|START_ENTITY receptor-positive|nmod|cells Orai1|nmod|receptor-positive Orai3|nmod|Orai1 requirement|nmod|Orai3 channel|dep|requirement channel|acl|encoded encoded|nmod|END_ENTITY	A novel native store-operated calcium channel encoded by Orai3 : selective requirement of Orai3 versus Orai1 in estrogen receptor-positive versus estrogen receptor-negative breast_cancer cells .
20395295	0	estrogen	145,153	Orai3	89,94	estrogen	Orai3	MESH:D004967	93129	Chemical	Gene	cells|amod|START_ENTITY receptor-positive|nmod|cells Orai1|nmod|receptor-positive END_ENTITY|nmod|Orai1	A novel native store-operated calcium channel encoded by Orai3 : selective requirement of Orai3 versus Orai1 in estrogen receptor-positive versus estrogen receptor-negative breast_cancer cells .
22993197	0	estrogen	12,20	Orai3	0,5	estrogen	Orai3	MESH:D004967	93129	Chemical	Gene	channel|compound|START_ENTITY channel|nsubj|END_ENTITY	Orai3 is an estrogen receptor a-regulated Ca channel that promotes tumorigenesis .
20036346	0	estrogen	99,107	Osteocalcin	0,11	estrogen	Osteocalcin	MESH:D004967	81613(Tax:10116)	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|END_ENTITY	Osteocalcin immunolabeling during the alveolar_healing process in ovariectomized rats treated with estrogen or raloxifene .
11443182	0	estrogen	59,67	Osteoprotegerin	0,15	estrogen	Osteoprotegerin	MESH:D004967	4982	Chemical	Gene	correlation|nmod|START_ENTITY levels|dep|correlation levels|amod|END_ENTITY	Osteoprotegerin serum levels in men : correlation with age , estrogen , and testosterone status .
7228998	0	estrogen	76,84	Oxytocin	0,8	estrogen	Oxytocin	MESH:D004967	5020	Chemical	Gene	correlation|nmod|START_ENTITY END_ENTITY|dep|correlation	Oxytocin in human plasma : correlation with neurophysin and stimulation with estrogen .
25535288	0	estrogen	49,57	PCSK9	73,78	estrogen	PCSK9	MESH:D004967	255738	Chemical	Gene	START_ENTITY|advcl|circulating circulating|dobj|END_ENTITY	Influence of physiological changes in endogenous estrogen on circulating PCSK9 and LDL cholesterol .
18922159	0	estrogen	53,61	PGRMC1	114,120	estrogen	PGRMC1	MESH:D004967	10857	Chemical	Gene	status|compound|START_ENTITY status|nmod|END_ENTITY	Breast_cancer proteomics reveals correlation between estrogen receptor status and differential phosphorylation of PGRMC1 .
17586659	0	estrogen	39,47	PI-3K	137,142	estrogen	PI-3K	MESH:D004967	298947(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY Mechanism|nmod|effects Mechanism|dep|up-regulation up-regulation|nmod|pathway pathway|compound|END_ENTITY	Mechanism of the nongenomic effects of estrogen on intestinal myeloperoxidase activity following trauma-hemorrhage : up-regulation of the PI-3K / Akt pathway .
19851033	0	estrogen	11,19	PMCA_2_and_4	23,35	estrogen	PMCA 2 and 4	MESH:D004967	491;493	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of estrogen on PMCA_2_and_4 in human fibroblast-like synovial cells and mouse macrophage-like cells .
16033082	0	estrogen	69,77	PR	165,167	estrogen	PR	MESH:D004967	5241	Chemical	Gene	alpha|compound|START_ENTITY alpha|appos|END_ENTITY	Normal and malignant human endometrium express immunohistochemically estrogen receptor alpha -LRB- ER-alpha -RRB- , estrogen receptor beta -LRB- ER-beta -RRB- and progesterone_receptor -LRB- PR -RRB- .
21166214	0	estrogen	16,24	PR	66,68	estrogen	PR	MESH:D004967	25154(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	-LSB- The changes of estrogen receptor -LRB- ER -RRB- and progesterone_receptor -LRB- PR -RRB- mRNAs in endometrium with endometriosis -RSB- .
19419938	0	estrogen	29,37	PgR	81,84	estrogen	PgR	MESH:D004967	5241	Chemical	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Differentiated expression of estrogen receptors -LRB- ER -RRB- and progesterone_receptors -LRB- PgR -RRB- in ductal_breast_cancers .
20076999	1	estrogen	224,232	PgR	274,277	estrogen	PgR	MESH:D004967	5241	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Sex steroid hormones and their receptors such as estrogen receptor -LRB- ER -RRB- and progesterone_receptor -LRB- PgR -RRB- have been widely studied for their roles in the etiology of breast_cancer .
7739846	0	estrogen	35,43	PgR	77,80	estrogen	PgR	MESH:D004967	5241	Chemical	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunocytochemical localization of estrogen and progesterone_receptors -LRB- ER _ PgR -RRB- in breast_cancer .
17456783	0	estrogen	82,90	Phosphatidylethanolamine_N-methyltransferase	0,44	estrogen	Phosphatidylethanolamine N-methyltransferase	MESH:D004967	10400	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Phosphatidylethanolamine_N-methyltransferase -LRB- PEMT -RRB- gene expression is induced by estrogen in human and mouse primary hepatocytes .
10797534	0	estrogen	58,66	Phosphatidylinositol_3-kinase	0,29	estrogen	Phosphatidylinositol 3-kinase	MESH:D004967	5293	Chemical	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Phosphatidylinositol_3-kinase mediates neuroprotection by estrogen in cultured cortical neurons .
10624802	0	estrogen	151,159	Prolactin	0,9	estrogen	Prolactin	MESH:D004967	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nsubjpass|secretion secretion|compound|END_ENTITY	Prolactin secretion in response to prolactin-releasing peptide and the expression of the prolactin-releasing peptide gene in the medulla oblongata are estrogen dependent in rats .
2510462	0	estrogen	50,58	Prolactin	0,9	estrogen	Prolactin	MESH:D004967	5617	Chemical	Gene	implants|compound|START_ENTITY levels|nmod|implants levels|compound|END_ENTITY	Prolactin levels in menopausal women on long-term estrogen implants .
6293628	0	estrogen	62,70	Prolactin	0,9	estrogen	Prolactin	MESH:D004967	5617	Chemical	Gene	concentration|amod|START_ENTITY relationship|nmod|concentration binding|dep|relationship binding|compound|END_ENTITY	Prolactin binding by human mammary_carcinoma : relationship to estrogen receptor protein concentration and patient age .
6777214	0	estrogen	24,32	Prolactin	0,9	estrogen	Prolactin	MESH:D004967	24683(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY inhibition|nmod|production inhibition|compound|END_ENTITY	Prolactin inhibition of estrogen production by cultured rat granulosa cells .
7250060	0	estrogen	71,79	Prolactin	0,9	estrogen	Prolactin	MESH:D004967	280901(Tax:9913)	Chemical	Gene	regulation|nmod|START_ENTITY evidence|nmod|regulation synthesis|dep|evidence synthesis|compound|END_ENTITY	Prolactin synthesis in bovine pituitary : no evidence for regulation by estrogen in vivo .
15632153	0	estrogen	30,38	RIP140	20,26	estrogen	RIP140	MESH:D004967	8204	Chemical	Gene	signaling|compound|START_ENTITY END_ENTITY|nmod|signaling	Limiting effects of RIP140 in estrogen signaling : potential mediation of anti-estrogenic effects of retinoic_acid .
25020046	0	estrogen	64,72	SERPINB12	6,15	estrogen	SERPINB12	MESH:D004967	420899(Tax:9031)	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|compound|END_ENTITY	Avian SERPINB12 expression in the avian oviduct is regulated by estrogen and up-regulated in epithelial cell-derived ovarian_carcinomas of laying hens .
19694374	0	estrogen	11,19	SHH	69,72	estrogen	SHH	MESH:D004967	29499(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	-LSB- High-dose estrogen inhibits prostate development by down-regulating SHH signaling in new-born SD rats -RSB- .
12790809	0	estrogen	30,38	SRC1	92,96	estrogen	SRC1	MESH:D004967	10011	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Transcriptional activation by estrogen receptor -LRB- ERalpha -RRB- and steroid_receptor_coactivator -LRB- SRC1 -RRB- involves distinct mechanisms in yeast and mammalian cells .
22328528	0	estrogen	95,103	SRC1	59,63	estrogen	SRC1	MESH:D004967	8648	Chemical	Gene	transcription|amod|START_ENTITY essential|nmod|transcription essential|csubj|Binding Binding|xcomp|exon exon|dobj|21 21|nmod|SRC1e SRC1e|compound|END_ENTITY	Binding of the ERa and ARNT1 AF2 domains to exon 21 of the SRC1 isoform SRC1e is essential for estrogen - and dioxin-related transcription .
8530066	0	estrogen	6,14	STE	38,41	estrogen	STE	MESH:D004967	6783	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Human estrogen sulfotransferase gene -LRB- STE -RRB- : cloning , structure , and chromosomal localization .
20304798	0	estrogen	9,17	SULT1E1	36,43	estrogen	SULT1E1	MESH:D004967	6783	Chemical	Gene	sulfotransferase|compound|START_ENTITY sulfotransferase|appos|END_ENTITY	Specific estrogen sulfotransferase -LRB- SULT1E1 -RRB- substrates and molecular imaging probe candidates .
17981757	0	estrogen	41,49	Soluble_epoxide_hydrolase	0,25	estrogen	Soluble epoxide hydrolase	MESH:D004967	65030(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY END_ENTITY|dep|regulation	Soluble_epoxide_hydrolase : regulation by estrogen and role in the inflammatory response to cerebral_ischemia .
12045172	0	estrogen	84,92	Steroid_receptor_coactivator-3	0,30	estrogen	Steroid receptor coactivator-3	MESH:D004967	17979(Tax:10090)	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Steroid_receptor_coactivator-3 is required for inhibition of neointima formation by estrogen .
20595634	0	estrogen	46,54	Synuclein_gamma	0,15	estrogen	Synuclein gamma	MESH:D004967	6623	Chemical	Gene	stimulates|dobj|START_ENTITY stimulates|nsubj|END_ENTITY	Synuclein_gamma stimulates membrane-initiated estrogen signaling by chaperoning estrogen receptor -LRB- ER -RRB- - alpha36 , a variant of ER-alpha .
17046061	0	estrogen	65,73	T-bet	41,46	estrogen	T-bet	MESH:D004967	57765(Tax:10090)	Chemical	Gene	upregulated|nmod|START_ENTITY upregulated|nsubjpass|END_ENTITY	IFN-gamma-inducing transcription factor , T-bet is upregulated by estrogen in murine splenocytes : role of IL-27 but not IL-12 .
11596108	0	estrogen	90,98	THP-1	118,123	estrogen	THP-1	MESH:D004967	2736	Chemical	Gene	receptors|compound|START_ENTITY receptors|nmod|cells cells|compound|END_ENTITY	Phorbol_diester 12-O-tetradecanoylphorbol_13-acetate -LRB- TPA -RRB- up-regulates the expression of estrogen receptors in human THP-1 leukemia cells .
19329436	0	estrogen	51,59	TRPM6	42,47	estrogen	TRPM6	MESH:D004967	140803	Chemical	Gene	+|nmod|START_ENTITY +|dobj|END_ENTITY	Regulation of the epithelial Mg2 + channel TRPM6 by estrogen and the associated repressor protein of estrogen receptor activity -LRB- REA -RRB- .
24966899	0	estrogen	16,24	TSLP	0,4	estrogen	TSLP	MESH:D004967	85480	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	TSLP induced by estrogen stimulates secretion of MCP-1 and IL-8 and growth of human endometrial stromal cells through JNK and NF-kB signal pathways .
21784129	0	estrogen	34,42	Tumor_necrosis_factor-a	0,23	estrogen	Tumor necrosis factor-a	MESH:D004967	7124	Chemical	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Tumor_necrosis_factor-a activates estrogen signaling pathways in endometrial epithelial cells via estrogen_receptor_a .
17174996	0	estrogen	75,83	UDP-glucuronosyltransferase_1A10	110,142	estrogen	UDP-glucuronosyltransferase 1A10	MESH:D004967	54575	Chemical	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Phenylalanine -LRB- 90 -RRB- and phenylalanine -LRB- 93 -RRB- are crucial amino_acids within the estrogen binding site of the human UDP-glucuronosyltransferase_1A10 .
26528103	0	estrogen	17,25	UGT2B17	57,64	estrogen	UGT2B17	MESH:D004967	7367	Chemical	Gene	Polymorphisms|nmod|START_ENTITY metabolism-related|nsubj|Polymorphisms metabolism-related|ccomp|associated associated|nsubjpass|genes genes|nummod|END_ENTITY	Polymorphisms of estrogen metabolism-related genes ESR1 , UGT2B17 , and UGT1A1 are not associated with osteoporosis in surgically menopausal Japanese women .
19186013	0	estrogen	53,61	VEGF	103,107	estrogen	VEGF	MESH:D004967	403802(Tax:9615)	Chemical	Gene	antagonists|compound|START_ENTITY effects|nmod|antagonists effects|nmod|END_ENTITY	Gender-related effects of prenatal administration of estrogen and progesterone_receptor antagonists on VEGF and surfactant-proteins and on alveolarisation in the developing piglet lung .
21240521	0	estrogen	26,34	VEGF	57,61	estrogen	VEGF	MESH:D004967	281572(Tax:9913)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	The contrasting effect of estrogen on mRNA expression of VEGF in bovine retinal_vascular endothelial cells under different oxygen conditions .
10810312	0	estrogen	101,109	Vascular_endothelial_growth_factor	0,34	estrogen	Vascular endothelial growth factor	MESH:D004967	83785(Tax:10116)	Chemical	Gene	distribution|nmod|START_ENTITY END_ENTITY|dep|distribution	Vascular_endothelial_growth_factor in the rat pituitary : differential distribution and regulation by estrogen .
18497067	0	estrogen	56,64	Vascular_endothelial_growth_factor	0,34	estrogen	Vascular endothelial growth factor	MESH:D004967	7422	Chemical	Gene	receptor|compound|START_ENTITY gene|nmod|receptor gene|nsubj|END_ENTITY	Vascular_endothelial_growth_factor is a target gene for estrogen receptor and contributes to breast_cancer progression .
17660348	0	estrogen	43,51	X-box_binding_protein-1	6,29	estrogen	X-box binding protein-1	MESH:D004967	7494	Chemical	Gene	independence|compound|START_ENTITY confers|dobj|independence confers|nsubj|END_ENTITY	Human X-box_binding_protein-1 confers both estrogen independence and antiestrogen resistance in breast_cancer cell lines .
21984905	0	estrogen	62,70	XAP2	30,34	estrogen	XAP2	MESH:D004967	9049	Chemical	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	The immunophilin-like protein XAP2 is a negative regulator of estrogen signaling through interaction with estrogen_receptor_a .
23159625	0	estrogen	33,41	Zinc_finger_protein_131	0,23	estrogen	Zinc finger protein 131	MESH:D004967	7690	Chemical	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Zinc_finger_protein_131 inhibits estrogen signaling by suppressing estrogen_receptor_a homo-dimerization .
3454873	0	estrogen	92,100	albumin	34,41	estrogen	albumin	MESH:D004967	448844(Tax:8355)	Chemical	Gene	mechanism|amod|START_ENTITY evidence|nmod|mechanism regulation|dep|evidence regulation|nmod|expression expression|compound|END_ENTITY	Posttranscriptional regulation of albumin gene expression in Xenopus liver : evidence for an estrogen receptor-dependent mechanism .
3956852	0	estrogen	82,90	albumin	55,62	estrogen	albumin	MESH:D004967	448844(Tax:8355)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Transcriptional and post-transcriptional inhibition of albumin gene expression by estrogen in Xenopus liver .
6164370	0	estrogen	35,43	alpha-fetoprotein	59,76	estrogen	alpha-fetoprotein	MESH:D004967	24177(Tax:10116)	Chemical	Gene	START_ENTITY|amod|binding binding|nmod|END_ENTITY	Diethylpyrocarbonate inhibition of estrogen binding to rat alpha-fetoprotein : evidence that one or more histidine residues regulate estrogen binding .
18804812	0	estrogen	11,19	alpha1A-adrenergic_receptor	55,82	estrogen	alpha1A-adrenergic receptor	MESH:D004967	29413(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|amod|END_ENTITY	Effects of estrogen , raloxifene and levormeloxifene on alpha1A-adrenergic_receptor expression .
11458115	0	estrogen	42,50	androgen_receptor	19,36	estrogen	androgen receptor	MESH:D004967	24208(Tax:10116)	Chemical	Gene	beta|compound|START_ENTITY Co-localization|nmod|beta Co-localization|nmod|END_ENTITY	Co-localization of androgen_receptor with estrogen receptor beta in the lower urinary tract of the male rat .
12960060	0	estrogen	9,17	androgen_receptor	43,60	estrogen	androgen receptor	MESH:D004967	24208(Tax:10116)	Chemical	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|END_ENTITY	Neonatal estrogen down-regulates prostatic androgen_receptor through a proteosome-mediated protein degradation pathway .
14755534	0	estrogen	93,101	androgen_receptor	14,31	estrogen	androgen receptor	MESH:D004967	751774(Tax:59729)	Chemical	Gene	regulation|nmod|START_ENTITY Expression|dep|regulation Expression|nmod|mRNA mRNA|compound|END_ENTITY	Expression of androgen_receptor mRNA in zebra_finch song system : developmental regulation by estrogen .
15028522	0	estrogen	117,125	androgen_receptor	71,88	estrogen	androgen receptor	MESH:D004967	751774(Tax:59729)	Chemical	Gene	receptor|compound|START_ENTITY expression|nmod|receptor mRNA|appos|expression mRNA|compound|END_ENTITY	Steroid receptors in the adult zebra_finch syrinx : a sex difference in androgen_receptor mRNA , minimal expression of estrogen receptor alpha and aromatase .
1547747	0	estrogen	9,17	androgen_receptor	83,100	estrogen	androgen receptor	MESH:D004967	24208(Tax:10116)	Chemical	Gene	exposure|compound|START_ENTITY induces|nsubj|exposure induces|dobj|alterations alterations|nmod|expression expression|compound|END_ENTITY	Neonatal estrogen exposure induces lobe-specific alterations in adult rat prostate androgen_receptor expression .
15711965	0	estrogen	98,106	androgen_receptor	68,85	estrogen	androgen receptor	MESH:D004967	751774(Tax:59729)	Chemical	Gene	alpha|dep|START_ENTITY alpha|compound|END_ENTITY	Post-hatching syrinx development in the zebra_finch : an analysis of androgen_receptor , aromatase , estrogen receptor alpha and estrogen receptor beta mRNAs .
1597166	0	estrogen	9,17	androgen_receptor	83,100	estrogen	androgen receptor	MESH:D004967	24208(Tax:10116)	Chemical	Gene	exposure|compound|START_ENTITY induces|nsubj|exposure induces|dobj|alterations alterations|nmod|expression expression|compound|END_ENTITY	Neonatal estrogen exposure induces lobe-specific alterations in adult rat prostate androgen_receptor expression .
17585029	0	estrogen	93,101	androgen_receptor	47,64	estrogen	androgen receptor	MESH:D004967	367	Chemical	Gene	expression|amod|START_ENTITY altering|dobj|expression isolate|advcl|altering isolate|dobj|expression expression|compound|END_ENTITY	Isoflavone-rich soy protein isolate suppresses androgen_receptor expression without altering estrogen receptor-beta expression or serum hormonal profiles in men at high risk of prostate_cancer .
18516291	0	estrogen	86,94	androgen_receptor	46,63	estrogen	androgen receptor	MESH:D004967	367	Chemical	Gene	breast_cancer|compound|START_ENTITY pathways|nmod|breast_cancer pathways|nsubj|cross-talk cross-talk|nmod|END_ENTITY	A functionally significant cross-talk between androgen_receptor and ErbB2 pathways in estrogen receptor negative breast_cancer .
18840639	0	estrogen	10,18	androgen_receptor	83,100	estrogen	androgen receptor	MESH:D004967	367	Chemical	Gene	associated|nsubjpass|START_ENTITY associated|nmod|repeats repeats|compound|END_ENTITY	Increased estrogen rather than decreased androgen action is associated with longer androgen_receptor CAG repeats .
20223236	0	estrogen	30,38	androgen_receptor	11,28	estrogen	androgen receptor	MESH:D004967	24208(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|appos|receptor	Changes in androgen_receptor , estrogen receptor alpha , and sexual_behavior with aging and testosterone in male rats .
2046857	0	estrogen	22,30	androgen_receptor	65,82	estrogen	androgen receptor	MESH:D004967	24208(Tax:10116)	Chemical	Gene	influence|nmod:poss|START_ENTITY influence|nmod|END_ENTITY	A characterization of estrogen 's influence on anterior pituitary androgen_receptor : effect of bromocriptine treatment .
21457548	0	estrogen	88,96	androgen_receptor	30,47	estrogen	androgen receptor	MESH:D004967	367	Chemical	Gene	breast_cancer|amod|START_ENTITY implications|nmod|breast_cancer has|dobj|implications has|nsubj|Synergy Synergy|nmod|inhibitors inhibitors|nmod|END_ENTITY	Synergy between inhibitors of androgen_receptor and MEK has therapeutic implications in estrogen receptor-negative breast_cancer .
21967219	0	estrogen	68,76	androgen_receptor	22,39	estrogen	androgen receptor	MESH:D004967	367	Chemical	Gene	alpha|dep|START_ENTITY aromatase|dobj|alpha aromatase|nsubj|Immunolocalization Immunolocalization|nmod|END_ENTITY	Immunolocalization of androgen_receptor , aromatase cytochrome P450 , estrogen receptor alpha and estrogen receptor beta proteins during the breeding season in scent glands of muskrats -LRB- Ondatra zibethicus -RRB- .
23009195	0	estrogen	41,49	androgen_receptor	22,39	estrogen	androgen receptor	MESH:D004967	367	Chemical	Gene	proteins|dep|START_ENTITY proteins|compound|END_ENTITY	Immunoreactivities of androgen_receptor , estrogen receptors , p450arom , p450c17 proteins in wild ground squirrels ovaries during the nonbreeding and breeding seasons .
24850180	0	estrogen	25,33	androgen_receptor	75,92	estrogen	androgen receptor	MESH:D004967	367	Chemical	Gene	breast_cancer|amod|START_ENTITY differences|nmod|breast_cancer based|nsubj|differences based|nmod|status status|compound|END_ENTITY	Metabolic differences in estrogen receptor-negative breast_cancer based on androgen_receptor status .
3314266	0	estrogen	15,23	androgen_receptor	77,94	estrogen	androgen receptor	MESH:D004967	367	Chemical	Gene	protein|compound|START_ENTITY protein|dep|comparison comparison|nmod|END_ENTITY	Immunoreactive estrogen receptor protein in meningiomas : comparison with the androgen_receptor and progesterone receptor binding activity .
6604842	0	estrogen	95,103	androgen_receptor	123,140	estrogen	androgen receptor	MESH:D004967	367	Chemical	Gene	treatment|compound|START_ENTITY increase|nsubj|treatment increase|dobj|content content|compound|END_ENTITY	Concentration and cellular distribution of androgen_receptor in human prostatic_neoplasia : can estrogen treatment increase androgen_receptor content ?
6604842	0	estrogen	95,103	androgen_receptor	43,60	estrogen	androgen receptor	MESH:D004967	367	Chemical	Gene	treatment|compound|START_ENTITY increase|nsubj|treatment increase|dep|distribution distribution|nmod|END_ENTITY	Concentration and cellular distribution of androgen_receptor in human prostatic_neoplasia : can estrogen treatment increase androgen_receptor content ?
7502692	0	estrogen	27,35	androgen_receptor	60,77	estrogen	androgen receptor	MESH:D004967	367	Chemical	Gene	effects|compound|START_ENTITY implications|nmod|effects implications|nmod|END_ENTITY	Biological implications of estrogen and androgen effects on androgen_receptor and its mRNA levels in human uterine endometrium .
7867585	0	estrogen	118,126	androgen_receptor	29,46	estrogen	androgen receptor	MESH:D004967	24208(Tax:10116)	Chemical	Gene	altered|nmod|START_ENTITY altered|nsubjpass|pattern pattern|nmod|expression expression|compound|END_ENTITY	The developmental pattern of androgen_receptor expression in rat prostate lobes is altered after neonatal exposure to estrogen .
8369523	0	estrogen	58,66	androgen_receptor	146,163	estrogen	androgen receptor	MESH:D004967	367	Chemical	Gene	cells|amod|START_ENTITY cells|nmod|END_ENTITY	Medroxyprogesterone_acetate inhibits the proliferation of estrogen - and progesterone-receptor negative MFM-223 human mammary cancer cells via the androgen_receptor .
9521507	1	estrogen	132,140	androgen_receptor	87,104	estrogen	androgen receptor	MESH:D004967	367	Chemical	Gene	loss|nmod|START_ENTITY accompanied|nmod|loss accompanied|nsubj|over-expression over-expression|nmod|END_ENTITY	Consistent over-expression of androgen_receptor accompanied by the loss of estrogen and progesterone_receptors in apocrine metaplasia and apocrine_carcinoma in situ .
9593644	0	estrogen	103,111	androgen_receptor	77,94	estrogen	androgen receptor	MESH:D004967	367	Chemical	Gene	downregulation|nmod|START_ENTITY downregulation|nmod|mRNA mRNA|compound|END_ENTITY	Autoregulation of estrogen and androgen_receptor mRNAs and downregulation of androgen_receptor mRNA by estrogen in primary cultures of lizard testis cells .
1334045	0	estrogen	10,18	angiotensin_converting_enzyme	22,51	estrogen	angiotensin converting enzyme	MESH:D004967	1636	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of estrogen on angiotensin_converting_enzyme in immature quail oviduct .
20462965	0	estrogen	13,21	angiotensinogen	58,73	estrogen	angiotensinogen	MESH:D004967	183	Chemical	Gene	depletion|compound|START_ENTITY Influence|nmod|depletion Influence|acl|loading loading|nmod|expression expression|compound|END_ENTITY	Influence of estrogen depletion and salt loading on renal angiotensinogen expression in the mRen -LRB- 2 -RRB- .
196473	0	estrogen	23,31	antithrombin	35,47	estrogen	antithrombin	MESH:D004967	462	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Inhibitory effects of estrogen on antithrombin III -LRB- author 's transl -RRB- -RSB- .
9056393	0	estrogen	36,44	apoE	60,64	estrogen	apoE	MESH:D004967	25728(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|mRNA mRNA|amod|END_ENTITY	Astrocytes and microglia respond to estrogen with increased apoE mRNA in vivo and in vitro .
6872953	2	estrogen	282,290	apoVLDL-II	263,273	estrogen	apoVLDL-II	MESH:D004967	396476(Tax:9031)	Chemical	Gene	treatment|compound|START_ENTITY mRNA|nmod|treatment mRNA|compound|END_ENTITY	The response of apoVLDL-II mRNA to estrogen treatment in 5-week-old cockerels was studied by hybridization to a nick-translated probe from cloned apoVLDL-II DNA .
12788226	0	estrogen	14,22	apolipoprotein_A-I	53,71	estrogen	apolipoprotein A-I	MESH:D004967	396536(Tax:9031)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation by estrogen of synthesis and secretion of apolipoprotein_A-I in the chicken hepatoma cell line , LMH-2A .
16339502	0	estrogen	12,20	apolipoprotein_A-I	70,88	estrogen	apolipoprotein A-I	MESH:D004967	335	Chemical	Gene	START_ENTITY|nmod|therapy therapy|nmod|END_ENTITY	Role of the estrogen and progestin in hormonal replacement therapy on apolipoprotein_A-I kinetics in postmenopausal women .
10703933	0	estrogen	50,58	apolipoprotein_E	92,108	estrogen	apolipoprotein E	MESH:D004967	348	Chemical	Gene	status|compound|START_ENTITY status|dep|modifies modifies|dobj|influence influence|nmod|END_ENTITY	Apolipoprotein_E gene polymorphism and bone_loss : estrogen status modifies the influence of apolipoprotein_E on bone_loss .
11723172	0	estrogen	81,89	apolipoprotein_E	45,61	estrogen	apolipoprotein E	MESH:D004967	11816(Tax:10090)	Chemical	Gene	treatments|compound|START_ENTITY END_ENTITY|nmod|treatments	Brain region-specific up-regulation of mouse apolipoprotein_E by pharmacological estrogen treatments .
17077142	0	estrogen	14,22	apolipoprotein_E	85,101	estrogen	apolipoprotein E	MESH:D004967	25728(Tax:10116)	Chemical	Gene	increases|amod|START_ENTITY Activation|nmod|increases decreases|nsubj|Activation decreases|dobj|expression expression|amod|END_ENTITY	Activation of estrogen receptor alpha increases and estrogen receptor beta decreases apolipoprotein_E expression in hippocampus in vitro and in vivo .
2494081	0	estrogen	27,35	apolipoprotein_E	49,65	estrogen	apolipoprotein E	MESH:D004967	348	Chemical	Gene	Relationship|nmod|START_ENTITY Relationship|nmod|END_ENTITY	Relationship between serum estrogen and level of apolipoprotein_E in human ovarian follicular fluid .
9075616	0	estrogen	10,18	apolipoprotein_E	111,127	estrogen	apolipoprotein E	MESH:D004967	348	Chemical	Gene	therapy|amod|START_ENTITY Effect|nmod|therapy Effect|nmod|END_ENTITY	Effect of estrogen replacement therapy on hepatic_triglyceride_lipase , lipoprotein_lipase and lipids including apolipoprotein_E in climacteric and elderly women .
16999734	0	estrogen	105,113	aquaporin_5	68,79	estrogen	aquaporin 5	MESH:D004967	11830(Tax:10090)	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Chromatin immunoprecipitation-mediated target identification proved aquaporin_5 is regulated directly by estrogen in the uterus .
10619402	0	estrogen	115,123	aryl_hydrocarbon_receptor	4,29	estrogen	aryl hydrocarbon receptor	MESH:D004967	196	Chemical	Gene	elements|amod|START_ENTITY occurring|dobj|elements interacts|advcl|occurring interacts|nsubj|heterodimer heterodimer|compound|END_ENTITY	The aryl_hydrocarbon_receptor -LRB- AHR -RRB- / AHR nuclear translocator -LRB- ARNT -RRB- heterodimer interacts with naturally occurring estrogen response elements .
16191477	0	estrogen	46,54	aryl_hydrocarbon_receptor	83,108	estrogen	aryl hydrocarbon receptor	MESH:D004967	100066186(Tax:9796)	Chemical	Gene	equilenin|compound|START_ENTITY equilenin|appos|END_ENTITY	Induction of cytochrome P450-1A by the equine estrogen equilenin , a new endogenous aryl_hydrocarbon_receptor ligand .
21828262	0	estrogen	14,22	aryl_hydrocarbon_receptor	112,137	estrogen	aryl hydrocarbon receptor	MESH:D004967	196	Chemical	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|dep|role role|nmod|END_ENTITY	Regulation of estrogen sulfotransferase expression by confluence of MCF10A breast epithelial cells : role of the aryl_hydrocarbon_receptor .
22295239	0	estrogen	57,65	aryl_hydrocarbon_receptor	12,37	estrogen	aryl hydrocarbon receptor	MESH:D004967	196	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	The role of aryl_hydrocarbon_receptor and crosstalk with estrogen receptor in response of breast_cancer cells to the novel antitumor agents benzothiazoles and aminoflavone .
10414967	0	estrogen	69,77	bcl-2	20,25	estrogen	bcl-2	MESH:D004967	24224(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY role|nmod|receptors modulates|dep|role modulates|amod|END_ENTITY	Estradiol modulates bcl-2 in cerebral_ischemia : a potential role for estrogen receptors .
11477803	0	estrogen	19,27	bcl-2	45,50	estrogen	bcl-2	MESH:D004967	596	Chemical	Gene	regulation|nmod|START_ENTITY -LSB-|dobj|regulation -LSB-|nmod|oncogene oncogene|amod|END_ENTITY	-LSB- The regulation of estrogen and tamoxifen to bcl-2 oncogene in endometrial_carcinoma -RSB- .
15871186	0	estrogen	22,30	bcl-2	74,79	estrogen	bcl-2	MESH:D004967	24224(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY Effects|nmod|treatment Effects|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of long-term estrogen replacement treatment on the expression of bcl-2 and H-ras in rat endometrium -RSB- .
20857269	6	estrogen	967,975	bcl-2	949,954	estrogen	MIB-1	MESH:D004967	57534	Chemical	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Immunohistochemically , the fibroblastic or myofibroblastic spindle cells were positive for vimentin , a-smooth muscle actin , and Ki-67 -LRB- MIB-1 -RRB- but negative for desmin , pan-cytokeratin , S-100 protein , CD34 , CD68 , CD99 , bcl-2 , b-catenin , estrogen receptor , progesterone receptor , ALK-1 , and p53 .
21695979	0	estrogen	34,42	bcl-2	27,32	estrogen	bcl-2	MESH:D004967	596	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	-LSB- Expression of Ki-67 , p53 , bcl-2 , estrogen receptors alpha in patients with clear_cell_renal_carcinoma and epidermal_growth_factor_receptor mutation -RSB- .
10629227	0	estrogen	43,51	beta-catenin	106,118	estrogen	beta-catenin	MESH:D004967	1499	Chemical	Gene	activation|compound|START_ENTITY transition|nmod|activation involves|nsubj|transition involves|dobj|translocation translocation|nmod|END_ENTITY	Epithelial mesenchymal transition by c-Fos estrogen receptor activation involves nuclear translocation of beta-catenin and upregulation of beta-catenin/lymphoid enhancer binding factor-1 transcriptional activity .
15257551	0	estrogen	123,131	beta-catenin	145,157	estrogen	beta-catenin	MESH:D004967	1499	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Biotin-rich , optically clear nuclei express estrogen receptor-beta : tumors with morules may develop under the influence of estrogen and aberrant beta-catenin expression .
15257551	0	estrogen	44,52	beta-catenin	145,157	estrogen	beta-catenin	MESH:D004967	1499	Chemical	Gene	receptor-beta|compound|START_ENTITY express|dobj|receptor-beta express|parataxis|develop develop|nmod|influence influence|nmod|expression expression|compound|END_ENTITY	Biotin-rich , optically clear nuclei express estrogen receptor-beta : tumors with morules may develop under the influence of estrogen and aberrant beta-catenin expression .
20042609	0	estrogen	69,77	beta-catenin	284,296	estrogen	beta-catenin	MESH:D004967	84353(Tax:10116)	Chemical	Gene	control|compound|START_ENTITY control|dep|sensitivity sensitivity|acl|leading leading|xcomp|phosphatidylinositol phosphatidylinositol|dobj|activation activation|nmod|signaling signaling|amod|END_ENTITY	Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like_growth_factor _ -LRB- IGF -RRB- _ I_receptor sensitivity to Ambient IGF , leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 receptor-independent activation of beta-catenin signaling .
23159989	0	estrogen	76,84	beta-defensin_11	29,45	estrogen	beta-defensin 11	MESH:D004967	414876(Tax:9031)	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression and regulation of beta-defensin_11 in the oviduct in response to estrogen and in ovarian_tumors of chickens .
10536257	0	estrogen	15,23	brain-derived_neurotrophic_factor	68,101	estrogen	brain-derived neurotrophic factor	MESH:D004967	24225(Tax:10116)	Chemical	Gene	Treatment|nmod|START_ENTITY affects|nsubj|Treatment affects|dobj|levels levels|nmod|mRNA mRNA|amod|END_ENTITY	Treatment with estrogen and progesterone affects relative levels of brain-derived_neurotrophic_factor mRNA and protein in different regions of the adult rat brain .
14681930	0	estrogen	52,60	brain-derived_neurotrophic_factor	64,97	estrogen	brain-derived neurotrophic factor	MESH:D004967	627	Chemical	Gene	evidence|nmod|START_ENTITY evidence|nmod|expression expression|amod|END_ENTITY	Anatomical evidence for transsynaptic influences of estrogen on brain-derived_neurotrophic_factor expression .
16179807	0	estrogen	11,19	brain-derived_neurotrophic_factor	47,80	estrogen	brain-derived neurotrophic factor	MESH:D004967	24225(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY Effects|nmod|treatment Effects|nmod|expression expression|amod|END_ENTITY	Effects of estrogen treatment on expression of brain-derived_neurotrophic_factor and cAMP_response_element-binding_protein expression and phosphorylation in rat amygdaloid and hippocampal structures .
7479947	0	estrogen	29,37	brain-derived_neurotrophic_factor	76,109	estrogen	brain-derived neurotrophic factor	MESH:D004967	627	Chemical	Gene	element|compound|START_ENTITY element|nmod|END_ENTITY	Identification of a putative estrogen response element in the gene encoding brain-derived_neurotrophic_factor .
19718764	0	estrogen	50,58	brain_aromatase	20,35	estrogen	brain aromatase	MESH:D004967	60640(Tax:7955)	Chemical	Gene	receptors|compound|START_ENTITY regulation|nmod|receptors regulation|nmod|END_ENTITY	Early regulation of brain_aromatase -LRB- cyp19a1b -RRB- by estrogen receptors during zebrafish development .
10629227	0	estrogen	43,51	c-Fos	37,42	estrogen	c-Fos	MESH:D004967	2353	Chemical	Gene	activation|compound|START_ENTITY activation|amod|END_ENTITY	Epithelial mesenchymal transition by c-Fos estrogen receptor activation involves nuclear translocation of beta-catenin and upregulation of beta-catenin/lymphoid enhancer binding factor-1 transcriptional activity .
22884659	0	estrogen	18,26	c-MYC	55,60	estrogen	c-MYC	MESH:D004967	4609	Chemical	Gene	receptors|compound|START_ENTITY expression|nmod|receptors expression|appos|genes genes|amod|END_ENTITY	The expression of estrogen receptors as well as GREB1 , c-MYC , and cyclin_D1 , estrogen-regulated genes implicated in proliferation , is increased in peritoneal endometriosis .
15757889	0	estrogen	48,56	c-Myc	0,5	estrogen	c-Myc	MESH:D004967	4609	Chemical	Gene	signaling|compound|START_ENTITY suppresses|nmod|signaling suppresses|nsubj|END_ENTITY	c-Myc suppresses p21WAF1/CIP1 expression during estrogen signaling and antiestrogen resistance in human breast_cancer cells .
9671459	0	estrogen	26,34	c-Myc	0,5	estrogen	c-Myc	MESH:D004967	4609	Chemical	Gene	effects|compound|START_ENTITY mimics|dobj|effects mimics|nsubj|END_ENTITY	c-Myc or cyclin_D1 mimics estrogen effects on cyclin E-Cdk2 activation and cell cycle reentry .
17172405	0	estrogen	81,89	c-Src	36,41	estrogen	c-Src	MESH:D004967	6714	Chemical	Gene	growth|nmod|START_ENTITY preventing|dobj|growth inhibition|advcl|preventing cells|amod|inhibition cells|amod|END_ENTITY	Cooperative action of tamoxifen and c-Src inhibition in preventing the growth of estrogen receptor-positive human breast_cancer cells .
24486401	0	estrogen	146,154	c-Src	126,131	estrogen	c-Src	MESH:D004967	6714	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Sphingosine kinase 2 prevents the nuclear translocation of sphingosine_1-phosphate_receptor-2 and tyrosine 416 phosphorylated c-Src and increases estrogen receptor negative MDA-MB-231_breast_cancer cell growth : The role of sphingosine_1-phosphate receptor-4 .
16188438	0	estrogen	44,52	c-erbB-2	113,121	estrogen	c-erbB-2	MESH:D004967	2064	Chemical	Gene	receptor|compound|START_ENTITY receptors|dep|receptor receptors|dep|END_ENTITY	Co-expression of steroid hormone receptors -LRB- estrogen receptor alpha and/or progesterone receptors -RRB- and Her2/neu -LRB- c-erbB-2 -RRB- in breast_cancer : clinical outcome following tamoxifen-based adjuvant therapy .
10971144	0	estrogen	51,59	c-fos	29,34	estrogen	c-fos	MESH:D004967	314322(Tax:10116)	Chemical	Gene	neurons|amod|START_ENTITY stimulates|nmod|neurons stimulates|dobj|activity activity|amod|END_ENTITY	Maternal behavior stimulates c-fos activity within estrogen receptor alpha-containing neurons in lactating rats .
12727818	0	estrogen	26,34	c-fos	105,110	estrogen	c-fos	MESH:D004967	2353	Chemical	Gene	element|compound|START_ENTITY decoy|nmod|element suppresses|nsubj|decoy suppresses|dobj|cells cells|nmod|target target|acl|disrupting disrupting|dobj|END_ENTITY	The cis decoy against the estrogen response element suppresses breast_cancer cells via target disrupting c-fos not mitogen-activated protein kinase activity .
1371505	0	estrogen	63,71	c-fos	14,19	estrogen	c-fos	MESH:D004967	2353	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|levels levels|amod|END_ENTITY	Regulation of c-fos and ornithine_decarboxylase mRNA levels by estrogen and 5-azacytidine .
1517237	0	estrogen	21,29	c-fos	87,92	estrogen	c-fos	MESH:D004967	14281(Tax:10090)	Chemical	Gene	element|amod|START_ENTITY Identification|nmod|element Identification|dep|region region|nmod|protooncogene protooncogene|amod|END_ENTITY	Identification of an estrogen response element in the 3 ' - flanking region of the murine c-fos protooncogene .
16844660	0	estrogen	50,58	c-fos	43,48	estrogen	c-fos	MESH:D004967	314322(Tax:10116)	Chemical	Gene	receptoralpha|amod|START_ENTITY receptoralpha|amod|END_ENTITY	Comparative expression and distribution of c-fos , estrogen receptoralpha -LRB- eralpha -RRB- , and p38alpha in the uterus of rats , monkeys , and humans .
19199093	0	estrogen	77,85	c-fos	0,5	estrogen	c-fos	MESH:D004967	2353	Chemical	Gene	action|compound|START_ENTITY marker|nmod|action gene|dep|marker gene|amod|END_ENTITY	c-fos gene and protein expression in pelvic_endometriosis : a local marker of estrogen action .
2119495	0	estrogen	21,29	c-fos	69,74	estrogen	c-fos	MESH:D004967	2353	Chemical	Gene	element|compound|START_ENTITY Identification|nmod|element upstream|nsubj|Identification upstream|nmod|gene gene|amod|END_ENTITY	Identification of an estrogen response element upstream of the human c-fos gene that binds the estrogen_receptor and the AP-1 transcription factor .
2318256	0	estrogen	19,27	c-fos	0,5	estrogen	c-fos	MESH:D004967	314322(Tax:10116)	Chemical	Gene	induction|nmod|START_ENTITY induction|nsubj|END_ENTITY	c-fos induction by estrogen in specific rat brain areas .
2507374	0	estrogen	18,26	c-fos	30,35	estrogen	c-fos	MESH:D004967	2353	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|amod|END_ENTITY	Direct effects of estrogen on c-fos and c-myc protooncogene expression and cellular proliferation in human breast_cancer cells .
8136308	0	estrogen	32,40	c-fos	133,138	estrogen	c-fos	MESH:D004967	14281(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY interaction|nmod|receptor present|nmod|interaction present|nmod|3 3|dep|region region|nmod|protooncogene protooncogene|amod|END_ENTITY	In vitro interaction of uterine estrogen receptor with the estrogen response element present in the 3 ' - flanking region of the murine c-fos protooncogene .
8136308	0	estrogen	59,67	c-fos	133,138	estrogen	c-fos	MESH:D004967	14281(Tax:10090)	Chemical	Gene	receptor|nmod|START_ENTITY interaction|nmod|receptor present|nmod|interaction present|nmod|3 3|dep|region region|nmod|protooncogene protooncogene|amod|END_ENTITY	In vitro interaction of uterine estrogen receptor with the estrogen response element present in the 3 ' - flanking region of the murine c-fos protooncogene .
8940373	0	estrogen	103,111	c-fos	46,51	estrogen	c-fos	MESH:D004967	14281(Tax:10090)	Chemical	Gene	stimulation|compound|START_ENTITY protooncogenes|nmod|stimulation protooncogenes|nsubj|expression expression|nmod|END_ENTITY	Temporal and cell-type specific expression of c-fos and c-jun protooncogenes in the mouse uterus after estrogen stimulation .
9112413	0	estrogen	70,78	c-fos	27,32	estrogen	c-fos	MESH:D004967	314322(Tax:10116)	Chemical	Gene	gland|nmod|START_ENTITY induction|nmod|gland induction|nmod|expression expression|amod|END_ENTITY	Cell-specific induction of c-fos expression in the pituitary gland by estrogen .
1630819	0	estrogen	13,21	c-myc	36,41	estrogen	c-myc	MESH:D004967	4609	Chemical	Gene	activation|compound|START_ENTITY Mechanism|nmod|activation Mechanism|nmod|expression expression|amod|END_ENTITY	Mechanism of estrogen activation of c-myc oncogene expression .
23291854	0	estrogen	97,105	c-myc	60,65	estrogen	c-myc	MESH:D004967	4609	Chemical	Gene	protection|compound|START_ENTITY mediates|dobj|protection mediates|nsubj|Regulation Regulation|nmod|NBS1 NBS1|nmod|END_ENTITY	Regulation of the Nijmegen_breakage_syndrome 1 gene NBS1 by c-myc , p53 and coactivators mediates estrogen protection from DNA damage in breast_cancer cells .
3045126	0	estrogen	59,67	c-myc	30,35	estrogen	c-myc	MESH:D004967	4609	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Transcriptional regulation of c-myc oncogene expression by estrogen in hormone-responsive human breast_cancer cells .
3337730	0	estrogen	49,57	c-myc	19,24	estrogen	c-myc	MESH:D004967	420332(Tax:9031)	Chemical	Gene	c-fos|nmod|START_ENTITY induced|nsubj|c-fos induced|nmod|regulation regulation|nmod|END_ENTITY	Down regulation of c-myc , c-fos and erb-B during estrogen induced proliferation_of_the_chick_oviduct .
8187952	0	estrogen	54,62	c-myc	30,35	estrogen	c-myc	MESH:D004967	4609	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|proto-oncogene proto-oncogene|amod|END_ENTITY	Transcriptional activation of c-myc proto-oncogene by estrogen in human ovarian_cancer cells .
16611827	0	estrogen	17,25	cAMP_response_element-binding_protein	51,88	estrogen	cAMP response element-binding protein	MESH:D004967	12912(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Estrogen induces estrogen receptor alpha-dependent cAMP_response_element-binding_protein phosphorylation via mitogen activated protein kinase pathway in basal forebrain cholinergic neurons in vivo .
25206716	0	estrogen	26,34	calbindin-D28K	8,22	estrogen	calbindin-D28K	MESH:D004967	12307(Tax:10090)	Chemical	Gene	treatment|compound|START_ENTITY END_ENTITY|nmod|treatment	Role of calbindin-D28K in estrogen treatment for Parkinson 's _ disease .
7776978	0	estrogen	14,22	calbindin-D28k	67,81	estrogen	calbindin-D28k	MESH:D004967	12307(Tax:10090)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|dep|region region|nmod|gene gene|amod|END_ENTITY	Regulation by estrogen through the 5 ' - flanking region of the mouse calbindin-D28k gene .
17365578	0	estrogen	46,54	calbindin-D9k	21,34	estrogen	calbindin-D9k	MESH:D004967	24249(Tax:10116)	Chemical	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	Induction of uterine calbindin-D9k through an estrogen receptor-dependent pathway following single injection with xenobiotic agents in immature rats .
11606384	0	estrogen	58,66	catechol-O-methyltransferase	15,43	estrogen	catechol-O-methyltransferase	MESH:D004967	1312	Chemical	Gene	metabolite|amod|START_ENTITY effects|nmod|metabolite effects|nmod|inhibition inhibition|amod|END_ENTITY	The effects of catechol-O-methyltransferase inhibition on estrogen metabolite and oxidative DNA damage levels in estradiol-treated MCF-7 cells .
12571159	0	estrogen	79,87	catechol-O-methyltransferase	17,45	estrogen	catechol-O-methyltransferase	MESH:D004967	1312	Chemical	Gene	levels|compound|START_ENTITY polymorphism|nmod|levels codon|dobj|polymorphism codon|nsubj|Influence Influence|nmod|END_ENTITY	Influence of the catechol-O-methyltransferase -LRB- COMT -RRB- codon 158 polymorphism on estrogen levels in women .
16191465	0	estrogen	59,67	catechol-O-methyltransferase	12,40	estrogen	catechol-O-methyltransferase	MESH:D004967	1312	Chemical	Gene	exposure|compound|START_ENTITY duration|nmod|exposure gene|appos|duration gene|amod|END_ENTITY	Polymorphic catechol-O-methyltransferase gene , duration of estrogen exposure , and breast_cancer risk : a nested case-control study in Taiwan .
18473748	0	estrogen	108,116	catechol-O-methyltransferase	60,88	estrogen	catechol-O-methyltransferase	MESH:D004967	1312	Chemical	Gene	receptor|compound|START_ENTITY expression|nmod|receptor expression|amod|END_ENTITY	Estrogenic phenol and catechol metabolites of PCBs modulate catechol-O-methyltransferase expression via the estrogen receptor : potential contribution to cancer risk .
4065528	0	estrogen	11,19	catechol-O-methyltransferase	39,67	estrogen	catechol-O-methyltransferase	MESH:D004967	1312	Chemical	Gene	START_ENTITY|dobj|gariepinus gariepinus|compound|activity activity|amod|END_ENTITY	Aromatase , estrogen 2-hydroxylase , and catechol-O-methyltransferase activity in isolated , cultured gonadotropic cells of mature African catfish , Clarias gariepinus -LRB- Burchell -RRB- .
671023	0	estrogen	13,21	catechol-O-methyltransferase	52,80	estrogen	catechol-O-methyltransferase	MESH:D004967	1312	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	The catechol estrogen , 2-hydroxyestradiol , inhibits catechol-O-methyltransferase activity in neuroblastoma cells .
7426122	0	estrogen	120,128	catechol-O-methyltransferase	68,96	estrogen	catechol-O-methyltransferase	MESH:D004967	1312	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Comparative properties of the catechol_estrogens , I : methylation by catechol-O-methyltransferase and binding to cytosol estrogen receptors .
22336460	0	estrogen	32,40	caveolin-1	9,19	estrogen	caveolin-1	MESH:D004967	857	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	-LSB- Role of caveolin-1 on membrane estrogen receptor mediated proliferation of endothelial progenitor cells -RSB- .
11035987	0	estrogen	47,55	connexin43	28,38	estrogen	connexin43	MESH:D004967	2697	Chemical	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Comparing regulation of the connexin43 gene by estrogen in uterine_leiomyoma and pregnancy myometrium .
19523531	0	estrogen	19,27	connexin43	68,78	estrogen	connexin43	MESH:D004967	24392(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY interaction|nmod|receptor regulates|nsubj|interaction regulates|dobj|phosphorylation phosphorylation|amod|END_ENTITY	The interaction of estrogen receptor alpha and caveolin-3 regulates connexin43 phosphorylation in metabolic inhibition-treated rat cardiomyocytes .
17483497	0	estrogen	18,26	constitutive_androstane_receptor	55,87	estrogen	constitutive androstane receptor	MESH:D004967	12355(Tax:10090)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	The environmental estrogen , nonylphenol , activates the constitutive_androstane_receptor .
8912806	0	estrogen	81,89	cornifin_alpha	14,28	estrogen	cornifin alpha	MESH:D004967	6698	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of cornifin_alpha expression in the vaginal and uterine epithelium by estrogen and retinoic_acid .
8828472	0	estrogen	54,62	corticotropin-releasing_hormone	11,42	estrogen	corticotropin-releasing hormone	MESH:D004967	81648(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY Effects|nmod|production Effects|nmod|END_ENTITY	Effects of corticotropin-releasing_hormone on ovarian estrogen production in vitro .
1569966	0	estrogen	31,39	creatine_kinase_B	62,79	estrogen	creatine kinase B	MESH:D004967	24264(Tax:10116)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|gene gene|compound|END_ENTITY	Delineation of sites mediating estrogen regulation of the rat creatine_kinase_B gene .
11986316	0	estrogen	19,27	cyclin_D1	56,65	estrogen	cyclin D1	MESH:D004967	595	Chemical	Gene	receptors|compound|START_ENTITY receptors|nmod|expression expression|amod|END_ENTITY	Opposing action of estrogen receptors alpha and beta on cyclin_D1 gene expression .
16980581	0	estrogen	58,66	cyclin_D1	81,90	estrogen	cyclin D1	MESH:D004967	595	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|progression progression|compound|END_ENTITY	A cell-type-specific transcriptional network required for estrogen regulation of cyclin_D1 and cell cycle progression in breast_cancer .
17560576	0	estrogen	53,61	cyclin_D1	127,136	estrogen	cyclin D1	MESH:D004967	12443(Tax:10090)	Chemical	Gene	localization|compound|START_ENTITY localization|nmod|END_ENTITY	GSK-3beta mediates in the progesterone inhibition of estrogen induced cyclin_D2 nuclear localization and cell proliferation in cyclin_D1 - / - mouse uterine epithelium .
9039267	0	estrogen	30,38	cyclin_D1	51,60	estrogen	cyclin D1	MESH:D004967	595	Chemical	Gene	receptor|compound|START_ENTITY activation|nmod|receptor activation|nmod|END_ENTITY	CDK-independent activation of estrogen receptor by cyclin_D1 .
9683804	0	estrogen	86,94	cyclin_D1	53,62	estrogen	cyclin D1	MESH:D004967	595	Chemical	Gene	MCF-7|compound|START_ENTITY effects|nmod|MCF-7 effects|nmod|END_ENTITY	Differential effects of estradiol and its analogs on cyclin_D1 and CDK4 expression in estrogen receptor positive MCF-7 and estrogen receptor-transfected MCF-10AEwt5 cells .
9801809	0	estrogen	40,48	cyclin_D1	98,107	estrogen	cyclin D1	MESH:D004967	595	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Cooperative and differential effects of estrogen , prolactin , 22K and 20K human growth hormones on cyclin_D1 / PRAD1 gene expression in T-47D human breast_cancer cells .
11071120	0	estrogen	159,167	cyclooxygenase-2	17,33	estrogen	cyclooxygenase-2	MESH:D004967	5743	Chemical	Gene	affected|nsubj|START_ENTITY investigated|ccomp|affected mediated|parataxis|investigated mediated|nsubjpass|induction induction|nmod|cells cells|amod|END_ENTITY	The induction of cyclooxygenase-2 by 17beta-estradiol in endothelial cells is mediated through protein kinase C. OBJECTIVE AND DESIGN : We investigated whether estrogen affected COX isoform expressed in human umbilical vein endothelial cells -LRB- HUVEC -RRB- .
15136101	0	estrogen	43,51	cyclooxygenase-2	22,38	estrogen	cyclooxygenase-2	MESH:D004967	5743	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	Estrogen up-regulates cyclooxygenase-2 via estrogen receptor in human uterine microvascular endothelial cells .
15144225	0	estrogen	61,69	cyclooxygenase-2	87,103	estrogen	cyclooxygenase-2	MESH:D004967	5743	Chemical	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	Benzo -LSB- a -RSB- pyrene regulates osteoblast proliferation through an estrogen receptor-related cyclooxygenase-2 pathway .
23625281	0	estrogen	14,22	cyclooxygenase-2	41,57	estrogen	cyclooxygenase-2	MESH:D004967	5743	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Expression of estrogen receptors -LRB- a , b -RRB- , cyclooxygenase-2 and aromatase in normal endometrium and endometrioid cancer_of_uterus .
19087623	0	estrogen	12,20	cytochrome_C_oxidase	60,80	estrogen	cytochrome C oxidase	MESH:D004967	304024(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of estrogen on activity and subunits expression of cytochrome_C_oxidase in mitochondria from genioglossus of rats subjected to chronic intermittent hypoxia -RSB- .
3349056	0	estrogen	112,120	cytochrome_P-450	61,77	estrogen	cytochrome P-450	MESH:D004967	25251(Tax:10116)	Chemical	Gene	liver|nmod|START_ENTITY END_ENTITY|nmod|liver	Cytochrome P-450C-M / F , a new constitutive form of microsomal cytochrome_P-450 in male and female rat liver with estrogen 2 - and 16 alpha-hydroxylase activity .
17320290	0	estrogen	92,100	cytochrome_c_oxidase	65,85	estrogen	cytochrome c oxidase	MESH:D004967	304024(Tax:10116)	Chemical	Gene	manner|amod|START_ENTITY END_ENTITY|nmod|manner	Ethanol withdrawal posttranslationally decreases the activity of cytochrome_c_oxidase in an estrogen reversible manner .
8892654	0	estrogen	76,84	decay-accelerating_factor	6,31	estrogen	decay-accelerating factor	MESH:D004967	13136(Tax:10090)	Chemical	Gene	induction|nmod|START_ENTITY END_ENTITY|dep|induction	Mouse decay-accelerating_factor : selective and tissue-specific induction by estrogen of the gene encoding the glycosylphosphatidylinositol-anchored form .
14742696	0	estrogen	152,160	eNOS	124,128	estrogen	eNOS	MESH:D004967	4846	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Augmented endothelial_nitric_oxide_synthase -LRB- eNOS -RRB- protein expression in human pregnant myometrium : possible involvement of eNOS promoter activation by estrogen via both estrogen_receptor _ -LRB- ER -RRB- alpha and ERbeta .
14742696	0	estrogen	152,160	eNOS	45,49	estrogen	eNOS	MESH:D004967	4846	Chemical	Gene	activation|nmod|START_ENTITY involvement|nmod|activation endothelial_nitric_oxide_synthase|dep|involvement endothelial_nitric_oxide_synthase|dep|END_ENTITY	Augmented endothelial_nitric_oxide_synthase -LRB- eNOS -RRB- protein expression in human pregnant myometrium : possible involvement of eNOS promoter activation by estrogen via both estrogen_receptor _ -LRB- ER -RRB- alpha and ERbeta .
10323670	0	estrogen	57,65	endothelial_nitric_oxide_synthase	20,53	estrogen	endothelial nitric oxide synthase	MESH:D004967	4846	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Rapid activation of endothelial_nitric_oxide_synthase by estrogen .
10512927	0	estrogen	8,16	endothelial_nitric_oxide_synthase	47,80	estrogen	endothelial nitric oxide synthase	MESH:D004967	24600(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY increases|nsubj|treatment increases|dobj|levels levels|nmod|protein protein|amod|END_ENTITY	Chronic estrogen treatment increases levels of endothelial_nitric_oxide_synthase protein in rat cerebral microvessels .
11029403	0	estrogen	9,17	endothelial_nitric_oxide_synthase	48,81	estrogen	endothelial nitric oxide synthase	MESH:D004967	4846	Chemical	Gene	engagement|compound|START_ENTITY activates|nsubj|engagement activates|dobj|END_ENTITY	Membrane estrogen receptor engagement activates endothelial_nitric_oxide_synthase via the PI3-kinase-Akt pathway in human endothelial cells .
11159848	0	estrogen	60,68	endothelial_nitric_oxide_synthase	105,138	estrogen	endothelial nitric oxide synthase	MESH:D004967	18127(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|nmod|disruption disruption|nmod|END_ENTITY	Defective bone formation and anabolic response to exogenous estrogen in mice with targeted disruption of endothelial_nitric_oxide_synthase .
11589505	0	estrogen	123,131	endothelial_nitric_oxide_synthase	37,70	estrogen	endothelial nitric oxide synthase	MESH:D004967	4846	Chemical	Gene	system|compound|START_ENTITY induced|nmod|system mRNA|acl|induced mRNA|amod|END_ENTITY	Estrogen prevents destabilization of endothelial_nitric_oxide_synthase mRNA induced by tumor_necrosis_factor_alpha through estrogen receptor mediated system .
12053012	0	estrogen	57,65	endothelial_nitric_oxide_synthase	19,52	estrogen	endothelial nitric oxide synthase	MESH:D004967	24600(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY END_ENTITY|nmod|receptors	Estrogen increases endothelial_nitric_oxide_synthase via estrogen receptors in rat cerebral blood vessels : effect preserved after concurrent treatment with medroxyprogesterone_acetate or progesterone .
12715114	0	estrogen	10,18	endothelial_nitric_oxide_synthase	72,105	estrogen	endothelial nitric oxide synthase	MESH:D004967	287024(Tax:9913)	Chemical	Gene	receptor|compound|START_ENTITY mediates|nsubj|receptor mediates|dobj|activation activation|nmod|END_ENTITY	-LSB- Membrane estrogen receptor mediates the rapid nongenomic activation of endothelial_nitric_oxide_synthase by estrogen -RSB- .
12715114	0	estrogen	109,117	endothelial_nitric_oxide_synthase	72,105	estrogen	endothelial nitric oxide synthase	MESH:D004967	287024(Tax:9913)	Chemical	Gene	-RSB-|compound|START_ENTITY mediates|nmod|-RSB- mediates|dobj|activation activation|nmod|END_ENTITY	-LSB- Membrane estrogen receptor mediates the rapid nongenomic activation of endothelial_nitric_oxide_synthase by estrogen -RSB- .
14512434	0	estrogen	149,157	endothelial_nitric_oxide_synthase	112,145	estrogen	endothelial nitric oxide synthase	MESH:D004967	4846	Chemical	Gene	mediates|nmod|START_ENTITY mediates|dobj|activation activation|nmod|END_ENTITY	Membrane estrogen receptor-dependent extracellular signal-regulated kinase pathway mediates acute activation of endothelial_nitric_oxide_synthase by estrogen in uterine artery endothelial cells .
14512434	0	estrogen	9,17	endothelial_nitric_oxide_synthase	112,145	estrogen	endothelial nitric oxide synthase	MESH:D004967	4846	Chemical	Gene	kinase|compound|START_ENTITY mediates|nsubj|kinase mediates|dobj|activation activation|nmod|END_ENTITY	Membrane estrogen receptor-dependent extracellular signal-regulated kinase pathway mediates acute activation of endothelial_nitric_oxide_synthase by estrogen in uterine artery endothelial cells .
14742696	0	estrogen	152,160	endothelial_nitric_oxide_synthase	10,43	estrogen	endothelial nitric oxide synthase	MESH:D004967	4846	Chemical	Gene	activation|nmod|START_ENTITY involvement|nmod|activation END_ENTITY|dep|involvement	Augmented endothelial_nitric_oxide_synthase -LRB- eNOS -RRB- protein expression in human pregnant myometrium : possible involvement of eNOS promoter activation by estrogen via both estrogen_receptor _ -LRB- ER -RRB- alpha and ERbeta .
15375508	0	estrogen	62,70	endothelial_nitric_oxide_synthase	14,47	estrogen	endothelial nitric oxide synthase	MESH:D004967	4846	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of endothelial_nitric_oxide_synthase is induced by estrogen with glycogen synthase 3beta phosphorylation in MCF-7 cells .
11776188	0	estrogen	12,20	endothelin-1	45,57	estrogen	endothelin-1	MESH:D004967	100009270(Tax:9986)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|amod|END_ENTITY	-LSB- Effects of estrogen on serum lipids , plasma endothelin-1 , atherosclerosis in ovariectomized rabbits -RSB- .
9790900	0	estrogen	76,84	endothelin-1	20,32	estrogen	endothelin-1	MESH:D004967	281137(Tax:9913)	Chemical	Gene	receptor|compound|START_ENTITY cells|nmod|receptor attenuates|nmod|cells attenuates|dobj|production production|amod|END_ENTITY	Estrogen attenuates endothelin-1 production by bovine endothelial cells via estrogen receptor .
17062355	0	estrogen	62,70	epidermal_growth_factor	12,35	estrogen	epidermal growth factor	MESH:D004967	13645(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY Effects|nmod|expression Effects|nmod|END_ENTITY	-LSB- Effects of epidermal_growth_factor on cellular expression of estrogen and androgen_receptors in mouse prostate -RSB- .
24103125	0	estrogen	93,101	epidermal_growth_factor	9,32	estrogen	epidermal growth factor	MESH:D004967	13645(Tax:10090)	Chemical	Gene	conditions|amod|START_ENTITY endometriosis|nmod|conditions pathogenesis|nmod|endometriosis signaling|nmod|pathogenesis END_ENTITY|acl|signaling	-LSB- Role of epidermal_growth_factor signaling system in the pathogenesis of endometriosis under estrogen deprivation conditions -RSB- .
2784840	0	estrogen	65,73	epidermal_growth_factor	22,45	estrogen	epidermal growth factor	MESH:D004967	25313(Tax:10116)	Chemical	Gene	receptors|nmod|START_ENTITY receptors|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of uterine epidermal_growth_factor -LRB- EGF -RRB- receptors by estrogen in the mature rat and during the estrous cycle .
3497071	1	estrogen	133,141	epidermal_growth_factor	177,200	estrogen	epidermal growth factor	MESH:D004967	25313(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Inhibitor effect of estrogen on binding and mitogenic effect of epidermal_growth_factor .
8901633	0	estrogen	81,89	epidermal_growth_factor	144,167	estrogen	epidermal growth factor	MESH:D004967	13645(Tax:10090)	Chemical	Gene	mice|amod|START_ENTITY lack|nsubj|mice lack|nmod|END_ENTITY	Physiological coupling of growth factor and steroid receptor signaling pathways : estrogen receptor knockout mice lack estrogen-like response to epidermal_growth_factor .
2784313	0	estrogen	50,58	epidermal_growth_factor-receptor	14,46	estrogen	epidermal growth factor-receptor	MESH:D004967	1956	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of epidermal_growth_factor-receptor by estrogen and antiestrogen in the human breast_cancer cell line MCF-7 .
16202921	0	estrogen	12,20	epidermal_growth_factor_receptor	137,169	estrogen	epidermal growth factor receptor	MESH:D004967	1956	Chemical	Gene	agonism|compound|START_ENTITY Analysis|nmod|agonism Analysis|dep|role role|nmod|amphiregulin amphiregulin|compound|END_ENTITY	Analysis of estrogen agonism and antagonism of tamoxifen , raloxifene , and ICI182780 in endometrial_cancer cells : a putative role for the epidermal_growth_factor_receptor ligand amphiregulin .
18289622	0	estrogen	28,36	epidermal_growth_factor_receptor	110,142	estrogen	epidermal growth factor receptor	MESH:D004967	1956	Chemical	Gene	receptor|compound|START_ENTITY Association|nmod|receptor Association|nmod|END_ENTITY	Association of the membrane estrogen receptor , GPR30 , with breast_tumor metastasis and transactivation of the epidermal_growth_factor_receptor .
21111822	0	estrogen	159,167	epidermal_growth_factor_receptor	96,128	estrogen	epidermal growth factor receptor	MESH:D004967	24329(Tax:10116)	Chemical	Gene	binding|nmod|START_ENTITY receptors-a|amod|binding END_ENTITY|nmod|receptors-a	Genistein enhances relaxation of the spontaneously hypertensive rat aorta by transactivation of epidermal_growth_factor_receptor following binding to membrane estrogen receptors-a and activation of a G protein-coupled , endothelial nitric_oxide synthase-dependent pathway .
21349822	0	estrogen	61,69	epidermal_growth_factor_receptor	15,47	estrogen	epidermal growth factor receptor	MESH:D004967	378478(Tax:7955)	Chemical	Gene	inhibition|compound|START_ENTITY signaling|nmod|inhibition END_ENTITY|acl|signaling	Involvement of epidermal_growth_factor_receptor signaling in estrogen inhibition of oocyte maturation mediated through the G_protein-coupled_estrogen_receptor -LRB- Gper -RRB- in zebrafish -LRB- Danio_rerio -RRB- .
23374155	0	estrogen	41,49	epidermal_growth_factor_receptor	65,97	estrogen	epidermal growth factor receptor	MESH:D004967	1956	Chemical	Gene	receptors|compound|START_ENTITY receptors|nmod|END_ENTITY	Evaluation of the coordinated actions of estrogen receptors with epidermal_growth_factor_receptor and insulin-like_growth_factor_receptor in the expression of cell surface heparan sulfate proteoglycans and cell motility in breast_cancer cells .
8770893	0	estrogen	58,66	epidermal_growth_factor_receptor	22,54	estrogen	epidermal growth factor receptor	MESH:D004967	1956	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Bimodal regulation of epidermal_growth_factor_receptor by estrogen in breast_cancer cells .
9141535	0	estrogen	8,16	epidermal_growth_factor_receptor	31,63	estrogen	epidermal growth factor receptor	MESH:D004967	1956	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	In vivo estrogen regulation of epidermal_growth_factor_receptor in human endometrium .
16844660	0	estrogen	50,58	eralpha	74,81	estrogen	eralpha	MESH:D004967	24890(Tax:10116)	Chemical	Gene	receptoralpha|amod|START_ENTITY receptoralpha|appos|END_ENTITY	Comparative expression and distribution of c-fos , estrogen receptoralpha -LRB- eralpha -RRB- , and p38alpha in the uterus of rats , monkeys , and humans .
10827006	0	estrogen	42,50	erythropoietin	21,35	estrogen	erythropoietin	MESH:D004967	13856(Tax:10090)	Chemical	Gene	manner|amod|START_ENTITY END_ENTITY|nmod|manner	The oviduct produces erythropoietin in an estrogen - and oxygen-dependent manner .
10221773	2	estrogen	585,593	estrogen_receptor	343,360	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	treatment|compound|START_ENTITY followed|nmod|treatment cells|acl|followed transactivated|nmod|cells transactivated|nsubjpass|binds binds|nmod|END_ENTITY	This sequence binds to the estrogen_receptor when nucleoside_A is present at this site and reporter constructs containing human angiotensinogen gene promoter with nucleoside_A at -20 are transactivated on co-transfection of estrogen_receptor in HepG2 cells followed by estrogen treatment .
10601607	0	estrogen	101,109	estrogen_receptor	14,31	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	environments|compound|START_ENTITY Regulation|nmod|environments Regulation|nmod|END_ENTITY	Regulation of estrogen_receptor and epidermal_growth_factor_receptor by tamoxifen under high and low estrogen environments in MCF-7 cells grown in athymic mice .
10648810	0	estrogen	40,48	estrogen_receptor	95,112	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	element|compound|START_ENTITY adduct|nmod|element decreases|nsubj|adduct decreases|dobj|the the|nmod|END_ENTITY	A single d -LRB- GpG -RRB- cisplatin adduct on the estrogen response element decreases the binding of the estrogen_receptor .
10650938	0	estrogen	51,59	estrogen_receptor	4,21	estrogen	estrogen receptor	MESH:D004967	100136026(Tax:8022)	Chemical	Gene	dependencies|compound|START_ENTITY generated|nsubjpass|dependencies isoforms|advcl|generated isoforms|nsubj|END_ENTITY	Two estrogen_receptor -LRB- ER -RRB- isoforms with different estrogen dependencies are generated from the trout ER gene .
10806217	0	estrogen	9,17	estrogen_receptor	57,74	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	sensitivity|compound|START_ENTITY sensitivity|nmod|bone bone|acl|inhibiting inhibiting|xcomp|alpha alpha|nsubj|END_ENTITY	Impaired estrogen sensitivity in bone by inhibiting both estrogen_receptor alpha and beta pathways .
10955825	0	estrogen	88,96	estrogen_receptor	45,62	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	actions|compound|START_ENTITY END_ENTITY|dobj|actions	1alpha,25-Dihydroxyvitamin _ D3 down-regulates estrogen_receptor abundance and suppresses estrogen actions in MCF-7 human breast_cancer cells .
11077089	0	estrogen	48,56	estrogen_receptor	15,32	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	ability|compound|START_ENTITY devoid|nmod|ability form|xcomp|devoid form|nsubj|Evidence Evidence|nmod|END_ENTITY	Evidence of an estrogen_receptor form devoid of estrogen binding ability in MCF-7 cells .
11162886	0	estrogen	137,145	estrogen_receptor	94,111	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	levels|compound|START_ENTITY independent|nmod|levels elevates|xcomp|independent elevates|advcl|reversing reversing|dobj|potentiation potentiation|nmod|activity activity|compound|END_ENTITY	TCDD elevates erbB2 expression and signaling in T47D cells by reversing serum potentiation of estrogen_receptor activity , independent of estrogen levels and enhanced ER down-regulation .
11243092	0	estrogen	159,167	estrogen_receptor	64,81	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	decreased|nmod|START_ENTITY decreased|nsubj|cells cells|acl|transfected transfected|nmod|exhibit exhibit|compound|END_ENTITY	Estrogen_receptor-negative breast_cancer cells transfected with estrogen_receptor exhibit decreased tumour progression and sensitivity to growth inhibition by estrogen .
11435612	0	estrogen	69,77	estrogen_receptor	25,42	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	elements|compound|START_ENTITY conformation|nmod|elements conformation|nsubj|modulation modulation|nmod|END_ENTITY	Allosteric modulation of estrogen_receptor conformation by different estrogen response elements .
11836633	0	estrogen	47,55	estrogen_receptor	8,25	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	induced|compound|START_ENTITY regulation|nmod|induced END_ENTITY|nmod|regulation	Role of estrogen_receptor in the regulation of estrogen induced amino_acid transport of System A in breast_cancer and other receptor positive tumor cells .
11950274	0	estrogen	47,55	estrogen_receptor	4,21	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	neuroprotection|compound|START_ENTITY essential|nmod|neuroprotection essential|nsubj|END_ENTITY	The estrogen_receptor is not essential for all estrogen neuroprotection : new evidence from a new analog .
12237165	0	estrogen	125,133	estrogen_receptor	14,31	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	regulation|nmod|START_ENTITY Expression|dep|regulation Expression|nmod|subtypes subtypes|compound|END_ENTITY	Expression of estrogen_receptor subtypes and neuronal nitric_oxide synthase in neutrophils from women and men : regulation by estrogen .
12488344	0	estrogen	104,112	estrogen_receptor	10,27	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	regulate|nmod|START_ENTITY modulators|xcomp|regulate modulators|nsubj|END_ENTITY	Selective estrogen_receptor modulators regulate phasic activation of hippocampal CA1 pyramidal cells by estrogen .
1358436	0	estrogen	55,63	estrogen_receptor	75,92	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	START_ENTITY|acl|stimulated stimulated|dobj|END_ENTITY	Transcriptional repression of the neu protooncogene by estrogen stimulated estrogen_receptor .
14617632	0	estrogen	18,26	estrogen_receptor	93,110	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	sequence|amod|START_ENTITY Interplay|nmod|sequence controls|nsubj|Interplay controls|nmod|vivo vivo|nmod|END_ENTITY	Interplay between estrogen response element sequence and ligands controls in vivo binding of estrogen_receptor to regulated genes .
15171723	0	estrogen	102,110	estrogen_receptor	17,34	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	independence|amod|START_ENTITY lacking|nmod|independence variant|xcomp|lacking variant|nsubj|Expression Expression|nmod|END_ENTITY	Expression of an estrogen_receptor variant lacking exon 3 in derivatives of MCF-7 cells with acquired estrogen independence or tamoxifen resistance .
15833885	0	estrogen	18,26	estrogen_receptor	49,66	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	START_ENTITY|acl|signaling signaling|advcl|altering altering|dobj|expression expression|compound|END_ENTITY	Selenium disrupts estrogen signaling by altering estrogen_receptor expression and ligand binding in human breast_cancer cells .
16279785	0	estrogen	120,128	estrogen_receptor	28,45	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	antagonists|compound|START_ENTITY Synthesis|dep|antagonists Synthesis|nmod|ligands ligands|compound|END_ENTITY	Synthesis and evaluation of estrogen_receptor ligands with bridged oxabicyclic cores containing a diarylethylene motif : estrogen antagonists of unusual structure .
1632645	0	estrogen	15,23	estrogen_receptor	56,73	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|nmod|END_ENTITY	The binding of estrogen and estrogen antagonists to the estrogen_receptor .
16621526	0	estrogen	127,135	estrogen_receptor	4,21	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	sensitivity|compound|START_ENTITY markers|nmod|sensitivity tamoxifen|nmod|markers breast_cancer|nmod|tamoxifen Are|nmod|breast_cancer Are|nsubj|content content|compound|END_ENTITY	Are estrogen_receptor content in breast_cancer and effects of tamoxifen on sex_hormone-binding_globulin markers for individual estrogen sensitivity ?
1682189	0	estrogen	87,95	estrogen_receptor	31,48	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	effect|nmod|START_ENTITY expression|dep|effect expression|nmod|END_ENTITY	Stable expression of the human estrogen_receptor in HeLa cells by infection : effect of estrogen on cell proliferation and c-myc expression .
17261769	0	estrogen	43,51	estrogen_receptor	66,83	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	modulators|compound|START_ENTITY modulators|compound|END_ENTITY	Monocyte-macrophage system as a target for estrogen and selective estrogen_receptor modulators .
1756269	0	estrogen	79,87	estrogen_receptor	23,40	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	responsiveness|compound|START_ENTITY relation|nmod|responsiveness forms|dep|relation forms|nmod|END_ENTITY	65 and 47 kDa forms of estrogen_receptor in human breast_cancer : relation with estrogen responsiveness .
17635941	0	estrogen	112,120	estrogen_receptor	52,69	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	expression|amod|START_ENTITY abrogates|dobj|expression abrogates|nsubj|delivery delivery|nmod|gene gene|compound|END_ENTITY	Adenovirus-mediated delivery of a dominant-negative estrogen_receptor gene in uterine leiomyoma cells abrogates estrogen - and progesterone-regulated gene expression .
17678875	0	estrogen	108,116	estrogen_receptor	33,50	estrogen	estrogen receptor	MESH:D004967	100533442	Chemical	Gene	binding|nsubj|START_ENTITY prevent|xcomp|binding evidence|acl:relcl|prevent Analysis|dep|evidence Analysis|nmod|models models|nmod|END_ENTITY	Analysis of 3D models of octopus estrogen_receptor with estradiol : evidence for steric clashes that prevent estrogen binding .
17686309	0	estrogen	50,58	estrogen_receptor	72,89	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	lines|compound|START_ENTITY lines|amod|dependent dependent|nmod|breast_cancer breast_cancer|amod|END_ENTITY	-LSB- Effect of PC-cell_derived_growth_factor shRNA on estrogen dependent of estrogen_receptor negative breast_cancer cell lines -RSB- .
18026938	0	estrogen	17,25	estrogen_receptor	57,74	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	presence|compound|START_ENTITY Determination|nmod|presence Determination|acl|using using|dobj|dimerization dimerization|compound|END_ENTITY	Determination of estrogen presence in water by SPR using estrogen_receptor dimerization .
18079323	0	estrogen	22,30	estrogen_receptor	108,125	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	synthesis|compound|START_ENTITY glutamic_acid|nmod|synthesis Modulation|acl|glutamic_acid Modulation|dep|autocrine autocrine|compound|END_ENTITY	Modulation of in situ estrogen synthesis by proline - , glutamic_acid - , and leucine-rich protein-1 : potential estrogen_receptor autocrine signaling loop in breast_cancer cells .
19212635	0	estrogen	124,132	estrogen_receptor	42,59	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	levels|compound|START_ENTITY Effects|nmod|levels Effects|nmod|CH4893237 CH4893237|appos|downregulator downregulator|compound|END_ENTITY	Effects of CH4893237 , a new orally active estrogen_receptor downregulator , on breast_cancer xenograft models with low serum estrogen levels .
193182	0	estrogen	77,85	estrogen_receptor	41,58	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	absence|nmod|START_ENTITY END_ENTITY|nmod|absence	Human breast_cancer : biologically active estrogen_receptor in the absence of estrogen ?
2011412	0	estrogen	32,40	estrogen_receptor	101,118	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	agonists|compound|START_ENTITY analysis|nmod|agonists analysis|dep|relation relation|nmod|activation activation|nmod|END_ENTITY	Equilibrium binding analysis of estrogen agonists and antagonists : relation to the activation of the estrogen_receptor .
20197310	0	estrogen	78,86	estrogen_receptor	15,32	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	signaling|compound|START_ENTITY Involvement|nmod|signaling Involvement|nmod|variant variant|compound|END_ENTITY	Involvement of estrogen_receptor variant ER-alpha36 , not GPR30 , in nongenomic estrogen signaling .
2119495	0	estrogen	21,29	estrogen_receptor	95,112	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	element|compound|START_ENTITY Identification|nmod|element upstream|nsubj|Identification upstream|nmod|gene gene|acl:relcl|binds binds|dobj|END_ENTITY	Identification of an estrogen response element upstream of the human c-fos gene that binds the estrogen_receptor and the AP-1 transcription factor .
21289296	0	estrogen	17,25	estrogen_receptor	78,95	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	derivative|compound|START_ENTITY breast_cancer|nsubj|derivative breast_cancer|xcomp|independent independent|nmod|expression expression|compound|END_ENTITY	A lipid-modified estrogen derivative that treats breast_cancer independent of estrogen_receptor expression through simultaneous induction of autophagy and apoptosis .
2152373	0	estrogen	50,58	estrogen_receptor	93,110	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	agonists|compound|START_ENTITY interaction|nmod|agonists significance|nmod|interaction significance|nmod|END_ENTITY	The biological significance of the interaction of estrogen agonists and antagonists with the estrogen_receptor .
2161254	2	estrogen	122,130	estrogen_receptor	155,172	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Requirement of both kinase and phosphatase activities for conferring estrogen binding activity to the estrogen_receptor .
21683083	0	estrogen	107,115	estrogen_receptor	83,100	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	environment|compound|START_ENTITY END_ENTITY|nmod|environment	HOXC6 Is transcriptionally regulated via coordination of MLL histone methylase and estrogen_receptor in an estrogen environment .
2282976	0	estrogen	152,160	estrogen_receptor	14,31	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	ribonucleic_acid|nmod|START_ENTITY ribonucleic_acid|nsubj|Expression Expression|nmod|END_ENTITY	Expression of estrogen_receptor and its messenger ribonucleic_acid in the MCF-7 cell line : multiparametric analysis of its processing and regulation by estrogen .
23062772	0	estrogen	71,79	estrogen_receptor	4,21	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	deprivation|compound|START_ENTITY due|nmod|deprivation tissues|amod|due overexpression|nmod|tissues overexpression|compound|END_ENTITY	Can estrogen_receptor overexpression in normal tissues due to previous estrogen deprivation explain the fulvestrant efficacy in breast_cancer therapy ?
2328826	0	estrogen	118,126	estrogen_receptor	41,58	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	elements|amod|START_ENTITY containing|dobj|elements promoters|acl|containing stimulate|nmod|promoters different|dep|stimulate different|nmod|END_ENTITY	Transcription factors different from the estrogen_receptor stimulate in vitro transcription from promoters containing estrogen response elements .
23312071	0	estrogen	22,30	estrogen_receptor	86,103	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	ligands|compound|START_ENTITY ligands|dep|application application|nmod|concept concept|nmod|END_ENTITY	Nonsteroidal bivalent estrogen ligands : an application of the bivalent concept to the estrogen_receptor .
23339407	0	estrogen	14,22	estrogen_receptor	89,106	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	responses|compound|START_ENTITY modifies|dobj|responses modifies|advcl|influencing influencing|dobj|expression expression|nmod|END_ENTITY	RhoB modifies estrogen responses in breast_cancer cells by influencing expression of the estrogen_receptor .
2350335	0	estrogen	74,82	estrogen_receptor	27,44	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	responsiveness|compound|START_ENTITY induces|dobj|responsiveness induces|nsubj|transfection transfection|nmod|cDNA cDNA|compound|END_ENTITY	Stable transfection of the estrogen_receptor cDNA into Hela cells induces estrogen responsiveness of endogenous cathepsin_D gene but not of cell growth .
24280273	0	estrogen	50,58	estrogen_receptor	32,49	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	interaction|amod|START_ENTITY Impact|dep|interaction Impact|nmod|END_ENTITY	Impact of biochemical design on estrogen_receptor / estrogen response element interaction by surface plasmon resonance technology .
2459605	0	estrogen	92,100	estrogen_receptor	10,27	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	levels|nmod|START_ENTITY associated|nmod|levels associated|nsubjpass|acid acid|compound|END_ENTITY	A variant estrogen_receptor messenger ribonucleic acid is associated with reduced levels of estrogen binding in human mammary_tumors .
24823458	0	estrogen	7,15	estrogen_receptor	24,41	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	levels|compound|START_ENTITY levels|appos|variation variation|compound|END_ENTITY	Plasma estrogen levels , estrogen_receptor gene variation , and ischemic_arterial_disease in postmenopausal women : the three-city prospective cohort study .
26052034	0	estrogen	95,103	estrogen_receptor	67,84	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	therapy|amod|START_ENTITY END_ENTITY|nmod|therapy	The molecular , cellular and clinical consequences of targeting the estrogen_receptor following estrogen deprivation therapy .
2755123	0	estrogen	28,36	estrogen_receptor	97,114	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	Role|nmod|START_ENTITY sulfotransferase|nsubj|Role sulfotransferase|nmod|downregulation downregulation|nmod|END_ENTITY	Role of porcine endometrial estrogen sulfotransferase in progesterone mediated downregulation of estrogen_receptor .
2793867	0	estrogen	87,95	estrogen_receptor	174,191	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	site|nmod|START_ENTITY 530|nmod|site 530|nmod|END_ENTITY	Identification of cysteine 530 as the covalent attachment site of an affinity-labeling estrogen -LRB- ketononestrol_aziridine -RRB- and antiestrogen -LRB- tamoxifen_aziridine -RRB- in the human estrogen_receptor .
2965035	0	estrogen	12,20	estrogen_receptor	61,78	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	agents|amod|START_ENTITY agents|nmod|synthesis synthesis|compound|END_ENTITY	-LSB- Effects of estrogen and endocrine therapeutic agents on the estrogen_receptor , progesterone_receptor and DNA synthesis in MCF-7 human breast_cancer cells using the whole cell uptake method -RSB- .
3022052	0	estrogen	39,47	estrogen_receptor	128,145	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	Peroxidase-antiperoxidase|nmod|START_ENTITY Peroxidase-antiperoxidase|dep|existence existence|nmod|END_ENTITY	Peroxidase-antiperoxidase staining for estrogen and progesterone in scirrhous type of gastric_cancer : possible existence of the estrogen_receptor .
3242819	0	estrogen	100,108	estrogen_receptor	20,37	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|gene gene|compound|END_ENTITY	Regulation of human estrogen_receptor gene , epidermal_growth_factor_receptor gene , and oncogenes by estrogen and antiestrogen in MCF-7 breast_cancer cells .
3454123	0	estrogen	27,35	estrogen_receptor	100,117	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	action|compound|START_ENTITY Progesterone-modulation|nmod|action Progesterone-modulation|dep|regulation regulation|nmod|sites sites|nmod|END_ENTITY	Progesterone-modulation of estrogen action : rapid down regulation of nuclear acceptor sites for the estrogen_receptor .
6692388	0	estrogen	20,28	estrogen_receptor	147,164	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	Differences|nmod|START_ENTITY raised|nsubj|Differences raised|nmod|END_ENTITY	Differences between estrogen - and antiestrogen-estrogen_receptor complexes from human breast_tumors identified with an antibody raised against the estrogen_receptor .
7577701	0	estrogen	21,29	estrogen_receptor	70,87	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	structure|amod|START_ENTITY structure|nmod|END_ENTITY	Relationship between estrogen structure and conformational changes in estrogen_receptor / DNA complexes .
8033827	0	estrogen	67,75	estrogen_receptor	35,52	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Cell cycle-dependent expression of estrogen_receptor and effect of estrogen on proliferation of synchronized human osteoblast-like osteosarcoma cells .
8048961	0	estrogen	86,94	estrogen_receptor	26,43	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	element|compound|START_ENTITY enhanced|nmod|element exhibiting|dobj|enhanced exhibiting|nsubj|END_ENTITY	Antiestrogens activate an estrogen_receptor mutant exhibiting enhanced binding to the estrogen response element .
8530431	0	estrogen	93,101	estrogen_receptor	45,62	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	response|compound|START_ENTITY binding|nmod|response element|amod|binding required|nmod|element required|nsubjpass|Phosphorylation Phosphorylation|nmod|537 537|nmod|END_ENTITY	Phosphorylation of tyrosine 537 on the human estrogen_receptor is required for binding to an estrogen response element .
8645623	0	estrogen	71,79	estrogen_receptor	45,62	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	element|compound|START_ENTITY analysis|nmod|element analysis|nmod|interaction interaction|nmod|END_ENTITY	Kinetic analysis of the interaction of human estrogen_receptor with an estrogen response element .
8702724	0	estrogen	104,112	estrogen_receptor	73,90	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of amino_acids in the hormone binding domain of the human estrogen_receptor important in estrogen binding .
8738832	0	estrogen	162,170	estrogen_receptor	14,31	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	DNA|amod|START_ENTITY recognition|nmod|DNA differences|nmod|recognition stabilize|dobj|differences stabilize|nsubj|antibodies antibodies|compound|END_ENTITY	Site-directed estrogen_receptor antibodies stabilize 4-hydroxytamoxifen ligand , but not estradiol , and indicate ligand-specific differences in the recognition of estrogen response element DNA in vitro .
8809185	0	estrogen	60,68	estrogen_receptor	22,39	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	elements|compound|START_ENTITY binding|nmod|elements analysis|amod|binding analysis|nmod|END_ENTITY	Footprint analysis of estrogen_receptor binding to adjacent estrogen response elements .
8862493	0	estrogen	104,112	estrogen_receptor	49,66	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	receptors|compound|START_ENTITY detection|nmod|receptors detection|compound|END_ENTITY	In situ hybridization study of messenger RNA for estrogen_receptor and immunohistochemical detection of estrogen and progesterone receptors in the human ovary .
8885989	0	estrogen	25,33	estrogen_receptor	58,75	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	capacity|compound|START_ENTITY capacity|nmod|END_ENTITY	Calmodulin decreases the estrogen binding capacity of the estrogen_receptor .
8961262	0	estrogen	102,110	estrogen_receptor	27,44	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	action|compound|START_ENTITY inhibitor|nmod|action type|nmod|inhibitor type|nsubj|mutant mutant|compound|END_ENTITY	A transcriptionally active estrogen_receptor mutant is a novel type of dominant negative inhibitor of estrogen action .
9045869	0	estrogen	158,166	estrogen_receptor	121,138	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	response|compound|START_ENTITY binding|nmod|response element|amod|binding END_ENTITY|nmod|element	Vitamin_D and gonadal steroid-resistant New World primate cells express an intracellular protein which competes with the estrogen_receptor for binding to the estrogen response element .
9099898	0	estrogen	79,87	estrogen_receptor	123,140	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	responsive|amod|START_ENTITY independent|amod|responsive independent|nmod|END_ENTITY	Retinoid_X_receptor and peroxisome_proliferator-activated_receptor activate an estrogen responsive gene independent of the estrogen_receptor .
9346945	0	estrogen	72,80	estrogen_receptor	15,32	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	binding|xcomp|START_ENTITY enhances|xcomp|binding enhances|csubj|Dimerizing Dimerizing|dobj|domain domain|amod|END_ENTITY	Dimerizing the estrogen_receptor DNA binding domain enhances binding to estrogen response elements .
9496644	0	estrogen	76,84	estrogen_receptor	12,29	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	metabolism|compound|START_ENTITY Role|nmod|metabolism Role|nmod|END_ENTITY	Role of the estrogen_receptor in the action of organochlorine pesticides on estrogen metabolism in human breast_cancer cell lines .
9792632	0	estrogen	55,63	estrogen_receptor	26,43	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	binding|xcomp|START_ENTITY binding|nsubj|requirements requirements|nmod|END_ENTITY	Sequence requirements for estrogen_receptor binding to estrogen response elements .
9806352	0	estrogen	70,78	estrogen_receptor	35,52	estrogen	estrogen receptor	MESH:D004967	2099	Chemical	Gene	elements|amod|START_ENTITY ligands|nmod|elements ligands|nmod|interaction interaction|compound|END_ENTITY	Comparison of tamoxifen ligands on estrogen_receptor interaction with estrogen response elements .
23074235	0	estrogen	140,148	estrogen_receptor-a	10,29	estrogen	estrogen receptor-a	MESH:D004967	2099	Chemical	Gene	modulators|compound|START_ENTITY role|nmod|modulators reduces|parataxis|role reduces|nsubj|END_ENTITY	Targeting estrogen_receptor-a reduces adrenocortical_cancer -LRB- ACC -RRB- cell growth in vitro and in vivo : potential therapeutic role of selective estrogen receptor modulators -LRB- SERMs -RRB- for ACC treatment .
23225083	0	estrogen	107,115	estrogen_receptor-a	44,63	estrogen	estrogen receptor-a	MESH:D004967	13982(Tax:10090)	Chemical	Gene	modulators|amod|START_ENTITY effects|nmod|modulators END_ENTITY|nmod|effects	The role of activation functions 1 and 2 of estrogen_receptor-a for the effects of estradiol and selective estrogen receptor modulators in male mice .
23319543	0	estrogen	213,221	estrogen_receptor-a	186,205	estrogen	estrogen receptor-a	MESH:D004967	2099	Chemical	Gene	receptor-b|compound|START_ENTITY END_ENTITY|nmod|receptor-b	Estradiol-17b and its cytochrome P450 - and catechol-O-methyltransferase-derived metabolites selectively stimulate production of prostacyclin in uterine artery endothelial cells : role of estrogen_receptor-a versus estrogen receptor-b .
23433206	0	estrogen	126,134	estrogen_receptor-a	66,85	estrogen	estrogen receptor-a	MESH:D004967	13982(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|amod|END_ENTITY	-LSB- Effects of carbon_disulfide exposure during peri-implantation on estrogen_receptor-a expression in uterus and serum level of estrogen in pregnant mice -RSB- .
24366551	0	estrogen	93,101	estrogen_receptor-a	33,52	estrogen	estrogen receptor-a	MESH:D004967	2099	Chemical	Gene	cells|amod|START_ENTITY suppressing|nmod|cells END_ENTITY|advcl|suppressing	Protein_kinase_C-a downregulates estrogen_receptor-a by suppressing c-Jun phosphorylation in estrogen receptor-positive breast_cancer cells .
10551786	0	estrogen	89,97	estrogen_receptor-alpha	38,61	estrogen	estrogen receptor-alpha	MESH:D004967	2099	Chemical	Gene	usage|nmod|START_ENTITY usage|nmod|gene gene|amod|END_ENTITY	Selective promoter usage of the human estrogen_receptor-alpha gene and its regulation by estrogen .
11150243	0	estrogen	85,93	estrogen_receptor-alpha	41,64	estrogen	estrogen receptor-alpha	MESH:D004967	13982(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY mediates|dobj|effects mediates|nsubj|END_ENTITY	Evidence that epithelial and mesenchymal estrogen_receptor-alpha mediates effects of estrogen on prostatic epithelium .
11641386	0	estrogen	80,88	estrogen_receptor-alpha	105,128	estrogen	estrogen receptor-alpha	MESH:D004967	13982(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|acl|lacking lacking|dobj|END_ENTITY	Selected contribution : cerebrovascular nos and cyclooxygenase are unaffected by estrogen in mice lacking estrogen_receptor-alpha .
11751931	0	estrogen	136,144	estrogen_receptor-alpha	15,38	estrogen	estrogen receptor-alpha	MESH:D004967	13982(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Requirement Requirement|nmod|END_ENTITY	Requirement of estrogen_receptor-alpha in insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- - induced uterine responses and in vivo evidence for IGF-1 / estrogen receptor cross-talk .
12505546	0	estrogen	30,38	estrogen_receptor-alpha	76,99	estrogen	estrogen receptor-alpha	MESH:D004967	13982(Tax:10090)	Chemical	Gene	bisphenol_A|compound|START_ENTITY Exposure|nmod|bisphenol_A modulated|nsubj|Exposure modulated|dobj|immunoreactivity immunoreactivity|amod|END_ENTITY	Exposure to the environmental estrogen bisphenol_A differentially modulated estrogen_receptor-alpha and - beta immunoreactivity and mRNA in male mouse testis .
12593897	0	estrogen	169,177	estrogen_receptor-alpha	14,37	estrogen	estrogen receptor-alpha	MESH:D004967	13982(Tax:10090)	Chemical	Gene	hormones|compound|START_ENTITY treatment|nmod|hormones mice|nmod|treatment uterus|nmod|mice kinase-3beta|nmod|uterus synthase|xcomp|kinase-3beta synthase|nsubj|Expression Expression|nmod|receptor receptor|amod|END_ENTITY	Expression of estrogen_receptor-alpha , glucocorticoid receptor , beta-catenin and glycogen synthase kinase-3beta in the uterus of mice following long-term treatment with estrogen and glucocorticoid hormones .
12642782	0	estrogen	55,63	estrogen_receptor-alpha	8,31	estrogen	estrogen receptor-alpha	MESH:D004967	2099	Chemical	Gene	action|compound|START_ENTITY pharmacogenetics|nmod|action Role|nmod|pharmacogenetics Role|nmod|END_ENTITY	Role of estrogen_receptor-alpha in pharmacogenetics of estrogen action .
14718389	0	estrogen	163,171	estrogen_receptor-alpha	13,36	estrogen	estrogen receptor-alpha	MESH:D004967	2099	Chemical	Gene	absence|nmod|START_ENTITY promote|nmod|absence promote|nsubj|Increases Increases|nmod|concentration concentration|amod|END_ENTITY	Increases in estrogen_receptor-alpha concentration in breast_cancer cells promote serine 118/104/106-independent AF-1 transactivation and growth in the absence of estrogen .
15647773	0	estrogen	11,19	estrogen_receptor-alpha	85,108	estrogen	estrogen receptor-alpha	MESH:D004967	2099	Chemical	Gene	responses|compound|START_ENTITY responses|acl|using using|advcl|encoding encoding|dobj|END_ENTITY	Inhibiting estrogen responses in breast_cancer cells using a fusion protein encoding estrogen_receptor-alpha and the transcriptional repressor PLZF .
15963345	0	estrogen	77,85	estrogen_receptor-alpha	114,137	estrogen	estrogen receptor-alpha	MESH:D004967	2099	Chemical	Gene	region|compound|START_ENTITY region|nmod|END_ENTITY	Arsenite binding to synthetic peptides based on the Zn finger region and the estrogen binding region of the human estrogen_receptor-alpha .
16840538	0	estrogen	9,17	estrogen_receptor-alpha	82,105	estrogen	estrogen receptor-alpha	MESH:D004967	2099	Chemical	Gene	antagonist|compound|START_ENTITY antagonist|acl:relcl|promotes promotes|dobj|interaction interaction|nmod|END_ENTITY	The pure estrogen receptor antagonist ICI_182 ,780 promotes a novel interaction of estrogen_receptor-alpha with the 3 ' ,5 ' - cyclic_adenosine_monophosphate response element-binding protein-binding protein/p300 coactivators .
17045112	0	estrogen	39,47	estrogen_receptor-alpha	14,37	estrogen	estrogen receptor-alpha	MESH:D004967	2099	Chemical	Gene	receptor-beta|amod|START_ENTITY receptor-beta|amod|END_ENTITY	Expression of estrogen_receptor-alpha , estrogen receptor-beta and placental endothelial and inducible_NO_synthase in intrauterine growth-restricted and normal placentals .
17415682	0	estrogen	136,144	estrogen_receptor-alpha	41,64	estrogen	estrogen receptor-alpha	MESH:D004967	2099	Chemical	Gene	treatment|compound|START_ENTITY cells|nmod|treatment cells|amod|END_ENTITY	A novel gene STYK1/NOK is upregulated in estrogen_receptor-alpha negative estrogen receptor-beta positive breast_cancer cells following estrogen treatment .
17415682	0	estrogen	74,82	estrogen_receptor-alpha	41,64	estrogen	estrogen receptor-alpha	MESH:D004967	2099	Chemical	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	A novel gene STYK1/NOK is upregulated in estrogen_receptor-alpha negative estrogen receptor-beta positive breast_cancer cells following estrogen treatment .
17631492	0	estrogen	92,100	estrogen_receptor-alpha	49,72	estrogen	estrogen receptor-alpha	MESH:D004967	2099	Chemical	Gene	XCT790|amod|START_ENTITY degradation|nmod|XCT790 degradation|amod|END_ENTITY	Potentiation of ICI182 ,780 -LRB- Fulvestrant -RRB- - induced estrogen_receptor-alpha degradation by the estrogen receptor-related receptor-alpha inverse agonist XCT790 .
18096994	0	estrogen	82,90	estrogen_receptor-alpha	22,45	estrogen	estrogen receptor-alpha	MESH:D004967	2099	Chemical	Gene	presence|nmod|START_ENTITY variation|nmod|presence variation|nmod|turnover turnover|amod|END_ENTITY	Temporal variation in estrogen_receptor-alpha protein turnover in the presence of estrogen .
19279395	0	estrogen	12,20	estrogen_receptor-alpha	40,63	estrogen	estrogen receptor-alpha	MESH:D004967	443228(Tax:9940)	Chemical	Gene	action|compound|START_ENTITY Blockade|nmod|action upregulates|nsubj|Blockade upregulates|dobj|mRNA mRNA|amod|END_ENTITY	Blockade of estrogen action upregulates estrogen_receptor-alpha mRNA in the fetal brain .
19331827	0	estrogen	91,99	estrogen_receptor-alpha	135,158	estrogen	estrogen receptor-alpha	MESH:D004967	2099	Chemical	Gene	interaction|compound|START_ENTITY interaction|nmod|END_ENTITY	Estrogen inhibits RANKL-stimulated osteoclastic differentiation of human monocytes through estrogen and RANKL-regulated interaction of estrogen_receptor-alpha with BCAR1 and Traf6 .
19574448	0	estrogen	88,96	estrogen_receptor-alpha	15,38	estrogen	estrogen receptor-alpha	MESH:D004967	13982(Tax:10090)	Chemical	Gene	essential|xcomp|START_ENTITY essential|nsubj|binding binding|nmod|END_ENTITY	DNA binding by estrogen_receptor-alpha is essential for the transcriptional response to estrogen in the liver and the uterus .
21975535	0	estrogen	55,63	estrogen_receptor-alpha	79,102	estrogen	estrogen receptor-alpha	MESH:D004967	13982(Tax:10090)	Chemical	Gene	action|compound|START_ENTITY independent|nmod|action independent|nmod|END_ENTITY	Immune cell-mediated neuroprotection is independent of estrogen action through estrogen_receptor-alpha .
23579816	0	estrogen	19,27	estrogen_receptor-alpha	186,209	estrogen	estrogen receptor-alpha	MESH:D004967	2099	Chemical	Gene	ER-b1|compound|START_ENTITY Expression|nmod|ER-b1 predictive|nsubjpass|Expression predictive|nmod|patients patients|nmod|END_ENTITY	Expression of both estrogen receptor-beta 1 -LRB- ER-b1 -RRB- and its co-regulator steroid_receptor_RNA_activator_protein -LRB- SRAP -RRB- are predictive for benefit from tamoxifen therapy in patients with estrogen_receptor-alpha -LRB- ER-a -RRB- - negative early breast_cancer -LRB- EBC -RRB- .
9371753	0	estrogen	81,89	estrogen_receptor-alpha	24,47	estrogen	estrogen receptor-alpha	MESH:D004967	13982(Tax:10090)	Chemical	Gene	reveal|dobj|START_ENTITY reveal|nsubj|responses responses|nmod|mice mice|amod|END_ENTITY	Estrogenic responses in estrogen_receptor-alpha deficient mice reveal a distinct estrogen signaling pathway .
9422719	0	estrogen	63,71	estrogen_receptor-alpha	38,61	estrogen	estrogen receptor-alpha	MESH:D004967	2099	Chemical	Gene	Determinants|dep|START_ENTITY Determinants|nmod|specificity specificity|nmod|END_ENTITY	Determinants of ligand specificity of estrogen_receptor-alpha : estrogen versus androgen discrimination .
9575432	5	estrogen	964,972	estrogen_receptor-alpha	847,870	estrogen	estrogen receptor-alpha	MESH:D004967	2099	Chemical	Gene	genes|compound|START_ENTITY expression|nmod|genes activation|nmod|expression END_ENTITY|appos|activation	These include variant or mutated estrogen_receptor-alpha , ligant independent activation of estrogen_receptor-alpha , altered expression of down-stream estrogen target genes , post receptor and pharmacological alterations .
21984905	0	estrogen	62,70	estrogen_receptor_a	106,125	estrogen	estrogen receptor a	MESH:D004967	2099	Chemical	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	The immunophilin-like protein XAP2 is a negative regulator of estrogen signaling through interaction with estrogen_receptor_a .
10097091	0	estrogen	14,22	estrogen_receptor_alpha	77,100	estrogen	estrogen receptor alpha	MESH:D004967	13982(Tax:10090)	Chemical	Gene	signaling|compound|START_ENTITY Disruption|nmod|signaling prevent|nsubj|Disruption prevent|nmod|uterus uterus|amod|END_ENTITY	Disruption of estrogen signaling does not prevent progesterone action in the estrogen_receptor_alpha knockout mouse uterus .
10102472	0	estrogen	92,100	estrogen_receptor_alpha	142,165	estrogen	estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	attenuated|nmod|START_ENTITY attenuated|xcomp|expressing expressing|dobj|END_ENTITY	The activation of plasminogen_activator_inhibitor-1 expression by IL-1beta is attenuated by estrogen in hepatoblastoma HepG2 cells expressing estrogen_receptor_alpha .
10486286	0	estrogen	50,58	estrogen_receptor_alpha	74,97	estrogen	estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	release|nmod|START_ENTITY stimulation|nmod|release mediated|nsubjpass|stimulation mediated|nmod|localized localized|compound|END_ENTITY	Nongenomic stimulation of nitric_oxide release by estrogen is mediated by estrogen_receptor_alpha localized in caveolae .
11325520	0	estrogen	68,76	estrogen_receptor_alpha	25,48	estrogen	estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	element|compound|START_ENTITY rate|nmod|element rate|nmod|END_ENTITY	The dissociation rate of estrogen_receptor_alpha from the consensus estrogen response element .
11557741	0	estrogen	11,19	estrogen_receptor_alpha	55,78	estrogen	estrogen receptor alpha	MESH:D004967	13982(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|response response|nmod|END_ENTITY	Effects of estrogen on the vascular_injury response in estrogen_receptor_alpha , beta -LRB- double -RRB- knockout mice .
11952337	0	estrogen	39,47	estrogen_receptor_alpha	69,92	estrogen	estrogen receptor alpha	MESH:D004967	791249(Tax:9796)	Chemical	Gene	metabolites|compound|START_ENTITY induced|nmod|metabolites damage|acl|induced damage|dep|role role|nmod|END_ENTITY	Oxidative DNA damage induced by equine estrogen metabolites : role of estrogen_receptor_alpha .
11959119	0	estrogen	127,135	estrogen_receptor_alpha	180,203	estrogen	estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	mRNA|amod|START_ENTITY pattern|nmod|mRNA mRNAs|dep|pattern deleted|dobj|mRNAs exon|acl|deleted Identification|nmod|exon distinct|nsubj|Identification distinct|nmod|that that|nmod|END_ENTITY	Identification of ten exon deleted ERbeta mRNAs in human ovary , breast , uterus and bone tissues : alternate splicing pattern of estrogen receptor beta mRNA is distinct from that of estrogen_receptor_alpha .
12074565	0	estrogen	57,65	estrogen_receptor_alpha	24,47	estrogen	estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	effect|compound|START_ENTITY mediates|dobj|effect mediates|nsubj|association association|nmod|END_ENTITY	Membrane association of estrogen_receptor_alpha mediates estrogen effect on MAPK activation .
12234690	0	estrogen	93,101	estrogen_receptor_alpha	132,155	estrogen	estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	element|amod|START_ENTITY element|nmod|gene gene|compound|END_ENTITY	Ligand-dependent transcriptional enhancement by DNA curvature between two half motifs of the estrogen response element in the human estrogen_receptor_alpha gene .
12297545	0	estrogen	136,144	estrogen_receptor_alpha	18,41	estrogen	estrogen receptor alpha	MESH:D004967	13982(Tax:10090)	Chemical	Gene	START_ENTITY|nsubjpass|Studies Studies|acl|using using|ccomp|demonstrate demonstrate|nsubj|uterus uterus|compound|END_ENTITY	Studies using the estrogen_receptor_alpha knockout uterus demonstrate that implantation but not decidualization-associated signaling is estrogen dependent .
12740031	0	estrogen	24,32	estrogen_receptor_alpha	96,119	estrogen	estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	beta|compound|START_ENTITY expression|nmod|beta expression|dep|comparison comparison|nmod|END_ENTITY	Placental expression of estrogen receptor beta and its hormone binding variant -- comparison with estrogen_receptor_alpha and a role for estrogen receptors in asymmetric division and differentiation of estrogen-dependent cells .
12878603	0	estrogen	10,18	estrogen_receptor_alpha	49,72	estrogen	estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	product-1|compound|START_ENTITY stimulates|nsubj|product-1 stimulates|dobj|activity activity|amod|END_ENTITY	Truncated estrogen receptor product-1 stimulates estrogen_receptor_alpha transcriptional activity by titration of repressor proteins .
12895004	0	estrogen	20,28	estrogen_receptor_alpha	66,89	estrogen	estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	beta|amod|START_ENTITY distribution|nmod|beta distinct|nsubj|distribution distinct|nmod|that that|nmod|END_ENTITY	The distribution of estrogen receptor beta is distinct to that of estrogen_receptor_alpha and the androgen_receptor in human skin and the pilosebaceous unit .
12943986	0	estrogen	77,85	estrogen_receptor_alpha	14,37	estrogen	estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	responsive|amod|START_ENTITY sites|amod|responsive mediating|nsubj|sites ligands|advcl|mediating ligands|nsubj|Activities Activities|nmod|END_ENTITY	Activities of estrogen_receptor_alpha - and beta-selective ligands at diverse estrogen responsive gene sites mediating transactivation or transrepression .
15138841	0	estrogen	136,144	estrogen_receptor_alpha	35,58	estrogen	estrogen receptor alpha	MESH:D004967	13982(Tax:10090)	Chemical	Gene	levels|compound|START_ENTITY male|nmod|levels Identification|nmod|male Identification|nmod|END_ENTITY	Identification and localization of estrogen_receptor_alpha - and beta-positive cells in adult male and female mouse intestine at various estrogen levels .
15940264	0	estrogen	34,42	estrogen_receptor_alpha	115,138	estrogen	estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	inhibitor|amod|START_ENTITY modulates|nsubj|inhibitor modulates|dobj|interaction interaction|nmod|cyclin_T1 cyclin_T1|compound|END_ENTITY	The breast cell growth inhibitor , estrogen down regulated gene 1 , modulates a novel functional interaction between estrogen_receptor_alpha and transcriptional elongation factor cyclin_T1 .
16087863	0	estrogen	121,129	estrogen_receptor_alpha	37,60	estrogen	estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	response|compound|START_ENTITY domain|nmod|response defines|dobj|domain reveals|ccomp|defines reveals|nsubj|analysis analysis|nmod|promoters promoters|compound|END_ENTITY	From the Cover : Location analysis of estrogen_receptor_alpha target promoters reveals that FOXA1 defines a domain of the estrogen response .
16138832	0	estrogen	152,160	estrogen_receptor_alpha	36,59	estrogen	estrogen receptor alpha	MESH:D004967	13982(Tax:10090)	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|domain domain|nmod|END_ENTITY	The activation function-1 domain of estrogen_receptor_alpha in uterine stromal cells is required for mouse but not human uterine epithelial response to estrogen .
16728493	0	estrogen	67,75	estrogen_receptor_alpha	98,121	estrogen	estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	metabolites|compound|START_ENTITY metabolites|nmod|END_ENTITY	Quantitative structure-activity relationship of various endogenous estrogen metabolites for human estrogen_receptor_alpha and beta subtypes : Insights into the structural determinants favoring a differential subtype binding .
16809442	0	estrogen	10,18	estrogen_receptor_alpha	63,86	estrogen	estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	beta|compound|START_ENTITY Impact|nmod|beta regulated|nsubj|Impact regulated|nmod|END_ENTITY	Impact of estrogen receptor beta on gene networks regulated by estrogen_receptor_alpha in breast_cancer cells .
16847062	0	estrogen	122,130	estrogen_receptor_alpha	77,100	estrogen	estrogen receptor alpha	MESH:D004967	13982(Tax:10090)	Chemical	Gene	binding|nmod|START_ENTITY elements|amod|binding elements|compound|END_ENTITY	Estrogen-induced proliferation of uterine epithelial cells is independent of estrogen_receptor_alpha binding to classical estrogen response elements .
17108141	0	estrogen	98,106	estrogen_receptor_alpha	45,68	estrogen	estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	action|compound|START_ENTITY confers|nmod|action confers|nsubj|Ciz1 Ciz1|appos|coactivator coactivator|nmod|END_ENTITY	Ciz1 , a Novel DNA-binding coactivator of the estrogen_receptor_alpha , confers hypersensitivity to estrogen action .
17395694	0	estrogen	105,113	estrogen_receptor_alpha	56,79	estrogen	estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	element|compound|START_ENTITY activate|dobj|element collaborate|xcomp|activate collaborate|nmod|END_ENTITY	Multiple transcription factor elements collaborate with estrogen_receptor_alpha to activate an inducible estrogen response element in the NKG2E gene .
17509633	0	estrogen	40,48	estrogen_receptor_alpha	13,36	estrogen	estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	beta|compound|START_ENTITY END_ENTITY|nmod|beta	The ratio of estrogen_receptor_alpha to estrogen receptor beta in adipose tissue is associated with leptin production and obesity .
17700529	0	estrogen	49,57	estrogen_receptor_alpha	75,98	estrogen	estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	beta|compound|START_ENTITY beta|nmod|END_ENTITY	A genome-wide study of the repressive effects of estrogen receptor beta on estrogen_receptor_alpha signaling in breast_cancer cells .
17909265	0	estrogen	91,99	estrogen_receptor_alpha	52,75	estrogen	estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	responsiveness|compound|START_ENTITY responsiveness|compound|END_ENTITY	Rho_GDP_dissociation_inhibitor_alpha interacts with estrogen_receptor_alpha and influences estrogen responsiveness .
18337247	0	estrogen	69,77	estrogen_receptor_alpha	34,57	estrogen	estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	binding|nmod|START_ENTITY elements|amod|binding elements|compound|END_ENTITY	A new small molecule inhibitor of estrogen_receptor_alpha binding to estrogen response elements blocks estrogen-dependent growth of cancer cells .
18354059	0	estrogen	25,33	estrogen_receptor_alpha	50,73	estrogen	estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	effects|nmod|START_ENTITY mediated|nsubjpass|effects mediated|nmod|END_ENTITY	Mitochondrial effects of estrogen are mediated by estrogen_receptor_alpha in brain endothelial cells .
18820009	0	estrogen	88,96	estrogen_receptor_alpha	63,86	estrogen	estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	metabolism|dep|START_ENTITY metabolism|compound|END_ENTITY	Possible difference in frequencies of genetic polymorphisms of estrogen_receptor_alpha , estrogen metabolism and P53 genes between estrogen_receptor-positive and - negative breast_cancers .
19414598	0	estrogen	16,24	estrogen_receptor_alpha	61,84	estrogen	estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	START_ENTITY|acl|signaling signaling|advcl|targeting targeting|dobj|mRNA mRNA|compound|END_ENTITY	miR-22 inhibits estrogen signaling by directly targeting the estrogen_receptor_alpha mRNA .
19439729	0	estrogen	9,17	estrogen_receptor_alpha	94,117	estrogen	estrogen receptor alpha	MESH:D004967	13982(Tax:10090)	Chemical	Gene	feedback|amod|START_ENTITY Impaired|dobj|feedback Impaired|nmod|deletion deletion|nmod|END_ENTITY	Impaired estrogen feedback and infertility in female mice with pituitary-specific deletion of estrogen_receptor_alpha -LRB- ESR1 -RRB- .
19509105	0	estrogen	61,69	estrogen_receptor_alpha	21,44	estrogen	estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	status|compound|START_ENTITY modulated|nmod|status modulated|nsubjpass|END_ENTITY	Vascular endothelial estrogen_receptor_alpha is modulated by estrogen status and related to endothelial function and endothelial_nitric_oxide_synthase in healthy women .
19526339	0	estrogen	96,104	estrogen_receptor_alpha	52,75	estrogen	estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	inverts|nmod|START_ENTITY inverts|nsubj|mutation mutation|nmod|helix helix|nmod|END_ENTITY	Breast_cancer-derived M543V mutation in helix 12 of estrogen_receptor_alpha inverts response to estrogen and SERMs .
20131258	0	estrogen	11,19	estrogen_receptor_alpha	113,136	estrogen	estrogen receptor alpha	MESH:D004967	13982(Tax:10090)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Endogenous estrogen regulation of inflammatory_arthritis and cytokine expression in male mice , predominantly via estrogen_receptor_alpha .
20535543	0	estrogen	66,74	estrogen_receptor_alpha	29,52	estrogen	estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	breast_cancer|compound|START_ENTITY signaling|nmod|breast_cancer END_ENTITY|acl|signaling	Let-7 family miRNAs regulate estrogen_receptor_alpha signaling in estrogen receptor positive breast_cancer .
21071990	0	estrogen	14,22	estrogen_receptor_alpha	60,83	estrogen	estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	beta|amod|START_ENTITY beta|nmod|END_ENTITY	Expression of estrogen receptor beta and phosphorylation of estrogen_receptor_alpha serine 167 correlate with progression-free survival in patients with metastatic breast_cancer treated with aromatase inhibitors .
21235772	0	estrogen	19,27	estrogen_receptor_alpha	115,138	estrogen	estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	beta|compound|START_ENTITY genome|compound|beta analysis|nmod|genome reveals|nsubj|analysis reveals|nmod|END_ENTITY	Global analysis of estrogen receptor beta binding to breast_cancer cell genome reveals an extensive interplay with estrogen_receptor_alpha for target gene regulation .
21458604	0	estrogen	38,46	estrogen_receptor_alpha	94,117	estrogen	estrogen receptor alpha	MESH:D004967	13982(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY loss|nmod|receptor effects|nmod|loss effects|acl|signaling signaling|nmod|deletion deletion|nmod|END_ENTITY	Distinct effects of loss of classical estrogen receptor signaling versus complete deletion of estrogen_receptor_alpha on bone .
21497463	0	estrogen	47,55	estrogen_receptor_alpha	22,45	estrogen	estrogen receptor alpha	MESH:D004967	791249(Tax:9796)	Chemical	Gene	beta|dep|START_ENTITY beta|compound|END_ENTITY	Immunolocalization of estrogen_receptor_alpha , estrogen receptor beta and androgen_receptor in the pre - , peri - and post-pubertal stallion testis .
23508069	0	estrogen	75,83	estrogen_receptor_alpha	29,52	estrogen	estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	correlated|xcomp|START_ENTITY correlated|nsubjpass|hypermethylation hypermethylation|nmod|gene gene|compound|END_ENTITY	Promoter hypermethylation of estrogen_receptor_alpha gene is correlated to estrogen receptor negativity in Iranian patients with sporadic breast_cancer .
25028072	0	estrogen	107,115	estrogen_receptor_alpha	41,64	estrogen	estrogen receptor alpha	MESH:D004967	13982(Tax:10090)	Chemical	Gene	treatment|compound|START_ENTITY effect|nmod|treatment expression|nmod|effect expression|compound|END_ENTITY	The role of total and cartilage-specific estrogen_receptor_alpha expression for the ameliorating effect of estrogen treatment on arthritis .
26056942	0	estrogen	32,40	estrogen_receptor_alpha	107,130	estrogen	estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	cells|compound|START_ENTITY cells|nmod|modulation modulation|nmod|END_ENTITY	Hispolon inhibits the growth of estrogen receptor positive human breast_cancer cells through modulation of estrogen_receptor_alpha .
26899418	0	estrogen	99,107	estrogen_receptor_alpha	37,60	estrogen	estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	elements|amod|START_ENTITY employing|dobj|elements docking|advcl|employing computational|xcomp|docking computational|nmod|selection selection|nmod|aptamer aptamer|nmod|END_ENTITY	In silico selection of an aptamer to estrogen_receptor_alpha using computational docking employing estrogen response elements as aptamer-alike molecules .
9280064	0	estrogen	35,43	estrogen_receptor_alpha	87,110	estrogen	estrogen receptor alpha	MESH:D004967	13982(Tax:10090)	Chemical	Gene	heterodimers|amod|START_ENTITY forms|dobj|heterodimers forms|nmod|END_ENTITY	Mouse estrogen_receptor_beta forms estrogen response element-binding heterodimers with estrogen_receptor_alpha .
9658195	0	estrogen	87,95	estrogen_receptor_alpha	25,48	estrogen	estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	agonists/antagonists|compound|START_ENTITY response|nmod|agonists/antagonists response|nmod|beta beta|compound|END_ENTITY	Differential response of estrogen_receptor_alpha and estrogen receptor beta to partial estrogen agonists/antagonists .
11181953	0	estrogen	34,42	estrogen_receptor_beta	8,30	estrogen	estrogen receptor beta	MESH:D004967	13983(Tax:10090)	Chemical	Gene	action|compound|START_ENTITY Role|nmod|action Role|nmod|END_ENTITY	Role of estrogen_receptor_beta in estrogen action .
17003276	0	estrogen	8,16	ghrelin	34,41	estrogen	ghrelin	MESH:D004967	59301(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Gastric estrogen directly induces ghrelin expression and production in the rat stomach .
17636176	0	estrogen	128,136	ghrelin	29,36	estrogen	ghrelin	MESH:D004967	59301(Tax:10116)	Chemical	Gene	modulated|nmod|START_ENTITY mechanism|acl:relcl|modulated effect|nmod|mechanism effect|nmod|END_ENTITY	Direct stimulatory effect of ghrelin on pituitary release of LH through a nitric_oxide-dependent mechanism that is modulated by estrogen .
23940093	0	estrogen	98,106	ghrelin	22,29	estrogen	ghrelin	MESH:D004967	59301(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY differences|dep|role differences|nmod|response response|compound|END_ENTITY	Gender differences in ghrelin response to chronic immobilization stress in rats : possible role of estrogen .
2586221	0	estrogen	92,100	glucose-6-phosphate_dehydrogenase	22,55	estrogen	glucose-6-phosphate dehydrogenase	MESH:D004967	24377(Tax:10116)	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|activity activity|amod|END_ENTITY	Modulation of hepatic glucose-6-phosphate_dehydrogenase activity in male and female rats by estrogen .
15350188	0	estrogen	61,69	glucose_transporter	27,46	estrogen	glucose transporter	MESH:D004967	6513	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Differential regulation of glucose_transporter expression by estrogen and progesterone in Ishikawa endometrial_cancer cells .
22016564	0	estrogen	50,58	glucose_transporter_4	25,46	estrogen	glucose transporter 4	MESH:D004967	20528(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	Epigenetic regulation of glucose_transporter_4 by estrogen receptor b. Glucose_transporter_4 -LRB- Glut4 -RRB- is an important regulator of cellular glucose uptake in adipose tissue and skeletal muscle .
11182142	0	estrogen	11,19	glyceraldehyde-3-phosphate_dehydrogenase	55,95	estrogen	glyceraldehyde-3-phosphate dehydrogenase	MESH:D004967	24383(Tax:10116)	Chemical	Gene	conjugates|compound|START_ENTITY conjugates|nmod|END_ENTITY	Binding of estrogen and progesterone-BSA conjugates to glyceraldehyde-3-phosphate_dehydrogenase -LRB- GAPDH -RRB- and the effects of the free steroids on GAPDH enzyme activity : physiological implications .
10537130	0	estrogen	86,94	gonadotropin-releasing_hormone	29,59	estrogen	gonadotropin-releasing hormone	MESH:D004967	25194(Tax:10116)	Chemical	Gene	receptor-alpha|compound|START_ENTITY expression|nmod|receptor-alpha gene|acl|expression gene|amod|END_ENTITY	Estrogen directly respresses gonadotropin-releasing_hormone -LRB- GnRH -RRB- gene expression in estrogen receptor-alpha -LRB- ERalpha -RRB- - and ERbeta-expressing GT1-7 GnRH neurons .
1107343	0	estrogen	37,45	gonadotropin-releasing_hormone	82,112	estrogen	gonadotropin-releasing hormone	MESH:D004967	2796	Chemical	Gene	characteristics|nmod|START_ENTITY effects|nsubj|characteristics effects|xcomp|END_ENTITY	Strength-duration characteristics of estrogen effects on gonadotropin response to gonadotropin-releasing_hormone in women .
12057733	0	estrogen	76,84	gonadotropin-releasing_hormone	23,53	estrogen	gonadotropin-releasing hormone	MESH:D004967	2796	Chemical	Gene	levels|compound|START_ENTITY effect|nmod|levels effect|nmod|treatment treatment|amod|END_ENTITY	Differential effect of gonadotropin-releasing_hormone analogue treatment on estrogen levels and sulfatase activity in uterine leiomyoma and myometrium .
12819297	0	estrogen	120,128	gonadotropin-releasing_hormone	155,185	estrogen	gonadotropin-releasing hormone	MESH:D004967	2796	Chemical	Gene	receptors|compound|START_ENTITY receptors|nmod|neurons neurons|amod|END_ENTITY	Regulation of cyclic_adenosine_3 ' ,5 ' - monophosphate signaling and pulsatile neurosecretion by Gi-coupled plasma membrane estrogen receptors in immortalized gonadotropin-releasing_hormone neurons .
12843281	0	estrogen	38,46	gonadotropin-releasing_hormone	58,88	estrogen	gonadotropin-releasing hormone	MESH:D004967	14714(Tax:10090)	Chemical	Gene	actions|compound|START_ENTITY mediates|dobj|actions mediates|nmod|neurons neurons|amod|END_ENTITY	Estrogen_receptor_beta mediates rapid estrogen actions on gonadotropin-releasing_hormone neurons in vivo .
15994752	0	estrogen	10,18	gonadotropin-releasing_hormone	101,131	estrogen	gonadotropin-releasing hormone	MESH:D004967	2796	Chemical	Gene	treatment|compound|START_ENTITY increases|nsubj|treatment increases|dobj|density density|nmod|transsexuals transsexuals|acl|receiving receiving|dobj|agonist agonist|amod|END_ENTITY	High dose estrogen treatment increases bone mineral density in male-to-female transsexuals receiving gonadotropin-releasing_hormone agonist in the absence of testosterone .
16752944	0	estrogen	4,12	gonadotropin-releasing_hormone	36,66	estrogen	gonadotropin-releasing hormone	MESH:D004967	2796	Chemical	Gene	myth|compound|START_ENTITY myth|dep|use use|nmod|agonists agonists|amod|END_ENTITY	The estrogen myth : potential use of gonadotropin-releasing_hormone agonists for the treatment of Alzheimer 's _ disease .
17046690	0	estrogen	14,22	gonadotropin-releasing_hormone	83,113	estrogen	gonadotropin-releasing hormone	MESH:D004967	2796	Chemical	Gene	receptor|compound|START_ENTITY Definition|nmod|receptor critical|nsubj|Definition critical|nmod|neurons neurons|amod|END_ENTITY	Definition of estrogen receptor pathway critical for estrogen positive feedback to gonadotropin-releasing_hormone neurons and fertility .
17046690	0	estrogen	53,61	gonadotropin-releasing_hormone	83,113	estrogen	gonadotropin-releasing hormone	MESH:D004967	2796	Chemical	Gene	feedback|amod|START_ENTITY critical|nmod|feedback critical|nmod|neurons neurons|amod|END_ENTITY	Definition of estrogen receptor pathway critical for estrogen positive feedback to gonadotropin-releasing_hormone neurons and fertility .
17962348	0	estrogen	92,100	gonadotropin-releasing_hormone	122,152	estrogen	gonadotropin-releasing hormone	MESH:D004967	2796	Chemical	Gene	beta|compound|START_ENTITY beta|nmod|GT1-7 GT1-7|amod|END_ENTITY	17beta-estradiol at physiological concentrations augments Ca -LRB- 2 + -RRB- - activated K + currents via estrogen receptor beta in the gonadotropin-releasing_hormone neuronal cell line GT1-7 .
1939651	0	estrogen	20,28	gonadotropin-releasing_hormone	53,83	estrogen	gonadotropin-releasing hormone	MESH:D004967	2796	Chemical	Gene	regulation|compound|START_ENTITY Evidence|nmod|regulation Evidence|nmod|gene gene|amod|END_ENTITY	Evidence for direct estrogen regulation of the human gonadotropin-releasing_hormone gene .
2138629	0	estrogen	26,34	gonadotropin-releasing_hormone	62,92	estrogen	gonadotropin-releasing hormone	MESH:D004967	2796	Chemical	Gene	deprivation|compound|START_ENTITY deprivation|nmod|agonists agonists|amod|END_ENTITY	Bone mass reduction after estrogen deprivation by long-acting gonadotropin-releasing_hormone agonists and its relation to pretreatment serum concentrations of 1,25-dihydroxyvitamin _ D3 .
2145765	0	estrogen	126,134	gonadotropin-releasing_hormone	81,111	estrogen	gonadotropin-releasing hormone	MESH:D004967	2796	Chemical	Gene	threshold|compound|START_ENTITY hypothesis|nsubj|threshold treated|parataxis|hypothesis treated|nmod|agonists agonists|amod|END_ENTITY	Efficacy and safety considerations in women with uterine_leiomyomas treated with gonadotropin-releasing_hormone agonists : the estrogen threshold hypothesis .
21868004	0	estrogen	130,138	gonadotropin-releasing_hormone	74,104	estrogen	gonadotropin-releasing hormone	MESH:D004967	2796	Chemical	Gene	pretreatment|compound|START_ENTITY protocol|nmod|pretreatment protocol|amod|END_ENTITY	Programming in vitro fertilization retrievals during working days after a gonadotropin-releasing_hormone antagonist protocol with estrogen pretreatment : does the length of exposure to estradiol impact on controlled ovarian_hyperstimulation outcomes ?
23609940	0	estrogen	143,151	gonadotropin-releasing_hormone	53,83	estrogen	gonadotropin-releasing hormone	MESH:D004967	2796	Chemical	Gene	therapy|amod|START_ENTITY undertaking|dobj|therapy END_ENTITY|xcomp|undertaking	Resumption of menstruation and pituitary response to gonadotropin-releasing_hormone in functional hypothalamic amenorrhea subjects undertaking estrogen replacement therapy .
3048539	0	estrogen	11,19	gonadotropin-releasing_hormone	36,66	estrogen	gonadotropin-releasing hormone	MESH:D004967	613033(Tax:9544)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|release release|amod|END_ENTITY	Effects of estrogen on hypothalamic gonadotropin-releasing_hormone release in castrated male rhesus_macaques .
3286227	0	estrogen	133,141	gonadotropin-releasing_hormone	84,114	estrogen	gonadotropin-releasing hormone	MESH:D004967	25194(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|dep|effect	In situ hybridization histochemistry for messenger ribonucleic acid -LRB- mRNA -RRB- encoding gonadotropin-releasing_hormone -LRB- GnRH -RRB- : effect of estrogen on cellular levels of GnRH mRNA in female rat brain .
3919050	0	estrogen	83,91	gonadotropin-releasing_hormone	128,158	estrogen	gonadotropin-releasing hormone	MESH:D004967	2796	Chemical	Gene	START_ENTITY|nmod|administration administration|nmod|END_ENTITY	Reduction in pituitary desensitization and prolongation of gonadotropin release by estrogen during continuous administration of gonadotropin-releasing_hormone in women : its antagonism by progesterone .
3937722	0	estrogen	32,40	gonadotropin-releasing_hormone	104,134	estrogen	gonadotropin-releasing hormone	MESH:D004967	2796	Chemical	Gene	effects|nmod|START_ENTITY surges|nsubj|effects surges|dep|induced induced|nmod|administration administration|nmod|END_ENTITY	Biphasic stimulatory effects of estrogen on gonadotropin surges induced by continuous administration of gonadotropin-releasing_hormone in women .
767352	0	estrogen	37,45	gonadotropin-releasing_hormone	82,112	estrogen	gonadotropin-releasing hormone	MESH:D004967	2796	Chemical	Gene	characteristics|nmod|START_ENTITY effects|nsubj|characteristics effects|xcomp|END_ENTITY	Strength-duration characteristics of estrogen effects on gonadotropin response to gonadotropin-releasing_hormone in women .
8027261	0	estrogen	98,106	gonadotropin-releasing_hormone	121,151	estrogen	gonadotropin-releasing hormone	MESH:D004967	2796	Chemical	Gene	production|compound|START_ENTITY production|dep|monkeys monkeys|amod|END_ENTITY	Recombinant human follicle-stimulating hormone stimulates multiple follicular growth , but minimal estrogen production in gonadotropin-releasing_hormone antagonist-treated monkeys : examining the role of luteinizing hormone in follicular development and steroidogenesis .
8288696	0	estrogen	14,22	gonadotropin-releasing_hormone	72,102	estrogen	gonadotropin-releasing hormone	MESH:D004967	2796	Chemical	Gene	replacement|compound|START_ENTITY enhance|nsubj|replacement enhance|dobj|effectiveness effectiveness|nmod|agonist agonist|amod|END_ENTITY	Physiological estrogen replacement may enhance the effectiveness of the gonadotropin-releasing_hormone agonist in the treatment of hirsutism .
8405523	0	estrogen	78,86	gonadotropin-releasing_hormone	10,40	estrogen	gonadotropin-releasing hormone	MESH:D004967	2796	Chemical	Gene	replacement|compound|START_ENTITY agonist|nmod|replacement agonist|amod|END_ENTITY	Long-term gonadotropin-releasing_hormone agonist with standard postmenopausal estrogen replacement failed to prevent vertebral bone_loss in premenopausal women .
8675575	0	estrogen	11,19	gonadotropin-releasing_hormone	61,91	estrogen	gonadotropin-releasing hormone	MESH:D004967	2796	Chemical	Gene	reverses|nsubj|START_ENTITY reverses|dobj|cognitive_deficits cognitive_deficits|acl|induced induced|nmod|agonist agonist|amod|END_ENTITY	`` Add-back '' estrogen reverses cognitive_deficits induced by a gonadotropin-releasing_hormone agonist in women with leiomyomata uteri .
8751279	0	estrogen	22,30	gonadotropin-releasing_hormone	89,119	estrogen	gonadotropin-releasing hormone	MESH:D004967	443529(Tax:9940)	Chemical	Gene	effect|nmod|START_ENTITY effect|acl|END_ENTITY	A transient effect of estrogen on calcium currents and electrophysiological responses to gonadotropin-releasing_hormone in ovine gonadotropes .
10233027	0	estrogen	11,19	growth_hormone	70,84	estrogen	growth hormone	MESH:D004967	2688	Chemical	Gene	Actions|nmod|START_ENTITY Actions|nmod|secretion secretion|amod|END_ENTITY	Actions of estrogen on pulsatile , nyctohemeral , and entropic modes of growth_hormone secretion .
10566634	0	estrogen	9,17	growth_hormone	52,66	estrogen	growth hormone	MESH:D004967	2688	Chemical	Gene	administration|compound|START_ENTITY Route|nmod|administration helps|nsubj|Route helps|xcomp|determine determine|dobj|dose dose|amod|END_ENTITY	Route of estrogen administration helps to determine growth_hormone -LRB- GH -RRB- replacement dose in GH-deficient adults .
11344188	0	estrogen	68,76	growth_hormone	20,34	estrogen	growth hormone	MESH:D004967	2688	Chemical	Gene	use|compound|START_ENTITY allows|dobj|use allows|nsubj|initiation initiation|nmod|treatment treatment|amod|END_ENTITY	Early initiation of growth_hormone treatment allows age-appropriate estrogen use in Turner 's _ syndrome .
11474872	0	estrogen	11,19	growth_hormone	83,97	estrogen	growth hormone	MESH:D004967	2688	Chemical	Gene	therapy|compound|START_ENTITY Effect|nmod|therapy Effect|acl|treated treated|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Effect of estrogen therapy on the growth of Turner_syndrome in girls treated with growth_hormone -RSB- .
11701433	0	estrogen	5,13	growth_hormone	51,65	estrogen	growth hormone	MESH:D004967	2688	Chemical	Gene	antagonizes|nsubj|START_ENTITY antagonizes|dobj|actions actions|nmod|END_ENTITY	Oral estrogen antagonizes the metabolic actions of growth_hormone in growth_hormone-deficient women .
12445839	0	estrogen	21,29	growth_hormone	53,67	estrogen	growth hormone	MESH:D004967	2688	Chemical	Gene	therapy|compound|START_ENTITY therapy|nmod|response response|amod|END_ENTITY	Effects of long-term estrogen replacement therapy on growth_hormone response to pyridostigmine in healthy postmenopausal women .
12795360	0	estrogen	116,124	growth_hormone	76,90	estrogen	growth hormone	MESH:D004967	2688	Chemical	Gene	androgen|compound|START_ENTITY modulation|nmod|androgen control|dep|modulation control|nmod|modes modes|nmod|secretion secretion|amod|END_ENTITY	Three-peptide control of pulsatile and entropic feedback-sensitive modes of growth_hormone secretion : modulation by estrogen and aromatizable androgen .
14715838	0	estrogen	181,189	growth_hormone	82,96	estrogen	growth hormone	MESH:D004967	2688	Chemical	Gene	facilitates|compound|START_ENTITY endogenous|nsubj|facilitates evidence|dep|endogenous release|dep|evidence release|nmod|END_ENTITY	Estradiol supplementation in postmenopausal women doubles rebound-like release of growth_hormone -LRB- GH -RRB- triggered by sequential infusion and withdrawal of somatostatin : evidence that estrogen facilitates endogenous GH-releasing hormone drive .
15131758	0	estrogen	25,33	growth_hormone	65,79	estrogen	growth hormone	MESH:D004967	2688	Chemical	Gene	Effects|nmod|START_ENTITY LY117018|dep|Effects LY117018|nmod|secretion secretion|amod|END_ENTITY	Effects of the selective estrogen receptor modulator LY117018 on growth_hormone secretion : In vitro studies .
15618363	0	estrogen	23,31	growth_hormone	35,49	estrogen	growth hormone	MESH:D004967	81668(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|synthesis synthesis|amod|END_ENTITY	Bipotential effects of estrogen on growth_hormone synthesis and storage in vitro .
16150906	0	estrogen	138,146	growth_hormone	38,52	estrogen	growth hormone	MESH:D004967	81668(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY actions|nmod|receptors evidence|nmod|actions restoration|dep|evidence restoration|nmod|expression expression|amod|END_ENTITY	Dehydroepiandrosterone restoration of growth_hormone gene expression in aging female rats , in vivo and in vitro : evidence for actions via estrogen receptors .
16246898	0	estrogen	13,21	growth_hormone	63,77	estrogen	growth hormone	MESH:D004967	14599(Tax:10090)	Chemical	Gene	administration|compound|START_ENTITY administration|nmod|response response|nmod|END_ENTITY	Influence of estrogen administration on the growth response to growth_hormone -LRB- GH -RRB- in GH-deficient mice .
1642149	0	estrogen	21,29	growth_hormone	48,62	estrogen	growth hormone	MESH:D004967	2688	Chemical	Gene	administration|compound|START_ENTITY administration|nmod|secretion secretion|amod|END_ENTITY	Impact of short-term estrogen administration on growth_hormone secretion and action : distinct route-dependent effects on connective and bone tissue metabolism .
17272397	0	estrogen	52,60	growth_hormone	14,28	estrogen	growth hormone	MESH:D004967	2688	Chemical	Gene	modulators|compound|START_ENTITY signaling|nmod|modulators END_ENTITY|acl|signaling	Regulation of growth_hormone signaling by selective estrogen receptor modulators occurs through suppression of protein tyrosine phosphatases .
1780953	0	estrogen	82,90	growth_hormone	22,36	estrogen	growth hormone	MESH:D004967	81668(Tax:10116)	Chemical	Gene	level|compound|START_ENTITY effects|nmod|level effects|nmod|glucocorticoids glucocorticoids|compound|END_ENTITY	Regulatory effects of growth_hormone , glucocorticoids , and thyroid hormone on the estrogen receptor level in the rat liver .
18319308	0	estrogen	121,129	growth_hormone	24,38	estrogen	growth hormone	MESH:D004967	2688	Chemical	Gene	effect|nmod|START_ENTITY levels|dep|effect levels|nmod|END_ENTITY	24-hour serum levels of growth_hormone , prolactin , and cortisol in pre - and postmenopausal women : the effect of combined estrogen and progestin treatment .
18797598	0	estrogen	18,26	growth_hormone	58,72	estrogen	growth hormone	MESH:D004967	2688	Chemical	Gene	replacement|compound|START_ENTITY influence|nmod|replacement -LSB-|dobj|influence -LSB-|nmod|activity activity|amod|END_ENTITY	-LSB- The influence of estrogen and progestogen replacement on growth_hormone activity in women with hypopituitarism -RSB- .
19463694	0	estrogen	88,96	growth_hormone	43,57	estrogen	growth hormone	MESH:D004967	81668(Tax:10116)	Chemical	Gene	pathways|amod|START_ENTITY transcription|nmod|pathways transcription|amod|END_ENTITY	In vitro exposure to xenoestrogens induces growth_hormone transcription and release via estrogen receptor-dependent pathways in rat pituitary GH3 cells .
19470834	0	estrogen	20,28	growth_hormone	65,79	estrogen	growth hormone	MESH:D004967	2688	Chemical	Gene	age|compound|START_ENTITY effects|nmod|age effects|nmod|secretion secretion|compound|END_ENTITY	Relative effects of estrogen , age , and visceral fat on pulsatile growth_hormone secretion in healthy women .
1991807	0	estrogen	54,62	growth_hormone	94,108	estrogen	growth hormone	MESH:D004967	2688	Chemical	Gene	therapy|compound|START_ENTITY therapy|nmod|END_ENTITY	Contrasting effects of oral and transdermal routes of estrogen replacement therapy on 24-hour growth_hormone -LRB- GH -RRB- secretion , insulin-like_growth_factor_I , and GH-binding protein in postmenopausal women .
20444909	0	estrogen	52,60	growth_hormone	24,38	estrogen	growth hormone	MESH:D004967	2688	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|regulation regulation|nmod|END_ENTITY	Paracrine regulation of growth_hormone secretion by estrogen in women .
21242654	0	estrogen	11,19	growth_hormone	23,37	estrogen	growth hormone	MESH:D004967	102171600	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|pulsatility pulsatility|amod|END_ENTITY	Effects of estrogen on growth_hormone pulsatility in peripheral blood and neuropeptide profiles in the cerebrospinal fluid of goats .
22319035	0	estrogen	87,95	growth_hormone	54,68	estrogen	growth hormone	MESH:D004967	2688	Chemical	Gene	modulators|compound|START_ENTITY axis|nmod|modulators axis|nsubj|difference difference|nmod|regulation regulation|nmod|END_ENTITY	Gender difference in the neuroendocrine regulation of growth_hormone axis by selective estrogen receptor modulators .
2440014	0	estrogen	113,121	growth_hormone	28,42	estrogen	growth hormone	MESH:D004967	2688	Chemical	Gene	therapy|compound|START_ENTITY effects|nmod|therapy proteins|dep|effects proteins|amod|END_ENTITY	Steroid-sensitive proteins , growth_hormone and somatomedin_C in prostatic_cancer : effects of parenteral and oral estrogen therapy .
2497615	0	estrogen	13,21	growth_hormone	40,54	estrogen	growth hormone	MESH:D004967	2688	Chemical	Gene	administration|compound|START_ENTITY Influence|nmod|administration Influence|nmod|response response|amod|END_ENTITY	Influence of estrogen administration on growth_hormone response to GHRH and L-Dopa in patients with Turner 's _ syndrome .
2884230	0	estrogen	10,18	growth_hormone	26,40	estrogen	growth hormone	MESH:D004967	2688	Chemical	Gene	START_ENTITY|nmod|response response|amod|END_ENTITY	Effect of estrogen on the growth_hormone response to the alpha-adrenergic agonist clonidine in women with menopausal_flushing .
3088024	0	estrogen	106,114	growth_hormone	14,28	estrogen	growth hormone	MESH:D004967	2688	Chemical	Gene	replacement|compound|START_ENTITY effect|nmod|replacement Regulation|dep|effect Regulation|nmod|secretion secretion|amod|END_ENTITY	Regulation of growth_hormone and somatomedin-C secretion in postmenopausal women : effect of physiological estrogen replacement .
3100282	0	estrogen	10,18	growth_hormone	26,40	estrogen	growth hormone	MESH:D004967	81668(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|response response|amod|END_ENTITY	Effect of estrogen on the growth_hormone -LRB- GH -RRB- secretory response to GH-releasing factor in the castrate adult female rat in vivo .
3946321	0	estrogen	27,35	growth_hormone	68,82	estrogen	growth hormone	MESH:D004967	2688	Chemical	Gene	Administration|nmod|START_ENTITY stimulates|nsubj|Administration stimulates|dobj|production production|amod|END_ENTITY	Administration of low-dose estrogen rapidly and directly stimulates growth_hormone production .
8045974	0	estrogen	15,23	growth_hormone	51,65	estrogen	growth hormone	MESH:D004967	2688	Chemical	Gene	priming|compound|START_ENTITY effects|nmod|priming effects|nmod|response response|amod|END_ENTITY	The effects of estrogen priming and puberty on the growth_hormone response to standardized treadmill exercise and arginine-insulin in normal girls and boys .
8380310	0	estrogen	11,19	growth_hormone	23,37	estrogen	growth hormone	MESH:D004967	2688	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of estrogen on growth_hormone following clonidine stimulation .
8404593	0	estrogen	17,25	growth_hormone	38,52	estrogen	growth hormone	MESH:D004967	81668(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY Induction|nmod|receptor Induction|nmod|substitution substitution|amod|END_ENTITY	Induction of the estrogen receptor by growth_hormone and glucocorticoid substitution in primary cultures of rat hepatocytes .
9312204	0	estrogen	39,47	growth_hormone	11,25	estrogen	growth hormone	MESH:D004967	81668(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|dose dose|amod|END_ENTITY	Effects of growth_hormone and low dose estrogen on bone growth and turnover in long bones of hypophysectomized rats .
1354846	0	estrogen	32,40	growth_hormone_releasing_hormone	72,104	estrogen	growth hormone releasing hormone	MESH:D004967	29446(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY effects|nmod|administration effects|nmod|END_ENTITY	Differential effects of in vivo estrogen administration on hypothalamic growth_hormone_releasing_hormone and somatostatin gene expression .
9473491	0	estrogen	40,48	hER_beta	64,72	estrogen	hER beta	MESH:D004967	2100	Chemical	Gene	beta|compound|START_ENTITY beta|appos|END_ENTITY	The complete primary structure of human estrogen receptor beta -LRB- hER_beta -RRB- and its heterodimerization with ER_alpha in vivo and in vitro .
11798733	0	estrogen	33,41	hERbeta	57,64	estrogen	hERbeta	MESH:D004967	2100	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	-LSB- Sequencing and cloning of human estrogen beta receptor -LRB- hERbeta -RRB- cDNA in human granulosa -RSB- .
11358677	0	estrogen	51,59	hEST1	78,83	estrogen	hEST1	MESH:D004967	6783	Chemical	Gene	sulfotransferase|compound|START_ENTITY sulfotransferase|appos|END_ENTITY	High metabolization of catecholestrogens by type 1 estrogen sulfotransferase -LRB- hEST1 -RRB- .
23672086	0	estrogen	74,82	hMLH1	0,5	estrogen	hMLH1	MESH:D004967	4292	Chemical	Gene	protein|compound|START_ENTITY patterns|nmod|protein causes|dobj|patterns causes|nsubj|status status|amod|END_ENTITY	hMLH1 promoter methylation status causes different expression patterns of estrogen receptor protein with endometrial lesion progression .
15048073	0	estrogen	53,61	hTERT	13,18	estrogen	hTERT	MESH:D004967	7015	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|expression expression|compound|END_ENTITY	Induction of hTERT expression and phosphorylation by estrogen via Akt cascade in human ovarian_cancer cell lines .
14695198	0	estrogen	44,52	heparanase	14,24	estrogen	heparanase	MESH:D004967	10855	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of heparanase gene expression by estrogen in breast_cancer .
9075616	0	estrogen	10,18	hepatic_triglyceride_lipase	42,69	estrogen	hepatic triglyceride lipase	MESH:D004967	3990	Chemical	Gene	therapy|amod|START_ENTITY Effect|nmod|therapy Effect|nmod|END_ENTITY	Effect of estrogen replacement therapy on hepatic_triglyceride_lipase , lipoprotein_lipase and lipids including apolipoprotein_E in climacteric and elderly women .
10819792	0	estrogen	14,22	hepatocyte_growth_factor	211,235	estrogen	hepatocyte growth factor	MESH:D004967	24446(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY Modulation|nmod|production ribonucleic_acid|nsubj|Modulation ribonucleic_acid|nmod|hormone hormone|compound|END_ENTITY	Modulation of estrogen production and 17beta-hydroxysteroid_dehydrogenase-type_1 , cytochrome P450 aromatase , c-met , and protein kinase Balpha messenger ribonucleic_acid content in rat ovarian granulosa cells by hepatocyte_growth_factor and follicle-stimulating hormone .
7988745	0	estrogen	58,66	hepatocyte_growth_factor	14,38	estrogen	hepatocyte growth factor	MESH:D004967	15234(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Modulation of hepatocyte_growth_factor gene expression by estrogen in mouse ovary .
9115298	0	estrogen	39,47	hsp90	25,30	estrogen	hsp90	MESH:D004967	3320	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	Selective interaction of hsp90 with an estrogen receptor ligand-binding domain containing a point mutation .
19429433	0	estrogen	96,104	iNOS	143,147	estrogen	iNOS	MESH:D004967	18126(Tax:10090)	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	The anti-inflammatory activities of Tanshinone_IIA , an active component of TCM , are mediated by estrogen receptor activation and inhibition of iNOS .
8405521	0	estrogen	29,37	insulin	41,48	estrogen	insulin	MESH:D004967	3630	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|sensitivity sensitivity|compound|END_ENTITY	A possible bimodal effect of estrogen on insulin sensitivity in postmenopausal women and the attenuating effect of added progestin .
19585556	0	estrogen	41,49	insulin-like_growth_factor-I	85,113	estrogen	insulin-like growth factor-I	MESH:D004967	3479	Chemical	Gene	exposure|amod|START_ENTITY exposure|nmod|END_ENTITY	Relationships between critical period of estrogen exposure and circulating levels of insulin-like_growth_factor-I -LRB- IGF-I -RRB- in breast_cancer : evidence from a case-control study .
19778547	0	estrogen	15,23	insulin-like_growth_factor-I	39,67	estrogen	insulin-like growth factor-I	MESH:D004967	3479	Chemical	Gene	receptors|compound|START_ENTITY receptors|nmod|END_ENTITY	Interaction of estrogen receptors with insulin-like_growth_factor-I and Wnt signaling in the nervous system .
20198387	0	estrogen	89,97	insulin-like_growth_factor-I	15,43	estrogen	insulin-like growth factor-I	MESH:D004967	16000(Tax:10090)	Chemical	Gene	proliferation|compound|START_ENTITY synthesis|nmod|proliferation regulation|nmod|synthesis Involvement|nmod|regulation Involvement|nmod|END_ENTITY	Involvement of insulin-like_growth_factor-I for the regulation of prolactin synthesis by estrogen and postnatal proliferation of lactotrophs in the mouse anterior pituitary .
24363252	0	estrogen	123,131	insulin-like_growth_factor-I	13,41	estrogen	insulin-like growth factor-I	MESH:D004967	3479	Chemical	Gene	regardless|nmod|START_ENTITY weight_gain|advmod|regardless related|xcomp|weight_gain related|nsubj|END_ENTITY	Bioavailable insulin-like_growth_factor-I inversely related to weight_gain in postmenopausal women regardless of exogenous estrogen .
2546740	0	estrogen	62,70	insulin-like_growth_factor-I	8,36	estrogen	insulin-like growth factor-I	MESH:D004967	24482(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY receptors|dep|regulation receptors|compound|END_ENTITY	Uterine insulin-like_growth_factor-I receptors : regulation by estrogen and variation throughout the estrous cycle .
9600784	0	estrogen	11,19	insulin-like_growth_factor-I	44,72	estrogen	insulin-like growth factor-I	MESH:D004967	24482(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|concentration concentration|nmod|END_ENTITY	Effects of estrogen on the concentration of insulin-like_growth_factor-I in rat bone matrix .
10342835	0	estrogen	119,127	insulin-like_growth_factor-binding_protein-4	30,74	estrogen	insulin-like growth factor-binding protein-4	MESH:D004967	3487	Chemical	Gene	complexes|amod|START_ENTITY role|nmod|complexes activation|dep|role activation|nmod|cells cells|amod|END_ENTITY	Transcriptional activation of insulin-like_growth_factor-binding_protein-4 by 17beta-estradiol in MCF-7 cells : role of estrogen receptor-Sp1 complexes .
8705735	0	estrogen	69,77	insulin-like_growth_factor-binding_protein-4	113,157	estrogen	insulin-like growth factor-binding protein-4	MESH:D004967	3487	Chemical	Gene	production|amod|START_ENTITY production|acl|END_ENTITY	Potential mechanism of estrogen-mediated decrease in bone formation : estrogen increases production of inhibitory insulin-like_growth_factor-binding_protein-4 .
8869589	0	estrogen	80,88	insulin-like_growth_factor-binding_protein-4	14,58	estrogen	insulin-like growth factor-binding protein-4	MESH:D004967	3487	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Regulation of insulin-like_growth_factor-binding_protein-4 protease activity by estrogen and parathyroid_hormone in SaOS-2 cells : implications for the pathogenesis of postmenopausal_osteoporosis .
15302288	0	estrogen	29,37	insulin-like_growth_factor-i	62,90	estrogen	insulin-like growth factor-i	MESH:D004967	3479	Chemical	Gene	START_ENTITY|nmod|raloxifene raloxifene|nmod|serum serum|amod|END_ENTITY	Effects of conjugated equine estrogen vs. raloxifene on serum insulin-like_growth_factor-i and insulin-like_growth_factor_binding_protein-3 : a 2-year , double-blind , placebo-controlled study .
10319328	0	estrogen	76,84	insulin_receptor_substrate-1	99,127	estrogen	insulin receptor substrate-1	MESH:D004967	3667	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Enhancement of insulin-like growth factor signaling in human breast_cancer : estrogen regulation of insulin_receptor_substrate-1 expression in vitro and in vivo .
11138340	0	estrogen	11,19	interleukin-6	23,36	estrogen	interleukin-6	MESH:D004967	3569	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|production production|amod|END_ENTITY	Effects of estrogen on interleukin-6 production in rheumatoid fibroblast-like synoviocytes .
12353531	0	estrogen	11,19	interleukin-6	118,131	estrogen	interleukin-6	MESH:D004967	24498(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|dep|evaluation evaluation|nmod|expression expression|nmod|mRNA mRNA|amod|END_ENTITY	Effects of estrogen on tail suspension-induced disuse atrophy in ovariectomized rats : evaluation of the expression of interleukin-6 mRNA in the femur .
15831279	0	estrogen	13,21	interleukin-6	36,49	estrogen	interleukin-6	MESH:D004967	3569	Chemical	Gene	production|compound|START_ENTITY production|nmod|line line|amod|END_ENTITY	Reduction of estrogen production by interleukin-6 in a human granulosa_tumor cell line may have implications for endometriosis-associated infertility .
1621100	0	estrogen	39,47	interleukin-6	67,80	estrogen	interleukin-6	MESH:D004967	16193(Tax:10090)	Chemical	Gene	loss|compound|START_ENTITY development|nmod|loss development|dep|mediation mediation|nmod|END_ENTITY	Increased osteoclast development after estrogen loss : mediation by interleukin-6 .
18160129	0	estrogen	107,115	interleukin-6	78,91	estrogen	interleukin-6	MESH:D004967	3569	Chemical	Gene	beta|amod|START_ENTITY production|nmod|beta production|amod|END_ENTITY	Effects of estradiol on regulation of corticotropin-releasing_factor gene and interleukin-6 production via estrogen receptor type beta in hypothalamic 4B cells .
19435922	0	estrogen	90,98	interleukin-6	29,42	estrogen	interleukin-6	MESH:D004967	3569	Chemical	Gene	receptor-positive|compound|START_ENTITY patients|nmod|receptor-positive predict|nmod|patients predict|nsubj|variants variants|nmod|promoter promoter|amod|END_ENTITY	Host genetic variants in the interleukin-6 promoter predict poor outcome in patients with estrogen receptor-positive , node-positive_breast_cancer .
19533603	0	estrogen	10,18	interleukin-6	66,79	estrogen	interleukin-6	MESH:D004967	16193(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY modulators|nsubj|receptor modulators|xcomp|decrease decrease|dobj|production production|acl|END_ENTITY	Selective estrogen receptor modulators decrease the production of interleukin-6 and interferon-gamma-inducible_protein-10 by astrocytes exposed to inflammatory challenge in vitro .
20546720	0	estrogen	23,31	interleukin-6	55,68	estrogen	interleukin-6	MESH:D004967	3569	Chemical	Gene	receptor|compound|START_ENTITY Influence|nmod|receptor modulators|nsubj|Influence modulators|nmod|expression expression|amod|END_ENTITY	Influence of selective estrogen receptor modulators on interleukin-6 expression in human retinal pigment epithelial cells -LRB- ARPE-19 -RRB- .
8393776	0	estrogen	78,86	interleukin-6	10,23	estrogen	interleukin-6	MESH:D004967	16193(Tax:10090)	Chemical	Gene	withdrawal|compound|START_ENTITY marrow|nmod|withdrawal production|nmod|marrow production|amod|END_ENTITY	Increased interleukin-6 production by murine bone marrow and bone cells after estrogen withdrawal .
8822343	0	estrogen	117,125	interleukin-6	18,31	estrogen	interleukin-6	MESH:D004967	3569	Chemical	Gene	receptors|compound|START_ENTITY levels|nmod|receptors line|nmod|levels production|nmod|line production|amod|END_ENTITY	Estrogen inhibits interleukin-6 production and gene expression in a human osteoblastic cell line with high levels of estrogen receptors .
9402940	0	estrogen	213,221	interleukin-6	131,144	estrogen	interleukin-6	MESH:D004967	3569	Chemical	Gene	therapy|compound|START_ENTITY Comparison|nmod|therapy Comparison|nmod|concentrations concentrations|amod|END_ENTITY	Comparison of alveolar_bone_loss , alveolar_bone_density and second metacarpal bone density , salivary and gingival crevicular fluid interleukin-6 concentrations in healthy premenopausal and postmenopausal women on estrogen therapy .
8224758	0	estrogen	10,18	intestinal_alkaline_phosphatase	80,111	estrogen	intestinal alkaline phosphatase	MESH:D004967	248	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of estrogen in relation to dietary vitamin_D3 and calcium on activity of intestinal_alkaline_phosphatase and Ca-ATPase in immature chicks .
11026574	0	estrogen	44,52	keratin_19	14,24	estrogen	keratin 19	MESH:D004967	3880	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of keratin_19 gene expression by estrogen in human breast_cancer cells and identification of the estrogen responsive gene region .
1610894	0	estrogen	56,64	kininogen	27,36	estrogen	kininogen	MESH:D004967	288001(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Differential regulation of kininogen gene expression by estrogen and progesterone in vivo .
10505667	0	estrogen	45,53	lactoferrin	14,25	estrogen	lactoferrin	MESH:D004967	17002(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Regulation of lactoferrin gene expression by estrogen and epidermal_growth_factor : molecular mechanism .
1480183	0	estrogen	40,48	lactoferrin	71,82	estrogen	lactoferrin	MESH:D004967	17002(Tax:10090)	Chemical	Gene	action|compound|START_ENTITY action|acl:relcl|regulates regulates|dobj|gene gene|compound|END_ENTITY	Differential molecular mechanism of the estrogen action that regulates lactoferrin gene in human and mouse .
17320339	0	estrogen	69,77	lactoferrin	14,25	estrogen	lactoferrin	MESH:D004967	17002(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY Expression|dep|effects Expression|nmod|END_ENTITY	Expression of lactoferrin in the boar epididymis : effects of reduced estrogen .
8441416	0	estrogen	44,52	lactoferrin	95,106	estrogen	lactoferrin	MESH:D004967	17002(Tax:10090)	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|gene gene|compound|END_ENTITY	COUP-TF acts as a competitive repressor for estrogen receptor-mediated activation of the mouse lactoferrin gene .
8593866	0	estrogen	37,45	lactoferrin	6,17	estrogen	lactoferrin	MESH:D004967	17002(Tax:10090)	Chemical	Gene	factor|compound|START_ENTITY marker|nmod|factor gene|dep|marker gene|compound|END_ENTITY	Mouse lactoferrin gene : a marker for estrogen and epidermal growth factor .
9607801	0	estrogen	117,125	lactoferrin	42,53	estrogen	lactoferrin	MESH:D004967	17002(Tax:10090)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|genes genes|compound|END_ENTITY	Differential spatiotemporal regulation of lactoferrin and progesterone_receptor genes in the mouse uterus by primary estrogen , catechol estrogen , and xenoestrogen .
10741011	0	estrogen	64,72	leptin	12,18	estrogen	leptin	MESH:D004967	3952	Chemical	Gene	administration|nmod|START_ENTITY levels|nmod|administration levels|compound|END_ENTITY	Increase of leptin levels following exogenous administration of estrogen in women with normal menstruation .
11369444	0	estrogen	11,19	leptin	23,29	estrogen	leptin	MESH:D004967	3952	Chemical	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Effects of estrogen on leptin gene promoter activation in MCF-7_breast_cancer and JEG-3 choriocarcinoma cells : selective regulation via estrogen_receptors alpha and beta .
11847470	0	estrogen	11,19	leptin	29,35	estrogen	leptin	MESH:D004967	25608(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Effects of estrogen on serum leptin levels and leptin mRNA expression in adipose tissue in rats .
17487372	0	estrogen	71,79	leptin	11,17	estrogen	leptin	MESH:D004967	3952	Chemical	Gene	receptor|amod|START_ENTITY relationship|nmod|receptor Effects|nmod|relationship Effects|nmod|END_ENTITY	Effects of leptin on human breast_cancer cell lines in relationship to estrogen receptor and HER2 status .
17638985	0	estrogen	10,18	leptin	22,28	estrogen	leptin	MESH:D004967	280836(Tax:9913)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of estrogen on leptin and expression of leptin_receptor transcripts in prepubertal dairy heifers .
18973889	0	estrogen	54,62	leptin	104,110	estrogen	leptin	MESH:D004967	3952	Chemical	Gene	contraceptives|nmod|START_ENTITY effects|nmod|contraceptives effects|nmod|END_ENTITY	The effects of oral contraceptives including low-dose estrogen and drospirenone on the concentration of leptin and ghrelin in polycystic_ovary_syndrome .
22197627	0	estrogen	77,85	leptin	129,135	estrogen	leptin	MESH:D004967	3952	Chemical	Gene	functions|compound|START_ENTITY lecture|dep|functions lecture|dep|focus focus|nmod|expression expression|compound|END_ENTITY	Elsevier Trophoblast Research Award lecture : Molecular mechanisms underlying estrogen functions in trophoblastic cells -- focus on leptin expression .
22310000	0	estrogen	106,114	leptin	14,20	estrogen	leptin	MESH:D004967	3952	Chemical	Gene	receptor|compound|START_ENTITY alpha|nsubj|receptor involves|xcomp|alpha involves|nsubj|Regulation Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of leptin expression by 17beta-estradiol in human placental cells involves membrane associated estrogen receptor alpha .
22526491	0	estrogen	82,90	leptin	14,20	estrogen	leptin	MESH:D004967	3952	Chemical	Gene	receptors|compound|START_ENTITY role|nmod|receptors Inhibition|dep|role Inhibition|nmod|expression expression|amod|END_ENTITY	Inhibition of leptin gene expression and secretion by silibinin : possible role of estrogen receptors .
24149922	0	estrogen	23,31	leptin	83,89	estrogen	leptin	MESH:D004967	3952	Chemical	Gene	therapy|compound|START_ENTITY promotes|nsubj|therapy promotes|dobj|maintenance maintenance|nmod|effects effects|nmod|END_ENTITY	Is there evidence that estrogen therapy promotes weight maintenance via effects on leptin ?
25866478	0	estrogen	81,89	leptin	18,24	estrogen	leptin	MESH:D004967	3952	Chemical	Gene	receptors|compound|START_ENTITY inhibits|nmod|receptors inhibits|dobj|expression expression|amod|END_ENTITY	Curcumin inhibits leptin gene expression and secretion in breast_cancer cells by estrogen receptors .
6694985	0	estrogen	10,18	lipoprotein_lipase	22,40	estrogen	lipoprotein lipase	MESH:D004967	24539(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Effect of estrogen on lipoprotein_lipase activity and cytoplasmic progestin binding sites in lean and obese Zucker rats .
15044370	0	estrogen	53,61	low-density_lipoprotein_receptor	4,36	estrogen	low-density lipoprotein receptor	MESH:D004967	300438(Tax:10116)	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	The low-density_lipoprotein_receptor is regulated by estrogen and forms a functional complex with the estrogen-regulated protein ezrin in pituitary GH3 somatolactotropes .
9359909	0	estrogen	98,106	low-density_lipoprotein_receptor	41,73	estrogen	low-density lipoprotein receptor	MESH:D004967	300438(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY responsiveness|nmod|treatment responsiveness|nmod|END_ENTITY	Independent responsiveness of frog liver low-density_lipoprotein_receptor and HMGCoA_reductase to estrogen treatment .
1097463	0	estrogen	12,20	luteinizing_hormone-releasing_factor	72,108	estrogen	luteinizing hormone-releasing factor	MESH:D004967	153222	Chemical	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of estrogen in the modulation of pituitary sensitivity of LRF -LRB- luteinizing_hormone-releasing_factor -RRB- in men .
4598115	0	estrogen	21,29	luteinizing_hormone-releasing_factor	85,121	estrogen	luteinizing hormone-releasing factor	MESH:D004967	153222	Chemical	Gene	Effects|nmod|START_ENTITY responsiveness|nsubj|Effects responsiveness|nmod|END_ENTITY	Effects of exogenous estrogen and progestin on pituitary responsiveness to synthetic luteinizing_hormone-releasing_factor .
10965924	0	estrogen	13,21	luteinizing_hormone-releasing_hormone	98,135	estrogen	luteinizing hormone-releasing hormone	MESH:D004967	25194(Tax:10116)	Chemical	Gene	acid|amod|START_ENTITY Detection|nmod|acid Detection|nmod|neurons neurons|amod|END_ENTITY	Detection of estrogen receptor-beta messenger ribonucleic acid and 125I-estrogen binding sites in luteinizing_hormone-releasing_hormone neurons of the rat brain .
15280536	0	estrogen	102,110	luteinizing_hormone-releasing_hormone	39,76	estrogen	luteinizing hormone-releasing hormone	MESH:D004967	25194(Tax:10116)	Chemical	Gene	reversed|nmod|START_ENTITY reversed|nsubjpass|effect effect|nmod|anandamide anandamide|nmod|secretion secretion|amod|END_ENTITY	The inhibitory effect of anandamide on luteinizing_hormone-releasing_hormone secretion is reversed by estrogen .
19210377	0	estrogen	11,19	luteinizing_hormone-releasing_hormone	110,147	estrogen	luteinizing hormone-releasing hormone	MESH:D004967	25194(Tax:10116)	Chemical	Gene	transplants|compound|START_ENTITY Effects|nmod|transplants release|nsubj|Effects release|xcomp|END_ENTITY	Effects of estrogen and ectopic pituitary transplants on the responsiveness of pituitary prolactin release to luteinizing_hormone-releasing_hormone and dopamine .
1986922	0	estrogen	87,95	luteinizing_hormone-releasing_hormone	29,66	estrogen	luteinizing hormone-releasing hormone	MESH:D004967	100135531(Tax:10141)	Chemical	Gene	responsive|amod|START_ENTITY neurons|amod|responsive evidence|nmod|neurons evidence|nmod|control control|amod|END_ENTITY	Ultrastructural evidence for luteinizing_hormone-releasing_hormone neuronal control of estrogen responsive neurons in the preoptic area .
2674693	0	estrogen	24,32	luteinizing_hormone-releasing_hormone	36,73	estrogen	luteinizing hormone-releasing hormone	MESH:D004967	25194(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Differential effects of estrogen on luteinizing_hormone-releasing_hormone gene expression in slice explant cultures prepared from specific rat forebrain regions .
3288508	0	estrogen	15,23	luteinizing_hormone-releasing_hormone	58,95	estrogen	luteinizing hormone-releasing hormone	MESH:D004967	2796	Chemical	Gene	effect|nmod|START_ENTITY -LSB-|dobj|effect -LSB-|nmod|patterns patterns|nmod|END_ENTITY	-LSB- The effect of estrogen on episodic secretory patterns of luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- and luteinizing hormone -LRB- LH -RRB- in hypergonadotropic_hypogonadism -RSB- .
7536660	0	estrogen	145,153	luteinizing_hormone-releasing_hormone	36,73	estrogen	luteinizing hormone-releasing hormone	MESH:D004967	25194(Tax:10116)	Chemical	Gene	dependency|compound|START_ENTITY dimorphism|dobj|dependency dimorphism|nmod|copackaging copackaging|nmod|END_ENTITY	Sexual dimorphism in copackaging of luteinizing_hormone-releasing_hormone and galanin into neurosecretory vesicles of hypophysiotrophic neurons : estrogen dependency .
7628399	0	estrogen	11,19	luteinizing_hormone-releasing_hormone	40,77	estrogen	luteinizing hormone-releasing hormone	MESH:D004967	25194(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|amod|END_ENTITY	Effects of estrogen and progesterone on luteinizing_hormone-releasing_hormone messenger ribonucleic_acid levels : consideration of temporal and neuroanatomical variables .
8425492	0	estrogen	29,37	luteinizing_hormone-releasing_hormone	41,78	estrogen	luteinizing hormone-releasing hormone	MESH:D004967	613033(Tax:9544)	Chemical	Gene	START_ENTITY|nmod|release release|amod|END_ENTITY	Negative feedback effects of estrogen on luteinizing_hormone-releasing_hormone release occur in pubertal , but not prepubertal , ovariectomized female rhesus_monkeys .
6988205	0	estrogen	11,19	luteinizing_hormone_releasing_hormone	23,60	estrogen	luteinizing hormone releasing hormone	MESH:D004967	25194(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of estrogen on luteinizing_hormone_releasing_hormone in a hypothalamic synaptosomal fraction from the ovariectomized rat .
9436641	0	estrogen	92,100	luteinizing_hormone_releasing_hormone	19,56	estrogen	luteinizing hormone releasing hormone	MESH:D004967	14714(Tax:10090)	Chemical	Gene	cancers|amod|START_ENTITY growth|nmod|cancers inhibit|dobj|growth anlalogs|xcomp|inhibit anlalogs|nsubj|END_ENTITY	Targeted cytotoxic luteinizing_hormone_releasing_hormone -LRB- LH-RH -RRB- anlalogs inhibit growth of estrogen independent MXT mouse mammary cancers in vivo by decreasing cell proliferation and inducing apoptosis .
8782086	1	estrogen	148,156	mER	167,170	estrogen	mER	MESH:D004967	17289(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	The mouse estrogen receptor -LRB- mER -RRB- exhibits ligand stereochemical specificity for indenestrol_A -LRB- IA -RRB- , a stilbestrol_estrogen .
23302124	0	estrogen	11,19	matrix_GLA_protein	41,59	estrogen	matrix GLA protein	MESH:D004967	25333(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of estrogen on the expression of matrix_GLA_protein in ovariectomized SD rats -RSB- .
15583471	0	estrogen	10,18	melanocortin-3_receptor	22,45	estrogen	melanocortin-3 receptor	MESH:D004967	17201(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effect of estrogen on melanocortin-3_receptor mRNA expression in mouse pituitary glands in vivo and in vitro .
24781337	0	estrogen	83,91	miR-21	7,13	estrogen	miR-21	MESH:D004967	406991	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|expression expression|amod|END_ENTITY	Higher miR-21 expression in invasive breast_carcinomas is associated with positive estrogen and progesterone_receptor status in patients from Serbia .
9698044	0	estrogen	27,35	monoamine_oxidase_A_and_B	39,64	estrogen	monoamine oxidase A and B	MESH:D004967	29253;25750	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Tissue-specific effects of estrogen on monoamine_oxidase_A_and_B in the rat .
24235231	0	estrogen	33,41	mucin	13,18	estrogen	mucin	MESH:D004967	100508689	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|expression expression|compound|END_ENTITY	Induction of mucin expression by estrogen and lipopolysaccharide in the lower oviductal segments in hens .
16890325	0	estrogen	10,18	neprilysin	22,32	estrogen	neprilysin	MESH:D004967	24590(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of estrogen on neprilysin expression in uterus and kidney of Sprague-Dawley normotensive and heterozygous -LRB- mRen2 -RRB- 27-transgenic hypertensive rats .
19912812	0	estrogen	11,19	neurokinin_B	30,42	estrogen	neurokinin B	MESH:D004967	29191(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|amod|END_ENTITY	Continuous estrogen decreases neurokinin_B expression in the rat arcuate nucleus .
1696887	0	estrogen	102,110	neuropeptide	18,30	estrogen	neuropeptide	MESH:D004967	379044(Tax:10116)	Chemical	Gene	status|compound|START_ENTITY manipulation|nmod|status pituitary|nmod|manipulation expression|nmod|pituitary expression|amod|END_ENTITY	The regulation of neuropeptide expression in rat anterior pituitary following chronic manipulation of estrogen status : a comparison between substance P , neuropeptide Y , neurotensin , and vasoactive intestinal peptide .
9843642	0	estrogen	31,39	neurotensin	11,22	estrogen	neurotensin	MESH:D004967	299757(Tax:10116)	Chemical	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	Changes in neurotensin mRNA by estrogen in the female rat preoptic area during aging : an in situ hybridization histochemistry study .
16210014	0	estrogen	48,56	nitric_oxide_synthase	14,35	estrogen	nitric oxide synthase	MESH:D004967	4843	Chemical	Gene	isoforms|nmod|START_ENTITY isoforms|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of nitric_oxide_synthase isoforms by estrogen in the human endometrium .
17327034	0	estrogen	14,22	nm23-H1	40,47	estrogen	nm23-H1	MESH:D004967	4830	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|expression expression|amod|END_ENTITY	-LSB- Influence of estrogen and progestin on nm23-H1 expression in epithelial_ovarian_cancer cell lines via activation of phosphorylation signaling -RSB- .
16632200	0	estrogen	10,18	occludin	40,48	estrogen	occludin	MESH:D004967	18260(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	Effect of estrogen on the expression of occludin in ovariectomized mouse brain .
8495798	0	estrogen	67,75	ornithine-delta-aminotransferase	25,57	estrogen	ornithine-delta-aminotransferase	MESH:D004967	4942	Chemical	Gene	control|nmod|START_ENTITY control|nmod|END_ENTITY	Translational control of ornithine-delta-aminotransferase -LRB- OAT -RRB- by estrogen .
12353530	0	estrogen	10,18	osteocalcin	56,67	estrogen	osteocalcin	MESH:D004967	81613(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|mRNA mRNA|compound|END_ENTITY	Effect of estrogen and tail-suspension on expression of osteocalcin mRNA in femur of ovariectomized rats .
1932893	0	estrogen	11,19	osteocalcin	43,54	estrogen	osteocalcin	MESH:D004967	81613(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|compound|END_ENTITY	Effects of estrogen and tamoxifen on serum osteocalcin levels in ovariectomized rats .
11932280	0	estrogen	10,18	osteoprotegerin	54,69	estrogen	osteoprotegerin	MESH:D004967	4982	Chemical	Gene	versus|compound|START_ENTITY Effect|nmod|versus testosterone|nsubj|Effect testosterone|advcl|circulating circulating|dobj|levels levels|compound|END_ENTITY	Effect of estrogen versus testosterone on circulating osteoprotegerin and other cytokine levels in normal elderly men .
12633785	0	estrogen	15,23	osteoprotegerin	27,42	estrogen	osteoprotegerin	MESH:D004967	4982	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of estrogen on osteoprotegerin , RANKL , and estrogen_receptor expression in human osteoblasts .
16624776	0	estrogen	11,19	osteoprotegerin	23,38	estrogen	osteoprotegerin	MESH:D004967	25341(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expressions expressions|compound|END_ENTITY	-LSB- Effect of estrogen on osteoprotegerin , osteoclast_differentiation_factor and macrophage_colony_stimulating_factor mRNA expressions in ovariectomized rat bone tissue -RSB- .
18771377	0	estrogen	103,111	osteoprotegerin	33,48	estrogen	osteoprotegerin	MESH:D004967	4982	Chemical	Gene	beta|amod|START_ENTITY regulates|nmod|beta regulates|dobj|expression expression|nmod|END_ENTITY	Estrogen regulates expression of osteoprotegerin and RANKL in human periodontal ligament cells through estrogen receptor beta .
1943752	0	estrogen	10,18	oxytocin	61,69	estrogen	oxytocin	MESH:D004967	5020	Chemical	Gene	hypoglycemia|compound|START_ENTITY hypoglycemia|nmod|levels levels|compound|END_ENTITY	Effect of estrogen or insulin-induced hypoglycemia on plasma oxytocin levels in bulimia and anorexia_nervosa .
2111891	0	estrogen	102,110	oxytocin	3,11	estrogen	oxytocin	MESH:D004967	5020	Chemical	Gene	administered|dobj|START_ENTITY humans|acl|administered plasma|nmod|humans precursor|nmod|plasma precursor|nsubj|END_ENTITY	An oxytocin precursor intermediate circulates in the plasma of humans and rhesus_monkeys administered estrogen .
22761429	0	estrogen	53,61	oxytocin	12,20	estrogen	oxytocin	MESH:D004967	18429(Tax:10090)	Chemical	Gene	action|nmod|START_ENTITY mediates|dobj|action mediates|nsubj|END_ENTITY	Bone marrow oxytocin mediates the anabolic action of estrogen on the skeleton .
8916173	0	estrogen	48,56	oxytocin	24,32	estrogen	oxytocin	MESH:D004967	18429(Tax:10090)	Chemical	Gene	enhanced|nmod|START_ENTITY enhanced|nsubjpass|action action|nmod|END_ENTITY	An anxiolytic action of oxytocin is enhanced by estrogen in the mouse .
9048622	0	estrogen	38,46	oxytocin_receptor	67,84	estrogen	oxytocin receptor	MESH:D004967	25342(Tax:10116)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|gene gene|compound|END_ENTITY	Cloning , novel promoter sequence , and estrogen regulation of a rat oxytocin_receptor gene .
12016147	0	estrogen	20,28	p21	0,3	estrogen	p21	MESH:D004967	12575(Tax:10090)	Chemical	Gene	regression|compound|START_ENTITY END_ENTITY|nmod|regression	p21 , p27 and p53 in estrogen and antiprogestin-induced tumor regression of experimental mouse mammary_ductal_carcinomas .
12393444	0	estrogen	7,15	p21	116,119	estrogen	p21	MESH:D004967	12575(Tax:10090)	Chemical	Gene	chimera|amod|START_ENTITY regulates|nsubj|chimera regulates|nmod|accumulation accumulation|nmod|proteins proteins|amod|END_ENTITY	GATA-2 / estrogen receptor chimera regulates cytokine-dependent growth of hematopoietic cells through accumulation of p21 -LRB- WAF1 -RRB- and p27 -LRB- Kip1 -RRB- proteins .
15755852	0	estrogen	10,18	p21	93,96	estrogen	p21	MESH:D004967	644914	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|growth_arrest growth_arrest|nummod|END_ENTITY	High-dose estrogen and clinical selective estrogen_receptor modulators induce growth_arrest , p21 , and p53 in primate ovarian surface epithelial cells .
20301197	0	estrogen	59,67	p21	37,40	estrogen	p21	MESH:D004967	1026	Chemical	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Estrogen regulated expression of the p21 Waf1/Cip1 gene in estrogen receptor positive human breast_cancer cells .
8420353	0	estrogen	141,149	p21	27,30	estrogen	p21	MESH:D004967	644914	Chemical	Gene	features|nmod|START_ENTITY correlation|nmod|features Expression|dep|correlation Expression|nmod|protein protein|amod|END_ENTITY	Expression of ras oncogene p21 protein in normal and neoplastic ovarian tissues : correlation with histopathologic features and receptors for estrogen , progesterone , and epidermal growth factor .
10207098	0	estrogen	45,53	p23	38,41	estrogen	p23	MESH:D004967	10728	Chemical	Gene	transduction|amod|START_ENTITY END_ENTITY|nmod|transduction	Role for Hsp90-associated cochaperone p23 in estrogen receptor signal transduction .
2278835	0	estrogen	60,68	p29	52,55	estrogen	p29	MESH:D004967	68592(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY purification|dep|receptor purification|nmod|END_ENTITY	Immunoaffinity purification and characterisation of p29 -- an estrogen receptor related protein .
2592625	0	estrogen	17,25	p29	55,58	estrogen	p29	MESH:D004967	25949	Chemical	Gene	protein|amod|START_ENTITY Expression|nmod|protein Expression|appos|END_ENTITY	Expression of an estrogen receptor-associated protein -LRB- p29 -RRB- in epithelial_tumors of the skin .
2741216	0	estrogen	47,55	p29	0,3	estrogen	p29	MESH:D004967	25949	Chemical	Gene	relation|nmod|START_ENTITY protein|dep|relation protein|amod|END_ENTITY	p29 protein in breast_cancer : relation between estrogen and progesterone_receptors .
7540206	0	estrogen	14,22	p29	49,52	estrogen	p29	MESH:D004967	25949	Chemical	Gene	receptor|compound|START_ENTITY Expression|nmod|receptor related|nsubj|Expression related|dobj|protein protein|appos|END_ENTITY	Expression of estrogen receptor related protein -LRB- p29 -RRB- and estradiol binding in human arthritic synovium .
8733275	0	estrogen	78,86	p29	97,100	estrogen	p29	MESH:D004967	25949	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	-LSB- Gallbladder_cancer : immunohistochemical expression of the protein related to estrogen receptor -LRB- p29 -RRB- and of the protein induced by estrogen -LRB- pS2 -RRB- -RSB- .
10617642	0	estrogen	66,74	p38	18,21	estrogen	p38	MESH:D004967	1432	Chemical	Gene	pathway|nmod|START_ENTITY pathway|amod|END_ENTITY	Activation of the p38 mitogen-activated protein kinase pathway by estrogen or by 4-hydroxytamoxifen is coupled to estrogen_receptor-induced apoptosis .
24465521	0	estrogen	78,86	p38b	14,18	estrogen	p38b	MESH:D004967	5600	Chemical	Gene	mediated|nmod|START_ENTITY mediated|nsubj|END_ENTITY	Mitochondrial p38b and manganese_superoxide dismutase interaction mediated by estrogen in cardiomyocytes .
14667141	0	estrogen	44,52	p53	13,16	estrogen	p53	MESH:D004967	7157	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|expression expression|compound|END_ENTITY	Induction of p53 expression and function by estrogen in osteoblasts .
21695979	0	estrogen	34,42	p53	22,25	estrogen	p53	MESH:D004967	7157	Chemical	Gene	receptors|amod|START_ENTITY receptors|dep|END_ENTITY	-LSB- Expression of Ki-67 , p53 , bcl-2 , estrogen receptors alpha in patients with clear_cell_renal_carcinoma and epidermal_growth_factor_receptor mutation -RSB- .
16156894	0	estrogen	77,85	p75NTR	26,32	estrogen	p75NTR	MESH:D004967	24596(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY mediates|dobj|effects mediates|nsubj|END_ENTITY	The neurotrophin receptor p75NTR mediates early anti-inflammatory effects of estrogen in the forebrain of young adult rats .
18662686	0	estrogen	28,36	pS2	51,54	estrogen	pS2	MESH:D004967	21784(Tax:10090)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Chromatin context dominates estrogen regulation of pS2 gene expression .
8733275	0	estrogen	132,140	pS2	142,145	estrogen	pS2	MESH:D004967	338412	Chemical	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Gallbladder_cancer : immunohistochemical expression of the protein related to estrogen receptor -LRB- p29 -RRB- and of the protein induced by estrogen -LRB- pS2 -RRB- -RSB- .
12627043	0	estrogen	10,18	parathyroid_hormone	42,61	estrogen	parathyroid hormone	MESH:D004967	5741	Chemical	Gene	therapy|compound|START_ENTITY therapy|nmod|secretion secretion|amod|END_ENTITY	Effect of estrogen replacement therapy on parathyroid_hormone secretion in elderly postmenopausal women .
3754923	0	estrogen	55,63	parathyroid_hormone	20,39	estrogen	parathyroid hormone	MESH:D004967	5741	Chemical	Gene	START_ENTITY|nsubj|Interaction Interaction|nmod|END_ENTITY	Interaction between parathyroid_hormone and endogenous estrogen in normal women .
8133258	0	estrogen	69,77	parathyroid_hormone-related_peptide	14,49	estrogen	parathyroid hormone-related peptide	MESH:D004967	24695(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of parathyroid_hormone-related_peptide gene expression by estrogen in GH4C1 rat pituitary cells has the pattern of a primary response gene .
9790998	0	estrogen	96,104	parathyroid_hormone-related_protein	14,49	estrogen	parathyroid hormone-related protein	MESH:D004967	5744	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of parathyroid_hormone-related_protein expression in MCF-7 breast_carcinoma cells by estrogen and antiestrogens .
16269913	0	estrogen	23,31	parvalbumin	8,19	estrogen	parvalbumin	MESH:D004967	25269(Tax:10116)	Chemical	Gene	protection|compound|START_ENTITY Role|nmod|protection Role|nmod|END_ENTITY	Role of parvalbumin in estrogen protection from ethanol withdrawal_syndrome .
21411124	0	estrogen	11,19	parvalbumin	46,57	estrogen	parvalbumin	MESH:D004967	25269(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|compound|END_ENTITY	Effects of estrogen via estrogen receptors on parvalbumin levels in cardiac myocytes of ovariectomized rats .
21411124	0	estrogen	24,32	parvalbumin	46,57	estrogen	parvalbumin	MESH:D004967	25269(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY Effects|nmod|receptors Effects|nmod|levels levels|compound|END_ENTITY	Effects of estrogen via estrogen receptors on parvalbumin levels in cardiac myocytes of ovariectomized rats .
17557980	0	estrogen	92,100	peroxisome_proliferator-activated_receptor_alpha	29,77	estrogen	peroxisome proliferator-activated receptor alpha	MESH:D004967	19013(Tax:10090)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|actions actions|nmod|END_ENTITY	Inhibition of the actions of peroxisome_proliferator-activated_receptor_alpha on obesity by estrogen .
17433823	0	estrogen	10,18	phosphatidylinositol-3_kinase	37,66	estrogen	phosphatidylinositol-3 kinase	MESH:D004967	298947(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of estrogen and inhibition of phosphatidylinositol-3_kinase on Akt and FOXO1 in rat uterus .
17194752	0	estrogen	33,41	phosphatidylinositol_3-kinase	56,85	estrogen	phosphatidylinositol 3-kinase	MESH:D004967	5295	Chemical	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Phosphorylation of MNAR promotes estrogen activation of phosphatidylinositol_3-kinase .
21176602	0	estrogen	12,20	phosphofructokinase_muscle-specific_isoform	42,85	estrogen	phosphofructokinase muscle-specific isoform	MESH:D004967	65152(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of estrogen on the expression of phosphofructokinase_muscle-specific_isoform in genioglossus of chronic intermittent hypoxia rats -RSB- .
2633167	0	estrogen	24,32	prodynorphin	67,79	estrogen	prodynorphin	MESH:D004967	29190(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|gene gene|compound|END_ENTITY	Differential effects of estrogen and antiestrogen on expression of prodynorphin gene in the rat hypothalamus and pituitary .
1707724	0	estrogen	60,68	proenkephalin	27,40	estrogen	proenkephalin	MESH:D004967	29237(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Differential regulation of proenkephalin gene expression by estrogen in the ventromedial hypothalamus of male and female rats : implications for the molecular basis of a sexually differentiated behavior .
9221919	0	estrogen	19,27	proenkephalin	56,69	estrogen	proenkephalin	MESH:D004967	29237(Tax:10116)	Chemical	Gene	sensitivity|compound|START_ENTITY Alterations|nmod|sensitivity Alterations|nmod|expression expression|compound|END_ENTITY	Alterations in the estrogen sensitivity of hypothalamic proenkephalin mRNA expression with age and prenatal exposure to alcohol .
12446585	0	estrogen	57,65	progesterone_receptor	88,109	estrogen	progesterone receptor	MESH:D004967	5241	Chemical	Gene	responsiveness|compound|START_ENTITY responsiveness|nmod|gene gene|compound|END_ENTITY	Estrogen receptor alpha and activating protein-1 mediate estrogen responsiveness of the progesterone_receptor gene in MCF-7 breast_cancer cells .
2019267	0	estrogen	31,39	progesterone_receptor	43,64	estrogen	progesterone receptor	MESH:D004967	101098742	Chemical	Gene	Distribution|nmod|START_ENTITY Distribution|nmod|END_ENTITY	Distribution and regulation by estrogen of progesterone_receptor in the hypothalamus of the cat .
2207839	1	estrogen	45,53	progesterone_receptor	92,113	estrogen	progesterone receptor	MESH:D004967	396198(Tax:9031)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|nmod|END_ENTITY	The effect of estrogen and progesterone on the expression of progesterone_receptor .
23211298	0	estrogen	115,123	progesterone_receptor	86,107	estrogen	progesterone receptor	MESH:D004967	25154(Tax:10116)	Chemical	Gene	pathway|compound|START_ENTITY END_ENTITY|nmod|pathway	Additional effects of bisphenol_A and paraben on the induction of calbindin-D -LRB- 9K -RRB- and progesterone_receptor via an estrogen receptor pathway in rat pituitary GH3 cells .
2477493	0	estrogen	11,19	progesterone_receptor	23,44	estrogen	progesterone receptor	MESH:D004967	5241	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|synthesis synthesis|compound|END_ENTITY	Effects of estrogen on progesterone_receptor synthesis during endometrial cell culture .
26048717	0	estrogen	10,18	prohibitin	36,46	estrogen	prohibitin	MESH:D004967	25344(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	Effect of estrogen on expression of prohibitin in white_adipose_tissue and liver of diet-induced obese rats .
10627290	0	estrogen	130,138	prolactin	57,66	estrogen	prolactin	MESH:D004967	24683(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY modulate|nmod|receptors modulate|dobj|release release|compound|END_ENTITY	Antibodies to the estrogen receptor-alpha modulate rapid prolactin release from rat pituitary tumor cells through plasma membrane estrogen receptors .
10627290	0	estrogen	18,26	prolactin	57,66	estrogen	prolactin	MESH:D004967	24683(Tax:10116)	Chemical	Gene	receptor-alpha|compound|START_ENTITY Antibodies|nmod|receptor-alpha modulate|nsubj|Antibodies modulate|dobj|release release|compound|END_ENTITY	Antibodies to the estrogen receptor-alpha modulate rapid prolactin release from rat pituitary tumor cells through plasma membrane estrogen receptors .
10736185	0	estrogen	41,49	prolactin	91,100	estrogen	prolactin	MESH:D004967	24683(Tax:10116)	Chemical	Gene	half-sites|amod|START_ENTITY interaction|nmod|half-sites interaction|nmod|gene gene|compound|END_ENTITY	Estrogen_receptor_alpha interaction with estrogen response element half-sites from the rat prolactin gene .
11344580	0	estrogen	39,47	prolactin	16,25	estrogen	prolactin	MESH:D004967	5617	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Augmentation Augmentation|nmod|END_ENTITY	Augmentation of prolactin secretion by estrogen in hypogonadal women .
1153405	0	estrogen	48,56	prolactin	6,15	estrogen	prolactin	MESH:D004967	24683(Tax:10116)	Chemical	Gene	stimulation|compound|START_ENTITY rats|nmod|stimulation levels|nmod|rats levels|compound|END_ENTITY	Serum prolactin levels of rats under continuous estrogen stimulation and 2 Br-alpha-ergocryptine -LRB- CB-154 -RRB- injection .
122417	0	estrogen	51,59	prolactin	38,47	estrogen	prolactin	MESH:D004967	5617	Chemical	Gene	primed|dep|START_ENTITY women|amod|primed induced|nmod|women induced|dobj|release release|nmod|END_ENTITY	Progesterone induced acute release of prolactin in estrogen primed ovariectomized women .
12259440	0	estrogen	11,19	prolactin	55,64	estrogen	prolactin	MESH:D004967	5617	Chemical	Gene	modulates|compound|START_ENTITY phenothiazine|nsubj|modulates phenothiazine|dobj|secretion secretion|compound|END_ENTITY	Endogenous estrogen modulates phenothiazine stimulated prolactin secretion .
12259440	1	estrogen	119,127	prolactin	164,173	estrogen	prolactin	MESH:D004967	5617	Chemical	Gene	concentrations|compound|START_ENTITY concentrations|nmod|regulation regulation|nmod|secretion secretion|compound|END_ENTITY	The possible role of fluctuations in serum estrogen concentrations in the regulation of prolactin secretion was investigated by comparing phenothiazine-stimulated prolactin secretion in normal women during the early follicular phase and the late follicular phase of the menstrual cycle .
12578974	0	estrogen	64,72	prolactin	28,37	estrogen	prolactin	MESH:D004967	24683(Tax:10116)	Chemical	Gene	modulated|nmod|START_ENTITY modulated|nsubjpass|effect effect|nmod|anandamide anandamide|nmod|secretion secretion|compound|END_ENTITY	The effect of anandamide on prolactin secretion is modulated by estrogen .
1263282	0	estrogen	37,45	prolactin	59,68	estrogen	prolactin	MESH:D004967	24683(Tax:10116)	Chemical	Gene	Studies|nmod|START_ENTITY Studies|nmod|END_ENTITY	Studies on metabolism and effects of estrogen on pituitary prolactin and LH secretion .
12668878	0	estrogen	11,19	prolactin	101,110	estrogen	prolactin	MESH:D004967	24683(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY Changes|nmod|expression Changes|nmod|hypothalamic_dopaminergic_neurons hypothalamic_dopaminergic_neurons|nmod|surge surge|compound|END_ENTITY	Changes in estrogen receptor-alpha expression in hypothalamic_dopaminergic_neurons during proestrous prolactin surge .
12679088	0	estrogen	25,33	prolactin	71,80	estrogen	prolactin	MESH:D004967	5617	Chemical	Gene	intestinal|compound|START_ENTITY action|nmod|intestinal peptide|nsubj|action peptide|nmod|secretion secretion|compound|END_ENTITY	The regulatory action of estrogen and vasoactive intestinal peptide on prolactin secretion in sea bream -LRB- Sparus aurata , L. -RRB- .
12697713	0	estrogen	73,81	prolactin	12,21	estrogen	prolactin	MESH:D004967	24683(Tax:10116)	Chemical	Gene	response|nmod|START_ENTITY role|nmod|response role|nmod|END_ENTITY	The role of prolactin in the prostatic inflammatory response to neonatal estrogen .
1323801	0	estrogen	60,68	prolactin	14,23	estrogen	prolactin	MESH:D004967	24683(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY mediates|dobj|effects mediates|nsubj|END_ENTITY	Evidence that prolactin mediates the stimulatory effects of estrogen on tuberoinfundibular dopamine neurons in female rats .
15026085	0	estrogen	69,77	prolactin	17,26	estrogen	prolactin	MESH:D004967	5617	Chemical	Gene	alpha|amod|START_ENTITY induces|dobj|alpha induces|nsubj|END_ENTITY	Endogenous human prolactin and not exogenous human prolactin induces estrogen receptor alpha and prolactin_receptor expression and increases estrogen responsiveness in breast_cancer cells .
15993477	0	estrogen	11,19	prolactin	87,96	estrogen	prolactin	MESH:D004967	24683(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|acl|evaluated evaluated|advmod|as as|nmod:npmod|cells cells|nummod|END_ENTITY	Effects of estrogen and tamoxifen on the ultrastructural characteristics of female rat prolactin cells as evaluated by immunogold technique .
16164119	0	estrogen	55,63	prolactin	10,19	estrogen	prolactin	MESH:D004967	24683(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY inhibition|nmod|production inhibition|compound|END_ENTITY	-LSB- Sites of prolactin inhibition on gonadotropin-induced estrogen production in cultured rat granulosa cells -RSB- .
17272926	0	estrogen	14,22	prolactin	45,54	estrogen	prolactin	MESH:D004967	19109(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of estrogen on phosphorylation of prolactin in the mouse pituitary gland .
1731525	0	estrogen	15,23	prolactin	27,36	estrogen	prolactin	MESH:D004967	24683(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|methylation methylation|compound|END_ENTITY	The effects of estrogen on prolactin gene methylation in normal and neoplastic rat pituitary tissues .
1761162	0	estrogen	55,63	prolactin	67,76	estrogen	prolactin	MESH:D004967	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	Inhibitory effects of serum and stimulatory effects of estrogen on prolactin mRNA levels in GH3 rat pituitary tumor cells .
19210377	0	estrogen	11,19	prolactin	89,98	estrogen	prolactin	MESH:D004967	24683(Tax:10116)	Chemical	Gene	transplants|compound|START_ENTITY Effects|nmod|transplants Effects|nmod|responsiveness responsiveness|nmod|END_ENTITY	Effects of estrogen and ectopic pituitary transplants on the responsiveness of pituitary prolactin release to luteinizing_hormone-releasing_hormone and dopamine .
19637056	0	estrogen	31,39	prolactin	53,62	estrogen	prolactin	MESH:D004967	5617	Chemical	Gene	treatment|compound|START_ENTITY Effect|nmod|treatment Effect|nmod|levels levels|compound|END_ENTITY	Effect of long-term , high-dose estrogen treatment on prolactin levels : a retrospective analysis .
1968222	0	estrogen	73,81	prolactin	14,23	estrogen	prolactin	MESH:D004967	24683(Tax:10116)	Chemical	Gene	interactions|nmod|START_ENTITY Regulation|dep|interactions Regulation|nmod|transcription transcription|compound|END_ENTITY	Regulation of prolactin gene transcription in vivo : interactions between estrogen , pimozide , and alpha-ergocryptine .
1972060	0	estrogen	87,95	prolactin	17,26	estrogen	prolactin	MESH:D004967	24683(Tax:10116)	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|levels levels|compound|END_ENTITY	Increased plasma prolactin levels in ovariectomized thyroidectomized rats treated with estrogen .
20198387	0	estrogen	89,97	prolactin	66,75	estrogen	prolactin	MESH:D004967	19109(Tax:10090)	Chemical	Gene	proliferation|compound|START_ENTITY synthesis|nmod|proliferation synthesis|compound|END_ENTITY	Involvement of insulin-like_growth_factor-I for the regulation of prolactin synthesis by estrogen and postnatal proliferation of lactotrophs in the mouse anterior pituitary .
2082192	0	estrogen	54,62	prolactin	89,98	estrogen	prolactin	MESH:D004967	24683(Tax:10116)	Chemical	Gene	responsiveness|compound|START_ENTITY responsiveness|nmod|gene gene|compound|END_ENTITY	Both Pit-1 and the estrogen receptor are required for estrogen responsiveness of the rat prolactin gene .
22354782	0	estrogen	80,88	prolactin	28,37	estrogen	prolactin	MESH:D004967	24683(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY induced|nmod|receptors induced|nsubj|modulates modulates|dep|secretion secretion|compound|END_ENTITY	17b-Estradiol modulates the prolactin secretion induced by TRH through membrane estrogen receptors via PI3K/Akt in female rat anterior pituitary cell culture .
2540428	0	estrogen	30,38	prolactin	51,60	estrogen	prolactin	MESH:D004967	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|elements elements|compound|END_ENTITY	Transcriptional regulation by estrogen of episomal prolactin gene regulatory elements .
2738308	0	estrogen	57,65	prolactin	6,15	estrogen	prolactin	MESH:D004967	5617	Chemical	Gene	use|compound|START_ENTITY values|nmod|use END_ENTITY|dep|values	Serum prolactin and aging : basal values and changes with estrogen use and hypothyroidism .
2883661	0	estrogen	90,98	prolactin	46,55	estrogen	prolactin	MESH:D004967	24683(Tax:10116)	Chemical	Gene	pretreated|nmod|START_ENTITY pretreated|nsubj|effects effects|nmod|analogs analogs|nmod|secretion secretion|compound|END_ENTITY	Inhibitory effects of somatostatin analogs on prolactin secretion in rats pretreated with estrogen or haloperidol .
3224819	0	estrogen	88,96	prolactin	24,33	estrogen	prolactin	MESH:D004967	24683(Tax:10116)	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|elements elements|nmod|rat rat|acl|END_ENTITY	Two elements of the rat prolactin 5 ' flanking region are required for its regulation by estrogen and glucocorticoids .
3398840	0	estrogen	23,31	prolactin	121,130	estrogen	prolactin	MESH:D004967	24683(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY domain|nmod|receptor confers|nsubj|domain confers|dobj|activation activation|nmod|gene gene|compound|END_ENTITY	A single domain of the estrogen receptor confers deoxyribonucleic acid binding and transcriptional activation of the rat prolactin gene .
3507885	0	estrogen	55,63	prolactin	73,82	estrogen	prolactin	MESH:D004967	100034034(Tax:9796)	Chemical	Gene	immunization|nmod|START_ENTITY Effects|nmod|immunization Effects|nmod|concentrations concentrations|compound|END_ENTITY	Effects of age , season and active immunization against estrogen on serum prolactin concentrations in stallions .
3517670	0	estrogen	10,18	prolactin	22,31	estrogen	prolactin	MESH:D004967	24683(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|mRNA mRNA|compound|END_ENTITY	Effect of estrogen on prolactin mRNA in the rat pituitary .
4368243	0	estrogen	15,23	prolactin	65,74	estrogen	prolactin	MESH:D004967	24683(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY Regulation|nmod|receptors Regulation|dep|action action|nmod|END_ENTITY	-LSB- Regulation of estrogen `` receptors '' in mammary_tumors : action of prolactin in vivo -RSB- .
6089499	0	estrogen	53,61	prolactin	11,20	estrogen	prolactin	MESH:D004967	24683(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY Effects|nmod|receptors Effects|nmod|END_ENTITY	Effects of prolactin , bromocriptine and sulpiride on estrogen and lactogenic receptors in the rat adrenal gland .
6445525	0	estrogen	47,55	prolactin	69,78	estrogen	prolactin	MESH:D004967	5617	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	-LSB- The effect of methergoline and of a synthetic estrogen on plasmatic prolactin levels and on postpartum lactation -RSB- .
6539847	0	estrogen	14,22	prolactin	53,62	estrogen	prolactin	MESH:D004967	24683(Tax:10116)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|secretion secretion|compound|END_ENTITY	Inhibition by estrogen of autofeedback regulation of prolactin secretion .
6628980	0	estrogen	11,19	prolactin	46,55	estrogen	prolactin	MESH:D004967	100303694(Tax:9103)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of estrogen and progesterone on serum prolactin and luteinizing hormone levels in ovariectomized turkeys -LRB- Meleagris_gallopavo -RRB- .
6682047	0	estrogen	10,18	prolactin	65,74	estrogen	prolactin	MESH:D004967	24683(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY administration|nmod|induction induction|nmod|surge surge|compound|END_ENTITY	Effect of estrogen administration on the induction of the plasma prolactin afternoon surge and on anterior pituitary prolactin concentration extracted at different pHs .
6694532	0	estrogen	95,103	prolactin	58,67	estrogen	prolactin	MESH:D004967	24683(Tax:10116)	Chemical	Gene	response|nmod|START_ENTITY differently|nmod|response release|advmod|differently release|dobj|END_ENTITY	Ovariectomized Sprague-Dawley and Long-Evans rats release prolactin differently in response to estrogen .
6745162	0	estrogen	22,30	prolactin	34,43	estrogen	prolactin	MESH:D004967	280901(Tax:9913)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Stimulatory effect of estrogen on prolactin secretion from primate pituitary cells cultured on extracellular matrix and in serum-free medium .
6769662	0	estrogen	10,18	prolactin	71,80	estrogen	prolactin	MESH:D004967	707052(Tax:9544)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|release release|nmod|END_ENTITY	Effect of estrogen on thyrotropin-releasing_hormone-induced release of prolactin in intact , ovariectomized , and stalk-sectioned female rhesus_monkeys .
7124858	0	estrogen	75,83	prolactin	21,30	estrogen	prolactin	MESH:D004967	5617	Chemical	Gene	receiving|dobj|START_ENTITY pattern|acl|receiving pattern|nmod|secretion secretion|compound|END_ENTITY	Circadian pattern of prolactin secretion in postmenopausal women receiving estrogen with or without progestin .
7449733	0	estrogen	8,16	prolactin	48,57	estrogen	prolactin	MESH:D004967	24683(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|control control|nmod|secretion secretion|compound|END_ENTITY	Role of estrogen in the dopaminergic control of prolactin secretion .
7584558	0	estrogen	122,130	prolactin	47,56	estrogen	prolactin	MESH:D004967	24683(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY mRNAs|nmod|treatment mRNAs|nsubj|Changes Changes|nmod|distribution distribution|nmod|hormone hormone|compound|END_ENTITY	Changes in the ultrastructural distribution of prolactin and growth hormone mRNAs in pituitary cells of female rats after estrogen and bromocriptine treatment , studied using in situ hybridization with biotinylated oligonucleotide probes .
7708061	0	estrogen	40,48	prolactin	71,80	estrogen	prolactin	MESH:D004967	24683(Tax:10116)	Chemical	Gene	responsiveness|compound|START_ENTITY responsiveness|nmod|gene gene|compound|END_ENTITY	Multiple Pit-1-binding sites facilitate estrogen responsiveness of the prolactin gene .
7725821	0	estrogen	84,92	prolactin	22,31	estrogen	prolactin	MESH:D004967	24683(Tax:10116)	Chemical	Gene	vitro|nmod|START_ENTITY treatment|amod|vitro secretion|nmod|treatment secretion|nsubj|changes changes|nmod|END_ENTITY	Reciprocal changes in prolactin and growth_hormone secretion in vitro after in vivo estrogen treatment .
7784905	0	estrogen	53,61	prolactin	11,20	estrogen	prolactin	MESH:D004967	19109(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of prolactin on gonadotropin-induced ovarian estrogen and progesterone production in mouse -RSB- .
8424109	0	estrogen	11,19	prolactin	51,60	estrogen	prolactin	MESH:D004967	24683(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|mRNA mRNA|compound|END_ENTITY	Effects of estrogen and epidermal_growth_factor on prolactin and Pit-1 mRNA in GH3 cells .
862764	0	estrogen	27,35	prolactin	56,65	estrogen	prolactin	MESH:D004967	24683(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY treatment|nmod|levels levels|compound|END_ENTITY	The influence of long term estrogen treatment on plasma prolactin levels induced by ether anesthesia in ovariectomized rats .
8674822	0	estrogen	12,20	prolactin	107,116	estrogen	prolactin	MESH:D004967	24683(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY role|nmod|receptor role|nmod|conformation conformation|nmod|region region|nmod|gene gene|compound|END_ENTITY	The role of estrogen receptor in modulation of chromatin conformation in the 5 ' flanking region of the rat prolactin gene .
8736119	0	estrogen	10,18	prolactin	39,48	estrogen	prolactin	MESH:D004967	24683(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|amod|END_ENTITY	Effect of estrogen and neuroleptics on prolactin secretion and immunoreactive prolactin cells .
881623	0	estrogen	11,19	prolactin	23,32	estrogen	prolactin	MESH:D004967	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|dopaminergic dopaminergic|compound|END_ENTITY	Effects of estrogen on prolactin and tuberoinfundibular dopaminergic neurons .
9678073	0	estrogen	46,54	prolactin	15,24	estrogen	prolactin	MESH:D004967	5617	Chemical	Gene	pills|compound|START_ENTITY serum|nmod|pills serum|dobj|level level|compound|END_ENTITY	Elevated serum prolactin level with high-dose estrogen contraceptive pills .
977726	0	estrogen	11,19	prolactin	55,64	estrogen	prolactin	MESH:D004967	5617	Chemical	Gene	modulates|compound|START_ENTITY phenothiazine|nsubj|modulates phenothiazine|dobj|secretion secretion|compound|END_ENTITY	Endogenous estrogen modulates phenothiazine stimulated prolactin secretion .
984083	0	estrogen	26,34	prolactin	38,47	estrogen	prolactin	MESH:D004967	5617	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|release release|compound|END_ENTITY	Effects of large doses of estrogen on prolactin and growth hormone release .
1714969	0	estrogen	26,34	prostate_specific_antigen	106,131	estrogen	prostate specific antigen	MESH:D004967	354	Chemical	Gene	Effect|nmod|START_ENTITY Effect|acl|END_ENTITY	Effect of the addition of estrogen to medical castration on prostatic size , symptoms , histology and serum prostate_specific_antigen in 4 men with benign_prostatic_hypertrophy .
22291441	0	estrogen	94,102	protease-activated_receptor_1	20,49	estrogen	protease-activated receptor 1	MESH:D004967	2149	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of human protease-activated_receptor_1 -LRB- hPar1 -RRB- gene expression in breast_cancer by estrogen .
12266190	0	estrogen	57,65	renin	16,21	estrogen	renin	MESH:D004967	5972	Chemical	Gene	pill|compound|START_ENTITY using|dobj|pill Study|acl|using Study|nmod|activity activity|compound|END_ENTITY	Study of plasma renin activity in Indian women using low estrogen combination pill as contraceptive -LSB- abstract -RSB- .
7018189	0	estrogen	112,120	renin	18,23	estrogen	renin	MESH:D004967	5972	Chemical	Gene	treatment|nmod|START_ENTITY END_ENTITY|nmod|treatment	Changes in plasma renin concentration , activity and substrate after twentyeight days ' treatment with micronized estrogen , ethinylestradiol and norethisterone-acetate in postmenopausal women .
25827459	0	estrogen	62,70	sclerostin	10,20	estrogen	sclerostin	MESH:D004967	50964	Chemical	Gene	remnant|acl|START_ENTITY levels|nmod|remnant levels|compound|END_ENTITY	Increased sclerostin levels after further ablation of remnant estrogen by aromatase inhibitors .
15823831	0	estrogen	54,62	sex_hormone_binding_globulin	99,127	estrogen	sex hormone binding globulin	MESH:D004967	6462	Chemical	Gene	START_ENTITY|nmod|therapy therapy|nmod|levels levels|compound|END_ENTITY	Different effects of tibolone and continuous combined estrogen plus progestogen hormone therapy on sex_hormone_binding_globulin and free testosterone levels -- an association with mammographic density .
21184767	0	estrogen	48,56	sex_hormone_binding_globulin	103,131	estrogen	sex hormone binding globulin	MESH:D004967	6462	Chemical	Gene	complexes|nmod|START_ENTITY Arene|dep|complexes Arene|dep|interaction interaction|nmod|activity activity|compound|END_ENTITY	-LRB- Arene -RRB- Cl ___ Ru -LRB- II -RRB- complexes with N-coordinated estrogen and androgen isonicotinates : interaction with sex_hormone_binding_globulin and anticancer activity .
25472263	0	estrogen	172,180	snail	4,9	estrogen	snail	MESH:D004967	6615	Chemical	Gene	receptors|compound|START_ENTITY expressing|dobj|receptors cells|acl|expressing appeared|nmod|cells appeared|nsubj|END_ENTITY	215 snail and slug , markers of epithelial mesenchymal transition , appeared to be altered by alkyl-phenols , bisphenol_a and nonyl-phenol , in ovarian_cancer cells expressing estrogen receptors .
9121431	0	estrogen	71,79	steroid_receptor_coactivator_1	33,63	estrogen	steroid receptor coactivator 1	MESH:D004967	17977(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	AF-2 activity and recruitment of steroid_receptor_coactivator_1 to the estrogen receptor depend on a lysine residue conserved in nuclear receptors .
2965775	0	estrogen	11,19	sulfatase	50,59	estrogen	sulfatase	MESH:D004967	347527	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|amod|END_ENTITY	Effects of estrogen and growth_hormone on steroid sulfatase activity and estrogen binding in rat liver .
18389986	0	estrogen	80,88	synaptophysin	51,64	estrogen	synaptophysin	MESH:D004967	24804(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY expression|nmod|receptor expression|compound|END_ENTITY	Pueraria mirifica , phytoestrogen-induced change in synaptophysin expression via estrogen receptor in rat hippocampal neuron .
2473935	0	estrogen	20,28	tgb	32,35	estrogen	tgb	MESH:D004967	5473	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	In vitro effects of estrogen on tgb and c-myc gene expression in normal and neoplastic human thyroids .
1352334	0	estrogen	10,18	thyroglobulin	41,54	estrogen	thyroglobulin	MESH:D004967	7038	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of estrogen on the serum level of thyroglobulin .
1791840	0	estrogen	14,22	transforming_growth_factor_alpha	61,93	estrogen	transforming growth factor alpha	MESH:D004967	7124	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|dep|region region|nmod|gene gene|compound|END_ENTITY	Regulation by estrogen through the 5 ' - flanking region of the transforming_growth_factor_alpha gene .
2484711	0	estrogen	97,105	transforming_growth_factor_alpha	14,46	estrogen	transforming growth factor alpha	MESH:D004967	24827(Tax:10116)	Chemical	Gene	induction|compound|START_ENTITY Expression|dep|induction Expression|nmod|END_ENTITY	Expression of transforming_growth_factor_alpha -LRB- TGF_alpha -RRB- in differentiated rat mammary_tumors : estrogen induction of TGF_alpha production .
3047554	0	estrogen	124,132	transforming_growth_factor_alpha	14,46	estrogen	transforming growth factor alpha	MESH:D004967	7124	Chemical	Gene	regulation|nmod|START_ENTITY Expression|dep|regulation Expression|nmod|END_ENTITY	Expression of transforming_growth_factor_alpha and its messenger ribonucleic acid in human breast_cancer : its regulation by estrogen and its possible functional significance .
9588692	0	estrogen	10,18	transforming_growth_factor_alpha	35,67	estrogen	transforming growth factor alpha	MESH:D004967	613031(Tax:9544)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of estrogen on hypothalamic transforming_growth_factor_alpha and gonadotropin-releasing hormone gene expression in the female rhesus_monkey .
11000518	0	estrogen	23,31	transthyretin	35,48	estrogen	transthyretin	MESH:D004967	7276	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|compound|END_ENTITY	Contrasting effects of estrogen on transthyretin and vitellogenin expression in males of the marine fish , Sparus aurata .
23860318	0	estrogen	9,17	transthyretin	68,81	estrogen	transthyretin	MESH:D004967	7276	Chemical	Gene	responsive|amod|START_ENTITY element|amod|responsive element|advmod|upstream upstream|nmod:npmod|site site|nmod|gene gene|compound|END_ENTITY	A distal estrogen responsive element upstream the cap site of human transthyretin gene is an enhancer-like element upon ERa and/or ERb transactivation .
24033289	0	estrogen	72,80	tryptophan_hydroxylase-2	36,60	estrogen	tryptophan hydroxylase-2	MESH:D004967	121278	Chemical	Gene	element|amod|START_ENTITY regulates|nmod|element regulates|dobj|END_ENTITY	Estrogen receptor-b regulates human tryptophan_hydroxylase-2 through an estrogen response element in the 5 ' untranslated region .
19225428	0	estrogen	93,101	tumor_necrosis_factor	33,54	estrogen	tumor necrosis factor	MESH:D004967	7124	Chemical	Gene	system|nmod|START_ENTITY system|compound|END_ENTITY	Relationship between circulating tumor_necrosis_factor system and bone mass before and after estrogen plus progestogen therapy .
18006630	0	estrogen	44,52	tumor_necrosis_factor-alpha	71,98	estrogen	tumor necrosis factor-alpha	MESH:D004967	7124	Chemical	Gene	regulation|nmod|START_ENTITY regulation|dep|convergence convergence|nmod|signaling signaling|amod|END_ENTITY	Human prolactin gene promoter regulation by estrogen : convergence with tumor_necrosis_factor-alpha signaling .
18957495	0	estrogen	41,49	tumor_necrosis_factor-alpha	10,37	estrogen	tumor necrosis factor-alpha	MESH:D004967	7124	Chemical	Gene	metabolism|amod|START_ENTITY END_ENTITY|nmod|metabolism	Effect of tumor_necrosis_factor-alpha on estrogen metabolism and endometrial cells : potential physiological and pathological relevance .
12225877	0	estrogen	80,88	tyrosine_hydroxylase	37,57	estrogen	tyrosine hydroxylase	MESH:D004967	21823(Tax:10090)	Chemical	Gene	transcription|nmod|START_ENTITY transcription|nsubj|differences differences|nmod|regulation regulation|nmod|gene gene|amod|END_ENTITY	Sex differences in the regulation of tyrosine_hydroxylase gene transcription by estrogen in the locus coeruleus of TH9-LacZ transgenic_mice .
15223360	0	estrogen	77,85	tyrosine_hydroxylase	12,32	estrogen	tyrosine hydroxylase	MESH:D004967	25085(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Response of tyrosine_hydroxylase and GTP_cyclohydrolase_I gene expression to estrogen in brain catecholaminergic regions varies with mode of administration .
15935066	0	estrogen	86,94	tyrosine_hydroxylase	30,50	estrogen	tyrosine hydroxylase	MESH:D004967	25085(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY effects|nmod|receptors regulation|dep|effects regulation|nmod|END_ENTITY	Transcriptional regulation of tyrosine_hydroxylase by estrogen : opposite effects with estrogen receptors alpha and beta and interactions with cyclic_AMP .
6127206	0	estrogen	13,21	tyrosine_hydroxylase	131,151	estrogen	tyrosine hydroxylase	MESH:D004967	25085(Tax:10116)	Chemical	Gene	formed|nsubjpass|START_ENTITY formed|nmod|tissue tissue|nmod|END_ENTITY	The catechol estrogen , 2-hydroxyestradiol-17 alpha , is formed from estradiol-17 alpha by hypothalamic tissue in vitro and inhibits tyrosine_hydroxylase .
8616826	0	estrogen	76,84	urokinase-type_plasminogen_activator	36,72	estrogen	urokinase-type plasminogen activator	MESH:D004967	5328	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	Invasive capacity and regulation of urokinase-type_plasminogen_activator in estrogen receptor -LRB- ER -RRB- - negative MDA-MB-231 human breast_cancer cells , and a transfectant -LRB- S30 -RRB- stably expressing ER .
10866309	0	estrogen	29,37	vascular_endothelial_growth_factor	108,142	estrogen	vascular endothelial growth factor	MESH:D004967	7422	Chemical	Gene	elements|amod|START_ENTITY Identification|nmod|elements Identification|nmod|END_ENTITY	Identification of functional estrogen response elements in the gene coding for the potent angiogenic factor vascular_endothelial_growth_factor .
10995484	0	estrogen	78,86	vascular_endothelial_growth_factor	14,48	estrogen	vascular endothelial growth factor	MESH:D004967	7422	Chemical	Gene	receptors|compound|START_ENTITY transcription|nmod|receptors transcription|nsubj|Regulation Regulation|nmod|gene gene|compound|END_ENTITY	Regulation of vascular_endothelial_growth_factor -LRB- VEGF -RRB- gene transcription by estrogen receptors alpha and beta .
11380293	0	estrogen	76,84	vascular_endothelial_growth_factor	17,51	estrogen	vascular endothelial growth factor	MESH:D004967	7422	Chemical	Gene	replacement|compound|START_ENTITY initiation|nmod|replacement END_ENTITY|dobj|initiation	Changes in serum vascular_endothelial_growth_factor following initiation of estrogen replacement after hysterectomy and oophorectomy .
12208749	0	estrogen	144,152	vascular_endothelial_growth_factor	30,64	estrogen	vascular endothelial growth factor	MESH:D004967	7422	Chemical	Gene	receptors|compound|START_ENTITY interplay|nmod|receptors regulation|dep|interplay regulation|nmod|END_ENTITY	Transcriptional regulation of vascular_endothelial_growth_factor by estradiol and tamoxifen in breast_cancer cells : a complex interplay between estrogen receptors alpha and beta .
15173272	0	estrogen	47,55	vascular_endothelial_growth_factor	68,102	estrogen	vascular endothelial growth factor	MESH:D004967	7422	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	An angiogenic switch in breast_cancer involves estrogen and soluble vascular_endothelial_growth_factor receptor 1 .
15736439	0	estrogen	10,18	vascular_endothelial_growth_factor	95,129	estrogen	vascular endothelial growth factor	MESH:D004967	7422	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|regulation regulation|nmod|END_ENTITY	Effect of estrogen , tamoxifen and epidermal_growth_factor on the transcriptional regulation of vascular_endothelial_growth_factor in breast_cancer cells .
15774498	0	estrogen	122,130	vascular_endothelial_growth_factor	184,218	estrogen	vascular endothelial growth factor	MESH:D004967	83785(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY recruitment|nmod|receptor recruitment|dep|factor factor|nmod|promoter promoter|compound|END_ENTITY	Chromatin immunoprecipitation analysis of gene expression in the rat uterus in vivo : estrogen-induced recruitment of both estrogen receptor alpha and hypoxia-inducible factor 1 to the vascular_endothelial_growth_factor promoter .
15956714	0	estrogen	119,127	vascular_endothelial_growth_factor	51,85	estrogen	vascular endothelial growth factor	MESH:D004967	7422	Chemical	Gene	insight|nmod|START_ENTITY insight|nmod|regulation regulation|nmod|expression expression|compound|END_ENTITY	New insight into the transcriptional regulation of vascular_endothelial_growth_factor expression in the endometrium by estrogen and relaxin .
16168402	0	estrogen	66,74	vascular_endothelial_growth_factor	15,49	estrogen	vascular endothelial growth factor	MESH:D004967	83785(Tax:10116)	Chemical	Gene	therapy|compound|START_ENTITY increased|nmod|therapy increased|nsubjpass|level level|nmod|END_ENTITY	Serum level of vascular_endothelial_growth_factor is increased by estrogen replacement therapy in normotensive and DOCA-Salt hypertensive ovariectomized rats .
18318810	0	estrogen	117,125	vascular_endothelial_growth_factor	129,163	estrogen	vascular endothelial growth factor	MESH:D004967	7422	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Differing responses of human follicular and nonfollicular scalp cells in an in vitro wound healing assay : effects of estrogen on vascular_endothelial_growth_factor secretion .
20017619	0	estrogen	143,151	vascular_endothelial_growth_factor	15,49	estrogen	vascular endothelial growth factor	MESH:D004967	83785(Tax:10116)	Chemical	Gene	modulators|compound|START_ENTITY upregulated|nmod|modulators upregulated|nsubjpass|Expressions Expressions|nmod|END_ENTITY	Expressions of vascular_endothelial_growth_factor and nitric_oxide_synthase_III in the thyroid gland of ovariectomized rats are upregulated by estrogen and selective estrogen receptor modulators .
20017619	0	estrogen	166,174	vascular_endothelial_growth_factor	15,49	estrogen	vascular endothelial growth factor	MESH:D004967	83785(Tax:10116)	Chemical	Gene	modulators|compound|START_ENTITY upregulated|nmod|modulators upregulated|nsubjpass|Expressions Expressions|nmod|END_ENTITY	Expressions of vascular_endothelial_growth_factor and nitric_oxide_synthase_III in the thyroid gland of ovariectomized rats are upregulated by estrogen and selective estrogen receptor modulators .
21180259	0	estrogen	11,19	vascular_endothelial_growth_factor	43,77	estrogen	vascular endothelial growth factor	MESH:D004967	83785(Tax:10116)	Chemical	Gene	therapy|compound|START_ENTITY therapy|nmod|expression expression|compound|END_ENTITY	Effects of estrogen replacement therapy on vascular_endothelial_growth_factor expression in choroidal_and_retinal_vasculature .
9461033	0	estrogen	111,119	vascular_endothelial_growth_factor	47,81	estrogen	vascular endothelial growth factor	MESH:D004967	83785(Tax:10116)	Chemical	Gene	activity|compound|START_ENTITY expression|nmod|activity expression|compound|END_ENTITY	Triphenylethylene antiestrogens induce uterine vascular_endothelial_growth_factor expression via their partial estrogen agonist activity .
2378910	0	estrogen	11,19	very-low-density_lipoprotein	23,51	estrogen	very-low-density lipoprotein	MESH:D004967	396154(Tax:9031)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|metabolism metabolism|amod|END_ENTITY	Effects of estrogen on very-low-density_lipoprotein triacylglycerol metabolism in chicks .
19476621	0	estrogen	128,136	vimentin	147,155	estrogen	vimentin	MESH:D004967	7431	Chemical	Gene	antigen|amod|START_ENTITY antigen|compound|END_ENTITY	Progesterone_receptor does not improve the performance and test effectiveness of the conventional 3-marker panel , consisting of estrogen receptor , vimentin and carcinoembryonic antigen in distinguishing between primary endocervical and endometrial_adenocarcinomas in a tissue microarray extension study .
10321906	0	estrogen	41,49	vitamin_D_receptor	18,36	estrogen	vitamin D receptor	MESH:D004967	22337(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	Expression of the vitamin_D_receptor , of estrogen and thyroid_hormone receptor alpha - and beta-isoforms , and of the androgen_receptor in cultures of native mouse bone marrow and of stromal/osteoblastic cells .
17556531	0	estrogen	15,23	vitamin_D_receptor	105,123	estrogen	vitamin D receptor	MESH:D004967	7421	Chemical	Gene	beta|compound|START_ENTITY Association|nmod|beta Association|dep|implication implication|nmod|control control|nmod|END_ENTITY	Association of estrogen receptor beta with plasma-membrane caveola components : implication in control of vitamin_D_receptor .
267932	0	estrogen	14,22	vitellogenin	30,42	estrogen	vitellogenin	MESH:D004967	378512(Tax:8355)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|gene gene|compound|END_ENTITY	Regulation by estrogen of the vitellogenin gene .
3634868	0	estrogen	13,21	vitellogenin	44,56	estrogen	vitellogenin	MESH:D004967	424533(Tax:9031)	Chemical	Gene	responsiveness|compound|START_ENTITY responsiveness|nmod|END_ENTITY	Differential estrogen responsiveness of the vitellogenin and apo very low density lipoprotein II genes in the rooster liver .
3838520	0	estrogen	11,19	vitellogenin	33,45	estrogen	vitellogenin	MESH:D004967	378512(Tax:8355)	Chemical	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	Coordinate estrogen induction of vitellogenin and a small serum protein mRNA in Xenopus_laevis liver .
8843410	0	estrogen	71,79	vitellogenin_II	12,27	estrogen	vitellogenin II	MESH:D004967	424533(Tax:9031)	Chemical	Gene	unit|compound|START_ENTITY flanked|nmod|unit flanked|nsubjpass|gene gene|compound|END_ENTITY	The chicken vitellogenin_II gene is flanked by a GATA_factor-dependent estrogen response unit .
25240148	2	estrogen	390,398	women	383,388	estrogen	b2-AR	MESH:D004967	154	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	In women , estrogen modulates immune responses during menstrual cycles , and in aging and age-associated diseases .
22467880	0	estrogen	112,120	zinc_finger_protein_131	53,76	estrogen	zinc finger protein 131	MESH:D004967	7690	Chemical	Gene	potentiates|nmod|START_ENTITY potentiates|nsubj|modification modification|nmod|END_ENTITY	Small ubiquitin-like modifier -LRB- SUMO -RRB- modification of zinc_finger_protein_131 potentiates its negative effect on estrogen signaling .
17482558	0	estrogens	31,40	CYP27A1	20,27	estrogens	CYP27A1	MESH:D004967	1593	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of human CYP27A1 by estrogens and androgens in HepG2 and prostate cells .
16274925	0	estrogens	99,108	Cox-2	48,53	estrogens	Cox-2	MESH:D004967	29527(Tax:10116)	Chemical	Gene	modulation|nmod|START_ENTITY modulation|nmod|expression expression|appos|END_ENTITY	Tissue-specific modulation of cyclooxygenase-2 -LRB- Cox-2 -RRB- expression in the uterus and the v. cava by estrogens and phytoestrogens .
17826850	0	estrogens	70,79	Estrogen-receptor	0,17	estrogens	Estrogen-receptor	MESH:D004967	2099	Chemical	Gene	effects|nmod|START_ENTITY effects|amod|END_ENTITY	Estrogen-receptor independent effects of two ubiquitous environmental estrogens on Melosira varians Agardh , a common component of the aquatic primary production community .
15664448	0	estrogens	73,82	Estrogen_receptor	0,17	estrogens	Estrogen receptor	MESH:D004967	2099	Chemical	Gene	effects|nmod|START_ENTITY effects|amod|END_ENTITY	Estrogen_receptor independent rapid non-genomic effects of environmental estrogens on -LSB- Ca2 + -RSB- i in human breast_cancer cells .
2356999	0	estrogens	26,35	GCDFP-15	53,61	estrogens	GCDFP-15	MESH:D004967	5304	Chemical	Gene	antagonism|nmod|START_ENTITY antagonism|nmod|expression expression|compound|END_ENTITY	Potent antagonism between estrogens and androgens on GCDFP-15 expression and cell growth in the ZR-75-1 human breast_cancer cells .
2626033	0	estrogens	19,28	GCDFP-15	112,120	estrogens	GCDFP-15	MESH:D004967	5304	Chemical	Gene	Antagonism|nmod|START_ENTITY Antagonism|nmod|expression expression|nmod|cells cells|nmod|END_ENTITY	Antagonism between estrogens and androgens on GCDFP-15 gene expression in ZR-75-1 cells and correlation between GCDFP-15 and estrogen as well as progesterone_receptor expression in human breast_cancer .
2626033	0	estrogens	19,28	GCDFP-15	46,54	estrogens	GCDFP-15	MESH:D004967	5304	Chemical	Gene	Antagonism|nmod|START_ENTITY Antagonism|nmod|expression expression|compound|END_ENTITY	Antagonism between estrogens and androgens on GCDFP-15 gene expression in ZR-75-1 cells and correlation between GCDFP-15 and estrogen as well as progesterone_receptor expression in human breast_cancer .
2725533	0	estrogens	21,30	GCDFP-15	34,42	estrogens	GCDFP-15	MESH:D004967	5304	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Inhibitory effect of estrogens on GCDFP-15 mRNA levels and secretion in ZR-75-1 human breast_cancer cells .
20382141	0	estrogens	102,111	G_protein-coupled_estrogen_receptor_1	8,45	estrogens	G protein-coupled estrogen receptor 1	MESH:D004967	565271(Tax:7955)	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of G_protein-coupled_estrogen_receptor_1 , GPER , in inhibition of oocyte maturation by endogenous estrogens in zebrafish .
34354	0	estrogens	92,101	Growth_hormone	1,15	estrogens	Growth hormone	MESH:D004967	81668(Tax:10116)	Chemical	Gene	-RSB-|amod|START_ENTITY induced|nmod|-RSB- sites|acl|induced sites|compound|END_ENTITY	-LSB- Growth_hormone specific binding sites : characteristics of lactogenic receptors induced by estrogens -LRB- author 's transl -RRB- -RSB- .
9438921	0	estrogens	19,28	ICAM-1	70,76	estrogens	ICAM-1	MESH:D004967	3383	Chemical	Gene	START_ENTITY|advcl|circulating circulating|dobj|END_ENTITY	Lack of endogenous estrogens effects on circulating adhesion molecule ICAM-1 .
17045571	0	estrogens	146,155	IGF-I	54,59	estrogens	IGF-I	MESH:D004967	3479	Chemical	Gene	requirement|amod|START_ENTITY regulates|nmod|requirement regulates|dobj|insulin-like_growth_factor-I insulin-like_growth_factor-I|appos|END_ENTITY	Estradiol regulates the insulin-like_growth_factor-I -LRB- IGF-I -RRB- signalling pathway : a crucial role of phosphatidylinositol 3-kinase -LRB- PI 3-kinase -RRB- in estrogens requirement for growth of MCF-7 human breast_carcinoma cells .
18057377	0	estrogens	42,51	IGF-I	55,60	estrogens	IGF-I	MESH:D004967	3479	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|levels levels|amod|END_ENTITY	Administration route-dependent effects of estrogens on IGF-I levels during fixed GH replacement in women with hypopituitarism .
9744517	0	estrogens	10,19	IL-1beta	23,31	estrogens	IL-1beta	MESH:D004967	3553	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|compound|END_ENTITY	Effect of estrogens on IL-1beta promoter activity .
9867255	0	estrogens	24,33	IL-1beta	37,45	estrogens	IL-1beta	MESH:D004967	3553	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|compound|END_ENTITY	Effect of environmental estrogens on IL-1beta promoter activity in a macrophage cell line .
194801	0	estrogens	29,38	LH-RH	58,63	estrogens	LH-RH	MESH:D004967	2796	Chemical	Gene	START_ENTITY|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Effect of natural exogenous estrogens on the response to LH-RH -LRB- author 's transl -RRB- -RSB- .
9459197	0	estrogens	36,45	Progesterone_receptor	0,21	estrogens	Progesterone receptor	MESH:D004967	25154(Tax:10116)	Chemical	Gene	repression|nmod|START_ENTITY repression|amod|END_ENTITY	Progesterone_receptor repression by estrogens in rat uterine epithelial cells .
180740	3	estrogens	502,511	Prolactin	455,464	estrogens	prolactin	MESH:D004967	5617	Chemical	Gene	synthesis|nmod|START_ENTITY stimulated|dobj|synthesis stimulated|nsubj|END_ENTITY	Prolactin and ACTH stimulated the synthesis of estrogens by the tissue whereas GH , LH and ACTH were more effective than prolactin in stimulating androgen synthesis .
7556019	0	estrogens	37,46	Vitellogenin	0,12	estrogens	Vitellogenin	MESH:D004967	378512(Tax:8355)	Chemical	Gene	induction|nmod|START_ENTITY induction|nsubj|END_ENTITY	Vitellogenin induction by xenobiotic estrogens in the red-eared turtle and African_clawed_frog .
11714848	0	estrogens	65,74	apolipoprotein_A-I	20,38	estrogens	apolipoprotein A-I	MESH:D004967	335	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of human apolipoprotein_A-I gene expression by equine estrogens .
2504861	0	estrogens	26,35	apolipoprotein_A-I	56,74	estrogens	apolipoprotein A-I	MESH:D004967	25081(Tax:10116)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|A-II A-II|compound|END_ENTITY	Influence of development , estrogens , and food intake on apolipoprotein_A-I , A-II , and E mRNA in rat liver and intestine .
1973827	0	estrogens	46,55	c-erbB-2	14,22	estrogens	c-erbB-2	MESH:D004967	2064	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|expression expression|amod|END_ENTITY	Inhibition of c-erbB-2 oncogene expression by estrogens in human breast_cancer cells .
9272419	0	estrogens	19,28	c-erbB-2	32,40	estrogens	c-erbB-2	MESH:D004967	2064	Chemical	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	In vivo effects of estrogens on c-erbB-2 oncoprotein levels in chorionic villous tissue and maternal serum .
8843020	0	estrogens	23,32	corticotropin-releasing_factor	36,66	estrogens	corticotropin-releasing factor	MESH:D004967	81648(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	The modulatory role of estrogens on corticotropin-releasing_factor gene expression in the hypothalamic paraventricular nucleus of ovariectomized rats : role of the adrenal gland .
16274925	0	estrogens	99,108	cyclooxygenase-2	30,46	estrogens	cyclooxygenase-2	MESH:D004967	29527(Tax:10116)	Chemical	Gene	modulation|nmod|START_ENTITY modulation|nmod|expression expression|amod|END_ENTITY	Tissue-specific modulation of cyclooxygenase-2 -LRB- Cox-2 -RRB- expression in the uterus and the v. cava by estrogens and phytoestrogens .
6973463	0	estrogens	93,102	cytochrome_P-450	36,52	estrogens	cytochrome P-450	MESH:D004967	397687(Tax:9823)	Chemical	Gene	microsomal|nmod|START_ENTITY microsomal|xcomp|END_ENTITY	Inhibition of testicular microsomal cytochrome_P-450 -LRB- 17 alpha-hydroxylase/C -17,20 - lyase -RRB- by estrogens .
19347870	0	estrogens	63,72	epidermal_growth_factor_receptor	19,51	estrogens	epidermal growth factor receptor	MESH:D004967	1956	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Down-regulation of epidermal_growth_factor_receptor induced by estrogens and phytoestrogens promotes the differentiation of U2OS human osteosarcoma cells .
10099132	0	estrogens	102,111	estrogen-receptor	31,48	estrogens	estrogen-receptor	MESH:D004967	2099	Chemical	Gene	templates|nmod|START_ENTITY templates|nmod|ligands ligands|amod|END_ENTITY	Novel structural templates for estrogen-receptor ligands and prospects for combinatorial synthesis of estrogens .
12196720	0	estrogens	61,70	estrogen-receptor	92,109	estrogens	estrogen-receptor	MESH:D004967	2099	Chemical	Gene	vitro|nmod|START_ENTITY vitro|nmod|breast_cancer breast_cancer|amod|END_ENTITY	In vitro regulation of vascular_endothelial_growth_factor by estrogens and antiestrogens in estrogen-receptor positive breast_cancer .
10377031	0	estrogens	127,136	estrogen_receptor	27,44	estrogens	estrogen receptor	MESH:D004967	2099	Chemical	Gene	affinity|nmod|START_ENTITY characteristics|dep|affinity characteristics|nmod|END_ENTITY	Binding characteristics of estrogen_receptor -LRB- ER -RRB- in Atlantic croaker -LRB- Micropogonias undulatus -RRB- testis : different affinity for estrogens and xenobiotics from that of hepatic ER .
10656848	0	estrogens	14,23	estrogen_receptor	56,73	estrogens	estrogen receptor	MESH:D004967	2099	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|dimers dimers|compound|END_ENTITY	Environmental estrogens induce transcriptionally active estrogen_receptor dimers in yeast : activity potentiated by the coactivator RIP140 .
11037623	0	estrogens	23,32	estrogen_receptor	47,64	estrogens	estrogen receptor	MESH:D004967	2099	Chemical	Gene	modulators|amod|START_ENTITY modulators|compound|END_ENTITY	Mechanism of action of estrogens and selective estrogen_receptor modulators .
14604660	0	estrogens	32,41	estrogen_receptor	119,136	estrogens	estrogen receptor	MESH:D004967	2099	Chemical	Gene	containing|nsubj|START_ENTITY containing|parataxis|using using|nsubj|synthesis synthesis|nmod|agents agents|compound|END_ENTITY	7alpha - and 17alpha-substituted estrogens containing tridentate tricarbonyl_rhenium / technetium complexes : synthesis of estrogen_receptor imaging agents and evaluation using microPET with technetium-94m .
1868844	0	estrogens	29,38	estrogen_receptor	113,130	estrogens	estrogen receptor	MESH:D004967	2099	Chemical	Gene	interactions|nmod|START_ENTITY interactions|nmod|END_ENTITY	Differential interactions of estrogens and antiestrogens at the 17 beta-hydroxy or counterpart function with the estrogen_receptor .
18703623	0	estrogens	86,95	estrogen_receptor	27,44	estrogens	estrogen receptor	MESH:D004967	2099	Chemical	Gene	modulator|nmod|START_ENTITY modulator|nsubj|pairing pairing|nmod|END_ENTITY	The pairing of a selective estrogen_receptor modulator , bazedoxifene , with conjugated estrogens as a new paradigm for the treatment of menopausal_symptoms and osteoporosis prevention .
20926581	0	estrogens	41,50	estrogen_receptor	102,119	estrogens	estrogen receptor	MESH:D004967	2099	Chemical	Gene	actions|nmod|START_ENTITY signaling|dobj|actions Rapid|acl|signaling mediated|nsubjpass|Rapid mediated|nmod|END_ENTITY	Rapid signaling actions of environmental estrogens in developing granule cell neurons are mediated by estrogen_receptor .
21420388	0	estrogens	71,80	estrogen_receptor	31,48	estrogens	estrogen receptor	MESH:D004967	2099	Chemical	Gene	evolution|nmod|START_ENTITY END_ENTITY|nmod|evolution	Insights from the structure of estrogen_receptor into the evolution of estrogens : implications for endocrine disruption .
23033157	0	estrogens	14,23	estrogen_receptor	118,135	estrogens	estrogen receptor	MESH:D004967	2099	Chemical	Gene	START_ENTITY|dep|evaluation evaluation|nmod|ligands ligands|compound|END_ENTITY	Bicyclic core estrogens as full antagonists : synthesis , biological evaluation and structure-activity relationships of estrogen_receptor ligands based on bridged oxabicyclic_core_arylsulfonamides .
24434499	0	estrogens	100,109	estrogen_receptor	14,31	estrogens	estrogen receptor	MESH:D004967	2099	Chemical	Gene	detection|nmod|START_ENTITY homogeneous|nmod|detection homogeneous|nsubj|fragment-based fragment-based|compound|END_ENTITY	A recombinant estrogen_receptor fragment-based homogeneous fluorescent assay for rapid detection of estrogens .
24937418	0	estrogens	168,177	estrogen_receptor	72,89	estrogens	estrogen receptor	MESH:D004967	100136026(Tax:8022)	Chemical	Gene	role|nmod|START_ENTITY indication|nmod|role Expression|dep|indication Expression|nmod|localization localization|nmod|ERa1 ERa1|amod|END_ENTITY	Expression of gene , protein and immunohistochemical localization of the estrogen_receptor isoform ERa1 in male rainbow_trout lymphoid organs ; indication of the role of estrogens in the regulation of immune mechanisms .
3196678	0	estrogens	15,24	estrogen_receptor	67,84	estrogens	estrogen receptor	MESH:D004967	2099	Chemical	Gene	START_ENTITY|dep|synthesis synthesis|dep|interaction interaction|nmod|END_ENTITY	Organometallic estrogens : synthesis , interaction with lamb uterine estrogen_receptor , and detection by infrared spectroscopy .
7789614	0	estrogens	97,106	estrogen_receptor	14,31	estrogens	estrogen receptor	MESH:D004967	2099	Chemical	Gene	sensitivity|nmod|START_ENTITY specificity|nmod|sensitivity presents|dobj|specificity presents|nsubj|END_ENTITY	Rainbow_trout estrogen_receptor presents an equal specificity but a differential sensitivity for estrogens than human estrogen_receptor .
8625307	0	estrogens	42,51	estrogen_receptor	10,27	estrogens	estrogen receptor	MESH:D004967	2099	Chemical	Gene	Models|nmod|START_ENTITY Models|nmod|regulation regulation|compound|END_ENTITY	Models of estrogen_receptor regulation by estrogens and antiestrogens in breast_cancer cell lines .
8833652	0	estrogens	101,110	estrogen_receptor	6,23	estrogens	estrogen receptor	MESH:D004967	2099	Chemical	Gene	interpret|nmod|START_ENTITY receptors|acl:relcl|interpret mutants|dep|receptors mutants|compound|END_ENTITY	Human estrogen_receptor ligand activity inversion mutants : receptors that interpret antiestrogens as estrogens and estrogens as antiestrogens and discriminate among different antiestrogens .
9030571	0	estrogens	106,115	estrogen_receptor	32,49	estrogens	estrogen receptor	MESH:D004967	2099	Chemical	Gene	recognition|nmod|START_ENTITY involved|nmod|recognition involved|nsubjpass|residues residues|nmod|END_ENTITY	Different residues of the human estrogen_receptor are involved in the recognition of structurally diverse estrogens and antiestrogens .
9830682	0	estrogens	18,27	estrogen_receptor	119,136	estrogens	estrogen receptor	MESH:D004967	2099	Chemical	Gene	Exchange|nmod|START_ENTITY Exchange|dep|evidence evidence|nmod|configurations configurations|nmod|END_ENTITY	Exchange of bound estrogens and antiestrogens in MCF-7 cells : evidence for ligand-induced stable configurations of the estrogen_receptor .
10965916	0	estrogens	101,110	estrogen_receptor-alpha	127,150	estrogens	estrogen receptor-alpha	MESH:D004967	13982(Tax:10090)	Chemical	Gene	signaling|nmod|START_ENTITY insulin-like_growth_factor_I|acl|signaling Activation|nmod|insulin-like_growth_factor_I Activation|dep|requirement requirement|nmod|END_ENTITY	Activation of a uterine insulin-like_growth_factor_I signaling pathway by clinical and environmental estrogens : requirement of estrogen_receptor-alpha .
19910454	0	estrogens	38,47	estrogen_receptor-alpha	76,99	estrogens	estrogen receptor-alpha	MESH:D004967	2099	Chemical	Gene	action|nmod|START_ENTITY mediated|nsubjpass|action mediated|nmod|END_ENTITY	Minireview : osteoprotective action of estrogens is mediated by osteoclastic estrogen_receptor-alpha .
20053716	0	estrogens	78,87	estrogen_receptor-alpha	4,27	estrogens	estrogen receptor-alpha	MESH:D004967	13982(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY mediates|dobj|effects mediates|nsubj|END_ENTITY	The estrogen_receptor-alpha in osteoclasts mediates the protective effects of estrogens on cancellous but not cortical bone .
9927308	0	estrogens	41,50	estrogen_receptor-alpha	72,95	estrogens	estrogen receptor-alpha	MESH:D004967	2099	Chemical	Gene	START_ENTITY|nmod|receptor-beta receptor-beta|compound|END_ENTITY	Novel ligands that function as selective estrogens or antiestrogens for estrogen_receptor-alpha or estrogen receptor-beta .
12069588	0	estrogens	29,38	estrogen_receptor_alpha	137,160	estrogens	estrogen receptor alpha	MESH:D004967	2099	Chemical	Gene	interactions|nmod|START_ENTITY interactions|nmod|END_ENTITY	Differential interactions of estrogens and antiestrogens at the 17 beta-hydroxyl or counterpart hydroxyl with histidine 524 of the human estrogen_receptor_alpha .
180042	0	estrogens	87,96	growth_hormone	107,121	estrogens	growth hormone	MESH:D004967	2688	Chemical	Gene	administration|amod|START_ENTITY administration|compound|END_ENTITY	Testosterone-estradiol-binding globulin in patients with Turner 's _ syndrome : effects of estrogens and acute growth_hormone administration .
24281711	0	estrogens	17,26	growth_hormone	72,86	estrogens	growth hormone	MESH:D004967	2688	Chemical	Gene	influence|nmod|START_ENTITY influence|nmod|END_ENTITY	The influence of estrogens on the biological and therapeutic actions of growth_hormone in the liver .
10805720	0	estrogens	57,66	hTERT	13,18	estrogens	hTERT	MESH:D004967	7015	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|expression expression|amod|END_ENTITY	Induction of hTERT expression and telomerase activity by estrogens in human ovary epithelium cells .
8147234	0	estrogens	40,49	insulin-like_growth_factor_1	79,107	estrogens	insulin-like growth factor 1	MESH:D004967	3479	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|levels levels|amod|END_ENTITY	Differential effects of oral conjugated estrogens and transdermal estradiol on insulin-like_growth_factor_1 , growth_hormone and sex_hormone_binding_globulin serum levels .
10965916	0	estrogens	101,110	insulin-like_growth_factor_I	24,52	estrogens	insulin-like growth factor I	MESH:D004967	16000(Tax:10090)	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Activation of a uterine insulin-like_growth_factor_I signaling pathway by clinical and environmental estrogens : requirement of estrogen_receptor-alpha .
15331887	0	estrogens	59,68	low-density_lipoprotein_receptor	14,46	estrogens	low-density lipoprotein receptor	MESH:D004967	3949	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|activity activity|amod|END_ENTITY	Regulation of low-density_lipoprotein_receptor activity by estrogens and phytoestrogens in a HepG2 cell model .
10614622	0	estrogens	94,103	monocyte_chemoattractant_protein-1	40,74	estrogens	monocyte chemoattractant protein-1	MESH:D004967	6347	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Molecular analysis of the inhibition of monocyte_chemoattractant_protein-1 gene expression by estrogens and xenoestrogens in MCF-7 cells .
2460749	0	estrogens	78,87	pS2	14,17	estrogens	pS2	MESH:D004967	338412	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of pS2 gene expression by affinity labeling and reversibly binding estrogens and antiestrogens : comparison of effects on the native gene and on pS2-chloramphenicol_acetyltransferase fusion genes transfected into MCF-7 human breast_cancer cells .
8334130	0	estrogens	76,85	pS2	26,29	estrogens	pS2	MESH:D004967	338412	Chemical	Gene	induction|nmod|START_ENTITY induction|nmod|mRNAs mRNAs|amod|END_ENTITY	Differential induction of pS2 and cathepsin_D mRNAs by structurally altered estrogens .
2850907	0	estrogens	10,19	parathyroid_hormone	47,66	estrogens	parathyroid hormone	MESH:D004967	5741	Chemical	Gene	Effect|nmod|START_ENTITY Effect|acl|END_ENTITY	Effect of estrogens on renal responsiveness to parathyroid_hormone in elderly female subjects .
12354672	0	estrogens	10,19	progesterone_receptor	49,70	estrogens	progesterone receptor	MESH:D004967	25154(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of estrogens on ontogenetic expression of progesterone_receptor in the fetal female rat reproductive tract .
21918635	0	estrogens	12,21	progesterone_receptor	32,53	estrogens	progesterone receptor	MESH:D004967	5241	Chemical	Gene	START_ENTITY|nmod|A A|compound|END_ENTITY	Affinity of estrogens for human progesterone_receptor A and B monomers and risk of breast_cancer : a comparative molecular modeling study .
3199824	0	estrogens	105,114	progesterone_receptor	47,68	estrogens	progesterone receptor	MESH:D004967	5241	Chemical	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	Analogies and differences in the modulation of progesterone_receptor induction and cell proliferation by estrogens and antiestrogens in MCF-7 human breast_cancer cells : study with 24 triphenylacrylonitrile derivatives .
1963474	0	estrogens	150,159	prolactin	89,98	estrogens	prolactin	MESH:D004967	24683(Tax:10116)	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|interaction interaction|nmod|gene gene|compound|END_ENTITY	An interaction between the 5 ' flanking distal and proximal regulatory domains of the rat prolactin gene is required for transcriptional activation by estrogens .
2124656	0	estrogens	11,20	prolactin	74,83	estrogens	prolactin	MESH:D004967	24683(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY evaluated|nsubj|Effects evaluated|advmod|as as|nmod:npmod|cells cells|nummod|END_ENTITY	Effects of estrogens on the ultrastructural characteristics of female rat prolactin cells as evaluated by in situ hybridization in combination with immunogold staining technique .
2260915	0	estrogens	10,19	prolactin	23,32	estrogens	prolactin	MESH:D004967	5617	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Effect of estrogens on prolactin secretion in transsexual subjects .
6802681	0	estrogens	126,135	prolactin	12,21	estrogens	prolactin	MESH:D004967	5617	Chemical	Gene	role|nmod|START_ENTITY response|dep|role response|compound|END_ENTITY	Exaggerated prolactin response of thyrotropin-releasing_hormone in women with anovulatory_cycles : possible role of endogenous estrogens and effect of bromocriptine .
2668279	0	estrogens	55,64	protein_disulfide_isomerase	24,51	estrogens	protein disulfide isomerase	MESH:D004967	20468271	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Selective inhibition of protein_disulfide_isomerase by estrogens .
16899995	0	estrogens	44,53	sulfatase	23,32	estrogens	sulfatase	MESH:D004967	347527	Chemical	Gene	metabolism|amod|START_ENTITY pathway|nmod|metabolism pathway|amod|END_ENTITY	Effects of tibolone on sulfatase pathway of estrogens metabolism and on growth of MCF-7 human breast_tumors implanted in ovariectomized nude_mice .
15857755	0	estrogens	24,33	tissue_factor_pathway_inhibitor	70,101	estrogens	tissue factor pathway inhibitor	MESH:D004967	29436(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Differential effects of estrogens and progestins on the anticoagulant tissue_factor_pathway_inhibitor in the rat .
6092783	0	estrogens	57,66	tyrosinase	79,89	estrogens	tyrosinase	MESH:D004967	7299	Chemical	Gene	labeled|dobj|START_ENTITY labeled|nmod|END_ENTITY	Regiospecific transfer of tritium into 3H2O from labeled estrogens by mushroom tyrosinase .
11035983	0	estrogens	63,72	vascular_endothelial_growth_factor	14,48	estrogens	vascular endothelial growth factor	MESH:D004967	7422	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of vascular_endothelial_growth_factor expression by estrogens and progestins .
12196720	0	estrogens	61,70	vascular_endothelial_growth_factor	23,57	estrogens	vascular endothelial growth factor	MESH:D004967	7422	Chemical	Gene	vitro|nmod|START_ENTITY vitro|dobj|regulation regulation|nmod|END_ENTITY	In vitro regulation of vascular_endothelial_growth_factor by estrogens and antiestrogens in estrogen-receptor positive breast_cancer .
17665642	0	estrogens	41,50	vascular_endothelial_growth_factor	67,101	estrogens	vascular endothelial growth factor	MESH:D004967	7422	Chemical	Gene	effect|nmod|START_ENTITY Mechanisms|nmod|effect associated|nsubj|Mechanisms associated|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Mechanisms of neuroprotective effect of estrogens associated with vascular_endothelial_growth_factor expression -RSB- .
10352949	0	estrone	53,60	Leptin	0,6	estrone	Leptin	MESH:D004970	25608(Tax:10116)	Chemical	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	Leptin enhances the synthesis of oleoyl-estrone from estrone in white_adipose_tissue .
6200695	0	estrone	75,82	alpha_1_fetoprotein	24,43	estrone	alpha 1 fetoprotein	MESH:D004970	24177(Tax:10116)	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction between rat alpha_1_fetoprotein and fluorescent derivatives of estrone in relation to the position and type of the fluorescent label .
24279177	0	estrone	93,100	interleukin_1beta	125,142	estrone	interleukin 1beta	MESH:D004970	396565(Tax:9823)	Chemical	Gene	START_ENTITY|nmod|presence presence|nmod|END_ENTITY	Novel aspects of cytokine action in porcine uterus -- endometrial and myometrial production of estrone -LRB- E1 -RRB- in the presence of interleukin_1beta -LRB- IL1beta -RRB- , interleukin_6 -LRB- IL6 -RRB- and tumor_necrosis_factor -LRB- TNFalpha -RRB- -- in vitro study .
10397281	0	estrone	38,45	prolactin	61,70	estrone	prolactin	MESH:D004970	5617	Chemical	Gene	cortisol|dep|START_ENTITY cortisol|dep|END_ENTITY	Acute effect of alcohol on estradiol , estrone , progesterone , prolactin , cortisol , and luteinizing hormone in premenopausal women .
11078439	0	estrone	92,99	renin	164,169	estrone	renin	MESH:D004970	5972	Chemical	Gene	active|amod|START_ENTITY END_ENTITY|amod|active	Plasma endothelin and LH-RH , LH , FSH , prolactin , progesterone , 17alpha-hydroxyprogesterone , estrone , 17beta-estradiol , delta4-androstenedione , testosterone , active renin , angiotensin-II and ANP levels in blood and LH , estrone and 17beta-estradiol and pregnanediol levels in urine of normal cycling women .
9361395	0	estrone	32,39	sulfatase	40,49	estrone	sulfatase	MESH:D004970	347527	Chemical	Gene	activities|amod|START_ENTITY activities|amod|END_ENTITY	Role , control and expression of estrone sulfatase and 17_beta-hydroxysteroid_dehydrogenase activities in human breast_cancer .
8417823	0	estrone-3-methylthiophosphonate	44,75	estrone_sulfatase	14,31	estrone-3-methylthiophosphonate	estrone sulfatase	MESH:C079020	412	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Inhibition of estrone_sulfatase activity by estrone-3-methylthiophosphonate : a potential therapeutic agent in breast_cancer .
20610891	9	estrone_3-sulfate	1198,1215	digoxin	1169,1176	estrone 3-sulfate	OATP4C1	MESH:C017296	353189	Chemical	Gene	transport|amod|START_ENTITY END_ENTITY|nmod|transport	The estimated IC -LRB- 50 -RRB- value of digoxin for OATP4C1-mediated estrone_3-sulfate transport was 119 microM .
1912612	0	estrone_sulfate	76,91	Estrone_sulfatase	0,17	estrone sulfate	Estrone sulfatase	MESH:C017296	412	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Estrone_sulfatase activity and effect of antiestrogens on transformation of estrone_sulfate in hormone-dependent vs. independent human breast_cancer cell lines .
1177375	0	ethacrynic_acid	13,28	renin	43,48	ethacrynic acid	renin	MESH:D004976	403838(Tax:9615)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|mechanisms mechanisms|compound|END_ENTITY	Influence of ethacrynic_acid on intrarenal renin release mechanisms .
176034	0	ethacrynic_acid	95,110	renin	30,35	ethacrynic acid	renin	MESH:D004976	5972	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Effect Effect|nmod|aldosterone aldosterone|appos|activity activity|compound|END_ENTITY	Effect on plasma aldosterone , renin activity and cortisol of acute volume depletion induced by ethacrynic_acid under constant infusion of angiotensin_II and dexamethasone in man .
2171356	0	ethacrynic_acid	34,49	renin	15,20	ethacrynic acid	renin	MESH:D004976	100358545(Tax:9986)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Stimulation of renin secretion by ethacrynic_acid is independent of Na -LRB- + -RRB- - K -LRB- + -RRB- -2 Cl - cotransport .
12565720	0	ethamsylate	21,32	P-selectin	42,52	ethamsylate	P-selectin	MESH:D004979	6403	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	The hemostatic agent ethamsylate enhances P-selectin membrane expression in human platelets and cultured endothelial cells .
2550299	0	ethane_dimethane_sulphonate	10,37	proopiomelanocortin	41,60	ethane dimethane sulphonate	proopiomelanocortin	null	24664(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|mRNA mRNA|amod|END_ENTITY	Effect of ethane_dimethane_sulphonate on proopiomelanocortin -LRB- POMC -RRB- mRNA and POMC-derived peptides in the rat testis .
14667001	0	ethane_dimethanesulfonate	35,60	CD-1	64,68	ethane dimethanesulfonate	CD-1	MESH:C002994	111334(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|compound|END_ENTITY	Effects of gestational exposure to ethane_dimethanesulfonate in CD-1 mice : microtia and preliminary hearing tests .
12072158	0	ethanol	57,64	5-HT1A_receptor	0,15	ethanol	5-HT1A receptor	MESH:D000431	15550(Tax:10090)	Chemical	Gene	blockade|nmod|START_ENTITY blockade|amod|END_ENTITY	5-HT1A_receptor blockade and the motivational profile of ethanol .
17575556	0	ethanol	25,32	A10	107,110	ethanol	A10	MESH:D000431	28870	Chemical	Gene	tolerance|compound|START_ENTITY tolerance|nmod|END_ENTITY	Effect of temperature on ethanol tolerance of a thermophilic anaerobic ethanol producer Thermoanaerobacter A10 : modeling and simulation .
16358971	0	ethanol	109,116	ALDH	67,71	ethanol	ALDH	MESH:D000431	25375(Tax:10116)	Chemical	Gene	consumption|compound|START_ENTITY rats|nmod|consumption liver|nmod|rats effect|nmod|liver effect|appos|END_ENTITY	The effect of green tea on the activity of aldehyde_dehydrogenase -LRB- ALDH -RRB- in the liver of rats during chronic ethanol consumption .
17530188	0	ethanol	118,125	ALDH	99,103	ethanol	ALDH	MESH:D000431	25375(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Decreased dopamine D -LRB- 2 -RRB- receptor function in cerebral cortex and brain stem : their role in hepatic ALDH regulation in ethanol treated rats .
18536982	0	ethanol	147,154	ALDH	128,132	ethanol	ALDH	MESH:D000431	25375(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	Enhanced dopamine D2 receptor function in hypothalamus and corpus striatum : their role in liver , plasma and in vitro hepatocyte ALDH regulation in ethanol treated rats .
7887984	1	ethanol	253,260	ALDH	201,205	ethanol	ALDH	MESH:D000431	25375(Tax:10116)	Chemical	Gene	ingestion|compound|START_ENTITY causing|nmod|ingestion inhibits|dep|causing inhibits|nsubj|aldehyde_dehydrogenase aldehyde_dehydrogenase|appos|END_ENTITY	Disulfiram inhibits hepatic aldehyde_dehydrogenase -LRB- ALDH -RRB- causing an accumulation of acetaldehyde after ethanol ingestion .
10826103	0	ethanol	70,77	ALDH2	19,24	ethanol	ALDH2	MESH:D000431	217	Chemical	Gene	elimination|compound|START_ENTITY genotypes|nmod|elimination effects|parataxis|genotypes effects|nmod|END_ENTITY	The effects of the ALDH2 * 1/2 , CYP2E1 C1/C2 _ and_C / D genotypes on blood ethanol elimination .
16316071	0	ethanol	12,19	ALDH2	89,94	ethanol	ALDH2	MESH:D000431	217	Chemical	Gene	ingestion|compound|START_ENTITY Effects|nmod|ingestion Effects|nmod|people people|nmod|genotypes genotypes|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Effects of ethanol ingestion on glucose tolerance in people with different genotypes of ALDH2 -RSB- .
17965556	0	ethanol	26,33	ALDH2	47,52	ethanol	ALDH2	MESH:D000431	11669(Tax:10090)	Chemical	Gene	treatment|compound|START_ENTITY treatment|nmod|mice mice|compound|END_ENTITY	A pilot study on subacute ethanol treatment of ALDH2 KO mice .
18925476	0	ethanol	109,116	ALDH2	13,18	ethanol	ALDH2	MESH:D000431	29539(Tax:10116)	Chemical	Gene	vapors|compound|START_ENTITY exposed|nmod|vapors exposed|nsubj|Influence Influence|nmod|polymorphism polymorphism|compound|END_ENTITY	Influence of ALDH2 polymorphism on ethanol kinetics and pulmonary effects in male and female rats exposed to ethanol vapors .
18925476	0	ethanol	35,42	ALDH2	13,18	ethanol	ALDH2	MESH:D000431	29539(Tax:10116)	Chemical	Gene	kinetics|compound|START_ENTITY polymorphism|nmod|kinetics polymorphism|compound|END_ENTITY	Influence of ALDH2 polymorphism on ethanol kinetics and pulmonary effects in male and female rats exposed to ethanol vapors .
21785800	0	ethanol	53,60	ALDH2	87,92	ethanol	ALDH2	MESH:D000431	217	Chemical	Gene	START_ENTITY|nmod|analysis analysis|nmod|END_ENTITY	Non-invasive spatial visualization system of exhaled ethanol for real-time analysis of ALDH2 related alcohol metabolism .
22455355	0	ethanol	21,28	ALDH2	133,138	ethanol	ALDH2	MESH:D000431	217	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|men men|nmod|genotypes genotypes|compound|END_ENTITY	The acute effects of ethanol and acetaldehyde on physiological responses after ethanol ingestion in young healthy men with different ALDH2 genotypes .
22455355	0	ethanol	79,86	ALDH2	133,138	ethanol	ALDH2	MESH:D000431	217	Chemical	Gene	ingestion|compound|START_ENTITY responses|nmod|ingestion effects|nmod|responses effects|nmod|men men|nmod|genotypes genotypes|compound|END_ENTITY	The acute effects of ethanol and acetaldehyde on physiological responses after ethanol ingestion in young healthy men with different ALDH2 genotypes .
24058561	0	ethanol	78,85	ALDH2	0,5	ethanol	ALDH2	MESH:D000431	217	Chemical	Gene	presence|nmod|START_ENTITY has|nmod|presence has|nsubj|genotype genotype|compound|END_ENTITY	ALDH2 genotype has no effect on salivary acetaldehyde without the presence of ethanol in the systemic circulation .
24177029	0	ethanol	6,13	ALDH2	102,107	ethanol	ALDH2	MESH:D000431	11669(Tax:10090)	Chemical	Gene	preexposure|compound|START_ENTITY promotes|nsubj|preexposure promotes|advcl|activating activating|dobj|END_ENTITY	Acute ethanol preexposure promotes liver_regeneration after partial hepatectomy in mice by activating ALDH2 .
24571199	0	ethanol	24,31	ALDH2	93,98	ethanol	ALDH2	MESH:D000431	24188(Tax:10116)	Chemical	Gene	intake|compound|START_ENTITY intake|nmod|administration administration|nmod|aldehyde_dehydrogenase-2 aldehyde_dehydrogenase-2|appos|END_ENTITY	Long-term inhibition of ethanol intake by the administration of an aldehyde_dehydrogenase-2 -LRB- ALDH2 -RRB- - coding lentiviral vector into the ventral tegmental area of rats .
25244799	0	ethanol	35,42	ALDH2	26,31	ethanol	ALDH2	MESH:D000431	24188(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of activation of ALDH2 by ethanol on the expression of JNK in kidney of diabetic rats -RSB- .
26172086	0	ethanol	6,13	ALDH2	80,85	ethanol	ALDH2	MESH:D000431	29539(Tax:10116)	Chemical	Gene	consumption|compound|START_ENTITY aggravates|nsubj|consumption aggravates|advcl|inhibiting inhibiting|dobj|END_ENTITY	Heavy ethanol consumption aggravates the ischemic_cerebral_injury by inhibiting ALDH2 .
7598661	0	ethanol	5,12	ALDH2	71,76	ethanol	ALDH2	MESH:D000431	217	Chemical	Gene	elimination|compound|START_ENTITY pharmacokinetics|nsubj|elimination pharmacokinetics|dobj|effects effects|nmod|genotypes genotypes|nmod|END_ENTITY	-LSB- The ethanol elimination pharmacokinetics -- the effects of genotypes of ALDH2 and CYP2E1 on the ethanol metabolism -RSB- .
7598661	0	ethanol	95,102	ALDH2	71,76	ethanol	ALDH2	MESH:D000431	217	Chemical	Gene	-RSB-|compound|START_ENTITY effects|nmod|-RSB- effects|nmod|genotypes genotypes|nmod|END_ENTITY	-LSB- The ethanol elimination pharmacokinetics -- the effects of genotypes of ALDH2 and CYP2E1 on the ethanol metabolism -RSB- .
9011144	0	ethanol	5,12	ALDH2	71,76	ethanol	ALDH2	MESH:D000431	217	Chemical	Gene	elimination|compound|START_ENTITY pharmacokinetics|nsubj|elimination pharmacokinetics|dobj|effects effects|nmod|genotypes genotypes|nmod|END_ENTITY	-LSB- The ethanol elimination pharmacokinetics -- the effects of genotypes of ALDH2 and CYP2E1 on the ethanol metabolism -RSB- .
9011144	0	ethanol	95,102	ALDH2	71,76	ethanol	ALDH2	MESH:D000431	217	Chemical	Gene	-RSB-|compound|START_ENTITY effects|nmod|-RSB- effects|nmod|genotypes genotypes|nmod|END_ENTITY	-LSB- The ethanol elimination pharmacokinetics -- the effects of genotypes of ALDH2 and CYP2E1 on the ethanol metabolism -RSB- .
15578517	0	ethanol	58,65	AMP-activated_protein_kinase	12,40	ethanol	AMP-activated protein kinase	MESH:D000431	78975(Tax:10116)	Chemical	Gene	action|nmod|START_ENTITY role|nmod|action role|nmod|END_ENTITY	The role of AMP-activated_protein_kinase in the action of ethanol in the liver .
25730876	0	ethanol	36,43	ATF3	0,4	ethanol	ATF3	MESH:D000431	11910(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY mediates|dobj|effects mediates|nsubj|END_ENTITY	ATF3 mediates inhibitory effects of ethanol on hepatic gluconeogenesis .
21146245	0	ethanol	55,62	ATF4	0,4	ethanol	ATF4	MESH:D000431	468	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	ATF4 and the integrated stress response are induced by ethanol and cytochrome_P450_2E1 in human hepatocytes .
1385948	0	ethanol	11,18	ATPase	64,70	ethanol	ATPase	MESH:D000431	1769	Chemical	Gene	Effects|nmod|START_ENTITY analogues|nsubj|Effects analogues|nmod|END_ENTITY	Effects of ethanol and its fluorinated analogues on the calcium ATPase of sarcoplasmic reticulum .
10442016	0	ethanol	52,59	Alcohol_dehydrogenase	1,22	ethanol	Alcohol dehydrogenase	MESH:D000431	10327	Chemical	Gene	structure|acl|START_ENTITY END_ENTITY|dep|structure	-LSB- Alcohol_dehydrogenase -LRB- ADH -RRB- : structure and role in ethanol metabolism by the human gastrointestinal tract -RSB- .
1939174	0	ethanol	45,52	Alcohol_dehydrogenase	0,21	ethanol	Alcohol dehydrogenase	MESH:D000431	3771877(Tax:7227)	Chemical	Gene	flux|nmod|START_ENTITY controls|dobj|flux controls|nsubj|END_ENTITY	Alcohol_dehydrogenase controls the flux from ethanol into lipids in Drosophila larvae .
2124198	0	ethanol	41,48	Alcohol_dehydrogenase	1,22	ethanol	Alcohol dehydrogenase	MESH:D000431	3771877(Tax:7227)	Chemical	Gene	-LSB-|nmod|START_ENTITY -LSB-|dobj|END_ENTITY	-LSB- Alcohol_dehydrogenase and adaptation to ethanol in Drosophila -RSB- .
23824954	0	ethanol	86,93	Alcohol_dehydrogenase	0,21	ethanol	Alcohol dehydrogenase	MESH:D000431	10327	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Alcohol_dehydrogenase and cytochrome_P450_2E1 can be induced by long-term exposure to ethanol in cultured liver HEP-G2 cells .
17166675	0	ethanol	36,43	Aldh2	76,81	ethanol	Aldh2	MESH:D000431	11669(Tax:10090)	Chemical	Gene	covalent|nmod|START_ENTITY comparison|nmod|covalent metabolites|nsubj|comparison metabolites|nmod|genotype genotype|amod|END_ENTITY	A comparison of covalent binding of ethanol metabolites to DNA according to Aldh2 genotype .
19241529	0	ethanol	80,87	BAA-1163	65,73	ethanol	BAA-1163	MESH:D000431	7850774(Tax:592021)	Chemical	Gene	using|dobj|START_ENTITY END_ENTITY|acl|using	An improved protocol for electroporation of Oenococcus_oeni ATCC BAA-1163 using ethanol as immediate membrane fluidizing agent .
15583957	0	ethanol	119,126	BDNF	106,110	ethanol	BDNF	MESH:D000431	627	Chemical	Gene	damage|compound|START_ENTITY END_ENTITY|nmod|damage	Attenuation of brain_derived_neurotrophic_factor -LRB- BDNF -RRB- by ethanol and cytoprotective effect of exogenous BDNF against ethanol damage in neuronal cells .
10951621	0	ethanol	76,83	Bcl-2	15,20	ethanol	Bcl-2	MESH:D000431	596	Chemical	Gene	-RSB-|compound|START_ENTITY induced|nmod|-RSB- apoptosis|acl|induced vector|dep|apoptosis adenovirus|dobj|vector adenovirus|nsubj|Resistance Resistance|nmod|END_ENTITY	-LSB- Resistance of Bcl-2 adenovirus vector to HepG -LRB- 2 -RRB- cell apoptosis induced by ethanol -RSB- .
11791174	0	ethanol	30,37	Bcl-2	177,182	ethanol	Bcl-2	MESH:D000431	12043(Tax:10090)	Chemical	Gene	consumption|compound|START_ENTITY interleukin-6|nmod|consumption acts|amod|interleukin-6 acts|dep|involvement involvement|nmod|induction induction|nmod|proteins proteins|amod|END_ENTITY	Elevated interleukin-6 during ethanol consumption acts as a potential endogenous protective cytokine against ethanol-induced apoptosis in the liver : involvement of induction of Bcl-2 and Bcl-x -LRB- L -RRB- proteins .
20727705	0	ethanol	101,108	Bcl-2	12,17	ethanol	Bcl-2	MESH:D000431	100774873	Chemical	Gene	toxicity|compound|START_ENTITY cultured|nmod|toxicity cultured|nsubj|END_ENTITY	ER-targeted Bcl-2 and inhibition of ER-associated caspase-12 rescue cultured immortalized cells from ethanol toxicity .
9889302	0	ethanol	59,66	Bcl-2	0,5	ethanol	Bcl-2	MESH:D000431	12043(Tax:10090)	Chemical	Gene	neurotoxicity|compound|START_ENTITY protects|nmod|neurotoxicity protects|nsubj|overexpression overexpression|amod|END_ENTITY	Bcl-2 overexpression protects the neonatal cerebellum from ethanol neurotoxicity .
22546227	0	ethanol	75,82	Brain-derived_neurotrophic_factor	0,33	ethanol	Brain-derived neurotrophic factor	MESH:D000431	24225(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Brain-derived_neurotrophic_factor expression after acute administration of ethanol .
2077112	0	ethanol	38,45	CA1	53,56	ethanol	CA1	MESH:D000431	12346(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|cell cell|compound|END_ENTITY	Effect of perinatal administration of ethanol on the CA1 pyramidal cell of the hippocampus and Purkinje cell of the cerebellum : an ultrastructural survey .
7644136	0	ethanol	16,23	CA1	43,46	ethanol	CA1	MESH:D000431	310218(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|neurons neurons|compound|END_ENTITY	Acute action of ethanol on rat hippocampal CA1 neurons : effects on intracellular signaling .
8138953	0	ethanol	51,58	CA1	74,77	ethanol	CA1	MESH:D000431	310218(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|neurons neurons|compound|END_ENTITY	Potentiation of GABAA-mediated synaptic current by ethanol in hippocampal CA1 neurons : possible role of protein kinase C. Ethanol has been reported to interact with numerous voltage - and ligand-gated ion channels in central mammalian neurons .
11584151	0	ethanol	81,88	CB1	11,14	ethanol	CB1	MESH:D000431	25248(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY cannabinoid|nmod|administration cannabinoid|nsubj|Effects Effects|nmod|END_ENTITY	Effects of CB1 cannabinoid receptor blockade on ethanol preference after chronic ethanol administration .
15632692	0	ethanol	22,29	CCK-A_receptor	81,95	ethanol	CCK-A receptor	MESH:D000431	24889(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY requires|nsubj|effect requires|dobj|END_ENTITY	Stimulatory effect of ethanol on pancreatic secretion in conscious rats requires CCK-A_receptor .
19252308	0	ethanol	10,17	CYP2C9	79,85	ethanol	CYP2C9	MESH:D000431	1559	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of ethanol on S-warfarin and diclofenac metabolism by recombinant human CYP2C9 .1 .
10075087	0	ethanol	72,79	CYP2E1	168,174	ethanol	CYP2E1	MESH:D000431	1571	Chemical	Gene	all-trans-retinoic_acid|nmod|START_ENTITY reactions|amod|all-trans-retinoic_acid biosynthesis|nmod|reactions Inhibition|nmod|biosynthesis Inhibition|dep|role role|nmod|END_ENTITY	Inhibition of human prenatal biosynthesis of all-trans-retinoic_acid by ethanol , ethanol metabolites , and products of lipid peroxidation reactions : a possible role for CYP2E1 .
10667633	0	ethanol	30,37	CYP2E1	10,16	ethanol	CYP2E1	MESH:D000431	13106(Tax:10090)	Chemical	Gene	induction|nmod|START_ENTITY induction|nsubj|Effect Effect|nmod|END_ENTITY	Effect of CYP2E1 induction by ethanol on the immunotoxicity and genotoxicity of extended low-level benzene exposure .
10826103	0	ethanol	70,77	CYP2E1	30,36	ethanol	CYP2E1	MESH:D000431	1571	Chemical	Gene	elimination|compound|START_ENTITY genotypes|nmod|elimination effects|parataxis|genotypes effects|appos|C1/C2 C1/C2|compound|END_ENTITY	The effects of the ALDH2 * 1/2 , CYP2E1 C1/C2 _ and_C / D genotypes on blood ethanol elimination .
11003211	0	ethanol	59,66	CYP2E1	147,153	ethanol	CYP2E1	MESH:D000431	1571	Chemical	Gene	acetaldehyde|nmod|START_ENTITY accumulation|nmod|acetaldehyde catalysis|nmod|accumulation catalysis|dep|evaluation evaluation|nmod|contributions contributions|nmod|END_ENTITY	Enzymic catalysis of the accumulation of acetaldehyde from ethanol in human prenatal cephalic tissues : evaluation of the relative contributions of CYP2E1 , alcohol_dehydrogenase , and catalase/peroxidases .
11133247	0	ethanol	105,112	CYP2E1	14,20	ethanol	CYP2E1	MESH:D000431	1571	Chemical	Gene	hepatotoxicity|nmod|START_ENTITY minimizing|dobj|hepatotoxicity strategy|acl|minimizing strategy|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of CYP2E1 with natural agents may be a feasible strategy for minimizing the hepatotoxicity of ethanol .
12745874	0	ethanol	65,72	CYP2E1	39,45	ethanol	CYP2E1	MESH:D000431	25086(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Glucose inhibition of the induction of CYP2E1 mRNA expression by ethanol in FGC-4 cells .
1608922	0	ethanol	176,183	CYP2E1	131,137	ethanol	CYP2E1	MESH:D000431	25086(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|appos|END_ENTITY	Effects of dietary fat composition on activities of the microsomal ethanol oxidizing system and ethanol-inducible cytochrome P450 -LRB- CYP2E1 -RRB- in the liver of rats chronically fed ethanol .
1608922	0	ethanol	67,74	CYP2E1	131,137	ethanol	CYP2E1	MESH:D000431	25086(Tax:10116)	Chemical	Gene	system|compound|START_ENTITY activities|nmod|system composition|nmod|activities Effects|nmod|composition Effects|appos|END_ENTITY	Effects of dietary fat composition on activities of the microsomal ethanol oxidizing system and ethanol-inducible cytochrome P450 -LRB- CYP2E1 -RRB- in the liver of rats chronically fed ethanol .
16235733	0	ethanol	14,21	CYP2E1	109,115	ethanol	CYP2E1	MESH:D000431	1571	Chemical	Gene	effect|nmod|START_ENTITY effect|acl|overexpressing overexpressing|dobj|END_ENTITY	The effect of ethanol and nitric_oxide on the N-nitrosodimethylamine formation in HepG2 cells overexpressing CYP2E1 .
16344722	0	ethanol	30,37	CYP2E1	0,6	ethanol	CYP2E1	MESH:D000431	13106(Tax:10090)	Chemical	Gene	sensitivity|compound|START_ENTITY influence|dobj|sensitivity influence|nsubj|END_ENTITY	CYP2E1 and catalase influence ethanol sensitivity in the central nervous system .
17034788	0	ethanol	18,25	CYP2E1	0,6	ethanol	CYP2E1	MESH:D000431	1571	Chemical	Gene	induced|nmod|START_ENTITY induced|advmod|END_ENTITY	CYP2E1 induced by ethanol causes oxidative stress , proteasome inhibition and cytokeratin aggresome -LRB- Mallory body-like -RRB- formation .
17284772	0	ethanol	69,76	CYP2E1	93,99	ethanol	CYP2E1	MESH:D000431	1571	Chemical	Gene	strand|nmod|START_ENTITY DNA|acl|strand Induction|nmod|DNA dependent|nsubj|Induction dependent|nmod|expression expression|compound|END_ENTITY	Induction of DNA strand breaks and oxidative stress in HeLa cells by ethanol is dependent on CYP2E1 expression .
1747925	0	ethanol	56,63	CYP2E1	27,33	ethanol	CYP2E1	MESH:D000431	13106(Tax:10090)	Chemical	Gene	administration|compound|START_ENTITY END_ENTITY|nmod|administration	Distribution of cytochrome CYP2E1 in murine liver after ethanol and acetone administration .
18326880	0	ethanol	53,60	CYP2E1	43,49	ethanol	CYP2E1	MESH:D000431	25086(Tax:10116)	Chemical	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	Distribution and differential induction of CYP2E1 by ethanol and acetone in the mesocorticolimbic system of rat .
1845601	0	ethanol	11,18	CYP2E1	108,114	ethanol	CYP2E1	MESH:D000431	25086(Tax:10116)	Chemical	Gene	system|compound|START_ENTITY system|dep|regulation regulation|nmod|cytochrome cytochrome|nummod|END_ENTITY	Microsomal ethanol oxidizing system : transcriptional and posttranscriptional regulation of cytochrome P450 , CYP2E1 .
18990514	0	ethanol	49,56	CYP2E1	19,25	ethanol	CYP2E1	MESH:D000431	25086(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY changes|dobj|effects changes|nsubj|Induction Induction|nmod|END_ENTITY	Induction of brain CYP2E1 changes the effects of ethanol on dopamine release in nucleus accumbens shell .
19477265	0	ethanol	8,15	CYP2E1	76,82	ethanol	CYP2E1	MESH:D000431	13106(Tax:10090)	Chemical	Gene	feeding|compound|START_ENTITY potentiates|nsubj|feeding potentiates|parataxis|kinase kinase|nsubj|role role|nmod|END_ENTITY	Chronic ethanol feeding potentiates Fas Jo2-induced hepatotoxicity : role of CYP2E1 and TNF-alpha and activation of JNK and P38 MAP kinase .
19900053	0	ethanol	36,43	CYP2E1	8,14	ethanol	CYP2E1	MESH:D000431	1571	Chemical	Gene	metabolism|nmod|START_ENTITY Role|nmod|metabolism Role|nmod|END_ENTITY	Role of CYP2E1 in the metabolism of ethanol in patients with liver_cirrhosis .
22288377	0	ethanol	11,18	CYP2E1	22,28	ethanol	CYP2E1	MESH:D000431	25086(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|levels levels|nummod|END_ENTITY	Effects of ethanol on CYP2E1 levels and related oxidative stress using a standard balanced diet .
22960445	0	ethanol	37,44	CYP2E1	19,25	ethanol	CYP2E1	MESH:D000431	25086(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY END_ENTITY|nmod|treatment	Induction of brain CYP2E1 by chronic ethanol treatment and related oxidative stress in hippocampus , cerebellum , and brainstem .
7802633	0	ethanol	73,80	CYP2E1	126,132	ethanol	CYP2E1	MESH:D000431	25086(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY Induction|nmod|administration Induction|dep|evidence evidence|dep|possesses possesses|nsubj|END_ENTITY	Induction of CYP2E1 in liver , kidney , brain and intestine during chronic ethanol administration and withdrawal : evidence that CYP2E1 possesses a rapid phase half-life of 6 hours or less .
7802633	0	ethanol	73,80	CYP2E1	13,19	ethanol	CYP2E1	MESH:D000431	25086(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY Induction|nmod|administration Induction|nmod|END_ENTITY	Induction of CYP2E1 in liver , kidney , brain and intestine during chronic ethanol administration and withdrawal : evidence that CYP2E1 possesses a rapid phase half-life of 6 hours or less .
8454037	0	ethanol	10,17	CYP2E1	42,48	ethanol	CYP2E1	MESH:D000431	25086(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY cytochrome|nsubj|Effect cytochrome|dobj|2E1 2E1|appos|END_ENTITY	Effect of ethanol on cytochrome P450 2E1 -LRB- CYP2E1 -RRB- , lipid peroxidation , and serum protein adduct formation in relation to liver pathology pathogenesis .
12824820	0	ethanol	22,29	CYP3A	13,18	ethanol	CYP3A	MESH:D000431	1576	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of CYP3A by ethanol in multiple in vitro and in vivo models .
11224269	0	ethanol	50,57	Catalase	0,8	ethanol	Catalase	MESH:D000431	24248(Tax:10116)	Chemical	Gene	acquisition|nmod|START_ENTITY attenuates|dobj|acquisition attenuates|nsubj|inhibition inhibition|amod|END_ENTITY	Catalase inhibition attenuates the acquisition of ethanol and saccharin-quinine consumption in laboratory_rats .
15694276	0	ethanol	50,57	Catalase	0,8	ethanol	Catalase	MESH:D000431	24248(Tax:10116)	Chemical	Gene	effects|compound|START_ENTITY blocks|dobj|effects blocks|nsubj|inhibition inhibition|amod|END_ENTITY	Catalase inhibition in the Arcuate_nucleus blocks ethanol effects on the locomotor activity of rats .
26735784	0	ethanol	111,118	Catalase	0,8	ethanol	Catalase	MESH:D000431	847	Chemical	Gene	effects|nmod|START_ENTITY mediator|nmod|effects END_ENTITY|dep|mediator	Catalase and the production of brain acetaldehyde : a possible mediator of the psychopharmacological effects of ethanol .
3145522	0	ethanol	157,164	Catalase	0,8	ethanol	Catalase	MESH:D000431	24248(Tax:10116)	Chemical	Gene	intake|compound|START_ENTITY system|nmod|intake evidence|nmod|system activity|dep|evidence activity|amod|END_ENTITY	Catalase activity measured in rats naive to ethanol correlates with later voluntary ethanol consumption : possible evidence for a biological marker system of ethanol intake .
3145522	0	ethanol	44,51	Catalase	0,8	ethanol	Catalase	MESH:D000431	24248(Tax:10116)	Chemical	Gene	correlates|compound|START_ENTITY naive|nmod|correlates rats|amod|naive measured|nmod|rats activity|acl|measured activity|amod|END_ENTITY	Catalase activity measured in rats naive to ethanol correlates with later voluntary ethanol consumption : possible evidence for a biological marker system of ethanol intake .
3145522	0	ethanol	84,91	Catalase	0,8	ethanol	Catalase	MESH:D000431	24248(Tax:10116)	Chemical	Gene	consumption|compound|START_ENTITY correlates|nmod|consumption naive|nmod|correlates rats|amod|naive measured|nmod|rats activity|acl|measured activity|amod|END_ENTITY	Catalase activity measured in rats naive to ethanol correlates with later voluntary ethanol consumption : possible evidence for a biological marker system of ethanol intake .
9309319	0	ethanol	46,53	Catalase	0,8	ethanol	Catalase	MESH:D000431	24248(Tax:10116)	Chemical	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Catalase mediates acetaldehyde formation from ethanol in fetal and neonatal rat brain .
12798973	0	ethanol	24,31	Cholecystokinin	0,15	ethanol	Cholecystokinin	MESH:D000431	101844223	Chemical	Gene	consumption|compound|START_ENTITY reduces|dobj|consumption reduces|nsubj|END_ENTITY	Cholecystokinin reduces ethanol consumption in golden_hamsters .
7291043	0	ethanol	48,55	Cholecystokinin	0,15	ethanol	Cholecystokinin	MESH:D000431	25298(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY levels|nmod|administration levels|compound|END_ENTITY	Cholecystokinin and enkephalin levels following ethanol administration in rats .
8333582	0	ethanol	37,44	Cholecystokinin	0,15	ethanol	Cholecystokinin	MESH:D000431	25298(Tax:10116)	Chemical	Gene	intake|compound|START_ENTITY inhibit|dobj|intake inhibit|nsubj|END_ENTITY	Cholecystokinin and bombesin inhibit ethanol and food intake in rats selectively bred for ethanol sensitivity .
8333582	0	ethanol	90,97	Cholecystokinin	0,15	ethanol	Cholecystokinin	MESH:D000431	25298(Tax:10116)	Chemical	Gene	sensitivity|compound|START_ENTITY bred|nmod|sensitivity rats|acl|bred inhibit|nmod|rats inhibit|nsubj|END_ENTITY	Cholecystokinin and bombesin inhibit ethanol and food intake in rats selectively bred for ethanol sensitivity .
15138758	0	ethanol	126,133	Corticotropin-releasing_factor	0,30	ethanol	Corticotropin-releasing factor	MESH:D000431	12918(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY drinking|nmod|effects decreases|dobj|drinking decreases|nsubj|overexpression overexpression|compound|END_ENTITY	Corticotropin-releasing_factor overexpression decreases ethanol drinking and increases sensitivity to the sedative effects of ethanol .
15138758	0	ethanol	56,63	Corticotropin-releasing_factor	0,30	ethanol	Corticotropin-releasing factor	MESH:D000431	12918(Tax:10090)	Chemical	Gene	drinking|compound|START_ENTITY decreases|dobj|drinking decreases|nsubj|overexpression overexpression|compound|END_ENTITY	Corticotropin-releasing_factor overexpression decreases ethanol drinking and increases sensitivity to the sedative effects of ethanol .
16876134	0	ethanol	64,71	Corticotropin-releasing_factor	0,30	ethanol	Corticotropin-releasing factor	MESH:D000431	1392	Chemical	Gene	self-administration|compound|START_ENTITY reduce|dobj|self-administration reduce|nsubj|antagonists antagonists|nummod|1 1|compound|END_ENTITY	Corticotropin-releasing_factor 1 antagonists selectively reduce ethanol self-administration in ethanol-dependent rats .
17079660	0	ethanol	92,99	Corticotropin-releasing_factor	0,30	ethanol	Corticotropin-releasing factor	MESH:D000431	81648(Tax:10116)	Chemical	Gene	self-administration|compound|START_ENTITY mediates|dobj|self-administration mediates|nsubj|END_ENTITY	Corticotropin-releasing_factor within the central nucleus of the amygdala mediates enhanced ethanol self-administration in withdrawn , ethanol-dependent rats .
19843974	0	ethanol	54,61	Corticotropin-releasing_factor	0,30	ethanol	Corticotropin-releasing factor	MESH:D000431	81648(Tax:10116)	Chemical	Gene	behavior|compound|START_ENTITY sensitization|nmod|behavior sensitization|amod|END_ENTITY	Corticotropin-releasing_factor -LRB- CRF -RRB- sensitization of ethanol withdrawal-induced anxiety-like behavior is brain site specific and mediated by CRF-1 receptors : relation to stress-induced sensitization .
2378427	0	ethanol	88,95	Corticotropin-releasing_factor	0,30	ethanol	Corticotropin-releasing factor	MESH:D000431	81648(Tax:10116)	Chemical	Gene	preference|nmod|START_ENTITY altered|nmod|preference altered|nsubjpass|END_ENTITY	Corticotropin-releasing_factor is altered in brains of animals with high preference for ethanol .
26869199	0	ethanol	78,85	Cystic_fibrosis_transmembrane_conductance_regulator	0,51	ethanol	Cystic fibrosis transmembrane conductance regulator	MESH:D000431	12638(Tax:10090)	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Cystic_fibrosis_transmembrane_conductance_regulator activation by the solvent ethanol : implications for topical drug delivery .
11150351	0	ethanol	24,31	DARPP-32	35,43	ethanol	DARPP-32	MESH:D000431	19049(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|mice mice|compound|END_ENTITY	Motivational effects of ethanol in DARPP-32 knock-out mice .
15770104	0	ethanol	10,17	DARPP-32	21,29	ethanol	DARPP-32	MESH:D000431	19049(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Effect of ethanol on DARPP-32 phosphorylation in transgenic_mice that express human type VII adenylyl cyclase in brain .
1456170	0	ethanol	75,82	Diamine_oxidase	0,15	ethanol	Diamine oxidase	MESH:D000431	65029(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Diamine_oxidase activity and related substrates in rat liver after chronic ethanol feeding .
25764479	0	ethanol	108,115	Dopamine_D3_Receptor	14,34	ethanol	Dopamine D3 Receptor	MESH:D000431	13490(Tax:10090)	Chemical	Gene	consumption|nmod|START_ENTITY decreases|dobj|consumption decreases|nsubj|SB-277011-A SB-277011-A|compound|END_ENTITY	The Selective Dopamine_D3_Receptor Antagonist SB-277011-A significantly decreases binge-like consumption of ethanol in C57BL/J6 Mice .
12377360	0	ethanol	71,78	Dopamine_D3_receptor	0,20	ethanol	Dopamine D3 receptor	MESH:D000431	13490(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|amod|END_ENTITY	Dopamine_D3_receptor antagonist effects on the motivational effects of ethanol .
12873629	0	ethanol	67,74	Dopamine_D3_receptor	0,20	ethanol	Dopamine D3 receptor	MESH:D000431	13490(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nsubj|mice mice|amod|END_ENTITY	Dopamine_D3_receptor knockout mice and the motivational effects of ethanol .
24584330	0	ethanol	38,45	Dopamine_D3_receptor	0,20	ethanol	Dopamine D3 receptor	MESH:D000431	13490(Tax:10090)	Chemical	Gene	consumption|compound|START_ENTITY necessary|nmod|consumption necessary|nsubj|END_ENTITY	Dopamine_D3_receptor is necessary for ethanol consumption : an approach with buspirone .
9536005	0	ethanol	15,22	E2_and_leukotriene_B4	75,96	ethanol	E2 and leukotriene B4	MESH:D000431	299201(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of ethanol and acetaldehyde on the metabolism of prostaglandin E2_and_leukotriene_B4 in isolated rat hepatocytes .
23178662	0	ethanol	57,64	ERK1	0,4	ethanol	ERK1	MESH:D000431	26417(Tax:10090)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	ERK1 - and TBK1-targeted anti-inflammatory activity of an ethanol extract of Dryopteris crassirhizoma .
25716198	0	ethanol	101,108	Enkephalin	0,10	ethanol	Enkephalin	MESH:D000431	29237(Tax:10116)	Chemical	Gene	behavior|amod|START_ENTITY inhibits|dobj|behavior inhibits|nsubj|N N|compound|END_ENTITY	Enkephalin analog , cyclo -LSB- N -LRB- __ -RRB- , N -LRB- b -RRB- - carbonyl-D-Lys -LRB- 2 -RRB- , Dap -LRB- 5 -RRB- -RSB- _ enkephalinamide -LRB- cUENK6 -RRB- , inhibits the ethanol withdrawal-induced anxiety-like behavior in rats .
25716198	0	ethanol	101,108	Enkephalin	0,10	ethanol	Enkephalin	MESH:D000431	29237(Tax:10116)	Chemical	Gene	behavior|amod|START_ENTITY inhibits|dobj|behavior inhibits|nsubj|N N|compound|END_ENTITY	Enkephalin analog , cyclo -LSB- N -LRB- __ -RRB- , N -LRB- b -RRB- - carbonyl-D-Lys -LRB- 2 -RRB- , Dap -LRB- 5 -RRB- -RSB- _ enkephalinamide -LRB- cUENK6 -RRB- , inhibits the ethanol withdrawal-induced anxiety-like behavior in rats .
3955217	0	ethanol	90,97	Enkephalin	1,11	ethanol	Enkephalin	MESH:D000431	29237(Tax:10116)	Chemical	Gene	-RSB-|compound|START_ENTITY undergoing|nmod|-RSB- rats|acl|undergoing brain|nmod|rats sections|nmod|brain content|nmod|sections END_ENTITY|amod|content	-LSB- Enkephalin content in sections of the brain of rats undergoing intrauterine exposures to ethanol -RSB- .
11057525	0	ethanol	70,77	Fos	37,40	ethanol	Fos	MESH:D000431	314322(Tax:10116)	Chemical	Gene	withdrawal|compound|START_ENTITY expression|nmod|withdrawal expression|compound|END_ENTITY	Enhanced ultrasonic vocalization and Fos protein expression following ethanol withdrawal : effects of flumazenil .
18358631	0	ethanol	6,13	Fos	22,25	ethanol	Fos	MESH:D000431	314322(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Acute ethanol induces Fos in GABAergic and non-GABAergic forebrain neurons : a double-labeling study in the medial prefrontal cortex and extended amygdala .
26057446	0	ethanol	9,16	Fos	49,52	ethanol	Fos	MESH:D000431	314322(Tax:10116)	Chemical	Gene	alters|compound|START_ENTITY ethanol-induced|nsubj|alters ethanol-induced|dobj|activity activity|compound|END_ENTITY	Prenatal ethanol exposure alters ethanol-induced Fos immunoreactivity and dopaminergic activity in the mesocorticolimbic pathway of the adolescent brain .
7648269	0	ethanol	82,89	Fos	34,37	ethanol	Fos	MESH:D000431	314322(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY brain|nmod|administration immunoreactivity|nmod|brain immunoreactivity|nsubj|Activation Activation|nmod|END_ENTITY	Activation and desensitization of Fos immunoreactivity in the rat brain following ethanol administration .
2990958	0	ethanol	20,27	GABA_receptor	46,59	ethanol	GABA receptor	MESH:D000431	11337	Chemical	Gene	administration|compound|START_ENTITY administration|nmod|END_ENTITY	The effect of acute ethanol administration on GABA_receptor binding in cerebellum and hypothalamus .
19841904	0	ethanol	66,73	GAT-1	88,93	ethanol	GAT-1	MESH:D000431	232333(Tax:10090)	Chemical	Gene	immunoreactivity|compound|START_ENTITY immunoreactivity|compound|END_ENTITY	Administration of neurotoxic doses of MDMA reduces sensitivity to ethanol and increases GAT-1 immunoreactivity in mice striatum .
6688386	0	ethanol	21,28	GLI	58,61	ethanol	GLI	MESH:D000431	140589(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY effects|nmod|administration END_ENTITY|nsubj|effects	-LSB- The effects of oral ethanol administration on plasma gut GLI in rats -RSB- .
8979253	0	ethanol	11,18	GLUT1	22,27	ethanol	GLUT1	MESH:D000431	24778(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	Effects of ethanol on GLUT1 protein and gene expression in rat astrocytes .
10683205	0	ethanol	24,31	GLYT1	78,83	ethanol	GLYT1	MESH:D000431	6536	Chemical	Gene	effects|nmod|START_ENTITY mediated|nsubj|effects mediated|nmod|END_ENTITY	Differential effects of ethanol on glycine uptake mediated by the recombinant GLYT1 and GLYT2 glycine transporters .
19860804	0	ethanol	118,125	Galanin	0,7	ethanol	Galanin	MESH:D000431	14419(Tax:10090)	Chemical	Gene	intake|compound|START_ENTITY stimulate|dobj|intake peptides|acl:relcl|stimulate disturbances|nmod|peptides show|dobj|disturbances show|nsubj|mice mice|compound|END_ENTITY	Galanin knockout mice show disturbances in ethanol consumption and expression of hypothalamic peptides that stimulate ethanol intake .
19860804	0	ethanol	43,50	Galanin	0,7	ethanol	Galanin	MESH:D000431	14419(Tax:10090)	Chemical	Gene	consumption|compound|START_ENTITY disturbances|nmod|consumption show|dobj|disturbances show|nsubj|mice mice|compound|END_ENTITY	Galanin knockout mice show disturbances in ethanol consumption and expression of hypothalamic peptides that stimulate ethanol intake .
10085778	0	ethanol	40,47	Gastrin	0,7	ethanol	Gastrin	MESH:D000431	25320(Tax:10116)	Chemical	Gene	producing|nmod|START_ENTITY END_ENTITY|acl|producing	Gastrin producing G-cells after chronic ethanol and low protein nutrition .
4835510	0	ethanol	19,26	Gastrin	0,7	ethanol	Gastrin	MESH:D000431	2520	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|END_ENTITY	Gastrin release by ethanol in man and in dogs .
12871650	9	ethanol	1611,1618	GluR1	1622,1627	ethanol	GluR1	MESH:D000431	14799(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	In summary , although the loss of a hypothermic effect of ethanol in GluR1 - / - mice indicates a critical role for the AMPA receptors in this effect , the GluR1 subunit of the AMPA receptor does not seem to play a critical role in the etiology of alcohol_dependence .
20060435	0	ethanol	25,32	GnRH	36,40	ethanol	GnRH	MESH:D000431	25194(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|compound|END_ENTITY	Time-dependent effect of ethanol on GnRH and GnRH_receptor mRNA expression in hypothalamus and testis of adult and pubertal rats .
12540785	0	ethanol	23,30	Hfe	34,37	ethanol	Hfe	MESH:D000431	15216(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Uroporphyria caused by ethanol in Hfe -LRB- - / - -RRB- mice as a model for porphyria_cutanea_tarda .
24894977	0	ethanol	81,88	Hsf1	119,123	ethanol	Hsf1	MESH:D000431	852806(Tax:4932)	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	CK2-dependent inhibitory phosphorylation is relieved by Ppt1 phosphatase for the ethanol stress-specific activation of Hsf1 in Saccharomyces_cerevisiae .
17545099	0	ethanol	44,51	IFN-gamma	133,142	ethanol	IFN-gamma	MESH:D000431	100860815	Chemical	Gene	START_ENTITY|nmod|activity activity|appos|END_ENTITY	Effects of Saussurea lappa roots extract in ethanol on leukocyte phagocytic activity , lymphocyte proliferation and interferon-gamma -LRB- IFN-gamma -RRB- .
26434683	0	ethanol	9,16	IGF-1	123,128	ethanol	IGF-1	MESH:D000431	24482(Tax:10116)	Chemical	Gene	increases|compound|START_ENTITY osteoarthritis|nsubj|increases osteoarthritis|dobj|END_ENTITY	Prenatal ethanol exposure increases osteoarthritis susceptibility in female rat offspring by programming a low-functioning IGF-1 signaling pathway .
7978107	8	ethanol	966,973	IGF-1	942,947	ethanol	IGF-1	MESH:D000431	3479	Chemical	Gene	absence|nmod|START_ENTITY END_ENTITY|nmod|absence	However , 72-hr ethanol pretreatment of trophoblasts inhibited Na -LRB- + -RRB- - dependent AIB uptake under stimulation by insulin or IGF-1 in the absence of ethanol .
8749812	0	ethanol	10,17	IGF-1	156,161	ethanol	IGF-1	MESH:D000431	24482(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|correlation correlation|nmod|END_ENTITY	Effect of ethanol on the synthesis of insulin-like_growth_factor_1 -LRB- IGF-1 -RRB- and the IGF-1_receptor in late prepubertal female rats : a correlation with serum IGF-1 .
8749812	0	ethanol	10,17	IGF-1	68,73	ethanol	IGF-1	MESH:D000431	24482(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|synthesis synthesis|nmod|insulin-like_growth_factor_1 insulin-like_growth_factor_1|appos|END_ENTITY	Effect of ethanol on the synthesis of insulin-like_growth_factor_1 -LRB- IGF-1 -RRB- and the IGF-1_receptor in late prepubertal female rats : a correlation with serum IGF-1 .
17640761	0	ethanol	33,40	IGFBP-1	17,24	ethanol	IGFBP-1	MESH:D000431	3484	Chemical	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	Stabilization of IGFBP-1 mRNA by ethanol in hepatoma cells involves the JNK pathway .
26006114	0	ethanol	34,41	Insulin	0,7	ethanol	Insulin	MESH:D000431	3630	Chemical	Gene	metabolism|compound|START_ENTITY alters|dep|metabolism alters|amod|END_ENTITY	Insulin resistance alters hepatic ethanol metabolism : studies in mice and children with non-alcoholic_fatty_liver_disease .
26006114	0	ethanol	34,41	Insulin	0,7	ethanol	Insulin	MESH:D000431	3630	Chemical	Gene	metabolism|compound|START_ENTITY alters|dep|metabolism alters|amod|END_ENTITY	Insulin resistance alters hepatic ethanol metabolism : studies in mice and children with non-alcoholic_fatty_liver_disease .
15680252	0	ethanol	66,73	JNK	58,61	ethanol	JNK	MESH:D000431	116554(Tax:10116)	Chemical	Gene	c-Jun_N-terminal_kinase|nmod|START_ENTITY c-Jun_N-terminal_kinase|appos|END_ENTITY	Pro- and anti-apoptotic roles of c-Jun_N-terminal_kinase -LRB- JNK -RRB- in ethanol and acetaldehyde exposed rat hepatocytes .
17640761	0	ethanol	33,40	JNK	72,75	ethanol	JNK	MESH:D000431	5599	Chemical	Gene	mRNA|nmod|START_ENTITY Stabilization|nmod|mRNA involves|nsubj|Stabilization involves|dobj|pathway pathway|compound|END_ENTITY	Stabilization of IGFBP-1 mRNA by ethanol in hepatoma cells involves the JNK pathway .
23227189	0	ethanol	62,69	JNK	0,3	ethanol	JNK	MESH:D000431	26419(Tax:10090)	Chemical	Gene	sensitivity|compound|START_ENTITY controlled|nmod|sensitivity controlled|nsubjpass|activation activation|compound|END_ENTITY	JNK pathway activation is controlled by Tao/TAOK3 to modulate ethanol sensitivity .
25244799	0	ethanol	35,42	JNK	64,67	ethanol	JNK	MESH:D000431	116554(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of activation of ALDH2 by ethanol on the expression of JNK in kidney of diabetic rats -RSB- .
18926887	2	ethanol	337,344	L1CAM	311,316	ethanol	L1CAM	MESH:D000431	50687(Tax:10116)	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	The resemblance suggests that L1CAM may be a target for ethanol , and consistent with this idea , ethanol can inhibit L1CAM adhesion in cell lines and L1CAM-mediated outgrowth and signaling in cerebellar granule neurons .
2654323	0	ethanol	18,25	LH-releasing_hormone	40,60	ethanol	LH-releasing hormone	MESH:D000431	25194(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|release release|nmod|END_ENTITY	In-vivo effect of ethanol on release of LH-releasing_hormone and LH in rats .
2292236	0	ethanol	23,30	LHRH	43,47	ethanol	LHRH	MESH:D000431	25194(Tax:10116)	Chemical	Gene	exposure|compound|START_ENTITY exposure|nmod|END_ENTITY	The effect of in vitro ethanol exposure on LHRH release from perifused rat hypothalami .
6373351	0	ethanol	11,18	LHRH	74,78	ethanol	LHRH	MESH:D000431	25194(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of ethanol on hypothalamic luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- in the male rat .
25176312	0	ethanol	34,41	Lmo3	45,49	ethanol	Lmo3	MESH:D000431	109593(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Increased behavioral responses to ethanol in Lmo3 knockout mice .
10440485	0	ethanol	9,16	NGF	28,31	ethanol	NGF	MESH:D000431	18049(Tax:10090)	Chemical	Gene	effects|compound|START_ENTITY effects|nmod|END_ENTITY	Prenatal ethanol effects on NGF level , NPY and ChAT immunoreactivity in mouse entorhinal cortex : a preliminary study .
8436061	0	ethanol	22,29	NGF	46,49	ethanol	NGF	MESH:D000431	18049(Tax:10090)	Chemical	Gene	intake|compound|START_ENTITY effect|nmod|intake effect|nmod|level level|compound|END_ENTITY	The effect of chronic ethanol intake on brain NGF level and on NGF-target tissues of adult mice .
19878433	0	ethanol	98,105	P2X4	109,113	ethanol	P2X4	MESH:D000431	398206(Tax:8355)	Chemical	Gene	START_ENTITY|nmod|receptors receptors|nummod|END_ENTITY	A point mutation in the ectodomain-transmembrane 2 interface eliminates the inhibitory effects of ethanol in P2X4 receptors .
17681070	0	ethanol	42,49	PC3	53,56	ethanol	PC3	MESH:D000431	5122	Chemical	Gene	START_ENTITY|nmod|cells cells|nummod|END_ENTITY	Effects of direct injection of dehydrated ethanol on PC3 human prostate_cancer cells in nude_mice : preliminary study .
17469934	0	ethanol	49,56	PKCepsilon	60,70	ethanol	PKCepsilon	MESH:D000431	18754(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Increased sensitivity to the aversive effects of ethanol in PKCepsilon null mice revealed by place conditioning .
17157717	0	ethanol	69,76	PKCgamma	90,98	ethanol	PKCgamma	MESH:D000431	18752(Tax:10090)	Chemical	Gene	treatment|compound|START_ENTITY treatment|nmod|mice mice|compound|END_ENTITY	Microarray analysis identifies cerebellar genes sensitive to chronic ethanol treatment in PKCgamma mice .
9665316	0	ethanol	23,30	POMC	57,61	ethanol	POMC	MESH:D000431	24664(Tax:10116)	Chemical	Gene	exposure|compound|START_ENTITY exposure|nmod|END_ENTITY	The effect of an acute ethanol exposure on the rat brain POMC opiopeptide system .
21309945	0	ethanol	37,44	PSD-95	17,23	ethanol	PSD-95	MESH:D000431	13385(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	A novel role for PSD-95 in mediating ethanol intoxication , drinking and place preference .
1471770	0	ethanol	104,111	Proopiomelanocortin	0,19	ethanol	Proopiomelanocortin	MESH:D000431	24664(Tax:10116)	Chemical	Gene	made|nmod|START_ENTITY rats|acl|made hypothalamus|nmod|rats decreased|nmod|hypothalamus decreased|nsubjpass|RNA RNA|compound|END_ENTITY	Proopiomelanocortin messenger RNA is decreased in the mediobasal hypothalamus of rats made dependent on ethanol .
11861805	0	ethanol	31,38	Protein_kinase_C	0,16	ethanol	Protein kinase C	MESH:D000431	24681(Tax:10116)	Chemical	Gene	inhibition|compound|START_ENTITY modulation|nmod|inhibition modulation|amod|END_ENTITY	Protein_kinase_C modulation of ethanol inhibition of glycine-activated current in dissociated neurons of rat ventral tegmental area .
8252418	0	ethanol	75,82	Protein_kinase_C	0,16	ethanol	Protein kinase C	MESH:D000431	24681(Tax:10116)	Chemical	Gene	isozymes|nmod|START_ENTITY isozymes|nsubj|END_ENTITY	Protein_kinase_C isozymes that mediate enhancement of neurite outgrowth by ethanol and phorbol_esters in PC12 cells .
10617678	0	ethanol	78,85	Protein_kinase_C_epsilon	0,24	ethanol	Protein kinase C epsilon	MESH:D000431	29340(Tax:10116)	Chemical	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Protein_kinase_C_epsilon mediates up-regulation of N-type calcium channels by ethanol .
12646286	0	ethanol	40,47	Protein_kinase_C_epsilon	0,24	ethanol	Protein kinase C epsilon	MESH:D000431	29340(Tax:10116)	Chemical	Gene	potentiation|compound|START_ENTITY involved|nmod|potentiation involved|nsubjpass|END_ENTITY	Protein_kinase_C_epsilon is involved in ethanol potentiation of glycine-gated Cl -LRB- - -RRB- current in rat neurons of ventral tegmental area .
463581	0	ethanol	39,46	Renin	0,5	ethanol	Renin	MESH:D000431	5972	Chemical	Gene	intoxication|compound|START_ENTITY END_ENTITY|nmod|intoxication	Renin , aldosterone and cortisol during ethanol intoxication and hangover .
26170296	0	ethanol	15,22	Rsu1	0,4	ethanol	Rsu1	MESH:D000431	34774(Tax:7227)	Chemical	Gene	consumption|compound|START_ENTITY regulates|dobj|consumption regulates|nsubj|END_ENTITY	Rsu1 regulates ethanol consumption in Drosophila and humans .
24833709	0	ethanol	25,32	Sestrin3	36,44	ethanol	Sestrin3	MESH:D000431	75747(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The inhibitory effect of ethanol on Sestrin3 in the pathogenesis of ethanol-induced liver_injury .
11696671	0	ethanol	17,24	StAR	68,72	ethanol	StAR	MESH:D000431	25557(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Acute effects of ethanol on steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- in the prepubertal rat ovary .
3795479	1	ethanol	197,204	T-2588	99,105	ethanol	T-2588	MESH:D000431	1070815(Tax:209261)	Chemical	Gene	activities|nmod|START_ENTITY activities|amod|END_ENTITY	Influence of the consecutive administration of T-2588 on hepatic alcohol dehydrogenase and aldehyde dehydrogenase activities and blood levels of ethanol and acetaldehyde -RSB- .
12198406	0	ethanol	11,18	TGF_beta	56,64	ethanol	TGF beta	MESH:D000431	7040	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of ethanol and transforming_growth_factor_beta -LRB- TGF_beta -RRB- on neuronal proliferation and nCAM expression .
25601712	0	ethanol	6,13	TRPC6	47,52	ethanol	TRPC6	MESH:D000431	7225	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|stimulating stimulating|dobj|END_ENTITY	Acute ethanol induces apoptosis by stimulating TRPC6 via elevation of superoxide in oxygenated podocytes .
9665314	0	ethanol	103,110	Tumor_necrosis_factor-alpha	0,27	ethanol	Tumor necrosis factor-alpha	MESH:D000431	24835(Tax:10116)	Chemical	Gene	exposed|nmod|START_ENTITY internalization|acl|exposed internalization|amod|END_ENTITY	Tumor_necrosis_factor-alpha internalization and degradation by isolated hepatocytes of rats exposed to ethanol .
18923141	0	ethanol	17,24	UNC-18	0,6	ethanol	UNC-18	MESH:D000431	181030(Tax:6239)	Chemical	Gene	sensitivity|compound|START_ENTITY modulates|dobj|sensitivity modulates|nsubj|END_ENTITY	UNC-18 modulates ethanol sensitivity in Caenorhabditis_elegans .
1407268	0	ethanol	24,31	acetylcholinesterase	62,82	ethanol	acetylcholinesterase	MESH:D000431	43	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Differential effects of ethanol on membrane-bound and soluble acetylcholinesterase from sarcoplasmic reticulum membranes .
1999262	0	ethanol	38,45	acetylcholinesterase	49,69	ethanol	acetylcholinesterase	MESH:D000431	43	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Biochemical studies of the actions of ethanol on acetylcholinesterase activity : ethanol-enzyme-solvent interaction .
20884336	0	ethanol	79,86	acetylcholinesterase	32,52	ethanol	acetylcholinesterase	MESH:D000431	114549(Tax:7955)	Chemical	Gene	exposure|compound|START_ENTITY induced|nmod|exposure activity|acl|induced activity|amod|END_ENTITY	Taurine prevents enhancement of acetylcholinesterase activity induced by acute ethanol exposure and decreases the level of markers of oxidative stress in zebrafish brain .
3767274	0	ethanol	10,17	acetylcholinesterase	33,53	ethanol	acetylcholinesterase	MESH:D000431	43	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|compound|END_ENTITY	Effect of ethanol on erythrocyte acetylcholinesterase activity .
6697258	0	ethanol	9,16	acetylcholinesterase	79,99	ethanol	acetylcholinesterase	MESH:D000431	83817(Tax:10116)	Chemical	Gene	exposure|compound|START_ENTITY alters|nsubj|exposure alters|dobj|reorganization reorganization|nmod|END_ENTITY	Prenatal ethanol exposure alters the post-lesion reorganization -LRB- sprouting -RRB- of acetylcholinesterase staining in the dentate gyrus of adult rats .
7582849	0	ethanol	84,91	acetylcholinesterase	14,34	ethanol	acetylcholinesterase	MESH:D000431	43	Chemical	Gene	consumption|compound|START_ENTITY erythrocytes|nmod|consumption ATP-ase|nmod|erythrocytes Activities|dep|ATP-ase Activities|nmod|END_ENTITY	Activities of acetylcholinesterase and NA + , K + - ATP-ase in human erythrocytes after ethanol consumption .
8293290	0	ethanol	19,26	acetylcholinesterase	45,65	ethanol	acetylcholinesterase	MESH:D000431	83817(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY administration|nmod|activity activity|amod|END_ENTITY	Effects of chronic ethanol administration on acetylcholinesterase activity in the somatosensory cortex and basal forebrain of the rat .
11445165	0	ethanol	75,82	alcohol_dehydrogenase	6,27	ethanol	alcohol dehydrogenase	MESH:D000431	13909458	Chemical	Gene	use|dobj|START_ENTITY able|xcomp|use END_ENTITY|xcomp|able	Novel alcohol_dehydrogenase activity in a mutant of Salmonella able to use ethanol as sole carbon source .
11711778	0	ethanol	84,91	alcohol_dehydrogenase	14,35	ethanol	alcohol dehydrogenase	MESH:D000431	78959(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY expression|nmod|treatment enhanced|dobj|expression enhanced|nsubj|Inhibition Inhibition|nmod|blocks blocks|amod|END_ENTITY	Inhibition of alcohol_dehydrogenase blocks enhanced Gi-protein expression following ethanol treatment in experimental hepatocellular_carcinoma in vitro .
12878915	0	ethanol	146,153	alcohol_dehydrogenase	26,47	ethanol	alcohol dehydrogenase	MESH:D000431	58810(Tax:10090)	Chemical	Gene	ingestion|compound|START_ENTITY exacerbates|nmod|ingestion exacerbates|nsubj|overexpression overexpression|nmod|END_ENTITY	Cardiac overexpression of alcohol_dehydrogenase exacerbates cardiac contractile_dysfunction , lipid peroxidation , and protein_damage after chronic ethanol ingestion .
14718645	0	ethanol	117,124	alcohol_dehydrogenase	40,61	ethanol	alcohol dehydrogenase	MESH:D000431	10327	Chemical	Gene	based|nmod|START_ENTITY based|nsubj|Incorporation Incorporation|nmod|control control|nmod|END_ENTITY	Incorporation of the genetic control of alcohol_dehydrogenase into a physiologically based pharmacokinetic model for ethanol in humans .
15271077	0	ethanol	103,110	alcohol_dehydrogenase	55,76	ethanol	alcohol dehydrogenase	MESH:D000431	3771877(Tax:7227)	Chemical	Gene	tolerance|compound|START_ENTITY results|nmod|tolerance results|nsubj|reduction reduction|nmod|bias bias|nmod|gene gene|compound|END_ENTITY	Experimental reduction of codon bias in the Drosophila alcohol_dehydrogenase gene results in decreased ethanol tolerance of adult flies .
15713978	0	ethanol	89,96	alcohol_dehydrogenase	25,46	ethanol	alcohol dehydrogenase	MESH:D000431	78959(Tax:10116)	Chemical	Gene	exposed|nmod|START_ENTITY development|acl|exposed development|nmod|END_ENTITY	Postnatal development of alcohol_dehydrogenase in liver and intestine of rats exposed to ethanol in utero .
15808017	0	ethanol	23,30	alcohol_dehydrogenase	73,94	ethanol	alcohol dehydrogenase	MESH:D000431	10327	Chemical	Gene	quantification|nmod|START_ENTITY quantification|nmod|method method|compound|END_ENTITY	Fast quantification of ethanol in whole blood specimens by the enzymatic alcohol_dehydrogenase method .
18377926	0	ethanol	68,75	alcohol_dehydrogenase	26,47	ethanol	alcohol dehydrogenase	MESH:D000431	58810(Tax:10090)	Chemical	Gene	myocardial_dysfunction|compound|START_ENTITY exacerbates|dobj|myocardial_dysfunction exacerbates|nsubj|overexpression overexpression|nmod|END_ENTITY	Cardiac overexpression of alcohol_dehydrogenase exacerbates chronic ethanol ingestion-induced myocardial_dysfunction and hypertrophy : role of insulin signaling and ER stress .
1877746	0	ethanol	62,69	alcohol_dehydrogenase	115,136	ethanol	alcohol dehydrogenase	MESH:D000431	10327	Chemical	Gene	inhibition|compound|START_ENTITY involving|dobj|inhibition involving|nmod|step step|amod|END_ENTITY	A hypothetical mechanism for fetal_alcohol_syndrome involving ethanol inhibition of retinoic_acid synthesis at the alcohol_dehydrogenase step .
18966751	0	ethanol	27,34	alcohol_dehydrogenase	62,83	ethanol	alcohol dehydrogenase	MESH:D000431	10327	Chemical	Gene	biosensor|nmod|START_ENTITY biosensor|nmod|END_ENTITY	Amperometric biosensor for ethanol based on immobilization of alcohol_dehydrogenase on a nickel_hexacyanoferrate modified microband gold electrode .
1898355	0	ethanol	57,64	alcohol_dehydrogenase	18,39	ethanol	alcohol dehydrogenase	MESH:D000431	78959(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY importance|nmod|metabolism importance|nmod|END_ENTITY	The importance of alcohol_dehydrogenase in regulation of ethanol metabolism in rat liver cells .
19616932	0	ethanol	35,42	alcohol_dehydrogenase	62,83	ethanol	alcohol dehydrogenase	MESH:D000431	10327	Chemical	Gene	biosensor|compound|START_ENTITY biosensor|acl|based based|nmod|3 3|amod|functionalized functionalized|amod|END_ENTITY	Electrogenerated chemiluminescence ethanol biosensor based on alcohol_dehydrogenase functionalized Ru -LRB- bpy -RRB- 3 -LRB- 2 + -RRB- doped silica nanoparticles .
201176	0	ethanol	144,151	alcohol_dehydrogenase	12,33	ethanol	alcohol dehydrogenase	MESH:D000431	10327	Chemical	Gene	treatment|nmod|START_ENTITY due|nmod|treatment metabolism|xcomp|due metabolism|nsubj|role role|nmod|END_ENTITY	The role of alcohol_dehydrogenase in microsomal ethanol oxidation and the adaptive increase in ethanol metabolism due to chronic treatment with ethanol .
201176	0	ethanol	48,55	alcohol_dehydrogenase	12,33	ethanol	alcohol dehydrogenase	MESH:D000431	10327	Chemical	Gene	oxidation|compound|START_ENTITY END_ENTITY|nmod|oxidation	The role of alcohol_dehydrogenase in microsomal ethanol oxidation and the adaptive increase in ethanol metabolism due to chronic treatment with ethanol .
20585647	0	ethanol	96,103	alcohol_dehydrogenase	23,44	ethanol	alcohol dehydrogenase	MESH:D000431	58810(Tax:10090)	Chemical	Gene	challenge|compound|START_ENTITY myocardial_dysfunction|nmod|challenge accentuated|dobj|myocardial_dysfunction accentuated|nsubj|Involvement Involvement|nmod|AMPK AMPK|nmod|END_ENTITY	Involvement of AMPK in alcohol_dehydrogenase accentuated myocardial_dysfunction following acute ethanol challenge in mice .
20724102	0	ethanol	44,51	alcohol_dehydrogenase	149,170	ethanol	alcohol dehydrogenase	MESH:D000431	78959(Tax:10116)	Chemical	Gene	metabolism|nmod|START_ENTITY Establishment|nmod|metabolism Establishment|dep|analysis analysis|acl|using using|dobj|equations equations|nmod|END_ENTITY	Establishment of steady-state metabolism of ethanol in perfused rat liver : the quantitative analysis using kinetic mechanism-based rate equations of alcohol_dehydrogenase .
21147339	0	ethanol	116,123	alcohol_dehydrogenase	27,48	ethanol	alcohol dehydrogenase	MESH:D000431	10327	Chemical	Gene	determination|nmod|START_ENTITY electrode|nmod|determination electrode|amod|END_ENTITY	Toluidine blue adsorbed on alcohol_dehydrogenase modified glassy carbon electrode for voltammetric determination of ethanol .
22315566	0	ethanol	54,61	alcohol_dehydrogenase	18,39	ethanol	alcohol dehydrogenase	MESH:D000431	10327	Chemical	Gene	determination|compound|START_ENTITY biosensor|nmod|determination biosensor|amod|END_ENTITY	Development of an alcohol_dehydrogenase biosensor for ethanol determination with toluidine_blue_O covalently attached to a cellulose_acetate modified electrode .
2712574	0	ethanol	15,22	alcohol_dehydrogenase	100,121	ethanol	alcohol dehydrogenase	MESH:D000431	10327	Chemical	Gene	system|compound|START_ENTITY mediates|nsubj|system mediates|nmod|ethanol ethanol|nmod|deermice deermice|acl|lacking lacking|dobj|END_ENTITY	The microsomal ethanol oxidizing system mediates metabolic tolerance to ethanol in deermice lacking alcohol_dehydrogenase .
2712574	0	ethanol	72,79	alcohol_dehydrogenase	100,121	ethanol	alcohol dehydrogenase	MESH:D000431	10327	Chemical	Gene	START_ENTITY|nmod|deermice deermice|acl|lacking lacking|dobj|END_ENTITY	The microsomal ethanol oxidizing system mediates metabolic tolerance to ethanol in deermice lacking alcohol_dehydrogenase .
2773067	0	ethanol	23,30	alcohol_dehydrogenase	57,78	ethanol	alcohol dehydrogenase	MESH:D000431	78959(Tax:10116)	Chemical	Gene	action|nmod|START_ENTITY action|dep|role role|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- The harmful action of ethanol on the liver : the role of alcohol_dehydrogenase and aldehyde dehydrogenase -RSB- .
2925622	0	ethanol	24,31	alcohol_dehydrogenase	99,120	ethanol	alcohol dehydrogenase	MESH:D000431	58810(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|acl|lacking lacking|dobj|END_ENTITY	Dehydrogenase-dependent ethanol metabolism in deer mice -LRB- Peromyscus maniculatus -RRB- lacking cytosolic alcohol_dehydrogenase .
2937407	0	ethanol	20,27	alcohol_dehydrogenase	71,92	ethanol	alcohol dehydrogenase	MESH:D000431	10327	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|nmod|END_ENTITY	Interaction between ethanol metabolism and mixed-function oxidation in alcohol_dehydrogenase positive and negative deermice .
3064640	0	ethanol	82,89	alcohol_dehydrogenase	49,70	ethanol	alcohol dehydrogenase	MESH:D000431	10327	Chemical	Gene	implications|compound|START_ENTITY effect|nmod|implications Degradation|dep|effect Degradation|nmod|aliphatic_alcohols aliphatic_alcohols|nmod|END_ENTITY	Degradation of aliphatic_alcohols by human liver alcohol_dehydrogenase : effect of ethanol and pharmacokinetic implications .
3122352	0	ethanol	88,95	alcohol_dehydrogenase	24,45	ethanol	alcohol dehydrogenase	MESH:D000431	3771877(Tax:7227)	Chemical	Gene	toxicity|nmod|START_ENTITY END_ENTITY|nmod|toxicity	Effects of differential alcohol_dehydrogenase activity on the developmental toxicity of ethanol in Drosophila_melanogaster .
3127555	0	ethanol	38,45	alcohol_dehydrogenase	13,34	ethanol	alcohol dehydrogenase	MESH:D000431	3771877(Tax:7227)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of alcohol_dehydrogenase by ethanol in Drosophila_melanogaster .
3142528	0	ethanol	31,38	alcohol_dehydrogenase	86,107	ethanol	alcohol dehydrogenase	MESH:D000431	3771877(Tax:7227)	Chemical	Gene	oxidation|compound|START_ENTITY Kinetics|nmod|oxidation catalyzed|nsubj|Kinetics catalyzed|nmod|variants variants|nmod|END_ENTITY	Kinetics and thermodynamics of ethanol oxidation catalyzed by genetic variants of the alcohol_dehydrogenase from Drosophila_melanogaster and D. _ simulans .
3158799	0	ethanol	71,78	alcohol_dehydrogenase	21,42	ethanol	alcohol dehydrogenase	MESH:D000431	3771877(Tax:7227)	Chemical	Gene	oxidation|compound|START_ENTITY function|dep|oxidation function|nmod|END_ENTITY	Dual function of the alcohol_dehydrogenase of Drosophila_melanogaster : ethanol and acetaldehyde oxidation by two allozymes ADH-71k and ADH-F .
3160369	0	ethanol	11,18	alcohol_dehydrogenase	53,74	ethanol	alcohol dehydrogenase	MESH:D000431	78959(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY Effects|nmod|treatment Effects|nmod|activity activity|compound|END_ENTITY	Effects of ethanol treatment and castration on liver alcohol_dehydrogenase activity .
3296835	0	ethanol	23,30	alcohol_dehydrogenase	70,91	ethanol	alcohol dehydrogenase	MESH:D000431	78959(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY inhibits|dobj|metabolism inhibits|nmod|interaction interaction|nmod|END_ENTITY	Diethyl_ether inhibits ethanol metabolism in vivo by interaction with alcohol_dehydrogenase .
3426694	0	ethanol	28,35	alcohol_dehydrogenase	168,189	ethanol	alcohol dehydrogenase	MESH:D000431	78959(Tax:10116)	Chemical	Gene	oxidation|compound|START_ENTITY factors|nmod|oxidation determining|dobj|factors Rate|acl|determining catalyzed|nsubj|Rate catalyzed|nmod|END_ENTITY	Rate determining factors of ethanol oxidation in hepatocytes from starved and fed rats : effect of acetaldehyde concentration on the rate of NADH oxidation catalyzed by alcohol_dehydrogenase .
3427094	0	ethanol	84,91	alcohol_dehydrogenase	44,65	ethanol	alcohol dehydrogenase	MESH:D000431	10327	Chemical	Gene	oxidation|compound|START_ENTITY catalyzed|dobj|oxidation catalyzed|nsubj|isozyme isozyme|compound|END_ENTITY	Thyroid hormones selectively modulate human alcohol_dehydrogenase isozyme catalyzed ethanol oxidation .
3555347	0	ethanol	35,42	alcohol_dehydrogenase	115,136	ethanol	alcohol dehydrogenase	MESH:D000431	10327	Chemical	Gene	roles|nmod|START_ENTITY roles|acl|oxidizing oxidizing|advcl|lacking lacking|dobj|END_ENTITY	Respective roles of the microsomal ethanol oxidizing system and catalase in ethanol metabolism by deermice lacking alcohol_dehydrogenase .
3555347	0	ethanol	76,83	alcohol_dehydrogenase	115,136	ethanol	alcohol dehydrogenase	MESH:D000431	10327	Chemical	Gene	metabolism|compound|START_ENTITY system|nmod|metabolism oxidizing|dobj|system oxidizing|advcl|lacking lacking|dobj|END_ENTITY	Respective roles of the microsomal ethanol oxidizing system and catalase in ethanol metabolism by deermice lacking alcohol_dehydrogenase .
3790167	0	ethanol	19,26	alcohol_dehydrogenase	66,87	ethanol	alcohol dehydrogenase	MESH:D000431	10327	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|acl|lacking lacking|dobj|END_ENTITY	Catalase-dependent ethanol metabolism in vivo in deermice lacking alcohol_dehydrogenase .
515510	0	ethanol	89,96	alcohol_dehydrogenase	39,60	ethanol	alcohol dehydrogenase	MESH:D000431	78959(Tax:10116)	Chemical	Gene	toxicity|nmod|START_ENTITY Influence|nmod|toxicity Influence|nmod|pyrazole pyrazole|appos|inhibitor inhibitor|nmod|END_ENTITY	Influence of pyrazole , an inhibitor of alcohol_dehydrogenase on the prenatal toxicity of ethanol in the rat .
6370140	0	ethanol	26,33	alcohol_dehydrogenase	83,104	ethanol	alcohol dehydrogenase	MESH:D000431	78959(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY Kinetics|nmod|metabolism Kinetics|nmod|END_ENTITY	Kinetics of inhibition of ethanol metabolism in rats and the rate-limiting role of alcohol_dehydrogenase .
6437226	0	ethanol	11,18	alcohol_dehydrogenase	22,43	ethanol	alcohol dehydrogenase	MESH:D000431	58810(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|ethanol ethanol|amod|END_ENTITY	Effects of ethanol on alcohol_dehydrogenase and microsomal ethanol oxidative system activities in fetal mice .
6772467	0	ethanol	10,17	alcohol_dehydrogenase	53,74	ethanol	alcohol dehydrogenase	MESH:D000431	3771877(Tax:7227)	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	Effect of ethanol and isopropanol on the activity of alcohol_dehydrogenase , viability and life-span in Drosophila_melanogaster and Drosophila funebris .
6790476	0	ethanol	154,161	alcohol_dehydrogenase	30,51	ethanol	alcohol dehydrogenase	MESH:D000431	3771877(Tax:7227)	Chemical	Gene	concentrations|nmod|START_ENTITY maintained|nmod|concentrations associated|parataxis|maintained associated|nmod|locus locus|amod|END_ENTITY	Selection associated with the alcohol_dehydrogenase locus in Drosophila_melanogaster : differential survival of adults maintained on low concentrations of ethanol .
6801707	0	ethanol	19,26	alcohol_dehydrogenase	63,84	ethanol	alcohol dehydrogenase	MESH:D000431	10327	Chemical	Gene	intake|compound|START_ENTITY Effects|nmod|intake END_ENTITY|nsubj|Effects	Effects of chronic ethanol intake on isozyme patterns of liver alcohol_dehydrogenase .
6987673	3	ethanol	706,713	alcohol_dehydrogenase	867,888	ethanol	alcohol dehydrogenase	MESH:D000431	10327	Chemical	Gene	oxidized|nsubjpass|START_ENTITY oxidized|nmod|site site|nmod|END_ENTITY	Several kinetic approaches have demonstrated that ethanol and the pharmacologically active components of the digitalis glycosides are oxidized with closely similar kcat/Km values at the same site on human liver alcohol_dehydrogenase , for which they compete .
7009832	0	ethanol	144,151	alcohol_dehydrogenase	10,31	ethanol	alcohol dehydrogenase	MESH:D000431	78959(Tax:10116)	Chemical	Gene	feeding|compound|START_ENTITY effect|nmod|feeding oxidation|dep|effect oxidation|amod|END_ENTITY	Increased alcohol_dehydrogenase independent ethanol oxidation at high ethanol concentrations in isolated rat hepatocytes : the effect of chronic ethanol feeding .
7009832	0	ethanol	44,51	alcohol_dehydrogenase	10,31	ethanol	alcohol dehydrogenase	MESH:D000431	78959(Tax:10116)	Chemical	Gene	oxidation|compound|START_ENTITY oxidation|amod|END_ENTITY	Increased alcohol_dehydrogenase independent ethanol oxidation at high ethanol concentrations in isolated rat hepatocytes : the effect of chronic ethanol feeding .
7009832	0	ethanol	70,77	alcohol_dehydrogenase	10,31	ethanol	alcohol dehydrogenase	MESH:D000431	78959(Tax:10116)	Chemical	Gene	concentrations|compound|START_ENTITY oxidation|nmod|concentrations oxidation|amod|END_ENTITY	Increased alcohol_dehydrogenase independent ethanol oxidation at high ethanol concentrations in isolated rat hepatocytes : the effect of chronic ethanol feeding .
7013538	0	ethanol	48,55	alcohol_dehydrogenase	69,90	ethanol	alcohol dehydrogenase	MESH:D000431	10327	Chemical	Gene	sensitivity|nmod|START_ENTITY differences|nmod|sensitivity differences|dep|role role|nmod|isozymes isozymes|amod|END_ENTITY	Racial differences in biological sensitivity to ethanol : the role of alcohol_dehydrogenase and aldehyde_dehydrogenase isozymes .
7497088	0	ethanol	80,87	alcohol_dehydrogenase	27,48	ethanol	alcohol dehydrogenase	MESH:D000431	78959(Tax:10116)	Chemical	Gene	rats|amod|START_ENTITY serum|nmod|rats activity|nmod|serum activity|amod|END_ENTITY	The effect of endotoxin on alcohol_dehydrogenase -LRB- ADH -RRB- activity in the serum of ethanol intoxicated rats .
7501685	0	ethanol	71,78	alcohol_dehydrogenase	6,27	ethanol	alcohol dehydrogenase	MESH:D000431	78959(Tax:10116)	Chemical	Gene	intake|compound|START_ENTITY END_ENTITY|nmod|intake	Liver alcohol_dehydrogenase activity and ethanol levels during chronic ethanol intake in pregnant rats and their offspring .
7992014	1	ethanol	82,89	alcohol_dehydrogenase	93,114	ethanol	alcohol dehydrogenase	MESH:D000431	10327	Chemical	Gene	Metabolism|nmod|START_ENTITY Metabolism|nmod|-RSB- -RSB-|amod|END_ENTITY	I. Metabolism of ethanol by alcohol_dehydrogenase , cytochrome_P450IIE1_and_catalase -RSB- .
8200814	0	ethanol	119,126	alcohol_dehydrogenase	54,75	ethanol	alcohol dehydrogenase	MESH:D000431	3771877(Tax:7227)	Chemical	Gene	tolerance|compound|START_ENTITY differences|nmod|tolerance related|nmod|differences related|nsubjpass|differences differences|nmod|expression expression|nmod|END_ENTITY	Regulatory differences in developmental expression of alcohol_dehydrogenase are related to interspecies differences in ethanol tolerance of Drosophila .
8298495	0	ethanol	73,80	alcohol_dehydrogenase	11,32	ethanol	alcohol dehydrogenase	MESH:D000431	3771877(Tax:7227)	Chemical	Gene	transfer|nmod|START_ENTITY END_ENTITY|dep|transfer	Drosophila alcohol_dehydrogenase : stereoselective hydrogen transfer from ethanol .
8463515	0	ethanol	33,40	alcohol_dehydrogenase	64,85	ethanol	alcohol dehydrogenase	MESH:D000431	78959(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY gluten-based|dobj|metabolism gluten-based|advcl|altering altering|dobj|status status|amod|END_ENTITY	Wheat gluten-based diet retarded ethanol metabolism by altering alcohol_dehydrogenase and not carnitine status in adult rats .
853309	0	ethanol	81,88	alcohol_dehydrogenase	25,46	ethanol	alcohol dehydrogenase	MESH:D000431	10327	Chemical	Gene	oxido-reduction|nmod|START_ENTITY END_ENTITY|nmod|oxido-reduction	Assay of brain and liver alcohol_dehydrogenase by the coupled oxido-reduction of ethanol and lactaldehyde in the presence of deoxycholate .
9063813	0	ethanol	37,44	alcohol_dehydrogenase	8,29	ethanol	alcohol dehydrogenase	MESH:D000431	78959(Tax:10116)	Chemical	Gene	elimination|compound|START_ENTITY END_ENTITY|nmod|elimination	Role of alcohol_dehydrogenase in rat ethanol elimination kinetics .
926459	0	ethanol	31,38	alcohol_dehydrogenase	86,107	ethanol	alcohol dehydrogenase	MESH:D000431	78959(Tax:10116)	Chemical	Gene	elimination|compound|START_ENTITY Effect|nmod|elimination Effect|nmod|END_ENTITY	Effect of methylmercury on the ethanol elimination from the blood and the activity of alcohol_dehydrogenase .
958323	0	ethanol	8,15	alcohol_dehydrogenase	48,69	ethanol	alcohol dehydrogenase	MESH:D000431	10327	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|dep|roles roles|nmod|END_ENTITY	Hepatic ethanol metabolism : respective roles of alcohol_dehydrogenase , the microsomal ethanol-oxidizing system , and catulase .
992568	0	ethanol	137,144	alcohol_dehydrogenase	87,108	ethanol	alcohol dehydrogenase	MESH:D000431	78959(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY increase|nmod|metabolism END_ENTITY|nmod|increase	Ethanol metabolism in perfused rat liver at low ethanol concentrations : involvement of alcohol_dehydrogenase in the adaptive increase in ethanol metabolism due to chronic pretreatment with ethanol .
992568	0	ethanol	189,196	alcohol_dehydrogenase	87,108	ethanol	alcohol dehydrogenase	MESH:D000431	78959(Tax:10116)	Chemical	Gene	pretreatment|nmod|START_ENTITY due|nmod|pretreatment metabolism|amod|due increase|nmod|metabolism END_ENTITY|nmod|increase	Ethanol metabolism in perfused rat liver at low ethanol concentrations : involvement of alcohol_dehydrogenase in the adaptive increase in ethanol metabolism due to chronic pretreatment with ethanol .
992568	0	ethanol	48,55	alcohol_dehydrogenase	87,108	ethanol	alcohol dehydrogenase	MESH:D000431	78959(Tax:10116)	Chemical	Gene	concentrations|compound|START_ENTITY liver|nmod|concentrations metabolism|nmod|liver metabolism|dep|involvement involvement|nmod|END_ENTITY	Ethanol metabolism in perfused rat liver at low ethanol concentrations : involvement of alcohol_dehydrogenase in the adaptive increase in ethanol metabolism due to chronic pretreatment with ethanol .
7002807	0	ethanol	75,82	aldehyde_dehydrogenase	26,48	ethanol	aldehyde dehydrogenase	MESH:D000431	25375(Tax:10116)	Chemical	Gene	modulation|nmod|START_ENTITY END_ENTITY|dep|modulation	Testicular and epididymal aldehyde_dehydrogenase in rodents : modulation by ethanol and disulfiram .
3149773	0	ethanol	120,127	angiotensin_II	51,65	ethanol	angiotensin II	MESH:D000431	24179(Tax:10116)	Chemical	Gene	treated|nmod|START_ENTITY role|acl|treated role|nmod|END_ENTITY	The role of dopamine in the facilitatory effect of angiotensin_II on impaired learning in rats chronically treated with ethanol .
8117752	0	ethanol	10,17	apolipoprotein_B	29,45	ethanol	apolipoprotein B	MESH:D000431	338	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|synthesis synthesis|amod|END_ENTITY	Effect of ethanol on hepatic apolipoprotein_B synthesis and secretion in vitro .
3600293	0	ethanol	44,51	arginine-vasopressin	70,90	ethanol	arginine-vasopressin	MESH:D000431	551	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|release release|nmod|END_ENTITY	Naloxone decreases the inhibiting effect of ethanol on the release of arginine-vasopressin induced by cigarette smoking in man .
4085411	0	ethanol	10,17	arginine-vasopressin_and_oxytocin	53,86	ethanol	arginine-vasopressin and oxytocin	MESH:D000431	24221(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of ethanol and acetaldehyde on the release of arginine-vasopressin_and_oxytocin from the isolated hypothalamo-hypophyseal system of rats .
22440693	0	ethanol	21,28	aspartyl_aminopeptidase	58,81	ethanol	aspartyl aminopeptidase	MESH:D000431	13437(Tax:10090)	Chemical	Gene	intake|compound|START_ENTITY intake|nmod|END_ENTITY	Influence of chronic ethanol intake on mouse synaptosomal aspartyl_aminopeptidase and aminopeptidase_A : relationship with oxidative stress indicators .
1449564	0	ethanol	40,47	atrial_natriuretic_factor	7,32	ethanol	atrial natriuretic factor	MESH:D000431	4878	Chemical	Gene	ingestion|compound|START_ENTITY END_ENTITY|nmod|ingestion	Plasma atrial_natriuretic_factor during ethanol ingestion in volume-loaded subjects .
26073313	0	ethanol	182,189	b-glucosidase	154,167	ethanol	b-glucosidase	MESH:D000431	851007(Tax:4932)	Chemical	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	Heterologously expressed Aspergillus aculeatus b-glucosidase in Saccharomyces_cerevisiae is a cost-effective alternative to commercial supplementation of b-glucosidase in industrial ethanol production using Trichoderma_reesei cellulases .
26073313	0	ethanol	182,189	b-glucosidase	47,60	ethanol	b-glucosidase	MESH:D000431	851007(Tax:4932)	Chemical	Gene	production|compound|START_ENTITY b-glucosidase|nmod|production supplementation|nmod|b-glucosidase alternative|nmod|supplementation alternative|nsubj|END_ENTITY	Heterologously expressed Aspergillus aculeatus b-glucosidase in Saccharomyces_cerevisiae is a cost-effective alternative to commercial supplementation of b-glucosidase in industrial ethanol production using Trichoderma_reesei cellulases .
10443994	0	ethanol	9,16	bcl-2	33,38	ethanol	bcl-2	MESH:D000431	24224(Tax:10116)	Chemical	Gene	exposure|compound|START_ENTITY alters|nsubj|exposure alters|dobj|levels levels|amod|END_ENTITY	Neonatal ethanol exposure alters bcl-2 family mRNA levels in the rat cerebellar vermis .
11489446	0	ethanol	32,39	bcl-2	61,66	ethanol	bcl-2	MESH:D000431	24224(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of prenatal exposure to ethanol on the expression of bcl-2 , bax and caspase_3 in the developing rat cerebral cortex and thalamus .
25623404	0	ethanol	117,124	bcl-2	67,72	ethanol	bcl-2	MESH:D000431	24224(Tax:10116)	Chemical	Gene	proteins|nmod|START_ENTITY proteins|amod|END_ENTITY	Apoptotic cell death and temporal expression of apoptotic proteins bcl-2 and bax in the hippocampus , following binge ethanol in the neonatal rat model .
10029202	0	ethanol	11,18	beta-endorphin	78,92	ethanol	beta-endorphin	MESH:D000431	5443	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|release release|amod|END_ENTITY	Effects of ethanol on alpha-adrenergic and beta-adrenergic agonist-stimulated beta-endorphin release and cAMP production in hypothalamic cells in primary cultures .
12198391	0	ethanol	90,97	beta-endorphin	46,60	ethanol	beta-endorphin	MESH:D000431	5443	Chemical	Gene	Differences|nmod|START_ENTITY Differences|nmod|responses responses|nmod|END_ENTITY	Differences in the responses of the pituitary beta-endorphin and cardiovascular system to ethanol and stress as a function of family history .
15388297	0	ethanol	31,38	beta-endorphin	63,77	ethanol	beta-endorphin	MESH:D000431	18976(Tax:10090)	Chemical	Gene	self-administration|nmod|START_ENTITY self-administration|acl|lacking lacking|dobj|END_ENTITY	Operant self-administration of ethanol in C57BL/6 mice lacking beta-endorphin and enkephalin .
1578384	0	ethanol	113,120	beta-endorphin	88,102	ethanol	beta-endorphin	MESH:D000431	18976(Tax:10090)	Chemical	Gene	present|nmod|START_ENTITY present|dobj|sensitivity sensitivity|nmod|system system|amod|END_ENTITY	The alcohol-preferring C57BL/6 mice present an enhanced sensitivity of the hypothalamic beta-endorphin system to ethanol than the alcohol-avoiding DBA/2 mice .
15834231	0	ethanol	215,222	beta-endorphin	75,89	ethanol	beta-endorphin	MESH:D000431	5443	Chemical	Gene	treatment|compound|START_ENTITY effects|nmod|treatment release|dep|effects release|amod|END_ENTITY	Vasoactive intestinal peptide and corticotropin-releasing_hormone increase beta-endorphin release and proopiomelanocortin messenger RNA levels in primary cultures of hypothalamic cells : effects of acute and chronic ethanol treatment .
16934320	0	ethanol	34,41	beta-endorphin	45,59	ethanol	beta-endorphin	MESH:D000431	5443	Chemical	Gene	START_ENTITY|nmod|level level|amod|END_ENTITY	Effect of acute administration of ethanol on beta-endorphin plasma level in ethanol preferring and non-preferring rats chronically treated with naltrexone .
16934320	0	ethanol	76,83	beta-endorphin	45,59	ethanol	beta-endorphin	MESH:D000431	5443	Chemical	Gene	level|nmod|START_ENTITY level|amod|END_ENTITY	Effect of acute administration of ethanol on beta-endorphin plasma level in ethanol preferring and non-preferring rats chronically treated with naltrexone .
20586752	0	ethanol	69,76	beta-endorphin	33,47	ethanol	beta-endorphin	MESH:D000431	18976(Tax:10090)	Chemical	Gene	abolishes|nmod|START_ENTITY abolishes|dobj|response response|amod|END_ENTITY	Period_2 gene deletion abolishes beta-endorphin neuronal response to ethanol .
2137624	0	ethanol	109,116	beta-endorphin	32,46	ethanol	beta-endorphin	MESH:D000431	18976(Tax:10090)	Chemical	Gene	solutions|compound|START_ENTITY mice|nmod|solutions strains|nmod|mice system|nmod|strains system|compound|END_ENTITY	Effects of ethanol on the brain beta-endorphin system in inbred strains of mice with variable preference for ethanol solutions : in vitro study .
2137624	0	ethanol	11,18	beta-endorphin	32,46	ethanol	beta-endorphin	MESH:D000431	18976(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|system system|compound|END_ENTITY	Effects of ethanol on the brain beta-endorphin system in inbred strains of mice with variable preference for ethanol solutions : in vitro study .
23770261	0	ethanol	57,64	beta-endorphin	23,37	ethanol	beta-endorphin	MESH:D000431	18976(Tax:10090)	Chemical	Gene	reward|compound|START_ENTITY role|nmod|reward role|nmod|END_ENTITY	The role of endogenous beta-endorphin and enkephalins in ethanol reward .
2943358	0	ethanol	13,20	beta-endorphin	61,75	ethanol	beta-endorphin	MESH:D000431	18976(Tax:10090)	Chemical	Gene	dependence|compound|START_ENTITY Influence|nmod|dependence Influence|nmod|content content|nmod|END_ENTITY	Influence of ethanol dependence on regional brain content of beta-endorphin in the mouse .
2948086	0	ethanol	52,59	beta-endorphin	113,127	ethanol	beta-endorphin	MESH:D000431	18976(Tax:10090)	Chemical	Gene	differences|compound|START_ENTITY strains|nmod|differences strains|nmod|content content|nmod|END_ENTITY	Inbred strains of mice with variable sensitivity to ethanol exhibit differences in the content and processing of beta-endorphin .
7625566	0	ethanol	10,17	beta-endorphin	214,228	ethanol	beta-endorphin	MESH:D000431	5443	Chemical	Gene	enzyme|dep|START_ENTITY blockers|amod|enzyme Effect|nmod|blockers Effect|dep|evidence evidence|nmod|role role|nmod|acetaldehyde acetaldehyde|nmod|stimulation stimulation|nmod|release release|amod|END_ENTITY	Effect of ethanol , propanol , butanol , and catalase enzyme blockers on beta-endorphin secretion from primary cultures of hypothalamic neurons : evidence for a mediatory role of acetaldehyde in ethanol stimulation of beta-endorphin release .
7625566	0	ethanol	10,17	beta-endorphin	70,84	ethanol	beta-endorphin	MESH:D000431	5443	Chemical	Gene	enzyme|dep|START_ENTITY blockers|amod|enzyme blockers|nmod|secretion secretion|amod|END_ENTITY	Effect of ethanol , propanol , butanol , and catalase enzyme blockers on beta-endorphin secretion from primary cultures of hypothalamic neurons : evidence for a mediatory role of acetaldehyde in ethanol stimulation of beta-endorphin release .
7625566	0	ethanol	191,198	beta-endorphin	214,228	ethanol	beta-endorphin	MESH:D000431	5443	Chemical	Gene	stimulation|compound|START_ENTITY stimulation|nmod|release release|amod|END_ENTITY	Effect of ethanol , propanol , butanol , and catalase enzyme blockers on beta-endorphin secretion from primary cultures of hypothalamic neurons : evidence for a mediatory role of acetaldehyde in ethanol stimulation of beta-endorphin release .
7625566	0	ethanol	191,198	beta-endorphin	70,84	ethanol	beta-endorphin	MESH:D000431	5443	Chemical	Gene	stimulation|compound|START_ENTITY acetaldehyde|nmod|stimulation role|nmod|acetaldehyde evidence|nmod|role Effect|dep|evidence Effect|nmod|blockers blockers|nmod|secretion secretion|amod|END_ENTITY	Effect of ethanol , propanol , butanol , and catalase enzyme blockers on beta-endorphin secretion from primary cultures of hypothalamic neurons : evidence for a mediatory role of acetaldehyde in ethanol stimulation of beta-endorphin release .
7925590	0	ethanol	68,75	beta-endorphin	31,45	ethanol	beta-endorphin	MESH:D000431	18976(Tax:10090)	Chemical	Gene	drinking|compound|START_ENTITY activity|nmod|drinking activity|nmod|system system|compound|END_ENTITY	Enhanced activity of the brain beta-endorphin system by free-choice ethanol drinking in C57BL/6 but not DBA/2 mice .
8611062	0	ethanol	52,59	beta-endorphin	34,48	ethanol	beta-endorphin	MESH:D000431	5443	Chemical	Gene	sensitivity|nmod|START_ENTITY sensitivity|nmod|END_ENTITY	Enhanced sensitivity of pituitary beta-endorphin to ethanol in subjects at high risk of alcoholism .
9309309	0	ethanol	11,18	beta-endorphin	70,84	ethanol	beta-endorphin	MESH:D000431	5443	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|increases increases|nmod|release release|amod|END_ENTITY	Effects of ethanol on basal and prostaglandin_E1-induced increases in beta-endorphin release and intracellular cAMP levels in hypothalamic cells .
23279128	0	ethanol	112,119	brain-derived_neurotrophic_factor	12,45	ethanol	brain-derived neurotrophic factor	MESH:D000431	12064(Tax:10090)	Chemical	Gene	motivation|compound|START_ENTITY mediating|dobj|motivation switches|dep|mediating switches|nsubj|Infusion Infusion|nmod|END_ENTITY	Infusion of brain-derived_neurotrophic_factor into the ventral tegmental area switches the substrates mediating ethanol motivation .
24650733	0	ethanol	102,109	brain-derived_neurotrophic_factor	38,71	ethanol	brain-derived neurotrophic factor	MESH:D000431	24225(Tax:10116)	Chemical	Gene	administration|nmod|START_ENTITY increases|nmod|administration increases|dobj|expression expression|nmod|END_ENTITY	Estradiol increases expression of the brain-derived_neurotrophic_factor after acute administration of ethanol in the neonatal rat cerebellum .
8552271	0	ethanol	8,15	brain-derived_neurotrophic_factor	41,74	ethanol	brain-derived neurotrophic factor	MESH:D000431	24225(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY decreases|nsubj|administration decreases|dobj|expression expression|amod|END_ENTITY	Chronic ethanol administration decreases brain-derived_neurotrophic_factor gene expression in the rat hippocampus .
10443981	0	ethanol	182,189	c-Fos	39,44	ethanol	c-Fos	MESH:D000431	14281(Tax:10090)	Chemical	Gene	action|compound|START_ENTITY mechanisms|nmod|action relationships|nmod|mechanisms expression|dep|relationships expression|nmod|END_ENTITY	Chlordiazepoxide-induced expression of c-Fos in the central extended amygdala and other brain regions of the C57BL/6J and DBA/2J inbred mouse strains : relationships to mechanisms of ethanol action .
10751579	0	ethanol	6,13	c-Fos	27,32	ethanol	c-Fos	MESH:D000431	314322(Tax:10116)	Chemical	Gene	induction|compound|START_ENTITY induction|nmod|immunoreactivity immunoreactivity|amod|END_ENTITY	Acute ethanol induction of c-Fos immunoreactivity in pre-pro-enkephalin expressing neurons of the central nucleus of the amygdala .
11371719	0	ethanol	56,63	c-Fos	14,19	ethanol	c-Fos	MESH:D000431	314322(Tax:10116)	Chemical	Gene	responding|nmod|START_ENTITY Expression|acl|responding Expression|nmod|END_ENTITY	Expression of c-Fos in Alko alcohol rats responding for ethanol in an operant paradigm .
12818716	0	ethanol	35,42	c-Fos	82,87	ethanol	c-Fos	MESH:D000431	314322(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|immunoreactivity immunoreactivity|amod|END_ENTITY	Effects of intracerebroventricular ethanol on ingestive behavior and induction of c-Fos immunoreactivity in selected brain regions .
14574439	0	ethanol	69,76	c-Fos	27,32	ethanol	c-Fos	MESH:D000431	314322(Tax:10116)	Chemical	Gene	re-exposure|nmod|START_ENTITY environment|amod|re-exposure expression|nmod|environment END_ENTITY|dobj|expression	Different pattern of brain c-Fos expression following re-exposure to ethanol or sucrose self-administration environment .
16274676	0	ethanol	68,75	c-Fos	14,19	ethanol	c-Fos	MESH:D000431	14281(Tax:10090)	Chemical	Gene	administration|compound|START_ENTITY nucleus|nmod|administration END_ENTITY|nmod|nucleus	Expression of c-Fos in the mouse Edinger-Westphal nucleus following ethanol administration is not secondary to hypothermia or stress .
18692030	0	ethanol	97,104	c-Fos	31,36	ethanol	c-Fos	MESH:D000431	314322(Tax:10116)	Chemical	Gene	training|compound|START_ENTITY alterations|nmod|training alterations|nmod|immunoreactivity immunoreactivity|amod|END_ENTITY	Ethanol-induced alterations of c-Fos immunoreactivity in specific limbic brain regions following ethanol discrimination training .
23745109	0	ethanol	133,140	c-Fos	0,5	ethanol	c-Fos	MESH:D000431	314322(Tax:10116)	Chemical	Gene	administration|nmod|START_ENTITY immunoreactivity|nmod|administration immunoreactivity|nsubj|END_ENTITY	c-Fos immunoreactivity in prefrontal , basal ganglia and limbic areas of the rat brain after central and peripheral administration of ethanol and its metabolite acetaldehyde .
8892522	0	ethanol	48,55	c-Fos	0,5	ethanol	c-Fos	MESH:D000431	314322(Tax:10116)	Chemical	Gene	aversions|amod|START_ENTITY brainstem|nmod|aversions brainstem|nsubj|induction induction|amod|END_ENTITY	c-Fos induction in rat brainstem in response to ethanol - and lithium_chloride-induced conditioned taste aversions .
9426840	0	ethanol	65,72	c-Fos	14,19	ethanol	c-Fos	MESH:D000431	314322(Tax:10116)	Chemical	Gene	withdrawal|compound|START_ENTITY brain|nmod|withdrawal immunoreactivity|nmod|brain immunoreactivity|amod|END_ENTITY	Expression of c-Fos protein immunoreactivity in rat brain during ethanol withdrawal is prevented by nifedipine .
12217933	0	ethanol	89,96	c-fos	27,32	ethanol	c-fos	MESH:D000431	314322(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY Effects|nmod|administration Effects|nmod|induction induction|amod|END_ENTITY	Effects of acetaldehyde on c-fos mRNA induction in the paraventricular nucleus following ethanol administration .
1328519	0	ethanol	102,109	c-fos	140,145	ethanol	c-fos	MESH:D000431	314322(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY Involvement|nmod|effect Involvement|nmod|expression expression|amod|END_ENTITY	Involvement of gamma-aminobutyric_acid and N-methyl-D-aspartate receptors in the inhibitory effect of ethanol on pentylenetetrazole-induced c-fos expression in rat brain .
16470400	0	ethanol	23,30	c-fos	71,76	ethanol	c-fos	MESH:D000431	314322(Tax:10116)	Chemical	Gene	withdrawal|compound|START_ENTITY experience|nmod|withdrawal increases|nsubj|experience increases|dobj|expression expression|amod|END_ENTITY	Previous experience of ethanol withdrawal increases withdrawal-induced c-fos expression in limbic areas , but not withdrawal-induced anxiety and prevents withdrawal-induced elevations in plasma corticosterone .
1845539	0	ethanol	24,31	c-fos	70,75	ethanol	c-fos	MESH:D000431	314322(Tax:10116)	Chemical	Gene	administration|nmod|START_ENTITY suppresses|nsubj|administration suppresses|dobj|expression expression|amod|END_ENTITY	Acute administration of ethanol suppresses pentylenetetrazole-induced c-fos expression in rat brain .
18685859	0	ethanol	27,34	c-fos	58,63	ethanol	c-fos	MESH:D000431	14281(Tax:10090)	Chemical	Gene	administration|compound|START_ENTITY Hyperthermia|nmod|administration induces|nsubj|Hyperthermia induces|dobj|expression expression|amod|END_ENTITY	Hyperthermia combined with ethanol administration induces c-fos expression in the central amygdaloid nucleus of the mouse brain .
20570698	0	ethanol	138,145	c-fos	38,43	ethanol	c-fos	MESH:D000431	314322(Tax:10116)	Chemical	Gene	levels|nmod|START_ENTITY exposed|nmod|levels exposed|nsubj|Patterns Patterns|nmod|END_ENTITY	Patterns of social-experience-related c-fos and Arc expression in the frontal cortices of rats exposed to saccharin or moderate levels of ethanol during prenatal brain development .
21153235	7	ethanol	1019,1026	c-fos	1056,1061	ethanol	c-fos	MESH:D000431	2353	Chemical	Gene	blocks|nsubj|START_ENTITY blocks|dobj|induction induction|nmod|expression expression|amod|END_ENTITY	Second , we tested whether ethanol blocks the cold induction of c-fos expression in TRH neurons of the PVN .
2127308	0	ethanol	24,31	c-fos	70,75	ethanol	c-fos	MESH:D000431	314322(Tax:10116)	Chemical	Gene	administration|nmod|START_ENTITY suppresses|nsubj|administration suppresses|dobj|expression expression|amod|END_ENTITY	Acute administration of ethanol suppresses pentylenetetrazole-induced c-fos expression in rat brain .
7968356	0	ethanol	27,34	c-fos	60,65	ethanol	c-fos	MESH:D000431	314322(Tax:10116)	Chemical	Gene	administration|nmod|START_ENTITY increases|nsubj|administration increases|dobj|mRNA mRNA|amod|END_ENTITY	A single administration of ethanol simultaneously increases c-fos mRNA and reduces c-jun mRNA in the hypothalamus and hippocampus .
8813616	0	ethanol	90,97	c-fos	29,34	ethanol	c-fos	MESH:D000431	14281(Tax:10090)	Chemical	Gene	tolerance|compound|START_ENTITY maintain|dobj|tolerance oligonucleotide|advcl|maintain oligonucleotide|nmod|blocks blocks|amod|END_ENTITY	Antisense oligonucleotide to c-fos blocks the ability of arginine_vasopressin to maintain ethanol tolerance .
8982717	0	ethanol	78,85	c-fos	42,47	ethanol	c-fos	MESH:D000431	314322(Tax:10116)	Chemical	Gene	withdrawal|compound|START_ENTITY undergoing|dobj|withdrawal rats|acl|undergoing reduces|nmod|rats reduces|dobj|expression expression|amod|END_ENTITY	The anti-craving drug acamprosate reduces c-fos expression in rats undergoing ethanol withdrawal .
9191080	0	ethanol	11,18	c-fos	53,58	ethanol	c-fos	MESH:D000431	2353	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|amod|END_ENTITY	Effects of ethanol on muscarinic receptor-stimulated c-fos expression in human neuroblastoma cells .
9666163	0	ethanol	6,13	c-fos	22,27	ethanol	c-fos	MESH:D000431	314322(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|immunoreactivity immunoreactivity|amod|END_ENTITY	Acute ethanol induces c-fos immunoreactivity in GABAergic neurons of the central nucleus of the amygdala .
22169498	0	ethanol	24,31	c-jun_N-terminal_kinase	35,58	ethanol	c-jun N-terminal kinase	MESH:D000431	116554(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Differential effects of ethanol on c-jun_N-terminal_kinase , 14-3-3 proteins , and Bax in postnatal day 4 and postnatal day 7 rat cerebellum .
23266705	0	ethanol	63,70	carbohydrate_response_element-binding_protein	14,59	ethanol	carbohydrate response element-binding protein	MESH:D000431	58805(Tax:10090)	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of carbohydrate_response_element-binding_protein by ethanol .
8122416	0	ethanol	15,22	carboxypeptidase_H	69,87	ethanol	carboxypeptidase H	MESH:D000431	25669(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	-LSB- The effect of ethanol on the activity of soluble and membrane-bound carboxypeptidase_H in areas of the rat brain during immobilization stress -RSB- .
8364612	0	ethanol	15,22	carboxypeptidase_H	26,44	ethanol	carboxypeptidase H	MESH:D000431	25669(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY -LSB-|dobj|effect -LSB-|nmod|activity activity|amod|END_ENTITY	-LSB- The effect of ethanol on carboxypeptidase_H activity in the hypophysis and some sections of the brain in rats under different stressful exposures -RSB- .
1407407	0	ethanol	50,57	catalase	90,98	ethanol	catalase	MESH:D000431	24248(Tax:10116)	Chemical	Gene	consumption|compound|START_ENTITY triazole|nmod|consumption effect|dep|triazole effect|dep|evidence evidence|nmod|involvement involvement|compound|END_ENTITY	The effect of 3-amino-1 ,2,4 - triazole on voluntary ethanol consumption : evidence for brain catalase involvement in the mechanism of action .
16102377	0	ethanol	78,85	catalase	6,14	ethanol	catalase	MESH:D000431	12359(Tax:10090)	Chemical	Gene	produced|nmod|START_ENTITY produced|nsubj|potentiation potentiation|compound|END_ENTITY	Brain catalase mediates potentiation of social recognition memory produced by ethanol in mice .
16109828	0	ethanol	118,125	catalase	26,34	ethanol	catalase	MESH:D000431	12359(Tax:10090)	Chemical	Gene	exposure|compound|START_ENTITY signaling|nmod|exposure antagonizes|xcomp|signaling antagonizes|nsubj|overexpression overexpression|nmod|END_ENTITY	Cardiac overexpression of catalase antagonizes ADH-associated contractile depression and stress signaling after acute ethanol exposure in murine myocytes .
17980789	0	ethanol	31,38	catalase	54,62	ethanol	catalase	MESH:D000431	24248(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY reinforcing|dobj|effects Central|acl|reinforcing blocked|nsubjpass|Central blocked|nmod|inhibition inhibition|amod|END_ENTITY	Central reinforcing effects of ethanol are blocked by catalase inhibition .
18587667	0	ethanol	39,46	catalase	93,101	ethanol	catalase	MESH:D000431	24248(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY Reduction|nmod|effects Reduction|dep|role role|nmod|inhibitors inhibitors|amod|END_ENTITY	Reduction in the anxiolytic effects of ethanol by centrally formed acetaldehyde : the role of catalase inhibitors and acetaldehyde-sequestering agents .
2058789	0	ethanol	68,75	catalase	25,33	ethanol	catalase	MESH:D000431	24248(Tax:10116)	Chemical	Gene	oxidation|compound|START_ENTITY evidence|nmod|oxidation Studies|dep|evidence Studies|nmod|interaction interaction|compound|END_ENTITY	Studies on ethanol-brain catalase interaction : evidence for central ethanol oxidation .
21032900	0	ethanol	50,57	catalase	12,20	ethanol	catalase	MESH:D000431	24248(Tax:10116)	Chemical	Gene	characteristics|compound|START_ENTITY Effects|nmod|characteristics Effects|nmod|activators activators|amod|END_ENTITY	-LSB- Effects of catalase activators and inhibitors on ethanol pharmacokinetic characteristics and ethanol and aldehyde-metabolizing enzyme activities in the rat liver and brain -RSB- .
21528208	0	ethanol	34,41	catalase	80,88	ethanol	catalase	MESH:D000431	12359(Tax:10090)	Chemical	Gene	catabolism|compound|START_ENTITY increase|dobj|catabolism increase|nmod|utilization utilization|nmod|pathway pathway|amod|END_ENTITY	Peroxisome proliferators increase ethanol catabolism through utilization of the catalase pathway .
2295642	0	ethanol	74,81	catalase	27,35	ethanol	catalase	MESH:D000431	24248(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY interactions|nmod|metabolism interactions|nmod|pathways pathways|amod|END_ENTITY	Redox interactions between catalase and alcohol_dehydrogenase pathways of ethanol metabolism in the perfused rat liver .
26074427	0	ethanol	36,43	catalase	10,18	ethanol	catalase	MESH:D000431	12359(Tax:10090)	Chemical	Gene	embryopathies|compound|START_ENTITY protects|nmod|embryopathies protects|nsubj|END_ENTITY	Embryonic catalase protects against ethanol embryopathies in acatalasemic mice and transgenic human catalase-expressing mice in embryo culture .
2646962	0	ethanol	115,122	catalase	93,101	ethanol	catalase	MESH:D000431	24248(Tax:10116)	Chemical	Gene	effects|nmod:poss|START_ENTITY mediation|nmod|effects mediation|compound|END_ENTITY	Effects of 3-amino-1 ,2,4 - triazole on ethanol-induced open-field activity : evidence for brain catalase mediation of ethanol 's effects .
3169364	0	ethanol	18,25	catalase	50,58	ethanol	catalase	MESH:D000431	24248(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY treatment|nmod|inhibition inhibition|compound|END_ENTITY	Effect of chronic ethanol treatment under partial catalase inhibition on the activity of enzymes related to peroxide metabolism in rat liver and heart .
3426685	0	ethanol	93,100	catalase	126,134	ethanol	catalase	MESH:D000431	847	Chemical	Gene	system|compound|START_ENTITY system|nmod|END_ENTITY	Ethanol metabolism in alcohol dehydrogenase deficient deermice is mediated by the microsomal ethanol oxidizing system , not by catalase .
4040372	0	ethanol	126,133	catalase	70,78	ethanol	catalase	MESH:D000431	24248(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY END_ENTITY|nmod|administration	Discrepancy between the different subcellular activities of rat liver catalase and superoxide dismutases in response to acute ethanol administration .
4720713	0	ethanol	65,72	catalase	53,61	ethanol	catalase	MESH:D000431	24248(Tax:10116)	Chemical	Gene	oxidation|compound|START_ENTITY characteristics|nmod|oxidation characteristics|nmod|reaction reaction|nmod|END_ENTITY	The characteristics of the `` peroxidatic '' reaction of catalase in ethanol oxidation .
7236214	0	ethanol	53,60	catalase	70,78	ethanol	catalase	MESH:D000431	847	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Isotope effect in peroxidation of deuterium-labelled ethanol by liver catalase .
7546330	0	ethanol	28,35	catalase	73,81	ethanol	catalase	MESH:D000431	24248(Tax:10116)	Chemical	Gene	water|compound|START_ENTITY aminotriazole|nmod|water Effects|nmod|aminotriazole END_ENTITY|nsubj|Effects	Effects of aminotriazole on ethanol , water , and food intake and on brain catalase in UChA and UChB rats .
8060524	0	ethanol	72,79	catalase	43,51	ethanol	catalase	MESH:D000431	12359(Tax:10090)	Chemical	Gene	consumption|compound|START_ENTITY mediation|nmod|consumption END_ENTITY|nmod|mediation	Effects of 3-amino-1 ,2,4 - triazole on brain catalase in the mediation of ethanol consumption in mice .
8250977	0	ethanol	101,108	catalase	12,20	ethanol	catalase	MESH:D000431	24248(Tax:10116)	Chemical	Gene	presence|nmod|START_ENTITY developing|nmod|presence Increase|advcl|developing Increase|nmod|activity activity|amod|END_ENTITY	Increase in catalase activity in developing rat brain cell reaggregation cultures in the presence of ethanol .
8489262	0	ethanol	45,52	catalase	14,22	ethanol	catalase	MESH:D000431	12359(Tax:10090)	Chemical	Gene	oxidation|compound|START_ENTITY pathway|nmod|oxidation pathway|nsubj|Evidence Evidence|acl:relcl|END_ENTITY	Evidence that catalase is a major pathway of ethanol oxidation in vivo : dose-response studies in deer mice using methanol as a selective substrate .
8737012	0	ethanol	81,88	catalase	16,24	ethanol	catalase	MESH:D000431	24248(Tax:10116)	Chemical	Gene	effects|compound|START_ENTITY targets|nmod|effects neurons|nmod|targets Distribution|dep|neurons Distribution|nmod|END_ENTITY	Distribution of catalase in rat brain : aminergic neurons as possible targets for ethanol effects .
8892520	0	ethanol	40,47	catalase	8,16	ethanol	catalase	MESH:D000431	24248(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY Role|nmod|metabolism Role|nmod|END_ENTITY	Role of catalase in rat gastric mucosal ethanol metabolism in vitro .
8835370	0	ethanol	19,26	catechol-O-methyltransferase	83,111	ethanol	catechol-O-methyltransferase	MESH:D000431	1312	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Opposite effect of ethanol on recombinant membrane-bound and soluble activities of catechol-O-methyltransferase .
18684228	0	ethanol	29,36	catechol-o-methyltransferase	60,88	ethanol	catechol-o-methyltransferase	MESH:D000431	12846(Tax:10090)	Chemical	Gene	self-administration|compound|START_ENTITY Increase|nmod|self-administration Increase|nmod|mice mice|amod|END_ENTITY	Increase in free choice oral ethanol self-administration in catechol-o-methyltransferase gene-disrupted male mice .
2087903	0	ethanol	13,20	cathepsin_A	69,80	ethanol	cathepsin A	MESH:D000431	296370(Tax:10116)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|activity activity|nmod|END_ENTITY	Influence of ethanol and acetaldehyde on the activity and release of cathepsin_A from liver lysosomes .
3287991	0	ethanol	38,45	cholecystokinin	49,64	ethanol	cholecystokinin	MESH:D000431	25298(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Dose-additive inhibition of intake of ethanol by cholecystokinin and bombesin .
8278989	0	ethanol	68,75	cholecystokinin	29,44	ethanol	cholecystokinin	MESH:D000431	885	Chemical	Gene	extraction|compound|START_ENTITY using|nmod|extraction END_ENTITY|dep|using	Improved radioimmunoassay of cholecystokinin -LRB- CCK -RRB- using OAL-656 by ethanol extraction of human plasma .
10414603	0	ethanol	19,26	corticotropin-releasing_factor	71,101	ethanol	corticotropin-releasing factor	MESH:D000431	81648(Tax:10116)	Chemical	Gene	exposure|compound|START_ENTITY Effects|nmod|exposure Effects|nmod|END_ENTITY	Effects of chronic ethanol exposure on neurophysiological responses to corticotropin-releasing_factor and neuropeptide_Y .
12223538	0	ethanol	60,67	corticotropin-releasing_factor	152,182	ethanol	corticotropin-releasing factor	MESH:D000431	81648(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY exacerbation|nsubj|effect exacerbation|nmod|history history|nmod|dependence dependence|nmod|activation activation|nmod|mechanisms mechanisms|amod|END_ENTITY	Additive effect of stress and drug cues on reinstatement of ethanol seeking : exacerbation by history of dependence and role of concurrent activation of corticotropin-releasing_factor and opioid mechanisms .
12394282	0	ethanol	10,17	corticotropin-releasing_factor	137,167	ethanol	corticotropin-releasing factor	MESH:D000431	81648(Tax:10116)	Chemical	Gene	self-administration|compound|START_ENTITY self-administration|dep|regulation regulation|nmod|END_ENTITY	Increased ethanol self-administration and anxiety-like behavior during acute ethanol withdrawal and protracted abstinence : regulation by corticotropin-releasing_factor .
12394282	0	ethanol	77,84	corticotropin-releasing_factor	137,167	ethanol	corticotropin-releasing factor	MESH:D000431	81648(Tax:10116)	Chemical	Gene	withdrawal|compound|START_ENTITY self-administration|nmod|withdrawal self-administration|dep|regulation regulation|nmod|END_ENTITY	Increased ethanol self-administration and anxiety-like behavior during acute ethanol withdrawal and protracted abstinence : regulation by corticotropin-releasing_factor .
12782246	0	ethanol	121,128	corticotropin-releasing_factor	14,44	ethanol	corticotropin-releasing factor	MESH:D000431	81648(Tax:10116)	Chemical	Gene	abstinence|compound|START_ENTITY stress|nmod|abstinence attenuates|xcomp|stress attenuates|nsubj|Antagonism Antagonism|nmod|END_ENTITY	Antagonism of corticotropin-releasing_factor attenuates the enhanced responsiveness to stress observed during protracted ethanol abstinence .
15914027	0	ethanol	10,17	corticotropin-releasing_factor	39,69	ethanol	corticotropin-releasing factor	MESH:D000431	12918(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|regulation regulation|nmod|expression expression|amod|END_ENTITY	Effect of ethanol on the regulation of corticotropin-releasing_factor -LRB- CRF -RRB- gene expression .
15939087	0	ethanol	127,134	corticotropin-releasing_factor	51,81	ethanol	corticotropin-releasing factor	MESH:D000431	1392	Chemical	Gene	exposed|nmod|START_ENTITY animals|acl|exposed normalize|nmod|animals normalize|dobj|levels levels|amod|END_ENTITY	Postnatal handling does not normalize hypothalamic corticotropin-releasing_factor mRNA levels in animals prenatally exposed to ethanol .
16934947	0	ethanol	9,16	corticotropin-releasing_factor	63,93	ethanol	corticotropin-releasing factor	MESH:D000431	1392	Chemical	Gene	alters|compound|START_ENTITY sensitivity|nsubj|alters sensitivity|nmod|effects effects|nmod|END_ENTITY	Prenatal ethanol exposure alters sensitivity to the effects of corticotropin-releasing_factor -LRB- CRF -RRB- on behavior in the elevated plus-maze .
21487655	0	ethanol	66,73	corticotropin-releasing_factor	86,116	ethanol	corticotropin-releasing factor	MESH:D000431	12918(Tax:10090)	Chemical	Gene	drinking|compound|START_ENTITY drinking|nmod|type type|compound|END_ENTITY	Ethanol concentration-dependent effects and the role of stress on ethanol drinking in corticotropin-releasing_factor type 1 and double type 1 and 2 receptor knockout mice .
22333290	0	ethanol	89,96	corticotropin-releasing_factor	8,38	ethanol	corticotropin-releasing factor	MESH:D000431	12918(Tax:10090)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of corticotropin-releasing_factor and corticosterone in behavioral sensitization to ethanol .
24139460	0	ethanol	101,108	corticotropin-releasing_factor	11,41	ethanol	corticotropin-releasing factor	MESH:D000431	81648(Tax:10116)	Chemical	Gene	withdrawal|compound|START_ENTITY involved|nmod|withdrawal involved|nsubjpass|END_ENTITY	Amygdaloid corticotropin-releasing_factor is involved in the anxiolytic effect of acupuncture during ethanol withdrawal in rats .
25797192	0	ethanol	13,20	corticotropin-releasing_factor	31,61	ethanol	corticotropin-releasing factor	MESH:D000431	12918(Tax:10090)	Chemical	Gene	Reduction|nmod|START_ENTITY intake|nsubj|Reduction intake|nmod|antagonist antagonist|amod|END_ENTITY	Reduction of ethanol intake by corticotropin-releasing_factor receptor-1 antagonist in `` heavy-drinking '' mice in a free-choice paradigm .
3501867	0	ethanol	8,15	corticotropin-releasing_factor	73,103	ethanol	corticotropin-releasing factor	MESH:D000431	81648(Tax:10116)	Chemical	Gene	exposure|compound|START_ENTITY potentiates|nsubj|exposure potentiates|dobj|effects effects|nmod|END_ENTITY	Chronic ethanol exposure potentiates the locomotor-activating effects of corticotropin-releasing_factor -LRB- CRF -RRB- in rats .
6323684	0	ethanol	10,17	corticotropin-releasing_factor	81,111	ethanol	corticotropin-releasing factor	MESH:D000431	81648(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|role role|nmod|END_ENTITY	Effect of ethanol on the hypothalamic-pituitary-adrenal_axis in the rat : role of corticotropin-releasing_factor -LRB- CRF -RRB- .
7832471	0	ethanol	72,79	corticotropin-releasing_factor	12,42	ethanol	corticotropin-releasing factor	MESH:D000431	1392	Chemical	Gene	withdrawal|compound|START_ENTITY effects|nmod|withdrawal role|nmod|effects role|nmod|END_ENTITY	The role of corticotropin-releasing_factor in the anxiogenic effects of ethanol withdrawal .
8467387	0	ethanol	139,146	corticotropin-releasing_factor	20,50	ethanol	corticotropin-releasing factor	MESH:D000431	81648(Tax:10116)	Chemical	Gene	withdrawal|compound|START_ENTITY effects|nmod|withdrawal reverses|dobj|effects reverses|nsubj|Microinjection Microinjection|nmod|antagonist antagonist|amod|END_ENTITY	Microinjection of a corticotropin-releasing_factor antagonist into the central nucleus of the amygdala reverses anxiogenic-like effects of ethanol withdrawal .
9125418	0	ethanol	139,146	corticotropin-releasing_factor	8,38	ethanol	corticotropin-releasing factor	MESH:D000431	12918(Tax:10090)	Chemical	Gene	sleep|compound|START_ENTITY involved|nmod|sleep involved|nsubjpass|END_ENTITY	Central corticotropin-releasing_factor and benzodiazepine receptor systems are involved in the social isolation stress-induced decrease in ethanol sleep in mice .
9768550	0	ethanol	95,102	corticotropin-releasing_factor	55,85	ethanol	corticotropin-releasing factor	MESH:D000431	81648(Tax:10116)	Chemical	Gene	drinking|amod|START_ENTITY Effects|nmod|drinking Effects|nmod|injections injections|nmod|END_ENTITY	Effects of third intracerebroventricular injections of corticotropin-releasing_factor -LRB- CRF -RRB- on ethanol drinking and food intake .
12397512	0	ethanol	51,58	corticotropin_releasing_factor	11,41	ethanol	corticotropin releasing factor	MESH:D000431	12918(Tax:10090)	Chemical	Gene	role|acl|START_ENTITY role|nmod|END_ENTITY	A role for corticotropin_releasing_factor -LRB- CRF -RRB- in ethanol consumption , sensitivity , and reward as revealed by CRF-deficient mice .
21429093	0	ethanol	10,17	cyclin_D2	43,52	ethanol	cyclin D2	MESH:D000431	12444(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Increased ethanol intake and preference in cyclin_D2 knockout mice .
10235299	0	ethanol	64,71	cyclooxygenase-2	13,29	ethanol	cyclooxygenase-2	MESH:D000431	29527(Tax:10116)	Chemical	Gene	brain|nmod|START_ENTITY END_ENTITY|nmod|brain	Induction of cyclooxygenase-2 in brain during acute and chronic ethanol treatment and ethanol withdrawal .
15546477	0	ethanol	21,28	cyclooxygenase-2	32,48	ethanol	cyclooxygenase-2	MESH:D000431	29527(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Inhibitory action of ethanol on cyclooxygenase-2 expression through suppression of the extracellular signal-related kinase-mediated pathway in rat alveolar macrophages .
16385238	0	ethanol	17,24	cyclooxygenase-2	69,85	ethanol	cyclooxygenase-2	MESH:D000431	29527(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY administration|nmod|expression expression|nmod|nitric_oxide nitric_oxide|amod|END_ENTITY	Effects of acute ethanol administration on LPS-induced expression of cyclooxygenase-2 and inducible nitric_oxide synthase in rat alveolar macrophages .
10222015	0	ethanol	38,45	cyclosporin_A	17,30	ethanol	cyclosporin A	MESH:D000431	1161	Chemical	Gene	START_ENTITY|nsubj|Determination Determination|nmod|END_ENTITY	Determination of cyclosporin_A in 20 % ethanol by a magnetic beads-based immunofluorescence assay .
6497392	0	ethanol	75,82	cytochrome_P-450	38,54	ethanol	cytochrome P-450	MESH:D000431	100328948(Tax:9986)	Chemical	Gene	oxidation|compound|START_ENTITY oxidation|amod|END_ENTITY	Immunochemical evidence for a role of cytochrome_P-450 in liver microsomal ethanol oxidation .
1438024	0	ethanol	117,124	cytochrome_P450	13,28	ethanol	cytochrome P450	MESH:D000431	25251(Tax:10116)	Chemical	Gene	hepatocytes|nmod|START_ENTITY hepatocytes|nsubj|Evidence Evidence|nmod|toxicity toxicity|amod|END_ENTITY	Evidence for cytochrome_P450 2E1-mediated toxicity of N-nitrosodimethylamine in cultured perivenous hepatocytes from ethanol treated rats .
8302826	0	ethanol	10,17	cytochrome_P450	21,36	ethanol	cytochrome P450	MESH:D000431	25251(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of ethanol on cytochrome_P450 in the rat brain .
9844795	0	ethanol	35,42	cytochrome_P450	56,71	ethanol	cytochrome P450	MESH:D000431	4051	Chemical	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	Alcohol-associated rhabdomyolysis : ethanol induction of cytochrome_P450 may potentiate myotoxicity .
11804663	0	ethanol	61,68	cytochrome_P4502E1	12,30	ethanol	cytochrome P4502E1	MESH:D000431	1571	Chemical	Gene	induction|nmod|START_ENTITY Dynamics|dep|induction Dynamics|nmod|activity activity|amod|END_ENTITY	Dynamics of cytochrome_P4502E1 activity in man : induction by ethanol and disappearance during withdrawal phase .
12948850	0	ethanol	121,128	cytochrome_P4502E1	87,105	ethanol	cytochrome P4502E1	MESH:D000431	1571	Chemical	Gene	modulation|nmod|START_ENTITY END_ENTITY|dep|modulation	Interferon_gamma enhances proteasome activity in recombinant Hep G2 cells that express cytochrome_P4502E1 : modulation by ethanol .
7992014	1	ethanol	82,89	cytochrome_P450IIE1_and_catalase	116,148	ethanol	cytochrome P450IIE1 and catalase	MESH:D000431	847	Chemical	Gene	Metabolism|nmod|START_ENTITY Metabolism|nmod|-RSB- -RSB-|amod|END_ENTITY	I. Metabolism of ethanol by alcohol_dehydrogenase , cytochrome_P450IIE1_and_catalase -RSB- .
10801323	0	ethanol	58,65	cytochrome_P450_2E1	35,54	ethanol	cytochrome P450 2E1	MESH:D000431	1571	Chemical	Gene	substrates|compound|START_ENTITY END_ENTITY|nmod|substrates	Conformational modulation of human cytochrome_P450_2E1 by ethanol and other substrates : a CO flash photolysis study .
11570691	0	ethanol	95,102	cytochrome_P450_2E1	14,33	ethanol	cytochrome P450 2E1	MESH:D000431	1571	Chemical	Gene	epithelial|nmod|START_ENTITY epithelial|nsubj|Expression Expression|nmod|END_ENTITY	Expression of cytochrome_P450_2E1 in normal human bronchial epithelial cells and activation by ethanol in culture .
17219453	0	ethanol	20,27	cytochrome_P450_2E1	50,69	ethanol	cytochrome P450 2E1	MESH:D000431	1571	Chemical	Gene	oxidation|compound|START_ENTITY mechanism|nmod|oxidation mediated|nsubj|mechanism mediated|nmod|END_ENTITY	A new mechanism for ethanol oxidation mediated by cytochrome_P450_2E1 : bulk polarity of the active site makes a difference .
20006703	0	ethanol	32,39	cytochrome_P450_2E1	52,71	ethanol	cytochrome P450 2E1	MESH:D000431	100727914	Chemical	Gene	exposure|compound|START_ENTITY exposure|nmod|END_ENTITY	Differential effects of chronic ethanol exposure on cytochrome_P450_2E1 and the hypothalamic-pituitary-adrenal_axis in the maternal-fetal unit of the guinea_pig .
24863043	0	ethanol	83,90	cytochrome_P450_2E1	19,38	ethanol	cytochrome P450 2E1	MESH:D000431	13106(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY boosts|dobj|effects boosts|nsubj|Induction Induction|nmod|END_ENTITY	Induction of brain cytochrome_P450_2E1 boosts the locomotor-stimulating effects of ethanol in mice .
7980652	0	ethanol	88,95	cytochrome_P450_2E1	20,39	ethanol	cytochrome P450 2E1	MESH:D000431	25086(Tax:10116)	Chemical	Gene	FGC-4|nmod|START_ENTITY FGC-4|nsubj|Characterization Characterization|nmod|induction induction|amod|END_ENTITY	Characterization of cytochrome_P450_2E1 induction in a rat hepatoma FGC-4 cell model by ethanol .
9368031	0	ethanol	22,29	cytochrome_P450_2E1	39,58	ethanol	cytochrome P450 2E1	MESH:D000431	1571	Chemical	Gene	kinetics|nmod|START_ENTITY kinetics|nmod|END_ENTITY	Oxidation kinetics of ethanol by human cytochrome_P450_2E1 .
23519123	0	ethanol	48,55	cytochrome_P450_2e1	14,33	ethanol	cytochrome P450 2e1	MESH:D000431	1571	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of cytochrome_P450_2e1 expression by ethanol : role of oxidative stress-mediated pkc/jnk/sp1 pathway .
3115071	0	ethanol	16,23	diamine_oxidase	42,57	ethanol	diamine oxidase	MESH:D000431	65029(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY administration|nmod|activity activity|amod|END_ENTITY	Effect of acute ethanol administration on diamine_oxidase activity in maternal , embryonal and fetal tissues .
6428252	0	ethanol	16,23	diamine_oxidase	42,57	ethanol	diamine oxidase	MESH:D000431	65029(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY administration|nmod|activity activity|amod|END_ENTITY	Effect of acute ethanol administration on diamine_oxidase activity in the upper gastrointestinal tract of rat .
6433991	0	ethanol	70,77	diamine_oxidase	33,48	ethanol	diamine oxidase	MESH:D000431	65029(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY END_ENTITY|nmod|administration	Stimulation of hepatic and renal diamine_oxidase activity after acute ethanol administration .
11033008	0	ethanol	15,22	dopamine_D3_receptor	33,53	ethanol	dopamine D3 receptor	MESH:D000431	13490(Tax:10090)	Chemical	Gene	reward|compound|START_ENTITY Enhancement|nmod|reward Enhancement|nmod|blockade blockade|amod|END_ENTITY	Enhancement of ethanol reward by dopamine_D3_receptor blockade .
15894078	0	ethanol	69,76	dopamine_D3_receptor	14,34	ethanol	dopamine D3 receptor	MESH:D000431	29238(Tax:10116)	Chemical	Gene	consumption|compound|START_ENTITY attenuates|dobj|consumption attenuates|nsubj|SB-277011-A SB-277011-A|amod|END_ENTITY	The selective dopamine_D3_receptor antagonist SB-277011-A attenuates ethanol consumption in ethanol preferring -LRB- P -RRB- and non-preferring -LRB- NP -RRB- rats .
15894078	0	ethanol	92,99	dopamine_D3_receptor	14,34	ethanol	dopamine D3 receptor	MESH:D000431	29238(Tax:10116)	Chemical	Gene	attenuates|advcl|START_ENTITY attenuates|nsubj|SB-277011-A SB-277011-A|amod|END_ENTITY	The selective dopamine_D3_receptor antagonist SB-277011-A attenuates ethanol consumption in ethanol preferring -LRB- P -RRB- and non-preferring -LRB- NP -RRB- rats .
16452669	0	ethanol	69,76	dopamine_D3_receptor	4,24	ethanol	dopamine D3 receptor	MESH:D000431	13490(Tax:10090)	Chemical	Gene	consumption|compound|START_ENTITY regulating|dobj|consumption pathway|acl|regulating part|nmod|pathway part|nsubj|END_ENTITY	The dopamine_D3_receptor is part of a homeostatic pathway regulating ethanol consumption .
19662386	0	ethanol	111,118	dopamine_D3_receptor	26,46	ethanol	dopamine D3 receptor	MESH:D000431	13490(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A functional role for the dopamine_D3_receptor in the induction and expression of behavioural sensitization to ethanol in mice .
12842874	0	ethanol	49,56	dopamine_beta-hydroxylase	71,96	ethanol	dopamine beta-hydroxylase	MESH:D000431	1621	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Pharmacogenomic analysis of mechanisms mediating ethanol regulation of dopamine_beta-hydroxylase .
11165777	0	ethanol	35,42	dopamine_transporter	68,88	ethanol	dopamine transporter	MESH:D000431	6531	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Individual and combined effects of ethanol and cocaine on the human dopamine_transporter in neuronal cell lines .
15897718	0	ethanol	6,13	dopamine_transporter	24,44	ethanol	dopamine transporter	MESH:D000431	24898(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|velocity velocity|compound|END_ENTITY	Acute ethanol decreases dopamine_transporter velocity in rat striatum : in vivo and in vitro electrochemical measurements .
16786536	0	ethanol	45,52	dopamine_transporter	15,35	ethanol	dopamine transporter	MESH:D000431	13162(Tax:10090)	Chemical	Gene	effects|compound|START_ENTITY END_ENTITY|nmod|effects	No role of the dopamine_transporter in acute ethanol effects on striatal dopamine dynamics .
24510599	0	ethanol	20,27	dopamine_transporter	159,179	ethanol	dopamine transporter	MESH:D000431	13162(Tax:10090)	Chemical	Gene	exposure|nmod|START_ENTITY produces|nsubj|exposure produces|nmod|dysregulation dysregulation|nmod|expression expression|compound|END_ENTITY	Chronic exposure to ethanol of male mice before mating produces attention_deficit_hyperactivity_disorder-like phenotype along with epigenetic dysregulation of dopamine_transporter expression in mouse offspring .
21797886	0	ethanol	33,40	dynamin	11,18	ethanol	dynamin	MESH:D000431	45928(Tax:7227)	Chemical	Gene	tolerance|compound|START_ENTITY END_ENTITY|nmod|tolerance	A role for dynamin in triggering ethanol tolerance .
1590388	0	ethanol	24,31	endothelin-1	93,105	ethanol	endothelin-1	MESH:D000431	24323(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|role role|nmod|END_ENTITY	Effect of intravascular ethanol on modulation of gastric mucosal integrity : possible role of endothelin-1 .
17466482	0	ethanol	18,25	endothelin-1	41,53	ethanol	endothelin-1	MESH:D000431	24323(Tax:10116)	Chemical	Gene	consumption|compound|START_ENTITY consumption|nmod|generation generation|amod|END_ENTITY	Effect of chronic ethanol consumption on endothelin-1 generation and conversion of exogenous big-endothelin-1 by the rat carotid artery .
18469849	0	ethanol	8,15	endothelin-1	52,64	ethanol	endothelin-1	MESH:D000431	24323(Tax:10116)	Chemical	Gene	intake|compound|START_ENTITY modulates|nsubj|intake modulates|dobj|levels levels|nmod|receptor receptor|amod|END_ENTITY	Chronic ethanol intake modulates vascular levels of endothelin-1 receptor and enhances the pressor response to endothelin-1 in anaesthetized rats .
1884967	0	ethanol	10,17	endothelin-1	21,33	ethanol	endothelin-1	MESH:D000431	100009270(Tax:9986)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|release release|amod|END_ENTITY	Effect of ethanol on endothelin-1 release from gastric vasculature .
7590677	0	ethanol	8,15	endothelin-1	81,93	ethanol	endothelin-1	MESH:D000431	24323(Tax:10116)	Chemical	Gene	consumption|compound|START_ENTITY increases|nsubj|consumption increases|dobj|response response|nmod|END_ENTITY	Chronic ethanol consumption increases hepatic sinusoidal contractile response to endothelin-1 in the rat .
11163124	0	ethanol	9,16	enkephalin	72,82	ethanol	enkephalin	MESH:D000431	29237(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY induces|nsubj|administration induces|dobj|changes changes|nmod|concentrations concentrations|compound|END_ENTITY	Repeated ethanol administration induces short - and long-term changes in enkephalin and dynorphin tissue concentrations in rat brain .
20184566	0	ethanol	18,25	enkephalin	29,39	ethanol	enkephalin	MESH:D000431	29237(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of chronic ethanol on enkephalin in the hypothalamus and extra-hypothalamic areas .
22703995	0	ethanol	92,99	enkephalin	38,48	ethanol	enkephalin	MESH:D000431	29237(Tax:10116)	Chemical	Gene	anticipation|nmod|START_ENTITY expression|nmod|anticipation expression|compound|END_ENTITY	Disturbances in behavior and cortical enkephalin gene expression during the anticipation of ethanol in rats characterized as high_drinkers .
1759966	0	ethanol	10,17	epidermal_growth_factor_receptor	21,53	ethanol	epidermal growth factor receptor	MESH:D000431	24329(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of ethanol on epidermal_growth_factor_receptor in buccal mucosa .
19127349	0	ethanol	91,98	epidermal_growth_factor_receptor	121,153	ethanol	epidermal growth factor receptor	MESH:D000431	1956	Chemical	Gene	protection|nmod|START_ENTITY activation|nmod|protection involves|nsubj|activation involves|dobj|transactivation transactivation|compound|END_ENTITY	Leptin-induced cytosolic phospholipase A2 activation in gastric mucosal protection against ethanol cytotoxicity involves epidermal_growth_factor_receptor transactivation .
19617645	0	ethanol	167,174	epidermal_growth_factor_receptor	8,40	ethanol	epidermal growth factor receptor	MESH:D000431	1956	Chemical	Gene	cytotoxicity|compound|START_ENTITY cells|nmod|cytotoxicity protection|nmod|cells Role|nmod|protection Role|nmod|transactivation transactivation|compound|END_ENTITY	Role of epidermal_growth_factor_receptor transactivation in the activation of cytosolic_phospholipase_A -LRB- 2 -RRB- in leptin protection of salivary gland acinar cells against ethanol cytotoxicity .
8142061	0	ethanol	16,23	epidermal_growth_factor_receptor	37,69	ethanol	epidermal growth factor receptor	MESH:D000431	24329(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY treatment|nmod|END_ENTITY	Effect of acute ethanol treatment on epidermal_growth_factor_receptor in the rat stomach .
8888942	0	ethanol	8,15	epidermal_growth_factor_receptor	65,97	ethanol	epidermal growth factor receptor	MESH:D000431	24329(Tax:10116)	Chemical	Gene	feeding|compound|START_ENTITY alters|nsubj|feeding alters|dobj|structure structure|nmod|END_ENTITY	Chronic ethanol feeding alters the structure and function of the epidermal_growth_factor_receptor in rat stomach .
9067479	0	ethanol	80,87	epidermal_growth_factor_receptor	29,61	ethanol	epidermal growth factor receptor	MESH:D000431	24329(Tax:10116)	Chemical	Gene	feeding|compound|START_ENTITY alteration|nmod|feeding alteration|nmod|END_ENTITY	Time-dependent alteration of epidermal_growth_factor_receptor in rat stomach by ethanol feeding .
20004335	0	ethanol	20,27	galanin	47,54	ethanol	galanin	MESH:D000431	14419(Tax:10090)	Chemical	Gene	fat|compound|START_ENTITY intake|nmod|fat intake|nmod|mice mice|amod|END_ENTITY	Increased intake of ethanol and dietary fat in galanin overexpressing mice .
2864406	0	ethanol	15,22	gamma-glutamyltranspeptidase	53,81	ethanol	gamma-glutamyltranspeptidase	MESH:D000431	116568(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activities activities|compound|END_ENTITY	The effects of ethanol and diet on hepatic and serum gamma-glutamyltranspeptidase activities in rats .
10069571	0	ethanol	8,15	ganglioside_sialidase	26,47	ethanol	ganglioside sialidase	MESH:D000431	117185(Tax:10116)	Chemical	Gene	increases|compound|START_ENTITY END_ENTITY|nsubj|increases	Chronic ethanol increases ganglioside_sialidase activity in rat leukocytes , erythrocytes , and brain synaptosomes .
7910473	0	ethanol	134,141	gastric_alcohol_dehydrogenase	14,43	ethanol	gastric alcohol dehydrogenase	MESH:D000431	131	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY influence|nmod|pharmacokinetics has|dobj|influence has|nsubj|Inhibition Inhibition|nmod|activity activity|amod|END_ENTITY	Inhibition of gastric_alcohol_dehydrogenase activity by histamine H2-receptor antagonists has no influence on the pharmacokinetics of ethanol after a moderate dose .
9693201	0	ethanol	108,115	gastric_alcohol_dehydrogenase	40,69	ethanol	gastric alcohol dehydrogenase	MESH:D000431	131	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Helicobacter_pylori infection decreases gastric_alcohol_dehydrogenase activity and first-pass metabolism of ethanol in man .
11521741	0	ethanol	41,48	gastric_lipase	11,25	ethanol	gastric lipase	MESH:D000431	50682(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY activity|nmod|administration activity|amod|END_ENTITY	Changes of gastric_lipase activity after ethanol and indomethacin administration : influence of pretreatment with allopurinol , pentoxifylline and L-DOPA .
1186495	0	ethanol	44,51	gastrin	135,142	ethanol	gastrin	MESH:D000431	2520	Chemical	Gene	secretion|nmod|START_ENTITY secretion|parataxis|mediated mediated|nmod|END_ENTITY	Stimulation of thyrocalcitonin secretion by ethanol in patients with medullary_thyroid_carcinoma -- an effect apparently not mediated by gastrin .
2767348	0	ethanol	29,36	gastrin	85,92	ethanol	gastrin	MESH:D000431	25320(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY Effects|nmod|administration Effects|nmod|END_ENTITY	Effects of acute and chronic ethanol administration on the gastrointestinal hormones gastrin , enteroglucagon , pancreatic glucagon and peptide_YY in the rat .
2883103	0	ethanol	11,18	gastrin	35,42	ethanol	gastrin	MESH:D000431	25320(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|release release|compound|END_ENTITY	Effects of ethanol and nicotine on gastrin and somatostatin release in rats .
3678743	0	ethanol	10,17	gastrin	88,95	ethanol	gastrin	MESH:D000431	2520	Chemical	Gene	Action|nmod|START_ENTITY Action|nmod|END_ENTITY	Action of ethanol and some alcoholic beverages on gastric_acid secretion and release of gastrin in humans .
3770365	0	ethanol	36,43	gastrin	62,69	ethanol	gastrin	MESH:D000431	2520	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|concentration concentration|compound|END_ENTITY	Effect of intragastric infusions of ethanol and wine on serum gastrin concentration and gastric_acid secretion .
12107033	0	ethanol	15,22	glucose_6-phosphate_dehydrogenase	26,59	ethanol	glucose 6-phosphate dehydrogenase	MESH:D000431	2539	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activity activity|amod|END_ENTITY	The effects of ethanol on glucose_6-phosphate_dehydrogenase enzyme activity from human erythrocytes in vitro and rat erythrocytes in vivo .
12107033	1	ethanol	160,167	glucose_6-phosphate_dehydrogenase	183,216	ethanol	glucose 6-phosphate dehydrogenase	MESH:D000431	2539	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	AIMS : The effects of ethanol on erythrocyte glucose_6-phosphate_dehydrogenase -LRB- G6PD -RRB- activity were investigated under in vitro and in vivo conditions .
11095585	0	ethanol	20,27	glutathione_S-transferase	75,100	ethanol	glutathione S-transferase	MESH:D000431	58962(Tax:10116)	Chemical	Gene	exposure|compound|START_ENTITY Effect|nmod|exposure Effect|nmod|END_ENTITY	Effect of long-term ethanol exposure on the acinar distribution of hepatic glutathione_S-transferase .
12198402	0	ethanol	104,111	glutathione_S-transferase	49,74	ethanol	glutathione S-transferase	MESH:D000431	58962(Tax:10116)	Chemical	Gene	consumption|compound|START_ENTITY compromised|nmod|consumption compromised|nsubjpass|detoxification detoxification|nmod|END_ENTITY	4-hydroxynonenal detoxification by mitochondrial glutathione_S-transferase is compromised by short-term ethanol consumption in rats .
20650114	0	ethanol	10,17	glutathione_S-transferase	21,46	ethanol	glutathione S-transferase	MESH:D000431	58962(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of ethanol on glutathione_S-transferase expression in co-cultured rat hepatocytes .
12711929	0	ethanol	68,75	granzyme_B	23,33	ethanol	granzyme B	MESH:D000431	171528(Tax:10116)	Chemical	Gene	Reduction|nmod|START_ENTITY Reduction|nmod|END_ENTITY	Reduction of perforin , granzyme_B , and cytokine interferon_gamma by ethanol in male Fischer 344 rats .
11842056	0	ethanol	6,13	growth_factor	35,48	ethanol	growth factor	MESH:D000431	79215(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Acute ethanol increases angiogenic growth_factor gene expression in rat skeletal muscle .
1330488	0	ethanol	22,29	growth_hormone	42,56	ethanol	growth hormone	MESH:D000431	2688	Chemical	Gene	exposure|compound|START_ENTITY effect|nmod|exposure effect|nmod|expression expression|amod|END_ENTITY	The effect of `` binge '' ethanol exposure on growth_hormone and prolactin gene expression and secretion .
17207107	0	ethanol	61,68	growth_hormone	20,34	ethanol	growth hormone	MESH:D000431	2688	Chemical	Gene	attenuated|nmod|START_ENTITY attenuated|nsubjpass|response response|compound|END_ENTITY	Apomorphine-induced growth_hormone response is attenuated by ethanol but not dextromethorphan .
2646974	0	ethanol	61,68	growth_hormone	96,110	ethanol	growth hormone	MESH:D000431	81668(Tax:10116)	Chemical	Gene	levels|nmod|START_ENTITY levels|dep|relationship relationship|acl|pulsatile pulsatile|dobj|release release|amod|END_ENTITY	Diminished insulin-like growth factor-1 levels after chronic ethanol : relationship to pulsatile growth_hormone release .
3244403	0	ethanol	13,20	growth_hormone	24,38	ethanol	growth hormone	MESH:D000431	81668(Tax:10116)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|secretion secretion|amod|END_ENTITY	Influence of ethanol on growth_hormone secretion in adult and prepubertal female rats .
3250867	0	ethanol	23,30	growth_hormone	49,63	ethanol	growth hormone	MESH:D000431	2688	Chemical	Gene	exposure|compound|START_ENTITY effect|nmod|exposure effect|nmod|secretion secretion|compound|END_ENTITY	The effect of in vitro ethanol exposure on basal growth_hormone secretion .
356654	0	ethanol	64,71	growth_hormone	25,39	ethanol	growth hormone	MESH:D000431	2688	Chemical	Gene	intake|compound|START_ENTITY secretion|nmod|intake secretion|nsubj|suppression suppression|nmod|END_ENTITY	Transient suppression of growth_hormone secretion after chronic ethanol intake .
6273926	0	ethanol	10,17	growth_hormone	48,62	ethanol	growth hormone	MESH:D000431	2688	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of ethanol on spontaneous and stimulated growth_hormone secretion .
6374490	0	ethanol	19,26	growth_hormone	51,65	ethanol	growth hormone	MESH:D000431	81668(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY ingestion|nsubj|Effect ingestion|nmod|control control|nmod|secretion secretion|amod|END_ENTITY	Effect of maternal ethanol ingestion on control of growth_hormone secretion by biogenic amines in rat offspring .
6986815	0	ethanol	10,17	growth_hormone	43,57	ethanol	growth hormone	MESH:D000431	81668(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|amod|END_ENTITY	Effect of ethanol on endogenous rhythms of growth_hormone secretion .
7867559	0	ethanol	12,19	growth_hormone	55,69	ethanol	growth hormone	MESH:D000431	81668(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY suppresses|nsubj|administration suppresses|dobj|secretion secretion|compound|END_ENTITY	Acute , oral ethanol administration suppresses episodic growth_hormone secretion in the male rat .
8423543	0	ethanol	19,26	growth_hormone	30,44	ethanol	growth hormone	MESH:D000431	81668(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|amod|END_ENTITY	Effects of chronic ethanol on growth_hormone secretion and hepatic cytochrome P450 isozymes of the rat .
9267532	0	ethanol	16,23	growth_hormone	60,74	ethanol	growth hormone	MESH:D000431	81668(Tax:10116)	Chemical	Gene	exposure|compound|START_ENTITY exposure|nmod|release release|nmod|END_ENTITY	Effect of fetal ethanol exposure on the in vitro release of growth_hormone , somatostatin and growth_hormone-releasing factor induced by clonidine and growth_hormone feedback in male and female rats .
11173986	0	ethanol	118,125	iNOS	34,38	ethanol	iNOS	MESH:D000431	4843	Chemical	Gene	action|compound|START_ENTITY site|nmod|action evidence|nmod|site inhibits|parataxis|evidence inhibits|dobj|END_ENTITY	Ethanol inhibits cytokine-induced iNOS and sPLA2 in immortalized astrocytes : evidence for posttranscriptional site of ethanol action .
11454939	0	ethanol	82,89	iNOS	17,21	ethanol	iNOS	MESH:D000431	24599(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY expression|dep|inhibition expression|compound|END_ENTITY	Cytokine-induced iNOS expression in C6 glial cells : transcriptional inhibition by ethanol .
10442856	0	ethanol	78,85	inducible_nitric_oxide_synthase	27,58	ethanol	inducible nitric oxide synthase	MESH:D000431	4843	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Differential regulation of inducible_nitric_oxide_synthase gene expression by ethanol in the human intestinal epithelial cell line DLD-1 .
9727648	0	ethanol	146,153	inducible_nitric_oxide_synthase	40,71	ethanol	inducible nitric oxide synthase	MESH:D000431	4843	Chemical	Gene	macrophages|nmod|START_ENTITY macrophages|nsubj|mechanism mechanism|nmod|induction induction|nmod|mRNA mRNA|amod|END_ENTITY	The potential mechanism of induction of inducible_nitric_oxide_synthase mRNA in alveolar macrophages by lipopolysaccharide and its suppression by ethanol , in vivo .
10342340	0	ethanol	56,63	insulin	72,79	ethanol	insulin	MESH:D000431	3630	Chemical	Gene	dose|compound|START_ENTITY dose|nmod|action action|compound|END_ENTITY	Effect of different times of administration of a single ethanol dose on insulin action , insulin secretion and redox state .
12893459	0	ethanol	66,73	insulin	23,30	ethanol	insulin	MESH:D000431	3630	Chemical	Gene	oxidation|compound|START_ENTITY role|nmod|oxidation resistance|dep|role resistance|compound|END_ENTITY	Acute ethanol-mediated insulin resistance in the rat : the role of ethanol oxidation .
1435286	0	ethanol	64,71	insulin	104,111	ethanol	insulin	MESH:D000431	3630	Chemical	Gene	augmentation|compound|START_ENTITY indomethacin|nmod|augmentation influence|nmod|indomethacin influence|nmod|secretion secretion|compound|END_ENTITY	The influence of indomethacin , theophylline , and propranolol on ethanol augmentation of glucose-induced insulin secretion .
21845171	0	ethanol	22,29	insulin	45,52	ethanol	insulin	MESH:D000431	3630	Chemical	Gene	consumption|compound|START_ENTITY consumption|nmod|resistance resistance|compound|END_ENTITY	Beneficial effects of ethanol consumption on insulin resistance are only applicable to subjects without obesity or insulin resistance ; drinking is not necessarily a remedy for metabolic_syndrome .
2199967	0	ethanol	55,62	insulin	79,86	ethanol	insulin	MESH:D000431	3630	Chemical	Gene	augmentation|compound|START_ENTITY augmentation|nmod|END_ENTITY	Influence of naloxone , atropine , and metoclopramide on ethanol augmentation of insulin secretion after intravenous glucose stimulation .
4610627	0	ethanol	10,17	insulin	41,48	ethanol	insulin	MESH:D000431	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of ethanol and its metabolites on insulin secretion .
7978107	0	ethanol	8,15	insulin	34,41	ethanol	insulin	MESH:D000431	3630	Chemical	Gene	exposure|compound|START_ENTITY inhibits|nsubj|exposure inhibits|dobj|END_ENTITY	Chronic ethanol exposure inhibits insulin and IGF-1 stimulated amino_acid uptake in cultured human placental trophoblasts .
7978107	8	ethanol	836,843	insulin	931,938	ethanol	insulin	MESH:D000431	3630	Chemical	Gene	pretreatment|compound|START_ENTITY inhibited|nsubj|pretreatment inhibited|dobj|Na Na|amod|dependent dependent|ccomp|uptake uptake|nmod|END_ENTITY	However , 72-hr ethanol pretreatment of trophoblasts inhibited Na -LRB- + -RRB- - dependent AIB uptake under stimulation by insulin or IGF-1 in the absence of ethanol .
955303	0	ethanol	10,17	insulin	42,49	ethanol	insulin	MESH:D000431	397415(Tax:9823)	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	Effect of ethanol on the glucose-mediated insulin release in triply catheterized anesthetized pigs .
10069559	0	ethanol	11,18	insulin-like_growth_factor-1	39,67	ethanol	insulin-like growth factor-1	MESH:D000431	24482(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|system system|amod|END_ENTITY	Effects of ethanol on the intraovarian insulin-like_growth_factor-1 system in the prepubertal rat .
18666320	0	ethanol	11,18	insulin-like_growth_factor-I	22,50	ethanol	insulin-like growth factor-I	MESH:D000431	24482(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|system system|compound|END_ENTITY	Effects of ethanol on insulin-like_growth_factor-I system in primary cultured rat hepatocytes : implications of JNK1/2 _ and_alcoholdehydrogenase .
18277680	0	ethanol	101,108	insulin-like_growth_factor_1	12,40	ethanol	insulin-like growth factor 1	MESH:D000431	24482(Tax:10116)	Chemical	Gene	-RSB-|compound|START_ENTITY Effects|nmod|-RSB- Effects|nmod|END_ENTITY	-LSB- Effects of insulin-like_growth_factor_1 on inhibition of osteoblastic proliferation and function by ethanol -RSB- .
8749812	0	ethanol	10,17	insulin-like_growth_factor_1	38,66	ethanol	insulin-like growth factor 1	MESH:D000431	24482(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|synthesis synthesis|nmod|END_ENTITY	Effect of ethanol on the synthesis of insulin-like_growth_factor_1 -LRB- IGF-1 -RRB- and the IGF-1_receptor in late prepubertal female rats : a correlation with serum IGF-1 .
17555093	0	ethanol	19,26	insulin_receptor	37,53	ethanol	insulin receptor	MESH:D000431	24954(Tax:10116)	Chemical	Gene	intake|compound|START_ENTITY intake|nmod|END_ENTITY	-LSB- Effect of chronic ethanol intake on insulin_receptor , insulin_receptor subsrate-1 and phosphoinositide_3-kinase mRNA expression in skeletal muscle of rats -RSB- .
9279687	1	ethanol	106,113	interleukin-2	136,149	ethanol	interleukin-2	MESH:D000431	16183(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	I : Local injection of ethanol with a combination of interleukin-2 or microwaval hyperthermia for B16_melanomas with a size of less than 7 mm in diameter .
11791174	0	ethanol	30,37	interleukin-6	9,22	ethanol	interleukin-6	MESH:D000431	16193(Tax:10090)	Chemical	Gene	consumption|compound|START_ENTITY END_ENTITY|nmod|consumption	Elevated interleukin-6 during ethanol consumption acts as a potential endogenous protective cytokine against ethanol-induced apoptosis in the liver : involvement of induction of Bcl-2 and Bcl-x -LRB- L -RRB- proteins .
17331166	0	ethanol	74,81	interleukin-6	25,38	ethanol	interleukin-6	MESH:D000431	24498(Tax:10116)	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|Effect Effect|nmod|inducer inducer|nmod|END_ENTITY	Effect of the inducer of interleukin-6 -LRB- ME3738 -RRB- on rat liver treated with ethanol .
19107859	0	ethanol	126,133	interleukin-6	62,75	ethanol	interleukin-6	MESH:D000431	16193(Tax:10090)	Chemical	Gene	extract|compound|START_ENTITY extract|amod|END_ENTITY	Stimulation of osteoblastic differentiation and inhibition of interleukin-6 and nitric_oxide in MC3T3-E1 cells by pomegranate ethanol extract .
8724208	0	ethanol	72,79	interleukin-6	89,102	ethanol	interleukin-6	MESH:D000431	24498(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Quantitative reverse transcription polymerase chain reaction shows that ethanol enhances interleukin-6 mRNA expression in cultured mesangial cells .
15849819	0	ethanol	21,28	lipase	52,58	ethanol	lipase	MESH:D000431	291437(Tax:10116)	Chemical	Gene	consumption|compound|START_ENTITY consumption|nmod|END_ENTITY	Effects of long-term ethanol consumption on jejunal lipase and disaccharidase activities in male and female rats .
1226269	0	ethanol	10,17	lipoprotein_lipase	37,55	ethanol	lipoprotein lipase	MESH:D000431	24539(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|nmod|END_ENTITY	Effect of ethanol on the activity of lipoprotein_lipase in adipose tissue of male and female rats .
7197878	0	ethanol	19,26	liver_glycogen_phosphorylase	40,68	ethanol	liver glycogen phosphorylase	MESH:D000431	64035(Tax:10116)	Chemical	Gene	ingestion|compound|START_ENTITY ingestion|nmod|END_ENTITY	Effects of chronic ethanol ingestion on liver_glycogen_phosphorylase in male and female rats .
3129135	0	ethanol	6,13	luteinizing_hormone-releasing_hormone	57,94	ethanol	luteinizing hormone-releasing hormone	MESH:D000431	25194(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY lowers|nsubj|treatment lowers|dobj|END_ENTITY	Acute ethanol treatment lowers hypophyseal portal plasma luteinizing_hormone-releasing_hormone -LRB- LH-RH -RRB- and systemic plasma LH levels in orchidectomized rats .
18280564	0	ethanol	71,78	luteinizing_hormone_releasing_hormone	14,51	ethanol	luteinizing hormone releasing hormone	MESH:D000431	14714(Tax:10090)	Chemical	Gene	withdrawal_syndrome|compound|START_ENTITY withdrawal_syndrome|amod|agonist agonist|amod|END_ENTITY	Leuprolide : a luteinizing_hormone_releasing_hormone agonist attenuates ethanol withdrawal_syndrome and ethanol-induced locomotor sensitization in mice .
6347266	0	ethanol	11,18	luteinizing_hormone_releasing_hormone	39,76	ethanol	luteinizing hormone releasing hormone	MESH:D000431	25194(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of ethanol on rat hypothalamic luteinizing_hormone_releasing_hormone .
10716189	0	ethanol	75,82	lysozyme	43,51	ethanol	lysozyme	MESH:D000431	4069	Chemical	Gene	solution|compound|START_ENTITY END_ENTITY|dobj|solution	Amyloid protofilament formation of hen egg lysozyme in highly concentrated ethanol solution .
11514940	0	ethanol	60,67	lysozyme	40,48	ethanol	lysozyme	MESH:D000431	4069	Chemical	Gene	solution|compound|START_ENTITY END_ENTITY|nmod|solution	Denaturation and aggregation of hen egg lysozyme in aqueous ethanol solution studied by dynamic light scattering .
18558086	0	ethanol	72,79	lysozyme	47,55	ethanol	lysozyme	MESH:D000431	4069	Chemical	Gene	solution|compound|START_ENTITY END_ENTITY|nmod|solution	Characterization of amyloidogenesis of hen egg lysozyme in concentrated ethanol solution .
2407774	0	ethanol	11,18	lysozyme	48,56	ethanol	lysozyme	MESH:D000431	4069	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of ethanol on human monocyte/macrophage lysozyme storage and release .
9590515	0	ethanol	14,21	methionine_synthase	47,66	ethanol	methionine synthase	MESH:D000431	81522(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|amod|END_ENTITY	The effect of ethanol and its metabolites upon methionine_synthase activity in vitro .
8679013	0	ethanol	13,20	monoamine_oxidases	86,104	ethanol	monoamine oxidases	MESH:D000431	29253(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY Influence|nmod|administration END_ENTITY|nsubj|Influence	Influence of ethanol administration on the activity and compartmentation of rat liver monoamine_oxidases .
26156494	0	ethanol	82,89	myoglobin	61,70	ethanol	myoglobin	MESH:D000431	4151	Chemical	Gene	solution|compound|START_ENTITY END_ENTITY|nmod|solution	Composition dependent multiple structural transformations of myoglobin in aqueous ethanol solution : A combined experimental and theoretical study .
8129266	0	ethanol	13,20	nerve_growth_factor	42,61	ethanol	nerve growth factor	MESH:D000431	310738(Tax:10116)	Chemical	Gene	consumption|compound|START_ENTITY consumption|nmod|END_ENTITY	Influence of ethanol consumption on brain nerve_growth_factor and its target cells in developing and adult rodents .
18564106	0	ethanol	33,40	neuropeptide_S	15,29	ethanol	neuropeptide S	MESH:D000431	100360071	Chemical	Gene	drinking|compound|START_ENTITY END_ENTITY|nmod|drinking	The effects of neuropeptide_S on ethanol drinking and other related behaviors in alcohol-preferring and - nonpreferring rats .
11290849	0	ethanol	39,46	neuropeptide_Y	10,24	ethanol	neuropeptide Y	MESH:D000431	24604(Tax:10116)	Chemical	Gene	intake|compound|START_ENTITY END_ENTITY|nmod|intake	Effect of neuropeptide_Y -LRB- NPY -RRB- on oral ethanol intake in Wistar , alcohol-preferring -LRB- P -RRB- , and - nonpreferring -LRB- NP -RRB- rats .
15337375	0	ethanol	58,65	neuropeptide_Y	11,25	ethanol	neuropeptide Y	MESH:D000431	4852	Chemical	Gene	responses|nmod|START_ENTITY role|nmod|responses role|nmod|END_ENTITY	A role for neuropeptide_Y in neurobiological responses to ethanol and drugs of abuse .
20028355	0	ethanol	52,59	neuropeptide_Y	23,37	ethanol	neuropeptide Y	MESH:D000431	24604(Tax:10116)	Chemical	Gene	system|nmod|START_ENTITY system|amod|END_ENTITY	Gene expression in the neuropeptide_Y system during ethanol withdrawal_kindling in rats .
10386828	0	ethanol	27,34	nitric_oxide_synthase	47,68	ethanol	nitric oxide synthase	MESH:D000431	100135576(Tax:10141)	Chemical	Gene	exposure|compound|START_ENTITY exposure|nmod|I I|amod|END_ENTITY	Effect of chronic prenatal ethanol exposure on nitric_oxide_synthase I and III proteins in the hippocampus of the near-term fetal guinea_pig .
11373254	0	ethanol	106,113	nitric_oxide_synthase	19,40	ethanol	nitric oxide synthase	MESH:D000431	18125(Tax:10090)	Chemical	Gene	administration|compound|START_ENTITY inhibitor|nmod|administration inhibitor|nsubj|effects effects|nmod|END_ENTITY	The effects of the nitric_oxide_synthase inhibitor 7-nitroindazole on the behaviour of mice after chronic ethanol administration .
14998824	0	ethanol	69,76	nitric_oxide_synthase	6,27	ethanol	nitric oxide synthase	MESH:D000431	100135576(Tax:10141)	Chemical	Gene	exposure|compound|START_ENTITY increase|nmod|exposure increase|nsubj|levels levels|compound|END_ENTITY	Brain nitric_oxide_synthase levels increase in response to antenatal ethanol exposure .
7525932	0	ethanol	30,37	nitric_oxide_synthase	84,105	ethanol	nitric oxide synthase	MESH:D000431	4843	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	Magnesium and zinc potentiate ethanol inhibition of N-methyl-D-aspartate-stimulated nitric_oxide_synthase in cortical neurons .
8865973	0	ethanol	27,34	nitric_oxide_synthase	53,74	ethanol	nitric oxide synthase	MESH:D000431	100135576(Tax:10141)	Chemical	Gene	administration|compound|START_ENTITY administration|nmod|activity activity|amod|END_ENTITY	Effect of chronic maternal ethanol administration on nitric_oxide_synthase activity in the hippocampus of the mature fetal guinea_pig .
9103544	0	ethanol	15,22	nitric_oxide_synthase	36,57	ethanol	nitric oxide synthase	MESH:D000431	4843	Chemical	Gene	Suppression|nmod|START_ENTITY END_ENTITY|nsubj|Suppression	Suppression by ethanol of inducible nitric_oxide_synthase expression in C6 glioma cells .
9554946	0	ethanol	87,94	nitric_oxide_synthase	12,33	ethanol	nitric oxide synthase	MESH:D000431	100135576(Tax:10141)	Chemical	Gene	exposure|compound|START_ENTITY effects|nmod|exposure END_ENTITY|dep|effects	Hippocampal nitric_oxide_synthase in the fetal guinea_pig : effects of chronic prenatal ethanol exposure .
423260	0	ethanol	11,18	ornithine_decarboxylase	50,73	ethanol	ornithine decarboxylase	MESH:D000431	4953	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|compound|END_ENTITY	Effects of ethanol and acetaldehyde on myocardial ornithine_decarboxylase activity .
19251116	0	ethanol	22,29	parvalbumin	42,53	ethanol	parvalbumin	MESH:D000431	396531(Tax:9031)	Chemical	Gene	exposure|compound|START_ENTITY exposure|nmod|END_ENTITY	Effect of gestational ethanol exposure on parvalbumin and calretinin expressing hippocampal neurons in a chick model of fetal_alcohol_syndrome .
11255124	0	ethanol	13,20	phospholipase_A2	75,91	ethanol	phospholipase A2	MESH:D000431	151056	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|activity activity|nmod|END_ENTITY	Influence of ethanol and phosphatidylethanol on the activity of pancreatic phospholipase_A2 .
1518381	0	ethanol	10,17	phospholipase_A2	30,46	ethanol	phospholipase A2	MESH:D000431	151056	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of ethanol on platelet phospholipase_A2 .
1764451	0	ethanol	8,15	phospholipase_A2	118,134	ethanol	phospholipase A2	MESH:D000431	151056	Chemical	Gene	ingestion|compound|START_ENTITY modifies|nsubj|ingestion modifies|dobj|phosphatidylserine phosphatidylserine|acl|inducing inducing|nmod|hydrolysis hydrolysis|nmod|END_ENTITY	Chronic ethanol ingestion modifies liver microsomal phosphatidylserine inducing resistance to hydrolysis by exogenous phospholipase_A2 .
7820065	0	ethanol	24,31	phospholipase_A2	40,56	ethanol	phospholipase A2	MESH:D000431	18784(Tax:10090)	Chemical	Gene	START_ENTITY|acl|induced induced|dobj|activity activity|amod|END_ENTITY	Ganglioside_GM1 reduces ethanol induced phospholipase_A2 activity in synaptosomal preparations from mice .
8534222	0	ethanol	18,25	phospholipase_A2	29,45	ethanol	phospholipase A2	MESH:D000431	426748(Tax:9031)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|heart heart|amod|END_ENTITY	Effect of chronic ethanol on phospholipase_A2 - and C-activity in chick embryo brain , heart and liver .
9514087	0	ethanol	18,25	phospholipase_A2	76,92	ethanol	phospholipase A2	MESH:D000431	18784(Tax:10090)	Chemical	Gene	exposure|compound|START_ENTITY Effect|nmod|exposure arachidonic_acid|nsubj|Effect arachidonic_acid|dobj|END_ENTITY	Effect of chronic ethanol exposure on mouse brain arachidonic_acid specific phospholipase_A2 .
11822824	0	ethanol	28,35	prolactin	48,57	ethanol	prolactin	MESH:D000431	24683(Tax:10116)	Chemical	Gene	exposure|compound|START_ENTITY Impact|nmod|exposure Impact|nmod|END_ENTITY	Impact of acute and chronic ethanol exposure on prolactin in both male and female rats .
1399693	0	ethanol	19,26	prolactin	30,39	ethanol	prolactin	MESH:D000431	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|hormone hormone|compound|END_ENTITY	In vivo studies of ethanol on prolactin and luteinizing hormone in rats and mice .
1798856	0	ethanol	17,24	prolactin	38,47	ethanol	prolactin	MESH:D000431	24683(Tax:10116)	Chemical	Gene	action|nmod|START_ENTITY action|nmod|secretion secretion|compound|END_ENTITY	Direct action of ethanol on pituitary prolactin secretion in vitro .
1805295	0	ethanol	36,43	prolactin	6,15	ethanol	prolactin	MESH:D000431	5617	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|increase increase|compound|END_ENTITY	Serum prolactin increase induced by ethanol -- a dose-dependent effect not related to stress .
2123447	0	ethanol	14,21	prolactin	30,39	ethanol	prolactin	MESH:D000431	24683(Tax:10116)	Chemical	Gene	Evidence|dep|START_ENTITY induces|nsubj|Evidence induces|dobj|secretion secretion|compound|END_ENTITY	Evidence that ethanol induces prolactin secretion in GH4C1 cells by producing cell swelling with resultant calcium influx .
2641833	0	ethanol	57,64	prolactin	16,25	ethanol	prolactin	MESH:D000431	24683(Tax:10116)	Chemical	Gene	administration|nmod|START_ENTITY levels|nmod|administration levels|compound|END_ENTITY	-LSB- Changes in the prolactin levels after administration of ethanol in diestrus 2 -RSB- .
3829449	0	ethanol	13,20	prolactin	63,72	ethanol	prolactin	MESH:D000431	100303694(Tax:9103)	Chemical	Gene	treatment|compound|START_ENTITY Influence|nmod|treatment Influence|nmod|concentrations concentrations|nmod|hormone hormone|compound|END_ENTITY	Influence of ethanol treatment on the plasma concentrations of prolactin and luteinizing hormone in turkeys -LRB- Meleagris_gallopavo -RRB- .
6493000	0	ethanol	14,21	prolactin	25,34	ethanol	prolactin	MESH:D000431	5617	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|compound|END_ENTITY	The effect of ethanol on prolactin secretion in vitro .
7375492	0	ethanol	16,23	prolactin	55,64	ethanol	prolactin	MESH:D000431	5617	Chemical	Gene	ingestion|compound|START_ENTITY ingestion|nmod|levels levels|compound|END_ENTITY	Effect of acute ethanol ingestion on integrated plasma prolactin levels in normal men .
7890253	0	ethanol	16,23	prolactin	37,46	ethanol	prolactin	MESH:D000431	5617	Chemical	Gene	ingestion|compound|START_ENTITY ingestion|nmod|END_ENTITY	Effect of acute ethanol ingestion on prolactin in menopausal women using estradiol replacement .
8107524	0	ethanol	56,63	prolactin	71,80	ethanol	prolactin	MESH:D000431	5617	Chemical	Gene	effect|nmod|START_ENTITY mediation|nmod|effect opioid|dobj|mediation opioid|nmod|response response|compound|END_ENTITY	Endogenous opioid mediation of the inhibitory effect of ethanol on the prolactin response to breast stimulation in normal women .
25072633	0	ethanol	53,60	proopiomelanocortin	14,33	ethanol	proopiomelanocortin	MESH:D000431	18976(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Modulation of proopiomelanocortin gene expression by ethanol in mouse anterior pituitary corticotrope_tumor cell AtT20 .
8986194	0	ethanol	23,30	protein_kinase_C	34,50	ethanol	protein kinase C	MESH:D000431	112476	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of administered ethanol on protein_kinase_C in human platelets .
14556642	0	ethanol	11,18	protein_kinase_C_alpha	22,44	ethanol	protein kinase C alpha	MESH:D000431	5578	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Effects of ethanol on protein_kinase_C_alpha activity induced by association with Rho GTPases .
12427847	0	ethanol	57,64	protein_kinase_C_epsilon	22,46	ethanol	protein kinase C epsilon	MESH:D000431	18754(Tax:10090)	Chemical	Gene	preference|compound|START_ENTITY regulates|dobj|preference regulates|nsubj|rescue rescue|nmod|END_ENTITY	Conditional rescue of protein_kinase_C_epsilon regulates ethanol preference and hypnotic sensitivity in adult mice .
19225761	0	ethanol	69,76	protein_kinase_C_epsilon	8,32	ethanol	protein kinase C epsilon	MESH:D000431	29340(Tax:10116)	Chemical	Gene	reinforcement|compound|START_ENTITY reduction|nmod|reinforcement Role|nmod|reduction Role|nmod|END_ENTITY	Role of protein_kinase_C_epsilon -LRB- PKCvarepsilon -RRB- in the reduction of ethanol reinforcement due to mGluR5 antagonism in the nucleus accumbens shell .
17623767	5	ethanol	813,820	rats	834,838	ethanol	VEGF	MESH:D000431	83785(Tax:10116)	Chemical	Gene	ingestion|compound|START_ENTITY ingestion|nmod|END_ENTITY	The results show that systolic , diastolic and mean BP was significantly elevated 12 weeks after ethanol ingestion in rats compared to control .
11759826	0	ethanol	61,68	rpL7a	51,56	ethanol	rpL7a	MESH:D000431	6130	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|appos|END_ENTITY	Modulation of expression of ribosomal_protein_L7a -LRB- rpL7a -RRB- by ethanol in human breast_cancer cells .
12667901	0	ethanol	67,74	sigma_1_receptor	19,35	ethanol	sigma 1 receptor	MESH:D000431	18391(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nmod|effects	Involvement of the sigma_1_receptor in the motivational effects of ethanol in mice .
9367825	0	ethanol	31,38	signal_transducer_and_activator_transcription_factor_3	60,114	ethanol	signal transducer and activator transcription factor 3	MESH:D000431	25125(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Effects of short and long term ethanol on the activation of signal_transducer_and_activator_transcription_factor_3 in normal and regenerating liver .
3224537	0	ethanol	66,73	somatomedin	35,46	ethanol	somatomedin	MESH:D000431	16000(Tax:10090)	Chemical	Gene	administration|compound|START_ENTITY END_ENTITY|nmod|administration	Mouse placental receptor for basic somatomedin following maternal ethanol administration .
3122774	0	ethanol	10,17	somatomedin_C	45,58	ethanol	somatomedin C	MESH:D000431	3479	Chemical	Gene	START_ENTITY|nmod|concentrations concentrations|nmod|END_ENTITY	Effect of ethanol on serum concentrations of somatomedin_C and the growth_hormone -LRB- GH -RRB- secretion stimulated by the releasing hormone -LRB- GHRH -RRB- .
11821660	0	ethanol	31,38	steroidogenic_acute_regulatory_protein	57,95	ethanol	steroidogenic acute regulatory protein	MESH:D000431	25557(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY administration|nmod|END_ENTITY	Chronic effects of prepubertal ethanol administration on steroidogenic_acute_regulatory_protein in the rat ovary .
16584974	0	ethanol	10,17	steroidogenic_acute_regulatory_protein	58,96	ethanol	steroidogenic acute regulatory protein	MESH:D000431	25557(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY stimulating|nsubj|Effect stimulating|dobj|END_ENTITY	Effect of ethanol on follicle stimulating hormone-induced steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- in cultured rat granulosa cells .
9161404	0	ethanol	68,75	tracheo-bronchial_mucin	30,53	ethanol	tracheo-bronchial mucin	MESH:D000431	4586	Chemical	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Transcriptional regulation of tracheo-bronchial_mucin -LRB- TBM -RRB- gene by ethanol .
454365	0	ethanol	58,65	tryptophan_pyrrolase	125,145	ethanol	tryptophan pyrrolase	MESH:D000431	64206(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY administration|nmod|activity activity|compound|END_ENTITY	Enhancement of rat brain tryptophan metabolism by chronic ethanol administration and possible involvement of decreased liver tryptophan_pyrrolase activity .
24093781	0	ethanol	93,100	tumor_necrosis_factor-a	110,133	ethanol	tumor necrosis factor-a	MESH:D000431	24835(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|advcl|END_ENTITY	Study on the antiulcer effects of Veronicastrum axillare on gastric ulcer in rats induced by ethanol based on tumor_necrosis_factor-a -LRB- TNF-a -RRB- and endothelin-1 -LRB- ET-1 -RRB- .
11981130	0	ethanol	20,27	tumor_necrosis_factor-alpha	31,58	ethanol	tumor necrosis factor-alpha	MESH:D000431	7124	Chemical	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Effects of in vitro ethanol on tumor_necrosis_factor-alpha production by blood obtained from simian_immunodeficiency_virus-infected rhesus_macaques .
15318101	0	ethanol	52,59	tumor_necrosis_factor-alpha	110,137	ethanol	tumor necrosis factor-alpha	MESH:D000431	24835(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nmod|suppression suppression|nmod|END_ENTITY	Pioglitazone prevents acute_liver_injury induced by ethanol and lipopolysaccharide through the suppression of tumor_necrosis_factor-alpha .
15596091	0	ethanol	88,95	tumor_necrosis_factor-alpha	17,44	ethanol	tumor necrosis factor-alpha	MESH:D000431	7124	Chemical	Gene	exposure|compound|START_ENTITY Stabilization|nmod|exposure Stabilization|nmod|mRNA mRNA|amod|END_ENTITY	Stabilization of tumor_necrosis_factor-alpha mRNA in macrophages in response to chronic ethanol exposure .
17974145	0	ethanol	19,26	tumor_necrosis_factor-alpha	73,100	ethanol	tumor necrosis factor-alpha	MESH:D000431	24835(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of chronic ethanol and vitamin_C administration on production of tumor_necrosis_factor-alpha and interleukin-6 in rats .
8514256	0	ethanol	10,17	tumor_necrosis_factor-alpha	89,116	ethanol	tumor necrosis factor-alpha	MESH:D000431	24835(Tax:10116)	Chemical	Gene	consumption|compound|START_ENTITY alters|nsubj|consumption alters|nmod|effects effects|nmod|END_ENTITY	Long-term ethanol consumption alters the hepatic response to the regenerative effects of tumor_necrosis_factor-alpha .
8865966	0	ethanol	48,55	tumor_necrosis_factor-alpha	77,104	ethanol	tumor necrosis factor-alpha	MESH:D000431	7124	Chemical	Gene	treatment|compound|START_ENTITY functions|nmod|treatment Regulation|nmod|functions Regulation|dep|END_ENTITY	Regulation of human monocyte functions by acute ethanol treatment : decreased tumor_necrosis_factor-alpha , interleukin-1_beta and elevated interleukin-10 , and transforming_growth_factor-beta production .
9514300	0	ethanol	119,126	tumor_necrosis_factor-alpha	10,37	ethanol	tumor necrosis factor-alpha	MESH:D000431	24835(Tax:10116)	Chemical	Gene	consumption|compound|START_ENTITY cells|nmod|consumption Decreased|nmod|cells Decreased|dobj|production production|amod|END_ENTITY	Decreased tumor_necrosis_factor-alpha and interleukin-1alpha production from intrahepatic mononuclear cells in chronic ethanol consumption and upregulation by endotoxin .
9727642	0	ethanol	8,15	tumor_necrosis_factor-alpha	54,81	ethanol	tumor necrosis factor-alpha	MESH:D000431	24835(Tax:10116)	Chemical	Gene	consumption|compound|START_ENTITY induces|nsubj|consumption induces|dobj|production production|nmod|cytokines cytokines|amod|END_ENTITY	Chronic ethanol consumption induces the production of tumor_necrosis_factor-alpha and related cytokines in liver and adipose tissue .
11551956	0	ethanol	61,68	tumor_necrosis_factor_alpha	17,44	ethanol	tumor necrosis factor alpha	MESH:D000431	21926(Tax:10090)	Chemical	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	Stabilization of tumor_necrosis_factor_alpha mRNA by chronic ethanol : role of A + U-rich elements and p38 mitogen-activated protein kinase signaling pathway .
9476960	0	ethanol	41,48	tyrosine_aminotransferase	77,102	ethanol	tyrosine aminotransferase	MESH:D000431	24813(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY effects|nmod|administration END_ENTITY|nsubj|effects	Contrasting effects of acute and chronic ethanol administration on rat liver tyrosine_aminotransferase .
6112782	0	ethanol	33,40	vasoactive_intestinal_peptide	160,189	ethanol	vasoactive intestinal peptide	MESH:D000431	7432	Chemical	Gene	Relationship|nmod|START_ENTITY END_ENTITY|nsubj|Relationship	Relationship between intravenous ethanol , alcohol-induced inhibition of pancreatic secretion and plasma concentration of immunoreactive pancreatic polypeptide , vasoactive_intestinal_peptide , and somatostatin in man .
15203290	0	ethanol	107,114	vasopressin	9,20	ethanol	vasopressin	MESH:D000431	551	Chemical	Gene	attenuated|nmod|START_ENTITY attenuated|nsubjpass|END_ENTITY	Arginine vasopressin and adrenocorticotropin secretion in response to psychosocial stress is attenuated by ethanol in sons of alcohol-dependent fathers .
173829	0	ethanol	10,17	vasopressin	125,136	ethanol	vasopressin	MESH:D000431	551	Chemical	Gene	Effect|nmod|START_ENTITY Effect|acl|END_ENTITY	Effect of ethanol on the water permeability and short-circuit current of the urinary bladder of the toad and the response to vasopressin , adenosine-3 ' ,5 ' - monophosphate and theophylline .
362827	0	ethanol	22,29	vasopressin	7,18	ethanol	vasopressin	MESH:D000431	551	Chemical	Gene	intoxication|compound|START_ENTITY END_ENTITY|nmod|intoxication	Plasma vasopressin in ethanol intoxication and hangover .
7081477	0	ethanol	10,17	vasopressin	38,49	ethanol	vasopressin	MESH:D000431	551	Chemical	Gene	ingestion|compound|START_ENTITY Effect|nmod|ingestion Effect|nmod|END_ENTITY	Effect of ethanol ingestion on plasma vasopressin and water balance in humans .
8145895	0	ether	63,68	prolactin	22,31	ether	prolactin	MESH:D004986	24683(Tax:10116)	Chemical	Gene	Analysis|nmod|START_ENTITY Analysis|nmod|END_ENTITY	Analysis of pituitary prolactin and adrenocortical response to ether , formalin or restraint in lactating rats : rise in corticosterone , but no increase in plasma prolactin levels after exposure to stress .
3446203	0	ethidium_bromide	43,59	butyrylcholinesterase	18,39	ethidium bromide	butyrylcholinesterase	MESH:D004996	590	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of the butyrylcholinesterase by ethidium_bromide .
9806355	0	ethinyl_estradiol	39,56	Cyclin_A2	0,9	ethinyl estradiol	Cyclin A2	MESH:D004997	114494(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Cyclin_A2 and c-myc mRNA expression in ethinyl_estradiol induced liver proliferation .
20403194	0	ethinyl_estradiol	121,138	GPR30	0,5	ethinyl estradiol	GPR30	MESH:D004997	76854(Tax:10090)	Chemical	Gene	crucial|nmod|START_ENTITY crucial|nsubj|END_ENTITY	GPR30 , but not estrogen_receptor-alpha , is crucial in the treatment of experimental_autoimmune_encephalomyelitis by oral ethinyl_estradiol .
925482	0	ethinyl_estradiol	11,28	cytochrome_P-450	80,96	ethinyl estradiol	cytochrome P-450	MESH:D004997	4051	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of ethinyl_estradiol on hepatic microsomal proteins and the turnover of cytochrome_P-450 .
6987956	0	ethinyl_estradiol	10,27	renin	31,36	ethinyl estradiol	renin	MESH:D004997	5972	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Effect of ethinyl_estradiol on renin activity and on the concentrations of renin substrate and aldosterone in plasma of ovariectomized women .
76285	1	ethionine	113,122	Alpha-fetoprotein	82,99	ethionine	Alpha-fetoprotein	MESH:D005001	174	Chemical	Gene	induction|nmod|START_ENTITY induction|nsubj|END_ENTITY	I. Alpha-fetoprotein induction by ethionine .
25446111	0	ethionine	72,81	GPR120	20,26	ethionine	GPR120	MESH:D005001	294075(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|effects effects|nmod|END_ENTITY	Opposite effects of GPR120 and GPR40 on cell motile activity induced by ethionine in liver epithelial cells .
8357931	0	ethionine	52,61	haptoglobin	19,30	ethionine	haptoglobin	MESH:D005001	280692(Tax:9913)	Chemical	Gene	administration|nmod|START_ENTITY END_ENTITY|nmod|administration	Induction of serum haptoglobin by administration of ethionine to cows .
22728103	0	ethosuximide	52,64	Ts65Dn	97,103	ethosuximide	Ts65Dn	MESH:D005013	21101(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|model model|amod|END_ENTITY	Lack of behavioral and cognitive effects of chronic ethosuximide and gabapentin treatment in the Ts65Dn mouse model of Down_syndrome .
21135154	0	ethoxidine	23,33	topoisomerase_I	37,52	ethoxidine	topoisomerase I	MESH:C404513	7150	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Paradoxical effects of ethoxidine , a topoisomerase_I inhibitor , in the cellular processes leading to angiogenesis on endothelial cells .
20659802	0	ethyl_2-amino-4-phenylthiazole-5-carboxylates	56,101	adenosine_A2A_receptor	111,133	ethyl 2-amino-4-phenylthiazole-5-carboxylates	adenosine A2A receptor	null	135	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|amod|END_ENTITY	Hit-to-lead optimization of a series of carboxamides of ethyl_2-amino-4-phenylthiazole-5-carboxylates as novel adenosine_A2A_receptor antagonists .
21656334	0	ethyl_acetate	17,30	iNOS	75,79	ethyl acetate	iNOS	MESH:C007650	18126(Tax:10090)	Chemical	Gene	inhibits|dep|START_ENTITY inhibits|nsubj|END_ENTITY	Phellinus baumii ethyl_acetate extract inhibits lipopolysaccharide-induced iNOS , COX-2 , and proinflammatory cytokine expression in RAW264 .7 cells .
21316417	0	ethyl_pyruvate	49,63	MMP-9	24,29	ethyl pyruvate	MMP-9	MESH:C046522	4318	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Inhibitory mechanism of MMP-9 gene expression by ethyl_pyruvate in lipopolysaccharide-stimulated BV2 microglial cells .
18067720	0	ethyl_pyruvate	11,25	high_mobility_group_box-1	35,60	ethyl pyruvate	high mobility group box-1	MESH:C046522	25459(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	-LSB- Effect of ethyl_pyruvate on renal high_mobility_group_box-1 protein expression and acute kidney_injury in rats with delayed resuscitation after thermal_injury -RSB- .
8605197	0	ethyl_sulfide	57,70	thioether_S-methyltransferase	24,53	ethyl sulfide	thioether S-methyltransferase	CHEBI:27710	11185	Chemical	Gene	inactivation|nmod|START_ENTITY inactivation|nmod|END_ENTITY	Suicide inactivation of thioether_S-methyltransferase by ethyl_sulfide .
6108931	0	ethylamide	67,77	LHRH	23,27	ethylamide	LHRH	null	2796	Chemical	Gene	START_ENTITY|nsubj|activity activity|nmod|END_ENTITY	Luteolytic activity of LHRH and -LSB- D-Ser -LRB- TBU -RRB- 6 , des-Gly-NH2 -LRB- 10 -RRB- -RSB- LHRH ethylamide : a new and physiological approach to contraception in women .
338901	0	ethylamide	12,22	luteinizing_hormone-releasing_hormone	41,78	ethylamide	luteinizing hormone-releasing hormone	null	25194(Tax:10116)	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|nmod|END_ENTITY	Nonapeptide ethylamide inhibitors of the luteinizing_hormone-releasing_hormone -LRB- LH-RH -RRB- having a D-alanyl residue in position 6 and variations at positions 2 and 3 .
14617075	0	ethylene	36,44	AtGSTF2	12,19	ethylene	AtGSTF2	MESH:C036216	827931(Tax:3702)	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Arabidopsis AtGSTF2 is regulated by ethylene and auxin , and encodes a glutathione_S-transferase that interacts with flavonoids .
14984929	4	ethylene	668,676	AtGSTF2	631,638	ethylene	AtGSTF2	MESH:C036216	827931(Tax:3702)	Chemical	Gene	sensitive|nmod|START_ENTITY sensitive|nsubj|gene gene|amod|END_ENTITY	A subsequent RNA expression study revealed that the AtGSTF2 gene was highly sensitive to ethylene , whereas the transcripts for AtGSTF8 and AtGSTU19 were constitutively present in new root tissue of 4-day-old seedlings .
9560288	0	ethylene	74,82	ERS	70,73	ethylene	ERS	MESH:C036216	836526(Tax:3702)	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Association of the Arabidopsis CTR1 Raf-like kinase with the ETR1 and ERS ethylene receptors .
20374664	0	ethylene	70,78	ERS1	65,69	ethylene	ERS1	MESH:C036216	818693(Tax:3702)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Genetic and transformation studies reveal negative regulation of ERS1 ethylene receptor signaling in Arabidopsis .
25988998	0	ethylene	149,157	ERS1	67,71	ethylene	ERS1	MESH:C036216	818693(Tax:3702)	Chemical	Gene	response|compound|START_ENTITY magnitude|nmod|response regulating|dobj|magnitude suggest|advcl|regulating suggest|nsubj|mutations mutations|nmod|III III|nmod|END_ENTITY	Dominant gain-of-function mutations in transmembrane domain III of ERS1 and ETR1 suggest a novel role for this domain in regulating the magnitude of ethylene response in Arabidopsis .
10482685	0	ethylene	107,115	ETR1	102,106	ethylene	ETR1	MESH:C036216	852314(Tax:4932)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	The relationship between ethylene binding and dominant insensitivity conferred by mutant forms of the ETR1 ethylene receptor .
10482685	0	ethylene	25,33	ETR1	102,106	ethylene	ETR1	MESH:C036216	852314(Tax:4932)	Chemical	Gene	relationship|nmod|START_ENTITY conferred|nsubj|relationship conferred|nmod|forms forms|nmod|receptor receptor|compound|END_ENTITY	The relationship between ethylene binding and dominant insensitivity conferred by mutant forms of the ETR1 ethylene receptor .
10890532	0	ethylene	36,44	ETR1	64,68	ethylene	ETR1	MESH:C036216	842951(Tax:3702)	Chemical	Gene	START_ENTITY|nmod|accumulation accumulation|nmod|transcripts transcripts|nummod|END_ENTITY	Effect of pollination and exogenous ethylene on accumulation of ETR1 homologue transcripts during flower petal abscission in geranium -LRB- Pelargonium_x_hortorum L.H. Bailey -RRB- .
11340179	3	ethylene	888,896	ETR1	864,868	ethylene	CEV1	MESH:C036216	830399(Tax:3702)	Chemical	Gene	receptor|compound|START_ENTITY encodes|dobj|receptor END_ENTITY|acl:relcl|encodes	Genetic evidence indicated that the cev1 phenotype required both COI1 , an essential component of the JA signal pathway , and ETR1 , which encodes the ethylene receptor .
11916973	0	ethylene	20,28	ETR1	38,42	ethylene	ETR1	MESH:C036216	842951(Tax:3702)	Chemical	Gene	receptor|compound|START_ENTITY Localization|nmod|receptor END_ENTITY|nsubj|Localization	Localization of the ethylene receptor ETR1 to the endoplasmic reticulum of Arabidopsis .
12177468	0	ethylene	112,120	ETR1	52,56	ethylene	ETR1	MESH:C036216	842951(Tax:3702)	Chemical	Gene	enhanced|nmod|START_ENTITY enhanced|nsubj|mutations mutations|nmod|cause cause|compound|END_ENTITY	Loss-of-function mutations in the ethylene receptor ETR1 cause enhanced sensitivity and exaggerated response to ethylene in Arabidopsis .
12177468	0	ethylene	34,42	ETR1	52,56	ethylene	ETR1	MESH:C036216	842951(Tax:3702)	Chemical	Gene	cause|compound|START_ENTITY cause|compound|END_ENTITY	Loss-of-function mutations in the ethylene receptor ETR1 cause enhanced sensitivity and exaggerated response to ethylene in Arabidopsis .
12481081	0	ethylene	10,18	ETR1	78,82	ethylene	ETR1	MESH:C036216	842951(Tax:3702)	Chemical	Gene	Effect|nmod|START_ENTITY mutations|nsubj|Effect mutations|nmod|expression expression|nmod|END_ENTITY	Effect of ethylene pathway mutations upon expression of the ethylene receptor ETR1 from Arabidopsis .
12509505	0	ethylene	74,82	ETR1	69,73	ethylene	ETR1	MESH:C036216	842951(Tax:3702)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Canonical histidine kinase activity of the transmitter domain of the ETR1 ethylene receptor from Arabidopsis is not required for signal transmission .
14680944	0	ethylene	50,58	ETR1	76,80	ethylene	ETR1	MESH:C036216	842951(Tax:3702)	Chemical	Gene	protein|compound|START_ENTITY expression|nmod|protein END_ENTITY|nsubj|expression	High-level expression of the Arabidopsis_thaliana ethylene receptor protein ETR1 in Escherichia_coli and purification of the recombinant protein .
17931631	0	ethylene	62,70	ETR1	86,90	ethylene	ETR1	MESH:C036216	842951(Tax:3702)	Chemical	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	The effects of Group 11 transition metals , including gold , on ethylene binding to the ETR1 receptor and growth of Arabidopsis_thaliana .
18643990	0	ethylene	61,69	ETR1	56,60	ethylene	ETR1	MESH:C036216	842951(Tax:3702)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Involvement of RTE1 in conformational changes promoting ETR1 ethylene receptor signaling in Arabidopsis .
19769567	0	ethylene	31,39	ETR1	130,134	ethylene	ETR1	MESH:C036216	842951(Tax:3702)	Chemical	Gene	signalling|compound|START_ENTITY regulator|nmod|signalling EIN2|appos|regulator localized|nsubj|EIN2 localized|advcl|interacts interacts|nmod|END_ENTITY	EIN2 , the central regulator of ethylene signalling , is localized at the ER membrane where it interacts with the ethylene receptor ETR1 .
20952388	0	ethylene	46,54	ETR1	41,45	ethylene	ETR1	MESH:C036216	842951(Tax:3702)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Molecular association of the Arabidopsis ETR1 ethylene receptor and a regulator of ethylene signaling , RTE1 .
20952388	0	ethylene	83,91	ETR1	41,45	ethylene	ETR1	MESH:C036216	842951(Tax:3702)	Chemical	Gene	association|nmod|START_ENTITY association|nmod|receptor receptor|compound|END_ENTITY	Molecular association of the Arabidopsis ETR1 ethylene receptor and a regulator of ethylene signaling , RTE1 .
22227969	0	ethylene	53,61	ETR1	12,16	ethylene	ETR1	MESH:C036216	842951(Tax:3702)	Chemical	Gene	response|compound|START_ENTITY repress|dobj|response repress|nsubj|END_ENTITY	Arabidopsis ETR1 and ERS1 differentially repress the ethylene response in combination with other ethylene receptor genes .
22227969	0	ethylene	97,105	ETR1	12,16	ethylene	ETR1	MESH:C036216	842951(Tax:3702)	Chemical	Gene	genes|compound|START_ENTITY repress|nmod|genes repress|nsubj|END_ENTITY	Arabidopsis ETR1 and ERS1 differentially repress the ethylene response in combination with other ethylene receptor genes .
22467798	0	ethylene	72,80	ETR1	51,55	ethylene	ETR1	MESH:C036216	842951(Tax:3702)	Chemical	Gene	response|compound|START_ENTITY facilitates|dobj|response facilitates|nsubj|activity activity|nmod|END_ENTITY	Histidine kinase activity of the ethylene receptor ETR1 facilitates the ethylene response in Arabidopsis .
22566492	0	ethylene	33,41	ETR1	51,55	ethylene	ETR1	MESH:C036216	842951(Tax:3702)	Chemical	Gene	amino-terminal|compound|START_ENTITY amino-terminal|compound|END_ENTITY	Arabidopsis RTE1 is essential to ethylene receptor ETR1 amino-terminal signaling independent of CTR1 .
24192376	0	ethylene	100,108	ETR1	118,122	ethylene	ETR1	MESH:C036216	842951(Tax:3702)	Chemical	Gene	receptor|compound|START_ENTITY domain|nmod|receptor analysis|nmod|domain END_ENTITY|nsubj|analysis	Cloning , overexpression , purification and preliminary X-ray analysis of the catalytic domain of the ethylene receptor ETR1 from Arabidopsis_thaliana .
24635651	0	ethylene	39,47	ETR1	34,38	ethylene	ETR1	MESH:C036216	842951(Tax:3702)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Association of cytochrome b5 with ETR1 ethylene receptor signaling through RTE1 in Arabidopsis .
25221561	0	ethylene	17,25	ETR1	12,16	ethylene	ETR1	MESH:C036216	842951(Tax:3702)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Loss of the ETR1 ethylene receptor reduces the inhibitory effect of far-red light and darkness on seed germination of Arabidopsis_thaliana .
9636235	0	ethylene	38,46	ETR1	33,37	ethylene	ETR1	MESH:C036216	842951(Tax:3702)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Histidine kinase activity of the ETR1 ethylene receptor from Arabidopsis .
9761877	0	ethylene	101,109	ETR1	92,96	ethylene	ETR1	MESH:C036216	842951(Tax:3702)	Chemical	Gene	receptor|compound|START_ENTITY analysis|appos|receptor analysis|nmod|domain domain|nmod|END_ENTITY	Subcloning , crystallization and preliminary X-ray analysis of the signal receiver domain of ETR1 , an ethylene receptor from Arabidopsis_thaliana .
24631536	0	ethylene	24,32	GDSL_lipase_1	0,13	ethylene	GDSL lipase 1	MESH:C036216	834101(Tax:3702)	Chemical	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	GDSL_lipase_1 regulates ethylene signaling and ethylene-associated systemic immunity in Arabidopsis .
23043080	0	ethylene	24,32	GREEN-RIPE	46,56	ethylene	GREEN-RIPE	MESH:C036216	778262(Tax:4081)	Chemical	Gene	responses|compound|START_ENTITY responses|nmod|END_ENTITY	Differential control of ethylene responses by GREEN-RIPE and GREEN-RIPE_LIKE1 provides evidence for distinct ethylene signaling modules in tomato .
8612271	0	ethylene	14,22	HOOKLESS1	0,9	ethylene	HOOKLESS1	MESH:C036216	829913(Tax:3702)	Chemical	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	HOOKLESS1 , an ethylene response gene , is required for differential cell elongation in the Arabidopsis hypocotyl .
10810149	0	ethylene	19,27	Pti4	0,4	ethylene	Pti4	MESH:C036216	544041(Tax:4081)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Pti4 is induced by ethylene and salicylic_acid , and its product is phosphorylated by the Pto kinase .
10319818	0	ethylene	95,103	RESPONSIVE-TO-ANTAGONIST1	0,25	ethylene	RESPONSIVE-TO-ANTAGONIST1	MESH:C036216	834509(Tax:3702)	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	RESPONSIVE-TO-ANTAGONIST1 , a Menkes/Wilson _ disease-related_copper transporter , is required for ethylene signaling in Arabidopsis .
15327984	0	ethylene	23,31	TERF1	7,12	ethylene	TERF1	MESH:C036216	606712(Tax:4081)	Chemical	Gene	response|compound|START_ENTITY modulates|dobj|response modulates|nsubj|END_ENTITY	Tomato TERF1 modulates ethylene response and enhances osmotic stress tolerance by activating expression of downstream genes .
11162426	0	ethylene	60,68	calmodulin_binding_protein	2,28	ethylene	calmodulin binding protein	MESH:C036216	817159(Tax:3702)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	A calmodulin_binding_protein from Arabidopsis is induced by ethylene and contains a DNA-binding motif .
16786305	0	ethylene	87,95	cystathionine-gamma-synthase	19,47	ethylene	cystathionine-gamma-synthase	MESH:C036216	543920(Tax:4081)	Chemical	Gene	production|compound|START_ENTITY role|nmod|production role|nmod|END_ENTITY	Regulatory role of cystathionine-gamma-synthase and de novo synthesis of methionine in ethylene production during tomato fruit ripening .
12953109	0	ethylene	70,78	etr1	111,115	ethylene	etr1	MESH:C036216	842951(Tax:3702)	Chemical	Gene	receptors|compound|START_ENTITY mutants|nmod|receptors Analysis|nmod|mutants reveals|nsubj|Analysis reveals|ccomp|has has|nsubj|mutant mutant|amod|END_ENTITY	Analysis of combinatorial loss-of-function mutants in the Arabidopsis ethylene receptors reveals that the ers1 etr1 double mutant has severe developmental_defects that are EIN2 dependent .
17049571	5	ethylene	1132,1140	etr1	1152,1156	ethylene	coi1	MESH:C036216	818581(Tax:3702)	Chemical	Gene	signaling|compound|START_ENTITY signaling|appos|END_ENTITY	A. thaliana lines with mutations in jasmonate -LRB- coi1 -RRB- , salicylate -LRB- npr1 -RRB- , and ethylene signaling -LRB- etr1 -RRB- diverged in gene expression , glucosinolate content , and insect performance compared to wild-type suggesting the involvement of all three modes of signaling in responses to herbivores .
22692214	0	ethylene	0,8	etr1	21,25	ethylene	etr1	MESH:C036216	842951(Tax:3702)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	ethylene receptor 1 -LRB- etr1 -RRB- Is Sufficient and Has the Predominant Role in Mediating Inhibition of Ethylene Responses by Silver in Arabidopsis_thaliana .
10607299	0	ethylene	110,118	pti4	81,85	ethylene	pti4	MESH:C036216	544041(Tax:4081)	Chemical	Gene	independent|nmod|START_ENTITY independent|amod|END_ENTITY	Pseudomonas syringae pv tomato induces the expression of tomato EREBP-like genes pti4 and pti5 independent of ethylene , salicylate and jasmonate The tomato genes Pti4 and Pti5 encode ethylene-responsive element binding protein-like transcription factors that bind to the GCC box , a conserved cis-element in many defense-related genes .
2287839	0	ethylene_glycol	12,27	cytochrome_P-450	50,66	ethylene glycol	cytochrome P-450	MESH:D019855	25251(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Effects of ethylene_glycol on hepatic microsomal cytochrome_P-450 -RSB- .
4024099	0	ethylene_glycol_monomethyl_ether	69,101	CD-1	105,109	ethylene glycol monomethyl ether	CD-1	MESH:C005219	111334(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|compound|END_ENTITY	Developmental phase-specific and dose-related teratogenic effects of ethylene_glycol_monomethyl_ether in CD-1 mice .
3743459	0	ethylene_glycol_monomethyl_ether	90,122	Ornithine_decarboxylase	0,23	ethylene glycol monomethyl ether	Ornithine decarboxylase	MESH:C005219	24609(Tax:10116)	Chemical	Gene	exposure|nmod|START_ENTITY heart|nmod|exposure activity|nmod|heart activity|amod|END_ENTITY	Ornithine_decarboxylase activity in the neonatal rat heart following prenatal exposure to ethylene_glycol_monomethyl_ether .
1362012	0	ethylene_glycol_monomethyl_ether	14,46	gamma-glutamyl_transpeptidase	97,126	ethylene glycol monomethyl ether	gamma-glutamyl transpeptidase	MESH:C005219	116568(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of ethylene_glycol_monomethyl_ether and diethylene_glycol_monomethyl_ether on hepatic gamma-glutamyl_transpeptidase .
20888582	0	ethylenethiourea	106,122	Notch-1	27,34	ethylenethiourea	Notch-1	MESH:D005031	25496(Tax:10116)	Chemical	Gene	analysis|nmod|START_ENTITY analysis|nmod|END_ENTITY	The expression analysis of Notch-1 and Jagged-2 during the development of the hindgut in rat embryos with ethylenethiourea induced anorectal_malformations .
2130946	0	ethylenethiourea	46,62	thyroid_peroxidase	13,31	ethylenethiourea	thyroid peroxidase	MESH:D005031	7173	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|Mechanism Mechanism|nmod|END_ENTITY	Mechanism of thyroid_peroxidase inhibition by ethylenethiourea .
5968071	1	ethylmorphine	87,100	HC1	145,148	ethylmorphine	HC1	MESH:D005036	342358	Chemical	Gene	Kinetics|nmod|START_ENTITY Kinetics|nmod|END_ENTITY	I. Kinetics of the inhibition of the N-demethylation of ethylmorphine by 2-diethylaminoethyl 2,2-diphenylvalerate HC1 -LRB- SKF 525-A -RRB- and related compounds .
6361219	0	ethylnitrosourea	87,103	Glial_fibrillary_acidic_protein	0,31	ethylnitrosourea	Glial fibrillary acidic protein	MESH:D005038	24387(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|END_ENTITY	Glial_fibrillary_acidic_protein -LRB- GFAP -RRB- in rat brain_tumors transplacentally induced by ethylnitrosourea -LRB- ENU -RRB- .
7524194	0	ethylnitrosourea	11,27	pp60c-src	60,69	ethylnitrosourea	pp60c-src	MESH:D005038	83805(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of ethylnitrosourea on expression of proto-oncogene pp60c-src and high-molecular-weight neurofilament protein in rodent embryo central nervous system cells in vitro .
3401885	1	ethynyl	86,93	C-5	121,124	ethynyl	C-5	CHEBI:30085	727	Chemical	Gene	residue|compound|START_ENTITY residue|nmod|END_ENTITY	Synthesis of D-galactose derivatives having an ethynyl , vinyl or epoxy residue at C-5 .
12062934	0	ethynyl_estradiol	74,91	alpha_2u-globulin	17,34	ethynyl estradiol	alpha 2u-globulin	MESH:D004997	298111(Tax:10116)	Chemical	Gene	study|nmod|START_ENTITY END_ENTITY|nmod|study	Changes of serum alpha_2u-globulin in the subacute oral_toxicity study of ethynyl_estradiol and bisphenol_A based on the draft protocol for the ` Enhanced OECD Test Guideline No. 407 ' .
25814138	0	eticlopride	102,113	dopamine_D2_receptor	117,137	eticlopride	dopamine D2 receptor	MESH:C045989	13489(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Erratum to : Behavioral economics of food reinforcement and the effects of prefeeding , extinction , and eticlopride in dopamine_D2_receptor mutant mice .
15232663	0	etizolam	110,118	CYP3A4	100,106	etizolam	CYP3A4	MESH:C044610	1576	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	Inhibition of the metabolism of etizolam by itraconazole in humans : evidence for the involvement of CYP3A4 in etizolam metabolism .
15232663	0	etizolam	32,40	CYP3A4	100,106	etizolam	CYP3A4	MESH:C044610	1576	Chemical	Gene	metabolism|nmod|START_ENTITY Inhibition|nmod|metabolism Inhibition|dep|evidence evidence|nmod|involvement involvement|nmod|END_ENTITY	Inhibition of the metabolism of etizolam by itraconazole in humans : evidence for the involvement of CYP3A4 in etizolam metabolism .
15069535	0	etodolac	22,30	COX-2	44,49	etodolac	COX-2	MESH:D017308	26198(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Inhibitory effects of etodolac , a selective COX-2 inhibitor , on the occurrence of tumors in colitis-induced tumorigenesis model in rats .
12711837	0	etodolac	57,65	cyclooxygenase-2	69,85	etodolac	cyclooxygenase-2	MESH:D017308	29527(Tax:10116)	Chemical	Gene	START_ENTITY|appos|drug drug|amod|END_ENTITY	Anti-inflammatory effect and low ulcerogenic activity of etodolac , a cyclooxygenase-2 selective non-steroidal anti-inflammatory drug , on adjuvant-induced arthritis in rats .
15625783	0	etodolac	63,71	cyclooxygenase-2	35,51	etodolac	cyclooxygenase-2	MESH:D017308	29527(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Suppressive effects of a selective cyclooxygenase-2 inhibitor , etodolac , on 4-nitroquinoline_1-oxide-induced rat tongue carcinogenesis .
17603251	0	etodolac	92,100	cyclooxygenase-2	64,80	etodolac	cyclooxygenase-2	MESH:D017308	5743	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Membranous_nephropathy associated with the relatively selective cyclooxygenase-2 inhibitor , etodolac , in a patient with early rheumatoid_arthritis .
18202786	0	etodolac	54,62	cyclooxygenase-2	26,42	etodolac	cyclooxygenase-2	MESH:D017308	19225(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Inhibitory effects of the cyclooxygenase-2 inhibitor , etodolac , on colitis-associated tumorigenesis in p53-deficient mice treated with dextran sulfate sodium .
19081232	0	etodolac	63,71	cyclooxygenase-2	35,51	etodolac	cyclooxygenase-2	MESH:D017308	29527(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Paradoxical effects of a selective cyclooxygenase-2 inhibitor , etodolac , on proliferative changes of forestomach in alloxan-induced diabetic rats .
15298730	0	etodolac	165,173	cyclooxygenase_2	137,153	etodolac	cyclooxygenase 2	MESH:D017308	5743	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Involvement of cell cycle regulatory proteins and MAP kinase signaling pathway in growth inhibition and cell cycle arrest by a selective cyclooxygenase_2 inhibitor , etodolac , in human hepatocellular_carcinoma cell lines .
6099055	0	etomidate	11,20	ACTH	39,43	etomidate	ACTH	MESH:D005045	5443	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of etomidate and thiopental on ACTH and cortisol levels in serum .
9630337	0	etomidate	44,53	GABA_receptor	85,98	etomidate	GABA receptor	MESH:D005045	11337	Chemical	Gene	sensitivity|amod|START_ENTITY sensitivity|nmod|END_ENTITY	The effect of a transmembrane amino_acid on etomidate sensitivity of an invertebrate GABA_receptor .
21617849	0	etoposide	40,49	Akt	54,57	etoposide	Akt	MESH:D005047	207	Chemical	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	Aspirin reduces the apoptotic effect of etoposide via Akt activation and up-regulation of p21 -LRB- cip -RRB- .
9264562	0	etoposide	24,33	CA-125	43,49	etoposide	CA-125	MESH:D005047	94025	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of low-dose oral etoposide on serum CA-125 in patients with advanced_epithelial_ovarian_cancer .
15528316	0	etoposide	78,87	CD34	105,109	etoposide	CD34	MESH:D005047	947	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Therapy-related acute_myeloid_leukemia-like MLL rearrangements are induced by etoposide in primary human CD34 + cells and remain stable after clonal expansion .
10366432	0	etoposide	81,90	CDK2	16,20	etoposide	CDK2	MESH:D005047	12566(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Dissociation Dissociation|nmod|END_ENTITY	Dissociation of CDK2 from cyclin_A in response to the topoisomerase II inhibitor etoposide in v-src-transformed but not normal NIH 3T3 cells .
2241183	0	etoposide	31,40	EAP	57,60	etoposide	EAP	MESH:D005047	2028	Chemical	Gene	Combination|nmod|START_ENTITY Combination|appos|END_ENTITY	-LSB- Combination chemotherapy with etoposide , ADM , and CDDP -LRB- EAP -RRB- for advanced gastric_cancer -RSB- .
8265093	0	etoposide	60,69	EAP	97,100	etoposide	EAP	MESH:D005047	2028	Chemical	Gene	combination|nmod|START_ENTITY combination|appos|END_ENTITY	Treatment of gastric_adenocarcinoma with the combination of etoposide , adriamycin and cisplatin -LRB- EAP -RRB- : comparison between two schedules .
23433111	0	etoposide	55,64	Egr-1	0,5	etoposide	Egr-1	MESH:D005047	1958	Chemical	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Egr-1 regulates the transcription of the BRCA1 gene by etoposide .
26232556	0	etoposide	52,61	Erythropoietin	0,14	etoposide	Erythropoietin	MESH:D005047	2056	Chemical	Gene	protects|nmod|START_ENTITY protects|nsubj|END_ENTITY	Erythropoietin protects neuroblastoma cells against etoposide and vincristine by activating ERK and AKT pathways but has no effect in kidney cells .
14630082	0	etoposide	73,82	NF-kappaB	13,22	etoposide	NF-kappaB	MESH:D005047	4790	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Dual role of NF-kappaB in apoptosis of THP-1 cells during treatment with etoposide and lipopolysaccharide .
24882643	0	etoposide	40,49	P-glycoprotein	82,96	etoposide	P-glycoprotein	MESH:D005047	5243	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of repeated oral treatment with etoposide on the expression of intestinal P-glycoprotein and oral morphine analgesia -RSB- .
15223313	0	etoposide	77,86	PKC_delta	134,143	etoposide	PKC delta	MESH:D005047	18753(Tax:10090)	Chemical	Gene	gene|nmod|START_ENTITY regulation|nmod|gene regulation|dep|implication implication|nmod|autoregulation autoregulation|compound|END_ENTITY	Transcriptional and post-transcriptional regulation of the PKC_delta gene by etoposide in L1210 murine leukemia cells : implication of PKC_delta autoregulation .
15223313	0	etoposide	77,86	PKC_delta	59,68	etoposide	PKC delta	MESH:D005047	18753(Tax:10090)	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Transcriptional and post-transcriptional regulation of the PKC_delta gene by etoposide in L1210 murine leukemia cells : implication of PKC_delta autoregulation .
10898537	0	etoposide	27,36	VP-16	38,43	etoposide	VP-16	MESH:D005047	3054	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY pharmacokinetics|appos|END_ENTITY	Plasma pharmacokinetics of etoposide -LRB- VP-16 -RRB- after i.v. administration to children .
1920837	0	etoposide	34,43	VP-16	45,50	etoposide	VP-16	MESH:D005047	3054	Chemical	Gene	administration|nmod|START_ENTITY administration|appos|END_ENTITY	-LSB- Long-term oral administration of etoposide -LRB- VP-16 -RRB- for the patients with refractory or relapsed acute_non-lymphocytic_leukemia -RSB- .
1991703	0	etoposide	12,21	VP-16	23,28	etoposide	VP-16	MESH:D005047	3054	Chemical	Gene	Activity|nmod|START_ENTITY Activity|appos|END_ENTITY	Activity of etoposide -LRB- VP-16 -RRB- in human tumor cells under different growth conditions .
2226679	0	etoposide	14,23	VP-16	25,30	etoposide	VP-16	MESH:D005047	3054	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|appos|END_ENTITY	Modulation of etoposide -LRB- VP-16 -RRB- cytotoxicity by verapamil or cyclosporine in multidrug-resistant human leukemic cell lines and normal bone marrow .
2262732	0	etoposide	11,20	VP-16	22,27	etoposide	VP-16	MESH:D005047	3054	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of etoposide -LRB- VP-16 -RRB- on the survival and progression of cultured HeLa S3 cells through the cell cycle .
3410665	0	etoposide	18,27	VP-16	29,34	etoposide	VP-16	MESH:D005047	3054	Chemical	Gene	trial|nmod|START_ENTITY trial|appos|END_ENTITY	Clinical trial of etoposide -LRB- VP-16 -RRB- in children with recurrent malignant_solid_tumors .
4015122	0	etoposide	19,28	VP-16	30,35	etoposide	VP-16	MESH:D005047	3054	Chemical	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	-LSB- Phase II study of etoposide -LRB- VP-16 -RRB- in the form of oral capsules for malignant_lymphomas -RSB- .
4061373	0	etoposide	18,27	VP-16	29,34	etoposide	VP-16	MESH:D005047	3054	Chemical	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Phase II study of etoposide -LRB- VP-16 -RRB- in the treatment of advanced head_and_neck_cancer .
7789893	0	etoposide	50,59	VP-16	61,66	etoposide	VP-16	MESH:D005047	3054	Chemical	Gene	treatment|compound|START_ENTITY treatment|compound|END_ENTITY	Carboplatin -LRB- CBDCA -RRB- - hexamethylmelamine -LRB- HMM -RRB- - oral etoposide -LRB- VP-16 -RRB- first-line treatment of ovarian_cancer patients with bulky disease : a phase II study .
8551665	0	etoposide	27,36	VP-16	38,43	etoposide	VP-16	MESH:D005047	3054	Chemical	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	An early phase II study of etoposide -LRB- VP-16 -RRB- in advanced gastric_cancer .
1785427	0	etoposide	17,26	VP16	28,32	etoposide	VP16	MESH:D005047	3054	Chemical	Gene	activity|nmod|START_ENTITY activity|appos|END_ENTITY	-LSB- The activity of etoposide -LRB- VP16 -RRB- in combination chemotherapy against human bladder_cancer cells in vitro -RSB- .
6539169	0	etoposide	20,29	VP16	31,35	etoposide	VP16	MESH:D005047	3054	Chemical	Gene	Pharmacokinetics|nmod|START_ENTITY Pharmacokinetics|appos|END_ENTITY	Pharmacokinetics of etoposide -LRB- VP16 -RRB- in children and adolescents with refractory solid_tumors .
26628978	0	etoposide	54,63	WNT1-inducible-signaling_pathway_protein_1	8,50	etoposide	WNT1-inducible-signaling pathway protein 1	MESH:D005047	8840	Chemical	Gene	resistance|amod|START_ENTITY END_ENTITY|nmod|resistance	Role of WNT1-inducible-signaling_pathway_protein_1 in etoposide resistance in lung_adenocarcinoma A549 cells .
22615609	0	etoposide	55,64	WWOX	8,12	etoposide	WWOX	MESH:D005047	51741	Chemical	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Primary WWOX phosphorylation and JNK activation during etoposide induces cytotoxicity in HEK293 cells .
10318846	0	etoposide	86,95	caspase-8	132,141	etoposide	caspase-8	MESH:D005047	841	Chemical	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Common regulation of apoptosis signaling induced by CD95 and the DNA-damaging stimuli etoposide and gamma-radiation downstream from caspase-8 activation .
14646514	0	etoposide	21,30	caspase-8	42,51	etoposide	caspase-8	MESH:D005047	841	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|processing processing|amod|END_ENTITY	The anti-cancer drug etoposide can induce caspase-8 processing and apoptosis in the absence of CD95 receptor-ligand interaction .
8913519	0	etoposide	43,52	deoxycytidine_kinase	10,30	etoposide	deoxycytidine kinase	MESH:D005047	13178(Tax:10090)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Increased deoxycytidine_kinase activity by etoposide in L1210 murine leukemic cells .
17092291	0	etoposide	110,119	epidermal_growth_factor_receptor	18,50	etoposide	epidermal growth factor receptor	MESH:D005047	1956	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of the epidermal_growth_factor_receptor in bladder_cancer cells treated with the DNA-damaging drug etoposide markedly increases apoptosis .
8261405	0	etoposide	43,52	granulocyte-macrophage_colony-stimulating_factor	69,117	etoposide	granulocyte-macrophage colony-stimulating factor	MESH:D005047	1437	Chemical	Gene	trial|nmod|START_ENTITY I|dobj|trial I|nmod|END_ENTITY	A randomized phase I trial of chronic oral etoposide with or without granulocyte-macrophage_colony-stimulating_factor in patients with advanced malignancies .
18256325	0	etoposide	24,33	interleukin-2	153,166	etoposide	interleukin-2	MESH:D005047	3558	Chemical	Gene	transplantation|amod|START_ENTITY irradiation|appos|transplantation followed|nsubj|irradiation followed|nmod|END_ENTITY	Total body irradiation , etoposide , cyclophosphamide , and autologous peripheral blood stem-cell transplantation followed by randomization to therapy with interleukin-2 versus observation for patients with non-Hodgkin_lymphoma : results of a phase 3 randomized trial by the Southwest Oncology Group -LRB- SWOG 9438 -RRB- .
14695654	0	etoposide	16,25	interleukin_3	80,93	etoposide	interleukin 3	MESH:D005047	16187(Tax:10090)	Chemical	Gene	action|nmod|START_ENTITY action|nmod|END_ENTITY	Toxic action of etoposide on mouse peritoneal macrophages and its modulation by interleukin_3 .
25395162	0	etoposide	50,59	multidrug_resistance_1	77,99	etoposide	multidrug resistance 1	MESH:D005047	5243	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Upregulation of Stat1-HDAC4 confers resistance to etoposide through enhanced multidrug_resistance_1 expression in human A549_lung_cancer cells .
11820594	0	etoposide	135,144	p21	14,17	etoposide	p21	MESH:D005047	644914	Chemical	Gene	chemotherapy|compound|START_ENTITY resected|nmod|chemotherapy resected|nsubj|Expression Expression|nmod|proteins proteins|amod|END_ENTITY	Expression of p21 and bcl-2 proteins and p53 mRNA in surgically resected preparations of non-small_cell_lung_cancer -LRB- stage IIIA -RRB- after etoposide and cisplatin chemotherapy .
21617849	0	etoposide	40,49	p21	90,93	etoposide	p21	MESH:D005047	644914	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Aspirin reduces the apoptotic effect of etoposide via Akt activation and up-regulation of p21 -LRB- cip -RRB- .
9106647	0	etoposide	14,23	small-cell_lung_cancer	47,69	etoposide	small-cell lung cancer	MESH:D005047	7864	Chemical	Gene	treatment|compound|START_ENTITY treatment|nmod|END_ENTITY	Five-day oral etoposide treatment for advanced small-cell_lung_cancer : randomized comparison with intravenous chemotherapy .
11915179	0	etoposide	55,64	vimentin	18,26	etoposide	vimentin	MESH:D005047	7431	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|expression expression|nmod|END_ENTITY	The expression of vimentin in HL-60 cells induced with etoposide using immunofluorescence and immunogold methods .
12817520	0	etoricoxib	20,30	COX-2	51,56	etoricoxib	COX-2	MESH:C422649	4513	Chemical	Gene	Characterization|nmod|START_ENTITY Characterization|appos|inhibitor inhibitor|compound|END_ENTITY	Characterization of etoricoxib , a novel , selective COX-2 inhibitor .
12907325	0	etoricoxib	61,71	COX-2	35,40	etoricoxib	COX-2	MESH:C422649	4513	Chemical	Gene	START_ENTITY|amod|selective selective|amod|END_ENTITY	The gastrointestinal safety of the COX-2 selective inhibitor etoricoxib assessed by both endoscopy and analysis of upper gastrointestinal events .
16598848	0	etoricoxib	58,68	COX-2	41,46	etoricoxib	COX-2	MESH:C422649	4513	Chemical	Gene	inhibitors|xcomp|START_ENTITY inhibitors|nsubj|effects effects|nmod|END_ENTITY	Different COX-independent effects of the COX-2 inhibitors etoricoxib and lumiracoxib .
17265571	0	etoricoxib	104,114	COX-2	78,83	etoricoxib	COX-2	MESH:C422649	4513	Chemical	Gene	START_ENTITY|amod|selective selective|amod|END_ENTITY	Pooled analysis of thrombotic_cardiovascular events in clinical trials of the COX-2 selective Inhibitor etoricoxib .
18171381	0	etoricoxib	47,57	COX-2	71,76	etoricoxib	COX-2	MESH:C422649	4513	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Primary stabbing headache can be responsive to etoricoxib , a selective COX-2 inhibitor .
19589894	0	etoricoxib	140,150	COX-2	18,23	etoricoxib	COX-2	MESH:C422649	4513	Chemical	Gene	comparing|dobj|START_ENTITY trials|acl|comparing results|nmod|trials response|dep|results response|nmod|inhibitors inhibitors|compound|END_ENTITY	Early response to COX-2 inhibitors as a predictor of overall response in osteoarthritis : pooled results from two identical trials comparing etoricoxib , celecoxib and placebo .
21198287	0	etoricoxib	44,54	COX-2	68,73	etoricoxib	COX-2	MESH:C422649	26198(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Anti-proliferative and apoptotic effects of etoricoxib , a selective COX-2 inhibitor , on 1,2-dimethylhydrazine _ dihydrochloride-induced colon_carcinogenesis .
21441618	0	etoricoxib	101,111	COX-2	125,130	etoricoxib	COX-2	MESH:C422649	19225(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Heme oxygenase/carbon _ monoxide-biliverdin pathway may be involved in the antinociceptive activity of etoricoxib , a selective COX-2 inhibitor .
22991065	0	etoricoxib	106,116	COX-2	79,84	etoricoxib	COX-2	MESH:C422649	26198(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Role of cytokines in experimentally induced lung_cancer and chemoprevention by COX-2 selective inhibitor , etoricoxib .
25701797	0	etoricoxib	59,69	COX-2	43,48	etoricoxib	COX-2	MESH:C422649	26198(Tax:10116)	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|END_ENTITY	Antiepileptogenic effects of the selective COX-2 inhibitor etoricoxib , on the development of spontaneous absence_seizures in WAG/Rij rats .
27007068	0	etoricoxib	42,52	COX-2	54,59	etoricoxib	COX-2	MESH:C422649	4513	Chemical	Gene	action|nmod|START_ENTITY mode|nmod|action Evidence|nmod|mode Evidence|appos|Inhibitor Inhibitor|compound|END_ENTITY	Evidence for a central mode of action for etoricoxib -LRB- COX-2 Inhibitor -RRB- in patients with painful_knee_osteoarthritis .
19105535	0	etoricoxib	31,41	Cyclooxygenase-2	0,16	etoricoxib	Cyclooxygenase-2	MESH:C422649	29527(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Cyclooxygenase-2 inhibition by etoricoxib modulates plasma membrane fluidity in rat colon .
22681911	0	etoricoxib	61,71	MK0663	73,79	etoricoxib	MK0663	MESH:C422649	1476764(Tax:190192)	Chemical	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Angiostatic role of the selective cyclooxygenase-2 inhibitor etoricoxib -LRB- MK0663 -RRB- in experimental lung_cancer .
16454836	0	etoricoxib	62,72	cox-2	86,91	etoricoxib	cox-2	MESH:C422649	4513	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	The gastrointestinal safety and effect on disease activity of etoricoxib , a selective cox-2 inhibitor in inflammatory_bowel_diseases .
11353749	0	etoricoxib	59,69	cyclooxygenase-2	79,95	etoricoxib	cyclooxygenase-2	MESH:C422649	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Role of human liver cytochrome P4503A in the metabolism of etoricoxib , a novel cyclooxygenase-2 selective inhibitor .
11583479	0	etoricoxib	29,39	cyclooxygenase-2	60,76	etoricoxib	cyclooxygenase-2	MESH:C422649	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Dose proportionality of oral etoricoxib , a highly selective cyclooxygenase-2 inhibitor , in healthy volunteers .
11835200	0	etoricoxib	62,72	cyclooxygenase-2	80,96	etoricoxib	cyclooxygenase-2	MESH:C422649	5743	Chemical	Gene	determination|nmod|START_ENTITY determination|appos|inhibitor inhibitor|amod|END_ENTITY	Simultaneous determination of unlabeled and carbon-13-labeled etoricoxib , a new cyclooxygenase-2 inhibitor , in human plasma using HPLC-MS/MS .
12527704	0	etoricoxib	41,51	cyclooxygenase-2	76,92	etoricoxib	cyclooxygenase-2	MESH:C422649	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Absorption , metabolism , and excretion of etoricoxib , a potent and selective cyclooxygenase-2 inhibitor , in healthy male volunteers .
12638395	0	etoricoxib	46,56	cyclooxygenase-2	83,99	etoricoxib	cyclooxygenase-2	MESH:C422649	5743	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY pharmacokinetics|appos|inhibitor inhibitor|nmod|END_ENTITY	Single - and multiple-dose pharmacokinetics of etoricoxib , a selective inhibitor of cyclooxygenase-2 , in man .
15853965	0	etoricoxib	22,32	cyclooxygenase-2	59,75	etoricoxib	cyclooxygenase-2	MESH:C422649	29527(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|inhibitor inhibitor|nmod|END_ENTITY	Protective effects of etoricoxib , a selective inhibitor of cyclooxygenase-2 , in experimental periodontitis in rats .
16892790	0	etoricoxib	10,20	cyclooxygenase-2	33,49	etoricoxib	cyclooxygenase-2	MESH:C422649	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Safety of etoricoxib , a specific cyclooxygenase-2 inhibitor , in asthmatic patients with aspirin-exacerbated_respiratory_disease .
16136765	0	etoricoxib	10,20	cyclooxygenase_2	28,44	etoricoxib	cyclooxygenase 2	MESH:C422649	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Safety of etoricoxib , a new cyclooxygenase_2 inhibitor , in patients with nonsteroidal anti-inflammatory drug-induced urticaria and angioedema .
21457143	0	etoricoxib	58,68	organic_anion_transporter_3	78,105	etoricoxib	organic anion transporter 3	MESH:C422649	9376	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Inhibitory effect of selective cyclooxygenase-2 inhibitor etoricoxib on human organic_anion_transporter_3 -LRB- hOAT3 -RRB- .
7962965	0	etretinate	11,21	IL-1_alpha	90,100	etretinate	IL-1 alpha	MESH:D005050	3552	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of etretinate on keratinocyte proliferation and secretion of interleukin-1_alpha -LRB- IL-1_alpha -RRB- and IL-8 .
17506951	0	eucalyptol	33,43	Egr-1	48,53	eucalyptol	Egr-1	MESH:C010087	1958	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Inhibitory effect of 1,8-cineol -LRB- eucalyptol -RRB- on Egr-1 expression in lipopolysaccharide-stimulated THP-1 cells .
16972787	7	eugenol	1289,1296	AhR	1358,1361	eugenol	AhR	MESH:D005054	196	Chemical	Gene	effects|nmod|START_ENTITY mediated|nsubjpass|effects mediated|nmod|END_ENTITY	In summary , these results , together with our previous findings that both compounds induce translocation of the AhR into the nucleus , provide good evidence that the effects of eugenol and isoeugenol in skin and keratinocytes are mediated by the AhR .
10930724	0	eugenol	21,28	PAF	32,35	eugenol	PAF	MESH:D005054	9768	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Preventive effect of eugenol on PAF and ethanol-induced gastric_mucosal_damage .
24144396	0	eugenol	18,25	UDP-glucuronosyltransferase	68,95	eugenol	UDP-glucuronosyltransferase	MESH:D005054	24862(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of dietary eugenol on xenobiotic metabolism and mediation of UDP-glucuronosyltransferase and cytochrome_P450_1A1 expression in rat liver .
24384226	0	eugenol	56,63	transient_receptor_potential_ankyrin_1	14,52	eugenol	transient receptor potential ankyrin 1	MESH:D005054	8989	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of transient_receptor_potential_ankyrin_1 by eugenol .
14514756	0	eugenol	44,51	vanilloid_receptor_1	14,34	eugenol	vanilloid receptor 1	MESH:D005054	7442	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of vanilloid_receptor_1 -LRB- VR1 -RRB- by eugenol .
17637181	5	eugenosedin-A	881,894	rats	875,879	eugenosedin-A	iNOS	MESH:C496985	24599(Tax:10116)	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|nmod|END_ENTITY	In the pre-treated rats , eugenosedin-A not only inhibited the LPS-induced NO and PGE -LRB- 2 -RRB- levels but also attenuated the LPS-induced increase in p38 MAPK and iNOS levels in the liver , aorta and lymphocytes .
19601638	0	eupatorin	26,35	CYP1	57,61	eupatorin	CYP1	MESH:C103110	1543	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	The methoxylated flavones eupatorin and cirsiliol induce CYP1 enzyme expression in MCF7 cells .
23881640	0	eurycomanone	10,22	CYP1A2	51,57	eurycomanone	CYP1A2	MESH:C506425	1544	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of eurycomanone on cytochrome_P450 isoforms CYP1A2 , CYP2A6 , CYP2C8 , CYP2C9 , CYP2C19 , CYP2E1 and CYP3A4 in vitro .
26264702	0	evacetrapib	41,52	CETP	73,77	evacetrapib	CETP	MESH:C568301	1071	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	CYP-mediated drug-drug interactions with evacetrapib , an investigational CETP inhibitor : in vitro prediction and clinical outcome .
24961753	0	evacetrapib	60,71	cholesteryl_ester_transfer_protein	15,49	evacetrapib	cholesteryl ester transfer protein	MESH:C568301	1071	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|Effects Effects|nmod|END_ENTITY	Effects of the cholesteryl_ester_transfer_protein inhibitor evacetrapib on lipoproteins , apolipoproteins and 24-h ambulatory blood pressure in healthy adults .
21994954	0	everolimus	109,119	Chromogranin_A	0,14	everolimus	Chromogranin A	MESH:C107135	1113	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|END_ENTITY	Chromogranin_A and neuron-specific_enolase as prognostic markers in patients with advanced pNET treated with everolimus .
23153318	0	everolimus	26,36	HER2	136,140	everolimus	HER2	MESH:C107135	2064	Chemical	Gene	START_ENTITY|nmod|treatment treatment|nmod|receptor receptor|appos|- -|compound|END_ENTITY	Budget impact analysis of everolimus for the treatment of hormone receptor positive , human epidermal_growth_factor_receptor-2 negative -LRB- HER2 - -RRB- advanced breast_cancer in the United States .
23962028	0	everolimus	132,142	HER2	88,92	everolimus	HER2	MESH:C107135	2064	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|END_ENTITY	Health-related quality of life and disease symptoms in postmenopausal women with HR -LRB- + -RRB- , HER2 -LRB- - -RRB- advanced_breast_cancer treated with everolimus plus exemestane versus exemestane monotherapy .
25415641	0	everolimus	26,36	HER2	136,140	everolimus	HER2	MESH:C107135	2064	Chemical	Gene	START_ENTITY|nmod|treatment treatment|nmod|receptor receptor|appos|- -|compound|END_ENTITY	Budget impact analysis of everolimus for the treatment of hormone receptor positive , human_epidermal_growth_factor_receptor-2 negative -LRB- HER2 - -RRB- advanced breast_cancer in Kazakhstan .
26387602	0	everolimus	26,36	HER2	78,82	everolimus	HER2	MESH:C107135	2064	Chemical	Gene	START_ENTITY|nmod|patients patients|compound|END_ENTITY	Efficacy and tolerance of everolimus in 123 consecutive advanced ER positive , HER2 negative breast_cancer patients .
26387602	0	everolimus	26,36	HER2	78,82	everolimus	HER2	MESH:C107135	2064	Chemical	Gene	START_ENTITY|nmod|patients patients|compound|END_ENTITY	Efficacy and tolerance of everolimus in 123 consecutive advanced ER positive , HER2 negative breast_cancer patients .
26651842	0	everolimus	21,31	HER2	85,89	everolimus	HER2	MESH:C107135	2064	Chemical	Gene	Time|nmod|START_ENTITY Time|parataxis|END_ENTITY	Time on treatment of everolimus and chemotherapy among postmenopausal women with HR + / HER2 - metastatic breast_cancer : A retrospective claims study in the US .
27052735	0	everolimus	58,68	HER2	106,110	everolimus	HER2	MESH:C107135	2064	Chemical	Gene	use|nmod|START_ENTITY associated|nmod|use associated|nmod|END_ENTITY	Treatment patterns and factors associated with the use of everolimus among post-menopausal women with HR + / HER2 - metastatic breast_cancer : a retrospective US claims study .
17980369	0	everolimus	52,62	LDLR	66,70	everolimus	LDLR	MESH:C107135	16835(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Prevention of atherosclerosis by the mTOR inhibitor everolimus in LDLR - / - mice despite severe hypercholesterolemia .
19509067	0	everolimus	63,73	Mammalian_target_of_rapamycin	0,29	everolimus	Mammalian target of rapamycin	MESH:C107135	2475	Chemical	Gene	rapamycin|appos|START_ENTITY induce|nsubj|rapamycin inhibitors|ccomp|induce inhibitors|nsubj|END_ENTITY	Mammalian_target_of_rapamycin inhibitors rapamycin and RAD001 -LRB- everolimus -RRB- induce anti-proliferative effects in GH-secreting pituitary_tumor cells in vitro .
21697773	0	everolimus	91,101	calcineurin_inhibitor	58,79	everolimus	calcineurin inhibitor	MESH:C107135	23523	Chemical	Gene	therapy|nmod|START_ENTITY therapy|compound|END_ENTITY	Conversion of long-term kidney transplant recipients from calcineurin_inhibitor therapy to everolimus : a randomized , multicenter , 24-month study .
25512099	0	everolimus	130,140	calcineurin_inhibitor	97,118	everolimus	calcineurin inhibitor	MESH:C107135	23523	Chemical	Gene	therapy|nmod|START_ENTITY therapy|compound|END_ENTITY	Renal , efficacy and safety outcomes following late conversion of kidney transplant patients from calcineurin_inhibitor therapy to everolimus : the randomized APOLLO study .
25604795	0	everolimus	57,67	estrogen_receptor	96,113	everolimus	estrogen receptor	MESH:C107135	2099	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	Erratum to : A phase II study of combined fulvestrant and everolimus in patients with metastatic estrogen_receptor -LRB- ER -RRB- - positive breast_cancer after aromatase inhibitor -LRB- AI -RRB- failure .
17310129	0	everolimus	33,43	mTOR	10,14	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	RAD001|appos|START_ENTITY RAD001|compound|END_ENTITY	The novel mTOR inhibitor RAD001 -LRB- everolimus -RRB- induces antiproliferative effects in human pancreatic_neuroendocrine_tumor cells .
17980369	0	everolimus	52,62	mTOR	37,41	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Prevention Prevention|nmod|atherosclerosis atherosclerosis|nmod|inhibitor inhibitor|compound|END_ENTITY	Prevention of atherosclerosis by the mTOR inhibitor everolimus in LDLR - / - mice despite severe hypercholesterolemia .
18039566	0	everolimus	32,42	mTOR	9,13	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	RAD001|appos|START_ENTITY RAD001|compound|END_ENTITY	The oral mTOR inhibitor RAD001 -LRB- everolimus -RRB- in combination with letrozole in patients with advanced breast_cancer : results of a phase I study with pharmacokinetics .
18319715	0	everolimus	30,40	mTOR	14,18	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	pathway|nmod|START_ENTITY pathway|compound|END_ENTITY	Inhibition of mTOR pathway by everolimus cooperates with EGFR inhibitors in human tumours sensitive and resistant to anti-EGFR drugs .
19047305	0	everolimus	20,30	mTOR	5,9	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|inhibitor inhibitor|compound|END_ENTITY	Oral mTOR inhibitor everolimus in patients with gemcitabine-refractory metastatic pancreatic_cancer .
19223496	0	everolimus	23,33	mTOR	0,4	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	RAD001|appos|START_ENTITY RAD001|compound|END_ENTITY	mTOR inhibitor RAD001 -LRB- everolimus -RRB- has antiangiogenic/vascular properties distinct from a VEGFR tyrosine kinase inhibitor .
19306412	0	everolimus	72,82	mTOR	49,53	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	RAD001|dobj|START_ENTITY RAD001|nsubj|study study|nmod|regimen regimen|nmod|inhibitor inhibitor|compound|END_ENTITY	A phase 2 study with a daily regimen of the oral mTOR inhibitor RAD001 -LRB- everolimus -RRB- in patients with metastatic clear_cell_renal_cell_cancer .
19471857	0	everolimus	39,49	mTOR	16,20	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	activity|appos|START_ENTITY activity|nmod|RAD001 RAD001|compound|END_ENTITY	The activity of mTOR inhibitor RAD001 -LRB- everolimus -RRB- in nasopharyngeal_carcinoma and cisplatin-resistant cell lines .
19513966	0	everolimus	41,51	mTOR	18,22	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	Role|appos|START_ENTITY Role|nmod|RAD001 RAD001|compound|END_ENTITY	Role of the novel mTOR inhibitor RAD001 -LRB- everolimus -RRB- in anaplastic_thyroid_cancer .
19837761	0	everolimus	142,152	mTOR	127,131	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	START_ENTITY|amod|non-small_cell_lung_cancer non-small_cell_lung_cancer|nmod|END_ENTITY	Downregulation of 18F-FDG uptake in PET as an early pharmacodynamic effect in treatment of non-small_cell_lung_cancer with the mTOR inhibitor everolimus .
20005385	0	everolimus	75,85	mTOR	59,63	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Immunosuppression Immunosuppression|acl|using using|dobj|inhibitor inhibitor|appos|END_ENTITY	Immunosuppression using the mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitor everolimus : pilot study shows significant cognitive and affective improvement .
20014066	0	everolimus	9,19	mTOR	30,34	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	RAD_001|dep|START_ENTITY prevents|nsubj|RAD_001 prevents|dobj|re-activation re-activation|amod|END_ENTITY	RAD_001 -LRB- everolimus -RRB- prevents mTOR and Akt late re-activation in response to imatinib in chronic_myeloid_leukemia .
20229590	0	everolimus	44,54	mTOR	29,33	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|trial trial|nmod|inhibitor inhibitor|compound|END_ENTITY	A Phase II trial of the oral mTOR inhibitor everolimus in relapsed Hodgkin_lymphoma .
20471160	0	everolimus	19,29	mTOR	0,4	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	mTOR inhibition by everolimus counteracts VEGF induction by sunitinib and improves anti-tumor activity against gastric_cancer in vivo .
20847160	0	everolimus	77,87	mTOR	58,62	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	efficacy|nmod|START_ENTITY efficacy|nmod|inhibition inhibition|compound|END_ENTITY	18F-FLT PET as a surrogate marker of drug efficacy during mTOR inhibition by everolimus in a preclinical cisplatin-resistant ovarian_tumor model .
20890178	0	everolimus	34,44	mTOR	18,22	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Evaluation Evaluation|nmod|inhibitor inhibitor|compound|END_ENTITY	Evaluation of the mTOR inhibitor , everolimus , in combination with cytotoxic antitumor agents using human tumor models in vitro and in vivo .
20960030	0	everolimus	94,104	mTOR	79,83	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|inhibition inhibition|nmod|cells cells|nmod|cotreatment cotreatment|nmod|END_ENTITY	Schedule-dependent inhibition of T-cell_lymphoma cells by cotreatment with the mTOR inhibitor everolimus and anticancer drugs .
20970607	0	everolimus	80,90	mTOR	63,67	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	analysis|dep|START_ENTITY analysis|nmod|events events|acl|requiring requiring|dobj|suspension suspension|nmod|inhibitors inhibitors|compound|END_ENTITY	Comparative analysis of adverse events requiring suspension of mTOR inhibitors : everolimus versus sirolimus .
21107682	0	everolimus	37,47	mTOR	22,26	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|trial trial|nmod|inhibitor inhibitor|compound|END_ENTITY	Phase I trial of oral mTOR inhibitor everolimus in combination with trastuzumab and vinorelbine in pre-treated patients with HER2-overexpressing metastatic breast_cancer .
21135857	0	everolimus	44,54	mTOR	29,33	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|trial trial|nmod|inhibitor inhibitor|compound|END_ENTITY	A phase II trial of the oral mTOR inhibitor everolimus in relapsed aggressive_lymphoma .
21177764	0	everolimus	57,67	mTOR	12,16	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	trial|nmod|START_ENTITY END_ENTITY|dep|trial	Combination mTOR and IGF-1R inhibition : phase I trial of everolimus and figitumumab in patients with advanced sarcomas and other solid_tumors .
21725052	0	everolimus	23,33	mTOR	37,41	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Safety and efficacy of everolimus , a mTOR inhibitor , as single agent in a phase 1/2 study in patients with myelofibrosis .
22214465	0	everolimus	20,30	mTOR	0,4	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	target|nmod|START_ENTITY END_ENTITY|nmod|target	mTOR as a target of everolimus in refractory/relapsed Hodgkin_lymphoma .
22333597	0	everolimus	66,76	mTOR	27,31	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|pathway pathway|compound|END_ENTITY	Aberrant activation of the mTOR pathway and anti-tumour effect of everolimus on oesophageal_squamous_cell_carcinoma .
22427849	0	everolimus	41,51	mTOR	8,12	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	dose|nmod|START_ENTITY inhibition|nmod|dose inhibition|compound|END_ENTITY	Delayed mTOR inhibition with low dose of everolimus reduces TGFb expression , attenuates proteinuria and renal_damage in the renal mass reduction model .
22492237	0	everolimus	39,49	mTOR	24,28	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|inhibitor inhibitor|compound|END_ENTITY	Antitumor effect of the mTOR inhibitor everolimus in combination with trastuzumab on human breast_cancer stem cells in vitro and in vivo .
22703543	0	everolimus	12,22	mTOR	32,36	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Efficacy of everolimus , a novel mTOR inhibitor , against basal-like triple-negative breast_cancer cells .
22751858	0	everolimus	143,153	mTOR	128,132	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Remission Remission|nmod|Kaposi_sarcoma Kaposi_sarcoma|nmod|patient patient|nmod|myasthenia_gravis myasthenia_gravis|acl|switching switching|nmod|inhibitor inhibitor|compound|END_ENTITY	-LSB- Remission of an iatrogenic Kaposi_sarcoma in a patient with myasthenia_gravis after switching immunosuppressive therapy to the mTOR inhibitor everolimus -RSB- .
22829152	0	everolimus	20,30	mTOR	4,8	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	The mTOR inhibitor , everolimus -LRB- RAD001 -RRB- , overcomes resistance to imatinib in quiescent Ph-positive acute_lymphoblastic_leukemia cells .
22843927	0	everolimus	19,29	mTOR	4,8	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|inhibitor inhibitor|compound|END_ENTITY	The mTOR inhibitor everolimus in combination with carboplatin in metastatic breast_cancer -- a phase I trial .
22943457	0	everolimus	45,55	mTOR	30,34	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|treatment treatment|nmod|inhibitor inhibitor|compound|END_ENTITY	Successful treatment with the mTOR inhibitor everolimus in a patient with perivascular_epithelioid_cell_tumor .
23022334	0	everolimus	78,88	mTOR	63,67	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Involvement Involvement|nmod|autophagy autophagy|nmod|effects effects|nmod|inhibitor inhibitor|compound|END_ENTITY	Involvement of autophagy in the pharmacological effects of the mTOR inhibitor everolimus in acute kidney_injury .
23408390	4	everolimus	578,588	mTOR	714,718	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	inhibitors|nmod|START_ENTITY evaluated|nsubjpass|inhibitors evaluated|advcl|limited limited|nmod|lack lack|nmod|inhibition inhibition|compound|END_ENTITY	mTOR inhibitors such as everolimus have been evaluated as adjunctive chemotherapy with some success , although efficacy has been limited by the lack of complete mTOR pathway inhibition .
23426850	0	everolimus	23,33	mTOR	0,4	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	RAD001|appos|START_ENTITY RAD001|compound|END_ENTITY	mTOR inhibitor RAD001 -LRB- everolimus -RRB- induces apoptotic , not autophagic cell death , in human nasopharyngeal_carcinoma cells .
23659703	0	everolimus	15,25	mTOR	40,44	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Development of everolimus , a novel oral mTOR inhibitor , across a spectrum of diseases .
23785409	0	everolimus	71,81	mTOR	55,59	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	inhibitors|dobj|START_ENTITY inhibitors|nsubj|Incidence Incidence|nmod|mortality mortality|nmod|END_ENTITY	Incidence and risk of treatment-related mortality with mTOR inhibitors everolimus and temsirolimus in cancer patients : a meta-analysis .
23838481	0	everolimus	69,79	mTOR	47,51	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|effects effects|appos|END_ENTITY	Bone effects of mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibition with everolimus .
24625776	0	everolimus	92,102	mTOR	11,15	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	trial|nmod|START_ENTITY mutations|nmod|trial mutations|compound|END_ENTITY	Activating mTOR mutations in a patient with an extraordinary response on a phase I trial of everolimus and pazopanib .
24716234	0	everolimus	67,77	mTOR	52,56	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|results results|nmod|trial trial|nmod|END_ENTITY	Long-term results of the phase II trial of the oral mTOR inhibitor everolimus -LRB- RAD001 -RRB- in relapsed or refractory Waldenstrom_Macroglobulinemia .
24886512	0	everolimus	58,68	mTOR	19,23	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	efficacy|nmod|START_ENTITY predicts|dobj|efficacy predicts|nsubj|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation of mTOR and S6RP predicts the efficacy of everolimus in patients with metastatic_renal_cell_carcinoma .
24903015	0	everolimus	24,34	mTOR	14,18	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	growth|nmod|START_ENTITY growth|compound|END_ENTITY	Inhibition of mTOR with everolimus and silencing by vascular endothelial cell growth factor-specific siRNA induces synergistic antitumor activity in multiple_myeloma cells .
25014496	0	everolimus	19,29	mTOR	0,4	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	mTOR inhibition by everolimus in childhood acute_lymphoblastic_leukemia induces caspase-independent cell death .
25287756	0	everolimus	133,143	mTOR	118,122	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Improvement Improvement|nmod|quality quality|nmod|life life|nmod|patients patients|nmod|graft-versus-host_disease graft-versus-host_disease|acl|treated treated|nmod|inhibitor inhibitor|compound|END_ENTITY	Improvement of quality of life in patients with steroid-refractory chronic graft-versus-host_disease treated with the mTOR inhibitor everolimus .
25404014	0	everolimus	125,135	mTOR	110,114	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|inhibitor inhibitor|compound|END_ENTITY	A comprehensively characterized large panel of head_and_neck_cancer patient-derived xenografts identifies the mTOR inhibitor everolimus as potential new treatment option .
25442249	0	everolimus	87,97	mTOR	0,4	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|stomatitis stomatitis|amod|END_ENTITY	mTOR inhibitor-associated stomatitis -LRB- mIAS -RRB- in three patients with cancer treated with everolimus .
25663547	0	everolimus	40,50	mTOR	25,29	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|activity activity|nmod|inhibitor inhibitor|compound|END_ENTITY	In vitro activity of the mTOR inhibitor everolimus , in a large panel of breast_cancer cell lines and analysis for predictors of response .
25982012	0	everolimus	91,101	mTOR	76,80	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|activity activity|nmod|vandetanib vandetanib|acl|combined combined|nmod|inhibitor inhibitor|compound|END_ENTITY	Systemic and CNS activity of the RET inhibitor vandetanib combined with the mTOR inhibitor everolimus in KIF5B-RET re-arranged non-small_cell_lung_cancer with brain metastases .
26073719	0	everolimus	30,40	mTOR	15,19	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|inhibitor inhibitor|compound|END_ENTITY	Effects of the mTOR inhibitor everolimus and the PI3K/mTOR inhibitor NVP-BEZ235 in murine acute_lung_injury models .
26289591	0	everolimus	36,46	mTOR	20,24	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	inhibitors|dobj|START_ENTITY inhibitors|csubj|Differentiating Differentiating|dobj|END_ENTITY	Differentiating the mTOR inhibitors everolimus and sirolimus in the treatment of tuberous_sclerosis complex .
26289591	0	everolimus	36,46	mTOR	20,24	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	inhibitors|dobj|START_ENTITY inhibitors|csubj|Differentiating Differentiating|dobj|END_ENTITY	Differentiating the mTOR inhibitors everolimus and sirolimus in the treatment of tuberous_sclerosis complex .
26543807	0	everolimus	26,36	mTOR	11,15	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Use Use|nmod|inhibitor inhibitor|compound|END_ENTITY	Use of the mTOR inhibitor everolimus in a patient with multiple manifestations of tuberous_sclerosis complex including epilepsy .
26847859	0	everolimus	62,72	mTOR	0,4	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY treatment|dep|role treatment|compound|END_ENTITY	mTOR treatment in lymphangioleiomyomatosis -LRB- LAM -RRB- : the role of everolimus .
26861608	0	everolimus	20,30	mTOR	44,48	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	START_ENTITY|appos|plus plus|compound|END_ENTITY	A phase II study of everolimus -LRB- RAD001 -RRB- , an mTOR inhibitor plus CHOP for newly diagnosed peripheral_T-cell_lymphomas .
27063582	0	everolimus	8,18	mTOR	82,86	everolimus	mTOR	MESH:C107135	21977(Tax:10090)	Chemical	Gene	RAD001|dep|START_ENTITY attenuates|nsubj|RAD001 attenuates|advcl|inhibiting inhibiting|dobj|END_ENTITY	RAD001 -LRB- everolimus -RRB- attenuates experimental autoimmune neuritis by inhibiting the mTOR pathway , elevating Akt activity and polarizing M2 macrophages .
20382200	0	everolimus	32,42	mTORC1	14,20	everolimus	mTORC1	MESH:C107135	382056(Tax:10090)	Chemical	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of mTORC1 by RAD001 -LRB- everolimus -RRB- potentiates the effects of 1,25-dihydroxyvitamin _ D -LRB- 3 -RRB- to induce growth_arrest and differentiation of AML cells in vitro and in vivo .
18332469	0	everolimus	90,100	mammalian_target_of_rapamycin	47,76	everolimus	mammalian target of rapamycin	MESH:C107135	2475	Chemical	Gene	pathway|nmod|START_ENTITY pathway|compound|END_ENTITY	Dose - and schedule-dependent inhibition of the mammalian_target_of_rapamycin pathway with everolimus : a phase I tumor pharmacodynamic study in patients with advanced solid tumors .
18332470	0	everolimus	102,112	mammalian_target_of_rapamycin	62,91	everolimus	mammalian target of rapamycin	MESH:C107135	2475	Chemical	Gene	START_ENTITY|nsubj|study study|nmod|inhibitor inhibitor|compound|END_ENTITY	Phase I pharmacokinetic and pharmacodynamic study of the oral mammalian_target_of_rapamycin inhibitor everolimus in patients with advanced solid tumors .
20005385	0	everolimus	75,85	mammalian_target_of_rapamycin	28,57	everolimus	mammalian target of rapamycin	MESH:C107135	2475	Chemical	Gene	START_ENTITY|nsubj|Immunosuppression Immunosuppression|acl|using using|dobj|inhibitor inhibitor|compound|END_ENTITY	Immunosuppression using the mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitor everolimus : pilot study shows significant cognitive and affective improvement .
20142598	0	everolimus	67,77	mammalian_target_of_rapamycin	27,56	everolimus	mammalian target of rapamycin	MESH:C107135	2475	Chemical	Gene	START_ENTITY|nsubj|trial trial|nmod|inhibitor inhibitor|compound|END_ENTITY	Phase II trial of the oral mammalian_target_of_rapamycin inhibitor everolimus in relapsed or refractory Waldenstrom_macroglobulinemia .
20681032	0	everolimus	69,79	mammalian_target_of_rapamycin	28,57	everolimus	mammalian target of rapamycin	MESH:C107135	2475	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	A phase 2 study of the oral mammalian_target_of_rapamycin inhibitor , everolimus , in patients with recurrent endometrial_carcinoma .
20972652	0	everolimus	66,76	mammalian_target_of_rapamycin	26,55	everolimus	mammalian target of rapamycin	MESH:C107135	2475	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|study study|nmod|END_ENTITY	Phase I study of the oral mammalian_target_of_rapamycin inhibitor everolimus -LRB- RAD001 -RRB- in Japanese patients with relapsed or refractory_non-Hodgkin_lymphoma .
21064094	0	everolimus	57,67	mammalian_target_of_rapamycin	14,43	everolimus	mammalian target of rapamycin	MESH:C107135	2475	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Inhibition of mammalian_target_of_rapamycin signaling by everolimus induces senescence in adult_T-cell_leukemia / lymphoma and apoptosis in peripheral_T-cell_lymphomas .
23838481	0	everolimus	69,79	mammalian_target_of_rapamycin	16,45	everolimus	mammalian target of rapamycin	MESH:C107135	2475	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|effects effects|nmod|END_ENTITY	Bone effects of mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibition with everolimus .
24557436	0	everolimus	70,80	mammalian_target_of_rapamycin	30,59	everolimus	mammalian target of rapamycin	MESH:C107135	2475	Chemical	Gene	START_ENTITY|csubj|Phase Phase|xcomp|trial trial|nmod|inhibitor inhibitor|compound|END_ENTITY	Phase I clinical trial of the mammalian_target_of_rapamycin inhibitor everolimus in combination with oral topotecan for recurrent and advanced endometrial_cancer .
24964967	0	everolimus	57,67	mammalian_target_of_rapamycin	14,43	everolimus	mammalian target of rapamycin	MESH:C107135	2475	Chemical	Gene	Targeting|nmod|START_ENTITY Targeting|dobj|END_ENTITY	Targeting the mammalian_target_of_rapamycin pathway with everolimus : Implications for the management of metastatic breast_cancer .
19426700	0	everolimus	15,25	mdr1a	29,34	everolimus	mdr1a	MESH:C107135	18671(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Disposition of everolimus in mdr1a - / 1b - mice and after a pre-treatment of lapatinib in Swiss mice .
20503248	0	evodiamine	30,40	ARO	75,78	evodiamine	ARO	MESH:C049639	1588	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nsubj|effects	Anti-proliferative effects of evodiamine on human thyroid_cancer cell line ARO .
26354012	0	evodiamine	11,21	TRPV1	71,76	evodiamine	TRPV1	MESH:C049639	7442	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of evodiamine , a major alkaloid of Goshuyu -LRB- Evodia Fruits -RRB- , on TRPV1 .
26621343	0	evogliptin	94,104	dipeptidyl_peptidase_4	60,82	evogliptin	dipeptidyl peptidase 4	null	13482(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Hepatic role in an early glucose-lowering effect by a novel dipeptidyl_peptidase_4 inhibitor , evogliptin , in a rodent model of type 2 diabetes .
25336915	0	evogliptin	55,65	dipeptidyl_peptidase_IV	85,108	evogliptin	dipeptidyl peptidase IV	null	1803	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY pharmacokinetics|appos|inhibitor inhibitor|amod|END_ENTITY	Multiple-dose pharmacokinetics and pharmacodynamics of evogliptin -LRB- DA-1229 -RRB- , a novel dipeptidyl_peptidase_IV inhibitor , in healthy volunteers .
18301888	0	exopolysaccharide	21,38	B-1355	88,94	exopolysaccharide	B-1355	CHEBI:72813	945907(Tax:511145)	Chemical	Gene	mutants|amod|START_ENTITY mutants|nmod|END_ENTITY	Biofilm formation by exopolysaccharide mutants of Leuconostoc_mesenteroides_strain NRRL B-1355 .
10787062	0	extensin	8,16	peroxidase	17,27	extensin	peroxidase	null	543959(Tax:4081)	Chemical	Gene	Role|nmod|START_ENTITY END_ENTITY|dep|Role	Role of extensin peroxidase in tomato -LRB- Lycopersicon_esculentum_Mill . -RRB-
22047626	0	ezatiostat	181,191	GSTP1-1	227,234	ezatiostat	GSTP1-1	null	2950	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|appos|END_ENTITY	Oral ezatiostat HCl -LRB- Telintra , TLK199 -RRB- and idiopathic_chronic_neutropenia -LRB- ICN -RRB- : a case report of complete response of a patient with G-CSF resistant ICN following treatment with ezatiostat , a glutathione_S-transferase_P1-1 -LRB- GSTP1-1 -RRB- inhibitor .
22047626	0	ezatiostat	181,191	glutathione_S-transferase_P1-1	195,225	ezatiostat	glutathione S-transferase P1-1	null	2950	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Oral ezatiostat HCl -LRB- Telintra , TLK199 -RRB- and idiopathic_chronic_neutropenia -LRB- ICN -RRB- : a case report of complete response of a patient with G-CSF resistant ICN following treatment with ezatiostat , a glutathione_S-transferase_P1-1 -LRB- GSTP1-1 -RRB- inhibitor .
15899106	0	ezetimibe	43,52	LDL-C	0,5	ezetimibe	LDL-C	MESH:C108606	22796	Chemical	Gene	addition|nmod|START_ENTITY attainment|nmod|addition attainment|nsubj|goal goal|amod|END_ENTITY	LDL-C goal attainment with the addition of ezetimibe to ongoing simvastatin treatment in coronary_heart_disease patients with hypercholesterolemia .
15982505	0	ezetimibe	27,36	LDL-C	76,81	ezetimibe	LDL-C	MESH:C108606	22796	Chemical	Gene	START_ENTITY|nmod|treatment treatment|nmod|goal goal|amod|END_ENTITY	Effect of co-administering ezetimibe with on-going simvastatin treatment on LDL-C goal attainment in hypercholesterolemic patients with coronary_heart_disease .
16369229	0	ezetimibe	27,36	LDL-C	0,5	ezetimibe	LDL-C	MESH:C108606	22796	Chemical	Gene	attainment|nmod|START_ENTITY attainment|amod|END_ENTITY	LDL-C goal attainment with ezetimibe plus simvastatin coadministration vs atorvastatin or simvastatin monotherapy in patients at high risk of CHD .
16638916	0	ezetimibe	61,70	LDL-C	43,48	ezetimibe	LDL-C	MESH:C108606	22796	Chemical	Gene	response|acl|START_ENTITY response|amod|END_ENTITY	Type of preexisting lipid therapy predicts LDL-C response to ezetimibe .
17036098	0	ezetimibe	29,38	LDL-C	149,154	ezetimibe	LDL-C	MESH:C108606	22796	Chemical	Gene	10|amod|START_ENTITY Efficacy|nmod|10 coadministered|nsubj|Efficacy coadministered|nmod|primary_hypercholesterolemia primary_hypercholesterolemia|acl:relcl|achieve achieve|dobj|END_ENTITY	Efficacy and tolerability of ezetimibe 10 mg/day coadministered with statins in patients with primary_hypercholesterolemia who do not achieve target LDL-C while on statin monotherapy : A Canadian , multicentre , prospective study -- the Ezetrol Add-On Study .
17451281	0	ezetimibe	28,37	LDL-C	119,124	ezetimibe	LDL-C	MESH:C108606	22796	Chemical	Gene	Effectiveness|nmod|START_ENTITY added|nsubj|Effectiveness added|xcomp|statin statin|advcl|achieving achieving|dobj|goal goal|amod|END_ENTITY	Effectiveness and safety of ezetimibe added to statin therapy in patients with primary_dyslipidaemia not achieving the LDL-C treatment goal on statin monotherapy .
24094079	0	ezetimibe	42,51	LDL-C	74,79	ezetimibe	LDL-C	MESH:C108606	22796	Chemical	Gene	therapy|amod|START_ENTITY therapy|nmod|Goal Goal|compound|END_ENTITY	RESEARCH -LRB- Recognized effect of Statin and ezetimibe therapy for achieving LDL-C Goal -RRB- , a randomized , doctor-oriented , multicenter trial to compare the effects of higher-dose statin versus ezetimibe-plus-statin on the serum LDL-C concentration of Japanese type-2 diabetes patients design and rationale .
20880342	0	ezetimibe	31,40	LDL-c	57,62	ezetimibe	LDL-c	MESH:C108606	22796	Chemical	Gene	uses|nmod|START_ENTITY uses|advcl|lowering lowering|xcomp|END_ENTITY	Potential therapeutic uses for ezetimibe beyond lowering LDL-c to decrease cardiovascular events .
19305020	0	ezetimibe	11,20	apolipoprotein_B	40,56	ezetimibe	apolipoprotein B	MESH:C108606	338	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|metabolism metabolism|amod|END_ENTITY	Effects of ezetimibe and simvastatin on apolipoprotein_B metabolism in males with mixed_hyperlipidemia .
22196962	0	ezetimibe	8,17	familial_hypercholesterolemia	38,67	ezetimibe	familial hypercholesterolemia	MESH:C108606	3949	Chemical	Gene	START_ENTITY|nmod|treatment treatment|nmod|END_ENTITY	-LSB- Use of ezetimibe in the treatment of familial_hypercholesterolemia in children and adolescents -RSB- .
18627322	0	ezetimibe	11,20	visfatin	81,89	ezetimibe	visfatin	MESH:C108606	10135	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|compound|END_ENTITY	Effects of ezetimibe , either alone or in combination with atorvastatin , on serum visfatin levels : a pilot study .
24094079	0	ezetimibe-plus-statin	188,209	LDL-C	223,228	ezetimibe-plus-statin	LDL-C	null	22796	Chemical	Gene	START_ENTITY|nmod|concentration concentration|compound|END_ENTITY	RESEARCH -LRB- Recognized effect of Statin and ezetimibe therapy for achieving LDL-C Goal -RRB- , a randomized , doctor-oriented , multicenter trial to compare the effects of higher-dose statin versus ezetimibe-plus-statin on the serum LDL-C concentration of Japanese type-2 diabetes patients design and rationale .
15963082	0	famotidine	32,42	CYP2C19	102,109	famotidine	CYP2C19	MESH:D015738	1557	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|status status|compound|END_ENTITY	Effect of concomitant dosing of famotidine with lansoprazole on gastric_acid secretion in relation to CYP2C19 genotype status .
1362785	0	famotidine	11,21	gastrin	25,32	famotidine	gastrin	MESH:D015738	25320(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|cell cell|compound|END_ENTITY	-LSB- Effect of famotidine on gastrin cell , somatostatin cell , and prostaglandin_E2 concentration of stomach in experimental pyloric_stenosis model -RSB- .
17105418	0	famotidine	62,72	interleukin-2	151,164	famotidine	interleukin-2	MESH:D015738	3558	Chemical	Gene	Activity|nmod|START_ENTITY Activity|acl|treated treated|nmod|END_ENTITY	Activity of continuous infusion plus pulse interleukin-2 with famotidine in patients with metastatic kidney_cancer or melanoma previously treated with interleukin-2 .
17105418	0	famotidine	62,72	interleukin-2	43,56	famotidine	interleukin-2	MESH:D015738	3558	Chemical	Gene	Activity|nmod|START_ENTITY Activity|nmod|END_ENTITY	Activity of continuous infusion plus pulse interleukin-2 with famotidine in patients with metastatic kidney_cancer or melanoma previously treated with interleukin-2 .
19243244	0	famotidine	59,69	interleukin-2	40,53	famotidine	interleukin-2	MESH:D015738	3558	Chemical	Gene	+|nmod|START_ENTITY +|dobj|END_ENTITY	Activity of continuous infusion + pulse interleukin-2 with famotidine in metastatic_melanoma .
20965180	0	farnesoic_acid	79,93	PHO81	17,22	farnesoic acid	PHO81	MESH:C007702	853148(Tax:4932)	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Candida_albicans PHO81 is required for the inhibition of hyphal development by farnesoic_acid .
7592846	0	farnesyl	4,12	H-Ras	22,27	farnesyl	H-Ras	CHEBI:24017	399406(Tax:8355)	Chemical	Gene	group|amod|START_ENTITY group|nmod|END_ENTITY	The farnesyl group of H-Ras facilitates the activation of a soluble upstream activator of mitogen-activated protein kinase .
9376347	0	farnesyl	25,33	H-Ras	19,24	farnesyl	H-Ras	CHEBI:24017	399406(Tax:8355)	Chemical	Gene	group|compound|START_ENTITY group|compound|END_ENTITY	Replacement of the H-Ras farnesyl group by lipid analogues : implications for downstream processing and effector activation in Xenopus oocytes .
12758256	0	farnesyl_diphosphate	13,33	ERG9	56,60	farnesyl diphosphate	ERG9	MESH:C004808	856597(Tax:4932)	Chemical	Gene	accumulation|amod|START_ENTITY accumulation|nmod|END_ENTITY	Detection of farnesyl_diphosphate accumulation in yeast ERG9 mutants .
19056481	0	farnesyl_diphosphate	77,97	FDPS	110,114	farnesyl diphosphate	FDPS	MESH:C004808	2224	Chemical	Gene	synthetase|compound|START_ENTITY synthetase|appos|END_ENTITY	Characterization and functional analysis of cis-acting elements of the human farnesyl_diphosphate synthetase -LRB- FDPS -RRB- gene 5 ' flanking region .
24793581	0	farnesyl_pyrophosphate	38,60	erg20	18,23	farnesyl pyrophosphate	erg20	MESH:C004808	853272(Tax:4932)	Chemical	Gene	synthase|compound|START_ENTITY synthase|amod|END_ENTITY	Overexpression of erg20 gene encoding farnesyl_pyrophosphate synthase has contrasting effects on activity of enzymes of the dolichyl and sterol branches of mevalonate pathway in Trichoderma_reesei .
18171730	0	farnesyl_thiosalicylic_acid	23,50	TRPA1	14,19	farnesyl thiosalicylic acid	TRPA1	MESH:C093323	8989	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of TRPA1 by farnesyl_thiosalicylic_acid .
22512549	0	fascaplysin	25,36	CDK-4	62,67	fascaplysin	CDK-4	null	1019	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Chemistry and biology of fascaplysin , a potent marine-derived CDK-4 inhibitor .
10973815	0	fascaplysin	50,61	Cdk4	41,45	fascaplysin	Cdk4	null	1019	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of cyclin-dependent_kinase_4 -LRB- Cdk4 -RRB- by fascaplysin , a marine natural product .
10973815	0	fascaplysin	50,61	cyclin-dependent_kinase_4	14,39	fascaplysin	cyclin-dependent kinase 4	null	1019	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of cyclin-dependent_kinase_4 -LRB- Cdk4 -RRB- by fascaplysin , a marine natural product .
18369695	0	fasudil	29,36	Rho-Kinase	47,57	fasudil	Rho-Kinase	MESH:C049347	19878(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Antiangiogenic properties of fasudil , a potent Rho-Kinase inhibitor .
20665603	0	fasudil	89,96	TNF-a	42,47	fasudil	TNF-a	MESH:C049347	7124	Chemical	Gene	cells|nmod|START_ENTITY Modification|nmod|cells Modification|nmod|effect effect|nmod|END_ENTITY	Modification of the detrimental effect of TNF-a on human endothelial progenitor cells by fasudil and Y27632 .
10879764	0	fasudil_hydrochloride	29,50	Protein_kinase	0,14	fasudil hydrochloride	Protein kinase	MESH:C049347	64030(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Protein_kinase inhibition by fasudil_hydrochloride promotes neurological recovery after spinal_cord_injury in rats .
20203611	0	fatty-acid	30,40	SIRT3	0,5	fatty-acid	SIRT3	CHEBI:35366	64384(Tax:10090)	Chemical	Gene	oxidation|amod|START_ENTITY regulates|dobj|oxidation regulates|nsubj|END_ENTITY	SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation .
25721401	0	fatty_acid	32,42	ACAD9	72,77	fatty acid	ACAD9	CHEBI:35366	28976	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Complex I assembly function and fatty_acid oxidation enzyme activity of ACAD9 both contribute to disease severity in ACAD9_deficiency .
8496932	2	fatty_acid	78,88	ACAT	97,101	fatty acid	ACAT	CHEBI:35366	1066	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Modification of fatty_acid anilide ACAT inhibitors : bioisosteric replacement of the amide bond .
24240094	0	fatty_acid	42,52	AMP-activated_kinase	68,88	fatty acid	AMP-activated kinase	CHEBI:35366	5563	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|nmod|END_ENTITY	Glucose regulates hypothalamic long-chain fatty_acid metabolism via AMP-activated_kinase -LRB- AMPK -RRB- in neurons and astrocytes .
19448692	0	fatty_acid	55,65	AMP-activated_protein_kinase	12,40	fatty acid	AMP-activated protein kinase	CHEBI:35366	5563	Chemical	Gene	metabolism|amod|START_ENTITY regulating|dobj|metabolism END_ENTITY|acl|regulating	Role of the AMP-activated_protein_kinase in regulating fatty_acid metabolism during exercise .
22750049	0	fatty_acid	19,29	AMPK	0,4	fatty acid	AMPK	CHEBI:35366	5563	Chemical	Gene	metabolism|amod|START_ENTITY regulation|nmod|metabolism regulation|compound|END_ENTITY	AMPK regulation of fatty_acid metabolism and mitochondrial biogenesis : implications for obesity .
24013029	0	fatty_acid	21,31	AMPK	142,146	fatty acid	AMPK	CHEBI:35366	78975(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Genistein stimulates fatty_acid oxidation in a leptin receptor-independent manner through the JAK2-mediated phosphorylation and activation of AMPK in skeletal muscle .
16936205	0	fatty_acid	22,32	Adiponectin	0,11	fatty acid	Adiponectin	CHEBI:35366	9370	Chemical	Gene	START_ENTITY|nsubj|increases increases|compound|END_ENTITY	Adiponectin increases fatty_acid oxidation in skeletal muscle cells by sequential activation of AMP-activated protein kinase , p38_mitogen-activated_protein_kinase , and peroxisome_proliferator-activated_receptor_alpha .
23261986	0	fatty_acid	18,28	Amylin	0,6	fatty acid	Amylin	CHEBI:35366	3375	Chemical	Gene	START_ENTITY|nsubj|stimulates stimulates|compound|END_ENTITY	Amylin stimulates fatty_acid esterification in 3T3-L1 adipocytes .
23555925	0	fatty_acid	33,43	B-FABP	61,67	fatty acid	B-FABP	CHEBI:35366	2173	Chemical	Gene	START_ENTITY|dobj|protein protein|appos|END_ENTITY	Probing the interaction of brain fatty_acid binding protein -LRB- B-FABP -RRB- with model membranes .
19112106	0	fatty_acid	47,57	BmFATP	77,83	fatty acid	BmFATP	CHEBI:35366	100174941(Tax:7091)	Chemical	Gene	START_ENTITY|dobj|protein protein|appos|END_ENTITY	Functional characterization of the Bombyx_mori fatty_acid transport protein -LRB- BmFATP -RRB- within the silkmoth pheromone gland .
18191860	0	fatty_acid	39,49	Bradykinin	0,10	fatty acid	Bradykinin	CHEBI:35366	280833(Tax:9913)	Chemical	Gene	stimulates|ccomp|START_ENTITY stimulates|nsubj|END_ENTITY	Bradykinin stimulates endothelial cell fatty_acid oxidation by CaMKK-dependent activation of AMPK .
17641279	0	fatty_acid	67,77	C5L2	91,95	fatty acid	C5L2	CHEBI:35366	319430(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|compound|END_ENTITY	Reduced adipose tissue triglyceride synthesis and increased muscle fatty_acid oxidation in C5L2 knockout mice .
10331667	0	fatty_acid	134,144	CD36	0,4	fatty acid	CD36	CHEBI:35366	948	Chemical	Gene	mediates|parataxis|START_ENTITY mediates|nsubj|END_ENTITY	CD36 mediates long-chain fatty_acid transport in human myocardium : complete myocardial accumulation defect of radiolabeled long-chain fatty_acid analog in subjects with CD36_deficiency .
10331667	0	fatty_acid	25,35	CD36	0,4	fatty acid	CD36	CHEBI:35366	948	Chemical	Gene	transport|amod|START_ENTITY mediates|dobj|transport mediates|nsubj|END_ENTITY	CD36 mediates long-chain fatty_acid transport in human myocardium : complete myocardial accumulation defect of radiolabeled long-chain fatty_acid analog in subjects with CD36_deficiency .
10383407	0	fatty_acid	60,70	CD36	26,30	fatty acid	CD36	CHEBI:35366	12491(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY role|nmod|metabolism reveals|dobj|role reveals|nsubj|mutation mutation|nmod|END_ENTITY	A null mutation in murine CD36 reveals an important role in fatty_acid and lipoprotein metabolism .
10526223	0	fatty_acid	43,53	CD36	81,85	fatty acid	CD36	CHEBI:35366	948	Chemical	Gene	uptake|amod|START_ENTITY implicated|nmod|uptake proteins|acl|implicated proteins|dep|END_ENTITY	Membrane proteins implicated in long-chain fatty_acid uptake by mammalian cells : CD36 , FATP and FABPm .
10913136	9	fatty_acid	1518,1528	CD36	1481,1485	fatty acid	CD36	CHEBI:35366	948	Chemical	Gene	uptake|amod|START_ENTITY fraction|nmod|uptake facilitates|dobj|fraction facilitates|nsubj|END_ENTITY	It is concluded that CD36 facilitates a large fraction of fatty_acid uptake by heart , skeletal muscle , and adipose tissues and that CD36_deficiency in humans is the cause of the reported defect in myocardial BMIPP uptake .
11141076	0	fatty_acid	104,114	CD36	84,88	fatty acid	CD36	CHEBI:35366	948	Chemical	Gene	uptake|amod|START_ENTITY facilitate|dobj|uptake facilitate|nsubj|Interaction Interaction|nmod|complexes complexes|nmod|END_ENTITY	Interaction of S100A8/S100A9-arachidonic _ acid complexes with the scavenger receptor CD36 may facilitate fatty_acid uptake by endothelial cells .
11718687	0	fatty_acid	61,71	CD36	28,32	fatty acid	CD36	CHEBI:35366	948	Chemical	Gene	concentrations|amod|START_ENTITY mutation|nmod|concentrations mutation|nsubj|Association Association|nmod|END_ENTITY	Association of the Pro90Ser CD36 mutation with elevated free fatty_acid concentrations but not with insulin_resistance_syndrome in Japanese .
12054519	0	fatty_acid	4,14	CD36	33,37	fatty acid	CD36	CHEBI:35366	29184(Tax:10116)	Chemical	Gene	translocase|amod|START_ENTITY translocase|dep|END_ENTITY	The fatty_acid translocase -LRB- FAT -RRB- / CD36 and the glucose transporter GLUT4 are localized in different cellular compartments in rat cardiac muscle .
12479585	0	fatty_acid	47,57	CD36	76,80	fatty acid	CD36	CHEBI:35366	948	Chemical	Gene	translocase|amod|START_ENTITY translocase|dep|END_ENTITY	The impact of overexpression and deficiency of fatty_acid translocase -LRB- FAT -RRB- / CD36 .
14740222	0	fatty_acid	34,44	CD36	63,67	fatty acid	CD36	CHEBI:35366	948	Chemical	Gene	translocase|amod|START_ENTITY immunolocalisation|nmod|translocase immunolocalisation|dep|END_ENTITY	Subcellular immunolocalisation of fatty_acid translocase -LRB- FAT -RRB- / CD36 in human type-1 and type-2 skeletal muscle fibres .
15161924	0	fatty_acid	21,31	CD36	50,54	fatty acid	CD36	CHEBI:35366	948	Chemical	Gene	translocase|amod|START_ENTITY function|nmod|translocase END_ENTITY|dep|function	A novel function for fatty_acid translocase -LRB- FAT -RRB- / CD36 : involvement in long chain fatty_acid transfer into the mitochondria .
15282206	0	fatty_acid	66,76	CD36	26,30	fatty acid	CD36	CHEBI:35366	948	Chemical	Gene	levels|amod|START_ENTITY associated|nmod|levels associated|nsubjpass|haplotype haplotype|nmod|locus locus|nummod|END_ENTITY	A common haplotype at the CD36 locus is associated with high free fatty_acid levels and increased cardiovascular risk in Caucasians .
16357012	0	fatty_acid	25,35	CD36	70,74	fatty acid	CD36	CHEBI:35366	948	Chemical	Gene	START_ENTITY|dobj|content content|compound|END_ENTITY	Mitochondrial long chain fatty_acid oxidation , fatty_acid_translocase / CD36 content and carnitine_palmitoyltransferase_I activity in human skeletal muscle during aerobic exercise .
17291449	0	fatty_acid	31,41	CD36	67,71	fatty acid	CD36	CHEBI:35366	948	Chemical	Gene	uptake|amod|START_ENTITY inhibits|dobj|uptake inhibits|advcl|affecting affecting|dobj|distribution distribution|compound|END_ENTITY	Cholesterol depletion inhibits fatty_acid uptake without affecting CD36 or caveolin-1 distribution in adipocytes .
17292863	0	fatty_acid	48,58	CD36	100,104	fatty acid	CD36	CHEBI:35366	12491(Tax:10090)	Chemical	Gene	START_ENTITY|ccomp|depends depends|nmod|END_ENTITY	AMPK-mediated increase in myocardial long-chain fatty_acid uptake critically depends on sarcolemmal CD36 .
17507371	0	fatty_acid	22,32	CD36	0,4	fatty acid	CD36	CHEBI:35366	12491(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY important|nmod|uptake important|nsubj|END_ENTITY	CD36 is important for fatty_acid and cholesterol uptake by the proximal but not distal intestine .
18203888	0	fatty_acid	50,60	CD36	0,4	fatty acid	CD36	CHEBI:35366	12491(Tax:10090)	Chemical	Gene	pathways|nmod|START_ENTITY pathways|compound|END_ENTITY	CD36 and proteoglycan-mediated pathways for -LRB- n-3 -RRB- fatty_acid enriched triglyceride-rich particle blood clearance in mouse models in vivo and in peritoneal macrophages in vitro .
18353783	0	fatty_acid	82,92	CD36	23,27	fatty acid	CD36	CHEBI:35366	948	Chemical	Gene	uptake|amod|START_ENTITY effects|nmod|uptake regulation|dep|effects regulation|nmod|ubiquitination ubiquitination|nummod|END_ENTITY	Opposite regulation of CD36 ubiquitination by fatty_acids and insulin : effects on fatty_acid uptake .
19666541	0	fatty_acid	36,46	CD36	66,70	fatty acid	CD36	CHEBI:35366	12491(Tax:10090)	Chemical	Gene	sensor|amod|START_ENTITY functions|nmod|sensor functions|nmod|expression expression|compound|END_ENTITY	TR4 nuclear receptor functions as a fatty_acid sensor to modulate CD36 expression and foam cell formation .
19931418	0	fatty_acid	140,150	CD36	37,41	fatty acid	CD36	CHEBI:35366	948	Chemical	Gene	oxidation|amod|START_ENTITY secretion|nmod|oxidation reduces|dobj|secretion reduces|nsubj|Facilitation Facilitation|nmod|uptake uptake|nmod|END_ENTITY	Facilitation of fatty_acid uptake by CD36 in insulin-producing cells reduces fatty-acid-induced insulin secretion and glucose regulation of fatty_acid oxidation .
19931418	0	fatty_acid	16,26	CD36	37,41	fatty acid	CD36	CHEBI:35366	948	Chemical	Gene	uptake|amod|START_ENTITY uptake|nmod|END_ENTITY	Facilitation of fatty_acid uptake by CD36 in insulin-producing cells reduces fatty-acid-induced insulin secretion and glucose regulation of fatty_acid oxidation .
20117238	0	fatty_acid	49,59	CD36	82,86	fatty acid	CD36	CHEBI:35366	948	Chemical	Gene	START_ENTITY|advcl|reducing reducing|dobj|transporters transporters|compound|END_ENTITY	HIV-protease inhibitors suppress skeletal muscle fatty_acid oxidation by reducing CD36 and CPT1 fatty_acid transporters .
20117238	0	fatty_acid	96,106	CD36	82,86	fatty acid	CD36	CHEBI:35366	948	Chemical	Gene	transporters|compound|START_ENTITY transporters|compound|END_ENTITY	HIV-protease inhibitors suppress skeletal muscle fatty_acid oxidation by reducing CD36 and CPT1 fatty_acid transporters .
20683255	0	fatty_acid	97,107	CD36	131,135	fatty acid	CD36	CHEBI:35366	29184(Tax:10116)	Chemical	Gene	oxidation|compound|START_ENTITY regulation|nmod|oxidation regulation|dep|dehydrogenase dehydrogenase|compound|END_ENTITY	Metabolic profiling of hearts exposed to sevoflurane and propofol reveals distinct regulation of fatty_acid and glucose oxidation : CD36 and pyruvate dehydrogenase as key regulators in anesthetic-induced fuel shift .
21172358	0	fatty_acid	60,70	CD36	15,19	fatty acid	CD36	CHEBI:35366	948	Chemical	Gene	transport|amod|START_ENTITY Involvement|nmod|transport Involvement|nmod|END_ENTITY	Involvement of CD36 and intestinal_alkaline_phosphatases in fatty_acid transport in enterocytes , and the response to a high-fat diet .
21270117	0	fatty_acid	8,18	CD36	31,35	fatty acid	CD36	CHEBI:35366	948	Chemical	Gene	START_ENTITY|ccomp|associated associated|nsubjpass|upregulation upregulation|compound|END_ENTITY	Hepatic fatty_acid translocase CD36 upregulation is associated with insulin resistance , hyperinsulinaemia and increased_steatosis in non-alcoholic_steatohepatitis and chronic_hepatitis_C .
21346626	0	fatty_acid	30,40	CD36	24,28	fatty acid	CD36	CHEBI:35366	948	Chemical	Gene	translocase|amod|START_ENTITY gene|appos|translocase gene|amod|END_ENTITY	Common variation in the CD36 -LRB- fatty_acid translocase -RRB- gene is associated with left-ventricular mass .
21865651	0	fatty_acid	36,46	CD36	69,73	fatty acid	CD36	CHEBI:35366	948	Chemical	Gene	metabolism|amod|START_ENTITY regulate|dobj|metabolism regulate|advcl|tagging tagging|dobj|END_ENTITY	Parkin reinvents itself to regulate fatty_acid metabolism by tagging CD36 .
22022213	0	fatty_acid	81,91	CD36	18,22	fatty acid	CD36	CHEBI:35366	948	Chemical	Gene	uptake|amod|START_ENTITY increases|dobj|uptake increases|nsubj|Overexpression Overexpression|nmod|FATP4 FATP4|compound|END_ENTITY	Overexpression of CD36 and acyl-CoA synthetases FATP2 , FATP4 and ACSL1 increases fatty_acid uptake in human hepatoma cells .
22430143	0	fatty_acid	14,24	CD36	61,65	fatty acid	CD36	CHEBI:35366	948	Chemical	Gene	cluster_determinant_36|amod|START_ENTITY cluster_determinant_36|appos|END_ENTITY	Inhibition of fatty_acid translocase cluster_determinant_36 -LRB- CD36 -RRB- , stimulated by hyperglycemia , prevents glucotoxicity in INS-1 cells .
22463611	0	fatty_acid	20,30	CD36	55,59	fatty acid	CD36	CHEBI:35366	12491(Tax:10090)	Chemical	Gene	oxidation|amod|START_ENTITY blunted|nsubjpass|oxidation blunted|nmod|mice mice|nummod|END_ENTITY	Caffeine-stimulated fatty_acid oxidation is blunted in CD36 null mice .
22584574	0	fatty_acid	9,19	CD36	33,37	fatty acid	CD36	CHEBI:35366	12491(Tax:10090)	Chemical	Gene	translocase|amod|START_ENTITY translocase|appos|END_ENTITY	In vivo , fatty_acid translocase -LRB- CD36 -RRB- critically regulates skeletal muscle fuel selection , exercise performance , and training-induced adaptation of fatty_acid oxidation .
23448206	0	fatty_acid	30,40	CD36	94,98	fatty acid	CD36	CHEBI:35366	948	Chemical	Gene	START_ENTITY|advcl|downregulating downregulating|dobj|expression expression|compound|END_ENTITY	Molecular hydrogen attenuates fatty_acid uptake and lipid accumulation through downregulating CD36 expression in HepG2 cells .
24784828	0	fatty_acid	103,113	CD36	37,41	fatty acid	CD36	CHEBI:35366	948	Chemical	Gene	homeostasis|amod|START_ENTITY highlights|nmod|homeostasis highlights|nsubj|profile profile|nmod|transcripts transcripts|nummod|END_ENTITY	Adipose and muscle tissue profile of CD36 transcripts in obese subjects highlights the role of CD36 in fatty_acid homeostasis and insulin resistance .
24784828	0	fatty_acid	103,113	CD36	95,99	fatty acid	CD36	CHEBI:35366	948	Chemical	Gene	homeostasis|amod|START_ENTITY highlights|nmod|homeostasis highlights|dobj|role role|nmod|END_ENTITY	Adipose and muscle tissue profile of CD36 transcripts in obese subjects highlights the role of CD36 in fatty_acid homeostasis and insulin resistance .
24850384	0	fatty_acid	45,55	CD36	22,26	fatty acid	CD36	CHEBI:35366	948	Chemical	Gene	transduction|amod|START_ENTITY Structure-function|nmod|transduction Structure-function|nmod|END_ENTITY	Structure-function of CD36 and importance of fatty_acid signal transduction in fat metabolism .
25070011	0	fatty_acid	48,58	CD36	0,4	fatty acid	CD36	CHEBI:35366	948	Chemical	Gene	utilization|amod|START_ENTITY required|nmod|utilization required|nsubjpass|END_ENTITY	CD36 , but not GPR120 , is required for efficient fatty_acid utilization during endurance exercise .
25157091	0	fatty_acid	44,54	CD36	33,37	fatty acid	CD36	CHEBI:35366	948	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|activation activation|nmod|links links|nummod|END_ENTITY	Regulation of AMPK activation by CD36 links fatty_acid uptake to beta-oxidation .
26424075	0	fatty_acid	14,24	CD36	36,40	fatty acid	CD36	CHEBI:35366	948	Chemical	Gene	uptake|amod|START_ENTITY uptake|nmod|END_ENTITY	Elevated free fatty_acid uptake via CD36 promotes epithelial-mesenchymal transition in hepatocellular_carcinoma .
27090938	0	fatty_acid	82,92	CD36	45,49	fatty acid	CD36	CHEBI:35366	948	Chemical	Gene	utilization|amod|START_ENTITY determinant|nmod|utilization Regulation|appos|determinant Regulation|nmod|trafficking trafficking|nmod|END_ENTITY	Regulation of the subcellular trafficking of CD36 , a major determinant of cardiac fatty_acid utilization .
8610095	0	fatty_acid	69,79	CD36	18,22	fatty acid	CD36	CHEBI:35366	948	Chemical	Gene	transport|amod|START_ENTITY effects|nmod|transport Expression|dep|effects Expression|nmod|homolog homolog|compound|END_ENTITY	Expression of the CD36 homolog -LRB- FAT -RRB- in fibroblast cells : effects on fatty_acid transport .
9788250	0	fatty_acid	23,33	CD36	47,51	fatty acid	CD36	CHEBI:35366	29184(Tax:10116)	Chemical	Gene	translocase|amod|START_ENTITY transfection|nmod|translocase transfection|appos|END_ENTITY	Stable transfection of fatty_acid translocase -LRB- CD36 -RRB- in a rat heart muscle cell line -LRB- H9c2 -RRB- .
9895283	0	fatty_acid	32,42	CD36	56,60	fatty acid	CD36	CHEBI:35366	29184(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|translocase translocase|appos|END_ENTITY	A sensitive immunoassay for rat fatty_acid translocase -LRB- CD36 -RRB- using phage antibodies selected on cell transfectants : abundant presence of fatty_acid translocase/CD36 in cardiac and red skeletal muscle and up-regulation in diabetes .
6016009	0	fatty_acid	30,40	CO-2	10,14	fatty acid	CO-2	CHEBI:35366	717	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of CO-2 and cations on fatty_acid and cholesterol synthesis by liver in vitro .
3108130	0	fatty_acid	23,33	Calcitonin	0,10	fatty acid	Calcitonin	CHEBI:35366	24241(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY synthesis|amod|END_ENTITY	Calcitonin and hepatic fatty_acid synthesis : effect of thyroparathyroidectomy on the elevation of ATP_citrate_lyase activity by refeeding of starved rats .
9916795	0	fatty_acid	77,87	Cd36	18,22	fatty acid	Cd36	CHEBI:35366	29184(Tax:10116)	Chemical	Gene	causing|dobj|START_ENTITY Identification|acl|causing Identification|nmod|END_ENTITY	Identification of Cd36 -LRB- Fat -RRB- as an insulin-resistance gene causing defective fatty_acid and glucose metabolism in hypertensive rats .
24005906	0	fatty_acid	106,116	Cyclooxygenase-2	0,16	fatty acid	Cyclooxygenase-2	CHEBI:35366	19225(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY interactions|nmod|receptor docosahexaenoic_acid|nmod|interactions modulated|nmod|docosahexaenoic_acid modulated|nsubjpass|induction induction|amod|END_ENTITY	Cyclooxygenase-2 induction in macrophages is modulated by docosahexaenoic_acid via interactions with free fatty_acid receptor 4 -LRB- FFA4 -RRB- .
19133076	0	fatty_acid	71,81	Delta12-desaturase	82,100	fatty acid	Delta12-desaturase	CHEBI:35366	100233160(Tax:7070)	Chemical	Gene	genes|amod|START_ENTITY genes|compound|END_ENTITY	Isolation and functional characterization of two independently-evolved fatty_acid Delta12-desaturase genes from insects .
20166112	0	fatty_acid	38,48	ELOVL1	12,18	fatty acid	ELOVL1	CHEBI:35366	64834	Chemical	Gene	homeostasis|amod|START_ENTITY role|nmod|homeostasis role|nmod|END_ENTITY	The role of ELOVL1 in very long-chain fatty_acid homeostasis and X-linked_adrenoleukodystrophy .
18188956	0	fatty_acid	18,28	ELOVL4	8,14	fatty acid	ELOVL4	CHEBI:35366	6785	Chemical	Gene	metabolism|amod|START_ENTITY Role|nmod|metabolism Role|nmod|END_ENTITY	Role of ELOVL4 in fatty_acid metabolism .
15855229	0	fatty_acid	127,137	Elovl3	103,109	fatty acid	Elovl3	CHEBI:35366	12686(Tax:10090)	Chemical	Gene	oxidation|amod|START_ENTITY END_ENTITY|nmod|oxidation	Differential regulation of fatty_acid elongation enzymes in brown adipocytes implies a unique role for Elovl3 during increased fatty_acid oxidation .
17304340	0	fatty_acid	44,54	Elovl4	18,24	fatty acid	Elovl4	CHEBI:35366	83603(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	Essential role of Elovl4 in very long chain fatty_acid synthesis , skin permeability barrier function , and neonatal survival .
19583790	0	fatty_acid	144,154	Etr1p	114,119	fatty acid	Etr1p	CHEBI:35366	852314(Tax:4932)	Chemical	Gene	synthase|amod|START_ENTITY END_ENTITY|nmod|synthase	A novel circuit overrides Adr1p control during expression of Saccharomyces_cerevisiae 2-trans-enoyl-ACP reductase Etr1p of mitochondrial type 2 fatty_acid synthase .
10777107	0	fatty_acid	14,24	Ex-FABP	42,49	fatty acid	Ex-FABP	CHEBI:35366	396393(Tax:9031)	Chemical	Gene	START_ENTITY|dobj|protein protein|appos|END_ENTITY	Extracellular fatty_acid binding protein -LRB- Ex-FABP -RRB- modulation by inflammatory agents : `` physiological '' acute phase response in endochondral bone formation .
11058755	0	fatty_acid	11,21	Ex-FABP	0,7	fatty acid	Ex-FABP	CHEBI:35366	396393(Tax:9031)	Chemical	Gene	lipocalin|amod|START_ENTITY END_ENTITY|dep|lipocalin	Ex-FABP : a fatty_acid binding lipocalin developmentally regulated in chicken endochondral bone formation and myogenesis .
12479589	0	fatty_acid	23,33	Ex-FABP	0,7	fatty acid	Ex-FABP	CHEBI:35366	396393(Tax:9031)	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	Ex-FABP , extracellular fatty_acid binding protein , is a stress lipocalin expressed during chicken embryo development .
14584054	0	fatty_acid	58,68	Ex-FABP	86,93	fatty acid	Ex-FABP	CHEBI:35366	396393(Tax:9031)	Chemical	Gene	START_ENTITY|dobj|gene gene|compound|END_ENTITY	Differentiation-dependent activation of the extracellular fatty_acid binding protein -LRB- Ex-FABP -RRB- gene during chondrogenesis .
9683528	0	fatty_acid	32,42	Ex-FABP	60,67	fatty acid	Ex-FABP	CHEBI:35366	396393(Tax:9031)	Chemical	Gene	START_ENTITY|dobj|protein protein|appos|END_ENTITY	Expression of the extracellular fatty_acid binding protein -LRB- Ex-FABP -RRB- during muscle fiber formation in vivo and in vitro .
11722577	0	fatty_acid	8,18	FABP	81,85	fatty acid	FABP	CHEBI:35366	2806	Chemical	Gene	START_ENTITY|ccomp|controls controls|ccomp|END_ENTITY	A novel fatty_acid response element controls the expression of the flight muscle FABP gene of the desert locust , Schistocerca gregaria .
11757913	0	fatty_acid	129,139	FABP	157,161	fatty acid	FABP	CHEBI:35366	14719(Tax:10090)	Chemical	Gene	binding|amod|START_ENTITY protein|amod|binding protein|appos|END_ENTITY	Cellular localization of the diazepam_binding_inhibitor -LRB- DBI -RRB- in the gastrointestinal tract of mice and its coexistence with the fatty_acid binding protein -LRB- FABP -RRB- .
12479583	0	fatty_acid	26,36	FABP	104,108	fatty acid	FABP	CHEBI:35366	25598(Tax:10116)	Chemical	Gene	element|amod|START_ENTITY Characterization|nmod|element END_ENTITY|nsubj|Characterization	Characterization of a new fatty_acid response element that controls the expression of the locust muscle FABP gene .
22451732	0	fatty_acid	19,29	FABP	47,51	fatty acid	FABP	CHEBI:35366	14719(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|protein protein|appos|END_ENTITY	Fasciola gigantica fatty_acid binding protein -LRB- FABP -RRB- as a prophylactic agent against Schistosoma_mansoni_infection in CD1 mice .
23395658	0	fatty_acid	89,99	FABP	117,121	fatty acid	FABP	CHEBI:35366	2806	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Structure-guided design , synthesis and in vitro evaluation of a series of pyrazole-based fatty_acid binding protein -LRB- FABP -RRB- 3 ligands .
8760114	3	fatty_acid	399,409	FABP	560,564	fatty acid	FABP	CHEBI:35366	25721(Tax:10116)	Chemical	Gene	analogue|amod|START_ENTITY diffusion|nmod|analogue -LSB-|nsubj|diffusion showed|ccomp|-LSB- showed|parataxis|paralleling paralleling|dobj|amounts amounts|nmod|END_ENTITY	Previously , we showed that the cytoplasmic diffusion of a fatty_acid analogue -LSB- 12-N-methyl-7-nitrobenzo-2-oxa-1 ,3 - diazol-amino_stearate -LRB- NBD-stearate -RRB- -RSB- is faster in female hepatocytes , paralleling the larger amounts of FABP .
23318274	0	fatty_acid	16,26	FABP1	44,49	fatty acid	FABP1	CHEBI:35366	2806	Chemical	Gene	START_ENTITY|dobj|protein protein|appos|END_ENTITY	The human liver fatty_acid binding protein -LRB- FABP1 -RRB- gene is activated by FOXA1 and PPARa ; and repressed by C/EBPa : Implications in FABP1 down-regulation in nonalcoholic_fatty_liver_disease .
24875102	0	fatty_acid	33,43	FABP1	6,11	fatty acid	FABP1	CHEBI:35366	2806	Chemical	Gene	START_ENTITY|nsubj|impacts impacts|compound|END_ENTITY	Human FABP1 T94A variant impacts fatty_acid metabolism and PPAR-a activation in cultured human female hepatocytes .
26443794	0	fatty_acid	55,65	FABP1	83,88	fatty acid	FABP1	CHEBI:35366	2168	Chemical	Gene	START_ENTITY|ccomp|-RSB- -RSB-|nsubj|END_ENTITY	Recent insights into the biological functions of liver fatty_acid binding protein -LSB- FABP1 -RSB- .
15776585	0	fatty_acid	91,101	FABP2	121,126	fatty acid	FABP2	CHEBI:35366	2169	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	-LSB- Genetic polymorphism of pyruvate_dehydrogenase_kinase_4 -LRB- PDK4 -RRB- , paraoxonase_2 -LRB- PON2 -RRB- , and fatty_acid binding protein 2 -LRB- FABP2 -RRB- in the NIDDM population of Senegal -RSB- .
17211557	0	fatty_acid	32,42	FABP2	62,67	fatty acid	FABP2	CHEBI:35366	2169	Chemical	Gene	polymorphism|amod|START_ENTITY polymorphism|compound|END_ENTITY	Lack of association between the fatty_acid binding protein 2 -LRB- FABP2 -RRB- polymorphism with obesity and insulin resistance in two aboriginal populations from Chile .
18440731	0	fatty_acid	34,44	FABP2	64,69	fatty acid	FABP2	CHEBI:35366	2169	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Transcriptional regulation of the fatty_acid binding protein 2 -LRB- FABP2 -RRB- gene by the hepatic nuclear factor 1 alpha -LRB- HNF-1alpha -RRB- .
19207930	0	fatty_acid	44,54	FABP2	14,19	fatty acid	FABP2	CHEBI:35366	2169	Chemical	Gene	composition|amod|START_ENTITY gene|nmod|composition END_ENTITY|nmod|gene	Evaluation of FABP2 as candidate gene for a fatty_acid composition QTL in porcine chromosome 8 .
24340071	0	fatty_acid	102,112	FABP2	39,44	fatty acid	FABP2	CHEBI:35366	2169	Chemical	Gene	concentrations|amod|START_ENTITY associations|nmod|concentrations polymorphism|dep|associations polymorphism|compound|END_ENTITY	Ala54Thr fatty_acid-binding protein 2 -LRB- FABP2 -RRB- polymorphism in recurrent depression : associations with fatty_acid concentrations and waist circumference .
26238699	0	fatty_acid	4,14	FABP2	34,39	fatty acid	FABP2	CHEBI:35366	2169	Chemical	Gene	protein|amod|START_ENTITY protein|dep|2 2|appos|END_ENTITY	The fatty_acid binding protein 2 -LRB- FABP2 -RRB- polymorphism Ala54Thr and obesity in Pakistan : A population based study and a systematic meta-analysis .
26894500	0	fatty_acid	34,44	FABP3	64,69	fatty acid	FABP3	CHEBI:35366	102394447	Chemical	Gene	binding|amod|START_ENTITY gene|amod|binding gene|appos|END_ENTITY	Identification of polymorphism in fatty_acid binding protein 3 -LRB- FABP3 -RRB- gene and its association with milk fat traits in riverine buffalo -LRB- Bubalus_bubalis -RRB- .
17425064	0	fatty_acid	59,69	FABP4	92,97	fatty acid	FABP4	CHEBI:35366	2167	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of a functional polymorphism at the adipose fatty_acid binding protein gene -LRB- FABP4 -RRB- and demonstration of its association with cardiovascular_disease : a path to follow .
17983623	0	fatty_acid	4,14	FABP4	34,39	fatty acid	FABP4	CHEBI:35366	2167	Chemical	Gene	protein-4|amod|START_ENTITY protein-4|appos|END_ENTITY	The fatty_acid binding protein-4 -LRB- FABP4 -RRB- is a strong biomarker of metabolic_syndrome and lipodystrophy in HIV-infected patients .
19077218	0	fatty_acid	20,30	FABP4	61,66	fatty acid	FABP4	CHEBI:35366	281759(Tax:9913)	Chemical	Gene	compositions|amod|START_ENTITY Association|nmod|compositions Association|nmod|END_ENTITY	Association between fatty_acid compositions and genotypes of FABP4 and LXR-alpha in Japanese black cattle .
22188744	0	fatty_acid	15,25	FABP4	45,50	fatty acid	FABP4	CHEBI:35366	2167	Chemical	Gene	START_ENTITY|dobj|protein protein|appos|END_ENTITY	Maternal serum fatty_acid binding protein 4 -LRB- FABP4 -RRB- and the development of preeclampsia .
24024500	0	fatty_acid	45,55	FABP4	73,78	fatty acid	FABP4	CHEBI:35366	2167	Chemical	Gene	START_ENTITY|dobj|protein protein|appos|END_ENTITY	Small molecule inhibitors of human adipocyte fatty_acid binding protein -LRB- FABP4 -RRB- .
24043587	0	fatty_acid	51,61	FABP4	7,12	fatty acid	FABP4	CHEBI:35366	2167	Chemical	Gene	protein|amod|START_ENTITY variants|nmod|protein END_ENTITY|dep|variants	Common FABP4 genetic variants and plasma levels of fatty_acid binding protein 4 in older adults .
25461324	0	fatty_acid	6,16	FABP4	36,41	fatty acid	FABP4	CHEBI:35366	11770(Tax:10090)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Novel fatty_acid binding protein 4 -LRB- FABP4 -RRB- inhibitors : Virtual screening , synthesis and crystal structure determination .
26172243	0	fatty_acid	87,97	FABP4	72,77	fatty acid	FABP4	CHEBI:35366	399533(Tax:9823)	Chemical	Gene	composition|amod|START_ENTITY genes|nmod|composition genes|nummod|END_ENTITY	Effects of genetic variants for the swine FABP3 , HMGA1 , MC4R , IGF2 , and FABP4 genes on fatty_acid composition .
26310911	0	fatty_acid	57,67	FABP4	0,5	fatty acid	FABP4	CHEBI:35366	11770(Tax:10090)	Chemical	Gene	oxidation|amod|START_ENTITY reversed|nmod|oxidation reversed|nsubj|END_ENTITY	FABP4 reversed the regulation of leptin on mitochondrial fatty_acid oxidation in mice adipocytes .
23624787	4	fatty_acid	473,483	FABP5	503,508	fatty acid	FABP5	CHEBI:35366	2171	Chemical	Gene	binding|amod|START_ENTITY protein|amod|binding protein|appos|END_ENTITY	We have previously shown that the fatty_acid binding protein 5 -LRB- FABP5 -RRB- has anti-inflammatory properties .
19744871	0	fatty_acid	52,62	FABP6	80,85	fatty acid	FABP6	CHEBI:35366	2172	Chemical	Gene	START_ENTITY|dobj|protein protein|appos|END_ENTITY	Evidence for the Thr79Met polymorphism of the ileal fatty_acid binding protein -LRB- FABP6 -RRB- to be associated with type 2 diabetes in obese individuals .
18826602	0	fatty_acid	4,14	FABP7	34,39	fatty acid	FABP7	CHEBI:35366	2173	Chemical	Gene	binding|amod|START_ENTITY protein|amod|binding protein|appos|END_ENTITY	The fatty_acid binding protein 7 -LRB- FABP7 -RRB- is involved in proliferation and invasion of melanoma cells .
23284888	0	fatty_acid	27,37	FABP7	57,62	fatty acid	FABP7	CHEBI:35366	2173	Chemical	Gene	protein|amod|START_ENTITY protein|dep|7 7|appos|END_ENTITY	A radial glia gene marker , fatty_acid binding protein 7 -LRB- FABP7 -RRB- , is involved in proliferation and invasion of glioblastoma cells .
14694205	0	fatty_acid	38,48	FABPpm	66,72	fatty acid	FABPpm	CHEBI:35366	2806	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Overexpression of membrane-associated fatty_acid binding protein -LRB- FABPpm -RRB- in vivo increases fatty_acid sarcolemmal transport and metabolism .
14694205	0	fatty_acid	92,102	FABPpm	66,72	fatty acid	FABPpm	CHEBI:35366	2806	Chemical	Gene	START_ENTITY|nsubj|Overexpression Overexpression|nmod|protein protein|appos|END_ENTITY	Overexpression of membrane-associated fatty_acid binding protein -LRB- FABPpm -RRB- in vivo increases fatty_acid sarcolemmal transport and metabolism .
19380575	0	fatty_acid	47,57	FABPpm	104,110	fatty acid	FABPpm	CHEBI:35366	25721(Tax:10116)	Chemical	Gene	efficiencies|nmod|START_ENTITY transporters|nsubj|efficiencies transporters|dobj|FAT/CD36 FAT/CD36|nmod|END_ENTITY	Greater transport efficiencies of the membrane fatty_acid transporters FAT/CD36 and FATP4 compared with FABPpm and FATP1 and differential effects on fatty_acid esterification and oxidation in rat skeletal muscle .
19527715	0	fatty_acid	54,64	FABPpm	114,120	fatty acid	FABPpm	CHEBI:35366	2806	Chemical	Gene	transport|amod|START_ENTITY transport|appos|_ _|appos|END_ENTITY	Additive effects of insulin and muscle contraction on fatty_acid transport and fatty_acid transporters , FAT/CD36 , FABPpm , FATP1 , _ 4_and_6 .
9070301	0	fatty_acid	20,30	FABPpm	48,54	fatty acid	FABPpm	CHEBI:35366	2806	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Membrane associated fatty_acid binding protein -LRB- FABPpm -RRB- in human skeletal muscle is increased by endurance training .
22279586	0	fatty_acid	12,22	FAD2	34,38	fatty acid	FAD2	CHEBI:35366	820387(Tax:3702)	Chemical	Gene	START_ENTITY|ccomp|required required|nsubjpass|END_ENTITY	Arabidopsis fatty_acid desaturase FAD2 is required for salt tolerance during seed germination and early seedling growth .
19776639	0	fatty_acid	57,67	FADS	0,4	fatty acid	FADS	CHEBI:35366	4593	Chemical	Gene	levels|amod|START_ENTITY modulators|nmod|levels polymorphisms|dep|modulators polymorphisms|compound|END_ENTITY	FADS gene cluster polymorphisms : important modulators of fatty_acid levels and their impact on atopic_diseases .
19948371	0	fatty_acid	46,56	FADS	3,7	fatty acid	FADS	CHEBI:35366	4593	Chemical	Gene	phenotypes|amod|START_ENTITY enhance|nmod|phenotypes enhance|nsubj|genotypes genotypes|compound|END_ENTITY	Do FADS genotypes enhance our knowledge about fatty_acid related phenotypes ?
20427696	0	fatty_acid	138,148	FADS	39,43	fatty acid	FADS	CHEBI:35366	5913	Chemical	Gene	ratios|amod|START_ENTITY estimated|nmod|ratios activities|acl|estimated associated|nmod|activities associated|nsubjpass|polymorphisms polymorphisms|nmod|cluster cluster|compound|END_ENTITY	Single nucleotide polymorphisms in the FADS gene cluster are associated with delta-5 and delta-6_desaturase activities estimated by serum fatty_acid ratios .
21733300	0	fatty_acid	43,53	FADS	66,70	fatty acid	FADS	CHEBI:35366	6319	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Differences in arachidonic_acid levels and fatty_acid desaturase -LRB- FADS -RRB- gene variants in African Americans and European Americans with diabetes_or_the_metabolic_syndrome .
21793953	0	fatty_acid	50,60	FADS	0,4	fatty acid	FADS	CHEBI:35366	80308	Chemical	Gene	intake|amod|START_ENTITY effect|nmod|intake modulate|dobj|effect modulate|nsubj|variants variants|compound|END_ENTITY	FADS gene variants modulate the effect of dietary fatty_acid intake on allergic_diseases in children .
21818279	0	fatty_acid	73,83	FADS	13,17	fatty acid	FADS	CHEBI:35366	4593	Chemical	Gene	concentrations|amod|START_ENTITY tracking|nmod|concentrations polymorphisms|advcl|tracking polymorphisms|nsubj|Influence Influence|nmod|END_ENTITY	Influence of FADS polymorphisms on tracking of serum glycerophospholipid fatty_acid concentrations and percentage composition in children .
24075244	0	fatty_acid	65,75	FADS	88,92	fatty acid	FADS	CHEBI:35366	6319	Chemical	Gene	arachidonic_acid|dep|START_ENTITY arachidonic_acid|nsubj|desaturase desaturase|appos|END_ENTITY	Dietary arachidonic_acid and docosahexaenoic_acid regulate liver fatty_acid desaturase -LRB- FADS -RRB- alternative transcript expression in suckling piglets .
24962583	0	fatty_acid	45,55	FADS	68,72	fatty acid	FADS	CHEBI:35366	6319	Chemical	Gene	desaturase|amod|START_ENTITY desaturase|appos|END_ENTITY	Relationship between a common variant in the fatty_acid desaturase -LRB- FADS -RRB- cluster and eicosanoid generation in humans .
23273446	0	fatty_acid	84,94	FADS1	67,72	fatty acid	FADS1	CHEBI:35366	533107(Tax:9913)	Chemical	Gene	composition|amod|START_ENTITY genes|nmod|composition genes|nummod|END_ENTITY	Association analyses of DNA polymorphisms in bovine SREBP-1 , LXRa , FADS1 genes with fatty_acid composition in Canadian commercial crossbred beef steers .
11015476	0	fatty_acid	53,63	FAS	74,77	fatty acid	FAS	CHEBI:35366	2194	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	Relationship between human adipose tissue agouti and fatty_acid synthase -LRB- FAS -RRB- .
12652618	0	fatty_acid	35,45	FAS	56,59	fatty acid	FAS	CHEBI:35366	2194	Chemical	Gene	START_ENTITY|dobj|synthase synthase|appos|END_ENTITY	Expression of the lipogenic enzyme fatty_acid synthase -LRB- FAS -RRB- as a predictor of poor outcome in nephroblastoma : an interinstitutional study .
1339331	0	fatty_acid	4,14	FAS	25,28	fatty acid	FAS	CHEBI:35366	50671(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	The fatty_acid synthase -LRB- FAS -RRB- gene and its promoter in Rattus_norvegicus .
15220220	0	fatty_acid	50,60	FAS	76,79	fatty acid	FAS	CHEBI:35366	2194	Chemical	Gene	synthase|amod|START_ENTITY gene|amod|synthase gene|appos|END_ENTITY	A novel missense substitution -LRB- Val1483Ile -RRB- in the fatty_acid synthase gene -LRB- FAS -RRB- is associated with percentage of body fat and substrate oxidation rates in nondiabetic Pima Indians .
18528705	0	fatty_acid	27,37	FAS	48,51	fatty acid	FAS	CHEBI:35366	2194	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	Differential expression of fatty_acid synthase -LRB- FAS -RRB- and ErbB2 in nonmalignant and malignant oral keratinocytes .
21389266	0	fatty_acid	56,66	FAS	77,80	fatty acid	FAS	CHEBI:35366	14104(Tax:10090)	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	Antidiabetic and antisteatotic effects of the selective fatty_acid synthase -LRB- FAS -RRB- inhibitor platensimycin in mouse models of diabetes .
21717057	0	fatty_acid	29,39	FAS	50,53	fatty acid	FAS	CHEBI:35366	396061(Tax:9031)	Chemical	Gene	synthase|advmod|START_ENTITY synthase|dep|END_ENTITY	Liver dominant expression of fatty_acid synthase -LRB- FAS -RRB- gene in two chicken breeds during intramuscular-fat development .
21752639	0	fatty_acid	19,29	FAS	40,43	fatty acid	FAS	CHEBI:35366	2194	Chemical	Gene	START_ENTITY|dobj|inhibitors inhibitors|appos|END_ENTITY	Discovery of novel fatty_acid synthase -LRB- FAS -RRB- inhibitors based on the structure of ketoaceyl synthase -LRB- KS -RRB- domain .
22338595	0	fatty_acid	28,38	FAS	49,52	fatty acid	FAS	CHEBI:35366	2194	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	Anti-cancer drugs targeting fatty_acid synthase -LRB- FAS -RRB- .
23142364	0	fatty_acid	14,24	FAS	35,38	fatty acid	FAS	CHEBI:35366	2194	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	Regulation of fatty_acid synthase -LRB- FAS -RRB- and apoptosis in estrogen-receptor positive and negative breast_cancer cells by conjugated linoleic_acids .
23419663	0	fatty_acid	21,31	FAS	42,45	fatty acid	FAS	CHEBI:35366	2194	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	Expression status of fatty_acid synthase -LRB- FAS -RRB- but not HER2 is correlated with the differentiation grade and prognosis of esophageal_carcinoma .
25050832	4	fatty_acid	908,918	FAS	929,932	fatty acid	FAS	CHEBI:35366	14104(Tax:10090)	Chemical	Gene	synthase|advmod|START_ENTITY synthase|dep|END_ENTITY	These effects were accompanied by a decreased expression of lipogenic genes , including sterol regulatory element binding protein-1c , liver X receptor , fatty_acid synthase -LRB- FAS -RRB- , acetyl - CoA carboxylase , cluster of differentiation 36 , lipoprotein lipase and decreased lipogenic enzyme FAS and 3-hydroxy-3_methylglutamyl coenzyme reductase enzyme activities , while elevating carnitine palmitoyltrasferase-1 activity .
25761671	0	fatty_acid	21,31	FAS	42,45	fatty acid	FAS	CHEBI:35366	2194	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	Cryo-EM structure of fatty_acid synthase -LRB- FAS -RRB- from Rhodosporidium toruloides provides insights into the evolutionary development of fungal_FAS .
7810643	1	fatty_acid	217,227	FAS	238,241	fatty acid	LPL	CHEBI:35366	24539(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	The effects of a fish oil concentrate on blood lipids and lipoproteins were examined in relation to their effects on liver fatty_acid synthase -LRB- FAS -RRB- , 3-hydroxy-3-methylglutaryl-CoA -LRB- HMG-CoA -RRB- _ reductase , adipose tissue lipoprotein lipase -LRB- LPL -RRB- , and hepatic triglyceride lipase -LRB- H-TGL -RRB- .
8039704	0	fatty_acid	60,70	FAS	81,84	fatty acid	FAS	CHEBI:35366	50671(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|regulation regulation|amod|synthase synthase|dep|END_ENTITY	The tripartite DNA element responsible for diet-induced rat fatty_acid synthase -LRB- FAS -RRB- regulation .
9016948	0	fatty_acid	100,110	FAS	121,124	fatty acid	FAS	CHEBI:35366	50671(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|gene gene|amod|synthase synthase|dep|END_ENTITY	NF-Y binds to the inverted CCAAT box , an essential element for cAMP-dependent regulation of the rat fatty_acid synthase -LRB- FAS -RRB- gene .
11571758	0	fatty_acid	13,23	FAS1	43,47	fatty acid	FAS1	CHEBI:35366	853653(Tax:4932)	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Cloning of a fatty_acid synthase component FAS1 gene from Saccharomyces_kluyveri and its functional complementation of S. _ cerevisiae fas1 mutant .
11713312	0	fatty_acid	114,124	FAS1	151,155	fatty acid	FAS1	CHEBI:35366	853653(Tax:4932)	Chemical	Gene	START_ENTITY|nmod|product product|compound|END_ENTITY	A downstream regulatory element located within the coding sequence mediates autoregulated expression of the yeast fatty_acid synthase gene FAS2 by the FAS1 gene product .
1552898	0	fatty_acid	43,53	FAS1	209,213	fatty acid	FAS1	CHEBI:35366	853653(Tax:4932)	Chemical	Gene	gene|amod|START_ENTITY structure|nmod|gene consistent|nsubj|structure consistent|dep|END_ENTITY	Molecular structure of the multifunctional fatty_acid synthetase gene of Brevibacterium_ammoniagenes : its sequence of catalytic domains is formally consistent with a head-to-tail fusion of the two yeast genes FAS1 and FAS2 .
3031066	0	fatty_acid	97,107	FAS1	56,60	fatty acid	FAS1	CHEBI:35366	853653(Tax:4932)	Chemical	Gene	START_ENTITY|nsubj|Complementation Complementation|nmod|gene gene|nummod|END_ENTITY	Complementation of mutations and nucleotide sequence of FAS1 gene encoding beta subunit of yeast fatty_acid synthase .
6330502	0	fatty_acid	31,41	FAS1	109,113	fatty acid	FAS1	CHEBI:35366	853653(Tax:4932)	Chemical	Gene	START_ENTITY|advcl|illustrating illustrating|dobj|structure structure|nmod|gene gene|compound|END_ENTITY	Molecular cloning of the yeast fatty_acid synthetase genes , FAS1 and FAS2 : illustrating the structure of the FAS1 cluster gene by transcript mapping and transformation studies .
6330502	0	fatty_acid	31,41	FAS1	60,64	fatty acid	FAS1	CHEBI:35366	853653(Tax:4932)	Chemical	Gene	START_ENTITY|advcl|illustrating illustrating|nsubj|END_ENTITY	Molecular cloning of the yeast fatty_acid synthetase genes , FAS1 and FAS2 : illustrating the structure of the FAS1 cluster gene by transcript mapping and transformation studies .
16479401	0	fatty_acid	45,55	FAS2	75,79	fatty acid	FAS2	CHEBI:35366	855845(Tax:4932)	Chemical	Gene	component|amod|START_ENTITY characterization|nmod|component END_ENTITY|nsubj|characterization	Cloning and functional characterization of a fatty_acid synthase component FAS2 gene from Saccharomyces_kluyveri .
2900835	0	fatty_acid	72,82	FAS2	105,109	fatty acid	FAS2	CHEBI:35366	855845(Tax:4932)	Chemical	Gene	START_ENTITY|dobj|synthase synthase|acl|derived derived|nmod|sequence sequence|compound|END_ENTITY	Primary structure of the multifunctional alpha subunit protein of yeast fatty_acid synthase derived from FAS2 gene sequence .
3053172	0	fatty_acid	39,49	FAS2	61,65	fatty acid	FAS2	CHEBI:35366	855845(Tax:4932)	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Isolation and sequence analysis of the fatty_acid synthetase FAS2 gene from Penicillium patulum .
11014573	0	fatty_acid	18,28	FASE	39,43	fatty acid	FASE	CHEBI:35366	2194	Chemical	Gene	synthase|amod|START_ENTITY expression|nmod|synthase expression|appos|END_ENTITY	The expression of fatty_acid synthase -LRB- FASE -RRB- is an early event in the development and progression of squamous_cell_carcinoma_of_the_lung .
15926258	0	fatty_acid	95,105	FASN	116,120	fatty acid	FASN	CHEBI:35366	281152(Tax:9913)	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	Radiation hybrid and genetic linkage mapping of two genes related to fat metabolism in cattle : fatty_acid synthase -LRB- FASN -RRB- and glycerol-3-phosphate_acyltransferase_mitochondrial -LRB- GPAM -RRB- .
16093723	0	fatty_acid	55,65	FASN	116,120	fatty acid	FASN	CHEBI:35366	281152(Tax:9913)	Chemical	Gene	gene|amod|START_ENTITY structure|nmod|gene structure|dep|analysis analysis|nmod|gene gene|compound|END_ENTITY	Genomic structure and alternative transcript of bovine fatty_acid synthase gene -LRB- FASN -RRB- : comparative analysis of the FASN gene between monogastric and ruminant species .
16093723	0	fatty_acid	55,65	FASN	81,85	fatty acid	FASN	CHEBI:35366	281152(Tax:9913)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic structure and alternative transcript of bovine fatty_acid synthase gene -LRB- FASN -RRB- : comparative analysis of the FASN gene between monogastric and ruminant species .
17168665	0	fatty_acid	79,89	FASN	51,55	fatty acid	FASN	CHEBI:35366	2194	Chemical	Gene	biogenesis|amod|START_ENTITY endogenous|dep|biogenesis inhibitors|dep|endogenous inhibitors|nmod|Fatty_Acid_Synthase Fatty_Acid_Synthase|appos|END_ENTITY	Pharmacological inhibitors of Fatty_Acid_Synthase -LRB- FASN -RRB- -- catalyzed endogenous fatty_acid biogenesis : a new family of anti-cancer agents ?
17313375	0	fatty_acid	42,52	FASN	63,67	fatty acid	FASN	CHEBI:35366	2194	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	Polyunsaturated fatty_acid suppression of fatty_acid synthase -LRB- FASN -RRB- : evidence for dietary modulation of NF-Y binding to the Fasn promoter by SREBP-1c .
19291389	0	fatty_acid	53,63	FASN	23,27	fatty acid	FASN	CHEBI:35366	281152(Tax:9913)	Chemical	Gene	composition|amod|START_ENTITY mutations|nmod|composition mutations|nmod|gene gene|compound|END_ENTITY	Novel mutations of the FASN gene and their effect on fatty_acid composition in Japanese Black beef .
19362044	0	fatty_acid	76,86	FASN	97,101	fatty acid	FASN	CHEBI:35366	2194	Chemical	Gene	START_ENTITY|dobj|synthase synthase|appos|END_ENTITY	Clinicopathological significance of ubiquitin-specific protease 2a -LRB- USP2a -RRB- , fatty_acid synthase -LRB- FASN -RRB- , and ErbB2 expression in oral_squamous_cell_carcinomas .
19876008	0	fatty_acid	41,51	FASN	67,71	fatty acid	FASN	CHEBI:35366	2194	Chemical	Gene	gene|amod|START_ENTITY variation|nmod|gene Effect|nmod|variation Effect|appos|END_ENTITY	Effect of genetic variation in the human fatty_acid synthase gene -LRB- FASN -RRB- on obesity and fat depot-specific mRNA expression .
21819495	0	fatty_acid	14,24	FASN	35,39	fatty acid	FASN	CHEBI:35366	2194	Chemical	Gene	synthase|amod|START_ENTITY Expression|nmod|synthase Expression|appos|END_ENTITY	Expression of fatty_acid synthase -LRB- FASN -RRB- in oral nevi and melanoma .
22497525	0	fatty_acid	52,62	FASN	17,21	fatty acid	FASN	CHEBI:35366	281152(Tax:9913)	Chemical	Gene	composition|amod|START_ENTITY Contributions|nmod|composition Contributions|nmod|polymorphisms polymorphisms|compound|END_ENTITY	Contributions of FASN and SCD gene polymorphisms on fatty_acid composition in muscle from Japanese Black cattle .
23181152	2	fatty_acid	258,268	FASN	279,283	fatty acid	FASN	CHEBI:35366	2194	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	The ocular_cancer , retinoblastoma cells were treated with fatty_acid synthase -LRB- FASN -RRB- enzyme inhibitors : cerulenin , triclosan and orlistat .
23403305	0	fatty_acid	45,55	FASN	21,25	fatty acid	FASN	CHEBI:35366	281152(Tax:9913)	Chemical	Gene	composition|amod|START_ENTITY associated|nmod|composition associated|nsubjpass|variation variation|nmod|END_ENTITY	Genetic variation of FASN is associated with fatty_acid composition of Hanwoo .
24080588	0	fatty_acid	24,34	FASN	45,49	fatty acid	FASN	CHEBI:35366	2194	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	Molecular mechanisms of fatty_acid synthase -LRB- FASN -RRB- - mediated resistance to anti-cancer treatments .
24413995	0	fatty_acid	26,36	FASN	47,51	fatty acid	FASN	CHEBI:35366	281152(Tax:9913)	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	Gene-gene interactions of fatty_acid synthase -LRB- FASN -RRB- using multifactor-dimensionality reduction method in Korean cattle .
25597874	0	fatty_acid	49,59	FASN	20,24	fatty acid	FASN	CHEBI:35366	281152(Tax:9913)	Chemical	Gene	composition|amod|START_ENTITY associated|nmod|composition associated|nsubjpass|SNP SNP|nmod|gene gene|compound|END_ENTITY	The g. 841G > C SNP of FASN gene is associated with fatty_acid composition in beef cattle .
26376068	0	fatty_acid	38,48	FASN	59,63	fatty acid	FASN	CHEBI:35366	281152(Tax:9913)	Chemical	Gene	START_ENTITY|dobj|gene gene|appos|END_ENTITY	Genetic diversity analysis of buffalo fatty_acid synthase -LRB- FASN -RRB- gene and its differential expression among bovines .
12054519	0	fatty_acid	4,14	FAT	28,31	fatty acid	FAT	CHEBI:35366	29184(Tax:10116)	Chemical	Gene	translocase|amod|START_ENTITY translocase|appos|END_ENTITY	The fatty_acid translocase -LRB- FAT -RRB- / CD36 and the glucose transporter GLUT4 are localized in different cellular compartments in rat cardiac muscle .
12479585	0	fatty_acid	47,57	FAT	71,74	fatty acid	FAT	CHEBI:35366	948	Chemical	Gene	translocase|amod|START_ENTITY translocase|appos|END_ENTITY	The impact of overexpression and deficiency of fatty_acid translocase -LRB- FAT -RRB- / CD36 .
14740222	0	fatty_acid	34,44	FAT	58,61	fatty acid	FAT	CHEBI:35366	948	Chemical	Gene	translocase|amod|START_ENTITY translocase|appos|END_ENTITY	Subcellular immunolocalisation of fatty_acid translocase -LRB- FAT -RRB- / CD36 in human type-1 and type-2 skeletal muscle fibres .
15161924	0	fatty_acid	21,31	FAT	45,48	fatty acid	FAT	CHEBI:35366	948	Chemical	Gene	translocase|amod|START_ENTITY translocase|appos|END_ENTITY	A novel function for fatty_acid translocase -LRB- FAT -RRB- / CD36 : involvement in long chain fatty_acid transfer into the mitochondria .
15161924	0	fatty_acid	82,92	FAT	45,48	fatty acid	FAT	CHEBI:35366	948	Chemical	Gene	CD36|parataxis|START_ENTITY CD36|dep|function function|nmod|translocase translocase|appos|END_ENTITY	A novel function for fatty_acid translocase -LRB- FAT -RRB- / CD36 : involvement in long chain fatty_acid transfer into the mitochondria .
9315741	0	fatty_acid	36,46	FAT	60,63	fatty acid	FAT	CHEBI:35366	29184(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|transporter transporter|appos|END_ENTITY	Expression of the putative membrane fatty_acid transporter -LRB- FAT -RRB- in taste buds of the circumvallate papillae in rats .
12479588	0	fatty_acid	75,85	FAT/CD36	99,107	fatty acid	FAT/CD36	CHEBI:35366	29184(Tax:10116)	Chemical	Gene	translocase|amod|START_ENTITY translocase|appos|END_ENTITY	Sulfo-N-succinimidyl_esters of long chain fatty_acids specifically inhibit fatty_acid translocase -LRB- FAT/CD36 -RRB- - mediated cellular fatty_acid uptake .
16541201	0	fatty_acid	86,96	FAT/CD36	110,118	fatty acid	FAT/CD36	CHEBI:35366	29184(Tax:10116)	Chemical	Gene	translocase|amod|START_ENTITY translocase|appos|END_ENTITY	Purification , immunochemical quantification and localization in rat heart of putative fatty_acid translocase -LRB- FAT/CD36 -RRB- .
18238811	0	fatty_acid	49,59	FAT/CD36	73,81	fatty acid	FAT/CD36	CHEBI:35366	29184(Tax:10116)	Chemical	Gene	translocase|amod|START_ENTITY translocase|appos|END_ENTITY	Rosiglitazone increases fatty_acid oxidation and fatty_acid translocase -LRB- FAT/CD36 -RRB- but not carnitine_palmitoyltransferase_I in rat muscle mitochondria .
22700514	0	fatty_acid	64,74	FAT/CD36	88,96	fatty acid	FAT/CD36	CHEBI:35366	102085465	Chemical	Gene	translocase|amod|START_ENTITY translocase|appos|END_ENTITY	Molecular cloning , characterization , and expression analysis of fatty_acid translocase -LRB- FAT/CD36 -RRB- in the pigeon -LRB- Columba_livia_domestica -RRB- .
15522816	0	fatty_acid	33,43	FATP	8,12	fatty acid	FATP	CHEBI:35366	376497	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of FATP in parenchymal cell fatty_acid uptake .
15699031	0	fatty_acid	46,56	FATP	77,81	fatty acid	FATP	CHEBI:35366	26457(Tax:10090)	Chemical	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	Comparative biochemical studies of the murine fatty_acid transport proteins -LRB- FATP -RRB- expressed in yeast .
17901542	0	fatty_acid	4,14	FATP	34,38	fatty acid	FATP	CHEBI:35366	26457(Tax:10090)	Chemical	Gene	family|amod|START_ENTITY family|appos|END_ENTITY	The fatty_acid transport protein -LRB- FATP -RRB- family : very long chain acyl-CoA synthetases or solute carriers ?
20875854	0	fatty_acid	45,55	FATP	75,79	fatty acid	FATP	CHEBI:35366	100174941(Tax:7091)	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Cloning and functional characterization of a fatty_acid transport protein -LRB- FATP -RRB- from the pheromone gland of a lichen moth , Eilema_japonica , which secretes an alkenyl sex pheromone .
26635907	0	fatty_acid	14,24	FATP	45,49	fatty acid	FATP	CHEBI:35366	376497	Chemical	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	Targeting the fatty_acid transport proteins -LRB- FATP -RRB- to understand the mechanisms linking fatty_acid transport to metabolism .
26635907	0	fatty_acid	88,98	FATP	45,49	fatty acid	FATP	CHEBI:35366	376497	Chemical	Gene	transport|amod|START_ENTITY linking|dobj|transport understand|dep|linking Targeting|advcl|understand Targeting|dobj|proteins proteins|appos|END_ENTITY	Targeting the fatty_acid transport proteins -LRB- FATP -RRB- to understand the mechanisms linking fatty_acid transport to metabolism .
10593920	0	fatty_acid	4,14	FATP1	34,39	fatty acid	FATP1	CHEBI:35366	376497	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	The fatty_acid transport protein -LRB- FATP1 -RRB- is a very_long_chain_acyl-CoA_synthetase .
15897321	0	fatty_acid	10,20	FATP1	65,70	fatty acid	FATP1	CHEBI:35366	376497	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|nmod|proteins proteins|compound|END_ENTITY	Impact on fatty_acid metabolism and differential localization of FATP1 and FAT/CD36 proteins delivered in cultured human muscle cells .
16611988	0	fatty_acid	30,40	FATP1	0,5	fatty acid	FATP1	CHEBI:35366	376497	Chemical	Gene	transporter|amod|START_ENTITY transporter|nsubj|END_ENTITY	FATP1 is an insulin-sensitive fatty_acid transporter involved in diet-induced obesity .
19429947	0	fatty_acid	37,47	FATP1	14,19	fatty acid	FATP1	CHEBI:35366	94172(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	Novel role of FATP1 in mitochondrial fatty_acid oxidation in skeletal muscle cells .
21442160	0	fatty_acid	27,37	FATP1	59,64	fatty acid	FATP1	CHEBI:35366	26457(Tax:10090)	Chemical	Gene	muscle|acl|START_ENTITY muscle|appos|END_ENTITY	Increasing skeletal muscle fatty_acid transport protein 1 -LRB- FATP1 -RRB- targets fatty_acids to oxidation and does not predispose mice to diet-induced insulin resistance .
22749869	0	fatty_acid	36,46	FATP1	68,73	fatty acid	FATP1	CHEBI:35366	376497	Chemical	Gene	START_ENTITY|dobj|protein protein|acl:relcl|inhibitors inhibitors|nsubj|1 1|appos|END_ENTITY	Discovery and optimization of novel fatty_acid transport protein 1 -LRB- FATP1 -RRB- inhibitors .
23024797	0	fatty_acid	66,76	FATP1	14,19	fatty acid	FATP1	CHEBI:35366	376497	Chemical	Gene	uptake|amod|START_ENTITY increase|dobj|uptake increase|nsubj|END_ENTITY	Overexpressed FATP1 , ACSVL4/FATP4 and ACSL1 increase the cellular fatty_acid uptake of 3T3-L1 adipocytes but are localized on intracellular membranes .
23528296	0	fatty_acid	19,29	FATP1	51,56	fatty acid	FATP1	CHEBI:35366	376497	Chemical	Gene	protein|amod|START_ENTITY Arylpiperazines|nmod|protein Arylpiperazines|appos|END_ENTITY	Arylpiperazines as fatty_acid transport protein 1 -LRB- FATP1 -RRB- inhibitors with improved potency and pharmacokinetic properties .
20530735	0	fatty_acid	19,29	FATP2	0,5	fatty acid	FATP2	CHEBI:35366	11001	Chemical	Gene	transporter|amod|START_ENTITY transporter|nsubj|END_ENTITY	FATP2 is a hepatic fatty_acid transporter and peroxisomal very_long-chain_acyl-CoA_synthetase .
22022213	0	fatty_acid	81,91	FATP2	48,53	fatty acid	FATP2	CHEBI:35366	11001	Chemical	Gene	uptake|amod|START_ENTITY increases|dobj|uptake increases|nsubj|Overexpression Overexpression|nmod|FATP4 FATP4|compound|END_ENTITY	Overexpression of CD36 and acyl-CoA synthetases FATP2 , FATP4 and ACSL1 increases fatty_acid uptake in human hepatoma cells .
11404000	0	fatty_acid	6,16	FATP4	38,43	fatty acid	FATP4	CHEBI:35366	26569(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|protein protein|dep|4 4|appos|END_ENTITY	Mouse fatty_acid transport protein 4 -LRB- FATP4 -RRB- : characterization of the gene and functional assessment as a very long chain acyl-CoA synthetase .
15653672	0	fatty_acid	40,50	FATP4	134,139	fatty acid	FATP4	CHEBI:35366	26569(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|tissues tissues|nmod|mice mice|nummod|END_ENTITY	Enzymatic properties of purified murine fatty_acid transport protein 4 and analysis of acyl-CoA synthetase activities in tissues from FATP4 null mice .
20513444	0	fatty_acid	45,55	FATP4	77,82	fatty acid	FATP4	CHEBI:35366	26569(Tax:10090)	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Epidermal hyperproliferation in mice lacking fatty_acid transport protein 4 -LRB- FATP4 -RRB- involves ectopic EGF_receptor and STAT3 signaling .
21750264	0	fatty_acid	65,75	FATP4	0,5	fatty acid	FATP4	CHEBI:35366	26569(Tax:10090)	Chemical	Gene	uptake|amod|START_ENTITY contributes|nmod|uptake contributes|nsubj|END_ENTITY	FATP4 contributes as an enzyme to the basal and insulin-mediated fatty_acid uptake of C C muscle cells .
22022213	0	fatty_acid	81,91	FATP4	55,60	fatty acid	FATP4	CHEBI:35366	10999	Chemical	Gene	uptake|amod|START_ENTITY increases|dobj|uptake increases|nsubj|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of CD36 and acyl-CoA synthetases FATP2 , FATP4 and ACSL1 increases fatty_acid uptake in human hepatoma cells .
12684041	0	fatty_acid	25,35	FFA2R	46,51	fatty acid	FFA2R	CHEBI:35366	2867	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Identification of a free fatty_acid receptor , FFA2R , expressed on leukocytes and activated by short-chain fatty_acids .
17980148	0	fatty_acid	84,94	FFAR1	72,77	fatty acid	FFAR1	CHEBI:35366	2864	Chemical	Gene	receptor|amod|START_ENTITY END_ENTITY|dep|receptor	Production and characterization of a monoclonal antibody against GPR40 -LRB- FFAR1 ; free fatty_acid receptor 1 -RRB- .
18927207	0	fatty_acid	58,68	FFAR1	46,51	fatty acid	FFAR1	CHEBI:35366	2864	Chemical	Gene	receptor|amod|START_ENTITY END_ENTITY|dep|receptor	Flow cytometry-based binding assay for GPR40 -LRB- FFAR1 ; free fatty_acid receptor 1 -RRB- .
25161890	0	fatty_acid	72,82	FFAR1	95,100	fatty acid	FFAR1	CHEBI:35366	2864	Chemical	Gene	secretion|amod|START_ENTITY secretion|compound|END_ENTITY	Peroxisome_proliferator-activated_receptor_gamma -LRB- PPARG -RRB- modulates free fatty_acid receptor 1 -LRB- FFAR1 -RRB- dependent insulin secretion in humans .
24325907	0	fatty_acid	23,33	FFAR3	81,86	fatty acid	FFAR3	CHEBI:35366	2865	Chemical	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Effects of short chain fatty_acid producing bacteria on epigenetic regulation of FFAR3 in type 2 diabetes and obesity .
25754072	0	fatty_acid	4,14	Fabp6	39,44	fatty acid	Fabp6	CHEBI:35366	16204(Tax:10090)	Chemical	Gene	binding|amod|START_ENTITY gene|amod|binding gene|appos|END_ENTITY	The fatty_acid binding protein 6 gene -LRB- Fabp6 -RRB- is expressed in murine granulosa cells and is involved in ovulatory response to superstimulation .
18286188	0	fatty_acid	6,16	Fabp7	34,39	fatty acid	Fabp7	CHEBI:35366	12140(Tax:10090)	Chemical	Gene	START_ENTITY|ccomp|regulated regulated|nsubjpass|protein protein|appos|END_ENTITY	Brain fatty_acid binding protein -LRB- Fabp7 -RRB- is diurnally regulated in astrocytes and hippocampal granule cell precursors in adult rodent brain .
9666100	0	fatty_acid	66,76	Fabpe	99,104	fatty acid	Fabpe	CHEBI:35366	16592(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|gene gene|appos|END_ENTITY	Cloning and chromosomal localisation of the murine epidermal-type fatty_acid binding protein gene -LRB- Fabpe -RRB- .
1527171	0	fatty_acid	68,78	Fabpi	101,106	fatty acid	Fabpi	CHEBI:35366	14079(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|gene gene|appos|END_ENTITY	Use of transgenic_mice to map cis-acting elements in the intestinal fatty_acid binding protein gene -LRB- Fabpi -RRB- that control its cell lineage-specific and regional patterns of expression along the duodenal-colonic and crypt-villus axes of the gut epithelium .
22952445	0	fatty_acid	35,45	Fas2	56,60	fatty acid	Fas2	CHEBI:35366	855845(Tax:4932)	Chemical	Gene	START_ENTITY|ccomp|induces induces|nsubj|synthase synthase|appos|END_ENTITY	Inhibition of Candida_parapsilosis fatty_acid synthase -LRB- Fas2 -RRB- induces mitochondrial cell death in serum .
17313375	0	fatty_acid	42,52	Fasn	125,129	fatty acid	Fasn	CHEBI:35366	2194	Chemical	Gene	synthase|amod|START_ENTITY suppression|nmod|synthase suppression|dep|evidence evidence|nmod|modulation modulation|acl|NF-Y NF-Y|xcomp|binding binding|nmod|promoter promoter|compound|END_ENTITY	Polyunsaturated fatty_acid suppression of fatty_acid synthase -LRB- FASN -RRB- : evidence for dietary modulation of NF-Y binding to the Fasn promoter by SREBP-1c .
9916795	0	fatty_acid	77,87	Fat	24,27	fatty acid	Fat	CHEBI:35366	29184(Tax:10116)	Chemical	Gene	causing|dobj|START_ENTITY Identification|acl|causing Identification|nmod|Cd36 Cd36|appos|END_ENTITY	Identification of Cd36 -LRB- Fat -RRB- as an insulin-resistance gene causing defective fatty_acid and glucose metabolism in hypertensive rats .
12777469	0	fatty_acid	41,51	GLP-1	0,5	fatty acid	GLP-1	CHEBI:35366	24952(Tax:10116)	Chemical	Gene	glucose-derived|ccomp|START_ENTITY glucose-derived|nsubj|stimulates stimulates|compound|END_ENTITY	GLP-1 stimulates glucose-derived de novo fatty_acid synthesis and chain elongation during cell differentiation and insulin release .
18320172	0	fatty_acid	45,55	GLP-1	113,118	fatty acid	GLP-1	CHEBI:35366	24952(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Cloning and characterization of the rat free fatty_acid receptor GPR120 : in vivo effect of the natural ligand on GLP-1 secretion and proliferation of pancreatic beta cells .
23341498	0	fatty_acid	18,28	GLP-1	42,47	fatty acid	GLP-1	CHEBI:35366	14526(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	Gustducin couples fatty_acid receptors to GLP-1 release in colon .
25109781	0	fatty_acid	82,92	GLP-1	49,54	fatty acid	GLP-1	CHEBI:35366	14526(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY END_ENTITY|nmod|receptor	The short chain fatty_acid propionate stimulates GLP-1 and PYY secretion via free fatty_acid receptor 2 in rodents .
26791830	0	fatty_acid	102,112	GLP-1	42,47	fatty acid	GLP-1	CHEBI:35366	24952(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY antagonizing|dobj|receptors blocks|advcl|antagonizing blocks|dobj|secretion secretion|compound|END_ENTITY	Mercaptoacetate blocks fatty_acid-induced GLP-1 secretion in male rats by directly antagonizing GPR40 fatty_acid receptors .
19471906	0	fatty_acid	33,43	GPR120	54,60	fatty acid	GPR120	CHEBI:35366	107221(Tax:10090)	Chemical	Gene	receptors|amod|START_ENTITY ligands|nmod|receptors END_ENTITY|nsubj|ligands	Novel selective ligands for free fatty_acid receptors GPR120 and GPR40 .
19723586	0	fatty_acid	77,87	GPR120	65,71	fatty acid	GPR120	CHEBI:35366	102136156	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Cloning , expression , and pharmacological characterization of the GPR120 free fatty_acid receptor from cynomolgus_monkey : comparison with human GPR120 splice variants .
24239485	0	fatty_acid	69,79	GPR120	56,62	fatty acid	GPR120	CHEBI:35366	338557	Chemical	Gene	receptor|amod|START_ENTITY END_ENTITY|dep|receptor	Free fatty_acids and protein kinase C activation induce GPR120 -LRB- free fatty_acid receptor 4 -RRB- phosphorylation .
25191551	0	fatty_acid	71,81	GPR120	59,65	fatty acid	GPR120	CHEBI:35366	338557	Chemical	Gene	receptor/sensor|amod|START_ENTITY gene|appos|receptor/sensor gene|amod|END_ENTITY	Mining microarray datasets in nutrition : expression of the GPR120 -LRB- n-3 fatty_acid receptor/sensor -RRB- gene is down-regulated in human adipocytes by macrophage secretions .
25535828	0	fatty_acid	5,15	GPR120	25,31	fatty acid	GPR120	CHEBI:35366	107221(Tax:10090)	Chemical	Gene	START_ENTITY|ccomp|expressed expressed|nsubjpass|END_ENTITY	Free fatty_acid receptor GPR120 is highly expressed in enteroendocrine K-cells of the upper small intestine and has a critical role in GIP secretion after fat ingestion .
16081037	0	fatty_acid	17,27	GPR40	8,13	fatty acid	GPR40	CHEBI:35366	2864	Chemical	Gene	action|amod|START_ENTITY Role|nmod|action Role|nmod|END_ENTITY	Role of GPR40 in fatty_acid action on the beta cell line INS-1E .
16214394	0	fatty_acid	14,24	GPR40	0,5	fatty acid	GPR40	CHEBI:35366	266607(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY END_ENTITY|appos|receptor	GPR40 , a free fatty_acid receptor on pancreatic beta cells , regulates insulin secretion .
16525841	0	fatty_acid	44,54	GPR40	127,132	fatty acid	GPR40	CHEBI:35366	2864	Chemical	Gene	receptor|amod|START_ENTITY gene|nmod|receptor Expression|nmod|gene Expression|dep|evidence evidence|nmod|expression expression|nummod|END_ENTITY	Expression of the gene for a membrane-bound fatty_acid receptor in the pancreas_and_islet_cell_tumours in humans : evidence for GPR40 expression in pancreatic beta cells and implications for insulin secretion .
17395749	0	fatty_acid	42,52	GPR40	0,5	fatty acid	GPR40	CHEBI:35366	233081(Tax:10090)	Chemical	Gene	stimulation|amod|START_ENTITY sufficient|nmod|stimulation sufficient|nsubj|END_ENTITY	GPR40 is necessary but not sufficient for fatty_acid stimulation of insulin secretion in vivo .
17525159	0	fatty_acid	41,51	GPR40	32,37	fatty acid	GPR40	CHEBI:35366	2864	Chemical	Gene	receptor|amod|START_ENTITY END_ENTITY|appos|receptor	Regulation of the gene encoding GPR40 , a fatty_acid receptor expressed selectively in pancreatic beta cells .
17583366	0	fatty_acid	19,29	GPR40	39,44	fatty acid	GPR40	CHEBI:35366	2864	Chemical	Gene	receptor|amod|START_ENTITY Expression|nmod|receptor END_ENTITY|nsubj|Expression	Expression of free fatty_acid receptor GPR40 in the central nervous system of adult monkeys .
17980148	0	fatty_acid	84,94	GPR40	65,70	fatty acid	GPR40	CHEBI:35366	2864	Chemical	Gene	receptor|amod|START_ENTITY FFAR1|dep|receptor END_ENTITY|dep|FFAR1	Production and characterization of a monoclonal antibody against GPR40 -LRB- FFAR1 ; free fatty_acid receptor 1 -RRB- .
18927207	0	fatty_acid	58,68	GPR40	39,44	fatty acid	GPR40	CHEBI:35366	2864	Chemical	Gene	receptor|amod|START_ENTITY FFAR1|dep|receptor END_ENTITY|dep|FFAR1	Flow cytometry-based binding assay for GPR40 -LRB- FFAR1 ; free fatty_acid receptor 1 -RRB- .
18947221	0	fatty_acid	56,66	GPR40	86,91	fatty acid	GPR40	CHEBI:35366	2864	Chemical	Gene	START_ENTITY|dobj|receptor receptor|dep|FFA FFA|dep|END_ENTITY	Discovery of potent and selective agonists for the free fatty_acid receptor 1 -LRB- FFA -LRB- 1 -RRB- / GPR40 -RRB- , a potential target for the treatment of type_II_diabetes .
23335512	0	fatty_acid	9,19	GPR40	60,65	fatty acid	GPR40	CHEBI:35366	233081(Tax:10090)	Chemical	Gene	G_protein-coupled_receptor_40|amod|START_ENTITY G_protein-coupled_receptor_40|appos|END_ENTITY	The free fatty_acid receptor G_protein-coupled_receptor_40 -LRB- GPR40 -RRB- protects from bone_loss through inhibition of osteoclast differentiation .
24584021	0	fatty_acid	67,77	GPR40	118,123	fatty acid	GPR40	CHEBI:35366	2864	Chemical	Gene	G_protein-coupled_receptor_40|amod|START_ENTITY G_protein-coupled_receptor_40|appos|END_ENTITY	-LSB- Antinociceptive effect of docosahexaenoic_acid -LRB- DHA -RRB- through long fatty_acid receptor G_protein-coupled_receptor_40 -LRB- GPR40 -RRB- -RSB- .
25281202	0	fatty_acid	40,50	GPR40	15,20	fatty acid	GPR40	CHEBI:35366	233081(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY END_ENTITY|appos|receptor	Involvement of GPR40 , a long-chain free fatty_acid receptor , in the production of central post-stroke_pain after global cerebral_ischemia .
26096679	0	fatty_acid	90,100	GPR40	113,118	fatty acid	GPR40	CHEBI:35366	2864	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Phenoxymethyl_1 ,3 - oxazoles and 1,2,4-oxadiazoles as potent and selective agonists of free fatty_acid receptor 1 -LRB- GPR40 -RRB- .
26331585	0	fatty_acid	43,53	GPR40	63,68	fatty acid	GPR40	CHEBI:35366	2864	Chemical	Gene	receptor|amod|START_ENTITY effects|nmod|receptor END_ENTITY|nsubj|effects	Negative effects of G-protein-coupled free fatty_acid receptor GPR40 on cell migration and invasion in fibrosarcoma HT1080 cells .
26791830	0	fatty_acid	102,112	GPR40	96,101	fatty acid	GPR40	CHEBI:35366	266607(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|nummod|END_ENTITY	Mercaptoacetate blocks fatty_acid-induced GLP-1 secretion in male rats by directly antagonizing GPR40 fatty_acid receptors .
16453106	0	fatty_acid	12,22	GPR43	33,38	fatty acid	GPR43	CHEBI:35366	292794(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Short-chain fatty_acid receptor , GPR43 , is expressed by enteroendocrine cells and mucosal mast cells in rat intestine .
17899402	0	fatty_acid	30,40	GPR43	51,56	fatty acid	GPR43	CHEBI:35366	2867	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Expression of the short-chain fatty_acid receptor , GPR43 , in the human colon .
22245676	0	fatty_acid	83,93	GPR84	118,123	fatty acid	GPR84	CHEBI:35366	80910(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY GPR84|appos|receptor expression|nmod|GPR84 enhance|dobj|expression enhance|parataxis|enhances enhances|dobj|expression expression|nummod|END_ENTITY	Inflammatory changes in adipose tissue enhance expression of GPR84 , a medium-chain fatty_acid receptor : TNFa enhances GPR84 expression in adipocytes .
22245676	0	fatty_acid	83,93	GPR84	61,66	fatty acid	GPR84	CHEBI:35366	80910(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY END_ENTITY|appos|receptor	Inflammatory changes in adipose tissue enhance expression of GPR84 , a medium-chain fatty_acid receptor : TNFa enhances GPR84 expression in adipocytes .
17556859	0	fatty_acid	38,48	Ghrelin	0,7	fatty acid	Ghrelin	CHEBI:35366	59301(Tax:10116)	Chemical	Gene	oxidation|amod|START_ENTITY reduces|dobj|oxidation reduces|nsubj|END_ENTITY	Ghrelin reduces hepatic mitochondrial fatty_acid beta oxidation .
19409434	0	fatty_acid	18,28	Ghrelin	0,7	fatty acid	Ghrelin	CHEBI:35366	408185(Tax:9031)	Chemical	Gene	START_ENTITY|nsubj|modulates modulates|compound|END_ENTITY	Ghrelin modulates fatty_acid synthase and related transcription factor mRNA levels in a tissue-specific manner in neonatal broiler chicks .
20335227	0	fatty_acid	67,77	Ghrelin	0,7	fatty acid	Ghrelin	CHEBI:35366	59301(Tax:10116)	Chemical	Gene	actions|amod|START_ENTITY depend|nmod|actions depend|nsubj|effects effects|compound|END_ENTITY	Ghrelin effects on neuropeptides in the rat hypothalamus depend on fatty_acid metabolism actions on BSX but not on gender .
6080087	0	fatty_acid	30,40	Growth_hormone	0,14	fatty acid	Growth hormone	CHEBI:35366	2688	Chemical	Gene	utilization|amod|START_ENTITY stimulation|nmod|utilization stimulation|amod|END_ENTITY	Growth_hormone stimulation of fatty_acid utilization by adipose tissue .
12900378	0	fatty_acid	66,76	H-FABP	19,25	fatty acid	H-FABP	CHEBI:35366	2170	Chemical	Gene	metabolism|amod|START_ENTITY inhibits|dobj|metabolism inhibits|nsubj|mutation mutation|nmod|END_ENTITY	A null mutation in H-FABP only partially inhibits skeletal muscle fatty_acid metabolism .
15068254	0	fatty_acid	11,21	H-FABP	39,45	fatty acid	H-FABP	CHEBI:35366	2170	Chemical	Gene	START_ENTITY|ccomp|decreased decreased|nsubjpass|protein protein|appos|END_ENTITY	Heart type fatty_acid binding protein -LRB- H-FABP -RRB- is decreased in brains of patients with Down syndrome and Alzheimer 's _ disease .
16574350	0	fatty_acid	22,32	H-FABP	108,114	fatty acid	H-FABP	CHEBI:35366	2170	Chemical	Gene	protein-1|amod|START_ENTITY pattern|nmod|protein-1 pattern|appos|genes genes|appos|END_ENTITY	Expression pattern of fatty_acid transport protein-1 -LRB- FATP-1 -RRB- , FATP-4 and heart-fatty_acid binding protein -LRB- H-FABP -RRB- genes in human term placenta .
20674495	0	fatty_acid	6,16	H-FABP	34,40	fatty acid	H-FABP	CHEBI:35366	2170	Chemical	Gene	START_ENTITY|dobj|protein protein|appos|END_ENTITY	Heart fatty_acid binding protein -LRB- H-FABP -RRB- as a diagnostic biomarker in patients with acute_coronary_syndrome .
23099200	0	fatty_acid	67,77	H-FABP	95,101	fatty acid	H-FABP	CHEBI:35366	2170	Chemical	Gene	START_ENTITY|dobj|protein protein|appos|END_ENTITY	Critical review and meta-analysis on the combination of heart-type fatty_acid binding protein -LRB- H-FABP -RRB- and troponin for early diagnosis of acute_myocardial_infarction .
25751665	0	fatty_acid	11,21	H-FABP	39,45	fatty acid	H-FABP	CHEBI:35366	2170	Chemical	Gene	binding|amod|START_ENTITY protein|amod|binding protein|appos|END_ENTITY	Heart-type fatty_acid binding protein -LRB- H-FABP -RRB- in patients in an emergency department setting , suspected of acute_coronary_syndrome : Optimal cut-off point , diagnostic value and future opportunities in primary care .
26564283	0	fatty_acid	19,29	H-FABP	47,53	fatty acid	H-FABP	CHEBI:35366	2170	Chemical	Gene	START_ENTITY|dobj|protein protein|appos|END_ENTITY	Bedside heart type fatty_acid binding protein -LRB- H-FABP -RRB- : Is an early predictive marker of cardiac_syncope .
10356659	0	fatty_acid	107,117	HMG-CoA_reductase	17,34	fatty acid	HMG-CoA reductase	CHEBI:35366	3156	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|inhibitors inhibitors|amod|END_ENTITY	Joint effects of HMG-CoA_reductase inhibitors and eicosapentaenoic_acids on serum lipid profile and plasma fatty_acid concentrations in patients with hyperlipidemia .
12079887	0	fatty_acid	63,73	I-FABP	91,97	fatty acid	I-FABP	CHEBI:35366	2169	Chemical	Gene	START_ENTITY|dobj|protein protein|appos|END_ENTITY	Detection of a promoter polymorphism in the gene of intestinal fatty_acid binding protein -LRB- I-FABP -RRB- .
14755801	0	fatty_acid	21,31	I-FABP	49,55	fatty acid	I-FABP	CHEBI:35366	30708(Tax:7955)	Chemical	Gene	START_ENTITY|dobj|protein protein|appos|END_ENTITY	Zebrafish intestinal fatty_acid binding protein -LRB- I-FABP -RRB- gene promoter drives gut-specific expression in stable transgenic fish .
15120958	0	fatty_acid	18,28	I-FABP	46,52	fatty acid	I-FABP	CHEBI:35366	595106(Tax:9823)	Chemical	Gene	START_ENTITY|dobj|concentrations concentrations|appos|END_ENTITY	Plasma intestinal fatty_acid binding protein -LRB- I-FABP -RRB- concentrations increase following intestinal_ischemia in pigs .
15254907	0	fatty_acid	54,64	I-FABP	82,88	fatty acid	I-FABP	CHEBI:35366	30708(Tax:7955)	Chemical	Gene	binding|amod|START_ENTITY expression|amod|binding expression|appos|END_ENTITY	Functional conserved elements mediate intestinal-type fatty_acid binding protein -LRB- I-FABP -RRB- expression in the gut epithelia of zebrafish larvae .
12809510	0	fatty_acid	56,66	IFABP	84,89	fatty acid	IFABP	CHEBI:35366	2169	Chemical	Gene	START_ENTITY|dobj|protein protein|appos|END_ENTITY	Temperature-induced conformational switch in intestinal fatty_acid binding protein -LRB- IFABP -RRB- revealing an alternative mode for ligand binding .
25311169	0	fatty_acid	20,30	IFABP	103,108	fatty acid	IFABP	CHEBI:35366	2169	Chemical	Gene	Characterization|nmod|START_ENTITY binding|nsubj|Characterization binding|dobj|form form|nmod|END_ENTITY	Characterization of fatty_acid binding and transfer from 98 , a functional all-b abridged form of IFABP .
17299765	0	fatty_acid	25,35	IGF-1	0,5	fatty acid	IGF-1	CHEBI:35366	3479	Chemical	Gene	START_ENTITY|nsubj|stimulates stimulates|compound|END_ENTITY	IGF-1 stimulates de novo fatty_acid biosynthesis by Schwann cells during myelination .
15383370	0	fatty_acid	31,41	IL-6	6,10	fatty acid	IL-6	CHEBI:35366	3569	Chemical	Gene	START_ENTITY|nsubj|increases increases|compound|END_ENTITY	Acute IL-6 treatment increases fatty_acid turnover in elderly humans in vivo and in tissue culture in vitro .
19258660	0	fatty_acid	26,36	IL-6	0,4	fatty acid	IL-6	CHEBI:35366	16193(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|increases increases|compound|END_ENTITY	IL-6 deficiency increases fatty_acid transporters and intramuscular lipid content in red but not white skeletal muscle .
23534555	0	fatty_acid	90,100	IL-6	0,4	fatty acid	IL-6	CHEBI:35366	16193(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|cooperates cooperates|compound|END_ENTITY	IL-6 cooperates with peroxisome proliferator-activated receptor-a-ligands to induce liver fatty_acid binding protein -LRB- LFABP -RRB- up-regulation .
10690936	0	fatty_acid	34,44	Insulin	0,7	fatty acid	Insulin	CHEBI:35366	3630	Chemical	Gene	concentrations|amod|START_ENTITY regulation|nmod|concentrations regulation|compound|END_ENTITY	Insulin regulation of plasma free fatty_acid concentrations is abnormal in healthy subjects with muscle insulin resistance .
12716789	0	fatty_acid	44,54	Insulin	0,7	fatty acid	Insulin	CHEBI:35366	3630	Chemical	Gene	START_ENTITY|nsubj|resistance resistance|compound|END_ENTITY	Insulin resistance , inflammation , and serum fatty_acid composition .
12870166	0	fatty_acid	60,70	Insulin	0,7	fatty acid	Insulin	CHEBI:35366	3630	Chemical	Gene	infusion|compound|START_ENTITY secretion|nmod|infusion secretion|nsubj|END_ENTITY	Insulin secretion after short - and long-term low-grade free fatty_acid infusion in men with increased risk of developing type 2 diabetes .
15736120	0	fatty_acid	48,58	Insulin	0,7	fatty acid	Insulin	CHEBI:35366	3630	Chemical	Gene	START_ENTITY|nsubj|indices indices|amod|END_ENTITY	Insulin sensitivity indices of glucose and free fatty_acid metabolism in obese children and adolescents in relation to serum lipids .
16528409	0	fatty_acid	104,114	Insulin	0,7	fatty acid	Insulin	CHEBI:35366	3630	Chemical	Gene	oxidation|amod|START_ENTITY increasing|dobj|oxidation reduces|advcl|increasing reduces|nsubj|resistance resistance|compound|END_ENTITY	Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty_acid oxidation .
17161228	0	fatty_acid	39,49	Insulin	0,7	fatty acid	Insulin	CHEBI:35366	3630	Chemical	Gene	analysis|nmod|START_ENTITY analysis|compound|END_ENTITY	Insulin dose response analysis of free fatty_acid kinetics .
18441389	0	fatty_acid	54,64	Insulin	0,7	fatty acid	Insulin	CHEBI:35366	3630	Chemical	Gene	CD36|amod|START_ENTITY expression|nmod|CD36 upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Insulin acutely upregulates protein expression of the fatty_acid transporter CD36 in human skeletal muscle in vivo .
21413848	0	fatty_acid	16,26	Insulin	0,7	fatty acid	Insulin	CHEBI:35366	3630	Chemical	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Insulin induces fatty_acid desaturase expression in human monocytes .
22560054	0	fatty_acid	44,54	Insulin	0,7	fatty acid	Insulin	CHEBI:35366	3630	Chemical	Gene	proteins|amod|START_ENTITY movement|nmod|proteins movement|compound|END_ENTITY	Insulin and contraction-induced movement of fatty_acid transport proteins to skeletal muscle transverse-tubules is distinctly different than to the sarcolemma .
22723441	0	fatty_acid	43,53	Insulin	0,7	fatty acid	Insulin	CHEBI:35366	3630	Chemical	Gene	uptake|amod|START_ENTITY nonesterified|dobj|uptake nonesterified|nsubj|activation activation|compound|END_ENTITY	Insulin activation of plasma nonesterified fatty_acid uptake in metabolic_syndrome .
2459120	0	fatty_acid	51,61	Insulin	0,7	fatty acid	Insulin	CHEBI:35366	3630	Chemical	Gene	transport|amod|START_ENTITY antagonism|nmod|transport antagonism|compound|END_ENTITY	Insulin antagonism of catecholamine stimulation of fatty_acid transport in the adipocyte .
2643754	0	fatty_acid	71,81	Insulin	0,7	fatty acid	Insulin	CHEBI:35366	3630	Chemical	Gene	pattern|amod|START_ENTITY phospholipid|dobj|pattern phospholipid|nsubj|secretion secretion|amod|END_ENTITY	Insulin secretion and insulin action related to the serum phospholipid fatty_acid pattern in healthy men .
3308603	0	fatty_acid	35,45	Insulin	0,7	fatty acid	Insulin	CHEBI:35366	3630	Chemical	Gene	START_ENTITY|nsubj|suppression suppression|compound|END_ENTITY	Insulin suppression of plasma-free fatty_acid concentration in normal individuals and patients with type 2 -LRB- non-insulin-dependent -RRB- diabetes .
559098	0	fatty_acid	23,33	Insulin	0,7	fatty acid	Insulin	CHEBI:35366	3630	Chemical	Gene	synthesis|amod|START_ENTITY stimulation|nmod|synthesis stimulation|compound|END_ENTITY	Insulin stimulation of fatty_acid synthesis in human breast_cancer cells .
7851683	0	fatty_acid	38,48	Insulin	0,7	fatty acid	Insulin	CHEBI:35366	3630	Chemical	Gene	composition|amod|START_ENTITY related|nmod|composition related|nsubjpass|sensitivity sensitivity|compound|END_ENTITY	Insulin sensitivity is related to the fatty_acid composition of serum lipids and skeletal muscle phospholipids in 70-year-old men .
908274	0	fatty_acid	23,33	Insulin	0,7	fatty acid	Insulin	CHEBI:35366	3630	Chemical	Gene	synthesis|amod|START_ENTITY stimulation|nmod|synthesis stimulation|compound|END_ENTITY	Insulin stimulation of fatty_acid synthesis in human breast_cancer in long term tissue culture .
12633865	0	fatty_acid	30,40	L-FABP	58,64	fatty acid	L-FABP	CHEBI:35366	171481(Tax:7955)	Chemical	Gene	START_ENTITY|dobj|protein protein|appos|END_ENTITY	In vivo studies of liver-type fatty_acid binding protein -LRB- L-FABP -RRB- gene expression in liver of transgenic zebrafish -LRB- Danio_rerio -RRB- .
12815620	0	fatty_acid	46,56	L-FABP	74,80	fatty acid	L-FABP	CHEBI:35366	171481(Tax:7955)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	435-bp liver regulatory sequence in the liver fatty_acid binding protein -LRB- L-FABP -RRB- gene is sufficient to modulate liver regional expression in transgenic zebrafish .
18854419	1	fatty_acid	150,160	L-FABP	178,184	fatty acid	L-FABP	CHEBI:35366	2168	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	BACKGROUND : Renoprotection of liver-type fatty_acid binding protein -LRB- L-FABP -RRB- was demonstrated in a streptozotocin -LRB- STZ -RRB- - induced diabetic_mouse model .
19285478	0	fatty_acid	11,21	L-FABP	39,45	fatty acid	L-FABP	CHEBI:35366	14080(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|protein protein|appos|END_ENTITY	Liver type fatty_acid binding protein -LRB- L-FABP -RRB- gene ablation reduces nuclear ligand distribution and peroxisome_proliferator-activated_receptor-alpha activity in cultured primary hepatocytes .
20721681	0	fatty_acid	22,32	L-FABP	0,6	fatty acid	L-FABP	CHEBI:35366	2168	Chemical	Gene	uptake|amod|START_ENTITY decreased|dobj|uptake decreased|nsubj|T94A T94A|compound|END_ENTITY	L-FABP T94A decreased fatty_acid uptake and altered hepatic triglyceride and cholesterol accumulation in Chang liver cells stably transfected with L-FABP .
21356355	0	fatty_acid	17,27	L-FABP	45,51	fatty acid	L-FABP	CHEBI:35366	14080(Tax:10090)	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Renal liver-type fatty_acid binding protein -LRB- L-FABP -RRB- attenuates acute_kidney_injury in aristolochic_acid nephrotoxicity .
24205707	0	fatty_acid	16,26	L-FABP	44,50	fatty acid	L-FABP	CHEBI:35366	2168	Chemical	Gene	START_ENTITY|dobj|protein protein|appos|END_ENTITY	-LSB- Urinary L-type fatty_acid binding protein -LRB- L-FABP -RRB- as a new urinary biomarker promulgated by the Ministry of Health , Labour and Welfare in Japan -RSB- .
24610891	0	fatty_acid	43,53	L-FABP	76,82	fatty acid	L-FABP	CHEBI:35366	14080(Tax:10090)	Chemical	Gene	START_ENTITY|xcomp|channeling channeling|nmod|mechanism mechanism|amod|END_ENTITY	Hepatic ATGL mediates PPAR-a signaling and fatty_acid channeling through an L-FABP independent mechanism .
24800492	0	fatty_acid	8,18	L-FABP	36,42	fatty acid	L-FABP	CHEBI:35366	2168	Chemical	Gene	START_ENTITY|dobj|protein protein|appos|END_ENTITY	-LSB- L-type fatty_acid binding protein -LRB- L-FABP -RRB- and kidney_disease -RSB- .
23921281	0	fatty_acid	62,72	L-Fabp	34,40	fatty acid	L-Fabp	CHEBI:35366	14080(Tax:10090)	Chemical	Gene	composition|compound|START_ENTITY modifies|dobj|composition modifies|nsubj|protein protein|appos|END_ENTITY	Liver fatty_acid-binding protein -LRB- L-Fabp -RRB- modifies intestinal fatty_acid composition and adenoma formation in ApcMin / + mice .
9714723	0	fatty_acid	148,158	LCAD	125,129	fatty acid	LCAD	CHEBI:35366	33	Chemical	Gene	oxidation|amod|START_ENTITY END_ENTITY|nmod|oxidation	2,6-Dimethylheptanoyl-CoA is a specific substrate for long-chain_acyl-CoA_dehydrogenase -LRB- LCAD -RRB- : evidence for a major role of LCAD in branched-chain fatty_acid oxidation .
20541621	0	fatty_acid	47,57	LFABP	75,80	fatty acid	LFABP	CHEBI:35366	2168	Chemical	Gene	START_ENTITY|dobj|protein protein|appos|END_ENTITY	Natural ligand binding and transfer from liver fatty_acid binding protein -LRB- LFABP -RRB- to membranes .
23534555	0	fatty_acid	90,100	LFABP	118,123	fatty acid	LFABP	CHEBI:35366	14080(Tax:10090)	Chemical	Gene	START_ENTITY|xcomp|up-regulation up-regulation|nsubj|protein protein|appos|END_ENTITY	IL-6 cooperates with peroxisome proliferator-activated receptor-a-ligands to induce liver fatty_acid binding protein -LRB- LFABP -RRB- up-regulation .
18782084	0	fatty_acid	78,88	LXRalpha	141,149	fatty acid	LXRalpha	CHEBI:35366	10062	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Hepatitis_B_virus X protein induces lipogenic transcription factor SREBP1 and fatty_acid synthase through the activation of nuclear receptor LXRalpha .
10329986	0	fatty_acid	36,46	Leptin	0,6	fatty acid	Leptin	CHEBI:35366	16846(Tax:10090)	Chemical	Gene	partitioning|amod|START_ENTITY opposes|nmod|partitioning opposes|nsubj|END_ENTITY	Leptin opposes insulin 's effects on fatty_acid partitioning in muscles isolated from obese_ob / ob_mice .
11342529	0	fatty_acid	143,153	Leptin	0,6	fatty acid	Leptin	CHEBI:35366	3952	Chemical	Gene	oxidation|amod|START_ENTITY increasing|dobj|oxidation induces|advcl|increasing induces|nsubj|END_ENTITY	Leptin induces mitochondrial superoxide production and monocyte_chemoattractant_protein-1 expression in aortic endothelial cells by increasing fatty_acid oxidation via protein kinase A. Leptin , a circulating hormone secreted mainly from adipose tissues , is involved in the control of body weight .
12058043	0	fatty_acid	25,35	Leptin	0,6	fatty acid	Leptin	CHEBI:35366	25608(Tax:10116)	Chemical	Gene	independent|amod|START_ENTITY activates|dobj|independent activates|nsubj|END_ENTITY	Leptin activates cardiac fatty_acid oxidation independent of changes in the AMP-activated protein kinase-acetyl-CoA carboxylase-malonyl-CoA axis .
12949354	0	fatty_acid	113,123	Leptin	0,6	fatty acid	Leptin	CHEBI:35366	16846(Tax:10090)	Chemical	Gene	uptake|amod|START_ENTITY regulation|nmod|uptake modulate|nmod|regulation modulate|nsubj|END_ENTITY	Leptin and insulin modulate nutrient partitioning and weight_loss in ob/ob mice through regulation of long-chain fatty_acid uptake by adipocytes .
14669153	0	fatty_acid	84,94	Lipoprotein_lipase	0,18	fatty acid	Lipoprotein lipase	CHEBI:35366	24539(Tax:10116)	Chemical	Gene	enzymes|amod|START_ENTITY expression|nmod|enzymes accelerates|dobj|expression accelerates|nsubj|NO-1886 NO-1886|amod|END_ENTITY	Lipoprotein_lipase activator NO-1886 -LRB- ibrolipim -RRB- accelerates the mRNA expression of fatty_acid oxidation-related enzymes in rat liver .
19903962	0	fatty_acid	33,43	Liver_X_receptor_alpha	0,22	fatty acid	Liver X receptor alpha	CHEBI:35366	395221(Tax:9031)	Chemical	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Liver_X_receptor_alpha regulates fatty_acid synthase expression in chicken .
17374366	0	fatty_acid	16,26	MUC2	49,53	fatty acid	MUC2	CHEBI:35366	4583	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|compound|END_ENTITY	The short chain fatty_acid , butyrate , stimulates MUC2 mucin production in the human colon_cancer cell line , LS174T .
16100246	0	fatty_acid	48,58	Malonyl-CoA_decarboxylase	0,25	fatty acid	Malonyl-CoA decarboxylase	CHEBI:35366	497060(Tax:9823)	Chemical	Gene	START_ENTITY|nsubj|suppresses suppresses|amod|END_ENTITY	Malonyl-CoA_decarboxylase inhibition suppresses fatty_acid oxidation and reduces lactate production during demand-induced ischemia .
12703631	0	fatty_acid	89,99	Milk	0,4	fatty acid	Milk	CHEBI:35366	100532204	Chemical	Gene	profiles|amod|START_ENTITY differing|nmod|profiles diets|acl|differing supplementation|nmod|diets conjugated|nmod|supplementation conjugated|nsubj|END_ENTITY	Milk conjugated linoleic_acid response to fish oil supplementation of diets differing in fatty_acid profiles .
14594244	0	fatty_acid	5,15	Milk	0,4	fatty acid	Milk	CHEBI:35366	100532204	Chemical	Gene	composition|amod|START_ENTITY composition|compound|END_ENTITY	Milk fatty_acid composition of cows fed a total mixed ration or pasture plus concentrates replacing corn with fat .
22720915	0	fatty_acid	5,15	Milk	0,4	fatty acid	Milk	CHEBI:35366	100532204	Chemical	Gene	composition|compound|START_ENTITY composition|compound|END_ENTITY	Milk fatty_acid composition and production performance of Danish Holstein and Danish Jersey cows fed different amounts of linseed and rapeseed .
24422608	0	fatty_acid	5,15	Milk	0,4	fatty acid	Milk	CHEBI:35366	100532204	Chemical	Gene	profiles|compound|START_ENTITY profiles|compound|END_ENTITY	Milk fatty_acid profiles in Holstein dairy cows fed diets based on corn stover or mixed forage .
21757690	0	fatty_acid	40,50	NR4A2	24,29	fatty acid	NR4A2	CHEBI:35366	4929	Chemical	Gene	START_ENTITY|nsubj|modulates modulates|compound|END_ENTITY	Nuclear orphan receptor NR4A2 modulates fatty_acid oxidation pathways in colorectal_cancer .
1978720	0	fatty_acid	62,72	OLE1	4,8	fatty acid	OLE1	CHEBI:35366	852825(Tax:4932)	Chemical	Gene	desaturase|amod|START_ENTITY encodes|dobj|desaturase encodes|nsubj|gene gene|compound|END_ENTITY	The OLE1 gene of Saccharomyces_cerevisiae encodes the delta 9 fatty_acid desaturase and can be functionally replaced by the rat stearoyl-CoA desaturase gene .
2674136	0	fatty_acid	57,67	OLE1	34,38	fatty acid	OLE1	CHEBI:35366	852825(Tax:4932)	Chemical	Gene	desaturation|amod|START_ENTITY affecting|dobj|desaturation gene|acl|affecting Isolation|appos|gene Isolation|nmod|END_ENTITY	Isolation and characterization of OLE1 , a gene affecting fatty_acid desaturation from Saccharomyces_cerevisiae .
9280286	0	fatty_acid	80,90	OLE1	108,112	fatty acid	OLE1	CHEBI:35366	852825(Tax:4932)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Isolation and characterization of mutations affecting expression of the delta9 - fatty_acid desaturase gene , OLE1 , in Saccharomyces_cerevisiae .
20850500	0	fatty_acid	18,28	PA3859	78,84	fatty acid	PA3859	CHEBI:35366	879801(Tax:208964)	Chemical	Gene	specificity|amod|START_ENTITY specificity|nmod|END_ENTITY	Insights into the fatty_acid chain length specificity of the carboxylesterase PA3859 from Pseudomonas_aeruginosa : A combined structural , biochemical and computational study .
26347999	0	fatty_acid	30,40	PNPLA3	0,6	fatty acid	PNPLA3	CHEBI:35366	116939(Tax:10090)	Chemical	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	PNPLA3 is involved in hepatic fatty_acid and triglyceride metabolism through XBP1 and modulation of endoplasmic reticulum stress in mice .
26347999	0	fatty_acid	30,40	PNPLA3	0,6	fatty acid	PNPLA3	CHEBI:35366	116939(Tax:10090)	Chemical	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	PNPLA3 is involved in hepatic fatty_acid and triglyceride metabolism through XBP1 and modulation of endoplasmic reticulum stress in mice .
19439812	0	fatty_acid	67,77	PPAR_alpha	32,42	fatty acid	PPAR alpha	CHEBI:35366	25747(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY effects|nmod|expression effects|nmod|END_ENTITY	Differential effects of in vivo PPAR_alpha and gamma activation on fatty_acid transport proteins expression and lipid content in rat liver .
10869548	0	fatty_acid	16,26	PPARalpha	48,57	fatty acid	PPARalpha	CHEBI:35366	19013(Tax:10090)	Chemical	Gene	oxidation|amod|START_ENTITY oxidation|nmod|END_ENTITY	Reduced hepatic fatty_acid oxidation in fasting PPARalpha null mice is due to impaired mitochondrial hydroxymethylglutaryl-CoA synthase gene expression .
17694178	0	fatty_acid	6,16	PPARalpha	36,45	fatty acid	PPARalpha	CHEBI:35366	19013(Tax:10090)	Chemical	Gene	START_ENTITY|ccomp|activates activates|dobj|END_ENTITY	Brain fatty_acid synthase activates PPARalpha to maintain energy homeostasis .
19577662	0	fatty_acid	34,44	PPARalpha	58,67	fatty acid	PPARalpha	CHEBI:35366	19013(Tax:10090)	Chemical	Gene	oxidation|amod|START_ENTITY oxidation|nmod|END_ENTITY	A pan-PPAR ligand induces hepatic fatty_acid oxidation in PPARalpha - / - mice possibly through PGC-1 mediated PPARdelta coactivation .
15833283	0	fatty_acid	161,171	Peroxisome_proliferator-activated_receptor_alpha	0,48	fatty acid	Peroxisome proliferator-activated receptor alpha	CHEBI:35366	19013(Tax:10090)	Chemical	Gene	binding|amod|START_ENTITY gene|amod|binding required|dobj|gene required|nsubjpass|END_ENTITY	Peroxisome_proliferator-activated_receptor_alpha and its response element are required but not sufficient for transcriptional activation of the mouse heart-type fatty_acid binding protein gene .
16106047	0	fatty_acid	107,117	Peroxisome_proliferator-activated_receptor_alpha	0,48	fatty acid	Peroxisome proliferator-activated receptor alpha	CHEBI:35366	19013(Tax:10090)	Chemical	Gene	synthesis|amod|START_ENTITY regulation|nmod|synthesis required|nmod|regulation required|nsubjpass|END_ENTITY	Peroxisome_proliferator-activated_receptor_alpha is required for feedback regulation of highly unsaturated fatty_acid synthesis .
16540100	0	fatty_acid	107,117	Peroxisome_proliferator-activated_receptor_alpha	0,48	fatty acid	Peroxisome proliferator-activated receptor alpha	CHEBI:35366	25747(Tax:10116)	Chemical	Gene	composition|amod|START_ENTITY influence|nmod|composition has|dobj|influence has|nsubj|agonist agonist|amod|END_ENTITY	Peroxisome_proliferator-activated_receptor_alpha agonist , clofibrate , has profound influence on myocardial fatty_acid composition .
19617640	0	fatty_acid	92,102	Peroxisome_proliferator-activated_receptor_alpha	0,48	fatty acid	Peroxisome proliferator-activated receptor alpha	CHEBI:35366	25747(Tax:10116)	Chemical	Gene	composition|amod|START_ENTITY induces|nmod|composition induces|nsubj|activation activation|amod|END_ENTITY	Peroxisome_proliferator-activated_receptor_alpha activation induces unfavourable changes in fatty_acid composition of myocardial_phospholipids .
18635652	0	fatty_acid	44,54	Regulator_of_G_protein_signaling-4	0,34	fatty acid	Regulator of G protein signaling-4	CHEBI:35366	19736(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY controls|dobj|homeostasis controls|nsubj|END_ENTITY	Regulator_of_G_protein_signaling-4 controls fatty_acid and glucose homeostasis .
9245689	0	fatty_acid	177,187	SCPx	154,158	fatty acid	SCPx	CHEBI:35366	6342	Chemical	Gene	metabolism|amod|START_ENTITY END_ENTITY|nmod|metabolism	Sterol_carrier_protein_X -LRB- SCPx -RRB- is a peroxisomal branched-chain beta-ketothiolase specifically reacting with 3-oxo-pristanoyl-CoA : a new , unique role for SCPx in branched-chain fatty_acid metabolism in peroxisomes .
9245689	0	fatty_acid	177,187	SCPx	26,30	fatty acid	SCPx	CHEBI:35366	6342	Chemical	Gene	metabolism|amod|START_ENTITY SCPx|nmod|metabolism role|nmod|SCPx beta-ketothiolase|dep|role beta-ketothiolase|nsubj|Sterol_carrier_protein_X Sterol_carrier_protein_X|appos|END_ENTITY	Sterol_carrier_protein_X -LRB- SCPx -RRB- is a peroxisomal branched-chain beta-ketothiolase specifically reacting with 3-oxo-pristanoyl-CoA : a new , unique role for SCPx in branched-chain fatty_acid metabolism in peroxisomes .
21901160	0	fatty_acid	42,52	SIRT3	81,86	fatty acid	SIRT3	CHEBI:35366	293615(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|expression expression|compound|END_ENTITY	Maternal obesity during gestation impairs fatty_acid oxidation and mitochondrial SIRT3 expression in rat offspring at weaning .
20685656	0	fatty_acid	16,26	SIRT4	0,5	fatty acid	SIRT4	CHEBI:35366	75387(Tax:10090)	Chemical	Gene	oxidation|amod|START_ENTITY regulates|dobj|oxidation regulates|nsubj|END_ENTITY	SIRT4 regulates fatty_acid oxidation and mitochondrial gene expression in liver and muscle cells .
15983196	0	fatty_acid	18,28	STAT5A	41,47	fatty acid	STAT5A	CHEBI:35366	24918(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY synthase|nsubj|regulation synthase|nmod|END_ENTITY	The regulation of fatty_acid synthase by STAT5A .
16027120	0	fatty_acid	82,92	Slc25a10	40,48	fatty acid	Slc25a10	CHEBI:35366	27376(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification of dicarboxylate carrier Slc25a10 as malate transporter in de novo fatty_acid synthesis .
10618488	0	fatty_acid	30,40	Sp1	85,88	fatty acid	Sp1	CHEBI:35366	24790(Tax:10116)	Chemical	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Transcriptional regulation of fatty_acid synthase gene and ATP_citrate-lyase gene by Sp1 and Sp3 in rat hepatocytes -LRB- 1 -RRB- .
17699067	0	fatty_acid	58,68	Stearoyl-coenzyme_A_desaturase	0,30	fatty acid	Stearoyl-coenzyme A desaturase	CHEBI:35366	280924(Tax:9913)	Chemical	Gene	START_ENTITY|nsubj|polymorphism polymorphism|amod|END_ENTITY	Stearoyl-coenzyme_A_desaturase gene polymorphism and milk fatty_acid composition in Italian Holsteins .
23403193	0	fatty_acid	88,98	Sterol_regulatory_element_binding_transcription_factor_1	0,56	fatty acid	Sterol regulatory element binding transcription factor 1	CHEBI:35366	6720	Chemical	Gene	START_ENTITY|nsubj|polymorphism polymorphism|amod|END_ENTITY	Sterol_regulatory_element_binding_transcription_factor_1 -LRB- SREBF1 -RRB- polymorphism and milk fatty_acid composition .
19662161	0	fatty_acid	67,77	TAT-2	14,19	fatty acid	TAT-2	CHEBI:35366	177256(Tax:6239)	Chemical	Gene	regulates|ccomp|START_ENTITY regulates|nsubj|END_ENTITY	P-type ATPase TAT-2 negatively regulates monomethyl branched-chain fatty_acid mediated function in post-embryonic growth and development in C. _ elegans .
19666541	0	fatty_acid	36,46	TR4	0,3	fatty acid	TR4	CHEBI:35366	22026(Tax:10090)	Chemical	Gene	sensor|amod|START_ENTITY functions|nmod|sensor functions|nummod|END_ENTITY	TR4 nuclear receptor functions as a fatty_acid sensor to modulate CD36 expression and foam cell formation .
12940866	0	fatty_acid	10,20	UCP3	65,69	fatty acid	UCP3	CHEBI:35366	22229(Tax:10090)	Chemical	Gene	oxidation|amod|START_ENTITY oxidation|nmod|END_ENTITY	Increased fatty_acid oxidation in transgenic_mice overexpressing UCP3 in skeletal muscle .
15666804	0	fatty_acid	39,49	Y-1	64,67	fatty acid	Y-1	CHEBI:35366	6084	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Multiple contributions from long-chain fatty_acid metabolism in Y-1 and MA-10 cells .
17502136	0	fatty_acid	60,70	aFABP	88,93	fatty acid	aFABP	CHEBI:35366	2167	Chemical	Gene	START_ENTITY|dobj|protein protein|appos|END_ENTITY	Potent and selective biphenyl_azole inhibitors of adipocyte fatty_acid binding protein -LRB- aFABP -RRB- .
18375128	0	fatty_acid	28,38	aP2	56,59	fatty acid	aP2	CHEBI:35366	2167	Chemical	Gene	START_ENTITY|dobj|protein protein|appos|END_ENTITY	NMR evaluation of adipocyte fatty_acid binding protein -LRB- aP2 -RRB- with R - _ and_S-ibuprofen .
20509169	0	fatty_acid	45,55	aP2	73,76	fatty acid	aP2	CHEBI:35366	2167	Chemical	Gene	START_ENTITY|dobj|protein protein|appos|END_ENTITY	X-ray crystallographic analysis of adipocyte fatty_acid binding protein -LRB- aP2 -RRB- modified with 4-hydroxy-2-nonenal .
25535287	0	fatty_acid	13,23	aP2	40,43	fatty acid	aP2	CHEBI:35366	2167	Chemical	Gene	protein|amod|START_ENTITY Secretion|nmod|protein END_ENTITY|nsubj|Secretion	Secretion of fatty_acid binding protein aP2 from adipocytes through a non-classical pathway in response to adipocyte lipase activity .
8910278	0	fatty_acid	96,106	aP2	77,80	fatty acid	aP2	CHEBI:35366	11770(Tax:10090)	Chemical	Gene	START_ENTITY|advcl|Uncoupling Uncoupling|nmod|mutation mutation|nmod|END_ENTITY	Uncoupling of obesity from insulin resistance through a targeted mutation in aP2 , the adipocyte fatty_acid binding protein .
8499488	0	fatty_acid	50,60	acyl-CoA_binding_protein	24,48	fatty acid	acyl-CoA binding protein	CHEBI:35366	25045(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|induction induction|nmod|END_ENTITY	Coordinate induction of acyl-CoA_binding_protein , fatty_acid binding protein and peroxisomal beta-oxidation by peroxisome proliferators .
17481768	0	fatty_acid	34,44	adiponectin	8,19	fatty acid	adiponectin	CHEBI:35366	9370	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of adiponectin and adipocyte fatty_acid binding protein in the metabolic_syndrome .
19099980	0	fatty_acid	28,38	adiponectin	7,18	fatty acid	adiponectin	CHEBI:35366	9370	Chemical	Gene	START_ENTITY|nsubj|Serum Serum|amod|END_ENTITY	-LSB- Serum adiponectin and free fatty_acid profile in essential hypertensive patients with or without metabolic_syndrome -RSB- .
15652523	0	fatty_acid	21,31	albumin	8,15	fatty acid	albumin	CHEBI:35366	213	Chemical	Gene	carrier|amod|START_ENTITY END_ENTITY|nmod|carrier	Role of albumin as a fatty_acid carrier for biosynthesis of lens lipids .
19709838	0	fatty_acid	81,91	albumin	43,50	fatty acid	albumin	CHEBI:35366	213	Chemical	Gene	level|nmod|START_ENTITY induced|nmod|level Alterations|acl|induced Alterations|nmod|END_ENTITY	Alterations of furosemide binding to serum albumin induced by increased level of fatty_acid .
2437944	0	fatty_acid	24,34	albumin	110,117	fatty acid	albumin	CHEBI:35366	213	Chemical	Gene	modulation|amod|START_ENTITY modulation|nmod|kinetics kinetics|nmod|site site|nmod|END_ENTITY	Age-dependence and free fatty_acid modulation of binding kinetics at the benzodiazepine binding site of serum albumin in neonates and adults determined using fast reaction methods .
638196	0	fatty_acid	13,23	albumin	89,96	fatty acid	albumin	CHEBI:35366	213	Chemical	Gene	START_ENTITY|acl|focusing focusing|nmod|focusing focusing|nmod|END_ENTITY	Influence of fatty_acid and time of focusing on the isoelectric focusing of human plasma albumin .
9312942	0	fatty_acid	16,26	albumin	48,55	fatty acid	albumin	CHEBI:35366	213	Chemical	Gene	composition|amod|START_ENTITY composition|nmod|END_ENTITY	-LSB- Changes in the fatty_acid composition of serum albumin in patients with lung and breast_neoplasms -RSB- .
6183647	0	fatty_acid	4,14	alpha-fetoprotein	29,46	fatty acid	alpha-fetoprotein	CHEBI:35366	24177(Tax:10116)	Chemical	Gene	levels|amod|START_ENTITY levels|nmod|END_ENTITY	The fatty_acid levels of rat alpha-fetoprotein derived from fetuses , pregnancy and hepatoma sera .
6190512	0	fatty_acid	30,40	alpha-fetoprotein	7,24	fatty acid	alpha-fetoprotein	CHEBI:35366	24177(Tax:10116)	Chemical	Gene	carrier|amod|START_ENTITY END_ENTITY|nmod|carrier	On rat alpha-fetoprotein as a fatty_acid carrier .
7504462	0	fatty_acid	4,14	alpha-fetoprotein	37,54	fatty acid	alpha-fetoprotein	CHEBI:35366	174	Chemical	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	The fatty_acid binding site of human alpha-fetoprotein .
21357625	0	fatty_acid	58,68	carbohydrate_response_element-binding_protein	84,129	fatty acid	carbohydrate response element-binding protein	CHEBI:35366	58805(Tax:10090)	Chemical	Gene	oxidation|amod|START_ENTITY oxidation|nmod|END_ENTITY	Regulator of G protein signaling -LRB- RGS16 -RRB- inhibits hepatic fatty_acid oxidation in a carbohydrate_response_element-binding_protein -LRB- ChREBP -RRB- - dependent manner .
15846373	0	fatty_acid	42,52	carnitine_palmitoyltransferase-1	109,141	fatty acid	carnitine palmitoyltransferase-1	CHEBI:35366	1374	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	tBid induces alterations of mitochondrial fatty_acid oxidation flux by malonyl-CoA-independent inhibition of carnitine_palmitoyltransferase-1 .
24984811	0	fatty_acid	23,33	carnitine_palmitoyltransferase_1C	71,104	fatty acid	carnitine palmitoyltransferase 1C	CHEBI:35366	126129	Chemical	Gene	synthase|amod|START_ENTITY synthase|nmod|END_ENTITY	Elevated expression of fatty_acid synthase and nuclear localization of carnitine_palmitoyltransferase_1C are common among human gliomas .
3415664	0	fatty_acid	22,32	carnitine_palmitoyltransferase_I	46,78	fatty acid	carnitine palmitoyltransferase I	CHEBI:35366	25756(Tax:10116)	Chemical	Gene	oxidation|amod|START_ENTITY oxidation|nmod|END_ENTITY	Inhibition of hepatic fatty_acid oxidation at carnitine_palmitoyltransferase_I by the peroxisome proliferator 2-hydroxy-3-propyl-4 - -LSB- 6 - -LRB- tetrazol-5-yl -RRB- _ hexyloxy -RSB- acetophenone .
25783893	0	fatty_acid	101,111	chicken_ovalbumin_upstream_promoter_transcription_factor_II	12,71	fatty acid	chicken ovalbumin upstream promoter transcription factor II	CHEBI:35366	11819(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	The role of chicken_ovalbumin_upstream_promoter_transcription_factor_II in the regulation of hepatic fatty_acid oxidation and gluconeogenesis in newborn mice .
18662427	0	fatty_acid	187,197	cholesteryl_ester_transfer_protein	124,158	fatty acid	cholesteryl ester transfer protein	CHEBI:35366	1071	Chemical	Gene	protein|amod|START_ENTITY protein|compound|END_ENTITY	Human fasting plasma concentrations of vitamin_E and carotenoids , and their association with genetic variants in apo C-III , cholesteryl_ester_transfer_protein , hepatic_lipase , intestinal fatty_acid binding protein and microsomal triacylglycerol transfer protein .
958360	2	fatty_acid	113,123	citrate_synthase	76,92	fatty acid	citrate synthase	CHEBI:35366	170587(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Activity Activity|nmod|END_ENTITY	Activity of citrate_synthase , ATP_citrate_lyase , fatty_acid synthase , and glucose-6-phosphate_dehydrogenase in liver of growing rats on diets differing in fat content -RSB- .
20463020	0	fatty_acid	20,30	cyclooxygenase-2	52,68	fatty acid	cyclooxygenase-2	CHEBI:35366	19225(Tax:10090)	Chemical	Gene	substrate|amod|START_ENTITY basis|nmod|substrate basis|amod|END_ENTITY	Structural basis of fatty_acid substrate binding to cyclooxygenase-2 .
24779988	0	fatty_acid	59,69	cyclooxygenase-2	32,48	fatty acid	cyclooxygenase-2	CHEBI:35366	5743	Chemical	Gene	START_ENTITY|nsubj|analysis analysis|nmod|END_ENTITY	Immunohistochemical analysis of cyclooxygenase-2 and brain fatty_acid binding protein expression in grades_I-II_meningiomas : Correlation with tumor grade and clinical outcome after radiotherapy .
1711781	0	fatty_acid	22,32	decay-accelerating_factor	55,80	fatty acid	decay-accelerating factor	CHEBI:35366	1604	Chemical	Gene	START_ENTITY|dobj|gene gene|amod|END_ENTITY	Expression of a liver fatty_acid binding protein/human decay-accelerating_factor / HLA-B44 chimeric gene in transgenic_mice .
10601301	0	fatty_acid	25,35	delta-5_desaturase	60,78	fatty acid	delta-5 desaturase	CHEBI:35366	3992	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Cloning , expression , and fatty_acid regulation of the human delta-5_desaturase .
19875987	0	fatty_acid	16,26	delta-6_and_delta-5_desaturase	27,57	fatty acid	delta-6 and delta-5 desaturase	CHEBI:35366	9415	Chemical	Gene	START_ENTITY|dobj|activity activity|amod|END_ENTITY	Decreased liver fatty_acid delta-6_and_delta-5_desaturase activity in obese patients .
7833822	0	fatty_acid	51,61	delta-9-desaturase	25,43	fatty acid	delta-9-desaturase	CHEBI:35366	3995	Chemical	Gene	metabolism|amod|START_ENTITY END_ENTITY|nmod|metabolism	The role of delta-6 - and delta-9-desaturase in the fatty_acid metabolism of hepatomas with different growth rate .
9395511	0	fatty_acid	75,85	estrogen-related_receptor_alpha	11,42	fatty acid	estrogen-related receptor alpha	CHEBI:35366	26379(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	A role for estrogen-related_receptor_alpha in the control of mitochondrial fatty_acid beta-oxidation during brown adipocyte differentiation .
11680675	0	fatty_acid	14,24	ex-FABP	42,49	fatty acid	ex-FABP	CHEBI:35366	396393(Tax:9031)	Chemical	Gene	START_ENTITY|ccomp|protein protein|nsubj|protein protein|appos|END_ENTITY	Extracellular fatty_acid binding protein -LRB- ex-FABP -RRB- is a stress protein expressed during chondrocyte and myoblast differentiation .
21798188	0	fatty_acid	54,64	fabp2	82,87	fatty acid	fabp2	CHEBI:35366	30708(Tax:7955)	Chemical	Gene	START_ENTITY|ccomp|reveals reveals|nsubj|genes genes|appos|END_ENTITY	Genomic organization of Atlantic_salmon -LRB- Salmo_salar -RRB- fatty_acid binding protein -LRB- fabp2 -RRB- genes reveals independent loss of duplicate loci in teleosts .
22575613	0	fatty_acid	65,75	fabp7	135,140	fatty acid	fabp7	CHEBI:35366	100196877(Tax:8030)	Chemical	Gene	START_ENTITY|ccomp|reveals reveals|dobj|fates fates|nmod|genes genes|amod|END_ENTITY	Characterization of the Atlantic_salmon -LRB- Salmo_salar -RRB- brain-type fatty_acid binding protein -LRB- fabp7 -RRB- genes reveals the fates of teleost fabp7 genes following whole genome duplications .
22575613	0	fatty_acid	65,75	fabp7	93,98	fatty acid	fabp7	CHEBI:35366	100196877(Tax:8030)	Chemical	Gene	START_ENTITY|ccomp|reveals reveals|nsubj|genes genes|appos|END_ENTITY	Characterization of the Atlantic_salmon -LRB- Salmo_salar -RRB- brain-type fatty_acid binding protein -LRB- fabp7 -RRB- genes reveals the fates of teleost fabp7 genes following whole genome duplications .
11571758	0	fatty_acid	13,23	fas1	133,137	fatty acid	fas1	CHEBI:35366	853653(Tax:4932)	Chemical	Gene	gene|amod|START_ENTITY Cloning|nmod|gene cerevisiae|nsubj|Cloning cerevisiae|dobj|mutant mutant|amod|END_ENTITY	Cloning of a fatty_acid synthase component FAS1 gene from Saccharomyces_kluyveri and its functional complementation of S. _ cerevisiae fas1 mutant .
4590685	0	fatty_acid	76,86	fas1	112,116	fatty acid	fas1	CHEBI:35366	853653(Tax:4932)	Chemical	Gene	complex|amod|START_ENTITY complex|appos|END_ENTITY	Genetic analysis of hybrid strains trisomic for the chromosome containing a fatty_acid synthetase gene complex -LRB- fas1 -RRB- in yeast .
10868951	0	fatty_acid	13,23	fat	200,203	fatty acid	fat	CHEBI:35366	948	Chemical	Gene	translocase/CD36|amod|START_ENTITY Induction|nmod|translocase/CD36 Induction|amod|END_ENTITY	Induction of fatty_acid translocase/CD36 , peroxisome_proliferator-activated_receptor-gamma2 , _ leptin , _ uncoupling_proteins_2_and_3 , and tumor_necrosis_factor-alpha gene expression in human subcutaneous fat by lipid infusion .
19012600	0	fatty_acid	26,36	fat	89,92	fatty acid	fat	CHEBI:35366	948	Chemical	Gene	translocase|amod|START_ENTITY Identification|nmod|translocase Identification|dep|transcript transcript|nmod|END_ENTITY	Identification of porcine fatty_acid translocase : high-level transcript in intramuscular fat .
22010241	0	fatty_acid	23,33	fat	78,81	fatty acid	fat	CHEBI:35366	395168(Tax:9031)	Chemical	Gene	translocase|amod|START_ENTITY immunization|nmod|translocase decreased|nsubj|immunization decreased|dobj|deposition deposition|amod|END_ENTITY	Active immunization of fatty_acid translocase specifically decreased visceral fat deposition in male broilers .
26197708	0	fatty_acid	28,38	fat	140,143	fatty acid	fat	CHEBI:35366	29184(Tax:10116)	Chemical	Gene	transport|amod|START_ENTITY increase|nmod|transport delayed|nsubj|increase delayed|nmod|feeding feeding|amod|END_ENTITY	Extremely rapid increase in fatty_acid transport and intramyocellular lipid accumulation but markedly delayed insulin resistance after high fat feeding in rats .
26197708	0	fatty_acid	28,38	fat	140,143	fatty acid	fat	CHEBI:35366	29184(Tax:10116)	Chemical	Gene	transport|amod|START_ENTITY increase|nmod|transport delayed|nsubj|increase delayed|nmod|feeding feeding|amod|END_ENTITY	Extremely rapid increase in fatty_acid transport and intramyocellular lipid accumulation but markedly delayed insulin resistance after high fat feeding in rats .
22678998	0	fatty_acid	67,77	ghrelin	113,120	fatty acid	ghrelin	CHEBI:35366	58991(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Postprandial inhibition of gastric ghrelin secretion by long-chain fatty_acid through GPR120 in isolated gastric ghrelin cells and mice .
22678998	0	fatty_acid	67,77	ghrelin	35,42	fatty acid	ghrelin	CHEBI:35366	58991(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|inhibition inhibition|nmod|secretion secretion|compound|END_ENTITY	Postprandial inhibition of gastric ghrelin secretion by long-chain fatty_acid through GPR120 in isolated gastric ghrelin cells and mice .
23680429	0	fatty_acid	43,53	ghrelin	32,39	fatty acid	ghrelin	CHEBI:35366	59301(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY effects|nmod|metabolism effects|nmod|END_ENTITY	Differential effects of central ghrelin on fatty_acid metabolism in hypothalamic ventral medial and arcuate nuclei .
8138047	0	fatty_acid	19,29	glycerophosphate_acyltransferase	45,77	fatty acid	glycerophosphate acyltransferase	CHEBI:35366	29653(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effects of dietary fatty_acid composition on glycerophosphate_acyltransferase activity in rat adipose tissue and liver .
11130294	0	fatty_acid	64,74	growth_hormone	11,25	fatty acid	growth hormone	CHEBI:35366	2688	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|treatment treatment|amod|END_ENTITY	Effects of growth_hormone treatment on red cell plasma membrane fatty_acid constituents in hypopituitary adults .
12423628	0	fatty_acid	37,47	growth_hormone	86,100	fatty acid	growth hormone	CHEBI:35366	2688	Chemical	Gene	levels|amod|START_ENTITY circulating|dobj|levels lowering|advcl|circulating Effects|acl|lowering END_ENTITY|nsubj|Effects	Effects of lowering circulating free fatty_acid levels on protein metabolism in adult growth_hormone deficient patients .
12679475	0	fatty_acid	51,61	growth_hormone	10,24	fatty acid	growth hormone	CHEBI:35366	2688	Chemical	Gene	metabolism|amod|START_ENTITY Effect|nmod|metabolism Effect|nmod|END_ENTITY	Effect of growth_hormone -LRB- GH -RRB- on glycerol and free fatty_acid metabolism during exhaustive exercise in GH-deficient adults .
2001235	0	fatty_acid	14,24	growth_hormone	59,73	fatty acid	growth hormone	CHEBI:35366	443329(Tax:9940)	Chemical	Gene	metabolism|amod|START_ENTITY Regulation|nmod|metabolism Regulation|nmod|END_ENTITY	Regulation of fatty_acid metabolism and gluconeogenesis by growth_hormone and insulin in sheep hepatocyte cultures .
2462524	0	fatty_acid	132,142	growth_hormone	165,179	fatty acid	growth hormone	CHEBI:35366	2688	Chemical	Gene	binding|amod|START_ENTITY genes|amod|binding genes|compound|END_ENTITY	Mechanisms underlying generation of gradients in gene expression within the intestine : an analysis using transgenic_mice containing fatty_acid binding protein-human growth_hormone fusion genes .
2888799	0	fatty_acid	14,24	growth_hormone	37,51	fatty acid	growth hormone	CHEBI:35366	443329(Tax:9940)	Chemical	Gene	infusion|amod|START_ENTITY infusion|nmod|secretion secretion|amod|END_ENTITY	The effect of fatty_acid infusion on growth_hormone secretion in the ovine fetus : evidence for immaturity of pituitary responsiveness in utero .
3355851	0	fatty_acid	19,29	growth_hormone	114,128	fatty acid	growth hormone	CHEBI:35366	81668(Tax:10116)	Chemical	Gene	composition|amod|START_ENTITY differences|nmod|composition regulated|nsubjpass|differences regulated|nmod|pattern pattern|nmod|END_ENTITY	Sex differences in fatty_acid composition of rat liver phosphatidylcholine are regulated by the plasma pattern of growth_hormone .
3707134	0	fatty_acid	28,38	growth_hormone	10,24	fatty acid	growth hormone	CHEBI:35366	81668(Tax:10116)	Chemical	Gene	oxidation|amod|START_ENTITY END_ENTITY|nmod|oxidation	Effect of growth_hormone on fatty_acid oxidation : growth_hormone increases the activity of 2,4-dienoyl-CoA reductase in mitochondria .
3707134	0	fatty_acid	28,38	growth_hormone	50,64	fatty acid	growth hormone	CHEBI:35366	81668(Tax:10116)	Chemical	Gene	oxidation|amod|START_ENTITY growth_hormone|nmod|oxidation Effect|nmod|growth_hormone Effect|dep|increases increases|amod|END_ENTITY	Effect of growth_hormone on fatty_acid oxidation : growth_hormone increases the activity of 2,4-dienoyl-CoA reductase in mitochondria .
5837785	0	fatty_acid	108,118	growth_hormone	47,61	fatty acid	growth hormone	CHEBI:35366	81668(Tax:10116)	Chemical	Gene	degradation|amod|START_ENTITY involved|nmod|degradation effect|acl|involved effect|nmod|END_ENTITY	The effect of treatment of rats with pituitary growth_hormone on the activities of some enzymes involved in fatty_acid degradation and synthesis .
7262838	0	fatty_acid	5,15	growth_hormone	47,61	fatty acid	growth hormone	CHEBI:35366	2688	Chemical	Gene	START_ENTITY|dobj|inhibition inhibition|nmod|secretion secretion|compound|END_ENTITY	Free fatty_acid inhibition of exercise-induced growth_hormone secretion .
7476342	0	fatty_acid	106,116	growth_hormone	21,35	fatty acid	growth hormone	CHEBI:35366	2688	Chemical	Gene	levels|amod|START_ENTITY decreasing|dobj|levels potentiates|advcl|decreasing potentiates|dobj|response response|amod|END_ENTITY	Acipimox potentiates growth_hormone response to growth_hormone-releasing hormone by decreasing serum free fatty_acid levels in hyperthyroidism .
7607610	0	fatty_acid	47,57	growth_hormone	10,24	fatty acid	growth hormone	CHEBI:35366	2688	Chemical	Gene	composition|amod|START_ENTITY Effect|nmod|composition Effect|nmod|administration administration|amod|END_ENTITY	Effect of growth_hormone administration on the fatty_acid composition of adipose tissue in growth-hormone-deficient men .
7629249	0	fatty_acid	128,138	growth_hormone	21,35	fatty acid	growth hormone	CHEBI:35366	2688	Chemical	Gene	lowering|dobj|START_ENTITY potentiates|advcl|lowering potentiates|dobj|response response|amod|END_ENTITY	Acipimox potentiates growth_hormone -LRB- GH -RRB- response to GH-releasing hormone with or without pyridostigmine by lowering serum free fatty_acid in normal and obese subjects .
7665372	0	fatty_acid	17,27	growth_hormone	42,56	fatty acid	growth hormone	CHEBI:35366	2688	Chemical	Gene	modulation|amod|START_ENTITY modulation|nmod|hormone hormone|amod|END_ENTITY	Glucose and free fatty_acid modulation of growth_hormone and luteinizing hormone secretion by cultured porcine pituitary cells .
8505324	0	fatty_acid	59,69	growth_hormone	92,106	fatty acid	growth hormone	CHEBI:35366	2688	Chemical	Gene	START_ENTITY|dobj|genes genes|compound|END_ENTITY	Comparison of the patterns of expression of rat intestinal fatty_acid binding protein/human growth_hormone fusion genes in cultured intestinal epithelial cell lines and in the gut epithelium of transgenic_mice .
8622602	0	fatty_acid	134,144	growth_hormone	49,63	fatty acid	growth hormone	CHEBI:35366	2688	Chemical	Gene	serum|acl|START_ENTITY growth_hormone-releasing_hormone|nmod|serum response|acl|growth_hormone-releasing_hormone response|amod|END_ENTITY	Long-term administration of acipimox potentiates growth_hormone response to growth_hormone-releasing_hormone by decreasing serum free fatty_acid in obesity .
8772549	0	fatty_acid	30,40	growth_hormone	70,84	fatty acid	growth hormone	CHEBI:35366	2688	Chemical	Gene	START_ENTITY|ccomp|stimulates stimulates|dobj|secretion secretion|amod|END_ENTITY	Acipimox-mediated plasma free fatty_acid depression per se stimulates growth_hormone -LRB- GH -RRB- secretion in normal subjects and potentiates the response to other GH-releasing stimuli .
8772550	0	fatty_acid	107,117	growth_hormone	9,23	fatty acid	growth hormone	CHEBI:35366	2688	Chemical	Gene	depression|compound|START_ENTITY reversed|nmod|depression reversed|nsubjpass|secretion secretion|compound|END_ENTITY	Impaired growth_hormone secretion in obese subjects is partially reversed by acipimox-mediated plasma free fatty_acid depression .
9832417	0	fatty_acid	37,47	growth_hormone	51,65	fatty acid	growth hormone	CHEBI:35366	443329(Tax:9940)	Chemical	Gene	action|nmod|START_ENTITY mediated|dobj|action mediated|nmod|secretion secretion|amod|END_ENTITY	Hypothalamic mediated action of free fatty_acid on growth_hormone secretion in sheep .
11404143	0	fatty_acid	11,21	hFABP	39,44	fatty acid	hFABP	CHEBI:35366	2170	Chemical	Gene	START_ENTITY|dobj|protein protein|appos|END_ENTITY	Heart-type fatty_acid binding protein -LRB- hFABP -RRB- in the diagnosis of myocardial_damage in coronary artery bypass grafting .
26072112	0	fatty_acid	30,40	hFABP	58,63	fatty acid	hFABP	CHEBI:35366	2170	Chemical	Gene	START_ENTITY|dobj|protein protein|appos|END_ENTITY	Ischemic biomarker heart-type fatty_acid binding protein -LRB- hFABP -RRB- in acute_heart_failure - diagnostic and prognostic insights compared to NT-proBNP and troponin I. BACKGROUND : To evaluate diagnostic and long-term prognostic values of hFABP compared to NT-proBNP and troponin I -LRB- TnI -RRB- in patients presenting to the emergency_department -LRB- ED -RRB- suspected of acute_heart_failure -LRB- AHF -RRB- .
21856370	0	fatty_acid	12,22	hFABP1	40,46	fatty acid	hFABP1	CHEBI:35366	2168	Chemical	Gene	binding|amod|START_ENTITY gene|amod|binding gene|appos|END_ENTITY	Human liver fatty_acid binding protein -LRB- hFABP1 -RRB- gene is regulated by liver-enriched transcription factors HNF3b and C/EBPa .
17343826	0	fatty_acid	21,31	hFABP2	49,55	fatty acid	hFABP2	CHEBI:35366	2169	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The human intestinal fatty_acid binding protein -LRB- hFABP2 -RRB- gene is regulated by HNF-4alpha .
20709966	0	fatty_acid	88,98	heart-type_fatty_acid-binding_protein	22,59	fatty acid	heart-type fatty acid-binding protein	CHEBI:35366	419557(Tax:9031)	Chemical	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification of the heart-type_fatty_acid-binding_protein as a major gene for chicken fatty_acid metabolism by Bayesian network analysis .
1030170	0	fatty_acid	121,131	insulin	145,152	fatty acid	insulin	CHEBI:35366	483665(Tax:9615)	Chemical	Gene	START_ENTITY|nmod|-RSB- -RSB-|nmod:poss|author author|compound|END_ENTITY	Effects of thyroid-stimulating hormone upon the regulation of serum insulin levels and on the blood sugar and serum free fatty_acid responses to insulin -LSB- author 's transl -RSB- .
1030170	0	fatty_acid	121,131	insulin	68,75	fatty acid	insulin	CHEBI:35366	483665(Tax:9615)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|hormone hormone|nmod|regulation regulation|nmod|levels levels|compound|END_ENTITY	Effects of thyroid-stimulating hormone upon the regulation of serum insulin levels and on the blood sugar and serum free fatty_acid responses to insulin -LSB- author 's transl -RSB- .
10690936	0	fatty_acid	34,44	insulin	104,111	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	concentrations|amod|START_ENTITY regulation|nmod|concentrations abnormal|nsubj|regulation abnormal|nmod|subjects subjects|nmod|resistance resistance|compound|END_ENTITY	Insulin regulation of plasma free fatty_acid concentrations is abnormal in healthy subjects with muscle insulin resistance .
10804328	0	fatty_acid	69,79	insulin	90,97	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	levels|amod|START_ENTITY non-esterified|dobj|levels non-esterified|nmod|secretion secretion|compound|END_ENTITY	Lack of effect of a physiological elevation of plasma non-esterified fatty_acid levels on insulin secretion .
11015611	0	fatty_acid	44,54	insulin	97,104	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	gene|amod|START_ENTITY regulation|nmod|gene regulation|dep|interaction interaction|nmod|END_ENTITY	Transcriptional regulation of the adipocyte fatty_acid synthase gene by agouti : interaction with insulin .
11172473	0	fatty_acid	123,133	insulin	22,29	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	circulating|dobj|START_ENTITY relationship|acl|circulating relationship|dep|circulating circulating|dobj|concentrations concentrations|compound|END_ENTITY	Irregular circulating insulin concentrations in type_2_diabetes_mellitus : an inverse relationship between circulating free fatty_acid and the disorderliness of an insulin time series in diabetic and healthy individuals .
11507681	0	fatty_acid	24,34	insulin	93,100	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	suppression|amod|START_ENTITY associated|nsubjpass|suppression associated|nmod|endothelial_dysfunction endothelial_dysfunction|nmod|subjects subjects|compound|END_ENTITY	Impaired non-esterified fatty_acid suppression is associated with endothelial_dysfunction in insulin resistant subjects .
1199269	0	fatty_acid	39,49	insulin	14,21	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	metabolism|amod|START_ENTITY Secretion|nmod|metabolism Secretion|nmod|END_ENTITY	-LSB- Secretion of insulin and disorders in fatty_acid metabolism in diabetic patients with coronary_heart_diseases -RSB- .
12600851	0	fatty_acid	140,150	insulin	105,112	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	START_ENTITY|nsubj|effect effect|acl|varying varying|dobj|source source|acl|carbohydrate carbohydrate|nmod|glucose glucose|appos|END_ENTITY	Long-term effect of varying the source or amount of dietary carbohydrate on postprandial plasma glucose , insulin , triacylglycerol , and free fatty_acid concentrations in subjects with impaired_glucose_tolerance .
15352999	0	fatty_acid	107,117	insulin	19,26	fatty acid	insulin	CHEBI:35366	105613195	Chemical	Gene	concentrations|amod|START_ENTITY non-esterified|dobj|concentrations non-esterified|nsubj|response response|compound|END_ENTITY	Glucose-stimulated insulin response in pregnant sheep following acute suppression of plasma non-esterified fatty_acid concentrations .
15448091	0	fatty_acid	56,66	insulin	81,88	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|secretion secretion|compound|END_ENTITY	Evidence against the involvement of oxidative stress in fatty_acid inhibition of insulin secretion .
15677505	0	fatty_acid	122,132	insulin	144,151	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	effects|amod|START_ENTITY mediates|dobj|effects mediates|nmod|secretion secretion|compound|END_ENTITY	Fatty_acid translocase -LRB- FAT/CD36 -RRB- is localized on insulin-containing granules in human pancreatic beta-cells and mediates fatty_acid effects on insulin secretion .
156932	0	fatty_acid	39,49	insulin	7,14	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	changes|amod|START_ENTITY END_ENTITY|appos|changes	Plasma insulin , carbohydrate , and free fatty_acid changes in newly born infants of diabetic and non-diabetic mothers after loading with glucose , _ fructose , _ and_galactose .
15940468	0	fatty_acid	24,34	insulin	167,174	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	suppression|amod|START_ENTITY Impaired|dobj|suppression Impaired|nsubj|postpartum postpartum|dep|role role|nmod|secretion secretion|compound|END_ENTITY	Impaired non-esterified fatty_acid suppression to intravenous glucose during late pregnancy persists postpartum in gestational diabetes : a dominant role for decreased insulin secretion rather than insulin resistance .
15940468	0	fatty_acid	24,34	insulin	197,204	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	suppression|amod|START_ENTITY Impaired|dobj|suppression Impaired|nsubj|postpartum postpartum|dep|role role|nmod|secretion secretion|nmod|resistance resistance|compound|END_ENTITY	Impaired non-esterified fatty_acid suppression to intravenous glucose during late pregnancy persists postpartum in gestational diabetes : a dominant role for decreased insulin secretion rather than insulin resistance .
16128592	0	fatty_acid	198,208	insulin	217,224	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	resistance|amod|START_ENTITY resistance|compound|END_ENTITY	Submicromolar concentrations of palmitoyl-CoA specifically thioesterify_cysteine 244 in glyceraldehyde-3-phosphate_dehydrogenase inhibiting enzyme activity : a novel mechanism potentially underlying fatty_acid induced insulin resistance .
1677322	0	fatty_acid	29,39	insulin	70,77	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	concentration|amod|START_ENTITY concentration|nmod|END_ENTITY	Regulation of non-esterified fatty_acid and glycerol concentration by insulin in normal individuals and patients with type 2 diabetes .
16865295	0	fatty_acid	154,164	insulin	21,28	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	composition|amod|START_ENTITY role|nmod|composition patients|dep|role blunted|nmod|patients blunted|nsubjpass|effect effect|nmod|END_ENTITY	Inhibitory effect of insulin on vasopressin-induced intracellular calcium response is blunted in hyperinsulinemic hypertensive patients : role of membrane fatty_acid composition .
16981831	0	fatty_acid	4,14	insulin	61,68	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	pathway|amod|START_ENTITY pathway|nmod|resistance resistance|compound|END_ENTITY	The fatty_acid oxidation pathway as a therapeutic target for insulin resistance .
17045185	0	fatty_acid	26,36	insulin	126,133	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	uptake|amod|START_ENTITY uptake|dep|evidence evidence|nmod|relationship relationship|nmod|resistance resistance|compound|END_ENTITY	Decreased myocardial free fatty_acid uptake in patients with idiopathic_dilated_cardiomyopathy : evidence of relationship with insulin resistance and left_ventricular_dysfunction .
180975	1	fatty_acid	140,150	insulin	77,84	fatty acid	insulin	CHEBI:35366	100009181(Tax:9986)	Chemical	Gene	synthetase|amod|START_ENTITY turnover|nmod|synthetase controlling|dobj|turnover Interactions|acl|controlling Interactions|nmod|END_ENTITY	Interactions of insulin , prolactin and cortisol in controlling the turnover of fatty_acid synthetase in rabbit mammary gland in organ culture .
18801860	0	fatty_acid	45,55	insulin	16,23	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	metabolism|amod|START_ENTITY roles|nmod|metabolism resistance|dep|roles resistance|compound|END_ENTITY	Skeletal muscle insulin resistance : roles of fatty_acid metabolism and exercise .
18835976	0	fatty_acid	34,44	insulin	139,146	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	concentration|compound|START_ENTITY Incorporation|nmod|concentration improves|nsubj|Incorporation improves|nmod|sensitivity sensitivity|compound|END_ENTITY	Incorporation of the fasting free fatty_acid concentration into quantitative insulin sensitivity check index improves its association with insulin sensitivity in adults , but not in children .
18835976	0	fatty_acid	34,44	insulin	77,84	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	concentration|compound|START_ENTITY concentration|nmod|index index|compound|END_ENTITY	Incorporation of the fasting free fatty_acid concentration into quantitative insulin sensitivity check index improves its association with insulin sensitivity in adults , but not in children .
18957499	0	fatty_acid	36,46	insulin	66,73	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	START_ENTITY|dobj|resistance resistance|compound|END_ENTITY	Effect of weight_loss on liver free fatty_acid uptake and hepatic insulin resistance .
1905151	0	fatty_acid	5,15	insulin	128,135	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Free fatty_acid accumulation in secretagogue-stimulated pancreatic islets and effects of arachidonate on depolarization-induced insulin secretion .
19573960	0	fatty_acid	103,113	insulin	144,151	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	START_ENTITY|dobj|composition composition|nmod|resistance resistance|compound|END_ENTITY	Influence of an eicosapentaenoic and docosahexaenoic_acid-enriched enteral nutrition formula on plasma fatty_acid composition and biomarkers of insulin resistance in the elderly .
19822001	0	fatty_acid	27,37	insulin	111,118	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	START_ENTITY|ccomp|reduces reduces|iobj|END_ENTITY	A high oleic sunflower oil fatty_acid esters of plant sterols mixed with dietary diacylglycerol reduces plasma insulin and body fat accumulation in Psammomys obesus .
20299470	0	fatty_acid	14,24	insulin	69,76	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	synthase|amod|START_ENTITY synthase|dep|biomarker biomarker|nmod|resistance resistance|compound|END_ENTITY	Extracellular fatty_acid synthase : a possible surrogate biomarker of insulin resistance .
20460954	0	fatty_acid	46,56	insulin	64,71	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	Relationship of adipokines and non-esterified fatty_acid to the insulin resistance in non-diabetic individuals .
20811782	0	fatty_acid	37,47	insulin	14,21	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of insulin and T3-induced fatty_acid synthase by hexanoate .
21973241	0	fatty_acid	73,83	insulin	240,247	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	START_ENTITY|dobj|evidence evidence|nmod|effects effects|nmod|secretion secretion|compound|END_ENTITY	Twenty-four-hour profiles of plasma glucose , insulin , C-peptide and free fatty_acid in subjects with varying degrees of glucose_tolerance following short-term , medium-dose prednisone -LRB- 20 mg/day -RRB- treatment : evidence for differing effects on insulin secretion and action .
21973241	0	fatty_acid	73,83	insulin	45,52	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	START_ENTITY|nsubj|profiles profiles|nmod|glucose glucose|appos|END_ENTITY	Twenty-four-hour profiles of plasma glucose , insulin , C-peptide and free fatty_acid in subjects with varying degrees of glucose_tolerance following short-term , medium-dose prednisone -LRB- 20 mg/day -RRB- treatment : evidence for differing effects on insulin secretion and action .
22125617	0	fatty_acid	42,52	insulin	108,115	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	START_ENTITY|ccomp|contribute contribute|nmod|resistance resistance|compound|END_ENTITY	Coordinated_defects in hepatic long chain fatty_acid metabolism and triglyceride accumulation contribute to insulin resistance in non-human primates .
22221293	0	fatty_acid	37,47	insulin	80,87	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	START_ENTITY|nmod|deterioration deterioration|nmod|secretion secretion|compound|END_ENTITY	Effect of exposure to non-esterified fatty_acid on progressive deterioration of insulin secretion in patients with Type 2 diabetes : a long-term follow-up study .
22336648	0	fatty_acid	10,20	insulin	84,91	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	START_ENTITY|dobj|protein protein|nmod|indicators indicators|nmod|development development|compound|END_ENTITY	Adipocyte fatty_acid binding protein and C-reactive_protein levels as indicators of insulin resistance development .
22459825	0	fatty_acid	47,57	insulin	22,29	fatty acid	insulin	CHEBI:35366	280829(Tax:9913)	Chemical	Gene	concentration|xcomp|START_ENTITY concentration|nsubj|Association Association|nmod|END_ENTITY	Association of plasma insulin concentration to fatty_acid distribution between milk fat and membrane synthesis .
22740706	0	fatty_acid	27,37	insulin	71,78	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	levels|amod|START_ENTITY plasma|dep|levels associated|nsubjpass|plasma associated|nmod|secretion secretion|compound|END_ENTITY	Higher fasting plasma free fatty_acid levels are associated with lower insulin secretion in children and adults and a higher incidence of type_2_diabetes .
22999246	0	fatty_acid	11,21	insulin	68,75	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	START_ENTITY|nmod|setting setting|nmod|resistance resistance|compound|END_ENTITY	Myocardial fatty_acid metabolism and lipotoxicity in the setting of insulin resistance .
23378609	0	fatty_acid	16,26	insulin	78,85	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	receptor|amod|START_ENTITY Reevaluation|nmod|receptor target|nsubj|Reevaluation target|nmod|stimulation stimulation|nmod|secretion secretion|compound|END_ENTITY	Reevaluation of fatty_acid receptor 1 as a drug target for the stimulation of insulin secretion in humans .
23517921	0	fatty_acid	10,20	insulin	52,59	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	intakes|nsubj|START_ENTITY intakes|nmod|resistance resistance|compound|END_ENTITY	Total n-3 fatty_acid and SFA intakes in relation to insulin resistance in a Canadian First Nation at risk for the development of type 2 diabetes .
23646039	0	fatty_acid	5,15	insulin	29,36	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	Free fatty_acid oxidation in insulin resistance and obesity .
24378016	0	fatty_acid	53,63	insulin	127,134	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	Treatment with omega-3_fatty_acid_ethyl-ester alters fatty_acid composition of lipoproteins in overweight or obese adults with insulin resistance .
2465000	0	fatty_acid	58,68	insulin	9,16	fatty acid	insulin	CHEBI:35366	105613195	Chemical	Gene	synthesis|amod|START_ENTITY adaptations|nmod|synthesis Roles|nmod|adaptations Roles|nmod|END_ENTITY	Roles of insulin and growth_hormone in the adaptations of fatty_acid synthesis in white adipose tissue during the lactation cycle in sheep .
24675078	0	fatty_acid	114,124	insulin	141,148	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	potentiation|amod|START_ENTITY potentiation|nmod|secretion secretion|compound|END_ENTITY	Increased glucose metabolism and glycerolipid formation by fatty_acids and GPR40 receptor signaling underlies the fatty_acid potentiation of insulin secretion .
24914633	0	fatty_acid	6,16	insulin	95,102	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	Serum|acl|START_ENTITY provides|nsubj|Serum provides|dobj|indicator indicator|nmod|resistance resistance|compound|END_ENTITY	Serum fatty_acid profiling within distinct lipid fractions provides a more robust indicator of insulin resistance in humans than total triglyceride and fatty_acid profiles .
24944906	0	fatty_acid	18,28	insulin	78,85	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	protein|amod|START_ENTITY Identification|nmod|protein Identification|dep|as as|dep|adipokine adipokine|acl:relcl|regulates regulates|dobj|secretion secretion|compound|END_ENTITY	Identification of fatty_acid binding protein 4 as an adipokine that regulates insulin secretion during obesity .
2676896	0	fatty_acid	10,20	insulin	36,43	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	composition|amod|START_ENTITY composition|nmod|END_ENTITY	Effect of fatty_acid composition on insulin and IGF-I binding in retinoblastoma cells .
2691123	0	fatty_acid	82,92	insulin	59,66	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	metabolism|amod|START_ENTITY sensitivity|nmod|metabolism sensitivity|compound|END_ENTITY	Use of combined oral contraceptive preparations alters the insulin sensitivity of fatty_acid and ketone metabolism .
3517028	0	fatty_acid	98,108	insulin	46,53	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|differences differences|nmod|glucose_tolerance glucose_tolerance|nmod|ability ability|nmod:poss|END_ENTITY	Effect of differences in glucose_tolerance on insulin 's ability to regulate carbohydrate and free fatty_acid metabolism in obese individuals .
3553852	0	fatty_acid	24,34	insulin	59,66	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	levels|amod|START_ENTITY elevation|nmod|levels leads|nsubj|elevation leads|nmod|resistance resistance|compound|END_ENTITY	Acute elevation of free fatty_acid levels leads to hepatic insulin resistance in obese subjects .
3803743	0	fatty_acid	92,102	insulin	59,66	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	START_ENTITY|nsubj|Improvement Improvement|nmod|control control|nmod|changes changes|compound|END_ENTITY	Improvement of diabetic control by continuous subcutaneous insulin infusion therapy changes fatty_acid composition of serum lipids and erythrocytes in type 1 -LRB- insulin-dependent -RRB- diabetes .
3900120	0	fatty_acid	20,30	insulin	102,109	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	concentrations|amod|START_ENTITY concentrations|dep|evidence evidence|nmod|resistance resistance|compound|END_ENTITY	Ambient plasma free fatty_acid concentrations in noninsulin-dependent_diabetes_mellitus : evidence for insulin resistance .
6751811	0	fatty_acid	35,45	insulin	11,18	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	synthesis|amod|START_ENTITY Effects|nmod|synthesis Effects|nmod|END_ENTITY	Effects of insulin and glucagon on fatty_acid synthesis from acetate by hepatocytes incubated with -LRB----RRB- - hydroxycitrate .
6756006	0	fatty_acid	94,104	insulin	56,63	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	concentrations|amod|START_ENTITY control|dobj|concentrations control|nmod|administration administration|compound|END_ENTITY	Effect of prolonged optimal blood sugar control by i.v. insulin administration on plasma free fatty_acid and glycerol concentrations of insulin-dependent diabetics during exercise .
7021276	0	fatty_acid	94,104	insulin	38,45	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|infusion infusion|compound|END_ENTITY	The effects of a low-dose intravenous insulin infusion upon plasma glucose and non-esterified fatty_acid levels in very_obese_and_non-obese human subjects .
8061346	0	fatty_acid	44,54	insulin	93,100	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	autonomic_neuropathy|nmod|START_ENTITY Effects|nmod|autonomic_neuropathy metabolism|nsubj|Effects metabolism|dobj|withdrawal withdrawal|compound|END_ENTITY	Effects of autonomic_neuropathy on glucose , fatty_acid , and ketone body metabolism following insulin withdrawal in patients with insulin-dependent_diabetes .
8243430	0	fatty_acid	68,78	insulin	51,58	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Acute effects of graded alcohol intake on glucose , insulin and free fatty_acid levels in non-insulin-dependent diabetic subjects .
8582538	0	fatty_acid	41,51	insulin	64,71	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	infusion|amod|START_ENTITY infusion|nmod|secretion secretion|compound|END_ENTITY	Opposite effects of short - and long-term fatty_acid infusion on insulin secretion in healthy subjects .
9012639	0	fatty_acid	43,53	insulin	15,22	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	levels|amod|START_ENTITY Differences|nmod|levels Differences|nmod|suppression suppression|compound|END_ENTITY	Differences in insulin suppression of free fatty_acid levels by gender and glucose tolerance status .
9108790	0	fatty_acid	29,39	insulin	11,18	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	metabolism|amod|START_ENTITY Defects|nmod|metabolism Defects|nmod|action action|compound|END_ENTITY	Defects of insulin action on fatty_acid and carbohydrate metabolism in familial combined hyperlipidemia .
961625	0	fatty_acid	36,46	insulin	22,29	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	responses|amod|START_ENTITY free|dobj|responses free|nsubj|glucose glucose|appos|END_ENTITY	Postprandial glucose , insulin , free fatty_acid and growth_hormone responses in children consuming all the day 's protein in one meal .
9844992	0	fatty_acid	52,62	insulin	28,35	fatty acid	insulin	CHEBI:35366	3630	Chemical	Gene	START_ENTITY|nsubj|Relationship Relationship|nmod|END_ENTITY	Relationship between plasma insulin and erythrocyte fatty_acid composition .
18682535	0	fatty_acid	22,32	insulin_and_T3	45,59	fatty acid	insulin and T3	CHEBI:35366	3630;292	Chemical	Gene	synthase|amod|START_ENTITY synthase|nmod|END_ENTITY	Hepatic regulation of fatty_acid synthase by insulin_and_T3 : evidence for T3 genomic and nongenomic actions .
14517348	0	fatty_acid	60,70	interferon_gamma	14,30	fatty acid	interferon gamma	CHEBI:35366	3458	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of interferon_gamma signaling by the short chain fatty_acid butyrate .
8466918	0	fatty_acid	11,21	interphotoreceptor_retinoid-binding_protein	38,81	fatty acid	interphotoreceptor retinoid-binding protein	CHEBI:35366	5949	Chemical	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Study of a fatty_acid binding site of interphotoreceptor_retinoid-binding_protein using fluorescent fatty_acids .
16254517	0	fatty_acid	12,22	intestinal_trefoil_factor	92,117	fatty acid	intestinal trefoil factor	CHEBI:35366	25563(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Short-chain fatty_acid induces intestinal mucosal_injury in newborn rats and down-regulates intestinal_trefoil_factor gene expression in vivo and in vitro .
26305484	0	fatty_acid	22,32	irisin	57,63	fatty acid	irisin	CHEBI:35366	252995	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Association of plasma fatty_acid composition with plasma irisin levels in normal weight and overweight/obese children .
26305484	0	fatty_acid	22,32	irisin	57,63	fatty acid	irisin	CHEBI:35366	252995	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Association of plasma fatty_acid composition with plasma irisin levels in normal weight and overweight/obese children .
10051641	0	fatty_acid	14,24	leptin	61,67	fatty acid	leptin	CHEBI:35366	25608(Tax:10116)	Chemical	Gene	homeostasis|amod|START_ENTITY Regulation|nmod|homeostasis Regulation|dep|role role|nmod|END_ENTITY	Regulation of fatty_acid homeostasis in cells : novel role of leptin .
10919937	0	fatty_acid	137,147	leptin	98,104	fatty acid	leptin	CHEBI:35366	3952	Chemical	Gene	disposal|amod|START_ENTITY pattern|nmod|disposal END_ENTITY|nmod|pattern	An endocrine and metabolic definition of the intermeal interval in humans : evidence for a role of leptin on the prandial pattern through fatty_acid disposal .
11254747	0	fatty_acid	19,29	leptin	57,63	fatty acid	leptin	CHEBI:35366	25608(Tax:10116)	Chemical	Gene	deficiency|amod|START_ENTITY depresses|nsubj|deficiency depresses|dobj|levels levels|compound|END_ENTITY	Maternal essential fatty_acid deficiency depresses serum leptin levels in suckling rat pups .
11404229	0	fatty_acid	56,66	leptin	23,29	fatty acid	leptin	CHEBI:35366	3952	Chemical	Gene	metabolism|amod|START_ENTITY contraction|nmod|metabolism contraction|compound|END_ENTITY	Stimulatory effects of leptin and muscle contraction on fatty_acid metabolism are not additive .
11729182	0	fatty_acid	40,50	leptin	8,14	fatty acid	leptin	CHEBI:35366	25608(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|decreases decreases|compound|END_ENTITY	Chronic leptin administration decreases fatty_acid uptake and fatty_acid transporters in rat skeletal muscle .
14724075	0	fatty_acid	77,87	leptin	29,35	fatty acid	leptin	CHEBI:35366	25608(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY role|nmod|expression role|nmod|concentration concentration|compound|END_ENTITY	Potential role of high serum leptin concentration in age-related decrease of fatty_acid synthase gene expression in rat white adipose tissue .
15590268	0	fatty_acid	67,77	leptin	24,30	fatty acid	leptin	CHEBI:35366	25608(Tax:10116)	Chemical	Gene	intermediates|amod|START_ENTITY role|nmod|intermediates regulation|dep|role regulation|nmod|production production|compound|END_ENTITY	Metabolic regulation of leptin production in adipocytes : a role of fatty_acid synthesis intermediates .
15650121	0	fatty_acid	17,27	leptin	38,44	fatty acid	leptin	CHEBI:35366	25608(Tax:10116)	Chemical	Gene	secretion|compound|START_ENTITY secretion|compound|END_ENTITY	Eicosapentaenoic fatty_acid increases leptin secretion from primary cultured rat adipocytes : role of glucose metabolism .
15941644	0	fatty_acid	40,50	leptin	18,24	fatty acid	leptin	CHEBI:35366	373955(Tax:9031)	Chemical	Gene	expression|amod|START_ENTITY role|nmod|expression role|nmod|END_ENTITY	Potential role of leptin in increase of fatty_acid synthase gene expression in chicken liver .
16299415	0	fatty_acid	71,81	leptin	42,48	fatty acid	leptin	CHEBI:35366	25608(Tax:10116)	Chemical	Gene	concentrations|compound|START_ENTITY concentrations|compound|adiponectin adiponectin|compound|END_ENTITY	Effects of fasting and refeeding on serum leptin , adiponectin and free fatty_acid concentrations in young and old male rats .
17479441	0	fatty_acid	44,54	leptin	20,26	fatty acid	leptin	CHEBI:35366	25608(Tax:10116)	Chemical	Gene	oxidation|amod|START_ENTITY action|nmod|oxidation action|nmod|END_ENTITY	Concerted action of leptin in regulation of fatty_acid oxidation in skeletal muscle and liver .
20597887	0	fatty_acid	91,101	leptin	65,71	fatty acid	leptin	CHEBI:35366	280836(Tax:9913)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|supplementation supplementation|nmod|period period|nmod|END_ENTITY	Effect of fat supplementation during transition period on plasma leptin and non-esterified fatty_acid concentrations in Holstein cows .
23747566	0	fatty_acid	42,52	leptin	7,13	fatty acid	leptin	CHEBI:35366	105085360	Chemical	Gene	variations|compound|START_ENTITY variations|compound|glucose glucose|compound|END_ENTITY	Plasma leptin , glucose and non-esterified fatty_acid variations in dromedary camels exposed to prolonged periods of underfeeding or dehydration .
9177227	0	fatty_acid	59,69	leptin	13,19	fatty acid	leptin	CHEBI:35366	25608(Tax:10116)	Chemical	Gene	oxidation|amod|START_ENTITY Induction|nmod|oxidation Induction|nmod|END_ENTITY	Induction by leptin of uncoupling_protein-2 and enzymes of fatty_acid oxidation .
10588486	0	fatty_acid	30,40	lipoprotein_lipase	74,92	fatty acid	lipoprotein lipase	CHEBI:35366	4023	Chemical	Gene	Hydrolysis|nmod|START_ENTITY enriched|nsubj|Hydrolysis enriched|nmod|END_ENTITY	Hydrolysis of long-chain , n-3 fatty_acid enriched chylomicrons by cardiac lipoprotein_lipase .
11352185	0	fatty_acid	15,25	lipoprotein_lipase	53,71	fatty acid	lipoprotein lipase	CHEBI:35366	4023	Chemical	Gene	START_ENTITY|nmod|deficiency deficiency|amod|END_ENTITY	Adipose tissue fatty_acid composition in humans with lipoprotein_lipase deficiency .
14703506	0	fatty_acid	63,73	lipoprotein_lipase	21,39	fatty acid	lipoprotein lipase	CHEBI:35366	4023	Chemical	Gene	trapping|amod|START_ENTITY increasing|dobj|trapping enhances|advcl|increasing enhances|nmod|activity activity|compound|END_ENTITY	ASP enhances in situ lipoprotein_lipase activity by increasing fatty_acid trapping in adipocytes .
19033209	0	fatty_acid	14,24	lipoprotein_lipase	46,64	fatty acid	lipoprotein lipase	CHEBI:35366	4023	Chemical	Gene	Regulation|nmod|START_ENTITY uptake|nsubj|Regulation uptake|nmod|tissues tissues|dep|pathways pathways|amod|END_ENTITY	Regulation of fatty_acid uptake into tissues : lipoprotein_lipase - and CD36-mediated pathways .
22226882	0	fatty_acid	83,93	lipoprotein_lipase	8,26	fatty acid	lipoprotein lipase	CHEBI:35366	24539(Tax:10116)	Chemical	Gene	flux|amod|START_ENTITY regulated|nmod|flux regulated|nsubjpass|activity activity|compound|END_ENTITY	Cardiac lipoprotein_lipase activity in the hypertrophied heart may be regulated by fatty_acid flux .
23271120	0	fatty_acid	116,126	lipoprotein_lipase	70,88	fatty acid	lipoprotein lipase	CHEBI:35366	280843(Tax:9913)	Chemical	Gene	composition|amod|START_ENTITY associated|nmod|composition associated|nsubj|Identification Identification|nmod|polymorphisms polymorphisms|nmod|gene gene|amod|END_ENTITY	Identification of novel single nucleotide polymorphisms -LRB- SNPs -RRB- of the lipoprotein_lipase -LRB- LPL -RRB- gene associated with fatty_acid composition in Korean cattle .
9698281	0	fatty_acid	44,54	lipoprotein_lipase	24,42	fatty acid	lipoprotein lipase	CHEBI:35366	280843(Tax:9913)	Chemical	Gene	START_ENTITY|nsubj|RNAs RNAs|acl|encoding encoding|dobj|END_ENTITY	Messenger RNAs encoding lipoprotein_lipase , fatty_acid synthase and hormone-sensitive_lipase in the adipose_tissue of underfed-refed ewes and cows .
16263710	0	fatty_acid	47,57	long_chain_acyl-CoA_synthetase_5	4,36	fatty acid	long chain acyl-CoA synthetase 5	CHEBI:35366	94340(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|increases increases|amod|END_ENTITY	Rat long_chain_acyl-CoA_synthetase_5 increases fatty_acid uptake and partitioning to cellular triacylglycerol in McArdle-RH7777 cells .
18640380	0	fatty_acid	88,98	low-density_lipoprotein_receptor	110,142	fatty acid	low-density lipoprotein receptor	CHEBI:35366	16835(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Dietary alpha-cyclodextrin lowers low-density lipoprotein cholesterol and alters plasma fatty_acid profile in low-density_lipoprotein_receptor knockout mice on a high-fat diet .
23624629	0	fatty_acid	14,24	mTOR	39,43	fatty acid	mTOR	CHEBI:35366	21977(Tax:10090)	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|nmod|END_ENTITY	Regulation of fatty_acid metabolism by mTOR in adult murine hearts occurs independently of changes in PGC-1a .
24866893	0	fatty_acid	47,57	mTOR	4,8	fatty acid	mTOR	CHEBI:35366	21977(Tax:10090)	Chemical	Gene	inhibitor|amod|START_ENTITY synergizes|nmod|inhibitor synergizes|nsubj|rapamycin rapamycin|compound|END_ENTITY	The mTOR inhibitor rapamycin synergizes with a fatty_acid synthase inhibitor to induce cytotoxicity in ER/HER2-positive breast_cancer cells .
24918753	0	fatty_acid	132,142	mTOR	94,98	fatty acid	mTOR	CHEBI:35366	21977(Tax:10090)	Chemical	Gene	synthesis|amod|START_ENTITY signaling|dobj|synthesis END_ENTITY|acl|signaling	Alpha-2-glycoprotein 1 -LRB- AZGP1 -RRB- regulates biological behaviors of LoVo cells by down-regulating mTOR signaling pathway and endogenous fatty_acid synthesis .
25123131	0	fatty_acid	44,54	mTOR	128,132	fatty acid	mTOR	CHEBI:35366	21977(Tax:10090)	Chemical	Gene	eicosapentaenoic_acid-free|amod|START_ENTITY combination|nmod|eicosapentaenoic_acid-free has|nsubj|combination has|dobj|effect effect|nmod|END_ENTITY	A combination of eicosapentaenoic_acid-free fatty_acid , epigallocatechin-3-gallate and proanthocyanidins has a strong effect on mTOR signaling in colorectal_cancer cells .
10749714	0	fatty_acid	54,64	malonyl-CoA_decarboxylase	16,41	fatty acid	malonyl-CoA decarboxylase	CHEBI:35366	85239(Tax:10116)	Chemical	Gene	oxidation|amod|START_ENTITY END_ENTITY|nmod|oxidation	Contribution of malonyl-CoA_decarboxylase to the high fatty_acid oxidation rates seen in the diabetic heart .
12703623	0	fatty_acid	61,71	milk	56,60	fatty acid	milk	CHEBI:35366	100532204	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|combinations combinations|nmod|meal meal|nmod|END_ENTITY	Effect of combinations of fish meal and feather meal on milk fatty_acid content and nitrogen utilization in dairy cows .
14594230	0	fatty_acid	48,58	milk	43,47	fatty acid	milk	CHEBI:35366	100532204	Chemical	Gene	START_ENTITY|nsubj|Texture Texture|nmod|butter butter|nmod|cows cows|nmod|END_ENTITY	Texture of butter from cows with different milk fatty_acid compositions .
16223464	0	fatty_acid	65,75	milk	48,52	fatty acid	milk	CHEBI:35366	100532204	Chemical	Gene	composition|amod|START_ENTITY impact|nmod|composition Evaluation|dep|impact Evaluation|nmod|strategies strategies|acl|pumping pumping|nmod|END_ENTITY	Evaluation of cooling strategies for pumping of milk - impact of fatty_acid composition on free fatty_acid levels .
16223464	0	fatty_acid	96,106	milk	48,52	fatty acid	milk	CHEBI:35366	100532204	Chemical	Gene	levels|amod|START_ENTITY composition|nmod|levels impact|nmod|composition Evaluation|dep|impact Evaluation|nmod|strategies strategies|acl|pumping pumping|nmod|END_ENTITY	Evaluation of cooling strategies for pumping of milk - impact of fatty_acid composition on free fatty_acid levels .
18565932	0	fatty_acid	85,95	milk	60,64	fatty acid	milk	CHEBI:35366	100532204	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|silage silage|nmod|production production|compound|END_ENTITY	Effects of grass silage and soybean meal supplementation on milk production and milk fatty_acid profiles of grazing dairy cows .
20494167	0	fatty_acid	34,44	milk	60,64	fatty acid	milk	CHEBI:35366	100532204	Chemical	Gene	profile|amod|START_ENTITY profile|nmod|END_ENTITY	Flaxseed supplementation improves fatty_acid profile of cow milk .
22612917	0	fatty_acid	55,65	milk	95,99	fatty acid	milk	CHEBI:35366	100532204	Chemical	Gene	composition|amod|START_ENTITY composition|nmod|END_ENTITY	Effect of feeding fresh forage and marine algae on the fatty_acid composition and oxidation of milk and butter .
22901471	0	fatty_acid	45,55	milk	71,75	fatty acid	milk	CHEBI:35366	100532204	Chemical	Gene	composition|amod|START_ENTITY composition|nmod|END_ENTITY	Short communication : within-day variation in fatty_acid composition of milk from cows in an automatic milking system .
26627858	0	fatty_acid	85,95	milk	80,84	fatty acid	milk	CHEBI:35366	100532204	Chemical	Gene	composition|compound|START_ENTITY composition|compound|END_ENTITY	Feeding nitrate and docosahexaenoic_acid affects enteric methane production and milk fatty_acid composition in lactating dairy cows .
9566998	0	fatty_acid	8,18	milk	77,81	fatty acid	milk	CHEBI:35366	100532204	Chemical	Gene	sources|amod|START_ENTITY affect|nsubj|sources affect|dobj|concentrations concentrations|nmod|END_ENTITY	Dietary fatty_acid sources affect conjugated linoleic_acid concentrations in milk from lactating dairy cows .
18840435	0	fatty_acid	15,25	myoglobin	31,40	fatty acid	myoglobin	CHEBI:35366	4151	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of fatty_acid with myoglobin .
15664096	0	fatty_acid	21,31	neutral_endopeptidase	66,87	fatty acid	neutral endopeptidase	CHEBI:35366	4311	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|expression expression|amod|END_ENTITY	Antioxidants inhibit fatty_acid and glucose-mediated induction of neutral_endopeptidase gene expression in human microvascular endothelial cells .
10537216	0	fatty_acid	4,14	ole1	100,104	fatty acid	ole1	CHEBI:35366	852825(Tax:4932)	Chemical	Gene	genes|amod|START_ENTITY complement|nsubj|genes complement|dobj|mutation mutation|amod|END_ENTITY	Two fatty_acid delta9-desaturase genes , ole1 and ole2 , from Mortierella alpina complement the yeast ole1 mutation .
10537216	0	fatty_acid	4,14	ole1	40,44	fatty acid	ole1	CHEBI:35366	852825(Tax:4932)	Chemical	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Two fatty_acid delta9-desaturase genes , ole1 and ole2 , from Mortierella alpina complement the yeast ole1 mutation .
17227124	0	fatty_acid	39,49	p21	34,37	fatty acid	p21	CHEBI:35366	644914	Chemical	Gene	synthase|amod|START_ENTITY synthase|amod|END_ENTITY	Phosphorylated histone H3 , Ki-67 , p21 , fatty_acid synthase , and cleaved caspase-3 expression in benign and atypical granular_cell_tumors .
21283757	0	fatty_acid	32,42	p21	76,79	fatty acid	p21	CHEBI:35366	644914	Chemical	Gene	butyrate|compound|START_ENTITY targets|nsubj|butyrate targets|dobj|expression expression|amod|END_ENTITY	The microbe-derived short chain fatty_acid butyrate targets miRNA-dependent p21 gene expression in human colon_cancer .
27018864	0	fatty_acid	49,59	p_13	39,43	fatty acid	p 13	CHEBI:35366	440926	Chemical	Gene	protein|amod|START_ENTITY protein|nsubj|END_ENTITY	The minor house_dust_mite allergen Der p_13 is a fatty_acid binding protein and an activator of a TLR2-mediated innate immune response .
10391144	0	fatty_acid	22,32	peroxisome_proliferator-activated_receptor-alpha	75,123	fatty acid	peroxisome proliferator-activated receptor-alpha	CHEBI:35366	25747(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|expression expression|nmod|END_ENTITY	Increased peroxisomal fatty_acid beta-oxidation and enhanced expression of peroxisome_proliferator-activated_receptor-alpha in diabetic rat liver .
18475159	0	fatty_acid	22,32	peroxisome_proliferator-activated_receptor-gamma	72,120	fatty acid	peroxisome proliferator-activated receptor-gamma	CHEBI:35366	25664(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|pathway pathway|amod|END_ENTITY	Telmisartan increases fatty_acid oxidation in skeletal muscle through a peroxisome_proliferator-activated_receptor-gamma dependent pathway .
18653710	0	fatty_acid	69,79	peroxisome_proliferator-activated_receptor-gamma	11,59	fatty acid	peroxisome proliferator-activated receptor-gamma	CHEBI:35366	19016(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|augments augments|amod|END_ENTITY	Endogenous peroxisome_proliferator-activated_receptor-gamma augments fatty_acid uptake in oxidative muscle .
20920566	1	fatty_acid	129,139	peroxisome_proliferator-activated_receptor_a	38,82	fatty acid	peroxisome proliferator-activated receptor a	CHEBI:35366	5465	Chemical	Gene	metabolism|amod|START_ENTITY involved|nmod|metabolism genes|acl|involved expression|nmod|genes END_ENTITY|dobj|expression	activates peroxisome_proliferator-activated_receptor_a and regulates expression of genes involved in fatty_acid metabolism in human HepG2 cells .
24200804	0	fatty_acid	16,26	peroxisome_proliferator-activated_receptor_a	111,155	fatty acid	peroxisome proliferator-activated receptor a	CHEBI:35366	19013(Tax:10090)	Chemical	Gene	treated|nsubj|START_ENTITY treated|nmod|agonist agonist|amod|END_ENTITY	Long-chain free fatty_acid profiling analysis by liquid chromatography-mass spectrometry in mouse treated with peroxisome_proliferator-activated_receptor_a agonist .
24773203	0	fatty_acid	14,24	peroxisome_proliferator-activated_receptor_a	53,97	fatty acid	peroxisome proliferator-activated receptor a	CHEBI:35366	19013(Tax:10090)	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|nmod|END_ENTITY	Modulation of fatty_acid and bile_acid metabolism by peroxisome_proliferator-activated_receptor_a protects against alcoholic_liver_disease .
24858253	0	fatty_acid	48,58	peroxisome_proliferator-activated_receptor_a	91,135	fatty acid	peroxisome proliferator-activated receptor a	CHEBI:35366	19013(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|binding binding|nmod|END_ENTITY	A single amino_acid change humanizes long-chain fatty_acid binding and activation of mouse peroxisome_proliferator-activated_receptor_a .
10377439	0	fatty_acid	158,168	peroxisome_proliferator-activated_receptor_alpha	24,72	fatty acid	peroxisome proliferator-activated receptor alpha	CHEBI:35366	19013(Tax:10090)	Chemical	Gene	disorders|amod|START_ENTITY model|nmod|disorders mouse|nmod|model role|dep|mouse role|nmod|END_ENTITY	A critical role for the peroxisome_proliferator-activated_receptor_alpha -LRB- PPARalpha -RRB- in the cellular fasting response : the PPARalpha-null mouse as a model of fatty_acid oxidation disorders .
10669761	0	fatty_acid	154,164	peroxisome_proliferator-activated_receptor_alpha	38,86	fatty acid	peroxisome proliferator-activated receptor alpha	CHEBI:35366	5465	Chemical	Gene	enzymes|amod|START_ENTITY encoding|dobj|enzymes encoding|nsubj|END_ENTITY	The coactivator PGC-1 cooperates with peroxisome_proliferator-activated_receptor_alpha in transcriptional control of nuclear genes encoding mitochondrial fatty_acid oxidation enzymes .
10801788	0	fatty_acid	35,45	peroxisome_proliferator-activated_receptor_alpha	65,113	fatty acid	peroxisome proliferator-activated receptor alpha	CHEBI:35366	19013(Tax:10090)	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|nmod|END_ENTITY	Constitutive regulation of cardiac fatty_acid metabolism through peroxisome_proliferator-activated_receptor_alpha associated with age-dependent cardiac_toxicity .
11371554	0	fatty_acid	192,202	peroxisome_proliferator-activated_receptor_alpha	21,69	fatty acid	peroxisome proliferator-activated receptor alpha	CHEBI:35366	5465	Chemical	Gene	oxidation|amod|START_ENTITY modulation|nmod|oxidation mechanism|nmod|modulation pathway|dep|mechanism inhibits|dep|pathway inhibits|dobj|END_ENTITY	Hypoxia inhibits the peroxisome_proliferator-activated_receptor_alpha / retinoid_X_receptor gene regulatory pathway in cardiac myocytes : a mechanism for O2-dependent modulation of mitochondrial fatty_acid oxidation .
11734553	0	fatty_acid	127,137	peroxisome_proliferator-activated_receptor_alpha	11,59	fatty acid	peroxisome proliferator-activated receptor alpha	CHEBI:35366	19013(Tax:10090)	Chemical	Gene	rates|amod|START_ENTITY control|dep|rates role|nmod|control role|nmod|END_ENTITY	A role for peroxisome_proliferator-activated_receptor_alpha -LRB- PPARalpha -RRB- in the control of cardiac malonyl-CoA levels : reduced fatty_acid oxidation rates and increased glucose oxidation rates in the hearts of mice lacking PPARalpha are associated with higher concentrations of malonyl-CoA and reduced expression of malonyl-CoA_decarboxylase .
11867619	0	fatty_acid	43,53	peroxisome_proliferator-activated_receptor_alpha	118,166	fatty acid	peroxisome proliferator-activated receptor alpha	CHEBI:35366	5465	Chemical	Gene	START_ENTITY|nmod|ligands ligands|compound|END_ENTITY	Dual promoter structure of mouse and human fatty_acid translocase/CD36 genes and unique transcriptional activation by peroxisome_proliferator-activated_receptor_alpha and gamma ligands .
12853447	0	fatty_acid	12,22	peroxisome_proliferator-activated_receptor_alpha	37,85	fatty acid	peroxisome proliferator-activated receptor alpha	CHEBI:35366	25747(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|regulation regulation|nmod|activity activity|amod|END_ENTITY	Unsaturated fatty_acid regulation of peroxisome_proliferator-activated_receptor_alpha activity in rat primary hepatocytes .
15200495	0	fatty_acid	96,106	peroxisome_proliferator-activated_receptor_alpha	29,77	fatty acid	peroxisome proliferator-activated receptor alpha	CHEBI:35366	25747(Tax:10116)	Chemical	Gene	enzymes|amod|START_ENTITY expression|nmod|enzymes expression|nmod|END_ENTITY	Ligand-induced expression of peroxisome_proliferator-activated_receptor_alpha and activation of fatty_acid oxidation enzymes in fatty_liver .
15459119	0	fatty_acid	137,147	peroxisome_proliferator-activated_receptor_alpha	55,103	fatty acid	peroxisome proliferator-activated receptor alpha	CHEBI:35366	19013(Tax:10090)	Chemical	Gene	oxidation|amod|START_ENTITY up-regulation|nmod|oxidation up-regulation|amod|END_ENTITY	Pancreatic islet adaptation to fasting is dependent on peroxisome_proliferator-activated_receptor_alpha transcriptional up-regulation of fatty_acid oxidation .
15698396	0	fatty_acid	83,93	peroxisome_proliferator-activated_receptor_alpha	24,72	fatty acid	peroxisome proliferator-activated receptor alpha	CHEBI:35366	25747(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Decreased expression of peroxisome_proliferator-activated_receptor_alpha and liver fatty_acid binding protein after partial hepatectomy of rats and mice .
15699244	0	fatty_acid	145,155	peroxisome_proliferator-activated_receptor_alpha	4,52	fatty acid	peroxisome proliferator-activated receptor alpha	CHEBI:35366	5465	Chemical	Gene	proportions|amod|START_ENTITY altering|dobj|proportions intervention|acl|altering influences|nmod|intervention influences|nsubj|polymorphism polymorphism|amod|END_ENTITY	The peroxisome_proliferator-activated_receptor_alpha Leu162Val polymorphism influences the metabolic response to a dietary intervention altering fatty_acid proportions in healthy men .
25883783	0	fatty_acid	28,38	peroxisome_proliferator-activated_receptor_alpha	75,123	fatty acid	peroxisome proliferator-activated receptor alpha	CHEBI:35366	397239(Tax:9823)	Chemical	Gene	oxidation|amod|START_ENTITY oxidation|nmod|pigs pigs|nmod|agonist agonist|amod|END_ENTITY	Transplacental induction of fatty_acid oxidation in term fetal pigs by the peroxisome_proliferator-activated_receptor_alpha agonist clofibrate .
26031853	0	fatty_acid	86,96	peroxisome_proliferator-activated_receptor_alpha	8,56	fatty acid	peroxisome proliferator-activated receptor alpha	CHEBI:35366	374120(Tax:9031)	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of peroxisome_proliferator-activated_receptor_alpha in the expression of hepatic fatty_acid oxidation-related genes in chickens .
9094202	0	fatty_acid	154,164	peroxisome_proliferator-activated_receptor_alpha	64,112	fatty acid	peroxisome proliferator-activated receptor alpha	CHEBI:35366	25747(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|analogs analogs|nmod|END_ENTITY	Stereoselective effects of chiral clofibric_acid analogs on rat peroxisome_proliferator-activated_receptor_alpha -LRB- rPPAR_alpha -RRB- activation and peroxisomal fatty_acid beta-oxidation .
9341113	0	fatty_acid	50,60	peroxisome_proliferator-activated_receptor_alpha	111,159	fatty acid	peroxisome proliferator-activated receptor alpha	CHEBI:35366	19013(Tax:10090)	Chemical	Gene	synthase|amod|START_ENTITY suppression|nmod|synthase require|nsubj|suppression require|dobj|END_ENTITY	Polyunsaturated fatty_acid suppression of hepatic fatty_acid synthase and S14 gene expression does not require peroxisome_proliferator-activated_receptor_alpha .
9642225	0	fatty_acid	23,33	peroxisome_proliferator-activated_receptor_alpha	69,117	fatty acid	peroxisome proliferator-activated receptor alpha	CHEBI:35366	19013(Tax:10090)	Chemical	Gene	genes|amod|START_ENTITY Expression|nmod|genes regulated|nsubjpass|Expression regulated|nmod|activators activators|compound|END_ENTITY	Expression of putative fatty_acid transporter genes are regulated by peroxisome_proliferator-activated_receptor_alpha and gamma activators in a tissue - and inducer-specific manner .
11418499	0	fatty_acid	37,47	pheromone-binding_protein	97,122	fatty acid	pheromone-binding protein	CHEBI:35366	693050(Tax:7091)	Chemical	Gene	START_ENTITY|nmod|site site|nmod|END_ENTITY	Detection and removal of an artefact fatty_acid from the binding site of recombinant Bombyx_mori pheromone-binding_protein .
9873053	0	fatty_acid	59,69	phospholipase_D1	37,53	fatty acid	phospholipase D1	CHEBI:35366	5337	Chemical	Gene	Modification|nmod|START_ENTITY Modification|nmod|END_ENTITY	Modification of catalytically active phospholipase_D1 with fatty_acid in vivo .
4062899	0	fatty_acid	55,65	prolactin	30,39	fatty acid	prolactin	CHEBI:35366	100009394(Tax:9986)	Chemical	Gene	synthesis|amod|START_ENTITY stimulation|nmod|synthesis stimulation|compound|END_ENTITY	The effect of progesterone on prolactin stimulation of fatty_acid synthesis , glycerolipid synthesis and lipogenic-enzyme activities in mammary glands of pseudopregnant rabbits , after explant culture or intraductal injection .
16420480	0	fatty_acid	53,63	pyruvate_carboxylase	109,129	fatty acid	pyruvate carboxylase	CHEBI:35366	5091	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Prohibitin attenuates insulin-stimulated glucose and fatty_acid oxidation in adipose tissue by inhibition of pyruvate_carboxylase .
2762274	0	fatty_acid	10,20	secretin	24,32	fatty acid	secretin	CHEBI:35366	24769(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	Effect of fatty_acid on secretin release and cholinergic dependence of pancreatic secretion in rats .
607511	0	fatty_acid	55,65	somatostatin	14,26	fatty acid	somatostatin	CHEBI:35366	6750	Chemical	Gene	release|amod|START_ENTITY effect|nmod|release effect|nmod|END_ENTITY	The effect of somatostatin on epinephrine-induced free fatty_acid release in normal man .
2681189	0	fatty_acid	89,99	thioesterase	32,44	fatty acid	thioesterase	CHEBI:35366	396061(Tax:9031)	Chemical	Gene	START_ENTITY|nsubj|Characterization Characterization|nmod|END_ENTITY	Characterization of recombinant thioesterase and acyl carrier protein domains of chicken fatty_acid synthase expressed in Escherichia_coli .
2318831	0	fatty_acid	85,95	thioesterase_II	32,47	fatty acid	thioesterase II	CHEBI:35366	55301	Chemical	Gene	synthase|amod|START_ENTITY interaction|nmod|synthase participates|nmod|interaction participates|nsubj|region region|nmod|END_ENTITY	The carboxyl-terminal region of thioesterase_II participates in the interaction with fatty_acid synthase .
3805044	0	fatty_acid	54,64	thioesterase_II	33,48	fatty acid	thioesterase II	CHEBI:35366	64669(Tax:10116)	Chemical	Gene	synthetase|amod|START_ENTITY END_ENTITY|nmod|synthetase	Interaction of rat mammary gland thioesterase_II with fatty_acid synthetase is dependent on the presence of acyl chains on the synthetase .
7050281	0	fatty_acid	76,86	thioesterase_II	16,31	fatty acid	thioesterase II	CHEBI:35366	64669(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Localization Localization|nmod|END_ENTITY	Localization of thioesterase_II , the chain-length regulatory enzyme of milk fatty_acid synthesis , in rat mammary gland epithelial cells .
8446599	0	fatty_acid	135,145	thioesterase_II	52,67	fatty acid	thioesterase II	CHEBI:35366	64669(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY Roles|nmod|synthase Roles|nmod|catalysis catalysis|nmod|END_ENTITY	Roles of Ser101 , Asp236 , and His237 in catalysis of thioesterase_II and of the C-terminal region of the enzyme in its interaction with fatty_acid synthase .
476213	0	fatty_acid	49,59	thrombin	107,115	fatty acid	thrombin	CHEBI:35366	2147	Chemical	Gene	START_ENTITY|nmod|platelets platelets|acl|stimulated stimulated|nmod|END_ENTITY	Malonyldialdehyde formation , oxygen consumption , fatty_acid composition in newborn platelets stimulated by thrombin .
9177227	0	fatty_acid	59,69	uncoupling_protein-2	23,43	fatty acid	uncoupling protein-2	CHEBI:35366	54315(Tax:10116)	Chemical	Gene	oxidation|amod|START_ENTITY Induction|nmod|oxidation Induction|nmod|END_ENTITY	Induction by leptin of uncoupling_protein-2 and enzymes of fatty_acid oxidation .
20010438	0	fatty_acid	66,76	uncoupling_protein_2	12,32	fatty acid	uncoupling protein 2	CHEBI:35366	54315(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|role role|nmod|END_ENTITY	The role of uncoupling_protein_2 in the apoptosis induced by free fatty_acid in rat cardiomyocytes .
21063365	0	fatty_acid	73,83	vascular_endothelial_growth_factor	37,71	fatty acid	vascular endothelial growth factor	CHEBI:35366	7422	Chemical	Gene	START_ENTITY|nsubj|changes changes|appos|END_ENTITY	Electrophysiological changes , plasma vascular_endothelial_growth_factor , fatty_acid synthase , and adhesion molecules in diabetic_neuropathy .
10593920	0	fatty_acid	4,14	very_long_chain_acyl-CoA_synthetase	46,81	fatty acid	very long chain acyl-CoA synthetase	CHEBI:35366	11001	Chemical	Gene	protein|amod|START_ENTITY END_ENTITY|nsubj|protein	The fatty_acid transport protein -LRB- FATP1 -RRB- is a very_long_chain_acyl-CoA_synthetase .
20010914	0	fatty_acid_amide	68,84	FAAH	96,100	fatty acid amide	FAAH	null	2166	Chemical	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Association of polymorphisms of the cannabinoid_receptor -LRB- CNR1 -RRB- and fatty_acid_amide hydrolase -LRB- FAAH -RRB- genes with heroin_addiction : impact of long repeats of CNR1 .
20056290	0	fatty_acid_amide	68,84	FAAH	96,100	fatty acid amide	FAAH	null	2166	Chemical	Gene	hydrolase|compound|START_ENTITY hydrolase|appos|END_ENTITY	C358A missense polymorphism of the endocannabinoid degrading enzyme fatty_acid_amide hydrolase -LRB- FAAH -RRB- and insulin resistance in patients with diabetes_mellitus_type_2 .
21095576	1	fatty_acid_amide	137,153	FAAH	165,169	fatty acid amide	FAAH	null	29347(Tax:10116)	Chemical	Gene	hydrolase|compound|START_ENTITY hydrolase|appos|END_ENTITY	The enzyme fatty_acid_amide hydrolase -LRB- FAAH -RRB- catalyzes the in vivo degradation of the endocannabinoid anandamide , thus controlling its action at receptors .
23853040	0	fatty_acid_amide	63,79	FAAH	91,95	fatty acid amide	FAAH	null	2166	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	The macamide N-3-methoxybenzyl-linoleamide is a time-dependent fatty_acid_amide hydrolase -LRB- FAAH -RRB- inhibitor .
25788026	0	fatty_acid_amide	77,93	FAAH	105,109	fatty acid amide	FAAH	null	29347(Tax:10116)	Chemical	Gene	hydrolase|compound|START_ENTITY hydrolase|appos|END_ENTITY	Spinal neuronal cannabinoid receptors mediate urodynamic effects of systemic fatty_acid_amide hydrolase -LRB- FAAH -RRB- inhibition in rats .
27048155	0	fatty_acid_amide	33,49	FAAH	61,65	fatty acid amide	FAAH	null	29347(Tax:10116)	Chemical	Gene	hydrolase|compound|START_ENTITY hydrolase|appos|END_ENTITY	A comparison of novel , selective fatty_acid_amide hydrolase -LRB- FAAH -RRB- , monoacyglycerol lipase -LRB- MAGL -RRB- or dual FAAH/MAGL inhibitors to suppress acute and anticipatory nausea in rat models .
21899370	0	fatty_acid_amide	56,72	hFAAH	84,89	fatty acid amide	hFAAH	null	2166	Chemical	Gene	hydrolase|compound|START_ENTITY hydrolase|appos|END_ENTITY	SAR and LC/MS studies of b-lactamic inhibitors of human fatty_acid_amide hydrolase -LRB- hFAAH -RRB- : evidence of a nonhydrolytic process .
23287055	0	fatty_acid_amide	84,100	hFAAH	112,117	fatty acid amide	hFAAH	null	2166	Chemical	Gene	hydrolase|compound|START_ENTITY hydrolase|appos|END_ENTITY	An unprecedented reversible mode of action of b-lactams for the inhibition of human fatty_acid_amide hydrolase -LRB- hFAAH -RRB- .
24102523	0	fatty_acid_amide	90,106	hFAAH	118,123	fatty acid amide	hFAAH	null	2166	Chemical	Gene	hydrolase|compound|START_ENTITY hydrolase|appos|END_ENTITY	-LRB- S -RRB- -1 - -LRB- pent-4 ' - enoyl -RRB- -4 - -LRB- hydroxymethyl -RRB- - azetidin-2-one derivatives as inhibitors of human fatty_acid_amide hydrolase -LRB- hFAAH -RRB- : synthesis , biological evaluation and molecular modelling .
26071639	0	fatty_acid_amide	43,59	peroxisome_proliferator-activated_receptor	81,123	fatty acid amide	peroxisome proliferator-activated receptor	null	5465	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	Design and synthesis of silicon-containing fatty_acid_amide derivatives as novel peroxisome_proliferator-activated_receptor -LRB- PPAR -RRB- agonists .
9454375	0	fatty_acid_amides	12,29	phospholipase_A2	77,93	fatty acid amides	phospholipase A2	null	151056	Chemical	Gene	Effects|nmod|START_ENTITY catalyzed|nsubj|Effects catalyzed|nmod|END_ENTITY	-LSB- Effects of fatty_acid_amides on phosphatidylcholine hydrolysis catalyzed by phospholipase_A2 in micelles -RSB- .
21783371	0	fatty_acid_esters	50,67	gp120	11,16	fatty acid esters	gp120	CHEBI:35748	3700	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Synthesis , gp120 binding and anti-HIV activity of fatty_acid_esters of 1,1-linked _ disaccharides .
2995730	0	fatty_acids	82,93	17_beta-hydroxysteroid_dehydrogenase	24,60	fatty acids	17 beta-hydroxysteroid dehydrogenase	MESH:D005227	51478	Chemical	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of soluble 17_beta-hydroxysteroid_dehydrogenase of human placenta by fatty_acids .
12544904	0	fatty_acids	59,70	5-lipoxygenase	74,88	fatty acids	5-lipoxygenase	MESH:D005227	240	Chemical	Gene	START_ENTITY|nmod|apoptosis apoptosis|amod|END_ENTITY	Role of downstream metabolic processing of proinflammatory fatty_acids by 5-lipoxygenase in HL-60 cell apoptosis .
15305379	0	fatty_acids	91,102	5-lipoxygenase	145,159	fatty acids	5-lipoxygenase	MESH:D005227	240	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|role role|nmod|END_ENTITY	Activation of the orphan nuclear receptor RORalpha counteracts the proliferative effect of fatty_acids on prostate_cancer cells : crucial role of 5-lipoxygenase .
22748976	0	fatty_acids	34,45	5-lipoxygenase	86,100	fatty acids	5-lipoxygenase	MESH:D005227	240	Chemical	Gene	START_ENTITY|nmod|biosynthesis biosynthesis|nmod|metabolites metabolites|amod|END_ENTITY	The effect of low-dose marine n-3 fatty_acids on the biosynthesis of pro-inflammatory 5-lipoxygenase pathway metabolites in overweight subjects : a randomized controlled trial .
11294643	0	fatty_acids	89,100	ACAT1	27,32	fatty acids	ACAT1	MESH:D005227	38	Chemical	Gene	START_ENTITY|nsubj|modulation modulation|nmod|END_ENTITY	Differential modulation of ACAT1 and ACAT2 transcription and activity by long chain free fatty_acids in cultured cells .
19725980	0	fatty_acids	151,162	ACAT1	125,130	fatty acids	ACAT1	MESH:D005227	38	Chemical	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Modulation peroxisome proliferators activated receptor alpha -LRB- PPAR_alpha -RRB- and acyl_coenzyme_A : _ cholesterol_acyltransferase1 -LRB- ACAT1 -RRB- gene expression by fatty_acids in foam cell .
22678777	0	fatty_acids	69,80	ALOX15	29,35	fatty acids	ALOX15	MESH:D005227	246	Chemical	Gene	interaction|nmod|START_ENTITY END_ENTITY|dep|interaction	PTGS1 , PTGS2 , ALOX5 , ALOX12 , ALOX15 , and FLAP SNPs : interaction with fatty_acids in colon_cancer and rectal_cancer .
15533264	0	fatty_acids	111,122	ApoA-IV	12,19	fatty acids	ApoA-IV	MESH:D005227	397681(Tax:9823)	Chemical	Gene	Response|nmod|START_ENTITY Response|nmod|END_ENTITY	Response of ApoA-IV in pigs to long-term increased dietary oil intake and to the degree of unsaturation of the fatty_acids .
17339654	0	fatty_acids	30,41	Apolipoprotein_C-I	0,18	fatty acids	Apolipoprotein C-I	MESH:D005227	11812(Tax:10090)	Chemical	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Apolipoprotein_C-I binds free fatty_acids and reduces their intracellular esterification .
12524233	0	fatty_acids	43,54	C-reactive_protein	15,33	fatty acids	C-reactive protein	MESH:D005227	1401	Chemical	Gene	START_ENTITY|nsubj|serum serum|amod|END_ENTITY	Elevated serum C-reactive_protein and free fatty_acids among nondiabetic carriers of missense mutations in the gene encoding lamin_A / C -LRB- LMNA -RRB- with partial_lipodystrophy .
15100717	0	fatty_acids	14,25	C-reactive_protein	75,93	fatty acids	C-reactive protein	MESH:D005227	1401	Chemical	Gene	Intake|nmod|START_ENTITY lower|nsubj|Intake lower|dobj|concentrations concentrations|nmod|END_ENTITY	Intake of n-3 fatty_acids from fish does not lower serum concentrations of C-reactive_protein in healthy subjects .
17586424	0	fatty_acids	18,29	C-reactive_protein	33,51	fatty acids	C-reactive protein	MESH:D005227	1401	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|levels levels|amod|END_ENTITY	The effect of n-3 fatty_acids on C-reactive_protein levels in patients with chronic_renal_failure .
19454128	0	fatty_acids	21,32	C-reactive_protein	58,76	fatty acids	C-reactive protein	MESH:D005227	1401	Chemical	Gene	marker|amod|START_ENTITY marker|appos|END_ENTITY	Immune cell membrane fatty_acids and inflammatory marker , C-reactive_protein , in patients with multiple_sclerosis .
25087591	0	fatty_acids	37,48	C-reactive_protein	76,94	fatty acids	C-reactive protein	MESH:D005227	1401	Chemical	Gene	START_ENTITY|nmod|concentrations concentrations|nmod|END_ENTITY	Associations of erythrocyte membrane fatty_acids with the concentrations of C-reactive_protein , interleukin 1 receptor antagonist and adiponectin in 1373 men .
11478366	0	fatty_acids	65,76	CD36	8,12	fatty acids	CD36	MESH:D005227	12491(Tax:10090)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of CD36 in membrane transport and utilization of long-chain fatty_acids by different tissues .
11844979	0	fatty_acids	49,60	CD36	8,12	fatty acids	CD36	MESH:D005227	948	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of CD36 in membrane transport of long-chain fatty_acids .
18332148	0	fatty_acids	54,65	CD36	0,4	fatty acids	CD36	MESH:D005227	12491(Tax:10090)	Chemical	Gene	uptake|nmod|START_ENTITY mediates|dobj|uptake mediates|nsubj|END_ENTITY	CD36 mediates both cellular uptake of very long chain fatty_acids and their intestinal absorption in mice .
24040150	0	fatty_acids	60,71	CD36	23,27	fatty acids	CD36	MESH:D005227	29184(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY mediates|dobj|effect mediates|nsubj|END_ENTITY	Fatty_acid transporter CD36 mediates hypothalamic effect of fatty_acids on food intake in rats .
15990700	0	fatty_acids	45,56	COX-2	0,5	fatty acids	COX-2	MESH:D005227	4513	Chemical	Gene	inhibitors|nmod|START_ENTITY inhibitors|compound|END_ENTITY	COX-2 inhibitors and metabolism of essential fatty_acids .
16190133	0	fatty_acids	93,104	COX-2	4,9	fatty acids	COX-2	MESH:D005227	4513	Chemical	Gene	modified|nmod|START_ENTITY modified|nsubjpass|increase increase|compound|END_ENTITY	Can COX-2 inhibitor-induced increase in cardiovascular_disease risk be modified by essential fatty_acids ?
19755671	0	fatty_acids	52,63	COX-2	67,72	fatty acids	COX-2	MESH:D005227	5743	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Different impacts of saturated and unsaturated free fatty_acids on COX-2 expression in C -LRB- 2 -RRB- C -LRB- 12 -RRB- myotubes .
20593240	0	fatty_acids	35,46	COX-2	10,15	fatty acids	COX-2	MESH:D005227	4513	Chemical	Gene	affects|dobj|START_ENTITY affects|nsubj|inhibition inhibition|compound|END_ENTITY	Selective COX-2 inhibition affects fatty_acids , but not COX mRNA expression in patients with FAP .
20006574	0	fatty_acids	90,101	CREBH	40,45	fatty acids	CREBH	MESH:D005227	208677(Tax:10090)	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	The liver-enriched transcription factor CREBH is nutritionally regulated and activated by fatty_acids and PPARalpha .
15298768	0	fatty_acids	32,43	CYP2E1	65,71	fatty acids	CYP2E1	MESH:D005227	1571	Chemical	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Differential effects of dietary fatty_acids on the regulation of CYP2E1 and protein_kinase_C in human hepatoma HepG2 cells .
9354595	0	fatty_acids	59,70	CYP2E1	18,24	fatty acids	CYP2E1	MESH:D005227	25086(Tax:10116)	Chemical	Gene	hydroxylation|nmod|START_ENTITY Noninvolvement|dep|hydroxylation Noninvolvement|nmod|END_ENTITY	Noninvolvement of CYP2E1 in the -LRB- omega-1 -RRB- - hydroxylation of fatty_acids in rat kidney microsomes .
21948354	0	fatty_acids	36,47	Connexin_43	0,11	fatty acids	Connexin 43	MESH:D005227	2697	Chemical	Gene	effect|nmod|START_ENTITY effect|amod|END_ENTITY	Connexin_43 and metabolic effect of fatty_acids in stressed endothelial cells .
11421736	0	fatty_acids	61,72	Cox-2	0,5	fatty acids	Cox-2	MESH:D005227	5743	Chemical	Gene	effects|nmod|START_ENTITY effects|amod|END_ENTITY	Cox-2 inhibitory effects of naturally occurring and modified fatty_acids .
9367179	0	fatty_acids	25,36	DNA_polymerase_beta	40,59	fatty acids	DNA polymerase beta	MESH:D005227	5423	Chemical	Gene	action|nmod|START_ENTITY action|nmod|END_ENTITY	The inhibitory action of fatty_acids on DNA_polymerase_beta .
23497599	0	fatty_acids	41,52	FABP2	103,108	fatty acids	FABP2	MESH:D005227	2169	Chemical	Gene	START_ENTITY|nmod|genotypes genotypes|compound|END_ENTITY	Effects of EPA supplementation on plasma fatty_acids composition in hypertriglyceridemic subjects with FABP2 and PPARa genotypes .
25089883	0	fatty_acids	22,33	Ffar2	83,88	fatty acids	Ffar2	MESH:D005227	233079(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effect of short chain fatty_acids on the expression of free fatty_acid receptor 2 -LRB- Ffar2 -RRB- , Ffar3 and early-stage adipogenesis .
3917457	0	fatty_acids	19,30	GH	50,52	fatty acids	GH	MESH:D005227	2688	Chemical	Gene	START_ENTITY|nmod|growth_hormone growth_hormone|appos|END_ENTITY	The effect of free fatty_acids on growth_hormone -LRB- GH -RRB- - releasing hormone-mediated GH secretion in man .
3917457	0	fatty_acids	19,30	GH	81,83	fatty acids	GH	MESH:D005227	2688	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|secretion secretion|compound|END_ENTITY	The effect of free fatty_acids on growth_hormone -LRB- GH -RRB- - releasing hormone-mediated GH secretion in man .
9851776	0	fatty_acids	57,68	GH	88,90	fatty acids	GH	MESH:D005227	2688	Chemical	Gene	START_ENTITY|nmod|growth_hormone growth_hormone|appos|END_ENTITY	Effect of acute pharmacological reduction of plasma free fatty_acids on growth_hormone -LRB- GH -RRB- releasing hormone-induced GH secretion in obese adults with and without hypopituitarism .
21659478	2	fatty_acids	271,282	GHR	235,238	fatty acids	ES1	MESH:D005227	13884(Tax:10090)	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|compound|END_ENTITY	GHR expression is regulated by free fatty_acids -LRB- FFA -RRB- .
15774482	0	fatty_acids	5,16	GPR120	69,75	fatty acids	GPR120	MESH:D005227	107221(Tax:10090)	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|nmod|END_ENTITY	Free fatty_acids inhibit serum deprivation-induced apoptosis through GPR120 in a murine enteroendocrine cell line STC-1 .
12496284	0	fatty_acids	82,93	GPR40	38,43	fatty acids	GPR40	MESH:D005227	2864	Chemical	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty_acids .
1662535	0	fatty_acids	15,26	H,K-ATPase	45,55	fatty acids	H,K-ATPase	MESH:D005227	397552(Tax:9823)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of free fatty_acids and detergents on H,K-ATPase .
2510583	1	fatty_acids	26,37	H-ras	49,54	fatty acids	H-ras	MESH:D005227	293621(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of n-3 and n-6 fatty_acids on mammary H-ras expression and PGE2 levels in DMBA-treated rats .
11177189	0	fatty_acids	62,73	Insulin	0,7	fatty acids	Insulin	MESH:D005227	3630	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Insulin response and changes in composition of non-esterified fatty_acids in blood plasma of middle-aged men following isoenergetic fatty and carbohydrate breakfasts .
11921432	0	fatty_acids	47,58	Insulin	0,7	fatty acids	Insulin	MESH:D005227	3630	Chemical	Gene	role|nmod|START_ENTITY resistance|dep|role resistance|compound|END_ENTITY	Insulin resistance in type 2 diabetes : role of fatty_acids .
20028946	0	fatty_acids	103,114	Insulin	0,7	fatty acids	Insulin	MESH:D005227	3630	Chemical	Gene	suppressing|dobj|START_ENTITY inhibits|advcl|suppressing inhibits|nsubj|END_ENTITY	Insulin acutely inhibits intestinal lipoprotein secretion in humans in part by suppressing plasma free fatty_acids .
20409874	0	fatty_acids	33,44	Insulin	0,7	fatty acids	Insulin	MESH:D005227	3630	Chemical	Gene	actions|nmod|START_ENTITY actions|nmod:poss|END_ENTITY	Insulin 's actions on plasma free fatty_acids are normal in patients with stage 2 to 3 chronic_kidney_disease .
25436738	0	fatty_acids	88,99	Insulin	0,7	fatty acids	Insulin	MESH:D005227	3630	Chemical	Gene	resistance|nmod|START_ENTITY resistance|compound|END_ENTITY	Insulin resistance : cross-talk between adipose tissue and skeletal muscle , through free fatty_acids , liver X receptor , and peroxisome proliferator-activated receptor-a signaling .
10416955	0	fatty_acids	169,180	Interleukin-6	0,13	fatty acids	Interleukin-6	MESH:D005227	3569	Chemical	Gene	down-regulation|nmod|START_ENTITY END_ENTITY|dep|down-regulation	Interleukin-6 as a central mediator of cardiovascular risk associated with chronic_inflammation , smoking , diabetes , and visceral obesity : down-regulation with essential fatty_acids , ethanol and pentoxifylline .
11171094	0	fatty_acids	11,22	L-CPT_I	77,84	fatty acids	L-CPT I	MESH:D005227	12894(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|expression expression|appos|END_ENTITY	Long-chain fatty_acids regulate liver_carnitine_palmitoyltransferase_I gene -LRB- L-CPT_I -RRB- expression through a peroxisome-proliferator-activated_receptor_alpha -LRB- PPARalpha -RRB- - independent pathway .
16262600	3	fatty_acids	707,718	L-FABP	657,663	fatty acids	L-FABP	MESH:D005227	14080(Tax:10090)	Chemical	Gene	oxidation|nmod|START_ENTITY indicated|nmod|oxidation indicated|dobj|involvement involvement|nmod|END_ENTITY	More recent observations , notably on L-FABP-deficient mice , indicated a possible direct involvement of L-FABP in the peroxisomal oxidation of long-chain fatty_acids .
24628888	0	fatty_acids	41,52	L-FABP	98,104	fatty acids	L-FABP	MESH:D005227	2168	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Structural and functional interaction of fatty_acids with human liver fatty_acid-binding protein -LRB- L-FABP -RRB- T94A variant .
24140860	0	fatty_acids	60,71	LL-37	46,51	fatty acids	LL-37	MESH:D005227	820	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of human cathelicidin LL-37 by free fatty_acids and their analogs .
22110480	0	fatty_acids	44,55	LYRM1	14,19	fatty acids	LYRM1	MESH:D005227	57149	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Regulation of LYRM1 gene expression by free fatty_acids , adipokines , and rosiglitazone in 3T3-L1 adipocytes .
12475384	0	fatty_acids	28,39	Leptin	0,6	fatty acids	Leptin	MESH:D005227	25608(Tax:10116)	Chemical	Gene	fate|nmod|START_ENTITY controls|dobj|fate controls|nsubj|END_ENTITY	Leptin controls the fate of fatty_acids in isolated rat white adipocytes .
2495333	0	fatty_acids	37,48	Lipoprotein_lipase	0,18	fatty acids	Lipoprotein lipase	MESH:D005227	24539(Tax:10116)	Chemical	Gene	source|nmod|START_ENTITY END_ENTITY|dep|source	Lipoprotein_lipase : a source of free fatty_acids in bronchoalveolar lining fluid .
19030909	0	fatty_acids	25,36	Lp-PLA2	84,91	fatty acids	Lp-PLA2	MESH:D005227	7941	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of marine n-3 fatty_acids in different doses on plasma concentrations of Lp-PLA2 in healthy adults .
21291763	0	fatty_acids	70,81	MK-0354	46,53	fatty acids	MK-0354	MESH:D005227	1477657(Tax:190192)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of a niacin receptor partial agonist , MK-0354 , on plasma free fatty_acids , lipids , and cutaneous flushing in humans .
19228118	0	fatty_acids	66,77	MUC2	35,39	fatty acids	MUC2	MESH:D005227	4583	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	The regulation of intestinal mucin MUC2 expression by short-chain fatty_acids : implications for epithelial protection .
22841543	0	fatty_acids	23,34	NF-kB	89,94	fatty acids	NF-kB	MESH:D005227	81736(Tax:10116)	Chemical	Gene	therapy|nmod|START_ENTITY END_ENTITY|nsubj|therapy	Adjunct therapy of n-3 fatty_acids to 5-ASA ameliorates inflammatory score and decreases NF-kB in rats with TNBS-induced colitis .
17161819	0	fatty_acids	41,52	NF-kappaB	127,136	fatty acids	NF-kappaB	MESH:D005227	18033(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|involvement involvement|nmod|END_ENTITY	Anti-inflammatory effects of short chain fatty_acids in IFN-gamma-stimulated RAW 264.7 murine macrophage cells : involvement of NF-kappaB and ERK signaling pathways .
15733855	0	fatty_acids	5,16	PGC-1alpha	26,36	fatty acids	PGC-1alpha	MESH:D005227	83516(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|expression expression|compound|END_ENTITY	Free fatty_acids increase PGC-1alpha expression in isolated rat islets .
18202540	0	fatty_acids	106,117	PPARalpha	140,149	fatty acids	PPARalpha	MESH:D005227	25747(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Possible role of fatty_acids in milk as the regulator of the expression of cytosolic binding proteins for fatty_acids and vitamin_A through PPARalpha in developing rats .
18202540	0	fatty_acids	17,28	PPARalpha	140,149	fatty acids	PPARalpha	MESH:D005227	25747(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Possible role of fatty_acids in milk as the regulator of the expression of cytosolic binding proteins for fatty_acids and vitamin_A through PPARalpha in developing rats .
6621364	0	fatty_acids	47,58	Pancreatic_polypeptide	0,22	fatty acids	Pancreatic polypeptide	MESH:D005227	490944(Tax:9615)	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|END_ENTITY	Pancreatic_polypeptide release by intraluminal fatty_acids .
17936861	0	fatty_acids	85,96	Peptide_YY	0,10	fatty acids	Peptide YY	MESH:D005227	5697	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|levels levels|amod|END_ENTITY	Peptide_YY levels are associated with appetite suppression in response to long-chain fatty_acids .
3770364	0	fatty_acids	22,33	Peptide_YY	0,10	fatty acids	Peptide YY	MESH:D005227	607156(Tax:9615)	Chemical	Gene	release|nmod|START_ENTITY release|amod|END_ENTITY	Peptide_YY release by fatty_acids is sufficient to inhibit gastric emptying in dogs .
10926831	0	fatty_acids	84,95	Peroxisome-proliferator-activated_receptor_delta	0,48	fatty acids	Peroxisome-proliferator-activated receptor delta	MESH:D005227	5467	Chemical	Gene	effects|nmod|START_ENTITY mediates|dobj|effects mediates|nsubj|END_ENTITY	Peroxisome-proliferator-activated_receptor_delta mediates the effects of long-chain fatty_acids on post-confluent cell proliferation .
7913466	0	fatty_acids	131,142	Peroxisome_proliferator-activated_receptor	0,42	fatty acids	Peroxisome proliferator-activated receptor	MESH:D005227	25747(Tax:10116)	Chemical	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Peroxisome_proliferator-activated_receptor mediates induction of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by fatty_acids .
3836246	0	fatty_acids	38,49	Phospholipase_A2	0,16	fatty acids	Phospholipase A2	MESH:D005227	151056	Chemical	Gene	release|nmod|START_ENTITY release|amod|END_ENTITY	Phospholipase_A2 dependent release of fatty_acids from peroxidized membranes .
3949754	1	fatty_acids	153,164	SBP	281,284	fatty acids	SBP	MESH:D005227	8991	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of unsaturated and saturated nonesterified fatty_acids -LRB- NEFAs -RRB- on the electrophoretic , immunological , and steroid-binding properties of human sex_hormone-binding_protein -LRB- SBP -RRB- were investigated .
20352619	0	fatty_acids	37,48	STC-1	121,126	fatty acids	STC-1	MESH:D005227	6781	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Acute and chronic effects of dietary fatty_acids on cholecystokinin expression , storage and secretion in enteroendocrine STC-1 cells .
23766515	0	fatty_acids	102,113	Sphingosine_kinase_1	0,20	fatty acids	Sphingosine kinase 1	MESH:D005227	20698(Tax:10090)	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Sphingosine_kinase_1 is regulated by peroxisome_proliferator-activated_receptor a in response to free fatty_acids and is essential for skeletal muscle interleukin-6 production and signaling in diet-induced obesity .
6682930	0	fatty_acids	47,58	Spin	0,4	fatty acids	Spin	MESH:D005227	361217(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|END_ENTITY	Spin labelling studies of cytolysis induced by fatty_acids .
20809180	0	fatty_acids	40,51	TNF-a	61,66	fatty acids	TNF-a	MESH:D005227	21926(Tax:10090)	Chemical	Gene	modulate|nsubj|START_ENTITY modulate|dobj|expression expression|amod|END_ENTITY	Molecular mechanisms by which saturated fatty_acids modulate TNF-a expression in mouse macrophage lineage .
24104695	0	fatty_acids	10,21	UDP-glucuronosyltransferase_1A1	31,62	fatty acids	UDP-glucuronosyltransferase 1A1	MESH:D005227	54658	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Impact of fatty_acids on human UDP-glucuronosyltransferase_1A1 activity and its expression in neonatal hyperbilirubinemia .
1438299	0	fatty_acids	62,73	aP2	13,16	fatty acids	aP2	MESH:D005227	2167	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|expression expression|amod|END_ENTITY	Induction of aP2 gene expression by nonmetabolized long-chain fatty_acids .
1753216	2	fatty_acids	89,100	aP2	77,80	fatty acids	aP2	MESH:D005227	21418(Tax:10090)	Chemical	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Kinetics of induction of the aP2 gene by fatty_acids and modulation by dexamethasone .
156609	0	fatty_acids	23,34	adenosinetriphosphatase	36,59	fatty acids	adenosinetriphosphatase	MESH:D005227	481	Chemical	Gene	study|nmod|START_ENTITY END_ENTITY|nsubj|study	A study of erythrocyte fatty_acids , adenosinetriphosphatase and acetylcholinesterase in cystic fibrosis .
15164330	0	fatty_acids	40,51	adiponectin	20,31	fatty acids	adiponectin	MESH:D005227	9370	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Acute regulation of adiponectin by free fatty_acids .
18239552	0	fatty_acids	51,62	adiponectin	74,85	fatty acids	adiponectin	MESH:D005227	9370	Chemical	Gene	START_ENTITY|advcl|fasting fasting|dobj|END_ENTITY	No evidence of an effect of alterations in dietary fatty_acids on fasting adiponectin over 3 weeks .
20237168	0	fatty_acids	7,18	adiponectin	75,86	fatty acids	adiponectin	MESH:D005227	9370	Chemical	Gene	associated|nsubjpass|START_ENTITY associated|advcl|circulating circulating|dobj|END_ENTITY	Plasma fatty_acids and desaturase activity are associated with circulating adiponectin in healthy adolescent girls .
21725859	0	fatty_acids	81,92	adipose_triglyceride_lipase	23,50	fatty acids	adipose triglyceride lipase	MESH:D005227	431066(Tax:9031)	Chemical	Gene	up-regulation|nmod|START_ENTITY up-regulation|nmod|END_ENTITY	Acute up-regulation of adipose_triglyceride_lipase and release of non-esterified fatty_acids by dexamethasone in chicken adipose tissue .
24316317	0	fatty_acids	17,28	albumin	61,68	fatty acids	albumin	MESH:D005227	213	Chemical	Gene	influence|nmod|START_ENTITY END_ENTITY|nsubj|influence	The influence of fatty_acids on determination of human serum albumin thiol group .
659515	0	fatty_acids	8,19	albumin	56,63	fatty acids	albumin	MESH:D005227	213	Chemical	Gene	Role|nmod|START_ENTITY END_ENTITY|nsubj|Role	Role of fatty_acids in growth-promoting effect of serum albumin on hamster cells in vitro .
19428350	0	fatty_acids	13,24	alcohol_dehydrogenase_3	113,136	fatty acids	alcohol dehydrogenase 3	MESH:D005227	126	Chemical	Gene	mediated|nsubj|START_ENTITY mediated|nmod|END_ENTITY	Medium-chain fatty_acids and glutathione derivatives as inhibitors of S-nitrosoglutathione reduction mediated by alcohol_dehydrogenase_3 .
1379224	1	fatty_acids	211,222	alpha-Fetoprotein	129,146	fatty acids	alpha-fetoprotein	MESH:D005227	100999799	Chemical	Gene	reversibly|dobj|START_ENTITY reversibly|nsubj|END_ENTITY	alpha-Fetoprotein and albumin , two members of a multigene family , reversibly bind fatty_acids with high affinity .
15522828	0	fatty_acids	32,43	alpha-amino-beta-carboxymuconate-epsilon-semialdehyde_decarboxylase	57,124	fatty acids	alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase	MESH:D005227	171385(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nsubj|effects	Differential effects of dietary fatty_acids on rat liver alpha-amino-beta-carboxymuconate-epsilon-semialdehyde_decarboxylase activity and gene expression .
1373954	0	fatty_acids	38,49	alpha-fetoprotein	86,103	fatty acids	alpha-fetoprotein	MESH:D005227	24177(Tax:10116)	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|properties properties|nmod|END_ENTITY	In vivo transient rise in plasma free fatty_acids alters the functional properties of alpha-fetoprotein .
2472294	0	fatty_acids	80,91	alpha-fetoprotein	19,36	fatty acids	alpha-fetoprotein	MESH:D005227	24177(Tax:10116)	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of rat alpha-fetoprotein and albumin with polyunsaturated and other fatty_acids : determination of apparent association constants .
2475177	0	fatty_acids	75,86	alpha-fetoprotein	43,60	fatty acids	alpha-fetoprotein	MESH:D005227	174	Chemical	Gene	influence|nmod|START_ENTITY changes|dep|influence changes|nmod|END_ENTITY	Conformational changes in rodent and human alpha-fetoprotein : influence of fatty_acids .
6185269	0	fatty_acids	11,22	alpha-fetoprotein	32,49	fatty acids	alpha-fetoprotein	MESH:D005227	397586(Tax:9823)	Chemical	Gene	bound|nsubj|START_ENTITY bound|nmod|END_ENTITY	Long-chain fatty_acids bound to alpha-fetoprotein and to serum albumin from fetal and adult pig .
75886	0	fatty_acids	16,27	alpha-fetoprotein	37,54	fatty acids	alpha-fetoprotein	MESH:D005227	174	Chemical	Gene	presence|nmod|START_ENTITY presence|nmod|END_ENTITY	The presence of fatty_acids in human alpha-fetoprotein .
83161	0	fatty_acids	11,22	alpha-fetoprotein	41,58	fatty acids	alpha-fetoprotein	MESH:D005227	397586(Tax:9823)	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of fatty_acids and tryptophan to alpha-fetoprotein from fetal pigs .
10471121	0	fatty_acids	52,63	alpha-foetoprotein	14,32	fatty acids	alpha-foetoprotein	MESH:D005227	24177(Tax:10116)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of alpha-foetoprotein gene expression by fatty_acids and fibrates .
3260860	0	fatty_acids	21,32	androgen_receptor	51,68	fatty acids	androgen receptor	MESH:D005227	24208(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|the the|nmod|END_ENTITY	Inhibitory effect of fatty_acids on the binding of androgen_receptor and R1881 .
9078267	0	fatty_acids	14,25	angiotensinogen	29,44	fatty acids	angiotensinogen	MESH:D005227	183	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Regulation by fatty_acids of angiotensinogen gene expression in preadipose cells .
12181317	0	fatty_acids	102,113	calcium-independent_phospholipase_A2	15,51	fatty acids	calcium-independent phospholipase A2	MESH:D005227	57104	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of calcium-independent_phospholipase_A2 in hydrogen_peroxide-induced accumulation of free fatty_acids in human U937 cells .
20352619	0	fatty_acids	37,48	cholecystokinin	52,67	fatty acids	cholecystokinin	MESH:D005227	885	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Acute and chronic effects of dietary fatty_acids on cholecystokinin expression , storage and secretion in enteroendocrine STC-1 cells .
22313587	0	fatty_acids	31,42	cholecystokinin	46,61	fatty acids	cholecystokinin	MESH:D005227	885	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	Effect of different long-chain fatty_acids on cholecystokinin release in vitro and energy intake in free-living healthy males .
20166680	0	fatty_acids	102,113	cholesterol_esterase	127,147	fatty acids	cholesterol esterase	MESH:D005227	1056	Chemical	Gene	START_ENTITY|acl|generated generated|nmod|END_ENTITY	Complement protein C1q recognizes enzymatically modified low-density lipoprotein through unesterified fatty_acids generated by cholesterol_esterase .
6424574	0	fatty_acids	45,56	chymase	14,21	fatty acids	chymase	MESH:D005227	1215	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activity activity|amod|END_ENTITY	Inhibition of chymase activity by long chain fatty_acids .
8319565	0	fatty_acids	126,137	corticosteroid-binding_globulin	51,82	fatty acids	corticosteroid-binding globulin	MESH:D005227	299270(Tax:10116)	Chemical	Gene	Stimulation|nmod|START_ENTITY Stimulation|nmod|END_ENTITY	Stimulation of the binding properties of adult rat corticosteroid-binding_globulin by a lipolysis-induced rise in plasma free fatty_acids .
2546826	0	fatty_acids	28,39	cytochrome-c_oxidase	80,100	fatty acids	cytochrome-c oxidase	MESH:D005227	282199(Tax:9913)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of non-esterified fatty_acids on respiratory control of reconstituted cytochrome-c_oxidase .
410449	0	fatty_acids	82,93	cytochrome_b5	30,43	fatty acids	cytochrome b5	MESH:D005227	64001(Tax:10116)	Chemical	Gene	Evidence|nmod|START_ENTITY Evidence|nmod|END_ENTITY	Evidence for participation of cytochrome_b5 in microsomal delta-6 desaturation of fatty_acids .
6418998	0	fatty_acids	18,29	delta_5_desaturase	33,51	fatty acids	delta 5 desaturase	MESH:D005227	84575(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	Effect of dietary fatty_acids on delta_5_desaturase activity and biosynthesis of arachidonic_acid in rat liver microsomes .
7753283	0	fatty_acids	29,40	erythropoietin	6,20	fatty acids	erythropoietin	MESH:D005227	2056	Chemical	Gene	START_ENTITY|nsubj|changes changes|compound|END_ENTITY	Human erythropoietin changes fatty_acids composition of blood platelet phospholipids in hemodialyzed patients .
12522466	11	fatty_acids	1941,1952	glucose	1956,1963	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	circulating|dobj|START_ENTITY circulating|nmod|END_ENTITY	At the same time , the response of circulating fatty_acids to glucose is retarded during pregnancy .
10484127	0	fatty_acids	40,51	growth_hormone	79,93	fatty acids	growth hormone	MESH:D005227	443329(Tax:9940)	Chemical	Gene	infusion|nmod|START_ENTITY Effects|nmod|infusion Effects|nmod|END_ENTITY	Effects of ruminal infusion of volatile fatty_acids on plasma concentration of growth_hormone and insulin in sheep .
10484133	0	fatty_acids	35,46	growth_hormone	50,64	fatty acids	growth hormone	MESH:D005227	102171600	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Suppressing effects of short-chain fatty_acids on growth_hormone -LRB- GH -RRB- - releasing hormone-induced GH release in isolated anterior pituitary cells of goats .
10843791	0	fatty_acids	12,23	growth_hormone	59,73	fatty acids	growth hormone	MESH:D005227	102171600	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|release release|nmod|END_ENTITY	Short-chain fatty_acids inhibit the release and content of growth_hormone in anterior pituitary cells of the goat .
11134132	0	fatty_acids	18,29	growth_hormone	55,69	fatty acids	growth hormone	MESH:D005227	2688	Chemical	Gene	Reduction|nmod|START_ENTITY enhances|nsubj|Reduction enhances|dobj|responses responses|compound|END_ENTITY	Reduction of free fatty_acids by acipimox enhances the growth_hormone -LRB- GH -RRB- responses to GH-releasing peptide 2 in elderly men .
1166895	0	fatty_acids	31,42	growth_hormone	10,24	fatty acids	growth hormone	MESH:D005227	2688	Chemical	Gene	START_ENTITY|nsubj|Cortisol Cortisol|appos|END_ENTITY	Cortisol , growth_hormone , free fatty_acids , and experimentally evoked affective arousal .
12970312	0	fatty_acids	26,37	growth_hormone	105,119	fatty acids	growth hormone	MESH:D005227	2688	Chemical	Gene	role|nmod|START_ENTITY role|acl|fasting fasting|nmod|END_ENTITY	The decisive role of free fatty_acids for protein conservation during fasting in humans with and without growth_hormone .
14559725	0	fatty_acids	47,58	growth_hormone	24,38	fatty acids	growth hormone	MESH:D005227	2688	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Metabolic regulation of growth_hormone by free fatty_acids , somatostatin , and ghrelin in HIV-lipodystrophy .
15189427	0	fatty_acids	33,44	growth_hormone	130,144	fatty acids	growth hormone	MESH:D005227	102406287	Chemical	Gene	Changes|nmod|START_ENTITY END_ENTITY|nsubj|Changes	Changes in plasma non-esterified fatty_acids , glucose and alpha-amino_nitrogen and their relationship with body weight and plasma growth_hormone in growing buffaloes -LRB- Bubalus_bubalis -RRB- .
1612014	0	fatty_acids	71,82	growth_hormone	14,28	fatty acids	growth hormone	MESH:D005227	443329(Tax:9940)	Chemical	Gene	derived|dobj|START_ENTITY derived|nsubj|Modulation Modulation|nmod|secretion secretion|amod|END_ENTITY	Modulation of growth_hormone secretion by thermogenically derived free fatty_acids in the perinatal lamb .
1673023	0	fatty_acids	51,62	growth_hormone	74,88	fatty acids	growth hormone	MESH:D005227	81668(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|responses responses|compound|END_ENTITY	Evidence for a direct pituitary inhibition by free fatty_acids of in vivo growth_hormone responses to growth_hormone-releasing hormone in the rat .
17341555	0	fatty_acids	30,41	growth_hormone	106,120	fatty acids	growth hormone	MESH:D005227	2688	Chemical	Gene	effects|nmod|START_ENTITY metabolism|nsubj|effects metabolism|nmod|blockade blockade|nmod|END_ENTITY	Dose-response effects of free fatty_acids on glucose and lipid metabolism during somatostatin blockade of growth_hormone and insulin in humans .
17492951	0	fatty_acids	16,27	growth_hormone	29,43	fatty acids	growth hormone	MESH:D005227	2688	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of free fatty_acids , growth_hormone and growth_hormone_receptor blockade on serum ghrelin levels in humans .
19276230	0	fatty_acids	5,16	growth_hormone	25,39	fatty acids	growth hormone	MESH:D005227	2688	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|ccomp|signal signal|nsubj|/ /|amod|END_ENTITY	Free fatty_acids inhibit growth_hormone / signal transducer and activator of transcription-5 signaling in human muscle : a potential feedback mechanism .
2198432	0	fatty_acids	120,131	growth_hormone	4,18	fatty acids	growth hormone	MESH:D005227	2688	Chemical	Gene	occurs|nmod|START_ENTITY technique|dep|occurs technique|amod|END_ENTITY	The growth_hormone clamp technique : inhibition of growth_hormone release by growth_hormone occurs independently of free fatty_acids .
2198432	0	fatty_acids	120,131	growth_hormone	50,64	fatty acids	growth hormone	MESH:D005227	2688	Chemical	Gene	occurs|nmod|START_ENTITY occurs|nsubj|inhibition inhibition|nmod|release release|amod|END_ENTITY	The growth_hormone clamp technique : inhibition of growth_hormone release by growth_hormone occurs independently of free fatty_acids .
2198432	0	fatty_acids	120,131	growth_hormone	76,90	fatty acids	growth hormone	MESH:D005227	2688	Chemical	Gene	occurs|nmod|START_ENTITY occurs|nsubj|inhibition inhibition|nmod|release release|nmod|END_ENTITY	The growth_hormone clamp technique : inhibition of growth_hormone release by growth_hormone occurs independently of free fatty_acids .
2502553	0	fatty_acids	78,89	growth_hormone	29,43	fatty acids	growth hormone	MESH:D005227	2688	Chemical	Gene	rises|nmod|START_ENTITY END_ENTITY|dep|rises	Intravenous refeeding blocks growth_hormone -LRB- GH -RRB- - provoked rises in serum free fatty_acids and blunting of somatotroph response to GH-releasing hormone in normal men .
2544416	0	fatty_acids	5,16	growth_hormone	26,40	fatty acids	growth hormone	MESH:D005227	443329(Tax:9940)	Chemical	Gene	suppress|nsubj|START_ENTITY suppress|xcomp|END_ENTITY	Free fatty_acids suppress growth_hormone , but not luteinizing hormone , secretion in sheep .
3882538	0	fatty_acids	142,153	growth_hormone	67,81	fatty acids	growth hormone	MESH:D005227	100356068(Tax:9986)	Chemical	Gene	levels|nmod|START_ENTITY END_ENTITY|nmod|levels	Different acute in vivo effects of bacterial derived and pituitary growth_hormone preparations on plasma levels of glucagon , insulin and free fatty_acids in rabbits .
564386	0	fatty_acids	202,213	growth_hormone	11,25	fatty acids	growth hormone	MESH:D005227	102171600	Chemical	Gene	Release|appos|START_ENTITY Release|nmod|END_ENTITY	Release of growth_hormone in lactating and non-lactating goats in relation to behaviour , stages of sleep , electroencephalograms , environmental stimuli and levels of prolactin , insulin , glucose and free fatty_acids in the circulation .
8121306	0	fatty_acids	20,31	growth_hormone	48,62	fatty acids	growth hormone	MESH:D005227	2688	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|secretion secretion|amod|END_ENTITY	Interaction of free fatty_acids and arginine on growth_hormone secretion in man .
8923850	0	fatty_acids	148,159	growth_hormone	15,29	fatty acids	growth hormone	MESH:D005227	2688	Chemical	Gene	reduction|nmod|START_ENTITY Restoration|nmod|reduction Restoration|nmod|response response|amod|END_ENTITY	Restoration of growth_hormone -LRB- GH -RRB- response to GH-releasing hormone in elderly and obese subjects by acute pharmacological reduction of plasma free fatty_acids .
9284763	0	fatty_acids	47,58	growth_hormone	72,86	fatty acids	growth hormone	MESH:D005227	2688	Chemical	Gene	reduction|nmod|START_ENTITY enhances|nsubj|reduction enhances|dep|releasing releasing|nsubj|END_ENTITY	Acute pharmacological reduction of plasma free fatty_acids enhances the growth_hormone -LRB- GH -RRB- - releasing hormone-mediated GH secretion in patients with Cushing 's _ syndrome .
16825291	0	fatty_acids	67,78	growth_hormone_receptor	14,37	fatty acids	growth hormone receptor	MESH:D005227	2690	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Inhibition of growth_hormone_receptor gene expression by saturated fatty_acids : role of Kruppel-like zinc finger factor , ZBP-89 .
1542440	0	fatty_acids	27,38	growth_hormone_releasing_hormone	42,74	fatty acids	growth hormone releasing hormone	MESH:D005227	29446(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	Stimulatory effect of free fatty_acids on growth_hormone_releasing_hormone secretion by fetal rat neurons in monolayer culture .
19856197	0	fatty_acids	21,32	haptoglobin	42,53	fatty acids	haptoglobin	MESH:D005227	15439(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Long chain saturated fatty_acids increase haptoglobin gene expression in C57BL/6J mice adipose tissue and 3T3-L1 cells .
10078559	0	fatty_acids	11,22	insulin	50,57	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of fatty_acids and ketone bodies on basal insulin secretion in type 2 diabetes .
10354364	0	fatty_acids	5,16	insulin	18,25	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	START_ENTITY|appos|resistance resistance|compound|END_ENTITY	Free fatty_acids , insulin resistance , and type_2_diabetes_mellitus .
10480616	0	fatty_acids	27,38	insulin	62,69	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	lowering|nmod|START_ENTITY improves|nsubj|lowering improves|dobj|resistance resistance|compound|END_ENTITY	Overnight lowering of free fatty_acids with Acipimox improves insulin resistance and glucose_tolerance in obese diabetic and nondiabetic subjects .
10544188	0	fatty_acids	31,42	insulin	81,88	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	utilize|dobj|START_ENTITY Markers|acl|utilize Markers|dep|relation relation|nmod|resistance resistance|compound|END_ENTITY	Markers of capacity to utilize fatty_acids in human skeletal muscle : relation to insulin resistance and obesity and effects of weight_loss .
10778867	0	fatty_acids	20,31	insulin	109,116	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	Elevation|nmod|START_ENTITY has|nsubj|Elevation has|dobj|effect effect|nmod|secretion secretion|compound|END_ENTITY	Elevation of plasma fatty_acids by ten-hour intralipid infusion has no effect on basal or glucose-stimulated insulin secretion in normal man .
11172480	0	fatty_acids	73,84	insulin	99,106	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	phospholipid|dobj|START_ENTITY phospholipid|nmod|markers markers|nmod|resistance resistance|compound|END_ENTITY	Relationship of dietary fat and serum cholesterol_ester and phospholipid fatty_acids to markers of insulin resistance in men and women with a range of glucose tolerance .
11227245	0	fatty_acids	13,24	insulin	44,51	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	START_ENTITY|nmod|etiology etiology|nmod|resistance resistance|compound|END_ENTITY	-LSB- Obesity and fatty_acids in the etiology of insulin resistance -RSB- .
112697	0	fatty_acids	62,73	insulin	29,36	fatty acids	insulin	MESH:D005227	105613195	Chemical	Gene	-LSB-|nmod|START_ENTITY -LSB-|dobj|influence influence|nmod|END_ENTITY	-LSB- The influence of endogenous insulin and glucagon on the free fatty_acids in the circulating blood plasma -RSB- .
11826668	0	fatty_acids	6,17	insulin	32,39	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	START_ENTITY|dep|mediators mediators|nmod|resistance resistance|compound|END_ENTITY	-LSB- Free fatty_acids : mediators of insulin resistance and atherosclerosis -RSB- .
12120417	0	fatty_acids	16,27	insulin	31,38	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of free fatty_acids on insulin secretion in obesity .
12476925	0	fatty_acids	53,64	insulin	32,39	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|responses responses|compound|END_ENTITY	Effects of long-term fasting on insulin responses to fatty_acids in man .
12629551	0	fatty_acids	5,16	insulin	26,33	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	START_ENTITY|xcomp|regulate regulate|dobj|secretion secretion|compound|END_ENTITY	Free fatty_acids regulate insulin secretion from pancreatic beta cells through GPR40 .
12673957	0	fatty_acids	42,53	insulin	6,13	fatty acids	insulin	MESH:D005227	280829(Tax:9913)	Chemical	Gene	esterified|dobj|START_ENTITY esterified|nsubj|END_ENTITY	Serum insulin , glucose and non esterified fatty_acids after administration of follicle-stimulating and luteinizing hormones in bitches .
12800094	0	fatty_acids	78,89	insulin	23,30	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	oxidation|compound|START_ENTITY related|nmod|oxidation related|nsubjpass|resistance resistance|compound|END_ENTITY	Nicotinic_acid-induced insulin resistance is related to increased circulating fatty_acids and fat oxidation but not muscle lipid content .
12866995	0	fatty_acids	5,16	insulin	18,25	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	START_ENTITY|appos|resistance resistance|compound|END_ENTITY	Free fatty_acids , insulin resistance , and pregnancy .
14593613	0	fatty_acids	22,33	insulin	51,58	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	START_ENTITY|nmod|impairment impairment|nmod|secretion secretion|compound|END_ENTITY	-LSB- Contribution of free fatty_acids to impairment of insulin secretion and action : mechanism of beta-cell lipotoxicity -RSB- .
15334384	0	fatty_acids	34,45	insulin	49,56	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	In vivo regulation of plasma free fatty_acids in insulin resistance .
15334385	0	fatty_acids	32,43	insulin	119,126	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	profile|nmod|START_ENTITY unresponsive|nsubj|profile unresponsive|nmod|END_ENTITY	The multiphasic profile of free fatty_acids during the intravenous glucose tolerance test is unresponsive to exogenous insulin .
15334843	0	fatty_acids	31,42	insulin	57,64	fatty acids	insulin	MESH:D005227	493804(Tax:9685)	Chemical	Gene	START_ENTITY|nmod|indices indices|nmod|sensitivity sensitivity|compound|END_ENTITY	Assessment of the influence of fatty_acids on indices of insulin sensitivity and myocellular lipid content by use of magnetic resonance spectroscopy in cats .
15972273	0	fatty_acids	43,54	insulin	58,65	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	nonesterified|dobj|START_ENTITY nonesterified|nmod|END_ENTITY	On the suppression of plasma nonesterified fatty_acids by insulin during enhanced intravascular lipolysis in humans .
17127043	0	fatty_acids	224,235	insulin	10,17	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	intake|nmod|START_ENTITY effect|nsubj|intake oil|parataxis|effect oil|appos|sensitivity sensitivity|compound|END_ENTITY	Fish oil , insulin sensitivity , insulin secretion and glucose tolerance in healthy people : is there any effect of fish oil supplementation in relation to the type of background diet and habitual dietary intake of n-6 and n-3 fatty_acids ?
17127043	0	fatty_acids	224,235	insulin	31,38	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	intake|nmod|START_ENTITY effect|nsubj|intake oil|parataxis|effect oil|appos|secretion secretion|compound|END_ENTITY	Fish oil , insulin sensitivity , insulin secretion and glucose tolerance in healthy people : is there any effect of fish oil supplementation in relation to the type of background diet and habitual dietary intake of n-6 and n-3 fatty_acids ?
17327442	1	fatty_acids	226,237	insulin	264,271	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	oxidation|nmod|START_ENTITY switching|nmod|oxidation switching|nmod|END_ENTITY	Insulin resistance is associated with metabolic_inflexibility , impaired switching of substrate oxidation from fatty_acids to glucose in response to insulin .
17884459	0	fatty_acids	30,41	insulin	45,52	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	Contribution of nonesterified fatty_acids to insulin resistance in the elderly with normal fasting but diabetic 2-hour postchallenge plasma glucose levels : the Baltimore Longitudinal Study of Aging .
18826455	0	fatty_acids	8,19	insulin	42,49	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|resistance resistance|compound|END_ENTITY	Role of fatty_acids in the development of insulin resistance and type_2_diabetes_mellitus .
1884892	0	fatty_acids	15,26	insulin	48,55	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	contribute|nsubj|START_ENTITY contribute|nmod|resistance resistance|compound|END_ENTITY	Non-esterified fatty_acids do not contribute to insulin resistance in persons at increased risk of developing type 2 -LRB- non-insulin-dependent -RRB- diabetes mellitus .
1895958	0	fatty_acids	100,111	insulin	8,15	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	role|nmod|START_ENTITY uptake|dep|role uptake|amod|END_ENTITY	Forearm insulin - and non-insulin-mediated glucose uptake and muscle metabolism in man : role of free fatty_acids and blood glucose levels .
1943742	0	fatty_acids	105,116	insulin	42,49	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|concentrations concentrations|nmod|END_ENTITY	Effect of physiological concentrations of insulin and glucagon on the relationship between nonesterified fatty_acids availability and ketone body production in humans .
19671019	0	fatty_acids	42,53	insulin	62,69	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	actions|nmod|START_ENTITY actions|acl|causing causing|dobj|resistance resistance|compound|END_ENTITY	Direct and macrophage-mediated actions of fatty_acids causing insulin resistance in muscle cells .
19716144	0	fatty_acids	16,27	insulin	71,78	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	Addition|nmod|START_ENTITY affect|nsubj|Addition affect|dobj|sensitivity sensitivity|compound|END_ENTITY	Addition of n-3 fatty_acids to a 4-hour lipid infusion does not affect insulin sensitivity , insulin secretion , or markers of oxidative stress in subjects with type_2_diabetes_mellitus .
19915461	0	fatty_acids	31,42	insulin	46,53	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	The influence of major dietary fatty_acids on insulin secretion and action .
2058668	0	fatty_acids	13,24	insulin	36,43	fatty acids	insulin	MESH:D005227	100009181(Tax:9986)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|resistance resistance|compound|END_ENTITY	Role of free fatty_acids in hepatic insulin resistance during late pregnancy in conscious rabbits .
21489353	0	fatty_acids	5,16	insulin	45,52	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	level|compound|START_ENTITY effect|nsubj|level effect|dobj|secretion secretion|compound|END_ENTITY	Free fatty_acids level may effect a residual insulin secretion in type 1 diabetes .
21750413	0	fatty_acids	79,90	insulin	14,21	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	production|nmod|START_ENTITY secretion|dobj|production secretion|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of insulin secretion and reactive oxygen species production by free fatty_acids in pancreatic islets .
21956413	0	fatty_acids	112,123	insulin	10,17	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	changes|nmod|START_ENTITY independent|nmod|changes enhances|xcomp|independent enhances|nsubj|END_ENTITY	Exogenous insulin enhances glucose-stimulated insulin response in healthy humans independent of changes in free fatty_acids .
21956413	0	fatty_acids	112,123	insulin	46,53	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	changes|nmod|START_ENTITY independent|nmod|changes independent|nsubj|response response|compound|END_ENTITY	Exogenous insulin enhances glucose-stimulated insulin response in healthy humans independent of changes in free fatty_acids .
22609131	0	fatty_acids	62,73	insulin	25,32	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	role|nmod|START_ENTITY role|nmod|adiposity adiposity|nmod|resistance resistance|compound|END_ENTITY	From excess adiposity to insulin resistance : the role of free fatty_acids .
22977275	0	fatty_acids	56,67	insulin	10,17	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|infusion infusion|compound|END_ENTITY	Effect of insulin infusion on spillover of meal-derived fatty_acids .
23006812	0	fatty_acids	98,109	insulin	161,168	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	level|nmod|START_ENTITY level|dep|involvement involvement|nmod|resistance resistance|compound|END_ENTITY	Cardiac production of B-type_natriuretic_peptide is inversely related to the plasma level of free fatty_acids in obese individuals - possible involvement of the insulin resistance - .
23773230	0	fatty_acids	53,64	insulin	80,87	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	Ethnic - and sex-specific associations between plasma fatty_acids and markers of insulin resistance in healthy young adults .
2440143	0	fatty_acids	61,72	insulin	18,25	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	levels|nmod|START_ENTITY infusions|nmod|levels infusions|nsubj|Effects Effects|nmod|END_ENTITY	Effects of graded insulin infusions on plasma levels of free fatty_acids , adrenaline and noradrenaline directly after open heart surgery .
24675078	0	fatty_acids	59,70	insulin	141,148	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	metabolism|nmod|START_ENTITY underlies|nsubj|metabolism underlies|dobj|potentiation potentiation|nmod|secretion secretion|compound|END_ENTITY	Increased glucose metabolism and glycerolipid formation by fatty_acids and GPR40 receptor signaling underlies the fatty_acid potentiation of insulin secretion .
25139820	0	fatty_acids	115,126	insulin	71,78	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	roles|nmod|START_ENTITY Mitochondrial_dysfunction|dep|roles Mitochondrial_dysfunction|nmod|event event|nmod|resistance resistance|compound|END_ENTITY	Mitochondrial_dysfunction as a central event for mechanisms underlying insulin resistance : the roles of long chain fatty_acids .
25884071	0	fatty_acids	27,38	insulin	68,75	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	content|nmod|START_ENTITY -LSB-|dobj|content plasma|advcl|-LSB- plasma|nsubj|fatty_acids fatty_acids|compound|END_ENTITY	-LSB- The content of individual fatty_acids and numbers of double bonds , insulin , C-peptide and unesterified fatty_acids in blood plasma in testing tolerance to glucose -RSB- .
26415887	0	fatty_acids	12,23	insulin	27,34	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	role|nmod|START_ENTITY role|nmod|resistance resistance|compound|END_ENTITY	The role of fatty_acids in insulin resistance .
4719673	0	fatty_acids	52,63	insulin	15,22	fatty acids	insulin	MESH:D005227	483665(Tax:9615)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Stimulation Stimulation|nmod|END_ENTITY	Stimulation of insulin secretion by long-chain free fatty_acids .
4773550	0	fatty_acids	68,79	insulin	10,17	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	rate|nmod|START_ENTITY Action|nmod|rate Action|nmod|END_ENTITY	Action of insulin and glucose on the re-esterification rate of free fatty_acids in isolated human fat cells .
5051799	0	fatty_acids	58,69	insulin	32,39	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	quality|nmod|START_ENTITY END_ENTITY|nmod|quality	In vitro and in vivo effects of insulin on the quality of fatty_acids synthesized by adipose tissue .
5822597	0	fatty_acids	53,64	insulin	15,22	fatty acids	insulin	MESH:D005227	483665(Tax:9615)	Chemical	Gene	infusion|nmod|START_ENTITY secretion|nmod|infusion secretion|nsubj|Stimulation Stimulation|nmod|END_ENTITY	Stimulation of insulin secretion by infusion of free fatty_acids .
6117512	0	fatty_acids	56,67	insulin	78,85	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	START_ENTITY|nmod|withdrawal withdrawal|compound|END_ENTITY	Retardant effect of hyperglycemia on the rise in plasma fatty_acids following insulin withdrawal in man .
6342507	0	fatty_acids	50,61	insulin	16,23	fatty acids	insulin	MESH:D005227	100009181(Tax:9986)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	-LSB- Stimulation of insulin secretion by medium-chain fatty_acids in the diet of young rabbits -RSB- .
6348062	0	fatty_acids	76,87	insulin	168,175	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	triglycerides|nmod|START_ENTITY substitution|nmod|triglycerides substitution|dep|effects effects|nmod|resistance resistance|compound|END_ENTITY	Eucaloric substitution of medium chain triglycerides for dietary long chain fatty_acids in acquired total_lipodystrophy : effects on hyperlipoproteinemia and endogenous insulin resistance .
6382374	0	fatty_acids	71,82	insulin	86,93	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	nonesterified|dobj|START_ENTITY nonesterified|nmod|END_ENTITY	Differential response of plasma glucose , amino_acids and nonesterified fatty_acids to insulin in depressed patients .
687537	0	fatty_acids	11,22	insulin	24,31	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	START_ENTITY|appos|glucose glucose|compound|END_ENTITY	Serum free fatty_acids , insulin and blood glucose in pregnancy .
6991278	0	fatty_acids	51,62	insulin	10,17	fatty acids	insulin	MESH:D005227	396145(Tax:9031)	Chemical	Gene	synthesis|nmod|START_ENTITY vivo|nmod|synthesis END_ENTITY|nmod|vivo	Effect of insulin in vivo on the synthesis of free fatty_acids -LRB- FFA -RRB- in chicken heart and skeletal muscle .
7011721	0	fatty_acids	87,98	insulin	139,146	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	START_ENTITY|nmod|comparison comparison|nmod|END_ENTITY	Biosynthetic human insulin : effect in healthy men on plasma glucose and non-esterified fatty_acids in comparison with highly purified pork insulin .
7806018	0	fatty_acids	183,194	insulin	104,111	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	resistance|nmod|START_ENTITY secretion|appos|resistance secretion|compound|END_ENTITY	Hypertriglyceridaemia in subjects with normal and abnormal glucose tolerance : relative contributions of insulin secretion , insulin resistance and suppression of plasma non-esterified fatty_acids .
7806018	0	fatty_acids	183,194	insulin	123,130	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	resistance|nmod|START_ENTITY resistance|compound|END_ENTITY	Hypertriglyceridaemia in subjects with normal and abnormal glucose tolerance : relative contributions of insulin secretion , insulin resistance and suppression of plasma non-esterified fatty_acids .
8060375	0	fatty_acids	117,128	insulin	75,82	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	START_ENTITY|nsubj|Relationships Relationships|nmod|tissue tissue|compound|END_ENTITY	Relationships of plasminogen_activator_inhibitor-1 to anthropometry , serum insulin , triglycerides and adipose tissue fatty_acids in healthy men .
874045	0	fatty_acids	74,85	insulin	48,55	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	START_ENTITY|compound|glucose glucose|compound|END_ENTITY	Somatostatin modulation of pancreatic glucagon , insulin , glucose and free fatty_acids following beta-adrenergic stimulation .
9000693	0	fatty_acids	12,23	insulin	63,70	fatty acids	insulin	MESH:D005227	483665(Tax:9615)	Chemical	Gene	START_ENTITY|acl|mediating mediating|dobj|effects effects|nmod|END_ENTITY	The role of fatty_acids in mediating the effects of peripheral insulin on hepatic glucose production in the conscious dog .
9566856	0	fatty_acids	70,81	insulin	23,30	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	suppression|nmod|START_ENTITY mediated|dobj|suppression mediated|nsubj|END_ENTITY	Body fat distribution , insulin mediated suppression of non-esterified fatty_acids and plasma triglycerides in obese subjects .
9688888	0	fatty_acids	13,24	insulin	66,73	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|effect effect|nmod|END_ENTITY	Role of free fatty_acids and glucagon in the peripheral effect of insulin on glucose production in humans .
9794097	0	fatty_acids	9,20	insulin	39,46	fatty acids	insulin	MESH:D005227	3630	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|response response|compound|END_ENTITY	Lowering fatty_acids potentiates acute insulin response in first degree relatives of people with type_II_diabetes .
12427655	0	fatty_acids	122,133	interleukin-8	67,80	fatty acids	interleukin-8	MESH:D005227	3576	Chemical	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Enzymatically modified nonoxidized low-density lipoprotein induces interleukin-8 in human endothelial cells : role of free fatty_acids .
8218196	0	fatty_acids	49,60	interphotoreceptor_retinoid-binding_protein	66,109	fatty acids	interphotoreceptor retinoid-binding protein	MESH:D005227	5949	Chemical	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of all-trans-retinol and long-chain fatty_acids with interphotoreceptor_retinoid-binding_protein .
1010852	0	fatty_acids	11,22	lecithin-cholesterol_acyltransferase	51,87	fatty acids	lecithin-cholesterol acyltransferase	MESH:D005227	3931	Chemical	Gene	Release|nmod|START_ENTITY Release|nmod|END_ENTITY	Release of fatty_acids from phosphatidylcholine by lecithin-cholesterol_acyltransferase .
10490795	0	fatty_acids	5,16	leptin	53,59	fatty acids	leptin	MESH:D005227	3952	Chemical	Gene	START_ENTITY|dep|relationship relationship|acl|END_ENTITY	Free fatty_acids and insulin levels -- relationship to leptin levels and body composition in various patient groups from South Africa .
12736159	0	fatty_acids	61,72	leptin	14,20	fatty acids	leptin	MESH:D005227	25608(Tax:10116)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of leptin secretion from white adipocytes by free fatty_acids .
14722361	0	fatty_acids	12,23	leptin	34,40	fatty acids	leptin	MESH:D005227	16846(Tax:10090)	Chemical	Gene	START_ENTITY|xcomp|stimulate stimulate|dobj|production production|compound|END_ENTITY	Short-chain fatty_acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41 .
24931281	0	fatty_acids	81,92	leptin	94,100	fatty acids	leptin	MESH:D005227	3952	Chemical	Gene	intensity|appos|START_ENTITY intensity|appos|END_ENTITY	Lactation intensity and fasting plasma lipids , lipoproteins , non-esterified free fatty_acids , leptin and adiponectin in postpartum women with recent_gestational_diabetes_mellitus : the SWIFT cohort .
9385619	0	fatty_acids	64,75	leptin	24,30	fatty acids	leptin	MESH:D005227	3952	Chemical	Gene	START_ENTITY|nsubj|Relationships Relationships|nmod|levels levels|compound|END_ENTITY	Relationships of plasma leptin levels to changes in plasma free fatty_acids in women who are lean and women who are abdominally obese .
9647748	0	fatty_acids	20,31	leptin	43,49	fatty acids	leptin	MESH:D005227	3952	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of free fatty_acids with human leptin .
1539648	0	fatty_acids	5,16	lipoprotein_lipase	32,50	fatty acids	lipoprotein lipase	MESH:D005227	24539(Tax:10116)	Chemical	Gene	release|nsubj|START_ENTITY release|dobj|END_ENTITY	Free fatty_acids do not release lipoprotein_lipase from isolated cardiac myocytes or perfused hearts .
8121293	0	fatty_acids	11,22	lipoprotein_lipase	32,50	fatty acids	lipoprotein lipase	MESH:D005227	24539(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|activity activity|compound|END_ENTITY	Long-chain fatty_acids decrease lipoprotein_lipase activity of cultured rat adipocyte precursors .
11171094	0	fatty_acids	11,22	liver_carnitine_palmitoyltransferase_I	32,70	fatty acids	liver carnitine palmitoyltransferase I	MESH:D005227	12894(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|expression expression|amod|END_ENTITY	Long-chain fatty_acids regulate liver_carnitine_palmitoyltransferase_I gene -LRB- L-CPT_I -RRB- expression through a peroxisome-proliferator-activated_receptor_alpha -LRB- PPARalpha -RRB- - independent pathway .
1556178	0	fatty_acids	36,47	low_density_lipoprotein_receptor	76,108	fatty acids	low density lipoprotein receptor	MESH:D005227	3949	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Regulatory effects of the saturated fatty_acids 6:0 through 18:0 on hepatic low_density_lipoprotein_receptor activity in the hamster .
7109856	0	fatty_acids	27,38	milk	61,65	fatty acids	milk	MESH:D005227	100532204	Chemical	Gene	distribution|nmod|START_ENTITY distribution|nmod|END_ENTITY	Positional distribution of fatty_acids in triglycerides from milk of several species of mammals .
7273104	0	fatty_acids	25,36	mucin	55,60	fatty acids	mucin	MESH:D005227	65202(Tax:10116)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|release release|compound|END_ENTITY	Influence of short-chain fatty_acids and osmolality on mucin release in the rat colon .
20801654	0	fatty_acids	26,37	myeloperoxidase	70,85	fatty acids	myeloperoxidase	MESH:D005227	4353	Chemical	Gene	START_ENTITY|nmod|the the|nmod|END_ENTITY	Effect of unsaturation in fatty_acids on the binding and oxidation by myeloperoxidase : ramifications for the initiation of atherosclerosis .
11694645	0	fatty_acids	12,23	p53	102,105	fatty acids	p53	MESH:D005227	7157	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|advcl|modulating modulating|dobj|expression expression|compound|END_ENTITY	Short-chain fatty_acids inhibit invasive human colon_cancer by modulating uPA , TIMP-1 , TIMP-2 , mutant p53 , Bcl-2 , Bax , p21 and PCNA protein expression in an in vitro cell culture model .
16981429	0	fatty_acids	36,47	p53	79,82	fatty acids	p53	MESH:D005227	7157	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	The inhibitory action of long-chain fatty_acids on the DNA binding activity of p53 .
26438057	0	fatty_acids	93,104	p53	28,31	fatty acids	p53	MESH:D005227	7157	Chemical	Gene	overload|compound|START_ENTITY case|nmod|overload homeostasis|nmod|case role|nmod|homeostasis has|dobj|role has|nsubj|Y220C Y220C|nmod|protein protein|compound|END_ENTITY	Core domain mutant Y220C of p53 protein has a key role in copper homeostasis in case of free fatty_acids overload .
3841263	0	fatty_acids	53,64	peptide_YY	37,47	fatty acids	peptide YY	MESH:D005227	607156(Tax:9615)	Chemical	Gene	distribution|nmod|START_ENTITY distribution|nmod|END_ENTITY	Regional distribution and release of peptide_YY with fatty_acids of different chain length .
9541126	2	fatty_acids	820,831	peptide_YY	867,877	fatty acids	peptide YY	MESH:D005227	5697	Chemical	Gene	quantity|appos|START_ENTITY increased|nsubj|quantity increased|dobj|concentration concentration|nmod|END_ENTITY	A smaller quantity of long-chain triglycerides -LRB- 90 mmol fatty_acids -RRB- increased plasma concentration of peptide_YY from 7.4 pmol L -LRB- -1 -RRB- -LRB- SEM 0.4 , n = 8 -RRB- to 13.3 pmol L -LRB- -1 -RRB- -LRB- SEM 1.5 , n = 8 -RRB- , whereas sucrose_polyester -LRB- 90 mmol fatty_acids -RRB- did not change peptide_YY concentration .
9541126	2	fatty_acids	983,994	peptide_YY	867,877	fatty acids	peptide YY	MESH:D005227	5697	Chemical	Gene	sucrose_polyester|appos|START_ENTITY change|nsubj|sucrose_polyester increased|advcl|change increased|dobj|concentration concentration|nmod|END_ENTITY	A smaller quantity of long-chain triglycerides -LRB- 90 mmol fatty_acids -RRB- increased plasma concentration of peptide_YY from 7.4 pmol L -LRB- -1 -RRB- -LRB- SEM 0.4 , n = 8 -RRB- to 13.3 pmol L -LRB- -1 -RRB- -LRB- SEM 1.5 , n = 8 -RRB- , whereas sucrose_polyester -LRB- 90 mmol fatty_acids -RRB- did not change peptide_YY concentration .
21176858	0	fatty_acids	134,145	peptidoglycan_recognition_protein_3	16,51	fatty acids	peptidoglycan recognition protein 3	MESH:D005227	114771	Chemical	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	PPARy-dependent peptidoglycan_recognition_protein_3 -LRB- PGlyRP3 -RRB- expression regulates proinflammatory cytokines by microbial and dietary fatty_acids .
15525607	0	fatty_acids	27,38	peroxisome_proliferator-activated_receptor	51,93	fatty acids	peroxisome proliferator-activated receptor	MESH:D005227	5465	Chemical	Gene	Suppression|nmod|START_ENTITY upregulates|nsubj|Suppression upregulates|dobj|END_ENTITY	Suppression of plasma free fatty_acids upregulates peroxisome_proliferator-activated_receptor -LRB- PPAR -RRB- alpha and delta and PPAR coactivator 1alpha in human skeletal muscle , but not lipid regulatory genes .
23365010	0	fatty_acids	53,64	peroxisome_proliferator-activated_receptor	74,116	fatty acids	peroxisome proliferator-activated receptor	MESH:D005227	5465	Chemical	Gene	START_ENTITY|xcomp|regulate regulate|xcomp|responsive responsive|nsubj|subtypes subtypes|amod|END_ENTITY	Conjugated linoleic_acid isomers and their precursor fatty_acids regulate peroxisome_proliferator-activated_receptor subtypes and major peroxisome proliferator responsive element-bearing target genes in HepG2 cell model .
23766515	0	fatty_acids	102,113	peroxisome_proliferator-activated_receptor	37,79	fatty acids	peroxisome proliferator-activated receptor	MESH:D005227	19013(Tax:10090)	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nmod|END_ENTITY	Sphingosine_kinase_1 is regulated by peroxisome_proliferator-activated_receptor a in response to free fatty_acids and is essential for skeletal muscle interleukin-6 production and signaling in diet-induced obesity .
8240670	0	fatty_acids	95,106	peroxisome_proliferator-activated_receptor	4,46	fatty acids	peroxisome proliferator-activated receptor	MESH:D005227	25747(Tax:10116)	Chemical	Gene	activated|nmod|START_ENTITY retinoid|ccomp|activated retinoid|nsubj|END_ENTITY	The peroxisome_proliferator-activated_receptor : retinoid X receptor heterodimer is activated by fatty_acids and fibrate hypolipidaemic drugs .
12196468	0	fatty_acids	132,143	peroxisome_proliferator-activated_receptor-gamma	159,207	fatty acids	peroxisome proliferator-activated receptor-gamma	MESH:D005227	25664(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|amod|END_ENTITY	Role of ATP production and uncoupling_protein-2 in the insulin secretory defect induced by chronic exposure to high glucose or free fatty_acids and effects of peroxisome_proliferator-activated_receptor-gamma inhibition .
18466197	0	fatty_acids	12,23	peroxisome_proliferator-activated_receptor-gamma	80,128	fatty acids	peroxisome proliferator-activated receptor-gamma	MESH:D005227	5468	Chemical	Gene	attenuate|nsubj|START_ENTITY attenuate|advcl|activating activating|dobj|END_ENTITY	Dietary n-3 fatty_acids attenuate cardiac_allograft_vasculopathy via activating peroxisome_proliferator-activated_receptor-gamma .
10777541	0	fatty_acids	114,125	peroxisome_proliferator-activated_receptor_alpha	139,187	fatty acids	peroxisome proliferator-activated receptor alpha	MESH:D005227	5465	Chemical	Gene	START_ENTITY|acl|mediated mediated|nmod|END_ENTITY	The murine and human cholesterol_7alpha-hydroxylase gene promoters are differentially responsive to regulation by fatty_acids mediated via peroxisome_proliferator-activated_receptor_alpha .
19013096	0	fatty_acids	13,24	peroxisome_proliferator-activated_receptors	62,105	fatty acids	peroxisome proliferator-activated receptors	MESH:D005227	5465	Chemical	Gene	Role|nmod|START_ENTITY Role|dep|involvement involvement|nmod|END_ENTITY	-LSB- Role of the fatty_acids in ovarian functions : involvement of peroxisome_proliferator-activated_receptors -LRB- PPAR -RRB- and adipokines -RSB- .
12506134	0	fatty_acids	64,75	peroxisome_proliferator_activated_receptor-gamma	88,136	fatty acids	peroxisome proliferator activated receptor-gamma	MESH:D005227	5468	Chemical	Gene	START_ENTITY|acl|mediated mediated|nmod|END_ENTITY	Stimulation of proximal tubular cell apoptosis by albumin-bound fatty_acids mediated by peroxisome_proliferator_activated_receptor-gamma .
11968005	0	fatty_acids	120,131	phosphoenolpyruvate_carboxykinase	36,69	fatty acids	phosphoenolpyruvate carboxykinase	MESH:D005227	362282(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Evidence for selective induction of phosphoenolpyruvate_carboxykinase gene expression by unsaturated and nonmetabolized fatty_acids in adipocytes .
8074682	0	fatty_acids	68,79	phosphoenolpyruvate_carboxykinase	15,48	fatty acids	phosphoenolpyruvate carboxykinase	MESH:D005227	5106	Chemical	Gene	Stimulation|nmod|START_ENTITY Stimulation|nmod|expression expression|amod|END_ENTITY	Stimulation of phosphoenolpyruvate_carboxykinase gene expression by fatty_acids .
347651	0	fatty_acids	48,59	phospholipase_A	18,33	fatty acids	phospholipase A	MESH:D005227	57110	Chemical	Gene	START_ENTITY|nsubj|generation generation|nmod|END_ENTITY	The generation of phospholipase_A and hemolytic fatty_acids by autolysing suspensions of Trypanosoma congolense .
11370672	0	fatty_acids	56,67	phospholipase_A2	118,134	fatty acids	phospholipase A2	MESH:D005227	18784(Tax:10090)	Chemical	Gene	release|nmod|START_ENTITY exerts|nmod|release exerts|parataxis|lack lack|nmod|activation activation|nmod|END_ENTITY	Melittin exerts multiple effects on the release of free fatty_acids from L1210 cells : lack of selective activation of phospholipase_A2 by melittin .
12777475	0	fatty_acids	50,61	phospholipase_A2	23,39	fatty acids	phospholipase A2	MESH:D005227	18784(Tax:10090)	Chemical	Gene	supply|dobj|START_ENTITY END_ENTITY|xcomp|supply	Oxidized LDL activates phospholipase_A2 to supply fatty_acids required for cholesterol esterification .
14577330	0	fatty_acids	50,61	phospholipase_A2	16,32	fatty acids	phospholipase A2	MESH:D005227	18784(Tax:10090)	Chemical	Gene	supply|nmod|START_ENTITY END_ENTITY|nmod|supply	-LSB- Involvement of phospholipase_A2 in the supply of fatty_acids required for cholesterol_esterification associated with uptake of oxidized low-density lipoprotein in macrophages -RSB- .
2163589	0	fatty_acids	43,54	phospholipase_A2	80,96	fatty acids	phospholipase A2	MESH:D005227	151056	Chemical	Gene	nanomoles|nmod|START_ENTITY estimation|nmod|nanomoles estimation|dep|use use|nmod|assay assay|nmod|activity activity|amod|END_ENTITY	AT32P-dependent estimation of nanomoles of fatty_acids : its use in the assay of phospholipase_A2 activity .
9812904	0	fatty_acids	12,23	plasminogen_activator_inhibitor-1	33,66	fatty acids	plasminogen activator inhibitor-1	MESH:D005227	5054	Chemical	Gene	increase|nsubj|START_ENTITY increase|dobj|expression expression|amod|END_ENTITY	Unsaturated fatty_acids increase plasminogen_activator_inhibitor-1 expression in endothelial cells .
1352441	0	fatty_acids	21,32	protein_kinase_C	36,52	fatty acids	protein kinase C	MESH:D005227	24681(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Action of long-chain fatty_acids on protein_kinase_C activity : comparison of omega-6 and omega-3 fatty_acids .
24107614	0	fatty_acids	5,16	protein_tyrosine_phosphatase_1B	25,56	fatty acids	protein tyrosine phosphatase 1B	MESH:D005227	5770	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|END_ENTITY	Free fatty_acids inhibit protein_tyrosine_phosphatase_1B and activate Akt .
17947500	0	fatty_acids	42,53	pyruvate_dehydrogenase	79,101	fatty acids	pyruvate dehydrogenase	MESH:D005227	54704	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	The acute effects of differential dietary fatty_acids on human skeletal muscle pyruvate_dehydrogenase activity .
11741341	0	fatty_acids	109,120	resistin	40,48	fatty acids	resistin	MESH:D005227	246250(Tax:10116)	Chemical	Gene	Suppressed|nmod|START_ENTITY Suppressed|dobj|expression expression|nmod|END_ENTITY	Suppressed gene expression of adipocyte resistin in an insulin-resistant rat model probably by elevated free fatty_acids .
16125524	0	fatty_acids	16,27	resistin	38,46	fatty acids	resistin	MESH:D005227	246250(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of free fatty_acids on plasma resistin and insulin resistance in awake rats .
2529919	0	fatty_acids	82,93	rhodopsin	53,62	fatty acids	rhodopsin	MESH:D005227	6010	Chemical	Gene	Study|nmod|START_ENTITY Study|nmod|END_ENTITY	-LSB- Study of thermo-stabilizing effect of tocopherol on rhodopsin in the presence of fatty_acids using the method of differential scanning calorimetry -RSB- .
6149447	0	fatty_acids	71,82	somatostatin	14,26	fatty acids	somatostatin	MESH:D005227	6750	Chemical	Gene	role|nmod|START_ENTITY study|nmod|role Regulation|dep|study Regulation|nmod|secretion secretion|compound|END_ENTITY	Regulation of somatostatin secretion in man : study of the role of free fatty_acids and ketone bodies .
8097916	0	fatty_acids	16,27	somatostatin	31,43	fatty acids	somatostatin	MESH:D005227	24797(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|compound|END_ENTITY	Effects of free fatty_acids on somatostatin secretion , content and mRNA levels in cortical and hypothalamic fetal rat neurones in monolayer culture .
19800043	0	fatty_acids	46,57	testicular_orphan_receptor_4	14,42	fatty acids	testicular orphan receptor 4	MESH:D005227	22026(Tax:10090)	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of testicular_orphan_receptor_4 by fatty_acids .
19056662	0	fatty_acids	12,23	transient_receptor_potential_vanilloid_type_6	42,87	fatty acids	transient receptor potential vanilloid type 6	MESH:D005227	114246(Tax:10116)	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|amod|END_ENTITY	Short-chain fatty_acids induce intestinal transient_receptor_potential_vanilloid_type_6 expression in rats and Caco-2 cells .
14642773	0	fatty_acids	62,73	triacylglycerol_hydrolase	14,39	fatty acids	triacylglycerol hydrolase	MESH:D005227	104158(Tax:10090)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of triacylglycerol_hydrolase expression by dietary fatty_acids and peroxisomal_proliferator-activated_receptors .
17405916	0	fatty_acids	149,160	tumor_necrosis_factor-alpha	62,89	fatty acids	tumor necrosis factor-alpha	MESH:D005227	24835(Tax:10116)	Chemical	Gene	absence|nmod|START_ENTITY cultures|nmod|absence END_ENTITY|nmod|cultures	Upregulation of apolipoprotein_B secretion , but not lipid , by tumor_necrosis_factor-alpha in rat hepatocyte cultures in the absence of extracellular fatty_acids .
1871180	0	fatty_acids	34,45	tumor_necrosis_factor-alpha	49,76	fatty acids	tumor necrosis factor-alpha	MESH:D005227	24835(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	The effect of dietary n-3 and n-6 fatty_acids on tumor_necrosis_factor-alpha production and leucine_aminopeptidase levels in rat peritoneal macrophages .
3577767	0	fatty_acids	15,26	tumour_necrosis_factor	56,78	fatty acids	tumour necrosis factor	MESH:D005227	21926(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of free fatty_acids on the cytolytic activity of tumour_necrosis_factor / monocyte-derived cytotoxic factor .
7772629	0	fatty_acids	191,202	tumour_necrosis_factor	84,106	fatty acids	tumour necrosis factor	MESH:D005227	100135630(Tax:10141)	Chemical	Gene	vitro|nmod|START_ENTITY incubated|advcl|vitro macrophages|acl|incubated treated|nmod|macrophages treated|nmod|production production|nmod|END_ENTITY	Effect of hepatocytes from normal or endotoxin treated animals on the production of tumour_necrosis_factor , interleukin-6 , and prostaglandin-E2 by macrophages incubated in vitro with various fatty_acids .
10393216	0	fatty_acids	90,101	tyrosinase	51,61	fatty acids	tyrosinase	MESH:D005227	22173(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY involvement|nmod|effect involvement|nmod|END_ENTITY	Possible involvement of proteolytic degradation of tyrosinase in the regulatory effect of fatty_acids on melanogenesis .
20544305	0	fatty_acids	22,33	tyrosinase	62,72	fatty acids	tyrosinase	MESH:D005227	7299	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nsubj|effects	Inhibitory effects of fatty_acids on the activity of mushroom tyrosinase .
16219387	0	fatty_acids	12,23	tyrosine_hydroxylase	33,53	fatty acids	tyrosine hydroxylase	MESH:D005227	7054	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|amod|END_ENTITY	Short chain fatty_acids regulate tyrosine_hydroxylase gene expression through a cAMP-dependent signaling pathway .
11694645	0	fatty_acids	12,23	uPA	74,77	fatty acids	uPA	MESH:D005227	5328	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|advcl|modulating modulating|dobj|expression expression|compound|END_ENTITY	Short-chain fatty_acids inhibit invasive human colon_cancer by modulating uPA , TIMP-1 , TIMP-2 , mutant p53 , Bcl-2 , Bax , p21 and PCNA protein expression in an in vitro cell culture model .
11564673	0	fatty_acids	57,68	uncoupling_protein_3	17,37	fatty acids	uncoupling protein 3	MESH:D005227	7352	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Up-regulation of uncoupling_protein_3 gene expression by fatty_acids and agonists for PPARs in L6 myotubes .
9519732	0	fatty_acids	14,25	uncoupling_protein_3	33,53	fatty acids	uncoupling protein 3	MESH:D005227	7352	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|amod|END_ENTITY	Elevated free fatty_acids induce uncoupling_protein_3 expression in muscle : a potential explanation for the effect of fasting .
9070922	0	fatty_aldehyde	6,20	ALDH10	41,47	fatty aldehyde	ALDH10	MESH:C001634	224	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Human fatty_aldehyde dehydrogenase gene -LRB- ALDH10 -RRB- : organization and tissue-dependent expression .
15931689	0	fatty_aldehyde	75,89	ALDH3A2	110,117	fatty aldehyde	ALDH3A2	MESH:C001634	224	Chemical	Gene	dehydrogenase|amod|START_ENTITY gene|amod|dehydrogenase gene|appos|END_ENTITY	Sj __ gren-Larsson_syndrome : diversity of mutations and polymorphisms in the fatty_aldehyde dehydrogenase gene -LRB- ALDH3A2 -RRB- .
26771445	0	febuxostat	28,38	HLA-B	56,61	febuxostat	HLA-B	MESH:C084623	3106	Chemical	Gene	START_ENTITY|nmod|treatment treatment|nmod|END_ENTITY	Safety and efficacy of oral febuxostat for treatment of HLA-B * 5801-negative gout : a randomized , open-label , multicentre , allopurinol-controlled study .
18995179	0	febuxostat	33,43	Xanthine_oxidase	0,16	febuxostat	Xanthine oxidase	MESH:C084623	22436(Tax:10090)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Xanthine_oxidase inhibition with febuxostat attenuates systolic overload-induced left_ventricular_hypertrophy_and_dysfunction in mice .
24686534	0	febuxostat	31,41	Xanthine_oxidase	0,16	febuxostat	Xanthine oxidase	MESH:C084623	22436(Tax:10090)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Xanthine_oxidase inhibition by febuxostat attenuates experimental atherosclerosis in mice .
8880744	0	felbamate	34,43	CA1	77,80	felbamate	CA1	MESH:C047360	310218(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|region region|compound|END_ENTITY	Effects of the antiepileptic drug felbamate on long-term potentiation in the CA1 region of rat hippocampal slices .
7682512	0	felodipine	11,21	Ca2	61,64	felodipine	Ca2	MESH:D015736	54231(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|+ +|amod|END_ENTITY	Effects of felodipine , nifedipine and verapamil on cytosolic Ca2 + and contraction in vascular smooth muscle .
8382239	0	felodipine	64,74	calcium-binding_proteins	25,49	felodipine	calcium-binding proteins	MESH:D015736	24249(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Alterations Alterations|nmod|END_ENTITY	Alterations in cytosolic calcium-binding_proteins that increase felodipine fluorescence in spontaneously hypertensive rats .
9613405	0	felodipine	14,24	endothelin-1	28,40	felodipine	endothelin-1	MESH:D015736	1906	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|levels levels|amod|END_ENTITY	The effect of felodipine on endothelin-1 levels , peripheral vasoconstriction and flap survival during microvascular breast reconstruction .
22397757	0	felotaxel	77,86	cytochrome_P450	23,38	felotaxel	cytochrome P450	MESH:C571875	4051	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	In vitro assessment of cytochrome_P450 inhibition and induction potential of felotaxel -LRB- SHR110008 -RRB- .
19888597	0	fenamate	32,40	TRPA1	14,19	fenamate	TRPA1	null	8989	Chemical	Gene	channels|nmod|START_ENTITY channels|nummod|END_ENTITY	Activation of TRPA1 channels by fenamate nonsteroidal anti-inflammatory drugs .
19899158	0	fenamiphos	89,99	acetylcholinesterase	34,54	fenamiphos	acetylcholinesterase	MESH:C002698	83817(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|interaction interaction|nmod|END_ENTITY	Enantioselective interaction with acetylcholinesterase of an organophosphate insecticide fenamiphos .
3623815	0	fenfluramine	21,33	P300	41,45	fenfluramine	P300	MESH:D005277	2033	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|component component|compound|END_ENTITY	No effect of chronic fenfluramine on the P300 component of the event-related potential .
12689612	0	fenfluramine	22,34	Prolactin	0,9	fenfluramine	Prolactin	MESH:D005277	5617	Chemical	Gene	administration|amod|START_ENTITY response|nmod|administration response|compound|END_ENTITY	Prolactin response to fenfluramine administration in patients with unipolar and bipolar_depression and healthy controls .
18279498	0	fenfluramine	22,34	Prolactin	0,9	fenfluramine	Prolactin	MESH:D005277	5617	Chemical	Gene	START_ENTITY|nsubj|response response|compound|END_ENTITY	Prolactin response to fenfluramine in abstinent , alcohol-dependent patients .
8513038	0	fenfluramine	22,34	Prolactin	0,9	fenfluramine	Prolactin	MESH:D005277	5617	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Prolactin response to fenfluramine and placebo challenge following maintenance pharmacotherapy withdrawal in remitted depressed patients .
8645775	0	fenfluramine	36,48	Prolactin	0,9	fenfluramine	Prolactin	MESH:D005277	5617	Chemical	Gene	responses|acl|START_ENTITY responses|amod|END_ENTITY	Prolactin and cortisol responses to fenfluramine challenge in mania .
8833686	0	fenfluramine	22,34	Prolactin	0,9	fenfluramine	Prolactin	MESH:D005277	5617	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Prolactin response to fenfluramine and suicide attempt lethality in major depression .
8894070	0	fenfluramine	36,48	Prolactin	0,9	fenfluramine	Prolactin	MESH:D005277	5617	Chemical	Gene	START_ENTITY|nsubj|responses responses|compound|END_ENTITY	Prolactin and cortisol responses to fenfluramine in Parkinson 's _ disease .
8894606	0	fenfluramine	22,34	Prolactin	0,9	fenfluramine	Prolactin	MESH:D005277	24683(Tax:10116)	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Prolactin response to fenfluramine is independent of serotonin release .
2977280	0	fenfluramine	44,56	beta-endorphin	26,40	fenfluramine	beta-endorphin	MESH:D005277	5443	Chemical	Gene	Reduction|nmod|START_ENTITY Reduction|nmod|END_ENTITY	Reduction of elevated CSF beta-endorphin by fenfluramine in infantile autism .
1020921	0	fenfluramine	11,23	growth_hormone	46,60	fenfluramine	growth hormone	MESH:D005277	2688	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|amod|END_ENTITY	Effects of fenfluramine and cyproheptadine on growth_hormone secretion .
1870427	0	fenfluramine	151,163	growth_hormone	8,22	fenfluramine	growth hormone	MESH:D005277	2688	Chemical	Gene	administration|nmod|START_ENTITY influence|nmod|administration GH-releasing_hormone|dep|influence responsiveness|nmod|GH-releasing_hormone responsiveness|nsubj|END_ENTITY	Blunted growth_hormone -LRB- GH -RRB- responsiveness to GH-releasing_hormone in obese patients : influence of prolonged administration of the serotoninergic drug fenfluramine .
2112069	0	fenfluramine	125,137	growth_hormone	9,23	fenfluramine	growth hormone	MESH:D005277	2688	Chemical	Gene	administration|amod|START_ENTITY blocked|nmod|administration restoration|acl|blocked response|dep|restoration response|compound|END_ENTITY	Impaired growth_hormone response to insulin-induced hypoglycaemia in obese patients : restoration blocked by ritanserin after fenfluramine administration .
3436616	0	fenfluramine	10,22	growth_hormone	26,40	fenfluramine	growth hormone	MESH:D005277	2688	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of fenfluramine on growth_hormone and prolactin secretion in obese subjects .
4704518	0	fenfluramine	10,22	growth_hormone	32,46	fenfluramine	growth hormone	MESH:D005277	2688	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|release release|compound|END_ENTITY	Effect of fenfluramine on human growth_hormone release .
10480671	0	fenfluramine	26,38	prolactin	4,13	fenfluramine	prolactin	MESH:D005277	5617	Chemical	Gene	response|acl|START_ENTITY response|compound|END_ENTITY	The prolactin response to fenfluramine in schizophrenia is associated with negative symptoms .
12680745	0	fenfluramine	26,38	prolactin	4,13	fenfluramine	prolactin	MESH:D005277	5617	Chemical	Gene	response|acl|START_ENTITY response|amod|END_ENTITY	The prolactin response to fenfluramine in depression : effects of melancholia and baseline cortisol .
2501208	0	fenfluramine	11,23	prolactin	42,51	fenfluramine	prolactin	MESH:D005277	5617	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|response response|compound|END_ENTITY	Effects of fenfluramine and ritanserin on prolactin response to insulin-induced hypoglycemia in obese patients : evidence for failure of the serotoninergic system .
2521644	0	fenfluramine	60,72	prolactin	38,47	fenfluramine	prolactin	MESH:D005277	5617	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Effect of imipramine treatment on the prolactin response to fenfluramine and placebo challenge in depressed patients .
2931613	0	fenfluramine	129,141	prolactin	87,96	fenfluramine	prolactin	MESH:D005277	24683(Tax:10116)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|studies studies|nmod|stimulation stimulation|nmod|END_ENTITY	Pharmacological studies on the serotoninergic and nonserotonin-mediated stimulation of prolactin and corticosterone secretion by fenfluramine .
3988149	0	fenfluramine	10,22	prolactin	52,61	fenfluramine	prolactin	MESH:D005277	5617	Chemical	Gene	administration|amod|START_ENTITY Effect|nmod|administration Effect|nmod|levels levels|compound|END_ENTITY	Effect of fenfluramine oral administration on serum prolactin levels in healthy and hyperprolactinemic women .
548046	0	fenfluramine	78,90	prolactin	27,36	fenfluramine	prolactin	MESH:D005277	5617	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Changes Changes|nmod|titres titres|nmod|END_ENTITY	Changes in serum titres of prolactin , somatotropin and thyrotropin induced by fenfluramine in humans .
6360431	0	fenfluramine	10,22	prolactin	107,116	fenfluramine	prolactin	MESH:D005277	5617	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|evidence evidence|nmod|regulation regulation|nmod|END_ENTITY	Effect of fenfluramine on prolactin secretion in obese patients : evidence for serotoninergic regulation of prolactin in man .
6360431	0	fenfluramine	10,22	prolactin	26,35	fenfluramine	prolactin	MESH:D005277	5617	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Effect of fenfluramine on prolactin secretion in obese patients : evidence for serotoninergic regulation of prolactin in man .
6700367	0	fenfluramine	35,47	prolactin	7,16	fenfluramine	prolactin	MESH:D005277	5617	Chemical	Gene	changes|nmod|START_ENTITY changes|compound|END_ENTITY	Plasma prolactin changes following fenfluramine in depressed patients compared to controls : an evaluation of central serotonergic responsivity in depression .
8216698	0	fenfluramine	40,52	prolactin	16,25	fenfluramine	prolactin	MESH:D005277	102133150	Chemical	Gene	responders|xcomp|START_ENTITY responders|nsubj|Low Low|nmod|END_ENTITY	Low versus high prolactin responders to fenfluramine challenge : marker of behavioral differences in adult male cynomolgus macaques .
8570767	0	fenfluramine	85,97	prolactin	49,58	fenfluramine	prolactin	MESH:D005277	5617	Chemical	Gene	function|parataxis|START_ENTITY function|dobj|responses responses|compound|END_ENTITY	Serotonin function in detoxified heroin abusers : prolactin and cortisol responses to fenfluramine challenge .
3160963	0	fenfluramine	50,62	renin	73,78	fenfluramine	renin	MESH:D005277	24715(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activity activity|compound|END_ENTITY	Serotonin and norepinephrine-dependent effects of fenfluramine on plasma renin activity in conscious male rats .
11222873	0	fenitrothion	64,76	Androgen_receptor	0,17	fenitrothion	Androgen receptor	MESH:D005278	367	Chemical	Gene	antagonism|nmod|START_ENTITY antagonism|nsubj|END_ENTITY	Androgen_receptor antagonism by the organophosphate insecticide fenitrothion .
7926597	0	fenitrothion	50,62	cytochrome_P-450	27,43	fenitrothion	cytochrome P-450	MESH:D005278	4051	Chemical	Gene	administration|compound|START_ENTITY END_ENTITY|nmod|administration	Modification of testicular cytochrome_P-450 after fenitrothion administration .
22341868	0	fenofibrate	120,131	Apolipoprotein_B-48	0,19	fenofibrate	Apolipoprotein B-48	MESH:D011345	338	Chemical	Gene	treatment|amod|START_ENTITY effect|nmod|treatment END_ENTITY|dep|effect	Apolipoprotein_B-48 as a determinant of endothelial function in obese subjects with type_2_diabetes_mellitus : effect of fenofibrate treatment .
20729559	0	fenofibrate	81,92	Apolipoprotein_E	0,16	fenofibrate	Apolipoprotein E	MESH:D011345	348	Chemical	Gene	treatment|amod|START_ENTITY END_ENTITY|nmod|treatment	Apolipoprotein_E polymorphisms and postprandial triglyceridemia before and after fenofibrate treatment in the Genetics of Lipid Lowering and Diet Network -LRB- GOLDN -RRB- Study .
15554350	0	fenofibrate	14,25	C-reactive_protein	60,78	fenofibrate	C-reactive protein	MESH:D011345	1401	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|levels levels|nmod|END_ENTITY	The effect of fenofibrate on the levels of high sensitivity C-reactive_protein in dyslipidemic_obese patients .
15853856	0	fenofibrate	14,25	C-reactive_protein	60,78	fenofibrate	C-reactive protein	MESH:D011345	1401	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|levels levels|nmod|END_ENTITY	The effect of fenofibrate on the levels of high sensitivity C-reactive_protein in dyslipidaemic hypertensive patients .
16810076	0	fenofibrate	11,22	C-reactive_protein	26,44	fenofibrate	C-reactive protein	MESH:D011345	1401	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|amod|END_ENTITY	Effects of fenofibrate on C-reactive_protein levels in hypertriglyceridemic patients .
23603572	0	fenofibrate	14,25	CD40	51,55	fenofibrate	CD40	MESH:D011345	958	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|compound|END_ENTITY	PPARa agonist fenofibrate attenuates TNF-a-induced CD40 expression in 3T3-L1 adipocytes via the SIRT1-dependent signaling pathway .
24022598	0	fenofibrate	25,36	CD40	59,63	fenofibrate	CD40	MESH:D011345	958	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|compound|END_ENTITY	The protective effect of fenofibrate against TNF-a-induced CD40 expression through SIRT1-mediated deacetylation of NF-kB in endothelial cells .
22274300	0	fenofibrate	21,32	IL-8	84,88	fenofibrate	IL-8	MESH:D011345	3576	Chemical	Gene	effect|nmod|START_ENTITY effect|amod|END_ENTITY	Modulatory effect of fenofibrate on endothelial production of neutrophil chemokines IL-8 and ENA-78 .
22274300	12	fenofibrate	1458,1469	IL-8	1509,1513	fenofibrate	IL-8	MESH:D011345	3576	Chemical	Gene	reduced|nmod|START_ENTITY reduced|advcl|observed observed|nmod|production production|compound|END_ENTITY	ENA-78 protein and mRNA were significantly reduced by fenofibrate while no drug effects were observed on IL-8 production .
17245174	0	fenofibrate	129,140	Insulin	0,7	fenofibrate	Insulin	MESH:D011345	3630	Chemical	Gene	trial|nmod|START_ENTITY improved|nmod|trial improved|nsubjpass|sensitivity sensitivity|compound|END_ENTITY	Insulin sensitivity and mitochondrial function are improved in children with burn_injury during a randomized controlled trial of fenofibrate .
15971419	0	fenofibrate	37,48	NF-kappaB	14,23	fenofibrate	NF-kappaB	MESH:D011345	4790	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Inhibition of NF-kappaB signaling by fenofibrate , a peroxisome_proliferator-activated_receptor-alpha ligand , presents a therapeutic strategy for rheumatoid_arthritis .
26849944	0	fenofibrate	52,63	Nrf2	17,21	fenofibrate	Nrf2	MESH:D011345	18024(Tax:10090)	Chemical	Gene	protection|compound|START_ENTITY involved|nmod|protection involved|nsubjpass|Up-regulation Up-regulation|nmod|END_ENTITY	Up-regulation of Nrf2 is involved in FGF21-mediated fenofibrate protection against type 1 diabetic_nephropathy .
22859660	0	fenofibrate	11,22	PPAR-a	26,32	fenofibrate	PPAR-a	MESH:D011345	25747(Tax:10116)	Chemical	Gene	START_ENTITY|appos|ligand ligand|amod|END_ENTITY	Effects of fenofibrate , a PPAR-a ligand , on the haemodynamics of glycerol-induced renal_failure in rats .
16569247	0	fenofibrate	56,67	PPAR-alpha	36,46	fenofibrate	PPAR-alpha	MESH:D011345	19013(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|effects effects|nmod|END_ENTITY	In vitro and in vivo effects of the PPAR-alpha agonists fenofibrate and retinoic_acid in endometrial_cancer .
17343847	0	fenofibrate	51,62	PPAR_alpha	78,88	fenofibrate	PPAR alpha	MESH:D011345	25747(Tax:10116)	Chemical	Gene	activities|nmod|START_ENTITY activities|appos|agonist agonist|nmod|END_ENTITY	Antinociceptive and antiedematogenic activities of fenofibrate , an agonist of PPAR_alpha , and pioglitazone , an agonist of PPAR_gamma .
17610352	0	fenofibrate	91,102	PPAR_alpha	106,116	fenofibrate	PPAR alpha	MESH:D011345	25747(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Neurological recovery-promoting , anti-inflammatory , and anti-oxidative effects afforded by fenofibrate , a PPAR_alpha agonist , in traumatic brain_injury .
22547144	0	fenofibrate	113,124	PPAR_alpha	4,14	fenofibrate	PPAR alpha	MESH:D011345	5465	Chemical	Gene	associated|xcomp|START_ENTITY associated|nsubjpass|gene gene|compound|END_ENTITY	The PPAR_alpha gene is associated with triglyceride , low-density cholesterol and inflammation marker response to fenofibrate intervention : the GOLDN study .
17343847	0	fenofibrate	51,62	PPAR_gamma	122,132	fenofibrate	PPAR gamma	MESH:D011345	25664(Tax:10116)	Chemical	Gene	activities|nmod|START_ENTITY activities|appos|agonist agonist|nmod|END_ENTITY	Antinociceptive and antiedematogenic activities of fenofibrate , an agonist of PPAR_alpha , and pioglitazone , an agonist of PPAR_gamma .
22100307	2	fenofibrate	296,307	PPARa	282,287	fenofibrate	PPARa	MESH:D011345	5465	Chemical	Gene	START_ENTITY|nsubj|agonist agonist|compound|END_ENTITY	Here , we demonstrate that the PPARa agonist fenofibrate activated expression of the glucose transporter Glut4 .
24899625	0	fenofibrate	92,103	PPARa	34,39	fenofibrate	VLDLR	MESH:D011345	22359(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY required|nmod|effect required|nsubjpass|Upregulation Upregulation|nmod|VLDLR VLDLR|nmod|END_ENTITY	Upregulation of hepatic VLDLR via PPARa is required for the triglyceride-lowering effect of fenofibrate .
12369742	0	fenofibrate	85,96	PPARalpha	65,74	fenofibrate	PPARalpha	MESH:D011345	25747(Tax:10116)	Chemical	Gene	effect|amod|START_ENTITY effect|nmod|receptors receptors|appos|END_ENTITY	The effect of peroxisome proliferator-activated receptors alpha -LRB- PPARalpha -RRB- agonist , fenofibrate , on lipid peroxidation , total antioxidant capacity , and plasma paraoxonase_1 -LRB- PON_1 -RRB- activity .
17204199	0	fenofibrate	20,31	PPARalpha	1,10	fenofibrate	PPARalpha	MESH:D011345	5465	Chemical	Gene	inhibits|nsubj|START_ENTITY agonist|parataxis|inhibits agonist|nsubj|END_ENTITY	-LSB- PPARalpha agonist -- fenofibrate inhibits LPS-induced tissue factor expression in THP-1 cells -RSB- .
18754816	0	fenofibrate	46,57	PPARalpha	26,35	fenofibrate	PPARalpha	MESH:D011345	25747(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|activator activator|compound|END_ENTITY	Effects and mechanisms of PPARalpha activator fenofibrate on myocardial_remodelling in hypertension .
12867511	0	fenofibrate	124,135	Peroxisome_proliferator-activated_receptor-alpha	0,48	fenofibrate	Peroxisome proliferator-activated receptor-alpha	MESH:D011345	19013(Tax:10090)	Chemical	Gene	treatment|compound|START_ENTITY induced|nmod|treatment induced|nsubj|activation activation|amod|END_ENTITY	Peroxisome_proliferator-activated_receptor-alpha activation as a mechanism of preventive neuroprotection induced by chronic fenofibrate treatment .
21468610	0	fenofibrate	11,22	Semaphorin_6B	26,39	fenofibrate	Semaphorin 6B	MESH:D011345	84609(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|amod|END_ENTITY	Effects of fenofibrate on Semaphorin_6B gene expression in rat skeletal muscle .
23529238	0	fenofibrate	42,53	TRB3	9,13	fenofibrate	TRB3	MESH:D011345	246273(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nmod|effect	-LSB- Role of TRB3 in the inhibitory effect of fenofibrate against high glucose-induced proliferation of glomerular mesangial cells -RSB- .
18159007	0	fenofibrate	11,22	VCAM-1	45,51	fenofibrate	VCAM-1	MESH:D011345	25361(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	-LSB- Impact of fenofibrate on NO and endothelial VCAM-1 expression in hyperlipidemic rats -RSB- .
24573924	0	fenofibrate	85,96	VCAM-1	40,46	fenofibrate	VCAM-1	MESH:D011345	25361(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of hyperlipidemia on endothelial VCAM-1 expression and the protective role of fenofibrate .
19023279	0	fenofibrate	10,21	adiponectin	25,36	fenofibrate	adiponectin	MESH:D011345	9370	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|biomarkers biomarkers|amod|END_ENTITY	Effect of fenofibrate on adiponectin and inflammatory biomarkers in metabolic_syndrome patients .
23149075	0	fenofibrate	72,83	adiponectin	48,59	fenofibrate	adiponectin	MESH:D011345	9370	Chemical	Gene	evidence|acl|START_ENTITY evidence|nmod|determinants determinants|nmod|response response|compound|END_ENTITY	Preliminary evidence of genetic determinants of adiponectin response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network .
22930812	0	fenofibrate	10,21	apoE	47,51	fenofibrate	apoE	MESH:D011345	348	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of fenofibrate and atorvastatin on VLDL apoE metabolism in men with the metabolic_syndrome .
2731478	0	fenofibrate	11,22	fibrinogen	26,36	fenofibrate	fibrinogen	MESH:D011345	2244	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|concentration concentration|amod|END_ENTITY	-LSB- Effect of fenofibrate on fibrinogen concentration and blood viscosity .
1739751	0	fenofibrate	66,77	hepatic_lipase	19,33	fenofibrate	hepatic lipase	MESH:D011345	24538(Tax:10116)	Chemical	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|nmod|expression expression|amod|END_ENTITY	Down-regulation of hepatic_lipase gene expression and activity by fenofibrate .
15124979	0	fenofibrate	22,33	insulin	37,44	fenofibrate	insulin	MESH:D011345	3630	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	Effects of micronized fenofibrate on insulin resistance in patients with metabolic_syndrome .
24560135	0	fenofibrate	61,72	insulin	90,97	fenofibrate	insulin	MESH:D011345	3630	Chemical	Gene	has|nsubj|START_ENTITY has|dobj|effect effect|nmod|sensitivity sensitivity|compound|END_ENTITY	The peroxisome_proliferator-activated_receptor_alpha agonist fenofibrate has no effect on insulin sensitivity compared to atorvastatin in type_2_diabetes_mellitus ; a randomised , double-blind controlled trial .
14707891	0	fenofibrate	25,36	paraoxonase	40,51	fenofibrate	paraoxonase	MESH:D011345	5444	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	The effect of micronised fenofibrate on paraoxonase activity in patients with coronary_heart_disease .
15971419	0	fenofibrate	37,48	peroxisome_proliferator-activated_receptor-alpha	52,100	fenofibrate	peroxisome proliferator-activated receptor-alpha	MESH:D011345	5465	Chemical	Gene	START_ENTITY|appos|ligand ligand|amod|END_ENTITY	Inhibition of NF-kappaB signaling by fenofibrate , a peroxisome_proliferator-activated_receptor-alpha ligand , presents a therapeutic strategy for rheumatoid_arthritis .
18096152	0	fenofibrate	136,147	peroxisome_proliferator-activated_receptor-alpha	79,127	fenofibrate	peroxisome proliferator-activated receptor-alpha	MESH:D011345	19013(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Suppression Suppression|nmod|airway_inflammation airway_inflammation|nmod|agonist agonist|amod|END_ENTITY	Suppression of allergen-induced airway_inflammation and immune response by the peroxisome_proliferator-activated_receptor-alpha agonist fenofibrate .
12042669	0	fenofibrate	133,144	peroxisome_proliferator-activated_receptor_alpha	28,76	fenofibrate	peroxisome proliferator-activated receptor alpha	MESH:D011345	5465	Chemical	Gene	ability|nmod|START_ENTITY mutations|nmod|ability mutations|compound|END_ENTITY	Effect of apolipoprotein_E , peroxisome_proliferator-activated_receptor_alpha and lipoprotein_lipase gene mutations on the ability of fenofibrate to improve lipid profiles and reach clinical guideline targets among hypertriglyceridemic patients .
12377786	0	fenofibrate	93,104	peroxisome_proliferator-activated_receptor_alpha	36,84	fenofibrate	peroxisome proliferator-activated receptor alpha	MESH:D011345	19013(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Reduction Reduction|nmod|atherosclerosis atherosclerosis|nmod|agonist agonist|amod|END_ENTITY	Reduction of atherosclerosis by the peroxisome_proliferator-activated_receptor_alpha agonist fenofibrate in mice .
17356236	0	fenofibrate	66,77	peroxisome_proliferator-activated_receptor_alpha	10,58	fenofibrate	peroxisome proliferator-activated receptor alpha	MESH:D011345	5465	Chemical	Gene	channels|amod|START_ENTITY ligand|dobj|channels ligand|nsubj|Effect Effect|nmod|END_ENTITY	Effect of peroxisome_proliferator-activated_receptor_alpha ligand fenofibrate on K -LRB- v -RRB- channels in the insulin-secreting cell line HIT-T15 .
23620259	0	fenofibrate	98,109	peroxisome_proliferator-activated_receptor_alpha	41,89	fenofibrate	peroxisome proliferator-activated receptor alpha	MESH:D011345	5465	Chemical	Gene	START_ENTITY|nsubj|Treatment Treatment|nmod|erosive_osteoarthritis erosive_osteoarthritis|nmod|agonist agonist|amod|END_ENTITY	Treatment of erosive_osteoarthritis with peroxisome_proliferator-activated_receptor_alpha agonist fenofibrate : a pilot study .
16850744	0	fenofibrate	22,33	plasminogen_activator_inhibitor-1	37,70	fenofibrate	plasminogen activator inhibitor-1	MESH:D011345	5054	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|amod|END_ENTITY	Inhibitory effects of fenofibrate on plasminogen_activator_inhibitor-1 expression in human endothelial cells .
19618719	0	fenofibrate	22,33	toll-like_receptor_4	60,80	fenofibrate	toll-like receptor 4	MESH:D011345	21898(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Inhibitory effect of fenofibrate on angiotensin_II-induced toll-like_receptor_4 expression , myeloperoxidase activity and expression in RAW264 .7 cells -RSB- .
12556736	0	fenoldopam	37,47	DA1	16,19	fenoldopam	DA1	MESH:D018818	28495	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|agonist agonist|compound|END_ENTITY	The role of the DA1 receptor agonist fenoldopam in the management of critically ill , transplant , and hypertensive patients .
1352429	0	fenoldopam	31,41	DA1	9,12	fenoldopam	DA1	MESH:D018818	294269(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	Dopamine DA1 receptor agonist , fenoldopam , reverses glycine-induced hyperfiltration in rats .
1671029	0	fenoldopam	40,50	DA1	19,22	fenoldopam	DA1	MESH:D018818	28495	Chemical	Gene	stimulation|nmod|START_ENTITY stimulation|compound|END_ENTITY	Selective dopamine DA1 stimulation with fenoldopam in cirrhotic patients with ascites : a systemic , splanchnic and renal hemodynamic study .
2868748	0	fenoldopam	13,23	DA1	45,48	fenoldopam	DA1	MESH:D018818	28495	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Studies with fenoldopam , a dopamine receptor DA1 agonist , in essential hypertension .
2899970	0	fenoldopam	87,97	DA1	65,68	fenoldopam	DA1	MESH:D018818	28495	Chemical	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	Hemodynamic , renal , and neurohumoral effects of a selective oral DA1 receptor agonist -LRB- fenoldopam -RRB- in patients with congestive_heart_failure .
2574081	0	fenoldopam	10,20	dopamine_D-1_receptor	24,45	fenoldopam	dopamine D-1 receptor	MESH:D018818	1812	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Effect of fenoldopam , a dopamine_D-1_receptor agonist , on pituitary , gonadal and thyroid hormone secretion .
21714857	0	fenoldopam	10,20	neutrophil_gelatinase-associated_lipocaline	43,86	fenoldopam	neutrophil gelatinase-associated lipocaline	MESH:D018818	3934	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	High-dose fenoldopam reduces postoperative neutrophil_gelatinase-associated_lipocaline and cystatin_C levels in pediatric cardiac surgery .
2575038	0	fenoldopam	11,21	prolactin	60,69	fenoldopam	prolactin	MESH:D018818	24683(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of fenoldopam on alpha-methyl-p-tyrosine-stimulated prolactin secretion in conscious rats .
3085356	0	fenoterol	40,49	beta-2	14,20	fenoterol	beta-2	MESH:D005280	10242	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|agonist agonist|amod|END_ENTITY	Effect of the beta-2 adrenergic agonist fenoterol on the release of leukotrienes and prostaglandin_D2 from human lung parenchyma .
9734347	0	fenoterol	110,119	beta2-adrenoceptor	123,141	fenoterol	beta2-adrenoceptor	MESH:D005280	154	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Downregulation of the expression of intercellular_adhesion_molecule _ -LRB- ICAM -RRB- -1 on bronchial epithelial cells by fenoterol , a beta2-adrenoceptor agonist .
1493852	0	fenoterol	56,65	beta_2-adrenoceptor	28,47	fenoterol	beta 2-adrenoceptor	MESH:D005280	154	Chemical	Gene	START_ENTITY|nsubj|pharmacokinetics pharmacokinetics|nmod|agonist agonist|amod|END_ENTITY	The pharmacokinetics of the beta_2-adrenoceptor agonist fenoterol in healthy women .
3974172	0	fenoterol	44,53	beta_2-adrenoceptor	15,34	fenoterol	beta 2-adrenoceptor	MESH:D005280	154	Chemical	Gene	agonists|amod|START_ENTITY agonists|amod|END_ENTITY	Effects of the beta_2-adrenoceptor agonists fenoterol and salbutamol on force of contraction in isolated human ventricular myocardium .
8777955	0	fenoterol	91,100	beta_2-adrenoceptor	62,81	fenoterol	beta 2-adrenoceptor	MESH:D005280	154	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Role of cyclic_AMP in the modulation of IgE production by the beta_2-adrenoceptor agonist , fenoterol .
6559719	0	fenoterol	14,23	oxytocin	63,71	fenoterol	oxytocin	MESH:D005280	5020	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	-LSB- Influence of fenoterol , ritodrine and clenbuterol on maternal oxytocin and PGFM levels -RSB- .
24267695	0	fenoxaprop-P-ethyl	72,90	cytochrome_P450_monooxygenase	12,41	fenoxaprop-P-ethyl	cytochrome P450 monooxygenase	null	57404	Chemical	Gene	role|acl|START_ENTITY role|nmod|END_ENTITY	The role of cytochrome_P450_monooxygenase in the different responses to fenoxaprop-P-ethyl in annual bluegrass -LRB- Poa annua L. -RRB- and short awned foxtail -LRB- Alopecurus aequalis Sobol . -RRB- .
22015243	0	fenpropimorph	10,23	T-2	81,84	fenpropimorph	T-2	MESH:C050435	292	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of fenpropimorph , prochloraz and tebuconazole on growth and production of T-2 and HT-2_toxins by Fusarium langsethiae in oat-based medium .
22832793	0	fenproporex	123,134	acetylcholinesterase	14,34	fenproporex	acetylcholinesterase	MESH:C026013	83817(Tax:10116)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activity activity|amod|END_ENTITY	Inhibition of acetylcholinesterase activity in brain and behavioral analysis in adult rats after chronic administration of fenproporex .
26247155	0	fenproporex	24,35	acetylcholinesterase	46,66	fenproporex	acetylcholinesterase	MESH:C026013	83817(Tax:10116)	Chemical	Gene	administration|nmod|START_ENTITY increased|nsubj|administration increased|dobj|activity activity|amod|END_ENTITY	Acute administration of fenproporex increased acetylcholinesterase activity in brain of young rats .
9626341	0	fenretinide	10,21	IGF-I	32,37	fenretinide	IGF-I	MESH:D017313	3479	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of fenretinide on plasma IGF-I and IGFBP-3 in early breast_cancer patients .
21223952	0	fentanyl	50,58	CYP3A4	10,16	fentanyl	CYP3A4	MESH:D005283	1576	Chemical	Gene	Impact|nmod|START_ENTITY Impact|nmod|END_ENTITY	Impact of CYP3A4 * 1G polymorphism on metabolism of fentanyl in Chinese patients undergoing lower abdominal surgery .
2923932	0	fentanyl	22,30	Prolactin	0,9	fentanyl	Prolactin	MESH:D005283	5617	Chemical	Gene	START_ENTITY|nsubj|response response|compound|END_ENTITY	Prolactin response to fentanyl in depression .
12013149	0	fentanyl	10,18	TNF-alpha	22,31	fentanyl	TNF-alpha	MESH:D005283	24835(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|amod|END_ENTITY	Effect of fentanyl on TNF-alpha and IL-1beta levels during global ischemia/reperfusion in rats .
9755082	0	fentanyl	10,18	TNF-alpha	106,115	fentanyl	TNF-alpha	MESH:D005283	24835(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|rats rats|acl|receiving receiving|dobj|injection injection|nmod|END_ENTITY	Effect of fentanyl on morphine levels in the brain in rats receiving intracerebroventricular injection of TNF-alpha .
11698319	0	fentanyl	34,42	c-Fos	82,87	fentanyl	c-Fos	MESH:D005283	314322(Tax:10116)	Chemical	Gene	pre-administration|nmod|START_ENTITY suppresses|nsubj|pre-administration suppresses|ccomp|evoked evoked|dobj|expression expression|amod|END_ENTITY	Intrathecal pre-administration of fentanyl effectively suppresses formalin evoked c-Fos expression in spinal cord of rat .
10467925	0	fentanyl	14,22	c-fos	26,31	fentanyl	c-fos	MESH:D005283	2353	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	The effect of fentanyl on c-fos expression in the trigeminal brainstem complex produced by pulpal heat stimulation in the ferret .
1965314	0	fentanyl	41,49	growth_hormone	4,18	fentanyl	growth hormone	MESH:D005283	81668(Tax:10116)	Chemical	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	The growth_hormone secretory response to fentanyl in rat : an involvement of mu type receptors .
2554192	0	fentanyl	60,68	growth_hormone	93,107	fentanyl	growth hormone	MESH:D005283	2688	Chemical	Gene	Investigations|nmod|START_ENTITY Investigations|dep|END_ENTITY	Investigations with the specific mu-opiate_receptor agonist fentanyl in depressive patients : growth_hormone , prolactin , cortisol , noradrenaline and euphoric responses .
14764338	0	fentanyl	45,53	prolactin	12,21	fentanyl	prolactin	MESH:D005283	5617	Chemical	Gene	anaesthesia|amod|START_ENTITY related|nmod|anaesthesia related|dobj|secretion secretion|compound|END_ENTITY	Age related prolactin secretion in men after fentanyl anaesthesia .
6099509	0	fentanyl	28,36	prolactin	40,49	fentanyl	prolactin	MESH:D005283	5617	Chemical	Gene	influence|nmod|START_ENTITY influence|nmod|END_ENTITY	Dose-dependent influence of fentanyl on prolactin , growth_hormone , and mood .
2943380	0	fentanyl	63,71	vasopressin	24,35	fentanyl	vasopressin	MESH:D005283	551	Chemical	Gene	responses|nmod|START_ENTITY responses|compound|END_ENTITY	Haemodynamic and plasma vasopressin responses during high-dose fentanyl or sufentanil anaesthesia .
3116201	0	fentanyl	11,19	vasopressin	23,34	fentanyl	vasopressin	MESH:D005283	551	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of fentanyl on vasopressin secretion in human subjects .
6128067	0	fentanyl	61,69	vasopressin	24,35	fentanyl	vasopressin	MESH:D005283	551	Chemical	Gene	anaesthesia|amod|START_ENTITY responses|nmod|anaesthesia responses|compound|END_ENTITY	Haemodynamic and plasma vasopressin responses with high-dose fentanyl anaesthesia during aorto-coronary bypass operations .
6869858	0	fentanyl	22,30	vasopressin	69,80	fentanyl	vasopressin	MESH:D005283	551	Chemical	Gene	START_ENTITY|nmod|elevation elevation|nmod|END_ENTITY	Influence of epidural fentanyl on stress-induced elevation of plasma vasopressin -LRB- ADH -RRB- after surgery .
17484068	0	fenvalerate	69,80	P450	53,57	fenvalerate	P450	MESH:C017690	1555	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Identification of the proteins related to cytochrome P450 induced by fenvalerate in a Trichoplusia ni cell line .
8340253	0	ferric	98,104	Transforming_growth_factor-alpha	0,32	ferric	Transforming growth factor-alpha	null	24827(Tax:10116)	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|expression expression|amod|END_ENTITY	Transforming_growth_factor-alpha expression of renal proximal tubules in Wistar_rats treated with ferric and aluminum_nitrilotriacetate .
18785585	0	ferric_chelate	125,139	FRO1	156,160	ferric chelate	FRO1	null	543871(Tax:4081)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Use of the modified viral satellite DNA vector to silence mineral nutrition-related genes in plants : silencing of the tomato ferric_chelate reductase gene , FRO1 , as an example .
23082924	0	ferric_chloride	63,78	BACE1	46,51	ferric chloride	BACE1	MESH:C024555	29392(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Timosaponin-BII inhibits the up-regulation of BACE1 induced by ferric_chloride in rat retina .
17089354	0	ferricyanide	20,32	myoglobin	41,50	ferricyanide	myoglobin	MESH:C007931	4151	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Catalytic effect of ferricyanide between myoglobin and luminol and effect of temperature .
2002036	0	ferricyanide	49,61	sulfite_oxidase	30,45	ferricyanide	sulfite oxidase	MESH:C007931	81805(Tax:10116)	Chemical	Gene	Oxidation|nmod|START_ENTITY Oxidation|nmod|END_ENTITY	Oxidation of molybdopterin in sulfite_oxidase by ferricyanide .
19092216	0	ferrihydrite	28,40	Cd2	9,12	ferrihydrite	Cd2	MESH:C092844	914	Chemical	Gene	+|nmod|START_ENTITY +|nsubj|END_ENTITY	Modeling Cd2 + sorption onto ferrihydrite in the presence of phthalic_acid .
15611868	0	ferrioxamine_B	51,65	Arn3p	21,26	ferrioxamine B	Arn3p	MESH:C002577	856644(Tax:4932)	Chemical	Gene	uptake|compound|START_ENTITY END_ENTITY|dobj|uptake	Sed1p interacts with Arn3p physically and mediates ferrioxamine_B uptake in Saccharomyces_cerevisiae .
8600980	0	ferritin	99,107	cytochrome_P-450	8,24	ferritin	cytochrome P-450	null	25251(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of cytochrome_P-450 in the stimulation of microsomal production of reactive oxygen species by ferritin .
1519605	0	ferritin	41,49	erythropoietin	103,117	ferritin	erythropoietin	null	2056	Chemical	Gene	START_ENTITY|nmod|therapy therapy|compound|END_ENTITY	Assessment of iron status by erythrocyte ferritin in uremic patients with or without recombinant human erythropoietin therapy .
26618110	0	ferritin	45,53	insulin	15,22	ferritin	insulin	null	3630	Chemical	Gene	resistance|nmod|START_ENTITY resistance|compound|END_ENTITY	Association of insulin resistance with serum ferritin and aminotransferases-iron hypothesis .
24264112	0	ferritin	52,60	transferrin	37,48	ferritin	transferrin	null	7018	Chemical	Gene	synthesis|compound|START_ENTITY END_ENTITY|nmod|synthesis	Effects of iron transferrin and zinc transferrin on ferritin synthesis by human lymphocytes .
2536083	0	ferritin	104,112	transferrin	89,100	ferritin	transferrin	null	7018	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of phosphate-containing compounds in the transfer of indium-111 and gallium-67 from transferrin to ferritin .
2852009	0	ferritin	47,55	transferrin	59,70	ferritin	transferrin	null	7018	Chemical	Gene	transfer|nmod|START_ENTITY transfer|nmod|END_ENTITY	The superoxide-dependent transfer of iron from ferritin to transferrin and lactoferrin .
19057765	0	ferrocenes	25,35	apo-ferritin	62,74	ferrocenes	apo-ferritin	CHEBI:51005	2495	Chemical	Gene	insertion|nmod|START_ENTITY insertion|nmod|END_ENTITY	Noncovalent insertion of ferrocenes into the protein shell of apo-ferritin .
221465	0	ferrous	29,36	cytochrome_c	15,27	ferrous	cytochrome c	null	54205	Chemical	Gene	START_ENTITY|nsubj|Interaction Interaction|nmod|END_ENTITY	Interaction of cytochrome_c , ferrous ion , and phosphate .
14637135	0	ferrous	21,28	myeloperoxidase	29,44	ferrous	myeloperoxidase	null	4353	Chemical	Gene	conversion|nmod|START_ENTITY END_ENTITY|nsubj|conversion	Direct conversion of ferrous myeloperoxidase to compound II by hydrogen_peroxide : an anaerobic stopped-flow study .
16220782	0	ferulic_acid	11,23	E-selectin	27,37	ferulic acid	E-selectin	MESH:C004999	6401	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effects of ferulic_acid on E-selectin expression in activated endothelial cell and leukocyte-endothelial cell adhesion .
23075678	0	ferulic_acid	22,34	amyloid_precursor_protein	38,63	ferulic acid	amyloid precursor protein	MESH:C004999	11820(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Protective effects of ferulic_acid in amyloid_precursor_protein plus presenilin-1 transgenic mouse model of Alzheimer_disease .
9112332	0	ferulic_acid	21,33	macrophage_inflammatory_protein-2	37,70	ferulic acid	macrophage inflammatory protein-2	MESH:C004999	20310(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Inhibitory effect of ferulic_acid on macrophage_inflammatory_protein-2 production in a murine macrophage cell line , RAW264 .7 .
24060056	0	ferulic_acid	23,35	nuclear_factor-kappaB	71,92	ferulic acid	nuclear factor-kappaB	MESH:C004999	81736(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY mediated|nsubj|effect mediated|nmod|END_ENTITY	Ameliorative effect of ferulic_acid against renal_injuries mediated by nuclear_factor-kappaB during glycerol-induced nephrotoxicity in Wistar_rats .
11025439	0	fetuin	52,58	TGF-beta	74,82	fetuin	TGF-beta	null	7040	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Regulation of human monocyte proMMP-9 production by fetuin , an endogenous TGF-beta antagonist .
11994059	0	fexofenadine	72,84	P-glycoprotein	47,61	fexofenadine	P-glycoprotein	MESH:C093230	5243	Chemical	Gene	START_ENTITY|nsubj|polymorphisms polymorphisms|nmod|substrate substrate|amod|END_ENTITY	MDR1 gene polymorphisms and disposition of the P-glycoprotein substrate fexofenadine .
15821041	0	fexofenadine	51,63	P-glycoprotein	0,14	fexofenadine	P-glycoprotein	MESH:C093230	67078(Tax:10090)	Chemical	Gene	efflux|nmod|START_ENTITY role|nmod|efflux plays|dobj|role plays|nsubj|END_ENTITY	P-glycoprotein plays a major role in the efflux of fexofenadine in the small intestine and blood-brain barrier , but only a limited role in its biliary excretion .
18299336	0	fexofenadine	73,85	P-glycoprotein	26,40	fexofenadine	P-glycoprotein	MESH:C093230	610926(Tax:9615)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Modest effect of impaired P-glycoprotein on the plasma concentrations of fexofenadine , quinidine , and loperamide following oral administration in collies .
19114463	0	fexofenadine	90,102	P-glycoprotein	69,83	fexofenadine	P-glycoprotein	MESH:C093230	67078(Tax:10090)	Chemical	Gene	administration|amod|START_ENTITY END_ENTITY|nmod|administration	Fexofenadine brain exposure and the influence of blood-brain barrier P-glycoprotein after fexofenadine and terfenadine administration .
19221726	0	fexofenadine	58,70	P-glycoprotein	87,101	fexofenadine	P-glycoprotein	MESH:C093230	5243	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY quercetin|nmod|pharmacokinetics effect|nmod|quercetin effect|appos|substrate substrate|nmod|END_ENTITY	Short-term effect of quercetin on the pharmacokinetics of fexofenadine , a substrate of P-glycoprotein , in healthy volunteers .
19552748	0	fexofenadine	32,44	P-glycoprotein	54,68	fexofenadine	P-glycoprotein	MESH:C093230	5243	Chemical	Gene	disposition|nmod|START_ENTITY disposition|nmod|verapamil verapamil|amod|END_ENTITY	Enantioselective disposition of fexofenadine with the P-glycoprotein inhibitor verapamil .
20306185	0	fexofenadine	51,63	P-glycoprotein	67,81	fexofenadine	P-glycoprotein	MESH:C093230	5243	Chemical	Gene	START_ENTITY|appos|substrate substrate|amod|END_ENTITY	Effect of metronidazole on the pharmacokinetics of fexofenadine , a P-glycoprotein substrate , in healthy male volunteers .
26922536	0	fexofenadine	49,61	P-glycoprotein	86,100	fexofenadine	P-glycoprotein	MESH:C093230	287115(Tax:10116)	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY resveratrol|nmod|pharmacokinetics Effect|nmod|resveratrol Effect|dep|Involvement Involvement|nmod|inhibition inhibition|amod|END_ENTITY	Effect of resveratrol on the pharmacokinetics of fexofenadine in rats : Involvement of P-glycoprotein inhibition .
16270723	0	fexofenadine	14,26	intercellular_adhesion_molecule_1	44,77	fexofenadine	intercellular adhesion molecule 1	MESH:C093230	3383	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|nmod|END_ENTITY	The effect of fexofenadine on expression of intercellular_adhesion_molecule_1 and induction of apoptosis on peripheral eosinophils .
26467209	0	fexofenadine	142,154	p-glycoprotein	41,55	fexofenadine	p-glycoprotein	MESH:C093230	5243	Chemical	Gene	losartan|dep|START_ENTITY using|xcomp|losartan assessment|acl|using strategy|dep|assessment using|dobj|strategy substrate|xcomp|using substrate|nsubj|Prediction Prediction|nmod|area area|nmod|curve curve|nmod|END_ENTITY	Prediction of area under the curve for a p-glycoprotein , a CYP3A4 and a CYP2C9 substrate using a single time point strategy : assessment using fexofenadine , itraconazole and losartan and metabolites .
22767515	0	filopodium	19,29	LIN7	0,4	filopodium	LIN7	null	8825	Chemical	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	LIN7 regulates the filopodium - and neurite-promoting activity of IRSp53 .
1283117	0	finasteride	25,36	5_alpha-reductase	40,57	finasteride	5 alpha-reductase	MESH:D018120	6715	Chemical	Gene	treatment|nmod|START_ENTITY treatment|appos|inhibitor inhibitor|amod|END_ENTITY	Prolonged treatment with finasteride -LRB- a 5_alpha-reductase inhibitor -RRB- does not affect bone density and metabolism .
1309834	0	finasteride	46,57	5_alpha-reductase	69,86	finasteride	5 alpha-reductase	MESH:D018120	6715	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Hair growth effects of oral administration of finasteride , a steroid 5_alpha-reductase inhibitor , alone and in combination with topical minoxidil in the balding stumptail macaque .
1322427	0	finasteride	10,21	5_alpha-reductase	25,42	finasteride	5 alpha-reductase	MESH:D018120	6715	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effect of finasteride , a 5_alpha-reductase inhibitor , on serum gonadotropins in normal men .
1373779	0	finasteride	55,66	5_alpha-reductase	26,43	finasteride	5 alpha-reductase	MESH:D018120	6715	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	The clinical effects of a 5_alpha-reductase inhibitor , finasteride , on benign_prostatic_hyperplasia .
1699965	0	finasteride	10,21	5_alpha-reductase	25,42	finasteride	5 alpha-reductase	MESH:D018120	6715	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|inhibitor inhibitor|amod|END_ENTITY	Effect of finasteride , a 5_alpha-reductase inhibitor on prostate tissue androgens and prostate-specific_antigen .
1701660	0	finasteride	59,70	5_alpha-reductase	30,47	finasteride	5 alpha-reductase	MESH:D018120	6715	Chemical	Gene	START_ENTITY|nsubj|development development|nmod|inhibitor inhibitor|amod|END_ENTITY	The clinical development of a 5_alpha-reductase inhibitor , finasteride .
1722168	0	finasteride	51,62	5_alpha-reductase	22,39	finasteride	5 alpha-reductase	MESH:D018120	6715	Chemical	Gene	effects|appos|START_ENTITY effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Hormonal effects of a 5_alpha-reductase inhibitor -LRB- finasteride -RRB- on hormonal levels in normal men and in patients with benign_prostatic_hyperplasia .
7479205	0	finasteride	28,39	5_alpha-reductase	43,60	finasteride	5 alpha-reductase	MESH:D018120	6715	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Pharmacodynamic modeling of finasteride , a 5_alpha-reductase inhibitor .
7535480	0	finasteride	32,43	5_alpha-reductase	0,17	finasteride	5 alpha-reductase	MESH:D018120	6715	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	5_alpha-reductase inhibition by finasteride -LRB- Proscar -RRB- in epithelium and stroma of human benign_prostatic_hyperplasia .
7615107	0	finasteride	34,45	5_alpha-reductase	49,66	finasteride	5 alpha-reductase	MESH:D018120	6715	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Clinical and endocrine effects of finasteride , a 5_alpha-reductase inhibitor , in women with idiopathic hirsutism .
7962284	0	finasteride	65,76	5_alpha-reductase	37,54	finasteride	5 alpha-reductase	MESH:D018120	6715	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Clinical and hormonal effects of the 5_alpha-reductase inhibitor finasteride in idiopathic hirsutism .
8077349	0	finasteride	14,25	5_alpha-reductase	29,46	finasteride	5 alpha-reductase	MESH:D018120	6715	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	The effect of finasteride , a 5_alpha-reductase inhibitor , on scalp skin testosterone and dihydrotestosterone concentrations in patients with male pattern baldness .
8077369	0	finasteride	11,22	5_alpha-reductase	26,43	finasteride	5 alpha-reductase	MESH:D018120	6715	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|inhibitor inhibitor|amod|END_ENTITY	Effects of finasteride , a 5_alpha-reductase inhibitor , on circulating androgens and gonadotropin secretion in hirsute women .
8693970	0	finasteride	38,49	5_alpha-reductase	76,93	finasteride	5 alpha-reductase	MESH:D018120	6715	Chemical	Gene	administration|nmod|START_ENTITY Effect|nmod|administration Effect|appos|inhibitor inhibitor|nmod|END_ENTITY	Effect of long-term administration of finasteride -LRB- MK-906 -RRB- , an inhibitor of 5_alpha-reductase , in patients with benign_prostatic_hyperplasia .
8747081	0	finasteride	124,135	5_alpha-reductase	0,17	finasteride	5 alpha-reductase	MESH:D018120	6715	Chemical	Gene	effect|nmod|START_ENTITY activity|dep|effect activity|amod|END_ENTITY	5_alpha-reductase activity in cultured epithelial and stromal cells from normal and hyperplastic human prostates -- effect of finasteride -LRB- Proscar -RRB- , a 5_alpha-reductase inhibitor .
8747081	0	finasteride	124,135	5_alpha-reductase	149,166	finasteride	5 alpha-reductase	MESH:D018120	6715	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	5_alpha-reductase activity in cultured epithelial and stromal cells from normal and hyperplastic human prostates -- effect of finasteride -LRB- Proscar -RRB- , a 5_alpha-reductase inhibitor .
8768856	0	finasteride	95,106	5_alpha-reductase	46,63	finasteride	5 alpha-reductase	MESH:D018120	6715	Chemical	Gene	combination|nmod|START_ENTITY Effect|appos|combination Effect|amod|END_ENTITY	Effect of MK-386 , a novel inhibitor of type 1 5_alpha-reductase , alone and in combination with finasteride , on serum dihydrotestosterone concentrations in men .
9154506	0	finasteride	42,53	5_alpha-reductase	13,30	finasteride	5 alpha-reductase	MESH:D018120	6715	Chemical	Gene	Effects|appos|START_ENTITY Effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Effects of a 5_alpha-reductase inhibitor , finasteride , on the developing prostate and testis of a marsupial .
9589555	0	finasteride	43,54	5_alpha-reductase	15,32	finasteride	5 alpha-reductase	MESH:D018120	6715	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Effects of the 5_alpha-reductase inhibitor finasteride on serum levels of gonadal , adrenal , and hypophyseal hormones and its clinical significance : a prospective clinical study .
10037433	0	finasteride	15,26	5alpha-reductase	54,70	finasteride	5alpha-reductase	MESH:D018120	6715	Chemical	Gene	Selectivity|nmod|START_ENTITY Selectivity|nmod|inhibitor inhibitor|nmod|activity activity|amod|END_ENTITY	Selectivity of finasteride as an in vivo inhibitor of 5alpha-reductase isozyme enzymatic activity in the human prostate .
11204259	0	finasteride	61,72	5alpha-reductase	30,46	finasteride	5alpha-reductase	MESH:D018120	6715	Chemical	Gene	therapy|amod|START_ENTITY type|nmod|therapy type|amod|END_ENTITY	Prostatic expression of human 5alpha-reductase type 2 during finasteride therapy : a randomized , double-blind , placebo-controlled study .
12031682	0	finasteride	134,145	5alpha-reductase	35,51	finasteride	5alpha-reductase	MESH:D018120	6715	Chemical	Gene	inhibition|nmod|START_ENTITY sensitivity|acl|inhibition study|dep|sensitivity study|nmod|isoforms isoforms|amod|END_ENTITY	Comparative study of human steroid 5alpha-reductase isoforms in prostate and female breast skin tissues : sensitivity to inhibition by finasteride and epristeride .
16834758	0	finasteride	45,56	5alpha-reductase	18,34	finasteride	5alpha-reductase	MESH:D018120	6715	Chemical	Gene	START_ENTITY|nsubj|look look|nmod|inhibitor inhibitor|amod|END_ENTITY	A new look at the 5alpha-reductase inhibitor finasteride .
20460827	0	finasteride	21,32	5alpha-reductase	44,60	finasteride	5alpha-reductase	MESH:D018120	6715	Chemical	Gene	binding|nmod|START_ENTITY binding|acl|steroid steroid|xcomp|END_ENTITY	Saturable binding of finasteride to steroid 5alpha-reductase as determinant of nonlinear pharmacokinetics .
20541645	0	finasteride	85,96	5alpha-reductase	57,73	finasteride	5alpha-reductase	MESH:D018120	6715	Chemical	Gene	START_ENTITY|nsubj|assays assays|nmod|control control|nmod|inhibitors inhibitors|amod|END_ENTITY	Enzyme-linked immunosorbent assays for doping control of 5alpha-reductase inhibitors finasteride and dutasteride .
25420363	0	finasteride	47,58	5alpha-reductase	14,30	finasteride	5alpha-reductase	MESH:D018120	6715	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|inhibition inhibition|amod|END_ENTITY	The effect of 5alpha-reductase inhibition with finasteride and dutasteride on bone mineral density in older men with benign_prostatic_hyperplasia .
25507347	0	finasteride	47,58	5alpha-reductase	14,30	finasteride	5alpha-reductase	MESH:D018120	6715	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|inhibition inhibition|amod|END_ENTITY	The effect of 5alpha-reductase inhibition with finasteride and dutasteride on bone mineral density in older men with benign_prostatic_hyperplasia .
19515843	0	finasteride	56,67	AKR1D1	45,51	finasteride	AKR1D1	MESH:D018120	6718	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of human steroid 5beta-reductase -LRB- AKR1D1 -RRB- by finasteride and structure of the enzyme-inhibitor complex .
10589774	0	finasteride	108,119	Androgen_receptor	0,17	finasteride	Androgen receptor	MESH:D018120	367	Chemical	Gene	treatment|amod|START_ENTITY appearing|nmod|treatment alterations|acl|appearing alterations|amod|END_ENTITY	Androgen_receptor gene alterations and chromosomal gains and losses_in_prostate_carcinomas appearing during finasteride treatment for benign_prostatic_hyperplasia .
12350485	0	finasteride	16,27	PSA	0,3	finasteride	PSA	MESH:D018120	354	Chemical	Gene	response|acl|START_ENTITY response|compound|END_ENTITY	PSA response to finasteride challenge in men with a serum PSA greater than 4 ng/ml and previous negative prostate biopsy : preliminary study .
12350485	0	finasteride	16,27	PSA	58,61	finasteride	PSA	MESH:D018120	354	Chemical	Gene	response|acl|START_ENTITY END_ENTITY|nsubj|response	PSA response to finasteride challenge in men with a serum PSA greater than 4 ng/ml and previous negative prostate biopsy : preliminary study .
16912265	0	finasteride	10,21	PSA	44,47	finasteride	PSA	MESH:D018120	354	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of finasteride on the sensitivity of PSA for detecting prostate_cancer .
21341547	0	finasteride	10,21	PSA	44,47	finasteride	PSA	MESH:D018120	9520	Chemical	Gene	START_ENTITY|nmod|sensitivity sensitivity|nmod|END_ENTITY	Effect of finasteride on the sensitivity of PSA to detect_prostate_cancer in rebiopsy series .
9044850	0	finasteride	59,70	PSA	199,202	finasteride	PSA	MESH:D018120	354	Chemical	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|nmod|gene gene|compound|END_ENTITY	Down-regulation of prostate-specific_antigen expression by finasteride through inhibition of complex formation between androgen_receptor and steroid_receptor-binding_consensus in the promoter of the PSA gene in LNCaP cells .
9949572	0	finasteride	11,22	PSA	49,52	finasteride	PSA	MESH:D018120	9520	Chemical	Gene	START_ENTITY|nmod|percentage percentage|nmod|END_ENTITY	-LSB- Effect of finasteride on the percentage of free PSA : implications in the early diagnosis of prostatic_cancer -RSB- .
16382684	0	finasteride	17,28	androgen_receptor	87,104	finasteride	androgen receptor	MESH:D018120	367	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|male_pattern_baldness male_pattern_baldness|acl:relcl|have have|dobj|gene gene|compound|END_ENTITY	Effectiveness of finasteride on patients with male_pattern_baldness who have different androgen_receptor gene polymorphism .
21386657	0	finasteride	29,40	androgen_receptor	58,75	finasteride	androgen receptor	MESH:D018120	367	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The antiandrogenic effect of finasteride against a mutant androgen_receptor .
24959691	0	finasteride	153,164	androgen_receptor	34,51	finasteride	androgen receptor	MESH:D018120	367	Chemical	Gene	use|amod|START_ENTITY density|nmod|use density|nsubj|evaluation evaluation|nmod|structure structure|compound|END_ENTITY	Immunohistochemical evaluation of androgen_receptor and nerve structure density in human prepuce from patients with persistent sexual side effects after finasteride use for androgenetic_alopecia .
9044850	0	finasteride	59,70	androgen_receptor	119,136	finasteride	androgen receptor	MESH:D018120	367	Chemical	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|nmod|END_ENTITY	Down-regulation of prostate-specific_antigen expression by finasteride through inhibition of complex formation between androgen_receptor and steroid_receptor-binding_consensus in the promoter of the PSA gene in LNCaP cells .
21115933	0	finasteride	22,33	chromogranin_A	53,67	finasteride	chromogranin A	MESH:D018120	1113	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|levels levels|compound|END_ENTITY	Comparative effect of finasteride and dutasteride on chromogranin_A levels .
10510925	0	finasteride	156,167	prostate-specific_antigen	6,31	finasteride	prostate-specific antigen	MESH:D018120	354	Chemical	Gene	comparing|dobj|START_ENTITY trial|acl|comparing results|nmod|trial changes|dep|results predict|dobj|changes predict|nsubj|END_ENTITY	Serum prostate-specific_antigen and prostate volume predict long-term changes in symptoms and flow rate : results of a four-year , randomized trial comparing finasteride versus placebo .
12410745	0	finasteride	78,89	prostate-specific_antigen	30,55	finasteride	prostate-specific antigen	MESH:D018120	354	Chemical	Gene	Changes|nmod|START_ENTITY Changes|nmod|forms forms|nmod|END_ENTITY	Changes in molecular forms of prostate-specific_antigen during treatment with finasteride .
17196507	0	finasteride	19,30	prostate-specific_antigen	58,83	finasteride	prostate-specific antigen	MESH:D018120	354	Chemical	Gene	START_ENTITY|nmod|concentrations concentrations|nmod|END_ENTITY	Effect of 1 mg/day finasteride on concentrations of serum prostate-specific_antigen in men with androgenic_alopecia : a randomised controlled trial .
26754047	0	finasteride	62,73	prostate-specific_antigen	19,44	finasteride	prostate-specific antigen	MESH:D018120	354	Chemical	Gene	therapy|amod|START_ENTITY insight|nmod|therapy insight|nmod|reduction reduction|amod|END_ENTITY	The new insight of prostate-specific_antigen reduction during finasteride therapy in aging men .
7506854	0	finasteride	10,21	prostate-specific_antigen	25,50	finasteride	prostate-specific antigen	MESH:D018120	354	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|density density|amod|END_ENTITY	Effect of finasteride on prostate-specific_antigen density .
7678930	0	finasteride	14,25	prostate-specific_antigen	29,54	finasteride	prostate-specific antigen	MESH:D018120	354	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of finasteride on prostate-specific_antigen in men with benign_prostatic_hyperplasia .
8986036	0	finasteride	101,112	prostate-specific_antigen	28,53	finasteride	prostate-specific antigen	MESH:D018120	354	Chemical	Gene	Lack|acl|START_ENTITY Lack|nmod|correlation correlation|nmod|density density|amod|END_ENTITY	Lack of correlation between prostate-specific_antigen density and prostatic shrinkage in response to finasteride therapy .
9044850	0	finasteride	59,70	prostate-specific_antigen	19,44	finasteride	prostate-specific antigen	MESH:D018120	354	Chemical	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|nmod|expression expression|amod|END_ENTITY	Down-regulation of prostate-specific_antigen expression by finasteride through inhibition of complex formation between androgen_receptor and steroid_receptor-binding_consensus in the promoter of the PSA gene in LNCaP cells .
9218012	0	finasteride	113,124	prostate-specific_antigen	24,49	finasteride	prostate-specific antigen	MESH:D018120	354	Chemical	Gene	effects|nmod|START_ENTITY variability|dep|effects variability|nmod|END_ENTITY	Biologic variability of prostate-specific_antigen and its usefulness as a marker for prostate_cancer : effects of finasteride .
9426721	0	finasteride	114,125	prostate-specific_antigen	27,52	finasteride	prostate-specific antigen	MESH:D018120	354	Chemical	Gene	terazosin|compound|START_ENTITY treated|nmod|terazosin benign_prostatic_hyperplasia|acl|treated free|nmod|benign_prostatic_hyperplasia free|dobj|levels levels|amod|END_ENTITY	Comparison of percent free prostate-specific_antigen levels in men with benign_prostatic_hyperplasia treated with finasteride , terazosin , or watchful waiting .
9586598	0	finasteride	113,124	prostate-specific_antigen	24,49	finasteride	prostate-specific antigen	MESH:D018120	354	Chemical	Gene	effects|nmod|START_ENTITY variability|dep|effects variability|nmod|END_ENTITY	Biologic variability of prostate-specific_antigen and its usefulness as a marker for prostate_cancer : effects of finasteride .
9697781	0	finasteride	15,26	prostate-specific_antigen	51,76	finasteride	prostate-specific antigen	MESH:D018120	354	Chemical	Gene	Treatment|nmod|START_ENTITY preserves|nsubj|Treatment preserves|dobj|usefulness usefulness|nmod|END_ENTITY	Treatment with finasteride preserves usefulness of prostate-specific_antigen in the detection of prostate_cancer : results of a randomized , double-blind , placebo-controlled clinical trial .
9703292	0	finasteride	14,25	prostate-specific_antigen	75,100	finasteride	prostate-specific antigen	MESH:D018120	354	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|men men|nmod|levels levels|compound|END_ENTITY	The effect of finasteride on the prostate gland in men with elevated serum prostate-specific_antigen levels .
16093979	0	finasteride	21,32	prostate_specific_antigen	36,61	finasteride	prostate specific antigen	MESH:D018120	354	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Long-term effects of finasteride on prostate_specific_antigen levels : results from the prostate_cancer prevention trial .
9649261	0	finasteride	13,24	prostate_specific_antigen	49,74	finasteride	prostate specific antigen	MESH:D018120	354	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|levels levels|compound|END_ENTITY	Influence of finasteride on free and total serum prostate_specific_antigen levels in men with benign_prostatic_hyperplasia .
11956450	0	finasteride	74,85	type_II_5alpha-reductase	33,57	finasteride	type II 5alpha-reductase	MESH:D018120	6716	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	The long-term effect of specific type_II_5alpha-reductase inhibition with finasteride on bone mineral density in men : results of a 4-year placebo controlled trial .
12201932	0	finasteride	11,22	vascular_endothelial_growth_factor	26,60	finasteride	vascular endothelial growth factor	MESH:D018120	7422	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of finasteride on vascular_endothelial_growth_factor .
12478093	0	finasteride	14,25	vascular_endothelial_growth_factor	47,81	finasteride	vascular endothelial growth factor	MESH:D018120	7422	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|density density|compound|END_ENTITY	The effect of finasteride on the expression of vascular_endothelial_growth_factor and microvessel density : a possible mechanism for decreased prostatic_bleeding in treated patients .
10952672	0	fipronil	60,68	RDL	113,116	fipronil	RDL	MESH:C082360	39054(Tax:7227)	Chemical	Gene	START_ENTITY|nmod|receptor receptor|appos|END_ENTITY	Single channel analysis of the blocking actions of BIDN and fipronil on a Drosophila_melanogaster GABA receptor -LRB- RDL -RRB- stably expressed in a Drosophila cell line .
19725538	0	fisetin	44,51	ERK	19,22	fisetin	ERK	MESH:C017875	5594	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Involvement of the ERK signaling pathway in fisetin reduces invasion and migration in the human lung_cancer cell line A549 .
25286082	6	fisetin	929,936	SIRT1	1032,1037	fisetin	PGC-1	MESH:C017875	19017(Tax:10090)	Chemical	Gene	increased|nsubj|START_ENTITY increased|dobj|activities activities|nmod|PPARs PPARs|appos|END_ENTITY	It was also revealed that fisetin increased the activities of PPARs and silent_mating_type_information_regulation_2_homologue_1 -LRB- SIRT1 -RRB- in a dose-dependent manner .
24341874	0	fisetin	47,54	p25	14,17	fisetin	p25	MESH:C017875	12569(Tax:10090)	Chemical	Gene	pathways|nmod|START_ENTITY pathways|amod|END_ENTITY	Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer 's _ disease transgenic_mice .
25660969	0	flagellin	10,19	IL-6	28,32	flagellin	IL-6	null	3569	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Bacterial flagellin induces IL-6 expression in human basophils .
24950354	0	flagellin	48,57	TLR5	34,38	flagellin	TLR5	null	7100	Chemical	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	A rationally designed form of the TLR5 agonist , flagellin , supports superior immunogenicity of Influenza B globular head vaccines .
23261530	0	flagellin	22,31	toll-like_receptor_5	43,63	flagellin	toll-like receptor 5	null	7100	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|xcomp|END_ENTITY	Clostridium_difficile flagellin stimulates toll-like_receptor_5 , and toxin B promotes flagellin-induced chemokine production via TLR5 .
24412598	0	flagellin	66,75	toll-like_receptor_5	100,120	flagellin	toll-like receptor 5	null	53791(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|upregulation upregulation|nmod|END_ENTITY	Exhaustive exercise increases the TNF-a production in response to flagellin via the upregulation of toll-like_receptor_5 in the large intestine in mice .
14675780	0	flavan-3-ols	62,74	ACE	45,48	flavan-3-ols	ACE	null	1636	Chemical	Gene	activity|nmod|START_ENTITY activity|appos|END_ENTITY	Inhibition of angiotensin_converting_enzyme -LRB- ACE -RRB- activity by flavan-3-ols and procyanidins .
14675780	0	flavan-3-ols	62,74	angiotensin_converting_enzyme	14,43	flavan-3-ols	angiotensin converting enzyme	null	1636	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Inhibition of angiotensin_converting_enzyme -LRB- ACE -RRB- activity by flavan-3-ols and procyanidins .
24239187	0	flavanone	40,49	transferrin	84,95	flavanone	transferrin	MESH:C028610	7018	Chemical	Gene	structure|nmod|START_ENTITY effect|nmod|structure effect|nmod|END_ENTITY	The effect of the skeleton structure of flavanone and flavonoid on interaction with transferrin .
10420850	0	flavin	73,79	C4a	53,56	flavin	C4a	MESH:C024132	720	Chemical	Gene	site|nmod|START_ENTITY site|amod|END_ENTITY	Computational analysis of the oxygen addition at the C4a site of reduced flavin in the bacterial luciferase bioluminescence reaction .
17088322	0	flavin	171,177	D-amino_acid_oxidase	27,47	flavin	D-amino acid oxidase	MESH:C024132	1610	Chemical	Gene	ring|compound|START_ENTITY si-face|nmod|ring located|nmod|si-face stretch|acl|located conformation|nmod|stretch variability|nmod|conformation structure|dep|variability structure|nmod|END_ENTITY	Crystal structure of human D-amino_acid_oxidase : context-dependent variability of the backbone conformation of the VAAGL hydrophobic stretch located at the si-face of the flavin ring .
16140270	0	flavin	21,27	NR1	39,42	flavin	NR1	MESH:C024132	27158	Chemical	Gene	reductase|compound|START_ENTITY reductase|appos|END_ENTITY	Role of a novel dual flavin reductase -LRB- NR1 -RRB- and an associated histidine triad protein -LRB- DCS-1 -RRB- in menadione-induced cytotoxicity .
11754736	0	flavin	46,52	d-amino_acid_oxidase	82,102	flavin	d-amino acid oxidase	MESH:C024132	1610	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of hydrogen bonds in association with flavin and substrate in flavoenzyme d-amino_acid_oxidase .
6893275	0	flavin	55,61	lipoamide_dehydrogenase	65,88	flavin	lipoamide dehydrogenase	MESH:C024132	1738	Chemical	Gene	studies|nmod|START_ENTITY studies|nmod|END_ENTITY	Magnetic circular dichroism studies on the active-site flavin of lipoamide_dehydrogenase .
23471972	0	flavin	28,34	quinone_reductase_2	60,79	flavin	quinone reductase 2	MESH:C024132	4835	Chemical	Gene	function|amod|START_ENTITY function|nmod|END_ENTITY	Chloroquine binding reveals flavin redox switch function of quinone_reductase_2 .
7638620	0	flavin_adenine_dinucleotide	15,42	CRY1	84,88	flavin adenine dinucleotide	CRY1	MESH:D005182	826470(Tax:3702)	Chemical	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of flavin_adenine_dinucleotide with the Arabidopsis blue light receptor CRY1 .
1201246	0	flavin_adenine_dinucleotide	61,88	glutathione_reductase	27,48	flavin adenine dinucleotide	glutathione reductase	MESH:D005182	2936	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Stimulation of erythrocyte glutathione_reductase activity by flavin_adenine_dinucleotide -LRB- FAD -RRB- in Malaysian adults and newborns and their parents .
1261528	0	flavin_adenine_dinucleotide	108,135	glutathione_reductase	32,53	flavin adenine dinucleotide	glutathione reductase	MESH:D005182	2936	Chemical	Gene	Response|acl|START_ENTITY Response|nmod|END_ENTITY	Response of plasma and red cell glutathione_reductase of several mammalian species and domestic chickens to flavin_adenine_dinucleotide .
11916686	0	flavin_mononucleotide	8,29	oxidoreductase	30,44	flavin mononucleotide	oxidoreductase	MESH:D005486	7296	Chemical	Gene	inactivation|amod|START_ENTITY inactivation|compound|END_ENTITY	NAD -LRB- P -RRB- H : flavin_mononucleotide oxidoreductase inactivation during 2,4,6-trinitrotoluene reduction .
10978155	0	flavodoxin	15,25	cobalamin-dependent_methionine_synthase	31,70	flavodoxin	cobalamin-dependent methionine synthase	null	4548	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of flavodoxin with cobalamin-dependent_methionine_synthase .
23727179	0	flavokawain_A	44,57	iNOS	15,19	flavokawain A	iNOS	MESH:C500809	18126(Tax:10090)	Chemical	Gene	Suppression|nmod|START_ENTITY Suppression|nmod|END_ENTITY	Suppression of iNOS and COX-2 expression by flavokawain_A via blockade of NF-kB and AP-1 activation in RAW 264.7 macrophages .
18591766	0	flavolignan	24,35	iNOS	95,99	flavolignan	iNOS	null	18126(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	The naturally occurring flavolignan , deoxypodophyllotoxin , inhibits lipopolysaccharide-induced iNOS expression through the NF-kappaB activation in RAW264 .7 macrophage cells .
11502282	0	flavone	104,111	cyclooxygenase-2	26,42	flavone	cyclooxygenase-2	MESH:C043562	19225(Tax:10090)	Chemical	Gene	START_ENTITY|advcl|Inhibition Inhibition|nmod|expression expression|amod|END_ENTITY	Inhibition of TPA-induced cyclooxygenase-2 expression and skin_inflammation in mice by wogonin , a plant flavone from Scutellaria radix .
17379515	0	flavone	71,78	estrogen_receptor	33,50	flavone	estrogen receptor	MESH:C043562	2099	Chemical	Gene	affinity|nmod|START_ENTITY affinity|compound|END_ENTITY	Synthesis , characterization , and estrogen_receptor binding affinity of flavone - , indole - , and furan-estradiol conjugates .
19881301	0	flavone	32,39	interleukin-4	43,56	flavone	interleukin-4	MESH:C043562	16189(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Suppressive effects of T-412 , a flavone on interleukin-4 production in T cells .
19074529	0	flavones	34,42	CYP2C9	13,19	flavones	CYP2C9	MESH:D047309	1559	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|Mechanism Mechanism|nmod|END_ENTITY	Mechanism of CYP2C9 inhibition by flavones and flavonols .
23252277	0	flavones	17,25	ERK	69,72	flavones	ERK	MESH:D047309	24338(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of total flavones of Rhododendra simsii on the activation of ERK induced by cerebral_ischemia-reperfusion in rats -RSB- .
20353017	0	flavones	17,25	UCP2	69,73	flavones	UCP2	MESH:D047309	54315(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of total flavones of hawthorn leafon -LRB- TFHL -RRB- on expression of UCP2 in liver of NASH rats -RSB- .
6474163	0	flavones	55,63	estrogen_synthetase	20,39	flavones	estrogen synthetase	MESH:D047309	1588	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of human estrogen_synthetase -LRB- aromatase -RRB- by flavones .
2919414	0	flavonoid	2,11	5-lipoxygenase	25,39	flavonoid	5-lipoxygenase	CHEBI:47916	240	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|nmod|END_ENTITY	A flavonoid inhibitor of 5-lipoxygenase inhibits leukotriene production following ischemia in gerbil brain .
8610110	0	flavonoid	50,59	CDK2	79,83	flavonoid	CDK2	CHEBI:47916	1017	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|nmod|END_ENTITY	Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2 , a cell cycle kinase .
15319488	0	flavonoid	80,89	CYP19	39,44	flavonoid	CYP19	CHEBI:47916	1588	Chemical	Gene	activity|nmod|START_ENTITY activity|appos|END_ENTITY	Induction and inhibition of aromatase -LRB- CYP19 -RRB- activity by natural and synthetic flavonoid compounds in H295R human adrenocortical_carcinoma cells .
25981047	0	flavonoid	95,104	MYB_transcription_factor	39,63	flavonoid	MYB transcription factor	CHEBI:47916	834578(Tax:3702)	Chemical	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Constitutive expression of Arabidopsis MYB_transcription_factor , AtMYB11 , in tobacco modulates flavonoid biosynthesis in favor of flavonol accumulation .
25981047	0	flavonoid	95,104	MYB_transcription_factor	39,63	flavonoid	MYB transcription factor	CHEBI:47916	834578(Tax:3702)	Chemical	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Constitutive expression of Arabidopsis MYB_transcription_factor , AtMYB11 , in tobacco modulates flavonoid biosynthesis in favor of flavonol accumulation .
12532018	0	flavonoid	61,70	anthocyanidin_reductase	8,31	flavonoid	anthocyanidin reductase	CHEBI:47916	842469(Tax:3702)	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of anthocyanidin_reductase , encoded by BANYULS in plant flavonoid biosynthesis .
11838316	0	flavonoid	18,27	caspase_3	38,47	flavonoid	caspase 3	CHEBI:47916	836	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Tartary buckwheat flavonoid activates caspase_3 and induces HL-60 cell apoptosis .
15380446	0	flavonoid	119,128	diacylglycerol_acyltransferase	23,53	flavonoid	diacylglycerol acyltransferase	CHEBI:47916	8694	Chemical	Gene	activity|nmod|START_ENTITY activity|nmod|END_ENTITY	Inhibitory activity of diacylglycerol_acyltransferase -LRB- DGAT -RRB- and microsomal triglyceride transfer protein -LRB- MTP -RRB- by the flavonoid , taxifolin , in HepG2 cells : potential role in the regulation of apolipoprotein_B secretion .
26311575	0	flavonoid	30,39	endothelin-1	60,72	flavonoid	endothelin-1	CHEBI:47916	1906	Chemical	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	Effect of micronized purified flavonoid fraction therapy on endothelin-1 and TNF-a levels in relation to antioxidant enzyme balance in the peripheral blood of women with varicose_veins .
17638904	0	flavonoid_apigenin	44,62	beta-catenin	12,24	flavonoid apigenin	beta-catenin	null	12387(Tax:10090)	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Blockade of beta-catenin signaling by plant flavonoid_apigenin suppresses prostate carcinogenesis in TRAMP mice .
16648565	0	flavonoid_apigenin	12,30	tumor_necrosis_factor-related_apoptosis-inducing_ligand	67,122	flavonoid apigenin	tumor necrosis factor-related apoptosis-inducing ligand	null	8743	Chemical	Gene	sensitizes|nsubj|START_ENTITY sensitizes|nmod|END_ENTITY	The dietary flavonoid_apigenin sensitizes malignant_tumor cells to tumor_necrosis_factor-related_apoptosis-inducing_ligand .
10652242	0	flavonoid_apigenin	4,22	vitamin_D_receptor	34,52	flavonoid apigenin	vitamin D receptor	null	7421	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	The flavonoid_apigenin suppresses vitamin_D_receptor expression and vitamin_D responsiveness in normal human keratinocytes .
11591177	0	flavonoid_baicalin	15,33	androgen_receptor	66,83	flavonoid baicalin	androgen receptor	null	367	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of the flavonoid_baicalin and its metabolite baicalein on androgen_receptor expression , cell cycle progression and apoptosis of prostate_cancer cell lines .
17093006	0	flavonoid_chrysin	15,32	ABCG2	102,107	flavonoid chrysin	ABCG2	null	312382(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|dep|involvement involvement|nmod|END_ENTITY	Effects of the flavonoid_chrysin on nitrofurantoin pharmacokinetics in rats : potential involvement of ABCG2 .
16289948	0	flavonoid_eriodictyol	17,38	tyrosinase	42,52	flavonoid eriodictyol	tyrosinase	null	7299	Chemical	Gene	Oxidation|nmod|START_ENTITY Oxidation|nmod|END_ENTITY	Oxidation of the flavonoid_eriodictyol by tyrosinase .
21618507	0	flavonoid_fisetin	151,168	Akt	49,52	flavonoid fisetin	Akt	null	207	Chemical	Gene	signaling|nmod|START_ENTITY signaling|nsubj|END_ENTITY	Dual inhibition of phosphatidylinositol_3-kinase / Akt and mammalian_target_of_rapamycin signaling in human nonsmall cell lung_cancer cells by a dietary flavonoid_fisetin .
23618921	0	flavonoid_fisetin	119,136	Nrf2	51,55	flavonoid fisetin	Nrf2	null	4780	Chemical	Gene	mediates|nmod|START_ENTITY mediates|nsubj|regulation regulation|nmod|END_ENTITY	Concurrent regulation of the transcription factors Nrf2 and ATF4 mediates the enhancement of glutathione levels by the flavonoid_fisetin .
18922931	0	flavonoid_fisetin	16,33	androgen_receptor	43,60	flavonoid fisetin	androgen receptor	null	367	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|signaling signaling|compound|END_ENTITY	A novel dietary flavonoid_fisetin inhibits androgen_receptor signaling and tumor growth in athymic nude_mice .
21720915	0	flavonoid_hesperetin	47,67	AhR	77,80	flavonoid hesperetin	AhR	null	196	Chemical	Gene	START_ENTITY|nmod|pathway pathway|compound|END_ENTITY	Interaction of a functionalized complex of the flavonoid_hesperetin with the AhR pathway and CYP1A1 expression : involvement in its protective effects against benzo -LSB- a -RSB- pyrene-induced oxidative stress in human skin .
25110319	0	flavonoid_isoliquiritigenin	13,40	AhR	73,76	flavonoid isoliquiritigenin	AhR	null	196	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|activity activity|nmod|END_ENTITY	The licorice flavonoid_isoliquiritigenin reduces DNA-binding activity of AhR in MCF-7 cells .
20033868	0	flavonoid_isoliquiritigenin	13,40	cyclooxygenase-2	74,90	flavonoid isoliquiritigenin	cyclooxygenase-2	null	5743	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	The licorice flavonoid_isoliquiritigenin suppresses phorbol_ester-induced cyclooxygenase-2 expression in the non-tumorigenic MCF-10A breast cell line .
22449725	0	flavonoid_luteolin	12,30	Aurora_B	40,48	flavonoid luteolin	Aurora B	null	9212	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	The dietary flavonoid_luteolin inhibits Aurora_B kinase activity and blocks proliferation of cancer cells .
14514640	0	flavonoid_naringenin	70,90	apolipoprotein_B	29,45	flavonoid naringenin	apolipoprotein B	null	54225(Tax:10116)	Chemical	Gene	secretion|nmod|START_ENTITY END_ENTITY|acl|secretion	Inhibition of net HepG2 cell apolipoprotein_B secretion by the citrus flavonoid_naringenin involves activation of phosphatidylinositol 3-kinase , independent of insulin_receptor_substrate-1 phosphorylation .
16376383	0	flavonoids	34,44	20alpha-hydroxysteroid_dehydrogenase	48,84	flavonoids	20alpha-hydroxysteroid dehydrogenase	MESH:D005419	105349(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Characteristics and inhibition by flavonoids of 20alpha-hydroxysteroid_dehydrogenase activity in mouse tissues .
1656994	0	flavonoids	62,72	5-lipoxygenase	24,38	flavonoids	5-lipoxygenase	MESH:D005419	240	Chemical	Gene	additives|amod|START_ENTITY Inhibition|nmod|additives Inhibition|nmod|END_ENTITY	Inhibition of mammalian 5-lipoxygenase and cyclo-oxygenase by flavonoids and phenolic dietary additives .
26024248	0	flavonoids	117,127	5-lipoxygenase	79,93	flavonoids	5-lipoxygenase	MESH:D005419	240	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Combined Autodock and comparative molecular field analysis study on predicting 5-lipoxygenase inhibitory activity of flavonoids isolated from Spatholobus suberectus Dunn .
2907559	0	flavonoids	137,147	5-lipoxygenase	26,40	flavonoids	5-lipoxygenase	MESH:D005419	25290(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Selectivity Selectivity|nmod|END_ENTITY	Selectivity of neutrophil 5-lipoxygenase and cyclo-oxygenase inhibition by an anti-inflammatory flavonoid_glycoside and related aglycone flavonoids .
19007764	0	flavonoids	66,76	AKR1C3	0,6	flavonoids	AKR1C3	MESH:D005419	8644	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nmod|effect	AKR1C3 as a potential target for the inhibitory effect of dietary flavonoids .
16964758	0	flavonoids	61,71	AP-1	35,39	flavonoids	AP-1	MESH:D005419	3727	Chemical	Gene	pathway|nmod|START_ENTITY pathway|nsubj|Modulation Modulation|nmod|END_ENTITY	Modulation of activator_protein-1 -LRB- AP-1 -RRB- and MAPK pathway by flavonoids in human prostate_cancer PC3 cells .
11322924	0	flavonoids	32,42	CDK2	133,137	flavonoids	CDK2	MESH:D005419	1017	Chemical	Gene	Effects|nmod|START_ENTITY Effects|dep|regulation regulation|nmod|END_ENTITY	Effects of structurally related flavonoids on cell cycle progression of human melanoma cells : regulation of cyclin-dependent kinases CDK2 and CDK1 .
20402563	0	flavonoids	43,53	CYP2A6	78,84	flavonoids	CYP2A6	MESH:D005419	1548	Chemical	Gene	START_ENTITY|nmod|activity activity|appos|END_ENTITY	In vitro modulation of naturally occurring flavonoids on cytochrome_P450_2A6 -LRB- CYP2A6 -RRB- activity .
24431079	0	flavonoids	8,18	CYP2C	28,33	flavonoids	CYP2C	MESH:D005419	29277(Tax:10116)	Chemical	Gene	modulate|nsubj|START_ENTITY modulate|dobj|END_ENTITY	Dietary flavonoids modulate CYP2C to improve drug oral bioavailability and their qualitative/quantitative structure-activity relationship .
11737987	0	flavonoids	50,60	CYP3A4	20,26	flavonoids	CYP3A4	MESH:D005419	1576	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Inhibition of human CYP3A4 activity by grapefruit flavonoids , furanocoumarins and related compounds .
23567286	0	flavonoids	25,35	Catalase	0,8	flavonoids	Catalase	MESH:D005419	531682(Tax:9913)	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|END_ENTITY	Catalase is inhibited by flavonoids .
21725884	0	flavonoids	30,40	Cathepsin_K	67,78	flavonoids	Cathepsin K	MESH:D005419	1513	Chemical	Gene	START_ENTITY|nmod|Drynariae Drynariae|nmod|END_ENTITY	Interventional value of total flavonoids from Rhizoma Drynariae on Cathepsin_K , a potential target of osteoporosis .
16543677	0	flavonoids	40,50	Cbfa1	14,19	flavonoids	Cbfa1	MESH:D005419	367218(Tax:10116)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of Cbfa1 expression by total flavonoids of Herba epimedii .
1694261	0	flavonoids	83,93	DT-diaphorase	65,78	flavonoids	DT-diaphorase	MESH:D005419	24314(Tax:10116)	Chemical	Gene	oxidoreductase|nmod|START_ENTITY oxidoreductase|appos|END_ENTITY	Inhibition of rat liver NAD -LRB- P -RRB- H : quinone acceptor oxidoreductase -LRB- DT-diaphorase -RRB- by flavonoids isolated from the Chinese herb scutellariae radix -LRB- Huang Qin -RRB- .
14669262	0	flavonoids	30,40	E-selectin	44,54	flavonoids	E-selectin	MESH:D005419	6401	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Inhibitory effects of several flavonoids on E-selectin expression on human umbilical vein endothelial cells stimulated by tumor_necrosis_factor-alpha .
16014620	0	flavonoids	103,113	ERK	78,81	flavonoids	ERK	MESH:D005419	5594	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Modulation of apoptosis in HaCaT keratinocytes via differential regulation of ERK signaling pathway by flavonoids .
15710766	0	flavonoids	103,113	HERG	78,82	flavonoids	HERG	MESH:D005419	3757	Chemical	Gene	blockade|nmod|START_ENTITY blockade|compound|END_ENTITY	QTc_prolongation by grapefruit juice and its potential pharmacological basis : HERG channel blockade by flavonoids .
19470239	0	flavonoids	22,32	IL-8	54,58	flavonoids	IL-8	MESH:D005419	3576	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Inhibitory effects of flavonoids on TNF-alpha-induced IL-8 gene expression in HEK 293 cells .
17976262	0	flavonoids	21,31	MCT1	66,70	flavonoids	MCT1	MESH:D005419	6566	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Inhibition effect of flavonoids on monocarboxylate_transporter_1 -LRB- MCT1 -RRB- in Caco-2 cells .
11406849	0	flavonoids	25,35	MK2	44,47	flavonoids	MK2	MESH:D005419	9261	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	In vitro cytotoxicity of flavonoids against MK2 and C6 tumour cells .
11714358	0	flavonoids	70,80	Monoamine_oxidase_B	0,19	flavonoids	Monoamine oxidase B	MESH:D005419	4129	Chemical	Gene	activities|nmod|START_ENTITY activities|amod|END_ENTITY	Monoamine_oxidase_B and free radical scavenging activities of natural flavonoids in Melastoma candidum D. Don .
16484540	0	flavonoids	24,34	NF-kappaB	76,85	flavonoids	NF-kappaB	MESH:D005419	18033(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Functional diversity of flavonoids in the inhibition of the proinflammatory NF-kappaB , IRF , and Akt signaling pathways in murine intestinal epithelial cells .
10470145	0	flavonoids	57,67	P-glycoprotein	0,14	flavonoids	P-glycoprotein	MESH:D005419	5243	Chemical	Gene	cytotoxicity|nmod|START_ENTITY affect|dobj|cytotoxicity affect|nsubj|END_ENTITY	P-glycoprotein -LRB- Pgp -RRB- does not affect the cytotoxicity of flavonoids from Sophora flavescens , which also have no effects on Pgp action .
11262086	0	flavonoids	20,30	P-glycoprotein	64,78	flavonoids	P-glycoprotein	MESH:D005419	5243	Chemical	Gene	C-Isoprenylation|nmod|START_ENTITY enhances|nsubj|C-Isoprenylation enhances|dobj|affinity affinity|nmod|END_ENTITY	C-Isoprenylation of flavonoids enhances binding affinity toward P-glycoprotein and modulation of cancer cell chemoresistance .
11915946	0	flavonoids	14,24	P-glycoprotein	66,80	flavonoids	P-glycoprotein	MESH:D005419	5243	Chemical	Gene	Modulation|nmod|START_ENTITY resistance|amod|Modulation mediated|nsubj|resistance mediated|nmod|transporters transporters|amod|END_ENTITY	Modulation by flavonoids of cell multidrug resistance mediated by P-glycoprotein and related ABC transporters .
12210557	0	flavonoids	36,46	P-glycoprotein	89,103	flavonoids	P-glycoprotein	MESH:D005419	5243	Chemical	Gene	discovery|nmod|START_ENTITY advances|nmod|discovery advances|nmod|resistance resistance|amod|binding binding|nmod|multidrug multidrug|amod|END_ENTITY	Recent advances in the discovery of flavonoids and analogs with high-affinity binding to P-glycoprotein responsible for cancer cell multidrug resistance .
16059668	0	flavonoids	36,46	P-glycoprotein	50,64	flavonoids	P-glycoprotein	MESH:D005419	67078(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	An in silico approach for screening flavonoids as P-glycoprotein inhibitors based on a Bayesian-regularized neural network .
16494971	0	flavonoids	42,52	P-glycoprotein	64,78	flavonoids	P-glycoprotein	MESH:D005419	5243	Chemical	Gene	START_ENTITY|nmod|domain domain|amod|END_ENTITY	In silico modelling of the interaction of flavonoids with human P-glycoprotein nucleotide-binding domain .
18951251	0	flavonoids	19,29	P-glycoprotein	65,79	flavonoids	P-glycoprotein	MESH:D005419	5243	Chemical	Gene	START_ENTITY|nmod|transport transport|nmod|cimetidine cimetidine|nmod|transporters transporters|amod|END_ENTITY	Effects of dietary flavonoids on the transport of cimetidine via P-glycoprotein and cationic transporters in Caco-2 and LLC-PK1 cell models .
16427264	0	flavonoids	68,78	PBR	16,19	flavonoids	PBR	MESH:D005419	706	Chemical	Gene	Upregulation|nmod|START_ENTITY Upregulation|nmod|expression expression|compound|END_ENTITY	Upregulation of PBR mRNA expression in human neuroblastoma cells by flavonoids .
16142647	0	flavonoids	58,68	Phospholipase_Cgamma1	0,21	flavonoids	Phospholipase Cgamma1	MESH:D005419	18803(Tax:10090)	Chemical	Gene	activities|nmod|START_ENTITY activities|amod|END_ENTITY	Phospholipase_Cgamma1 inhibitory activities of prenylated flavonoids isolated from Erythrina senegalensis .
23908081	0	flavonoids	13,23	SFRP4	36,41	flavonoids	SFRP4	MESH:D005419	89803(Tax:10116)	Chemical	Gene	control|nsubj|START_ENTITY control|dobj|expression expression|compound|END_ENTITY	-LSB- Chuju total flavonoids control the SFRP4 expression in Wnt pathway in rheumatoid_arthritis model rats -RSB- .
12951485	0	flavonoids	33,43	Tyrosinase	0,10	flavonoids	Tyrosinase	MESH:D005419	7299	Chemical	Gene	prenylated|dobj|START_ENTITY prenylated|nsubj|END_ENTITY	Tyrosinase inhibitory prenylated flavonoids from Sophora flavescens .
26834825	0	flavonoids	34,44	Tyrosinase	0,10	flavonoids	Tyrosinase	MESH:D005419	7299	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Tyrosinase inhibitory activity of flavonoids from Artocarpus heterophyllous .
1469950	0	flavonoids	46,56	adenosine_deaminase	23,42	flavonoids	adenosine deaminase	MESH:D005419	100	Chemical	Gene	compounds|amod|START_ENTITY END_ENTITY|nmod|compounds	In vitro inhibition of adenosine_deaminase by flavonoids and related compounds .
8720382	0	flavonoids	83,93	adenosine_deaminase	14,33	flavonoids	adenosine deaminase	MESH:D005419	100	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activity activity|amod|END_ENTITY	Inhibition of adenosine_deaminase activity of aortic endothelial cells by selected flavonoids .
10426807	0	flavonoids	41,51	aryl_hydrocarbon_receptor	71,96	flavonoids	aryl hydrocarbon receptor	MESH:D005419	11622(Tax:10090)	Chemical	Gene	progression|nmod|START_ENTITY Suppression|nmod|progression Suppression|dep|dependence dependence|nmod|END_ENTITY	Suppression of cell cycle progression by flavonoids : dependence on the aryl_hydrocarbon_receptor .
12644593	0	flavonoids	55,65	aryl_hydrocarbon_receptor	142,167	flavonoids	aryl hydrocarbon receptor	MESH:D005419	11622(Tax:10090)	Chemical	Gene	activity|nmod|START_ENTITY activity|nmod|END_ENTITY	Species-specific transcriptional activity of synthetic flavonoids in guinea_pig and mouse cells as a result of differential activation of the aryl_hydrocarbon_receptor to interact with dioxin-responsive elements .
17560542	0	flavonoids	71,81	aryl_hydrocarbon_receptor	24,49	flavonoids	aryl hydrocarbon receptor	MESH:D005419	196	Chemical	Gene	START_ENTITY|nsubj|Interaction Interaction|nmod|END_ENTITY	Interaction between the aryl_hydrocarbon_receptor and its antagonists , flavonoids .
12112014	0	flavonoids	54,64	bone_sialoprotein	14,31	flavonoids	bone sialoprotein	MESH:D005419	24477(Tax:10116)	Chemical	Gene	transcription|nmod|START_ENTITY transcription|compound|END_ENTITY	Activation of bone_sialoprotein gene transcription by flavonoids is mediated through an inverted CCAAT box in ROS 17/2 .8 cells .
25549925	0	flavonoids	35,45	carbonyl_reductase_1	70,90	flavonoids	carbonyl reductase 1	MESH:D005419	873	Chemical	Gene	relationship|nmod|START_ENTITY relationship|nmod|END_ENTITY	Structure-activity relationship of flavonoids as potent inhibitors of carbonyl_reductase_1 -LRB- CBR1 -RRB- .
25036175	0	flavonoids	15,25	cathepsin_K	35,46	flavonoids	cathepsin K	MESH:D005419	29175(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|expression expression|compound|END_ENTITY	Drynaria total flavonoids decrease cathepsin_K expression in ovariectomized rats .
10920275	0	flavonoids	15,25	cyclooxygenase-2	29,45	flavonoids	cyclooxygenase-2	MESH:D005419	5743	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Suppression by flavonoids of cyclooxygenase-2 promoter-dependent transcriptional activity in colon_cancer cells : structure-activity relationship .
15225597	0	flavonoids	10,20	cyclooxygenase-2	38,54	flavonoids	cyclooxygenase-2	MESH:D005419	5743	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|transcription transcription|amod|END_ENTITY	Effect of flavonoids and vitamin_E on cyclooxygenase-2 -LRB- COX-2 -RRB- transcription .
20402563	0	flavonoids	43,53	cytochrome_P450_2A6	57,76	flavonoids	cytochrome P450 2A6	MESH:D005419	1548	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	In vitro modulation of naturally occurring flavonoids on cytochrome_P450_2A6 -LRB- CYP2A6 -RRB- activity .
10673981	0	flavonoids	47,57	cytochrome_c	66,78	flavonoids	cytochrome c	MESH:D005419	54205	Chemical	Gene	START_ENTITY|nmod|release release|amod|END_ENTITY	Induction of apoptosis by apigenin and related flavonoids through cytochrome_c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells .
15135307	0	flavonoids	127,137	epidermal_growth_factor_receptor	25,57	flavonoids	epidermal growth factor receptor	MESH:D005419	1956	Chemical	Gene	kinase|nmod|START_ENTITY kinase|compound|END_ENTITY	Transinactivation of the epidermal_growth_factor_receptor tyrosine kinase and focal_adhesion_kinase phosphorylation by dietary flavonoids : effect on invasive potential of human carcinoma cells .
19914244	0	flavonoids	36,46	estrogen-related_receptor_gamma	52,83	flavonoids	estrogen-related receptor gamma	MESH:D005419	2104	Chemical	Gene	relationship|nmod|START_ENTITY relationship|nmod|END_ENTITY	Structural activity relationship of flavonoids with estrogen-related_receptor_gamma .
15185748	0	flavonoids	12,22	estrogen_receptor_alpha	32,55	flavonoids	estrogen receptor alpha	MESH:D005419	2099	Chemical	Gene	modulate|nsubj|START_ENTITY modulate|dobj|END_ENTITY	Nutritional flavonoids modulate estrogen_receptor_alpha signaling .
16608212	0	flavonoids	35,45	estrogen_synthase	60,77	flavonoids	estrogen synthase	MESH:D005419	1588	Chemical	Gene	START_ENTITY|nmod|activity activity|appos|END_ENTITY	Effect of hop -LRB- Humulus lupulus L. -RRB- flavonoids on aromatase -LRB- estrogen_synthase -RRB- activity .
1329770	0	flavonoids	39,49	glutathione_reductase	14,35	flavonoids	glutathione reductase	MESH:D005419	2936	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of glutathione_reductase by flavonoids .
16608212	0	flavonoids	35,45	hop	10,13	flavonoids	hop	MESH:D005419	84525	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of hop -LRB- Humulus lupulus L. -RRB- flavonoids on aromatase -LRB- estrogen_synthase -RRB- activity .
3151014	0	flavonoids	30,40	lipoxygenase	44,56	flavonoids	lipoxygenase	MESH:D005419	547836(Tax:3847)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Screening of the influence of flavonoids on lipoxygenase and cyclooxygenase activity , as well as on nonenzymic lipid oxidation .
8951505	0	flavonoids	52,62	lysoPAF_acetyltransferase	14,39	flavonoids	lysoPAF acetyltransferase	MESH:D005419	361467(Tax:10116)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activity activity|amod|END_ENTITY	Inhibition of lysoPAF_acetyltransferase activity by flavonoids .
17886198	0	flavonoids	88,98	matrix_metalloproteinase-1	37,63	flavonoids	matrix metalloproteinase-1	MESH:D005419	4312	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|amod|END_ENTITY	Inhibition of mammalian collagenase , matrix_metalloproteinase-1 , by naturally-occurring flavonoids .
21606625	0	flavonoids	11,21	matrix_metalloproteinase-13	25,52	flavonoids	matrix metalloproteinase-13	MESH:D005419	4322	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effects of flavonoids on matrix_metalloproteinase-13 expression of interleukin-1b-treated articular chondrocytes and their cellular mechanisms : inhibition of c-Fos/AP -1 and JAK/STAT signaling pathways .
18640042	0	flavonoids	35,45	neuraminidase	65,78	flavonoids	neuraminidase	MESH:D005419	4758	Chemical	Gene	relationship|nmod|START_ENTITY END_ENTITY|nsubj|relationship	Structure-activity relationship of flavonoids as influenza virus neuraminidase inhibitors and their in vitro anti-viral activities .
6427052	0	flavonoids	11,21	ornithine_decarboxylase	97,120	flavonoids	ornithine decarboxylase	MESH:D005419	18263(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of flavonoids and antioxidants on 12-O-tetradecanoyl-phorbol-13-acetate-caused epidermal ornithine_decarboxylase induction and tumor promotion in relation to lipoxygenase inhibition by these compounds .
20487633	0	flavonoids	62,72	p-glycoprotein	35,49	flavonoids	p-glycoprotein	MESH:D005419	5243	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Modulation of multidrug resistance p-glycoprotein activity by flavonoids and honokiol in human doxorubicin - resistant sarcoma cells -LRB- MES-SA/DX -5 -RRB- : implications for natural sedatives as chemosensitizing agents in cancer therapy .
17085029	0	flavonoids	63,73	prostate_specific_antigen	19,44	flavonoids	prostate specific antigen	MESH:D005419	354	Chemical	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|nmod|END_ENTITY	Down-regulation of prostate_specific_antigen in LNCaP cells by flavonoids from the pollen of Brassica_napus_L .
24047800	0	flavonoids	23,33	protein_tyrosine_phosphatase_1B	37,68	flavonoids	protein tyrosine phosphatase 1B	MESH:D005419	5770	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Evaluation of licorice flavonoids as protein_tyrosine_phosphatase_1B inhibitors .
14646171	0	flavonoids	68,78	syk	14,17	flavonoids	syk	MESH:D005419	6850	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activity activity|compound|END_ENTITY	Inhibition of syk activity and degranulation of human mast cells by flavonoids .
16544938	0	flavonoids	52,62	thyroid_peroxidase	14,32	flavonoids	thyroid peroxidase	MESH:D005419	7173	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|uniflora uniflora|amod|END_ENTITY	Inhibition of thyroid_peroxidase by Myrcia uniflora flavonoids .
8924586	0	flavonoids	44,54	thyroid_peroxidase	14,32	flavonoids	thyroid peroxidase	MESH:D005419	7173	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of thyroid_peroxidase by dietary flavonoids .
14669262	0	flavonoids	30,40	tumor_necrosis_factor-alpha	122,149	flavonoids	tumor necrosis factor-alpha	MESH:D005419	7124	Chemical	Gene	effects|nmod|START_ENTITY stimulated|nsubj|effects stimulated|nmod|END_ENTITY	Inhibitory effects of several flavonoids on E-selectin expression on human umbilical vein endothelial cells stimulated by tumor_necrosis_factor-alpha .
14977446	0	flavonoids	26,36	tumor_necrosis_factor-alpha	40,67	flavonoids	tumor necrosis factor-alpha	MESH:D005419	21926(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Inhibitory effect of some flavonoids on tumor_necrosis_factor-alpha production in lipopolysaccharide-stimulated mouse macrophage cell line J774 .1 .
24720993	0	flavonoids	123,133	tyramine_oxidase	78,94	flavonoids	tyramine oxidase	MESH:D005419	4129	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	An automated sequential injection spectrophotometric method for evaluation of tyramine_oxidase inhibitory activity of some flavonoids .
10705726	0	flavonoids	28,38	tyrosinase	14,24	flavonoids	tyrosinase	MESH:D005419	7299	Chemical	Gene	stilbenes|compound|START_ENTITY END_ENTITY|nmod|stilbenes	Inhibition of tyrosinase by flavonoids , stilbenes and related 4-substituted_resorcinols : structure-activity investigations .
12765534	0	flavonoids	27,37	tyrosinase	66,76	flavonoids	tyrosinase	MESH:D005419	7299	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	Inhibitory effects of some flavonoids on the activity of mushroom tyrosinase .
15595416	0	flavonoids	11,21	tyrosinase	25,35	flavonoids	tyrosinase	MESH:D005419	7299	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Prenylated flavonoids as tyrosinase inhibitors .
16159166	0	flavonoids	32,42	tyrosinase	98,108	flavonoids	tyrosinase	MESH:D005419	7299	Chemical	Gene	Isolation|nmod|START_ENTITY Isolation|nmod|END_ENTITY	Isolation and identification of flavonoids in licorice and a study of their inhibitory effects on tyrosinase .
20230793	0	flavonoids_hesperetin	11,32	TNF-alpha	79,88	flavonoids hesperetin	TNF-alpha	null	21926(Tax:10090)	Chemical	Gene	block|nsubj|START_ENTITY block|dobj|actions actions|nmod|END_ENTITY	The citrus flavonoids_hesperetin and naringenin block the lipolytic actions of TNF-alpha in mouse adipocytes .
18567791	0	flavonol	13,21	rol1	63,67	flavonol	rol1	CHEBI:5078	844193(Tax:3702)	Chemical	Gene	profile|amod|START_ENTITY profile|nmod|END_ENTITY	The modified flavonol glycosylation profile in the Arabidopsis rol1 mutants results in alterations in plant growth and cell shape formation .
9838217	0	flavonol_fisetin	17,33	polyphenol_oxidase	37,55	flavonol fisetin	polyphenol oxidase	null	5498	Chemical	Gene	Oxidation|nmod|START_ENTITY Oxidation|nmod|END_ENTITY	Oxidation of the flavonol_fisetin by polyphenol_oxidase .
19917299	0	flavonols	24,33	BDNF	43,47	flavonols	BDNF	MESH:D044948	12064(Tax:10090)	Chemical	Gene	modulate|nsubj|START_ENTITY modulate|dobj|END_ENTITY	Anti-depressant natural flavonols modulate BDNF and beta amyloid in neurons and hippocampus of double TgAD mice .
7475916	0	flavonols	11,20	P-glycoprotein	24,38	flavonols	P-glycoprotein	MESH:D044948	287115(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effects of flavonols on P-glycoprotein activity in cultured rat hepatocytes .
9373241	0	flavopiridol	44,56	Bcl-2	71,76	flavopiridol	Bcl-2	MESH:C077990	596	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	The novel cyclin-dependent kinase inhibitor flavopiridol downregulates Bcl-2 and induces growth_arrest and apoptosis in chronic_B-cell_leukemia lines .
10496352	0	flavopiridol	22,34	MRP1	40,44	flavopiridol	MRP1	MESH:C077990	4363	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Potent interaction of flavopiridol with MRP1 .
10656453	0	flavopiridol	76,88	c-erbB-2	41,49	flavopiridol	c-erbB-2	MESH:C077990	2064	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|cells cells|amod|END_ENTITY	Induction of apoptosis and inhibition of c-erbB-2 in breast_cancer cells by flavopiridol .
15014036	0	flavopiridol	32,44	p21	14,17	flavopiridol	p21	MESH:C077990	644914	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Abrogation of p21 expression by flavopiridol enhances depsipeptide-mediated apoptosis in malignant_pleural_mesothelioma cells .
18754843	0	flecainide	31,41	CYP2D6	76,82	flecainide	CYP2D6	MESH:D005424	1565	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|relation relation|nmod|END_ENTITY	Pharmacokinetic interaction of flecainide and paroxetine in relation to the CYP2D6 * 10 allele in healthy Korean subjects .
10758053	0	flecainide	11,21	SCN5A	43,48	flecainide	SCN5A	MESH:D005424	6331	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|mutation mutation|compound|END_ENTITY	Effects of flecainide in patients with new SCN5A mutation : mutation-specific therapy for long-QT_syndrome ?
11333173	0	flecainide	49,59	SCN5A	94,99	flecainide	SCN5A	MESH:D005424	6331	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	Normalization of ventricular repolarization with flecainide in long_QT_syndrome patients with SCN5A : DeltaKPQ mutation .
23635804	0	flecainide	65,75	SCN5A	0,5	flecainide	SCN5A	MESH:D005424	6331	Chemical	Gene	concentration|compound|START_ENTITY range|nmod|concentration affects|dobj|range affects|nsubj|haplotype haplotype|nummod|END_ENTITY	SCN5A promoter haplotype affects the therapeutic range for serum flecainide concentration in Asian patients .
17023504	0	flecainide	11,21	Scn5a	68,73	flecainide	Scn5a	MESH:D005424	20271(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|properties properties|nmod|+ +|amod|END_ENTITY	Effects of flecainide and quinidine on arrhythmogenic properties of Scn5a + / Delta murine hearts modelling long_QT_syndrome 3 .
17303635	0	flecainide	11,21	Scn5a	68,73	flecainide	Scn5a	MESH:D005424	20271(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|properties properties|nmod|/ /|compound|END_ENTITY	Effects of flecainide and quinidine on arrhythmogenic properties of Scn5a + / - murine hearts modelling the Brugada_syndrome .
19078778	0	flecainide	32,42	myotonic_dystrophy	57,75	flecainide	myotonic dystrophy	MESH:D005424	1760	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|END_ENTITY	A cautionary tale : the risks of flecainide treatment for myotonic_dystrophy .
10515319	0	flesinoxan	28,38	5-HT1A_receptor	4,19	flesinoxan	5-HT1A receptor	MESH:C056895	3350	Chemical	Gene	shares|compound|START_ENTITY shares|amod|END_ENTITY	The 5-HT1A_receptor agonist flesinoxan shares discriminative stimulus properties with some 5-HT2_receptor antagonists .
12373416	0	flesinoxan	66,76	5-HT1A_receptor	42,57	flesinoxan	5-HT1A receptor	MESH:C056895	3350	Chemical	Gene	START_ENTITY|nsubj|responses responses|nmod|agonist agonist|amod|END_ENTITY	Hormonal and temperature responses to the 5-HT1A_receptor agonist flesinoxan in normal volunteers .
7589185	0	flesinoxan	26,36	5-HT1A_receptor	40,55	flesinoxan	5-HT1A receptor	MESH:C056895	3350	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|agonist agonist|amod|END_ENTITY	The anxiolytic effects of flesinoxan , a 5-HT1A_receptor agonist , are not related to its neuroendocrine effects .
7972301	0	flesinoxan	85,95	5-HT1A_receptor	60,75	flesinoxan	5-HT1A receptor	MESH:C056895	15550(Tax:10090)	Chemical	Gene	actions|acl|START_ENTITY actions|amod|agonist agonist|amod|END_ENTITY	Antianxiety and behavioral suppressant actions of the novel 5-HT1A_receptor agonist , flesinoxan .
8263314	0	flesinoxan	22,32	5-HT1A_receptor	36,51	flesinoxan	5-HT1A receptor	MESH:C056895	3350	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	An open study of oral flesinoxan , a 5-HT1A_receptor agonist , in treatment-resistant depression .
8614706	0	flesinoxan	4,14	5-HT1A_receptor	15,30	flesinoxan	5-HT1A receptor	MESH:C056895	3350	Chemical	Gene	challenge|amod|START_ENTITY challenge|amod|END_ENTITY	The flesinoxan 5-HT1A_receptor challenge in major depression and suicidal behavior .
8888384	0	flesinoxan	39,49	5-HT1A_receptor	15,30	flesinoxan	5-HT1A receptor	MESH:C056895	3350	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|agonist agonist|amod|END_ENTITY	Effects of the 5-HT1A_receptor agonist flesinoxan in panic_disorder .
9163561	0	flesinoxan	115,125	5-HT1A_receptor	13,28	flesinoxan	5-HT1A receptor	MESH:C056895	3350	Chemical	Gene	stimulus|nmod|START_ENTITY blocks|dobj|stimulus blocks|nsubj|DU125530 DU125530|amod|END_ENTITY	The putative 5-HT1A_receptor antagonist DU125530 blocks the discriminative stimulus of the 5-HT1A_receptor agonist flesinoxan in pigeons .
9548383	0	flesinoxan	22,32	5-HT1A_receptor	103,118	flesinoxan	5-HT1A receptor	MESH:C056895	15550(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY mediated|nsubj|effects mediated|amod|END_ENTITY	Anxiolytic effects of flesinoxan in the stress-induced hyperthermia paradigm in singly-housed mice are 5-HT1A_receptor mediated .
7915872	0	flezelastine	11,23	IL-1_beta	59,68	flezelastine	IL-1 beta	MESH:C089205	24494(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|generation generation|compound|END_ENTITY	Effects of flezelastine and its enantiomers on LPS-induced IL-1_beta generation in vitro and LPS-induced pyrexia in vivo .
11321358	0	flosulide	77,86	cyclooxygenase-2	39,55	flosulide	cyclooxygenase-2	MESH:C059178	29527(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Acute effects of the anti-inflammatory cyclooxygenase-2 selective inhibitor , flosulide , on renal plasma flow and glomerular filtration rate in rats .
10571785	0	flosulide	10,19	cyclooxygenase_2	33,49	flosulide	cyclooxygenase 2	MESH:C059178	29527(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effect of flosulide , a selective cyclooxygenase_2 inhibitor , on passive heymann_nephritis in the rat .
9736824	0	flosulide	62,71	cyclooxygenase_2	25,41	flosulide	cyclooxygenase 2	MESH:C059178	29527(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|actions actions|nmod|inhibitor inhibitor|amod|END_ENTITY	Different actions of the cyclooxygenase_2 selective inhibitor flosulide in rats with passive Heymann_nephritis .
11710597	0	floxuridine	46,57	P53	0,3	floxuridine	P53	MESH:D005467	7157	Chemical	Gene	START_ENTITY|nsubj|mutation mutation|compound|END_ENTITY	P53 mutation and response to hepatic arterial floxuridine in patients with colorectal_liver_metastases .
16428784	0	fluconazole	75,86	AFR1	8,12	fluconazole	AFR1	MESH:D015725	387609(Tax:10090)	Chemical	Gene	response|nmod|START_ENTITY Role|nmod|response Role|nmod|END_ENTITY	Role of AFR1 , an ABC transporter-encoding gene , in the in vivo response to fluconazole and virulence of Cryptococcus_neoformans .
21545485	0	fluconazole	42,53	CYP3A4	24,30	fluconazole	CYP3A4	MESH:D015725	1576	Chemical	Gene	Effects|amod|START_ENTITY Effects|nmod|END_ENTITY	Effects of the moderate CYP3A4 inhibitor , fluconazole , on the pharmacokinetics of fesoterodine in healthy subjects .
23216650	0	fluconazole	69,80	ERG11	58,63	fluconazole	ERG11	MESH:D015725	856398(Tax:4932)	Chemical	Gene	resistance|amod|START_ENTITY END_ENTITY|nmod|resistance	Association of T916C -LRB- Y257H -RRB- mutation in Candida_albicans ERG11 with fluconazole resistance .
25062749	0	fluconazole	74,85	Pdr5p	59,64	fluconazole	Pdr5p	MESH:D015725	854324(Tax:4932)	Chemical	Gene	resistance|compound|START_ENTITY resistance|amod|END_ENTITY	Synthetic organotelluride compounds induce the reversal of Pdr5p mediated fluconazole resistance in Saccharomyces_cerevisiae .
25445311	0	fluconazole	52,63	Yap1	24,28	fluconazole	Yap1	MESH:D015725	855005(Tax:4932)	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Cryptococcus_neoformans Yap1 is required for normal fluconazole and oxidative stress resistance .
7769317	0	fluconazole	135,146	interleukin-1_beta	32,50	fluconazole	interleukin-1 beta	MESH:D015725	3553	Chemical	Gene	therapy|nmod|START_ENTITY END_ENTITY|nmod|therapy	Tumor_necrosis_factor-alpha and interleukin-1_beta in cerebrospinal fluid of patients with coccidioidal_meningitis during therapy with fluconazole .
22308293	0	fludarabine	36,47	BIRC3	14,19	fludarabine	BIRC3	MESH:C024352	330	Chemical	Gene	associates|nmod|START_ENTITY associates|nummod|END_ENTITY	Disruption of BIRC3 associates with fludarabine chemorefractoriness in TP53 wild-type chronic_lymphocytic_leukemia .
10674897	0	fludarabine	57,68	CD40	0,4	fludarabine	CD40	MESH:C024352	958	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	CD40 and B chronic_lymphocytic_leukemia cell response to fludarabine : the influence of NF-kappaB/Rel transcription factors on chemotherapy-induced apoptosis .
16533725	0	fludarabine	14,25	interferon-gamma	29,45	fludarabine	interferon-gamma	MESH:C024352	3458	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|production production|amod|END_ENTITY	The effect of fludarabine on interferon-gamma production by lymphoid cells from healthy donors and patients with B-cell_chronic_lymphocytic_leukemia .
14623330	0	fludarabine	81,92	p53	15,18	fludarabine	p53	MESH:C024352	7157	Chemical	Gene	Involvement|acl|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of p53 in alpha4beta1 integrin-mediated resistance of B-CLL cells to fludarabine .
23052036	0	fludioxonil	21,32	miR-21	58,64	fludioxonil	miR-21	MESH:C108339	406991	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Endocrine disruptors fludioxonil and fenhexamid_stimulate miR-21 expression in breast_cancer cells .
22559244	0	fludrocortisone	64,79	Endothelin-1	0,12	fludrocortisone	Endothelin-1	MESH:D005438	1906	Chemical	Gene	levels|acl|START_ENTITY levels|amod|END_ENTITY	Endothelin-1 and adrenomedullin plasma levels after exposure to fludrocortisone , dexamethasone , and spironolactone .
6919568	0	fludrocortisone	54,69	kallikrein	90,100	fludrocortisone	kallikrein	MESH:D005438	9622	Chemical	Gene	Effects|nmod|START_ENTITY Effects|acl|END_ENTITY	Effects of restriction of sodium or administration of fludrocortisone on parotid salivary kallikrein in man .
24370036	0	flumatinib_mesylate	11,30	C-MYC	34,39	flumatinib mesylate	C-MYC	null	4609	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of flumatinib_mesylate on C-MYC , HIF-1a and VEGF in U226 line -RSB- .
1288050	0	flumecinol	10,20	cytochrome_P450	38,53	flumecinol	cytochrome P450	MESH:C016914	25251(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of flumecinol -LRB- Zixoryn -RRB- on the cytochrome_P450 and cytochrome_P448 dependent hepatic microsomal monooxygenase activities in male rats .
7954746	0	flunarizine	57,68	Dopamine_D2_receptor	0,20	flunarizine	Dopamine D2 receptor	MESH:D005444	1813	Chemical	Gene	blockade|nmod|START_ENTITY blockade|amod|END_ENTITY	Dopamine_D2_receptor blockade and antimigraine action of flunarizine .
9088653	0	flunisolide	42,53	eosinophil_cationic_protein	89,116	flunisolide	eosinophil cationic protein	MESH:C007734	6037	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Allergic_rhinitis in children : effects of flunisolide and disodium_cromoglycate on nasal eosinophil_cationic_protein .
14705899	0	flunixin-N-methyl_glucamine	50,77	milk	88,92	flunixin-N-methyl glucamine	milk	null	100532204	Chemical	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	Residue depletion study and withdrawal period for flunixin-N-methyl_glucamine in bovine milk following intravenous administration .
16454812	0	fluocinolone_acetonide	59,81	TNF-alpha	14,23	fluocinolone acetonide	TNF-alpha	MESH:D005446	7124	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|Expression Expression|nmod|END_ENTITY	Expression of TNF-alpha in oral lichen planus treated with fluocinolone_acetonide 0.1 % .
20933415	0	fluorene_thiosemicarbazone	54,80	cathepsin_L	110,121	fluorene thiosemicarbazone	cathepsin L	null	1514	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Functionalized benzophenone , thiophene , pyridine , and fluorene_thiosemicarbazone derivatives as inhibitors of cathepsin_L .
17228735	0	fluorescein	71,82	albumin	100,107	fluorescein	albumin	MESH:D019793	213	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Fluorescence spectra and test application study on the interaction of fluorescein and bovine serum albumin -RSB- .
16838159	0	fluorescein	60,71	beta-galactosidase	75,93	fluorescein	beta-galactosidase	MESH:D019793	2720	Chemical	Gene	kinetics|nmod|START_ENTITY kinetics|nmod|END_ENTITY	Measurement of hydrolysis kinetics of galactose-substituted fluorescein by beta-galactosidase at the toluene-water interface by spinning microtube fluorometry .
6528543	0	fluorescein_bimercuric_acetate	21,51	histidine_decarboxylase	55,78	fluorescein bimercuric acetate	histidine decarboxylase	null	3067	Chemical	Gene	binding|nmod|START_ENTITY binding|nmod|END_ENTITY	-LSB- Specific binding of fluorescein_bimercuric_acetate by histidine_decarboxylase from Micrococcus -RSB- .
21540359	0	fluorescein_diacetate	57,78	carboxylesterase_2	110,128	fluorescein diacetate	carboxylesterase 2	MESH:C018506	8824	Chemical	Gene	START_ENTITY|nmod|substrate substrate|nmod|END_ENTITY	Characterization of recombinant human carboxylesterases : fluorescein_diacetate as a probe substrate for human carboxylesterase_2 .
2938353	0	fluorescein_isothiocyanate	12,38	ATPase	83,89	fluorescein isothiocyanate	ATPase	CHEBI:37926	1769	Chemical	Gene	Reaction|nmod|START_ENTITY Reaction|nmod|END_ENTITY	Reaction of fluorescein_isothiocyanate with thiol and amino groups of sarcoplasmic ATPase .
6405789	0	fluorescein_isothiocyanate	38,64	cytochrome_P-450	16,32	fluorescein isothiocyanate	cytochrome P-450	CHEBI:37926	4051	Chemical	Gene	Modification|nmod|START_ENTITY Modification|nmod|END_ENTITY	Modification of cytochrome_P-450 with fluorescein_isothiocyanate .
25183529	0	fluoride	10,18	Foxo1	27,32	fluoride	Foxo1	MESH:D005459	84482(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|amod|END_ENTITY	Excessive fluoride reduces Foxo1 expression in dental epithelial cells of the rat incisor .
21565259	0	fluoride	82,90	JNK	130,133	fluoride	JNK	MESH:D005459	5599	Chemical	Gene	START_ENTITY|dep|mechanism mechanism|acl|connected connected|advcl|activating activating|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Increased level of apoptosis in rat brains and SH-SY5Y cells exposed to excessive fluoride -- a mechanism connected with activating JNK phosphorylation .
21451891	0	fluoride	11,19	MMP-20	41,47	fluoride	MMP-20	MESH:D005459	300341(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of fluoride on the expression of MMP-20 / TIMP-2 in ameloblast of rat incisor and the antagonistic effect of melatonin against fluorosis -RSB- .
17537562	0	fluoride	11,19	NCAM	41,45	fluoride	NCAM	MESH:D005459	24586(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of fluoride on the expression of NCAM , oxidative stress , and apoptosis in primary cultured hippocampal neurons .
11441488	0	fluoride	65,73	NaF	35,38	fluoride	NaF	MESH:D005459	3576	Chemical	Gene	ion|compound|START_ENTITY Effects|nmod|ion Effects|nmod|END_ENTITY	Effects of polysiloxane coating of NaF on the release profile of fluoride ion from Bis-GMA/TEGDMA resin containing NaF .
12147166	0	fluoride	7,15	NaF	64,67	fluoride	NaF	MESH:D005459	3576	Chemical	Gene	uptake|nsubj|START_ENTITY uptake|nmod|concentrations concentrations|compound|END_ENTITY	Enamel fluoride uptake from mouthrinse solutions with different NaF concentrations .
7537442	0	fluoride	57,65	PLA2	34,38	fluoride	PLA2	MESH:D005459	18784(Tax:10090)	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	On the mechanism of activation of PLA2 and PtdIns-PLC by fluoride in murine macrophages .
21560300	0	fluoride	20,28	Runx2	63,68	fluoride	Runx2	MESH:D005459	12393(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Combined effect of fluoride and aluminum on the expression of Runx2 and Osterix mRNA in MC3T3-E1 cells -RSB- .
22443068	0	fluoride	11,19	StAR	41,45	fluoride	StAR	MESH:D005459	20845(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|mRNA mRNA|compound|END_ENTITY	-LSB- Effect of fluoride on the expression of StAR mRNA and P450scc mRNA in the progesterone synthesis of mouse Leydig_tumor cells -RSB- .
26774298	0	fluoride	11,19	StAR	51,55	fluoride	StAR	MESH:D005459	100732626	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of fluoride and aluminum on expressions of StAR and P450scc of related steroidogenesis in guinea_pigs ' testis .
21451891	0	fluoride	11,19	TIMP-2	48,54	fluoride	TIMP-2	MESH:D005459	29543(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|END_ENTITY	-LSB- Effect of fluoride on the expression of MMP-20 / TIMP-2 in ameloblast of rat incisor and the antagonistic effect of melatonin against fluorosis -RSB- .
26232646	0	fluoride	11,19	Tuba1a	68,74	fluoride	Tuba1a	MESH:D005459	22142(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of fluoride on microtubule ultrastructure and expression of Tuba1a and Tubb2a in mouse hippocampus .
26232646	0	fluoride	11,19	Tuba1a	68,74	fluoride	Tuba1a	MESH:D005459	22142(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of fluoride on microtubule ultrastructure and expression of Tuba1a and Tubb2a in mouse hippocampus .
15842830	0	fluoride	58,66	bcl-2	49,54	fluoride	bcl-2	MESH:D005459	596	Chemical	Gene	-RSB-|compound|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- Differential expression of osteopontin and bax , bcl-2 by fluoride -RSB- .
11860940	0	fluoride	12,20	c-fos	42,47	fluoride	c-fos	MESH:D005459	314322(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|genes genes|amod|END_ENTITY	-LSB- Effects of fluoride on the expression of c-fos and c-jun genes and cell proliferation of rat osteoblasts -RSB- .
2098711	0	fluoride	13,21	catalase	36,44	fluoride	catalase	MESH:D005459	531682(Tax:9913)	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|activity activity|amod|END_ENTITY	pH-dependent fluoride inhibition of catalase activity .
18399128	0	fluoride	12,20	neural_cell_adhesion_molecules	24,54	fluoride	neural cell adhesion molecules	MESH:D005459	24586(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|mRNA mRNA|amod|END_ENTITY	-LSB- Effects of fluoride on neural_cell_adhesion_molecules mRNA and protein expression levels in primary rat hippocampal neurons -RSB- .
707138	0	fluoride	10,18	ornithine_decarboxylase	38,61	fluoride	ornithine decarboxylase	MESH:D005459	4953	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|nmod|END_ENTITY	Effect of fluoride on the activity of ornithine_decarboxylase in normal and fluoride resistant LS cells .
17190191	0	fluoride	19,27	osteoclast_differentiation_factor	63,96	fluoride	osteoclast differentiation factor	MESH:D005459	117516(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Combined effect of fluoride and arsenate on gene expression of osteoclast_differentiation_factor and osteoprotegerin .
21739163	0	fluoride	31,39	osteoprotegerin	144,159	fluoride	osteoprotegerin	MESH:D005459	18383(Tax:10090)	Chemical	Gene	administration|nmod|START_ENTITY regulates|nsubj|administration regulates|advcl|altering altering|dobj|END_ENTITY	Simultaneous administration of fluoride and selenite regulates proliferation and apoptosis in murine osteoblast-like MC3T3-E1 cells by altering osteoprotegerin .
23456427	0	fluoride	10,18	osteoprotegerin	87,102	fluoride	osteoprotegerin	MESH:D005459	25341(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of fluoride and low versus high levels of dietary calcium on mRNA expression of osteoprotegerin and osteoprotegerin_ligand in the bone of rats .
15461257	0	fluoride	75,83	p53	41,44	fluoride	p53	MESH:D005459	7157	Chemical	Gene	induced|nmod|START_ENTITY expression|acl|induced expression|compound|END_ENTITY	-LSB- Effects on DNA damage and apoptosis and p53 protein expression induced by fluoride in human embryo hepatocytes -RSB- .
15950406	0	fluoride	64,72	p53	49,52	fluoride	p53	MESH:D005459	7157	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Effects Effects|nmod|END_ENTITY	Effects on protein and mRNA expression levels of p53 induced by fluoride in human embryonic hepatocytes .
2463739	0	fluoride	11,19	parathyroid_hormone	23,42	fluoride	parathyroid hormone	MESH:D005459	280903(Tax:9913)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|amod|END_ENTITY	Effects of fluoride on parathyroid_hormone secretion and intracellular second messengers in bovine parathyroid cells .
16434764	0	fluoride	47,55	pseudocholinesterase	70,90	fluoride	pseudocholinesterase	MESH:D005459	590	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	Temperature , the benzoylcholine substrate , and fluoride inhibition of pseudocholinesterase .
23654100	0	fluoride	20,28	sex_hormone_binding_globulin	41,69	fluoride	sex hormone binding globulin	MESH:D005459	6462	Chemical	Gene	exposure|compound|START_ENTITY exposure|nmod|END_ENTITY	-LSB- Influence of water fluoride exposure on sex_hormone_binding_globulin and testosterone in adult male -RSB- .
17456401	0	fluoride	11,19	telomerase_reverse_transcriptase	37,69	fluoride	telomerase reverse transcriptase	MESH:D005459	301965(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	-LSB- Effect of fluoride on expression of telomerase_reverse_transcriptase expression and proliferating_cell_nuclear_antigen in germ cells of rats ' testes -RSB- .
19203623	0	fluoride	73,81	tyrosinase	51,61	fluoride	tyrosinase	MESH:D005459	7299	Chemical	Gene	determination|compound|START_ENTITY enzyme|nmod|determination enzyme|amod|END_ENTITY	An inhibition type amperometric biosensor based on tyrosinase enzyme for fluoride determination .
24520856	0	fluorinated_tetrahydrouridine	53,82	cytidine_deaminase	112,130	fluorinated tetrahydrouridine	cytidine deaminase	null	705913(Tax:9544)	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|inhibitors inhibitors|nmod|END_ENTITY	Design , synthesis , and pharmacological evaluation of fluorinated_tetrahydrouridine derivatives as inhibitors of cytidine_deaminase .
1323952	0	fluorine	115,123	C-8	111,114	fluorine	C-8	MESH:D005461	3224	Chemical	Gene	group|compound|START_ENTITY group|compound|END_ENTITY	Effects of novel fluoroquinolones on the catalytic activities of eukaryotic topoisomerase_II : Influence of the C-8 fluorine group .
21033444	0	fluorine	14,22	androgen-binding_protein	40,64	fluorine	androgen-binding protein	MESH:D005461	24775(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|mRNA mRNA|compound|END_ENTITY	-LSB- Influence of fluorine on expression of androgen-binding_protein and inhibin B mRNA in rat testis sertoli cells -RSB- .
1880575	0	fluorine-18-fluorocaptopril	64,91	angiotensin-converting_enzyme	17,46	fluorine-18-fluorocaptopril	angiotensin-converting enzyme	null	24310(Tax:10116)	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|END_ENTITY	Positron-labeled angiotensin-converting_enzyme -LRB- ACE -RRB- inhibitor : fluorine-18-fluorocaptopril .
17684619	0	fluorine-18_fluordeoxyglucose	75,104	thyroglobulin	167,180	fluorine-18 fluordeoxyglucose	thyroglobulin	null	7038	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|levels levels|compound|END_ENTITY	-LSB- Diagnostic value of positron emission tomography/computed tomography with fluorine-18_fluordeoxyglucose in patients with differentiated_thyroid_gland_carcinoma , high thyroglobulin serum levels and negative iodine whole_body_scan -RSB- .
10990851	0	fluorite	190,198	CaF2	68,72	fluorite	CaF2	CHEBI:35437	9337	Chemical	Gene	dynamics|nmod|START_ENTITY dynamics|nmod|END_ENTITY	Coherent dynamics of the localized vibrational modes of hydrogen in CaF2 We report the observation of giant quantum coherence effects in the localized modes of ionized hydrogen in synthetic fluorite .
15130777	0	fluoro	78,84	albumin	59,66	fluoro	albumin	CHEBI:42645	213	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Molten-globule like partially folded states of human serum albumin induced by fluoro and alkyl_alcohols at low pH. Human serum_albumin _ -LRB- HSA -RRB- exists in a molten-globule like state at low pH -LRB- pH 2.0 -RRB- .
17059174	0	fluorobenzaldehydes	22,41	tyrosinase	70,80	fluorobenzaldehydes	tyrosinase	null	7299	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nsubj|effects	Inhibitory effects of fluorobenzaldehydes on the activity of mushroom tyrosinase .
12138656	0	fluorodeoxyglucose	15,33	F-18	10,14	fluorodeoxyglucose	F-18	null	10046	Chemical	Gene	START_ENTITY|nsubj|Value Value|nmod|END_ENTITY	-LSB- Value of F-18 fluorodeoxyglucose positron emission tomography in thyroid_carcinoma -RSB- .
12475827	0	fluorodeoxyglucose	22,40	F-18	17,21	fluorodeoxyglucose	F-18	null	10046	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	Clinical role of F-18 fluorodeoxyglucose positron emission tomography imaging in patients with lung_cancer and suspected malignant_pleural_effusion .
20026963	0	fluorodeoxyglucose	29,47	F-18	24,28	fluorodeoxyglucose	F-18	null	10046	Chemical	Gene	uptake|compound|START_ENTITY uptake|compound|END_ENTITY	The prognostic value of F-18 fluorodeoxyglucose bone marrow uptake in patients with recent diagnosis of multiple_myeloma : a comparative study with Tc-99m sestamibi .
20108309	0	fluorodeoxyglucose	23,41	F-18	18,22	fluorodeoxyglucose	F-18	null	10046	Chemical	Gene	uptake|compound|START_ENTITY uptake|compound|END_ENTITY	Pelvic lymph node F-18 fluorodeoxyglucose uptake as a prognostic biomarker in newly diagnosed patients with locally advanced cervical_cancer .
20231040	0	fluorodeoxyglucose	25,43	F-18	20,24	fluorodeoxyglucose	F-18	null	10046	Chemical	Gene	uptake|compound|START_ENTITY uptake|compound|END_ENTITY	Anal_cancer maximum F-18 fluorodeoxyglucose uptake on positron emission tomography is correlated with prognosis .
9072107	0	fluorodeoxyglucose	89,107	F-18	84,88	fluorodeoxyglucose	F-18	null	10046	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Metabolic characterization of ovarian_tumors with positron-emission tomography and F-18 fluorodeoxyglucose -RSB- .
1385949	0	fluorodeoxyuridine	132,150	thymidylate_synthase	108,128	fluorodeoxyuridine	thymidylate synthase	MESH:D005467	22171(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nmod|suppression suppression|nmod|END_ENTITY	Interconversion of tetrahydrofolate cofactors to dihydrofolate induced by trimetrexate after suppression of thymidylate_synthase by fluorodeoxyuridine in L1210 leukemia cells .
8133902	0	fluorodopa	34,44	COMT	0,4	fluorodopa	COMT	null	1312	Chemical	Gene	inhibitors|nmod|START_ENTITY inhibitors|compound|END_ENTITY	COMT inhibitors and metabolism of fluorodopa enantiomers in aggregating cell cultures .
2656298	0	fluoroketones	4,17	renin	27,32	fluoroketones	renin	null	5972	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	New fluoroketones as human renin inhibitors .
22617491	0	fluoromethyl_ketone	94,113	ubiquitin_carboxy-terminal_hydrolase_L1	28,67	fluoromethyl ketone	ubiquitin carboxy-terminal hydrolase L1	null	7345	Chemical	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	The co-crystal structure of ubiquitin_carboxy-terminal_hydrolase_L1 -LRB- UCHL1 -RRB- with a tripeptide fluoromethyl_ketone -LRB- Z-VAE -LRB- OMe -RRB- - FMK -RRB- .
4073501	0	fluoromethyl_ketones	21,41	cathepsin_B	70,81	fluoromethyl ketones	cathepsin B	null	1508	Chemical	Gene	Synthesis|nmod|START_ENTITY Synthesis|nmod|END_ENTITY	Synthesis of peptide fluoromethyl_ketones and the inhibition of human cathepsin_B .
20034789	0	fluorophosphonates	57,75	acetylcholinesterase	14,34	fluorophosphonates	acetylcholinesterase	null	11423(Tax:10090)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of acetylcholinesterase by chromophore-linked fluorophosphonates .
22235991	0	fluoropyrimidine	25,41	S-1	0,3	fluoropyrimidine	S-1	null	5707	Chemical	Gene	agent|compound|START_ENTITY END_ENTITY|nmod|agent	S-1 as a core anticancer fluoropyrimidine agent .
15949589	0	fluoropyrimidine	51,67	dihydropyrimidine_dehydrogenase	8,39	fluoropyrimidine	dihydropyrimidine dehydrogenase	null	1806	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of dihydropyrimidine_dehydrogenase inhibitory fluoropyrimidine against non-small_cell_lung_cancer -- in correlation with the tumoral expression of thymidylate synthase and dihydropyrimidine_dehydrogenase .
12530071	0	fluoropyrimidine	90,106	thymidylate_synthetase	31,53	fluoropyrimidine	thymidylate synthetase	null	7298	Chemical	Gene	role|nmod|START_ENTITY role|nmod|inhibition inhibition|amod|END_ENTITY	A potential important role for thymidylate_synthetase inhibition on antitumor activity of fluoropyrimidine and raltitexed .
12775023	0	fluoropyrimidines	101,118	DPD	86,89	fluoropyrimidines	DPD	null	1806	Chemical	Gene	START_ENTITY|nsubj|activity activity|nmod|END_ENTITY	Dihydropyrimidine_dehydrogenase -LRB- DPD -RRB- activity in gastric_cancer tissue and effect of DPD inhibitory fluoropyrimidines .
12775023	0	fluoropyrimidines	101,118	Dihydropyrimidine_dehydrogenase	0,31	fluoropyrimidines	Dihydropyrimidine dehydrogenase	null	1806	Chemical	Gene	START_ENTITY|nsubj|activity activity|amod|END_ENTITY	Dihydropyrimidine_dehydrogenase -LRB- DPD -RRB- activity in gastric_cancer tissue and effect of DPD inhibitory fluoropyrimidines .
24452393	0	fluoropyrimidines	107,124	dUTPase	128,135	fluoropyrimidines	dUTPase	null	34529(Tax:7227)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	First-in-human , phase I dose-escalation study of single and multiple doses of a first-in-class enhancer of fluoropyrimidines , a dUTPase inhibitor -LRB- TAS-114 -RRB- in healthy male volunteers .
7872757	0	fluoroquinolone	29,44	CP-99	45,50	fluoroquinolone	CP-99	null	13917311	Chemical	Gene	activity|nmod|START_ENTITY END_ENTITY|nsubj|activity	In vitro activity of the new fluoroquinolone CP-99 ,219 .
2843082	0	fluoroquinolone	63,78	T-3262	49,55	fluoroquinolone	T-3262	null	1068506(Tax:209261)	Chemical	Gene	START_ENTITY|nmod|activities activities|nmod|END_ENTITY	In vitro and in vivo antibacterial activities of T-3262 , a new fluoroquinolone .
1332594	0	fluoroquinolone	35,50	T-3761	21,27	fluoroquinolone	T-3761	null	1069285(Tax:209261)	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	In vitro activity of T-3761 , a new fluoroquinolone .
9635499	0	fluoroquinolone	50,65	T-3762	34,40	fluoroquinolone	T-3762	null	1069284(Tax:209261)	Chemical	Gene	START_ENTITY|nsubj|properties properties|nmod|END_ENTITY	Histamine-releasing properties of T-3762 , a novel fluoroquinolone antimicrobial agent in intravenous use .
9635500	0	fluoroquinolone	50,65	T-3762	34,40	fluoroquinolone	T-3762	null	1069284(Tax:209261)	Chemical	Gene	START_ENTITY|nsubj|properties properties|nmod|END_ENTITY	Histamine-releasing properties of T-3762 , a novel fluoroquinolone antimicrobial agent in intravenous use .
9781839	0	fluoroquinolone	46,61	T-3762	30,36	fluoroquinolone	T-3762	null	1069284(Tax:209261)	Chemical	Gene	START_ENTITY|nsubj|properties properties|nmod|END_ENTITY	Pharmacological properties of T-3762 , a novel fluoroquinolone antimicrobial agent in parenteral use .
25141348	0	fluoroquinolone	85,100	extended-spectrum_b-lactamase	34,63	fluoroquinolone	extended-spectrum b-lactamase	null	13906541	Chemical	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Prevalence and characteristics of extended-spectrum_b-lactamase and plasmid-mediated fluoroquinolone resistance genes in Escherichia_coli isolated from chickens in Anhui province , China .
16127038	0	fluoroquinolone	83,98	granulocyte_colony-stimulating_factor	29,66	fluoroquinolone	granulocyte colony-stimulating factor	null	12985(Tax:10090)	Chemical	Gene	therapy|amod|START_ENTITY END_ENTITY|nmod|therapy	Effect of recombinant murine granulocyte_colony-stimulating_factor with or without fluoroquinolone therapy on mixed-infection_abscesses in mice .
19717263	0	fluoroquinolone	17,32	qepA	51,55	fluoroquinolone	qepA	null	6275948(Tax:526563)	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Plasmid-mediated fluoroquinolone efflux pump gene , qepA , in Escherichia_coli clinical isolates in Korea .
1323952	0	fluoroquinolones	17,33	topoisomerase_II	76,92	fluoroquinolones	topoisomerase II	MESH:D024841	35225(Tax:7227)	Chemical	Gene	START_ENTITY|nmod|activities activities|nmod|END_ENTITY	Effects of novel fluoroquinolones on the catalytic activities of eukaryotic topoisomerase_II : Influence of the C-8 fluorine group .
25873402	0	fluorouracil	46,58	DPYD	81,85	fluorouracil	DPYD	MESH:D005472	1806	Chemical	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	MicroRNA-494 sensitizes colon_cancer cells to fluorouracil through regulation of DPYD .
25873402	0	fluorouracil	46,58	DPYD	81,85	fluorouracil	DPYD	MESH:D005472	1806	Chemical	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	MicroRNA-494 sensitizes colon_cancer cells to fluorouracil through regulation of DPYD .
27091477	0	fluorouracil	48,60	Epidermal_growth_factor_receptor	0,32	fluorouracil	Epidermal growth factor receptor	MESH:D005472	1956	Chemical	Gene	inhibitor|nmod|START_ENTITY inhibitor|nsubj|END_ENTITY	Epidermal_growth_factor_receptor inhibitor with fluorouracil , leucovorin , and irinotecan as an alternative treatment for advanced upper_tract_urothelial_carcinoma : a case report .
7595716	0	fluorouracil	127,139	granulocyte-macrophage_colony-stimulating_factor	10,58	fluorouracil	granulocyte-macrophage colony-stimulating factor	MESH:D005472	1437	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of granulocyte-macrophage_colony-stimulating_factor on oral_mucositis in head_and_neck cancer patients after cisplatin , fluorouracil , and leucovorin chemotherapy .
8120554	0	fluorouracil	130,142	granulocyte-macrophage_colony-stimulating_factor	55,103	fluorouracil	granulocyte-macrophage colony-stimulating factor	MESH:D005472	1437	Chemical	Gene	leucovorin|compound|START_ENTITY given|nmod|leucovorin given|nsubj|I I|nmod|END_ENTITY	Phase I and pharmacokinetic study of recombinant human granulocyte-macrophage_colony-stimulating_factor given in combination with fluorouracil plus calcium leucovorin in metastatic gastrointestinal_adenocarcinoma .
9667271	0	fluorouracil	108,120	interleukin-2	39,52	fluorouracil	interleukin-2	MESH:D005472	3558	Chemical	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	Outpatient treatment with subcutaneous interleukin-2 and interferon alfa administration in combination with fluorouracil in patients with metastatic_renal_cell_carcinoma : results of a sequential nonrandomized phase II study .
1532671	0	fluorouracil	26,38	thymidylate_synthase	66,86	fluorouracil	thymidylate synthase	MESH:D005472	22171(Tax:10090)	Chemical	Gene	activity|amod|START_ENTITY Effect|nmod|activity Effect|nmod|END_ENTITY	Effect of folinic_acid on fluorouracil activity and expression of thymidylate_synthase .
674296	0	fluostigmine	107,119	acetylcholinesterase	83,103	fluostigmine	acetylcholinesterase	MESH:D007531	43	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Protective effects of a series of new pyridinium derivatives against inhibition of acetylcholinesterase by fluostigmine .
15380370	0	fluoxetine	78,88	5-HT1A	92,98	fluoxetine	5-HT1A	MESH:D005473	24473(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|receptors receptors|nummod|END_ENTITY	Differential effects of the novel antidepressant agomelatine -LRB- S_20098 -RRB- versus fluoxetine on 5-HT1A receptors in the rat brain .
8148368	0	fluoxetine	35,45	5-HT1A	89,95	fluoxetine	5-HT1A	MESH:D005473	24473(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|receptors receptors|compound|END_ENTITY	Effects of repeated treatment with fluoxetine and citalopram , 5-HT uptake inhibitors , on 5-HT1A and 5-HT2 receptors in the rat brain .
25914158	0	fluoxetine	77,87	5-HT2A	0,6	fluoxetine	5-HT2A	MESH:D005473	15558(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY involved|nmod|effects involved|nsubjpass|receptors receptors|nummod|END_ENTITY	5-HT2A receptors are involved in cognitive but not antidepressant effects of fluoxetine .
18923397	0	fluoxetine	53,63	AQP4	15,19	fluoxetine	AQP4	MESH:D005473	11829(Tax:10090)	Chemical	Gene	efficiency|nmod|START_ENTITY END_ENTITY|nmod|efficiency	Requirement of AQP4 for antidepressive efficiency of fluoxetine : implication in adult hippocampal neurogenesis .
26531387	0	fluoxetine	32,42	AQP4	24,28	fluoxetine	AQP4	MESH:D005473	11829(Tax:10090)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Different regulation of AQP4 by fluoxetine in normal and CMS model mice .
16035958	0	fluoxetine	23,33	BDNF	56,60	fluoxetine	BDNF	MESH:D005473	24225(Tax:10116)	Chemical	Gene	treatment|nmod|START_ENTITY up-regulates|nsubj|treatment up-regulates|dobj|expression expression|amod|END_ENTITY	Chronic treatment with fluoxetine up-regulates cellular BDNF mRNA expression in rat dopaminergic regions .
17328894	0	fluoxetine	11,21	BDNF	59,63	fluoxetine	BDNF	MESH:D005473	627	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of fluoxetine on ischemic cells and expressions in BDNF and some antioxidants in the gerbil hippocampal CA1 region induced by transient ischemia .
18977602	0	fluoxetine	8,18	BDNF	125,129	fluoxetine	BDNF	MESH:D005473	24225(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|dep|role role|nmod|signalling signalling|compound|END_ENTITY	Chronic fluoxetine treatment increases expression of synaptic proteins in the hippocampus of the ovariectomized rat : role of BDNF signalling .
20196181	0	fluoxetine	156,166	BDNF	15,19	fluoxetine	BDNF	MESH:D005473	627	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|Association Association|nmod|polymorphism polymorphism|compound|END_ENTITY	Association of BDNF Val66Met polymorphism with both baseline HRQOL scores and improvement in HRQOL scores in Chinese major depressive patients treated with fluoxetine .
21048974	0	fluoxetine	134,144	BDNF	13,17	fluoxetine	BDNF	MESH:D005473	24225(Tax:10116)	Chemical	Gene	gyrus|nmod|START_ENTITY gyrus|nsubj|roles roles|nmod|END_ENTITY	The roles of BDNF , pCREB and Wnt3a in the latent period preceding activation of progenitor cell mitosis in the adult dentate gyrus by fluoxetine .
24974462	0	fluoxetine	11,21	BDNF	44,48	fluoxetine	BDNF	MESH:D005473	12064(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expressions expressions|nmod|END_ENTITY	-LSB- Effect of fluoxetine on the expressions of BDNF and Bcl-2 during fear memory formation -RSB- .
26514447	0	fluoxetine	138,148	BDNF	70,74	fluoxetine	BDNF	MESH:D005473	627	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|Comparison Comparison|nmod|levels levels|appos|END_ENTITY	Comparison of efficacy , safety and brain_derived_neurotrophic_factor -LRB- BDNF -RRB- levels in patients of major_depressive_disorder , treated with fluoxetine and desvenlafaxine .
26608001	0	fluoxetine	43,53	BDNF	103,107	fluoxetine	BDNF	MESH:D005473	627	Chemical	Gene	stress|nmod|START_ENTITY have|nsubj|stress have|dobj|effects effects|nmod|expression expression|compound|END_ENTITY	Prenatal stress and early-life exposure to fluoxetine have enduring effects on anxiety and hippocampal BDNF gene expression in adult male offspring .
21619414	0	fluoxetine	49,59	BMPR2	15,20	fluoxetine	BMPR2	MESH:D005473	140590(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY Involvement|nmod|effect Involvement|nmod|END_ENTITY	Involvement of BMPR2 in the protective effect of fluoxetine against monocrotaline-induced endothelial apoptosis in rats .
21740920	0	fluoxetine	87,97	Bcl-xL	43,49	fluoxetine	Bcl-xL	MESH:D005473	24888(Tax:10116)	Chemical	Gene	treated|nmod|START_ENTITY rats|acl|treated expression|nmod|rats expression|compound|END_ENTITY	Stress-induced activation of the brainstem Bcl-xL gene expression in rats treated with fluoxetine : correlations with serotonin metabolism and depressive-like behavior .
21701640	0	fluoxetine	11,21	C-reactive_protein	42,60	fluoxetine	C-reactive protein	MESH:D005473	1401	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of fluoxetine and escitalopram on C-reactive_protein in patients of depression .
12482470	0	fluoxetine	24,34	CREB	101,105	fluoxetine	CREB	MESH:D005473	1385	Chemical	Gene	effects|nmod|START_ENTITY effects|amod|END_ENTITY	Differential effects of fluoxetine and imipramine on the phosphorylation of the transcription factor CREB and cell-viability .
11453896	0	fluoxetine	48,58	CYP2C19	14,21	fluoxetine	CYP2C19	MESH:D005473	1557	Chemical	Gene	metabolism|amod|START_ENTITY polymorphism|nmod|metabolism polymorphism|nsubj|Effect Effect|nmod|oxidation oxidation|compound|END_ENTITY	Effect of the CYP2C19 oxidation polymorphism on fluoxetine metabolism in Chinese healthy subjects .
11752104	0	fluoxetine	18,28	CYP2C19	44,51	fluoxetine	CYP2C19	MESH:D005473	1557	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	O-Dealkylation of fluoxetine in relation to CYP2C19 gene dose and involvement of CYP3A4 in human liver microsomes .
23785064	0	fluoxetine	52,62	CYP2C19	30,37	fluoxetine	CYP2C19	MESH:D005473	1557	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Stereoselective inhibition of CYP2C19 and CYP3A4 by fluoxetine and its metabolite : implications for risk assessment of multiple time-dependent inhibitor systems .
10211917	0	fluoxetine	60,70	CYP2D6	0,6	fluoxetine	CYP2D6	MESH:D005473	1565	Chemical	Gene	status|acl|START_ENTITY status|nummod|END_ENTITY	CYP2D6 status of extensive metabolizers after multiple-dose fluoxetine , fluvoxamine , paroxetine , or sertraline .
10631623	0	fluoxetine	21,31	CYP2D6	0,6	fluoxetine	CYP2D6	MESH:D005473	1565	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nummod|END_ENTITY	CYP2D6 inhibition by fluoxetine , paroxetine , sertraline , and venlafaxine in a crossover study : intraindividual variability and plasma concentration correlations .
11304901	0	fluoxetine	29,39	CYP2D6	77,83	fluoxetine	CYP2D6	MESH:D005473	1565	Chemical	Gene	START_ENTITY|nmod|metabolism metabolism|nmod|dextromethorphan dextromethorphan|appos|probe probe|compound|END_ENTITY	Effect of venlafaxine versus fluoxetine on metabolism of dextromethorphan , a CYP2D6 probe .
12410055	6	fluoxetine	915,925	CYP2D6	884,890	fluoxetine	CYP3A4	MESH:D005473	1576	Chemical	Gene	amiodarone|appos|START_ENTITY inhibitors|dep|amiodarone inhibitors|nummod|END_ENTITY	Possible interactions with CYP2D6 inhibitors -LRB- amiodarone , fluoxetine or ritonavir -RRB- and CYP3A4 inhibitors -LRB- indinavir and ritonavir -RRB- can increase its serum concentrations and produce significant adverse effects .
12584155	0	fluoxetine	92,102	CYP2D6	45,51	fluoxetine	CYP2D6	MESH:D005473	1565	Chemical	Gene	comparison|nmod|START_ENTITY inhibition|dep|comparison inhibition|nmod|END_ENTITY	Apparent mechanism-based inhibition of human CYP2D6 in vitro by paroxetine : comparison with fluoxetine and quinidine .
14716707	0	fluoxetine	105,115	CYP2D6	67,73	fluoxetine	CYP2D6	MESH:D005473	1565	Chemical	Gene	treated|nmod|START_ENTITY evidence|acl|treated evidence|nmod|metabolizers metabolizers|compound|END_ENTITY	No evidence of increased adverse_drug_reactions in cytochrome P450 CYP2D6 poor metabolizers treated with fluoxetine or nortriptyline .
14726986	0	fluoxetine	41,51	CYP2D6	10,16	fluoxetine	CYP2D6	MESH:D005473	1565	Chemical	Gene	concentrations|amod|START_ENTITY genotypes|nmod|concentrations genotypes|nsubj|Effect Effect|nmod|END_ENTITY	Effect of CYP2D6 and CYP2C9 genotypes on fluoxetine and norfluoxetine plasma concentrations during steady-state conditions .
24464553	0	fluoxetine	135,145	CYP2D6	68,74	fluoxetine	CYP2D6	MESH:D005473	1565	Chemical	Gene	N-demethylation|nmod|START_ENTITY polymorphisms|nmod|N-demethylation polymorphisms|nummod|END_ENTITY	Characterizing the effect of cytochrome_P450 _ -LRB- CYP -RRB- _ 2C8 , CYP2C9 , and CYP2D6 genetic polymorphisms on stereoselective N-demethylation of fluoxetine .
24663076	0	fluoxetine	48,58	CYP2D6	10,16	fluoxetine	CYP2D6	MESH:D005473	1565	Chemical	Gene	concentrations|amod|START_ENTITY genotypes|nmod|concentrations genotypes|nsubj|Effect Effect|nmod|END_ENTITY	Effect of CYP2D6 , CYP2C9 and ABCB1 genotypes on fluoxetine plasma concentrations and clinical improvement in children and adolescent patients .
8531073	0	fluoxetine	10,20	CYP3A	82,87	fluoxetine	CYP3A	MESH:D005473	1576	Chemical	Gene	Effect|acl|START_ENTITY Effect|nmod|END_ENTITY	Effect of fluoxetine , norfluoxetine , sertraline and desmethyl_sertraline on human CYP3A catalyzed 1 ' - hydroxy_midazolam formation in vitro .
12404686	0	fluoxetine	52,62	Cytochrome_P450_2D6	0,19	fluoxetine	Cytochrome P450 2D6	MESH:D005473	1565	Chemical	Gene	SSRI|dep|START_ENTITY predict|dobj|SSRI predict|nsubj|genotype genotype|amod|END_ENTITY	Cytochrome_P450_2D6 genotype does not predict SSRI -LRB- fluoxetine or paroxetine -RRB- induced hyponatraemia .
11880651	0	fluoxetine	92,102	DARPP-32	42,50	fluoxetine	DARPP-32	MESH:D005473	19049(Tax:10090)	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of striatal and extrastriatal DARPP-32 in biochemical and behavioral effects of fluoxetine -LRB- Prozac -RRB- .
15522120	0	fluoxetine	41,51	Itch	0,4	fluoxetine	Itch	MESH:D005473	83737	Chemical	Gene	treatment|amod|START_ENTITY END_ENTITY|nmod|treatment	Itch and skin_rash from chocolate during fluoxetine and sertraline treatment : case report .
10051109	0	fluoxetine	34,44	Monoamine_oxidase_A	0,19	fluoxetine	Monoamine oxidase A	MESH:D005473	29253(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|END_ENTITY	Monoamine_oxidase_A inhibition by fluoxetine : an in vitro and in vivo study .
9221950	0	fluoxetine	54,64	Nicotinic_acetylcholine_receptor	0,32	fluoxetine	Nicotinic acetylcholine receptor	MESH:D005473	170945(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|amod|END_ENTITY	Nicotinic_acetylcholine_receptor antagonist effect of fluoxetine in rat hippocampal slices .
12960766	0	fluoxetine	23,33	S100B	43,48	fluoxetine	S100B	MESH:D005473	20203(Tax:10090)	Chemical	Gene	content|compound|START_ENTITY content|compound|END_ENTITY	Both aging and chronic fluoxetine increase S100B content in the mouse hippocampus .
21945287	0	fluoxetine	194,204	Vesicular_Glutamate_Transporter-1	28,61	fluoxetine	Vesicular Glutamate Transporter-1	MESH:D005473	72961(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY expression|dep|effects expression|nmod|END_ENTITY	Increased expression of the Vesicular_Glutamate_Transporter-1 -LRB- VGLUT1 -RRB- in the prefrontal cortex correlates with differential vulnerability to chronic stress in various mouse strains : effects of fluoxetine and MK-801 .
19211973	0	fluoxetine	27,37	brain-derived_neurotrophic_factor	61,94	fluoxetine	brain-derived neurotrophic factor	MESH:D005473	24225(Tax:10116)	Chemical	Gene	co-treatment|nmod|START_ENTITY induces|nsubj|co-treatment induces|dobj|expression expression|amod|END_ENTITY	Repeated co-treatment with fluoxetine and amantadine induces brain-derived_neurotrophic_factor gene expression in rats .
19110026	0	fluoxetine	11,21	brain_derived_neurotrophic_factor	47,80	fluoxetine	brain derived neurotrophic factor	MESH:D005473	627	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|compound|END_ENTITY	Effects of fluoxetine and venlafaxine on serum brain_derived_neurotrophic_factor levels in depressed patients .
7589222	0	fluoxetine	8,18	c-fos	83,88	fluoxetine	c-fos	MESH:D005473	314322(Tax:10116)	Chemical	Gene	mediated|nsubj|START_ENTITY mediated|dobj|expression expression|amod|END_ENTITY	Chronic fluoxetine or desmethylimipramine treatment alters 5-HT2 receptor mediated c-fos gene expression .
6317143	0	fluoxetine	43,53	corticotropin-releasing_factor	57,87	fluoxetine	corticotropin-releasing factor	MESH:D005473	1392	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Effect of the serotonin reuptake inhibitor fluoxetine on corticotropin-releasing_factor and vasopressin secretion into hypophysial portal blood .
8465888	0	fluoxetine	15,25	corticotropin-releasing_hormone	77,108	fluoxetine	corticotropin-releasing hormone	MESH:D005473	1392	Chemical	Gene	treatment|amod|START_ENTITY Association|nmod|treatment Association|nmod|END_ENTITY	Association of fluoxetine treatment with reductions in CSF concentrations of corticotropin-releasing_hormone and arginine_vasopressin in patients with major_depression .
11910262	0	fluoxetine	69,79	cytochrome_P450_2D6	28,47	fluoxetine	cytochrome P450 2D6	MESH:D005473	1565	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|course course|nmod|enzyme enzyme|amod|END_ENTITY	Differential time course of cytochrome_P450_2D6 enzyme inhibition by fluoxetine , sertraline , and paroxetine in healthy volunteers .
8477556	0	fluoxetine	14,24	cytochrome_P450_2D6	28,47	fluoxetine	cytochrome P450 2D6	MESH:D005473	1565	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Inhibition by fluoxetine of cytochrome_P450_2D6 activity .
7694914	0	fluoxetine	10,20	growth_hormone	46,60	fluoxetine	growth hormone	MESH:D005473	2688	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	Effect of fluoxetine on dexamethasone-induced growth_hormone release in depression : a double-blind , placebo-controlled study .
8657961	0	fluoxetine	15,25	insulin	29,36	fluoxetine	insulin	MESH:D005473	3630	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	-LSB- The effect of fluoxetine on insulin resistance in non diabetic_obese patients -RSB- .
10437624	0	fluoxetine	115,125	leptin	17,23	fluoxetine	leptin	MESH:D005473	25608(Tax:10116)	Chemical	Gene	treatment|nmod|START_ENTITY plasma|nmod|treatment plasma|dobj|levels levels|compound|END_ENTITY	Decreased plasma leptin levels in lean and obese Zucker rats after treatment with the serotonin reuptake inhibitor fluoxetine .
15724802	0	fluoxetine	44,54	leptin	58,64	fluoxetine	leptin	MESH:D005473	3952	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Treatment effect of sibutramine compared to fluoxetine on leptin levels in polycystic_ovary_disease .
19823809	0	fluoxetine	83,93	leptin	24,30	fluoxetine	leptin	MESH:D005473	16846(Tax:10090)	Chemical	Gene	comparison|nmod|START_ENTITY effects|dep|comparison produces|dobj|effects produces|nsubj|administration administration|nmod|END_ENTITY	Acute administration of leptin produces anxiolytic-like effects : a comparison with fluoxetine .
19823809	14	fluoxetine	1789,1799	leptin	1801,1807	fluoxetine	leptin	MESH:D005473	16846(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY effects|acl|induced contrast|nmod|effects elicits|nmod|contrast elicits|nsubj|END_ENTITY	CONCLUSIONS : In contrast to anxiogenic-like effects induced by acute fluoxetine , leptin elicits anxiolytic-like effects after acute administration .
9389388	0	fluoxetine	48,58	monoamine_oxidase_B	14,33	fluoxetine	monoamine oxidase B	MESH:D005473	25750(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Evaluation of monoamine_oxidase_B inhibition by fluoxetine -LRB- Prozac -RRB- : an in vitro and in vivo study .
2869958	0	fluoxetine	92,102	myosin	66,72	fluoxetine	myosin	MESH:D005473	79784	Chemical	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Antidepressants and protein kinases : inhibition of Ca2 + - regulated myosin phosphorylation by fluoxetine and iprindole .
16848655	0	fluoxetine	113,123	prolactin	6,15	fluoxetine	prolactin	MESH:D005473	5617	Chemical	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	Serum prolactin levels among outpatients with major_depressive_disorder during the acute phase of treatment with fluoxetine .
7957540	0	fluoxetine	120,130	prolactin	24,33	fluoxetine	prolactin	MESH:D005473	5617	Chemical	Gene	treatment|nmod|START_ENTITY release|nmod|treatment release|nsubj|END_ENTITY	Dexfenfluramine-induced prolactin release as an index of central synaptosomal 5-hydroxytryptamine during treatment with fluoxetine .
14604448	0	fluoxetine	147,157	serotonin_transporter	68,89	fluoxetine	serotonin transporter	MESH:D005473	6532	Chemical	Gene	polymorphisms|acl|START_ENTITY polymorphisms|nmod|subunit subunit|compound|END_ENTITY	Age-dependent antidepressant pharmacogenomics : polymorphisms of the serotonin_transporter and G_protein_beta3 subunit as predictors of response to fluoxetine and nortriptyline .
16490163	0	fluoxetine	31,41	serotonin_transporter	93,114	fluoxetine	serotonin transporter	MESH:D005473	6532	Chemical	Gene	effect|nmod|START_ENTITY oocytes|nsubj|effect oocytes|xcomp|expressing expressing|dobj|END_ENTITY	Electrophysiological effect of fluoxetine on Xenopus oocytes heterologously expressing human serotonin_transporter .
17289086	0	fluoxetine	20,30	serotonin_transporter	54,75	fluoxetine	serotonin transporter	MESH:D005473	6532	Chemical	Gene	treatment|compound|START_ENTITY Effect|nmod|treatment Effect|nmod|END_ENTITY	Effect of long-term fluoxetine treatment on the human serotonin_transporter in Caco-2 cells .
18074800	0	fluoxetine	60,70	serotonin_transporter	27,48	fluoxetine	serotonin transporter	MESH:D005473	25553(Tax:10116)	Chemical	Gene	administration|appos|START_ENTITY administration|nmod|inhibitor inhibitor|compound|END_ENTITY	-LSB- Chronic administration of serotonin_transporter inhibitor -LRB- fluoxetine -RRB- decreases monocrotaline-induced pulmonary_hypertension in rats -RSB- .
19682588	0	fluoxetine	39,49	serotonin_transporter	92,113	fluoxetine	serotonin transporter	MESH:D005473	25553(Tax:10116)	Chemical	Gene	Study|nmod|START_ENTITY Study|nmod|END_ENTITY	Study on the neuroprotective effect of fluoxetine against MDMA-induced neurotoxicity on the serotonin_transporter in rat brain using micro-PET .
2146964	0	fluoxetine	15,25	serotonin_transporter	51,72	fluoxetine	serotonin transporter	MESH:D005473	6532	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of fluoxetine with the human placental serotonin_transporter .
22730080	0	fluoxetine	123,133	serotonin_transporter	28,49	fluoxetine	serotonin transporter	MESH:D005473	25553(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY Hypophagia|nmod|treatment Hypophagia|nmod|expression expression|compound|END_ENTITY	Hypophagia and induction of serotonin_transporter gene expression in raphe nuclei of male and female rats after short-term fluoxetine treatment .
8914125	0	fluoxetine	8,18	serotonin_transporter	27,48	fluoxetine	serotonin transporter	MESH:D005473	25553(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|mRNA mRNA|compound|END_ENTITY	Chronic fluoxetine reduces serotonin_transporter mRNA_and_5-HT1B mRNA in a sequential manner in the rat dorsal raphe nucleus .
22285725	0	fluoxetine	10,20	tryptophan_hydroxylase	42,64	fluoxetine	tryptophan hydroxylase	MESH:D005473	24848(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effect of fluoxetine on the expression of tryptophan_hydroxylase and 14-3-3 protein in the dorsal raphe nucleus and hippocampus of rat .
16982082	0	fluoxetine	34,44	tryptophan_hydroxylase-2	48,72	fluoxetine	tryptophan hydroxylase-2	MESH:D005473	317675(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of repeated treatment with fluoxetine on tryptophan_hydroxylase-2 gene expression in the rat brainstem .
17950541	0	fluoxetine	75,85	tryptophan_hydroxylase-2	17,41	fluoxetine	tryptophan hydroxylase-2	MESH:D005473	317675(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY brain|nmod|treatment mRNA|nmod|brain mRNA|amod|END_ENTITY	Up-regulation of tryptophan_hydroxylase-2 mRNA in the rat brain by chronic fluoxetine treatment correlates with its antidepressant effect .
16414576	0	fluoxetine_hydrochloride	66,90	tryptophan_pyrrolase	33,53	fluoxetine hydrochloride	tryptophan pyrrolase	MESH:D005473	64206(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Similar pattern of inhibition of tryptophan_pyrrolase activity by fluoxetine_hydrochloride in both sexes of rats .
23788904	0	fluphenazine	4,16	P-glycoprotein	44,58	fluphenazine	P-glycoprotein	MESH:D005476	5243	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	New fluphenazine analogues as inhibitors of P-glycoprotein in human lymphocyte cultures .
9344576	0	flupirtine	10,20	Bcl-2	24,29	flupirtine	Bcl-2	MESH:C034161	596	Chemical	Gene	START_ENTITY|nmod|level level|amod|END_ENTITY	Effect of flupirtine on Bcl-2 and glutathione level in neuronal cells treated in vitro with the prion_protein fragment -LRB- PrP106-126 -RRB- .
21448308	0	flurbiprofen	11,23	CRP	27,30	flurbiprofen	CRP	MESH:D005480	1401	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of flurbiprofen on CRP , TNF-a , IL-6 , and postoperative_pain of thoracotomy .
8426248	0	flurbiprofen	10,22	bradykinin	58,68	flurbiprofen	bradykinin	MESH:D005480	3827	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of flurbiprofen on tissue levels of immunoreactive bradykinin and acute postoperative_pain .
26662445	0	flurbiprofen_axetil	11,30	IL-2	54,58	flurbiprofen axetil	IL-2	MESH:C504422	3558	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of flurbiprofen_axetil on postoperative serum IL-2 and IL-6 levels in patients with colorectal_cancer .
7270	0	fluroxene	48,57	cytochrome_P-450	12,28	fluroxene	cytochrome P-450	MESH:C084587	4051	Chemical	Gene	toxicity|nmod|START_ENTITY END_ENTITY|nmod|toxicity	The role of cytochrome_P-450 in the toxicity of fluroxene -LRB- 2,2,2-trifluoroethyl vinyl ether -RRB- anaesthesia in vivo .
8496305	0	flutamide	32,41	Androgen_receptor	0,17	flutamide	Androgen receptor	MESH:D005485	367	Chemical	Gene	blockade|nmod|START_ENTITY blockade|amod|END_ENTITY	Androgen_receptor blockade with flutamide enhances growth hormone secretion in late pubertal males : evidence for independent actions of estrogen and androgen .
19853283	0	flutamide	124,133	Connexin_43	0,11	flutamide	Connexin 43	MESH:D005485	100518636	Chemical	Gene	anti-androgen|appos|START_ENTITY exposure|nmod|anti-androgen offspring|advcl|exposure offspring|nsubj|expression expression|amod|END_ENTITY	Connexin_43 gene expression in male and female gonads of porcine offspring following in utero exposure to an anti-androgen , flutamide .
24865629	0	flutamide	96,105	Connexin_43	0,11	flutamide	Connexin 43	MESH:D005485	24392(Tax:10116)	Chemical	Gene	epithelium|xcomp|START_ENTITY epithelium|nsubj|expression expression|amod|END_ENTITY	Connexin_43 expression in Sprague-Dawley_rat seminiferous epithelium after in utero exposure to flutamide .
12970085	0	flutamide	68,77	GLUT1	162,167	flutamide	GLUT1	MESH:D005485	6513	Chemical	Gene	START_ENTITY|nmod|site site|nmod|END_ENTITY	Interactions of androgens , green tea catechins and the antiandrogen flutamide with the external glucose-binding site of the human erythrocyte glucose transporter GLUT1 .
10071551	0	flutamide	25,34	LHRH	81,85	flutamide	LHRH	MESH:D005485	2796	Chemical	Gene	Combination|nmod|START_ENTITY Combination|nsubj|D-Trp6 D-Trp6|appos|ethylamide ethylamide|compound|END_ENTITY	Combination therapy with flutamide and the LHRH agonist -LSB- D-Trp6 , des-Gly-NH -LRB- 2 -RRB- 10 -RSB- LHRH ethylamide in stage C prostatic_carcinoma .
1546420	0	flutamide	121,130	LHRH	84,88	flutamide	LHRH	MESH:D005485	2796	Chemical	Gene	treated|nmod|START_ENTITY treated|nmod|agonist agonist|compound|END_ENTITY	Transrectal ultrasound evaluation of local_prostate_cancer in patients treated with LHRH agonist and in combination with flutamide .
2144819	0	flutamide	61,70	LHRH	99,103	flutamide	LHRH	MESH:D005485	2796	Chemical	Gene	START_ENTITY|nmod|patients patients|acl|pretreated pretreated|nmod|analogue analogue|amod|END_ENTITY	Advanced prostatic_cancer : clinical and hormonal response to flutamide in patients pretreated with LHRH analogue and cyproterone_acetate .
2285608	0	flutamide	25,34	LHRH	48,52	flutamide	LHRH	MESH:D005485	2796	Chemical	Gene	agonist|compound|START_ENTITY agonist|compound|END_ENTITY	Combination therapy with flutamide and medical -LRB- LHRH agonist -RRB- or surgical castration in advanced_prostate_cancer : 7-year clinical experience .
2934579	0	flutamide	25,34	LHRH	51,55	flutamide	LHRH	MESH:D005485	2796	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Combination therapy with flutamide and castration -LRB- LHRH agonist or orchiectomy -RRB- in advanced_prostate_cancer : a marked improvement in response and survival .
3290578	0	flutamide	25,34	LHRH	51,55	flutamide	LHRH	MESH:D005485	2796	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Combination therapy with flutamide and castration -LRB- LHRH agonist or orchiectomy -RRB- in previously untreated patients with clinical stage D2 prostate_cancer : today 's therapy of choice .
10705202	0	flutamide	58,67	Prostate-specific_antigen	0,25	flutamide	Prostate-specific antigen	MESH:D005485	354	Chemical	Gene	levels|acl|START_ENTITY levels|amod|END_ENTITY	Prostate-specific_antigen levels and clinical response to flutamide as the second hormone therapy for hormone-refractory prostate_carcinoma .
16275987	0	flutamide	42,51	androgen_receptor	8,25	flutamide	androgen receptor	MESH:D005485	367	Chemical	Gene	treatment|amod|START_ENTITY function|nmod|treatment function|nsubj|END_ENTITY	Imaging androgen_receptor function during flutamide treatment in the LAPC9 xenograft model .
16631174	0	flutamide	68,77	androgen_receptor	38,55	flutamide	androgen receptor	MESH:D005485	24208(Tax:10116)	Chemical	Gene	increase|advmod|START_ENTITY increase|nsubj|administration administration|nmod|antagonist antagonist|compound|END_ENTITY	Intrahippocampal administration of an androgen_receptor antagonist , flutamide , can increase anxiety-like behavior in intact and DHT-replaced male rats .
21126777	0	flutamide	63,72	androgen_receptor	33,50	flutamide	androgen receptor	MESH:D005485	100005148(Tax:7955)	Chemical	Gene	START_ENTITY|nsubj|profiling profiling|nmod|antagonists antagonists|compound|END_ENTITY	Gene expression profiling of the androgen_receptor antagonists flutamide and vinclozolin in zebrafish -LRB- Danio_rerio -RRB- gonads .
21605098	0	flutamide	76,85	androgen_receptor	47,64	flutamide	androgen receptor	MESH:D005485	367	Chemical	Gene	START_ENTITY|nsubj|Treatment Treatment|nmod|loss loss|nmod|antagonist antagonist|compound|END_ENTITY	Treatment of female pattern hair loss with the androgen_receptor antagonist flutamide .
3964747	0	flutamide	39,48	androgen_receptor	53,70	flutamide	androgen receptor	MESH:D005485	11835(Tax:10090)	Chemical	Gene	antiandrogen|appos|START_ENTITY Effect|nmod|antiandrogen Effect|nmod|dynamics dynamics|compound|END_ENTITY	Effect of a nonsteroidal antiandrogen , flutamide , on androgen_receptor dynamics and ornithine_decarboxylase gene expression in mouse kidney .
24139236	0	flutamide	10,19	c-Kit	93,98	flutamide	c-Kit	MESH:D005485	396810(Tax:9823)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|END_ENTITY	Effect of flutamide on folliculogenesis in the fetal porcine ovary -- regulation by Kit_ligand / c-Kit and IGF1/IGF1R systems .
20558338	0	flutamide	42,51	connexin_43	55,66	flutamide	connexin 43	MESH:D005485	100518636	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effects of pre - and postnatal exposure to flutamide on connexin_43 expression in testes and ovaries of prepubertal pigs .
20961722	0	flutamide	51,60	connexin_43	68,79	flutamide	connexin 43	MESH:D005485	100518636	Chemical	Gene	exposure|nmod|START_ENTITY alters|nsubj|exposure alters|dobj|expression expression|amod|END_ENTITY	Prenatal and neonatal exposure to the antiandrogen flutamide alters connexin_43 gene expression in adult porcine ovary .
23571006	0	flutamide	39,48	connexin_43	60,71	flutamide	connexin 43	MESH:D005485	100518636	Chemical	Gene	exposure|nmod|START_ENTITY influences|nsubj|exposure influences|dobj|expression expression|amod|END_ENTITY	In utero exposure to the anti-androgen flutamide influences connexin_43 and b-catenin expression in porcine fetal gonads .
9797851	0	flutamide	11,20	corticotrophin_releasing_factor	64,95	flutamide	corticotrophin releasing factor	MESH:D005485	1392	Chemical	Gene	Effects|nmod|START_ENTITY responsiveness|nsubj|Effects responsiveness|nmod|END_ENTITY	Effects of flutamide on pituitary and adrenal responsiveness to corticotrophin_releasing_factor -LRB- CRF -RRB- .
12567773	0	flutamide	19,28	cytochrome_P450_1A2	64,83	flutamide	cytochrome P450 1A2	MESH:D005485	24297(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY Sex-difference|nmod|metabolism microsomal|nsubj|Sex-difference microsomal|dobj|-RSB- -RSB-|amod|END_ENTITY	-LSB- Sex-difference on flutamide metabolism in rat liver microsomal cytochrome_P450_1A2 -RSB- .
16225762	0	flutamide	53,62	cytochrome_P450_1A2	19,38	flutamide	cytochrome P450 1A2	MESH:D005485	24297(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Induction of liver cytochrome_P450_1A2 expression by flutamide in rats .
14706014	0	flutamide	178,187	luteinizing_hormone-releasing_hormone	193,230	flutamide	luteinizing hormone-releasing hormone	MESH:D005485	2796	Chemical	Gene	START_ENTITY|nmod|agonist agonist|amod|END_ENTITY	Chemohormonal therapy as primary treatment for metastatic_prostate_cancer : a randomized study of estramustine_phosphate plus luteinizing_hormone-releasing_hormone agonist versus flutamide plus luteinizing_hormone-releasing_hormone agonist .
9634122	0	flutamide	48,57	prostate-specific_antigen	10,35	flutamide	prostate-specific antigen	MESH:D005485	354	Chemical	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Prolonged prostate-specific_antigen response in flutamide withdrawal_syndrome despite disease progression .
21690510	0	fluticasone_furoate	10,29	interleukin_6	33,46	fluticasone furoate	interleukin 6	MESH:C523187	3569	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|amod|END_ENTITY	Effect of fluticasone_furoate on interleukin_6 secretion from adenoid tissues in children with obstructive_sleep_apnea .
18699801	0	fluticasone_propionate	19,41	CD4	61,64	fluticasone propionate	CD4	MESH:C065382	920	Chemical	Gene	START_ENTITY|nmod|CD25 CD25|compound|END_ENTITY	Effects of inhaled fluticasone_propionate on CTLA-4-positive CD4 + CD25 + cells in induced sputum in mild asthmatics .
9543078	0	fluticasone_propionate	11,33	ICAM-1	42,48	fluticasone propionate	ICAM-1	MESH:C065382	3383	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	Intranasal fluticasone_propionate reduces ICAM-1 on nasal epithelial cells both during early and late phase after allergen challenge .
12137248	0	fluticasone_propionate	20,42	IL-13	46,51	fluticasone propionate	IL-13	MESH:C065382	3596	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	In vitro effects of fluticasone_propionate on IL-13 production by mitogen-stimulated lymphocytes .
10200007	0	fluticasone_propionate	62,84	glucocorticoid_receptor	22,45	fluticasone propionate	glucocorticoid receptor	MESH:C065382	2908	Chemical	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	In vivo modulation of glucocorticoid_receptor mRNA by inhaled fluticasone_propionate in bronchial mucosa and blood lymphocytes in subjects with mild asthma .
12207111	0	fluticasone_propionate	19,41	interleukin_8	45,58	fluticasone propionate	interleukin 8	MESH:C065382	3576	Chemical	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	In vitro effect of fluticasone_propionate on interleukin_8 production by monocytes obtained from patients affected by moderate-severe allergic_asthma .
6141186	0	flutroline_hydrochloride	26,50	prolactin	4,13	flutroline hydrochloride	prolactin	null	5617	Chemical	Gene	START_ENTITY|nsubj|response response|compound|END_ENTITY	The prolactin response to flutroline_hydrochloride in schizophrenic patients .
15623649	0	fluvastatin	59,70	3-hydroxy-3-methylglutaryl-coenzyme_a_reductase	0,47	fluvastatin	3-hydroxy-3-methylglutaryl-coenzyme a reductase	MESH:C065180	15357(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	3-hydroxy-3-methylglutaryl-coenzyme_a_reductase inhibitor , fluvastatin , as a novel agent for prophylaxis of renal_cancer metastasis .
8937733	0	fluvastatin	22,33	ACE	98,101	fluvastatin	ACE	MESH:C065180	100009274(Tax:9986)	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nsubj|effects	Inhibitory effects of fluvastatin , a new HMG-CoA reductase inhibitor , on the increase in vascular ACE activity in cholesterol-fed rabbits .
12480587	0	fluvastatin	12,23	C-reactive_protein	41,59	fluvastatin	C-reactive protein	MESH:C065180	1401	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|nmod|END_ENTITY	-LSB- Effects of fluvastatin on the levels of C-reactive_protein and lipids in patients with hyperlipidemia -RSB- .
10197301	0	fluvastatin	15,26	CYP2C9	30,36	fluvastatin	CYP2C9	MESH:C065180	1559	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	The effects of fluvastatin , a CYP2C9 inhibitor , on losartan pharmacokinetics in healthy volunteers .
16758259	0	fluvastatin	11,22	CYP2C9	48,54	fluvastatin	CYP2C9	MESH:C065180	1559	Chemical	Gene	smoking|compound|START_ENTITY smoking|nmod|activity activity|compound|END_ENTITY	Effects of fluvastatin and cigarette smoking on CYP2C9 activity measured using the probe S-warfarin .
22941809	0	fluvastatin	98,109	CYP2C9	0,6	fluvastatin	CYP2C9	MESH:C065180	1559	Chemical	Gene	pharmacokinetics|compound|START_ENTITY variability|nmod|pharmacokinetics determinants|nmod|variability determinants|nsubj|G2677T/A G2677T/A|compound|END_ENTITY	CYP2C9 * 3 -LRB- 1075A > C -RRB- , MDR1 G2677T/A and MDR1 C3435T are determinants of inter-subject variability in fluvastatin pharmacokinetics in healthy Chinese volunteers .
24024895	0	fluvastatin	121,132	CYP2C9	0,6	fluvastatin	CYP2C9	MESH:C065180	1559	Chemical	Gene	taking|dobj|START_ENTITY patients|acl|taking developing|nmod|patients factors|acl|developing polymorphisms|nmod|factors polymorphisms|nsubj|END_ENTITY	CYP2C9 and ABCG2 polymorphisms as risk factors for developing adverse drug reactions in renal transplant patients taking fluvastatin : a case-control study .
25280537	0	fluvastatin	53,64	CYP2C9	115,121	fluvastatin	CYP2C9	MESH:C065180	1559	Chemical	Gene	combination|nmod|START_ENTITY caused|nmod|combination caused|nmod|heterozygous heterozygous|nmod|END_ENTITY	Creatine kinase elevation caused by a combination of fluvastatin and telmisartan in a patient heterozygous for the CYP2C9 * 3 and ABCC2 -24 C _ > _ T variants : a case report .
1854361	0	fluvastatin	11,22	HMG-CoA_reductase	39,56	fluvastatin	HMG-CoA reductase	MESH:C065180	3156	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|inhibitor inhibitor|amod|END_ENTITY	Effects of fluvastatin -LRB- XU_62-320 -RRB- , an HMG-CoA_reductase inhibitor , on the distribution and composition of low density lipoprotein subspecies in humans .
21826199	0	fluvastatin	28,39	IL-8	43,47	fluvastatin	IL-8	MESH:C065180	3576	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Anti-inflammatory effect of fluvastatin on IL-8 production induced by Pseudomonas_aeruginosa and Aspergillus_fumigatus antigens in cystic_fibrosis .
18611343	0	fluvastatin	12,23	Janus_kinase_2	45,59	fluvastatin	Janus kinase 2	MESH:C065180	24514(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of fluvastatin on the expression of Janus_kinase_2 / signal transducers and activators of transcription -LRB- JAK/STAT -RRB- in glomerular mesangial cells under high concentration of glucose -RSB- .
24657892	0	fluvastatin	74,85	Pin1	41,45	fluvastatin	Pin1	MESH:C065180	298696(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY Involvement|nmod|effect Involvement|nmod|END_ENTITY	Involvement of peptidyl-prolyl isomerase Pin1 in the inhibitory effect of fluvastatin on endothelin-1-induced cardiomyocyte hypertrophy .
16649978	0	fluvastatin	14,25	adiponectin	36,47	fluvastatin	adiponectin	MESH:C065180	9370	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|levels levels|compound|END_ENTITY	The effect of fluvastatin on plasma adiponectin levels in dyslipidaemia .
12374897	0	fluvastatin	25,36	angiotensin_II	70,84	fluvastatin	angiotensin II	MESH:C065180	183	Chemical	Gene	effects|nmod|START_ENTITY activated|nsubj|effects activated|nmod|END_ENTITY	Antioxidative effects of fluvastatin on superoxide anion activated by angiotensin_II in human aortic smooth muscle cells .
11071065	0	fluvastatin	95,106	apolipoprotein_B	19,35	fluvastatin	apolipoprotein B	MESH:C065180	338	Chemical	Gene	polymorphisms|xcomp|START_ENTITY polymorphisms|nsubj|Association Association|nmod|gene gene|amod|END_ENTITY	Association of the apolipoprotein_B gene polymorphisms with cholesterol levels and response to fluvastatin in Brazilian individuals with high risk for coronary_heart_disease .
11217077	0	fluvastatin	21,32	apolipoprotein_B	51,67	fluvastatin	apolipoprotein B	MESH:C065180	338	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Protective effect of fluvastatin on degradation of apolipoprotein_B by a radical reaction in human plasma .
10780315	0	fluvastatin	11,22	fibrinogen	61,71	fluvastatin	fibrinogen	MESH:C065180	2244	Chemical	Gene	combination|compound|START_ENTITY Effects|nmod|combination Effects|nmod|END_ENTITY	Effects of fluvastatin and bezafibrate combination on plasma fibrinogen , t-plasminogen_activator inhibitor and C_reactive_protein levels in coronary_artery_disease patients with mixed_hyperlipidaemia -LRB- FACT study -RRB- .
12094825	0	fluvastatin	14,25	fibrinogen	36,46	fluvastatin	fibrinogen	MESH:C065180	2244	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|levels levels|compound|END_ENTITY	The effect of fluvastatin on plasma fibrinogen levels .
17919370	0	fluvastatin	10,21	vascular_endothelial_growth_factor	25,59	fluvastatin	vascular endothelial growth factor	MESH:C065180	83785(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of fluvastatin on vascular_endothelial_growth_factor in rats with osteoporosis in process of fracture healing .
8192170	0	fluvastatin-bezafibrate	37,60	familial_hypercholesterolemia	75,104	fluvastatin-bezafibrate	familial hypercholesterolemia	null	3949	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|END_ENTITY	Efficacy and safety of a combination fluvastatin-bezafibrate treatment for familial_hypercholesterolemia : comparative analysis with a fluvastatin-cholestyramine combination .
8466953	0	fluvastatin_sodium	10,28	low-density_lipoprotein_receptor	129,161	fluvastatin sodium	low-density lipoprotein receptor	MESH:C065180	3949	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|induction induction|nmod|END_ENTITY	Effect of fluvastatin_sodium -LRB- XU62-320 -RRB- , a new inhibitor of 3-hydroxy-3-methylglutaryl_coenzyme_A reductase , on the induction of low-density_lipoprotein_receptor in HepG2 cells .
7797440	0	fluvirucin_B2	72,85	phosphatidylinositol-specific_phospholipase_C	14,59	fluvirucin B2	phosphatidylinositol-specific phospholipase C	MESH:C094360	23236	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activity activity|amod|END_ENTITY	Inhibition of phosphatidylinositol-specific_phospholipase_C activity by fluvirucin_B2 .
10627170	0	fluvoxamine	60,71	CYP1A2	90,96	fluvoxamine	CYP1A2	MESH:D016666	1544	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|compound|END_ENTITY	CYP2C9 is a principal low-affinity phenacetin O-deethylase : fluvoxamine is not a specific CYP1A2 inhibitor .
9209244	0	fluvoxamine	34,45	CYP1A2	17,23	fluvoxamine	CYP1A2	MESH:D016666	1544	Chemical	Gene	START_ENTITY|nsubj|Influence Influence|nmod|inhibitor inhibitor|compound|END_ENTITY	Influence of the CYP1A2 inhibitor fluvoxamine on tacrine pharmacokinetics in humans .
9757149	0	fluvoxamine	10,21	CYP1A2	51,57	fluvoxamine	CYP1A2	MESH:D016666	1544	Chemical	Gene	therapy|amod|START_ENTITY Effect|nmod|therapy Effect|nmod|END_ENTITY	Effect of fluvoxamine therapy on the activities of CYP1A2 , CYP2D6 , and CYP3A as determined by phenotyping .
12222750	0	fluvoxamine	20,31	CYP2C19	47,54	fluvoxamine	CYP2C19	MESH:D016666	1557	Chemical	Gene	START_ENTITY|nmod|relation relation|nmod|END_ENTITY	Pharmacokinetics of fluvoxamine in relation to CYP2C19 phenotype and genotype .
12695344	0	fluvoxamine	59,70	CYP2C19	78,85	fluvoxamine	CYP2C19	MESH:D016666	1557	Chemical	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|END_ENTITY	Comparison of in vitro and in vivo inhibition potencies of fluvoxamine toward CYP2C19 .
12698310	0	fluvoxamine	23,34	CYP2C19	118,125	fluvoxamine	CYP2C19	MESH:D016666	1557	Chemical	Gene	Effects|nmod|START_ENTITY Effects|dep|interaction interaction|nmod|alleles alleles|nummod|mutated mutated|compound|END_ENTITY	Effects of concomitant fluvoxamine on the metabolism of alprazolam in Japanese psychiatric patients : interaction with CYP2C19 mutated alleles .
15025747	0	fluvoxamine	31,42	CYP2C19	76,83	fluvoxamine	CYP2C19	MESH:D016666	1557	Chemical	Gene	START_ENTITY|nmod|metabolism metabolism|nmod|END_ENTITY	Different inhibitory effect of fluvoxamine on omeprazole metabolism between CYP2C19 genotypes .
15496639	0	fluvoxamine	11,22	CYP2C19	71,78	fluvoxamine	CYP2C19	MESH:D016666	1557	Chemical	Gene	Effects|nmod|START_ENTITY pharmacokinetics|nsubj|Effects pharmacokinetics|nmod|genotypes genotypes|nummod|END_ENTITY	Effects of fluvoxamine on lansoprazole pharmacokinetics in relation to CYP2C19 genotypes .
15963095	0	fluvoxamine	97,108	CYP2C19	60,67	fluvoxamine	CYP2C19	MESH:D016666	1557	Chemical	Gene	presence|nmod|START_ENTITY genotypes|nmod|presence genotypes|nsubj|disposition disposition|nmod|lansoprazole lansoprazole|nmod|relation relation|nmod|END_ENTITY	Enantioselective disposition of lansoprazole in relation to CYP2C19 genotypes in the presence of fluvoxamine .
16487224	0	fluvoxamine	21,32	CYP2C19	80,87	fluvoxamine	CYP2C19	MESH:D016666	1557	Chemical	Gene	effects|nmod|START_ENTITY pharmacokinetics|nsubj|effects pharmacokinetics|nmod|status status|compound|END_ENTITY	Different effects of fluvoxamine on rabeprazole pharmacokinetics in relation to CYP2C19 genotype status .
8904628	0	fluvoxamine	48,59	CYP2C19	22,29	fluvoxamine	CYP2C19	MESH:D016666	1557	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	In vivo inhibition of CYP2C19 but not CYP2D6 by fluvoxamine .
21044620	0	fluvoxamine	34,45	Sigma-1_receptor	0,16	fluvoxamine	Sigma-1 receptor	MESH:D016666	29336(Tax:10116)	Chemical	Gene	stimulation|nmod|START_ENTITY stimulation|amod|END_ENTITY	Sigma-1_receptor stimulation with fluvoxamine activates Akt-eNOS signaling in the thoracic aorta of ovariectomized rats with abdominal aortic banding .
9716316	0	fluvoxamine	40,51	c-fos	12,17	fluvoxamine	c-fos	MESH:D016666	314322(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY expression|acl|induced expression|amod|END_ENTITY	Patterns of c-fos expression induced by fluvoxamine are different after acute vs. chronic oral administration .
11673783	0	fluvoxamine	58,69	corticotropin-releasing_hormone	116,147	fluvoxamine	corticotropin-releasing hormone	MESH:D016666	81648(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY mediated|nsubjpass|effects mediated|nmod|END_ENTITY	The effects of the selective serotonin reuptake-inhibitor fluvoxamine on body weight in Zucker rats are mediated by corticotropin-releasing_hormone .
11907488	0	fluvoxamine	35,46	cytochrome_P4501A2	88,106	fluvoxamine	cytochrome P4501A2	MESH:D016666	1544	Chemical	Gene	doses|nmod|START_ENTITY inhibit|nsubj|doses inhibit|dobj|metabolism metabolism|nmod|caffeine caffeine|appos|END_ENTITY	Low daily 10-mg and 20-mg doses of fluvoxamine inhibit the metabolism of both caffeine -LRB- cytochrome_P4501A2 -RRB- and omeprazole -LRB- cytochrome P4502C19 -RRB- .
11817517	0	fluvoxamine	104,115	serotonin_transporter	17,38	fluvoxamine	serotonin transporter	MESH:D016666	6532	Chemical	Gene	gene-linked|advcl|START_ENTITY gene-linked|nsubj|Influence Influence|nmod|END_ENTITY	Influence of the serotonin_transporter gene-linked polymorphic region on the antidepressant response to fluvoxamine in Japanese depressed patients .
12374640	0	fluvoxamine	117,128	serotonin_transporter	43,64	fluvoxamine	serotonin transporter	MESH:D016666	6532	Chemical	Gene	affect|advcl|START_ENTITY affect|nsubj|number number|nmod|repeats repeats|nmod|gene gene|compound|END_ENTITY	A variable number of tandem repeats in the serotonin_transporter gene does not affect the antidepressant response to fluvoxamine .
12695316	0	fluvoxamine	110,121	serotonin_transporter	15,36	fluvoxamine	serotonin transporter	MESH:D016666	6532	Chemical	Gene	study|nmod|START_ENTITY study|nsubj|levels levels|nmod|occupancy occupancy|compound|END_ENTITY	High levels of serotonin_transporter occupancy with low-dose clomipramine in comparative occupancy study with fluvoxamine using positron emission tomography .
16119478	0	fluvoxamine	21,32	serotonin_transporter	66,87	fluvoxamine	serotonin transporter	MESH:D016666	6532	Chemical	Gene	polymorphism|amod|START_ENTITY efficacy|nmod|polymorphism efficacy|nmod|gene gene|compound|END_ENTITY	Clinical efficacy of fluvoxamine and functional polymorphism in a serotonin_transporter gene on childhood autism .
9857976	0	fluvoxamine	98,109	serotonin_transporter	40,61	fluvoxamine	serotonin transporter	MESH:D016666	6532	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Polymorphism within the promoter of the serotonin_transporter gene and antidepressant efficacy of fluvoxamine .
20722474	0	fluvoxamine	32,43	sigma-1_receptor	10,26	fluvoxamine	sigma-1 receptor	MESH:D016666	29336(Tax:10116)	Chemical	Gene	Targeting|nmod|START_ENTITY Targeting|xcomp|END_ENTITY	Targeting sigma-1_receptor with fluvoxamine ameliorates pressure-overload-induced hypertrophy and dysfunctions .
22293694	0	fluvoxamine	28,39	sigma-1_receptor	41,57	fluvoxamine	sigma-1 receptor	MESH:D016666	18391(Tax:10090)	Chemical	Gene	agonist|amod|START_ENTITY agonist|amod|END_ENTITY	-LSB- Cardioprotective effect of fluvoxamine , sigma-1_receptor high affinity agonist -RSB- .
23041149	0	fluvoxamine	73,84	sigma1_receptor	19,34	fluvoxamine	sigma1 receptor	MESH:D016666	18391(Tax:10090)	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of the sigma1_receptor in the antidepressant-like effects of fluvoxamine in the forced swimming test in comparison with the effects elicited by paroxetine .
7961804	0	fodrin	12,18	CD45	37,41	fodrin	CD45	null	5788	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Mapping the fodrin binding domain in CD45 , a leukocyte membrane-associated tyrosine phosphatase .
10590231	0	folate	22,28	Apc	32,35	folate	Apc	MESH:D005492	24205(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|mutations mutations|compound|END_ENTITY	The effect of dietary folate on Apc and p53 mutations in the dimethylhydrazine rat model of colorectal_cancer .
15047700	1	folate	128,134	BCRP	111,115	folate	BCRP	MESH:D005492	9429	Chemical	Gene	homeostasis|compound|START_ENTITY role|nmod|homeostasis role|nmod|END_ENTITY	A role for BCRP in cellular folate homeostasis .
10339503	0	folate	70,76	CD34	89,93	folate	CD34	MESH:D005492	947	Chemical	Gene	receptor|amod|START_ENTITY receptor|nmod|END_ENTITY	Expression and functional characterization of the beta-isoform of the folate receptor on CD34 -LRB- + -RRB- cells .
23332600	0	folate	95,101	DNA_methyltransferase	0,21	folate	DNA methyltransferase	MESH:D005492	1786	Chemical	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	DNA_methyltransferase mediates dose-dependent stimulation of neural stem cell proliferation by folate .
26354538	0	folate	80,86	Dihydrofolate_reductase	0,23	folate	Dihydrofolate reductase	MESH:D005492	1719	Chemical	Gene	status|amod|START_ENTITY association|nmod|status modifies|dobj|association modifies|nsubj|polymorphism polymorphism|amod|END_ENTITY	Dihydrofolate_reductase 19-bp deletion polymorphism modifies the association of folate status with memory in a cross-sectional multi-ethnic study of adults .
21210071	2	folate	398,404	GNMT	369,373	folate	GNMT	MESH:D005492	27232	Chemical	Gene	protein|compound|START_ENTITY protein|nsubj|END_ENTITY	GNMT is also a major hepatic folate binding protein that binds to , and , subsequently , may be inhibited by 5-methyltetrafolate .
6587377	0	folate	33,39	Glycine_N-methyltransferase	0,27	folate	Glycine N-methyltransferase	MESH:D005492	25134(Tax:10116)	Chemical	Gene	protein|amod|START_ENTITY protein|nsubj|END_ENTITY	Glycine_N-methyltransferase is a folate binding protein of rat liver cytosol .
24639464	0	folate	14,20	LRP2	0,4	folate	LRP2	MESH:D005492	14725(Tax:10090)	Chemical	Gene	uptake|amod|START_ENTITY mediates|dobj|uptake mediates|nsubj|END_ENTITY	LRP2 mediates folate uptake in the developing neural tube .
12560354	0	folate	67,73	MTHFR	93,98	folate	MTHFR	MESH:D005492	4524	Chemical	Gene	START_ENTITY|nmod|relation relation|nmod|END_ENTITY	Effect of riboflavin status on the homocysteine-lowering effect of folate in relation to the MTHFR -LRB- C677T -RRB- genotype .
12949355	0	folate	18,24	MTHFR	148,153	folate	MTHFR	MESH:D005492	4524	Chemical	Gene	affect|nsubj|START_ENTITY affect|nmod|homozygous homozygous|nmod|mutation mutation|compound|END_ENTITY	Combined marginal folate and riboflavin status affect homocysteine methylation in cultured immortalized lymphocytes from persons homozygous for the MTHFR C677T mutation .
15040829	0	folate	132,138	MTHFR	81,86	folate	MTHFR	MESH:D005492	4524	Chemical	Gene	status|compound|START_ENTITY depends|nmod|status depends|nsubj|Association Association|nmod|polymorphism polymorphism|nmod|gene gene|appos|END_ENTITY	Association of a common polymorphism in the methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene with bone phenotypes depends on plasma folate status .
15777680	0	folate	72,78	MTHFR	15,20	folate	MTHFR	MESH:D005492	4524	Chemical	Gene	women|nmod|START_ENTITY genotype|nmod|women genotype|nsubj|effects effects|nmod|END_ENTITY	Are effects of MTHFR -LRB- C677T -RRB- genotype on BMD confined to women with low folate and riboflavin intake ?
16216822	0	folate	163,169	MTHFR	17,22	folate	MTHFR	MESH:D005492	4524	Chemical	Gene	potential|nmod|START_ENTITY role|nmod|potential does|nsubj|role Meta-analysis|parataxis|does Meta-analysis|nmod|END_ENTITY	Meta-analysis of MTHFR 677C - > T polymorphism and coronary_heart_disease : does totality of evidence support causal role for homocysteine and preventive potential of folate ?
16524711	0	folate	16,22	MTHFR	111,116	folate	MTHFR	MESH:D005492	4524	Chemical	Gene	improves|nsubj|START_ENTITY improves|nmod|women women|nmod|CC CC|compound|END_ENTITY	Additional food folate derived exclusively from natural sources improves folate status in young women with the MTHFR 677 CC or TT genotype .
16524711	0	folate	73,79	MTHFR	111,116	folate	MTHFR	MESH:D005492	4524	Chemical	Gene	status|amod|START_ENTITY improves|dobj|status improves|nmod|women women|nmod|CC CC|compound|END_ENTITY	Additional food folate derived exclusively from natural sources improves folate status in young women with the MTHFR 677 CC or TT genotype .
16524890	0	folate	109,115	MTHFR	9,14	folate	MTHFR	MESH:D005492	4524	Chemical	Gene	supplementation|compound|START_ENTITY modification|nmod|supplementation factor|dep|modification factor|nsubj|T T|compound|END_ENTITY	Maternal MTHFR 677C > T is a risk factor for congenital heart_defects : effect modification by periconceptional folate supplementation .
17071478	1	folate	206,212	MTHFR	155,160	folate	MTHFR	MESH:D005492	4524	Chemical	Gene	metabolism|nmod|START_ENTITY enzyme|nmod|metabolism enzyme|nsubj|Methylenetetrahydrofolate_reductase Methylenetetrahydrofolate_reductase|appos|END_ENTITY	Methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- is an essential enzyme in the metabolism of folate .
17219389	0	folate	50,56	MTHFR	19,24	folate	MTHFR	MESH:D005492	4524	Chemical	Gene	intake|compound|START_ENTITY genotype|appos|intake genotype|compound|END_ENTITY	Fetal and maternal MTHFR C677T genotype , maternal folate intake and the risk of nonsyndromic_oral_clefts .
17301267	0	folate	8,14	MTHFR	42,47	folate	MTHFR	MESH:D005492	4524	Chemical	Gene	intake|amod|START_ENTITY intake|nmod|combination combination|nmod|genotype genotype|amod|END_ENTITY	Dietary folate intake in combination with MTHFR C677T genotype and promoter methylation of tumor suppressor and DNA repair genes in sporadic colorectal_adenomas .
18053312	0	folate	192,198	MTHFR	58,63	folate	MTHFR	MESH:D005492	4524	Chemical	Gene	intake|compound|START_ENTITY population|nmod|intake study|nmod|population Polymorphisms|dep|study Polymorphisms|nmod|gene gene|appos|END_ENTITY	Polymorphisms in the methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene , intakes of folate and related B_vitamins and colorectal_cancer : a case-control study in a population with relatively low folate intake .
18053312	0	folate	82,88	MTHFR	58,63	folate	MTHFR	MESH:D005492	4524	Chemical	Gene	B_vitamins|amod|START_ENTITY intakes|nmod|B_vitamins Polymorphisms|appos|intakes Polymorphisms|nmod|gene gene|appos|END_ENTITY	Polymorphisms in the methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene , intakes of folate and related B_vitamins and colorectal_cancer : a case-control study in a population with relatively low folate intake .
18070159	0	folate	76,82	MTHFR	41,46	folate	MTHFR	MESH:D005492	4524	Chemical	Gene	intake|compound|START_ENTITY polymorphisms|dobj|intake polymorphisms|nsubj|association association|nmod|C677T C677T|compound|END_ENTITY	The association between mother and child MTHFR C677T polymorphisms , dietary folate intake and childhood atopy in a population-based , longitudinal birth cohort .
18480590	0	folate	6,12	MTHFR	54,59	folate	MTHFR	MESH:D005492	4524	Chemical	Gene	START_ENTITY|dobj|polymorphism polymorphism|appos|END_ENTITY	Serum folate and methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- C677T polymorphism adjusted for folate intake .
18480590	0	folate	93,99	MTHFR	54,59	folate	MTHFR	MESH:D005492	4524	Chemical	Gene	intake|amod|START_ENTITY adjusted|nmod|intake polymorphism|acl|adjusted polymorphism|appos|END_ENTITY	Serum folate and methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- C677T polymorphism adjusted for folate intake .
18616826	0	folate	122,128	MTHFR	37,42	folate	MTHFR	MESH:D005492	4524	Chemical	Gene	status|amod|START_ENTITY discussion|nmod|status polymorphisms|dep|discussion polymorphisms|amod|Methylenetetrahydrofolate_reductase Methylenetetrahydrofolate_reductase|dep|END_ENTITY	Methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene polymorphisms resulting in suboptimal oocyte maturation : a discussion of folate status , neural_tube_defects , schizophrenia , and vasculopathy .
19063701	0	folate	26,32	MTHFR	76,81	folate	MTHFR	MESH:D005492	4524	Chemical	Gene	reductase|amod|START_ENTITY reductase|appos|END_ENTITY	Serum total homocysteine , folate , 5,10-methylenetetrahydrofolate _ reductase -LRB- MTHFR -RRB- 677C -- > T genotype and subclinical atherosclerosis .
19178787	0	folate	53,59	MTHFR	9,14	folate	MTHFR	MESH:D005492	4524	Chemical	Gene	intake|nmod|START_ENTITY END_ENTITY|dep|intake	Maternal MTHFR 677C > T genotype and dietary intake of folate and vitamin_B -LRB- 12 -RRB- : their impact on child neurodevelopment .
19225123	0	folate	77,83	MTHFR	9,14	folate	MTHFR	MESH:D005492	4524	Chemical	Gene	affect|nmod|START_ENTITY affect|nsubj|END_ENTITY	Does the MTHFR 677C -- > T variant affect the Recommended Dietary Allowance for folate in the US population ?
19557016	0	folate	29,35	MTHFR	0,5	folate	MTHFR	MESH:D005492	4524	Chemical	Gene	intake|compound|START_ENTITY polymorphisms|appos|intake polymorphisms|amod|END_ENTITY	MTHFR polymorphisms , dietary folate intake and breast_cancer risk in Chinese women .
19577428	0	folate	8,14	MTHFR	113,118	folate	MTHFR	MESH:D005492	4524	Chemical	Gene	intake|amod|START_ENTITY decreases|nsubj|intake decreases|dobj|risk risk|nmod|carriers carriers|amod|susceptible susceptible|dep|END_ENTITY	Dietary folate and vitamin_B12 intake before diagnosis decreases gastric_cancer mortality risk among susceptible MTHFR 677TT carriers .
19660149	0	folate	42,48	MTHFR	111,116	folate	MTHFR	MESH:D005492	4524	Chemical	Gene	intake|compound|START_ENTITY genotype|nsubj|intake genotype|dep|END_ENTITY	Body composition at age 9 years , maternal folate intake during pregnancy and methyltetrahydrofolate_reductase -LRB- MTHFR -RRB- C677T genotype .
19759169	0	folate	44,50	MTHFR	87,92	folate	MTHFR	MESH:D005492	4524	Chemical	Gene	START_ENTITY|nmod|women women|nmod|allele allele|compound|END_ENTITY	Increased breast_cancer risk at high plasma folate concentrations among women with the MTHFR 677T allele .
19954067	0	folate	30,36	MTHFR	1,6	folate	MTHFR	MESH:D005492	4524	Chemical	Gene	polymorphisms|dep|START_ENTITY polymorphisms|nsubj|END_ENTITY	-LSB- MTHFR polymorphisms , dietary folate intake and risks to breast_cancer -RSB- .
21090237	0	folate	25,31	MTHFR	69,74	folate	MTHFR	MESH:D005492	4524	Chemical	Gene	genes|amod|START_ENTITY variants|nmod|genes variants|dep|END_ENTITY	-LSB- Polymorphic variants of folate metabolizing genes -LRB- C677T and A1298C MTHFR , C1420T SHMT1 and G1958A MTHFD -RRB- are not associated with the risk of breast_cancer in West Siberian Region of Russia -RSB- .
21375764	0	folate	5,11	MTHFR	58,63	folate	MTHFR	MESH:D005492	4524	Chemical	Gene	START_ENTITY|appos|methylation methylation|nmod|C677T C677T|compound|END_ENTITY	Diet folate , DNA methylation and genetic polymorphisms of MTHFR C677T in association with the prognosis of esophageal_squamous_cell_carcinoma .
21508090	0	folate	42,48	MTHFR	0,5	folate	MTHFR	MESH:D005492	4524	Chemical	Gene	concentrations|amod|START_ENTITY associated|nmod|concentrations associated|dep|END_ENTITY	MTHFR 677C - > T genotype is associated with folate and homocysteine concentrations in a large , population-based , double-blind trial of folic_acid supplementation .
21731042	0	folate	113,119	MTHFR	34,39	folate	MTHFR	MESH:D005492	4524	Chemical	Gene	requirements|amod|START_ENTITY implications|nmod|requirements Increase|dep|implications Increase|nmod|prevalence prevalence|nmod|polymorphism polymorphism|compound|END_ENTITY	Increase in the prevalence of the MTHFR 677 TT polymorphism in women born since 1959 : potential implications for folate requirements .
21803414	0	folate	42,48	MTHFR	76,81	folate	MTHFR	MESH:D005492	4524	Chemical	Gene	START_ENTITY|nmod|association association|nmod|genotype genotype|amod|END_ENTITY	Effect modification by population dietary folate on the association between MTHFR genotype , homocysteine , and stroke risk : a meta-analysis of genetic studies and randomised trials .
22367721	0	folate	7,13	MTHFR	52,57	folate	MTHFR	MESH:D005492	4524	Chemical	Gene	START_ENTITY|appos|methylenetetrahydrofolate_reductase methylenetetrahydrofolate_reductase|appos|END_ENTITY	Plasma folate , methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- , and colorectal_cancer risk in three large nested case-control studies .
23096011	0	folate	34,40	MTHFR	56,61	folate	MTHFR	MESH:D005492	4524	Chemical	Gene	START_ENTITY|nmod|groups groups|compound|END_ENTITY	Quantitation of whole-blood total folate within defined MTHFR C677T genotype groups by isotope dilution-liquid chromatography-tandem mass spectrometry differs from microbiologic assay .
23612630	0	folate	26,32	MTHFR	0,5	folate	MTHFR	MESH:D005492	4524	Chemical	Gene	polymorphism|amod|START_ENTITY polymorphism|compound|END_ENTITY	MTHFR C677T polymorphism , folate , vitamin_B12 and homocysteine in recurrent_pregnancy_losses : a case control study among North Indian women .
23807201	0	folate	27,33	MTHFR	0,5	folate	MTHFR	MESH:D005492	4524	Chemical	Gene	status|amod|START_ENTITY polymorphism|appos|status polymorphism|compound|END_ENTITY	MTHFR C677T polymorphism , folate status and colon_cancer risk in acromegalic patients .
24301776	0	folate	108,114	MTHFR	10,15	folate	MTHFR	MESH:D005492	4524	Chemical	Gene	levels|compound|START_ENTITY China|nmod|levels polymorphisms|nmod|China polymorphisms|nsubj|Impact Impact|nmod|END_ENTITY	Impact of MTHFR polymorphisms on methylation of MGMT in glioma patients from Northeast China with different folate levels .
24393513	0	folate	6,12	MTHFR	14,19	folate	MTHFR	MESH:D005492	4524	Chemical	Gene	polymorphism|amod|START_ENTITY polymorphism|amod|END_ENTITY	Serum folate , MTHFR C677T polymorphism and esophageal_squamous_cell_carcinoma risk .
26497154	0	folate	41,47	MTHFR	14,19	folate	MTHFR	MESH:D005492	4524	Chemical	Gene	markers|amod|START_ENTITY genotypes|nmod|markers impact|dep|genotypes impact|nmod|END_ENTITY	The impact of MTHFR 677_C / T genotypes on folate status markers : a meta-analysis of folic_acid intervention studies .
17446347	0	folate	69,75	PCFT	33,37	folate	PCFT	MESH:D005492	113235	Chemical	Gene	transporter|compound|START_ENTITY coding|nmod|transporter basis|advcl|coding basis|nsubj|spectrum spectrum|nmod|mutations mutations|nmod|gene gene|amod|END_ENTITY	The spectrum of mutations in the PCFT gene , coding for an intestinal folate transporter , that are the basis for hereditary_folate_malabsorption .
21058067	0	folate	15,21	PCFT	35,39	folate	PCFT	MESH:D005492	417569(Tax:9031)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Proton-coupled folate transporter -LRB- PCFT -RRB- : molecular cloning , tissue expression patterns and the effects of dietary folate supplementation on mRNA expression in laying hens .
23212123	0	folate	85,91	PCFT	105,109	folate	PCFT	MESH:D005492	52466(Tax:10090)	Chemical	Gene	barrier|nmod|START_ENTITY P-glycoprotein|nmod|barrier regulation|nmod|P-glycoprotein transporter|nsubj|regulation transporter|dobj|mice mice|appos|END_ENTITY	Functional regulation of P-glycoprotein at the blood-brain barrier in proton-coupled folate transporter -LRB- PCFT -RRB- mutant mice .
18174275	0	folate	100,106	PCFT/HCP1	31,40	folate	PCFT/HCP1	MESH:D005492	303333(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|characterization characterization|nmod|END_ENTITY	Functional characterization of PCFT/HCP1 as the molecular entity of the carrier-mediated intestinal folate transport system in the rat model .
9161403	0	folate	83,89	RFC-1	61,66	folate	RFC-1	MESH:D005492	19687(Tax:10090)	Chemical	Gene	transporter|amod|START_ENTITY encoding|dobj|transporter gene|acl|encoding gene|compound|END_ENTITY	Organization , structure and alternate splicing of the murine RFC-1 gene encoding a folate transporter .
9602167	0	folate	55,61	RFC-1	33,38	folate	RFC-1	MESH:D005492	5981	Chemical	Gene	transporter|amod|START_ENTITY encoding|dobj|transporter gene|acl|encoding gene|compound|END_ENTITY	Structural analysis of the human RFC-1 gene encoding a folate transporter reveals multiple promoters and alternatively spliced transcripts with 5 ' end heterogeneity .
18053808	0	folate	125,131	SLC19A1	24,31	folate	SLC19A1	MESH:D005492	6573	Chemical	Gene	levels|compound|START_ENTITY T|nmod|levels polymorphism|dobj|T polymorphism|nsubj|association association|nmod|C C|compound|END_ENTITY	Distinct association of SLC19A1 polymorphism -43 T > C with red cell folate levels and of MTHFR polymorphism 677C > T with plasma folate levels .
18053808	0	folate	66,72	SLC19A1	24,31	folate	SLC19A1	MESH:D005492	6573	Chemical	Gene	levels|compound|START_ENTITY C|nmod|levels C|compound|END_ENTITY	Distinct association of SLC19A1 polymorphism -43 T > C with red cell folate levels and of MTHFR polymorphism 677C > T with plasma folate levels .
19650776	0	folate	12,18	SLC19A1	28,35	folate	SLC19A1	MESH:D005492	6573	Chemical	Gene	carrier|compound|START_ENTITY carrier|appos|END_ENTITY	The reduced folate carrier -LRB- SLC19A1 -RRB- c. 80G > A polymorphism is associated with red cell folate concentrations among women .
19650776	0	folate	86,92	SLC19A1	28,35	folate	SLC19A1	MESH:D005492	6573	Chemical	Gene	concentrations|compound|START_ENTITY associated|nmod|concentrations >|acl:relcl|associated c.|dobj|> c.|nsubj|carrier carrier|appos|END_ENTITY	The reduced folate carrier -LRB- SLC19A1 -RRB- c. 80G > A polymorphism is associated with red cell folate concentrations among women .
20683905	0	folate	65,71	SLC19A1	81,88	folate	SLC19A1	MESH:D005492	6573	Chemical	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Association of folate receptor -LRB- FOLR1 , FOLR2 , FOLR3 -RRB- and reduced folate carrier -LRB- SLC19A1 -RRB- genes with meningomyelocele .
24745983	0	folate	34,40	SLC19A1	54,61	folate	SLC19A1	MESH:D005492	6573	Chemical	Gene	Biology|nmod|START_ENTITY transporters|nsubj|Biology transporters|dobj|END_ENTITY	Biology of the major facilitative folate transporters SLC19A1 and SLC46A1 .
17898134	0	folate	18,24	SLC46A1	39,46	folate	SLC46A1	MESH:D005492	113235	Chemical	Gene	transporters|compound|START_ENTITY transporters|appos|END_ENTITY	Rodent intestinal folate transporters -LRB- SLC46A1 -RRB- : secondary structure , functional properties , and response to dietary folate restriction .
18782461	0	folate	44,50	SLC46A1	87,94	folate	SLC46A1	MESH:D005492	52466(Tax:10090)	Chemical	Gene	carrier_protein_1|compound|START_ENTITY carrier_protein_1|appos|END_ENTITY	Haem and folate transport by proton-coupled folate transporter/haem _ carrier_protein_1 -LRB- SLC46A1 -RRB- .
19389703	0	folate	58,64	SLC46A1	146,153	folate	SLC46A1	MESH:D005492	113235	Chemical	Gene	translocation|compound|START_ENTITY roles|nmod|translocation mediated|nsubj|roles mediated|nmod|END_ENTITY	The functional roles of the His247 and His281 residues in folate and proton translocation mediated by the human proton-coupled folate transporter SLC46A1 .
20724482	0	folate	26,32	SLC46A1	51,58	folate	SLC46A1	MESH:D005492	113235	Chemical	Gene	PCFT|compound|START_ENTITY PCFT|appos|END_ENTITY	The obligatory intestinal folate transporter PCFT -LRB- SLC46A1 -RRB- is regulated by nuclear_respiratory_factor_1 .
26789141	0	folate	29,35	SLC46A1	49,56	folate	SLC46A1	MESH:D005492	113235	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Evaluation of proton-coupled folate transporter -LRB- SLC46A1 -RRB- polymorphisms as risk factors for neural_tube_defects and oral_clefts .
18400109	0	folate	36,42	Slc19a1	58,65	folate	Slc19a1	MESH:D005492	6573	Chemical	Gene	carrier|amod|START_ENTITY carrier|appos|RFC1 RFC1|dep|END_ENTITY	Microarray analysis of E9 .5 reduced folate carrier -LRB- RFC1 ; Slc19a1 -RRB- knockout embryos reveals altered expression of genes in the cubilin-megalin multiligand endocytic receptor complex .
3839013	0	folate	14,20	conjugase	21,30	folate	conjugase	MESH:D005492	25455(Tax:10116)	Chemical	Gene	activities|amod|START_ENTITY activities|compound|END_ENTITY	Comparison of folate conjugase activities in human , pig , rat and monkey intestine .
6548957	0	folate	11,17	conjugase	18,27	folate	conjugase	MESH:D005492	25455(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|activity activity|amod|END_ENTITY	Intestinal folate conjugase activity and folate absorption in the ethanol-fed pregnant rat .
10962643	0	folate	31,37	dihydrofolate_reductase	62,85	folate	dihydrofolate reductase	MESH:D005492	1719	Chemical	Gene	analog|amod|START_ENTITY analog|nmod|END_ENTITY	Interaction energy analyses of folate analog binding to human dihydrofolate_reductase : contribution of the antifolate substructural regions to complex stability .
16969375	0	folate	136,142	dihydrofolate_reductase	40,63	folate	dihydrofolate reductase	MESH:D005492	1719	Chemical	Gene	levels|amod|START_ENTITY relation|nmod|levels analysis|dep|relation analysis|nmod|gene gene|compound|END_ENTITY	Molecular genetic analysis of the human dihydrofolate_reductase gene : relation with plasma total homocysteine , serum and red blood cell folate levels .
18247058	0	folate	122,128	dihydrofolate_reductase	42,65	folate	dihydrofolate reductase	MESH:D005492	1719	Chemical	Gene	concentrations|amod|START_ENTITY associated|nmod|concentrations associated|nsubjpass|polymorphism polymorphism|nmod|gene gene|amod|END_ENTITY	An insertion/deletion polymorphism of the dihydrofolate_reductase -LRB- DHFR -RRB- gene is associated with serum and red blood cell folate concentrations in women .
2248959	0	folate	79,85	dihydrofolate_reductase	40,63	folate	dihydrofolate reductase	MESH:D005492	1719	Chemical	Gene	complexed|advcl|START_ENTITY complexed|nsubj|structures structures|nmod|END_ENTITY	Crystal structures of recombinant human dihydrofolate_reductase complexed with folate and 5-deazafolate .
2633609	0	folate	40,46	dihydrofolate_reductase	101,124	folate	dihydrofolate reductase	MESH:D005492	24312(Tax:10116)	Chemical	Gene	depletion|amod|START_ENTITY characteristics|nmod|depletion characteristics|acl|vitro vitro|nmod|inhibition inhibition|nmod|END_ENTITY	The characteristics and consequences of folate depletion in hepatoma cells in vitro by inhibition of dihydrofolate_reductase .
26482924	0	folate	98,104	dihydrofolate_reductase	57,80	folate	dihydrofolate reductase	MESH:D005492	13906554	Chemical	Gene	complex|amod|START_ENTITY mutant|amod|complex END_ENTITY|dobj|mutant	Sequential backbone resonance assignments of the E. _ coli dihydrofolate_reductase Gly67Val mutant : folate complex .
3630970	0	folate	26,32	dihydrofolate_reductase	47,70	folate	dihydrofolate reductase	MESH:D005492	1719	Chemical	Gene	absorption|amod|START_ENTITY inhibition|nmod|absorption inhibition|nmod|inhibitors inhibitors|amod|END_ENTITY	Competitive inhibition of folate absorption by dihydrofolate_reductase inhibitors , trimethoprim and pyrimethamine .
6860674	1	folate	116,122	dihydrofolate_reductase	138,161	folate	dihydrofolate reductase	MESH:D005492	1719	Chemical	Gene	reaction|nmod|START_ENTITY Implications|nmod|reaction analogues|nsubj|Implications analogues|nmod|END_ENTITY	Implications for the reaction of folate analogues with dihydrofolate_reductase .
8334117	0	folate	65,71	dihydrofolate_reductase	114,137	folate	dihydrofolate reductase	MESH:D005492	1719	Chemical	Gene	states|nmod|START_ENTITY determination|nmod|states END_ENTITY|nsubj|determination	13C NMR determination of the tautomeric and ionization states of folate in its complexes with Lactobacillus casei dihydrofolate_reductase .
8449831	0	folate	112,118	dihydrofolate_reductase	28,51	folate	dihydrofolate reductase	MESH:D005492	1719	Chemical	Gene	analogues|compound|START_ENTITY resistant|nmod|analogues made|xcomp|resistant made|nsubj|alterations alterations|nmod|gene gene|amod|END_ENTITY	Differential alterations of dihydrofolate_reductase gene in human leukemia cell lines made resistant to various folate analogues .
8634297	0	folate	28,34	dihydrofolate_reductase	40,63	folate	dihydrofolate reductase	MESH:D005492	13906554	Chemical	Gene	specificity|nmod|START_ENTITY specificity|nmod|END_ENTITY	Engineering specificity for folate into dihydrofolate_reductase from Escherichia_coli .
8934221	0	folate	29,35	dihydrofolate_reductase	72,95	folate	dihydrofolate reductase	MESH:D005492	13361(Tax:10090)	Chemical	Gene	analogs|amod|START_ENTITY effects|nmod|analogs effects|dep|implications implications|acl|using using|dobj|gene gene|amod|END_ENTITY	The hematological effects of folate analogs : implications for using the dihydrofolate_reductase gene for in vivo selection .
9037186	0	folate	57,63	dihydrofolate_reductase	93,116	folate	dihydrofolate reductase	MESH:D005492	1719	Chemical	Gene	forms|nmod|START_ENTITY aspartate|nmod|forms influence|nmod|aspartate bound|nsubj|influence bound|nmod|END_ENTITY	The influence of aspartate 26 on the tautomeric forms of folate bound to Lactobacillus casei dihydrofolate_reductase .
2552922	0	folate	56,62	folate_binding_protein	32,54	folate	folate binding protein	MESH:D005492	2348	Chemical	Gene	receptor|amod|START_ENTITY Role|appos|receptor Role|nmod|END_ENTITY	Role of the membrane-associated folate_binding_protein -LRB- folate receptor -RRB- in methotrexate transport by human KB cells .
26116148	0	folate	105,111	folate_binding_protein	81,103	folate	folate binding protein	MESH:D005492	2348	Chemical	Gene	receptor|amod|START_ENTITY END_ENTITY|appos|receptor	The complex interplay between ligand binding and conformational structure of the folate_binding_protein -LRB- folate receptor -RRB- : Biological perspectives .
14565618	0	folate	65,71	folate_binding_protein-1	82,106	folate	folate binding protein-1	MESH:D005492	14275(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|dep|END_ENTITY	Antisense modulation of the coding or regulatory sequence of the folate receptor -LRB- folate_binding_protein-1 -RRB- in mouse embryos leads to neural_tube_defects .
3838667	0	folate	54,60	glycine_N-methyltransferase	14,41	folate	glycine N-methyltransferase	MESH:D005492	25134(Tax:10116)	Chemical	Gene	derivatives|amod|START_ENTITY activity|nmod|derivatives activity|amod|END_ENTITY	Inhibition of glycine_N-methyltransferase activity by folate derivatives : implications for regulation of methyl group metabolism .
19762432	0	folate	25,31	hPCFT	45,50	folate	hPCFT	MESH:D005492	113235	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	The human proton-coupled folate transporter -LRB- hPCFT -RRB- : modulation of intestinal expression and function by drugs .
18256483	0	folate	125,131	heme_carrier_protein_1	89,111	folate	heme carrier protein 1	MESH:D005492	113235	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|nmod|transport	The mechanism of carrier-mediated transport of folates in BeWo cells : the involvement of heme_carrier_protein_1 in placental folate transport .
25877470	1	folate	208,214	human	187,192	folate	hPCFT	MESH:D005492	113235	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	The human proton-coupled folate transporter -LRB- hPCFT -RRB- is expressed in solid tumours and is active at pHs characterizing the tumour microenvironment .
24714357	0	folate	22,28	interferon-a	109,121	folate	interferon-a	MESH:D005492	3440	Chemical	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	A Phase I/Ib study of folate immune -LRB- EC90 vaccine administered with GPI-0100 adjuvant followed by EC17 -RRB- with interferon-a and interleukin-2 in patients with renal_cell_carcinoma .
10633085	0	folate	15,21	lyn	56,59	folate	lyn	MESH:D005492	4067	Chemical	Gene	receptor|amod|START_ENTITY receptor|nmod|END_ENTITY	Interaction of folate receptor with signaling molecules lyn and G -LRB- alpha -RRB- -LRB- i-3 -RRB- in detergent-resistant complexes from the ovary_carcinoma cell line IGROV1 .
10397696	0	folate	4,10	methylenetetrahydrofolate_reductase	35,70	folate	methylenetetrahydrofolate reductase	MESH:D005492	4524	Chemical	Gene	levels|amod|START_ENTITY END_ENTITY|nsubj|levels	Low folate levels and thermolabile methylenetetrahydrofolate_reductase as primary determinant of mild hyperhomocystinemia in normal and thromboembolic subjects .
19152916	0	folate	115,121	monocyte_chemoattractant_protein-1	21,55	folate	monocyte chemoattractant protein-1	MESH:D005492	6347	Chemical	Gene	stress|compound|START_ENTITY MCP-1|nmod|stress MCP-1|amod|END_ENTITY	The up-regulation of monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- in Ea.hy 926 endothelial cells under long-term low folate stress is mediated by the p38 MAPK pathway .
21765609	0	folate	29,35	monocyte_chemoattractant_protein-1	54,88	folate	monocyte chemoattractant protein-1	MESH:D005492	6347	Chemical	Gene	START_ENTITY|dobj|intake intake|amod|END_ENTITY	Relationship between dietary folate intake and plasma monocyte_chemoattractant_protein-1 and interleukin-8 in heart_failure patients .
15205349	0	folate	107,113	p53	154,157	folate	p53	MESH:D005492	7157	Chemical	Gene	START_ENTITY|nmod|cells cells|nmod|END_ENTITY	p14ARF expression increases dihydrofolate_reductase degradation and paradoxically results in resistance to folate antagonists in cells with nonfunctional p53 .
17079455	0	folate	12,18	polo-like_kinase_1	110,128	folate	polo-like kinase 1	MESH:D005492	18817(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Low dietary folate initiates intestinal_tumors in mice , with altered expression of G2-M checkpoint regulators polo-like_kinase_1 and cell division cycle 25c .
11642607	0	folate	9,15	prostate-specific_membrane_antigen	27,61	folate	prostate-specific membrane antigen	MESH:D005492	2346	Chemical	Gene	hydrolase|compound|START_ENTITY hydrolase|appos|END_ENTITY	A unique folate hydrolase , prostate-specific_membrane_antigen -LRB- PSMA -RRB- : a target for immunotherapy ?
24190584	0	folate	27,33	proton-coupled_folate_transporter	75,108	folate	proton-coupled folate transporter	MESH:D005492	52466(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|expression expression|nmod|END_ENTITY	Vitamin_D is not linked to folate status and mRNA expression of intestinal proton-coupled_folate_transporter .
19371039	0	folate	173,179	reduced_folate_carrier	199,221	folate	reduced folate carrier	MESH:D005492	6573	Chemical	Gene	receptors|compound|START_ENTITY receptors|nmod|END_ENTITY	Synthesis and biological activity of a novel series of 6-substituted_thieno -LSB- 2,3-d -RSB- pyrimidine antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors over the reduced_folate_carrier and proton-coupled_folate_transporter for cellular entry .
25959374	8	folic_acid	1075,1085	APP	1120,1123	folic acid	APP	MESH:D005492	11820(Tax:10090)	Chemical	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	DNA methylation rate was stimulated by folic_acid in the amyloid precursor protein -LRB- APP -RRB- promoter and in the presenilin_1 -LRB- PS1 -RRB- promoter .
15786529	0	folic_acid	11,21	Bcl-2	64,69	folic acid	Bcl-2	MESH:D005492	596	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of folic_acid on epithelial apoptosis and expression of Bcl-2 and p53 in premalignant_gastric_lesions .
19660435	0	folic_acid	107,117	FT1	93,96	folic acid	FT1	MESH:D005492	64400	Chemical	Gene	transporter|amod|START_ENTITY END_ENTITY|appos|transporter	Structure-function analysis of the highly conserved charged residues of the membrane protein FT1 , the main folic_acid transporter of the protozoan parasite Leishmania .
23803214	0	folic_acid	11,21	HOXA10	100,106	folic acid	HOXA10	MESH:D005492	3206	Chemical	Gene	-RSB-|amod|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Effect of folic_acid in preventing aberrant methylation of fetal endometriosis susceptibility gene HOXA10 -RSB- .
15354385	0	folic_acid	26,36	MTHFR	0,5	folic acid	MTHFR	MESH:D005492	4524	Chemical	Gene	polymorphism|appos|START_ENTITY polymorphism|compound|END_ENTITY	MTHFR C677T polymorphism , folic_acid and hyperhomocysteinemia in levodopa treated patients with Parkinson 's _ disease .
14704292	0	folic_acid	56,66	Methylenetetrahydrofolate_reductase	0,35	folic acid	Methylenetetrahydrofolate reductase	MESH:D005492	4524	Chemical	Gene	polymorphism|amod|START_ENTITY polymorphism|compound|END_ENTITY	Methylenetetrahydrofolate_reductase C677T polymorphism , folic_acid and riboflavin are important determinants of genome stability in cultured human lymphocytes .
24823794	0	folic_acid	87,97	NAT1	124,128	folic acid	NAT1	MESH:D005492	9	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	From arylamine_N-acetyltransferase to folate-dependent acetyl_CoA hydrolase : impact of folic_acid on the activity of -LRB- HUMAN -RRB- NAT1 and its homologue -LRB- MOUSE -RRB- NAT2 .
22037925	0	folic_acid	75,85	PI3K	15,19	folic acid	PI3K	MESH:D005492	18708(Tax:10090)	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of PI3K , GSK-3b and PPARy in the antidepressant-like effect of folic_acid in the forced swimming test in mice .
11508713	0	folic_acid	53,63	dihydrofolate_reductase	14,37	folic acid	dihydrofolate reductase	MESH:D005492	100525912	Chemical	Gene	activities|nmod|START_ENTITY activities|amod|END_ENTITY	Comparison of dihydrofolate_reductase activities for folic_acid in pigs and rats using in vivo and in vitro evaluation techniques .
19706381	0	folic_acid	113,123	dihydrofolate_reductase	44,67	folic acid	dihydrofolate reductase	MESH:D005492	1719	Chemical	Gene	START_ENTITY|nsubj|activity activity|nmod|END_ENTITY	The extremely slow and variable activity of dihydrofolate_reductase in human liver and its implications for high folic_acid intake .
14608093	0	folic_acid	20,30	folate-binding_protein	97,119	folic acid	folate-binding protein	MESH:D005492	2348	Chemical	Gene	Bioaccessibility|nmod|START_ENTITY Bioaccessibility|dep|decreases decreases|nmod|addition addition|nmod|END_ENTITY	Bioaccessibility of folic_acid and -LRB- 6S -RRB- -5 - methyltetrahydrofolate decreases after the addition of folate-binding_protein to yogurt as studied in a dynamic in vitro gastrointestinal model .
6165215	0	folic_acid	86,96	folate-binding_protein	12,34	folic acid	folate-binding protein	MESH:D005492	2348	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of a folate-binding_protein on the plasma transport and tissue distribution of folic_acid .
18313674	0	folic_acid	10,20	insulin	47,54	folic acid	insulin	MESH:D005492	3630	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	Effect of folic_acid in women with and without insulin resistance who have hyperhomocysteinemic_polycystic_ovary_syndrome .
16377938	0	folic_acid	11,21	matrix_metalloproteinase-2	92,118	folic acid	matrix metalloproteinase-2	MESH:D005492	81686(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	Effects of folic_acid and magnesium on the production of homocysteine-induced extracellular matrix_metalloproteinase-2 in cultured rat vascular smooth muscle cells .
20090312	0	folic_acid	19,29	myelin_basic_protein	51,71	folic acid	myelin basic protein	MESH:D005492	24547(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effects of dietary folic_acid on the expression of myelin_basic_protein in the brain and spinal cord of pregnant and lactating rats .
21125813	0	folic_acid	14,24	tumor_necrosis_factor_alpha	28,55	folic acid	tumor necrosis factor alpha	MESH:D005492	24835(Tax:10116)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition by folic_acid of tumor_necrosis_factor_alpha and apoptosis following normothermic ischemia-reperfusion .
1532671	0	folinic_acid	10,22	thymidylate_synthase	66,86	folinic acid	thymidylate synthase	MESH:D002955	22171(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of folinic_acid on fluorouracil activity and expression of thymidylate_synthase .
18691909	0	follistatin	20,31	BMP	4,7	follistatin	BMP	null	649	Chemical	Gene	antagonists|dobj|START_ENTITY antagonists|nsubj|END_ENTITY	The BMP antagonists follistatin and gremlin in normal and early osteoarthritic cartilage : an immunohistochemical study .
10395734	6	follistatin	1126,1137	cAMP	1112,1116	follistatin	LH-R	null	25477(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	Since FSH and cAMP increase follistatin production in granulosa cells , we examined the effect of follistatin on LH-R induction in the presence of activin and FSH .
22033906	0	follistatin	78,89	myostatin	65,74	follistatin	myostatin	null	29152(Tax:10116)	Chemical	Gene	ratio|acl|START_ENTITY ratio|nmod|END_ENTITY	A potential indicator of denervated muscle_atrophy : the ratio of myostatin to follistatin in peripheral blood .
12521235	0	follitropin	60,71	sex_hormone-binding_globulin	120,148	follitropin	sex hormone-binding globulin	MESH:D005640	6462	Chemical	Gene	lutropin|appos|START_ENTITY lutropin|amod|END_ENTITY	Reference ranges for serum concentrations of lutropin -LRB- LH -RRB- , follitropin -LRB- FSH -RRB- , estradiol -LRB- E2 -RRB- , prolactin , progesterone , sex_hormone-binding_globulin -LRB- SHBG -RRB- , dehydroepiandrosterone_sulfate -LRB- DHEAS -RRB- , cortisol and ferritin in neonates , children and young adults .
7565632	0	folyl	39,44	gamma-glutamyl_hydrolase	11,35	folyl	gamma-glutamyl hydrolase	null	8836	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of gamma-glutamyl_hydrolase on folyl and antifolylpolyglutamates in cultured H35 hepatoma cells .
24863754	0	folyl-poly-y-l-glutamate	51,75	glutamate_carboxypeptidase_II	106,135	folyl-poly-y-l-glutamate	glutamate carboxypeptidase II	null	2346	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Structural and biochemical characterization of the folyl-poly-y-l-glutamate hydrolyzing activity of human glutamate_carboxypeptidase_II .
9224825	0	folylpolyglutamate	15,33	synthetase_and_dihydrofolate_reductase	34,72	folylpolyglutamate	synthetase and dihydrofolate reductase	null	1719	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Differences in folylpolyglutamate synthetase_and_dihydrofolate_reductase expression in human B-lineage_versus_T-lineage_leukemic_lymphoblasts : mechanisms for lineage differences in methotrexate polyglutamylation and cytotoxicity .
10775560	0	fonsartan	55,64	angiotensin_II_type_1_receptor	10,40	fonsartan	angiotensin II type 1 receptor	MESH:C094626	81638(Tax:10116)	Chemical	Gene	blockade|nmod|START_ENTITY blockade|amod|END_ENTITY	Long-term angiotensin_II_type_1_receptor blockade with fonsartan doubles lifespan of hypertensive rats .
20472683	0	foretinib	19,28	c-Met	60,65	foretinib	c-Met	MESH:C544831	4233	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	A phase I study of foretinib , a multi-targeted inhibitor of c-Met and vascular endothelial growth factor receptor 2 .
12759105	0	formaldehyde	114,126	ADH3	142,146	formaldehyde	ADH3	MESH:D005557	11529(Tax:10090)	Chemical	Gene	dehydrogenase|compound|START_ENTITY dehydrogenase|appos|END_ENTITY	Methanol metabolism and embryotoxicity in rat and mouse conceptuses : comparisons of alcohol dehydrogenase -LRB- ADH1 -RRB- , formaldehyde dehydrogenase -LRB- ADH3 -RRB- , and catalase .
18669168	0	formaldehyde	11,23	CD4	38,41	formaldehyde	CD4	MESH:D005557	24932(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|cells cells|amod|END_ENTITY	Effects of formaldehyde and xylene on CD4 - and CD8-positive T cells in bronchus-associated lymphoid tissue in rats .
24281847	0	formaldehyde	41,53	CO2	59,62	formaldehyde	CO2	MESH:D005557	717	Chemical	Gene	production|nmod|START_ENTITY production|nmod|END_ENTITY	High-yield electrochemical production of formaldehyde from CO2 and seawater .
19847360	0	formaldehyde	109,121	TRPV1	42,47	formaldehyde	TRPV1	MESH:D005557	83810(Tax:10116)	Chemical	Gene	neurons|nmod|START_ENTITY neurons|nsubj|roles roles|nmod|END_ENTITY	Mediating roles of the vanilloid receptor TRPV1 in activation of rat primary afferent nociceptive neurons by formaldehyde .
2721477	0	formaldehyde	25,37	cytochrome_P450	50,65	formaldehyde	cytochrome P450	MESH:D005557	25251(Tax:10116)	Chemical	Gene	influence|nmod|START_ENTITY influence|nmod|END_ENTITY	The influence of inhaled formaldehyde on rat lung cytochrome_P450 .
8100769	0	formaldehyde	45,57	cytochrome_P450	10,25	formaldehyde	cytochrome P450	MESH:D005557	25251(Tax:10116)	Chemical	Gene	vapor|compound|START_ENTITY exposed|nmod|vapor exposed|nsubj|END_ENTITY	Pulmonary cytochrome_P450 in rats exposed to formaldehyde vapor .
1631902	0	formaldehyde	26,38	semicarbazide-sensitive_amine_oxidase	51,88	formaldehyde	semicarbazide-sensitive amine oxidase	MESH:D005557	29473(Tax:10116)	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|nmod|END_ENTITY	Methylamine metabolism to formaldehyde by vascular semicarbazide-sensitive_amine_oxidase .
17899221	0	formaldehyde_ferredoxin	72,95	oxidoreductase	96,110	formaldehyde ferredoxin	oxidoreductase	null	7296	Chemical	Gene	study|nmod|START_ENTITY END_ENTITY|nsubj|study	A steady-state and pre-steady-state kinetics study of the tungstoenzyme formaldehyde_ferredoxin oxidoreductase from Pyrococcus furiosus .
18824219	0	formalin	91,99	26RFa	48,53	formalin	26RFa	MESH:D005557	379044(Tax:10116)	Chemical	Gene	test|compound|START_ENTITY END_ENTITY|nmod|test	Analgesic effects of intrathecally administered 26RFa , an intrinsic agonist for GPR103 , on formalin test and carrageenan test in rats .
21300038	0	formalin	35,43	CRH	8,11	formalin	CRH	MESH:D005557	81648(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|changes changes|compound|END_ENTITY	Central CRH administration changes formalin pain responses in male and female rats .
19427893	0	formalin	51,59	MKK3	0,4	formalin	MKK3	MESH:D005557	26397(Tax:10090)	Chemical	Gene	contributes|xcomp|START_ENTITY contributes|nsubj|END_ENTITY	MKK3 , an upstream activator of p38 , contributes to formalin phase 2 and late allodynia in mice .
17556846	0	formalin	22,30	Prolactin	0,9	formalin	Prolactin	MESH:D005557	24683(Tax:10116)	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Prolactin response to formalin is related to the acute nociceptive response and it is attenuated by combined application of different stressors .
10593203	0	formalin	11,19	c-Fos	40,45	formalin	c-Fos	MESH:D005557	314322(Tax:10116)	Chemical	Gene	pain|compound|START_ENTITY Effects|nmod|pain Effects|nmod|expression expression|amod|END_ENTITY	Effects of formalin pain on hippocampal c-Fos expression in male and female rats .
11698319	0	formalin	66,74	c-Fos	82,87	formalin	c-Fos	MESH:D005557	314322(Tax:10116)	Chemical	Gene	evoked|nsubj|START_ENTITY evoked|dobj|expression expression|amod|END_ENTITY	Intrathecal pre-administration of fentanyl effectively suppresses formalin evoked c-Fos expression in spinal cord of rat .
15910798	0	formalin	69,77	c-Fos	92,97	formalin	c-Fos	MESH:D005557	314322(Tax:10116)	Chemical	Gene	model|compound|START_ENTITY F_13640|nmod|model agonist|appos|F_13640 Effects|nmod|agonist Effects|dep|study study|amod|END_ENTITY	Effects of the high-efficacy 5-HT1A receptor agonist , F_13640 in the formalin pain model : a c-Fos study .
16051541	0	formalin	175,183	c-Fos	0,5	formalin	c-Fos	MESH:D005557	314322(Tax:10116)	Chemical	Gene	test|compound|START_ENTITY using|dobj|test antisense|parataxis|using antisense|nsubj|END_ENTITY	c-Fos antisense oligodeoxynucleotide offsets behavioral nociceptive responses and both up-regulations of c-Fos protein and dynorphin a -LRB- 1-8 -RRB- in dorsal horn : a study using the formalin test in rats .
17331932	0	formalin	84,92	c-Fos	54,59	formalin	c-Fos	MESH:D005557	14281(Tax:10090)	Chemical	Gene	test|compound|START_ENTITY inhibits|nmod|test inhibits|dobj|expression expression|compound|END_ENTITY	Intrathecal landiolol inhibits nociception and spinal c-Fos expression in the mouse formalin test .
8593586	0	formalin	83,91	c-Fos	99,104	formalin	c-Fos	MESH:D005557	314322(Tax:10116)	Chemical	Gene	evoked|nsubj|START_ENTITY evoked|dobj|expression expression|amod|END_ENTITY	7-Nitro-indazole , a selective inhibitor of neuronal nitric_oxide synthase , reduces formalin evoked c-Fos expression in dorsal horn neurons of the rat spinal cord .
9330358	0	formalin	25,33	c-Fos	51,56	formalin	c-Fos	MESH:D005557	314322(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|amod|END_ENTITY	Sex-dependent effects of formalin and restraint on c-Fos expression in the septum and hippocampus of the rat .
16861438	0	formalin	90,98	c-fos	54,59	formalin	c-fos	MESH:D005557	14281(Tax:10090)	Chemical	Gene	injection|compound|START_ENTITY effects|nmod|injection effects|nmod|expression expression|compound|END_ENTITY	Propofol 's effects on nociceptive_behavior and spinal c-fos expression after intraplantar formalin injection in mice with a mutation in the gamma-aminobutyric_acid-type -LRB- A -RRB- receptor beta3 subunit .
8032900	0	formalin	61,69	c-fos	11,16	formalin	c-fos	MESH:D005557	314322(Tax:10116)	Chemical	Gene	stimulation|compound|START_ENTITY neurons|nmod|stimulation neurons|nsubj|Changes Changes|nmod|induction induction|amod|END_ENTITY	Changes in c-fos induction in dorsal horn neurons by hindpaw formalin stimulation following tibial neurotomy .
8672390	0	formalin	130,138	c-fos	54,59	formalin	c-fos	MESH:D005557	314322(Tax:10116)	Chemical	Gene	rat|nmod|START_ENTITY suppress|advcl|rat suppress|dobj|expression expression|amod|END_ENTITY	Nitrous_oxide or halothane , or both , fail to suppress c-fos expression in rat spinal cord dorsal horn neurones after subcutaneous formalin .
8916346	0	formalin	23,31	c-fos	0,5	formalin	c-fos	MESH:D005557	493935(Tax:9685)	Chemical	Gene	injection|compound|START_ENTITY expression|nmod|injection expression|nsubj|END_ENTITY	c-fos expression after formalin injection into the face in the cat .
9060019	0	formalin	51,59	c-fos	83,88	formalin	c-fos	MESH:D005557	314322(Tax:10116)	Chemical	Gene	test|compound|START_ENTITY test|nmod|pattern pattern|nmod|expression expression|amod|END_ENTITY	Differential contribution of the two phases of the formalin test to the pattern of c-fos expression in the rat spinal cord : studies with remifentanil and lidocaine .
6195915	0	formalin	14,22	carcinoembryonic_antigen	82,106	formalin	carcinoembryonic antigen	MESH:D005557	1084	Chemical	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|END_ENTITY	Comparison of formalin - and acetone-fixation for immunohistochemical detection of carcinoembryonic_antigen -LRB- CEA -RRB- and keratin .
25447449	0	formalin	106,114	neuropeptide_S	78,92	formalin	neuropeptide S	MESH:D005557	100043254(Tax:10090)	Chemical	Gene	test|compound|START_ENTITY END_ENTITY|nmod|test	Central adenosine A1 and A2A receptors mediate the antinociceptive effects of neuropeptide_S in the mouse formalin test .
14534783	0	formate	67,74	FDH1	48,52	formate	FDH1	MESH:C030544	854570(Tax:4932)	Chemical	Gene	boidinii|amod|START_ENTITY sufficient|nmod|boidinii sufficient|nmod|induction induction|nmod|expression expression|compound|END_ENTITY	Cis-acting elements sufficient for induction of FDH1 expression by formate in the methylotrophic yeast Candida boidinii .
9226256	0	formate	18,25	FDH1	46,50	formate	FDH1	MESH:C030544	854570(Tax:4932)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Regulation of the formate dehydrogenase gene , FDH1 , in the methylotrophic yeast Candida boidinii and growth characteristics of an FDH1-disrupted strain on methanol , methylamine , and choline .
15549291	0	formate	94,101	alcohol_dehydrogenase	135,156	formate	alcohol dehydrogenase	MESH:C030544	13909458	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|dep|END_ENTITY	Enantioselective reduction of carbonyl compounds by whole-cell biotransformation , combining a formate dehydrogenase and a -LRB- R -RRB- - specific alcohol_dehydrogenase .
8566699	0	formate	41,48	dehydrogenase	49,62	formate	dehydrogenase	MESH:C030544	2781506(Tax:882)	Chemical	Gene	Purification|nmod|START_ENTITY END_ENTITY|nsubj|Purification	Purification and characterization of the formate dehydrogenase from Desulfovibrio_vulgaris_Hildenborough .
24741672	0	formic_acid	48,59	CO2	73,76	formic acid	CO2	MESH:C030544	717	Chemical	Gene	oxidation|amod|START_ENTITY oxidation|nmod|END_ENTITY	Reversible potentials for steps in methanol and formic_acid oxidation to CO2 ; adsorption energies of intermediates on the ideal electrocatalyst for methanol oxidation and CO2 reduction .
20656782	0	formic_acid	87,98	Cj0952c	30,37	formic acid	Cj0952c	MESH:C030544	905245(Tax:192222)	Chemical	Gene	affect|nmod|START_ENTITY affect|nsubj|END_ENTITY	Campylobacter_jejuni proteins Cj0952c and Cj0951c affect chemotactic behaviour towards formic_acid and are important for invasion of host cells .
23408242	0	formic_acid	28,39	hCG	43,46	formic acid	hCG	MESH:C030544	3342	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Adverse placental effect of formic_acid on hCG secretion is mitigated by folic_acid .
22753406	0	formin	66,72	actin	52,57	formin	actin	null	850504(Tax:4932)	Chemical	Gene	regulation|compound|START_ENTITY regulation|compound|END_ENTITY	Thoracic_aortic_aneurysm -LRB- TAAD -RRB- - causing mutation in actin affects formin regulation of polymerization .
9525449	0	formoterol	90,100	Beta2-adrenoceptor	0,18	formoterol	Beta2-adrenoceptor	MESH:C012629	154	Chemical	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Beta2-adrenoceptor regulation and bronchodilator sensitivity after regular treatment with formoterol in subjects with stable asthma .
20156737	0	formoterol	54,64	HSP90	8,13	formoterol	HSP90	MESH:C012629	3320	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|END_ENTITY	Nuclear HSP90 and HSP70 in COPD patients treated with formoterol or formoterol and corticosteroids .
17229563	0	formoterol	10,20	IL-6	39,43	formoterol	IL-6	MESH:C012629	3569	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|release release|amod|END_ENTITY	Effect of formoterol and salmeterol on IL-6 and IL-8 release in airway epithelial cells .
22265022	0	formoterol	14,24	VEGF	39,43	formoterol	VEGF	MESH:C012629	83785(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|levels levels|compound|END_ENTITY	The effect of formoterol on peritoneal VEGF levels in rats with endometriosis .
24733958	0	formoterol	36,46	beta-2-adrenoreceptor	4,25	formoterol	beta-2-adrenoreceptor	MESH:C012629	154	Chemical	Gene	agonists|amod|START_ENTITY agonists|amod|END_ENTITY	The beta-2-adrenoreceptor agonists , formoterol and indacaterol , but not salbutamol , effectively suppress the reactivity of human neutrophils in vitro .
19899731	0	formoterol	83,93	beta2	56,61	formoterol	beta2	MESH:C012629	10242	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Reduction of stuttering through bronchodilatation with beta2 sympathomimetic drug formoterol -RSB- .
10492055	0	formoterol	30,40	beta2-adrenoceptor	70,88	formoterol	beta2-adrenoceptor	MESH:C012629	154	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Comparative trough effects of formoterol and salmeterol on lymphocyte beta2-adrenoceptor -- regulation and bronchodilatation .
11186251	0	formoterol	63,73	beta2-adrenoceptor	35,53	formoterol	beta2-adrenoceptor	MESH:C012629	24176(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Tocolytic effects of a long-acting beta2-adrenoceptor agonist , formoterol , in rats .
14678342	0	formoterol	121,131	beta2-adrenoceptor	16,34	formoterol	beta2-adrenoceptor	MESH:C012629	154	Chemical	Gene	treated|nmod|START_ENTITY patients|acl|treated bronchoprotective|nmod|patients predisposes|xcomp|bronchoprotective predisposes|nsubj|polymorphism polymorphism|amod|END_ENTITY	The arginine-16 beta2-adrenoceptor polymorphism predisposes to bronchoprotective subsensitivity in patients treated with formoterol and salmeterol .
15324892	0	formoterol	11,21	beta2-adrenoceptor	118,136	formoterol	beta2-adrenoceptor	MESH:C012629	154	Chemical	Gene	analogues|amod|START_ENTITY analogues|dep|investigation investigation|nmod|effect effect|acl|increasing increasing|nmod|activity activity|amod|END_ENTITY	Long-chain formoterol analogues : an investigation into the effect of increasing amino-substituent chain length on the beta2-adrenoceptor activity .
16432501	0	formoterol	56,66	beta2-adrenoceptor	27,45	formoterol	beta2-adrenoceptor	MESH:C012629	24176(Tax:10116)	Chemical	Gene	administration|amod|START_ENTITY administration|nmod|agonists agonists|amod|END_ENTITY	Systemic administration of beta2-adrenoceptor agonists , formoterol and salmeterol , elicit skeletal muscle_hypertrophy in rats at micromolar doses .
9440565	0	formoterol	130,140	beta2-adrenoceptor	77,95	formoterol	beta2-adrenoceptor	MESH:C012629	154	Chemical	Gene	induced|nmod|START_ENTITY subsensitivity|acl|induced subsensitivity|amod|END_ENTITY	Concomitant administration of low-dose prednisolone protects against in vivo beta2-adrenoceptor subsensitivity induced by regular formoterol .
1968754	0	formoterol	10,20	beta_2-adrenoceptor	37,56	formoterol	beta 2-adrenoceptor	MESH:C012629	154	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Effect of formoterol , a long-lasting beta_2-adrenoceptor agonist , against methacholine-induced bronchoconstriction .
7675115	0	formoterol	152,162	beta_2-adrenoceptor	124,143	formoterol	beta 2-adrenoceptor	MESH:C012629	100722663	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|administration administration|nmod|agonist agonist|amod|END_ENTITY	Beta-adrenoceptor regulation and functional responses in the guinea-pig following chronic administration of the long-acting beta_2-adrenoceptor agonist formoterol .
8746998	0	formoterol	46,56	beta_2-adrenoceptor	92,111	formoterol	beta 2-adrenoceptor	MESH:C012629	154	Chemical	Gene	START_ENTITY|nmod|agonists agonists|amod|END_ENTITY	Pharmacological basis for duration of effect : formoterol and salmeterol versus short-acting beta_2-adrenoceptor agonists .
20003162	0	formoterol	23,33	eotaxin-1	52,61	formoterol	eotaxin-1	MESH:C012629	6356	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Suppressive effects of formoterol and salmeterol on eotaxin-1 in bronchial epithelial cells .
22251095	0	formoterol	44,54	phosphoinositide-3-kinase	59,84	formoterol	phosphoinositide-3-kinase	MESH:C012629	5293	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|amod|END_ENTITY	Corticosteroid insensitivity is reversed by formoterol via phosphoinositide-3-kinase inhibition .
22293341	0	formyl	68,74	CXC_chemokine_receptor-4	39,63	formyl	CXC chemokine receptor-4	CHEBI:42485	7852	Chemical	Gene	receptor|amod|START_ENTITY END_ENTITY|nmod|receptor	b-amyloid42 induces desensitization of CXC_chemokine_receptor-4 via formyl peptide receptor in neural stem/progenitor cells .
16038804	0	formyl	54,60	ERK1/2	40,46	formyl	ERK1/2	CHEBI:42485	5595;5594	Chemical	Gene	receptor|amod|START_ENTITY END_ENTITY|nmod|receptor	Activation and nuclear translocation of ERK1/2 by the formyl peptide receptor is regulated by G protein and is not dependent on beta-arrestin translocation or receptor endocytosis .
22410002	0	formyl	76,82	FPR_1	102,107	formyl	FPR 1	CHEBI:42485	2357	Chemical	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	A non-peptide receptor inhibitor with selectivity for one of the neutrophil formyl peptide receptors , FPR_1 .
11212964	0	formyl-methionyl-leucyl-phenylalanine	96,133	Angiotensin_converting_enzyme	0,29	formyl-methionyl-leucyl-phenylalanine	Angiotensin converting enzyme	MESH:D009240	24310(Tax:10116)	Chemical	Gene	protects|nmod|START_ENTITY protects|nsubj|END_ENTITY	Angiotensin_converting_enzyme protects acetylcholine-induced relaxation from its attenuation by formyl-methionyl-leucyl-phenylalanine in rat aorta .
11509634	0	formyl-methionyl-leucyl-phenylalanine	71,108	IL-8	19,23	formyl-methionyl-leucyl-phenylalanine	IL-8	MESH:D009240	3576	Chemical	Gene	stimulated|nmod|START_ENTITY neutrophils|acl|stimulated induces|nmod|neutrophils induces|dobj|synthesis synthesis|compound|END_ENTITY	Fibrinogen induces IL-8 synthesis in human neutrophils stimulated with formyl-methionyl-leucyl-phenylalanine or leukotriene_B -LRB- 4 -RRB- .
1578146	1	formyl-methionyl-leucyl-phenylalanine	75,112	IL-8	156,160	formyl-methionyl-leucyl-phenylalanine	IL-8	MESH:D009240	3576	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	The chemoattractant formyl-methionyl-leucyl-phenylalanine induces the gene expression and release of IL-8 through a pertussis toxin-sensitive pathway .
8969228	0	formyl-methionyl-leucyl-phenylalanine	22,59	MEKK	14,18	formyl-methionyl-leucyl-phenylalanine	MEKK	MESH:D009240	4214	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of MEKK by formyl-methionyl-leucyl-phenylalanine in human neutrophils .
23506477	0	formylchromane	14,28	protein_tyrosine_phosphatase_1B	44,75	formylchromane	protein tyrosine phosphatase 1B	null	5770	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Validation of formylchromane derivatives as protein_tyrosine_phosphatase_1B inhibitors by pharmacophore modeling , atom-based 3D-QSAR and docking studies .
8147868	0	formylmethanofuran	32,50	dehydrogenase	51,64	formylmethanofuran	dehydrogenase	MESH:C050842	9704029	Chemical	Gene	synthesis|nmod|START_ENTITY END_ENTITY|nsubj|synthesis	Formylmethanofuran synthesis by formylmethanofuran dehydrogenase from Methanobacterium_thermoautotrophicum_Marburg .
17016779	0	forodesine	17,27	PNP	30,33	forodesine	PNP	MESH:C113101	4860	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Drug evaluation : forodesine - PNP inhibitor for the treatment of leukemia , lymphoma_and_solid_tumor .
3011721	0	forphenicinol	10,23	gamma-interferon	27,43	forphenicinol	gamma-interferon	null	15978(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Effect of forphenicinol on gamma-interferon production in mice sensitized with BCG .
11165046	0	forskolin	31,40	GH	0,2	forskolin	GH	MESH:D005576	2688	Chemical	Gene	elevated|nmod|START_ENTITY elevated|nsubj|levels levels|compound|END_ENTITY	GH mRNA levels are elevated by forskolin but not GH releasing hormone in GHRH_receptor-expressing MtT/S somatotroph cell line .
18028952	0	forskolin	59,68	Mitf	50,54	forskolin	Mitf	MESH:D005576	4286	Chemical	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of microphthalmia_transcription_factor -LRB- Mitf -RRB- by forskolin and stimulation of melanin release in UISO-Mel-6 cells .
2323384	0	forskolin	57,66	VIP	49,52	forskolin	VIP	MESH:D005576	117064(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- on forskolin stimulated adenylate cyclase in the caudate-putamen of the rat .
2482655	0	forskolin	108,117	VIP	59,62	forskolin	VIP	MESH:D005576	117064(Tax:10116)	Chemical	Gene	mimicked|nmod|START_ENTITY parotid|ccomp|mimicked parotid|nsubj|enhancement enhancement|nmod|secretion secretion|nmod|END_ENTITY	The enhancement of carbachol-induced salivary secretion by VIP and CGRP in rat parotid gland is mimicked by forskolin .
2429651	0	forskolin	80,89	atrial_natriuretic_peptide	26,52	forskolin	atrial natriuretic peptide	MESH:D005576	24602(Tax:10116)	Chemical	Gene	stimulated|nmod|START_ENTITY stimulated|nsubjpass|phorbol_ester phorbol_ester|acl|induced induced|dobj|secretion secretion|amod|END_ENTITY	The phorbol_ester induced atrial_natriuretic_peptide secretion is stimulated by forskolin and Bay_K8644 and inhibited by 8-bromo-cyclic_GMP .
2461711	0	forskolin	54,63	atrial_natriuretic_peptide	14,40	forskolin	atrial natriuretic peptide	MESH:D005576	24602(Tax:10116)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of atrial_natriuretic_peptide secretion by forskolin in noncontracting cultured atrial myocytes .
17484286	0	forskolin	10,19	claudin-5	41,50	forskolin	claudin-5	MESH:D005576	7122	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	Effect of forskolin on the expression of claudin-5 in human trophoblast BeWo cells .
21480364	0	forskolin	127,136	cyclin_D1	60,69	forskolin	cyclin D1	MESH:D005576	595	Chemical	Gene	induced|nmod|START_ENTITY differentiation|acl|induced contributes|nmod|differentiation contributes|nsubj|down-regulation down-regulation|nmod|END_ENTITY	Transcriptional and post-transcriptional down-regulation of cyclin_D1 contributes to C6 glioma cell differentiation induced by forskolin .
7681768	0	forskolin	38,47	growth_hormone	70,84	forskolin	growth hormone	MESH:D005576	81668(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|release release|amod|END_ENTITY	The effect of isobutylmethylxanthine , forskolin , and cholera toxin on growth_hormone release from pituitary cell cultures of perinatal and mature rats .
15036626	0	forskolin	91,100	inducible_nitric_oxide_synthase	27,58	forskolin	inducible nitric oxide synthase	MESH:D005576	4843	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Differential regulation of inducible_nitric_oxide_synthase and cytokine gene expression by forskolin and dibutyryl-cAMP in lipopolysaccharide-stimulated murine BV2 microglial cells .
16239525	0	forskolin	11,20	interleukin-10	51,65	forskolin	interleukin-10	MESH:D005576	25325(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	Effects of forskolin on Kupffer cell production of interleukin-10 and tumor_necrosis_factor_alpha differ from those of endogenous adenylyl cyclase activators : possible role for adenylyl cyclase 9 .
18028952	0	forskolin	59,68	microphthalmia_transcription_factor	13,48	forskolin	microphthalmia transcription factor	MESH:D005576	4286	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of microphthalmia_transcription_factor -LRB- Mitf -RRB- by forskolin and stimulation of melanin release in UISO-Mel-6 cells .
15459237	0	forskolin	32,41	pregnane_X_receptor	59,78	forskolin	pregnane X receptor	MESH:D005576	8856	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|dep|role role|nmod|END_ENTITY	Induction of drug metabolism by forskolin : the role of the pregnane_X_receptor and the protein kinase a signal transduction pathway .
1571831	0	forskolin	59,68	tissue_plasminogen_activator	72,100	forskolin	tissue plasminogen activator	MESH:D005576	100128998	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Effects of interleukin-1 , _ tumor_necrosis_factor _ - beta , and forskolin on tissue_plasminogen_activator activity in human osteoblastic_osteosarcoma cells .
1686787	0	forskolin	84,93	tyrosine_hydroxylase	13,33	forskolin	tyrosine hydroxylase	MESH:D005576	25085(Tax:10116)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of tyrosine_hydroxylase in the rat substantia nigra by local injection of forskolin .
2323384	0	forskolin	57,66	vasoactive_intestinal_polypeptide	14,47	forskolin	vasoactive intestinal polypeptide	MESH:D005576	117064(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- on forskolin stimulated adenylate cyclase in the caudate-putamen of the rat .
22848794	4	forskolin-stimulated_cyclic_adenosine_monophosphate	686,737	cAMP	739,743	forskolin-stimulated cyclic adenosine monophosphate	NPFF	null	54615(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY production|appos|END_ENTITY	The KSO peptide inhibited forskolin-stimulated_cyclic_adenosine_monophosphate -LRB- cAMP -RRB- production in ND7/23 neuroblastoma cells via an action that could be inhibited by the NPFF receptor antagonist RF9 .
2970855	0	fosenopril	11,21	angiotensin-converting_enzyme	36,65	fosenopril	angiotensin-converting enzyme	MESH:D017328	1636	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effects of fosenopril , a once-daily angiotensin-converting_enzyme inhibitor , on resting and exercise-induced changes of blood pressure , hormonal variables , and plasma potassium in essential hypertension .
2880486	0	fosfomycin	86,96	NAG	9,12	fosfomycin	NAG	MESH:D005578	10724	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|dep|effect	-LSB- Urinary NAG and gamma-GTP activities as indicators of CDDP_renal_toxicity : effect of fosfomycin on CDDP_renal_toxicity -RSB- .
17194386	0	fosfomycin	13,23	beta-lactamase	50,64	fosfomycin	beta-lactamase	MESH:D005578	7872529(Tax:562)	Chemical	Gene	Activity|nmod|START_ENTITY END_ENTITY|nsubj|Activity	-LSB- Activity of fosfomycin against extended-spectrum beta-lactamase producing Escherichia_coli and Klebsiella_pneumoniae -RSB- .
11329095	0	fosinopril	57,67	ACE	37,40	fosinopril	ACE	MESH:D017328	1636	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|effects effects|nmod|END_ENTITY	The hemodynamic effects of long-term ACE inhibition with fosinopril in patients with heart_failure .
15938534	0	fosinopril	26,36	ACE	12,15	fosinopril	ACE	MESH:D017328	1636	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|Effects Effects|nmod|END_ENTITY	-LSB- Effects of ACE inhibitor fosinopril on a 24-h profile of arterial pressure in hypertensive patients with obesity and hypercholesterolemia -RSB- .
9015418	0	fosinopril	76,86	ACE	61,64	fosinopril	ACE	MESH:D017328	1636	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Plasma endothelin in congestive heart_failure : effect of the ACE inhibitor , fosinopril .
12877808	0	fosinopril	11,21	ICAM-1	54,60	fosinopril	ICAM-1	MESH:D017328	3383	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expressions expressions|nmod|END_ENTITY	Effects of fosinopril and valsartan on expressions of ICAM-1 and NO in human umbilical vein endothelial cells .
21311136	0	fosinopril	11,21	Klotho	44,50	fosinopril	Klotho	MESH:D017328	83504(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of fosinopril and losartan on renal Klotho expression and oxidative stress in spontaneously hypertensive rats .
15755760	0	fosinopril	112,122	STAT3	29,34	fosinopril	STAT3	MESH:D017328	25125(Tax:10116)	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression and activation of STAT3 in chronic proliferative immune complex glomerulonephritis and the effect of fosinopril .
7957538	0	fosinopril	77,87	angiotensin-converting_enzyme	145,174	fosinopril	angiotensin-converting enzyme	MESH:D017328	1636	Chemical	Gene	inhibition|nmod|START_ENTITY effects|nmod|inhibition effects|dep|relationship relationship|nmod|inhibition inhibition|amod|END_ENTITY	Metabolic effects of long-term angiotensin-converting_enzyme inhibition with fosinopril in patients with essential hypertension : relationship to angiotensin-converting_enzyme inhibition .
7957538	0	fosinopril	77,87	angiotensin-converting_enzyme	31,60	fosinopril	angiotensin-converting enzyme	MESH:D017328	1636	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Metabolic effects of long-term angiotensin-converting_enzyme inhibition with fosinopril in patients with essential hypertension : relationship to angiotensin-converting_enzyme inhibition .
9186076	0	fosinopril	177,187	angiotensin-converting_enzyme	83,112	fosinopril	angiotensin-converting enzyme	MESH:D017328	1636	Chemical	Gene	comparison|nmod|START_ENTITY differences|dep|comparison differences|nmod|response response|nmod|pressure pressure|acl|lowering lowering|nmod|inhibition inhibition|amod|END_ENTITY	Racial differences in the renal response to blood pressure lowering during chronic angiotensin-converting_enzyme inhibition : a prospective double-blind randomized comparison of fosinopril and lisinopril in older hypertensive patients with chronic_renal_insufficiency .
7986469	0	fosinopril	114,124	angiotensin_converting_enzyme	68,97	fosinopril	angiotensin converting enzyme	MESH:D017328	1636	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Unchanged neurogenic vasoconstrictor response after exercise during angiotensin_converting_enzyme inhibition with fosinopril .
8934359	0	fosinopril	45,55	angiotensin_converting_enzyme	4,33	fosinopril	angiotensin converting enzyme	MESH:D017328	1636	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	The angiotensin_converting_enzyme inhibitors fosinopril and enalapril differ in their central nervous effects in humans .
26617877	0	fosinopril	10,20	chemerin	24,32	fosinopril	chemerin	MESH:D017328	297073(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of fosinopril on chemerin and VEGF expression in diabetic_nephropathy rats .
8281674	0	fosinopril_sodium	46,63	Angiotensin-converting_enzyme	0,29	fosinopril sodium	Angiotensin-converting enzyme	MESH:D017328	1636	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Angiotensin-converting_enzyme inhibition with fosinopril_sodium in the prevention of restenosis after coronary angioplasty .
7658352	0	fosinopril_sodium	24,41	angiotensin-converting_enzyme	49,78	fosinopril sodium	angiotensin-converting enzyme	MESH:D017328	1636	Chemical	Gene	behavior|nmod|START_ENTITY behavior|dep|inhibitor inhibitor|amod|END_ENTITY	Aggregation behavior of fosinopril_sodium -- a new angiotensin-converting_enzyme inhibitor .
23190017	0	fostamatinib	20,32	SYK	60,63	fostamatinib	SYK	MESH:C523665	6850	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|appos|END_ENTITY	Pharmacokinetics of fostamatinib , a spleen tyrosine kinase -LRB- SYK -RRB- inhibitor , in healthy human subjects following single and multiple oral dosing in three phase I studies .
22284392	0	fostamatinib	20,32	Syk	0,3	fostamatinib	Syk	MESH:C523665	6850	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Syk inhibition with fostamatinib leads to transitional B lymphocyte depletion .
26148346	0	fostamatinib	39,51	Syk	24,27	fostamatinib	Syk	MESH:C523665	20963(Tax:10090)	Chemical	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	Spleen tyrosine kinase -LRB- Syk -RRB- inhibitor fostamatinib limits tissue_damage and fibrosis in a bleomycin-induced scleroderma_mouse model .
8965249	0	fotemustine	55,66	Cytochrome-P450	0,15	fotemustine	Cytochrome-P450	MESH:C054368	13079(Tax:10090)	Chemical	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Cytochrome-P450 induction and antineoplastic action of fotemustine in mice .
15789339	0	fractalkine	36,47	CX3CL1	29,35	fractalkine	CX3CL1	MESH:D054428	20312(Tax:10090)	Chemical	Gene	transfer|amod|START_ENTITY transfer|compound|END_ENTITY	Antitumor immune response by CX3CL1 fractalkine gene transfer depends on both NK and T cells .
15880599	0	fractalkine	14,25	CX3CL1	27,33	fractalkine	CX3CL1	MESH:D054428	20312(Tax:10090)	Chemical	Gene	delays|amod|START_ENTITY delays|appos|END_ENTITY	Antagonist of fractalkine -LRB- CX3CL1 -RRB- delays the initiation and ameliorates the progression of lupus_nephritis in MRL/lpr mice .
21463954	0	fractalkine	12,23	CX3CL1	25,31	fractalkine	CX3CL1	MESH:D054428	6376	Chemical	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	High plasma fractalkine -LRB- CX3CL1 -RRB- levels are associated with severe liver_disease in HIV/HCV _ co-infected patients with HCV genotype 1 .
24851083	0	fractalkine	40,51	CX3CL1	32,38	fractalkine	CX3CL1	MESH:D054428	6376	Chemical	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	Chorioamnionitis -LRB- ChA -RRB- modifies CX3CL1 -LRB- fractalkine -RRB- production by human amniotic epithelial cells -LRB- HAEC -RRB- under normoxic and hypoxic conditions .
12059974	0	fractalkine	14,25	CX3CR1	44,50	fractalkine	CX3CR1	MESH:D054428	171056(Tax:10116)	Chemical	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of fractalkine and its receptor , CX3CR1 , in response to ischaemia-reperfusion brain_injury in the rat .
11282163	0	fractalkine	43,54	TNFalpha	77,85	fractalkine	TNFalpha	MESH:D054428	24835(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	In vivo neutralization of endogenous brain fractalkine increases hippocampal TNFalpha and 8-isoprostane production induced by intracerebroventricular injection of LPS .
9883886	0	fractalkine	60,71	US28	134,138	fractalkine	US28	MESH:D054428	3077536(Tax:10359)	Chemical	Gene	recognition|amod|START_ENTITY recognition|nmod|END_ENTITY	Selective recognition of the membrane-bound CX3C chemokine , fractalkine , by the human_cytomegalovirus-encoded broad-spectrum receptor US28 .
26699911	0	free_fatty_acid	9,24	GPR40	0,5	free fatty acid	GPR40	null	233081(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY END_ENTITY|appos|receptor	GPR40 , a free_fatty_acid receptor , differentially impacts osteoblast behavior depending on differentiation stage and environment .
4348588	0	free_fatty_acids	35,51	angiotensin_II	10,24	free fatty acids	angiotensin II	MESH:D005230	183	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of angiotensin_II on plasma free_fatty_acids in hypertensive subjects with and without overweight .
2764485	0	fructosamine	15,27	albumin	41,48	fructosamine	albumin	MESH:D019270	213	Chemical	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	Alterations in fructosamine and glycated albumin levels during childhood .
2187348	0	fructosamine	6,18	insulin	38,45	fructosamine	insulin	MESH:D019270	3630	Chemical	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	Serum fructosamine and amniotic fluid insulin levels in patients with gestational_diabetes and healthy control subjects .
10465505	0	fructose	16,24	GLP-1	47,52	fructose	GLP-1	MESH:D005632	2641	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of oral fructose and glucose on plasma GLP-1 and appetite in normal subjects .
10926838	0	fructose	15,23	GLUT2	100,105	fructose	GLUT2	MESH:D005632	25351(Tax:10116)	Chemical	Gene	transport|amod|START_ENTITY Stimulation|nmod|transport mediated|nsubjpass|Stimulation mediated|nmod|END_ENTITY	Stimulation of fructose transport across the intestinal brush-border membrane by PMA is mediated by GLUT2 and dynamically regulated by protein_kinase_C .
10926840	0	fructose	55,63	GLUT2	21,26	fructose	GLUT2	MESH:D005632	25351(Tax:10116)	Chemical	Gene	absorption|compound|START_ENTITY absorption|compound|END_ENTITY	Regulation of GLUT5 , GLUT2 and intestinal brush-border fructose absorption by the extracellular_signal-regulated_kinase , p38 mitogen-activated kinase and phosphatidylinositol 3-kinase intracellular signalling pathways : implications for adaptation to diabetes .
8405848	0	fructose	29,37	GLUT2	0,5	fructose	GLUT2	MESH:D005632	25351(Tax:10116)	Chemical	Gene	membrane|amod|START_ENTITY transporter|nmod|membrane transporter|nsubj|END_ENTITY	GLUT2 is the transporter for fructose across the rat intestinal basolateral membrane .
8832792	0	fructose	31,39	GLUT2	53,58	fructose	GLUT2	MESH:D005632	6514	Chemical	Gene	regulation|nmod|START_ENTITY transporters|nsubj|regulation transporters|dobj|END_ENTITY	Differential regulation of the fructose transporters GLUT2 and GLUT5 in the intestinal cell line Caco-2 .
10926840	0	fructose	55,63	GLUT5	14,19	fructose	GLUT5	MESH:D005632	65197(Tax:10116)	Chemical	Gene	absorption|compound|START_ENTITY absorption|compound|GLUT2 GLUT2|compound|END_ENTITY	Regulation of GLUT5 , GLUT2 and intestinal brush-border fructose absorption by the extracellular_signal-regulated_kinase , p38 mitogen-activated kinase and phosphatidylinositol 3-kinase intracellular signalling pathways : implications for adaptation to diabetes .
10976531	0	fructose	28,36	GLUT5	91,96	fructose	GLUT5	MESH:D005632	6518	Chemical	Gene	Synthesis|nmod|START_ENTITY analogues|nsubj|Synthesis analogues|nmod|inhibitors inhibitors|nmod|END_ENTITY	Synthesis and evaluation of fructose analogues as inhibitors of the D-fructose transporter GLUT5 .
11716754	11	fructose	1797,1805	GLUT5	1645,1650	fructose	GLUT5	MESH:D005632	6518	Chemical	Gene	transport|amod|START_ENTITY increases|nmod|transport leading|nmod|increases lining|dep|leading cells|dep|lining involve|nmod|cells seems|xcomp|involve seems|nsubj|regulation regulation|nummod|END_ENTITY	In contrast , GLUT5 regulation by the diet seems to involve de novo synthesis of GLUT5 mRNA synthesis and protein in cells lining the villus , leading to increases in fructose transport a few hours after consumption of diets containing fructose .
11716754	11	fructose	1866,1874	GLUT5	1645,1650	fructose	GLUT5	MESH:D005632	6518	Chemical	Gene	containing|dobj|START_ENTITY diets|acl|containing consumption|nmod|diets hours|nmod|consumption lining|dobj|hours cells|dep|lining involve|nmod|cells seems|xcomp|involve seems|nsubj|regulation regulation|nummod|END_ENTITY	In contrast , GLUT5 regulation by the diet seems to involve de novo synthesis of GLUT5 mRNA synthesis and protein in cells lining the villus , leading to increases in fructose transport a few hours after consumption of diets containing fructose .
15542355	0	fructose	37,45	GLUT5	106,111	fructose	GLUT5	MESH:D005632	65197(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY changes|nmod|uptake explained|nsubjpass|changes explained|nmod|alterations alterations|nmod|abundance abundance|nmod|END_ENTITY	Age-associated changes in intestinal fructose uptake are not explained by alterations in the abundance of GLUT5 or GLUT2 .
24918004	0	fructose	72,80	GLUT5	22,27	fructose	GLUT5	MESH:D005632	6518	Chemical	Gene	intolerance|amod|START_ENTITY patients|nmod|intolerance transporters|nmod|patients transporters|dobj|expression expression|compound|END_ENTITY	Fructose transporters GLUT5 and GLUT2 expression in adult patients with fructose intolerance .
26375593	0	fructose	28,36	GLUT5	99,104	fructose	GLUT5	MESH:D005632	6518	Chemical	Gene	analogs|amod|START_ENTITY fluorinated|dobj|analogs fluorinated|nmod|probes probes|nmod|END_ENTITY	Correction : New fluorinated fructose analogs as selective probes of the hexose transporter protein GLUT5 .
7588216	0	fructose	114,122	GLUT5	108,113	fructose	GLUT5	MESH:D005632	65197(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Characterization of rat GLUT5 and functional analysis of chimeric proteins of GLUT1 glucose transporter and GLUT5 fructose transporter .
8037665	0	fructose	38,46	GLUT5	60,65	fructose	GLUT5	MESH:D005632	6518	Chemical	Gene	transporter|compound|START_ENTITY expression|nmod|transporter Regulation|nmod|expression Regulation|appos|END_ENTITY	Regulation of expression of the human fructose transporter -LRB- GLUT5 -RRB- by cyclic_AMP .
8662294	0	fructose	88,96	GLUT5	18,23	fructose	GLUT5	MESH:D005632	65197(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY adaptation|nmod|transport regulation|nmod|adaptation regulation|nmod|activity activity|compound|END_ENTITY	The regulation of GLUT5 and GLUT2 activity in the adaptation of intestinal brush-border fructose transport in diabetes .
8941659	0	fructose	26,34	GLUT5	53,58	fructose	GLUT5	MESH:D005632	6518	Chemical	Gene	gene|amod|START_ENTITY analysis|nmod|gene analysis|appos|END_ENTITY	Molecular analysis of the fructose transporter gene -LRB- GLUT5 -RRB- in isolated_fructose_malabsorption .
9820812	0	fructose	57,65	GLUT5	51,56	fructose	GLUT5	MESH:D005632	65197(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|characterization characterization|nmod|END_ENTITY	Biochemical and functional characterization of the GLUT5 fructose transporter in rat skeletal muscle .
22822162	0	fructose	51,59	Glucose_transporter_8	0,21	fructose	Glucose transporter 8	MESH:D005632	154091	Chemical	Gene	transport|compound|START_ENTITY regulates|dobj|transport regulates|nsubj|END_ENTITY	Glucose_transporter_8 -LRB- GLUT8 -RRB- regulates enterocyte fructose transport and global mammalian fructose utilization .
19091748	0	fructose	50,58	Glut5	8,13	fructose	Glut5	MESH:D005632	56485(Tax:10090)	Chemical	Gene	absorption|nmod|START_ENTITY essential|nmod|absorption essential|nsubj|Slc2a5 Slc2a5|appos|END_ENTITY	Slc2a5 -LRB- Glut5 -RRB- is essential for the absorption of fructose in the intestine and generation of fructose-induced hypertension .
13959930	0	fructose	20,28	Insulin	0,7	fructose	Insulin	MESH:D005632	3630	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Insulin response to fructose and galactose .
13991334	0	fructose	20,28	Insulin	0,7	fructose	Insulin	MESH:D005632	3630	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Insulin response to fructose and galactose .
5800368	0	fructose	46,54	Insulin	0,7	fructose	Insulin	MESH:D005632	3630	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Insulin and corticoid response to intravenous fructose in relation to glucose tolerance .
5842826	0	fructose	76,84	Insulin	0,7	fructose	Insulin	MESH:D005632	3630	Chemical	Gene	metabolism|compound|START_ENTITY lipolysis|nmod|metabolism lipolysis|nsubj|inhibition inhibition|compound|END_ENTITY	Insulin inhibition of spontaneous adipose tissue lipolysis and effects upon fructose and glucose metabolism .
6280778	0	fructose	43,51	Insulin	0,7	fructose	Insulin	MESH:D005632	100009181(Tax:9986)	Chemical	Gene	effects|nmod|START_ENTITY effects|compound|END_ENTITY	Insulin and dexamethasone effects on liver fructose bisphosphatase .
18487473	0	fructose	41,49	SLC2A9	62,68	fructose	SLC2A9	MESH:D005632	56606	Chemical	Gene	variants|amod|START_ENTITY variants|compound|END_ENTITY	Sex-specific association of the putative fructose transporter SLC2A9 variants with uric_acid levels is modified by BMI .
24434080	0	fructose	7,15	Sirt1	30,35	fructose	Sirt1	MESH:D005632	309757(Tax:10116)	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	Liquid fructose downregulates Sirt1 expression and activity and impairs the oxidation of fatty_acids in rat and human liver cells .
11076949	0	fructose	106,114	glucokinase	49,60	fructose	glucokinase	MESH:D005632	2645	Chemical	Gene	phosphorylation|amod|START_ENTITY END_ENTITY|nmod|phosphorylation	Analysis of the cooperativity of human beta-cell glucokinase through the stimulatory effect of glucose on fructose phosphorylation .
1127073	0	fructose	36,44	insulin	4,11	fructose	insulin	MESH:D005632	3630	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	The insulin response to intravenous fructose in relation to blood glucose levels .
156932	0	fructose	145,153	insulin	7,14	fructose	insulin	MESH:D005632	3630	Chemical	Gene	and_galactose|amod|START_ENTITY _|xcomp|and_galactose _|nsubj|END_ENTITY	Plasma insulin , carbohydrate , and free fatty_acid changes in newly born infants of diabetic and non-diabetic mothers after loading with glucose , _ fructose , _ and_galactose .
19208729	0	fructose	45,53	insulin	135,142	fructose	insulin	MESH:D005632	3630	Chemical	Gene	beverages|amod|START_ENTITY consuming|dobj|beverages effects|acl|consuming effects|dep|influence influence|nmod|resistance resistance|compound|END_ENTITY	Endocrine and metabolic effects of consuming fructose - and glucose-sweetened beverages with meals in obese men and women : influence of insulin resistance on plasma triglyceride responses .
2232095	0	fructose	13,21	insulin	39,46	fructose	insulin	MESH:D005632	3630	Chemical	Gene	metabolism|amod|START_ENTITY END_ENTITY|dep|metabolism	Is exogenous fructose metabolism truly insulin independent ?
25645909	0	fructose	51,59	insulin	104,111	fructose	insulin	MESH:D005632	3630	Chemical	Gene	suppression|acl|START_ENTITY suppression|dep|role role|nmod|resistance resistance|compound|END_ENTITY	Blunted suppression of acyl-ghrelin in response to fructose ingestion in obese adolescents : The role of insulin resistance .
2683715	0	fructose	133,141	insulin	18,25	fructose	insulin	MESH:D005632	3630	Chemical	Gene	cornstarch|amod|START_ENTITY containing|dobj|cornstarch diets|acl|containing adapted|nmod|diets men|acl|adapted END_ENTITY|appos|men	Day-long_glucose , _ insulin , _ and_fructose_responses_of_hyperinsulinemic_and_nonhyperinsulinemic men adapted to diets containing either fructose or high-amylose cornstarch .
6350543	0	fructose	24,32	insulin	6,13	fructose	insulin	MESH:D005632	3630	Chemical	Gene	levels|compound|START_ENTITY END_ENTITY|appos|levels	Blood insulin , glucose , fructose and gastric inhibitory polypeptide levels in carbohydrate-sensitive and normal men given a sucrose or invert sugar tolerance test .
7002688	0	fructose	36,44	insulin	4,11	fructose	insulin	MESH:D005632	3630	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	The insulin response to intravenous fructose in maturity-onset_diabetes_mellitus and in normal subjects .
7351877	0	fructose	23,31	insulin	84,91	fructose	insulin	MESH:D005632	3630	Chemical	Gene	sorbitol|dep|START_ENTITY Comparison|nmod|sorbitol Comparison|nmod|humans humans|nmod|suppression suppression|compound|END_ENTITY	Comparison of glucose , fructose , sorbitol , and xylitol utilization in humans during insulin suppression .
736715	0	fructose	206,214	insulin	60,67	fructose	insulin	MESH:D005632	280829(Tax:9913)	Chemical	Gene	galactose|amod|START_ENTITY _|dobj|galactose _|nsubj|Behavior Behavior|nmod|constituents constituents|dep|fatty_acids fatty_acids|dep|END_ENTITY	-LSB- Behavior of various blood constituents -LRB- glucose , fructose , insulin , lactate , pyruvate , free fatty_acids , inorganic phosphate -RRB- and half-life of monosaccharides in the plasma after i.v. infusion of glucose , _ fructose , _ galactose and invert sugar solutions in ruminants .
736715	0	fructose	50,58	insulin	60,67	fructose	insulin	MESH:D005632	280829(Tax:9913)	Chemical	Gene	fatty_acids|dep|START_ENTITY fatty_acids|dep|END_ENTITY	-LSB- Behavior of various blood constituents -LRB- glucose , fructose , insulin , lactate , pyruvate , free fatty_acids , inorganic phosphate -RRB- and half-life of monosaccharides in the plasma after i.v. infusion of glucose , _ fructose , _ galactose and invert sugar solutions in ruminants .
736716	0	fructose	50,58	insulin	60,67	fructose	insulin	MESH:D005632	280829(Tax:9913)	Chemical	Gene	fatty_acids|dep|START_ENTITY fatty_acids|dep|END_ENTITY	-LSB- Behavior of various blood constituents -LRB- glucose , fructose , insulin , lactate , pyruvate , free fatty_acids , inorganic phosphate -RRB- and half-life of monosaccharides in the plasma after i.v. infusion of glucose , fructose , galactose and invert sugar solutions in ruminants .
736717	0	fructose	50,58	insulin	60,67	fructose	insulin	MESH:D005632	105613195	Chemical	Gene	fatty_acids|dep|START_ENTITY fatty_acids|dep|END_ENTITY	-LSB- Behavior of various blood constituents -LRB- glucose , fructose , insulin , lactate , pyruvate , free fatty_acids , inorganic phosphate -RRB- and the half-life of monosaccharides in plasma after i.v infusion of glucose , fructose , galactose and invert sugar solutions in ruminants .
9538964	0	fructose	36,44	insulin	15,22	fructose	insulin	MESH:D005632	3630	Chemical	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Stimulation of insulin secretion by fructose ingested with protein in people with untreated type 2 diabetes .
24445051	0	fructose	7,15	insulin_receptor_substrate_2	37,65	fructose	insulin receptor substrate 2	MESH:D005632	29376(Tax:10116)	Chemical	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|END_ENTITY	Liquid fructose down-regulates liver insulin_receptor_substrate_2 and gluconeogenic enzymes by modifying nutrient sensing factors in rats .
8015342	0	fructose	43,51	oxytocin	10,18	fructose	oxytocin	MESH:D005632	18429(Tax:10090)	Chemical	Gene	concentration|nmod|START_ENTITY Effect|nmod|concentration Effect|nmod|END_ENTITY	Effect of oxytocin on the concentration of fructose in the accessory glands of mouse .
12832054	0	fructose	16,24	rNaGLT1	39,46	fructose	rNaGLT1	MESH:D005632	337920(Tax:10116)	Chemical	Gene	transport|amod|START_ENTITY transport|nmod|END_ENTITY	Na -LRB- + -RRB- - dependent fructose transport via rNaGLT1 in rat kidney .
3942758	0	fructose-bisphosphate	53,74	aldolase	75,83	fructose-bisphosphate	aldolase	null	542930(Tax:4565)	Chemical	Gene	subunits|amod|START_ENTITY subunits|compound|END_ENTITY	Specific , limited tryptic modification of wheat-germ fructose-bisphosphate aldolase subunits : destruction of catalytic activity but not of ability to establish precise subunit-subunit recognition .
25482937	0	fruquintinib	13,25	VEGFR_1	85,92	fruquintinib	VEGFR 1	MESH:C000591844	14254(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Discovery of fruquintinib , a potent and highly selective small molecule inhibitor of VEGFR_1 , 2 , 3 tyrosine kinases for cancer therapy .
10510146	0	frusemide	63,72	renin	45,50	frusemide	renin	MESH:D005665	5972	Chemical	Gene	response|acl|START_ENTITY response|amod|END_ENTITY	The effect of nitric_oxide inhibition on the renin response to frusemide , in man .
1071582	0	frusemide	34,43	renin	15,20	frusemide	renin	MESH:D005665	24715(Tax:10116)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Stimulation Stimulation|nmod|END_ENTITY	Stimulation of renin secretion by frusemide and diazoxide in the isolated rat kidney .
1192694	0	frusemide	22,31	renin	42,47	frusemide	renin	MESH:D005665	5972	Chemical	Gene	START_ENTITY|nmod|concentration concentration|compound|END_ENTITY	Effect of intravenous frusemide on plasma renin concentration : suppression of response in hypertension .
1204285	0	frusemide	33,42	renin	92,97	frusemide	renin	MESH:D005665	5972	Chemical	Gene	effects|nmod|START_ENTITY venous|nsubj|effects venous|dobj|activity activity|compound|END_ENTITY	The early effects of intravenous frusemide on central haemodynamics , venous tone and plasma renin activity .
3328781	0	frusemide	15,24	renin	68,73	frusemide	renin	MESH:D005665	443310(Tax:9940)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activity activity|compound|END_ENTITY	The effects of frusemide , saralasin and hypotension on fetal plasma renin activity and on fetal renal function .
6992177	0	frusemide	11,20	renin	49,54	frusemide	renin	MESH:D005665	443310(Tax:9940)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|concentrations concentrations|nmod|END_ENTITY	Effects of frusemide on plasma concentrations of renin and prostaglandins_E_and_A in fetal sheep .
6996661	0	frusemide	47,56	renin	29,34	frusemide	renin	MESH:D005665	5972	Chemical	Gene	Effect|acl|START_ENTITY Effect|nmod|propranolol propranolol|nmod|response response|compound|END_ENTITY	Effect of propranolol on the renin response to frusemide in man .
6996879	0	frusemide	12,21	renin	62,67	frusemide	renin	MESH:D005665	5972	Chemical	Gene	Response|acl|START_ENTITY Response|dep|dissociation dissociation|nmod|responses responses|amod|END_ENTITY	Response to frusemide in acute_renal_failure : dissociation of renin and diuretic responses .
7018795	0	frusemide	43,52	renin	9,14	frusemide	renin	MESH:D005665	100358545(Tax:9986)	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|dep|effect	Inactive renin in rabbit plasma : effect of frusemide .
7543396	0	frusemide	80,89	renin	52,57	frusemide	renin	MESH:D005665	100358545(Tax:9986)	Chemical	Gene	Effect|acl|START_ENTITY Effect|nmod|blockade blockade|nmod|synthesis synthesis|nmod|response response|compound|END_ENTITY	Effect of blockade of nitric_oxide synthesis on the renin secretory response to frusemide in conscious rabbits .
884392	0	frusemide	45,54	renin	26,31	frusemide	renin	MESH:D005665	24715(Tax:10116)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|stimulation stimulation|nmod|END_ENTITY	Intrarenal stimulation of renin secretion by frusemide in the isolated kidney of the rat .
1926066	0	fucan_sulfate	27,40	Antithrombin	0,12	fucan sulfate	Antithrombin	MESH:C007789	462	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Antithrombin activity of a fucan_sulfate from the brown_seaweed_Ecklonia_kurome .
19302807	0	fucoidan	20,28	lipoprotein_lipase	32,50	fucoidan	lipoprotein lipase	MESH:C007789	4023	Chemical	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	Increased effect of fucoidan on lipoprotein_lipase secretion in adipocytes .
17038352	0	fucose	108,114	LFA-3	99,104	fucose	LFA-3	MESH:D005643	965	Chemical	Gene	removal|amod|START_ENTITY END_ENTITY|nmod|removal	Enhanced Fc-dependent cellular cytotoxicity of Fc fusion proteins derived from TNF receptor II and LFA-3 by fucose removal from Asn-linked oligosaccharides .
3653406	0	fucose	27,33	transferrin	41,52	fucose	transferrin	MESH:D005643	24825(Tax:10116)	Chemical	Gene	stability|nmod|START_ENTITY stability|nmod|END_ENTITY	Metabolic stability of the fucose in rat transferrin .
2245414	0	fucoxanthin	22,33	N-myc	60,65	fucoxanthin	N-myc	MESH:C025164	4613	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|compound|END_ENTITY	Inhibitory effects of fucoxanthin , a natural carotenoid , on N-myc expression and cell cycle progression in human malignant_tumor cells .
23516000	0	fucoxanthin	67,78	stearoyl-CoA_desaturase-1	27,52	fucoxanthin	stearoyl-CoA desaturase-1	MESH:C025164	20249(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Down-regulation of hepatic stearoyl-CoA_desaturase-1 expression by fucoxanthin via leptin signaling in diabetic/obese KK-A -LRB- y -RRB- mice .
18579549	0	fudosteine	10,20	mucin	24,29	fudosteine	mucin	MESH:C113797	100508689	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|production production|compound|END_ENTITY	Effect of fudosteine on mucin production .
15246359	0	fulvestrant	118,129	estrogen_receptor	10,27	fulvestrant	estrogen receptor	MESH:C070081	2099	Chemical	Gene	16alpha-position|nmod|START_ENTITY substitution|nmod|16alpha-position uptake|nmod|substitution binding|dobj|uptake binding|nsubj|Impact Impact|nmod|END_ENTITY	Impact on estrogen_receptor binding and target tissue uptake of -LSB- 18F -RSB- fluorine substitution at the 16alpha-position of fulvestrant -LRB- faslodex ; ICI_182 ,780 -RRB- .
19675520	0	fulvestrant	11,22	estrogen_receptor	27,44	fulvestrant	estrogen receptor	MESH:C070081	2099	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Effects of fulvestrant , an estrogen_receptor antagonist , on MMQ cells and its mechanism .
21292820	0	fulvestrant	36,47	estrogen_receptor	85,102	fulvestrant	estrogen receptor	MESH:C070081	2099	Chemical	Gene	efficacy|nmod|START_ENTITY enhances|dobj|efficacy enhances|advcl|amplifying amplifying|dobj|aggregation aggregation|nmod|END_ENTITY	Bortezomib enhances the efficacy of fulvestrant by amplifying the aggregation of the estrogen_receptor , which leads to a proapoptotic unfolded protein response .
25534230	0	fulvestrant	23,34	estrogen_receptor	38,55	fulvestrant	estrogen receptor	MESH:C070081	2099	Chemical	Gene	efficacy|nmod|START_ENTITY efficacy|nmod|gastric_cancer gastric_cancer|amod|END_ENTITY	Anti-tumor efficacy of fulvestrant in estrogen_receptor positive gastric_cancer .
9177176	0	fumagillin	26,36	methionine_aminopeptidase	71,96	fumagillin	methionine aminopeptidase	MESH:C026211	852187(Tax:4932)	Chemical	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine_aminopeptidase , MetAP-2 .
19929003	0	fumagillin	23,33	methionine_aminopeptidase-2	68,95	fumagillin	methionine aminopeptidase-2	MESH:C026211	10988	Chemical	Gene	analogues|nmod|START_ENTITY analogues|nmod|END_ENTITY	Carbamate analogues of fumagillin as potent , targeted inhibitors of methionine_aminopeptidase-2 .
22509410	0	fumagillin	21,31	methionine_aminopeptidase-2	49,76	fumagillin	methionine aminopeptidase-2	MESH:C026211	64370(Tax:10116)	Chemical	Gene	treatment|nmod|START_ENTITY treatment|appos|inhibitor inhibitor|nmod|END_ENTITY	Early treatment with fumagillin , an inhibitor of methionine_aminopeptidase-2 , prevents Pulmonary_Hypertension in monocrotaline-injured rats .
7622334	0	fumarate	74,82	SDH	127,130	fumarate	SDH	CHEBI:29806	6390	Chemical	Gene	reductase|amod|START_ENTITY reductase|appos|END_ENTITY	The effect of electron transport -LRB- ET -RRB- inhibitors and thiabendazole on the fumarate reductase -LRB- FR -RRB- and succinate_dehydrogenase -LRB- SDH -RRB- of Strongyloides ratti infective -LRB- L3 -RRB- larvae .
16574297	0	fumonisin	126,135	peroxisome_proliferator-activated_receptor_alpha	48,96	fumonisin	peroxisome proliferator-activated receptor alpha	CHEBI:38224	19013(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY modulating|dobj|effects END_ENTITY|acl|modulating	The role of tumor_necrosis_factor_alpha and the peroxisome_proliferator-activated_receptor_alpha in modulating the effects of fumonisin in mouse liver .
10212208	0	fumonisin_B1	14,26	p21	59,62	fumonisin B1	p21	MESH:C056933	1026	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|promoter promoter|amod|END_ENTITY	The mycotoxin fumonisin_B1 transcriptionally activates the p21 promoter through a cis-acting element containing two Sp1 binding sites .
14729403	0	fumonisin_B1	64,76	protein_kinase_C_alpha	38,60	fumonisin B1	protein kinase C alpha	MESH:C056933	5578	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Selective and transient activation of protein_kinase_C_alpha by fumonisin_B1 , a ceramide synthase inhibitor mycotoxin , in cultured porcine renal cells .
25857260	0	fumosorinone	30,42	protein_tyrosine_phosphatase_1B	50,81	fumosorinone	protein tyrosine phosphatase 1B	null	5770	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Structure and biosynthesis of fumosorinone , a new protein_tyrosine_phosphatase_1B inhibitor firstly isolated from the entomogenous fungus Isaria fumosorosea .
8292742	0	furafylline	77,88	cytochrome_P450_1A2	54,73	furafylline	cytochrome P450 1A2	MESH:C050131	1544	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Isoform-selective mechanism-based inhibition of human cytochrome_P450_1A2 by furafylline .
16699068	0	furan-2-carboxylic_acid	40,63	cathepsin_K	17,28	furan-2-carboxylic acid	cathepsin K	CHEBI:30845	29175(Tax:10116)	Chemical	Gene	inhibitor|dep|START_ENTITY inhibitor|compound|END_ENTITY	An orally active cathepsin_K inhibitor , furan-2-carboxylic_acid , 1 - -LCB- 1 - -LSB- 4-fluoro-2 - -LRB- 2-oxo-pyrrolidin-1-yl -RRB- - phenyl -RSB- -3 - oxo-piperidin-4-ylcarbamoyl -RCB- - cyclohexyl -RRB- - amide -LRB- OST-4077 -RRB- , inhibits osteoclast activity in vitro and bone_loss in ovariectomized rats .
26160581	0	furaneol	55,63	glucosyltransferase	64,83	furaneol	glucosyltransferase	MESH:C058427	100247052(Tax:29760)	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Molecular cloning and characterization of UDP-glucose : furaneol glucosyltransferase gene from grapevine cultivar Muscat Bailey A -LRB- Vitis labrusca * V. _ vinifera -RRB- .
20041416	0	furanocoumarins	37,52	beta-secretase	0,14	furanocoumarins	beta-secretase	MESH:D011564	23621	Chemical	Gene	effects|nmod|START_ENTITY effects|amod|END_ENTITY	beta-secretase inhibitory effects of furanocoumarins from the root of Angelica dahurica .
10877530	0	furanocoumarins	29,44	cytochrome_P450_3A	65,83	furanocoumarins	cytochrome P450 3A	MESH:D011564	1576	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|amod|END_ENTITY	Inhibitory effect of natural furanocoumarins on human microsomal cytochrome_P450_3A activity .
18667267	0	furanodiene	26,37	TNFR1	83,88	furanodiene	TNFR1	MESH:C442489	7132	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of apoptosis by furanodiene in HL60 leukemia cells through activation of TNFR1 signaling pathway .
7157422	0	furans	26,32	N-acetylglucosaminidase	44,67	furans	N-acetylglucosaminidase	MESH:D005663	27419(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|levels levels|amod|END_ENTITY	The effect of nephrotoxic furans on urinary N-acetylglucosaminidase levels in mice .
18445497	0	furocoumarins	70,83	corticotrophin_releasing_factor	30,61	furocoumarins	corticotrophin releasing factor	MESH:D011564	12917(Tax:10090)	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Transcriptional regulation of corticotrophin_releasing_factor gene by furocoumarins isolated from seeds of Psoralea corylifolia .
8026000	0	furosemide	73,83	ACE	99,102	furosemide	ACE	MESH:D005665	1636	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|compound|END_ENTITY	Effect of intense angiotensin_II suppression on the diuretic response to furosemide during chronic ACE inhibition .
2534930	0	furosemide	11,21	ANP	73,76	furosemide	ANP	MESH:D005665	4878	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	-LSB- Effect of furosemide on the plasma level of atrial_natriuretic_peptide -LRB- ANP -RRB- in healthy persons and in patients with uncomplicated primary arterial_hypertension -RSB- .
19126296	0	furosemide	154,164	CYP2C11	125,132	furosemide	CYP2C11	MESH:D005665	29277(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY involvement|nmod|metabolism involvement|nmod|END_ENTITY	Effects of cytochrome_P450 inducers and inhibitors on the pharmacokinetics of intravenous furosemide in rats : involvement of CYP2C11 , 2E1 , 3A1 and 3A2 in furosemide metabolism .
8864301	0	furosemide	63,73	Fos	14,17	furosemide	Fos	MESH:D005665	314322(Tax:10116)	Chemical	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of Fos in rat brain in relation to sodium_appetite : furosemide and cerebroventricular renin .
842632	0	furosemide	23,33	PTH	43,46	furosemide	PTH	MESH:D005665	403986(Tax:9615)	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|role role|nmod|END_ENTITY	Phosphaturic effect of furosemide : role of PTH and carbonic anhydrase .
7021994	0	furosemide	20,30	Renin	0,5	furosemide	Renin	MESH:D005665	5972	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|END_ENTITY	Renin release after furosemide and ethacrynic_acid in man .
7023561	0	furosemide	24,34	Renin	0,5	furosemide	Renin	MESH:D005665	5972	Chemical	Gene	responsiveness|xcomp|START_ENTITY responsiveness|nsubj|END_ENTITY	Renin responsiveness to furosemide in the homotransplanted kidney .
7045443	0	furosemide	18,28	Renin	0,5	furosemide	Renin	MESH:D005665	5972	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Renin response to furosemide differs with the routes of administration in health men .
19709838	0	furosemide	15,25	albumin	43,50	furosemide	albumin	MESH:D005665	213	Chemical	Gene	Alterations|nmod|START_ENTITY Alterations|nmod|END_ENTITY	Alterations of furosemide binding to serum albumin induced by increased level of fatty_acid .
22751371	0	furosemide	42,52	albumin	10,17	furosemide	albumin	MESH:D005665	213	Chemical	Gene	Effect|acl|START_ENTITY Effect|nmod|END_ENTITY	Effect of albumin on diuretic response to furosemide in patients with hypoalbuminemia .
8065233	0	furosemide	100,110	angiotensin_II_type_1_receptor	10,40	furosemide	angiotensin II type 1 receptor	MESH:D005665	81638(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|antagonist antagonist|amod|END_ENTITY	Effect of angiotensin_II_type_1_receptor antagonist on urinary prostaglandin_E2 excretion following furosemide in rats .
8296708	0	furosemide	58,68	atrial_natriuretic_factor	27,52	furosemide	atrial natriuretic factor	MESH:D005665	4878	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of intravenous atrial_natriuretic_factor with furosemide in patients with heart_failure .
11046100	0	furosemide	61,71	bradykinin	11,21	furosemide	bradykinin	MESH:D005665	3827	Chemical	Gene	responses|xcomp|START_ENTITY responses|nsubj|END_ENTITY	Endogenous bradykinin and the renin and pressor responses to furosemide in humans .
2874909	0	furosemide	11,21	insulin	53,60	furosemide	insulin	MESH:D005665	483665(Tax:9615)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of furosemide and indapamide upon pancreatic insulin and somatostatin secretion in vitro .
6998800	0	furosemide	10,20	insulin	24,31	furosemide	insulin	MESH:D005665	3630	Chemical	Gene	START_ENTITY|nmod|responses responses|compound|END_ENTITY	Effect of furosemide on insulin and glucagon responses to arginine in normal subjects .
2087934	0	furosemide	82,92	kallikrein	34,44	furosemide	kallikrein	MESH:D005665	9622	Chemical	Gene	renin|nmod|START_ENTITY renin|dobj|excretion excretion|compound|END_ENTITY	Plasma renin activity and urinary kallikrein excretion in response to intravenous furosemide in diabetic patients .
3549580	0	furosemide	16,26	kallikrein	36,46	furosemide	kallikrein	MESH:D005665	9622	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Acute effect of furosemide on renal kallikrein and prostaglandin systems in mild to moderate essential hypertension .
489923	0	furosemide	58,68	kallikrein	21,31	furosemide	kallikrein	MESH:D005665	9622	Chemical	Gene	Relationship|nmod|START_ENTITY Relationship|nmod|END_ENTITY	Relationship between kallikrein and PRA after intravenous furosemide .
6160345	0	furosemide	62,72	kallikrein	15,25	furosemide	kallikrein	MESH:D005665	9622	Chemical	Gene	Involvement|acl|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of kallikrein in the antihypertensive response to furosemide in essential hypertension .
3947689	0	furosemide	88,98	prolactin	7,16	furosemide	prolactin	MESH:D005665	5617	Chemical	Gene	response|acl|START_ENTITY levels|dep|response levels|compound|END_ENTITY	Plasma prolactin levels in full-term newborn infants with idiopathic edema : response to furosemide .
905911	0	furosemide	14,24	prolactin	34,43	furosemide	prolactin	MESH:D005665	5617	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|levels levels|compound|END_ENTITY	The effect of furosemide on serum prolactin levels in the postpartum period .
1022409	0	furosemide	14,24	renin	40,45	furosemide	renin	MESH:D005665	5972	Chemical	Gene	stimulation|amod|START_ENTITY stimulation|nmod|secretion secretion|compound|END_ENTITY	The effect of furosemide stimulation on renin secretion and its application in examining activity of the renin-angiotensin system .
1135521	0	furosemide	86,96	renin	27,32	furosemide	renin	MESH:D005665	5972	Chemical	Gene	subjects|amod|START_ENTITY elevation|nmod|subjects elevation|nmod|activity activity|compound|END_ENTITY	Marked elevation of plasma renin activity during post diuretic sodium conservation in furosemide stimulated subjects .
11549664	0	furosemide	89,99	renin	174,179	furosemide	renin	MESH:D005665	5972	Chemical	Gene	posture|amod|START_ENTITY posture|acl|screening screening|nmod|adenoma adenoma|nmod|hypertensives hypertensives|compound|END_ENTITY	Performance of the basal aldosterone to renin ratio and of the renin stimulation test by furosemide and upright posture in screening for aldosterone-producing adenoma in low renin hypertensives .
11549664	0	furosemide	89,99	renin	40,45	furosemide	renin	MESH:D005665	5972	Chemical	Gene	posture|amod|START_ENTITY test|nmod|posture test|nsubj|Performance Performance|nmod|aldosterone aldosterone|nmod|ratio ratio|compound|END_ENTITY	Performance of the basal aldosterone to renin ratio and of the renin stimulation test by furosemide and upright posture in screening for aldosterone-producing adenoma in low renin hypertensives .
1257693	0	furosemide	50,60	renin	17,22	furosemide	renin	MESH:D005665	5972	Chemical	Gene	increase|nmod|START_ENTITY increase|nsubj|END_ENTITY	Unimpeded plasma renin increase after intravenous furosemide during saline replacement .
12620696	0	furosemide	17,27	renin	81,86	furosemide	renin	MESH:D005665	5972	Chemical	Gene	Effectiveness|nmod|START_ENTITY Effectiveness|dep|role role|nmod|profiling profiling|compound|END_ENTITY	Effectiveness of furosemide in uncontrolled hypertension in the elderly : role of renin profiling .
172005	0	furosemide	11,21	renin	41,46	furosemide	renin	MESH:D005665	5972	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|compound|END_ENTITY	-LSB- Effect of furosemide and ACTH on plasma renin , aldosterone and cortisol levels in normal man -RSB- .
19035874	0	furosemide	73,83	renin	42,47	furosemide	renin	MESH:D005665	5972	Chemical	Gene	isosorbide-5-mononitrate|amod|START_ENTITY aliskiren|nmod|isosorbide-5-mononitrate aliskiren|nsubj|interaction interaction|nmod|inhibitor inhibitor|compound|END_ENTITY	Pharmacokinetic interaction of the direct renin inhibitor aliskiren with furosemide and extended-release isosorbide-5-mononitrate in healthy subjects .
2266774	0	furosemide	76,86	renin	67,72	furosemide	renin	MESH:D005665	5972	Chemical	Gene	glycosylated|nmod|START_ENTITY glycosylated|dobj|forms forms|nmod|END_ENTITY	Disproportional release of differently glycosylated forms of human renin by furosemide .
2677316	0	furosemide	43,53	renin	25,30	furosemide	renin	MESH:D005665	24715(Tax:10116)	Chemical	Gene	potentiates|xcomp|START_ENTITY potentiates|dobj|response response|compound|END_ENTITY	Caffeine potentiates the renin response to furosemide in rats .
3276725	0	furosemide	88,98	renin	36,41	furosemide	renin	MESH:D005665	5972	Chemical	Gene	effects|nmod|START_ENTITY renin|dep|effects renin|appos|END_ENTITY	Plasma renin and prorenin -LRB- inactive renin -RRB- in diabetes_mellitus : effects of intravenous furosemide .
3276725	0	furosemide	88,98	renin	7,12	furosemide	renin	MESH:D005665	5972	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|dep|effects	Plasma renin and prorenin -LRB- inactive renin -RRB- in diabetes_mellitus : effects of intravenous furosemide .
3549504	0	furosemide	121,131	renin	24,29	furosemide	renin	MESH:D005665	5972	Chemical	Gene	administration|amod|START_ENTITY changes|nmod|administration changes|nmod|concentration concentration|compound|END_ENTITY	Acute changes in plasma renin activity , plasma aldosterone concentration and plasma electrolyte concentrations following furosemide administration in patients with congestive_heart_failure -- interrelationships and diuretic response .
3553421	0	furosemide	81,91	renin	28,33	furosemide	renin	MESH:D005665	5972	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|modeling modeling|nmod|aldosterone aldosterone|amod|END_ENTITY	System dynamics modeling of renin aldosterone and electrolyte changes induced by furosemide in hypertensive patients .
424524	0	furosemide	11,21	renin	45,50	furosemide	renin	MESH:D005665	5972	Chemical	Gene	Effects|nmod|START_ENTITY plasma|nsubj|Effects plasma|dobj|activity activity|compound|END_ENTITY	Effects of furosemide on renal venous plasma renin activity .
449049	0	furosemide	61,71	renin	17,22	furosemide	renin	MESH:D005665	5972	Chemical	Gene	administration|compound|START_ENTITY substrate|nmod|administration substrate|nsubj|Change Change|nmod|END_ENTITY	Change in plasma renin substrate level after the intravenous furosemide administration .
568077	0	furosemide	84,94	renin	11,16	furosemide	renin	MESH:D005665	403838(Tax:9615)	Chemical	Gene	-RSB-|amod|START_ENTITY influence|nmod|-RSB- dogs|nmod|influence plasma|nmod|dogs Change|nmod|plasma Change|nmod|activity activity|compound|END_ENTITY	-LSB- Change in renin activity in the venous blood plasma of dogs under the influence of furosemide , novurit , ethacrynic_acid and mannitol -RSB- .
6388913	0	furosemide	65,75	renin	43,48	furosemide	renin	MESH:D005665	5972	Chemical	Gene	changes|nmod|START_ENTITY changes|nmod|secretion secretion|compound|END_ENTITY	Synchronous changes in active and inactive renin secretion after furosemide in patients with primary_aldosteronism .
6459589	0	furosemide	54,64	renin	30,35	furosemide	renin	MESH:D005665	5972	Chemical	Gene	stimulation|amod|START_ENTITY activity|nmod|stimulation activity|compound|END_ENTITY	Response of peripheral plasma renin activity -LRB- PRA -RRB- to furosemide stimulation ; reduction_of_the_renal_parenchyma as a limiting factor .
6749346	0	furosemide	47,57	renin	9,14	furosemide	renin	MESH:D005665	5972	Chemical	Gene	discontinuation|nmod|START_ENTITY levels|nmod|discontinuation levels|compound|END_ENTITY	Enhanced renin levels after discontinuation of furosemide : additional effects of loop diuretics on renin release .
6749346	0	furosemide	47,57	renin	99,104	furosemide	renin	MESH:D005665	5972	Chemical	Gene	discontinuation|nmod|START_ENTITY levels|nmod|discontinuation levels|dep|effects effects|nmod|diuretics diuretics|nmod|release release|compound|END_ENTITY	Enhanced renin levels after discontinuation of furosemide : additional effects of loop diuretics on renin release .
6785094	0	furosemide	11,21	renin	61,66	furosemide	renin	MESH:D005665	5972	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of furosemide and orthostasis on active and inactive renin in normal and anephric man .
6991284	0	furosemide	40,50	renin	83,88	furosemide	renin	MESH:D005665	403838(Tax:9615)	Chemical	Gene	Mechanism|nmod|START_ENTITY Mechanism|nmod|END_ENTITY	-LSB- Mechanism of the stimulating effect of furosemide , ethacrynic_acid and novurit on renin secretion by the kidneys -RSB- .
7005123	0	furosemide	59,69	renin	12,17	furosemide	renin	MESH:D005665	5972	Chemical	Gene	combination|amod|START_ENTITY Response|nmod|combination Response|nmod|END_ENTITY	Response of renin , aldosterone and antidiuretic_hormone to furosemide and furosemide-triamterene combination .
7026261	0	furosemide	52,62	renin	32,37	furosemide	renin	MESH:D005665	5972	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|Lack Lack|nmod|influence influence|nmod|END_ENTITY	Lack of adrenergic influence on renin release after furosemide in normal man .
7607716	0	furosemide	11,21	renin	84,89	furosemide	renin	MESH:D005665	100358545(Tax:9986)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of furosemide and verapamil on the NaCl dependency of macula densa-mediated renin secretion .
7910062	0	furosemide	44,54	renin	20,25	furosemide	renin	MESH:D005665	5972	Chemical	Gene	responsiveness|xcomp|START_ENTITY responsiveness|nsubj|Correlation Correlation|nmod|END_ENTITY	Correlation between renin responsiveness to furosemide and antihypertensive effect of captopril in patients with normal-renin essential hypertension .
8418022	0	furosemide	59,69	renin	36,41	furosemide	renin	MESH:D005665	24715(Tax:10116)	Chemical	Gene	RNA|nmod|START_ENTITY RNA|nsubj|course course|nmod|stimulation stimulation|nmod|messenger messenger|compound|END_ENTITY	Time course of stimulation of renal renin messenger RNA by furosemide .
8738111	0	furosemide	48,58	renin	20,25	furosemide	renin	MESH:D005665	100724037	Chemical	Gene	stimulated|nmod|START_ENTITY release|acl|stimulated release|compound|END_ENTITY	Captopril increases renin release stimulated by furosemide and hypotension in isolated perfused guinea_pig kidneys .
937875	0	furosemide	16,26	renin	58,63	furosemide	renin	MESH:D005665	5972	Chemical	Gene	test|compound|START_ENTITY test|dep|way way|acl|evaluate evaluate|dobj|responsiveness responsiveness|compound|END_ENTITY	The intravenous furosemide test : a simple way to evaluate renin responsiveness .
1081203	0	furosemide	11,21	vasopressin	106,117	furosemide	vasopressin	MESH:D005665	551	Chemical	Gene	skin|amod|START_ENTITY Effects|nmod|skin Effects|dep|comparison comparison|nmod|END_ENTITY	Effects of furosemide on sodium content and transport pool in frog skin -LRB- Rana esculenta -RRB- : comparison with vasopressin and ouabain .
1295687	0	furosemide	87,97	vasopressin	10,21	furosemide	vasopressin	MESH:D005665	551	Chemical	Gene	exhibit|dobj|START_ENTITY level|dep|exhibit brain_swelling|nmod|level END_ENTITY|acl|brain_swelling	Effect of vasopressin on brain_swelling at the cellular level : do astrocytes exhibit a furosemide -- vasopressin-sensitive mechanism for volume regulation ?
3716880	0	furosemide	49,59	vasopressin	9,20	furosemide	vasopressin	MESH:D005665	551	Chemical	Gene	response|acl|START_ENTITY response|amod|END_ENTITY	Abnormal vasopressin and aldosterone response to furosemide in essential hypertension .
2403855	0	furylfuramide	26,39	cytochrome_P450	43,58	furylfuramide	cytochrome P450	MESH:D005668	4051	Chemical	Gene	deactivation|nmod|START_ENTITY deactivation|nmod|END_ENTITY	Metabolic deactivation of furylfuramide by cytochrome_P450 in human and rat liver microsomes .
2423643	0	fusaric_acid	45,57	DBH	61,64	fusaric acid	DBH	MESH:D005669	25699(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Peripheral and central short-term effects of fusaric_acid , a DBH inhibitor , on tryptophan and serotonin metabolism in the rat .
7354907	0	fusaric_acid	63,75	dopamine-beta-hydroxylase	79,104	fusaric acid	dopamine-beta-hydroxylase	MESH:D005669	1621	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	24-hour rhythm of human plasma noradrenaline and the effect of fusaric_acid , a dopamine-beta-hydroxylase inhibitor .
3987067	0	fusaric_acid	10,22	dopamine_beta-hydroxylase	26,51	fusaric acid	dopamine beta-hydroxylase	MESH:D005669	1621	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|inhibitor inhibitor|amod|END_ENTITY	Effect of fusaric_acid -LRB- a dopamine_beta-hydroxylase inhibitor -RRB- on phaeochromocytoma .
1344894	0	fusarochromanones	28,45	TDP-1	46,51	fusarochromanones	TDP-1	null	517053(Tax:9913)	Chemical	Gene	effects|nmod|START_ENTITY effects|amod|END_ENTITY	Immunomodulatory effects of fusarochromanones TDP-1 and TDP-2 .
27001509	0	fusidic_acid	13,25	RRF	40,43	fusidic acid	RRF	MESH:D005672	92399	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Mechanism of fusidic_acid inhibition of RRF - and EF-G-dependent splitting of the bacterial post-termination ribosome .
15909954	0	g-hydroxybutyric_acid	65,86	acetylcholinesterase	100,120	g-hydroxybutyric acid	acetylcholinesterase	null	43	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Synthesis of novel N-alkyl_carbamates of a-substituted_amides of g-hydroxybutyric_acid as potential acetylcholinesterase inhibitors .
7121708	0	gabaculine	83,93	GABA-T	65,71	gabaculine	GABA-T	MESH:C012987	81632(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Turnover and release of GABA in rat cortical slices : effect of a GABA-T inhibitor , gabaculine .
7914662	0	gabaculine	62,72	GABA-transaminase	30,47	gabaculine	GABA-transaminase	MESH:C012987	81632(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Measurement of GABA following GABA-transaminase inhibition by gabaculine : a 1H and 31P NMR spectroscopic study of rat brain in vivo .
10482450	0	gabaculine	109,119	gamma-aminobutyric_acid_aminotransferase	65,105	gabaculine	gamma-aminobutyric acid aminotransferase	MESH:C012987	18	Chemical	Gene	Isolation|nmod|START_ENTITY Isolation|nmod|END_ENTITY	Isolation and characterization of the product of inactivation of gamma-aminobutyric_acid_aminotransferase by gabaculine .
23567998	0	gabapentin	13,23	LAT1	27,31	gabapentin	LAT1	MESH:C040029	8140	Chemical	Gene	Transport|nmod|START_ENTITY Transport|nmod|END_ENTITY	Transport of gabapentin by LAT1 -LRB- SLC7A5 -RRB- .
19157422	0	gabapentin	64,74	Spinocerebellar_ataxia_type_6	0,29	gabapentin	Spinocerebellar ataxia type 6	MESH:C040029	773	Chemical	Gene	trial|nmod|START_ENTITY END_ENTITY|dep|trial	Spinocerebellar_ataxia_type_6 -LRB- SCA6 -RRB- : clinical pilot trial with gabapentin .
17873368	0	gabapentin	10,20	c-Fos	24,29	gabapentin	c-Fos	MESH:C040029	314322(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of gabapentin on c-Fos expression in the CNS after paw surgery in rats .
23399960	0	gabapentin	12,22	interleukin-10	33,47	gabapentin	interleukin-10	MESH:C040029	25325(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Intrathecal gabapentin increases interleukin-10 expression and inhibits pro-inflammatory cytokine in a rat model of neuropathic_pain .
10654583	0	gabazine	37,45	CA3	81,84	gabazine	CA3	MESH:C049853	54232(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY hippocampal|nsubj|effects hippocampal|dobj|area area|compound|END_ENTITY	Differential paired-pulse effects of gabazine and bicuculline in rat hippocampal CA3 area .
6194983	0	gabexate_mesilate	34,51	phospholipase_A2	14,30	gabexate mesilate	phospholipase A2	MESH:D016670	151056	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of phospholipase_A2 by gabexate_mesilate , camostate and aprotinine .
945070	0	gadolinium	32,42	Phospholipase_A2	0,16	gadolinium	Phospholipase A2	MESH:D005682	151056	Chemical	Gene	complexes|nmod|START_ENTITY complexes|amod|END_ENTITY	Phospholipase_A2 complexes with gadolinium -LRB- III -RRB- and interaction of the enzyme-metal ion complex with monomeric and micellar alkylphosphorylcholines .
15614134	0	gadolinium_chloride	90,109	tumor_necrosis_factor-alpha	29,56	gadolinium chloride	tumor necrosis factor-alpha	MESH:C038958	21926(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|production production|amod|END_ENTITY	Opposite effects of enhanced tumor_necrosis_factor-alpha production from Kupffer cells by gadolinium_chloride on liver_injury / mortality in endotoxemia of normal and partially hepatectomized mice .
12906872	0	galactosamine	71,84	tumor_necrosis_factor	29,50	galactosamine	tumor necrosis factor	MESH:D005688	21926(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nmod|END_ENTITY	Bilirubin release induced by tumor_necrosis_factor in combination with galactosamine is toxic to mice .
20627950	0	galactose	56,65	AtSTP14	39,46	galactose	AtSTP14	MESH:D005690	844057(Tax:3702)	Chemical	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification and characterization of AtSTP14 , a novel galactose transporter from Arabidopsis .
11442726	0	galactose	10,19	CRL	134,137	galactose	CRL	MESH:D005690	133396	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of galactose and glucose on the exopolysaccharide production and the activities of biosynthetic enzymes in Lactobacillus casei CRL 87 .
1924965	0	galactose	33,42	DTNB	10,14	galactose	DTNB	MESH:D005690	362715(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of DTNB on rat intestinal galactose transport in vivo .
10862881	0	galactose	70,79	GAL2	13,17	galactose	GAL2	MESH:D005690	850770(Tax:4932)	Chemical	Gene	produced|nmod|START_ENTITY repression|acl|produced alleviate|dobj|repression alleviate|nsubj|Mutations Mutations|nmod|END_ENTITY	Mutations in GAL2 or GAL4 alleviate catabolite repression produced by galactose in Saccharomyces_cerevisiae .
3082856	0	galactose	47,56	GAL2	0,4	galactose	GAL2	MESH:D005690	850770(Tax:4932)	Chemical	Gene	subunit|nmod|START_ENTITY codes|nmod|subunit codes|nummod|END_ENTITY	GAL2 codes for a membrane-bound subunit of the galactose permease in Saccharomyces_cerevisiae .
428694	0	galactose	19,28	GIP	32,35	galactose	GIP	MESH:D005690	2695	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of oral galactose on GIP and insulin secretion in man .
17253981	0	galactose	49,58	Gal10p	105,111	galactose	Gal10p	MESH:D005690	852307(Tax:4932)	Chemical	Gene	START_ENTITY|dobj|protein protein|appos|END_ENTITY	Characterization of the Saccharomyces_cerevisiae galactose mutarotase/UDP-galactose 4-epimerase protein , Gal10p .
10660614	0	galactose	48,57	Gal2	77,81	galactose	Gal2	MESH:D005690	850770(Tax:4932)	Chemical	Gene	transport|amod|START_ENTITY transport|nmod|END_ENTITY	Three aromatic amino_acid residues critical for galactose transport in yeast Gal2 transporter .
7852299	0	galactose	41,50	Gal2	36,40	galactose	Gal2	MESH:D005690	850770(Tax:4932)	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	Substrate recognition domain of the Gal2 galactose transporter in yeast Saccharomyces_cerevisiae as revealed by chimeric galactose-glucose transporters .
9201972	0	galactose	36,45	Gal2	67,71	galactose	Gal2	MESH:D005690	850770(Tax:4932)	Chemical	Gene	recognition|amod|START_ENTITY recognition|nmod|END_ENTITY	Amino_acid residues responsible for galactose recognition in yeast Gal2 transporter .
15081399	0	galactose	76,85	PKC_and_PKA	15,26	galactose	PKC and PKA	MESH:D005690	24681(Tax:10116)	Chemical	Gene	absorption|compound|START_ENTITY Involvement|nmod|absorption Involvement|nmod|END_ENTITY	Involvement of PKC_and_PKA in the inhibitory effect of leptin on intestinal galactose absorption .
11092512	0	galactose	7,16	galactose-1-phosphate_uridyltransferase	63,102	galactose	galactose-1-phosphate uridyltransferase	MESH:D005690	2592	Chemical	Gene	START_ENTITY|dobj|concentration concentration|nmod|patients patients|nmod|deficiency_galactosemia deficiency_galactosemia|amod|END_ENTITY	Plasma galactose and galactitol concentration in patients with galactose-1-phosphate_uridyltransferase deficiency_galactosemia : determination by gas chromatography/mass spectrometry .
11286505	0	galactose	23,32	galactose-1-phosphate_uridyltransferase	77,116	galactose	galactose-1-phosphate uridyltransferase	MESH:D005690	2592	Chemical	Gene	oxidation|compound|START_ENTITY Evidence|nmod|oxidation Evidence|nmod|gene gene|amod|END_ENTITY	Evidence for alternate galactose oxidation in a patient with deletion of the galactose-1-phosphate_uridyltransferase gene .
7957929	0	galactose	22,31	galactose-1-phosphate_uridyltransferase	35,74	galactose	galactose-1-phosphate uridyltransferase	MESH:D005690	2592	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Regulatory effects of galactose on galactose-1-phosphate_uridyltransferase activity on human hepatoblastoma HepG2 cells .
8260558	0	galactose	45,54	galactose-1-phosphate_uridyltransferase	67,106	galactose	galactose-1-phosphate uridyltransferase	MESH:D005690	2592	Chemical	Gene	metabolism|compound|START_ENTITY model|nmod|metabolism guinea_pig|nmod|model guinea_pig|dep|activity activity|amod|END_ENTITY	The neonatal guinea_pig as a model for human galactose metabolism : galactose-1-phosphate_uridyltransferase activity .
17981065	0	galactose-1P	18,30	GALT	123,127	galactose-1P	GALT	null	2592	Chemical	Gene	_|amod|START_ENTITY _|appos|END_ENTITY	Distinct roles of galactose-1P in galactose-mediated_growth_arrest of yeast deficient_in_galactose-1P_uridylyltransferase _ -LRB- GALT -RRB- _ and_UDP-galactose_4 ' - epimerase -LRB- GALE -RRB- .
6226317	0	galactosyl	30,40	beta-hexosaminidase	73,92	galactosyl	beta-hexosaminidase	null	10724	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Effect of the co-existence of galactosyl and phosphomannosyl residues on beta-hexosaminidase on the processing and transport of the enzyme in mucolipidosis_I fibroblasts .
24294900	0	galactosyl-3-sulfate_ceramide	86,115	arylsulfatase_a	54,69	galactosyl-3-sulfate ceramide	arylsulfatase a	null	410	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	A new analytical bench assay for the determination of arylsulfatase_a activity toward galactosyl-3-sulfate_ceramide : implication for metachromatic_leukodystrophy diagnosis .
6766828	0	galactosylceramide	62,80	beta-galactosidase	103,121	galactosylceramide	beta-galactosidase	CHEBI:36498	2720	Chemical	Gene	activities|amod|START_ENTITY activities|amod|END_ENTITY	A comparison of the properties and bile_salt specificities of galactosylceramide and lactosyl_ceramide beta-galactosidase activities in human leucocytes and fibroblasts .
7929093	0	galactosylceramide	82,100	gp120	73,78	galactosylceramide	gp120	CHEBI:36498	155971(Tax:11676)	Chemical	Gene	binding|nmod|START_ENTITY binding|nmod|END_ENTITY	Suramin inhibits binding of the V3 region of HIV-1 envelope glycoprotein gp120 to galactosylceramide , the receptor for HIV-1 gp120 on human colon epithelial cells .
7030453	0	galactosylceramide	39,57	jimpy	20,25	galactosylceramide	jimpy	CHEBI:36498	18823(Tax:10090)	Chemical	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Oligodendrocytes of jimpy mice express galactosylceramide : an immunofluorescence study on brain sections and dissociated brain cell cultures .
25270721	0	galangin	29,37	ERK	86,89	galangin	ERK	MESH:C037032	26413(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Anti-inflammatory effects of galangin on lipopolysaccharide-activated macrophages via ERK and NF-kB pathway regulation .
24059300	0	galangin	76,84	acetylcholinesterase	105,125	galangin	acetylcholinesterase	MESH:C037032	43	Chemical	Gene	START_ENTITY|nmod|brain brain|amod|END_ENTITY	Prediction of comparative inhibition efficiency for a novel natural ligand , galangin against human brain acetylcholinesterase , butyrylcholinesterase and 5-lipoxygenase : a neuroinformatics study .
12915763	0	galanin	28,35	Gal-r1	105,111	galanin	Gal-r1	MESH:D019004	50577(Tax:10116)	Chemical	Gene	action|nmod|START_ENTITY neurones|nsubj|action neurones|xcomp|expressing expressing|dobj|mRNA mRNA|compound|END_ENTITY	Direct inhibitory action of galanin on hypothalamic arcuate nucleus neurones expressing galanin receptor Gal-r1 mRNA .
12915763	0	galanin	88,95	Gal-r1	105,111	galanin	Gal-r1	MESH:D019004	50577(Tax:10116)	Chemical	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	Direct inhibitory action of galanin on hypothalamic arcuate nucleus neurones expressing galanin receptor Gal-r1 mRNA .
9516063	0	galanin	49,56	Growth_hormone	0,14	galanin	Growth hormone	MESH:D019004	2688	Chemical	Gene	infusion|compound|START_ENTITY END_ENTITY|nmod|infusion	Growth_hormone secretory response to intravenous galanin infusion in acromegalic patients .
11458203	0	galanin	33,40	VIP	76,79	galanin	VIP	MESH:D019004	117064(Tax:10116)	Chemical	Gene	peptide|amod|START_ENTITY peptide|appos|END_ENTITY	Effects of neuropeptide_Y -LRB- NPY -RRB- , galanin and vasoactive intestinal peptide -LRB- VIP -RRB- on pituitary hormone release and on ovarian steroidogenesis .
2466671	0	galanin	30,37	gastrin	85,92	galanin	gastrin	MESH:D019004	100685087	Chemical	Gene	effects|nmod|START_ENTITY analysis|nmod|effects analysis|nmod|secretion secretion|nmod|END_ENTITY	An analysis of the effects of galanin on gastric_acid secretion and plasma levels of gastrin in the dog .
1283383	0	galanin	22,29	growth_hormone	56,70	galanin	growth hormone	MESH:D019004	2688	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|response response|amod|END_ENTITY	Comparative effect of galanin and pyridostigmine on the growth_hormone response to growth_hormone-releasing hormone in normal aged subjects .
1699689	0	galanin	14,21	growth_hormone	51,65	galanin	growth hormone	MESH:D019004	2688	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|compound|END_ENTITY	The effect of galanin on baseline and GHRH-induced growth_hormone secretion in obese children .
2460722	0	galanin	69,76	growth_hormone	42,56	galanin	growth hormone	MESH:D019004	2688	Chemical	Gene	effect|acl|START_ENTITY effect|nmod|blockade blockade|nmod|response response|amod|END_ENTITY	The effect of cholinergic blockade on the growth_hormone response to galanin in humans .
7508379	0	galanin	72,79	growth_hormone	45,59	galanin	growth hormone	MESH:D019004	2688	Chemical	Gene	Effects|acl|START_ENTITY Effects|nmod|metoclopramide metoclopramide|nmod|response response|compound|END_ENTITY	Effects of metoclopramide on the paradoxical growth_hormone response to galanin in acromegaly .
7519979	0	galanin	41,48	growth_hormone	72,86	galanin	growth hormone	MESH:D019004	2688	Chemical	Gene	administration|nmod|START_ENTITY Effect|nmod|administration END_ENTITY|nsubj|Effect	Effect of the combined administration of galanin and clonidine on serum growth_hormone levels in normal subjects and in patients under chronic glucocorticoid treatment .
7680832	0	galanin	83,90	growth_hormone	56,70	galanin	growth hormone	MESH:D019004	2688	Chemical	Gene	Effect|acl|START_ENTITY Effect|nmod|treatment treatment|nmod|bromocriptine bromocriptine|nmod|response response|amod|END_ENTITY	Effect of long-term treatment with bromocriptine on the growth_hormone response to galanin in patients with acromegaly .
7692338	0	galanin	10,17	growth_hormone	60,74	galanin	growth hormone	MESH:D019004	2688	Chemical	Gene	Effect|nmod|START_ENTITY treated|nsubj|Effect treated|nmod|secretion secretion|amod|END_ENTITY	Effect of galanin and arginine , alone or in combination , on growth_hormone secretion in adult patients treated with glucocorticoids .
2458006	0	galanin	11,18	insulin	37,44	galanin	insulin	MESH:D019004	483665(Tax:9615)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|release release|nmod|END_ENTITY	Effects of galanin on the release of insulin , glucagon and somatostatin from the isolated , perfused dog pancreas .
2437498	0	galanin	8,15	prolactin	37,46	galanin	prolactin	MESH:D019004	24683(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|compound|END_ENTITY	Central galanin stimulates pituitary prolactin secretion in rats : possible involvement of hypothalamic vasoactive intestinal polypeptide .
15380373	0	galantamine	21,32	acetylcholinesterase	138,158	galantamine	acetylcholinesterase	MESH:D005702	11423(Tax:10090)	Chemical	Gene	treatment|compound|START_ENTITY Effect|nmod|treatment subtypes|nsubj|Effect subtypes|nmod|transgenic_mice transgenic_mice|acl|overexpressing overexpressing|dobj|END_ENTITY	Effect of subchronic galantamine treatment on neuronal nicotinic and muscarinic receptor subtypes in transgenic_mice overexpressing human acetylcholinesterase .
15496314	0	galantamine	47,58	acetylcholinesterase	69,89	galantamine	acetylcholinesterase	MESH:D005702	83817(Tax:10116)	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Enhancement of purinergic neurotransmission by galantamine and other acetylcholinesterase inhibitors in the rat vas deferens .
16144975	0	galantamine	72,83	acetylcholinesterase	40,60	galantamine	acetylcholinesterase	MESH:D005702	43	Chemical	Gene	donepezil|amod|START_ENTITY neuroprotection|amod|donepezil neuroprotection|acl|afforded afforded|nmod|inhibitors inhibitors|amod|END_ENTITY	Unequal neuroprotection afforded by the acetylcholinesterase inhibitors galantamine , donepezil , and rivastigmine in SH-SY5Y neuroblastoma cells : role of nicotinic receptors .
17159811	0	galantamine	10,21	acetylcholinesterase	25,45	galantamine	acetylcholinesterase	MESH:D005702	83817(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activities activities|amod|END_ENTITY	Effect of galantamine on acetylcholinesterase and butyrylcholinesterase activities in the presence of L-carnitine in rat selected brain and peripheral tissues .
17196712	0	galantamine	107,118	acetylcholinesterase	14,34	galantamine	acetylcholinesterase	MESH:D005702	43	Chemical	Gene	treated|nmod|START_ENTITY Inhibition|acl|treated Inhibition|nmod|END_ENTITY	Inhibition of acetylcholinesterase in CSF versus brain assessed by 11C-PMP PET in AD patients treated with galantamine .
22207414	0	galantamine	196,207	acetylcholinesterase	58,78	galantamine	acetylcholinesterase	MESH:D005702	43	Chemical	Gene	subjects|nmod|START_ENTITY extract|nmod|subjects END_ENTITY|parataxis|extract	Mixed-effect circadian rhythm model for human erythrocyte acetylcholinesterase activity -- application to the proof of concept of cholinesterase inhibition by acorn extract in healthy subjects with galantamine as positive control .
25979761	0	galantamine	57,68	acetylcholinesterase	73,93	galantamine	acetylcholinesterase	MESH:D005702	11423(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY and|dep|effects and|appos|inhibitor inhibitor|amod|END_ENTITY	Nicotinic receptor-dependent and - independent effects of galantamine , an acetylcholinesterase inhibitor , on the non-neuronal acetylcholine system in C2C12 cells .
25979761	0	galantamine	57,68	acetylcholinesterase	73,93	galantamine	acetylcholinesterase	MESH:D005702	11423(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY and|dep|effects and|appos|inhibitor inhibitor|amod|END_ENTITY	Nicotinic receptor-dependent and - independent effects of galantamine , an acetylcholinesterase inhibitor , on the non-neuronal acetylcholine system in C2C12 cells .
15834443	0	galantamine	10,21	alpha7_neuronal_nicotinic_acetylcholine_receptor	35,83	galantamine	alpha7 neuronal nicotinic acetylcholine receptor	MESH:D005702	1139	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of galantamine on the human alpha7_neuronal_nicotinic_acetylcholine_receptor , the Torpedo nicotinic_acetylcholine_receptor and spontaneous cholinergic synaptic activity .
21872646	0	galantamine	51,62	butyrylcholinesterase	26,47	galantamine	butyrylcholinesterase	MESH:D005702	590	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Synergistic inhibition of butyrylcholinesterase by galantamine and citalopram .
10399139	0	galanthamine	45,57	acetylcholinesterase	14,34	galanthamine	acetylcholinesterase	MESH:D005702	83817(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|inhibitor inhibitor|amod|END_ENTITY	Effect of the acetylcholinesterase inhibitor galanthamine on learning and memory in prolonged alcohol intake rat model of acetylcholine deficit .
11449566	0	galanthamine	49,61	acetylcholinesterase	104,124	galanthamine	acetylcholinesterase	MESH:D005702	43	Chemical	Gene	conformation|nmod|START_ENTITY prediction|nmod|conformation END_ENTITY|nsubj|prediction	Accurate prediction of the bound conformation of galanthamine in the active site of Torpedo californica acetylcholinesterase using molecular docking .
15563167	0	galanthamine	40,52	acetylcholinesterase	66,86	galanthamine	acetylcholinesterase	MESH:D005702	43	Chemical	Gene	START_ENTITY|nmod|displays displays|compound|END_ENTITY	The complex of a bivalent derivative of galanthamine with torpedo acetylcholinesterase displays drastic_deformation of the active-site gorge : implications for structure-based drug design .
1954303	0	galanthamine	86,98	acetylcholinesterase	14,34	galanthamine	acetylcholinesterase	MESH:D005702	11423(Tax:10090)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activity activity|amod|END_ENTITY	Inhibition of acetylcholinesterase activity in human brain tissue and erythrocytes by galanthamine , physostigmine and tacrine .
2274601	0	galanthamine	30,42	acetylcholinesterase	58,78	galanthamine	acetylcholinesterase	MESH:D005702	11423(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Effects of different doses of galanthamine , a long-acting acetylcholinesterase inhibitor , on memory in mice .
2999623	0	galanthamine	132,144	acetylcholinesterase	106,126	galanthamine	acetylcholinesterase	MESH:D005702	83817(Tax:10116)	Chemical	Gene	-RSB-|amod|START_ENTITY currents|nmod|-RSB- currents|nmod|END_ENTITY	-LSB- Miniature currents of the endplates of the muscle fibers of the diaphragm of the rat after inhibition of acetylcholinesterase with galanthamine -RSB- .
3390582	0	galanthamine	74,86	acetylcholinesterase	37,57	galanthamine	acetylcholinesterase	MESH:D005702	83817(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	-LSB- Quantitative estimation of synaptic acetylcholinesterase inhibition with galanthamine using parameters of miniature endplate currents -RSB- .
8627552	0	galanthamine	113,125	acetylcholinesterase	70,90	galanthamine	acetylcholinesterase	MESH:D005702	83817(Tax:10116)	Chemical	Gene	related|xcomp|START_ENTITY inhibitors|acl|related inhibitors|amod|END_ENTITY	Pharmacological evaluation of novel Alzheimer 's _ disease therapeutics : acetylcholinesterase inhibitors related to galanthamine .
20819637	0	galanthamine	35,47	tumor_necrosis_factor_alpha	63,90	galanthamine	tumor necrosis factor alpha	MESH:D005702	24835(Tax:10116)	Chemical	Gene	START_ENTITY|advcl|circulating circulating|dobj|END_ENTITY	Effect of cholinesterase inhibitor galanthamine on circulating tumor_necrosis_factor_alpha in rats with lipopolysaccharide-induced peritonitis .
6255718	0	galanthamine_hydrobromide	14,39	ACTH	50,54	galanthamine hydrobromide	ACTH	MESH:D005702	5443	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of galanthamine_hydrobromide on plasma ACTH in patients undergoing anaesthesia and surgery .
22613079	0	galanthamine_hydrobromide	123,148	acetylcholinesterase	43,63	galanthamine hydrobromide	acetylcholinesterase	MESH:D005702	83817(Tax:10116)	Chemical	Gene	administration|nmod|START_ENTITY brain|nmod|administration inhibition|nmod|brain inhibition|amod|END_ENTITY	Pharmacokinetic behavior and efficiency of acetylcholinesterase inhibition in rat brain after intranasal administration of galanthamine_hydrobromide loaded flexible liposomes .
21187459	0	galectins	76,85	VEGF-C	28,34	galectins	VEGF-C	null	7424	Chemical	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Differential stimulation of VEGF-C production by adhesion/growth-regulatory galectins and plant lectins in human breast_cancer cells .
25322914	0	gallic_acid	39,50	CYP3A4	29,35	gallic acid	CYP3A4	MESH:D005707	1576	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Time-dependent inhibition of CYP3A4 by gallic_acid in human liver microsomes and recombinant systems .
18930055	0	gallic_acid	22,33	UDP-glucose_dehydrogenase	51,76	gallic acid	UDP-glucose dehydrogenase	MESH:D005707	7358	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activity activity|amod|END_ENTITY	Inhibitory effects of gallic_acid and quercetin on UDP-glucose_dehydrogenase activity .
15081893	0	gallic_acid	40,51	fucosyltransferase_VII	14,36	gallic acid	fucosyltransferase VII	MESH:D005707	2529	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of fucosyltransferase_VII by gallic_acid and its derivatives .
10713556	0	gallic_acid_polydisulfide	10,35	catalase	65,73	gallic acid polydisulfide	catalase	null	847	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of gallic_acid_polydisulfide on activity and stability of catalase in various media .
24364476	0	gallinamide_A	37,50	cathepsin_L	96,107	gallinamide A	cathepsin L	MESH:C534687	1514	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	The marine cyanobacterial metabolite gallinamide_A is a potent and selective inhibitor of human cathepsin_L .
2253599	0	gallium	113,120	porphobilinogen_synthase	84,108	gallium	porphobilinogen synthase	MESH:D005708	25374(Tax:10116)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of liver , kidney , and erythrocyte delta-aminolevulinic_acid dehydratase -LRB- porphobilinogen_synthase -RRB- by gallium in the rat .
1517848	0	gallium-67	81,91	transferrin	57,68	gallium-67	transferrin	null	7018	Chemical	Gene	concentration|amod|START_ENTITY concentration|amod|END_ENTITY	Gallium-67 distribution in a man with a decrease in both transferrin and hepatic gallium-67 concentration .
1817816	2	gallopamil	57,67	insulin	80,87	gallopamil	insulin	MESH:D005711	3630	Chemical	Gene	infusion|amod|START_ENTITY infusion|nmod|END_ENTITY	Effects of gallopamil infusion on insulin and C peptide release in normal subjects .
11738606	0	gallotannin	97,108	tumor_necrosis_factor-alpha	47,74	gallotannin	tumor necrosis factor-alpha	CHEBI:24182	24835(Tax:10116)	Chemical	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	In vitro and in vivo inhibition of LPS-induced tumor_necrosis_factor-alpha production by dimeric gallotannin analogues .
11459638	0	gallotannin_beta-D-pentagalloylglucose	95,133	tumor_necrosis_factor-alpha	50,77	gallotannin beta-D-pentagalloylglucose	tumor necrosis factor-alpha	null	7124	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|inhibition inhibition|nmod|END_ENTITY	In vitro and In vivo inhibition of LPS-stimulated tumor_necrosis_factor-alpha secretion by the gallotannin_beta-D-pentagalloylglucose .
10733917	0	galloyl_esters	67,81	squalene_epoxidase	35,53	galloyl esters	squalene epoxidase	null	29230(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Potent and selective inhibition of squalene_epoxidase by synthetic galloyl_esters .
17828493	0	gambogic_acid	11,24	Nup88	58,63	gambogic acid	Nup88	MESH:C052659	4927	Chemical	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Effects of gambogic_acid on the regulation of nucleoporin Nup88 in U937 cells .
22783411	0	gambogic_acid	11,24	caspase-3	46,55	gambogic acid	caspase-3	MESH:C052659	836	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Effects of gambogic_acid on the activation of caspase-3 and downregulation of SIRT1 in RPMI-8226 multiple myeloma cells via the accumulation of ROS .
18226852	0	gambogic_acid	58,71	hTERT	49,54	gambogic acid	hTERT	MESH:C052659	7015	Chemical	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	Posttranscriptional regulation of the telomerase hTERT by gambogic_acid in human gastric_carcinoma 823 cells .
16257012	0	gambogic_acid	72,85	telomerase_reverse_transcriptase	20,52	gambogic acid	telomerase reverse transcriptase	MESH:C052659	7015	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Inhibition of human telomerase_reverse_transcriptase gene expression by gambogic_acid in human hepatoma SMMC-7721 cells .
8915826	0	gamma-Aminobutyric_acid	9,32	GAT-1	63,68	gamma-Aminobutyric acid	GAT-1	MESH:D005680	50676(Tax:10116)	Chemical	Gene	transporters|amod|START_ENTITY transporters|appos|END_ENTITY	Multiple gamma-Aminobutyric_acid plasma membrane transporters -LRB- GAT-1 , GAT-2 , GAT-3 -RRB- in the rat retina .
8915826	0	gamma-Aminobutyric_acid	9,32	GAT-2	70,75	gamma-Aminobutyric acid	GAT-2	MESH:D005680	171163(Tax:10116)	Chemical	Gene	transporters|amod|START_ENTITY transporters|appos|GAT-1 GAT-1|dep|END_ENTITY	Multiple gamma-Aminobutyric_acid plasma membrane transporters -LRB- GAT-1 , GAT-2 , GAT-3 -RRB- in the rat retina .
8915826	0	gamma-Aminobutyric_acid	9,32	GAT-3	77,82	gamma-Aminobutyric acid	GAT-3	MESH:D005680	79213(Tax:10116)	Chemical	Gene	transporters|amod|START_ENTITY transporters|appos|GAT-1 GAT-1|dep|END_ENTITY	Multiple gamma-Aminobutyric_acid plasma membrane transporters -LRB- GAT-1 , GAT-2 , GAT-3 -RRB- in the rat retina .
17729251	0	gamma-Aminobutyric_acid	0,23	RDL	164,167	gamma-Aminobutyric acid	RDL	MESH:D005680	39054(Tax:7227)	Chemical	Gene	signaling|nsubj|START_ENTITY signaling|parataxis|receptors receptors|nmod|END_ENTITY	gamma-Aminobutyric_acid -LRB- GABA -RRB- signaling components in Drosophila : immunocytochemical localization of GABA -LRB- B -RRB- receptors in relation to the GABA -LRB- A -RRB- receptor subunit RDL and a vesicular_GABA_transporter .
3991046	0	gamma-Aminobutyric_acid	0,23	prolactin	80,89	gamma-Aminobutyric acid	prolactin	MESH:D005680	24683(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|levels levels|nmod|END_ENTITY	gamma-Aminobutyric_acid decreases levels of messenger ribonucleic acid encoding prolactin in the rat pituitary .
1967972	0	gamma-Aminobutyric_acid	0,23	somatostatin	69,81	gamma-Aminobutyric acid	somatostatin	MESH:D005680	24797(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|nmod|END_ENTITY	gamma-Aminobutyric_acid inhibits the potassium-stimulated release of somatostatin from rat spinal cord slices .
11997080	0	gamma-Carboxyglutamic_acid	0,26	des-gamma-carboxy_prothrombin	74,103	gamma-Carboxyglutamic acid	des-gamma-carboxy prothrombin	MESH:D015055	1636	Chemical	Gene	content|amod|START_ENTITY content|nmod|END_ENTITY	gamma-Carboxyglutamic_acid content of hepatocellular_carcinoma-associated des-gamma-carboxy_prothrombin .
8637222	0	gamma-INF	17,26	TNF-alpha	6,15	gamma-INF	TNF-alpha	null	7124	Chemical	Gene	levels|amod|START_ENTITY END_ENTITY|appos|levels	Serum TNF-alpha , gamma-INF , G-CSF and GM-CSF levels in neutropenic children with acute_leukemia treated with short-course , high-dose methylprednisolone .
8921001	0	gamma-S-adenosyl-L-methionine	22,51	Interleukin-2	0,13	gamma-S-adenosyl-L-methionine	Interleukin-2	null	3558	Chemical	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Interleukin-2 induces gamma-S-adenosyl-L-methionine synthetase gene expression during T-lymphocyte activation .
2051176	0	gamma-acetylenic_GABA	123,144	GABA-transaminase	100,117	gamma-acetylenic GABA	GABA-transaminase	MESH:C013785	81632(Tax:10116)	Chemical	Gene	located|nmod|START_ENTITY located|nmod|inhibition inhibition|nmod|END_ENTITY	Immunocytochemical identification of GABA in astrocytes located in white matter after inhibition of GABA-transaminase with gamma-acetylenic_GABA .
6258106	0	gamma-acetylenic_GABA	37,58	GABA-transaminase	88,105	gamma-acetylenic GABA	GABA-transaminase	MESH:C013785	18	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|nmod|END_ENTITY	Treatment of Huntington_disease with gamma-acetylenic_GABA an irreversible inhibitor of GABA-transaminase : increased CSF GABA and homocarnosine without clinical amelioration .
6662342	0	gamma-acetylenic_GABA	53,74	GABA-transaminase	98,115	gamma-acetylenic GABA	GABA-transaminase	MESH:C013785	18	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Involvement of GABA in the antinociceptive effect of gamma-acetylenic_GABA -LRB- GAG -RRB- , an inhibitor of GABA-transaminase .
699960	0	gamma-acetylenic_GABA	14,35	GABA-transaminase	83,100	gamma-acetylenic GABA	GABA-transaminase	MESH:C013785	81632(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|inhibitor inhibitor|nmod|END_ENTITY	The effect of gamma-acetylenic_GABA , an enzyme-activated irreversible inhibitor of GABA-transaminase , on dopamine pathways of the extrapyramidal and limbic systems .
9772509	0	gamma-amino-butyric_acid	12,36	CA1	124,127	gamma-amino-butyric acid	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	currents|amod|START_ENTITY currents|nmod|neurons neurons|compound|END_ENTITY	-LSB- Changes in gamma-amino-butyric_acid and N-methyl-D-aspartic_acid receptor-gated currents from freshly isolated hippocampal CA1 pyramidal neurons of hepatic_encephalopathy rats -RSB- .
15685626	0	gamma-amino-butyric_acid	17,41	GABBR1	61,67	gamma-amino-butyric acid	GABBR1	MESH:D005680	2550	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Evidence for the gamma-amino-butyric_acid type B receptor 1 -LRB- GABBR1 -RRB- gene as a susceptibility factor in obsessive-compulsive_disorder .
19215359	0	gamma-aminobutyric_Acid	27,50	growth_hormone	88,102	gamma-aminobutyric Acid	growth hormone	MESH:D005680	81668(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY Activation|nmod|receptors resets|nsubj|Activation resets|dobj|pendulum pendulum|nmod|clock clock|amod|END_ENTITY	Activation of hypothalamic gamma-aminobutyric_Acid receptors resets the pendulum of the growth_hormone clock .
2331564	0	gamma-aminobutyric_acid	29,52	CA1	72,75	gamma-aminobutyric acid	CA1	MESH:D005680	310218(Tax:10116)	Chemical	Gene	blockers|amod|START_ENTITY blockers|nmod|END_ENTITY	The effect of two lipophilic gamma-aminobutyric_acid uptake blockers in CA1 of the rat hippocampal slice .
10984509	0	gamma-aminobutyric_acid	4,27	GABARAP	72,79	gamma-aminobutyric acid	GABARAP	MESH:D005680	11337	Chemical	Gene	type|amod|START_ENTITY type|appos|END_ENTITY	The gamma-aminobutyric_acid type A -LRB- GABAA -RRB- receptor-associated protein -LRB- GABARAP -RRB- promotes GABAA receptor clustering and modulates the channel kinetics .
21388957	0	gamma-aminobutyric_acid	56,79	GABARAP	126,133	gamma-aminobutyric acid	GABARAP	MESH:D005680	11337	Chemical	Gene	A|amod|START_ENTITY A|appos|END_ENTITY	Effects of C-terminal modifications of GEC1 protein and gamma-aminobutyric_acid type A -LRB- GABA -LRB- A -RRB- -RRB- receptor-associated protein -LRB- GABARAP -RRB- , two microtubule-associated proteins , on kappa_opioid_receptor expression .
15820424	0	gamma-aminobutyric_acid	33,56	GABBR1	76,82	gamma-aminobutyric acid	GABBR1	MESH:D005680	2550	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Possible association between the gamma-aminobutyric_acid type B receptor 1 -LRB- GABBR1 -RRB- gene and schizophrenia .
24136292	0	gamma-aminobutyric_acid	15,38	GABRA2	59,65	gamma-aminobutyric acid	GABRA2	MESH:D005680	2555	Chemical	Gene	gene|amod|START_ENTITY Association|nmod|gene Association|appos|END_ENTITY	Association of gamma-aminobutyric_acid A receptor a2 gene -LRB- GABRA2 -RRB- with alcohol_use_disorder .
12119096	0	gamma-aminobutyric_acid	10,33	GABRD	52,57	gamma-aminobutyric acid	GABRD	MESH:D005680	2563	Chemical	Gene	START_ENTITY|dep|gene gene|appos|END_ENTITY	The human gamma-aminobutyric_acid A receptor delta -LRB- GABRD -RRB- gene : molecular characterisation and tissue-specific expression .
7601451	0	gamma-aminobutyric_acid	4,27	GABRG3	59,65	gamma-aminobutyric acid	GABRG3	MESH:D005680	2567	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The gamma-aminobutyric_acid receptor gamma 3 subunit gene -LRB- GABRG3 -RRB- is tightly linked to the alpha 5 subunit gene -LRB- GABRA5 -RRB- on human chromosome 15q11-q13 and is transcribed in the same orientation .
10926932	0	gamma-aminobutyric_acid	60,83	GAT-1	27,32	gamma-aminobutyric acid	GAT-1	MESH:D005680	50676(Tax:10116)	Chemical	Gene	transporter|amod|START_ENTITY coupled|dobj|transporter Mutation|acl|coupled Mutation|nmod|arginine arginine|nmod|END_ENTITY	Mutation of arginine 44 of GAT-1 , a -LRB- Na -LRB- + -RRB- + Cl -LRB- - -RRB- -RRB- - coupled gamma-aminobutyric_acid transporter from rat brain , impairs net flux but not exchange .
11323124	0	gamma-aminobutyric_acid	24,47	GAT-1	61,66	gamma-aminobutyric acid	GAT-1	MESH:D005680	50676(Tax:10116)	Chemical	Gene	transporters|amod|START_ENTITY transporters|amod|END_ENTITY	Increased expression of gamma-aminobutyric_acid transporters GAT-1 and GAT-3 in the spinal trigeminal nucleus after facial carrageenan injections .
15789377	0	gamma-aminobutyric_acid	14,37	GAT-1	38,43	gamma-aminobutyric acid	GAT-1	MESH:D005680	232333(Tax:10090)	Chemical	Gene	transporters|amod|START_ENTITY transporters|compound|END_ENTITY	Activation of gamma-aminobutyric_acid GAT-1 transporters on glutamatergic terminals of mouse spinal cord mediates glutamate release through anion channels and by transporter reversal .
7962703	0	gamma-aminobutyric_acid	37,60	GAT-1	14,19	gamma-aminobutyric acid	GAT-1	MESH:D005680	50676(Tax:10116)	Chemical	Gene	plasma|amod|START_ENTITY END_ENTITY|appos|plasma	Expression of GAT-1 , a high-affinity gamma-aminobutyric_acid plasma membrane transporter in the rat retina .
8995422	0	gamma-aminobutyric_acid	54,77	GAT-1	25,30	gamma-aminobutyric acid	GAT-1	MESH:D005680	50676(Tax:10116)	Chemical	Gene	transporter|amod|START_ENTITY coupled|dobj|transporter topology|acl|coupled topology|nmod|END_ENTITY	The membrane topology of GAT-1 , a -LRB- Na + + Cl - -RRB- - coupled gamma-aminobutyric_acid transporter from rat brain .
9169433	0	gamma-aminobutyric_acid	74,97	GAT-1	68,73	gamma-aminobutyric acid	GAT-1	MESH:D005680	446294(Tax:8355)	Chemical	Gene	transporter|amod|START_ENTITY transporter|compound|END_ENTITY	Analysis of the transmembrane topology and membrane assembly of the GAT-1 gamma-aminobutyric_acid transporter .
9623887	0	gamma-aminobutyric_acid	58,81	GAT-1	35,40	gamma-aminobutyric acid	GAT-1	MESH:D005680	6529	Chemical	Gene	transporter|amod|START_ENTITY END_ENTITY|appos|transporter	Neuronal and glial localization of GAT-1 , a high-affinity gamma-aminobutyric_acid plasma membrane transporter , in human cerebral cortex : with a note on its distribution in monkey cortex .
9838150	0	gamma-aminobutyric_acid	28,51	GAT-1	143,148	gamma-aminobutyric acid	GAT-1	MESH:D005680	50676(Tax:10116)	Chemical	Gene	transporters|amod|START_ENTITY expression|nmod|transporters expression|dep|evidence evidence|nmod|presence presence|nmod|END_ENTITY	Developmental expression of gamma-aminobutyric_acid transporters -LRB- GAT-1 and GAT-3 -RRB- in the rat cerebellum : evidence for a transient presence of GAT-1 in Purkinje cells .
9838150	0	gamma-aminobutyric_acid	28,51	GAT-1	66,71	gamma-aminobutyric acid	GAT-1	MESH:D005680	50676(Tax:10116)	Chemical	Gene	transporters|amod|START_ENTITY transporters|dep|END_ENTITY	Developmental expression of gamma-aminobutyric_acid transporters -LRB- GAT-1 and GAT-3 -RRB- in the rat cerebellum : evidence for a transient presence of GAT-1 in Purkinje cells .
17502375	0	gamma-aminobutyric_acid	51,74	GAT-2	101,106	gamma-aminobutyric acid	GAT-2	MESH:D005680	6539	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Cloning and characterization of a functional human gamma-aminobutyric_acid -LRB- GABA -RRB- transporter , human GAT-2 .
9748227	0	gamma-aminobutyric_acid	82,105	GAT-2	119,124	gamma-aminobutyric acid	GAT-2	MESH:D005680	6539	Chemical	Gene	transporters|amod|START_ENTITY transporters|amod|END_ENTITY	Identification of sorting determinants in the C-terminal cytoplasmic tails of the gamma-aminobutyric_acid transporters GAT-2 and GAT-3 .
9818985	0	gamma-aminobutyric_acid	25,48	GH	72,74	gamma-aminobutyric acid	GH	MESH:D005680	2688	Chemical	Gene	control|amod|START_ENTITY control|nmod|secretion secretion|compound|END_ENTITY	Alcoholism abolishes the gamma-aminobutyric_acid -LRB- GABA -RRB- ergic control of GH secretion in humans .
6717243	0	gamma-aminobutyric_acid	74,97	Growth_hormone	0,14	gamma-aminobutyric acid	Growth hormone	MESH:D005680	81668(Tax:10116)	Chemical	Gene	stimulated|nmod|START_ENTITY stimulated|nsubjpass|secretion secretion|amod|END_ENTITY	Growth_hormone secretion of the neonatal rat pituitaries is stimulated by gamma-aminobutyric_acid in vitro .
872825	0	gamma-aminobutyric_acid	26,49	Growth_hormone	0,14	gamma-aminobutyric acid	Growth hormone	MESH:D005680	81668(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|END_ENTITY	Growth_hormone release by gamma-aminobutyric_acid -LRB- GABA -RRB- and gamma-amino-beta-hydroxybutyric_acid -LRB- GABOB -RRB- in the rat .
16462600	0	gamma-aminobutyric_acid	68,91	Mesencephalic_astrocyte-derived_neurotrophic_factor	0,51	gamma-aminobutyric acid	Mesencephalic astrocyte-derived neurotrophic factor	MESH:D005680	7873	Chemical	Gene	release|amod|START_ENTITY enhances|dobj|release enhances|nsubj|END_ENTITY	Mesencephalic_astrocyte-derived_neurotrophic_factor enhances nigral gamma-aminobutyric_acid release .
4045339	0	gamma-aminobutyric_acid	85,108	Prolactin	0,9	gamma-aminobutyric acid	Prolactin	MESH:D005680	24683(Tax:10116)	Chemical	Gene	synthesis|nmod|START_ENTITY increases|dobj|synthesis increases|nsubj|END_ENTITY	Prolactin in cerebrospinal fluid increases the synthesis and release of hypothalamic gamma-aminobutyric_acid .
6485704	0	gamma-aminobutyric_acid	95,118	Prolactin	0,9	gamma-aminobutyric acid	Prolactin	MESH:D005680	396453(Tax:9031)	Chemical	Gene	stimulation|nmod|START_ENTITY secretion|dep|stimulation secretion|compound|END_ENTITY	Prolactin and growth_hormone secretion in chickens : stimulation by histamine and inhibition by gamma-aminobutyric_acid .
21510217	0	gamma-aminobutyric_acid	29,52	RDL	25,28	gamma-aminobutyric acid	RDL	MESH:D005680	39054(Tax:7227)	Chemical	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	The A2 'N mutation of the RDL gamma-aminobutyric_acid receptor conferring fipronil resistance in Laodelphax_striatellus -LRB- Hemiptera : Delphacidae -RRB- .
3033417	0	gamma-aminobutyric_acid	65,88	alpha-MSH	92,101	gamma-aminobutyric acid	alpha-MSH	MESH:D005680	5443	Chemical	Gene	START_ENTITY|nmod|release release|amod|END_ENTITY	The benzodiazepine agonist clonazepam potentiates the effects of gamma-aminobutyric_acid on alpha-MSH release from neurointermediate lobes in vitro .
14984429	0	gamma-aminobutyric_acid	6,29	corticotropin-releasing_factor	81,111	gamma-aminobutyric acid	corticotropin-releasing factor	MESH:D005680	1392	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Local gamma-aminobutyric_acid and glutamate circuit control of hypophyseotrophic corticotropin-releasing_factor neuron activity in the paraventricular nucleus of the hypothalamus .
15611993	0	gamma-aminobutyric_acid	39,62	corticotropin-releasing_factor	91,121	gamma-aminobutyric acid	corticotropin-releasing factor	MESH:D005680	81648(Tax:10116)	Chemical	Gene	START_ENTITY|advcl|mediating mediating|dobj|effects effects|nmod|END_ENTITY	Ultrastructural evidence for a role of gamma-aminobutyric_acid in mediating the effects of corticotropin-releasing_factor on the rat dorsal raphe serotonin system .
6803541	0	gamma-aminobutyric_acid	122,145	diamine_oxidase	15,30	gamma-aminobutyric acid	diamine oxidase	MESH:D005680	76507(Tax:10090)	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of diamine_oxidase in catabolism of 14C-putrescine in mice in vivo with special reference to the formation of gamma-aminobutyric_acid .
10779376	0	gamma-aminobutyric_acid	84,107	gamma2	62,68	gamma-aminobutyric acid	gamma2	MESH:D005680	7453	Chemical	Gene	receptor|amod|START_ENTITY subunit|nmod|receptor subunit|amod|END_ENTITY	Identification of benzodiazepine binding site residues in the gamma2 subunit of the gamma-aminobutyric_acid -LRB- A -RRB- receptor .
10820157	0	gamma-aminobutyric_acid	86,109	gastrin	126,133	gamma-aminobutyric acid	gastrin	MESH:D005680	25320(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Immunocytochemical evidence suggesting that diamine_oxidase catalyzes biosynthesis of gamma-aminobutyric_acid in antropyloric gastrin cells .
12774663	0	gamma-aminobutyric_acid	18,41	glutamate_decarboxylase	72,95	gamma-aminobutyric acid	glutamate decarboxylase	MESH:D005680	2752	Chemical	Gene	concentration|amod|START_ENTITY concentration|nmod|END_ENTITY	-LSB- Determination of gamma-aminobutyric_acid concentration and activity of glutamate_decarboxylase in blood serum of patients with multiple_sclerosis -RSB- .
6387051	0	gamma-aminobutyric_acid	63,86	glutamate_decarboxylase	36,59	gamma-aminobutyric acid	glutamate decarboxylase	MESH:D005680	2752	Chemical	Gene	Evidence|nmod|START_ENTITY Evidence|nmod|END_ENTITY	Evidence for feedback regulation of glutamate_decarboxylase by gamma-aminobutyric_acid .
1625515	0	gamma-aminobutyric_acid	15,38	growth_hormone	81,95	gamma-aminobutyric acid	growth hormone	MESH:D005680	2688	Chemical	Gene	derivative|amod|START_ENTITY Failure|nmod|derivative baclofen|nsubj|Failure baclofen|xcomp|stimulate stimulate|dobj|secretion secretion|amod|END_ENTITY	Failure of the gamma-aminobutyric_acid -LRB- GABA -RRB- derivative , baclofen , to stimulate growth_hormone secretion in heroin addicts .
1772578	0	gamma-aminobutyric_acid	15,38	growth_hormone	81,95	gamma-aminobutyric acid	growth hormone	MESH:D005680	2688	Chemical	Gene	derivative|amod|START_ENTITY Failure|nmod|derivative baclofen|nsubj|Failure baclofen|xcomp|stimulate stimulate|dobj|secretion secretion|amod|END_ENTITY	Failure of the gamma-aminobutyric_acid -LRB- GABA -RRB- derivative , baclofen , to stimulate growth_hormone secretion in Parkinson 's _ disease .
3003218	0	gamma-aminobutyric_acid	11,34	growth_hormone	73,87	gamma-aminobutyric acid	growth hormone	MESH:D005680	81668(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY Effects|nmod|receptor agonists|nsubj|Effects agonists|nmod|secretion secretion|nmod|END_ENTITY	Effects of gamma-aminobutyric_acid receptor agonists on the secretion of growth_hormone , luteinizing hormone , adrenocorticotrophic hormone and thyroid-stimulating hormone from the rat pituitary gland in vitro .
6151130	0	gamma-aminobutyric_acid	8,31	growth_hormone	62,76	gamma-aminobutyric acid	growth hormone	MESH:D005680	81668(Tax:10116)	Chemical	Gene	Site|nmod|START_ENTITY Site|dep|inhibition inhibition|nmod|secretion secretion|amod|END_ENTITY	Site of gamma-aminobutyric_acid -LRB- GABA -RRB- - mediated inhibition of growth_hormone secretion in the rat .
7349964	0	gamma-aminobutyric_acid	103,126	growth_hormone	31,45	gamma-aminobutyric acid	growth hormone	MESH:D005680	81668(Tax:10116)	Chemical	Gene	injection|acl|START_ENTITY increases|nmod|injection increases|nmod|END_ENTITY	Concomitant increases in serum growth_hormone and hypothalamic somatostatin in rats after injection of gamma-aminobutyric_acid , aminooxyacetic_acid , or gamma-hydroxybutyric_acid .
8388979	0	gamma-aminobutyric_acid	51,74	growth_hormone	83,97	gamma-aminobutyric acid	growth hormone	MESH:D005680	81668(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY secretion|compound|END_ENTITY	Significance of chloride channel activation in the gamma-aminobutyric_acid induced growth_hormone secretion in the neonatal rat pituitary .
3926462	0	gamma-aminobutyric_acid	86,109	growth_hormone-releasing_factor	15,46	gamma-aminobutyric acid	growth hormone-releasing factor	MESH:D005680	29446(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of growth_hormone-releasing_factor in growth hormone secretion induced by gamma-aminobutyric_acid in conscious rats .
12422272	0	gamma-aminobutyric_acid	73,96	mGAT3	110,115	gamma-aminobutyric acid	mGAT3	MESH:D005680	14412(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|transporter transporter|appos|END_ENTITY	Presteady-state and steady-state kinetics and turnover rate of the mouse gamma-aminobutyric_acid transporter -LRB- mGAT3 -RRB- .
3567460	0	gamma-aminobutyric_acid	11,34	neurotensin	56,67	gamma-aminobutyric acid	neurotensin	MESH:D005680	100727527	Chemical	Gene	Release|nmod|START_ENTITY Release|nmod|END_ENTITY	Release of gamma-aminobutyric_acid and acetylcholine by neurotensin in guinea-pig ileum .
10221597	0	gamma-aminobutyric_acid	19,42	prolactin	140,149	gamma-aminobutyric acid	prolactin	MESH:D005680	443317(Tax:9940)	Chemical	Gene	agonists|amod|START_ENTITY infusing|dobj|agonists Effect|acl|infusing Effect|nmod|END_ENTITY	Effect of infusing gamma-aminobutyric_acid receptor agonists and antagonists into the medial preoptic area and ventromedial hypothalamus on prolactin secretion in male sheep .
14724063	0	gamma-aminobutyric_acid	165,188	prolactin	11,20	gamma-aminobutyric acid	prolactin	MESH:D005680	24683(Tax:10116)	Chemical	Gene	taurine|amod|START_ENTITY dopamine|dep|taurine Changes|nmod|dopamine Changes|nmod|mechanisms mechanisms|amod|END_ENTITY	Changes of prolactin regulatory mechanisms in aging : 24-h rhythms of serum prolactin and median eminence and adenohypophysial concentration of dopamine , serotonin , -LRB- gamma-aminobutyric_acid , taurine and somatostatin in young and aged rats .
162520	0	gamma-aminobutyric_acid	69,92	prolactin	15,24	gamma-aminobutyric acid	prolactin	MESH:D005680	5617	Chemical	Gene	agonist|amod|START_ENTITY muscimol|appos|agonist secretion|nmod|muscimol secretion|nsubj|Stimulation Stimulation|nmod|END_ENTITY	Stimulation of prolactin and growth_hormone secretion by muscimol , a gamma-aminobutyric_acid agonist .
3019475	0	gamma-aminobutyric_acid	32,55	prolactin	70,79	gamma-aminobutyric acid	prolactin	MESH:D005680	24683(Tax:10116)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|secretion secretion|compound|END_ENTITY	The arcuate nucleus : a site for gamma-aminobutyric_acid regulation of prolactin secretion .
407071	0	gamma-aminobutyric_acid	11,34	prolactin	52,61	gamma-aminobutyric acid	prolactin	MESH:D005680	24683(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of gamma-aminobutyric_acid and histamine on prolactin secretion in the rat .
9825732	0	gamma-aminobutyric_acid	105,128	prolactin	27,36	gamma-aminobutyric acid	prolactin	MESH:D005680	24683(Tax:10116)	Chemical	Gene	inputs|amod|START_ENTITY changes|nmod|inputs involvement|nmod|changes Effects|dep|involvement Effects|nmod|cannabinoids cannabinoids|nmod|secretion secretion|compound|END_ENTITY	Effects of cannabinoids on prolactin and gonadotrophin secretion : involvement of changes in hypothalamic gamma-aminobutyric_acid -LRB- GABA -RRB- inputs .
2564210	0	gamma-aminobutyric_acid	10,33	somatostatin	64,76	gamma-aminobutyric acid	somatostatin	MESH:D005680	24797(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of gamma-aminobutyric_acid on bombesin-evoked release of somatostatin and gastrin from isolated rat stomach .
6129132	0	gamma-aminobutyric_acid	141,164	somatostatin	38,50	gamma-aminobutyric acid	somatostatin	MESH:D005680	24797(Tax:10116)	Chemical	Gene	dispersed|nmod|START_ENTITY dispersed|nsubj|stimulation stimulation|nmod|secretion secretion|compound|END_ENTITY	Muscarinic cholinergic stimulation of somatostatin secretion from long term dispersed cell cultures of fetal rat hypothalamus : inhibition by gamma-aminobutyric_acid and serotonin .
23428122	0	gamma-aminobutyric_acid	11,34	substance_P	55,66	gamma-aminobutyric acid	substance P	MESH:D005680	6863	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|END_ENTITY	-LSB- Effect of gamma-aminobutyric_acid treatment on plasma substance_P and calcitonin_gene-related_peptide levels in children with asthma -RSB- .
8700112	0	gamma-aminobutyric_acidA	51,75	beta_1	35,41	gamma-aminobutyric acidA	beta 1	null	15129(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Enhancement of recombinant alpha 1 beta_1 gamma 2L gamma-aminobutyric_acidA receptor whole-cell currents by protein_kinase_C is mediated through phosphorylation of both beta_1 and gamma 2L subunits .
15174080	0	gamma-aminobutyric_acidergic	106,134	CRF-R1	56,62	gamma-aminobutyric acidergic	CRF-R1	null	58959(Tax:10116)	Chemical	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	Differential expression of 5HT-1A , alpha 1b adrenergic , CRF-R1 , and CRF-R2 receptor mRNA in serotonergic , gamma-aminobutyric_acidergic , and catecholaminergic cells of the rat dorsal raphe nucleus .
11341846	0	gamma-boroGlu	60,73	gamma-glutamyl_transpeptidase	27,56	gamma-boroGlu	gamma-glutamyl transpeptidase	null	92086	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Slow-binding inhibition of gamma-glutamyl_transpeptidase by gamma-boroGlu .
9370109	0	gamma-butyric_acid	11,29	thyrotropin-releasing_hormone	48,77	gamma-butyric acid	thyrotropin-releasing hormone	null	25569(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	Effects of gamma-butyric_acid on the release of thyrotropin-releasing_hormone from the rat retina in vitro .
8216249	4	gamma-carboxyglutamic_acid	626,652	amino_acids	678,689	gamma-carboxyglutamic acid	prothrombin	MESH:D015055	2147	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Edman degradation revealed 81.8 % sequence identity of the 11 N-terminal amino_acids of CMP with the N-terminus of human prothrombin , which contains 10 gamma-carboxyglutamic_acid residues in the first 32 amino_acids .
2198285	0	gamma-carboxyglutamic_acid	98,124	coagulation_factor_IX	135,156	gamma-carboxyglutamic acid	coagulation factor IX	MESH:D015055	2158	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	In vitro gamma-carboxylation of a 59-residue recombinant peptide including the propeptide and the gamma-carboxyglutamic_acid domain of coagulation_factor_IX .
9047312	0	gamma-carboxyglutamic_acid	48,74	coagulation_factor_IX	85,106	gamma-carboxyglutamic acid	coagulation factor IX	MESH:D015055	280688(Tax:9913)	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Refinement of the NMR solution structure of the gamma-carboxyglutamic_acid domain of coagulation_factor_IX using molecular dynamics simulation with initial Ca2 + positions determined by a genetic algorithm .
16156662	0	gamma-carboxyglutamic_acid	46,72	protein_C	83,92	gamma-carboxyglutamic acid	protein C	MESH:D015055	5624	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Role of the hexapeptide_disulfide loop in the gamma-carboxyglutamic_acid domain of protein_C in Ca2 + - mediated structural and functional properties .
1905953	0	gamma-carboxyglutamic_acid	54,80	protein_C	97,106	gamma-carboxyglutamic acid	protein C	MESH:D015055	5624	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Role of the hexapeptide disulfide loop present in the gamma-carboxyglutamic_acid domain of human protein_C in its activation properties and in the in vitro anticoagulant activity of activated protein_C .
9078278	0	gamma-carboxyglutamic_acid	90,116	protein_C	149,158	gamma-carboxyglutamic acid	protein C	MESH:D015055	5624	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Highly conserved residue arginine-15 is required for the Ca2 + - dependent properties of the gamma-carboxyglutamic_acid domain of human anticoagulation protein_C and activated protein_C .
11530932	0	gamma-glutamyl	9,23	Mpv17	79,84	gamma-glutamyl	Mpv17	CHEBI:24190	17527(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Enhanced gamma-glutamyl transpeptidase expression and superoxide production in Mpv17 - / - glomerulosclerosis mice .
17129343	0	gamma-glutamyl	51,65	tissue_transglutaminase	14,37	gamma-glutamyl	tissue transglutaminase	CHEBI:24190	7052	Chemical	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of tissue_transglutaminase and epsilon -LRB- gamma-glutamyl -RRB- lysine cross-linking in human hypertrophic_scar .
5452395	0	gamma-guanidinobutyramide	14,39	insulin	74,81	gamma-guanidinobutyramide	insulin	MESH:C001316	3630	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|nmod|END_ENTITY	The effect of gamma-guanidinobutyramide on the secretion and synthesis of insulin in vitro .
1380685	0	gamma-hexachlorocyclohexane	10,37	proto-oncogene_c-fos	57,77	gamma-hexachlorocyclohexane	proto-oncogene c-fos	MESH:D001556	314322(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of gamma-hexachlorocyclohexane and its isomers on proto-oncogene_c-fos expression in brain .
16001124	0	gamma-hydroxybutyrate	35,56	GBL	113,116	gamma-hydroxybutyrate	GBL	MESH:D012978	64226(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Discriminative stimulus effects of gamma-hydroxybutyrate -LRB- GHB -RRB- and its metabolic precursor , gamma-butyrolactone -LRB- GBL -RRB- in rats .
7814832	0	gamma-hydroxybutyric_acid	49,74	growth_hormone	22,36	gamma-hydroxybutyric acid	growth hormone	MESH:C111420	2688	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|response response|amod|END_ENTITY	Flumazenil effects on growth_hormone response to gamma-hydroxybutyric_acid .
17502341	0	gamma-hydroxybutyric_acid	68,93	monocarboxylate_transporter_2_and_4	12,47	gamma-hydroxybutyric acid	monocarboxylate transporter 2 and 4	MESH:C111420	9122	Chemical	Gene	transport|nmod|START_ENTITY role|nmod|transport role|nmod|END_ENTITY	The role of monocarboxylate_transporter_2_and_4 in the transport of gamma-hydroxybutyric_acid in mammalian cells .
18039575	0	gamma-lactam	30,42	EP2	65,68	gamma-lactam	EP2	CHEBI:74222	5732	Chemical	Gene	Synthesis|nmod|START_ENTITY Synthesis|nmod|END_ENTITY	Synthesis and evaluation of a gamma-lactam as a highly selective EP2 and EP4 receptor agonist .
12408705	0	gamma-lactam_hydroxamic_acids	13,42	tumor_necrosis_factor_alpha_converting_enzyme	70,115	gamma-lactam hydroxamic acids	tumor necrosis factor alpha converting enzyme	null	6868	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Discovery of gamma-lactam_hydroxamic_acids as selective inhibitors of tumor_necrosis_factor_alpha_converting_enzyme : design , synthesis , and structure-activity relationships .
15850718	0	gamma-linolenic_acid	31,51	15-lipoxygenase	0,15	gamma-linolenic acid	15-lipoxygenase	MESH:D017965	246	Chemical	Gene	metabolites|nmod|START_ENTITY metabolites|amod|END_ENTITY	15-lipoxygenase metabolites of gamma-linolenic_acid / eicosapentaenoic_acid suppress growth and arachidonic_acid metabolism in human prostatic_adenocarcinoma cells : possible implications of dietary fatty_acids .
1650000	0	gamma-linolenic_acid	76,96	delta-6-desaturase	24,42	gamma-linolenic acid	delta-6-desaturase	MESH:D017965	56473(Tax:10090)	Chemical	Gene	involvement|nmod|START_ENTITY involvement|nmod|END_ENTITY	Possible involvement of delta-6-desaturase in control of melanoma growth by gamma-linolenic_acid .
9242500	0	gamma-linolenic_and_other_fatty_acid	69,105	5alpha-reductase	120,136	gamma-linolenic and other fatty acid	5alpha-reductase	null	6715	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Growth suppression of hamster flank organs by topical application of gamma-linolenic_and_other_fatty_acid inhibitors of 5alpha-reductase .
9765269	0	gamma-phosphate	28,43	myosin	60,66	gamma-phosphate	myosin	null	79784	Chemical	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Effects of mutations in the gamma-phosphate binding site of myosin on its motor function .
10073977	0	gamma-tocotrienol	11,28	ApoB	32,36	gamma-tocotrienol	ApoB	MESH:C013649	338	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|synthesis synthesis|compound|END_ENTITY	Effects of gamma-tocotrienol on ApoB synthesis , degradation , and secretion in HepG2 cells .
8336820	0	gamma-vinylGABA	56,71	GABA_transaminase	27,44	gamma-vinylGABA	GABA transaminase	MESH:D020888	81632(Tax:10116)	Chemical	Gene	inhibitors|dobj|START_ENTITY inhibitors|nsubj|effects effects|nmod|END_ENTITY	Contrasting effects of the GABA_transaminase inhibitors gamma-vinylGABA and aminooxyacetic_acid on arterial pressure following injection into nucleus tractus solitarius .
923642	0	gamma-vinyl_GABA	113,129	GABA-T	148,154	gamma-vinyl GABA	GABA-T	MESH:D020888	268860(Tax:10090)	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|amod|END_ENTITY	Audiogenic seizure protection by elevated brain GABA concentration in mice : effects of gamma-acetylenic gaba and gamma-vinyl_GABA , two irreversible GABA-T inhibitors .
3092125	0	gamma-vinyl_GABA	23,39	GABA-transaminase	57,74	gamma-vinyl GABA	GABA-transaminase	MESH:D020888	18	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Differential effect of gamma-vinyl_GABA and valproate on GABA-transaminase from cultured neurones and astrocytes .
3683730	0	gamma-vinyl_GABA	59,75	GABA-transaminase	30,47	gamma-vinyl GABA	GABA-transaminase	MESH:D020888	18	Chemical	Gene	inhibitors|dobj|START_ENTITY inhibitors|nsubj|uptake uptake|nmod|END_ENTITY	Stereoselective uptake of the GABA-transaminase inhibitors gamma-vinyl_GABA and gamma-acetylenic_GABA into neurons and astrocytes .
4041811	0	gamma-vinyl_GABA	118,134	GABA-transaminase	89,106	gamma-vinyl GABA	GABA-transaminase	MESH:D020888	81632(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Iron concentration reduced in ventral pallidum , globus pallidus , and substantia nigra by GABA-transaminase inhibitor , gamma-vinyl_GABA .
7886090	0	gamma-vinyl_GABA	70,86	GABA-transaminase	30,47	gamma-vinyl GABA	GABA-transaminase	MESH:D020888	81632(Tax:10116)	Chemical	Gene	effect|appos|START_ENTITY effect|nmod|vigabatrin vigabatrin|amod|END_ENTITY	Anxiolytic-like effect of the GABA-transaminase inhibitor vigabatrin -LRB- gamma-vinyl_GABA -RRB- on rat exploratory activity .
21552497	4	gammaD-crystallin	661,678	CRYGD	680,685	gammaD-crystallin	CRYAA	null	1409	Chemical	Gene	_|amod|START_ENTITY _|appos|END_ENTITY	Mutation analysis was performed by direct sequencing of the candidate genes : gammaC-crystallin -LRB- CRYGC -RRB- , gammaD-crystallin _ -LRB- CRYGD -RRB- , gammaS-crystallin -LRB- CRYGS -RRB- , gap-junction_protein , _ alpha_8 -LRB- GJA8 -RRB- , gap-junction_protein , _ alpha_3 -LRB- GJA3 -RRB- , and alphaA-crystallin -LRB- CRYAA -RRB- .
15041665	0	gammaM4	46,53	muscle_nicotinic_acetylcholine_receptor	82,121	gammaM4	muscle nicotinic acetylcholine receptor	null	1134	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Cholesterol modulates the organization of the gammaM4 transmembrane domain of the muscle_nicotinic_acetylcholine_receptor .
10780877	0	gamma_linolenic_acid	85,105	Peroxisome_proliferator_activated_receptor-gamma	0,48	gamma linolenic acid	Peroxisome proliferator activated receptor-gamma	MESH:D017965	5468	Chemical	Gene	action|nmod|START_ENTITY mediates|dobj|action mediates|nsubj|END_ENTITY	Peroxisome_proliferator_activated_receptor-gamma -LRB- PPAR-gamma -RRB- mediates the action of gamma_linolenic_acid in breast_cancer cells .
14596595	0	gamma_phosphate	51,66	Sky1p	105,110	gamma phosphate	Sky1p	null	855256(Tax:4932)	Chemical	Gene	binding|nmod|START_ENTITY binding|nmod|END_ENTITY	Novel destabilization of nucleotide binding by the gamma_phosphate of ATP in the yeast SR protein kinase Sky1p .
9413023	0	gammahydroxy_butyric_acid	11,36	growth_hormone	50,64	gammahydroxy butyric acid	growth hormone	MESH:C111420	2688	Chemical	Gene	START_ENTITY|xcomp|stimulate stimulate|dobj|secretion secretion|amod|END_ENTITY	Failure of gammahydroxy_butyric_acid to stimulate growth_hormone secretion in cocaine addicts .
10824137	0	ganciclovir	31,42	PEPT1	77,82	ganciclovir	PEPT1	MESH:D015774	6564	Chemical	Gene	Transport|appos|START_ENTITY Transport|nmod|END_ENTITY	Transport of valganciclovir , a ganciclovir prodrug , via peptide transporters PEPT1 and PEPT2 .
20385869	0	ganciclovir	77,88	UL97	43,47	ganciclovir	UL97	MESH:D015774	3077517(Tax:10359)	Chemical	Gene	resistance|compound|START_ENTITY END_ENTITY|nmod|resistance	Recombinant phenotyping of cytomegalovirus UL97 kinase sequence variants for ganciclovir resistance .
8145779	0	ganciclovir	56,67	UL97	102,106	ganciclovir	UL97	MESH:D015774	3077517(Tax:10359)	Chemical	Gene	START_ENTITY|nmod|mutations mutations|nmod|END_ENTITY	Rapid detection of cytomegalovirus strains resistant to ganciclovir through mutations within the gene UL97 .
23212626	0	ganetespib	37,47	Hsp90	53,58	ganetespib	Hsp90	MESH:C533237	3320	Chemical	Gene	development|nmod|START_ENTITY updates|nmod|development updates|nmod|inhibitor inhibitor|amod|END_ENTITY	Recent updates on the development of ganetespib as a Hsp90 inhibitor .
23303741	0	ganetespib	29,39	Hsp90	44,49	ganetespib	Hsp90	MESH:C533237	3320	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Initial testing -LRB- stage 1 -RRB- of ganetespib , an Hsp90 inhibitor , by the Pediatric Preclinical Testing Program .
24398428	0	ganetespib	96,106	Hsp90	85,90	ganetespib	Hsp90	MESH:C533237	3320	Chemical	Gene	acquired|nmod|START_ENTITY acquired|nmod|melanoma melanoma|nmod|inhibition inhibition|nmod|END_ENTITY	Overcoming acquired BRAF inhibitor resistance in melanoma via targeted inhibition of Hsp90 with ganetespib .
26581400	0	ganetespib	20,30	Hsp90	56,61	ganetespib	Hsp90	MESH:C533237	3320	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	A phase II trial of ganetespib , a heat_shock_protein_90 Hsp90 -RRB- inhibitor , in patients with docetaxel-pretreated metastatic castrate-resistant prostate_cancer -LRB- CRPC -RRB- - a prostate_cancer clinical trials consortium -LRB- PCCTC -RRB- study .
26581400	0	ganetespib	20,30	heat_shock_protein_90	34,55	ganetespib	heat shock protein 90	MESH:C533237	3320	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	A phase II trial of ganetespib , a heat_shock_protein_90 Hsp90 -RRB- inhibitor , in patients with docetaxel-pretreated metastatic castrate-resistant prostate_cancer -LRB- CRPC -RRB- - a prostate_cancer clinical trials consortium -LRB- PCCTC -RRB- study .
9682003	0	ganglioside	46,57	CD4	23,26	ganglioside	CD4	CHEBI:28892	920	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	The down-modulation of CD4 induced by the GM1 ganglioside is regulated by phosphatases and kinases : evidence from enzyme inhibitors and anti-CD45 antibodies .
11447130	0	ganglioside	63,74	Epidermal_growth_factor_receptor	0,32	ganglioside	Epidermal growth factor receptor	CHEBI:28892	1956	Chemical	Gene	correction|amod|START_ENTITY required|nmod|correction required|nsubjpass|glycosylation glycosylation|compound|END_ENTITY	Epidermal_growth_factor_receptor glycosylation is required for ganglioside GM3 binding and GM3-mediated suppression -LSB- correction of suppresion -RSB- of activation .
10397254	0	ganglioside	4,15	GD3	0,3	ganglioside	GD3	CHEBI:28892	117189	Chemical	Gene	antibody|amod|START_ENTITY antibody|nummod|END_ENTITY	GD3 ganglioside antibody augments tumoricidal capacity of canine blood mononuclear cells by induction of interleukin 12 .
15269144	0	ganglioside	129,140	GD3	50,53	ganglioside	GD3	CHEBI:28892	117189	Chemical	Gene	mimics|xcomp|START_ENTITY antibody|acl:relcl|mimics ganglioside|dobj|antibody ganglioside|nsubj|immunization immunization|nmod|patients patients|nmod|END_ENTITY	Sequential immunization of melanoma patients with GD3 ganglioside vaccine and anti-idiotypic monoclonal antibody that mimics GD3 ganglioside .
15269144	0	ganglioside	54,65	GD3	125,128	ganglioside	GD3	CHEBI:28892	117189	Chemical	Gene	START_ENTITY|dobj|antibody antibody|acl:relcl|mimics mimics|xcomp|ganglioside ganglioside|nsubj|END_ENTITY	Sequential immunization of melanoma patients with GD3 ganglioside vaccine and anti-idiotypic monoclonal antibody that mimics GD3 ganglioside .
15269144	0	ganglioside	54,65	GD3	50,53	ganglioside	GD3	CHEBI:28892	117189	Chemical	Gene	START_ENTITY|nsubj|immunization immunization|nmod|patients patients|nmod|END_ENTITY	Sequential immunization of melanoma patients with GD3 ganglioside vaccine and anti-idiotypic monoclonal antibody that mimics GD3 ganglioside .
16441517	0	ganglioside	15,26	GD3	11,14	ganglioside	GD3	CHEBI:28892	117189	Chemical	Gene	induces|advmod|START_ENTITY induces|nsubj|END_ENTITY	Endogenous GD3 ganglioside induces apoptosis in U-1242 MG_glioma cells .
1695649	0	ganglioside	62,73	GD3	58,61	ganglioside	GD3	CHEBI:28892	117189	Chemical	Gene	START_ENTITY|nsubj|binding binding|nmod|antibodies antibodies|nmod|END_ENTITY	Homophilic binding of mouse monoclonal antibodies against GD3 ganglioside .
17242043	0	ganglioside	76,87	GD3	72,75	ganglioside	GD3	CHEBI:28892	117189	Chemical	Gene	START_ENTITY|nsubj|characterization characterization|nmod|form form|nmod|END_ENTITY	Purification and structural characterization of de-N-acetylated form of GD3 ganglioside present in human melanoma_tumors .
3292545	0	ganglioside	17,28	GD3	13,16	ganglioside	GD3	CHEBI:28892	117189	Chemical	Gene	START_ENTITY|nsubj|Detection Detection|nmod|END_ENTITY	Detection of GD3 ganglioside in childhood acute_lymphoblastic_leukemia with monoclonal antibody to GD3 : restriction to immunophenotypically defined T-cell disease .
6488184	0	ganglioside	27,38	GD3	39,42	ganglioside	GD3	CHEBI:28892	117189	Chemical	Gene	expression|nmod|START_ENTITY END_ENTITY|nsubj|expression	Differential expression of ganglioside GD3 by human leukocytes and leukemia cells .
7881823	0	ganglioside	29,40	GD3	41,44	ganglioside	GD3	CHEBI:28892	117189	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Phylogenetic conservation of ganglioside GD3 expression during early vertebrate ontogeny .
8228639	0	ganglioside	50,61	GD3	107,110	ganglioside	GD3	CHEBI:28892	117189	Chemical	Gene	antigen|amod|START_ENTITY melanoma-associated|dobj|antigen melanoma-associated|nmod|END_ENTITY	Characterization of a hamster melanoma-associated ganglioside antigen as 7-O-acetylated_disialoganglioside GD3 .
8721669	0	ganglioside	17,28	GD3	29,32	ganglioside	GD3	CHEBI:28892	117189	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	A reappraisal of ganglioside GD3 expression in the CNS .
8823358	0	ganglioside	43,54	GD3	39,42	ganglioside	GD3	CHEBI:28892	117189	Chemical	Gene	exhibit|amod|START_ENTITY exhibit|compound|END_ENTITY	Human melanoma_cell_lines_deficient in GD3 ganglioside expression exhibit altered growth and tumorigenic characteristics .
9287216	0	ganglioside	20,31	GD3	16,19	ganglioside	GD3	CHEBI:28892	117189	Chemical	Gene	START_ENTITY|nsubj|Requirement Requirement|nmod|END_ENTITY	Requirement for GD3 ganglioside in CD95 - and ceramide-induced apoptosis .
9578432	0	ganglioside	64,75	GD3	60,63	ganglioside	GD3	CHEBI:28892	117189	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|R24 R24|appos|antibody antibody|nmod|END_ENTITY	Anti-melanoma effects of R24 , a monoclonal antibody against GD3 ganglioside .
20219629	0	ganglioside	37,48	GM-1	32,36	ganglioside	GM-1	CHEBI:28892	210582(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|END_ENTITY	Protective effects of exogenous GM-1 ganglioside on acoustic_injury of the mouse cochlea .
1796128	0	ganglioside	107,118	GM1	103,106	ganglioside	GM1	CHEBI:28892	210582(Tax:10090)	Chemical	Gene	administration|compound|START_ENTITY administration|compound|END_ENTITY	Open field behaviours and spatial learning performance in C57BL/6 mice : early stage effects of chronic GM1 ganglioside administration .
19299701	0	ganglioside	21,32	GM1	17,20	ganglioside	GM1	CHEBI:28892	210582(Tax:10090)	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Cross-linking of GM1 ganglioside by galectin-1 mediates regulatory T cell activity involving TRPC5 channel activation : possible role in suppressing experimental_autoimmune_encephalomyelitis .
2314637	0	ganglioside	22,33	GM1	18,21	ganglioside	GM1	CHEBI:28892	210582(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of chronic GM1 ganglioside administration on passive avoidance retention in mice .
9668361	0	ganglioside	15,26	GM1	11,14	ganglioside	GM1	CHEBI:28892	210582(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of GM1 ganglioside treatment on dopamine innervation of the striatum of MPTP-treated mice .
12374215	0	ganglioside	23,34	GM2	19,22	ganglioside	GM2	CHEBI:28892	192986(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|compound|END_ENTITY	Restoration of the GM2 ganglioside metabolism in bone marrow-derived stromal cells from Tay-Sachs_disease animal model .
12630950	0	ganglioside	24,35	GM3	36,39	ganglioside	GM3	CHEBI:28892	110204(Tax:10090)	Chemical	Gene	changes|nmod|START_ENTITY END_ENTITY|nsubj|changes	Expressional changes of ganglioside GM3 during ovarian maturation and early embryonic development in db/db mice .
21324343	0	ganglioside	50,61	GM3	46,49	ganglioside	GM3	CHEBI:28892	110204(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|evaluation evaluation|nmod|END_ENTITY	Cytofluorimetric evaluation of N-glycolylated GM3 ganglioside expression on murine leukocytes .
6477558	0	ganglioside	67,78	HNK-1	24,29	ganglioside	HNK-1	CHEBI:28892	27087	Chemical	Gene	reacts|nmod|START_ENTITY reacts|nsubj|END_ENTITY	The monoclonal antibody HNK-1 reacts with a human peripheral nerve ganglioside .
12065629	0	ganglioside	4,15	Trk	58,61	ganglioside	Trk	CHEBI:28892	59109(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	GM1 ganglioside induces phosphorylation and activation of Trk and Erk in brain .
15656989	0	ganglioside	54,65	WNK1	24,28	ganglioside	WNK1	CHEBI:28892	232341(Tax:10090)	Chemical	Gene	analysis|amod|START_ENTITY END_ENTITY|nmod|analysis	Expression of the mouse WNK1 gene in correlation with ganglioside GD3 and functional analysis of the mouse WNK1 promoter .
10653586	0	ganglioside	33,44	caspase-3	15,24	ganglioside	caspase-3	CHEBI:28892	836	Chemical	Gene	START_ENTITY|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of caspase-3 and GD3 ganglioside in ceramide-induced apoptosis in Farber_disease .
23074226	0	ganglioside	59,70	myelin-associated_glycoprotein	96,126	ganglioside	myelin-associated glycoprotein	CHEBI:28892	17136(Tax:10090)	Chemical	Gene	levels|compound|START_ENTITY levels|nmod|END_ENTITY	Ablation of neuronal ceramide_synthase_1 in mice decreases ganglioside levels and expression of myelin-associated_glycoprotein in oligodendrocytes .
2779858	0	ganglioside	39,50	nerve_growth_factor	11,30	ganglioside	nerve growth factor	CHEBI:28892	310738(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of nerve_growth_factor and GM1 ganglioside on the number and size of cholinergic neurons in rats with unilateral lesion of the nucleus basalis .
3378149	0	ganglioside	4,15	nerve_growth_factor	42,61	ganglioside	nerve growth factor	CHEBI:28892	310738(Tax:10116)	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|effect effect|nmod|END_ENTITY	GM1 ganglioside potentiates the effect of nerve_growth_factor in preventing vinblastine-induced sympathectomy in newborn rats .
17929901	0	ganglioside	71,82	p53	31,34	ganglioside	p53	CHEBI:28892	7157	Chemical	Gene	modulation|nmod|START_ENTITY modulation|compound|END_ENTITY	Method for lipidomic analysis : p53 expression modulation of sulfatide , ganglioside , and phospholipid composition of U87 MG_glioblastoma cells .
20625494	0	ganglioside_GM1	24,39	CD4	54,57	ganglioside GM1	CD4	MESH:D005677	920	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Increased expression of ganglioside_GM1 in peripheral CD4 + T cells correlates soluble form of CD30 in Systemic_Lupus_Erythematosus patients .
9556610	0	ganglioside_GM1	35,50	Galectin-1	0,10	ganglioside GM1	Galectin-1	MESH:D005677	3956	Chemical	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	Galectin-1 is a major receptor for ganglioside_GM1 , a product of the growth-controlling activity of a cell surface ganglioside sialidase , on human neuroblastoma cells in culture .
12794304	0	ganglioside_GM1	44,59	PDGFRbeta	31,40	ganglioside GM1	PDGFRbeta	MESH:D005677	24629(Tax:10116)	Chemical	Gene	modulation|nmod|START_ENTITY modulation|nmod|END_ENTITY	Domain-dependent modulation of PDGFRbeta by ganglioside_GM1 .
21203834	0	ganglioside_GM3	70,85	epidermal_growth_factor_receptor	14,46	ganglioside GM3	epidermal growth factor receptor	MESH:D005679	1956	Chemical	Gene	interaction|nmod|START_ENTITY END_ENTITY|nmod|interaction	Regulation of epidermal_growth_factor_receptor through interaction of ganglioside_GM3 with GlcNAc of N-linked glycan of the receptor : demonstration in ldlD cells .
17367758	0	ganglioside_GM3	54,69	tumor_necrosis_factor-alpha	23,50	ganglioside GM3	tumor necrosis factor-alpha	MESH:D005679	21926(Tax:10090)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Positive regulation of tumor_necrosis_factor-alpha by ganglioside_GM3 through Akt in mouse melanoma B16 cells .
2493244	0	gangliosides	33,45	CD4	73,76	gangliosides	CD4	MESH:D005732	920	Chemical	Gene	START_ENTITY|nmod|modulation modulation|nmod|END_ENTITY	Characteristic mode of action of gangliosides in selective modulation of CD4 on human T lymphocytes .
3527721	0	gangliosides	77,89	interleukin_1	50,63	gangliosides	interleukin 1	MESH:D005732	3552	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of lipopolysaccharide-induced monocyte interleukin_1 secretion by gangliosides .
6609839	0	gangliosides	28,40	interleukin_2	11,24	gangliosides	interleukin 2	MESH:D005732	3558	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of interleukin_2 to gangliosides .
2824382	0	gangliosides	88,100	neurotoxin	52,62	gangliosides	neurotoxin	MESH:D005732	20490862	Chemical	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Antigenic structure of Clostridium_botulinum type B neurotoxin and its interaction with gangliosides , cerebroside , and free fatty_acids .
23117335	0	gangliosides	16,28	p125FAK	60,67	gangliosides	p125FAK	MESH:D005732	5747	Chemical	Gene	START_ENTITY|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Effect of tumor gangliosides on tyrosine phosphorylation of p125FAK in platelet adhesion to collagen .
8110807	0	gangliosides	14,26	phospholipase_A2	45,61	gangliosides	phospholipase A2	MESH:D005732	151056	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|activity activity|amod|END_ENTITY	Regulation by gangliosides and sulfatides of phospholipase_A2 activity against dipalmitoyl - and dilauroylphosphatidylcholine in small unilamellar bilayer vesicles and mixed monolayers .
16320409	0	gangrene	80,88	basic_fibroblast_growth_factor	38,68	gangrene	basic fibroblast growth factor	null	2247	Chemical	Gene	treatment|nmod|START_ENTITY treatment|nmod|END_ENTITY	Aluminum foil treatment combined with basic_fibroblast_growth_factor -LRB- bFGF -RRB- for gangrene of the fingertip caused by collagen disease .
6416538	0	gangrene	25,33	vasopressin	75,86	gangrene	vasopressin	null	551	Chemical	Gene	START_ENTITY|nmod|infusion infusion|nmod|END_ENTITY	Development of cutaneous gangrene during continuous peripheral infusion of vasopressin .
17822918	0	ganstigmine	45,56	acetylcholinesterase	76,96	ganstigmine	acetylcholinesterase	MESH:C447079	83817(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|inhibitor inhibitor|compound|END_ENTITY	Neurochemical and neurobehavioral effects of ganstigmine -LRB- CHF2819 -RRB- , a novel acetylcholinesterase inhibitor , in rat prefrontal cortex : an in vivo study .
19426689	0	garcinol	145,153	5-lipoxygenase	18,32	garcinol	5-lipoxygenase	MESH:C054597	240	Chemical	Gene	Identification|nmod|START_ENTITY Identification|nmod|targets targets|amod|END_ENTITY	Identification of 5-lipoxygenase and microsomal prostaglandin_E2 synthase-1 as functional targets of the anti-inflammatory and anti-carcinogenic garcinol .
23137051	0	garcinol	131,139	5-lipoxygenase	105,119	garcinol	5-lipoxygenase	MESH:C054597	240	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Chemoprevention of 7,12-dimethylbenz -LSB- a -RSB- anthracene -LRB- DMBA -RRB- - induced hamster cheek pouch carcinogenesis by a 5-lipoxygenase inhibitor , garcinol .
24417609	0	garcinol	22,30	STAT-1	133,139	garcinol	STAT-1	MESH:C054597	6772	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Direct interaction of garcinol and related_polyisoprenylated_benzophenones of Garcinia cambogia fruits with the transcription factor STAT-1 as a likely mechanism of their inhibitory effect on cytokine signaling pathways .
24533688	0	garcinol	31,39	p21	13,16	garcinol	p21	MESH:C054597	1026	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of p21 -LRB- Waf1/Cip1 -RRB- by garcinol via downregulation of p38-MAPK signaling in p53-independent H1299 lung_cancer .
11977525	0	gardenoside	59,70	Hao	83,86	gardenoside	Hao	MESH:C056587	23498	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of different compounding of formulae on content of gardenoside in Yin Chen Hao decoction .
21762685	0	garenoxacin	29,40	IL-8	44,48	garenoxacin	IL-8	MESH:C419689	3576	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Anti-inflammatory effects of garenoxacin on IL-8 production and ERK1/2 activation induced by lipopolysaccharides in A549 and THP-1 cells .
18826099	0	garlicin	11,19	interleukin_4	43,56	garlicin	interleukin 4	MESH:C028009	287287(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|levels levels|nmod|END_ENTITY	-LSB- Effect of garlicin on the serum levels of interleukin_4 and interferon_gamma in allergic_rhinitis model in rats -RSB- .
26792678	0	gasoline	57,65	Hsp70	38,43	gasoline	Hsp70	MESH:D005742	3308	Chemical	Gene	levels|nmod|START_ENTITY levels|amod|END_ENTITY	Increased oxidative stress and plasma Hsp70 levels among gasoline filling station attendants .
12381523	0	gastric_acid	52,64	EGF_receptors	7,20	gastric acid	EGF receptors	null	1956	Chemical	Gene	regulate|nmod|START_ENTITY regulate|nsubj|END_ENTITY	Apical EGF_receptors regulate epithelial barrier to gastric_acid : endogenous TGF-alpha is an essential facilitator .
15350696	0	gastric_acid	17,29	Galanin	0,7	gastric acid	Galanin	null	14419(Tax:10090)	Chemical	Gene	secretion|amod|START_ENTITY inhibits|dobj|secretion inhibits|nsubj|END_ENTITY	Galanin inhibits gastric_acid secretion through a somatostatin-independent mechanism in mice .
11027567	0	gastric_acid	19,31	Ghrelin	0,7	gastric acid	Ghrelin	null	59301(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|stimulates stimulates|compound|END_ENTITY	Ghrelin stimulates gastric_acid secretion and motility in rats .
22723266	0	gastric_acid	20,32	Nesfatin-1	0,10	gastric acid	Nesfatin-1	null	59295(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY inhibits|dobj|secretion inhibits|nsubj|END_ENTITY	Nesfatin-1 inhibits gastric_acid secretion via a central vagal mechanism in rats .
11557520	0	gastric_acid	17,29	PACAP	0,5	gastric acid	PACAP	null	24166(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|stimulates stimulates|compound|END_ENTITY	PACAP stimulates gastric_acid secretion in the rat by inducing histamine release .
15023860	0	gastric_acid	26,38	PACAP	11,16	gastric acid	PACAP	null	11516(Tax:10090)	Chemical	Gene	secretion|amod|START_ENTITY inhibits|dobj|secretion inhibits|nsubj|END_ENTITY	Peripheral PACAP inhibits gastric_acid secretion through somatostatin release in mice .
8532587	0	gastric_acid	19,31	PACAP	10,15	gastric acid	PACAP	null	24166(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY Effect|nmod|secretion Effect|nmod|END_ENTITY	Effect of PACAP on gastric_acid secretion in rats .
1364034	0	gastric_acid	20,32	Peptide_YY	0,10	gastric acid	Peptide YY	null	5697	Chemical	Gene	secretion|amod|START_ENTITY inhibits|dobj|secretion inhibits|nsubj|END_ENTITY	Peptide_YY inhibits gastric_acid secretion stimulated by the autonomic nervous system .
9655680	0	gastric_acid	18,30	Secretin	0,8	gastric acid	Secretin	null	24769(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY inhibits|dobj|secretion inhibits|nsubj|END_ENTITY	Secretin inhibits gastric_acid secretion via a vagal afferent pathway in rats .
9374800	0	gastric_acid	40,52	TRH	21,24	gastric acid	TRH	null	25569(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY secretion|compound|END_ENTITY	5-CT or DOI augments TRH analog-induced gastric_acid secretion at the dorsal vagal complex .
2959490	0	gastric_acid	31,43	atrial_natriuretic_peptide	96,122	gastric acid	atrial natriuretic peptide	null	24602(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY secretion|nmod|END_ENTITY	Vagal-dependent stimulation of gastric_acid secretion by intracerebroventricularly administered atrial_natriuretic_peptide in anaesthetized rats .
7292006	0	gastric_acid	37,49	calcitonin	17,27	gastric acid	calcitonin	null	24241(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY inhibits|dobj|secretion inhibits|nsubj|END_ENTITY	Intraventricular calcitonin inhibits gastric_acid secretion .
11093953	0	gastric_acid	39,51	cyclooxygenase-2	8,24	gastric acid	cyclooxygenase-2	null	29527(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of cyclooxygenase-2 in modulating gastric_acid secretion in the normal and inflamed rat stomach .
1188305	0	gastric_acid	32,44	gastrin	14,21	gastric acid	gastrin	null	2520	Chemical	Gene	START_ENTITY|nsubj|serum serum|amod|END_ENTITY	Fasting serum gastrin and basal gastric_acid secretion .
1274921	0	gastric_acid	48,60	gastrin	71,78	gastric acid	gastrin	null	2520	Chemical	Gene	response|compound|START_ENTITY response|compound|END_ENTITY	Effect of synthetic 15-methyl analog of PGE2 on gastric_acid and serum gastrin response to peptone meal , pentagastrin , and histamine in duodenal ulcer patients .
2263169	0	gastric_acid	57,69	gastrin	25,32	gastric acid	gastrin	null	25320(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY secretion|amod|END_ENTITY	Effects of lorglumide on gastrin - and peptone-stimulated gastric_acid secretion in rats .
2466671	0	gastric_acid	41,53	gastrin	85,92	gastric acid	gastrin	null	100685087	Chemical	Gene	secretion|amod|START_ENTITY secretion|nmod|END_ENTITY	An analysis of the effects of galanin on gastric_acid secretion and plasma levels of gastrin in the dog .
3557000	0	gastric_acid	36,48	gastrin	25,32	gastric acid	gastrin	null	2520	Chemical	Gene	contribution|acl|START_ENTITY contribution|nmod|END_ENTITY	Variable contribution of gastrin to gastric_acid secretion after a meal in humans .
7223301	0	gastric_acid	13,25	gastrin	36,43	gastric acid	gastrin	null	2520	Chemical	Gene	Secretion|nmod|START_ENTITY END_ENTITY|nsubj|Secretion	Secretion of gastric_acid and serum gastrin following antral exclusion in man .
7435122	0	gastric_acid	30,42	gastrin	21,28	gastric acid	gastrin	null	2520	Chemical	Gene	START_ENTITY|nsubj|relation relation|nmod|END_ENTITY	The relation between gastrin , gastric_acid and thyroid_function_disorders .
18097287	0	gastric_acid	41,53	mucin	15,20	gastric acid	mucin	null	100508689	Chemical	Gene	START_ENTITY|nsubj|secretion secretion|compound|END_ENTITY	Higher gastric mucin secretion and lower gastric_acid output in first-degree relatives of gastric_cancer patients .
2318089	0	gastric_acid	36,48	neurotensin	21,32	gastric acid	neurotensin	null	299757(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY effect|nmod|secretion effect|nmod|END_ENTITY	Inhibitory effect of neurotensin on gastric_acid secretion in rats .
2551763	0	gastric_acid	29,41	neurotensin	8,19	gastric acid	neurotensin	null	299757(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY inhibits|dobj|secretion inhibits|nsubj|END_ENTITY	Central neurotensin inhibits gastric_acid secretion : an adrenergic mechanism in rats .
9920789	0	gastric_acid	15,27	orexin-A	64,72	gastric acid	orexin-A	null	25723(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY secretion|nmod|END_ENTITY	Stimulation of gastric_acid secretion by centrally administered orexin-A in conscious rats .
1971469	0	gastric_acid	24,36	peptide_YY	10,20	gastric acid	peptide YY	null	287730(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY END_ENTITY|nmod|secretion	Effect of peptide_YY on gastric_acid secretion , gastrin and somatostatin release in the rat .
2595285	0	gastric_acid	35,47	peptide_YY	21,31	gastric acid	peptide YY	null	287730(Tax:10116)	Chemical	Gene	output|amod|START_ENTITY effect|nmod|output effect|nmod|END_ENTITY	Inhibitory effect of peptide_YY on gastric_acid output in rats .
10499878	0	gastric_acid	53,65	somatostatin	17,29	gastric acid	somatostatin	null	24797(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Urethane-induced somatostatin mediated inhibition of gastric_acid : reversal by the somatostatin 2 receptor antagonist , PRL-2903 .
12354575	0	gastric_acid	40,52	somatostatin	24,36	gastric acid	somatostatin	null	20604(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Antisecretory effect of somatostatin on gastric_acid via inhibition of histamine release in isolated mouse stomach .
2858159	0	gastric_acid	39,51	somatostatin	23,35	gastric acid	somatostatin	null	24797(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY effects|nmod|secretion effects|nmod|END_ENTITY	Dissociated effects of somatostatin on gastric_acid secretion and mucosal blood flow .
2862691	0	gastric_acid	49,61	somatostatin	10,22	gastric acid	somatostatin	null	403993(Tax:9615)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of somatostatin on bethanechol-stimulated gastric_acid secretion and gastric_antral_motility in dogs with gastric_fistula .
2875517	0	gastric_acid	47,59	somatostatin	10,22	gastric acid	somatostatin	null	403993(Tax:9615)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of somatostatin on histamine-stimulated gastric_acid and pepsin secretion in dogs .
9609748	0	gastric_acid	11,23	somatostatin_receptor_subtype_2	37,68	gastric acid	somatostatin receptor subtype 2	null	20606(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	High basal gastric_acid secretion in somatostatin_receptor_subtype_2 knockout mice .
6818683	0	gastric_acid	43,55	thyrotropin-releasing_hormone	10,39	gastric acid	thyrotropin-releasing hormone	null	7200	Chemical	Gene	secretion|amod|START_ENTITY Effect|nmod|secretion Effect|nmod|END_ENTITY	Effect of thyrotropin-releasing_hormone on gastric_acid secretion in man .
8281854	0	gastric_acid	46,58	transforming_growth_factor-alpha	10,42	gastric acid	transforming growth factor-alpha	null	24827(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY Effect|nmod|secretion Effect|nmod|END_ENTITY	Effect of transforming_growth_factor-alpha on gastric_acid secretion in rats and monkeys .
19673887	0	gefitinib	48,57	BRAK	15,19	gefitinib	BRAK	MESH:C419708	9547	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Restoration of BRAK / CXCL14 gene expression by gefitinib is associated with antitumor efficacy of the drug in head_and_neck_squamous_cell_carcinoma .
26722478	0	gefitinib	67,76	BRCA1	18,23	gefitinib	BRCA1	MESH:C419708	672	Chemical	Gene	attenuates|nmod|START_ENTITY attenuates|nsubj|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of BRCA1 attenuates the sensitivity of PC9 cells to gefitinib .
19673887	0	gefitinib	48,57	CXCL14	22,28	gefitinib	CXCL14	MESH:C419708	9547	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Restoration of BRAK / CXCL14 gene expression by gefitinib is associated with antitumor efficacy of the drug in head_and_neck_squamous_cell_carcinoma .
21187468	0	gefitinib	19,28	EGF	48,51	gefitinib	EGF	MESH:C419708	1950	Chemical	Gene	response|nmod|START_ENTITY associated|nsubjpass|response associated|nmod|END_ENTITY	Tumour response to gefitinib is associated with EGF - and gefitinib - but not radiation-modulated EGFR expression .
14582710	0	gefitinib	69,78	EGFR	38,42	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	kinase|dobj|START_ENTITY kinase|nsubj|response response|nmod|tyrosine tyrosine|amod|END_ENTITY	Clinically meaningful response to the EGFR tyrosine kinase inhibitor gefitinib -LRB- ` Iressa ' , ZD1839 -RRB- in non_small_cell_lung_cancer .
14639003	0	gefitinib	32,41	EGFR	0,4	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	tyrosine|xcomp|START_ENTITY tyrosine|nsubj|END_ENTITY	EGFR tyrosine kinase inhibitor `` gefitinib -LRB- Iressa -RRB- '' for cancer therapy .
15118125	0	gefitinib	69,78	EGFR	0,4	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	therapy|amod|START_ENTITY response|nmod|therapy correlation|nmod|response mutations|dep|correlation mutations|amod|END_ENTITY	EGFR mutations in lung_cancer : correlation with clinical response to gefitinib therapy .
15386420	0	gefitinib	96,105	EGFR	34,38	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	markers|nmod|START_ENTITY Epidermal_growth_factor_receptor|nmod|markers Epidermal_growth_factor_receptor|dobj|molecules molecules|appos|END_ENTITY	Epidermal_growth_factor_receptor -LRB- EGFR -RRB- downstream molecules as response predictive markers for gefitinib -LRB- Iressa , ZD1839 -RRB- in chemotherapy-resistant non-small_cell_lung_cancer .
15492792	0	gefitinib	95,104	EGFR	37,41	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|phosphorylation phosphorylation|compound|END_ENTITY	Small_cell_lung_cancer cells express EGFR and tyrosine phosphorylation of EGFR is inhibited by gefitinib -LRB- `` Iressa '' , ZD1839 -RRB- .
15492792	0	gefitinib	95,104	EGFR	74,78	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|phosphorylation phosphorylation|nmod|END_ENTITY	Small_cell_lung_cancer cells express EGFR and tyrosine phosphorylation of EGFR is inhibited by gefitinib -LRB- `` Iressa '' , ZD1839 -RRB- .
15728811	0	gefitinib	62,71	EGFR	0,4	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	mutation|nmod|START_ENTITY mutation|compound|END_ENTITY	EGFR mutation and resistance of non-small-cell_lung_cancer to gefitinib .
15737014	0	gefitinib	47,56	EGFR	114,118	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	lung_adenocarcinomas|nmod|START_ENTITY resistance|nmod|lung_adenocarcinomas associated|nsubjpass|resistance associated|nmod|mutation mutation|nmod|domain domain|amod|END_ENTITY	Acquired resistance of lung_adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain .
15767641	5	gefitinib	819,828	EGFR	760,764	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	involving|dobj|START_ENTITY present|advcl|involving present|dobj|knowledge knowledge|nmod|mutations mutations|amod|END_ENTITY	Here , we present current knowledge about EGFR mutations in the context of clinical trials involving gefitinib and erlotinib in NSCLC .
16009451	0	gefitinib	12,21	EGFR	72,76	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	START_ENTITY|nmod|absence absence|nmod|mutation mutation|amod|END_ENTITY	Response to gefitinib in bronchioloalveolar_carcinoma in the absence of EGFR mutation .
16011858	0	gefitinib	73,82	EGFR	47,51	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	response|amod|START_ENTITY associated|nmod|response associated|nsubj|Mutations Mutations|nmod|domain domain|nmod|gene gene|amod|END_ENTITY	Mutations in the tyrosine kinase domain of the EGFR gene associated with gefitinib response in non-small-cell_lung_cancer .
16052537	0	gefitinib	48,57	EGFR	7,11	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	conferring|advcl|START_ENTITY mutations|acl|conferring mutations|compound|END_ENTITY	Common EGFR mutations conferring sensitivity to gefitinib in lung_adenocarcinoma are not prevalent in human malignant_mesothelioma .
16189524	0	gefitinib	25,34	EGFR	62,66	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	response|nmod|START_ENTITY response|acl|expressing expressing|dobj|END_ENTITY	Differential response to gefitinib of cells expressing normal EGFR and the mutant EGFRvIII .
16330885	0	gefitinib	116,125	EGFR	0,4	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	experience|nmod|START_ENTITY report|nmod|experience inhibitors|dep|report inhibitors|amod|END_ENTITY	EGFR tyrosine kinase inhibitors in non-small_cell_lung_cancer : report of a 3-year_compassionate use experience with gefitinib in stage IIIB/IV outpatients .
16334173	0	gefitinib	85,94	EGFR	14,18	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	experience|nmod|START_ENTITY Inhibition|dep|experience Inhibition|nmod|tyrosine-kinase tyrosine-kinase|amod|END_ENTITY	Inhibition of EGFR tyrosine-kinase in NSCLC treatment : the Hungarian experience with gefitinib in the context of an expanded access programme .
16507511	0	gefitinib	82,91	EGFR	130,134	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	metabolite|nmod|START_ENTITY contribution|appos|metabolite contribution|dep|epidermal_growth_factor_receptor epidermal_growth_factor_receptor|appos|END_ENTITY	Minimal contribution of desmethyl-gefitinib , the major human plasma metabolite of gefitinib , to epidermal_growth_factor_receptor -LRB- EGFR -RRB- - mediated tumour growth inhibition .
16510849	0	gefitinib	100,109	EGFR	0,4	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	efficacy|nmod|START_ENTITY association|nmod|efficacy mutations|dep|association mutations|amod|END_ENTITY	EGFR mutations in patients with brain metastases from lung_cancer : association with the efficacy of gefitinib .
16713012	0	gefitinib	37,46	EGFR	118,122	gefitinib	EGFR	MESH:C419708	13649(Tax:10090)	Chemical	Gene	combinations|nmod|START_ENTITY Effects|nmod|combinations Effects|acl|expressing expressing|dobj|END_ENTITY	Effects of different combinations of gefitinib and irinotecan in lung_cancer cell lines expressing wild or deletional EGFR .
16730855	0	gefitinib	48,57	EGFR	40,44	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	non-small-cell_lung_cancer|amod|START_ENTITY END_ENTITY|nmod|non-small-cell_lung_cancer	Double mutation and gene copy number of EGFR in gefitinib refractory non-small-cell_lung_cancer .
16731747	1	gefitinib	265,274	EGFR	212,216	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	linked|nmod|START_ENTITY linked|csubjpass|Activating Activating|dobj|mutations mutations|appos|END_ENTITY	Activating epidermal_growth_factor_receptor -LRB- EGFR -RRB- mutations have been linked with sensitivity to gefitinib and erlotinib ; however , there are no established predictive markers for response to the combination of EGFR inhibitors with standard chemotherapy in non-small_cell_lung_cancer -LRB- NSCLC -RRB- patients .
16818711	0	gefitinib	150,159	EGFR	95,99	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	amplification|nmod|START_ENTITY amplification|nsubj|Signaling Signaling|appos|END_ENTITY	Signaling via ErbB2 and ErbB3 associates with resistance and epidermal_growth_factor_receptor -LRB- EGFR -RRB- amplification with sensitivity to EGFR inhibitor gefitinib in head_and_neck_squamous_cell_carcinoma cells .
16921488	0	gefitinib	90,99	EGFR	14,18	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	outcome|nmod|START_ENTITY predict|dobj|outcome screening|xcomp|predict mutation|acl|screening mutation|amod|END_ENTITY	Usefulness of EGFR mutation screening in pleural fluid to predict the clinical outcome of gefitinib treated patients with lung_cancer .
16927343	0	gefitinib	53,62	EGFR	10,14	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	sensitivity|nmod|START_ENTITY mutations|nmod|sensitivity mutations|amod|END_ENTITY	Impact of EGFR point mutations on the sensitivity to gefitinib : insights from comparative structural analyses and molecular dynamics simulations .
16988945	0	gefitinib	66,75	EGFR	17,21	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	sensitivity|nmod|START_ENTITY cross-talks|nmod|sensitivity cross-talks|amod|END_ENTITY	Impact of IGF-1R / EGFR cross-talks on hepatoma cell sensitivity to gefitinib .
17045698	0	gefitinib	22,31	EGFR	82,86	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	Non-responsiveness|nmod|START_ENTITY Non-responsiveness|acl|having having|dobj|S768I S768I|compound|END_ENTITY	Non-responsiveness to gefitinib in a patient with lung_adenocarcinoma having rare EGFR mutations S768I and V769L .
17047654	0	gefitinib	161,170	EGFR	107,111	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	analysing|advcl|START_ENTITY analysing|dobj|mutations mutations|amod|END_ENTITY	Novel heteroduplex method using small cytology specimens with a remarkably high success rate for analysing EGFR gene mutations with a significant correlation to gefitinib efficacy in non-small-cell_lung_cancer .
17060940	0	gefitinib	123,132	EGFR	0,4	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	predicting|nmod|START_ENTITY basis|acl|predicting basis|nsubj|status status|amod|END_ENTITY	EGFR mutation status in tumour-derived DNA from pleural_effusion fluid is a practical basis for predicting the response to gefitinib .
17145836	0	gefitinib	92,101	EGFR	60,64	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	correlates|nsubj|START_ENTITY tyrosine|ccomp|correlates tyrosine|nsubj|activity activity|nmod|epidermal_growth_factor_receptor epidermal_growth_factor_receptor|appos|END_ENTITY	Antitumor activity of the epidermal_growth_factor_receptor -LRB- EGFR -RRB- tyrosine kinase inhibitor gefitinib -LRB- ZD1839 , Iressa -RRB- in non-small_cell_lung_cancer cell lines correlates with gene copy number and EGFR mutations but not EGFR protein levels .
17205515	1	gefitinib	141,150	EGFR	123,127	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	signaling|xcomp|START_ENTITY END_ENTITY|acl|signaling	Evidence linking EGFR signaling to gefitinib antitumor response .
17317677	0	gefitinib	139,148	EGFR	15,19	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	treated|nmod|START_ENTITY patients|acl|treated outcome|nmod|patients predicts|dobj|outcome predicts|nsubj|Combination Combination|nmod|number number|amod|END_ENTITY	Combination of EGFR gene copy number and protein expression predicts outcome for advanced non-small-cell_lung_cancer patients treated with gefitinib .
17335935	0	gefitinib	86,95	EGFR	0,4	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	predicts|xcomp|START_ENTITY predicts|nsubj|status status|amod|END_ENTITY	EGFR mutation status in pleural fluid predicts tumor responsiveness and resistance to gefitinib .
17361439	0	gefitinib	19,28	EGFR	73,77	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|endocytosis endocytosis|nmod|END_ENTITY	The EGFR inhibitor gefitinib suppresses ligand-stimulated endocytosis of EGFR via the early/late endocytic pathway in non-small_cell_lung_cancer cell lines .
17368623	0	gefitinib	46,55	EGFR	122,126	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	efficacy|nmod|START_ENTITY study|nmod|efficacy III/IV|nsubj|study III/IV|nmod|mutations mutations|amod|END_ENTITY	Phase II prospective study of the efficacy of gefitinib for the treatment of stage III/IV non-small_cell_lung_cancer with EGFR mutations , irrespective of previous chemotherapy .
17406029	0	gefitinib	11,20	EGFR	135,139	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	responsiveness|nsubj|START_ENTITY responsiveness|nmod|fluorescence fluorescence|nmod|hybridization/chromogenic hybridization/chromogenic|nmod|analysis analysis|nmod|END_ENTITY	Predicting gefitinib responsiveness in lung_cancer by fluorescence in situ hybridization/chromogenic in situ hybridization analysis of EGFR and HER2 in biopsy and cytology specimens .
17626639	0	gefitinib	77,86	EGFR	16,20	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	copy|advcl|START_ENTITY copy|nsubj|Correlations Correlations|nmod|mutations mutations|amod|END_ENTITY	Correlations of EGFR mutations and increases in EGFR and HER2 copy number to gefitinib response in a retrospective analysis of lung_cancer patients .
17626639	0	gefitinib	77,86	EGFR	48,52	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	copy|advcl|START_ENTITY copy|nsubj|Correlations Correlations|nmod|mutations mutations|nmod|END_ENTITY	Correlations of EGFR mutations and increases in EGFR and HER2 copy number to gefitinib response in a retrospective analysis of lung_cancer patients .
17695517	0	gefitinib	42,51	EGFR	125,129	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	mechanism|acl|START_ENTITY mechanism|dep|role role|nmod|mutation mutation|nmod|exon exon|nmod|END_ENTITY	A new mechanism for primary resistance to gefitinib in lung_adenocarcinoma : the role of a novel G796A mutation in exon 20 of EGFR .
17713473	0	gefitinib	83,92	EGFR	26,30	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	receiving|dobj|START_ENTITY polymorphisms|advcl|receiving polymorphisms|nmod|END_ENTITY	Germline polymorphisms in EGFR and survival in patients with lung_cancer receiving gefitinib .
18089823	0	gefitinib	135,144	EGFR	88,92	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	resistant|xcomp|START_ENTITY models|acl:relcl|resistant models|nmod|mutations mutations|compound|END_ENTITY	PF00299804 , an irreversible pan-ERBB inhibitor , is effective in lung_cancer models with EGFR and ERBB2 mutations that are resistant to gefitinib .
18093943	0	gefitinib	112,121	EGFR	60,64	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	resistance|nmod|START_ENTITY occurs|nmod|resistance occurs|nmod|mutations mutations|nmod|lung_tumors lung_tumors|amod|END_ENTITY	MET amplification occurs with or without T790M mutations in EGFR mutant lung_tumors with acquired resistance to gefitinib or erlotinib .
18097577	0	gefitinib	98,107	EGFR	15,19	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	lines|nmod|START_ENTITY Involvement|nmod|lines Involvement|nmod|END_ENTITY	Involvement of EGFR in the response of squamous_cell_carcinoma of the head_and_neck cell lines to gefitinib .
18196873	0	gefitinib	11,20	EGFR	108,112	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	treatment|compound|START_ENTITY brought|nsubj|treatment brought|nmod|alterations alterations|amod|END_ENTITY	Short-term gefitinib treatment brought about a long-term regression of bronchioloalveolar_carcinoma without EGFR gene alterations : a case report .
18281523	0	gefitinib	54,63	EGFR	112,116	gefitinib	EGFR	MESH:C419708	13649(Tax:10090)	Chemical	Gene	models|nmod|START_ENTITY regimens|nsubj|models regimens|nmod|wild-type wild-type|amod|END_ENTITY	Preclinical pharmacokinetic/pharmacodynamic models of gefitinib and the design of equivalent dosing regimens in EGFR wild-type and mutant tumor models .
18304967	0	gefitinib	95,104	EGFR	0,4	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	expression|compound|START_ENTITY correlation|nmod|expression regulation|dep|correlation regulation|amod|END_ENTITY	EGFR regulation by microRNA in lung_cancer : correlation with clinical response and survival to gefitinib and EGFR expression in cell lines .
18458038	0	gefitinib	11,20	EGFR	92,96	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	START_ENTITY|acl|harboring harboring|dobj|mutations mutations|compound|END_ENTITY	First-line gefitinib in patients with advanced non-small-cell_lung_cancer harboring somatic EGFR mutations .
18509184	0	gefitinib	148,157	EGFR	9,13	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	receiving|dobj|START_ENTITY non-small-cell_lung_cancer|acl|receiving predict|nmod|non-small-cell_lung_cancer predict|nsubj|mutations mutations|compound|END_ENTITY	Specific EGFR mutations predict treatment outcome of stage IIIB/IV patients with chemotherapy-naive non-small-cell_lung_cancer receiving first-line gefitinib monotherapy .
18599154	0	gefitinib	71,80	EGFR	111,115	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	exposure|nmod|START_ENTITY derived|nmod|exposure transition|acl|derived Epithelial|nmod|transition determines|nsubj|Epithelial determines|nmod|inhibitors inhibitors|amod|END_ENTITY	Epithelial to mesenchymal transition derived from repeated exposure to gefitinib determines the sensitivity to EGFR inhibitors in A549 , a non-small_cell_lung_cancer cell line .
18625569	0	gefitinib	57,66	EGFR	0,4	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	treatment|amod|START_ENTITY confers|nmod|treatment confers|nsubj|mutation mutation|amod|END_ENTITY	EGFR mutation in kidney_carcinoma confers sensitivity to gefitinib treatment : a case report .
18637032	0	gefitinib	78,87	EGFR	47,51	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	kinase|dobj|START_ENTITY kinase|nsubj|activity activity|nmod|vitro vitro|nmod|tyrosine tyrosine|amod|END_ENTITY	Significant cytotoxic activity in vitro of the EGFR tyrosine kinase inhibitor gefitinib in acute_myeloblastic_leukaemia .
18785203	0	gefitinib	82,91	EGFR	0,4	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	resistance|compound|START_ENTITY contributing|nmod|resistance heterogeneity|acl|contributing heterogeneity|amod|END_ENTITY	EGFR genetic heterogeneity of nonsmall_cell_lung_cancers contributing to acquired gefitinib resistance .
18794545	0	gefitinib	163,172	EGFR	0,4	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	approval|amod|START_ENTITY treated|nmod|approval predict|parataxis|treated predict|nsubj|mutations mutations|amod|END_ENTITY	EGFR mutations predict survival benefit from gefitinib in patients with advanced_lung_adenocarcinoma : a historical comparison of patients treated before and after gefitinib approval in Japan .
18794545	0	gefitinib	45,54	EGFR	0,4	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	predict|nmod|START_ENTITY predict|nsubj|mutations mutations|amod|END_ENTITY	EGFR mutations predict survival benefit from gefitinib in patients with advanced_lung_adenocarcinoma : a historical comparison of patients treated before and after gefitinib approval in Japan .
18829487	9	gefitinib	1195,1204	EGFR	1159,1163	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	treated|nmod|START_ENTITY patient|acl:relcl|treated patient|nmod|mutation mutation|amod|END_ENTITY	A partial response was achieved in a patient -LRB- with an EGFR mutation -RRB- who was treated with gefitinib .
18980991	0	gefitinib	66,75	EGFR	93,97	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	START_ENTITY|nmod|cancers cancers|amod|END_ENTITY	Autocrine production of amphiregulin predicts sensitivity to both gefitinib and cetuximab in EGFR wild-type cancers .
18981003	0	gefitinib	84,93	EGFR	24,28	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	mutated|nmod|START_ENTITY mutated|nsubj|Effects Effects|nmod|erlotinib erlotinib|nmod|END_ENTITY	Effects of erlotinib in EGFR mutated non-small_cell_lung_cancers with resistance to gefitinib .
18995924	0	gefitinib	99,108	EGFR	0,4	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	treatment|amod|START_ENTITY associated|nmod|treatment associated|nsubjpass|polymorphism polymorphism|amod|END_ENTITY	EGFR intron 1 dinucleotide repeat polymorphism is associated with the occurrence of skin_rash with gefitinib treatment .
19020901	0	gefitinib	135,144	EGFR	0,4	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|mutations mutations|amod|END_ENTITY	EGFR mutations and HER2/3 protein expression and clinical outcome in Chinese advanced non-small_cell_lung_cancer patients treated with gefitinib .
19060236	0	gefitinib	17,26	EGFR	95,99	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	mutations|amod|START_ENTITY mutations|appos|END_ENTITY	Good response to gefitinib in lung_adenocarcinoma of complex epidermal_growth_factor_receptor -LRB- EGFR -RRB- mutations with the classical mutation pattern .
19155283	0	gefitinib	89,98	EGFR	25,29	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	outcome|amod|START_ENTITY response|nmod|outcome heterogeneity|dep|response heterogeneity|nmod|mutation mutation|amod|END_ENTITY	Genetic heterogeneity of EGFR mutation in pleomorphic_carcinoma of the lung : response to gefitinib and clinical outcome .
19247083	0	gefitinib	118,127	EGFR	0,4	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	treatment|nmod|START_ENTITY outcome|nmod|treatment impact|nmod|outcome gain|dep|impact gain|compound|END_ENTITY	EGFR and HER2 genomic gain in recurrent non-small_cell_lung_cancer after surgery : impact on outcome to treatment with gefitinib and association with EGFR and KRAS mutations in a Japanese cohort .
19247083	0	gefitinib	118,127	EGFR	149,153	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	treatment|nmod|START_ENTITY outcome|nmod|treatment impact|nmod|outcome impact|nmod|mutations mutations|compound|END_ENTITY	EGFR and HER2 genomic gain in recurrent non-small_cell_lung_cancer after surgery : impact on outcome to treatment with gefitinib and association with EGFR and KRAS mutations in a Japanese cohort .
19351754	0	gefitinib	39,48	EGFR	25,29	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	resistant|dep|START_ENTITY non-small_cell_lung_cancer|amod|resistant detection|nmod|non-small_cell_lung_cancer detection|nmod|T790M T790M|compound|END_ENTITY	Noninvasive detection of EGFR T790M in gefitinib or erlotinib resistant non-small_cell_lung_cancer .
19381047	0	gefitinib	96,105	EGFR	43,47	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	-RSB-|amod|START_ENTITY therapy|nmod|-RSB- responding|nmod|therapy mutation|acl|responding mutation|amod|END_ENTITY	-LSB- A case of non-small_cell_lung_cancer with EGFR mutation responding to S-1 after a therapy with gefitinib -RSB- .
19414383	0	gefitinib	22,31	EGFR	0,4	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	using|xcomp|START_ENTITY inhibition|acl|using inhibition|amod|END_ENTITY	EGFR inhibition using gefitinib is not active in neuroblastoma cell lines .
19531624	0	gefitinib	61,70	EGFR	107,111	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	trials|nmod|START_ENTITY analysis|nmod|trials analysis|nmod|mutations mutations|amod|END_ENTITY	Combined survival analysis of prospective clinical trials of gefitinib for non-small_cell_lung_cancer with EGFR mutations .
19650855	0	gefitinib	121,130	EGFR	58,62	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	treatment|amod|START_ENTITY non-small-cell_lung_cancer|nmod|treatment identifying|nmod|non-small-cell_lung_cancer identifying|dobj|mutation mutation|amod|END_ENTITY	Usefulness of cumulative smoking dose for identifying the EGFR mutation and patients with non-small-cell_lung_cancer for gefitinib treatment .
19671738	0	gefitinib	88,97	EGFR	36,40	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	reduced|xcomp|START_ENTITY show|dep|reduced show|nsubj|mutants mutants|acl|containing containing|dobj|types types|amod|END_ENTITY	Double EGFR mutants containing rare EGFR mutant types show reduced in vitro response to gefitinib compared with common activating missense mutations .
19671738	0	gefitinib	88,97	EGFR	7,11	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	reduced|xcomp|START_ENTITY show|dep|reduced show|nsubj|mutants mutants|amod|END_ENTITY	Double EGFR mutants containing rare EGFR mutant types show reduced in vitro response to gefitinib compared with common activating missense mutations .
19823028	0	gefitinib	21,30	EGFR	80,84	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|epidermal_growth_factor_receptor epidermal_growth_factor_receptor|appos|END_ENTITY	Molecular imaging of gefitinib activity in an epidermal_growth_factor_receptor -LRB- EGFR -RRB- - bearing xenograft model .
19887873	0	gefitinib	68,77	EGFR	16,20	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	lung_carcinoma|nmod|START_ENTITY lung_carcinoma|amod|END_ENTITY	Down-staging of EGFR mutation-positive advanced lung_carcinoma with gefitinib followed by surgical intervention : follow-up of two cases .
19921194	0	gefitinib	52,61	EGFR	101,105	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	START_ENTITY|dep|line line|nmod|mutation mutation|amod|END_ENTITY	Combined inhibition of IGFR enhances the effects of gefitinib in H1650 : a lung_cancer cell line with EGFR mutation and primary resistance to EGFR-TK inhibitors .
20361610	0	gefitinib	18,27	EGFR	114,118	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	Effectiveness|nmod|START_ENTITY Effectiveness|nmod|therapy therapy|nmod|non-small-cell_lung_cancer non-small-cell_lung_cancer|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Effectiveness of gefitinib -LRB- Iressa -RRB- as first-line therapy for inoperable non-small-cell_lung_cancer with mutated EGFR gene -LRB- phase II study -RRB- -RSB- .
20421816	0	gefitinib	30,39	EGFR	10,14	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	resistance|compound|START_ENTITY resistance|compound|END_ENTITY	Inducible EGFR T790M-mediated gefitinib resistance in non-small_cell_lung_cancer cells does not modulate sensitivity to PI103 provoked autophagy .
20430469	0	gefitinib	68,77	EGFR	171,175	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	efficacy|nmod|START_ENTITY evaluate|dobj|efficacy evaluate|xcomp|harboring harboring|dobj|mutations mutations|amod|END_ENTITY	A multicenter phase II study to evaluate the efficacy and safety of gefitinib as first-line treatment for Korean patients with advanced pulmonary_adenocarcinoma harboring EGFR mutations .
20716641	0	gefitinib	79,88	EGFR	167,171	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	resistance|amod|START_ENTITY resistance|acl|induced induced|nmod|mutation mutation|amod|END_ENTITY	TAK-701 , a humanized monoclonal antibody to hepatocyte_growth_factor , reverses gefitinib resistance induced by tumor-derived HGF in non-small_cell_lung_cancer with an EGFR mutation .
20832137	0	gefitinib	14,23	EGFR	74,78	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|mutations mutations|amod|END_ENTITY	Comparison of gefitinib and erlotinib in advanced NSCLC and the effect of EGFR mutations .
20956191	0	gefitinib	49,58	EGFR	27,31	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	experience|nmod|START_ENTITY challenge|dep|experience challenge|acl|targeting targeting|dobj|END_ENTITY	The challenge of targeting EGFR : experience with gefitinib in nonsmall_cell_lung_cancer .
21558399	0	gefitinib	130,139	EGFR	221,225	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	response|nmod|START_ENTITY response|nmod|domain domain|nmod|gene gene|amod|END_ENTITY	Molecular characteristics predict clinical outcomes : prospective trial correlating response to the EGFR tyrosine kinase inhibitor gefitinib with the presence of sensitizing mutations in the tyrosine binding domain of the EGFR gene .
21628735	0	gefitinib	22,31	EGFR	86,90	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|lung_carcinomas lung_carcinomas|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Antitumor effects of gefitinib for metastatic brain_tumors from lung_carcinomas with EGFR mutation -RSB- .
21660955	0	gefitinib	106,115	EGFR	27,31	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	alters|nmod|START_ENTITY alters|nsubj|localization localization|nmod|END_ENTITY	Lipid raft localization of EGFR alters the response of cancer cells to the EGFR tyrosine kinase inhibitor gefitinib .
21761561	0	gefitinib	105,114	EGFR	90,94	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	treatments|compound|START_ENTITY treatments|amod|END_ENTITY	Proteomic analysis identifies differentially expressed proteins after HDAC vorinostat and EGFR inhibitor gefitinib treatments in Hep-2 cancer cells .
21788562	0	gefitinib	59,68	EGFR	22,26	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	treatment|amod|START_ENTITY predicts|nmod|treatment predicts|nsubj|abundance abundance|nmod|mutations mutations|amod|END_ENTITY	Relative abundance of EGFR mutations predicts benefit from gefitinib treatment for advanced non-small-cell lung_cancer .
21915635	0	gefitinib	124,133	EGFR	14,18	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	interactions|nmod|START_ENTITY correlates|nmod|interactions correlates|nsubj|Inhibition Inhibition|nmod|phosphorylation phosphorylation|amod|END_ENTITY	Inhibition of EGFR phosphorylation in a panel of human breast_cancer cells correlates with synergistic interactions between gefitinib and 5 ' - DFUR , the bioactive metabolite of Xeloda .
22252115	0	gefitinib	34,43	EGFR	8,12	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	treatment|amod|START_ENTITY benefiting|dobj|treatment Lack|acl|benefiting Lack|nmod|mutations mutations|amod|END_ENTITY	Lack of EGFR mutations benefiting gefitinib treatment in adenocarcinoma of esophagogastric junction .
22548830	0	gefitinib	35,44	EGFR	19,23	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Interaction of the EGFR inhibitors gefitinib , vandetanib , pelitinib and neratinib with the ABCG2 multidrug transporter : implications for the emergence and reversal of cancer drug resistance .
22657099	0	gefitinib	110,119	EGFR	77,81	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	resolution|nmod|START_ENTITY resolution|nmod|forms forms|nmod|effects effects|compound|END_ENTITY	Temporal resolution of autophosphorylation for normal and oncogenic forms of EGFR and differential effects of gefitinib .
22733536	0	gefitinib	22,31	EGFR	147,151	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	impact|nmod|START_ENTITY versus|nsubj|impact versus|nmod|mutations mutations|amod|END_ENTITY	The impact of initial gefitinib or erlotinib versus chemotherapy on central nervous system progression in advanced non-small_cell_lung_cancer with EGFR mutations .
22760226	3	gefitinib	728,737	EGFR	718,722	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	TKIs|amod|START_ENTITY TKIs|compound|END_ENTITY	METHODS : We retrospectively analyzed clinical outcomes , including RR , PFS , and OS , in patients who were treated with the EGFR TKIs gefitinib or erlotinib and compared the results with those of adenocarcinoma patients with EGFR mutation and non-adenocarcinoma patients with wild-type EGFR .
22863020	9	gefitinib	1299,1308	EGFR	1246,1250	gefitinib	TGFa	MESH:C419708	7124	Chemical	Gene	caused|nmod|START_ENTITY caused|nsubj|introduction introduction|nmod|gene gene|compound|END_ENTITY	Finally , introduction of the wild-type EGFR gene into the HCC827 cells caused resistance to gefitinib under hypoxia .
22870104	0	gefitinib	242,251	EGFR	152,156	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	efficacy|amod|START_ENTITY implication|nmod|efficacy synthesis|dep|implication synthesis|amod|END_ENTITY	Heterozygous mutation -LRB- G/G _ > _ G/A -RRB- at nt 2607 of the EGFR gene is closely associated with increases in EGFR copy number and mRNA half life , but impaired EGFR protein synthesis in squamous_cell_carcinomas_of_the_head_and_neck - implication for gefitinib efficacy .
22922680	0	gefitinib	62,71	EGFR	142,146	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	Erosive_pustular_dermatosis_of_the_scalp-like_eruption|amod|START_ENTITY Erosive_pustular_dermatosis_of_the_scalp-like_eruption|dep|report report|nmod|literature literature|nmod|alopecia alopecia|acl|associated associated|nmod|inhibitors inhibitors|amod|END_ENTITY	Erosive_pustular_dermatosis_of_the_scalp-like_eruption due to gefitinib : case report and review of the literature of alopecia associated with EGFR inhibitors .
22967997	0	gefitinib	77,86	EGFR	174,178	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	comparing|dobj|START_ENTITY comparing|nmod|carboplatin-paclitaxel carboplatin-paclitaxel|nmod|non-small_cell_lung_cancer non-small_cell_lung_cancer|nmod|mutations mutations|compound|END_ENTITY	Updated overall survival results from a randomized phase III trial comparing gefitinib with carboplatin-paclitaxel for chemo-na ve non-small_cell_lung_cancer with sensitive EGFR gene mutations -LRB- NEJ002 -RRB- .
22969870	2	gefitinib	378,387	EGFR	457,461	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	efficacy|nmod|START_ENTITY compare|dobj|efficacy compare|nmod|patients patients|nmod|pulmonary_adenocarcinoma pulmonary_adenocarcinoma|acl:relcl|known known|nsubjpass|status status|amod|END_ENTITY	The objective of the present study was to compare the efficacy of gefitinib and erlotinib in patients with pulmonary_adenocarcinoma , whose tumor EGFR mutation status was known .
22985911	0	gefitinib	57,66	EGFR	26,30	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	tyrosine|dobj|START_ENTITY tyrosine|nsubj|effect effect|nmod|END_ENTITY	The synergistic effect of EGFR tyrosine kinase inhibitor gefitinib in combination with aromatase inhibitor anastrozole in non-small cell lung_cancer cell lines .
22989454	0	gefitinib	110,119	EGFR	1,5	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	-RSB-|amod|START_ENTITY effect|nmod|-RSB- statuses|nmod|effect statuses|nsubj|mutation mutation|amod|END_ENTITY	-LSB- EGFR gene mutation statuses in advanced non-small_cell_lung_cancer patients and their influence on effect of gefitinib -RSB- .
23021771	0	gefitinib	108,117	EGFR	87,91	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	treatment|amod|START_ENTITY harboring|nmod|treatment harboring|dobj|mutation mutation|amod|END_ENTITY	Miliary brain metastases in 2 cases with advanced non-small_cell_lung_cancer harboring EGFR mutation during gefitinib treatment .
23261231	0	gefitinib	25,34	EGFR	96,100	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	patients|amod|START_ENTITY treatment|nmod|patients treatment|nmod|mutations mutations|compound|END_ENTITY	Continued treatment with gefitinib beyond progressive_disease benefits patients with activating EGFR mutations .
23291074	0	gefitinib	44,53	EGFR	125,129	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	failure|nmod|START_ENTITY Efficacy|nmod|failure Efficacy|nmod|patients patients|nmod|metastasis metastasis|nmod|non-small_cell_lung_cancer non-small_cell_lung_cancer|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Efficacy of erlotinib after the failure of gefitinib in patients with metastasis of non-small_cell_lung_cancer with unknown EGFR mutation status -RSB- .
23360224	0	gefitinib	12,21	EGFR	76,80	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	switch|nsubj|START_ENTITY switch|nmod|non-small_cell_lung_cancer non-small_cell_lung_cancer|amod|END_ENTITY	Gene-guided gefitinib switch maintenance therapy for patients with advanced EGFR mutation-positive non-small_cell_lung_cancer : an economic analysis .
23402326	0	gefitinib	62,71	EGFR	53,57	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	resistance|amod|START_ENTITY resistance|compound|END_ENTITY	Association of integrin_beta1 and c-MET in mediating EGFR TKI gefitinib resistance in non-small_cell_lung_cancer .
23601301	0	gefitinib	36,45	EGFR	88,92	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	analysis|nmod|START_ENTITY -LSB-|dobj|analysis -LSB-|nmod|treatment treatment|nmod|patients patients|compound|END_ENTITY	-LSB- The cost-effectiveness analysis of gefitinib or erlotinib in the treatment of advanced EGFR mutant non-small_cell_lung_cancer patients -RSB- .
23683537	0	gefitinib	110,119	EGFR	15,19	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	response|nmod|START_ENTITY review|nmod|response Coexistence|dep|review Coexistence|nmod|mutation mutation|amod|END_ENTITY	Coexistence of EGFR mutation and ALK translocation in NSCLC : literature review and case report of response to gefitinib .
23695170	0	gefitinib	63,72	EGFR	86,90	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Synergistic effects of metformin treatment in combination with gefitinib , a selective EGFR tyrosine kinase inhibitor , in LKB1 wild-type NSCLC cell lines .
23733083	4	gefitinib	703,712	EGFR	511,515	gefitinib	EML4	MESH:C419708	27436	Chemical	Gene	crizotinib|compound|START_ENTITY inhibitors|appos|crizotinib markers|nsubj|inhibitors markers|dep|important important|nsubj|CONCLUSION CONCLUSION|dep|mutations mutations|amod|END_ENTITY	CONCLUSION : EGFR activating mutations -LRB- exons 18 to 21 -RRB- and EML4-ALK rearrangement are clinically important markers able to select NSCLC patients which benefit from EGFR or ALK tyrosine kinase inhibitors -LRB- gefitinib , erlotinib , crizotinib -RRB- .
23748900	0	gefitinib	126,135	EGFR	68,72	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	induced|nmod|START_ENTITY dimers|acl|induced dimers|amod|END_ENTITY	Significant increase in hEGF uptake is correlated with formation of EGFR dimers induced by the EGFR tyrosine kinase inhibitor gefitinib .
23780873	0	gefitinib	101,110	EGFR	0,4	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	predict|advcl|START_ENTITY predict|nsubj|mutations mutations|amod|END_ENTITY	EGFR mutations detected on cytology samples by a centralized laboratory reliably predict response to gefitinib in non-small_cell_lung_carcinoma patients .
23809059	0	gefitinib	27,36	EGFR	100,104	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	efficacy|amod|START_ENTITY Impact|nmod|efficacy Impact|nmod|patients patients|nmod|mutations mutations|compound|END_ENTITY	Impact of physical size on gefitinib efficacy in patients with non-small_cell_lung_cancer harboring EGFR mutations .
23852504	0	gefitinib	68,77	EGFR	52,56	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Tumor reoxygenation following administration of the EGFR inhibitor , gefitinib , in experimental tumors .
23986053	0	gefitinib	111,120	EGFR	66,70	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	-RSB-|amod|START_ENTITY erlotinib|nmod|-RSB- having|advcl|erlotinib END_ENTITY|acl|having	-LSB- A case of lung_adenocarcinoma wtih exon19 and T790M mutations in EGFR having good response to erlotinib after gefitinib treatment failure -RSB- .
24055492	0	gefitinib	209,218	EGFR	43,47	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	presence|nmod|START_ENTITY harboring|nmod|presence cells|acl|harboring chemo-refractoriness|nmod|cells epidermal_growth_factor_receptor|dep|chemo-refractoriness epidermal_growth_factor_receptor|appos|END_ENTITY	Combined epidermal_growth_factor_receptor -LRB- EGFR -RRB- - tyrosine kinase inhibitor and chemotherapy in non-small-cell_lung_cancer : chemo-refractoriness of cells harboring sensitizing-EGFR_mutations in the presence of gefitinib .
24198203	0	gefitinib	92,101	EGFR	157,161	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	associated|nmod|START_ENTITY associated|nmod|mutation mutation|amod|END_ENTITY	microRNA expression profiles associated with survival , disease progression , and response to gefitinib in completely resected non-small-cell_lung_cancer with EGFR mutation .
24263064	0	gefitinib	11,20	EGFR	34,38	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	START_ENTITY|nmod|patients patients|compound|END_ENTITY	First-line gefitinib in Caucasian EGFR mutation-positive NSCLC patients : a phase-IV , open-label , single-arm study .
24362878	0	gefitinib	113,122	EGFR	73,77	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	mutated|nmod|START_ENTITY mutated|nsubj|resection resection|nmod|epidermal_growth_factor_receptor epidermal_growth_factor_receptor|appos|END_ENTITY	Surgical resection of locally advanced epidermal_growth_factor_receptor -LRB- EGFR -RRB- mutated lung_adenocarcinoma after gefitinib and review of the literature .
24419415	0	gefitinib	17,26	EGFR	80,84	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	Effectiveness|nmod|START_ENTITY Effectiveness|nmod|G719X G719X|compound|END_ENTITY	Effectiveness of gefitinib against non-small-cell_lung_cancer with the uncommon EGFR mutations G719X and L861Q .
24419417	0	gefitinib	156,165	EGFR	93,97	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|outcome outcome|acl|assessed assessed|nmod|response response|nmod|patients patients|nmod|non-small-cell_lung_cancer non-small-cell_lung_cancer|amod|END_ENTITY	Survival outcome assessed according to tumor response and shrinkage pattern in patients with EGFR mutation-positive non-small-cell_lung_cancer treated with gefitinib or erlotinib .
24583857	0	gefitinib	14,23	EGFR	69,73	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	sensitivity|amod|START_ENTITY Monitoring|nmod|sensitivity based|nsubj|Monitoring based|nmod|expression expression|amod|END_ENTITY	Monitoring of gefitinib sensitivity with radioiodinated PHY based on EGFR expression .
24585406	0	gefitinib	61,70	EGFR	135,139	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	mutations|amod|START_ENTITY mutations|compound|END_ENTITY	Pemetrexed-carboplatin adjuvant chemotherapy with or without gefitinib in resected stage IIIA-N2 non-small_cell_lung_cancer harbouring EGFR mutations : a randomized , phase II study .
24586426	0	gefitinib	33,42	EGFR	115,119	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	START_ENTITY|nmod|non-small-cell_lung_cancer non-small-cell_lung_cancer|nmod|mutations mutations|compound|END_ENTITY	Economic outcomes of maintenance gefitinib for locally advanced/metastatic non-small-cell_lung_cancer with unknown EGFR mutations : a semi-Markov model analysis .
24854557	0	gefitinib	13,22	EGFR	55,59	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	Efficacy|nmod|START_ENTITY Efficacy|nmod|mutation mutation|amod|END_ENTITY	-LSB- Efficacy of gefitinib for young patients with unknown EGFR gene mutation in advanced lung_adenocarcinoma -RSB- .
24928833	0	gefitinib	139,148	EGFR	111,115	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	treated|nmod|START_ENTITY SNPs|acl|treated SNPs|nmod|mutations mutations|amod|END_ENTITY	SNPs in the transforming_growth_factor-b pathway as predictors of outcome in advanced lung_adenocarcinoma with EGFR mutations treated with gefitinib .
24983493	0	gefitinib	36,45	EGFR	60,64	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	resistance|compound|START_ENTITY resistance|nmod|cells cells|amod|END_ENTITY	MicroRNA-34a overcomes HGF-mediated gefitinib resistance in EGFR mutant lung_cancer cells partly by targeting MET .
25070024	0	gefitinib	72,81	EGFR	41,45	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	responsive|xcomp|START_ENTITY responsive|nsubj|line line|nmod|END_ENTITY	Esophageal_carcinoma cell line with high EGFR polysomy is responsive to gefitinib .
25087097	0	gefitinib	11,20	EGFR	92,96	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	therapy|compound|START_ENTITY therapy|nmod|patients patients|nmod|lung_cancer lung_cancer|acl|harboring harboring|dobj|mutation mutation|amod|END_ENTITY	First-line gefitinib therapy for elderly patients with non-small cell lung_cancer harboring EGFR mutation : Central Japan Lung Study Group 0901 .
25120716	0	gefitinib	17,26	EGFR	47,51	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	START_ENTITY|nmod|treatment treatment|nmod|END_ENTITY	High efficacy of gefitinib in the treatment of EGFR mutation-positive advanced non-small_cell_lung_adenocarcinoma : A case report .
25173459	0	gefitinib	14,23	EGFR	121,125	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	Evaluation|nmod|START_ENTITY efficacy|nsubj|Evaluation efficacy|nmod|non-small_cell_lung_cancer non-small_cell_lung_cancer|acl|harboring harboring|dobj|mutation mutation|amod|END_ENTITY	Evaluation of gefitinib efficacy according to body surface area in patients with non-small_cell_lung_cancer harboring an EGFR mutation .
25353970	0	gefitinib	24,33	EGFR	101,105	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	exposure|nmod|START_ENTITY induces|nsubj|exposure induces|nmod|changes changes|nmod|END_ENTITY	Long - term exposure to gefitinib induces acquired resistance through DNA methylation changes in the EGFR - mutant PC9_lung_cancer cell line .
25546556	8	gefitinib	1664,1673	EGFR	1593,1597	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	biomarker|nmod|START_ENTITY biomarker|nsubj|mutation mutation|compound|END_ENTITY	CONCLUSION : : EGFR mutation was the strongest predictive biomarker for OS benefit of gefitinib as maintenance treatment .
25653196	0	gefitinib	98,107	EGFR	47,51	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	pathway|nmod|START_ENTITY recycling|nmod|pathway recycling|amod|END_ENTITY	EGF - stimulated AKT activation is mediated by EGFR recycling via an early endocytic pathway in a gefitinib - resistant human lung_cancer cell line .
25669832	0	gefitinib	70,79	EGFR	163,167	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	alternating|dobj|START_ENTITY alternating|nmod|non-small_cell_lung_cancer non-small_cell_lung_cancer|nmod|mutations mutations|compound|END_ENTITY	Randomized phase II study of concurrent versus sequential alternating gefitinib and chemotherapy in previously untreated non-small_cell_lung_cancer with sensitive EGFR mutations : NEJ005/TCOG0902 .
25788032	0	gefitinib	31,40	EGFR	74,78	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	sensitivity|amod|START_ENTITY increases|dobj|sensitivity increases|nmod|inhibition inhibition|nmod|endocytosis endocytosis|amod|END_ENTITY	Galectin-3 knockdown increases gefitinib sensitivity to the inhibition of EGFR endocytosis in gefitinib-insensitive esophageal squamous cancer cells .
25877748	0	gefitinib	171,180	EGFR	63,67	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	comparing|dobj|START_ENTITY study|acl|comparing advanced|nmod|study advanced|nsubj|Efficacy Efficacy|nmod|chemotherapy chemotherapy|nmod|therapy therapy|nmod|mutation-positive mutation-positive|amod|END_ENTITY	Efficacy of chemotherapy after first-line gefitinib therapy in EGFR mutation-positive advanced non-small_cell_lung_cancer-data from a randomized Phase III study comparing gefitinib with carboplatin plus paclitaxel -LRB- NEJ002 -RRB- .
25877748	0	gefitinib	42,51	EGFR	63,67	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	therapy|compound|START_ENTITY therapy|nmod|mutation-positive mutation-positive|amod|END_ENTITY	Efficacy of chemotherapy after first-line gefitinib therapy in EGFR mutation-positive advanced non-small_cell_lung_cancer-data from a randomized Phase III study comparing gefitinib with carboplatin plus paclitaxel -LRB- NEJ002 -RRB- .
25886066	0	gefitinib	93,102	EGFR	141,145	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|lung_adenocarcinoma lung_adenocarcinoma|nmod|mutation mutation|amod|END_ENTITY	MET FISH-positive status predicts short progression-free survival and overall_survival after gefitinib treatment in lung_adenocarcinoma with EGFR mutation .
25903122	0	gefitinib	20,29	EGFR	131,135	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	monotherapy|amod|START_ENTITY harboring|nsubj|monotherapy harboring|advcl|activating activating|dobj|mutations mutations|amod|END_ENTITY	A phase II trial of gefitinib monotherapy in pretreated patients with advanced non-small_cell_lung_cancer not harboring activating EGFR mutations : implications of sensitive EGFR mutation test .
25903122	0	gefitinib	20,29	EGFR	173,177	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	monotherapy|amod|START_ENTITY harboring|nsubj|monotherapy trial|acl|harboring trial|dep|implications implications|nmod|test test|compound|END_ENTITY	A phase II trial of gefitinib monotherapy in pretreated patients with advanced non-small_cell_lung_cancer not harboring activating EGFR mutations : implications of sensitive EGFR mutation test .
25904052	0	gefitinib	81,90	EGFR	94,98	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	START_ENTITY|nmod|lung_adenocarcinoma lung_adenocarcinoma|amod|END_ENTITY	Molecular heterogeneity assessment by next-generation sequencing and response to gefitinib of EGFR mutant advanced lung_adenocarcinoma .
25990507	0	gefitinib	63,72	EGFR	142,146	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	treatment|compound|START_ENTITY harboring|nsubj|treatment harboring|dobj|mutations mutations|compound|END_ENTITY	Efficacy of platinum combination chemotherapy after first-line gefitinib treatment in non-small_cell_lung_cancer patients harboring sensitive EGFR mutations .
25990507	0	gefitinib	63,72	EGFR	142,146	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	treatment|compound|START_ENTITY harboring|nsubj|treatment harboring|dobj|mutations mutations|compound|END_ENTITY	Efficacy of platinum combination chemotherapy after first-line gefitinib treatment in non-small_cell_lung_cancer patients harboring sensitive EGFR mutations .
26087608	0	gefitinib	29,38	EGFR	107,111	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	use|nmod|START_ENTITY experience|nmod|use -LSB-|dobj|experience -LSB-|advcl|activating activating|dobj|mutations mutations|amod|END_ENTITY	-LSB- An experience of the use of gefitinib in patients with inoperable nonsquamous_lung_cancer with activating EGFR mutations -RSB- .
26089022	0	gefitinib	42,51	EGFR	134,138	gefitinib	EGFR	MESH:C419708	13649(Tax:10090)	Chemical	Gene	followed|nmod|START_ENTITY vinorelbine|acl|followed use|nmod|vinorelbine enhances|nsubj|use enhances|xcomp|responsive responsive|nmod|inhibitors inhibitors|compound|END_ENTITY	Sequential use of vinorelbine followed by gefitinib enhances the antitumor effect in NSCLC cell lines poorly responsive to reversible EGFR tyrosine kinase inhibitors .
26175938	0	gefitinib	45,54	EGFR	88,92	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	sensitivity|compound|START_ENTITY marker|nmod|sensitivity marker|nmod|status status|amod|END_ENTITY	Circulating miRNAs is a potential marker for gefitinib sensitivity and correlation with EGFR mutational status in human lung cancers .
26254024	0	gefitinib	11,20	EGFR	113,117	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	treatment|compound|START_ENTITY treatment|nmod|mutations mutations|compound|END_ENTITY	First-line gefitinib treatment in elderly patients -LRB- aged > = 75 years -RRB- with non-small_cell_lung_cancer harboring EGFR mutations .
26338546	0	gefitinib	110,119	EGFR	31,35	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	analysis|nmod|START_ENTITY analysis|nmod|testing testing|amod|END_ENTITY	Cost-effectiveness analysis of EGFR mutation testing in patients with non-small_cell_lung_cancer -LRB- NSCLC -RRB- with gefitinib or carboplatin-paclitaxel .
26339441	0	gefitinib	27,36	EGFR	0,4	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	led|xcomp|START_ENTITY led|nsubj|L747P L747P|compound|END_ENTITY	EGFR mutation L747P led to gefitinib resistance and accelerated liver metastases in a Chinese patient with lung_adenocarcinoma .
26469914	2	gefitinib	333,342	EGFR	322,326	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	TKIs|amod|START_ENTITY TKIs|compound|END_ENTITY	The first-generation reversible EGFR TKIs , gefitinib and erlotinib , demonstrated substantial efficacy in the treatment of brain metastases from EGFR-mutated lung_adenocarcinoma .
26557760	0	gefitinib	44,53	EGFR	103,107	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	induced|nmod|START_ENTITY induced|nmod|non-small_cell_lung_cancer non-small_cell_lung_cancer|acl|inhibiting inhibiting|dobj|END_ENTITY	MicroRNA-7 enhances cytotoxicity induced by gefitinib in non-small_cell_lung_cancer via inhibiting the EGFR and IGF1R signalling pathways .
26623063	0	gefitinib	148,157	EGFR	0,4	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	response|nmod|START_ENTITY Correlation|nmod|response mutations|dep|Correlation mutations|compound|END_ENTITY	EGFR and K-RAS mutations and ERCC1 , TUBB3 , TYMS , RRM1 and EGFR mRNA expression in non-small_cell_lung_cancer : Correlation with clinical response to gefitinib or chemotherapy .
26718140	0	gefitinib	183,192	EGFR	159,163	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	failure|amod|START_ENTITY mutation|nmod|failure mutation|compound|END_ENTITY	Diagnostic significance of cerebrospinal fluid EGFR mutation analysis for leptomeningeal_metastasis in non-small-cell lung_cancer patients harboring an active EGFR mutation following gefitinib therapy failure .
26718140	0	gefitinib	183,192	EGFR	47,51	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	failure|amod|START_ENTITY mutation|nmod|failure harboring|dobj|mutation significance|acl|harboring significance|nmod|analysis analysis|compound|END_ENTITY	Diagnostic significance of cerebrospinal fluid EGFR mutation analysis for leptomeningeal_metastasis in non-small-cell lung_cancer patients harboring an active EGFR mutation following gefitinib therapy failure .
26724810	0	gefitinib	114,123	EGFR	86,90	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	treated|nmod|START_ENTITY mutations|acl|treated mutations|amod|END_ENTITY	Total regression of brain metastases in non-small cell lung_cancer patients harboring EGFR mutations treated with gefitinib without radiotherapy : two case reports .
26898617	0	gefitinib	81,90	EGFR	108,112	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|mutation mutation|amod|END_ENTITY	Association of pharmacokinetics and pharmacogenomics with safety and efficacy of gefitinib in patients with EGFR mutation positive advanced non-small_cell_lung_cancer .
27051298	0	gefitinib	216,225	EGFR	117,121	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	treatment|compound|START_ENTITY developing|nmod|treatment receiving|advcl|developing mutations|acl|receiving mutations|compound|END_ENTITY	Pemetrexed had significantly better clinical efficacy in patients with stage_IV_lung_adenocarcinoma with susceptible EGFR mutations receiving platinum-based chemotherapy after developing resistance to the first-line gefitinib treatment .
27091996	0	gefitinib	76,85	EGFR	50,54	gefitinib	EGFR	MESH:C419708	1956	Chemical	Gene	resistance|compound|START_ENTITY resistance|amod|END_ENTITY	NF-kB-driven suppression of FOXO3a contributes to EGFR mutation-independent gefitinib resistance .
26342551	0	gefitinib	49,58	EI24	22,26	gefitinib	EI24	MESH:C419708	9538	Chemical	Gene	confers|advcl|START_ENTITY confers|nsubj|expression expression|nmod|END_ENTITY	Reduced expression of EI24 confers resistance to gefitinib through IGF-1R signaling in PC9 NSCLC cells .
23874590	0	gefitinib	37,46	Egfr	136,140	gefitinib	Egfr	MESH:C419708	1956	Chemical	Gene	irradiation|amod|START_ENTITY effect|nmod|irradiation predicted|nsubjpass|effect predicted|nmod|activity activity|compound|END_ENTITY	Synergistic antitumor effect between gefitinib and fractionated irradiation in anaplastic_oligodendrogliomas can not be predicted by the Egfr signaling activity .
15386420	0	gefitinib	96,105	Epidermal_growth_factor_receptor	0,32	gefitinib	Epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	markers|nmod|START_ENTITY END_ENTITY|nmod|markers	Epidermal_growth_factor_receptor -LRB- EGFR -RRB- downstream molecules as response predictive markers for gefitinib -LRB- Iressa , ZD1839 -RRB- in chemotherapy-resistant non-small_cell_lung_cancer .
15998907	0	gefitinib	83,92	Epidermal_growth_factor_receptor	0,32	gefitinib	Epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	sensitivity|amod|START_ENTITY predict|dobj|sensitivity predict|nsubj|mutations mutations|amod|END_ENTITY	Epidermal_growth_factor_receptor gene mutations and increased copy numbers predict gefitinib sensitivity in patients with recurrent non-small-cell_lung_cancer .
16152581	0	gefitinib	99,108	Epidermal_growth_factor_receptor	0,32	gefitinib	Epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	predict|advcl|START_ENTITY predict|nsubj|mutations mutations|amod|END_ENTITY	Epidermal_growth_factor_receptor mutations in needle biopsy/aspiration samples predict response to gefitinib therapy and survival of patients with advanced nonsmall_cell_lung_cancer .
16198442	0	gefitinib	63,72	Epidermal_growth_factor_receptor	0,32	gefitinib	Epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	sensitivity|amod|START_ENTITY associated|nmod|sensitivity associated|nsubjpass|mutations mutations|compound|END_ENTITY	Epidermal_growth_factor_receptor mutations are associated with gefitinib sensitivity in non-small_cell_lung_cancer in Japanese .
16204011	0	gefitinib	136,145	Epidermal_growth_factor_receptor	0,32	gefitinib	Epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	trials|amod|START_ENTITY analysis|nmod|trials mutations|dep|analysis mutations|amod|END_ENTITY	Epidermal_growth_factor_receptor mutations and gene amplification in non-small-cell lung_cancer : molecular analysis of the IDEAL/INTACT gefitinib trials .
16243822	0	gefitinib	92,101	Epidermal_growth_factor_receptor	0,32	gefitinib	Epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	determines|xcomp|START_ENTITY determines|nsubj|activity activity|amod|END_ENTITY	Epidermal_growth_factor_receptor activity determines response of colorectal_cancer cells to gefitinib alone and in combination with chemotherapy .
16556022	0	gefitinib	66,75	Epidermal_growth_factor_receptor	0,32	gefitinib	Epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	predict|advcl|START_ENTITY predict|nsubj|mutations mutations|compound|END_ENTITY	Epidermal_growth_factor_receptor mutations predict sensitivity to gefitinib in patients with non-small-cell lung_cancer .
16635086	0	gefitinib	55,64	Epidermal_growth_factor_receptor	0,32	gefitinib	Epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	targeted|nmod|START_ENTITY targeted|nsubj|END_ENTITY	Epidermal_growth_factor_receptor targeted therapy with gefitinib in locally advanced and metastatic primary lung_adenocarcinoma .
17375033	0	gefitinib	121,130	Epidermal_growth_factor_receptor	0,32	gefitinib	Epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|polymorphisms polymorphisms|amod|END_ENTITY	Epidermal_growth_factor_receptor polymorphisms and clinical outcomes in non-small-cell_lung_cancer patients treated with gefitinib .
17875767	0	gefitinib	175,184	Epidermal_growth_factor_receptor	0,32	gefitinib	Epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	treated|nmod|START_ENTITY non_small_cell_lung_cancer|acl|treated patients|nmod|non_small_cell_lung_cancer outcomes|nmod|patients predicts|dobj|outcomes predicts|nsubj|detection detection|amod|END_ENTITY	Epidermal_growth_factor_receptor mutation detection using high-resolution melting analysis predicts outcomes in patients with advanced non_small_cell_lung_cancer treated with gefitinib .
18219661	0	gefitinib	122,131	Epidermal_growth_factor_receptor	0,32	gefitinib	Epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	predict|nmod|START_ENTITY comparison|acl|predict immunohistochemistry|dep|comparison immunohistochemistry|amod|END_ENTITY	Epidermal_growth_factor_receptor immunohistochemistry : comparison of antibodies and cutoff points to predict benefit from gefitinib in a phase 3 placebo-controlled study in advanced nonsmall-cell_lung_cancer .
18327586	0	gefitinib	145,154	Epidermal_growth_factor_receptor	0,32	gefitinib	Epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	treated|nmod|START_ENTITY colorectal_cancer|acl|treated predict|nmod|colorectal_cancer predict|nsubj|level level|compound|END_ENTITY	Epidermal_growth_factor_receptor serum -LRB- sEGFR -RRB- level may predict response in patients with EGFR-positive advanced colorectal_cancer treated with gefitinib ?
18787840	0	gefitinib	138,147	Epidermal_growth_factor_receptor	0,32	gefitinib	Epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|analysis analysis|amod|END_ENTITY	Epidermal_growth_factor_receptor expression analysis in chemotherapy-naive patients with advanced non-small-cell_lung_cancer treated with gefitinib or placebo in combination with platinum-based chemotherapy .
18827605	0	gefitinib	64,73	Epidermal_growth_factor_receptor	0,32	gefitinib	Epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	outcome|amod|START_ENTITY predicts|dobj|outcome predicts|nsubj|polymorphism polymorphism|amod|END_ENTITY	Epidermal_growth_factor_receptor intron-1 polymorphism predicts gefitinib outcome in advanced non-small_cell_lung_cancer .
21333004	0	gefitinib	88,97	Epidermal_growth_factor_receptor	0,32	gefitinib	Epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	sensitivity|amod|START_ENTITY alters|dobj|sensitivity alters|nsubj|mutation mutation|amod|END_ENTITY	Epidermal_growth_factor_receptor mutation in combination with expression of MIG6 alters gefitinib sensitivity .
21900837	0	gefitinib	116,125	Epidermal_growth_factor_receptor	0,32	gefitinib	Epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	study|nmod|START_ENTITY IPASS|appos|study circulating|nmod|IPASS END_ENTITY|advcl|circulating	Epidermal_growth_factor_receptor mutation status in circulating free DNA in serum : from IPASS , a phase III study of gefitinib or carboplatin/paclitaxel in non-small_cell_lung_cancer .
26157326	0	gefitinib	98,107	Epidermal_growth_factor_receptor	0,32	gefitinib	Epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	analysis|acl|START_ENTITY analysis|amod|END_ENTITY	Epidermal_growth_factor_receptor mutation analysis in cytological specimens and responsiveness to gefitinib in advanced non-small_cell_lung_cancer patients .
18089711	0	gefitinib	64,73	FOXO3a	25,31	gefitinib	FOXO3a	MESH:C419708	2309	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	The transcription factor FOXO3a is a crucial cellular target of gefitinib -LRB- Iressa -RRB- in breast_cancer cells .
22447226	0	gefitinib	29,38	FoxM1	0,5	gefitinib	FoxM1	MESH:C419708	2305	Chemical	Gene	mediated|nmod|START_ENTITY mediated|nsubj|END_ENTITY	FoxM1 mediated resistance to gefitinib in non-small-cell_lung_cancer cells .
18448563	0	gefitinib	20,29	HER-1	57,62	gefitinib	HER-1	MESH:C419708	1956	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	A phase II study of gefitinib for patients with advanced HER-1 expressing synovial_sarcoma refractory to doxorubicin-containing regimens .
22855581	0	gefitinib	23,32	IGF1R	44,49	gefitinib	IGF1R	MESH:C419708	3480	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Contrasted outcomes to gefitinib on tumoral IGF1R expression in head_and_neck_cancer patients receiving_postoperative_chemoradiation -LRB- GORTEC trial 2004-02 -RRB- .
21286012	0	gefitinib	65,74	MEK	93,96	gefitinib	MEK	MESH:C419708	5609	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Could HBx protein expression affect signal pathway inhibition by gefitinib or selumetinib , a MEK inhibitor , in hepatocellular_carcinoma cell lines ?
23102728	0	gefitinib	125,134	MEK	0,3	gefitinib	MEK	MESH:C419708	5609	Chemical	Gene	resistance|nmod|START_ENTITY cells|nmod|resistance inhibitors|nmod|cells inhibitors|nsubj|END_ENTITY	MEK inhibitors reverse resistance in epidermal_growth_factor_receptor mutation lung cancer cells with acquired resistance to gefitinib .
26542452	0	gefitinib	28,37	PKM2	8,12	gefitinib	PKM2	MESH:C419708	5315	Chemical	Gene	contributes|xcomp|START_ENTITY contributes|nsubj|END_ENTITY	Nuclear PKM2 contributes to gefitinib resistance via upregulation of STAT3 activation in colorectal_cancer .
14555504	0	gefitinib	14,23	PTEN	107,111	gefitinib	PTEN	MESH:C419708	5728	Chemical	Gene	Resistance|acl|START_ENTITY overcome|nsubjpass|Resistance overcome|nmod|restoration restoration|nmod|function function|compound|END_ENTITY	Resistance to gefitinib in PTEN-null HER-overexpressing tumor cells can be overcome through restoration of PTEN function or pharmacologic modulation of constitutive phosphatidylinositol 3 ' - kinase/Akt pathway signaling .
15870831	0	gefitinib	127,136	PTEN	13,17	gefitinib	PTEN	MESH:C419708	5728	Chemical	Gene	mutation|nmod|START_ENTITY mutation|nsubj|Reduction Reduction|nmod|protein protein|compound|END_ENTITY	Reduction of PTEN protein and loss of epidermal_growth factor receptor gene mutation in lung_cancer with natural resistance to gefitinib -LRB- IRESSA -RRB- .
16386327	0	gefitinib	28,37	PTEN	67,71	gefitinib	PTEN	MESH:C419708	5728	Chemical	Gene	activity|nmod:poss|START_ENTITY increase|dobj|activity increase|nmod|expression expression|compound|END_ENTITY	PPAR-gamma agonist increase gefitinib 's antitumor activity through PTEN expression .
17409929	0	gefitinib	71,80	PTEN	0,4	gefitinib	PTEN	MESH:C419708	5728	Chemical	Gene	treatment|amod|START_ENTITY associated|nmod|treatment associated|nsubjpass|END_ENTITY	PTEN and PIK3CA expression is associated with prolonged survival after gefitinib treatment in EGFR-mutated lung_cancer patients .
19723324	0	gefitinib	23,32	PTEN	36,40	gefitinib	PTEN	MESH:C419708	5728	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	The drug-resistance to gefitinib in PTEN low expression cancer cells is reversed by irradiation in vitro .
22095222	0	gefitinib	96,105	PTEN	0,4	gefitinib	PTEN	MESH:C419708	5728	Chemical	Gene	therapy|amod|START_ENTITY copy|nmod|therapy copy|nsubj|END_ENTITY	PTEN and PIK3CA gene copy numbers and poor outcomes in non-small_cell_lung_cancer patients with gefitinib therapy .
25058005	0	gefitinib	47,56	PTEN	21,25	gefitinib	PTEN	MESH:C419708	5728	Chemical	Gene	resistance|amod|START_ENTITY modulates|dobj|resistance modulates|nsubj|expression expression|compound|END_ENTITY	Alteration in Mir-21 / PTEN expression modulates gefitinib resistance in non-small_cell_lung_cancer .
25638724	0	gefitinib	95,104	PTEN	60,64	gefitinib	PTEN	MESH:C419708	5728	Chemical	Gene	resistance|nmod|START_ENTITY contributes|nmod|resistance contributes|nmod|expression expression|nmod|END_ENTITY	CpG hypermethylation contributes to decreased expression of PTEN during acquired resistance to gefitinib in human lung_cancer cell lines .
26482612	0	gefitinib	80,89	PTEN	21,25	gefitinib	PTEN	MESH:C419708	5728	Chemical	Gene	reduce|advcl|START_ENTITY targets|xcomp|reduce targets|dobj|END_ENTITY	MicroRNA-221 targets PTEN to reduce the sensitivity of cervical_cancer cells to gefitinib through the PI3K/Akt signaling pathway .
21569641	0	gefitinib	45,54	SPC-A1	140,146	gefitinib	SPC-A1	MESH:C419708	27032	Chemical	Gene	-RSB-|amod|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Sequence-dependent effect of docetaxel with gefitinib on the proliferation and signal protein expression of human lung_adenocarcinoma cell SPC-A1 -RSB- .
19414346	1	gefitinib	174,183	breast_cancer_resistance_protein	193,225	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	reverses|nsubj|START_ENTITY reverses|dobj|END_ENTITY	BACKGROUND : It has been previously shown that gefitinib reverses breast_cancer_resistance_protein -LRB- BCRP -RRB- - mediated drug resistance .
17909038	0	gefitinib	192,201	cortactin	23,32	gefitinib	cortactin	MESH:C419708	2017	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|expression expression|nmod|END_ENTITY	Aberrant expression of cortactin in head_and_neck_squamous_cell_carcinoma cells is associated with enhanced cell proliferation and resistance to the epidermal_growth_factor_receptor inhibitor gefitinib .
22111840	0	gefitinib	48,57	cytochrome_P450_1A1	61,80	gefitinib	cytochrome P450 1A1	MESH:C419708	1543	Chemical	Gene	START_ENTITY|nmod|enzyme enzyme|amod|END_ENTITY	Metabolism of the EGFR tyrosin kinase inhibitor gefitinib by cytochrome_P450_1A1 enzyme in EGFR-wild type non small cell lung_cancer cell lines .
12775734	0	gefitinib	78,87	epidermal_growth_factor_receptor	19,51	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	tyrosine|dobj|START_ENTITY tyrosine|nsubj|trial trial|nmod|END_ENTITY	Pilot trial of the epidermal_growth_factor_receptor tyrosine kinase inhibitor gefitinib plus carboplatin and paclitaxel in patients with stage IIIB or IV non-small-cell_lung_cancer .
12796031	0	gefitinib	111,120	epidermal_growth_factor_receptor	52,84	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	tyrosine|dobj|START_ENTITY tyrosine|csubj|Phase Phase|xcomp|trial trial|nmod|END_ENTITY	Phase I pharmacokinetic trial of the selective oral epidermal_growth_factor_receptor tyrosine kinase inhibitor gefitinib -LRB- ` Iressa ' , ZD1839 -RRB- in Japanese patients with solid malignant_tumors .
14570950	0	gefitinib	12,21	epidermal_growth_factor_receptor	43,75	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	kinase|nmod|START_ENTITY kinase|nsubj|inhibitor inhibitor|nmod|tyrosine tyrosine|compound|END_ENTITY	Efficacy of gefitinib , an inhibitor of the epidermal_growth_factor_receptor tyrosine kinase , in symptomatic patients with non-small cell lung_cancer : a randomized trial .
14583782	1	gefitinib	128,137	epidermal_growth_factor_receptor	92,124	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	Targeting|nmod|START_ENTITY Targeting|dobj|END_ENTITY	Targeting the epidermal_growth_factor_receptor by gefitinib -LRB- ZD1839 -RRB- .
14679116	0	gefitinib	34,43	epidermal_growth_factor_receptor	65,97	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	inhibitor|appos|START_ENTITY Activity|nmod|inhibitor Activity|nmod|END_ENTITY	Activity of a specific inhibitor , gefitinib -LRB- Iressa , ZD1839 -RRB- , of epidermal_growth_factor_receptor in refractory_non-small-cell_lung_cancer .
14710235	0	gefitinib	93,102	epidermal_growth_factor_receptor	34,66	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	tyrosine|dobj|START_ENTITY tyrosine|nsubj|effect effect|nmod|END_ENTITY	Additive antitumour effect of the epidermal_growth_factor_receptor tyrosine kinase inhibitor gefitinib -LRB- Iressa , ZD1839 -RRB- and the antioestrogen fulvestrant -LRB- Faslodex , ICI_182 ,780 -RRB- in breast_cancer cells .
14757534	0	gefitinib	70,79	epidermal_growth_factor_receptor	16,48	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	tyrosine_kinase|nmod|START_ENTITY tyrosine_kinase|csubj|Targeting Targeting|dobj|END_ENTITY	` Targeting ' the epidermal_growth_factor_receptor tyrosine_kinase with gefitinib -LRB- Iressa -RRB- in non-small_cell_lung_cancer -LRB- NSCLC -RRB- .
15118073	0	gefitinib	120,129	epidermal_growth_factor_receptor	28,60	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	responsiveness|nmod|START_ENTITY mutations|dep|responsiveness mutations|nmod|END_ENTITY	Activating mutations in the epidermal_growth_factor_receptor underlying responsiveness of non-small-cell_lung_cancer to gefitinib .
15187994	0	gefitinib	95,104	epidermal_growth_factor_receptor	12,44	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	response|nmod|START_ENTITY factor|nmod|response expression|nmod|factor expression|compound|END_ENTITY	Analysis of epidermal_growth_factor_receptor expression as a predictive factor for response to gefitinib -LRB- ` Iressa ' , ZD1839 -RRB- in non-small-cell_lung_cancer .
15269162	0	gefitinib	67,76	epidermal_growth_factor_receptor	22,54	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	MDM2|amod|START_ENTITY Combined|nmod|MDM2 Combined|nmod|END_ENTITY	Combined targeting of epidermal_growth_factor_receptor and MDM2 by gefitinib and antisense MDM2 cooperatively inhibit hormone-independent prostate_cancer .
15269164	0	gefitinib	106,115	epidermal_growth_factor_receptor	47,79	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	tyrosine|dobj|START_ENTITY tyrosine|nsubj|Evaluation Evaluation|nmod|potential potential|nmod|END_ENTITY	Evaluation of the therapeutic potential of the epidermal_growth_factor_receptor tyrosine kinase inhibitor gefitinib in preclinical models of bladder_cancer .
15447984	0	gefitinib	11,20	epidermal_growth_factor_receptor	30,62	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of gefitinib on serum epidermal_growth_factor_receptor and HER2 in patients with advanced non-small_cell_lung_cancer .
15475435	0	gefitinib	129,138	epidermal_growth_factor_receptor	86,118	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	START_ENTITY|amod|vitro vitro|nmod|inhibitor inhibitor|compound|END_ENTITY	Modulation of DNA repair in vitro after treatment with chemotherapeutic agents by the epidermal_growth_factor_receptor inhibitor gefitinib -LRB- ZD1839 -RRB- .
15582135	0	gefitinib	50,59	epidermal_growth_factor_receptor	14,46	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	Targeting|nmod|START_ENTITY Targeting|dobj|END_ENTITY	Targeting the epidermal_growth_factor_receptor by gefitinib for treatment of hepatocellular_carcinoma .
15623594	0	gefitinib	125,134	epidermal_growth_factor_receptor	18,50	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	responsiveness|amod|START_ENTITY related|nmod|responsiveness related|nsubj|frequency frequency|nmod|mutations mutations|compound|END_ENTITY	High frequency of epidermal_growth_factor_receptor mutations with complex patterns in non-small_cell_lung_cancers related to gefitinib responsiveness in Taiwan .
15688060	0	gefitinib	123,132	epidermal_growth_factor_receptor	64,96	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	START_ENTITY|amod|tyrosine tyrosine|amod|END_ENTITY	Ocular findings in patients with solid tumours treated with the epidermal_growth_factor_receptor tyrosine kinase inhibitor gefitinib -LRB- ` Iressa ' , ZD1839 -RRB- in Phase I and II clinical trials .
15710947	0	gefitinib	130,139	epidermal_growth_factor_receptor	36,68	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|impact impact|nmod|mutation mutation|compound|END_ENTITY	Predictive and prognostic impact of epidermal_growth_factor_receptor mutation in non-small-cell_lung_cancer patients treated with gefitinib .
15738541	0	gefitinib	88,97	epidermal_growth_factor_receptor	17,49	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	treatment|amod|START_ENTITY predict|nmod|treatment predict|nsubj|Mutations Mutations|nmod|gene gene|compound|END_ENTITY	Mutations of the epidermal_growth_factor_receptor gene predict prolonged survival after gefitinib treatment in patients with non-small-cell lung_cancer with postoperative recurrence .
15897572	0	gefitinib	117,126	epidermal_growth_factor_receptor	42,74	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	treatment|amod|START_ENTITY factor|nmod|treatment factor|nsubj|Mutation Mutation|nmod|domain domain|nmod|END_ENTITY	Mutation in the tyrosine kinase domain of epidermal_growth_factor_receptor is a predictive and prognostic factor for gefitinib treatment in patients with non-small_cell_lung_cancer .
15899817	0	gefitinib	45,54	epidermal_growth_factor_receptor	59,91	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	HER2 overexpression increases sensitivity to gefitinib , an epidermal_growth_factor_receptor tyrosine kinase inhibitor , through inhibition of HER2/HER3 heterodimer formation in lung_cancer cells .
15998906	0	gefitinib	148,157	epidermal_growth_factor_receptor	10,42	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	detected|xcomp|START_ENTITY number|acl|detected number|compound|END_ENTITY	Increased epidermal_growth_factor_receptor gene copy number detected by fluorescence in situ hybridization associates with increased sensitivity to gefitinib in patients with bronchioloalveolar_carcinoma subtypes : a Southwest Oncology Group Study .
16027522	0	gefitinib	92,101	epidermal_growth_factor_receptor	21,53	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	responsiveness|xcomp|START_ENTITY responsiveness|nsubj|mutations mutations|nmod|END_ENTITY	Somatic mutations in epidermal_growth_factor_receptor underlying complete responsiveness to gefitinib in a Taiwanese female patient with metastatic adenocarcinoma_of_lung .
16061871	0	gefitinib	18,27	epidermal_growth_factor_receptor	126,158	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	study|nmod|START_ENTITY study|nmod|patients patients|nmod|mutations mutations|compound|END_ENTITY	Phase II study of gefitinib in patients with relapsed or persistent ovarian_or_primary_peritoneal_carcinoma and evaluation of epidermal_growth_factor_receptor mutations and immunohistochemical expression : a Gynecologic Oncology Group Study .
16106023	0	gefitinib	24,33	epidermal_growth_factor_receptor	87,119	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|mutations mutations|compound|END_ENTITY	Differential effects of gefitinib and cetuximab on non-small-cell_lung_cancers bearing epidermal_growth_factor_receptor mutations .
16119008	0	gefitinib	49,58	epidermal_growth_factor_receptor	146,178	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	patients|nmod|START_ENTITY Retreatment|nmod|patients Retreatment|acl:relcl|experienced experienced|nmod|inhibitor inhibitor|compound|END_ENTITY	Retreatment of lung adenocarcinoma patients with gefitinib who had experienced favorable results from their initial treatment with this selective epidermal_growth_factor_receptor inhibitor : a report of three cases .
16140420	0	gefitinib	112,121	epidermal_growth_factor_receptor	13,45	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	associated|xcomp|START_ENTITY associated|nsubjpass|Mutations Mutations|nmod|END_ENTITY	Mutations of epidermal_growth_factor_receptor of non-small cell lung_cancer were associated with sensitivity to gefitinib in recurrence after surgery .
16364494	0	gefitinib	183,192	epidermal_growth_factor_receptor	28,60	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	resistance|nmod|START_ENTITY tyrosine|nmod|resistance tyrosine|nsubj|END_ENTITY	EKB-569 , a new irreversible epidermal_growth_factor_receptor tyrosine kinase inhibitor , with clinical activity in patients with non-small_cell_lung_cancer with acquired resistance to gefitinib .
16428508	0	gefitinib	93,102	epidermal_growth_factor_receptor	34,66	gefitinib	epidermal growth factor receptor	MESH:C419708	13649(Tax:10090)	Chemical	Gene	tyrosine|dobj|START_ENTITY tyrosine|nsubj|activity activity|nmod|END_ENTITY	Synergistic antitumor activity of epidermal_growth_factor_receptor tyrosine kinase inhibitor gefitinib and IFN-alpha in head_and_neck_cancer cells in vitro and in vivo .
16503086	0	gefitinib	107,116	epidermal_growth_factor_receptor	21,53	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	Relationship|nmod|START_ENTITY Relationship|nmod|mutations mutations|compound|END_ENTITY	Relationship between epidermal_growth_factor_receptor gene mutations and the severity of adverse events by gefitinib in patients with advanced non-small_cell_lung_cancer .
16507511	0	gefitinib	82,91	epidermal_growth_factor_receptor	96,128	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	metabolite|nmod|START_ENTITY contribution|appos|metabolite contribution|dep|END_ENTITY	Minimal contribution of desmethyl-gefitinib , the major human plasma metabolite of gefitinib , to epidermal_growth_factor_receptor -LRB- EGFR -RRB- - mediated tumour growth inhibition .
16532343	0	gefitinib	29,38	epidermal_growth_factor_receptor	100,132	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	resistance|amod|START_ENTITY induce|dobj|resistance induce|nmod|activation activation|acl|signaling signaling|dobj|downstream downstream|nmod|END_ENTITY	Activated Src and Ras induce gefitinib resistance by activation of signaling pathways downstream of epidermal_growth_factor_receptor in human gallbladder_adenocarcinoma cells .
16585207	0	gefitinib	135,144	epidermal_growth_factor_receptor	64,96	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	constitutive|nmod|START_ENTITY constitutive|dobj|activation activation|amod|END_ENTITY	Transforming_growth_factor_alpha expression drives constitutive epidermal_growth_factor_receptor pathway activation and sensitivity to gefitinib -LRB- Iressa -RRB- in human pancreatic_cancer cell lines .
16619582	0	gefitinib	74,83	epidermal_growth_factor_receptor	113,145	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	response|amod|START_ENTITY predicts|dobj|response predicts|nmod|mutations mutations|compound|END_ENTITY	Diffuse micronodular pulmonary metastasis of lung_adenocarcinoma predicts gefitinib response in association with epidermal_growth_factor_receptor mutations .
16638863	0	gefitinib	38,47	epidermal_growth_factor_receptor	102,134	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	Optimization|nmod|START_ENTITY Optimization|nmod|analysis analysis|nmod|mutation mutation|compound|END_ENTITY	Optimization of patient selection for gefitinib in non-small_cell_lung_cancer by combined analysis of epidermal_growth_factor_receptor mutation , K-ras mutation , and Akt phosphorylation .
16707461	0	gefitinib	164,173	epidermal_growth_factor_receptor	27,59	gefitinib	epidermal growth factor receptor	MESH:C419708	13649(Tax:10090)	Chemical	Gene	inhibition|nmod|START_ENTITY susceptible|xcomp|inhibition cells|acl:relcl|susceptible prerequisite|nmod|cells prerequisite|nsubj|PTEN/Akt PTEN/Akt|acl|signaling signaling|nmod|END_ENTITY	PTEN/Akt signaling through epidermal_growth_factor_receptor is prerequisite for angiogenesis by hepatocellular_carcinoma cells that is susceptible to inhibition by gefitinib .
16785471	0	gefitinib	30,39	epidermal_growth_factor_receptor	118,150	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	study|nmod|START_ENTITY study|nmod|mutations mutations|compound|END_ENTITY	Prospective phase II study of gefitinib for chemotherapy-naive patients with advanced non-small-cell_lung_cancer with epidermal_growth_factor_receptor gene mutations .
16803841	0	gefitinib	23,32	epidermal_growth_factor_receptor	91,123	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	responses|nmod|START_ENTITY responses|acl|coexpressing coexpressing|dobj|genes genes|compound|END_ENTITY	Different responses to gefitinib in lung_adenocarcinoma coexpressing mutant - and wild-type epidermal_growth_factor_receptor genes .
16818686	0	gefitinib	154,163	epidermal_growth_factor_receptor	30,62	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	treated|nmod|START_ENTITY patients|acl|treated survival|nmod|patients associated|nmod|survival associated|nsubjpass|mutations mutations|nmod|END_ENTITY	Exon 19 deletion mutations of epidermal_growth_factor_receptor are associated with prolonged survival in non-small_cell_lung_cancer patients treated with gefitinib or erlotinib .
16818687	0	gefitinib	99,108	epidermal_growth_factor_receptor	13,45	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	response|acl|START_ENTITY Detection|nmod|response Detection|nmod|mutations mutations|compound|END_ENTITY	Detection of epidermal_growth_factor_receptor mutations in serum as a predictor of the response to gefitinib in patients with non-small-cell_lung_cancer .
16865253	0	gefitinib	116,125	epidermal_growth_factor_receptor	18,50	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	therapy|amod|START_ENTITY Evaluation|nmod|therapy Evaluation|nmod|mutation mutation|compound|END_ENTITY	Evaluation of the epidermal_growth_factor_receptor gene mutation and copy number in non-small_cell_lung_cancer with gefitinib therapy .
16870303	0	gefitinib	105,114	epidermal_growth_factor_receptor	29,61	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	treatment|amod|START_ENTITY associated|nmod|treatment associated|nsubj|patterns patterns|nmod|gene gene|compound|END_ENTITY	Complex mutation patterns of epidermal_growth_factor_receptor gene associated with variable responses to gefitinib treatment in patients with non-small_cell_lung_cancer .
16891476	0	gefitinib	14,23	epidermal_growth_factor_receptor	57,89	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	changes|amod|START_ENTITY changes|nmod|END_ENTITY	Assessment of gefitinib - and CI-1040-mediated changes in epidermal_growth_factor_receptor signaling in HuCCT-1 human cholangiocarcinoma by serial fine needle aspiration .
16926628	0	gefitinib	221,230	epidermal_growth_factor_receptor	177,209	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	inhibitors|xcomp|START_ENTITY inhibitors|nsubj|END_ENTITY	Novel targeted approaches to treating biliary_tract_cancer : the dual epidermal_growth_factor_receptor and ErbB-2 tyrosine kinase inhibitor NVP-AEE788 is more efficient than the epidermal_growth_factor_receptor inhibitors gefitinib and erlotinib .
16926628	0	gefitinib	221,230	epidermal_growth_factor_receptor	69,101	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	inhibitors|xcomp|START_ENTITY efficient|advcl|inhibitors efficient|nsubj|END_ENTITY	Novel targeted approaches to treating biliary_tract_cancer : the dual epidermal_growth_factor_receptor and ErbB-2 tyrosine kinase inhibitor NVP-AEE788 is more efficient than the epidermal_growth_factor_receptor inhibitors gefitinib and erlotinib .
17047648	0	gefitinib	20,29	epidermal_growth_factor_receptor	97,129	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	trial|nmod|START_ENTITY trial|nmod|non-small_cell_lung_cancer non-small_cell_lung_cancer|nmod|mutations mutations|compound|END_ENTITY	A phase II trial of gefitinib as first-line therapy for advanced non-small_cell_lung_cancer with epidermal_growth_factor_receptor mutations .
17145836	0	gefitinib	92,101	epidermal_growth_factor_receptor	26,58	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	correlates|nsubj|START_ENTITY tyrosine|ccomp|correlates tyrosine|nsubj|activity activity|nmod|END_ENTITY	Antitumor activity of the epidermal_growth_factor_receptor -LRB- EGFR -RRB- tyrosine kinase inhibitor gefitinib -LRB- ZD1839 , Iressa -RRB- in non-small_cell_lung_cancer cell lines correlates with gene copy number and EGFR mutations but not EGFR protein levels .
17289870	0	gefitinib	53,62	epidermal_growth_factor_receptor	84,116	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	Proteomic|nmod|START_ENTITY tyrosine|advcl|Proteomic tyrosine|nsubj|END_ENTITY	Proteomic signature corresponding to the response to gefitinib -LRB- Iressa , ZD1839 -RRB- , an epidermal_growth_factor_receptor tyrosine kinase inhibitor in lung_adenocarcinoma .
17290443	0	gefitinib	129,138	epidermal_growth_factor_receptor	11,43	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	responding|nmod|START_ENTITY not|xcomp|responding not|nsubj|Absence Absence|nmod|mutations mutations|compound|END_ENTITY	Absence of epidermal_growth_factor_receptor gene mutations in patients with hormone_refractory_prostate_cancer not responding to gefitinib .
17363490	0	gefitinib	81,90	epidermal_growth_factor_receptor	22,54	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	signaling|nmod|START_ENTITY Combined|acl|signaling Combined|nmod|END_ENTITY	Combined targeting of epidermal_growth_factor_receptor and hedgehog signaling by gefitinib and cyclopamine cooperatively improves the cytotoxic effects of docetaxel on metastatic_prostate_cancer cells .
17387741	0	gefitinib	107,116	epidermal_growth_factor_receptor	24,56	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	efficacy|amod|START_ENTITY predictors|nmod|efficacy amplification|nmod|predictors amplification|nsubj|analysis analysis|nmod|mutations mutations|compound|END_ENTITY	Comparative analysis of epidermal_growth_factor_receptor mutations and gene amplification as predictors of gefitinib efficacy in Japanese patients with nonsmall_cell_lung_cancer .
17409827	0	gefitinib	58,67	epidermal_growth_factor_receptor	117,149	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	activity|amod|START_ENTITY analysis|nmod|activity analysis|dep|tell tell|nsubj|mutations mutations|compound|END_ENTITY	Combined analysis of molecular and clinical predictors of gefitinib activity in advanced non-small_cell_lung_cancer : epidermal_growth_factor_receptor mutations do not tell the whole story .
17409886	0	gefitinib	55,64	epidermal_growth_factor_receptor	11,43	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	inhibitors|xcomp|START_ENTITY inhibitors|nsubj|Use Use|nmod|END_ENTITY	Use of the epidermal_growth_factor_receptor inhibitors gefitinib and erlotinib in the treatment of non-small_cell_lung_cancer : a systematic review .
17410005	0	gefitinib	41,50	epidermal_growth_factor_receptor	66,98	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	prediction|nmod|START_ENTITY validation|nmod|prediction sensitivity|nsubj|validation sensitivity|nmod|mutation mutation|compound|END_ENTITY	Prospective validation for prediction of gefitinib sensitivity by epidermal_growth_factor_receptor gene mutation in patients with non-small_cell_lung_cancer .
17508947	0	gefitinib	98,107	epidermal_growth_factor_receptor	15,47	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	Association|acl|START_ENTITY Association|nmod|mutations mutations|compound|END_ENTITY	Association of epidermal_growth_factor_receptor mutations in lung_cancer with chemosensitivity to gefitinib in isolated_cancer cells from Japanese patients .
17548126	0	gefitinib	25,34	epidermal_growth_factor_receptor	92,124	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	treatment|amod|START_ENTITY resection|nmod|treatment resection|nmod|mutation mutation|compound|END_ENTITY	Surgical resection after gefitinib treatment in patients with lung_adenocarcinoma harboring epidermal_growth_factor_receptor gene mutation .
17611677	0	gefitinib	131,140	epidermal_growth_factor_receptor	18,50	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	guides|advcl|START_ENTITY guides|nsubj|Uncoupling Uncoupling|nmod|END_ENTITY	Uncoupling of the epidermal_growth_factor_receptor from downstream signal transduction molecules guides the acquired resistance to gefitinib in prostate_cancer cells .
17699786	0	gefitinib	88,97	epidermal_growth_factor_receptor	13,45	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	T790M|advcl|START_ENTITY T790M|nsubj|Emergence Emergence|nmod|END_ENTITY	Emergence of epidermal_growth_factor_receptor T790M mutation during chronic exposure to gefitinib in a non small cell lung_cancer cell line .
17785573	0	gefitinib	135,144	epidermal_growth_factor_receptor	91,123	gefitinib	epidermal growth factor receptor	MESH:C419708	13649(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	The intestinotrophic peptide , glp-2 , counteracts intestinal atrophy in mice induced by the epidermal_growth_factor_receptor inhibitor , gefitinib .
17848912	0	gefitinib	106,115	epidermal_growth_factor_receptor	14,46	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	mutation|nmod|START_ENTITY mutation|nsubj|Evaluation Evaluation|nmod|END_ENTITY	Evaluation of epidermal_growth_factor_receptor mutation status in serum DNA as a predictor of response to gefitinib -LRB- IRESSA -RRB- .
17959712	0	gefitinib	169,178	epidermal_growth_factor_receptor	107,139	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	pretreatment|amod|START_ENTITY reversal|nmod|pretreatment transactivation|dep|reversal transactivation|compound|END_ENTITY	17beta-estradiol promotes breast_cancer cell proliferation-inducing stromal_cell-derived_factor-1-mediated epidermal_growth_factor_receptor transactivation : reversal by gefitinib pretreatment .
18261621	0	gefitinib	104,113	epidermal_growth_factor_receptor	26,58	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	associated|xcomp|START_ENTITY associated|nsubjpass|status status|nmod|END_ENTITY	Phosphorylation status of epidermal_growth_factor_receptor is closely associated with responsiveness to gefitinib in pulmonary_adenocarcinoma .
18283321	0	gefitinib	42,51	epidermal_growth_factor_receptor	97,129	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	START_ENTITY|nmod|non-small_cell_lung_cancer non-small_cell_lung_cancer|nmod|mutations mutations|compound|END_ENTITY	Multicentre prospective phase II trial of gefitinib for advanced non-small_cell_lung_cancer with epidermal_growth_factor_receptor mutations : results of the West Japan Thoracic Oncology Group trial -LRB- WJTOG0403 -RRB- .
18325048	0	gefitinib	125,134	epidermal_growth_factor_receptor	28,60	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	heterogeneity|nmod|START_ENTITY heterogeneity|nmod|mutations mutations|compound|END_ENTITY	Intratumor heterogeneity of epidermal_growth_factor_receptor mutations in lung_cancer and its correlation to the response to gefitinib .
18497962	0	gefitinib	103,112	epidermal_growth_factor_receptor	13,45	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	indicate|nmod|START_ENTITY indicate|nsubj|Mutations Mutations|nmod|END_ENTITY	Mutations of epidermal_growth_factor_receptor in colon_cancer indicate susceptibility or resistance to gefitinib .
18544565	0	gefitinib	92,101	epidermal_growth_factor_receptor	48,80	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Involvement of Rad51 in cytotoxicity induced by epidermal_growth_factor_receptor inhibitor -LRB- gefitinib , IressaR -RRB- and chemotherapeutic agents in human lung_cancer cells .
18676761	0	gefitinib	92,101	epidermal_growth_factor_receptor	17,49	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	response|compound|START_ENTITY associated|nmod|response associated|nsubjpass|Lung_cancer Lung_cancer|nmod|exon exon|compound|END_ENTITY	Lung_cancer with epidermal_growth_factor_receptor exon 20 mutations is associated with poor gefitinib treatment response .
18803287	0	gefitinib	128,137	epidermal_growth_factor_receptor	48,80	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	display|xcomp|START_ENTITY display|dobj|END_ENTITY	Chemoresistant_tumor cell lines display altered epidermal_growth_factor_receptor and HER3 signaling and enhanced sensitivity to gefitinib .
18992959	0	gefitinib	30,39	epidermal_growth_factor_receptor	75,107	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	study|nmod|START_ENTITY study|nmod|mutations mutations|compound|END_ENTITY	Prospective phase II study of gefitinib in non-small_cell_lung_cancer with epidermal_growth_factor_receptor gene mutations .
19060236	0	gefitinib	17,26	epidermal_growth_factor_receptor	61,93	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	START_ENTITY|nmod|lung_adenocarcinoma lung_adenocarcinoma|nmod|END_ENTITY	Good response to gefitinib in lung_adenocarcinoma of complex epidermal_growth_factor_receptor -LRB- EGFR -RRB- mutations with the classical mutation pattern .
19188161	0	gefitinib	86,95	epidermal_growth_factor_receptor	23,55	gefitinib	epidermal growth factor receptor	MESH:C419708	13649(Tax:10090)	Chemical	Gene	resistance|amod|START_ENTITY overcomes|dobj|resistance overcomes|nsubj|Addition Addition|nmod|S-1 S-1|nmod|gefitinib gefitinib|compound|END_ENTITY	Addition of S-1 to the epidermal_growth_factor_receptor inhibitor gefitinib overcomes gefitinib resistance in non-small_cell_lung_cancer cell lines with MET amplification .
19224850	0	gefitinib	11,20	epidermal_growth_factor_receptor	85,117	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	harboring|nsubj|START_ENTITY harboring|dobj|mutations mutations|compound|END_ENTITY	First-line gefitinib for patients with advanced non-small-cell_lung_cancer harboring epidermal_growth_factor_receptor mutations without indication for chemotherapy .
19318490	0	gefitinib	100,109	epidermal_growth_factor_receptor	24,56	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	correspond|xcomp|START_ENTITY pathways|xcomp|correspond pathways|nsubj|signatures signatures|nmod|signal signal|compound|END_ENTITY	Proteomic signatures of epidermal_growth_factor_receptor and survival signal pathways correspond to gefitinib sensitivity in head_and_neck_cancer .
19342999	0	gefitinib	102,111	epidermal_growth_factor_receptor	42,74	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Enediyne lidamycin enhances the effect of epidermal_growth_factor_receptor tyrosine kinase inhibitor , gefitinib , in epidermoid_carcinoma A431 cells and lung_carcinoma H460 cells .
19530244	0	gefitinib	129,138	epidermal_growth_factor_receptor	13,45	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	response|acl|START_ENTITY Detection|nmod|response Detection|nmod|mutations mutations|compound|END_ENTITY	Detection of epidermal_growth_factor_receptor mutations in plasma by mutant-enriched PCR assay for prediction of the response to gefitinib in patients with non-small-cell_lung_cancer .
19690148	0	gefitinib	27,36	epidermal_growth_factor_receptor	92,124	gefitinib	epidermal growth factor receptor	MESH:C419708	13649(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY tumorigenesis|nsubj|effects tumorigenesis|advcl|activating activating|dobj|transgenic_mice transgenic_mice|compound|END_ENTITY	Chemopreventive effects of gefitinib on nonsmoking-related lung tumorigenesis in activating epidermal_growth_factor_receptor transgenic_mice .
19823028	0	gefitinib	21,30	epidermal_growth_factor_receptor	46,78	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Molecular imaging of gefitinib activity in an epidermal_growth_factor_receptor -LRB- EGFR -RRB- - bearing xenograft model .
20038315	0	gefitinib	172,181	epidermal_growth_factor_receptor	16,48	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	-RSB-|amod|START_ENTITY treated|nmod|-RSB- treated|nsubj|Correlation Correlation|nmod|mutations mutations|compound|END_ENTITY	-LSB- Correlation of epidermal_growth_factor_receptor mutations and HER2/3 protein expression with clinical outcome in advanced non-small_cell_lung_cancer patients treated with gefitinib -RSB- .
20075572	0	gefitinib	12,21	epidermal_growth_factor_receptor	94,126	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	Efficacy of gefitinib for elderly patients with advanced non-small_cell_lung_cancer harboring epidermal_growth_factor_receptor gene mutations : a retrospective analysis .
20155428	0	gefitinib	103,112	epidermal_growth_factor_receptor	14,46	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	treatment|amod|START_ENTITY efficacy|nmod|treatment _|nmod|efficacy _|nsubj|Prediction Prediction|nmod|mutations mutations|compound|END_ENTITY	Prediction of epidermal_growth_factor_receptor mutations in the plasma/pleural _ effusion to efficacy of gefitinib treatment in advanced non-small_cell_lung_cancer .
20552223	0	gefitinib	26,35	epidermal_growth_factor_receptor	62,94	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	efficacy|nmod|START_ENTITY exon|nsubj|efficacy exon|nmod|END_ENTITY	The different efficacy of gefitinib or erlotinib according to epidermal_growth_factor_receptor exon 19 and exon 21 mutations in Korean non-small_cell_lung_cancer patients .
20828860	0	gefitinib	13,22	epidermal_growth_factor_receptor	127,159	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	START_ENTITY|nmod|mutations mutations|nmod|END_ENTITY	Single-agent gefitinib with concurrent radiotherapy for locally advanced non-small_cell_lung_cancer harboring mutations of the epidermal_growth_factor_receptor .
21108889	0	gefitinib	57,66	epidermal_growth_factor_receptor	13,45	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	-LSB- The role of epidermal_growth_factor_receptor inhibitor , gefitinib , in improvement of quality of life of patients with non-small_cell_lung_cancer -RSB- .
21129309	0	gefitinib	120,129	epidermal_growth_factor_receptor	35,67	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	Relationship|acl|START_ENTITY Relationship|nmod|mutations mutations|nmod|END_ENTITY	-LSB- Relationship between mutations of epidermal_growth_factor_receptor in the plasma and pleural_effusion and responses to gefitinib in advanced pretreated non-small_cell_lung_cancer -RSB- .
21181318	0	gefitinib	113,122	epidermal_growth_factor_receptor	17,49	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	treatment|nmod|START_ENTITY Impact|nmod|treatment Mutations|dep|Impact Mutations|nmod|gene gene|compound|END_ENTITY	Mutations in the epidermal_growth_factor_receptor gene in non-small_cell_lung_cancer : Impact on treatment beyond gefitinib and erlotinib .
21272159	0	gefitinib	12,21	epidermal_growth_factor_receptor	91,123	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	Efficacy|nmod|START_ENTITY harboring|dep|Efficacy harboring|dobj|mutations mutations|compound|END_ENTITY	Efficacy of gefitinib for non-adenocarcinoma non-small-cell_lung_cancer patients harboring epidermal_growth_factor_receptor mutations : a pooled analysis of published reports .
21550558	0	gefitinib	22,31	epidermal_growth_factor_receptor	51,83	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	therapy|amod|START_ENTITY therapy|nmod|mutants mutants|compound|END_ENTITY	First - or second-line gefitinib therapy in unknown epidermal_growth_factor_receptor mutants of non-small-cell_lung_cancer patients treated in Taiwan .
21681118	0	gefitinib	9,18	epidermal_growth_factor_receptor	103,135	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	treatment|compound|START_ENTITY treatment|acl|harboring harboring|dobj|mutations mutations|compound|END_ENTITY	Low-dose gefitinib treatment for patients with advanced non-small_cell_lung_cancer harboring sensitive epidermal_growth_factor_receptor mutations .
21741919	0	gefitinib	114,123	epidermal_growth_factor_receptor	40,72	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	promote|nmod|START_ENTITY increases|xcomp|promote increases|dobj|interactions interactions|nmod|END_ENTITY	DARPP-32 increases interactions between epidermal_growth_factor_receptor and ERBB3 to promote tumor resistance to gefitinib .
21792863	0	gefitinib	102,111	epidermal_growth_factor_receptor	22,54	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	Cost-effectiveness|nmod|START_ENTITY Cost-effectiveness|nmod|testing testing|compound|END_ENTITY	Cost-effectiveness of epidermal_growth_factor_receptor mutation testing and first-line treatment with gefitinib for patients with advanced adenocarcinoma_of_the_lung .
21892099	0	gefitinib	196,205	epidermal_growth_factor_receptor	40,72	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	treatment|amod|START_ENTITY determined|nmod|treatment determined|nsubj|Association Association|nmod|expression expression|nmod|protein protein|compound|END_ENTITY	Association of the expression of mutant epidermal_growth_factor_receptor protein as determined with mutation-specific antibodies in non-small_cell_lung_cancer with progression-free survival after gefitinib treatment .
22266356	0	gefitinib	100,109	epidermal_growth_factor_receptor	15,47	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	regulates|advcl|START_ENTITY regulates|nsubj|Sialylation Sialylation|nmod|END_ENTITY	Sialylation of epidermal_growth_factor_receptor regulates receptor activity and chemosensitivity to gefitinib in colon_cancer cells .
22581704	0	gefitinib	124,133	epidermal_growth_factor_receptor	30,62	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	formulation|nmod|START_ENTITY properties|nmod|formulation properties|nmod|inhibitors inhibitors|compound|END_ENTITY	Physicochemical properties of epidermal_growth_factor_receptor inhibitors and development of a nanoliposomal formulation of gefitinib .
22895139	0	gefitinib	11,20	epidermal_growth_factor_receptor	101,133	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	mutations|amod|START_ENTITY mutations|compound|END_ENTITY	First-line gefitinib in patients aged 75 or older with advanced non-small_cell_lung_cancer harboring epidermal_growth_factor_receptor mutations : NEJ 003 study .
22902462	0	gefitinib	89,98	epidermal_growth_factor_receptor	37,69	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	proved|nsubj|START_ENTITY site|acl:relcl|proved site|nmod|mutation mutation|compound|END_ENTITY	-LSB- Cancer of unknown primary site with epidermal_growth_factor_receptor mutation for which gefitinib proved effective -RSB- .
22923287	0	gefitinib	118,127	epidermal_growth_factor_receptor	168,200	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	START_ENTITY|nmod|suppression suppression|nmod|metalloproteinase-2 metalloproteinase-2|compound|END_ENTITY	Epigallocatechin_gallate sensitizes CAL-27 human oral_squamous_cell_carcinoma cells to the anti-metastatic effects of gefitinib -LRB- Iressa -RRB- via synergistic suppression of epidermal_growth_factor_receptor and matrix metalloproteinase-2 .
22978775	0	gefitinib	23,32	epidermal_growth_factor_receptor	108,140	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	START_ENTITY|nmod|non-small-cell_lung_cancer non-small-cell_lung_cancer|advmod|regardless regardless|nmod|mutation mutation|compound|END_ENTITY	Maintenance therapy of gefitinib for non-small-cell_lung_cancer after first-line chemotherapy regardless of epidermal_growth_factor_receptor mutation : a review in Chinese patients .
23102728	0	gefitinib	125,134	epidermal_growth_factor_receptor	37,69	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	resistance|nmod|START_ENTITY cells|nmod|resistance cells|amod|END_ENTITY	MEK inhibitors reverse resistance in epidermal_growth_factor_receptor mutation lung cancer cells with acquired resistance to gefitinib .
23251095	0	gefitinib	186,195	epidermal_growth_factor_receptor	46,78	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|methods methods|acl|detecting detecting|dobj|mutations mutations|compound|END_ENTITY	Comparison of different methods for detecting epidermal_growth_factor_receptor mutations in peripheral blood and tumor tissue of non-small_cell_lung_cancer as a predictor of response to gefitinib .
23313171	0	gefitinib	158,167	epidermal_growth_factor_receptor	103,135	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	receive|xcomp|START_ENTITY mutations|acl:relcl|receive mutations|compound|END_ENTITY	Tumor burden is predictive of survival in patients with non-small-cell_lung_cancer and with activating epidermal_growth_factor_receptor mutations who receive gefitinib .
24055492	0	gefitinib	209,218	epidermal_growth_factor_receptor	9,41	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	presence|nmod|START_ENTITY harboring|nmod|presence cells|acl|harboring chemo-refractoriness|nmod|cells END_ENTITY|dep|chemo-refractoriness	Combined epidermal_growth_factor_receptor -LRB- EGFR -RRB- - tyrosine kinase inhibitor and chemotherapy in non-small-cell_lung_cancer : chemo-refractoriness of cells harboring sensitizing-EGFR_mutations in the presence of gefitinib .
24084529	0	gefitinib	11,20	epidermal_growth_factor_receptor	25,57	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Effects of gefitinib , an epidermal_growth_factor_receptor inhibitor , on human placental cell growth .
24362878	0	gefitinib	113,122	epidermal_growth_factor_receptor	39,71	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	mutated|nmod|START_ENTITY mutated|nsubj|resection resection|nmod|END_ENTITY	Surgical resection of locally advanced epidermal_growth_factor_receptor -LRB- EGFR -RRB- mutated lung_adenocarcinoma after gefitinib and review of the literature .
24736073	0	gefitinib	42,51	epidermal_growth_factor_receptor	128,160	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	treatment|amod|START_ENTITY outcomes|nmod|treatment Comparison|nmod|outcomes harboring|nsubj|Comparison harboring|dobj|mutation mutation|compound|END_ENTITY	Comparison of clinical outcomes following gefitinib and erlotinib treatment in non-small-cell_lung_cancer patients harboring an epidermal_growth_factor_receptor mutation in either exon 19 or 21 .
24840891	0	gefitinib	9,18	epidermal_growth_factor_receptor	70,102	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	overcome|nsubj|START_ENTITY overcome|xcomp|END_ENTITY	Combined gefitinib and pemetrexed overcome the acquired resistance to epidermal_growth_factor_receptor tyrosine kinase inhibitors in non-small_cell_lung_cancer .
25005787	0	gefitinib	4,13	epidermal_growth_factor_receptor	53,85	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	reduction|amod|START_ENTITY reduction|nmod|non-small_cell_lung_cancer non-small_cell_lung_cancer|amod|END_ENTITY	The gefitinib dose reduction on survival outcomes in epidermal_growth_factor_receptor mutant non-small_cell_lung_cancer .
25034225	0	gefitinib	30,39	epidermal_growth_factor_receptor	109,141	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|type type|nmod|mutation mutation|compound|END_ENTITY	Comparison of the efficacy of gefitinib in patients with non-small_cell_lung_cancer according to the type of epidermal_growth_factor_receptor mutation .
25120654	0	gefitinib	115,124	epidermal_growth_factor_receptor	59,91	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	harboring|nmod|START_ENTITY harboring|nmod|END_ENTITY	Lung_adenocarcinoma harboring L858R and T790M mutations in epidermal_growth_factor_receptor , with poor response to gefitinib : A case report .
25199820	0	gefitinib	162,171	epidermal_growth_factor_receptor	87,119	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	harboring|nmod|START_ENTITY harboring|dobj|mutation mutation|compound|END_ENTITY	Melatonin sensitizes H1975 non-small-cell_lung_cancer cells harboring a T790M-targeted epidermal_growth_factor_receptor mutation to the tyrosine kinase inhibitor gefitinib .
25343946	0	gefitinib	14,23	epidermal_growth_factor_receptor	119,151	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	effect|nmod|START_ENTITY recurrent|nsubj|effect recurrent|dobj|mutations mutations|nmod|END_ENTITY	The effect of gefitinib in patients with postoperative recurrent non-small_cell_lung_cancer harboring mutations of the epidermal_growth_factor_receptor .
25483995	0	gefitinib	57,66	epidermal_growth_factor_receptor	126,158	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	resistance|amod|START_ENTITY characteristics|nmod|resistance characteristics|dep|gefinitib-resistant gefinitib-resistant|nmod|mutation mutation|compound|END_ENTITY	Establishment and biological characteristics of acquired gefitinib resistance in cell line NCI-H1975 / gefinitib-resistant with epidermal_growth_factor_receptor T790M mutation .
25873045	0	gefitinib	40,49	epidermal_growth_factor_receptor	103,135	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|mutations mutations|compound|END_ENTITY	Fuzheng Kang ` ai decoction combined with gefitinib in advanced non-small_cell_lung_cancer patients with epidermal_growth_factor_receptor mutations : study protocol for a randomized controlled trial .
25873045	0	gefitinib	40,49	epidermal_growth_factor_receptor	103,135	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|mutations mutations|compound|END_ENTITY	Fuzheng Kang ` ai decoction combined with gefitinib in advanced non-small_cell_lung_cancer patients with epidermal_growth_factor_receptor mutations : study protocol for a randomized controlled trial .
26089730	0	gefitinib	55,64	epidermal_growth_factor_receptor	11,43	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	inhibitors|dobj|START_ENTITY inhibitors|nsubj|Use Use|nmod|END_ENTITY	Use of the epidermal_growth_factor_receptor inhibitors gefitinib , erlotinib , afatinib , dacomitinib , and icotinib in the treatment of non-small-cell_lung_cancer : a systematic review .
26131116	0	gefitinib	88,97	epidermal_growth_factor_receptor	16,48	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	Mutation|nmod|START_ENTITY Mutation|nmod|gene gene|compound|END_ENTITY	Mutation of the epidermal_growth_factor_receptor gene and its impact on the efficacy of gefitinib in advanced non-small cell lung cance .
26273361	0	gefitinib	17,26	epidermal_growth_factor_receptor	67,99	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	START_ENTITY|nmod|mutation mutation|compound|END_ENTITY	Poor response to gefitinib in lung_adenocarcinoma with concomitant epidermal_growth_factor_receptor mutation and anaplastic_lymphoma kinase rearrangement .
26766992	0	gefitinib	59,68	epidermal_growth_factor_receptor	84,116	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	trial|nmod|START_ENTITY trial|nmod|non-small_cell_lung_cancer non-small_cell_lung_cancer|amod|END_ENTITY	Phase II trial of paclitaxel-carboplatin with intercalated gefitinib for untreated , epidermal_growth_factor_receptor gene mutation status unknown non-small_cell_lung_cancer .
26816540	0	gefitinib	87,96	epidermal_growth_factor_receptor	114,146	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	efficacy|nmod|START_ENTITY predicting|dobj|efficacy predicting|nmod|patients patients|nmod|non-small_cell_lung_cancer non-small_cell_lung_cancer|amod|END_ENTITY	Body mass index and exon 19 mutation as factors predicting the therapeutic efficacy of gefitinib in patients with epidermal_growth_factor_receptor mutation-positive non-small_cell_lung_cancer .
26911477	0	gefitinib	19,28	epidermal_growth_factor_receptor	97,129	gefitinib	epidermal growth factor receptor	MESH:C419708	1956	Chemical	Gene	script|nmod|START_ENTITY script|dep|inhibitor inhibitor|nmod|treatment treatment|nmod|mutation mutation|compound|END_ENTITY	Flipped script for gefitinib : A reapproved tyrosine kinase inhibitor for first-line treatment of epidermal_growth_factor_receptor mutation positive metastatic nonsmall_cell_lung_cancer .
21516302	0	gefitinib	122,131	estrogen_receptor	136,153	gefitinib	estrogen receptor	MESH:C419708	2099	Chemical	Gene	START_ENTITY|nmod|breast_cancer breast_cancer|amod|END_ENTITY	Value of post-operative reassessment of estrogen_receptor a expression following neoadjuvant chemotherapy with or without gefitinib for estrogen_receptor negative breast_cancer .
17016657	0	gefitinib	22,31	estrogen_receptor_alpha	91,114	gefitinib	estrogen receptor alpha	MESH:C419708	2099	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|cells cells|amod|END_ENTITY	Cooperative effect of gefitinib and fumitremorgin_c on cell growth and chemosensitivity in estrogen_receptor_alpha negative fulvestrant-resistant MCF-7 cells .
23402326	0	gefitinib	62,71	integrin_beta1	15,29	gefitinib	integrin beta1	MESH:C419708	3688	Chemical	Gene	resistance|amod|START_ENTITY Association|nmod|resistance Association|nmod|END_ENTITY	Association of integrin_beta1 and c-MET in mediating EGFR TKI gefitinib resistance in non-small_cell_lung_cancer .
15949598	0	gefitinib	17,26	mucin	30,35	gefitinib	mucin	MESH:C419708	100508689	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Novel effects of gefitinib on mucin production in bronchioloalveolar_carcinoma ; two case reports .
19036179	0	geldanamycin	78,90	HSP70	27,32	geldanamycin	HSP70	MESH:C001277	15511(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|nmod|mRNA mRNA|compound|END_ENTITY	Differential expression of HSP70 mRNA in the mouse brain after treatment with geldanamycin .
10798494	0	geldanamycin	41,53	HSP90	102,107	geldanamycin	HSP90	MESH:C001277	3320	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|protein protein|appos|END_ENTITY	The decline of porcine sperm motility by geldanamycin , a specific inhibitor of heat-shock protein 90 -LRB- HSP90 -RRB- .
17893518	0	geldanamycin	18,30	HSP90	0,5	geldanamycin	HSP90	MESH:C001277	111042(Tax:10090)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|nummod|END_ENTITY	HSP90 antagonist , geldanamycin , inhibits proliferation , induces apoptosis and blocks migration of rhabdomyosarcoma cells in vitro and seeding into bone marrow in vivo .
9744771	0	geldanamycin	127,139	HSP90	75,80	geldanamycin	HSP90	MESH:C001277	3320	Chemical	Gene	activities|nmod|START_ENTITY benzoquinone_ansamycin|dep|activities benzoquinone_ansamycin|dep|binds binds|nmod|END_ENTITY	The benzoquinone_ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin .
11916974	6	geldanamycin	1070,1082	Hsp90	1099,1104	geldanamycin	Hsp90	MESH:C001277	3320	Chemical	Gene	displace|dobj|START_ENTITY displace|nmod|binding binding|nmod|END_ENTITY	However , unlike Sti1/Hop/p60 , which can displace geldanamycin upon binding to Hsp90 , Cdc37p/p50 -LRB- cdc37 -RRB- forms a stable complex with geldanamycin-bound Hsp90 and may be sequestered in geldanamycin-inhibited Hsp90 complexes in vivo .
15239664	0	geldanamycin	54,66	Hsp90	103,108	geldanamycin	Hsp90	MESH:C001277	3320	Chemical	Gene	derivatives|compound|START_ENTITY class|nmod|derivatives evaluation|nmod|class evaluation|nmod|END_ENTITY	Synthesis and biological evaluation of a new class of geldanamycin derivatives as potent inhibitors of Hsp90 .
15853661	0	geldanamycin	16,28	Hsp90	0,5	geldanamycin	Hsp90	MESH:C001277	3320	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|END_ENTITY	Hsp90 inhibitor geldanamycin and its derivatives as novel cancer chemotherapeutic agents .
16610363	0	geldanamycin	44,56	Hsp90	23,28	geldanamycin	Hsp90	MESH:C001277	3320	Chemical	Gene	target|nmod|START_ENTITY END_ENTITY|nmod|target	Chaperoning oncogenes : Hsp90 as a target of geldanamycin .
16684877	0	geldanamycin	106,118	Hsp90	54,59	geldanamycin	Hsp90	MESH:C001277	3320	Chemical	Gene	inhibition|nmod|START_ENTITY rationale|dep|inhibition rationale|nmod|effects effects|nmod|inhibitors inhibitors|amod|END_ENTITY	A biochemical rationale for the anticancer effects of Hsp90 inhibitors : slow , tight binding inhibition by geldanamycin and its analogues .
17610208	0	geldanamycin	54,66	Hsp90	37,42	geldanamycin	Hsp90	MESH:C001277	3320	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Proteome-wide changes induced by the Hsp90 inhibitor , geldanamycin in anaplastic_large_cell_lymphoma cells .
18243703	0	geldanamycin	66,78	Hsp90	84,89	geldanamycin	Hsp90	MESH:C001277	3320	Chemical	Gene	derivatives|nmod|START_ENTITY significance|appos|derivatives significance|nmod|activity activity|amod|END_ENTITY	Conformational significance of EH21A1-A4 , phenolic derivatives of geldanamycin , for Hsp90 inhibitory activity .
21778327	0	geldanamycin	67,79	Hsp90	157,162	geldanamycin	Hsp90	MESH:C001277	855836(Tax:4932)	Chemical	Gene	resistance|compound|START_ENTITY arise|nsubj|resistance arise|nmod|pocket pocket|nmod|END_ENTITY	Features of the Streptomyces_hygroscopicus HtpG reveal how partial geldanamycin resistance can arise with mutation to the ATP binding pocket of a eukaryotic Hsp90 .
22825378	0	geldanamycin	33,45	Hsp90	119,124	geldanamycin	Hsp90	MESH:C001277	3320	Chemical	Gene	derivatives|compound|START_ENTITY leads|nsubj|derivatives leads|nmod|END_ENTITY	Fluorine - and rhenium-containing geldanamycin derivatives as leads for the development of molecular probes for imaging Hsp90 .
23038012	0	geldanamycin	29,41	Hsp90	11,16	geldanamycin	Hsp90	MESH:C001277	299331(Tax:10116)	Chemical	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Effects of Hsp90 inhibitors , geldanamycin and its analog , on ceramide metabolism and cytotoxicity in PC12 cells .
23496136	0	geldanamycin	34,46	Hsp90	82,87	geldanamycin	Hsp90	MESH:C001277	3320	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Learning from nature : advances in geldanamycin - and radicicol-based inhibitors of Hsp90 .
23934201	0	geldanamycin	61,73	Hsp90	33,38	geldanamycin	Hsp90	MESH:C001277	3320	Chemical	Gene	heat-shock-protein|dep|START_ENTITY heat-shock-protein|appos|END_ENTITY	Targeting heat-shock-protein 90 -LRB- Hsp90 -RRB- by natural products : geldanamycin , a show case in cancer therapy .
25813406	0	geldanamycin	17,29	Hsp90	81,86	geldanamycin	Hsp90	MESH:C001277	3320	Chemical	Gene	derivative|compound|START_ENTITY 17-DMCHAG|appos|derivative inhibits|nsubj|17-DMCHAG inhibits|nmod|inhibition inhibition|amod|END_ENTITY	17-DMCHAG , a new geldanamycin derivative , inhibits prostate_cancer cells through Hsp90 inhibition and survivin downregulation .
9672245	0	geldanamycin	107,119	Hsp90	55,60	geldanamycin	Hsp90	MESH:C001277	3320	Chemical	Gene	activities|nmod|START_ENTITY binds|dobj|activities binds|nmod|domain domain|nmod|END_ENTITY	Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin .
17671417	0	geldanamycin	75,87	NFkappaB	35,43	geldanamycin	NFkappaB	MESH:C001277	4790	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Targeting autophagic regulation of NFkappaB in HTLV-I transformed cells by geldanamycin : implications for therapeutic interventions .
17875604	0	geldanamycin	61,73	SLC7A11	30,37	geldanamycin	SLC7A11	MESH:C001277	23657	Chemical	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Cystine-glutamate transporter SLC7A11 mediates resistance to geldanamycin but not to 17 - -LRB- allylamino -RRB- -17 - demethoxygeldanamycin .
15804996	0	geldanamycin	4,16	VEGF	45,49	geldanamycin	VEGF	MESH:C001277	7422	Chemical	Gene	secretion|amod|START_ENTITY secretion|amod|END_ENTITY	The geldanamycin derivative 17-AAG decreases VEGF secretion and leukemia growth support by trisomy 8 myelodysplastic_syndrome bone marrow stromal cells .
7592047	0	geldanamycin	138,150	c-MYC	118,123	geldanamycin	c-MYC	MESH:C001277	4609	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Inhibition of the association with nuclear matrix of pRB , p70 and p40 proteins along with the specific suppression of c-MYC expression by geldanamycin , an inhibitor of Src tyrosine kinase .
9295332	0	geldanamycin	70,82	heat_shock_protein_90	29,50	geldanamycin	heat shock protein 90	MESH:C001277	3320	Chemical	Gene	binds|dobj|START_ENTITY END_ENTITY|acl:relcl|binds	The amino-terminal domain of heat_shock_protein_90 -LRB- hsp90 -RRB- that binds geldanamycin is an ATP/ADP switch domain that regulates hsp90 conformation .
15777846	0	geldanamycin	16,28	hsp70	39,44	geldanamycin	hsp70	MESH:C001277	3308	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|stabilisation stabilisation|amod|END_ENTITY	Hsp90 inhibitor geldanamycin increases hsp70 mRNA stabilisation but fails to activate HSF1 in cells exposed to hydrostatic_pressure .
16966435	0	geldanamycin	127,139	hsp90	107,112	geldanamycin	hsp90	MESH:C001277	3320	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|inhibition inhibition|nsubj|vacuolization vacuolization|nmod|END_ENTITY	Endoplasmic reticulum vacuolization and valosin-containing_protein relocalization result from simultaneous hsp90 inhibition by geldanamycin and proteasome inhibition by velcade .
20409220	0	geldanamycin	30,42	hsp90	14,19	geldanamycin	hsp90	MESH:C001277	3320	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|inhibitor inhibitor|amod|END_ENTITY	Effect of the hsp90 inhibitor geldanamycin on androgen response of prostate_cancer under hypoxic conditions .
9295332	0	geldanamycin	70,82	hsp90	126,131	geldanamycin	hsp90	MESH:C001277	3320	Chemical	Gene	binds|dobj|START_ENTITY heat_shock_protein_90|acl:relcl|binds domain|nmod|heat_shock_protein_90 domain|nsubj|domain domain|acl:relcl|regulates regulates|dobj|conformation conformation|amod|END_ENTITY	The amino-terminal domain of heat_shock_protein_90 -LRB- hsp90 -RRB- that binds geldanamycin is an ATP/ADP switch domain that regulates hsp90 conformation .
9295332	0	geldanamycin	70,82	hsp90	52,57	geldanamycin	hsp90	MESH:C001277	3320	Chemical	Gene	binds|dobj|START_ENTITY heat_shock_protein_90|acl:relcl|binds heat_shock_protein_90|appos|END_ENTITY	The amino-terminal domain of heat_shock_protein_90 -LRB- hsp90 -RRB- that binds geldanamycin is an ATP/ADP switch domain that regulates hsp90 conformation .
12270712	0	gelsolin-polyphosphoinositide	15,44	gelsolin	109,117	gelsolin-polyphosphoinositide	gelsolin	null	2934	Chemical	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	Dissecting the gelsolin-polyphosphoinositide interaction and engineering of a polyphosphoinositide-sensitive gelsolin C-terminal half protein .
27077778	0	gemcitabin	14,24	CHOP	62,66	gemcitabin	CHOP	null	1649	Chemical	Gene	Comparison|nmod|START_ENTITY END_ENTITY|nsubj|Comparison	Comparison of gemcitabin , cisplatin , and dexamethasone -LRB- GDP -RRB- , CHOP , and CHOPE in the first-line treatment of peripheral_T-cell_lymphomas .
20038829	0	gemcitabine	30,41	Akt	84,87	gemcitabine	Akt	MESH:C056507	207	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|role role|nmod|END_ENTITY	Enhanced anticancer effect of gemcitabine by genistein in osteosarcoma : the role of Akt and nuclear factor-kappaB .
22263786	0	gemcitabine	49,60	Akt	109,112	gemcitabine	Akt	MESH:C056507	207	Chemical	Gene	effects|nmod|START_ENTITY potentiates|dobj|effects potentiates|nmod|osteosarcoma osteosarcoma|nmod|downregulation downregulation|nmod|END_ENTITY	Genistein potentiates the anti-cancer effects of gemcitabine in human osteosarcoma via the downregulation of Akt and nuclear factor-kB pathway .
26550150	0	gemcitabine	67,78	Bcl-2	123,128	gemcitabine	Bcl-2	MESH:C056507	596	Chemical	Gene	therapy|amod|START_ENTITY therapy|nmod|END_ENTITY	MicroRNA_192 regulates chemo-resistance of lung_adenocarcinoma for gemcitabine and cisplatin combined therapy by targeting Bcl-2 .
23483975	0	gemcitabine	89,100	CHK1	48,52	gemcitabine	CHK1	MESH:C056507	1111	Chemical	Gene	efficacy|compound|START_ENTITY sensitizer|nmod|efficacy checkpoint_kinase_1|nmod|sensitizer checkpoint_kinase_1|appos|END_ENTITY	A kinome screen identifies checkpoint_kinase_1 -LRB- CHK1 -RRB- as a sensitizer for RRM1-dependent gemcitabine efficacy .
26288133	0	gemcitabine	66,77	CHK1	30,34	gemcitabine	CHK1	MESH:C056507	1111	Chemical	Gene	study|nmod|START_ENTITY study|nmod|LY2603618 LY2603618|appos|inhibitor inhibitor|compound|END_ENTITY	Phase I study of LY2603618 , a CHK1 inhibitor , in combination with gemcitabine in Japanese patients with solid tumors .
26612134	0	gemcitabine	73,84	CHK1	23,27	gemcitabine	CHK1	MESH:C056507	1111	Chemical	Gene	effect|nmod|START_ENTITY enhances|dobj|effect enhances|nsubj|LY2603618 LY2603618|appos|inhibitor inhibitor|compound|END_ENTITY	LY2603618 , a selective CHK1 inhibitor , enhances the anti-tumor effect of gemcitabine in xenograft tumor models .
26890478	0	gemcitabine	16,27	CHK1	50,54	gemcitabine	CHK1	MESH:C056507	1111	Chemical	Gene	chemosensitization|amod|START_ENTITY chemosensitization|nmod|END_ENTITY	Dissociation of gemcitabine chemosensitization by CHK1 inhibition from cell cycle checkpoint abrogation and aberrant mitotic entry .
10697572	0	gemcitabine	22,33	CPT-11	50,56	gemcitabine	CPT-11	MESH:C056507	963084(Tax:115711)	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Synergistic effect of gemcitabine and irinotecan -LRB- CPT-11 -RRB- on breast_and_small_cell_lung_cancer cell lines .
12168889	0	gemcitabine	67,78	CPT-11	39,45	gemcitabine	CPT-11	MESH:C056507	963084(Tax:115711)	Chemical	Gene	combination|nmod|START_ENTITY study|nmod|combination study|appos|END_ENTITY	A dose-escalation study of irinotecan -LRB- CPT-11 -RRB- in combination with gemcitabine in patients with advanced non-small_cell_lung_cancer previously treated with a cisplatin-based front line chemotherapy .
23873850	0	gemcitabine	87,98	ChK1	136,140	gemcitabine	ChK1	MESH:C056507	1111	Chemical	Gene	START_ENTITY|nmod|bioavailable bioavailable|appos|inhibitor inhibitor|amod|END_ENTITY	Combination drug scheduling defines a `` window of opportunity '' for chemopotentiation of gemcitabine by an orally bioavailable , selective ChK1 inhibitor , GNE-900 .
22787433	0	gemcitabine	49,60	Chk1	64,68	gemcitabine	Chk1	MESH:C056507	1111	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|amod|END_ENTITY	Sensitization of pancreatic_cancer stem cells to gemcitabine by Chk1 inhibition .
24359526	0	gemcitabine	39,50	Chk1	58,62	gemcitabine	Chk1	MESH:C056507	1111	Chemical	Gene	START_ENTITY|nmod|MK-8776 MK-8776|amod|END_ENTITY	Sensitization of human cancer cells to gemcitabine by the Chk1 inhibitor MK-8776 : cell cycle perturbation and impact of administration schedule in vitro and in vivo .
14716031	0	gemcitabine	81,92	Death_receptor_5	0,16	gemcitabine	Death receptor 5	MESH:C056507	8795	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Death_receptor_5 and Bcl-2 protein expression as predictors of tumor response to gemcitabine and cisplatin in patients with advanced non-small-cell_lung_cancer .
25224279	0	gemcitabine	54,65	Deoxycytidine_kinase	0,20	gemcitabine	Deoxycytidine kinase	MESH:C056507	1633	Chemical	Gene	underpins|advcl|START_ENTITY underpins|nsubj|expression expression|amod|END_ENTITY	Deoxycytidine_kinase expression underpins response to gemcitabine in bladder_cancer .
23497499	0	gemcitabine	46,57	EMAP	100,104	gemcitabine	EMAP	MESH:C056507	9255	Chemical	Gene	START_ENTITY|nmod|II II|compound|END_ENTITY	Enhancing sorafenib-mediated sensitization to gemcitabine in experimental pancreatic_cancer through EMAP II .
26009400	0	gemcitabine	34,45	Glucagon_like_peptide-1	0,23	gemcitabine	Glucagon like peptide-1	MESH:C056507	2641	Chemical	Gene	START_ENTITY|nsubj|increases increases|amod|END_ENTITY	Glucagon_like_peptide-1 increases gemcitabine cytotoxicity in human pancreatic_cancer stem cells -LRB- PCSC -RRB- .
23741071	0	gemcitabine	110,121	IGF1R	140,145	gemcitabine	IGF1R	MESH:C056507	3480	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Putative predictive biomarkers of survival in patients with metastatic pancreatic_adenocarcinoma treated with gemcitabine and ganitumab , an IGF1R inhibitor .
19738614	0	gemcitabine	38,49	MUC4	63,67	gemcitabine	MUC4	MESH:C056507	4585	Chemical	Gene	resistance|nmod|START_ENTITY resistance|dep|role role|nmod|mucin mucin|compound|END_ENTITY	Pancreatic_cancer cells resistance to gemcitabine : the role of MUC4 mucin .
22580602	0	gemcitabine	24,35	MUC4	4,8	gemcitabine	MUC4	MESH:C056507	4585	Chemical	Gene	resistance|amod|START_ENTITY mediates|dobj|resistance mediates|nsubj|mucin mucin|compound|END_ENTITY	The MUC4 mucin mediates gemcitabine resistance of human pancreatic_cancer cells via the Concentrative Nucleoside Transporter family .
23583440	0	gemcitabine	117,128	Mitogen-activated_protein_kinase_kinase	40,79	gemcitabine	Mitogen-activated protein kinase kinase	MESH:C056507	5609	Chemical	Gene	inhibitor|nmod|START_ENTITY inhibitor|nsubj|END_ENTITY	A phase 1b study of trametinib , an oral Mitogen-activated_protein_kinase_kinase -LRB- MEK -RRB- inhibitor , in combination with gemcitabine in advanced solid tumours .
16341142	0	gemcitabine	72,83	NK4	54,57	gemcitabine	NK4	MESH:C056507	9235	Chemical	Gene	treatment|amod|START_ENTITY END_ENTITY|nmod|treatment	Peritumoral injection of adenovirus vector expressing NK4 combined with gemcitabine treatment suppresses growth and metastasis of human pancreatic_cancer cells implanted orthotopically in nude_mice and prolongs survival .
22489660	0	gemcitabine	38,49	Noxa	0,4	gemcitabine	Noxa	MESH:C056507	5366	Chemical	Gene	effect|nmod|START_ENTITY enhances|dobj|effect enhances|nsubj|END_ENTITY	Noxa enhances the cytotoxic effect of gemcitabine in human ovarian_cancer cells .
26796987	0	gemcitabine	145,156	PARP-1	96,102	gemcitabine	PARP-1	MESH:C056507	142	Chemical	Gene	study|nmod|START_ENTITY study|appos|inhibitor inhibitor|amod|END_ENTITY	An open-label , dose-escalation study to evaluate the safety and pharmacokinetics of CEP-9722 -LRB- a PARP-1 and PARP-2 inhibitor -RRB- in combination with gemcitabine and cisplatin in patients with advanced solid tumors .
16721372	0	gemcitabine	41,52	S-1	23,26	gemcitabine	S-1	MESH:C056507	5707	Chemical	Gene	combined|nmod|START_ENTITY combined|nsubj|trial trial|nmod|END_ENTITY	Phase II trial of oral S-1 combined with gemcitabine in metastatic pancreatic_cancer .
18633236	0	gemcitabine	124,135	S-1	145,148	gemcitabine	S-1	MESH:C056507	5707	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- A case of advanced pancreatic_cancer responding to combination chemotherapy with the individual maximum repeatable dose of gemcitabine and oral S-1 -RSB- .
19151975	0	gemcitabine	42,53	S-1	18,21	gemcitabine	S-1	MESH:C056507	5707	Chemical	Gene	trial|nmod|START_ENTITY trial|nmod|END_ENTITY	Phase II trial of S-1 in combination with gemcitabine for chemo-na ve patients with locally advanced or metastatic pancreatic_cancer .
22237958	0	gemcitabine	40,51	S-1	22,25	gemcitabine	S-1	MESH:C056507	5707	Chemical	Gene	combined|nmod|START_ENTITY combined|nsubj|trial trial|nmod|END_ENTITY	Phase I trial of oral S-1 combined with gemcitabine and cisplatin for advanced biliary_tract_cancer -LRB- KHBO1002 -RRB- .
26685318	0	gemcitabine	85,96	S-1	49,52	gemcitabine	S-1	MESH:C056507	5707	Chemical	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	Phase I clinical trial of oral administration of S-1 in combination with intravenous gemcitabine and cisplatin in patients with advanced biliary_tract_cancer .
22559158	0	gemcitabine	54,65	S-1_and_cisplatin	29,46	gemcitabine	S-1 and cisplatin	MESH:C056507	5707	Chemical	Gene	trial|nmod|START_ENTITY trial|nmod|END_ENTITY	Randomized phase II trial of S-1_and_cisplatin versus gemcitabine and cisplatin in patients with advanced biliary tract adenocarcinoma .
23597452	0	gemcitabine	43,54	S0353	5,10	gemcitabine	S0353	MESH:C056507	1076787(Tax:198215)	Chemical	Gene	trial|nmod|START_ENTITY END_ENTITY|dep|trial	SWOG S0353 : Phase II trial of intravesical gemcitabine in patients with nonmuscle invasive bladder_cancer and recurrence after 2 prior courses of intravesical bacillus Calmette-Gu rin .
26358255	0	gemcitabine	105,116	Secreted_protein_acidic_and_rich_in_cysteine	0,44	gemcitabine	Secreted protein acidic and rich in cysteine	MESH:C056507	6678	Chemical	Gene	enhances|xcomp|START_ENTITY enhances|nsubj|END_ENTITY	Secreted_protein_acidic_and_rich_in_cysteine enhances the chemosensitivity of pancreatic_cancer cells to gemcitabine .
21266529	0	gemcitabine	74,85	Src	21,24	gemcitabine	Src	MESH:C056507	6714	Chemical	Gene	kinase|nmod|START_ENTITY kinase|compound|END_ENTITY	Combined blockade of Src kinase and epidermal_growth_factor_receptor with gemcitabine overcomes STAT3-mediated resistance of inhibition of pancreatic_tumor growth .
26503734	0	gemcitabine	49,60	TGFBI	85,90	gemcitabine	TGFBI	MESH:C056507	21810(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|upregulation upregulation|nmod|END_ENTITY	Knockdown of Cul4A increases chemosensitivity to gemcitabine through upregulation of TGFBI in lung_cancer cells .
16238441	0	gemcitabine	50,61	TP53	75,79	gemcitabine	TP53	MESH:C056507	7157	Chemical	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Unraveling the mechanism of radiosensitization by gemcitabine : the role of TP53 .
24509173	0	gemcitabine	66,77	WT1	18,21	gemcitabine	WT1	MESH:C056507	7490	Chemical	Gene	peptide-based|advcl|START_ENTITY peptide-based|nsubj|gene gene|appos|END_ENTITY	Wilms_tumor gene -LRB- WT1 -RRB- peptide-based cancer vaccine combined with gemcitabine for patients with advanced pancreatic_cancer .
12142097	0	gemcitabine	47,58	dCK	30,33	gemcitabine	dCK	MESH:C056507	39429(Tax:7227)	Chemical	Gene	activity|nmod|START_ENTITY activity|appos|END_ENTITY	Role of deoxycytidine_kinase -LRB- dCK -RRB- activity in gemcitabine 's radioenhancement in mice and human cell lines in vitro .
24403266	0	gemcitabine	145,156	death_receptor_5	107,123	gemcitabine	death receptor 5	MESH:C056507	8795	Chemical	Gene	combination|nmod|START_ENTITY Phase|nmod|combination Phase|dep|targeting targeting|dobj|END_ENTITY	Phase 2 , multicenter , open-label study of tigatuzumab -LRB- CS-1008 -RRB- , a humanized monoclonal antibody targeting death_receptor_5 , in combination with gemcitabine in chemotherapy-naive patients with unresectable or metastatic pancreatic_cancer .
11595723	0	gemcitabine	65,76	deoxycytidine_kinase	84,104	gemcitabine	deoxycytidine kinase	MESH:C056507	1633	Chemical	Gene	deoxycytidine|appos|START_ENTITY uptake|nmod|deoxycytidine uptake|nmod|transfer transfer|amod|END_ENTITY	Tumor uptake and elimination of 2 ' ,2 ' - difluoro-2 ' - deoxycytidine -LRB- gemcitabine -RRB- after deoxycytidine_kinase gene transfer : correlation with in vivo tumor response .
12142097	0	gemcitabine	47,58	deoxycytidine_kinase	8,28	gemcitabine	deoxycytidine kinase	MESH:C056507	13178(Tax:10090)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Role of deoxycytidine_kinase -LRB- dCK -RRB- activity in gemcitabine 's radioenhancement in mice and human cell lines in vitro .
12477049	0	gemcitabine	57,68	deoxycytidine_kinase	13,33	gemcitabine	deoxycytidine kinase	MESH:C056507	13178(Tax:10090)	Chemical	Gene	sensitivity|compound|START_ENTITY predict|nmod|sensitivity predict|nsubj|levels levels|compound|END_ENTITY	Pretreatment deoxycytidine_kinase levels predict in vivo gemcitabine sensitivity .
16133534	0	gemcitabine	76,87	deoxycytidine_kinase	45,65	gemcitabine	deoxycytidine kinase	MESH:C056507	1633	Chemical	Gene	START_ENTITY|nsubj|activation activation|nmod|increases increases|amod|END_ENTITY	Cyclopentenyl_cytosine-induced activation of deoxycytidine_kinase increases gemcitabine anabolism and cytotoxicity in neuroblastoma .
16638857	0	gemcitabine	129,140	deoxycytidine_kinase	46,66	gemcitabine	deoxycytidine kinase	MESH:C056507	1633	Chemical	Gene	resistance|amod|START_ENTITY mechanisms|nmod|resistance relationship|nmod|mechanisms evaluation|dep|relationship evaluation|nmod|END_ENTITY	Immunohistochemical and genetic evaluation of deoxycytidine_kinase in pancreatic_cancer : relationship to molecular mechanisms of gemcitabine resistance and survival .
18188186	0	gemcitabine	124,135	deoxycytidine_kinase	44,64	gemcitabine	deoxycytidine kinase	MESH:C056507	1633	Chemical	Gene	effect|nmod|START_ENTITY enhances|dobj|effect enhances|nsubj|transduction transduction|nmod|gene gene|compound|END_ENTITY	Adenoviral vector transduction of the human deoxycytidine_kinase gene enhances the cytotoxic and radiosensitizing effect of gemcitabine on experimental gliomas .
18751396	0	gemcitabine	72,83	deoxycytidine_kinase	19,39	gemcitabine	deoxycytidine kinase	MESH:C056507	1633	Chemical	Gene	resistance|acl|START_ENTITY enhances|dobj|resistance enhances|nsubj|Down-regulation Down-regulation|nmod|END_ENTITY	Down-regulation of deoxycytidine_kinase enhances acquired resistance to gemcitabine in pancreatic_cancer .
19487279	0	gemcitabine	19,30	deoxycytidine_kinase	133,153	gemcitabine	deoxycytidine kinase	MESH:C056507	1633	Chemical	Gene	efficacy|amod|START_ENTITY HuR|nmod|efficacy role|nmod|HuR role|dep|Up-regulates Up-regulates|dep|expression expression|nmod|END_ENTITY	The role of HuR in gemcitabine efficacy in pancreatic_cancer : HuR Up-regulates the expression of the gemcitabine metabolizing enzyme deoxycytidine_kinase .
20043109	0	gemcitabine	21,32	deoxycytidine_kinase	89,109	gemcitabine	deoxycytidine kinase	MESH:C056507	1633	Chemical	Gene	resistance|nmod|START_ENTITY settled|nsubj|resistance settled|nmod|overexpression overexpression|nmod|END_ENTITY	Is the resistance of gemcitabine for pancreatic_cancer settled only by overexpression of deoxycytidine_kinase ?
21362344	0	gemcitabine	110,121	deoxycytidine_kinase	60,80	gemcitabine	deoxycytidine kinase	MESH:C056507	1633	Chemical	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Relationship between single nucleotide polymorphisms in the deoxycytidine_kinase gene and chemosensitivity of gemcitabine in six pancreatic_cancer cell lines .
21832002	0	gemcitabine	29,40	deoxycytidine_kinase	152,172	gemcitabine	deoxycytidine kinase	MESH:C056507	1633	Chemical	Gene	metabolite|nmod|START_ENTITY modulates|nsubj|metabolite modulates|dobj|rate rate|nmod|transport transport|nmod|END_ENTITY	The deaminated metabolite of gemcitabine , 2 ' ,2 ' - difluorodeoxyuridine , modulates the rate of gemcitabine transport and intracellular phosphorylation via deoxycytidine_kinase .
21832002	0	gemcitabine	92,103	deoxycytidine_kinase	152,172	gemcitabine	deoxycytidine kinase	MESH:C056507	1633	Chemical	Gene	transport|amod|START_ENTITY transport|nmod|END_ENTITY	The deaminated metabolite of gemcitabine , 2 ' ,2 ' - difluorodeoxyuridine , modulates the rate of gemcitabine transport and intracellular phosphorylation via deoxycytidine_kinase .
22132977	0	gemcitabine	65,76	deoxycytidine_kinase	14,34	gemcitabine	deoxycytidine kinase	MESH:C056507	1633	Chemical	Gene	Regulation|acl|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of deoxycytidine_kinase expression and sensitivity to gemcitabine by micro-RNA 330 and promoter methylation in cancer cells .
22419259	0	gemcitabine	74,85	deoxycytidine_kinase	34,54	gemcitabine	deoxycytidine kinase	MESH:C056507	1633	Chemical	Gene	resistance|amod|START_ENTITY key|nmod|resistance key|nsubj|Attenuation Attenuation|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Attenuation of phosphorylation by deoxycytidine_kinase is key to acquired gemcitabine resistance in a pancreatic_cancer cell line : targeted proteomic and metabolomic analyses in PK9 cells .
23035362	0	gemcitabine	144,155	deoxycytidine_kinase	45,65	gemcitabine	deoxycytidine kinase	MESH:C056507	1633	Chemical	Gene	cisplatin|amod|START_ENTITY treated|nmod|cisplatin Lack|acl|treated Lack|nmod|END_ENTITY	Lack of association of genetic variations of deoxycytidine_kinase with toxicity or survival of non-small-cell_lung_cancer patients treated with gemcitabine plus cisplatin .
24972933	0	gemcitabine	137,148	deoxycytidine_kinase	18,38	gemcitabine	deoxycytidine kinase	MESH:C056507	1633	Chemical	Gene	analogs|amod|START_ENTITY cross-resistance|nmod|analogs confers|xcomp|cross-resistance confers|nsubj|Downregulation Downregulation|nmod|END_ENTITY	Downregulation of deoxycytidine_kinase in cytarabine-resistant mantle cell lymphoma cells confers cross-resistance to nucleoside analogs gemcitabine , fludarabine and cladribine , but not to other classes of anti-lymphoma agents .
22258814	0	gemcitabine	42,53	glucose-regulated_protein_78	62,90	gemcitabine	glucose-regulated protein 78	MESH:C056507	3309	Chemical	Gene	efficacy|nmod|START_ENTITY efficacy|nmod|END_ENTITY	Survivin-mediated therapeutic efficacy of gemcitabine through glucose-regulated_protein_78 in hepatocellular_carcinoma .
10517165	0	gemcitabine	41,52	granulocyte_colony-stimulating_factor	80,117	gemcitabine	granulocyte colony-stimulating factor	MESH:C056507	1440	Chemical	Gene	Treatment|nmod|START_ENTITY Treatment|nmod|END_ENTITY	Treatment of advanced_breast_cancer with gemcitabine and vinorelbine plus human granulocyte_colony-stimulating_factor .
21129254	0	gemcitabine	11,22	granulocyte_colony-stimulating_factor_receptor	26,72	gemcitabine	granulocyte colony-stimulating factor receptor	MESH:C056507	1441	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|mRNA mRNA|amod|END_ENTITY	-LSB- Effect of gemcitabine on granulocyte_colony-stimulating_factor_receptor and bcr/abl mRNA in patients with chronic_myeloid_leukemia -RSB- .
12173327	0	gemcitabine	32,43	interleukin-2	81,94	gemcitabine	interleukin-2	MESH:C056507	3558	Chemical	Gene	trial|nmod|START_ENTITY trial|nmod|END_ENTITY	A phase II trial of intravenous gemcitabine and 5-fluorouracil with subcutaneous interleukin-2 and interferon-alpha in patients with metastatic_renal_cell_carcinoma .
24940696	0	gemcitabine	18,29	miR-211	0,7	gemcitabine	miR-211	MESH:C056507	406993	Chemical	Gene	START_ENTITY|nsubj|modulates modulates|amod|END_ENTITY	miR-211 modulates gemcitabine activity through downregulation of ribonucleotide reductase and inhibits the invasive behavior of pancreatic_cancer cells .
26684804	0	gemcitabine	118,129	pancreatic_adenocarcinoma_upregulated_factor	10,54	gemcitabine	pancreatic adenocarcinoma upregulated factor	MESH:C056507	124220	Chemical	Gene	increases|xcomp|START_ENTITY increases|nsubj|END_ENTITY	Silencing pancreatic_adenocarcinoma_upregulated_factor -LRB- PAUF -RRB- increases the sensitivity of pancreatic_cancer cells to gemcitabine .
18665163	0	gemcitabine	39,50	tAnGo	0,5	gemcitabine	tAnGo	MESH:C056507	375056	Chemical	Gene	trial|nmod|START_ENTITY END_ENTITY|dep|trial	tAnGo : a randomised phase III trial of gemcitabine in paclitaxel-containing , epirubicin/cyclophosphamide-based , adjuvant chemotherapy for early breast_cancer : a prospective pulmonary , cardiac and hepatic function evaluation .
25189999	0	gemcitabine	68,79	uhrf1	94,99	gemcitabine	uhrf1	MESH:C056507	29128	Chemical	Gene	resistance|amod|START_ENTITY resistance|nmod|END_ENTITY	Reversible epigenetic regulation of 14-3-3 expression in acquired gemcitabine resistance by uhrf1 and DNA methyltransferase 1 .
7755647	0	gemfibrozil	54,65	Insulin	0,7	gemfibrozil	Insulin	MESH:D015248	3630	Chemical	Gene	treatment|amod|START_ENTITY improved|nmod|treatment improved|nsubjpass|action action|compound|END_ENTITY	Insulin action and glucose metabolism are improved by gemfibrozil treatment in hypertriglyceridemic patients .
17470528	0	gemfibrozil	51,62	OATP	122,126	gemfibrozil	OATP	MESH:D015248	6579	Chemical	Gene	peptide|amod|START_ENTITY peptide|appos|END_ENTITY	Substrate-dependent drug-drug interactions between gemfibrozil , fluvastatin and other organic anion-transporting peptide -LRB- OATP -RRB- substrates on OATP1B1 , OATP2B1 , and OATP1B3 .
12204791	0	gemfibrozil	10,21	apolipoprotein_B	25,41	gemfibrozil	apolipoprotein B	MESH:D015248	338	Chemical	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	Effect of gemfibrozil on apolipoprotein_B secretion and diacylglycerol_acyltransferase activity in human hepatoblastoma -LRB- HepG2 -RRB- cells .
1678324	0	gemfibrozil	72,83	apolipoprotein_B	21,37	gemfibrozil	apolipoprotein B	MESH:D015248	338	Chemical	Gene	treatment|amod|START_ENTITY polymorphisms|nmod|treatment polymorphisms|nmod|genes genes|amod|END_ENTITY	DNA polymorphisms of apolipoprotein_B and AI/CIII genes and response to gemfibrozil treatment .
10657576	0	gemfibrozil	11,22	insulin	26,33	gemfibrozil	insulin	MESH:D015248	3630	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|sensitivity sensitivity|compound|END_ENTITY	Effects of gemfibrozil on insulin sensitivity and on haemostatic variables in hypertriglyceridemic patients .
12047397	0	gemfibrozil	11,22	insulin	26,33	gemfibrozil	insulin	MESH:D015248	3630	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	Effects of gemfibrozil on insulin resistance to fat metabolism in subjects with type 2 diabetes and hypertriglyceridaemia .
20852089	0	gemfibrozil	80,91	insulin	62,69	gemfibrozil	insulin	MESH:D015248	3630	Chemical	Gene	triglycerides|amod|START_ENTITY triglycerides|nmod|infusion infusion|compound|END_ENTITY	Rapid reduction of severely elevated serum triglycerides with insulin infusion , gemfibrozil and niacin .
7752906	0	gemfibrozil	27,38	insulin	110,117	gemfibrozil	insulin	MESH:D015248	3630	Chemical	Gene	therapy|amod|START_ENTITY triglyceride|nmod|therapy affect|nsubj|triglyceride affect|dobj|effect effect|nmod|END_ENTITY	Decreasing triglyceride by gemfibrozil therapy does not affect the glucoregulatory or antilipolytic effect of insulin in nondiabetic subjects with mild hypertriglyceridemia .
8458531	0	gemfibrozil	29,40	insulin	105,112	gemfibrozil	insulin	MESH:D015248	3630	Chemical	Gene	Lowering|nmod|START_ENTITY Lowering|dep|affects affects|dobj|effect effect|nmod|END_ENTITY	Lowering of triglycerides by gemfibrozil affects neither the glucoregulatory nor antilipolytic effect of insulin in type 2 -LRB- non-insulin-dependent -RRB- diabetic patients .
9024157	0	gemfibrozil	15,26	insulin	94,101	gemfibrozil	insulin	MESH:D015248	3630	Chemical	Gene	Attenuation|nmod|START_ENTITY induced|nsubj|Attenuation induced|nmod|END_ENTITY	Attenuation by gemfibrozil of expression of plasminogen_activator_inhibitor_type_1 induced by insulin and its precursors .
3555908	0	gemfibrozil	58,69	lipoprotein_lipase	17,35	gemfibrozil	lipoprotein lipase	MESH:D015248	4023	Chemical	Gene	results|amod|START_ENTITY Normalization|nmod|results Normalization|nmod|END_ENTITY	Normalization of lipoprotein_lipase and hepatic_lipase by gemfibrozil results in correction of lipoprotein_abnormalities in chronic_renal_failure .
8231846	0	gemfibrozil	10,21	lipoprotein_lipase	51,69	gemfibrozil	lipoprotein lipase	MESH:D015248	4023	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of gemfibrozil on adipose tissue and muscle lipoprotein_lipase .
12834305	0	gemfibrozil	130,141	peroxisome_proliferator-activated_receptor_alpha	156,204	gemfibrozil	peroxisome proliferator-activated receptor alpha	MESH:D015248	25747(Tax:10116)	Chemical	Gene	START_ENTITY|appos|ligand ligand|nmod|END_ENTITY	Preparation of antiserum against rat delta6-desaturase and its use to evaluate the desaturase protein levels in rats treated with gemfibrozil , a ligand for peroxisome_proliferator-activated_receptor_alpha .
9024157	0	gemfibrozil	15,26	plasminogen_activator_inhibitor_type_1	44,82	gemfibrozil	plasminogen activator inhibitor type 1	MESH:D015248	5054	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Attenuation by gemfibrozil of expression of plasminogen_activator_inhibitor_type_1 induced by insulin and its precursors .
9364979	0	gemfibrozil	11,22	tissue-type_plasminogen_activator	60,93	gemfibrozil	tissue-type plasminogen activator	MESH:D015248	5327	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|nmod|END_ENTITY	Effects of gemfibrozil and ciprofibrate on plasma levels of tissue-type_plasminogen_activator , plasminogen_activator_inhibitor-1 and fibrinogen in hyperlipidaemic patients .
21864659	0	gemifloxacin	66,78	P-gp	23,27	gemifloxacin	P-gp	MESH:C103274	283871	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Differential effect of P-gp and MRP2 on cellular translocation of gemifloxacin .
26187356	0	gemigliptin	37,48	Dipeptidyl_peptidase-4	0,22	gemigliptin	Dipeptidyl peptidase-4	MESH:C534891	1803	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Dipeptidyl_peptidase-4 inhibition by gemigliptin prevents abnormal_vascular_remodeling via NF-E2-related_factor_2 activation .
26187356	0	gemigliptin	37,48	Dipeptidyl_peptidase-4	0,22	gemigliptin	Dipeptidyl peptidase-4	MESH:C534891	1803	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Dipeptidyl_peptidase-4 inhibition by gemigliptin prevents abnormal_vascular_remodeling via NF-E2-related_factor_2 activation .
22534255	0	gemigliptin	66,77	dipeptidyl_peptidase-IV	81,104	gemigliptin	dipeptidyl peptidase-IV	MESH:C534891	1803	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effects of ketoconazole and rifampicin on the pharmacokinetics of gemigliptin , a dipeptidyl_peptidase-IV inhibitor : a crossover drug-drug interaction study in healthy male Korean volunteers .
24962635	0	gemigliptin	56,67	dipeptidylpeptidase-4	69,90	gemigliptin	dipeptidylpeptidase-4	MESH:C534891	1803	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Evaluation of pharmacokinetic drug interactions between gemigliptin -LRB- dipeptidylpeptidase-4 inhibitor -RRB- and glimepiride -LRB- sulfonylurea -RRB- in healthy volunteers .
20967268	6	genipin	992,999	MX2	1007,1010	genipin	MX2	MESH:C007834	4600	Chemical	Gene	START_ENTITY|nmod|cells cells|nummod|END_ENTITY	State 4 and resting cellular respiratory rates were higher in the MX2 cells in comparison to the HL-60 cells , and the increased respiration was readily suppressed by genipin in the MX2 cells .
24867506	0	geniposide	35,45	insulin	14,21	geniposide	insulin	MESH:C007835	3630	Chemical	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Regulation of insulin secretion by geniposide : possible involvement of phosphatidylinositol_3-phosphate kinase .
10370056	0	genistein	83,92	CFTR	63,67	genistein	CFTR	MESH:D019833	100135647(Tax:10141)	Chemical	Gene	current|nmod|START_ENTITY Lack|dep|current Lack|nmod|involvement involvement|nmod|proteins proteins|nmod|activation activation|nmod|Cl Cl|compound|END_ENTITY	Lack of involvement of G proteins in the activation of cardiac CFTR Cl - current by genistein .
10898722	0	genistein	66,75	CFTR	50,54	genistein	CFTR	MESH:D019833	1080	Chemical	Gene	phosphatases|nmod|START_ENTITY phosphatases|nmod|activation activation|nmod|END_ENTITY	Role of protein phosphatases in the activation of CFTR -LRB- ABCC7 -RRB- by genistein and bromotetramisole .
12914781	0	genistein	22,31	CFTR	14,18	genistein	CFTR	MESH:D019833	1080	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of CFTR by genistein in human airway epithelial cell lines .
15163550	0	genistein	131,140	CFTR	105,109	genistein	CFTR	MESH:D019833	1080	Chemical	Gene	abolishes|nmod|START_ENTITY abolishes|dobj|activation activation|nmod|channels channels|amod|END_ENTITY	The cystic_fibrosis mutation G1349D within the signature motif LSHGH of NBD2 abolishes the activation of CFTR chloride channels by genistein .
16859673	0	genistein	151,160	CFTR	53,57	genistein	CFTR	MESH:D019833	24255(Tax:10116)	Chemical	Gene	action|nmod|START_ENTITY mediate|dobj|action chloride|ccomp|mediate chloride|nsubj|Cystic_fibrosis_transmembrane_conductance_regulator Cystic_fibrosis_transmembrane_conductance_regulator|appos|END_ENTITY	Cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- chloride channel and Na-K-Cl cotransporter NKCC1 isoform mediate the vasorelaxant action of genistein in isolated rat aorta .
26529183	0	genistein	25,34	CFTR	109,113	genistein	CFTR	MESH:D019833	24255(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|level level|nmod|cystic_fibrosis_transmembrane_regulator cystic_fibrosis_transmembrane_regulator|appos|END_ENTITY	Combinatorial effects of genistein and sex-steroids on the level of cystic_fibrosis_transmembrane_regulator -LRB- CFTR -RRB- , adenylate cyclase -LRB- AC -RRB- and cAMP in the cervix of ovariectomised rats .
7537452	0	genistein	81,90	CFTR	31,35	genistein	CFTR	MESH:D019833	12638(Tax:10090)	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|channels channels|compound|END_ENTITY	cAMP-independent activation of CFTR Cl channels by the tyrosine kinase inhibitor genistein .
8770006	0	genistein	36,45	CFTR	0,4	genistein	CFTR	MESH:D019833	12638(Tax:10090)	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	CFTR chloride channel activation by genistein : the role of serine/threonine protein phosphatases .
8772453	0	genistein	40,49	CFTR	32,36	genistein	CFTR	MESH:D019833	1080	Chemical	Gene	stimulation|nmod|START_ENTITY stimulation|nmod|END_ENTITY	Alternate stimulation of apical CFTR by genistein in epithelia .
9211816	0	genistein	17,26	CFTR	30,34	genistein	CFTR	MESH:D019833	1080	Chemical	Gene	action|nmod|START_ENTITY action|nmod|END_ENTITY	Direct action of genistein on CFTR .
9852348	0	genistein	52,61	CFTR	69,73	genistein	CFTR	MESH:D019833	100135647(Tax:10141)	Chemical	Gene	START_ENTITY|nmod|Cl Cl|compound|END_ENTITY	Tyrosine kinase-independent extracellular action of genistein on the CFTR Cl - channel in guinea_pig ventricular myocytes and CFTR-transfected mouse fibroblasts .
12485911	0	genistein	39,48	CYP24	30,35	genistein	CYP24	MESH:D019833	1591	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Transcriptional inhibition of CYP24 by genistein .
11286989	0	genistein	11,20	Cdc2	129,133	genistein	Cdc2	MESH:D019833	983	Chemical	Gene	Effects|nmod|START_ENTITY Effects|dep|involvement involvement|nmod|END_ENTITY	Effects of genistein on cell proliferation and cell cycle arrest in nonneoplastic human mammary epithelial cells : involvement of Cdc2 , p21 -LRB- waf/cip1 -RRB- , p27 -LRB- kip1 -RRB- , and Cdc25C expression .
15968319	0	genistein	15,24	ERalpha	42,49	genistein	ERalpha	MESH:D019833	2099	Chemical	Gene	START_ENTITY|nmod|levels levels|nmod|END_ENTITY	-LSB- Regulation of genistein on the levels of ERalpha , ERbeta mRNA in uterine endometrial_cancer cells -RSB- .
22098108	0	genistein	33,42	IGF-1	14,19	genistein	IGF-1	MESH:D019833	3479	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Inhibition of IGF-1 signaling by genistein : modulation of E-cadherin expression and downregulation of b-catenin signaling in hormone refractory PC-3 prostate_cancer cells .
25382637	0	genistein	78,87	IL-6	50,54	genistein	IL-6	MESH:D019833	16193(Tax:10090)	Chemical	Gene	inhibited|nmod|START_ENTITY END_ENTITY|acl:relcl|inhibited	C/EBPb promotes angiogenesis through secretion of IL-6 , which is inhibited by genistein , in EGFRvIII-positive glioblastoma .
18621112	0	genistein	51,60	LDL_receptor	19,31	genistein	LDL receptor	MESH:D019833	3949	Chemical	Gene	induction|nmod|START_ENTITY induction|nmod|expression expression|compound|END_ENTITY	Early induction of LDL_receptor gene expression by genistein in DLD-1 colon_cancer cell line .
22125674	0	genistein	22,31	MCP-1	66,71	genistein	MCP-1	MESH:D019833	6347	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Comparative effect of genistein and daidzein on the expression of MCP-1 , eNOS , and cell adhesion molecules in TNF-a-stimulated HUVECs .
23438830	0	genistein	39,48	MicroRNA-27a	10,22	genistein	MicroRNA-27a	MESH:D019833	407018	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Oncogenic MicroRNA-27a is a target for genistein in ovarian_cancer cells .
22272764	8	genistein	1458,1467	Nrf2	1269,1273	genistein	PI3K	MESH:D019833	18708(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY attenuate|dobj|effects Nrf2|dep|attenuate NF-E2-related_factor_2|appos|Nrf2 NF-E2-related_factor_2|appos|END_ENTITY	Genistein could reverse the down-regulation of total protein and mRNA expression of NF-E2-related_factor_2 -LRB- Nrf2 -RRB- , nuclear Nrf2 , y-glutamylcysteine synthetase -LRB- y-GCS -RRB- , phosphatidylinositol_3-kinase -LRB- PI3K -RRB- induced by Ab25-35 ; while PI3K inhibitor LY294002 could attenuate the activation effects of genistein on Nrf2 , especially for the promotion of nuclear translocation .
23255485	0	genistein	18,27	Nrf2	36,40	genistein	Nrf2	MESH:D019833	4780	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Dietary flavonoid genistein induces Nrf2 and phase II detoxification gene expression via ERKs and PKC pathways and protects against oxidative stress in Caco-2 cells .
11459812	0	genistein	119,128	OPG	84,87	genistein	OPG	MESH:D019833	21943(Tax:10090)	Chemical	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	Reciprocal control of expression of mRNAs for osteoclast_differentiation_factor and OPG in osteogenic stromal cells by genistein : evidence for the involvement of topoisomerase II in osteoclastogenesis .
12767922	0	genistein	38,47	P21	0,3	genistein	P21	MESH:D019833	1026	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|response response|nummod|END_ENTITY	P21 response to DNA damage induced by genistein and etoposide in human lung_cancer cells .
12421816	0	genistein	110,119	Peroxisome_proliferator-activated_receptor_gamma	0,48	genistein	Peroxisome proliferator-activated receptor gamma	MESH:D019833	5468	Chemical	Gene	target|nmod|START_ENTITY END_ENTITY|nmod|target	Peroxisome_proliferator-activated_receptor_gamma -LRB- PPARgamma -RRB- as a molecular target for the soy phytoestrogen genistein .
12242023	6	genistein	761,770	SB_203580	950,959	genistein	NF-kappaB	MESH:D019833	18033(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|appos|END_ENTITY	The tyrosine kinase inhibitor , genistein , the phosphatidylinositol-3-kinase -LRB- PI_3-K -RRB- inhibitor , LY_294002 , the protein kinase C -LRB- PKC -RRB- inhibitor , Ro_31-8220 , and the p38 mitogen-activated protein kinase -LRB- MAPK -RRB- inhibitor , SB_203580 , all inhibited AGEs-stimulated iNOS expression , NO release , NF-kappaB translocation and NF-kappaB DNA binding activity .
14627498	0	genistein	21,30	STAT3	48,53	genistein	STAT3	MESH:D019833	25125(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Inhibitory effect of genistein on activation of STAT3 induced by brain_ischemia / reperfusion in rat hippocampus .
17615260	0	genistein	45,54	STAT3	130,135	genistein	STAT3	MESH:D019833	6774	Chemical	Gene	concentrations|nmod|START_ENTITY enhance|nsubj|concentrations enhance|nmod|cells cells|nmod|activation activation|nmod|END_ENTITY	Physiologically achievable concentrations of genistein enhance telomerase activity in prostate_cancer cells via the activation of STAT3 .
12811578	0	genistein	70,79	VEGF	84,88	genistein	VEGF	MESH:D019833	7422	Chemical	Gene	tea|appos|START_ENTITY polyphenols|nmod|tea polyphenols|nmod|END_ENTITY	Comparative effects of polyphenols from green tea -LRB- EGCG -RRB- and soybean -LRB- genistein -RRB- on VEGF and IL-8 release from normal human keratinocytes stimulated with the proinflammatory cytokine TNFalpha .
20816816	0	genistein	52,61	a7_nicotinic_acetylcholine_receptor	69,104	genistein	a7 nicotinic acetylcholine receptor	MESH:D019833	1139	Chemical	Gene	Importance|nmod|START_ENTITY Importance|nmod|END_ENTITY	Importance of M2-M3 loop in governing properties of genistein at the a7_nicotinic_acetylcholine_receptor inferred from a7/5-HT 3A chimera .
21712365	0	genistein	93,102	adiponectin	17,28	genistein	adiponectin	MESH:D019833	9370	Chemical	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Paracrine-acting adiponectin promotes mammary epithelial differentiation and synergizes with genistein to enhance transcriptional response to estrogen_receptor b signaling .
11117383	0	genistein	10,19	angiotensin_II	51,65	genistein	angiotensin II	MESH:D019833	24179(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of genistein on cardiovascular responses to angiotensin_II in conscious unrestrained rats .
16722796	0	genistein	21,30	basic_fibroblast_growth_factor	50,80	genistein	basic fibroblast growth factor	MESH:D019833	2247	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|compound|END_ENTITY	Inhibitive effect of genistein on hypoxia-induced basic_fibroblast_growth_factor expression in human retinal_pigment_epithelium cells .
23614275	0	genistein	13,22	c-Jun	26,31	genistein	c-Jun	MESH:D019833	3725	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of genistein on c-Jun , c-Fos and Fos-B of AP-1 subunits expression in skin keratinocytes , fibroblasts and keloid fibroblasts cultured in vitro .
10427135	0	genistein	73,82	c-erbB-2	41,49	genistein	c-erbB-2	MESH:D019833	2064	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|cells cells|amod|END_ENTITY	Induction of apoptosis and inhibition of c-erbB-2 in MDA-MB-435 cells by genistein .
21594328	0	genistein	21,30	c-fos	59,64	genistein	c-fos	MESH:D019833	14281(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY promoter-induced|nsubj|effect promoter-induced|dobj|expression expression|amod|END_ENTITY	Inhibitory effect of genistein on a tumor promoter-induced c-fos and c-jun expression in mouse skin .
8298195	0	genistein	194,203	c-fos	176,181	genistein	c-fos	MESH:D019833	2353	Chemical	Gene	promoter|nmod|START_ENTITY promoter|amod|END_ENTITY	Differential regulation of early response genes and cell proliferation through the human granulocyte_macrophage_colony-stimulating_factor receptor : selective activation of the c-fos promoter by genistein .
9600350	0	genistein	108,117	c-fos	42,47	genistein	c-fos	MESH:D019833	14281(Tax:10090)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|acl|induced induced|dobj|expression expression|amod|END_ENTITY	Inhibition of ultraviolet B -LRB- UVB -RRB- - induced c-fos and c-jun expression in vivo by a tyrosine kinase inhibitor genistein .
15194215	0	genistein	73,82	cyclooxygenase-2	14,30	genistein	cyclooxygenase-2	MESH:D019833	5743	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activity activity|amod|END_ENTITY	Inhibition of cyclooxygenase-2 activity in head_and_neck_cancer cells by genistein .
22289529	0	genistein	94,103	cyclooxygenase-2	66,82	genistein	cyclooxygenase-2	MESH:D019833	5743	Chemical	Gene	COX-2|nmod|START_ENTITY COX-2|amod|END_ENTITY	Involvement of nuclear factor kB -LRB- NF-kB -RRB- in the downregulation of cyclooxygenase-2 -LRB- COX-2 -RRB- by genistein in gastric_cancer cells .
15968435	0	genistein	14,23	eNOS	50,54	genistein	eNOS	MESH:D019833	24600(Tax:10116)	Chemical	Gene	increases|compound|START_ENTITY END_ENTITY|nsubj|increases	Phytoestrogen genistein supplementation increases eNOS and decreases caveolin-1 expression in ovariectomized rat hearts .
22669896	0	genistein	14,23	endothelial_nitric_oxide_synthase	37,70	genistein	endothelial nitric oxide synthase	MESH:D019833	4846	Chemical	Gene	up-regulates|compound|START_ENTITY END_ENTITY|nsubj|up-regulates	Phytoestrogen genistein up-regulates endothelial_nitric_oxide_synthase expression via activation of cAMP response element-binding protein in human aortic endothelial cells .
19665144	0	genistein	54,63	epidermal_growth_factor_receptor	11,43	genistein	epidermal growth factor receptor	MESH:D019833	24329(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|inhibitor inhibitor|compound|END_ENTITY	Effects of epidermal_growth_factor_receptor inhibitor genistein on proliferative_cholangitis in rats .
9833772	0	genistein	52,61	epidermal_growth_factor_receptor	78,110	genistein	epidermal growth factor receptor	MESH:D019833	1956	Chemical	Gene	motility|nmod|START_ENTITY Inhibition|nmod|motility dependent|nsubj|Inhibition dependent|nmod|END_ENTITY	Inhibition of human bladder_cancer cell motility by genistein is dependent on epidermal_growth_factor_receptor but not p21ras gene expression .
18320719	0	genistein	32,41	growth_hormone	45,59	genistein	growth hormone	MESH:D019833	2688	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|amod|END_ENTITY	Central estrogen-like effect of genistein on growth_hormone secretion in the ewe .
18315897	0	genistein	22,31	hypoxia-inducible_factor-1alpha	35,66	genistein	hypoxia-inducible factor-1alpha	MESH:D019833	3091	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Inhibitory effect of genistein on hypoxia-inducible_factor-1alpha expression induced by cobalt_chloride in leukemia cell line K562 -RSB- .
19230619	0	genistein	10,19	insulin	23,30	genistein	insulin	MESH:D019833	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|resistance resistance|compound|END_ENTITY	Effect of genistein on insulin resistance , renal lipid metabolism , and antioxidative activities in ovariectomized rats .
16845446	0	genistein	21,30	interleukin-8	34,47	genistein	interleukin-8	MESH:D019833	3576	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|amod|END_ENTITY	Inhibitive effect of genistein on interleukin-8 expression in cultured human retinal pigment epithelial cells .
22931613	0	genistein	37,46	livin	11,16	genistein	livin	MESH:D019833	79444	Chemical	Gene	suppression|nmod|START_ENTITY suppression|compound|END_ENTITY	-LSB- Effect of livin gene suppression by genistein on apoptosis , cell cycle and proliferation of malignant_melanoma LiBr cells -RSB- .
22884883	0	genistein	21,30	matrix_metalloproteinase-1	158,184	genistein	matrix metalloproteinase-1	MESH:D019833	4312	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|amod|END_ENTITY	Inhibitory effect of genistein on the invasive potential of human cervical_cancer cells via modulation of matrix_metalloproteinase-9 and tissue inhibitors of matrix_metalloproteinase-1 expression .
22740468	0	genistein	8,17	myosin_light_chain	57,75	genistein	myosin light chain	MESH:D019833	170790(Tax:10090)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Dietary genistein enhances phosphorylation of regulatory myosin_light_chain in the myocardium of ovariectomized mice .
20087855	0	genistein	45,54	noradrenaline_transporter	58,83	genistein	noradrenaline transporter	MESH:D019833	6530	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Stimulatory effects of the soy phytoestrogen genistein on noradrenaline_transporter and serotonin_transporter activity .
20225658	0	genistein	15,24	nuclear_factor-kappaB	59,80	genistein	nuclear factor-kappaB	MESH:D019833	4790	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activation activation|nmod|END_ENTITY	The effects of genistein and puerarin on the activation of nuclear_factor-kappaB and the production of tumor_necrosis_factor-alpha in asthma patients .
8700131	0	genistein	95,104	ornithine_decarboxylase	59,82	genistein	ornithine decarboxylase	MESH:D019833	4953	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activity activity|compound|END_ENTITY	Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine_decarboxylase activity by genistein , a tyrosine kinase inhibitor .
11835398	0	genistein	14,23	osteoprotegerin	53,68	genistein	osteoprotegerin	MESH:D019833	4982	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|nmod|END_ENTITY	Phytoestrogen genistein stimulates the production of osteoprotegerin by human trabecular osteoblasts .
11410520	0	genistein	76,85	p21	108,111	genistein	p21	MESH:D019833	1026	Chemical	Gene	cells|nmod|START_ENTITY sensitivity|nmod|cells mediated|nsubjpass|sensitivity mediated|nmod|END_ENTITY	Differential sensitivity of normal and malignant breast epithelial cells to genistein is partly mediated by p21 -LRB- WAF1 -RRB- .
22065906	0	genistein	21,30	p21	84,87	genistein	p21	MESH:D019833	644914	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Apoptotic effects of genistein , biochanin-A and apigenin on LNCaP and PC-3 cells by p21 through transcriptional inhibition of polo-like kinase-1 .
17015169	0	genistein	18,27	p38	142,145	genistein	p38	MESH:D019833	1432	Chemical	Gene	metabolite|nsubj|START_ENTITY metabolite|dobj|,4 ,4|dep|arrest arrest|nmod|cells cells|nmod|modulation modulation|nmod|pathway pathway|amod|END_ENTITY	The intracellular genistein metabolite 5,7,3 ' ,4 ' - tetrahydroxyisoflavone mediates G2-M cell cycle arrest in cancer cells via modulation of the p38 signaling pathway .
10811979	0	genistein	54,63	prostate_specific_antigen	14,39	genistein	prostate specific antigen	MESH:D019833	354	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|expression expression|compound|END_ENTITY	Inhibition of prostate_specific_antigen expression by genistein in prostate_cancer cells .
9703891	0	genistein	23,32	transforming_growth_factor_beta_1	36,69	genistein	transforming growth factor beta 1	MESH:D019833	7040	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|amod|END_ENTITY	Differential effect of genistein on transforming_growth_factor_beta_1 expression in normal and malignant mammary epithelial cells .
8963342	0	genistein	31,40	vasopressin	80,91	genistein	vasopressin	MESH:D019833	551	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|effect effect|nmod|END_ENTITY	-LSB- The tyrosine kinase inhibitor genistein potentiates the antidiuretic effect of vasopressin and its analogs -RSB- .
17675381	0	genitalium	38,48	MG312	49,54	genitalium	MG312	null	875568(Tax:243273)	Chemical	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Functional analysis of the Mycoplasma genitalium MG312 protein reveals a specific requirement of the MG312_N-terminal domain for gliding motility .
20423008	0	gensenoside_Rg1	36,51	P-Tau	70,75	gensenoside Rg1	P-Tau	null	29477(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expressions expressions|nmod|END_ENTITY	-LSB- Experimental research on effect of gensenoside_Rg1 on expressions of P-Tau and caspase-3 in brain slices from AD model rats -RSB- .
21785162	0	gentamicin	22,32	Calreticulin	0,12	gentamicin	Calreticulin	MESH:D005839	12317(Tax:10090)	Chemical	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	Calreticulin binds to gentamicin and reduces drug-induced ototoxicity .
25087119	0	gentamicin	58,68	KIM-1	0,5	gentamicin	KIM-1	MESH:D005839	286934(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|END_ENTITY	KIM-1 and NGAL as biomarkers of nephrotoxicity induced by gentamicin in rats .
3447879	0	gentamicin	23,33	N-acetyl-beta-D-glucosaminidase	75,106	gentamicin	N-acetyl-beta-D-glucosaminidase	MESH:D005839	154968(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|excretion excretion|nmod|END_ENTITY	Comparative effects of gentamicin , amikacin and dactimicin on excretion of N-acetyl-beta-D-glucosaminidase -LRB- NAG -RRB- and kidney histological pattern in rats .
4073872	0	gentamicin	23,33	N-acetyl-beta-D-glucosaminidase	65,96	gentamicin	N-acetyl-beta-D-glucosaminidase	MESH:D005839	10724	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Comparative effects of gentamicin and tobramycin on excretion of N-acetyl-beta-D-glucosaminidase .
6172216	0	gentamicin	163,173	N-acetyl-beta-D-glucosaminidase	28,59	gentamicin	N-acetyl-beta-D-glucosaminidase	MESH:D005839	10724	Chemical	Gene	nephrotoxicity|nmod|START_ENTITY evaluating|dobj|nephrotoxicity Predictive|advcl|evaluating Predictive|dobj|value value|nmod|END_ENTITY	Predictive value of urinary N-acetyl-beta-D-glucosaminidase -LRB- NAG -RRB- , alanine-aminopeptidase -LRB- AAP -RRB- and beta-2-microglobulin -LRB- beta_2M -RRB- in evaluating nephrotoxicity of gentamicin .
9713010	0	gentamicin	95,105	N-acetyl-beta-D-glucosaminidase	8,39	gentamicin	N-acetyl-beta-D-glucosaminidase	MESH:D005839	10724	Chemical	Gene	inhalation|compound|START_ENTITY cystic_fibrosis|nmod|inhalation activity|nmod|cystic_fibrosis activity|amod|END_ENTITY	Urinary N-acetyl-beta-D-glucosaminidase activity in patients with cystic_fibrosis on long-term gentamicin inhalation .
1686729	0	gentamicin	61,71	aminopeptidase	29,43	gentamicin	aminopeptidase	MESH:D005839	10404	Chemical	Gene	therapy|compound|START_ENTITY END_ENTITY|nmod|therapy	Infradian rhythms of alanine aminopeptidase excretion during gentamicin therapy .
1982298	0	gentamicin	80,90	erythropoietin	28,42	gentamicin	erythropoietin	MESH:D005839	2056	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Effect Effect|nmod|END_ENTITY	Effect of recombinant human erythropoietin on new anaemic model rats induced by gentamicin .
6810292	0	gentamicin	29,39	lactase	54,61	gentamicin	lactase	MESH:D005839	116569(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of asphyxia and oral gentamicin on intestinal lactase in the suckling rat .
1745025	0	gentamicin	38,48	platelet_activating_factor	8,34	gentamicin	platelet activating factor	MESH:D005839	300795(Tax:10116)	Chemical	Gene	nephrotoxicity|compound|START_ENTITY Role|nmod|nephrotoxicity Role|nmod|END_ENTITY	Role of platelet_activating_factor in gentamicin and cisplatin nephrotoxicity .
8184148	0	gentamicin	11,21	renin	36,41	gentamicin	renin	MESH:D005839	24715(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|release release|compound|END_ENTITY	Effects of gentamicin on glomerular renin release .
23582420	0	gentamicin	21,31	tmie	0,4	gentamicin	tmie	MESH:D005839	20776(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY required|nmod|uptake required|nsubjpass|END_ENTITY	tmie Is required for gentamicin uptake by the hair cells of mice .
2565390	0	gepirone	10,18	prolactin	82,91	gepirone	prolactin	MESH:C039979	24683(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|nmod|END_ENTITY	Effect of gepirone and ipsapirone on the stimulated and unstimulated secretion of prolactin in the rat .
24066128	0	geraniin	37,45	Hsp90	57,62	geraniin	Hsp90	MESH:C024603	3320	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|compound|END_ENTITY	Identification of the plant compound geraniin as a novel Hsp90 inhibitor .
10952986	0	geranyl	19,26	Nm23	58,62	geranyl	Nm23	null	4830	Chemical	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of geranyl and farnesyl_pyrophosphates by Nm23 proteins/nucleoside _ diphosphate kinases .
24406160	0	geranylgeranoic_acid	71,91	lysine-specific_demethylase_1	14,43	geranylgeranoic acid	lysine-specific demethylase 1	MESH:C040155	23028	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of lysine-specific_demethylase_1 by the acyclic_diterpenoid geranylgeranoic_acid and its derivatives .
22206343	0	geranylgeranyl	67,81	RhoGDI	98,104	geranylgeranyl	RhoGDI	null	396	Chemical	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Structural coupling between the Rho-insert domain of Cdc42 and the geranylgeranyl binding site of RhoGDI .
24631258	0	geranylgeranylacetone	21,42	HSPB1	69,74	geranylgeranylacetone	HSPB1	MESH:C031049	24471(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Protective effect of geranylgeranylacetone via enhanced induction of HSPB1 and HSPB8 in mitochondria of the failing heart following myocardial_infarction in rats .
19399179	0	geranylgeranylacetone	21,42	HSPB8	62,67	geranylgeranylacetone	HSPB8	MESH:C031049	80888(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|enhancement enhancement|nmod|END_ENTITY	Protective effect of geranylgeranylacetone via enhancement of HSPB8 induction in desmin-related_cardiomyopathy .
16240224	0	geranylgeranylacetone	65,86	MUC5AC	46,52	geranylgeranylacetone	MUC5AC	MESH:C031049	682837(Tax:10116)	Chemical	Gene	protection|nmod|START_ENTITY protection|nmod|END_ENTITY	Gastric mucosal protection via enhancement of MUC5AC and MUC6 by geranylgeranylacetone .
17971294	0	geranylgeranylacetone	75,96	NF-kappaB	22,31	geranylgeranylacetone	NF-kappaB	MESH:C031049	4790	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Blunted activation of NF-kappaB and NF-kappaB-dependent gene expression by geranylgeranylacetone : involvement of unfolded protein response .
12714633	0	geranylgeranylacetone	38,59	heat_shock_protein	63,81	geranylgeranylacetone	heat shock protein	MESH:C031049	290549(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inducer inducer|compound|END_ENTITY	Retinal ganglion cell protection with geranylgeranylacetone , a heat_shock_protein inducer , in a rat glaucoma model .
18028136	0	geranylgeranylacetone	123,144	heat_shock_protein	98,116	geranylgeranylacetone	heat shock protein	MESH:C031049	290549(Tax:10116)	Chemical	Gene	Reduction|nmod|START_ENTITY Reduction|nmod|END_ENTITY	Reduction of ethanol-induced injury_in_portal_hypertensive_gastric_mucosa of rats by induction of heat_shock_protein 72 by geranylgeranylacetone .
20707379	0	germanium	26,35	spin	8,12	germanium	spin	MESH:D005857	10927	Chemical	Gene	injection|nmod|START_ENTITY injection|compound|END_ENTITY	Lateral spin injection in germanium nanowires .
8462317	0	gestodene	13,22	CBG	146,149	gestodene	CBG	MESH:C033273	866	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of gestodene and desogestrel as components of low-dose oral contraceptives on the pharmacokinetics of ethinyl_estradiol -LRB- EE2 -RRB- , on serum CBG and on urinary cortisol and 6 beta-hydroxycortisol .
2144750	0	gestodene	19,28	estrogen_receptor	32,49	gestodene	estrogen receptor	MESH:C033273	2099	Chemical	Gene	Lack|nmod|START_ENTITY Lack|nmod|END_ENTITY	Lack of binding of gestodene to estrogen_receptor in human breast_cancer tissue .
20193490	0	gingerol	10,18	substance_P	22,33	gingerol	substance P	MESH:C007845	6863	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effect of gingerol on substance_P and NK1_receptor expression in a vomiting model of mink .
26983212	0	gingerols	24,33	TNF-a	42,47	gingerols	TNF-a	null	7124	Chemical	Gene	START_ENTITY|nmod|release release|amod|END_ENTITY	-LSB- Antagonistic effect of gingerols against TNF-a release , ROS overproduction and RIP3 expression increase induced by lectin from Pinellia ternata -RSB- .
19102726	0	gingipain	16,25	osteoprotegerin	125,140	gingipain	osteoprotegerin	MESH:C076657	18383(Tax:10090)	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Lysine-specific gingipain promotes lipopolysaccharide - and active-vitamin_D3-induced osteoclast differentiation by degrading osteoprotegerin .
24980806	0	ginkgolic_acids	45,60	P-gp	79,83	ginkgolic acids	P-gp	null	610926(Tax:9615)	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Cyclosporin_A affects the bioavailability of ginkgolic_acids via inhibition of P-gp and BCRP .
17441350	0	ginkgolide_B	15,27	GFAP	41,45	ginkgolide B	GFAP	MESH:C045856	2670	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nsubj|effect	-LSB- The effect of ginkgolide_B on astrocyte GFAP expression after the focal cerebral_ischemia -RSB- .
15491096	0	ginkgolide_B	12,24	TNFalpha	55,63	ginkgolide B	TNFalpha	MESH:C045856	21926(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	-LSB- Effects of ginkgolide_B on lipopolysaccharide-induced TNFalpha production in mouse peritoneal macrophages and NF-kappaB activation in rat pleural polymorphonuclear leukocytes -RSB- .
21141514	0	ginkgolide_B	11,23	interleukin-12	44,58	ginkgolide B	interleukin-12	MESH:C045856	64546(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|levels levels|nmod|END_ENTITY	-LSB- Effect of ginkgolide_B on plasma levels of interleukin-12 and PAF in severe_acute_pancreatitis in rats -RSB- .
18953964	0	ginkgolide_B	32,44	interleukin-8	48,61	ginkgolide B	interleukin-8	MESH:C045856	20309(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	-LSB- The mechanism of inhibition by ginkgolide_B on interleukin-8 production induced by 4-hydroxynonenal in bronchial epithelial cells -RSB- .
21158113	0	ginkgolides	11,22	HIF-1alpha	45,55	ginkgolides	HIF-1alpha	MESH:D046934	3091	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of ginkgolides on gene expression of HIF-1alpha in primary cultured neurons -RSB- .
21180125	0	ginkgolides	37,48	HIF-1alpha	15,25	ginkgolides	HIF-1alpha	MESH:D046934	3091	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	-LSB- Expression of HIF-1alpha induced by ginkgolides in primary cultured cortical neurons and the relationship with ERK signal pathway -RSB- .
16161431	0	ginkgolides	12,23	cytochrome_P-450	54,70	ginkgolides	cytochrome P-450	MESH:D046934	25251(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Effects of ginkgolides on gene expression of hepatic cytochrome_P-450 in rats -RSB- .
19958278	0	ginkgolides_A_and_B	16,35	prion_protein	61,74	ginkgolides A and B	prion protein	null	5621	Chemical	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of ginkgolides_A_and_B with a recombinant human prion_protein .
17581220	0	ginkgolides_a_and_B	63,82	cyp3a	13,18	ginkgolides a and B	cyp3a	null	1576	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of cyp3a in primary cultures of human hepatocytes by ginkgolides_a_and_B .
17204170	0	ginseng_saponin	10,25	CTX	72,75	ginseng saponin	CTX	null	1593	Chemical	Gene	Effect|nmod|START_ENTITY combined|nsubj|Effect combined|nmod|END_ENTITY	Effect of ginseng_saponin , arsenic_trioxide , beta-elemene combined with CTX on telomere-telomerase system in K562 cell line .
11501043	0	ginsenoside	10,21	IL-1_beta	25,34	ginsenoside	IL-1 beta	CHEBI:74978	24494(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of ginsenoside on IL-1_beta and IL-6 mRNA expression in hippocampal neurons in chronic inflammation model of aged rats .
17490654	0	ginsenoside-Re	23,37	glucocorticoid_receptor	63,86	ginsenoside-Re	glucocorticoid receptor	MESH:C049864	2908	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Non-genomic effects of ginsenoside-Re in endothelial cells via glucocorticoid_receptor .
22553558	0	ginsenoside-Rg3	10,25	VEGF	47,51	ginsenoside-Rg3	VEGF	MESH:C097367	83785(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effect of ginsenoside-Rg3 on the expression of VEGF and TNF-a in retina with diabetic rats .
23713254	0	ginsenoside_Rb1	12,27	tyrosine_kinase_B	54,71	ginsenoside Rb1	tyrosine kinase B	MESH:C442759	25054(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of ginsenoside_Rb1 on the mRNA expression of tyrosine_kinase_B in the hippocampus of acute immobilization stress rats -RSB- .
17524357	0	ginsenoside_Rd	33,47	cyclooxygenase-2	13,29	ginsenoside Rd	cyclooxygenase-2	MESH:C049863	19225(Tax:10090)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of cyclooxygenase-2 by ginsenoside_Rd via activation of CCAAT-enhancer binding proteins and cyclic_AMP response binding protein .
22940185	0	ginsenoside_Re	26,40	Th1	0,3	ginsenoside Re	Th1	MESH:C049864	57314(Tax:10090)	Chemical	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Th1 immunity induction by ginsenoside_Re involves in protection of mice against disseminated_candidiasis due to Candida_albicans .
14653954	0	ginsenoside_Rg1	38,53	CDK4	15,19	ginsenoside Rg1	CDK4	MESH:C035054	94201(Tax:10116)	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of CDK4 , pRB , and E2F1 in ginsenoside_Rg1 protecting rat cortical neurons from beta-amyloid-induced apoptosis .
9772672	0	ginsenoside_Rg1	11,26	c-fos	30,35	ginsenoside Rg1	c-fos	MESH:C035054	314322(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effects of ginsenoside_Rg1 on c-fos gene expression and cAMP levels in rat hippocampus .
19022240	0	ginsenoside_Rg1	47,62	cytochrome_P450_1A1	13,32	ginsenoside Rg1	cytochrome P450 1A1	MESH:C035054	1543	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|expression expression|amod|END_ENTITY	Induction of cytochrome_P450_1A1 expression by ginsenoside_Rg1 and Rb1 in HepG2 cells .
18782533	0	ginsenoside_Rg1	12,27	insulin-like_growth_factor-1	45,73	ginsenoside Rg1	insulin-like growth factor-1	MESH:C035054	24482(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Effects of ginsenoside_Rg1 on expression of insulin-like_growth_factor-1 in brain of rats with brain_contusion -RSB- .
15981886	0	ginsenoside_Rg1	11,26	neprilysin	30,40	ginsenoside Rg1	neprilysin	MESH:C035054	4311	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	-LSB- Effect of ginsenoside_Rg1 on neprilysin expression induced by LPS in SK-N-SH cell line -RSB- .
16487547	0	ginsenoside_Rg1	30,45	tumor_necrosis_factor-alpha	102,129	ginsenoside Rg1	tumor necrosis factor-alpha	MESH:C035054	7124	Chemical	Gene	effects|nmod|START_ENTITY stimulated|nsubj|effects stimulated|nmod|END_ENTITY	Proteomic analysis effects of ginsenoside_Rg1 on human umbilical vein endothelial cells stimulated by tumor_necrosis_factor-alpha .
24180280	0	ginsenoside_Rg3	34,49	DDX3	15,19	ginsenoside Rg3	DDX3	MESH:C097367	1654	Chemical	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Stimulation of DDX3 expression by ginsenoside_Rg3 through the Akt/p53 pathway activates the innate immune response via TBK1/IKK / IRF3 signalling .
12628505	0	ginsenoside_Rg3	26,41	cyclooxygenase-2	67,83	ginsenoside Rg3	cyclooxygenase-2	MESH:C097367	19225(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|amod|END_ENTITY	Inhibitory effects of the ginsenoside_Rg3 on phorbol_ester-induced cyclooxygenase-2 expression , NF-kappaB activation and tumor promotion .
25824408	0	ginsenoside_Rg3	15,30	epidermal_growth_factor_receptor	70,102	ginsenoside Rg3	epidermal growth factor receptor	MESH:C097367	1956	Chemical	Gene	roles|nmod|START_ENTITY roles|nmod|END_ENTITY	Novel roles of ginsenoside_Rg3 in apoptosis through downregulation of epidermal_growth_factor_receptor .
19627007	0	ginsenoside_Rgl	11,26	TNF-alpha	48,57	ginsenoside Rgl	TNF-alpha	null	24835(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of ginsenoside_Rgl on the expression of TNF-alpha and MCP-1 in rats with diabetic_nephropathy -RSB- .
9000124	0	ginsenoside_Rh2	54,69	Cdk2	37,41	ginsenoside Rh2	Cdk2	MESH:C055305	12566(Tax:10090)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	G1 phase-specific suppression of the Cdk2 activity by ginsenoside_Rh2 in cultured murine cells .
24557544	0	ginsenoside_Rh2	62,77	EGFR	0,4	ginsenoside Rh2	EGFR	MESH:C055305	1956	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	EGFR signaling-dependent inhibition of glioblastoma growth by ginsenoside_Rh2 .
25051397	0	ginsenoside_Rh2	10,25	histone_deacetylase	94,113	ginsenoside Rh2	histone deacetylase	MESH:C055305	9734	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|END_ENTITY	Effect of ginsenoside_Rh2 on the migratory ability of HepG2 liver_carcinoma cells : recruiting histone_deacetylase and inhibiting activator_protein_1 transcription factors .
18313848	0	ginsenoside_Rh2	84,99	pituitary_adenylate_cyclase-activating_polypeptide	8,58	ginsenoside Rh2	pituitary adenylate cyclase-activating polypeptide	MESH:C055305	24166(Tax:10116)	Chemical	Gene	action|nmod|START_ENTITY Role|nmod|action Role|nmod|END_ENTITY	Role of pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- in the action of ginsenoside_Rh2 against beta-amyloid-induced inhibition of rat brain astrocytes .
16922812	0	ginsenosides	22,34	CYP2C19	66,73	ginsenosides	CYP2C19	MESH:D036145	1557	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Effects of individual ginsenosides , ginkgolides and flavonoids on CYP2C19 and CYP2D6 activity in human liver microsomes .
15467194	0	ginsenosides	60,72	CYP3A	76,81	ginsenosides	CYP3A	MESH:D036145	170509(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	The inhibitory effect of intestinal bacterial metabolite of ginsenosides on CYP3A activity .
12485900	0	ginsenosides	20,32	NF-kappaB	107,116	ginsenosides	NF-kappaB	MESH:D036145	18033(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of selected ginsenosides on phorbol_ester-induced expression of cyclooxygenase-2 and activation of NF-kappaB and ERK1/2 in mouse skin .
9218681	0	ginsenosides	11,23	choline_acetyltransferase	54,79	ginsenosides	choline acetyltransferase	MESH:D036145	290567(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of ginsenosides on maze performance and brain choline_acetyltransferase activity in scopolamine-treated young rats and aged rats .
23592201	0	ginsenosides	76,88	cyclin-dependent_kinase_5	106,131	ginsenosides	cyclin-dependent kinase 5	MESH:D036145	1020	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Determination of kinetic parameters and structure-activity relationships of ginsenosides as inhibitors of cyclin-dependent_kinase_5 / p25 using ultra-pressure liquid chromatography with triple quadrupole tandem mass spectrometry .
12485900	0	ginsenosides	20,32	cyclooxygenase-2	72,88	ginsenosides	cyclooxygenase-2	MESH:D036145	19225(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of selected ginsenosides on phorbol_ester-induced expression of cyclooxygenase-2 and activation of NF-kappaB and ERK1/2 in mouse skin .
9877210	0	ginsenosides	78,90	glucocorticoid_receptor	15,38	ginsenosides	glucocorticoid receptor	MESH:D036145	2908	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of glucocorticoid_receptor in the induction of differentiation by ginsenosides in F9 teratocarcinoma cells .
10432216	0	ginsenosides	11,23	tyrosine_hydroxylase	42,62	ginsenosides	tyrosine hydroxylase	MESH:D036145	280707(Tax:9913)	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of ginsenosides on bovine adrenal tyrosine_hydroxylase .
20218294	0	ginsenosides_Rg3	16,32	VEGF_and_KDR	55,67	ginsenosides Rg3	VEGF and KDR	null	7422;3791	Chemical	Gene	START_ENTITY|nmod|expressions expressions|nmod|END_ENTITY	-LSB- The effects of ginsenosides_Rg3 on the expressions of VEGF_and_KDR in human lung squamous cancer cells -RSB- .
18160047	0	glargine	52,60	insulin	27,34	glargine	insulin	MESH:C106526	3630	Chemical	Gene	administration|amod|START_ENTITY levels|nmod|administration levels|compound|END_ENTITY	Differences in circulating insulin levels following glargine administration .
21715233	0	glassy_carbon	71,84	tyrosinase	57,67	glassy carbon	tyrosinase	null	7299	Chemical	Gene	enhancement|nmod|START_ENTITY enhancement|nmod|END_ENTITY	Direct electron transfer enhancement of covalently bound tyrosinase to glassy_carbon via Woodward 's reagent K .
14975587	0	glatiramer_acetate	72,90	IL-10	13,18	glatiramer acetate	IL-10	MESH:C089995	25325(Tax:10116)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of IL-10 in rat peritoneal macrophages and dendritic cells by glatiramer_acetate .
16083971	0	glatiramer_acetate	88,106	brain-derived_neurotrophic_factor	6,39	glatiramer acetate	brain-derived neurotrophic factor	MESH:C089995	627	Chemical	Gene	reversal|nmod|START_ENTITY END_ENTITY|dep|reversal	Lower brain-derived_neurotrophic_factor in serum of relapsing remitting MS : reversal by glatiramer_acetate .
17439900	0	glatiramer_acetate	118,136	brain-derived_neurotrophic_factor	14,47	glatiramer acetate	brain-derived neurotrophic factor	MESH:C089995	627	Chemical	Gene	treated|nmod|START_ENTITY Production|acl|treated Production|nmod|END_ENTITY	Production of brain-derived_neurotrophic_factor by mononuclear cells of patients with multiple_sclerosis treated with glatiramer_acetate , interferon-beta 1a , and high doses of immunoglobulins .
24938775	0	glatiramer_acetate	10,28	brain-derived_neurotrophic_factor	49,82	glatiramer acetate	brain-derived neurotrophic factor	MESH:C089995	627	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of glatiramer_acetate on peripheral blood brain-derived_neurotrophic_factor and phosphorylated TrkB levels in relapsing-remitting multiple_sclerosis .
11687463	0	glatiramer_acetate	137,155	urokinase_plasminogen_activator_receptor	14,54	glatiramer acetate	urokinase plasminogen activator receptor	MESH:C089995	5329	Chemical	Gene	effect|nmod|START_ENTITY Expression|dep|effect Expression|nmod|END_ENTITY	Expression of urokinase_plasminogen_activator_receptor on monocytes from patients with relapsing-remitting_multiple_sclerosis : effect of glatiramer_acetate -LRB- copolymer 1 -RRB- .
1493225	0	glibenclamide	52,65	CA1	73,76	glibenclamide	CA1	MESH:D005905	310218(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|neurones neurones|compound|END_ENTITY	Adenosine-induced hyperpolarization is depressed by glibenclamide in rat CA1 neurones .
10191357	0	glibenclamide	67,80	CFTR	53,57	glibenclamide	CFTR	MESH:D005905	12638(Tax:10090)	Chemical	Gene	sensitivity|amod|START_ENTITY confers|dobj|sensitivity confers|nsubj|Cystic_fibrosis_transmembrane_conductance_regulator Cystic_fibrosis_transmembrane_conductance_regulator|appos|END_ENTITY	Cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- confers glibenclamide sensitivity to outwardly rectifying chloride channel -LRB- ORCC -RRB- in Hi-5 insect cells .
17582383	0	glibenclamide	19,32	CFTR	0,4	glibenclamide	CFTR	MESH:D005905	1080	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	CFTR inhibition by glibenclamide requires a positive charge in cytoplasmic loop three .
9306276	11	glibenclamide	915,928	CFTR	945,949	glibenclamide	CFTR	MESH:D005905	12638(Tax:10090)	Chemical	Gene	site|amod|START_ENTITY identify|dobj|site identify|nmod|END_ENTITY	To begin to identify the glibenclamide binding site in CFTR , we investigated whether glibenclamide competes with either MgATP or Cl - ions for a common binding site .
9306276	11	glibenclamide	975,988	CFTR	945,949	glibenclamide	CFTR	MESH:D005905	12638(Tax:10090)	Chemical	Gene	competes|nsubj|START_ENTITY investigated|ccomp|competes investigated|advcl|begin begin|xcomp|identify identify|nmod|END_ENTITY	To begin to identify the glibenclamide binding site in CFTR , we investigated whether glibenclamide competes with either MgATP or Cl - ions for a common binding site .
8842604	0	glibenclamide	62,75	Glucagon-like_peptide_I	0,23	glibenclamide	Glucagon-like peptide I	MESH:D005905	171528(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY enhances|dobj|effect enhances|nsubj|END_ENTITY	Glucagon-like_peptide_I enhances the insulinotropic effect of glibenclamide in NIDDM patients and in the perfused rat pancreas .
97083	0	glibenclamide	95,108	Insulin	0,7	glibenclamide	Insulin	MESH:D005905	3630	Chemical	Gene	START_ENTITY|nsubj|secretion secretion|compound|END_ENTITY	Insulin secretion in growth_hormone-deficient children and the effect of the sulfonylurea drug glibenclamide on linear growth .
10968114	0	glibenclamide	89,102	insulin	126,133	glibenclamide	insulin	MESH:D005905	3630	Chemical	Gene	treated|nmod|START_ENTITY diabetes|acl|treated women|nmod|diabetes outcome|nmod|women comparison|nmod|outcome treated|nsubj|comparison treated|nmod|END_ENTITY	A comparison between the pregnancy outcome of women with gestation diabetes treated with glibenclamide and those treated with insulin .
11344200	0	glibenclamide	80,93	insulin	143,150	glibenclamide	insulin	MESH:D005905	3630	Chemical	Gene	effect|nmod|START_ENTITY potentiates|dep|effect potentiates|dep|evidence evidence|nmod|effect effect|nmod|extraction extraction|compound|END_ENTITY	Glucose-dependent_insulinotropic_hormone potentiates the hypoglycemic effect of glibenclamide in healthy volunteers : evidence for an effect on insulin extraction .
115730	0	glibenclamide	14,27	insulin	45,52	glibenclamide	insulin	MESH:D005905	3630	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|responses responses|compound|END_ENTITY	The effect of glibenclamide treatment on the insulin and glucagon responses to oral glucose and galactose in maturity onset diabetics .
14715864	0	glibenclamide	26,39	insulin	4,11	glibenclamide	insulin	MESH:D005905	3630	Chemical	Gene	secretagogues|amod|START_ENTITY secretagogues|compound|END_ENTITY	The insulin secretagogues glibenclamide and repaglinide do not influence growth hormone secretion in humans but stimulate glucagon secretion during profound insulin_deficiency .
15270789	0	glibenclamide	38,51	insulin	55,62	glibenclamide	insulin	MESH:D005905	3630	Chemical	Gene	START_ENTITY|nmod|sensitivity sensitivity|compound|END_ENTITY	Sustained effects of pioglitazone vs. glibenclamide on insulin sensitivity , glycaemic control , and lipid profiles in patients with Type 2 diabetes .
16873786	0	glibenclamide	125,138	insulin	102,109	glibenclamide	insulin	MESH:D005905	3630	Chemical	Gene	study|nmod|START_ENTITY study|acl|compare compare|dobj|profile profile|nmod|END_ENTITY	An open , randomized , parallel-group study to compare the efficacy and safety profile of inhaled human insulin -LRB- Exubera -RRB- with glibenclamide as adjunctive therapy in patients with type 2 diabetes poorly controlled on metformin .
1904820	0	glibenclamide	34,47	insulin	16,23	glibenclamide	insulin	MESH:D005905	3630	Chemical	Gene	effect|nmod|START_ENTITY effect|compound|END_ENTITY	Extrapancreatic insulin effect of glibenclamide .
1904820	4	glibenclamide	575,588	insulin	644,651	glibenclamide	insulin	MESH:D005905	3630	Chemical	Gene	able|nsubj|START_ENTITY able|xcomp|maintain maintain|dobj|increase increase|nmod|levels levels|compound|END_ENTITY	It is concluded that glibenclamide is able to maintain a more prolonged increase in serum insulin levels by inhibiting the degradation of insulin in the vascular endothelial cells of the liver .
1906584	0	glibenclamide	38,51	insulin	16,23	glibenclamide	insulin	MESH:D005905	3630	Chemical	Gene	combined|nmod|START_ENTITY combined|csubj|-LSB- -LSB-|dobj|effects effects|nmod|END_ENTITY	-LSB- The effects of insulin combined with glibenclamide on glucose and lipid metabolism in patients with Type_II_diabetes_mellitus -RSB- .
26269444	0	glibenclamide	106,119	insulin	59,66	glibenclamide	insulin	MESH:D005905	3630	Chemical	Gene	-RSB-|amod|START_ENTITY stimulated|nmod|-RSB- cells|acl|stimulated amyloid|nmod|cells amyloid|nmod|secretion secretion|compound|END_ENTITY	-LSB- The effects and mechanism of islet amyloid polypeptide on insulin secretion in INS-1 cells stimulated by glibenclamide -RSB- .
3084315	0	glibenclamide	10,23	insulin	77,84	glibenclamide	insulin	MESH:D005905	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of glibenclamide in insulin-treated diabetic patients with a residual insulin secretion .
3092851	0	glibenclamide	28,41	insulin	53,60	glibenclamide	insulin	MESH:D005905	3630	Chemical	Gene	verapamil|nmod|START_ENTITY Effect|nmod|verapamil stimulated|nsubj|Effect stimulated|dobj|secretion secretion|compound|END_ENTITY	Effect of oral verapamil on glibenclamide stimulated insulin secretion .
3140992	0	glibenclamide	15,28	insulin	42,49	glibenclamide	insulin	MESH:D005905	3630	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|secretion secretion|compound|END_ENTITY	The effects of glibenclamide treatment on insulin secretion and on insulin binding to erythrocytes in type_II_diabetes_mellitus .
3141755	0	glibenclamide	18,31	insulin	35,42	glibenclamide	insulin	MESH:D005905	3630	Chemical	Gene	START_ENTITY|nmod|requirements requirements|compound|END_ENTITY	Lack of effect of glibenclamide on insulin requirements and diabetic control in persons with insulin-dependent_diabetes .
3919531	0	glibenclamide	65,78	insulin	158,165	glibenclamide	insulin	MESH:D005905	3630	Chemical	Gene	effect|appos|START_ENTITY controlled|nsubj|effect controlled|nmod|END_ENTITY	Transient effect of the combination of insulin and sulfonylurea -LRB- glibenclamide -RRB- on glycemic control in non-insulin dependent diabetics poorly controlled with insulin alone .
3919531	0	glibenclamide	65,78	insulin	39,46	glibenclamide	insulin	MESH:D005905	3630	Chemical	Gene	effect|appos|START_ENTITY effect|nmod|combination combination|nmod|END_ENTITY	Transient effect of the combination of insulin and sulfonylurea -LRB- glibenclamide -RRB- on glycemic control in non-insulin dependent diabetics poorly controlled with insulin alone .
3934860	0	glibenclamide	112,125	insulin	26,33	glibenclamide	insulin	MESH:D005905	3630	Chemical	Gene	treatment|nmod|START_ENTITY treatment|nmod|diabetics diabetics|amod|dependent dependent|advmod|END_ENTITY	-LSB- Combination treatment of insulin dependent elderly diabetics -LRB- type_II_diabetes -RRB- with the sulfonylurea compound glibenclamide -RSB- .
8378743	0	glibenclamide	5,18	insulin	46,53	glibenclamide	insulin	MESH:D005905	3630	Chemical	Gene	influence|nsubj|START_ENTITY influence|dobj|clearance clearance|nmod|uptake uptake|compound|END_ENTITY	Does glibenclamide influence the clearance of insulin and glucose uptake in patients with type_2_diabetes_mellitus ?
8846678	0	glibenclamide	98,111	insulin	68,75	glibenclamide	insulin	MESH:D005905	3630	Chemical	Gene	diabetes_mellitus|amod|START_ENTITY addition|nmod|diabetes_mellitus dosage|nmod|addition dosage|compound|END_ENTITY	More uniform diurnal blood glucose control and a reduction in daily insulin dosage on addition of glibenclamide to insulin in type 1 diabetes_mellitus : role of enhanced insulin sensitivity .
9545119	7	glibenclamide	1209,1222	insulin	1229,1236	glibenclamide	insulin	MESH:D005905	3630	Chemical	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	If patients rested after administration of glibenclamide serum insulin levels rose and remained elevated .
18831351	0	glibenclamide	121,134	leptin	28,34	glibenclamide	leptin	MESH:D005905	3952	Chemical	Gene	Relationship|nmod|START_ENTITY Relationship|nmod|END_ENTITY	Relationship between plasma leptin and plasma insulin levels in type-2 diabetic patients before and after treatment with glibenclamide and glimepiride .
16848726	0	glibenclamide	65,78	mucin	14,19	glibenclamide	mucin	MESH:D005905	65202(Tax:10116)	Chemical	Gene	Evaluation|nmod|START_ENTITY Evaluation|nmod|END_ENTITY	Evaluation of mucin as a release enhancer for rectal delivery of glibenclamide .
136374	0	glibornuride	27,39	insulin	7,14	glibornuride	insulin	MESH:C073323	3630	Chemical	Gene	START_ENTITY|nsubj|response response|compound|END_ENTITY	Plasma insulin response to glibornuride in thyrotoxicosis .
18541345	0	gliclazide	41,51	CYP2C9	18,24	gliclazide	CYP2C9	MESH:D005907	1559	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|nmod|END_ENTITY	The metabolism of CYP2C9 and CYP2C19 for gliclazide by homology modeling and docking study .
20831536	0	gliclazide	98,108	CYP2C9	13,19	gliclazide	CYP2C9	MESH:D005907	1559	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY polymorphisms|nmod|pharmacokinetics polymorphisms|nsubj|Influence Influence|nmod|END_ENTITY	Influence of CYP2C9 and CYP2C19 genetic polymorphisms on pharmacokinetics and pharmacodynamics of gliclazide in healthy Chinese Han volunteers .
3595434	0	gliclazide	13,23	GIP	59,62	gliclazide	GIP	MESH:D005907	2695	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	No effect of gliclazide on gastric inhibitory polypeptide -LRB- GIP -RRB- in type_II_diabetes .
1936478	0	gliclazide	65,75	NIDD	96,100	gliclazide	NIDD	MESH:D005907	254887	Chemical	Gene	START_ENTITY|nmod|treatment treatment|nmod|END_ENTITY	Comparative three-month study of the efficacies of metformin and gliclazide in the treatment of NIDD .
17022850	0	gliclazide	10,20	adiponectin	41,52	gliclazide	adiponectin	MESH:D005907	9370	Chemical	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	Effect of gliclazide modified release on adiponectin , interleukin-6 , and tumor_necrosis_factor-alpha plasma levels in individuals with type_2_diabetes_mellitus .
11853362	0	gliclazide	50,60	glucose_transporter_1	14,35	gliclazide	glucose transporter 1	MESH:D005907	24778(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of glucose_transporter_1 expression by gliclazide in rat L6 myoblasts .
11473038	0	gliclazide	55,65	insulin	87,94	gliclazide	insulin	MESH:D005907	3630	Chemical	Gene	sulfonylurea|appos|START_ENTITY administration|nmod|sulfonylurea increases|nsubj|administration increases|dobj|secretion secretion|compound|END_ENTITY	Acute and short-term administration of a sulfonylurea -LRB- gliclazide -RRB- increases pulsatile insulin secretion in type 2 diabetes .
14632720	0	gliclazide	30,40	insulin	73,80	gliclazide	insulin	MESH:D005907	3630	Chemical	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|END_ENTITY	Comparison of repaglinide vs. gliclazide in combination with bedtime NPH insulin in patients with Type 2 diabetes inadequately controlled with oral hypoglycaemic agents .
1794269	0	gliclazide	20,30	insulin	44,51	gliclazide	insulin	MESH:D005907	3630	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|release release|compound|END_ENTITY	Effect of 6 months ' gliclazide treatment on insulin release and sensitivity to endogenous insulin in NIDDM : role of initial CSII-induced normoglycemia .
1794269	0	gliclazide	20,30	insulin	90,97	gliclazide	insulin	MESH:D005907	3630	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|END_ENTITY	Effect of 6 months ' gliclazide treatment on insulin release and sensitivity to endogenous insulin in NIDDM : role of initial CSII-induced normoglycemia .
18394931	0	gliclazide	109,119	insulin	7,14	gliclazide	insulin	MESH:D005907	3630	Chemical	Gene	treated|nmod|START_ENTITY patients|acl|treated abolished|nmod|patients abolished|nsubjpass|response response|compound|END_ENTITY	Normal insulin response to short-term intense exercise is abolished in Type 2 diabetic patients treated with gliclazide .
18715212	0	gliclazide	14,24	insulin	30,37	gliclazide	insulin	MESH:D005907	3630	Chemical	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|END_ENTITY	Comparison of gliclazide with insulin as initial treatment modality in newly diagnosed type 2 diabetes .
1872303	0	gliclazide	18,28	insulin	146,153	gliclazide	insulin	MESH:D005907	3630	Chemical	Gene	treatment|compound|START_ENTITY Effect|nmod|treatment Effect|dep|role role|nmod|normoglycemia normoglycemia|compound|END_ENTITY	Effect of 6-month gliclazide treatment on insulin release and sensitivity to endogenous insulin in NIDDM : role of initial continuous subcutaneous insulin infusion-induced normoglycemia .
1872303	0	gliclazide	18,28	insulin	42,49	gliclazide	insulin	MESH:D005907	3630	Chemical	Gene	treatment|compound|START_ENTITY treatment|nmod|release release|compound|END_ENTITY	Effect of 6-month gliclazide treatment on insulin release and sensitivity to endogenous insulin in NIDDM : role of initial continuous subcutaneous insulin infusion-induced normoglycemia .
1872303	0	gliclazide	18,28	insulin	88,95	gliclazide	insulin	MESH:D005907	3630	Chemical	Gene	treatment|compound|START_ENTITY Effect|nmod|treatment Effect|nmod|END_ENTITY	Effect of 6-month gliclazide treatment on insulin release and sensitivity to endogenous insulin in NIDDM : role of initial continuous subcutaneous insulin infusion-induced normoglycemia .
6373160	0	gliclazide	22,32	insulin	46,53	gliclazide	insulin	MESH:D005907	3630	Chemical	Gene	treatment|compound|START_ENTITY treatment|nmod|secretion secretion|compound|END_ENTITY	Effect of middle-term gliclazide treatment on insulin secretion in non-insulin dependent diabetics .
17022850	0	gliclazide	10,20	interleukin-6	54,67	gliclazide	interleukin-6	MESH:D005907	3569	Chemical	Gene	release|amod|START_ENTITY release|amod|END_ENTITY	Effect of gliclazide modified release on adiponectin , interleukin-6 , and tumor_necrosis_factor-alpha plasma levels in individuals with type_2_diabetes_mellitus .
17118480	0	gliclazide	77,87	sulfonylurea_receptor_1	15,38	gliclazide	sulfonylurea receptor 1	MESH:D005907	6833	Chemical	Gene	genotype|xcomp|START_ENTITY genotype|nsubj|Association Association|nmod|END_ENTITY	Association of sulfonylurea_receptor_1 genotype with therapeutic response to gliclazide in type 2 diabetes .
12832345	0	glimepiride	10,21	adiponectin	31,42	glimepiride	adiponectin	MESH:C057619	9370	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|level level|compound|END_ENTITY	Effect of glimepiride on serum adiponectin level in subjects with type 2 diabetes .
12568204	0	glimepiride	52,63	insulin	15,22	glimepiride	insulin	MESH:C057619	3630	Chemical	Gene	dose|nmod|START_ENTITY Immunoreactive|nmod|dose Immunoreactive|dobj|response response|compound|END_ENTITY	Immunoreactive insulin response to a single dose of glimepiride in lean type 2 diabetic subjects .
14996518	0	glimepiride	11,22	insulin	26,33	glimepiride	insulin	MESH:C057619	3630	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Effects of glimepiride on insulin secretion and sensitivity in patients with recently diagnosed type_2_diabetes_mellitus .
15029102	0	glimepiride	35,46	insulin	50,57	glimepiride	insulin	MESH:C057619	3630	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Repaglinide is more efficient than glimepiride on insulin secretion and post-prandial glucose excursions in patients with type 2 diabetes .
16406190	0	glimepiride	24,35	insulin	58,65	glimepiride	insulin	MESH:C057619	3630	Chemical	Gene	efficacy|nmod|START_ENTITY metformin|nsubj|efficacy metformin|nmod|END_ENTITY	Comparative efficacy of glimepiride and/or metformin with insulin in type 2 diabetes .
16538000	0	glimepiride	12,23	insulin	27,34	glimepiride	insulin	MESH:C057619	3630	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	Efficacy of glimepiride on insulin resistance , adipocytokines , and atherosclerosis .
16958825	0	glimepiride	64,75	insulin	79,86	glimepiride	insulin	MESH:C057619	3630	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Pharmacokinetic and pharmacodynamic modelling of the effects of glimepiride on insulin secretion and glucose lowering in healthy humans .
19728131	0	glimepiride	10,21	insulin	47,54	glimepiride	insulin	MESH:C057619	493804(Tax:9685)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of glimepiride and nateglinide on serum insulin and glucose concentration in healthy cats .
21067837	0	glimepiride	16,27	insulin	46,53	glimepiride	insulin	MESH:C057619	3630	Chemical	Gene	START_ENTITY|nmod|therapy therapy|compound|END_ENTITY	Contribution of glimepiride to basal-prandial insulin therapy in patients with type 2 diabetes .
7662219	0	glipizide	15,24	Insulin	0,7	glipizide	Insulin	MESH:D005913	3630	Chemical	Gene	START_ENTITY|nsubj|versus versus|compound|END_ENTITY	Insulin versus glipizide treatment in patients with non-insulin-dependent_diabetes_mellitus .
17300595	0	glipizide	106,115	dipeptidyl_peptidase-4	27,49	glipizide	dipeptidyl peptidase-4	MESH:D005913	1803	Chemical	Gene	START_ENTITY|nsubj|Efficacy Efficacy|nmod|inhibitor inhibitor|amod|END_ENTITY	Efficacy and safety of the dipeptidyl_peptidase-4 inhibitor , sitagliptin , compared with the sulfonylurea , glipizide , in patients with type 2 diabetes inadequately controlled on metformin alone : a randomized , double-blind , non-inferiority trial .
1541320	0	glipizide	21,30	insulin	34,41	glipizide	insulin	MESH:D005913	3630	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Long-term effects of glipizide on insulin secretion and blood_glucose control in patients with non-insulin-dependent_diabetes_mellitus .
1585076	0	glipizide	10,19	insulin	29,36	glipizide	insulin	MESH:D005913	493804(Tax:9685)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of glipizide on serum insulin and glucose concentrations in healthy cats .
3047519	0	glipizide	14,23	insulin	41,48	glipizide	insulin	MESH:D005913	3630	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of glipizide on extraction of insulin by the human cirrhotic and noncirrhotic liver .
3318259	0	glipizide	16,25	insulin	171,178	glipizide	insulin	MESH:D005913	3630	Chemical	Gene	patients|amod|START_ENTITY addition|nmod|patients useful|nsubj|addition useful|nmod|presence presence|nmod|secretion secretion|compound|END_ENTITY	The addition of glipizide to insulin therapy in type-II diabetic patients with secondary failure to sulfonylureas is useful only in the presence of a significant residual insulin secretion .
3318259	0	glipizide	16,25	insulin	29,36	glipizide	insulin	MESH:D005913	3630	Chemical	Gene	START_ENTITY|nmod|therapy therapy|compound|END_ENTITY	The addition of glipizide to insulin therapy in type-II diabetic patients with secondary failure to sulfonylureas is useful only in the presence of a significant residual insulin secretion .
3319648	0	glipizide	41,50	insulin	137,144	glipizide	insulin	MESH:D005913	3630	Chemical	Gene	sulphonylurea|appos|START_ENTITY effect|nmod|sulphonylurea Lack|nmod|effect Lack|dep|diabetics diabetics|nmod|secretion secretion|compound|END_ENTITY	Lack of primary effect of sulphonylurea -LRB- glipizide -RRB- on plasma lipoproteins and insulin action in former type 2 diabetics with attenuated insulin secretion .
3322723	0	glipizide	10,19	insulin	23,30	glipizide	insulin	MESH:D005913	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of glipizide on insulin secretion and insulin metabolism in obese type II diabetic patients .
6369970	0	glipizide	10,19	insulin	61,68	glipizide	insulin	MESH:D005913	3630	Chemical	Gene	treatment|amod|START_ENTITY Effect|nmod|treatment Effect|nmod|aspects aspects|nmod|END_ENTITY	Effect of glipizide treatment on various aspects of glucose , insulin , and lipid metabolism in patients with noninsulin-dependent_diabetes_mellitus .
6392057	5	glipizide	545,554	insulin	583,590	glipizide	insulin	MESH:D005913	3630	Chemical	Gene	cells|nmod|START_ENTITY incubation|nmod|cells found|nmod|incubation found|ccomp|binding binding|nsubj|increase increase|nmod|receptor receptor|compound|END_ENTITY	After a 24-hour preliminary incubation of cells with glipizide , we found a 44 % increase of insulin receptor binding apparently due to an increase of insulin binding sites .
23305140	0	gliptin	29,36	DPP-IV	52,58	gliptin	DPP-IV	null	1803	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	3D QSAR and docking study of gliptin derivatives as DPP-IV inhibitors .
8394949	0	globotriaosyl_ceramide	30,52	Gb3	54,57	globotriaosyl ceramide	Gb3	MESH:C018549	53947	Chemical	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	-LSB- Immunohistochemical study of globotriaosyl_ceramide -LRB- Gb3 -RRB- in testicular_tumors -RSB- .
7657808	0	globotriaosylceramide	27,48	Shiga-like_toxin_1	54,72	globotriaosylceramide	Shiga-like toxin 1	MESH:C018549	55850	Chemical	Gene	START_ENTITY|appos|receptor receptor|compound|END_ENTITY	Maturational regulation of globotriaosylceramide , the Shiga-like_toxin_1 receptor , in cultured human gut epithelial cells .
15305225	0	glucocorticosteroids	46,66	11beta-hydroxysteroid_dehydrogenase_type_2	70,112	glucocorticosteroids	11beta-hydroxysteroid dehydrogenase type 2	null	3291	Chemical	Gene	START_ENTITY|nmod|overexpression overexpression|amod|END_ENTITY	Impairment of the antiproliferative effect of glucocorticosteroids by 11beta-hydroxysteroid_dehydrogenase_type_2 overexpression in MCF-7 breast-cancer cells .
20095806	0	glucocorticosteroids	31,51	IL-6	75,79	glucocorticosteroids	IL-6	null	3569	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Long-term effect of high doses glucocorticosteroids on mRNA expression for IL-6 and IL-8 in relapsed multiple_sclerosis patients .
14637141	0	glucopyranosylidene-spiro-thiohydantoin	46,85	salivary_alpha-amylase	20,42	glucopyranosylidene-spiro-thiohydantoin	salivary alpha-amylase	MESH:C452302	276	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of human salivary_alpha-amylase by glucopyranosylidene-spiro-thiohydantoin .
12135767	0	glucosamine	25,36	GLUT2	0,5	glucosamine	GLUT2	MESH:D005944	6514	Chemical	Gene	transporter|amod|START_ENTITY transporter|nsubj|END_ENTITY	GLUT2 is a high affinity glucosamine transporter .
21440571	0	glucosamine	22,33	Glucokinase	0,11	glucosamine	Glucokinase	MESH:D005944	24385(Tax:10116)	Chemical	Gene	stimulates|compound|START_ENTITY stimulates|amod|END_ENTITY	Glucokinase inhibitor glucosamine stimulates feeding and activates hypothalamic neuropeptide_Y and orexin neurons .
22966296	0	glucosamine	50,61	IL-6	19,23	glucosamine	IL-6	MESH:D005944	3569	Chemical	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|nmod|END_ENTITY	Down-regulation of IL-6 , IL-8 , TNF-a and IL-1b by glucosamine in HaCaT cells , but not in the presence of TNF-a There is considerable evidence that glucosamine exerts an inhibitory effect on inflammatory cytokine expression in cells .
17498959	0	glucosamine	9,20	MMP-2	30,35	glucosamine	MMP-2	MESH:D005944	4313	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expressions expressions|amod|END_ENTITY	Sulfated glucosamine inhibits MMP-2 and MMP-9 expressions in human fibrosarcoma cells .
8359840	0	glucosamine	78,89	Prolactin	0,9	glucosamine	Prolactin	MESH:D005944	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|suppression suppression|compound|END_ENTITY	Prolactin suppression during pre and post-implantation periods on rat uterine glucosamine synthase activity .
1231993	0	glucosamine	11,22	insulin	26,33	glucosamine	insulin	MESH:D005944	483665(Tax:9615)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of glucosamine on insulin and glucagon secretion in dogs and ducks .
2158304	0	glucosamine	9,20	insulin	71,78	glucosamine	insulin	MESH:D005944	3630	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|effects effects|nmod|END_ENTITY	Mannose , glucosamine and inositol_monophosphate inhibit the effects of insulin on lipogenesis .
21466783	0	glucosamine	5,16	transforming_growth_factor_b1	41,70	glucosamine	transforming growth factor b1	MESH:D005944	59086(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Oral glucosamine increases expression of transforming_growth_factor_b1 -LRB- TGFb1 -RRB- and connective_tissue_growth_factor -LRB- CTGF -RRB- mRNA in rat cartilage and kidney : implications for human efficacy and toxicity .
19655169	0	glucosamine	52,63	transglutaminase_2	17,35	glucosamine	transglutaminase 2	MESH:D005944	7052	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	The mechanism of transglutaminase_2 inhibition with glucosamine : implications of a possible anti-inflammatory effect through transglutaminase inhibition .
8083170	0	glucosamine-1-phosphate	18,41	acetyltransferase	42,59	glucosamine-1-phosphate	acetyltransferase	MESH:C038515	20468107	Chemical	Gene	activities|amod|START_ENTITY activities|amod|END_ENTITY	Copurification of glucosamine-1-phosphate acetyltransferase and N-acetylglucosamine-1-phosphate uridyltransferase activities of Escherichia_coli : characterization of the glmU gene product as a bifunctional enzyme catalyzing two subsequent steps in the pathway for UDP-N-acetylglucosamine synthesis .
3872921	0	glucosamine-6-phosphate	37,60	epidermal_growth_factor	10,33	glucosamine-6-phosphate	epidermal growth factor	MESH:C001293	13645(Tax:10090)	Chemical	Gene	activity|amod|START_ENTITY Effect|nmod|activity Effect|nmod|END_ENTITY	Effect of epidermal_growth_factor on glucosamine-6-phosphate synthetase activity in the colon of neonatal mice .
22476244	0	glucosamine_sulfate	11,30	leptin	61,67	glucosamine sulfate	leptin	MESH:D005944	3952	Chemical	Gene	therapy|compound|START_ENTITY therapy|nmod|levels levels|compound|END_ENTITY	Effects of glucosamine_sulfate and exercise therapy on serum leptin levels in patients with knee_osteoarthritis : preliminary results of randomized controlled clinical trial .
15161861	0	glucosaminyl	27,39	GCNT2	71,76	glucosaminyl	GCNT2	null	2651	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A nonsense mutation in the glucosaminyl -LRB- N-acetyl -RRB- transferase 2 gene -LRB- GCNT2 -RRB- : association with autosomal_recessive_congenital_cataracts .
22848385	0	glucose	37,44	A2b_adenosine_receptor	4,26	glucose	A2b adenosine receptor	MESH:D005947	11541(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY modulates|dobj|homeostasis modulates|nsubj|END_ENTITY	The A2b_adenosine_receptor modulates glucose homeostasis and obesity .
22982378	0	glucose	66,73	ABCB4	44,49	glucose	ABCB4	MESH:D005947	18670(Tax:10090)	Chemical	Gene	modulator|nmod|START_ENTITY END_ENTITY|nmod|modulator	The hepatic phosphatidylcholine transporter ABCB4 as modulator of glucose homeostasis .
18583231	0	glucose	6,13	ABCG1	25,30	glucose	ABCG1	MESH:D005947	9619	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	-LSB- High glucose suppresses ABCG1 expression by increasing oxidative stress and inducing nuclear_factor-kappaB activation in vascular smooth muscle cells -RSB- .
22315310	5	glucose	760,767	ABCG1	707,712	glucose	ABCG1	MESH:D005947	11307(Tax:10090)	Chemical	Gene	levels|compound|START_ENTITY resulted|nmod|levels resulted|nsubj|Lack Lack|nmod|END_ENTITY	Lack of both ABCG1 and b-cell ABCA1 resulted in increased fasting glucose levels and a greater impairment in glucose_tolerance compared with either ABCG1 deletion or loss of ABCA1 in b-cells alone .
7649171	0	glucose	101,108	ACS2	0,4	glucose	ACS2	MESH:D005947	850846(Tax:4932)	Chemical	Gene	essential|nmod|START_ENTITY essential|nsubj|END_ENTITY	ACS2 , a Saccharomyces_cerevisiae gene encoding acetyl-coenzyme_A synthetase , essential for growth on glucose .
24740569	0	glucose	14,21	ADCY5	0,5	glucose	ADCY5	MESH:D005947	111	Chemical	Gene	couples|dobj|START_ENTITY couples|nsubj|END_ENTITY	ADCY5 couples glucose to insulin secretion in human islets .
21163859	0	glucose	32,39	AKT	84,87	glucose	AKT	MESH:D005947	11651(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY regulates|dobj|metabolism regulates|nmod|activation activation|compound|END_ENTITY	Acid_sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression .
21953448	0	glucose	93,100	AKT	254,257	glucose	AKT	MESH:D005947	207	Chemical	Gene	utilization|compound|START_ENTITY utilization|acl|inhibiting inhibiting|dobj|protein protein|appos|END_ENTITY	Hydrogen_sulfide and L-cysteine increase phosphatidylinositol_3 ,4,5 - trisphosphate -LRB- PIP3 -RRB- and glucose utilization by inhibiting phosphatase and tensin homolog -LRB- PTEN -RRB- protein and activating phosphoinositide_3-kinase -LRB- PI3K -RRB- / serine/threonine protein kinase -LRB- AKT -RRB- / protein kinase C / -LRB- PKC / -RRB- in 3T3l1 adipocytes .
22131882	11	glucose	1848,1855	AKT	1801,1804	glucose	AKT	MESH:D005947	207	Chemical	Gene	homeostasis|compound|START_ENTITY interfering|nmod|homeostasis prevent|advcl|interfering prevent|dobj|activation activation|compound|END_ENTITY	Insulin-mediated activation of AKT is unaffected by DNA-PK inhibitor treatment , suggesting that this effect is restricted to DNA damage-mediated activation of AKT and that , clinically , DNA-PK inhibition might prevent platinum-induced AKT activation without interfering with normal glucose homeostasis , an unwanted toxicity of direct AKT inhibitors .
25931147	0	glucose	36,43	AKT	72,75	glucose	AKT	MESH:D005947	11651(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY homeostasis|acl|linking linking|dobj|pathways pathways|compound|END_ENTITY	Genetic ablation of PRAS40 improves glucose homeostasis via linking the AKT and mTOR pathways .
11007965	0	glucose	67,74	AMP-activated_protein_kinase	0,28	glucose	AMP-activated protein kinase	MESH:D005947	78975(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY counteracted|dobj|effect counteracted|nsubj|END_ENTITY	AMP-activated_protein_kinase counteracted the inhibitory effect of glucose on the phosphoenolpyruvate_carboxykinase gene expression in rat hepatocytes .
11117997	0	glucose	14,21	AMP-activated_protein_kinase	35,63	glucose	AMP-activated protein kinase	MESH:D005947	78975(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY transport|nmod|END_ENTITY	Activation of glucose transport by AMP-activated_protein_kinase via stimulation of nitric_oxide_synthase .
11546797	0	glucose	15,22	AMP-activated_protein_kinase	36,64	glucose	AMP-activated protein kinase	MESH:D005947	78975(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY transport|nmod|END_ENTITY	Stimulation of glucose transport by AMP-activated_protein_kinase via activation of p38_mitogen-activated_protein_kinase .
12502487	0	glucose	35,42	AMP-activated_protein_kinase	77,105	glucose	AMP-activated protein kinase	MESH:D005947	5563	Chemical	Gene	glycogen_synthase|nmod|START_ENTITY Regulation|nmod|glycogen_synthase Regulation|dep|role role|nmod|END_ENTITY	Regulation of glycogen_synthase by glucose and glycogen : a possible role for AMP-activated_protein_kinase .
15242807	0	glucose	90,97	AMP-activated_protein_kinase	33,61	glucose	AMP-activated protein kinase	MESH:D005947	78975(Tax:10116)	Chemical	Gene	responsiveness|compound|START_ENTITY impairs|dobj|responsiveness impairs|nsubj|stimulation stimulation|nmod|END_ENTITY	Metformin-induced stimulation of AMP-activated_protein_kinase in beta-cells impairs their glucose responsiveness and can lead to apoptosis .
15294031	0	glucose	14,21	AMP-activated_protein_kinase	39,67	glucose	AMP-activated protein kinase	MESH:D005947	5563	Chemical	Gene	transport|compound|START_ENTITY Regulation|nmod|transport Regulation|nmod|END_ENTITY	Regulation of glucose transport by the AMP-activated_protein_kinase .
15561925	0	glucose	46,53	AMP-activated_protein_kinase	0,28	glucose	AMP-activated protein kinase	MESH:D005947	5564	Chemical	Gene	sensor|compound|START_ENTITY END_ENTITY|dep|sensor	AMP-activated_protein_kinase : a new beta-cell glucose sensor ?
16816404	0	glucose	146,153	AMP-activated_protein_kinase	63,91	glucose	AMP-activated protein kinase	MESH:D005947	78975(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY inhibits|dobj|uptake inhibits|nsubj|phosphorylation phosphorylation|amod|END_ENTITY	5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside-induced AMP-activated_protein_kinase phosphorylation inhibits basal and insulin-stimulated glucose uptake , lipid synthesis , and fatty_acid oxidation in isolated rat adipocytes .
16822958	0	glucose	51,58	AMP-activated_protein_kinase	0,28	glucose	AMP-activated protein kinase	MESH:D005947	5563	Chemical	Gene	transport|compound|START_ENTITY regulation|nmod|transport regulation|amod|END_ENTITY	AMP-activated_protein_kinase and the regulation of glucose transport .
16870829	0	glucose	35,42	AMP-activated_protein_kinase	60,88	glucose	AMP-activated protein kinase	MESH:D005947	5562	Chemical	Gene	Potentiation|nmod|START_ENTITY transport|nsubj|Potentiation transport|nmod|END_ENTITY	Potentiation of insulin-stimulated glucose transport by the AMP-activated_protein_kinase .
17530314	0	glucose	36,43	AMP-activated_protein_kinase	69,97	glucose	AMP-activated protein kinase	MESH:D005947	78975(Tax:10116)	Chemical	Gene	independent|compound|START_ENTITY independent|nmod|END_ENTITY	Alpha-lipoic_acid increases cardiac glucose oxidation independent of AMP-activated_protein_kinase in isolated working rat hearts .
17689496	0	glucose	47,54	AMP-activated_protein_kinase	76,104	glucose	AMP-activated protein kinase	MESH:D005947	78975(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY stimulates|dobj|uptake stimulates|nmod|activation activation|appos|END_ENTITY	CAPE -LRB- caffeic_acid_phenethyl_ester -RRB- stimulates glucose uptake through AMPK -LRB- AMP-activated_protein_kinase -RRB- activation in skeletal muscle cells .
18992226	0	glucose	41,48	AMP-activated_protein_kinase	106,134	glucose	AMP-activated protein kinase	MESH:D005947	5563	Chemical	Gene	metabolism|compound|START_ENTITY beta-sitosterol|nmod|metabolism effects|nmod|beta-sitosterol mediated|nsubjpass|effects mediated|nmod|END_ENTITY	Beneficial effects of beta-sitosterol on glucose and lipid metabolism in L6 myotube cells are mediated by AMP-activated_protein_kinase .
19073152	0	glucose	117,124	AMP-activated_protein_kinase	73,101	glucose	AMP-activated protein kinase	MESH:D005947	5563	Chemical	Gene	transport|compound|START_ENTITY transport|amod|END_ENTITY	A newly synthetic chromium_complex-chromium -LRB- D-phenylalanine -RRB- 3 activates AMP-activated_protein_kinase and stimulates glucose transport .
19261894	0	glucose	14,21	AMP-activated_protein_kinase	62,90	glucose	AMP-activated protein kinase	MESH:D005947	5563	Chemical	Gene	Regulation|nmod|START_ENTITY transporter|nsubj|Regulation transporter|nmod|tolerance tolerance|amod|END_ENTITY	Regulation of glucose transporter 3 surface expression by the AMP-activated_protein_kinase mediates tolerance to glutamate excitation in neurons .
20118562	0	glucose	35,42	AMP-activated_protein_kinase	58,86	glucose	AMP-activated protein kinase	MESH:D005947	5563	Chemical	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Ginsenoside_Rg1 suppresses hepatic glucose production via AMP-activated_protein_kinase in HepG2 cells .
20217115	0	glucose	137,144	AMP-activated_protein_kinase	7,35	glucose	AMP-activated protein kinase	MESH:D005947	5563	Chemical	Gene	ingestion|compound|START_ENTITY influence|nmod|ingestion phosphorylation|dep|influence phosphorylation|amod|END_ENTITY	SIRT1 , AMP-activated_protein_kinase phosphorylation and downstream kinases in response to a single bout of sprint exercise : influence of glucose ingestion .
20231899	0	glucose	69,76	AMP-activated_protein_kinase	26,54	glucose	AMP-activated protein kinase	MESH:D005947	5563	Chemical	Gene	uptake|compound|START_ENTITY signaling|nmod|uptake END_ENTITY|acl|signaling	Phospholipase_D1 mediates AMP-activated_protein_kinase signaling for glucose uptake .
20409939	0	glucose	47,54	AMP-activated_protein_kinase	70,98	glucose	AMP-activated protein kinase	MESH:D005947	78975(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY blockade|nmod|metabolism Effects|nmod|blockade Effects|nmod|END_ENTITY	Effects of angiotensin II receptor blockade on glucose metabolism via AMP-activated_protein_kinase in insulin-resistant hypertensive rats .
20682691	0	glucose	52,59	AMP-activated_protein_kinase	13,41	glucose	AMP-activated protein kinase	MESH:D005947	78975(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	Hypothalamic AMP-activated_protein_kinase regulates glucose production .
22952994	0	glucose	21,28	AMP-activated_protein_kinase	70,98	glucose	AMP-activated protein kinase	MESH:D005947	5563	Chemical	Gene	uptake|compound|START_ENTITY stimulates|dobj|uptake stimulates|nmod|activation activation|nmod|END_ENTITY	BMS309403 stimulates glucose uptake in myotubes through activation of AMP-activated_protein_kinase .
24815694	0	glucose	60,67	AMP-activated_protein_kinase	14,42	glucose	AMP-activated protein kinase	MESH:D005947	5563	Chemical	Gene	regulation|compound|START_ENTITY mediates|dobj|regulation mediates|nsubj|complex complex|amod|END_ENTITY	The mammalian AMP-activated_protein_kinase complex mediates glucose regulation of gene expression in the yeast Saccharomyces_cerevisiae .
25072399	0	glucose	19,26	AMP-activated_protein_kinase	56,84	glucose	AMP-activated protein kinase	MESH:D005947	5562	Chemical	Gene	consumption|compound|START_ENTITY consumption|nmod|activation activation|amod|END_ENTITY	Berberine promotes glucose consumption independently of AMP-activated_protein_kinase activation .
10329989	0	glucose	36,43	AMPK	10,14	glucose	AMPK	MESH:D005947	78975(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY activation|nmod|metabolism activation|nsubj|Effect Effect|nmod|END_ENTITY	Effect of AMPK activation on muscle glucose metabolism in conscious rats .
12006353	0	glucose	50,57	AMPK	14,18	glucose	AMPK	MESH:D005947	78975(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY essential|nmod|uptake essential|nsubj|Activation Activation|nmod|END_ENTITY	Activation of AMPK is essential for AICAR-induced glucose uptake by skeletal muscle but not adipocytes .
12839490	0	glucose	61,68	AMPK	42,46	glucose	AMPK	MESH:D005947	5563	Chemical	Gene	homoeostasis|compound|START_ENTITY kinase|nmod|homoeostasis kinase|appos|END_ENTITY	Roles of 5 ' - AMP-activated protein kinase -LRB- AMPK -RRB- in mammalian glucose homoeostasis .
14747282	0	glucose	42,49	AMPK	9,13	glucose	AMPK	MESH:D005947	78975(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY stimulation|nmod|transport END_ENTITY|dobj|stimulation	Ca2 + and AMPK both mediate stimulation of glucose transport by muscle contractions .
16489105	0	glucose	44,51	AMPK	0,4	glucose	AMPK	MESH:D005947	5563	Chemical	Gene	uptake|compound|START_ENTITY stimulation|nmod|uptake restores|dobj|stimulation restores|nsubj|activation activation|compound|END_ENTITY	AMPK activation restores the stimulation of glucose uptake in an in vitro model of insulin-resistant cardiomyocytes via the activation of protein_kinase_B .
16503364	0	glucose	35,42	AMPK	16,20	glucose	AMPK	MESH:D005947	78975(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY activation|nmod|metabolism activation|compound|END_ENTITY	Role of hepatic AMPK activation in glucose metabolism and dexamethasone-induced regulation of AMPK expression .
16503364	0	glucose	35,42	AMPK	94,98	glucose	AMPK	MESH:D005947	78975(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY activation|nmod|metabolism Role|nmod|activation Role|nmod|expression expression|compound|END_ENTITY	Role of hepatic AMPK activation in glucose metabolism and dexamethasone-induced regulation of AMPK expression .
17227964	0	glucose	42,49	AMPK	65,69	glucose	AMPK	MESH:D005947	5563	Chemical	Gene	uptake|compound|START_ENTITY alter|dobj|uptake alter|nmod|inhibition inhibition|compound|END_ENTITY	Ketone bodies alter dinitrophenol-induced glucose uptake through AMPK inhibition and oxidative stress generation in adult cardiomyocytes .
17689496	0	glucose	47,54	AMPK	70,74	glucose	AMPK	MESH:D005947	78975(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY stimulates|dobj|uptake stimulates|nmod|activation activation|compound|END_ENTITY	CAPE -LRB- caffeic_acid_phenethyl_ester -RRB- stimulates glucose uptake through AMPK -LRB- AMP-activated_protein_kinase -RRB- activation in skeletal muscle cells .
18178721	0	glucose	54,61	AMPK	31,35	glucose	AMPK	MESH:D005947	78975(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY increase|dobj|uptake increase|nsubj|activation activation|nmod|END_ENTITY	Ischemia-induced activation of AMPK does not increase glucose uptake in glycogen-replete isolated working rat hearts .
18701654	0	glucose	15,22	AMPK	71,75	glucose	AMPK	MESH:D005947	78975(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY Stimulation|nmod|transport Stimulation|nmod|pathways pathways|compound|END_ENTITY	Stimulation of glucose transport in response to activation of distinct AMPK signaling pathways .
19716700	0	glucose	91,98	AMPK	147,151	glucose	AMPK	MESH:D005947	5563	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|activation activation|nmod|END_ENTITY	Palbinone and triterpenes from Moutan Cortex -LRB- Paeonia suffruticosa , Paeoniaceae -RRB- stimulate glucose uptake and glycogen synthesis via activation of AMPK in insulin-resistant human HepG2 Cells .
20570724	0	glucose	113,120	AMPK	98,102	glucose	AMPK	MESH:D005947	5563	Chemical	Gene	uptake|compound|START_ENTITY role|dep|uptake role|nmod|_ _|appos|END_ENTITY	The pivotal role of protein_kinase_C_zeta _ -LRB- PKCzeta -RRB- in insulin - and AMP-activated_protein_kinase -LRB- AMPK -RRB- - mediated glucose uptake in muscle cells .
20633632	0	glucose	57,64	AMPK	99,103	glucose	AMPK	MESH:D005947	5564	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|activation activation|compound|END_ENTITY	Selected compounds derived from Moutan Cortex stimulated glucose uptake and glycogen synthesis via AMPK activation in human HepG2 cells .
20966509	5	glucose	708,715	AMPK	738,742	glucose	AMPK	MESH:D005947	5563	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|response response|nmod|activation activation|compound|END_ENTITY	Interestingly , increased glucose uptake in response to AMPK activation may occur in an insulin-independent manner .
21602475	0	glucose	107,114	AMPK	91,95	glucose	AMPK	MESH:D005947	5563	Chemical	Gene	uptake|compound|START_ENTITY involved|nmod|uptake involved|nmod|effect effect|nmod|END_ENTITY	Inhibition of the mTOR/p70S6K pathway is not involved in the insulin-sensitizing effect of AMPK on cardiac glucose uptake .
22306011	0	glucose	24,31	AMPK	48,52	glucose	AMPK	MESH:D005947	5562	Chemical	Gene	START_ENTITY|dobj|consumption consumption|nmod|END_ENTITY	p-Synephrine stimulates glucose consumption via AMPK in L6 skeletal muscle cells .
22796442	0	glucose	59,66	AMPK	17,21	glucose	AMPK	MESH:D005947	5563	Chemical	Gene	uptake|amod|START_ENTITY role|nmod|uptake activity|dep|role activity|compound|END_ENTITY	Exercise-induced AMPK activity in skeletal muscle : role in glucose uptake and insulin sensitivity .
23159620	0	glucose	117,124	AMPK	151,155	glucose	AMPK	MESH:D005947	5562	Chemical	Gene	concentration|compound|START_ENTITY dependence|nmod|concentration dependence|nmod|END_ENTITY	Metformin inhibition of mTORC1 activation , DNA synthesis and proliferation in pancreatic_cancer cells : dependence on glucose concentration and role of AMPK .
23432097	0	glucose	55,62	AMPK	98,102	glucose	AMPK	MESH:D005947	5563	Chemical	Gene	metabolism|compound|START_ENTITY regulates|dobj|metabolism regulates|advcl|activating activating|dobj|pathways pathways|compound|END_ENTITY	Rosemary -LRB- Rosmarinus officinalis L. -RRB- extract regulates glucose and lipid metabolism by activating AMPK and PPAR pathways in HepG2 cells .
23958199	0	glucose	199,206	AMPK	73,77	glucose	AMPK	MESH:D005947	5563	Chemical	Gene	uptake|compound|START_ENTITY promoting|dobj|uptake gingerol|advcl|promoting -LSB-|parataxis|gingerol -LSB-|parataxis|enhances enhances|nmod|activation activation|nmod|END_ENTITY	-LRB- S -RRB- - -LSB- 6 -RSB- - Gingerol enhances glucose uptake in L6 myotubes by activation of AMPK in response to -LSB- Ca2 + -RSB- i. PURPOSE : The aim of this study was to investigate the mechanism of -LRB- S -RRB- - -LSB- 6 -RSB- - gingerol in promoting glucose uptake in L6 skeletal muscle cells .
23958199	0	glucose	26,33	AMPK	73,77	glucose	AMPK	MESH:D005947	5563	Chemical	Gene	uptake|compound|START_ENTITY enhances|dobj|uptake enhances|nmod|activation activation|nmod|END_ENTITY	-LRB- S -RRB- - -LSB- 6 -RSB- - Gingerol enhances glucose uptake in L6 myotubes by activation of AMPK in response to -LSB- Ca2 + -RSB- i. PURPOSE : The aim of this study was to investigate the mechanism of -LRB- S -RRB- - -LSB- 6 -RSB- - gingerol in promoting glucose uptake in L6 skeletal muscle cells .
24844367	0	glucose	40,47	AMPK	88,92	glucose	AMPK	MESH:D005947	78975(Tax:10116)	Chemical	Gene	homeostasis|compound|START_ENTITY improves|dobj|homeostasis improves|parataxis|involvement involvement|nmod|END_ENTITY	Short-term calorie restriction improves glucose homeostasis in old rats : involvement of AMPK .
25122003	0	glucose	57,64	AMPK	22,26	glucose	AMPK	MESH:D005947	78975(Tax:10116)	Chemical	Gene	disposal|compound|START_ENTITY pathways|dobj|disposal pathways|nsubj|END_ENTITY	Urocortin_3 activates AMPK and AKT pathways and enhances glucose disposal in rat skeletal muscle .
25500743	1	glucose	157,164	AMPK	188,192	glucose	AMPK	MESH:D005947	5562	Chemical	Gene	uncouple|compound|START_ENTITY Focus|nmod|uncouple END_ENTITY|nsubj|Focus	Focus on `` glucose and palmitate uncouple AMPK from autophagy in human aortic endothelial cells '' .
25842853	0	glucose	6,13	AMPK	97,101	glucose	AMPK	MESH:D005947	5563	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|communication communication|nmod|fibroblasts fibroblasts|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- High glucose promotes gap junctional communication in cultured neonatal cardiac fibroblasts via AMPK activation -RSB- .
26054749	13	glucose	1926,1933	AMPK	1876,1880	glucose	AMPK	MESH:D005947	78975(Tax:10116)	Chemical	Gene	exposed|nmod|START_ENTITY cardiomyocytes|acl|exposed Thr172|nmod|cardiomyocytes increased|nmod|Thr172 increased|dobj|phosphorylation phosphorylation|nmod|AMP-activated_protein_kinase AMP-activated_protein_kinase|appos|END_ENTITY	In addition , resveratrol significantly increased phosphorylation of AMP-activated_protein_kinase -LRB- AMPK -RRB- at Thr172 in cardiomyocytes exposed to high glucose .
26416883	0	glucose	5,12	AMPK	78,82	glucose	AMPK	MESH:D005947	5563	Chemical	Gene	starvation|compound|START_ENTITY induces|nsubj|starvation induces|dobj|H3K36me2 H3K36me2|acl|demethylation demethylation|nmod|END_ENTITY	Mild glucose starvation induces KDM2A-mediated H3K36me2 demethylation through AMPK to reduce rRNA transcription and cell proliferation .
26471090	0	glucose	100,107	AMPK	20,24	glucose	AMPK	MESH:D005947	5562	Chemical	Gene	uptake|compound|START_ENTITY gluconeogenesis|dobj|uptake gluconeogenesis|nsubj|END_ENTITY	Saponarin activates AMPK in a calcium-dependent manner and suppresses gluconeogenesis and increases glucose uptake via phosphorylation of CRTC2 and HDAC5 .
26585419	0	glucose	60,67	AMPK	0,4	glucose	AMPK	MESH:D005947	5563	Chemical	Gene	uptake|compound|START_ENTITY involved|nmod|uptake involved|nsubjpass|END_ENTITY	AMPK , a metabolic sensor , is involved in isoeugenol-induced glucose uptake in muscle cells .
23310952	0	glucose	10,17	AMPKa1	0,6	glucose	AMPKa1	MESH:D005947	5562	Chemical	Gene	sensor|compound|START_ENTITY END_ENTITY|dep|sensor	AMPKa1 : a glucose sensor that controls CD8 T-cell memory .
8932737	5	glucose	967,974	ANF	1014,1017	glucose	MCH	MESH:D005947	5367	Chemical	Gene	cortisol|dep|START_ENTITY cortisol|dep|END_ENTITY	Recordings of water intake -LRB- H2Oin -RRB- , urine volume -LRB- Uv -RRB- , urinary Na -LRB- UNaV -RRB- and K excretion -LRB- UKV -RRB- were made , as well as hematocrit , plasma Na , K , osmolality , protein , glucose , ACTH , vasopressin , renin , endothelin , ANF , cortisol and aldosterone concentrations .
25966080	0	glucose	89,96	AP-1	15,19	glucose	AP-1	MESH:D005947	3727	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of AP-1 in p38MAPK signaling pathway in osteoblast apoptosis induced by high glucose .
25777259	14	glucose	1574,1581	AQP3	1596,1600	glucose	AQP3	MESH:D005947	360	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	The ERK and PI3K/AKT signaling pathways were involved in high glucose regulation of AQP3 in human GC cells .
19726872	0	glucose	40,47	ATF4	25,29	glucose	ATF4	MESH:D005947	11911(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY regulates|dobj|metabolism regulates|nsubj|END_ENTITY	The transcription factor ATF4 regulates glucose metabolism in mice through its expression in osteoblasts .
22298775	0	glucose	69,76	ATF4	30,34	glucose	ATF4	MESH:D005947	468	Chemical	Gene	homeostasis|compound|START_ENTITY control|dobj|homeostasis cooperates|xcomp|control cooperates|nmod|protein protein|nummod|END_ENTITY	FoxO1 protein cooperates with ATF4 protein in osteoblasts to control glucose homeostasis .
24330582	0	glucose	72,79	ATF4	61,65	glucose	ATF4	MESH:D005947	468	Chemical	Gene	deprivation|compound|START_ENTITY induces|nmod|deprivation induces|nmod|END_ENTITY	An aryl_hydrocarbon_receptor induces VEGF expression through ATF4 under glucose deprivation in HepG2 .
21163859	0	glucose	32,39	Acid_sphingomyelinase	0,21	glucose	Acid sphingomyelinase	MESH:D005947	20597(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY regulates|dobj|metabolism regulates|nsubj|END_ENTITY	Acid_sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression .
21353883	0	glucose	11,18	Activin	0,7	glucose	Activin	MESH:D005947	83729	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	Activin in glucose metabolism .
12368907	0	glucose	23,30	Adiponectin	0,11	glucose	Adiponectin	MESH:D005947	9370	Chemical	Gene	utilization|compound|START_ENTITY stimulates|dobj|utilization stimulates|nsubj|END_ENTITY	Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase .
15634721	0	glucose	112,119	Adiponectin	0,11	glucose	Adiponectin	MESH:D005947	9370	Chemical	Gene	metabolism|compound|START_ENTITY related|nmod|metabolism related|nsubjpass|END_ENTITY	Adiponectin , leptin , and erythrocyte sodium/lithium countertransport activity , but not resistin , are related to glucose metabolism in growth_hormone-deficient adults .
15862282	0	glucose	90,97	Adiponectin	0,11	glucose	Adiponectin	MESH:D005947	9370	Chemical	Gene	tolerance|compound|START_ENTITY polycystic_ovary_syndrome|nmod|tolerance test|amod|polycystic_ovary_syndrome women|nmod|test levels|nmod|women levels|compound|END_ENTITY	Adiponectin and resistin serum levels in women with polycystic_ovary_syndrome during oral glucose tolerance test : a significant reciprocal correlation between adiponectin and resistin independent of insulin resistance indices .
16580118	0	glucose	72,79	Adiponectin	0,11	glucose	Adiponectin	MESH:D005947	9370	Chemical	Gene	challenge|compound|START_ENTITY women|nmod|challenge levels|nmod|women levels|compound|END_ENTITY	Adiponectin and glucose levels in women with negative or false positive glucose challenge test .
16752186	0	glucose	63,70	Adiponectin	0,11	glucose	Adiponectin	MESH:D005947	9370	Chemical	Gene	metabolism|compound|START_ENTITY regulation|nmod|metabolism implications|nmod|regulation END_ENTITY|dep|implications	Adiponectin in human pregnancy : implications for regulation of glucose and lipid metabolism .
17277888	0	glucose	29,36	Adiponectin	0,11	glucose	Adiponectin	MESH:D005947	9370	Chemical	Gene	decreases|dobj|START_ENTITY decreases|nsubj|END_ENTITY	Adiponectin decreases plasma glucose and improves insulin sensitivity in diabetic Swine .
18284435	0	glucose	88,95	Adiponectin	0,11	glucose	Adiponectin	MESH:D005947	9370	Chemical	Gene	metabolism|compound|START_ENTITY associated|nmod|metabolism associated|nsubjpass|END_ENTITY	Adiponectin and its response to thiazolidinediones are associated with insulin-mediated glucose metabolism in type 2 diabetic patients and their first-degree relatives .
19639497	0	glucose	46,53	Adiponectin	0,11	glucose	Adiponectin	MESH:D005947	9370	Chemical	Gene	load|compound|START_ENTITY concentrations|nmod|load concentrations|compound|END_ENTITY	Adiponectin and resistin concentrations after glucose load in adolescents with polycystic_ovary_syndrome .
20813965	0	glucose	19,26	Adiponectin	0,11	glucose	Adiponectin	MESH:D005947	9370	Chemical	Gene	production|compound|START_ENTITY lowers|dobj|production lowers|nsubj|END_ENTITY	Adiponectin lowers glucose production by increasing SOGA .
21299716	0	glucose	38,45	Adiponectin	0,11	glucose	Adiponectin	MESH:D005947	9370	Chemical	Gene	deprivation|compound|START_ENTITY survival|nmod|deprivation supports|dobj|survival supports|nsubj|END_ENTITY	Adiponectin supports cell survival in glucose deprivation through enhancement of autophagic response in colorectal_cancer cells .
21948177	0	glucose	98,105	Adiponectin	0,11	glucose	Adiponectin	MESH:D005947	9370	Chemical	Gene	level|nmod|START_ENTITY induced|nmod|level damages|acl|induced protects|nmod|damages protects|nsubj|END_ENTITY	Adiponectin protects endothelial cells from the damages induced by the intermittent high level of glucose .
22664643	0	glucose	79,86	Adiponectin	0,11	glucose	Adiponectin	MESH:D005947	9370	Chemical	Gene	induced|nmod|START_ENTITY reactive_oxygen_species|acl|induced generation|nmod|reactive_oxygen_species inhibits|dobj|generation inhibits|nsubj|END_ENTITY	Adiponectin inhibits the generation of reactive_oxygen_species induced by high glucose and promotes endothelial NO synthase formation in human mesangial cells .
23570346	0	glucose	73,80	Adiponectin	0,11	glucose	Adiponectin	MESH:D005947	9370	Chemical	Gene	status|compound|START_ENTITY regarding|dobj|status composition|xcomp|regarding composition|nsubj|complexes complexes|compound|END_ENTITY	Adiponectin complexes composition in Japanese-Brazilians regarding their glucose tolerance status .
23794410	0	glucose	52,59	Adiponectin	0,11	glucose	Adiponectin	MESH:D005947	9370	Chemical	Gene	uptake|compound|START_ENTITY maintains|dobj|uptake END_ENTITY|dep|maintains	Adiponectin to the rescue : how the embryo maintains glucose uptake in a diabetic mother .
24145125	0	glucose	56,63	AgRP	78,82	glucose	AgRP	MESH:D005947	181	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|synthesis synthesis|amod|END_ENTITY	Glucose sensing mechanisms in hypothalamic cell models : glucose inhibition of AgRP synthesis and secretion .
11311245	0	glucose	34,41	Akt	0,3	glucose	Akt	MESH:D005947	207	Chemical	Gene	uptake|compound|START_ENTITY induction|nmod|uptake mediates|dobj|induction mediates|nsubj|END_ENTITY	Akt mediates insulin induction of glucose uptake and up-regulation of GLUT4 gene expression in brown adipocytes .
12618235	0	glucose	5,12	Akt	102,105	glucose	Akt	MESH:D005947	24185(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|resistance resistance|dep|role role|nmod|activation activation|compound|END_ENTITY	High glucose induces cardiac_insulin-like_growth factor I resistance in ventricular myocytes : role of Akt and ERK activation .
12734207	0	glucose	73,80	Akt	19,22	glucose	Akt	MESH:D005947	11651(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY and_glucocorticoid-regulated_kinase|nmod|metabolism roles|dep|and_glucocorticoid-regulated_kinase roles|nmod|END_ENTITY	Differing roles of Akt and serum - _ and_glucocorticoid-regulated_kinase in glucose metabolism , DNA synthesis , and oncogenic activity .
16179343	0	glucose	42,49	Akt	65,68	glucose	Akt	MESH:D005947	11651(Tax:10090)	Chemical	Gene	changes|nmod|START_ENTITY regulate|nsubj|changes regulate|dobj|brain brain|amod|END_ENTITY	Physiological and pathological changes in glucose regulate brain Akt and glycogen_synthase_kinase-3 .
16306364	0	glucose	148,155	Akt	102,105	glucose	Akt	MESH:D005947	207	Chemical	Gene	disposal|compound|START_ENTITY associated|nmod|disposal associated|nsubjpass|insulin insulin|acl|signaling signaling|nmod|level level|nmod|END_ENTITY	Skeletal muscle insulin signaling defects downstream of phosphatidylinositol 3-kinase at the level of Akt are associated with impaired nonoxidative glucose disposal in HIV_lipodystrophy .
16352665	0	glucose	37,44	Akt	19,22	glucose	Akt	MESH:D005947	11651(Tax:10090)	Chemical	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Effects of chronic Akt activation on glucose uptake in the heart .
16679292	0	glucose	32,39	Akt	94,97	glucose	Akt	MESH:D005947	11651(Tax:10090)	Chemical	Gene	regulation|nmod|START_ENTITY metabolism|nsubj|regulation metabolism|nmod|phosphoinositide_3-kinase phosphoinositide_3-kinase|nmod|END_ENTITY	Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide_3-kinase via Akt and PKClambda/zeta .
16962100	0	glucose	69,76	Akt	106,109	glucose	Akt	MESH:D005947	207	Chemical	Gene	cells|amod|START_ENTITY cells|amod|uptake uptake|nmod|inhibition inhibition|nmod|END_ENTITY	Acetaldehyde promotes rapamycin-dependent activation of p70 -LRB- S6K -RRB- and glucose uptake despite inhibition of Akt and mTOR in dopaminergic SH-SY5Y human neuroblastoma cells .
18669636	0	glucose	139,146	Akt	7,10	glucose	Akt	MESH:D005947	207	Chemical	Gene	regulation|nmod|START_ENTITY Akt|nmod|regulation Use|dep|Akt Use|nmod|inhibitor inhibitor|compound|END_ENTITY	Use of Akt inhibitor and a drug-resistant mutant validates a critical role for protein_kinase_B / Akt in the insulin-dependent regulation of glucose and system A amino_acid uptake .
18669636	0	glucose	139,146	Akt	96,99	glucose	Akt	MESH:D005947	207	Chemical	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Use of Akt inhibitor and a drug-resistant mutant validates a critical role for protein_kinase_B / Akt in the insulin-dependent regulation of glucose and system A amino_acid uptake .
19647719	0	glucose	15,22	Akt	48,51	glucose	Akt	MESH:D005947	207	Chemical	Gene	concentration|compound|START_ENTITY influences|nsubj|concentration influences|xcomp|expression expression|nsubj|END_ENTITY	Long-term high glucose concentration influences Akt , ERK1/2 , and PTP1B protein expression in human aortic smooth muscle cells .
20139722	0	glucose	109,116	Akt	14,17	glucose	Akt	MESH:D005947	11651(Tax:10090)	Chemical	Gene	levels|compound|START_ENTITY effects|nmod|levels blocks|nmod|effects blocks|nsubj|inhibitor inhibitor|compound|END_ENTITY	An allosteric Akt inhibitor effectively blocks Akt signaling and tumor growth with only transient effects on glucose and insulin levels in vivo .
20139722	0	glucose	109,116	Akt	47,50	glucose	Akt	MESH:D005947	11651(Tax:10090)	Chemical	Gene	levels|compound|START_ENTITY effects|nmod|levels blocks|nmod|effects blocks|dobj|signaling signaling|compound|END_ENTITY	An allosteric Akt inhibitor effectively blocks Akt signaling and tumor growth with only transient effects on glucose and insulin levels in vivo .
20488185	0	glucose	106,113	Akt	71,74	glucose	Akt	MESH:D005947	24185(Tax:10116)	Chemical	Gene	resulting|nmod|START_ENTITY END_ENTITY|acl|resulting	Glyceraldehyde-3-phosphate_dehydrogenase interacts with phosphorylated Akt resulting from increased blood glucose in rat cardiac muscle .
20819080	0	glucose	22,29	Akt	0,3	glucose	Akt	MESH:D005947	207	Chemical	Gene	uptake|compound|START_ENTITY reduce|dobj|uptake inhibitors|xcomp|reduce inhibitors|nsubj|END_ENTITY	Akt inhibitors reduce glucose uptake independently of their effects on Akt .
20819080	0	glucose	22,29	Akt	71,74	glucose	Akt	MESH:D005947	207	Chemical	Gene	uptake|compound|START_ENTITY reduce|dobj|uptake reduce|nmod|END_ENTITY	Akt inhibitors reduce glucose uptake independently of their effects on Akt .
21218507	0	glucose	67,74	Akt	141,144	glucose	Akt	MESH:D005947	24185(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY exposure|nmod|uptake effects|nmod|exposure effects|dep|role role|nmod|pathway pathway|compound|END_ENTITY	Biphasic effects of chronic ethanol exposure on insulin-stimulated glucose uptake in primary cultured rat skeletal muscle cells : role of the Akt pathway and GLUT4 .
21348862	0	glucose	71,78	Akt	16,19	glucose	Akt	MESH:D005947	207	Chemical	Gene	metabolism|compound|START_ENTITY effects|nmod|metabolism specificity|dep|effects provide|dobj|specificity inhibitors|xcomp|provide inhibitors|nsubj|END_ENTITY	Next-generation Akt inhibitors provide greater specificity : effects on glucose metabolism in adipocytes .
21468601	0	glucose	48,55	Akt	124,127	glucose	Akt	MESH:D005947	207	Chemical	Gene	transport|compound|START_ENTITY transport|nmod|END_ENTITY	Knockdown of STEAP4 inhibits insulin-stimulated glucose transport and GLUT4 translocation via attenuated phosphorylation of Akt , independent of the effects of EEA1 .
21518696	0	glucose	33,40	Akt	66,69	glucose	Akt	MESH:D005947	24185(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|activation activation|nmod|END_ENTITY	Palmitic_acid acutely stimulates glucose uptake via activation of Akt and ERK1/2 in skeletal muscle cells .
22554284	0	glucose	179,186	Akt	0,3	glucose	Akt	MESH:D005947	207	Chemical	Gene	levels|nmod|START_ENTITY cultured|nmod|levels involved|advcl|cultured involved|nsubjpass|Cy Cy|compound|END_ENTITY	Akt and phospholipase Cy are involved in the regulation of growth and migration_of_MDA-MB-468_breast_cancer and SW480 colon_cancer cells when cultured with diabetogenic levels of glucose and insulin .
22674833	0	glucose	32,39	Akt	76,79	glucose	Akt	MESH:D005947	207	Chemical	Gene	uptake|compound|START_ENTITY stimulate|dobj|uptake stimulate|advcl|activating activating|dobj|END_ENTITY	Honokiol and magnolol stimulate glucose uptake by activating PI3K-dependent Akt in L6 myotubes .
22820890	0	glucose	35,42	Akt	110,113	glucose	Akt	MESH:D005947	207	Chemical	Gene	uptake|compound|START_ENTITY impaired|dobj|uptake ameliorates|acl|impaired ameliorates|parataxis|signaling signaling|nsubj|END_ENTITY	a-Lipoic_acid ameliorates impaired glucose uptake in LYRM1 overexpressing 3T3-L1 adipocytes through the IRS-1 / Akt signaling pathway .
23702482	0	glucose	23,30	Akt	98,101	glucose	Akt	MESH:D005947	207	Chemical	Gene	uptake|compound|START_ENTITY stimulates|dobj|uptake stimulates|nmod|activation activation|nmod|END_ENTITY	Chloroquine stimulates glucose uptake and glycogen synthase in muscle cells through activation of Akt .
24085037	0	glucose	54,61	Akt	83,86	glucose	Akt	MESH:D005947	24185(Tax:10116)	Chemical	Gene	uptake|nsubj|START_ENTITY uptake|advcl|modulating modulating|dobj|activity activity|compound|END_ENTITY	Mitochondrial_fragmentation_impairs insulin-dependent glucose uptake by modulating Akt activity through mitochondrial Ca2 + uptake .
24096870	0	glucose	55,62	Akt	89,92	glucose	Akt	MESH:D005947	207	Chemical	Gene	cell|nmod|START_ENTITY cell|nmod|activation activation|nmod|pathway pathway|compound|END_ENTITY	Metabolic regulation of cancer cell side population by glucose through activation of the Akt pathway .
24216610	0	glucose	67,74	Akt	0,3	glucose	Akt	MESH:D005947	11651(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY required|nmod|uptake required|nsubjpass|END_ENTITY	Akt and Rac1 signaling are jointly required for insulin-stimulated glucose uptake in skeletal muscle and downregulated in insulin resistance .
24694591	0	glucose	44,51	Akt	0,3	glucose	Akt	MESH:D005947	24185(Tax:10116)	Chemical	Gene	activation|nmod|START_ENTITY END_ENTITY|acl|activation	Akt and RhoA activation in response to high glucose require caveolin-1 phosphorylation in mesangial cells .
25310908	0	glucose	19,26	Akt	96,99	glucose	Akt	MESH:D005947	24185(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY improves|dobj|metabolism improves|advcl|activating activating|dobj|END_ENTITY	Polydatin improves glucose and lipid metabolism in experimental diabetes through activating the Akt signaling pathway .
25823386	0	glucose	26,33	Akt	104,107	glucose	Akt	MESH:D005947	11651(Tax:10090)	Chemical	Gene	tolerance|compound|START_ENTITY alleviates|dobj|tolerance alleviates|nmod|END_ENTITY	Licochalcone F alleviates glucose tolerance and chronic_inflammation in diet-induced obese mice through Akt and p38_MAPK .
26102565	0	glucose	40,47	Akt	62,65	glucose	Akt	MESH:D005947	207	Chemical	Gene	transport|compound|START_ENTITY transport|nmod|signaling signaling|compound|END_ENTITY	Aegeline from Aegle marmelos stimulates glucose transport via Akt and Rac1 signaling , and contributes to a cytoskeletal rearrangement through PI3K/Rac1 .
8940145	0	glucose	89,96	Akt	38,41	glucose	Akt	MESH:D005947	11651(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY adipocytes|dobj|uptake adipocytes|nsubj|Expression Expression|nmod|kinase kinase|compound|END_ENTITY	Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation .
9392506	0	glucose	9,16	Akt	55,58	glucose	Akt	MESH:D005947	24185(Tax:10116)	Chemical	Gene	tolerance|compound|START_ENTITY restores|nsubj|tolerance restores|dobj|activity activity|compound|END_ENTITY	Improved glucose tolerance restores insulin-stimulated Akt kinase activity and glucose transport in skeletal muscle from diabetic Goto-Kakizaki rats .
9632753	0	glucose	136,143	Akt	58,61	glucose	Akt	MESH:D005947	207	Chemical	Gene	transport|compound|START_ENTITY not|nmod|transport kinase|dep|not kinase|dobj|END_ENTITY	Requirement for activation of the serine-threonine kinase Akt -LRB- protein_kinase_B -RRB- in insulin stimulation of protein synthesis but not of glucose transport .
9819385	0	glucose	74,81	Akt	101,104	glucose	Akt	MESH:D005947	11651(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY stimulation|nmod|uptake clambda|nmod|stimulation kinase|dobj|clambda kinase|dep|not not|nmod|activation activation|compound|END_ENTITY	Requirement of atypical protein kinase clambda for insulin stimulation of glucose uptake but not for Akt activation in 3T3-L1 adipocytes .
16814735	0	glucose	85,92	Akt1	77,81	glucose	Akt1	MESH:D005947	207	Chemical	Gene	metabolism|compound|START_ENTITY roles|nmod|metabolism roles|nmod|END_ENTITY	siRNA-based gene silencing reveals specialized roles of IRS-1 / Akt2 and IRS-2 / Akt1 in glucose and lipid metabolism in human skeletal muscle .
17510697	0	glucose	82,89	Akt_substrate_of_160_kDa	8,32	glucose	Akt substrate of 160 kDa	MESH:D005947	9882	Chemical	Gene	transport|compound|START_ENTITY Role|nmod|transport Role|nmod|END_ENTITY	Role of Akt_substrate_of_160_kDa in insulin-stimulated and contraction-stimulated glucose transport .
12851327	0	glucose	79,86	Alpha-melanocyte-stimulating_hormone	0,36	glucose	Alpha-melanocyte-stimulating hormone	MESH:D005947	18976(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY regulator|nmod|metabolism regulator|nsubj|END_ENTITY	Alpha-melanocyte-stimulating_hormone is a peripheral , integrative regulator of glucose and fat metabolism .
1504107	0	glucose	35,42	Amylin	0,6	glucose	Amylin	MESH:D005947	15874(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY inhibits|dobj|uptake inhibits|nsubj|END_ENTITY	Amylin inhibits insulin-stimulated glucose uptake in C2C12 muscle cell line through a cholera-toxin-sensitive mechanism .
21939703	0	glucose	58,65	Amylin	0,6	glucose	Amylin	MESH:D005947	24476(Tax:10116)	Chemical	Gene	homeostasis|compound|START_ENTITY participating|nmod|homeostasis effect|acl|participating effect|compound|END_ENTITY	Amylin effect in extrapancreatic tissues participating in glucose homeostasis , in normal , insulin-resistant and type_2_diabetic state .
2261856	0	glucose	57,64	Amylin	0,6	glucose	Amylin	MESH:D005947	24476(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|END_ENTITY	Amylin release from perfused rat pancreas in response to glucose and arginine .
7774725	0	glucose	48,55	Amylin	0,6	glucose	Amylin	MESH:D005947	24476(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY effect|nmod|transport have|dobj|effect have|nsubj|END_ENTITY	Amylin and epinephrine have no direct effect on glucose transport in isolated rat soleus muscle .
8415669	0	glucose	27,34	Amylin	0,6	glucose	Amylin	MESH:D005947	15874(Tax:10090)	Chemical	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	Amylin modulates beta-cell glucose sensing via effects on stimulus-secretion coupling .
9212327	0	glucose	27,34	Amylin	0,6	glucose	Amylin	MESH:D005947	3375	Chemical	Gene	test|compound|START_ENTITY release|nmod|test release|nsubj|END_ENTITY	Amylin release during oral glucose tolerance test .
9458741	0	glucose	37,44	Amylin	0,6	glucose	Amylin	MESH:D005947	24476(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY influences|dobj|metabolism influences|nsubj|END_ENTITY	Amylin influences insulin-stimulated glucose metabolism by two independent mechanisms .
15837923	0	glucose	44,51	Angiopoietin-like_protein_4	0,27	glucose	Angiopoietin-like protein 4	MESH:D005947	57875(Tax:10090)	Chemical	Gene	decreases|dobj|START_ENTITY decreases|nsubj|END_ENTITY	Angiopoietin-like_protein_4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic_steatosis in mice .
15837923	0	glucose	65,72	Angiopoietin-like_protein_4	0,27	glucose	Angiopoietin-like protein 4	MESH:D005947	57875(Tax:10090)	Chemical	Gene	tolerance|compound|START_ENTITY decreases|dobj|tolerance decreases|nsubj|END_ENTITY	Angiopoietin-like_protein_4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic_steatosis in mice .
23387337	0	glucose	57,64	Angiopoietin-like_protein_4	0,27	glucose	Angiopoietin-like protein 4	MESH:D005947	51129	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Angiopoietin-like_protein_4 -LRB- ANGPTL4 -RRB- is induced by high glucose in retinal pigment epithelial cells and exhibits potent angiogenic activity on retinal endothelial cells .
11967010	0	glucose	88,95	Angiotensin_II	0,14	glucose	Angiotensin II	MESH:D005947	183	Chemical	Gene	altered|nmod|START_ENTITY altered|nsubjpass|activation activation|compound|END_ENTITY	Angiotensin_II activation of the JAK/STAT pathway in mesangial cells is altered by high glucose .
1400389	0	glucose	26,33	Angiotensin_II	0,14	glucose	Angiotensin II	MESH:D005947	24179(Tax:10116)	Chemical	Gene	activity|compound|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates glucose transport activity in cultured vascular smooth muscle cells .
17595220	0	glucose	128,135	Angiotensin_II	0,14	glucose	Angiotensin II	MESH:D005947	24179(Tax:10116)	Chemical	Gene	utilization|compound|START_ENTITY influencing|dobj|utilization stimulates|advcl|influencing stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates the reactivity of the pituitary-adrenal_axis in leptin-resistant Zucker rats , thereby influencing the glucose utilization .
17878754	0	glucose	25,32	Angiotensin_II	0,14	glucose	Angiotensin II	MESH:D005947	183	Chemical	Gene	uptake|compound|START_ENTITY decreases|dobj|uptake decreases|nsubj|END_ENTITY	Angiotensin_II decreases glucose uptake by downregulation of GLUT1 in the cell membrane of the vascular smooth muscle cell line A10 .
20409857	0	glucose	24,31	Angiotensin_II	0,14	glucose	Angiotensin II	MESH:D005947	24179(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY inhibits|dobj|uptake inhibits|nsubj|END_ENTITY	Angiotensin_II inhibits glucose uptake of skeletal muscle via the adenosine_monophosphate-activated protein kinase pathway .
20501681	0	glucose	54,61	Angiotensin_II	0,14	glucose	Angiotensin II	MESH:D005947	183	Chemical	Gene	disposal|compound|START_ENTITY enhances|dobj|disposal enhances|nsubj|END_ENTITY	Angiotensin_II enhances insulin-stimulated whole-body glucose disposal but impairs insulin-induced capillary recruitment in healthy volunteers .
21716329	0	glucose	70,77	Angiotensin_II	0,14	glucose	Angiotensin II	MESH:D005947	24179(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY signaling|nmod|metabolism insulin|acl|signaling shifts|dobj|insulin shifts|nsubj|END_ENTITY	Angiotensin_II shifts insulin signaling into vascular remodeling from glucose metabolism in vascular smooth muscle cells .
23104420	0	glucose	23,30	Angiotensin_II	0,14	glucose	Angiotensin II	MESH:D005947	24179(Tax:10116)	Chemical	Gene	utilization|compound|START_ENTITY impairs|dobj|utilization impairs|nsubj|END_ENTITY	Angiotensin_II impairs glucose utilization in obese Zucker rats by increasing HPA activity via an adrenal-dependent mechanism .
7900784	0	glucose	25,32	Angiotensin_II	0,14	glucose	Angiotensin II	MESH:D005947	24179(Tax:10116)	Chemical	Gene	uptake|nmod:npmod|START_ENTITY increases|dobj|uptake increases|nsubj|END_ENTITY	Angiotensin_II increases glucose uptake and glucose_transporter-1 mRNA levels in astroglia .
8349811	0	glucose	25,32	Angiotensin_II	0,14	glucose	Angiotensin II	MESH:D005947	183	Chemical	Gene	utilization|compound|START_ENTITY increases|dobj|utilization increases|nsubj|END_ENTITY	Angiotensin_II increases glucose utilization during acute hyperinsulinemia via a hemodynamic mechanism .
9931133	0	glucose	68,75	Angiotensin_II	0,14	glucose	Angiotensin II	MESH:D005947	183	Chemical	Gene	conditions|compound|START_ENTITY signaling|nmod|conditions END_ENTITY|acl|signaling	Angiotensin_II signaling in vascular smooth muscle cells under high glucose conditions .
19046574	0	glucose	18,25	Apelin	0,6	glucose	Apelin	MESH:D005947	30878(Tax:10090)	Chemical	Gene	utilization|compound|START_ENTITY stimulates|dobj|utilization stimulates|nsubj|END_ENTITY	Apelin stimulates glucose utilization in normal and obese insulin-resistant mice .
21062936	0	glucose	18,25	Apelin	0,6	glucose	Apelin	MESH:D005947	8862	Chemical	Gene	uptake|compound|START_ENTITY stimulates|dobj|uptake stimulates|nsubj|END_ENTITY	Apelin stimulates glucose uptake but not lipolysis in human adipose_tissue ex vivo .
21461612	0	glucose	18,25	Apelin	0,6	glucose	Apelin	MESH:D005947	8862	Chemical	Gene	uptake|compound|START_ENTITY stimulates|dobj|uptake stimulates|nsubj|END_ENTITY	Apelin stimulates glucose uptake through the PI3K/Akt pathway and improves insulin resistance in 3T3-L1 adipocytes .
23422767	9	glucose	1250,1257	Apelin	1128,1134	glucose	apelin	MESH:D005947	8862	Chemical	Gene	consumption|compound|START_ENTITY measured|nmod|consumption measured|nsubjpass|levels levels|compound|END_ENTITY	Apelin , visfatin , insulin and glucose levels were measured at baseline and 10 , 20 , 30 , 60 , 90 , 120 , 150 and 180 min after glucose consumption .
26565000	0	glucose	42,49	Apelin	0,6	glucose	Apelin	MESH:D005947	30878(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY control|dobj|metabolism targets|advcl|control targets|nsubj|END_ENTITY	Apelin targets gut contraction to control glucose metabolism via the brain .
26631739	0	glucose	35,42	Apelin	0,6	glucose	Apelin	MESH:D005947	58812(Tax:10116)	Chemical	Gene	homeostasis|compound|START_ENTITY controls|dobj|homeostasis controls|nsubj|END_ENTITY	Apelin controls fetal and neonatal glucose homeostasis and is altered by maternal undernutrition .
22619326	0	glucose	29,36	Apolipoprotein_A-IV	0,19	glucose	Apolipoprotein A-IV	MESH:D005947	11808(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY improves|dobj|homeostasis improves|nsubj|END_ENTITY	Apolipoprotein_A-IV improves glucose homeostasis by enhancing insulin secretion .
22228409	0	glucose	35,42	AtSUS2	14,20	glucose	AtSUS2	MESH:D005947	844347(Tax:3702)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of AtSUS2 and AtSUS3 by glucose and the transcription factor LEC2 in different tissues and at different stages of Arabidopsis seed development .
7963509	0	glucose	60,67	Atrial_natriuretic_factor	0,25	glucose	Atrial natriuretic factor	MESH:D005947	4878	Chemical	Gene	load|compound|START_ENTITY increases|nmod|load increases|nsubj|END_ENTITY	Atrial_natriuretic_factor increases in response to an acute glucose load .
22159910	0	glucose	77,84	B-type_natriuretic_peptide	0,26	glucose	B-type natriuretic peptide	MESH:D005947	4879	Chemical	Gene	affects|nmod|START_ENTITY affects|nsubj|END_ENTITY	B-type_natriuretic_peptide -LRB- BNP -RRB- affects the initial response to intravenous glucose : a randomised placebo-controlled cross-over study in healthy men .
12598908	0	glucose	80,87	BMP-9	71,76	glucose	BMP-9	MESH:D005947	2658	Chemical	Gene	homeostasis|compound|START_ENTITY END_ENTITY|nmod|homeostasis	An integrated functional genomics screening program reveals a role for BMP-9 in glucose homeostasis .
15704144	0	glucose	47,54	Beta-endorphin	0,14	glucose	Beta-endorphin	MESH:D005947	18976(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY decreases|dobj|uptake decreases|nsubj|END_ENTITY	Beta-endorphin decreases fatigue and increases glucose uptake independently in normal and dystrophic_mice .
1885266	0	glucose	78,85	Beta-endorphin	0,14	glucose	Beta-endorphin	MESH:D005947	5443	Chemical	Gene	load|compound|START_ENTITY plasma|nmod|load plasma|nsubj|END_ENTITY	Beta-endorphin plasma levels and their dependence on gender during an enteral glucose load in lean subjects as well as in obese patients before and after weight reduction .
2157655	0	glucose	69,76	Beta-endorphin	0,14	glucose	Beta-endorphin	MESH:D005947	5443	Chemical	Gene	tolerance|compound|START_ENTITY levels|nmod|tolerance test|nsubj|levels test|advmod|END_ENTITY	Beta-endorphin , insulin , ACTH and cortisol plasma levels during oral glucose tolerance test in obesity after weight_loss .
2951394	0	glucose	60,67	Beta-endorphin	0,14	glucose	Beta-endorphin	MESH:D005947	5443	Chemical	Gene	restores|nmod|START_ENTITY restores|nsubj|infusion infusion|amod|END_ENTITY	Beta-endorphin infusion restores acute insulin responses to glucose in type-2_diabetes_mellitus .
6323537	0	glucose	24,31	Beta-endorphin	0,14	glucose	Beta-endorphin	MESH:D005947	5443	Chemical	Gene	production|compound|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Beta-endorphin inhibits glucose production in the conscious dog .
9526708	0	glucose	32,39	Beta-endorphin	0,14	glucose	Beta-endorphin	MESH:D005947	5443	Chemical	Gene	tolerance|compound|START_ENTITY response|nmod|tolerance response|amod|END_ENTITY	Beta-endorphin response to oral glucose tolerance test in obese and non-obese pre - and postmenopausal women .
21757657	0	glucose	48,55	Bone_Gla_protein	0,16	glucose	Bone Gla protein	MESH:D005947	25295(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY increases|dobj|metabolism increases|nsubj|END_ENTITY	Bone_Gla_protein increases HIF-1alpha-dependent glucose metabolism and induces cartilage and vascular_calcification .
10973143	0	glucose	97,104	Bradykinin	0,10	glucose	Bradykinin	MESH:D005947	3827	Chemical	Gene	concentrations|compound|START_ENTITY presence|nmod|concentrations cells|nmod|presence activity|nmod|cells enhances|dobj|activity enhances|nsubj|END_ENTITY	Bradykinin enhances membrane electrical activity of pancreatic beta cells in the presence of low glucose concentrations .
9539311	0	glucose	42,49	Bradykinin	0,10	glucose	Bradykinin	MESH:D005947	478666(Tax:9615)	Chemical	Gene	uptake|compound|START_ENTITY potentiates|dobj|uptake potentiates|nsubj|END_ENTITY	Bradykinin potentiates insulin-stimulated glucose uptake and enhances insulin signal through the bradykinin B2 receptor in dog skeletal muscle and rat L6 myoblasts .
10868966	0	glucose	44,51	Brain-derived_neurotrophic_factor	0,33	glucose	Brain-derived neurotrophic factor	MESH:D005947	12064(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY regulates|dobj|metabolism regulates|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor regulates glucose metabolism by modulating energy balance in diabetic mice .
12112936	0	glucose	51,58	Brain-derived_neurotrophic_factor	0,33	glucose	Brain-derived neurotrophic factor	MESH:D005947	12064(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY regulates|dobj|metabolism regulates|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor -LRB- BDNF -RRB- regulates glucose and energy metabolism in diabetic mice .
12542722	0	glucose	112,119	Brain-derived_neurotrophic_factor	0,33	glucose	Brain-derived neurotrophic factor	MESH:D005947	12064(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY contribution|nmod|metabolism secretion|dep|contribution secretion|compound|END_ENTITY	Brain-derived_neurotrophic_factor modulates glucagon secretion from pancreatic alpha cells : its contribution to glucose metabolism .
17199719	0	glucose	43,50	Brain-derived_neurotrophic_factor	0,33	glucose	Brain-derived neurotrophic factor	MESH:D005947	12064(Tax:10090)	Chemical	Gene	utilization|compound|START_ENTITY enhances|dobj|utilization enhances|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor enhances glucose utilization in peripheral tissues of diabetic mice .
23080167	0	glucose	77,84	Brain-derived_neurotrophic_factor	0,33	glucose	Brain-derived neurotrophic factor	MESH:D005947	24225(Tax:10116)	Chemical	Gene	homeostasis|compound|START_ENTITY modulates|dobj|homeostasis modulates|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor in the nucleus tractus solitarii modulates glucose homeostasis after carotid chemoreceptor stimulation in rats .
9299565	0	glucose	48,55	Brain-derived_neurotrophic_factor	0,33	glucose	Brain-derived neurotrophic factor	MESH:D005947	12064(Tax:10090)	Chemical	Gene	level|compound|START_ENTITY reduces|dobj|level reduces|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor reduces blood glucose level in obese diabetic mice but not in normal mice .
8661938	0	glucose	18,25	C-2	5,8	glucose	C-2	MESH:D005947	717	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Only C-2 specific glucose oxidase activity is expressed in ligninolytic cultures of the white rot fungus Phanerochaete chrysosporium .
3882370	0	glucose	23,30	C-Peptide	0,9	glucose	C-Peptide	MESH:D005947	3630	Chemical	Gene	load|compound|START_ENTITY responses|nmod|load responses|amod|END_ENTITY	C-Peptide responses to glucose load in maturity-onset_diabetes_of_the_young -LRB- MODY -RRB- .
10189006	0	glucose	135,142	C-peptide	29,38	glucose	C-peptide	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY population|nmod|tolerance metabolic_syndrome-X|nmod|population markers|nmod|metabolic_syndrome-X fasting|nmod|markers fasting|dobj|END_ENTITY	Correlation of fasting serum C-peptide and insulin with markers of metabolic_syndrome-X in a homogenous Chinese population with normal glucose tolerance .
11436187	0	glucose	73,80	C-peptide	117,126	glucose	C-peptide	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY degrees|nmod|tolerance subjects|nmod|degrees phenotypes|nmod|subjects phenotypes|parataxis|using using|dobj|combination combination|nmod|rate rate|amod|END_ENTITY	Pathophysiologic phenotypes of Japanese subjects with varying degrees of glucose tolerance : using the combination of C-peptide secretion rate and minimal model analysis .
11556725	0	glucose	30,37	C-peptide	71,80	glucose	C-peptide	MESH:D005947	3630	Chemical	Gene	stimuli|compound|START_ENTITY rate|nmod|stimuli rate|dep|analyses analyses|nmod|data data|amod|END_ENTITY	Insulin secretion rate during glucose stimuli : alternative analyses of C-peptide data .
1569291	0	glucose	28,35	C-peptide	60,69	glucose	C-peptide	MESH:D005947	3630	Chemical	Gene	levels|compound|START_ENTITY levels|nmod|secretion secretion|amod|END_ENTITY	The effect of various blood glucose levels on post-glucagon C-peptide secretion in type 2 -LRB- non insulin-dependent -RRB- diabetes .
15754730	0	glucose	90,97	C-peptide	109,118	glucose	C-peptide	MESH:D005947	3630	Chemical	Gene	START_ENTITY|acl|stimulated stimulated|xcomp|END_ENTITY	Human resistin gene polymorphism is associated with visceral_obesity and fasting and oral glucose stimulated C-peptide in the Qu bec Family Study .
17965850	0	glucose	38,45	C-peptide	16,25	glucose	C-peptide	MESH:D005947	3630	Chemical	Gene	clearance|compound|START_ENTITY facilitates|dobj|clearance facilitates|nsubj|END_ENTITY	Metal-activated C-peptide facilitates glucose clearance and the release of a nitric_oxide stimulus via the GLUT1 transporter .
18389076	0	glucose	26,33	C-peptide	13,22	glucose	C-peptide	MESH:D005947	3630	Chemical	Gene	utilisation|compound|START_ENTITY Influence|nmod|utilisation Influence|nmod|END_ENTITY	Influence of C-peptide on glucose utilisation .
187365	0	glucose	31,38	C-peptide	18,27	glucose	C-peptide	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY END_ENTITY|nmod|tolerance	-LSB- Changes in serum C-peptide in glucose tolerance test ; with special reference to diabetes_and_insulinoma -RSB- .
21248305	0	glucose	122,129	C-peptide	27,36	glucose	C-peptide	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY degree|nmod|tolerance relationship|nmod|degree Shape|dep|relationship Shape|appos|curves curves|amod|END_ENTITY	Shape of glucose , insulin , C-peptide curves during a 3-h oral glucose tolerance test : any relationship with the degree of glucose tolerance ?
21248305	0	glucose	62,69	C-peptide	27,36	glucose	C-peptide	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY curves|nmod|test curves|amod|END_ENTITY	Shape of glucose , insulin , C-peptide curves during a 3-h oral glucose tolerance test : any relationship with the degree of glucose tolerance ?
21248305	0	glucose	9,16	C-peptide	27,36	glucose	C-peptide	MESH:D005947	3630	Chemical	Gene	Shape|nmod|START_ENTITY Shape|appos|curves curves|amod|END_ENTITY	Shape of glucose , insulin , C-peptide curves during a 3-h oral glucose tolerance test : any relationship with the degree of glucose tolerance ?
21415555	0	glucose	39,46	C-peptide	19,28	glucose	C-peptide	MESH:D005947	3630	Chemical	Gene	ratio|compound|START_ENTITY END_ENTITY|nmod|ratio	Postprandial serum C-peptide to plasma glucose ratio as a predictor of subsequent insulin treatment in patients with type 2 diabetes .
2190776	0	glucose	38,45	C-peptide	11,20	glucose	C-peptide	MESH:D005947	3630	Chemical	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Pancreatic C-peptide response to oral glucose in fibrocalculous_pancreatic_diabetes .
2229928	0	glucose	34,41	C-peptide	7,16	glucose	C-peptide	MESH:D005947	3630	Chemical	Gene	load|compound|START_ENTITY END_ENTITY|nmod|load	Plasma C-peptide response to oral glucose load in hyperthyroidism .
23831440	0	glucose	39,46	C-peptide	19,28	glucose	C-peptide	MESH:D005947	3630	Chemical	Gene	correlates|compound|START_ENTITY END_ENTITY|nmod|correlates	Postprandial serum C-peptide to plasma glucose concentration ratio correlates with oral glucose tolerance test - and glucose clamp-based disposition indexes .
23831440	0	glucose	88,95	C-peptide	19,28	glucose	C-peptide	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY correlates|nmod|test END_ENTITY|nmod|correlates	Postprandial serum C-peptide to plasma glucose concentration ratio correlates with oral glucose tolerance test - and glucose clamp-based disposition indexes .
25411619	0	glucose	26,33	C-peptide	13,22	glucose	C-peptide	MESH:D005947	3630	Chemical	Gene	ratio|compound|START_ENTITY END_ENTITY|nmod|ratio	Postprandial C-peptide to glucose ratio as a predictor of b-cell function and its usefulness for staged management of type 2 diabetes .
2693165	5	glucose	1052,1059	C-peptide	1080,1089	glucose	C-peptide	MESH:D005947	3630	Chemical	Gene	potentiation|compound|START_ENTITY potentiation|nmod|response response|amod|END_ENTITY	After glucagon injection , the relative glucose potentiation of the insulin response was significantly higher than the relative glucose potentiation of the C-peptide response at each level of hyperglycaemia -LRB- p less than 0.01 -RRB- .
2693165	5	glucose	964,971	C-peptide	1080,1089	glucose	C-peptide	MESH:D005947	3630	Chemical	Gene	potentiation|compound|START_ENTITY higher|nsubj|potentiation higher|nmod|potentiation potentiation|nmod|response response|amod|END_ENTITY	After glucagon injection , the relative glucose potentiation of the insulin response was significantly higher than the relative glucose potentiation of the C-peptide response at each level of hyperglycaemia -LRB- p less than 0.01 -RRB- .
2952415	0	glucose	19,26	C-peptide	84,93	glucose	C-peptide	MESH:D005947	3630	Chemical	Gene	loading|compound|START_ENTITY loading|nmod|stimuli stimuli|nmod|secretion secretion|amod|END_ENTITY	Comparison of oral glucose loading and intravenous glucagon injection as stimuli to C-peptide secretion in normal men .
3053748	0	glucose	110,117	C-peptide	76,85	glucose	C-peptide	MESH:D005947	3630	Chemical	Gene	administration|compound|START_ENTITY administration|amod|END_ENTITY	Peripheral insulin parallels changes in insulin secretion more closely than C-peptide after bolus intravenous glucose administration .
3323094	0	glucose	44,51	C-peptide	0,9	glucose	C-peptide	MESH:D005947	3630	Chemical	Gene	load|compound|START_ENTITY kinetics|nmod|load kinetics|amod|END_ENTITY	C-peptide kinetics following an intravenous glucose load in children undergoing regular hemodialysis .
3511350	0	glucose	61,68	C-peptide	28,37	glucose	C-peptide	MESH:D005947	3630	Chemical	Gene	affect|dobj|START_ENTITY affect|nsubj|Infusion Infusion|nmod|END_ENTITY	Infusion of synthetic human C-peptide does not affect plasma glucose , serum insulin , or plasma glucagon in healthy subjects .
3915258	0	glucose	38,45	C-peptide	11,20	glucose	C-peptide	MESH:D005947	3630	Chemical	Gene	loading|compound|START_ENTITY Serum|nmod|loading Serum|dobj|response response|amod|END_ENTITY	Serum free C-peptide response to oral glucose loading as a parameter for the monitoring of pancreatic B-cell function in diabetic patients .
499682	0	glucose	34,41	C-peptide	76,85	glucose	C-peptide	MESH:D005947	3630	Chemical	Gene	ingestion|compound|START_ENTITY rate|nmod|ingestion estimated|nsubj|rate estimated|nmod|output output|amod|END_ENTITY	Insulin production rate following glucose ingestion estimated by splanchnic C-peptide output in normal man .
6374968	0	glucose	50,57	C-peptide	22,31	glucose	C-peptide	MESH:D005947	3630	Chemical	Gene	load|compound|START_ENTITY free|nmod|load free|dobj|responses responses|amod|END_ENTITY	A study of serum free C-peptide responses to oral glucose load in diabetic patients : with special reference to types of diabetes and methods of treatment .
6695271	0	glucose	24,31	C-peptide	0,9	glucose	C-peptide	MESH:D005947	3630	Chemical	Gene	load|compound|START_ENTITY response|nmod|load response|amod|END_ENTITY	C-peptide response to a glucose load in young blacks and Indians with insulin-dependent_diabetes_mellitus .
7671552	0	glucose	83,90	C-peptide	0,9	glucose	C-peptide	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY comparison|nmod|test response|dep|comparison response|amod|END_ENTITY	C-peptide response to glucagon in type 2 diabetes_mellitus : a comparison with oral glucose tolerance test .
7677082	0	glucose	88,95	C-peptide	35,44	glucose	C-peptide	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY study|nmod|tolerance study|nmod|END_ENTITY	Population-based study of insulin , C-peptide , and blood pressure in Chinese with normal glucose tolerance .
8800366	0	glucose	49,56	C-peptide	10,19	glucose	C-peptide	MESH:D005947	3630	Chemical	Gene	utilization|compound|START_ENTITY Effect|nmod|utilization Effect|nmod|administration administration|amod|END_ENTITY	Effect of C-peptide administration on whole body glucose utilization in STZ-induced diabetic rats .
8800366	6	glucose	1369,1376	C-peptide	1316,1325	glucose	C-peptide	MESH:D005947	3630	Chemical	Gene	MCR|nmod|START_ENTITY increase|dobj|MCR increase|nsubj|END_ENTITY	In normal rats C-peptide did not significantly increase the MCR for glucose .
9133564	0	glucose	169,176	C-peptide	126,135	glucose	C-peptide	MESH:D005947	3630	Chemical	Gene	challenge|compound|START_ENTITY associated|nmod|challenge associated|nmod|END_ENTITY	A prevalent amino_acid polymorphism at codon 98 in the hepatocyte nuclear factor-1alpha gene is associated with reduced serum C-peptide and insulin responses to an oral glucose challenge .
9306037	0	glucose	135,142	C-peptide	89,98	glucose	C-peptide	MESH:D005947	3630	Chemical	Gene	glucose|nmod|START_ENTITY glucose|nmod|level level|compound|END_ENTITY	Differential effects of ambient blood glucose level and degree of obesity on basal serum C-peptide level and the C-peptide response to glucose and glucagon in non-insulin-dependent_diabetes_mellitus .
9306037	0	glucose	38,45	C-peptide	89,98	glucose	C-peptide	MESH:D005947	3630	Chemical	Gene	START_ENTITY|nmod|level level|compound|END_ENTITY	Differential effects of ambient blood glucose level and degree of obesity on basal serum C-peptide level and the C-peptide response to glucose and glucagon in non-insulin-dependent_diabetes_mellitus .
12421431	0	glucose	65,72	C-reactive_protein	0,18	glucose	C-reactive protein	MESH:D005947	1401	Chemical	Gene	related|nmod|START_ENTITY related|nsubj|END_ENTITY	C-reactive_protein is more strongly related to post-glucose load glucose than to fasting glucose in non-diabetic subjects ; the Insulin Resistance Atherosclerosis Study .
12421431	0	glucose	89,96	C-reactive_protein	0,18	glucose	C-reactive protein	MESH:D005947	1401	Chemical	Gene	fasting|dobj|START_ENTITY than|advcl|fasting related|advmod|than related|nsubj|END_ENTITY	C-reactive_protein is more strongly related to post-glucose load glucose than to fasting glucose in non-diabetic subjects ; the Insulin Resistance Atherosclerosis Study .
17279354	0	glucose	176,183	C-reactive_protein	0,18	glucose	C-reactive protein	MESH:D005947	1401	Chemical	Gene	transport|compound|START_ENTITY promotes|dobj|transport receptor|acl:relcl|promotes phosphorylation|nmod|receptor induces|dobj|phosphorylation induces|nsubj|END_ENTITY	C-reactive_protein induces phosphorylation of insulin receptor substrate-1 on Ser307 and Ser 612 in L6 myocytes , thereby impairing the insulin signalling pathway that promotes glucose transport .
17950110	0	glucose	83,90	C-reactive_protein	27,45	glucose	C-reactive protein	MESH:D005947	1401	Chemical	Gene	concentration|compound|START_ENTITY gluconeogenesis|dobj|concentration gluconeogenesis|nsubj|infusion infusion|nmod|increases increases|amod|END_ENTITY	A single bolus infusion of C-reactive_protein increases gluconeogenesis and plasma glucose concentration in humans .
18604320	0	glucose	18,25	C-reactive_protein	58,76	glucose	C-reactive protein	MESH:D005947	1401	Chemical	Gene	load|compound|START_ENTITY load|nmod|concentrations concentrations|nmod|END_ENTITY	-LSB- Effect of a high glucose load on serum concentrations of C-reactive_protein and alpha1-antitrypsin in obese women -RSB- .
18691271	0	glucose	99,106	C-reactive_protein	6,24	glucose	C-reactive protein	MESH:D005947	1401	Chemical	Gene	postload|dobj|START_ENTITY postload|nsubj|END_ENTITY	Serum C-reactive_protein -LRB- CRP -RRB- and microalbuminuria in relation to fasting and 2-h postload plasma glucose in a Chinese population .
19378424	0	glucose	83,90	C-reactive_protein	0,18	glucose	C-reactive protein	MESH:D005947	1401	Chemical	Gene	uptake|compound|START_ENTITY END_ENTITY|nmod|uptake	C-reactive_protein and tumor_necrosis_factor-alpha in relation to insulin-mediated glucose uptake , smoking and atherosclerosis .
21076541	0	glucose	126,133	C-reactive_protein	0,18	glucose	C-reactive protein	MESH:D005947	1401	Chemical	Gene	criteria|compound|START_ENTITY diagnosed|nmod|criteria diagnosed|nsubj|concentrations concentrations|amod|END_ENTITY	C-reactive_protein and gamma-glutamyltransferase concentrations in relation to the prevalence of type 2 diabetes diagnosed by glucose or HbA1c criteria in Chinese adults in Qingdao , China .
21948178	0	glucose	103,110	C-reactive_protein	56,74	glucose	C-reactive protein	MESH:D005947	1401	Chemical	Gene	tolerance|compound|START_ENTITY increases|nmod|tolerance increases|dobj|END_ENTITY	A hypertriglyceridemic state increases high sensitivity C-reactive_protein of Japanese men with normal glucose tolerance .
22273652	0	glucose	68,75	C-reactive_protein	106,124	glucose	C-reactive protein	MESH:D005947	25419(Tax:10116)	Chemical	Gene	levels|nmod|START_ENTITY Effect|appos|levels Effect|appos|END_ENTITY	Effect of daidzein-low-calorie diet on body weight , serum levels of glucose , resistin , and high sensitive C-reactive_protein in high fat , high calorie diet induced rats .
23069625	0	glucose	117,124	C-reactive_protein	0,18	glucose	C-reactive protein	MESH:D005947	12944(Tax:10090)	Chemical	Gene	delivery|compound|START_ENTITY inhibition|nmod|delivery causes|nmod|inhibition causes|nsubj|END_ENTITY	C-reactive_protein causes insulin resistance in mice through Fcy receptor IIB-mediated inhibition of skeletal muscle glucose delivery .
24326321	0	glucose	67,74	C-reactive_protein	15,33	glucose	C-reactive protein	MESH:D005947	1401	Chemical	Gene	levels|compound|START_ENTITY Association|nmod|levels Association|nmod|levels levels|amod|END_ENTITY	Association of C-reactive_protein levels with fasting and postload glucose levels according to glucose tolerance status .
24326321	0	glucose	95,102	C-reactive_protein	15,33	glucose	C-reactive protein	MESH:D005947	1401	Chemical	Gene	status|compound|START_ENTITY Association|nmod|status Association|nmod|levels levels|amod|END_ENTITY	Association of C-reactive_protein levels with fasting and postload glucose levels according to glucose tolerance status .
17047237	0	glucose	49,56	C5a	31,34	glucose	C5a	MESH:D005947	362119(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY roles|nmod|transport roles|nmod|END_ENTITY	The roles of complement factor C5a and CINC-1 in glucose transport , ultrafiltration , and neutrophil recruitment during peritoneal_dialysis .
24354619	0	glucose	41,48	CCCTC-binding_factor	0,20	glucose	CCCTC-binding factor	MESH:D005947	13018(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY mediates|dobj|effects mediates|nsubj|END_ENTITY	CCCTC-binding_factor mediates effects of glucose on beta cell survival .
24733189	0	glucose	5,12	CCL20	21,26	glucose	CCL20	MESH:D005947	20297(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	High glucose induces CCL20 in proximal tubular cells via activation of the KCa3 .1 channel .
22782897	0	glucose	29,36	CCL5	14,18	glucose	CCL5	MESH:D005947	6352	Chemical	Gene	uptake|compound|START_ENTITY regulates|dobj|uptake regulates|nsubj|END_ENTITY	The chemokine CCL5 regulates glucose uptake and AMP kinase signaling in activated T cells to facilitate chemotaxis .
18180316	0	glucose	5,12	CD14	52,56	glucose	CD14	MESH:D005947	929	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	High glucose enhances lipopolysaccharide-stimulated CD14 expression in U937 mononuclear cells by increasing nuclear_factor_kappaB and AP-1 activities .
7529289	0	glucose	56,63	CD14	88,92	glucose	CD14	MESH:D005947	929	Chemical	Gene	polymers|compound|START_ENTITY monocytes|nmod|polymers Activation|nmod|monocytes mediated|nsubjpass|Activation mediated|nmod|antigen antigen|compound|END_ENTITY	Activation of human monocytes by streptococcal rhamnose glucose polymers is mediated by CD14 antigen , and mannan binding protein inhibits TNF-alpha release .
26910838	0	glucose	31,38	CD226	0,5	glucose	CD226	MESH:D005947	10666	Chemical	Gene	uptake|compound|START_ENTITY reduces|dobj|uptake reduces|nsubj|END_ENTITY	CD226 reduces endothelial cell glucose uptake under hyperglycemic conditions with inflammation in type_2_diabetes_mellitus .
12121659	0	glucose	37,44	CD28	4,8	glucose	CD28	MESH:D005947	940	Chemical	Gene	metabolism|compound|START_ENTITY regulates|dobj|metabolism regulates|nsubj|END_ENTITY	The CD28 signaling pathway regulates glucose metabolism .
26336608	0	glucose	94,101	CD300LG	153,160	glucose	CD300LG	MESH:D005947	146894	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|nmod|END_ENTITY	Reduced CD300LG mRNA tissue expression , increased intramyocellular lipid content and impaired glucose metabolism in healthy male carriers of Arg82Cys in CD300LG : a novel genometabolic cross-link between CD300LG and common metabolic phenotypes .
18789673	0	glucose	84,91	CD36	20,24	glucose	CD36	MESH:D005947	948	Chemical	Gene	tolerance|compound|START_ENTITY subjects|nmod|tolerance liver_injury|nmod|subjects marker|nmod|liver_injury marker|csubj|Circulating Circulating|dobj|END_ENTITY	Circulating soluble CD36 is a novel marker of liver_injury in subjects with altered glucose tolerance .
19156623	0	glucose	44,51	CD36	20,24	glucose	CD36	MESH:D005947	948	Chemical	Gene	metabolism|compound|START_ENTITY associated|nmod|metabolism associated|csubj|Circulating Circulating|dobj|END_ENTITY	Circulating soluble CD36 is associated with glucose metabolism and interleukin-6 in glucose-intolerant men .
22869067	0	glucose	79,86	CD36	19,23	glucose	CD36	MESH:D005947	948	Chemical	Gene	fasting|dobj|START_ENTITY impaired|xcomp|fasting Association|acl|impaired Association|nmod|gene gene|compound|END_ENTITY	Association of the CD36 gene with impaired_glucose_tolerance , impaired fasting glucose , _ type-2_diabetes , _ and_lipid_metabolism in essential hypertensive patients .
26130608	0	glucose	69,76	CD36	98,102	glucose	CD36	MESH:D005947	12491(Tax:10090)	Chemical	Gene	bodies|compound|START_ENTITY bodies|nmod|mice mice|compound|END_ENTITY	Myocardial energy provision is preserved by increased utilization of glucose and ketone bodies in CD36 knockout mice .
26185606	0	glucose	55,62	CD36	0,4	glucose	CD36	MESH:D005947	948	Chemical	Gene	challenge|compound|START_ENTITY expression|nmod|challenge expression|compound|END_ENTITY	CD36 expression and lipid metabolism following an oral glucose challenge in South Asians .
16519917	0	glucose	93,100	CD4	13,16	glucose	CD4	MESH:D005947	920	Chemical	Gene	GLUT-1|compound|START_ENTITY mediated|nmod|GLUT-1 mediated|nsubjpass|Infection Infection|nmod|lymphocytes lymphocytes|nummod|END_ENTITY	Infection of CD4 + T lymphocytes by the human T_cell_leukemia_virus_type_1 is mediated by the glucose transporter GLUT-1 : evidence using antibodies specific to the receptor 's large extracellular domain .
20206208	0	glucose	34,41	CD4	116,119	glucose	CD4	MESH:D005947	920	Chemical	Gene	START_ENTITY|nmod|metabolism metabolism|nmod|T T|compound|END_ENTITY	Effects of hypoxia and/or lack of glucose on cellular energy metabolism and cytokine production in stimulated human CD4 + T lymphocytes .
24930970	0	glucose	4,11	CD4	59,62	glucose	CD4	MESH:D005947	920	Chemical	Gene	Glut1|compound|START_ENTITY essential|nsubj|Glut1 essential|nmod|activation activation|compound|END_ENTITY	The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function .
25501905	0	glucose	65,72	CD4	38,41	glucose	CD4	MESH:D005947	12504(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY regulating|dobj|uptake controls|advcl|regulating controls|dobj|survival survival|nmod|cells cells|compound|END_ENTITY	Notch controls the survival of memory CD4 + T cells by regulating glucose uptake .
26606199	0	glucose	14,21	CD4	36,39	glucose	CD4	MESH:D005947	920	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|nmod|END_ENTITY	Regulators of glucose metabolism in CD4 -LRB- + -RRB- and CD8 -LRB- + -RRB- T cells .
22293754	0	glucose	14,21	CD44	36,40	glucose	CD44	MESH:D005947	960	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|nmod|END_ENTITY	Modulation of glucose metabolism by CD44 contributes to antioxidant status and drug resistance in cancer cells .
23514176	0	glucose	29,36	CD8	17,20	glucose	CD8	MESH:D005947	925	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|compound|END_ENTITY	mTORC1 regulates CD8 + T-cell glucose metabolism and function independently of PI3K and PKB .
10438741	3	glucose	573,580	CLN3	498,502	glucose	ADA3	MESH:D005947	851756(Tax:4932)	Chemical	Gene	medium|compound|START_ENTITY observed|nmod|medium observed|nsubj|Deletion Deletion|nmod|delays delays|nummod|END_ENTITY	Deletion of CLN3 delays the increase in proliferation normally observed in response to glucose medium .
9721289	0	glucose	49,56	CLN3	30,34	glucose	CLN3	MESH:D005947	851191(Tax:4932)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Transcriptional regulation of CLN3 expression by glucose in Saccharomyces_cerevisiae .
19862665	0	glucose	31,38	COUP-TFII	0,9	glucose	COUP-TFII	MESH:D005947	7026	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	COUP-TFII is regulated by high glucose in endothelial cells .
16336954	0	glucose	73,80	CPI-17	17,23	glucose	CPI-17	MESH:D005947	68458(Tax:10090)	Chemical	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Up-regulation of CPI-17 phosphorylation in diabetic_vasculature and high glucose cultured vascular smooth muscle cells .
23756662	0	glucose	35,42	CPR	21,24	glucose	CPR	MESH:D005947	5447	Chemical	Gene	ratio|compound|START_ENTITY END_ENTITY|nmod|ratio	Correlation of serum CPR to plasma glucose ratio with various indices of insulin secretion and diseases duration in type 2 diabetes .
7556777	0	glucose	188,195	CRH	181,184	glucose	CRH	MESH:D005947	1392	Chemical	Gene	-RSB-|compound|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- Peripheral plasma corticotropin-releasing_hormone -LRB- CRH -RRB- in an aged patient with fasting hypoglycemia associated with an insufficient secretion of insulin : an implication of plasma CRH in glucose metabolism -RSB- .
3488736	0	glucose	17,24	CSF-1	0,5	glucose	CSF-1	MESH:D005947	12977(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY stimulates|dobj|uptake stimulates|nsubj|END_ENTITY	CSF-1 stimulates glucose uptake in murine bone marrow-derived macrophages .
18846327	0	glucose	5,12	CTGF	26,30	glucose	CTGF	MESH:D005947	1490	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|compound|END_ENTITY	High glucose promotes the CTGF expression in human mesangial cells via serum_and_glucocorticoid-induced_kinase_1 pathway .
25636275	0	glucose	16,23	CXCR-4	65,71	glucose	CXCR-4	MESH:D005947	60628(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Effect of high glucose on migration of BMSCs through inhibiting CXCR-4 . -RSB-
12745874	14	glucose	1297,1304	CYP2E1	1329,1335	glucose	CYP2E1	MESH:D005947	25086(Tax:10116)	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|compound|END_ENTITY	It is concluded that glucose can negatively regulate CYP2E1 expression and could at least partially explain the greater induction of hepatic CYP2E1 in rats fed low carbohydrate_ethanol-containing diets compared with high carbohydrate diets at the same ethanol level .
19210527	0	glucose	33,40	Calcineurin_inhibitor	0,21	glucose	Calcineurin inhibitor	MESH:D005947	23523	Chemical	Gene	metabolism|compound|START_ENTITY effects|nmod|metabolism effects|amod|END_ENTITY	Calcineurin_inhibitor effects on glucose metabolism and endothelial function following renal transplantation .
21803294	0	glucose	38,45	Cardiotrophin-1	0,15	glucose	Cardiotrophin-1	MESH:D005947	13019(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY regulator|nmod|metabolism regulator|nsubj|END_ENTITY	Cardiotrophin-1 is a key regulator of glucose and lipid metabolism .
14505347	0	glucose	34,41	Catalase	0,8	glucose	Catalase	MESH:D005947	847	Chemical	Gene	transduction|amod|START_ENTITY inhibits|dobj|transduction inhibits|nsubj|END_ENTITY	Catalase , but not MnSOD , inhibits glucose deprivation-activated ASK1-MEK-MAPK signal transduction pathway and prevents relocalization of Daxx : hydrogen_peroxide as a major second messenger of metabolic oxidative stress .
165074	1	glucose	49,56	Catalase	26,34	glucose	Catalase	MESH:D005947	847	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	V. Catalase inhibition of glucose oxidase reaction .
21506116	0	glucose	99,106	Caveolin-1	0,10	glucose	Caveolin-1	MESH:D005947	857	Chemical	Gene	MAPK|nmod|START_ENTITY proliferation|nmod|MAPK regulate|dobj|proliferation regulate|nsubj|b1 b1|compound|END_ENTITY	Caveolin-1 and integrin b1 regulate embryonic_stem cell proliferation via p38 MAPK and FAK in high glucose .
22105343	0	glucose	44,51	Caveolin-1	0,10	glucose	Caveolin-1	MESH:D005947	12389(Tax:10090)	Chemical	Gene	balance|nmod|START_ENTITY metabolism|dep|balance orchestrates|dep|metabolism orchestrates|amod|END_ENTITY	Caveolin-1 orchestrates the balance between glucose and lipid-dependent energy metabolism : implications for liver_regeneration .
27048255	0	glucose	31,38	Caveolin-1	0,10	glucose	Caveolin-1	MESH:D005947	857	Chemical	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	Caveolin-1 is involved in high glucose accelerated human glomerular mesangial cell senescence .
17005530	0	glucose	5,12	Cbfa1	41,46	glucose	Cbfa1	MESH:D005947	860	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	High glucose increases the expression of Cbfa1 and BMP-2 and enhances the calcification of vascular smooth muscle cells .
12842890	0	glucose	51,58	Cbl-b	13,18	glucose	Cbl-b	MESH:D005947	868	Chemical	Gene	transport|compound|START_ENTITY roles|nmod|transport roles|nmod|END_ENTITY	The roles of Cbl-b and c-Cbl in insulin-stimulated glucose transport .
15209533	0	glucose	44,51	Cd36	5,9	glucose	Cd36	MESH:D005947	29184(Tax:10116)	Chemical	Gene	play|nmod|START_ENTITY play|nsubj|gene gene|amod|END_ENTITY	Does Cd36 gene play a key role in disturbed glucose and fatty_acid metabolism in Prague hypertensive hypertriglyceridemic rats ?
24768698	0	glucose	5,12	Cdk5	23,27	glucose	Cdk5	MESH:D005947	140908(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|activity activity|amod|END_ENTITY	High glucose increases Cdk5 activity in podocytes via transforming_growth_factor-b1 signaling pathway .
12087089	0	glucose	34,41	ChREBP	0,6	glucose	ChREBP	MESH:D005947	171078(Tax:10116)	Chemical	Gene	stimulation|compound|START_ENTITY regulates|dobj|stimulation regulates|nsubj|END_ENTITY	ChREBP rather than USF2 regulates glucose stimulation of endogenous L-pyruvate_kinase expression in insulin-secreting cells .
12110366	0	glucose	77,84	ChREBP	49,55	glucose	ChREBP	MESH:D005947	51085	Chemical	Gene	metabolism|compound|START_ENTITY regulator|nmod|metabolism Carbohydrate_responsive_element-binding_protein|dep|regulator Carbohydrate_responsive_element-binding_protein|appos|END_ENTITY	Carbohydrate_responsive_element-binding_protein -LRB- ChREBP -RRB- : a key regulator of glucose metabolism and fat storage .
15733741	0	glucose	140,147	ChREBP	49,55	glucose	ChREBP	MESH:D005947	51085	Chemical	Gene	metabolism|compound|START_ENTITY regulators|nmod|metabolism Carbohydrate_responsive_element_binding_protein|dep|regulators Carbohydrate_responsive_element_binding_protein|appos|END_ENTITY	Carbohydrate_responsive_element_binding_protein -LRB- ChREBP -RRB- and sterol_regulatory_element_binding_protein-1c -LRB- SREBP-1c -RRB- : two key regulators of glucose metabolism and lipid synthesis in liver .
16614395	0	glucose	27,34	ChREBP	79,85	glucose	ChREBP	MESH:D005947	51085	Chemical	Gene	fatty_acids|compound|START_ENTITY regulation|nmod|fatty_acids regulation|dep|role role|nmod|END_ENTITY	Hepatic gene regulation by glucose and polyunsaturated fatty_acids : a role for ChREBP .
16890538	0	glucose	95,102	ChREBP	47,53	glucose	ChREBP	MESH:D005947	51085	Chemical	Gene	utilization|compound|START_ENTITY coupling|dep|utilization END_ENTITY|appos|coupling	Carbohydrate_response_element_binding_protein , ChREBP , a transcription factor coupling hepatic glucose utilization and lipid synthesis .
16891625	0	glucose	88,95	ChREBP	0,6	glucose	ChREBP	MESH:D005947	51085	Chemical	Gene	stimulated|nmod|START_ENTITY stimulated|nsubjpass|genes genes|amod|END_ENTITY	ChREBP binding to fatty_acid synthase and L-type pyruvate kinase genes is stimulated by glucose in pancreatic beta-cells .
17428181	0	glucose	39,46	ChREBP	0,6	glucose	ChREBP	MESH:D005947	58805(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY regulator|nmod|metabolism END_ENTITY|appos|regulator	ChREBP , a transcriptional regulator of glucose and lipid metabolism .
19799862	0	glucose	18,25	ChREBP	50,56	glucose	ChREBP	MESH:D005947	171078(Tax:10116)	Chemical	Gene	Replacing|dobj|START_ENTITY increases|csubj|Replacing increases|dobj|activity activity|compound|END_ENTITY	Replacing dietary glucose with fructose increases ChREBP activity and SREBP-1 protein in rat liver nucleus .
21036147	0	glucose	48,55	ChREBP	68,74	glucose	ChREBP	MESH:D005947	51085	Chemical	Gene	response|compound|START_ENTITY role|nmod|response role|nmod|END_ENTITY	The role of O-linked GlcNAc modification on the glucose response of ChREBP .
21282101	0	glucose	16,23	ChREBP	0,6	glucose	ChREBP	MESH:D005947	51085	Chemical	Gene	repression|compound|START_ENTITY mediates|dobj|repression mediates|nsubj|END_ENTITY	ChREBP mediates glucose repression of peroxisome_proliferator-activated_receptor_alpha expression in pancreatic beta-cells .
21835137	0	glucose	111,118	ChREBP	89,95	glucose	ChREBP	MESH:D005947	51085	Chemical	Gene	required|nmod|START_ENTITY required|nmod|activation activation|nmod|END_ENTITY	Glucose_6-phosphate , rather than xylulose 5-phosphate , is required for the activation of ChREBP in response to glucose in the liver .
22466288	0	glucose	60,67	ChREBP	8,14	glucose	ChREBP	MESH:D005947	51085	Chemical	Gene	metabolism|compound|START_ENTITY regulates|dobj|metabolism regulates|nsubj|isoform isoform|compound|END_ENTITY	A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism .
23604004	0	glucose	41,48	ChREBP	31,37	glucose	ChREBP	MESH:D005947	51085	Chemical	Gene	metabolism|compound|START_ENTITY progress|nmod|metabolism progress|nmod|role role|nmod|END_ENTITY	Recent progress on the role of ChREBP in glucose and lipid metabolism .
24449882	0	glucose	62,69	ChREBP	0,6	glucose	ChREBP	MESH:D005947	51085	Chemical	Gene	metabolism|compound|START_ENTITY enhances|dobj|metabolism enhances|nsubj|END_ENTITY	ChREBP , a glucose-responsive transcriptional factor , enhances glucose metabolism to support biosynthesis in human_cytomegalovirus-infected cells .
25827716	0	glucose	63,70	ChREBP	0,6	glucose	ChREBP	MESH:D005947	51085	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|lipogenesis lipogenesis|compound|END_ENTITY	ChREBP and LXRa mediate synergistically lipogenesis induced by glucose in porcine adipocytes .
27029511	0	glucose	99,106	ChREBP	66,72	glucose	ChREBP	MESH:D005947	58805(Tax:10090)	Chemical	Gene	promote|nmod|START_ENTITY promote|dobj|expression expression|amod|END_ENTITY	Identification of HNF-4a as a key transcription factor to promote ChREBP expression in response to glucose .
1405602	0	glucose	33,40	Cholecystokinin	0,15	glucose	Cholecystokinin	MESH:D005947	885	Chemical	Gene	effects|nmod:poss|START_ENTITY mediate|dobj|effects mediate|nsubj|END_ENTITY	Cholecystokinin does not mediate glucose 's cytoprotective effects .
2891102	0	glucose	133,140	Cholecystokinin	0,15	glucose	Cholecystokinin	MESH:D005947	25298(Tax:10116)	Chemical	Gene	interaction|nmod|START_ENTITY glucagon|dep|interaction regulates|dobj|glucagon regulates|nsubj|END_ENTITY	Cholecystokinin -LRB- CCK8 -RRB- regulates glucagon , insulin , and somatostatin secretion from isolated rat pancreatic islets : interaction with glucose .
23056614	0	glucose	25,32	Chrebp	87,93	glucose	Chrebp	MESH:D005947	51085	Chemical	Gene	utilization|compound|START_ENTITY utilization|nmod|regulation regulation|nmod|O-glycosylation O-glycosylation|compound|END_ENTITY	Hepatic FoxO1 integrates glucose utilization and lipid synthesis through regulation of Chrebp O-glycosylation .
19136654	0	glucose	46,53	Ciliary_neurotrophic_factor	0,27	glucose	Ciliary neurotrophic factor	MESH:D005947	12803(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY stimulates|dobj|uptake stimulates|nsubj|END_ENTITY	Ciliary_neurotrophic_factor stimulates muscle glucose uptake by a PI3-kinase-dependent pathway that is impaired with obesity .
15345671	0	glucose	46,53	Connective_tissue_growth_factor	0,31	glucose	Connective tissue growth factor	MESH:D005947	1490	Chemical	Gene	effects|compound|START_ENTITY mediates|dobj|effects mediates|nsubj|END_ENTITY	Connective_tissue_growth_factor mediates high glucose effects on matrix degradation through tissue inhibitor of matrix metalloproteinase type 1 : implications for diabetic_nephropathy .
15980944	0	glucose	157,164	Connective_tissue_growth_factor	0,31	glucose	Connective tissue growth factor	MESH:D005947	14219(Tax:10090)	Chemical	Gene	produced|nmod|START_ENTITY factor-beta|acl|produced transforming|dobj|factor-beta effects|acl|transforming mediates|dobj|effects mediates|nsubj|END_ENTITY	Connective_tissue_growth_factor mediates the profibrotic effects of transforming growth factor-beta produced by tubular epithelial cells in response to high glucose .
23950936	0	glucose	77,84	Connective_tissue_growth_factor	0,31	glucose	Connective tissue growth factor	MESH:D005947	14219(Tax:10090)	Chemical	Gene	modulates|nmod|START_ENTITY modulates|nsubj|expression expression|amod|END_ENTITY	Connective_tissue_growth_factor -LRB- CTGF -RRB- expression modulates response to high glucose .
24533694	0	glucose	91,98	Copeptin	0,8	glucose	Copeptin	MESH:D005947	551	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	Copeptin , a surrogate marker for arginine_vasopressin secretion , is associated with higher glucose and insulin concentrations but not higher blood pressure in obese men .
21670153	0	glucose	16,23	CrbpI	0,5	glucose	CrbpI	MESH:D005947	19659(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY modulates|dobj|homeostasis modulates|nsubj|END_ENTITY	CrbpI modulates glucose homeostasis and pancreas 9-cis-retinoic_acid concentrations .
25338812	0	glucose	24,31	Cyp8b1	8,14	glucose	Cyp8b1	MESH:D005947	13124(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY improves|dobj|homeostasis improves|nsubj|Loss Loss|nmod|END_ENTITY	Loss of Cyp8b1 improves glucose homeostasis by increasing GLP-1 .
24415752	6	glucose	797,804	DBC1	782,786	glucose	DBC1	MESH:D005947	56710(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY regulates|dobj|metabolism regulates|nsubj|END_ENTITY	In this work , we provide evidence that DBC1 regulates glucose metabolism and the expression of PEPCK .
25918236	0	glucose	26,33	DLK1	0,4	glucose	DLK1	MESH:D005947	13388(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY regulates|dobj|metabolism regulates|nsubj|END_ENTITY	DLK1 regulates whole body glucose metabolism : A negative feedback regulation of the osteocalcin-insulin_loop .
25918236	0	glucose	26,33	DLK1	0,4	glucose	DLK1	MESH:D005947	13388(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY regulates|dobj|metabolism regulates|nsubj|END_ENTITY	DLK1 regulates whole body glucose metabolism : A negative feedback regulation of the osteocalcin-insulin_loop .
17482289	0	glucose	26,33	DPP-4	0,5	glucose	DPP-4	MESH:D005947	13482(Tax:10090)	Chemical	Gene	tolerance|compound|START_ENTITY improves|dobj|tolerance improves|nsubj|inhibition inhibition|compound|END_ENTITY	DPP-4 inhibition improves glucose tolerance and increases insulin and GLP-1 responses to gastric glucose in association with normalized islet topography in mice with beta-cell-specific overexpression of human islet amyloid polypeptide .
18805504	0	glucose	40,47	Dynamin-related_protein_1	0,25	glucose	Dynamin-related protein 1	MESH:D005947	10059	Chemical	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	Dynamin-related_protein_1 mediates high glucose induced pancreatic beta cell apoptosis .
20403881	0	glucose	62,69	E-cadherin	39,49	glucose	E-cadherin	MESH:D005947	442858(Tax:9615)	Chemical	Gene	transporter|amod|START_ENTITY transporter|amod|END_ENTITY	Immunohistochemical detection of CD34 , E-cadherin , claudin-1 , glucose transporter 1 , laminin , and protein gene product 9.5 in 28 canine and 8 feline meningiomas .
18776139	0	glucose	40,47	ENPP1	12,17	glucose	ENPP1	MESH:D005947	5167	Chemical	Gene	polymorphism|nmod|START_ENTITY polymorphism|compound|END_ENTITY	Role of the ENPP1 K121Q polymorphism in glucose homeostasis .
3509274	0	glucose	11,18	ERG	92,95	glucose	ERG	MESH:D005947	100347277(Tax:9986)	Chemical	Gene	Effects|nmod|START_ENTITY added|nsubj|Effects added|nmod|END_ENTITY	Effects of glucose and fructose added to the intraocular irrigating solutions on the rabbit ERG in vitro .
11701441	0	glucose	22,29	ERK1/2	47,53	glucose	ERK1/2	MESH:D005947	50689;116590	Chemical	Gene	START_ENTITY|nmod|mediator mediator|nmod|END_ENTITY	Evidence against high glucose as a mediator of ERK1/2 or p38 MAPK phosphorylation in rat skeletal muscle .
15921682	0	glucose	61,68	ERK1/2	0,6	glucose	ERK1/2	MESH:D005947	50689;116590	Chemical	Gene	uptake|compound|START_ENTITY inhibits|dobj|uptake inhibits|nsubj|activation activation|nummod|END_ENTITY	ERK1/2 activation by angiotensin_II inhibits insulin-induced glucose uptake in vascular smooth muscle cells .
16061020	0	glucose	6,13	ERK1/2	68,74	glucose	ERK1/2	MESH:D005947	26417;26413	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- High glucose regulates the production of MMP-9 in podocyte through ERK1/2 signal pathway -RSB- .
19074139	0	glucose	105,112	ERK1/2	84,90	glucose	ERK1/2	MESH:D005947	26417;26413	Chemical	Gene	required|nmod|START_ENTITY required|nmod|potentiation potentiation|nmod|activation activation|compound|END_ENTITY	beta-Arrestin_1 is required for PAC1 receptor-mediated potentiation of long-lasting ERK1/2 activation by glucose in pancreatic beta-cells .
19672022	0	glucose	5,12	ERK1/2	84,90	glucose	ERK1/2	MESH:D005947	5595;5594	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	High glucose induces transactivation of the alpha2-HS_glycoprotein gene through the ERK1/2 signaling pathway .
20225236	0	glucose	14,21	ERK1/2	101,107	glucose	ERK1/2	MESH:D005947	5595;5594	Chemical	Gene	upregulate|nsubj|START_ENTITY upregulate|nmod|phagocytes phagocytes|nmod|pathways pathways|compound|END_ENTITY	IL-6 and high glucose synergistically upregulate MMP-1 expression by U937 mononuclear phagocytes via ERK1/2 and JNK pathways and c-Jun .
21135229	0	glucose	22,29	ERK1/2	44,50	glucose	ERK1/2	MESH:D005947	5595;5594	Chemical	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Calcineurin increases glucose activation of ERK1/2 by reversing negative feedback .
21135229	5	glucose	630,637	ERK1/2	652,658	glucose	ERK1/2	MESH:D005947	5595;5594	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|cascade cascade|compound|END_ENTITY	Here , we show that , in b cells , glucose activates the ERK1/2 cascade primarily through B-Raf .
23109389	0	glucose	54,61	ERK1/2	102,108	glucose	ERK1/2	MESH:D005947	5595;5594	Chemical	Gene	START_ENTITY|dep|phosphorylation phosphorylation|nmod|END_ENTITY	Magnetic labeling of pancreatic b-cells modulates the glucose - _ and_insulin-induced phosphorylation of ERK1/2 and AKT .
23344729	0	glucose	26,33	ERK1/2	119,125	glucose	ERK1/2	MESH:D005947	26417;26413	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|role role|nmod|activation activation|nummod|END_ENTITY	The permissive effects of glucose on receptor-operated potentiation of insulin secretion from mouse islets : a role for ERK1/2 activation and cytoskeletal remodelling .
23394397	0	glucose	115,122	ERK1/2	131,137	glucose	ERK1/2	MESH:D005947	26417;26413	Chemical	Gene	START_ENTITY|nmod|pathway pathway|compound|END_ENTITY	Gremlin induces cell proliferation and extra cellular matrix accumulation in mouse mesangial cells exposed to high glucose via the ERK1/2 pathway .
24885625	0	glucose	5,12	ERK1/2	70,76	glucose	ERK1/2	MESH:D005947	26417;26413	Chemical	Gene	increases|nsubj|START_ENTITY increases|nmod|modulation modulation|nmod|-2 -2|compound|END_ENTITY	High glucose increases LPS-induced DC apoptosis through modulation of ERK1/2 , AKT and Bax/Bcl -2 .
10619403	0	glucose	18,25	ERK2	72,76	glucose	ERK2	MESH:D005947	26413(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY stimulates|dobj|uptake stimulates|nmod|activation activation|nmod|END_ENTITY	Leptin stimulates glucose uptake in C2C12 muscle cells by activation of ERK2 .
9746345	0	glucose	80,87	ERp57	29,34	glucose	ERp57	MESH:D005947	2923	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|association association|nmod|END_ENTITY	The transient association of ERp57 with N-glycosylated proteins is regulated by glucose trimming .
11516624	0	glucose	23,30	Endothelin-1	0,12	glucose	Endothelin-1	MESH:D005947	1906	Chemical	Gene	accumulation|compound|START_ENTITY increases|dobj|accumulation increases|nsubj|END_ENTITY	Endothelin-1 increases glucose transporter glut1 mRNA accumulation in 3T3-L1 adipocytes by a mitogen-activated protein kinase-dependent pathway .
12172700	0	glucose	88,95	Endothelin-1	0,12	glucose	Endothelin-1	MESH:D005947	24323(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY instability|acl|induced reduce|dobj|instability reduce|nsubj|antagonists antagonists|amod|END_ENTITY	Endothelin-1 receptor antagonists reduce cardiac electrical instability induced by high glucose in rats .
15086527	0	glucose	67,74	Endothelin-1	0,12	glucose	Endothelin-1	MESH:D005947	1906	Chemical	Gene	transporter|compound|START_ENTITY translocation|nmod|transporter stimulates|dobj|translocation stimulates|nsubj|END_ENTITY	Endothelin-1 stimulates the translocation and upregulation of both glucose transporter and hexokinase in astrocytes : relationship with gap junctional communication .
16240321	0	glucose	21,28	Endothelin-1	0,12	glucose	Endothelin-1	MESH:D005947	1906	Chemical	Gene	trafficking|compound|START_ENTITY impairs|dobj|trafficking impairs|nsubj|END_ENTITY	Endothelin-1 impairs glucose transporter trafficking via a membrane-based mechanism .
20728421	0	glucose	25,32	Endothelin-1	0,12	glucose	Endothelin-1	MESH:D005947	1906	Chemical	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Endothelin-1 response to glucose and insulin among African Americans .
21677282	0	glucose	21,28	Endothelin-1	0,12	glucose	Endothelin-1	MESH:D005947	1906	Chemical	Gene	uptake|compound|START_ENTITY reduces|dobj|uptake reduces|nsubj|END_ENTITY	Endothelin-1 reduces glucose uptake in human skeletal muscle in vivo and in vitro .
7476292	0	glucose	23,30	Endothelin-1	0,12	glucose	Endothelin-1	MESH:D005947	24323(Tax:10116)	Chemical	Gene	decreases|dobj|START_ENTITY decreases|nsubj|END_ENTITY	Endothelin-1 decreases glucose , inhibits glucagon , and stimulates insulin release in the rat .
8048938	0	glucose	41,48	Endothelin-1	0,12	glucose	Endothelin-1	MESH:D005947	24323(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY inhibits|dobj|uptake inhibits|nsubj|END_ENTITY	Endothelin-1 inhibits insulin-stimulated glucose uptake in isolated rat adipocytes .
8833189	0	glucose	23,30	Endothelin-1	0,12	glucose	Endothelin-1	MESH:D005947	1906	Chemical	Gene	utilization|compound|START_ENTITY regulates|dobj|utilization regulates|nsubj|END_ENTITY	Endothelin-1 regulates glucose utilization in cultured astrocytes by controlling intercellular communication through gap junctions .
9080369	0	glucose	71,78	Endothelin-1	0,12	glucose	Endothelin-1	MESH:D005947	1906	Chemical	Gene	absorption|compound|START_ENTITY secretion|dep|absorption secretion|amod|END_ENTITY	Endothelin-1 potently stimulates chloride secretion and inhibits Na -LRB- + -RRB- - glucose absorption in human intestine in vitro .
10491655	0	glucose	34,41	Epidermal_growth_factor	0,23	glucose	Epidermal growth factor	MESH:D005947	1950	Chemical	Gene	metabolism|compound|START_ENTITY regulates|dobj|metabolism regulates|nsubj|END_ENTITY	Epidermal_growth_factor regulates glucose metabolism through lactate_dehydrogenase_A messenger ribonucleic acid expression in cultured porcine Sertoli cells .
1608538	0	glucose	32,39	Epidermal_growth_factor	0,23	glucose	Epidermal growth factor	MESH:D005947	1950	Chemical	Gene	transport|compound|START_ENTITY induces|dobj|transport induces|nsubj|END_ENTITY	Epidermal_growth_factor induces glucose transport in primary cell cultures derived from human astrocytic_glioma biopsies .
7999123	0	glucose	73,80	Epidermal_growth_factor	0,23	glucose	Epidermal growth factor	MESH:D005947	100763146	Chemical	Gene	transporter|compound|START_ENTITY translocation|nmod|transporter triggers|dobj|translocation triggers|nsubj|END_ENTITY	Epidermal_growth_factor triggers the translocation of insulin-responsive glucose transporter -LRB- GLUT4 -RRB- .
8484015	0	glucose	68,75	Epidermal_growth_factor	0,23	glucose	Epidermal growth factor	MESH:D005947	25313(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY interferes|nmod|production interferes|nsubj|END_ENTITY	Epidermal_growth_factor interferes with the effect of adrenaline on glucose production and on hepatic_lipase secretion in rat hepatocytes .
8866569	0	glucose	32,39	Epidermal_growth_factor	0,23	glucose	Epidermal growth factor	MESH:D005947	1950	Chemical	Gene	storage|compound|START_ENTITY induces|dobj|storage induces|nsubj|END_ENTITY	Epidermal_growth_factor induces glucose storage in transgenic 3T3-L1 adipocytes overexpressing epidermal_growth_factor receptors .
9878331	0	glucose	51,58	Epidermal_growth_factor	0,23	glucose	Epidermal growth factor	MESH:D005947	25313(Tax:10116)	Chemical	Gene	absorption|compound|START_ENTITY recovery|nmod|absorption stimulates|dobj|recovery stimulates|nsubj|END_ENTITY	Epidermal_growth_factor stimulates the recovery of glucose absorption after small bowel transplantation .
23040071	0	glucose	74,81	Erk1/2	18,24	glucose	Erk1/2	MESH:D005947	50689;116590	Chemical	Gene	production|compound|START_ENTITY inhibit|dobj|production signaling|xcomp|inhibit END_ENTITY|acl|signaling	Insulin activates Erk1/2 signaling in the dorsal vagal complex to inhibit glucose production .
20061512	0	glucose	48,55	Erythropoietin	0,14	glucose	Erythropoietin	MESH:D005947	13856(Tax:10090)	Chemical	Gene	levels|compound|START_ENTITY leads|nmod|levels leads|nsubj|treatment treatment|compound|END_ENTITY	Erythropoietin treatment leads to reduced blood glucose levels and body mass : insights from murine models .
20685070	0	glucose	100,107	Erythropoietin	0,14	glucose	Erythropoietin	MESH:D005947	2056	Chemical	Gene	level|compound|START_ENTITY generation|nmod|level prevents|dobj|generation prevents|nsubj|END_ENTITY	Erythropoietin prevents reactive oxygen species generation and renal tubular cell apoptosis at high glucose level .
26126591	0	glucose	24,31	Erythropoietin	0,14	glucose	Erythropoietin	MESH:D005947	24335(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY improves|dobj|metabolism improves|nsubj|END_ENTITY	Erythropoietin improves glucose metabolism and pancreatic b-cell damage in experimental diabetic rats .
9534011	0	glucose	31,38	Erythropoietin	0,14	glucose	Erythropoietin	MESH:D005947	2056	Chemical	Gene	control|compound|START_ENTITY deteriorate|dobj|control deteriorate|nsubj|END_ENTITY	Erythropoietin can deteriorate glucose control in uraemic non-insulin-dependent diabetic patients .
11095645	0	glucose	91,98	Extracellular_signal-regulated_kinase	0,37	glucose	Extracellular signal-regulated kinase	MESH:D005947	24338(Tax:10116)	Chemical	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Extracellular_signal-regulated_kinase mediates stimulation of TGF-beta1 and matrix by high glucose in mesangial cells .
23530005	0	glucose	95,102	Extracellular_signal-regulated_kinase	0,37	glucose	Extracellular signal-regulated kinase	MESH:D005947	26413(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY mediates|dobj|uptake mediates|nsubj|END_ENTITY	Extracellular_signal-regulated_kinase in the ventromedial hypothalamus mediates leptin-induced glucose uptake in red-type skeletal muscle .
23559715	0	glucose	43,50	F-18	25,29	glucose	F-18	MESH:D005947	10046	Chemical	Gene	uptake|compound|START_ENTITY uptake|compound|END_ENTITY	New axillary lymph nodal F-18 fluoro-deoxy glucose uptake in an interim positron emission tomography scan - not always a sign of disease progression .
26983463	0	glucose	68,75	FBW7	0,4	glucose	FBW7	MESH:D005947	55294	Chemical	Gene	metabolism|compound|START_ENTITY regulates|dobj|metabolism regulates|nsubj|END_ENTITY	FBW7 -LRB- F-box_and_WD_repeat_domain-containing_7 -RRB- negatively regulates glucose metabolism by targeting the c-Myc/TXNIP -LRB- thioredoxin_binding_protein -RRB- axis in pancreatic_cancer .
18840786	1	glucose	245,252	FGF21	187,192	glucose	FGF21	MESH:D005947	56636(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY regulator|nmod|metabolism emerged|nmod|regulator emerged|nsubj|Fibroblast_growth_factor_21 Fibroblast_growth_factor_21|appos|END_ENTITY	OBJECTIVE : Fibroblast_growth_factor_21 -LRB- FGF21 -RRB- has emerged as an important metabolic regulator of glucose and lipid metabolism .
21309058	0	glucose	27,34	FGF21	18,23	glucose	FGF21	MESH:D005947	26291	Chemical	Gene	uptake|compound|START_ENTITY END_ENTITY|nmod|uptake	Direct effects of FGF21 on glucose uptake in human skeletal muscle : implications for type 2 diabetes and obesity .
21712364	8	glucose	1467,1474	FGF21	1367,1372	glucose	FGF21	MESH:D005947	56636(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY necessary|nmod|metabolism indicating|ccomp|necessary revealed|xcomp|indicating revealed|nmod|END_ENTITY	However , studies using mice with liver-specific ablation of PGC-1a revealed the same regulation of gluconeogenic gene expression by FGF21 as seen in wild-type mice , indicating that PGC-1a is not necessary for the effect of FGF21 on glucose metabolism .
21713513	0	glucose	42,49	FGF21	87,92	glucose	FGF21	MESH:D005947	26291	Chemical	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Large-scale expression , purification , and glucose uptake activity of recombinant human FGF21 in Escherichia_coli .
22539584	0	glucose	52,59	FGF21	24,29	glucose	FGF21	MESH:D005947	26291	Chemical	Gene	challenge|compound|START_ENTITY change|nmod|challenge change|nmod|levels levels|compound|END_ENTITY	Dynamic change of serum FGF21 levels in response to glucose challenge in human .
23305840	0	glucose	25,32	FGF21	0,5	glucose	FGF21	MESH:D005947	170580(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY suppresses|dobj|production suppresses|nsubj|END_ENTITY	FGF21 suppresses hepatic glucose production through the activation of atypical protein kinase C / .
23663741	0	glucose	55,62	FGF21	46,51	glucose	FGF21	MESH:D005947	56636(Tax:10090)	Chemical	Gene	homeostasis_and_insulin_sensitivity|compound|START_ENTITY mediates|nmod|homeostasis_and_insulin_sensitivity mediates|dobj|effects effects|nmod|END_ENTITY	Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis_and_insulin_sensitivity in mice .
26099854	0	glucose	26,33	FGF21	0,5	glucose	FGF21	MESH:D005947	56636(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY required|nmod|homeostasis required|nsubjpass|END_ENTITY	FGF21 is not required for glucose homeostasis , ketosis or tumour suppression associated with ketogenic diets in mice .
26274346	0	glucose	52,59	FGF21	0,5	glucose	FGF21	MESH:D005947	26291	Chemical	Gene	control|compound|START_ENTITY effect|nmod|control response|dep|effect response|nummod|END_ENTITY	FGF21 response to critical_illness : effect of blood glucose control and relation with cellular stress and survival .
26607153	0	glucose	28,35	FGF21	19,24	glucose	FGF21	MESH:D005947	56636(Tax:10090)	Chemical	Gene	metabolisms|compound|START_ENTITY END_ENTITY|nmod|metabolisms	Insulin sensitizes FGF21 in glucose and lipid metabolisms via activating common AKT pathway .
23826391	0	glucose	45,52	FGT-1	0,5	glucose	FGT-1	MESH:D005947	173525(Tax:6239)	Chemical	Gene	transporter|compound|START_ENTITY transporter|nsubj|END_ENTITY	FGT-1 is a mammalian GLUT2-like facilitative glucose transporter in Caenorhabditis_elegans whose malfunction induces fat accumulation in intestinal cells .
24024580	0	glucose	19,26	FGT-1	0,5	glucose	FGT-1	MESH:D005947	173525(Tax:6239)	Chemical	Gene	transporter|compound|START_ENTITY transporter|nsubj|END_ENTITY	FGT-1 is the major glucose transporter in C. _ elegans and is central to aging pathways .
22809027	0	glucose	25,32	FOXO1	90,95	glucose	FOXO1	MESH:D005947	84482(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|acl|repressing repressing|dobj|END_ENTITY	Zhenqing recipe improves glucose metabolism and insulin sensitivity by repressing hepatic FOXO1 in type 2 diabetic rats .
25223702	0	glucose	30,37	FOXO1	78,83	glucose	FOXO1	MESH:D005947	56458(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY improves|dobj|metabolism improves|advcl|modulating modulating|dobj|activity activity|compound|END_ENTITY	Liver Med23 ablation improves glucose and lipid metabolism through modulating FOXO1 activity .
26902117	0	glucose	99,106	FOXO1	18,23	glucose	FOXO1	MESH:D005947	56458(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY transition|acl|induced ameliorates|dobj|transition ameliorates|nsubj|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of FOXO1 ameliorates the podocyte epithelial-mesenchymal transition induced by high glucose in vitro and in vivo .
26118101	0	glucose	32,39	Farnesoid_X_receptor	1,21	glucose	Farnesoid X receptor	MESH:D005947	9971	Chemical	Gene	metabolisms|compound|START_ENTITY -RSB-|nsubj|metabolisms regulates|xcomp|-RSB- regulates|nsubj|END_ENTITY	-LSB- Farnesoid_X_receptor regulates glucose and lipid metabolisms -RSB- .
21501347	0	glucose	40,47	Fatty_acid-binding_protein_3	0,28	glucose	Fatty acid-binding protein 3	MESH:D005947	14077(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY stimulates|dobj|uptake stimulates|nsubj|END_ENTITY	Fatty_acid-binding_protein_3 stimulates glucose uptake by facilitating AS160 phosphorylation in mouse muscle cells .
23831019	0	glucose	54,61	Fgf21	10,15	glucose	Fgf21	MESH:D005947	56636(Tax:10090)	Chemical	Gene	utilization|compound|START_ENTITY normalizes|dobj|utilization normalizes|nsubj|END_ENTITY	Pegylated Fgf21 rapidly normalizes insulin-stimulated glucose utilization in diet-induced insulin resistant mice .
25170746	0	glucose	50,57	Fibroblast_growth_factor_21	0,27	glucose	Fibroblast growth factor 21	MESH:D005947	26291	Chemical	Gene	protects|nmod|START_ENTITY protects|nsubj|END_ENTITY	Fibroblast_growth_factor_21 protects against high glucose induced cellular damage_and_dysfunction of endothelial_nitric-oxide_synthase in endothelial cells .
18280254	0	glucose	76,83	FoxO1	19,24	glucose	FoxO1	MESH:D005947	2308	Chemical	Gene	gene|compound|START_ENTITY increases|nmod|gene increases|nsubj|O-glycosylation O-glycosylation|nmod|END_ENTITY	O-glycosylation of FoxO1 increases its transcriptional activity towards the glucose 6-phosphatase gene .
20038793	0	glucose	42,49	FoxO1	0,5	glucose	FoxO1	MESH:D005947	56458(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY regulates|dobj|homeostasis regulates|nsubj|expression expression|amod|END_ENTITY	FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice .
22011624	0	glucose	14,21	FoxO1	78,83	glucose	FoxO1	MESH:D005947	56458(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY Regulation|nmod|metabolism forkhead|nsubj|Regulation forkhead|dobj|factor factor|appos|END_ENTITY	Regulation of glucose metabolism via hepatic forkhead transcription factor 1 -LRB- FoxO1 -RRB- by Morinda citrifolia -LRB- noni -RRB- in high-fat diet-induced obese mice .
22055502	0	glucose	20,27	FoxO1	62,67	glucose	FoxO1	MESH:D005947	56458(Tax:10090)	Chemical	Gene	Dissociation|nmod|START_ENTITY Dissociation|nmod|END_ENTITY	Dissociation of the glucose and lipid regulatory functions of FoxO1 by targeted knockin of acetylation-defective alleles in mice .
22298775	0	glucose	69,76	FoxO1	0,5	glucose	FoxO1	MESH:D005947	2308	Chemical	Gene	homeostasis|compound|START_ENTITY control|dobj|homeostasis cooperates|xcomp|control cooperates|nsubj|protein protein|amod|END_ENTITY	FoxO1 protein cooperates with ATF4 protein in osteoblasts to control glucose homeostasis .
22532369	4	glucose	866,873	FoxO1	849,854	glucose	FoxO1	MESH:D005947	56458(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	In this study , we attempted to directly test the effect of arginine methylation of FoxO1 on hepatic glucose metabolism .
23056614	0	glucose	25,32	FoxO1	8,13	glucose	FoxO1	MESH:D005947	2308	Chemical	Gene	utilization|compound|START_ENTITY integrates|dobj|utilization integrates|nsubj|END_ENTITY	Hepatic FoxO1 integrates glucose utilization and lipid synthesis through regulation of Chrebp O-glycosylation .
24329853	0	glucose	31,38	FoxO1	125,130	glucose	FoxO1	MESH:D005947	2308	Chemical	Gene	homeostasis|compound|START_ENTITY dysregulates|dobj|homeostasis dysregulates|nmod|mechanism mechanism|nmod|induction induction|nmod|PGC1a PGC1a|nmod|END_ENTITY	Hepatitis_C virus dysregulates glucose homeostasis by a dual mechanism involving induction of PGC1a and dephosphorylation of FoxO1 .
24914090	0	glucose	75,82	FoxO1	14,19	glucose	FoxO1	MESH:D005947	84482(Tax:10116)	Chemical	Gene	conditions|compound|START_ENTITY mesangial|nmod|conditions mesangial|nsubj|effect effect|nmod|END_ENTITY	The effect of FoxO1 on the proliferation of rat mesangial cells under high glucose conditions .
24260294	0	glucose	5,12	FoxO3a	112,118	glucose	FoxO3a	MESH:D005947	294515(Tax:10116)	Chemical	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	High glucose induced oxidative stress and apoptosis in cardiac microvascular endothelial cells are regulated by FoxO3a .
23324123	0	glucose	9,16	FoxO6	0,5	glucose	FoxO6	MESH:D005947	329934(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	FoxO6 in glucose metabolism -LRB- FoxO6 -RRB- .
23324123	0	glucose	9,16	FoxO6	29,34	glucose	FoxO6	MESH:D005947	329934(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|appos|END_ENTITY	FoxO6 in glucose metabolism -LRB- FoxO6 -RRB- .
20655898	0	glucose	57,64	Foxo1	21,26	glucose	Foxo1	MESH:D005947	56458(Tax:10090)	Chemical	Gene	AS1708727|nmod|START_ENTITY AS1708727|amod|END_ENTITY	Effects of the novel Foxo1 inhibitor AS1708727 on plasma glucose and triglyceride levels in diabetic db/db mice .
19204003	0	glucose	77,84	Fxr	99,102	glucose	Fxr	MESH:D005947	20186(Tax:10090)	Chemical	Gene	absorption|compound|START_ENTITY absorption|nmod|END_ENTITY	An increased flux through the glucose_6-phosphate pool in enterocytes delays glucose absorption in Fxr - / - mice .
12169448	0	glucose	85,92	G-6-Pase	62,70	glucose	G-6-Pase	MESH:D005947	25634(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY production|amod|END_ENTITY	Diets enriched in sucrose or fat increase gluconeogenesis and G-6-Pase but not basal glucose production in rats .
8786155	0	glucose	10,17	G6PD	45,49	glucose	G6PD	MESH:D005947	2539	Chemical	Gene	dehydrogenase|compound|START_ENTITY dehydrogenase|appos|END_ENTITY	Leukocyte glucose 6 phosphate dehydrogenase -LRB- G6PD -RRB- as prognostic indicator in children with acute_lymphocytic_leukemia .
21907636	0	glucose	109,116	GAD65	17,22	glucose	GAD65	MESH:D005947	24380(Tax:10116)	Chemical	Gene	stress|nmod|START_ENTITY stress|nsubj|Up-expression Up-expression|nmod|END_ENTITY	Up-expression of GAD65 in the amygdala of the rat model of chronic immobilization stress with elevated blood glucose .
12716756	0	glucose	35,42	GAPDH	61,66	glucose	GAPDH	MESH:D005947	24383(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Maternal_diabetes in vivo and high glucose in vitro diminish GAPDH activity in rat embryos .
19472021	12	glucose	1443,1450	GB1	1458,1461	glucose	GB1	MESH:D005947	81657(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|groups groups|compound|END_ENTITY	Fasting glucose in the GB1 and GB2 groups was much lower than the CO1 and CO2 groups .
6113725	0	glucose	110,117	GGT	17,20	glucose	GGT	MESH:D005947	2678	Chemical	Gene	load|compound|START_ENTITY glucose|nmod|load influence|nmod|glucose influence|nmod|END_ENTITY	The influence of GGT , COHb % and body weight on the 2-h glucose and insulin response after a standardized oral glucose load .
6113725	0	glucose	55,62	GGT	17,20	glucose	GGT	MESH:D005947	2678	Chemical	Gene	influence|nmod|START_ENTITY influence|nmod|END_ENTITY	The influence of GGT , COHb % and body weight on the 2-h glucose and insulin response after a standardized oral glucose load .
10770216	0	glucose	120,127	GH	49,51	glucose	GH	MESH:D005947	2688	Chemical	Gene	lipid|dep|START_ENTITY effects|nmod|lipid Insulin-like_growth_factor_I|dep|effects Insulin-like_growth_factor_I|appos|END_ENTITY	Insulin-like_growth_factor_I and growth_hormone -LRB- GH -RRB- treatment in GH-deficient humans : differential effects on protein , glucose , lipid , and calcium metabolism .
11443176	6	glucose	1502,1509	GH	1461,1463	glucose	GH	MESH:D005947	2688	Chemical	Gene	levels|compound|START_ENTITY induced|nmod|levels induced|nsubj|continuation continuation|nmod|END_ENTITY	Finally , continuation of GH induced moderate elevations in plasma glucose levels without significant changes in total_glucose_turnover or oxidation .
1313957	8	glucose	1540,1547	GH	1423,1425	glucose	GH	MESH:D005947	2688	Chemical	Gene	levels|compound|START_ENTITY similar|nsubj|levels maintain|xcomp|similar cause|acl:relcl|maintain cause|advmod|due due|nmod|END_ENTITY	We conclude the 1 -RRB- increased insulin clearance is responsible for the dawn phenomenon in healthy and diabetic adolescents and 2 -RRB- insulin resistance due to GH is an unlikely cause for the dawn phenomenon because diabetic subjects , despite higher GH levels , maintain plasma glucose levels similar to control subjects without requiring higher plasma free insulin concentrations .
2104760	0	glucose	11,18	GH	56,58	glucose	GH	MESH:D005947	2688	Chemical	Gene	Failure|nmod|START_ENTITY infusion|nsubj|Failure infusion|xcomp|suppress suppress|dobj|response response|compound|END_ENTITY	Failure of glucose infusion to suppress the exaggerated GH response to GHRH in patients with anorexia_nervosa .
22565153	0	glucose	93,100	GH	51,53	glucose	GH	MESH:D005947	2688	Chemical	Gene	metabolism|compound|START_ENTITY levels|nmod|metabolism Comparison|nmod|levels Comparison|appos|END_ENTITY	Comparison of two dose regimens of growth_hormone -LRB- GH -RRB- with different target IGF-1 levels on glucose metabolism , lipid profile , cardiovascular function and anthropometric parameters in gh-deficient adults .
2273206	0	glucose	15,22	GH	78,80	glucose	GH	MESH:D005947	2688	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|appos|END_ENTITY	Interaction of glucose and pyridostigmine on the secretion of growth_hormone -LRB- GH -RRB- induced by GH-releasing_hormone -LRB- GHRH -RRB- .
24498035	0	glucose	53,60	GH	27,29	glucose	GH	MESH:D005947	2688	Chemical	Gene	metabolism|compound|START_ENTITY withdrawal|nmod|metabolism withdrawal|amod|growth_hormone growth_hormone|dep|END_ENTITY	Effects of growth_hormone -LRB- GH -RRB- therapy withdrawal on glucose metabolism in not confirmed GH_deficient adolescents at final height .
3919046	0	glucose	14,21	GH	41,43	glucose	GH	MESH:D005947	2688	Chemical	Gene	START_ENTITY|nmod|growth_hormone growth_hormone|appos|END_ENTITY	The effect of glucose on growth_hormone -LRB- GH -RRB- - releasing hormone-mediated GH secretion in man .
3919046	0	glucose	14,21	GH	72,74	glucose	GH	MESH:D005947	2688	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|secretion secretion|compound|END_ENTITY	The effect of glucose on growth_hormone -LRB- GH -RRB- - releasing hormone-mediated GH secretion in man .
6360660	0	glucose	67,74	GH	14,16	glucose	GH	MESH:D005947	2688	Chemical	Gene	insulin|appos|START_ENTITY insulin|appos|END_ENTITY	Milk insulin , GH and TSH : relationship to changes in milk lactose , glucose and protein during lactogenesis in women .
7002532	0	glucose	62,69	GH	21,23	glucose	GH	MESH:D005947	2688	Chemical	Gene	metabolism|compound|START_ENTITY bath|nmod|metabolism END_ENTITY|nmod|bath	Effect of endogenous GH secretion during hyperthermic bath on glucose metabolism and insulin release in man .
7590615	0	glucose	36,43	GH	0,2	glucose	GH	MESH:D005947	2688	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	GH response to oral and intravenous glucose load in acromegalic patients .
7962288	0	glucose	16,23	GH	107,109	glucose	GH	MESH:D005947	2688	Chemical	Gene	administration|compound|START_ENTITY Effects|nmod|administration Effects|dep|release release|compound|END_ENTITY	Effects of oral glucose administration on spontaneous and growth_hormone -LRB- GH -RRB- - releasing hormone-stimulated GH release in children and adults .
7962288	0	glucose	16,23	GH	74,76	glucose	GH	MESH:D005947	2688	Chemical	Gene	administration|compound|START_ENTITY administration|nmod|spontaneous spontaneous|appos|END_ENTITY	Effects of oral glucose administration on spontaneous and growth_hormone -LRB- GH -RRB- - releasing hormone-stimulated GH release in children and adults .
11344200	6	glucose	1130,1137	GIP	1105,1108	glucose	GIP	MESH:D005947	2695	Chemical	Gene	changes|compound|START_ENTITY caused|dobj|changes caused|nsubj|Infusion Infusion|nmod|END_ENTITY	Infusion of GIP alone caused neither glucose changes nor elevation of C peptide or insulin levels .
11872663	0	glucose	104,111	GIP	90,93	glucose	GIP	MESH:D005947	25040(Tax:10116)	Chemical	Gene	tolerance|compound|START_ENTITY improves|dobj|tolerance improves|nsubj|D-Ala D-Ala|amod|glucose-dependent_insulinotropic_polypeptide glucose-dependent_insulinotropic_polypeptide|dep|END_ENTITY	Dipeptidyl_peptidase_IV-resistant -LSB- D-Ala -LRB- 2 -RRB- -RSB- glucose-dependent_insulinotropic_polypeptide -LRB- GIP -RRB- improves glucose tolerance in normal and obese diabetic rats .
12189441	0	glucose	62,69	GIP	73,76	glucose	GIP	MESH:D005947	2695	Chemical	Gene	response|nmod|START_ENTITY amplification|nmod|response amplification|nmod|END_ENTITY	Defective amplification of the late phase insulin response to glucose by GIP in obese Type II diabetic patients .
12686467	0	glucose	54,61	GIP	113,116	glucose	GIP	MESH:D005947	2695	Chemical	Gene	clearance|nmod|START_ENTITY reduction|nmod|clearance mediated|nsubjpass|reduction mediated|nmod|polypeptide polypeptide|appos|END_ENTITY	The reduction in hepatic insulin clearance after oral glucose is not mediated by gastric inhibitory polypeptide -LRB- GIP -RRB- .
16046312	0	glucose	111,118	GIP	83,86	glucose	GIP	MESH:D005947	14607(Tax:10090)	Chemical	Gene	tolerance|compound|START_ENTITY improves|dobj|tolerance improves|nsubj|administration administration|compound|END_ENTITY	Chemical ablation of gastric inhibitory polypeptide receptor action by daily -LRB- Pro3 -RRB- GIP administration improves glucose tolerance and ameliorates insulin resistance and abnormalities of islet structure in obesity-related diabetes .
16378704	0	glucose	99,106	GIP	64,67	glucose	GIP	MESH:D005947	14607(Tax:10090)	Chemical	Gene	responsiveness|compound|START_ENTITY restores|dobj|responsiveness restores|nsubj|agonist agonist|appos|END_ENTITY	Stable agonist of glucose-dependent_insulinotropic_polypeptide -LRB- GIP -RRB- restores pancreatic beta cell glucose responsiveness but not glucose intolerance in aging mice .
16435484	0	glucose	34,41	GIP	0,3	glucose	GIP	MESH:D005947	2695	Chemical	Gene	responses|nmod|START_ENTITY responses|nsubj|END_ENTITY	GIP and insulin responses to oral glucose in coeliac patients before and after treatment .
1643802	2	glucose	356,363	GIP	449,452	glucose	GIP	MESH:D005947	2695	Chemical	Gene	ingestion|compound|START_ENTITY ingestion|acl:relcl|due due|xcomp|crossreacting crossreacting|dobj|forms forms|compound|END_ENTITY	However , circulating levels of GIP in diabetes have been reported to be exaggerated , normal or decreased following glucose ingestion , which may be due to the presence of variable crossreacting immunoreactive GIP forms in the circulation .
18283280	0	glucose	115,122	GIP	72,75	glucose	GIP	MESH:D005947	25040(Tax:10116)	Chemical	Gene	load|compound|START_ENTITY blunts|nmod|load blunts|dobj|END_ENTITY	High saturated-fat diet induces apoptosis in rat enterocytes and blunts GIP and insulin-secretive response to oral glucose load .
18455149	5	glucose	840,847	GIP	816,819	glucose	GIP	MESH:D005947	14607(Tax:10090)	Chemical	Gene	-RSB-|nmod|START_ENTITY mPEG|advcl|-RSB- -LSB-|acl|mPEG -LSB-|compound|END_ENTITY	Acute injection of GIP -LSB- mPEG -RSB- together with glucose to high fat fed mice significantly lowered plasma glucose -LRB- p < 0.05 -RRB- and increased plasma insulin responses -LRB- p < 0.05 -RRB- .
18455149	5	glucose	898,905	GIP	816,819	glucose	GIP	MESH:D005947	14607(Tax:10090)	Chemical	Gene	lowered|dobj|START_ENTITY lowered|nsubj|injection injection|nmod|-LSB- -LSB-|compound|END_ENTITY	Acute injection of GIP -LSB- mPEG -RSB- together with glucose to high fat fed mice significantly lowered plasma glucose -LRB- p < 0.05 -RRB- and increased plasma insulin responses -LRB- p < 0.05 -RRB- .
18719661	0	glucose	78,85	GIP	46,49	glucose	GIP	MESH:D005947	14607(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY transepithelial|dobj|transport transepithelial|nsubj|stimulates stimulates|appos|END_ENTITY	Glucose-dependent_insulinotropic_polypeptide -LRB- GIP -RRB- stimulates transepithelial glucose transport .
18937625	0	glucose	80,87	GIP	60,63	glucose	GIP	MESH:D005947	14607(Tax:10090)	Chemical	Gene	control|compound|START_ENTITY improves|dobj|control improves|nsubj|immunisation immunisation|appos|END_ENTITY	Active immunisation against gastric inhibitory polypeptide -LRB- GIP -RRB- improves blood glucose control in an animal model of obesity-diabetes .
19026698	0	glucose	75,82	GIP	10,13	glucose	GIP	MESH:D005947	14607(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY improves|dobj|homeostasis improves|nsubj|activation activation|compound|END_ENTITY	Prolonged GIP receptor activation using stable mini-PEGylated GIP improves glucose homeostasis and beta-cell function in age-related glucose_intolerance .
19026698	0	glucose	75,82	GIP	62,65	glucose	GIP	MESH:D005947	14607(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY improves|dobj|homeostasis improves|nsubj|activation activation|acl|using using|dobj|END_ENTITY	Prolonged GIP receptor activation using stable mini-PEGylated GIP improves glucose homeostasis and beta-cell function in age-related glucose_intolerance .
19614945	4	glucose	1031,1038	GIP	999,1002	glucose	GIP	MESH:D005947	2695	Chemical	Gene	responses|nmod|START_ENTITY responses|compound|END_ENTITY	In contrast , the GIP and GLP-1 responses to oral glucose were different between the groups in a dissociated pattern .
20957343	0	glucose	76,83	GIP	145,148	glucose	GIP	MESH:D005947	2695	Chemical	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Carriers of the TCF7L2 rs7903146 TT genotype have elevated levels of plasma glucose , serum proinsulin and plasma gastric inhibitory polypeptide -LRB- GIP -RRB- during a meal test .
2238756	6	glucose	1078,1085	GIP	1024,1027	glucose	GIP	MESH:D005947	25040(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY alter|nmod|concentration alter|nsubj|END_ENTITY	GIP did not alter somatostatin release at a perfusate glucose concentration of 70 mg/dl while at 150 mg/dl only the highest dose of GIP -LRB- 10 -LRB- -8 -RRB- M -RRB- stimulated somatostatin release significantly .
22651926	0	glucose	88,95	GIP	43,46	glucose	GIP	MESH:D005947	2695	Chemical	Gene	transport|nmod|START_ENTITY reducing|dobj|transport postprandial|advcl|reducing postprandial|dobj|release release|compound|END_ENTITY	Dietary 1-monoolein decreases postprandial GIP release by reducing jejunal transport of glucose and fatty_acid in rodents .
24164718	0	glucose	58,65	GIP	151,154	glucose	GIP	MESH:D005947	2695	Chemical	Gene	b-cells|nmod|START_ENTITY Effects|nmod|b-cells Effects|nmod|END_ENTITY	Effects of chronic exposure of clonal b-cells to elevated glucose and free fatty_acids on incretin receptor gene expression and secretory responses to GIP and GLP-1 .
25271113	0	glucose	102,109	GIP	23,26	glucose	GIP	MESH:D005947	2695	Chemical	Gene	tolerance|compound|START_ENTITY subjects|nmod|tolerance load|nmod|subjects Response|nmod|load Response|appos|END_ENTITY	Response of incretins -LRB- GIP and GLP-1 -RRB- to an oral glucose load in female and male subjects with normal glucose tolerance .
25271113	0	glucose	49,56	GIP	23,26	glucose	GIP	MESH:D005947	2695	Chemical	Gene	load|compound|START_ENTITY Response|nmod|load Response|appos|END_ENTITY	Response of incretins -LRB- GIP and GLP-1 -RRB- to an oral glucose load in female and male subjects with normal glucose tolerance .
25399343	0	glucose	108,115	GIP	76,79	glucose	GIP	MESH:D005947	2695	Chemical	Gene	intraduodenal|dobj|START_ENTITY responses|xcomp|intraduodenal responses|nsubj|disparities disparities|appos|END_ENTITY	Ethnic disparities in insulin and glucose-dependent_insulinotropic_peptide -LRB- GIP -RRB- responses to intraduodenal glucose in health .
26041107	8	glucose	1386,1393	GIP	1421,1424	glucose	GIP	MESH:D005947	25040(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY attenuate|dobj|transport attenuate|advcl|suggesting suggesting|ccomp|signaling signaling|nsubj|END_ENTITY	However , the specific GIP receptor antagonist -LRB- Pro -LRB- 3 -RRB- -RRB- GIP did not attenuate GIP-stimulated glucose transport , suggesting that GIP is not signaling through its classical receptor .
3146539	0	glucose	28,35	GIP	103,106	glucose	GIP	MESH:D005947	2695	Chemical	Gene	Suppression|nmod|START_ENTITY Suppression|appos|END_ENTITY	Suppression of postprandial glucose , insulin , C-peptide , and glucose-dependent_insulinotropic_peptide -LRB- GIP -RRB- in man by oral administration of a prostaglandin analogue -LRB- enprostil -RRB- .
3516833	0	glucose	48,55	GIP	10,13	glucose	GIP	MESH:D005947	25040(Tax:10116)	Chemical	Gene	infusion|compound|START_ENTITY release|nmod|infusion release|nsubj|Effect Effect|nmod|END_ENTITY	Effect of GIP on insulin release to intravenous glucose infusion in hyperthyroid rats .
3902421	0	glucose	58,65	GIP	32,35	glucose	GIP	MESH:D005947	2695	Chemical	Gene	ingestion|compound|START_ENTITY polypeptide|nmod|ingestion polypeptide|dobj|responses responses|appos|END_ENTITY	Gastric inhibitory polypeptide -LRB- GIP -RRB- responses after oral glucose ingestion in hyperthyroidism .
3979679	0	glucose	67,74	GIP	30,33	glucose	GIP	MESH:D005947	609020(Tax:9615)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Effect Effect|nmod|vagotomy vagotomy|nmod|release release|compound|END_ENTITY	Effect of truncal vagotomy on GIP release induced by intraduodenal glucose or fat in dogs .
6127273	3	glucose	662,669	GIP	715,718	glucose	GIP	MESH:D005947	2695	Chemical	Gene	ingestion|nmod|START_ENTITY infused|nmod|ingestion dose|acl|infused decreased|nsubj|dose decreased|dobj|levels levels|nmod|END_ENTITY	The same somatostatin dose infused 30 min after the ingestion of glucose decreased significantly the raised levels of GIP and insulin and further increased blood glucose levels .
6344327	0	glucose	57,64	GIP	32,35	glucose	GIP	MESH:D005947	2695	Chemical	Gene	load|compound|START_ENTITY Gastric|nmod|load Gastric|dobj|response response|amod|polypeptide polypeptide|dep|END_ENTITY	Gastric inhibitory polypeptide -LRB- GIP -RRB- response to an oral glucose load in the patients with diabetes_mellitus .
6354520	0	glucose	60,67	GIP	51,54	glucose	GIP	MESH:D005947	2695	Chemical	Gene	dependent|advmod|START_ENTITY hormone|amod|dependent END_ENTITY|nmod|hormone	The evidence for the regulatory role of endogenous GIP as a glucose dependent insulinotropic hormone in patients with duodenal ulcer .
6357919	0	glucose	57,64	GIP	36,39	glucose	GIP	MESH:D005947	2695	Chemical	Gene	influence|nmod|START_ENTITY influence|dobj|response response|compound|END_ENTITY	Failure of fasting to influence the GIP response to oral glucose in non-obese human subjects .
6752641	0	glucose	93,100	GIP	32,35	glucose	GIP	MESH:D005947	2695	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|Gastric_inhibitory_polypeptide Gastric_inhibitory_polypeptide|appos|END_ENTITY	Gastric_inhibitory_polypeptide -LRB- GIP -RRB- and insulin release in response to oral and intravenous glucose in uremic patients .
6753108	0	glucose	97,104	GIP	66,69	glucose	GIP	MESH:D005947	2695	Chemical	Gene	correlation|nmod|START_ENTITY correlation|nmod|END_ENTITY	The correlation between gastric emptying time and the response of GIP and enteroglucagon to oral glucose in duodenal ulcer patients .
7001614	0	glucose	76,83	GIP	32,35	glucose	GIP	MESH:D005947	2695	Chemical	Gene	effect|nmod|START_ENTITY release|dobj|effect release|nsubj|polypeptide polypeptide|appos|END_ENTITY	Gastric inhibitory polypeptide -LRB- GIP -RRB- release and incretin effect after oral glucose in obesity and after jejunoileal bypass .
7014042	0	glucose	43,50	GIP	98,101	glucose	GIP	MESH:D005947	2695	Chemical	Gene	doses|nmod|START_ENTITY effect|nmod|doses polypeptide|nsubj|effect polypeptide|dobj|concentrations concentrations|appos|END_ENTITY	The effect of increasing doses of ingested glucose on insulin and gastric inhibitory polypeptide -LRB- GIP -RRB- concentrations in man .
7015475	0	glucose	58,65	GIP	31,34	glucose	GIP	MESH:D005947	2695	Chemical	Gene	association|nmod|START_ENTITY association|nmod|END_ENTITY	The association between plasma GIP and insulin after oral glucose .
7015476	0	glucose	92,99	GIP	62,65	glucose	GIP	MESH:D005947	2695	Chemical	Gene	START_ENTITY|amod|fast fast|nmod|rises rises|nmod|END_ENTITY	The effect of a 34-h fast on the meal-induced rises in plasma GIP , serum insulin , and blood glucose in man .
7029674	0	glucose	77,84	GIP	55,58	glucose	GIP	MESH:D005947	2695	Chemical	Gene	ingestion|compound|START_ENTITY gastric-inhibitory_polypeptide|nmod|ingestion gastric-inhibitory_polypeptide|appos|END_ENTITY	The response of plasma gastric-inhibitory_polypeptide -LRB- GIP -RRB- to slow and fast glucose ingestion in Billroth II resected patients and normal controls .
7134635	0	glucose	89,96	GIP	43,46	glucose	GIP	MESH:D005947	2695	Chemical	Gene	load|compound|START_ENTITY meal|nmod|load polypeptide|nmod|meal polypeptide|dep|END_ENTITY	Release of gastric inhibitory polypeptide -LRB- GIP -RRB- and gastrin after a test meal with a low glucose load in patients after BII resection , proximal duodenopancreatectomy -LRB- PDP -RRB- and jejunoileal bypass .
8822268	0	glucose	14,21	GIP	0,3	glucose	GIP	MESH:D005947	2695	Chemical	Gene	hexokinases|compound|START_ENTITY regulates|dobj|hexokinases regulates|nsubj|END_ENTITY	GIP regulates glucose transporters , hexokinases , and glucose-induced insulin secretion in RIN 1046-38 cells .
9211887	1	glucose	256,263	GIP	171,174	glucose	GIP	MESH:D005947	14607(Tax:10090)	Chemical	Gene	presence|nmod|START_ENTITY stimulates|nmod|presence peptide|acl:relcl|stimulates peptide|nsubj|Glucose-dependent_insulinotropic_polypeptide Glucose-dependent_insulinotropic_polypeptide|appos|END_ENTITY	Glucose-dependent_insulinotropic_polypeptide -LRB- GIP -RRB- is a 42-amino_acid gastrointestinal regulatory peptide that , in the presence of glucose , stimulates insulin secretion .
9279024	0	glucose	84,91	GIP	56,59	glucose	GIP	MESH:D005947	2695	Chemical	Gene	response|nmod|START_ENTITY Effect|nmod|response Effect|appos|END_ENTITY	Effect of glucose-dependent_insulinotropic_polypeptide -LRB- GIP -RRB- on insulin response to glucose in acromegalics .
11004015	0	glucose	69,76	GLP-1	7,12	glucose	GLP-1	MESH:D005947	24952(Tax:10116)	Chemical	Gene	augments|nmod|START_ENTITY augments|nsubj|administration administration|compound|END_ENTITY	Portal GLP-1 administration in rats augments the insulin response to glucose via neuronal mechanisms .
12679472	0	glucose	78,85	GLP-1	11,16	glucose	GLP-1	MESH:D005947	2641	Chemical	Gene	tolerance|compound|START_ENTITY NH2|nmod|tolerance NH2|nsubj|Effects Effects|nmod|END_ENTITY	Effects of GLP-1 - -LRB- 7-36 -RRB- NH2 , GLP-1 - -LRB- 7-37 -RRB- , and GLP-1 - -LRB- 9-36 -RRB- NH2 on intravenous glucose tolerance and glucose-induced insulin secretion in healthy humans .
12679472	0	glucose	78,85	GLP-1	28,33	glucose	GLP-1	MESH:D005947	2641	Chemical	Gene	tolerance|compound|START_ENTITY NH2|nmod|tolerance NH2|nsubj|Effects Effects|nmod|GLP-1 GLP-1|dep|NH2 NH2|appos|END_ENTITY	Effects of GLP-1 - -LRB- 7-36 -RRB- NH2 , GLP-1 - -LRB- 7-37 -RRB- , and GLP-1 - -LRB- 9-36 -RRB- NH2 on intravenous glucose tolerance and glucose-induced insulin secretion in healthy humans .
12773303	0	glucose	15,22	GLP-1	37,42	glucose	GLP-1	MESH:D005947	2641	Chemical	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Suppression of glucose production by GLP-1 independent of islet hormones : a novel extrapancreatic effect .
12829647	0	glucose	62,69	GLP-1	4,9	glucose	GLP-1	MESH:D005947	24952(Tax:10116)	Chemical	Gene	restores|nmod|START_ENTITY restores|nsubj|NN2211 NN2211|compound|END_ENTITY	The GLP-1 derivative NN2211 restores beta-cell sensitivity to glucose in type 2 diabetic patients after a single dose .
12832099	0	glucose	64,71	GLP-1	5,10	glucose	GLP-1	MESH:D005947	2641	Chemical	Gene	levels|compound|START_ENTITY insulinotropic|nmod|levels insulinotropic|nsubj|END_ENTITY	Both GLP-1 and GIP are insulinotropic at basal and postprandial glucose levels and contribute nearly equally to the incretin effect of a meal in healthy subjects .
15026303	0	glucose	53,60	GLP-1	31,36	glucose	GLP-1	MESH:D005947	403571(Tax:9615)	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	Insulin-independent effects of GLP-1 on canine liver glucose metabolism : duration of infusion and involvement of hepatoportal region .
15180341	0	glucose	17,24	GLP-1	34,39	glucose	GLP-1	MESH:D005947	24952(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|delivery delivery|compound|END_ENTITY	Control of blood glucose by novel GLP-1 delivery using biodegradable triblock copolymer of PLGA-PEG-PLGA in type 2 diabetic rats .
15212985	0	glucose	82,89	GLP-1	46,51	glucose	GLP-1	MESH:D005947	14526(Tax:10090)	Chemical	Gene	levels|compound|START_ENTITY affect|dobj|levels affect|nsubj|metabolite metabolite|appos|END_ENTITY	The major glucagon-like_peptide-1 metabolite , GLP-1 - -LRB- 9-36 -RRB- - amide , does not affect glucose or insulin levels in mice .
15664668	0	glucose	19,26	GLP-1	10,15	glucose	GLP-1	MESH:D005947	2641	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|nmod|transport	Effect of GLP-1 on glucose transport and its cell signalling in human myocytes .
15686481	0	glucose	80,87	GLP-1	71,76	glucose	GLP-1	MESH:D005947	100125288	Chemical	Gene	metabolism|compound|START_ENTITY allows|nmod|metabolism allows|dobj|effect effect|nmod|END_ENTITY	The expression of GLP-1_receptor mRNA and protein allows the effect of GLP-1 on glucose metabolism in the human hypothalamus and brainstem .
16024574	0	glucose	47,54	GLP-1	21,26	glucose	GLP-1	MESH:D005947	403571(Tax:9615)	Chemical	Gene	uptake|compound|START_ENTITY mediates|dobj|uptake mediates|nsubj|metabolite metabolite|nmod|END_ENTITY	Active metabolite of GLP-1 mediates myocardial glucose uptake and improves left ventricular performance in conscious dogs with dilated_cardiomyopathy .
16051922	0	glucose	63,70	GLP-1	109,114	glucose	GLP-1	MESH:D005947	403571(Tax:9615)	Chemical	Gene	metabolism|compound|START_ENTITY GLP-1|nmod|metabolism effects|nmod|GLP-1 involve|nsubj|effects involve|dobj|receptors receptors|compound|END_ENTITY	Insulin secretion-independent effects of GLP-1 on canine liver glucose metabolism do not involve portal vein GLP-1 receptors .
16051922	0	glucose	63,70	GLP-1	41,46	glucose	GLP-1	MESH:D005947	403571(Tax:9615)	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	Insulin secretion-independent effects of GLP-1 on canine liver glucose metabolism do not involve portal vein GLP-1 receptors .
16142415	0	glucose	32,39	GLP-1	0,5	glucose	GLP-1	MESH:D005947	100125288	Chemical	Gene	metabolism|compound|START_ENTITY signalling|nmod|metabolism signalling|compound|END_ENTITY	GLP-1 signalling and effects on glucose metabolism in myocytes from type 2 diabetic patients .
16322789	0	glucose	37,44	GLP-1	18,23	glucose	GLP-1	MESH:D005947	2641	Chemical	Gene	regulate|dobj|START_ENTITY regulate|nsubj|END_ENTITY	New ways in which GLP-1 can regulate glucose homeostasis .
16648370	0	glucose	96,103	GLP-1	31,36	glucose	GLP-1	MESH:D005947	14526(Tax:10090)	Chemical	Gene	tolerance|compound|START_ENTITY improvements|nmod|tolerance results|nmod|improvements results|amod|glucagon-like_peptide-1 glucagon-like_peptide-1|dep|END_ENTITY	Novel glucagon-like_peptide-1 -LRB- GLP-1 -RRB- analog -LRB- Val8 -RRB- GLP-1 results in significant improvements of glucose tolerance and pancreatic beta-cell function after 3-week daily administration in obese diabetic -LRB- ob/ob -RRB- mice .
16648370	0	glucose	96,103	GLP-1	51,56	glucose	GLP-1	MESH:D005947	14526(Tax:10090)	Chemical	Gene	tolerance|compound|START_ENTITY improvements|nmod|tolerance results|nmod|improvements results|compound|END_ENTITY	Novel glucagon-like_peptide-1 -LRB- GLP-1 -RRB- analog -LRB- Val8 -RRB- GLP-1 results in significant improvements of glucose tolerance and pancreatic beta-cell function after 3-week daily administration in obese diabetic -LRB- ob/ob -RRB- mice .
16648370	5	glucose	890,897	GLP-1	844,849	glucose	GLP-1	MESH:D005947	14526(Tax:10090)	Chemical	Gene	concentrations|compound|START_ENTITY reduced|dobj|concentrations reduced|nsubj|administration administration|nmod|END_ENTITY	Once-daily subcutaneous administration of -LRB- Val8 -RRB- GLP-1 -LRB- 25 nmol/kg -RRB- for 21 days reduced plasma glucose concentrations , increased plasma insulin , and reduced body weight more than native GLP-1 without a significant change in daily food intake .
16720628	0	glucose	56,63	GLP-1	145,150	glucose	GLP-1	MESH:D005947	403571(Tax:9615)	Chemical	Gene	rises|nmod|START_ENTITY produce|nsubj|rises produce|advcl|suggesting suggesting|dobj|mechanism mechanism|nmod|action action|compound|END_ENTITY	Exogenously imposed postprandial-like rises in systemic glucose and GLP-1 do not produce an incretin effect , suggesting an indirect mechanism of GLP-1 action .
16943856	0	glucose	81,88	GLP-1	39,44	glucose	GLP-1	MESH:D005947	14526(Tax:10090)	Chemical	Gene	levels|compound|START_ENTITY normalizes|dobj|levels therapy|parataxis|normalizes therapy|nmod|diabetes diabetes|acl|using using|dobj|END_ENTITY	Gene therapy of diabetes using a novel GLP-1 / IgG1-Fc fusion construct normalizes glucose levels in db/db mice .
17184947	0	glucose	110,117	GLP-1	73,78	glucose	GLP-1	MESH:D005947	14526(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY effects|nmod|homeostasis effects|nmod|receptors receptors|appos|END_ENTITY	Beneficial effects of sub-chronic activation of glucagon-like_peptide-1 -LRB- GLP-1 -RRB- receptors on deterioration of glucose homeostasis and insulin secretion in aging mice .
17217635	0	glucose	21,28	GLP-1	0,5	glucose	GLP-1	MESH:D005947	2641	Chemical	Gene	tolerance|compound|START_ENTITY END_ENTITY|nmod|tolerance	GLP-1 and changes in glucose tolerance following gastric bypass surgery in morbidly obese subjects .
17487430	0	glucose	38,45	GLP-1	14,19	glucose	GLP-1	MESH:D005947	2641	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|nmod|transport	The action of GLP-1 and exendins upon glucose transport in normal human adipocytes , and on kinase activity as compared to morbidly obese patients .
17584962	0	glucose	133,140	GLP-1	124,129	glucose	GLP-1	MESH:D005947	24952(Tax:10116)	Chemical	Gene	tolerance|compound|START_ENTITY mediate|nmod|tolerance mediate|dobj|effects effects|nmod|END_ENTITY	Glucagon-like_peptide-1 -LRB- GLP-1 -RRB- receptors expressed on nerve terminals in the portal vein mediate the effects of endogenous GLP-1 on glucose tolerance in rats .
17584962	0	glucose	133,140	GLP-1	25,30	glucose	GLP-1	MESH:D005947	24952(Tax:10116)	Chemical	Gene	tolerance|compound|START_ENTITY mediate|nmod|tolerance expressed|dep|mediate expressed|nsubj|receptors receptors|appos|END_ENTITY	Glucagon-like_peptide-1 -LRB- GLP-1 -RRB- receptors expressed on nerve terminals in the portal vein mediate the effects of endogenous GLP-1 on glucose tolerance in rats .
17684104	0	glucose	48,55	GLP-1	12,17	glucose	GLP-1	MESH:D005947	403571(Tax:9615)	Chemical	Gene	utilization|compound|START_ENTITY increases|dobj|utilization increases|nsubj|infusion infusion|compound|END_ENTITY	Intraportal GLP-1 infusion increases nonhepatic glucose utilization without changing pancreatic hormone levels .
18056788	0	glucose	132,139	GLP-1	24,29	glucose	GLP-1	MESH:D005947	403571(Tax:9615)	Chemical	Gene	utilization|compound|START_ENTITY change|dobj|utilization change|dep|delivered delivered|xcomp|END_ENTITY	Intraportally delivered GLP-1 , in the presence of hyperglycemia induced via peripheral_glucose_infusion , does not change whole body glucose utilization .
1807008	3	glucose	683,690	GLP-1	606,611	glucose	GLP-1	MESH:D005947	403571(Tax:9615)	Chemical	Gene	infusion|compound|START_ENTITY enhanced|nmod|infusion enhanced|nsubj|END_ENTITY	GLP-1 -LRB- 7-36 -RRB- and -LRB- 7-37 -RRB- , as well as glucagon enhanced insulin release during glucose infusion , whereas neither GLP-1 -LRB- 1-37 -RRB- , -LRB- 7-20 -RRB- , -LRB- 6-37 -RRB- nor -LRB- 8-37 -RRB- stimulated insulin release .
18200618	0	glucose	45,52	GLP-1	0,5	glucose	GLP-1	MESH:D005947	24952(Tax:10116)	Chemical	Gene	lowering-function|compound|START_ENTITY affect|dobj|lowering-function affect|nsubj|structures structures|compound|END_ENTITY	GLP-1 C-terminal structures affect its blood glucose lowering-function .
18292985	0	glucose	28,35	GLP-1	72,77	glucose	GLP-1	MESH:D005947	2641	Chemical	Gene	normalisation|nmod|START_ENTITY improves|nmod|normalisation improves|nsubj|effect effect|nmod|END_ENTITY	Near normalisation of blood glucose improves the potentiating effect of GLP-1 on glucose-induced insulin secretion in patients with type 2 diabetes .
18508100	0	glucose	35,42	GLP-1	4,9	glucose	GLP-1	MESH:D005947	100125288	Chemical	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	CNS GLP-1 regulation of peripheral glucose homeostasis .
18575785	0	glucose	50,57	GLP-1	19,24	glucose	GLP-1	MESH:D005947	24952(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY Characteristics|nmod|transport Characteristics|nmod|action action|amod|END_ENTITY	Characteristics of GLP-1 and exendins action upon glucose transport and metabolism in type 2 diabetic rat skeletal muscle .
19046215	0	glucose	42,49	GLP-1	80,85	glucose	GLP-1	MESH:D005947	2641	Chemical	Gene	near-normalization|nmod|START_ENTITY weeks|nmod|near-normalization has|nsubj|weeks has|dobj|effect effect|nmod|END_ENTITY	Four weeks of near-normalization of blood glucose has no effect on postprandial GLP-1 and GIP secretion , but augments pancreatic B-cell responsiveness to a meal in patients with Type 2 diabetes .
20005261	0	glucose	74,81	GLP-1	34,39	glucose	GLP-1	MESH:D005947	100125288	Chemical	Gene	responses|nmod|START_ENTITY responses|nmod|END_ENTITY	Pancreatic beta-cell responses to GLP-1 after near-normalization of blood glucose in patients with type 2 diabetes .
20645222	0	glucose	45,52	GLP-1	0,5	glucose	GLP-1	MESH:D005947	14526(Tax:10090)	Chemical	Gene	production|compound|START_ENTITY suppression|nmod|production amide|dobj|suppression amide|nsubj|END_ENTITY	GLP-1 -LRB- 9-36 -RRB- amide metabolite suppression of glucose production in isolated mouse hepatocytes .
21153123	7	glucose	1247,1254	GLP-1	1175,1180	glucose	GLP-1	MESH:D005947	24952(Tax:10116)	Chemical	Gene	stimulate|nmod|START_ENTITY stimulate|nsubj|10 10|dep|END_ENTITY	However , 10 -LRB- -8 -RRB- M GLP-1 -LRB- 7-36NH2 -RRB- did not stimulate insulin secretion at either 5 or 10 mM glucose , or in the presence of forskolin and IBMX .
21281062	0	glucose	87,94	GLP-1	45,50	glucose	GLP-1	MESH:D005947	24952(Tax:10116)	Chemical	Gene	test|compound|START_ENTITY decreases|nmod|test decreases|dobj|effects effects|compound|END_ENTITY	DPP-4 inhibition increases GIP and decreases GLP-1 incretin effects during intravenous glucose tolerance test in Wistar_rats .
21340616	0	glucose	94,101	GLP-1	46,51	glucose	GLP-1	MESH:D005947	2641	Chemical	Gene	levels|compound|START_ENTITY improves|dobj|levels improves|nsubj|liraglutide liraglutide|amod|glucagon-like_peptide-1 glucagon-like_peptide-1|dep|END_ENTITY	The once-daily human glucagon-like_peptide-1 -LRB- GLP-1 -RRB- analog liraglutide improves postprandial glucose levels in type 2 diabetes patients .
21419173	0	glucose	35,42	GLP-1	18,23	glucose	GLP-1	MESH:D005947	100125288	Chemical	Gene	metabolism|compound|START_ENTITY Characteristic|nmod|metabolism Characteristic|nmod|effects effects|compound|END_ENTITY	Characteristic of GLP-1 effects on glucose metabolism in human skeletal muscle from obese patients .
21547512	0	glucose	68,75	GLP-1	22,27	glucose	GLP-1	MESH:D005947	403571(Tax:9615)	Chemical	Gene	regulation|compound|START_ENTITY alter|dobj|regulation sufficient|xcomp|alter sufficient|nsubj|END_ENTITY	Endogenously released GLP-1 is not sufficient to alter postprandial glucose regulation in the dog .
21673955	0	glucose	22,29	GLP-1	38,43	glucose	GLP-1	MESH:D005947	14526(Tax:10090)	Chemical	Gene	secretion|compound|START_ENTITY secretion|compound|END_ENTITY	Resveratrol increases glucose induced GLP-1 secretion in mice : a mechanism which contributes to the glycemic control .
21677044	0	glucose	40,47	GLP-1	126,131	glucose	GLP-1	MESH:D005947	2641	Chemical	Gene	uptake|compound|START_ENTITY visfatin|nmod|uptake suppression|nmod|visfatin evidence|nmod|suppression evidence|nmod|effect effect|nmod|glucagon-like_peptide-1 glucagon-like_peptide-1|appos|END_ENTITY	In vivo suppression of visfatin by oral glucose uptake : evidence for a novel incretin-like effect by glucagon-like_peptide-1 -LRB- GLP-1 -RRB- .
21846600	5	glucose	780,787	GLP-1	816,821	glucose	GLP-1	MESH:D005947	2641	Chemical	Gene	competence|compound|START_ENTITY competence|nmod|cells cells|nmod|END_ENTITY	To understand how this model couples to cellular events , we use a previously published mechanistic model of insulin secretion , and show mathematically that induction of glucose competence in beta cells by GLP-1 can underlie derivative control by GLP-1 .
21922329	0	glucose	119,126	GLP-1	86,91	glucose	GLP-1	MESH:D005947	100125288	Chemical	Gene	test|compound|START_ENTITY response|nmod|test response|compound|END_ENTITY	Mechanism-based population modelling for assessment of L-cell function based on total GLP-1 response following an oral glucose tolerance test .
22120833	0	glucose	89,96	GLP-1	0,5	glucose	GLP-1	MESH:D005947	100125288	Chemical	Gene	endoplasmic_reticulum_stress|compound|START_ENTITY cells|nmod|endoplasmic_reticulum_stress protects|dobj|cells protects|nsubj|Liraglutide Liraglutide|compound|END_ENTITY	GLP-1 analogue , Liraglutide protects human umbilical vein endothelial cells against high glucose induced endoplasmic_reticulum_stress .
22198816	0	glucose	56,63	GLP-1	10,15	glucose	GLP-1	MESH:D005947	14526(Tax:10090)	Chemical	Gene	gavage-administration|nmod|START_ENTITY response|nmod|gavage-administration response|compound|END_ENTITY	Increased GLP-1 response after gavage-administration of glucose in UCP2-deficient mice .
22233527	0	glucose	72,79	GLP-1	0,5	glucose	GLP-1	MESH:D005947	2641	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|dep|effects	GLP-1 based therapies : differential effects on fasting and postprandial glucose .
22626875	0	glucose	130,137	GLP-1	37,42	glucose	GLP-1	MESH:D005947	24952(Tax:10116)	Chemical	Gene	homeostasis|compound|START_ENTITY resulting|nmod|homeostasis ameliorates|xcomp|resulting ameliorates|dobj|END_ENTITY	Vildagliptin selectively ameliorates GLP-1 , GLUT4 , SREBP-1c mRNA levels and stimulates b-cell proliferation resulting in improved glucose homeostasis in rats with streptozotocin-induced diabetes .
22774207	8	glucose	1268,1275	GLP-1	1245,1250	glucose	GLP-1	MESH:D005947	2641	Chemical	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	RESULTS : The patient had high levels of glucagon and GLP-1 with an exaggerated GLP-1 response to oral glucose .
23064290	0	glucose	46,53	GLP-1	17,22	glucose	GLP-1	MESH:D005947	2641	Chemical	Gene	production|compound|START_ENTITY effect|nmod|production effect|nmod|infusion infusion|compound|END_ENTITY	Direct effect of GLP-1 infusion on endogenous glucose production in humans .
23543638	0	glucose	51,58	GLP-1	25,30	glucose	GLP-1	MESH:D005947	2641	Chemical	Gene	capacity|compound|START_ENTITY raises|dobj|capacity raises|nsubj|Glucagon-like_peptide-1 Glucagon-like_peptide-1|appos|END_ENTITY	Glucagon-like_peptide-1 -LRB- GLP-1 -RRB- raises blood-brain glucose transfer capacity and hexokinase activity in human brain .
23618969	1	glucose	278,285	GLP-1	192,197	glucose	GLP-1	MESH:D005947	14526(Tax:10090)	Chemical	Gene	level|compound|START_ENTITY regulates|advcl|level hormone|acl:relcl|regulates hormone|nsubj|Glucagon-like_peptide-1 Glucagon-like_peptide-1|appos|END_ENTITY	Glucagon-like_peptide-1 -LRB- GLP-1 -RRB- is an incretin hormone that regulates the insulin secretion depending on blood glucose level .
23711193	0	glucose	21,28	GLP-1	116,121	glucose	GLP-1	MESH:D005947	2641	Chemical	Gene	management|compound|START_ENTITY Options|nmod|management Options|dep|addition addition|nmod|analogue analogue|compound|END_ENTITY	Options for prandial glucose management in type 2 diabetes patients using basal insulin : addition of a short-acting GLP-1 analogue versus progression to basal-bolus therapy .
23959939	0	glucose	54,61	GLP-1	27,32	glucose	GLP-1	MESH:D005947	14526(Tax:10090)	Chemical	Gene	tolerance|compound|START_ENTITY improve|dobj|tolerance stimulates|advcl|improve stimulates|dobj|secretion secretion|compound|END_ENTITY	Oral L-arginine stimulates GLP-1 secretion to improve glucose tolerance in male mice .
24290838	0	glucose	130,137	GLP-1	44,49	glucose	GLP-1	MESH:D005947	2641	Chemical	Gene	test|compound|START_ENTITY compared|nmod|test compared|nsubj|insulin insulin|appos|END_ENTITY	Higher insulin and glucagon-like peptide-1 -LRB- GLP-1 -RRB- levels in healthy , young South Asians as compared to Caucasians during an oral glucose tolerance test .
24373234	0	glucose	14,21	GLP-1	37,42	glucose	GLP-1	MESH:D005947	100125288	Chemical	Gene	Regulation|nmod|START_ENTITY homeostasis|nsubj|Regulation homeostasis|nmod|END_ENTITY	Regulation of glucose homeostasis by GLP-1 .
24400077	0	glucose	33,40	GLP-1	13,18	glucose	GLP-1	MESH:D005947	2641	Chemical	Gene	metabolism|compound|START_ENTITY Influence|nmod|metabolism Influence|nmod|END_ENTITY	Influence of GLP-1 on myocardial glucose metabolism in healthy men during normo - or hypoglycemia .
24583245	0	glucose	64,71	GLP-1	0,5	glucose	GLP-1	MESH:D005947	14526(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|dep|effects	GLP-1 released to the mesenteric lymph duct in mice : effects of glucose and fat .
24684709	0	glucose	142,149	GLP-1	94,99	glucose	GLP-1	MESH:D005947	2641	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	At the centennial of Michaelis and Menten , competing Michaelis-Menten steps explain effect of GLP-1 on blood-brain transfer and metabolism of glucose .
24859892	0	glucose	91,98	GLP-1	0,5	glucose	GLP-1	MESH:D005947	2641	Chemical	Gene	concentrations|compound|START_ENTITY inhibited|nmod|concentrations ameliorates|ccomp|inhibited ameliorates|nsubj|END_ENTITY	GLP-1 ameliorates the proliferation activity of INS-1 cells inhibited by intermittent high glucose concentrations through the regulation of cyclins .
24937653	0	glucose	88,95	GLP-1	0,5	glucose	GLP-1	MESH:D005947	403571(Tax:9615)	Chemical	Gene	metabolism|compound|START_ENTITY modulates|dobj|metabolism modulates|nsubj|END_ENTITY	GLP-1 -LRB- 32-36 -RRB- amide , a novel pentapeptide cleavage product of GLP-1 , modulates whole body glucose metabolism in dogs .
24937653	0	glucose	88,95	GLP-1	60,65	glucose	GLP-1	MESH:D005947	403571(Tax:9615)	Chemical	Gene	metabolism|compound|START_ENTITY modulates|dobj|metabolism modulates|nsubj|GLP-1 GLP-1|appos|product product|nmod|END_ENTITY	GLP-1 -LRB- 32-36 -RRB- amide , a novel pentapeptide cleavage product of GLP-1 , modulates whole body glucose metabolism in dogs .
25144632	0	glucose	114,121	GLP-1	35,40	glucose	GLP-1	MESH:D005947	2641	Chemical	Gene	causes|nmod|START_ENTITY causes|nsubj|Combination Combination|nmod|amide amide|amod|peptide_YY3-36 peptide_YY3-36|nmod|END_ENTITY	Combination of peptide_YY3-36 with GLP-1 -LRB- 7-36 -RRB- amide causes an increase in first-phase insulin secretion after IV glucose .
25338812	0	glucose	24,31	GLP-1	58,63	glucose	GLP-1	MESH:D005947	14526(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY improves|dobj|homeostasis improves|nmod|END_ENTITY	Loss of Cyp8b1 improves glucose homeostasis by increasing GLP-1 .
25843210	0	glucose	122,129	GLP-1	76,81	glucose	GLP-1	MESH:D005947	24952(Tax:10116)	Chemical	Gene	homeostasis|compound|START_ENTITY channels|nmod|homeostasis channels|compound|END_ENTITY	Acute effect of 3b-hidroxihop-22 -LRB- 29 -RRB- ene on insulin secretion is mediated by GLP-1 , potassium and calcium channels for the glucose homeostasis .
25843210	0	glucose	122,129	GLP-1	76,81	glucose	GLP-1	MESH:D005947	24952(Tax:10116)	Chemical	Gene	homeostasis|compound|START_ENTITY channels|nmod|homeostasis channels|compound|END_ENTITY	Acute effect of 3b-hidroxihop-22 -LRB- 29 -RRB- ene on insulin secretion is mediated by GLP-1 , potassium and calcium channels for the glucose homeostasis .
26680669	0	glucose	14,21	GLP-1	91,96	glucose	GLP-1	MESH:D005947	2641	Chemical	Gene	effect|nmod|START_ENTITY added|nsubj|effect added|dep|END_ENTITY	The effect of glucose when added to a fat load on the response of glucagon-like_peptide-1 -LRB- GLP-1 -RRB- and apolipoprotein_B-48 in the postprandial phase .
26786780	0	glucose	39,46	GLP-1	22,27	glucose	GLP-1	MESH:D005947	2641	Chemical	Gene	tolerance|compound|START_ENTITY Effects|nmod|tolerance Effects|nmod|END_ENTITY	Effects of endogenous GLP-1 and GIP on glucose tolerance after Roux-en-Y gastric bypass surgery .
27055279	0	glucose	25,32	GLP-1	102,107	glucose	GLP-1	MESH:D005947	100125288	Chemical	Gene	tolerance|compound|START_ENTITY impairs|dobj|tolerance impairs|nmod|END_ENTITY	Ghrelin impairs prandial glucose tolerance and insulin secretion in healthy humans despite increasing GLP-1 .
7956929	0	glucose	72,79	GLP-1	163,168	glucose	GLP-1	MESH:D005947	24952(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|dep|one one|nmod|sites sites|nmod|action action|compound|END_ENTITY	Glucagon-like_peptide-1 -LRB- 7-36 -RRB- amide -LRB- GLP-1 -RRB- enhances insulin-stimulated glucose metabolism in 3T3-L1 adipocytes : one of several potential extrapancreatic sites of GLP-1 action .
7956929	0	glucose	72,79	GLP-1	37,42	glucose	GLP-1	MESH:D005947	24952(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY enhances|dobj|metabolism enhances|nsubj|amide amide|appos|END_ENTITY	Glucagon-like_peptide-1 -LRB- 7-36 -RRB- amide -LRB- GLP-1 -RRB- enhances insulin-stimulated glucose metabolism in 3T3-L1 adipocytes : one of several potential extrapancreatic sites of GLP-1 action .
8530635	2	glucose	265,272	GLP-1	239,244	glucose	GLP-1	MESH:D005947	2641	Chemical	Gene	sensitivity|compound|START_ENTITY correct|dobj|sensitivity able|xcomp|correct able|nsubj|Glucagon-like_peptide-1 Glucagon-like_peptide-1|appos|END_ENTITY	Glucagon-like_peptide-1 -LRB- GLP-1 -RRB- is able to correct glucose sensitivity in some models of glucose-resistant beta-cells .
8550773	0	glucose	18,25	GLP-1	131,136	glucose	GLP-1	MESH:D005947	2641	Chemical	Gene	responses|compound|START_ENTITY emptying|appos|responses emptying|dep|effects effects|nmod|exogenous exogenous|appos|END_ENTITY	Gastric emptying , glucose responses , and insulin secretion after a liquid test meal : effects of exogenous glucagon-like_peptide-1 -LRB- GLP-1 -RRB- - -LRB- 7-36 -RRB- amide in type 2 -LRB- noninsulin-dependent -RRB- diabetic patients .
8650968	0	glucose	126,133	GLP-1	36,41	glucose	GLP-1	MESH:D005947	100125288	Chemical	Gene	Release|nmod|START_ENTITY Release|nmod|glucagon-like_peptide_1 glucagon-like_peptide_1|appos|-RSB- -RSB-|compound|END_ENTITY	Release of glucagon-like_peptide_1 -LRB- GLP-1 -LSB- 7-36 amide -RSB- -RRB- , gastric inhibitory polypeptide -LRB- GIP -RRB- and insulin in response to oral glucose after upper and lower intestinal resections .
8902200	2	glucose	344,351	GLP-1	478,483	glucose	GLP-1	MESH:D005947	24952(Tax:10116)	Chemical	Gene	absence|nmod|START_ENTITY allows|nmod|absence allows|dobj|expression expression|nmod|potential potential|nmod|END_ENTITY	This report shows that , in the absence of glucose , a nonglucidic nutrient , namely succinic_acid_dimethyl_ester -LRB- SAD -RRB- , allows full expression of the insulinotropic potential of GLP-1 in the perfused pancreas from diabetic GK rats .
9049482	0	glucose	30,37	GLP-1	110,115	glucose	GLP-1	MESH:D005947	2641	Chemical	Gene	concentrations|compound|START_ENTITY Near-normalisation|nmod|concentrations Near-normalisation|appos|END_ENTITY	Near-normalisation of diurnal glucose concentrations by continuous administration of glucagon-like_peptide-1 -LRB- GLP-1 -RRB- in subjects with NIDDM .
9568697	0	glucose	72,79	GLP-1	43,48	glucose	GLP-1	MESH:D005947	14526(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY essential|nmod|homeostasis essential|nsubj|actions actions|appos|END_ENTITY	Identification of glucagon-like peptide 1 -LRB- GLP-1 -RRB- actions essential for glucose homeostasis in mice with disruption of GLP-1_receptor signaling .
9568806	2	glucose	425,432	GLP-1	378,383	glucose	GLP-1	MESH:D005947	2641	Chemical	Gene	metabolism|compound|START_ENTITY effects|nmod|metabolism exerts|dobj|effects exerts|nsubj|END_ENTITY	To assess whether GLP-1 exerts also direct effects on whole-body glucose metabolism , 6,6-D2-glucose kinetics were measured in 8 healthy volunteers receiving once GLP-1 , once saline during hyperglycemic glucose clamping , while somatostatin with replacement amounts of insulin , glucagon and growth_hormone was infused .
9568806	2	glucose	562,569	GLP-1	378,383	glucose	GLP-1	MESH:D005947	2641	Chemical	Gene	clamping|compound|START_ENTITY receiving|nmod|clamping volunteers|acl|receiving measured|nmod|volunteers measured|advcl|assess assess|ccomp|exerts exerts|nsubj|END_ENTITY	To assess whether GLP-1 exerts also direct effects on whole-body glucose metabolism , 6,6-D2-glucose kinetics were measured in 8 healthy volunteers receiving once GLP-1 , once saline during hyperglycemic glucose clamping , while somatostatin with replacement amounts of insulin , glucagon and growth_hormone was infused .
25573030	0	glucose	61,68	GLP-1R	77,83	glucose	GLP-1R	MESH:D005947	2740	Chemical	Gene	induced|nmod|START_ENTITY induced|nmod|END_ENTITY	Liraglutide inhibits autophagy and apoptosis induced by high glucose through GLP-1R in renal tubular epithelial cells .
20487568	0	glucose	59,66	GLUT	80,84	glucose	GLUT	MESH:D005947	6513	Chemical	Gene	ancestry|nmod|START_ENTITY transporter|nsubj|ancestry transporter|dep|END_ENTITY	Evolutionary ancestry and novel functions of the mammalian glucose transporter -LRB- GLUT -RRB- family .
2566971	0	glucose	43,50	GLUT	64,68	glucose	GLUT	MESH:D005947	6513	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Stu I RFLP at the human Hep G2/erythrocyte glucose transporter -LRB- GLUT -RRB- gene locus .
26650681	0	glucose	72,79	GLUT	0,4	glucose	GLUT	MESH:D005947	6513	Chemical	Gene	transporters|compound|START_ENTITY investigations|nmod|transporters investigations|dep|END_ENTITY	GLUT , SGLT , and SWEET : Structural and mechanistic investigations of the glucose transporters .
10336852	0	glucose	50,57	GLUT-1	71,77	glucose	GLUT-1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY ischemia|nmod|expression Effect|nmod|ischemia transporters|nsubj|Effect transporters|dobj|END_ENTITY	Effect of transient ischemia on the expression of glucose transporters GLUT-1 and GLUT-4 in rat myocardium .
10364200	0	glucose	27,34	GLUT-1	20,26	glucose	GLUT-1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	transcription|compound|START_ENTITY transcription|compound|END_ENTITY	Factors involved in GLUT-1 glucose transporter gene transcription in cardiac muscle .
10424886	0	glucose	61,68	GLUT-1	82,88	glucose	GLUT-1	MESH:D005947	20525(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY study|nmod|transporter study|appos|END_ENTITY	Quantitative immunocytochemical study of blood-brain barrier glucose transporter -LRB- GLUT-1 -RRB- in four regions of mouse brain .
10908851	0	glucose	22,29	GLUT-1	6,12	glucose	GLUT-1	MESH:D005947	6513	Chemical	Gene	transport|compound|START_ENTITY mediated|dobj|transport mediated|nsubj|END_ENTITY	Rapid GLUT-1 mediated glucose transport in erythrocytes from the grey-headed fruit bat -LRB- Pteropus poliocephalus -RRB- .
10927023	0	glucose	14,21	GLUT-1	102,108	glucose	GLUT-1	MESH:D005947	6513	Chemical	Gene	START_ENTITY|dobj|interactions interactions|appos|END_ENTITY	Inhibition of glucose transport and direct interactions with type 1 facilitative glucose transporter -LRB- GLUT-1 -RRB- by etomidate , ketamine , and propofol : a comparison with barbiturates .
10927023	0	glucose	81,88	GLUT-1	102,108	glucose	GLUT-1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY interactions|nmod|transporter interactions|appos|END_ENTITY	Inhibition of glucose transport and direct interactions with type 1 facilitative glucose transporter -LRB- GLUT-1 -RRB- by etomidate , ketamine , and propofol : a comparison with barbiturates .
11006027	0	glucose	21,28	GLUT-1	14,20	glucose	GLUT-1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Expression of GLUT-1 glucose transporter in borderline and malignant_epithelial_tumors of the ovary .
11249857	0	glucose	47,54	GLUT-1	10,16	glucose	GLUT-1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	induction|compound|START_ENTITY protects|nmod|induction protects|nsubj|END_ENTITY	Antisense GLUT-1 protects mesangial cells from glucose induction of GLUT-1 and fibronectin expression .
11249857	0	glucose	47,54	GLUT-1	68,74	glucose	GLUT-1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	induction|compound|START_ENTITY induction|nmod|expression expression|compound|END_ENTITY	Antisense GLUT-1 protects mesangial cells from glucose induction of GLUT-1 and fibronectin expression .
11287341	0	glucose	44,51	GLUT-1	37,43	glucose	GLUT-1	MESH:D005947	6513	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Overexpression of stomatin depresses GLUT-1 glucose transporter activity .
11477169	0	glucose	119,126	GLUT-1	86,92	glucose	GLUT-1	MESH:D005947	6513	Chemical	Gene	metabolism|compound|START_ENTITY regulating|dobj|metabolism associated|xcomp|regulating associated|nmod|polymorphisms polymorphisms|nmod|genes genes|compound|END_ENTITY	Diabetic_microvascular_complications are not associated with two polymorphisms in the GLUT-1 and PC-1 genes regulating glucose metabolism in Caucasian type 1 diabetic patients .
11546675	0	glucose	22,29	GLUT-1	15,21	glucose	GLUT-1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Stimulation Stimulation|nmod|END_ENTITY	Stimulation of GLUT-1 glucose transporter expression in response to hyperosmolarity .
12734805	0	glucose	90,97	GLUT-1	132,138	glucose	GLUT-1	MESH:D005947	6513	Chemical	Gene	moiety|compound|START_ENTITY reducing|dobj|moiety containing|advcl|reducing glycopolymer|acl|containing interaction|nmod|glycopolymer Visualization|nmod|interaction mediated|nsubj|Visualization mediated|nmod|END_ENTITY	Visualization of specific interaction between biomimetic glycopolymer containing reducing glucose moiety and HepG2 cell mediated by GLUT-1 .
1314824	0	glucose	36,43	GLUT-1	57,63	glucose	GLUT-1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Tumor_necrosis_factor_alpha-induced glucose transporter -LRB- GLUT-1 -RRB- mRNA stabilization in 3T3-L1 preadipocytes .
14499345	0	glucose	61,68	GLUT-1	91,97	glucose	GLUT-1	MESH:D005947	6513	Chemical	Gene	transport|compound|START_ENTITY transport|acl|mediated mediated|nmod|END_ENTITY	Sphingomyelin/cholesterol ratio : an important determinant of glucose transport mediated by GLUT-1 in 3T3-L1 preadipocytes .
14499345	1	glucose	354,361	GLUT-1	287,293	glucose	GLUT-1	MESH:D005947	6513	Chemical	Gene	responsible|nmod|START_ENTITY transport|amod|responsible transporter|dep|transport transporter|compound|END_ENTITY	Sphingomyelin pathway has been linked with insulin signaling through insulin-dependent GLUT-4 glucose transporter , but a relationship between sphingomyelin and the GLUT-1 transporter responsible for the basal -LRB- insulin-independent -RRB- glucose transport has not been clearly established .
14613256	0	glucose	47,54	GLUT-1	111,117	glucose	GLUT-1	MESH:D005947	20512(Tax:10090)	Chemical	Gene	interactions|nmod|START_ENTITY Determination|nmod|interactions ligand|nsubj|Determination ligand|xcomp|carrying carrying|dep|END_ENTITY	Determination of specific interactions between glucose ligand carrying polymer and glucose_transporter_type-1 -LRB- GLUT-1 -RRB- using different cell types .
15027127	0	glucose	21,28	GLUT-1	14,20	glucose	GLUT-1	MESH:D005947	6513	Chemical	Gene	transfer|compound|START_ENTITY transfer|compound|END_ENTITY	Expression of GLUT-1 glucose transfer , cellular proliferation activity and grade of tumor correlate with -LSB- F-18 -RSB- - fluorodeoxyglucose uptake by positron emission tomography in epithelial_tumors of the ovary .
15037634	0	glucose	131,138	GLUT-1	203,209	glucose	GLUT-1	MESH:D005947	6513	Chemical	Gene	transport|compound|START_ENTITY suppresses|dobj|transport suppresses|nmod|cells cells|nmod|END_ENTITY	Activation of syntaxin 1C , an alternative splice variant of HPC-1 / syntaxin_1A , by phorbol_12-myristate_13-acetate -LRB- PMA -RRB- suppresses glucose transport into astroglioma cells via the glucose_transporter-1 -LRB- GLUT-1 -RRB- .
1512261	0	glucose	45,52	GLUT-1	27,33	glucose	GLUT-1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	Expression and function of GLUT-1 and GLUT-2 glucose transporter isoforms in cells of cultured rat pancreatic islets .
1552163	0	glucose	7,14	GLUT-1	0,6	glucose	GLUT-1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	GLUT-1 glucose transporter is present within apical and basolateral membranes of brain epithelial interfaces and in microvascular endothelia with and without tight junctions .
18172662	0	glucose	14,21	GLUT-1	35,41	glucose	GLUT-1	MESH:D005947	6513	Chemical	Gene	Expression|nmod|START_ENTITY transporters|nsubj|Expression transporters|xcomp|END_ENTITY	Expression of glucose transporters GLUT-1 , GLUT-3 , GLUT-9 and HIF-1alpha in normal and degenerate human intervertebral disc .
18196278	0	glucose	149,156	GLUT-1	60,66	glucose	GLUT-1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	pathway|compound|START_ENTITY contribution|nmod|pathway localization|dep|contribution localization|nmod|END_ENTITY	Cellular localization of facilitated glucose transporter 1 -LRB- GLUT-1 -RRB- in the cochlear stria vascularis : its possible contribution to the transcellular glucose pathway .
18953257	0	glucose	29,36	GLUT-1	22,28	glucose	GLUT-1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Apigenin inhibits the GLUT-1 glucose transporter and the phosphoinositide_3-kinase / Akt pathway in human pancreatic_cancer cells .
1915077	0	glucose	32,39	GLUT-1	25,31	glucose	GLUT-1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Expression of the low Km GLUT-1 glucose transporter is turned on in perivenous hepatocytes of insulin-deficient diabetic rats .
1990010	0	glucose	49,56	GLUT-1	31,37	glucose	GLUT-1	MESH:D005947	6513	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|END_ENTITY	Differential regulation of the GLUT-1 and GLUT-4 glucose transport systems by glucose and insulin in L6 muscle cells in culture .
1990010	0	glucose	78,85	GLUT-1	31,37	glucose	GLUT-1	MESH:D005947	6513	Chemical	Gene	glucose|nmod|START_ENTITY glucose|nsubj|regulation regulation|nmod|END_ENTITY	Differential regulation of the GLUT-1 and GLUT-4 glucose transport systems by glucose and insulin in L6 muscle cells in culture .
21910135	0	glucose	7,14	GLUT-1	0,6	glucose	GLUT-1	MESH:D005947	6513	Chemical	Gene	transporters|compound|START_ENTITY transporters|compound|END_ENTITY	GLUT-1 glucose transporters in the blood-brain barrier : differential phosphorylation .
7491913	0	glucose	22,29	GLUT-1	15,21	glucose	GLUT-1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Stimulation Stimulation|nmod|END_ENTITY	Stimulation of GLUT-1 glucose transporter expression in response to exposure to calcium ionophore A-23187 .
7762644	0	glucose	23,30	GLUT-1	49,55	glucose	GLUT-1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|nsubj|transport	Growth_hormone reduces glucose transport but not GLUT-1 or GLUT-4 in adult and old rats .
7771180	0	glucose	7,14	GLUT-1	0,6	glucose	GLUT-1	MESH:D005947	20525(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	GLUT-1 glucose transporter is localized heterogeneously within the microvessels of the mouse hippocampus .
7884040	0	glucose	57,64	GLUT-1	78,84	glucose	GLUT-1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY expression|nmod|transporter expression|appos|END_ENTITY	Immunocytochemical expression of the blood-brain barrier glucose transporter -LRB- GLUT-1 -RRB- in neural_transplants_and_brain_wounds .
8216241	0	glucose	107,114	GLUT-1	97,103	glucose	GLUT-1	MESH:D005947	20525(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY surface|nmod|metabolism surface|dobj|expression expression|nmod|END_ENTITY	Differential control of the functional cell surface expression and content of hexose transporter GLUT-1 by glucose and glucose metabolism in murine fibroblasts .
8325875	0	glucose	18,25	GLUT-1	11,17	glucose	GLUT-1	MESH:D005947	100125988(Tax:9986)	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	GLUT-4 and GLUT-1 glucose transporter expression is differentially regulated by contractile activity in skeletal muscle .
8349608	0	glucose	27,34	GLUT-1	20,26	glucose	GLUT-1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Rapid activation of GLUT-1 glucose transporter following inhibition of oxidative phosphorylation in clone 9 cells .
8453764	0	glucose	37,44	GLUT-1	58,64	glucose	GLUT-1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY Ontogeny|nmod|transporter Ontogeny|appos|END_ENTITY	Ontogeny of the erythroid/HepG2-type glucose transporter -LRB- GLUT-1 -RRB- in the rat nervous system .
8589651	0	glucose	27,34	GLUT-1	70,76	glucose	GLUT-1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY transport|appos|END_ENTITY	Differential regulation of glucose transport and glucose transporter -LRB- GLUT-1 -RRB- gene expression by vanadate , phorbol_ester and okadaic_acid in L6 skeletal muscle cells .
8761487	0	glucose	14,21	GLUT-1	36,42	glucose	GLUT-1	MESH:D005947	6513	Chemical	Gene	transporters|compound|START_ENTITY Regulation|nmod|transporters Regulation|dep|END_ENTITY	Regulation of glucose transporters -LRB- GLUT-1 and GLUT-3 -RRB- in human retinal endothelial cells .
8972727	0	glucose	15,22	GLUT-1	90,96	glucose	GLUT-1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY Stimulation|nmod|transport Stimulation|dep|role role|nmod|activation activation|compound|END_ENTITY	Stimulation of glucose transport in Clone 9 cells by insulin and thyroid hormone : role of GLUT-1 activation .
9008459	0	glucose	75,82	GLUT-1	68,74	glucose	GLUT-1	MESH:D005947	6513	Chemical	Gene	transporters|compound|START_ENTITY transporters|compound|END_ENTITY	Low-flow ischemia leads to translocation of canine heart GLUT-4 and GLUT-1 glucose transporters to the sarcolemma in vivo .
9354367	0	glucose	96,103	GLUT-1	117,123	glucose	GLUT-1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Specific interaction between erythrocytes and a glucose-carrying polymer mediated by the type-1 glucose transporter -LRB- GLUT-1 -RRB- on the cell membrane .
9429298	0	glucose	37,44	GLUT-1	59,65	glucose	GLUT-1	MESH:D005947	6513	Chemical	Gene	transporters|compound|START_ENTITY transporters|appos|END_ENTITY	Immobilization of active facilitated glucose transporters -LRB- GLUT-1 -RRB- in supported biological membranes .
9458906	0	glucose	26,33	GLUT-1	0,6	glucose	GLUT-1	MESH:D005947	6513	Chemical	Gene	transport|compound|START_ENTITY mediation|nmod|transport mediation|compound|END_ENTITY	GLUT-1 mediation of rapid glucose transport in dolphin -LRB- Tursiops_truncatus -RRB- red blood cells .
9776278	0	glucose	19,26	GLUT-1	12,18	glucose	GLUT-1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|dep|transporter	FDG uptake , GLUT-1 glucose transporter and cellularity in human pancreatic_tumors .
9950801	0	glucose	50,57	GLUT-1	0,6	glucose	GLUT-1	MESH:D005947	20525(Tax:10090)	Chemical	Gene	tolerance|compound|START_ENTITY improve|dobj|tolerance improve|nsubj|transgenes transgenes|amod|END_ENTITY	GLUT-1 or GLUT-4 transgenes in obese mice improve glucose tolerance but do not prevent insulin resistance .
11512021	0	glucose	57,64	GLUT-2	88,94	glucose	GLUT-2	MESH:D005947	282357(Tax:9913)	Chemical	Gene	isoform-2|compound|START_ENTITY isoform-2|appos|END_ENTITY	Effects of triiodothyronine and bovine growth hormone on glucose transporter isoform-2 -LRB- GLUT-2 -RRB- and glucokinase -LRB- GK -RRB- gene expression in pancreatic islets of fetal and adult rats .
1420258	0	glucose	62,69	GLUT-2	14,20	glucose	GLUT-2	MESH:D005947	6514	Chemical	Gene	transport|compound|START_ENTITY analysis|nmod|transport Expression|dep|analysis Expression|nmod|cDNA cDNA|compound|END_ENTITY	Expression of GLUT-2 cDNA in human B lymphocytes : analysis of glucose transport using flow cytometry .
15662550	0	glucose	20,27	GLUT-2	92,98	glucose	GLUT-2	MESH:D005947	25351(Tax:10116)	Chemical	Gene	transporters|compound|START_ENTITY Characterisation|nmod|transporters Characterisation|dep|END_ENTITY	Characterisation of glucose transporters in the intact coronary artery endothelium in rats : GLUT-2 upregulated by long-term hyperglycaemia .
26490765	1	glucose	75,82	GLUT-2	99,105	glucose	GLUT-2	MESH:D005947	25351(Tax:10116)	Chemical	Gene	gene|compound|START_ENTITY effect|nmod|gene effect|dep|END_ENTITY	and its effect on the glucose transport gene -LRB- GLUT-2 and GLUT-4 -RRB- in streptozotocin induced diabetic wistar_rats .
8279547	0	glucose	18,25	GLUT-2	11,17	glucose	GLUT-2	MESH:D005947	6514	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	High Km of GLUT-2 glucose transporter does not explain its role in insulin secretion .
8433987	0	glucose	29,36	GLUT-2	22,28	glucose	GLUT-2	MESH:D005947	6514	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Autoantibodies to the GLUT-2 glucose transporter of beta cells in insulin-dependent_diabetes_mellitus of recent onset .
10329982	0	glucose	21,28	GLUT-3	14,20	glucose	GLUT-3	MESH:D005947	25551(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Regulation of GLUT-3 glucose transporter in the hippocampus of diabetic rats subjected to stress .
11080093	0	glucose	66,73	GLUT-3	59,65	glucose	GLUT-3	MESH:D005947	6515	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|END_ENTITY	Time-dependent physiological regulation of ovine placental GLUT-3 glucose transporter protein .
17497451	11	glucose	1148,1155	GLUT-3	1212,1218	glucose	GLUT-3	MESH:D005947	6515	Chemical	Gene	concentration|compound|START_ENTITY affect|nsubj|concentration affect|dobj|expression expression|nmod|END_ENTITY	High glucose concentration did not affect cell surface expression of GLUT-3 and GLUT-4 .
24229026	2	glucose	585,592	GLUT-3	624,630	glucose	GLUT-1	MESH:D005947	6513	Chemical	Gene	transporter-1|compound|START_ENTITY mediated|nmod|transporter-1 mediated|nmod|END_ENTITY	It is known that the most important pathway for -LRB- 18 -RRB- F-FDG to enter the cell body is mediated by the facilitative glucose transporter-1 -LRB- GLUT-1 -RRB- through GLUT-3 .
9230074	0	glucose	20,27	GLUT-3	106,112	glucose	GLUT-3	MESH:D005947	6515	Chemical	Gene	transport|compound|START_ENTITY transport|nmod|platelets platelets|nmod|translocation translocation|nmod|END_ENTITY	Thrombin stimulates glucose transport in human platelets via the translocation of the glucose_transporter GLUT-3 from alpha-granules to the cell surface .
10778531	0	glucose	86,93	GLUT-4	0,6	glucose	GLUT-4	MESH:D005947	6517	Chemical	Gene	homeostasis|compound|START_ENTITY necrosis|nmod|homeostasis necrosis|ccomp|END_ENTITY	GLUT-4 , tumour necrosis factor , essential fatty_acids and daf-genes and their role in glucose homeostasis , insulin resistance , non-insulin_dependent_diabetes_mellitus , and longevity .
11093924	0	glucose	19,26	GLUT-4	55,61	glucose	GLUT-4	MESH:D005947	6517	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|END_ENTITY	Ethanol stimulates glucose uptake and translocation of GLUT-4 in H9c2 myotubes via a Ca -LRB- 2 + -RRB- - dependent mechanism .
11171596	0	glucose	72,79	GLUT-4	65,71	glucose	GLUT-4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Glucose metabolism in perfused mouse hearts overexpressing human GLUT-4 glucose transporter .
11406496	0	glucose	38,45	GLUT-4	71,77	glucose	GLUT-4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	hearts|nmod|START_ENTITY Protection|nmod|hearts mediated|nsubjpass|Protection mediated|nmod|END_ENTITY	Protection of ischemic hearts by high glucose is mediated , in part , by GLUT-4 .
15015152	0	glucose	30,37	GLUT-4	23,29	glucose	GLUT-4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Insulin resistance and GLUT-4 glucose transporter in adipocytes from hypertensive rats .
1547918	0	glucose	167,174	GLUT-4	188,194	glucose	GLUT-4	MESH:D005947	6517	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Insulin resistance in type 2 -LRB- non-insulin-dependent -RRB- diabetic patients and their relatives is not associated with a defect in the expression of the insulin-responsive glucose transporter -LRB- GLUT-4 -RRB- gene in human skeletal muscle .
1577853	0	glucose	69,76	GLUT-4	90,96	glucose	GLUT-4	MESH:D005947	6517	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	The efficient intracellular sequestration of the insulin-regulatable glucose transporter -LRB- GLUT-4 -RRB- is conferred by the NH2 terminus .
15810997	0	glucose	49,56	GLUT-4	7,13	glucose	GLUT-4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY study|dobj|uptake null|xcomp|study null|nsubj|Use Use|nmod|END_ENTITY	Use of GLUT-4 null mice to study skeletal muscle glucose uptake .
1625680	0	glucose	43,50	GLUT-4	36,42	glucose	GLUT-4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Vanadate induces the recruitment of GLUT-4 glucose transporter to the plasma membrane of rat adipocytes .
16615095	0	glucose	35,42	GLUT-4	56,62	glucose	GLUT-4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	TCDD suppresses insulin-responsive glucose transporter -LRB- GLUT-4 -RRB- gene expression through C/EBP nuclear transcription factors in 3T3-L1 adipocytes .
23837585	0	glucose	60,67	GLUT-4	15,21	glucose	GLUT-4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY rutin|nmod|uptake effect|nmod|rutin END_ENTITY|nmod|effect	Involvement of GLUT-4 in the stimulatory effect of rutin on glucose uptake in rat soleus muscle .
24303141	0	glucose	24,31	GLUT-4	76,82	glucose	GLUT-4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	uptake|nsubj|START_ENTITY uptake|nmod|mice mice|nmod|deletion deletion|compound|END_ENTITY	Exercise-induced muscle glucose uptake in mice with graded , muscle-specific GLUT-4 deletion .
26993529	0	glucose	36,43	GLUT-4	91,97	glucose	GLUT-4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	consumption|compound|START_ENTITY increased|dobj|consumption increased|advcl|up-regulating up-regulating|dobj|expression expression|nmod|END_ENTITY	Schisandra polysaccharide increased glucose consumption by up-regulating the expression of GLUT-4 .
7491256	0	glucose	54,61	GLUT-4	75,81	glucose	GLUT-4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Ca -LRB- 2 + -RRB- - and GTP -LSB- gamma S -RSB- - induced translocation of the glucose transporter , GLUT-4 , to the plasma membrane of permeabilized cardiomyocytes determined using a novel immunoprecipitation method .
7733259	0	glucose	40,47	GLUT-4	33,39	glucose	GLUT-4	MESH:D005947	6517	Chemical	Gene	transporters|compound|START_ENTITY transporters|compound|END_ENTITY	Insulin induces translocation of GLUT-4 glucose transporters in human skeletal muscle .
7762651	0	glucose	49,56	GLUT-4	11,17	glucose	GLUT-4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY overexpression|nmod|metabolism overexpression|compound|END_ENTITY	Transgenic GLUT-4 overexpression in fat enhances glucose metabolism : preferential effect on fatty_acid synthesis .
7868815	0	glucose	42,49	GLUT-4	68,74	glucose	GLUT-4	MESH:D005947	6517	Chemical	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	Decreased expression of insulin-sensitive glucose transporter mRNA -LRB- GLUT-4 -RRB- in adipose tissue of non-insulin-dependent diabetic_and_obese patients : evaluation by a simplified quantitative PCR assay .
8031552	0	glucose	55,62	GLUT-4	121,127	glucose	GLUT-4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY modulation|nmod|transport modulation|dep|implication implication|nmod|END_ENTITY	Insulin_and_insulin-like_growth_factor-1 modulation of glucose transport in arterial smooth muscle cells : implication of GLUT-4 in the vasculature .
8315221	0	glucose	18,25	GLUT-4	11,17	glucose	GLUT-4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Myocardial GLUT-4 glucose transporter protein levels of rats decline with advancing age .
8333514	0	glucose	24,31	GLUT-4	44,50	glucose	GLUT-4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY transporter|nsubj|expression transporter|dobj|END_ENTITY	Increased expression of glucose transporter GLUT-4 in brown adipose tissue of fasted rats after cold exposure .
8430763	0	glucose	61,68	GLUT-4	54,60	glucose	GLUT-4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Adaptation of muscle to creatine depletion : effect on GLUT-4 glucose transporter expression .
8447386	0	glucose	80,87	GLUT-4	73,79	glucose	GLUT-4	MESH:D005947	6517	Chemical	Gene	transporters|compound|START_ENTITY transporters|compound|END_ENTITY	Insulin resistance in polycystic_ovary_syndrome : decreased expression of GLUT-4 glucose transporters in adipocytes .
8447397	0	glucose	21,28	GLUT-4	14,20	glucose	GLUT-4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Expression of GLUT-4 glucose transporter in unweighted soleus muscle of normal and STZ-induced diabetic rats .
8514693	0	glucose	24,31	GLUT-4	51,57	glucose	GLUT-4	MESH:D005947	6517	Chemical	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	Exercise reduces muscle glucose transport protein -LRB- GLUT-4 -RRB- mRNA in type 1 diabetic patients .
8612543	0	glucose	98,105	GLUT-4	91,97	glucose	GLUT-4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Normalization of insulin secretion by a selective alpha 2-adrenoceptor antagonist restores GLUT-4 glucose transporter expression in adipose tissue of type II diabetic rats .
9124341	0	glucose	32,39	GLUT-4	67,73	glucose	GLUT-4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY training|nmod|transport Effects|nmod|training surface|nsubj|Effects surface|dobj|muscle muscle|amod|END_ENTITY	Effects of exercise training on glucose transport and cell surface GLUT-4 in isolated rat epitrochlearis muscle .
9572814	0	glucose	14,21	GLUT-4	35,41	glucose	GLUT-4	MESH:D005947	6517	Chemical	Gene	Regulation|nmod|START_ENTITY transporters|nsubj|Regulation transporters|dobj|transcription transcription|amod|END_ENTITY	Regulation of glucose transporters GLUT-4 and GLUT-1 gene transcription in denervated skeletal muscle .
9655766	0	glucose	94,101	GLUT-4	77,83	glucose	GLUT-4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|nmod|transport	Glycogen supercompensation masks the effect of a traininginduced increase in GLUT-4 on muscle glucose transport .
9760308	0	glucose	79,86	GLUT-4	10,16	glucose	GLUT-4	MESH:D005947	6517	Chemical	Gene	transport|compound|START_ENTITY sensitivity|nmod|transport enhanced|dobj|sensitivity enhanced|nsubj|mediates mediates|compound|END_ENTITY	Increased GLUT-4 translocation mediates enhanced insulin sensitivity of muscle glucose transport after exercise .
10022440	0	glucose	73,80	GLUT1	67,72	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Diabetes alters the expression and activity of the human placental GLUT1 glucose transporter .
10085148	0	glucose	34,41	GLUT1	54,59	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY activation|nmod|transporter END_ENTITY|nsubj|activation	Transcriptional activation of the glucose transporter GLUT1 in ventricular cardiac myocytes by hypertrophic agonists .
10198040	0	glucose	30,37	GLUT1	103,108	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	protein|compound|START_ENTITY interactions|nmod|protein GLUT1CBP|nsubj|interactions GLUT1CBP|ccomp|provide provide|dobj|link link|nmod|END_ENTITY	Protein interactions with the glucose transporter binding protein GLUT1CBP that provide a link between GLUT1 and the cytoskeleton .
10551878	0	glucose	50,57	GLUT1	34,39	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	START_ENTITY|nsubj|control control|nmod|END_ENTITY	Opposite translational control of GLUT1 and GLUT4 glucose transporter mRNAs in response to insulin .
10556032	0	glucose	6,13	GLUT1	0,5	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transcription|compound|START_ENTITY transcription|compound|END_ENTITY	GLUT1 glucose transporter gene transcription is repressed by Sp3 .
10586946	0	glucose	40,47	GLUT1	61,66	glucose	GLUT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY transporters|nsubj|expression transporters|dobj|END_ENTITY	Differential expression of facilitative glucose transporters GLUT1 and GLUT3 in the lens .
10657854	0	glucose	113,120	GLUT1	97,102	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	proteins|compound|START_ENTITY proteins|compound|END_ENTITY	Stimulation of glucose transport by thyroid hormone in 3T3-L1 adipocytes : increased abundance of GLUT1 and GLUT4 glucose transporter proteins .
10657854	0	glucose	15,22	GLUT1	97,102	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transport|compound|START_ENTITY Stimulation|nmod|transport Stimulation|dep|abundance abundance|nmod|proteins proteins|compound|END_ENTITY	Stimulation of glucose transport by thyroid hormone in 3T3-L1 adipocytes : increased abundance of GLUT1 and GLUT4 glucose transporter proteins .
10666003	0	glucose	24,31	GLUT1	18,23	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	START_ENTITY|nsubj|inhibition inhibition|nmod|END_ENTITY	The inhibition of GLUT1 glucose transport and cytochalasin B binding activity by tricyclic antidepressants .
10759149	0	glucose	29,36	GLUT1	23,28	glucose	GLUT1	MESH:D005947	20512(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Golgi targeting of the GLUT1 glucose transporter in lactating mouse mammary gland .
10924131	0	glucose	84,91	GLUT1	65,70	glucose	GLUT1	MESH:D005947	494763(Tax:8355)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Cysteine-scanning mutagenesis of transmembrane segment 11 of the GLUT1 facilitative glucose transporter .
10961437	0	glucose	63,70	GLUT1	57,62	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|dobj|transporter	Post-transcription modulation of the blood-brain barrier GLUT1 glucose transporter by brain-derived factors .
11020555	0	glucose	52,59	GLUT1	72,77	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY cytochemistry|nmod|transporter END_ENTITY|nsubj|cytochemistry	Immunogold cytochemistry of the blood-brain barrier glucose transporter GLUT1 and endogenous albumin in the developing human brain .
11082199	0	glucose	72,79	GLUT1	66,71	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Conversion between two cytochalasin_B-binding states of the human GLUT1 glucose transporter .
11124961	0	glucose	28,35	GLUT1	78,83	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	uptake|compound|START_ENTITY stimulates|dobj|uptake stimulates|advcl|increasing increasing|dobj|levels levels|compound|END_ENTITY	Arachidonic_acid stimulates glucose uptake in 3T3-L1 adipocytes by increasing GLUT1 and GLUT4 levels at the plasma membrane .
11319835	0	glucose	26,33	GLUT1	20,25	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Localization of the GLUT1 glucose transporter to brefeldin_A-sensitive vesicles of differentiated CIT3 mouse mammary epithelial cells .
11463479	0	glucose	43,50	GLUT1	37,42	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	expression|compound|START_ENTITY END_ENTITY|dobj|expression	Amplification of blood-brain barrier GLUT1 glucose transporter gene expression by brain-derived peptides .
11485019	0	glucose	56,63	GLUT1	81,86	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	gene|compound|START_ENTITY analysis|nmod|gene END_ENTITY|nsubj|analysis	Single-strand conformation polymorphism analysis of the glucose transporter gene GLUT1 in maturity-onset diabetes_of_the_young .
11779583	0	glucose	77,84	GLUT1	35,40	glucose	GLUT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	function|compound|START_ENTITY changing|dobj|function END_ENTITY|advcl|changing	Chronic acarbose-feeding increases GLUT1 protein without changing intestinal glucose absorption function .
11906001	0	glucose	69,76	GLUT1	63,68	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Glucose_deprivation and hypoxia increase the expression of the GLUT1 glucose transporter via a specific mRNA cis-acting regulatory element .
11991658	0	glucose	56,63	GLUT1	86,91	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	isoforms|compound|START_ENTITY isoforms|dep|END_ENTITY	Human articular chondrocytes express three facilitative glucose transporter isoforms : GLUT1 , GLUT3 and GLUT9 .
12029447	0	glucose	12,19	GLUT1	48,53	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	deficiency_syndrome|compound|START_ENTITY deficiency_syndrome|compound|END_ENTITY	Facilitated glucose transporter protein type 1 -LRB- GLUT1 -RRB- deficiency_syndrome : impaired glucose transport into brain -- a review .
12029447	0	glucose	85,92	GLUT1	48,53	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transport|compound|START_ENTITY deficiency_syndrome|dep|transport deficiency_syndrome|compound|END_ENTITY	Facilitated glucose transporter protein type 1 -LRB- GLUT1 -RRB- deficiency_syndrome : impaired glucose transport into brain -- a review .
12133004	0	glucose	132,139	GLUT1	153,158	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Interactions of ATP , oestradiol , genistein and the anti-oestrogens , faslodex -LRB- ICI_182780 -RRB- and tamoxifen , with the human erythrocyte glucose transporter , GLUT1 .
12143238	0	glucose	24,31	GLUT1	18,23	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Expression of the GLUT1 glucose transporter in gallbladder_carcinomas .
12488050	0	glucose	29,36	GLUT1	108,113	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	isoforms|compound|START_ENTITY localization|nmod|isoforms localization|dep|distribution distribution|nmod|END_ENTITY	Differential localization of glucose transporter isoforms in non-polarized mammalian cells : distribution of GLUT1 but not GLUT3 to detergent-resistant membrane domains .
12548383	0	glucose	45,52	GLUT1	66,71	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transport|compound|START_ENTITY transport|nmod|END_ENTITY	Effects of anticonvulsants on GLUT1-mediated glucose transport in GLUT1 deficiency_syndrome in vitro .
12661915	0	glucose	14,21	GLUT1	35,40	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Regulation of glucose transporter -LRB- GLUT1 -RRB- gene expression by angiotensin_II in mesangial cells : involvement of HB-EGF_and_EGF_receptor transactivation .
12824265	2	glucose	272,279	GLUT1	321,326	glucose	GLUT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	concentrations|compound|START_ENTITY exposure|nmod|concentrations END_ENTITY|nsubj|exposure	In many cell types , exposure to high glucose concentrations or diabetes downregulates GLUT1 .
12849991	0	glucose	68,75	GLUT1	39,44	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transport|compound|START_ENTITY inhibits|dobj|transport inhibits|nsubj|reduction reduction|nmod|END_ENTITY	RNA interference-mediated reduction in GLUT1 inhibits serum-induced glucose transport in primary human skeletal muscle cells .
12882795	0	glucose	24,31	GLUT1	45,50	glucose	GLUT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	patterns|nmod|START_ENTITY transporters|nsubj|patterns transporters|dobj|END_ENTITY	Expression patterns for glucose transporters GLUT1 and GLUT3 in the normal rat lens and in models of diabetic_cataract .
1319316	0	glucose	31,38	GLUT1	52,57	glucose	GLUT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	The regulation of two distinct glucose transporter -LRB- GLUT1 and GLUT4 -RRB- gene expressions in cultured rat thyroid cells by thyrotropin .
1370154	0	glucose	111,118	GLUT1	14,19	glucose	GLUT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	glucose|nmod|START_ENTITY glucose|nsubj|Expression Expression|nmod|END_ENTITY	Expression of GLUT1 and GLUT2 glucose transporter isoforms in rat islets of Langerhans and their regulation by glucose .
1370154	0	glucose	30,37	GLUT1	14,19	glucose	GLUT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of GLUT1 and GLUT2 glucose transporter isoforms in rat islets of Langerhans and their regulation by glucose .
1417871	0	glucose	36,43	GLUT1	64,69	glucose	GLUT1	MESH:D005947	20525(Tax:10090)	Chemical	Gene	protein|compound|START_ENTITY function|nmod|protein END_ENTITY|nsubj|function	Expression and possible function of glucose transporter protein GLUT1 during preimplantation mouse development from oocytes to blastocysts .
1429604	0	glucose	56,63	GLUT1	50,55	glucose	GLUT1	MESH:D005947	100753506	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Replacement of intracellular C-terminal domain of GLUT1 glucose transporter with that of GLUT2 increases Vmax and Km of transport activity .
14643928	0	glucose	46,53	GLUT1	66,71	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|nsubj|transporter	On the oligomeric state of the red blood cell glucose transporter GLUT1 .
14688257	0	glucose	49,56	GLUT1	43,48	glucose	GLUT1	MESH:D005947	494763(Tax:8355)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Analysis of transmembrane segment 8 of the GLUT1 glucose transporter by cysteine-scanning mutagenesis and substituted cysteine accessibility .
14693696	0	glucose	34,41	GLUT1	92,97	glucose	GLUT1	MESH:D005947	20525(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY stimulates|dobj|uptake stimulates|advcl|inducing inducing|dobj|translocation translocation|compound|END_ENTITY	Dehydroepiandrosterone stimulates glucose uptake in human and murine adipocytes by inducing GLUT1 and GLUT4 translocation to the plasma membrane .
14709331	0	glucose	32,39	GLUT1	88,93	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transport|compound|START_ENTITY increases|dobj|transport increases|nmod|expression expression|compound|END_ENTITY	Prostaglandin_F2alpha increases glucose transport in 3T3-L1 adipocytes through enhanced GLUT1 expression by a protein_kinase_C-dependent pathway .
15058574	0	glucose	52,59	GLUT1	46,51	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Ethanol weakens cytochalasin_B binding to the GLUT1 glucose transporter and drug partitioning into lipid bilayers .
15059920	0	glucose	40,47	GLUT1	61,66	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	p53|dep|START_ENTITY transporters|nsubj|p53 transporters|dobj|expression expression|compound|END_ENTITY	The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression .
15073187	0	glucose	67,74	GLUT1	61,66	glucose	GLUT1	MESH:D005947	494763(Tax:8355)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Relative proximity and orientation of helices 4 and 8 of the GLUT1 glucose transporter .
15353351	0	glucose	56,63	GLUT1	34,39	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|appos|transporter	HTLV envelopes and their receptor GLUT1 , the ubiquitous glucose transporter : a new vision on HTLV_infection ?
1537878	0	glucose	29,36	GLUT1	134,139	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY expressed|nsubjpass|transporter expressed|parataxis|affects affects|dobj|levels levels|nummod|END_ENTITY	`` HepG2/erythroid/brain '' type glucose transporter -LRB- GLUT1 -RRB- is highly expressed in human epidermis : keratinocyte differentiation affects GLUT1 levels in reconstituted epidermis .
1537878	0	glucose	29,36	GLUT1	50,55	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	`` HepG2/erythroid/brain '' type glucose transporter -LRB- GLUT1 -RRB- is highly expressed in human epidermis : keratinocyte differentiation affects GLUT1 levels in reconstituted epidermis .
1544434	0	glucose	90,97	GLUT1	84,89	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Glucose binding enhances the papain susceptibility of the intracellular loop of the GLUT1 glucose transporter .
15579563	0	glucose	55,62	GLUT1	76,81	glucose	GLUT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Sequence and expression of a constitutive , facilitated glucose transporter -LRB- GLUT1 -RRB- in Atlantic_cod Gadus_morhua .
1569156	0	glucose	30,37	GLUT1	14,19	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transporters|compound|START_ENTITY transporters|compound|END_ENTITY	Expression of GLUT1 and GLUT4 glucose transporters in skeletal muscle of humans with insulin-dependent_diabetes_mellitus : regulatory effects of metabolic factors .
1571954	0	glucose	39,46	GLUT1	60,65	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY Localization|nmod|transporter Localization|appos|END_ENTITY	Localization of erythrocyte/HepG2-type glucose transporter -LRB- GLUT1 -RRB- in human placental villi .
15745834	0	glucose	54,61	GLUT1	75,80	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A novel polymorphism in the 5 ' flanking region of the glucose transporter -LRB- GLUT1 -RRB- gene is strongly associated with diabetic_nephropathy in patients with Type 1 diabetes_mellitus .
15859637	0	glucose	33,40	GLUT1	53,58	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY detection|nmod|transporter END_ENTITY|nsubj|detection	Immunohistochemical detection of glucose transporter GLUT1 in benign and malignant_fallopian_tube_epithelia , with comparison_to_ovarian_carcinomas .
1590751	0	glucose	54,61	GLUT1	75,80	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Characterization of functional human erythrocyte-type glucose transporter -LRB- GLUT1 -RRB- expressed in insect cells using a recombinant baculovirus .
15943951	0	glucose	47,54	GLUT1	18,23	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transporters|compound|START_ENTITY facilitative|dobj|transporters facilitative|nsubj|Expression Expression|nmod|END_ENTITY	Expression of the GLUT1 and GLUT9 facilitative glucose transporters in embryonic chondroblasts and mature chondrocytes in ovine articular cartilage .
16091581	0	glucose	54,61	GLUT1	75,80	glucose	GLUT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY transporters|nsubj|expression transporters|dobj|END_ENTITY	Renal expression and localization of the facilitative glucose transporters GLUT1 and GLUT12 in animal models of hypertension and diabetic_nephropathy .
16123445	0	glucose	76,83	GLUT1	107,112	glucose	GLUT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	flux|compound|START_ENTITY flux|nmod|expression expression|compound|END_ENTITY	Increased JNK phosphorylation and oxidative stress in response to increased glucose flux through increased GLUT1 expression in rat retinal endothelial cells .
16136514	0	glucose	44,51	GLUT1	65,70	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transporters|compound|START_ENTITY transporters|dep|END_ENTITY	Hypoxia inducible factor-1 and facilitative glucose transporters GLUT1 and GLUT3 : putative molecular components of the oxygen and glucose sensing apparatus in articular chondrocytes .
16189198	0	glucose	25,32	GLUT1	46,51	glucose	GLUT1	MESH:D005947	443461(Tax:9940)	Chemical	Gene	Regulation|nmod|START_ENTITY transporters|nsubj|Regulation transporters|dobj|END_ENTITY	Regulation of myocardial glucose transporters GLUT1 and GLUT4 in chronically anemic fetal lambs .
16366034	0	glucose	17,24	GLUT1	38,43	glucose	GLUT1	MESH:D005947	102174800	Chemical	Gene	Contents|nmod|START_ENTITY transporters|nsubj|Contents transporters|dobj|END_ENTITY	-LSB- Contents of the glucose transporters GLUT1 and GLUT4 in oxidative and glycolytic muscles of goat kids and adult goats -RSB- .
16516869	3	glucose	522,529	GLUT1	635,640	glucose	GLUT3	MESH:D005947	25551(Tax:10116)	Chemical	Gene	proteins|compound|START_ENTITY expression|nmod|proteins mediating|nsubj|expression explore|advcl|mediating studied|advcl|explore studied|ccomp|h h|nsubj|consequences consequences|nmod|seizures seizures|nmod|mRNAs mRNAs|compound|END_ENTITY	To explore the effects of such acute changes in metabolic demand on the expression of glucose transporter proteins mediating glucose delivery to brain , we studied the consequences of PTZ seizures on GLUT1 and GLUT3 mRNAs and proteins between 1 and 72 h after seizure induction .
16516869	3	glucose	561,568	GLUT1	635,640	glucose	GLUT3	MESH:D005947	25551(Tax:10116)	Chemical	Gene	delivery|compound|START_ENTITY mediating|dobj|delivery explore|advcl|mediating studied|advcl|explore studied|ccomp|h h|nsubj|consequences consequences|nmod|seizures seizures|nmod|mRNAs mRNAs|compound|END_ENTITY	To explore the effects of such acute changes in metabolic demand on the expression of glucose transporter proteins mediating glucose delivery to brain , we studied the consequences of PTZ seizures on GLUT1 and GLUT3 mRNAs and proteins between 1 and 72 h after seizure induction .
16523487	0	glucose	41,48	GLUT1	129,134	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	GLUT1-6|compound|START_ENTITY distribution|nmod|GLUT1-6 distribution|dep|localization localization|nmod|END_ENTITY	Differential subcellular distribution of glucose transporters GLUT1-6 and GLUT9 in human cancer : ultrastructural localization of GLUT1 and GLUT5 in breast_tumor tissues .
16854415	0	glucose	32,39	GLUT1	53,58	glucose	GLUT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	transporters|compound|START_ENTITY END_ENTITY|nsubj|transporters	Adult neural stem cells express glucose transporters GLUT1 and GLUT3 and regulate GLUT3 expression .
17029809	0	glucose	24,31	GLUT1	18,23	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Expression of the GLUT1 glucose transporter , p63 and p53 in thyroid_carcinomas .
17052934	1	glucose	258,265	GLUT1	291,296	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	gene|compound|START_ENTITY mutation|nmod|gene result|nmod|mutation result|appos|END_ENTITY	Glucose_transporter_type_1_deficiency_syndrome -LRB- Glut1DS -RRB- is the result of autosomal-dominant loss-of-function mutation of the glucose transporter type 1 gene -LRB- GLUT1 -RRB- leading to brain energy failure and epileptic_encephalopathy .
17320047	0	glucose	43,50	GLUT1	69,74	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transport|compound|START_ENTITY adipocyte|dobj|transport adipocyte|nmod|END_ENTITY	PACSIN3 overexpression increases adipocyte glucose transport through GLUT1 .
17389706	0	glucose	56,63	GLUT1	89,94	glucose	GLUT1	MESH:D005947	20525(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY attenuates|dobj|uptake attenuates|advcl|affecting affecting|dobj|END_ENTITY	Suppression of PPAR-gamma attenuates insulin-stimulated glucose uptake by affecting both GLUT1 and GLUT4 in 3T3-L1 adipocytes .
1740368	0	glucose	61,68	GLUT1	82,87	glucose	GLUT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY localization|nmod|transporter localization|appos|END_ENTITY	Ultracytochemical localization of the erythrocyte/HepG2-type glucose transporter -LRB- GLUT1 -RRB- in cells of the blood-retinal barrier in the rat .
1761560	0	glucose	41,48	GLUT1	31,36	glucose	GLUT1	MESH:D005947	100753506	Chemical	Gene	activity|compound|START_ENTITY role|nmod|activity role|nmod|END_ENTITY	The role of N-glycosylation of GLUT1 for glucose transport activity .
17878754	0	glucose	25,32	GLUT1	61,66	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	uptake|compound|START_ENTITY decreases|dobj|uptake decreases|nmod|downregulation downregulation|nmod|END_ENTITY	Angiotensin_II decreases glucose uptake by downregulation of GLUT1 in the cell membrane of the vascular smooth muscle cell line A10 .
18043507	0	glucose	25,32	GLUT1	19,24	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Acute effectors of GLUT1 glucose transporter subcellular targeting in CIT3 mouse mammary epithelial cells .
18177733	0	glucose	124,131	GLUT1	0,5	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	sensor|compound|START_ENTITY FRET|dobj|sensor FRET|nsubj|END_ENTITY	GLUT1 and GLUT9 as major contributors to glucose influx in HepG2 cells identified by a high sensitivity intramolecular FRET glucose sensor .
18177733	0	glucose	41,48	GLUT1	0,5	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	influx|compound|START_ENTITY contributors|nmod|influx END_ENTITY|nmod|contributors	GLUT1 and GLUT9 as major contributors to glucose influx in HepG2 cells identified by a high sensitivity intramolecular FRET glucose sensor .
18474279	0	glucose	37,44	GLUT1	89,94	glucose	GLUT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Hypoxic preconditioning up-regulates glucose transport activity and glucose transporter -LRB- GLUT1 and GLUT3 -RRB- gene expression after acute anoxic exposure in the cultured rat hippocampal neurons and astrocytes .
18650261	0	glucose	61,68	GLUT1	55,60	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	A GSK-3 / TSC2/mTOR pathway regulates glucose uptake and GLUT1 glucose transporter expression .
1868466	0	glucose	109,116	GLUT1	18,23	glucose	GLUT1	MESH:D005947	100753506	Chemical	Gene	concentrations|compound|START_ENTITY increases|nmod|concentrations increases|nsubj|Expression Expression|nmod|transporter transporter|compound|END_ENTITY	Expression of the GLUT1 glucose transporter increases thymidine uptake in Chinese_hamster ovary cells at low glucose concentrations .
1868466	0	glucose	24,31	GLUT1	18,23	glucose	GLUT1	MESH:D005947	100753506	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Expression of the GLUT1 glucose transporter increases thymidine uptake in Chinese_hamster ovary cells at low glucose concentrations .
18973239	0	glucose	22,29	GLUT1	104,109	glucose	GLUT1	MESH:D005947	100034080(Tax:9796)	Chemical	Gene	transport|compound|START_ENTITY Effects|nmod|transport Effects|nmod|expression expression|compound|END_ENTITY	Effects of hypoxia on glucose transport in primary equine chondrocytes in vitro and evidence of reduced GLUT1 gene expression in pathologic cartilage in vivo .
19533082	0	glucose	23,30	GLUT1	92,97	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	uptake|compound|START_ENTITY enhances|dobj|uptake enhances|nmod|podocytes podocytes|acl|using using|dobj|END_ENTITY	Rosiglitazone enhances glucose uptake in glomerular podocytes using the glucose transporter GLUT1 .
19686715	0	glucose	41,48	GLUT1	71,76	glucose	GLUT1	MESH:D005947	20525(Tax:10090)	Chemical	Gene	activity|compound|START_ENTITY action|nmod|activity action|nmod|END_ENTITY	Dual action of phenylarsine_oxide on the glucose transport activity of GLUT1 .
19819644	0	glucose	24,31	GLUT1	18,23	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Expression of the GLUT1 glucose transporter and p53 in carcinomas of the pancreatobiliary tract .
19912819	0	glucose	18,25	GLUT1	40,45	glucose	GLUT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	transporters|compound|START_ENTITY transporters|appos|END_ENTITY	Expression of two glucose transporters , GLUT1 and GLUT3 , in cultured_cerebellar_neurons : Evidence for neuron-specific expression of GLUT3 .
1999271	0	glucose	50,57	GLUT1	44,49	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Peptide-based radioimmunoassay specific for GLUT1 glucose transporter .
2016143	0	glucose	61,68	GLUT1	82,87	glucose	GLUT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY localization|nmod|transporter localization|appos|END_ENTITY	Ultracytochemical localization of the erythrocyte/HepG2-type glucose transporter -LRB- GLUT1 -RRB- in the ciliary body and iris of the rat eye .
2019601	0	glucose	139,146	GLUT1	133,138	glucose	GLUT1	MESH:D005947	100753506	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Substitution of leucine_for_tryptophan_412 does not abolish cytochalasin_B labeling but markedly decreases the intrinsic activity of GLUT1 glucose transporter .
2025301	0	glucose	4,11	GLUT1	34,39	glucose	GLUT1	MESH:D005947	100753506	Chemical	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	The glucose transport activity of GLUT1 is markedly decreased by substitution of a single amino_acid with a different charge at residue 415 .
2040701	0	glucose	18,25	GLUT1	58,63	glucose	GLUT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|expression expression|nmod|END_ENTITY	Decreased in vivo glucose uptake but normal expression of GLUT1 and GLUT4 in skeletal muscle of diabetic rats .
20506349	0	glucose	40,47	GLUT1	99,104	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|translocation translocation|nmod|membrane membrane|nmod|END_ENTITY	Cytokine stimulation promotes increased glucose uptake via translocation at the plasma membrane of GLUT1 in HEK293 cells .
20530155	0	glucose	91,98	GLUT1	85,90	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	High-grade transformation of adenoid_cystic_carcinomas : a study of the expression of GLUT1 glucose transporter and of mitochondrial antigen .
2055270	0	glucose	53,60	GLUT1	74,79	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	High expression levels of the `` erythroid/brain '' type glucose transporter -LRB- GLUT1 -RRB- in the basal cells of human eye conjunctiva and oral mucosa reconstituted in culture .
20955755	0	glucose	33,40	GLUT1	63,68	glucose	GLUT1	MESH:D005947	20525(Tax:10090)	Chemical	Gene	activity|compound|START_ENTITY Effects|nmod|activity Effects|nmod|END_ENTITY	Effects of cinnamaldehyde on the glucose transport activity of GLUT1 .
21343253	0	glucose	25,32	GLUT1	105,110	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	mRNAs|compound|START_ENTITY analysis|nmod|mRNAs reveals|nsubj|analysis reveals|dobj|role role|nmod|END_ENTITY	Quantitative analysis of glucose transporter mRNAs in endometrial stromal cells reveals critical role of GLUT1 in uterine receptivity .
21545824	0	glucose	32,39	GLUT1	62,67	glucose	GLUT1	MESH:D005947	20525(Tax:10090)	Chemical	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Berberine acutely activates the glucose transport activity of GLUT1 .
21966466	0	glucose	73,80	GLUT1	133,138	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	inhibitors|nmod|START_ENTITY act|nmod|inhibitors act|nmod|affinities affinities|nmod|END_ENTITY	HIV protease inhibitors act as competitive inhibitors of the cytoplasmic glucose binding site of GLUTs with differing affinities for GLUT1 and GLUT4 .
22072148	0	glucose	27,34	GLUT1	50,55	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	expression|advmod|START_ENTITY expression|appos|END_ENTITY	Prognostic significance of glucose transporter-1 -LRB- GLUT1 -RRB- gene expression in rectal_cancer after preoperative chemoradiotherapy .
22182490	0	glucose	37,44	GLUT1	64,69	glucose	GLUT1	MESH:D005947	20525(Tax:10090)	Chemical	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Nitroxyl -LRB- HNO -RRB- acutely activates the glucose uptake activity of GLUT1 .
22266962	0	glucose	98,105	GLUT1	45,50	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	uptake|compound|START_ENTITY resulting|nmod|uptake SIRT1|acl|resulting transcription|nmod|SIRT1 END_ENTITY|dobj|transcription	Hypoxanthine-xanthine oxidase down-regulates GLUT1 transcription via SIRT1 resulting in decreased glucose uptake in human placenta .
22580053	0	glucose	47,54	GLUT1	70,75	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	pattern|nmod|START_ENTITY transporter|nsubj|pattern transporter|dobj|1 1|appos|END_ENTITY	Cloning and expression pattern of facilitative glucose transporter 1 -LRB- GLUT1 -RRB- in gilthead sea bream Sparus aurata in response to salinity acclimation .
22752218	0	glucose	30,37	GLUT1	51,56	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	Expression|nmod|START_ENTITY transporters|nsubj|Expression transporters|dobj|END_ENTITY	Expression of hypoxia-related glucose transporters GLUT1 and GLUT3 in benign , malignant and non-neoplastic thyroid_lesions .
23201358	0	glucose	39,46	GLUT1	33,38	glucose	GLUT1	MESH:D005947	20512(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|astrocyte astrocyte|dep|END_ENTITY	Plastic changes in the astrocyte GLUT1 glucose transporter and beta-tubulin microtubule protein following voluntary exercise in mice .
23302780	0	glucose	37,44	GLUT1	59,64	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transporters|compound|START_ENTITY Expression|nmod|transporters Expression|appos|END_ENTITY	Expression of conventional and novel glucose transporters , GLUT1 , -9 , -10 , and -12 , in vascular smooth muscle cells .
23307114	2	glucose	314,321	GLUT1	344,349	glucose	GLUT3	MESH:D005947	25551(Tax:10116)	Chemical	Gene	progesterone|nmod|START_ENTITY proteins|amod|progesterone proteins|appos|END_ENTITY	The current study was designed to investigate the effects of progesterone on glucose transporter proteins -LRB- GLUT1 and GLUT3 -RRB- during hypoxic-ischemic_injury in a neonatal rat model .
23453806	0	glucose	73,80	GLUT1	92,97	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|END_ENTITY	AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1 .
23724114	0	glucose	42,49	GLUT1	22,27	glucose	GLUT1	MESH:D005947	102174800	Chemical	Gene	uptake|compound|START_ENTITY analyse|nmod|uptake analyse|nmod|END_ENTITY	Functional analyse of GLUT1 and GLUT12 in glucose uptake in goat mammary gland epithelial cells .
24492615	0	glucose	79,86	GLUT1	63,68	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	drives|compound|START_ENTITY reprogramming|dep|drives reprogramming|dep|glucose_transporter_1 glucose_transporter_1|appos|END_ENTITY	Metabolic reprogramming of macrophages : glucose_transporter_1 -LRB- GLUT1 -RRB- - mediated glucose metabolism drives a proinflammatory phenotype .
24894722	0	glucose	23,30	GLUT1	60,65	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transport|compound|START_ENTITY model|nmod|transport suggests|nsubj|model suggests|dobj|characteristics characteristics|compound|END_ENTITY	A theoretical model of glucose transport suggests symmetric GLUT1 characteristics at placental membranes .
25157747	0	glucose	38,45	GLUT1	32,37	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|dobj|transporter	Regulation of human trophoblast GLUT1 glucose transporter by insulin-like_growth_factor_I -LRB- IGF-I -RRB- .
25715702	0	glucose	18,25	GLUT1	54,59	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transport|compound|START_ENTITY inhibits|dobj|transport inhibits|nmod|binding binding|nmod|site site|compound|END_ENTITY	Caffeine inhibits glucose transport by binding at the GLUT1 nucleotide-binding site .
25810258	1	glucose	57,64	GLUT1	93,98	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transport|compound|START_ENTITY inhibits|dobj|transport inhibits|nmod|binding binding|nmod|site site|amod|END_ENTITY	Focus on `` Caffeine inhibits glucose transport by binding at the GLUT1 nucleotide-binding site '' .
25863194	0	glucose	29,36	GLUT1	58,63	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	defects|compound|START_ENTITY defects|nmod|transporter transporter|compound|END_ENTITY	Pathogenic mutations causing glucose transport defects in GLUT1 transporter : The role of intermolecular forces in protein structure-function .
7516306	0	glucose	40,47	GLUT1	34,39	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Affected sib-pair analysis of the GLUT1 glucose transporter gene locus in non-insulin-dependent_diabetes_mellitus -LRB- NIDDM -RRB- : evidence for no linkage .
7559581	0	glucose	54,61	GLUT1	38,43	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transporters|compound|START_ENTITY transporters|compound|END_ENTITY	The insulin-dependent biosynthesis of GLUT1 and GLUT3 glucose transporters in L6 muscle cells is mediated by distinct pathways .
7575481	3	glucose	576,583	GLUT1	570,575	glucose	GLUT1	MESH:D005947	494763(Tax:8355)	Chemical	Gene	carriers|compound|START_ENTITY carriers|compound|END_ENTITY	In this study we have evaluated the effect of insulin_and_insulin-like_growth_factor_I -LRB- IGF-I -RRB- on glucose uptake and glucose transporter distribution in Xenopus oocytes expressing mammalian GLUT4 and GLUT1 glucose carriers .
7575532	0	glucose	104,111	GLUT1	54,59	glucose	GLUT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	supplier|nmod|START_ENTITY Expression|dep|supplier Expression|nmod|glucose_transporter_1 glucose_transporter_1|appos|END_ENTITY	Expression and localization of glucose_transporter_1 -LRB- GLUT1 -RRB- in the rat oviduct : a possible supplier of glucose to embryo during early embryonic development .
7588216	0	glucose	84,91	GLUT1	78,83	glucose	GLUT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Characterization of rat GLUT5 and functional analysis of chimeric proteins of GLUT1 glucose transporter and GLUT5 fructose transporter .
7589845	0	glucose	42,49	GLUT1	36,41	glucose	GLUT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Upregulation Upregulation|nmod|END_ENTITY	Upregulation of blood-brain barrier GLUT1 glucose transporter protein and mRNA in experimental chronic hypoglycemia .
7686699	0	glucose	14,21	GLUT1	44,49	glucose	GLUT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	isoforms|compound|START_ENTITY isoforms|appos|END_ENTITY	Expression of glucose transporter isoforms -LRB- GLUT1 , GLUT2 -RRB- and activities of hexokinase , pyruvate kinase , and malic enzyme in preneoplastic and neoplastic rat renal basophilic cell lesions .
7695611	0	glucose	23,30	GLUT1	17,22	glucose	GLUT1	MESH:D005947	494763(Tax:8355)	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	A `` cysteineless '' GLUT1 glucose transporter has normal function when expressed in Xenopus oocytes .
7727404	0	glucose	41,48	GLUT1	35,40	glucose	GLUT1	MESH:D005947	494763(Tax:8355)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Role of the C-terminal tail of the GLUT1 glucose transporter in its expression and function in Xenopus_laevis oocytes .
7798027	0	glucose	54,61	GLUT1	38,43	glucose	GLUT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	transporters|compound|START_ENTITY transporters|compound|END_ENTITY	Divergent regulation of rat adipocyte GLUT1 and GLUT4 glucose transporters by GH .
7835271	0	glucose	23,30	GLUT1	65,70	glucose	GLUT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY metformin|nmod|transport Action|nmod|metformin transporter|nsubj|Action transporter|dobj|END_ENTITY	Action of metformin on glucose transport and glucose transporter GLUT1 and GLUT4 in heart muscle cells from healthy and diabetic rats .
7921415	0	glucose	19,26	GLUT1	47,52	glucose	GLUT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	isoform|compound|START_ENTITY Over-expression|nmod|isoform END_ENTITY|nsubj|Over-expression	Over-expression of glucose transporter isoform GLUT1 and hexokinase I in rat renal oncocytic tubules and oncocytomas .
7983800	0	glucose	47,54	GLUT1	72,77	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	gene|compound|START_ENTITY gene|appos|gene gene|compound|END_ENTITY	-LSB- Defects of candidate genes in Japanese NIDDM -- glucose transporter gene -LRB- GLUT1 gene , GLUT4 gene -RRB- -RSB- .
8002929	0	glucose	29,36	GLUT1	23,28	glucose	GLUT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Domain assembly of the GLUT1 glucose transporter .
8015384	0	glucose	53,60	GLUT1	47,52	glucose	GLUT1	MESH:D005947	282356(Tax:9913)	Chemical	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Enhanced expression of the blood-brain barrier GLUT1 glucose transporter gene by brain-derived factors .
8022421	0	glucose	59,66	GLUT1	80,85	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Selective inhibition by ethanol of the type 1 facilitative glucose transporter -LRB- GLUT1 -RRB- .
8037688	0	glucose	24,31	GLUT1	18,23	glucose	GLUT1	MESH:D005947	20525(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Regulation of the GLUT1 glucose transporter in cultured myocytes : total number and subcellular distribution as determined by photoaffinity labelling .
8038191	0	glucose	40,47	GLUT1	34,39	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Differential glycosylation of the GLUT1 glucose transporter in brain capillaries and choroid plexus .
8062336	0	glucose	22,29	GLUT1	95,100	glucose	GLUT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	GLUT1|compound|START_ENTITY Immunolocalization|nmod|GLUT1 Immunolocalization|dep|role role|nmod|END_ENTITY	Immunolocalization of glucose transporter GLUT1 in the rat placental barrier : possible role of GLUT1 and the gap junction in the transport of glucose across the placental barrier .
8068015	0	glucose	112,119	GLUT1	96,101	glucose	GLUT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	transporters|compound|START_ENTITY transporters|compound|END_ENTITY	Staurosporine inhibits phorbol_12-myristate_13-acetate - and insulin-stimulated translocation of GLUT1 and GLUT4 glucose transporters in rat adipose cells .
8092986	0	glucose	119,126	GLUT1	113,118	glucose	GLUT1	MESH:D005947	100753506	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Replacement of both tryptophan residues at 388 and 412 completely abolished cytochalasin_B photolabelling of the GLUT1 glucose transporter .
8093876	0	glucose	73,80	GLUT1	67,72	glucose	GLUT1	MESH:D005947	100125988(Tax:9986)	Chemical	Gene	acid|compound|START_ENTITY acid|compound|END_ENTITY	Developmental modulation of blood-brain barrier and choroid plexus GLUT1 glucose transporter messenger ribonucleic acid and immunoreactive protein in rabbits .
8098356	0	glucose	90,97	GLUT1	130,135	glucose	GLUT1	MESH:D005947	282356(Tax:9913)	Chemical	Gene	expression|compound|START_ENTITY expression|nmod|stabilization stabilization|compound|END_ENTITY	Glucose_deprivation causes posttranscriptional enhancement of brain capillary endothelial glucose transporter gene expression via GLUT1 mRNA stabilization .
8147898	0	glucose	61,68	GLUT1	20,25	glucose	GLUT1	MESH:D005947	20525(Tax:10090)	Chemical	Gene	incorporation|compound|START_ENTITY ontogeny|nmod|incorporation expression|nmod|ontogeny expression|compound|END_ENTITY	Glucose transporter GLUT1 mRNA expression in the ontogeny of glucose incorporation in mouse preimplantation embryos .
8189217	0	glucose	41,48	GLUT1	35,40	glucose	GLUT1	MESH:D005947	282356(Tax:9913)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Measurement of blood-brain barrier GLUT1 glucose transporter and actin mRNA by a quantitative polymerase chain reaction assay .
8263045	0	glucose	22,29	GLUT1	16,21	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	The human brain GLUT1 glucose transporter : ultrastructural localization to the blood-brain barrier endothelia .
8266811	0	glucose	8,15	GLUT1	56,61	glucose	GLUT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY uptake|dep|proteins proteins|nummod|END_ENTITY	In-vivo glucose uptake and glucose transporter proteins GLUT1 and GLUT3 in brain tissue from streptozotocin-diabetic rats .
8299587	0	glucose	39,46	GLUT1	125,130	glucose	GLUT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	transporters|compound|START_ENTITY expression|nmod|transporters expression|dep|down-regulation down-regulation|nmod|carriers carriers|nummod|END_ENTITY	High and polarized expression of GLUT1 glucose transporters in epithelial cells from mammary gland : acute down-regulation of GLUT1 carriers by weaning .
8299587	0	glucose	39,46	GLUT1	33,38	glucose	GLUT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	transporters|compound|START_ENTITY transporters|nummod|END_ENTITY	High and polarized expression of GLUT1 glucose transporters in epithelial cells from mammary gland : acute down-regulation of GLUT1 carriers by weaning .
8300630	0	glucose	45,52	GLUT1	26,31	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	function|compound|START_ENTITY perturbs|dobj|function perturbs|nsubj|Substitution Substitution|nmod|Pro385 Pro385|nmod|END_ENTITY	Substitution at Pro385 of GLUT1 perturbs the glucose transport function by reducing conformational flexibility .
8300643	0	glucose	45,52	GLUT1	39,44	glucose	GLUT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Overexpression of hexokinase I but not GLUT1 glucose transporter alters concentration dependence of glucose-stimulated insulin secretion in pancreatic beta-cell line MIN6 .
8323543	0	glucose	57,64	GLUT1	51,56	glucose	GLUT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Brief endotoxemia markedly increases expression of GLUT1 glucose transporter in Kupffer , hepatic endothelial and parenchymal cells .
8345816	0	glucose	33,40	GLUT1	27,32	glucose	GLUT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	Insulin therapy normalizes GLUT1 glucose transporter mRNA but not immunoreactive transporter protein in streptozocin-diabetic rats .
8360290	0	glucose	108,115	GLUT1	102,107	glucose	GLUT1	MESH:D005947	100125988(Tax:9986)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	An electron microscopic immunogold analysis of developmental up-regulation of the blood-brain barrier GLUT1 glucose transporter .
8369652	0	glucose	98,105	GLUT1	92,97	glucose	GLUT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	transcription|compound|START_ENTITY transcription|compound|END_ENTITY	Glucose transport stimulation by thyroid_hormone in ARL_15 cells : partial role of increased GLUT1 glucose transporter gene transcription .
8405361	0	glucose	68,75	GLUT1	62,67	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	The role of N-glycosylation in the targeting and stability of GLUT1 glucose transporter .
8457217	0	glucose	79,86	GLUT1	63,68	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transporters|compound|START_ENTITY transporters|compound|END_ENTITY	Effect of insulin on the rates of synthesis and degradation of GLUT1 and GLUT4 glucose transporters in 3T3-L1 adipocytes .
8473295	0	glucose	28,35	GLUT1	12,17	glucose	GLUT1	MESH:D005947	494763(Tax:8355)	Chemical	Gene	transporters|compound|START_ENTITY transporters|compound|END_ENTITY	Kinetics of GLUT1 and GLUT4 glucose transporters expressed in Xenopus oocytes .
8489512	0	glucose	32,39	GLUT1	26,31	glucose	GLUT1	MESH:D005947	100753506	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|tryptophan-388 tryptophan-388|nmod|END_ENTITY	Role of tryptophan-388 of GLUT1 glucose transporter in glucose-transport activity and photoaffinity-labelling with forskolin .
8524814	0	glucose	98,105	GLUT1	151,156	glucose	GLUT1	MESH:D005947	20525(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY elevation|nmod|transport Phosphatidylinositol|dobj|elevation Phosphatidylinositol|nmod|translocation translocation|nmod|transporter transporter|compound|END_ENTITY	Phosphatidylinositol 3-kinase binding to polyoma virus middle_tumor_antigen mediates elevation of glucose transport by increasing translocation of the GLUT1 transporter .
8526858	0	glucose	20,27	GLUT1	14,19	glucose	GLUT1	MESH:D005947	20525(Tax:10090)	Chemical	Gene	trafficking|compound|START_ENTITY trafficking|compound|END_ENTITY	Disruption of GLUT1 glucose carrier trafficking in L6E9 and Sol8 myoblasts by the phosphatidylinositol 3-kinase inhibitor wortmannin .
8526858	5	glucose	993,1000	GLUT1	968,973	glucose	GLUT1	MESH:D005947	20525(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY carriers|dep|transporter carriers|nummod|END_ENTITY	Concomitantly , immunofluorescence analysis revealed that 1 h treatment with wortmannin led to a dramatic intracellular accumulation of GLUT1 carriers -LRB- the main glucose transporter expressed in L6E9 and Sol8 myoblasts -RRB- in both cell systems .
8529803	0	glucose	16,23	GLUT1	37,42	glucose	GLUT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Insulin-induced glucose transporter -LRB- GLUT1 and GLUT4 -RRB- translocation in cardiac muscle tissue is mimicked by bradykinin .
8552293	0	glucose	112,119	GLUT1	106,111	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	Brain-derived peptides regulate the steady state levels and increase stability of the blood-brain barrier GLUT1 glucose transporter mRNA .
8557327	0	glucose	33,40	GLUT1	87,92	glucose	GLUT1	MESH:D005947	20512(Tax:10090)	Chemical	Gene	influx|compound|START_ENTITY enhancement|nmod|influx enhancement|nmod|END_ENTITY	Endotoxin-induced enhancement of glucose influx into murine peritoneal macrophages via GLUT1 .
8589457	0	glucose	36,43	GLUT1	30,35	glucose	GLUT1	MESH:D005947	396130(Tax:9031)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Characterization of the avian GLUT1 glucose transporter : differential regulation of GLUT1 and GLUT3 in chicken embryo fibroblasts .
8589457	0	glucose	36,43	GLUT1	84,89	glucose	GLUT1	MESH:D005947	396130(Tax:9031)	Chemical	Gene	transporter|compound|START_ENTITY Characterization|nmod|transporter Characterization|dep|regulation regulation|nmod|END_ENTITY	Characterization of the avian GLUT1 glucose transporter : differential regulation of GLUT1 and GLUT3 in chicken embryo fibroblasts .
8592113	0	glucose	91,98	GLUT1	85,90	glucose	GLUT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	Cis-element/cytoplasmic protein interaction within the 3 ' - untranslated region of the GLUT1 glucose transporter mRNA .
8617806	0	glucose	20,27	GLUT1	0,5	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transmembrane|dobj|START_ENTITY transmembrane|nsubj|END_ENTITY	GLUT1 transmembrane glucose pathway .
8621505	0	glucose	90,97	GLUT1	111,116	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Genistein is a natural inhibitor of hexose and dehydroascorbic_acid transport through the glucose transporter , GLUT1 .
8653559	0	glucose	36,43	GLUT1	58,63	glucose	GLUT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	transporters|compound|START_ENTITY transporters|appos|END_ENTITY	Immunohistochemical localization of glucose transporters -LRB- GLUT1 and GLUT3 -RRB- in the rat hypothalamus .
8660699	0	glucose	16,23	GLUT1	10,15	glucose	GLUT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Effect of GLUT1 glucose transporter overexpression on the stimulation of glucose transport in response to inhibition of oxidative phosphorylation .
8660699	0	glucose	73,80	GLUT1	10,15	glucose	GLUT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY stimulation|nmod|transport overexpression|nmod|stimulation overexpression|nsubj|Effect Effect|nmod|transporter transporter|compound|END_ENTITY	Effect of GLUT1 glucose transporter overexpression on the stimulation of glucose transport in response to inhibition of oxidative phosphorylation .
8662621	0	glucose	53,60	GLUT1	17,22	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transport|compound|START_ENTITY account|nmod|transport account|nsubj|Translocation Translocation|nmod|END_ENTITY	Translocation of GLUT1 does not account for elevated glucose transport in glucose-deprived 3T3-L1 adipocytes .
8670104	0	glucose	28,35	GLUT1	22,27	glucose	GLUT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Expression of the rat GLUT1 glucose transporter in the yeast Saccharomyces_cerevisiae .
8770183	0	glucose	31,38	GLUT1	50,55	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	channel|compound|START_ENTITY channel|nmod|END_ENTITY	Proposed structure of putative glucose channel in GLUT1 facilitative glucose transporter .
8770183	0	glucose	69,76	GLUT1	50,55	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY facilitative|dobj|transporter facilitative|nsubj|structure structure|nmod|channel channel|nmod|END_ENTITY	Proposed structure of putative glucose channel in GLUT1 facilitative glucose transporter .
8858913	0	glucose	87,94	GLUT1	81,86	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	mRNA|compound|START_ENTITY mRNA|nummod|END_ENTITY	Evidence for translational control elements within the 5 ' - untranslated region of GLUT1 glucose transporter mRNA .
8892317	0	glucose	21,28	GLUT1	15,20	glucose	GLUT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Stimulation of GLUT1 glucose transporter expression in response to inhibition of oxidative phosphorylation : role of reduced sulfhydryl groups .
8977147	0	glucose	78,85	GLUT1	72,77	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Brain-derived peptides increase the expression of a blood-brain barrier GLUT1 glucose transporter reporter gene .
9016941	0	glucose	87,94	GLUT1	81,86	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Synthesis of glucose-chlorambucil derivatives and their recognition by the human GLUT1 glucose transporter .
9156574	0	glucose	11,18	GLUT1	32,37	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transport|compound|START_ENTITY transport|nmod|END_ENTITY	Control of glucose transport by GLUT1 : regulated secretion in an unexpected environment .
9166756	0	glucose	92,99	GLUT1	86,91	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	Site-directed deletion of a 10-nucleotide domain of the 3 ' - untranslated region of the GLUT1 glucose transporter mRNA eliminates cytosolic protein binding in human brain_tumors and induction of reporter gene expression .
9175865	0	glucose	10,17	GLUT1	99,104	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transport|compound|START_ENTITY transport|dep|role role|nmod|N-glycosylation N-glycosylation|nmod|END_ENTITY	Increased glucose transport in ras-transformed fibroblasts : a possible role for N-glycosylation of GLUT1 .
9179927	0	glucose	30,37	GLUT1	52,57	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transporters|compound|START_ENTITY Expression|nmod|transporters Expression|appos|END_ENTITY	Expression of the facilitated glucose transporters -LRB- GLUT1 and GLUT3 -RRB- by a choriocarcinoma cell line -LRB- JAr -RRB- and cytotrophoblast cells in culture .
9226204	0	glucose	6,13	GLUT1	0,5	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	GLUT1 glucose transporter expression in benign and malignant thyroid nodules .
9230344	0	glucose	22,29	GLUT1	0,5	glucose	GLUT1	MESH:D005947	20525(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY adequate|nmod|uptake adequate|nsubj|END_ENTITY	GLUT1 is adequate for glucose uptake in GLUT2-deficient insulin-releasing beta-cells .
9321820	7	glucose	1152,1159	GLUT1	1266,1271	glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	accompanied|nsubj|START_ENTITY blocked|advcl|accompanied blocked|nsubjpass|upregulation upregulation|nmod|END_ENTITY	When high glucose -LRB- 7.6 + / - 0.1 mM -RRB- or high NEFA -LRB- 0.76 + / - 0.05 mM -RRB- levels accompanied the hyperinsulinemia , upregulation of GLUT1 was blocked .
9440223	0	glucose	36,43	GLUT1	30,35	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY transporter|dep|region region|nmod|END_ENTITY	The 5 ' - untranslated region of GLUT1 glucose transporter mRNA causes differential regulation of the translational rate in plant and animal systems .
9461536	0	glucose	146,153	GLUT1	140,145	glucose	GLUT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	transporters|compound|START_ENTITY transporters|compound|END_ENTITY	Effects of noradrenaline on the cell-surface glucose transporters in cultured brown adipocytes : novel mechanism for selective activation of GLUT1 glucose transporters .
9461536	0	glucose	45,52	GLUT1	140,145	glucose	GLUT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	noradrenaline|nmod|START_ENTITY transporters|amod|noradrenaline Effects|nmod|transporters Effects|dep|mechanism mechanism|nmod|activation activation|nmod|transporters transporters|compound|END_ENTITY	Effects of noradrenaline on the cell-surface glucose transporters in cultured brown adipocytes : novel mechanism for selective activation of GLUT1 glucose transporters .
9578091	0	glucose	6,13	GLUT1	0,5	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	GLUT1 glucose transporter : a highly sensitive marker of malignancy in body cavity effusions .
9593925	0	glucose	31,38	GLUT1	15,20	glucose	GLUT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Alterations Alterations|nmod|END_ENTITY	Alterations in GLUT1 and GLUT3 glucose transporter gene expression following unilateral hypoxia-ischemia in the immature rat brain .
9600248	0	glucose	67,74	GLUT1	61,66	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	High frequency of polymorphism but no mutations found in the GLUT1 glucose transporter gene in NIDDM and familial_obesity by SSCP analysis .
9655290	0	glucose	6,13	GLUT1	0,5	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	GLUT1 glucose transporter expression in colorectal_carcinoma : a marker for poor prognosis .
9685631	0	glucose	6,13	GLUT1	0,5	glucose	GLUT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	GLUT1 glucose transporter : differential gene transcription and mRNA binding to cytosolic and polysome proteins in brain and peripheral tissues .
9692964	0	glucose	145,152	GLUT1	139,144	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Cysteine-scanning mutagenesis of flanking regions at the boundary between external loop I or IV and transmembrane segment II or VII in the GLUT1 glucose transporter .
9700668	0	glucose	54,61	GLUT1	48,53	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|dobj|transporter	Molecular regulation of the blood-brain barrier GLUT1 glucose transporter by brain-derived factors .
9726238	0	glucose	20,27	GLUT1	89,94	glucose	GLUT1	MESH:D005947	282356(Tax:9913)	Chemical	Gene	activity|compound|START_ENTITY upregulates|dobj|activity upregulates|nmod|increase increase|nmod|expression expression|nummod|END_ENTITY	Hypoxia upregulates glucose transport activity through an adenosine-mediated increase of GLUT1 expression in retinal capillary endothelial cells .
9729315	0	glucose	70,77	GLUT1	64,69	glucose	GLUT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	Ten nucleotide cis element in the 3 ' - untranslated region of the GLUT1 glucose transporter mRNA increases gene expression via mRNA stabilization .
9832194	0	glucose	58,65	GLUT1	52,57	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Brain-derived peptides increase blood-brain barrier GLUT1 glucose transporter gene expression via mRNA stabilization .
9854024	0	glucose	32,39	GLUT1	96,101	glucose	GLUT1	MESH:D005947	20525(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY transport|nmod|muscle muscle|nmod|END_ENTITY	Insulin-sensitive regulation of glucose transport and GLUT4 translocation in skeletal muscle of GLUT1 transgenic_mice .
9878834	0	glucose	85,92	GLUT1	79,84	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	mRNA|compound|START_ENTITY mRNA|nummod|END_ENTITY	Amplification of gene expression using both 5 ' - and 3 ' - untranslated regions of GLUT1 glucose transporter mRNA .
11592815	0	glucose	46,53	GLUT10	36,42	glucose	GLUT10	MESH:D005947	81031	Chemical	Gene	transporter|compound|START_ENTITY analysis|dep|transporter analysis|nmod|END_ENTITY	Sequence and functional analysis of GLUT10 : a glucose transporter in the Type_2_diabetes-linked_region of chromosome 20q12-13 .1 .
12941788	0	glucose	32,39	GLUT10	25,31	glucose	GLUT10	MESH:D005947	81031	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Genetic variation of the GLUT10 glucose transporter -LRB- SLC2A10 -RRB- and relationships to type 2 diabetes and intermediary traits .
16336637	0	glucose	31,38	GLUT10	24,30	glucose	GLUT10	MESH:D005947	81031	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Genetic analysis of the GLUT10 glucose transporter -LRB- SLC2A10 -RRB- polymorphisms in Caucasian American type 2 diabetes .
10671373	0	glucose	80,87	GLUT2	59,64	glucose	GLUT2	MESH:D005947	6514	Chemical	Gene	involved|nmod|START_ENTITY involved|nsubjpass|loop loop|nmod|END_ENTITY	The large intracytoplasmic loop of the glucose transporter GLUT2 is involved in glucose signaling in hepatic cells .
10825458	0	glucose	51,58	GLUT2	71,76	glucose	GLUT2	MESH:D005947	25351(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY purification|nmod|transporter END_ENTITY|nsubj|purification	Characterization and partial purification of liver glucose transporter GLUT2 .
10926839	0	glucose	38,45	GLUT2	107,112	glucose	GLUT2	MESH:D005947	25351(Tax:10116)	Chemical	Gene	absorption|compound|START_ENTITY component|nmod|absorption mediated|nsubjpass|component mediated|nmod|recruitment recruitment|nmod|END_ENTITY	The diffusive component of intestinal glucose absorption is mediated by the glucose-induced recruitment of GLUT2 to the brush-border membrane .
11411796	2	glucose	318,325	GLUT2	339,344	glucose	GLUT2	MESH:D005947	25351(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	These data are needed because two weeks following injection of streptozotocin -LRB- STZ -RRB- , mRNA and protein levels of the glucose transporter , GLUT2 , are upregulated in the proximal tubule of the rat .
11562503	0	glucose	117,124	GLUT2	67,72	glucose	GLUT2	MESH:D005947	20526(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY requiring|dobj|phosphorylation pathway|acl|requiring evidence|nmod|pathway kinetics|dep|evidence kinetics|nmod|absorption absorption|nmod|absence absence|nmod|END_ENTITY	Normal kinetics of intestinal glucose absorption in the absence of GLUT2 : evidence for a transport pathway requiring glucose phosphorylation and transfer into the endoplasmic reticulum .
11562503	0	glucose	30,37	GLUT2	67,72	glucose	GLUT2	MESH:D005947	20526(Tax:10090)	Chemical	Gene	absorption|compound|START_ENTITY absorption|nmod|absence absence|nmod|END_ENTITY	Normal kinetics of intestinal glucose absorption in the absence of GLUT2 : evidence for a transport pathway requiring glucose phosphorylation and transfer into the endoplasmic reticulum .
11810292	0	glucose	42,49	GLUT2	75,80	glucose	GLUT2	MESH:D005947	6514	Chemical	Gene	SLC2A2|compound|START_ENTITY spectrum|nmod|SLC2A2 spectrum|appos|END_ENTITY	The mutation spectrum of the facilitative glucose transporter gene SLC2A2 -LRB- GLUT2 -RRB- in patients with Fanconi-Bickel_syndrome .
11942578	0	glucose	68,75	GLUT2	62,67	glucose	GLUT2	MESH:D005947	25351(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Gradual loss of pancreatic beta-cell_insulin , _ glucokinase and GLUT2 glucose transporter immunoreactivities during the time course of nutritionally induced type-2_diabetes_in_Psammomys_obesus -LRB- sand rat -RRB- .
12436338	0	glucose	24,31	GLUT2	18,23	glucose	GLUT2	MESH:D005947	25351(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Importance of the GLUT2 glucose transporter for pancreatic beta cell toxicity of alloxan .
12526103	0	glucose	50,57	GLUT2	44,49	glucose	GLUT2	MESH:D005947	25351(Tax:10116)	Chemical	Gene	promoter|compound|START_ENTITY promoter|compound|END_ENTITY	C/EBP binding activity to site F of the rat GLUT2 glucose transporter gene promoter is attenuated by c-Jun in vitro .
12750016	0	glucose	29,36	GLUT2	49,54	glucose	GLUT2	MESH:D005947	25351(Tax:10116)	Chemical	Gene	RNAs|dep|START_ENTITY RNAs|compound|END_ENTITY	Distribution of glucokinase , glucose transporter GLUT2 , sulfonylurea_receptor-1 , glucagon-like_peptide-1_receptor and neuropeptide_Y messenger RNAs in rat brain by quantitative real time RT-PCR .
12859684	0	glucose	96,103	GLUT2	67,72	glucose	GLUT2	MESH:D005947	20526(Tax:10090)	Chemical	Gene	sensing|compound|START_ENTITY involved|nmod|sensing protein|acl|involved END_ENTITY|appos|protein	Hypothalamic ependymal-glial cells express the glucose transporter GLUT2 , a protein involved in glucose sensing .
1350259	0	glucose	24,31	GLUT2	18,23	glucose	GLUT2	MESH:D005947	25351(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Colocalization of GLUT2 glucose transporter , sodium/glucose cotransporter , and gamma-glutamyl_transpeptidase in rat kidney with double-peroxidase immunocytochemistry .
1351429	0	glucose	45,52	GLUT2	21,26	glucose	GLUT2	MESH:D005947	6514	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Polymorphisms at the GLUT2 -LRB- beta-cell/liver -RRB- glucose transporter gene and non-insulin-dependent_diabetes_mellitus -LRB- NIDDM -RRB- : analysis in affected pedigree members .
1397706	0	glucose	119,126	GLUT2	113,118	glucose	GLUT2	MESH:D005947	25351(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Recovery of glucose-induced insulin secretion in a rat model of NIDDM is not accompanied by return of the B-cell GLUT2 glucose transporter .
1468587	0	glucose	19,26	GLUT2	40,45	glucose	GLUT2	MESH:D005947	25351(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY Role|nmod|transporter Role|appos|END_ENTITY	Role of liver-type glucose transporter -LRB- GLUT2 -RRB- in transport across the basolateral membrane in rat jejunum .
1631055	0	glucose	84,91	GLUT2	27,32	glucose	GLUT2	MESH:D005947	20526(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY affecting|dobj|homeostasis downregulates|advcl|affecting downregulates|dobj|END_ENTITY	-LSB- Val12 -RSB- HRAS downregulates GLUT2 in beta cells of transgenic_mice without affecting glucose homeostasis .
1639377	0	glucose	30,37	GLUT2	51,56	glucose	GLUT2	MESH:D005947	6514	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mapping the human liver/islet glucose transporter -LRB- GLUT2 -RRB- gene within a genetic linkage map of chromosome 3q using a -LRB- CA -RRB- n dinucleotide repeat polymorphism and characterization of the polymorphism in three racial groups .
1683793	0	glucose	47,54	GLUT2	68,73	glucose	GLUT2	MESH:D005947	6514	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Genetic polymorphisms at the human liver/islet glucose transporter -LRB- GLUT2 -RRB- gene locus in Caucasian and West Indian subjects with type 2 -LRB- non-insulin-dependent -RRB- diabetes mellitus .
17079719	0	glucose	169,176	GLUT2	47,52	glucose	GLUT2	MESH:D005947	396272(Tax:9031)	Chemical	Gene	changes|nmod|START_ENTITY expression|nmod|changes expression|appos|expression Sequence|dep|expression Sequence|nmod|GLUT4 GLUT4|appos|END_ENTITY	Sequence of Atlantic_cod -LRB- Gadus_morhua -RRB- GLUT4 , GLUT2 and GPDH : Developmental stage expression , tissue expression and relationship to starvation-induced changes in blood glucose .
17172639	0	glucose	29,36	GLUT2	49,54	glucose	GLUT2	MESH:D005947	6514	Chemical	Gene	transporter|compound|START_ENTITY Inhibition|nmod|transporter END_ENTITY|nsubj|Inhibition	Inhibition of the intestinal glucose transporter GLUT2 by flavonoids .
17272350	0	glucose	54,61	GLUT2	7,12	glucose	GLUT2	MESH:D005947	25351(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY END_ENTITY|dep|regulation	Apical GLUT2 and Cav1 .3 : regulation of rat intestinal glucose and calcium absorption .
1727734	0	glucose	30,37	GLUT2	16,21	glucose	GLUT2	MESH:D005947	25351(Tax:10116)	Chemical	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	Upregulation of GLUT2 mRNA by glucose , mannose , and fructose in isolated rat hepatocytes .
17495045	0	glucose	55,62	GLUT2	89,94	glucose	GLUT2	MESH:D005947	25351(Tax:10116)	Chemical	Gene	absorption|compound|START_ENTITY stimulate|dobj|absorption stimulate|nmod|END_ENTITY	Sweet taste receptors in rat small intestine stimulate glucose absorption through apical GLUT2 .
17694297	0	glucose	119,126	GLUT2	0,5	glucose	GLUT2	MESH:D005947	25351(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY proximal|parataxis|concentration proximal|nsubj|protein protein|nummod|END_ENTITY	GLUT2 protein at the rat proximal tubule brush border membrane correlates with protein_kinase_C -LRB- PKC -RRB- - betal and plasma glucose concentration .
18074013	0	glucose	41,48	GLUT2	27,32	glucose	GLUT2	MESH:D005947	20526(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY affects|dobj|homeostasis affects|nsubj|Loss Loss|nmod|detection detection|nmod|END_ENTITY	Loss of sugar detection by GLUT2 affects glucose homeostasis in mice .
18234816	0	glucose	29,36	GLUT2	40,45	glucose	GLUT2	MESH:D005947	6514	Chemical	Gene	transport|nmod|START_ENTITY transport|nmod|END_ENTITY	Osmotic water transport with glucose in GLUT2 and SGLT .
19776250	0	glucose	80,87	GLUT2	74,79	glucose	GLUT2	MESH:D005947	322493(Tax:7955)	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Evolutionary structural and functional conservation of an ortholog of the GLUT2 glucose transporter gene -LRB- SLC2A2 -RRB- in zebrafish .
21920790	0	glucose	36,43	GLUT2	0,5	glucose	GLUT2	MESH:D005947	6514	Chemical	Gene	transporter|compound|START_ENTITY transporter|nsubj|END_ENTITY	GLUT2 -LRB- SLC2A2 -RRB- is not the principal glucose transporter in human pancreatic beta cells : implications for understanding genetic association signals at this locus .
21943636	0	glucose	14,21	GLUT2	63,68	glucose	GLUT2	MESH:D005947	6514	Chemical	Gene	uptake|compound|START_ENTITY Mechanisms|nmod|uptake Mechanisms|dep|role role|nmod|END_ENTITY	Mechanisms of glucose uptake in intestinal cell lines : role of GLUT2 .
22068967	0	glucose	39,46	GLUT2	126,131	glucose	GLUT2	MESH:D005947	25351(Tax:10116)	Chemical	Gene	adaptation|nmod|START_ENTITY adaptation|dep|mechanism mechanism|nmod|recruitment recruitment|nmod|END_ENTITY	Acute enterocyte adaptation to luminal glucose : a posttranslational mechanism for rapid apical recruitment of the transporter GLUT2 .
22696037	0	glucose	14,21	GLUT2	40,45	glucose	GLUT2	MESH:D005947	6514	Chemical	Gene	transporters|compound|START_ENTITY tale|nmod|transporters tale|dep|re-emerged re-emerged|nsubj|END_ENTITY	A tale of two glucose transporters : how GLUT2 re-emerged as a contender for glucose transport into the human beta cell .
22696037	0	glucose	76,83	GLUT2	40,45	glucose	GLUT2	MESH:D005947	6514	Chemical	Gene	transport|compound|START_ENTITY contender|nmod|transport re-emerged|nmod|contender re-emerged|nsubj|END_ENTITY	A tale of two glucose transporters : how GLUT2 re-emerged as a contender for glucose transport into the human beta cell .
25671087	0	glucose	53,60	GLUT2	21,26	glucose	GLUT2	MESH:D005947	6514	Chemical	Gene	uptake|compound|START_ENTITY role|nmod|uptake have|dobj|role have|nsubj|END_ENTITY	Does apical membrane GLUT2 have a role in intestinal glucose uptake ?
7589840	0	glucose	23,30	GLUT2	17,22	glucose	GLUT2	MESH:D005947	6514	Chemical	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	Pancreatic islet GLUT2 glucose transporter mRNA and protein expression in humans with and without NIDDM .
7655441	0	glucose	38,45	GLUT2	94,99	glucose	GLUT2	MESH:D005947	25351(Tax:10116)	Chemical	Gene	rhizoma|nmod|START_ENTITY Effect|nmod|rhizoma isoform|nsubj|Effect isoform|dobj|expression expression|compound|END_ENTITY	Effect of polygonati rhizoma on blood glucose and facilitative glucose transporter isoform 2 -LRB- GLUT2 -RRB- mRNA expression in Wistar fatty rats .
7686699	0	glucose	14,21	GLUT2	51,56	glucose	GLUT2	MESH:D005947	25351(Tax:10116)	Chemical	Gene	isoforms|compound|START_ENTITY isoforms|appos|GLUT1 GLUT1|dep|END_ENTITY	Expression of glucose transporter isoforms -LRB- GLUT1 , GLUT2 -RRB- and activities of hexokinase , pyruvate kinase , and malic enzyme in preneoplastic and neoplastic rat renal basophilic cell lesions .
7929431	0	glucose	39,46	GLUT2	59,64	glucose	GLUT2	MESH:D005947	20526(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY Characterization|nmod|transporter END_ENTITY|nsubj|Characterization	Characterization of the murine high Km glucose transporter GLUT2 gene and its transcriptional regulation by glucose in a differentiated insulin-secreting cell line .
7983799	0	glucose	76,83	GLUT2	97,102	glucose	GLUT2	MESH:D005947	6514	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Candidate gene approach in Japanese NIDDM : liver/pancreatic beta cell type glucose transporter -LRB- GLUT2 -RRB- -RSB- .
8033812	0	glucose	20,27	GLUT2	14,19	glucose	GLUT2	MESH:D005947	25351(Tax:10116)	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Regulation of GLUT2 glucose transporter expression in liver by thyroid hormone : evidence for hormonal regulation of the hepatic_glucose_transport_system .
8349038	0	glucose	21,28	GLUT2	96,101	glucose	GLUT2	MESH:D005947	25351(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY derived|nmod|metabolism Signals|acl|derived required|nsubjpass|Signals required|nmod|regulation regulation|nmod|mRNA mRNA|compound|END_ENTITY	Signals derived from glucose metabolism are required for glucose regulation of pancreatic islet GLUT2 mRNA and protein .
8349038	0	glucose	57,64	GLUT2	96,101	glucose	GLUT2	MESH:D005947	25351(Tax:10116)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|mRNA mRNA|compound|END_ENTITY	Signals derived from glucose metabolism are required for glucose regulation of pancreatic islet GLUT2 mRNA and protein .
8482435	0	glucose	70,77	GLUT2	26,31	glucose	GLUT2	MESH:D005947	6514	Chemical	Gene	START_ENTITY|nsubj|Organization Organization|nmod|END_ENTITY	Organization of the human GLUT2 -LRB- pancreatic beta-cell and hepatocyte -RRB- glucose transporter gene .
8589640	0	glucose	38,45	GLUT2	32,37	glucose	GLUT2	MESH:D005947	25351(Tax:10116)	Chemical	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	Ethanol decreases the levels of GLUT2 glucose transporter mRNA in hepatocytes .
8615787	0	glucose	15,22	GLUT2	80,85	glucose	GLUT2	MESH:D005947	20526(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY Requirement|nmod|metabolism Requirement|appos|END_ENTITY	Requirement of glucose metabolism for regulation of glucose_transporter type 2 -LRB- GLUT2 -RRB- gene expression in liver .
9227491	0	glucose	66,73	GLUT2	0,5	glucose	GLUT2	MESH:D005947	397429(Tax:9823)	Chemical	Gene	metabolism|compound|START_ENTITY gradient|nmod|metabolism control|dobj|gradient control|nsubj|END_ENTITY	GLUT2 and hexokinase control proximodistal gradient of intestinal glucose metabolism in the newborn pig .
9246233	0	glucose	22,29	GLUT2	47,52	glucose	GLUT2	MESH:D005947	25351(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|compound|END_ENTITY	Synergistic effect of glucose and prolactin on GLUT2 expression in cultured neonatal rat islets .
9354798	0	glucose	48,55	GLUT2	13,18	glucose	GLUT2	MESH:D005947	6514	Chemical	Gene	transporter|compound|START_ENTITY gene|nmod|transporter Mutations|appos|gene Mutations|nmod|END_ENTITY	Mutations in GLUT2 , the gene for the liver-type glucose transporter , in patients with Fanconi-Bickel_syndrome .
9446857	0	glucose	87,94	GLUT2	81,86	glucose	GLUT2	MESH:D005947	25351(Tax:10116)	Chemical	Gene	mRNA|compound|START_ENTITY mRNA|nummod|END_ENTITY	Intracerebroventricular administration of antisense oligodeoxynucleotide against GLUT2 glucose transporter mRNA reduces food intake , body weight change and glucoprivic feeding response in rats .
9751501	0	glucose	38,45	GLUT2	32,37	glucose	GLUT2	MESH:D005947	6514	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Different functional domains of GLUT2 glucose transporter are required for glucose affinity and substrate specificity .
9751501	0	glucose	75,82	GLUT2	32,37	glucose	GLUT2	MESH:D005947	6514	Chemical	Gene	affinity|compound|START_ENTITY required|nmod|affinity required|nsubjpass|domains domains|nmod|transporter transporter|compound|END_ENTITY	Different functional domains of GLUT2 glucose transporter are required for glucose affinity and substrate specificity .
9751501	3	glucose	375,382	GLUT2	355,360	glucose	GLUT3	MESH:D005947	379400(Tax:8355)	Chemical	Gene	affinity|compound|START_ENTITY affinity|nmod:poss|END_ENTITY	To better understand the molecular determinants for GLUT2 's distinctive glucose affinity and its ability to transport fructose , we constructed a series of chimeric GLUT2/GLUT3 proteins and analyzed them in both Xenopus oocytes and mammalian cells .
9770484	0	glucose	15,22	GLUT2	52,57	glucose	GLUT2	MESH:D005947	6514	Chemical	Gene	production|compound|START_ENTITY production|nmod|absence absence|nmod|END_ENTITY	Normal hepatic glucose production in the absence of GLUT2 reveals an alternative pathway for glucose release from hepatocytes .
9770484	0	glucose	93,100	GLUT2	52,57	glucose	GLUT2	MESH:D005947	6514	Chemical	Gene	release|compound|START_ENTITY pathway|nmod|release reveals|dobj|pathway reveals|nsubj|production production|nmod|absence absence|nmod|END_ENTITY	Normal hepatic glucose production in the absence of GLUT2 reveals an alternative pathway for glucose release from hepatocytes .
9806888	0	glucose	80,87	GLUT2	74,79	glucose	GLUT2	MESH:D005947	25351(Tax:10116)	Chemical	Gene	gene|compound|START_ENTITY gene|nummod|END_ENTITY	CCAAT/enhancer binding protein regulates the promoter activity of the rat GLUT2 glucose transporter gene in liver cells .
9867217	0	glucose	219,226	GLUT2	124,129	glucose	GLUT2	MESH:D005947	20526(Tax:10090)	Chemical	Gene	concentrations|nmod|START_ENTITY transfected|nmod|concentrations transfected|nmod|insulin insulin|appos|glucose_transporter_type_2 glucose_transporter_type_2|appos|END_ENTITY	Cellular characterization of pituitary_adenoma cell line -LRB- AtT20 cell -RRB- transfected with insulin , glucose_transporter_type_2 -LRB- GLUT2 -RRB- and glucokinase genes : insulin secretion in response to physiological concentrations of glucose .
10465297	0	glucose	149,156	GLUT3	169,174	glucose	GLUT3	MESH:D005947	20527(Tax:10090)	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Maternal epidermal_growth_factor_deficiency causes fetal hypoglycemia and intrauterine_growth_retardation in mice : possible involvement of placental glucose transporter GLUT3 expression .
11170207	0	glucose	40,47	GLUT3	34,39	glucose	GLUT3	MESH:D005947	6515	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Model of the 3-D structure of the GLUT3 glucose transporter and molecular dynamics simulation of glucose transport .
11170207	0	glucose	97,104	GLUT3	34,39	glucose	GLUT3	MESH:D005947	6515	Chemical	Gene	transport|compound|START_ENTITY Model|nmod|transport Model|nmod|structure structure|nmod|transporter transporter|compound|END_ENTITY	Model of the 3-D structure of the GLUT3 glucose transporter and molecular dynamics simulation of glucose transport .
11922666	0	glucose	40,47	GLUT3	83,88	glucose	GLUT3	MESH:D005947	6515	Chemical	Gene	uptake|compound|START_ENTITY decreases|dobj|uptake decreases|advcl|causing causing|nmod|transcription transcription|compound|END_ENTITY	Amyloid beta-peptide decreases neuronal glucose uptake despite causing increase in GLUT3 mRNA transcription and GLUT3 translocation to the plasma membrane .
1417839	0	glucose	22,29	GLUT3	16,21	glucose	GLUT3	MESH:D005947	6515	Chemical	Gene	START_ENTITY|nsubj|Distribution Distribution|nmod|END_ENTITY	Distribution of GLUT3 glucose transporter protein in human tissues .
1497646	0	glucose	36,43	GLUT3	17,22	glucose	GLUT3	MESH:D005947	25551(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Detection of the GLUT3 facilitative glucose transporter in rat L6 muscle cells : regulation by cellular differentiation , insulin and insulin-like growth factor-I .
15702433	0	glucose	83,90	GLUT3	77,82	glucose	GLUT3	MESH:D005947	6515	Chemical	Gene	transporters|compound|START_ENTITY transporters|nummod|END_ENTITY	Thyroid hormone excess increases basal and insulin-stimulated recruitment of GLUT3 glucose transporters on cell surface .
16337941	0	glucose	27,34	GLUT3	92,97	glucose	GLUT3	MESH:D005947	6515	Chemical	Gene	uptake|compound|START_ENTITY regulates|dobj|uptake regulates|advcl|promoting promoting|dobj|translocation translocation|nmod|END_ENTITY	Insulin regulates neuronal glucose uptake by promoting translocation of glucose transporter GLUT3 .
1704223	0	glucose	61,68	GLUT3	82,87	glucose	GLUT3	MESH:D005947	6515	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Tissue distribution and species difference of the brain type glucose transporter -LRB- GLUT3 -RRB- .
17052401	0	glucose	27,34	GLUT3	72,77	glucose	GLUT3	MESH:D005947	25551(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY Effect|nmod|levels Effect|nmod|expression expression|nmod|mRNA mRNA|compound|END_ENTITY	-LSB- Effect of different blood glucose levels on the expression of cerebral GLUT3 mRNA in neonatal rats with hypoxia-ischemia -RSB- .
1730609	1	glucose	94,101	GLUT3	64,69	glucose	GLUT3	MESH:D005947	20527(Tax:10090)	Chemical	Gene	isoform|compound|START_ENTITY facilitative|dobj|isoform facilitative|nsubj|sequence sequence|nmod|END_ENTITY	cDNA sequence of mouse GLUT3 , the brain facilitative glucose transporter isoform , and identification of sites of expression by in situ hybridization .
18948350	0	glucose	18,25	GLUT3	38,43	glucose	GLUT3	MESH:D005947	6515	Chemical	Gene	transporter|compound|START_ENTITY role|nmod|transporter END_ENTITY|nsubj|role	Essential role of glucose transporter GLUT3 for post-implantation embryonic development .
19912819	0	glucose	18,25	GLUT3	132,137	glucose	GLUT3	MESH:D005947	25551(Tax:10116)	Chemical	Gene	transporters|compound|START_ENTITY Expression|nmod|transporters Expression|dep|Evidence Evidence|nmod|expression expression|nmod|END_ENTITY	Expression of two glucose transporters , GLUT1 and GLUT3 , in cultured_cerebellar_neurons : Evidence for neuron-specific expression of GLUT3 .
22265971	0	glucose	27,34	GLUT3	108,113	glucose	GLUT3	MESH:D005947	6515	Chemical	Gene	uptake|compound|START_ENTITY suppresses|dobj|uptake suppresses|advcl|regulating regulating|dobj|expression expression|compound|END_ENTITY	MicroRNA-195-5p suppresses glucose uptake and proliferation of human bladder_cancer T24 cells by regulating GLUT3 expression .
24011442	0	glucose	10,17	GLUT3	33,38	glucose	GLUT3	MESH:D005947	6515	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Placental glucose transporter 3 -LRB- GLUT3 -RRB- is up-regulated in human pregnancies complicated by late-onset intrauterine_growth_restriction .
7615800	0	glucose	34,41	GLUT3	18,23	glucose	GLUT3	MESH:D005947	25551(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY placental|dobj|transporter placental|nsubj|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of GLUT3 placental glucose transporter in diabetic rats .
7719721	0	glucose	74,81	GLUT3	47,52	glucose	GLUT3	MESH:D005947	25551(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|appos|transporter	Progressive hippocampal loss of immunoreactive GLUT3 , the neuron-specific glucose transporter , after global_forebrain_ischemia in the rat .
7804607	0	glucose	28,35	GLUT3	49,54	glucose	GLUT3	MESH:D005947	6515	Chemical	Gene	expression|nmod|START_ENTITY Modulation|nmod|expression transporters|nsubj|Modulation transporters|dobj|END_ENTITY	Modulation of expression of glucose transporters GLUT3 and GLUT1 by potassium and N-methyl-D-aspartate in cultured cerebellar granule neurons .
7810757	0	glucose	6,13	GLUT3	0,5	glucose	GLUT3	MESH:D005947	25551(Tax:10116)	Chemical	Gene	isoform|compound|START_ENTITY isoform|compound|END_ENTITY	GLUT3 glucose transporter isoform in rat testis : localization , effect of diabetes_mellitus , and comparison to human testis .
8013626	0	glucose	34,41	GLUT3	28,33	glucose	GLUT3	MESH:D005947	25551(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Developmental expression of GLUT3 glucose transporter in the rat brain .
8042980	0	glucose	10,17	GLUT3	4,9	glucose	GLUT3	MESH:D005947	25551(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	The GLUT3 glucose transporter is the predominant isoform in primary cultured neurons : assessment by biosynthetic and photoaffinity labelling .
8177047	0	glucose	14,21	GLUT3	50,55	glucose	GLUT3	MESH:D005947	6515	Chemical	Gene	transport|compound|START_ENTITY Regulation|nmod|transport Regulation|nmod|transporters transporters|nummod|END_ENTITY	Regulation of glucose transport and expression of GLUT3 transporters in human circulating mononuclear cells : studies in cells from insulin-dependent diabetic and nondiabetic individuals .
8198523	0	glucose	25,32	GLUT3	19,24	glucose	GLUT3	MESH:D005947	20527(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Gene expression of GLUT3 glucose transporter regulated by glucose in vivo in mouse brain and in vitro in neuronal cell cultures from rat embryos .
8198523	0	glucose	58,65	GLUT3	19,24	glucose	GLUT3	MESH:D005947	20527(Tax:10090)	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubj|expression expression|nmod|transporter transporter|compound|END_ENTITY	Gene expression of GLUT3 glucose transporter regulated by glucose in vivo in mouse brain and in vitro in neuronal cell cultures from rat embryos .
8243635	0	glucose	16,23	GLUT3	64,69	glucose	GLUT3	MESH:D005947	25551(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|dep|distribution distribution|nmod|transporter transporter|compound|END_ENTITY	Neuron-specific glucose transporter -LRB- NSGT -RRB- : CNS distribution of GLUT3 rat glucose transporter -LRB- RGT3 -RRB- in rat central neurons .
8243635	0	glucose	74,81	GLUT3	64,69	glucose	GLUT3	MESH:D005947	25551(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Neuron-specific glucose transporter -LRB- NSGT -RRB- : CNS distribution of GLUT3 rat glucose transporter -LRB- RGT3 -RRB- in rat central neurons .
8504756	0	glucose	39,46	GLUT3	33,38	glucose	GLUT3	MESH:D005947	6515	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Tissue distribution of the human GLUT3 glucose transporter .
9174356	0	glucose	45,52	GLUT3	66,71	glucose	GLUT3	MESH:D005947	6515	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Structure-function studies of the brain-type glucose transporter , GLUT3 : alanine-scanning mutagenesis of putative transmembrane helix VIII and an investigation of the role of proline residues in transport catalysis .
9253355	0	glucose	10,17	GLUT3	4,9	glucose	GLUT3	MESH:D005947	6515	Chemical	Gene	isoform|compound|START_ENTITY isoform|compound|END_ENTITY	The GLUT3 glucose transporter isoform is differentially expressed within human placental cell types .
9275091	0	glucose	112,119	GLUT3	20,25	glucose	GLUT3	MESH:D005947	25551(Tax:10116)	Chemical	Gene	transfer|nmod|START_ENTITY machinery|nmod|transfer END_ENTITY|dep|machinery	Glucose transporter GLUT3 in the rat placental barrier : a possible machinery for the transplacental transfer of glucose .
9677332	0	glucose	26,33	GLUT3	20,25	glucose	GLUT3	MESH:D005947	6515	Chemical	Gene	regulation|compound|START_ENTITY regulation|compound|END_ENTITY	Unique mechanism of GLUT3 glucose transporter regulation by prolonged energy demand : increased protein half-life .
10067838	0	glucose	144,151	GLUT4	164,169	glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	translocation|compound|START_ENTITY translocation|compound|END_ENTITY	Mechanism of hexosamine-induced insulin resistance in transgenic_mice overexpressing glutamine : fructose-6-phosphate_amidotransferase : decreased glucose transporter GLUT4 translocation and reversal by treatment with thiazolidinedione .
10098523	0	glucose	22,29	GLUT4	43,48	glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	The insulin-sensitive glucose transporter -LRB- GLUT4 -RRB- is involved in early bone growth in control and diabetic mice , but is regulated through the insulin-like_growth_factor_I_receptor .
10364199	0	glucose	72,79	GLUT4	95,100	glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	ADP-ribosylation_factor_6|nmod|START_ENTITY trafficking|amod|ADP-ribosylation_factor_6 trafficking|appos|END_ENTITY	Evidence for a role for ADP-ribosylation_factor_6 in insulin-stimulated glucose transporter-4 -LRB- GLUT4 -RRB- trafficking in 3T3-L1 adipocytes .
10448935	0	glucose	45,52	GLUT4	136,141	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	uptake|compound|START_ENTITY interaction|nmod|uptake using|nsubj|interaction using|advcl|expressing expressing|dobj|END_ENTITY	Metformin interaction with insulin-regulated glucose uptake , using the Xenopus_laevis oocyte model expressing the mammalian transporter GLUT4 .
10462693	0	glucose	24,31	GLUT4	18,23	glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	transporters|compound|START_ENTITY transporters|compound|END_ENTITY	Insulin-sensitive GLUT4 glucose transporters are colocalized with GLUT3-expressing cells and demonstrate a chemically distinct neuron-specific localization in rat brain .
10569252	0	glucose	20,27	GLUT4	14,19	glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of GLUT4 glucose transporter protein in adipose tissue and skeletal muscle from streptozotocin-induced diabetic pregnant rats .
10655495	0	glucose	68,75	GLUT4	52,57	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	transporters|compound|START_ENTITY transporters|compound|END_ENTITY	The sentrin-conjugating enzyme mUbc9 interacts with GLUT4 and GLUT1 glucose transporters and regulates transporter levels in skeletal muscle cells .
10744682	0	glucose	51,58	GLUT4	82,87	glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	esterase|nmod|START_ENTITY Association|nmod|esterase transporter|nsubj|Association transporter|dobj|compartments compartments|appos|END_ENTITY	Association of carboxyl esterase with facilitative glucose transporter isoform 4 -LRB- GLUT4 -RRB- intracellular compartments in rat adipocytes and its possible role in insulin-induced GLUT4 recruitment .
10748204	0	glucose	102,109	GLUT4	96,101	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	The MEF2A isoform is required for striated muscle-specific expression of the insulin-responsive GLUT4 glucose transporter .
10768829	0	glucose	87,94	GLUT4	42,47	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	transport|compound|START_ENTITY reduces|dobj|transport Regulation|parataxis|reduces Regulation|nmod|distribution distribution|nmod|END_ENTITY	Regulation of subcellular distribution of GLUT4 in cardiomyocytes : Rab4A reduces basal glucose transport and augments insulin responsiveness .
10834933	0	glucose	8,15	GLUT4	90,95	glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY precedes|nsubj|uptake precedes|dobj|insulin insulin|acl|signaling signaling|nmod|adipocytes adipocytes|nmod|mice mice|compound|END_ENTITY	Reduced glucose uptake precedes insulin signaling defects in adipocytes from heterozygous GLUT4 knockout mice .
10965149	0	glucose	33,40	GLUT4	27,32	glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Prenatal expression of the GLUT4 glucose transporter in the mouse .
11042465	0	glucose	55,62	GLUT4	0,5	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	uptake|compound|START_ENTITY roles|nmod|uptake END_ENTITY|dep|roles	GLUT4 and company : SNAREing roles in insulin-regulated glucose uptake .
11069765	0	glucose	89,96	GLUT4	41,46	glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY stimulation|nmod|transport explains|dobj|stimulation explains|nsubj|translocation translocation|compound|END_ENTITY	Immunoelectron microscopic evidence that GLUT4 translocation explains the stimulation of glucose transport in isolated rat white adipose cells .
11079746	0	glucose	120,127	GLUT4	77,82	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	transport|compound|START_ENTITY implications|nmod|transport treatment|dep|implications treatment|nmod|results results|nmod|mis-targeting mis-targeting|nmod|END_ENTITY	Long-term insulin treatment of 3T3-L1 adipocytes results in mis-targeting of GLUT4 : implications for insulin-stimulated glucose transport .
11145966	0	glucose	47,54	GLUT4	41,46	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	translocation|compound|START_ENTITY translocation|compound|END_ENTITY	A role for kinesin in insulin-stimulated GLUT4 glucose transporter translocation in 3T3-L1 adipocytes .
11274399	0	glucose	33,40	GLUT4	54,59	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Restoration of insulin-sensitive glucose transporter -LRB- GLUT4 -RRB- gene expression in muscle cells by the transcriptional coactivator PGC-1 .
11311245	0	glucose	34,41	GLUT4	70,75	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	uptake|compound|START_ENTITY induction|nmod|uptake induction|nmod|expression expression|compound|END_ENTITY	Akt mediates insulin induction of glucose uptake and up-regulation of GLUT4 gene expression in brown adipocytes .
11375349	0	glucose	56,63	GLUT4	180,185	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|translocation translocation|dep|role role|nmod|activation activation|amod|p38_mitogen-activated_protein_kinase p38_mitogen-activated_protein_kinase|nmod|END_ENTITY	The antihyperglycemic drug alpha-lipoic_acid stimulates glucose uptake via both GLUT4 translocation and GLUT4 activation : potential role of p38_mitogen-activated_protein_kinase in GLUT4 activation .
11375349	0	glucose	56,63	GLUT4	80,85	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|translocation translocation|compound|END_ENTITY	The antihyperglycemic drug alpha-lipoic_acid stimulates glucose uptake via both GLUT4 translocation and GLUT4 activation : potential role of p38_mitogen-activated_protein_kinase in GLUT4 activation .
11438680	0	glucose	75,82	GLUT4	69,74	glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	translocation|compound|START_ENTITY translocation|nummod|END_ENTITY	G -LRB- alpha -RRB- 11 signaling through ARF6 regulates F-actin mobilization and GLUT4 glucose transporter translocation to the plasma membrane .
11602570	0	glucose	65,72	GLUT4	59,64	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	transporters|compound|START_ENTITY transporters|compound|END_ENTITY	PYK2 as a mediator of endothelin-1 / G_alpha_11 signaling to GLUT4 glucose transporters .
11672439	0	glucose	48,55	GLUT4	0,5	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	uptake|compound|START_ENTITY stimulation|nmod|uptake precedes|dobj|stimulation precedes|nsubj|translocation translocation|compound|END_ENTITY	GLUT4 translocation precedes the stimulation of glucose uptake by insulin in muscle cells : potential activation of GLUT4 via p38_mitogen-activated_protein_kinase .
11672439	0	glucose	48,55	GLUT4	115,120	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	uptake|compound|START_ENTITY stimulation|nmod|uptake precedes|dobj|stimulation precedes|nmod|insulin insulin|dep|activation activation|nmod|END_ENTITY	GLUT4 translocation precedes the stimulation of glucose uptake by insulin in muscle cells : potential activation of GLUT4 via p38_mitogen-activated_protein_kinase .
11681787	0	glucose	31,38	GLUT4	0,5	glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY regulating|dobj|homeostasis player|acl|regulating END_ENTITY|dep|player	GLUT4 : a key player regulating glucose homeostasis ?
11694514	0	glucose	114,121	GLUT4	108,113	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	recycling|compound|START_ENTITY recycling|nummod|END_ENTITY	A phosphatidylinositol 3-kinase-independent insulin signaling pathway to N-WASP/Arp2/3 / F-actin required for GLUT4 glucose transporter recycling .
11713226	0	glucose	87,94	GLUT4	71,76	glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	transporters|compound|START_ENTITY transporters|compound|END_ENTITY	The endosomal compartment is an insulin-sensitive recruitment site for GLUT4 and GLUT1 glucose transporters in cardiac myocytes .
11842083	0	glucose	22,29	GLUT4	43,48	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	The insulin-sensitive glucose transporter , GLUT4 , interacts physically with Daxx .
11884418	0	glucose	94,101	GLUT4	114,119	glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Mice deficient in the insulin-regulated membrane aminopeptidase show substantial decreases in glucose transporter GLUT4 levels but maintain normal glucose homeostasis .
11981040	0	glucose	33,40	GLUT4	54,59	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Intracellular insulin-responsive glucose transporter -LRB- GLUT4 -RRB- distribution but not insulin-stimulated GLUT4 exocytosis and recycling are microtubule dependent .
12086937	0	glucose	42,49	GLUT4	91,96	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	myotubes|nmod|START_ENTITY exposure|nmod|myotubes decreases|nsubj|exposure decreases|dobj|translocation translocation|compound|END_ENTITY	Sustained exposure of L6 myotubes to high glucose and insulin decreases insulin-stimulated GLUT4 translocation but upregulates GLUT4 activity .
12196464	0	glucose	70,77	GLUT4	9,14	glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY effect|nmod|uptake reach|dobj|effect activation|xcomp|reach activation|nsubj|Need Need|nmod|END_ENTITY	Need for GLUT4 activation to reach maximum effect of insulin-mediated glucose uptake in brown adipocytes isolated from GLUT4myc-expressing mice .
12237511	0	glucose	64,71	GLUT4	25,30	glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	system|compound|START_ENTITY END_ENTITY|dobj|system	Thyroid hormone augments GLUT4 expression and insulin-sensitive glucose transport system in differentiating rat brown adipocytes in culture .
12393894	0	glucose	105,112	GLUT4	159,164	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	uptake|compound|START_ENTITY reduce|dobj|uptake reduce|advcl|affecting affecting|dobj|translocation translocation|compound|END_ENTITY	A dominant-negative p38 MAPK mutant and novel selective inhibitors of p38 MAPK reduce insulin-stimulated glucose uptake in 3T3-L1 adipocytes without affecting GLUT4 translocation .
12405686	0	glucose	61,68	GLUT4	27,32	glucose	GLUT4	MESH:D005947	100033939(Tax:9796)	Chemical	Gene	START_ENTITY|nsubj|Changes Changes|nmod|content content|compound|END_ENTITY	Changes in skeletal muscle GLUT4 content and muscle membrane glucose transport following 6 weeks of exercise training .
12440698	0	glucose	18,25	GLUT4	38,43	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	transporter|compound|START_ENTITY Activation|nmod|transporter END_ENTITY|nsubj|Activation	Activation of the glucose transporter GLUT4 by insulin .
12712244	0	glucose	70,77	GLUT4	46,51	glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY uncovers|nmod|uptake uncovers|dobj|contributions contributions|nmod|END_ENTITY	Indinavir uncovers different contributions of GLUT4 and GLUT1 towards glucose uptake in muscle and fat cells and tissues .
12716734	0	glucose	49,56	GLUT4	84,89	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	START_ENTITY|dobj|content content|compound|END_ENTITY	5-amino-imidazole_carboxamide_riboside increases glucose transport and cell-surface GLUT4 content in skeletal muscle from subjects with type 2 diabetes .
12750405	0	glucose	112,119	GLUT4	0,5	glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	utilization|compound|START_ENTITY required|nmod|utilization required|nsubjpass|END_ENTITY	GLUT4 , AMP kinase , but not the insulin_receptor , are required for hepatoportal glucose sensor-stimulated muscle glucose utilization .
12750405	0	glucose	79,86	GLUT4	0,5	glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	utilization|compound|START_ENTITY required|nmod|utilization required|nsubjpass|END_ENTITY	GLUT4 , AMP kinase , but not the insulin_receptor , are required for hepatoportal glucose sensor-stimulated muscle glucose utilization .
12824867	0	glucose	24,31	GLUT4	70,75	glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY stimulates|dobj|transport stimulates|nmod|translocation translocation|compound|END_ENTITY	Nitric_oxide stimulates glucose transport through insulin-independent GLUT4 translocation in 3T3-L1 adipocytes .
12974673	0	glucose	74,81	GLUT4	20,25	glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY facilitates|nmod|uptake facilitates|dobj|translocation translocation|nummod|END_ENTITY	Calpain facilitates GLUT4 vesicle translocation during insulin-stimulated glucose uptake in adipocytes .
1352872	0	glucose	39,46	GLUT4	102,107	glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY agonist|nmod|transport Effect|nmod|agonist Effect|appos|END_ENTITY	Effect of a_beta-adrenergic agonist on glucose transport and insulin-responsive glucose transporters -LRB- GLUT4 -RRB- in brown adipose tissue of control and obese fa/fa rats .
1435301	0	glucose	48,55	GLUT4	69,74	glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Time-dependent regulation of rat adipose tissue glucose transporter -LRB- GLUT4 -RRB- mRNA and protein by insulin in streptozocin-diabetic and normal rats .
14631107	0	glucose	77,84	GLUT4	106,111	glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	tolerance|compound|START_ENTITY training|nmod|tolerance effect|nmod|training END_ENTITY|nsubj|effect	Interactive effect of exercise training and growth_hormone administration on glucose tolerance and muscle GLUT4 protein expression in rats .
14664706	0	glucose	73,80	GLUT4	44,49	glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY deficiency|nmod|uptake deficiency|appos|END_ENTITY	Threshold effects of glucose_transporter-4 -LRB- GLUT4 -RRB- deficiency on cardiac glucose uptake and development of hypertrophy .
1493596	0	glucose	53,60	GLUT4	74,79	glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Effect of training and detraining on skeletal muscle glucose transporter -LRB- GLUT4 -RRB- content in rats .
15014085	0	glucose	41,48	GLUT4	61,66	glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	turnover|compound|START_ENTITY turnover|compound|END_ENTITY	Calpain system regulates muscle mass and glucose transporter GLUT4 turnover .
15113704	0	glucose	53,60	GLUT4	74,79	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	transporter|compound|START_ENTITY characterization|nmod|transporter characterization|appos|END_ENTITY	Functional characterization of an insulin-responsive glucose transporter -LRB- GLUT4 -RRB- from fish adipose tissue .
15254270	1	glucose	145,152	GLUT4	207,212	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	homeostasis|compound|START_ENTITY maintains|dobj|homeostasis maintains|advcl|regulating regulating|dobj|amount amount|nmod|transporter transporter|compound|END_ENTITY	Insulin maintains whole body blood glucose homeostasis , in part , by regulating the amount of the GLUT4 glucose transporter on the cell surface of fat and muscle cells .
15254270	1	glucose	213,220	GLUT4	207,212	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Insulin maintains whole body blood glucose homeostasis , in part , by regulating the amount of the GLUT4 glucose transporter on the cell surface of fat and muscle cells .
15364617	0	glucose	14,21	GLUT4	98,103	glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	expression|compound|START_ENTITY Regulation|nmod|expression inducer|nsubj|Regulation inducer|nmod|END_ENTITY	Regulation of glucose transporter expression in cardiac myocytes : p38 MAPK is a strong inducer of GLUT4 .
15456776	0	glucose	38,45	GLUT4	56,61	glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|END_ENTITY	Control of exercise-stimulated muscle glucose uptake by GLUT4 is dependent on glucose phosphorylation capacity in the conscious mouse .
15456776	0	glucose	78,85	GLUT4	56,61	glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	capacity|compound|START_ENTITY dependent|nmod|capacity dependent|nsubj|Control Control|nmod|uptake uptake|nmod|END_ENTITY	Control of exercise-stimulated muscle glucose uptake by GLUT4 is dependent on glucose phosphorylation capacity in the conscious mouse .
15514260	0	glucose	93,100	GLUT4	121,126	glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	level|compound|START_ENTITY level|nmod|transgenic_mice transgenic_mice|compound|END_ENTITY	Hepatic genes altered in expression by food restriction are not influenced by the low plasma glucose level in young male GLUT4 transgenic_mice .
15654919	0	glucose	28,35	GLUT4	22,27	glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Mechanisms regulating GLUT4 glucose transporter expression and glucose transport in skeletal muscle .
15797240	0	glucose	40,47	GLUT4	133,138	glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	disposal|compound|START_ENTITY improves|dobj|disposal improves|nmod|expression expression|compound|END_ENTITY	Calorie restriction improves whole-body glucose disposal and insulin resistance in association with the increased adipocyte-specific GLUT4 expression in Otsuka Long-Evans Tokushima fatty rats .
15890973	0	glucose	19,26	GLUT4	0,5	glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY facilitative|dobj|transporter facilitative|nsubj|END_ENTITY	GLUT4 facilitative glucose transporter specifically and differentially contributes to agonist-induced vascular reactivity in mouse aorta .
15914506	0	glucose	62,69	GLUT4	112,117	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	uptake|compound|START_ENTITY attenuates|dobj|uptake attenuates|advcl|inhibiting inhibiting|dobj|translocation translocation|compound|END_ENTITY	Adrenergic receptor stimulation attenuates insulin-stimulated glucose uptake in 3T3-L1 adipocytes by inhibiting GLUT4 translocation .
1599406	0	glucose	51,58	GLUT4	45,50	glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	activities|compound|START_ENTITY activities|compound|END_ENTITY	Kinetic resolution of the separate GLUT1 and GLUT4 glucose transport activities in 3T3-L1 cells .
1637303	0	glucose	43,50	GLUT4	64,69	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Phosphorylation of the adipose/muscle-type glucose transporter -LRB- GLUT4 -RRB- and its relationship to glucose transport activity .
1651337	0	glucose	51,58	GLUT4	72,77	glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Intracellular targeting of the insulin-regulatable glucose transporter -LRB- GLUT4 -RRB- is isoform specific and independent of cell type .
16513829	0	glucose	55,62	GLUT4	136,141	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	transport|compound|START_ENTITY cardiomyocyte|dobj|transport cardiomyocyte|nmod|reduction reduction|nmod|endocytosis endocytosis|nummod|END_ENTITY	Long-term metformin treatment stimulates cardiomyocyte glucose transport through an AMP-activated protein kinase-dependent reduction in GLUT4 endocytosis .
16828894	0	glucose	21,28	GLUT4	51,56	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	PI 4,5-P2 stimulates glucose transport activity of GLUT4 in the plasma membrane of 3T3-L1 adipocytes .
1705711	0	glucose	59,66	GLUT4	80,85	glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Transcriptional repression of the mouse insulin-responsive glucose transporter -LRB- GLUT4 -RRB- gene by cAMP .
1710451	0	glucose	121,128	GLUT4	142,147	glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Palmitate stimulates glucose transport in rat adipocytes by a mechanism involving translocation of the insulin sensitive glucose transporter -LRB- GLUT4 -RRB- .
1710451	0	glucose	21,28	GLUT4	142,147	glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY stimulates|dobj|transport stimulates|nmod|mechanism mechanism|nmod|translocation translocation|nmod|transporter transporter|appos|END_ENTITY	Palmitate stimulates glucose transport in rat adipocytes by a mechanism involving translocation of the insulin sensitive glucose transporter -LRB- GLUT4 -RRB- .
17158080	0	glucose	29,36	GLUT4	50,55	glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	patterns|nmod|START_ENTITY transporters|nsubj|patterns transporters|dobj|END_ENTITY	Distribution patterns of the glucose transporters GLUT4 and GLUT1 in skeletal muscles of rats -LRB- Rattus_norvegicus -RRB- , pigs -LRB- Sus_scrofa -RRB- , cows -LRB- Bos_taurus -RRB- , adult goats , goat kids -LRB- Capra_hircus -RRB- , and camels -LRB- Camelus_dromedarius -RRB- .
17382906	0	glucose	34,41	GLUT4	76,81	glucose	GLUT4	MESH:D005947	444033(Tax:8355)	Chemical	Gene	transport|compound|START_ENTITY transport|nmod|END_ENTITY	Role of SGK1 kinase in regulating glucose transport via glucose transporter GLUT4 .
17495042	0	glucose	66,73	GLUT4	60,65	glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Glucose kinetics and exercise tolerance in mice lacking the GLUT4 glucose transporter .
1756912	0	glucose	41,48	GLUT4	62,67	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Molecular scanning of insulin-responsive glucose transporter -LRB- GLUT4 -RRB- gene in NIDDM subjects .
1763064	0	glucose	50,57	GLUT4	29,34	glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY isoform|nmod|transporter isoform|compound|END_ENTITY	Phosphorylation state of the GLUT4 isoform of the glucose transporter in subfractions of the rat adipose cell : effects of insulin , adenosine , and isoproterenol .
17631270	2	glucose	345,352	GLUT4	327,332	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	uptake|compound|START_ENTITY initiate|dobj|uptake activate|xcomp|initiate activate|dobj|END_ENTITY	We recently reported that a cell permeable phosphoinositide-binding peptide induces GLUT4 recruitment as potently as insulin , but does not activate GLUT4 to initiate glucose uptake .
18492767	0	glucose	53,60	GLUT4	73,78	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	transporter|compound|START_ENTITY regulation|nmod|transporter END_ENTITY|nsubj|regulation	Transcriptional regulation of the insulin-responsive glucose transporter GLUT4 gene : from physiology to pathology .
18619553	0	glucose	54,61	GLUT4	85,90	glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY transport|nmod|translocation translocation|compound|END_ENTITY	Lipocalin-type_prostaglandin_D -LRB- 2 -RRB- _ synthase stimulates glucose transport via enhanced GLUT4 translocation .
18702730	0	glucose	126,133	GLUT4	62,67	glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	modulation|nmod|START_ENTITY role|nmod|modulation uptake|nsubj|role colocalised|parataxis|uptake colocalised|nmod|END_ENTITY	The insulin-regulated_aminopeptidase IRAP is colocalised with GLUT4 in the mouse hippocampus -- potential role in modulation of glucose uptake in neurones ?
18773891	1	glucose	98,105	GLUT4	210,215	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	uptake|compound|START_ENTITY requires|nsubj|uptake requires|xcomp|mediate mediate|dobj|translocation translocation|nmod|vesicles vesicles|nummod|END_ENTITY	Insulin-stimulated glucose uptake requires the activation of several signaling pathways to mediate the translocation and fusion of GLUT4 vesicles to the plasma membrane .
19066040	0	glucose	107,114	GLUT4	101,106	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Use of quantitative immunofluorescence microscopy to study intracellular trafficking : studies of the GLUT4 glucose transporter .
19108584	0	glucose	61,68	GLUT4	21,26	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	transporter|compound|START_ENTITY facilitated|dobj|transporter facilitated|nsubj|modeling modeling|nmod|END_ENTITY	Homology modeling of GLUT4 , an insulin regulated facilitated glucose transporter and docking studies with ATP and its inhibitors .
19122000	0	glucose	29,36	GLUT4	83,88	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	uptake|compound|START_ENTITY inhibition|nmod|uptake occurs|nsubj|inhibition occurs|advcl|affecting affecting|dobj|translocation translocation|compound|END_ENTITY	Growth_hormone inhibition of glucose uptake in adipocytes occurs without affecting GLUT4 translocation through an insulin receptor substrate-2-phosphatidylinositol 3-kinase-dependent pathway .
19326393	0	glucose	49,56	GLUT4	102,107	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	uptake|compound|START_ENTITY inhibits|dobj|uptake inhibits|advcl|altering altering|dobj|translocation translocation|compound|END_ENTITY	The Cdk5 inhibitor roscovitine strongly inhibits glucose uptake in 3T3-L1 adipocytes without altering GLUT4 translocation from internal pools to the cell surface .
19435854	0	glucose	57,64	GLUT4	111,116	glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY impairs|dobj|uptake impairs|advcl|inhibiting inhibiting|dobj|translocation translocation|compound|END_ENTITY	Oligomeric resistin impairs insulin and AICAR-stimulated glucose uptake in mouse skeletal muscle by inhibiting GLUT4 translocation .
19590752	0	glucose	55,62	GLUT4	75,80	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	localization|compound|START_ENTITY localization|compound|END_ENTITY	Rab4b is a small GTPase involved in the control of the glucose transporter GLUT4 localization in adipocyte .
19596898	0	glucose	49,56	GLUT4	69,74	glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	transcription|compound|START_ENTITY transcription|compound|END_ENTITY	Multiple signalling pathways redundantly control glucose transporter GLUT4 gene transcription in skeletal muscle .
19818356	0	glucose	87,94	GLUT4	136,141	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	uptake|compound|START_ENTITY enhances|dobj|uptake enhances|nmod|END_ENTITY	WITHDRAWN : Pycnogenol , a procyanidin-enriched extract of Pinus maritime bark , enhances glucose uptake in 3T3-L1 adipocytes by activated GLUT4 .
19945409	3	glucose	503,510	GLUT4	526,531	glucose	AS160	MESH:D005947	210789(Tax:10090)	Chemical	Gene	partitioning|compound|START_ENTITY partitioning|compound|END_ENTITY	This study demonstrates for the first time a cytoplasmic function for RIP140 : to counteract insulin-stimulated glucose transporter 4 -LRB- GLUT4 -RRB- membrane partitioning and glucose uptake in adipocytes .
2015971	0	glucose	22,29	GLUT4	42,47	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	transporter|compound|START_ENTITY Immunolocalization|nmod|transporter END_ENTITY|nsubj|Immunolocalization	Immunolocalization of glucose transporter GLUT4 within human skeletal muscle .
20371884	0	glucose	25,32	GLUT4	45,50	glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|acl|END_ENTITY	Alterations in adipocyte glucose transporter GLUT4 and circulating adiponectin and visfatin in rat adjuvant induced arthritis .
20501875	2	glucose	138,145	GLUT4	251,256	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	uptake|compound|START_ENTITY mediated|nsubjpass|uptake mediated|nmod|increases increases|nmod|levels levels|nmod|END_ENTITY	Facilitated glucose uptake into muscle fibers is mediated by increases in surface membrane levels of the glucose transporter GLUT4 via insulin - and/or muscle contraction-mediated GLUT4 translocation .
2050674	0	glucose	77,84	GLUT4	71,76	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	transporters|compound|START_ENTITY transporters|compound|END_ENTITY	Chronic treatment with insulin selectively down-regulates cell-surface GLUT4 glucose transporters in 3T3-L1 adipocytes .
20628794	0	glucose	26,33	GLUT4	49,54	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	uptake|compound|START_ENTITY influence|dobj|uptake influence|nmod|END_ENTITY	Amino_acids influence the glucose uptake through GLUT4 in CHO-K1 cells under high glucose conditions .
20628794	0	glucose	82,89	GLUT4	49,54	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	conditions|compound|START_ENTITY influence|nmod|conditions influence|nmod|END_ENTITY	Amino_acids influence the glucose uptake through GLUT4 in CHO-K1 cells under high glucose conditions .
20816811	0	glucose	25,32	GLUT4	57,62	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	uptake|compound|START_ENTITY stimulates|dobj|uptake stimulates|nmod|expression expression|compound|END_ENTITY	Pachymic_acid stimulates glucose uptake through enhanced GLUT4 expression and translocation .
20929506	0	glucose	61,68	GLUT4	97,102	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	transport|compound|START_ENTITY transport|nmod|activation activation|nmod|END_ENTITY	Cinnamic_acid , from the bark of Cinnamomum cassia , regulates glucose transport via activation of GLUT4 on L6 myotubes in a phosphatidylinositol 3-kinase-independent manner .
20938990	0	glucose	67,74	GLUT4	119,124	glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY stimulate|dobj|uptake stimulate|advcl|inducing inducing|dobj|translocation translocation|compound|END_ENTITY	Prenylated chalcones_4-hydroxyderricin and xanthoangelol stimulate glucose uptake in skeletal muscle cells by inducing GLUT4 translocation .
21474475	0	glucose	9,16	GLUT4	28,33	glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|recovery recovery|compound|END_ENTITY	Enhanced glucose uptake via GLUT4 fuels recovery from calcium overload after ischaemia-reperfusion injury in sevoflurane - but not propofol-treated hearts .
21646544	0	glucose	68,75	GLUT4	62,67	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Hyperinsulinemia leads to uncoupled insulin regulation of the GLUT4 glucose transporter and the FoxO1 transcription factor .
2189400	0	glucose	71,78	GLUT4	88,93	glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	carrier|compound|START_ENTITY carrier|appos|END_ENTITY	The phorbol_ester TPA induces a translocation of the insulin sensitive glucose carrier -LRB- GLUT4 -RRB- in fat cells .
22384078	0	glucose	99,106	GLUT4	40,45	glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY ameliorates|dobj|homeostasis ameliorates|nsubj|Rutamarin Rutamarin|nmod|inducer inducer|nmod|translocation translocation|compound|END_ENTITY	-LRB- + -RRB- - Rutamarin as a dual inducer of both GLUT4 translocation and expression efficiently ameliorates glucose homeostasis in insulin-resistant mice .
22610098	0	glucose	56,63	GLUT4	50,55	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	translocation|compound|START_ENTITY translocation|nummod|END_ENTITY	Endoproteolytic cleavage of TUG protein regulates GLUT4 glucose transporter translocation .
22610671	0	glucose	31,38	GLUT4	68,73	glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	START_ENTITY|xcomp|uptake uptake|advcl|increasing increasing|dobj|level level|compound|END_ENTITY	4-Hydroxyisoleucine stimulates glucose uptake by increasing surface GLUT4 level in skeletal muscle cells via phosphatidylinositol-3-kinase-dependent pathway .
22617471	0	glucose	14,21	GLUT4	63,68	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	transport|compound|START_ENTITY Regulation|nmod|transport Regulation|dep|control control|nmod|END_ENTITY	Regulation of glucose transport by insulin : traffic control of GLUT4 .
22663547	0	glucose	36,43	GLUT4	102,107	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	transport|compound|START_ENTITY stimulates|dobj|transport stimulates|advcl|increasing increasing|dobj|END_ENTITY	Triiodothyronine acutely stimulates glucose transport into L6 muscle cells without increasing surface GLUT4 , GLUT1 , or GLUT3 .
22828920	0	glucose	41,48	GLUT4	83,88	glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY enhance|dobj|uptake enhance|nmod|END_ENTITY	Gingerols of Zingiber officinale enhance glucose uptake by increasing cell surface GLUT4 in cultured L6 myotubes .
23292944	0	glucose	112,119	GLUT4	97,102	glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	START_ENTITY|amod|vitro vitro|xcomp|produce produce|dobj|adipocytes adipocytes|nmod|END_ENTITY	Novel method to differentiate 3T3 L1 cells in vitro to produce highly sensitive adipocytes for a GLUT4 mediated glucose uptake using fluorescent glucose analog .
23292944	0	glucose	145,152	GLUT4	97,102	glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	analog|compound|START_ENTITY using|dobj|analog uptake|xcomp|using uptake|nsubj|method method|acl|differentiate differentiate|nmod|glucose glucose|amod|vitro vitro|xcomp|produce produce|dobj|adipocytes adipocytes|nmod|END_ENTITY	Novel method to differentiate 3T3 L1 cells in vitro to produce highly sensitive adipocytes for a GLUT4 mediated glucose uptake using fluorescent glucose analog .
23546602	0	glucose	24,31	GLUT4	43,48	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|translocation translocation|compound|END_ENTITY	17b-estradiol activates glucose uptake via GLUT4 translocation and PI3K/Akt signaling pathway in MCF-7 cells .
23700164	0	glucose	38,45	GLUT4	58,63	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	transporter|compound|START_ENTITY mapping|nmod|transporter END_ENTITY|nsubj|mapping	Topology mapping of insulin-regulated glucose transporter GLUT4 using computational biology .
24229670	17	glucose	2903,2910	GLUT4	2998,3003	glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY mediated|nsubjpass|Effects mediated|advcl|regulating regulating|dobj|expression expression|compound|END_ENTITY	Effects of glucose and insulin on the myocardial cells proliferation might be mediated through regulating GLUT4 expression .
24708213	0	glucose	42,49	GLUT4	72,77	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	START_ENTITY|nmod|translocation translocation|nummod|END_ENTITY	5 ' - AMP-activated protein kinase increases glucose uptake independent of GLUT4 translocation in cardiac myocytes .
25039620	1	glucose	180,187	GLUT4	264,269	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	transport|nmod|START_ENTITY stimulates|dobj|transport stimulates|advcl|triggering triggering|dobj|translocation translocation|nmod|glucose_transporter_4 glucose_transporter_4|appos|END_ENTITY	BACKGROUND AND PURPOSE : Insulin stimulates the transport of glucose in target tissues by triggering the translocation of glucose_transporter_4 -LRB- GLUT4 -RRB- to the plasma membrane .
25129867	0	glucose	69,76	GLUT4	87,92	glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY stimulators|nmod|uptake kojic_acid|nmod|stimulators kojic_acid|nmod|translocation translocation|compound|END_ENTITY	Synthesis of heteroaryl/aryl _ kojic_acid conjugates as stimulators of glucose uptake by GLUT4 translocation .
25191549	0	glucose	42,49	GLUT4	73,78	glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	tolerance|compound|START_ENTITY improves|dobj|tolerance improves|advcl|enhancing enhancing|dobj|translocation translocation|compound|END_ENTITY	Cacao liquor procyanidin extract improves glucose tolerance by enhancing GLUT4 translocation and glucose uptake in skeletal muscle .
25344989	0	glucose	23,30	GLUT4	61,66	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	regulation|nmod|START_ENTITY uptake|nsubj|regulation uptake|nmod|END_ENTITY	Cellular regulation of glucose uptake by glucose transporter GLUT4 .
25445038	0	glucose	162,169	GLUT4	217,222	glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY attenuates|dobj|uptake attenuates|nmod|translocation translocation|nmod|END_ENTITY	Gallic_acid attenuates high-fat diet fed-streptozotocin-induced insulin resistance via partial agonism of PPARy in experimental type 2 diabetic rats and enhances glucose uptake through translocation and activation of GLUT4 in PI3K/p-Akt signaling pathway .
25969463	0	glucose	89,96	GLUT4	34,39	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	ingestion|compound|START_ENTITY muscle|nmod|ingestion translocation|nmod|muscle translocation|nsubj|Visualization Visualization|nmod|END_ENTITY	Visualization and quantitation of GLUT4 translocation in human skeletal muscle following glucose ingestion and exercise .
26455966	0	glucose	68,75	GLUT4	62,67	glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Macrophage_migration_inhibitory_factor promotes expression of GLUT4 glucose transporter through MEF2 and Zac1 in cardiomyocytes .
26629404	0	glucose	48,55	GLUT4	80,85	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	uptake|compound|START_ENTITY regulates|dobj|uptake regulates|nmod|modulation modulation|nmod|recycling recycling|compound|END_ENTITY	TUSC5 regulates insulin-mediated adipose tissue glucose uptake by modulation of GLUT4 recycling .
26897632	0	glucose	231,238	GLUT4	78,83	glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	exposed|nmod|START_ENTITY adipocytes|acl|exposed mediated|nmod|adipocytes mediated|nsubj|utilization utilization|compound|END_ENTITY	L-Cysteine supplementation increases adiponectin synthesis and secretion , and GLUT4 and glucose utilization by upregulating disulfide_bond_A-like_protein expression mediated by MCP-1 inhibition in 3T3-L1 adipocytes exposed to high glucose .
27061726	0	glucose	33,40	GLUT4	89,94	glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY governs|dobj|uptake governs|nmod|regulation regulation|nmod|translocation translocation|nummod|END_ENTITY	Rac1 governs exercise-stimulated glucose uptake in skeletal muscle through regulation of GLUT4 translocation in mice .
7479761	0	glucose	167,174	GLUT4	71,76	glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY required|nmod|uptake indicates|ccomp|required indicates|nsubj|inability inability|acl|stimulate stimulate|dobj|translocation translocation|compound|END_ENTITY	The inability of phosphatidylinositol 3-kinase activation to stimulate GLUT4 translocation indicates additional signaling pathways are required for insulin-stimulated glucose uptake .
7505214	0	glucose	67,74	GLUT4	88,93	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	The effect of intensive insulin therapy on the insulin-regulatable glucose transporter -LRB- GLUT4 -RRB- expression in skeletal muscle in type 1 diabetes .
7575481	0	glucose	65,72	GLUT4	59,64	glucose	GLUT4	MESH:D005947	444033(Tax:8355)	Chemical	Gene	translocation|compound|START_ENTITY translocation|compound|END_ENTITY	Insulin and insulin-like growth factor I -LRB- IGF-I -RRB- stimulate GLUT4 glucose transporter translocation in Xenopus oocytes .
7588207	0	glucose	14,21	GLUT4	114,119	glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	transporters|compound|START_ENTITY Regulation|nmod|transporters Regulation|dep|effect effect|nmod|expression expression|compound|END_ENTITY	Regulation of glucose transporters in cultured rat adipocytes : synergistic effect of insulin and dexamethasone on GLUT4 gene expression through promoter activation .
7657693	0	glucose	30,37	GLUT4	24,29	glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Distinct signals in the GLUT4 glucose transporter for internalization and for targeting to an insulin-responsive compartment .
7686145	0	glucose	43,50	GLUT4	63,68	glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY gene|nmod|transporter regulation|nmod|gene END_ENTITY|nsubj|regulation	Transcriptional regulation of the gene for glucose transporter GLUT4 in skeletal muscle .
7706987	0	glucose	83,90	GLUT4	77,82	glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	systems|compound|START_ENTITY systems|nummod|END_ENTITY	Effect of in vivo thyroid hormone status on insulin signalling and GLUT1 and GLUT4 glucose transport systems in rat adipocytes .
7713930	0	glucose	61,68	GLUT4	55,60	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	vesicles|compound|START_ENTITY vesicles|compound|END_ENTITY	Cellubrevin is a resident protein of insulin-sensitive GLUT4 glucose transporter vesicles in 3T3-L1 adipocytes .
7730401	0	glucose	41,48	GLUT4	35,40	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Insulin-sensitive targeting of the GLUT4 glucose transporter in L6 myoblasts is conferred by its COOH-terminal cytoplasmic tail .
7789525	0	glucose	10,17	GLUT4	4,9	glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	The GLUT4 glucose transporter and the alpha 2 subunit of the Na + , K -LRB- + -RRB- - ATPase do not localize to the same intracellular vesicles in rat skeletal muscle .
7829624	0	glucose	30,37	GLUT4	80,85	glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	disposal|compound|START_ENTITY improves|dobj|disposal improves|advcl|changing changing|dobj|levels levels|compound|END_ENTITY	Sulfonylurea therapy improves glucose disposal without changing skeletal muscle GLUT4 levels in noninsulin-dependent diabetes_mellitus subjects : a longitudinal study .
7846068	0	glucose	124,131	GLUT4	57,62	glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY effect|nmod|homeostasis Expression|dep|effect Expression|nmod|transporter transporter|appos|END_ENTITY	Expression of an insulin-responsive glucose transporter -LRB- GLUT4 -RRB- minigene in transgenic_mice : effect of exercise and role in glucose homeostasis .
7846068	0	glucose	36,43	GLUT4	57,62	glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Expression of an insulin-responsive glucose transporter -LRB- GLUT4 -RRB- minigene in transgenic_mice : effect of exercise and role in glucose homeostasis .
7876140	0	glucose	24,31	GLUT4	111,116	glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY stimulates|dobj|transport stimulates|advcl|increasing increasing|dobj|constant constant|nmod|recycling recycling|compound|END_ENTITY	Okadaic_acid stimulates glucose transport in rat adipocytes by increasing the externalization rate constant of GLUT4 recycling .
7877606	0	glucose	95,102	GLUT4	89,94	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	isoform|compound|START_ENTITY isoform|compound|END_ENTITY	Isoproterenol inhibits cyclic_AMP-mediated but not insulin-mediated translocation of the GLUT4 glucose transporter isoform .
7926286	1	glucose	111,118	GLUT4	105,110	glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	The role of GLUT4 glucose transporter expression .
7961994	0	glucose	20,27	GLUT4	80,85	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	utilization|compound|START_ENTITY utilization|acl|expressing expressing|dobj|gene gene|compound|END_ENTITY	Enhanced peripheral glucose utilization in transgenic_mice expressing the human GLUT4 gene .
7980479	0	glucose	54,61	GLUT4	48,53	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Subcellular localization and trafficking of the GLUT4 glucose transporter isoform in insulin-responsive cells .
7982884	0	glucose	32,39	GLUT4	26,31	glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Dexamethasone induces the GLUT4 glucose transporter , and responses of glucose transport to norepinephrine and insulin in primary cultures of brown adipocytes .
7983800	0	glucose	47,54	GLUT4	84,89	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	gene|compound|START_ENTITY gene|appos|gene gene|dep|gene gene|compound|END_ENTITY	-LSB- Defects of candidate genes in Japanese NIDDM -- glucose transporter gene -LRB- GLUT1 gene , GLUT4 gene -RRB- -RSB- .
8010955	0	glucose	58,65	GLUT4	79,84	glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Analysis of the co-localization of the insulin-responsive glucose transporter -LRB- GLUT4 -RRB- and the trans Golgi network marker TGN38 within 3T3-L1 adipocytes .
8119934	0	glucose	74,81	GLUT4	58,63	glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	transporters|compound|START_ENTITY transporters|compound|END_ENTITY	Perinatal_hypothyroidism impairs the normal transition of GLUT4 and GLUT1 glucose transporters from fetal to neonatal levels in heart and brown adipose tissue .
8128887	0	glucose	29,36	GLUT4	75,80	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	uptake|compound|START_ENTITY uptake|dep|importance importance|nmod|mRNA mRNA|compound|END_ENTITY	Increased insulin-stimulated glucose uptake in athletes : the importance of GLUT4 mRNA , GLUT4 protein and fibre type composition of skeletal muscle .
8128887	0	glucose	29,36	GLUT4	87,92	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	uptake|compound|START_ENTITY uptake|dep|importance importance|nmod|mRNA mRNA|appos|protein protein|compound|END_ENTITY	Increased insulin-stimulated glucose uptake in athletes : the importance of GLUT4 mRNA , GLUT4 protein and fibre type composition of skeletal muscle .
8192664	0	glucose	23,30	GLUT4	99,104	glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	activity|compound|START_ENTITY stimulation|nmod|activity stimulation|dep|increase increase|nmod|surface surface|acl|assessed assessed|advmod|as as|nmod:npmod|END_ENTITY	Insulin stimulation of glucose transport activity in rat skeletal muscle : increase in cell surface GLUT4 as assessed by photolabelling .
8224371	0	glucose	17,24	GLUT4	125,130	glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY related|nsubjpass|uptake related|nmod|changes changes|nmod|protein protein|appos|END_ENTITY	Increased muscle glucose uptake in response to chronic glyburide treatment is not related to changes in glucose_transporter -LRB- GLUT4 -RRB- protein .
8243823	1	glucose	207,214	GLUT4	201,206	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	transporters|compound|START_ENTITY transporters|compound|END_ENTITY	Heterogeneity in the number and a novel abnormality in subcellular localization of GLUT4 glucose transporters .
8300557	0	glucose	76,83	GLUT4	70,75	glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	A Leu-Leu sequence is essential for COOH-terminal targeting signal of GLUT4 glucose transporter in fibroblasts .
8325952	0	glucose	44,51	GLUT4	65,70	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Expression of the major insulin regulatable glucose transporter -LRB- GLUT4 -RRB- in skeletal muscle of noninsulin-dependent diabetic patients and healthy subjects before and after insulin infusion .
8352771	0	glucose	72,79	GLUT4	93,98	glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Cyclic_AMP-induced transcriptional repression of the insulin-responsive glucose transporter -LRB- GLUT4 -RRB- gene : identification of a promoter region required for down-regulation of transcription .
8393869	0	glucose	40,47	GLUT4	0,5	glucose	GLUT4	MESH:D005947	403673(Tax:9615)	Chemical	Gene	transport|compound|START_ENTITY phosphorylation|nmod|transport phosphorylation|compound|END_ENTITY	GLUT4 phosphorylation and inhibition of glucose transport by dibutyryl_cAMP .
8412752	0	glucose	85,92	GLUT4	79,84	glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	expression|compound|START_ENTITY expression|nummod|END_ENTITY	Effects of thiazolidinediones on glucocorticoid-induced insulin resistance and GLUT4 glucose transporter expression in rat skeletal muscle .
8421683	0	glucose	60,67	GLUT4	81,86	glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Insulin down-regulates expression of the insulin-responsive glucose transporter -LRB- GLUT4 -RRB- gene : effects on transcription and mRNA turnover .
8424658	0	glucose	38,45	GLUT4	101,106	glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY inhibits|dobj|transport inhibits|dobj|labeling labeling|nmod|carboxyl-terminus carboxyl-terminus|nummod|END_ENTITY	Genistein inhibits insulin-stimulated glucose transport and decreases immunocytochemical labeling of GLUT4 carboxyl-terminus without affecting translocation of GLUT4 in isolated rat adipocytes : additional evidence of GLUT4 activation by insulin .
8424658	0	glucose	38,45	GLUT4	160,165	glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY inhibits|dobj|transport inhibits|advcl|affecting affecting|dobj|translocation translocation|nmod|END_ENTITY	Genistein inhibits insulin-stimulated glucose transport and decreases immunocytochemical labeling of GLUT4 carboxyl-terminus without affecting translocation of GLUT4 in isolated rat adipocytes : additional evidence of GLUT4 activation by insulin .
8424658	0	glucose	38,45	GLUT4	217,222	glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY inhibits|dobj|transport inhibits|parataxis|activation activation|nsubj|evidence evidence|nmod|END_ENTITY	Genistein inhibits insulin-stimulated glucose transport and decreases immunocytochemical labeling of GLUT4 carboxyl-terminus without affecting translocation of GLUT4 in isolated rat adipocytes : additional evidence of GLUT4 activation by insulin .
8475079	0	glucose	46,53	GLUT4	67,72	glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Regulated expression of an insulin-responsive glucose transporter -LRB- GLUT4 -RRB- minigene in 3T3-L1 adipocytes and transgenic_mice .
8486618	0	glucose	51,58	GLUT4	45,50	glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Insulin action on the internalization of the GLUT4 glucose transporter in isolated rat adipocytes .
8529804	0	glucose	40,47	GLUT4	34,39	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	carriers|compound|START_ENTITY carriers|compound|END_ENTITY	Insulin-induced redistribution of GLUT4 glucose carriers in the muscle fiber .
8615819	0	glucose	56,63	GLUT4	77,82	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	transporter|compound|START_ENTITY analysis|nmod|transporter analysis|appos|END_ENTITY	Compartment ablation analysis of the insulin-responsive glucose transporter -LRB- GLUT4 -RRB- in 3T3-L1 adipocytes .
8858619	0	glucose	51,58	GLUT4	72,77	glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY Expression|nmod|transporter Expression|appos|END_ENTITY	Expression and localization of insulin-regulatable glucose transporter -LRB- GLUT4 -RRB- in rat brain .
8866555	0	glucose	154,161	GLUT4	148,153	glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Muscle subcellular localization and recruitment by insulin of glucose transporters and Na + - K + - ATPase subunits in transgenic_mice overexpressing the GLUT4 glucose transporter .
8866555	0	glucose	62,69	GLUT4	148,153	glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	transporters|compound|START_ENTITY insulin|nmod|transporters localization|nmod|insulin subunits|nsubj|localization subunits|nmod|transgenic_mice transgenic_mice|acl|overexpressing overexpressing|dobj|transporter transporter|compound|END_ENTITY	Muscle subcellular localization and recruitment by insulin of glucose transporters and Na + - K + - ATPase subunits in transgenic_mice overexpressing the GLUT4 glucose transporter .
8897005	0	glucose	18,25	GLUT4	56,61	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	transport|compound|START_ENTITY action|nmod|transport membrane|nsubj|action membrane|dobj|content content|nummod|END_ENTITY	Insulin action on glucose transport and plasma membrane GLUT4 content in skeletal muscle from patients with NIDDM .
8898098	0	glucose	61,68	GLUT4	55,60	glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Analyses of the co-localization of cellubrevin and the GLUT4 glucose transporter in rat and human insulin-responsive tissues .
8920942	0	glucose	24,31	GLUT4	47,52	glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY stimulate|dobj|uptake stimulate|nmod|translocation translocation|compound|END_ENTITY	Sulfonylureas stimulate glucose uptake through GLUT4 transporter translocation in rat skeletal muscle .
8925410	0	glucose	18,25	GLUT4	95,100	glucose	GLUT4	MESH:D005947	282359(Tax:9913)	Chemical	Gene	levels|compound|START_ENTITY assessed|nsubj|levels assessed|nmod|fragment fragment|compound|END_ENTITY	Insulin-sensitive glucose transporter transcript levels in calf muscles assessed with a bovine GLUT4 cDNA fragment .
8986782	0	glucose	42,49	GLUT4	36,41	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	transporters|compound|START_ENTITY transporters|compound|END_ENTITY	Insulin-stimulated translocation of GLUT4 glucose transporters requires SNARE-complex proteins .
9027564	0	glucose	71,78	GLUT4	92,97	glucose	GLUT4	MESH:D005947	282359(Tax:9913)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Molecular cloning and mRNA expression of the bovine insulin-responsive glucose transporter -LRB- GLUT4 -RRB- .
9048628	0	glucose	36,43	GLUT4	30,35	glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Effects of thyroid hormone on GLUT4 glucose transporter gene expression and NIDDM in rats .
9165044	0	glucose	63,70	GLUT4	47,52	glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Cyclic adenosine_3 ' ,5 ' - monophosphate regulates GLUT4 and GLUT1 glucose transporter expression and stimulates transcriptional activity of the GLUT1 promoter in muscle cells .
9165229	0	glucose	62,69	GLUT4	56,61	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	expression|compound|START_ENTITY expression|nummod|END_ENTITY	Regional variation in adipose tissue insulin action and GLUT4 glucose transporter expression in severely obese premenopausal women .
9261158	0	glucose	97,104	GLUT4	41,46	glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	stimulation|compound|START_ENTITY causes|dobj|stimulation causes|nsubj|corresponding corresponding|nmod|domain domain|compound|END_ENTITY	A synthetic peptide corresponding to the GLUT4 C-terminal cytoplasmic domain causes insulin-like glucose transport stimulation and GLUT4 recruitment in rat adipocytes .
9361698	0	glucose	49,56	GLUT4	43,48	glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	transporters|compound|START_ENTITY transporters|compound|END_ENTITY	Exercise in transgenic_mice overexpressing GLUT4 glucose transporters : effects on substrate metabolism and glycogen regulation .
9405224	0	glucose	46,53	GLUT4	67,72	glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	elements|nmod|START_ENTITY transporter|nsubj|elements transporter|dep|END_ENTITY	Regulatory elements in the insulin-responsive glucose transporter -LRB- GLUT4 -RRB- gene .
9525921	0	glucose	74,81	GLUT4	68,73	glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	transporters|compound|START_ENTITY transporters|nummod|END_ENTITY	Perturbation of dynamin II with an amphiphysin SH3 domain increases GLUT4 glucose transporters at the plasma membrane in 3T3-L1 adipocytes .
9630471	0	glucose	6,13	GLUT4	0,5	glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	GLUT4 glucose transporter expression in rodent brain : effect of diabetes .
9694838	0	glucose	34,41	GLUT4	95,100	glucose	GLUT4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	Restoration|nmod|START_ENTITY uptake|nsubj|Restoration uptake|nmod|complementation complementation|compound|END_ENTITY	Restoration of hypoxia-stimulated glucose uptake in GLUT4-deficient muscles by muscle-specific GLUT4 transgenic complementation .
9710629	0	glucose	33,40	GLUT4	53,58	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	translocation|compound|START_ENTITY translocation|compound|END_ENTITY	Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide .
9809466	0	glucose	39,46	GLUT4	33,38	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Searching for ways to upregulate GLUT4 glucose transporter expression in muscle .
9814498	6	glucose	830,837	GLUT4	824,829	glucose	GLUT4	MESH:D005947	6517	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	This study provides the first evidence that the insulin-responsive GLUT4 glucose transporter is present in human and rodent hemochorial placentas .
9895289	0	glucose	198,205	GLUT4	192,197	glucose	GLUT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	transporters|compound|START_ENTITY transporters|compound|END_ENTITY	Effects of transiently expressed atypical -LRB- zeta , lambda -RRB- , conventional -LRB- alpha , beta -RRB- and novel -LRB- delta , epsilon -RRB- protein kinase C isoforms on insulin-stimulated translocation of epitope-tagged GLUT4 glucose transporters in rat adipocytes : specific interchangeable effects of protein kinases C-zeta and C-lambda .
1530566	0	glucose	62,69	GLUT5	56,61	glucose	GLUT5	MESH:D005947	6518	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Biochemical and immunocytochemical localization of the ` GLUT5 glucose transporter ' in human skeletal muscle .
1550217	0	glucose	17,24	GLUT5	68,73	glucose	GLUT5	MESH:D005947	6518	Chemical	Gene	START_ENTITY|dobj|expression expression|nmod|END_ENTITY	Human intestinal glucose transporter expression and localization of GLUT5 .
7588216	0	glucose	84,91	GLUT5	24,29	glucose	GLUT5	MESH:D005947	65197(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY Characterization|nmod|transporter Characterization|nmod|analysis analysis|compound|rat rat|nummod|END_ENTITY	Characterization of rat GLUT5 and functional analysis of chimeric proteins of GLUT1 glucose transporter and GLUT5 fructose transporter .
10821868	0	glucose	69,76	GLUT8	0,5	glucose	GLUT8	MESH:D005947	29988	Chemical	Gene	activity|compound|START_ENTITY family|nmod|activity member|nmod|family END_ENTITY|appos|member	GLUT8 , a novel member of the sugar transport facilitator family with glucose transport activity .
10860996	0	glucose	11,18	GLUT8	0,5	glucose	GLUT8	MESH:D005947	29988	Chemical	Gene	transporter|compound|START_ENTITY transporter|nsubj|END_ENTITY	GLUT8 is a glucose transporter responsible for insulin-stimulated glucose uptake in the blastocyst .
10860996	0	glucose	66,73	GLUT8	0,5	glucose	GLUT8	MESH:D005947	29988	Chemical	Gene	uptake|compound|START_ENTITY responsible|nmod|uptake transporter|amod|responsible transporter|nsubj|END_ENTITY	GLUT8 is a glucose transporter responsible for insulin-stimulated glucose uptake in the blastocyst .
11689004	0	glucose	87,94	GLUT8	6,11	glucose	GLUT8	MESH:D005947	56017(Tax:10090)	Chemical	Gene	adipocytes|nmod|START_ENTITY expression|nmod|adipocytes organization|nmod|expression END_ENTITY|dep|organization	Mouse GLUT8 : genomic organization and regulation of expression in 3T3-L1 adipocytes by glucose .
11911870	0	glucose	6,13	GLUT8	0,5	glucose	GLUT8	MESH:D005947	85256(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|nummod|END_ENTITY	GLUT8 glucose transporter is localized to excitatory and inhibitory neurons in the rat hippocampus .
12271485	0	glucose	11,18	GLUT8	66,71	glucose	GLUT8	MESH:D005947	85256(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY stimulates|nsubj|administration stimulates|dobj|translocation translocation|nmod|transporter transporter|compound|END_ENTITY	Peripheral glucose administration stimulates the translocation of GLUT8 glucose transporter to the endoplasmic reticulum in the rat hippocampus .
12271485	0	glucose	72,79	GLUT8	66,71	glucose	GLUT8	MESH:D005947	85256(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Peripheral glucose administration stimulates the translocation of GLUT8 glucose transporter to the endoplasmic reticulum in the rat hippocampus .
15047021	0	glucose	38,45	GLUT8	32,37	glucose	GLUT8	MESH:D005947	85256(Tax:10116)	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Biphasic effects of stress upon GLUT8 glucose transporter expression and trafficking in the diabetic rat hippocampus .
15741607	0	glucose	26,33	GLUT8	20,25	glucose	GLUT8	MESH:D005947	56017(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Localization of the GLUT8 glucose transporter in murine kidney and regulation in vivo in nondiabetic and diabetic conditions .
16388010	0	glucose	27,34	GLUT8	47,52	glucose	GLUT8	MESH:D005947	56017(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY expression|nmod|transporter END_ENTITY|nsubj|expression	Differential expression of glucose transporter GLUT8 during mouse spermatogenesis .
18461434	0	glucose	12,19	GLUT8	32,37	glucose	GLUT8	MESH:D005947	56017(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY Deletion|nmod|transporter END_ENTITY|nsubj|Deletion	Deletion of glucose transporter GLUT8 in mice increases_locomotor_activity .
19808778	1	glucose	109,116	GLUT9	148,153	glucose	GLUT2	MESH:D005947	20526(Tax:10090)	Chemical	Gene	transporters|compound|START_ENTITY transporters|nmod|END_ENTITY	Facilitative glucose transporters -LRB- GLUTs -RRB- including GLUT9 , accelerate the facilitative diffusion of glucose across the plasma membrane .
16125330	0	glucose	18,25	GLUT_1	72,78	glucose	GLUT 1	MESH:D005947	6513	Chemical	Gene	uptake|compound|START_ENTITY explain|dep|uptake explain|nsubj|deficits deficits|compound|END_ENTITY	Impaired neuronal glucose uptake in pathogenesis of schizophrenia - can GLUT_1 and GLUT_3 deficits explain imaging , post-mortem and pharmacological findings ?
1644862	0	glucose	14,21	GLUT_1	36,42	glucose	GLUT 1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	transporters|compound|START_ENTITY transporters|appos|END_ENTITY	Expression of glucose transporters -LRB- GLUT_1 and GLUT_4 -RRB- in primary cultured rat adipocytes : differential evolution with time and chronic insulin effect .
8270137	0	glucose	86,93	GLUT_1	52,58	glucose	GLUT 1	MESH:D005947	6513	Chemical	Gene	affects|nmod|START_ENTITY affects|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of the high-affinity glucose transporter GLUT_1 affects the sensitivity to glucose in a hamster-derived_pancreatic_beta_cell_line -LRB- HIT -RRB- .
8364915	0	glucose	31,38	GLUT_1	134,140	glucose	GLUT 1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	protein|compound|START_ENTITY expression|nmod|protein Reduction|nmod|expression GLUT_2|nsubj|Reduction GLUT_2|nmod|preneoplastic_and_neoplastic_hepatic_lesions preneoplastic_and_neoplastic_hepatic_lesions|nmod|END_ENTITY	Reduction in the expression of glucose transporter protein GLUT_2 in preneoplastic_and_neoplastic_hepatic_lesions and reexpression of GLUT_1 in late stages of hepatocarcinogenesis .
8645185	0	glucose	36,43	GLUT_1	29,35	glucose	GLUT 1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|nummod|END_ENTITY	Functional expression of rat GLUT_1 glucose transporter in Dictyostelium_discoideum .
1282477	0	glucose	58,65	GLUT_2	79,85	glucose	GLUT 2	MESH:D005947	25351(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Differential expression of rat pancreatic islet beta-cell glucose transporter -LRB- GLUT_2 -RRB- , proinsulin and islet amyloid polypeptide genes after prolonged fasting , insulin-induced hypoglycaemia and dexamethasone treatment .
7664639	0	glucose	22,29	GLUT_2	15,21	glucose	GLUT 2	MESH:D005947	432042(Tax:8355)	Chemical	Gene	protein|compound|START_ENTITY protein|nummod|END_ENTITY	Two regions of GLUT_2 glucose transporter protein are responsible for its distinctive affinity for glucose .
7664639	0	glucose	99,106	GLUT_2	15,21	glucose	GLUT 2	MESH:D005947	432042(Tax:8355)	Chemical	Gene	affinity|nmod|START_ENTITY responsible|nmod|affinity responsible|nsubj|regions regions|nmod|protein protein|nummod|END_ENTITY	Two regions of GLUT_2 glucose transporter protein are responsible for its distinctive affinity for glucose .
8063045	0	glucose	61,68	GLUT_2	53,59	glucose	GLUT 2	MESH:D005947	6514	Chemical	Gene	START_ENTITY|nsubj|Variability Variability|nmod|cell/liver cell/liver|appos|END_ENTITY	Variability of the pancreatic islet beta cell/liver -LRB- GLUT_2 -RRB- glucose transporter gene in NIDDM patients .
8364915	0	glucose	31,38	GLUT_2	59,65	glucose	GLUT 2	MESH:D005947	25351(Tax:10116)	Chemical	Gene	protein|compound|START_ENTITY expression|nmod|protein Reduction|nmod|expression END_ENTITY|nsubj|Reduction	Reduction in the expression of glucose transporter protein GLUT_2 in preneoplastic_and_neoplastic_hepatic_lesions and reexpression of GLUT_1 in late stages of hepatocarcinogenesis .
9218418	0	glucose	93,100	GLUT_2	12,18	glucose	GLUT 2	MESH:D005947	20526(Tax:10090)	Chemical	Gene	transporter|nmod|START_ENTITY transporter|nsubj|Role Role|nmod|glucose glucose|compound|END_ENTITY	Role of the GLUT_2 glucose transporter in the response of the L-type_pyruvate_kinase gene to glucose in liver-derived cells .
9804063	0	glucose	74,81	GLUT_2	96,102	glucose	GLUT 2	MESH:D005947	6514	Chemical	Gene	transporters|compound|START_ENTITY transporters|appos|END_ENTITY	Effect of recombinant human insulin-like growth factor-I on expression of glucose transporters , GLUT_2 and GLUT_4 , in streptozotocin-diabetic rat .
8405736	2	glucose	342,349	GLUT_3	363,369	glucose	GLUT-3	MESH:D005947	25551(Tax:10116)	Chemical	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	Erythrocyte-type glucose transporter -LRB- GLUT_1 -RRB- and brain-type glucose transporter -LRB- GLUT_3 -RRB- mRNA were expressed in embryo and yolk sac .
1999492	1	glucose	141,148	GLUT_4	162,168	glucose	GLUT 4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Selective increase in the adipose cell/muscle glucose transporter -LRB- GLUT_4 -RRB- expression .
22153520	0	glucose	35,42	GLUT_4	75,81	glucose	GLUT 4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY increases|dobj|uptake increases|nmod|up-regulation up-regulation|nmod|END_ENTITY	Silk protein hydrolysate increases glucose uptake through up-regulation of GLUT_4 and reduces the expression of leptin in 3T3-L1 fibroblast .
7796936	0	glucose	34,41	GLUT_4	13,19	glucose	GLUT 4	MESH:D005947	6517	Chemical	Gene	mechanism|amod|START_ENTITY expression|dep|mechanism expression|compound|END_ENTITY	Hypothalamic GLUT_4 expression : a glucose - and insulin-sensing mechanism ?
8043894	0	glucose	24,31	GLUT_4	110,116	glucose	GLUT 4	MESH:D005947	6517	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|nmod|transporter transporter|appos|END_ENTITY	Effects of glipizide on glucose metabolism and muscle content of the insulin-regulatable glucose transporter -LRB- GLUT_4 -RRB- and glycogen synthase activity during hyperglycaemia in type 2 diabetic patients .
8043894	0	glucose	89,96	GLUT_4	110,116	glucose	GLUT 4	MESH:D005947	6517	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Effects of glipizide on glucose metabolism and muscle content of the insulin-regulatable glucose transporter -LRB- GLUT_4 -RRB- and glycogen synthase activity during hyperglycaemia in type 2 diabetic patients .
9630683	0	glucose	62,69	GLUT_4	16,22	glucose	GLUT 4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY regulating|dobj|transport transporter|acl|regulating transporter|compound|END_ENTITY	The role of the GLUT_4 transporter in regulating rat myoblast glucose transport processes .
7744717	0	glucose	40,47	GLUT_5	61,67	glucose	GLUT 5	MESH:D005947	6518	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Postnatal expression of the facilitated glucose transporter , GLUT_5 , in gerbil outer hair cells .
24296356	0	glucose	45,52	GPR4	30,34	glucose	GPR4	MESH:D005947	319197(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY modulates|dobj|homeostasis modulates|nsubj|END_ENTITY	The proton-activated receptor GPR4 modulates glucose homeostasis by increasing_insulin_sensitivity .
20335112	0	glucose	6,13	GRK2	27,31	glucose	GRK2	MESH:D005947	156	Chemical	Gene	up-regulates|compound|START_ENTITY END_ENTITY|nsubj|up-regulates	-LSB- High glucose up-regulates GRK2 gene expression in H9C2 cardiomyoblasts in vitro -RSB- .
21253590	0	glucose	68,75	GSK-3a	57,63	glucose	GSK-3a	MESH:D005947	606496(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	Tissue-specific analysis of glycogen_synthase_kinase-3a -LRB- GSK-3a -RRB- in glucose metabolism : effect of strain variation .
19505532	0	glucose	25,32	GSK-3beta	0,9	glucose	GSK-3beta	MESH:D005947	2932	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	GSK-3beta and control of glucose metabolism and insulin action in human skeletal muscle .
15488897	0	glucose	19,26	GTPCH1	61,67	glucose	GTPCH1	MESH:D005947	2643	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|END_ENTITY	The effect of high glucose on NO and O2 - through endothelial GTPCH1 and NADPH oxidase .
6752641	0	glucose	93,100	Gastric_inhibitory_polypeptide	0,30	glucose	Gastric inhibitory polypeptide	MESH:D005947	2695	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|END_ENTITY	Gastric_inhibitory_polypeptide -LRB- GIP -RRB- and insulin release in response to oral and intravenous glucose in uremic patients .
16338009	0	glucose	35,42	Ghrelin	0,7	glucose	Ghrelin	MESH:D005947	59301(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY stimulates|dobj|uptake stimulates|nsubj|END_ENTITY	Ghrelin stimulates insulin-induced glucose uptake in adipocytes .
19289146	0	glucose	43,50	Ghrelin	0,7	glucose	Ghrelin	MESH:D005947	59301(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY apoptosis|acl|induced inhibits|dobj|apoptosis inhibits|nsubj|END_ENTITY	Ghrelin inhibits apoptosis induced by high glucose and sodium_palmitate in adult rat cardiomyocytes through the PI3K-Akt signaling pathway .
22391948	0	glucose	39,46	Ghrelin	0,7	glucose	Ghrelin	MESH:D005947	58991(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY derangements|nmod|metabolism contributes|nmod|derangements contributes|nsubj|END_ENTITY	Ghrelin contributes to derangements of glucose metabolism induced by rapamycin in mice .
22783041	0	glucose	51,58	Ghrelin	0,7	glucose	Ghrelin	MESH:D005947	100861189	Chemical	Gene	regulator|compound|START_ENTITY stimulator|nmod|regulator life|dep|stimulator life|nmod:poss|END_ENTITY	Ghrelin 's second life : from appetite stimulator to glucose regulator .
24472858	0	glucose	50,57	Ghrelin	0,7	glucose	Ghrelin	MESH:D005947	58991(Tax:10090)	Chemical	Gene	level|compound|START_ENTITY increases|dobj|level increases|nsubj|administered administered|compound|END_ENTITY	Ghrelin administered spinally increases the blood glucose level in mice .
25979074	0	glucose	28,35	Ghrelin	0,7	glucose	Ghrelin	MESH:D005947	58991(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY restores|dobj|homeostasis restores|nsubj|inhibition inhibition|compound|END_ENTITY	Ghrelin inhibition restores glucose homeostasis in hepatocyte nuclear factor-1alpha -LRB- MODY3 -RRB- deficient mice .
22363679	0	glucose	58,65	Gis1	0,4	glucose	Gis1	MESH:D005947	851670(Tax:4932)	Chemical	Gene	regulate|nmod|START_ENTITY regulate|nsubj|END_ENTITY	Gis1 and Rph1 regulate glycerol and acetate metabolism in glucose depleted yeast cells .
1916052	6	glucose	1446,1453	GluT2	1428,1433	glucose	GluT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY protein|appos|transporter protein|amod|END_ENTITY	GluT2 -LRB- liver-type glucose transporter -RRB- protein and mRNA in the liver were also decreased in the aged rats , while no apparent decrease in GluT1 -LRB- HepG2/brain-type glucose transporter -RRB- protein/mg of cellular membrane protein was observed in the skeletal muscle and fat tissues of the aged rats compared with the young rats .
1916052	6	glucose	1589,1596	GluT2	1428,1433	glucose	GluT1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY protein/mg|appos|transporter decrease|nmod|protein/mg observed|nsubjpass|decrease decreased|advcl|observed decreased|nsubjpass|protein protein|amod|END_ENTITY	GluT2 -LRB- liver-type glucose transporter -RRB- protein and mRNA in the liver were also decreased in the aged rats , while no apparent decrease in GluT1 -LRB- HepG2/brain-type glucose transporter -RRB- protein/mg of cellular membrane protein was observed in the skeletal muscle and fat tissues of the aged rats compared with the young rats .
1916052	0	glucose	22,29	GluT4	93,98	glucose	GluT4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	isoforms|compound|START_ENTITY expression|nmod|isoforms expression|dep|decrease decrease|nmod|END_ENTITY	Altered expression of glucose transporter isoforms with aging in rats -- selective decrease in GluT4 in the fat tissue and skeletal muscle .
22357961	0	glucose	64,71	Glucagon-like_peptide_1	0,23	glucose	Glucagon-like peptide 1	MESH:D005947	2641	Chemical	Gene	use|compound|START_ENTITY recruits|dobj|use recruits|nsubj|END_ENTITY	Glucagon-like_peptide_1 recruits microvasculature and increases glucose use in muscle via a nitric_oxide-dependent mechanism .
9703326	0	glucose	86,93	Glucagon-like_peptide_1	0,23	glucose	Glucagon-like peptide 1	MESH:D005947	2641	Chemical	Gene	sense|nmod|START_ENTITY beta-cell|acl|sense ability|nmod|beta-cell improves|dobj|ability improves|nsubj|END_ENTITY	Glucagon-like_peptide_1 improves the ability of the beta-cell to sense and respond to glucose in subjects with impaired_glucose_tolerance .
9892226	0	glucose	80,87	Glucagon-like_peptide_1	0,23	glucose	Glucagon-like peptide 1	MESH:D005947	2641	Chemical	Gene	control|nmod|START_ENTITY role|nmod|control has|dobj|role has|nsubj|END_ENTITY	Glucagon-like_peptide_1 has a physiological role in the control of postprandial glucose in humans : studies with the antagonist exendin 9-39 .
10542207	0	glucose	36,43	Glucokinase	0,11	glucose	Glucokinase	MESH:D005947	24385(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|restores restores|amod|END_ENTITY	Glucokinase overexpression restores glucose utilization and storage in cultured hepatocytes from male Zucker_diabetic_fatty_rats .
11207441	0	glucose	143,150	Glucokinase	0,11	glucose	Glucokinase	MESH:D005947	100135866(Tax:8022)	Chemical	Gene	meal|nmod|START_ENTITY induced|nmod|meal induced|nsubj|END_ENTITY	Glucokinase is highly induced and glucose-6-phosphatase poorly repressed in liver of rainbow_trout -LRB- Oncorhynchus_mykiss -RRB- by a single meal with glucose .
11782883	0	glucose	102,109	Glucokinase	0,11	glucose	Glucokinase	MESH:D005947	24385(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY improves|dobj|uptake improves|nsubj|transfer transfer|amod|END_ENTITY	Glucokinase gene transfer to skeletal muscle of diabetic_Zucker_fatty_rats improves insulin-sensitive glucose uptake .
15929862	0	glucose	13,20	Glucokinase	0,11	glucose	Glucokinase	MESH:D005947	2645	Chemical	Gene	homeostasis|nsubj|START_ENTITY homeostasis|advmod|END_ENTITY	Glucokinase , glucose homeostasis , and diabetes_mellitus .
16921397	0	glucose	17,24	Glucokinase	46,57	glucose	Glucokinase	MESH:D005947	24385(Tax:10116)	Chemical	Gene	START_ENTITY|acl|lowering lowering|nmod|END_ENTITY	Predictive blood glucose lowering efficacy by Glucokinase activators in high fat fed female Zucker rats .
17353190	0	glucose	113,120	Glucokinase	0,11	glucose	Glucokinase	MESH:D005947	103988(Tax:10090)	Chemical	Gene	phenotype|compound|START_ENTITY predicting|dobj|phenotype factors|acl|predicting factors|nsubj|thermolability thermolability|amod|END_ENTITY	Glucokinase thermolability and hepatic regulatory protein binding are essential factors for predicting the blood glucose phenotype of missense mutations .
18974968	0	glucose	59,66	Glucokinase	0,11	glucose	Glucokinase	MESH:D005947	2645	Chemical	Gene	sensor|compound|START_ENTITY sensor|nsubj|END_ENTITY	Glucokinase , the pancreatic_glucose_sensor , is not the gut glucose sensor .
2189759	0	glucose	15,22	Glucokinase	0,11	glucose	Glucokinase	MESH:D005947	2645	Chemical	Gene	sensor|compound|START_ENTITY END_ENTITY|nmod|sensor	Glucokinase as glucose sensor and metabolic signal generator in pancreatic beta-cells and hepatocytes .
25485685	0	glucose	54,61	Glucokinase	0,11	glucose	Glucokinase	MESH:D005947	24385(Tax:10116)	Chemical	Gene	intake|compound|START_ENTITY regulates|dobj|intake regulates|nsubj|activity activity|amod|END_ENTITY	Glucokinase activity in the arcuate nucleus regulates glucose intake .
26264555	0	glucose	108,115	Glucokinase	0,11	glucose	Glucokinase	MESH:D005947	24385(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY cultured|advcl|concentration beneficial|xcomp|cultured beneficial|nsubj|activation activation|amod|END_ENTITY	Glucokinase activation is beneficial or toxic to cultured rat pancreatic islets depending on the prevailing glucose concentration .
8020491	0	glucose	53,60	Glucokinase	0,11	glucose	Glucokinase	MESH:D005947	24385(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY induces|dobj|uptake induces|nsubj|expression expression|amod|END_ENTITY	Glucokinase expression in rat hepatoma cells induces glucose uptake and is rate limiting in glucose utilization .
26041107	0	glucose	62,69	Glucose-dependent_insulinotropic_polypeptide	0,44	glucose	Glucose-dependent insulinotropic polypeptide	MESH:D005947	25040(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY induces|dobj|transport induces|nsubj|END_ENTITY	Glucose-dependent_insulinotropic_polypeptide directly induces glucose transport in rat skeletal muscle .
21562080	0	glucose	63,70	Glucose_transporter-1	0,21	glucose	Glucose transporter-1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	Glucose_transporter-1 in the hypothalamic glial cells mediates glucose sensing to regulate glucose production in vivo .
10229326	0	glucose	104,111	Glut-1	42,48	glucose	Glut-1	MESH:D005947	6513	Chemical	Gene	affinity|nmod|START_ENTITY associated|nmod|affinity associated|nsubjpass|N-glycosylation N-glycosylation|nmod|glucose_transporter-1 glucose_transporter-1|appos|END_ENTITY	N-glycosylation of glucose_transporter-1 -LRB- Glut-1 -RRB- is associated with increased transporter affinity for glucose in human leukemic cells .
11189940	0	glucose	22,29	Glut-1	15,21	glucose	Glut-1	MESH:D005947	6513	Chemical	Gene	START_ENTITY|nsubj|Correlation Correlation|nmod|END_ENTITY	Correlation of Glut-1 glucose transporter expression with .
11888207	0	glucose	105,112	Glut-1	98,104	glucose	Glut-1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Glucose uptake and lactate production in cells exposed to CoCl -LRB- 2 -RRB- and in cells overexpressing the Glut-1 glucose transporter .
18764953	0	glucose	38,45	Glut-1	59,65	glucose	Glut-1	MESH:D005947	6513	Chemical	Gene	expression|nmod|START_ENTITY transporters|nsubj|expression transporters|dobj|END_ENTITY	Immunohistochemical expression of the glucose transporters Glut-1 and Glut-3 in human malignant_melanomas and benign_melanocytic_lesions .
24578007	0	glucose	22,29	Glut-1	15,21	glucose	Glut-1	MESH:D005947	6513	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Correlation of Glut-1 glucose transporter expression with -LSB- -LRB- 18 -RRB- F -RSB- FDG uptake in non-small_cell_lung_cancer .
8221565	0	glucose	25,32	Glut-1	18,24	glucose	Glut-1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Overexpression of Glut-1 glucose transporter in human breast_cancer .
9359403	0	glucose	20,27	Glut-3	74,80	glucose	Glut-3	MESH:D005947	20527(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY transport|dep|affinity affinity|compound|END_ENTITY	Acute regulation of glucose transport in a monocyte-macrophage cell line : Glut-3 affinity for glucose is enhanced during the respiratory burst .
9359403	0	glucose	94,101	Glut-3	74,80	glucose	Glut-3	MESH:D005947	20527(Tax:10090)	Chemical	Gene	affinity|nmod|START_ENTITY affinity|compound|END_ENTITY	Acute regulation of glucose transport in a monocyte-macrophage cell line : Glut-3 affinity for glucose is enhanced during the respiratory burst .
10036168	0	glucose	142,149	Glut1	163,168	glucose	Glut1	MESH:D005947	6513	Chemical	Gene	transporters|compound|START_ENTITY transporters|dep|END_ENTITY	Simultaneous measurement of multiple mRNAs with a single control by quantitative competitive reverse transcriptase-polymerase chain reaction : glucose transporters Glut1 and Glut4 .
10196171	0	glucose	37,44	Glut1	31,36	glucose	Glut1	MESH:D005947	494763(Tax:8355)	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	Transmembrane segment 5 of the Glut1 glucose transporter is an amphipathic helix that forms part of the sugar permeation pathway .
10391130	0	glucose	28,35	Glut1	127,132	glucose	Glut1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY stimulation|nmod|transport Mechanism|nmod|stimulation Mechanism|dep|analysis analysis|nmod|END_ENTITY	Mechanism of stimulation of glucose transport in response to inhibition of oxidative phosphorylation : analysis with myc-tagged Glut1 .
10455140	0	glucose	54,61	Glut1	48,53	glucose	Glut1	MESH:D005947	494763(Tax:8355)	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	A conserved amino_acid motif -LRB- R-X-G-R-R -RRB- in the Glut1 glucose transporter is an important determinant of membrane topology .
10562431	0	glucose	47,54	Glut1	41,46	glucose	Glut1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	Association of stomatin -LRB- band 7.2 b -RRB- with Glut1 glucose transporter .
10708685	0	glucose	19,26	Glut1	73,78	glucose	Glut1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	utilization|compound|START_ENTITY utilization|acl|END_ENTITY	Increased cerebral glucose utilization and decreased glucose transporter Glut1 during chronic_hyperglycemia in rat brain .
11007796	0	glucose	144,151	Glut1	138,143	glucose	Glut1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	Glucose activates mitogen-activated protein kinase -LRB- extracellular_signal-regulated_kinase -RRB- through proline-rich_tyrosine_kinase-2 and the Glut1 glucose transporter .
11713254	0	glucose	50,57	Glut1	44,49	glucose	Glut1	MESH:D005947	494763(Tax:8355)	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	Analysis of transmembrane segment 10 of the Glut1 glucose transporter by cysteine-scanning mutagenesis and substituted cysteine accessibility .
12032147	0	glucose	11,18	Glut1	100,105	glucose	Glut1	MESH:D005947	494763(Tax:8355)	Chemical	Gene	transport|compound|START_ENTITY transport|acl|resulting resulting|nmod|mutation mutation|nmod|END_ENTITY	Changes in glucose transport and water permeability resulting from the T310I pathogenic mutation in Glut1 are consistent with two transport channels per monomer .
1325374	0	glucose	58,65	Glut1	52,57	glucose	Glut1	MESH:D005947	494763(Tax:8355)	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	The differential role of Cys-421 and Cys-429 of the Glut1 glucose transporter in transport inhibition by p-chloromercuribenzenesulfonic_acid -LRB- pCMBS -RRB- or cytochalasin B -LRB- CB -RRB- .
14642735	0	glucose	68,75	Glut1	62,67	glucose	Glut1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	The inhibitory effects of flavonoids and antiestrogens on the Glut1 glucose transporter in human erythrocytes .
14658600	0	glucose	34,41	Glut1	54,59	glucose	Glut1	MESH:D005947	6513	Chemical	Gene	expression|nmod|START_ENTITY transporter|nsubj|expression transporter|dobj|END_ENTITY	Immunohistochemical expression of glucose transporter Glut1 and cyclin_D1 in breast_carcinomas with negative lymph nodes .
15152356	0	glucose	8,15	Glut1	29,34	glucose	Glut1	MESH:D005947	6513	Chemical	Gene	deficiency|nummod|START_ENTITY deficiency|appos|END_ENTITY	-LSB- Type 1 glucose transporter -LRB- Glut1 -RRB- deficiency : manifestations of a hereditary_neurological_syndrome -RSB- .
15308632	0	glucose	37,44	Glut1	31,36	glucose	Glut1	MESH:D005947	494763(Tax:8355)	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	Transmembrane segment 3 of the Glut1 glucose transporter is an outer helix .
16172126	0	glucose	118,125	Glut1	112,117	glucose	Glut1	MESH:D005947	494763(Tax:8355)	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	Cysteine-scanning mutagenesis and substituted cysteine accessibility analysis of transmembrane segment 4 of the Glut1 glucose transporter .
16195374	0	glucose	47,54	Glut1	70,75	glucose	Glut1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Vitamin_C enters mitochondria via facilitative glucose transporter 1 -LRB- Glut1 -RRB- and confers mitochondrial protection against oxidative injury .
17020877	0	glucose	38,45	Glut1	32,37	glucose	Glut1	MESH:D005947	494763(Tax:8355)	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	Transmembrane segment 12 of the Glut1 glucose transporter is an outer helix and is not directly involved in the transport mechanism .
17301289	0	glucose	30,37	Glut1	97,102	glucose	Glut1	MESH:D005947	6513	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|regulation regulation|nmod|activity activity|amod|END_ENTITY	Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking .
17459098	0	glucose	27,34	Glut1	56,61	glucose	Glut1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY structure|nmod|transporter isoforms|nsubj|structure isoforms|ccomp|regulates regulates|nsubj|END_ENTITY	The intrinsic structure of glucose transporter isoforms Glut1 and Glut3 regulates their differential distribution to detergent-resistant membrane domains in nonpolarized mammalian cells .
18245775	0	glucose	37,44	Glut1	31,36	glucose	Glut1	MESH:D005947	494763(Tax:8355)	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	Transmembrane segment 6 of the Glut1 glucose transporter is an outer helix and contains amino_acid side chains essential for transport activity .
18796630	2	glucose	325,332	Glut1	319,324	glucose	Glut1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	Of all cell lineages , human erythrocytes express the highest level of the Glut1 glucose transporter with more than 200,000 molecules per cell .
19449892	0	glucose	85,92	Glut1	79,84	glucose	Glut1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	Model of the exofacial substrate-binding site and helical folding of the human Glut1 glucose transporter based on scanning mutagenesis .
26142142	0	glucose	23,30	Glut1	46,51	glucose	Glut1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY role|nmod|transporter study|nmod|role study|appos|END_ENTITY	A study of the role of glucose transporter 1 -LRB- Glut1 -RRB- in white_spot_syndrome_virus -LRB- WSSV -RRB- infection .
7595657	0	glucose	29,36	Glut1	23,28	glucose	Glut1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	High expression of the Glut1 glucose transporter in human brain_hemangioblastoma endothelium .
8051152	0	glucose	23,30	Glut1	17,22	glucose	Glut1	MESH:D005947	494763(Tax:8355)	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	Glutamine 161 of Glut1 glucose transporter is critical for transport activity and exofacial ligand binding .
8208668	0	glucose	34,41	Glut1	28,33	glucose	Glut1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	Developmental expression of Glut1 glucose transporter and c-fos genes in human placental cells .
8822374	0	glucose	63,70	Glut1	57,62	glucose	Glut1	MESH:D005947	6513	Chemical	Gene	START_ENTITY|nsubj|upregulation upregulation|nmod|END_ENTITY	Pathological upregulation of inner blood-retinal barrier Glut1 glucose transporter expression in diabetes_mellitus .
8852370	0	glucose	32,39	Glut1	26,31	glucose	Glut1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	Postnatal distribution of Glut1 glucose transporter and relative capillary density in blood-brain barrier structures and circumventricular organs during development .
8913969	0	glucose	6,13	Glut1	0,5	glucose	Glut1	MESH:D005947	6513	Chemical	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Glut1 glucose transporter activity in human brain_injury .
9040500	0	glucose	85,92	Glut1	16,21	glucose	Glut1	MESH:D005947	29483(Tax:10116)	Chemical	Gene	utilization|compound|START_ENTITY transporters|advcl|utilization transporters|nsubj|Distribution Distribution|nmod|glucose glucose|amod|END_ENTITY	Distribution of Glut1 glucose transporters in different brain structures compared to glucose utilization and capillary density of adult rat brains .
9059504	0	glucose	121,128	Glut1	115,120	glucose	Glut1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	Characterization of rat Glut4 glucose transporter expressed in the yeast Saccharomyces_cerevisiae : comparison with Glut1 glucose transporter .
9059504	0	glucose	30,37	Glut1	115,120	glucose	Glut1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY Characterization|nmod|transporter Characterization|dep|comparison comparison|nmod|transporter transporter|amod|END_ENTITY	Characterization of rat Glut4 glucose transporter expressed in the yeast Saccharomyces_cerevisiae : comparison with Glut1 glucose transporter .
9286080	0	glucose	59,66	Glut1	79,84	glucose	Glut1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY affinities|nmod|transporter END_ENTITY|nsubj|affinities	D-Glucose , forskolin and cytochalasin_B affinities for the glucose transporter Glut1 .
9428303	0	glucose	75,82	Glut1	69,74	glucose	Glut1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	Interictal seizure resections show two configurations of endothelial Glut1 glucose transporter in the human blood-brain barrier .
9519247	0	glucose	12,19	Glut1	43,48	glucose	Glut1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	densities|compound|START_ENTITY densities|dep|END_ENTITY	Increase of glucose transporter densities -LRB- Glut1 and Glut3 -RRB- during chronic administration of nicotine in rat brain .
9596411	0	glucose	6,13	Glut1	0,5	glucose	Glut1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	Glut1 glucose transporter in the primate choroid plexus endothelium .
9681995	0	glucose	20,27	Glut1	14,19	glucose	Glut1	MESH:D005947	6513	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	Activation of Glut1 glucose transporter in human erythrocytes .
9786919	0	glucose	106,113	Glut1	83,88	glucose	Glut1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY essential|nmod|transport essential|nsubj|END_ENTITY	Tryptophan 388 in putative transmembrane segment 10 of the rat glucose transporter Glut1 is essential for glucose transport .
9786919	0	glucose	63,70	Glut1	83,88	glucose	Glut1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	segment|nmod|START_ENTITY Tryptophan|nmod|segment END_ENTITY|amod|Tryptophan	Tryptophan 388 in putative transmembrane segment 10 of the rat glucose transporter Glut1 is essential for glucose transport .
24167319	0	glucose	96,103	Glut2	90,95	glucose	Glut2	MESH:D005947	20526(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Mouse embryonic stem cells established in physiological-glucose media express the high KM Glut2 glucose transporter expressed by normal embryos .
24167319	7	glucose	1023,1030	Glut2	1017,1022	glucose	Glut2	MESH:D005947	20526(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	Here we tested the hypothesis that low-glucose embryonic stem cells -LRB- LG-ESCs -RRB- isolated in physiological-glucose -LRB- 5.5 mmol/liter -RRB- media express a functional Glut2 glucose transporter .
8027028	0	glucose	24,31	Glut2	18,23	glucose	Glut2	MESH:D005947	6514	Chemical	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	A mutation in the Glut2 glucose transporter gene of a diabetic patient abolishes transport activity .
10412004	0	glucose	12,19	Glut3	45,50	glucose	Glut3	MESH:D005947	25551(Tax:10116)	Chemical	Gene	densities|compound|START_ENTITY densities|nmod|END_ENTITY	Increase in glucose transporter densities of Glut3 and decrease of glucose utilization in rat brain after one week of hypoglycemia .
21316350	0	glucose	81,88	Glut3	27,32	glucose	Glut3	MESH:D005947	20527(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY impair|dobj|uptake impair|nsubj|_ _|appos|END_ENTITY	Brain_glucose_transporter _ -LRB- Glut3 -RRB- _ haploinsufficiency does not impair mouse brain glucose uptake .
14511371	0	glucose	20,27	Glut4	73,78	glucose	Glut4	MESH:D005947	6517	Chemical	Gene	transport|compound|START_ENTITY involves|nsubj|transport involves|dobj|translocation translocation|amod|END_ENTITY	Arsenite stimulated glucose transport in 3T3-L1 adipocytes involves both Glut4 translocation and p38 MAPK activity .
1472028	0	glucose	41,48	Glut4	61,66	glucose	Glut4	MESH:D005947	6517	Chemical	Gene	transporter|compound|START_ENTITY translocation|nmod|transporter END_ENTITY|nsubj|translocation	Contraction-induced translocation of the glucose transporter Glut4 in isolated ventricular cardiomyocytes .
15772157	0	glucose	51,58	Glut4	45,50	glucose	Glut4	MESH:D005947	6517	Chemical	Gene	vesicles|compound|START_ENTITY vesicles|amod|END_ENTITY	Insulin-stimulated plasma membrane fusion of Glut4 glucose transporter-containing vesicles is regulated by phospholipase_D1 .
16227617	0	glucose	38,45	Glut4	32,37	glucose	Glut4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	Muscle-specific deletion of the Glut4 glucose transporter alters multiple regulatory steps in glycogen metabolism .
18305115	0	glucose	73,80	Glut4	67,72	glucose	Glut4	MESH:D005947	6517	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	Identification of amino_acid residues within the C terminus of the Glut4 glucose transporter that are essential for insulin-stimulated redistribution to the plasma membrane .
18796630	0	glucose	20,27	Glut4	14,19	glucose	Glut4	MESH:D005947	6517	Chemical	Gene	transporters|compound|START_ENTITY transporters|amod|END_ENTITY	The Glut1 and Glut4 glucose transporters are differentially expressed during perinatal and postnatal erythropoiesis .
1907567	0	glucose	22,29	Glut4	42,47	glucose	Glut4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY transporter|nsubj|regulation transporter|dobj|expression expression|amod|END_ENTITY	Inverse regulation of glucose transporter Glut4 and G-protein Gs mRNA expression in cardiac myocytes from insulin resistant rats .
20923959	8	glucose	1257,1264	Glut4	1075,1080	glucose	Glut4	MESH:D005947	403673(Tax:9615)	Chemical	Gene	uptake|compound|START_ENTITY assayed|nsubjpass|uptake assessed|parataxis|assayed assessed|nsubjpass|translocation translocation|amod|END_ENTITY	Glut4 translocation to the cell membrane was assessed using confocal microscopy analysis of GFP-Glut4 fusion-transfected cells and immunogold and electron microscopy on MC sections ; glucose uptake was assayed by 2-deoxyglucose -LRB- 2-DOG -RRB- uptake .
21252237	1	glucose	144,151	Glut4	221,226	glucose	Glut4	MESH:D005947	6517	Chemical	Gene	uptake|compound|START_ENTITY regulates|dobj|uptake regulates|nmod|effects effects|nmod|trafficking trafficking|nmod|END_ENTITY	Insulin regulates glucose uptake through effects on the trafficking of the glucose transporter Glut4 .
7814644	0	glucose	92,99	Glut4	18,23	glucose	Glut4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	disposal|compound|START_ENTITY increases|dobj|disposal increases|nsubj|Overexpression Overexpression|nmod|protein protein|amod|END_ENTITY	Overexpression of Glut4 protein in muscle increases basal and insulin-stimulated whole body glucose disposal in conscious mice .
7829503	0	glucose	106,113	Glut4	100,105	glucose	Glut4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	Skeletal muscle glucose transport and metabolism are enhanced in transgenic_mice overexpressing the Glut4 glucose transporter .
7829503	0	glucose	16,23	Glut4	100,105	glucose	Glut4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY enhanced|nsubjpass|transport enhanced|xcomp|overexpressing overexpressing|dobj|transporter transporter|amod|END_ENTITY	Skeletal muscle glucose transport and metabolism are enhanced in transgenic_mice overexpressing the Glut4 glucose transporter .
8253739	0	glucose	61,68	Glut4	55,60	glucose	Glut4	MESH:D005947	444033(Tax:8355)	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	Domains that confer intracellular sequestration of the Glut4 glucose transporter in Xenopus oocytes .
9059504	0	glucose	121,128	Glut4	24,29	glucose	Glut4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY comparison|nmod|transporter Characterization|dep|comparison Characterization|nmod|transporter transporter|compound|END_ENTITY	Characterization of rat Glut4 glucose transporter expressed in the yeast Saccharomyces_cerevisiae : comparison with Glut1 glucose transporter .
9059504	0	glucose	30,37	Glut4	24,29	glucose	Glut4	MESH:D005947	25139(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Characterization of rat Glut4 glucose transporter expressed in the yeast Saccharomyces_cerevisiae : comparison with Glut1 glucose transporter .
9339410	0	glucose	59,66	Glut4	80,85	glucose	Glut4	MESH:D005947	6517	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Quantitative methods for measuring the insulin-regulatable glucose transporter -LRB- Glut4 -RRB- .
1425430	0	glucose	75,82	Glut_1	53,59	glucose	Glut 1	MESH:D005947	6513	Chemical	Gene	transport|compound|START_ENTITY transporter|nmod|transport transporter|amod|END_ENTITY	Potential involvement of the carboxy-terminus of the Glut_1 transporter in glucose transport .
1874186	0	glucose	87,94	Glut_1	79,85	glucose	Glut 1	MESH:D005947	24778(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|distribution distribution|nmod|insulin-insensitive insulin-insensitive|appos|END_ENTITY	Developmental regulation of the distribution of rat brain insulin-insensitive -LRB- Glut_1 -RRB- glucose transporter .
7656423	0	glucose	43,50	Glut_1	64,70	glucose	Glut 1	MESH:D005947	20525(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Ontogenic expression of the erythroid-type glucose transporter -LRB- Glut_1 -RRB- in the telencephalon of the mouse : correlation to the tightening of the blood-brain barrier .
8051147	0	glucose	23,30	Glut_1	16,22	glucose	Glut 1	MESH:D005947	100125988(Tax:9986)	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	Topology of the Glut_1 glucose transporter deduced from glycosylation scanning mutagenesis .
8347668	0	glucose	52,59	Glut_1	157,163	glucose	Glut 1	MESH:D005947	6513	Chemical	Gene	activity|nmod|START_ENTITY pH|nmod|activity Glut_1|amod|pH Effects|nmod|Glut_1 Effects|dep|chromatography chromatography|nmod|liposomes liposomes|amod|END_ENTITY	Effects of pH on the activity of the human red cell glucose transporter Glut_1 : transport retention chromatography of D-glucose and L-glucose on immobilized Glut_1 liposomes .
8347668	0	glucose	52,59	Glut_1	72,78	glucose	Glut 1	MESH:D005947	6513	Chemical	Gene	activity|nmod|START_ENTITY pH|nmod|activity END_ENTITY|amod|pH	Effects of pH on the activity of the human red cell glucose transporter Glut_1 : transport retention chromatography of D-glucose and L-glucose on immobilized Glut_1 liposomes .
1505464	0	glucose	53,60	Glut_3	46,52	glucose	Glut 3	MESH:D005947	6515	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	Cellular localization and characterization of Glut_3 glucose transporter isoform in human brain .
8698853	0	glucose	38,45	Glut_4	19,25	glucose	Glut 4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY ablation|nmod|uptake ablation|nsubj|effects effects|nmod|END_ENTITY	Diverse effects of Glut_4 ablation on glucose uptake and glycogen synthesis in red and white skeletal muscle .
18701453	0	glucose	60,67	Glycogen_synthase_kinase_3beta	0,30	glucose	Glycogen synthase kinase 3beta	MESH:D005947	56637(Tax:10090)	Chemical	Gene	synthesis|amod|START_ENTITY regulator|nmod|synthesis regulator|nsubj|END_ENTITY	Glycogen_synthase_kinase_3beta is a novel regulator of high glucose - and high insulin-induced extracellular matrix protein synthesis in renal proximal tubular epithelial cells .
4181731	0	glucose	32,39	Growth-hormone	0,14	glucose	Growth-hormone	MESH:D005947	2688	Chemical	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Growth-hormone response to oral glucose in children with simple_obesity .
10474015	0	glucose	76,83	Growth_hormone	0,14	glucose	Growth hormone	MESH:D005947	2688	Chemical	Gene	homeostasis|compound|START_ENTITY effects|nmod|homeostasis treatment|dep|effects treatment|amod|END_ENTITY	Growth_hormone treatment of children with Prader-Willi_syndrome : effects on glucose and insulin homeostasis .
1117051	0	glucose	53,60	Growth_hormone	0,14	glucose	Growth hormone	MESH:D005947	2688	Chemical	Gene	administration|compound|START_ENTITY responses|nmod|administration responses|amod|END_ENTITY	Growth_hormone responses following double pulse oral glucose administration in various clinical states .
11407648	0	glucose	33,40	Growth_hormone	0,14	glucose	Growth hormone	MESH:D005947	2688	Chemical	Gene	responses|nmod|START_ENTITY responses|amod|END_ENTITY	Growth_hormone responses to oral glucose and intravenous thyrotropin-releasing_hormone in acromegalic patients treated by slow-release lanreotide .
15070919	0	glucose	48,55	Growth_hormone	0,14	glucose	Growth hormone	MESH:D005947	2688	Chemical	Gene	load|compound|START_ENTITY responses|nmod|load responses|compound|END_ENTITY	Growth_hormone and ghrelin responses to an oral glucose load in adolescent girls with anorexia_nervosa and controls .
15877290	0	glucose	40,47	Growth_hormone	0,14	glucose	Growth hormone	MESH:D005947	2688	Chemical	Gene	production|compound|START_ENTITY increases|dobj|production increases|nsubj|administration administration|amod|END_ENTITY	Growth_hormone administration increases glucose production by preventing the expected decrease in glycogenolysis seen with fasting in healthy volunteers .
16844028	0	glucose	98,105	Growth_hormone	0,14	glucose	Growth hormone	MESH:D005947	2688	Chemical	Gene	induced|nmod|START_ENTITY glutamine|dep|induced glutamine|nsubj|pre-treatment pre-treatment|amod|END_ENTITY	Growth_hormone pre-treatment combined with exogenous glutamine induced a postoperative shift from glucose to glutamine consumption in the gastrointestinal tract .
16912061	0	glucose	49,56	Growth_hormone	0,14	glucose	Growth hormone	MESH:D005947	81668(Tax:10116)	Chemical	Gene	utilization|compound|START_ENTITY modulate|dobj|utilization modulate|nsubj|END_ENTITY	Growth_hormone and IGF-I modulate local cerebral glucose utilization and ATP levels in a model of adult-onset growth_hormone deficiency .
17878248	0	glucose	41,48	Growth_hormone	0,14	glucose	Growth hormone	MESH:D005947	2688	Chemical	Gene	load|compound|START_ENTITY END_ENTITY|nmod|load	Growth_hormone suppression after an oral glucose load in children .
18171702	0	glucose	36,43	Growth_hormone	0,14	glucose	Growth hormone	MESH:D005947	2688	Chemical	Gene	test|compound|START_ENTITY response|nmod|test response|amod|END_ENTITY	Growth_hormone response during oral glucose tolerance test : the impact of assay method on the estimation of reference values in patients with acromegaly and in healthy controls , and the role of gender , age , and body mass index .
19082302	0	glucose	26,33	Growth_hormone	0,14	glucose	Growth hormone	MESH:D005947	2688	Chemical	Gene	overload|compound|START_ENTITY END_ENTITY|nmod|overload	Growth_hormone after oral glucose overload : revision of reference values in normal subjects .
19122000	0	glucose	29,36	Growth_hormone	0,14	glucose	Growth hormone	MESH:D005947	2688	Chemical	Gene	uptake|compound|START_ENTITY inhibition|nmod|uptake inhibition|amod|END_ENTITY	Growth_hormone inhibition of glucose uptake in adipocytes occurs without affecting GLUT4 translocation through an insulin receptor substrate-2-phosphatidylinositol 3-kinase-dependent pathway .
19468705	0	glucose	65,72	Growth_hormone	0,14	glucose	Growth hormone	MESH:D005947	14599(Tax:10090)	Chemical	Gene	tolerance|dep|START_ENTITY composition|appos|tolerance improves|nsubj|composition improves|advmod|END_ENTITY	Growth_hormone improves body composition , fasting blood_glucose , glucose tolerance and liver triacylglycerol in a mouse model of diet-induced obesity and type 2 diabetes .
19602554	0	glucose	48,55	Growth_hormone	0,14	glucose	Growth hormone	MESH:D005947	2688	Chemical	Gene	steroid|nmod|START_ENTITY steroid|nsubj|END_ENTITY	Growth_hormone and sex steroid effects on serum glucose , insulin , and lipid concentrations in healthy older women and men .
21054474	0	glucose	33,40	Growth_hormone	0,14	glucose	Growth hormone	MESH:D005947	2688	Chemical	Gene	load|compound|START_ENTITY nadir|nmod|load nadir|amod|END_ENTITY	Growth_hormone nadir during oral glucose load depends on waist circumference , gender and age : normative data in 231 healthy subjects .
2106529	0	glucose	33,40	Growth_hormone	0,14	glucose	Growth hormone	MESH:D005947	2688	Chemical	Gene	loading|compound|START_ENTITY responses|nmod|loading responses|amod|END_ENTITY	Growth_hormone responses to oral glucose loading measured by highly sensitive enzyme immunoassay in normal subjects and patients with glucose_intolerance and acromegaly .
21667426	0	glucose	60,67	Growth_hormone	0,14	glucose	Growth hormone	MESH:D005947	2688	Chemical	Gene	administration|compound|START_ENTITY secretion|nmod|administration secretion|advmod|END_ENTITY	Growth_hormone , ghrelin and peptide_YY secretion after oral glucose administration in healthy and obese women .
2189888	0	glucose	56,63	Growth_hormone	0,14	glucose	Growth hormone	MESH:D005947	2688	Chemical	Gene	carrier|compound|START_ENTITY requirement|nmod|carrier requirement|amod|END_ENTITY	Growth_hormone requirement for a normal human adipocyte glucose carrier function .
23794116	0	glucose	36,43	Growth_hormone	0,14	glucose	Growth hormone	MESH:D005947	2688	Chemical	Gene	load|compound|START_ENTITY add|nsubj|load values|advcl|add values|nsubj|END_ENTITY	Growth_hormone values after an oral glucose load do not add clinically useful information in patients with acromegaly on long-term somatostatin receptor ligand treatment .
26034073	0	glucose	155,162	Growth_hormone	0,14	glucose	Growth hormone	MESH:D005947	2688	Chemical	Gene	administration|compound|START_ENTITY fasting|advcl|administration stimulation|acl|fasting Amplification|nmod|stimulation Amplification|dep|signaling signaling|advmod|END_ENTITY	Growth_hormone signaling in human adipose and muscle tissue during `` feast and famine '' ; Amplification of exercise stimulation following fasting compared to glucose administration .
2671241	0	glucose	33,40	Growth_hormone	0,14	glucose	Growth hormone	MESH:D005947	81668(Tax:10116)	Chemical	Gene	output|compound|START_ENTITY increases|dobj|output increases|nsubj|END_ENTITY	Growth_hormone acutely increases glucose output by hepatocytes isolated from hypophysectomized rats .
394169	0	glucose	26,33	Growth_hormone	0,14	glucose	Growth hormone	MESH:D005947	81668(Tax:10116)	Chemical	Gene	oxidation|compound|START_ENTITY control|nmod|oxidation control|amod|END_ENTITY	Growth_hormone control of glucose oxidation pathways in hypophysectomized rats .
6391487	0	glucose	31,38	Growth_hormone	0,14	glucose	Growth hormone	MESH:D005947	2688	Chemical	Gene	utilization|compound|START_ENTITY alters|dobj|utilization alters|nsubj|END_ENTITY	Growth_hormone directly alters glucose utilization in 3T3 adipocytes .
704554	0	glucose	60,67	Growth_hormone	1,15	glucose	Growth hormone	MESH:D005947	2688	Chemical	Gene	load|compound|START_ENTITY level|nmod|load level|nsubj|END_ENTITY	-LSB- Growth_hormone level dynamics in acromegaly in response to glucose load and measured bicycle ergometry -RSB- .
7460820	0	glucose	30,37	Growth_hormone	0,14	glucose	Growth hormone	MESH:D005947	81668(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY stimulation|nmod|transport stimulation|amod|END_ENTITY	Growth_hormone stimulation of glucose transport in isolated rat hepatocyte suspensions and primary cultures .
7762644	0	glucose	23,30	Growth_hormone	0,14	glucose	Growth hormone	MESH:D005947	81668(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY GLUT-1|nsubj|transport reduces|xcomp|GLUT-1 reduces|nsubj|END_ENTITY	Growth_hormone reduces glucose transport but not GLUT-1 or GLUT-4 in adult and old rats .
9257116	0	glucose	52,59	Growth_hormone	0,14	glucose	Growth hormone	MESH:D005947	443329(Tax:9940)	Chemical	Gene	uptake|compound|START_ENTITY affect|dobj|uptake affect|nsubj|END_ENTITY	Growth_hormone does not affect non-insulin-mediated glucose uptake in sheep .
12727954	5	glucose	1522,1529	H-Ki	1477,1481	glucose	H-Ki	MESH:D005947	3098	Chemical	Gene	related|nmod|START_ENTITY related|nsubjpass|END_ENTITY	In the whole dataset , H-Ki was inversely related to fasting plasma glucose -LRB- correlation coefficient = -0.40 , P = 0.0018 -RRB- .
9743587	0	glucose	14,21	H-ras	0,5	glucose	H-ras	MESH:D005947	3265	Chemical	Gene	uptake|compound|START_ENTITY induces|dobj|uptake induces|nsubj|END_ENTITY	H-ras induces glucose uptake in brown adipocytes in an insulin - and phosphatidylinositol 3-kinase-independent manner .
12848931	0	glucose	18,25	HIF-1	40,45	glucose	HIF-1	MESH:D005947	3091	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|nmod|END_ENTITY	The regulation of glucose metabolism by HIF-1 mediates a neuroprotective response to amyloid_beta peptide .
23857671	0	glucose	29,36	HIF-1	56,61	glucose	HIF-1	MESH:D005947	3091	Chemical	Gene	metabolism|compound|START_ENTITY reprograms|dobj|metabolism reprograms|nmod|pathway pathway|compound|END_ENTITY	The CX3CL1/CX3CR1 reprograms glucose metabolism through HIF-1 pathway in pancreatic_adenocarcinoma .
26021979	0	glucose	5,12	HIF-1	41,46	glucose	HIF-1	MESH:D005947	3091	Chemical	Gene	insulin|compound|START_ENTITY affects|nsubj|insulin affects|dobj|END_ENTITY	High glucose and/or high insulin affects HIF-1 signaling by regulating AIP1 in human umbilical vein endothelial cells .
26021979	0	glucose	5,12	HIF-1	41,46	glucose	HIF-1	MESH:D005947	3091	Chemical	Gene	insulin|compound|START_ENTITY affects|nsubj|insulin affects|dobj|END_ENTITY	High glucose and/or high insulin affects HIF-1 signaling by regulating AIP1 in human umbilical vein endothelial cells .
22051049	0	glucose	44,51	HIF-1a	14,20	glucose	HIF-1a	MESH:D005947	15251(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY impairs|dobj|metabolism impairs|nsubj|Disruption Disruption|nmod|END_ENTITY	Disruption of HIF-1a in hepatocytes impairs glucose metabolism in diet-induced obesity mice .
24561986	0	glucose	24,31	HIF-1a	14,20	glucose	HIF-1a	MESH:D005947	3091	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	The effect of HIF-1a on glucose metabolism , growth and apoptosis of pancreatic_cancerous cells .
24664750	0	glucose	5,12	HIF-1a	39,45	glucose	HIF-1a	MESH:D005947	3091	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	High glucose activates ChREBP-mediated HIF-1a and VEGF expression in human RPE cells under normoxia .
25726501	0	glucose	48,55	HIF-1a	32,38	glucose	HIF-1a	MESH:D005947	29560(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY promotes|dobj|metabolism promotes|nsubj|Hypoxia Hypoxia|acl|preconditioning preconditioning|dobj|END_ENTITY	Hypoxia preconditioning induced HIF-1a promotes glucose metabolism and protects mitochondria in liver I/R injury .
20540786	0	glucose	82,89	HIF1A	143,148	glucose	HIF1A	MESH:D005947	3091	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The association of 18F-deoxyglucose -LRB- FDG -RRB- uptake of PET with polymorphisms in the glucose transporter gene -LRB- SLC2A1 -RRB- and hypoxia-related genes -LRB- HIF1A , VEGFA , APEX1 -RRB- in non-small_cell_lung_cancer .
25012504	0	glucose	32,39	HIF1a	55,60	glucose	HIF1a	MESH:D005947	15251(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|nmod|modulation modulation|amod|END_ENTITY	Tumor suppressor WWOX regulates glucose metabolism via HIF1a modulation .
26743088	0	glucose	14,21	HIF1a	55,60	glucose	HIF1a	MESH:D005947	3091	Chemical	Gene	Regulation|nmod|START_ENTITY metabolism|nsubj|Regulation metabolism|nmod|END_ENTITY	Regulation of glucose metabolism by p62/SQSTM1 through HIF1a .
26261550	0	glucose	99,106	HMGB1	0,5	glucose	HMGB1	MESH:D005947	3146	Chemical	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	HMGB1 is activated in type_2_diabetes_mellitus patients and in mesangial cells in response to high glucose .
10049364	0	glucose	72,79	HNF3alpha	54,63	glucose	HNF3alpha	MESH:D005947	15375(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY affects|dobj|homeostasis affects|nsubj|END_ENTITY	Inactivation of the winged helix transcription factor HNF3alpha affects glucose homeostasis and islet glucagon gene expression in vivo .
26967002	0	glucose	81,88	HSPA1A	90,96	glucose	HSPA1A	MESH:D005947	282254(Tax:9913)	Chemical	Gene	Effects|appos|START_ENTITY END_ENTITY|nsubj|Effects	Effects of transport distance , lairage time and stunning efficiency on cortisol , glucose , HSPA1A and how they relate with meat quality in cattle .
26654890	0	glucose	33,40	HT7	26,29	glucose	HT7	MESH:D005947	25246(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	Effects of acupuncture at HT7 on glucose metabolism in a rat model of Alzheimer 's _ disease : an 18F-FDG-PET study .
12220226	0	glucose	84,91	HXT1	79,83	glucose	HXT1	MESH:D005947	856494(Tax:4932)	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Active Snf1 protein kinase inhibits expression of the Saccharomyces_cerevisiae HXT1 glucose transporter gene .
15014083	0	glucose	36,43	HXT1	18,22	glucose	HXT1	MESH:D005947	856494(Tax:4932)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Expression of the HXT1 low affinity glucose transporter requires the coordinated activities of the HOG and glucose signalling pathways .
15099735	0	glucose	2,9	HXT1	69,73	glucose	HXT1	MESH:D005947	856494(Tax:4932)	Chemical	Gene	element|compound|START_ENTITY element|nmod|gene gene|compound|END_ENTITY	A glucose response element from the S. _ cerevisiae hexose transporter HXT1 gene is sensitive to glucose in human fibroblasts .
15099735	0	glucose	95,102	HXT1	69,73	glucose	HXT1	MESH:D005947	856494(Tax:4932)	Chemical	Gene	sensitive|nmod|START_ENTITY sensitive|nsubj|element element|nmod|gene gene|compound|END_ENTITY	A glucose response element from the S. _ cerevisiae hexose transporter HXT1 gene is sensitive to glucose in human fibroblasts .
15849787	0	glucose	105,112	HXT1	78,82	glucose	HXT1	MESH:D005947	856494(Tax:4932)	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|appos|transporter	TOR kinase pathway and 14-3-3 proteins regulate glucose-induced expression of HXT1 , a yeast low-affinity glucose transporter .
24000146	0	glucose	8,15	Harvey-ras	30,40	glucose	Harvey-ras	MESH:D005947	3265	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|nmod|END_ENTITY	Altered glucose metabolism in Harvey-ras transformed MCF10A cells .
7358227	0	glucose	31,38	HbA1	0,4	glucose	HbA1	MESH:D005947	3039	Chemical	Gene	tolerance|compound|START_ENTITY subjects|nmod|tolerance END_ENTITY|nmod|subjects	HbA1 in subjects with abnormal glucose tolerance but normal fasting_plasma_glucose .
22879979	0	glucose	65,72	Heme_oxygenase-1	0,16	glucose	Heme oxygenase-1	MESH:D005947	3162	Chemical	Gene	protects|nmod|START_ENTITY protects|nsubj|END_ENTITY	Heme_oxygenase-1 protects retinal endothelial cells against high glucose - and oxidative/nitrosative stress-induced toxicity .
2566971	0	glucose	43,50	Hep	24,27	glucose	Hep	MESH:D005947	728489	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Stu I RFLP at the human Hep G2/erythrocyte glucose transporter -LRB- GLUT -RRB- gene locus .
15983219	0	glucose	52,59	Heparanase-1	0,12	glucose	Heparanase-1	MESH:D005947	10855	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Heparanase-1 gene expression and regulation by high glucose in renal epithelial cells : a potential role in the pathogenesis of proteinuria in diabetic patients .
11073928	0	glucose	33,40	Hexokinase	0,10	glucose	Hexokinase	MESH:D005947	851167(Tax:4932)	Chemical	Gene	transport|compound|START_ENTITY kinetics|nmod|transport regulates|dobj|kinetics regulates|nsubj|END_ENTITY	Hexokinase regulates kinetics of glucose transport and expression of genes encoding hexose transporters in Saccharomyces_cerevisiae .
26865637	0	glucose	33,40	Hexokinase_2	0,12	glucose	Hexokinase 2	MESH:D005947	852639(Tax:4932)	Chemical	Gene	sensor|compound|START_ENTITY sensor|nsubj|END_ENTITY	Hexokinase_2 is an intracellular glucose sensor of yeast cells that maintains the structure and activity of Mig1 repressor complex .
20141841	0	glucose	40,47	Hif1alpha	64,73	glucose	Hif1alpha	MESH:D005947	15251(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY homeostasis|nmod|END_ENTITY	The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha .
22991226	0	glucose	32,39	Histone_deacetylase_5	0,21	glucose	Histone deacetylase 5	MESH:D005947	10014	Chemical	Gene	uptake|compound|START_ENTITY regulates|dobj|uptake regulates|nsubj|END_ENTITY	Histone_deacetylase_5 regulates glucose uptake and insulin action in muscle cells .
12702270	0	glucose	20,27	Hxt1	161,165	glucose	Hxt1	MESH:D005947	856494(Tax:4932)	Chemical	Gene	transport|compound|START_ENTITY transport|nmod|Saccharomyces_cerevisiae Saccharomyces_cerevisiae|nmod|END_ENTITY	Characterisation of glucose transport in Saccharomyces_cerevisiae with plasma membrane vesicles -LRB- countertransport -RRB- and intact cells -LRB- initial uptake -RRB- with single Hxt1 , Hxt2 , Hxt3 , Hxt4 , Hxt6 , Hxt7 or Gal2 transporters .
15128737	0	glucose	82,89	Hxt2	103,107	glucose	Hxt2	MESH:D005947	855023(Tax:4932)	Chemical	Gene	transport|compound|START_ENTITY transport|nmod|END_ENTITY	Comprehensive chimeric analysis of amino_acid residues critical for high affinity glucose transport by Hxt2 of Saccharomyces_cerevisiae .
12702277	0	glucose	65,72	Hxt5	60,64	glucose	Hxt5	MESH:D005947	856496(Tax:4932)	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	Determination of in vivo kinetics of the starvation-induced Hxt5 glucose transporter of Saccharomyces_cerevisiae .
6247781	0	glucose	51,58	IAP	37,40	glucose	IAP	MESH:D005947	29364(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of islet-activating protein -LRB- IAP -RRB- on blood glucose and plasma insulin in healthy volunteers -LRB- phase 1 studies -RRB- .
10341286	0	glucose	23,30	IAPP	0,4	glucose	IAPP	MESH:D005947	3375	Chemical	Gene	homeostasis|compound|START_ENTITY END_ENTITY|nmod|homeostasis	IAPP as a regulator of glucose homeostasis and pancreatic hormone secretion -LRB- review -RRB- .
10475094	0	glucose	5,12	ICAM-1	104,110	glucose	ICAM-1	MESH:D005947	3383	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|adhesion adhesion|acl|valvular valvular|dobj|cells cells|nmod|mechanism mechanism|nmod|END_ENTITY	High glucose induces enhanced monocyte adhesion to valvular endothelial cells via a mechanism involving ICAM-1 , VCAM-1 and CD18 .
11205865	4	glucose	672,679	ICAM-1	632,638	glucose	ICAM-1	MESH:D005947	3383	Chemical	Gene	induced|nmod|START_ENTITY mRNA|acl|induced mRNA|compound|END_ENTITY	Staurosporine -LRB- 10 nM -RRB- , epalrestat -LRB- 10 microM -RRB- suppressed the expression of ICAM-1 mRNA and protein induced by high glucose to variable extents .
15304054	0	glucose	18,25	ICAM-1	35,41	glucose	ICAM-1	MESH:D005947	3383	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Intermittent high glucose enhances ICAM-1 , VCAM-1 , E-selectin and interleukin-6 expression in human umbilical endothelial cells in culture : the role of poly -LRB- ADP-ribose -RRB- _ polymerase .
16285992	0	glucose	18,25	ICAM-1	35,41	glucose	ICAM-1	MESH:D005947	3383	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Intermittent high glucose enhances ICAM-1 , VCAM-1 and E-selectin expression in human umbilical vein endothelial cells in culture : the distinct role of protein kinase C and mitochondrial superoxide production .
23111892	0	glucose	97,104	ICAM-1	40,46	glucose	ICAM-1	MESH:D005947	3383	Chemical	Gene	induced|nmod|START_ENTITY adhesion|acl|induced adhesion|compound|END_ENTITY	Sarpogrelate inhibits the expression of ICAM-1 and monocyte-endothelial adhesion induced by high glucose in human endothelial cells .
8637395	0	glucose	138,145	ICAM-1	50,56	glucose	ICAM-1	MESH:D005947	3383	Chemical	Gene	medium|compound|START_ENTITY exposed|nmod|medium cells|acl|exposed adhesion|nmod|cells adhesion|dobj|1 1|appos|END_ENTITY	Expression of intercellular adhesion molecules 1 -LRB- ICAM-1 -RRB- via an osmotic effect in human umbilical vein endothelial cells exposed to high glucose medium .
18793116	0	glucose	17,24	IGF-1	8,13	glucose	IGF-1	MESH:D005947	3479	Chemical	Gene	regulation|compound|START_ENTITY Role|nmod|regulation Role|nmod|END_ENTITY	Role of IGF-1 in glucose regulation and cardiovascular_disease .
26550421	0	glucose	59,66	IGF-1	91,96	glucose	IGF-1	MESH:D005947	3479	Chemical	Gene	induced|nmod|START_ENTITY induced|nmod|END_ENTITY	miR-29a promotes myocardial cell apoptosis induced by high glucose through down-regulating IGF-1 .
10905488	0	glucose	59,66	IGF-I	0,5	glucose	IGF-I	MESH:D005947	3479	Chemical	Gene	metabolism|compound|START_ENTITY effects|nmod|metabolism treatment|dep|effects treatment|amod|END_ENTITY	IGF-I treatment in adults with type 1 diabetes : effects on glucose and protein metabolism in the fasting state and during a hyperinsulinemic-euglycemic amino_acid clamp .
11139769	0	glucose	69,76	IGF-I	9,14	glucose	IGF-I	MESH:D005947	610255(Tax:9615)	Chemical	Gene	metabolism|compound|START_ENTITY regulating|dobj|metabolism insulin|acl|regulating advantage|nmod|insulin has|dobj|advantage has|nsubj|END_ENTITY	Low-dose IGF-I has no selective advantage over insulin in regulating glucose metabolism in hyperglycemic depancreatized dogs .
12050267	0	glucose	64,71	IGF-I	14,19	glucose	IGF-I	MESH:D005947	3479	Chemical	Gene	test|compound|START_ENTITY END_ENTITY|nmod|test	Placental GH , IGF-I , IGF-binding_protein-1 , and leptin during a glucose challenge test in pregnant women : relation with maternal body weight , glucose_tolerance , and birth weight .
12703844	0	glucose	151,158	IGF-I	67,72	glucose	IGF-I	MESH:D005947	3479	Chemical	Gene	disposal|compound|START_ENTITY relationships|nmod|disposal effects|dep|relationships effects|nmod|training training|nmod|insulin-like_growth_factor_I insulin-like_growth_factor_I|appos|END_ENTITY	The effects of intensive training on insulin-like_growth_factor_I -LRB- IGF-I -RRB- and IGF_binding_proteins_1_and_3 in competitive cyclists : relationships with glucose disposal .
12870155	0	glucose	162,169	IGF-I	46,51	glucose	IGF-I	MESH:D005947	3479	Chemical	Gene	disposal|compound|START_ENTITY relationship|nmod|disposal levels|dep|relationship levels|nmod|factor-I factor-I|appos|END_ENTITY	Serum levels of insulin-like growth factor-I -LRB- IGF-I -RRB- , and IGF-binding_proteins-1_and _ -3 in middle-aged and young athletes versus sedentary men : relationship with glucose disposal .
15616244	0	glucose	121,128	IGF-I	24,29	glucose	IGF-I	MESH:D005947	3479	Chemical	Gene	tolerance|compound|START_ENTITY degrees|nmod|tolerance associated|nmod|degrees associated|nsubjpass|concentration concentration|nmod|END_ENTITY	Plasma concentration of IGF-I is independently associated with insulin sensitivity in subjects with different degrees of glucose tolerance .
16868142	0	glucose	68,75	IGF-I	21,26	glucose	IGF-I	MESH:D005947	3479	Chemical	Gene	tolerance|compound|START_ENTITY END_ENTITY|nmod|tolerance	Changes in bioactive IGF-I and IGF-binding_protein-1 during an oral glucose tolerance test in patients with liver_cirrhosis .
1770040	0	glucose	48,55	IGF-I	30,35	glucose	IGF-I	MESH:D005947	3479	Chemical	Gene	uptake|compound|START_ENTITY stimulates|dobj|uptake stimulates|nsubj|Insulin-like_growth_factor_I Insulin-like_growth_factor_I|appos|END_ENTITY	Insulin-like_growth_factor_I -LRB- IGF-I -RRB- stimulates glucose and amino_acid uptake in cultured glomerular mesangial cells .
19902049	0	glucose	100,107	IGF-I	49,54	glucose	IGF-I	MESH:D005947	3479	Chemical	Gene	tolerance|compound|START_ENTITY degrees|nmod|tolerance subjects|nmod|degrees serum|nmod|subjects serum|dobj|levels levels|amod|END_ENTITY	Study of insulin resistance in relation to serum IGF-I levels in subjects with different degrees of glucose tolerance .
20237304	9	glucose	1540,1547	IGF-I	1594,1599	glucose	IGF-I	MESH:D005947	100136741(Tax:8022)	Chemical	Gene	uptake|compound|START_ENTITY stimulation|nmod|uptake inhibited|dobj|stimulation inhibited|advcl|suggesting suggesting|ccomp|plays plays|nsubj|END_ENTITY	IGF-I was more potent in stimulating glucose uptake than insulin , and PD98059 and wortmannin inhibited the stimulation of glucose uptake by this growth factor , suggesting that IGF-I plays an important metabolic role in trout adipocytes .
2166697	0	glucose	18,25	IGF-I	0,5	glucose	IGF-I	MESH:D005947	3479	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|dep|transport	IGF-I -- stimulated glucose transport in human skeletal muscle and IGF-I resistance in obesity and NIDDM .
22023218	0	glucose	21,28	IGF-I	0,5	glucose	IGF-I	MESH:D005947	16000(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY contributes|nmod|homeostasis contributes|nsubj|END_ENTITY	IGF-I contributes to glucose homeostasis in the Berlin_Fat_Mouse_Inbred line .
24486085	0	glucose	122,129	IGF-I	50,55	glucose	IGF-I	MESH:D005947	100008668(Tax:9986)	Chemical	Gene	uptake|nmod|START_ENTITY stimulation|nmod|uptake END_ENTITY|dobj|stimulation	Green tea -LRB- - -RRB- - epigallocatechin_gallate suppresses IGF-I and IGF-II stimulation of 3T3-L1 adipocyte glucose uptake via the glucose transporter 4 , but not glucose transporter 1 pathway .
24486085	0	glucose	99,106	IGF-I	50,55	glucose	IGF-I	MESH:D005947	100008668(Tax:9986)	Chemical	Gene	uptake|compound|START_ENTITY stimulation|nmod|uptake END_ENTITY|dobj|stimulation	Green tea -LRB- - -RRB- - epigallocatechin_gallate suppresses IGF-I and IGF-II stimulation of 3T3-L1 adipocyte glucose uptake via the glucose transporter 4 , but not glucose transporter 1 pathway .
24615360	0	glucose	22,29	IGF-I	153,158	glucose	IGF-I	MESH:D005947	16000(Tax:10090)	Chemical	Gene	influence|nmod|START_ENTITY influence|dep|comparison comparison|nmod|effect effect|amod|END_ENTITY	The influence of high glucose and high insulin on mechanisms controlling cell cycle progression and arrest in mouse C2C12 myoblasts : the comparison with IGF-I effect .
25157747	0	glucose	38,45	IGF-I	91,96	glucose	IGF-I	MESH:D005947	3479	Chemical	Gene	transporter|compound|START_ENTITY GLUT1|dobj|transporter GLUT1|nmod|insulin-like_growth_factor_I insulin-like_growth_factor_I|appos|END_ENTITY	Regulation of human trophoblast GLUT1 glucose transporter by insulin-like_growth_factor_I -LRB- IGF-I -RRB- .
3909152	5	glucose	738,745	IGF-I	703,708	glucose	IGF-I	MESH:D005947	3479	Chemical	Gene	oxidation|compound|START_ENTITY stimulated|dobj|oxidation stimulated|nsubj|END_ENTITY	After 4 hr of incubation , IGF-I from human plasma stimulated glucose oxidation in a dose-related manner , producing a 10-fold increase at 50 ng/ml .
7575481	0	glucose	65,72	IGF-I	42,47	glucose	IGF-I	MESH:D005947	378699(Tax:8355)	Chemical	Gene	translocation|compound|START_ENTITY stimulate|dobj|translocation stimulate|dep|END_ENTITY	Insulin and insulin-like growth factor I -LRB- IGF-I -RRB- stimulate GLUT4 glucose transporter translocation in Xenopus oocytes .
7656918	0	glucose	52,59	IGF-I	31,36	glucose	IGF-I	MESH:D005947	3479	Chemical	Gene	metabolism|compound|START_ENTITY comparison|nmod|metabolism comparison|nmod|effects effects|nmod|END_ENTITY	A comparison of the effects of IGF-I and insulin on glucose metabolism , fat metabolism and the cardiovascular system in normal human volunteers .
7943226	0	glucose	48,55	IGF-I	23,28	glucose	IGF-I	MESH:D005947	24482(Tax:10116)	Chemical	Gene	system|compound|START_ENTITY effects|nmod|system effects|nmod|END_ENTITY	Comparative effects of IGF-I and insulin on the glucose transporter system in rat muscle .
8045959	7	glucose	1227,1234	IGF-I	1158,1163	glucose	IGF-I	MESH:D005947	3479	Chemical	Gene	concentrations|compound|START_ENTITY control|dobj|concentrations appeared|xcomp|control appeared|nmod|sc sc|acl|administered administered|advmod|END_ENTITY	With sc administered IGF-I -LRB- up to 10 mg twice daily -RRB- , insulin appeared to control patient glucose concentrations , but severe insulin resistance returned within 72 h of discontinuing IGF-I therapy .
8722694	0	glucose	27,34	IGF-I	0,5	glucose	IGF-I	MESH:D005947	16000(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY regulate|dobj|transport regulate|nsubj|END_ENTITY	IGF-I and insulin regulate glucose transport in mouse blastocysts via IGF-I_receptor .
8760095	0	glucose	32,39	IGF-I	23,28	glucose	IGF-I	MESH:D005947	3479	Chemical	Gene	circulating|nmod|START_ENTITY circulating|dobj|END_ENTITY	Effects of circulating IGF-I on glucose and amino_acid kinetics in the ovine fetus .
8821099	0	glucose	24,31	IGF-I	0,5	glucose	IGF-I	MESH:D005947	24482(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY stimulates|dobj|uptake stimulates|nsubj|END_ENTITY	IGF-I stimulates muscle glucose uptake during sepsis .
9361347	0	glucose	71,78	IGF-I	61,66	glucose	IGF-I	MESH:D005947	24482(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY block|nmod|uptake block|dobj|effects effects|appos|END_ENTITY	Cytokines block the effects of insulin-like_growth_factor-I -LRB- IGF-I -RRB- on glucose uptake and lactate production in skeletal muscle but do not influence IGF-I-induced changes in protein turnover .
9688638	0	glucose	62,69	IGF-I	0,5	glucose	IGF-I	MESH:D005947	3479	Chemical	Gene	uptake|compound|START_ENTITY forearm|nmod|uptake forearm|nsubj|increases increases|amod|END_ENTITY	IGF-I increases forearm blood flow without increasing forearm glucose uptake .
11317665	0	glucose	86,93	IGFBP-1	72,79	glucose	IGFBP-1	MESH:D005947	3484	Chemical	Gene	tolerance|compound|START_ENTITY END_ENTITY|nmod|tolerance	Close relation of fasting insulin-like_growth_factor_binding_protein-1 -LRB- IGFBP-1 -RRB- with glucose tolerance and cardiovascular risk in two populations .
1689652	0	glucose	14,21	IGFBP-1	101,108	glucose	IGFBP-1	MESH:D005947	3484	Chemical	Gene	Inhibitors|nmod|START_ENTITY uptake|nsubj|Inhibitors uptake|xcomp|stimulate stimulate|dobj|production production|nmod|insulin-like_growth_factor-binding_protein insulin-like_growth_factor-binding_protein|appos|END_ENTITY	Inhibitors of glucose uptake stimulate the production of insulin-like_growth_factor-binding_protein -LRB- IGFBP-1 -RRB- by human fetal liver .
19463807	0	glucose	126,133	IGFBP-1	84,91	glucose	IGFBP-1	MESH:D005947	3484	Chemical	Gene	tolerance|compound|START_ENTITY variation|nmod|tolerance variation|nmod|insulin-like_growth_factor_binding_protein-1 insulin-like_growth_factor_binding_protein-1|appos|END_ENTITY	Biological variation in fasting serum insulin-like_growth_factor_binding_protein-1 -LRB- IGFBP-1 -RRB- among individuals with a varying glucose tolerance .
23548151	0	glucose	134,141	IGFBP-1	86,93	glucose	IGFBP-1	MESH:D005947	3484	Chemical	Gene	tolerance|compound|START_ENTITY degrees|nmod|tolerance individuals|nmod|degrees change|nmod|individuals change|dobj|values values|nmod|END_ENTITY	Reference change values for insulin and insulin-like_growth_factor_binding_protein-1 -LRB- IGFBP-1 -RRB- in individuals with varying degrees of glucose tolerance .
7516850	5	glucose	858,865	IGFBP-1	806,813	glucose	IGFBP-1	MESH:D005947	3484	Chemical	Gene	hormones|compound|START_ENTITY similar|nmod|hormones manner|amod|similar regulated|nmod|manner regulated|nsubjpass|END_ENTITY	In contrast , IGFBP-1 is acutely regulated in a manner similar to glucose counterregulatory hormones .
9170816	12	glucose	1708,1715	IGFBP-1	1745,1752	glucose	IGFBP-1	MESH:D005947	3484	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|nmod|END_ENTITY	Thus , glucose stimulates the production of IGFBP-1 in the maternal circulation of a placenta in vitro .
10597881	0	glucose	42,49	IGFBP-3	17,24	glucose	IGFBP-3	MESH:D005947	3486	Chemical	Gene	test|compound|START_ENTITY response|nmod|test response|compound|END_ENTITY	GH , IGFBP-1 , and IGFBP-3 response to oral glucose tolerance test in perimenopausal women : no influence of body mass index .
10744662	0	glucose	45,52	IHG-2	0,5	glucose	IHG-2	MESH:D005947	26585	Chemical	Gene	induced|nmod|START_ENTITY gene|acl|induced END_ENTITY|appos|gene	IHG-2 , a mesangial cell gene induced by high glucose , is human gremlin .
17426109	0	glucose	5,12	IL-1beta	21,29	glucose	IL-1beta	MESH:D005947	3553	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	High glucose induces IL-1beta expression in human monocytes : mechanistic insights .
9211864	6	glucose	1672,1679	IL-3	1657,1661	glucose	IL-3	MESH:D005947	481497(Tax:9615)	Chemical	Gene	uptake|compound|START_ENTITY regulates|dobj|uptake regulates|nsubj|END_ENTITY	These results demonstrate that IL-3 regulates glucose uptake by modulating the intrinsic transporting ability of glucose transporters .
26869278	13	glucose	1621,1628	IL-6	1642,1646	glucose	VEGF	MESH:D005947	7422	Chemical	Gene	up-regulates|compound|START_ENTITY END_ENTITY|nsubj|up-regulates	CONCLUSION : The present study might provide evidence that high glucose up-regulates IL-6 synthesis in Met-5A cells , to some extent , depending on its osmolality and that IL-6 trans-signaling could induce VEGF synthesis partly dependent on the JAK/STAT3 pathway .
10627287	0	glucose	60,67	INS-1	98,103	glucose	INS-1	MESH:D005947	2305	Chemical	Gene	peptides|compound|START_ENTITY peptides|nmod|beta-cells beta-cells|compound|END_ENTITY	Essentiality of intron control in the induction of c-fos by glucose and glucoincretin peptides in INS-1 beta-cells .
11145586	0	glucose	38,45	INS-1	152,157	glucose	INS-1	MESH:D005947	2305	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Free fatty_acid-induced inhibition of glucose and insulin-like_growth_factor_I-induced deoxyribonucleic acid synthesis in the pancreatic beta-cell line INS-1 .
12037718	0	glucose	80,87	INS-1	27,32	glucose	INS-1	MESH:D005947	2305	Chemical	Gene	metabolite|compound|START_ENTITY caused|nmod|metabolite function|acl|caused evidence|nmod|function desensitization|dep|evidence desensitization|nmod|cells cells|compound|END_ENTITY	Glucose desensitization in INS-1 cells : evidence of impaired function caused by glucose metabolite -LRB- s -RRB- rather than by the glucose molecule per se .
12369712	0	glucose	88,95	INS-1	143,148	glucose	INS-1	MESH:D005947	2305	Chemical	Gene	Role|nmod|START_ENTITY Role|acl|coupled coupled|dobj|receptors receptors|nmod|cells cells|compound|END_ENTITY	Role of protein_kinase_C , PI3-kinase and tyrosine kinase in activation of MAP kinase by glucose and agonists of G-protein coupled receptors in INS-1 cells .
15072548	0	glucose	15,22	INS-1	60,65	glucose	INS-1	MESH:D005947	24505(Tax:10116)	Chemical	Gene	levels|amod|START_ENTITY reduces|dobj|levels reduces|nmod|beta-cells beta-cells|compound|END_ENTITY	Leptin reduces glucose transport and cellular ATP levels in INS-1 beta-cells .
15572344	0	glucose	57,64	INS-1	106,111	glucose	INS-1	MESH:D005947	2305	Chemical	Gene	kinases|compound|START_ENTITY regulated|nmod|kinases regulated|nmod|cells cells|compound|END_ENTITY	A highly Ca2 + - sensitive pool of granules is regulated by glucose and protein kinases in insulin-secreting INS-1 cells .
15650027	0	glucose	9,16	INS-1	68,73	glucose	INS-1	MESH:D005947	2305	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|nmod|beta-cells beta-cells|amod|pancreatic pancreatic|amod|END_ENTITY	Elevated glucose attenuates human insulin gene promoter activity in INS-1 pancreatic beta-cells via reduced nuclear factor binding to the A5/core and Z element .
20965838	0	glucose	106,113	INS-1	65,70	glucose	INS-1	MESH:D005947	2305	Chemical	Gene	-RSB-|compound|START_ENTITY exposed|nmod|-RSB- exposed|nsubj|Effects Effects|nmod|cells cells|amod|related related|nmod|apoptosis apoptosis|nmod|END_ENTITY	-LSB- Effects of heme_oxygenase-1 on proteins related to apoptosis in INS-1 cells exposed to intermittent high glucose -RSB- .
21430707	0	glucose	44,51	INS-1	25,30	glucose	INS-1	MESH:D005947	2305	Chemical	Gene	death|amod|START_ENTITY b-cells|nmod|death b-cells|nsubj|Protection Protection|nmod|END_ENTITY	Protection of pancreatic INS-1 b-cells from glucose - and fructose-induced cell death by inhibiting mitochondrial permeability transition with cyclosporin_A or metformin .
21515469	0	glucose	25,32	INS-1	110,115	glucose	INS-1	MESH:D005947	24505(Tax:10116)	Chemical	Gene	exposure|compound|START_ENTITY memory|nmod|exposure mediated|nsubjpass|memory mediated|nmod|species species|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Cellular memory of high glucose exposure in normoglycemia is probably mediated by reactive oxygen species in INS-1 cells -RSB- .
21747833	0	glucose	18,25	INS-1	48,53	glucose	INS-1	MESH:D005947	2305	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|apoptosis apoptosis|nmod|cells cells|compound|END_ENTITY	Intermittent high glucose enhances apoptosis in INS-1 cells .
22579214	0	glucose	39,46	INS-1	12,17	glucose	INS-1	MESH:D005947	2305	Chemical	Gene	fluctuation|compound|START_ENTITY apoptosis|nmod|fluctuation apoptosis|compound|END_ENTITY	Increase of INS-1 cell apoptosis under glucose fluctuation and the involvement of FOXO-SIRT pathway .
23426361	0	glucose	23,30	INS-1	50,55	glucose	INS-1	MESH:D005947	2305	Chemical	Gene	START_ENTITY|nmod|line line|amod|END_ENTITY	Metabolome response to glucose in the b-cell line INS-1 832/13 .
24356960	0	glucose	13,20	INS-1	141,146	glucose	INS-1	MESH:D005947	2305	Chemical	Gene	affect|nsubj|START_ENTITY affect|nmod|cells cells|amod|END_ENTITY	Chronic high glucose and pyruvate levels differentially affect mitochondrial bioenergetics and fuel-stimulated insulin secretion from clonal INS-1 832/13 cells .
24859892	0	glucose	91,98	INS-1	48,53	glucose	INS-1	MESH:D005947	2305	Chemical	Gene	concentrations|compound|START_ENTITY inhibited|nmod|concentrations inhibited|nsubj|activity activity|nmod|cells cells|compound|END_ENTITY	GLP-1 ameliorates the proliferation activity of INS-1 cells inhibited by intermittent high glucose concentrations through the regulation of cyclins .
8764963	0	glucose	11,18	INS-1	125,130	glucose	INS-1	MESH:D005947	2305	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|potential potential|nmod|END_ENTITY	Effects of glucose , forskolin and tolbutamide on membrane potential and insulin secretion in the insulin-secreting cell line INS-1 .
9006960	0	glucose	13,20	INS-1	92,97	glucose	INS-1	MESH:D005947	2305	Chemical	Gene	START_ENTITY|nmod|genes genes|acl|coding coding|nmod|enzymes enzymes|nmod|line line|appos|END_ENTITY	Induction by glucose of genes coding for glycolytic enzymes in a pancreatic beta-cell line -LRB- INS-1 -RRB- .
9651378	1	glucose	192,199	INS-1	213,218	glucose	INS-1	MESH:D005947	2305	Chemical	Gene	substrate-mediated|nmod|START_ENTITY substrate-mediated|nmod|cells cells|compound|END_ENTITY	Synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS-1 cells .
9651378	5	glucose	843,850	INS-1	800,805	glucose	IGF-I	MESH:D005947	3479	Chemical	Gene	50-fold|nmod|START_ENTITY +|dep|50-fold +|nsubj|> >|compound|END_ENTITY	The combination of IGF-I and glucose was synergistic , increasing INS-1 cell proliferation > 50-fold at 15 mM glucose + 10 nM IGF-I .
12800089	3	glucose	623,630	IRS-1	639,644	glucose	IRS-1	MESH:D005947	3667	Chemical	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	L6 skeletal muscle cells -LRB- L6 cells -RRB- were treated with inhibitors of protein-tyrosine phosphatases , proteasomal degradation , and mammalian_target_of_rapamycin -LRB- mTOR -RRB- , and the effects of insulin on glucose uptake , IRS-1 tyrosine phosphorylation , phosphatidylinositol -LRB- PI -RRB- 3-kinase activity , and IRS-1 mass were examined .
16037106	0	glucose	123,130	IRS-2	101,106	glucose	IRS-2	MESH:D005947	8660	Chemical	Gene	homeostasis|compound|START_ENTITY homeostasis|appos|END_ENTITY	Polymorphisms in the insulin_receptor_substrate-1 -LRB- IRS-1 -RRB- gene and the insulin_receptor_substrate-2 -LRB- IRS-2 -RRB- gene influence glucose homeostasis and body mass index in women with polycystic_ovary_syndrome and non-hyperandrogenic controls .
16574657	0	glucose	43,50	IRS-2	23,28	glucose	IRS-2	MESH:D005947	29376(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Specific regulation of IRS-2 expression by glucose in rat primary pancreatic islet beta-cells .
19587264	0	glucose	38,45	IRS1	15,19	glucose	IRS1	MESH:D005947	16367(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY leads|nmod|uptake leads|nsubj|Degradation Degradation|nmod|END_ENTITY	Degradation of IRS1 leads to impaired glucose uptake in adipose tissue of the type_2_diabetes mouse model TALLYHO/Jng .
10198307	0	glucose	44,51	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	action|nmod|START_ENTITY action|compound|END_ENTITY	Insulin action on heart and skeletal muscle glucose uptake in weight lifters and endurance athletes .
10320055	0	glucose	41,48	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	relatives|amod|START_ENTITY action|nmod|relatives action|compound|END_ENTITY	Insulin action and secretion in healthy , glucose tolerant first degree relatives of patients with type_2_diabetes_mellitus .
10321442	0	glucose	21,28	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	response|compound|START_ENTITY modifies|dobj|response modifies|nsubj|END_ENTITY	Insulin modifies the glucose response to mental stress independently of forearm blood flow .
10325757	0	glucose	45,52	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	concentrations|compound|START_ENTITY comparison|nmod|concentrations hypoglycaemia|dep|comparison hypoglycaemia|amod|END_ENTITY	Insulin induced hypoglycaemia : comparison of glucose and glycerol concentrations in plasma and microdialysate from subcutaneous adipose tissue .
10342341	0	glucose	52,59	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY secretion|nmod|tolerance secretion|compound|END_ENTITY	Insulin secretion and action in different stages of glucose tolerance in Asian Indians .
10444433	0	glucose	22,29	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	transport|compound|START_ENTITY regulation|nmod|transport regulation|compound|END_ENTITY	Insulin regulation of glucose transport and phosphorylation in skeletal muscle assessed by PET .
10459561	0	glucose	21,28	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	effectiveness|compound|START_ENTITY sensitivity|appos|effectiveness sensitivity|compound|END_ENTITY	Insulin sensitivity , glucose effectiveness , and insulin secretion in nondiabetic offspring of patients with non-insulin-dependent_diabetes_mellitus : a cross-sectional study .
10551191	0	glucose	57,64	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY improves|dobj|control improves|nsubj|adjustment adjustment|compound|END_ENTITY	Insulin adjustment by a diabetes nurse educator improves glucose control in insulin-requiring diabetic patients : a randomized trial .
10798747	0	glucose	121,128	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	infusion|nmod|START_ENTITY estimated|nmod|infusion estimated|nsubj|secretion secretion|compound|END_ENTITY	Insulin secretion and sensitivity after simultaneous pancreas-kidney transplantation estimated by continuous infusion of glucose with model assessment .
10995598	0	glucose	23,30	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY sensitivity|nmod|metabolism sensitivity|compound|END_ENTITY	Insulin sensitivity of glucose and fat metabolism in severe sepsis .
10998755	0	glucose	84,91	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	technique|compound|START_ENTITY system|nmod|technique resistance|nmod|system resistance|compound|END_ENTITY	Insulin resistance and changes in the blood_coagulation-fibrinolysis system after a glucose clamp technique in patients with type_2_diabetes_mellitus .
11095426	0	glucose	20,27	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Insulin response to glucose is lower in individuals homozygous for the Arg 64 variant of the beta-3-adrenergic receptor .
11131100	0	glucose	70,77	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY management|nmod|control insulin|nmod|management aspart|dobj|insulin aspart|nsubj|END_ENTITY	Insulin aspart vs. human insulin in the management of long-term blood glucose control in Type_1_diabetes_mellitus : a randomized controlled trial .
1132602	1	glucose	101,108	Insulin	38,45	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY spectrum|nmod|tolerance responses|nmod|spectrum responses|compound|END_ENTITY	Insulin responses to oral carbohydrate over a wide spectrum of glucose tolerance .
11517008	0	glucose	81,88	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	tests|compound|START_ENTITY derived|nmod|tests values|acl|derived comparison|nmod|values sensitivity|dep|comparison sensitivity|compound|END_ENTITY	Insulin sensitivity in women : a comparison among values derived from intravenous glucose tolerance tests with different sampling frequency , oral glucose tolerance test or fasting .
11641528	0	glucose	46,53	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY secretion|nmod|tolerance secretion|compound|END_ENTITY	Insulin secretion and sensitivity during oral glucose tolerance test in Korean lean elderly women .
11692219	0	glucose	47,54	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY independence|nmod|tolerance independence|compound|END_ENTITY	Insulin independence and normalization of oral glucose tolerance test after islet cell allotransplantation .
11694699	0	glucose	35,42	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	lowers|dobj|START_ENTITY lowers|nsubj|lispro lispro|compound|END_ENTITY	Insulin lispro lowers postprandial glucose in prepubertal children with diabetes .
11815484	0	glucose	97,104	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	times|amod|START_ENTITY predicts|nmod|times release|parataxis|predicts release|nsubj|END_ENTITY	Insulin release in impaired_glucose_tolerance : oral minimal model predicts normal sensitivity to glucose but defective response times .
11825631	0	glucose	81,88	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY infusion|nmod|control application|nmod|infusion subcutaneous|dobj|application subcutaneous|nsubj|END_ENTITY	Insulin subcutaneous application vs. continuous infusion for postoperative blood glucose control in patients with non-insulin-dependent_diabetes_mellitus .
11932032	0	glucose	160,167	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY modified|dobj|test insulin|acl|modified derive|nmod|insulin diabetes|parataxis|derive diabetes|nsubj|sensitivity sensitivity|compound|END_ENTITY	Insulin sensitivity in type 2 diabetes : univariate and multivariate techniques to derive estimates of insulin sensitivity from the insulin modified intravenous glucose tolerance test -LRB- FSIGT -RRB- .
12032626	0	glucose	50,57	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	concentrations|compound|START_ENTITY rising|dobj|concentrations responses|acl|rising responses|amod|END_ENTITY	Insulin secretory responses to rising and falling glucose concentrations are delayed in subjects with impaired_glucose_tolerance .
12070172	0	glucose	32,39	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	production|compound|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Insulin inhibits hepatocellular glucose production by utilizing liver-enriched_transcriptional_inhibitory_protein to disrupt the association of CREB-binding_protein and RNA polymerase II with the phosphoenolpyruvate_carboxykinase gene promoter .
12376328	0	glucose	17,24	Insulin	0,7	glucose	Insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	production|compound|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Insulin inhibits glucose production by a direct effect in diabetic depancreatized dogs during euglycemia .
12421431	0	glucose	65,72	Insulin	127,134	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	related|nmod|START_ENTITY related|advmod|than than|advcl|fasting fasting|dobj|glucose glucose|dep|Study Study|compound|END_ENTITY	C-reactive_protein is more strongly related to post-glucose load glucose than to fasting glucose in non-diabetic subjects ; the Insulin Resistance Atherosclerosis Study .
12421431	0	glucose	89,96	Insulin	127,134	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	START_ENTITY|dep|Study Study|compound|END_ENTITY	C-reactive_protein is more strongly related to post-glucose load glucose than to fasting glucose in non-diabetic subjects ; the Insulin Resistance Atherosclerosis Study .
12436329	0	glucose	22,29	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	uptake|compound|START_ENTITY regulation|nmod|uptake regulation|compound|END_ENTITY	Insulin regulation of glucose uptake : a complex interplay of intracellular signalling pathways .
12448933	0	glucose	37,44	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY improves|dobj|control improves|nsubj|lispro lispro|compound|END_ENTITY	Insulin lispro improves postprandial glucose control in patients with diabetes_mellitus .
12477148	0	glucose	108,115	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY degrees|nmod|tolerance Ghanaians|nmod|degrees function|nmod|Ghanaians resistance|appos|function resistance|compound|END_ENTITY	Insulin resistance , beta cell function and cardiovascular risk factors in Ghanaians with varying degrees of glucose tolerance .
1259488	0	glucose	20,27	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Insulin response to glucose in hypermetabolic_burn patients .
12655415	0	glucose	118,125	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY assessment|nmod|test sensitivity|dep|assessment sensitivity|amod|END_ENTITY	Insulin sensitivity and beta-cell secretion in thalassaemia major with secondary haemochromatosis : assessment by oral glucose tolerance test .
12688632	0	glucose	69,76	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	concentration|compound|START_ENTITY process|nmod|concentration secretion|dep|process secretion|compound|END_ENTITY	Insulin secretion induced by palmitate -- a process fully dependent on glucose concentration .
12732668	0	glucose	25,32	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	uptake|compound|START_ENTITY stimulates|dobj|uptake stimulates|nsubj|END_ENTITY	Insulin stimulates liver glucose uptake in humans : an 18F-FDG PET Study .
1278602	0	glucose	47,54	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	tests|compound|START_ENTITY fatty_acid|nmod|tests fatty_acid|nsubj|END_ENTITY	Insulin and free fatty_acid levels during oral glucose tolerance tests and their relation to age in 70 healthy children .
1278607	0	glucose	25,32	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Insulin response to oral glucose in patients with a previous myocardial_infarction and in patients with peripheral_vascular_disease .
1310909	0	glucose	114,121	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY level|nmod|tolerance mechanism|nmod|level difference|nmod|mechanism ATPase|dep|difference resistance|dep|ATPase resistance|compound|END_ENTITY	Insulin resistance and Na + / K -LRB- + -RRB- - ATPase in hypertensive women : a difference in mechanism depending on the level of glucose tolerance .
1341607	0	glucose	19,26	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	kinetics|compound|START_ENTITY effects|nmod|kinetics effects|compound|END_ENTITY	Insulin effects on glucose kinetics in non-insulin-dependent diabetic patients with secondary failure to hypoglycaemic agents : role of different modes and rates of delivery .
1397697	0	glucose	60,67	Insulin	0,7	glucose	Insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	delivery|compound|START_ENTITY intraportal|dobj|delivery respond|xcomp|intraportal required|xcomp|respond required|nsubjpass|END_ENTITY	Insulin is required for the liver to respond to intraportal glucose delivery in the conscious dog .
14644433	0	glucose	19,26	Insulin	0,7	glucose	Insulin	MESH:D005947	42549(Tax:7227)	Chemical	Gene	metabolism|compound|START_ENTITY stimulates|dobj|metabolism stimulates|nsubj|END_ENTITY	Insulin stimulates glucose metabolism via the pentose_phosphate pathway in Drosophila Kc cells .
15131768	0	glucose	51,58	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	secretion|nmod|START_ENTITY secretion|amod|END_ENTITY	Insulin secretion and incretin hormones after oral glucose in non-obese subjects with impaired_glucose_tolerance .
15277384	0	glucose	59,66	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	uptake|compound|START_ENTITY stimulation|nmod|uptake curves|nmod|stimulation curves|amod|END_ENTITY	Insulin dose-response curves for stimulation of splanchnic glucose uptake and suppression of endogenous glucose production differ in nondiabetic humans and are abnormal in people with type 2 diabetes .
15297113	0	glucose	19,26	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	disposal|compound|START_ENTITY disposal|compound|END_ENTITY	Insulin stimulated glucose disposal in peripheral tissues studied with microdialysis and stable isotope tracers .
15351424	0	glucose	40,47	Insulin	0,7	glucose	Insulin	MESH:D005947	100060077(Tax:9796)	Chemical	Gene	transport|compound|START_ENTITY sensitivity|dobj|transport sensitivity|nsubj|END_ENTITY	Insulin sensitivity and skeletal muscle glucose transport in horses with equine polysaccharide storage myopathy .
1542855	0	glucose	18,25	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY action|nmod|metabolism action|compound|END_ENTITY	Insulin action on glucose and branched-chain amino_acid metabolism in cancer_cachexia : differential effects of insulin .
1547918	0	glucose	167,174	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	gene|compound|START_ENTITY expression|nmod|gene defect|nmod|expression associated|nmod|defect associated|nsubjpass|patients patients|compound|resistance resistance|compound|END_ENTITY	Insulin resistance in type 2 -LRB- non-insulin-dependent -RRB- diabetic patients and their relatives is not associated with a defect in the expression of the insulin-responsive glucose transporter -LRB- GLUT-4 -RRB- gene in human skeletal muscle .
15563978	0	glucose	58,65	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY development|nmod|tolerance capacity|nmod|development capacity|compound|END_ENTITY	Insulin secretion capacity in the development from normal glucose tolerance to type 2 diabetes .
15736120	0	glucose	31,38	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	indices|nmod|START_ENTITY indices|amod|END_ENTITY	Insulin sensitivity indices of glucose and free fatty_acid metabolism in obese children and adolescents in relation to serum lipids .
15853121	0	glucose	105,112	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	load|compound|START_ENTITY indices|nmod|load comparison|nmod|indices assessment|dep|comparison assessment|compound|END_ENTITY	Insulin sensitivity assessment in uncomplicated obese women : comparison of indices from fasting and oral glucose load with euglycemic_hyperinsulinemic_clamp .
15887790	0	glucose	21,28	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	decrease|compound|START_ENTITY responses|nmod|decrease responses|compound|END_ENTITY	Insulin responses to glucose and isoproterenol decrease with age .
15887827	0	glucose	29,36	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY role|nmod|control therapy|dep|role therapy|compound|END_ENTITY	Insulin therapy -- role beyond glucose control .
15937580	0	glucose	30,37	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY responses|nmod|tolerance responses|compound|END_ENTITY	Insulin responses to the oral glucose tolerance test in women of different ethnicity with polycystic_ovary_syndrome .
15959962	0	glucose	19,26	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY control|nmod|metabolism control|compound|END_ENTITY	Insulin control of glucose metabolism in man : a new kinetic analysis .
16014353	0	glucose	28,35	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	models|amod|START_ENTITY sensitivity|nmod|models sensitivity|compound|END_ENTITY	Insulin sensitivity by oral glucose minimal models : validation against clamp .
16194983	0	glucose	38,45	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	testing|compound|START_ENTITY derived|nmod|testing sensitivity|acl|derived sensitivity|compound|END_ENTITY	Insulin sensitivity derived from oral glucose tolerance testing in athletes : disagreement between available indices .
16272767	0	glucose	25,32	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	loading|compound|START_ENTITY END_ENTITY|nmod|loading	Insulin response to oral glucose loading and coronary_artery_disease in nondiabetics .
16337941	0	glucose	27,34	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	uptake|compound|START_ENTITY regulates|dobj|uptake regulates|nsubj|END_ENTITY	Insulin regulates neuronal glucose uptake by promoting translocation of glucose transporter GLUT3 .
16337941	0	glucose	72,79	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	GLUT3|compound|START_ENTITY translocation|nmod|GLUT3 promoting|dobj|translocation regulates|advcl|promoting regulates|nsubj|END_ENTITY	Insulin regulates neuronal glucose uptake by promoting translocation of glucose transporter GLUT3 .
16423619	0	glucose	54,61	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY quantified|nmod|test hypertension|acl|quantified resistance|nmod|hypertension resistance|compound|END_ENTITY	Insulin resistance in hypertension quantified by oral glucose tolerance test : comparison of methods .
16453026	0	glucose	70,77	Insulin	0,7	glucose	Insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	production|compound|START_ENTITY control|nmod|production dominate|dobj|control dominate|nsubj|effects effects|nmod:poss|END_ENTITY	Insulin 's direct effects on the liver dominate the control of hepatic glucose production .
16557150	0	glucose	148,155	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	lipopolysaccharide|nmod|START_ENTITY coadministration|nmod|lipopolysaccharide caused|nmod|coadministration injury|acl|caused reduces|dobj|injury reduces|nsubj|END_ENTITY	Insulin reduces the multiple organ injury and dysfunction caused by coadministration of lipopolysaccharide and peptidoglycan independently of blood glucose : role of glycogen_synthase_kinase-3beta inhibition .
16829342	0	glucose	72,79	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY subjects|nmod|tolerance differences|nmod|subjects sensitivity|dep|differences sensitivity|compound|END_ENTITY	Insulin sensitivity : gender-related differences in subjects with normal glucose tolerance .
16842476	0	glucose	85,92	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	levels|compound|START_ENTITY lowers|dobj|levels lowers|nsubj|detemir detemir|compound|END_ENTITY	Insulin detemir lowers the risk of hypoglycaemia and provides more consistent plasma glucose levels compared with NPH insulin in Type 1 diabetes .
16918591	0	glucose	32,39	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY sensitivity|nmod|test sensitivity|nsubj|END_ENTITY	Insulin sensitivity during oral glucose tolerance test and its relations to parameters of glucose metabolism and endothelial function in type 2 diabetic subjects under metformin and thiazolidinedione .
16918591	0	glucose	90,97	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY parameters|nmod|metabolism sensitivity|nmod|parameters sensitivity|nsubj|END_ENTITY	Insulin sensitivity during oral glucose tolerance test and its relations to parameters of glucose metabolism and endothelial function in type 2 diabetic subjects under metformin and thiazolidinedione .
16924660	0	glucose	17,24	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	inhibition|compound|START_ENTITY restores|dobj|inhibition restores|nsubj|END_ENTITY	Insulin restores glucose inhibition of adenosine transport by increasing the expression and activity of the equilibrative nucleoside transporter 2 in human umbilical vein endothelium .
17053859	0	glucose	108,115	Insulin	141,148	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	Injection|compound|START_ENTITY Injection|nmod|END_ENTITY	Optimization of whole-body positron emission tomography imaging by using delayed 2-deoxy-2 - -LSB- F-18 -RSB- fluoro-D : _ - glucose Injection following I.V. Insulin in diabetic patients .
17327334	0	glucose	65,72	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	fasting|dobj|START_ENTITY secretion|acl|fasting secretion|amod|END_ENTITY	Insulin secretion and insulin sensitivity in relation to fasting glucose in healthy subjects .
17582913	0	glucose	43,50	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY obtained|nmod|test obtained|nsubj|sensitivity sensitivity|compound|END_ENTITY	Insulin sensitivity obtained from the oral glucose tolerance test and its relationship with birthweight .
17635575	0	glucose	26,33	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	transport|compound|START_ENTITY regulate|dobj|transport regulate|nsubj|END_ENTITY	Insulin does not regulate glucose transport and metabolism in human endothelium .
17693932	0	glucose	83,90	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	control|nmod|START_ENTITY associated|nsubjpass|control A.|acl:relcl|associated regulates|nmod|A. regulates|nsubj|END_ENTITY	Insulin regulates macrophage activation through activin A. Strict control of serum glucose with insulin has been associated with a reduction in the development of multiple_organ_dysfunction syndrome potentially through alterations in macrophage activation .
17945585	0	glucose	59,66	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY rate|nmod|tolerance rate|amod|END_ENTITY	Insulin secretion rate and beta-cell sensitivity from oral glucose tolerance test in normotensive and normoglycemic humans .
18045815	0	glucose	18,25	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY action|nmod|metabolism action|compound|END_ENTITY	Insulin action on glucose and protein metabolism during L-carnitine supplementation in maintenance haemodialysis patients .
18270458	0	glucose	105,112	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY subjects|nmod|tolerance associated|nmod|subjects associated|nsubjpass|response response|compound|END_ENTITY	Insulin response to oral glucose load is associated with coronary_artery_disease in subjects with normal glucose tolerance .
18270458	0	glucose	25,32	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	load|compound|START_ENTITY response|nmod|load response|compound|END_ENTITY	Insulin response to oral glucose load is associated with coronary_artery_disease in subjects with normal glucose tolerance .
1874481	0	glucose	17,24	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	inhibition|compound|START_ENTITY prevents|dobj|inhibition prevents|nsubj|END_ENTITY	Insulin prevents glucose induced inhibition of angiotensin_II-stimulated aldosterone secretion .
1874934	0	glucose	19,26	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY effects|nmod|metabolism effects|compound|END_ENTITY	Insulin effects on glucose and potassium metabolism in vivo : evidence for selective insulin resistance in humans .
18772618	2	glucose	264,271	Insulin	229,236	glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY indispensable|nmod|control indispensable|nsubj|END_ENTITY	Insulin is indispensable for serum glucose control and diabetes patients are on the relative or absolute_deficient state of insulin .
1900667	0	glucose	47,54	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	infused|nmod|START_ENTITY rats|acl|infused resistance|nmod|rats resistance|compound|END_ENTITY	Insulin resistance in normal rats infused with glucose for 72 h. Insulin resistance is accentuated during periods of poor metabolic control in human non-insulin-dependent diabetes_mellitus .
19031221	0	glucose	25,32	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Insulin response to oral glucose in healthy , lean young women and patients with polycystic_ovary_syndrome .
19059535	0	glucose	116,123	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY assessment|nmod|test action|dep|assessment action|compound|END_ENTITY	Insulin action and secretion in hypertension in the absence of metabolic_syndrome : model-based assessment from oral glucose tolerance test .
19223652	0	glucose	123,130	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	nucleus|nmod|START_ENTITY neurons|nmod|nucleus response|nmod|neurons blunts|dobj|response blunts|nsubj|END_ENTITY	Insulin blunts the response of glucose-excited neurons in the ventrolateral-ventromedial hypothalamic nucleus to decreased glucose .
19430760	0	glucose	61,68	Insulin	96,103	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	response|nmod|START_ENTITY scan|nmod|response scan|dep|Study Study|compound|END_ENTITY	A genome-wide association scan for acute insulin response to glucose in Hispanic-Americans : the Insulin Resistance_Atherosclerosis Family Study -LRB- IRAS FS -RRB- .
19617231	0	glucose	33,40	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY associated|nmod|control associated|nsubjpass|resistance resistance|compound|END_ENTITY	Insulin resistance despite tight glucose control is associated with mortality in critically ill surgical patients .
1965168	0	glucose	18,25	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	transport|compound|START_ENTITY action|nmod|transport action|compound|END_ENTITY	Insulin action on glucose transport in isolated cardiac myocytes : signalling pathways and diabetes-induced alterations .
1991798	0	glucose	65,72	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY restricted|nmod|metabolism defect|acl|restricted resistance|dep|defect resistance|compound|END_ENTITY	Insulin resistance of puberty : a defect restricted to peripheral glucose metabolism .
2041930	0	glucose	31,38	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY resistance|nmod|test resistance|compound|END_ENTITY	Insulin resistance in the oral glucose tolerance test -- a link with hypertension .
2061244	0	glucose	26,33	Insulin	0,7	glucose	Insulin	MESH:D005947	280829(Tax:9913)	Chemical	Gene	responsiveness|compound|START_ENTITY responsiveness|nmod|responsiveness responsiveness|nsubj|END_ENTITY	Insulin responsiveness to glucose and tissue responsiveness to insulin in lactating , pregnant , and nonpregnant , nonlactating beef cows .
20634790	0	glucose	40,47	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	influences|dobj|START_ENTITY influences|nsubj|END_ENTITY	Insulin differentially influences brain glucose and lactate in traumatic brain injured patients .
20806184	0	glucose	42,49	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	utilization|compound|START_ENTITY regulator|nmod|utilization END_ENTITY|nmod|regulator	Insulin as the main regulator of cellular glucose utilization -- aetiological aspects of insulin resistance .
20837822	0	glucose	70,77	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY resistance|nmod|metabolism resistance|compound|END_ENTITY	Insulin resistance and Alzheimer-like_reductions in regional cerebral glucose metabolism for cognitively normal adults with prediabetes or early type_2_diabetes .
20870309	0	glucose	64,71	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	excursions|compound|START_ENTITY prediction|nmod|excursions based|nmod|prediction based|nsubj|optimization optimization|compound|END_ENTITY	Insulin dosage optimization based on prediction of postprandial glucose excursions under uncertain parameters and food intake .
21042331	0	glucose	114,121	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	regulation|compound|START_ENTITY involved|nmod|regulation involved|dobj|resistance resistance|compound|END_ENTITY	Insulin resistance in tetraplegia but not in mid-thoracic paraplegia : is the mid-thoracic spinal cord involved in glucose regulation ?
21314720	0	glucose	51,58	Insulin	0,7	glucose	Insulin	MESH:D005947	100060077(Tax:9796)	Chemical	Gene	transporters|compound|START_ENTITY alters|dobj|transporters alters|nsubj|resistance resistance|compound|END_ENTITY	Insulin resistance selectively alters cell-surface glucose transporters but not their total protein expression in equine skeletal muscle .
21321933	0	glucose	33,40	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	transport|compound|START_ENTITY regulates|dobj|transport regulates|nsubj|END_ENTITY	Insulin regulates GLUT1-mediated glucose transport in MG-63 human osteosarcoma cells .
21559284	0	glucose	109,116	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	load|compound|START_ENTITY impact|nmod|load END_ENTITY|dep|impact	Insulin and GH signaling in human skeletal muscle in vivo following exogenous GH exposure : impact of an oral glucose load .
2179752	1	glucose	92,99	Insulin	44,51	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	insulin|compound|START_ENTITY absorption|nmod|insulin absorption|amod|END_ENTITY	Insulin absorption and plasma concentrations of glucose and free insulin .
2180396	0	glucose	110,117	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY degrees|nmod|tolerance subjects|nmod|degrees associated|nmod|subjects associated|nsubjpass|resistance resistance|compound|END_ENTITY	Insulin resistance is associated with lipid and lipoprotein_abnormalities in subjects with varying degrees of glucose tolerance .
2183610	0	glucose	49,56	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	responsiveness|xcomp|START_ENTITY responsiveness|nsubj|sensitivity sensitivity|compound|END_ENTITY	Insulin sensitivity and B-cell responsiveness to glucose during late pregnancy in lean_and_moderately_obese women with normal_glucose_tolerance or mild gestational_diabetes .
2185935	0	glucose	52,59	Insulin	0,7	glucose	Insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	control|compound|START_ENTITY effects|nmod|control therapy|dep|effects therapy|compound|END_ENTITY	Insulin therapy on the peritoneal route : effects on glucose control in experimental insulin dependent diabetes .
2189770	0	glucose	22,29	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY regulation|nmod|metabolism regulation|compound|END_ENTITY	Insulin regulation of glucose and lipid metabolism in massive obesity .
21974813	0	glucose	103,110	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY function|nmod|tolerance function|nsubj|secretion secretion|compound|END_ENTITY	Insulin secretion , nutritional status and respiratory function in cystic fibrosis patients with normal glucose tolerance .
22309514	0	glucose	115,122	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	regulation|compound|START_ENTITY women|nmod|regulation feature|nmod|women resistance|dep|feature resistance|compound|END_ENTITY	Insulin resistance but not impaired b-cell function : a key feature in Chinese normal-weight PCOS women with normal glucose regulation .
22426845	0	glucose	136,143	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	study|compound|START_ENTITY double|dobj|study END_ENTITY|dep|double	Insulin secretion and sensitivity after single-dose amisulpride , olanzapine or placebo in young male subjects : double blind , cross-over glucose clamp study .
22435928	0	glucose	41,48	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	period|compound|START_ENTITY based|nmod|period secretion|acl|based secretion|compound|END_ENTITY	Insulin secretion based on the late oral glucose tolerance test period and incident diabetes : the San Antonio Heart Study .
2262424	0	glucose	26,33	Insulin	0,7	glucose	Insulin	MESH:D005947	105613195	Chemical	Gene	responsiveness|compound|START_ENTITY responsiveness|nmod|responsiveness responsiveness|nsubj|END_ENTITY	Insulin responsiveness to glucose and tissue responsiveness to insulin over the feeding cycle in sheep .
22688918	0	glucose	25,32	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	stimulation|compound|START_ENTITY secreted|nmod|stimulation secreted|nsubjpass|END_ENTITY	Insulin is secreted upon glucose stimulation by both gastrointestinal enteroendocrine K-cells and L-cells engineered with the preproinsulin gene .
22775404	0	glucose	167,174	Insulin	268,275	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	monitoring|compound|START_ENTITY using|dobj|monitoring daily|dep|using receiving|advmod|daily diabetes|acl|receiving diabetes|dep|COmparison COmparison|nmod|Cgm Cgm|nmod|OptimizatioN OptimizatioN|compound|END_ENTITY	A crossover comparison of glycemic variations in Japanese patients with type 1 diabetes receiving insulin glargine versus insulin detemir twice daily using continuous glucose monitoring -LRB- CGM -RRB- : J COLLECTION -LRB- Jikei COmparison of Lantus and LEvemir with Cgm for Thinking Insulin OptimizatioN -RRB- .
23127112	0	glucose	86,93	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY have|dobj|tolerance PCOS|acl:relcl|have women|nmod|PCOS resistance|nmod|women resistance|amod|END_ENTITY	Insulin resistance and cardiovascular risk factors in women with PCOS who have normal glucose tolerance test .
23403945	0	glucose	34,41	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	infusion|compound|START_ENTITY induces|nsubj|infusion suppresses|advcl|induces suppresses|nsubj|infusion infusion|compound|END_ENTITY	Insulin infusion suppresses while glucose infusion induces Toll-like receptors and high-mobility_group-B1 protein expression in mononuclear cells of type 1 diabetes patients .
23489701	0	glucose	71,78	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY resistance|nmod|tolerance resistance|compound|END_ENTITY	Insulin resistance in first-trimester pregnant women with pre-pregnant glucose tolerance and history of recurrent spontaneous_abortion .
23721205	0	glucose	76,83	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	levels|compound|START_ENTITY reduces|dobj|levels reduces|nsubj|END_ENTITY	Insulin secreted from genetically engineered intestinal cells reduces blood glucose levels in diabetic mice .
23762265	0	glucose	17,24	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	consumption|compound|START_ENTITY promotes|dobj|consumption promotes|nsubj|END_ENTITY	Insulin promotes glucose consumption via regulation of miR-99a / mTOR/PKM2 pathway .
24363940	0	glucose	58,65	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	administration|compound|START_ENTITY assessed|nmod|administration sensitivity|acl|assessed sensitivity|compound|END_ENTITY	Insulin sensitivity assessed by stable isotopes with oral glucose administration : validation with euglycaemic clamp .
24705280	0	glucose	74,81	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY dynamics|nmod|tolerance dynamics|compound|END_ENTITY	Insulin dynamics in young women with polycystic_ovary_syndrome and normal glucose tolerance across categories of body mass index .
24731625	0	glucose	19,26	Insulin	0,7	glucose	Insulin	MESH:D005947	280829(Tax:9913)	Chemical	Gene	uptake|compound|START_ENTITY stimulates|dobj|uptake stimulates|nsubj|END_ENTITY	Insulin stimulates glucose uptake via a phosphatidylinositide 3-kinase-linked signaling pathway in bovine mammary epithelial cells .
24895527	0	glucose	18,25	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	consumption|compound|START_ENTITY regulates|dobj|consumption regulates|nsubj|END_ENTITY	Insulin regulates glucose consumption and lactate production through reactive_oxygen_species and pyruvate_kinase_M2 .
2578418	1	glucose	118,125	Insulin	76,83	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	dynamics|nmod|START_ENTITY dynamics|nsubj|END_ENTITY	Insulin secretory dynamics in response to glucose , 3-isobutyl-1-methylxanthine , and potassium .
25899581	0	glucose	64,71	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	studies|compound|START_ENTITY assessed|nmod|studies diabetes|acl|assessed patients|nmod|diabetes resistance|nmod|patients resistance|compound|END_ENTITY	Insulin resistance in patients with type 1 diabetes assessed by glucose clamp studies : systematic review and meta-analysis .
26023321	0	glucose	42,49	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	absorption|compound|START_ENTITY stimulates|dobj|absorption stimulates|nsubj|END_ENTITY	Insulin stimulates SGLT2-mediated tubular glucose absorption via oxidative stress generation .
26131263	0	glucose	68,75	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	regulation|compound|START_ENTITY women|nmod|regulation secretion|nmod|women secretion|compound|END_ENTITY	Insulin secretion and tolerance of women with different gestational glucose regulation one year postpartum .
26232910	0	glucose	86,93	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	rates|nmod|START_ENTITY results|nmod|rates results|amod|END_ENTITY	Insulin degludec results in lower rates of nocturnal_hypoglycaemia and fasting plasma glucose vs. insulin glargine : A meta-analysis of seven clinical trials .
26260658	0	glucose	80,87	Insulin	19,26	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	uptake|compound|START_ENTITY AD|nmod|uptake risk|nmod|AD linked|nmod|risk linked|nsubjpass|resistance resistance|compound|END_ENTITY	Alzheimer_disease : Insulin resistance could be linked to risk of AD via reduced glucose uptake .
26260658	0	glucose	80,87	Insulin	19,26	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	uptake|compound|START_ENTITY AD|nmod|uptake risk|nmod|AD linked|nmod|risk linked|nsubjpass|resistance resistance|compound|END_ENTITY	Alzheimer_disease : Insulin resistance could be linked to risk of AD via reduced glucose uptake .
26288254	0	glucose	68,75	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	levels|compound|START_ENTITY influence|dobj|levels influence|nsubj|resistance resistance|compound|END_ENTITY	Insulin resistance and b-cell function influence postprandial blood glucose levels in Japanese patients with gestational_diabetes_mellitus .
26556780	0	glucose	22,29	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY improve|dobj|control improve|nsubj|pumps pumps|compound|END_ENTITY	Insulin pumps improve glucose control in children with type 1 diabetes , study finds .
2660587	0	glucose	32,39	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	production|compound|START_ENTITY inhibition|nmod|production inhibition|compound|END_ENTITY	Insulin inhibition of overnight glucose production and gluconeogenesis from lactate in NIDDM .
2671856	1	glucose	66,73	Insulin	34,41	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	concentration|compound|START_ENTITY based|nmod|concentration therapy|acl|based therapy|compound|END_ENTITY	Insulin therapy , based on urine glucose concentration , controlled by a dosage-measuring computer -RSB- .
2682447	0	glucose	69,76	Insulin	1,8	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	-RSB-|compound|START_ENTITY tested|nmod|-RSB- tested|nsubj|metabolism metabolism|compound|END_ENTITY	-LSB- Insulin metabolism in obese children tested by oral and intravenous glucose loading -RSB- .
2908423	0	glucose	16,23	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	uptake|compound|START_ENTITY affects|dobj|uptake affects|nsubj|END_ENTITY	Insulin affects glucose uptake by muscle and mammary tissues of lactating ewes .
2999163	0	glucose	23,30	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	transport|compound|START_ENTITY stimulation|nmod|transport stimulation|compound|END_ENTITY	Insulin stimulation of glucose transport and metabolism in a human Wilms ' _ tumor-derived myoblast-like cell line : modulation of hormone effects by glucose_deprivation .
3042031	0	glucose	76,83	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	oxidation|compound|START_ENTITY enhance|dobj|oxidation enhance|nsubj|END_ENTITY	Insulin , somatomedin-C , human chorionic gonadotropin , and forskolin enhance glucose oxidation by granulosa cells .
3042578	0	glucose	56,63	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	ingestion|compound|START_ENTITY modulates|nmod|ingestion modulates|nsubj|END_ENTITY	Insulin modulates early-phase noradrenaline response to glucose ingestion in humans .
3052595	0	glucose	128,135	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	transport|compound|START_ENTITY augmentation|nmod|transport glycolysis|nmod|augmentation activation|nmod|glycolysis regulation|dep|activation regulation|compound|END_ENTITY	Insulin regulation of glucose metabolism in HT29 colonic_adenocarcinoma cells : activation of glycolysis without augmentation of glucose transport .
3052595	0	glucose	22,29	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY regulation|nmod|metabolism regulation|compound|END_ENTITY	Insulin regulation of glucose metabolism in HT29 colonic_adenocarcinoma cells : activation of glycolysis without augmentation of glucose transport .
3056137	0	glucose	40,47	Insulin	0,7	glucose	Insulin	MESH:D005947	280829(Tax:9913)	Chemical	Gene	infusion|compound|START_ENTITY responses|nmod|infusion responses|compound|END_ENTITY	Insulin and growth hormone responses to glucose infusion in mature and first-lactation dairy cows .
3296383	4	glucose	630,637	Insulin	596,603	glucose	insulin	MESH:D005947	3630	Chemical	Gene	oxidation|compound|START_ENTITY adipose|dobj|oxidation adipose|nsubj|stimulated stimulated|compound|END_ENTITY	Insulin stimulated adipose tissue glucose oxidation in a dose-dependent way in the control subjects .
3300653	0	glucose	42,49	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	transport|compound|START_ENTITY membrane|dobj|transport membrane|nsubj|stimulation stimulation|compound|END_ENTITY	Insulin stimulation of adipocyte membrane glucose transport .
3301158	0	glucose	21,28	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	infusion|compound|START_ENTITY secretion|nmod|infusion secretion|nsubj|END_ENTITY	Insulin secretion to glucose infusion in gestational diabetes subjects with differing DNA polymorphisms flanking the insulin gene .
3306155	0	glucose	39,46	Insulin	0,7	glucose	Insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	administration|compound|START_ENTITY response|nmod|administration response|compound|END_ENTITY	Insulin response following intravenous glucose administration in dogs with obstructive_jaundice .
3514335	0	glucose	56,63	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	Insulin and C-peptide levels after oral and intravenous glucose .
3515701	0	glucose	37,44	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	tests|compound|START_ENTITY secretion|nmod|tests secretion|nsubj|END_ENTITY	Insulin secretion during intravenous glucose tolerance tests in non-insulin-dependent_diabetes_in_the_young .
3522623	0	glucose	42,49	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	parameters|compound|START_ENTITY affect|dobj|parameters affect|nsubj|END_ENTITY	Insulin oscillations per se do not affect glucose turnover parameters in normal man .
3527748	0	glucose	23,30	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	uptake|compound|START_ENTITY stimulation|nmod|uptake stimulation|compound|END_ENTITY	Insulin stimulation of glucose uptake and the transmembrane potential of muscle cells in culture .
3528428	0	glucose	33,40	Insulin	0,7	glucose	Insulin	MESH:D005947	105613195	Chemical	Gene	injection|compound|START_ENTITY responses|nmod|injection responses|compound|END_ENTITY	Insulin and glucose responses to glucose injection in fed and fasted obese and lean sheep .
3529983	0	glucose	72,79	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY degrees|nmod|tolerance sensitivity|nmod|degrees sensitivity|nsubj|END_ENTITY	Insulin sensitivity in adipocytes from subjects with varying degrees of glucose tolerance .
3530110	0	glucose	111,118	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	loading|compound|START_ENTITY responsible|nmod|loading factor|amod|responsible factor|nsubj|metabolism metabolism|compound|END_ENTITY	Insulin metabolism is a major factor responsible for high or low peripheral insulin levels in response to oral glucose loading in the healthy man .
3533681	0	glucose	92,99	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	characteristics|nmod|START_ENTITY characteristics|amod|END_ENTITY	Insulin dose-response characteristics for suppression of glycerol release and conversion to glucose in humans .
3546049	0	glucose	110,117	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	transporters|compound|START_ENTITY translocation|nmod|transporters stimulates|nmod|translocation stimulates|nsubj|END_ENTITY	Insulin stimulates glucose transport in isolated human adipose cells through a translocation of intracellular glucose transporters to the plasma membrane : a preliminary report .
3546049	0	glucose	19,26	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	transport|compound|START_ENTITY stimulates|dobj|transport stimulates|nsubj|END_ENTITY	Insulin stimulates glucose transport in isolated human adipose cells through a translocation of intracellular glucose transporters to the plasma membrane : a preliminary report .
361768	0	glucose	50,57	Insulin	0,7	glucose	Insulin	MESH:D005947	280829(Tax:9913)	Chemical	Gene	responses|nmod|START_ENTITY secretion|dep|responses secretion|compound|END_ENTITY	Insulin secretion in lactating cows : responses to glucose infused intravenously in normal , ketonemic , and starved animals .
371340	0	glucose	61,68	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	stimulation|amod|START_ENTITY END_ENTITY|nmod|stimulation	Insulin in portal , hepatic and peripheral venous blood after glucose , tolbutamide and glipizide stimulation .
3888200	0	glucose	79,86	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	stimulated|nmod|START_ENTITY subjects|acl|stimulated secretion|nmod|subjects secretion|nsubj|END_ENTITY	Insulin and C-peptide secretion from B cells in human subjects stimulated with glucose .
3888495	0	glucose	34,41	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	homeostasis|compound|START_ENTITY effect|nmod|homeostasis treatment|dep|effect treatment|compound|END_ENTITY	Insulin pump treatment : effect on glucose homeostasis , metabolites , hormones , insulin antibodies and quality of life .
3898086	0	glucose	42,49	Insulin	0,7	glucose	Insulin	MESH:D005947	100009181(Tax:9986)	Chemical	Gene	uptake|compound|START_ENTITY binding|nmod|uptake binding|amod|END_ENTITY	Insulin binding and effects of insulin on glucose uptake and metabolism in cultured rabbit coronary microvessel endothelium .
3901231	1	glucose	65,72	Insulin	31,38	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY saliva|nmod|tolerance END_ENTITY|nmod|saliva	I. Insulin in saliva during the oral glucose tolerance test in female patients .
3905736	0	glucose	20,27	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Insulin response to glucose in estrous and diestrous_obese and lean heifers .
3911737	0	glucose	89,96	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	normalizes|nmod|START_ENTITY normalizes|nsubj|infusion infusion|compound|END_ENTITY	Insulin infusion normalizes cardiovascular responses and plasma noradrenaline after oral glucose in type 1 -LRB- insulin-dependent -RRB- diabetes .
399844	0	glucose	79,86	Insulin	1,8	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY response|nmod|test volunteers|nmod|response response|nmod|volunteers response|compound|END_ENTITY	-LSB- Insulin response and NEFA behavior in volunteers with a flat response to oral glucose tolerance test -RSB- .
4143593	0	glucose	20,27	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Insulin response to glucose in patients with peripheral_vascular_disease , arteritis , and Raynaud 's _ phenomenon .
4553012	0	glucose	58,65	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|END_ENTITY	Insulin release from human foetal pancreas in response to glucose , leucine and arginine .
4566096	1	glucose	79,86	Insulin	62,69	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	transport|compound|START_ENTITY release|appos|transport release|compound|END_ENTITY	Insulin release , glucose transport , glucose oxidation , membrane permeability and ultrastructure .
4566096	1	glucose	98,105	Insulin	62,69	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	oxidation|compound|START_ENTITY transport|appos|oxidation release|appos|transport release|compound|END_ENTITY	Insulin release , glucose transport , glucose oxidation , membrane permeability and ultrastructure .
4795360	0	glucose	23,30	Insulin	0,7	glucose	Insulin	MESH:D005947	396145(Tax:9031)	Chemical	Gene	entry|compound|START_ENTITY stimulation|nmod|entry stimulation|compound|END_ENTITY	Insulin stimulation of glucose entry in chick fibroblasts and HeLa cells .
504775	0	glucose	19,26	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	utilization|compound|START_ENTITY effects|nmod|utilization effects|nsubj|END_ENTITY	Insulin effects on glucose utilization by human lymphocytes .
514079	0	glucose	79,86	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	stimulations|nmod|START_ENTITY END_ENTITY|nmod|stimulations	Insulin secretory dynamics after two consecutive intravenous stimulations with glucose and/or tolbutamide .
5355342	0	glucose	21,28	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	responses|nmod|START_ENTITY responses|compound|END_ENTITY	Insulin responses to glucose : evidence for a two pool system in man .
5800368	0	glucose	70,77	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY response|nmod|tolerance response|compound|END_ENTITY	Insulin and corticoid response to intravenous fructose in relation to glucose tolerance .
6089865	0	glucose	20,27	Insulin	0,7	glucose	Insulin	MESH:D005947	105613195	Chemical	Gene	tolerance|compound|START_ENTITY response|nmod|tolerance response|compound|END_ENTITY	Insulin response to glucose and glucose tolerance following feeding in sheep .
6141989	0	glucose	103,110	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	infusion|compound|START_ENTITY assessed|nmod|infusion assessed|nsubj|sensitivity sensitivity|compound|END_ENTITY	Insulin sensitivity in pancreatitis , liver_diseases , steroid treatment and hyperthyroidism assessed by glucose , insulin and somatostatin infusion .
6331036	0	glucose	39,46	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	guided|nmod|START_ENTITY test|acl|guided test|compound|END_ENTITY	Insulin hypoglycaemia test guided by a glucose controlled insulin infusion system .
6346965	0	glucose	52,59	Insulin	0,7	glucose	Insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	loading|compound|START_ENTITY kinetics|nmod|loading kinetics|nsubj|END_ENTITY	Insulin kinetics in juvenile canine diabetics after glucose loading .
6347772	0	glucose	75,82	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY patients|nmod|tolerance cells|nmod|patients binding|nmod|cells binding|nsubj|END_ENTITY	Insulin binding and responsiveness in fat cells from patients with reduced glucose tolerance and type_II_diabetes .
6349736	0	glucose	29,36	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY secretion|nmod|test secretion|nsubj|END_ENTITY	Insulin secretion during the glucose tolerance test in antisocial personality .
6351380	0	glucose	25,32	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Insulin response to oral glucose in young African and Indian noninsulin-dependent diabetic patients in Natal .
6365504	0	glucose	61,68	Insulin	1,8	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	-RSB-|compound|START_ENTITY chronic_liver_diseases|nmod|-RSB- chronic_liver_diseases|nsubj|END_ENTITY	-LSB- Insulin and C-peptide in chronic_liver_diseases during oral glucose tolerance testing -RSB- .
6387366	0	glucose	102,109	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	transport|compound|START_ENTITY evaluation|nmod|transport resistance|dep|evaluation resistance|compound|END_ENTITY	Insulin resistance in the aged : a quantitative evaluation of in vivo insulin sensitivity and in vitro glucose transport .
6387959	0	glucose	25,32	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Insulin response to oral glucose in young , non-obese Indian males with myocardial_infarction .
643383	0	glucose	24,31	Insulin	0,7	glucose	Insulin	MESH:D005947	105613195	Chemical	Gene	utilization|compound|START_ENTITY effect|nmod|utilization effect|compound|END_ENTITY	Insulin effect on fetal glucose utilization .
6435558	0	glucose	36,43	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY improves|dobj|control improves|nsubj|therapy therapy|compound|END_ENTITY	Insulin pump therapy improves blood glucose control during hyperalimentation .
6455440	0	glucose	72,79	Insulin	0,7	glucose	Insulin	MESH:D005947	280829(Tax:9913)	Chemical	Gene	transport|compound|START_ENTITY stimulate|nmod|transport stimulate|nsubj|factors factors|compound|END_ENTITY	Insulin and growth factors stimulate rapid posttranslational changes in glucose transport in ovarian granulosa cells .
6749586	0	glucose	101,108	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	ingestion|compound|START_ENTITY hepatic_insulin_retention_and_splanchnic_carbohydrate_metabolism|nmod|ingestion rate|appos|hepatic_insulin_retention_and_splanchnic_carbohydrate_metabolism rate|compound|END_ENTITY	Insulin production rate , hepatic_insulin_retention_and_splanchnic_carbohydrate_metabolism after oral glucose ingestion in hyperinsulinaemic_Type_2 -LRB- non-insulin-dependent -RRB- diabetes mellitus .
6752636	0	glucose	35,42	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	load|compound|START_ENTITY response|nmod|load response|compound|END_ENTITY	Insulin secretory response to oral glucose load , diabetic_microangiopathy and diabetic control : a study in non-insulin dependent diabetics .
6756836	0	glucose	41,48	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	sensor|compound|START_ENTITY need|dobj|sensor systems|dep|need systems|amod|END_ENTITY	Insulin delivery systems : do they need a glucose sensor ?
6757268	0	glucose	43,50	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	uptake|compound|START_ENTITY velocity|nmod|uptake increases|dobj|velocity increases|nsubj|END_ENTITY	Insulin increases the maximum velocity for glucose uptake without altering the Michaelis constant in man .
6759079	0	glucose	21,28	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	responses|acl|START_ENTITY responses|compound|END_ENTITY	Insulin responses to glucose in non-insulin-dependent diabetic subjects with and without the chlorpropamide-alcohol flush : effect of salicylate and naloxone .
6765540	0	glucose	159,166	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	technique|compound|START_ENTITY concentrations|nmod|technique concentrations|compound|END_ENTITY	Insulin concentrations and time-action profiles of three different intermediate-acting insulin preparations in nondiabetic volunteers under glucose-controlled glucose infusion technique .
6990173	0	glucose	63,70	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	control|nmod|START_ENTITY improves|advcl|control improves|nsubj|secretion secretion|compound|END_ENTITY	Insulin secretion improves following dietary control of plasma glucose in severely hyperglycemic obese patients .
6991320	0	glucose	61,68	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	kinetics|compound|START_ENTITY response|nmod|kinetics analyzed|nmod|response analyzed|nsubj|resistance resistance|compound|END_ENTITY	Insulin resistance in obesity as analyzed by the response of glucose kinetics to glucagon infusion .
6996761	0	glucose	99,106	Insulin	1,8	glucose	Insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	-RSB-|compound|START_ENTITY administration|nmod|-RSB- secretion|nmod|administration secretion|nsubj|END_ENTITY	-LSB- Insulin secretion in dogs with experimental pancreatitis to the intrapancreatic administration of glucose -RSB- .
7004047	0	glucose	35,42	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	load|compound|START_ENTITY response|nmod|load response|compound|END_ENTITY	Insulin response to an intravenous glucose load in potentially diabetic pregnant women .
7037532	0	glucose	121,128	Insulin	0,7	glucose	Insulin	MESH:D005947	396145(Tax:9031)	Chemical	Gene	changes|nmod|START_ENTITY responses|nmod|changes END_ENTITY|dep|responses	Insulin , pancreatic_polypeptide , and glucagon release from the chicken pancreas in vitro : responses to changes in medium glucose and free fatty_acid content .
7042427	0	glucose	102,109	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	absorption|dep|START_ENTITY absorption|compound|END_ENTITY	Insulin absorption from the abdomen and the thigh in healthy subjects during rest and exercise : blood glucose , plasma insulin , growth_hormone , adrenaline and noradrenaline levels .
7485299	0	glucose	29,36	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	messenger|compound|START_ENTITY ribonucleic_acid|nsubj|messenger modulate|ccomp|ribonucleic_acid modulate|nsubj|END_ENTITY	Insulin and glucose modulate glucose transporter messenger ribonucleic_acid expression and glucose uptake in trophoblasts isolated from first-trimester chorionic villi .
7575481	0	glucose	65,72	Insulin	0,7	glucose	Insulin	MESH:D005947	378695(Tax:8355)	Chemical	Gene	translocation|compound|START_ENTITY stimulate|dobj|translocation factor|ccomp|stimulate factor|nsubj|END_ENTITY	Insulin and insulin-like growth factor I -LRB- IGF-I -RRB- stimulate GLUT4 glucose transporter translocation in Xenopus oocytes .
7635936	0	glucose	44,51	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	action|nmod|START_ENTITY action|compound|END_ENTITY	Insulin action on heart and skeletal muscle glucose uptake in essential hypertension .
7672499	0	glucose	22,29	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	turnover|compound|START_ENTITY regulation|nmod|turnover regulation|compound|END_ENTITY	Insulin regulation of glucose turnover and lipid levels in obese children with fasting normoinsulinaemia .
7705803	0	glucose	132,139	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	-LSB-|nmod|START_ENTITY -LSB-|nsubj|secretion secretion|amod|END_ENTITY	Insulin secretion and plasma levels of glucose-dependent_insulinotropic_peptide and glucagon-like_peptide_1 -LSB- 7-36 amide -RSB- after oral glucose in cirrhosis .
7733259	0	glucose	40,47	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	transporters|compound|START_ENTITY translocation|nmod|transporters induces|dobj|translocation induces|nsubj|END_ENTITY	Insulin induces translocation of GLUT-4 glucose transporters in human skeletal muscle .
7840177	0	glucose	55,62	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	infusion|compound|START_ENTITY graded|dobj|infusion graded|nsubj|secretion secretion|compound|END_ENTITY	Insulin secretion and clearance during low-dose graded glucose infusion .
786634	0	glucose	18,25	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	transport|compound|START_ENTITY action|nmod|transport action|compound|END_ENTITY	Insulin action on glucose transport and calcium fluxes in developing muscle cells in vitro .
7877889	0	glucose	123,130	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY degrees|nmod|tolerance responses|nmod|degrees responses|compound|END_ENTITY	Insulin responses to intravenous glucose and the hyperglycemic clamp in cystic fibrosis patients with different degrees of glucose tolerance .
7877889	0	glucose	33,40	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	responses|nmod|START_ENTITY responses|compound|END_ENTITY	Insulin responses to intravenous glucose and the hyperglycemic clamp in cystic fibrosis patients with different degrees of glucose tolerance .
7901065	0	glucose	28,35	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	administration|compound|START_ENTITY responses|nmod|administration responses|compound|END_ENTITY	Insulin responses following glucose administration in menstruating women .
8027230	0	glucose	111,118	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	showing|nmod|START_ENTITY response|acl|showing response|compound|END_ENTITY	Insulin response to intravenous glucose in patients with anorexia_nervosa showing low insulin response to oral glucose .
8027230	0	glucose	32,39	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Insulin response to intravenous glucose in patients with anorexia_nervosa showing low insulin response to oral glucose .
8036449	0	glucose	37,44	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY levels|nmod|tolerance levels|compound|END_ENTITY	Insulin and PAI-1 levels during oral glucose tolerance test in patients with coronary_heart_disease .
8052138	0	glucose	28,35	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	cycling|compound|START_ENTITY dissociates|dobj|cycling dissociates|nsubj|END_ENTITY	Insulin dissociates hepatic glucose cycling and glucagon-induced thermogenesis in man .
8077319	0	glucose	44,51	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	Insulin secretion , clearance , and action on glucose metabolism in cirrhotic patients .
8077883	0	glucose	21,28	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	responses|nmod|START_ENTITY responses|compound|END_ENTITY	Insulin responses to glucose in healthy males are associated with adult height but not with birth weight .
8128180	0	glucose	18,25	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	transport|compound|START_ENTITY action|nmod|transport action|compound|END_ENTITY	Insulin action on glucose transport in isolated skeletal muscle from patients with liver_cirrhosis .
8139489	0	glucose	41,48	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	Insulin production following intravenous glucose , arginine , and valine : different pattern in patients with impaired_glucose_tolerance and non-insulin-dependent_diabetes_mellitus .
8200996	0	glucose	28,35	Insulin	0,7	glucose	Insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	metabolism|compound|START_ENTITY regulation|nmod|metabolism regulation|compound|END_ENTITY	Insulin regulation of renal glucose metabolism in conscious dogs .
8252839	0	glucose	26,33	Insulin	0,7	glucose	Insulin	MESH:D005947	280829(Tax:9913)	Chemical	Gene	responsiveness|compound|START_ENTITY responsiveness|nmod|responsiveness responsiveness|nsubj|END_ENTITY	Insulin responsiveness to glucose and tissue responsiveness to insulin during lactation in dairy cows .
8319140	0	glucose	22,29	Insulin	0,7	glucose	Insulin	MESH:D005947	493804(Tax:9685)	Chemical	Gene	response|compound|START_ENTITY resistance|nmod|response resistance|compound|END_ENTITY	Insulin resistance of glucose response produced by hepatic denervations .
8349044	0	glucose	66,73	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY determinants|nmod|tolerance determinants|nsubj|resistance resistance|compound|END_ENTITY	Insulin resistance and insulin secretion are determinants of oral glucose tolerance in normal individuals .
835136	0	glucose	20,27	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Insulin response to glucose or glucagon in subclinical diabetes previously injected with tolbutamide .
8366505	0	glucose	103,110	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	transport|compound|START_ENTITY regulation|nmod|transport receptors|dep|regulation receptors|compound|END_ENTITY	Insulin and IGE-1 receptors in a human intestinal_adenocarcinoma cell line -LRB- CACO-2 -RRB- : regulation of Na + glucose transport across the brush border .
8408513	0	glucose	112,119	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY augments|nmod|test augments|nsubj|END_ENTITY	Insulin hypersecretion together with high luteinizing hormone concentration augments androgen secretion in oral glucose tolerance test in women with polycystic_ovarian_disease .
8447386	0	glucose	80,87	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	transporters|compound|START_ENTITY expression|nmod|transporters resistance|dep|expression resistance|compound|END_ENTITY	Insulin resistance in polycystic_ovary_syndrome : decreased expression of GLUT-4 glucose transporters in adipocytes .
8580884	0	glucose	108,115	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	load|compound|START_ENTITY mean|nmod|load mean|nsubj|resistance resistance|compound|END_ENTITY	Insulin resistance and myocardial_hypertrophy in the attenuated reduction in mean arterial pressure after a glucose load in hypertensive patients .
8636267	0	glucose	66,73	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	utilization|compound|START_ENTITY defects|nmod|utilization resistance|dep|defects resistance|compound|END_ENTITY	Insulin resistance in growth hormone-deficient adults : defects in glucose utilization and glycogen synthase activity .
8636292	0	glucose	73,80	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	extraction|compound|START_ENTITY role|nmod|extraction resistance|dep|role resistance|compound|END_ENTITY	Insulin resistance in type_I_diabetes_mellitus : a major role for reduced glucose extraction .
8644011	0	glucose	69,76	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY metabolism|dep|test metabolism|compound|END_ENTITY	Insulin metabolism after relief of obstructive_jaundice : intravenous glucose tolerance test with portal blood sampling .
8695671	0	glucose	33,40	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY response|nmod|test response|compound|END_ENTITY	Insulin response during the oral glucose tolerance test : the role of age , sex , body fat and the pattern of fat distribution .
8746619	0	glucose	85,92	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY inhibitor|nmod|metabolism efficacy|nmod|inhibitor necessary|nmod|efficacy secretion|xcomp|necessary secretion|nsubj|END_ENTITY	Insulin secretion levels necessary for efficacy of an alpha-glucosidase inhibitor on glucose metabolism in patients with non-insulin-dependent_diabetes_mellitus .
8889763	0	glucose	26,33	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	utilization|compound|START_ENTITY limits|dobj|utilization limits|nsubj|resistance resistance|compound|END_ENTITY	Insulin resistance limits glucose utilization and exercise tolerance in myophosphorylase_deficiency and NIDDM .
8894494	0	glucose	25,32	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	load|compound|START_ENTITY response|nmod|load response|compound|END_ENTITY	Insulin response to oral glucose load is consistently decreased in established non-insulin-dependent_diabetes_mellitus : the usefulness of decreased early insulin response as a predictor of non-insulin-dependent_diabetes_mellitus .
8897005	0	glucose	18,25	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	transport|compound|START_ENTITY action|nmod|transport action|compound|END_ENTITY	Insulin action on glucose transport and plasma membrane GLUT4 content in skeletal muscle from patients with NIDDM .
8936961	0	glucose	51,58	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	provocation|nmod|START_ENTITY provocation|nsubj|responses responses|compound|END_ENTITY	Insulin and glucagon responses to provocation with glucose and arginine in prepubertal children with thalassemia major before and after long-term blood transfusion .
9030818	0	glucose	19,26	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	production|compound|START_ENTITY secretion|appos|production secretion|compound|END_ENTITY	Insulin secretion , glucose production , and insulin sensitivity in underweight and normal-weight volunteers , and in underweight and normal-weight cancer patients : a Clinical Research Center study .
9030825	0	glucose	21,28	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	effectiveness|compound|START_ENTITY sensitivity|appos|effectiveness sensitivity|compound|END_ENTITY	Insulin sensitivity , glucose effectiveness , and beta-cell function in obese males with essential hypertension : investigation of the effects of treatment with a calcium channel blocker -LRB- diltiazem -RRB- or an angiotensin-converting enzyme inhibitor -LRB- quinapril -RRB- .
9059765	0	glucose	33,40	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	responses|nmod|START_ENTITY responses|compound|END_ENTITY	Insulin responses to intravenous glucose , intravenous arginine and a hyperglycaemic clamp in ICA-positive subjects with different degrees of glucose_tolerance .
9109953	0	glucose	44,51	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	administration|compound|START_ENTITY response|nmod|administration response|compound|END_ENTITY	Insulin and glucose response following oral glucose administration in well-conditioned ponies .
9486168	0	glucose	27,34	Insulin	0,7	glucose	Insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	production|compound|START_ENTITY suppresses|dobj|production suppresses|nsubj|END_ENTITY	Insulin acutely suppresses glucose production by both peripheral and hepatic effects in normal dogs .
9486987	0	glucose	22,29	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	uptake|compound|START_ENTITY resistance|nmod|uptake resistance|compound|END_ENTITY	Insulin resistance of glucose uptake in skeletal muscle can not be ameliorated by enhancing endothelium-dependent blood flow in obesity .
9495639	0	glucose	151,158	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	technique|compound|START_ENTITY modifications|nmod|technique validation|nmod|modifications relates|dobj|validation relates|nsubj|sensitivity sensitivity|compound|END_ENTITY	Insulin sensitivity relates to other cardiovascular risk factors in young men : validation of some modifications of the hyperinsulinaemic , isoglycaemic glucose clamp technique .
954785	0	glucose	74,81	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY response|nmod|tolerance response|amod|END_ENTITY	Insulin response and portal-peripheral insulin difference during the oral glucose tolerance test in patients after abdominal operations .
9628273	0	glucose	33,40	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	uptake|compound|START_ENTITY characterizes|dobj|uptake characterizes|nsubj|resistance resistance|compound|END_ENTITY	Insulin resistance characterizes glucose uptake in skeletal muscle but not in the heart in NIDDM .
9744832	0	glucose	15,22	Insulin	0,7	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	levels|compound|START_ENTITY END_ENTITY|appos|levels	Insulin , blood glucose levels , and ischemic brain_damage .
98446	0	glucose	70,77	Insulin	1,8	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	-RSB-|compound|START_ENTITY infusion|nmod|-RSB- concentration|nmod|infusion concentration|nsubj|END_ENTITY	-LSB- Insulin concentration in polytraumatized patients during infusion of glucose , fructose and sorbitol -RSB- .
10487270	0	glucose	119,126	Insulin-like_growth_factor-1	0,28	glucose	Insulin-like growth factor-1	MESH:D005947	3479	Chemical	Gene	mediate|nmod|START_ENTITY mediate|nsubj|receptors receptors|amod|END_ENTITY	Insulin-like_growth_factor-1 receptors mediate infragenicular vascular smooth muscle cell proliferation in response to glucose and insulin not by insulin_receptors .
11145617	0	glucose	51,58	Insulin-like_growth_factor-1	0,28	glucose	Insulin-like growth factor-1	MESH:D005947	24482(Tax:10116)	Chemical	Gene	utilization|compound|START_ENTITY increases|dobj|utilization increases|nsubj|END_ENTITY	Insulin-like_growth_factor-1 selectively increases glucose utilization in brains of aged animals .
12065632	0	glucose	72,79	Insulin-like_growth_factor-1	0,28	glucose	Insulin-like growth factor-1	MESH:D005947	281239(Tax:9913)	Chemical	Gene	transport|compound|START_ENTITY effects|nmod|transport effects|amod|END_ENTITY	Insulin-like_growth_factor-1 effects on bovine retinal endothelial cell glucose transport : role of MAP kinase .
1717244	0	glucose	61,68	Insulin-like_growth_factor-binding_protein-1	0,44	glucose	Insulin-like growth factor-binding protein-1	MESH:D005947	3484	Chemical	Gene	levels|compound|START_ENTITY modulates|dobj|levels modulates|nsubj|END_ENTITY	Insulin-like_growth_factor-binding_protein-1 modulates blood glucose levels .
10954733	0	glucose	56,63	Insulin-like_growth_factor_1	0,28	glucose	Insulin-like growth factor 1	MESH:D005947	16000(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY regulates|dobj|metabolism regulates|nsubj|END_ENTITY	Insulin-like_growth_factor_1 regulates developing brain glucose metabolism .
10770216	0	glucose	120,127	Insulin-like_growth_factor_I	0,28	glucose	Insulin-like growth factor I	MESH:D005947	3479	Chemical	Gene	lipid|dep|START_ENTITY effects|nmod|lipid END_ENTITY|dep|effects	Insulin-like_growth_factor_I and growth_hormone -LRB- GH -RRB- treatment in GH-deficient humans : differential effects on protein , glucose , lipid , and calcium metabolism .
1770040	0	glucose	48,55	Insulin-like_growth_factor_I	0,28	glucose	Insulin-like growth factor I	MESH:D005947	3479	Chemical	Gene	uptake|compound|START_ENTITY stimulates|dobj|uptake stimulates|nsubj|END_ENTITY	Insulin-like_growth_factor_I -LRB- IGF-I -RRB- stimulates glucose and amino_acid uptake in cultured glomerular mesangial cells .
23592916	0	glucose	109,116	Insulin-like_growth_factor_binding_protein-3	0,44	glucose	Insulin-like growth factor binding protein-3	MESH:D005947	3486	Chemical	Gene	conditions|compound|START_ENTITY cells|nmod|conditions inhibits|nmod|cells inhibits|nsubj|END_ENTITY	Insulin-like_growth_factor_binding_protein-3 inhibits monocyte adhesion to retinal endothelial cells in high glucose conditions .
10329994	0	glucose	73,80	Insulin_receptor	0,16	glucose	Insulin receptor	MESH:D005947	3643	Chemical	Gene	disposal|compound|START_ENTITY correlates|nmod|disposal correlates|nsubj|autophosphorylation autophosphorylation|amod|END_ENTITY	Insulin_receptor autophosphorylation in cultured myoblasts correlates to glucose disposal in Pima Indians .
10573543	0	glucose	57,64	Insulin_receptor	0,16	glucose	Insulin receptor	MESH:D005947	16337(Tax:10090)	Chemical	Gene	meal|compound|START_ENTITY nucleus|nmod|meal END_ENTITY|nmod|nucleus	Insulin_receptor at the mouse hepatocyte nucleus after a glucose meal induces dephosphorylation of a 30-kDa transcription factor and a concomitant increase in malic enzyme gene expression .
25797178	0	glucose	103,110	Insulin_receptor	0,16	glucose	Insulin receptor	MESH:D005947	16337(Tax:10090)	Chemical	Gene	availability|compound|START_ENTITY enabling|dobj|availability cells|dep|enabling confers|nmod|cells confers|nsubj|A A|compound|END_ENTITY	Insulin_receptor isoform A confers a higher proliferative capability to pancreatic beta cells enabling glucose availability and IGF-I signaling .
2715185	0	glucose	29,36	Insulin_receptor	0,16	glucose	Insulin receptor	MESH:D005947	100766818	Chemical	Gene	transport|compound|START_ENTITY transport|compound|END_ENTITY	Insulin_receptor and altered glucose transport in a monensin-resistant mutant of Chinese_hamster_ovary cell .
3894420	0	glucose	92,99	Insulin_receptor	0,16	glucose	Insulin receptor	MESH:D005947	24954(Tax:10116)	Chemical	Gene	system|compound|START_ENTITY defect|nmod|system linked|nmod|defect linked|nsubjpass|down-regulation down-regulation|compound|END_ENTITY	Insulin_receptor down-regulation is linked to an insulin-induced postreceptor defect in the glucose transport system in rat adipocytes .
7000498	0	glucose	49,56	Insulin_receptor	0,16	glucose	Insulin receptor	MESH:D005947	24954(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	Insulin_receptor function and insulin effects on glucose metabolism in adipocytes from ventromedial hypothalamus-lesioned rats .
10409618	0	glucose	83,90	Insulin_receptor_substrate-2	0,28	glucose	Insulin receptor substrate-2	MESH:D005947	384783(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY necessary|nmod|transport necessary|nsubj|END_ENTITY	Insulin_receptor_substrate-2 is not necessary for insulin - and exercise-stimulated glucose transport in skeletal muscle .
20134186	0	glucose	21,28	Interleukin-1	0,13	glucose	Interleukin-1	MESH:D005947	3552	Chemical	Gene	homeostasis|compound|START_ENTITY homeostasis|amod|END_ENTITY	Interleukin-1 resets glucose homeostasis at central and peripheral levels : relevance for immunoregulation .
9550283	0	glucose	71,78	Interleukin-13	0,14	glucose	Interleukin-13	MESH:D005947	116553(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY interleukin-1beta|nmod|metabolism induced|nmod|interleukin-1beta suppression|acl|induced counteracts|dobj|suppression counteracts|nsubj|END_ENTITY	Interleukin-13 counteracts suppression induced by interleukin-1beta of glucose metabolism but not of insulin secretion in rat pancreatic islets .
2171911	0	glucose	155,162	Interleukin-1_beta	0,18	glucose	Interleukin-1 beta	MESH:D005947	16176(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY impairing|dobj|metabolism depletes|advcl|impairing depletes|nsubj|END_ENTITY	Interleukin-1_beta depletes insulin messenger ribonucleic acid and increases the heat_shock protein hsp70 in mouse pancreatic_islets without impairing the glucose metabolism .
8728164	0	glucose	30,37	Interleukin-1_beta	0,18	glucose	Interleukin-1 beta	MESH:D005947	3553	Chemical	Gene	uptake|compound|START_ENTITY stimulates|dobj|uptake stimulates|nsubj|END_ENTITY	Interleukin-1_beta stimulates glucose uptake of human peritoneal mesothelial cells in vitro .
26944557	0	glucose	29,36	Interleukin-1b	0,14	glucose	Interleukin-1b	MESH:D005947	3553	Chemical	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	Interleukin-1b mediates high glucose induced phenotypic transition in human aortic endothelial cells .
16837248	0	glucose	71,78	Interleukin-2	0,13	glucose	Interleukin-2	MESH:D005947	116562(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY induced|nmod|levels endothelial_dysfunction|acl|induced protects|nmod|endothelial_dysfunction protects|nsubj|END_ENTITY	Interleukin-2 protects against endothelial_dysfunction induced by high glucose levels in rats .
15220185	0	glucose	42,49	Interleukin-6	0,13	glucose	Interleukin-6	MESH:D005947	3569	Chemical	Gene	homeostasis|compound|START_ENTITY mediating|dobj|homeostasis factor|acl|mediating factor|nsubj|END_ENTITY	Interleukin-6 is a novel factor mediating glucose homeostasis during skeletal muscle contraction .
17003332	0	glucose	43,50	Interleukin-6	0,13	glucose	Interleukin-6	MESH:D005947	3569	Chemical	Gene	disposal|compound|START_ENTITY increases|dobj|disposal increases|nsubj|END_ENTITY	Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty_acid oxidation in vitro via AMP-activated protein kinase .
17363741	0	glucose	33,40	Interleukin-6	0,13	glucose	Interleukin-6	MESH:D005947	3569	Chemical	Gene	metabolism|compound|START_ENTITY increases|dobj|metabolism increases|nsubj|END_ENTITY	Interleukin-6 directly increases glucose metabolism in resting human skeletal muscle .
22706344	0	glucose	24,31	Interleukin-6	0,13	glucose	Interleukin-6	MESH:D005947	16193(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY maintains|dobj|homeostasis maintains|nsubj|END_ENTITY	Interleukin-6 maintains glucose homeostasis to support strenuous masseter muscle activity in mice .
24702712	0	glucose	72,79	Interleukin-6	0,13	glucose	Interleukin-6	MESH:D005947	3569	Chemical	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	Interleukin-6 in combination with the interleukin-6_receptor stimulates glucose uptake in resting human skeletal muscle independently of insulin action .
26808480	0	glucose	49,56	Interleukin-6	0,13	glucose	Interleukin-6	MESH:D005947	24498(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY regulator|nmod|production regulator|nsubj|END_ENTITY	Interleukin-6 is a negative regulator of hepatic glucose production in the isolated rat liver .
26842302	0	glucose	155,162	Interleukin-6	0,13	glucose	Interleukin-6	MESH:D005947	3569	Chemical	Gene	metabolism|compound|START_ENTITY parameters|nmod|metabolism surgery|nmod|parameters predicts|nmod|surgery predicts|nsubj|END_ENTITY	Interleukin-6 predicts inflammation-induced increase of Glucagon-like_peptide-1 in humans in response to cardiac surgery with association to parameters of glucose metabolism .
8645290	0	glucose	23,30	Interleukin-6	0,13	glucose	Interleukin-6	MESH:D005947	403985(Tax:9615)	Chemical	Gene	transport|compound|START_ENTITY enhances|dobj|transport enhances|nsubj|END_ENTITY	Interleukin-6 enhances glucose transport in 3T3-L1 adipocytes .
3318508	0	glucose	22,29	Interleukin_1	0,13	glucose	Interleukin 1	MESH:D005947	3552	Chemical	Gene	homeostasis|compound|START_ENTITY affects|dobj|homeostasis affects|nsubj|END_ENTITY	Interleukin_1 affects glucose homeostasis .
2105658	0	glucose	33,40	Interleukin_6	0,13	glucose	Interleukin 6	MESH:D005947	3569	Chemical	Gene	release|compound|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Interleukin_6 stimulates hepatic glucose release from prelabeled glycogen pools .
16957409	0	glucose	98,105	KLOTHO	81,87	glucose	KLOTHO	MESH:D005947	9365	Chemical	Gene	metabolism|compound|START_ENTITY G395A|nmod|metabolism G395A|nmod|promoter promoter|nmod|exon exon|nmod|gene gene|compound|END_ENTITY	Relationship between polymorphisms G395A in promoter and C1818T in exon 4 of the KLOTHO gene with glucose metabolism and cardiovascular risk factors in Korean women .
22206009	0	glucose	14,21	KSR1	37,41	glucose	KSR1	MESH:D005947	16706(Tax:10090)	Chemical	Gene	Regulation|nmod|START_ENTITY homeostasis|nsubj|Regulation homeostasis|nmod|END_ENTITY	Regulation of glucose homeostasis by KSR1 and MARK2 .
22319626	0	glucose	59,66	Klotho	0,6	glucose	Klotho	MESH:D005947	16591(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY role|nmod|homeostasis lacks|dobj|role lacks|nsubj|END_ENTITY	Klotho lacks a vitamin_D independent physiological role in glucose homeostasis , bone turnover , and steady-state PTH secretion in vivo .
26419931	0	glucose	117,124	Klotho	28,34	glucose	Klotho	MESH:D005947	83504(Tax:10116)	Chemical	Gene	cultured|nmod|START_ENTITY cells|acl|cultured regulating|nmod|cells regulating|nsubj|END_ENTITY	The function of miR-199a-5p / Klotho regulating TLR4/NF-kB p65/NGAL pathways in rat mesangial cells cultured with high glucose and the mechanism .
26806457	0	glucose	62,69	Klotho	52,58	glucose	Klotho	MESH:D005947	9365	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	Effect of systemically increasing human full-length Klotho on glucose metabolism in db/db mice .
359390	0	glucose	45,52	L-asparaginase	22,36	glucose	L-asparaginase	MESH:D005947	80150	Chemical	Gene	tolerance|compound|START_ENTITY effect|nmod|tolerance effect|nmod|END_ENTITY	The effect of E. _ coli L-asparaginase on oral glucose tolerance and insulin release in man .
12087089	0	glucose	34,41	L-pyruvate_kinase	68,85	glucose	L-pyruvate kinase	MESH:D005947	24651(Tax:10116)	Chemical	Gene	stimulation|compound|START_ENTITY stimulation|nmod|expression expression|amod|END_ENTITY	ChREBP rather than USF2 regulates glucose stimulation of endogenous L-pyruvate_kinase expression in insulin-secreting cells .
16308421	0	glucose	25,32	LKB1	11,15	glucose	LKB1	MESH:D005947	20869(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY mediates|dobj|homeostasis mediates|nsubj|END_ENTITY	The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin .
16966378	0	glucose	83,90	LKB1	38,42	glucose	LKB1	MESH:D005947	20869(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY improves|dobj|homeostasis improves|nsubj|knockout knockout|nmod|increases_insulin_sensitivity increases_insulin_sensitivity|compound|END_ENTITY	Skeletal muscle-selective knockout of LKB1 increases_insulin_sensitivity , improves glucose homeostasis , and decreases TRB3 .
17083919	0	glucose	41,48	LKB1	0,4	glucose	LKB1	MESH:D005947	20869(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY regulates|dobj|metabolism regulates|nsubj|END_ENTITY	LKB1 , an upstream AMPK kinase , regulates glucose and lipid metabolism in cultured liver and muscle cells .
20973294	0	glucose	102,109	LOX-1	189,194	glucose	LOX-1	MESH:D005947	4973	Chemical	Gene	concentration|compound|START_ENTITY exposed|nmod|concentration exposed|nmod|lectin-like_oxidized_low_density_lipoprotein_receptor-1 lectin-like_oxidized_low_density_lipoprotein_receptor-1|appos|END_ENTITY	Calcium channel blocker -LRB- diltiazem -RRB- inhibits apoptosis of vascular smooth muscle cell exposed to high glucose concentration through lectin-like_oxidized_low_density_lipoprotein_receptor-1 -LRB- LOX-1 -RRB- pathway .
23395167	0	glucose	14,21	LRP6	0,4	glucose	LRP6	MESH:D005947	4040	Chemical	Gene	metabolism|compound|START_ENTITY enhances|dobj|metabolism enhances|nsubj|END_ENTITY	LRP6 enhances glucose metabolism by promoting TCF7L2-dependent insulin_receptor expression and IGF receptor stabilization in humans .
17187055	0	glucose	30,37	LXR	21,24	glucose	LXR	MESH:D005947	22260(Tax:10090)	Chemical	Gene	sensor|compound|START_ENTITY sensor|nsubj|END_ENTITY	The nuclear receptor LXR is a glucose sensor .
15558076	0	glucose	100,107	Lep	118,121	glucose	Lep	MESH:D005947	16846(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|END_ENTITY	Effects of the cannabinoid CB1 receptor antagonist SR141716 on oxygen consumption and soleus muscle glucose uptake in Lep -LRB- ob -RRB- / Lep -LRB- ob -RRB- mice .
10389859	0	glucose	42,49	Leptin	0,6	glucose	Leptin	MESH:D005947	25608(Tax:10116)	Chemical	Gene	turnover|compound|START_ENTITY restores|dobj|turnover restores|nsubj|END_ENTITY	Leptin restores euglycemia and normalizes glucose turnover in insulin-deficient diabetes in the rat .
10411236	0	glucose	34,41	Leptin	0,6	glucose	Leptin	MESH:D005947	3952	Chemical	Gene	test|compound|START_ENTITY concentrations|nmod|test concentrations|compound|END_ENTITY	Leptin concentrations during oral glucose tolerance test -LRB- OGTT -RRB- in obese and normal weight women .
10484352	0	glucose	28,35	Leptin	0,6	glucose	Leptin	MESH:D005947	16846(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY effects|nmod|metabolism has|dobj|effects has|nsubj|END_ENTITY	Leptin has acute effects on glucose and lipid metabolism in both lean and gold thioglucose-obese mice .
10619403	0	glucose	18,25	Leptin	0,6	glucose	Leptin	MESH:D005947	16846(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY stimulates|dobj|uptake stimulates|nsubj|END_ENTITY	Leptin stimulates glucose uptake in C2C12 muscle cells by activation of ERK2 .
10670656	0	glucose	81,88	Leptin	0,6	glucose	Leptin	MESH:D005947	396832(Tax:9823)	Chemical	Gene	correlation|nmod|START_ENTITY endotoxemia|dep|correlation reduced|nmod|endotoxemia reduced|nsubjpass|expression expression|compound|END_ENTITY	Leptin expression is reduced with acute endotoxemia in the pig : correlation with glucose , insulin , and insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- .
11052964	0	glucose	20,27	Leptin	0,6	glucose	Leptin	MESH:D005947	25608(Tax:10116)	Chemical	Gene	responses|nmod|START_ENTITY responses|compound|END_ENTITY	Leptin responses to glucose infusions in obesity-prone rats .
11260392	0	glucose	71,78	Leptin	0,6	glucose	Leptin	MESH:D005947	3952	Chemical	Gene	uptake|compound|START_ENTITY production|dep|uptake stimulates|dobj|production stimulates|nsubj|END_ENTITY	Leptin stimulates type I collagen production in db/db mesangial cells : glucose uptake and TGF-beta_type_II_receptor expression .
11465644	0	glucose	55,62	Leptin	0,6	glucose	Leptin	MESH:D005947	3952	Chemical	Gene	loading|compound|START_ENTITY END_ENTITY|nmod|loading	Leptin and norepinephrine plasma concentrations during glucose loading in normotensive and hypertensive obese women .
12379472	0	glucose	16,23	Leptin	0,6	glucose	Leptin	MESH:D005947	3952	Chemical	Gene	proliferation|compound|START_ENTITY proliferation|compound|END_ENTITY	Leptin and high glucose stimulate cell proliferation in MCF-7 human breast_cancer cells : reciprocal involvement of PKC-alpha and PPAR expression .
15161768	0	glucose	61,68	Leptin	0,6	glucose	Leptin	MESH:D005947	3952	Chemical	Gene	homeostasis|compound|START_ENTITY polymorphisms|nmod|homeostasis polymorphisms|amod|END_ENTITY	Leptin and leptin_receptor gene polymorphisms and changes in glucose homeostasis in response to regular exercise in nondiabetic individuals : the HERITAGE family study .
16238186	0	glucose	24,31	Leptin	0,6	glucose	Leptin	MESH:D005947	3952	Chemical	Gene	tolerance|compound|START_ENTITY response|nmod|tolerance response|compound|END_ENTITY	Leptin response to oral glucose tolerance test in obese and nonobese premenopausal women .
16391424	0	glucose	34,41	Leptin	0,6	glucose	Leptin	MESH:D005947	280836(Tax:9913)	Chemical	Gene	uptake|compound|START_ENTITY influence|dobj|uptake seem|xcomp|influence seem|nsubj|END_ENTITY	Leptin does not seem to influence glucose uptake by bovine mammary explants .
21123564	0	glucose	24,31	Leptin	0,6	glucose	Leptin	MESH:D005947	16846(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY improves|dobj|homeostasis improves|nsubj|END_ENTITY	Leptin rapidly improves glucose homeostasis in obese mice by increasing hypothalamic_insulin_sensitivity .
21527729	0	glucose	49,56	Leptin	0,6	glucose	Leptin	MESH:D005947	3952	Chemical	Gene	metabolism|compound|START_ENTITY control|nmod|metabolism control|nsubj|END_ENTITY	Leptin and the central nervous system control of glucose metabolism .
24340098	0	glucose	16,23	Leptin	0,6	glucose	Leptin	MESH:D005947	3952	Chemical	Gene	absorption|compound|START_ENTITY inhibits|dobj|absorption inhibits|nsubj|END_ENTITY	Leptin inhibits glucose intestinal absorption via PKC , p38MAPK , PI3K and MEK/ERK .
25744051	0	glucose	33,40	Leptin	0,6	glucose	Leptin	MESH:D005947	3952	Chemical	Gene	homeostasis|compound|START_ENTITY searching|nmod|homeostasis 20years|acl|searching END_ENTITY|appos|20years	Leptin , 20years of searching for glucose homeostasis .
26035479	0	glucose	48,55	Leptin	0,6	glucose	Leptin	MESH:D005947	16846(Tax:10090)	Chemical	Gene	rhythmicity|nmod|START_ENTITY modulates|dobj|rhythmicity modulates|nsubj|END_ENTITY	Leptin modulates the daily rhythmicity of blood glucose .
26903647	0	glucose	27,34	Leptin	0,6	glucose	Leptin	MESH:D005947	3952	Chemical	Gene	homeostasis|compound|START_ENTITY regulates|dobj|homeostasis regulates|nsubj|signaling signaling|compound|END_ENTITY	Leptin signaling regulates glucose homeostasis , but not adipostasis , in the zebrafish .
9165231	0	glucose	18,25	Leptin	0,6	glucose	Leptin	MESH:D005947	16846(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY stimulates|dobj|transport stimulates|nsubj|END_ENTITY	Leptin stimulates glucose transport and glycogen synthesis in C2C12 myotubes : evidence for a P13-kinase mediated effect .
9809481	0	glucose	17,24	Leptin	0,6	glucose	Leptin	MESH:D005947	25608(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY increases|dobj|transport increases|nsubj|END_ENTITY	Leptin increases glucose transport and utilization in skeletal muscle in vitro .
9826213	0	glucose	33,40	Leptin	0,6	glucose	Leptin	MESH:D005947	25608(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY affect|dobj|metabolism affect|nsubj|END_ENTITY	Leptin does not affect adipocyte glucose metabolism : studies in fresh and cultured adipocytes .
9846176	0	glucose	52,59	Leptin	0,6	glucose	Leptin	MESH:D005947	25608(Tax:10116)	Chemical	Gene	incorporation|nmod|START_ENTITY inhibits|dobj|incorporation inhibits|nsubj|END_ENTITY	Leptin inhibits insulin-stimulated incorporation of glucose into lipids and stimulates glucose decarboxylation in isolated rat adipocytes .
21135134	0	glucose	23,30	Lipocalin-13	0,12	glucose	Lipocalin-13	MESH:D005947	227627(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY regulates|dobj|metabolism regulates|nsubj|END_ENTITY	Lipocalin-13 regulates glucose metabolism by both insulin-dependent and insulin-independent mechanisms .
21266325	0	glucose	68,75	Lkb1	12,16	glucose	Lkb1	MESH:D005947	20869(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY impairs|dobj|homeostasis impairs|nsubj|Deletion Deletion|nmod|END_ENTITY	Deletion of Lkb1 in pro-opiomelanocortin neurons impairs peripheral glucose homeostasis in mice .
11422736	0	glucose	5,12	MCP-1	21,26	glucose	MCP-1	MESH:D005947	6347	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	High glucose induces MCP-1 expression partly via tyrosine kinase-AP-1 pathway in peritoneal mesothelial cells .
19756411	0	glucose	18,25	MCP-l	36,41	glucose	MCP-l	MESH:D005947	4182	Chemical	Gene	stimulate|nsubj|START_ENTITY stimulate|dobj|END_ENTITY	Intermittent high glucose stimulate MCP-l , IL-18 , and PAI-1 , but inhibit adiponectin expression and secretion in adipocytes dependent of ROS .
23800176	0	glucose	102,109	MD-2	0,4	glucose	MD-2	MESH:D005947	23643	Chemical	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	MD-2 is involved in the stimulation of matrix metalloproteinase-1 expression by interferon-y and high glucose in mononuclear cells - a potential role of MD-2 in Toll-like_receptor_4-independent signalling .
23800176	0	glucose	102,109	MD-2	155,159	glucose	MD-2	MESH:D005947	23643	Chemical	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	MD-2 is involved in the stimulation of matrix metalloproteinase-1 expression by interferon-y and high glucose in mononuclear cells - a potential role of MD-2 in Toll-like_receptor_4-independent signalling .
18586252	0	glucose	5,12	MMP-1	60,65	glucose	MMP-1	MESH:D005947	4312	Chemical	Gene	stimulate|nsubj|START_ENTITY stimulate|dobj|expression expression|compound|END_ENTITY	High glucose and interferon_gamma synergistically stimulate MMP-1 expression in U937 macrophages by increasing transcription factor STAT1 activity .
12554125	0	glucose	210,217	MMP-2	191,196	glucose	MMP-2	MESH:D005947	4313	Chemical	Gene	deprivation|compound|START_ENTITY elevated|nmod|deprivation elevated|dobj|secretion secretion|compound|END_ENTITY	Molecular characterization and partial cDNA cloning of facilitative glucose_transporters expressed in human articular chondrocytes ; stimulation of 2-deoxyglucose uptake by IGF-I and elevated MMP-2 secretion by glucose deprivation .
17203468	0	glucose	25,32	MMP-2	36,41	glucose	MMP-2	MESH:D005947	4313	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Opposite effects of high glucose on MMP-2 and TIMP-2 in human endothelial cells .
17692316	0	glucose	5,12	MMP-2	22,27	glucose	MMP-2	MESH:D005947	4313	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|compound|END_ENTITY	High glucose enhances MMP-2 production in adventitial fibroblasts via Akt1-dependent NF-kappaB pathway .
22835601	0	glucose	94,101	MMP-2	28,33	glucose	MMP-2	MESH:D005947	4313	Chemical	Gene	transporter-1|compound|START_ENTITY Hep-2|nmod|transporter-1 Hep-2|nsubj|Effect Effect|nmod|expression expression|nmod|MT-MMP MT-MMP|compound|END_ENTITY	Effect on the expression of MMP-2 , MT-MMP in laryngeal_carcinoma Hep-2 cell line by antisense glucose transporter-1 .
24472542	0	glucose	57,64	Macrophage_migration_inhibitory_factor	0,38	glucose	Macrophage migration inhibitory factor	MESH:D005947	17319(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY diminishes|dobj|transport diminishes|nsubj|END_ENTITY	Macrophage_migration_inhibitory_factor diminishes muscle glucose transport induced by insulin and AICAR in a muscle type-dependent manner .
26455966	0	glucose	68,75	Macrophage_migration_inhibitory_factor	0,38	glucose	Macrophage migration inhibitory factor	MESH:D005947	17319(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY expression|nmod|transporter promotes|dobj|expression promotes|nsubj|END_ENTITY	Macrophage_migration_inhibitory_factor promotes expression of GLUT4 glucose transporter through MEF2 and Zac1 in cardiomyocytes .
25738901	0	glucose	29,36	MicroRNA-21	0,11	glucose	MicroRNA-21	MESH:D005947	406991	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	MicroRNA-21 , induced by high glucose , modulates macrophage apoptosis via programmed_cell_death_4 .
23716591	0	glucose	22,29	MicroRNA_33	0,11	glucose	MicroRNA 33	MESH:D005947	407039	Chemical	Gene	metabolism|compound|START_ENTITY regulates|dobj|metabolism regulates|nsubj|END_ENTITY	MicroRNA_33 regulates glucose metabolism .
25594850	0	glucose	25,32	Mig-6	8,13	glucose	Mig-6	MESH:D005947	74155(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY Role|nmod|metabolism Role|nmod|END_ENTITY	Role of Mig-6 in hepatic glucose metabolism .
11949851	0	glucose	106,113	Milk	0,4	glucose	Milk	MESH:D005947	100532204	Chemical	Gene	concentration|nmod|START_ENTITY gland|nmod|concentration gland|nsubj|response response|compound|END_ENTITY	Milk synthetic response of the bovine mammary gland to an increase in the local concentration of arterial glucose .
20542118	0	glucose	75,82	Monocyte_Chemoattractant_Protein-1	21,55	glucose	Monocyte Chemoattractant Protein-1	MESH:D005947	24770(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Quercetin attenuates Monocyte_Chemoattractant_Protein-1 gene expression in glucose primed aortic endothelial cells through NF-kappaB and AP-1 .
21127070	0	glucose	16,23	Myo1c	0,5	glucose	Myo1c	MESH:D005947	17913(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY regulates|dobj|uptake regulates|nsubj|END_ENTITY	Myo1c regulates glucose uptake in mouse skeletal muscle .
16464946	0	glucose	54,61	Myostatin	0,9	glucose	Myostatin	MESH:D005947	2660	Chemical	Gene	uptake|compound|START_ENTITY regulates|dobj|uptake product|acl:relcl|regulates product|nsubj|END_ENTITY	Myostatin is a human placental product that regulates glucose uptake .
17711997	0	glucose	20,27	Myostatin	0,9	glucose	Myostatin	MESH:D005947	2660	Chemical	Gene	uptake|compound|START_ENTITY regulates|dobj|uptake regulates|nsubj|END_ENTITY	Myostatin regulates glucose uptake in BeWo cells .
20887798	0	glucose	20,27	Myostatin	0,9	glucose	Myostatin	MESH:D005947	2660	Chemical	Gene	metabolism|compound|START_ENTITY regulates|dobj|metabolism regulates|nsubj|END_ENTITY	Myostatin regulates glucose metabolism via the AMP-activated protein kinase pathway in skeletal muscle cells .
24882465	0	glucose	56,63	Myostatin	0,9	glucose	Myostatin	MESH:D005947	17700(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY inhibits|dobj|uptake inhibits|nsubj|END_ENTITY	Myostatin inhibits proliferation and insulin-stimulated glucose uptake in mouse liver cells .
26568303	0	glucose	17,24	NAMPT	0,5	glucose	NAMPT	MESH:D005947	10135	Chemical	Gene	stress|nummod|START_ENTITY suppresses|dobj|stress suppresses|nsubj|END_ENTITY	NAMPT suppresses glucose deprivation-induced oxidative stress by increasing NADPH levels in breast_cancer .
24636131	4	glucose	657,664	NDRG2	648,653	glucose	GLUT1	MESH:D005947	6513	Chemical	Gene	uptake|compound|START_ENTITY END_ENTITY|nmod|uptake	The effects of NDRG2 on glucose uptake were assessed in breast_cancer cells and xenograft tumours .
14644391	0	glucose	5,12	NF-kappaB	21,30	glucose	NF-kappaB	MESH:D005947	4790	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	High glucose induced NF-kappaB DNA-binding activity in HAEC is maintained under low shear stress but inhibited under high shear stress : role of nitric_oxide .
24557342	0	glucose	5,12	NHE-1	38,43	glucose	NHE-1	MESH:D005947	478171(Tax:9615)	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	High glucose concentration stimulates NHE-1 activity in distal nephron cells : the role of the Mek/Erk1/2 / p90RSK and p38MAPK signaling pathways .
26205492	0	glucose	40,47	NUCKS	13,18	glucose	NUCKS	MESH:D005947	98415(Tax:10090)	Chemical	Gene	homoeostasis|compound|START_ENTITY regulates|dobj|homoeostasis regulates|nsubj|END_ENTITY	Hypothalamic NUCKS regulates peripheral glucose homoeostasis .
23342086	0	glucose	96,103	Nampt	18,23	glucose	Nampt	MESH:D005947	10135	Chemical	Gene	survival|nmod|START_ENTITY effect|nmod|survival have|dobj|effect have|nsubj|END_ENTITY	The adipocytokine Nampt and its product NMN have no effect on beta-cell survival but potentiate glucose stimulated insulin secretion .
21606541	0	glucose	13,20	Nef	0,3	glucose	Nef	MESH:D005947	6285	Chemical	Gene	uptake|compound|START_ENTITY inhibits|dobj|uptake inhibits|nsubj|END_ENTITY	Nef inhibits glucose uptake in adipocytes and contributes to insulin resistance in human_immunodeficiency_virus_type_I_infection .
9607814	0	glucose	28,35	Neuropeptide_Y	0,14	glucose	Neuropeptide Y	MESH:D005947	24604(Tax:10116)	Chemical	Gene	lowers|dobj|START_ENTITY lowers|nsubj|END_ENTITY	Neuropeptide_Y lowers blood glucose in anaesthetized rats via a Y5_receptor subtype .
44873	0	glucose	21,28	Neurotensin	0,11	glucose	Neurotensin	MESH:D005947	299757(Tax:10116)	Chemical	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Neurotensin inhibits glucose but not glucagon-induced insulin and somatostatin release in isolated islets .
20858221	0	glucose	25,32	Nhx1p	102,107	glucose	Nhx1p	MESH:D005947	852066(Tax:4932)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Saccharomyces_cerevisiae glucose signalling regulator Mth1p regulates the organellar Na + / H + exchanger Nhx1p .
24120946	0	glucose	24,31	Nucleoredoxin	0,13	glucose	Nucleoredoxin	MESH:D005947	64359	Chemical	Gene	metabolism|compound|START_ENTITY regulates|dobj|metabolism regulates|nsubj|END_ENTITY	Nucleoredoxin regulates glucose metabolism via phosphofructokinase_1 .
18420577	0	glucose	50,57	O-GlcNAc	0,8	glucose	O-GlcNAc	MESH:D005947	8473	Chemical	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	O-GlcNAc regulates FoxO activation in response to glucose .
25902163	0	glucose	16,23	OPG	41,44	glucose	OPG	MESH:D005947	25341(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effects of high glucose on expression of OPG and RANKL in rat aortic vascular smooth muscle cells .
21505958	0	glucose	20,27	Orexin_A	0,8	glucose	Orexin A	MESH:D005947	25723(Tax:10116)	Chemical	Gene	accumulation|compound|START_ENTITY stimulates|dobj|accumulation stimulates|nsubj|END_ENTITY	Orexin_A stimulates glucose uptake , lipid accumulation and adiponectin secretion from 3T3-L1 adipocytes and isolated primary rat adipocytes .
25930995	0	glucose	75,82	Osteocalcin	0,11	glucose	Osteocalcin	MESH:D005947	81613(Tax:10116)	Chemical	Gene	conditions|compound|START_ENTITY protects|nmod|conditions protects|nsubj|END_ENTITY	Osteocalcin protects pancreatic beta cell function and survival under high glucose conditions .
25310823	0	glucose	42,49	Osteopontin	0,11	glucose	Osteopontin	MESH:D005947	6696	Chemical	Gene	transporters|compound|START_ENTITY expression|nmod|transporters upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Osteopontin upregulates the expression of glucose transporters in osteosarcoma cells .
20034466	0	glucose	37,44	P-selectin	48,58	glucose	P-selectin	MESH:D005947	6403	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Similar effects of resistin and high glucose on P-selectin and fractalkine expression and monocyte adhesion in human endothelial cells .
27040307	0	glucose	40,47	P21-activated_kinase_2	0,22	glucose	P21-activated kinase 2	MESH:D005947	5062	Chemical	Gene	uptake|compound|START_ENTITY regulates|dobj|uptake regulates|nsubj|END_ENTITY	P21-activated_kinase_2 -LRB- PAK2 -RRB- regulates glucose uptake and insulin sensitivity in neuronal cells .
11108278	0	glucose	15,22	P38	73,76	glucose	P38	MESH:D005947	81649(Tax:10116)	Chemical	Gene	levels|nmod|START_ENTITY stimulate|nsubj|levels stimulate|dobj|expression expression|nmod|kinase kinase|compound|END_ENTITY	High levels of glucose stimulate angiotensinogen gene expression via the P38 mitogen-activated protein kinase pathway in rat kidney proximal tubular cells .
10503772	0	glucose	52,59	PACAP	15,20	glucose	PACAP	MESH:D005947	11516(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY potentiates|dobj|uptake potentiates|nsubj|END_ENTITY	Insulinotropin PACAP potentiates insulin-stimulated glucose uptake in 3T3 L1 cells .
10938228	0	glucose	53,60	PACAP	0,5	glucose	PACAP	MESH:D005947	11516(Tax:10090)	Chemical	Gene	gavage|compound|START_ENTITY contributes|nmod|gavage contributes|nsubj|END_ENTITY	PACAP contributes to insulin secretion after gastric glucose gavage in mice .
11193831	0	glucose	53,60	PACAP	16,21	glucose	PACAP	MESH:D005947	24166(Tax:10116)	Chemical	Gene	decreases|dobj|START_ENTITY decreases|nsubj|administration administration|compound|END_ENTITY	Intraperitoneal PACAP administration decreases blood glucose in GK rats , and in normal and high fat diet mice .
11193872	0	glucose	44,51	PACAP	0,5	glucose	PACAP	MESH:D005947	116	Chemical	Gene	manner|compound|START_ENTITY alpha-cells|nmod|manner activates|dobj|alpha-cells activates|nsubj|END_ENTITY	PACAP activates pancreatic alpha-cells in a glucose independent manner .
15056942	0	glucose	49,56	PACAP	40,45	glucose	PACAP	MESH:D005947	11516(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	-LSB- Physiological and therapeutic roles of PACAP in glucose metabolism and diabetes -RSB- .
17430174	0	glucose	13,20	PACAP	0,5	glucose	PACAP	MESH:D005947	116	Chemical	Gene	homeostasis|compound|START_ENTITY END_ENTITY|nmod|homeostasis	PACAP in the glucose and energy homeostasis : physiological role and therapeutic potential .
22477644	0	glucose	31,38	PACAP	109,114	glucose	PACAP	MESH:D005947	11516(Tax:10090)	Chemical	Gene	levels|compound|START_ENTITY recovery|nmod|levels fed|nsubj|recovery fed|dobj|diet diet|dep|effects effects|nmod|overexpression overexpression|compound|END_ENTITY	Compensatory recovery of blood glucose levels in KKA -LRB- y -RRB- mice fed a high-fat diet : insulin-sparing effects of PACAP overexpression in b cells .
7716074	0	glucose	17,24	PACAP	0,5	glucose	PACAP	MESH:D005947	24166(Tax:10116)	Chemical	Gene	output|compound|START_ENTITY stimulates|dobj|output stimulates|nsubj|END_ENTITY	PACAP stimulates glucose output from the perfused rat liver .
11440364	0	glucose	72,79	PAI-1	148,153	glucose	PAI-1	MESH:D005947	5054	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Transcription factor decoy for activator_protein-1 -LRB- AP-1 -RRB- inhibits high glucose - and angiotensin_II-induced type 1 plasminogen activator inhibitor -LRB- PAI-1 -RRB- gene expression in cultured human vascular smooth muscle cells .
12181379	0	glucose	10,17	PAI-1	38,43	glucose	PAI-1	MESH:D005947	5054	Chemical	Gene	status|compound|START_ENTITY status|nmod|levels levels|compound|END_ENTITY	Effect of glucose tolerance status on PAI-1 plasma levels in overweight and obese subjects .
14550286	0	glucose	39,46	PAI-1	15,20	glucose	PAI-1	MESH:D005947	5054	Chemical	Gene	Stimulation|nmod|START_ENTITY Stimulation|nmod|END_ENTITY	Stimulation of PAI-1 and adipokines by glucose in human adipose tissue in vitro .
16911627	0	glucose	16,23	PAI-1	44,49	glucose	PAI-1	MESH:D005947	5054	Chemical	Gene	concentrations|compound|START_ENTITY Relationship|nmod|concentrations Relationship|nmod|END_ENTITY	Relationship of glucose concentrations with PAI-1 and t-PA in subjects with normal glucose tolerance .
16911627	0	glucose	83,90	PAI-1	44,49	glucose	PAI-1	MESH:D005947	5054	Chemical	Gene	tolerance|compound|START_ENTITY subjects|nmod|tolerance Relationship|nmod|subjects Relationship|nmod|END_ENTITY	Relationship of glucose concentrations with PAI-1 and t-PA in subjects with normal glucose tolerance .
20530060	0	glucose	16,23	PAI-1	74,79	glucose	PAI-1	MESH:D005947	5054	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of high glucose and ketosis -LRB- acetoacetate , ss-hydroxybutyrate -RRB- on PAI-1 secretion in human umbilical vascular endothelial cells .
21624046	0	glucose	96,103	PAI-1	19,24	glucose	PAI-1	MESH:D005947	5054	Chemical	Gene	regulation|compound|START_ENTITY associated|nmod|regulation associated|nsubjpass|levels levels|nmod|activity activity|compound|END_ENTITY	Elevated levels of PAI-1 activity and t-PA antigen are associated with newly diagnosed abnormal glucose regulation in patients with ST-elevation_myocardial_infarction .
26391252	12	glucose	1729,1736	PAI-1	1697,1702	glucose	PAI-1	MESH:D005947	18787(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl:relcl|induced	Gemigliptin and PAI-1 siRNA significantly inhibited pericyte apoptosis by inhibiting the overexpression of PAI-1 , which is induced by high glucose .
8440711	0	glucose	121,128	PC3	65,68	glucose	PC3	MESH:D005947	25204(Tax:10116)	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|biosynthesis biosynthesis|nmod|END_ENTITY	The biosynthesis of the subtilisin-related proprotein convertase PC3 , but no that of the PC2 convertase , is regulated by glucose in parallel to proinsulin biosynthesis in rat pancreatic islets .
11423476	0	glucose	9,16	PDX-1	102,107	glucose	PDX-1	MESH:D005947	18609(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Improved glucose tolerance and acinar_dysmorphogenesis by targeted expression of transcription factor PDX-1 to the exocrine pancreas .
26865911	0	glucose	47,54	PEPCK	110,115	glucose	PEPCK	MESH:D005947	362282(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY regulates|dobj|levels regulates|nmod|phosphoenolpyruvate_carboxylase phosphoenolpyruvate_carboxylase|appos|END_ENTITY	D-Xylose as a sugar complement regulates blood glucose levels by suppressing phosphoenolpyruvate_carboxylase -LRB- PEPCK -RRB- in streptozotocin-nicotinamide-induced diabetic rats and by enhancing glucose uptake in vitro .
9070246	0	glucose	17,24	PEPCK	69,74	glucose	PEPCK	MESH:D005947	362282(Tax:10116)	Chemical	Gene	modifies|nsubj|START_ENTITY modifies|dobj|expression expression|amod|phosphoenolpyruvate_carboxykinase phosphoenolpyruvate_carboxykinase|dep|END_ENTITY	Maternal dietary glucose modifies phosphoenolpyruvate_carboxykinase -LRB- PEPCK -RRB- gene expression in the kidney of newborn rats .
9727036	0	glucose	61,68	PEPCK	36,41	glucose	PEPCK	MESH:D005947	362282(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	The repression of hormone-activated PEPCK gene expression by glucose is insulin-independent but requires glucose metabolism .
23086035	0	glucose	16,23	PGC-1a	0,6	glucose	PGC-1a	MESH:D005947	10891	Chemical	Gene	homeostasis|compound|START_ENTITY improves|dobj|homeostasis improves|nsubj|END_ENTITY	PGC-1a improves glucose homeostasis in skeletal muscle in an activity-dependent manner .
27094040	0	glucose	8,15	PGC-1a	0,6	glucose	PGC-1a	MESH:D005947	10891	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|appos|metabolism	PGC-1a , glucose metabolism and type_2_diabetes_mellitus .
12807885	0	glucose	39,46	PGC-1beta	0,9	glucose	PGC-1beta	MESH:D005947	291567(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	PGC-1beta in the regulation of hepatic glucose and energy metabolism .
19507278	2	glucose	845,852	PHC	819,822	glucose	CD4	MESH:D005947	12504(Tax:10090)	Chemical	Gene	concentrations|compound|START_ENTITY END_ENTITY|nmod|concentrations	The effects of PHC on postprandial blood glucose concentrations , plasmatic insulin levels , morphology of pancreatic beta cells and CD4 -LRB- + -RRB- T cells proliferation after 28-day treatment were monitored .
21981974	0	glucose	32,39	PHGDH	0,5	glucose	PHGDH	MESH:D005947	26227	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|dobj|metabolism	PHGDH amplification and altered glucose metabolism in human melanoma .
23355380	0	glucose	69,76	PI3K	97,101	glucose	PI3K	MESH:D005947	298947(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|END_ENTITY	Propolis extract promotes translocation of glucose transporter 4 and glucose uptake through both PI3K - and AMPK-dependent pathways in skeletal muscle .
11779150	0	glucose	5,12	PKC_and_ERK	41,52	glucose	PKC and ERK	MESH:D005947	26413(Tax:10090)	Chemical	Gene	induced|nsubj|START_ENTITY induced|dobj|expression expression|nmod|END_ENTITY	High glucose induced VEGF expression via PKC_and_ERK in glomerular podocytes .
8256514	0	glucose	30,37	PMA1	51,55	glucose	PMA1	MESH:D005947	852876(Tax:4932)	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Transcriptional regulation by glucose of the yeast PMA1 gene encoding the plasma membrane H -LRB- + -RRB- - ATPase .
25038454	0	glucose	25,32	PME-1	71,76	glucose	PME-1	MESH:D005947	361613(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|END_ENTITY	Carnosic_acid stimulates glucose uptake in skeletal muscle cells via a PME-1 / PP2A/PKB signalling axis .
22338072	0	glucose	23,30	PNPLA3	0,6	glucose	PNPLA3	MESH:D005947	80339	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	PNPLA3 is regulated by glucose in human hepatocytes , and its I148M mutant slows down triglyceride hydrolysis .
23758436	0	glucose	30,37	PPAR-a	10,16	glucose	PPAR-a	MESH:D005947	19013(Tax:10090)	Chemical	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Impact of PPAR-a induction on glucose homoeostasis in alcohol-fed mice .
15113752	0	glucose	19,26	PPAR-gamma	54,64	glucose	PPAR-gamma	MESH:D005947	5468	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	The effect of high glucose and PPAR-gamma agonists on PPAR-gamma expression and function in HK-2 cells .
17389706	0	glucose	56,63	PPAR-gamma	15,25	glucose	PPAR-gamma	MESH:D005947	19016(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY attenuates|dobj|uptake attenuates|nsubj|Suppression Suppression|nmod|END_ENTITY	Suppression of PPAR-gamma attenuates insulin-stimulated glucose uptake by affecting both GLUT1 and GLUT4 in 3T3-L1 adipocytes .
12176975	0	glucose	106,113	PPARalpha	50,59	glucose	PPARalpha	MESH:D005947	19013(Tax:10090)	Chemical	Gene	production|compound|START_ENTITY utilization|nmod|production substrate|dobj|utilization substrate|nsubj|influences influences|appos|END_ENTITY	Peroxisome_proliferator-activated_receptor_alpha -LRB- PPARalpha -RRB- influences substrate utilization for hepatic glucose production .
16054078	0	glucose	50,57	PPARalpha	28,37	glucose	PPARalpha	MESH:D005947	19013(Tax:10090)	Chemical	Gene	maintain|dobj|START_ENTITY activates|xcomp|maintain activates|dobj|END_ENTITY	`` New '' hepatic fat activates PPARalpha to maintain glucose , lipid , and cholesterol homeostasis .
16509812	0	glucose	32,39	PPARalpha	11,20	glucose	PPARalpha	MESH:D005947	5465	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	Effects of PPARalpha on cardiac glucose metabolism : a transcriptional equivalent of the glucose-fatty_acid cycle ?
16278250	0	glucose	53,60	PPARdelta	0,9	glucose	PPARdelta	MESH:D005947	5467	Chemical	Gene	transport|compound|START_ENTITY effect|nmod|transport has|dobj|effect has|nsubj|GW-501516 GW-501516|compound|END_ENTITY	PPARdelta activator GW-501516 has no acute effect on glucose transport in skeletal muscle .
16492734	0	glucose	20,27	PPARdelta	0,9	glucose	PPARdelta	MESH:D005947	19015(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY regulates|dobj|metabolism regulates|nsubj|END_ENTITY	PPARdelta regulates glucose metabolism and insulin sensitivity .
18772483	0	glucose	10,17	PPARdelta	89,98	glucose	PPARdelta	MESH:D005947	19015(Tax:10090)	Chemical	Gene	tolerance|compound|START_ENTITY tolerance|nmod|mice mice|acl|transplanted transplanted|dep|END_ENTITY	Preserved glucose tolerance in high-fat-fed C57BL/6 mice transplanted with PPARgamma - / - , PPARdelta - / - , PPARgammadelta - / - , or LXRalphabeta - / - bone marrow .
20107107	4	glucose	854,861	PPARdelta	837,846	glucose	PPARdelta	MESH:D005947	5467	Chemical	Gene	system|compound|START_ENTITY END_ENTITY|nmod|system	RESEARCH DESIGN AND METHODS : Effects of 4-HDDE and PPARdelta on the glucose transport system and calreticulin expression in primary bovine aortic endothelial cells were evaluated by pharmacological and molecular interventions .
20739195	0	glucose	56,63	PPARy	24,29	glucose	PPARy	MESH:D005947	5468	Chemical	Gene	lower|dobj|START_ENTITY lower|nsubj|modulation modulation|nmod|activity activity|compound|END_ENTITY	Selective modulation of PPARy activity can lower plasma glucose without typical thiazolidinedione side-effects in patients with Type 2 diabetes .
21437157	0	glucose	21,28	PPARy	0,5	glucose	PPARy	MESH:D005947	5468	Chemical	Gene	agonist|nmod|START_ENTITY agonist|advmod|END_ENTITY	PPARy agonist beyond glucose lowering effect .
19267880	0	glucose	70,77	PREB	0,4	glucose	PREB	MESH:D005947	58842(Tax:10116)	Chemical	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	PREB regulates transcription of pancreatic glucokinase in response to glucose and cAMP .
21953448	0	glucose	93,100	PTEN	159,163	glucose	PTEN	MESH:D005947	5728	Chemical	Gene	utilization|compound|START_ENTITY utilization|acl|inhibiting inhibiting|dobj|protein protein|appos|END_ENTITY	Hydrogen_sulfide and L-cysteine increase phosphatidylinositol_3 ,4,5 - trisphosphate -LRB- PIP3 -RRB- and glucose utilization by inhibiting phosphatase and tensin homolog -LRB- PTEN -RRB- protein and activating phosphoinositide_3-kinase -LRB- PI3K -RRB- / serine/threonine protein kinase -LRB- AKT -RRB- / protein kinase C / -LRB- PKC / -RRB- in 3T3l1 adipocytes .
21539443	0	glucose	18,25	PTH	34,37	glucose	PTH	MESH:D005947	5741	Chemical	Gene	load|compound|START_ENTITY load|nmod|END_ENTITY	Effect of an oral glucose load on PTH , 250HD3 , calcium , and phosphorus homeostasis in postmenopausal women .
25827255	0	glucose	47,54	PTH	23,26	glucose	PTH	MESH:D005947	5741	Chemical	Gene	treatment|nmod|START_ENTITY treatment|compound|END_ENTITY	Effect of intermittent PTH treatment on plasma glucose in osteoporosis : A randomized trial .
16962947	0	glucose	40,47	PTHrP	0,5	glucose	PTHrP	MESH:D005947	5744	Chemical	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	PTHrP and insulin levels following oral glucose and calcium administration .
15699041	0	glucose	76,83	PTP1B	48,53	glucose	PTP1B	MESH:D005947	19246(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY homeostasis|appos|END_ENTITY	Liver-specific protein-tyrosine_phosphatase_1B -LRB- PTP1B -RRB- re-expression alters glucose homeostasis of PTP1B - / - mice .
15699041	0	glucose	76,83	PTP1B	99,104	glucose	PTP1B	MESH:D005947	19246(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY homeostasis|nmod|END_ENTITY	Liver-specific protein-tyrosine_phosphatase_1B -LRB- PTP1B -RRB- re-expression alters glucose homeostasis of PTP1B - / - mice .
23138128	0	glucose	58,65	PTP1B	31,36	glucose	PTP1B	MESH:D005947	19246(Tax:10090)	Chemical	Gene	levels|compound|START_ENTITY reduces|dobj|levels reduces|nsubj|delivery delivery|nmod|shRNA shRNA|compound|END_ENTITY	Hydrodynamic-based delivery of PTP1B shRNA reduces plasma glucose levels in diabetic mice .
24548753	3	glucose	445,452	PTP1B	494,499	glucose	PPARy	MESH:D005947	5468	Chemical	Gene	uptake|compound|START_ENTITY uptake|appos|inhibition inhibition|appos|END_ENTITY	We investigated the hypoglycemic effect of a methanolic Juglans regia leaf extract on glucose uptake , protein_tyrosine_phosphatase_1B -LRB- PTP1B -RRB- inhibition and peroxisome_proliferator-activated_receptor_gamma -LRB- PPARy -RRB- activation .
19056893	0	glucose	23,30	PVHL	0,4	glucose	PVHL	MESH:D005947	22346(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY regulator|nmod|metabolism regulator|nsubj|END_ENTITY	PVHL is a regulator of glucose metabolism and insulin secretion in pancreatic beta cells .
19034419	0	glucose	30,37	Paired_box_6	0,12	glucose	Paired box 6	MESH:D005947	5080	Chemical	Gene	metabolism|compound|START_ENTITY regulates|dobj|metabolism regulates|nsubj|END_ENTITY	Paired_box_6 -LRB- PAX6 -RRB- regulates glucose metabolism via proinsulin processing mediated by prohormone_convertase_1 / 3 -LRB- PC1/3 -RRB- .
3294051	0	glucose	41,48	Pancreatic_polypeptide	1,23	glucose	Pancreatic polypeptide	MESH:D005947	5539	Chemical	Gene	load|compound|START_ENTITY response|nmod|load response|compound|END_ENTITY	-LSB- Pancreatic_polypeptide response to oral glucose load in patients with liver_cirrhosis -- interrelationship between PP and other pancreatic endocrine hormones -RSB- .
6883762	0	glucose	49,56	Pancreatic_polypeptide	1,23	glucose	Pancreatic polypeptide	MESH:D005947	490944(Tax:9615)	Chemical	Gene	responses|nmod|START_ENTITY responses|compound|END_ENTITY	-LSB- Pancreatic_polypeptide responses to intravenous glucose and amino_acids administration in dogs -RSB- .
8855802	0	glucose	56,63	Pancreatic_polypeptide	0,22	glucose	Pancreatic polypeptide	MESH:D005947	5539	Chemical	Gene	metabolism|compound|START_ENTITY improves|dobj|metabolism improves|nsubj|administration administration|amod|END_ENTITY	Pancreatic_polypeptide administration improves abnormal glucose metabolism in patients with chronic pancreatitis .
7004878	0	glucose	38,45	Parathyroid_hormone_and_calcitonin	0,34	glucose	Parathyroid hormone and calcitonin	MESH:D005947	5741	Chemical	Gene	regulation|compound|START_ENTITY END_ENTITY|nmod|regulation	Parathyroid_hormone_and_calcitonin in glucose regulation .
1747930	0	glucose	11,18	PhIP	39,43	glucose	PhIP	MESH:D005947	55023	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|formation formation|nmod|END_ENTITY	Effects of glucose on the formation of PhIP in a model system .
16272157	0	glucose	55,62	Phosphatidylinositol_3-kinase	0,29	glucose	Phosphatidylinositol 3-kinase	MESH:D005947	18708(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY critical|nmod|metabolism critical|nsubj|activity activity|amod|END_ENTITY	Phosphatidylinositol_3-kinase activity is critical for glucose metabolism and embryo survival in murine blastocysts .
21858384	0	glucose	48,55	Pigment_epithelium-derived_factor	0,33	glucose	Pigment epithelium-derived factor	MESH:D005947	57104	Chemical	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Pigment_epithelium-derived_factor inhibits high glucose induced oxidative stress and fibrosis of cultured human glomerular mesangial cells .
3331233	0	glucose	47,54	Plasma_insulin_and_C-peptide	0,28	glucose	Plasma insulin and C-peptide	MESH:D005947	3630	Chemical	Gene	load|compound|START_ENTITY responses|nmod|load responses|amod|END_ENTITY	Plasma_insulin_and_C-peptide responses to oral glucose load after physical exercise in men with normal and impaired_glucose_tolerance .
7519664	0	glucose	109,116	Plasminogen_activator_inhibitor-1	0,33	glucose	Plasminogen activator inhibitor-1	MESH:D005947	281375(Tax:9913)	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|expression expression|amod|END_ENTITY	Plasminogen_activator_inhibitor-1 expression by brain microvessel endothelial cells is inhibited by elevated glucose .
24040030	0	glucose	24,31	Plin2	0,5	glucose	Plin2	MESH:D005947	11520(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY inhibits|dobj|uptake inhibits|nsubj|END_ENTITY	Plin2 inhibits cellular glucose uptake through interactions with SNAP23 , a SNARE complex protein .
17558484	0	glucose	31,38	Proinsulin	0,10	glucose	Proinsulin	MESH:D005947	3630	Chemical	Gene	ratios|compound|START_ENTITY END_ENTITY|dep|ratios	Proinsulin : insulin and insulin : glucose ratios as predictors of carotid plaque growth : a population-based 7 year follow-up of the Troms Study .
3042255	0	glucose	68,75	Proinsulin	0,10	glucose	Proinsulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY cystic_fibrosis|nmod|tolerance END_ENTITY|nmod|cystic_fibrosis	Proinsulin , insulin , and C-peptide in cystic_fibrosis after an oral glucose tolerance test .
8446045	0	glucose	60,67	Proinsulin	0,10	glucose	Proinsulin	MESH:D005947	3630	Chemical	Gene	challenges|compound|START_ENTITY concentrations|nmod|challenges concentrations|compound|END_ENTITY	Proinsulin and insulin concentrations following intravenous glucose challenges in normal , obese , and non-insulin-dependent diabetic subjects .
9015667	0	glucose	43,50	Proinsulin	0,10	glucose	Proinsulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY levels|nmod|tolerance levels|compound|END_ENTITY	Proinsulin and insulin levels according to glucose tolerance among Japanese-Brazilians , aged 40-79 years .
16752178	0	glucose	119,126	Prolactin	0,9	glucose	Prolactin	MESH:D005947	24683(Tax:10116)	Chemical	Gene	stimulation|compound|START_ENTITY response|nmod|stimulation gene|nmod|response factor|nmod|gene protein|nmod|factor END_ENTITY|dobj|protein	Prolactin regulatory element binding protein as a potential transcriptional factor for the insulin gene in response to glucose stimulation .
3308438	0	glucose	35,42	Prolactin	0,9	glucose	Prolactin	MESH:D005947	24683(Tax:10116)	Chemical	Gene	threshold|compound|START_ENTITY decreases|dobj|threshold decreases|nsubj|END_ENTITY	Prolactin -LRB- in vitro -RRB- decreases the glucose stimulation threshold , enhances insulin secretion , and increases dye coupling among islet B cells .
8344197	0	glucose	32,39	Prolactin	0,9	glucose	Prolactin	MESH:D005947	24683(Tax:10116)	Chemical	Gene	maturation|nmod|START_ENTITY induces|dobj|maturation induces|nsubj|END_ENTITY	Prolactin induces maturation of glucose sensing mechanisms in cultured neonatal rat islets .
19036882	0	glucose	42,49	Prolactin_receptor	0,18	glucose	Prolactin receptor	MESH:D005947	19116(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY required|nmod|homeostasis required|nsubjpass|END_ENTITY	Prolactin_receptor is required for normal glucose homeostasis and modulation of beta-cell mass during pregnancy .
22532369	0	glucose	55,62	Protein_arginine_methyltransferase_1	0,36	glucose	Protein arginine methyltransferase 1	MESH:D005947	180326(Tax:6239)	Chemical	Gene	production|compound|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	Protein_arginine_methyltransferase_1 regulates hepatic glucose production in a FoxO1-dependent manner .
1511501	0	glucose	47,54	Protein_kinase_C	0,16	glucose	Protein kinase C	MESH:D005947	24681(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Protein_kinase_C activity and lipogenesis from glucose in isolated adipocytes of endotoxemic rats .
16338977	0	glucose	72,79	Protein_kinase_C	0,16	glucose	Protein kinase C	MESH:D005947	112476	Chemical	Gene	depletion|compound|START_ENTITY death|nmod|depletion erythrocyte|dobj|death erythrocyte|nsubj|mediates mediates|amod|END_ENTITY	Protein_kinase_C mediates erythrocyte `` programmed cell death '' following glucose depletion .
19826193	0	glucose	31,38	Protein_kinase_C	0,16	glucose	Protein kinase C	MESH:D005947	24681(Tax:10116)	Chemical	Gene	effect|compound|START_ENTITY mediated|dobj|effect mediated|nsubj|END_ENTITY	Protein_kinase_C mediated high glucose effect on adenosine receptors expression in rat B lymphocytes .
21709315	0	glucose	29,36	Pyruvate_kinase_M2	0,18	glucose	Pyruvate kinase M2	MESH:D005947	5315	Chemical	Gene	metabolism|compound|START_ENTITY regulates|dobj|metabolism regulates|nsubj|END_ENTITY	Pyruvate_kinase_M2 regulates glucose metabolism by functioning as a coactivator for hypoxia-inducible_factor_1 in cancer cells .
1603079	2	glucose	91,98	RAG1	116,120	glucose	RAG1	MESH:D005947	856492(Tax:4932)	Chemical	Gene	gene|compound|START_ENTITY regulation|nmod|gene END_ENTITY|nsubj|regulation	Transcriptional regulation of the glucose transporter gene RAG1 .
22355071	0	glucose	14,21	ROCK1	35,40	glucose	ROCK1	MESH:D005947	6093	Chemical	Gene	transport|compound|START_ENTITY transport|nmod|END_ENTITY	Regulation of glucose transport by ROCK1 differs from that of ROCK2 and is controlled by actin polymerization .
16164644	0	glucose	61,68	Renal-specific_oxidoreductase	0,29	glucose	Renal-specific oxidoreductase	MESH:D005947	56727(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Renal-specific_oxidoreductase biphasic expression under high glucose ambience during fetal versus neonatal development .
12618360	0	glucose	18,25	Resistin	0,8	glucose	Resistin	MESH:D005947	246250(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY inhibits|dobj|uptake inhibits|nsubj|END_ENTITY	Resistin inhibits glucose uptake in L6 cells independently of changes in insulin signaling and GLUT4 translocation .
26909974	0	glucose	57,64	Resistin	0,8	glucose	Resistin	MESH:D005947	246250(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY expression|nmod|metabolism expression|compound|END_ENTITY	Resistin expression in adipose tissues and its effect on glucose metabolism in rats with brain_injury .
25356107	0	glucose	75,82	Response_gene_to_complement_32	0,30	glucose	Response gene to complement 32	MESH:D005947	66214(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|END_ENTITY	Response_gene_to_complement_32 -LRB- RGC-32 -RRB- in endothelial cells is induced by glucose and helpful to maintain glucose homeostasis .
24573864	0	glucose	59,66	Retn	35,39	glucose	Retn	MESH:D005947	57264(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Influence and related mechanism of Retn gene expression on glucose uptake in 3T3-L1 cells .
12861007	0	glucose	55,62	Rgt1	90,94	glucose	Rgt1	MESH:D005947	853828(Tax:4932)	Chemical	Gene	gene|compound|START_ENTITY binding|nmod|gene END_ENTITY|amod|binding	Specificity and regulation of DNA binding by the yeast glucose transporter gene repressor Rgt1 .
12925759	6	glucose	885,892	Rgt1	817,821	glucose	Mth1	MESH:D005947	851870(Tax:4932)	Chemical	Gene	absence|nmod|START_ENTITY leads|nmod|absence leads|nmod|hyperphosphorylation hyperphosphorylation|nmod|END_ENTITY	We show that inactivation of Mth1 and Std1 , known negative regulators of HXT gene expression , leads to the hyperphosphorylation of Rgt1 and its dissociation from HXT promoters even in the absence of glucose .
14508605	0	glucose	54,61	Rgt1	31,35	glucose	Rgt1	MESH:D005947	853828(Tax:4932)	Chemical	Gene	absence|nmod|START_ENTITY END_ENTITY|nmod|absence	Repression of transcription by Rgt1 in the absence of glucose requires Std1 and Mth1 .
15489524	0	glucose	78,85	Rgt1	8,12	glucose	Rgt1	MESH:D005947	853828(Tax:4932)	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|factor factor|amod|END_ENTITY	How the Rgt1 transcription factor of Saccharomyces_cerevisiae is regulated by glucose .
16844691	0	glucose	72,79	Rgt1	41,45	glucose	Rgt1	MESH:D005947	853828(Tax:4932)	Chemical	Gene	genes|compound|START_ENTITY expression|nmod|genes regulate|dobj|expression converge|xcomp|regulate converge|nmod|END_ENTITY	Two glucose-sensing pathways converge on Rgt1 to regulate expression of glucose transporter genes in Saccharomyces_cerevisiae .
21748783	0	glucose	29,36	Rgt1	121,125	glucose	Rgt1	MESH:D005947	853828(Tax:4932)	Chemical	Gene	dissection|nmod|START_ENTITY repressor|nsubj|dissection repressor|dobj|END_ENTITY	Functional dissection of the glucose signaling pathways that regulate the yeast glucose transporter gene -LRB- HXT -RRB- repressor Rgt1 .
21748783	0	glucose	80,87	Rgt1	121,125	glucose	Rgt1	MESH:D005947	853828(Tax:4932)	Chemical	Gene	gene|compound|START_ENTITY regulate|dobj|gene pathways|acl:relcl|regulate signaling|dobj|pathways glucose|acl|signaling dissection|nmod|glucose repressor|nsubj|dissection repressor|dobj|END_ENTITY	Functional dissection of the glucose signaling pathways that regulate the yeast glucose transporter gene -LRB- HXT -RRB- repressor Rgt1 .
25446262	0	glucose	5,12	RhoA	52,56	glucose	RhoA	MESH:D005947	387	Chemical	Gene	activates|nsubj|START_ENTITY activates|nmod|END_ENTITY	High glucose activates Raw264 .7 macrophages through RhoA kinase-mediated signaling pathway .
24275002	0	glucose	39,46	S100B	18,23	glucose	S100B	MESH:D005947	6285	Chemical	Gene	test|compound|START_ENTITY END_ENTITY|nmod|test	Decrease of serum S100B during an oral glucose tolerance test correlates inversely with the insulin response .
10221766	0	glucose	45,52	S14	67,70	glucose	S14	MESH:D005947	6208	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|transcription transcription|compound|END_ENTITY	Two different gene elements are required for glucose regulation of S14 transcription .
21200089	0	glucose	25,32	SARA	1,5	glucose	SARA	MESH:D005947	9372	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	-LSB- SARA expression in high glucose induced epithelium to mesenchymal transition of proximal tubule cells -RSB- .
27065222	0	glucose	11,18	SCAP	0,4	glucose	SCAP	MESH:D005947	22937	Chemical	Gene	links|dobj|START_ENTITY links|nsubj|END_ENTITY	SCAP links glucose to lipid metabolism in cancer cells .
19000377	0	glucose	19,26	SERT	30,34	glucose	SERT	MESH:D005947	6532	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of high glucose on SERT , the human plasmalemmal serotonin_transporter .
21980074	0	glucose	23,30	SGK3	15,19	glucose	SGK3	MESH:D005947	170755(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY END_ENTITY|nmod|homeostasis	Novel role for SGK3 in glucose homeostasis revealed in SGK3/Akt2 double-null mice .
10480331	0	glucose	112,119	SGLT1	135,140	glucose	SGLT1	MESH:D005947	25552(Tax:10116)	Chemical	Gene	cotransporter|compound|START_ENTITY cotransporter|appos|END_ENTITY	Transport and recognition of aminopeptidase-resistant cellobiose-coupled tyrosylglycylglycine by intestinal Na + / glucose cotransporter -LRB- SGLT1 -RRB- : recognition of sugar conjugates by SGLT1 is much less restricted than transport .
10480331	0	glucose	112,119	SGLT1	178,183	glucose	SGLT1	MESH:D005947	25552(Tax:10116)	Chemical	Gene	cotransporter|compound|START_ENTITY intestinal|dep|cotransporter intestinal|nmod|END_ENTITY	Transport and recognition of aminopeptidase-resistant cellobiose-coupled tyrosylglycylglycine by intestinal Na + / glucose cotransporter -LRB- SGLT1 -RRB- : recognition of sugar conjugates by SGLT1 is much less restricted than transport .
10526170	0	glucose	70,77	SGLT1	93,98	glucose	SGLT1	MESH:D005947	6523	Chemical	Gene	cotransporter|compound|START_ENTITY cotransporter|appos|END_ENTITY	Purification and functional reconstitution of a truncated human Na -LRB- + -RRB- / glucose cotransporter -LRB- SGLT1 -RRB- expressed in E. _ coli .
10926676	0	glucose	55,62	SGLT1	93,98	glucose	SGLT1	MESH:D005947	6523	Chemical	Gene	cotransporters|compound|START_ENTITY cotransporters|dep|comparison comparison|nmod|END_ENTITY	Glycoside binding and translocation in Na -LRB- + -RRB- - dependent glucose cotransporters : comparison of SGLT1 and SGLT3 .
11205056	0	glucose	22,29	SGLT1	46,51	glucose	SGLT1	MESH:D005947	282361(Tax:9913)	Chemical	Gene	co-transporter|compound|START_ENTITY Expression|nmod|co-transporter Expression|appos|END_ENTITY	Expression of the Na + / glucose co-transporter -LRB- SGLT1 -RRB- in the intestine of domestic and wild ruminants .
11606209	0	glucose	55,62	SGLT1	77,82	glucose	SGLT1	MESH:D005947	492300(Tax:9940)	Chemical	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Transcriptional regulation of the ovine intestinal Na + / glucose cotransporter SGLT1 gene .
11741601	0	glucose	99,106	SGLT1	122,127	glucose	SGLT1	MESH:D005947	6523	Chemical	Gene	cotransporter|dep|START_ENTITY cotransporter|dep|mRNA mRNA|appos|END_ENTITY	HuR binds a cyclic nucleotide-dependent , stabilizing domain in the 3 ' untranslated region of Na -LRB- + -RRB- / glucose cotransporter -LRB- SGLT1 -RRB- mRNA .
11831390	0	glucose	33,40	SGLT1	27,32	glucose	SGLT1	MESH:D005947	25552(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	The apical localization of SGLT1 glucose transporter is determined by the short amino_acid sequence in its N-terminal domain .
12927799	0	glucose	34,41	SGLT1	92,97	glucose	SGLT1	MESH:D005947	20537(Tax:10090)	Chemical	Gene	reabsorption|compound|START_ENTITY reduce|dobj|reabsorption reduce|nmod|down-regulation down-regulation|nmod|END_ENTITY	Aminoglycoside antibiotics reduce glucose reabsorption in kidney through down-regulation of SGLT1 .
1449065	0	glucose	8,15	SGLT1	31,36	glucose	SGLT1	MESH:D005947	6523	Chemical	Gene	cotransporter|compound|START_ENTITY cotransporter|appos|END_ENTITY	The Na + / glucose cotransporter -LRB- SGLT1 -RRB- .
14659592	0	glucose	55,62	SGLT1	129,134	glucose	SGLT1	MESH:D005947	25552(Tax:10116)	Chemical	Gene	uptake|nmod|START_ENTITY decline|nmod|uptake accompanied|nsubjpass|decline accompanied|nmod|changes changes|nmod|abundance abundance|nmod|END_ENTITY	The age-associated decline in the intestinal uptake of glucose is not accompanied by changes in the mRNA or protein abundance of SGLT1 .
18006167	0	glucose	104,111	SGLT1	127,132	glucose	SGLT1	MESH:D005947	25552(Tax:10116)	Chemical	Gene	cotransporter|compound|START_ENTITY cotransporter|appos|END_ENTITY	Polymer-phloridzin conjugates as an anti-diabetic drug that inhibits glucose absorption through the Na + / glucose cotransporter -LRB- SGLT1 -RRB- in the small intestine .
18006167	0	glucose	69,76	SGLT1	127,132	glucose	SGLT1	MESH:D005947	25552(Tax:10116)	Chemical	Gene	absorption|compound|START_ENTITY inhibits|dobj|absorption inhibits|nmod|cotransporter cotransporter|appos|END_ENTITY	Polymer-phloridzin conjugates as an anti-diabetic drug that inhibits glucose absorption through the Na + / glucose cotransporter -LRB- SGLT1 -RRB- in the small intestine .
18549898	0	glucose	23,30	SGLT1	129,134	glucose	SGLT1	MESH:D005947	6523	Chemical	Gene	uptake|compound|START_ENTITY rhythmicity|nmod|uptake mediated|nsubjpass|rhythmicity mediated|nmod|periodicity periodicity|nmod|expression expression|nmod|sodium-glucose_cotransporter sodium-glucose_cotransporter|appos|END_ENTITY	Diurnal rhythmicity in glucose uptake is mediated by temporal periodicity in the expression of the sodium-glucose_cotransporter -LRB- SGLT1 -RRB- .
19122974	0	glucose	72,79	SGLT1	94,99	glucose	SGLT1	MESH:D005947	20537(Tax:10090)	Chemical	Gene	cotransporter|compound|START_ENTITY cotransporter|dep|END_ENTITY	Involvement of amino_acid 36 in TM1 in voltage sensitivity in mouse Na + / glucose cotransporter SGLT1 .
19509029	0	glucose	25,32	SGLT1	0,5	glucose	SGLT1	MESH:D005947	6523	Chemical	Gene	transporter|compound|START_ENTITY transporter|nsubj|END_ENTITY	SGLT1 is a novel cardiac glucose transporter that is perturbed in disease states .
19808907	10	glucose	1774,1781	SGLT1	1743,1748	glucose	SGLT1	MESH:D005947	20537(Tax:10090)	Chemical	Gene	sensor|compound|START_ENTITY serves|nmod|sensor serves|nsubj|END_ENTITY	Our findings indicate that SGLT1 serves as the intestinal glucose sensor for glucose-induced incretin secretion and that a noncalorigenic SGLT1 substrate ameliorates hyperglycemia by stimulating incretin secretion .
20600102	0	glucose	23,30	SGLT1	0,5	glucose	SGLT1	MESH:D005947	72045(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|appos|transporter	SGLT1 , a novel cardiac glucose transporter , mediates increased glucose uptake in PRKAG2 cardiomyopathy .
20600102	0	glucose	63,70	SGLT1	0,5	glucose	SGLT1	MESH:D005947	72045(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY mediates|dobj|uptake mediates|nsubj|END_ENTITY	SGLT1 , a novel cardiac glucose transporter , mediates increased glucose uptake in PRKAG2 cardiomyopathy .
21190656	0	glucose	27,34	SGLT1	50,55	glucose	SGLT1	MESH:D005947	6523	Chemical	Gene	cotransporter|nsubj|START_ENTITY cotransporter|xcomp|rate rate|dep|END_ENTITY	Determination of the Na -LRB- + -RRB- / glucose cotransporter -LRB- SGLT1 -RRB- turnover rate using the ion-trap technique .
21433280	0	glucose	130,137	SGLT1	95,100	glucose	SGLT1	MESH:D005947	25552(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY rat|nmod|effects rat|dobj|levels levels|compound|END_ENTITY	Rosmarinic_acid , major phenolic constituent of Greek sage herbal tea , modulates rat intestinal SGLT1 levels with effects on blood glucose .
22796500	0	glucose	43,50	SGLT1	75,80	glucose	SGLT1	MESH:D005947	6523	Chemical	Gene	Development|nmod|START_ENTITY uptake|nsubj|Development uptake|dobj|system system|nmod|END_ENTITY	Development of a cell-based nonradioactive glucose uptake assay system for SGLT1 and SGLT2 .
23361943	0	glucose	15,22	SGLT1	118,123	glucose	SGLT1	MESH:D005947	6523	Chemical	Gene	transport|compound|START_ENTITY Attenuation|nmod|transport Attenuation|dep|interactions interactions|nmod|transporters transporters|compound|END_ENTITY	Attenuation of glucose transport across Caco-2 cell monolayers by a polyphenol-rich herbal extract : interactions with SGLT1 and GLUT2 transporters .
23487174	0	glucose	154,161	SGLT1	113,118	glucose	SGLT1	MESH:D005947	20537(Tax:10090)	Chemical	Gene	absorption|nmod|START_ENTITY cotransporter_1|dep|absorption cotransporter_1|appos|END_ENTITY	LX4211 increases serum glucagon-like_peptide_1 and peptide_YY levels by reducing sodium/glucose _ cotransporter_1 -LRB- SGLT1 -RRB- - mediated absorption of intestinal glucose .
23487174	5	glucose	1474,1481	SGLT1	1536,1541	glucose	SGLT1	MESH:D005947	20537(Tax:10090)	Chemical	Gene	minutes|nmod|START_ENTITY mice|appos|minutes consistent|nsubj|mice /|parataxis|consistent decreased|csubj|/ decreased|dobj|activity activity|compound|END_ENTITY	However , GLP-1 and GIP levels were not increased in LX4211-treated mice and were decreased in SGLT1 - / - mice , 5 minutes after oral glucose , consistent with studies linking decreased intestinal SGLT1 activity with reduced GLP-1 and GIP levels 5 minutes after oral glucose .
23487174	5	glucose	1606,1613	SGLT1	1536,1541	glucose	SGLT1	MESH:D005947	20537(Tax:10090)	Chemical	Gene	decreased|nmod|START_ENTITY decreased|dobj|activity activity|compound|END_ENTITY	However , GLP-1 and GIP levels were not increased in LX4211-treated mice and were decreased in SGLT1 - / - mice , 5 minutes after oral glucose , consistent with studies linking decreased intestinal SGLT1 activity with reduced GLP-1 and GIP levels 5 minutes after oral glucose .
24587162	0	glucose	42,49	SGLT1	12,17	glucose	SGLT1	MESH:D005947	20537(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of SGLT1 and GLUT2 in intestinal glucose transport and sensing .
24962566	0	glucose	23,30	SGLT1	86,91	glucose	SGLT1	MESH:D005947	6523	Chemical	Gene	START_ENTITY|amod|binding binding|nmod|END_ENTITY	Forces and dynamics of glucose and inhibitor binding to sodium_glucose_co-transporter SGLT1 studied by single molecule force spectroscopy .
25074384	0	glucose	140,147	SGLT1	67,72	glucose	SGLT1	MESH:D005947	20537(Tax:10090)	Chemical	Gene	levels|compound|START_ENTITY reduces|dobj|levels reduces|nsubj|Inhibition Inhibition|nmod|sodium-coupled_glucose_transporter_1 sodium-coupled_glucose_transporter_1|appos|END_ENTITY	Inhibition of the intestinal sodium-coupled_glucose_transporter_1 -LRB- SGLT1 -RRB- by extracts and polyphenols from apple reduces postprandial blood glucose levels in mice and humans .
25540623	0	glucose	108,115	SGLT1	83,88	glucose	SGLT1	MESH:D005947	6523	Chemical	Gene	reabsorption|compound|START_ENTITY characteristics|nmod|reabsorption characteristics|nmod|END_ENTITY	Use of systems pharmacology modeling to elucidate the operating characteristics of SGLT1 and SGLT2 in renal glucose reabsorption in humans .
25711084	0	glucose	40,47	SGLT1	25,30	glucose	SGLT1	MESH:D005947	6523	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	-LSB- The interaction between SGLT1 or GLUT2 glucose transporter and the cytoskeleton in the enterocyte as well as Caco2 cell during hexose absorption -RSB- .
26038705	0	glucose	28,35	SGLT1	79,84	glucose	SGLT1	MESH:D005947	20537(Tax:10090)	Chemical	Gene	excretion|compound|START_ENTITY maximizes|dobj|excretion maximizes|advcl|inhibiting inhibiting|dobj|END_ENTITY	LP-925219 maximizes urinary glucose excretion in mice by inhibiting both renal SGLT1 and SGLT2 .
26140358	9	glucose	1130,1137	SGLT1	1185,1190	glucose	PEPT1	MESH:D005947	6564	Chemical	Gene	absorption|compound|START_ENTITY mediated|nsubjpass|absorption mediated|nmod|Na Na|dep|protein protein|compound|END_ENTITY	While glucose absorption is mediated by the Na -LRB- + -RRB- - dependent SGLT1 protein , uptake of short-chain peptides is mediated by the H -LRB- + -RRB- - coupled PEPT1 protein .
26791832	0	glucose	57,64	SGLT1	0,5	glucose	SGLT1	MESH:D005947	20537(Tax:10090)	Chemical	Gene	appetition|compound|START_ENTITY required|nmod|appetition required|nsubjpass|transporter/sensor transporter/sensor|nummod|END_ENTITY	SGLT1 sugar transporter/sensor is required for post-oral glucose appetition .
26902517	0	glucose	87,94	SGLT1	0,5	glucose	SGLT1	MESH:D005947	25552(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY surface|dobj|concentration surface|nsubj|activity activity|nummod|END_ENTITY	SGLT1 activity in lung alveolar cells of diabetic rats modulates airway surface liquid glucose concentration and bacterial proliferation .
2714793	0	glucose	39,46	SGLT1	67,72	glucose	SGLT1	MESH:D005947	6523	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Assignment of the human intestinal Na + / glucose cotransporter gene -LRB- SGLT1 -RRB- to the q11 .2 -- qter region of chromosome 22 .
7510295	0	glucose	18,25	SGLT1	41,46	glucose	SGLT1	MESH:D005947	397113(Tax:9823)	Chemical	Gene	cotransporter|compound|START_ENTITY cotransporter|appos|END_ENTITY	Regulation of Na + / glucose cotransporter -LRB- SGLT1 -RRB- mRNA in LLC-PK1 cells .
8224142	0	glucose	29,36	SGLT1	52,57	glucose	SGLT1	MESH:D005947	6523	Chemical	Gene	cotransporter|compound|START_ENTITY Targeting|nmod|cotransporter Targeting|appos|END_ENTITY	Targeting of recombinant Na + / glucose cotransporter -LRB- SGLT1 -RRB- to the apical membrane .
8244393	0	glucose	28,35	SGLT1	55,60	glucose	SGLT1	MESH:D005947	6523	Chemical	Gene	gene|compound|START_ENTITY Assignment|nmod|gene END_ENTITY|nsubj|Assignment	Assignment of the human Na + / glucose cotransporter gene SGLT1 to chromosome 22q13 .1 .
8452856	0	glucose	26,33	SGLT1	49,54	glucose	SGLT1	MESH:D005947	492300(Tax:9940)	Chemical	Gene	cotransporter|compound|START_ENTITY cotransporter|appos|END_ENTITY	The expression of the Na + / glucose cotransporter -LRB- SGLT1 -RRB- gene in lamb small intestine during postnatal development .
8484724	0	glucose	39,46	SGLT1	63,68	glucose	SGLT1	MESH:D005947	492300(Tax:9940)	Chemical	Gene	co-transporter|compound|START_ENTITY co-transporter|appos|END_ENTITY	Regulation of the ovine intestinal Na + / glucose co-transporter -LRB- SGLT1 -RRB- is dissociated from mRNA abundance .
8563765	0	glucose	15,22	SGLT1	38,43	glucose	SGLT1	MESH:D005947	6523	Chemical	Gene	cotransporter|compound|START_ENTITY cotransporter|appos|END_ENTITY	Defects in Na + / glucose cotransporter -LRB- SGLT1 -RRB- trafficking and function cause glucose-galactose_malabsorption .
8599647	0	glucose	40,47	SGLT1	77,82	glucose	SGLT1	MESH:D005947	6523	Chemical	Gene	ratio|compound|START_ENTITY ratio|nmod|cotransporter cotransporter|compound|END_ENTITY	Thermodynamic determination of the Na + : glucose coupling ratio for the human SGLT1 cotransporter .
8955098	0	glucose	50,57	SGLT1	108,113	glucose	SGLT1	MESH:D005947	397113(Tax:9823)	Chemical	Gene	SGLT2|compound|START_ENTITY reveal|nsubj|SGLT2 reveal|dobj|mechanism mechanism|nmod|END_ENTITY	Biophysical characteristics of the pig kidney Na + / glucose cotransporter SGLT2 reveal a common mechanism for SGLT1 and SGLT2 .
8985740	0	glucose	16,23	SGLT1	36,41	glucose	SGLT1	MESH:D005947	492299(Tax:9615)	Chemical	Gene	transporter|compound|START_ENTITY transporter|acl:relcl|localized localized|nsubj|END_ENTITY	Na -LRB- + -RRB- - dependent glucose transporter SGLT1 is localized in the apical plasma membrane upon completion of tight junction formation in MDCK cells .
9015374	0	glucose	42,49	SGLT1	66,71	glucose	SGLT1	MESH:D005947	6523	Chemical	Gene	START_ENTITY|dep|expression expression|compound|gene gene|appos|END_ENTITY	Nutrient regulation of the intestinal Na + / glucose co-transporter -LRB- SGLT1 -RRB- gene expression .
22351116	0	glucose	24,31	SGLT2	44,49	glucose	SGLT2	MESH:D005947	100286743(Tax:9823)	Chemical	Gene	transporter|compound|START_ENTITY modulation|nmod|transporter END_ENTITY|nsubj|modulation	Autocrine modulation of glucose transporter SGLT2 by IL-6 and TNF-a in LLC-PK -LRB- 1 -RRB- cells .
24150605	0	glucose	27,34	SH2B1	0,5	glucose	SH2B1	MESH:D005947	25970	Chemical	Gene	metabolism|compound|START_ENTITY regulates|dobj|metabolism regulates|nsubj|END_ENTITY	SH2B1 in b-cells regulates glucose metabolism by promoting b-cell survival and islet expansion .
20217115	0	glucose	137,144	SIRT1	0,5	glucose	SIRT1	MESH:D005947	23411	Chemical	Gene	ingestion|compound|START_ENTITY influence|nmod|ingestion phosphorylation|dep|influence phosphorylation|amod|END_ENTITY	SIRT1 , AMP-activated_protein_kinase phosphorylation and downstream kinases in response to a single bout of sprint exercise : influence of glucose ingestion .
18577546	0	glucose	96,103	SLC2A1	75,81	glucose	SLC2A1	MESH:D005947	6513	Chemical	Gene	GLUT1|compound|START_ENTITY encoding|dobj|GLUT1 mutations|acl|encoding mutations|nmod|END_ENTITY	Paroxysmal exercise-induced dyskinesia and epilepsy is due to mutations in SLC2A1 , encoding the glucose transporter GLUT1 .
20540786	0	glucose	82,89	SLC2A1	108,114	glucose	SLC2A1	MESH:D005947	6513	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The association of 18F-deoxyglucose -LRB- FDG -RRB- uptake of PET with polymorphisms in the glucose transporter gene -LRB- SLC2A1 -RRB- and hypoxia-related genes -LRB- HIF1A , VEGFA , APEX1 -RRB- in non-small_cell_lung_cancer .
22899793	0	glucose	16,23	SLC2A1	8,14	glucose	SLC2A1	MESH:D005947	6513	Chemical	Gene	Lack|dep|START_ENTITY Lack|nmod|END_ENTITY	Lack of SLC2A1 -LRB- glucose transporter 1 -RRB- mutations in 30 Italian patients with alternating hemiplegia of childhood .
8521728	0	glucose	18,25	SLC2A1	46,52	glucose	SLC2A1	MESH:D005947	397404(Tax:9823)	Chemical	Gene	Assignment|nmod|START_ENTITY gene|dep|Assignment gene|appos|END_ENTITY	Assignment of the glucose transporter 1 gene -LRB- SLC2A1 -RRB- to swine chromosome 6q34 -- > qter .
12941788	0	glucose	32,39	SLC2A10	53,60	glucose	SLC2A10	MESH:D005947	81031	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Genetic variation of the GLUT10 glucose transporter -LRB- SLC2A10 -RRB- and relationships to type 2 diabetes and intermediary traits .
16336637	0	glucose	31,38	SLC2A10	52,59	glucose	SLC2A10	MESH:D005947	81031	Chemical	Gene	transporter|compound|START_ENTITY analysis|nmod|transporter analysis|appos|END_ENTITY	Genetic analysis of the GLUT10 glucose transporter -LRB- SLC2A10 -RRB- polymorphisms in Caucasian American type 2 diabetes .
24452335	0	glucose	38,45	SLC2A3	63,69	glucose	SLC2A3	MESH:D005947	6515	Chemical	Gene	variation|nmod|START_ENTITY transporter|nsubj|variation transporter|dobj|END_ENTITY	Copy-number variation of the neuronal glucose transporter gene SLC2A3 and age_of_onset in Huntington 's _ disease .
19492079	0	glucose	20,27	SLC30A3	0,7	glucose	SLC30A3	MESH:D005947	22784(Tax:10090)	Chemical	Gene	responds|nmod|START_ENTITY responds|nsubj|END_ENTITY	SLC30A3 responds to glucose - and zinc variations in beta-cells and is critical for insulin production and in vivo glucose-metabolism during beta-cell stress .
2406560	0	glucose	32,39	SNF3	27,31	glucose	SNF3	MESH:D005947	851333(Tax:4932)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Mutational analysis of the SNF3 glucose transporter of Saccharomyces_cerevisiae .
3281163	0	glucose	30,37	SNF3	10,14	glucose	SNF3	MESH:D005947	851333(Tax:4932)	Chemical	Gene	transporter|compound|START_ENTITY encodes|dobj|transporter encodes|nsubj|gene gene|compound|END_ENTITY	The yeast SNF3 gene encodes a glucose transporter homologous to the mammalian protein .
9046082	0	glucose	147,154	SNF3	129,133	glucose	SNF3	MESH:D005947	851333(Tax:4932)	Chemical	Gene	recognition|compound|START_ENTITY functions|nmod|recognition functions|nummod|END_ENTITY	The C-terminal domain of Snf3p is sufficient to complement the growth defect of snf3 null mutations in Saccharomyces_cerevisiae : SNF3 functions in glucose recognition .
22031849	0	glucose	22,29	SREBP-1	0,7	glucose	SREBP-1	MESH:D005947	78968(Tax:10116)	Chemical	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	SREBP-1 activation by glucose mediates TGF-b upregulation in mesangial cells .
18178930	0	glucose	40,47	SREBP1	0,6	glucose	SREBP1	MESH:D005947	20787(Tax:10090)	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	SREBP1 is required for the induction by glucose of pancreatic beta-cell genes involved in glucose sensing .
16581004	0	glucose	57,64	STAT3	16,21	glucose	STAT3	MESH:D005947	20848(Tax:10090)	Chemical	Gene	production|compound|START_ENTITY Role|nmod|production Role|nmod|END_ENTITY	Role of hepatic STAT3 in brain-insulin action on hepatic glucose production .
3070646	0	glucose	19,26	Secretin	0,8	glucose	Secretin	MESH:D005947	20287(Tax:10090)	Chemical	Gene	inhibition|compound|START_ENTITY uncouples|dobj|inhibition uncouples|nsubj|END_ENTITY	Secretin uncouples glucose inhibition of glucagon-producing cells resulting in a simultaneous stimulation of both glucagon and insulin release .
11788466	0	glucose	120,127	Semicarbazide-sensitive_amine_oxidase	0,37	glucose	Semicarbazide-sensitive amine oxidase	MESH:D005947	29473(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY expression|nmod|uptake cells|dep|expression cells|amod|END_ENTITY	Semicarbazide-sensitive_amine_oxidase in vascular smooth muscle cells : differentiation-dependent expression and role in glucose uptake .
12686100	0	glucose	78,85	Semicarbazide-sensitive_amine_oxidase	0,37	glucose	Semicarbazide-sensitive amine oxidase	MESH:D005947	29473(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY effects|nmod|metabolism exerts|dobj|effects exerts|nsubj|activity activity|amod|END_ENTITY	Semicarbazide-sensitive_amine_oxidase activity exerts insulin-like effects on glucose metabolism and insulin-signaling pathways in adipose cells .
21781582	0	glucose	99,106	Sex_hormone-binding_globulin	1,29	glucose	Sex hormone-binding globulin	MESH:D005947	6462	Chemical	Gene	women|nmod|START_ENTITY END_ENTITY|nmod|women	-LSB- Sex_hormone-binding_globulin of gestational_diabetes_mellitus pregnant women with well-controlled glucose and pregnancy outcomes -RSB- .
26400961	0	glucose	53,60	Slc12a2	73,80	glucose	Slc12a2	MESH:D005947	20496(Tax:10090)	Chemical	Gene	disposal|compound|START_ENTITY disposal|nmod|END_ENTITY	Increased Slc12a1 expression in b-cells and improved glucose disposal in Slc12a2 heterozygous mice .
20014043	1	glucose	207,214	Snf3	115,119	glucose	Snf3	MESH:D005947	851333(Tax:4932)	Chemical	Gene	presence|nmod|START_ENTITY sense|dobj|presence able|xcomp|sense Saccharomyces_cerevisiae|amod|able protein|nmod|Saccharomyces_cerevisiae protein|nsubj|END_ENTITY	Snf3 is a plasma membrane protein in Saccharomyces_cerevisiae able to sense the presence of glucose .
20564191	0	glucose	35,42	Snf3	82,86	glucose	Snf3	MESH:D005947	851333(Tax:4932)	Chemical	Gene	Conditions|nmod|START_ENTITY inhibit|nsubj|Conditions inhibit|xcomp|sensing sensing|nmod|END_ENTITY	Conditions with high intracellular glucose inhibit sensing through glucose sensor Snf3 in Saccharomyces_cerevisiae .
2885337	0	glucose	45,52	Somatostatin	0,12	glucose	Somatostatin	MESH:D005947	6750	Chemical	Gene	disposal|compound|START_ENTITY alter|dobj|disposal alter|nsubj|END_ENTITY	Somatostatin does not alter insulin-mediated glucose disposal .
2901133	0	glucose	25,32	Somatostatin	0,12	glucose	Somatostatin	MESH:D005947	6750	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Somatostatin response to glucose before and after prolonged fasting in lean and obese non-diabetic subjects .
6129073	0	glucose	31,38	Somatostatin	0,12	glucose	Somatostatin	MESH:D005947	6750	Chemical	Gene	production|compound|START_ENTITY inhibits|dobj|production inhibits|nsubj|infusion infusion|compound|END_ENTITY	Somatostatin infusion inhibits glucose production in burn patients .
804491	0	glucose	118,125	Somatostatin	0,12	glucose	Somatostatin	MESH:D005947	24797(Tax:10116)	Chemical	Gene	homeostasis|compound|START_ENTITY blockade|nmod|homeostasis blockade|nmod|blockade blockade|compound|END_ENTITY	Somatostatin blockade of acute and chronic stimuli of the endocrine pancreas and the consequences of this blockade on glucose homeostasis .
2861129	0	glucose	39,46	Somatostatin-14	0,15	glucose	Somatostatin-14	MESH:D005947	6750	Chemical	Gene	levels|compound|START_ENTITY modulates|dobj|levels modulates|nsubj|END_ENTITY	Somatostatin-14 modulates postprandial glucose levels and release of gastrointestinal and pancreatic hormones .
18945941	0	glucose	5,12	Src	79,82	glucose	Src	MESH:D005947	20779(Tax:10090)	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|activation activation|nmod|END_ENTITY	High glucose promotes retinal endothelial cell migration through activation of Src , PI3K/Akt1/eNOS , and ERKs .
24584933	0	glucose	41,48	Steroid_receptor_coactivator-3	0,30	glucose	Steroid receptor coactivator-3	MESH:D005947	17979(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY regulates|dobj|metabolism regulates|nsubj|END_ENTITY	Steroid_receptor_coactivator-3 regulates glucose metabolism in bladder_cancer cells through coactivation of hypoxia inducible factor 1a .
22693207	0	glucose	67,74	TBC1D1	34,40	glucose	TBC1D1	MESH:D005947	57915(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY regulates|dobj|metabolism regulates|nsubj|END_ENTITY	The Rab-GTPase-activating protein TBC1D1 regulates skeletal muscle glucose metabolism .
25280670	0	glucose	63,70	TBC1D1	9,15	glucose	TBC1D1	MESH:D005947	23216	Chemical	Gene	transport|compound|START_ENTITY Roles|nmod|transport Roles|nmod|END_ENTITY	Roles of TBC1D1 and TBC1D4 in insulin - and exercise-stimulated glucose transport of skeletal muscle .
11309621	9	glucose	1253,1260	TC10	1212,1216	glucose	TC10	MESH:D005947	23433	Chemical	Gene	uptake|compound|START_ENTITY essential|nmod|uptake essential|nsubj|activation activation|nmod|END_ENTITY	The activation of TC10 is essential for insulin-stimulated glucose uptake and GLUT4 translocation .
17008399	0	glucose	45,52	TC10alpha	0,9	glucose	TC10alpha	MESH:D005947	23433	Chemical	Gene	uptake|compound|START_ENTITY required|nmod|uptake required|nsubjpass|END_ENTITY	TC10alpha is required for insulin-stimulated glucose uptake in adipocytes .
19473183	0	glucose	75,82	TCF7L2	21,27	glucose	TCF7L2	MESH:D005947	6934	Chemical	Gene	genotype|nmod|START_ENTITY genotype|nummod|END_ENTITY	Interactions between TCF7L2 genotype and growth_hormone-induced changes in glucose homeostasis in small for gestational age children .
23028378	0	glucose	17,24	TCF7L2	0,6	glucose	TCF7L2	MESH:D005947	21416(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY modulates|dobj|homeostasis modulates|nsubj|END_ENTITY	TCF7L2 modulates glucose homeostasis by regulating CREB - and FoxO1-dependent transcriptional pathway in the liver .
24317852	0	glucose	62,69	TCF7L2	0,6	glucose	TCF7L2	MESH:D005947	21416(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY role|nmod|homeostasis plays|dobj|role plays|nsubj|END_ENTITY	TCF7L2 in mouse pancreatic beta cells plays a crucial role in glucose homeostasis by regulating beta cell mass .
20878350	0	glucose	92,99	TGF-b1	38,44	glucose	TGF-b1	MESH:D005947	7040	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|role role|nmod|END_ENTITY	The role of thrombospondin-1-mediated TGF-b1 on collagen type III synthesis induced by high glucose .
10477140	0	glucose	5,12	TGF-beta	136,144	glucose	TGF-beta	MESH:D005947	7040	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|parataxis|mediation mediation|nmod|activation activation|nmod|END_ENTITY	High glucose stimulates proliferation and collagen type I synthesis in renal cortical fibroblasts : mediation by autocrine activation of TGF-beta .
11522874	0	glucose	11,18	TGF-beta	122,130	glucose	TGF-beta	MESH:D005947	7040	Chemical	Gene	dialysate|compound|START_ENTITY Effects|nmod|dialysate Effects|dep|role role|nmod|END_ENTITY	Effects of glucose dialysate on extracellular matrix production by human peritoneal mesothelial cells -LRB- HPMC -RRB- : the role of TGF-beta .
12753288	0	glucose	73,80	TGF-beta	8,16	glucose	TGF-beta	MESH:D005947	7040	Chemical	Gene	conditions|compound|START_ENTITY production|nmod|conditions signaling|nmod|production Role|acl|signaling Role|nmod|END_ENTITY	Role of TGF-beta signaling in extracellular matrix production under high glucose conditions .
1593845	0	glucose	9,16	TGF-beta	28,36	glucose	TGF-beta	MESH:D005947	21803(Tax:10090)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Elevated glucose stimulates TGF-beta gene expression and bioactivity in proximal tubule .
15284289	0	glucose	13,20	TGF-beta1	45,54	glucose	TGF-beta1	MESH:D005947	7040	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	High ambient glucose enhances sensitivity to TGF-beta1 via extracellular signal -- regulated kinase and protein_kinase_Cdelta activities in human mesangial cells .
18097729	0	glucose	29,36	TGF-beta1	0,9	glucose	TGF-beta1	MESH:D005947	100873157	Chemical	Gene	levels|nmod|START_ENTITY levels|amod|END_ENTITY	TGF-beta1 and high levels of glucose do not increase insulin cell proportions in the avian embryonic pancreas .
10231432	0	glucose	22,29	TGF-beta_1	0,10	glucose	TGF-beta 1	MESH:D005947	403998(Tax:9615)	Chemical	Gene	uptake|compound|START_ENTITY stimulates|dobj|uptake stimulates|nsubj|END_ENTITY	TGF-beta_1 stimulates glucose uptake by enhancing GLUT1 expression in mesangial cells .
12540377	0	glucose	5,12	TGF-beta_1	81,91	glucose	TGF-beta 1	MESH:D005947	7040	Chemical	Gene	START_ENTITY|dep|effects effects|amod|independent independent|nmod|END_ENTITY	High glucose and endothelial cell growth : novel effects independent of autocrine TGF-beta_1 and hyperosmolarity .
8534742	0	glucose	10,17	TGF-beta_1	21,31	glucose	TGF-beta 1	MESH:D005947	7040	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of glucose on TGF-beta_1 expression in peritoneal mesothelial cells .
8811326	0	glucose	9,16	TGF-beta_1	69,79	glucose	TGF-beta 1	MESH:D005947	7040	Chemical	Gene	levels|compound|START_ENTITY stimulate|nsubj|levels stimulate|dobj|transforming_growth_factor-beta_1 transforming_growth_factor-beta_1|appos|END_ENTITY	Elevated glucose levels stimulate transforming_growth_factor-beta_1 -LRB- TGF-beta_1 -RRB- , suppress interleukin IL-2 , IL-6 and IL-10 production and DNA synthesis in peripheral blood mononuclear cells .
10807596	0	glucose	49,56	TGF-beta_type_II_receptor	15,40	glucose	TGF-beta type II receptor	MESH:D005947	21813(Tax:10090)	Chemical	Gene	Stimulation|nmod|START_ENTITY Stimulation|nmod|END_ENTITY	Stimulation of TGF-beta_type_II_receptor by high glucose in mouse mesangial cells and in diabetic kidney .
22117840	0	glucose	96,103	TNF	38,41	glucose	TNF	MESH:D005947	7124	Chemical	Gene	tolerance|compound|START_ENTITY subjects|nmod|tolerance END_ENTITY|nmod|subjects	Smoking , white blood cell counts , and TNF system activity in Japanese male subjects with normal glucose tolerance .
22500980	0	glucose	5,12	TNF-a	35,40	glucose	TNF-a	MESH:D005947	7124	Chemical	Gene	concentrations|compound|START_ENTITY induce|nsubj|concentrations induce|dobj|production production|amod|END_ENTITY	High glucose concentrations induce TNF-a production through the down-regulation of CD33 in primary human monocytes .
24692847	0	glucose	39,46	TNF-a	30,35	glucose	TNF-a	MESH:D005947	7124	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	The acute effects of low-dose TNF-a on glucose metabolism and b-cell function in humans .
10329978	0	glucose	63,70	TNF-alpha	0,9	glucose	TNF-alpha	MESH:D005947	21926(Tax:10090)	Chemical	Gene	signaling|nmod|START_ENTITY signaling|amod|END_ENTITY	TNF-alpha impairs insulin signaling and insulin stimulation of glucose uptake in C2C12 muscle cells .
11944024	0	glucose	24,31	TNF-alpha	11,20	glucose	TNF-alpha	MESH:D005947	7124	Chemical	Gene	metabolism|compound|START_ENTITY Effects|nmod|metabolism Effects|nmod|END_ENTITY	Effects of TNF-alpha on glucose metabolism and lipolysis in adipose tissue and isolated fat-cell preparations .
12683923	0	glucose	98,105	TNF-alpha	10,19	glucose	TNF-alpha	MESH:D005947	21926(Tax:10090)	Chemical	Gene	concentrations|nmod|START_ENTITY exposed|nmod|concentrations exposed|nsubj|expression expression|amod|END_ENTITY	Increased TNF-alpha expression in cultured mouse embryos exposed to teratogenic concentrations of glucose .
1566928	0	glucose	15,22	TNF-alpha	56,65	glucose	TNF-alpha	MESH:D005947	24835(Tax:10116)	Chemical	Gene	metabolic|compound|START_ENTITY Attenuation|nmod|metabolic changes|nsubj|Attenuation changes|xcomp|resulting resulting|nmod|administration administration|amod|END_ENTITY	Attenuation of glucose metabolic changes resulting from TNF-alpha administration by adrenergic blockade .
17202326	0	glucose	133,140	TNF-alpha	37,46	glucose	TNF-alpha	MESH:D005947	21926(Tax:10090)	Chemical	Gene	dependent|nmod|START_ENTITY dependent|dep|Augmented Augmented|dobj|production production|amod|END_ENTITY	Augmented lipopolysaccharide-induced TNF-alpha production by peritoneal macrophages in type 2 diabetic mice is dependent on elevated glucose and requires p38_MAPK .
18436837	0	glucose	28,35	TNF-alpha	38,47	glucose	TNF-alpha	MESH:D005947	7124	Chemical	Gene	inhibits|dobj|START_ENTITY inhibits|dep|END_ENTITY	Dexamethasone inhibits high glucose - , TNF-alpha - , and IL-1beta-induced secretion of inflammatory and angiogenic mediators from retinal microvascular pericytes .
19038972	0	glucose	92,99	TNF-alpha	0,9	glucose	TNF-alpha	MESH:D005947	7124	Chemical	Gene	oxidation|compound|START_ENTITY leading|nmod|oxidation reduces|dep|leading reduces|nsubj|END_ENTITY	TNF-alpha reduces PGC-1alpha expression through NF-kappaB and p38 MAPK leading to increased glucose oxidation in a human cardiac cell model .
21047923	0	glucose	47,54	TNF-alpha	0,9	glucose	TNF-alpha	MESH:D005947	7124	Chemical	Gene	decreases|dobj|START_ENTITY decreases|nsubj|antagonism antagonism|amod|END_ENTITY	TNF-alpha antagonism with etanercept decreases glucose and increases the proportion of high molecular weight adiponectin in obese subjects with features of the metabolic_syndrome .
22397368	0	glucose	72,79	TNF-alpha	45,54	glucose	TNF-alpha	MESH:D005947	7124	Chemical	Gene	test|compound|START_ENTITY END_ENTITY|nmod|test	Postchallenge responses of nitrotyrosine and TNF-alpha during 75-g oral glucose tolerance test are associated with the presence of coronary_artery_diseases in patients with prediabetes .
8781295	9	glucose	1516,1523	TNF-alpha	1498,1507	glucose	TNF-alpha	MESH:D005947	24835(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY affects|dobj|metabolism affects|nsubj|END_ENTITY	These results suggest that TNF-alpha affects glucose metabolism , causing increased basal uptake in muscle cells and decreased uptake in adipocytes .
8803477	0	glucose	21,28	TNF-alpha	0,9	glucose	TNF-alpha	MESH:D005947	24835(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY stimulates|dobj|uptake stimulates|nsubj|END_ENTITY	TNF-alpha stimulates glucose uptake in L6 myoblasts .
21293471	0	glucose	5,12	TNFa	24,28	glucose	TNFa	MESH:D005947	24835(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	High glucose stimulates TNFa and MCP-1 expression in rat microglia via ROS and NF-kB pathways .
23866118	0	glucose	39,46	TNFa	0,4	glucose	TNFa	MESH:D005947	7124	Chemical	Gene	metabolism|compound|START_ENTITY stimulate|dobj|metabolism stimulate|nsubj|END_ENTITY	TNFa and IL-17 cooperatively stimulate glucose metabolism and growth factor production in human colorectal_cancer cells .
24512496	0	glucose	60,67	TNFa	43,47	glucose	TNFa	MESH:D005947	7124	Chemical	Gene	ingestion|compound|START_ENTITY induces|nmod|ingestion induces|dobj|response response|compound|END_ENTITY	Hyperandrogenism induces a proinflammatory TNFa response to glucose ingestion in a receptor-dependent fashion .
24517151	0	glucose	30,37	TNFa	0,4	glucose	TNFa	MESH:D005947	7124	Chemical	Gene	test|compound|START_ENTITY dynamics|nmod|test dynamics|compound|END_ENTITY	TNFa dynamics during the oral glucose tolerance test vary according to the level of insulin resistance in pregnant women .
16148943	0	glucose	57,64	TORC2	21,26	glucose	TORC2	MESH:D005947	200186	Chemical	Gene	metabolism|compound|START_ENTITY regulator|nmod|metabolism regulator|nsubj|END_ENTITY	The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism .
22315325	0	glucose	24,31	TRAF2	8,13	glucose	TRAF2	MESH:D005947	22030(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY regulates|dobj|metabolism regulates|nsubj|END_ENTITY	Hepatic TRAF2 regulates glucose metabolism through enhancing glucagon responses .
8589718	0	glucose	120,127	TRH	131,134	glucose	TRH	MESH:D005947	25569(Tax:10116)	Chemical	Gene	regulate|dobj|START_ENTITY regulate|nmod|END_ENTITY	Ectopic expression of thyrotropin_releasing_hormone -LRB- TRH -RRB- receptors in liver modulates organ function to regulate blood glucose by TRH .
17699555	0	glucose	51,58	TRPC6	18,23	glucose	TRPC6	MESH:D005947	89823(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Downregulation of TRPC6 protein expression by high glucose , a possible mechanism for the impaired Ca2 + signaling in glomerular mesangial cells in diabetes .
23294354	0	glucose	47,54	TRPC6	97,102	glucose	TRPC6	MESH:D005947	22068(Tax:10090)	Chemical	Gene	START_ENTITY|acl|induced induced|nmod|activation activation|nmod|END_ENTITY	Wnt/b-catenin signalling pathway mediates high glucose induced cell injury through activation of TRPC6 in podocytes .
23499875	0	glucose	5,12	TRPC6	55,60	glucose	TRPC6	MESH:D005947	7225	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|stimulating stimulating|dobj|END_ENTITY	High glucose induces podocyte apoptosis by stimulating TRPC6 via elevation of reactive oxygen species .
24731445	9	glucose	1288,1295	TRPC6	1237,1242	glucose	TRPC6	MESH:D005947	89823(Tax:10116)	Chemical	Gene	effect|compound|START_ENTITY demonstrated|dobj|effect demonstrated|nsubj|Studies Studies|nmod|construct construct|compound|END_ENTITY	Studies with a TRPC6 luciferase promoter construct demonstrated a glucose concentration-dependent effect on TRPC6 promoter activity .
26629404	0	glucose	48,55	TUSC5	0,5	glucose	TUSC5	MESH:D005947	286753	Chemical	Gene	uptake|compound|START_ENTITY regulates|dobj|uptake regulates|nsubj|END_ENTITY	TUSC5 regulates insulin-mediated adipose tissue glucose uptake by modulation of GLUT4 recycling .
17472435	0	glucose	27,34	TXNIP	0,5	glucose	TXNIP	MESH:D005947	10628	Chemical	Gene	metabolism|compound|START_ENTITY regulates|dobj|metabolism regulates|nsubj|END_ENTITY	TXNIP regulates peripheral glucose metabolism in humans .
17550776	0	glucose	31,38	TXNIP	0,5	glucose	TXNIP	MESH:D005947	10628	Chemical	Gene	control|compound|START_ENTITY links|nmod|control links|nsubj|END_ENTITY	TXNIP links redox circuitry to glucose control .
21448924	0	glucose	89,96	TXNIP	69,74	glucose	TXNIP	MESH:D005947	10628	Chemical	Gene	mechanism|compound|START_ENTITY MDA-MB-231|nsubj|mechanism mediate|xcomp|MDA-MB-231 mediate|nsubj|Wnt/b-catenin Wnt/b-catenin|appos|END_ENTITY	Wnt/b-catenin signaling pathway and thioredoxin-interacting_protein -LRB- TXNIP -RRB- mediate the `` glucose sensor '' mechanism in metastatic breast cancer-derived cells MDA-MB-231 .
23353834	0	glucose	97,104	TXNIP	17,22	glucose	TXNIP	MESH:D005947	117514(Tax:10116)	Chemical	Gene	damage|nmod|START_ENTITY END_ENTITY|nmod|damage	Critical role of TXNIP in oxidative stress , DNA damage and retinal pericyte apoptosis under high glucose : implications for diabetic_retinopathy .
23453806	0	glucose	73,80	TXNIP	30,35	glucose	TXNIP	MESH:D005947	10628	Chemical	Gene	uptake|compound|START_ENTITY leads|nmod|uptake leads|nsubj|degradation degradation|nmod|END_ENTITY	AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1 .
25870263	6	glucose	899,906	TXNIP	871,876	glucose	TXNIP	MESH:D005947	10628	Chemical	Gene	uptake|compound|START_ENTITY increases|dobj|uptake increases|nsubj|suppression suppression|compound|END_ENTITY	TXNIP suppression increases glucose uptake and drives a dependence on glycolysis .
26015432	0	glucose	40,47	Tbc1d1	24,30	glucose	Tbc1d1	MESH:D005947	57915(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY modifies|dobj|homeostasis modifies|nsubj|Deletion Deletion|nmod|END_ENTITY	Deletion of the Rab GAP Tbc1d1 modifies glucose , lipid and energy homeostasis in mice .
16178483	0	glucose	26,33	Tgf-beta1	0,9	glucose	Tgf-beta1	MESH:D005947	7040	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Tgf-beta1 induced by high glucose is controlled by angiotensin-converting enzyme inhibitor and angiotensin_II receptor blocker on cultured human peritoneal mesothelial cells .
15705778	0	glucose	49,56	Thioredoxin-interacting_protein	0,31	glucose	Thioredoxin-interacting protein	MESH:D005947	10628	Chemical	Gene	stimulated|nmod|START_ENTITY stimulated|nsubjpass|END_ENTITY	Thioredoxin-interacting_protein is stimulated by glucose through a carbohydrate response element and induces beta-cell apoptosis .
19052253	0	glucose	84,91	Thioredoxin-interacting_protein	0,31	glucose	Thioredoxin-interacting protein	MESH:D005947	10628	Chemical	Gene	upregulated|nmod|START_ENTITY END_ENTITY|parataxis|upregulated	Thioredoxin-interacting_protein : an oxidative stress-related gene is upregulated by glucose in human prostate_carcinoma cells .
22561086	0	glucose	58,65	Thioredoxin-interacting_protein	93,124	glucose	Thioredoxin-interacting protein	MESH:D005947	10628	Chemical	Gene	homeostasis|compound|START_ENTITY regulation|nmod|homeostasis mechanism|nmod|regulation mechanism|dep|inhibition inhibition|nmod|expression expression|amod|END_ENTITY	A potential mechanism of metformin-mediated regulation of glucose homeostasis : inhibition of Thioredoxin-interacting_protein -LRB- Txnip -RRB- gene expression .
23976953	0	glucose	42,49	Thioredoxin-interacting_protein	0,31	glucose	Thioredoxin-interacting protein	MESH:D005947	56338(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY regulates|dobj|metabolism regulates|nsubj|END_ENTITY	Thioredoxin-interacting_protein regulates glucose metabolism and affects cytoplasmic streaming in mouse oocytes .
9230074	0	glucose	20,27	Thrombin	0,8	glucose	Thrombin	MESH:D005947	2147	Chemical	Gene	transport|compound|START_ENTITY stimulates|dobj|transport stimulates|nsubj|END_ENTITY	Thrombin stimulates glucose transport in human platelets via the translocation of the glucose_transporter GLUT-3 from alpha-granules to the cell surface .
23993965	0	glucose	68,75	Tiam-1	0,6	glucose	Tiam-1	MESH:D005947	21844(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY role|nmod|uptake plays|dobj|role plays|nsubj|END_ENTITY	Tiam-1 , a GEF for Rac1 , plays a critical role in metformin-mediated glucose uptake in C2C12 cells .
19492426	0	glucose	33,40	Toll-like_receptor-4	64,84	glucose	Toll-like receptor-4	MESH:D005947	21898(Tax:10090)	Chemical	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Lipopolysaccharide inhibition of glucose production through the Toll-like_receptor-4 , myeloid_differentiation_factor_88 , and nuclear factor kappa b pathway .
20067961	0	glucose	31,38	Toll-like_receptor-4_and_suppressor_of_cytokine_signaling-3	107,166	glucose	Toll-like receptor-4 and suppressor of cytokine signaling-3	MESH:D005947	7099;9021	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Differential effects of cream , glucose , and orange juice on inflammation , endotoxin , and the expression of Toll-like_receptor-4_and_suppressor_of_cytokine_signaling-3 .
20416221	0	glucose	117,124	Toll-like_receptor_4	47,67	glucose	Toll-like receptor 4	MESH:D005947	29260(Tax:10116)	Chemical	Gene	-RSB-|compound|START_ENTITY exposed|nmod|-RSB- exposed|nsubj|Effect Effect|nmod|spironolactone spironolactone|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of spironolactone on the expression of Toll-like_receptor_4 in renal tubular epithelia cells exposed to high glucose -RSB- .
23041150	0	glucose	89,96	Toll-like_receptor_4	28,48	glucose	Toll-like receptor 4	MESH:D005947	7099	Chemical	Gene	condition|compound|START_ENTITY attenuates|nmod|condition attenuates|dobj|expression expression|compound|END_ENTITY	Astragaloside_IV attenuates Toll-like_receptor_4 expression via NF-kB pathway under high glucose condition in mesenchymal stem cells .
26468333	0	glucose	5,12	Toll-like_receptor_4	35,55	glucose	Toll-like receptor 4	MESH:D005947	7099	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	High glucose induces and activates Toll-like_receptor_4 in endothelial cells of diabetic_retinopathy .
1917944	0	glucose	45,52	Transforming_growth_factor-beta_1	0,33	glucose	Transforming growth factor-beta 1	MESH:D005947	21803(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY stimulates|dobj|uptake stimulates|nsubj|END_ENTITY	Transforming_growth_factor-beta_1 stimulates glucose uptake and the expression of glucose_transporter mRNA in quiescent Swiss mouse 3T3 cells .
24477458	0	glucose	36,43	Transglutaminase_2	0,18	glucose	Transglutaminase 2	MESH:D005947	7052	Chemical	Gene	metabolism|compound|START_ENTITY reprogramming|nmod|metabolism reprogramming|amod|END_ENTITY	Transglutaminase_2 reprogramming of glucose metabolism in mammary epithelial cells via activation of inflammatory signaling pathways .
25845379	0	glucose	38,45	Tribbles_homolog_3	0,18	glucose	Tribbles homolog 3	MESH:D005947	57761	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Tribbles_homolog_3 is induced by high glucose and associated with apoptosis in human endothelial cells .
10360633	0	glucose	35,42	Tumor_necrosis_factor-alpha	0,27	glucose	Tumor necrosis factor-alpha	MESH:D005947	24835(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY alters|dobj|metabolism alters|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha alters glucose metabolism in suckling rats .
14530204	0	glucose	69,76	Tumor_necrosis_factor-alpha	0,27	glucose	Tumor necrosis factor-alpha	MESH:D005947	7124	Chemical	Gene	uptake|nmod:npmod|START_ENTITY stimulating|nmod|uptake stimulating|nsubj|insulin insulin|amod|END_ENTITY	Tumor_necrosis_factor-alpha inhibits insulin 's stimulating effect on glucose uptake and endothelium-dependent vasodilation in humans .
7565637	0	glucose	60,67	Tumor_necrosis_factor-alpha	0,27	glucose	Tumor necrosis factor-alpha	MESH:D005947	21926(Tax:10090)	Chemical	Gene	utilization|compound|START_ENTITY utilization|compound|END_ENTITY	Tumor_necrosis_factor-alpha and interleukin-1_alpha enhance glucose utilization by astrocytes : involvement of phospholipase A2 .
20027290	0	glucose	94,101	Txnip	62,67	glucose	Txnip	MESH:D005947	10628	Chemical	Gene	molecules|compound|START_ENTITY response|nmod|molecules regulate|nmod|response regulate|dobj|expression expression|amod|END_ENTITY	Tandem ChoRE and CCAAT motifs and associated factors regulate Txnip expression in response to glucose or adenosine-containing molecules .
20511712	0	glucose	111,118	Txnip	11,16	glucose	Txnip	MESH:D005947	10628	Chemical	Gene	secretion|nummod|START_ENTITY Decreasing|nsubj|secretion Decreasing|dobj|mRNA mRNA|compound|END_ENTITY	Decreasing Txnip mRNA and protein levels in pancreatic MIN6 cells reduces reactive oxygen species and restores glucose regulated insulin secretion .
20558747	1	glucose	227,234	Txnip	152,157	glucose	Txnip	MESH:D005947	10628	Chemical	Gene	utilization|compound|START_ENTITY metabolism|nmod|utilization regulating|dobj|metabolism functions|acl|regulating has|dobj|functions has|nsubj|Thioredoxin-interacting_protein Thioredoxin-interacting_protein|appos|END_ENTITY	Thioredoxin-interacting_protein -LRB- Txnip -RRB- has important functions in regulating cellular metabolism including glucose utilization ; the expression of the Txnip gene is sensitive to the availability of glucose and other fuels .
20558747	1	glucose	317,324	Txnip	152,157	glucose	Txnip	MESH:D005947	10628	Chemical	Gene	fuels|compound|START_ENTITY availability|nmod|fuels sensitive|nmod|availability has|parataxis|sensitive has|nsubj|Thioredoxin-interacting_protein Thioredoxin-interacting_protein|appos|END_ENTITY	Thioredoxin-interacting_protein -LRB- Txnip -RRB- has important functions in regulating cellular metabolism including glucose utilization ; the expression of the Txnip gene is sensitive to the availability of glucose and other fuels .
20953987	0	glucose	5,12	Txnip	35,40	glucose	Txnip	MESH:D005947	117514(Tax:10116)	Chemical	Gene	condition|compound|START_ENTITY upregulated|nsubj|condition upregulated|dobj|level level|amod|END_ENTITY	High glucose condition upregulated Txnip expression level in rat mesangial cells through ROS/MEK/MAPK pathway .
22561086	0	glucose	58,65	Txnip	126,131	glucose	Txnip	MESH:D005947	10628	Chemical	Gene	homeostasis|compound|START_ENTITY regulation|nmod|homeostasis mechanism|nmod|regulation mechanism|dep|inhibition inhibition|nmod|expression expression|amod|Thioredoxin-interacting_protein Thioredoxin-interacting_protein|dep|END_ENTITY	A potential mechanism of metformin-mediated regulation of glucose homeostasis : inhibition of Thioredoxin-interacting_protein -LRB- Txnip -RRB- gene expression .
21787891	0	glucose	93,100	Tyk2	57,61	glucose	Tyk2	MESH:D005947	7297	Chemical	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	A comparative proteome analysis links tyrosine_kinase_2 -LRB- Tyk2 -RRB- to the regulation of cellular glucose and lipid metabolism in response to poly -LRB- I : C -RRB- .
11278970	0	glucose	39,46	Uncoupling_protein_3	0,20	glucose	Uncoupling protein 3	MESH:D005947	7352	Chemical	Gene	uptake|compound|START_ENTITY stimulates|dobj|uptake stimulates|nsubj|END_ENTITY	Uncoupling_protein_3 -LRB- UCP3 -RRB- stimulates glucose uptake in muscle cells through a phosphoinositide 3-kinase-dependent mechanism .
24116164	0	glucose	38,45	Urotensin_II	0,12	glucose	Urotensin II	MESH:D005947	24111(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY inhibits|dobj|transport inhibits|nsubj|END_ENTITY	Urotensin_II inhibits skeletal muscle glucose transport signaling pathways via the NADPH oxidase pathway .
11326319	0	glucose	16,23	VEGF	71,75	glucose	VEGF	MESH:D005947	7422	Chemical	Gene	uptake|compound|START_ENTITY Coregulation|nmod|uptake Coregulation|appos|END_ENTITY	Coregulation of glucose uptake and vascular_endothelial_growth_factor -LRB- VEGF -RRB- in two small-cell_lung_cancer -LRB- SCLC -RRB- sublines in vivo and in vitro .
11779150	0	glucose	5,12	VEGF	21,25	glucose	VEGF	MESH:D005947	22339(Tax:10090)	Chemical	Gene	induced|nsubj|START_ENTITY induced|dobj|expression expression|amod|END_ENTITY	High glucose induced VEGF expression via PKC_and_ERK in glomerular podocytes .
11944893	0	glucose	21,28	VEGF	71,75	glucose	VEGF	MESH:D005947	22339(Tax:10090)	Chemical	Gene	starvation|compound|START_ENTITY starvation|nmod|expression expression|nmod|mRNA mRNA|compound|END_ENTITY	Different effects of glucose starvation on expression and stability of VEGF mRNA isoforms in murine ovarian_cancer cells .
14579931	11	glucose	2214,2221	VEGF	2180,2184	glucose	VEGF	MESH:D005947	22339(Tax:10090)	Chemical	Gene	level|compound|START_ENTITY decrease|nmod|level followed|nsubjpass|decrease followed|nmod|absence absence|nmod|END_ENTITY	In contrast , in the absence of VEGF , the initial decrease in the glucose level was rapidly followed by a relapse in hyperglycemia .
15047143	0	glucose	16,23	VEGF	80,84	glucose	VEGF	MESH:D005947	83785(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY change|nmod|concentration promotes|nsubj|change promotes|dobj|proliferation proliferation|nmod|END_ENTITY	Rapid change of glucose concentration promotes mesangial cell proliferation via VEGF : inhibitory effects of thiazolidinedione .
16545694	6	glucose	1082,1089	VEGF	1093,1097	glucose	VEGF	MESH:D005947	7422	Chemical	Gene	effect|nmod|START_ENTITY overcome|dobj|effect overcome|nmod|synthesis synthesis|compound|END_ENTITY	Importantly , induction of HO-1 by hemin was able to overcome the inhibitory effect of high glucose on VEGF synthesis .
18780185	0	glucose	85,92	VEGF	19,23	glucose	VEGF	MESH:D005947	7422	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|effect effect|nmod|END_ENTITY	Critical effect of VEGF in the process of endothelial cell apoptosis induced by high glucose .
18798867	0	glucose	5,12	VEGF	24,28	glucose	VEGF	MESH:D005947	83785(Tax:10116)	Chemical	Gene	attenuates|compound|START_ENTITY END_ENTITY|nsubj|attenuates	High glucose attenuates VEGF expression in rat multipotent adult progenitor cells in association with inhibition of JAK2/STAT3 signalling .
19040082	0	glucose	114,121	VEGF	22,26	glucose	VEGF	MESH:D005947	281572(Tax:9913)	Chemical	Gene	-RSB-|compound|START_ENTITY exposed|nmod|-RSB- exposed|nsubj|Effect Effect|nmod|insulin insulin|nmod|expression expression|amod|END_ENTITY	-LSB- Effect of insulin on VEGF expression in bovine retinal microvascular endothelial cells exposed to normal or high glucose -RSB- .
19107574	0	glucose	15,22	VEGF	40,44	glucose	VEGF	MESH:D005947	83785(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY concentration|nmod|END_ENTITY	Effect of high glucose concentration on VEGF and PEDF expression in cultured retinal M ller cells .
19557019	0	glucose	5,12	VEGF	40,44	glucose	VEGF	MESH:D005947	281572(Tax:9913)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|amod|END_ENTITY	High glucose attenuates insulin-induced VEGF expression in bovine retinal microvascular endothelial cells .
19696171	0	glucose	63,70	VEGF	34,38	glucose	VEGF	MESH:D005947	281572(Tax:9913)	Chemical	Gene	conditions|compound|START_ENTITY upregulation|nmod|conditions upregulation|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of JAK2/STAT3-mediated VEGF upregulation under high glucose conditions by PEDF through a mitochondrial ROS pathway in vitro .
19765632	0	glucose	37,44	VEGF	13,17	glucose	VEGF	MESH:D005947	22339(Tax:10090)	Chemical	Gene	Mechanism|nmod|START_ENTITY Mechanism|nmod|expression expression|compound|END_ENTITY	Mechanism of VEGF expression by high glucose in proximal tubule epithelial cells .
20830305	0	glucose	87,94	VEGF	36,40	glucose	VEGF	MESH:D005947	7422	Chemical	Gene	procedure|compound|START_ENTITY Evidence|nmod|procedure Evidence|nmod|relationship relationship|nmod|END_ENTITY	Evidence for a relationship between VEGF and BMI independent of insulin sensitivity by glucose clamp procedure in a homogenous group healthy young men .
21158590	0	glucose	17,24	VEGF	54,58	glucose	VEGF	MESH:D005947	7422	Chemical	Gene	concentration|compound|START_ENTITY concentration|nmod|END_ENTITY	The influence of glucose concentration and hypoxia on VEGF secretion by cultured retinal cells .
22766709	0	glucose	85,92	VEGF	32,36	glucose	VEGF	MESH:D005947	83785(Tax:10116)	Chemical	Gene	conditions|compound|START_ENTITY cells|nmod|conditions effect|nmod|cells effect|nmod|production production|compound|END_ENTITY	The effect of astragalin on the VEGF production of cultured M ller cells under high glucose conditions .
22983702	8	glucose	1319,1326	VEGF	1237,1241	glucose	VEGF	MESH:D005947	7422	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|expressions expressions|nmod|vascular_endothelial_growth_factor vascular_endothelial_growth_factor|appos|END_ENTITY	Resveratrol also down-regulated the increased expressions of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and kinase_insert_domain_receptor -LRB- KDR , or VEGF receptor-2 -RRB- induced by high glucose .
24330582	0	glucose	72,79	VEGF	37,41	glucose	VEGF	MESH:D005947	7422	Chemical	Gene	deprivation|compound|START_ENTITY induces|nmod|deprivation induces|dobj|expression expression|amod|END_ENTITY	An aryl_hydrocarbon_receptor induces VEGF expression through ATF4 under glucose deprivation in HepG2 .
24402435	0	glucose	18,25	VEGF	94,98	glucose	VEGF	MESH:D005947	7422	Chemical	Gene	metabolism|compound|START_ENTITY integrates|dobj|metabolism integrates|advcl|regulating regulating|dobj|END_ENTITY	PGC-1a integrates glucose metabolism and angiogenesis in multiple_myeloma cells by regulating VEGF and GLUT-4 .
25743346	0	glucose	107,114	VEGF	0,4	glucose	VEGF	MESH:D005947	7422	Chemical	Gene	activation|compound|START_ENTITY conditions|nmod|activation impaired|nmod|conditions impaired|nsubjpass|secretion secretion|compound|END_ENTITY	VEGF secretion by adipose tissue-derived regenerative cells is impaired under hyperglycemic conditions via glucose transporter activation and ROS increase .
26936681	0	glucose	102,109	VEGF	18,22	glucose	VEGF	MESH:D005947	7422	Chemical	Gene	stimuli|compound|START_ENTITY apoptosis|nmod|stimuli apoptosis|nsubj|Downregulation Downregulation|nmod|END_ENTITY	Downregulation of VEGF and upregulation of TL1A expression induce HUVEC apoptosis in response to high glucose stimuli .
7976418	1	glucose	133,140	VIP	95,98	glucose	VIP	MESH:D005947	117064(Tax:10116)	Chemical	Gene	glucagon|dep|START_ENTITY glucagon|dep|END_ENTITY	Effects on plasma levels of oxytocin , prolactin , VIP , somatostatin , insulin , glucagon , glucose and of milk secretion in lactating rats .
12137907	0	glucose	98,105	Vascular_endothelial_growth_factor	0,34	glucose	Vascular endothelial growth factor	MESH:D005947	7422	Chemical	Gene	deprivation|compound|START_ENTITY up-regulated|nmod|deprivation up-regulated|nsubjpass|expression expression|amod|END_ENTITY	Vascular_endothelial_growth_factor gene expression in a retinal pigmented cell is up-regulated by glucose deprivation through 3 ' UTR .
15862172	0	glucose	104,111	Vascular_endothelial_growth_factor	0,34	glucose	Vascular endothelial growth factor	MESH:D005947	83785(Tax:10116)	Chemical	Gene	cells|nmod|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	Vascular_endothelial_growth_factor expression and secretion by retinal pigment epithelial cells in high glucose and hypoxia is protein_kinase_C-dependent .
8660335	0	glucose	64,71	Vascular_endothelial_growth_factor	0,34	glucose	Vascular endothelial growth factor	MESH:D005947	281572(Tax:9913)	Chemical	Gene	concentration|compound|START_ENTITY induced|nmod|concentration induced|nsubjpass|END_ENTITY	Vascular_endothelial_growth_factor is induced by long-term high glucose concentration and up-regulated by acute glucose deprivation in cultured bovine retinal pigmented epithelial cells .
17940983	0	glucose	45,52	Visfatin	0,8	glucose	Visfatin	MESH:D005947	10135	Chemical	Gene	test|compound|START_ENTITY change|nmod|test change|nsubj|levels levels|compound|END_ENTITY	Visfatin levels do not change after the oral glucose tolerance test and after a dexamethasone-induced increase in insulin resistance in humans .
16131485	0	glucose	47,54	Vti1a	12,17	glucose	Vti1a	MESH:D005947	143187	Chemical	Gene	transport|compound|START_ENTITY regulates|dobj|transport regulates|nsubj|END_ENTITY	The v-SNARE Vti1a regulates insulin-stimulated glucose transport and Acrp30 secretion in 3T3-L1 adipocytes .
24049067	0	glucose	81,88	WNT/b-catenin	49,62	glucose	WNT/b-catenin	MESH:D005947	1499	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	A new link between diabetes and cancer : enhanced WNT/b-catenin signaling by high glucose .
25012504	0	glucose	32,39	WWOX	17,21	glucose	WWOX	MESH:D005947	80707(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY regulates|dobj|metabolism regulates|nsubj|END_ENTITY	Tumor suppressor WWOX regulates glucose metabolism via HIF1a modulation .
15493009	0	glucose	43,50	ZO-1	18,22	glucose	ZO-1	MESH:D005947	396567(Tax:9823)	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|nmod|transporter	Reorganization of ZO-1 by sodium-dependent glucose transporter activation after heat stress in LLC-PK1 cells .
23700520	0	glucose	66,73	adenosine_A1_receptor	34,55	glucose	adenosine A1 receptor	MESH:D005947	11539(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|amod|END_ENTITY	Adipokines and central control in adenosine_A1_receptor dependent glucose metabolism .
12540592	0	glucose	70,77	adiponectin	7,18	glucose	adiponectin	MESH:D005947	9370	Chemical	Gene	metabolism|compound|START_ENTITY sensitivity|nmod|metabolism predict|dobj|sensitivity predict|nsubj|concentrations concentrations|compound|END_ENTITY	Plasma adiponectin concentrations predict insulin sensitivity of both glucose and lipid metabolism .
15301786	0	glucose	94,101	adiponectin	6,17	glucose	adiponectin	MESH:D005947	9370	Chemical	Gene	levels|nmod|START_ENTITY circulating|dobj|levels interactions|acl|circulating END_ENTITY|dep|interactions	Serum adiponectin in young adults -- interactions with central adiposity , circulating levels of glucose , and insulin resistance : the CARDIA study .
15331527	0	glucose	107,114	adiponectin	14,25	glucose	adiponectin	MESH:D005947	9370	Chemical	Gene	metabolism|compound|START_ENTITY parameters|nmod|metabolism related|nmod|parameters related|nsubjpass|Expression Expression|nmod|mRNA mRNA|compound|END_ENTITY	Expression of adiponectin receptor mRNA in human skeletal muscle cells is related to in vivo parameters of glucose and lipid metabolism .
15596567	0	glucose	26,33	adiponectin	93,104	glucose	adiponectin	MESH:D005947	9370	Chemical	Gene	metabolism|compound|START_ENTITY Multiple_abnormalities|nmod|metabolism Multiple_abnormalities|nmod|levels levels|nmod|cytokines cytokines|compound|END_ENTITY	Multiple_abnormalities in glucose and energy metabolism and coordinated changes in levels of adiponectin , cytokines , and adhesion molecules in subjects with metabolic_syndrome .
15652919	0	glucose	85,92	adiponectin	12,23	glucose	adiponectin	MESH:D005947	9370	Chemical	Gene	test|compound|START_ENTITY Decrease|nmod|test Decrease|nmod|levels levels|compound|END_ENTITY	Decrease in adiponectin levels in women with polycystic_ovary_syndrome after an oral glucose tolerance test .
15761178	0	glucose	69,76	adiponectin	7,18	glucose	adiponectin	MESH:D005947	9370	Chemical	Gene	tolerance|compound|START_ENTITY African-Americans|nmod|tolerance African-Americans|nsubj|levels levels|compound|END_ENTITY	Plasma adiponectin levels in high risk African-Americans with normal glucose tolerance , impaired_glucose_tolerance , and type 2 diabetes .
15855264	0	glucose	75,82	adiponectin	15,26	glucose	adiponectin	MESH:D005947	9370	Chemical	Gene	metabolism|compound|START_ENTITY gene|nmod|metabolism Association|nmod|gene Association|nmod|level level|compound|END_ENTITY	Association of adiponectin level and variants in the adiponectin gene with glucose metabolism , energy expenditure , and cytokines in offspring of type 2 diabetic patients .
15855264	0	glucose	75,82	adiponectin	53,64	glucose	adiponectin	MESH:D005947	9370	Chemical	Gene	metabolism|compound|START_ENTITY gene|nmod|metabolism gene|compound|END_ENTITY	Association of adiponectin level and variants in the adiponectin gene with glucose metabolism , energy expenditure , and cytokines in offspring of type 2 diabetic patients .
15862282	0	glucose	90,97	adiponectin	159,170	glucose	adiponectin	MESH:D005947	9370	Chemical	Gene	tolerance|compound|START_ENTITY polycystic_ovary_syndrome|nmod|tolerance test|amod|polycystic_ovary_syndrome women|nmod|test levels|nmod|women levels|dep|correlation correlation|nmod|independent independent|compound|END_ENTITY	Adiponectin and resistin serum levels in women with polycystic_ovary_syndrome during oral glucose tolerance test : a significant reciprocal correlation between adiponectin and resistin independent of insulin resistance indices .
15902402	0	glucose	74,81	adiponectin	109,120	glucose	adiponectin	MESH:D005947	9370	Chemical	Gene	tolerance|compound|START_ENTITY tolerance|nmod|END_ENTITY	Serum high molecular weight complex of adiponectin correlates better with glucose tolerance than total serum adiponectin in Indo-Asian males .
15902402	0	glucose	74,81	adiponectin	39,50	glucose	adiponectin	MESH:D005947	9370	Chemical	Gene	tolerance|compound|START_ENTITY correlates|nmod|tolerance correlates|nsubj|complex complex|nmod|END_ENTITY	Serum high molecular weight complex of adiponectin correlates better with glucose tolerance than total serum adiponectin in Indo-Asian males .
16061021	0	glucose	108,115	adiponectin	7,18	glucose	adiponectin	MESH:D005947	9370	Chemical	Gene	study|compound|START_ENTITY distribution|nmod|study relation|nmod|distribution concentration|nmod|relation concentration|compound|END_ENTITY	-LSB- Serum adiponectin concentration in relation to body fat distribution and tissue insulin sensitivity in the glucose clamp study -RSB- .
16234307	0	glucose	76,83	adiponectin	7,18	glucose	adiponectin	MESH:D005947	9370	Chemical	Gene	disposal|compound|START_ENTITY associated|nmod|disposal associated|nsubjpass|level level|compound|END_ENTITY	Plasma adiponectin level is associated with insulin-stimulated nonoxidative glucose disposal .
16249439	0	glucose	69,76	adiponectin	35,46	glucose	adiponectin	MESH:D005947	9370	Chemical	Gene	uptake|compound|START_ENTITY END_ENTITY|nmod|uptake	The stimulatory effect of globular adiponectin on insulin-stimulated glucose uptake and fatty_acid oxidation is impaired in skeletal muscle from obese subjects .
16423625	0	glucose	77,84	adiponectin	6,17	glucose	adiponectin	MESH:D005947	9370	Chemical	Gene	tolerance|compound|START_ENTITY END_ENTITY|nmod|tolerance	Serum adiponectin in a population sample of 64-year-old women in relation to glucose tolerance , family history of diabetes , autoimmunity , _ insulin_sensitivity , C-peptide , and inflammation .
16631275	0	glucose	153,160	adiponectin	78,89	glucose	adiponectin	MESH:D005947	9370	Chemical	Gene	tolerance|compound|START_ENTITY men|nmod|tolerance obese|appos|men END_ENTITY|nmod|obese	Increased oxidative stress is associated with decreased circulating levels of adiponectin in Japanese metabolically obese , normal-weight men with normal glucose tolerance .
16682836	0	glucose	74,81	adiponectin	12,23	glucose	adiponectin	MESH:D005947	9370	Chemical	Gene	control|compound|START_ENTITY relation|nmod|control therapy|nmod|relation Increase|nmod|therapy Increase|nmod|levels levels|compound|END_ENTITY	Increase in adiponectin levels during pioglitazone therapy in relation to glucose control , insulin resistance as well as ghrelin and resistin levels .
16801926	0	glucose	4,11	adiponectin	49,60	glucose	adiponectin	MESH:D005947	9370	Chemical	Gene	clamp|compound|START_ENTITY reveals|nsubj|clamp reveals|dobj|association association|nmod|polymorphisms polymorphisms|amod|END_ENTITY	The glucose clamp reveals an association between adiponectin gene polymorphisms and insulin sensitivity in obese subjects .
16918821	0	glucose	104,111	adiponectin	10,21	glucose	adiponectin	MESH:D005947	9370	Chemical	Gene	tolerance|compound|START_ENTITY END_ENTITY|nmod|tolerance	Are serum adiponectin concentrations in a population sample of 64-year-old Caucasian women with varying glucose tolerance associated with ultrasound-assessed atherosclerosis ?
17112529	0	glucose	21,28	adiponectin	74,85	glucose	adiponectin	MESH:D005947	9370	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|acl|associated associated|advcl|increasing increasing|dobj|END_ENTITY	Pravastatin improved glucose metabolism associated with increasing plasma adiponectin in patients with impaired_glucose_tolerance and coronary_artery_disease .
17322583	0	glucose	89,96	adiponectin	9,20	glucose	adiponectin	MESH:D005947	9370	Chemical	Gene	concentrations|compound|START_ENTITY cells|nmod|concentrations augments|nmod|cells augments|nsubj|END_ENTITY	Globular adiponectin augments insulin secretion from pancreatic islet beta cells at high glucose concentrations .
17356008	0	glucose	86,93	adiponectin	9,20	glucose	adiponectin	MESH:D005947	9370	Chemical	Gene	transport|compound|START_ENTITY develops|nmod|transport develops|nsubj|resistance resistance|compound|END_ENTITY	Globular adiponectin resistance develops independently of impaired insulin-stimulated glucose transport in soleus muscle from high-fat-fed rats .
17357284	0	glucose	125,132	adiponectin	7,18	glucose	adiponectin	MESH:D005947	9370	Chemical	Gene	metabolism|compound|START_ENTITY disturbances|nmod|metabolism patients|nmod|disturbances END_ENTITY|nmod|patients	Plasma adiponectin and E-selectin concentrations in patients with coronary_heart_disease and newly diagnosed disturbances of glucose metabolism .
17499232	0	glucose	74,81	adiponectin	34,45	glucose	adiponectin	MESH:D005947	9370	Chemical	Gene	mediate|nmod|START_ENTITY mediate|nsubj|forms forms|nmod|END_ENTITY	Globular and full-length forms of adiponectin mediate specific changes in glucose and fatty_acid uptake and metabolism in cardiomyocytes .
17663805	0	glucose	48,55	adiponectin	20,31	glucose	adiponectin	MESH:D005947	9370	Chemical	Gene	decreases|nmod|START_ENTITY decreases|nsubj|END_ENTITY	Postprandial plasma adiponectin decreases after glucose and high fat meal and is independently associated with postprandial triacylglycerols but not with -- 11388 promoter polymorphism .
17706206	0	glucose	83,90	adiponectin	25,36	glucose	adiponectin	MESH:D005947	9370	Chemical	Gene	tolerance|amod|START_ENTITY relationship|nmod|tolerance END_ENTITY|dep|relationship	Circulating and cellular adiponectin in polycystic_ovary_syndrome : relationship to glucose tolerance and insulin action .
17803698	0	glucose	73,80	adiponectin	38,49	glucose	adiponectin	MESH:D005947	9370	Chemical	Gene	metabolism|compound|START_ENTITY levels|nmod|metabolism END_ENTITY|dobj|levels	Total and high molecular weight -LRB- HMW -RRB- adiponectin levels and measures of glucose and lipid metabolism following pioglitazone treatment in a randomized placebo-controlled study in polycystic_ovary_syndrome .
18082632	0	glucose	97,104	adiponectin	49,60	glucose	adiponectin	MESH:D005947	9370	Chemical	Gene	tolerance|compound|START_ENTITY women|nmod|tolerance Influence|nmod|women Influence|nmod|concentrations concentrations|compound|END_ENTITY	Influence of age and visceral fat area on plasma adiponectin concentrations in women with normal glucose tolerance .
18389389	0	glucose	101,108	adiponectin	82,93	glucose	adiponectin	MESH:D005947	9370	Chemical	Gene	status|compound|START_ENTITY circulating|nmod|status circulating|dobj|END_ENTITY	Differences_in_insulin_sensitivity , pancreatic beta cell function and circulating adiponectin across glucose tolerance status in Thai obese_and_non-obese women .
18615850	0	glucose	32,39	adiponectin	9,20	glucose	adiponectin	MESH:D005947	9370	Chemical	Gene	transport|compound|START_ENTITY stimulates|dobj|transport stimulates|nsubj|END_ENTITY	Globular adiponectin stimulates glucose transport in type 2 diabetic muscle .
18787108	0	glucose	116,123	adiponectin	161,172	glucose	adiponectin	MESH:D005947	9370	Chemical	Gene	reduces|dobj|START_ENTITY tissue|acl:relcl|reduces CTRP9|nmod|tissue Identification|nmod|CTRP9 heterotrimers|nsubj|Identification heterotrimers|nmod|END_ENTITY	Identification and characterization of CTRP9 , a novel secreted glycoprotein , from adipose tissue that reduces serum glucose in mice and forms heterotrimers with adiponectin .
19592051	0	glucose	110,117	adiponectin	28,39	glucose	adiponectin	MESH:D005947	9370	Chemical	Gene	tolerance|compound|START_ENTITY subjects|nmod|tolerance load|nmod|subjects decreases|nmod|load decreases|nsubj|END_ENTITY	Serum high-molecular weight adiponectin decreases abruptly after an oral glucose load in subjects with normal glucose tolerance or impaired fasting glucose , but not those with impaired_glucose_tolerance or diabetes_mellitus .
19592051	0	glucose	73,80	adiponectin	28,39	glucose	adiponectin	MESH:D005947	9370	Chemical	Gene	load|compound|START_ENTITY decreases|nmod|load decreases|nsubj|END_ENTITY	Serum high-molecular weight adiponectin decreases abruptly after an oral glucose load in subjects with normal glucose tolerance or impaired fasting glucose , but not those with impaired_glucose_tolerance or diabetes_mellitus .
19650786	0	glucose	85,92	adiponectin	53,64	glucose	adiponectin	MESH:D005947	9370	Chemical	Gene	load|compound|START_ENTITY END_ENTITY|nmod|load	Dynamics of Nampt/visfatin and high molecular weight adiponectin in response to oral glucose load in obese and lean women .
19690066	0	glucose	65,72	adiponectin	36,47	glucose	adiponectin	MESH:D005947	9370	Chemical	Gene	metabolism|compound|START_ENTITY improve|dobj|metabolism improve|nsubj|increase increase|nmod|END_ENTITY	A rosiglitazone-induced increase in adiponectin does not improve glucose metabolism in HIV-infected patients with overt lipoatrophy .
19850242	0	glucose	91,98	adiponectin	22,33	glucose	adiponectin	MESH:D005947	9370	Chemical	Gene	tolerance|compound|START_ENTITY individuals|nmod|tolerance inflammation|nmod|individuals inflammation|nsubj|differences differences|nmod|END_ENTITY	Gender differences in adiponectin and low-grade inflammation among individuals with normal glucose tolerance , prediabetes , and type 2 diabetes .
20154025	0	glucose	18,25	adiponectin	65,76	glucose	adiponectin	MESH:D005947	9370	Chemical	Gene	exacerbates|nsubj|START_ENTITY exacerbates|dobj|production production|nmod|END_ENTITY	Intermittent high glucose exacerbates the aberrant production of adiponectin and resistin through mitochondrial superoxide overproduction in adipocytes .
21609588	0	glucose	17,24	adiponectin	61,72	glucose	adiponectin	MESH:D005947	9370	Chemical	Gene	rate|amod|START_ENTITY Relationship|nmod|rate Relationship|nmod|END_ENTITY	-LSB- Relationship of glucose metabolic rate and plasma levels of adiponectin and leptin in patients with metabolic_syndrome -RSB- .
21656264	0	glucose	58,65	adiponectin	137,148	glucose	adiponectin	MESH:D005947	9370	Chemical	Gene	secretion|compound|START_ENTITY secretion|nmod|level level|compound|END_ENTITY	Circulating osteocalcin level is associated with improved glucose tolerance , insulin secretion and sensitivity independent of the plasma adiponectin level .
22253614	0	glucose	27,34	adiponectin	12,23	glucose	Adiponectin	MESH:D005947	9370	Chemical	Gene	status|compound|START_ENTITY Relation|nmod|status Relation|nmod|END_ENTITY	Relation of adiponectin to glucose tolerance status , adiposity , and cardiovascular_risk factor load .
22396200	0	glucose	85,92	adiponectin	10,21	glucose	adiponectin	MESH:D005947	9370	Chemical	Gene	concentration|compound|START_ENTITY associated|nmod|concentration associated|nsubjpass|levels levels|compound|END_ENTITY	Placental adiponectin gene DNA methylation levels are associated with mothers ' blood glucose concentration .
22561436	0	glucose	87,94	adiponectin	17,28	glucose	adiponectin	MESH:D005947	9370	Chemical	Gene	-RSB-|compound|START_ENTITY combined|nmod|-RSB- combined|nsubj|level level|nmod|END_ENTITY	-LSB- Plasma level of adiponectin in coronary_heart_disease patients combined with abnormal glucose metabolism -RSB- .
22615828	0	glucose	119,126	adiponectin	22,33	glucose	adiponectin	MESH:D005947	9370	Chemical	Gene	comparable|nmod|START_ENTITY comparable|nmod|use use|nmod|END_ENTITY	Combined use of serum adiponectin and tumor necrosis factor-alpha receptor 2 levels was comparable to 2-hour post-load glucose in diabetes_prediction .
23049674	0	glucose	46,53	adiponectin	12,23	glucose	adiponectin	MESH:D005947	9370	Chemical	Gene	lower|dobj|START_ENTITY lower|nsubj|END_ENTITY	Recombinant adiponectin does not lower plasma glucose in animal models of type 2 diabetes .
23217388	0	glucose	102,109	adiponectin	11,22	glucose	adiponectin	MESH:D005947	9370	Chemical	Gene	cultured|nmod|START_ENTITY cultured|nsubj|Effects Effects|nmod|END_ENTITY	Effects of adiponectin on oxidative stress and apoptosis in human cardiac myocytes cultured with high glucose .
23391310	0	glucose	54,61	adiponectin	41,52	glucose	adiponectin	MESH:D005947	9370	Chemical	Gene	START_ENTITY|ccomp|exercise exercise|nmod|END_ENTITY	Effects of habitual t ` ai chi exercise on adiponectin , glucose homeostasis , lipid profile , and atherosclerotic burden in individuals with cardiovascular_risk factors .
23676254	0	glucose	117,124	adiponectin	32,43	glucose	adiponectin	MESH:D005947	9370	Chemical	Gene	levels|compound|START_ENTITY individuals|nmod|levels levels|nmod|individuals levels|compound|END_ENTITY	Total and high molecular weight adiponectin levels and risk of cardiovascular_disease in individuals with high blood glucose levels .
23709749	0	glucose	49,56	adiponectin	9,20	glucose	adiponectin	MESH:D005947	9370	Chemical	Gene	uptake|compound|START_ENTITY induces|dobj|uptake induces|nsubj|END_ENTITY	Globular adiponectin induces LKB1/AMPK-dependent glucose uptake via actin cytoskeleton remodeling .
23732048	0	glucose	14,21	adiponectin	54,65	glucose	adiponectin	MESH:D005947	11450(Tax:10090)	Chemical	Gene	Modulation|nmod|START_ENTITY metabolism|nsubj|Modulation metabolism|nmod|cells cells|compound|END_ENTITY	Modulation of glucose and lipid metabolism by porcine adiponectin receptor 1-transgenic mesenchymal stromal cells in diet-induced obese mice .
24417945	0	glucose	14,21	adiponectin	47,58	glucose	adiponectin	MESH:D005947	9370	Chemical	Gene	homeostasis|compound|START_ENTITY homeostasis|nmod|END_ENTITY	Regulation of glucose and lipid homeostasis by adiponectin : effects on hepatocytes , pancreatic b cells and adipocytes .
24851895	0	glucose	145,152	adiponectin	12,23	glucose	adiponectin	MESH:D005947	9370	Chemical	Gene	-RSB-|compound|START_ENTITY cultured|nmod|-RSB- cultured|nsubj|Effects Effects|nmod|END_ENTITY	-LSB- Effects of adiponectin on endoplasmic_reticulum_stress-mediated apoptosis and cell cytoskeleton and its mechanism of podocytes cultured in high glucose -RSB- .
23874700	0	glucose	69,76	adiponectin_receptor	11,31	glucose	adiponectin receptor	MESH:D005947	42656(Tax:7227)	Chemical	Gene	metabolism|compound|START_ENTITY regulates|dobj|metabolism regulates|nsubj|END_ENTITY	Drosophila adiponectin_receptor in insulin producing cells regulates glucose and lipid metabolism by controlling insulin secretion .
17974626	0	glucose	51,58	agouti-related_peptide	14,36	glucose	agouti-related peptide	MESH:D005947	181	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Inhibition of agouti-related_peptide expression by glucose in a clonal_hypothalamic neuronal cell line is mediated by glycolysis , not oxidative phosphorylation .
1893493	0	glucose	93,100	albumin	25,32	glucose	albumin	MESH:D005947	213	Chemical	Gene	concentrations|nmod|START_ENTITY END_ENTITY|nmod|concentrations	Glycation of human serum albumin in long-term incubation with low and high concentrations of glucose .
6162139	0	glucose	12,19	alpha-fetoprotein	23,40	glucose	alpha-fetoprotein	MESH:D005947	174	Chemical	Gene	Relation|nmod|START_ENTITY Relation|nmod|END_ENTITY	Relation of glucose to alpha-fetoprotein in amniotic fluid .
16510136	0	glucose	18,25	alpha-glucosidase	31,48	glucose	alpha-glucosidase	MESH:D005947	69983(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|amod|END_ENTITY	Control of plasma glucose with alpha-glucosidase inhibitor attenuates oxidative stress and slows the progression of heart_failure in mice .
23833952	1	glucose	130,137	alpha-glucosidase	77,94	glucose	alpha-glucosidase	MESH:D005947	69983(Tax:10090)	Chemical	Gene	-RSB-|compound|START_ENTITY activity|nmod|-RSB- activity|amod|END_ENTITY	chinensis Rousi polysaccharide on alpha-glucosidase enzyme activity and level of blood glucose -RSB- .
409564	0	glucose	169,176	alpha-glucosidase	117,134	glucose	alpha-glucosidase	MESH:D005947	406131(Tax:7460)	Chemical	Gene	-RSB-|compound|START_ENTITY hemolymph|nmod|-RSB- activity|nmod|hemolymph activity|amod|END_ENTITY	-LSB- Determination of the kinetic parameters of enzyme inhibition of the K-type mechanism : application to the control of alpha-glucosidase activity of honeybee hemolymph by glucose -RSB- .
413666	0	glucose	60,67	alpha-glucosidase	30,47	glucose	alpha-glucosidase	MESH:D005947	406131(Tax:7460)	Chemical	Gene	Mixed|nmod|START_ENTITY Mixed|dobj|inhibition inhibition|nmod|activity activity|amod|END_ENTITY	-LSB- Mixed `` n '' type inhibition of alpha-glucosidase activity by glucose in hemolymph of honeybee prenymphs -RSB- .
18600029	0	glucose	98,105	alpha-smooth_muscle_actin	29,54	glucose	alpha-smooth muscle actin	MESH:D005947	25365(Tax:10116)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of mesangial cell alpha-smooth_muscle_actin expression in 3-dimensional matrix by high glucose and growth factors .
17882348	0	glucose	9,16	alpha-tocopherol_transfer_protein	44,77	glucose	alpha-tocopherol transfer protein	MESH:D005947	50500(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|acl|lacking lacking|dobj|END_ENTITY	Improved glucose metabolism in mice lacking alpha-tocopherol_transfer_protein .
11111846	0	glucose	50,57	alpha1A-adrenoceptor	8,28	glucose	alpha1A-adrenoceptor	MESH:D005947	29412(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Role of alpha1A-adrenoceptor in the regulation of glucose uptake into white adipocyte of rats in vitro .
11474559	0	glucose	74,81	alpha1A-adrenoceptor	41,61	glucose	alpha1A-adrenoceptor	MESH:D005947	11549(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY increase|dobj|uptake isoferulic_acid|xcomp|increase isoferulic_acid|advcl|END_ENTITY	Stimulatory effect of isoferulic_acid on alpha1A-adrenoceptor to increase glucose uptake into cultured myoblast C2C12 cell of mice .
15643563	0	glucose	66,73	alpha1A-adrenoceptor	14,34	glucose	alpha1A-adrenoceptor	MESH:D005947	11549(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY increase|dobj|uptake andrographolide|acl|increase END_ENTITY|nmod|andrographolide	Activation of alpha1A-adrenoceptor by andrographolide to increase glucose uptake in cultured myoblast C2C12 cells .
1407245	0	glucose	58,65	amylin	32,38	glucose	amylin	MESH:D005947	3375	Chemical	Gene	metabolism|amod|START_ENTITY relationship|nmod|metabolism action|dep|relationship action|nmod|END_ENTITY	Biological action of pancreatic amylin : relationship with glucose metabolism , diabetes , obesity and calcium metabolism .
1541237	0	glucose	92,99	amylin	38,44	glucose	amylin	MESH:D005947	24476(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY amyloid|nmod|metabolism amyloid|dobj|polypeptide polypeptide|appos|END_ENTITY	Effects of islet amyloid polypeptide -LRB- amylin -RRB- and calcitonin_gene-related_peptide -LRB- CGRP -RRB- on glucose metabolism in the rat .
1541239	0	glucose	60,67	amylin	11,17	glucose	amylin	MESH:D005947	24476(Tax:10116)	Chemical	Gene	Release|nmod|START_ENTITY Release|nmod|END_ENTITY	Release of amylin from perfused rat pancreas in response to glucose and glucagon .
16751350	0	glucose	70,77	amylin	18,24	glucose	amylin	MESH:D005947	3375	Chemical	Gene	secretion|compound|START_ENTITY balance|nmod|secretion maintaining|dobj|balance END_ENTITY|dep|maintaining	The physiology of amylin and insulin : maintaining the balance between glucose secretion and glucose uptake .
18624122	0	glucose	19,26	amylin	9,15	glucose	amylin	MESH:D005947	3375	Chemical	Gene	homeostasis|compound|START_ENTITY END_ENTITY|nmod|homeostasis	-LSB- Role of amylin in glucose homeostasis and its perspective use in diabetes management -RSB- .
2088891	0	glucose	75,82	amylin	10,16	glucose	amylin	MESH:D005947	3375	Chemical	Gene	gene-related|nmod|START_ENTITY gene-related|nsubj|Effect Effect|nmod|END_ENTITY	Effect of amylin and calcitonin gene-related peptide on insulin-stimulated glucose and calcium transport in the diaphragm .
21319343	0	glucose	48,55	amylin	20,26	glucose	amylin	MESH:D005947	3375	Chemical	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	Delayed response of amylin levels after an oral glucose challenge in children with Prader-Willi_syndrome .
2192706	0	glucose	79,86	amylin	14,20	glucose	amylin	MESH:D005947	24476(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY gene-related|nmod|transport gene-related|nsubj|effect effect|nmod|END_ENTITY	The effect of amylin and calcitonin gene-related peptide on insulin-stimulated glucose transport in the diaphragm .
22178829	0	glucose	73,80	amylin	18,24	glucose	amylin	MESH:D005947	3375	Chemical	Gene	states|compound|START_ENTITY changes|nmod|states changes|nsubj|Investigation Investigation|nmod|level level|compound|END_ENTITY	-LSB- Investigation of amylin level changes among obese patients at different glucose metabolic states and effects of rosiglitazone intervention -RSB- .
2249001	0	glucose	88,95	amylin	41,47	glucose	amylin	MESH:D005947	24476(Tax:10116)	Chemical	Gene	removal|compound|START_ENTITY polypeptide|nmod|removal polypeptide|dep|END_ENTITY	The effect of islet amyloid polypeptide -LRB- amylin -RRB- and calcitonin_gene-related_peptide on glucose removal in the anaesthetized rat and on insulin secretion from rat pancreatic islets in vitro .
8174707	0	glucose	80,87	amylin	10,16	glucose	amylin	MESH:D005947	24476(Tax:10116)	Chemical	Gene	rise|nmod|START_ENTITY rise|nsubj|suppresses suppresses|compound|END_ENTITY	Selective amylin antagonist suppresses rise in plasma lactate after intravenous glucose in the rat .
8771910	0	glucose	24,31	amylin	62,68	glucose	amylin	MESH:D005947	3375	Chemical	Gene	effect|nmod|START_ENTITY endovenous|nsubj|effect endovenous|nmod|concentration concentration|compound|END_ENTITY	The effect of different glucose endovenous administrations on amylin and insulin blood concentration in healthy subjects .
9075803	0	glucose	61,68	amylin	43,49	glucose	amylin	MESH:D005947	3375	Chemical	Gene	profiles|compound|START_ENTITY pramlintide|nmod|profiles pramlintide|appos|analog analog|nmod|END_ENTITY	Effects of pramlintide , an analog of human amylin , on plasma glucose profiles in patients with IDDM : results of a multicenter trial .
9094752	0	glucose	13,20	amylin	63,69	glucose	amylin	MESH:D005947	24476(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY Influence|nmod|concentration Influence|nmod|effect effect|nmod|END_ENTITY	Influence of glucose concentration on the inhibitory effect of amylin on insulin secretion .
9212325	0	glucose	56,63	amylin	11,17	glucose	amylin	MESH:D005947	3375	Chemical	Gene	metabolism|compound|START_ENTITY pramlintide|nmod|metabolism pramlintide|nsubj|Effects Effects|nmod|END_ENTITY	Effects of amylin and the amylin agonist pramlintide on glucose metabolism .
9223392	0	glucose	65,72	amylin	21,27	glucose	amylin	MESH:D005947	3375	Chemical	Gene	reduced|dobj|START_ENTITY analogue|acl|reduced analogue|compound|END_ENTITY	Pramlintide : a human amylin analogue reduced postprandial plasma glucose , insulin , and C-peptide concentrations in patients with type 2 diabetes .
9389419	0	glucose	138,145	amylin	59,65	glucose	amylin	MESH:D005947	3375	Chemical	Gene	profiles|compound|START_ENTITY effects|nmod|profiles Effects|dep|effects Effects|nmod|administration administration|nmod|pramlintide pramlintide|appos|analogue analogue|compound|END_ENTITY	Effects of 4 weeks ' administration of pramlintide , a human amylin analogue , on glycaemia control in patients with IDDM : effects on plasma glucose profiles and serum fructosamine concentrations .
10330051	0	glucose	59,66	angiotensin_II	14,28	glucose	angiotensin II	MESH:D005947	24179(Tax:10116)	Chemical	Gene	isoforms|nmod|START_ENTITY isoforms|nsubj|Regulation Regulation|nmod|receptors receptors|amod|END_ENTITY	Regulation of angiotensin_II receptors and PKC isoforms by glucose in rat mesangial cells .
11115780	0	glucose	69,76	angiotensin_II	30,44	glucose	angiotensin II	MESH:D005947	24179(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY effects|nmod|metabolism interactions|dep|effects interactions|nmod|END_ENTITY	Possible interactions between angiotensin_II and insulin : effects on glucose and lipid metabolism in vivo and in vitro .
12660321	0	glucose	92,99	angiotensin_II	23,37	glucose	angiotensin II	MESH:D005947	24179(Tax:10116)	Chemical	Gene	cultured|nmod|START_ENTITY Mechanism|acl|cultured Mechanism|nmod|levels levels|compound|END_ENTITY	Mechanism of increased angiotensin_II levels in glomerular mesangial cells cultured in high glucose .
12661915	0	glucose	14,21	angiotensin_II	61,75	glucose	angiotensin II	MESH:D005947	183	Chemical	Gene	transporter|compound|START_ENTITY transporter|dep|expression expression|nmod|END_ENTITY	Regulation of glucose transporter -LRB- GLUT1 -RRB- gene expression by angiotensin_II in mesangial cells : involvement of HB-EGF_and_EGF_receptor transactivation .
15761243	0	glucose	15,22	angiotensin_II	71,85	glucose	angiotensin II	MESH:D005947	183	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|role role|nmod|END_ENTITY	Effect of high glucose on superoxide in human mesangial cells : role of angiotensin_II .
15921682	0	glucose	61,68	angiotensin_II	21,35	glucose	angiotensin II	MESH:D005947	24179(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY inhibits|dobj|uptake inhibits|nsubj|activation activation|nmod|END_ENTITY	ERK1/2 activation by angiotensin_II inhibits insulin-induced glucose uptake in vascular smooth muscle cells .
16310163	0	glucose	125,132	angiotensin_II	26,40	glucose	angiotensin II	MESH:D005947	24179(Tax:10116)	Chemical	Gene	conditions|compound|START_ENTITY cells|nmod|conditions mediates|nmod|cells mediates|dobj|induction induction|amod|END_ENTITY	Thrombospondin_1 mediates angiotensin_II induction of TGF-beta activation by cardiac and renal cells under both high and low glucose conditions .
16718629	0	glucose	19,26	angiotensin_II	61,75	glucose	angiotensin II	MESH:D005947	183	Chemical	Gene	loads|compound|START_ENTITY effect|nmod|loads effect|nmod|receptor receptor|amod|END_ENTITY	The effect of oral glucose loads on tissue metabolism during angiotensin_II receptor and beta-receptor blockade in obese hypertensive subjects .
17466950	0	glucose	83,90	angiotensin_II	28,42	glucose	angiotensin II	MESH:D005947	24179(Tax:10116)	Chemical	Gene	cultured|nmod|START_ENTITY cells|acl|cultured END_ENTITY|nmod|cells	Effect of ACE inhibitors on angiotensin_II in rat mesangial cells cultured in high glucose .
17626897	0	glucose	18,25	angiotensin_II	34,48	glucose	angiotensin II	MESH:D005947	24179(Tax:10116)	Chemical	Gene	START_ENTITY|acl|induced induced|dobj|production production|amod|END_ENTITY	Mechanism of high glucose induced angiotensin_II production in rat vascular smooth muscle cells .
19546347	0	glucose	14,21	angiotensin_II	84,98	glucose	angiotensin II	MESH:D005947	183	Chemical	Gene	uptake|compound|START_ENTITY Regulation|nmod|uptake Regulation|dep|role role|nmod|END_ENTITY	Regulation of glucose uptake in mesangial cells stimulated by high glucose : role of angiotensin_II and insulin .
19546347	0	glucose	67,74	angiotensin_II	84,98	glucose	angiotensin II	MESH:D005947	183	Chemical	Gene	stimulated|nmod|START_ENTITY cells|acl|stimulated uptake|nmod|cells Regulation|nmod|uptake Regulation|dep|role role|nmod|END_ENTITY	Regulation of glucose uptake in mesangial cells stimulated by high glucose : role of angiotensin_II and insulin .
19712706	0	glucose	65,72	angiotensin_II	28,42	glucose	angiotensin II	MESH:D005947	183	Chemical	Gene	effect|compound|START_ENTITY blocks|dobj|effect blocks|nsubj|Inhibition Inhibition|nmod|formation formation|compound|END_ENTITY	Inhibition of intracellular angiotensin_II formation blocks high glucose effect on mesangial matrix .
23324179	0	glucose	82,89	angiotensin_II	46,60	glucose	angiotensin II	MESH:D005947	183	Chemical	Gene	aldosterone|parataxis|START_ENTITY END_ENTITY|parataxis|aldosterone	AMP-activated protein kinase inhibits TGF-b - , angiotensin_II - , aldosterone - , high glucose - , and albumin-induced epithelial-mesenchymal transition .
2501766	0	glucose	37,44	angiotensin_II	133,147	glucose	angiotensin II	MESH:D005947	24179(Tax:10116)	Chemical	Gene	utilization|compound|START_ENTITY denervation|nmod|utilization Effects|nmod|denervation lobe|nsubj|Effects lobe|nmod|administration administration|nmod|END_ENTITY	Effects of sinoaortic denervation on glucose utilization in the subfornical organ and pituitary neural lobe during administration of angiotensin_II .
7573488	0	glucose	14,21	angiotensin_II	83,97	glucose	angiotensin II	MESH:D005947	24179(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|nmod|END_ENTITY	Extracellular glucose reduces the responsiveness of mesangial cell ion channels to angiotensin_II .
8214044	0	glucose	58,65	angiotensin_II	17,31	glucose	angiotensin II	MESH:D005947	183	Chemical	Gene	uptake|compound|START_ENTITY increase|dobj|uptake increase|nsubj|doses doses|nmod|END_ENTITY	Pressor doses of angiotensin_II increase insulin-mediated glucose uptake in normotensive men .
8267948	0	glucose	34,41	angiotensin_II	9,23	glucose	angiotensin II	MESH:D005947	183	Chemical	Gene	rate|compound|START_ENTITY increases|dobj|rate increases|nsubj|END_ENTITY	Low-dose angiotensin_II increases glucose disposal rate during euglycemic hyperinsulinemia .
8997162	0	glucose	20,27	angiotensin_II	45,59	glucose	angiotensin II	MESH:D005947	24179(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY concentration|nmod|growth growth|amod|END_ENTITY	The effects of high glucose concentration on angiotensin_II - or transforming growth factor-beta-induced DNA synthesis , hypertrophy and collagen synthesis in cultured rat mesangial cells .
9731749	0	glucose	14,21	angiotensin_II	35,49	glucose	angiotensin II	MESH:D005947	183	Chemical	Gene	transport|compound|START_ENTITY Regulation|nmod|transport Regulation|nmod|END_ENTITY	Regulation of glucose transport by angiotensin_II and glucose in cultured vascular smooth muscle cells .
9461091	0	glucose	10,17	angiotensinogen	43,58	glucose	angiotensinogen	MESH:D005947	183	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|gene gene|compound|END_ENTITY	Effect of glucose on the expression of the angiotensinogen gene in opossum kidney cells .
20180022	0	glucose	83,90	anion_exchanger-2	15,32	glucose	anion exchanger-2	MESH:D005947	6522	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of anion_exchanger-2 in apoptosis of endothelial cells induced by high glucose through an mPTP-ROS-Caspase-3 dependent pathway .
21395477	0	glucose	24,31	apelin	8,14	glucose	apelin	MESH:D005947	30878(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY controls|dobj|homeostasis controls|nsubj|END_ENTITY	Central apelin controls glucose homeostasis via a nitric_oxide-dependent pathway in mice .
22906703	0	glucose	72,79	apelin	42,48	glucose	apelin	MESH:D005947	30878(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod:poss|END_ENTITY	In vivo , ex vivo , and in vitro studies on apelin 's effect on myocardial glucose uptake .
23227256	0	glucose	8,15	apelin	63,69	glucose	apelin	MESH:D005947	8862	Chemical	Gene	homeostasis|compound|START_ENTITY associated|nsubjpass|homeostasis associated|nmod|levels levels|compound|END_ENTITY	Altered glucose homeostasis is associated with increased serum apelin levels in type_2_diabetes_mellitus .
23950038	0	glucose	68,75	apelin	24,30	glucose	apelin	MESH:D005947	8862	Chemical	Gene	homeostasis|compound|START_ENTITY insight|nmod|homeostasis actions|dep|insight actions|nmod|END_ENTITY	Hypothalamic actions of apelin on energy metabolism : new insight on glucose homeostasis and metabolic_disorders .
14988251	0	glucose	76,83	apolipoprotein_A-II	48,67	glucose	apolipoprotein A-II	MESH:D005947	336	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	In vitro transcriptional induction of the human apolipoprotein_A-II gene by glucose .
21183731	0	glucose	64,71	apolipoprotein_CIII	30,49	glucose	apolipoprotein CIII	MESH:D005947	345	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Transcriptional activation of apolipoprotein_CIII expression by glucose may contribute to diabetic_dyslipidemia .
11316863	0	glucose	88,95	aquaporin-1	14,25	glucose	aquaporin-1	MESH:D005947	358	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of aquaporin-1 in human peritoneal mesothelial cells and its upregulation by glucose in vitro .
12234316	0	glucose	89,96	aquaporin-3	14,25	glucose	aquaporin-3	MESH:D005947	360	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of aquaporin-3 in human peritoneal mesothelial cells and its up-regulation by glucose in vitro .
9110384	0	glucose	40,47	atrial_natriuretic_factor	11,36	glucose	atrial natriuretic factor	MESH:D005947	24602(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY Effects|nmod|metabolism Effects|nmod|END_ENTITY	Effects of atrial_natriuretic_factor on glucose metabolism in isolated adipocytes .
19074139	0	glucose	105,112	beta-Arrestin_1	0,15	glucose	beta-Arrestin 1	MESH:D005947	109689(Tax:10090)	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	beta-Arrestin_1 is required for PAC1 receptor-mediated potentiation of long-lasting ERK1/2 activation by glucose in pancreatic beta-cells .
12052528	0	glucose	61,68	beta-endorphin	11,25	glucose	beta-endorphin	MESH:D005947	18976(Tax:10090)	Chemical	Gene	lower|dobj|START_ENTITY gland|xcomp|lower gland|nsubj|Release Release|nmod|END_ENTITY	Release of beta-endorphin from adrenal gland to lower plasma glucose by the electroacupuncture at Zhongwan acupoint in rats .
1352555	0	glucose	94,101	beta-endorphin	55,69	glucose	beta-endorphin	MESH:D005947	5443	Chemical	Gene	utilization|compound|START_ENTITY changes|nmod|utilization mapped|nmod|changes receptors|amod|mapped receptors|amod|END_ENTITY	Neuroanatomical sites mediating the central actions of beta-endorphin as mapped by changes in glucose utilization : involvement of mu opioid receptors .
1666898	0	glucose	15,22	beta-endorphin	70,84	glucose	beta-endorphin	MESH:D005947	5443	Chemical	Gene	ingestion|compound|START_ENTITY effects|nmod|ingestion immunoreactive|nsubj|effects immunoreactive|xcomp|END_ENTITY	The effects of glucose ingestion and fasting on plasma immunoreactive beta-endorphin , adrenocorticotropic_hormone and cortisol in obese subjects .
1736041	0	glucose	56,63	beta-endorphin	35,49	glucose	beta-endorphin	MESH:D005947	5443	Chemical	Gene	metabolism|compound|START_ENTITY alter|dobj|metabolism alter|nsubj|elevations elevations|nmod|END_ENTITY	Physiological elevations of plasma beta-endorphin alter glucose metabolism in obese , but not normal-weight , subjects .
2028070	0	glucose	63,70	beta-endorphin	18,32	glucose	beta-endorphin	MESH:D005947	5443	Chemical	Gene	test|compound|START_ENTITY subjects|nmod|test END_ENTITY|nmod|subjects	-LSB- Plasma levels of beta-endorphin in obese subjects with normal glucose tolerance test and in diabetics -RSB- .
2531535	0	glucose	54,61	beta-endorphin	19,33	glucose	beta-endorphin	MESH:D005947	5443	Chemical	Gene	tolerance|compound|START_ENTITY END_ENTITY|nmod|tolerance	Response of plasma beta-endorphin and insulin to oral glucose tolerance test in non-obese women with polycystic_ovaries .
2885994	0	glucose	68,75	beta-endorphin	50,64	glucose	beta-endorphin	MESH:D005947	5443	Chemical	Gene	homeostasis|compound|START_ENTITY release|nmod|homeostasis release|nmod|effect effect|nmod|END_ENTITY	Primary role of glucagon release in the effect of beta-endorphin on glucose homeostasis in normal man .
2945622	0	glucose	51,58	beta-endorphin	15,29	glucose	beta-endorphin	MESH:D005947	5443	Chemical	Gene	Immunoreactive|nmod|START_ENTITY Immunoreactive|dobj|increases increases|amod|END_ENTITY	Immunoreactive beta-endorphin increases after i.v. glucose in obese human subjects .
2952663	0	glucose	45,52	beta-endorphin	89,103	glucose	beta-endorphin	MESH:D005947	5443	Chemical	Gene	insulin|compound|START_ENTITY determinants|nmod|insulin Hyperglycemia|nmod|determinants Hyperglycemia|nmod|END_ENTITY	Hyperglycemia and obesity as determinants of glucose , insulin , and glucagon responses to beta-endorphin in human diabetes_mellitus .
3034755	0	glucose	42,49	beta-endorphin	7,21	glucose	beta-endorphin	MESH:D005947	5443	Chemical	Gene	tolerance|compound|START_ENTITY response|nmod|tolerance END_ENTITY|nmod|response	Plasma beta-endorphin in response to oral glucose tolerance test in obese patients .
6099096	0	glucose	49,56	beta-endorphin	22,36	glucose	beta-endorphin	MESH:D005947	5443	Chemical	Gene	ingestion|compound|START_ENTITY immunoreactive|nmod|ingestion immunoreactive|dobj|response response|amod|END_ENTITY	Plasma immunoreactive beta-endorphin response to glucose ingestion in human obesity .
8055820	0	glucose	72,79	beta-endorphin	23,37	glucose	beta-endorphin	MESH:D005947	5443	Chemical	Gene	testing|compound|START_ENTITY Effect|nmod|testing Effect|nmod|concentrations concentrations|compound|END_ENTITY	-LSB- Effect of naloxone on beta-endorphin and insulin concentrations during glucose tolerance testing in patients with simple_obesity -RSB- .
8106616	0	glucose	67,74	beta-endorphin	35,49	glucose	beta-endorphin	MESH:D005947	5443	Chemical	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Insulin , C-peptide , androgens , and beta-endorphin response to oral glucose in patients with polycystic_ovary_syndrome .
9114466	0	glucose	48,55	beta-endorphin	10,24	glucose	beta-endorphin	MESH:D005947	18976(Tax:10090)	Chemical	Gene	peptides|nmod|START_ENTITY peptides|amod|END_ENTITY	Effect of beta-endorphin C-terminal peptides on glucose uptake in isolated skeletal muscles of the mouse .
9415073	0	glucose	61,68	beta-endorphin	34,48	glucose	beta-endorphin	MESH:D005947	18976(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY increase|dobj|uptake Evidence|acl|increase Evidence|nmod|action action|nmod|END_ENTITY	Evidence for a hormonal action of beta-endorphin to increase glucose uptake in resting and contracting skeletal muscle .
3159329	0	glucose	15,22	beta-hexosaminidase	38,57	glucose	beta-hexosaminidase	MESH:D005947	10724	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of glucose and insulin on beta-hexosaminidase in cultured fibroblasts from diabetic and non-diabetic subjects .
8903842	0	glucose	83,90	beta-hexosaminidase	7,26	glucose	beta-hexosaminidase	MESH:D005947	10724	Chemical	Gene	levels|compound|START_ENTITY exhibit|nmod|levels isoenzymes|ccomp|exhibit isoenzymes|advmod|END_ENTITY	Plasma beta-hexosaminidase isoenzymes A and B exhibit different relations to blood glucose levels in a population of Type 1 diabetic patients .
8907185	0	glucose	52,59	beta3-adrenoceptor	14,32	glucose	beta3-adrenoceptor	MESH:D005947	25645(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY Expression|nmod|transport Expression|nmod|END_ENTITY	Expression of beta3-adrenoceptor and stimulation of glucose transport by beta3-agonists in brown adipocyte primary culture .
7439330	0	glucose	22,29	bombesin	10,18	glucose	bombesin	MESH:D005947	2922	Chemical	Gene	system|compound|START_ENTITY Effect|nmod|system Effect|nmod|END_ENTITY	Effect of bombesin on glucose transport system in biomembranes .
18311072	0	glucose	86,93	bone_morphogenetic_protein-2	30,58	glucose	bone morphogenetic protein-2	MESH:D005947	650	Chemical	Gene	induced|nmod|START_ENTITY expression|acl|induced expression|amod|END_ENTITY	Pioglitazone can downregulate bone_morphogenetic_protein-2 expression induced by high glucose in human umbilical vein endothelial cells .
26937213	0	glucose	5,12	bone_morphogenic_protein_4	37,63	glucose	bone morphogenic protein 4	MESH:D005947	652	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	High glucose and palmitate increases bone_morphogenic_protein_4 expression in human endothelial cells .
10910005	0	glucose	64,71	bradykinin	15,25	glucose	bradykinin	MESH:D005947	3827	Chemical	Gene	uptake|compound|START_ENTITY increase|nmod|uptake END_ENTITY|nmod|increase	Involvement of bradykinin in acute exercise-induced increase of glucose uptake and GLUT-4 translocation in skeletal muscle : studies in normal and diabetic humans and rats .
1967418	0	glucose	33,40	bradykinin	19,29	glucose	bradykinin	MESH:D005947	3827	Chemical	Gene	metabolism|compound|START_ENTITY Effect|nmod|metabolism Effect|nmod|END_ENTITY	Effect of low-dose bradykinin on glucose metabolism and nitrogen balance in surgical patients .
2570343	0	glucose	21,28	bradykinin	64,74	glucose	bradykinin	MESH:D005947	3827	Chemical	Gene	production|compound|START_ENTITY production|dep|modulation modulation|nmod|infusion infusion|compound|END_ENTITY	Glucagon and hepatic glucose production : modulation by low-dose bradykinin infusion .
3123876	0	glucose	48,55	bradykinin	9,19	glucose	bradykinin	MESH:D005947	3827	Chemical	Gene	production|compound|START_ENTITY reduces|dobj|production reduces|nsubj|infusion infusion|compound|END_ENTITY	Low-dose bradykinin infusion reduces endogenous glucose production in surgical patients .
713429	0	glucose	29,36	bradykinin	50,60	glucose	bradykinin	MESH:D005947	3827	Chemical	Gene	tolerance|compound|START_ENTITY tolerance|nmod|END_ENTITY	-LSB- Improvement of pathological glucose tolerance by bradykinin in diabetics and in surgical patients -LRB- author 's transl -RRB- -RSB- .
870748	0	glucose	34,41	bradykinin	11,21	glucose	bradykinin	MESH:D005947	3827	Chemical	Gene	uptake|compound|START_ENTITY END_ENTITY|nmod|uptake	-LSB- Effect of bradykinin on muscular glucose uptake in man -LRB- author 's transl -RRB- -RSB- .
10647076	0	glucose	77,84	brain-derived_neurotrophic_factor	31,64	glucose	brain-derived neurotrophic factor	MESH:D005947	12064(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY ameliorates|dobj|metabolism ameliorates|nsubj|administration administration|nmod|END_ENTITY	Intermittent administration of brain-derived_neurotrophic_factor ameliorates glucose metabolism in obese diabetic mice .
18402781	0	glucose	99,106	brain-derived_neurotrophic_factor	6,39	glucose	brain-derived neurotrophic factor	MESH:D005947	627	Chemical	Gene	metabolism|compound|START_ENTITY Relationship|nmod|metabolism END_ENTITY|dep|Relationship	Serum brain-derived_neurotrophic_factor in patients with type_2_diabetes_mellitus : Relationship to glucose metabolism and biomarkers of insulin resistance .
18499057	0	glucose	84,91	brain-derived_neurotrophic_factor	31,64	glucose	brain-derived neurotrophic factor	MESH:D005947	12064(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY ameliorates|dobj|metabolism ameliorates|nsubj|administration administration|nmod|END_ENTITY	Intermittent administration of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- ameliorates glucose metabolism and prevents pancreatic exhaustion in diabetic mice .
10823814	0	glucose	16,23	c-Myc	72,77	glucose	c-Myc	MESH:D005947	4609	Chemical	Gene	Deregulation|nmod|START_ENTITY transporter|nsubj|Deregulation transporter|advcl|END_ENTITY	Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc .
11457846	0	glucose	5,12	c-Myc	44,49	glucose	c-Myc	MESH:D005947	24577(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	High glucose stimulates early response gene c-Myc expression in rat pancreatic beta cells .
18471412	0	glucose	65,72	c-met	15,20	glucose	c-met	MESH:D005947	4233	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Expression Expression|nmod|END_ENTITY	-LSB- Expression of c-met in human kidney fibroblasts induced by high glucose in vitro and the regulation of Radix Astragali -RSB- .
11714718	0	glucose	66,73	c-myc	42,47	glucose	c-myc	MESH:D005947	24577(Tax:10116)	Chemical	Gene	kinase|nmod|START_ENTITY kinase|nmod|induction induction|amod|END_ENTITY	Involvement of protein kinase C beta 2 in c-myc induction by high glucose in pancreatic beta-cells .
14651961	0	glucose	25,32	c-myc	101,106	glucose	c-myc	MESH:D005947	24577(Tax:10116)	Chemical	Gene	culture|nmod|START_ENTITY induces|nsubj|culture induces|nmod|induction induction|nmod|END_ENTITY	Prolonged culture in low glucose induces apoptosis of rat pancreatic beta-cells through induction of c-myc .
1777128	0	glucose	10,17	c-myc	39,44	glucose	c-myc	MESH:D005947	4609	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|gene gene|amod|END_ENTITY	Effect of glucose on the expression of c-myc gene in cultured RINm5F cell .
1872950	0	glucose	13,20	c-myc	34,39	glucose	c-myc	MESH:D005947	24577(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Elevation of glucose transporter , c-myc , and transin RNA levels by Ha-rasT24 is independent of its effect on the cell cycle .
2558650	0	glucose	54,61	c-myc	0,5	glucose	c-myc	MESH:D005947	4609	Chemical	Gene	controlled|nmod|START_ENTITY controlled|nsubjpass|expression expression|amod|END_ENTITY	c-myc gene expression in human cells is controlled by glucose .
8060330	0	glucose	9,16	c-myc	72,77	glucose	c-myc	MESH:D005947	24577(Tax:10116)	Chemical	Gene	concentrations|compound|START_ENTITY inhibit|nsubj|concentrations inhibit|dobj|synthesis synthesis|nmod|END_ENTITY	Elevated glucose concentrations inhibit DNA synthesis and expression of c-myc in cultured hepatocytes .
1962819	0	glucose	86,93	cAMP	66,70	glucose	cAMP	MESH:D005947	316010(Tax:10116)	Chemical	Gene	increase|nmod|START_ENTITY increase|nmod|END_ENTITY	Thiol reagents -LRB- diamide and N-ethylmaleimide -RRB- inhibit increase in cAMP in response to glucose and abolish the clonidine-mediated attenuation of glucagon-induced cAMP formation in isolated rat pancreatic islets .
7934825	0	glucose	59,66	cAMP_receptor_protein	27,48	glucose	cAMP receptor protein	MESH:D005947	20468888	Chemical	Gene	caused|nmod|START_ENTITY END_ENTITY|acl|caused	A lowered concentration of cAMP_receptor_protein caused by glucose is an important determinant for catabolite repression in Escherichia_coli .
1513334	0	glucose	55,62	cachectin	41,50	glucose	cachectin	MESH:D005947	24835(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	Effects of tumour necrosis factor-alpha -LRB- cachectin -RRB- on glucose metabolism in the rat .
2195296	0	glucose	63,70	cachectin	50,59	glucose	cachectin	MESH:D005947	24835(Tax:10116)	Chemical	Gene	turnover|compound|START_ENTITY END_ENTITY|nmod|turnover	Effect of interleukin-1_and_tumor_necrosis_factor / cachectin on glucose turnover in the rat .
17200159	0	glucose	80,87	calmodulin	66,76	glucose	calmodulin	MESH:D005947	808	Chemical	Gene	uptake|compound|START_ENTITY END_ENTITY|nmod|uptake	Profiling of human mesangial cell subproteomes reveals a role for calmodulin in glucose uptake .
12137596	0	glucose	76,83	calpain-10	22,32	glucose	calpain-10	MESH:D005947	11132	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Relationship between calpain-10 gene polymorphism , hypertension and plasma glucose -RSB- .
22012129	0	glucose	13,20	calpain_10	49,59	glucose	calpain 10	MESH:D005947	63834(Tax:10116)	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	Chronic high glucose downregulates mitochondrial calpain_10 and contributes to renal cell death and diabetes-induced renal_injury .
14742444	0	glucose	98,105	carbohydrate_response_element-binding_protein	49,94	glucose	carbohydrate response element-binding protein	MESH:D005947	51085	Chemical	Gene	regulation|compound|START_ENTITY END_ENTITY|nmod|regulation	Mlx is the functional heteromeric partner of the carbohydrate_response_element-binding_protein in glucose regulation of lipogenic enzyme genes .
20375990	0	glucose	5,12	carbohydrate_response_element_binding_protein	98,143	glucose	carbohydrate response element binding protein	MESH:D005947	58805(Tax:10090)	Chemical	Gene	activates|nsubj|START_ENTITY activates|nmod|END_ENTITY	High glucose activates HIF-1-mediated signal transduction in glomerular_mesangial_cells through a carbohydrate_response_element_binding_protein .
25285996	0	glucose	41,48	carboxylesterase_1	8,26	glucose	carboxylesterase 1	MESH:D005947	12623(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Hepatic carboxylesterase_1 is induced by glucose and regulates postprandial glucose levels .
23277190	0	glucose	63,70	cardiotrophin-1	44,59	glucose	cardiotrophin-1	MESH:D005947	1489	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|nmod|transport	Dual effect of the heart-targeting cytokine cardiotrophin-1 on glucose transport in cardiomyocytes .
15276325	0	glucose	43,50	catalase	18,26	glucose	catalase	MESH:D005947	12359(Tax:10090)	Chemical	Gene	concomitant|compound|START_ENTITY alters|dobj|concomitant alters|nsubj|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of catalase or Bcl-2 alters glucose and energy metabolism concomitant with dexamethasone resistance .
15497133	0	glucose	56,63	catalase	77,85	glucose	catalase	MESH:D005947	847	Chemical	Gene	bioreactor|nmod|START_ENTITY production|nmod|bioreactor oxidase|nsubj|production oxidase|dobj|END_ENTITY	Gluconic_acid production in bioreactor with immobilized glucose oxidase plus catalase on polymer membrane adjacent to anion-exchange_membrane .
23306382	0	glucose	78,85	catalase	41,49	glucose	catalase	MESH:D005947	24248(Tax:10116)	Chemical	Gene	responsiveness|compound|START_ENTITY interfere|nmod|responsiveness interfere|nsubj|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of the antioxidant enzyme catalase does not interfere with the glucose responsiveness of insulin-secreting INS-1E cells and rat islets .
427262	0	glucose	12,19	catalase	29,37	glucose	catalase	MESH:D005947	847	Chemical	Gene	oxidase|compound|START_ENTITY oxidase|dep|END_ENTITY	Immobilized glucose oxidase -- catalase and their deactivation in a differential-bed loop reactor .
43733	0	glucose	45,52	catalase	24,32	glucose	catalase	MESH:D005947	847	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	Restoration of red cell catalase activity by glucose metabolism after exposure to a vitamin_K analog .
18619973	0	glucose	5,12	cathepsin_L	21,32	glucose	cathepsin L	MESH:D005947	1514	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|activity activity|amod|END_ENTITY	High glucose reduces cathepsin_L activity and impairs invasion of circulating progenitor cells .
19816600	0	glucose	68,75	caveolin-1	109,119	glucose	caveolin-1	MESH:D005947	857	Chemical	Gene	concentration|nmod|START_ENTITY induced|nmod|concentration cells|acl|induced Apoptosis|nmod|cells associated|nsubjpass|Apoptosis associated|nmod|decrease decrease|nmod|levels levels|amod|END_ENTITY	Apoptosis of lens epithelial cells induced by high concentration of glucose is associated with a decrease in caveolin-1 levels .
23774524	0	glucose	31,38	caveolin-1	60,70	glucose	caveolin-1	MESH:D005947	399006(Tax:8355)	Chemical	Gene	SGLT1|compound|START_ENTITY coupled|dobj|SGLT1 coupled|advcl|END_ENTITY	Up-regulation of Na -LRB- + -RRB- - coupled glucose transporter SGLT1 by caveolin-1 .
1494491	0	glucose	38,45	cholecystokinin	12,27	glucose	cholecystokinin	MESH:D005947	25298(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY role|nmod|production role|nmod|END_ENTITY	The role of cholecystokinin -LRB- CCK8 -RRB- on glucose production and elimination , and on plasma insulin and glucose in rats .
19656488	0	glucose	36,43	cholecystokinin	11,26	glucose	cholecystokinin	MESH:D005947	885	Chemical	Gene	production|compound|START_ENTITY controls|dobj|production controls|nsubj|END_ENTITY	Intestinal cholecystokinin controls glucose production through a neuronal network .
24389993	0	glucose	106,113	cholecystokinin	115,130	glucose	cholecystokinin	MESH:D005947	885	Chemical	Gene	ghrelin|compound|START_ENTITY ghrelin|dep|END_ENTITY	Effects of miglitol , vildagliptin , or their combination on serum insulin and peptide_YY levels and plasma glucose , cholecystokinin , ghrelin , and obestatin levels .
3208828	0	glucose	57,64	cholecystokinin	23,38	glucose	cholecystokinin	MESH:D005947	25298(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|compound|END_ENTITY	Proglumide antagonizes cholecystokinin effects on plasma glucose and insulin in rats in vivo .
8492713	0	glucose	60,67	cholecystokinin	18,33	glucose	cholecystokinin	MESH:D005947	885	Chemical	Gene	tolerance|compound|START_ENTITY concentrations|nmod|tolerance concentrations|compound|END_ENTITY	Changes in plasma cholecystokinin concentrations after oral glucose tolerance test in anorexia_nervosa before and after therapy .
8596489	0	glucose	5,12	cholecystokinin	34,49	glucose	cholecystokinin	MESH:D005947	885	Chemical	Gene	ingestion|compound|START_ENTITY stimulates|nsubj|ingestion stimulates|dobj|release release|compound|END_ENTITY	Oral glucose ingestion stimulates cholecystokinin release in normal subjects and patients with non-insulin-dependent_diabetes_mellitus .
8997348	0	glucose	73,80	cholecystokinin	8,23	glucose	cholecystokinin	MESH:D005947	25298(Tax:10116)	Chemical	Gene	delivery|nmod|START_ENTITY produced|nmod|delivery produced|nsubj|Role Role|nmod|END_ENTITY	Role of cholecystokinin in the anorexia produced by duodenal delivery of glucose in rats .
21786536	0	glucose	6,13	chymase	65,72	glucose	chymase	MESH:D005947	1215	Chemical	Gene	START_ENTITY|nmod|transgenic_mice transgenic_mice|compound|END_ENTITY	Blood glucose level and survival in streptozotocin-treated human chymase transgenic_mice .
20403881	0	glucose	62,69	claudin-1	51,60	glucose	claudin-1	MESH:D005947	608207(Tax:9615)	Chemical	Gene	transporter|amod|START_ENTITY transporter|amod|END_ENTITY	Immunohistochemical detection of CD34 , E-cadherin , claudin-1 , glucose transporter 1 , laminin , and protein gene product 9.5 in 28 canine and 8 feline meningiomas .
4005226	0	glucose	45,52	connective_tissue_activating_peptide_III	66,106	glucose	connective tissue activating peptide III	MESH:D005947	5473	Chemical	Gene	transport|compound|START_ENTITY transport|nmod|END_ENTITY	Connective tissue activation : stimulation of glucose transport by connective_tissue_activating_peptide_III .
10026205	0	glucose	54,61	connective_tissue_growth_factor	101,132	glucose	connective tissue growth factor	MESH:D005947	1490	Chemical	Gene	levels|compound|START_ENTITY identifies|dobj|levels identifies|nmod|stimulus stimulus|nmod|expression expression|nmod|END_ENTITY	Suppression subtractive hybridization identifies high glucose levels as a stimulus for expression of connective_tissue_growth_factor and other genes in human mesangial cells .
11584370	0	glucose	5,12	connective_tissue_growth_factor	44,75	glucose	connective tissue growth factor	MESH:D005947	1490	Chemical	Gene	stimulate|nsubj|START_ENTITY stimulate|dobj|expression expression|compound|END_ENTITY	High glucose and hyperinsulinemia stimulate connective_tissue_growth_factor expression : a potential mechanism involved in progression to fibrosis in nonalcoholic_steatohepatitis .
12875721	0	glucose	15,22	connective_tissue_growth_factor	93,124	glucose	connective tissue growth factor	MESH:D005947	64032(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY antagonist|nsubj|Effect antagonist|nmod|expression expression|nmod|END_ENTITY	Effect of high glucose , angiotensin_II and receptor antagonist Losartan on the expression of connective_tissue_growth_factor in cultured mesangial cells .
16778968	0	glucose	6,13	connective_tissue_growth_factor	42,73	glucose	connective tissue growth factor	MESH:D005947	14219(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	-LSB- High glucose regulates the expression of connective_tissue_growth_factor and its receptor -LRB- low density lipoprotein receptor-related protein -RRB- in cultured podocytes -RSB- .
17224075	0	glucose	5,12	connective_tissue_growth_factor	25,56	glucose	connective tissue growth factor	MESH:D005947	1490	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	High glucose upregulates connective_tissue_growth_factor expression in human vascular smooth muscle cells .
19218111	0	glucose	16,23	connective_tissue_growth_factor	36,67	glucose	connective tissue growth factor	MESH:D005947	1490	Chemical	Gene	exposure|compound|START_ENTITY exposure|nmod|expression expression|compound|END_ENTITY	-LSB- Effect of high glucose exposure on connective_tissue_growth_factor expression in cultured human renal tubular epithelial cells and the role of p38MAPK pathway -RSB- .
19301817	0	glucose	101,108	connective_tissue_growth_factor	131,162	glucose	connective tissue growth factor	MESH:D005947	1490	Chemical	Gene	inhibits|nmod|START_ENTITY inhibits|parataxis|involves involves|dobj|signals signals|compound|END_ENTITY	Hibiscus sabdariffa inhibits vascular smooth muscle cell proliferation and migration induced by high glucose -- a mechanism involves connective_tissue_growth_factor signals .
19625611	0	glucose	24,31	connective_tissue_growth_factor	86,117	glucose	connective tissue growth factor	MESH:D005947	64032(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY mediated|nsubjpass|effects mediated|nmod|END_ENTITY	Adverse effects of high glucose and free fatty_acid on cardiomyocytes are mediated by connective_tissue_growth_factor .
23946690	0	glucose	5,12	connective_tissue_growth_factor	21,52	glucose	connective tissue growth factor	MESH:D005947	64032(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	High glucose induces connective_tissue_growth_factor expression and extracellular matrix accumulation in rat aorta vascular smooth muscle cells via extracellular_signal-regulated_kinase_1 / 2 .
25039149	0	glucose	135,142	connective_tissue_growth_factor	62,93	glucose	connective tissue growth factor	MESH:D005947	64032(Tax:10116)	Chemical	Gene	transforming|nmod|START_ENTITY CTGF|advcl|transforming CTGF|nmod|END_ENTITY	-LSB- Effect of tetramethylpyrazine and rat CTGF miRNA plasmids on connective_tissue_growth_factor , transforming growth factor-beta in high glucose stimulated hepatic stellate cells -RSB- .
11978657	0	glucose	49,56	connexin_43	18,29	glucose	connexin 43	MESH:D005947	24392(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Downregulation of connexin_43 expression by high glucose reduces gap junction activity in microvascular endothelial cells .
14638741	0	glucose	5,12	connexin_43	20,31	glucose	connexin 43	MESH:D005947	2697	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|expression expression|amod|END_ENTITY	High glucose alters connexin_43 expression and gap junction intercellular communication activity in retinal pericytes .
15123628	0	glucose	5,12	connexin_43	113,124	glucose	connexin 43	MESH:D005947	281193(Tax:9913)	Chemical	Gene	down-regulates|compound|START_ENTITY intercellular|nsubj|down-regulates intercellular|advcl|enhancing enhancing|dobj|degradation degradation|nmod|END_ENTITY	High glucose down-regulates intercellular communication in retinal endothelial cells by enhancing degradation of connexin_43 by a proteasome-dependent mechanism .
16675599	0	glucose	49,56	connexin_43	18,29	glucose	connexin 43	MESH:D005947	24392(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Downregulation of connexin_43 expression by high glucose induces senescence in glomerular mesangial cells .
19705457	0	glucose	16,23	connexin_43	147,158	glucose	connexin 43	MESH:D005947	24392(Tax:10116)	Chemical	Gene	Hypoxia|nmod|START_ENTITY reduces|nsubj|Hypoxia reduces|nmod|permeability permeability|nmod|hemichannels hemichannels|amod|END_ENTITY	Hypoxia in high glucose followed by reoxygenation in normal glucose reduces the viability of cortical astrocytes through increased permeability of connexin_43 hemichannels .
19705457	0	glucose	60,67	connexin_43	147,158	glucose	connexin 43	MESH:D005947	24392(Tax:10116)	Chemical	Gene	reoxygenation|nmod|START_ENTITY followed|nmod|reoxygenation glucose|acl|followed Hypoxia|nmod|glucose reduces|nsubj|Hypoxia reduces|nmod|permeability permeability|nmod|hemichannels hemichannels|amod|END_ENTITY	Hypoxia in high glucose followed by reoxygenation in normal glucose reduces the viability of cortical astrocytes through increased permeability of connexin_43 hemichannels .
26902399	0	glucose	5,12	connexin_43	89,100	glucose	connexin 43	MESH:D005947	2697	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|down-regulation down-regulation|nmod|END_ENTITY	High glucose induces dysfunction of airway epithelial barrier through down-regulation of connexin_43 .
12438692	0	glucose	72,79	corticotropin-releasing_factor	24,54	glucose	corticotropin-releasing factor	MESH:D005947	1392	Chemical	Gene	metabolism|compound|START_ENTITY increases|dobj|metabolism increases|nsubj|END_ENTITY	Intracerebroventricular corticotropin-releasing_factor increases limbic glucose metabolism and has social context-dependent behavioral effects in nonhuman primates .
15843869	0	glucose	79,86	corticotropin_releasing_factor	36,66	glucose	corticotropin releasing factor	MESH:D005947	81648(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY effects|nmod|metabolism effects|nmod|END_ENTITY	Time - and dose-dependent effects of corticotropin_releasing_factor on cerebral glucose metabolism in rats .
11132246	0	glucose	5,12	cyclooxygenase-2	39,55	glucose	cyclooxygenase-2	MESH:D005947	29527(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	High glucose enhances IL-1beta-induced cyclooxygenase-2 expression in rat vascular smooth muscle cells .
11230365	0	glucose	10,17	cyclooxygenase-2	68,84	glucose	cyclooxygenase-2	MESH:D005947	442942(Tax:9615)	Chemical	Gene	infusion|compound|START_ENTITY increases|nsubj|infusion increases|nmod|dogs dogs|nmod|inhibition inhibition|amod|END_ENTITY	Long-term glucose infusion increases arterial pressure in dogs with cyclooxygenase-2 inhibition .
12600916	0	glucose	5,12	cyclooxygenase-2	36,52	glucose	cyclooxygenase-2	MESH:D005947	5743	Chemical	Gene	causes|nsubj|START_ENTITY causes|dobj|upregulation upregulation|nmod|profile profile|amod|END_ENTITY	High glucose causes upregulation of cyclooxygenase-2 and alters prostanoid profile in human endothelial cells : role of protein kinase C and reactive oxygen species .
15653566	0	glucose	5,12	cyclooxygenase-2	100,116	glucose	cyclooxygenase-2	MESH:D005947	5743	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|pathway pathway|amod|END_ENTITY	High glucose induces human endothelial cell apoptosis through a phosphoinositide_3-kinase-regulated cyclooxygenase-2 pathway .
16341840	0	glucose	86,93	cyclooxygenase-2	24,40	glucose	cyclooxygenase-2	MESH:D005947	5743	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|expression expression|nmod|END_ENTITY	Increased expression of cyclooxygenase-2 in human pancreatic islets treated with high glucose or ligands of the advanced_glycation_endproduct-specific_receptor -LRB- AGER -RRB- , and in islets from diabetic mice .
17098211	0	glucose	48,55	cyclooxygenase-2	10,26	glucose	cyclooxygenase-2	MESH:D005947	5743	Chemical	Gene	transport|compound|START_ENTITY stimulate|dobj|transport stimulate|nsubj|inhibitors inhibitors|amod|END_ENTITY	Selective cyclooxygenase-2 inhibitors stimulate glucose transport in L6 myotubes in a protein kinase Cdelta-dependent manner .
19950211	0	glucose	5,12	cyclooxygenase-2	37,53	glucose	cyclooxygenase-2	MESH:D005947	19225(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|stress stress|amod|END_ENTITY	High glucose increases expression of cyclooxygenase-2 , increases oxidative stress and decreases the generation of nitric_oxide in mouse microvessel endothelial cells .
10966485	0	glucose	17,24	decorin	4,11	glucose	decorin	MESH:D005947	1634	Chemical	Gene	response|compound|START_ENTITY response|amod|END_ENTITY	The decorin high glucose response element and mechanism of its activation in human mesangial cells .
10094118	0	glucose	9,16	dipeptidyl_peptidase_IV	52,75	glucose	dipeptidyl peptidase IV	MESH:D005947	25253(Tax:10116)	Chemical	Gene	tolerance|compound|START_ENTITY treated|nsubj|tolerance treated|nmod|Ile-thiazolidide Ile-thiazolidide|amod|END_ENTITY	Improved glucose tolerance in rats treated with the dipeptidyl_peptidase_IV -LRB- CD26 -RRB- inhibitor Ile-thiazolidide .
10980284	0	glucose	9,16	dipeptidyl_peptidase_IV	66,89	glucose	dipeptidyl peptidase IV	MESH:D005947	13482(Tax:10090)	Chemical	Gene	tolerance|compound|START_ENTITY tolerance|nmod|END_ENTITY	Improved glucose tolerance and insulin secretion by inhibition of dipeptidyl_peptidase_IV in mice .
11980629	0	glucose	57,64	dipeptidyl_peptidase_IV	24,47	glucose	dipeptidyl peptidase IV	MESH:D005947	13482(Tax:10090)	Chemical	Gene	tolerance|compound|START_ENTITY improves|dobj|tolerance improves|nsubj|inhibition inhibition|nmod|END_ENTITY	Long-term inhibition of dipeptidyl_peptidase_IV improves glucose tolerance and preserves islet function in mice .
15215655	0	glucose	92,99	dipeptidyl_peptidase_IV	38,61	glucose	dipeptidyl peptidase IV	MESH:D005947	25253(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY Effects|nmod|levels Effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Effects of combination treatment with dipeptidyl_peptidase_IV inhibitor and sulfonylurea on glucose levels in rats .
17093132	0	glucose	97,104	dipeptidyl_peptidase_IV	32,55	glucose	dipeptidyl peptidase IV	MESH:D005947	13482(Tax:10090)	Chemical	Gene	levels|compound|START_ENTITY secretagogue|nmod|levels secretagogue|nsubj|Effects Effects|nmod|combination combination|nmod|inhibitor inhibitor|amod|END_ENTITY	Effects of the combination of a dipeptidyl_peptidase_IV inhibitor and an insulin secretagogue on glucose and insulin levels in mice and rats .
17244786	0	glucose	73,80	dipeptidyl_peptidase_IV	4,27	glucose	dipeptidyl peptidase IV	MESH:D005947	1803	Chemical	Gene	production|compound|START_ENTITY endogenous|dobj|production endogenous|nsubj|suppresses suppresses|amod|END_ENTITY	The dipeptidyl_peptidase_IV inhibitor vildagliptin suppresses endogenous glucose production and enhances islet function after single-dose administration in type 2 diabetic patients .
23184939	0	glucose	64,71	dipeptidyl_peptidase_IV	31,54	glucose	dipeptidyl peptidase IV	MESH:D005947	25253(Tax:10116)	Chemical	Gene	tolerance|compound|START_ENTITY improves|dobj|tolerance improves|nsubj|antibody antibody|nmod|END_ENTITY	An inhibitory antibody against dipeptidyl_peptidase_IV improves glucose tolerance in vivo .
9703325	0	glucose	9,16	dipeptidyl_peptidase_IV	78,101	glucose	dipeptidyl peptidase IV	MESH:D005947	25253(Tax:10116)	Chemical	Gene	tolerance|compound|START_ENTITY fatty|nsubj|tolerance fatty|nmod|administration administration|nmod|isoleucine_thiazolidide isoleucine_thiazolidide|amod|END_ENTITY	Improved glucose tolerance in Zucker fatty rats by oral administration of the dipeptidyl_peptidase_IV inhibitor isoleucine_thiazolidide .
25398480	0	glucose	12,19	endoglin	53,61	glucose	endoglin	MESH:D005947	2022	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|compound|END_ENTITY	Oscillating glucose and constant high glucose induce endoglin expression in endothelial cells : the role of oxidative stress .
10678145	0	glucose	5,12	endothelin-1	44,56	glucose	endothelin-1	MESH:D005947	100009270(Tax:9986)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|cells cells|amod|END_ENTITY	High glucose enhances mitogenic response to endothelin-1 in rabbit vascular smooth muscle cells .
10909984	0	glucose	40,47	endothelin-1	13,25	glucose	endothelin-1	MESH:D005947	281137(Tax:9913)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Induction of endothelin-1 expression by glucose : an effect of protein_kinase_C activation .
10960723	0	glucose	101,108	endothelin-1	17,29	glucose	endothelin-1	MESH:D005947	1906	Chemical	Gene	metabolism|compound|START_ENTITY men|nmod|metabolism cyclic_guanosine_monophosphate|nmod|men cyclic_guanosine_monophosphate|nsubj|plasma plasma|amod|END_ENTITY	Increased plasma endothelin-1 and intraplatelet cyclic_guanosine_monophosphate in men with disturbed glucose metabolism .
11602570	0	glucose	65,72	endothelin-1	22,34	glucose	endothelin-1	MESH:D005947	1906	Chemical	Gene	transporters|compound|START_ENTITY signaling|nmod|transporters PYK2|parataxis|signaling PYK2|nmod|mediator mediator|nmod|END_ENTITY	PYK2 as a mediator of endothelin-1 / G_alpha_11 signaling to GLUT4 glucose transporters .
1446793	0	glucose	74,81	endothelin-1	27,39	glucose	endothelin-1	MESH:D005947	281137(Tax:9913)	Chemical	Gene	levels|compound|START_ENTITY actions|nmod|levels actions|nsubj|Induction Induction|nmod|resistance resistance|nmod|END_ENTITY	Induction of resistance to endothelin-1 's biochemical actions by elevated glucose levels in retinal pericytes .
1504747	0	glucose	11,18	endothelin-1	75,87	glucose	endothelin-1	MESH:D005947	24323(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY reductase|nsubj|Effects reductase|nmod|responses responses|nmod|END_ENTITY	Effects of glucose , insulin or aldose reductase inhibition on responses to endothelin-1 of aortic rings from streptozotocin-induced diabetic rats .
15115660	0	glucose	53,60	endothelin-1	22,34	glucose	endothelin-1	MESH:D005947	1906	Chemical	Gene	transport|compound|START_ENTITY effect|nmod|transport effect|nmod|END_ENTITY	Synergistic effect of endothelin-1 and cyclic_AMP on glucose transport in 3T3-L1 adipocytes .
15589339	0	glucose	31,38	endothelin-1	58,70	glucose	endothelin-1	MESH:D005947	24323(Tax:10116)	Chemical	Gene	monitoring|nmod|START_ENTITY monitoring|nmod|model model|amod|END_ENTITY	On-line monitoring of striatum glucose and lactate in the endothelin-1 rat model of transient focal cerebral_ischemia using microdialysis and flow-injection analysis with biosensors .
1988773	0	glucose	10,17	endothelin-1	48,60	glucose	endothelin-1	MESH:D005947	1906	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|release release|amod|END_ENTITY	Effect of glucose and insulin on immunoreactive endothelin-1 release from cultured porcine aortic endothelial cells .
20207830	0	glucose	14,21	endothelin-1	32,44	glucose	endothelin-1	MESH:D005947	1906	Chemical	Gene	Regulation|nmod|START_ENTITY uptake|nsubj|Regulation uptake|advcl|END_ENTITY	Regulation of glucose uptake by endothelin-1 in human skeletal muscle in vivo and in vitro .
22384254	0	glucose	34,41	endothelin-1	60,72	glucose	endothelin-1	MESH:D005947	24323(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY uptake|acl|induced induced|nmod|END_ENTITY	HIF-1 and c-Src mediate increased glucose uptake induced by endothelin-1 and connexin43 in astrocytes .
25571911	0	glucose	5,12	endothelin-1	36,48	glucose	endothelin-1	MESH:D005947	1906	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|release release|nmod|production production|amod|END_ENTITY	High glucose induces the release of endothelin-1 through the inhibition of hydrogen_sulfide production in HUVECs .
7938704	0	glucose	109,116	endothelin-1	54,66	glucose	endothelin-1	MESH:D005947	24323(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY involved|nmod|production involved|nsubj|Evidence Evidence|nmod|cleavage cleavage|nmod|END_ENTITY	Evidence for phosphoramidon-sensitive cleavage of big endothelin-1 involved in endothelin-stimulated hepatic glucose production .
8150228	0	glucose	132,139	endothelin-1	8,20	glucose	endothelin-1	MESH:D005947	281137(Tax:9913)	Chemical	Gene	medium|compound|START_ENTITY cultured|nmod|medium cultured|nsubj|contraction contraction|amod|END_ENTITY	Altered endothelin-1 induced contraction and second messenger generation in bovine retinal microvascular pericytes cultured in high glucose medium .
8156101	0	glucose	93,100	endothelin-1	15,27	glucose	endothelin-1	MESH:D005947	1906	Chemical	Gene	Stimulation|nmod|START_ENTITY Stimulation|nmod|production production|amod|END_ENTITY	Stimulation of endothelin-1 production by thrombin , but lack of interference by high ambient glucose in vitro .
9867075	0	glucose	62,69	endothelin-1	14,26	glucose	endothelin-1	MESH:D005947	24323(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY inhibits|dobj|uptake inhibits|nsubj|END_ENTITY	Evidence that endothelin-1 -LRB- ET-1 -RRB- inhibits insulin-stimulated glucose uptake in rat adipocytes mainly through ETA receptors .
9987073	0	glucose	5,12	endothelin-1	80,92	glucose	endothelin-1	MESH:D005947	24323(Tax:10116)	Chemical	Gene	alters|nsubj|START_ENTITY alters|nmod|END_ENTITY	High glucose alters the response of mesangial cell protein_kinase_C isoforms to endothelin-1 .
11078371	0	glucose	22,29	endothelin-A_receptor	55,76	glucose	endothelin-A receptor	MESH:D005947	24326(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|activation activation|nmod|END_ENTITY	Endothelin stimulates glucose uptake via activation of endothelin-A_receptor in neonatal rat cardiomyocytes .
16837808	0	glucose	62,69	epidermal_growth_factor	5,28	glucose	epidermal growth factor	MESH:D005947	25313(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY regulation|nmod|levels participate|nmod|regulation participate|nsubj|END_ENTITY	Does epidermal_growth_factor participate in the regulation of glucose , insulin and glucagon levels ?
20864423	0	glucose	17,24	epidermal_growth_factor	48,71	glucose	epidermal growth factor	MESH:D005947	1950	Chemical	Gene	infusion|compound|START_ENTITY maintains|nsubj|infusion maintains|dobj|levels levels|compound|END_ENTITY	Early enteral 5 % glucose infusion maintains the epidermal_growth_factor levels in the jejunal flap used for pharyngo-oesophageal reconstruction .
2380179	0	glucose	51,58	epidermal_growth_factor	24,47	glucose	epidermal growth factor	MESH:D005947	1950	Chemical	Gene	metabolism|compound|START_ENTITY Toxicity|nmod|metabolism Toxicity|nmod|END_ENTITY	Toxicity and effects of epidermal_growth_factor on glucose metabolism of MDA-468 human breast_cancer cells .
8308572	0	glucose	8,15	epidermal_growth_factor	42,65	glucose	epidermal growth factor	MESH:D005947	13645(Tax:10090)	Chemical	Gene	absorption|compound|START_ENTITY enhanced|nsubjpass|absorption enhanced|nmod|END_ENTITY	Jejunal glucose absorption is enhanced by epidermal_growth_factor in mice .
8420953	0	glucose	26,33	epidermal_growth_factor	47,70	glucose	epidermal growth factor	MESH:D005947	25313(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY transport|nsubj|effect transport|nmod|END_ENTITY	Insulinomimetic effect on glucose transport by epidermal_growth_factor when combined with a major histocompatibility complex class I-derived peptide .
8843777	0	glucose	56,63	epidermal_growth_factor	18,41	glucose	epidermal growth factor	MESH:D005947	100008808(Tax:9986)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of luminal epidermal_growth_factor on enterocyte glucose and proline transport .
8866569	0	glucose	32,39	epidermal_growth_factor	95,118	glucose	epidermal growth factor	MESH:D005947	1950	Chemical	Gene	storage|compound|START_ENTITY induces|dobj|storage induces|nmod|adipocytes adipocytes|acl|overexpressing overexpressing|dobj|receptors receptors|compound|END_ENTITY	Epidermal_growth_factor induces glucose storage in transgenic 3T3-L1 adipocytes overexpressing epidermal_growth_factor receptors .
24004644	0	glucose	72,79	epithelial_growth_factor	97,121	glucose	epithelial growth factor	MESH:D005947	1950	Chemical	Gene	START_ENTITY|nmod|secretion secretion|nmod|END_ENTITY	Mesenchymal stem cells protect podocytes from apoptosis induced by high glucose via secretion of epithelial_growth_factor .
15563957	0	glucose	71,78	erythropoietin	10,24	glucose	erythropoietin	MESH:D005947	2056	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Effect Effect|nmod|END_ENTITY	Effect of erythropoietin on endothelial cell apoptosis induced by high glucose .
16804549	0	glucose	50,57	erythropoietin	76,90	glucose	erythropoietin	MESH:D005947	13856(Tax:10090)	Chemical	Gene	rate|compound|START_ENTITY elevated|dobj|rate elevated|nmod|transgenic_mice transgenic_mice|compound|END_ENTITY	Reduced cerebral_blood_flow but elevated cerebral glucose metabolic rate in erythropoietin overexpressing transgenic_mice with excessive erythrocytosis .
17691973	0	glucose	32,39	erythropoietin	60,74	glucose	erythropoietin	MESH:D005947	2056	Chemical	Gene	Vascular_injury|nmod|START_ENTITY mitigated|nsubjpass|Vascular_injury mitigated|nmod|END_ENTITY	Vascular_injury during elevated glucose can be mitigated by erythropoietin and Wnt signaling .
2199280	0	glucose	34,41	erythropoietin	60,74	glucose	erythropoietin	MESH:D005947	2056	Chemical	Gene	relationship|nmod|START_ENTITY control|nsubj|relationship control|dobj|END_ENTITY	Direct relationship of antepartum glucose control and fetal erythropoietin in human type 1 -LRB- insulin-dependent -RRB- diabetic_pregnancy .
21998614	0	glucose	5,12	erythropoietin	42,56	glucose	erythropoietin	MESH:D005947	24335(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|nmod|END_ENTITY	High glucose stimulates the expression of erythropoietin in rat glomerular epithelial cells .
22351476	0	glucose	29,36	erythropoietin	11,25	glucose	erythropoietin	MESH:D005947	24335(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY Effects|nmod|metabolism Effects|nmod|END_ENTITY	Effects of erythropoietin on glucose metabolism .
23885016	0	glucose	70,77	erythropoietin	31,45	glucose	erythropoietin	MESH:D005947	13856(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY alter|dobj|homeostasis alter|nsubj|knockdown knockdown|nmod|receptor receptor|compound|END_ENTITY	In vivo knockdown of adipocyte erythropoietin receptor does not alter glucose or energy homeostasis .
3675916	0	glucose	32,39	erythropoietin	10,24	glucose	erythropoietin	MESH:D005947	24335(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY Effect|nmod|transport Effect|nmod|END_ENTITY	Effect of erythropoietin on the glucose transport of rat erythrocytes and bone marrow cells .
7882604	0	glucose	29,36	erythropoietin	11,25	glucose	erythropoietin	MESH:D005947	2056	Chemical	Gene	tolerance|compound|START_ENTITY Effects|nmod|tolerance Effects|nmod|END_ENTITY	Effects of erythropoietin on glucose tolerance in hemodialysis patients .
8739283	0	glucose	44,51	erythropoietin	26,40	glucose	erythropoietin	MESH:D005947	2056	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	Early and late effects of erythropoietin on glucose metabolism in maintenance hemodialysis patients .
20220132	0	glucose	169,176	extracellular_signal-regulated_kinase	55,92	glucose	extracellular signal-regulated kinase	MESH:D005947	5594	Chemical	Gene	deprivation_in_HCT116_carcinoma|compound|START_ENTITY inducing|nmod|deprivation_in_HCT116_carcinoma antagonizes|advcl|inducing antagonizes|dobj|activation activation|amod|END_ENTITY	AMP-activated protein kinase antagonizes pro-apoptotic extracellular_signal-regulated_kinase activation by inducing dual-specificity protein phosphatases in response to glucose deprivation_in_HCT116_carcinoma .
24438607	0	glucose	101,108	farnesoid_X_receptor	43,63	glucose	farnesoid X receptor	MESH:D005947	60351(Tax:10116)	Chemical	Gene	homeostasis|compound|START_ENTITY Effect|nmod|homeostasis Effect|nmod|END_ENTITY	Effect of simvastatin on the expression of farnesoid_X_receptor in diabetic animal models of altered glucose homeostasis .
7601115	0	glucose	52,59	fatty-acid-synthase	13,32	glucose	fatty-acid-synthase	MESH:D005947	50671(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Induction of fatty-acid-synthase gene expression by glucose in primary culture of rat hepatocytes .
16840537	0	glucose	85,92	fibroblast_growth_factor-2	9,35	glucose	fibroblast growth factor-2	MESH:D005947	14173(Tax:10090)	Chemical	Gene	treatment|compound|START_ENTITY vitro|nmod|treatment produced|advcl|vitro produced|nsubjpass|END_ENTITY	Glycated fibroblast_growth_factor-2 is quickly produced in vitro upon low-millimolar glucose treatment and detected in vivo in diabetic mice .
22617565	0	glucose	54,61	fibroblast_growth_factor_19	8,35	glucose	fibroblast growth factor 19	MESH:D005947	14170(Tax:10090)	Chemical	Gene	control|nmod|START_ENTITY END_ENTITY|nmod|control	Role of fibroblast_growth_factor_19 in the control of glucose homeostasis .
8336711	0	glucose	48,55	gadd153	37,44	glucose	gadd153	MESH:D005947	1649	Chemical	Gene	deprivation|compound|START_ENTITY END_ENTITY|nmod|deprivation	Regulation of the C/EBP-related gene gadd153 by glucose deprivation .
7029674	0	glucose	77,84	gastric-inhibitory_polypeptide	23,53	glucose	gastric-inhibitory polypeptide	MESH:D005947	2695	Chemical	Gene	ingestion|compound|START_ENTITY END_ENTITY|nmod|ingestion	The response of plasma gastric-inhibitory_polypeptide -LRB- GIP -RRB- to slow and fast glucose ingestion in Billroth II resected patients and normal controls .
24330966	0	glucose	129,136	gastric_inhibitory_polypeptide	60,90	glucose	gastric inhibitory polypeptide	MESH:D005947	609020(Tax:9615)	Chemical	Gene	dogs|compound|START_ENTITY glucose|nmod|dogs glucose|amod|END_ENTITY	-LSB- The effects of gastric bypass procedures on blood glucose , gastric_inhibitory_polypeptide and glucagon-like_peptide-1 of normal glucose tolerance dogs -RSB- .
2648629	0	glucose	50,57	gastric_inhibitory_polypeptide	8,38	glucose	gastric inhibitory polypeptide	MESH:D005947	609020(Tax:9615)	Chemical	Gene	metabolism|compound|START_ENTITY Role|nmod|metabolism Role|nmod|END_ENTITY	Role of gastric_inhibitory_polypeptide in altered glucose metabolism after removal of the jejunum in dogs .
2668324	0	glucose	102,109	gastric_inhibitory_polypeptide	45,75	glucose	gastric inhibitory polypeptide	MESH:D005947	2695	Chemical	Gene	interactions|nmod|START_ENTITY properties|dep|interactions properties|nmod|END_ENTITY	Insulinotropic properties of synthetic human gastric_inhibitory_polypeptide in man : interactions with glucose , phenylalanine , and cholecystokinin-8 .
3076052	0	glucose	45,52	gastric_inhibitory_polypeptide	11,41	glucose	gastric inhibitory polypeptide	MESH:D005947	25040(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY Effects|nmod|metabolism Effects|nmod|END_ENTITY	Effects of gastric_inhibitory_polypeptide on glucose and lipid metabolism of isolated rat adipocytes .
6753107	0	glucose	82,89	gastric_inhibitory_polypeptide	11,41	glucose	gastric inhibitory polypeptide	MESH:D005947	2695	Chemical	Gene	intrajejunal|dobj|START_ENTITY Release|acl|intrajejunal Release|nmod|END_ENTITY	Release of gastric_inhibitory_polypeptide and insulin in response to intrajejunal glucose in duodenal ulcer patients before and after truncal vagotomy .
7042057	0	glucose	64,71	gastric_inhibitory_polypeptide	15,45	glucose	gastric inhibitory polypeptide	MESH:D005947	25040(Tax:10116)	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of gastric_inhibitory_polypeptide and arginine with glucose in the perfused pancreas of rats treated with triiodothyronine .
7178831	0	glucose	126,133	gastric_inhibitory_polypeptide	45,75	glucose	gastric inhibitory polypeptide	MESH:D005947	2695	Chemical	Gene	intraduodenally|compound|START_ENTITY amounts|nmod|intraduodenally increase|nmod|amounts increase|nmod|concentrations concentrations|nmod|END_ENTITY	Dose-dependent increase in concentrations of gastric_inhibitory_polypeptide and pancreatic_polypeptide after small amounts of glucose intraduodenally in man .
7250066	0	glucose	60,67	gastric_inhibitory_polypeptide	18,48	glucose	gastric inhibitory polypeptide	MESH:D005947	2695	Chemical	Gene	ingestion|compound|START_ENTITY induced|nmod|ingestion induced|nsubj|Hypersecretion Hypersecretion|nmod|END_ENTITY	Hypersecretion of gastric_inhibitory_polypeptide induced by glucose ingestion in diabetes_mellitus .
9078536	0	glucose	32,39	gastric_inhibitory_polypeptide	74,104	glucose	gastric inhibitory polypeptide	MESH:D005947	2695	Chemical	Gene	response|nmod|START_ENTITY associated|nsubjpass|response associated|nmod|stimulation stimulation|nmod|END_ENTITY	Acute incretin response to oral glucose is associated with stimulation of gastric_inhibitory_polypeptide , not glucagon-like peptide in young subjects .
11259736	0	glucose	15,22	gastrin	40,47	glucose	gastrin	MESH:D005947	2520	Chemical	Gene	Effect|nmod|START_ENTITY Effect|acl|loading loading|nmod|level level|compound|END_ENTITY	Effect of oral glucose loading on serum gastrin level in pregnant and non-pregnant women .
11932320	0	glucose	150,157	gastrin	79,86	glucose	gastrin	MESH:D005947	2520	Chemical	Gene	comparison|nmod|START_ENTITY comparison|nmod|cholecystokinin cholecystokinin|dep|END_ENTITY	A comparison of the effects of pegvisomant and octreotide on glucose , insulin , gastrin , cholecystokinin , and pancreatic_polypeptide responses to oral glucose and a standard mixed meal .
11932320	0	glucose	61,68	gastrin	79,86	glucose	gastrin	MESH:D005947	2520	Chemical	Gene	cholecystokinin|compound|START_ENTITY cholecystokinin|dep|END_ENTITY	A comparison of the effects of pegvisomant and octreotide on glucose , insulin , gastrin , cholecystokinin , and pancreatic_polypeptide responses to oral glucose and a standard mixed meal .
1467997	0	glucose	82,89	gastrin	43,50	glucose	gastrin	MESH:D005947	25320(Tax:10116)	Chemical	Gene	injection|compound|START_ENTITY suppressed|nmod|injection suppressed|nsubjpass|secretion secretion|acl|induced induced|nmod|END_ENTITY	Enhanced gastric acid secretion induced by gastrin can be suppressed partially by glucose injection into the medullary nuclei in rats .
1675778	0	glucose	14,21	gastrin	53,60	glucose	gastrin	MESH:D005947	25320(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|acl|induced induced|dobj|immunoreactivity immunoreactivity|compound|END_ENTITY	The effect of glucose and insulin on vagally induced gastrin , bombesin-like immunoreactivity and somatostatin secretion from the perfused rat stomach .
1989738	0	glucose	24,31	gastrin	6,13	glucose	gastrin	MESH:D005947	2520	Chemical	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Serum gastrin and blood glucose levels during halothane-nitrous_oxide anaesthesia and strabismus surgery in children .
6474088	0	glucose	24,31	gastrin	6,13	glucose	gastrin	MESH:D005947	2520	Chemical	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Serum gastrin and blood glucose levels in gastroplasty for morbid obesity .
7034159	0	glucose	81,88	gastrin	38,45	glucose	gastrin	MESH:D005947	100685087	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|2-sympathomimetic 2-sympathomimetic|nmod|release release|compound|END_ENTITY	Effect of a beta 2-sympathomimetic on gastrin release , acid secretion , and blood glucose during basal conditions and in response to insulin , 2-deoxy-D-glucose , and feeding in the dog .
8043025	0	glucose	72,79	gastrin	43,50	glucose	gastrin	MESH:D005947	25320(Tax:10116)	Chemical	Gene	suppressed|nmod|START_ENTITY suppressed|nsubjpass|secretion secretion|acl|induced induced|nmod|END_ENTITY	Enhanced gastric acid secretion induced by gastrin can be suppressed by glucose injected into the portal vein in rats .
8105515	0	glucose	116,123	gastrin	26,33	glucose	gastrin	MESH:D005947	2520	Chemical	Gene	load|compound|START_ENTITY diabetes|nmod|load forms|nmod|diabetes forms|nmod|END_ENTITY	Plasma molecular forms of gastrin , neurotensin and somatostatin in pregnancy and gestational diabetes after an oral glucose load or a mixed meal .
959755	0	glucose	59,66	gastrin	30,37	glucose	gastrin	MESH:D005947	2520	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of meal-stimulated gastrin secretion after oral glucose .
26358150	0	glucose	48,55	gastrin-releasing_peptide	19,44	glucose	gastrin-releasing peptide	MESH:D005947	171101(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY Effects|nmod|metabolism Effects|nmod|END_ENTITY	Effects of central gastrin-releasing_peptide on glucose metabolism .
17608064	0	glucose	8,15	gastrin_releasing_peptide	47,72	glucose	gastrin releasing peptide	MESH:D005947	2922	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|END_ENTITY	Reduced glucose uptake with markedly increased gastrin_releasing_peptide , osteopontine _ asbestos found in dark black areas of PET Scan of chest wall in patient with mesothelioma .
12429053	0	glucose	62,69	ghrelin	12,19	glucose	ghrelin	MESH:D005947	59301(Tax:10116)	Chemical	Gene	lowered|nmod|START_ENTITY lowered|nsubjpass|concentrations concentrations|compound|END_ENTITY	Circulating ghrelin concentrations are lowered by intravenous glucose or hyperinsulinemic euglycemic conditions in rodents .
17173080	0	glucose	50,57	ghrelin	11,18	glucose	ghrelin	MESH:D005947	59301(Tax:10116)	Chemical	Gene	metabolic_disorder|compound|START_ENTITY amelioration|nmod|metabolic_disorder level|nmod|amelioration level|compound|END_ENTITY	-LSB- Change in ghrelin level with the amelioration of glucose and lipid metabolic_disorder in OLETF rats -RSB- .
17673520	0	glucose	12,19	ghrelin	103,110	glucose	ghrelin	MESH:D005947	59301(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY has|nsubj|administration has|dobj|effects effects|nmod|END_ENTITY	Intravenous glucose administration in fasting rats has differential effects on acylated and unacylated ghrelin in the portal and systemic circulation : a comparison between portal and peripheral concentrations in anesthetized rats .
20438501	0	glucose	11,18	ghrelin	38,45	glucose	ghrelin	MESH:D005947	442996(Tax:9940)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of glucose and amino_acids on ghrelin secretion in sheep .
21150588	0	glucose	67,74	ghrelin	4,11	glucose	ghrelin	MESH:D005947	100861189	Chemical	Gene	metabolism|compound|START_ENTITY regulator|nmod|metabolism system|dep|regulator system|amod|END_ENTITY	The ghrelin O-acyltransferase-ghrelin system : a novel regulator of glucose metabolism .
21470317	0	glucose	84,91	ghrelin	25,32	glucose	ghrelin	MESH:D005947	58991(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY regulation|nmod|homeostasis role|nmod|regulation plays|dobj|role plays|nsubj|GPR39 GPR39|appos|receptor receptor|nmod|family family|compound|END_ENTITY	GPR39 , a receptor of the ghrelin receptor family , plays a role in the regulation of glucose homeostasis in a mouse model of early onset diet-induced obesity .
22338071	0	glucose	21,28	ghrelin	10,17	glucose	ghrelin	MESH:D005947	58991(Tax:10090)	Chemical	Gene	regulation|compound|START_ENTITY Effect|nmod|regulation Effect|nmod|END_ENTITY	Effect of ghrelin on glucose regulation in mice .
22669248	0	glucose	87,94	ghrelin	138,145	glucose	ghrelin	MESH:D005947	58991(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY has|nmod|homeostasis has|advcl|compared compared|nmod|ablation ablation|nmod|END_ENTITY	Ablation of ghrelin_receptor in leptin-deficient_ob / ob_mice has paradoxical effects on glucose homeostasis when compared with ablation of ghrelin in ob/ob mice .
23299855	0	glucose	72,79	ghrelin	9,16	glucose	ghrelin	MESH:D005947	58991(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY dysregulation|nmod|homeostasis prevent|dobj|dysregulation prevent|nsubj|analogs analogs|compound|END_ENTITY	Des-acyl ghrelin analogs prevent high-fat-diet-induced dysregulation of glucose homeostasis .
24714083	0	glucose	43,50	ghrelin	69,76	glucose	ghrelin	MESH:D005947	100861189	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|nmod|system system|compound|END_ENTITY	Mechanisms in endocrinology : regulation of glucose metabolism by the ghrelin system : multiple players and multiple actions .
25535832	9	glucose	1357,1364	ghrelin	1309,1316	glucose	ghrelin	MESH:D005947	58991(Tax:10090)	Chemical	Gene	increase|nmod|START_ENTITY had|dobj|increase had|nsubj|mice mice|compound|END_ENTITY	Icv ghrelin pf mice had an increase in plasma blood glucose during a pyruvate tolerance test relative to icv ghrelin ad-lib or aCSF mice .
26159083	0	glucose	51,58	ghrelin	26,33	glucose	ghrelin	MESH:D005947	59301(Tax:10116)	Chemical	Gene	regulates|dobj|START_ENTITY regulates|nsubj|administration administration|nmod|END_ENTITY	Chronic administration of ghrelin regulates plasma glucose and normalizes insulin levels following fasting hyperglycemia and hyperinsulinemia .
26159083	6	glucose	1266,1273	ghrelin	1233,1240	glucose	ghrelin	MESH:D005947	59301(Tax:10116)	Chemical	Gene	administration|nmod|START_ENTITY administration|compound|END_ENTITY	In addition , the comparison of the influence of ghrelin administration on plasma glucose and insulin levels on day 21 with those on the first day revealed that the chronic administration of ghrelin notably decreased plasma glucose and insulin levels relative to the acute ghrelin treatment .
26159083	6	glucose	1408,1415	ghrelin	1233,1240	glucose	ghrelin	MESH:D005947	59301(Tax:10116)	Chemical	Gene	decreased|dobj|START_ENTITY revealed|ccomp|decreased revealed|nsubj|comparison comparison|nmod|influence influence|nmod|administration administration|compound|END_ENTITY	In addition , the comparison of the influence of ghrelin administration on plasma glucose and insulin levels on day 21 with those on the first day revealed that the chronic administration of ghrelin notably decreased plasma glucose and insulin levels relative to the acute ghrelin treatment .
18840785	0	glucose	109,116	glucagon-like_Peptide_1	60,83	glucose	glucagon-like Peptide 1	MESH:D005947	403571(Tax:9615)	Chemical	Gene	START_ENTITY|amod|dipeptidyl_peptidase-4 dipeptidyl_peptidase-4|nmod|vildagliptin vildagliptin|nmod|increases increases|amod|END_ENTITY	Inhibition of dipeptidyl_peptidase-4 by vildagliptin during glucagon-like_Peptide_1 infusion increases liver glucose uptake in the conscious dog .
19727071	0	glucose	52,59	glucagon-like_peptide-1	20,43	glucose	glucagon-like peptide-1	MESH:D005947	2641	Chemical	Gene	homeostasis|compound|START_ENTITY affects|dobj|homeostasis affects|nsubj|END_ENTITY	Orally administered glucagon-like_peptide-1 affects glucose homeostasis following an oral glucose tolerance test in healthy male subjects .
8289665	0	glucose	71,78	glucagon-like_peptide-1	10,33	glucose	glucagon-like peptide-1	MESH:D005947	2641	Chemical	Gene	production|compound|START_ENTITY Effect|nmod|production Effect|nmod|END_ENTITY	Effect of glucagon-like_peptide-1 -LRB- proglucagon 78-107amide -RRB- on hepatic glucose production in healthy man .
19008308	0	glucose	58,65	glucagon-like_peptide-1_receptor	4,36	glucose	glucagon-like peptide-1 receptor	MESH:D005947	14652(Tax:10090)	Chemical	Gene	production|compound|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	The glucagon-like_peptide-1_receptor regulates endogenous glucose production and muscle glucose uptake independent of its incretin action .
22890715	0	glucose	14,21	glucagon-like_peptide-1_receptor	54,86	glucose	glucagon-like peptide-1 receptor	MESH:D005947	14652(Tax:10090)	Chemical	Gene	Regulation|nmod|START_ENTITY kinetics|nsubj|Regulation kinetics|nmod|END_ENTITY	Regulation of glucose kinetics during exercise by the glucagon-like_peptide-1_receptor .
24176797	0	glucose	60,67	glucagon-like_peptide-1_receptor	16,48	glucose	glucagon-like peptide-1 receptor	MESH:D005947	2740	Chemical	Gene	tolerance|compound|START_ENTITY agonist|nmod|tolerance agonist|amod|END_ENTITY	The effect of a glucagon-like_peptide-1_receptor agonist on glucose tolerance in women with previous_gestational_diabetes_mellitus : protocol for an investigator-initiated , randomised , placebo-controlled , double-blinded , parallel intervention trial .
24866833	0	glucose	127,134	glucagon-like_peptide-1_receptor	14,46	glucose	glucagon-like peptide-1 receptor	MESH:D005947	14652(Tax:10090)	Chemical	Gene	concentration|compound|START_ENTITY regulated|nmod|concentration regulated|nsubjpass|Expression Expression|nmod|receptor receptor|amod|END_ENTITY	Expression of glucagon-like_peptide-1_receptor and glucose - dependent insulinotropic polypeptide receptor is regulated by the glucose concentration in mouse osteoblastic MC3T3-E1 cells .
9220027	0	glucose	94,101	glucagon-like_peptide-1_receptor	18,50	glucose	glucagon-like peptide-1 receptor	MESH:D005947	2740	Chemical	Gene	responsiveness|compound|START_ENTITY enhances|dobj|responsiveness enhances|nsubj|Overexpression Overexpression|nmod|line line|amod|END_ENTITY	Overexpression of glucagon-like_peptide-1_receptor in an insulin-secreting cell line enhances glucose responsiveness .
9568699	0	glucose	46,53	glucagon-like_peptide-1_receptor	89,121	glucose	glucagon-like peptide-1 receptor	MESH:D005947	14652(Tax:10090)	Chemical	Gene	competence|compound|START_ENTITY preserved|dobj|competence preserved|nmod|disruption disruption|nmod|gene gene|amod|END_ENTITY	Mouse pancreatic beta-cells exhibit preserved glucose competence after disruption of the glucagon-like_peptide-1_receptor gene .
11193877	0	glucose	105,112	glucagon-like_peptide_1	127,150	glucose	glucagon-like peptide 1	MESH:D005947	24952(Tax:10116)	Chemical	Gene	amide|amod|START_ENTITY amide|amod|END_ENTITY	Cytosolic calcium handling in islets of normal Wistar and diabetic Goto Kakizaki rats in the presence of glucose and truncated glucagon-like_peptide_1 -LRB- 7-36 -RRB- amide .
12788879	0	glucose	17,24	glucagon-like_peptide_1	114,137	glucose	glucagon-like peptide 1	MESH:D005947	2641	Chemical	Gene	concentrations|compound|START_ENTITY Normalization|nmod|concentrations Normalization|acl|emptying emptying|nmod|END_ENTITY	Normalization of glucose concentrations and deceleration of gastric emptying after solid meals during intravenous glucagon-like_peptide_1 in patients with type 2 diabetes .
12806222	0	glucose	179,186	glucagon-like_peptide_1	83,106	glucose	glucagon-like peptide 1	MESH:D005947	2641	Chemical	Gene	metabolism|compound|START_ENTITY hormones|nmod|metabolism hormones|amod|END_ENTITY	Enteroinsular signaling : perspectives on the role of the gastrointestinal hormones glucagon-like_peptide_1 and glucose-dependent_insulinotropic_polypeptide in normal and abnormal glucose metabolism .
14759561	0	glucose	6,13	glucagon-like_peptide_1	129,152	glucose	glucagon-like peptide 1	MESH:D005947	2641	Chemical	Gene	control|nsubj|START_ENTITY control|xcomp|receiving receiving|dobj|infusion infusion|acl|using using|xcomp|END_ENTITY	Blood glucose control in healthy subject and patients receiving intravenous glucose infusion or total parenteral nutrition using glucagon-like_peptide_1 .
14759561	0	glucose	76,83	glucagon-like_peptide_1	129,152	glucose	glucagon-like peptide 1	MESH:D005947	2641	Chemical	Gene	infusion|compound|START_ENTITY infusion|acl|using using|xcomp|END_ENTITY	Blood glucose control in healthy subject and patients receiving intravenous glucose infusion or total parenteral nutrition using glucagon-like_peptide_1 .
15090972	0	glucose	53,60	glucagon-like_peptide_1	12,35	glucose	glucagon-like peptide 1	MESH:D005947	2641	Chemical	Gene	normalizes|dobj|START_ENTITY normalizes|nsubj|Intravenous Intravenous|amod|END_ENTITY	Intravenous glucagon-like_peptide_1 normalizes blood glucose after major surgery in patients with type 2 diabetes .
15655716	0	glucose	50,57	glucagon-like_peptide_1	11,34	glucose	glucagon-like peptide 1	MESH:D005947	2641	Chemical	Gene	metabolism|compound|START_ENTITY Effects|nmod|metabolism Effects|nmod|END_ENTITY	Effects of glucagon-like_peptide_1 on the hepatic glucose metabolism .
17259389	0	glucose	36,43	glucagon-like_peptide_1	87,110	glucose	glucagon-like peptide 1	MESH:D005947	24952(Tax:10116)	Chemical	Gene	dependence|compound|START_ENTITY dependence|nmod|effect effect|nmod|END_ENTITY	Sulfonylurea compounds uncouple the glucose dependence of the insulinotropic effect of glucagon-like_peptide_1 .
17609256	0	glucose	50,57	glucagon-like_peptide_1	87,110	glucose	glucagon-like peptide 1	MESH:D005947	2641	Chemical	Gene	ingestion|compound|START_ENTITY clearance|nmod|ingestion Reduction|nmod|clearance mediated|nsubjpass|Reduction mediated|advcl|END_ENTITY	Reduction of hepatic insulin clearance after oral glucose ingestion is not mediated by glucagon-like_peptide_1 or gastric_inhibitory_polypeptide in humans .
18511515	0	glucose	74,81	glucagon-like_peptide_1	33,56	glucose	glucagon-like peptide 1	MESH:D005947	2641	Chemical	Gene	homeostasis|compound|START_ENTITY improves|dobj|homeostasis improves|nsubj|Liraglutide Liraglutide|appos|analog analog|amod|END_ENTITY	Liraglutide , a long-acting human glucagon-like_peptide_1 analog , improves glucose homeostasis in marginal mass islet transplantation in mice .
18827000	0	glucose	101,108	glucagon-like_peptide_1	71,94	glucose	glucagon-like peptide 1	MESH:D005947	2641	Chemical	Gene	ingestion|compound|START_ENTITY END_ENTITY|nmod|ingestion	Regulation of islet hormone release and gastric emptying by endogenous glucagon-like_peptide_1 after glucose ingestion .
19920800	0	glucose	39,46	glucagon-like_peptide_1	12,35	glucose	glucagon-like peptide 1	MESH:D005947	2641	Chemical	Gene	homeostasis|compound|START_ENTITY role|nmod|homeostasis role|nmod|END_ENTITY	The role of glucagon-like_peptide_1 in glucose homeostasis and in other aspects of human physiology .
21046358	0	glucose	104,111	glucagon-like_peptide_1	33,56	glucose	glucagon-like peptide 1	MESH:D005947	24952(Tax:10116)	Chemical	Gene	signalling|nmod|START_ENTITY signalling|amod|END_ENTITY	Adenylyl_cyclase_8 is central to glucagon-like_peptide_1 signalling and effects of chronically elevated glucose in rat and human pancreatic beta cells .
23487174	0	glucose	154,161	glucagon-like_peptide_1	23,46	glucose	glucagon-like peptide 1	MESH:D005947	14526(Tax:10090)	Chemical	Gene	absorption|nmod|START_ENTITY cotransporter_1|dep|absorption reducing|dobj|cotransporter_1 increases|advcl|reducing increases|dobj|END_ENTITY	LX4211 increases serum glucagon-like_peptide_1 and peptide_YY levels by reducing sodium/glucose _ cotransporter_1 -LRB- SGLT1 -RRB- - mediated absorption of intestinal glucose .
23911260	0	glucose	43,50	glucagon-like_peptide_1	119,142	glucose	glucagon-like peptide 1	MESH:D005947	2641	Chemical	Gene	LX4211|appos|START_ENTITY Effects|nmod|LX4211 cotransporters|nsubj|Effects cotransporters|dobj|inhibitor inhibitor|nmod|END_ENTITY	Effects of LX4211 , a dual sodium-dependent glucose cotransporters 1 and 2 inhibitor , on postprandial glucose , insulin , glucagon-like_peptide_1 , and peptide tyrosine_tyrosine in a dose-timing study in healthy subjects .
24089513	0	glucose	54,61	glucagon-like_peptide_1	27,50	glucose	glucagon-like peptide 1	MESH:D005947	2641	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	Contribution of endogenous glucagon-like_peptide_1 to glucose metabolism after Roux-en-Y gastric bypass .
8530635	0	glucose	47,54	glucagon-like_peptide_1	97,120	glucose	glucagon-like peptide 1	MESH:D005947	2641	Chemical	Gene	response|nmod|START_ENTITY Constitution|nmod|response Constitution|nmod|beta-cells beta-cells|nmod|END_ENTITY	Constitution of a biphasic insulin response to glucose in human fetal pancreatic beta-cells with glucagon-like_peptide_1 .
8650968	0	glucose	126,133	glucagon-like_peptide_1	11,34	glucose	glucagon-like peptide 1	MESH:D005947	2641	Chemical	Gene	Release|nmod|START_ENTITY Release|nmod|END_ENTITY	Release of glucagon-like_peptide_1 -LRB- GLP-1 -LSB- 7-36 amide -RSB- -RRB- , gastric inhibitory polypeptide -LRB- GIP -RRB- and insulin in response to oral glucose after upper and lower intestinal resections .
8866556	0	glucose	38,45	glucagon-like_peptide_1	71,94	glucose	glucagon-like peptide 1	MESH:D005947	2641	Chemical	Gene	START_ENTITY|nmod|infusion infusion|nmod|amide amide|amod|END_ENTITY	Normalization of insulin responses to glucose by overnight infusion of glucagon-like_peptide_1 -LRB- 7-36 -RRB- amide in patients with NIDDM .
8921824	0	glucose	174,181	glucagon-like_peptide_1	128,151	glucose	glucagon-like peptide 1	MESH:D005947	2641	Chemical	Gene	ingestion|compound|START_ENTITY secretion|nmod|ingestion secretion|amod|END_ENTITY	Gut incretin hormones in identical twins discordant for non-insulin-dependent_diabetes_mellitus -LRB- NIDDM -RRB- -- evidence for decreased glucagon-like_peptide_1 secretion during oral glucose ingestion in NIDDM twins .
7729605	0	glucose	8,15	glucagon-like_peptide_I	30,53	glucose	glucagon-like peptide I	MESH:D005947	171528(Tax:10116)	Chemical	Gene	dependence|compound|START_ENTITY dependence|nmod|END_ENTITY	Altered glucose dependence of glucagon-like_peptide_I -LRB- 7-36 -RRB- - induced insulin secretion from the Zucker -LRB- fa/fa -RRB- rat pancreas .
22198437	0	glucose	52,59	glucagon_receptor	4,21	glucose	glucagon receptor	MESH:D005947	24953(Tax:10116)	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|mRNA mRNA|compound|END_ENTITY	Rat glucagon_receptor mRNA is directly regulated by glucose through transactivation of the carbohydrate_response_element_binding_protein .
1009116	0	glucose	27,34	glucokinase	56,67	glucose	glucokinase	MESH:D005947	24385(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY note|nmod|role note|nmod|protection protection|nmod|END_ENTITY	A note on the dual role of glucose in the protection of glucokinase against inactivation .
10480597	0	glucose	54,61	glucokinase	26,37	glucose	glucokinase	MESH:D005947	2645	Chemical	Gene	complex|nmod|START_ENTITY END_ENTITY|nmod|complex	Structural model of human glucokinase in complex with glucose and ATP : implications for the mutants that cause hypo - and hyperglycemia .
10512368	0	glucose	75,82	glucokinase	20,31	glucose	glucokinase	MESH:D005947	24385(Tax:10116)	Chemical	Gene	lowering|nmod|START_ENTITY overexpression|dep|lowering overexpression|amod|END_ENTITY	Metabolic impact of glucokinase overexpression in liver : lowering of blood glucose in fed rats is accompanied by hyperlipidemia .
10677361	0	glucose	126,133	glucokinase	81,92	glucose	glucokinase	MESH:D005947	2645	Chemical	Gene	sites|compound|START_ENTITY evidence|nmod|sites Investigation|dep|evidence Investigation|nmod|mechanism mechanism|acl:relcl|cause cause|dobj|translocation translocation|nmod|END_ENTITY	Investigation of the mechanism by which glucose analogues cause translocation of glucokinase in hepatocytes : evidence for two glucose binding sites .
10677361	0	glucose	40,47	glucokinase	81,92	glucose	glucokinase	MESH:D005947	2645	Chemical	Gene	analogues|compound|START_ENTITY cause|nsubj|analogues cause|dobj|translocation translocation|nmod|END_ENTITY	Investigation of the mechanism by which glucose analogues cause translocation of glucokinase in hepatocytes : evidence for two glucose binding sites .
10679232	0	glucose	12,19	glucokinase	60,71	glucose	glucokinase	MESH:D005947	2645	Chemical	Gene	role|nmod|START_ENTITY role|nmod|regulation regulation|nmod|expression expression|amod|END_ENTITY	The role of glucose and its metabolism in the regulation of glucokinase expression in isolated human pancreatic islets .
10744755	0	glucose	57,64	glucokinase	38,49	glucose	glucokinase	MESH:D005947	2645	Chemical	Gene	mechanism|amod|START_ENTITY role|nmod|mechanism role|nmod|protein protein|nmod|END_ENTITY	The role of the regulatory protein of glucokinase in the glucose sensory mechanism of the hepatocyte .
10868935	0	glucose	142,149	glucokinase	38,49	glucose	glucokinase	MESH:D005947	2645	Chemical	Gene	affinity|nmod|START_ENTITY enzyme|nmod|affinity glucokinase|nmod|enzyme conversion|nmod|glucokinase Study|dep|conversion Study|nmod|properties properties|nmod|END_ENTITY	Study of the regulatory properties of glucokinase by site-directed mutagenesis : conversion of glucokinase to an enzyme with high affinity for glucose .
10868935	0	glucose	142,149	glucokinase	94,105	glucose	glucokinase	MESH:D005947	2645	Chemical	Gene	affinity|nmod|START_ENTITY enzyme|nmod|affinity END_ENTITY|nmod|enzyme	Study of the regulatory properties of glucokinase by site-directed mutagenesis : conversion of glucokinase to an enzyme with high affinity for glucose .
10868944	0	glucose	99,106	glucokinase	152,163	glucose	glucokinase	MESH:D005947	2645	Chemical	Gene	metabolism|compound|START_ENTITY regulate|dobj|metabolism Effects|acl|regulate Effects|dep|evidence evidence|nmod|defect defect|nmod|activity activity|compound|END_ENTITY	Effects of type 2 diabetes on the ability of insulin and glucose to regulate splanchnic and muscle glucose metabolism : evidence for a defect in hepatic glucokinase activity .
10913113	0	glucose	88,95	glucokinase	65,76	glucose	glucokinase	MESH:D005947	24385(Tax:10116)	Chemical	Gene	rate|compound|START_ENTITY increases|dobj|rate increases|nsubj|phosphatase phosphatase|acl|interacting interacting|nmod|END_ENTITY	A novel cytosolic dual specificity phosphatase , interacting with glucokinase , increases glucose phosphorylation rate .
11076949	0	glucose	95,102	glucokinase	49,60	glucose	glucokinase	MESH:D005947	2645	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nmod|effect	Analysis of the cooperativity of human beta-cell glucokinase through the stimulatory effect of glucose on fructose phosphorylation .
11456280	0	glucose	22,29	glucokinase	61,72	glucose	glucokinase	MESH:D005947	24385(Tax:10116)	Chemical	Gene	Regulation|nmod|START_ENTITY metabolism|nsubj|Regulation metabolism|nmod|translocation translocation|nmod|END_ENTITY	Regulation of hepatic glucose metabolism by translocation of glucokinase between the nucleus and the cytoplasm in hepatocytes .
11916951	0	glucose	69,76	glucokinase	22,33	glucose	glucokinase	MESH:D005947	2645	Chemical	Gene	homeostasis|compound|START_ENTITY implications|nmod|homeostasis mutation|dep|implications mutation|amod|END_ENTITY	The second activating glucokinase mutation -LRB- A456V -RRB- : implications for glucose homeostasis and diabetes therapy .
12101177	0	glucose	112,119	glucokinase	26,37	glucose	glucokinase	MESH:D005947	2645	Chemical	Gene	binding|nmod|START_ENTITY binding|nsubj|link link|nmod|END_ENTITY	A functional link between glucokinase binding to insulin granules and conformational alterations in response to glucose and insulin .
12383517	0	glucose	115,122	glucokinase	32,43	glucose	glucokinase	MESH:D005947	850317(Tax:4932)	Chemical	Gene	repression|compound|START_ENTITY effects|nmod|repression Cloning|dep|effects Cloning|nmod|Hansenula_polymorpha Hansenula_polymorpha|amod|END_ENTITY	Cloning and characterization of glucokinase from a methylotrophic yeast Hansenula_polymorpha : different effects on glucose repression in H. _ polymorpha and Saccharomyces_cerevisiae .
12527145	0	glucose	84,91	glucokinase	62,73	glucose	glucokinase	MESH:D005947	100135866(Tax:8022)	Chemical	Gene	metabolism|dep|START_ENTITY END_ENTITY|dobj|metabolism	Muscle insulin binding and plasma levels in relation to liver glucokinase activity , glucose metabolism and dietary carbohydrates in rainbow_trout .
12542844	0	glucose	18,25	glucokinase	73,84	glucose	glucokinase	MESH:D005947	103988(Tax:10090)	Chemical	Gene	uptake|nsubj|START_ENTITY uptake|nmod|cells cells|acl|expressing expressing|dobj|diabetic_hyperglycemia diabetic_hyperglycemia|amod|END_ENTITY	Glucose-regulated glucose uptake by transplanted muscle cells expressing glucokinase counteracts diabetic_hyperglycemia .
12750016	0	glucose	29,36	glucokinase	16,27	glucose	glucokinase	MESH:D005947	24385(Tax:10116)	Chemical	Gene	RNAs|dep|START_ENTITY RNAs|amod|END_ENTITY	Distribution of glucokinase , glucose transporter GLUT2 , sulfonylurea_receptor-1 , glucagon-like_peptide-1_receptor and neuropeptide_Y messenger RNAs in rat brain by quantitative real time RT-PCR .
14656711	0	glucose	72,79	glucokinase	31,42	glucose	glucokinase	MESH:D005947	24385(Tax:10116)	Chemical	Gene	infusion|compound|START_ENTITY response|nmod|infusion translocation|nmod|response translocation|nmod|END_ENTITY	Rapid translocation of hepatic glucokinase in response to intraduodenal glucose infusion and changes in plasma glucose and insulin in conscious rats .
14988235	0	glucose	26,33	glucokinase	69,80	glucose	glucokinase	MESH:D005947	2645	Chemical	Gene	metabolism|compound|START_ENTITY Stimulation|nmod|metabolism Stimulation|nmod|activators activators|compound|END_ENTITY	Stimulation of hepatocyte glucose metabolism by novel small molecule glucokinase activators .
15047617	0	glucose	112,119	glucokinase	90,101	glucose	glucokinase	MESH:D005947	24385(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY activates|dobj|phosphorylation activates|nsubj|Interaction Interaction|nmod|END_ENTITY	Interaction of 6-phosphofructo-2-kinase / fructose-2 ,6 - bisphosphatase -LRB- PFK-2 / FBPase-2 -RRB- with glucokinase activates glucose phosphorylation and glucose metabolism in insulin-producing cells .
15677518	0	glucose	47,54	glucokinase	114,125	glucose	glucokinase	MESH:D005947	2645	Chemical	Gene	START_ENTITY|nmod|promoter promoter|nmod|gene gene|amod|END_ENTITY	Genetic regulation of birth weight and fasting glucose by a common polymorphism in the islet cell promoter of the glucokinase gene .
1612193	0	glucose	11,18	glucokinase	32,43	glucose	glucokinase	MESH:D005947	2645	Chemical	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	Concordant glucose induction of glucokinase , glucose usage , and glucose-stimulated insulin release in pancreatic islets maintained in organ culture .
16123348	0	glucose	25,32	glucokinase	143,154	glucose	glucokinase	MESH:D005947	103988(Tax:10090)	Chemical	Gene	Exposure|nmod|START_ENTITY induces|nsubj|Exposure induces|nmod|interaction interaction|dep|downregulation downregulation|nmod|END_ENTITY	Exposure to chronic high glucose induces beta-cell apoptosis through decreased interaction of glucokinase with mitochondria : downregulation of glucokinase in pancreatic beta-cells .
16123348	0	glucose	25,32	glucokinase	94,105	glucose	glucokinase	MESH:D005947	103988(Tax:10090)	Chemical	Gene	Exposure|nmod|START_ENTITY induces|nsubj|Exposure induces|nmod|interaction interaction|nmod|END_ENTITY	Exposure to chronic high glucose induces beta-cell apoptosis through decreased interaction of glucokinase with mitochondria : downregulation of glucokinase in pancreatic beta-cells .
16403021	0	glucose	98,105	glucokinase	60,71	glucose	glucokinase	MESH:D005947	2645	Chemical	Gene	mediating|nmod|START_ENTITY mediating|dobj|effects effects|nmod|overexpression overexpression|amod|END_ENTITY	The role of glucose_6-phosphate in mediating the effects of glucokinase overexpression on hepatic glucose metabolism .
16567505	0	glucose	85,92	glucokinase	166,177	glucose	glucokinase	MESH:D005947	24385(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY inhibit|dobj|phosphorylation inhibit|nmod|effect effect|nmod|translocation translocation|amod|END_ENTITY	5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside and metformin inhibit hepatic glucose phosphorylation by an AMP-activated_protein_kinase-independent effect on glucokinase translocation .
16804059	0	glucose	2,9	glucokinase	26,37	glucose	glucokinase	MESH:D005947	24385(Tax:10116)	Chemical	Gene	role|compound|START_ENTITY role|nmod|END_ENTITY	A glucose sensor role for glucokinase in anterior pituitary cells .
17267763	0	glucose	75,82	glucokinase	15,26	glucose	glucokinase	MESH:D005947	103988(Tax:10090)	Chemical	Gene	disposal|compound|START_ENTITY normalizes|dobj|disposal normalizes|nsubj|Restoration Restoration|nmod|expression expression|amod|END_ENTITY	Restoration of glucokinase expression in the liver normalizes postprandial glucose disposal in mice with hepatic_deficiency_of_PDK1 .
17374851	0	glucose	34,41	glucokinase	114,125	glucose	glucokinase	MESH:D005947	2645	Chemical	Gene	metabolism|compound|START_ENTITY coordination|nmod|metabolism coordination|dep|complex complex|amod|END_ENTITY	Molecular coordination of hepatic glucose metabolism by the 6-phosphofructo-2-kinase / fructose-2 ,6 - bisphosphatase : glucokinase complex .
17470517	0	glucose	11,18	glucokinase	34,45	glucose	glucokinase	MESH:D005947	24385(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|amod|END_ENTITY	Effects of glucose and insulin on glucokinase activity in rat hypothalamus .
18034843	0	glucose	27,34	glucokinase	70,81	glucose	glucokinase	MESH:D005947	103988(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY Effect|nmod|homeostasis Effect|nmod|mice mice|amod|END_ENTITY	Effect of high-fat diet on glucose homeostasis and gene expression in glucokinase knockout mice .
18411240	0	glucose	28,35	glucokinase	148,159	glucose	glucokinase	MESH:D005947	2645	Chemical	Gene	tolerance|compound|START_ENTITY follow-up|nmod|tolerance test-derived|nsubj|follow-up test-derived|nmod|mutations mutations|amod|END_ENTITY	Long-term follow-up of oral glucose tolerance test-derived glucose tolerance and insulin secretion and insulin sensitivity indexes in subjects with glucokinase mutations -LRB- MODY2 -RRB- .
18411240	0	glucose	59,66	glucokinase	148,159	glucose	glucokinase	MESH:D005947	2645	Chemical	Gene	tolerance|compound|START_ENTITY test-derived|dobj|tolerance test-derived|nmod|mutations mutations|amod|END_ENTITY	Long-term follow-up of oral glucose tolerance test-derived glucose tolerance and insulin secretion and insulin sensitivity indexes in subjects with glucokinase mutations -LRB- MODY2 -RRB- .
18508397	0	glucose	210,217	glucokinase	37,48	glucose	glucokinase	MESH:D005947	2645	Chemical	Gene	level|nmod|START_ENTITY fed|nmod|level juveniles|acl|fed Rearing|nsubj|juveniles Rearing|dep|enhances enhances|dobj|END_ENTITY	Rearing temperature enhances hepatic glucokinase but not glucose-6-phosphatase activities in European sea bass -LRB- Dicentrarchus labrax -RRB- and gilthead sea bream -LRB- Sparus aurata -RRB- juveniles fed with the same level of glucose .
18952838	0	glucose	98,105	glucokinase	23,34	glucose	glucokinase	MESH:D005947	24385(Tax:10116)	Chemical	Gene	corrects|dobj|START_ENTITY corrects|nsubj|Restoration Restoration|nmod|expression expression|compound|END_ENTITY	Restoration of hepatic glucokinase expression corrects hepatic_glucose_flux and normalizes plasma glucose in zucker_diabetic_fatty_rats .
19125755	0	glucose	48,55	glucokinase	78,89	glucose	glucokinase	MESH:D005947	2645	Chemical	Gene	START_ENTITY|xcomp|due due|nmod|mutation mutation|amod|END_ENTITY	Pregnancy outcome in patients with raised blood glucose due to a heterozygous glucokinase gene mutation .
19267880	0	glucose	70,77	glucokinase	43,54	glucose	glucokinase	MESH:D005947	24385(Tax:10116)	Chemical	Gene	regulates|nmod|START_ENTITY regulates|dobj|transcription transcription|nmod|END_ENTITY	PREB regulates transcription of pancreatic glucokinase in response to glucose and cAMP .
19459610	0	glucose	20,27	glucokinase	63,74	glucose	glucokinase	MESH:D005947	2645	Chemical	Gene	activators|compound|START_ENTITY activators|nmod|END_ENTITY	Binding kinetics of glucose and allosteric activators to human glucokinase reveal multiple conformational states .
19617908	0	glucose	49,56	glucokinase	114,125	glucose	glucokinase	MESH:D005947	2645	Chemical	Gene	phosphorylation|compound|START_ENTITY determinant|nmod|phosphorylation determinant|dep|implication implication|nmod|mechanism mechanism|nmod|catalysis catalysis|amod|END_ENTITY	Lys169 of human glucokinase is a determinant for glucose phosphorylation : implication for the atomic mechanism of glucokinase catalysis .
19617908	0	glucose	49,56	glucokinase	16,27	glucose	glucokinase	MESH:D005947	2645	Chemical	Gene	phosphorylation|compound|START_ENTITY determinant|nmod|phosphorylation determinant|nsubj|Lys169 Lys169|nmod|END_ENTITY	Lys169 of human glucokinase is a determinant for glucose phosphorylation : implication for the atomic mechanism of glucokinase catalysis .
19643913	0	glucose	57,64	glucokinase	125,136	glucose	glucokinase	MESH:D005947	2645	Chemical	Gene	fasting|dobj|START_ENTITY associated|advcl|fasting GCKR|acl|associated variant|nmod|GCKR exerts|nsubj|variant exerts|nmod|activity activity|amod|END_ENTITY	The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver .
20465996	0	glucose	52,59	glucokinase	17,28	glucose	glucokinase	MESH:D005947	24385(Tax:10116)	Chemical	Gene	lowers|dobj|START_ENTITY lowers|nsubj|activator activator|compound|END_ENTITY	A small-molecule glucokinase activator lowers blood glucose in the sulfonylurea-desensitized rat .
20739378	0	glucose	70,77	glucokinase	33,44	glucose	glucokinase	MESH:D005947	2645	Chemical	Gene	lowers|dobj|START_ENTITY lowers|nsubj|Piragliatin Piragliatin|appos|activator activator|compound|END_ENTITY	Piragliatin -LRB- RO4389620 -RRB- , a novel glucokinase activator , lowers plasma glucose both in the postabsorptive state and after a glucose challenge in patients with type_2_diabetes_mellitus : a mechanistic study .
20828143	0	glucose	23,30	glucokinase	105,116	glucose	glucokinase	MESH:D005947	2645	Chemical	Gene	curves|compound|START_ENTITY analysis|nmod|curves reveals|nsubj|analysis reveals|dobj|model model|nmod|cooperativity cooperativity|nmod|END_ENTITY	Global fit analysis of glucose binding curves reveals a minimal model for kinetic cooperativity in human glucokinase .
20977462	0	glucose	33,40	glucokinase	140,151	glucose	glucokinase	MESH:D005947	2645	Chemical	Gene	levels|compound|START_ENTITY raising|dobj|levels raising|advcl|blocking blocking|dobj|translocation translocation|nmod|END_ENTITY	Curcumin prevents leptin raising glucose levels in hepatic stellate cells by blocking translocation of glucose_transporter-4 and increasing glucokinase .
2139493	0	glucose	88,95	glucokinase	38,49	glucose	glucokinase	MESH:D005947	24385(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY influence|nmod|concentration Control|dep|influence Control|nmod|glycolysis glycolysis|nmod|liver liver|nmod|END_ENTITY	Control of glycolysis in rat liver by glucokinase and phosphofructokinase : influence of glucose concentration .
21537389	0	glucose	66,73	glucokinase	22,33	glucose	glucokinase	MESH:D005947	2645	Chemical	Gene	associated|nsubjpass|START_ENTITY raises|ccomp|associated polymorphism|acl:relcl|raises polymorphism|nmod|gene gene|amod|END_ENTITY	A polymorphism in the glucokinase gene that raises plasma fasting glucose , rs1799884 , is associated with diabetes_mellitus and prostate_cancer : findings from a population-based , case-control study -LRB- the ProtecT study -RRB- .
22446163	0	glucose	69,76	glucokinase	21,32	glucose	glucokinase	MESH:D005947	2645	Chemical	Gene	influenced|nmod|START_ENTITY influenced|nsubj|stability stability|nmod|END_ENTITY	Thermal stability of glucokinase -LRB- GK -RRB- as influenced by the substrate glucose , an allosteric glucokinase activator drug -LRB- GKA -RRB- and the osmolytes glycerol and urea .
22446163	0	glucose	69,76	glucokinase	92,103	glucose	glucokinase	MESH:D005947	2645	Chemical	Gene	START_ENTITY|appos|drug drug|amod|END_ENTITY	Thermal stability of glucokinase -LRB- GK -RRB- as influenced by the substrate glucose , an allosteric glucokinase activator drug -LRB- GKA -RRB- and the osmolytes glycerol and urea .
2256915	0	glucose	23,30	glucokinase	77,88	glucose	glucokinase	MESH:D005947	2645	Chemical	Gene	utilization|compound|START_ENTITY preference|nmod|utilization loaded|nsubj|preference loaded|nmod|END_ENTITY	Anomeric preference of glucose utilization in human erythrocytes loaded with glucokinase .
23010558	0	glucose	69,76	glucokinase	4,15	glucose	glucokinase	MESH:D005947	2645	Chemical	Gene	decreases|dobj|START_ENTITY decreases|nsubj|AZD6370 AZD6370|amod|END_ENTITY	The glucokinase activator AZD6370 decreases fasting and postprandial glucose in type_2_diabetes_mellitus patients with effects influenced by dosing regimen and food .
23291412	0	glucose	48,55	glucokinase	98,109	glucose	glucokinase	MESH:D005947	103988(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY expression|nmod|metabolism expression|nmod|liver liver|nmod|mice mice|amod|END_ENTITY	Differential expression of genes and changes in glucose metabolism in the liver of liver-specific glucokinase gene knockout mice .
23816435	0	glucose	40,47	glucokinase	72,83	glucose	glucokinase	MESH:D005947	24385(Tax:10116)	Chemical	Gene	START_ENTITY|xcomp|lowering lowering|dobj|effects effects|nmod|LCZ960 LCZ960|amod|END_ENTITY	Hepatic glycogen cycling contributes to glucose lowering effects of the glucokinase activator LCZ960 .
24075984	0	glucose	13,20	glucokinase	34,45	glucose	glucokinase	MESH:D005947	2645	Chemical	Gene	utilization|compound|START_ENTITY Evolution|nmod|utilization Evolution|dep|END_ENTITY	Evolution of glucose utilization : glucokinase and glucokinase regulator protein .
24772484	0	glucose	91,98	glucokinase	8,19	glucose	glucokinase	MESH:D005947	2645	Chemical	Gene	gives|dobj|START_ENTITY gives|nsubj|treatment treatment|amod|END_ENTITY	Chronic glucokinase activator treatment at clinically translatable exposures gives durable glucose lowering in two animal models of type_2_diabetes .
24843498	0	glucose	77,84	glucokinase	52,63	glucose	glucokinase	MESH:D005947	103988(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY activator|nmod|metabolism activator|nsubj|Effect Effect|nmod|treatment treatment|nmod|END_ENTITY	Effect of long-term treatment with a small-molecule glucokinase activator on glucose metabolism , lipid profiles and hepatic function .
25200293	0	glucose	6,13	glucokinase	23,34	glucose	glucokinase	MESH:D005947	2645	Chemical	Gene	sensing|compound|START_ENTITY sensing|appos|control control|amod|END_ENTITY	Brain glucose sensing , glucokinase and neural control of metabolism and islet function .
26620281	0	glucose	56,63	glucokinase	90,101	glucose	glucokinase	MESH:D005947	103988(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY decreases|dobj|metabolism decreases|advcl|suppressing suppressing|dobj|activity activity|amod|END_ENTITY	Acetylation of glucokinase_regulatory_protein decreases glucose metabolism by suppressing glucokinase activity .
2972577	0	glucose	11,18	glucokinase	58,69	glucose	glucokinase	MESH:D005947	2645	Chemical	Gene	Control|nmod|START_ENTITY metabolism|nsubj|Control metabolism|advcl|END_ENTITY	Control of glucose metabolism in pancreatic beta-cells by glucokinase , hexokinase , and phosphofructokinase .
3530846	0	glucose	54,61	glucokinase	18,29	glucose	glucokinase	MESH:D005947	24385(Tax:10116)	Chemical	Gene	sensor|compound|START_ENTITY Identification|nmod|sensor Identification|nmod|END_ENTITY	Identification of glucokinase as an alloxan-sensitive glucose sensor of the pancreatic beta-cell .
3872098	0	glucose	89,96	glucokinase	22,33	glucose	glucokinase	MESH:D005947	24385(Tax:10116)	Chemical	Gene	respect|nmod|START_ENTITY behavior|nmod|respect loss|nmod|behavior Effect|dep|loss Effect|nmod|glycerol glycerol|nmod|activity activity|amod|END_ENTITY	Effect of glycerol on glucokinase activity : loss of cooperative behavior with respect to glucose .
5834248	0	glucose	50,57	glucokinase	12,23	glucose	glucokinase	MESH:D005947	24385(Tax:10116)	Chemical	Gene	phosphorylation|nmod|START_ENTITY role|nmod|phosphorylation role|nmod|END_ENTITY	The role of glucokinase in the phosphorylation of glucose by rat liver .
6089596	0	glucose	44,51	glucokinase	29,40	glucose	glucokinase	MESH:D005947	2645	Chemical	Gene	sensor|compound|START_ENTITY identifies|nmod|sensor identifies|dobj|END_ENTITY	Computer modeling identifies glucokinase as glucose sensor of pancreatic beta-cells .
6274313	0	glucose	22,29	glucokinase	62,73	glucose	glucokinase	MESH:D005947	24385(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|induction induction|nmod|END_ENTITY	The separate roles of glucose and insulin in the induction of glucokinase in hepatocytes isolated from neonatal rats .
6304052	0	glucose	18,25	glucokinase	37,48	glucose	glucokinase	MESH:D005947	24385(Tax:10116)	Chemical	Gene	Discrimination|nmod|START_ENTITY anomers|nsubj|Discrimination anomers|nmod|END_ENTITY	Discrimination of glucose anomers by glucokinase from liver_and_transplantable_insulinoma .
7487979	0	glucose	143,150	glucokinase	46,57	glucose	glucokinase	MESH:D005947	24385(Tax:10116)	Chemical	Gene	cytoplasm|nmod|START_ENTITY regulator|nmod|cytoplasm location|nmod|regulator location|nmod|regulatory_protein regulatory_protein|nmod|END_ENTITY	Nuclear location of the regulatory_protein of glucokinase in rat liver and translocation of the regulator to the cytoplasm in response to high glucose .
7553875	0	glucose	103,110	glucokinase	76,87	glucose	glucokinase	MESH:D005947	103988(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY maintaining|dobj|homeostasis reveal|advcl|maintaining reveal|dobj|requirement requirement|nmod|END_ENTITY	Transgenic knockouts reveal a critical requirement for pancreatic beta cell glucokinase in maintaining glucose homeostasis .
7556622	0	glucose	132,139	glucokinase	35,46	glucose	glucokinase	MESH:D005947	103988(Tax:10090)	Chemical	Gene	tolerance|compound|START_ENTITY alteration|nmod|tolerance Inhibition|dep|alteration Inhibition|nmod|END_ENTITY	Inhibition of pancreatic beta-cell glucokinase by antisense RNA expression in transgenic_mice : mouse_strain-dependent alteration of glucose tolerance .
7755556	0	glucose	11,18	glucokinase	60,71	glucose	glucokinase	MESH:D005947	24385(Tax:10116)	Chemical	Gene	refeeding|compound|START_ENTITY refeeding|nmod|expression expression|compound|END_ENTITY	Effects of glucose refeeding and glibenclamide treatment on glucokinase and GLUT2 gene expression in pancreatic B-cells and liver from rats .
7929837	0	glucose	22,29	glucokinase	80,91	glucose	glucokinase	MESH:D005947	24385(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Regulatory effects of glucose on the catalytic activity and cellular content of glucokinase in the pancreatic beta cell .
7945367	0	glucose	42,49	glucokinase	13,24	glucose	glucokinase	MESH:D005947	24385(Tax:10116)	Chemical	Gene	translocation|nmod|START_ENTITY translocation|nsubj|Evidence Evidence|nmod|END_ENTITY	Evidence for glucokinase translocation by glucose in rat hepatocytes .
8227065	0	glucose	93,100	glucokinase	8,19	glucose	glucokinase	MESH:D005947	24385(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Role of glucokinase and glucose-6-phosphatase in the acute and chronic regulation of hepatic glucose fluxes by insulin .
8280078	0	glucose	73,80	glucokinase	25,36	glucose	glucokinase	MESH:D005947	2645	Chemical	Gene	binding|nmod|START_ENTITY binding|nmod|END_ENTITY	Intracellular binding of glucokinase in hepatocytes and translocation by glucose , fructose and insulin .
8344989	0	glucose	28,35	glucokinase	53,64	glucose	glucokinase	MESH:D005947	2645	Chemical	Gene	Interaction|nmod|START_ENTITY transporter|nsubj|Interaction transporter|nmod|END_ENTITY	Interaction of facilitative glucose transporter with glucokinase and its modulation by ADP and glucose-6-phosphate .
8490562	0	glucose	50,57	glucokinase	27,38	glucose	glucokinase	MESH:D005947	24385(Tax:10116)	Chemical	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Differential regulation of glucokinase and GLUT-2 glucose transporter gene expression in pancreas and liver from neonatal and 16 day old rats .
8549869	1	glucose	83,90	glucokinase	71,82	glucose	glucokinase	MESH:D005947	2645	Chemical	Gene	paradigm|compound|START_ENTITY paradigm|amod|END_ENTITY	A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm .
8589800	3	glucose	655,662	glucokinase	642,653	glucose	glucokinase	MESH:D005947	24385(Tax:10116)	Chemical	Gene	substrate|compound|START_ENTITY END_ENTITY|appos|substrate	The addition of 3-O-methyl-GlcNAc to the assay system for glucokinase in rat liver extracts , which contain a high activity of glucokinase -LRB- glucose as substrate -RRB- relative to N-acetylglucosamine kinase -LRB- N-acetyl-D-glucosamine as substrate -RRB- , affected neither Km nor Vmax values of glucokinase .
8751724	0	glucose	68,75	glucokinase	35,46	glucose	glucokinase	MESH:D005947	103988(Tax:10090)	Chemical	Gene	utilization|compound|START_ENTITY limiting|nmod|utilization rate|acl|limiting rate|nsubj|Evidence Evidence|nmod|transgenic_mice transgenic_mice|acl:relcl|END_ENTITY	Evidence from transgenic_mice that glucokinase is rate limiting for glucose utilization in the liver .
8826967	0	glucose	112,119	glucokinase	40,51	glucose	glucokinase	MESH:D005947	24385(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY suppress|dobj|production impairs|xcomp|suppress impairs|nsubj|inhibition inhibition|nmod|END_ENTITY	Glucosamine-induced inhibition of liver glucokinase impairs the ability of hyperglycemia to suppress endogenous glucose production .
8878353	0	glucose	90,97	glucokinase	8,19	glucose	glucokinase	MESH:D005947	24385(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY regulation|nmod|production Role|nmod|regulation Role|nmod|phosphatase phosphatase|amod|END_ENTITY	Role of glucokinase and glucose-6 phosphatase in the nutritional regulation of endogenous glucose production .
9088772	0	glucose	154,161	glucokinase	77,88	glucose	glucokinase	MESH:D005947	2645	Chemical	Gene	response|nmod|START_ENTITY associated|nmod|response associated|nsubjpass|Homozygosity Homozygosity|nmod|polymorphism polymorphism|nmod|promoter promoter|nmod|gene gene|amod|END_ENTITY	Homozygosity for a common polymorphism in the islet-specific promoter of the glucokinase gene is associated with a reduced early insulin response to oral glucose in pregnant women .
9113996	0	glucose	14,21	glucokinase	90,101	glucose	glucokinase	MESH:D005947	2645	Chemical	Gene	responsiveness_of_insulinoma|compound|START_ENTITY Modulation|nmod|responsiveness_of_insulinoma beta-cells|nsubj|Modulation beta-cells|nmod|overexpression overexpression|nmod|END_ENTITY	Modulation of glucose responsiveness_of_insulinoma beta-cells by graded overexpression of glucokinase .
9177383	0	glucose	65,72	glucokinase	33,44	glucose	glucokinase	MESH:D005947	2645	Chemical	Gene	tolerance|compound|START_ENTITY END_ENTITY|nmod|tolerance	Studies of the impact of a liver glucokinase promoter variant on glucose tolerance and insulin sensitivity index .
9376178	0	glucose	149,156	glucokinase	13,24	glucose	glucokinase	MESH:D005947	24385(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY regulation|nmod|metabolism involvement|nmod|regulation Shuttling|dep|involvement Shuttling|nmod|END_ENTITY	Shuttling of glucokinase between the nucleus and the cytoplasm in primary cultures of rat hepatocytes : possible involvement in the regulation of the glucose metabolism .
9726226	0	glucose	134,141	glucokinase	14,25	glucose	glucokinase	MESH:D005947	2645	Chemical	Gene	disposal|compound|START_ENTITY increases|nmod|disposal confers|dobj|increases confers|nsubj|Expression Expression|nmod|END_ENTITY	Expression of glucokinase in cultured human muscle cells confers insulin-independent and glucose concentration-dependent increases in glucose disposal and storage .
9867845	0	glucose	30,37	glucokinase	15,26	glucose	glucokinase	MESH:D005947	103988(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY END_ENTITY|nmod|homeostasis	Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase .
10622744	0	glucose	13,20	glucokinase_regulatory_protein	60,90	glucose	glucokinase regulatory protein	MESH:D005947	2646	Chemical	Gene	Evidence|nmod|START_ENTITY Evidence|nmod|END_ENTITY	Evidence for glucose and sorbitol-induced nuclear export of glucokinase_regulatory_protein in hepatocytes .
23307301	0	glucose	99,106	glucokinase_regulatory_protein	15,45	glucose	glucokinase regulatory protein	MESH:D005947	2646	Chemical	Gene	polymorphism|nmod|START_ENTITY polymorphism|compound|END_ENTITY	Association of glucokinase_regulatory_protein polymorphism with type_2_diabetes and fasting plasma glucose : a meta-analysis .
20554486	4	glucose	716,723	glucose	686,693	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY levels|nmod|test levels|compound|END_ENTITY	PATIENTS AND METHODS : Total adiponectin and isoform distribution were measured in 54 biopsy-proven , non-diabetic nonalcoholic fatty liver_disease subjects , divided according to their fasting and 120-min glucose levels during an oral glucose tolerance test , as well as in 44 matched healthy controls .
2894176	3	glucose	500,507	glucose	465,472	glucose	insulin	MESH:D005947	3630	Chemical	Gene	responses|compound|START_ENTITY responses|compound|END_ENTITY	Depressed patients demonstrated significantly higher basal glucose levels , greater cumulative glucose responses after the GTT , and larger cumulative insulin responses after the GTT than control subjects .
11007790	0	glucose	5,12	glucose-6-phosphate_dehydrogenase	22,55	glucose	glucose-6-phosphate dehydrogenase	MESH:D005947	2539	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	High glucose inhibits glucose-6-phosphate_dehydrogenase via cAMP in aortic endothelial cells .
12930785	0	glucose	19,26	glucose-6-phosphate_dehydrogenase	140,173	glucose	glucose-6-phosphate dehydrogenase	MESH:D005947	24377(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY involvement|nmod|metabolism involvement|dep|role role|nmod|END_ENTITY	The involvement of glucose metabolism in the regulation of inducible_nitric_oxide_synthase gene expression in glial cells : possible role of glucose-6-phosphate_dehydrogenase and CCAAT/enhancing _ binding_protein .
20032314	0	glucose	5,12	glucose-6-phosphate_dehydrogenase	22,55	glucose	glucose-6-phosphate dehydrogenase	MESH:D005947	14380(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	High glucose inhibits glucose-6-phosphate_dehydrogenase , leading to increased oxidative stress and beta-cell apoptosis .
236572	0	glucose	17,24	glucose-6-phosphate_dehydrogenase	60,93	glucose	glucose-6-phosphate dehydrogenase	MESH:D005947	2539	Chemical	Gene	concentrations|compound|START_ENTITY Role|nmod|concentrations Role|nmod|hemolysis hemolysis|nmod|erythroycytes erythroycytes|amod|END_ENTITY	Role of elevated glucose concentrations in the hemolysis of glucose-6-phosphate_dehydrogenase deficient erythroycytes -LRB- 38474 -RRB- .
3218146	0	glucose	173,180	glucose-6-phosphate_dehydrogenase	51,84	glucose	glucose-6-phosphate dehydrogenase	MESH:D005947	2539	Chemical	Gene	-RSB-|compound|START_ENTITY rate|nmod|-RSB- superoxide|advcl|rate superoxide|nsubj|Changes Changes|amod|END_ENTITY	-LSB- Changes in glyceraldehydephosphate dehydrogenase , glucose-6-phosphate_dehydrogenase , superoxide dismutase , and catalase activity in erythrocytes depending upon the rate of glucose utilization -RSB- .
9279024	0	glucose	84,91	glucose-dependent_insulinotropic_polypeptide	10,54	glucose	glucose-dependent insulinotropic polypeptide	MESH:D005947	2695	Chemical	Gene	response|nmod|START_ENTITY Effect|nmod|response Effect|nmod|END_ENTITY	Effect of glucose-dependent_insulinotropic_polypeptide -LRB- GIP -RRB- on insulin response to glucose in acromegalics .
9782188	0	glucose	69,76	glucose-dependent_insulinotropic_polypeptide	10,54	glucose	glucose-dependent insulinotropic polypeptide	MESH:D005947	101113509	Chemical	Gene	utilization|compound|START_ENTITY Effect|nmod|utilization Effect|nmod|END_ENTITY	Effect of glucose-dependent_insulinotropic_polypeptide on whole-body glucose utilization in sheep .
14982451	0	glucose	13,20	glucose_dehydrogenase	55,76	glucose	glucose dehydrogenase	MESH:D005947	9563	Chemical	Gene	oxidation|compound|START_ENTITY oxidation|nmod|END_ENTITY	Mechanism of glucose oxidation by quinoprotein soluble glucose_dehydrogenase : insights from molecular_dynamics studies .
2676668	0	glucose	66,73	glucose_dependent_insulinotropic_polypeptide	4,48	glucose	glucose dependent insulinotropic polypeptide	MESH:D005947	2695	Chemical	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	The glucose_dependent_insulinotropic_polypeptide response to oral glucose and mixed meals is increased in patients with type 2 -LRB- non-insulin-dependent -RRB- diabetes mellitus .
11134650	0	glucose	23,30	glucose_transporter_isotype_4	60,89	glucose	glucose transporter isotype 4	MESH:D005947	20528(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY Effect|nmod|uptake Effect|nmod|END_ENTITY	Effect of YM-126414 on glucose uptake and redistribution of glucose_transporter_isotype_4 in muscle cells .
11516624	0	glucose	23,30	glut1	43,48	glucose	glut1	MESH:D005947	6513	Chemical	Gene	accumulation|compound|START_ENTITY accumulation|amod|END_ENTITY	Endothelin-1 increases glucose transporter glut1 mRNA accumulation in 3T3-L1 adipocytes by a mitogen-activated protein kinase-dependent pathway .
10620325	8	glucose	1332,1339	glut_1	1277,1283	glucose	Glut 4	MESH:D005947	6517	Chemical	Gene	transport|compound|START_ENTITY stimulated|dobj|transport stimulated|nsubj|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of glut_1 stimulated basal and insulin-stimulated 2-deoxy glucose transport by 1.66 - and 1.43-fold , respectively .
8662691	0	glucose	11,18	glut_1	4,10	glucose	glut 1	MESH:D005947	100125988(Tax:9986)	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	The glut_1 glucose transporter interacts with calnexin and calreticulin .
10364240	0	glucose	65,72	glycogen_synthase_kinase_3beta	12,42	glucose	glycogen synthase kinase 3beta	MESH:D005947	2932	Chemical	Gene	metabolism|compound|START_ENTITY role|nmod|metabolism role|nmod|END_ENTITY	The role of glycogen_synthase_kinase_3beta in insulin-stimulated glucose metabolism .
18694957	0	glucose	58,65	glycogen_synthase_kinase_3beta	24,54	glucose	glycogen synthase kinase 3beta	MESH:D005947	56637(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY role|nmod|homeostasis role|nmod|END_ENTITY	Tissue-specific role of glycogen_synthase_kinase_3beta in glucose homeostasis and insulin action .
21855365	0	glucose	56,63	gonadotropin-releasing_hormone	14,44	glucose	gonadotropin-releasing hormone	MESH:D005947	2796	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|neurons neurons|amod|END_ENTITY	Regulation of gonadotropin-releasing_hormone neurons by glucose .
2561668	0	glucose	55,62	gp120	37,42	glucose	gp120	MESH:D005947	3700	Chemical	Gene	-RSB-|compound|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- AIDS and sleep_disorders : effect of gp120 on cerebral glucose metabolism -RSB- .
10077345	0	glucose	83,90	growth_hormone	17,31	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	differences|nmod|START_ENTITY Effects|nmod|differences Effects|nmod|END_ENTITY	Effects of human growth_hormone on the porto-arterial concentration differences of glucose and amino_acids in the newborn piglet .
10095165	0	glucose	38,45	growth_hormone	15,29	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	Suppression|nmod|START_ENTITY Suppression|nmod|END_ENTITY	Suppression of growth_hormone by oral glucose in the evaluation of tall stature .
1009678	0	glucose	49,56	growth_hormone	22,36	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	infusion|compound|START_ENTITY END_ENTITY|nmod|infusion	Suppression of plasma growth_hormone levels with glucose infusion in patients with acromegaly .
10376242	0	glucose	45,52	growth_hormone	88,102	glucose	growth hormone	MESH:D005947	102171600	Chemical	Gene	concentrations|nmod|START_ENTITY Changes|nmod|concentrations END_ENTITY|nsubj|Changes	Changes in plasma and milk concentrations of glucose and IGF-1 in response to exogenous growth_hormone in lactating goats .
10469015	0	glucose	15,22	growth_hormone	87,101	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	tolerance|dep|START_ENTITY Lipid|dobj|tolerance Lipid|nmod|years years|nmod|therapy therapy|amod|END_ENTITY	Lipid profile , glucose tolerance and insulin sensitivity after more than four years of growth_hormone therapy in non-growth_hormone deficient adolescents .
10803873	0	glucose	63,70	growth_hormone	37,51	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	metabolism|compound|START_ENTITY therapy|nmod|metabolism therapy|compound|END_ENTITY	The effect of 3 years of recombinant growth_hormone therapy on glucose metabolism in short Chinese children with beta-thalassemia major .
10903416	0	glucose	8,15	growth_hormone	104,118	glucose	growth hormone	MESH:D005947	81668(Tax:10116)	Chemical	Gene	utilization|compound|START_ENTITY Role|nmod|utilization Role|nmod|restoration restoration|nmod|cytochrome_P450_2E1 cytochrome_P450_2E1|nmod|END_ENTITY	Role of glucose utilization in the restoration of hypophysectomy-induced hepatic cytochrome_P450_2E1 by growth_hormone in rats .
10965213	0	glucose	54,61	growth_hormone	10,24	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	metabolism|compound|START_ENTITY Effect|nmod|metabolism Effect|nmod|treatment treatment|amod|END_ENTITY	Effect of growth_hormone and oxandrolone treatment on glucose metabolism in Turner_syndrome .
1104738	0	glucose	96,103	growth_hormone	41,55	glucose	growth hormone	MESH:D005947	81668(Tax:10116)	Chemical	Gene	metabolism|nummod|START_ENTITY release|nmod|metabolism release|nsubj|Effects Effects|nmod|replacement replacement|compound|END_ENTITY	Effects of hypophysectomy and short-term growth_hormone replacement on insulin release from and glucose metabolism in isolated rat islets of Langerhans .
11190985	0	glucose	43,50	growth_hormone	10,24	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	activity|compound|START_ENTITY Effect|nmod|activity Effect|nmod|END_ENTITY	Effect of growth_hormone on intestinal Na + / glucose cotransporter activity .
1133158	0	glucose	39,46	growth_hormone	78,92	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	loading|compound|START_ENTITY loading|nmod|secretion secretion|compound|END_ENTITY	Effectof sex , oral contraceptives , and glucose loading on apomorphine-induced growth_hormone secretion .
1152673	0	glucose	14,21	growth_hormone	29,43	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|response response|amod|END_ENTITY	The effect of glucose on the growth_hormone response to glucagon and propranolol-glucagon in normal subjects .
1158029	0	glucose	10,17	growth_hormone	25,39	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|response response|amod|END_ENTITY	Effect of glucose on the growth_hormone response to L-dopa in normal and diabetic subjects .
1161341	0	glucose	82,89	growth_hormone	26,40	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of endogenous growth_hormone , cortisol , and catecholamines with blood glucose in children with brittle_diabetes_mellitus .
11876939	0	glucose	72,79	growth_hormone	36,50	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	metabolism|nmod|START_ENTITY -LSB-|nmod|metabolism -LSB-|dobj|influence influence|nmod|END_ENTITY	-LSB- The influence of recombinant human growth_hormone on the metabolism of glucose and protein in severely burned patients -RSB- .
1248786	0	glucose	66,73	growth_hormone	36,50	glucose	growth hormone	MESH:D005947	81668(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY treatment|nmod|metabolism treatment|amod|END_ENTITY	Effects of hypophysectomy and acute growth_hormone treatment upon glucose metabolism in adipose tissues and isolated adipocytes of rats .
12818115	0	glucose	57,64	growth_hormone	29,43	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	metabolism|compound|START_ENTITY treatment|nmod|metabolism treatment|compound|END_ENTITY	-LSB- Effect of recombinant human growth_hormone treatment on glucose metabolism -RSB- .
1342220	0	glucose	129,136	growth_hormone	93,107	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	test|compound|START_ENTITY interfere|nmod|test interfere|nmod|interpretation interpretation|nmod|response response|amod|END_ENTITY	Do impaired_glucose_tolerance and diabetes_mellitus interfere with the interpretation of the growth_hormone response to the oral glucose tolerance test ?
1355580	0	glucose	44,51	growth_hormone	59,73	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	START_ENTITY|nmod|response response|amod|END_ENTITY	Arginine abolishes the inhibitory effect of glucose on the growth_hormone response to growth_hormone-releasing hormone in man .
1363137	0	glucose	103,110	growth_hormone	9,23	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	test|compound|START_ENTITY responses|nmod|test responses|nsubj|Abnormal Abnormal|amod|END_ENTITY	Abnormal growth_hormone and cortisol , but not thyroid-stimulating hormone , responses to an intravenous glucose tolerance test in normal-weight , bulimic women .
1483293	0	glucose	45,52	growth_hormone	9,23	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	induced|nmod|START_ENTITY rise|acl|induced rise|compound|END_ENTITY	The late growth_hormone rise induced by oral glucose is enhanced by cholinergic stimulation with pyridostigmine in normal subjects .
1490653	0	glucose	68,75	growth_hormone	23,37	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	profiles|compound|START_ENTITY profiles|compound|END_ENTITY	Twenty-four-hour serum growth_hormone , insulin , C-peptide and blood glucose profiles and serum insulin-like_growth_factor-I concentrations in women with polycystic_ovaries .
1494329	0	glucose	72,79	growth_hormone	29,43	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	test|compound|START_ENTITY Evaluation|nmod|test Evaluation|nmod|levels levels|amod|END_ENTITY	Evaluation of suppression of growth_hormone levels following a 75g oral glucose tolerance test .
15131760	0	glucose	35,42	growth_hormone	51,65	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	insulin|compound|START_ENTITY nicotine|nmod|insulin effects|nmod|nicotine END_ENTITY|nsubj|effects	Acute effects of nicotine on serum glucose insulin growth_hormone and cortisol in healthy smokers .
15191347	0	glucose	20,27	growth_hormone	66,80	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|nmod|fatty_acids fatty_acids|amod|END_ENTITY	Modulation of basal glucose metabolism and insulin sensitivity by growth_hormone and free fatty_acids during short-term fasting .
16263834	0	glucose	39,46	growth_hormone	21,35	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	Effects of high-dose growth_hormone on glucose and glycerol metabolism at rest and during exercise in endurance-trained athletes .
1675225	0	glucose	40,47	growth_hormone	22,36	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	metabolism|compound|START_ENTITY effects|nmod|metabolism effects|nmod|END_ENTITY	Short time effects of growth_hormone on glucose metabolism and insulin and glucagon secretion in normal man .
1684230	0	glucose	31,38	growth_hormone	49,63	glucose	growth hormone	MESH:D005947	81668(Tax:10116)	Chemical	Gene	excess|compound|START_ENTITY excess|nmod|END_ENTITY	Effects of acute and prolonged glucose excess on growth_hormone release by cultured rat anterior pituitary cells .
16912061	0	glucose	49,56	growth_hormone	110,124	glucose	growth hormone	MESH:D005947	81668(Tax:10116)	Chemical	Gene	utilization|compound|START_ENTITY modulate|dobj|utilization modulate|nmod|model model|nmod|deficiency deficiency|compound|END_ENTITY	Growth_hormone and IGF-I modulate local cerebral glucose utilization and ATP levels in a model of adult-onset growth_hormone deficiency .
17114888	0	glucose	57,64	growth_hormone	125,139	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	load|compound|START_ENTITY load|nmod|secretion secretion|compound|END_ENTITY	Acylated ghrelin secretion is acutely suppressed by oral glucose load or insulin-induced hypoglycemia independently of basal growth_hormone secretion in humans .
17192298	0	glucose	98,105	growth_hormone	14,28	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	load|compound|START_ENTITY effect|nmod|load effect|nmod|END_ENTITY	The effect of growth_hormone on the response of total and acylated ghrelin to a standardized oral glucose load and insulin resistance in children with Prader-Willi_syndrome .
17217656	0	glucose	47,54	growth_hormone	29,43	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	metabolism|compound|START_ENTITY Effect|nmod|metabolism Effect|nmod|END_ENTITY	-LSB- Effect of recombinant human growth_hormone on glucose metabolism in children with growth_hormone deficiency -RSB- .
17217656	0	glucose	47,54	growth_hormone	83,97	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	metabolism|compound|START_ENTITY Effect|nmod|metabolism Effect|nmod|children children|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Effect of recombinant human growth_hormone on glucose metabolism in children with growth_hormone deficiency -RSB- .
17336735	0	glucose	29,36	growth_hormone	11,25	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	metabolism|compound|START_ENTITY Effects|nmod|metabolism Effects|nmod|END_ENTITY	Effects of growth_hormone on glucose and fat metabolism in human subjects .
17337902	0	glucose	37,44	growth_hormone	11,25	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	metabolism|compound|START_ENTITY Effects|nmod|metabolism Effects|nmod|therapy therapy|amod|END_ENTITY	Effects of growth_hormone therapy on glucose metabolism and insulin sensitivity indices in prepubertal children with Prader-Willi_syndrome .
17341555	0	glucose	45,52	growth_hormone	106,120	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	fatty_acids|nmod|START_ENTITY effects|nmod|fatty_acids metabolism|nsubj|effects metabolism|nmod|blockade blockade|nmod|END_ENTITY	Dose-response effects of free fatty_acids on glucose and lipid metabolism during somatostatin blockade of growth_hormone and insulin in humans .
17347858	0	glucose	35,42	growth_hormone	96,110	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	load|compound|START_ENTITY response|nmod|load treated|nsubj|response treated|nmod|END_ENTITY	Plasma ghrelin response to an oral glucose load in growth_hormone-deficient adults treated with growth_hormone .
175208	0	glucose	35,42	growth_hormone	85,99	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	tolerance|compound|START_ENTITY tolerance|nmod|hypersecretion hypersecretion|nmod|END_ENTITY	-LSB- Influence of somatastatin on oral glucose tolerance in autonomous hypersecretion of growth_hormone , prolactin or insulin -LRB- author 's transl -RRB- -RSB- .
17709266	0	glucose	156,163	growth_hormone	31,45	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	control|compound|START_ENTITY effects|nmod|control pulses|dep|effects pulses|nmod|END_ENTITY	Frequent intravenous pulses of growth_hormone together with alanylglutamine supplementation in prolonged critical_illness after multiple_trauma : effects on glucose control , plasma IGF-I and glutamine .
17852425	0	glucose	40,47	growth_hormone	9,23	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	loading|compound|START_ENTITY Impaired|nmod|loading Impaired|dobj|secretion secretion|amod|END_ENTITY	Impaired growth_hormone secretion after glucose loading in non-obese women with polycystic_ovary_syndrome , possibly related to androgen but not insulin and free fatty_acids .
178683	0	glucose	44,51	growth_hormone	12,26	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	regulation|compound|START_ENTITY role|nmod|regulation role|nmod|END_ENTITY	The role of growth_hormone and cortisone on glucose and gluconeogenic substrate regulation in fasted hypopituitary children .
1806481	0	glucose	29,36	growth_hormone	11,25	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	metabolism|compound|START_ENTITY Effects|nmod|metabolism Effects|nmod|END_ENTITY	Effects of growth_hormone on glucose metabolism .
1850816	0	glucose	113,120	growth_hormone	64,78	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	requirements|compound|START_ENTITY reduce|dobj|requirements failure|acl|reduce failure|nmod|administration administration|compound|END_ENTITY	Hypoglycemia in hepatocellular_carcinoma : failure of short-term growth_hormone administration to reduce enhanced glucose requirements .
19240267	0	glucose	29,36	growth_hormone	11,25	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	lipid|compound|START_ENTITY Effects|nmod|lipid Effects|nmod|END_ENTITY	Effects of growth_hormone on glucose , lipid , and protein metabolism in human subjects .
19320648	0	glucose	22,29	growth_hormone	59,73	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	test|compound|START_ENTITY value|nmod|test END_ENTITY|nsubj|value	The value of the oral glucose tolerance test , random serum growth_hormone and mean growth_hormone levels in assessing the postoperative outcome of patients with acromegaly .
19320648	0	glucose	22,29	growth_hormone	83,97	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	test|compound|START_ENTITY value|nmod|test growth_hormone|nsubj|value growth_hormone|dobj|levels levels|amod|END_ENTITY	The value of the oral glucose tolerance test , random serum growth_hormone and mean growth_hormone levels in assessing the postoperative outcome of patients with acromegaly .
1943090	0	glucose	38,45	growth_hormone	20,34	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	utilization|compound|START_ENTITY END_ENTITY|nmod|utilization	Effect of exogenous growth_hormone on glucose utilization in burn patients .
1984566	0	glucose	56,63	growth_hormone	13,27	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	loading|compound|START_ENTITY END_ENTITY|nmod|loading	Responses of growth_hormone and cortisol to intravenous glucose loading test in patients with anorexia_nervosa .
20002779	0	glucose	127,134	growth_hormone	34,48	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	metabolism|compound|START_ENTITY effect|nmod|metabolism reduces|nmod|effect reduces|nsubj|END_ENTITY	Long-term high-physiological-dose growth_hormone reduces intra-abdominal fat in HIV-infected patients with a neutral effect on glucose metabolism .
20407232	0	glucose	26,33	growth_hormone	61,75	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	tolerance|compound|START_ENTITY deterioration|nmod|tolerance deterioration|nmod|therapy therapy|compound|END_ENTITY	Moderate deterioration in glucose tolerance during high-dose growth_hormone therapy in glucocorticoid-treated patients with juvenile_idiopathic_arthritis .
2108186	0	glucose	7,14	growth_hormone	62,76	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	modulate|nsubj|START_ENTITY modulate|dobj|secretion secretion|nmod|END_ENTITY	Plasma glucose and free fatty_acids modulate the secretion of growth_hormone , but not prolactin , in the rhesus and Java monkey .
2128272	0	glucose	95,102	growth_hormone	61,75	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	test|compound|START_ENTITY levels|nmod|test levels|compound|END_ENTITY	Evaluation of activity in postoperative acromegalics -- plasma growth_hormone levels during oral glucose tolerance test , daytime blood sampling and urinary GH excretion .
2129261	0	glucose	70,77	growth_hormone	43,57	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	load|compound|START_ENTITY END_ENTITY|nmod|load	Endogenous_hyperinsulinemia and release of growth_hormone following a glucose load as well as in response to thyrotropin_releasing_hormone in acromegaly .
2200623	0	glucose	30,37	growth_hormone	41,55	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	The effects of improved blood glucose on growth_hormone and cortisol secretion in insulin-dependent_diabetes_mellitus .
22074727	0	glucose	48,55	growth_hormone	111,125	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	parameters|compound|START_ENTITY parameters|nmod|subjects subjects|nmod|therapy therapy|amod|END_ENTITY	Incidence of diabetes_mellitus and evolution of glucose parameters in growth_hormone-deficient subjects during growth_hormone replacement therapy : a long-term observational study .
2254335	0	glucose	31,38	growth_hormone	63,77	glucose	growth hormone	MESH:D005947	81668(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY transporters|nsubj|regulation transporters|nmod|treatment treatment|compound|END_ENTITY	Differential regulation of two glucose transporters by chronic growth_hormone treatment of cultured 3T3-F442A adipose cells .
22565153	0	glucose	93,100	growth_hormone	35,49	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	metabolism|compound|START_ENTITY levels|nmod|metabolism Comparison|nmod|levels Comparison|nmod|regimens regimens|nmod|END_ENTITY	Comparison of two dose regimens of growth_hormone -LRB- GH -RRB- with different target IGF-1 levels on glucose metabolism , lipid profile , cardiovascular function and anthropometric parameters in gh-deficient adults .
226351	0	glucose	158,165	growth_hormone	133,147	glucose	growth hormone	MESH:D005947	81668(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY restricts|dobj|transport restricts|nsubj|END_ENTITY	Effects of insulin on glucose metabolism and glucose transport in fat cells of hormone-treated hypophysectomized rats : evidence that growth_hormone restricts glucose transport .
226351	0	glucose	22,29	growth_hormone	133,147	glucose	growth hormone	MESH:D005947	81668(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY insulin|nmod|metabolism Effects|nmod|insulin Effects|dep|evidence evidence|dep|restricts restricts|nsubj|END_ENTITY	Effects of insulin on glucose metabolism and glucose transport in fat cells of hormone-treated hypophysectomized rats : evidence that growth_hormone restricts glucose transport .
2273206	0	glucose	15,22	growth_hormone	62,76	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|secretion secretion|nmod|END_ENTITY	Interaction of glucose and pyridostigmine on the secretion of growth_hormone -LRB- GH -RRB- induced by GH-releasing_hormone -LRB- GHRH -RRB- .
24498035	0	glucose	53,60	growth_hormone	11,25	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	metabolism|compound|START_ENTITY withdrawal|nmod|metabolism withdrawal|amod|END_ENTITY	Effects of growth_hormone -LRB- GH -RRB- therapy withdrawal on glucose metabolism in not confirmed GH_deficient adolescents at final height .
2503912	0	glucose	64,71	growth_hormone	6,20	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	Serum|nmod|START_ENTITY Serum|dobj|responses responses|compound|END_ENTITY	Serum growth_hormone , insulin and blood sugar responses to oral glucose in protein_energy_malnutrition .
2567576	0	glucose	46,53	growth_hormone	28,42	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	counterregulation|compound|START_ENTITY Demonstration|nmod|counterregulation Demonstration|nmod|role role|nmod|END_ENTITY	Demonstration of a role for growth_hormone in glucose counterregulation .
26774402	0	glucose	42,49	growth_hormone	66,80	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	dynamics|compound|START_ENTITY dynamics|nmod|response response|amod|END_ENTITY	Effects of gender , body weight , and blood glucose dynamics on the growth_hormone response to the glucagon stimulation test in patients with pituitary_disease .
2859524	1	glucose	102,109	growth_hormone	181,195	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	production|compound|START_ENTITY surges|nsubj|production surges|nmod|secretion secretion|amod|END_ENTITY	Accelerated glucose production and impaired_glucose_utilization due to nocturnal surges in growth_hormone secretion .
2870845	0	glucose	29,36	growth_hormone	11,25	glucose	growth hormone	MESH:D005947	443329(Tax:9940)	Chemical	Gene	metabolism|compound|START_ENTITY Effects|nmod|metabolism Effects|nmod|END_ENTITY	Effects of growth_hormone on glucose and acetate metabolism in sheep .
2872493	0	glucose	52,59	growth_hormone	27,41	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Effect of propantheline on growth_hormone and blood glucose levels .
2879210	0	glucose	81,88	growth_hormone	18,32	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	clamp|compound|START_ENTITY END_ENTITY|nmod|clamp	Changes in plasma growth_hormone in diabetic and nondiabetic subjects during the glucose clamp .
2894751	0	glucose	39,46	growth_hormone	14,28	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	regulation|compound|START_ENTITY END_ENTITY|nmod|regulation	Importance of growth_hormone for blood glucose regulation following insulin-induced nocturnal_hypoglycemia in insulin-dependent_diabetes_mellitus .
3089892	0	glucose	89,96	growth_hormone	62,76	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	load|compound|START_ENTITY END_ENTITY|nmod|load	Impaired_glucose_tolerance coincides with abnormal release of growth_hormone following a glucose load as well as in response to TRH in acromegaly .
3150778	0	glucose	92,99	growth_hormone	57,71	glucose	growth hormone	MESH:D005947	443329(Tax:9940)	Chemical	Gene	stimulated|nmod|START_ENTITY stimulated|dobj|secretion secretion|amod|END_ENTITY	Modulation of growth_hormone-releasing factor stimulated growth_hormone secretion by plasma glucose and free fatty_acid concentrations in sheep .
3289300	0	glucose	54,61	growth_hormone	29,43	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	The effect of pirenzepine on growth_hormone and blood glucose levels in type_I_diabetes_mellitus .
3359981	0	glucose	29,36	growth_hormone	11,25	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	Effects of growth_hormone on glucose metabolism and glucose transport in 3T3-F442A cells : dependence on cell differentiation .
343464	0	glucose	19,26	growth_hormone	37,51	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	Variation|nmod|START_ENTITY Variation|amod|END_ENTITY	Variation of blood glucose and serum growth_hormone , prolactin and insulin in subjects with insulin-dependent_diabetes , after OGTT and pretreatment with 2-Br-alpha-ergocryptine .
3531193	0	glucose	43,50	growth_hormone	15,29	glucose	growth hormone	MESH:D005947	14599(Tax:10090)	Chemical	Gene	synthesis|nmod|START_ENTITY synthesis|amod|END_ENTITY	Stimulation of growth_hormone synthesis by glucose in islets of Langerhans isolated from transgenic_mice .
3531761	6	glucose	1101,1108	growth_hormone	1166,1180	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	concentrations|nmod|START_ENTITY reproduce|dobj|concentrations designed|xcomp|reproduce clamp|dep|designed received|dobj|clamp received|nmod|administration administration|amod|END_ENTITY	In a second study , six patients received a low-dose insulin clamp -LRB- designed to reproduce the mean postprandial concentrations of glucose and insulin observed in the meal study -RRB- before and after growth_hormone administration .
3605693	0	glucose	17,24	growth_hormone	35,49	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	Changes|nmod|START_ENTITY END_ENTITY|nsubj|Changes	Changes in serum glucose and serum growth_hormone levels during pituitary surgery .
36413	0	glucose	62,69	growth_hormone	38,52	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	counterregulation|compound|START_ENTITY END_ENTITY|nmod|counterregulation	Role of glucagon , catecholamines , and growth_hormone in human glucose counterregulation .
3886369	0	glucose	47,54	growth_hormone	6,20	glucose	growth hormone	MESH:D005947	81668(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY alters|dobj|metabolism alters|nsubj|deficiency deficiency|compound|END_ENTITY	Acute growth_hormone deficiency rapidly alters glucose metabolism in rat adipocytes .
395097	0	glucose	34,41	growth_hormone	128,142	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	days|nmod|START_ENTITY effect|nmod|days normalization|nsubj|effect normalization|nmod|means means|nmod|artificial_endocrine_pancreas artificial_endocrine_pancreas|nmod|concentrations concentrations|nmod|END_ENTITY	The effect of three days of blood glucose normalization by means of an `` artificial_endocrine_pancreas '' on the concentrations of growth_hormone , glucagon , and cortisol in juvenile diabetics .
5449094	0	glucose	65,72	growth_hormone	11,25	glucose	growth hormone	MESH:D005947	81668(Tax:10116)	Chemical	Gene	exert|nmod|START_ENTITY END_ENTITY|acl|exert	Failure of growth_hormone to exert an acute inhibitory effect on glucose uptake in the rat diaphragm .
564386	0	glucose	185,192	growth_hormone	11,25	glucose	growth hormone	MESH:D005947	102171600	Chemical	Gene	fatty_acids|compound|START_ENTITY Release|appos|fatty_acids Release|nmod|END_ENTITY	Release of growth_hormone in lactating and non-lactating goats in relation to behaviour , stages of sleep , electroencephalograms , environmental stimuli and levels of prolactin , insulin , glucose and free fatty_acids in the circulation .
579023	1	glucose	147,154	growth_hormone	113,127	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	tests|compound|START_ENTITY levels|nmod|tests levels|compound|END_ENTITY	I. Glucose , insulin and human growth_hormone levels during oral glucose tolerance tests .
5929631	0	glucose	60,67	growth_hormone	30,44	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	hypersecretion|nmod|START_ENTITY hypersecretion|nmod|END_ENTITY	Paradoxical hypersecretion of growth_hormone in response to glucose .
5948569	0	glucose	58,65	growth_hormone	113,127	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	metabolism|compound|START_ENTITY contribution|nmod|metabolism Estimation|nmod|contribution Estimation|nmod|END_ENTITY	Estimation of the glucuronic_acid pathway contribution to glucose metabolism in adipose tissue and the effect of growth_hormone .
598566	0	glucose	87,94	growth_hormone	29,43	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	administration|compound|START_ENTITY induced|nmod|administration induced|dobj|release release|amod|END_ENTITY	Inhibition of L-dopa induced growth_hormone release in normal and diabetic subjects by glucose administration .
6166466	0	glucose	114,121	growth_hormone	76,90	glucose	growth hormone	MESH:D005947	81668(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY adipocytes|nmod|transport adipocytes|nmod|END_ENTITY	In vivo control of insulin-sensitive phosphodiesterase in rat adipocytes by growth_hormone and its parallelism to glucose transport .
626554	3	glucose	609,616	growth_hormone	388,402	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	administration|nmod|START_ENTITY induced|nmod|administration orally|acl|induced growth_hormone|nmod|orally suppression|nmod|growth_hormone lack|nmod|suppression characterized|nmod|lack regulation|acl|characterized regulation|amod|END_ENTITY	In addition we demonstrated alterations in growth_hormone regulation , characterized by -LRB- 1 -RRB- the lack of suppression of growth_hormone by orally induced hyperglycemia and paradoxical increase in serum levels of growth_hormone after the administration of intravenous glucose or glucagon ; -LRB- 2 -RRB- lack of release of growth_hormone with induced hypoglycemia and an exaggerated response to levodopa administration .
6282041	0	glucose	37,44	growth_hormone	77,91	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	infusion|nmod|START_ENTITY Effect|nmod|infusion Effect|amod|END_ENTITY	Effect of glucagon infusion on blood glucose , plasma immunoreactive insulin , growth_hormone and adenosine_3 ' 5 ' - monophosphate in obese children .
6336611	0	glucose	28,35	growth_hormone	49,63	glucose	growth hormone	MESH:D005947	81668(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY transport|nmod|END_ENTITY	Regulation of rat adipocyte glucose transport by growth_hormone : no mediation by insulin-like growth factors .
6338346	0	glucose	50,57	growth_hormone	23,37	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	tolerance|compound|START_ENTITY END_ENTITY|nmod|tolerance	Paradoxical release of growth_hormone during oral glucose tolerance test in patients with abnormal_glucose_tolerance .
6341144	0	glucose	33,40	growth_hormone	10,24	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	tolerance|compound|START_ENTITY END_ENTITY|nmod|tolerance	Effect of growth_hormone on oral glucose tolerance and circulating metabolic fuels in man .
6343098	0	glucose	36,43	growth_hormone	20,34	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	insulin|dep|START_ENTITY insulin|compound|END_ENTITY	Effect of l-dopa on growth_hormone , glucose , insulin , and cortisol response in obese subjects .
6360765	0	glucose	91,98	growth_hormone	14,28	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	loading|compound|START_ENTITY effect|nmod|loading effect|nmod|END_ENTITY	The effect of growth_hormone on splanchnic_glucose_and_substrate_metabolism following oral glucose loading in healthy man .
6377008	0	glucose	49,56	growth_hormone	23,37	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	uptake|compound|START_ENTITY inhibit|dobj|uptake END_ENTITY|xcomp|inhibit	Direct effect of human growth_hormone to inhibit glucose uptake in cultured human fibroblasts .
6424979	0	glucose	21,28	growth_hormone	36,50	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	START_ENTITY|nmod|response response|amod|END_ENTITY	The effect of plasma glucose on the growth_hormone response to human pancreatic growth_hormone_releasing_factor in normal subjects .
6435366	0	glucose	89,96	growth_hormone	55,69	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	load|compound|START_ENTITY treated|nmod|load treated|nmod|levels levels|compound|END_ENTITY	Evaluation of treated acromegalic patients with normal growth_hormone levels during oral glucose load .
6439436	0	glucose	5,12	growth_hormone	22,36	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|amod|END_ENTITY	Oral glucose inhibits growth_hormone secretion induced by human pancreatic growth_hormone releasing factor 1-44 in normal man .
6439436	0	glucose	5,12	growth_hormone	75,89	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|acl|induced induced|nmod|END_ENTITY	Oral glucose inhibits growth_hormone secretion induced by human pancreatic growth_hormone releasing factor 1-44 in normal man .
6779470	0	glucose	8,15	growth_hormone	96,110	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	incorporation|compound|START_ENTITY incorporation|acl|END_ENTITY	Reduced glucose incorporation to triglycerides following chronic exposure of human fat cells to growth_hormone .
7042427	0	glucose	102,109	growth_hormone	127,141	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	START_ENTITY|appos|levels levels|compound|END_ENTITY	Insulin absorption from the abdomen and the thigh in healthy subjects during rest and exercise : blood glucose , plasma insulin , growth_hormone , adrenaline and noradrenaline levels .
7203397	0	glucose	10,17	growth_hormone	21,35	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|response response|compound|prolactin prolactin|compound|END_ENTITY	Effect of glucose of growth_hormone , prolactin and thyroid-stimulating hormone response to diazepam in normal subjects .
7214254	1	glucose	75,82	growth_hormone	92,106	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nsubj|effect	The effect of ingested glucose on serum growth_hormone in homozygotes , obligate heterozygotes and potential carriers of the Friedreich 's _ ataxia gene .
7623425	0	glucose	38,45	growth_hormone	10,24	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	tolerance|compound|START_ENTITY Effect|nmod|tolerance Effect|nmod|treatment treatment|amod|END_ENTITY	Effect of growth_hormone treatment on glucose tolerance in a patient with cystinosis after kidney transplantation .
7943225	0	glucose	36,43	growth_hormone	10,24	glucose	growth hormone	MESH:D005947	403795(Tax:9615)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of growth_hormone on hepatic glucose and insulin metabolism after oral glucose in conscious dogs .
7943225	0	glucose	78,85	growth_hormone	10,24	glucose	growth hormone	MESH:D005947	403795(Tax:9615)	Chemical	Gene	glucose|nmod|START_ENTITY Effect|nmod|glucose Effect|nmod|END_ENTITY	Effect of growth_hormone on hepatic glucose and insulin metabolism after oral glucose in conscious dogs .
8033949	0	glucose	80,87	growth_hormone	26,40	glucose	growth hormone	MESH:D005947	81668(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY rates|nmod|transport Studies|nmod|rates Studies|nmod|effects effects|nmod|administration administration|amod|END_ENTITY	Studies on the effects of growth_hormone administration in vivo on the rates of glucose transport and utilization in rat skeletal muscle .
8112721	0	glucose	93,100	growth_hormone	8,22	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	levels|compound|START_ENTITY course|nmod|levels relation|nmod|course excretion|dep|relation excretion|amod|END_ENTITY	Urinary growth_hormone excretion in diabetic children : relation to nocturnal course of blood glucose levels .
8118430	0	glucose	63,70	growth_hormone	45,59	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	transport|compound|START_ENTITY Effect|nmod|transport Effect|nmod|fragment fragment|nmod|END_ENTITY	Effect of an antilipogenic fragment of human growth_hormone on glucose transport in rat adipocytes .
815150	0	glucose	12,19	growth_hormone	126,140	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|nmod|patients patients|nmod|liver_cirrhosis liver_cirrhosis|nmod|relation relation|nmod|levels levels|nmod|END_ENTITY	-LSB- Studies on glucose , amino_acid and protein metabolism in patients with liver_cirrhosis in relation to plasma levels of human growth_hormone -LRB- author 's transl -RRB- -RSB- .
8359785	0	glucose	51,58	growth_hormone	25,39	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	metabolism|compound|START_ENTITY effect|nmod|metabolism effect|nmod|therapy therapy|amod|END_ENTITY	Dose-dependent effect of growth_hormone therapy on glucose metabolism in subjects with Turner_syndrome .
8609830	0	glucose	70,77	growth_hormone	27,41	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	production|compound|START_ENTITY augment|dobj|production augment|nsubj|END_ENTITY	Adjuvant recombinant human growth_hormone does not augment endogenous glucose production in total parenteral nutrition-fed multiple_trauma patients .
8895392	0	glucose	135,142	growth_hormone	2,16	glucose	growth hormone	MESH:D005947	14599(Tax:10090)	Chemical	Gene	hemoglobin|compound|START_ENTITY levels|nmod|hemoglobin presence|nmod|levels protects|nmod|presence protects|nsubj|antagonist antagonist|amod|END_ENTITY	A growth_hormone antagonist protects mice against streptozotocin induced glomerulosclerosis even in the presence of elevated levels of glucose and glycated hemoglobin .
8938588	0	glucose	42,49	growth_hormone	11,25	glucose	growth hormone	MESH:D005947	81668(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY vitro|nmod|metabolism beta-cells|amod|vitro Effects|nmod|beta-cells Effects|nmod|END_ENTITY	Effects of growth_hormone in vitro on the glucose metabolism of fetal rat islet beta-cells .
8950620	0	glucose	26,33	growth_hormone	8,22	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	counterregulation|compound|START_ENTITY Role|nmod|counterregulation Role|nmod|END_ENTITY	Role of growth_hormone in glucose counterregulation .
9280070	0	glucose	113,120	growth_hormone	70,84	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	uptake|compound|START_ENTITY uptake|amod|END_ENTITY	Phosphoinositide 3-kinase is required for insulin-induced but not for growth_hormone - or hyperosmolarity-induced glucose uptake in 3T3-L1 adipocytes .
9418684	0	glucose	16,23	growth_hormone	49,63	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	administration|compound|START_ENTITY Effects|nmod|administration END_ENTITY|nsubj|Effects	Effects of oral glucose administration on plasma growth_hormone levels in women with polycystic_ovary_syndrome .
9438920	0	glucose	25,32	growth_hormone	36,50	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	The inhibitory effect of glucose on growth_hormone secretion is lost in obesity but not in hypertension .
946563	0	glucose	50,57	growth_hormone	68,82	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	sensitivity|nmod|START_ENTITY sensitivity|nmod|influsion influsion|amod|END_ENTITY	Diminished sensitivity of the insulin response to glucose following growth_hormone influsion in man .
9579229	0	glucose	109,116	growth_hormone	73,87	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	test|compound|START_ENTITY responsible|nmod|test responsible|nmod|response response|compound|END_ENTITY	The altered plasma amino_acid pattern is responsible for the paradoxical growth_hormone response to the oral glucose tolerance test in liver_cirrhosis .
9685999	0	glucose	45,52	growth_hormone	22,36	glucose	growth hormone	MESH:D005947	2688	Chemical	Gene	tolerance|compound|START_ENTITY END_ENTITY|nmod|tolerance	-LSB- Abnormal response of growth_hormone to oral glucose tolerance test in obesity -RSB- .
3097059	0	glucose	15,22	growth_hormone-releasing_hormone	48,80	glucose	growth hormone-releasing hormone	MESH:D005947	2691	Chemical	Gene	administration|compound|START_ENTITY Effect|nmod|administration Effect|nmod|END_ENTITY	Effect of oral glucose administration on plasma growth_hormone-releasing_hormone -LRB- GHRH -RRB- - like immunoreactivity levels in normal subjects and patients with idiopathic_GH_deficiency : evidence that GHRH is released not only from the hypothalamus but also from extrahypothalamic tissue .
11024018	0	glucose	66,73	hSGLT1	87,93	glucose	hSGLT1	MESH:D005947	6523	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Neutralization of a conserved amino_acid residue in the human Na + / glucose transporter -LRB- hSGLT1 -RRB- generates a glucose-gated H + channel .
12885248	0	glucose	38,45	hSGLT1	59,65	glucose	hSGLT1	MESH:D005947	6523	Chemical	Gene	transporter|compound|START_ENTITY asymmetry|nmod|transporter asymmetry|appos|END_ENTITY	Functional asymmetry of the human Na + / glucose transporter -LRB- hSGLT1 -RRB- in bacterial membrane vesicles .
17130520	0	glucose	45,52	hSGLT1	27,33	glucose	hSGLT1	MESH:D005947	6523	Chemical	Gene	cotransport|compound|START_ENTITY dynamics|nmod|cotransport dynamics|nmod|END_ENTITY	Conformational dynamics of hSGLT1 during Na + / glucose cotransport .
1284964	0	glucose	25,32	hexokinase	14,24	glucose	hexokinase	MESH:D005947	851167(Tax:4932)	Chemical	Gene	site|compound|START_ENTITY site|amod|END_ENTITY	Exploring the hexokinase glucose binding site through correlation analysis and molecular modeling of glucosamine inhibitors .
14507429	0	glucose	18,25	hexokinase	161,171	glucose	hexokinase	MESH:D005947	851167(Tax:4932)	Chemical	Gene	defect|compound|START_ENTITY Uncoupling|nmod|defect mutants|nsubj|Uncoupling mutants|xcomp|expressing expressing|dobj|END_ENTITY	Uncoupling of the glucose growth defect and the deregulation of glycolysis in Saccharomyces_cerevisiae Tps1 mutants expressing trehalose-6-phosphate-insensitive hexokinase from Schizosaccharomyces_pombe .
1465437	0	glucose	89,96	hexokinase	20,30	glucose	hexokinase	MESH:D005947	851167(Tax:4932)	Chemical	Gene	reduces|dobj|START_ENTITY reduces|nsubj|Expression Expression|nmod|END_ENTITY	Expression of yeast hexokinase in pancreatic beta cells of transgenic_mice reduces blood glucose , enhances insulin secretion , and decreases diabetes .
23382859	0	glucose	108,115	hexokinase	72,82	glucose	hexokinase	MESH:D005947	102604144	Chemical	Gene	phosphorylation|compound|START_ENTITY exerts|nmod|phosphorylation exerts|nsubj|END_ENTITY	The futile cycling of hexose phosphates could account for the fact that hexokinase exerts a high control on glucose phosphorylation but not on glycolytic rate in transgenic potato -LRB- Solanum_tuberosum -RRB- roots .
25163631	0	glucose	63,70	hexokinase	19,29	glucose	hexokinase	MESH:D005947	851167(Tax:4932)	Chemical	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	The involvement of hexokinase in the coordinated regulation of glucose and gibberellin on cell wall invertase and sucrose synthesis in grape berry .
25668	0	glucose	32,39	hexokinase	57,67	glucose	hexokinase	MESH:D005947	851167(Tax:4932)	Chemical	Gene	study|nmod|START_ENTITY binding|nsubj|study binding|nmod|isoenzymes isoenzymes|compound|END_ENTITY	Fluorescence-quenching study of glucose binding by yeast hexokinase isoenzymes .
2685572	0	glucose	92,99	hexokinase	51,61	glucose	hexokinase	MESH:D005947	851167(Tax:4932)	Chemical	Gene	repression|compound|START_ENTITY correlated|nmod|repression correlated|nsubjpass|activity activity|nmod|mutants mutants|amod|END_ENTITY	The residual enzymatic phosphorylation activity of hexokinase II mutants is correlated with glucose repression in Saccharomyces_cerevisiae .
3042027	0	glucose	23,30	hexokinase	52,62	glucose	hexokinase	MESH:D005947	851167(Tax:4932)	Chemical	Gene	binding|nmod|START_ENTITY binding|acl|END_ENTITY	Synergistic binding of glucose and aluminium_ATP to hexokinase from Saccharomyces_cerevisiae .
3276353	0	glucose	15,22	hexokinase	42,52	glucose	hexokinase	MESH:D005947	851167(Tax:4932)	Chemical	Gene	binding|nmod|START_ENTITY binding|acl|END_ENTITY	The binding of glucose and nucleotides to hexokinase from Saccharomyces_cerevisiae .
369601	0	glucose	81,88	hexokinase	6,16	glucose	hexokinase	MESH:D005947	851167(Tax:4932)	Chemical	Gene	exhibits|nmod|START_ENTITY exhibits|nsubj|END_ENTITY	Yeast hexokinase in solution exhibits a large conformational change upon binding glucose or glucose_6-phosphate .
6394965	0	glucose	139,146	hexokinase	11,21	glucose	hexokinase	MESH:D005947	851167(Tax:4932)	Chemical	Gene	repression|compound|START_ENTITY PII|nmod|repression role|nmod|PII confirm|dobj|role PI|parataxis|confirm PI|nsubj|Cloning Cloning|nmod|isoenzyme isoenzyme|amod|END_ENTITY	Cloning of hexokinase isoenzyme PI from Saccharomyces_cerevisiae : PI transformants confirm the unique role of hexokinase isoenzyme PII for glucose repression in yeasts .
6394965	0	glucose	139,146	hexokinase	110,120	glucose	hexokinase	MESH:D005947	851167(Tax:4932)	Chemical	Gene	repression|compound|START_ENTITY PII|nmod|repression PII|amod|END_ENTITY	Cloning of hexokinase isoenzyme PI from Saccharomyces_cerevisiae : PI transformants confirm the unique role of hexokinase isoenzyme PII for glucose repression in yeasts .
7000190	0	glucose	11,18	hexokinase	63,73	glucose	hexokinase	MESH:D005947	851167(Tax:4932)	Chemical	Gene	ion|compound|START_ENTITY ion|nmod|quenching quenching|nmod|END_ENTITY	Effects of glucose and magnesium ion on the quenching of yeast hexokinase fluorescence by acrylamide .
7052060	0	glucose	15,22	hexokinase	32,42	glucose	hexokinase	MESH:D005947	851167(Tax:4932)	Chemical	Gene	START_ENTITY|nmod|monomers monomers|compound|END_ENTITY	The binding of glucose to yeast hexokinase monomers is independent of ionic strength .
8321195	0	glucose	70,77	hexokinase	4,14	glucose	hexokinase	MESH:D005947	851167(Tax:4932)	Chemical	Gene	RAG1|compound|START_ENTITY regulation|nmod|RAG1 required|nmod|regulation required|nsubjpass|gene gene|amod|END_ENTITY	The hexokinase gene is required for transcriptional regulation of the glucose transporter gene RAG1 in Kluyveromyces_lactis .
8595874	0	glucose	57,64	hexokinase	20,30	glucose	hexokinase	MESH:D005947	851167(Tax:4932)	Chemical	Gene	repression|compound|START_ENTITY prevent|dobj|repression prevent|nsubj|inactivation inactivation|nmod|activity activity|amod|END_ENTITY	The inactivation of hexokinase activity does not prevent glucose repression in Candida utilis .
8674991	0	glucose	131,138	hexokinase	117,127	glucose	hexokinase	MESH:D005947	851167(Tax:4932)	Chemical	Gene	repression|compound|START_ENTITY END_ENTITY|nmod|repression	Characterisation of the Aspergillus_nidulans frA1 mutant : hexose phosphorylation and apparent lack of involvement of hexokinase in glucose repression .
9493266	0	glucose	136,143	hexokinase	110,120	glucose	hexokinase	MESH:D005947	851167(Tax:4932)	Chemical	Gene	complexed|nmod|START_ENTITY insights|dep|complexed insights|nmod|structure structure|nmod|END_ENTITY	The mechanism of regulation of hexokinase : new insights from the crystal structure of recombinant human brain hexokinase complexed with glucose and glucose-6-phosphate .
9493266	0	glucose	136,143	hexokinase	31,41	glucose	hexokinase	MESH:D005947	851167(Tax:4932)	Chemical	Gene	complexed|nmod|START_ENTITY insights|dep|complexed mechanism|dep|insights mechanism|nmod|regulation regulation|nmod|END_ENTITY	The mechanism of regulation of hexokinase : new insights from the crystal structure of recombinant human brain hexokinase complexed with glucose and glucose-6-phosphate .
11574402	0	glucose	120,127	hormone-sensitive_lipase	18,42	glucose	hormone-sensitive lipase	MESH:D005947	25330(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|expression expression|nmod|END_ENTITY	The expression of hormone-sensitive_lipase in clonal beta-cells and rat islets is induced by long-term exposure to high glucose .
16162821	0	glucose	93,100	hormone-sensitive_lipase	23,47	glucose	hormone-sensitive lipase	MESH:D005947	25330(Tax:10116)	Chemical	Gene	reducing|dobj|START_ENTITY improves|advcl|reducing improves|nsubj|inhibition inhibition|nmod|END_ENTITY	Specific inhibition of hormone-sensitive_lipase improves lipid profile while reducing plasma glucose .
9571185	0	glucose	53,60	hormone-sensitive_lipase	14,38	glucose	hormone-sensitive lipase	MESH:D005947	3991	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of hormone-sensitive_lipase expression by glucose in 3T3-F442A adipocytes .
26440713	2	glucose	314,321	humans	336,342	glucose	MTNR1B	MESH:D005947	4544	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|nmod|END_ENTITY	To date , no experimental study has tested the effect of the MTNR1B variant on glucose metabolism in humans during exposure of the melatonin receptors to their ligand .
18367282	0	glucose	143,150	hxt1	38,42	glucose	hxt1	MESH:D005947	856494(Tax:4932)	Chemical	Gene	concentration|compound|START_ENTITY perturbations|nmod|concentration response|nmod|perturbations response|nmod|expression expression|nmod|proteins proteins|amod|END_ENTITY	Dynamic response of the expression of hxt1 , hxt5 and hxt7 transport proteins in Saccharomyces_cerevisiae to perturbations in the extracellular glucose concentration .
23377827	0	glucose	7,14	hypoxia-inducible_factor-1a	23,50	glucose	hypoxia-inducible factor-1a	MESH:D005947	3091	Chemical	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Excess glucose induces hypoxia-inducible_factor-1a in pancreatic_cancer cells and stimulates glucose metabolism and cell migration .
24221993	0	glucose	35,42	hypoxia-inducible_factor-1a	96,123	glucose	hypoxia-inducible factor-1a	MESH:D005947	3091	Chemical	Gene	uptake|compound|START_ENTITY suppresses|dobj|uptake suppresses|advcl|targeting targeting|dobj|oxygen oxygen|dep|activation activation|amod|END_ENTITY	Resveratrol suppresses cancer cell glucose uptake by targeting reactive oxygen species-mediated hypoxia-inducible_factor-1a activation .
16635563	0	glucose	103,110	inducible_nitric_oxide_synthase	23,54	glucose	inducible nitric oxide synthase	MESH:D005947	24599(Tax:10116)	Chemical	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	Selective induction of inducible_nitric_oxide_synthase in pancreatic islet of rat after an intravenous glucose or intralipid challenge .
10064097	0	glucose	100,107	insulin	80,87	glucose	insulin	MESH:D005947	3630	Chemical	Gene	associated|nmod|START_ENTITY associated|nmod|response response|compound|END_ENTITY	Hyperproinsulinaemia in impaired_glucose_tolerance is associated with a delayed insulin response to glucose .
10084563	0	glucose	129,136	insulin	22,29	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY explain|nmod|tolerance explain|nsubj|changes changes|nmod|concentration concentration|compound|END_ENTITY	Can changes in plasma insulin concentration explain the variability in leptin response to weight_loss in obese women with normal glucose tolerance ?
10095815	0	glucose	36,43	insulin	82,89	glucose	insulin	MESH:D005947	3630	Chemical	Gene	profile|compound|START_ENTITY critical|nmod|profile critical|nmod|treatment treatment|nmod|preprandially preprandially|compound|END_ENTITY	The snack is critical for the blood glucose profile during treatment with regular insulin preprandially .
10198313	0	glucose	66,73	insulin	16,23	glucose	insulin	MESH:D005947	3630	Chemical	Gene	transport|compound|START_ENTITY relation|nmod|transport resistance|dep|relation resistance|compound|END_ENTITY	Surgery-induced insulin resistance in human patients : relation to glucose transport and utilization .
1020565	0	glucose	46,53	insulin	17,24	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	administration|compound|START_ENTITY secretion|nmod|administration secretion|nsubj|mechanism mechanism|nmod|END_ENTITY	The mechanism of insulin secretion after oral glucose administration .
10320056	0	glucose	123,130	insulin	59,66	glucose	insulin	MESH:D005947	3630	Chemical	Gene	transport|compound|START_ENTITY association|nmod|transport pseudoacromegaly|dep|association pseudoacromegaly|nmod|patient patient|nmod|resistance resistance|compound|END_ENTITY	Insulin-mediated pseudoacromegaly in a patient with severe insulin resistance : association of defective insulin-stimulated glucose transport with impaired phosphatidylinositol 3-kinase activity in fibroblasts .
10321421	0	glucose	28,35	insulin	111,118	glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY control|nmod|mix25 mix25|compound|END_ENTITY	Improved postprandial blood glucose control and reduced nocturnal_hypoglycemia during treatment with two novel insulin lispro-protamine formulations , insulin lispro mix25 and insulin lispro mix50 .
10321421	0	glucose	28,35	insulin	150,157	glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY control|nmod|mix25 mix25|compound|END_ENTITY	Improved postprandial blood glucose control and reduced nocturnal_hypoglycemia during treatment with two novel insulin lispro-protamine formulations , insulin lispro mix25 and insulin lispro mix50 .
10372690	0	glucose	86,93	insulin	50,57	glucose	insulin	MESH:D005947	3630	Chemical	Gene	stimulus|compound|START_ENTITY release|nmod|stimulus release|nsubj|Disruption Disruption|nmod|modes modes|nmod|END_ENTITY	Disruption of the pulsatile and entropic modes of insulin release during an unvarying glucose stimulus in elderly individuals .
10382587	0	glucose	58,65	insulin	14,21	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY range|nmod|tolerance tests|nmod|range tests|nsubj|Comparison Comparison|nmod|sensitivity sensitivity|compound|END_ENTITY	Comparison of insulin sensitivity tests across a range of glucose tolerance from normal to diabetes .
10390156	0	glucose	34,41	insulin	18,25	glucose	insulin	MESH:D005947	3630	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Regulation of the insulin gene by glucose : stimulation of trans-activation potency of human PDX-1 N-terminal domain .
10440123	0	glucose	9,16	insulin	62,69	glucose	insulin	MESH:D005947	3630	Chemical	Gene	transport|compound|START_ENTITY kinase|nsubj|transport kinase|nmod|END_ENTITY	Impaired glucose transport and protein kinase B activation by insulin , but not okadaic_acid , in adipocytes from subjects with Type_II_diabetes_mellitus .
10457152	0	glucose	36,43	insulin	10,17	glucose	insulin	MESH:D005947	3630	Chemical	Gene	transfer|compound|START_ENTITY increase|dobj|transfer increase|nsubj|END_ENTITY	High dose insulin does not increase glucose transfer across the blood-brain barrier in humans : a re-evaluation .
10480766	0	glucose	55,62	insulin	17,24	glucose	insulin	MESH:D005947	3630	Chemical	Gene	levels|compound|START_ENTITY correct|dobj|levels Use|xcomp|correct Use|nmod|guide guide|compound|END_ENTITY	Use of a plastic insulin dosage guide to correct blood glucose levels out of the target range and for carbohydrate counting in subjects with type 1 diabetes .
10491343	0	glucose	84,91	insulin	45,52	glucose	insulin	MESH:D005947	3630	Chemical	Gene	loads|compound|START_ENTITY END_ENTITY|nmod|loads	Splanchnic and extrasplanchnic extraction of insulin following oral and intravenous glucose loads .
10512354	0	glucose	24,31	insulin	13,20	glucose	insulin	MESH:D005947	3630	Chemical	Gene	transport|amod|START_ENTITY effect|nmod|transport effect|nmod|END_ENTITY	No effect of insulin on glucose blood-brain barrier transport and cerebral metabolism in humans .
10532502	0	glucose	46,53	insulin	14,21	glucose	insulin	MESH:D005947	3630	Chemical	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|response response|compound|END_ENTITY	Comparison of insulin response to intravenous glucose in healed myocardial_infarction , in `` cooled-off '' unstable and stable_angina_pectoris , and in healthy subjects .
10644551	0	glucose	90,97	insulin	48,55	glucose	insulin	MESH:D005947	3630	Chemical	Gene	infusions|compound|START_ENTITY pulsatile|nmod|infusions pulsatile|dobj|secretion secretion|compound|END_ENTITY	Concordant induction of rapid in vivo pulsatile insulin secretion by recurrent punctuated glucose infusions .
10710341	0	glucose	66,73	insulin	44,51	glucose	insulin	MESH:D005947	3630	Chemical	Gene	extraction|compound|START_ENTITY Comparison|nmod|extraction Comparison|nmod|END_ENTITY	Comparison of local and systemic effects of insulin on myocardial glucose extraction in ischemic_heart_disease .
10711659	0	glucose	156,163	insulin	165,172	glucose	insulin	MESH:D005947	3630	Chemical	Gene	lipid|compound|START_ENTITY lipid|dep|END_ENTITY	Breast milk leptin concentrations in initial and terminal milk samples : relationships to maternal and infant plasma leptin concentrations , adiposity , serum glucose , insulin , lipid and lipoprotein levels .
10781386	0	glucose	39,46	insulin	76,83	glucose	insulin	MESH:D005947	105613195	Chemical	Gene	homoeostasis|compound|START_ENTITY programming|nmod|homoeostasis timing|nmod|programming sensitivity|nsubj|timing sensitivity|nmod|pressure pressure|compound|END_ENTITY	Differential timing for programming of glucose homoeostasis , sensitivity to insulin and blood pressure by in utero exposure to dexamethasone in sheep .
10801929	0	glucose	45,52	insulin	107,114	glucose	insulin	MESH:D005947	397415(Tax:9823)	Chemical	Gene	tolerance|compound|START_ENTITY improves|dobj|tolerance improves|advcl|decreasing decreasing|dobj|extraction extraction|nmod|END_ENTITY	High chromium yeast supplementation improves glucose tolerance in pigs by decreasing hepatic extraction of insulin .
10857969	0	glucose	49,56	insulin	94,101	glucose	insulin	MESH:D005947	3630	Chemical	Gene	technique|compound|START_ENTITY mirrors|dobj|technique mirrors|nmod|assessment assessment|nmod|sensitivity sensitivity|compound|END_ENTITY	Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity : studies in subjects with various degrees of glucose_tolerance and insulin sensitivity .
10868826	0	glucose	110,117	insulin	52,59	glucose	insulin	MESH:D005947	3630	Chemical	Gene	disposal|compound|START_ENTITY Relationship|nmod|disposal Relationship|nmod|resistance resistance|compound|END_ENTITY	Relationship between several surrogate estimates of insulin resistance and quantification of insulin-mediated glucose disposal in 490 healthy nondiabetic volunteers .
10868944	0	glucose	99,106	insulin	45,52	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY regulate|dobj|metabolism Effects|acl|regulate Effects|nmod|diabetes diabetes|nmod|ability ability|nmod|END_ENTITY	Effects of type 2 diabetes on the ability of insulin and glucose to regulate splanchnic and muscle glucose metabolism : evidence for a defect in hepatic glucokinase activity .
10873662	0	glucose	101,108	insulin	76,83	glucose	insulin	MESH:D005947	3630	Chemical	Gene	level|compound|START_ENTITY decreases|dobj|level decreases|nsubj|administration administration|nmod|complex complex|acl|containing containing|dobj|vector vector|compound|END_ENTITY	Systemic administration of HVJ viral coat-liposome complex containing human insulin vector decreases glucose level in diabetic mouse : A model of gene therapy .
10898130	0	glucose	34,41	insulin	14,21	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY response|nmod|tolerance response|compound|END_ENTITY	Evaluation of insulin response in glucose tolerance test in a patient with Werner 's _ syndrome : a 16-year follow-up study .
10902801	0	glucose	76,83	insulin	27,34	glucose	insulin	MESH:D005947	3630	Chemical	Gene	effectiveness|compound|START_ENTITY errors|nmod|effectiveness insensitive|nmod|errors insensitive|nsubj|estimates estimates|nmod|sensitivity sensitivity|compound|END_ENTITY	Minimal-model estimates of insulin sensitivity are insensitive to errors in glucose effectiveness .
10909962	0	glucose	24,31	insulin	42,49	glucose	insulin	MESH:D005947	3630	Chemical	Gene	uptake|compound|START_ENTITY stimulation|nmod|uptake Enhanced|dobj|stimulation Enhanced|nmod|END_ENTITY	Enhanced stimulation of glucose uptake by insulin increases exercise-stimulated glucose uptake in skeletal muscle in humans : studies using -LSB- 15O -RSB- O2 , -LSB- 15O -RSB- H2O , -LSB- 18F -RSB- fluoro-deoxy-glucose , and positron emission tomography .
10909962	0	glucose	80,87	insulin	42,49	glucose	insulin	MESH:D005947	3630	Chemical	Gene	uptake|compound|START_ENTITY increases|dobj|uptake Enhanced|dep|increases Enhanced|nmod|END_ENTITY	Enhanced stimulation of glucose uptake by insulin increases exercise-stimulated glucose uptake in skeletal muscle in humans : studies using -LSB- 15O -RSB- O2 , -LSB- 15O -RSB- H2O , -LSB- 18F -RSB- fluoro-deoxy-glucose , and positron emission tomography .
10923634	0	glucose	32,39	insulin	87,94	glucose	insulin	MESH:D005947	3630	Chemical	Gene	excursions|compound|START_ENTITY Failure|nmod|excursions Failure|acl|entrain entrain|dobj|secretion secretion|compound|END_ENTITY	Failure of physiological plasma glucose excursions to entrain high-frequency pulsatile insulin secretion in type 2 diabetes .
10950832	0	glucose	57,64	insulin	102,109	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	production|compound|START_ENTITY production|nmod|changes changes|nmod|END_ENTITY	Inhibition of lipolysis causes suppression of endogenous glucose production independent of changes in insulin .
1100459	0	glucose	43,50	insulin	25,32	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of intracisternal insulin on plasma glucose and insulin in the dog .
11079746	0	glucose	120,127	insulin	10,17	glucose	insulin	MESH:D005947	3630	Chemical	Gene	transport|compound|START_ENTITY implications|nmod|transport treatment|dep|implications treatment|compound|END_ENTITY	Long-term insulin treatment of 3T3-L1 adipocytes results in mis-targeting of GLUT4 : implications for insulin-stimulated glucose transport .
11095452	0	glucose	71,78	insulin	10,17	glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY level|nmod|control Effect|nmod|level Effect|nmod|therapy therapy|compound|END_ENTITY	Effect of insulin and sulfonylurea therapy , at the same level of blood glucose control , on low density lipoprotein subfractions in type 2 diabetic patients .
11110411	0	glucose	59,66	insulin	37,44	glucose	insulin	MESH:D005947	3630	Chemical	Gene	promoter|amod|START_ENTITY production|nmod|promoter production|compound|END_ENTITY	Glucose-stimulated and self-limiting insulin production by glucose 6-phosphatase promoter driven insulin expression in hepatoma cells .
11110411	0	glucose	59,66	insulin	97,104	glucose	insulin	MESH:D005947	3630	Chemical	Gene	promoter|amod|START_ENTITY production|nmod|promoter driven|nsubj|production driven|dobj|expression expression|compound|END_ENTITY	Glucose-stimulated and self-limiting insulin production by glucose 6-phosphatase promoter driven insulin expression in hepatoma cells .
11131100	0	glucose	70,77	insulin	25,32	glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY management|nmod|control END_ENTITY|nmod|management	Insulin aspart vs. human insulin in the management of long-term blood glucose control in Type_1_diabetes_mellitus : a randomized controlled trial .
11139769	0	glucose	69,76	insulin	47,54	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	metabolism|compound|START_ENTITY regulating|dobj|metabolism END_ENTITY|acl|regulating	Low-dose IGF-I has no selective advantage over insulin in regulating glucose metabolism in hyperglycemic depancreatized dogs .
1114890	0	glucose	74,81	insulin	25,32	glucose	insulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY Blood|nmod|test Blood|dobj|END_ENTITY	Blood glucose and plasma insulin and glucagon response during intravenous glucose tolerance test in newborn infants affected by erythroblastosis_foetalis .
11159768	0	glucose	27,34	insulin	90,97	glucose	insulin	MESH:D005947	3630	Chemical	Gene	meters|compound|START_ENTITY specifications|nmod|meters specifications|dep|assessment assessment|nmod|modeling modeling|nmod|errors errors|nmod|dose dose|compound|END_ENTITY	Quality specifications for glucose meters : assessment by simulation modeling of errors in insulin dose .
1116652	0	glucose	10,17	insulin	29,36	glucose	insulin	MESH:D005947	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|acl|priming priming|nmod|response response|compound|END_ENTITY	Effect of glucose priming on insulin response in the premature infant .
11172480	0	glucose	151,158	insulin	99,106	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY range|nmod|tolerance phospholipid|nmod|range phospholipid|nmod|markers markers|nmod|resistance resistance|compound|END_ENTITY	Relationship of dietary fat and serum cholesterol_ester and phospholipid fatty_acids to markers of insulin resistance in men and women with a range of glucose tolerance .
11181869	0	glucose	27,34	insulin	45,52	glucose	insulin	MESH:D005947	3630	Chemical	Gene	response|nmod|START_ENTITY potassium|nsubj|response potassium|dobj|therapy therapy|compound|END_ENTITY	Blood pressure response to glucose potassium insulin therapy in patients with acute_stroke with mild to moderate hyperglycaemia .
11189235	0	glucose	82,89	insulin	22,29	glucose	insulin	MESH:D005947	3630	Chemical	Gene	Construction|nmod|START_ENTITY Construction|nmod|recombinant recombinant|compound|END_ENTITY	Construction of human insulin gene expression recombinant and its effect on blood glucose of diabetic rats .
11200947	0	glucose	43,50	insulin	20,27	glucose	insulin	MESH:D005947	3630	Chemical	Gene	load|compound|START_ENTITY response|nmod|load response|compound|END_ENTITY	Impairment of early insulin response after glucose load , rather than insulin resistance , is responsible for postprandial hyperglycemia seen in obese_type_2_diabetes : assessment using nateglinide , a new insulin secretagogue .
11200947	0	glucose	43,50	insulin	202,209	glucose	insulin	MESH:D005947	3630	Chemical	Gene	load|compound|START_ENTITY response|nmod|load Impairment|nmod|response responsible|nsubj|Impairment responsible|nmod|hyperglycemia hyperglycemia|acl|seen seen|nmod|obese_type_2_diabetes obese_type_2_diabetes|dep|nateglinide nateglinide|appos|secretagogue secretagogue|compound|END_ENTITY	Impairment of early insulin response after glucose load , rather than insulin resistance , is responsible for postprandial hyperglycemia seen in obese_type_2_diabetes : assessment using nateglinide , a new insulin secretagogue .
11201820	0	glucose	74,81	insulin	34,41	glucose	insulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY END_ENTITY|nmod|test	-LSB- Dynamics of changes in levels of insulin , glucagon , and C-peptide during glucose tolerance test in patients with coronary_atherosclerosis -RSB- .
11226623	0	glucose	54,61	insulin	9,16	glucose	insulin	MESH:D005947	3630	Chemical	Gene	administration|compound|START_ENTITY responses|nmod|administration kinetics|dep|responses kinetics|compound|END_ENTITY	Modeling insulin kinetics : responses to a single oral glucose administration or ambulatory-fed conditions .
1122924	0	glucose	95,102	insulin	11,18	glucose	insulin	MESH:D005947	3630	Chemical	Gene	infusions|nmod|START_ENTITY immunoreactivity|nmod|infusions immunoreactivity|nsubj|Changes Changes|nmod|END_ENTITY	Changes in insulin immunoreactivity across the coronary circulation in man during infusions of glucose and a fat emulsion .
1127073	0	glucose	66,73	insulin	4,11	glucose	insulin	MESH:D005947	3630	Chemical	Gene	levels|compound|START_ENTITY response|nmod|levels response|compound|END_ENTITY	The insulin response to intravenous fructose in relation to blood glucose levels .
11273248	0	glucose	36,43	insulin	50,57	glucose	insulin	MESH:D005947	3630	Chemical	Gene	Estimation|nmod|START_ENTITY serum|nsubj|Estimation serum|dobj|levels levels|compound|END_ENTITY	Estimation of fasting and post oral glucose serum insulin levels in hypertensive and obese subjects .
11288031	0	glucose	22,29	insulin	11,18	glucose	insulin	MESH:D005947	3630	Chemical	Gene	uptake|compound|START_ENTITY Effects|nmod|uptake Effects|nmod|END_ENTITY	Effects of insulin on glucose uptake and leg blood flow in patients with sickle cell disease and normal subjects .
11318824	0	glucose	68,75	insulin	20,27	glucose	insulin	MESH:D005947	3630	Chemical	Gene	meal|compound|START_ENTITY Renal|nmod|meal Renal|dobj|extraction extraction|nmod|END_ENTITY	Renal extraction of insulin and C-peptide in man before and after a glucose meal .
1135175	0	glucose	95,102	insulin	39,46	glucose	insulin	MESH:D005947	3630	Chemical	Gene	-RSB-|compound|START_ENTITY undergoing|dobj|-RSB- women|acl|undergoing immunoreactive|nmod|women immunoreactive|dobj|levels levels|compound|END_ENTITY	-LSB- Blood sugar and plasma immunoreactive insulin levels in healthy pregnant women undergoing the glucose tolerance test -RSB- .
1136855	0	glucose	65,72	insulin	25,32	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tests|compound|START_ENTITY Portal|nmod|tests Portal|dobj|END_ENTITY	Portal and cubital serum insulin during oral , portal and cubital glucose tolerance tests .
11380592	0	glucose	49,56	insulin	94,101	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY function|nmod|tolerance Assessment|nmod|function test|nsubj|Assessment test|nmod|model model|nmod|secretion secretion|compound|END_ENTITY	Assessment of beta-cell function during the oral glucose tolerance test by a minimal model of insulin secretion .
11412137	0	glucose	49,56	insulin	79,86	glucose	insulin	MESH:D005947	3630	Chemical	Gene	uptake|compound|START_ENTITY mechanisms|nmod|uptake mechanisms|nmod|END_ENTITY	Intracellular mechanisms underlying increases in glucose uptake in response to insulin or exercise in skeletal muscle .
1143049	0	glucose	47,54	insulin	12,19	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	turnover|compound|START_ENTITY regulating|dobj|turnover END_ENTITY|acl|regulating	The role of insulin and glucagon in regulating glucose turnover in dogs during exercise .
11447730	0	glucose	41,48	insulin	92,99	glucose	insulin	MESH:D005947	3630	Chemical	Gene	Simplification|nmod|START_ENTITY Simplification|nmod|resistance resistance|compound|END_ENTITY	Simplification of continuous infusion of glucose with model assessment in the evaluation of insulin resistance in women with PCOS .
11472274	0	glucose	112,119	insulin	57,64	glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY improve|dobj|control improve|nsubj|restoration restoration|nmod|secretion secretion|compound|END_ENTITY	Rapid acting insulinotropic agents : restoration of early insulin secretion as a physiologic approach to improve glucose control .
11473051	0	glucose	43,50	insulin	19,26	glucose	insulin	MESH:D005947	3630	Chemical	Gene	production|compound|START_ENTITY inhibit|dobj|production inhibit|nsubj|increases increases|nmod|END_ENTITY	Small increases in insulin inhibit hepatic glucose production solely caused by an effect on glycogen metabolism .
11473051	3	glucose	657,664	insulin	595,602	glucose	insulin	MESH:D005947	3630	Chemical	Gene	infusion|compound|START_ENTITY maintained|nmod|infusion euglycemia|acl|maintained induced|nmod|euglycemia induced|nsubjpass|increase increase|nmod|END_ENTITY	A 40-min basal period was followed by a 180-min experimental period in which an increase in insulin was induced , with euglycemia maintained by peripheral glucose infusion .
11478588	0	glucose	77,84	insulin	35,42	glucose	insulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY elevates|nmod|test elevates|dobj|response response|compound|END_ENTITY	Caffeine ingestion elevates plasma insulin response in humans during an oral glucose tolerance test .
11481397	3	glucose	575,582	insulin	471,478	glucose	insulin	MESH:D005947	3630	Chemical	Gene	levels|compound|START_ENTITY secrete|nmod|levels respond|xcomp|secrete respond|nmod|doses doses|nmod|END_ENTITY	Two important characteristics of this disease are insulin resistance , the failure of peripheral tissues , including liver , muscle , and adipose tissue , to respond to physiologic doses of insulin , and failure of pancreatic beta-cells to properly secrete insulin in response to elevated blood glucose levels .
11484512	0	glucose	69,76	insulin	18,25	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY affects|dobj|metabolism insights|dep|affects insights|nmod|pathophysiology pathophysiology|compound|END_ENTITY	New insights into insulin resistance pathophysiology : how it affects glucose and lipid metabolism .
11485378	0	glucose	62,69	insulin	101,108	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	tolerance|compound|START_ENTITY administration|nmod|tolerance Effects|nmod|administration Effects|nmod|END_ENTITY	Effects of S-nitroso-N-acetyl-penicillamine administration on glucose tolerance and plasma levels of insulin and glucagon in the dog .
1149774	0	glucose	109,116	insulin	94,101	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	infusions|compound|START_ENTITY physiological|nmod|infusions physiological|dobj|increments increments|nmod|END_ENTITY	Hepatic balances of glucose and insulin in response to physiological increments of endogenous insulin during glucose infusions in dogs .
1149774	0	glucose	20,27	insulin	94,101	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	balances|nmod|START_ENTITY balances|xcomp|physiological physiological|dobj|increments increments|nmod|END_ENTITY	Hepatic balances of glucose and insulin in response to physiological increments of endogenous insulin during glucose infusions in dogs .
1149952	0	glucose	19,26	insulin	39,46	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	infusion|compound|START_ENTITY Effect|nmod|infusion Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of cephalic glucose infusion on insulin secretion .
11522673	0	glucose	25,32	insulin	82,89	glucose	insulin	MESH:D005947	3630	Chemical	Gene	Interactions|nmod|START_ENTITY Interactions|dep|transport transport|nmod|resistance resistance|compound|END_ENTITY	Interactions of impaired glucose transport and phosphorylation in skeletal muscle insulin resistance : a dose-response assessment using positron emission tomography .
115730	0	glucose	84,91	insulin	45,52	glucose	insulin	MESH:D005947	3630	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|treatment treatment|nmod|responses responses|compound|END_ENTITY	The effect of glibenclamide treatment on the insulin and glucagon responses to oral glucose and galactose in maturity onset diabetics .
11574295	0	glucose	54,61	insulin	74,81	glucose	insulin	MESH:D005947	3630	Chemical	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	Profiles of growth_hormone and insulin secretion , and glucose response to insulin in growing Japanese Black heifers -LRB- beef type -RRB- : comparison with Holstein heifers -LRB- dairy type -RRB- .
11574399	0	glucose	42,49	insulin	14,21	glucose	insulin	MESH:D005947	3630	Chemical	Gene	concentrations|compound|START_ENTITY effect|nmod|concentrations effect|nmod|END_ENTITY	The effect of insulin on in vivo cerebral glucose concentrations and rates of glucose transport/metabolism in humans .
11574399	0	glucose	78,85	insulin	14,21	glucose	insulin	MESH:D005947	3630	Chemical	Gene	transport/metabolism|compound|START_ENTITY effect|nmod|transport/metabolism effect|nmod|END_ENTITY	The effect of insulin on in vivo cerebral glucose concentrations and rates of glucose transport/metabolism in humans .
11589968	0	glucose	91,98	insulin	78,85	glucose	insulin	MESH:D005947	3630	Chemical	Gene	simulation|nmod|START_ENTITY simulation|dobj|studies studies|nmod|interaction interaction|nmod|END_ENTITY	Spectroscopic and molecular dynamics simulation studies of the interaction of insulin with glucose .
1159064	0	glucose	92,99	insulin	35,42	glucose	insulin	MESH:D005947	3630	Chemical	Gene	concentration|compound|START_ENTITY duplication|nmod|concentration model|nmod|duplication effect|dep|model effect|nmod|prednisone prednisone|nmod|secretion secretion|compound|END_ENTITY	Inhibitory effect of prednisone on insulin secretion in man : model for duplication of blood glucose concentration .
11596673	0	glucose	154,161	insulin	128,135	glucose	insulin	MESH:D005947	3630	Chemical	Gene	caucasians|compound|START_ENTITY Studies|nmod|caucasians Studies|nmod|relation relation|nmod|sensitivity sensitivity|compound|END_ENTITY	Studies of the Pro12Ala polymorphism of the peroxisome_proliferator-activated_receptor-gamma2 -LRB- PPAR-gamma2 -RRB- gene in relation to insulin sensitivity among glucose tolerant caucasians .
11600513	0	glucose	8,15	insulin	16,23	glucose	insulin	MESH:D005947	3630	Chemical	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Fasting glucose insulin ratio : a useful measure of insulin resistance in girls with premature_adrenarche .
11600513	0	glucose	8,15	insulin	51,58	glucose	insulin	MESH:D005947	3630	Chemical	Gene	ratio|compound|START_ENTITY ratio|dep|measure measure|nmod|resistance resistance|compound|END_ENTITY	Fasting glucose insulin ratio : a useful measure of insulin resistance in girls with premature_adrenarche .
1165235	0	glucose	34,41	insulin	62,69	glucose	insulin	MESH:D005947	3630	Chemical	Gene	action|compound|START_ENTITY action|nmod|END_ENTITY	Time course of termination of the glucose transport action of insulin in adipocytes .
11686635	0	glucose	46,53	insulin	15,22	glucose	insulin	MESH:D005947	3630	Chemical	Gene	stimulus|compound|START_ENTITY rate|nmod|stimulus rate|compound|END_ENTITY	Reconstructing insulin secretion rate after a glucose stimulus by an improved stochastic deconvolution method .
1171746	0	glucose	56,63	insulin	15,22	glucose	insulin	MESH:D005947	3630	Chemical	Gene	arginine|compound|START_ENTITY Comparison|nmod|arginine Comparison|nmod|reactions reactions|compound|END_ENTITY	-LSB- Comparison of insulin reactions in various diseases to glucose , arginine , and glucagon -RSB- .
1172239	0	glucose	88,95	insulin	48,55	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	load|compound|START_ENTITY Dynamics|nmod|load Dynamics|nmod|secretion secretion|compound|END_ENTITY	Dynamics of canine pancreatic blood flow and of insulin secretion during an intravenous glucose load .
1173504	0	glucose	35,42	insulin	16,23	glucose	insulin	MESH:D005947	3630	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|Potentiation Potentiation|nmod|END_ENTITY	Potentiation of insulin release by glucose in man .
1173504	1	glucose	153,160	insulin	114,121	glucose	insulin	MESH:D005947	3630	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|analysis analysis|nmod|enhancement enhancement|nmod|END_ENTITY	I. Quantitative analysis of the enhancement of glucose-induced insulin secretion by pretreatment with glucose in normal subjects .
11739446	0	glucose	59,66	insulin	26,33	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY secretion|nmod|tolerance secretion|nsubj|Importance Importance|nmod|END_ENTITY	Importance of early phase insulin secretion to intravenous glucose tolerance in subjects with type_2_diabetes_mellitus .
11749779	0	glucose	52,59	insulin	33,40	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY actions|nmod|metabolism actions|compound|END_ENTITY	B9-serine residue is crucial for insulin actions in glucose metabolism .
1175535	0	glucose	51,58	insulin	18,25	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	administration|compound|START_ENTITY secretion|nmod|administration secretion|compound|END_ENTITY	-LSB- The mechanism of insulin secretion following oral glucose administration .
11782867	0	glucose	15,22	insulin	90,97	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY Improvement|nmod|tolerance occurs|nsubj|Improvement occurs|nmod|enhancement enhancement|nmod|secretion secretion|compound|END_ENTITY	Improvement of glucose tolerance by nateglinide occurs through enhancement of early phase insulin secretion .
11782882	0	glucose	129,136	insulin	25,32	glucose	insulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY plasma|nmod|test function|xcomp|plasma function|nsubj|contribution contribution|nmod|sensitivity sensitivity|compound|END_ENTITY	Relative contribution of insulin sensitivity and beta-cell function to plasma glucose and insulin concentrations during the oral glucose tolerance test .
11782882	0	glucose	78,85	insulin	25,32	glucose	insulin	MESH:D005947	3630	Chemical	Gene	concentrations|compound|START_ENTITY plasma|dobj|concentrations function|xcomp|plasma function|nsubj|contribution contribution|nmod|sensitivity sensitivity|compound|END_ENTITY	Relative contribution of insulin sensitivity and beta-cell function to plasma glucose and insulin concentrations during the oral glucose tolerance test .
11798560	0	glucose	70,77	insulin	15,22	glucose	insulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY rate|nmod|test rate|compound|END_ENTITY	-LSB- Estimation of insulin secretion rate in multiple sampled intravenous glucose tolerance test -RSB- .
1182245	0	glucose	6,13	insulin	21,28	glucose	insulin	MESH:D005947	3630	Chemical	Gene	serum|nsubj|START_ENTITY serum|dobj|response response|compound|END_ENTITY	Blood glucose , serum insulin and glucagon response to arginine in premature infants .
11850099	0	glucose	77,84	insulin	39,46	glucose	insulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY assess|advcl|test assess|dobj|sensitivity sensitivity|compound|END_ENTITY	Validation of simple indices to assess insulin sensitivity based on the oral glucose tolerance test in the Japanese population .
11854636	0	glucose	53,60	insulin	5,12	glucose	insulin	MESH:D005947	3630	Chemical	Gene	gestational_diabetes_mellitus|compound|START_ENTITY patients|nmod|gestational_diabetes_mellitus secretion|nmod|patients secretion|nsubj|END_ENTITY	Does insulin secretion in patients with one abnormal glucose tolerance test value mimic gestational_diabetes_mellitus ?
11860817	0	glucose	54,61	insulin	71,78	glucose	insulin	MESH:D005947	3630	Chemical	Gene	fasting|dobj|START_ENTITY -LSB-|dep|fasting -LSB-|dep|fasting fasting|dobj|hormones hormones|compound|END_ENTITY	-LSB- A case control study on the levels of lipid , fasting glucose , fasting insulin and sex hormones of hypertension in among elderly Uighur people in Hetian , Xinjiang -RSB- .
11872677	0	glucose	79,86	insulin	28,35	glucose	insulin	MESH:D005947	3630	Chemical	Gene	uptake|compound|START_ENTITY stimulate|dobj|uptake deter|advcl|stimulate deter|nsubj|binding binding|nmod|END_ENTITY	Albumin binding of acylated insulin -LRB- NN304 -RRB- does not deter action to stimulate glucose uptake .
1189493	0	glucose	99,106	insulin	24,31	glucose	insulin	MESH:D005947	3630	Chemical	Gene	-RSB-|compound|START_ENTITY subjects|nmod|-RSB- Study|nmod|subjects Study|nmod|effect effect|nmod|END_ENTITY	-LSB- Study on the effect of insulin on carbohydrate and lipid metabolism in obese subjects with normal glucose tolerance -RSB- .
11899846	0	glucose	15,22	insulin	24,31	glucose	insulin	MESH:D005947	3630	Chemical	Gene	C-peptide|compound|START_ENTITY C-peptide|dep|END_ENTITY	-LSB- Evaluation of glucose , insulin , C-peptide uric_acid serum levels in patients with psoriasis -RSB- .
11932032	0	glucose	160,167	insulin	102,109	glucose	insulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY modified|dobj|test insulin|acl|modified derive|nmod|insulin derive|dobj|estimates estimates|nmod|sensitivity sensitivity|compound|END_ENTITY	Insulin sensitivity in type 2 diabetes : univariate and multivariate techniques to derive estimates of insulin sensitivity from the insulin modified intravenous glucose tolerance test -LRB- FSIGT -RRB- .
11932032	0	glucose	160,167	insulin	131,138	glucose	insulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY modified|dobj|test END_ENTITY|acl|modified	Insulin sensitivity in type 2 diabetes : univariate and multivariate techniques to derive estimates of insulin sensitivity from the insulin modified intravenous glucose tolerance test -LRB- FSIGT -RRB- .
11932320	0	glucose	150,157	insulin	70,77	glucose	insulin	MESH:D005947	3630	Chemical	Gene	comparison|nmod|START_ENTITY comparison|nmod|cholecystokinin cholecystokinin|dep|END_ENTITY	A comparison of the effects of pegvisomant and octreotide on glucose , insulin , gastrin , cholecystokinin , and pancreatic_polypeptide responses to oral glucose and a standard mixed meal .
11932320	0	glucose	61,68	insulin	70,77	glucose	insulin	MESH:D005947	3630	Chemical	Gene	cholecystokinin|compound|START_ENTITY cholecystokinin|dep|END_ENTITY	A comparison of the effects of pegvisomant and octreotide on glucose , insulin , gastrin , cholecystokinin , and pancreatic_polypeptide responses to oral glucose and a standard mixed meal .
1193311	0	glucose	46,53	insulin	21,28	glucose	insulin	MESH:D005947	3630	Chemical	Gene	load|compound|START_ENTITY Relationship|nmod|load Relationship|nmod|response response|compound|END_ENTITY	Relationship between insulin response to oral glucose load and creatinine clearance .
1193312	0	glucose	92,99	insulin	60,67	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	carbohydrate|nmod|START_ENTITY carbohydrate|nmod|response response|compound|END_ENTITY	Influence of antecedent carbohydrate intake on the biphasic insulin response to intravenous glucose .
11943004	0	glucose	14,21	insulin	65,72	glucose	insulin	MESH:D005947	3630	Chemical	Gene	excursions|compound|START_ENTITY excursions|nmod|methods methods|nmod|administration administration|compound|END_ENTITY	Post-prandial glucose excursions following four methods of bolus insulin administration in subjects with type 1 diabetes .
12002173	0	glucose	9,16	insulin	46,53	glucose	insulin	MESH:D005947	3630	Chemical	Gene	model|compound|START_ENTITY model|dep|estimation estimation|nmod|sensitivity sensitivity|compound|END_ENTITY	The oral glucose minimal model : estimation of insulin sensitivity from a meal test .
12011082	0	glucose	11,18	insulin	30,37	glucose	insulin	MESH:D005947	280829(Tax:9913)	Chemical	Gene	Effects|nmod|START_ENTITY exogenous|nsubj|Effects exogenous|dobj|END_ENTITY	Effects of glucose , exogenous insulin , and carbachol on C-peptide and insulin secretion from isolated perifused rat islets .
12031951	0	glucose	42,49	insulin	31,38	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	uptake|compound|START_ENTITY effects|nmod|uptake effects|nmod|END_ENTITY	Direct and indirect effects of insulin on glucose uptake and storage by the liver .
12079869	0	glucose	45,52	insulin	75,82	glucose	insulin	MESH:D005947	3630	Chemical	Gene	fasting|dobj|START_ENTITY fasting|advcl|fasting fasting|dobj|levels levels|compound|END_ENTITY	High-fat high-energy feeding impairs fasting glucose and increases fasting insulin levels in the G ttingen minipig : results from a pilot study .
12099959	0	glucose	110,117	insulin	20,27	glucose	insulin	MESH:D005947	3630	Chemical	Gene	fasting|dobj|START_ENTITY elevated|xcomp|fasting elevated|nsubj|Diminution Diminution|nmod|response response|compound|END_ENTITY	Diminution of early insulin response to glucose in subjects with normal but minimally elevated fasting plasma glucose .
12099959	0	glucose	40,47	insulin	20,27	glucose	insulin	MESH:D005947	3630	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Diminution of early insulin response to glucose in subjects with normal but minimally elevated fasting plasma glucose .
12110541	0	glucose	74,81	insulin	35,42	glucose	insulin	MESH:D005947	3630	Chemical	Gene	uptake|compound|START_ENTITY augments|dobj|uptake augments|nsubj|resistance resistance|compound|END_ENTITY	Free fatty_acid-induced peripheral insulin resistance augments splanchnic glucose uptake in healthy humans .
12153361	0	glucose	43,50	insulin	32,39	glucose	insulin	MESH:D005947	100009181(Tax:9986)	Chemical	Gene	levels|compound|START_ENTITY END_ENTITY|nmod|levels	Effects of oropharyngeal/buccal insulin on glucose levels in alloxan-induced diabetic rabbits : clinical implications .
12184210	0	glucose	80,87	insulin	35,42	glucose	insulin	MESH:D005947	3630	Chemical	Gene	transport|compound|START_ENTITY roles|nmod|transport roles|nmod|regulation regulation|amod|adenosine adenosine|nmod|END_ENTITY	The putative roles of adenosine in insulin - and exercise-mediated regulation of glucose transport and glycogen metabolism in skeletal muscle .
12189441	0	glucose	62,69	insulin	42,49	glucose	insulin	MESH:D005947	3630	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Defective amplification of the late phase insulin response to glucose by GIP in obese Type II diabetic patients .
1225247	0	glucose	34,41	insulin	7,14	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY levels|nmod|tolerance levels|compound|END_ENTITY	-LSB- Blood insulin levels during oral glucose tolerance tests in the obese child .
1234066	0	glucose	41,48	insulin	19,26	glucose	insulin	MESH:D005947	3630	Chemical	Gene	-RSB-|amod|START_ENTITY responders|nmod|-RSB- responders|nsubj|Proportion Proportion|nmod|END_ENTITY	-LSB- Proportion of low insulin responders to glucose among the offspring of maturity-onset diabetics -LRB- author 's transl -RRB- -RSB- .
12393900	0	glucose	87,94	insulin	65,72	glucose	insulin	MESH:D005947	3630	Chemical	Gene	transport|compound|START_ENTITY activation|nmod|transport activation|compound|END_ENTITY	Translocation of small preformed vesicles is responsible for the insulin activation of glucose transport in adipose cells .
12399273	0	glucose	81,88	insulin	48,55	glucose	insulin	MESH:D005947	3630	Chemical	Gene	disposal|compound|START_ENTITY concentration|nmod|disposal concentration|compound|END_ENTITY	Oral arginine does not stimulate an increase in insulin concentration but delays glucose disposal .
12416664	3	glucose	455,462	insulin	502,509	glucose	insulin	MESH:D005947	3630	Chemical	Gene	disappearance|compound|START_ENTITY accordance|nmod|disappearance accordance|acl|obtained obtained|nmod|test test|compound|END_ENTITY	In accordance with the constant for rate serum glucose disappearance -LRB- KITT -RRB- obtained from the insulin tolerance test , the subjects were divided into quartiles , considering as insulin-resistant individuals those in quartile 1 , and insulin-sensitive subjects those in quartile 4 .
12450355	0	glucose	41,48	insulin	21,28	glucose	insulin	MESH:D005947	3630	Chemical	Gene	Estimation|nmod|START_ENTITY Estimation|nmod|END_ENTITY	Estimation of plasma insulin from plasma glucose .
12453890	0	glucose	35,42	insulin	12,19	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	The role of insulin in human brain glucose metabolism : an 18fluoro-deoxyglucose positron emission tomography study .
12456717	0	glucose	173,180	insulin	126,133	glucose	insulin	MESH:D005947	3630	Chemical	Gene	uptake|compound|START_ENTITY augments|dobj|uptake END_ENTITY|acl:relcl|augments	An insulin-related peptide expressed in 3T3L1 adipocytes is localized in GLUT4 vesicles and secreted in response to exogenous insulin , which augments the insulin-stimulated glucose uptake .
12472919	0	glucose	35,42	insulin	108,115	glucose	insulin	MESH:D005947	3630	Chemical	Gene	uptake|compound|START_ENTITY improvement|nmod|uptake function|nsubj|improvement function|nmod|resistance resistance|compound|END_ENTITY	Bezafibrate-induced improvement in glucose uptake and endothelial function in protease inhibitor-associated insulin resistance .
12518254	6	glucose	832,839	insulin	798,805	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	mg|compound|START_ENTITY surgery|dobj|mg resistant|advcl|surgery resistant|advmod|END_ENTITY	RESULTS : The patient was insulin resistant before surgery -LRB- glucose infusion 4.6 mg .
12594693	0	glucose	43,50	insulin	23,30	glucose	insulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY END_ENTITY|nmod|test	Increased secretion of insulin during oral glucose tolerance test can be a predictor of stent restenosis in nondiabetic patients .
12635907	0	glucose	117,124	insulin	97,104	glucose	insulin	MESH:D005947	105613195	Chemical	Gene	challenge|compound|START_ENTITY fit|nmod|challenge fit|nmod|modelling modelling|nmod|response response|compound|END_ENTITY	Uising WinBUGS to fit nonlinear mixed models with an application to pharmacokinetic modelling of insulin response to glucose challenge in sheep exposed antenatally to glucocorticoids .
12652355	0	glucose	98,105	insulin	39,46	glucose	insulin	MESH:D005947	102133184	Chemical	Gene	excursions|compound|START_ENTITY controls|dobj|excursions controls|nsubj|restoration restoration|nmod|response response|compound|END_ENTITY	Pharmacologic restoration of the early insulin response in pre-diabetic monkeys controls mealtime glucose excursions without peripheral_hyperinsulinaemia .
12716784	0	glucose	37,44	insulin	94,101	glucose	insulin	MESH:D005947	3630	Chemical	Gene	significance|nmod|START_ENTITY significance|dep|importance importance|nmod|secretion secretion|compound|END_ENTITY	The significance of impaired fasting glucose versus impaired_glucose_tolerance : importance of insulin secretion and resistance .
1273492	0	glucose	48,55	insulin	16,23	glucose	insulin	MESH:D005947	3630	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	The early serum insulin response to intravenous glucose in patients with decreased_glucose_tolerance and in subjects with a familial history of diabetes_mellitus .
12746632	0	glucose	102,109	insulin	23,30	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY secretion|nmod|tolerance secretion|nsubj|Effect Effect|nmod|metformin metformin|nmod|sensitivity sensitivity|compound|END_ENTITY	Effect of metformin on insulin sensitivity and insulin secretion in female obese patients with normal glucose tolerance .
12759893	0	glucose	93,100	insulin	50,57	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY subjects|nmod|tolerance resistance|nmod|subjects resistance|compound|END_ENTITY	Hypertriglyceridemia is associated with increased insulin resistance in subjects with normal glucose tolerance : evaluation in a large cohort of subjects assessed with the 1999 World Health Organization criteria for the classification of diabetes .
12762965	0	glucose	99,106	insulin	81,88	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY action|nmod|metabolism action|compound|END_ENTITY	Insulin-mediated capillary recruitment in skeletal muscle : is this a mediator of insulin action on glucose metabolism ?
1278455	0	glucose	55,62	insulin	89,96	glucose	insulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY test|nmod|levels levels|compound|END_ENTITY	The effect of D-norgestrel , 30 micrograms , on the oral glucose tolerance test , including insulin levels , in Thai women .
1278604	0	glucose	76,83	insulin	31,38	glucose	insulin	MESH:D005947	3630	Chemical	Gene	response|nmod|START_ENTITY END_ENTITY|dep|response	Human maternal and fetal serum insulin and growth hormone -LRB- HGH -RRB- response to glucose and leucine .
12829641	0	glucose	50,57	insulin	100,107	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY deterioration|nmod|tolerance Mechanisms|nmod|deterioration Mechanisms|dep|contribution contribution|nmod|alterations alterations|nmod|secretion secretion|compound|END_ENTITY	Mechanisms of the age-associated deterioration in glucose tolerance : contribution of alterations in insulin secretion , action , and clearance .
12879253	0	glucose	53,60	insulin	66,73	glucose	insulin	MESH:D005947	3630	Chemical	Gene	sensitivity|nmod|START_ENTITY role|nmod|sensitivity role|nmod|resistance resistance|compound|END_ENTITY	Predominant role of reduced beta-cell sensitivity to glucose over insulin resistance in impaired_glucose_tolerance .
12882859	0	glucose	163,170	insulin	76,83	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY subjects|nmod|tolerance obese|appos|subjects associated|nmod|obese associated|nmod|resistance resistance|compound|END_ENTITY	Increased visceral fat and serum levels of triglyceride are associated with insulin resistance in Japanese metabolically obese , normal weight subjects with normal glucose tolerance .
12882903	0	glucose	80,87	insulin	15,22	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	load|compound|START_ENTITY Interaction|nmod|load Interaction|nmod|exercise exercise|compound|END_ENTITY	Interaction of insulin and prior exercise in control of hepatic metabolism of a glucose load .
12906365	0	glucose	106,113	insulin	33,40	glucose	insulin	MESH:D005947	3630	Chemical	Gene	load|compound|START_ENTITY effect|nmod|load effect|nmod|sensitivity sensitivity|compound|END_ENTITY	The effect of surgical stress on insulin sensitivity , glucose effectiveness and acute insulin response to glucose load .
12915671	0	glucose	115,122	insulin	149,156	glucose	insulin	MESH:D005947	3630	Chemical	Gene	ability|nmod|START_ENTITY ability|acl|entrain entrain|dobj|END_ENTITY	Influence of rosiglitazone treatment on beta-cell function in type 2 diabetes : evidence of an increased ability of glucose to entrain high-frequency insulin pulsatility .
12943888	0	glucose	21,28	insulin	85,92	glucose	insulin	MESH:D005947	3630	Chemical	Gene	START_ENTITY|acl|identifying identifying|nmod|resistance resistance|compound|END_ENTITY	Usefulness of plasma glucose and insulin concentrations in identifying patients with insulin resistance .
1317827	0	glucose	31,38	insulin	14,21	glucose	insulin	MESH:D005947	3630	Chemical	Gene	disposal|compound|START_ENTITY mediated|dobj|disposal mediated|nsubj|Resistance Resistance|nmod|END_ENTITY	Resistance to insulin mediated glucose disposal in obese subjects : respective effect of lipid metabolism and glycemia .
1322137	0	glucose	38,45	insulin	11,18	glucose	insulin	MESH:D005947	3630	Chemical	Gene	Control|nmod|START_ENTITY Control|nmod|expression expression|compound|END_ENTITY	Control of insulin gene expression by glucose .
1330412	0	glucose	95,102	insulin	34,41	glucose	insulin	MESH:D005947	3630	Chemical	Gene	plasma|nmod|START_ENTITY plasma|dobj|concentrations concentrations|compound|END_ENTITY	Ageing and the response of plasma insulin , glucose and C-peptide concentrations to intravenous glucose in postmenopausal women .
1346936	0	glucose	52,59	insulin	8,15	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	metabolism|compound|START_ENTITY Role|nmod|metabolism Role|nmod|END_ENTITY	Role of insulin and glucagon in oxytocin effects on glucose metabolism .
1347143	0	glucose	14,21	insulin	53,60	glucose	insulin	MESH:D005947	3630	Chemical	Gene	Regulation|nmod|START_ENTITY kinetics|nsubj|Regulation kinetics|nmod|END_ENTITY	Regulation of glucose kinetics in trauma patients by insulin and glucagon .
13990877	0	glucose	56,63	insulin	11,18	glucose	insulin	MESH:D005947	105613195	Chemical	Gene	uptake|nmod|START_ENTITY END_ENTITY|nmod|uptake	-LSB- Action of insulin on the uptake and phosphorylation of glucose and fructose by sheep spermatazoids -RSB- .
1415425	0	glucose	38,45	insulin	80,87	glucose	insulin	MESH:D005947	3630	Chemical	Gene	START_ENTITY|nmod|infusion infusion|compound|END_ENTITY	Longitudinal changes in basal hepatic glucose production and suppression during insulin infusion in normal pregnant women .
143314	0	glucose	86,93	insulin	29,36	glucose	insulin	MESH:D005947	3630	Chemical	Gene	-RSB-|compound|START_ENTITY concentrations|nmod|-RSB- induced|nmod|concentrations induced|nsubj|Influence Influence|nmod|temperature temperature|nmod|secretion secretion|compound|END_ENTITY	-LSB- Influence of temperature on insulin secretion induced by different concentrations of glucose -RSB- .
1435293	0	glucose	123,130	insulin	45,52	glucose	insulin	MESH:D005947	3630	Chemical	Gene	concentrations|nmod|START_ENTITY concentrations|nsubj|relationship relationship|nmod|END_ENTITY	An apparently anomalous relationship between insulin and C-peptide concentrations in their initial response to intravenous glucose .
1436266	0	glucose	108,115	insulin	20,27	glucose	insulin	MESH:D005947	3630	Chemical	Gene	toxicity|compound|START_ENTITY concept|nmod|toxicity support|nmod|concept secretion|dep|support secretion|compound|END_ENTITY	Glucagon-stimulated insulin secretion in patients with type_2_diabetes_mellitus : support for the concept of glucose toxicity .
14506629	0	glucose	54,61	insulin	17,24	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY troglitazone|nmod|metabolism troglitazone|nsubj|impact impact|nmod|sensitizer sensitizer|compound|END_ENTITY	The impact of an insulin sensitizer , troglitazone , on glucose metabolism in African Americans at risk for type_2_diabetes_mellitus : a placebo-controlled , 24-month randomized study .
14510862	0	glucose	39,46	insulin	50,57	glucose	insulin	MESH:D005947	3630	Chemical	Gene	START_ENTITY|nmod|infusion infusion|compound|END_ENTITY	Does overnight normalization of plasma glucose by insulin infusion affect assessment of glucose metabolism in Type 2 diabetes ?
14510862	0	glucose	88,95	insulin	50,57	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY assessment|nmod|metabolism affect|dobj|assessment affect|nmod|glucose glucose|nmod|infusion infusion|compound|END_ENTITY	Does overnight normalization of plasma glucose by insulin infusion affect assessment of glucose metabolism in Type 2 diabetes ?
14524211	0	glucose	16,23	insulin	34,41	glucose	insulin	MESH:D005947	3630	Chemical	Gene	mean|nsubj|START_ENTITY mean|dobj|END_ENTITY	Does high blood glucose mean more insulin ?
14526271	0	glucose	53,60	insulin	32,39	glucose	insulin	MESH:D005947	3630	Chemical	Gene	levels|compound|START_ENTITY reduces|dobj|levels reduces|nsubj|expression expression|nmod|gene gene|compound|END_ENTITY	Hepatic expression of the human insulin gene reduces glucose levels in vivo in diabetic mice model .
14532169	0	glucose	47,54	insulin	91,98	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	uptake|compound|START_ENTITY infection|nmod|uptake Impact|nmod|infection Impact|dep|interaction interaction|nmod|END_ENTITY	Impact of infection on glucose-dependent liver glucose uptake during TPN : interaction with insulin .
14562192	0	glucose	10,17	insulin	18,25	glucose	insulin	MESH:D005947	3630	Chemical	Gene	infusion|compound|START_ENTITY infusion|compound|END_ENTITY	Long-term glucose insulin potassium infusion improves systolic and diastolic function in patients with chronic ischemic_cardiomyopathy .
1458877	6	glucose	991,998	insulin	887,894	glucose	insulin	MESH:D005947	280829(Tax:9913)	Chemical	Gene	challenge|compound|START_ENTITY had|nmod|challenge had|dobj|END_ENTITY	Age did not influence basal glucose concentrations -LRB- P > .10 -RRB- , but older calves had higher basal insulin -LRB- P < .0001 -RRB- and greater areas under the curves -LRB- P < .0005 -RRB- for both glucose and insulin after a glucose challenge .
1459914	0	glucose	72,79	insulin	109,116	glucose	insulin	MESH:D005947	105613195	Chemical	Gene	responsiveness|compound|START_ENTITY responsiveness|nmod|responsiveness responsiveness|nmod|END_ENTITY	Combined effects of diet and cold exposure on insulin responsiveness to glucose and tissue responsiveness to insulin in sheep .
1459914	0	glucose	72,79	insulin	46,53	glucose	insulin	MESH:D005947	105613195	Chemical	Gene	responsiveness|compound|START_ENTITY responsiveness|nmod|responsiveness responsiveness|nsubj|effects effects|nmod|exposure exposure|nmod|END_ENTITY	Combined effects of diet and cold exposure on insulin responsiveness to glucose and tissue responsiveness to insulin in sheep .
14633821	0	glucose	85,92	insulin	11,18	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY subjects|nmod|metabolism methods|nmod|subjects Diagnosing|nmod|methods Diagnosing|dobj|resistance resistance|compound|END_ENTITY	Diagnosing insulin resistance by simple quantitative methods in subjects with normal glucose metabolism .
14642866	0	glucose	40,47	insulin	10,17	glucose	insulin	MESH:D005947	3630	Chemical	Gene	up|nmod|START_ENTITY transport|advmod|up transport|nsubj|Effect Effect|nmod|END_ENTITY	Effect of insulin and contraction up on glucose transport in skeletal muscle .
14655846	0	glucose	65,72	insulin	22,29	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY clearance|nmod|metabolism levels|appos|clearance levels|appos|secretion secretion|compound|END_ENTITY	Plasma leptin levels , insulin secretion , clearance and action on glucose metabolism in anorexia_nervosa .
1468301	0	glucose	39,46	insulin	15,22	glucose	insulin	MESH:D005947	3630	Chemical	Gene	transport|compound|START_ENTITY Interaction|nmod|transport Interaction|nmod|END_ENTITY	Interaction of insulin and exercise on glucose transport in muscle .
14686965	0	glucose	88,95	insulin	26,33	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY subjects|nmod|tolerance resistance|nmod|subjects resistance|compound|END_ENTITY	The effect of acarbose on insulin resistance in obese hypertensive subjects with normal glucose tolerance : a randomized controlled study .
14703429	0	glucose	140,147	insulin	27,34	glucose	insulin	MESH:D005947	3630	Chemical	Gene	-RSB-|compound|START_ENTITY patients|nmod|-RSB- beta-cells|nmod|patients resistance|nmod|beta-cells resistance|compound|END_ENTITY	-LSB- A study of the degrees of insulin resistance and first-phase insulin secretion of beta-cells in metabolic_syndrome patients with different glucose tolerance -RSB- .
14709197	0	glucose	67,74	insulin	19,26	glucose	insulin	MESH:D005947	3630	Chemical	Gene	homeostasis|compound|START_ENTITY implications|nmod|homeostasis secretion|dep|implications secretion|compound|END_ENTITY	Modeling beta-cell insulin secretion -- implications for closed-loop glucose homeostasis .
14737746	0	glucose	33,40	insulin	66,73	glucose	insulin	MESH:D005947	3630	Chemical	Gene	excursions|compound|START_ENTITY reduces|dobj|excursions reduces|advcl|added added|nmod|lispro lispro|compound|END_ENTITY	Pramlintide reduces postprandial glucose excursions when added to insulin lispro in subjects with type 2 diabetes : a dose-timing study .
14741112	0	glucose	55,62	insulin	12,19	glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY delivery-the|nmod|control delivery-the|nsubj|END_ENTITY	Closed-loop insulin delivery-the path to physiological glucose control .
14747233	0	glucose	116,123	insulin	46,53	glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY endothelial_dysfunction|nmod|control ameliorates|dobj|endothelial_dysfunction ameliorates|nsubj|therapy therapy|nmod|resistance resistance|compound|END_ENTITY	In type 2 diabetes , rosiglitazone therapy for insulin resistance ameliorates endothelial_dysfunction independent of glucose control .
14754788	0	glucose	37,44	insulin	92,99	glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY impairment|nmod|control study|nmod|impairment caused|nsubj|study caused|nmod|changes changes|nmod|resistance resistance|compound|END_ENTITY	A prospective study of impairment in glucose control caused by clozapine without changes in insulin resistance .
14764798	0	glucose	175,182	insulin	97,104	glucose	insulin	MESH:D005947	3630	Chemical	Gene	cultured|nmod|START_ENTITY islets|acl|cultured preserves|nmod|islets preserves|dobj|stores stores|compound|END_ENTITY	Induction of beta-cell rest by a Kir6 .2 / SUR1-selective K -LRB- ATP -RRB- - channel opener preserves beta-cell insulin stores and insulin secretion in human islets cultured at high -LRB- 11 mM -RRB- glucose .
15001651	0	glucose	205,212	insulin	124,131	glucose	insulin	MESH:D005947	3630	Chemical	Gene	range|nmod|START_ENTITY patients|nmod|range resistance|nmod|patients resistance|compound|END_ENTITY	Quantitative_insulin_sensitivity check index and the reciprocal index of homeostasis model assessment are useful indexes of insulin resistance in type 2 diabetic patients with wide range of fasting plasma glucose .
15015278	2	glucose	495,502	insulin	439,446	glucose	insulin	MESH:D005947	3630	Chemical	Gene	absorption|nmod|START_ENTITY inhibit|dobj|absorption cause|advcl|inhibit cause|dobj|increase increase|nmod|output output|compound|END_ENTITY	Investigators attributed the hypoglycemic effect of these products to their ability to restore the functions of pancreatic tissues and cause an increase in insulin output , to inhibit the intestinal absorption of glucose , or to the facilitation of metabolites in insulin-dependent processes .
1511565	0	glucose	11,18	insulin	78,85	glucose	insulin	MESH:D005947	3630	Chemical	Gene	uptake|compound|START_ENTITY uptake|dep|effect effect|nmod|fatty_acids fatty_acids|compound|END_ENTITY	Peripheral glucose uptake and skeletal muscle GLUT4 content in man : effect of insulin and free fatty_acids .
15127193	0	glucose	91,98	insulin	31,38	glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY efficiency|nmod|control improves|dobj|efficiency improves|nsubj|Standardization Standardization|nmod|therapy therapy|compound|END_ENTITY	Standardization of intravenous insulin therapy improves the efficiency and safety of blood glucose control in critically ill adults .
15181067	0	glucose	119,126	insulin	29,36	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY impact|nmod|tolerance treatment|dep|impact treatment|nmod|resistance resistance|compound|END_ENTITY	Pharmacological treatment of insulin resistance at two different stages in the evolution of type 2 diabetes : impact on glucose tolerance and beta-cell function .
15198401	0	glucose	139,146	insulin	98,105	glucose	insulin	MESH:D005947	3630	Chemical	Gene	mean|dobj|START_ENTITY mean|nsubj|complications complications|dep|association association|nmod|amount amount|nmod|requirement requirement|compound|END_ENTITY	Foetomaternal complications in pregnancies with diabetes_mellitus : association with the amount of insulin requirement , mean terminal blood glucose and HbA1C levels .
1523247	0	glucose	83,90	insulin	39,46	glucose	insulin	MESH:D005947	3630	Chemical	Gene	injection|nmod|START_ENTITY alter|nmod|injection alter|dobj|response response|compound|END_ENTITY	Hepatic vagotomy does not alter plasma insulin response to a low dose injection of glucose .
15251512	0	glucose	14,21	insulin	47,54	glucose	insulin	MESH:D005947	3630	Chemical	Gene	levels|compound|START_ENTITY levels|nmod|therapy therapy|compound|END_ENTITY	Fasting blood glucose levels and initiation of insulin therapy in gestational_diabetes .
15260080	0	glucose	45,52	insulin	11,18	glucose	insulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY using|dobj|test Indexes|acl|using Indexes|nmod|resistance resistance|compound|END_ENTITY	Indexes of insulin resistance using the oral glucose tolerance test -LRB- O-GTT -RRB- in Japanese children and adolescents .
15271748	0	glucose	57,64	insulin	17,24	glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY regimen|nmod|control regimen|compound|END_ENTITY	A simple glucose insulin regimen for perioperative blood glucose control : the Vellore regimen .
15271748	0	glucose	9,16	insulin	17,24	glucose	insulin	MESH:D005947	3630	Chemical	Gene	regimen|compound|START_ENTITY regimen|compound|END_ENTITY	A simple glucose insulin regimen for perioperative blood glucose control : the Vellore regimen .
15312220	0	glucose	24,31	insulin	13,20	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY Influence|nmod|metabolism Influence|nmod|END_ENTITY	Influence of insulin on glucose metabolism and energy expenditure in septic patients .
15331546	0	glucose	151,158	insulin	105,112	glucose	insulin	MESH:D005947	3630	Chemical	Gene	relatives|compound|START_ENTITY secretion|nmod|relatives secretion|compound|END_ENTITY	Reduced hepatic insulin extraction in response to gastric inhibitory polypeptide compensates for reduced insulin secretion in normal-weight and normal glucose tolerant first-degree relatives of type 2 diabetic patients .
15331546	0	glucose	151,158	insulin	16,23	glucose	insulin	MESH:D005947	3630	Chemical	Gene	relatives|compound|START_ENTITY secretion|nmod|relatives compensates|nmod|secretion compensates|nsubj|extraction extraction|compound|END_ENTITY	Reduced hepatic insulin extraction in response to gastric inhibitory polypeptide compensates for reduced insulin secretion in normal-weight and normal glucose tolerant first-degree relatives of type 2 diabetic patients .
15334366	0	glucose	68,75	insulin	109,116	glucose	insulin	MESH:D005947	3630	Chemical	Gene	plasma|dobj|START_ENTITY plasma|nmod|release release|compound|END_ENTITY	Effects of weight_loss in obese subjects with normal fasting plasma glucose or impaired_glucose_tolerance on insulin release and insulin resistance according to a minimal model analysis .
15334385	0	glucose	67,74	insulin	119,126	glucose	insulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY fatty_acids|nmod|test profile|nmod|fatty_acids unresponsive|nsubj|profile unresponsive|nmod|END_ENTITY	The multiphasic profile of free fatty_acids during the intravenous glucose tolerance test is unresponsive to exogenous insulin .
1542855	0	glucose	18,25	insulin	111,118	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY action|nmod|metabolism action|dep|effects effects|nmod|END_ENTITY	Insulin action on glucose and branched-chain amino_acid metabolism in cancer_cachexia : differential effects of insulin .
15453119	0	glucose	51,58	insulin	13,20	glucose	insulin	MESH:D005947	3630	Chemical	Gene	Long|dep|START_ENTITY Long|acl|acting acting|dobj|analogs analogs|compound|END_ENTITY	-LSB- Long acting insulin analogs : possibly more stable glucose regulation -RSB- .
15481723	0	glucose	14,21	insulin	41,48	glucose	insulin	MESH:D005947	3630	Chemical	Gene	levels|compound|START_ENTITY Optimal|dobj|levels Optimal|advcl|using using|dobj|END_ENTITY	Optimal blood glucose levels while using insulin to minimize the size of infarction in focal cerebral_ischemia .
15505016	0	glucose	63,70	insulin	44,51	glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY mixing|nmod|control mixing|dobj|analogs analogs|compound|END_ENTITY	Effects of mixing glargine and short-acting insulin analogs on glucose control .
15520847	0	glucose	15,22	insulin	36,43	glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY control|nmod|END_ENTITY	How does blood glucose control with insulin save lives in intensive care ?
15522932	0	glucose	11,18	insulin	116,123	glucose	insulin	MESH:D005947	3630	Chemical	Gene	continuum|compound|START_ENTITY continuum|dep|evidence evidence|nmod|impairment impairment|nmod|independent independent|nmod|resistance resistance|compound|END_ENTITY	The normal glucose tolerance continuum in obese youth : evidence for impairment in beta-cell function independent of insulin resistance .
15536600	0	glucose	72,79	insulin	36,43	glucose	insulin	MESH:D005947	3630	Chemical	Gene	START_ENTITY|nsubj|rhythm rhythm|nmod|concentration concentration|compound|END_ENTITY	Preserved circadian rhythm of serum insulin concentration at low plasma glucose during fasting in lean and overweight humans .
15561932	0	glucose	87,94	insulin	28,35	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	uptake|compound|START_ENTITY required|nmod|uptake required|nsubjpass|changes changes|nmod|END_ENTITY	Exercise-induced changes in insulin and glucagon are not required for enhanced hepatic glucose uptake after exercise but influence the fate of glucose_within_the_liver .
15565374	0	glucose	172,179	insulin	37,44	glucose	insulin	MESH:D005947	3630	Chemical	Gene	minipig|nmod|START_ENTITY ttingen|acl|minipig population|nmod|ttingen compensation|nmod|population compensation|compound|END_ENTITY	Reduction of beta cell mass : partial insulin secretory compensation from the residual beta cell population in the nicotinamide-streptozotocin_G ttingen minipig after oral glucose in vivo and in the perfused pancreas .
1557335	0	glucose	78,85	insulin	87,94	glucose	insulin	MESH:D005947	3630	Chemical	Gene	C-peptide|compound|START_ENTITY C-peptide|dep|END_ENTITY	Effects of cholecystokinin receptor blockade on circulating concentrations of glucose , insulin , C-peptide , and pancreatic polypeptide after various meals in healthy human volunteers .
1559464	0	glucose	105,112	insulin	15,22	glucose	insulin	MESH:D005947	280829(Tax:9913)	Chemical	Gene	-RSB-|compound|START_ENTITY regulation|dobj|-RSB- regulation|nsubj|Estimation Estimation|nmod|END_ENTITY	-LSB- Estimation of insulin and glucose regulation in the dairy cow using daily profiles , simple and modified glucose tolerance test -RSB- .
15616023	0	glucose	83,90	insulin	35,42	glucose	insulin	MESH:D005947	3630	Chemical	Gene	load|compound|START_ENTITY interstitial|nmod|load interstitial|nsubj|delivery delivery|nmod|END_ENTITY	Delayed transcapillary delivery of insulin to muscle interstitial fluid after oral glucose load in obese subjects .
15639679	0	glucose	83,90	insulin	104,111	glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY control|nmod|END_ENTITY	Protection of hepatocyte mitochondrial ultrastructure and function by strict blood glucose control with insulin in critically_ill patients .
15642076	0	glucose	50,57	insulin	119,126	glucose	insulin	MESH:D005947	3630	Chemical	Gene	variability|nmod|START_ENTITY variability|acl|END_ENTITY	Lower within-subject variability of fasting blood glucose and reduced weight_gain with insulin detemir compared to NPH insulin in patients with type 2 diabetes .
15642076	0	glucose	50,57	insulin	87,94	glucose	insulin	MESH:D005947	3630	Chemical	Gene	variability|nmod|START_ENTITY variability|nmod|detemir detemir|compound|END_ENTITY	Lower within-subject variability of fasting blood glucose and reduced weight_gain with insulin detemir compared to NPH insulin in patients with type 2 diabetes .
15646368	0	glucose	6,13	insulin	59,66	glucose	insulin	MESH:D005947	3630	Chemical	Gene	profiles|compound|START_ENTITY profiles|acl|using using|dobj|preparations preparations|compound|END_ENTITY	Blood glucose profiles in diabetic rodents using different insulin preparations .
15650027	0	glucose	9,16	insulin	34,41	glucose	insulin	MESH:D005947	3630	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|activity activity|compound|END_ENTITY	Elevated glucose attenuates human insulin gene promoter activity in INS-1 pancreatic beta-cells via reduced nuclear factor binding to the A5/core and Z element .
156932	0	glucose	136,143	insulin	7,14	glucose	insulin	MESH:D005947	3630	Chemical	Gene	loading|nmod|START_ENTITY mothers|acl|loading infants|nmod|mothers changes|nmod|infants END_ENTITY|appos|changes	Plasma insulin , carbohydrate , and free fatty_acid changes in newly born infants of diabetic and non-diabetic mothers after loading with glucose , _ fructose , _ and_galactose .
15729576	0	glucose	29,36	insulin	81,88	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY effects|nmod|metabolism Comparison|nmod|effects Comparison|nmod|detemir detemir|compound|END_ENTITY	Comparison of the effects on glucose and lipid metabolism of equipotent doses of insulin detemir and NPH insulin with a 16-h euglycaemic clamp .
1574008	5	glucose	1001,1008	insulin	1048,1055	glucose	insulin	MESH:D005947	3630	Chemical	Gene	homeostasis|compound|START_ENTITY decompensate|nsubj|homeostasis decompensate|advcl|begins begins|nsubj|response response|compound|END_ENTITY	As a corollary , glucose homeostasis will decompensate when the insulin secretory response begins to decrease , and the greater the decline in insulin secretion , the larger the increase in plasma glucose concentration .
1574008	5	glucose	1179,1186	insulin	1048,1055	glucose	insulin	MESH:D005947	3630	Chemical	Gene	concentration|compound|START_ENTITY increase|nmod|concentration decrease|dep|increase begins|nmod|decrease begins|nsubj|response response|compound|END_ENTITY	As a corollary , glucose homeostasis will decompensate when the insulin secretory response begins to decrease , and the greater the decline in insulin secretion , the larger the increase in plasma glucose concentration .
15755768	0	glucose	67,74	insulin	35,42	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	delivery|nmod|START_ENTITY delivery|compound|END_ENTITY	Impact of continuous and pulsatile insulin delivery on net hepatic glucose uptake .
15793257	0	glucose	90,97	insulin	14,21	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	disposal|nmod|START_ENTITY associated|nmod|disposal associated|nsubjpass|Inhalation Inhalation|nmod|END_ENTITY	Inhalation of insulin -LRB- Exubera -RRB- is associated with augmented disposal of portally infused glucose in dogs .
15793257	1	glucose	276,283	insulin	198,205	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	load|compound|START_ENTITY provides|nmod|load provides|nsubj|END_ENTITY	The results of the present study , using the conscious beagle_dog , demonstrate that inhaled insulin -LRB- INH ; Exubera -RRB- provides better glycemic control during an intraportal glucose load than identical insulin levels induced by insulin -LRB- Humulin -RRB- infusion into the inferior vena cava -LRB- IVC -RRB- .
15828597	0	glucose	45,52	insulin	4,11	glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY Improves|dobj|control Improves|nsubj|protocol protocol|compound|END_ENTITY	New insulin infusion protocol Improves blood glucose control in hospitalized patients without increasing hypoglycemia .
15862282	0	glucose	90,97	insulin	199,206	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY polycystic_ovary_syndrome|nmod|tolerance test|amod|polycystic_ovary_syndrome women|nmod|test levels|nmod|women levels|dep|correlation correlation|nmod|independent independent|nmod|indices indices|compound|END_ENTITY	Adiponectin and resistin serum levels in women with polycystic_ovary_syndrome during oral glucose tolerance test : a significant reciprocal correlation between adiponectin and resistin independent of insulin resistance indices .
15863957	0	glucose	157,164	insulin	70,77	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY subjects|nmod|tolerance obese|appos|subjects resistance|nmod|obese resistance|compound|END_ENTITY	Quantitative_insulin_sensitivity check index is a useful indicator of insulin resistance in Japanese metabolically obese , normal-weight subjects with normal glucose tolerance .
15886226	0	glucose	38,45	insulin	72,79	glucose	insulin	MESH:D005947	3630	Chemical	Gene	delivery|compound|START_ENTITY increases|nsubj|delivery increases|dobj|END_ENTITY	Initially more rapid small intestinal glucose delivery increases plasma insulin , GIP , and GLP-1 but does not improve overall glycemia in healthy subjects .
15940468	0	glucose	62,69	insulin	167,174	glucose	insulin	MESH:D005947	3630	Chemical	Gene	Impaired|nmod|START_ENTITY Impaired|nsubj|postpartum postpartum|dep|role role|nmod|secretion secretion|compound|END_ENTITY	Impaired non-esterified fatty_acid suppression to intravenous glucose during late pregnancy persists postpartum in gestational diabetes : a dominant role for decreased insulin secretion rather than insulin resistance .
15940468	0	glucose	62,69	insulin	197,204	glucose	insulin	MESH:D005947	3630	Chemical	Gene	Impaired|nmod|START_ENTITY Impaired|nsubj|postpartum postpartum|dep|role role|nmod|secretion secretion|nmod|resistance resistance|compound|END_ENTITY	Impaired non-esterified fatty_acid suppression to intravenous glucose during late pregnancy persists postpartum in gestational diabetes : a dominant role for decreased insulin secretion rather than insulin resistance .
15949705	0	glucose	104,111	insulin	20,27	glucose	insulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY variants|nmod|test variants|nsubj|Interaction Interaction|nmod|END_ENTITY	Interaction between insulin -LRB- VNTR -RRB- and hepatic_lipase -LRB- LIPC-514C > T -RRB- variants on the response to an oral glucose tolerance test in the EARSII group of young healthy men .
15963037	0	glucose	24,31	insulin	102,109	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY Progression|nmod|tolerance Progression|dep|changes changes|nmod|sensitivity sensitivity|compound|END_ENTITY	Progression from normal glucose tolerance to type 2 diabetes in a young girl : longitudinal changes in insulin sensitivity and secretion assessed by the clamp technique and surrogate estimates .
15972269	0	glucose	46,53	insulin	35,42	glucose	insulin	MESH:D005947	3630	Chemical	Gene	disposal|compound|START_ENTITY Measurement|nmod|disposal Measurement|nmod|effect effect|nmod|END_ENTITY	Measurement of selective effect of insulin on glucose disposal from labeled glucose oral test minimal model .
15972269	0	glucose	76,83	insulin	35,42	glucose	insulin	MESH:D005947	3630	Chemical	Gene	model|compound|START_ENTITY Measurement|nmod|model Measurement|nmod|effect effect|nmod|END_ENTITY	Measurement of selective effect of insulin on glucose disposal from labeled glucose oral test minimal model .
15974246	0	glucose	18,25	insulin	80,87	glucose	insulin	MESH:D005947	3630	Chemical	Gene	uptake|compound|START_ENTITY reduce|dobj|uptake reduce|nmod|therapy therapy|compound|END_ENTITY	Host cells reduce glucose uptake and glycogen deposition in response to hepatic insulin gene therapy .
16014355	0	glucose	41,48	insulin	64,71	glucose	insulin	MESH:D005947	3630	Chemical	Gene	concentration|compound|START_ENTITY Maintenance|nmod|concentration Maintenance|dep|END_ENTITY	Maintenance of the postabsorptive plasma glucose concentration : insulin or insulin plus glucagon ?
16031860	0	glucose	23,30	insulin	12,19	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	ratio|compound|START_ENTITY END_ENTITY|nmod|ratio	The amended insulin to glucose ratio and diagnosis of insulinoma in dogs .
16050945	0	glucose	52,59	insulin	98,105	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY test|nsubj|tolerance test|parataxis|determine determine|dobj|resistance resistance|compound|END_ENTITY	Subcutaneous microdialysis before and after an oral glucose tolerance test : a method to determine insulin resistance in the subcutaneous adipose tissue in diabetes_mellitus .
16086844	0	glucose	32,39	insulin	71,78	glucose	insulin	MESH:D005947	3630	Chemical	Gene	injury|nmod|START_ENTITY prevented|nsubjpass|injury prevented|nmod|END_ENTITY	Endothelial cell injury by high glucose and heparanase is prevented by insulin , heparin and basic_fibroblast_growth_factor .
16120030	0	glucose	112,119	insulin	24,31	glucose	insulin	MESH:D005947	3630	Chemical	Gene	excursions|compound|START_ENTITY patterns|nmod|excursions display|dobj|patterns display|nsubj|infusion infusion|compound|END_ENTITY	Continuous subcutaneous insulin infusion and multiple dose of insulin regimen display similar patterns of blood glucose excursions in pediatric type 1 diabetes .
16120030	0	glucose	112,119	insulin	62,69	glucose	insulin	MESH:D005947	3630	Chemical	Gene	excursions|compound|START_ENTITY patterns|nmod|excursions display|dobj|patterns display|nsubj|infusion infusion|nmod|regimen regimen|compound|END_ENTITY	Continuous subcutaneous insulin infusion and multiple dose of insulin regimen display similar patterns of blood glucose excursions in pediatric type 1 diabetes .
16138265	0	glucose	161,168	insulin	117,124	glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY independent|nmod|control independent|compound|END_ENTITY	Pioneer study : PPARgamma activation results in overall improvement of clinical and metabolic markers associated with insulin resistance independent of long-term glucose control .
16160865	0	glucose	77,84	insulin	16,23	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY predicted|dobj|tolerance predicted|nsubj|secretion secretion|compound|END_ENTITY	K-value and low insulin secretion in a non-obese white population : predicted glucose tolerance after 25 years .
16168194	0	glucose	4,11	insulin	153,160	glucose	insulin	MESH:D005947	3630	Chemical	Gene	response|compound|START_ENTITY response|dep|indication indication|nmod|resistance resistance|compound|END_ENTITY	The glucose response to an oral fat tolerance test in young men with a paternal history of premature myocardial_infarction : possible early indication of insulin resistance .
16186268	0	glucose	113,120	insulin	68,75	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY individuals|nmod|tolerance secretion|nmod|individuals secretion|compound|END_ENTITY	Differences in cardiovascular risk factors , insulin resistance , and insulin secretion in individuals with normal glucose tolerance and in subjects with impaired_glucose_regulation : the Telde Study .
1618926	0	glucose	15,22	insulin	87,94	glucose	insulin	MESH:D005947	3630	Chemical	Gene	expression|compound|START_ENTITY Alterations|nmod|expression Alterations|dep|mechanisms mechanisms|nmod|resistance resistance|compound|END_ENTITY	Alterations in glucose transporter expression and function in diabetes : mechanisms for insulin resistance .
16207627	0	glucose	13,20	insulin	48,55	glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY Influence|nmod|control Influence|nmod|resistance resistance|compound|END_ENTITY	Influence of glucose control and improvement of insulin resistance on microvascular blood flow and endothelial function in patients with diabetes_mellitus_type_2 .
16239201	0	glucose	194,201	insulin	106,113	glucose	insulin	MESH:D005947	3630	Chemical	Gene	system|compound|START_ENTITY using|dobj|system study|acl|using infusion|dep|study infusion|compound|END_ENTITY	Switch to multiple_daily_injections with insulin glargine and insulin lispro from continuous subcutaneous insulin infusion with insulin lispro : a randomized , open-label study using a continuous glucose monitoring system .
16239201	0	glucose	194,201	insulin	128,135	glucose	insulin	MESH:D005947	3630	Chemical	Gene	system|compound|START_ENTITY using|dobj|system study|acl|using infusion|dep|study infusion|nmod|lispro lispro|compound|END_ENTITY	Switch to multiple_daily_injections with insulin glargine and insulin lispro from continuous subcutaneous insulin infusion with insulin lispro : a randomized , open-label study using a continuous glucose monitoring system .
16239201	0	glucose	194,201	insulin	41,48	glucose	insulin	MESH:D005947	3630	Chemical	Gene	system|compound|START_ENTITY using|dobj|system study|acl|using infusion|dep|study infusion|amod|Switch Switch|nmod|multiple_daily_injections multiple_daily_injections|nmod|glargine glargine|compound|END_ENTITY	Switch to multiple_daily_injections with insulin glargine and insulin lispro from continuous subcutaneous insulin infusion with insulin lispro : a randomized , open-label study using a continuous glucose monitoring system .
16260353	0	glucose	117,124	insulin	64,71	glucose	insulin	MESH:D005947	3630	Chemical	Gene	concentrations|nmod|START_ENTITY secretion|nmod|concentrations secretion|nsubj|Effect Effect|nmod|administration administration|nmod|dose dose|nmod|nateglinide nateglinide|nmod|END_ENTITY	Effect of the administration of a single dose of nateglinide on insulin secretion at two different concentrations of glucose in healthy individuals .
16278244	0	glucose	114,121	insulin	36,43	glucose	insulin	MESH:D005947	3630	Chemical	Gene	exposure|compound|START_ENTITY entrained|nmod|exposure entrained|nsubjpass|mass mass|nmod|bursts bursts|compound|END_ENTITY	The mass , but not the frequency , of insulin secretory bursts in isolated human islets is entrained by oscillatory glucose exposure .
16332653	0	glucose	138,145	insulin	118,125	glucose	insulin	MESH:D005947	3630	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Independent association of insulin resistance with larger amounts of intermuscular adipose_tissue and a greater acute insulin response to glucose in African American than in white nondiabetic women .
16353361	0	glucose	55,62	insulin	13,20	glucose	insulin	MESH:D005947	704534(Tax:9544)	Chemical	Gene	tolerance|compound|START_ENTITY monkeys|nmod|tolerance Diversity|nmod|monkeys Diversity|nmod|resistance resistance|compound|END_ENTITY	Diversity of insulin resistance in monkeys with normal glucose tolerance .
16353672	0	glucose	118,125	insulin	41,48	glucose	insulin	MESH:D005947	3630	Chemical	Gene	load|compound|START_ENTITY effect|nmod|load effect|nmod|supplement supplement|nmod|sensitivity sensitivity|compound|END_ENTITY	The effect of testosterone supplement on insulin sensitivity , glucose effectiveness , and acute insulin response after glucose load in male_type_2 diabetics .
16415763	7	glucose	1390,1397	insulin	1370,1377	glucose	insulin	MESH:D005947	3630	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	However , insulin secretion appears to decrease with age , with significantly diminished beta-cell sensitivity and acute insulin response to glucose , provided it is analyzed relative to concomitant decreased_insulin_sensitivity .
16447058	0	glucose	107,114	insulin	46,53	glucose	insulin	MESH:D005947	3630	Chemical	Gene	concentration|compound|START_ENTITY changes|nmod|concentration secretion|nmod|changes secretion|nsubj|END_ENTITY	Gamma-aminobutyric_acid up - and downregulates insulin secretion from beta cells in concert with changes in glucose concentration .
1644911	0	glucose	112,119	insulin	16,23	glucose	insulin	MESH:D005947	3630	Chemical	Gene	concentrations|compound|START_ENTITY secretion|nmod|concentrations secretion|nsubj|Preservation Preservation|nmod|levels levels|compound|END_ENTITY	Preservation of insulin mRNA levels and insulin secretion in HIT cells by avoidance of chronic exposure to high glucose concentrations .
16505665	0	glucose	48,55	insulin	10,17	glucose	insulin	MESH:D005947	3630	Chemical	Gene	values|compound|START_ENTITY reduces|dobj|values reduces|nsubj|therapy therapy|compound|END_ENTITY	Intensive insulin therapy reduces microdialysis glucose values without altering glucose utilization or improving the lactate/pyruvate ratio after traumatic_brain_injury .
16505665	0	glucose	80,87	insulin	10,17	glucose	insulin	MESH:D005947	3630	Chemical	Gene	utilization|compound|START_ENTITY altering|dobj|utilization reduces|advcl|altering reduces|nsubj|therapy therapy|compound|END_ENTITY	Intensive insulin therapy reduces microdialysis glucose values without altering glucose utilization or improving the lactate/pyruvate ratio after traumatic_brain_injury .
16531895	0	glucose	68,75	insulin	22,29	glucose	insulin	MESH:D005947	3630	Chemical	Gene	disposal|compound|START_ENTITY secretion|nmod|disposal secretion|compound|END_ENTITY	Effects of increasing insulin secretion on acute postexercise blood glucose disposal .
16538487	0	glucose	28,35	insulin	71,78	glucose	insulin	MESH:D005947	3630	Chemical	Gene	prevalence|nmod|START_ENTITY homeostasis|nsubj|prevalence homeostasis|xcomp|secondary secondary|nmod|secretion secretion|compound|END_ENTITY	High prevalence of abnormal glucose homeostasis secondary to decreased insulin secretion in individuals with hereditary_haemochromatosis .
16538487	9	glucose	1205,1212	insulin	1185,1192	glucose	insulin	MESH:D005947	3630	Chemical	Gene	had|nmod|START_ENTITY had|dobj|decrease decrease|nmod|response response|compound|END_ENTITY	However , patients with haemochromatosis and IGT had a 68 % decrease in acute insulin response to glucose -LRB- p < 0.02 -RRB- compared with those with NGT .
16549443	0	glucose	34,41	insulin	18,25	glucose	insulin	MESH:D005947	3630	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|gene gene|compound|END_ENTITY	Regulation of the insulin gene by glucose and fatty_acids .
16595595	0	glucose	92,99	insulin	55,62	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tests|compound|START_ENTITY estimating|nmod|tests estimating|dobj|sensitivity sensitivity|compound|END_ENTITY	The role of endocrine counterregulation for estimating insulin sensitivity from intravenous glucose tolerance tests .
16608860	0	glucose	13,20	insulin	34,41	glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|nsubj|START_ENTITY control|nmod|END_ENTITY	Strict blood glucose control with insulin during intensive care after cardiac surgery : impact on 4-years survival , dependency on medical care , and quality-of-life .
1666765	0	glucose	35,42	insulin	11,18	glucose	insulin	MESH:D005947	3630	Chemical	Gene	changes|compound|START_ENTITY mediated|dobj|changes mediated|nsubj|Effects Effects|nmod|END_ENTITY	Effects of insulin mediated plasma glucose changes on brain function .
16676512	0	glucose	53,60	insulin	9,16	glucose	insulin	MESH:D005947	3630	Chemical	Gene	-RSB-|compound|START_ENTITY optimisation|nmod|-RSB- route|nmod|optimisation END_ENTITY|dep|route	-LSB- Inhaled insulin : a new route in the optimisation of glucose regulation -RSB- .
16687234	9	glucose	1227,1234	insulin	1394,1401	glucose	insulin	MESH:D005947	493804(Tax:9685)	Chemical	Gene	rate|amod|START_ENTITY neutered|nsubj|rate neutered|ccomp|suggests suggests|ccomp|able able|xcomp|replete replete|nmod|END_ENTITY	The higher glucose oxidation rate in obese neutered male cats suggests that they are able to replete their glycogen and lipid stores at a faster rate than females in response to insulin and it implies that they gain weight more rapidly .
16749339	9	glucose	1374,1381	insulin	1399,1406	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	reduced|nsubjpass|START_ENTITY reduced|nmod|END_ENTITY	From the results , it was concluded that the small intestine increased its glucose uptake in response to the hyperglycemia in alloxan-induced diabetes and when the blood glucose was reduced with insulin the intestine also reduced its glucose uptake accordingly .
16749339	9	glucose	1438,1445	insulin	1399,1406	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	uptake|compound|START_ENTITY reduced|dobj|uptake reduced|advcl|reduced reduced|nmod|END_ENTITY	From the results , it was concluded that the small intestine increased its glucose uptake in response to the hyperglycemia in alloxan-induced diabetes and when the blood glucose was reduced with insulin the intestine also reduced its glucose uptake accordingly .
16771083	0	glucose	23,30	insulin	12,19	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY Effects|nmod|metabolism Effects|nmod|END_ENTITY	-LSB- Effects of insulin on glucose metabolism in sepsis -RSB- .
16772658	0	glucose	76,83	insulin	12,19	glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY optimizing|dep|control replacement|dep|optimizing replacement|compound|END_ENTITY	Physiologic insulin replacement in type 2 diabetes : optimizing postprandial glucose control .
1679440	0	glucose	28,35	insulin	12,19	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	permits|dobj|START_ENTITY permits|nsubj|END_ENTITY	Intra-islet insulin permits glucose to directly suppress pancreatic A cell function .
1680214	0	glucose	30,37	insulin	69,76	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	uptake|compound|START_ENTITY enhances|dobj|uptake enhances|nmod|presence presence|nmod|END_ENTITY	Adenosine enhances myocardial glucose uptake only in the presence of insulin .
16842476	0	glucose	85,92	insulin	118,125	glucose	insulin	MESH:D005947	3630	Chemical	Gene	levels|compound|START_ENTITY lowers|dobj|levels lowers|advcl|END_ENTITY	Insulin detemir lowers the risk of hypoglycaemia and provides more consistent plasma glucose levels compared with NPH insulin in Type 1 diabetes .
16874843	0	glucose	18,25	insulin	103,110	glucose	insulin	MESH:D005947	3630	Chemical	Gene	Achieving|dobj|START_ENTITY control|csubj|Achieving control|dobj|protocol protocol|compound|END_ENTITY	Achieving durable glucose control in the intensive care unit without hypoglycaemia : a new practical IV insulin protocol .
16941278	0	glucose	61,68	insulin	72,79	glucose	insulin	MESH:D005947	3630	Chemical	Gene	administered|nmod|START_ENTITY administered|nmod|concentrations concentrations|compound|END_ENTITY	Effect of orally administered phenylalanine with and without glucose on insulin , glucagon and glucose concentrations .
16979255	0	glucose	93,100	insulin	33,40	glucose	insulin	MESH:D005947	3630	Chemical	Gene	system|compound|START_ENTITY glargine|nmod|system glargine|nsubj|Evaluation Evaluation|nmod|superiority superiority|nmod|END_ENTITY	Evaluation of the superiority of insulin glargine as basal insulin replacement by continuous glucose monitoring system .
16979255	0	glucose	93,100	insulin	59,66	glucose	insulin	MESH:D005947	3630	Chemical	Gene	system|compound|START_ENTITY glargine|nmod|system glargine|nmod|replacement replacement|compound|END_ENTITY	Evaluation of the superiority of insulin glargine as basal insulin replacement by continuous glucose monitoring system .
17003270	0	glucose	50,57	insulin	31,38	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	Direct and indirect effects of insulin on hepatic glucose production in diabetic depancreatized dogs during euglycemia .
17003358	0	glucose	133,140	insulin	113,120	glucose	insulin	MESH:D005947	3630	Chemical	Gene	reduce|nmod|START_ENTITY reduce|dobj|response response|compound|END_ENTITY	Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals .
17069922	0	glucose	54,61	insulin	105,112	glucose	insulin	MESH:D005947	3630	Chemical	Gene	level|compound|START_ENTITY fasting|dobj|level fasting|nmod|dosing dosing|nmod|analog analog|compound|END_ENTITY	Factors associated with improvement of fasting plasma glucose level by mealtime dosing of a rapid-acting insulin analog in type 2 diabetes .
17084385	2	glucose	259,266	insulin	312,319	glucose	insulin	MESH:D005947	3630	Chemical	Gene	caused|nmod|START_ENTITY caused|nmod|secretion secretion|compound|END_ENTITY	In 5 mM glucose , pioglitazone caused a transient increase in insulin secretion in non-diabetic , but not diabetic , islets .
171158	0	glucose	28,35	insulin	17,24	glucose	insulin	MESH:D005947	3630	Chemical	Gene	permeability|compound|START_ENTITY influence|nmod|permeability influence|nmod|END_ENTITY	The influence of insulin on glucose permeability and metabolism of human granulocytes .
17130510	0	glucose	72,79	insulin	20,27	glucose	insulin	MESH:D005947	3630	Chemical	Gene	uptake|compound|START_ENTITY efficiency|nmod|uptake augments|dobj|efficiency augments|nsubj|Inhalation Inhalation|nmod|END_ENTITY	Inhalation of human insulin -LRB- exubera -RRB- augments the efficiency of muscle glucose uptake in vivo .
17215967	0	glucose	51,58	insulin	11,18	glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY improves|dobj|control improves|nsubj|infusion infusion|compound|END_ENTITY	Continuous insulin infusion improves postoperative glucose control in patients with diabetes_mellitus undergoing coronary artery bypass surgery .
17224874	0	glucose	69,76	insulin	29,36	glucose	insulin	MESH:D005947	3630	Chemical	Gene	effects|nmod|START_ENTITY effects|compound|END_ENTITY	Anti-inflammatory effects of insulin and pro-inflammatory effects of glucose : relevance to the management of acute myocardial_infarction and other acute_coronary_syndromes .
17239301	0	glucose	48,55	insulin	107,114	glucose	insulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY Glucose|nmod|test Glucose|dep|application application|nmod|index index|compound|END_ENTITY	-LSB- Glucose and insulin concentrations during oral glucose tolerance test in healthy children -- application of insulin resistance index according to Belfiore in the developmental age -RSB- .
17286248	0	glucose	58,65	insulin	95,102	glucose	insulin	MESH:D005947	3630	Chemical	Gene	production|compound|START_ENTITY dynamics|nmod|production model|nmod|dynamics model|nmod|level level|compound|END_ENTITY	A statistical model for inter-temporal causal dynamics of glucose production and disposal with insulin level in diabetic patients .
17307055	0	glucose	27,34	insulin	67,74	glucose	insulin	MESH:D005947	3630	Chemical	Gene	effect|compound|START_ENTITY effect|nmod|END_ENTITY	Proinflammatory effects of glucose and anti-inflammatory effect of insulin : relevance to cardiovascular_disease .
17322583	0	glucose	89,96	insulin	30,37	glucose	insulin	MESH:D005947	3630	Chemical	Gene	concentrations|compound|START_ENTITY cells|nmod|concentrations augments|nmod|cells augments|dobj|secretion secretion|compound|END_ENTITY	Globular adiponectin augments insulin secretion from pancreatic islet beta cells at high glucose concentrations .
17327442	1	glucose	241,248	insulin	264,271	glucose	insulin	MESH:D005947	3630	Chemical	Gene	fatty_acids|nmod|START_ENTITY oxidation|nmod|fatty_acids switching|nmod|oxidation switching|nmod|END_ENTITY	Insulin resistance is associated with metabolic_inflexibility , impaired switching of substrate oxidation from fatty_acids to glucose in response to insulin .
17341552	0	glucose	134,141	insulin	64,71	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tests|compound|START_ENTITY Assessment|nmod|tests Assessment|nmod|sensitivity sensitivity|compound|END_ENTITY	Assessment of beta-cell function in humans , simultaneously with insulin sensitivity and hepatic extraction , from intravenous and oral glucose tests .
17385686	0	glucose	91,98	insulin	65,72	glucose	insulin	MESH:D005947	3630	Chemical	Gene	status|compound|START_ENTITY resistance|nmod|status resistance|compound|END_ENTITY	Insulin and C-peptide levels , pancreatic beta cell function , and insulin resistance across glucose tolerance status in Thais .
17395025	0	glucose	73,80	insulin	29,36	glucose	insulin	MESH:D005947	3630	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Anti-inflammatory effects of insulin and the pro-inflammatory effects of glucose .
17408014	0	glucose	33,40	insulin	77,84	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY evaluation|nmod|tolerance test|nsubj|evaluation test|nmod|diagnosis diagnosis|nmod|resistance resistance|compound|END_ENTITY	-LSB- Critical evaluation of the oral glucose tolerance test for the diagnosis of insulin resistance in patients with polycystic_ovary_syndrome -RSB- .
1743436	0	glucose	93,100	insulin	46,53	glucose	insulin	MESH:D005947	3630	Chemical	Gene	role|nmod|START_ENTITY insights|dep|role insights|nmod|regulation regulation|nmod|action action|compound|END_ENTITY	New insights into the metabolic regulation of insulin action and insulin resistance : role of glucose and amino_acids .
17478001	0	glucose	20,27	insulin	63,70	glucose	insulin	MESH:D005947	3630	Chemical	Gene	homeostasis|compound|START_ENTITY role|nmod|homeostasis role|nmod|resistance resistance|compound|END_ENTITY	The role of GSK3 in glucose homeostasis and the development of insulin resistance .
17515702	0	glucose	6,13	insulin	29,36	glucose	insulin	MESH:D005947	3630	Chemical	Gene	changes|nsubj|START_ENTITY changes|nmod|therapy therapy|compound|END_ENTITY	Serum glucose changes during insulin therapy in pediatric patients with diabetic_ketoacidosis .
175203	0	glucose	70,77	insulin	98,105	glucose	insulin	MESH:D005947	3630	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|release release|compound|END_ENTITY	Monolayer cell culture of human pancreatic_beta_cell_tumor : effect of glucose and somatostatin on insulin release .
17530249	0	glucose	96,103	insulin	30,37	glucose	insulin	MESH:D005947	3630	Chemical	Gene	transport|compound|START_ENTITY tracer|nmod|transport using|dobj|tracer probes|acl|using resistance|nmod|probes resistance|compound|END_ENTITY	In vivo assessment of cardiac insulin resistance by nuclear probes using an iodinated tracer of glucose transport .
17561482	0	glucose	64,71	insulin	23,30	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY correlation|nmod|metabolism Effect|nmod|correlation Effect|nmod|resistance resistance|compound|END_ENTITY	-LSB- Effect of progressive insulin resistance on the correlation of glucose metabolism and bone status -RSB- .
17570879	7	glucose	1249,1256	insulin	1290,1297	glucose	insulin	MESH:D005947	3630	Chemical	Gene	levels|compound|START_ENTITY levels|nmod|subjects subjects|acl:relcl|received received|iobj|> >|compound|END_ENTITY	There was a statistically significant difference -LRB- P = .033 -RRB- between mean prelunch glucose levels for subjects who received insulin > 45 minutes before breakfast and mean glucose levels for those who received insulin < 45 minutes before breakfast .
17570879	7	glucose	1335,1342	insulin	1290,1297	glucose	insulin	MESH:D005947	3630	Chemical	Gene	levels|compound|START_ENTITY received|nmod|levels received|iobj|> >|compound|END_ENTITY	There was a statistically significant difference -LRB- P = .033 -RRB- between mean prelunch glucose levels for subjects who received insulin > 45 minutes before breakfast and mean glucose levels for those who received insulin < 45 minutes before breakfast .
17606872	0	glucose	70,77	insulin	26,33	glucose	insulin	MESH:D005947	3630	Chemical	Gene	concentration|compound|START_ENTITY supports|dobj|concentration supports|nsubj|Glucagon Glucagon|nmod|concert concert|nmod|END_ENTITY	Glucagon , in concert with insulin , supports the postabsorptive plasma glucose concentration in humans .
1761067	0	glucose	24,31	insulin	58,65	glucose	insulin	MESH:D005947	3630	Chemical	Gene	potentiation|compound|START_ENTITY potentiation|nmod|response response|compound|END_ENTITY	Effect of nifedipine on glucose potentiation of the acute insulin response to arginine in non-insulin-dependent diabetics .
17625087	0	glucose	12,19	insulin	33,40	glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY control|nmod|END_ENTITY	Tight blood glucose control with insulin in the ICU : facts and controversies .
17661834	0	glucose	142,149	insulin	7,14	glucose	insulin	MESH:D005947	3630	Chemical	Gene	using|nmod|START_ENTITY removed|advcl|using removed|nsubjpass|END_ENTITY	Plasma insulin is removed by hemodialysis : evaluation of the relation between plasma insulin and glucose by using a dialysate with or without glucose .
17661834	0	glucose	142,149	insulin	85,92	glucose	insulin	MESH:D005947	3630	Chemical	Gene	using|nmod|START_ENTITY removed|advcl|using removed|nmod|hemodialysis hemodialysis|dep|evaluation evaluation|nmod|relation relation|nmod|END_ENTITY	Plasma insulin is removed by hemodialysis : evaluation of the relation between plasma insulin and glucose by using a dialysate with or without glucose .
17697856	0	glucose	137,144	insulin	10,17	glucose	insulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY derived|nmod|test comparison|acl|derived comparison|dep|Measuring Measuring|dobj|sensitivity sensitivity|compound|END_ENTITY	Measuring insulin sensitivity in postmenopausal women covering a range of glucose tolerance : comparison of indices derived from the oral glucose tolerance test with the euglycemic-hyperinsulinemic_clamp .
17697856	0	glucose	74,81	insulin	10,17	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY range|nmod|tolerance covering|dobj|range women|acl|covering Measuring|nmod|women Measuring|dobj|sensitivity sensitivity|compound|END_ENTITY	Measuring insulin sensitivity in postmenopausal women covering a range of glucose tolerance : comparison of indices derived from the oral glucose tolerance test with the euglycemic-hyperinsulinemic_clamp .
17702957	0	glucose	36,43	insulin	69,76	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY tolerance|nmod|sensitivity sensitivity|compound|END_ENTITY	Treadmill aerobic training improves glucose tolerance and indices of insulin sensitivity in disabled stroke survivors : a preliminary report .
17706318	0	glucose	124,131	insulin	26,33	glucose	insulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY disposal|nmod|test assessment|nmod|disposal assessment|nmod|sensitivity sensitivity|compound|END_ENTITY	Model-based assessment of insulin sensitivity of glucose disposal and endogenous glucose production from double-tracer oral glucose tolerance test .
17706318	0	glucose	49,56	insulin	26,33	glucose	insulin	MESH:D005947	3630	Chemical	Gene	disposal|compound|START_ENTITY assessment|nmod|disposal assessment|nmod|sensitivity sensitivity|compound|END_ENTITY	Model-based assessment of insulin sensitivity of glucose disposal and endogenous glucose production from double-tracer oral glucose tolerance test .
17709880	0	glucose	22,29	insulin	43,50	glucose	insulin	MESH:D005947	3630	Chemical	Gene	transport|compound|START_ENTITY transport|nmod|END_ENTITY	Insulin signaling and glucose transport in insulin resistant human skeletal muscle .
1777653	4	glucose	1261,1268	insulin	1167,1174	glucose	insulin	MESH:D005947	3630	Chemical	Gene	concentrations|compound|START_ENTITY relating|nmod|concentrations line|acl|relating slope|nmod|line changing|dobj|slope augmented|advcl|changing augmented|dobj|response response|compound|END_ENTITY	Glipizide augmented the first-phase insulin response without changing the slope of the regression line relating plasma insulin to glucose concentrations .
1787535	0	glucose	53,60	insulin	76,83	glucose	insulin	MESH:D005947	3630	Chemical	Gene	stimulation|compound|START_ENTITY stimulation|nmod|secretion secretion|compound|END_ENTITY	Role of voltage-dependent ionic currents in coupling glucose stimulation to insulin secretion in canine pancreatic islet B-cells .
17878636	0	glucose	111,118	insulin	30,37	glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY comparing|nmod|control Switching|parataxis|comparing Switching|nmod|END_ENTITY	Switching from premixed human insulin to premixed insulin lispro : a prospective study comparing the effects on glucose control and quality of life .
17878636	0	glucose	111,118	insulin	50,57	glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY comparing|nmod|control Switching|parataxis|comparing Switching|nmod|lispro lispro|compound|END_ENTITY	Switching from premixed human insulin to premixed insulin lispro : a prospective study comparing the effects on glucose control and quality of life .
17884459	0	glucose	140,147	insulin	45,52	glucose	insulin	MESH:D005947	3630	Chemical	Gene	resistance|nmod|START_ENTITY resistance|compound|END_ENTITY	Contribution of nonesterified fatty_acids to insulin resistance in the elderly with normal fasting but diabetic 2-hour postchallenge plasma glucose levels : the Baltimore Longitudinal Study of Aging .
17905511	0	glucose	67,74	insulin	35,42	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY subjects|nmod|tolerance END_ENTITY|nmod|subjects	First phase release coefficient of insulin in subjects with normal glucose tolerance on glucose infusion analyzed by computer simulation .
17905511	0	glucose	88,95	insulin	35,42	glucose	insulin	MESH:D005947	3630	Chemical	Gene	infusion|compound|START_ENTITY tolerance|nmod|infusion subjects|nmod|tolerance END_ENTITY|nmod|subjects	First phase release coefficient of insulin in subjects with normal glucose tolerance on glucose infusion analyzed by computer simulation .
17919763	0	glucose	66,73	insulin	12,19	glucose	insulin	MESH:D005947	3630	Chemical	Gene	glargine|nmod|START_ENTITY glargine|nsubj|Efficacy Efficacy|nmod|END_ENTITY	Efficacy of insulin glargine and glimepiride in controlling blood glucose of ethnic Japanese patients with type_2_diabetes_mellitus .
17931573	10	glucose	1405,1412	insulin	1327,1334	glucose	insulin	MESH:D005947	3630	Chemical	Gene	excursions|compound|START_ENTITY increases|nmod|excursions result|nmod|increases increased|nmod|result increased|nsubj|requirements requirements|compound|END_ENTITY	In patients whose insulin requirements have increased as a result of increases in post-prandial glucose excursions , prandial insulin should be added following a stepwise approach to therapy .
17947036	0	glucose	21,28	insulin	31,38	glucose	insulin	MESH:D005947	3630	Chemical	Gene	based|dobj|START_ENTITY network|acl|based network|dep|models models|compound|END_ENTITY	Neural network based glucose - insulin metabolism models for children with Type 1 diabetes .
18029467	0	glucose	100,107	insulin	8,15	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY studies|nmod|metabolism resistance|dep|studies resistance|compound|END_ENTITY	Hepatic insulin resistance in antipsychotic naive schizophrenic patients : stable isotope studies of glucose metabolism .
18049122	0	glucose	27,34	insulin	6,13	glucose	insulin	MESH:D005947	3630	Chemical	Gene	Acute|nmod|START_ENTITY Acute|dobj|responses responses|compound|END_ENTITY	Acute insulin responses to glucose and arginine as predictors of beta-cell secretory capacity in human islet transplantation .
18050666	0	glucose	98,105	insulin	23,30	glucose	insulin	MESH:D005947	3630	Chemical	Gene	-RSB-|compound|START_ENTITY subjects|nmod|-RSB- sensitivity|nmod|subjects sensitivity|compound|END_ENTITY	-LSB- The effects of age on insulin sensitivity and insulin secretion in Japanese subjects with normal glucose tolerance -RSB- .
18051927	0	glucose	33,40	insulin	91,98	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY levels|nmod|tolerance test|nsubj|levels test|nmod|resistance resistance|compound|END_ENTITY	Ghrelin serum levels during oral glucose tolerance test in prepubertal obese children with insulin resistance .
18076356	0	glucose	64,71	insulin	125,132	glucose	insulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY levels|nmod|test variability|nmod|levels variability|dep|influence influence|nmod|intervals intervals|nmod|END_ENTITY	Assay-dependent variability of serum insulin levels during oral glucose tolerance test : influence on reference intervals for insulin and on cut-off values for insulin sensitivity indices .
18076356	0	glucose	64,71	insulin	37,44	glucose	insulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY levels|nmod|test levels|compound|END_ENTITY	Assay-dependent variability of serum insulin levels during oral glucose tolerance test : influence on reference intervals for insulin and on cut-off values for insulin sensitivity indices .
18160753	0	glucose	29,36	insulin	59,66	glucose	insulin	MESH:D005947	3630	Chemical	Gene	vitamin_C|nmod|START_ENTITY Effect|nmod|vitamin_C lipids|nsubj|Effect lipids|dobj|END_ENTITY	Effect of vitamin_C on blood glucose , serum lipids _ serum insulin in type 2 diabetes patients .
18166815	0	glucose	103,110	insulin	40,47	glucose	insulin	MESH:D005947	3630	Chemical	Gene	Impact|nmod|START_ENTITY Impact|nmod|END_ENTITY	Impact of metformin versus the prandial insulin secretagogue , repaglinide , on fasting and postprandial glucose and lipid responses in non-obese patients with type 2 diabetes .
18223011	0	glucose	171,178	insulin	151,158	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	disposal|compound|START_ENTITY limits|nmod|disposal limits|dobj|course course|nmod|END_ENTITY	Direct administration of insulin into skeletal muscle reveals that the transport of insulin across the capillary endothelium limits the time course of insulin to activate glucose disposal .
18223011	0	glucose	171,178	insulin	25,32	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	disposal|compound|START_ENTITY limits|nmod|disposal reveals|ccomp|limits reveals|nsubj|administration administration|nmod|END_ENTITY	Direct administration of insulin into skeletal muscle reveals that the transport of insulin across the capillary endothelium limits the time course of insulin to activate glucose disposal .
18223011	0	glucose	171,178	insulin	84,91	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	disposal|compound|START_ENTITY limits|nmod|disposal limits|nsubj|transport transport|nmod|END_ENTITY	Direct administration of insulin into skeletal muscle reveals that the transport of insulin across the capillary endothelium limits the time course of insulin to activate glucose disposal .
18230695	0	glucose	8,15	insulin	46,53	glucose	insulin	MESH:D005947	3630	Chemical	Gene	levels|compound|START_ENTITY qualify|nsubj|levels qualify|dobj|potency potency|nmod|actions actions|compound|END_ENTITY	Ambient glucose levels qualify the potency of insulin myogenic actions by regulating SIRT1 and FoxO3a in C2C12 myocytes .
18293064	3	glucose	571,578	insulin	596,603	glucose	insulin	MESH:D005947	3630	Chemical	Gene	concentrations|nmod|START_ENTITY treating|nmod|concentrations treating|nmod|secretagogues secretagogues|compound|END_ENTITY	Glucose-responsive secretion of human insulin was determined by treating rAAV-transduced Huh7 human hepatoma cells with varying concentrations of glucose , with or without insulin secretagogues .
18328342	0	glucose	12,19	insulin	51,58	glucose	insulin	MESH:D005947	3630	Chemical	Gene	Use|nmod|START_ENTITY Use|dep|index index|nmod|sensitivity sensitivity|compound|END_ENTITY	Use of oral glucose minimal model-derived index of insulin sensitivity in subjects with early type_1_diabetes_mellitus .
1837510	0	glucose	44,51	insulin	74,81	glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY control|nmod|regimen regimen|compound|END_ENTITY	Does flexibility at mealtimes disturb blood glucose control on a multiple insulin injection regimen ?
18430770	0	glucose	137,144	insulin	46,53	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY related|nmod|tolerance related|nmod|resistance resistance|compound|END_ENTITY	Serum retinol binding protein 4 is related to insulin resistance and nonoxidative glucose metabolism in lean and obese women with normal glucose tolerance .
18430774	0	glucose	47,54	insulin	25,32	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY induces|nmod|metabolism induces|dobj|resistance resistance|compound|END_ENTITY	Hyperinsulinemia induces insulin resistance on glucose and lipid metabolism in a human adipocytic cell line : paracrine interaction with myocytes .
18442631	0	glucose	16,23	insulin	121,128	glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|nsubj|START_ENTITY control|parataxis|contributes contributes|advmod|more more|nmod|END_ENTITY	Intensive blood glucose control in acute and prolonged critical_illness : endogenous secretion contributes more to plasma insulin than exogenous insulin infusion .
18442631	0	glucose	16,23	insulin	144,151	glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|nsubj|START_ENTITY control|parataxis|contributes contributes|nmod|infusion infusion|compound|END_ENTITY	Intensive blood glucose control in acute and prolonged critical_illness : endogenous secretion contributes more to plasma insulin than exogenous insulin infusion .
18466639	0	glucose	67,74	insulin	29,36	glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY targeting|dobj|control targeting|nsubj|therapy therapy|compound|END_ENTITY	Pro/con debate : Is intensive insulin therapy targeting tight blood glucose control of benefit in critically ill patients ?
1846787	0	glucose	58,65	insulin	47,54	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY relationships|nmod|metabolism relationships|nmod|effects effects|nmod|END_ENTITY	Dose-response relationships for the effects of insulin on glucose and fat metabolism in injured patients and control subjects .
18471141	0	glucose	100,107	insulin	134,141	glucose	insulin	MESH:D005947	493804(Tax:9685)	Chemical	Gene	concentrations|compound|START_ENTITY duration|nmod|concentrations have|dobj|duration have|nmod|END_ENTITY	Glargine and protamine_zinc insulin have a longer duration of action and result in lower mean daily glucose concentrations than lente insulin in healthy cats .
18471141	0	glucose	100,107	insulin	28,35	glucose	insulin	MESH:D005947	493804(Tax:9685)	Chemical	Gene	concentrations|compound|START_ENTITY duration|nmod|concentrations have|dobj|duration have|nsubj|END_ENTITY	Glargine and protamine_zinc insulin have a longer duration of action and result in lower mean daily glucose concentrations than lente insulin in healthy cats .
18509807	0	glucose	129,136	insulin	39,46	glucose	insulin	MESH:D005947	3630	Chemical	Gene	fasting|dobj|START_ENTITY predict|advcl|fasting predict|nsubj|interaction interaction|nmod|response response|compound|END_ENTITY	The interaction between impaired acute insulin response and insulin resistance predict type 2 diabetes and impairment of fasting glucose .
1853796	0	glucose	25,32	insulin	65,72	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY deterioration|nmod|tolerance Review|dep|deterioration Review|dep|role role|nmod|resistance resistance|compound|END_ENTITY	Review : deterioration of glucose tolerance with age : the role of insulin resistance .
18544104	0	glucose	107,114	insulin	22,29	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY secretion|nmod|tolerance secretion|nsubj|Relationships Relationships|nmod|END_ENTITY	Relationships between insulin secretion after intravenous and oral glucose administration in subjects with glucose tolerance ranging from normal to overt diabetes .
18544104	0	glucose	67,74	insulin	22,29	glucose	insulin	MESH:D005947	3630	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Relationships Relationships|nmod|END_ENTITY	Relationships between insulin secretion after intravenous and oral glucose administration in subjects with glucose tolerance ranging from normal to overt diabetes .
18575277	0	glucose	31,38	insulin	150,157	glucose	insulin	MESH:D005947	3630	Chemical	Gene	levels|compound|START_ENTITY Differences|nmod|levels Differences|dep|role role|nmod|secretion secretion|compound|END_ENTITY	Differences in postload plasma glucose levels between 100-g and 75-g oral glucose tolerance tests in normal pregnant women : a potential role of early insulin secretion .
18575277	0	glucose	74,81	insulin	150,157	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tests|compound|START_ENTITY levels|nmod|tests Differences|nmod|levels Differences|dep|role role|nmod|secretion secretion|compound|END_ENTITY	Differences in postload plasma glucose levels between 100-g and 75-g oral glucose tolerance tests in normal pregnant women : a potential role of early insulin secretion .
18577787	0	glucose	122,129	insulin	66,73	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY degrees|nmod|tolerance using|nmod|degrees using|dobj|measurement measurement|nmod|resistance resistance|compound|END_ENTITY	Factor analysis of metabolic_syndrome using direct measurement of insulin resistance in Chinese with different degrees of glucose tolerance .
18611975	0	glucose	10,17	insulin	103,110	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY protamine|nsubj|metabolism protamine|dobj|END_ENTITY	Nocturnal glucose metabolism after bedtime injection of insulin glargine or neutral protamine hagedorn insulin in patients with type 2 diabetes .
18611975	0	glucose	10,17	insulin	56,63	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|nmod|injection injection|nmod|END_ENTITY	Nocturnal glucose metabolism after bedtime injection of insulin glargine or neutral protamine hagedorn insulin in patients with type 2 diabetes .
18670752	0	glucose	22,29	insulin	59,66	glucose	insulin	MESH:D005947	3630	Chemical	Gene	interpretation|nmod|START_ENTITY clamp|nsubj|interpretation clamp|dobj|studies studies|nmod|analogues analogues|compound|END_ENTITY	The interpretation of glucose clamp studies of long-acting insulin analogues : from physiology to marketing and back .
18682704	0	glucose	47,54	insulin	90,97	glucose	insulin	MESH:D005947	3630	Chemical	Gene	challenge|compound|START_ENTITY response|nmod|challenge profiling|nmod|response reveals|nsubj|profiling reveals|dobj|axes axes|nmod|sensitivity sensitivity|compound|END_ENTITY	Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity .
18726828	0	glucose	157,164	insulin	17,24	glucose	insulin	MESH:D005947	3630	Chemical	Gene	homeostasis|compound|START_ENTITY course|nmod|homeostasis Deconvolution|dep|course Deconvolution|nmod|rates rates|compound|END_ENTITY	Deconvolution of insulin secretion , insulin hepatic extraction post-hepatic delivery rates and sensitivity during 24-hour standardized meals : time course of glucose homeostasis in leptin replacement treatment .
18726828	0	glucose	157,164	insulin	36,43	glucose	insulin	MESH:D005947	3630	Chemical	Gene	homeostasis|compound|START_ENTITY course|nmod|homeostasis Deconvolution|dep|course Deconvolution|nmod|rates rates|compound|END_ENTITY	Deconvolution of insulin secretion , insulin hepatic extraction post-hepatic delivery rates and sensitivity during 24-hour standardized meals : time course of glucose homeostasis in leptin replacement treatment .
1874392	0	glucose	44,51	insulin	19,26	glucose	insulin	MESH:D005947	280829(Tax:9913)	Chemical	Gene	uptake|nmod|START_ENTITY vitro|nmod|uptake vitro|dobj|effect effect|nmod|END_ENTITY	In vitro effect of insulin on the uptake of glucose and alpha-aminoisobutyric_acid in the thyroid gland of the turtle -LRB- Chrysemys dorbigni -RRB- .
1874934	0	glucose	19,26	insulin	84,91	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY effects|nmod|metabolism effects|dep|evidence evidence|nmod|resistance resistance|compound|END_ENTITY	Insulin effects on glucose and potassium metabolism in vivo : evidence for selective insulin resistance in humans .
18768235	0	glucose	11,18	insulin	80,87	glucose	insulin	MESH:D005947	3630	Chemical	Gene	indicator|nsubj|START_ENTITY indicator|nmod|END_ENTITY	Is fasting glucose level during oral glucose tolerance test an indicator of the insulin need in gestational diabetes ?
18768235	0	glucose	37,44	insulin	80,87	glucose	insulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY level|nmod|test indicator|dep|level indicator|nmod|END_ENTITY	Is fasting glucose level during oral glucose tolerance test an indicator of the insulin need in gestational diabetes ?
18855718	0	glucose	100,107	insulin	22,29	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY signaling|nmod|metabolism crosstalk|acl|signaling crosstalk|nmod|END_ENTITY	The crosstalk between insulin and renin-angiotensin-aldosterone signaling systems and its effect on glucose metabolism and diabetes prevention .
1895958	0	glucose	42,49	insulin	8,15	glucose	insulin	MESH:D005947	3630	Chemical	Gene	uptake|compound|START_ENTITY uptake|amod|END_ENTITY	Forearm insulin - and non-insulin-mediated glucose uptake and muscle metabolism in man : role of free fatty_acids and blood glucose levels .
19024537	0	glucose	63,70	insulin	130,137	glucose	insulin	MESH:D005947	3630	Chemical	Gene	system|compound|START_ENTITY detected|nmod|system Evaluating|dep|detected Evaluating|nsubj|infusion infusion|compound|END_ENTITY	-LSB- Evaluating the feature of hypoglycemia detected by continuous glucose monitoring system during temporary continuous subcutaneous insulin infusion in type 2 diabetes patients -RSB- .
19040082	0	glucose	114,121	insulin	11,18	glucose	insulin	MESH:D005947	280829(Tax:9913)	Chemical	Gene	-RSB-|compound|START_ENTITY exposed|nmod|-RSB- exposed|nsubj|Effect Effect|nmod|END_ENTITY	-LSB- Effect of insulin on VEGF expression in bovine retinal microvascular endothelial cells exposed to normal or high glucose -RSB- .
19049377	0	glucose	119,126	insulin	89,96	glucose	insulin	MESH:D005947	3630	Chemical	Gene	clamp|amod|START_ENTITY properties|dep|clamp properties|nmod|formulations formulations|nmod|aspart aspart|compound|END_ENTITY	The pharmacokinetic and pharmacodynamic properties of different formulations of biphasic insulin aspart : a randomized , glucose clamp , crossover study .
19049379	0	glucose	20,27	insulin	112,119	glucose	insulin	MESH:D005947	3630	Chemical	Gene	stability|compound|START_ENTITY postprandial|dobj|stability postprandial|advcl|lispro lispro|compound|END_ENTITY	Better postprandial glucose stability during continuous subcutaneous infusion with insulin aspart compared with insulin lispro in patients with type 1 diabetes .
19049379	0	glucose	20,27	insulin	83,90	glucose	insulin	MESH:D005947	3630	Chemical	Gene	stability|compound|START_ENTITY postprandial|dobj|stability postprandial|nmod|infusion infusion|nmod|aspart aspart|compound|END_ENTITY	Better postprandial glucose stability during continuous subcutaneous infusion with insulin aspart compared with insulin lispro in patients with type 1 diabetes .
19056613	0	glucose	92,99	insulin	19,26	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY progression|nmod|tolerance secretion|nmod|progression secretion|nsubj|history history|nmod|sensitivity sensitivity|compound|END_ENTITY	Natural history of insulin sensitivity and insulin secretion in the progression from normal glucose tolerance to impaired fasting glycemia and impaired_glucose_tolerance : the Inter99 study .
1906584	0	glucose	55,62	insulin	16,23	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY combined|nmod|metabolism combined|csubj|-LSB- -LSB-|dobj|effects effects|nmod|END_ENTITY	-LSB- The effects of insulin combined with glibenclamide on glucose and lipid metabolism in patients with Type_II_diabetes_mellitus -RSB- .
19067533	0	glucose	23,30	insulin	78,85	glucose	insulin	MESH:D005947	3630	Chemical	Gene	fasting|dobj|START_ENTITY fasting|advcl|identifying identifying|dobj|resistance resistance|compound|END_ENTITY	The product of fasting glucose and triglycerides as surrogate for identifying insulin resistance in apparently healthy subjects .
19141955	0	glucose	89,96	insulin	14,21	glucose	insulin	MESH:D005947	3630	Chemical	Gene	amounts|nmod|START_ENTITY secretion|nmod|amounts secretion|nsubj|Evaluation Evaluation|nmod|END_ENTITY	Evaluation of insulin secretion by pancreatic cells in response to increasing amounts of glucose .
19164337	0	glucose	158,165	insulin	96,103	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY subjects|nmod|tolerance assessment|nmod|subjects improvement|nmod|assessment improvement|nmod|indices indices|nmod|sensitivity sensitivity|compound|END_ENTITY	Serum insulin-like_growth_factor_binding_protein-1 : an improvement over other simple indices of insulin sensitivity in the assessment of subjects with normal glucose tolerance .
19214472	10	glucose	1426,1433	insulin	1439,1446	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	Treatment|nmod|START_ENTITY Treatment|nmod|END_ENTITY	Treatment of beta cells chronically exposed to high glucose with insulin reduced beta cell apoptosis .
19234050	0	glucose	61,68	insulin	80,87	glucose	insulin	MESH:D005947	3630	Chemical	Gene	START_ENTITY|acl|stimulated stimulated|dobj|release release|compound|END_ENTITY	HIV-1 protease inhibitor induced oxidative stress suppresses glucose stimulated insulin release : protection with thymoquinone .
19251041	0	glucose	22,29	insulin	4,11	glucose	insulin	MESH:D005947	3630	Chemical	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	How insulin regulates glucose transport in adipocytes .
1928777	0	glucose	52,59	insulin	15,22	glucose	insulin	MESH:D005947	3630	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|infusion infusion|compound|END_ENTITY	The effects of insulin infusion on plasma and brain glucose in hyperglycemic diabetic rats .
19289105	0	glucose	98,105	insulin	115,122	glucose	insulin	MESH:D005947	3630	Chemical	Gene	entry|compound|START_ENTITY halts|dobj|entry halts|nmod|END_ENTITY	YM201636 , an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns -LRB- 3,5 -RRB- P2 synthesis , halts glucose entry by insulin in adipocytes .
19320663	0	glucose	98,105	insulin	58,65	glucose	insulin	MESH:D005947	3630	Chemical	Gene	variability|compound|START_ENTITY END_ENTITY|nmod|variability	A randomized clinical trial comparing the effect of basal insulin and inhaled mealtime insulin on glucose variability and oxidative stress .
19356403	0	glucose	9,16	insulin	91,98	glucose	insulin	MESH:D005947	3630	Chemical	Gene	regulation|compound|START_ENTITY associated|nsubjpass|regulation associated|nmod|plaque plaque|dep|relationship relationship|nmod|resistance resistance|compound|END_ENTITY	Abnormal glucose regulation is associated with lipid-rich coronary plaque : relationship to insulin resistance .
19367171	0	glucose	46,53	insulin	12,19	glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY glargine|nmod|control glargine|nsubj|Efficacy Efficacy|nmod|END_ENTITY	Efficacy of insulin glargine in perioperative glucose control in type 2 diabetic patients .
19367171	2	glucose	399,406	insulin	328,335	glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY glucose-insulin-potassium|nmod|control checked|nmod|glucose-insulin-potassium checked|nmod|comparison comparison|nmod|glargine glargine|compound|END_ENTITY	We checked the effect of insulin glargine through the comparison of insulin glargine with glucose-insulin-potassium -LRB- GIK -RRB- on perioperative glucose control in insulin-treated type 2 diabetic patients .
19430760	0	glucose	61,68	insulin	41,48	glucose	insulin	MESH:D005947	3630	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	A genome-wide association scan for acute insulin response to glucose in Hispanic-Americans : the Insulin Resistance_Atherosclerosis Family Study -LRB- IRAS FS -RRB- .
19435472	0	glucose	33,40	insulin	81,88	glucose	insulin	MESH:D005947	3630	Chemical	Gene	variability|nmod|START_ENTITY real|dep|variability real|nmod|target target|nmod|therapy therapy|compound|END_ENTITY	Is reducing variability of blood glucose the real but hidden target of intensive insulin therapy ?
1955097	0	glucose	38,45	insulin	6,13	glucose	insulin	MESH:D005947	3630	Chemical	Gene	Acute|nmod|START_ENTITY Acute|dobj|response response|compound|END_ENTITY	Acute insulin response to intravenous glucose , glucagon and arginine in some subjects at risk for type 1 -LRB- insulin-dependent -RRB- diabetes mellitus .
19570393	0	glucose	132,139	insulin	114,121	glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY control|compound|END_ENTITY	-LSB- Effect of different ways of insulin infusion in parenteral_nutrition patients on activation and concentration of insulin and blood glucose control : a prospective randomized comparison study -RSB- .
19570393	0	glucose	132,139	insulin	29,36	glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY Effect|nmod|control Effect|nmod|ways ways|nmod|infusion infusion|compound|END_ENTITY	-LSB- Effect of different ways of insulin infusion in parenteral_nutrition patients on activation and concentration of insulin and blood glucose control : a prospective randomized comparison study -RSB- .
19572	0	glucose	88,95	insulin	34,41	glucose	insulin	MESH:D005947	3630	Chemical	Gene	infusion|compound|START_ENTITY following|dobj|infusion Fetal|xcomp|following Fetal|dobj|observations observations|compound|END_ENTITY	Fetal and maternal blood glucose , insulin and acid base observations following maternal glucose infusion .
19636533	0	glucose	64,71	insulin	93,100	glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY controlled|nmod|control controlled|nmod|therapy therapy|compound|END_ENTITY	A prospective randomised multi-centre controlled trial on tight glucose control by intensive insulin therapy in adult intensive care units : the Glucontrol study .
19656159	0	glucose	89,96	insulin	61,68	glucose	insulin	MESH:D005947	3630	Chemical	Gene	Evaluation|dep|START_ENTITY Evaluation|nmod|status status|nmod|people people|nmod|resistance resistance|compound|END_ENTITY	Evaluation of glycaemic status in young people with clinical insulin resistance ; fasting glucose , fasting insulin or an oral glucose tolerance test ?
1967767	1	glucose	118,125	insulin	238,245	glucose	insulin	MESH:D005947	3630	Chemical	Gene	excursions|compound|START_ENTITY excursions|acl|bolus bolus|dobj|injection injection|nmod|analogue analogue|compound|END_ENTITY	Postprandial plasma glucose excursions and plasma levels of free insulin after subcutaneous bolus injection of a rapidly absorbed monomeric insulin analogue -LRB- B9AspB27Glu -RRB- or soluble human insulin -LRB- ` Actrapid HM ' U100 -RRB- were studied in six insulin-treated diabetic subjects .
19700655	0	glucose	15,22	insulin	35,42	glucose	insulin	MESH:D005947	3630	Chemical	Gene	insulin|appos|START_ENTITY indices|nsubj|insulin indices|nmod|resistance resistance|compound|END_ENTITY	Serum insulin , glucose , indices of insulin resistance , and risk of prostate_cancer .
19797055	0	glucose	23,30	insulin	104,111	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY coupling|nmod|metabolism required|nsubjpass|coupling required|nmod|secretion secretion|compound|END_ENTITY	Tight coupling between glucose and mitochondrial metabolism in clonal beta-cells is required for robust insulin secretion .
1981340	0	glucose	45,52	insulin	10,17	glucose	insulin	MESH:D005947	397415(Tax:9823)	Chemical	Gene	transport|compound|START_ENTITY agonists|nmod|transport agonists|nsubj|Effect Effect|nmod|END_ENTITY	Effect of insulin and adrenergic agonists on glucose transport of porcine adipocytes .
19834875	0	glucose	39,46	insulin	115,122	glucose	insulin	MESH:D005947	3630	Chemical	Gene	levels|compound|START_ENTITY epidural|dobj|levels epidural|nmod|patients patients|acl|undergoing undergoing|dobj|cardiopulmonary_bypass cardiopulmonary_bypass|nmod|infusion infusion|compound|END_ENTITY	Thoracic epidural anesthesia and blood glucose levels in diabetic patients undergoing cardiopulmonary_bypass under insulin infusion according to the Portland protocol .
19847137	0	glucose	98,105	insulin	49,56	glucose	insulin	MESH:D005947	3630	Chemical	Gene	level|compound|START_ENTITY sufficient|nsubj|level profile|dep|sufficient profile|nmod|therapy therapy|compound|END_ENTITY	Glycemic profile and effectiveness and safety of insulin therapy in septic patients : is the blood glucose level sufficient ?
1988769	0	glucose	57,64	insulin	32,39	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of portal delivery of insulin on intracellular glucose and lipid metabolism .
19902049	0	glucose	100,107	insulin	9,16	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY degrees|nmod|tolerance subjects|nmod|degrees serum|nmod|subjects Study|acl|serum Study|nmod|resistance resistance|compound|END_ENTITY	Study of insulin resistance in relation to serum IGF-I levels in subjects with different degrees of glucose tolerance .
1991830	0	glucose	58,65	insulin	25,32	glucose	insulin	MESH:D005947	3630	Chemical	Gene	infusion|compound|START_ENTITY secretion|nmod|infusion secretion|nsubj|Entrainment Entrainment|nmod|END_ENTITY	Entrainment of pulsatile insulin secretion by oscillatory glucose infusion .
1999488	0	glucose	34,41	insulin	69,76	glucose	insulin	MESH:D005947	3630	Chemical	Gene	protein|compound|START_ENTITY suppression|nmod|protein causes|nsubj|suppression causes|dobj|resistance resistance|compound|END_ENTITY	Pretranslational suppression of a glucose transporter protein causes insulin resistance in adipocytes from patients with non-insulin-dependent_diabetes_mellitus and obesity .
20032280	0	glucose	39,46	insulin	13,20	glucose	insulin	MESH:D005947	3630	Chemical	Gene	using|dobj|START_ENTITY sensitivity|xcomp|using sensitivity|nsubj|Estimates Estimates|nmod|END_ENTITY	Estimates of insulin sensitivity using glucose and C-Peptide from the hyperglycemia and adverse pregnancy outcome glucose tolerance test .
20067967	0	glucose	23,30	insulin	39,46	glucose	insulin	MESH:D005947	3630	Chemical	Gene	load|compound|START_ENTITY load|nmod|END_ENTITY	Effects of intravenous glucose load on insulin secretion in patients with ketosis-prone_diabetes during near-normoglycemia remission .
2008651	0	glucose	52,59	insulin	30,37	glucose	insulin	MESH:D005947	3630	Chemical	Gene	uptake|compound|START_ENTITY effect|nmod|uptake effect|nmod|END_ENTITY	The effect of graded doses of insulin on peripheral glucose uptake and lactate release in cancer_cachexia .
20144330	0	glucose	52,59	insulin	104,111	glucose	insulin	MESH:D005947	397415(Tax:9823)	Chemical	Gene	study|nmod|START_ENTITY control|nsubj|study control|xcomp|using using|dobj|infusion infusion|nmod|END_ENTITY	A feasibility study of bihormonal closed-loop blood glucose control using dual subcutaneous infusion of insulin and glucagon in ambulatory diabetic swine .
20215457	0	glucose	162,169	insulin	103,110	glucose	insulin	MESH:D005947	3630	Chemical	Gene	levels|compound|START_ENTITY respond|nmod|levels infusion|acl|respond infusion|compound|END_ENTITY	Evaluation of an algorithm to guide patients with type 1 diabetes treated with continuous subcutaneous insulin infusion on how to respond to real-time continuous glucose levels : a randomized controlled trial .
20225188	0	glucose	100,107	insulin	45,52	glucose	insulin	MESH:D005947	3630	Chemical	Gene	individuals|nmod|START_ENTITY associated|nmod|individuals associated|nmod|secretion secretion|compound|END_ENTITY	Pancreatic fat is negatively associated with insulin secretion in individuals with impaired fasting glucose and/or impaired_glucose_tolerance : a nuclear magnetic resonance study .
20298586	0	glucose	100,107	insulin	59,66	glucose	insulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY Advantages|nmod|test Advantages|nmod|model model|nmod|assessment assessment|nmod|sensitivity sensitivity|compound|END_ENTITY	Advantages of the single delay model for the assessment of insulin sensitivity from the intravenous glucose tolerance test .
20371732	0	glucose	83,90	insulin	124,131	glucose	insulin	MESH:D005947	397415(Tax:9823)	Chemical	Gene	infusate|compound|START_ENTITY labeled|dobj|infusate labeled|nmod|assessment assessment|nmod|resistance resistance|compound|END_ENTITY	Hyperinsulinemic euglycemic step clamping with tracer glucose infusion and labeled glucose infusate for assessment of acute insulin resistance in pigs .
20380653	0	glucose	110,117	insulin	142,149	glucose	insulin	MESH:D005947	3630	Chemical	Gene	secretion|compound|START_ENTITY secretion|compound|END_ENTITY	Twelve weeks treatment with the DPP-4 inhibitor , sitagliptin , prevents degradation of peptide_YY and improves glucose and non-glucose induced insulin secretion in patients with type_2_diabetes_mellitus .
20461354	0	glucose	116,123	insulin	127,134	glucose	insulin	MESH:D005947	3630	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Subplasmalemmal Ca -LRB- 2 + -RRB- measurements in mouse pancreatic beta cells support the existence of an amplifying effect of glucose on insulin secretion .
20464705	0	glucose	27,34	insulin	87,94	glucose	insulin	MESH:D005947	3630	Chemical	Gene	transport|compound|START_ENTITY Investigations|nmod|transport Investigations|nmod|influence influence|nmod|END_ENTITY	Investigations of cellular glucose transport and its regulation under the influence of insulin in human peripheral blood lymphocytes .
20496226	0	glucose	6,13	insulin	67,74	glucose	insulin	MESH:D005947	3630	Chemical	Gene	responses|compound|START_ENTITY responses|nmod|reductions reductions|nmod|END_ENTITY	Blood glucose responses to reductions in pre-exercise rapid-acting insulin for 24 h after running in individuals with type 1 diabetes .
20498658	0	glucose	49,56	insulin	32,39	glucose	insulin	MESH:D005947	3630	Chemical	Gene	uptake|compound|START_ENTITY END_ENTITY|dobj|uptake	Fat mass largely contributes to insulin mediated glucose uptake in morbidly obese subjects .
20507559	0	glucose	42,49	insulin	14,21	glucose	insulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY resistance|nmod|test resistance|compound|END_ENTITY	Assessment of insulin resistance by a 13C glucose breath test : a new tool for early diagnosis and follow-up of high-risk patients .
2051553	0	glucose	52,59	insulin	20,27	glucose	insulin	MESH:D005947	3630	Chemical	Gene	infusion|compound|START_ENTITY enhance|nmod|infusion enhance|dobj|resistance resistance|compound|END_ENTITY	Amino_acids enhance insulin resistance to exogenous glucose infusion in overnight-fasted humans .
20517591	0	glucose	103,110	insulin	49,56	glucose	insulin	MESH:D005947	3630	Chemical	Gene	homeostasis|compound|START_ENTITY concentrations|nmod|homeostasis concentrations|compound|END_ENTITY	Recent population changes in HbA -LRB- 1c -RRB- and fasting insulin concentrations among US adults with preserved glucose homeostasis .
20609972	3	glucose	435,442	insulin	356,363	glucose	insulin	MESH:D005947	3630	Chemical	Gene	activity|compound|START_ENTITY defects|nmod|activity stems|nmod|defects stems|nsubj|resistance resistance|compound|END_ENTITY	However , work over the past two decades has shown that lipid-induced insulin resistance in skeletal muscle stems from defects in insulin-stimulated glucose transport activity .
2061244	0	glucose	26,33	insulin	63,70	glucose	insulin	MESH:D005947	280829(Tax:9913)	Chemical	Gene	responsiveness|compound|START_ENTITY responsiveness|nmod|responsiveness responsiveness|nmod|END_ENTITY	Insulin responsiveness to glucose and tissue responsiveness to insulin in lactating , pregnant , and nonpregnant , nonlactating beef cows .
2065473	0	glucose	11,18	insulin	20,27	glucose	insulin	MESH:D005947	3630	Chemical	Gene	interrelationships|advmod|START_ENTITY interrelationships|nsubj|END_ENTITY	Potassium , glucose , insulin interrelationships during adrenaline infusion in normotensive and hypertensive_humans .
2065854	0	glucose	32,39	insulin	55,62	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY value|nmod|tolerance test|nsubj|value test|dobj|secretion secretion|compound|END_ENTITY	Predictive value of intravenous glucose tolerance test insulin secretion less than or greater than the first percentile in islet cell antibody positive relatives of type 1 -LRB- insulin-dependent -RRB- diabetic patients .
20667567	0	glucose	60,67	insulin	51,58	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	hormone|dep|START_ENTITY hormone|compound|END_ENTITY	Influence of topical dexamethasone applications on insulin , glucose , thyroid hormone and cortisol levels in dogs .
20668044	0	glucose	79,86	insulin	15,22	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY Differences|nmod|tolerance Differences|nmod|resistance resistance|compound|END_ENTITY	Differences in insulin resistance in Mexican and U.S. Pima Indians with normal glucose tolerance .
20696267	0	glucose	47,54	insulin	8,15	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY Role|nmod|metabolism Role|nmod|END_ENTITY	Role of insulin and IGF-I on the regulation of glucose metabolism in European sea bass -LRB- Dicentrarchus labrax -RRB- fed with different dietary carbohydrate levels .
20699417	0	glucose	40,47	insulin	99,106	glucose	insulin	MESH:D005947	3630	Chemical	Gene	concentrations|compound|START_ENTITY concentrations|nmod|humans humans|nmod|levels levels|compound|END_ENTITY	Glucagon supports postabsorptive plasma glucose concentrations in humans with biologically optimal insulin levels .
20806184	0	glucose	42,49	insulin	87,94	glucose	insulin	MESH:D005947	3630	Chemical	Gene	utilization|compound|START_ENTITY regulator|nmod|utilization Insulin|nmod|regulator Insulin|dep|aspects aspects|nmod|resistance resistance|compound|END_ENTITY	Insulin as the main regulator of cellular glucose utilization -- aetiological aspects of insulin resistance .
20920437	0	glucose	148,155	insulin	15,22	glucose	insulin	MESH:D005947	3630	Chemical	Gene	levels|compound|START_ENTITY individuals|nmod|levels study|nmod|individuals using|nmod|study infusion|acl|using subcutaneous|dobj|infusion subcutaneous|nsubj|Guidelines Guidelines|nmod|END_ENTITY	Guidelines for insulin dosing in continuous subcutaneous insulin infusion using new formulas from a retrospective study of individuals with optimal glucose levels .
20920437	0	glucose	148,155	insulin	57,64	glucose	insulin	MESH:D005947	3630	Chemical	Gene	levels|compound|START_ENTITY individuals|nmod|levels study|nmod|individuals using|nmod|study infusion|acl|using infusion|compound|END_ENTITY	Guidelines for insulin dosing in continuous subcutaneous insulin infusion using new formulas from a retrospective study of individuals with optimal glucose levels .
20934485	0	glucose	62,69	insulin	49,56	glucose	insulin	MESH:D005947	3630	Chemical	Gene	measurement|compound|START_ENTITY estimates|nmod|measurement estimates|dobj|END_ENTITY	The Unscented Kalman Filter estimates the plasma insulin from glucose measurement .
20960276	0	glucose	97,104	insulin	53,60	glucose	insulin	MESH:D005947	3630	Chemical	Gene	SIRT1|nmod|START_ENTITY stimulated|nmod|SIRT1 stimulated|nmod|END_ENTITY	Effects of resveratrol on NO secretion stimulated by insulin and its dependence on SIRT1 in high glucose cultured endothelial cells .
2099998	0	glucose	111,118	insulin	76,83	glucose	insulin	MESH:D005947	3630	Chemical	Gene	-RSB-|compound|START_ENTITY glucose|nmod|-RSB- glucose|nmod|assessment assessment|nmod|resistance resistance|compound|END_ENTITY	-LSB- Use of an automatic blood glucose measurement system for the assessment of insulin resistance during the oral glucose tolerance test -RSB- .
2099998	0	glucose	27,34	insulin	76,83	glucose	insulin	MESH:D005947	3630	Chemical	Gene	START_ENTITY|nmod|assessment assessment|nmod|resistance resistance|compound|END_ENTITY	-LSB- Use of an automatic blood glucose measurement system for the assessment of insulin resistance during the oral glucose tolerance test -RSB- .
21059029	0	glucose	55,62	insulin	81,88	glucose	insulin	MESH:D005947	100060077(Tax:9796)	Chemical	Gene	solution|compound|START_ENTITY solution|nmod|END_ENTITY	Effects of leucine or whey protein addition to an oral glucose solution on serum insulin , plasma glucose and plasma amino_acid responses in horses at rest and following exercise .
21062674	0	glucose	99,106	insulin	38,45	glucose	insulin	MESH:D005947	3630	Chemical	Gene	variability|compound|START_ENTITY END_ENTITY|nmod|variability	The impact of continuous subcutaneous insulin infusion and multiple_daily_injections_of_insulin on glucose variability in older adults with type 2 diabetes .
21112995	0	glucose	31,38	insulin	11,18	glucose	insulin	MESH:D005947	280829(Tax:9913)	Chemical	Gene	homeostasis|compound|START_ENTITY infusion|nmod|homeostasis infusion|compound|END_ENTITY	Effects of insulin infusion on glucose homeostasis and glucose metabolism in rainbow_trout fed a high-carbohydrate diet .
21129338	0	glucose	62,69	insulin	22,29	glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY infusion|nmod|control infusion|compound|END_ENTITY	Combining basal-bolus insulin infusion for tight postprandial glucose control : an in silico evaluation in adults , children , and adolescents .
21211306	0	glucose	52,59	insulin	97,104	glucose	insulin	MESH:D005947	3630	Chemical	Gene	level|compound|START_ENTITY nocturnal_hypoglycaemia|nmod|level Prediction|nmod|nocturnal_hypoglycaemia subcutaneous|nsubj|Prediction subcutaneous|dobj|infusion infusion|compound|END_ENTITY	-LSB- Prediction of nocturnal_hypoglycaemia with bedtime glucose level during continuous subcutaneous insulin infusion in type 2 diabetics -RSB- .
2121567	0	glucose	78,85	insulin	10,17	glucose	insulin	MESH:D005947	3630	Chemical	Gene	derived|dobj|START_ENTITY derived|nsubj|Effect Effect|nmod|END_ENTITY	Effect of insulin on oxidation of intracellularly and extracellularly derived glucose in patients with NIDDM .
21248305	0	glucose	122,129	insulin	18,25	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY degree|nmod|tolerance relationship|nmod|degree Shape|dep|relationship Shape|appos|END_ENTITY	Shape of glucose , insulin , C-peptide curves during a 3-h oral glucose tolerance test : any relationship with the degree of glucose tolerance ?
21248305	0	glucose	62,69	insulin	18,25	glucose	insulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY curves|nmod|test Shape|appos|curves Shape|appos|END_ENTITY	Shape of glucose , insulin , C-peptide curves during a 3-h oral glucose tolerance test : any relationship with the degree of glucose tolerance ?
21248305	0	glucose	9,16	insulin	18,25	glucose	insulin	MESH:D005947	3630	Chemical	Gene	Shape|nmod|START_ENTITY Shape|appos|END_ENTITY	Shape of glucose , insulin , C-peptide curves during a 3-h oral glucose tolerance test : any relationship with the degree of glucose tolerance ?
21270256	0	glucose	28,35	insulin	11,18	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY Effects|nmod|metabolism Effects|nmod|END_ENTITY	Effects of insulin on brain glucose metabolism in impaired_glucose_tolerance .
21276273	11	glucose	1407,1414	insulin	1387,1394	glucose	insulin	MESH:D005947	3630	Chemical	Gene	resistance|dep|START_ENTITY resistance|compound|END_ENTITY	On admission , 62 % of the hyperglycemic children had overt insulin resistance -LRB- glucose > 8.3 mmol/l and HOMA - % S < 50 % -RRB- ; 17 % had b-cell dysfunction -LRB- glucose > 8.3 mmol/l and HOMA - % B < 50 % -RRB- and 21 % had both insulin resistance and b-cell dysfunction .
21278138	0	glucose	18,25	insulin	130,137	glucose	insulin	MESH:D005947	3630	Chemical	Gene	monitoring|compound|START_ENTITY monitoring|nmod|subjects subjects|nmod|diabetes diabetes|nmod|multiple_daily_injections multiple_daily_injections|nmod|END_ENTITY	Use of continuous glucose monitoring in subjects with type 1 diabetes on multiple_daily_injections versus continuous subcutaneous insulin infusion therapy : a prospective 6-month study .
21297886	0	glucose	26,33	insulin	36,43	glucose	insulin	MESH:D005947	3630	Chemical	Gene	system|compound|START_ENTITY system|compound|END_ENTITY	Enhanced modelling of the glucose insulin system and its applications in insulin therapies .
21297886	0	glucose	26,33	insulin	75,82	glucose	insulin	MESH:D005947	3630	Chemical	Gene	system|compound|START_ENTITY modelling|nmod|system modelling|nmod|therapies therapies|compound|END_ENTITY	Enhanced modelling of the glucose insulin system and its applications in insulin therapies .
21356519	0	glucose	72,79	insulin	9,16	glucose	insulin	MESH:D005947	3630	Chemical	Gene	uptake|compound|START_ENTITY reduces|dobj|uptake reduces|nsubj|END_ENTITY	Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle .
21367930	0	glucose	46,53	insulin	14,21	glucose	insulin	MESH:D005947	3630	Chemical	Gene	feedback|nmod|START_ENTITY feedback|compound|END_ENTITY	The effect of insulin feedback on closed loop glucose control .
21376417	0	glucose	42,49	insulin	96,103	glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY Nateglinide|nmod|control Nateglinide|advcl|optimizing optimizing|nmod|glargine glargine|compound|END_ENTITY	Nateglinide and acarbose for postprandial glucose control after optimizing fasting glucose with insulin glargine in patients with type 2 diabetes .
21376417	0	glucose	83,90	insulin	96,103	glucose	insulin	MESH:D005947	3630	Chemical	Gene	optimizing|dobj|START_ENTITY optimizing|nmod|glargine glargine|compound|END_ENTITY	Nateglinide and acarbose for postprandial glucose control after optimizing fasting glucose with insulin glargine in patients with type 2 diabetes .
2137755	0	glucose	59,66	insulin	15,22	glucose	insulin	MESH:D005947	3630	Chemical	Gene	disposal|compound|START_ENTITY increases|dobj|disposal increases|nsubj|Combination Combination|nmod|END_ENTITY	Combination of insulin with glipizide increases peripheral glucose disposal in secondary failure type 2 diabetic patients .
2139397	0	glucose	12,19	insulin	50,57	glucose	insulin	MESH:D005947	3630	Chemical	Gene	method|compound|START_ENTITY method|acl|using using|dobj|infusion infusion|compound|END_ENTITY	An unbiased glucose clamp method using a variable insulin infusion : its application in diabetic adolescents .
21437134	0	glucose	79,86	insulin	41,48	glucose	insulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY reduces|nmod|test reduces|dobj|secretion secretion|compound|END_ENTITY	Amantadine reduces glucagon and enhances insulin secretion throughout the oral glucose tolerance test : central plus peripheral nervous system mechanisms .
21448693	0	glucose	104,111	insulin	12,19	glucose	insulin	MESH:D005947	3630	Chemical	Gene	data|compound|START_ENTITY interpretation|nmod|data assessment|nmod|interpretation Dynamics|dep|assessment Dynamics|nmod|action action|compound|END_ENTITY	Dynamics of insulin action in hypertension : assessment from minimal model interpretation of intravenous glucose tolerance test data .
2146285	0	glucose	92,99	insulin	32,39	glucose	insulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY secretion|nmod|test secretion|nsubj|response response|nmod|END_ENTITY	Androgen response to endogenous insulin secretion during the frequently sampled intravenous glucose tolerance test in normal and hyperandrogenic women .
21508130	0	glucose	80,87	insulin	23,30	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY spectrum|nmod|tolerance youth|nmod|spectrum sensitivity|nmod|youth sensitivity|nsubj|estimates estimates|nmod|END_ENTITY	Surrogate estimates of insulin sensitivity in obese youth along the spectrum of glucose tolerance from normal to prediabetes to diabetes .
21575079	0	glucose	73,80	insulin	64,71	glucose	insulin	MESH:D005947	3630	Chemical	Gene	triglyceride|dep|START_ENTITY triglyceride|compound|END_ENTITY	Effects of high and moderate non-structural carbohydrate hay on insulin , glucose , triglyceride , and leptin concentrations in overweight Arabian geldings .
21604201	2	glucose	367,374	insulin	308,315	glucose	insulin	MESH:D005947	3630	Chemical	Gene	GLUT4|compound|START_ENTITY activity|nmod|GLUT4 associated|nmod|activity associated|nsubjpass|action action|compound|END_ENTITY	While the etiology of insulin resistance is multifactorial , reduced insulin action is associated with impaired activity of the glucose transporter GLUT4 in insulin-sensitive tissues .
21680998	0	glucose	24,31	insulin	44,51	glucose	insulin	MESH:D005947	3630	Chemical	Gene	levels|compound|START_ENTITY Control|nmod|levels Control|nmod|END_ENTITY	Control of postprandial glucose levels with insulin in type 2 diabetes .
21734082	0	glucose	32,39	insulin	14,21	glucose	insulin	MESH:D005947	3630	Chemical	Gene	action|nmod|START_ENTITY action|compound|END_ENTITY	Comparison of insulin action on glucose versus potassium uptake in humans .
21772735	0	glucose	24,31	insulin	32,39	glucose	insulin	MESH:D005947	3630	Chemical	Gene	START_ENTITY|dobj|levels levels|compound|END_ENTITY	Efficacy of 2-hour post glucose insulin levels in predicting insulin resistance in polycystic_ovarian_syndrome with infertility .
21772735	0	glucose	24,31	insulin	61,68	glucose	insulin	MESH:D005947	3630	Chemical	Gene	START_ENTITY|advcl|predicting predicting|dobj|resistance resistance|compound|END_ENTITY	Efficacy of 2-hour post glucose insulin levels in predicting insulin resistance in polycystic_ovarian_syndrome with infertility .
2177367	0	glucose	138,145	insulin	14,21	glucose	insulin	MESH:D005947	3630	Chemical	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|secretion secretion|compound|END_ENTITY	Comparison of insulin secretion and insulin sensitivity between normal and impaired_glucose_tolerance subjects with normal fasting plasma glucose .
21792327	0	glucose	109,116	insulin	32,39	glucose	insulin	MESH:D005947	3630	Chemical	Gene	monitoring|compound|START_ENTITY using|dobj|monitoring therapy|acl|using detemir|nmod|therapy detemir|nsubj|comparison comparison|nmod|glargine glargine|compound|END_ENTITY	Two-way crossover comparison of insulin glargine and insulin detemir in basal-bolus therapy using continuous glucose monitoring .
21803140	0	glucose	91,98	insulin	64,71	glucose	insulin	MESH:D005947	3630	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|sulfobutyl_ether-b-cyclodextrin sulfobutyl_ether-b-cyclodextrin|nmod|bioavailability bioavailability|nmod|glargine glargine|compound|END_ENTITY	Effect of sulfobutyl_ether-b-cyclodextrin on bioavailability of insulin glargine and blood glucose level after subcutaneous injection to rats .
21818569	0	glucose	29,36	insulin	130,137	glucose	insulin	MESH:D005947	3630	Chemical	Gene	Evaluation|nmod|START_ENTITY metabolism|nsubj|Evaluation metabolism|nmod|model model|nmod|resistance resistance|compound|END_ENTITY	Evaluation of organ-specific glucose metabolism by F-FDG in insulin_receptor_substrate-1 -LRB- IRS-1 -RRB- knockout mice as a model of insulin resistance .
21854193	0	glucose	163,170	insulin	36,43	glucose	insulin	MESH:D005947	3630	Chemical	Gene	patterns|compound|START_ENTITY analysis|nmod|patterns Comparison|dep|analysis Comparison|nmod|therapy therapy|compound|END_ENTITY	Comparison between sensor-augmented insulin therapy with continuous subcutaneous insulin infusion or multiple_daily_injections in everyday life : 3-day analysis of glucose patterns and sensor accuracy in children .
21854193	0	glucose	163,170	insulin	81,88	glucose	insulin	MESH:D005947	3630	Chemical	Gene	patterns|compound|START_ENTITY analysis|nmod|patterns Comparison|dep|analysis Comparison|nmod|therapy therapy|nmod|infusion infusion|compound|END_ENTITY	Comparison between sensor-augmented insulin therapy with continuous subcutaneous insulin infusion or multiple_daily_injections in everyday life : 3-day analysis of glucose patterns and sensor accuracy in children .
2185935	0	glucose	52,59	insulin	84,91	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	control|compound|START_ENTITY control|nmod|diabetes diabetes|compound|END_ENTITY	Insulin therapy on the peritoneal route : effects on glucose control in experimental insulin dependent diabetes .
21864748	0	glucose	41,48	insulin	20,27	glucose	insulin	MESH:D005947	3630	Chemical	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	The dual control of insulin secretion by glucose involves triggering and amplifying pathways in b-cells .
21865650	0	glucose	11,18	insulin	43,50	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	homeostasis|compound|START_ENTITY homeostasis|dep|matter matter|nsubj|END_ENTITY	Peripheral glucose homeostasis : does brain insulin matter ?
21939115	0	glucose	56,63	insulin	65,72	glucose	insulin	MESH:D005947	3630	Chemical	Gene	-LSB-|nmod|START_ENTITY -RSB-|advcl|-LSB- -RSB-|nsubj|levels levels|compound|END_ENTITY	-LSB- The influence of single immersion in Dead Sea water on glucose , insulin , cortisol and C-peptide levels in type_2_diabetes_mellitus patients -RSB- .
2195099	0	glucose	4,11	insulin	73,80	glucose	insulin	MESH:D005947	3630	Chemical	Gene	technique|compound|START_ENTITY technique|dep|resistance resistance|compound|END_ENTITY	The glucose clamp technique for the study of patients with hypoglycemia : insulin resistance as a feature of insulinoma .
21960076	0	glucose	25,32	insulin	102,109	glucose	insulin	MESH:D005947	3630	Chemical	Gene	Association|nmod|START_ENTITY level|nsubj|Association level|nmod|fetal-maternal_complications_of_gestational_diabetes fetal-maternal_complications_of_gestational_diabetes|nmod|therapy therapy|compound|END_ENTITY	Association of the serum glucose level with fetal-maternal_complications_of_gestational_diabetes with insulin therapy .
21973241	0	glucose	36,43	insulin	240,247	glucose	insulin	MESH:D005947	3630	Chemical	Gene	profiles|nmod|START_ENTITY fatty_acid|nsubj|profiles fatty_acid|dobj|evidence evidence|nmod|effects effects|nmod|secretion secretion|compound|END_ENTITY	Twenty-four-hour profiles of plasma glucose , insulin , C-peptide and free fatty_acid in subjects with varying degrees of glucose_tolerance following short-term , medium-dose prednisone -LRB- 20 mg/day -RRB- treatment : evidence for differing effects on insulin secretion and action .
2199967	0	glucose	115,122	insulin	79,86	glucose	insulin	MESH:D005947	3630	Chemical	Gene	stimulation|compound|START_ENTITY secretion|nmod|stimulation secretion|nsubj|Influence Influence|nmod|naloxone naloxone|nmod|augmentation augmentation|nmod|END_ENTITY	Influence of naloxone , atropine , and metoclopramide on ethanol augmentation of insulin secretion after intravenous glucose stimulation .
22004512	0	glucose	34,41	insulin	61,68	glucose	insulin	MESH:D005947	3630	Chemical	Gene	load|compound|START_ENTITY load|nmod|END_ENTITY	Effects of variations in duodenal glucose load on glycaemic , insulin , and incretin responses in type 2 diabetes .
22013886	0	glucose	75,82	insulin	143,150	glucose	insulin	MESH:D005947	3630	Chemical	Gene	comparable|nmod|START_ENTITY comparable|nmod|diabetes diabetes|acl|titrating titrating|dobj|injection injection|nmod|study study|compound|END_ENTITY	Telecare Provides comparable efficacy to conventional self-monitored blood glucose in patients with type 2 diabetes titrating one injection of insulin glulisine-the ELEONOR study .
22023376	0	glucose	176,183	insulin	102,109	glucose	insulin	MESH:D005947	3630	Chemical	Gene	modeling|compound|START_ENTITY data|nmod|modeling collection|nmod|data Effects|dep|collection Effects|nmod|type_1_diabetes type_1_diabetes|compound|END_ENTITY	Effects of everyday life events on glucose , insulin , and glucagon dynamics in continuous subcutaneous insulin infusion-treated type_1_diabetes : collection of clinical data for glucose modeling .
22023376	0	glucose	176,183	insulin	44,51	glucose	insulin	MESH:D005947	3630	Chemical	Gene	modeling|compound|START_ENTITY data|nmod|modeling collection|nmod|data Effects|dep|collection Effects|nmod|events events|nmod|END_ENTITY	Effects of everyday life events on glucose , insulin , and glucagon dynamics in continuous subcutaneous insulin infusion-treated type_1_diabetes : collection of clinical data for glucose modeling .
22023376	0	glucose	35,42	insulin	102,109	glucose	insulin	MESH:D005947	3630	Chemical	Gene	insulin|compound|START_ENTITY events|nmod|insulin Effects|nmod|events Effects|nmod|type_1_diabetes type_1_diabetes|compound|END_ENTITY	Effects of everyday life events on glucose , insulin , and glucagon dynamics in continuous subcutaneous insulin infusion-treated type_1_diabetes : collection of clinical data for glucose modeling .
2203384	3	glucose	613,620	insulin	553,560	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY those|nmod|tolerance severe|nmod|those severe|nsubj|resistance resistance|compound|END_ENTITY	In individuals with impaired_glucose_tolerance , insulin resistance is more severe than in those with normal glucose tolerance .
22056597	0	glucose	15,22	insulin	49,56	glucose	insulin	MESH:D005947	3630	Chemical	Gene	uptake|compound|START_ENTITY Stimulation|nmod|uptake Stimulation|nmod|resistance resistance|compound|END_ENTITY	Stimulation of glucose uptake and improvement of insulin resistance by aromadendrin .
2210065	0	glucose	84,91	insulin	20,27	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	regulation|nmod|START_ENTITY route|nmod|regulation route|compound|END_ENTITY	Interaction between insulin and glucose-delivery route in regulation of net hepatic glucose uptake in conscious dogs .
22181063	0	glucose	98,105	insulin	145,152	glucose	insulin	MESH:D005947	3630	Chemical	Gene	system|compound|START_ENTITY system|acl|comparing comparing|dobj|use use|nmod|glargine glargine|compound|END_ENTITY	Glucose control in acute_myocardial_infarction : a pilot randomized study controlled by continuous glucose monitoring system comparing the use of insulin glargine with standard of care .
22227186	0	glucose	33,40	insulin	104,111	glucose	insulin	MESH:D005947	3630	Chemical	Gene	START_ENTITY|nmod|peak peak|nmod|release release|acl|followed followed|nmod|pulses pulses|nmod|END_ENTITY	Isolated mouse islets respond to glucose with an initial peak of glucagon release followed by pulses of insulin and somatostatin in antisynchrony with glucagon .
22235952	0	glucose	33,40	insulin	83,90	glucose	insulin	MESH:D005947	3630	Chemical	Gene	Cost|nmod|START_ENTITY Cost|nmod|patients patients|nmod|regimen regimen|compound|END_ENTITY	Cost of self-monitoring of blood glucose in the United States among patients on an insulin regimen for diabetes .
22242005	0	glucose	60,67	insulin	29,36	glucose	insulin	MESH:D005947	42549(Tax:7227)	Chemical	Gene	metabolism|compound|START_ENTITY control|dobj|metabolism regulates|advcl|control regulates|dobj|sensitivity sensitivity|compound|END_ENTITY	MAPK/ERK signaling regulates insulin sensitivity to control glucose metabolism in Drosophila .
22244505	0	glucose	36,43	insulin	11,18	glucose	insulin	MESH:D005947	3630	Chemical	Gene	levels|compound|START_ENTITY sensitivity|nmod|levels sensitivity|compound|END_ENTITY	Estimating insulin sensitivity from glucose levels only : Use of a non-linear mixed effects approach and maximum a posteriori -LRB- MAP -RRB- estimation .
2227125	0	glucose	120,127	insulin	11,18	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	transport|compound|START_ENTITY signaling|nmod|transport Effects|acl|signaling Effects|nmod|END_ENTITY	Effects of insulin on diacylglycerol-protein_kinase_C signaling in rat diaphragm and soleus muscles and relationship to glucose transport .
2229300	0	glucose	23,30	insulin	66,73	glucose	insulin	MESH:D005947	3630	Chemical	Gene	levels|compound|START_ENTITY fasting|dobj|levels fasting|nmod|secretion secretion|nmod|END_ENTITY	Association of fasting glucose levels with a delayed secretion of insulin after oral glucose in subjects with glucose_intolerance .
2229300	0	glucose	85,92	insulin	66,73	glucose	insulin	MESH:D005947	3630	Chemical	Gene	fasting|nmod|START_ENTITY fasting|nmod|secretion secretion|nmod|END_ENTITY	Association of fasting glucose levels with a delayed secretion of insulin after oral glucose in subjects with glucose_intolerance .
22345552	0	glucose	73,80	insulin	126,133	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY improves|dobj|tolerance improves|nmod|model model|nmod|resistance resistance|compound|END_ENTITY	Ezetimibe ameliorates intestinal chylomicron overproduction and improves glucose tolerance in a diet-induced hamster model of insulin resistance .
22372347	0	glucose	77,84	insulin	45,52	glucose	insulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY measurement|nmod|test measurement|compound|END_ENTITY	Hemolysis is a major cause of variability in insulin measurement during oral glucose tolerance test in children .
22386942	0	glucose	92,99	insulin	56,63	glucose	insulin	MESH:D005947	3630	Chemical	Gene	exposure|compound|START_ENTITY delivery|nmod|exposure delivery|compound|END_ENTITY	Increased action of pulsatile compared to non-pulsatile insulin delivery during a meal-like glucose exposure simulated by computerized infusion in healthy humans .
22409999	0	glucose	28,35	insulin	61,68	glucose	insulin	MESH:D005947	3630	Chemical	Gene	effect|nmod|START_ENTITY control|nsubj|effect control|nmod|resistance resistance|compound|END_ENTITY	The effect of perioperative glucose control on postoperative insulin resistance .
22445514	0	glucose	81,88	insulin	11,18	glucose	insulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY derived|nmod|test derived|csubj|Estimating Estimating|dobj|secretion secretion|compound|END_ENTITY	Estimating insulin secretion in youth using simple indices derived from the oral glucose tolerance test .
22456864	0	glucose	57,64	insulin	145,152	glucose	insulin	MESH:D005947	3630	Chemical	Gene	START_ENTITY|acl|monitoring monitoring|advcl|using using|dobj|regimens regimens|compound|END_ENTITY	Assessment of patient-led or physician-driven continuous glucose monitoring in patients with poorly controlled type 1 diabetes using basal-bolus insulin regimens : a 1-year multicenter study .
2246975	0	glucose	42,49	insulin	11,18	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	production|compound|START_ENTITY Effects|nmod|production Effects|nmod|END_ENTITY	Effects of insulin on glucagon-stimulated glucose production in the conscious dog .
22486156	0	glucose	27,34	insulin	71,78	glucose	insulin	MESH:D005947	3630	Chemical	Gene	using|dobj|START_ENTITY Experiences|acl|using targets|nsubj|Experiences targets|advcl|following following|dobj|regimen regimen|compound|END_ENTITY	Experiences of using blood glucose targets when following an intensive insulin regimen : a qualitative longitudinal investigation involving patients with Type 1 diabetes .
2251213	0	glucose	95,102	insulin	17,24	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY patients|nmod|tolerance test|nmod|patients test|nsubj|levels levels|nmod|END_ENTITY	-LSB- Blood levels of insulin and growth_hormone during exercise test in obese patients with normal glucose tolerance and with diabetes_mellitus after food intake and fasting -RSB- .
22522495	0	glucose	16,23	insulin	119,126	glucose	insulin	MESH:D005947	3630	Chemical	Gene	uptake|compound|START_ENTITY remains|nsubj|uptake elevated|dep|remains elevated|nmod|cessation cessation|nmod|independent independent|nmod|response response|compound|END_ENTITY	Regional muscle glucose uptake remains elevated one week after cessation of resistance training independent of altered insulin sensitivity response in older adults with type 2 diabetes .
2258000	0	glucose	34,41	insulin	14,21	glucose	insulin	MESH:D005947	3630	Chemical	Gene	transporters|compound|START_ENTITY patients|nsubj|transporters regulatable|xcomp|patients regulatable|nsubj|Expression Expression|nmod|END_ENTITY	Expression of insulin regulatable glucose transporters in skeletal muscle from type 2 -LRB- non-insulin-dependent -RRB- diabetic patients .
22617471	0	glucose	14,21	insulin	35,42	glucose	insulin	MESH:D005947	3630	Chemical	Gene	transport|compound|START_ENTITY transport|nmod|END_ENTITY	Regulation of glucose transport by insulin : traffic control of GLUT4 .
22620702	0	glucose	42,49	insulin	99,106	glucose	insulin	MESH:D005947	100060077(Tax:9796)	Chemical	Gene	administration|nmod|START_ENTITY Effect|nmod|administration exercise|nsubj|Effect exercise|nmod|concentration concentration|compound|END_ENTITY	Effect of repeated oral administration of glucose and leucine immediately after exercise on plasma insulin concentration and glycogen synthesis in horses .
2262424	0	glucose	26,33	insulin	63,70	glucose	insulin	MESH:D005947	105613195	Chemical	Gene	responsiveness|compound|START_ENTITY responsiveness|nmod|responsiveness responsiveness|nmod|END_ENTITY	Insulin responsiveness to glucose and tissue responsiveness to insulin over the feeding cycle in sheep .
22729969	0	glucose	49,56	insulin	66,73	glucose	insulin	MESH:D005947	3630	Chemical	Gene	25-hydroxyvitamin_D|nmod|START_ENTITY Associations|nmod|25-hydroxyvitamin_D fasting|nsubj|Associations fasting|dobj|END_ENTITY	Associations of 25-hydroxyvitamin_D with fasting glucose , fasting insulin , dementia and depression in European elderly : the SENECA study .
22730862	0	glucose	25,32	insulin	13,20	glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY END_ENTITY|nmod|control	Timely bolus insulin for glucose control during cardiopulmonary bypass .
22775404	0	glucose	167,174	insulin	122,129	glucose	insulin	MESH:D005947	3630	Chemical	Gene	monitoring|compound|START_ENTITY using|dobj|monitoring daily|dep|using receiving|advmod|daily receiving|dobj|glargine glargine|nmod|detemir detemir|compound|END_ENTITY	A crossover comparison of glycemic variations in Japanese patients with type 1 diabetes receiving insulin glargine versus insulin detemir twice daily using continuous glucose monitoring -LRB- CGM -RRB- : J COLLECTION -LRB- Jikei COmparison of Lantus and LEvemir with Cgm for Thinking Insulin OptimizatioN -RRB- .
22775404	0	glucose	167,174	insulin	98,105	glucose	insulin	MESH:D005947	3630	Chemical	Gene	monitoring|compound|START_ENTITY using|dobj|monitoring daily|dep|using receiving|advmod|daily receiving|dobj|glargine glargine|compound|END_ENTITY	A crossover comparison of glycemic variations in Japanese patients with type 1 diabetes receiving insulin glargine versus insulin detemir twice daily using continuous glucose monitoring -LRB- CGM -RRB- : J COLLECTION -LRB- Jikei COmparison of Lantus and LEvemir with Cgm for Thinking Insulin OptimizatioN -RRB- .
22785565	0	glucose	169,176	insulin	35,42	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	clamp|nsubj|START_ENTITY dogs|ccomp|clamp dogs|nsubj|Characterization Characterization|nmod|resistance resistance|compound|END_ENTITY	Characterization and comparison of insulin resistance induced by Cushing_Syndrome or diestrus against healthy control dogs as determined by euglycemic - hyperinsulinemic glucose clamp profile glucose infusion rate using an artificial pancreas apparatus .
22785565	0	glucose	191,198	insulin	35,42	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	rate|compound|START_ENTITY clamp|dobj|rate dogs|ccomp|clamp dogs|nsubj|Characterization Characterization|nmod|resistance resistance|compound|END_ENTITY	Characterization and comparison of insulin resistance induced by Cushing_Syndrome or diestrus against healthy control dogs as determined by euglycemic - hyperinsulinemic glucose clamp profile glucose infusion rate using an artificial pancreas apparatus .
22827507	0	glucose	85,92	insulin	40,47	glucose	insulin	MESH:D005947	3630	Chemical	Gene	monitoring|compound|START_ENTITY augmented|nmod|monitoring therapy|acl|augmented pump|dobj|therapy pump|nsubj|Ramadan Ramadan|acl|fasting fasting|nmod|patients patients|nmod|END_ENTITY	Ramadan fasting in diabetes patients on insulin pump therapy augmented by continuous glucose monitoring : an observational real-life study .
22862962	0	glucose	23,30	insulin	105,112	glucose	insulin	MESH:D005947	3630	Chemical	Gene	homeostasis|compound|START_ENTITY pathways|nmod|homeostasis pathways|nmod|hepatitis_C_virus hepatitis_C_virus|acl|induced induced|dobj|resistance resistance|compound|END_ENTITY	Molecular pathways for glucose homeostasis , insulin signaling and autophagy in hepatitis_C_virus induced insulin resistance in a cellular model .
22872689	0	glucose	16,23	insulin	37,44	glucose	insulin	MESH:D005947	3630	Chemical	Gene	Effect|nmod|START_ENTITY control|nsubj|Effect control|nmod|END_ENTITY	Effect of tight glucose control with insulin on the thyroid_axis of critically ill children and its relation with outcome .
22907764	0	glucose	35,42	insulin	58,65	glucose	insulin	MESH:D005947	3630	Chemical	Gene	fasting|dobj|START_ENTITY normalization|acl|fasting Effect|nmod|normalization intensified|nsubj|Effect intensified|dobj|therapy therapy|compound|END_ENTITY	Effect of normalization of fasting glucose by intensified insulin therapy and influence of eNOS polymorphisms on the incidence of restenosis after peripheral angioplasty in patients with type 2 diabetes : a randomized , open-label clinical trial .
22964124	0	glucose	11,18	insulin	33,40	glucose	insulin	MESH:D005947	3630	Chemical	Gene	monitoring|compound|START_ENTITY monitoring|nmod|pump pump|compound|END_ENTITY	Continuous glucose monitoring in insulin pump treated children .
23003329	0	glucose	33,40	insulin	169,176	glucose	insulin	MESH:D005947	3630	Chemical	Gene	method|compound|START_ENTITY Evaluation|nmod|method Evaluation|dep|iBolus iBolus|dep|using using|dobj|therapy therapy|compound|END_ENTITY	Evaluation of a novel continuous glucose monitoring-based method for mealtime insulin dosing -- the iBolus -- in subjects with type 1 diabetes using continuous subcutaneous insulin infusion therapy : a randomized controlled trial .
23003329	0	glucose	33,40	insulin	78,85	glucose	insulin	MESH:D005947	3630	Chemical	Gene	method|compound|START_ENTITY method|nmod|dosing dosing|compound|END_ENTITY	Evaluation of a novel continuous glucose monitoring-based method for mealtime insulin dosing -- the iBolus -- in subjects with type 1 diabetes using continuous subcutaneous insulin infusion therapy : a randomized controlled trial .
23011594	0	glucose	89,96	insulin	58,65	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	metabolism|compound|START_ENTITY Interaction|nmod|metabolism Interaction|nmod|END_ENTITY	Interaction between the central and peripheral effects of insulin in controlling hepatic glucose metabolism in the conscious dog .
23035774	0	glucose	38,45	insulin	15,22	glucose	insulin	MESH:D005947	3630	Chemical	Gene	normalization|compound|START_ENTITY adjustment|nmod|normalization adjustment|compound|END_ENTITY	`` Symptom-based insulin adjustment for glucose normalization '' -LRB- SIGN -RRB- algorithm : a pilot study .
23056385	0	glucose	49,56	insulin	93,100	glucose	insulin	MESH:D005947	3630	Chemical	Gene	signalling|compound|START_ENTITY signalling|acl|linked linked|nmod|secretion secretion|compound|END_ENTITY	The mitochondrial Na + / Ca2 + exchanger upregulates glucose dependent Ca2 + signalling linked to insulin secretion .
23063039	0	glucose	42,49	insulin	10,17	glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY feedback|nmod|control feedback|compound|END_ENTITY	Effect of insulin feedback on closed-loop glucose control : a crossover study .
23067236	0	glucose	23,30	insulin	161,168	glucose	insulin	MESH:D005947	3630	Chemical	Gene	levels|compound|START_ENTITY Associations|nmod|levels Associations|parataxis|mediated mediated|nmod|resistance resistance|compound|END_ENTITY	Associations of plasma glucose levels and traits of metabolic_syndrome with carotid intima_media_thickness in nondiabetic elderly subjects : are they mediated by insulin resistance ?
23084884	0	glucose	106,113	insulin	65,72	glucose	insulin	MESH:D005947	280829(Tax:9913)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of increasing doses of 2 preparations of long-acting insulin on short-term plasma profiles of glucose and insulin in lactating dairy cows .
23131894	0	glucose	114,121	insulin	10,17	glucose	insulin	MESH:D005947	3630	Chemical	Gene	levels|compound|START_ENTITY treated|nmod|levels treated|nsubj|secretion secretion|compound|END_ENTITY	Excessive insulin secretion in Japanese schizophrenic patients treated with antipsychotics despite normal fasting glucose levels .
23135788	0	glucose	141,148	insulin	16,23	glucose	insulin	MESH:D005947	105613195	Chemical	Gene	supply|compound|START_ENTITY improve|nmod|supply fail|xcomp|improve fail|nsubj|concentrations concentrations|compound|END_ENTITY	Increased fetal insulin concentrations for one week fail to improve insulin secretion or b-cell mass in fetal sheep with chronically reduced glucose supply .
23135788	0	glucose	141,148	insulin	68,75	glucose	insulin	MESH:D005947	105613195	Chemical	Gene	supply|compound|START_ENTITY improve|nmod|supply improve|dobj|secretion secretion|nmod:npmod|END_ENTITY	Increased fetal insulin concentrations for one week fail to improve insulin secretion or b-cell mass in fetal sheep with chronically reduced glucose supply .
23151437	0	glucose	32,39	insulin	82,89	glucose	insulin	MESH:D005947	3630	Chemical	Gene	uptake|compound|START_ENTITY Measurement|nmod|uptake Measurement|dep|comparison comparison|nmod|test test|compound|END_ENTITY	Measurement of insulin-mediated glucose uptake : direct comparison of the modified insulin suppression test and the euglycemic , _ hyperinsulinemic_clamp .
23223406	0	glucose	174,181	insulin	78,85	glucose	insulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY derived|nmod|test impact|acl|derived impact|dep|using using|advcl|predict predict|dobj|sensitivity sensitivity|compound|END_ENTITY	Limitations in the use of indices using glucose and insulin levels to predict insulin sensitivity : impact of race and gender and superiority of the indices derived from oral glucose tolerance test in African Americans .
23223406	0	glucose	40,47	insulin	78,85	glucose	insulin	MESH:D005947	3630	Chemical	Gene	levels|compound|START_ENTITY using|dobj|levels using|advcl|predict predict|dobj|sensitivity sensitivity|compound|END_ENTITY	Limitations in the use of indices using glucose and insulin levels to predict insulin sensitivity : impact of race and gender and superiority of the indices derived from oral glucose tolerance test in African Americans .
23249601	5	glucose	825,832	insulin	751,758	glucose	insulin	MESH:D005947	3630	Chemical	Gene	rate|compound|START_ENTITY value|acl:relcl|rate value|nsubj|indices indices|compound|END_ENTITY	The insulin resistance indices used were the M value , which is the total body glucose disposal rate , and the M/I value , which is the M value adjusted for the steady state plasma insulin level .
23339473	0	glucose	39,46	insulin	83,90	glucose	insulin	MESH:D005947	3630	Chemical	Gene	fasting|dobj|START_ENTITY /|dep|fasting index|nsubj|/ index|nmod|resistance resistance|compound|END_ENTITY	20 / -LRB- fasting C-peptide fasting plasma glucose -RRB- is a simple and effective index of insulin resistance in patients with type_2_diabetes_mellitus : a preliminary report .
23342086	0	glucose	96,103	insulin	115,122	glucose	insulin	MESH:D005947	3630	Chemical	Gene	START_ENTITY|acl|stimulated stimulated|dobj|secretion secretion|compound|END_ENTITY	The adipocytokine Nampt and its product NMN have no effect on beta-cell survival but potentiate glucose stimulated insulin secretion .
23370528	0	glucose	114,121	insulin	146,153	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY deterioration|nmod|tolerance produces|dobj|deterioration produces|nmod|clearance clearance|compound|END_ENTITY	Systemic inhibition of nitric_oxide synthesis in non-diabetic individuals produces a significant deterioration in glucose tolerance by increasing insulin clearance and inhibiting insulin secretion .
23386016	0	glucose	71,78	insulin	43,50	glucose	insulin	MESH:D005947	3630	Chemical	Gene	protocols|nmod|START_ENTITY protocols|compound|END_ENTITY	Assessment of nursing perceptions of three insulin protocols for blood glucose control in critically_ill patients .
23439172	0	glucose	84,91	insulin	19,26	glucose	insulin	MESH:D005947	3630	Chemical	Gene	measurements|compound|START_ENTITY self-monitoring|nmod|measurements depicted|dobj|self-monitoring depicted|nsubj|Self-adjustment Self-adjustment|nmod|dose dose|compound|END_ENTITY	Self-adjustment of insulin dose using graphically depicted self-monitoring of blood glucose measurements in patients with type_1_diabetes_mellitus .
23511296	0	glucose	46,53	insulin	91,98	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tests|compound|START_ENTITY intraperitoneal|dobj|tests intraperitoneal|nmod|evaluation evaluation|nmod|resistance resistance|compound|END_ENTITY	Evaluation of intragastric vs intraperitoneal glucose tolerance tests in the evaluation of insulin resistance in a rodent model of burn_injury and glucagon-like_polypeptide-1 treatment .
23546809	4	glucose	793,800	insulin	740,747	glucose	insulin	MESH:D005947	3630	Chemical	Gene	curve|compound|START_ENTITY HOMA-IR|appos|curve had|dobj|HOMA-IR had|nsubj|Obese_adolescents Obese_adolescents|nmod|resistance resistance|compound|END_ENTITY	Obese_adolescents with insulin resistance had significantly higher HOMA-IR , glucose response curve -LRB- AUC -RRB- , insulin AUC , PT 1.2 , FPA and fibrinogen and aggregation -LRB- to collagen 1 g/ml , ADP 10 mol/L and AA 0.5 mmol/L -RRB- comparison with obese_adolescents without insulin resistance -LRB- P < 0.05 -RRB- .
23596179	0	glucose	21,28	insulin	59,66	glucose	insulin	MESH:D005947	3630	Chemical	Gene	rate|compound|START_ENTITY Use|nmod|rate Use|nmod|resistance resistance|compound|END_ENTITY	Use of the estimated glucose disposal rate as a measure of insulin resistance in an urban multiethnic population with type 1 diabetes .
23631604	0	glucose	21,28	insulin	67,74	glucose	insulin	MESH:D005947	3630	Chemical	Gene	monitoring|compound|START_ENTITY subcutaneous|nsubj|monitoring subcutaneous|dobj|infusion infusion|compound|END_ENTITY	Real-time continuous glucose monitoring or continuous subcutaneous insulin infusion , what goes first ?
23711193	0	glucose	21,28	insulin	80,87	glucose	insulin	MESH:D005947	3630	Chemical	Gene	management|compound|START_ENTITY Options|nmod|management Options|acl|using using|dobj|END_ENTITY	Options for prandial glucose management in type 2 diabetes patients using basal insulin : addition of a short-acting GLP-1 analogue versus progression to basal-bolus therapy .
23756662	0	glucose	35,42	insulin	73,80	glucose	insulin	MESH:D005947	3630	Chemical	Gene	ratio|compound|START_ENTITY CPR|nmod|ratio Correlation|nmod|CPR Correlation|nmod|secretion secretion|compound|END_ENTITY	Correlation of serum CPR to plasma glucose ratio with various indices of insulin secretion and diseases duration in type 2 diabetes .
23849871	0	glucose	41,48	insulin	19,26	glucose	insulin	MESH:D005947	3630	Chemical	Gene	system|compound|START_ENTITY signaling|dobj|system Effects|acl|signaling Effects|nmod|H2O2 H2O2|nmod|END_ENTITY	Effects of H2O2 on insulin signaling the glucose transport system in mammalian skeletal muscle .
23875163	0	glucose	6,13	insulin	22,29	glucose	insulin	MESH:D005947	3630	Chemical	Gene	levels|compound|START_ENTITY levels|appos|concentrations concentrations|compound|END_ENTITY	Blood glucose levels , insulin concentrations , and insulin resistance in healthy women and women with premenstrual_syndrome : a comparative study .
23876704	0	glucose	14,21	insulin	55,62	glucose	insulin	MESH:D005947	3630	Chemical	Gene	Evaluation|nmod|START_ENTITY variability|nsubj|Evaluation variability|advcl|converting converting|nmod|infusion infusion|compound|END_ENTITY	Evaluation of glucose variability when converting from insulin infusion to basal-bolus regimen in a surgical-trauma intensive care unit .
23931715	0	glucose	84,91	insulin	177,184	glucose	insulin	MESH:D005947	3630	Chemical	Gene	variability|compound|START_ENTITY fatty_acid|nmod|variability fatty_acid|nmod|feeding feeding|acl:relcl|require require|dobj|therapy therapy|compound|END_ENTITY	Effects of low-carbohydrate/high-monounsaturated _ fatty_acid liquid diets on diurnal glucose variability and insulin dose in type 2 diabetes patients on tube feeding who require insulin therapy .
23984046	0	glucose	42,49	insulin	87,94	glucose	insulin	MESH:D005947	3630	Chemical	Gene	phenylalanine|nmod|START_ENTITY Ingestion|nmod|phenylalanine produces|nsubj|Ingestion produces|nmod|END_ENTITY	Ingestion of leucine + phenylalanine with glucose produces an additive effect on serum insulin but less than additive effect on plasma glucose .
24089542	0	glucose	78,85	insulin	42,49	glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY improves|dobj|control improves|nsubj|injection injection|nmod|END_ENTITY	Needle-free jet injection of rapid-acting insulin improves early postprandial glucose control in patients with diabetes .
24124961	0	glucose	100,107	insulin	121,128	glucose	insulin	MESH:D005947	3630	Chemical	Gene	profile|compound|START_ENTITY profile|nmod|glargine glargine|compound|END_ENTITY	A novel insulin combination of insulin degludec and insulin aspart achieves a more stable overnight glucose profile than insulin glargine : results from continuous glucose monitoring in a proof-of-concept trial .
24124961	0	glucose	100,107	insulin	31,38	glucose	insulin	MESH:D005947	3630	Chemical	Gene	profile|compound|START_ENTITY achieves|dobj|profile achieves|nsubj|combination combination|nmod|degludec degludec|compound|END_ENTITY	A novel insulin combination of insulin degludec and insulin aspart achieves a more stable overnight glucose profile than insulin glargine : results from continuous glucose monitoring in a proof-of-concept trial .
24124961	0	glucose	100,107	insulin	8,15	glucose	insulin	MESH:D005947	3630	Chemical	Gene	profile|compound|START_ENTITY achieves|dobj|profile achieves|nsubj|combination combination|compound|END_ENTITY	A novel insulin combination of insulin degludec and insulin aspart achieves a more stable overnight glucose profile than insulin glargine : results from continuous glucose monitoring in a proof-of-concept trial .
24124961	0	glucose	163,170	insulin	121,128	glucose	insulin	MESH:D005947	3630	Chemical	Gene	monitoring|compound|START_ENTITY results|nmod|monitoring profile|dep|results profile|nmod|glargine glargine|compound|END_ENTITY	A novel insulin combination of insulin degludec and insulin aspart achieves a more stable overnight glucose profile than insulin glargine : results from continuous glucose monitoring in a proof-of-concept trial .
24124961	0	glucose	163,170	insulin	31,38	glucose	insulin	MESH:D005947	3630	Chemical	Gene	monitoring|compound|START_ENTITY results|nmod|monitoring profile|dep|results achieves|dobj|profile achieves|nsubj|combination combination|nmod|degludec degludec|compound|END_ENTITY	A novel insulin combination of insulin degludec and insulin aspart achieves a more stable overnight glucose profile than insulin glargine : results from continuous glucose monitoring in a proof-of-concept trial .
24124961	0	glucose	163,170	insulin	8,15	glucose	insulin	MESH:D005947	3630	Chemical	Gene	monitoring|compound|START_ENTITY results|nmod|monitoring profile|dep|results achieves|dobj|profile achieves|nsubj|combination combination|compound|END_ENTITY	A novel insulin combination of insulin degludec and insulin aspart achieves a more stable overnight glucose profile than insulin glargine : results from continuous glucose monitoring in a proof-of-concept trial .
2422103	0	glucose	23,30	insulin	47,54	glucose	insulin	MESH:D005947	3630	Chemical	Gene	profiles|compound|START_ENTITY profiles|nmod|aprotinin aprotinin|compound|END_ENTITY	Twenty-four hour blood glucose profiles during insulin and insulin plus aprotinin subcutaneous administration in type_I_diabetes .
2422103	2	glucose	454,461	insulin	437,444	glucose	insulin	MESH:D005947	3630	Chemical	Gene	levels|compound|START_ENTITY influence|nmod|levels influence|dobj|effect effect|nmod|END_ENTITY	Aprotinin -- a proteinase inhibitor agent -- administered together with insulin -LRB- 10.000 KIU for every 10 U.I. insulin -RRB- did not influence the effect of insulin on blood glucose levels .
24229692	0	glucose	85,92	insulin	23,30	glucose	insulin	MESH:D005947	3630	Chemical	Gene	index|compound|START_ENTITY called|dobj|index called|nsubj|Efficacy Efficacy|nmod|treatment treatment|compound|END_ENTITY	Efficacy and safety of insulin treatment in type 2 diabetes using a new index called glucose safety control index .
24353179	0	glucose	106,113	insulin	61,68	glucose	insulin	MESH:D005947	3630	Chemical	Gene	production|compound|START_ENTITY protein|nmod|production protein|nmod|analog analog|compound|END_ENTITY	Proinsulin-transferrin fusion protein as a novel long-acting insulin analog for the inhibition of hepatic glucose production .
24386218	0	glucose	45,52	insulin	119,126	glucose	insulin	MESH:D005947	3630	Chemical	Gene	levels|compound|START_ENTITY lowers|dobj|levels lowers|nmod|levels levels|nmod|END_ENTITY	A tripeptide Diapin effectively lowers blood glucose levels in male type_2_diabetes mice by increasing blood levels of insulin and GLP-1 .
24427529	0	glucose	64,71	insulin	24,31	glucose	insulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY secretion|nmod|test secretion|nsubj|modelling modelling|nmod|END_ENTITY	Multiscale modelling of insulin secretion during an intravenous glucose tolerance test .
24446385	0	glucose	20,27	insulin	113,120	glucose	insulin	MESH:D005947	3630	Chemical	Gene	Modeling|nmod|START_ENTITY treated|nsubj|Modeling treated|nmod|aspart aspart|compound|END_ENTITY	Modeling of 24-hour glucose and insulin profiles in patients with type_2_diabetes_mellitus treated with biphasic insulin aspart .
24535122	0	glucose	12,19	insulin	64,71	glucose	insulin	MESH:D005947	3630	Chemical	Gene	exposure|compound|START_ENTITY biases|nsubj|exposure biases|dobj|distribution distribution|nmod|granules granules|compound|END_ENTITY	Subcellular glucose exposure biases the spatial distribution of insulin granules in single pancreatic beta cells .
24563017	0	glucose	14,21	insulin	145,152	glucose	insulin	MESH:D005947	3630	Chemical	Gene	Comparison|nmod|START_ENTITY switched|nsubj|Comparison switched|nmod|END_ENTITY	Comparison of glucose variability assessed by a continuous glucose-monitoring system in patients with type_2_diabetes_mellitus switched from NPH insulin to insulin glargine : the COBIN2 study .
24563017	0	glucose	14,21	insulin	156,163	glucose	insulin	MESH:D005947	3630	Chemical	Gene	Comparison|nmod|START_ENTITY switched|nsubj|Comparison switched|nmod|glargine glargine|compound|END_ENTITY	Comparison of glucose variability assessed by a continuous glucose-monitoring system in patients with type_2_diabetes_mellitus switched from NPH insulin to insulin glargine : the COBIN2 study .
24583424	0	glucose	82,89	insulin	25,32	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY stages|nmod|tolerance contribution|nmod|stages contribution|nmod|secretion secretion|compound|END_ENTITY	Relative contribution of insulin secretion and sensitivity at different stages of glucose tolerance : non-obese versus obese Japanese subjects .
24589844	0	glucose	33,40	insulin	80,87	glucose	insulin	MESH:D005947	3630	Chemical	Gene	balance|compound|START_ENTITY control|nmod|balance control|nmod|presence presence|nmod|END_ENTITY	Hypothalamic-mediated control of glucose balance in the presence and absence of insulin .
24618283	0	glucose	34,41	insulin	74,81	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY role|nmod|metabolism role|nmod|regulation regulation|nmod|secretion secretion|compound|END_ENTITY	Potential role of skeletal muscle glucose metabolism on the regulation of insulin secretion .
24651807	8	glucose	1021,1028	insulin	1094,1101	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tracer|compound|START_ENTITY Adding|dobj|tracer enhances|csubj|Adding enhances|dobj|assessment assessment|nmod|action action|compound|END_ENTITY	Adding a glucose tracer to the oral dose significantly enhances the assessment of insulin action by segregating insulin sensitivity into its glucose_disposal_and_hepatic_components .
24652432	0	glucose	61,68	insulin	18,25	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY subjects|nmod|tolerance Identification|nmod|subjects Identification|nmod|resistance resistance|compound|END_ENTITY	Identification of insulin resistance in subjects with normal glucose tolerance .
24675078	0	glucose	10,17	insulin	141,148	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY underlies|nsubj|metabolism underlies|dobj|potentiation potentiation|nmod|secretion secretion|compound|END_ENTITY	Increased glucose metabolism and glycerolipid formation by fatty_acids and GPR40 receptor signaling underlies the fatty_acid potentiation of insulin secretion .
24687695	0	glucose	43,50	insulin	68,75	glucose	insulin	MESH:D005947	3630	Chemical	Gene	measurement|compound|START_ENTITY combining|dobj|measurement combining|nmod|infusion infusion|compound|END_ENTITY	The single-port concept : combining optical glucose measurement with insulin infusion .
24705606	0	glucose	26,33	insulin	74,81	glucose	insulin	MESH:D005947	3630	Chemical	Gene	homeostasis|compound|START_ENTITY enhances|dobj|homeostasis enhances|nmod|mice mice|nmod|potentiation potentiation|nmod|secretion secretion|compound|END_ENTITY	Doc2b enrichment enhances glucose homeostasis in mice via potentiation of insulin secretion and peripheral insulin sensitivity .
24711220	0	glucose	17,24	insulin	55,62	glucose	insulin	MESH:D005947	3630	Chemical	Gene	associated|nsubj|START_ENTITY associated|nmod|defects defects|nmod|secretion secretion|compound|END_ENTITY	High-normal 2 h glucose is associated with defects of insulin secretion and predispose to diabetes in Chinese adults .
24740569	0	glucose	14,21	insulin	25,32	glucose	insulin	MESH:D005947	3630	Chemical	Gene	couples|dobj|START_ENTITY couples|nmod|secretion secretion|compound|END_ENTITY	ADCY5 couples glucose to insulin secretion in human islets .
24837539	1	glucose	253,260	insulin	214,221	glucose	insulin	MESH:D005947	3630	Chemical	Gene	concentration|compound|START_ENTITY associated|nmod|concentration associated|nsubjpass|antibodies antibodies|acl|altering altering|dobj|pharmacokinetics pharmacokinetics|acl|circulating circulating|dobj|END_ENTITY	BACKGROUND : In patients with type 1 diabetes , insulin antibodies -LRB- IA -RRB- , altering the pharmacokinetics of circulating insulin , might be associated with high glucose concentration , prolonged hypoglycemia , and higher insulin requirement .
24842248	0	glucose	129,136	insulin	27,34	glucose	insulin	MESH:D005947	3630	Chemical	Gene	homeostasis|compound|START_ENTITY reproducibility|nmod|homeostasis parameters|dep|reproducibility parameters|nmod|response response|compound|END_ENTITY	Emerging parameters of the insulin and glucose response on the oral glucose tolerance test : reproducibility and implications for glucose homeostasis in individuals with and without diabetes .
24842248	0	glucose	68,75	insulin	27,34	glucose	insulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY response|nmod|test response|compound|END_ENTITY	Emerging parameters of the insulin and glucose response on the oral glucose tolerance test : reproducibility and implications for glucose homeostasis in individuals with and without diabetes .
24843431	0	glucose	102,109	insulin	17,24	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY Japanese|nmod|tolerance predict|nmod|Japanese predict|nsubj|tests tests|nmod|secretion secretion|compound|END_ENTITY	Fasting tests of insulin secretion and sensitivity predict future prediabetes in Japanese with normal glucose tolerance .
24843445	0	glucose	92,99	insulin	11,18	glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY stability|nmod|control contributes|nmod|stability contributes|nsubj|secretion secretion|compound|END_ENTITY	Endogenous insulin secretion even at a very low level contributes to the stability of blood glucose control in fulminant type 1 diabetes .
24843473	0	glucose	70,77	insulin	20,27	glucose	insulin	MESH:D005947	3630	Chemical	Gene	using|dobj|START_ENTITY factors|dep|using composed|nmod|factors composed|nsubj|index index|nmod|sensitivity sensitivity|compound|END_ENTITY	Surrogate index for insulin sensitivity composed of factors not using glucose and insulin in Japanese patients with diabetes .
24886287	0	glucose	151,158	insulin	24,31	glucose	insulin	MESH:D005947	3630	Chemical	Gene	monitoring|compound|START_ENTITY setting|nmod|monitoring care|acl|setting type_2_diabetes|nmod|care patients|nmod|type_2_diabetes trial|nmod|patients trial|nmod|initiation initiation|compound|END_ENTITY	An exploratory trial of insulin initiation and titration among patients with type_2_diabetes in the primary care setting with retrospective continuous glucose monitoring as an adjunct : INITIATION study protocol .
24886864	0	glucose	15,22	insulin	125,132	glucose	insulin	MESH:D005947	3630	Chemical	Gene	variation|compound|START_ENTITY Coefficient|nmod|variation associated|nsubjpass|Coefficient associated|xcomp|receiving receiving|dobj|END_ENTITY	Coefficient of glucose variation is independently associated with mortality in critically ill patients receiving intravenous insulin .
24891878	0	glucose	6,13	insulin	85,92	glucose	insulin	MESH:D005947	3630	Chemical	Gene	based|nsubj|START_ENTITY based|dobj|composition composition|nmod|model model|compound|END_ENTITY	Blood glucose lowering activity of aloe based composition , UP780 , in alloxan induced insulin dependent mouse diabetes model .
24929430	0	glucose	9,16	insulin	160,167	glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY added|nsubj|control added|nmod|injections injections|nmod|END_ENTITY	Improved glucose control with weight_loss , lower insulin doses , and no increased hypoglycemia with empagliflozin added to titrated multiple daily injections of insulin in obese inadequately controlled type 2 diabetes .
24947349	0	glucose	11,18	insulin	97,104	glucose	insulin	MESH:D005947	3630	Chemical	Gene	Changes|nmod|START_ENTITY metabolism|nsubj|Changes metabolism|nmod|administration administration|nmod|analog analog|compound|END_ENTITY	Changes in glucose and fat metabolism in response to the administration of a hepato-preferential insulin analog .
249676	0	glucose	6,13	insulin	15,22	glucose	insulin	MESH:D005947	3630	Chemical	Gene	START_ENTITY|appos|levels levels|compound|END_ENTITY	Blood glucose , insulin , cholesterol and triglyceride levels in women treated for six months with the weekly oral contraceptive R2323 .
25062651	0	glucose	90,97	insulin	36,43	glucose	insulin	MESH:D005947	3630	Chemical	Gene	level|compound|START_ENTITY regimen|nmod|level glargine|dobj|regimen glargine|nsubj|Efficacy Efficacy|nmod|END_ENTITY	Efficacy and safety of weight-based insulin glargine dose titration regimen compared with glucose level - and current dose-based regimens in hospitalized patients with type 2 diabetes : a randomized , controlled study .
25080048	1	glucose	125,132	insulin	282,289	glucose	insulin	MESH:D005947	3630	Chemical	Gene	system|compound|START_ENTITY sensors|nmod|system studied|nsubjpass|sensors applied|advcl|studied applied|nmod|potential potential|nmod|sensors sensors|compound|END_ENTITY	UNASSIGNED : While implantable sensors such as the continuous glucose monitoring system have been widely studied , both experimentally and mathematically , relatively little attention has been applied to the potential of insulin sensors .
25123125	15	glucose	2841,2848	insulin	2823,2830	glucose	insulin	MESH:D005947	3630	Chemical	Gene	transport|compound|START_ENTITY action|nmod|transport action|compound|END_ENTITY	In type 2 diabetes an altered intracellular distribution of SNAP23 and impaired activation of RAC1 also seem to play a role for reduced insulin action on glucose transport .
25164450	0	glucose	46,53	insulin	80,87	glucose	insulin	MESH:D005947	3630	Chemical	Gene	administration|nmod|START_ENTITY attenuates|nsubj|administration attenuates|dobj|resistance resistance|compound|END_ENTITY	Intra-operative administration of low-dose IV glucose attenuates post-operative insulin resistance .
25176602	2	glucose	380,387	insulin	461,468	glucose	insulin	MESH:D005947	3630	Chemical	Gene	flux|compound|START_ENTITY changes|nmod|flux mediated|nmod|changes mediated|nmod|tissues tissues|acl:relcl|drive drive|dobj|secretion secretion|compound|END_ENTITY	Such sensing mechanism could be mediated by changes in glucose flux -LRB- uptake , oxidation or storage -RRB- in peripheral tissues that may drive insulin secretion .
25250633	0	glucose	51,58	insulin	73,80	glucose	insulin	MESH:D005947	3630	Chemical	Gene	production|compound|START_ENTITY suppression|nmod|production triglycerides|nmod|suppression triglycerides|nmod|END_ENTITY	Influence of liver triglycerides on suppression of glucose production by insulin in men .
25254046	0	glucose	87,94	insulin	33,40	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY resistance|nmod|tolerance resistance|compound|END_ENTITY	The study of serum vitamin_d and insulin resistance in chinese populations with normal glucose tolerance .
25267549	0	glucose	107,114	insulin	64,71	glucose	insulin	MESH:D005947	3630	Chemical	Gene	statuses|compound|START_ENTITY secretions|nmod|statuses secretions|nsubj|Correlation Correlation|nmod|effect effect|nmod|END_ENTITY	Correlation of the incretin effect with first - and second-phase insulin secretions in Koreans with various glucose tolerance statuses .
25288674	0	glucose	41,48	insulin	11,18	glucose	insulin	MESH:D005947	3630	Chemical	Gene	production|compound|START_ENTITY endogenous|dobj|production endogenous|nsubj|suppresses suppresses|compound|END_ENTITY	Intranasal insulin suppresses endogenous glucose production in humans compared to placebo , in the presence of similar venous insulin concentration .
25288674	0	glucose	41,48	insulin	125,132	glucose	insulin	MESH:D005947	3630	Chemical	Gene	production|compound|START_ENTITY endogenous|dobj|production endogenous|nmod|presence presence|nmod|concentration concentration|compound|END_ENTITY	Intranasal insulin suppresses endogenous glucose production in humans compared to placebo , in the presence of similar venous insulin concentration .
25297572	0	glucose	59,66	insulin	31,38	glucose	insulin	MESH:D005947	3630	Chemical	Gene	concentrations|compound|START_ENTITY secretion|nmod|concentrations secretion|nsubj|effect effect|nmod|glibenclamide glibenclamide|nmod|END_ENTITY	The effect of glibenclamide on insulin secretion at normal glucose concentrations .
25313899	0	glucose	43,50	insulin	63,70	glucose	insulin	MESH:D005947	3630	Chemical	Gene	uptake|compound|START_ENTITY uncouples|dobj|uptake uncouples|nmod|END_ENTITY	Browning of white adipose tissue uncouples glucose uptake from insulin signaling .
25322843	0	glucose	108,115	insulin	89,96	glucose	insulin	MESH:D005947	3630	Chemical	Gene	conditions|compound|START_ENTITY required|nmod|conditions required|nmod|effect effect|nmod|END_ENTITY	daf-16 / FOXO and glod-4 / glyoxalase-1 are required for the life-prolonging effect of human insulin under high glucose conditions in Caenorhabditis_elegans .
25328007	0	glucose	54,61	insulin	19,26	glucose	insulin	MESH:D005947	3630	Chemical	Gene	technique|compound|START_ENTITY assessed|nmod|technique assessed|nsubj|prevalence prevalence|nmod|resistance resistance|compound|END_ENTITY	High prevalence of insulin resistance assessed by the glucose clamp technique in hormonal and non-hormonal contraceptive users .
25328079	0	glucose	75,82	insulin	116,123	glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY control|nmod|effects effects|nmod|secretion secretion|compound|END_ENTITY	Addition of sitagliptin or metformin to insulin monotherapy improves blood glucose control via different effects on insulin and glucagon secretion in hyperglycemic Japanese patients with type 2 diabetes .
25328079	0	glucose	75,82	insulin	40,47	glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY improves|dobj|control improves|nsubj|Addition Addition|nmod|sitagliptin sitagliptin|nmod|END_ENTITY	Addition of sitagliptin or metformin to insulin monotherapy improves blood glucose control via different effects on insulin and glucagon secretion in hyperglycemic Japanese patients with type 2 diabetes .
25355081	0	glucose	79,86	insulin	49,56	glucose	insulin	MESH:D005947	3630	Chemical	Gene	load|compound|START_ENTITY levels|nmod|load levels|compound|END_ENTITY	An inverse U-shaped association of late and peak insulin levels during an oral glucose load with glucose_intolerance in a Japanese population : a cross-sectional study .
25360162	0	glucose	60,67	insulin	21,28	glucose	insulin	MESH:D005947	3630	Chemical	Gene	technique|compound|START_ENTITY using|dobj|technique evaluated|xcomp|using resistance|acl|evaluated resistance|compound|END_ENTITY	Bezafibrate improves insulin resistance evaluated using the glucose clamp technique in patients with type_2_diabetes_mellitus : a small-scale clinical study .
25373904	0	glucose	39,46	insulin	93,100	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY linking|dobj|metabolism linking|advcl|incretin/cAMP incretin/cAMP|advcl|amplify amplify|dobj|secretion secretion|compound|END_ENTITY	Glutamate acts as a key signal linking glucose metabolism to incretin/cAMP action to amplify insulin secretion .
25489054	0	glucose	34,41	insulin	113,120	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY genes|nmod|metabolism Identification|nmod|genes based|nsubj|Identification based|nmod|secretion secretion|compound|END_ENTITY	Identification of novel genes for glucose metabolism based upon expression pattern in human islets and effect on insulin secretion and glycemia .
25517049	0	glucose	50,57	insulin	21,28	glucose	insulin	MESH:D005947	3630	Chemical	Gene	load|compound|START_ENTITY levels|nmod|load levels|compound|END_ENTITY	-LSB- Evaluation of serum insulin levels after an oral glucose load for the diagnosis of insulin resistance -RSB- .
25517049	0	glucose	50,57	insulin	84,91	glucose	insulin	MESH:D005947	3630	Chemical	Gene	load|compound|START_ENTITY load|nmod|diagnosis diagnosis|nmod|resistance resistance|compound|END_ENTITY	-LSB- Evaluation of serum insulin levels after an oral glucose load for the diagnosis of insulin resistance -RSB- .
25586464	0	glucose	45,52	insulin	115,122	glucose	insulin	MESH:D005947	3630	Chemical	Gene	levels|compound|START_ENTITY levels|nmod|status status|nmod|weeks weeks|nmod|treatment treatment|nmod|END_ENTITY	Comparison of trajectories of self-monitored glucose levels by hypoglycemia status over 52 weeks of treatment with insulin glargine or exenatide once weekly .
25694300	1	glucose	184,191	insulin	256,263	glucose	insulin	MESH:D005947	3630	Chemical	Gene	system|compound|START_ENTITY system|appos|effect effect|nmod|variability variability|nmod|glargine glargine|compound|END_ENTITY	AIM : To compare , using a continuous glucose monitoring -LRB- CGM -RRB- system , the effect on glycaemic variability of insulin glargine , detemir and lispro protamine .
25884071	0	glucose	156,163	insulin	68,75	glucose	insulin	MESH:D005947	3630	Chemical	Gene	-RSB-|compound|START_ENTITY testing|nmod|-RSB- plasma|advcl|testing plasma|nsubj|fatty_acids fatty_acids|compound|END_ENTITY	-LSB- The content of individual fatty_acids and numbers of double bonds , insulin , C-peptide and unesterified fatty_acids in blood plasma in testing tolerance to glucose -RSB- .
25904987	0	glucose	103,110	insulin	27,34	glucose	insulin	MESH:D005947	3630	Chemical	Gene	self-monitoring|nmod|START_ENTITY associated|nmod|self-monitoring self-adjustment|acl|associated self-adjustment|compound|END_ENTITY	An educational program for insulin self-adjustment associated with structured self-monitoring of blood glucose significantly improves glycemic control in patients with type_2_diabetes_mellitus after 12 weeks : a randomized , controlled pilot study .
25963408	0	glucose	61,68	insulin	79,86	glucose	insulin	MESH:D005947	3630	Chemical	Gene	output|compound|START_ENTITY suppression|nmod|output dispensable|nmod|suppression dispensable|nmod|END_ENTITY	Hepatic insulin signalling is dispensable for suppression of glucose output by insulin in vivo .
25963408	0	glucose	61,68	insulin	8,15	glucose	insulin	MESH:D005947	3630	Chemical	Gene	output|compound|START_ENTITY suppression|nmod|output dispensable|nmod|suppression dispensable|nsubj|signalling signalling|compound|END_ENTITY	Hepatic insulin signalling is dispensable for suppression of glucose output by insulin in vivo .
25973389	0	glucose	92,99	insulin	111,118	glucose	insulin	MESH:D005947	3630	Chemical	Gene	START_ENTITY|acl|stimulated stimulated|dobj|secretion secretion|compound|END_ENTITY	Munc18c mediates exocytosis of pre-docked and newcomer insulin granules underlying biphasic glucose stimulated insulin secretion in human pancreatic beta-cells .
25973389	0	glucose	92,99	insulin	55,62	glucose	insulin	MESH:D005947	3630	Chemical	Gene	granules|dobj|START_ENTITY granules|nsubj|exocytosis exocytosis|nmod|END_ENTITY	Munc18c mediates exocytosis of pre-docked and newcomer insulin granules underlying biphasic glucose stimulated insulin secretion in human pancreatic beta-cells .
25974030	0	glucose	9,16	insulin	92,99	glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY risk|nsubj|control risk|advcl|added added|xcomp|basal basal|dobj|END_ENTITY	Improved glucose control with reduced hypoglycaemic risk when linagliptin is added to basal insulin in elderly patients with type 2 diabetes .
25976046	0	glucose	25,32	insulin	46,53	glucose	insulin	MESH:D005947	3630	Chemical	Gene	Effects|nmod|START_ENTITY control|nsubj|Effects control|nmod|therapy therapy|compound|END_ENTITY	-LSB- Effects of target blood glucose control with insulin therapy on systolic and diastolic cardiac function in septic patients -RSB- .
26021685	0	glucose	40,47	insulin	61,68	glucose	insulin	MESH:D005947	3630	Chemical	Gene	effectiveness|nmod|START_ENTITY END_ENTITY|nsubj|effectiveness	The effectiveness and impact of 10 gram glucose and 10 units insulin in treating hyperkalemia during living donor liver transplantation .
26021685	0	glucose	40,47	insulin	61,68	glucose	insulin	MESH:D005947	3630	Chemical	Gene	effectiveness|nmod|START_ENTITY END_ENTITY|nsubj|effectiveness	The effectiveness and impact of 10 gram glucose and 10 units insulin in treating hyperkalemia during living donor liver transplantation .
26041556	0	glucose	160,167	insulin	112,119	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY individuals|nmod|tolerance secretion|nmod|individuals secretion|compound|END_ENTITY	Relationship between serum secreted_frizzled-related_protein_4 levels and the first-phase of glucose-stimulated insulin secretion in individuals with different glucose tolerance .
26120328	0	glucose	46,53	insulin	11,18	glucose	insulin	MESH:D005947	3630	Chemical	Gene	START_ENTITY|nsubj|Impacts Impacts|nmod|protocol protocol|compound|END_ENTITY	Impacts of insulin infusion protocol on blood glucose level and outcomes in acute_coronary_syndrome patients with diabetes_mellitus .
26232910	0	glucose	86,93	insulin	98,105	glucose	insulin	MESH:D005947	3630	Chemical	Gene	START_ENTITY|nmod|glargine glargine|compound|END_ENTITY	Insulin degludec results in lower rates of nocturnal_hypoglycaemia and fasting plasma glucose vs. insulin glargine : A meta-analysis of seven clinical trials .
26279127	0	glucose	14,21	insulin	130,137	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY Parameters|nmod|metabolism Parameters|dep|Evidence Evidence|nmod|resistance resistance|compound|END_ENTITY	Parameters of glucose and lipid metabolism at the fasted state in drug-na ve first-episode patients with psychosis : Evidence for insulin resistance .
26279127	0	glucose	14,21	insulin	130,137	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY Parameters|nmod|metabolism Parameters|dep|Evidence Evidence|nmod|resistance resistance|compound|END_ENTITY	Parameters of glucose and lipid metabolism at the fasted state in drug-na ve first-episode patients with psychosis : Evidence for insulin resistance .
26288661	0	glucose	102,109	insulin	127,134	glucose	insulin	MESH:D005947	3630	Chemical	Gene	production|compound|START_ENTITY production|nmod|state state|compound|END_ENTITY	Regulation of hepatic TRB3/Akt interaction induced by physical exercise and its effect on the hepatic glucose production in an insulin resistance state .
26343364	0	glucose	69,76	insulin	31,38	glucose	insulin	MESH:D005947	3630	Chemical	Gene	concentration|nmod|START_ENTITY concentration|compound|END_ENTITY	Real-time estimation of plasma insulin concentration from continuous glucose monitor measurements .
26362689	0	glucose	21,28	insulin	101,108	glucose	insulin	MESH:D005947	3630	Chemical	Gene	homeostasis|compound|START_ENTITY aspects|nmod|homeostasis aspects|dep|focus focus|nmod|mechanisms mechanisms|nmod|resistance resistance|compound|END_ENTITY	Molecular aspects of glucose homeostasis in skeletal muscle - A focus on the molecular mechanisms of insulin resistance .
26435033	0	glucose	146,153	insulin	10,17	glucose	insulin	MESH:D005947	3630	Chemical	Gene	data|compound|START_ENTITY analysis|nmod|data Impact|dep|analysis Impact|nmod|initiation initiation|compound|END_ENTITY	Impact of insulin initiation on glycaemic variability and glucose profiles in a primary healthcare Type 2 diabetes cohort : analysis of continuous glucose monitoring data from the INITIATION study .
2644250	1	glucose	122,129	insulin	164,171	glucose	insulin	MESH:D005947	3630	Chemical	Gene	system|compound|START_ENTITY desensitize|dobj|system desensitize|advcl|altering altering|dobj|stimulation stimulation|compound|END_ENTITY	Ability of glucose to selectively desensitize the glucose transport system without altering insulin stimulation of protein synthesis .
2644250	1	glucose	83,90	insulin	164,171	glucose	insulin	MESH:D005947	3630	Chemical	Gene	Ability|nmod|START_ENTITY Ability|acl|desensitize desensitize|advcl|altering altering|dobj|stimulation stimulation|compound|END_ENTITY	Ability of glucose to selectively desensitize the glucose transport system without altering insulin stimulation of protein synthesis .
2645308	0	glucose	116,123	insulin	21,28	glucose	insulin	MESH:D005947	3630	Chemical	Gene	studies|amod|START_ENTITY tests|nmod|studies comparison|nmod|tests Estimates|dep|comparison Estimates|nmod|action action|compound|END_ENTITY	Estimates of in vivo insulin action in man : comparison of insulin tolerance tests with euglycemic and hyperglycemic glucose clamp studies .
2645308	0	glucose	116,123	insulin	58,65	glucose	insulin	MESH:D005947	3630	Chemical	Gene	studies|amod|START_ENTITY tests|nmod|studies tests|compound|END_ENTITY	Estimates of in vivo insulin action in man : comparison of insulin tolerance tests with euglycemic and hyperglycemic glucose clamp studies .
26474657	0	glucose	181,188	insulin	56,63	glucose	insulin	MESH:D005947	3630	Chemical	Gene	monitoring|compound|START_ENTITY using|dobj|monitoring induced|xcomp|using trial|acl|induced trial|nmod|efficacy efficacy|nmod|glargine glargine|compound|END_ENTITY	Randomized clinical trial of the efficacy and safety of insulin glargine vs. NPH insulin as basal insulin for the treatment of glucocorticoid induced hyperglycemia using continuous glucose monitoring in hospitalized patients with type 2 diabetes and respiratory_disease .
26474657	0	glucose	181,188	insulin	81,88	glucose	insulin	MESH:D005947	3630	Chemical	Gene	monitoring|compound|START_ENTITY using|dobj|monitoring induced|xcomp|using trial|acl|induced trial|nmod|END_ENTITY	Randomized clinical trial of the efficacy and safety of insulin glargine vs. NPH insulin as basal insulin for the treatment of glucocorticoid induced hyperglycemia using continuous glucose monitoring in hospitalized patients with type 2 diabetes and respiratory_disease .
26474657	0	glucose	181,188	insulin	98,105	glucose	insulin	MESH:D005947	3630	Chemical	Gene	monitoring|compound|START_ENTITY using|dobj|monitoring induced|xcomp|using trial|acl|induced trial|nmod|END_ENTITY	Randomized clinical trial of the efficacy and safety of insulin glargine vs. NPH insulin as basal insulin for the treatment of glucocorticoid induced hyperglycemia using continuous glucose monitoring in hospitalized patients with type 2 diabetes and respiratory_disease .
2651092	0	glucose	28,35	insulin	109,116	glucose	insulin	MESH:D005947	3630	Chemical	Gene	system|compound|START_ENTITY system|dep|mechanisms mechanisms|nmod|resistance resistance|compound|END_ENTITY	Dexamethasone regulates the glucose transport system in primary cultured adipocytes : different mechanisms of insulin resistance after acute and chronic exposure .
2654305	0	glucose	55,62	insulin	21,28	glucose	insulin	MESH:D005947	3630	Chemical	Gene	concentration|compound|START_ENTITY lower|dobj|concentration eyes|xcomp|lower eyes|nsubj|delivery delivery|nmod|END_ENTITY	Systemic delivery of insulin through eyes to lower the glucose concentration .
2655411	0	glucose	77,84	insulin	85,92	glucose	insulin	MESH:D005947	3630	Chemical	Gene	homeostasis|compound|START_ENTITY homeostasis|compound|END_ENTITY	Relative contribution of obesity and body fat distribution to alterations in glucose insulin homeostasis : predictive values of selected indices in premenopausal women .
2657326	0	glucose	67,74	insulin	24,31	glucose	insulin	MESH:D005947	3630	Chemical	Gene	disposition|compound|START_ENTITY effects|nmod|disposition effects|nmod|END_ENTITY	Differential effects of insulin and hyperglycemia on intracellular glucose disposition in humans .
26598517	0	glucose	52,59	insulin	98,105	glucose	insulin	MESH:D005947	3630	Chemical	Gene	sensor|nsubj|START_ENTITY sensor|xcomp|regulate regulate|dobj|gene gene|compound|END_ENTITY	O-linked b-N-acetylglucosamine -LRB- O-GlcNAc -RRB- acts as a glucose sensor to epigenetically regulate the insulin gene in pancreatic beta cells .
26656958	0	glucose	182,189	insulin	36,43	glucose	insulin	MESH:D005947	3630	Chemical	Gene	monitoring|compound|START_ENTITY using|dobj|monitoring using|nsubj|Comparison Comparison|nmod|regimen regimen|compound|END_ENTITY	Comparison between a multiple daily insulin injection regimen -LRB- basal once-daily glargine plus mealtime lispro -RRB- and continuous subcutaneous insulin infusion -LRB- lispro -RRB- using continuous glucose monitoring in metabolically optimized type 1 diabetes patients : A randomized open-labelled parallel study .
2669517	0	glucose	59,66	insulin	30,37	glucose	insulin	MESH:D005947	3630	Chemical	Gene	production|compound|START_ENTITY secretion|nmod|production secretion|nsubj|Effect Effect|nmod|loss loss|nmod|END_ENTITY	Effect of loss of first-phase insulin secretion on hepatic glucose production and tissue glucose disposal in humans .
2674187	0	glucose	54,61	insulin	123,130	glucose	insulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY secretion|nmod|test secretion|dep|application application|nmod|model model|nmod|kinetics kinetics|compound|END_ENTITY	Prehepatic beta-cell secretion during the intravenous glucose tolerance test in humans : application of a combined model of insulin and C-peptide kinetics .
26772807	0	glucose	99,106	insulin	20,27	glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY type_2_diabetes|nmod|control therapy|nmod|type_2_diabetes END_ENTITY|nmod|therapy	Effects of analogue insulin in multiple daily injection therapy of type_2_diabetes on postprandial glucose control and cardiac function compared to human insulin : a randomized controlled long-term study .
26774018	0	glucose	89,96	insulin	44,51	glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY regulation|nmod|control aspects|nmod|regulation aspects|nmod|combination combination|nmod|END_ENTITY	Physiological aspects of the combination of insulin and GLP-1 in the regulation of blood glucose control .
2677680	0	glucose	16,23	insulin	81,88	glucose	insulin	MESH:D005947	3630	Chemical	Gene	gene|compound|START_ENTITY Expression|nmod|gene cloned|nsubj|Expression cloned|nmod|brain brain|nmod|models models|nmod|resistance resistance|compound|END_ENTITY	Expression of a glucose transporter gene cloned from brain in cellular models of insulin resistance : dexamethasone decreases transporter mRNA in primary cultured adipocytes .
2679108	0	glucose	30,37	insulin	5,12	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY affect|dobj|metabolism affect|nsubj|END_ENTITY	Does insulin affect placental glucose metabolism and transfer ?
2681497	0	glucose	87,94	insulin	49,56	glucose	insulin	MESH:D005947	3630	Chemical	Gene	load|compound|START_ENTITY profiles|nmod|load profiles|compound|END_ENTITY	Impaired_glucose_tolerance in Thai adults : serum insulin profiles after a 75 gram oral glucose load .
2688480	0	glucose	15,22	insulin	49,56	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY Impairment|nmod|metabolism Impairment|nmod|activity activity|compound|END_ENTITY	-LSB- Impairment of glucose metabolism and changes in insulin activity during open heart surgery -RSB- .
2692795	0	glucose	36,43	insulin	16,23	glucose	insulin	MESH:D005947	105613195	Chemical	Gene	Ontogeny|nmod|START_ENTITY Ontogeny|nmod|response response|compound|END_ENTITY	Ontogeny of the insulin response to glucose in fetal and adult sheep .
2698352	0	glucose	29,36	insulin	4,11	glucose	insulin	MESH:D005947	3630	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	The insulin response to oral glucose , concentrations of total cholesterol , triglycerides and uric_acid in women with idiopathic_hirsutism .
2698356	0	glucose	11,18	insulin	108,115	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|nmod|administration administration|compound|END_ENTITY	Whole body glucose metabolism in experimental insulin-dependent diabetes after initiation or termination of insulin administration .
26994512	0	glucose	116,123	insulin	82,89	glucose	insulin	MESH:D005947	3630	Chemical	Gene	concentrations|compound|START_ENTITY expression|nmod|concentrations expression|compound|END_ENTITY	PDX1 and ISL1 differentially coordinate with epigenetic modifications to regulate insulin gene expression in varied glucose concentrations .
27054297	0	glucose	71,78	insulin	8,15	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY spectrum|nmod|tolerance resistance|nmod|spectrum resistance|compound|END_ENTITY	Adipose insulin resistance in obese adolescents across the spectrum of glucose tolerance .
27059430	0	glucose	5,12	insulin	72,79	glucose	insulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY unravels|nsubj|test unravels|xcomp|circulating circulating|dobj|miRNAs miRNAs|acl|associated associated|nmod|resistance resistance|compound|END_ENTITY	Oral glucose tolerance test unravels circulating miRNAs associated with insulin resistance in obese preschoolers .
2849310	0	glucose	27,34	insulin	69,76	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY stimulation|nmod|metabolism stimulation|dep|exchange exchange|nmod|END_ENTITY	Independent stimulation of glucose metabolism and Na + - K + exchange by insulin in the human forearm .
2866056	0	glucose	97,104	insulin	40,47	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY subjects|nmod|tolerance assessing|nmod|subjects assessing|dobj|sensitivity sensitivity|compound|END_ENTITY	A comparison of 3 methods for assessing insulin sensitivity in subjects with normal and abnormal glucose tolerance .
2869694	0	glucose	12,19	insulin	59,66	glucose	insulin	MESH:D005947	3630	Chemical	Gene	infusion|compound|START_ENTITY Response|nmod|infusion Response|dep|role role|nmod|changes changes|nmod|concentration concentration|compound|END_ENTITY	Response to glucose infusion in humans : role of changes in insulin concentration .
2875083	0	glucose	48,55	insulin	8,15	glucose	insulin	MESH:D005947	3630	Chemical	Gene	kinetics|compound|START_ENTITY response|nmod|kinetics Role|nmod|response Role|nmod|END_ENTITY	Role of insulin and glucagon in the response of glucose and alanine kinetics in burn-injured patients .
2878938	0	glucose	80,87	insulin	40,47	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	concentration|compound|START_ENTITY suppression|nmod|concentration suppression|nmod|END_ENTITY	Relationship of glucagon suppression by insulin and somatostatin to the ambient glucose concentration .
2946637	4	glucose	1186,1193	insulin	1351,1358	glucose	insulin	MESH:D005947	3630	Chemical	Gene	clearance|compound|START_ENTITY demonstrated|nmod|clearance demonstrated|advcl|suppressed suppressed|nmod|END_ENTITY	Compared to 8 non-diabetic subjects , type 1-diabetics demonstrated a diminished effect of hyperinsulinemia on peripheral glucose clearance -LRB- 2.4 + / - 0.04 vs 4.2 + / - 0.5 ml/kg X min , P less than 0.01 -RRB- , whereas hepatic_glucose_production and plasma FFA levels were similarly suppressed by insulin .
2974939	0	glucose	137,144	insulin	86,93	glucose	insulin	MESH:D005947	105613195	Chemical	Gene	exchange|compound|START_ENTITY regulating|dobj|exchange determine|advcl|regulating determine|dobj|role role|nmod|levels levels|nmod|END_ENTITY	Use of fetal streptozotocin injection to determine the role of normal levels of fetal insulin in regulating uteroplacental and umbilical glucose exchange .
2975568	0	glucose	52,59	insulin	29,36	glucose	insulin	MESH:D005947	3630	Chemical	Gene	transport|compound|START_ENTITY sensitivity|nmod|transport sensitivity|compound|END_ENTITY	A mixed meal potentiates the insulin sensitivity of glucose transport and metabolism in adipocytes from patients with type_2_diabetes_mellitus .
2976647	0	glucose	51,58	insulin	15,22	glucose	insulin	MESH:D005947	3630	Chemical	Gene	levels|compound|START_ENTITY falling|dobj|levels secretion|acl|falling secretion|compound|END_ENTITY	Suppression of insulin secretion by falling plasma glucose levels is impaired_in_type_2_diabetes .
3002669	7	glucose	1299,1306	insulin	1167,1174	glucose	insulin	MESH:D005947	3630	Chemical	Gene	response|nmod|START_ENTITY insulin|nmod|response release|nmod|insulin independent|nsubj|release mediated|advcl|independent mediated|nsubjpass|effect effect|nmod|adrenaline adrenaline|nmod|release release|compound|END_ENTITY	Therefore the effect of adrenaline on insulin release is mediated by way of inhibitory alpha 2 adrenoceptors in the pancreas , while the release of insulin in response to glucose in a resting subject is independent of the alpha-adrenergic system .
3028959	0	glucose	18,25	insulin	99,106	glucose	insulin	MESH:D005947	3630	Chemical	Gene	ACTH|nmod|START_ENTITY Effect|nmod|ACTH uptake|nsubj|Effect uptake|nmod|enzymes enzymes|nmod|presence presence|nmod|END_ENTITY	Effect of ACTH on glucose uptake by hepatic cells and its effect on hepatic enzymes in presence of insulin and acetylcholine .
3048098	0	glucose	96,103	insulin	64,71	glucose	insulin	MESH:D005947	3630	Chemical	Gene	reverses|nmod|START_ENTITY reverses|dobj|variation variation|nmod|response response|compound|END_ENTITY	Gestational diabetes reverses the circadian variation of plasma insulin response to intravenous glucose .
3053748	0	glucose	110,117	insulin	11,18	glucose	insulin	MESH:D005947	3630	Chemical	Gene	administration|compound|START_ENTITY closely|nmod|administration parallels|advmod|closely parallels|nsubj|END_ENTITY	Peripheral insulin parallels changes in insulin secretion more closely than C-peptide after bolus intravenous glucose administration .
3053748	0	glucose	110,117	insulin	40,47	glucose	insulin	MESH:D005947	3630	Chemical	Gene	administration|compound|START_ENTITY closely|nmod|administration parallels|advmod|closely parallels|dobj|changes changes|nmod|secretion secretion|compound|END_ENTITY	Peripheral insulin parallels changes in insulin secretion more closely than C-peptide after bolus intravenous glucose administration .
3054432	0	glucose	46,53	insulin	4,11	glucose	insulin	MESH:D005947	3630	Chemical	Gene	meals|nmod|START_ENTITY responses|nmod|meals responses|compound|END_ENTITY	The insulin and glucose responses to meals of glucose plus various proteins in type II diabetic subjects .
3064959	0	glucose	11,18	insulin	53,60	glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|nsubj|START_ENTITY control|nmod|persons persons|acl|using using|dobj|END_ENTITY	Meticulous glucose control in diabetic persons using insulin .
3065105	0	glucose	69,76	insulin	36,43	glucose	insulin	MESH:D005947	3630	Chemical	Gene	children|compound|START_ENTITY responses|dep|children responses|compound|END_ENTITY	The pattern of basal and stimulated insulin responses to intravenous glucose in first degree relatives of type 1 -LRB- insulin-dependent -RRB- diabetic children and unrelated adults aged 5 to 50 years .
3065113	0	glucose	42,49	insulin	10,17	glucose	insulin	MESH:D005947	3630	Chemical	Gene	acute|nmod|START_ENTITY acute|dobj|response response|compound|END_ENTITY	Low acute insulin response to intravenous glucose .
3069769	0	glucose	117,124	insulin	46,53	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY marker|nmod|tolerance marker|nsubj|level level|compound|END_ENTITY	Coronary_heart_disease mortality risk : plasma insulin level is a more sensitive marker than hypertension or abnormal glucose tolerance in overweight males .
3076501	0	glucose	14,21	insulin	58,65	glucose	insulin	MESH:D005947	3630	Chemical	Gene	Comparison|nmod|START_ENTITY meal-induced|nsubj|Comparison meal-induced|dobj|release release|compound|END_ENTITY	Comparison of glucose , glucagon and standard meal-induced insulin release in patients with newly onset non-insulin-dependent_diabetes_mellitus .
3077897	0	glucose	80,87	insulin	71,78	glucose	insulin	MESH:D005947	105613195	Chemical	Gene	kinetics|dep|START_ENTITY kinetics|compound|END_ENTITY	Experimental diabetes in lactating sheep : effects of alloxan on plasma insulin , glucose , glucose kinetics and milk characteristics .
3077897	0	glucose	89,96	insulin	71,78	glucose	insulin	MESH:D005947	105613195	Chemical	Gene	kinetics|dep|START_ENTITY kinetics|compound|END_ENTITY	Experimental diabetes in lactating sheep : effects of alloxan on plasma insulin , glucose , glucose kinetics and milk characteristics .
3078228	0	glucose	11,18	insulin	121,128	glucose	insulin	MESH:D005947	280829(Tax:9913)	Chemical	Gene	homeostasis|compound|START_ENTITY Control|nmod|homeostasis Control|dep|use use|nmod|ewe ewe|acl|study study|dobj|effects effects|nmod|END_ENTITY	Control of glucose homeostasis in lactating ewes : use of the alloxan-diabetic/insulin-stabilized ewe to study effects of insulin and growth_hormone .
3080654	0	glucose	53,60	insulin	34,41	glucose	insulin	MESH:D005947	3630	Chemical	Gene	storage|compound|START_ENTITY action|nmod|storage action|compound|END_ENTITY	Overnutrition induced decrease in insulin action for glucose storage : in vivo and in vitro in man .
3080654	2	glucose	407,414	insulin	388,395	glucose	insulin	MESH:D005947	3630	Chemical	Gene	disposal|compound|START_ENTITY action|nmod|disposal action|compound|END_ENTITY	After two weeks of weight maintenance and again after two weeks of 62 % greater caloric intake -LRB- constant ratio of fat : carbohydrate : protein -RRB- , insulin action for glucose disposal was measured using the euglycemic clamp technique with plasma insulin concentrations of about 110 and 1800 uU/mL .
3081885	3	glucose	557,564	insulin	632,639	glucose	insulin	MESH:D005947	3630	Chemical	Gene	administration|compound|START_ENTITY insulin|nmod|administration rise|nmod|insulin absent|nsubj|rise absent|advcl|reached reached|nsubj|level level|compound|END_ENTITY	A peak rise of insulin after glucose administration was absent in patients managed with SLD , whereas an insulin level during the arginine test reached 302 + / - 12.7 pmol/l .
3092500	0	glucose	7,14	insulin	25,32	glucose	insulin	MESH:D005947	3630	Chemical	Gene	START_ENTITY|dobj|levels levels|compound|END_ENTITY	-LSB- Blood glucose and serum insulin levels in newborn infants of diabetic mothers during feeding with an oligosaccharide mixture -RSB- .
3123287	0	glucose	34,41	insulin	10,17	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY immunization|nmod|tolerance immunization|nsubj|Effect Effect|nmod|END_ENTITY	Effect of insulin immunization on glucose tolerance in normal rats .
3154642	0	glucose	47,54	insulin	77,84	glucose	insulin	MESH:D005947	3630	Chemical	Gene	release|amod|START_ENTITY release|compound|END_ENTITY	Lack of effect of nicardipine and diltiazem on glucose - and arginine-induced insulin release in obese subjects .
3176815	0	glucose	46,53	insulin	24,31	glucose	insulin	MESH:D005947	3630	Chemical	Gene	utilization|compound|START_ENTITY resistance|nmod|utilization resistance|compound|END_ENTITY	Characterization of the insulin resistance of glucose utilization in adipocytes from patients with hyper - _ and_hypothyroidism .
3279811	0	glucose	47,54	insulin	58,65	glucose	insulin	MESH:D005947	3630	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|secretion secretion|compound|END_ENTITY	Dose-dependent effects of oral and intravenous glucose on insulin secretion and clearance in normal humans .
3286329	0	glucose	34,41	insulin	14,21	glucose	insulin	MESH:D005947	3630	Chemical	Gene	Maturation|acl|START_ENTITY Maturation|nmod|response response|compound|END_ENTITY	Maturation of insulin response to glucose during human fetal and neonatal development .
3287321	0	glucose	49,56	insulin	11,18	glucose	insulin	MESH:D005947	105613195	Chemical	Gene	utilization|compound|START_ENTITY Effects|nmod|utilization Effects|nmod|concentrations concentrations|compound|END_ENTITY	Effects of insulin and glucose concentrations on glucose utilization in fetal sheep .
3287951	0	glucose	35,42	insulin	16,23	glucose	insulin	MESH:D005947	3630	Chemical	Gene	production|compound|START_ENTITY effects|nmod|production effects|nsubj|Preservation Preservation|nmod|END_ENTITY	Preservation of insulin effects on glucose production and proteolysis during fasting .
3289995	0	glucose	38,45	insulin	98,105	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	production|compound|START_ENTITY sustaining|dobj|production gluconeogenesis|acl|sustaining Role|nmod|gluconeogenesis caused|nsubj|Role caused|nmod|infusion infusion|compound|END_ENTITY	Role of gluconeogenesis in sustaining glucose production during hypoglycemia caused by continuous insulin infusion in conscious dogs .
3292558	0	glucose	116,123	insulin	16,23	glucose	insulin	MESH:D005947	3630	Chemical	Gene	changes|nmod|START_ENTITY relationship|nmod|changes Oscillations|dep|relationship Oscillations|nmod|secretion secretion|compound|END_ENTITY	Oscillations in insulin secretion during constant glucose infusion in normal man : relationship to changes in plasma glucose .
3292558	0	glucose	50,57	insulin	16,23	glucose	insulin	MESH:D005947	3630	Chemical	Gene	infusion|compound|START_ENTITY secretion|nmod|infusion secretion|compound|END_ENTITY	Oscillations in insulin secretion during constant glucose infusion in normal man : relationship to changes in plasma glucose .
3296134	0	glucose	47,54	insulin	15,22	glucose	insulin	MESH:D005947	3630	Chemical	Gene	Impaired|nmod|START_ENTITY Impaired|dobj|response response|compound|END_ENTITY	Impaired early insulin response to intravenous glucose in alcoholic_liver_cirrhosis .
3296661	12	glucose	1585,1592	insulin	1558,1565	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	levels|compound|START_ENTITY rose|nmod|levels rose|nsubj|levels levels|compound|END_ENTITY	The insulin levels rose before glucose levels suggesting that oxytocin stimulates the release of insulin without a previous rise in glucose levels .
3296661	12	glucose	1686,1693	insulin	1558,1565	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	levels|compound|START_ENTITY rise|nmod|levels stimulates|nmod|rise suggesting|ccomp|stimulates rose|xcomp|suggesting rose|nsubj|levels levels|compound|END_ENTITY	The insulin levels rose before glucose levels suggesting that oxytocin stimulates the release of insulin without a previous rise in glucose levels .
3301158	0	glucose	21,28	insulin	117,124	glucose	insulin	MESH:D005947	3630	Chemical	Gene	infusion|compound|START_ENTITY secretion|nmod|infusion secretion|advcl|flanking flanking|dobj|gene gene|compound|END_ENTITY	Insulin secretion to glucose infusion in gestational diabetes subjects with differing DNA polymorphisms flanking the insulin gene .
3301168	2	glucose	297,304	insulin	166,173	glucose	insulin	MESH:D005947	3630	Chemical	Gene	uptake|compound|START_ENTITY insulin|nmod|uptake indicate|nmod|insulin indicate|nsubj|changes changes|nmod|metabolism metabolism|compound|END_ENTITY	Previous studies have claimed that changes in insulin and glucose metabolism in patients with peripheral arterial_insufficiency indicate an increased sensitivity to insulin for glucose uptake .
3301482	0	glucose	125,132	insulin	40,47	glucose	insulin	MESH:D005947	3630	Chemical	Gene	dynamics|compound|START_ENTITY model|nmod|dynamics using|dobj|model test|xcomp|using test|nsubj|Derivation Derivation|nmod|measure measure|nmod|sensitivity sensitivity|compound|END_ENTITY	Derivation of a quantitative measure of insulin sensitivity from the intravenous tolbutamide test using the minimal model of glucose dynamics .
3307452	0	glucose	42,49	insulin	81,88	glucose	insulin	MESH:D005947	3630	Chemical	Gene	transport|compound|START_ENTITY sensitivities|nmod|transport Dissociation|nmod|sensitivities Dissociation|nmod|END_ENTITY	Dissociation of in vitro sensitivities of glucose transport and antilipolysis to insulin in NIDDM .
3307584	0	glucose	49,56	insulin	19,26	glucose	insulin	MESH:D005947	3630	Chemical	Gene	excursions|compound|START_ENTITY improves|dobj|excursions improves|nsubj|END_ENTITY	Biosynthetic human insulin improves postprandial glucose excursions in type I diabetics .
3308958	0	glucose	31,38	insulin	20,27	glucose	insulin	MESH:D005947	3630	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|nmod|transport	Long-term effect of insulin on glucose transport and insulin binding in cultured adipocytes from normal and obese humans with and without non-insulin-dependent_diabetes .
3319860	0	glucose	6,13	insulin	117,124	glucose	insulin	MESH:D005947	3630	Chemical	Gene	START_ENTITY|nmod|administration administration|nmod|insulin insulin|nmod|syringe syringe|nmod|END_ENTITY	Blood glucose and free insulin levels after the administration of insulin by conventional syringe or jet injector in insulin treated type 2 diabetics .
3319860	0	glucose	6,13	insulin	66,73	glucose	insulin	MESH:D005947	3630	Chemical	Gene	START_ENTITY|nmod|administration administration|nmod|END_ENTITY	Blood glucose and free insulin levels after the administration of insulin by conventional syringe or jet injector in insulin treated type 2 diabetics .
3320007	2	glucose	245,252	insulin	187,194	glucose	insulin	MESH:D005947	3630	Chemical	Gene	uptake|compound|START_ENTITY increase|nmod|uptake explains|dobj|increase explains|nsubj|END_ENTITY	Whether the enhanced insulin binding explains the exercise-induced increase in glucose uptake is unclear , since insulin binding and glucose uptake have not been measured simultaneously in a target tissue of insulin .
3322729	0	glucose	60,67	insulin	103,110	glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY control|nmod|algorithm algorithm|nmod|adjustment adjustment|compound|END_ENTITY	Postoperative management of diabetes_mellitus : steady-state glucose control with bedside algorithm for insulin adjustment .
3326305	0	glucose	6,13	insulin	25,32	glucose	insulin	MESH:D005947	3630	Chemical	Gene	responses|compound|START_ENTITY responses|compound|END_ENTITY	Blood glucose and plasma insulin responses to fat-free milk and low-lactose fat-free milk in young type 1 diabetics .
3403714	1	glucose	102,109	insulin	79,86	glucose	insulin	MESH:D005947	3630	Chemical	Gene	transport|compound|START_ENTITY stimulation|nmod|transport stimulation|compound|END_ENTITY	Decreased insulin stimulation of glucose transport in muscle from morbidly obese and diabetic subjects .
347739	0	glucose	22,29	insulin	111,118	glucose	insulin	MESH:D005947	3630	Chemical	Gene	Response|nmod|START_ENTITY Response|nmod|END_ENTITY	Response of the blood glucose and the pancreatic islets of the lizard , Uromastix hardwicki -LRB- Gray -RRB- to exogenous insulin .
3510463	0	glucose	44,51	insulin	4,11	glucose	insulin	MESH:D005947	3630	Chemical	Gene	load|compound|START_ENTITY response|nmod|load response|compound|END_ENTITY	The insulin and glucose response to an oral glucose load in non-insulin-dependent_diabetes in the young .
3510926	0	glucose	17,24	insulin	80,87	glucose	insulin	MESH:D005947	100009181(Tax:9986)	Chemical	Gene	START_ENTITY|nmod|iontophoresis iontophoresis|nmod|END_ENTITY	Control of blood glucose levels in alloxan-diabetic rabbits by iontophoresis of insulin .
3512210	0	glucose	67,74	insulin	98,105	glucose	insulin	MESH:D005947	3630	Chemical	Gene	self-monitoring|nmod|START_ENTITY self-monitoring|nmod|dosage dosage|compound|END_ENTITY	Personal computer programs to assist with self-monitoring of blood glucose and self-adjustment of insulin dosage .
3514649	0	glucose	21,28	insulin	10,17	glucose	insulin	MESH:D005947	3630	Chemical	Gene	uptake|compound|START_ENTITY Effect|nmod|uptake Effect|nmod|END_ENTITY	Effect of insulin on glucose uptake and metabolism in the human placenta .
3514652	0	glucose	95,102	insulin	51,58	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY subjects|nmod|tolerance resistance|nmod|subjects resistance|compound|END_ENTITY	Glucose storage is a major determinant of in vivo `` insulin resistance '' in subjects with normal glucose tolerance .
3515118	0	glucose	10,17	insulin	67,74	glucose	insulin	MESH:D005947	3630	Chemical	Gene	concentrations|amod|START_ENTITY concentrations|nmod|END_ENTITY	Basal and glucose - and arginine-stimulated serum concentrations of insulin , C-peptide , and glucagon in hyperthyroid patients .
3516161	0	glucose	77,84	insulin	34,41	glucose	insulin	MESH:D005947	3630	Chemical	Gene	ingestion|compound|START_ENTITY circulation|nmod|ingestion regulates|nmod|circulation regulates|dobj|level level|compound|END_ENTITY	3,5,3 ' - Triiodothyronine regulates insulin level in the circulation following glucose ingestion in humans .
3516677	3	glucose	476,483	insulin	455,462	glucose	insulin	MESH:D005947	100060077(Tax:9796)	Chemical	Gene	loading|compound|START_ENTITY exhibited|nmod|loading exhibited|dobj|response response|nmod|levels levels|compound|END_ENTITY	These ponies also exhibited a far greater response in plasma insulin levels after glucose loading .
3516960	4	glucose	1533,1540	insulin	1655,1662	glucose	insulin	MESH:D005947	3630	Chemical	Gene	rates|amod|START_ENTITY similar|nsubj|rates similar|nmod|infusion infusion|nmod|spite spite|nmod|concentrations concentrations|nmod|END_ENTITY	Obese heifers were less responsive to insulin since hyperinsulinemia and euglycemia coexisted , and because glucose fractional removal rates were similar in both groups after glucose infusion in spite of greater concentrations of insulin in obese heifers .
3516960	4	glucose	1600,1607	insulin	1655,1662	glucose	insulin	MESH:D005947	3630	Chemical	Gene	infusion|compound|START_ENTITY infusion|nmod|spite spite|nmod|concentrations concentrations|nmod|END_ENTITY	Obese heifers were less responsive to insulin since hyperinsulinemia and euglycemia coexisted , and because glucose fractional removal rates were similar in both groups after glucose infusion in spite of greater concentrations of insulin in obese heifers .
3517013	0	glucose	25,32	insulin	47,54	glucose	insulin	MESH:D005947	396145(Tax:9031)	Chemical	Gene	stimulation|nmod|START_ENTITY metabolism|nsubj|stimulation metabolism|nmod|END_ENTITY	Transient stimulation of glucose metabolism by insulin in the 1-day chick embryo .
3517029	0	glucose	79,86	insulin	36,43	glucose	insulin	MESH:D005947	3630	Chemical	Gene	regard|nmod|START_ENTITY characterized|nmod|regard characterized|nmod|resistance resistance|compound|END_ENTITY	Type_I_diabetes is characterized by insulin resistance not only with regard to glucose , but also to lipid and amino_acid metabolism .
3517089	0	glucose	80,87	insulin	50,57	glucose	insulin	MESH:D005947	280829(Tax:9913)	Chemical	Gene	injection|compound|START_ENTITY Effect|nmod|injection Effect|nmod|END_ENTITY	Effect of season and stage of lactation on plasma insulin and glucose following glucose injection in Holstein cattle .
3519338	0	glucose	44,51	insulin	21,28	glucose	insulin	MESH:D005947	3630	Chemical	Gene	load|compound|START_ENTITY immunoreactive|nmod|load immunoreactive|dobj|responses responses|compound|END_ENTITY	Serum immunoreactive insulin responses to a glucose load in Asian Indian and European type 2 -LRB- non-insulin-dependent -RRB- diabetic patients and control subjects .
3519650	0	glucose	97,104	insulin	63,70	glucose	insulin	MESH:D005947	3630	Chemical	Gene	concentration|compound|START_ENTITY depends|nmod|concentration depends|nsubj|function function|nmod|hormones hormones|dep|interaction interaction|nmod|END_ENTITY	Glucoregulatory function of thyroid hormones : interaction with insulin depends on the prevailing glucose concentration .
3520129	0	glucose	53,60	insulin	89,96	glucose	insulin	MESH:D005947	3630	Chemical	Gene	maltitol|nmod|START_ENTITY levels|amod|maltitol levels|compound|END_ENTITY	Effects of oral administration of maltitol on plasma glucose , plasma sorbitol , and serum insulin levels in man .
3522319	0	glucose	68,75	insulin	47,54	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Relative importance of first - and second-phase insulin secretion in glucose homeostasis in conscious dog .
3526319	0	glucose	66,73	insulin	9,16	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	reabsorption|nmod|START_ENTITY regulation|nmod|reabsorption END_ENTITY|nmod|regulation	-LSB- Role of insulin in the regulation of the tubular reabsorption of glucose in the kidneys -RSB- .
3530110	0	glucose	111,118	insulin	76,83	glucose	insulin	MESH:D005947	3630	Chemical	Gene	loading|compound|START_ENTITY responsible|nmod|loading responsible|nmod|levels levels|compound|END_ENTITY	Insulin metabolism is a major factor responsible for high or low peripheral insulin levels in response to oral glucose loading in the healthy man .
353075	1	glucose	85,92	insulin	119,126	glucose	insulin	MESH:D005947	3630	Chemical	Gene	sensitivity|compound|START_ENTITY sensitivity|nmod|sensitivity sensitivity|nmod|END_ENTITY	Quantification of pancreatic beta cell sensitivity to glucose and tissue sensitivity to insulin .
3532820	0	glucose	37,44	insulin	17,24	glucose	insulin	MESH:D005947	105613195	Chemical	Gene	kinetics|compound|START_ENTITY infusion|nmod|kinetics infusion|compound|END_ENTITY	Effects of fetal insulin infusion on glucose kinetics in pregnant sheep : a compartmental analysis .
3532975	0	glucose	90,97	insulin	14,21	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	autotransplantation|nmod|START_ENTITY secretion|nmod|autotransplantation secretion|compound|END_ENTITY	Evaluation of insulin secretion after pancreas autotransplantation by oral or intravenous glucose challenge .
3538125	0	glucose	83,90	insulin	64,71	glucose	insulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY END_ENTITY|nmod|test	-LSB- Preliminary considerations on blood lipid parameters and blood insulin after oral glucose tolerance test -RSB- .
3540080	0	glucose	103,110	insulin	22,29	glucose	insulin	MESH:D005947	3630	Chemical	Gene	response|nmod|START_ENTITY determinant|nmod|response determinant|nsubj|evidence evidence|dep|metabolism metabolism|compound|END_ENTITY	Further evidence that insulin metabolism is a major determinant of peripheral insulin response to oral glucose in subjects with mild glucose_intolerance .
3540080	0	glucose	103,110	insulin	78,85	glucose	insulin	MESH:D005947	3630	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Further evidence that insulin metabolism is a major determinant of peripheral insulin response to oral glucose in subjects with mild glucose_intolerance .
3540081	0	glucose	66,73	insulin	40,47	glucose	insulin	MESH:D005947	3630	Chemical	Gene	load|compound|START_ENTITY Effect|nmod|load Effect|nmod|release release|nmod|END_ENTITY	Effect of domperidone on the release of insulin after intravenous glucose load in man .
3542456	3	glucose	523,530	insulin	445,452	glucose	insulin	MESH:D005947	3630	Chemical	Gene	measurement|nmod|START_ENTITY collected|nmod|measurement collected|nmod|injection injection|compound|END_ENTITY	Blood was collected before insulin injection and at hourly intervals subsequently for the measurement of glucose and insulin .
3542653	0	glucose	61,68	insulin	126,133	glucose	insulin	MESH:D005947	3630	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|patients patients|nmod|resistance resistance|compound|END_ENTITY	Adverse effects of insulin antibodies on postprandial plasma glucose and insulin profiles in diabetic patients without immune insulin resistance .
3542653	0	glucose	61,68	insulin	19,26	glucose	insulin	MESH:D005947	3630	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|antibodies antibodies|compound|END_ENTITY	Adverse effects of insulin antibodies on postprandial plasma glucose and insulin profiles in diabetic patients without immune insulin resistance .
3546167	0	glucose	68,75	insulin	24,31	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY encapsulated|nmod|metabolism encapsulated|nsubj|comparison comparison|nmod|END_ENTITY	A comparison of regular insulin and vesicle encapsulated insulin on glucose metabolism in diabetic subjects .
3546167	0	glucose	68,75	insulin	57,64	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY encapsulated|nmod|metabolism encapsulated|dobj|END_ENTITY	A comparison of regular insulin and vesicle encapsulated insulin on glucose metabolism in diabetic subjects .
3552918	0	glucose	34,41	insulin	9,16	glucose	insulin	MESH:D005947	3630	Chemical	Gene	load|compound|START_ENTITY Study|nmod|load Study|nmod|response response|compound|END_ENTITY	Study of insulin response to oral glucose load after acute and chronic glycemic control in type 2 diabetic subjects .
3553253	0	glucose	65,72	insulin	12,19	glucose	insulin	MESH:D005947	280829(Tax:9913)	Chemical	Gene	challenge|compound|START_ENTITY Response|nmod|challenge Response|nmod|glucagon glucagon|compound|END_ENTITY	Response of insulin , glucagon , and growth hormone to intravenous glucose challenge in cows fed high fat diets .
367155	0	glucose	23,30	insulin	42,49	glucose	insulin	MESH:D005947	3630	Chemical	Gene	C-peptide|amod|START_ENTITY C-peptide|dep|END_ENTITY	A prospective study of glucose tolerance , insulin , C-peptide , and glucagon responses in patients with pancreatic_carcinoma .
371613	4	glucose	736,743	insulin	787,794	glucose	insulin	MESH:D005947	3630	Chemical	Gene	START_ENTITY|acl|lowering lowering|dobj|effect effect|nmod|END_ENTITY	On the other hand exercise potentiates the blood glucose lowering effect of subcutaneously injected insulin ; therefore precautions have to be taken in order to avoid hypoglycemia in insulin-dependent diabetics especially during and after more strenous exercise .
3870620	0	glucose	53,60	insulin	72,79	glucose	insulin	MESH:D005947	3630	Chemical	Gene	data|nmod|START_ENTITY evaluation|nmod|data controlled|nsubj|evaluation controlled|dobj|systems systems|compound|END_ENTITY	Simplified evaluation and documentation of data from glucose controlled insulin infusion systems -- artefact handling .
3881887	0	glucose	95,102	insulin	30,37	glucose	insulin	MESH:D005947	3630	Chemical	Gene	recovery|nmod|START_ENTITY free|nmod|recovery free|dobj|hormones hormones|compound|END_ENTITY	The importance of plasma free insulin and counterregulatory hormones for the recovery of blood glucose following hypoglycaemia in type 1 diabetics .
3883950	0	glucose	42,49	insulin	20,27	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY relationship|nmod|metabolism relationship|nmod|production production|compound|END_ENTITY	The relationship of insulin production to glucose metabolism in severe sepsis .
3886396	0	glucose	40,47	insulin	59,66	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY diuretic_piretanide|nmod|tolerance Effects|nmod|diuretic_piretanide Effects|appos|secretion secretion|compound|END_ENTITY	Effects of a new diuretic_piretanide on glucose tolerance , insulin secretion and 125I-insulin binding .
3894418	0	glucose	48,55	insulin	11,18	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent -LRB- type II -RRB- diabetes mellitus .
3894421	0	glucose	57,64	insulin	10,17	glucose	insulin	MESH:D005947	3630	Chemical	Gene	distribution|nmod|START_ENTITY Effect|nmod|distribution Effect|nmod|END_ENTITY	Effect of insulin on the distribution and disposition of glucose in man .
3895985	3	glucose	650,657	insulin	704,711	glucose	insulin	MESH:D005947	3630	Chemical	Gene	incorporation|compound|START_ENTITY showed|dobj|incorporation showed|nmod|END_ENTITY	Isolated pancreatic islets from squirrels killed during the weight gain phase had greater glucose-stimulated insulin secretion than those from weight_loss phase animals , and adipocytes showed significantly greater glucose incorporation into total lipid in response to insulin .
3896283	0	glucose	29,36	insulin	57,64	glucose	insulin	MESH:D005947	3630	Chemical	Gene	secretion|compound|START_ENTITY secretion|compound|END_ENTITY	The effect of nicardipine on glucose and drug-stimulated insulin secretion in normal volunteers .
3896898	0	glucose	32,39	insulin	58,65	glucose	insulin	MESH:D005947	3630	Chemical	Gene	administration|compound|START_ENTITY administration|nmod|action action|compound|END_ENTITY	Effects of intravenous and oral glucose administration on insulin action in human fat cells .
3898086	0	glucose	42,49	insulin	31,38	glucose	insulin	MESH:D005947	100009181(Tax:9986)	Chemical	Gene	uptake|compound|START_ENTITY binding|nmod|uptake binding|nmod|END_ENTITY	Insulin binding and effects of insulin on glucose uptake and metabolism in cultured rabbit coronary microvessel endothelium .
3899766	0	glucose	21,28	insulin	64,71	glucose	insulin	MESH:D005947	3630	Chemical	Gene	effect|nmod|START_ENTITY control|nsubj|effect control|nmod|infusion infusion|compound|END_ENTITY	The effect of plasma glucose control by continuous subcutaneous insulin infusion or conventional therapy on retinal morphology and urinary albumin excretion .
3899825	0	glucose	92,99	insulin	30,37	glucose	insulin	MESH:D005947	3630	Chemical	Gene	fasting|dobj|START_ENTITY resistance|acl|fasting resistance|compound|END_ENTITY	Homeostasis model assessment : insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man .
3900136	0	glucose	84,91	insulin	14,21	glucose	insulin	MESH:D005947	3630	Chemical	Gene	effect|nmod|START_ENTITY responsible|nmod|effect responsible|nsubj|Evidence Evidence|dep|resistance resistance|compound|END_ENTITY	Evidence that insulin resistance is responsible for the decreased thermic effect of glucose in human obesity .
3908398	0	glucose	66,73	insulin	37,44	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY END_ENTITY|nmod|tolerance	Relative potencies of human and pork insulin during i.v. and oral glucose tolerance test in lean and obese persons .
3912487	0	glucose	47,54	insulin	111,118	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	response|compound|START_ENTITY describing|dobj|response describing|nmod|infusion infusion|compound|END_ENTITY	Evaluation of the Bolie model describing blood glucose response for the application to continuous subcutaneous insulin infusion .
3915271	0	glucose	62,69	insulin	42,49	glucose	insulin	MESH:D005947	3630	Chemical	Gene	increases|nmod|START_ENTITY increases|dobj|response response|compound|END_ENTITY	Gliclazide on long-term therapy increases insulin response to glucose of type_II_diabetics .
3923840	0	glucose	58,65	insulin	47,54	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	kinetics|compound|START_ENTITY modulate|nmod|kinetics modulate|dobj|effect effect|nmod|END_ENTITY	Indomethacin and salicylate modulate effect of insulin on glucose kinetics in dogs .
3936737	1	glucose	132,139	insulin	148,155	glucose	insulin	MESH:D005947	3630	Chemical	Gene	release|compound|START_ENTITY release|compound|END_ENTITY	Interactions between naloxone , phentolamine and lysine_acetylsalicylate upon glucose induced insulin release .
395069	0	glucose	81,88	insulin	100,107	glucose	insulin	MESH:D005947	3630	Chemical	Gene	controlled|advmod|START_ENTITY system|amod|controlled system|compound|END_ENTITY	Insulin treatment and state of control before , during , and after connection to a glucose controlled insulin infusion system -LRB- Biostator -RRB- .
395094	0	glucose	75,82	insulin	13,20	glucose	insulin	MESH:D005947	3630	Chemical	Gene	cell|nmod|START_ENTITY kinetics|nmod|cell kinetics|compound|END_ENTITY	Influence of insulin infusion kinetics of an artificial beta cell on blood glucose control in insulin-dependent diabetics .
396706	0	glucose	14,21	insulin	39,46	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY Comparison|nmod|tolerance Comparison|appos|END_ENTITY	Comparison of glucose tolerance , serum insulin , serum lipids and skinfold thickness between 50 - and 60-year-old men .
398701	0	glucose	90,97	insulin	35,42	glucose	insulin	MESH:D005947	3630	Chemical	Gene	overloads|nmod|START_ENTITY secretion|nmod|overloads secretion|compound|END_ENTITY	-LSB- Examination of the early phase of insulin secretion with 3 successive small overloads of glucose -LRB- 5 g -RRB- in normal and obese subjects -RSB- .
400127	0	glucose	57,64	insulin	17,24	glucose	insulin	MESH:D005947	3630	Chemical	Gene	injection|nmod|START_ENTITY injection|nmod|END_ENTITY	Jet injection of insulin during self-monitoring of blood glucose .
400128	0	glucose	9,16	insulin	42,49	glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY control|dep|concentration concentration|compound|END_ENTITY	Diabetic glucose control : matching plasma insulin concentration to dietary and stress hyperglycemia .
403600	0	glucose	51,58	insulin	40,47	glucose	insulin	MESH:D005947	3630	Chemical	Gene	solutions|compound|START_ENTITY END_ENTITY|nmod|solutions	-LSB- Loss of insulin during the infusion of insulin in glucose and nutrient solutions -RSB- .
403600	0	glucose	51,58	insulin	9,16	glucose	insulin	MESH:D005947	3630	Chemical	Gene	solutions|compound|START_ENTITY insulin|nmod|solutions infusion|nmod|insulin END_ENTITY|nmod|infusion	-LSB- Loss of insulin during the infusion of insulin in glucose and nutrient solutions -RSB- .
4161613	0	glucose	33,40	insulin	71,78	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY Effect|nmod|tolerance Effect|nmod|END_ENTITY	Effect of abdominal operation on glucose tolerance and serum levels of insulin , growth_hormone , and hydrocortisone .
4164072	0	glucose	31,38	insulin	11,18	glucose	insulin	MESH:D005947	3630	Chemical	Gene	load|compound|START_ENTITY Failure|nmod|load Failure|nmod|response response|compound|END_ENTITY	Failure of insulin response to glucose load during operation and after myocardial_infarction .
4177392	0	glucose	33,40	insulin	11,18	glucose	insulin	MESH:D005947	3630	Chemical	Gene	absorption|compound|START_ENTITY Effects|nmod|absorption Effects|nmod|END_ENTITY	Effects of insulin on intestinal glucose absorption .
419917	0	glucose	9,16	insulin	55,62	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY Study|nmod|tolerance Study|nmod|secretion secretion|compound|END_ENTITY	Study of glucose tolerance and the dynamic property of insulin secretion .
4203504	0	glucose	22,29	insulin	11,18	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY Effects|nmod|metabolism Effects|nmod|END_ENTITY	Effects of insulin on glucose metabolism in vascular and intestinal smooth muscle .
4238184	0	glucose	41,48	insulin	52,59	glucose	insulin	MESH:D005947	3630	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|compound|END_ENTITY	-LSB- Effects of increasing concentrations of glucose on insulin secretion .
428685	0	glucose	9,16	insulin	28,35	glucose	insulin	MESH:D005947	3630	Chemical	Gene	Use|nmod|START_ENTITY controlled|nsubj|Use controlled|dobj|system system|compound|END_ENTITY	Use of a glucose controlled insulin infusion system -LRB- artificial beta cell -RRB- to control diabetes during surgery .
4287739	0	glucose	88,95	insulin	38,45	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY amino_acids|nmod|metabolism amino_acids|nsubj|observations observations|nmod|influence influence|nmod|END_ENTITY	Some observations on the influence of insulin , prednisolone and free amino_acids on the glucose metabolism in cultivated liver tissue .
4292884	0	glucose	42,49	insulin	11,18	glucose	insulin	MESH:D005947	3630	Chemical	Gene	transport|compound|START_ENTITY Effects|nmod|transport Effects|nmod|END_ENTITY	Effects of insulin and phospholipase_A on glucose transport across the plasma membrane of free adipose cells .
4311236	0	glucose	73,80	insulin	42,49	glucose	insulin	MESH:D005947	3630	Chemical	Gene	stimuli|compound|START_ENTITY man|nmod|stimuli component|nmod|man component|compound|END_ENTITY	Plasma insulin : fluctuations in the `` big '' insulin component in man after glucose and other stimuli .
4311236	0	glucose	73,80	insulin	7,14	glucose	insulin	MESH:D005947	3630	Chemical	Gene	stimuli|compound|START_ENTITY man|nmod|stimuli component|nmod|man fluctuations|nmod|component END_ENTITY|dep|fluctuations	Plasma insulin : fluctuations in the `` big '' insulin component in man after glucose and other stimuli .
446711	0	glucose	22,29	insulin	11,18	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|nmod|transport	-LSB- Effect of insulin on glucose transport in the kidneys -RSB- .
446919	0	glucose	58,65	insulin	33,40	glucose	insulin	MESH:D005947	3630	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Ethnic variability in the plasma insulin response to oral glucose in Polynesian and Micronesian subjects .
446920	0	glucose	17,24	insulin	84,91	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	START_ENTITY|nmod|means means|nmod|device device|compound|END_ENTITY	Control of blood glucose in experimental diabetes by means of a totally implantable insulin infusion device .
447855	0	glucose	46,53	insulin	11,18	glucose	insulin	MESH:D005947	3630	Chemical	Gene	injection|compound|START_ENTITY delivery|nmod|injection delivery|compound|END_ENTITY	Pattern of insulin delivery after intravenous glucose injection in man and its relation to plasma glucose_disappearance .
449698	0	glucose	80,87	insulin	11,18	glucose	insulin	MESH:D005947	3630	Chemical	Gene	load|compound|START_ENTITY glucagon|nmod|load glucagon|nsubj|Effects Effects|nmod|END_ENTITY	Effects of insulin on the response of immunoreactive glucagon to an intravenous glucose load in human diabetes .
4555783	0	glucose	44,51	insulin	23,30	glucose	insulin	MESH:D005947	3630	Chemical	Gene	responses|nmod|START_ENTITY responses|compound|END_ENTITY	Acute and steady-state insulin responses to glucose in nonobese diabetic subjects .
465540	0	glucose	21,28	insulin	90,97	glucose	insulin	MESH:D005947	396145(Tax:9031)	Chemical	Gene	insulin|nmod|START_ENTITY Effect|nmod|insulin oxidation|nsubj|Effect oxidation|dobj|transport transport|nmod|END_ENTITY	Effect of insulin on glucose oxidation and amino_isobutyric_acid transport and binding of insulin in chicken thymocytes .
4716490	0	glucose	26,33	insulin	45,52	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY variation|nmod|tolerance variation|dep|changes changes|compound|END_ENTITY	Diurnal variation on oral glucose tolerance : insulin and growth_hormone changes with special reference to women taking oral contraceptives .
4719675	0	glucose	24,31	insulin	72,79	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	administration|compound|START_ENTITY Effect|nmod|administration Effect|nmod|END_ENTITY	Effect of intraduodenal glucose administration on hepatic extraction of insulin in the anesthetized dog .
478182	0	glucose	87,94	insulin	76,83	glucose	insulin	MESH:D005947	100009181(Tax:9986)	Chemical	Gene	utilization|compound|START_ENTITY END_ENTITY|nmod|utilization	In vitro studies of the substrates for energy production and the effects of insulin on glucose utilization in the neural components of peripheral nerve .
4805339	0	glucose	44,51	insulin	7,14	glucose	insulin	MESH:D005947	3630	Chemical	Gene	response|nmod|START_ENTITY concentration|nmod|response concentration|compound|END_ENTITY	Plasma insulin concentration in response to glucose given by different routes .
4808648	2	glucose	79,86	insulin	60,67	glucose	insulin	MESH:D005947	3630	Chemical	Gene	concentration|compound|START_ENTITY concentration|compound|END_ENTITY	Influence of insulin and medium glucose concentration on cellular metabolism .
481365	0	glucose	30,37	insulin	49,56	glucose	insulin	MESH:D005947	3630	Chemical	Gene	dynamics|nmod|START_ENTITY controlled|nsubj|dynamics controlled|dobj|system system|compound|END_ENTITY	Feedback control dynamics for glucose controlled insulin infusion system .
484166	0	glucose	40,47	insulin	12,19	glucose	insulin	MESH:D005947	3630	Chemical	Gene	infusion|compound|START_ENTITY secretion|nmod|infusion secretion|compound|END_ENTITY	Kinetics of insulin secretion following glucose infusion in patients with atherosclerotic_peripheral_vascular_disease .
4891780	0	glucose	12,19	insulin	47,54	glucose	insulin	MESH:D005947	3630	Chemical	Gene	START_ENTITY|nmod|secretion secretion|nmod|END_ENTITY	-LSB- Effects of glucose on pancreatic secretion of insulin in vitro , in different species of rodents -RSB- .
4938132	0	glucose	67,74	insulin	47,54	glucose	insulin	MESH:D005947	3630	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Epinephrine : selective inhibition of the acute insulin response to glucose .
4971521	0	glucose	27,34	insulin	66,73	glucose	insulin	MESH:D005947	3630	Chemical	Gene	action|nmod|START_ENTITY sulfamides|nsubj|action sulfamides|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Synergetic action between glucose and hypotlycemic sulfamides on insulin secretion -RSB- .
5042478	0	glucose	21,28	insulin	10,17	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	Effect of insulin on glucose metabolism in cerebral cortex slices under aerobic and anerobic conditions .
5044225	0	glucose	33,40	insulin	22,29	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	Stimulatory effect of insulin on glucose metabolism of thymus lymphocytes .
5097575	0	glucose	56,63	insulin	24,31	glucose	insulin	MESH:D005947	3630	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Influence Influence|nmod|END_ENTITY	Influence of endogenous insulin secretion on splanchnic glucose and amino_acid metabolism in man .
5107145	0	glucose	100,107	insulin	158,165	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY tolerance|nmod|-RSB- -RSB-|amod|obesity obesity|nmod|standpoint standpoint|nmod|dynamics dynamics|compound|END_ENTITY	-LSB- Carbohydrate metabolism and hormones in obesity -- with special reference to the analysis of reduced glucose tolerance in obesity from the standpoint of serum insulin dynamics -RSB- .
5410388	0	glucose	25,32	insulin	14,21	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY effect|nmod|metabolism effect|nmod|END_ENTITY	The effect of insulin on glucose metabolism of the incubated human placenta .
5436255	0	glucose	119,126	insulin	11,18	glucose	insulin	MESH:D005947	3630	Chemical	Gene	absence|nmod|START_ENTITY added|nmod|absence added|nsubj|Effects Effects|nmod|END_ENTITY	Effects of insulin and norepinephrine added in vitro on the metabolism of brown adipose tissue in the absence of added glucose .
579023	1	glucose	147,154	insulin	95,102	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tests|compound|START_ENTITY levels|nmod|tests levels|compound|END_ENTITY	I. Glucose , insulin and human growth_hormone levels during oral glucose tolerance tests .
579584	0	glucose	54,61	insulin	130,137	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY judging|dobj|tolerance judging|nmod|measurements measurements|nmod|END_ENTITY	-LSB- The use of the discriminant analysis for judging the glucose tolerance of pregnant women by time-dependent measurements of serum insulin -LRB- author 's transl -RRB- -RSB- .
5855643	0	glucose	58,65	insulin	15,22	glucose	insulin	MESH:D005947	100379579(Tax:10141)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of insulin and adrenalin on the metabolism of glucose and lactate by perfused guinea_pig hearts .
5920806	0	glucose	15,22	insulin	73,80	glucose	insulin	MESH:D005947	3630	Chemical	Gene	Stimulation|nmod|START_ENTITY metabolism|nsubj|Stimulation metabolism|nmod|addition addition|nmod|END_ENTITY	Stimulation of glucose metabolism in brown adipose tissue by addition of insulin in vitro .
5948455	0	glucose	24,31	insulin	11,18	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	Effects of insulin upon glucose metabolism and protein synthesis by the anterior pituitary in vitro .
5968900	0	glucose	22,29	insulin	11,18	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	Effects of insulin on glucose metabolism by explants of mouse mammary gland maintained in organ culture .
6020731	0	glucose	34,41	insulin	57,64	glucose	insulin	MESH:D005947	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of pulse administration of glucose or glucagon on insulin secretion in vitro .
6030300	0	glucose	59,66	insulin	30,37	glucose	insulin	MESH:D005947	105613195	Chemical	Gene	metabolism|nmod|START_ENTITY END_ENTITY|nmod|metabolism	Effect of glucose load and of insulin on the metabolism of glucose and of palmitate in sheep .
603273	1	glucose	89,96	insulin	69,76	glucose	insulin	MESH:D005947	3630	Chemical	Gene	changes|nmod|START_ENTITY changes|xcomp|due due|nmod|operation operation|nmod|response response|compound|END_ENTITY	I. Early changes due to operation in the insulin response to glucose .
6054171	0	glucose	15,22	insulin	70,77	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY Studies|nmod|metabolism Studies|dep|effects effects|nmod|END_ENTITY	Studies on the glucose metabolism of human term placentas : effects of insulin .
6057488	0	glucose	22,29	insulin	11,18	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY Effects|nmod|metabolism Effects|nmod|END_ENTITY	Effects of insulin on glucose metabolism in isolated human fat cells .
6061732	0	glucose	86,93	insulin	26,33	glucose	insulin	MESH:D005947	3630	Chemical	Gene	response|nmod|START_ENTITY evaluation|nmod|response significance|nmod|evaluation significance|nmod|levels levels|compound|END_ENTITY	The significance of basal insulin levels in the evaluation of the insulin response to glucose in diabetic and nondiabetic subjects .
6061732	0	glucose	86,93	insulin	66,73	glucose	insulin	MESH:D005947	3630	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	The significance of basal insulin levels in the evaluation of the insulin response to glucose in diabetic and nondiabetic subjects .
6074000	0	glucose	49,56	insulin	7,14	glucose	insulin	MESH:D005947	3630	Chemical	Gene	responses|nmod|START_ENTITY responses|compound|END_ENTITY	Plasma insulin responses to oral and intravenous glucose : studies in normal and diabetic sujbjects .
6103856	0	glucose	56,63	insulin	65,72	glucose	insulin	MESH:D005947	3630	Chemical	Gene	glucagon|compound|START_ENTITY glucagon|dep|END_ENTITY	Streptozotocin diabetes in the monkey : plasma levels of glucose , insulin , glucagon , and somatostatin , with corresponding morphometric analysis of islet endocrine cells .
6112655	0	glucose	44,51	insulin	85,92	glucose	insulin	MESH:D005947	3630	Chemical	Gene	infusion|compound|START_ENTITY response|nmod|infusion response|dep|roles roles|nmod|END_ENTITY	The glucoregulatory response to intravenous glucose infusion in normal man : roles of insulin and glucose .
6121763	0	glucose	98,105	insulin	34,41	glucose	insulin	MESH:D005947	3630	Chemical	Gene	loading|compound|START_ENTITY glucagon|nmod|loading glucagon|nsubj|Effects Effects|nmod|cyclic_somatostatin cyclic_somatostatin|nmod|END_ENTITY	Effects of cyclic_somatostatin on insulin , C-peptide and immunoreactive glucagon response to oral glucose loading in obese patients .
6122102	0	glucose	53,60	insulin	33,40	glucose	insulin	MESH:D005947	3630	Chemical	Gene	regulation|compound|START_ENTITY affect|dobj|regulation affect|nsubj|sequences sequences|nmod|gene gene|compound|END_ENTITY	DNA insertion sequences near the insulin gene affect glucose regulation .
6123524	0	glucose	61,68	insulin	24,31	glucose	insulin	MESH:D005947	3630	Chemical	Gene	disposal|compound|START_ENTITY effects|nmod|disposal effects|nmod|END_ENTITY	Differential effects of insulin on splanchnic and peripheral glucose disposal after an intravenous glucose load in man .
6123524	0	glucose	99,106	insulin	24,31	glucose	insulin	MESH:D005947	3630	Chemical	Gene	load|compound|START_ENTITY disposal|nmod|load effects|nmod|disposal effects|nmod|END_ENTITY	Differential effects of insulin on splanchnic and peripheral glucose disposal after an intravenous glucose load in man .
6126816	1	glucose	241,248	insulin	203,210	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	stimulation|compound|START_ENTITY antagonists|nmod|stimulation antagonists|nmod|level level|compound|END_ENTITY	The effects of cardioselective and non-cardioselective beta-adrenoceptor antagonists with and without intrinsic sympathomimetic activity on basal insulin level and insulin level after glucose stimulation in normoglycemic dogs .
6132712	0	glucose	68,75	insulin	11,18	glucose	insulin	MESH:D005947	105613195	Chemical	Gene	production|nmod|START_ENTITY Effects|nmod|production Effects|nmod|END_ENTITY	Effects of insulin and glucose on the production and utilization of glucose in sheep -LRB- Ovis_aries -RRB- .
6146261	0	glucose	14,21	insulin	36,43	glucose	insulin	MESH:D005947	3630	Chemical	Gene	dependency|compound|START_ENTITY dependency|nmod|release release|compound|END_ENTITY	Difference in glucose dependency of insulin and somatostatin release .
6181562	0	glucose	14,21	insulin	96,103	glucose	insulin	MESH:D005947	3630	Chemical	Gene	marks|nsubj|START_ENTITY Evidence|dep|marks Evidence|dep|cells cells|acl|resulting resulting|nmod|release release|nmod|END_ENTITY	Evidence that glucose `` marks '' beta cells resulting in preferential release of newly synthesized insulin .
6253986	0	glucose	46,53	insulin	67,74	glucose	insulin	MESH:D005947	3630	Chemical	Gene	induction|compound|START_ENTITY induction|nmod|secretion secretion|compound|END_ENTITY	-LSB- Present-day concepts of the mechanism of the glucose induction of insulin secretion -RSB- .
6255805	0	glucose	100,107	insulin	80,87	glucose	insulin	MESH:D005947	3630	Chemical	Gene	inhibitors|nmod|START_ENTITY inhibitors|dobj|inhibition inhibition|nmod|response response|compound|END_ENTITY	Prostaglandin synthesis inhibitors reverse alpha-adrenergic inhibition of acute insulin response to glucose .
6262168	0	glucose	76,83	insulin	98,105	glucose	insulin	MESH:D005947	3630	Chemical	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Pathogenesis of hypoglycemia in insulinoma patients : suppression of hepatic glucose production by insulin .
6263106	0	glucose	50,57	insulin	12,19	glucose	insulin	MESH:D005947	3630	Chemical	Gene	transport|compound|START_ENTITY binding|nmod|transport binding|compound|END_ENTITY	Coupling of insulin binding and insulin action on glucose transport in fat cells .
6331036	0	glucose	39,46	insulin	58,65	glucose	insulin	MESH:D005947	3630	Chemical	Gene	guided|nmod|START_ENTITY test|acl|guided controlled|nsubj|test controlled|dobj|system system|compound|END_ENTITY	Insulin hypoglycaemia test guided by a glucose controlled insulin infusion system .
6337503	0	glucose	48,55	insulin	37,44	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	turnover|compound|START_ENTITY Effect|nmod|turnover Effect|nmod|END_ENTITY	Effect of intraportal and peripheral insulin on glucose turnover and recycling in diabetic dogs .
6337926	0	glucose	42,49	insulin	11,18	glucose	insulin	MESH:D005947	3630	Chemical	Gene	levels|compound|START_ENTITY END_ENTITY|nmod|levels	Effects of insulin and glucagon on plasma glucose levels and glycogen content in organs of the freshwater teleost Pimelodus maculatus .
6343014	0	glucose	63,70	insulin	19,26	glucose	insulin	MESH:D005947	3630	Chemical	Gene	days|nmod|START_ENTITY dosage|nmod|days dosage|compound|END_ENTITY	Reproducibility of insulin dosage on consecutive days of blood glucose control by an artificial beta-cell in brittle diabetic patients .
6343033	0	glucose	111,118	insulin	59,66	glucose	insulin	MESH:D005947	3630	Chemical	Gene	technique|compound|START_ENTITY assessed|nmod|technique assessed|advmod|as as|nmod:npmod|insulin insulin|compound|END_ENTITY	Comparison of the activity and pharmacokinetics of porcine insulin and human insulin -LRB- Novo -RRB- as assessed by the glucose clamp technique in normal and diabetic man .
6343033	0	glucose	111,118	insulin	77,84	glucose	insulin	MESH:D005947	3630	Chemical	Gene	technique|compound|START_ENTITY assessed|nmod|technique assessed|advmod|as as|nmod:npmod|END_ENTITY	Comparison of the activity and pharmacokinetics of porcine insulin and human insulin -LRB- Novo -RRB- as assessed by the glucose clamp technique in normal and diabetic man .
6345239	0	glucose	120,127	insulin	48,55	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY action|nmod|tolerance action|compound|END_ENTITY	Quantification of insulin secretion and in vivo insulin action in nonobese and moderately obese individuals with normal glucose tolerance .
6346435	0	glucose	154,161	insulin	25,32	glucose	insulin	MESH:D005947	3630	Chemical	Gene	turnover|compound|START_ENTITY measurement|nmod|turnover coupled|nmod|measurement technique|acl|coupled method|dep|technique method|nmod|sensitivity sensitivity|compound|END_ENTITY	A method for quantifying insulin sensitivity in vivo in the anesthetized rat : the euglycemic insulin clamp technique coupled with isotopic measurement of glucose turnover .
6346435	0	glucose	154,161	insulin	93,100	glucose	insulin	MESH:D005947	3630	Chemical	Gene	turnover|compound|START_ENTITY measurement|nmod|turnover coupled|nmod|measurement technique|acl|coupled technique|compound|END_ENTITY	A method for quantifying insulin sensitivity in vivo in the anesthetized rat : the euglycemic insulin clamp technique coupled with isotopic measurement of glucose turnover .
6350543	0	glucose	15,22	insulin	6,13	glucose	insulin	MESH:D005947	3630	Chemical	Gene	fructose|compound|START_ENTITY levels|compound|fructose END_ENTITY|appos|levels	Blood insulin , glucose , fructose and gastric inhibitory polypeptide levels in carbohydrate-sensitive and normal men given a sucrose or invert sugar tolerance test .
6352727	0	glucose	17,24	insulin	67,74	glucose	insulin	MESH:D005947	3630	Chemical	Gene	disposal|compound|START_ENTITY disposal|dep|evidence evidence|nmod|resistance resistance|compound|END_ENTITY	Insulin-mediated glucose disposal in type_I_diabetes : evidence for insulin resistance .
6353136	0	glucose	127,134	insulin	26,33	glucose	insulin	MESH:D005947	3630	Chemical	Gene	action|nmod|START_ENTITY action|nmod|END_ENTITY	The physiologic action of insulin on glucose_uptake and its relevance to the interpretation of the metabolic clearance rate of glucose .
6353825	0	glucose	34,41	insulin	13,20	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|nmod|START_ENTITY tolerance|compound|END_ENTITY	-LSB- Features of insulin tolerance to glucose in primary and secondary forms of progressive muscular_dystrophy -RSB- .
6354162	0	glucose	17,24	insulin	109,116	glucose	insulin	MESH:D005947	105613195	Chemical	Gene	Incorporation|nmod|START_ENTITY Incorporation|dep|influence influence|nmod|END_ENTITY	Incorporation of glucose into lipid of perirenal and subcutaneous adipocytes of rats and sheep : influence of insulin .
6368586	0	glucose	114,121	insulin	52,59	glucose	insulin	MESH:D005947	3630	Chemical	Gene	ingestion|compound|START_ENTITY obtained|nmod|ingestion obtained|nsubj|Influence Influence|nmod|obesity obesity|nmod|effect effect|nmod|END_ENTITY	Influence of obesity on the antilipolytic effect of insulin in isolated human fat cells obtained before and after glucose ingestion .
6370728	0	glucose	46,53	insulin	28,35	glucose	insulin	MESH:D005947	3630	Chemical	Gene	transport|compound|START_ENTITY hypothesis|nmod|transport hypothesis|nmod|action action|compound|END_ENTITY	Translocation hypothesis of insulin action on glucose transport .
6372181	0	glucose	55,62	insulin	11,18	glucose	insulin	MESH:D005947	397415(Tax:9823)	Chemical	Gene	oxidation|nmod|START_ENTITY Effect|nmod|oxidation Effect|nmod|END_ENTITY	-LSB- Effect of insulin and cortisol on oxidation of -LRB- 1-14C -RRB- glucose , -LRB- 6-14C -RRB- glucose , -LRB- 1-14C -RRB- palmitate and -LRB- 1-14C -RRB- leucine in the tissues of swine during the neonatal period -RSB- .
6372345	0	glucose	76,83	insulin	36,43	glucose	insulin	MESH:D005947	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|trauma trauma|nmod|END_ENTITY	Effect of surgical trauma on plasma insulin and somatostatin in response to glucose .
6373809	0	glucose	98,105	insulin	19,26	glucose	insulin	MESH:D005947	3630	Chemical	Gene	disposal|compound|START_ENTITY effects|nmod|disposal have|dobj|effects have|nsubj|END_ENTITY	Biosynthetic human insulin and proinsulin have additive but not synergistic effects on total body glucose disposal .
6377986	0	glucose	50,57	insulin	93,100	glucose	insulin	MESH:D005947	3630	Chemical	Gene	Duration|nmod|START_ENTITY Duration|nmod|overdoses overdoses|nmod|END_ENTITY	Duration of hypoglycemia and need for intravenous glucose following intentional overdoses of insulin .
6381189	0	glucose	41,48	insulin	60,67	glucose	insulin	MESH:D005947	3630	Chemical	Gene	START_ENTITY|acl|controlled controlled|dobj|system system|compound|END_ENTITY	A comparison of the artificial pancreas -LRB- glucose controlled insulin infusion system -RRB- and a manual technique for assessing insulin sensitivity during euglycaemic clamping .
6381274	0	glucose	12,19	insulin	31,38	glucose	insulin	MESH:D005947	3630	Chemical	Gene	START_ENTITY|dobj|response response|dep|END_ENTITY	Intravenous glucose tolerance , insulin response to glucose , peripheral sensitivity to insulin , and serum lipoproteins in post-myocardial_infarct patients with normal fasting blood_glucose .
6381274	0	glucose	51,58	insulin	31,38	glucose	insulin	MESH:D005947	3630	Chemical	Gene	glucose|nmod|START_ENTITY glucose|dobj|response response|dep|END_ENTITY	Intravenous glucose tolerance , insulin response to glucose , peripheral sensitivity to insulin , and serum lipoproteins in post-myocardial_infarct patients with normal fasting blood_glucose .
6383906	0	glucose	60,67	insulin	40,47	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	Effects of portal and peripheral venous insulin infusion on glucose production and utilization in depancreatized , conscious dogs .
6383936	0	glucose	12,19	insulin	46,53	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY Kinetics|nmod|metabolism Kinetics|nmod|concentrations concentrations|compound|END_ENTITY	Kinetics of glucose metabolism in relation to insulin concentrations in patients with alcoholic_cirrhosis and in healthy persons .
6386641	0	glucose	77,84	insulin	12,19	glucose	insulin	MESH:D005947	3630	Chemical	Gene	regulation|nmod|START_ENTITY role|nmod|regulation role|nmod|END_ENTITY	The role of insulin , glucagon and growth_hormone in the regulation of plasma glucose and free fatty_acid levels in anorexia_nervosa .
6387366	0	glucose	102,109	insulin	69,76	glucose	insulin	MESH:D005947	3630	Chemical	Gene	transport|compound|START_ENTITY transport|nmod|sensitivity sensitivity|compound|END_ENTITY	Insulin resistance in the aged : a quantitative evaluation of in vivo insulin sensitivity and in vitro glucose transport .
6388353	0	glucose	75,82	insulin	22,29	glucose	insulin	MESH:D005947	3630	Chemical	Gene	level|compound|START_ENTITY enhances|nmod|level enhances|nsubj|resistance resistance|compound|END_ENTITY	Dexamethasone-induced insulin resistance enhances B cell responsiveness to glucose level in normal men .
6392097	0	glucose	73,80	insulin	15,22	glucose	insulin	MESH:D005947	3630	Chemical	Gene	using|dobj|START_ENTITY lipolysis|acl|using resistance|nmod|lipolysis resistance|compound|END_ENTITY	-LSB- Postoperative insulin resistance of lipolysis and ketogenesis using the glucose clamp technic -RSB- .
6397030	0	glucose	56,63	insulin	37,44	glucose	insulin	MESH:D005947	3630	Chemical	Gene	load|compound|START_ENTITY peroral|dobj|load Responses|acl|peroral Responses|nmod|END_ENTITY	Responses of blood_glucose and serum insulin to peroral glucose load in normoglycemic twins .
6404377	0	glucose	62,69	insulin	20,27	glucose	insulin	MESH:D005947	3630	Chemical	Gene	concentrations|compound|START_ENTITY effect|nmod|concentrations Intermediate|dep|effect Intermediate|acl|acting acting|dobj|END_ENTITY	Intermediate acting insulin given at bedtime : effect on blood glucose concentrations before and after breakfast .
6416510	1	glucose	91,98	insulin	162,169	glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY obtained|nsubj|control obtained|advcl|compared compared|csubjpass|using using|dobj|_ _|compound|END_ENTITY	The blood glucose control obtained when using semi-synthetic monocomponent human insulin _ -LRB- insulin_A -RRB- was compared with that using standard monocomponent porcine insulin -LRB- insulin B -RRB- in 14 children in a double blind crossover study .
645900	0	glucose	11,18	insulin	61,68	glucose	insulin	MESH:D005947	3630	Chemical	Gene	system|compound|START_ENTITY Studies|nmod|system Studies|dep|effects effects|nmod|mimickers mimickers|compound|END_ENTITY	Studies of glucose transport system of fat cells : effects of insulin and insulin mimickers .
6468493	0	glucose	97,104	insulin	75,82	glucose	insulin	MESH:D005947	100009181(Tax:9986)	Chemical	Gene	utilization|compound|START_ENTITY resistance|nmod|utilization resistance|compound|END_ENTITY	Adrenal function and the action of propranolol in surgical stress-mediated insulin resistance of glucose utilization by peripheral tissues in vivo .
647213	0	glucose	78,85	insulin	23,30	glucose	insulin	MESH:D005947	3630	Chemical	Gene	production|compound|START_ENTITY effect|nmod|production Mechanism|dep|effect Mechanism|nmod|action action|nmod|END_ENTITY	Mechanism of action of insulin in diabetic patients : a dose-related effect on glucose production and utilisation .
6490795	0	glucose	64,71	insulin	104,111	glucose	insulin	MESH:D005947	3630	Chemical	Gene	disposal|compound|START_ENTITY disposal|nmod|vivo vivo|nmod|relation relation|nmod|END_ENTITY	Site of insulin resistance in type 1 diabetes : insulin-mediated glucose disposal in vivo in relation to insulin binding and action in adipocytes in vitro .
6490795	0	glucose	64,71	insulin	8,15	glucose	insulin	MESH:D005947	3630	Chemical	Gene	disposal|compound|START_ENTITY Site|dep|disposal Site|nmod|resistance resistance|compound|END_ENTITY	Site of insulin resistance in type 1 diabetes : insulin-mediated glucose disposal in vivo in relation to insulin binding and action in adipocytes in vitro .
6750084	0	glucose	76,83	insulin	35,42	glucose	insulin	MESH:D005947	105613195	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|Effects Effects|nmod|system system|nmod|END_ENTITY	Effects of the autonomic system on insulin release in response to exogenous glucose in weaned lambs .
6750300	0	glucose	25,32	insulin	14,21	glucose	insulin	MESH:D005947	100009181(Tax:9986)	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|nmod|transport	The effect of insulin on glucose transport in rabbit erythrocytes and reticulocytes .
6750603	0	glucose	53,60	insulin	33,40	glucose	insulin	MESH:D005947	3630	Chemical	Gene	decreased|nmod|START_ENTITY decreased|dobj|response response|compound|END_ENTITY	Insulin resistance and decreased insulin response to glucose in lean type 2 diabetics .
6751902	0	glucose	115,122	insulin	134,141	glucose	insulin	MESH:D005947	3630	Chemical	Gene	controlled|advmod|START_ENTITY system|amod|controlled system|compound|END_ENTITY	The metabolic and hormonal response to acute normoglycaemia in type 1 -LRB- insulin-dependent -RRB- diabetes : studies with a glucose controlled insulin infusion system -LRB- artificial_endocrine_pancreas -RRB- .
6754145	0	glucose	15,22	insulin	41,48	glucose	insulin	MESH:D005947	3630	Chemical	Gene	loading|compound|START_ENTITY loading|nmod|END_ENTITY	Effect of oral glucose loading on plasma insulin , potassium , renin and aldosterone in normal subjects and patients with primary_hyperaldosteronism .
6756622	0	glucose	26,33	insulin	116,123	glucose	insulin	MESH:D005947	3630	Chemical	Gene	turnover|amod|START_ENTITY turnover|nmod|normalization normalization|nmod|END_ENTITY	Exercise in diabetic man : glucose turnover and free insulin responses after glycemic normalization with intravenous insulin .
6756834	0	glucose	46,53	insulin	122,129	glucose	insulin	MESH:D005947	3630	Chemical	Gene	model|nmod|START_ENTITY Use|nmod|model homeostasis|nsubj|Use homeostasis|nmod|assessment assessment|nmod|requirements requirements|nmod|therapies therapies|compound|END_ENTITY	Use of a physiologic pharmacokinetic model of glucose homeostasis for assessment of performance requirements for improved insulin therapies .
6757082	0	glucose	117,124	insulin	83,90	glucose	insulin	MESH:D005947	3630	Chemical	Gene	acetylsalicylic_acid|nmod|START_ENTITY acetylsalicylic_acid|nmod|response response|compound|END_ENTITY	Discrepant effect of the prostaglandin synthesis inhibitor acetylsalicylic_acid on insulin and C-peptide response to glucose in man .
6757268	1	glucose	138,145	insulin	120,127	glucose	insulin	MESH:D005947	3630	Chemical	Gene	increases|dobj|START_ENTITY increases|nsubj|END_ENTITY	Evidence that insulin increases glucose uptake merely by providing additional transport sites .
6759238	0	glucose	38,45	insulin	47,54	glucose	insulin	MESH:D005947	3630	Chemical	Gene	glucagon|compound|START_ENTITY glucagon|dep|END_ENTITY	Effect of exercise -LRB- running -RRB- on serum glucose , insulin , glucagon , and chromium excretion .
6760964	0	glucose	42,49	insulin	22,29	glucose	insulin	MESH:D005947	3630	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	The question of early insulin response to glucose in patients with ischemic_heart_disease : a retrospective study in twins .
6761205	1	glucose	110,117	insulin	66,73	glucose	insulin	MESH:D005947	3630	Chemical	Gene	production|compound|START_ENTITY suppression|nmod|production Mechanisms|appos|suppression Mechanisms|nmod|resistance resistance|compound|END_ENTITY	Mechanisms of insulin resistance , impaired suppression of glucose production , and impaired stimulation of glucose utilization .
6765158	0	glucose	46,53	insulin	18,25	glucose	insulin	MESH:D005947	3630	Chemical	Gene	hormone|compound|START_ENTITY regulation|nmod|hormone Expression|dep|regulation Expression|nmod|gene gene|compound|END_ENTITY	Expression of the insulin gene : regulation by glucose , hydrocortisone and growth hormone in mouse pancreatic islets in organ culture .
6765540	0	glucose	159,166	insulin	87,94	glucose	insulin	MESH:D005947	3630	Chemical	Gene	technique|compound|START_ENTITY concentrations|nmod|technique concentrations|nmod|preparations preparations|compound|END_ENTITY	Insulin concentrations and time-action profiles of three different intermediate-acting insulin preparations in nondiabetic volunteers under glucose-controlled glucose infusion technique .
6765549	2	glucose	285,292	insulin	226,233	glucose	insulin	MESH:D005947	3630	Chemical	Gene	showed|nmod|START_ENTITY showed|nsubj|tests tests|compound|END_ENTITY	Intravenous insulin tolerance tests showed identical effects on plasma glucose when a bolus of 0.1 U/kg was injected .
6771756	0	glucose	46,53	insulin	14,21	glucose	insulin	MESH:D005947	3630	Chemical	Gene	activity|compound|START_ENTITY translocation|nmod|activity causes|dobj|translocation causes|nsubj|END_ENTITY	Evidence that insulin causes translocation of glucose transport activity to the plasma membrane from an intracellular storage site .
6813354	1	glucose	106,113	insulin	129,136	glucose	insulin	MESH:D005947	100009181(Tax:9986)	Chemical	Gene	START_ENTITY|nmod|effect effect|compound|END_ENTITY	Competitive inhibition by glucose and lack of an insulin effect .
683744	0	glucose	56,63	insulin	25,32	glucose	insulin	MESH:D005947	105613195	Chemical	Gene	uptake|compound|START_ENTITY infusions|nmod|uptake infusions|nsubj|Effect Effect|nmod|END_ENTITY	Effect of uterine artery insulin infusions on umbilical glucose uptake in sheep .
690322	0	glucose	23,30	insulin	15,22	glucose	insulin	MESH:D005947	3630	Chemical	Gene	administration|compound|START_ENTITY administration|compound|END_ENTITY	The effects of insulin glucose administration in fulminant_hepatic_failure .
692634	0	glucose	71,78	insulin	12,19	glucose	insulin	MESH:D005947	100009181(Tax:9986)	Chemical	Gene	-RSB-|compound|START_ENTITY Effects|nmod|-RSB- Effects|nmod|END_ENTITY	-LSB- Effects of insulin , glucagon and secretin on intestinal resorption of glucose -RSB- .
6987271	0	glucose	126,133	insulin	26,33	glucose	insulin	MESH:D005947	3630	Chemical	Gene	concentration|compound|START_ENTITY exposure|nmod|concentration pancreas|nmod|exposure END_ENTITY|nmod|pancreas	Sustained oscillations of insulin , glucagon , and somatostatin from the isolated canine pancreas during exposure to a constant glucose concentration .
6987642	0	glucose	56,63	insulin	13,20	glucose	insulin	MESH:D005947	3630	Chemical	Gene	load|compound|START_ENTITY secretion|nmod|load secretion|nsubj|Dynamics Dynamics|nmod|END_ENTITY	-LSB- Dynamics of insulin secretion in response to a peroral glucose load and its diagnostic significance -RSB- .
6988933	0	glucose	31,38	insulin	6,13	glucose	insulin	MESH:D005947	3630	Chemical	Gene	load|compound|START_ENTITY response|nmod|load response|compound|END_ENTITY	Serum insulin response to oral glucose load during a dietary intervention trial in healthy coronary high risk men : the Oslo study .
6990147	0	glucose	66,73	insulin	114,121	glucose	insulin	MESH:D005947	3630	Chemical	Gene	polypeptide|nmod|START_ENTITY Interaction|nmod|polypeptide Interaction|acl|effect effect|dobj|secretion secretion|nmod|END_ENTITY	Interaction of a newly isolated intestinal polypeptide -LRB- PHI -RRB- with glucose and arginine to effect the secretion of insulin and glucagon .
6991326	0	glucose	47,54	insulin	15,22	glucose	insulin	MESH:D005947	3630	Chemical	Gene	solutions|nmod|START_ENTITY solutions|compound|END_ENTITY	Nonaggregating insulin solutions for long-term glucose control in experimental and human diabetes .
6992089	0	glucose	54,61	insulin	12,19	glucose	insulin	MESH:D005947	3630	Chemical	Gene	fetal|nmod|START_ENTITY fetal|dobj|secretion secretion|compound|END_ENTITY	Human fetal insulin secretion in response to maternal glucose and leucine administration .
6992922	0	glucose	62,69	insulin	24,31	glucose	insulin	MESH:D005947	3630	Chemical	Gene	concentration|compound|START_ENTITY infusion|nmod|concentration infusion|compound|END_ENTITY	Subcutaneous continuous insulin infusion and control of blood glucose concentration in diabetics in third trimester of pregnancy .
6993141	0	glucose	94,101	insulin	51,58	glucose	insulin	MESH:D005947	3630	Chemical	Gene	controller|compound|START_ENTITY Considerations|nmod|controller Considerations|nmod|programming programming|nmod|device device|compound|END_ENTITY	Considerations for the programming of an open-loop insulin infusion device from the biostator glucose controller .
6993262	0	glucose	24,31	insulin	4,11	glucose	insulin	MESH:D005947	3630	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	The insulin response to glucose infusion_in_gestational_diabetes .
6993263	0	glucose	24,31	insulin	4,11	glucose	insulin	MESH:D005947	3630	Chemical	Gene	infusion|compound|START_ENTITY response|nmod|infusion response|compound|END_ENTITY	The insulin response to glucose infusion in normal human pregnancy .
6993538	0	glucose	17,24	insulin	59,66	glucose	insulin	MESH:D005947	3630	Chemical	Gene	utilization|compound|START_ENTITY age|nmod|utilization Effect|nmod|age Effect|nmod|END_ENTITY	Effect of age on glucose utilization and responsiveness to insulin in forearm muscle .
6998703	0	glucose	24,31	insulin	33,40	glucose	insulin	MESH:D005947	3630	Chemical	Gene	gastrin|compound|START_ENTITY gastrin|dep|END_ENTITY	Fasting blood values of glucose , insulin , glucagon , gastrin following highly_selective_vagotomy in duodenal ulcer patients .
7002673	0	glucose	52,59	insulin	103,110	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	sensitivity|nmod|START_ENTITY estimation|nmod|sensitivity estimation|dep|model model|nmod|kinetics kinetics|compound|END_ENTITY	Quantitative estimation of beta cell sensitivity to glucose in the intact organism : a minimal model of insulin kinetics in the dog .
700280	0	glucose	58,65	insulin	89,96	glucose	insulin	MESH:D005947	3630	Chemical	Gene	Characterisation|nmod|START_ENTITY Characterisation|nmod|rate rate|compound|END_ENTITY	Characterisation of the effect of intravenous infusion of glucose and tolbutamide on the insulin delivery rate in man .
7005257	0	glucose	15,22	insulin	53,60	glucose	insulin	MESH:D005947	3630	Chemical	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Suppression of glucose production and stimulation of insulin secretion by physiological concentrations of ketone bodies in man .
7009288	0	glucose	53,60	insulin	10,17	glucose	insulin	MESH:D005947	101794427	Chemical	Gene	metabolism|compound|START_ENTITY mediated|nmod|metabolism mediated|nsubj|Effect Effect|nmod|END_ENTITY	Effect of insulin on glucagon secretion mediated via glucose metabolism of pancreatic A cells in ducks .
7009366	0	glucose	27,34	insulin	7,14	glucose	insulin	MESH:D005947	3630	Chemical	Gene	infusion|compound|START_ENTITY response|nmod|infusion response|compound|END_ENTITY	Plasma insulin response to glucose infusion in obese_non-diabetic_and_diabetic_subjects .
7011013	7	glucose	1068,1075	insulin	1047,1054	glucose	insulin	MESH:D005947	3630	Chemical	Gene	insulin|compound|START_ENTITY secretion|nmod|insulin secretion|compound|END_ENTITY	The model shows why this increase in plasma glucose occurs and the importance of this hyperglycemia to the restoration of insulin responses to nonglucose secretagogues , second-phase insulin secretion to glucose and basal insulin .
7011721	0	glucose	60,67	insulin	19,26	glucose	insulin	MESH:D005947	3630	Chemical	Gene	men|nmod|START_ENTITY effect|nmod|men END_ENTITY|dep|effect	Biosynthetic human insulin : effect in healthy men on plasma glucose and non-esterified fatty_acids in comparison with highly purified pork insulin .
7011725	0	glucose	143,150	insulin	162,169	glucose	insulin	MESH:D005947	3630	Chemical	Gene	system|compound|START_ENTITY system|compound|END_ENTITY	Comparison of the biologic activity of biosynthetic human insulin and natural pork insulin in juvenile-onset diabetic subjects assessed by the glucose controlled insulin infusion system .
7011725	0	glucose	143,150	insulin	58,65	glucose	insulin	MESH:D005947	3630	Chemical	Gene	system|compound|START_ENTITY assessed|nmod|system assessed|nsubj|Comparison Comparison|nmod|activity activity|nmod|END_ENTITY	Comparison of the biologic activity of biosynthetic human insulin and natural pork insulin in juvenile-onset diabetic subjects assessed by the glucose controlled insulin infusion system .
7011749	0	glucose	74,81	insulin	29,36	glucose	insulin	MESH:D005947	3630	Chemical	Gene	monitor|dobj|START_ENTITY patients|acl:relcl|monitor dosage|nmod|patients dosage|nsubj|Algorithms Algorithms|nmod|adjustment adjustment|nmod|END_ENTITY	Algorithms for adjustment of insulin dosage by patients who monitor blood glucose .
7014196	0	glucose	43,50	insulin	14,21	glucose	insulin	MESH:D005947	280829(Tax:9913)	Chemical	Gene	metabolism|nmod|START_ENTITY effect|nmod|metabolism effect|nmod|END_ENTITY	The effect of insulin on net metabolism of glucose and amino_acids by the bovine mammary gland .
7018254	0	glucose	86,93	insulin	45,52	glucose	insulin	MESH:D005947	3630	Chemical	Gene	characteristics|nmod|START_ENTITY characteristics|nmod|effects effects|nmod|END_ENTITY	Dose-response characteristics for effects of insulin on production and utilization of glucose in man .
7020889	0	glucose	12,19	insulin	63,70	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	test|compound|START_ENTITY test|dep|response response|compound|END_ENTITY	Intravenous glucose tolerance test during anaesthesia in dogs : insulin response and glucose clearance .
7021126	0	glucose	17,24	insulin	42,49	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY behavior|nmod|tolerance -LSB-|dobj|behavior -RSB-|advcl|-LSB- -RSB-|nsubj|END_ENTITY	-LSB- The behavior of glucose tolerance , serum insulin and C-peptide in acute_viral_hepatitis -RSB- .
7021276	0	glucose	67,74	insulin	38,45	glucose	insulin	MESH:D005947	3630	Chemical	Gene	infusion|nmod|START_ENTITY infusion|compound|END_ENTITY	The effects of a low-dose intravenous insulin infusion upon plasma glucose and non-esterified fatty_acid levels in very_obese_and_non-obese human subjects .
7030723	1	glucose	203,210	insulin	178,185	glucose	insulin	MESH:D005947	3630	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Insulin binding to circulating erythrocytes was studied in 32 maturity onset-type diabetic patients with varying degrees of insulin response to oral glucose .
7032544	0	glucose	84,91	insulin	27,34	glucose	insulin	MESH:D005947	3630	Chemical	Gene	load|compound|START_ENTITY Correlation|nmod|load Correlation|nmod|response response|compound|END_ENTITY	-LSB- Correlation between blood insulin response and blood potassium changes during oral glucose load -LRB- preliminary note -RRB- -RSB- .
7033265	0	glucose	106,113	insulin	158,165	glucose	insulin	MESH:D005947	3630	Chemical	Gene	utilization|compound|START_ENTITY suppression|nmod|utilization suppression|nmod|detect detect|nmod|action action|compound|END_ENTITY	Cortisol-induced insulin resistance in man : impaired suppression of glucose production and stimulation of glucose utilization due to a postreceptor detect of insulin action .
7033265	0	glucose	106,113	insulin	17,24	glucose	insulin	MESH:D005947	3630	Chemical	Gene	utilization|compound|START_ENTITY suppression|nmod|utilization resistance|dep|suppression resistance|compound|END_ENTITY	Cortisol-induced insulin resistance in man : impaired suppression of glucose production and stimulation of glucose utilization due to a postreceptor detect of insulin action .
7033265	0	glucose	68,75	insulin	158,165	glucose	insulin	MESH:D005947	3630	Chemical	Gene	production|compound|START_ENTITY suppression|nmod|production suppression|nmod|detect detect|nmod|action action|compound|END_ENTITY	Cortisol-induced insulin resistance in man : impaired suppression of glucose production and stimulation of glucose utilization due to a postreceptor detect of insulin action .
7033265	0	glucose	68,75	insulin	17,24	glucose	insulin	MESH:D005947	3630	Chemical	Gene	production|compound|START_ENTITY suppression|nmod|production resistance|dep|suppression resistance|compound|END_ENTITY	Cortisol-induced insulin resistance in man : impaired suppression of glucose production and stimulation of glucose utilization due to a postreceptor detect of insulin action .
7033268	0	glucose	48,55	insulin	23,30	glucose	insulin	MESH:D005947	3630	Chemical	Gene	levels|compound|START_ENTITY enhancement|dep|levels enhancement|nmod|action action|compound|END_ENTITY	Glucose enhancement of insulin action : elevated glucose levels increase insulin stimulation of 2-deoxyglucose uptake in cultured human fibroblasts .
7033268	0	glucose	48,55	insulin	72,79	glucose	insulin	MESH:D005947	3630	Chemical	Gene	levels|compound|START_ENTITY levels|dep|stimulation stimulation|compound|END_ENTITY	Glucose enhancement of insulin action : elevated glucose levels increase insulin stimulation of 2-deoxyglucose uptake in cultured human fibroblasts .
7033272	0	glucose	95,102	insulin	15,22	glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|nmod|START_ENTITY Improvement|nmod|control Improvement|nmod|secretion secretion|compound|END_ENTITY	Improvement of insulin secretion but not insulin resistance after short term control of plasma glucose in obese_type_II_diabetics .
7034539	0	glucose	60,67	insulin	25,32	glucose	insulin	MESH:D005947	105613195	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of maternal serum insulin on umbilical extraction of glucose and lactate in fed and fasted sheep .
7035020	0	glucose	26,33	insulin	11,18	glucose	insulin	MESH:D005947	3630	Chemical	Gene	system|compound|START_ENTITY Action|nmod|system Action|nmod|END_ENTITY	-LSB- Action of insulin on the glucose transport system -- on the `` translocation hypothesis '' -LRB- author 's transl -RRB- -RSB- .
7035023	0	glucose	66,73	insulin	15,22	glucose	insulin	MESH:D005947	3630	Chemical	Gene	hypothalamus|nmod|START_ENTITY -LSB-|nmod|hypothalamus -LSB-|dobj|effect effect|nmod|microinjection microinjection|compound|END_ENTITY	-LSB- The effect of insulin microinjection into hypothalamus on plasma glucose -LRB- author 's transl -RRB- -RSB- .
7035027	0	glucose	32,39	insulin	14,21	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY action|nmod|metabolism action|compound|END_ENTITY	-LSB- Mechanism of insulin action on glucose and lipid metabolism in hepatocytes -LRB- author 's transl -RRB- -RSB- .
7037507	0	glucose	115,122	insulin	66,73	glucose	insulin	MESH:D005947	3630	Chemical	Gene	technique|compound|START_ENTITY comparison|nmod|technique comparison|nmod|activity activity|nmod|END_ENTITY	A comparison of the activity and disposal of semi-synthetic human insulin and porcine insulin in normal man by the glucose clamp technique .
7038916	0	glucose	44,51	insulin	4,11	glucose	insulin	MESH:D005947	3630	Chemical	Gene	load|compound|START_ENTITY response|nmod|load response|compound|END_ENTITY	The insulin and glucose response to an oral glucose load in non-insulin-dependent_diabetes in the young .
7040143	0	glucose	119,126	insulin	38,45	glucose	insulin	MESH:D005947	3630	Chemical	Gene	variations|nmod|START_ENTITY infusion|nmod|variations infusion|compound|END_ENTITY	The effect of continuous subcutaneous insulin infusion and conventional insulin regimes on 24-hour variations of blood glucose and intermediary metabolites in the third trimester of diabetic pregnancy .
7042656	0	glucose	99,106	insulin	44,51	glucose	insulin	MESH:D005947	3630	Chemical	Gene	fasting|nmod|START_ENTITY fasting|dobj|concentration concentration|compound|END_ENTITY	Relation of habitual diet to fasting plasma insulin concentration and the insulin response to oral glucose .
7043172	0	glucose	111,118	insulin	21,28	glucose	insulin	MESH:D005947	3630	Chemical	Gene	transport|compound|START_ENTITY stimulated|dobj|transport Similarities|acl|stimulated Similarities|nmod|END_ENTITY	Similarities between insulin , hydrogen_peroxide , concanavalin A , and anti-insulin_receptor antibody stimulated glucose transport : increase in the number of transport sites .
7043177	0	glucose	21,28	insulin	88,95	glucose	insulin	MESH:D005947	3630	Chemical	Gene	Variations|nmod|START_ENTITY Variations|nmod|response response|nmod|END_ENTITY	Variations in plasma glucose , insulin , growth_hormone and catecholamines in response to insulin in trained and non-trained subjects .
7045153	0	glucose	147,154	insulin	94,101	glucose	insulin	MESH:D005947	3630	Chemical	Gene	increasing|nmod|START_ENTITY augments|advcl|increasing augments|dobj|secretion secretion|compound|END_ENTITY	Chronic chlorpropamide therapy of noninsulin-dependent diabetes augments basal and stimulated insulin secretion by increasing islet sensitivity to glucose .
7050125	0	glucose	106,113	insulin	88,95	glucose	insulin	MESH:D005947	3630	Chemical	Gene	transport|compound|START_ENTITY action|nmod|transport action|compound|END_ENTITY	Evidence that translocation of the glucose transport activity is the major mechanism of insulin action on glucose transport in fat cells .
7050125	0	glucose	35,42	insulin	88,95	glucose	insulin	MESH:D005947	3630	Chemical	Gene	activity|compound|START_ENTITY translocation|nmod|activity Evidence|acl:relcl|translocation mechanism|nsubj|Evidence mechanism|nmod|action action|compound|END_ENTITY	Evidence that translocation of the glucose transport activity is the major mechanism of insulin action on glucose transport in fat cells .
7050220	0	glucose	17,24	insulin	36,43	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY tolerance|appos|secretion secretion|compound|END_ENTITY	Effect of age on glucose tolerance , insulin secretion , and in vivo insulin action .
7050229	0	glucose	85,92	insulin	22,29	glucose	insulin	MESH:D005947	3630	Chemical	Gene	administration|nmod|START_ENTITY END_ENTITY|nmod|administration	Blood glucose , plasma insulin and glucagon response to intravenous administration of glucose in premature infants during the first week of life .
7351877	0	glucose	14,21	insulin	84,91	glucose	insulin	MESH:D005947	3630	Chemical	Gene	sorbitol|compound|START_ENTITY Comparison|nmod|sorbitol Comparison|nmod|humans humans|nmod|suppression suppression|compound|END_ENTITY	Comparison of glucose , fructose , sorbitol , and xylitol utilization in humans during insulin suppression .
7356691	0	glucose	10,17	insulin	45,52	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|independent independent|nmod|changes changes|nmod|secretion secretion|compound|END_ENTITY	Effect of glucose , independent of changes in insulin and glucagon secretion , on alanine metabolism in the conscious dog .
736715	0	glucose	41,48	insulin	60,67	glucose	insulin	MESH:D005947	280829(Tax:9913)	Chemical	Gene	fatty_acids|compound|START_ENTITY fatty_acids|dep|END_ENTITY	-LSB- Behavior of various blood constituents -LRB- glucose , fructose , insulin , lactate , pyruvate , free fatty_acids , inorganic phosphate -RRB- and half-life of monosaccharides in the plasma after i.v. infusion of glucose , _ fructose , _ galactose and invert sugar solutions in ruminants .
736716	0	glucose	197,204	insulin	60,67	glucose	insulin	MESH:D005947	280829(Tax:9913)	Chemical	Gene	solutions|compound|START_ENTITY Behavior|nmod|solutions Behavior|nmod|constituents constituents|dep|fatty_acids fatty_acids|dep|END_ENTITY	-LSB- Behavior of various blood constituents -LRB- glucose , fructose , insulin , lactate , pyruvate , free fatty_acids , inorganic phosphate -RRB- and half-life of monosaccharides in the plasma after i.v. infusion of glucose , fructose , galactose and invert sugar solutions in ruminants .
736716	0	glucose	41,48	insulin	60,67	glucose	insulin	MESH:D005947	280829(Tax:9913)	Chemical	Gene	fatty_acids|compound|START_ENTITY fatty_acids|dep|END_ENTITY	-LSB- Behavior of various blood constituents -LRB- glucose , fructose , insulin , lactate , pyruvate , free fatty_acids , inorganic phosphate -RRB- and half-life of monosaccharides in the plasma after i.v. infusion of glucose , fructose , galactose and invert sugar solutions in ruminants .
736717	0	glucose	196,203	insulin	60,67	glucose	insulin	MESH:D005947	105613195	Chemical	Gene	solutions|compound|START_ENTITY infusion|nmod|solutions Behavior|nmod|infusion Behavior|nmod|constituents constituents|dep|fatty_acids fatty_acids|dep|END_ENTITY	-LSB- Behavior of various blood constituents -LRB- glucose , fructose , insulin , lactate , pyruvate , free fatty_acids , inorganic phosphate -RRB- and the half-life of monosaccharides in plasma after i.v infusion of glucose , fructose , galactose and invert sugar solutions in ruminants .
736717	0	glucose	41,48	insulin	60,67	glucose	insulin	MESH:D005947	105613195	Chemical	Gene	fatty_acids|compound|START_ENTITY fatty_acids|dep|END_ENTITY	-LSB- Behavior of various blood constituents -LRB- glucose , fructose , insulin , lactate , pyruvate , free fatty_acids , inorganic phosphate -RRB- and the half-life of monosaccharides in plasma after i.v infusion of glucose , fructose , galactose and invert sugar solutions in ruminants .
7373008	0	glucose	38,45	insulin	12,19	glucose	insulin	MESH:D005947	3630	Chemical	Gene	Response|nmod|START_ENTITY Response|nmod|receptors receptors|compound|END_ENTITY	Response of insulin receptors to oral glucose in normal subjects .
7491105	0	glucose	94,101	insulin	17,24	glucose	insulin	MESH:D005947	3630	Chemical	Gene	concentration|compound|START_ENTITY cells|nmod|concentration transcription|nmod|cells transcription|compound|END_ENTITY	The reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to high glucose concentration is associated with the loss of RIPE3b1 and STF-1 transcription factor expression .
7524064	0	glucose	92,99	insulin	58,65	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	production|compound|START_ENTITY secretion|nmod|production secretion|nsubj|effects effects|nmod|suppression suppression|nmod|END_ENTITY	Differential effects of a graded selective suppression of insulin secretion with galanin on glucose production and removal in dogs .
7565999	0	glucose	38,45	insulin	111,118	glucose	insulin	MESH:D005947	3630	Chemical	Gene	monitoring|compound|START_ENTITY Postprandial|nmod|monitoring mellitus|nsubj|Postprandial mellitus|xcomp|requiring requiring|dobj|therapy therapy|compound|END_ENTITY	Postprandial versus preprandial blood glucose monitoring in women with gestational_diabetes mellitus requiring insulin therapy .
7568086	0	glucose	104,111	insulin	13,20	glucose	insulin	MESH:D005947	3630	Chemical	Gene	concentration|compound|START_ENTITY cells|nmod|concentration transcription|nmod|cells transcription|compound|END_ENTITY	Reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to a supraphysiologic glucose concentration is associated with loss of STF-1 transcription factor expression .
7572943	0	glucose	95,102	insulin	22,29	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY sampled|dobj|tolerance derived|advcl|sampled measures|acl|derived measures|compound|END_ENTITY	Exploration of simple insulin sensitivity measures derived from frequently sampled intravenous glucose tolerance -LRB- FSIGT -RRB- tests .
759254	0	glucose	100,107	insulin	44,51	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	infusions|compound|START_ENTITY given|dobj|infusions given|nsubj|regulation regulation|acl|using using|dobj|system system|compound|END_ENTITY	Blood glucose regulation using an open-loop insulin delivery system in pancreatectomized dogs given glucose infusions .
759254	0	glucose	6,13	insulin	44,51	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	regulation|compound|START_ENTITY regulation|acl|using using|dobj|system system|compound|END_ENTITY	Blood glucose regulation using an open-loop insulin delivery system in pancreatectomized dogs given glucose infusions .
7601726	0	glucose	60,67	insulin	69,76	glucose	insulin	MESH:D005947	100060077(Tax:9796)	Chemical	Gene	restriction|dep|START_ENTITY END_ENTITY|nsubj|restriction	Dietary protein and -LRB- or -RRB- energy restriction in mares : plasma glucose , insulin , nonesterified fatty_acid , and urea_nitrogen responses to feeding , glucose , and epinephrine .
7611377	0	glucose	19,26	insulin	85,92	glucose	insulin	MESH:D005947	3630	Chemical	Gene	uptake|compound|START_ENTITY enhanced|nsubjpass|uptake enhanced|nmod|responders responders|compound|END_ENTITY	Insulin-stimulated glucose uptake is enhanced in sedentary and endurance-trained low insulin responders .
7612911	0	glucose	47,54	insulin	26,33	glucose	insulin	MESH:D005947	3630	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|inhibition inhibition|nmod|END_ENTITY	Paradoxical inhibition of insulin secretion by glucose in non-insulin-dependent diabetic patients .
7629403	0	glucose	75,82	insulin	7,14	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY END_ENTITY|nmod|tolerance	Plasma insulin and blood pressure in normotensive Japanese men with normal glucose tolerance .
7637151	0	glucose	73,80	insulin	44,51	glucose	insulin	MESH:D005947	3630	Chemical	Gene	infusion|compound|START_ENTITY immunoreactive|nmod|infusion immunoreactive|dobj|concentrations concentrations|compound|END_ENTITY	-LSB- Portal and peripheral blood immunoreactive insulin concentrations after glucose infusion during gastrectomy -RSB- .
7657052	0	glucose	23,30	insulin	71,78	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY increases|dobj|tolerance increases|nmod|independent independent|nmod|secretion secretion|compound|END_ENTITY	Sham feeding increases glucose tolerance by a mechanism independent of insulin secretion in normal subjects .
7662232	0	glucose	68,75	insulin	45,52	glucose	insulin	MESH:D005947	3630	Chemical	Gene	load|compound|START_ENTITY improves|nmod|load improves|dobj|responses responses|compound|END_ENTITY	Doxazosin lowers blood pressure and improves insulin responses to a glucose load with no changes in tyrosine kinase activity or insulin binding .
7706450	0	glucose	8,15	insulin	58,65	glucose	insulin	MESH:D005947	3630	Chemical	Gene	profiles|compound|START_ENTITY profiles|nmod|infusion infusion|compound|END_ENTITY	24-hour glucose profiles during continuous or oscillatory insulin infusion .
7713278	0	glucose	21,28	insulin	93,100	glucose	insulin	MESH:D005947	3630	Chemical	Gene	levels|compound|START_ENTITY Variability|nmod|levels Variability|nmod|patients patients|nmod|type_1_diabetes_mellitus type_1_diabetes_mellitus|nmod|regimens regimens|compound|END_ENTITY	Variability of blood glucose levels in patients with type_1_diabetes_mellitus on intensified insulin regimens .
7730693	0	glucose	42,49	insulin	10,17	glucose	insulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY evaluated|nmod|test resistance|acl|evaluated resistance|compound|END_ENTITY	-LSB- Study on insulin resistance evaluated by glucose tolerance test in obese pregnant women -RSB- .
7758074	0	glucose	42,49	insulin	61,68	glucose	insulin	MESH:D005947	3630	Chemical	Gene	secretion|compound|START_ENTITY secretion|dep|END_ENTITY	-LSB- Risk of diabetes_mellitus , variations in glucose tolerance , insulin secretion and lipid parameters in offspring of diabetic mothers -RSB- .
7762630	0	glucose	22,29	insulin	100,107	glucose	insulin	MESH:D005947	3630	Chemical	Gene	disposal|compound|START_ENTITY Stimulation|nmod|disposal function|nsubj|Stimulation function|nmod|level level|compound|END_ENTITY	Stimulation of muscle glucose disposal by insulin in humans is a function of the preexisting plasma insulin level .
7762630	0	glucose	22,29	insulin	42,49	glucose	insulin	MESH:D005947	3630	Chemical	Gene	disposal|compound|START_ENTITY disposal|nmod|END_ENTITY	Stimulation of muscle glucose disposal by insulin in humans is a function of the preexisting plasma insulin level .
7780493	0	glucose	94,101	insulin	13,20	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY persons|nmod|tolerance associated|nmod|persons levels|acl|associated levels|compound|END_ENTITY	High fasting insulin levels associated with lower rates of weight_gain in persons with normal glucose tolerance : the San Luis Valley Diabetes Study .
7789626	0	glucose	130,137	insulin	27,34	glucose	insulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY sampled|dobj|test sampled|nsubj|Comparison Comparison|nmod|estimates estimates|nmod|sensitivity sensitivity|compound|END_ENTITY	Comparison of estimates of insulin sensitivity from minimal model analysis of the insulin-modified frequently sampled intravenous glucose tolerance test and the isoglycemic_hyperinsulinemic_clamp in subjects with NIDDM .
7805925	0	glucose	54,61	insulin	22,29	glucose	insulin	MESH:D005947	3630	Chemical	Gene	differences|nmod|START_ENTITY differences|nmod|response response|compound|END_ENTITY	Ethnic differences in insulin and glucose response to glucose between white and Indian women with polycystic_ovary_syndrome .
7806018	0	glucose	59,66	insulin	104,111	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY subjects|nmod|tolerance Hypertriglyceridaemia|nmod|subjects Hypertriglyceridaemia|dep|contributions contributions|nmod|secretion secretion|compound|END_ENTITY	Hypertriglyceridaemia in subjects with normal and abnormal glucose tolerance : relative contributions of insulin secretion , insulin resistance and suppression of plasma non-esterified fatty_acids .
7806018	0	glucose	59,66	insulin	123,130	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY subjects|nmod|tolerance Hypertriglyceridaemia|nmod|subjects Hypertriglyceridaemia|dep|contributions contributions|nmod|secretion secretion|appos|resistance resistance|compound|END_ENTITY	Hypertriglyceridaemia in subjects with normal and abnormal glucose tolerance : relative contributions of insulin secretion , insulin resistance and suppression of plasma non-esterified fatty_acids .
781574	0	glucose	55,62	insulin	7,14	glucose	insulin	MESH:D005947	3630	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Plasma insulin response following oral and intravenous glucose in pregnant diabetic women .
7854164	0	glucose	54,61	insulin	14,21	glucose	insulin	MESH:D005947	3630	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of basal insulin in maintenance of intracellular glucose metabolic pathways in non-insulin-dependent_diabetes_mellitus .
786513	0	glucose	67,74	insulin	47,54	glucose	insulin	MESH:D005947	3630	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Significance of genetic factors for the plasma insulin response to glucose in healthy subjects .
786634	6	glucose	734,741	insulin	716,723	glucose	insulin	MESH:D005947	3630	Chemical	Gene	uptake|compound|START_ENTITY mimic|nmod|uptake mimic|dobj|effect effect|compound|END_ENTITY	Moreover , the ionophore A_23187 could be shown to mimic the insulin effect on glucose uptake .
7885275	0	glucose	39,46	insulin	15,22	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY sensitivity|nmod|metabolism sensitivity|compound|END_ENTITY	Improvement of insulin sensitivity for glucose metabolism with the long-acting Ca-channel blocker amlodipine in essential hypertensive subjects .
789145	0	glucose	92,99	insulin	24,31	glucose	insulin	MESH:D005947	3630	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|inhibition inhibition|nmod|END_ENTITY	Feed-back inhibition of insulin secretion in subjects with high and low insulin response to glucose .
789145	0	glucose	92,99	insulin	72,79	glucose	insulin	MESH:D005947	3630	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nmod|response response|compound|END_ENTITY	Feed-back inhibition of insulin secretion in subjects with high and low insulin response to glucose .
7901997	0	glucose	16,23	insulin	93,100	glucose	insulin	MESH:D005947	3630	Chemical	Gene	concentration|compound|START_ENTITY decreases|nsubj|concentration decreases|dobj|independent independent|nmod|END_ENTITY	Increased fetal glucose concentration decreases ovine fetal leucine oxidation independent of insulin .
7903182	0	glucose	63,70	insulin	29,36	glucose	insulin	MESH:D005947	3630	Chemical	Gene	uptake|compound|START_ENTITY uptake|compound|END_ENTITY	Effects of acute exercise on insulin and non-insulin-dependent glucose uptake in normal and moderately obese women .
7907998	0	glucose	50,57	insulin	20,27	glucose	insulin	MESH:D005947	3630	Chemical	Gene	transcription|nmod|START_ENTITY transcription|nsubj|Regulation Regulation|nmod|gene gene|compound|END_ENTITY	Regulation of human insulin gene transcription by glucose , epinephrine , and somatostatin .
7924163	0	glucose	90,97	insulin	70,77	glucose	insulin	MESH:D005947	3630	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Physical fitness_and_insulin_sensitivity in human subjects with a low insulin response to glucose .
7924163	7	glucose	1565,1572	insulin	1491,1498	glucose	insulin	MESH:D005947	3630	Chemical	Gene	exhibited|nmod|START_ENTITY exhibited|nsubj|responders responders|compound|END_ENTITY	In conclusion , we demonstrate that low insulin responders exhibited decreased insulin and C-peptide responses to glucose , despite normal insulin sensitivity and exercise capacity .
7934624	0	glucose	93,100	insulin	24,31	glucose	insulin	MESH:D005947	3630	Chemical	Gene	uptake|compound|START_ENTITY increases|nmod|uptake induced|dobj|increases induced|nsubj|mechanism mechanism|nmod|induced induced|compound|END_ENTITY	Different mechanism for insulin induced and contraction induced increases in skeletal muscle glucose uptake .
794823	0	glucose	55,62	insulin	22,29	glucose	insulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY test|dep|-LSB- -LSB-|dobj|method method|acl|studying studying|dobj|secretion secretion|compound|END_ENTITY	-LSB- A method of studying insulin secretion in humans : the glucose stimulation test , followed by tolbutamide -RSB- .
795641	0	glucose	46,53	insulin	17,24	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	administration|compound|START_ENTITY secretion|nmod|administration secretion|nsubj|mechanism mechanism|nmod|END_ENTITY	The mechanism of insulin secretion after oral glucose administration .
795641	2	glucose	117,124	insulin	93,100	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	loading|compound|START_ENTITY excretion|nmod|loading excretion|nsubj|END_ENTITY	Pancreatic juice insulin excretion after glucose loading and meal ingestion in normal and vagotomized dogs .
8027230	0	glucose	111,118	insulin	86,93	glucose	insulin	MESH:D005947	3630	Chemical	Gene	showing|nmod|START_ENTITY showing|dobj|response response|compound|END_ENTITY	Insulin response to intravenous glucose in patients with anorexia_nervosa showing low insulin response to oral glucose .
8027230	0	glucose	32,39	insulin	86,93	glucose	insulin	MESH:D005947	3630	Chemical	Gene	response|nmod|START_ENTITY response|acl|showing showing|dobj|response response|compound|END_ENTITY	Insulin response to intravenous glucose in patients with anorexia_nervosa showing low insulin response to oral glucose .
8033528	0	glucose	100,107	insulin	153,160	glucose	insulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY test|nmod|measurements measurements|nmod|resistance resistance|compound|END_ENTITY	Understanding oral glucose tolerance : comparison of glucose or insulin measurements during the oral glucose tolerance test with specific measurements of insulin resistance and insulin secretion .
8033528	0	glucose	19,26	insulin	153,160	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY tolerance|dep|comparison comparison|nmod|measurements measurements|nmod|test test|nmod|measurements measurements|nmod|resistance resistance|compound|END_ENTITY	Understanding oral glucose tolerance : comparison of glucose or insulin measurements during the oral glucose tolerance test with specific measurements of insulin resistance and insulin secretion .
8033528	0	glucose	52,59	insulin	153,160	glucose	insulin	MESH:D005947	3630	Chemical	Gene	measurements|compound|START_ENTITY measurements|nmod|test test|nmod|measurements measurements|nmod|resistance resistance|compound|END_ENTITY	Understanding oral glucose tolerance : comparison of glucose or insulin measurements during the oral glucose tolerance test with specific measurements of insulin resistance and insulin secretion .
8043893	0	glucose	78,85	insulin	25,32	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY determinants|nmod|tolerance interplay|nmod|determinants interplay|nmod|secretion secretion|compound|END_ENTITY	On the interplay between insulin secretion and sensitivity as determinants of glucose tolerance .
8048939	0	glucose	5,12	insulin	45,52	glucose	insulin	MESH:D005947	3630	Chemical	Gene	decrease|nsubj|START_ENTITY decrease|dobj|mRNA mRNA|compound|END_ENTITY	High glucose and insulin decrease fetal lung insulin receptor mRNA and tyrosine kinase activity in vitro .
8061346	0	glucose	35,42	insulin	93,100	glucose	insulin	MESH:D005947	3630	Chemical	Gene	fatty_acid|compound|START_ENTITY autonomic_neuropathy|nmod|fatty_acid Effects|nmod|autonomic_neuropathy metabolism|nsubj|Effects metabolism|dobj|withdrawal withdrawal|compound|END_ENTITY	Effects of autonomic_neuropathy on glucose , fatty_acid , and ketone body metabolism following insulin withdrawal in patients with insulin-dependent_diabetes .
8070607	0	glucose	16,23	insulin	86,93	glucose	insulin	MESH:D005947	3630	Chemical	Gene	toxicity|compound|START_ENTITY toxicity|dep|message message|nmod|gene gene|compound|END_ENTITY	Differentiating glucose toxicity from glucose desensitization : a new message from the insulin gene .
8070607	0	glucose	38,45	insulin	86,93	glucose	insulin	MESH:D005947	3630	Chemical	Gene	desensitization|compound|START_ENTITY toxicity|nmod|desensitization toxicity|dep|message message|nmod|gene gene|compound|END_ENTITY	Differentiating glucose toxicity from glucose desensitization : a new message from the insulin gene .
8111717	0	glucose	56,63	insulin	19,26	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|nsubj|START_ENTITY metabolism|nmod|effects effects|nmod|END_ENTITY	In vivo effects of insulin on tumor and skeletal muscle glucose metabolism in patients with lymphoma .
8116725	2	glucose	391,398	insulin	357,364	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	testing|compound|START_ENTITY matched|nmod|testing matched|nmod|resistance resistance|compound|END_ENTITY	STUDY DESIGN : Abdominal adipose tissue was obtained from eight lean pregnant and nine control subjects , matched for insulin resistance by intravenous glucose tolerance testing .
8121304	0	glucose	95,102	insulin	24,31	glucose	insulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY modulating|nmod|test effects|acl|modulating effects|nmod|END_ENTITY	The opposing effects of insulin and hyperglycemia in modulating amino_acid metabolism during a glucose tolerance test in lean and obese subjects .
8128180	10	glucose	1603,1610	insulin	1684,1691	glucose	insulin	MESH:D005947	3630	Chemical	Gene	transport|compound|START_ENTITY capacity|nmod|transport had|dobj|capacity had|nmod|irrespective irrespective|nmod|degree degree|nmod|resistance resistance|compound|END_ENTITY	In conclusion , the present group of patients , with liver_cirrhosis on an alcoholic basis , had a normal insulin-stimulated capacity for glucose transport at the cellular level irrespective of the degree of whole-body insulin resistance .
8136423	0	glucose	60,67	insulin	8,15	glucose	insulin	MESH:D005947	3630	Chemical	Gene	-RSB-|compound|START_ENTITY changes|nmod|-RSB- changes|nsubj|END_ENTITY	-LSB- Plasma insulin changes in obesity with or without abnormal glucose tolerance -RSB- .
8143760	0	glucose	24,31	insulin	13,20	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	Influence of insulin on glucose metabolism and lipolysis in adipose tissue in situ in patients with liver_cirrhosis .
8144824	0	glucose	78,85	insulin	49,56	glucose	insulin	MESH:D005947	3630	Chemical	Gene	challenge|compound|START_ENTITY lowers|nmod|challenge lowers|dobj|responses responses|compound|END_ENTITY	Seven consecutive days of exercise lowers plasma insulin responses to an oral glucose challenge in sedentary elderly .
8156098	0	glucose	88,95	insulin	14,21	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY degrees|nmod|tolerance patients|nmod|degrees sensitivity|nmod|patients sensitivity|compound|END_ENTITY	No changes of insulin sensitivity in cystic_fibrosis patients with different degrees of glucose tolerance : an epidemiological and longitudinal study .
8172873	0	glucose	21,28	insulin	30,37	glucose	insulin	MESH:D005947	3630	Chemical	Gene	fatty_acid|compound|START_ENTITY fatty_acid|dep|END_ENTITY	Effect of alcohol on glucose , insulin , free fatty_acid and triacylglycerol responses to a light meal in non-insulin-dependent diabetic subjects .
8175959	0	glucose	128,135	insulin	15,22	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY women|nmod|tolerance resistance|nmod|women Enhanced|nmod|resistance Enhanced|dobj|response response|compound|END_ENTITY	Enhanced early insulin response to glucose in relation to insulin resistance in women with polycystic_ovary_syndrome and normal glucose tolerance .
8175959	0	glucose	128,135	insulin	58,65	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY women|nmod|tolerance resistance|nmod|women resistance|compound|END_ENTITY	Enhanced early insulin response to glucose in relation to insulin resistance in women with polycystic_ovary_syndrome and normal glucose tolerance .
8175959	0	glucose	35,42	insulin	15,22	glucose	insulin	MESH:D005947	3630	Chemical	Gene	Enhanced|nmod|START_ENTITY Enhanced|dobj|response response|compound|END_ENTITY	Enhanced early insulin response to glucose in relation to insulin resistance in women with polycystic_ovary_syndrome and normal glucose tolerance .
8175959	0	glucose	35,42	insulin	58,65	glucose	insulin	MESH:D005947	3630	Chemical	Gene	Enhanced|nmod|START_ENTITY Enhanced|nmod|resistance resistance|compound|END_ENTITY	Enhanced early insulin response to glucose in relation to insulin resistance in women with polycystic_ovary_syndrome and normal glucose tolerance .
8181251	0	glucose	140,147	insulin	6,13	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY subjects|nmod|tolerance study|nmod|subjects level|dep|study level|compound|END_ENTITY	Serum insulin level versus blood pressure : a cross-sectional , case-controlled study in non-obese , middle-aged Japanese subjects with normal glucose tolerance .
8192262	0	glucose	41,48	insulin	6,13	glucose	insulin	MESH:D005947	100060077(Tax:9796)	Chemical	Gene	tolerance|compound|START_ENTITY response|nmod|tolerance response|compound|END_ENTITY	Early insulin response to an intravenous glucose tolerance test in horses .
819601	0	glucose	60,67	insulin	27,34	glucose	insulin	MESH:D005947	704534(Tax:9544)	Chemical	Gene	responses|nmod|START_ENTITY responses|compound|END_ENTITY	Portal and peripheral vein insulin responses to intravenous glucose in the rhesus_monkey .
8199238	0	glucose	78,85	insulin	55,62	glucose	insulin	MESH:D005947	3630	Chemical	Gene	concentration|compound|START_ENTITY releases|nmod|concentration releases|dobj|END_ENTITY	Design and synthesis of a protein device that releases insulin in response to glucose concentration .
8216497	0	glucose	50,57	insulin	32,39	glucose	insulin	MESH:D005947	3630	Chemical	Gene	parameters|compound|START_ENTITY Effects|nmod|parameters Effects|nmod|levels levels|compound|END_ENTITY	Effects of physiological plasma insulin levels on glucose turnover parameters in familial_hypercholesterolemia .
8224036	0	glucose	58,65	insulin	37,44	glucose	insulin	MESH:D005947	3630	Chemical	Gene	disposal|compound|START_ENTITY infusions|nmod|disposal infusions|nsubj|effects effects|nmod|END_ENTITY	The effects of single and sequential insulin infusions on glucose disposal in older men .
8226749	1	glucose	129,136	insulin	157,164	glucose	insulin	MESH:D005947	3630	Chemical	Gene	secretion|compound|START_ENTITY secretion|compound|END_ENTITY	Possible role in glucose and agonist-induced insulin secretion .
8243823	0	glucose	34,41	insulin	74,81	glucose	insulin	MESH:D005947	3630	Chemical	Gene	system|compound|START_ENTITY defects|nmod|system cause|nsubj|defects cause|dobj|resistance resistance|compound|END_ENTITY	Multiple defects in the adipocyte glucose transport system cause cellular insulin resistance in gestational_diabetes .
8243878	0	glucose	111,118	insulin	62,69	glucose	insulin	MESH:D005947	3630	Chemical	Gene	counterregulation|nmod|START_ENTITY END_ENTITY|nmod|counterregulation	Effects of recombinant human insulin-like growth factor I and insulin on counterregulation during acute plasma glucose decrements in normal and type 2 -LRB- non-insulin-dependent -RRB- diabetic subjects .
8249680	0	glucose	42,49	insulin	20,27	glucose	insulin	MESH:D005947	3630	Chemical	Gene	fluxes|compound|START_ENTITY regulating|dobj|fluxes END_ENTITY|acl|regulating	Indirect effects of insulin in regulating glucose fluxes .
8252839	0	glucose	26,33	insulin	63,70	glucose	insulin	MESH:D005947	280829(Tax:9913)	Chemical	Gene	responsiveness|compound|START_ENTITY responsiveness|nmod|END_ENTITY	Insulin responsiveness to glucose and tissue responsiveness to insulin during lactation in dairy cows .
8255887	0	glucose	21,28	insulin	50,57	glucose	insulin	MESH:D005947	101823595	Chemical	Gene	stimuli|compound|START_ENTITY stimuli|nmod|patterns patterns|compound|END_ENTITY	Effects of pulsatile glucose stimuli on long-term insulin secretory patterns in islets of Langerhans microdissected from Syrian_hamsters .
8270134	0	glucose	106,113	insulin	78,85	glucose	insulin	MESH:D005947	3630	Chemical	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	Hepatic glucose production during intraperitoneal and intravenous closed-loop insulin regulation of blood glucose in type 1 -LRB- insulin-dependent -RRB- diabetic patients .
8282776	0	glucose	46,53	insulin	13,20	glucose	insulin	MESH:D005947	3630	Chemical	Gene	rates|compound|START_ENTITY determine|dobj|rates determine|nsubj|concentrations concentrations|compound|END_ENTITY	Interstitial insulin concentrations determine glucose uptake rates but not insulin resistance in lean and obese men .
8282776	6	glucose	1038,1045	insulin	1098,1105	glucose	insulin	MESH:D005947	3630	Chemical	Gene	uptake|nsubj|START_ENTITY uptake|nmod|concentrations concentrations|compound|END_ENTITY	In each individual , the glucose uptake closely correlated with peripheral lymphatic insulin concentrations -LRB- mean r2 = 0.95 -RRB- .
8282776	7	glucose	1160,1167	insulin	1214,1221	glucose	insulin	MESH:D005947	3630	Chemical	Gene	uptake|compound|START_ENTITY uptake|appos|END_ENTITY	The coupling between glucose uptake and lymph insulin -LRB- glucose uptake/pmol insulin -RRB- was much steeper in lean subjects than in the obese -LRB- P < or = 0.0001 -RRB- .
8288041	0	glucose	12,19	insulin	70,77	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	production|compound|START_ENTITY Dynamics|nmod|production related|nsubj|Dynamics related|nmod|END_ENTITY	Dynamics of glucose production and uptake are more closely related to insulin in hindlimb lymph than in thoracic duct lymph .
8293864	0	glucose	58,65	insulin	38,45	glucose	insulin	MESH:D005947	3630	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Predictive value of age-related acute insulin response to glucose in subjects at risk for type 1 diabetes : results of a 6-year follow-up study from west-France .
8299437	0	glucose	87,94	insulin	142,149	glucose	insulin	MESH:D005947	3630	Chemical	Gene	variability|compound|START_ENTITY variability|acl:relcl|compared compared|nmod|END_ENTITY	Jet-injected insulin is associated with decreased antibody production and postprandial glucose variability when compared with needle-injected insulin in gestational diabetic women .
8299456	0	glucose	61,68	insulin	35,42	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY predict|dobj|tolerance predict|nsubj|secretion secretion|compound|END_ENTITY	Prepregnancy weight and antepartum insulin secretion predict glucose tolerance five years after gestational diabetes_mellitus .
8304917	0	glucose	21,28	insulin	10,17	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	metabolism|compound|START_ENTITY Action|nmod|metabolism Action|nmod|END_ENTITY	Action of insulin on glucose metabolism in vivo .
8325952	0	glucose	44,51	insulin	171,178	glucose	insulin	MESH:D005947	3630	Chemical	Gene	transporter|compound|START_ENTITY regulatable|dobj|transporter regulatable|nmod|infusion infusion|compound|END_ENTITY	Expression of the major insulin regulatable glucose transporter -LRB- GLUT4 -RRB- in skeletal muscle of noninsulin-dependent diabetic patients and healthy subjects before and after insulin infusion .
8325952	0	glucose	44,51	insulin	24,31	glucose	insulin	MESH:D005947	3630	Chemical	Gene	transporter|compound|START_ENTITY regulatable|dobj|transporter regulatable|nsubj|Expression Expression|nmod|END_ENTITY	Expression of the major insulin regulatable glucose transporter -LRB- GLUT4 -RRB- in skeletal muscle of noninsulin-dependent diabetic patients and healthy subjects before and after insulin infusion .
8326015	0	glucose	30,37	insulin	10,17	glucose	insulin	MESH:D005947	3630	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Decreased insulin response to glucose in islet cell antibody-negative siblings of type 1 diabetic children .
8326016	0	glucose	38,45	insulin	85,92	glucose	insulin	MESH:D005947	3630	Chemical	Gene	concentrations|compound|START_ENTITY cells|nmod|concentrations exposure|nmod|cells decreases|nsubj|exposure decreases|dobj|transcription transcription|compound|END_ENTITY	Chronic exposure of HIT cells to high glucose concentrations paradoxically decreases insulin gene transcription and alters binding of insulin gene regulatory protein .
8334821	0	glucose	15,22	insulin	34,41	glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY control|nmod|therapy therapy|compound|END_ENTITY	Improved blood glucose control by insulin therapy in type 2 diabetic patients has no effect on lipoprotein -LRB- a -RRB- levels .
8375272	3	glucose	624,631	insulin	500,507	glucose	insulin	MESH:D005947	3630	Chemical	Gene	infusion|compound|START_ENTITY made|nmod|infusion made|nmod|U/kg U/kg|nmod|END_ENTITY	With 0.3 U/kg of insulin , the rate of fall in glycemia and the nadir of blood glucose were made similar to those with 0.1 U/kg of insulin by glucose infusion with artificial endocrine pancreas .
838169	0	glucose	27,34	insulin	59,66	glucose	insulin	MESH:D005947	3630	Chemical	Gene	concentration|compound|START_ENTITY fasting|dobj|concentration fasting|nmod|END_ENTITY	Relation of fasting plasma glucose concentration to plasma insulin and glucagon concentrations .
8384164	0	glucose	96,103	insulin	63,70	glucose	insulin	MESH:D005947	3630	Chemical	Gene	response|nmod|START_ENTITY secretion|nmod|response secretion|compound|END_ENTITY	Very low calorie diet-induced weight_loss reverses exaggerated insulin secretion in response to glucose , arginine and glucagon in obesity .
8386610	0	glucose	30,37	insulin	81,88	glucose	insulin	MESH:D005947	3630	Chemical	Gene	dependence|compound|START_ENTITY dependence|nmod|secretion secretion|compound|END_ENTITY	The mechanisms underlying the glucose dependence of arginine_vasopressin-induced insulin secretion in beta-cells .
8403806	0	glucose	77,84	insulin	21,28	glucose	insulin	MESH:D005947	3630	Chemical	Gene	ingestion|compound|START_ENTITY Relationship|nmod|ingestion Relationship|nmod|release release|compound|END_ENTITY	Relationship between insulin release , antinatriuresis and hypokalaemia after glucose ingestion in normal and hypertensive man .
8403824	0	glucose	116,123	insulin	82,89	glucose	insulin	MESH:D005947	3630	Chemical	Gene	excursions|compound|START_ENTITY sulphonylurea-stimulated|nmod|excursions sulphonylurea-stimulated|dobj|secretion secretion|compound|END_ENTITY	The acute effect of preprandial exogenous and endogenous sulphonylurea-stimulated insulin secretion on postprandial glucose excursions in patients with type 2 diabetes .
8412338	0	glucose	51,58	insulin	7,14	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY END_ENTITY|nmod|tolerance	Plasma insulin and blood pressure response to oral glucose tolerance test in young borderline hypertensives .
8412519	0	glucose	15,22	insulin	36,43	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY tolerance|nmod|END_ENTITY	Improvement in glucose tolerance of insulin resistant rats after chronic or acute administration of benfluorex .
8424283	0	glucose	82,89	insulin	57,64	glucose	insulin	MESH:D005947	3630	Chemical	Gene	infusion|compound|START_ENTITY response|nmod|infusion response|compound|END_ENTITY	Comparison of two anesthesia techniques on perioperative insulin response to i.v. glucose infusion in children .
8432418	0	glucose	63,70	insulin	8,15	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	effectiveness|compound|START_ENTITY impairs|dobj|effectiveness impairs|nsubj|secretion secretion|compound|END_ENTITY	Reduced insulin secretion by repeated low doses of STZ impairs glucose effectiveness but does not induce insulin resistance in dogs .
845355	0	glucose	42,49	insulin	34,41	glucose	insulin	MESH:D005947	3630	Chemical	Gene	relationship|compound|START_ENTITY relationship|compound|END_ENTITY	A device for expressing the serum insulin glucose relationship in diabetes , hyper - _ or_hypothyroidsm , and chronic hepatitis .
8473402	0	glucose	24,31	insulin	92,99	glucose	insulin	MESH:D005947	3630	Chemical	Gene	stimulation|compound|START_ENTITY effects|nmod|stimulation effects|nmod|secretion secretion|compound|END_ENTITY	Differential effects of glucose stimulation upon rapid pulses and ultradian oscillations of insulin secretion .
8527229	0	glucose	32,39	insulin	21,28	glucose	insulin	MESH:D005947	3630	Chemical	Gene	transport|compound|START_ENTITY actions|nmod|transport actions|nmod|END_ENTITY	Molecular actions of insulin on glucose transport .
8529809	0	glucose	28,35	insulin	16,23	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY Significance|nmod|metabolism Significance|nmod|END_ENTITY	Significance of insulin for glucose metabolism in skeletal muscle during contractions .
8530440	1	glucose	127,134	insulin	106,113	glucose	insulin	MESH:D005947	3630	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Diabetes_mellitus Diabetes_mellitus|amod|due due|nmod|END_ENTITY	Diabetes_mellitus due to defective insulin secretion to glucose .
8536147	2	glucose	392,399	insulin	315,322	glucose	insulin	MESH:D005947	3630	Chemical	Gene	load|compound|START_ENTITY response|nmod|load accompanied|nmod|response accompanied|nsubjpass|action action|compound|END_ENTITY	This enhanced insulin action is accompanied by a decreased insulin response during an oral glucose load .
8544782	0	glucose	22,29	insulin	11,18	glucose	insulin	MESH:D005947	3630	Chemical	Gene	rates|compound|START_ENTITY END_ENTITY|nmod|rates	Effects of insulin on glucose turnover rates in vivo : isotope dilution versus constant specific activity technique .
8546639	0	glucose	6,13	insulin	48,55	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY Using|dobj|tolerance test|csubj|Using test|xcomp|predict predict|dobj|requirement requirement|compound|END_ENTITY	Using glucose tolerance test results to predict insulin requirement in women with gestational_diabetes .
856649	0	glucose	36,43	insulin	6,13	glucose	insulin	MESH:D005947	3630	Chemical	Gene	infusion|compound|START_ENTITY Serum|nmod|infusion Serum|dobj|response response|compound|END_ENTITY	Serum insulin response to slow-rise glucose infusion in `` genetic prediabetics '' -LRB- offspring of two diabetic parents -RRB- .
858443	0	glucose	28,35	insulin	110,117	glucose	insulin	MESH:D005947	3630	Chemical	Gene	assimilation|compound|START_ENTITY Study|nmod|assimilation Study|acl|deprived deprived|nmod|END_ENTITY	Study of the coefficient of glucose assimilation during muscular exercise in diabetic adolescents deprived of insulin .
8591813	0	glucose	83,90	insulin	65,72	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	metabolism|compound|START_ENTITY dimers|nmod|metabolism dimers|nsubj|Demonstration Demonstration|nmod|effect effect|nmod|END_ENTITY	Demonstration of a relatively hepatoselective effect of covalent insulin dimers on glucose metabolism in dogs .
8613231	0	glucose	66,73	insulin	40,47	glucose	insulin	MESH:D005947	3630	Chemical	Gene	action|compound|START_ENTITY related|nmod|action related|advmod|more more|nmod|fatty_acid fatty_acid|nmod:poss|END_ENTITY	Obesity hypertension is related more to insulin 's fatty_acid than glucose action .
8613527	0	glucose	73,80	insulin	114,121	glucose	insulin	MESH:D005947	3630	Chemical	Gene	concentrations|nmod|START_ENTITY cells|nmod|concentrations exposure|nmod|cells decreases|nsubj|exposure decreases|dobj|binding binding|nmod|activator activator|compound|END_ENTITY	Chronic exposure of betaTC-6 cells to supraphysiologic concentrations of glucose decreases binding of the RIPE3b1 insulin gene transcription activator .
8613896	0	glucose	124,131	insulin	43,50	glucose	insulin	MESH:D005947	105613195	Chemical	Gene	infusion|compound|START_ENTITY Changes|nmod|infusion Changes|nmod|END_ENTITY	Changes in gut and liver glucose , lactate , insulin , and oxygen flux in mature ewes during mesenteric or abdominal vena cava glucose infusion .
862563	0	glucose	26,33	insulin	64,71	glucose	insulin	MESH:D005947	3630	Chemical	Gene	concentration|compound|START_ENTITY concentration|nmod|signal signal|nmod|release release|compound|END_ENTITY	Role of rate of change of glucose concentration as a signal for insulin release .
8626958	0	glucose	75,82	insulin	55,62	glucose	insulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY Impaired_glucose_tolerance|nmod|test Impaired_glucose_tolerance|nmod|hypersecretion hypersecretion|nmod|END_ENTITY	Impaired_glucose_tolerance with late hypersecretion of insulin during oral glucose tolerance test in patients with vasospastic_angina .
8636369	0	glucose	152,159	insulin	15,22	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY lower|nmod|tolerance lower|nsubj|Improvement Improvement|nmod|sensitivity sensitivity|compound|END_ENTITY	Improvement of insulin sensitivity by metformin treatment does not lower blood pressure of nonobese insulin-resistant hypertensive patients with normal glucose tolerance .
8641378	0	glucose	74,81	insulin	35,42	glucose	insulin	MESH:D005947	3630	Chemical	Gene	level|compound|START_ENTITY regulation|nmod|level thoughts|nmod|regulation thoughts|nmod|importance importance|nmod|END_ENTITY	Some thoughts on the importance of insulin in the regulation of the blood glucose level .
8665779	0	glucose	47,54	insulin	27,34	glucose	insulin	MESH:D005947	3630	Chemical	Gene	uptake|compound|START_ENTITY metabolism|dep|uptake metabolism|nmod|resistance resistance|compound|END_ENTITY	Carbohydrate metabolism in insulin resistance : glucose uptake and lactate production by adipose and forearm tissues in vivo before and after a mixed meal .
8665805	0	glucose	56,63	insulin	4,11	glucose	insulin	MESH:D005947	105613195	Chemical	Gene	clearance|compound|START_ENTITY status|nmod|clearance status|compound|END_ENTITY	The insulin status of sheep with genetic differences in glucose clearance .
8670061	0	glucose	24,31	insulin	113,120	glucose	insulin	MESH:D005947	3630	Chemical	Gene	transport|compound|START_ENTITY increases|dobj|transport increases|nmod|mechanism mechanism|amod|different different|nmod|that that|nmod|END_ENTITY	Noradrenaline increases glucose transport into brown adipocytes in culture by a mechanism different from that of insulin .
8674890	0	glucose	55,62	insulin	11,18	glucose	insulin	MESH:D005947	3630	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of insulin and IGF-I on vascular smooth muscle glucose and cation metabolism .
8684772	2	glucose	258,265	insulin	225,232	glucose	insulin	MESH:D005947	3630	Chemical	Gene	response|nmod|START_ENTITY secretion|nmod|response secretion|compound|END_ENTITY	In early_pregnancy , insulin secretion in response to glucose is increased , peripheral insulin sensitivity is normal or increased , glucose tolerance is normal or slightly enhanced .
8684772	2	glucose	335,342	insulin	225,232	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY normal|nsubjpass|tolerance increased|parataxis|normal increased|nsubjpass|secretion secretion|compound|END_ENTITY	In early_pregnancy , insulin secretion in response to glucose is increased , peripheral insulin sensitivity is normal or increased , glucose tolerance is normal or slightly enhanced .
8698866	0	glucose	81,88	insulin	23,30	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	output|compound|START_ENTITY linkage|nmod|output linkage|nmod|suppression suppression|compound|END_ENTITY	Causal linkage between insulin suppression of lipolysis and suppression of liver glucose output in dogs .
8705254	0	glucose	78,85	insulin	16,23	glucose	insulin	MESH:D005947	3630	Chemical	Gene	sensitive|advmod|START_ENTITY membrane|amod|sensitive governed|nmod|membrane governed|nsubj|delivery delivery|nmod|END_ENTITY	The delivery of insulin from aqueous and non-aqueous reservoirs governed by a glucose sensitive gel membrane .
8719932	0	glucose	139,146	insulin	61,68	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	metabolism|compound|START_ENTITY comparison|nmod|metabolism comparison|nmod|effects effects|nmod|infusions infusions|compound|END_ENTITY	A comparison of the effects of insulin-like_growth_factor-I , insulin and combined infusions of insulin_and_insulin-like_growth_factor-I on glucose metabolism in dogs .
873587	0	glucose	50,57	insulin	33,40	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	levels|compound|START_ENTITY Effect|nmod|levels Effect|nmod|END_ENTITY	Effect of centrally administered insulin on blood glucose levels in dogs .
8764306	0	glucose	34,41	insulin	74,81	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY improves|dobj|tolerance improves|parataxis|effects effects|nmod|END_ENTITY	Oral sensory stimulation improves glucose tolerance in humans : effects on insulin , C-peptide , and glucagon .
8772733	1	glucose	138,145	insulin	127,134	glucose	insulin	MESH:D005947	3630	Chemical	Gene	turnover|compound|START_ENTITY effects|nmod|turnover effects|nmod|END_ENTITY	Dose-response effects of insulin on glucose turnover .
8810734	0	glucose	11,18	insulin	43,50	glucose	insulin	MESH:D005947	3630	Chemical	Gene	load|compound|START_ENTITY Effects|nmod|load arginine|nsubj|Effects arginine|nmod|END_ENTITY	Effects of glucose load and/or arginine on insulin and growth_hormone secretion in hyperprolactinemia and obesity .
8826965	0	glucose	11,18	insulin	58,65	glucose	insulin	MESH:D005947	3630	Chemical	Gene	ingestion|compound|START_ENTITY Effects|nmod|ingestion Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of glucose ingestion versus infusion on pulsatile insulin secretion .
8842473	0	glucose	37,44	insulin	60,67	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY alterations|nmod|tolerance alterations|dep|responses responses|compound|END_ENTITY	Dexamethasone-induced alterations in glucose tolerance and , insulin , glucagon and adrenaline responses during the first month in White Leghorn chicks .
8843732	0	glucose	106,113	insulin	14,21	glucose	insulin	MESH:D005947	3630	Chemical	Gene	stimulus|compound|START_ENTITY secretion|nmod|stimulus END_ENTITY|acl|secretion	Regulation of insulin secretion by phospholipase C. Biphasic insulin secretion in response to a sustained glucose stimulus occurs when rat or human islets are exposed to high levels of the hexose .
8845794	0	glucose	57,64	insulin	36,43	glucose	insulin	MESH:D005947	3630	Chemical	Gene	-RSB-|compound|START_ENTITY secretion|nmod|-RSB- secretion|nsubj|Hierarchy Hierarchy|nmod|mechanisms mechanisms|nmod|END_ENTITY	-LSB- Hierarchy of control mechanisms of insulin secretion by glucose -RSB- .
8846678	0	glucose	27,34	insulin	169,176	glucose	insulin	MESH:D005947	3630	Chemical	Gene	START_ENTITY|dep|role role|nmod|sensitivity sensitivity|compound|END_ENTITY	More uniform diurnal blood glucose control and a reduction in daily insulin dosage on addition of glibenclamide to insulin in type 1 diabetes_mellitus : role of enhanced insulin sensitivity .
8849464	0	glucose	80,87	insulin	49,56	glucose	insulin	MESH:D005947	3630	Chemical	Gene	stimulus|compound|START_ENTITY reconstruct|nmod|stimulus reconstruct|dobj|rate rate|compound|END_ENTITY	A stochastic deconvolution method to reconstruct insulin secretion rate after a glucose stimulus .
8862219	0	glucose	52,59	insulin	15,22	glucose	insulin	MESH:D005947	3630	Chemical	Gene	responses|nmod|START_ENTITY responses|compound|END_ENTITY	Differences in insulin and sympathetic responses to glucose ingestion due to family history of hypertension .
8866556	0	glucose	38,45	insulin	17,24	glucose	insulin	MESH:D005947	3630	Chemical	Gene	Normalization|acl|START_ENTITY Normalization|nmod|responses responses|compound|END_ENTITY	Normalization of insulin responses to glucose by overnight infusion of glucagon-like_peptide_1 -LRB- 7-36 -RRB- amide in patients with NIDDM .
8881595	0	glucose	114,121	insulin	73,80	glucose	insulin	MESH:D005947	280829(Tax:9913)	Chemical	Gene	supply|compound|START_ENTITY lactating|nmod|supply lactating|nmod|administration administration|compound|END_ENTITY	Modulation of the feeding response of lactating dairy cows to peripheral insulin administration with or without a glucose supply .
8894494	0	glucose	25,32	insulin	154,161	glucose	insulin	MESH:D005947	3630	Chemical	Gene	load|compound|START_ENTITY response|nmod|load decreased|nsubjpass|response decreased|nmod|non-insulin-dependent_diabetes_mellitus non-insulin-dependent_diabetes_mellitus|dep|usefulness usefulness|nmod|response response|compound|END_ENTITY	Insulin response to oral glucose load is consistently decreased in established non-insulin-dependent_diabetes_mellitus : the usefulness of decreased early insulin response as a predictor of non-insulin-dependent_diabetes_mellitus .
8944672	0	glucose	14,21	insulin	53,60	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	distribution|compound|START_ENTITY altered|nsubjpass|distribution altered|nmod|END_ENTITY	Extracellular glucose distribution is not altered by insulin : analysis of plasma and interstitial L-glucose kinetics .
8946442	0	glucose	84,91	insulin	101,108	glucose	insulin	MESH:D005947	704534(Tax:9544)	Chemical	Gene	START_ENTITY|nmod|resistant resistant|compound|END_ENTITY	Dietary myoinositol results in lower urine glucose and in lower postprandial plasma glucose in obese insulin resistant rhesus_monkeys .
9000693	0	glucose	82,89	insulin	63,70	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	production|compound|START_ENTITY mediating|nmod|production mediating|dobj|effects effects|nmod|END_ENTITY	The role of fatty_acids in mediating the effects of peripheral insulin on hepatic glucose production in the conscious dog .
9022089	0	glucose	19,26	insulin	96,103	glucose	insulin	MESH:D005947	3630	Chemical	Gene	Differentiation|nmod|START_ENTITY toxicity|nsubj|Differentiation toxicity|nmod|evolution evolution|nmod|expression expression|compound|END_ENTITY	Differentiation of glucose toxicity from beta cell exhaustion during the evolution of defective insulin gene expression in the pancreatic islet cell line , HIT-T15 .
9029356	0	glucose	44,51	insulin	20,27	glucose	insulin	MESH:D005947	280829(Tax:9913)	Chemical	Gene	tests|compound|START_ENTITY effects|nmod|tests effects|nmod|response response|compound|END_ENTITY	Acidosis effects on insulin response during glucose tolerance tests in Jersey cows .
9038856	0	glucose	11,18	insulin	68,75	glucose	insulin	MESH:D005947	3630	Chemical	Gene	production|compound|START_ENTITY Persistent|dobj|production Persistent|nmod|END_ENTITY	Persistent glucose production and greater peripheral sensitivity to insulin in the neonate vs. the adult .
9048601	0	glucose	54,61	insulin	31,38	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	production|compound|START_ENTITY suppressing|dobj|production END_ENTITY|acl|suppressing	Direct and indirect effects of insulin in suppressing glucose production in depancreatized dogs : role of glucagon .
9075065	0	glucose	103,110	insulin	50,57	glucose	insulin	MESH:D005947	3630	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|response response|compound|END_ENTITY	Effects of cholinergic blockade by pirenzepine on insulin and glucose response to oral and intravenous glucose and to arginine load in obesity .
909020	0	glucose	64,71	insulin	44,51	glucose	insulin	MESH:D005947	3630	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Lack of gastrointestinal enhancement of the insulin response to glucose in newborn infants .
9101062	0	glucose	105,112	insulin	55,62	glucose	insulin	MESH:D005947	3630	Chemical	Gene	production|compound|START_ENTITY regulation|nmod|production role|nmod|regulation role|nmod|END_ENTITY	Glucose metabolism during exercise in man : the role of insulin and glucagon in the regulation of hepatic glucose production and gluconeogenesis .
9101063	0	glucose	84,91	insulin	55,62	glucose	insulin	MESH:D005947	3630	Chemical	Gene	utilization|compound|START_ENTITY regulation|nmod|utilization END_ENTITY|nmod|regulation	Glucose metabolism during exercise in man : the role of insulin in the regulation of glucose utilization .
9112973	0	glucose	40,47	insulin	11,18	glucose	insulin	MESH:D005947	3630	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of insulin under normal and low glucose on retinal electrophysiology in the perfused cat eye .
9144560	0	glucose	79,86	insulin	21,28	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	concentration|compound|START_ENTITY ambient|dobj|concentration responds|xcomp|ambient responds|nsubj|release release|nmod|cells cells|compound|END_ENTITY	The IRI release from insulin gene-transduced hepatic cells responds to ambient glucose concentration .
9159118	0	glucose	51,58	insulin	79,86	glucose	insulin	MESH:D005947	3630	Chemical	Gene	kinase|nmod|START_ENTITY Activation|nmod|kinase required|nsubjpass|Activation required|nmod|secretion secretion|compound|END_ENTITY	Activation of mitogen-activating protein kinase by glucose is not required for insulin secretion .
9186311	0	glucose	32,39	insulin	81,88	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|nmod|absence absence|nmod|END_ENTITY	Acute effect of troglitazone on glucose metabolism in the absence or presence of insulin in perfused rat hindlimb .
9205938	0	glucose	94,101	insulin	33,40	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY increase|nmod|metabolism due|nmod|increase due|nsubj|improvement improvement|nmod|action action|compound|END_ENTITY	Losartan mediated improvement in insulin action is mainly due to an increase in non-oxidative glucose metabolism and blood flow in insulin-resistant hypertensive patients .
9225841	0	glucose	22,29	insulin	90,97	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|dep|effects effects|nmod|doses doses|compound|END_ENTITY	Impaired nonoxidative glucose metabolism in patients with liver_cirrhosis : effects of two insulin doses .
9259575	0	glucose	107,114	insulin	7,14	glucose	insulin	MESH:D005947	3630	Chemical	Gene	uptake|compound|START_ENTITY not|nmod|uptake Intact|dep|not Intact|dobj|stimulation stimulation|compound|END_ENTITY	Intact insulin stimulation of skeletal muscle blood flow , its heterogeneity and redistribution , but not of glucose uptake in non-insulin-dependent_diabetes_mellitus .
9286467	0	glucose	88,95	insulin	108,115	glucose	insulin	MESH:D005947	3630	Chemical	Gene	sensitivity|compound|START_ENTITY sensitivity|dep|END_ENTITY	Comparison of the effects of two weeks ' intervention with different meal frequencies on glucose metabolism , insulin sensitivity and lipid levels in non-insulin-dependent diabetic patients .
9314631	0	glucose	72,79	insulin	48,55	glucose	insulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY improves|dobj|control improves|nsubj|Modification Modification|nmod|hyperglycemia hyperglycemia|nmod|lispro lispro|compound|END_ENTITY	Modification of postprandial hyperglycemia with insulin lispro improves glucose control in patients with type 2 diabetes .
9322792	0	glucose	32,39	insulin	14,21	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	uptake|compound|START_ENTITY action|nmod|uptake action|compound|END_ENTITY	Assessment of insulin action on glucose uptake and production during a euglycemic-hyperinsulinemic_clamp in dog : a new kinetic analysis .
9338524	0	glucose	40,47	insulin	78,85	glucose	insulin	MESH:D005947	3630	Chemical	Gene	production|compound|START_ENTITY reduces|dobj|production reduces|nmod|END_ENTITY	Glucagon-like_peptide-1 reduces hepatic glucose production indirectly through insulin and glucagon in humans .
9350591	7	glucose	1038,1045	insulin	1105,1112	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY period|appos|tolerance studied|nmod|period studied|advcl|administering administering|dobj|resistance resistance|dep|END_ENTITY	We studied basal insulin-secretion patterns during a 60 min period , glucose tolerance by administering an oral glucose-tolerance test , insulin resistance by using an isoglycaemic hyperinsulinaemic clamp and basal plasma catecholamine levels .
936702	0	glucose	55,62	insulin	40,47	glucose	insulin	MESH:D005947	3630	Chemical	Gene	infusion|compound|START_ENTITY END_ENTITY|nmod|infusion	-LSB- Carbohydrate tolerance and behavior of insulin in the glucose infusion test in persons with normal weight with prediabetic suspicion -RSB- .
9388585	0	glucose	120,127	insulin	68,75	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY involved|nmod|metabolism sufficient|dep|involved sufficient|nsubj|stimulation stimulation|nmod|activity activity|nmod|END_ENTITY	Is stimulation of class-1 phosphatidylinositol 3-kinase activity by insulin sufficient to activate pathways involved in glucose metabolism .
9389422	0	glucose	51,58	insulin	14,21	glucose	insulin	MESH:D005947	3630	Chemical	Gene	production|compound|START_ENTITY inhibit|dobj|production inhibit|nsubj|Evidence Evidence|dep|END_ENTITY	Evidence that insulin can directly inhibit hepatic glucose production .
9392315	2	glucose	468,475	insulin	364,371	glucose	insulin	MESH:D005947	3630	Chemical	Gene	measured|dobj|START_ENTITY measured|advcl|examine examine|nmod|regulation regulation|compound|END_ENTITY	To examine the effect of troglitazone on insulin regulation after pancreas_transplantation_with_systemic_venous_drainage , we measured peripheral glucose and insulin levels and performed an intravenous glucose tolerance test .
9399959	0	glucose	50,57	insulin	19,26	glucose	insulin	MESH:D005947	3630	Chemical	Gene	production|compound|START_ENTITY suppress|dobj|production END_ENTITY|acl|suppress	Indirect effect of insulin to suppress endogenous glucose production is dominant , even with hyperglucagonemia .
9410723	0	glucose	22,29	insulin	11,18	glucose	insulin	MESH:D005947	105613195	Chemical	Gene	and|compound|START_ENTITY Effect|nmod|and Effect|nmod|END_ENTITY	-LSB- Effect of insulin on glucose and and fat metabolism in ewes during various reproductive states in normal and hypocalcemia -RSB- .
9426377	0	glucose	76,83	insulin	56,63	glucose	insulin	MESH:D005947	3630	Chemical	Gene	load|compound|START_ENTITY increases|nmod|load increases|dobj|response response|compound|END_ENTITY	Cholinergic enhancement by pyridostigmine increases the insulin response to glucose load in obese patients but not in normal subjects .
943248	0	glucose	43,50	insulin	20,27	glucose	insulin	MESH:D005947	3630	Chemical	Gene	-RSB-|compound|START_ENTITY secretion|nmod|-RSB- secretion|nmod|END_ENTITY	-LSB- Fetal secretion of insulin in response to glucose loading -RSB- .
9439551	1	glucose	248,255	insulin	172,179	glucose	insulin	MESH:D005947	3630	Chemical	Gene	contribution|nmod|START_ENTITY stimulate|nmod|contribution stimulate|dobj|secretion secretion|compound|END_ENTITY	Sulfonylureas stimulate insulin secretion as their predominant contribution toward decreasing blood glucose in diabetic patients .
946563	0	glucose	50,57	insulin	30,37	glucose	insulin	MESH:D005947	3630	Chemical	Gene	sensitivity|nmod|START_ENTITY sensitivity|nmod|response response|compound|END_ENTITY	Diminished sensitivity of the insulin response to glucose following growth_hormone influsion in man .
9513368	0	glucose	78,85	insulin	16,23	glucose	insulin	MESH:D005947	3630	Chemical	Gene	-RSB-|compound|START_ENTITY measured|nmod|-RSB- measured|nsubj|Improvement Improvement|nmod|sensitivity sensitivity|compound|END_ENTITY	-LSB- Improvement of insulin sensitivity after renal transplantation measured by a glucose clamp technique -RSB- .
9519739	0	glucose	56,63	insulin	78,85	glucose	insulin	MESH:D005947	3630	Chemical	Gene	effect|nmod|START_ENTITY mimic|dobj|effect mimic|advcl|augmenting augmenting|dobj|release release|compound|END_ENTITY	Palmitate and myristate selectively mimic the effect of glucose in augmenting insulin release in the absence of extracellular Ca2 + .
9526175	0	glucose	44,51	insulin	52,59	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|compound|END_ENTITY	Effect of acute carnitine administration on glucose insulin metabolism in healthy subjects .
9527077	0	glucose	56,63	insulin	23,30	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY secretion|nmod|tolerance secretion|compound|END_ENTITY	Usefulness of enhanced insulin secretion during an oral glucose tolerance test as a predictor of restenosis after direct percutaneous transluminal coronary angioplasty during acute_myocardial_infarction in patients without diabetes_mellitus .
9532827	12	glucose	1839,1846	insulin	1979,1986	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	challenge|compound|START_ENTITY IRI|nmod|challenge peaked|nsubj|IRI peaked|parataxis|exhibited exhibited|dobj|shortage shortage|compound|END_ENTITY	In diabetic bitches at A , serum IRI after glucose challenge peaked higher than in respective normal controls -LRB- insulin clearance and insulin DS were similar -RRB- : they exhibited relative insulin shortage and resistance to insulin hypoglycemic action partly compensated by promoted insulin secretion .
9538967	0	glucose	59,66	insulin	18,25	glucose	insulin	MESH:D005947	3630	Chemical	Gene	lispro|nmod|START_ENTITY lispro|compound|END_ENTITY	The effect of the insulin analog lispro on nighttime blood glucose control in type 1 diabetic patients .
9568806	0	glucose	51,58	insulin	111,118	glucose	insulin	MESH:D005947	3630	Chemical	Gene	glucagon-like_peptide_1|nmod|START_ENTITY Effects|nmod|glucagon-like_peptide_1 kinetics|nsubj|Effects kinetics|nmod|suppression suppression|nmod|secretion secretion|compound|END_ENTITY	Effects of glucagon-like_peptide_1 -LRB- 7-36 amide -RRB- on glucose kinetics during somatostatin-induced suppression of insulin secretion in healthy men .
9585399	6	glucose	827,834	insulin	846,853	glucose	insulin	MESH:D005947	3630	Chemical	Gene	START_ENTITY|acl|stimulated stimulated|dobj|levels levels|compound|END_ENTITY	Elevated NEFA levels -LRB- approximately 4000 micromol l -LRB- -1 -RRB- -RRB- did not enhance basal or first phase glucose stimulated insulin levels .
9606751	0	glucose	67,74	insulin	104,111	glucose	insulin	MESH:D005947	105613195	Chemical	Gene	responsiveness|compound|START_ENTITY responsiveness|nmod|responsiveness responsiveness|nmod|END_ENTITY	The effect of supplemental_propionate on insulin responsiveness to glucose and tissue responsiveness to insulin in relation to feeding in sheep .
9606751	0	glucose	67,74	insulin	41,48	glucose	insulin	MESH:D005947	105613195	Chemical	Gene	responsiveness|compound|START_ENTITY responsiveness|nmod|responsiveness responsiveness|nsubj|effect effect|nmod|supplemental_propionate supplemental_propionate|nmod|END_ENTITY	The effect of supplemental_propionate on insulin responsiveness to glucose and tissue responsiveness to insulin in relation to feeding in sheep .
9616209	0	glucose	67,74	insulin	127,134	glucose	insulin	MESH:D005947	3630	Chemical	Gene	trafficking|nmod|START_ENTITY defects|nmod|trafficking Evidence|nmod|defects transporters|nsubj|Evidence transporters|nmod|cause cause|nmod|resistance resistance|compound|END_ENTITY	Evidence for defects in the trafficking and translocation of GLUT4 glucose transporters in skeletal muscle as a cause of human insulin resistance .
9626150	0	glucose	57,64	insulin	27,34	glucose	insulin	MESH:D005947	3630	Chemical	Gene	uptake|compound|START_ENTITY dependent|nmod|uptake dependent|nsubj|effect effect|nmod|END_ENTITY	The vasodilating effect of insulin is dependent on local glucose uptake : a double blind , placebo-controlled study .
9659817	5	glucose	771,778	insulin	758,765	glucose	insulin	MESH:D005947	3630	Chemical	Gene	challenge|compound|START_ENTITY END_ENTITY|nmod|challenge	After gastrectomy , the predicted response of insulin to a glucose challenge was excessive in normal subjects and those with slightly impaired_glucose_tolerance .
9688888	0	glucose	77,84	insulin	66,73	glucose	insulin	MESH:D005947	3630	Chemical	Gene	production|compound|START_ENTITY Role|nmod|production Role|nmod|effect effect|nmod|END_ENTITY	Role of free fatty_acids and glucagon in the peripheral effect of insulin on glucose production in humans .
9689076	0	glucose	55,62	insulin	25,32	glucose	insulin	MESH:D005947	3630	Chemical	Gene	transcription|nmod|START_ENTITY transcription|nsubj|regulation regulation|nmod|gene gene|compound|END_ENTITY	Short-term regulation of insulin gene transcription by glucose .
969704	0	glucose	70,77	insulin	37,44	glucose	insulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY -LSB-|nmod|test -LSB-|dobj|effect effect|nmod|caffeine caffeine|nmod|level level|compound|END_ENTITY	-LSB- The effect of caffeine on the serum insulin level during intravenous glucose tolerance test in patients with chemical diabetes -RSB- .
9703324	6	glucose	1075,1082	insulin	1043,1050	glucose	Insulin	MESH:D005947	3630	Chemical	Gene	releasable|nmod|START_ENTITY releasable|compound|END_ENTITY	Fractional insulin secretion -LRB- percentage of total cell insulin releasable at 10 mmol/l glucose -RRB- was unchanged in beta-cells overexpressing the wild-type IR compared with the parental beta-cell line .
9709933	0	glucose	10,17	insulin	21,28	glucose	insulin	MESH:D005947	3630	Chemical	Gene	START_ENTITY|nmod|ratio ratio|compound|END_ENTITY	A fasting glucose to insulin ratio is a useful measure of insulin sensitivity in women with polycystic_ovary_syndrome .
9709933	0	glucose	10,17	insulin	58,65	glucose	insulin	MESH:D005947	3630	Chemical	Gene	measure|nsubj|START_ENTITY measure|nmod|sensitivity sensitivity|compound|END_ENTITY	A fasting glucose to insulin ratio is a useful measure of insulin sensitivity in women with polycystic_ovary_syndrome .
9764732	0	glucose	46,53	insulin	78,85	glucose	insulin	MESH:D005947	3630	Chemical	Gene	load|compound|START_ENTITY size|nmod|load Modulation|nmod|size associated|nsubjpass|Modulation associated|nmod|levels levels|compound|END_ENTITY	Modulation of LDL particle size after an oral glucose load is associated with insulin levels .
976605	1	glucose	101,108	insulin	132,139	glucose	insulin	MESH:D005947	3630	Chemical	Gene	START_ENTITY|nmod|phase phase|nmod|release release|compound|END_ENTITY	Important role of the rise of blood glucose in the second phase of insulin release induced by argiinine .
9801136	0	glucose	20,27	insulin	48,55	glucose	insulin	MESH:D005947	3630	Chemical	Gene	transport|compound|START_ENTITY regulates|nsubj|transport regulates|dobj|sensitivity sensitivity|compound|END_ENTITY	Insulin-independent glucose transport regulates insulin sensitivity .
9833947	0	glucose	126,133	insulin	70,77	glucose	insulin	MESH:D005947	3630	Chemical	Gene	gavage|compound|START_ENTITY secretion|nmod|gavage secretion|compound|END_ENTITY	Transgenic overexpression of human islet amyloid polypeptide inhibits insulin secretion and glucose elimination after gastric glucose gavage in mice .
9843746	0	glucose	32,39	insulin	69,76	glucose	insulin	MESH:D005947	3630	Chemical	Gene	effectiveness|compound|START_ENTITY effectiveness|nmod|presence presence|nmod|response response|compound|END_ENTITY	Overestimation of minimal model glucose effectiveness in presence of insulin response is due to undermodeling .
9861541	4	glucose	538,545	insulin	520,527	glucose	insulin	MESH:D005947	280829(Tax:9913)	Chemical	Gene	administrations|compound|START_ENTITY END_ENTITY|nmod|administrations	The peak increments in plasma insulin after the glucose and butyrate administrations were lower during heat exposure .
9867217	0	glucose	219,226	insulin	154,161	glucose	insulin	MESH:D005947	3630	Chemical	Gene	concentrations|nmod|START_ENTITY transfected|nmod|concentrations transfected|nmod|insulin insulin|appos|glucose_transporter_type_2 glucose_transporter_type_2|dep|secretion secretion|compound|END_ENTITY	Cellular characterization of pituitary_adenoma cell line -LRB- AtT20 cell -RRB- transfected with insulin , glucose_transporter_type_2 -LRB- GLUT2 -RRB- and glucokinase genes : insulin secretion in response to physiological concentrations of glucose .
9867217	0	glucose	219,226	insulin	87,94	glucose	insulin	MESH:D005947	3630	Chemical	Gene	concentrations|nmod|START_ENTITY transfected|nmod|concentrations transfected|nmod|END_ENTITY	Cellular characterization of pituitary_adenoma cell line -LRB- AtT20 cell -RRB- transfected with insulin , glucose_transporter_type_2 -LRB- GLUT2 -RRB- and glucokinase genes : insulin secretion in response to physiological concentrations of glucose .
9872209	0	glucose	85,92	insulin	49,56	glucose	insulin	MESH:D005947	3630	Chemical	Gene	levels|compound|START_ENTITY controlling|dobj|levels lung|acl|controlling lung|nmod|END_ENTITY	The lung as an alternative route of delivery for insulin in controlling postprandial glucose levels in patients with diabetes .
9892228	0	glucose	64,71	insulin	36,43	glucose	insulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY improves|dobj|tolerance improves|nsubj|Restoration Restoration|nmod|rise rise|nmod|levels levels|compound|END_ENTITY	Restoration of early rise in plasma insulin levels improves the glucose tolerance of type 2 diabetic patients .
9923727	4	glucose	556,563	insulin	581,588	glucose	insulin	MESH:D005947	3630	Chemical	Gene	uptake|compound|START_ENTITY determinants|nmod|uptake influencing|dobj|determinants exercise|acl|influencing enhances|nsubj|exercise enhances|dobj|action action|compound|END_ENTITY	Regular exercise , by favourably influencing the intramuscular determinants of glucose uptake , enhances insulin action .
9932219	0	glucose	48,55	insulin	19,26	glucose	insulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY LISPRO|nmod|metabolism LISPRO|nsubj|Effects Effects|nmod|END_ENTITY	Effects of regular insulin or insulin LISPRO on glucose metabolism after an oral glucose load in patients with type_2_diabetes_mellitus .
9932219	0	glucose	81,88	insulin	19,26	glucose	insulin	MESH:D005947	3630	Chemical	Gene	load|compound|START_ENTITY LISPRO|nmod|load LISPRO|nsubj|Effects Effects|nmod|END_ENTITY	Effects of regular insulin or insulin LISPRO on glucose metabolism after an oral glucose load in patients with type_2_diabetes_mellitus .
993351	0	glucose	60,67	insulin	12,19	glucose	insulin	MESH:D005947	483665(Tax:9615)	Chemical	Gene	production|compound|START_ENTITY regulation|nmod|production role|nmod|regulation role|nmod|END_ENTITY	The role of insulin and glucagon in the regulation of basal glucose production in the postabsorptive dog .
17106696	0	glucose	89,96	insulin-induced_gene_1	38,60	glucose	insulin-induced gene 1	MESH:D005947	3638	Chemical	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Human evidence for the involvement of insulin-induced_gene_1 in the regulation of plasma glucose concentration .
10036618	0	glucose	161,168	insulin-like_growth_factor-1	109,137	glucose	insulin-like growth factor-1	MESH:D005947	3479	Chemical	Gene	metabolism|compound|START_ENTITY treatment|nmod|metabolism treatment|amod|END_ENTITY	-LSB- Biological and clinical analyses of the mechanism of growth_retardation and the effect of recombinant human insulin-like_growth_factor-1 -LRB- rhIGF-1 -RRB- treatment on glucose metabolism and growth in leprechaunism with severe insulin_resistant_diabetes -RSB- .
17988556	0	glucose	67,74	insulin-like_growth_factor-1	12,40	glucose	insulin-like growth factor-1	MESH:D005947	3479	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	-LSB- Effects of insulin-like_growth_factor-1 and insulin on modulating glucose metabolism and functions of lung fibroblasts -RSB- .
1601998	0	glucose	43,50	insulin-like_growth_factor-I	11,39	glucose	insulin-like growth factor-I	MESH:D005947	3479	Chemical	Gene	tolerance|compound|START_ENTITY Effects|nmod|tolerance Effects|nmod|END_ENTITY	Effects of insulin-like_growth_factor-I on glucose tolerance , insulin levels , and insulin secretion .
17030015	0	glucose	62,69	insulin-like_growth_factor-I	15,43	glucose	insulin-like growth factor-I	MESH:D005947	3479	Chemical	Gene	control|nmod|START_ENTITY END_ENTITY|nmod|control	Involvement of insulin-like_growth_factor-I in the control of glucose homeostasis .
2164929	0	glucose	31,38	insulin-like_growth_factor_1	66,94	glucose	insulin-like growth factor 1	MESH:D005947	3479	Chemical	Gene	Coupling|nmod|START_ENTITY transport|nsubj|Coupling transport|nmod|receptors receptors|nmod|END_ENTITY	Coupling of insulin-responsive glucose transport to receptors for insulin-like_growth_factor_1 in primary human fibroblasts .
21388950	0	glucose	115,122	insulin-like_growth_factor_1_and_insulin-like_growth_factor-binding_protein_3	16,93	glucose	insulin-like growth factor 1 and insulin-like growth factor-binding protein 3	MESH:D005947	3479;3486	Chemical	Gene	influenced|nmod|START_ENTITY influenced|nsubjpass|Binding Binding|nmod|END_ENTITY	Binding between insulin-like_growth_factor_1_and_insulin-like_growth_factor-binding_protein_3 is not influenced by glucose or 2-deoxy-D-glucose .
10999782	0	glucose	151,158	insulin-like_growth_factor_I	18,46	glucose	insulin-like growth factor I	MESH:D005947	3479	Chemical	Gene	studies|nmod|START_ENTITY effects|dep|studies has|dobj|effects has|nsubj|END_ENTITY	Recombinant human insulin-like_growth_factor_I has significant anabolic effects in adults with growth_hormone_receptor_deficiency : studies on protein , glucose , and lipid metabolism .
12703844	0	glucose	151,158	insulin-like_growth_factor_I	37,65	glucose	insulin-like growth factor I	MESH:D005947	3479	Chemical	Gene	disposal|compound|START_ENTITY relationships|nmod|disposal effects|dep|relationships effects|nmod|training training|nmod|END_ENTITY	The effects of intensive training on insulin-like_growth_factor_I -LRB- IGF-I -RRB- and IGF_binding_proteins_1_and_3 in competitive cyclists : relationships with glucose disposal .
1637311	0	glucose	56,63	insulin-like_growth_factor_I	11,39	glucose	insulin-like growth factor I	MESH:D005947	24482(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY rates|nmod|transport Effects|nmod|rates Effects|nmod|END_ENTITY	Effects of insulin-like_growth_factor_I on the rates of glucose transport and utilization in rat skeletal muscle in vitro .
18841528	0	glucose	34,41	insulin-like_growth_factor_I	112,140	glucose	insulin-like growth factor I	MESH:D005947	3479	Chemical	Gene	START_ENTITY|nmod|signaling signaling|nmod|END_ENTITY	Uniaxial cyclic stretch increases glucose uptake into C2C12 myotubes through a signaling pathway independent of insulin-like_growth_factor_I .
25157747	0	glucose	38,45	insulin-like_growth_factor_I	61,89	glucose	insulin-like growth factor I	MESH:D005947	3479	Chemical	Gene	transporter|compound|START_ENTITY GLUT1|dobj|transporter GLUT1|nmod|END_ENTITY	Regulation of human trophoblast GLUT1 glucose transporter by insulin-like_growth_factor_I -LRB- IGF-I -RRB- .
2651479	0	glucose	49,56	insulin-like_growth_factor_I	17,45	glucose	insulin-like growth factor I	MESH:D005947	24482(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY effects|nmod|metabolism effects|nmod|END_ENTITY	Acute effects of insulin-like_growth_factor_I on glucose and amino_acid metabolism in the awake fasted rat .
8538364	0	glucose	87,94	insulin-like_growth_factor_I	50,78	glucose	insulin-like growth factor I	MESH:D005947	104978413	Chemical	Gene	Enhancement|nmod|START_ENTITY Enhancement|nmod|END_ENTITY	Enhancement and inhibition of mitogenic action of insulin-like_growth_factor_I by high glucose in cultured bovine retinal pericytes .
9049730	0	glucose	37,44	insulin-like_growth_factor_I	79,107	glucose	insulin-like growth factor I	MESH:D005947	24482(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY enhances|dobj|transport enhances|nmod|muscle muscle|acl|stimulated stimulated|nmod|END_ENTITY	Voluntary exercise training enhances glucose transport in muscle stimulated by insulin-like_growth_factor_I .
9435535	0	glucose	43,50	insulin-like_growth_factor_I	11,39	glucose	insulin-like growth factor I	MESH:D005947	24482(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY Effects|nmod|metabolism Effects|nmod|END_ENTITY	Effects of insulin-like_growth_factor_I on glucose metabolism in rats with liver_cirrhosis .
9841495	0	glucose	9,16	insulin-like_growth_factor_I	57,85	glucose	insulin-like growth factor I	MESH:D005947	16000(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|nmod|END_ENTITY	Elevated glucose increases mesangial cell sensitivity to insulin-like_growth_factor_I .
1382411	0	glucose	47,54	insulin-like_growth_factor_II	14,43	glucose	insulin-like growth factor II	MESH:D005947	24483(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY effect|nmod|uptake effect|nmod|END_ENTITY	The effect of insulin-like_growth_factor_II on glucose uptake and metabolism in rat skeletal muscle in vitro .
8010960	0	glucose	15,22	insulin-like_growth_factor_II	33,62	glucose	insulin-like growth factor II	MESH:D005947	3481	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|END_ENTITY	Stimulation of glucose uptake by insulin-like_growth_factor_II in human muscle is not mediated by the insulin-like_growth_factor_II / mannose_6-phosphate receptor .
24904844	0	glucose	56,63	insulin-like_growth_factor_binding_protein-3	8,52	glucose	insulin-like growth factor binding protein-3	MESH:D005947	16009(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY Role|nmod|metabolism Role|nmod|END_ENTITY	Role of insulin-like_growth_factor_binding_protein-3 in glucose and lipid metabolism .
446911	0	glucose	6,13	insulin_and_counterregulatory_hormones	39,77	glucose	insulin and counterregulatory hormones	MESH:D005947	483665(Tax:9615)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|effects effects|nmod|END_ENTITY	Blood glucose regulates the effects of insulin_and_counterregulatory_hormones on glucose production in vivo .
446911	0	glucose	81,88	insulin_and_counterregulatory_hormones	39,77	glucose	insulin and counterregulatory hormones	MESH:D005947	483665(Tax:9615)	Chemical	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	Blood glucose regulates the effects of insulin_and_counterregulatory_hormones on glucose production in vivo .
10212828	0	glucose	41,48	insulin_receptor	4,20	glucose	insulin receptor	MESH:D005947	3643	Chemical	Gene	homeostasis|compound|START_ENTITY link|nmod|homeostasis END_ENTITY|dep|link	The insulin_receptor -- a critical link in glucose homeostasis and insulin action .
10452959	0	glucose	129,136	insulin_receptor	23,39	glucose	insulin receptor	MESH:D005947	16337(Tax:10090)	Chemical	Gene	meal|compound|START_ENTITY vivo|nmod|meal stimulation|nmod|vivo nucleus|nmod|stimulation levels|nmod|nucleus levels|compound|END_ENTITY	Obese mice have higher insulin_receptor levels in the hepatocyte cell nucleus following insulin stimulation in vivo with an oral glucose meal .
10764799	0	glucose	85,92	insulin_receptor	45,61	glucose	insulin receptor	MESH:D005947	3643	Chemical	Gene	down-signaling|nmod|START_ENTITY down-signaling|nsubj|attenuation attenuation|nmod|branch branch|nmod|END_ENTITY	Selective attenuation of metabolic branch of insulin_receptor down-signaling by high glucose in a hepatoma cell line , HepG2 cells .
10816439	0	glucose	102,109	insulin_receptor	27,43	glucose	insulin receptor	MESH:D005947	24954(Tax:10116)	Chemical	Gene	localization|nmod|START_ENTITY localization|nmod|protein protein|compound|END_ENTITY	Perivenous localization of insulin_receptor protein in rat liver , and regulation of its expression by glucose and oxygen in hepatocyte cultures .
11075718	0	glucose	102,109	insulin_receptor	43,59	glucose	insulin receptor	MESH:D005947	3643	Chemical	Gene	transport|compound|START_ENTITY responsiveness|nmod|transport responsiveness|nsubj|Stimulation Stimulation|nmod|D3 D3|nmod|expression expression|compound|END_ENTITY	Stimulation by 1,25-dihydroxyvitamin _ D3 of insulin_receptor expression and insulin responsiveness for glucose transport in U-937 human promonocytic cells .
12933652	0	glucose	49,56	insulin_receptor	145,161	glucose	insulin receptor	MESH:D005947	3643	Chemical	Gene	transport|compound|START_ENTITY stimulates|dobj|transport stimulates|nmod|adipocytes adipocytes|acl|overexpressing overexpressing|nmod|independent independent|nmod|substrates substrates|compound|END_ENTITY	Platelet-derived growth factor -LRB- PDGF -RRB- stimulates glucose transport in 3T3-L1 adipocytes overexpressing PDGF receptor by a pathway independent of insulin_receptor substrates .
12963028	0	glucose	64,71	insulin_receptor	17,33	glucose	insulin receptor	MESH:D005947	3643	Chemical	Gene	levels|compound|START_ENTITY increases|dobj|levels increases|nsubj|Injection Injection|nmod|subunit subunit|amod|alpha alpha|dep|END_ENTITY	Injection of the insulin_receptor alpha subunit increases blood glucose levels in mice .
1340089	0	glucose	131,138	insulin_receptor	95,111	glucose	insulin receptor	MESH:D005947	24954(Tax:10116)	Chemical	Gene	level|compound|START_ENTITY level|compound|END_ENTITY	Impact of a single insulin treatment -LRB- imprinting -RRB- applied during liver regeneration on hepatic insulin_receptor development , blood glucose level and liver function parameters in adult rats .
1494980	0	glucose	20,27	insulin_receptor	45,61	glucose	insulin receptor	MESH:D005947	16337(Tax:10090)	Chemical	Gene	concentration|compound|START_ENTITY concentration|nmod|up-regulation up-regulation|compound|END_ENTITY	Suppression by high glucose concentration of insulin_receptor up-regulation in diaphragm and flexor digitorum brevis muscles from diabetic KK-CAy and streptozotocin-diabetic mice .
15165993	0	glucose	52,59	insulin_receptor	78,94	glucose	insulin receptor	MESH:D005947	24954(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY modulates|dobj|uptake modulates|nmod|END_ENTITY	Cold-induced PGC-1alpha expression modulates muscle glucose uptake through an insulin_receptor / Akt-independent , AMPK-dependent pathway .
1618850	0	glucose	118,125	insulin_receptor	21,37	glucose	insulin receptor	MESH:D005947	3643	Chemical	Gene	transport|compound|START_ENTITY stimulation|nmod|transport sites|nmod|stimulation autophosphorylation|dobj|sites autophosphorylation|nsubj|role role|nmod|END_ENTITY	Differential role of insulin_receptor autophosphorylation sites 1162 and 1163 in the long-term insulin stimulation of glucose transport , glycogenesis , and protein synthesis .
16644916	0	glucose	46,53	insulin_receptor	8,24	glucose	insulin receptor	MESH:D005947	16337(Tax:10090)	Chemical	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Role of insulin_receptor in the regulation of glucose uptake in neonatal hepatocytes .
17953367	0	glucose	124,131	insulin_receptor	28,44	glucose	insulin receptor	MESH:D005947	3643	Chemical	Gene	exposed|nmod|START_ENTITY cell|acl|exposed activity|nmod|cell tyrosine|dobj|activity tyrosine|nsubj|effect effect|nmod|metformin metformin|nmod|protein protein|compound|END_ENTITY	-LSB- The effect of metformin on insulin_receptor protein tyrosine kinase activity of HIT-T15 cell exposed to high concentration glucose and free fatty_acid -RSB- .
18348886	0	glucose	26,33	insulin_receptor	55,71	glucose	insulin receptor	MESH:D005947	3643	Chemical	Gene	uptake|compound|START_ENTITY uptake|acl|enhancing enhancing|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Corosolic_acid stimulates glucose uptake via enhancing insulin_receptor phosphorylation .
1941189	0	glucose	31,38	insulin_receptor	68,84	glucose	insulin receptor	MESH:D005947	24954(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY affects|dobj|metabolism affects|advcl|affecting affecting|dobj|number number|compound|END_ENTITY	Dietary fat saturation affects glucose metabolism without affecting insulin_receptor number and affinity in adipocytes from BHE rats .
19662499	0	glucose	34,41	insulin_receptor	77,93	glucose	insulin receptor	MESH:D005947	3643	Chemical	Gene	uptake|compound|START_ENTITY increases|dobj|uptake increases|nmod|trans-activation trans-activation|nmod|END_ENTITY	Sphingosine_1-phosphate increases glucose uptake through trans-activation of insulin_receptor .
20823693	0	glucose	116,123	insulin_receptor	50,66	glucose	insulin receptor	MESH:D005947	24954(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY transport|amod|END_ENTITY	Blockade of the Renin-Angiotensin system improves insulin_receptor signaling and insulin-stimulated skeletal muscle glucose transport in burn_injury .
21301931	0	glucose	23,30	insulin_receptor	63,79	glucose	insulin receptor	MESH:D005947	24954(Tax:10116)	Chemical	Gene	oxidation|compound|START_ENTITY influence|dobj|oxidation influence|nmod|modulation modulation|nmod|expression expression|compound|END_ENTITY	Sex steroids influence glucose oxidation through modulation of insulin_receptor expression and IRS-1 serine phosphorylation in target tissues of adult male rat .
21324373	0	glucose	137,144	insulin_receptor	31,47	glucose	insulin receptor	MESH:D005947	3643	Chemical	Gene	transport|compound|START_ENTITY expression|appos|transport modulation|nmod|expression Expression|dep|modulation Expression|nmod|END_ENTITY	Expression and function of the insulin_receptor in normal and osteoarthritic human chondrocytes : modulation of anabolic gene expression , glucose transport and GLUT-1 content by insulin .
21952243	0	glucose	63,70	insulin_receptor	117,133	glucose	insulin receptor	MESH:D005947	16337(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY increases|dobj|uptake increases|advcl|augmenting augmenting|dobj|END_ENTITY	Inhibition of the protein tyrosine phosphatase SHP-1 increases glucose uptake in skeletal muscle cells by augmenting insulin_receptor signaling and GLUT4 expression .
22081023	0	glucose	82,89	insulin_receptor	42,58	glucose	insulin receptor	MESH:D005947	16337(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY governs|dep|metabolism governs|amod|END_ENTITY	A hepatocyte_growth_factor receptor -LRB- Met -RRB- - insulin_receptor hybrid governs hepatic glucose metabolism .
22431203	0	glucose	128,135	insulin_receptor	45,61	glucose	insulin receptor	MESH:D005947	16337(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY improvement|nmod|homeostasis elicits|dobj|improvement potentiator|acl:relcl|elicits potentiator|compound|END_ENTITY	The Lyn kinase activator MLR-1023 is a novel insulin_receptor potentiator that elicits a rapid-onset and durable improvement in glucose homeostasis in animal models of type 2 diabetes .
23395167	0	glucose	14,21	insulin_receptor	63,79	glucose	insulin receptor	MESH:D005947	3643	Chemical	Gene	metabolism|compound|START_ENTITY enhances|dobj|metabolism enhances|advcl|promoting promoting|dobj|expression expression|compound|END_ENTITY	LRP6 enhances glucose metabolism by promoting TCF7L2-dependent insulin_receptor expression and IGF receptor stabilization in humans .
23414136	0	glucose	55,62	insulin_receptor	98,114	glucose	insulin receptor	MESH:D005947	16337(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY regulate|dobj|homeostasis regulate|nmod|mice mice|nmod|binding binding|nmod|END_ENTITY	Momordica charantia and its novel polypeptide regulate glucose homeostasis in mice via binding to insulin_receptor .
23592917	0	glucose	77,84	insulin_receptor	8,24	glucose	insulin receptor	MESH:D005947	3643	Chemical	Gene	cultured|nmod|START_ENTITY cultured|nsubj|END_ENTITY	Reduced insulin_receptor signaling in retinal M ller cells cultured in high glucose .
23969187	0	glucose	27,34	insulin_receptor	52,68	glucose	insulin receptor	MESH:D005947	3643	Chemical	Gene	improves|dobj|START_ENTITY improves|nmod|patients patients|nmod|mutations mutations|compound|END_ENTITY	Metreleptin improves blood glucose in patients with insulin_receptor mutations .
24508798	0	glucose	75,82	insulin_receptor	33,49	glucose	insulin receptor	MESH:D005947	3643	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Development Development|nmod|model model|nmod|cleavage cleavage|compound|END_ENTITY	Development of in vitro model of insulin_receptor cleavage induced by high glucose in HepG2 cells .
24568842	0	glucose	63,70	insulin_receptor	131,147	glucose	insulin receptor	MESH:D005947	3643	Chemical	Gene	uptake|compound|START_ENTITY activate|dobj|uptake activate|nmod|domain domain|nmod|END_ENTITY	Human biliverdin reductase-based peptides activate and inhibit glucose uptake through direct interaction with the kinase domain of insulin_receptor .
25144709	0	glucose	75,82	insulin_receptor	152,168	glucose	insulin receptor	MESH:D005947	16337(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY enhances|dobj|uptake enhances|nmod|END_ENTITY	A novel insulin_receptor-binding protein from Momordica charantia enhances glucose uptake and glucose clearance in vitro and in vivo through triggering insulin_receptor signaling pathway .
2543399	0	glucose	24,31	insulin_receptor	50,66	glucose	insulin receptor	MESH:D005947	3643	Chemical	Gene	concentrations|compound|START_ENTITY concentrations|nmod|levels levels|compound|END_ENTITY	Effect of two different glucose concentrations on insulin_receptor mRNA levels in human hepatoma HepG2 cells .
2834414	0	glucose	115,122	insulin_receptor	15,31	glucose	insulin receptor	MESH:D005947	3643	Chemical	Gene	transport|compound|START_ENTITY sensitivity|nmod|transport correlation|nmod|sensitivity Alterations|dep|correlation Alterations|nmod|autophosphorylation autophosphorylation|compound|END_ENTITY	Alterations in insulin_receptor autophosphorylation in insulin resistance : correlation with altered sensitivity to glucose transport and antilipolysis to insulin .
3033648	0	glucose	66,73	insulin_receptor	35,51	glucose	insulin receptor	MESH:D005947	3643	Chemical	Gene	transport|compound|START_ENTITY activate|dobj|transport END_ENTITY|acl:relcl|activate	Monoclonal antibodies to the human insulin_receptor that activate glucose transport but not insulin_receptor kinase activity .
3512551	0	glucose	17,24	insulin_receptor	42,58	glucose	insulin receptor	MESH:D005947	24954(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY Recycling|nmod|transporter adipocytes|advcl|Recycling adipocytes|nsubj|END_ENTITY	Recycling of the glucose transporter , the insulin_receptor , and insulin in rat adipocytes .
3890451	0	glucose	20,27	insulin_receptor	58,74	glucose	insulin receptor	MESH:D005947	24954(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY incorporation|dep|effect incorporation|acl|mediated mediated|nmod|END_ENTITY	Is copper effect on glucose incorporation mediated by the insulin_receptor in rat adipose tissue ?
438322	1	glucose	182,189	insulin_receptor	158,174	glucose	insulin receptor	MESH:D005947	24954(Tax:10116)	Chemical	Gene	system|compound|START_ENTITY END_ENTITY|nmod|system	Possible evidence for a structural relationship of the insulin_receptor to the glucose transport system .
6363438	0	glucose	126,133	insulin_receptor	24,40	glucose	insulin receptor	MESH:D005947	3643	Chemical	Gene	disposal|compound|START_ENTITY curve|nmod|disposal shape|nmod|curve binding|nmod|shape binding|nsubj|Influence Influence|nmod|changes changes|nmod|END_ENTITY	Influence of changes in insulin_receptor binding during insulin infusions on the shape of the insulin dose-response curve for glucose disposal in man .
7039360	0	glucose	59,66	insulin_receptor	12,28	glucose	insulin receptor	MESH:D005947	24954(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY Relation|nmod|transport Relation|nmod|occupancy occupancy|compound|END_ENTITY	Relation of insulin_receptor occupancy and deactivation of glucose transport .
7052124	0	glucose	70,77	insulin_receptor	30,46	glucose	insulin receptor	MESH:D005947	24954(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY relationships|nmod|transport relationships|nmod|END_ENTITY	Kinetic relationships between insulin_receptor binding and effects on glucose transport in isolated rat adipocytes .
7326854	0	glucose	15,22	insulin_receptor	52,68	glucose	insulin receptor	MESH:D005947	3643	Chemical	Gene	tolerance|compound|START_ENTITY Impairment|nmod|tolerance Impairment|nmod|END_ENTITY	-LSB- Impairment of glucose tolerance and involvement of insulin_receptor in obesity of childhood -LRB- author 's transl -RRB- -RSB- .
8123024	0	glucose	100,107	insulin_receptor	20,36	glucose	insulin receptor	MESH:D005947	3643	Chemical	Gene	concentration|compound|START_ENTITY effects|nmod|concentration Regulation|dep|effects Regulation|nmod|RNA RNA|compound|END_ENTITY	Regulation of human insulin_receptor RNA splicing in HepG2 cells : effects of glucocorticoid and low glucose concentration .
8280122	0	glucose	30,37	insulin_receptor	65,81	glucose	insulin receptor	MESH:D005947	24954(Tax:10116)	Chemical	Gene	START_ENTITY|acl|induced induced|dobj|desensitization desensitization|nmod|kinase kinase|compound|END_ENTITY	Pioglitazone ameliorates high glucose induced desensitization of insulin_receptor kinase in Rat 1 fibroblasts in culture .
8419945	0	glucose	14,21	insulin_receptor	67,83	glucose	insulin receptor	MESH:D005947	3643	Chemical	Gene	Activation|nmod|START_ENTITY transport|nsubj|Activation transport|nmod|mutation mutation|nmod|END_ENTITY	Activation of glucose transport by a natural mutation in the human insulin_receptor .
8624116	0	glucose	6,13	insulin_receptor	92,108	glucose	insulin receptor	MESH:D005947	3643	Chemical	Gene	metabolism|compound|START_ENTITY controlled|nsubjpass|metabolism controlled|nmod|amplification amplification|nmod|END_ENTITY	Brain glucose metabolism is controlled by amplification and desensitization of the neuronal insulin_receptor .
8636366	0	glucose	106,113	insulin_receptor	8,24	glucose	insulin receptor	MESH:D005947	706009(Tax:9544)	Chemical	Gene	tolerance|compound|START_ENTITY deterioration|nmod|tolerance associated|nmod|deterioration associated|nsubjpass|acid acid|compound|END_ENTITY	Altered insulin_receptor messenger ribonucleic acid splicing in liver is associated with deterioration of glucose tolerance in the spontaneously obese and diabetic rhesus_monkey : analysis of controversy between monkey and human studies .
8721776	0	glucose	21,28	insulin_receptor	88,104	glucose	insulin receptor	MESH:D005947	3643	Chemical	Gene	transport|compound|START_ENTITY stimulates|dobj|transport stimulates|nmod|muscle muscle|amod|independent independent|nmod|activation activation|compound|END_ENTITY	C-peptide stimulates glucose transport in isolated human skeletal muscle independent of insulin_receptor and tyrosine kinase activation .
8725009	0	glucose	22,29	insulin_receptor	49,65	glucose	insulin receptor	MESH:D005947	24954(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY stimulates|dobj|uptake stimulates|nmod|END_ENTITY	Histone H4 stimulates glucose uptake through the insulin_receptor .
8863182	0	glucose	88,95	insulin_receptor	24,40	glucose	insulin receptor	MESH:D005947	24954(Tax:10116)	Chemical	Gene	GLUT_1|compound|START_ENTITY expression|nmod|GLUT_1 expression|compound|END_ENTITY	Dexamethasone modulates insulin_receptor expression and subcellular distribution of the glucose transporter GLUT_1 in UMR 106-01 , a clonal osteogenic_sarcoma cell line .
9551089	0	glucose	81,88	insulin_receptor	27,43	glucose	insulin receptor	MESH:D005947	3643	Chemical	Gene	transport|compound|START_ENTITY Role|nmod|transport Role|nmod|END_ENTITY	Role of arginine 86 of the insulin_receptor in insulin binding and activation of glucose transport .
9844629	0	glucose	114,121	insulin_receptor	18,34	glucose	insulin receptor	MESH:D005947	16337(Tax:10090)	Chemical	Gene	tolerance|compound|START_ENTITY altering|dobj|tolerance exhibits|advcl|altering exhibits|nsubj|knockout knockout|compound|END_ENTITY	A muscle-specific insulin_receptor knockout exhibits features of the metabolic_syndrome of NIDDM without altering glucose tolerance .
10843189	0	glucose	81,88	insulin_receptor_substrate-1	44,72	glucose	insulin receptor substrate-1	MESH:D005947	3667	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|amod|END_ENTITY	The Gly -- > Arg972 amino_acid polymorphism in insulin_receptor_substrate-1 affects glucose metabolism in skeletal muscle cells .
16037106	0	glucose	123,130	insulin_receptor_substrate-2	71,99	glucose	insulin receptor substrate-2	MESH:D005947	8660	Chemical	Gene	homeostasis|compound|START_ENTITY homeostasis|amod|END_ENTITY	Polymorphisms in the insulin_receptor_substrate-1 -LRB- IRS-1 -RRB- gene and the insulin_receptor_substrate-2 -LRB- IRS-2 -RRB- gene influence glucose homeostasis and body mass index in women with polycystic_ovary_syndrome and non-hyperandrogenic controls .
24462868	0	glucose	23,30	insulin_receptor_substrate_1	95,123	glucose	insulin receptor substrate 1	MESH:D005947	16367(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY enhances|dobj|uptake enhances|nmod|activation activation|nmod|END_ENTITY	Hydroxylamine enhances glucose uptake in C2C12 skeletal muscle cells through the activation of insulin_receptor_substrate_1 .
9252422	0	glucose	186,193	insulin_upstream_factor_1	121,146	glucose	insulin upstream factor 1	MESH:D005947	3651	Chemical	Gene	mediates|nmod|START_ENTITY mediates|dobj|activation activation|nmod|END_ENTITY	The p38/reactivating kinase mitogen-activated protein kinase cascade mediates the activation of the transcription factor insulin_upstream_factor_1 and insulin gene transcription by high glucose in pancreatic beta-cells .
16249450	0	glucose	86,93	interleukin-1	37,50	glucose	interleukin-1	MESH:D005947	3552	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nmod|effects	Is there a role for locally produced interleukin-1 in the deleterious effects of high glucose or the type 2 diabetes milieu to human pancreatic islets ?
23257358	0	glucose	26,33	interleukin-13	48,62	glucose	interleukin-13	MESH:D005947	16163(Tax:10090)	Chemical	Gene	production|compound|START_ENTITY control|nmod|production control|nmod|END_ENTITY	Direct control of hepatic glucose production by interleukin-13 in mice .
24105413	0	glucose	52,59	interleukin-13	18,32	glucose	interleukin-13	MESH:D005947	3596	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	Autocrine role of interleukin-13 on skeletal muscle glucose metabolism in type 2 diabetic patients involves microRNA let-7 .
18001575	0	glucose	93,100	interleukin-1_beta	11,29	glucose	interleukin-1 beta	MESH:D005947	24494(Tax:10116)	Chemical	Gene	conditions|compound|START_ENTITY Effect|nmod|conditions Effect|nmod|cell cell|amod|END_ENTITY	-LSB- Effect of interleukin-1_beta on glutamine_synthetase in rat retinal M ller cell under high glucose conditions -RSB- .
2086453	0	glucose	121,128	interleukin-1_beta	76,94	glucose	interleukin-1 beta	MESH:D005947	3553	Chemical	Gene	concentration|compound|START_ENTITY presence|nmod|concentration exposed|nmod|presence exposed|nmod|END_ENTITY	Metabolism and beta-cell function of rat pancreatic islets exposed to human interleukin-1_beta in the presence of a high glucose concentration .
8405748	0	glucose	21,28	interleukin-1_beta	104,122	glucose	interleukin-1 beta	MESH:D005947	24494(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY islets|nsubj|effects islets|xcomp|pre-exposed pre-exposed|advcl|END_ENTITY	Different effects of glucose and glyburide on insulin secretion in rat pancreatic islets pre-exposed to interleukin-1_beta .
8408238	0	glucose	8,15	interleukin-1_beta	19,37	glucose	interleukin-1 beta	MESH:D005947	3553	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|production production|amod|END_ENTITY	Role of glucose in interleukin-1_beta production by lipopolysaccharide-activated human monocytes .
9174899	0	glucose	5,12	interleukin-1_beta	55,73	glucose	interleukin-1 beta	MESH:D005947	3553	Chemical	Gene	START_ENTITY|nmod|cells cells|amod|END_ENTITY	High glucose and hyperosmolarity increase secretion of interleukin-1_beta in cultured human aortic endothelial cells .
8662965	0	glucose	22,29	interleukin-1beta	118,135	glucose	interleukin-1beta	MESH:D005947	16176(Tax:10090)	Chemical	Gene	concentration|compound|START_ENTITY exposure|nmod|concentration impairs|nsubj|exposure impairs|nmod|END_ENTITY	Long exposure to high glucose concentration impairs the responsive expression of gamma-glutamylcysteine synthetase by interleukin-1beta and tumor_necrosis_factor-alpha in mouse endothelial cells .
9550283	0	glucose	71,78	interleukin-1beta	50,67	glucose	interleukin-1beta	MESH:D005947	24494(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	Interleukin-13 counteracts suppression induced by interleukin-1beta of glucose metabolism but not of insulin secretion in rat pancreatic islets .
18992303	0	glucose	15,22	interleukin-2	88,101	glucose	interleukin-2	MESH:D005947	3558	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Prolonged high glucose suppresses phorbol_12-myristate_13-acetate and ionomycin-induced interleukin-2 mRNA expression in Jurkat cells .
9933027	0	glucose	23,30	interleukin-3	44,57	glucose	interleukin-3	MESH:D005947	16187(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY regulation|nmod|transport regulation|nmod|END_ENTITY	Distinct regulation of glucose transport by interleukin-3 and oncogenes in a murine bone marrow-derived cell line .
11961304	0	glucose	16,23	interleukin-6	27,40	glucose	interleukin-6	MESH:D005947	3569	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|production production|amod|END_ENTITY	Effects of high glucose on interleukin-6 production in human mesangial cells .
12640021	0	glucose	58,65	interleukin-6	6,19	glucose	interleukin-6	MESH:D005947	3569	Chemical	Gene	uptake|compound|START_ENTITY impair|dobj|uptake impair|nsubj|administration administration|amod|END_ENTITY	Acute interleukin-6 administration does not impair muscle glucose uptake or whole-body glucose disposal in healthy humans .
15001458	0	glucose	88,95	interleukin-6	52,65	glucose	interleukin-6	MESH:D005947	16193(Tax:10090)	Chemical	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Modulation of PPARalpha expression and inflammatory interleukin-6 production by chronic glucose increases monocyte/endothelial adhesion .
16308834	0	glucose	53,60	interleukin-6	85,98	glucose	interleukin-6	MESH:D005947	24498(Tax:10116)	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	Glucagon-stimulated but not isoproterenol-stimulated glucose formation inhibition by interleukin-6 in primary cultured rat hepatocytes .
16945991	0	glucose	49,56	interleukin-6	25,38	glucose	interleukin-6	MESH:D005947	3569	Chemical	Gene	metabolism|compound|START_ENTITY specificity|nmod|metabolism specificity|nmod|action action|amod|END_ENTITY	Signaling specificity of interleukin-6 action on glucose and lipid metabolism in skeletal muscle .
17167225	0	glucose	74,81	interleukin-6	106,119	glucose	interleukin-6	MESH:D005947	3569	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	Increased_glucose_uptake and metabolism in mesangial cells overexpressing glucose transporter 1 increases interleukin-6 and vascular_endothelial_growth_factor production : role of AP-1 and HIF-1alpha .
18162526	0	glucose	81,88	interleukin-6	162,175	glucose	interleukin-6	MESH:D005947	3569	Chemical	Gene	amount|nmod|START_ENTITY transporter-4|nsubj|amount transporter-4|nmod|surface surface|nmod|cells cells|nmod|changes changes|nmod|END_ENTITY	The proinflammatory cytokine tumor_necrosis_factor-alpha increases the amount of glucose transporter-4 at the surface of muscle cells independently of changes in interleukin-6 .
18171428	0	glucose	36,43	interleukin-6	8,21	glucose	interleukin-6	MESH:D005947	3569	Chemical	Gene	metabolism|compound|START_ENTITY Role|nmod|metabolism Role|nmod|signalling signalling|amod|END_ENTITY	Role of interleukin-6 signalling in glucose and lipid metabolism .
18523033	0	glucose	48,55	interleukin-6	10,23	glucose	interleukin-6	MESH:D005947	24498(Tax:10116)	Chemical	Gene	tolerance|compound|START_ENTITY enhances|dobj|tolerance enhances|nsubj|administration administration|amod|END_ENTITY	Prolonged interleukin-6 administration enhances glucose tolerance and increases skeletal muscle PPARalpha and UCP2 expression in rats .
19482899	0	glucose	62,69	interleukin-6	14,27	glucose	interleukin-6	MESH:D005947	16193(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY effect|nmod|transport effect|nmod|END_ENTITY	The effect of interleukin-6 and the interleukin-6 receptor on glucose transport in mouse skeletal muscle .
23656570	0	glucose	157,164	interleukin-6	52,65	glucose	interleukin-6	MESH:D005947	3569	Chemical	Gene	mediums|compound|START_ENTITY fibroblasts|nmod|mediums fibroblasts|nsubj|Effect Effect|nmod|therapy therapy|nmod|release release|nmod|END_ENTITY	Effect of low-level laser therapy on the release of interleukin-6 and basic_fibroblast_growth_factor from cultured human skin fibroblasts in normal and high glucose mediums .
23776669	0	glucose	25,32	interleukin-6	63,76	glucose	interleukin-6	MESH:D005947	3569	Chemical	Gene	Oral|nmod|START_ENTITY decreases|nsubj|Oral decreases|xcomp|circulating circulating|dobj|concentrations concentrations|amod|END_ENTITY	Oral but not intravenous glucose acutely decreases circulating interleukin-6 concentrations in overweight individuals .
9398733	0	glucose	61,68	interleukin-6	44,57	glucose	interleukin-6	MESH:D005947	3569	Chemical	Gene	regulation|compound|START_ENTITY effects|nmod|regulation effects|nmod|END_ENTITY	Dose-dependent effects of recombinant human interleukin-6 on glucose regulation .
9165232	0	glucose	5,12	interleukin-8	136,149	glucose	interleukin-8	MESH:D005947	3576	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|dep|role role|nmod|END_ENTITY	High glucose enhances the gene expression of interleukin-8 in human endothelial cells , but not in smooth muscle cells : possible role of interleukin-8 in diabetic_macroangiopathy .
12878449	0	glucose	52,59	interleukin_1alpha	10,28	glucose	interleukin 1alpha	MESH:D005947	24493(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY Effect|nmod|metabolism Effect|nmod|END_ENTITY	Effect of interleukin_1alpha and interleukin_2 over glucose metabolism in isolated uterus of restricted diet rats .
20455202	0	glucose	77,84	laminin_receptor	114,130	glucose	laminin receptor	MESH:D005947	100144340(Tax:9986)	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|END_ENTITY	Green tea epigallocatechin_gallate inhibits insulin stimulation of adipocyte glucose uptake via the 67-kilodalton laminin_receptor and AMP-activated protein kinase pathways .
10094581	0	glucose	118,125	leptin	108,114	glucose	leptin	MESH:D005947	25608(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY END_ENTITY|nmod|uptake	Comparing effects of leptin and insulin on glucose metabolism in skeletal muscle : evidence for an effect of leptin on glucose uptake and decarboxylation .
10094581	0	glucose	118,125	leptin	21,27	glucose	leptin	MESH:D005947	25608(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY leptin|nmod|uptake effect|nmod|leptin evidence|nmod|effect effects|dep|evidence effects|nmod|END_ENTITY	Comparing effects of leptin and insulin on glucose metabolism in skeletal muscle : evidence for an effect of leptin on glucose uptake and decarboxylation .
10094581	0	glucose	43,50	leptin	108,114	glucose	leptin	MESH:D005947	25608(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY effects|nmod|metabolism effects|dep|evidence evidence|nmod|effect effect|nmod|END_ENTITY	Comparing effects of leptin and insulin on glucose metabolism in skeletal muscle : evidence for an effect of leptin on glucose uptake and decarboxylation .
10094581	0	glucose	43,50	leptin	21,27	glucose	leptin	MESH:D005947	25608(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY effects|nmod|metabolism effects|nmod|END_ENTITY	Comparing effects of leptin and insulin on glucose metabolism in skeletal muscle : evidence for an effect of leptin on glucose uptake and decarboxylation .
10218962	0	glucose	55,62	leptin	24,30	glucose	leptin	MESH:D005947	25608(Tax:10116)	Chemical	Gene	utilization|compound|START_ENTITY effects|nmod|utilization effects|nmod|END_ENTITY	Differential effects of leptin in regulation of tissue glucose utilization in vivo .
10334303	0	glucose	70,77	leptin	18,24	glucose	leptin	MESH:D005947	25608(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY increases|dobj|uptake increases|nsubj|Microinjection Microinjection|nmod|END_ENTITY	Microinjection of leptin into the ventromedial hypothalamus increases glucose uptake in peripheral tissues in rats .
10337873	0	glucose	75,82	leptin	8,14	glucose	leptin	MESH:D005947	25608(Tax:10116)	Chemical	Gene	uptake|nsubj|START_ENTITY increases|ccomp|uptake increases|nsubj|administration administration|compound|END_ENTITY	Chronic leptin administration increases insulin-stimulated skeletal muscle glucose uptake and transport .
10490793	0	glucose	107,114	leptin	42,48	glucose	leptin	MESH:D005947	25608(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY changes|nmod|metabolism relationship|nmod|changes Effects|dep|relationship Effects|nmod|tumor_necrosis_factor_alpha tumor_necrosis_factor_alpha|nmod|secretion secretion|amod|END_ENTITY	Effects of tumor_necrosis_factor_alpha on leptin secretion and gene expression : relationship to changes of glucose metabolism in isolated rat adipocytes .
10578212	0	glucose	27,34	leptin	17,23	glucose	leptin	MESH:D005947	25608(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	Acute effects of leptin on glucose metabolism of in situ rat perfused livers and isolated hepatocytes .
10992810	0	glucose	21,28	leptin	44,50	glucose	leptin	MESH:D005947	3952	Chemical	Gene	load|compound|START_ENTITY Effect|nmod|load Effect|nmod|concentration concentration|compound|END_ENTITY	Effect of peritoneal glucose load on plasma leptin concentration in continuous ambulatory peritoneal dialysis patients .
11341758	0	glucose	72,79	leptin	34,40	glucose	leptin	MESH:D005947	16846(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY regulation|nmod|metabolism regulation|nmod|promoter promoter|compound|END_ENTITY	Transcriptional regulation of the leptin promoter by insulin-stimulated glucose metabolism in 3t3-l1 adipocytes .
11775566	0	glucose	62,69	leptin	6,12	glucose	leptin	MESH:D005947	3952	Chemical	Gene	tolerance|compound|START_ENTITY range|nmod|tolerance surgery|nmod|range Serum|nmod|surgery Serum|dobj|levels levels|compound|END_ENTITY	Serum leptin levels after bariatric surgery across a range of glucose tolerance from normal to diabetes .
11781757	0	glucose	9,16	leptin	110,116	glucose	leptin	MESH:D005947	25608(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY augments|nsubj|uptake augments|dobj|excursions excursions|nmod|response response|compound|END_ENTITY	Enhanced glucose uptake into adipose tissue induced by early growth restriction augments excursions in plasma leptin response evoked by changes in insulin status .
12194643	0	glucose	65,72	leptin	19,25	glucose	leptin	MESH:D005947	3952	Chemical	Gene	technique|compound|START_ENTITY assessed|nmod|technique assessed|nsubj|role role|nmod|resistance resistance|compound|END_ENTITY	-LSB- Potential role of leptin and insulin resistance assessed by the glucose clamp technique in coronary_artery_disease -RSB- .
12450621	0	glucose	26,33	leptin	96,102	glucose	leptin	MESH:D005947	100034042(Tax:9796)	Chemical	Gene	START_ENTITY|nmod|concentrations concentrations|compound|END_ENTITY	Effects of dexamethasone , glucose infusion , adrenocorticotropin , and propylthiouracil on plasma leptin concentrations in horses .
12937300	0	glucose	76,83	leptin	23,29	glucose	leptin	MESH:D005947	25608(Tax:10116)	Chemical	Gene	mechanism|amod|START_ENTITY downregulates|nmod|mechanism downregulates|dobj|production production|compound|END_ENTITY	Acidosis downregulates leptin production from cultured adipocytes through a glucose transport-dependent post-transcriptional mechanism .
14655846	0	glucose	65,72	leptin	7,13	glucose	leptin	MESH:D005947	3952	Chemical	Gene	metabolism|compound|START_ENTITY clearance|nmod|metabolism levels|appos|clearance levels|compound|END_ENTITY	Plasma leptin levels , insulin secretion , clearance and action on glucose metabolism in anorexia_nervosa .
14732449	0	glucose	41,48	leptin	8,14	glucose	leptin	MESH:D005947	396832(Tax:9823)	Chemical	Gene	isolated|dobj|START_ENTITY isolated|nsubj|alters alters|compound|END_ENTITY	Porcine leptin alters isolated adipocyte glucose and fatty_acid metabolism .
15650121	0	glucose	101,108	leptin	38,44	glucose	leptin	MESH:D005947	25608(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY role|nmod|metabolism secretion|dep|role secretion|compound|END_ENTITY	Eicosapentaenoic fatty_acid increases leptin secretion from primary cultured rat adipocytes : role of glucose metabolism .
15672109	0	glucose	45,52	leptin	19,25	glucose	leptin	MESH:D005947	25608(Tax:10116)	Chemical	Gene	challenge|compound|START_ENTITY determines|nmod|challenge determines|dobj|responses responses|compound|END_ENTITY	Insulin determines leptin responses during a glucose challenge in fed and fasted rats .
16420334	0	glucose	133,140	leptin	36,42	glucose	leptin	MESH:D005947	280836(Tax:9913)	Chemical	Gene	concentrations|nmod|START_ENTITY effects|nmod|concentrations infusion|dep|effects infusion|nmod|END_ENTITY	Intracerebroventricular infusion of leptin into mature merino rams of different metabolic status : effects on blood concentrations of glucose and reproductive and metabolic hormones .
16436285	0	glucose	31,38	leptin	7,13	glucose	leptin	MESH:D005947	25608(Tax:10116)	Chemical	Gene	tolerance|compound|START_ENTITY END_ENTITY|nmod|tolerance	Plasma leptin response to oral glucose tolerance and fasting/re-feeding tests in rats with fructose-induced metabolic derangements .
17379009	10	glucose	1495,1502	leptin	1533,1539	glucose	leptin	MESH:D005947	3952	Chemical	Gene	and_insulin_sensitivity|compound|START_ENTITY and_insulin_sensitivity|nmod|replacement replacement|compound|END_ENTITY	As shown in patients with GL , patients with FPLD have improvement in triglycerides , fasting glucose , _ and_insulin_sensitivity with leptin replacement .
17496155	0	glucose	88,95	leptin	59,65	glucose	leptin	MESH:D005947	25608(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY involved|nmod|metabolism involved|nmod|induction induction|nmod|END_ENTITY	Sp1-mediated transcription is involved in the induction of leptin by insulin-stimulated glucose metabolism .
18171913	0	glucose	80,87	leptin	30,36	glucose	leptin	MESH:D005947	16846(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY regulate|dobj|homeostasis neurons|xcomp|regulate neurons|nsubj|actions actions|nmod|END_ENTITY	Sexually different actions of leptin in proopiomelanocortin neurons to regulate glucose homeostasis .
18561093	0	glucose	91,98	leptin	6,12	glucose	leptin	MESH:D005947	3952	Chemical	Gene	tolerance|compound|START_ENTITY patients|nmod|tolerance END_ENTITY|nmod|patients	Serum leptin and ghrelin levels in active and inactive acromegalic patients during an oral glucose tolerance test .
18599620	0	glucose	101,108	leptin	61,67	glucose	leptin	MESH:D005947	25608(Tax:10116)	Chemical	Gene	concentrations|compound|START_ENTITY decrease|dobj|concentrations block|advcl|decrease block|dobj|ability ability|nmod|administration administration|compound|END_ENTITY	Guanethidine treatment does not block the ability of central leptin administration to decrease blood glucose concentrations in streptozotocin-induced diabetic rats .
18726828	0	glucose	157,164	leptin	180,186	glucose	leptin	MESH:D005947	3952	Chemical	Gene	homeostasis|compound|START_ENTITY homeostasis|nmod|treatment treatment|amod|END_ENTITY	Deconvolution of insulin secretion , insulin hepatic extraction post-hepatic delivery rates and sensitivity during 24-hour standardized meals : time course of glucose homeostasis in leptin replacement treatment .
19169663	10	glucose	1700,1707	leptin	1684,1690	glucose	leptin	MESH:D005947	16846(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY improved|dobj|metabolism improved|nsubj|END_ENTITY	Pair-feeding experiments demonstrated that leptin improved glucose and lipid metabolism independently of the food intake reduction .
19320933	0	glucose	91,98	leptin	17,23	glucose	leptin	MESH:D005947	3952	Chemical	Gene	tolerance|compound|START_ENTITY associated|nmod|tolerance associated|nsubjpass|END_ENTITY	Increased plasma leptin through l-carnitine supplementation is associated with an enhanced glucose tolerance in healthy ponies .
19681034	0	glucose	9,16	leptin	76,82	glucose	leptin	MESH:D005947	3952	Chemical	Gene	tolerance|compound|START_ENTITY associated|nsubjpass|tolerance associated|nmod|change change|nmod|levels levels|compound|END_ENTITY	Abnormal glucose tolerance is associated with diminished postload change in leptin levels in women .
19752162	0	glucose	107,114	leptin	20,26	glucose	leptin	MESH:D005947	16846(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY injected|nmod|uptake injected|nsubj|effects effects|nmod|END_ENTITY	Distinct effects of leptin and a melanocortin receptor agonist injected into medial hypothalamic nuclei on glucose uptake in peripheral tissues .
20678087	0	glucose	38,45	leptin	7,13	glucose	leptin	MESH:D005947	396832(Tax:9823)	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	Plasma leptin , ghrelin and indexes of glucose and lipid metabolism in relation to the appearance of post-weaning oestrus in Mediterranean obese sows -LRB- Iberian pig -RRB- .
21352506	0	glucose	36,43	leptin	21,27	glucose	leptin	MESH:D005947	16846(Tax:10090)	Chemical	Gene	tolerance|compound|START_ENTITY reduces|dobj|tolerance reduces|nsubj|exposure exposure|nmod|END_ENTITY	Neonatal exposure to leptin reduces glucose tolerance in adult mice .
21873226	0	glucose	64,71	leptin	31,37	glucose	leptin	MESH:D005947	25608(Tax:10116)	Chemical	Gene	fasting|dobj|START_ENTITY normalizes|xcomp|fasting normalizes|nsubj|administration administration|nmod|END_ENTITY	Subcutaneous administration of leptin normalizes fasting plasma glucose in obese_type_2 diabetic_UCD-T2DM rats .
22368147	0	glucose	65,72	leptin	14,20	glucose	leptin	MESH:D005947	3952	Chemical	Gene	concentration|compound|START_ENTITY dependent|nmod|concentration dependent|nsubj|effect effect|nmod|END_ENTITY	The effect of leptin on maturing porcine oocytes is dependent on glucose concentration .
22948759	0	glucose	142,149	leptin	62,68	glucose	leptin	MESH:D005947	3952	Chemical	Gene	status|compound|START_ENTITY irrespective|nmod|status determinant|advmod|irrespective determinant|nmod|END_ENTITY	Maternal pregravid weight is the primary determinant of serum leptin and its metabolic associations in pregnancy , irrespective of gestational glucose tolerance status .
23565491	0	glucose	29,36	leptin	19,25	glucose	leptin	MESH:D005947	3952	Chemical	Gene	metabolism|compound|START_ENTITY role|nmod|metabolism role|nmod|END_ENTITY	Regulatory role of leptin in glucose and lipid metabolism in skeletal muscle .
23823177	0	glucose	57,64	leptin	12,18	glucose	leptin	MESH:D005947	3952	Chemical	Gene	metabolism|compound|START_ENTITY Circulating|nmod|metabolism Circulating|dobj|END_ENTITY	Circulating leptin and adiponectin and their relation to glucose metabolism in children with Crohn 's _ disease and ulcerative_colitis .
24424049	0	glucose	86,93	leptin	76,82	glucose	leptin	MESH:D005947	16846(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY sufficient|nmod|homeostasis sufficient|nmod|actions actions|nmod|END_ENTITY	IGFBP2 is neither sufficient nor necessary for the physiological actions of leptin on glucose homeostasis in male ob/ob mice .
9311777	0	glucose	21,28	leptin	51,57	glucose	leptin	MESH:D005947	16846(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY stimulation|nmod|metabolism stimulation|nmod|mice mice|nmod|treatment treatment|compound|END_ENTITY	Acute stimulation of glucose metabolism in mice by leptin treatment .
9421367	0	glucose	46,53	leptin	36,42	glucose	leptin	MESH:D005947	3952	Chemical	Gene	transport|compound|START_ENTITY Evidence|nmod|transport Evidence|nmod|effect effect|nmod|END_ENTITY	Evidence against a direct effect of leptin on glucose transport in skeletal muscle and adipocytes .
9519720	0	glucose	150,157	leptin	7,13	glucose	leptin	MESH:D005947	3952	Chemical	Gene	tolerance|compound|START_ENTITY women|nmod|tolerance decrease|nmod|women appear|xcomp|decrease appear|nsubj|concentrations concentrations|compound|END_ENTITY	Plasma leptin concentrations do not appear to decrease insulin-mediated glucose disposal or glucose-stimulated insulin secretion in women with normal glucose tolerance .
9519720	0	glucose	72,79	leptin	7,13	glucose	leptin	MESH:D005947	3952	Chemical	Gene	disposal|compound|START_ENTITY decrease|dobj|disposal appear|xcomp|decrease appear|nsubj|concentrations concentrations|compound|END_ENTITY	Plasma leptin concentrations do not appear to decrease insulin-mediated glucose disposal or glucose-stimulated insulin secretion in women with normal glucose tolerance .
9571184	0	glucose	39,46	leptin	29,35	glucose	leptin	MESH:D005947	16846(Tax:10090)	Chemical	Gene	utilization|compound|START_ENTITY effects|nmod|utilization effects|nmod|END_ENTITY	Acute and chronic effects of leptin on glucose utilization in lean mice .
9628268	0	glucose	57,64	leptin	11,17	glucose	leptin	MESH:D005947	25608(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY affect|dobj|metabolism Failure|acl|affect Failure|nmod|END_ENTITY	Failure of leptin to affect basal and insulin-stimulated glucose metabolism of rat skeletal muscle in vitro .
9723892	0	glucose	135,142	leptin	27,33	glucose	leptin	MESH:D005947	16846(Tax:10090)	Chemical	Gene	concentration|compound|START_ENTITY pancreas|nmod|concentration affect|nmod|pancreas END_ENTITY|xcomp|affect	Failure of human and mouse leptin to affect insulin , glucagon and somatostatin secretion by the perfused rat pancreas at physiological glucose concentration .
9760583	6	glucose	1188,1195	leptin	1256,1262	glucose	leptin	MESH:D005947	3952	Chemical	Gene	adjusted|nmod|START_ENTITY associated|advcl|adjusted associated|nmod|END_ENTITY	When these associations were adjusted for BMI , age , glucose , and waist circumference were significantly associated with leptin .
10634806	0	glucose	95,102	lipoprotein_lipase	160,178	glucose	lipoprotein lipase	MESH:D005947	4023	Chemical	Gene	expression|nmod|START_ENTITY regulation|nmod|expression regulation|dep|role role|nmod|receptors receptors|nmod|expression expression|amod|END_ENTITY	Differential regulation of macrophage peroxisome proliferator-activated receptor expression by glucose : role of peroxisome proliferator-activated receptors in lipoprotein_lipase gene expression .
11993791	0	glucose	111,118	lipoprotein_lipase	26,44	glucose	lipoprotein lipase	MESH:D005947	4023	Chemical	Gene	related|nmod|START_ENTITY mutation|acl|related mutation|amod|END_ENTITY	Chylomicronemia caused by lipoprotein_lipase gene mutation related to a hyper-response of insulin secretion to glucose .
1402401	0	glucose	13,20	lipoprotein_lipase	78,96	glucose	lipoprotein lipase	MESH:D005947	4023	Chemical	Gene	Retention|nmod|START_ENTITY impedes|nsubj|Retention impedes|dobj|expression expression|nmod|activity activity|amod|END_ENTITY	Retention of glucose by N-linked oligosaccharide chains impedes expression of lipoprotein_lipase activity : effect of castanospermine .
1497606	0	glucose	91,98	lipoprotein_lipase	14,32	glucose	lipoprotein lipase	MESH:D005947	4023	Chemical	Gene	residues|compound|START_ENTITY trimming|nmod|residues requires|xcomp|trimming requires|nsubj|Activation Activation|nmod|END_ENTITY	Activation of lipoprotein_lipase in cardiac myocytes by glycosylation requires trimming of glucose residues in the endoplasmic reticulum .
19698699	0	glucose	48,55	lipoprotein_lipase	19,37	glucose	lipoprotein lipase	MESH:D005947	24539(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY increases|dobj|uptake increases|nsubj|Down-regulation Down-regulation|nmod|END_ENTITY	Down-regulation of lipoprotein_lipase increases glucose uptake in L6 muscle cells .
20628023	0	glucose	21,28	lipoprotein_lipase	100,118	glucose	lipoprotein lipase	MESH:D005947	4023	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|myoblasts myoblasts|acl|transfected transfected|nmod|END_ENTITY	Fatty_acids increase glucose uptake and metabolism in C2C12 myoblasts stably transfected with human lipoprotein_lipase .
2644281	0	glucose	12,19	lipoprotein_lipase	59,77	glucose	lipoprotein lipase	MESH:D005947	24539(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|regulation regulation|nmod|synthesis synthesis|amod|END_ENTITY	The role of glucose and glycosylation in the regulation of lipoprotein_lipase synthesis and secretion in rat adipocytes .
3666316	0	glucose	36,43	lipoprotein_lipase	14,32	glucose	lipoprotein lipase	MESH:D005947	4023	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of lipoprotein_lipase by glucose in primary cultures of isolated human adipocytes .
9243108	0	glucose	38,45	lipoprotein_lipase	99,117	glucose	lipoprotein lipase	MESH:D005947	4023	Chemical	Gene	disposal|compound|START_ENTITY Relationship|nmod|disposal END_ENTITY|nsubj|Relationship	Relationship between insulin-mediated glucose disposal and regulation of plasma and adipose tissue lipoprotein_lipase .
9519750	0	glucose	22,29	lipoprotein_lipase	44,62	glucose	lipoprotein lipase	MESH:D005947	16956(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nsubj|effect	Stimulatory effect of glucose on macrophage lipoprotein_lipase expression and production .
20823103	0	glucose	5,12	lysyl_oxidase	23,36	glucose	lysyl oxidase	MESH:D005947	24914(Tax:10116)	Chemical	Gene	increases|compound|START_ENTITY END_ENTITY|nsubj|increases	High glucose increases lysyl_oxidase expression and activity in retinal endothelial cells : mechanism for compromised extracellular matrix barrier function .
22966818	0	glucose	5,12	lysyl_oxidase	48,61	glucose	lysyl oxidase	MESH:D005947	4015	Chemical	Gene	induced|nsubj|START_ENTITY induced|dobj|expression expression|nmod|END_ENTITY	High glucose induced differential expression of lysyl_oxidase and its isoform in ARPE-19 cells .
26201105	0	glucose	15,22	mTOR	37,41	glucose	mTOR	MESH:D005947	21977(Tax:10090)	Chemical	Gene	Regulation|nmod|START_ENTITY metabolism|nsubj|Regulation metabolism|nmod|END_ENTITY	-LSB- Regulation of glucose metabolism by mTOR signaling -RSB- .
26201105	0	glucose	15,22	mTOR	37,41	glucose	mTOR	MESH:D005947	21977(Tax:10090)	Chemical	Gene	Regulation|nmod|START_ENTITY metabolism|nsubj|Regulation metabolism|nmod|END_ENTITY	-LSB- Regulation of glucose metabolism by mTOR signaling -RSB- .
23159620	0	glucose	117,124	mTORC1	24,30	glucose	mTORC1	MESH:D005947	382056(Tax:10090)	Chemical	Gene	concentration|compound|START_ENTITY dependence|nmod|concentration inhibition|dep|dependence inhibition|nmod|synthesis synthesis|amod|END_ENTITY	Metformin inhibition of mTORC1 activation , DNA synthesis and proliferation in pancreatic_cancer cells : dependence on glucose concentration and role of AMPK .
23514176	0	glucose	29,36	mTORC1	0,6	glucose	mTORC1	MESH:D005947	382056(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY regulates|dobj|metabolism regulates|nsubj|END_ENTITY	mTORC1 regulates CD8 + T-cell glucose metabolism and function independently of PI3K and PKB .
24275666	0	glucose	121,128	mTORC1	60,66	glucose	mTORC1	MESH:D005947	382056(Tax:10090)	Chemical	Gene	autophagy|compound|START_ENTITY enhancing|dobj|autophagy promotes|advcl|enhancing promotes|nsubj|Hyperactivation Hyperactivation|nmod|target target|nmod|rapamycin rapamycin|appos|END_ENTITY	Hyperactivation of mammalian target of rapamycin complex 1 -LRB- mTORC1 -RRB- promotes breast_cancer progression through enhancing glucose starvation-induced autophagy and Akt signaling .
24806638	0	glucose	43,50	mTORC1	116,122	glucose	mTORC1	MESH:D005947	382056(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|END_ENTITY	Leucine facilitates the insulin-stimulated glucose uptake and insulin signaling in skeletal muscle cells : involving mTORC1 and mTORC2 .
25797045	0	glucose	5,12	mTORC1	47,53	glucose	mTORC1	MESH:D005947	382056(Tax:10090)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|xcomp|microRNA-26a microRNA-26a|xcomp|activate activate|dobj|END_ENTITY	High glucose enhances microRNA-26a to activate mTORC1 for mesangial_cell_hypertrophy and matrix protein expression .
17664181	0	glucose	5,12	macrophage_inflammatory_protein-3_alpha	21,60	glucose	macrophage inflammatory protein-3 alpha	MESH:D005947	6364	Chemical	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	High glucose induces macrophage_inflammatory_protein-3_alpha in renal proximal tubule cells via a transforming_growth_factor-beta_1 dependent mechanism .
10415161	0	glucose	73,80	macrophage_migration_inhibitory_factor	14,52	glucose	macrophage migration inhibitory factor	MESH:D005947	103694877	Chemical	Gene	expression|nmod|START_ENTITY expression|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- expression by glucose and insulin in adipocytes in vitro .
17911626	0	glucose	78,85	macrophage_migration_inhibitory_factor	29,67	glucose	macrophage migration inhibitory factor	MESH:D005947	17319(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY regulates|dobj|metabolism regulates|nsubj|END_ENTITY	The proinflammatory cytokine macrophage_migration_inhibitory_factor regulates glucose metabolism during systemic inflammation .
18612626	0	glucose	54,61	macrophage_migration_inhibitory_factor	12,50	glucose	macrophage migration inhibitory factor	MESH:D005947	4282	Chemical	Gene	metabolism|compound|START_ENTITY role|nmod|metabolism role|nmod|END_ENTITY	The role of macrophage_migration_inhibitory_factor on glucose metabolism and diabetes .
20573157	0	glucose	5,12	macrophage_migration_inhibitory_factor	64,102	glucose	macrophage migration inhibitory factor	MESH:D005947	4282	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|apoptosis apoptosis|nmod|cardiomyocytes cardiomyocytes|nmod|END_ENTITY	High glucose induces apoptosis in AC16 human cardiomyocytes via macrophage_migration_inhibitory_factor and c-Jun_N-terminal_kinase .
11423724	0	glucose	5,12	matrix_metalloproteinase-2	23,49	glucose	matrix metalloproteinase-2	MESH:D005947	81686(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|activity activity|amod|END_ENTITY	High glucose decreases matrix_metalloproteinase-2 activity in rat mesangial cells via transforming_growth_factor-beta1 .
20021964	0	glucose	6,13	matrix_metalloproteinase-2	51,77	glucose	matrix metalloproteinase-2	MESH:D005947	4313	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- High glucose and tea polyphenols on expression of matrix_metalloproteinase-2 and extracellular_matrix_metalloproteinase_inducer in human umbilical vein endothelial cells -RSB- .
23159449	0	glucose	58,65	melanocortin-4_receptors	82,106	glucose	melanocortin-4 receptors	MESH:D005947	17202(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY effects|nmod|homeostasis effects|nmod|END_ENTITY	Weight-independent effects of roux-en-Y gastric bypass on glucose homeostasis via melanocortin-4_receptors in mice and humans .
24710643	0	glucose	51,58	melatonin_receptor_1B	11,32	glucose	melatonin receptor 1B	MESH:D005947	4544	Chemical	Gene	variation|nmod|START_ENTITY variation|amod|END_ENTITY	Effects of melatonin_receptor_1B gene variation on glucose control in population from Bosnia and Herzegovina .
24124917	0	glucose	40,47	miR-106a	10,18	glucose	miR-106a	MESH:D005947	406899	Chemical	Gene	inhibits|dobj|START_ENTITY inhibits|dep|END_ENTITY	Decreased miR-106a inhibits glioma cell glucose uptake and proliferation by targeting SLC2A3 in GBM .
26744903	4	glucose	836,843	mice	874,878	glucose	Atg7	MESH:D005947	74244(Tax:10090)	Chemical	Gene	loading|compound|START_ENTITY loading|nmod|END_ENTITY	Vildagliptin treatment improved glucose_intolerance and hypoinsulinemia ; however , it failed to suppress serum glucagon levels after glucose loading in the Atg7 -LRB- b cell -RRB- mice .
12083786	0	glucose	47,54	mif	4,7	glucose	mif	MESH:D005947	4282	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|gene gene|compound|END_ENTITY	The mif gene is transcriptionally regulated by glucose in insulin-secreting cells .
12416806	0	glucose	21,28	milk	39,43	glucose	milk	MESH:D005947	100532204	Chemical	Gene	infusion|nmod|START_ENTITY decreases|nsubj|infusion decreases|dobj|production production|compound|END_ENTITY	Duodenal infusion of glucose decreases milk fat production in grass silage-fed dairy cows .
17955897	0	glucose	17,24	mink	42,46	glucose	mink	MESH:D005947	50488	Chemical	Gene	levels|compound|START_ENTITY levels|nmod|END_ENTITY	Monitoring blood glucose levels in female mink during the reproductive cycle : 1 .
25312648	0	glucose	77,84	mitogen-activated_protein_kinase_phosphatase_1	8,54	glucose	mitogen-activated protein kinase phosphatase 1	MESH:D005947	19252(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY regulates|dobj|metabolism regulates|nsubj|END_ENTITY	Hepatic mitogen-activated_protein_kinase_phosphatase_1 selectively regulates glucose metabolism and energy homeostasis .
11287779	0	glucose	15,22	monocyte_chemoattractant_protein-1	57,91	glucose	monocyte chemoattractant protein-1	MESH:D005947	6347	Chemical	Gene	concentration|compound|START_ENTITY concentration|nmod|synthesis synthesis|nmod|cells cells|amod|END_ENTITY	Effect of high glucose concentration on the synthesis of monocyte_chemoattractant_protein-1 in human peritoneal mesothelial cells : involvement of protein kinase C. Human peritoneal mesothelial cells -LRB- HMC -RRB- contribute to the activation and control of inflammatory processes in the peritoneum by their potential to produce various inflammatory mediators .
15207092	0	glucose	118,125	monocyte_chemoattractant_protein-1	15,49	glucose	monocyte chemoattractant protein-1	MESH:D005947	6347	Chemical	Gene	-RSB-|compound|START_ENTITY concentration|nmod|-RSB- stimulated|nmod|concentration stimulated|nsubj|Expression Expression|nmod|cells cells|amod|END_ENTITY	-LSB- Expression of monocyte_chemoattractant_protein-1 in glomerular endothelial cells stimulated by high concentration of glucose -RSB- .
16600694	0	glucose	104,111	monocyte_chemoattractant_protein-1	42,76	glucose	monocyte chemoattractant protein-1	MESH:D005947	6347	Chemical	Gene	concentration|compound|START_ENTITY induced|nmod|concentration expression|acl|induced expression|amod|END_ENTITY	Aspirin and PPAR-alpha activators inhibit monocyte_chemoattractant_protein-1 expression induced by high glucose concentration in human endothelial cells .
18167242	0	glucose	123,130	monocyte_chemoattractant_protein-1	48,82	glucose	monocyte chemoattractant protein-1	MESH:D005947	6347	Chemical	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	-LSB- Influence of atorvastatin on the expression of monocyte_chemoattractant_protein-1 in peritoneal mesothelial cells by high glucose -RSB- .
20580782	0	glucose	121,128	myeloperoxidase	7,22	glucose	myeloperoxidase	MESH:D005947	4353	Chemical	Gene	metabolism|compound|START_ENTITY associated|nmod|metabolism associated|nsubjpass|END_ENTITY	Plasma myeloperoxidase is inversely associated with endothelium-dependent vasodilation in elderly subjects with abnormal glucose metabolism .
17987120	0	glucose	52,59	myotonic_dystrophy_protein_kinase	8,41	glucose	myotonic dystrophy protein kinase	MESH:D005947	13400(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY Role|nmod|homeostasis Role|nmod|END_ENTITY	Role of myotonic_dystrophy_protein_kinase -LRB- DMPK -RRB- in glucose homeostasis and muscle insulin action .
19204094	0	glucose	54,61	nerve_growth_factor	136,155	glucose	nerve growth factor	MESH:D005947	4803	Chemical	Gene	depend|nmod|START_ENTITY depend|dobj|-2 -2|amod|alpha alpha|xcomp|inhibit inhibit|dobj|death death|acl|caused caused|nmod|deprivation deprivation|amod|END_ENTITY	Prolyl hydroxylase inhibitors depend on extracellular glucose and hypoxia-inducible_factor _ -LRB- HIF -RRB- -2 alpha to inhibit cell death caused by nerve_growth_factor -LRB- NGF -RRB- deprivation : evidence that HIF-2alpha has a role in NGF-promoted survival of sympathetic neurons .
3016173	0	glucose	33,40	nerve_growth_factor	10,29	glucose	nerve growth factor	MESH:D005947	310738(Tax:10116)	Chemical	Gene	utilization|compound|START_ENTITY Effect|nmod|utilization Effect|nmod|END_ENTITY	Effect of nerve_growth_factor on glucose utilization and nucleotide content of pheochromocytoma cells -LRB- clone PC12 -RRB- .
26335059	0	glucose	9,16	neurofibromatosis_type_1	43,67	glucose	neurofibromatosis type 1	MESH:D005947	4763	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|nmod|END_ENTITY	Cerebral glucose metabolism in adults with neurofibromatosis_type_1 .
7798976	0	glucose	9,16	neurofibromatosis_type_1	31,55	glucose	neurofibromatosis type 1	MESH:D005947	4763	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|nmod|END_ENTITY	Cerebral glucose metabolism in neurofibromatosis_type_1 assessed with -LSB- 18F -RSB- -2 - fluoro-2-deoxy-D-glucose and PET .
18234742	0	glucose	57,64	neuropeptide_Y	30,44	glucose	neuropeptide Y	MESH:D005947	475257(Tax:9615)	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|amod|END_ENTITY	Intraportal administration of neuropeptide_Y and hepatic glucose metabolism .
11090931	0	glucose	64,71	neurotensin	34,45	glucose	neurotensin	MESH:D005947	299757(Tax:10116)	Chemical	Gene	utilization|compound|START_ENTITY Effects|nmod|utilization Effects|nmod|END_ENTITY	Effects of intra-VTA injection of neurotensin on local cerebral glucose utilization in freely moving rats .
2333972	0	glucose	43,50	neurotensin	10,21	glucose	neurotensin	MESH:D005947	299757(Tax:10116)	Chemical	Gene	utilization|compound|START_ENTITY Effect|nmod|utilization Effect|nmod|END_ENTITY	Effect of neurotensin on regional cerebral glucose utilization in cold water-restrained rats .
25146190	0	glucose	89,96	nicotinamide_phosphoribosyltransferase	17,55	glucose	nicotinamide phosphoribosyltransferase	MESH:D005947	10135	Chemical	Gene	restriction|compound|START_ENTITY END_ENTITY|nmod|restriction	Up-regulation of nicotinamide_phosphoribosyltransferase and increase of NAD -LRB- + -RRB- levels by glucose restriction extend replicative lifespan of human fibroblast Hs68 cells .
25967970	0	glucose	64,71	nrf2	86,90	glucose	nrf2	MESH:D005947	18024(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nmod|END_ENTITY	Cinnamaldehyde prevents endothelial_dysfunction induced by high glucose by activating nrf2 .
24791887	0	glucose	102,109	nuclear_factor-kB	19,36	glucose	nuclear factor-kB	MESH:D005947	309165(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY activation|acl|induced activation|amod|END_ENTITY	Metformin inhibits nuclear_factor-kB activation and inflammatory cytokines expression induced by high glucose via adenosine_monophosphate-activated protein kinase activation in rat glomerular mesangial cells in vitro .
15989634	5	glucose	757,764	obesity	780,787	glucose	insulin	MESH:D005947	3630	Chemical	Gene	levels|compound|START_ENTITY levels|nmod|END_ENTITY	Thiazolidinediones are ligands for a specific subtype of the peroxisome_proliferator_activated_receptor -LRB- PPAR -RRB- , and decrease plasma glucose levels in both obesity and NIDDM , while at the same time reducing circulating insulin and free fatty_acid levels .
20038793	0	glucose	42,49	osteocalcin	84,95	glucose	osteocalcin	MESH:D005947	12097(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY regulates|dobj|homeostasis regulates|nmod|regulation regulation|nmod|END_ENTITY	FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice .
21550430	0	glucose	47,54	osteocalcin	27,38	glucose	osteocalcin	MESH:D005947	12097(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY improve|dobj|metabolism improve|nsubj|injections injections|nmod|END_ENTITY	Intermittent injections of osteocalcin improve glucose metabolism and prevent type 2 diabetes in mice .
22147278	0	glucose	19,26	osteocalcin	51,62	glucose	osteocalcin	MESH:D005947	12097(Tax:10090)	Chemical	Gene	tolerance|compound|START_ENTITY effect|nmod|tolerance test|nsubj|effect test|nmod|END_ENTITY	The effect of oral glucose tolerance test on serum osteocalcin and bone turnover markers in young adults .
22595150	0	glucose	61,68	osteocalcin	110,121	glucose	osteocalcin	MESH:D005947	81613(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nmod|END_ENTITY	1,25 -LRB- OH -RRB- 2D3 inhibits the deleterious effects induced by high glucose on osteoblasts through undercarboxylated osteocalcin and insulin signaling .
24521696	0	glucose	43,50	osteocalcin	16,27	glucose	osteocalcin	MESH:D005947	632	Chemical	Gene	metabolism|compound|START_ENTITY relation|nmod|metabolism END_ENTITY|nmod|relation	Serum levels of osteocalcin in relation to glucose metabolism and carotid_atherosclerosis in Chinese middle-aged and elderly male adults : the Shanghai Changfeng Study .
24642469	0	glucose	53,60	osteocalcin	87,98	glucose	osteocalcin	MESH:D005947	12097(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY homeostasis|nmod|activation activation|compound|END_ENTITY	Bone-specific insulin resistance disrupts whole-body glucose homeostasis via decreased osteocalcin activation .
25230237	0	glucose	44,51	osteocalcin	23,34	glucose	osteocalcin	MESH:D005947	12097(Tax:10090)	Chemical	Gene	utilization|compound|START_ENTITY improves|dobj|utilization improves|nsubj|administration administration|nmod|END_ENTITY	Oral administration of osteocalcin improves glucose utilization by stimulating glucagon-like_peptide-1 secretion .
10865863	0	glucose	43,50	osteopontin	23,34	glucose	osteopontin	MESH:D005947	6696	Chemical	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Enhanced expression of osteopontin by high glucose .
22844418	0	glucose	69,76	osteopontin	28,39	glucose	osteopontin	MESH:D005947	6696	Chemical	Gene	metabolism|compound|START_ENTITY associated|nmod|metabolism associated|nsubjpass|CTX CTX|nmod|END_ENTITY	CTX -LRB- crosslaps -RRB- rather than osteopontin is associated with disturbed glucose metabolism in gestational_diabetes .
22363694	0	glucose	5,12	p-glycoprotein	50,64	glucose	p-glycoprotein	MESH:D005947	5243	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|nmod|END_ENTITY	High glucose decreases expression and activity of p-glycoprotein in cultured human retinal pigment epithelium possibly through iNOS induction .
25471065	0	glucose	43,50	p110a	24,29	glucose	p110a	MESH:D005947	18706(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY END_ENTITY|dobj|homeostasis	Hepatic miR-378 targets p110a and controls glucose and lipid homeostasis by modulating hepatic insulin signalling .
8063767	0	glucose	37,44	p21ras	8,14	glucose	p21ras	MESH:D005947	15461(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|nmod|transport	Role of p21ras in insulin-stimulated glucose transport in 3T3-L1 adipocytes .
9321907	0	glucose	5,12	p27Kip1	38,45	glucose	p27Kip1	MESH:D005947	12576(Tax:10090)	Chemical	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	High glucose stimulates expression of p27Kip1 in cultured mouse mesangial cells : relationship to hypertrophy .
10187787	0	glucose	81,88	p38	16,19	glucose	p38	MESH:D005947	1432	Chemical	Gene	transport|compound|START_ENTITY prevents|dobj|transport prevents|nsubj|inhibitor inhibitor|nmod|kinase kinase|amod|END_ENTITY	An inhibitor of p38 mitogen-activated protein kinase prevents insulin-stimulated glucose transport but not glucose transporter translocation in 3T3-L1 adipocytes and L6 myotubes .
10644515	0	glucose	5,12	p38	76,79	glucose	p38	MESH:D005947	81649(Tax:10116)	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|advcl|blocking blocking|dobj|iNOS iNOS|nmod|activation activation|amod|END_ENTITY	High glucose and insulin inhibit VSMC MKP-1 expression by blocking iNOS via p38 MAPK activation .
10766828	0	glucose	25,32	p38	55,58	glucose	p38	MESH:D005947	81649(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY Preconditioning|dobj|uptake mediated|csubjpass|Preconditioning mediated|nmod|kinase kinase|amod|END_ENTITY	Preconditioning enhanced glucose uptake is mediated by p38 MAP kinase not by phosphatidylinositol 3-kinase .
11078445	0	glucose	154,161	p38	14,17	glucose	p38	MESH:D005947	81649(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY stimulation|nmod|transport role|nmod|stimulation Activation|dep|role Activation|nmod|protein protein|amod|END_ENTITY	Activation of p38 mitogen-activated protein kinase alpha and beta by insulin and contraction in rat skeletal muscle : potential role in the stimulation of glucose transport .
11532081	0	glucose	50,57	p38	85,88	glucose	p38	MESH:D005947	1432	Chemical	Gene	environments|compound|START_ENTITY cells|nmod|environments exposure|nmod|cells activates|nsubj|exposure activates|dobj|MAPK MAPK|amod|END_ENTITY	Chronic exposure of human mesangial cells to high glucose environments activates the p38 MAPK pathway .
12393894	0	glucose	105,112	p38	20,23	glucose	p38	MESH:D005947	1432	Chemical	Gene	uptake|compound|START_ENTITY reduce|dobj|uptake reduce|nsubj|mutant mutant|amod|END_ENTITY	A dominant-negative p38 MAPK mutant and novel selective inhibitors of p38 MAPK reduce insulin-stimulated glucose uptake in 3T3-L1 adipocytes without affecting GLUT4 translocation .
12631076	0	glucose	5,12	p38	27,30	glucose	p38	MESH:D005947	1432	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|pathway pathway|amod|END_ENTITY	High glucose activates the p38 MAPK pathway in cultured human peritoneal mesothelial cells .
12732205	0	glucose	5,12	p38	46,49	glucose	p38	MESH:D005947	1432	Chemical	Gene	accelerates|nsubj|START_ENTITY accelerates|dobj|production production|nmod|MAPK MAPK|amod|END_ENTITY	High glucose accelerates MCP-1 production via p38 MAPK in vascular endothelial cells .
15364617	0	glucose	14,21	p38	66,69	glucose	p38	MESH:D005947	81649(Tax:10116)	Chemical	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Regulation of glucose transporter expression in cardiac myocytes : p38 MAPK is a strong inducer of GLUT4 .
15665038	0	glucose	68,75	p38	4,7	glucose	p38	MESH:D005947	1432	Chemical	Gene	turnover|compound|START_ENTITY reduces|dobj|turnover reduces|nsubj|SB203580 SB203580|amod|END_ENTITY	The p38 mitogen-activated protein kinase inhibitor SB203580 reduces glucose turnover by the glucose_transporter-4 of 3T3-L1 adipocytes in the insulin-stimulated state .
15886223	0	glucose	76,83	p38	117,120	glucose	p38	MESH:D005947	81649(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY inhibits|dobj|uptake inhibits|nmod|pathways pathways|compound|END_ENTITY	Oleylethanolamide impairs glucose tolerance and inhibits insulin-stimulated glucose uptake in rat adipocytes through p38 and JNK MAPK pathways .
15988698	0	glucose	65,72	p38	30,33	glucose	p38	MESH:D005947	1432	Chemical	Gene	results|nmod|START_ENTITY results|amod|END_ENTITY	Pharmacological inhibition of p38 MAP kinase results in improved glucose uptake in insulin-resistant 3T3-L1 adipocytes .
16249440	0	glucose	19,26	p38	51,54	glucose	p38	MESH:D005947	26416(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY require|nsubj|uptake require|dobj|kinase kinase|amod|END_ENTITY	Insulin-stimulated glucose uptake does not require p38 mitogen-activated protein kinase in adipose tissue or skeletal muscle .
17344580	6	glucose	987,994	p38	842,845	glucose	p38	MESH:D005947	1432	Chemical	Gene	uptake|compound|START_ENTITY p38|nmod|uptake role|nmod|p38 remains|nsubj|role definitive|advcl|remains definitive|nsubj|role role|nmod|END_ENTITY	A fundamental role for p38 in the differentiation of skeletal muscles and mitochondrial biogenesis in skeletal muscles is rather definitive although the role of p38 in glucose uptake of skeletal muscles remains controversial .
17496214	0	glucose	130,137	p38	14,17	glucose	p38	MESH:D005947	81649(Tax:10116)	Chemical	Gene	utilization|compound|START_ENTITY altering|dobj|utilization stressed|advcl|altering hearts|acl|stressed restores|nmod|hearts restores|nsubj|Inhibition Inhibition|nmod|MAPK MAPK|amod|END_ENTITY	Inhibition of p38 MAPK and AMPK restores adenosine-induced cardioprotection in hearts stressed by antecedent ischemia by altering glucose utilization .
18158645	0	glucose	61,68	p38	18,21	glucose	p38	MESH:D005947	81649(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY activation|nmod|transport MAPK|nmod|activation MAPK|nsubj|role role|nmod|END_ENTITY	Essential role of p38 MAPK for activation of skeletal muscle glucose transport by lithium .
19393651	0	glucose	98,105	p38	18,21	glucose	p38	MESH:D005947	1432	Chemical	Gene	conditions|compound|START_ENTITY death|nmod|conditions role|dep|death role|nmod|MAPK MAPK|amod|END_ENTITY	Essential role of p38 MAPK in caspase-independent , iPLA -LRB- 2 -RRB- - dependent cell death under hypoxia/low glucose conditions .
21712532	0	glucose	68,75	p38	40,43	glucose	p38	MESH:D005947	81649(Tax:10116)	Chemical	Gene	supports|nmod|START_ENTITY supports|dobj|activation activation|amod|END_ENTITY	O-linked b-N-acetylglucosamine supports p38 MAPK activation by high glucose in glomerular mesangial cells .
25760137	0	glucose	26,33	p38	113,116	glucose	p38	MESH:D005947	81649(Tax:10116)	Chemical	Gene	START_ENTITY|acl|mediated mediated|nmod|modulation modulation|nmod|expression expression|amod|END_ENTITY	Metformin alleviates high glucose - mediated oxidative stress in rat glomerular mesangial cells by modulation of p38 mitogen-activated protein kinase expression in vitro .
25835326	0	glucose	85,92	p38	14,17	glucose	p38	MESH:D005947	1432	Chemical	Gene	depends|nmod|START_ENTITY depends|nsubj|Activation Activation|nmod|END_ENTITY	Activation of p38 in C2C12 myotubes following ATP depletion depends on extracellular glucose .
9603971	4	glucose	677,684	p38	742,745	glucose	p38	MESH:D005947	1432	Chemical	Gene	treatment|compound|START_ENTITY activated|nsubj|treatment activated|dobj|phosphorylation phosphorylation|nmod|kinase kinase|amod|END_ENTITY	High glucose treatment activated the tyrosine phosphorylation of both p38 kinase and JNK in a dose - and time-dependent fashion .
18391940	0	glucose	14,21	p53	0,3	glucose	p53	MESH:D005947	7157	Chemical	Gene	metabolism|compound|START_ENTITY regulates|dobj|metabolism regulates|nsubj|END_ENTITY	p53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation .
20061129	0	glucose	19,26	p53	12,15	glucose	p53	MESH:D005947	7157	Chemical	Gene	metabolism|compound|START_ENTITY role|nmod|metabolism role|nmod|END_ENTITY	The role of p53 in glucose metabolism .
21287141	0	glucose	46,53	p53	62,65	glucose	p53	MESH:D005947	7157	Chemical	Gene	Glucose_oscillations|appos|START_ENTITY induce|nsubj|Glucose_oscillations induce|dobj|activation activation|compound|END_ENTITY	Glucose_oscillations , more than constant high glucose , induce p53 activation and a metabolic memory in human endothelial cells .
21832879	0	glucose	111,118	p53	54,57	glucose	p53	MESH:D005947	7157	Chemical	Gene	depletion|compound|START_ENTITY promotes|nmod|depletion END_ENTITY|acl:relcl|promotes	Metabolic utilization of exogenous pyruvate by mutant p53 -LRB- R175H -RRB- human melanoma cells promotes survival under glucose depletion .
21930938	0	glucose	55,62	p53	10,13	glucose	p53	MESH:D005947	22060(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY mediates|nmod|metabolism mediates|nsubj|Parkin Parkin|appos|gene gene|compound|END_ENTITY	Parkin , a p53 target gene , mediates the role of p53 in glucose metabolism and the Warburg effect .
21930938	0	glucose	55,62	p53	48,51	glucose	p53	MESH:D005947	22060(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY mediates|nmod|metabolism mediates|dobj|role role|nmod|END_ENTITY	Parkin , a p53 target gene , mediates the role of p53 in glucose metabolism and the Warburg effect .
22248668	0	glucose	14,21	p53	36,39	glucose	p53	MESH:D005947	7157	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|nmod|END_ENTITY	Regulation of glucose metabolism by p53 : emerging new roles for the tumor suppressor .
23151455	0	glucose	48,55	p53	33,36	glucose	p53	MESH:D005947	7157	Chemical	Gene	restriction|compound|START_ENTITY levels|nmod|restriction levels|compound|END_ENTITY	Dietary downregulation of mutant p53 levels via glucose restriction : mechanisms and implications for tumor therapy .
23657598	0	glucose	5,12	p53	35,38	glucose	p53	MESH:D005947	7157	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|compound|END_ENTITY	High glucose induces mitochondrial p53 phosphorylation by p38 MAPK in pancreatic RINm5F cells .
23796712	0	glucose	14,21	p53	0,3	glucose	p53	MESH:D005947	7157	Chemical	Gene	metabolism|compound|START_ENTITY regulates|dobj|metabolism regulates|nsubj|END_ENTITY	p53 regulates glucose metabolism by miR-34a .
24275138	0	glucose	77,84	p53	138,141	glucose	p53	MESH:D005947	7157	Chemical	Gene	preferentially|compound|START_ENTITY resistance|nmod|preferentially counteract|dobj|resistance counteract|nmod|END_ENTITY	Hypoxia and hypoxia mimetic cooperate to counteract tumor cell resistance to glucose starvation preferentially in tumor cells with mutant p53 .
24275138	6	glucose	1226,1233	p53	1206,1209	glucose	p53	MESH:D005947	7157	Chemical	Gene	status|nmod|START_ENTITY status|compound|END_ENTITY	No significant decrease in metabolic activity was evidenced in C8161 melanoma irrespective of p53 status in 2.5 mM glucose after 48h of physical hypoxia .
25064493	0	glucose	134,141	p53	38,41	glucose	p53	MESH:D005947	7157	Chemical	Gene	uptake|compound|START_ENTITY suppress|dobj|uptake increases|parataxis|suppress increases|dobj|levels levels|compound|END_ENTITY	Indoleamine_2 ,3 - dioxygenase increases p53 levels in alloreactive human T cells , and both indoleamine_2 ,3 - dioxygenase and p53 suppress glucose uptake , glycolysis and proliferation .
19701591	0	glucose	67,74	p58	55,58	glucose	p58	MESH:D005947	984	Chemical	Gene	-RSB-|compound|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- Molecular mechanism of beta cell apoptosis induced by p58 in high glucose medium -RSB- .
10926833	0	glucose	122,129	p62	97,100	glucose	p62	MESH:D005947	117268(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY END_ENTITY|nmod|concentration	Responsiveness of the state of O-linked N-acetylglucosamine modification of nuclear pore protein p62 to the extracellular glucose concentration .
1444649	0	glucose	40,47	pancreatic_polypeptide	14,36	glucose	pancreatic polypeptide	MESH:D005947	490944(Tax:9615)	Chemical	Gene	disposal|compound|START_ENTITY effect|nmod|disposal effect|nmod|END_ENTITY	The effect of pancreatic_polypeptide on glucose disposal after surgical alterations of the pancreas .
2191457	0	glucose	49,56	pancreatic_polypeptide	14,36	glucose	pancreatic polypeptide	MESH:D005947	5539	Chemical	Gene	tolerance|compound|START_ENTITY infusion|nmod|tolerance infusion|amod|END_ENTITY	The effect of pancreatic_polypeptide infusion on glucose tolerance and insulin response in longitudinally studied pancreatitis-induced diabetes .
3041640	0	glucose	21,28	pancreatic_polypeptide	70,92	glucose	pancreatic polypeptide	MESH:D005947	5539	Chemical	Gene	production|compound|START_ENTITY Reversal|nmod|production Reversal|nmod|administration administration|amod|END_ENTITY	Reversal of abnormal glucose production after pancreatic resection by pancreatic_polypeptide administration in man .
6275494	0	glucose	92,99	pancreatic_polypeptide	40,62	glucose	pancreatic polypeptide	MESH:D005947	5539	Chemical	Gene	modulation|nmod|START_ENTITY modulation|nmod|release release|nmod|END_ENTITY	Adrenergic modulation of the release of pancreatic_polypeptide after intraduodenal and oral glucose in man .
7019986	0	glucose	80,87	pancreatic_polypeptide	30,52	glucose	pancreatic polypeptide	MESH:D005947	490944(Tax:9615)	Chemical	Gene	administration|compound|START_ENTITY Effect|nmod|administration Effect|nmod|response response|amod|END_ENTITY	Effect of truncal vagotomy on pancreatic_polypeptide response after intravenous glucose administration .
7037532	0	glucose	121,128	pancreatic_polypeptide	9,31	glucose	pancreatic polypeptide	MESH:D005947	395564(Tax:9031)	Chemical	Gene	changes|nmod|START_ENTITY responses|nmod|changes Insulin|dep|responses Insulin|appos|END_ENTITY	Insulin , pancreatic_polypeptide , and glucagon release from the chicken pancreas in vitro : responses to changes in medium glucose and free fatty_acid content .
7106344	0	glucose	51,58	pancreatic_polypeptide	25,47	glucose	pancreatic polypeptide	MESH:D005947	280900(Tax:9913)	Chemical	Gene	production|compound|START_ENTITY Lack|nmod|production Lack|nmod|END_ENTITY	Lack of effect of bovine pancreatic_polypeptide on glucose production by isolated rat hepatocytes .
7226566	0	glucose	49,56	pancreatic_polypeptide	9,31	glucose	pancreatic polypeptide	MESH:D005947	5539	Chemical	Gene	diabetes_mellitus|compound|START_ENTITY END_ENTITY|nmod|diabetes_mellitus	Abnormal pancreatic_polypeptide response to oral glucose loading diabetes_mellitus .
752016	0	glucose	47,54	pancreatic_polypeptide	11,33	glucose	pancreatic polypeptide	MESH:D005947	5539	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Control Control|nmod|END_ENTITY	Control of pancreatic_polypeptide secretion by glucose in man .
16132722	0	glucose	5,12	pantothenate_kinase_4	25,46	glucose	pantothenate kinase 4	MESH:D005947	171053(Tax:10116)	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	High glucose upregulates pantothenate_kinase_4 -LRB- PanK4 -RRB- and thus affects M2-type pyruvate kinase -LRB- Pkm2 -RRB- .
18553257	0	glucose	128,135	parathyroid_hormone	98,117	glucose	parathyroid hormone	MESH:D005947	5741	Chemical	Gene	homeostasis|compound|START_ENTITY END_ENTITY|nmod|homeostasis	Effect of exogenous intermittent recombinant human PTH_1-34 administration and chronic endogenous parathyroid_hormone excess on glucose homeostasis and insulin sensitivity .
477623	0	glucose	90,97	parathyroid_hormone	10,29	glucose	parathyroid hormone	MESH:D005947	24694(Tax:10116)	Chemical	Gene	load|compound|START_ENTITY Effect|nmod|load Effect|nmod|END_ENTITY	Effect of parathyroid_hormone on the increase in serum glucose and insulin levels after a glucose load to thyroparathyroidectomized rats .
479365	0	glucose	48,55	parathyroid_hormone	17,36	glucose	parathyroid hormone	MESH:D005947	403986(Tax:9615)	Chemical	Gene	release|compound|START_ENTITY END_ENTITY|nmod|release	Effect of intact parathyroid_hormone on hepatic glucose release in the dog .
6995010	0	glucose	34,41	parathyroid_hormone	11,30	glucose	parathyroid hormone	MESH:D005947	5741	Chemical	Gene	production|compound|START_ENTITY Effects|nmod|production Effects|nmod|END_ENTITY	Effects of parathyroid_hormone on glucose production by the liver .
26975967	0	glucose	5,12	pentraxin-3	49,60	glucose	pentraxin-3	MESH:D005947	689388(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|expression expression|nmod|END_ENTITY	High glucose concentration-induced expression of pentraxin-3 in a rat model of continuous peritoneal_dialysis .
20922652	0	glucose	129,136	peroxisome_proliferator-activated_receptor-y	58,102	glucose	peroxisome proliferator-activated receptor-y	MESH:D005947	5468	Chemical	Gene	uptake|compound|START_ENTITY END_ENTITY|dobj|uptake	Constituents from Cistus salvifolius -LRB- Cistaceae -RRB- activate peroxisome_proliferator-activated_receptor-y but not - and stimulate glucose uptake by adipocytes .
12538575	0	glucose	71,78	phosphatidylinositol_3-kinase	93,122	glucose	phosphatidylinositol 3-kinase	MESH:D005947	373752(Tax:8355)	Chemical	Gene	transport|compound|START_ENTITY transport|nmod|mechanisms mechanisms|amod|END_ENTITY	Granulocyte-macrophage_colony-stimulating_factor signals for increased glucose transport via phosphatidylinositol_3-kinase - and hydrogen_peroxide-dependent mechanisms .
12933351	0	glucose	34,41	phosphatidylinositol_3-kinase	73,102	glucose	phosphatidylinositol 3-kinase	MESH:D005947	18708(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY independent|nsubj|uptake +|ccomp|independent END_ENTITY|dep|+	ATP-sensitive K + channel-mediated glucose uptake is independent of IRS-1 / phosphatidylinositol_3-kinase signaling .
7929393	0	glucose	74,81	phosphatidylinositol_3-kinase	23,52	glucose	phosphatidylinositol 3-kinase	MESH:D005947	373752(Tax:8355)	Chemical	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Evidence for a role of phosphatidylinositol_3-kinase in the regulation of glucose transport in Xenopus oocytes .
9737973	0	glucose	172,179	phosphatidylinositol_3-kinase	103,132	glucose	phosphatidylinositol 3-kinase	MESH:D005947	18708(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY affecting|dobj|transport inhibits|advcl|affecting inhibits|dobj|stimulation stimulation|nmod|receptor receptor|amod|END_ENTITY	Platelet-derived growth factor inhibits insulin stimulation of insulin receptor substrate-1-associated phosphatidylinositol_3-kinase in 3T3-L1 adipocytes without affecting glucose transport .
1314495	0	glucose	47,54	phosphatidylinositol_synthase	14,43	glucose	phosphatidylinositol synthase	MESH:D005947	10423	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of phosphatidylinositol_synthase by glucose in human retinal pigment epithelial cells .
10556529	0	glucose	25,32	phosphoenolpyruvate_carboxykinase	36,69	glucose	phosphoenolpyruvate carboxykinase	MESH:D005947	5106	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	The inhibitory effect of glucose on phosphoenolpyruvate_carboxykinase gene expression in cultured hepatocytes is transcriptional and requires glucose metabolism .
11007965	0	glucose	67,74	phosphoenolpyruvate_carboxykinase	82,115	glucose	phosphoenolpyruvate carboxykinase	MESH:D005947	362282(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY counteracted|dobj|effect counteracted|nmod|expression expression|amod|END_ENTITY	AMP-activated_protein_kinase counteracted the inhibitory effect of glucose on the phosphoenolpyruvate_carboxykinase gene expression in rat hepatocytes .
17446233	0	glucose	32,39	phosphoenolpyruvate_carboxykinase	66,99	glucose	phosphoenolpyruvate carboxykinase	MESH:D005947	378727(Tax:7955)	Chemical	Gene	metabolism|compound|START_ENTITY model|nmod|metabolism zebrafish|nmod|model zebrafish|dep|expression expression|nmod|END_ENTITY	Larval zebrafish as a model for glucose metabolism : expression of phosphoenolpyruvate_carboxykinase as a marker for exposure to anti-diabetic compounds .
23316007	0	glucose	126,133	phosphoenolpyruvate_carboxykinase	58,91	glucose	phosphoenolpyruvate carboxykinase	MESH:D005947	362282(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Dietary n-3 long-chain polyunsaturated fatty_acids modify phosphoenolpyruvate_carboxykinase activity and lipid synthesis from glucose in adipose tissue of rats fed a high-sucrose diet .
9070246	0	glucose	17,24	phosphoenolpyruvate_carboxykinase	34,67	glucose	phosphoenolpyruvate carboxykinase	MESH:D005947	362282(Tax:10116)	Chemical	Gene	modifies|nsubj|START_ENTITY modifies|dobj|expression expression|amod|END_ENTITY	Maternal dietary glucose modifies phosphoenolpyruvate_carboxykinase -LRB- PEPCK -RRB- gene expression in the kidney of newborn rats .
24120946	0	glucose	24,31	phosphofructokinase_1	47,68	glucose	phosphofructokinase 1	MESH:D005947	5213	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|nmod|END_ENTITY	Nucleoredoxin regulates glucose metabolism via phosphofructokinase_1 .
16679292	0	glucose	32,39	phosphoinositide_3-kinase	64,89	glucose	phosphoinositide 3-kinase	MESH:D005947	18708(Tax:10090)	Chemical	Gene	regulation|nmod|START_ENTITY metabolism|nsubj|regulation metabolism|nmod|END_ENTITY	Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide_3-kinase via Akt and PKClambda/zeta .
3530597	0	glucose	15,22	phospholipase_A2	46,62	glucose	phospholipase A2	MESH:D005947	151056	Chemical	Gene	Stimulation|nmod|START_ENTITY Stimulation|nmod|END_ENTITY	Stimulation by glucose and carbamylcholine of phospholipase_A2 in pancreatic islets .
6424179	0	glucose	23,30	phospholipase_A2	3,19	glucose	phospholipase A2	MESH:D005947	151056	Chemical	Gene	sensor|compound|START_ENTITY sensor|nsubj|END_ENTITY	Is phospholipase_A2 a `` glucose sensor '' responsible for the phasic pattern of insulin release ?
14703436	0	glucose	81,88	pigment_epithelium_derived_factor	23,56	glucose	pigment epithelium derived factor	MESH:D005947	57104	Chemical	Gene	concentration|compound|START_ENTITY END_ENTITY|nmod|concentration	-LSB- Downregulation of the pigment_epithelium_derived_factor by hypoxia and elevated glucose concentration in cultured human retinal pigment epithelial cells -RSB- .
15853833	0	glucose	75,82	plasminogen_activator_inhibitor-1	14,47	glucose	plasminogen activator inhibitor-1	MESH:D005947	5054	Chemical	Gene	metabolisms|compound|START_ENTITY effect|nmod|metabolisms effect|nmod|polymorphism polymorphism|amod|END_ENTITY	The effect of plasminogen_activator_inhibitor-1 gene 4G/5G polymorphism on glucose and lipid metabolisms in Turkish obese children .
17275007	0	glucose	5,12	plasminogen_activator_inhibitor-1	21,54	glucose	plasminogen activator inhibitor-1	MESH:D005947	5054	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	High glucose induces plasminogen_activator_inhibitor-1 expression through Rho/Rho-kinase-mediated NF-kappaB activation in bovine aortic endothelial cells .
9525928	0	glucose	82,89	plasminogen_activator_inhibitor-1	36,69	glucose	plasminogen activator inhibitor-1	MESH:D005947	24617(Tax:10116)	Chemical	Gene	mediate|nmod|START_ENTITY mediate|dobj|activation activation|nmod|promoter promoter|amod|END_ENTITY	Sp1 sites mediate activation of the plasminogen_activator_inhibitor-1 promoter by glucose in vascular smooth muscle cells .
8241103	0	glucose	101,108	plasminogen_activator_inhibitor_type-1	29,67	glucose	plasminogen activator inhibitor type-1	MESH:D005947	5054	Chemical	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	Augmentation of synthesis of plasminogen_activator_inhibitor_type-1 in arterial endothelial cells by glucose and its implications for local fibrinolysis .
27033449	0	glucose	5,12	platelet-derived_growth_factor-C	21,53	glucose	platelet-derived growth factor-C	MESH:D005947	54635(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	High glucose induces platelet-derived_growth_factor-C via carbohydrate_response_element-binding_protein in glomerular mesangial cells .
23758845	0	glucose	78,85	plectin	62,69	glucose	plectin	MESH:D005947	18810(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY affects|dobj|uptake affects|nsubj|END_ENTITY	Linking cytoarchitecture to metabolism : sarcolemma-associated plectin affects glucose uptake by destabilizing microtubule networks in mdx myofibers .
16819925	0	glucose	82,89	polyphenol_oxidase	117,135	glucose	polyphenol oxidase	MESH:D005947	5498	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|nmod|END_ENTITY	Use of experimental design methodology to prepare Maillard reaction products from glucose and cysteine inhibitors of polyphenol_oxidase from eggplant -LRB- Solanum melongena -RRB- .
10199783	0	glucose	123,130	proinsulin	82,92	glucose	proinsulin	MESH:D005947	3630	Chemical	Gene	stimulation|nmod|START_ENTITY increases|nmod|stimulation increases|dobj|release release|nmod|END_ENTITY	Prolonged exposure of human beta-cells to high glucose increases their release of proinsulin during acute stimulation with glucose or arginine .
10199783	0	glucose	47,54	proinsulin	82,92	glucose	proinsulin	MESH:D005947	3630	Chemical	Gene	beta-cells|nmod|START_ENTITY exposure|nmod|beta-cells increases|nsubj|exposure increases|dobj|release release|nmod|END_ENTITY	Prolonged exposure of human beta-cells to high glucose increases their release of proinsulin during acute stimulation with glucose or arginine .
1430089	0	glucose	35,42	proinsulin	21,31	glucose	proinsulin	MESH:D005947	3630	Chemical	Gene	turnover|compound|START_ENTITY effects|nmod|turnover effects|nmod|END_ENTITY	The effects of human proinsulin on glucose turnover and intermediary metabolism in insulin-dependent-diabetes_mellitus .
17339029	0	glucose	94,101	proinsulin	116,126	glucose	proinsulin	MESH:D005947	3630	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|translation translation|compound|END_ENTITY	A cis-element in the 5 ' untranslated region of the preproinsulin mRNA -LRB- ppIGE -RRB- is required for glucose regulation of proinsulin translation .
1748243	1	glucose	91,98	proinsulin	62,72	glucose	proinsulin	MESH:D005947	3630	Chemical	Gene	load|compound|START_ENTITY responses|nmod|load responses|compound|END_ENTITY	Insulin , C-peptide , and proinsulin responses to oral glucose load .
17570256	0	glucose	53,60	proinsulin	9,19	glucose	proinsulin	MESH:D005947	3630	Chemical	Gene	stimulation|compound|START_ENTITY secretion|nmod|stimulation secretion|nsubj|END_ENTITY	Impaired proinsulin secretion before and during oral glucose stimulation in HIV-infected patients who display fat redistribution .
1895960	0	glucose	35,42	proinsulin	21,31	glucose	proinsulin	MESH:D005947	3630	Chemical	Gene	turnover|compound|START_ENTITY effects|nmod|turnover effects|nmod|END_ENTITY	The effects of human proinsulin on glucose turnover and intermediary metabolism .
19034419	0	glucose	30,37	proinsulin	53,63	glucose	proinsulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|nmod|processing processing|compound|END_ENTITY	Paired_box_6 -LRB- PAX6 -RRB- regulates glucose metabolism via proinsulin processing mediated by prohormone_convertase_1 / 3 -LRB- PC1/3 -RRB- .
21214701	0	glucose	124,131	proinsulin	71,81	glucose	proinsulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY relationships|nmod|tolerance relationships|nmod|level level|compound|END_ENTITY	Independent relationships of obesity and insulin resistance with serum proinsulin level in prepubertal children with normal glucose tolerance .
21889934	0	glucose	103,110	proinsulin	39,49	glucose	proinsulin	MESH:D005947	3630	Chemical	Gene	test|compound|START_ENTITY values|nmod|test values|nsubj|Evaluation Evaluation|nmod|assay assay|nmod|END_ENTITY	Evaluation of an ELISA assay for total proinsulin and establishment of reference values during an oral glucose tolerance test in a healthy population .
2692943	0	glucose	36,43	proinsulin	16,26	glucose	proinsulin	MESH:D005947	3630	Chemical	Gene	control|compound|START_ENTITY Effect|nmod|control Effect|nmod|END_ENTITY	Effect of human proinsulin on blood glucose control and metabolic instability in type_1_diabetes_mellitus .
3056809	0	glucose	48,55	proinsulin	21,31	glucose	proinsulin	MESH:D005947	3630	Chemical	Gene	infusion|nmod|START_ENTITY infusion|nsubj|Effect Effect|nmod|END_ENTITY	Effect of a two hour proinsulin infusion on the glucose lowering potency of a following insulin injection .
3056814	0	glucose	89,96	proinsulin	63,73	glucose	proinsulin	MESH:D005947	3630	Chemical	Gene	metabolism|compound|START_ENTITY Effects|nmod|metabolism Effects|nmod|END_ENTITY	Effects of single and combined infusions of human biosynthetic proinsulin and insulin on glucose metabolism and on plasma hormone concentrations in euglycaemic clamp experiments .
3318831	0	glucose	53,60	proinsulin	12,22	glucose	proinsulin	MESH:D005947	3630	Chemical	Gene	activated|nmod|START_ENTITY activated|nsubj|Analysis Analysis|nmod|conversion conversion|compound|END_ENTITY	Analysis of proinsulin conversion activated by prior glucose : evidence that glucose stimulates synthesis of the conversion enzyme .
3318831	0	glucose	76,83	proinsulin	12,22	glucose	proinsulin	MESH:D005947	3630	Chemical	Gene	stimulates|nsubj|START_ENTITY evidence|dep|stimulates glucose|dep|evidence activated|nmod|glucose activated|nsubj|Analysis Analysis|nmod|conversion conversion|compound|END_ENTITY	Analysis of proinsulin conversion activated by prior glucose : evidence that glucose stimulates synthesis of the conversion enzyme .
3512341	0	glucose	45,52	proinsulin	24,34	glucose	proinsulin	MESH:D005947	3630	Chemical	Gene	disposal|compound|START_ENTITY action|nmod|disposal action|compound|END_ENTITY	In vivo deactivation of proinsulin action on glucose disposal and hepatic glucose production in normal man .
3549254	0	glucose	18,25	proinsulin	29,39	glucose	proinsulin	MESH:D005947	3630	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|synthesis synthesis|compound|END_ENTITY	Direct effects of glucose on proinsulin synthesis and processing during desensitization .
7758230	0	glucose	64,71	proinsulin	35,45	glucose	proinsulin	MESH:D005947	3630	Chemical	Gene	split|nmod|START_ENTITY split|dobj|END_ENTITY	Increased secretion of 32,33 split proinsulin after intravenous glucose in glucose-tolerant first-degree relatives of patients with non-insulin_dependent_diabetes of European , but not Asian , origin .
8420813	0	glucose	31,38	proinsulin	7,17	glucose	proinsulin	MESH:D005947	3630	Chemical	Gene	responses|nmod|START_ENTITY responses|compound|END_ENTITY	Normal proinsulin responses to glucose in mild type II subjects with subnormal insulin response .
8472625	0	glucose	90,97	proinsulin	34,44	glucose	proinsulin	MESH:D005947	3630	Chemical	Gene	turnover|dep|START_ENTITY split|dobj|turnover split|nsubj|effects effects|nmod|END_ENTITY	The effects of subcutaneous human proinsulin on the production of 64/65 split proinsulin , glucose turnover and intermediary metabolism in non-insulin-dependent diabetic man .
8472625	0	glucose	90,97	proinsulin	78,88	glucose	proinsulin	MESH:D005947	3630	Chemical	Gene	turnover|dep|START_ENTITY turnover|compound|END_ENTITY	The effects of subcutaneous human proinsulin on the production of 64/65 split proinsulin , glucose turnover and intermediary metabolism in non-insulin-dependent diabetic man .
8591697	0	glucose	73,80	proinsulin	31,41	glucose	proinsulin	MESH:D005947	3630	Chemical	Gene	load|compound|START_ENTITY summed|nmod|load summed|dobj|END_ENTITY	Elevated ratio of summed serum proinsulin to insulin response after oral glucose load in type 2 diabetes decreases following sulfonylurea treatment .
8636380	0	glucose	125,132	proinsulin	171,181	glucose	proinsulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY associated|nmod|tolerance proinsulin|acl|associated due|nmod|proinsulin family|amod|due Hyperproinsulinemia|nmod|family Hyperproinsulinemia|dep|contribution contribution|nmod|END_ENTITY	Hyperproinsulinemia in a three-generation Caucasian family due to mutant proinsulin -LRB- Arg65-His -RRB- not associated with imparied glucose tolerance : the contribution of mutant proinsulin to insulin bioactivity .
8636380	0	glucose	125,132	proinsulin	73,83	glucose	proinsulin	MESH:D005947	3630	Chemical	Gene	tolerance|compound|START_ENTITY associated|nmod|tolerance END_ENTITY|acl|associated	Hyperproinsulinemia in a three-generation Caucasian family due to mutant proinsulin -LRB- Arg65-His -RRB- not associated with imparied glucose tolerance : the contribution of mutant proinsulin to insulin bioactivity .
9162608	0	glucose	32,39	proinsulin	9,19	glucose	proinsulin	MESH:D005947	3630	Chemical	Gene	loading|compound|START_ENTITY response|nmod|loading response|compound|END_ENTITY	A higher proinsulin response to glucose loading predicts deteriorating fasting plasma_glucose and worsening to diabetes in subjects with impaired_glucose_tolerance .
9447946	0	glucose	111,118	proinsulin	136,146	glucose	proinsulin	MESH:D005947	16334(Tax:10090)	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nmod|biosynthesis biosynthesis|compound|END_ENTITY	Syntaxin , but not soluble NSF attachment protein -LRB- SNAP -RRB- , biosynthesis by rat pancreatic islets is regulated by glucose in parallel with proinsulin biosynthesis .
9543147	0	glucose	10,17	proinsulin	47,57	glucose	proinsulin	MESH:D005947	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|products products|amod|END_ENTITY	Effect of glucose on production and release of proinsulin conversion products by cultured human islets .
9675108	0	glucose	15,22	proinsulin	40,50	glucose	proinsulin	MESH:D005947	3630	Chemical	Gene	concentration|compound|START_ENTITY concentration|nmod|END_ENTITY	Effect of high glucose concentration on proinsulin biosynthesis and conversion by human islets .
2191185	0	glucose	22,29	prolactin	63,72	glucose	prolactin	MESH:D005947	24683(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY effect|nmod|administration Suppressive|dobj|effect Suppressive|nmod|the the|nmod|END_ENTITY	Suppressive effect of glucose administration on the binding of prolactin by rat liver .
343464	0	glucose	19,26	prolactin	53,62	glucose	prolactin	MESH:D005947	5617	Chemical	Gene	Variation|nmod|START_ENTITY Variation|appos|END_ENTITY	Variation of blood glucose and serum growth_hormone , prolactin and insulin in subjects with insulin-dependent_diabetes , after OGTT and pretreatment with 2-Br-alpha-ergocryptine .
564386	0	glucose	185,192	prolactin	165,174	glucose	prolactin	MESH:D005947	100861193	Chemical	Gene	fatty_acids|compound|START_ENTITY Release|appos|fatty_acids Release|appos|stimuli stimuli|nmod|END_ENTITY	Release of growth_hormone in lactating and non-lactating goats in relation to behaviour , stages of sleep , electroencephalograms , environmental stimuli and levels of prolactin , insulin , glucose and free fatty_acids in the circulation .
7203397	0	glucose	10,17	prolactin	37,46	glucose	prolactin	MESH:D005947	5617	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|response response|compound|END_ENTITY	Effect of glucose of growth_hormone , prolactin and thyroid-stimulating hormone response to diazepam in normal subjects .
8130181	0	glucose	59,66	prolactin	30,39	glucose	prolactin	MESH:D005947	5617	Chemical	Gene	homeostasis|compound|START_ENTITY influence|dobj|homeostasis influence|nsubj|elevation elevation|nmod|END_ENTITY	Acute elevation of endogenous prolactin does not influence glucose homeostasis in healthy men .
9286726	0	glucose	52,59	prolactin	21,30	glucose	prolactin	MESH:D005947	5617	Chemical	Gene	tolerance|compound|START_ENTITY levels|nmod|tolerance levels|compound|END_ENTITY	Suppression of serum prolactin levels after an oral glucose tolerance test in patients with polycystic_ovarian_syndrome .
15699041	0	glucose	76,83	protein-tyrosine_phosphatase_1B	15,46	glucose	protein-tyrosine phosphatase 1B	MESH:D005947	19246(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY homeostasis|amod|END_ENTITY	Liver-specific protein-tyrosine_phosphatase_1B -LRB- PTP1B -RRB- re-expression alters glucose homeostasis of PTP1B - / - mice .
17724080	0	glucose	9,16	protein-tyrosine_phosphatase_1B	70,101	glucose	protein-tyrosine phosphatase 1B	MESH:D005947	19246(Tax:10090)	Chemical	Gene	homeostasis|nsubj|START_ENTITY homeostasis|nmod|mice mice|nmod|deletion deletion|nmod|END_ENTITY	Improved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine_phosphatase_1B .
10497232	0	glucose	29,36	protein_kinase_C-alpha	72,94	glucose	protein kinase C-alpha	MESH:D005947	5578	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|translocation translocation|nmod|END_ENTITY	In L6 skeletal muscle cells , glucose induces cytosolic translocation of protein_kinase_C-alpha and trans-activates the insulin_receptor kinase .
15504985	0	glucose	83,90	protein_tyrosine_phosphatase_1B	15,46	glucose	protein tyrosine phosphatase 1B	MESH:D005947	5770	Chemical	Gene	homeostasis|compound|START_ENTITY measures|nmod|homeostasis polymorphisms|nmod|measures polymorphisms|amod|END_ENTITY	Association of protein_tyrosine_phosphatase_1B gene polymorphisms with measures of glucose homeostasis in Hispanic Americans : the insulin resistance atherosclerosis study -LRB- IRAS -RRB- family study .
23178931	0	glucose	85,92	protein_tyrosine_phosphatase_1B	41,72	glucose	protein tyrosine phosphatase 1B	MESH:D005947	19246(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY uptake|amod|END_ENTITY	Endoplasmic reticulum stress upregulates protein_tyrosine_phosphatase_1B and impairs glucose uptake in cultured myotubes .
23832083	0	glucose	79,86	protein_tyrosine_phosphatase_1B	38,69	glucose	protein tyrosine phosphatase 1B	MESH:D005947	19246(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY improves|dobj|homeostasis improves|nsubj|knockdown knockdown|nmod|END_ENTITY	Inducible liver-specific knockdown of protein_tyrosine_phosphatase_1B improves glucose and lipid homeostasis in adult mice .
12573011	0	glucose	10,17	pyruvate_carboxylase	127,147	glucose	pyruvate carboxylase	MESH:D005947	5091	Chemical	Gene	engineered|nsubj|START_ENTITY engineered|xcomp|express express|dobj|enzyme enzyme|compound|END_ENTITY	Improving glucose and glutamine metabolism of human HEK 293 and Trichoplusia ni insect cells engineered to express a cytosolic pyruvate_carboxylase enzyme .
15507531	0	glucose	82,89	pyruvate_carboxylase	113,133	glucose	pyruvate carboxylase	MESH:D005947	25104(Tax:10116)	Chemical	Gene	flux|compound|START_ENTITY pancreatectomized|nmod|flux pancreatectomized|nmod|pathway pathway|amod|END_ENTITY	Enhanced rat beta-cell proliferation in 60 % pancreatectomized islets by increased glucose metabolic flux through pyruvate_carboxylase pathway .
7771776	0	glucose	13,20	pyruvate_carboxylase	24,44	glucose	pyruvate carboxylase	MESH:D005947	25104(Tax:10116)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|expression expression|amod|END_ENTITY	Influence of glucose on pyruvate_carboxylase expression in pancreatic islets .
6350029	1	glucose	233,240	rabbits	250,257	glucose	insulin	MESH:D005947	100009181(Tax:9986)	Chemical	Gene	level|compound|START_ENTITY level|nmod|END_ENTITY	The amygdala -LRB- AMYG -RRB- stimulation caused a marked decrease in the circulating level of insulin coincident with a considerable rise in the glucose level in rabbits .
14722017	0	glucose	5,12	renin	52,57	glucose	renin	MESH:D005947	24715(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY stimulates|nsubj|concentration stimulates|dobj|activity activity|compound|END_ENTITY	High glucose concentration stimulates intracellular renin activity and angiotensin_II generation in rat mesangial cells .
18216149	0	glucose	63,70	renin	22,27	glucose	renin	MESH:D005947	5972	Chemical	Gene	angiotensin|nmod|START_ENTITY angiotensin|nsubj|Activation Activation|nmod|END_ENTITY	Activation of a local renin angiotensin system in podocytes by glucose .
22049232	0	glucose	49,56	renin	8,13	glucose	renin	MESH:D005947	24715(Tax:10116)	Chemical	Gene	tolerance|compound|START_ENTITY improves|dobj|tolerance improves|nsubj|inhibition inhibition|compound|END_ENTITY	Chronic renin inhibition with aliskiren improves glucose tolerance , insulin sensitivity , and skeletal muscle glucose transport activity in obese Zucker rats .
22049232	9	glucose	1862,1869	renin	1822,1827	glucose	renin	MESH:D005947	24715(Tax:10116)	Chemical	Gene	tolerance|compound|START_ENTITY improvements|nmod|tolerance leads|nmod|improvements leads|nsubj|inhibition inhibition|nmod|activity activity|compound|END_ENTITY	These data provide evidence that chronic selective inhibition of renin activity leads to improvements in glucose tolerance and whole body insulin sensitivity in the insulin-resistant obese Zucker rat .
24337709	0	glucose	5,12	renin	45,50	glucose	renin	MESH:D005947	24715(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|nmod|END_ENTITY	High glucose induces activation of the local renin - angiotensin system in glomerular endothelial cells .
24436324	0	glucose	26,33	renin	56,61	glucose	renin	MESH:D005947	24715(Tax:10116)	Chemical	Gene	metabolite|compound|START_ENTITY Methylglyoxal|appos|metabolite increases|nsubj|Methylglyoxal increases|dobj|aldosterone aldosterone|compound|END_ENTITY	Methylglyoxal , a reactive glucose metabolite , increases renin angiotensin aldosterone and blood pressure in male Sprague-Dawley_rats .
5395843	2	glucose	72,79	renin	83,88	glucose	renin	MESH:D005947	24715(Tax:10116)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|secretion secretion|compound|END_ENTITY	Influence of glucose on renin secretion .
11201732	7	glucose	944,951	resistin	1006,1014	glucose	Resistin	MESH:D005947	57264(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY enhanced|nsubjpass|uptake enhanced|nmod|neutralization neutralization|nmod|END_ENTITY	Insulin-stimulated glucose uptake by adipocytes is enhanced by neutralization of resistin and is reduced by resistin treatment .
12531878	0	glucose	106,113	resistin	16,24	glucose	resistin	MESH:D005947	56729	Chemical	Gene	production|compound|START_ENTITY impair|nmod|production impair|nsubj|END_ENTITY	Adipose-derived resistin and gut-derived resistin-like_molecule-beta selectively impair insulin action on glucose production .
12667367	0	glucose	82,89	resistin	38,46	glucose	resistin	MESH:D005947	56729	Chemical	Gene	level|appos|START_ENTITY level|compound|END_ENTITY	-LSB- The relationship between human serum resistin level and body fat content , plasma glucose as well as blood pressure -RSB- .
14510864	0	glucose	71,78	resistin	6,14	glucose	resistin	MESH:D005947	56729	Chemical	Gene	tolerance|compound|START_ENTITY level|nmod|tolerance level|compound|END_ENTITY	Serum resistin level in essential hypertension patients with different glucose tolerance .
17065346	0	glucose	26,33	resistin	8,16	glucose	resistin	MESH:D005947	57264(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY improves|dobj|homeostasis improves|nsubj|Loss Loss|nmod|END_ENTITY	Loss of resistin improves glucose homeostasis in leptin_deficiency .
17303005	0	glucose	40,47	resistin	22,30	glucose	resistin	MESH:D005947	246250(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY inhibits|dobj|uptake inhibits|nsubj|exposure exposure|nmod|END_ENTITY	Prolonged exposure to resistin inhibits glucose uptake in rat skeletal muscles .
18191042	0	glucose	29,36	resistin	6,14	glucose	resistin	MESH:D005947	56729	Chemical	Gene	loading|compound|START_ENTITY reduced|nmod|loading reduced|nsubjpass|END_ENTITY	Serum resistin is reduced by glucose and meal loading in healthy human subjects .
18196612	0	glucose	39,46	resistin	27,35	glucose	resistin	MESH:D005947	57264(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY Effects|nmod|metabolism Effects|nmod|END_ENTITY	Effects of over-expressing resistin on glucose and lipid metabolism in mice .
19184634	0	glucose	34,41	resistin	11,19	glucose	resistin	MESH:D005947	57264(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY Effects|nmod|metabolism Effects|nmod|expression expression|compound|END_ENTITY	Effects of resistin expression on glucose metabolism and hepatic insulin resistance .
20929509	0	glucose	99,106	retinol-binding_protein_4	6,31	glucose	retinol-binding protein 4	MESH:D005947	5950	Chemical	Gene	tolerance|compound|START_ENTITY associated|nmod|tolerance associated|nsubjpass|END_ENTITY	Serum retinol-binding_protein_4 is associated with insulin secretion in Chinese people with normal glucose tolerance .
2886043	0	glucose	66,73	secretin	20,28	glucose	secretin	MESH:D005947	6343	Chemical	Gene	administration|compound|START_ENTITY relationship|nmod|administration relationship|nmod|levels levels|compound|END_ENTITY	The relationship of secretin and somatostatin levels in plasma to glucose administration and acid secretion during fasting .
408145	0	glucose	62,69	secretin	7,15	glucose	secretin	MESH:D005947	6343	Chemical	Gene	effect|nmod|START_ENTITY concentration|dep|effect concentration|compound|END_ENTITY	Plasma secretin concentration in man : effect of intraduodenal glucose , fat , amino_acids , ethanol , HCl , or ingestion of a meal .
5774112	0	glucose	109,116	secretin	11,19	glucose	secretin	MESH:D005947	6343	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of secretin , pancreozymin , or gastrin on the response of the endocrine pancreas to administration of glucose or arginine in man .
7001613	0	glucose	14,21	secretin	47,55	glucose	secretin	MESH:D005947	6343	Chemical	Gene	effect|nmod|START_ENTITY immunoreactive|nsubj|effect immunoreactive|dobj|END_ENTITY	The effect of glucose on plasma immunoreactive secretin in normal man and after gastrectomy or pancreatectomy .
874055	0	glucose	96,103	secretin	28,36	glucose	secretin	MESH:D005947	6343	Chemical	Gene	specificity|nmod|START_ENTITY effects|dep|specificity effects|nmod|END_ENTITY	The augmentation effects of secretin on the insulin responses to known stimuli : specificity for glucose .
12604697	0	glucose	136,143	semicarbazide-sensitive_amine_oxidase	14,51	glucose	semicarbazide-sensitive amine oxidase	MESH:D005947	11754(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY consequences|nmod|transport Regulation|dep|consequences Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of semicarbazide-sensitive_amine_oxidase expression by tumor_necrosis_factor-alpha in adipocytes : functional consequences on glucose transport .
15000445	0	glucose	15,22	semicarbazide-sensitive_amine_oxidase	36,73	glucose	semicarbazide-sensitive amine oxidase	MESH:D005947	11754(Tax:10090)	Chemical	Gene	Stimulation|nmod|START_ENTITY transport|nsubj|Stimulation transport|nmod|activity activity|amod|END_ENTITY	Stimulation of glucose transport by semicarbazide-sensitive_amine_oxidase activity in adipocytes from diabetic rats .
9525902	0	glucose	49,56	semicarbazide-sensitive_amine_oxidase	8,45	glucose	semicarbazide-sensitive amine oxidase	MESH:D005947	29473(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|nmod|transport	Role of semicarbazide-sensitive_amine_oxidase on glucose transport and GLUT4 recruitment to the cell surface in adipose cells .
1542267	0	glucose	68,75	sex_hormone-binding_globulin	16,44	glucose	sex hormone-binding globulin	MESH:D005947	6462	Chemical	Gene	Relationship|nmod|START_ENTITY Relationship|nmod|END_ENTITY	Relationship of sex_hormone-binding_globulin to lipid , lipoprotein , glucose , and insulin concentrations in postmenopausal women .
16492215	0	glucose	48,55	sex_hormone-binding_globulin	3,31	glucose	sex hormone-binding globulin	MESH:D005947	6462	Chemical	Gene	tolerance|compound|START_ENTITY associated|nmod|tolerance associated|nsubjpass|END_ENTITY	Is sex_hormone-binding_globulin associated with glucose tolerance ?
20839151	0	glucose	116,123	sex_hormone-binding_globulin	62,90	glucose	sex hormone-binding globulin	MESH:D005947	6462	Chemical	Gene	challenge|compound|START_ENTITY responses|nmod|challenge responses|amod|END_ENTITY	Corticosteroid-binding_globulin , cortisol , free cortisol , and sex_hormone-binding_globulin responses following oral glucose challenge in spinal cord-injured and able-bodied men .
21553381	0	glucose	69,76	slc2a10	98,105	glucose	slc2a10	MESH:D005947	560546(Tax:7955)	Chemical	Gene	analysis|nmod|START_ENTITY transporter|nsubj|analysis transporter|dobj|gene gene|appos|END_ENTITY	Characterization and expression pattern analysis of the facilitative glucose transporter 10 gene -LRB- slc2a10 -RRB- in Danio_rerio .
17311585	0	glucose	49,56	snf3	71,75	glucose	snf3	MESH:D005947	851333(Tax:4932)	Chemical	Gene	START_ENTITY|acl|caused caused|nmod|mutation mutation|amod|END_ENTITY	Loss of IRA2 suppresses the growth defect on low glucose caused by the snf3 mutation in Saccharomyces_cerevisiae .
1874412	0	glucose	48,55	snf3	77,81	glucose	snf3	MESH:D005947	851333(Tax:4932)	Chemical	Gene	transport|compound|START_ENTITY restore|dobj|transport restore|nmod|mutant mutant|amod|END_ENTITY	Dominant and recessive suppressors that restore glucose transport in a yeast snf3 mutant .
9046082	0	glucose	147,154	snf3	80,84	glucose	snf3	MESH:D005947	851333(Tax:4932)	Chemical	Gene	recognition|compound|START_ENTITY functions|nmod|recognition defect|dep|functions defect|nmod|mutations mutations|amod|END_ENTITY	The C-terminal domain of Snf3p is sufficient to complement the growth defect of snf3 null mutations in Saccharomyces_cerevisiae : SNF3 functions in glucose recognition .
9559544	0	glucose	107,114	snf3	82,86	glucose	snf3	MESH:D005947	851333(Tax:4932)	Chemical	Gene	required|nmod|START_ENTITY required|nmod|adaptation adaptation|nmod|strains strains|amod|END_ENTITY	The SKS1 gene of Saccharomyces_cerevisiae is required for long-term adaptation of snf3 null strains to low glucose .
1033640	2	glucose	434,441	somatostatin	412,424	glucose	somatostatin	MESH:D005947	6750	Chemical	Gene	revealed|nmod|START_ENTITY revealed|dobj|effect effect|nmod|END_ENTITY	The results obtained in 5 insulin-dependent diabetics and in 4 pancreatectomized patients revealed an inhibitory effect of somatostatin on blood glucose in the juvenile-type diabetics , but failed to show this influence of somatostatin in the pancreatectomized patients .
1113681	0	glucose	64,71	somatostatin	98,110	glucose	somatostatin	MESH:D005947	6750	Chemical	Gene	homeostasis|compound|START_ENTITY glucagon|nmod|homeostasis role|nmod|glucagon Evidence|nmod|role Evidence|dep|studies studies|nmod|END_ENTITY	Evidence for a physiologic role of pancreatic glucagon in human glucose homeostasis : studies with somatostatin .
15827105	0	glucose	35,42	somatostatin	10,22	glucose	somatostatin	MESH:D005947	6750	Chemical	Gene	absorption|compound|START_ENTITY Effect|nmod|absorption Effect|nmod|END_ENTITY	Effect of somatostatin on duodenal glucose absorption in man .
185668	0	glucose	18,25	somatostatin	53,65	glucose	somatostatin	MESH:D005947	24797(Tax:10116)	Chemical	Gene	Inhibition|nmod|START_ENTITY induced|nsubj|Inhibition induced|nmod|END_ENTITY	Inhibition of the glucose induced insulin release by somatostatin in the isolated perfused rat pancreas .
19001517	0	glucose	49,56	somatostatin	10,22	glucose	somatostatin	MESH:D005947	6750	Chemical	Gene	metabolism|compound|START_ENTITY surgery|nmod|metabolism analogs|nmod|surgery analogs|compound|END_ENTITY	Impact of somatostatin analogs versus surgery on glucose metabolism in acromegaly : results of a 5-year observational , open , prospective study .
19208728	0	glucose	35,42	somatostatin	11,23	glucose	somatostatin	MESH:D005947	6750	Chemical	Gene	homeostasis|compound|START_ENTITY analogs|nmod|homeostasis analogs|compound|END_ENTITY	Effects of somatostatin analogs on glucose homeostasis : a metaanalysis of acromegaly studies .
195856	0	glucose	30,37	somatostatin	14,26	glucose	somatostatin	MESH:D005947	24797(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY effect|nmod|uptake effect|nmod|END_ENTITY	The effect of somatostatin on glucose uptake and production by rat tissues in vitro .
1971441	0	glucose	23,30	somatostatin	34,46	glucose	somatostatin	MESH:D005947	24797(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|secretion secretion|compound|END_ENTITY	Abnormal regulation by glucose of somatostatin secretion in the perfused pancreas of NIDDM rats .
21987782	0	glucose	35,42	somatostatin	11,23	glucose	somatostatin	MESH:D005947	24797(Tax:10116)	Chemical	Gene	homeostasis|compound|START_ENTITY analogs|nmod|homeostasis analogs|nsubj|Effects Effects|nmod|END_ENTITY	Effects of somatostatin analogs on glucose homeostasis in rats .
2866155	0	glucose	105,112	somatostatin	67,79	glucose	somatostatin	MESH:D005947	6750	Chemical	Gene	profiles|compound|START_ENTITY analog|nmod|profiles analog|compound|END_ENTITY	Effect of twice daily subcutaneous administration of a long-acting somatostatin analog on 24-hour plasma glucose profiles in patients with insulin-dependent_diabetes_mellitus .
2877536	0	glucose	17,24	somatostatin	54,66	glucose	somatostatin	MESH:D005947	6750	Chemical	Gene	homeostasis|compound|START_ENTITY homeostasis|nmod|analog analog|compound|END_ENTITY	Normalization of glucose homeostasis by a long-acting somatostatin analog SMS 201-995 in a newborn with nesidioblastosis .
2900205	0	glucose	77,84	somatostatin	24,36	glucose	somatostatin	MESH:D005947	6750	Chemical	Gene	homeostasis|compound|START_ENTITY Effect|nmod|homeostasis Effect|nmod|SMS_201-995 SMS_201-995|compound|END_ENTITY	Effect of a long-acting somatostatin derivative SMS_201-995 -LRB- sandostatin -RRB- on glucose homeostasis in type_I_diabetes_mellitus .
484163	0	glucose	40,47	somatostatin	10,22	glucose	somatostatin	MESH:D005947	6750	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of somatostatin -LRB- SRIF -RRB- on plasma glucose and insulin response to glucagon in liver cirrhosis .
6108757	0	glucose	82,89	somatostatin	11,23	glucose	somatostatin	MESH:D005947	443006(Tax:9940)	Chemical	Gene	production|compound|START_ENTITY propionate|nmod|production propionate|nsubj|Effects Effects|nmod|END_ENTITY	Effects of somatostatin and glucagon on the utilization of -LSB- 2 - -LRB- 14 -RRB- C -RSB- propionate in glucose production in vivo in sheep .
6112784	0	glucose	15,22	somatostatin	48,60	glucose	somatostatin	MESH:D005947	403993(Tax:9615)	Chemical	Gene	absorption|compound|START_ENTITY absorption|nmod|END_ENTITY	-LSB- Inhibition of glucose and leucin absorption by somatostatin in the dog -LRB- author 's transl -RRB- -RSB- .
6113182	0	glucose	21,28	somatostatin	38,50	glucose	somatostatin	MESH:D005947	24797(Tax:10116)	Chemical	Gene	exposure|nmod|START_ENTITY enhances|nsubj|exposure enhances|dobj|secretion secretion|compound|END_ENTITY	Previous exposure to glucose enhances somatostatin secretion from the isolated perfused rat pancreas .
6114857	0	glucose	45,52	somatostatin	7,19	glucose	somatostatin	MESH:D005947	24797(Tax:10116)	Chemical	Gene	responds|nmod|START_ENTITY responds|nsubj|END_ENTITY	Portal somatostatin responds to intragastric glucose : effects of streptozotocin diabetes .
6116261	0	glucose	44,51	somatostatin	62,74	glucose	somatostatin	MESH:D005947	403993(Tax:9615)	Chemical	Gene	increments|nmod|START_ENTITY Effect|nmod|increments Effect|nmod|END_ENTITY	Effect of physiological increments of blood glucose on plasma somatostatin and pancreatic polypeptide levels in dogs .
6131942	0	glucose	13,20	somatostatin	24,36	glucose	somatostatin	MESH:D005947	6750	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|synthesis synthesis|compound|END_ENTITY	Influence of glucose on somatostatin synthesis and secretion in isolated cerebral cortical cells .
6134768	0	glucose	70,77	somatostatin	11,23	glucose	somatostatin	MESH:D005947	24797(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A role for somatostatin in the impaired insulin secretory response to glucose by islets from aging rats .
6141177	0	glucose	78,85	somatostatin	22,34	glucose	somatostatin	MESH:D005947	6750	Chemical	Gene	increases|dobj|START_ENTITY increases|nsubj|infusion infusion|nmod|END_ENTITY	Prolonged infusion of somatostatin with glucagon replacement increases plasma glucose and glucose turnover in man .
6144228	0	glucose	81,88	somatostatin	16,28	glucose	somatostatin	MESH:D005947	24797(Tax:10116)	Chemical	Gene	potentiated|nmod|START_ENTITY potentiated|nsubjpass|secretion secretion|compound|END_ENTITY	Glucose-induced somatostatin secretion by the rat pancreas is not potentiated by glucose .
7976418	1	glucose	133,140	somatostatin	100,112	glucose	somatostatin	MESH:D005947	24797(Tax:10116)	Chemical	Gene	glucagon|dep|START_ENTITY glucagon|dep|END_ENTITY	Effects on plasma levels of oxytocin , prolactin , VIP , somatostatin , insulin , glucagon , glucose and of milk secretion in lactating rats .
8095378	0	glucose	24,31	somatostatin	8,20	glucose	somatostatin	MESH:D005947	24797(Tax:10116)	Chemical	Gene	regulation|compound|START_ENTITY Role|nmod|regulation Role|nmod|END_ENTITY	Role of somatostatin in glucose regulation during endotoxicosis in the rat .
8871183	0	glucose	63,70	somatostatin	13,25	glucose	somatostatin	MESH:D005947	6750	Chemical	Gene	load|compound|START_ENTITY Responses|nmod|load Responses|nmod|END_ENTITY	Responses of somatostatin , beta-endorphin and dynorphin_A to a glucose load in two groups of women with polycystic_ovarian_syndrome .
8943764	0	glucose	59,66	somatostatin	19,31	glucose	somatostatin	MESH:D005947	24797(Tax:10116)	Chemical	Gene	responses|nmod|START_ENTITY responses|compound|END_ENTITY	Desensitisation of somatostatin , TRH and GHRH responses to glucose in the diabetic _ -LRB- Goto-Kakizaki -RRB- _ rat_hypothalamus .
946564	2	glucose	151,158	somatostatin	108,120	glucose	somatostatin	MESH:D005947	6750	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Comparison Comparison|nmod|effects effects|nmod|END_ENTITY	Comparison of the effects of somatostatin on insulin release induced by glucose , glucagon and tolbutamide .
2875745	0	glucose	70,77	somatostatin-14	45,60	glucose	somatostatin-14	MESH:D005947	6750	Chemical	Gene	levels|compound|START_ENTITY END_ENTITY|nmod|levels	Effect of a 12-hour subcutaneous infusion of somatostatin-14 on blood glucose , insulin and glucagon levels in healthy subjects and insulin dependent diabetics .
8471633	0	glucose	86,93	staurosporine_and_H-7	28,49	glucose	staurosporine and H-7	MESH:D005947	24783(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|nmod|transport	Primary sites of actions of staurosporine_and_H-7 in the cascade of insulin action to glucose transport in rat adipocytes .
22009727	0	glucose	41,48	substance_P	8,19	glucose	substance P	MESH:D005947	6863	Chemical	Gene	metabolism|compound|START_ENTITY regulation|nmod|metabolism Role|nmod|regulation Role|nmod|END_ENTITY	Role of substance_P in the regulation of glucose metabolism via insulin signaling-associated pathways .
12750016	0	glucose	29,36	sulfonylurea_receptor-1	56,79	glucose	sulfonylurea receptor-1	MESH:D005947	25559(Tax:10116)	Chemical	Gene	RNAs|dep|START_ENTITY RNAs|amod|END_ENTITY	Distribution of glucokinase , glucose transporter GLUT2 , sulfonylurea_receptor-1 , glucagon-like_peptide-1_receptor and neuropeptide_Y messenger RNAs in rat brain by quantitative real time RT-PCR .
7497355	0	glucose	10,17	superoxide_dismutase	25,45	glucose	superoxide dismutase	MESH:D005947	6647	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|production production|amod|END_ENTITY	Effect of glucose on the superoxide_dismutase production in fungal strain Humicola lutea .
21265098	0	glucose	33,40	syndecan-1	86,96	glucose	syndecan-1	MESH:D005947	6382	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|cells cells|amod|END_ENTITY	-LSB- Effect of high concentration of glucose on thickness of glycocalyx and expression of syndecan-1 and glypican-1 in cultured human renal glomerular endothelial cells -RSB- .
24970747	0	glucose	64,71	telomerase_reverse_transcriptase	14,46	glucose	telomerase reverse transcriptase	MESH:D005947	21752(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY regulates|dobj|transport regulates|nsubj|END_ENTITY	Extra-nuclear telomerase_reverse_transcriptase -LRB- TERT -RRB- regulates glucose transport in skeletal muscle cells .
11606315	0	glucose	125,132	thrombin	63,71	glucose	thrombin	MESH:D005947	2147	Chemical	Gene	cultured|nmod|START_ENTITY cells|acl|cultured induced|nmod|cells induced|nmod|END_ENTITY	Pravastatin suppresses the interleukin-8 production induced by thrombin in human aortic endothelial cells cultured with high glucose by inhibiting the p44/42 mitogen activated protein kinase .
21164077	0	glucose	5,12	thrombin	22,30	glucose	thrombin	MESH:D005947	2147	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|responses responses|compound|END_ENTITY	High glucose enhances thrombin responses via protease-activated receptor-4 in human vascular smooth muscle cells .
23032443	0	glucose	50,57	thrombin	143,151	glucose	thrombin	MESH:D005947	2147	Chemical	Gene	electrochemistry|nmod|START_ENTITY oxidase-functionalized|nsubj|electrochemistry oxidase-functionalized|nmod|detection detection|nmod|END_ENTITY	Direct electrochemistry and electrocatalysis of a glucose oxidase-functionalized bioconjugate as a trace label for ultrasensitive detection of thrombin .
24003439	0	glucose	89,96	thrombin	34,42	glucose	thrombin	MESH:D005947	2147	Chemical	Gene	electrochemistry|nmod|START_ENTITY based|nmod|electrochemistry detection|acl|based detection|compound|END_ENTITY	An electrochemical aptasensor for thrombin detection based on direct electrochemistry of glucose oxidase using a functionalized graphene hybrid for amplification .
25928628	0	glucose	12,19	thrombin	48,56	glucose	thrombin	MESH:D005947	2147	Chemical	Gene	associated|nsubjpass|START_ENTITY associated|nmod|generation generation|compound|END_ENTITY	Low fasting glucose is associated with enhanced thrombin generation and unfavorable fibrin clot properties in type 2 diabetic patients with high cardiovascular risk .
2976649	0	glucose	23,30	thrombin	60,68	glucose	thrombin	MESH:D005947	2147	Chemical	Gene	concentration|compound|START_ENTITY changes|nmod|concentration promote|nsubj|changes promote|dobj|generation generation|compound|END_ENTITY	Acute changes in blood glucose concentration do not promote thrombin generation or fibrin breakdown in type 1 diabetes .
8156101	0	glucose	93,100	thrombin	42,50	glucose	thrombin	MESH:D005947	2147	Chemical	Gene	Stimulation|nmod|START_ENTITY Stimulation|nmod|production production|nmod|END_ENTITY	Stimulation of endothelin-1 production by thrombin , but lack of interference by high ambient glucose in vitro .
12882934	0	glucose	75,82	thrombospondin_1	98,114	glucose	thrombospondin 1	MESH:D005947	445442(Tax:10116)	Chemical	Gene	stimulation|compound|START_ENTITY stimulation|nmod|expression expression|amod|END_ENTITY	Expression of constitutively active cGMP-dependent protein kinase prevents glucose stimulation of thrombospondin_1 expression and TGF-beta activity .
16179412	0	glucose	8,15	thyrotropin-releasing_hormone	57,86	glucose	thyrotropin-releasing hormone	MESH:D005947	25569(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|brain brain|amod|END_ENTITY	Altered glucose and insulin responses to brain medullary thyrotropin-releasing_hormone -LRB- TRH -RRB- - induced autonomic activation in type 2 diabetic Goto-Kakizaki rats .
2977989	0	glucose	21,28	thyrotropin-releasing_hormone	39,68	glucose	thyrotropin-releasing hormone	MESH:D005947	25569(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY levels|nmod|END_ENTITY	Modulation of plasma glucose levels by thyrotropin-releasing_hormone administered intracerebroventricularly in the rat .
4624852	0	glucose	58,65	thyrotropin-releasing_hormone	25,54	glucose	thyrotropin-releasing hormone	MESH:D005947	25569(Tax:10116)	Chemical	Gene	oxidation|compound|START_ENTITY END_ENTITY|nmod|oxidation	Stimulation by synthetic thyrotropin-releasing_hormone of glucose oxidation in porcine and rat pituitary slices .
6778968	0	glucose	64,71	thyrotropin-releasing_hormone	10,39	glucose	thyrotropin-releasing hormone	MESH:D005947	25569(Tax:10116)	Chemical	Gene	utilization|compound|START_ENTITY Effect|nmod|utilization Effect|nmod|END_ENTITY	Effect of thyrotropin-releasing_hormone -LRB- TRH -RRB- on local cerebral glucose utilization , by the autoradiographic 2-deoxy -LSB- 14C -RSB- glucose method , in conscious and pentobarbitalized rats .
9827661	0	glucose	100,107	thyrotropin-releasing_hormone	26,55	glucose	thyrotropin-releasing hormone	MESH:D005947	7200	Chemical	Gene	tolerance|compound|START_ENTITY response|nmod|tolerance END_ENTITY|nmod|response	Inhibitory action of oral thyrotropin-releasing_hormone on the glucoregulatory response of the oral glucose tolerance test .
23529237	0	glucose	16,23	toll-like_receptor_4	27,47	glucose	toll-like receptor 4	MESH:D005947	7099	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effect of high glucose on toll-like_receptor_4 expression and LPS-induced proinflammatory cytokine production in hepatic stellate cells in vitro -RSB- .
7474940	0	glucose	20,27	transforming_growth_factor-beta	101,132	glucose	transforming growth factor-beta	MESH:D005947	7040	Chemical	Gene	effects|nmod|START_ENTITY mediated|nsubjpass|effects mediated|nmod|END_ENTITY	The effects of high glucose on human endothelial cell growth and gene expression are not mediated by transforming_growth_factor-beta .
16014625	0	glucose	91,98	transforming_growth_factor-beta_1	15,48	glucose	transforming growth factor-beta 1	MESH:D005947	7040	Chemical	Gene	starvation|compound|START_ENTITY Involvement|nmod|starvation Involvement|nmod|signaling signaling|amod|END_ENTITY	Involvement of transforming_growth_factor-beta_1 signaling in hypoxia-induced tolerance to glucose starvation .
17664181	0	glucose	5,12	transforming_growth_factor-beta_1	98,131	glucose	transforming growth factor-beta 1	MESH:D005947	7040	Chemical	Gene	induces|nsubj|START_ENTITY induces|xcomp|macrophage_inflammatory_protein-3_alpha macrophage_inflammatory_protein-3_alpha|nmod|cells cells|nmod|mechanism mechanism|amod|dependent dependent|amod|END_ENTITY	High glucose induces macrophage_inflammatory_protein-3_alpha in renal proximal tubule cells via a transforming_growth_factor-beta_1 dependent mechanism .
8167156	0	glucose	85,92	transforming_growth_factor-beta_1	14,47	glucose	transforming growth factor-beta 1	MESH:D005947	21803(Tax:10090)	Chemical	Gene	protein|compound|START_ENTITY asparagine-linked_sugar_chains|nmod|protein END_ENTITY|nmod|asparagine-linked_sugar_chains	Alteration by transforming_growth_factor-beta_1 of asparagine-linked_sugar_chains in glucose transporter protein in Swiss_3T3 cells .
8431454	0	glucose	53,60	transforming_growth_factor-beta_1	84,117	glucose	transforming growth factor-beta 1	MESH:D005947	21803(Tax:10090)	Chemical	Gene	synthesis|nmod|START_ENTITY Modulation|nmod|synthesis transporter|nsubj|Modulation transporter|advcl|END_ENTITY	Modulation of the synthesis and glycosylation of the glucose transporter protein by transforming_growth_factor-beta_1 in Swiss_3T3 fibroblasts .
8811326	0	glucose	9,16	transforming_growth_factor-beta_1	34,67	glucose	transforming growth factor-beta 1	MESH:D005947	7040	Chemical	Gene	levels|compound|START_ENTITY stimulate|nsubj|levels stimulate|dobj|END_ENTITY	Elevated glucose levels stimulate transforming_growth_factor-beta_1 -LRB- TGF-beta_1 -RRB- , suppress interleukin IL-2 , IL-6 and IL-10 production and DNA synthesis in peripheral blood mononuclear cells .
2983339	0	glucose	15,22	transforming_growth_factor_beta	33,64	glucose	transforming growth factor beta	MESH:D005947	7040	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|END_ENTITY	Stimulation of glucose uptake by transforming_growth_factor_beta : evidence for the requirement of epidermal_growth_factor-receptor activation .
12205028	0	glucose	30,37	transglutaminase_2	8,26	glucose	transglutaminase 2	MESH:D005947	21817(Tax:10090)	Chemical	Gene	tolerance|compound|START_ENTITY END_ENTITY|nmod|tolerance	Role of transglutaminase_2 in glucose tolerance : knockout mice studies and a putative mutation in a MODY patient .
21304968	0	glucose	116,123	transglutaminase_2	56,74	glucose	transglutaminase 2	MESH:D005947	7052	Chemical	Gene	deprivation|compound|START_ENTITY death|nmod|deprivation potentiates|dobj|death potentiates|nsubj|form form|nmod|END_ENTITY	Cytosolic guanine_nucledotide binding deficient form of transglutaminase_2 -LRB- R580a -RRB- potentiates cell death in oxygen glucose deprivation .
10905474	0	glucose	91,98	tumor_necrosis_factor-alpha	13,40	glucose	tumor necrosis factor-alpha	MESH:D005947	7124	Chemical	Gene	transport|compound|START_ENTITY shows|nmod|transport shows|nsubj|Secretion Secretion|nmod|END_ENTITY	Secretion of tumor_necrosis_factor-alpha shows a strong relationship to insulin-stimulated glucose transport in human adipose tissue .
11061332	0	glucose	5,12	tumor_necrosis_factor-alpha	41,68	glucose	tumor necrosis factor-alpha	MESH:D005947	7124	Chemical	Gene	concentrations|compound|START_ENTITY increase|nsubj|concentrations increase|dobj|capacity capacity|amod|END_ENTITY	High glucose concentrations increase the tumor_necrosis_factor-alpha production capacity by human peripheral blood mononuclear cells .
11341406	0	glucose	89,96	tumor_necrosis_factor-alpha	58,85	glucose	tumor necrosis factor-alpha	MESH:D005947	280943(Tax:9913)	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	Effects of long-term administration of recombinant bovine tumor_necrosis_factor-alpha on glucose metabolism and growth hormone secretion in steers .
12604697	0	glucose	136,143	tumor_necrosis_factor-alpha	66,93	glucose	tumor necrosis factor-alpha	MESH:D005947	21926(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY consequences|nmod|transport Regulation|dep|consequences Regulation|nmod|expression expression|nmod|END_ENTITY	Regulation of semicarbazide-sensitive_amine_oxidase expression by tumor_necrosis_factor-alpha in adipocytes : functional consequences on glucose transport .
12773307	0	glucose	24,31	tumor_necrosis_factor-alpha	58,85	glucose	tumor necrosis factor-alpha	MESH:D005947	7124	Chemical	Gene	uptake|compound|START_ENTITY desensitized|nsubjpass|uptake desensitized|nmod|END_ENTITY	Endothelin-1-stimulated glucose uptake is desensitized by tumor_necrosis_factor-alpha in 3T3-L1 adipocytes .
14693700	0	glucose	80,87	tumor_necrosis_factor-alpha	28,55	glucose	tumor necrosis factor-alpha	MESH:D005947	7124	Chemical	Gene	dependent|advmod|START_ENTITY dependent|nsubj|Stimulation Stimulation|nmod|lipolysis lipolysis|nmod|END_ENTITY	Stimulation of lipolysis by tumor_necrosis_factor-alpha in 3T3-L1 adipocytes is glucose dependent : implications for long-term regulation of lipolysis .
15015154	0	glucose	46,53	tumor_necrosis_factor-alpha	90,117	glucose	tumor necrosis factor-alpha	MESH:D005947	7124	Chemical	Gene	disposal|compound|START_ENTITY enhances|dobj|disposal enhances|nmod|effect effect|nmod|system system|amod|END_ENTITY	Resistance training enhances insulin-mediated glucose disposal with minimal effect on the tumor_necrosis_factor-alpha system in older hypertensives .
18162526	0	glucose	81,88	tumor_necrosis_factor-alpha	29,56	glucose	tumor necrosis factor-alpha	MESH:D005947	7124	Chemical	Gene	amount|nmod|START_ENTITY transporter-4|nsubj|amount increases|xcomp|transporter-4 increases|nsubj|END_ENTITY	The proinflammatory cytokine tumor_necrosis_factor-alpha increases the amount of glucose transporter-4 at the surface of muscle cells independently of changes in interleukin-6 .
18446810	0	glucose	113,120	tumor_necrosis_factor-alpha	46,73	glucose	tumor necrosis factor-alpha	MESH:D005947	7124	Chemical	Gene	death|nmod|START_ENTITY induced|dobj|death END_ENTITY|acl|induced	Elevated fibroblast growth factor-2 increases tumor_necrosis_factor-alpha induced endothelial cell death in high glucose .
2123942	0	glucose	14,21	tumor_necrosis_factor-alpha	35,62	glucose	tumor necrosis factor-alpha	MESH:D005947	21926(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY transport|nmod|END_ENTITY	Regulation of glucose transport by tumor_necrosis_factor-alpha in cultured murine 3T3-L1 fibroblasts .
22234148	0	glucose	25,32	tumor_necrosis_factor-alpha	85,112	glucose	tumor necrosis factor-alpha	MESH:D005947	7124	Chemical	Gene	readings|compound|START_ENTITY readings|nmod|patients patients|acl|treated treated|nmod|inhibitors inhibitors|amod|END_ENTITY	Development of low blood glucose readings in nine non-diabetic patients treated with tumor_necrosis_factor-alpha inhibitors : a case series .
22538117	0	glucose	58,65	tumor_necrosis_factor-alpha	82,109	glucose	tumor necrosis factor-alpha	MESH:D005947	21926(Tax:10090)	Chemical	Gene	mobilization|compound|START_ENTITY reduces|dobj|mobilization reduces|nmod|transgenic_mice transgenic_mice|amod|END_ENTITY	Krill powder increases liver lipid catabolism and reduces glucose mobilization in tumor_necrosis_factor-alpha transgenic_mice fed a high-fat diet .
8159107	0	glucose	42,49	tumor_necrosis_factor-alpha	11,38	glucose	tumor necrosis factor-alpha	MESH:D005947	24835(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY Effects|nmod|production Effects|nmod|END_ENTITY	Effects of tumor_necrosis_factor-alpha on glucose and albumin production in primary cultures of rat hepatocytes .
8781295	0	glucose	70,77	tumor_necrosis_factor-alpha	10,37	glucose	tumor necrosis factor-alpha	MESH:D005947	24835(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY Effect|nmod|transport Effect|nmod|END_ENTITY	Effect of tumor_necrosis_factor-alpha on basal and insulin-stimulated glucose transport in cultured muscle and fat cells .
9202203	0	glucose	93,100	tumor_necrosis_factor-alpha	30,57	glucose	tumor necrosis factor-alpha	MESH:D005947	24835(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY affect|dobj|metabolism fails|xcomp|affect fails|nsubj|exposure exposure|nmod|END_ENTITY	Acute and chronic exposure to tumor_necrosis_factor-alpha fails to affect insulin-stimulated glucose metabolism of isolated rat soleus muscle .
9588442	0	glucose	86,93	tumor_necrosis_factor-alpha	23,50	glucose	tumor necrosis factor-alpha	MESH:D005947	7124	Chemical	Gene	uptake|compound|START_ENTITY affect|dobj|uptake affect|nsubj|exposure exposure|nmod|END_ENTITY	Short-term exposure to tumor_necrosis_factor-alpha does not affect insulin-stimulated glucose uptake in skeletal muscle .
9832415	0	glucose	42,49	tumor_necrosis_factor-alpha	11,38	glucose	tumor necrosis factor-alpha	MESH:D005947	7124	Chemical	Gene	metabolism|compound|START_ENTITY Effects|nmod|metabolism Effects|nmod|END_ENTITY	Effects of tumor_necrosis_factor-alpha on glucose metabolism in cultured human muscle cells from nondiabetic and type 2 diabetic subjects .
20140272	0	glucose	5,12	tyrosyl-tRNA_synthetase	41,64	glucose	tyrosyl-tRNA synthetase	MESH:D005947	313047(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	High glucose inhibits gene expression of tyrosyl-tRNA_synthetase in osteoblast cells .
24447806	0	glucose	149,156	uPA	53,56	glucose	uPA	MESH:D005947	25619(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|effects effects|nmod|END_ENTITY	The effects of urokinase-type_plasminogen_activator -LRB- uPA -RRB- on cell proliferation and phenotypic transformation of rat mesangial cells induced by high glucose .
11843026	0	glucose	110,117	uncoupling_protein_2	62,82	glucose	uncoupling protein 2	MESH:D005947	54315(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|amod|END_ENTITY	Obstructive_jaundice results in increased liver expression of uncoupling_protein_2 and intact skeletal muscle glucose metabolism in the rat .
20814220	0	glucose	5,12	upstream_stimulatory_factor_2	25,54	glucose	upstream stimulatory factor 2	MESH:D005947	7392	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	High glucose upregulates upstream_stimulatory_factor_2 in human renal proximal tubular cells through angiotensin_II-dependent activation of CREB .
10828845	0	glucose	69,76	vascular_endothelial_growth_factor	14,48	glucose	vascular endothelial growth factor	MESH:D005947	83785(Tax:10116)	Chemical	Gene	response|nmod|START_ENTITY Expression|nmod|response Expression|nmod|END_ENTITY	Expression of vascular_endothelial_growth_factor in response to high glucose in rat mesangial cells .
10845612	0	glucose	15,22	vascular_endothelial_growth_factor	36,70	glucose	vascular endothelial growth factor	MESH:D005947	281572(Tax:9913)	Chemical	Gene	transport|compound|START_ENTITY Enhancement|nmod|transport Enhancement|nmod|END_ENTITY	Enhancement of glucose transport by vascular_endothelial_growth_factor in retinal endothelial cells .
14676217	0	glucose	5,12	vascular_endothelial_growth_factor	44,78	glucose	vascular endothelial growth factor	MESH:D005947	7422	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	High glucose enhances interleukin-6-induced vascular_endothelial_growth_factor 165 expression via activation of gp130-mediated p44/42 MAPK-CCAAT/enhancer binding protein signaling in gingival fibroblasts .
15117580	0	glucose	136,143	vascular_endothelial_growth_factor	45,79	glucose	vascular endothelial growth factor	MESH:D005947	83785(Tax:10116)	Chemical	Gene	sensor|compound|START_ENTITY function|nmod|sensor effect|nmod|function effect|nmod|END_ENTITY	The effect of local subcutaneous delivery of vascular_endothelial_growth_factor on the function of a chronically implanted amperometric glucose sensor .
15363662	0	glucose	91,98	vascular_endothelial_growth_factor	36,70	glucose	vascular endothelial growth factor	MESH:D005947	83785(Tax:10116)	Chemical	Gene	impaired|nmod|START_ENTITY impaired|nsubjpass|synthesis synthesis|nmod|END_ENTITY	Nitric_oxide-dependent synthesis of vascular_endothelial_growth_factor is impaired by high glucose .
16597689	0	glucose	5,12	vascular_endothelial_growth_factor	20,54	glucose	vascular endothelial growth factor	MESH:D005947	83785(Tax:10116)	Chemical	Gene	blunts|nsubj|START_ENTITY blunts|dobj|response response|compound|END_ENTITY	High glucose blunts vascular_endothelial_growth_factor response to hypoxia via the oxidative stress-regulated hypoxia-inducible factor/hypoxia-responsible element pathway .
17942749	0	glucose	15,22	vascular_endothelial_growth_factor	76,110	glucose	vascular endothelial growth factor	MESH:D005947	83785(Tax:10116)	Chemical	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|nmod|END_ENTITY	Enhancement of glucose transporter expression of brain endothelial cells by vascular_endothelial_growth_factor derived from glioma exposed to hypoxia .
22949809	0	glucose	16,23	vascular_endothelial_growth_factor	27,61	glucose	vascular endothelial growth factor	MESH:D005947	83785(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|synthesis synthesis|compound|END_ENTITY	Effects of high glucose on vascular_endothelial_growth_factor synthesis and secretion in aortic vascular smooth muscle cells from obese and lean zucker rats .
23274526	0	glucose	5,12	vascular_endothelial_growth_factor	21,55	glucose	vascular endothelial growth factor	MESH:D005947	7422	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|compound|END_ENTITY	High glucose induces vascular_endothelial_growth_factor production in human synovial fibroblasts through reactive oxygen species generation .
9151791	0	glucose	41,48	vascular_endothelial_growth_factor	79,113	glucose	vascular endothelial growth factor	MESH:D005947	83785(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY induced|nmod|levels Vascular_dysfunction|acl|induced mediated|nsubjpass|Vascular_dysfunction mediated|nmod|END_ENTITY	Vascular_dysfunction induced by elevated glucose levels in rats is mediated by vascular_endothelial_growth_factor .
9374757	0	glucose	16,23	vascular_endothelial_growth_factor	27,61	glucose	vascular endothelial growth factor	MESH:D005947	7422	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of high glucose on vascular_endothelial_growth_factor expression in vascular smooth muscle cells .
12963422	0	glucose	106,113	vasoactive_intestinal_polypeptide	11,44	glucose	vasoactive intestinal polypeptide	MESH:D005947	117064(Tax:10116)	Chemical	Gene	absorption|compound|START_ENTITY microinjected|nmod|absorption microinjected|nsubj|Effects Effects|nmod|END_ENTITY	Effects of vasoactive_intestinal_polypeptide microinjected into the nucleus tractus solitarius on jejunal glucose absorption in rats .
3420301	0	glucose	53,60	vasoactive_intestinal_polypeptide	10,43	glucose	vasoactive intestinal polypeptide	MESH:D005947	117064(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY Effect|nmod|metabolism Effect|nmod|END_ENTITY	Effect of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- on glucose and lipid metabolism of isolated rat adipocytes .
10555775	0	glucose	91,98	vimentin	45,53	glucose	vimentin	MESH:D005947	22352(Tax:10090)	Chemical	Gene	levels|nmod|START_ENTITY END_ENTITY|nmod|levels	The impact of genetic removal of GFAP and/or vimentin on glutamine levels and transport of glucose and ascorbate in astrocytes .
16736128	0	glucose	58,65	visfatin	33,41	glucose	visfatin	MESH:D005947	10135	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|release release|nmod|END_ENTITY	The release of the adipocytokine visfatin is regulated by glucose and insulin .
16922702	0	glucose	37,44	visfatin	4,12	glucose	visfatin	MESH:D005947	10135	Chemical	Gene	metabolism|compound|START_ENTITY associated|nmod|metabolism associated|nsubjpass|gene gene|compound|END_ENTITY	The visfatin gene is associated with glucose and lipid metabolism in a Chinese population .
17327330	0	glucose	95,102	visfatin	12,20	glucose	Visfatin	MESH:D005947	10135	Chemical	Gene	tolerance|compound|START_ENTITY subjects|nmod|tolerance associated|nmod|subjects associated|nsubjpass|END_ENTITY	Circulating visfatin is associated with parameters of iron metabolism in subjects with altered glucose tolerance .
19461540	0	glucose	68,75	visfatin	10,18	glucose	visfatin	MESH:D005947	10135	Chemical	Gene	tolerance|compound|START_ENTITY correlates|nmod|tolerance correlates|nsubj|END_ENTITY	Decreased visfatin after exercise training correlates with improved glucose tolerance .
20059442	0	glucose	53,60	visfatin	7,15	glucose	visfatin	MESH:D005947	10135	Chemical	Gene	tolerance|compound|START_ENTITY levels|nmod|tolerance levels|compound|END_ENTITY	Plasma visfatin levels in pregnant women with normal glucose tolerance , gestational diabetes and pre-gestational_diabetes_mellitus .
21266955	0	glucose	162,169	visfatin	6,14	glucose	visfatin	MESH:D005947	10135	Chemical	Gene	metabolism|compound|START_ENTITY secretion|nmod|metabolism modifications|nmod|secretion effect|nmod|modifications END_ENTITY|dep|effect	Serum visfatin and vaspin levels in prepubertal children : effect of obesity and weight_loss after behavior modifications on their secretion and relationship with glucose metabolism .
21677044	0	glucose	40,47	visfatin	23,31	glucose	visfatin	MESH:D005947	10135	Chemical	Gene	uptake|compound|START_ENTITY END_ENTITY|nmod|uptake	In vivo suppression of visfatin by oral glucose uptake : evidence for a novel incretin-like effect by glucagon-like_peptide-1 -LRB- GLP-1 -RRB- .
22446095	0	glucose	38,45	visfatin	11,19	glucose	visfatin	MESH:D005947	10135	Chemical	Gene	tolerance|compound|START_ENTITY levels|nmod|tolerance levels|compound|END_ENTITY	Changes in visfatin levels after oral glucose tolerance test in women with gestational_diabetes_mellitus .
24649111	0	glucose	98,105	visfatin	39,47	glucose	visfatin	MESH:D005947	297508(Tax:10116)	Chemical	Gene	pretreated|nmod|START_ENTITY cardiomyocytes|acl|pretreated END_ENTITY|nmod|cardiomyocytes	MAPK pathway mediates the induction of visfatin in neonatal SD rat cardiomyocytes pretreated with glucose .
25050741	0	glucose	5,12	visfatin	40,48	glucose	visfatin	MESH:D005947	297508(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	High glucose induces Rho/ROCK-dependent visfatin and type I procollagen expression in rat primary cardiac fibroblasts .
27042278	0	glucose	50,57	visfatin	22,30	glucose	visfatin	MESH:D005947	10135	Chemical	Gene	Correlations|nmod|START_ENTITY Correlations|nmod|END_ENTITY	Correlations of serum visfatin and metabolisms of glucose and lipid in women with gestational_diabetes_mellitus .
21155022	0	glucose-6-phosphate	49,68	G6PD	70,74	glucose-6-phosphate	G6PD	MESH:D019298	2539	Chemical	Gene	deficiency|amod|START_ENTITY deficiency|appos|END_ENTITY	G6PD-MutDB : a mutation and phenotype database of glucose-6-phosphate _ -LRB- G6PD -RRB- _ deficiency .
10518030	0	glucose-6-phosphate	17,36	G6PT	50,54	glucose-6-phosphate	G6PT	MESH:D019298	2538	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations in the glucose-6-phosphate transporter -LRB- G6PT -RRB- gene in patients with glycogen storage diseases type 1b and 1c .
1324140	0	glucose_phosphate	136,153	GPI	165,168	glucose phosphate	GPI	CHEBI:21008	2821	Chemical	Gene	isomerase|amod|START_ENTITY isomerase|appos|END_ENTITY	A reciprocal whole-arm translocation , rcp -LRB- 1 ; 6 -RRB- -LRB- 1p6p ; 1q6q -RRB- in a boar , localization of the breakpoints , and reassignment of the genes for glucose_phosphate isomerase -LRB- GPI -RRB- and calcium release channel -LRB- CRC -RRB- .
17041899	0	glucose_phosphate	9,26	GPI	38,41	glucose phosphate	GPI	CHEBI:21008	2821	Chemical	Gene	isomerase|compound|START_ENTITY isomerase|appos|END_ENTITY	Red cell glucose_phosphate isomerase -LRB- GPI -RRB- : a molecular study of three novel mutations associated with hereditary_nonspherocytic_hemolytic_anemia .
1917543	0	glucose_phosphate	32,49	GPI	61,64	glucose phosphate	GPI	CHEBI:21008	280808(Tax:9913)	Chemical	Gene	isomerase|amod|START_ENTITY gene|amod|isomerase gene|appos|END_ENTITY	Chromosomal localization of the glucose_phosphate isomerase -LRB- GPI -RRB- gene in cattle , sheep and goat by in situ hybridization -- chromosomal banding homology versus molecular conservation in Bovidae .
21411499	3	glucose_phosphate	462,479	GPI	491,494	glucose phosphate	OGT	CHEBI:21008	8473	Chemical	Gene	isomerase|amod|START_ENTITY isomerase|appos|END_ENTITY	We retrospectively genotyped 26 single-nucleotide polymorphisms of 5 glucose metabolism genes : glucokinase -LRB- GCK -RRB- , glutamine-fructose-6-phosphate_transaminase_1 -LRB- GFPT1 -RRB- , glucose_phosphate isomerase -LRB- GPI -RRB- , hexokinase_2 -LRB- HK2 -RRB- , and O-linked_N-acetylglucosamine_transferase -LRB- OGT -RRB- in a case-control study of PC conducted at MD Anderson during 2004 to 2010 .
22782259	0	glucose_phosphate	55,72	GPI	162,165	glucose phosphate	GPI	CHEBI:21008	2821	Chemical	Gene	deficiency|amod|START_ENTITY homozygous|nsubj|deficiency homozygous|nmod|mutation mutation|nmod|gene gene|compound|END_ENTITY	Hereditary_non-spherocytic_hemolytic_anemia and severe glucose_phosphate isomerase deficiency in an Indian patient homozygous for the L487F mutation in the human GPI gene .
2387591	0	glucose_phosphate	53,70	GPI	82,85	glucose phosphate	GPI	CHEBI:21008	2821	Chemical	Gene	isomerase|compound|START_ENTITY isomerase|appos|END_ENTITY	Characterization of the 5 ' end of the gene for human glucose_phosphate isomerase -LRB- GPI -RRB- .
26509025	0	glucose_phosphate	55,72	GPI	95,98	glucose phosphate	GPI	CHEBI:21008	2821	Chemical	Gene	START_ENTITY|dep|using using|nsubj|deficiency deficiency|appos|END_ENTITY	Successful treatment of fetal hemolytic_disease due to glucose_phosphate isomerase deficiency -LRB- GPI -RRB- using repeated intrauterine transfusions : a case report .
3325033	0	glucose_phosphate	34,51	GPI	63,66	glucose phosphate	GPI	CHEBI:21008	14751(Tax:10090)	Chemical	Gene	isomerase|amod|START_ENTITY allozymes|amod|isomerase allozymes|appos|END_ENTITY	Immunochemical differentiation of glucose_phosphate isomerase -LRB- GPI -RRB- allozymes of the mouse .
3325033	2	glucose_phosphate	345,362	GPI	374,377	glucose phosphate	GPI	CHEBI:21008	14751(Tax:10090)	Chemical	Gene	isomerase|compound|START_ENTITY isomerase|appos|END_ENTITY	These studies showed a high degree of serological similarity among the three allozymes of mouse glucose_phosphate isomerase -LRB- GPI -RRB- .
422204	0	glucose_phosphate	18,35	GPI	1,4	glucose phosphate	GPI	CHEBI:21008	2821	Chemical	Gene	variant|amod|START_ENTITY Roma|appos|variant Roma|compound|END_ENTITY	` GPI Roma ' , a new glucose_phosphate isomerase deficient variant : in vivo occurrence of postsynthetic modifications of the mutant enzyme .
6217812	0	glucose_phosphate	28,45	GPI	57,60	glucose phosphate	GPI	CHEBI:21008	2821	Chemical	Gene	isomerase|amod|START_ENTITY isomerase|appos|END_ENTITY	Description and genetics of glucose_phosphate isomerase -LRB- GPI -RRB- and phosphoglucomutase -LRB- PGM -RRB- polymorphisms in Asellus aquaticus -LRB- L. -RRB- .
7545951	0	glucose_phosphate	81,98	GPI	110,113	glucose phosphate	GPI	CHEBI:21008	14751(Tax:10090)	Chemical	Gene	isomerase|amod|START_ENTITY gene|amod|isomerase gene|appos|END_ENTITY	Identification of a novel tandemly repeated sequence present in an intron of the glucose_phosphate isomerase -LRB- GPI -RRB- gene in mouse and man .
8062599	0	glucose_phosphate	38,55	GPI	67,70	glucose phosphate	GPI	CHEBI:21008	397602(Tax:9823)	Chemical	Gene	isomerase|amod|START_ENTITY isomerase|appos|END_ENTITY	Precise localization of the genes for glucose_phosphate isomerase -LRB- GPI -RRB- , calcium_release_channel -LRB- CRC -RRB- , hormone-sensitive lipase -LRB- LIPE -RRB- , and growth hormone -LRB- GH -RRB- in pigs , using nonradioactive in situ hybridization .
8530082	0	glucose_phosphate	40,57	GPI	74,77	glucose phosphate	GPI	CHEBI:21008	2821	Chemical	Gene	Structure|nmod|START_ENTITY isomerase|nsubj|Structure isomerase|dobj|gene gene|appos|END_ENTITY	Structure and organization of the human glucose_phosphate isomerase gene -LRB- GPI -RRB- .
9398538	0	glucose_phosphate	36,53	GPI	65,68	glucose phosphate	GPI	CHEBI:21008	2821	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	An exonic polymorphism in the human glucose_phosphate isomerase -LRB- GPI -RRB- gene .
9616041	0	glucose_phosphate	51,68	GPI	80,83	glucose phosphate	GPI	CHEBI:21008	2821	Chemical	Gene	isomerase|compound|START_ENTITY isomerase|appos|END_ENTITY	Expression and enzymatic characterization of human glucose_phosphate isomerase -LRB- GPI -RRB- variants accounting for GPI_deficiency .
15960618	0	glucosinolate	73,86	IQD1	12,16	glucosinolate	IQD1	CHEBI:24279	820128(Tax:3702)	Chemical	Gene	accumulation|amod|START_ENTITY stimulates|dobj|accumulation stimulates|nsubj|END_ENTITY	Arabidopsis IQD1 , a novel calmodulin-binding nuclear protein , stimulates glucosinolate accumulation and plant defense .
18564302	0	glucosinolate	28,41	rapa	67,71	glucosinolate	rapa	CHEBI:24279	55809	Chemical	Gene	accumulation|amod|START_ENTITY accumulation|nmod|END_ENTITY	Quantitative trait loci for glucosinolate accumulation in Brassica rapa leaves .
22355692	0	glucosyl-3-phosphoglycerate	48,75	Rv2419c	27,34	glucosyl-3-phosphoglycerate	Rv2419c	null	885727(Tax:83332)	Chemical	Gene	phosphatase|amod|START_ENTITY END_ENTITY|appos|phosphatase	Mycobacterium_tuberculosis Rv2419c , the missing glucosyl-3-phosphoglycerate phosphatase for the second step in methylglucose lipopolysaccharide biosynthesis .
16967768	0	glucosyl_hesperidin	62,81	apolipoprotein_B	15,31	glucosyl hesperidin	apolipoprotein B	MESH:C487382	338	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Suppression Suppression|nmod|END_ENTITY	Suppression of apolipoprotein_B secretion from HepG2 cells by glucosyl_hesperidin .
24933607	0	glucosylated_hydroxystilbene	36,64	Tyrosinase	0,10	glucosylated hydroxystilbene	Tyrosinase	null	22173(Tax:10090)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Tyrosinase inhibitory activity of a glucosylated_hydroxystilbene in mouse melan-a melanocytes .
15912415	0	glucosylceramide	19,35	beta-glucocerebrosidase	89,112	glucosylceramide	beta-glucocerebrosidase	CHEBI:36500	14466(Tax:10090)	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	An accumulation of glucosylceramide in the stratum corneum due to attenuated activity of beta-glucocerebrosidase is associated with the early phase of UVB-induced alteration in cutaneous barrier function .
9851714	0	glucosylceramide	50,66	carcinoembryonic_antigen	14,38	glucosylceramide	carcinoembryonic antigen	CHEBI:36500	1084	Chemical	Gene	release|nmod|START_ENTITY release|compound|END_ENTITY	Modulation of carcinoembryonic_antigen release by glucosylceramide -- implications for HT29 cell differentiation .
16151977	0	glulisine	8,17	insulin	38,45	glulisine	insulin	null	3630	Chemical	Gene	START_ENTITY|appos|analogue analogue|compound|END_ENTITY	Insulin glulisine , a new rapid-acting insulin analogue , displays a rapid time-action profile in obese non-diabetic subjects .
16308840	0	glulisine	31,40	insulin	23,30	glulisine	insulin	null	3630	Chemical	Gene	START_ENTITY|nsubj|Efficacy Efficacy|nmod|END_ENTITY	Efficacy and safety of insulin glulisine in patients with type 1 diabetes .
18268067	0	glulisine	18,27	insulin	10,17	glulisine	insulin	null	3630	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of insulin glulisine on microvascular blood flow and endothelial function in the postprandial state .
19614946	0	glulisine	19,28	insulin	11,18	glulisine	insulin	null	3630	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of insulin glulisine as mono - or add-on therapy in patients with type_2_diabetes_mellitus .
19614947	0	glulisine	31,40	insulin	23,30	glulisine	insulin	null	3630	Chemical	Gene	START_ENTITY|nsubj|Efficacy Efficacy|nmod|END_ENTITY	Efficacy and safety of insulin glulisine in Japanese patients with type_1_diabetes_mellitus .
21437110	0	glulisine	20,29	insulin	12,19	glulisine	insulin	null	3630	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	The role of insulin glulisine to improve glycemic control in children with diabetes_mellitus .
11705404	0	glutaconyl-coenzyme_A	69,90	glutaryl-CoA_dehydrogenase	100,126	glutaconyl-coenzyme A	glutaryl-CoA dehydrogenase	MESH:C032423	2639	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding , hydration , and decarboxylation of the reaction intermediate glutaconyl-coenzyme_A by human glutaryl-CoA_dehydrogenase .
11292452	6	glutamate	1993,2002	ACPD	2018,2022	glutamate	ACPD	CHEBI:29987	9455	Chemical	Gene	receptors|compound|START_ENTITY receptors|nmod|END_ENTITY	We conclude that , stimulation of metabotropic glutamate receptors with ACPD at concentrations of 2 mM or higher induces a distinct subfield-related and time and concentration dependent pattern of hippocampal_degeneration , and that ACPD at subtoxic concentrations modulates NMDA-induced excitotoxicity through the mGluR5 receptor in a time dependent way .
10465685	0	glutamate	25,34	AIDA	56,60	glutamate	AIDA	CHEBI:29987	682999(Tax:10116)	Chemical	Gene	antagonist|amod|START_ENTITY antagonist|appos|END_ENTITY	The class I metabotropic glutamate receptor antagonist , AIDA , improves short-term and impairs long-term memory in a spatial task for rats .
21575932	5	glutamate	842,851	AMPA	1034,1038	glutamate	NPC1	CHEBI:29987	18145(Tax:10090)	Chemical	Gene	activity|amod|START_ENTITY contribution|nmod|activity evaluate|dobj|contribution recorded|advcl|evaluate recorded|dobj|slices slices|acl|treated treated|nmod|alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic_acid alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic_acid|appos|END_ENTITY	To evaluate the contribution of glutamate receptor activity in the enhanced fPS observed in mutant mice , we recorded slices treated with glutamate receptor agonists alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic_acid -LRB- AMPA -RRB- and Kainate -LRB- KA -RRB- .
21575932	5	glutamate	947,956	AMPA	1034,1038	glutamate	NPC1	CHEBI:29987	18145(Tax:10090)	Chemical	Gene	alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic_acid|amod|START_ENTITY alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic_acid|appos|END_ENTITY	To evaluate the contribution of glutamate receptor activity in the enhanced fPS observed in mutant mice , we recorded slices treated with glutamate receptor agonists alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic_acid -LRB- AMPA -RRB- and Kainate -LRB- KA -RRB- .
26235327	0	glutamate	69,78	AMPA	90,94	glutamate	AMPA	D018698	368416(Tax:7955)	Chemical	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Growth hormone -LRB- GH -RRB- increases cognition and expression of ionotropic glutamate receptors -LRB- AMPA and NMDA -RRB- in transgenic zebrafish -LRB- Danio_rerio -RRB- .
26235327	0	glutamate	69,78	AMPA	90,94	glutamate	AMPA	D018698	368416(Tax:7955)	Chemical	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Growth hormone -LRB- GH -RRB- increases cognition and expression of ionotropic glutamate receptors -LRB- AMPA and NMDA -RRB- in transgenic zebrafish -LRB- Danio_rerio -RRB- .
16429521	0	glutamate	32,41	Acetylcholinesterase	0,20	glutamate	Acetylcholinesterase	CHEBI:29987	83817(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY END_ENTITY|nmod|receptors	Acetylcholinesterase effects on glutamate receptors .
17559977	0	glutamate	60,69	Activator_protein-1	0,19	glutamate	Activator protein-1	CHEBI:29987	24516(Tax:10116)	Chemical	Gene	subtype|compound|START_ENTITY subtype|amod|END_ENTITY	Activator_protein-1 responsive to the group II metabotropic glutamate receptor subtype in association with intracellular calcium in cultured rat cortical neurons .
16182322	0	glutamate	129,138	Akt	14,17	glutamate	Akt	CHEBI:29987	207	Chemical	Gene	transporter|compound|START_ENTITY expression|nmod|transporter increases|nmod|expression increases|nsubj|Evidence Evidence|dep|mediates mediates|nsubj|END_ENTITY	Evidence that Akt mediates platelet-derived growth factor-dependent increases in activity and surface expression of the neuronal glutamate transporter , EAAC1 .
16573655	0	glutamate	25,34	Akt	61,64	glutamate	Akt	CHEBI:29987	207	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Regulation of astrocytic glutamate transporter expression by Akt : evidence for a selective transcriptional effect on the GLT-1 / EAAT2 subtype .
21477044	0	glutamate	65,74	Akt	14,17	glutamate	Akt	CHEBI:29987	207	Chemical	Gene	LY341495|amod|START_ENTITY signaling|nmod|LY341495 Regulation|acl|signaling Regulation|nmod|END_ENTITY	Regulation of Akt and Wnt signaling by the group II metabotropic glutamate receptor antagonist LY341495 and agonist LY379268 .
23592328	0	glutamate	14,23	Akt	0,3	glutamate	Akt	CHEBI:29987	41957(Tax:7227)	Chemical	Gene	trafficking|amod|START_ENTITY regulates|dobj|trafficking regulates|nsubj|END_ENTITY	Akt regulates glutamate receptor trafficking and postsynaptic membrane elaboration at the Drosophila neuromuscular junction .
22539853	0	glutamate	98,107	Arc	127,130	glutamate	Arc	CHEBI:29987	11838(Tax:10090)	Chemical	Gene	translation|amod|START_ENTITY translation|compound|END_ENTITY	Evidence for a fragile_X_mental_retardation protein-mediated translational switch in metabotropic glutamate receptor-triggered Arc translation and long-term depression .
11522946	0	glutamate	13,22	BDNF	0,4	glutamate	BDNF	CHEBI:29987	627	Chemical	Gene	release|amod|START_ENTITY induces|dobj|release induces|nsubj|END_ENTITY	BDNF induces glutamate release in cerebrocortical nerve terminals and in cortical astrocytes .
23326507	0	glutamate	60,69	BDNF	0,4	glutamate	BDNF	CHEBI:29987	24225(Tax:10116)	Chemical	Gene	transporters|compound|START_ENTITY expression|nmod|transporters regulates|dobj|expression regulates|nsubj|END_ENTITY	BDNF regulates the expression and distribution of vesicular glutamate transporters in cultured hippocampal neurons .
11810715	0	glutamate	96,105	BNPI	120,124	glutamate	BNPI	CHEBI:29987	57030	Chemical	Gene	transporters|compound|START_ENTITY transporters|appos|END_ENTITY	Transporters_in_the_neurohypophysial_neuroendocrine_system , with special reference to vesicular glutamate transporters -LRB- BNPI and DNPI -RRB- : a review .
23324492	0	glutamate	28,37	Bestrophin-1	50,62	glutamate	Bestrophin-1	CHEBI:29987	7439	Chemical	Gene	release|compound|START_ENTITY release|nmod|END_ENTITY	Channel-mediated astrocytic glutamate release via Bestrophin-1 targets synaptic NMDARs .
11599006	0	glutamate	51,60	Brain-derived_neurotrophic_factor	0,33	glutamate	Brain-derived neurotrophic factor	CHEBI:29987	627	Chemical	Gene	release|compound|START_ENTITY triggers|dobj|release triggers|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor triggers a rapid glutamate release through increase of intracellular Ca -LRB- 2 + -RRB- and Na -LRB- + -RRB- in cultured_cerebellar_neurons .
11701755	0	glutamate	65,74	Brain-derived_neurotrophic_factor	0,33	glutamate	Brain-derived neurotrophic factor	CHEBI:29987	627	Chemical	Gene	release|compound|START_ENTITY enhances|dobj|release enhances|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor enhances depolarization-evoked glutamate release in cultured cortical neurons .
2449626	0	glutamate	23,32	C-fos	61,66	glutamate	C-fos	CHEBI:29987	314322(Tax:10116)	Chemical	Gene	subtypes|compound|START_ENTITY Activation|nmod|subtypes increases|nsubj|Activation increases|dobj|expression expression|compound|END_ENTITY	Activation of specific glutamate receptor subtypes increases C-fos proto-oncogene expression in primary cultures of neonatal rat cerebellar granule cells .
10093728	0	glutamate	35,44	CA1	106,109	glutamate	CA1	CHEBI:29987	759	Chemical	Gene	receptor|compound|START_ENTITY mediates|nsubj|receptor mediates|nmod|END_ENTITY	Evidence that a novel metabotropic glutamate receptor mediates the induction of long-term potentiation at CA1 synapses in the hippocampus .
10212489	0	glutamate	14,23	CA1	85,88	glutamate	CA1	CHEBI:29987	759	Chemical	Gene	diffusion|compound|START_ENTITY determines|nsubj|diffusion determines|nmod|synapses synapses|nummod|END_ENTITY	Extracellular glutamate diffusion determines the occupancy of glutamate receptors at CA1 synapses in the hippocampus .
10212489	0	glutamate	62,71	CA1	85,88	glutamate	CA1	CHEBI:29987	759	Chemical	Gene	receptors|amod|START_ENTITY occupancy|nmod|receptors determines|dobj|occupancy determines|nmod|synapses synapses|nummod|END_ENTITY	Extracellular glutamate diffusion determines the occupancy of glutamate receptors at CA1 synapses in the hippocampus .
10482734	0	glutamate	37,46	CA1	79,82	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	transmission|amod|START_ENTITY Changes|nmod|transmission Changes|nmod|region region|compound|END_ENTITY	Changes in the calcium dependence of glutamate transmission in the hippocampal CA1 region after brief hypoxia-hypoglycemia .
10568515	0	glutamate	183,192	CA1	135,138	glutamate	CA1	CHEBI:29987	759	Chemical	Gene	responses|amod|START_ENTITY enhancement|nmod|responses relation|nmod|enhancement changes|nmod|relation changes|amod|hippocampal hippocampal|dep|END_ENTITY	Functional changes of N-methyl-D-aspartic_acid and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate channels in gerbil hippocampal CA1 , in relation to postischemic enhancement of glutamate receptor-mediated responses .
10601432	0	glutamate	54,63	CA1	134,137	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY II/III|dobj|receptors II/III|nmod|potentiation potentiation|nmod|END_ENTITY	Evidence for involvement of group II/III metabotropic glutamate receptors in NMDA receptor-independent long-term potentiation in area CA1 of rat hippocampus .
10612629	0	glutamate	29,38	CA1	70,73	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	transporter|amod|START_ENTITY change|nmod|transporter hippocampus|nsubj|change hippocampus|dobj|region region|compound|END_ENTITY	Compensatory change in EAAC1 glutamate transporter in rat hippocampus CA1 region during kindling epileptogenesis .
10613498	0	glutamate	33,42	CA1	131,134	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY contribute|nsubj|receptors contribute|nmod|region region|compound|END_ENTITY	Presynaptic group 1 metabotropic glutamate receptors may contribute to the expression of long-term potentiation in the hippocampal CA1 region .
10634856	0	glutamate	22,31	CA1	72,75	glutamate	CA1	CHEBI:29987	759	Chemical	Gene	microstimulation|amod|START_ENTITY effects|nmod|microstimulation effects|nmod|neurons neurons|nummod|END_ENTITY	Cumulative effects of glutamate microstimulation on Ca -LRB- 2 + -RRB- responses of CA1 hippocampal pyramidal neurons in slice .
11114399	0	glutamate	137,146	CA1	77,80	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY involvement|nmod|receptors high-K|dep|involvement induced|nmod|high-K induced|nmod|slices slices|compound|END_ENTITY	Epileptiform activity and EPSP-spike potentiation induced in rat hippocampal CA1 slices by repeated high-K -LRB- + -RRB- : involvement of ionotropic glutamate receptors and Ca -LRB- 2 + -RRB- / calmodulin-dependent protein kinase II .
11165773	0	glutamate	63,72	CA1	153,156	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY release|acl|delayed delayed|nmod|ischemia ischemia|nmod|END_ENTITY	DOPA cyclohexyl_ester , a competitive DOPA antagonist , protects glutamate release and resultant delayed neuron_death by transient ischemia in hippocampus CA1 of conscious rats .
11487615	0	glutamate	13,22	CA1	65,68	glutamate	CA1	CHEBI:29987	759	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|function function|nummod|END_ENTITY	Metabotropic glutamate receptors 1 and 5 differentially regulate CA1 pyramidal cell function .
11606620	0	glutamate	9,18	CA1	100,103	glutamate	CA1	CHEBI:29987	759	Chemical	Gene	transporters|compound|START_ENTITY limit|nsubj|transporters limit|nmod|spillover spillover|nmod|cells cells|nummod|END_ENTITY	Neuronal glutamate transporters limit activation of NMDA receptors by neurotransmitter spillover on CA1 pyramidal cells .
11873048	0	glutamate	39,48	CA1	105,108	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|region region|compound|END_ENTITY	Effects of dantrolene on extracellular glutamate concentration and neuronal_death in the rat hippocampal CA1 region subjected to transient ischemia .
12117584	0	glutamate	13,22	CA1	94,97	glutamate	CA1	CHEBI:29987	759	Chemical	Gene	receptors|compound|START_ENTITY control|nsubj|receptors control|xcomp|gating gating|nmod|transmission transmission|nmod|END_ENTITY	Metabotropic glutamate receptors control gating of spike transmission in the hippocampus area CA1 .
12351712	0	glutamate	21,30	CA1	145,148	glutamate	CA1	CHEBI:29987	12346(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY secures|nsubj|receptor secures|dobj|induction induction|nmod|potentiation potentiation|nmod|END_ENTITY	Group I metabotropic glutamate receptor signaling via Galpha q/Galpha 11 secures the induction of long-term potentiation in the hippocampal area CA1 .
12388590	0	glutamate	25,34	CA1	129,132	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	agonist|amod|START_ENTITY induces|nsubj|agonist induces|nmod|region region|compound|END_ENTITY	The group I metabotropic glutamate receptor agonist -LRB- S -RRB- -3,5 - dihydroxyphenylglycine induces a novel form of depotentiation in the CA1 region of the hippocampus .
12467877	0	glutamate	30,39	CA1	125,128	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY modulation|nmod|release induced|nsubj|modulation induced|nmod|ischemia ischemia|nmod|neurons neurons|compound|END_ENTITY	The presynaptic modulation of glutamate release and the membrane dysfunction induced by in vitro ischemia in rat hippocampal CA1 neurons .
12480172	0	glutamate	27,36	CA1	163,166	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY Contribution|nmod|receptors induced|nsubj|Contribution induced|nmod|pentylenetetrazol pentylenetetrazol|nmod|region region|compound|END_ENTITY	Contribution of ionotropic glutamate receptors and voltage-dependent calcium channels to the potentiation phenomenon induced by transient pentylenetetrazol in the CA1 region of rat hippocampal slices .
12820982	0	glutamate	26,35	CA1	93,96	glutamate	CA1	CHEBI:29987	759	Chemical	Gene	receptors|compound|START_ENTITY receptors|nmod|release release|nmod|noradrenaline noradrenaline|nmod|END_ENTITY	Implication of ionotropic glutamate receptors in the release of noradrenaline in hippocampal CA1 and CA3 subregions under oxygen and glucose deprivation .
12871773	0	glutamate	49,58	CA1	127,130	glutamate	CA1	CHEBI:29987	100720116	Chemical	Gene	receptors|compound|START_ENTITY activation|nmod|receptors Cooperativity|nmod|activation Cooperativity|nmod|neurons neurons|compound|END_ENTITY	Cooperativity between activation of metabotropic glutamate receptors and NMDA receptors in the induction of LTP in hippocampal CA1 neurons .
12904478	0	glutamate	28,37	CA1	109,112	glutamate	CA1	CHEBI:29987	12346(Tax:10090)	Chemical	Gene	GLT-1|amod|START_ENTITY changes|nmod|GLT-1 changes|dep|study study|nmod|END_ENTITY	Functional changes of glial glutamate transporter GLT-1 during ischemia : an in vivo study in the hippocampal CA1 of normal mice and mutant mice lacking GLT-1 .
1351267	0	glutamate	98,107	CA1	39,42	glutamate	CA1	CHEBI:29987	759	Chemical	Gene	concentration|amod|START_ENTITY increase|nmod|concentration terms|nmod|increase explained|nmod|terms explained|nsubjpass|vulnerability vulnerability|nmod|neurons neurons|compound|END_ENTITY	Selective vulnerability of hippocampal CA1 neurons can not be explained in terms of an increase in glutamate concentration during ischemia in the gerbil : brain microdialysis study .
1355524	0	glutamate	106,115	CA1	88,91	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY mediation|nmod|receptors characterization|dep|mediation characterization|nmod|synapses synapses|nmod|END_ENTITY	Electrophysiological and pharmacological characterization of perforant path synapses in CA1 : mediation by glutamate receptors .
1360314	0	glutamate	14,23	CA1	86,89	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY Inhibition|nmod|release protect|nsubj|Inhibition protect|dobj|cells cells|nummod|END_ENTITY	Inhibition of glutamate release in rat hippocampus by kynurenic_acid does not protect CA1 cells from forebrain_ischemia .
1438239	0	glutamate	10,19	CA1	56,59	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Switch in glutamate receptor subunit gene expression in CA1 subfield of hippocampus following global ischemia in rats .
14750969	0	glutamate	21,30	CA1	97,100	glutamate	CA1	CHEBI:29987	759	Chemical	Gene	receptors|amod|START_ENTITY regulate|nsubj|receptors regulate|dobj|function function|nmod|synapses synapses|compound|END_ENTITY	Group I metabotropic glutamate receptors regulate the frequency-response function of hippocampal CA1 synapses for the induction of LTP and LTD. .
15053957	0	glutamate	21,30	CA1	97,100	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	actions|amod|START_ENTITY actions|nmod|interneurons interneurons|nmod|region region|compound|END_ENTITY	Group I metabotropic glutamate receptor actions in oriens/alveus interneurons of rat hippocampal CA1 region .
15098725	0	glutamate	35,44	CA1	117,120	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	1alpha|amod|START_ENTITY 1alpha|nmod|classes classes|nmod|interneuron interneuron|nmod|region region|compound|END_ENTITY	Immunolocalization of metabotropic glutamate receptor 1alpha -LRB- mGluR1alpha -RRB- in distinct classes of interneuron in the CA1 region of the rat hippocampus .
15152046	0	glutamate	86,95	CA1	156,159	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	depression|amod|START_ENTITY depression|nmod|END_ENTITY	Extracellular_signal-regulated_protein_kinase activation is required for metabotropic glutamate receptor-dependent long-term depression in hippocampal area CA1 .
15157806	0	glutamate	48,57	CA1	20,23	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	reach|nsubj|START_ENTITY synapses|parataxis|reach synapses|nsubj|cap cap|nmod|END_ENTITY	Protective cap over CA1 synapses : extrasynaptic glutamate does not reach the postsynaptic density .
15240770	0	glutamate	13,22	CA1	136,139	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	depression|amod|START_ENTITY gated|nsubjpass|depression gated|nmod|phosphatases phosphatases|nmod|neurons neurons|compound|END_ENTITY	Metabotropic glutamate receptor-mediated depression of the slow afterhyperpolarization is gated by tyrosine phosphatases in hippocampal CA1 pyramidal neurons .
15266351	0	glutamate	47,56	CA1	36,39	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Transient plasticity of hippocampal CA1 neuron glutamate receptors contributes to benzodiazepine withdrawal-anxiety .
15353208	0	glutamate	17,26	CA1	108,111	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY necessary|nsubj|receptor necessary|nmod|potentiation potentiation|nmod|region region|compound|END_ENTITY	The metabotropic glutamate receptor 5 is necessary for late-phase long-term potentiation in the hippocampal CA1 region .
15601737	0	glutamate	68,77	CA1	83,86	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	START_ENTITY|ccomp|receive receive|nsubj|cells cells|nummod|END_ENTITY	Electrophysiological evidence using focal flash photolysis of caged glutamate that CA1 pyramidal cells receive excitatory synaptic input from the subiculum .
15772350	0	glutamate	13,22	CA1	74,77	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	course|amod|START_ENTITY Deriving|dobj|course Deriving|nmod|currents currents|nmod|astrocytes astrocytes|nummod|END_ENTITY	Deriving the glutamate clearance time course from transporter currents in CA1 hippocampal astrocytes : transmitter uptake gets faster during development .
15858055	0	glutamate	92,101	CA1	39,42	glutamate	CA1	CHEBI:29987	759	Chemical	Gene	uptake|amod|START_ENTITY blockade|nmod|uptake enhances|nmod|blockade enhances|dobj|depression depression|compound|END_ENTITY	Behavioral stress enhances hippocampal CA1 long-term depression through the blockade of the glutamate uptake .
15869527	0	glutamate	35,44	CA1	156,159	glutamate	CA1	CHEBI:29987	12346(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY Over-expression|nmod|transporter leads|nsubj|Over-expression leads|nmod|vulnerability vulnerability|nmod|cells cells|nummod|END_ENTITY	Over-expression of the human EAAT2 glutamate transporter within neurons of mouse organotypic hippocampal slice cultures leads to increased vulnerability of CA1 pyramidal cells .
15882781	0	glutamate	19,28	CA1	56,59	glutamate	CA1	CHEBI:29987	12346(Tax:10090)	Chemical	Gene	release|amod|START_ENTITY modulates|dobj|release modulates|nmod|area area|compound|END_ENTITY	Morphine modulates glutamate release in the hippocampal CA1 area in mice .
15882947	0	glutamate	59,68	CA1	103,106	glutamate	CA1	CHEBI:29987	759	Chemical	Gene	receptor|compound|START_ENTITY function|nmod|receptor subtype|nsubj|function subtype|nmod|pyramidal_neurons pyramidal_neurons|compound|END_ENTITY	Global ischemia downregulates the function of metabotropic glutamate receptor subtype 5 in hippocampal CA1 pyramidal_neurons .
16162834	0	glutamate	11,20	CA1	105,108	glutamate	CA1	CHEBI:29987	759	Chemical	Gene	START_ENTITY|nmod|neurons neurons|compound|END_ENTITY	Astrocytic glutamate release-induced transient_depolarization and epileptiform_discharges in hippocampal CA1 pyramidal neurons .
16248989	0	glutamate	45,54	CA1	86,89	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	responses|amod|START_ENTITY responses|nmod|END_ENTITY	Divergent effects of Abeta1-42 on ionotropic glutamate receptor-mediated responses in CA1 neurons in vivo .
16277605	0	glutamate	37,46	CA1	197,200	glutamate	CA1	CHEBI:29987	759	Chemical	Gene	receptor|compound|START_ENTITY activation|nmod|receptor activation|dep|depression depression|nmod|region region|compound|END_ENTITY	Sustained activation of metabotropic glutamate receptor 5 and protein tyrosine phosphatases mediate the expression of -LRB- S -RRB- -3,5 - dihydroxyphenylglycine-induced long-term depression in the hippocampal CA1 region .
16409641	0	glutamate	37,46	CA1	33,36	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	terminals|compound|START_ENTITY terminals|compound|END_ENTITY	Isoflurane depresses hippocampal CA1 glutamate nerve terminals without inhibiting fiber volleys .
16675396	0	glutamate	120,129	CA1	25,28	glutamate	CA1	D018698	759	Chemical	Gene	release|amod|START_ENTITY inhibition|nmod|release loss|nmod|inhibition involves|dobj|loss involves|nsubj|maturation maturation|nmod|synapses synapses|nummod|END_ENTITY	Functional maturation of CA1 synapses involves activity-dependent loss of tonic kainate receptor-mediated inhibition of glutamate release .
1672884	0	glutamate	27,36	CA1	90,93	glutamate	CA1	CHEBI:29987	759	Chemical	Gene	regulation|nmod|START_ENTITY release|nsubj|regulation release|nmod|slices slices|nmod|area area|compound|END_ENTITY	Autoreceptor regulation of glutamate and aspartate release from slices of the hippocampal CA1 area .
16766131	0	glutamate	108,117	CA1	66,69	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	subunits|amod|START_ENTITY expression|nmod|subunits affects|dobj|expression affects|nsubj|potentiation potentiation|nmod|region region|compound|END_ENTITY	N-methyl-D-aspartate receptor-dependent long-term potentiation in CA1 region affects synaptic expression of glutamate receptor subunits and associated proteins in the whole hippocampus .
1680488	0	glutamate	25,34	CA1	58,61	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY Blockade|nmod|receptors protects|nsubj|Blockade protects|dobj|neurons neurons|compound|END_ENTITY	Blockade of metabotropic glutamate receptors protects rat CA1 neurons from hypoxic_injury .
17039485	0	glutamate	107,116	CA1	137,140	glutamate	CA1	CHEBI:29987	759	Chemical	Gene	Difference|nmod|START_ENTITY Difference|acl|receptors receptors|nmod|END_ENTITY	Difference in time course of modulation of synaptic transmission by group II versus group III metabotropic glutamate receptors in region CA1 of the hippocampus .
17767495	0	glutamate	37,46	CA1	117,120	glutamate	CA1	CHEBI:29987	759	Chemical	Gene	Antagonism|nmod|START_ENTITY receptors|nsubj|Antagonism receptors|nmod|region region|compound|END_ENTITY	Antagonism of group III metabotropic glutamate receptors results in impairment of LTD but not LTP in the hippocampal CA1 region , and prevents long-term spatial memory .
18364018	0	glutamate	13,22	CA1	113,116	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	START_ENTITY|ccomp|regulate regulate|nmod|region region|compound|END_ENTITY	Metabotropic glutamate receptor 1 -LRB- mGluR1 -RRB- and 5 -LRB- mGluR5 -RRB- regulate late phases of LTP and LTD in the hippocampal CA1 region in vitro .
18425317	0	glutamate	10,19	CA1	110,113	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	mechanisms|amod|START_ENTITY induced|nsubj|mechanisms induced|nmod|patterns patterns|nmod|area area|compound|END_ENTITY	Different glutamate receptor mechanisms in long-term depression induced by different stimulus patterns in the CA1 area of adult rat hippocampus .
18602428	0	glutamate	35,44	CA1	103,106	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY Activation|nmod|receptors induces|nsubj|Activation induces|nmod|region region|compound|END_ENTITY	Activation of group I metabotropic glutamate receptors induces long-term depression in the hippocampal CA1 region of adult rats in vitro .
19103683	0	glutamate	20,29	CA1	90,93	glutamate	CA1	CHEBI:29987	12346(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY altered|nsubjpass|receptors altered|nmod|field field|compound|END_ENTITY	Synaptic ionotropic glutamate receptors and plasticity are developmentally altered in the CA1 field of Fmr1 knockout mice .
19176803	0	glutamate	19,28	CA1	84,87	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY Role|nmod|receptors hippocampal|nsubj|Role hippocampal|dobj|interneurons interneurons|nummod|END_ENTITY	Role of ionotropic glutamate receptors in long-term potentiation in rat hippocampal CA1 oriens-lacunosum moleculare interneurons .
19232328	0	glutamate	14,23	CA1	41,44	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|nmod|END_ENTITY	Antagonism of glutamate receptors in the CA1 to perirhinal cortex projection prevents long-term potentiation and attenuates levels of brain-derived_neurotrophic_factor .
19665527	0	glutamate	9,18	CA1	85,88	glutamate	CA1	CHEBI:29987	759	Chemical	Gene	transporters|compound|START_ENTITY regulate|nsubj|transporters regulate|nmod|synapses synapses|nmod|neurons neurons|nummod|END_ENTITY	Neuronal glutamate transporters regulate synaptic transmission in single synapses on CA1 hippocampal neurons .
1975452	0	glutamate	24,33	CA1	37,40	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|cells cells|nummod|END_ENTITY	Dendritic_excitation by glutamate in CA1 hippocampal cells .
20107074	0	glutamate	56,65	CA1	121,124	glutamate	CA1	CHEBI:29987	759	Chemical	Gene	START_ENTITY|dobj|depression depression|nmod|cells cells|compound|END_ENTITY	Activation conditions for the induction of metabotropic glutamate receptor-dependent long-term depression in hippocampal CA1 pyramidal cells .
20525770	0	glutamate	32,41	CA1	131,134	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	mGluR5|amod|START_ENTITY mGluR5|nmod|receptor-dependent receptor-dependent|appos|depression depression|nmod|END_ENTITY	Involvement of the metabotropic glutamate receptor mGluR5 in NMDA receptor-dependent , learning-facilitated long-term depression in CA1 synapses .
20569241	0	glutamate	13,22	CA1	134,137	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	uptake|amod|START_ENTITY Reduction|nmod|uptake associated|nsubjpass|Reduction associated|nmod|synapse synapse|compound|END_ENTITY	Reduction in glutamate uptake is associated with extrasynaptic NMDA and metabotropic glutamate receptor activation at the hippocampal CA1 synapse of aged rats .
20667449	0	glutamate	13,22	CA1	114,117	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|phosphorylation phosphorylation|nmod|NR1 NR1|nmod|region region|compound|END_ENTITY	Metabotropic glutamate mGlu5 receptor-mediated serine phosphorylation of NMDA receptor subunit NR1 in hippocampal CA1 region after transient global ischemia in rats .
20853509	0	glutamate	108,117	CA1	155,158	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	subunits|amod|START_ENTITY hippocampal|nsubj|subunits hippocampal|dobj|synapses synapses|nummod|END_ENTITY	Immunogold electron microscopic evidence of differential regulation of GluN1 , GluN2A , and GluN2B , NMDA-type glutamate receptor subunits in rat hippocampal CA1 synapses during benzodiazepine withdrawal .
21103408	0	glutamate	70,79	CA1	151,154	glutamate	CA1	CHEBI:29987	759	Chemical	Gene	upregulation|compound|START_ENTITY mediated|nmod|upregulation mediated|nmod|neurons neurons|nummod|END_ENTITY	A post-burst after depolarization is mediated by group i metabotropic glutamate receptor-dependent upregulation of Ca -LRB- v -RRB- 2.3 R-type calcium channels in CA1 pyramidal neurons .
21218453	0	glutamate	177,186	CA1	116,119	glutamate	CA1	CHEBI:29987	759	Chemical	Gene	receptors|compound|START_ENTITY roles|nmod|receptors plasticity|dep|roles plasticity|acl|induced induced|nmod|synapses synapses|compound|END_ENTITY	Bidirectional synaptic plasticity induced by conditioned stimulations with different number of pulse at hippocampal CA1 synapses : roles of N-methyl-D-aspartate and metabotropic glutamate receptors .
21382441	0	glutamate	60,69	CA1	73,76	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	level|nmod|START_ENTITY increases|dobj|level increases|nmod|END_ENTITY	Morphine sensitization increases the extracellular level of glutamate in CA1 of rat hippocampus via - opioid receptor .
21576272	0	glutamate	13,22	CA1	54,57	glutamate	CA1	CHEBI:29987	759	Chemical	Gene	receptors|compound|START_ENTITY regulate|nsubj|receptors regulate|dobj|excitability excitability|compound|END_ENTITY	Metabotropic glutamate receptors regulate hippocampal CA1 pyramidal neuron excitability via Ca wave-dependent activation of SK and TRPC channels .
21781120	0	glutamate	102,111	CA1	141,144	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	characteristics|nmod|START_ENTITY transporter-1|nsubj|characteristics transporter-1|nmod|subfield subfield|compound|END_ENTITY	Cerebral ischemic pre-conditioning enhances the binding characteristics and glutamate uptake of glial glutamate transporter-1 in hippocampal CA1 subfield of rats .
22314371	0	glutamate	83,92	CA1	32,35	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY changes|nmod|release excitability|nmod|changes excitability|compound|END_ENTITY	Urethane suppresses hippocampal CA1 neuron excitability via changes in presynaptic glutamate release and in potassium channel activity .
22586220	0	glutamate	40,49	CA1	108,111	glutamate	CA1	D018698	12346(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY coupling|nmod|receptor +|nsubj|coupling +|dobj|channel channel|nmod|cells cells|compound|END_ENTITY	Functional coupling of the metabotropic glutamate receptor , InsP3 receptor and L-type Ca2 + channel in mouse CA1 pyramidal cells .
22842516	0	glutamate	190,199	CA1	142,145	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY hippocampus|nmod|receptors END_ENTITY|nmod|hippocampus	Putative depolarisation-induced retrograde signalling accelerates the repeated hypoxic_depression of excitatory synaptic transmission in area CA1 of rat hippocampus via group I metabotropic glutamate receptors .
23511125	0	glutamate	75,84	CA1	95,98	glutamate	CA1	CHEBI:29987	100720116	Chemical	Gene	inputs|amod|START_ENTITY modulation|nmod|inputs reveals|dobj|modulation reveals|nmod|interneurons interneurons|nummod|END_ENTITY	Acetylcholinesterase inhibition reveals endogenous nicotinic modulation of glutamate inputs to CA1 stratum radiatum interneurons in hippocampal slices .
23978512	0	glutamate	21,30	CA1	99,102	glutamate	CA1	CHEBI:29987	759	Chemical	Gene	receptors|amod|START_ENTITY modulate|nsubj|receptors modulate|nmod|neurons neurons|compound|END_ENTITY	Group I metabotropic glutamate receptors modulate late phase long-term potentiation in hippocampal CA1 pyramidal neurons : comparison of apical and basal dendrites .
24094104	0	glutamate	76,85	CA1	37,40	glutamate	CA1	CHEBI:29987	12346(Tax:10090)	Chemical	Gene	depression|amod|START_ENTITY neurons|nmod|depression neurons|nummod|END_ENTITY	Experience-induced Arc/Arg3 .1 primes CA1 pyramidal neurons for metabotropic glutamate receptor-dependent long-term synaptic depression .
24321245	0	glutamate	5,14	CA1	72,75	glutamate	CA1	CHEBI:29987	12346(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|localization localization|nmod|channel channel|nmod|astrocyte astrocyte|compound|END_ENTITY	High glutamate permeability and distal localization of Best1 channel in CA1 hippocampal astrocyte .
25266171	0	glutamate	60,69	CA1	19,22	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	dysregulation|compound|START_ENTITY correlates|nmod|dysregulation correlates|nsubj|glutamate glutamate|nmod|END_ENTITY	Tonic glutamate in CA1 of aging rats correlates with phasic glutamate dysregulation during seizure .
2570785	0	glutamate	51,60	CA1	31,34	glutamate	CA1	CHEBI:29987	759	Chemical	Gene	release|amod|START_ENTITY dependent|nmod|release dependent|nsubj|Ischemic_damage Ischemic_damage|nmod|END_ENTITY	Ischemic_damage in hippocampal CA1 is dependent on glutamate release and intact innervation from CA3 .
26048293	0	glutamate	13,22	CA1	106,109	glutamate	CA1	D018698	759	Chemical	Gene	receptor|compound|START_ENTITY increased|nsubjpass|receptor increased|nmod|region region|compound|END_ENTITY	Metabotropic glutamate receptor 5 , and its trafficking molecules Norbin and Tamalin , are increased in the CA1 hippocampal region of subjects with schizophrenia .
26100337	0	glutamate	12,21	CA1	56,59	glutamate	CA1	D018698	12346(Tax:10090)	Chemical	Gene	release|compound|START_ENTITY release|nmod|collateral collateral|nmod|synapses synapses|nummod|END_ENTITY	Facilitated glutamate release at Schaffer collateral to CA1 synapses has access to an exclusive population of NMDA receptors .
2864279	0	glutamate	75,84	CA1	21,24	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	elicited|nmod|START_ENTITY cells|acl|elicited cells|nummod|END_ENTITY	Repetitive firing of CA1 hippocampal pyramidal cells elicited by dendritic glutamate : slow prepotentials and burst-pause pattern .
2866099	0	glutamate	55,64	CA1	84,87	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	decrement|nmod|START_ENTITY hippocampal|nsubj|decrement hippocampal|dobj|neurons neurons|nummod|END_ENTITY	Calcium and unit response decrement to locally applied glutamate on rat hippocampal CA1 neurons .
2886962	0	glutamate	44,53	CA1	69,72	glutamate	CA1	CHEBI:29987	759	Chemical	Gene	START_ENTITY|nmod|pyramidal pyramidal|compound|END_ENTITY	Hyperpolarizing responses to application of glutamate in hippocampal CA1 pyramidal neurons .
2893830	0	glutamate	35,44	CA1	100,103	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	evidence|nmod|START_ENTITY microapplications|nsubj|evidence microapplications|nmod|circuits circuits|nmod|area area|compound|END_ENTITY	Electrophysiological evidence from glutamate microapplications for local excitatory circuits in the CA1 area of rat hippocampal slices .
2902197	0	glutamate	14,23	CA1	77,80	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY release|nmod|slices slices|nmod|area area|compound|END_ENTITY	Regulation of glutamate and aspartate release from slices of the hippocampal CA1 area : effects of adenosine and baclofen .
469955	0	glutamate	16,25	CA1	69,72	glutamate	CA1	CHEBI:29987	100009083(Tax:9986)	Chemical	Gene	Distribution|nmod|START_ENTITY fields|nsubj|Distribution fields|dobj|END_ENTITY	Distribution of glutamate in layers of the rabbit hippocampal fields CA1 , CA3 , and the dentate area .
7472445	0	glutamate	34,43	CA1	131,134	glutamate	CA1	CHEBI:29987	759	Chemical	Gene	receptors|compound|START_ENTITY modulate|nsubj|receptors modulate|dobj|transmission transmission|nmod|END_ENTITY	Multiple presynaptic metabotropic glutamate receptors modulate excitatory and inhibitory synaptic transmission in hippocampal area CA1 .
7539304	0	glutamate	7,16	CA1	29,32	glutamate	CA1	CHEBI:29987	759	Chemical	Gene	channels|compound|START_ENTITY channels|nmod|END_ENTITY	Single glutamate channels in CA1 pyramidal_neurones after transient ischaemia .
7589200	0	glutamate	77,86	CA1	116,119	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY potentials|nmod|receptors depression|nmod|potentials hippocampal|nsubj|depression hippocampal|dobj|cells cells|nummod|END_ENTITY	Presynaptic depression of inhibitory postsynaptic potentials by metabotropic glutamate receptors in rat hippocampal CA1 pyramidal cells .
7624047	0	glutamate	116,125	CA1	55,58	glutamate	CA1	CHEBI:29987	100720116	Chemical	Gene	receptors|compound|START_ENTITY dependent|nmod|receptors mechanism|amod|dependent induces|nmod|mechanism induces|dobj|potentiation potentiation|nmod|cells cells|nummod|END_ENTITY	Acetylcholinesterase induces long-term potentiation in CA1 pyramidal cells by a mechanism dependent on metabotropic glutamate receptors .
7689143	0	glutamate	13,22	CA1	80,83	glutamate	CA1	CHEBI:29987	759	Chemical	Gene	receptor|amod|START_ENTITY Diversity|nmod|receptor subunit|nsubj|Diversity subunit|nmod|neurons neurons|compound|END_ENTITY	Diversity of glutamate receptor subunit mRNA expression within live hippocampal CA1 neurons .
7821278	0	glutamate	11,20	CA1	94,97	glutamate	CA1	CHEBI:29987	12346(Tax:10090)	Chemical	Gene	high|amod|START_ENTITY potassium|amod|high Effects|nmod|potassium Effects|nmod|area area|nummod|END_ENTITY	Effects of glutamate , N-methyl-D-aspartate , high potassium , and hypoxia on unit discharges in CA1 area of hippocampal slices of DBA and C57 mice .
7861146	0	glutamate	14,23	CA1	78,81	glutamate	CA1	CHEBI:29987	759	Chemical	Gene	Modulation|nmod|START_ENTITY release|nsubj|Modulation release|nmod|slices slices|nmod|END_ENTITY	Modulation of glutamate and aspartate release from slices of hippocampal area CA1 by inhibitors of arachidonic_acid metabolism .
7891083	0	glutamate	11,20	CA1	40,43	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	Release|nmod|START_ENTITY Release|nmod|synaptosomes synaptosomes|nummod|END_ENTITY	Release of glutamate and aspartate from CA1 synaptosomes : selective modulation of aspartate release by ionotropic glutamate receptor ligands .
7891083	0	glutamate	114,123	CA1	40,43	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	ligands|compound|START_ENTITY release|nmod|ligands modulation|nmod|release Release|dep|modulation Release|nmod|synaptosomes synaptosomes|nummod|END_ENTITY	Release of glutamate and aspartate from CA1 synaptosomes : selective modulation of aspartate release by ionotropic glutamate receptor ligands .
7901814	0	glutamate	68,77	CA1	107,110	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY distribution|nmod|receptors hippocampal|nsubj|distribution hippocampal|dobj|neurons neurons|nummod|END_ENTITY	Heterogeneous distribution and developmental change of metabotropic glutamate receptors in rat hippocampal CA1 pyramidal neurons .
7906405	0	glutamate	13,22	CA1	84,87	glutamate	CA1	CHEBI:29987	759	Chemical	Gene	START_ENTITY|nmod|dendrites dendrites|nmod|neurones neurones|compound|END_ENTITY	Metabotropic glutamate receptors and calcium signalling in dendrites of hippocampal CA1 neurones .
7911830	0	glutamate	13,22	CA1	67,70	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	response|compound|START_ENTITY dissociated|nsubj|response dissociated|dobj|neurones neurones|compound|END_ENTITY	Metabotropic glutamate response in acutely dissociated hippocampal CA1 pyramidal neurones of the rat .
7936108	0	glutamate	17,26	CA1	108,111	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	antagonist|amod|START_ENTITY antagonist|dep|alpha-methyl-4-carboxyphenylglycine alpha-methyl-4-carboxyphenylglycine|dep|protects protects|dobj|neurons neurons|compound|END_ENTITY	The metabotropic glutamate receptor antagonist -LRB- + -RRB- - alpha-methyl-4-carboxyphenylglycine protects hippocampal CA1 neurons of the rat from in vitro hypoxia/hypoglycemia .
7964735	0	glutamate	27,36	CA1	51,54	glutamate	CA1	CHEBI:29987	759	Chemical	Gene	efflux|compound|START_ENTITY efflux|nmod|field field|compound|END_ENTITY	Origin of ischemia-induced glutamate efflux in the CA1 field of the gerbil hippocampus : an in vivo brain microdialysis study .
7970244	0	glutamate	53,62	CA1	87,90	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|nmod|potentiation potentiation|nummod|END_ENTITY	Developmental changes in the effects of metabotropic glutamate receptor antagonists on CA1 long-term potentiation in rat hippocampal slices .
8102582	0	glutamate	69,78	CA1	46,49	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	stimulation|amod|START_ENTITY evoked|nmod|stimulation evoked|nmod|cells cells|nummod|END_ENTITY	Hyperpolarizing synaptic potentials evoked in CA1 pyramidal cells by glutamate stimulation of interneurons from the oriens/alveus border of rat hippocampal slices .
8102583	0	glutamate	69,78	CA1	46,49	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	stimulation|amod|START_ENTITY evoked|nmod|stimulation evoked|nmod|cells cells|nummod|END_ENTITY	Hyperpolarizing synaptic potentials evoked in CA1 pyramidal cells by glutamate stimulation of interneurons from the oriens/alveus border of rat hippocampal slices .
8112408	0	glutamate	55,64	CA1	111,114	glutamate	CA1	CHEBI:29987	759	Chemical	Gene	release|nmod|START_ENTITY inhibits|dobj|release inhibits|nmod|slices slices|nmod|END_ENTITY	The neuroprotective agent riluzole inhibits release of glutamate and aspartate from slices of hippocampal area CA1 .
8120608	0	glutamate	104,113	CA1	127,130	glutamate	CA1	CHEBI:29987	759	Chemical	Gene	receptors|compound|START_ENTITY receptors|nmod|neurons neurons|nummod|END_ENTITY	-LRB- RS -RRB- - alpha-methyl-4-carboxyphenylglycine neither prevents induction of LTP nor antagonizes metabotropic glutamate receptors in CA1 hippocampal neurons .
8223907	0	glutamate	13,22	CA1	92,95	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY contribute|nsubj|receptors contribute|nmod|region region|compound|END_ENTITY	Metabotropic glutamate receptors contribute to the induction of long-term depression in the CA1 region of the hippocampus .
8358622	0	glutamate	9,18	CA1	47,50	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	destroy|nsubj|START_ENTITY destroy|dobj|structure structure|compound|END_ENTITY	Neonatal glutamate can destroy the hippocampal CA1 structure and impair discrimination learning in rats .
8381524	0	glutamate	53,62	CA1	94,97	glutamate	CA1	CHEBI:29987	759	Chemical	Gene	receptors|amod|START_ENTITY activation|nmod|receptors induced|nmod|activation induced|nmod|END_ENTITY	Characterisation of LTP induced by the activation of glutamate metabotropic receptors in area CA1 of the hippocampus .
8515845	0	glutamate	30,39	CA1	158,161	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	Co-activation|nmod|START_ENTITY involved|nsubjpass|Co-activation involved|nmod|mechanisms mechanisms|nmod|maintenance maintenance|nmod|neurons neurons|compound|END_ENTITY	Co-activation of metabotropic glutamate and N-methyl-D-aspartate receptors is involved in mechanisms of long-term potentiation maintenance in rat hippocampal CA1 neurons .
8528571	0	glutamate	42,51	CA1	81,84	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY Pharmacology|nmod|receptors hippocampal|nsubj|Pharmacology hippocampal|dobj|pyramidal_neurones pyramidal_neurones|nummod|END_ENTITY	Pharmacology of postsynaptic metabotropic glutamate receptors in rat hippocampal CA1 pyramidal_neurones .
8549641	0	glutamate	23,32	CA1	58,61	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY actions|nmod|receptor agonists|nsubj|actions agonists|nmod|region region|compound|END_ENTITY	Presynaptic actions of glutamate receptor agonists in the CA1 region of rat hippocampus in vitro .
8570032	0	glutamate	13,22	CA1	92,95	glutamate	CA1	CHEBI:29987	759	Chemical	Gene	receptors|compound|START_ENTITY involved|nsubjpass|receptors involved|nmod|potentiation potentiation|nmod|END_ENTITY	Metabotropic glutamate receptors are involved in TEA-induced long-term potentiation in area CA1 of the hippocampus .
8773144	0	glutamate	116,125	CA1	63,66	glutamate	CA1	CHEBI:29987	759	Chemical	Gene	role|dep|START_ENTITY role|nmod|terminals terminals|nmod|END_ENTITY	The role of remaining presynaptic terminals in the hippocampal CA1 after selective neuronal_death : ischemia-induced glutamate efflux .
8815209	0	glutamate	55,64	CA1	102,105	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	channels|amod|START_ENTITY channels|nmod|neurones neurones|compound|END_ENTITY	Fractional Ca2 + currents through somatic and dendritic glutamate receptor channels of rat hippocampal CA1 pyramidal neurones .
8830317	0	glutamate	13,22	CA1	146,149	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	antagonist|amod|START_ENTITY Metabotropic|dep|antagonist blocks|nsubj|Metabotropic blocks|nmod|END_ENTITY	Metabotropic glutamate receptor antagonist , -LRB- R , S -RRB- - alpha-methyl-4-carboxyphenyglycine , blocks two distinct forms of long-term potentiation in area CA1 of rat hippocampus .
8845958	0	glutamate	13,22	CA1	71,74	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY synapses|nsubj|receptors synapses|nmod|area area|compound|END_ENTITY	Metabotropic glutamate receptors inhibiting excitatory synapses in the CA1 area of rat hippocampus .
8873121	0	glutamate	11,20	CA1	111,114	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY Effects|nmod|receptor agonists|nsubj|Effects agonists|nmod|Ca Ca|dep|signals signals|nmod|END_ENTITY	Effects of glutamate receptor agonists on presumed presynaptic Ca -LRB- 2 + -RRB- - signals in juvenile rat hippocampal area CA1 .
8997504	0	glutamate	32,41	CA1	17,20	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	neurons|nmod|START_ENTITY neurons|nummod|END_ENTITY	Vulnerability of CA1 neurons to glutamate is developmentally regulated .
9017237	0	glutamate	58,67	CA1	172,175	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	participate|nsubj|START_ENTITY participate|nmod|mechanism mechanism|nmod|death death|nmod|neurons neurons|nummod|END_ENTITY	In vitro hypoxia of cortical and hippocampal CA1 neurons : glutamate , nitric_oxide , and platelet activating factor participate in the mechanism of selective neural death in CA1 neurons .
9017237	0	glutamate	58,67	CA1	45,48	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	participate|nsubj|START_ENTITY participate|nmod|hypoxia hypoxia|nmod|neurons neurons|compound|END_ENTITY	In vitro hypoxia of cortical and hippocampal CA1 neurons : glutamate , nitric_oxide , and platelet activating factor participate in the mechanism of selective neural death in CA1 neurons .
9098682	0	glutamate	36,45	CA1	126,129	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY Activation|nmod|receptors blocks|nsubj|Activation blocks|nmod|END_ENTITY	Activation of group-II metabotropic glutamate receptors blocks induction of long-term potentiation and depotentiation in area CA1 of the rat in vivo .
9119902	0	glutamate	25,34	CA1	87,90	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY Expression|nmod|receptor subunits|nsubj|Expression subunits|nmod|cells cells|nmod|area area|compound|END_ENTITY	Expression of ionotropic glutamate receptor subunits in glial cells of the hippocampal CA1 area following transient forebrain_ischemia .
9204921	0	glutamate	148,157	CA1	171,174	glutamate	CA1	CHEBI:29987	759	Chemical	Gene	receptors|compound|START_ENTITY stimulation|nmod|receptors generated|nmod|stimulation generated|nmod|neurons neurons|nummod|END_ENTITY	A long-lasting calcium-activated nonselective cationic current is generated by synaptic stimulation or exogenous activation of group I metabotropic glutamate receptors in CA1 pyramidal neurons .
9347342	0	glutamate	34,43	CA1	82,85	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY activation|nmod|receptors impaired|nsubj|activation impaired|nmod|area area|compound|END_ENTITY	Is activation of the metabotropic glutamate receptors impaired in the hippocampal CA1 area of the aged rat ?
9374203	0	glutamate	30,39	CA1	68,71	glutamate	CA1	CHEBI:29987	759	Chemical	Gene	release|amod|START_ENTITY inhibition|nmod|release inhibition|nmod|END_ENTITY	Proline-induced inhibition of glutamate release in hippocampal area CA1 .
9517423	0	glutamate	21,30	CA1	90,93	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY contribute|nsubj|receptors contribute|xcomp|slow-onset slow-onset|nmod|region region|compound|END_ENTITY	Group 1 metabotropic glutamate receptors contribute to slow-onset potentiation in the rat CA1 region in vivo .
9554954	0	glutamate	74,83	CA1	26,29	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY evoked|dobj|release relationship|acl|evoked neurons|dep|relationship neurons|compound|END_ENTITY	Hypoxia-tolerant neonatal CA1 neurons : relationship of survival to evoked glutamate release and glutamate receptor-mediated calcium changes in hippocampal slices .
9566055	0	glutamate	65,74	CA1	88,91	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY I|nmod|receptors Influence|nmod|I Influence|nmod|region region|nummod|END_ENTITY	Influence of imipramine treatment on the group I of metabotropic glutamate receptors in CA1 region of hippocampus .
9634553	0	glutamate	26,35	CA1	140,143	glutamate	CA1	CHEBI:29987	759	Chemical	Gene	receptor|compound|START_ENTITY Evidence|nmod|receptor activation|nsubj|Evidence activation|nmod|induction induction|nmod|suppression suppression|nmod|inhibition inhibition|nmod|END_ENTITY	Evidence for metabotropic glutamate receptor activation in the induction of depolarization-induced suppression of inhibition in hippocampal CA1 .
9669500	0	glutamate	47,56	CA1	107,110	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|nmod|slices slices|nmod|region region|compound|END_ENTITY	Antidepressant treatment influences group I of glutamate metabotropic receptors in slices from hippocampal CA1 region .
9753587	0	glutamate	41,50	CA1	111,114	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|forms forms|nmod|coexist coexist|nmod|cells cells|nummod|END_ENTITY	NMDA receptor-dependent and metabotropic glutamate receptor-dependent forms of long-term depression coexist in CA1 hippocampal pyramidal cells .
9758165	0	glutamate	97,106	CA1	44,47	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY independent|nmod|receptors activation|amod|independent hippocampus|dobj|activation hippocampus|nsubj|form form|nmod|depression depression|nmod|area area|compound|END_ENTITY	A novel form of long-term depression in the CA1 area of the adult rat hippocampus independent of glutamate receptors activation .
9774245	0	glutamate	34,43	CA1	69,72	glutamate	CA1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY role|nmod|receptors role|nmod|potentiation potentiation|compound|END_ENTITY	The role of group II metabotropic glutamate receptors in hippocampal CA1 long-term potentiation in vitro .
11247988	0	glutamate	62,71	CA3	106,109	glutamate	CA3	CHEBI:29987	54232(Tax:10116)	Chemical	Gene	responses|amod|START_ENTITY responses|nmod|END_ENTITY	Zinc-induced augmentation of excitatory synaptic currents and glutamate receptor responses in hippocampal CA3 neurons .
11744247	0	glutamate	97,106	CA3	56,59	glutamate	CA3	CHEBI:29987	54232(Tax:10116)	Chemical	Gene	pathway|amod|START_ENTITY neurons|nmod|pathway neurons|nummod|END_ENTITY	Hippocampal mossy fiber activity evokes Ca2 + release in CA3 pyramidal neurons via a metabotropic glutamate receptor pathway .
12372016	0	glutamate	53,62	CA3	100,103	glutamate	CA3	CHEBI:29987	54232(Tax:10116)	Chemical	Gene	currents|amod|START_ENTITY currents|nmod|synapse synapse|compound|END_ENTITY	The antidepressant tianeptine persistently modulates glutamate receptor currents of the hippocampal CA3 commissural associational synapse in chronically stressed rats .
12902026	0	glutamate	8,17	CA3	153,156	glutamate	CA3	CHEBI:29987	12350(Tax:10090)	Chemical	Gene	receptors|amod|START_ENTITY Role|nmod|receptors Role|nmod|region region|compound|END_ENTITY	Role of glutamate receptors and an on-going protein synthesis in the regulation of phosphorylation of Ca2 + / calmodulin-dependent_protein_kinase_II in the CA3 hippocampal region in mice administered with kainic_acid intracerebroventricularly .
1359036	0	glutamate	78,87	CA3	38,41	glutamate	CA3	CHEBI:29987	54232(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY neurons|nmod|receptor neurons|nsubj|Inhibition Inhibition|nmod|channels channels|nmod|pyramidal pyramidal|compound|END_ENTITY	Inhibition of calcium channels in rat CA3 pyramidal neurons by a metabotropic glutamate receptor .
14578486	0	glutamate	100,109	CA3	63,66	glutamate	CA3	CHEBI:29987	100306971(Tax:10141)	Chemical	Gene	receptors|compound|START_ENTITY neurones|nmod|receptors neurones|nsubj|Modulation Modulation|nmod|END_ENTITY	Modulation of afterpotentials and firing pattern in guinea_pig CA3 neurones by group I metabotropic glutamate receptors .
16378694	0	glutamate	51,60	CA3	128,131	glutamate	CA3	CHEBI:29987	54232(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY facilitate|dobj|release facilitate|nmod|terminals terminals|nmod|neurons neurons|compound|END_ENTITY	Presynaptic GABAA receptors facilitate spontaneous glutamate release from presynaptic terminals on mechanically dissociated rat CA3 pyramidal neurons .
17344368	0	glutamate	21,30	CA3	60,63	glutamate	CA3	CHEBI:29987	761	Chemical	Gene	release|amod|START_ENTITY Desynchronization|nmod|release prolongs|nsubj|Desynchronization prolongs|dobj|activity activity|compound|END_ENTITY	Desynchronization of glutamate release prolongs synchronous CA3 network activity .
17883401	0	glutamate	51,60	CA3	72,75	glutamate	CA3	D018698	12350(Tax:10090)	Chemical	Gene	release|amod|START_ENTITY regulates|dobj|release regulates|nmod|synapses synapses|nummod|END_ENTITY	Expression of functional Kir6 .1 channels regulates glutamate release at CA3 synapses in generation of epileptic form of seizures .
19535175	0	glutamate	23,32	CA3	48,51	glutamate	CA3	CHEBI:29987	54232(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	Age-related changes in glutamate release in the CA3 and dentate gyrus of the rat hippocampus .
19950194	0	glutamate	91,100	CA3	77,80	glutamate	CA3	CHEBI:29987	54232(Tax:10116)	Chemical	Gene	causes|nmod|START_ENTITY causes|dobj|dendritic_atrophy_of_pyramidal_neurons dendritic_atrophy_of_pyramidal_neurons|nmod|region region|compound|END_ENTITY	Prenatal_stress causes dendritic_atrophy_of_pyramidal_neurons in hippocampal CA3 region by glutamate in offspring rats .
19961906	0	glutamate	44,53	CA3	116,119	glutamate	CA3	CHEBI:29987	54232(Tax:10116)	Chemical	Gene	inhibition|amod|START_ENTITY contribute|nmod|inhibition contribute|nmod|pyramidal_neurons pyramidal_neurons|compound|END_ENTITY	Endocannabinoids contribute to metabotropic glutamate receptor-mediated inhibition of GABA release onto hippocampal CA3 pyramidal_neurons in an isolated neuron/bouton preparation .
21628565	0	glutamate	87,96	CA3	15,18	glutamate	CA3	CHEBI:29987	12350(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY activation|nmod|receptors hippocampal|nmod|activation hippocampal|nsubj|Enhancement Enhancement|nmod|END_ENTITY	Enhancement of CA3 hippocampal network activity by activation of group II metabotropic glutamate receptors .
2570785	0	glutamate	51,60	CA3	97,100	glutamate	CA3	CHEBI:29987	761	Chemical	Gene	release|amod|START_ENTITY dependent|nmod|release dependent|nmod|END_ENTITY	Ischemic_damage in hippocampal CA1 is dependent on glutamate release and intact innervation from CA3 .
2893832	0	glutamate	58,67	CA3	92,95	glutamate	CA3	CHEBI:29987	54232(Tax:10116)	Chemical	Gene	microapplication|amod|START_ENTITY studied|nmod|microapplication studied|nmod|area area|compound|END_ENTITY	Characteristics of local excitatory circuits studied with glutamate microapplication in the CA3 area of rat hippocampal slices .
7536248	0	glutamate	10,19	CA3	57,60	glutamate	CA3	CHEBI:29987	54232(Tax:10116)	Chemical	Gene	channels|amod|START_ENTITY hippocampal|nsubj|channels hippocampal|dobj|neurons neurons|compound|END_ENTITY	Dendritic glutamate receptor channels in rat hippocampal CA3 and CA1 pyramidal neurons .
7643157	0	glutamate	71,80	CA3	107,110	glutamate	CA3	CHEBI:29987	54232(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY activation|nmod|receptors produced|nmod|activation produced|nmod|neurons neurons|compound|END_ENTITY	Persistent current oscillations produced by activation of metabotropic glutamate receptors in immature rat CA3 hippocampal neurons .
8014895	0	glutamate	48,57	CA3	90,93	glutamate	CA3	CHEBI:29987	54232(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|nmod|cells cells|compound|END_ENTITY	Reduction of resting K + current by metabotropic glutamate and muscarinic receptors in rat CA3 cells : mediation by G-proteins .
8101227	0	glutamate	26,35	CA3	49,52	glutamate	CA3	CHEBI:29987	54232(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|nmod|END_ENTITY	Heterogeneity of synaptic glutamate receptors on CA3 stratum radiatum interneurones of rat hippocampus .
8103203	0	glutamate	41,50	CA3	87,90	glutamate	CA3	CHEBI:29987	54232(Tax:10116)	Chemical	Gene	receptor-binding|amod|START_ENTITY receptor-binding|nmod|area area|compound|END_ENTITY	A single social stress-experience alters glutamate receptor-binding in rat hippocampal CA3 area .
8613741	0	glutamate	77,86	CA3	41,44	glutamate	CA3	CHEBI:29987	54232(Tax:10116)	Chemical	Gene	activation|compound|START_ENTITY induced|nmod|activation induced|nsubj|oscillations oscillations|nmod|neurons neurons|compound|END_ENTITY	Synchronized oscillations in hippocampal CA3 neurons induced by metabotropic glutamate receptor activation .
8680866	0	glutamate	31,40	CA3	74,77	glutamate	CA3	CHEBI:29987	54232(Tax:10116)	Chemical	Gene	responses|compound|START_ENTITY components|nmod|responses dissociated|nsubj|components dissociated|dobj|neurons neurons|nummod|END_ENTITY	Two components of metabotropic glutamate responses in acutely dissociated CA3 pyramidal neurons of the rat .
8817560	0	glutamate	35,44	CA3	68,71	glutamate	CA3	CHEBI:29987	54232(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|subregion subregion|compound|END_ENTITY	Domoic_acid induces the release of glutamate in the rat hippocampal CA3 subregion .
9137609	0	glutamate	13,22	CA3	67,70	glutamate	CA3	CHEBI:29987	54232(Tax:10116)	Chemical	Gene	response|compound|START_ENTITY dissociated|nsubj|response dissociated|dobj|neurons neurons|compound|END_ENTITY	Metabotropic glutamate response in acutely dissociated hippocampal CA3 neurons of the rat .
9685600	0	glutamate	25,34	CA3	70,73	glutamate	CA3	CHEBI:29987	54232(Tax:10116)	Chemical	Gene	Changes|nmod|START_ENTITY Changes|nmod|END_ENTITY	Changes in extracellular glutamate and GABA levels in the hippocampal CA3 and CA1 areas and the induction of glutamic_acid decarboxylase-67 in dentate granule cells of rats treated with kainic_acid .
12111798	0	glutamate	85,94	COX-2	54,59	glutamate	COX-2	CHEBI:29987	26198(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Secretory phospholipase A -LRB- 2 -RRB- induces delayed neuronal COX-2 expression compared with glutamate .
12132589	0	glutamate	39,48	Ca1	92,95	glutamate	Ca1	CHEBI:29987	759	Chemical	Gene	expressions|amod|START_ENTITY expressions|nmod|area area|amod|END_ENTITY	Oxidative DNA damage and alteration of glutamate transporter expressions in the hippocampal Ca1 area immediately after ischemic insult .
698370	0	glutamate	47,56	Ca2	11,14	glutamate	Ca2	CHEBI:29987	54231(Tax:10116)	Chemical	Gene	oxidation|amod|START_ENTITY END_ENTITY|nmod|oxidation	-LSB- Effect of Ca2 + and gamma-aminobutyric_acid on glutamate and glutamine oxidation by rat brain synaptosomes -RSB- .
26116817	0	glutamate	25,34	CaMKII	72,78	glutamate	CaMKII	D018698	818	Chemical	Gene	START_ENTITY|nmod|receptors receptors|compound|END_ENTITY	Interferon-b1a modulates glutamate neurotransmission in the CNS through CaMKII and GluN2A-containing NMDA receptors .
18715999	0	glutamate	69,78	Calmodulin	0,10	glutamate	Calmodulin	D018698	808	Chemical	Gene	mGluR5|amod|START_ENTITY trafficking|nmod|mGluR5 regulates|dobj|trafficking regulates|nsubj|END_ENTITY	Calmodulin dynamically regulates the trafficking of the metabotropic glutamate receptor mGluR5 .
26864654	0	glutamate	51,60	Calmodulin	0,10	glutamate	Calmodulin	D018698	12314(Tax:10090)	Chemical	Gene	transduction|amod|START_ENTITY regulates|dobj|transduction regulates|nsubj|activity activity|compound|END_ENTITY	Calmodulin activity regulates group I metabotropic glutamate receptor-mediated signal transduction and synaptic_depression .
11597762	0	glutamate	84,93	Caspase-3	0,9	glutamate	Caspase-3	CHEBI:29987	12367(Tax:10090)	Chemical	Gene	excitotoxicity|amod|START_ENTITY neurons|nmod|excitotoxicity neurons|nsubj|activation activation|amod|END_ENTITY	Caspase-3 activation and DNA fragmentation in primary hippocampal neurons following glutamate excitotoxicity .
16567804	0	glutamate	38,47	Caspase-3	0,9	glutamate	Caspase-3	CHEBI:29987	836	Chemical	Gene	EAAT2|amod|START_ENTITY cleaves|dobj|EAAT2 cleaves|nsubj|END_ENTITY	Caspase-3 cleaves and inactivates the glutamate transporter EAAT2 .
20392936	0	glutamate	28,37	Cholecystokinin	0,15	glutamate	Cholecystokinin	CHEBI:29987	885	Chemical	Gene	release|amod|START_ENTITY facilitates|dobj|release facilitates|nsubj|END_ENTITY	Cholecystokinin facilitates glutamate release by increasing the number of readily releasable vesicles and releasing probability .
10821630	0	glutamate	35,44	DmGluRA	0,7	glutamate	DmGluRA	CHEBI:29987	43838(Tax:7227)	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|appos|receptor	DmGluRA , a Drosophila metabotropic glutamate receptor , activates G-protein inwardly rectifying potassium channels in Xenopus oocytes .
7536611	0	glutamate	85,94	EAA4	72,76	glutamate	EAA4	CHEBI:29987	2898	Chemical	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Functional expression and pharmacological characterization of the human EAA4 -LRB- GluR6 -RRB- glutamate receptor : a kainate selective channel subunit .
10612629	0	glutamate	29,38	EAAC1	23,28	glutamate	EAAC1	CHEBI:29987	25550(Tax:10116)	Chemical	Gene	transporter|amod|START_ENTITY transporter|nummod|END_ENTITY	Compensatory change in EAAC1 glutamate transporter in rat hippocampus CA1 region during kindling epileptogenesis .
10671571	0	glutamate	110,119	EAAC1	93,98	glutamate	EAAC1	CHEBI:29987	6505	Chemical	Gene	transporter|amod|START_ENTITY subtype|nmod|transporter subtype|compound|END_ENTITY	Platelet-derived growth factor rapidly increases activity and cell surface expression of the EAAC1 subtype of glutamate transporter through activation of phosphatidylinositol 3-kinase .
11242046	0	glutamate	27,36	EAAC1	49,54	glutamate	EAAC1	CHEBI:29987	6505	Chemical	Gene	transporter|compound|START_ENTITY Modulation|nmod|transporter END_ENTITY|nsubj|Modulation	Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18 .
11406296	0	glutamate	80,89	EAAC1	74,79	glutamate	EAAC1	CHEBI:29987	25550(Tax:10116)	Chemical	Gene	subtypes|amod|START_ENTITY subtypes|compound|END_ENTITY	Amphetamine administration does not alter protein levels of the GLT-1 and EAAC1 glutamate transporter subtypes in rat midbrain , nucleus accumbens , striatum , or prefrontal cortex .
11513867	0	glutamate	85,94	EAAC1	51,56	glutamate	EAAC1	CHEBI:29987	6505	Chemical	Gene	transport|amod|START_ENTITY direction|nmod|transport depends|nmod|direction depends|nsubj|conductance conductance|nmod|END_ENTITY	The anion conductance of the glutamate transporter EAAC1 depends on the direction of glutamate transport .
12123836	0	glutamate	46,55	EAAC1	40,45	glutamate	EAAC1	CHEBI:29987	6505	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Cytoskeleton-related trafficking of the EAAC1 glutamate transporter after activation of the G -LRB- q/11 -RRB- - coupled neurotensin receptor NTS1 .
12237337	0	glutamate	27,36	EAAC1	82,87	glutamate	EAAC1	CHEBI:29987	6505	Chemical	Gene	transporter|compound|START_ENTITY Regulation|nmod|transporter amino_acid|nsubj|Regulation amino_acid|dobj|carrier-1 carrier-1|appos|END_ENTITY	Regulation of the neuronal glutamate transporter excitatory amino_acid carrier-1 -LRB- EAAC1 -RRB- by different protein_kinase_C subtypes .
12242481	0	glutamate	42,51	EAAC1	65,70	glutamate	EAAC1	CHEBI:29987	25550(Tax:10116)	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Localization and possible function of the glutamate transporter , EAAC1 , in the rat retina .
15197183	0	glutamate	34,43	EAAC1	57,62	glutamate	EAAC1	CHEBI:29987	6505	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Rapid trafficking of the neuronal glutamate transporter , EAAC1 : evidence for distinct trafficking pathways differentially regulated by protein_kinase_C and platelet-derived growth factor .
16128593	0	glutamate	27,36	EAAC1	49,54	glutamate	EAAC1	CHEBI:29987	6505	Chemical	Gene	homotrimer|amod|START_ENTITY homotrimer|compound|END_ENTITY	Individual subunits of the glutamate transporter EAAC1 homotrimer function independently of each other .
16182322	0	glutamate	129,138	EAAC1	152,157	glutamate	EAAC1	CHEBI:29987	6505	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Evidence that Akt mediates platelet-derived growth factor-dependent increases in activity and surface expression of the neuronal glutamate transporter , EAAC1 .
16360273	0	glutamate	25,34	EAAC1	47,52	glutamate	EAAC1	CHEBI:29987	25550(Tax:10116)	Chemical	Gene	nerve_injury|compound|START_ENTITY nerve_injury|compound|END_ENTITY	Downregulation of spinal glutamate transporter EAAC1 following nerve_injury is regulated by central glucocorticoid receptors in rats .
16368696	0	glutamate	48,57	EAAC1	71,76	glutamate	EAAC1	CHEBI:29987	6505	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	A carboxyl-terminal determinant of the neuronal glutamate transporter , EAAC1 , is required for platelet-derived growth factor-dependent trafficking .
16882010	0	glutamate	18,27	EAAC1	40,45	glutamate	EAAC1	CHEBI:29987	25550(Tax:10116)	Chemical	Gene	transporter|amod|START_ENTITY Regulation|nmod|transporter END_ENTITY|nsubj|Regulation	Regulation of the glutamate transporter EAAC1 by expression and activation of delta-opioid receptor .
16959903	0	glutamate	77,86	EAAC1	46,51	glutamate	EAAC1	CHEBI:29987	6505	Chemical	Gene	transport|amod|START_ENTITY inhibition|nmod|transport leading|nmod|inhibition endocytic|acl|leading endocytic|nmod|END_ENTITY	Syntaxin_1A promotes the endocytic sorting of EAAC1 leading to inhibition of glutamate transport .
17630698	0	glutamate	47,56	EAAC1	100,105	glutamate	EAAC1	CHEBI:29987	6505	Chemical	Gene	translocation|amod|START_ENTITY associated|nmod|translocation associated|nmod|END_ENTITY	Two conformational changes are associated with glutamate translocation by the glutamate transporter EAAC1 .
18207650	0	glutamate	64,73	EAAC1	119,124	glutamate	EAAC1	CHEBI:29987	25550(Tax:10116)	Chemical	Gene	transporter|amod|START_ENTITY transporter|acl|amino_acid amino_acid|dobj|carrier carrier|appos|END_ENTITY	C6 glioma cells differentiated by retinoic_acid overexpress the glutamate transporter excitatory amino_acid carrier 1 -LRB- EAAC1 -RRB- .
18684713	0	glutamate	25,34	EAAC1	47,52	glutamate	EAAC1	CHEBI:29987	25550(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY Modulation|nmod|transporter END_ENTITY|nsubj|Modulation	Modulation of the neural glutamate transporter EAAC1 by the addicsin-interacting protein ARL6IP1 .
19605734	0	glutamate	55,64	EAAC1	49,54	glutamate	EAAC1	CHEBI:29987	403751(Tax:9615)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	PKC induces internalization and retention of the EAAC1 glutamate transporter in recycling endosomes of MDCK cells .
21185901	0	glutamate	30,39	EAAC1	13,18	glutamate	EAAC1	CHEBI:29987	25550(Tax:10116)	Chemical	Gene	transporter|amod|START_ENTITY subtype|nmod|transporter subtype|compound|END_ENTITY	mRNA for the EAAC1 subtype of glutamate transporter is present in neuronal dendrites in vitro and dramatically increases in vivo after a seizure .
22285253	0	glutamate	62,71	EAAC1	44,49	glutamate	EAAC1	CHEBI:29987	6505	Chemical	Gene	reuptake|amod|START_ENTITY expression|amod|reuptake expression|nummod|END_ENTITY	Transient striatal GLT-1 blockade increases EAAC1 expression , glutamate reuptake , and decreases tyrosine hydroxylase phosphorylation at ser -LRB- 19 -RRB- .
22539860	0	glutamate	29,38	EAAC1	15,20	glutamate	EAAC1	CHEBI:29987	6505	Chemical	Gene	START_ENTITY|nsubj|density density|nmod|END_ENTITY	The density of EAAC1 -LRB- EAAT3 -RRB- glutamate transporters expressed by neurons in the mammalian CNS .
22703277	0	glutamate	95,104	EAAC1	53,58	glutamate	EAAC1	CHEBI:29987	6505	Chemical	Gene	analogue|amod|START_ENTITY Mechanism|nmod|analogue Mechanism|nmod|END_ENTITY	Mechanism of inhibition of the glutamate transporter EAAC1 by the conformationally constrained glutamate analogue -LRB- + -RRB- - HIP-B .
24334055	0	glutamate	33,42	EAAC1	56,61	glutamate	EAAC1	D018698	20510(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Genetic deletion of the neuronal glutamate transporter , EAAC1 , results in decreased_neuronal_death after pilocarpine-induced status_epilepticus .
25350110	3	glutamate	344,353	EAAC1	313,318	glutamate	EAAC1	CHEBI:29987	20510(Tax:10090)	Chemical	Gene	transporter|amod|START_ENTITY described|nmod|transporter described|nsubjpass|END_ENTITY	EAAC1 was first described as a glutamate transporter but later recognized to also function as a cysteine transporter in neurons .
25515313	0	glutamate	137,146	EAAC1	37,42	glutamate	EAAC1	CHEBI:29987	25550(Tax:10116)	Chemical	Gene	clearance|amod|START_ENTITY role|nmod|clearance suggests|dobj|role amino_acid|parataxis|suggests amino_acid|dobj|carrier carrier|appos|END_ENTITY	The excitatory amino_acid carrier 1 -LRB- EAAC1 -RRB- in the rat nucleus of the solitary tract : subcellular localization suggests no major role in glutamate clearance .
26092725	0	glutamate	22,31	EAAC1	88,93	glutamate	EAAC1	D018698	20510(Tax:10090)	Chemical	Gene	uptake|amod|START_ENTITY controls|dobj|uptake amino_acid|dep|controls amino_acid|nsubj|carrier carrier|appos|END_ENTITY	Neuregulin_1 controls glutamate uptake by upregulating excitatory amino_acid carrier 1 -LRB- EAAC1 -RRB- .
8643086	0	glutamate	28,37	EAAC1	149,154	glutamate	EAAC1	CHEBI:29987	25550(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY Comparison|dep|activity amino_acid|nsubj|Comparison amino_acid|dobj|carrier carrier|appos|END_ENTITY	Comparison of Na + - dependent glutamate transport activity in synaptosomes , C6_glioma , and Xenopus oocytes expressing excitatory amino_acid carrier 1 -LRB- EAAC1 -RRB- .
8717355	0	glutamate	29,38	EAAC1	23,28	glutamate	EAAC1	CHEBI:29987	25550(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|variation variation|nmod|END_ENTITY	Circadian variation of EAAC1 glutamate transporter messenger RNA in the rat suprachiasmatic nuclei .
8817573	0	glutamate	53,62	EAAC1	76,81	glutamate	EAAC1	CHEBI:29987	25550(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Immunocytochemical localization of the high-affinity glutamate transporter , EAAC1 , in the retina of representative vertebrate species .
9542890	0	glutamate	23,32	EAAC1	0,5	glutamate	EAAC1	CHEBI:29987	25550(Tax:10116)	Chemical	Gene	tranporter|compound|START_ENTITY END_ENTITY|appos|tranporter	EAAC1 , a high-affinity glutamate tranporter , is localized to astrocytes and gabaergic neurons besides pyramidal cells in the rat cerebral cortex .
11730698	0	glutamate	14,23	EAAT1	38,43	glutamate	EAAT1	CHEBI:29987	6507	Chemical	Gene	transporters|amod|START_ENTITY transporters|dep|END_ENTITY	Na + dependent glutamate transporters -LRB- EAAT1 , EAAT2 , and EAAT3 -RRB- in primary astrocyte cultures : effect of oxidative stress .
11784698	0	glutamate	22,31	EAAT1	91,96	glutamate	EAAT1	CHEBI:29987	6507	Chemical	Gene	transporter|amod|START_ENTITY expression|nmod|transporter amino_acid|nsubj|expression amino_acid|dobj|1 1|appos|END_ENTITY	The expression of the glutamate re-uptake transporter excitatory amino_acid transporter 1 -LRB- EAAT1 -RRB- in the normal human CNS and in motor_neurone_disease : an immunohistochemical study .
11826152	0	glutamate	27,36	EAAT1	86,91	glutamate	EAAT1	CHEBI:29987	6507	Chemical	Gene	transporter|amod|START_ENTITY expression|nmod|transporter amino_acid|nsubj|expression amino_acid|dobj|1 1|appos|END_ENTITY	Aberrant expression of the glutamate transporter excitatory amino_acid transporter 1 -LRB- EAAT1 -RRB- in Alzheimer 's _ disease .
12911626	0	glutamate	198,207	EAAT1	40,45	glutamate	EAAT1	CHEBI:29987	398856(Tax:8355)	Chemical	Gene	EAAT1|amod|START_ENTITY expression|nmod|EAAT1 stimulated|nsubjpass|expression Surface|acl:relcl|stimulated isoforms|dobj|Surface isoforms|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of the glutamate transporter EAAT1 by the ubiquitin ligase Nedd4-2 and the serum and glucocorticoid-inducible kinase isoforms SGK1/3 and protein kinase B. Surface expression of the glial glutamate transporter EAAT1 is stimulated by insulin-like growth factor 1 through activation of phosphatidylinositol-3-kinase .
14994336	0	glutamate	74,83	EAAT1	122,127	glutamate	EAAT1	CHEBI:29987	20512(Tax:10090)	Chemical	Gene	transporters|amod|START_ENTITY ligand|nmod|transporters Binding|appos|ligand demonstrate|nsubj|Binding demonstrate|xcomp|labeling labeling|nmod|END_ENTITY	Binding and transport of -LSB- 3H -RSB- -LRB- 2S ,4 R -RRB- - _ 4-methylglutamate , a new ligand for glutamate transporters , demonstrate labeling of EAAT1 in cultured murine astrocytes .
15565490	0	glutamate	27,36	EAAT1	50,55	glutamate	EAAT1	D018698	20512(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY transporters|nsubj|expression transporters|dobj|END_ENTITY	Differential expression of glutamate transporters EAAT1 and EAAT2 in mice deficient for PACAP-type_I_receptor .
16877378	0	glutamate	65,74	EAAT1	88,93	glutamate	EAAT1	CHEBI:29987	6507	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Structural rearrangements at the translocation pore of the human glutamate transporter , EAAT1 .
17428968	3	glutamate	386,395	EAAT1	446,451	glutamate	EAAT2	CHEBI:29987	6506	Chemical	Gene	transporters|compound|START_ENTITY -RSB-|dep|transporters -RSB-|appos|END_ENTITY	Here , we investigate the effect of hypoxia on activity and expression of the key glutamate transporters excitatory amino_acid transporter 1 -LRB- EAAT1 -RRB- -LSB- GLAST -LRB- glutamate-aspartate_transporter -RRB- -RSB- and EAAT2 -LSB- GLT-1 -LRB- glutamate_transporter_1 -RRB- -RSB- .
17990250	0	glutamate	29,38	EAAT1	51,56	glutamate	EAAT1	CHEBI:29987	6507	Chemical	Gene	modeling|nmod|START_ENTITY transporter|nsubj|modeling transporter|dobj|END_ENTITY	Fragmental modeling of human glutamate transporter EAAT1 and analysis of its binding modes by docking and pharmacophore mapping .
19078949	0	glutamate	14,23	EAAT1	43,48	glutamate	EAAT1	CHEBI:29987	20512(Tax:10090)	Chemical	Gene	GLAST|amod|START_ENTITY GLAST|appos|END_ENTITY	Assessment of glutamate transporter GLAST -LRB- EAAT1 -RRB- - deficient mice for phenotypes relevant to the negative and executive/cognitive symptoms of schizophrenia .
19139306	0	glutamate	63,72	EAAT1	32,37	glutamate	EAAT1	CHEBI:29987	6507	Chemical	Gene	reuptake|amod|START_ENTITY affecting|dobj|reuptake C186S|acl|affecting C186S|compound|END_ENTITY	Episodic_ataxia associated with EAAT1 mutation C186S affecting glutamate reuptake .
20477940	0	glutamate	95,104	EAAT1	118,123	glutamate	EAAT1	CHEBI:29987	6507	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	The position of an arginine residue influences substrate affinity and K + coupling in the human glutamate transporter , EAAT1 .
22427946	0	glutamate	80,89	EAAT1	103,108	glutamate	EAAT1	CHEBI:29987	6507	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Position of the third Na + site in the aspartate transporter GltPh and the human glutamate transporter , EAAT1 .
25152321	0	glutamate	31,40	EAAT1	54,59	glutamate	EAAT1	CHEBI:29987	20512(Tax:10090)	Chemical	Gene	inhibitions|nmod|START_ENTITY transporters|nsubj|inhibitions transporters|dobj|transport transport|compound|END_ENTITY	Pharmacological inhibitions of glutamate transporters EAAT1 and EAAT2 compromise glutamate transport in photoreceptor to ON-bipolar cell synapses .
25152321	0	glutamate	81,90	EAAT1	54,59	glutamate	EAAT1	CHEBI:29987	20512(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY transport|compound|END_ENTITY	Pharmacological inhibitions of glutamate transporters EAAT1 and EAAT2 compromise glutamate transport in photoreceptor to ON-bipolar cell synapses .
9614067	0	glutamate	50,59	EAAT1	73,78	glutamate	EAAT1	CHEBI:29987	6507	Chemical	Gene	domains|nmod|START_ENTITY Identification|nmod|domains transporters|nsubj|Identification transporters|dobj|END_ENTITY	Identification of functional domains of the human glutamate transporters EAAT1 and EAAT2 .
9658205	5	glutamate	637,646	EAAT1	660,665	glutamate	EAAT2	CHEBI:29987	6506	Chemical	Gene	transport|amod|START_ENTITY transport|nmod|END_ENTITY	Zn2 + is a noncompetitive , partial inhibitor of glutamate transport by EAAT1 with an IC50 value of 9.9 + / - 2.3 microM and has no effect on glutamate transport by EAAT2 at concentrations up to 300 microM .
10098717	0	glutamate	31,40	EAAT2	76,81	glutamate	EAAT2	CHEBI:29987	6506	Chemical	Gene	transporters|compound|START_ENTITY family|nmod|transporters family|dep|focus focus|nmod|subtype subtype|compound|END_ENTITY	The family of sodium-dependent glutamate transporters : a focus on the GLT-1 / EAAT2 subtype .
11204345	0	glutamate	25,34	EAAT2	47,52	glutamate	EAAT2	CHEBI:29987	6506	Chemical	Gene	transporter|amod|START_ENTITY variation|nmod|transporter END_ENTITY|nsubj|variation	Genetic variation of the glutamate transporter EAAT2 gene and vulnerability to alcohol_dependence .
12153483	0	glutamate	60,69	EAAT2	54,59	glutamate	EAAT2	CHEBI:29987	20511(Tax:10090)	Chemical	Gene	transporter|amod|START_ENTITY END_ENTITY|dobj|transporter	Alternative splicing of the 5 ' - sequences of the mouse EAAT2 glutamate transporter and expression in a transgenic model for amyotrophic_lateral_sclerosis .
12558972	0	glutamate	12,21	EAAT2	35,40	glutamate	EAAT2	CHEBI:29987	6506	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	The ` glial ' glutamate transporter , EAAT2 -LRB- Glt-1 -RRB- accounts for high affinity glutamate uptake into adult rodent nerve endings .
12558972	0	glutamate	76,85	EAAT2	35,40	glutamate	EAAT2	CHEBI:29987	6506	Chemical	Gene	uptake|compound|START_ENTITY accounts|nmod|uptake accounts|nsubj|transporter transporter|appos|END_ENTITY	The ` glial ' glutamate transporter , EAAT2 -LRB- Glt-1 -RRB- accounts for high affinity glutamate uptake into adult rodent nerve endings .
12578975	0	glutamate	14,23	EAAT2	131,136	glutamate	EAAT2	CHEBI:29987	6506	Chemical	Gene	regulation|amod|START_ENTITY Insights|nmod|regulation Insights|dep|cloning cloning|nmod|promoter promoter|nmod|transporter transporter|appos|END_ENTITY	Insights into glutamate transport regulation in human astrocytes : cloning of the promoter for excitatory amino_acid transporter 2 -LRB- EAAT2 -RRB- .
12614333	0	glutamate	4,13	EAAT2	27,32	glutamate	EAAT2	CHEBI:29987	20511(Tax:10090)	Chemical	Gene	transporters|nsubj|START_ENTITY transporters|ccomp|mediate mediate|nsubj|END_ENTITY	The glutamate transporters EAAT2 and EAAT3 mediate cysteine uptake in cortical neuron cultures .
15246112	0	glutamate	24,33	EAAT2	46,51	glutamate	EAAT2	CHEBI:29987	6506	Chemical	Gene	RNA|amod|START_ENTITY RNA|compound|END_ENTITY	Alternative splicing of glutamate transporter EAAT2 RNA in neocortex and hippocampus of temporal_lobe_epilepsy patients .
15869527	0	glutamate	35,44	EAAT2	29,34	glutamate	EAAT2	CHEBI:29987	6506	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Over-expression of the human EAAT2 glutamate transporter within neurons of mouse organotypic hippocampal slice cultures leads to increased vulnerability of CA1 pyramidal cells .
16137792	0	glutamate	20,29	EAAT2	117,122	glutamate	EAAT2	CHEBI:29987	6506	Chemical	Gene	uptake|compound|START_ENTITY mediated|nsubj|uptake mediated|nmod|END_ENTITY	Thrombin-stimulated glutamate uptake in human platelets is predominantly mediated by the glial glutamate transporter EAAT2 .
16520390	0	glutamate	63,72	EAAT2	22,27	glutamate	EAAT2	CHEBI:29987	6506	Chemical	Gene	concentrations|compound|START_ENTITY associated|nmod|concentrations associated|nsubjpass|polymorphism polymorphism|nmod|promoter promoter|compound|END_ENTITY	A polymorphism in the EAAT2 promoter is associated with higher glutamate concentrations and higher frequency of progressing stroke .
16573655	0	glutamate	25,34	EAAT2	127,132	glutamate	EAAT2	CHEBI:29987	6506	Chemical	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|dep|evidence evidence|nmod|effect effect|nmod|subtype subtype|compound|END_ENTITY	Regulation of astrocytic glutamate transporter expression by Akt : evidence for a selective transcriptional effect on the GLT-1 / EAAT2 subtype .
17138558	0	glutamate	31,40	EAAT2	53,58	glutamate	EAAT2	CHEBI:29987	20511(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Translational control of glial glutamate transporter EAAT2 expression .
17311293	0	glutamate	49,58	EAAT2	71,76	glutamate	EAAT2	CHEBI:29987	6506	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	DNA methylation dependent silencing of the human glutamate transporter EAAT2 gene in glial cells .
17311293	2	glutamate	360,369	EAAT2	295,300	glutamate	EAAT2	CHEBI:29987	6506	Chemical	Gene	quantity|nmod|START_ENTITY uptake|nmod|quantity carry|dobj|uptake thought|xcomp|carry thought|nsubjpass|END_ENTITY	The astroglial glutamate transporter EAAT2 is thought to carry out the uptake of the vast quantity of glutamate , and dysregulation of EAAT2 expression is involved in the pathogenesis of neurological_disorders with marked excitotoxic components .
17663137	3	glutamate	420,429	EAAT2	463,468	glutamate	GLAST	CHEBI:29987	20512(Tax:10090)	Chemical	Gene	transporters|compound|START_ENTITY transporters|dep|GLT-1 GLT-1|dep|END_ENTITY	In the CNS , five distinct glutamate transporters -LRB- GLAST/EAAT1 , GLT-1 / EAAT2 , EAAC1/EAAT3 , EAAT4 and EAAT5 -RRB- have been cloned .
18378006	0	glutamate	49,58	EAAT2	18,23	glutamate	EAAT2	CHEBI:29987	6506	Chemical	Gene	concentration|compound|START_ENTITY polymorphism|nmod|concentration polymorphism|nsubj|Association Association|nmod|END_ENTITY	Association of an EAAT2 polymorphism with higher glutamate concentration in relapsing multiple_sclerosis .
18805467	0	glutamate	29,38	EAAT2	173,178	glutamate	EAAT2	CHEBI:29987	20511(Tax:10090)	Chemical	Gene	assessment|nmod|START_ENTITY uptake|nsubj|assessment uptake|parataxis|amino_acid amino_acid|dobj|2 2|appos|END_ENTITY	A quantitative assessment of glutamate uptake into hippocampal synaptic terminals and astrocytes : new insights into a neuronal role for excitatory amino_acid transporter 2 -LRB- EAAT2 -RRB- .
18805467	3	glutamate	712,721	EAAT2	706,711	glutamate	EAAT2	CHEBI:29987	20511(Tax:10090)	Chemical	Gene	mice|amod|START_ENTITY mice|nummod|END_ENTITY	About 3/4 of all terminals in the stratum radiatum CA1 accumulated d-aspartate-immunoreactivity by an active dihydrokainate-sensitive mechanism which was absent in EAAT2 glutamate transporter knockout mice .
18838545	0	glutamate	80,89	EAAT2	119,124	glutamate	EAAT2	CHEBI:29987	6506	Chemical	Gene	transport|amod|START_ENTITY impair|dobj|transport impair|nmod|END_ENTITY	Aquaporin-4-binding autoantibodies in patients with neuromyelitis_optica impair glutamate transport by down-regulating EAAT2 .
19023027	0	glutamate	16,25	EAAT2	38,43	glutamate	EAAT2	CHEBI:29987	20511(Tax:10090)	Chemical	Gene	START_ENTITY|ccomp|reduces reduces|nsubj|expression expression|compound|END_ENTITY	Increased glial glutamate transporter EAAT2 expression reduces visceral nociceptive response in mice .
19747495	0	glutamate	22,31	EAAT2	53,58	glutamate	EAAT2	CHEBI:29987	29482(Tax:10116)	Chemical	Gene	transporters|amod|START_ENTITY expression|nmod|transporters vGluT1|nsubj|expression Reduced|xcomp|vGluT1 learned|ccomp|Reduced learned|nsubj|END_ENTITY	Reduced expression of glutamate transporters vGluT1 , EAAT2 and EAAT4 in learned helpless rats , an animal model of depression .
20193040	0	glutamate	83,92	EAAT2	105,110	glutamate	EAAT2	CHEBI:29987	6506	Chemical	Gene	association|compound|START_ENTITY association|compound|END_ENTITY	Increased expression of cholesterol 24S-hydroxylase results in disruption of glial glutamate transporter EAAT2 association with lipid rafts : a potential role in Alzheimer 's _ disease .
20807794	0	glutamate	5,14	EAAT2	26,31	glutamate	EAAT2	CHEBI:29987	6506	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|END_ENTITY	Fast glutamate uptake via EAAT2 shapes the cone-mediated light offset response in bipolar_cells .
22513140	0	glutamate	16,25	EAAT2	38,43	glutamate	EAAT2	CHEBI:29987	20511(Tax:10090)	Chemical	Gene	START_ENTITY|ccomp|reduces reduces|nsubj|expression expression|compound|END_ENTITY	Increased glial glutamate transporter EAAT2 expression reduces epileptogenic processes following pilocarpine-induced status_epilepticus .
24076156	0	glutamate	10,19	EAAT2	32,37	glutamate	EAAT2	CHEBI:29987	6506	Chemical	Gene	variants|amod|START_ENTITY variants|compound|END_ENTITY	Effect of glutamate transporter EAAT2 gene variants and gray matter_deficits_on_working_memory in schizophrenia .
24224925	0	glutamate	26,35	EAAT2	11,16	glutamate	EAAT2	CHEBI:29987	20511(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|GLT-1 GLT-1|appos|END_ENTITY	The GLT-1 -LRB- EAAT2 ; slc1a2 -RRB- glutamate transporter is essential for glutamate homeostasis in the neocortex of the mouse .
24224925	0	glutamate	65,74	EAAT2	11,16	glutamate	EAAT2	CHEBI:29987	20511(Tax:10090)	Chemical	Gene	homeostasis|amod|START_ENTITY essential|nmod|homeostasis glutamate|ccomp|essential glutamate|nsubj|GLT-1 GLT-1|appos|END_ENTITY	The GLT-1 -LRB- EAAT2 ; slc1a2 -RRB- glutamate transporter is essential for glutamate homeostasis in the neocortex of the mouse .
24280215	0	glutamate	56,65	EAAT2	113,118	glutamate	EAAT2	CHEBI:29987	20511(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY analysis|nmod|transporter provide|nsubj|analysis provide|dobj|evidence evidence|nmod|role role|nmod|END_ENTITY	Proteome analysis and conditional deletion of the EAAT2 glutamate transporter provide evidence against a role of EAAT2 in pancreatic insulin secretion in mice .
24280215	0	glutamate	56,65	EAAT2	50,55	glutamate	EAAT2	CHEBI:29987	20511(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Proteome analysis and conditional deletion of the EAAT2 glutamate transporter provide evidence against a role of EAAT2 in pancreatic insulin secretion in mice .
24569372	0	glutamate	28,37	EAAT2	50,55	glutamate	EAAT2	CHEBI:29987	20511(Tax:10090)	Chemical	Gene	translation|amod|START_ENTITY translation|compound|END_ENTITY	Small-molecule activator of glutamate transporter EAAT2 translation provides neuroprotection .
26046374	0	glutamate	113,122	EAAT2	172,177	glutamate	EAAT2	D018698	6506	Chemical	Gene	transporter|amod|START_ENTITY expression|nmod|transporter amino_acid|nsubj|expression amino_acid|dobj|2 2|appos|END_ENTITY	The peroxisome_proliferator_activated_receptor_gamma agonist pioglitazone increases functional expression of the glutamate transporter excitatory amino_acid transporter 2 -LRB- EAAT2 -RRB- in human glioblastoma cells .
9539131	0	glutamate	86,95	EAAT2	77,82	glutamate	EAAT2	CHEBI:29987	6506	Chemical	Gene	transporter|amod|START_ENTITY END_ENTITY|appos|transporter	Aberrant RNA processing in a neurodegenerative_disease : the cause for absent EAAT2 , a glutamate transporter , in amyotrophic_lateral_sclerosis .
9585360	0	glutamate	17,26	EAAT2	39,44	glutamate	EAAT2	CHEBI:29987	6506	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Mutations in the glutamate transporter EAAT2 gene do not cause abnormal EAAT2 transcripts in amyotrophic_lateral_sclerosis .
9585360	0	glutamate	17,26	EAAT2	72,77	glutamate	EAAT2	CHEBI:29987	6506	Chemical	Gene	gene|amod|START_ENTITY Mutations|nmod|gene cause|nsubj|Mutations cause|dobj|transcripts transcripts|compound|END_ENTITY	Mutations in the glutamate transporter EAAT2 gene do not cause abnormal EAAT2 transcripts in amyotrophic_lateral_sclerosis .
9605566	0	glutamate	41,50	EAAT2	64,69	glutamate	EAAT2	CHEBI:29987	6506	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Serine-O-sulphate transport by the human glutamate transporter , EAAT2 .
12119102	0	glutamate	99,108	EAAT3	122,127	glutamate	EAAT3	CHEBI:29987	20510(Tax:10090)	Chemical	Gene	START_ENTITY|dep|interacting interacting|nsubj|transporter transporter|appos|END_ENTITY	Molecular cloning , gene structure , expression profile and functional characterization of the mouse glutamate transporter -LRB- EAAT3 -RRB- interacting protein GTRAP3-18 .
12620282	0	glutamate	36,45	EAAT3	79,84	glutamate	EAAT3	CHEBI:29987	25550(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|expression expression|compound|END_ENTITY	Effects of ammonia on high affinity glutamate uptake and glutamate transporter EAAT3 expression in cultured rat cerebellar granule cells .
16417946	0	glutamate	35,44	EAAT3	29,34	glutamate	EAAT3	CHEBI:29987	25550(Tax:10116)	Chemical	Gene	transporter|amod|START_ENTITY transporter|compound|END_ENTITY	PKC-dependent stimulation of EAAT3 glutamate transporter does not require the integrity of actin cytoskeleton .
17382927	0	glutamate	46,55	EAAT3	68,73	glutamate	EAAT3	CHEBI:29987	25550(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Propofol reverses oxidative stress-attenuated glutamate transporter EAAT3 activity : evidence of protein_kinase_C involvement .
22483750	0	glutamate	18,27	EAAT3	40,45	glutamate	EAAT3	CHEBI:29987	6505	Chemical	Gene	transporter|amod|START_ENTITY Regulation|nmod|transporter END_ENTITY|nsubj|Regulation	Regulation of the glutamate transporter EAAT3 by mammalian_target_of_rapamycin mTOR .
22532568	0	glutamate	106,115	EAAT3	99,104	glutamate	EAAT3	CHEBI:29987	6505	Chemical	Gene	transporters|compound|START_ENTITY transporters|amod|amino_acid amino_acid|dep|END_ENTITY	Neutralizing aspartate 83 modifies substrate translocation of excitatory amino_acid transporter 3 -LRB- EAAT3 -RRB- glutamate transporters .
22539860	0	glutamate	29,38	EAAT3	22,27	glutamate	EAAT3	CHEBI:29987	6505	Chemical	Gene	START_ENTITY|nsubj|density density|appos|END_ENTITY	The density of EAAC1 -LRB- EAAT3 -RRB- glutamate transporters expressed by neurons in the mammalian CNS .
22540959	0	glutamate	24,33	EAAT3	46,51	glutamate	EAAT3	CHEBI:29987	25550(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY Changes|nmod|transporter END_ENTITY|nsubj|Changes	Changes in the neuronal glutamate transporter EAAT3 in rat brain after exposure to methamphetamine .
26253075	0	glutamate	73,82	EAAT3	95,100	glutamate	EAAT3	D018698	25550(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY reduce|dobj|activity reduce|nsubj|END_ENTITY	Doxepin and imipramine but not fluoxetine reduce the activity of the rat glutamate transporter EAAT3 expressed in Xenopus oocytes .
9409715	0	glutamate	56,65	EAAT3	85,90	glutamate	EAAT3	CHEBI:29987	25550(Tax:10116)	Chemical	Gene	EAAC1|amod|START_ENTITY EAAC1|appos|END_ENTITY	Immunohistochemical localization of the neuron-specific glutamate transporter EAAC1 -LRB- EAAT3 -RRB- in rat brain and spinal cord revealed by a novel monoclonal antibody .
11242047	0	glutamate	27,36	EAAT4	49,54	glutamate	EAAT4	CHEBI:29987	6511	Chemical	Gene	transporter|compound|START_ENTITY Modulation|nmod|transporter END_ENTITY|nsubj|Modulation	Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins .
16316976	0	glutamate	4,13	EAAT4	35,40	glutamate	EAAT4	CHEBI:29987	6511	Chemical	Gene	transporter|amod|START_ENTITY subtypes|nsubj|transporter subtypes|dobj|glutamate glutamate|compound|END_ENTITY	The glutamate transporter subtypes EAAT4 and EAATs 1-3 transport glutamate with dramatically different kinetics and voltage dependence but share a common uptake mechanism .
16837599	0	glutamate	35,44	EAAT4	29,34	glutamate	EAAT4	CHEBI:29987	6511	Chemical	Gene	START_ENTITY|nsubj|interactions interactions|nmod|END_ENTITY	Intersubunit interactions in EAAT4 glutamate transporters .
17022974	0	glutamate	50,59	EAAT4	44,49	glutamate	EAAT4	CHEBI:29987	20513(Tax:10090)	Chemical	Gene	reporter|compound|START_ENTITY reporter|compound|END_ENTITY	Analysis of cerebellar Purkinje cells using EAAT4 glutamate transporter promoter reporter in mice generated via bacterial artificial chromosome-mediated transgenesis .
8905715	0	glutamate	25,34	EAAT4	0,5	glutamate	EAAT4	CHEBI:29987	6511	Chemical	Gene	transporter|compound|START_ENTITY transporter|nsubj|END_ENTITY	EAAT4 is a post-synaptic glutamate transporter at Purkinje cell synapses .
9129177	0	glutamate	46,55	EAAT4	68,73	glutamate	EAAT4	CHEBI:29987	20513(Tax:10090)	Chemical	Gene	transporter|amod|START_ENTITY expression|nmod|transporter Changes|nmod|expression END_ENTITY|nsubj|Changes	Changes in expression and distribution of the glutamate transporter EAAT4 in developing mouse Purkinje cells .
9261809	0	glutamate	33,42	EAAT4	55,60	glutamate	EAAT4	CHEBI:29987	20513(Tax:10090)	Chemical	Gene	transporter|amod|START_ENTITY localization|nmod|transporter END_ENTITY|nsubj|localization	Extra-junctional localization of glutamate transporter EAAT4 at excitatory Purkinje cell synapses .
9367257	0	glutamate	16,25	EAAT4	47,52	glutamate	EAAT4	CHEBI:29987	6511	Chemical	Gene	transporter|amod|START_ENTITY Expression|nmod|transporter subtype|nsubj|Expression subtype|advmod|END_ENTITY	Expression of a glutamate transporter subtype , EAAT4 , in the developing human cerebellum .
9838098	0	glutamate	50,59	EAAT4	44,49	glutamate	EAAT4	CHEBI:29987	84012(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|cloning cloning|nmod|END_ENTITY	Molecular cloning and expression of the rat EAAT4 glutamate transporter subtype .
15949387	0	glutamate	97,106	ERK1/2	122,128	glutamate	ERK1/2	CHEBI:29987	50689;116590	Chemical	Gene	induced|nmod|START_ENTITY cell|acl|induced apoptosis|nmod|cell oligodeoxynucleotide|nmod|apoptosis effects|nmod|oligodeoxynucleotide mediated|nsubjpass|effects mediated|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Inhibition effects of par-4 antisense oligodeoxynucleotide on apoptosis of PC12 cell induced by glutamate is mediated by ERK1/2 -RSB- .
16305822	0	glutamate	38,47	ERK1/2	87,93	glutamate	ERK1/2	CHEBI:29987	26417;26413	Chemical	Gene	START_ENTITY|ccomp|activates activates|dobj|END_ENTITY	Stimulation of oncogenic metabotropic glutamate receptor 1 in melanoma cells activates ERK1/2 via PKCepsilon .
21822733	0	glutamate	110,119	ERK1/2	14,20	glutamate	ERK1/2	CHEBI:29987	50689;116590	Chemical	Gene	induced|nmod|START_ENTITY Activation|acl|induced Activation|nmod|END_ENTITY	Activation of ERK1/2 and PI3K/Akt by IGF-1 on GAP-43 expression in DRG neurons with excitotoxicity induced by glutamate in vitro .
23988164	0	glutamate	47,56	ERK1/2	121,127	glutamate	ERK1/2	CHEBI:29987	50689;116590	Chemical	Gene	neurotoxicity|amod|START_ENTITY rescues|dobj|neurotoxicity rescues|nmod|cells cells|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Activation of M1 mAChRs by lesatropane rescues glutamate neurotoxicity in PC12 cells via PKC-mediated phosphorylation of ERK1/2 .
20980602	0	glutamate	17,26	Eaat1	39,44	glutamate	Eaat1	CHEBI:29987	34251(Tax:7227)	Chemical	Gene	START_ENTITY|ccomp|regulated regulated|nsubjpass|END_ENTITY	Drosophila glial glutamate transporter Eaat1 is regulated by fringe-mediated notch signaling and is essential for larval locomotion .
22094018	0	glutamate	24,33	Eaat2b	14,20	glutamate	Eaat2b	CHEBI:29987	560802(Tax:7955)	Chemical	Gene	transporter|amod|START_ENTITY END_ENTITY|appos|transporter	Disruption of Eaat2b , a glutamate transporter , results in abnormal motor behaviors in developing zebrafish .
8910543	0	glutamate	117,126	FAK	109,112	glutamate	FAK	CHEBI:29987	25614(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|cell_adhesion_kinase_beta cell_adhesion_kinase_beta|appos|END_ENTITY	Differential regulation of proline-rich_tyrosine_kinase_2 / cell_adhesion_kinase_beta -LRB- PYK2/CAKbeta -RRB- and pp125 -LRB- FAK -RRB- by glutamate and depolarization in rat hippocampus .
12591163	0	glutamate	114,123	FMRP	45,49	glutamate	FMRP	CHEBI:29987	24948(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY activation|nmod|receptors requires|dobj|activation requires|nsubj|translation translation|nmod|END_ENTITY	Whisker stimulation-dependent translation of FMRP in the barrel cortex requires activation of type I metabotropic glutamate receptors .
18434517	0	glutamate	138,147	FMRP	109,113	glutamate	FMRP	CHEBI:29987	14265(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY kinase|nmod|receptors kinase|dobj|IV IV|nmod|regulation regulation|nmod|END_ENTITY	Roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the regulation of FMRP by group I metabotropic glutamate receptors .
22867433	0	glutamate	64,73	FMRP	35,39	glutamate	FMRP	CHEBI:29987	14265(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY END_ENTITY|nmod|receptors	Roles of CREB in the regulation of FMRP by group I metabotropic glutamate receptors in cingulate cortex .
19665463	0	glutamate	42,51	Fos	35,38	glutamate	Fos	CHEBI:29987	314322(Tax:10116)	Chemical	Gene	neurons|amod|START_ENTITY END_ENTITY|nmod|neurons	Vaginocervical stimulation induces Fos in glutamate neurons in the ventromedial hypothalamus : attenuation by estrogen and progesterone .
21901840	0	glutamate	13,22	Fragile_X_mental_retardation_protein	114,150	glutamate	Fragile X mental retardation protein	CHEBI:29987	2332	Chemical	Gene	associated|dep|START_ENTITY associated|nmod|underexpression underexpression|nmod|END_ENTITY	Metabotropic glutamate receptor 5 upregulation in children with autism is associated with underexpression of both Fragile_X_mental_retardation_protein and GABAA receptor beta 3 in adults with autism .
11677266	0	glutamate	39,48	Fyn	62,65	glutamate	Fyn	CHEBI:29987	2534	Chemical	Gene	receptors|compound|START_ENTITY receptors|nmod|END_ENTITY	Tyrosine phosphorylation of ionotropic glutamate receptors by Fyn or Src differentially modulates their susceptibility to calpain and enhances their binding to spectrin and PSD-95 .
16583206	0	glutamate	110,119	GDH	135,138	glutamate	GDH	CHEBI:29987	2746	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	New insights from X-ray photoelectron spectroscopy into the chemistry of covalent enzyme immobilization , with glutamate dehydrogenase -LRB- GDH -RRB- on silicon_dioxide as an example .
24145018	1	glutamate	147,156	GDH	172,175	glutamate	GDH	CHEBI:29987	2746	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	Clostridium_difficile produces an NAD-specific glutamate dehydrogenase -LRB- GDH -RRB- , which converts l-glutamate into a-ketoglutarate through an irreversible reaction .
3523273	0	glutamate	32,41	GDH	57,60	glutamate	GDH	CHEBI:29987	281785(Tax:9913)	Chemical	Gene	dehydrogenase|amod|START_ENTITY localization|nmod|dehydrogenase localization|appos|END_ENTITY	The subcellular localization of glutamate dehydrogenase -LRB- GDH -RRB- : is GDH a marker for mitochondria in brain ?
3523273	0	glutamate	32,41	GDH	66,69	glutamate	GDH	CHEBI:29987	281785(Tax:9913)	Chemical	Gene	dehydrogenase|amod|START_ENTITY localization|nmod|dehydrogenase localization|parataxis|marker marker|nsubj|END_ENTITY	The subcellular localization of glutamate dehydrogenase -LRB- GDH -RRB- : is GDH a marker for mitochondria in brain ?
11568639	0	glutamate	60,69	GDNF	20,24	glutamate	GDNF	CHEBI:29987	2668	Chemical	Gene	injury|amod|START_ENTITY protects|nmod|injury protects|nsubj|END_ENTITY	Adenovirus-mediated GDNF protects cultured motoneurons from glutamate injury .
12742082	0	glutamate	125,134	GDNF	0,4	glutamate	GDNF	CHEBI:29987	25453(Tax:10116)	Chemical	Gene	up-regulation|amod|START_ENTITY effect|nmod|up-regulation loss|dep|effect aggravates|dobj|loss aggravates|nsubj|pre-treatment pre-treatment|compound|END_ENTITY	GDNF pre-treatment aggravates neuronal cell loss in oxygen-glucose deprived hippocampal slice cultures : a possible effect of glutamate transporter up-regulation .
16163265	0	glutamate	98,107	GDNF	5,9	glutamate	GDNF	CHEBI:29987	14573(Tax:10090)	Chemical	Gene	GLAST|amod|START_ENTITY exert|nmod|GLAST exert|nsubj|END_ENTITY	Does GDNF exert its neuroprotective effects on photoreceptors in the rd1 retina through the glial glutamate transporter GLAST ?
25434487	0	glutamate	33,42	GDNF	62,66	glutamate	GDNF	CHEBI:29987	14573(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY Activation|nmod|receptors enhances|nsubj|Activation enhances|dobj|formation formation|amod|END_ENTITY	Activation of mGlu3 metabotropic glutamate receptors enhances GDNF and GLT-1 formation in the spinal cord and rescues motor neurons in the SOD-1 mouse model of amyotrophic_lateral_sclerosis .
18419760	7	glutamate	1146,1155	GFAP	1182,1186	glutamate	GFAP	CHEBI:29987	14580(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Neutralizing antibodies against TGF-beta completely prevented glutamate and neuronal-induction of GFAP gene , thus indicating that this event is mediated by TGF-beta1 .
10398883	0	glutamate	42,51	GLAST	133,138	glutamate	GLAST	CHEBI:29987	29483(Tax:10116)	Chemical	Gene	buffering|nmod|START_ENTITY patterns|nmod|buffering Changing|dobj|patterns Changing|nsubj|END_ENTITY	Changing patterns of spatial buffering of glutamate in developing rat retinae are mediated by the M ller cell glutamate transporter GLAST .
10515259	0	glutamate	29,38	GLAST	51,56	glutamate	GLAST	CHEBI:29987	6507	Chemical	Gene	transporter|amod|START_ENTITY expression|nmod|transporter END_ENTITY|nsubj|expression	Down-regulated expression of glutamate transporter GLAST in Purkinje cell-associated astrocytes of reeler and weaver_mutant_cerebella .
10523408	0	glutamate	55,64	GLAST	49,54	glutamate	GLAST	CHEBI:29987	6507	Chemical	Gene	transporters|compound|START_ENTITY transporters|amod|END_ENTITY	C-terminal interactions modulate the affinity of GLAST glutamate transporters in salamander retinal glial cells .
10686586	0	glutamate	34,43	GLAST	57,62	glutamate	GLAST	CHEBI:29987	6507	Chemical	Gene	expression|nmod|START_ENTITY transporters|nsubj|expression transporters|dobj|END_ENTITY	Transient expression of the glial glutamate transporters GLAST and GLT in hippocampal neurons in primary culture .
10719077	0	glutamate	14,23	GLAST	38,43	glutamate	GLAST	CHEBI:29987	29483(Tax:10116)	Chemical	Gene	transporters|amod|START_ENTITY Modulation|nmod|transporters Modulation|appos|END_ENTITY	Modulation of glutamate transporters -LRB- GLAST , GLT-1 and EAAC1 -RRB- in the rat cerebellum following portocaval_anastomosis .
10719077	2	glutamate	305,314	GLAST	461,466	glutamate	EAAC1	CHEBI:29987	25550(Tax:10116)	Chemical	Gene	START_ENTITY|parataxis|used used|advcl|analyze analyze|dobj|expression expression|nmod|transporters transporters|appos|END_ENTITY	Extracellular glutamate increases in portocaval_anastomosis -LRB- PCA -RRB- , so we used a portacaval anastomosis model in rats to analyze the expression of glutamate transporters -LRB- GLAST , GLT-1 and EAAC1 -RRB- in rat cerebellum , 1 and 6 months after PCA , using immunohistochemical methods .
10719077	2	glutamate	437,446	GLAST	461,466	glutamate	EAAC1	CHEBI:29987	25550(Tax:10116)	Chemical	Gene	transporters|amod|START_ENTITY transporters|appos|END_ENTITY	Extracellular glutamate increases in portocaval_anastomosis -LRB- PCA -RRB- , so we used a portacaval anastomosis model in rats to analyze the expression of glutamate transporters -LRB- GLAST , GLT-1 and EAAC1 -RRB- in rat cerebellum , 1 and 6 months after PCA , using immunohistochemical methods .
10813794	0	glutamate	20,29	GLAST	43,48	glutamate	GLAST	CHEBI:29987	29483(Tax:10116)	Chemical	Gene	Distribution|nmod|START_ENTITY transporters|nsubj|Distribution transporters|dobj|END_ENTITY	Distribution of the glutamate transporters GLAST and GLT-1 in rat circumventricular organs , meninges , and dorsal root ganglia .
10936189	0	glutamate	20,29	GLAST	14,19	glutamate	GLAST	CHEBI:29987	29483(Tax:10116)	Chemical	Gene	transporters|compound|START_ENTITY transporters|amod|END_ENTITY	The GLT-1 and GLAST glutamate transporters are expressed on morphologically distinct astrocytes and regulated by neuronal activity in primary hippocampal cocultures .
11102482	0	glutamate	63,72	GLAST	85,90	glutamate	GLAST	CHEBI:29987	20512(Tax:10090)	Chemical	Gene	transporter|amod|START_ENTITY lacking|dobj|transporter mice|acl|lacking hearing_loss|nmod|mice Exacerbation|nmod|hearing_loss END_ENTITY|nsubj|Exacerbation	Exacerbation of noise-induced hearing_loss in mice lacking the glutamate transporter GLAST .
11483236	0	glutamate	42,51	GLAST	66,71	glutamate	GLAST	CHEBI:29987	29483(Tax:10116)	Chemical	Gene	transporters|amod|START_ENTITY patterns|nmod|transporters patterns|appos|END_ENTITY	Differential expression patterns of three glutamate transporters -LRB- GLAST , GLT1 and EAAC1 -RRB- in the rat main olfactory bulb .
11707523	0	glutamate	36,45	GLAST	58,63	glutamate	GLAST	CHEBI:29987	29483(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY upregulation|nmod|transporter END_ENTITY|nsubj|upregulation	Transient upregulation of the glial glutamate transporter GLAST in response to fibroblast growth factor , insulin-like growth factor and epidermal_growth_factor in cultured astrocytes .
12225864	0	glutamate	14,23	GLAST	75,80	glutamate	GLAST	CHEBI:29987	20512(Tax:10090)	Chemical	Gene	transporters|amod|START_ENTITY Expression|nmod|transporters Expression|nmod|mice mice|amod|END_ENTITY	Expression of glutamate transporters and ionotropic glutamate receptors in GLAST knockout mice .
12428731	0	glutamate	44,53	GLAST	67,72	glutamate	GLAST	CHEBI:29987	29483(Tax:10116)	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Manganese causes differential regulation of glutamate transporter -LRB- GLAST -RRB- taurine_transporter and metallothionein in cultured rat astrocytes .
12838509	0	glutamate	59,68	GLAST	53,58	glutamate	GLAST	CHEBI:29987	6507	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	Thiamine_deficiency results in downregulation of the GLAST glutamate transporter in cultured astrocytes .
14521256	0	glutamate	14,23	GLAST	36,41	glutamate	GLAST	CHEBI:29987	20512(Tax:10090)	Chemical	Gene	transporter|amod|START_ENTITY Expression|nmod|transporter END_ENTITY|nsubj|Expression	Expression of glutamate transporter GLAST in the developing mouse cochlea .
14723703	0	glutamate	58,67	GLAST	49,54	glutamate	GLAST	CHEBI:29987	6507	Chemical	Gene	transporter|amod|START_ENTITY END_ENTITY|appos|transporter	Mammalian septin Sept2 modulates the activity of GLAST , a glutamate transporter in astrocytes .
15337311	0	glutamate	60,69	GLAST	46,51	glutamate	GLAST	CHEBI:29987	29483(Tax:10116)	Chemical	Gene	transporters|compound|START_ENTITY transporters|compound|END_ENTITY	Astrocytes repress the neuronal expression of GLAST and GLT glutamate transporters in cultured hippocampal neurons from embryonic rats .
15656373	0	glutamate	59,68	GLAST	81,86	glutamate	GLAST	CHEBI:29987	20512(Tax:10090)	Chemical	Gene	-RSB-|amod|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- The culture of retinal muller cells and expression of its glutamate transporter GLAST -RSB- .
16123171	0	glutamate	37,46	GLAST	129,134	glutamate	GLAST	CHEBI:29987	29483(Tax:10116)	Chemical	Gene	uptake|amod|START_ENTITY inhibit|dobj|uptake inhibit|nmod|expression expression|nmod|END_ENTITY	Autoantigen specific T cells inhibit glutamate uptake in astrocytes by decreasing expression of astrocytic glutamate transporter GLAST : a mechanism mediated by tumor_necrosis_factor-alpha .
16524645	0	glutamate	53,62	GLAST	76,81	glutamate	GLAST	CHEBI:29987	6507	Chemical	Gene	expression|nmod|START_ENTITY topiramate|nmod|expression Effect|nmod|topiramate transporters|nsubj|Effect transporters|dobj|END_ENTITY	Effect of topiramate and dBcAMP on expression of the glutamate transporters GLAST and GLT-1 in astrocytes cultured separately , or together with neurons .
16855093	0	glutamate	51,60	GLAST	36,41	glutamate	GLAST	CHEBI:29987	6507	Chemical	Gene	uptake|amod|START_ENTITY mediates|dobj|uptake mediates|nsubj|END_ENTITY	The glutamate-aspartate transporter GLAST mediates glutamate uptake at inner hair cell afferent synapses in the mammalian cochlea .
16880397	0	glutamate	40,49	GLAST	63,68	glutamate	GLAST	CHEBI:29987	20512(Tax:10090)	Chemical	Gene	Indispensability|nmod|START_ENTITY transporters|nsubj|Indispensability transporters|dobj|END_ENTITY	From the Cover : Indispensability of the glutamate transporters GLAST and GLT1 to brain development .
16959378	0	glutamate	71,80	GLAST	46,51	glutamate	GLAST	CHEBI:29987	29483(Tax:10116)	Chemical	Gene	regulation|amod|START_ENTITY decreased|dobj|regulation decreased|nsubj|expression expression|nmod|mediates mediates|amod|END_ENTITY	Reduced plasma membrane surface expression of GLAST mediates decreased glutamate regulation in the aged striatum .
17008380	0	glutamate	37,46	GLAST	31,36	glutamate	GLAST	CHEBI:29987	6507	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	The ionic stoichiometry of the GLAST glutamate transporter in salamander retinal glia .
17226020	6	glutamate	715,724	GLAST	739,744	glutamate	GluR4	CHEBI:29987	14802(Tax:10090)	Chemical	Gene	transporters|amod|START_ENTITY transporters|appos|END_ENTITY	Western blotting and immunohistochemistry were performed using specific antibodies against the glutamate transporters -LRB- GLAST , GLT-1v , EAAC-1 -RRB- and glutamate receptors , particularly NMDA -LRB- NR1 , NR2A , NR2B -RRB- and AMPA -LRB- GluR1 , GluR2/3 , GluR4 -RRB- receptors .
17289278	0	glutamate	32,41	GLAST	55,60	glutamate	GLAST	CHEBI:29987	20512(Tax:10090)	Chemical	Gene	localization|nmod|START_ENTITY transporters|nsubj|localization transporters|dobj|END_ENTITY	Subcellular localization of the glutamate transporters GLAST and GLT at the neuromuscular junction in rodents .
17471058	0	glutamate	69,78	GLAST	91,96	glutamate	GLAST	CHEBI:29987	6507	Chemical	Gene	transporter|amod|START_ENTITY form|nmod|transporter expression|nmod|form END_ENTITY|nsubj|expression	Central nervous system expression of the exon 9 skipping form of the glutamate transporter GLAST .
17513050	2	glutamate	305,314	GLAST	329,334	glutamate	GLAST	CHEBI:29987	20512(Tax:10090)	Chemical	Gene	transporters|compound|START_ENTITY transporters|amod|END_ENTITY	In the cerebellum , glial glutamate transporters , GLAST and GLT-1 , are co-localized in the processes of Bergmann glia wrapping excitatory synapses on Purkinje cells -LRB- PCs -RRB- .
18844020	0	glutamate	10,19	GLAST	88,93	glutamate	GLAST	CHEBI:29987	20512(Tax:10090)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|nmod|END_ENTITY	-LSB- Study on glutamate substrate-induced regulation on expression of glutamate transporter GLAST of mouse retinal M ller cells -RSB- .
19440835	0	glutamate	16,25	GLAST	38,43	glutamate	GLAST	CHEBI:29987	6507	Chemical	Gene	transporter|amod|START_ENTITY Distribution|nmod|transporter END_ENTITY|nsubj|Distribution	Distribution of glutamate transporter GLAST in membranes of cultured astrocytes in the presence of glutamate transport substrates and ATP .
19440835	0	glutamate	99,108	GLAST	38,43	glutamate	GLAST	CHEBI:29987	6507	Chemical	Gene	substrates|amod|START_ENTITY presence|nmod|substrates END_ENTITY|nmod|presence	Distribution of glutamate transporter GLAST in membranes of cultured astrocytes in the presence of glutamate transport substrates and ATP .
19495968	0	glutamate	112,121	GLAST	134,139	glutamate	GLAST	CHEBI:29987	6507	Chemical	Gene	transporter|amod|START_ENTITY redistribution|nmod|transporter END_ENTITY|nsubj|redistribution	Rottlerin inhibits -LRB- Na + , K + -RRB- - ATPase activity in brain tissue and alters D-aspartate dependent redistribution of glutamate transporter GLAST in cultured astrocytes .
19551376	0	glutamate	31,40	GLAST	55,60	glutamate	GLAST	CHEBI:29987	29483(Tax:10116)	Chemical	Gene	transporters|amod|START_ENTITY transporters|appos|END_ENTITY	Differential expression of two glutamate transporters , GLAST and GLT-1 , in an experimental rat model of glaucoma .
22306776	0	glutamate	89,98	GLAST	27,32	glutamate	GLAST	CHEBI:29987	29483(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY supports|dobj|metabolism complex|acl:relcl|supports participates|nmod|complex participates|nsubj|glutamate_transporter glutamate_transporter|appos|END_ENTITY	The glutamate_transporter , GLAST , participates in a macromolecular complex that supports glutamate metabolism .
23070469	0	glutamate	12,21	GLAST	65,70	glutamate	GLAST	CHEBI:29987	29483(Tax:10116)	Chemical	Gene	level|compound|START_ENTITY level|appos|END_ENTITY	Hippocampal glutamate level and glutamate_aspartate transporter -LRB- GLAST -RRB- are up-regulated in senior rat associated with isoflurane-induced spatial_learning / memory_impairment .
23200831	0	glutamate	72,81	GLAST	94,99	glutamate	GLAST	CHEBI:29987	6507	Chemical	Gene	transporter|amod|START_ENTITY expression|nmod|transporter roles|nmod|expression END_ENTITY|nsubj|roles	Modulatory roles of NHERF1 and NHERF2 in cell surface expression of the glutamate transporter GLAST .
9375696	0	glutamate	86,95	GLAST	80,85	glutamate	GLAST	CHEBI:29987	6507	Chemical	Gene	transporters|compound|START_ENTITY transporters|compound|END_ENTITY	Neuronal soluble factors differentially regulate the expression of the GLT1 and GLAST glutamate transporters in cultured astroglia .
9539795	0	glutamate	21,30	GLAST	44,49	glutamate	GLAST	CHEBI:29987	20512(Tax:10090)	Chemical	Gene	Functions|nmod|START_ENTITY transporters|nsubj|Functions transporters|dobj|END_ENTITY	Functions of the two glutamate transporters GLAST and GLT-1 in the retina .
9605214	0	glutamate	22,31	GLAST	44,49	glutamate	GLAST	CHEBI:29987	29483(Tax:10116)	Chemical	Gene	transporter|amod|START_ENTITY expression|nmod|transporter END_ENTITY|nsubj|expression	Altered expression of glutamate transporter GLAST mRNA in rat brain after photochemically induced focal ischemia .
9630235	0	glutamate	18,27	GLAST	42,47	glutamate	GLAST	CHEBI:29987	6507	Chemical	Gene	transporters|amod|START_ENTITY transporters|appos|END_ENTITY	Expression of two glutamate transporters , GLAST and EAAT4 , in the human cerebellum : their correlation in development and neonatal hypoxic-ischemic_damage .
9972824	0	glutamate	49,58	GLAST	72,77	glutamate	GLAST	CHEBI:29987	6507	Chemical	Gene	levels|nmod|START_ENTITY differences|nmod|levels transporters|nsubj|differences transporters|dobj|END_ENTITY	Interindividual differences in the levels of the glutamate transporters GLAST and GLT , but no clear correlation with Alzheimer 's _ disease .
12123612	0	glutamate	52,61	GLR-1	46,51	glutamate	GLR-1	CHEBI:29987	176204(Tax:6239)	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Ubiquitin and AP180 regulate the abundance of GLR-1 glutamate receptors at postsynaptic elements in C. _ elegans .
14573539	0	glutamate	18,27	GLR-1	0,5	glutamate	GLR-1	CHEBI:29987	176204(Tax:6239)	Chemical	Gene	homolog|amod|START_ENTITY END_ENTITY|appos|homolog	GLR-1 , a non-NMDA glutamate receptor homolog , is critical for long-term memory in Caenorhabditis_elegans .
14749834	0	glutamate	49,58	GLR-1	43,48	glutamate	GLR-1	CHEBI:29987	176204(Tax:6239)	Chemical	Gene	function|compound|START_ENTITY function|compound|END_ENTITY	SOL-1 is a CUB-domain protein required for GLR-1 glutamate receptor function in C. _ elegans .
14981253	0	glutamate	79,88	GLR-1	73,78	glutamate	GLR-1	CHEBI:29987	176204(Tax:6239)	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Clathrin-mediated endocytosis is required for compensatory regulation of GLR-1 glutamate receptors after activity blockade .
15556870	0	glutamate	64,73	GLR-1	58,63	glutamate	GLR-1	CHEBI:29987	176204(Tax:6239)	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	The anaphase-promoting_complex regulates the abundance of GLR-1 glutamate receptors in the ventral nerve cord of C. _ elegans .
15820693	0	glutamate	77,86	GLR-1	71,76	glutamate	GLR-1	CHEBI:29987	176204(Tax:6239)	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	LIN-23-mediated degradation of beta-catenin regulates the abundance of GLR-1 glutamate receptors in the ventral nerve cord of C. _ elegans .
16418277	0	glutamate	65,74	GLR-1	59,64	glutamate	GLR-1	CHEBI:29987	176204(Tax:6239)	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	SOL-1 is an auxiliary subunit that modulates the gating of GLR-1 glutamate receptors in Caenorhabditis_elegans .
17671168	0	glutamate	39,48	GLR-1	33,38	glutamate	GLR-1	CHEBI:29987	176204(Tax:6239)	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	CDK-5 regulates the abundance of GLR-1 glutamate receptors in the ventral cord of Caenorhabditis_elegans .
22855524	0	glutamate	76,85	GLR-1	70,75	glutamate	GLR-1	CHEBI:29987	176204(Tax:6239)	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	The kinesin-3 family motor KLP-4 regulates anterograde trafficking of GLR-1 glutamate receptors in the ventral nerve cord of Caenorhabditis_elegans .
7477293	0	glutamate	62,71	GLR-1	56,61	glutamate	GLR-1	CHEBI:29987	176204(Tax:6239)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Mechanosensory signalling in C. _ elegans mediated by the GLR-1 glutamate receptor .
7477294	0	glutamate	66,75	GLR-1	60,65	glutamate	GLR-1	CHEBI:29987	176204(Tax:6239)	Chemical	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Synaptic code for sensory modalities revealed by C. _ elegans GLR-1 glutamate receptor .
10098717	0	glutamate	31,40	GLT-1	70,75	glutamate	GLT-1	CHEBI:29987	6506	Chemical	Gene	transporters|compound|START_ENTITY family|nmod|transporters family|dep|focus focus|nmod|subtype subtype|compound|END_ENTITY	The family of sodium-dependent glutamate transporters : a focus on the GLT-1 / EAAT2 subtype .
10336558	0	glutamate	49,58	GLT-1	18,23	glutamate	GLT-1	CHEBI:29987	6506	Chemical	Gene	transporter|amod|START_ENTITY subtype|dep|transporter subtype|compound|END_ENTITY	Expression of the GLT-1 subtype of Na + - dependent glutamate transporter : pharmacological characterization and lack of regulation by protein_kinase_C .
10719077	0	glutamate	14,23	GLT-1	45,50	glutamate	GLT-1	CHEBI:29987	29482(Tax:10116)	Chemical	Gene	transporters|amod|START_ENTITY Modulation|nmod|transporters Modulation|appos|GLAST GLAST|dep|END_ENTITY	Modulation of glutamate transporters -LRB- GLAST , GLT-1 and EAAC1 -RRB- in the rat cerebellum following portocaval_anastomosis .
10739305	0	glutamate	33,42	GLT-1	64,69	glutamate	GLT-1	CHEBI:29987	29482(Tax:10116)	Chemical	Gene	proteins|amod|START_ENTITY study|nmod|proteins END_ENTITY|nsubj|study	Immunohistochemical study of the glutamate transporter proteins GLT-1 and GLAST in rat and gerbil pineal gland .
10762090	0	glutamate	6,15	GLT-1	28,33	glutamate	GLT-1	CHEBI:29987	6506	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|down-regulation down-regulation|amod|END_ENTITY	Glial glutamate transporter GLT-1 down-regulation precedes delayed neuronal_death in gerbil hippocampus following transient global_cerebral_ischemia .
10961660	0	glutamate	40,49	GLT-1	68,73	glutamate	GLT-1	CHEBI:29987	29482(Tax:10116)	Chemical	Gene	levels|nmod|START_ENTITY transport|nsubj|levels transport|dobj|END_ENTITY	Decreased cortical levels of astrocytic glutamate transport protein GLT-1 in a rat model of posttraumatic_epilepsy .
11283952	0	glutamate	33,42	GLT-1	56,61	glutamate	GLT-1	CHEBI:29987	29482(Tax:10116)	Chemical	Gene	distribution|nmod|START_ENTITY transporters|nsubj|distribution transporters|dobj|END_ENTITY	Differential distribution of the glutamate transporters GLT-1 and GLAST in tanycytes of the third ventricle .
11461977	0	glutamate	10,19	GLT-1	33,38	glutamate	GLT-1	CHEBI:29987	6506	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	The glial glutamate transporter , GLT-1 , is oxidatively modified by 4-hydroxy-2-nonenal in the Alzheimer 's _ disease brain : the role of Abeta1-42 .
11483659	0	glutamate	43,52	GLT-1	66,71	glutamate	GLT-1	CHEBI:29987	29482(Tax:10116)	Chemical	Gene	down-regulation|nmod|START_ENTITY transporters|nsubj|down-regulation transporters|dobj|END_ENTITY	Selective down-regulation of the astrocyte glutamate transporters GLT-1 and GLAST within the medial thalamus in experimental Wernicke 's _ encephalopathy .
11849297	0	glutamate	59,68	GLT-1	45,50	glutamate	GLT-1	CHEBI:29987	20511(Tax:10090)	Chemical	Gene	uptake|amod|START_ENTITY reduces|dobj|uptake reduces|csubj|Knocking Knocking|dobj|END_ENTITY	Knocking out the glial glutamate transporter GLT-1 reduces glutamate uptake but does not affect hippocampal glutamate dynamics in early simulated ischaemia .
12324450	0	glutamate	86,95	GLT-1	69,74	glutamate	GLT-1	CHEBI:29987	6506	Chemical	Gene	transporter|amod|START_ENTITY subtype|nmod|transporter subtype|compound|END_ENTITY	Protein kinase C activation decreases cell surface expression of the GLT-1 subtype of glutamate transporter .
12451116	0	glutamate	52,61	GLT-1	72,77	glutamate	GLT-1	CHEBI:29987	6506	Chemical	Gene	currents|nmod|START_ENTITY Comparison|nmod|currents uptake|nsubj|Comparison uptake|nmod|transporters transporters|compound|END_ENTITY	Comparison of coupled and uncoupled currents during glutamate uptake by GLT-1 transporters .
12723093	0	glutamate	55,64	GLT-1	35,40	glutamate	GLT-1	CHEBI:29987	443495(Tax:9940)	Chemical	Gene	transporters|amod|START_ENTITY transporters|compound|END_ENTITY	Content of ileal EAAC1 and hepatic GLT-1 high-affinity glutamate transporters is increased in growing vs. nongrowing lambs , paralleling increased tissue D - _ and_L-glutamate , plasma glutamine , and alanine concentrations .
14690536	0	glutamate	95,104	GLT-1	117,122	glutamate	GLT-1	CHEBI:29987	20511(Tax:10090)	Chemical	Gene	transporter|amod|START_ENTITY down-regulates|dobj|transporter down-regulates|xcomp|END_ENTITY	Expression of SOD1 G93A or wild-type SOD1 in primary cultures of astrocytes down-regulates the glutamate transporter GLT-1 : lack of involvement of oxidative stress .
14750980	0	glutamate	36,45	GLT-1	27,32	glutamate	GLT-1	CHEBI:29987	29482(Tax:10116)	Chemical	Gene	transporter|amod|START_ENTITY END_ENTITY|appos|transporter	Effect of gene transfer of GLT-1 , a glutamate transporter , into the locus coeruleus by recombinant adenoviruses on morphine physical dependence in rats .
15175388	0	glutamate	113,122	GLT-1	96,101	glutamate	GLT-1	CHEBI:29987	6506	Chemical	Gene	transporter|amod|START_ENTITY subtype|nmod|transporter subtype|compound|END_ENTITY	Identification of motifs involved in endoplasmic reticulum retention-forward trafficking of the GLT-1 subtype of glutamate transporter .
15466883	0	glutamate	57,66	GLT-1	45,50	glutamate	GLT-1	CHEBI:29987	403750(Tax:9615)	Chemical	Gene	transporter|amod|START_ENTITY glial|dobj|transporter glial|nsubj|internalisation internalisation|nmod|END_ENTITY	Increased internalisation and degradation of GLT-1 glial glutamate transporter in a cell model for familial amyotrophic_lateral_sclerosis -LRB- ALS -RRB- .
16026460	0	glutamate	54,63	GLT-1	12,17	glutamate	GLT-1	CHEBI:29987	29482(Tax:10116)	Chemical	Gene	homeostasis|amod|START_ENTITY glutamate_transporter|nmod|homeostasis subtype|nmod|glutamate_transporter subtype|compound|END_ENTITY	Role of the GLT-1 subtype of glutamate_transporter in glutamate homeostasis : the GLT-1-preferring inhibitor WAY-855 produces marginal neurotoxicity in the rat hippocampus .
16324108	0	glutamate	26,35	GLT-1	17,22	glutamate	GLT-1	CHEBI:29987	29482(Tax:10116)	Chemical	Gene	transporter|amod|START_ENTITY END_ENTITY|appos|transporter	Gene transfer of GLT-1 , a glutamate transporter , into the nucleus accumbens shell attenuates methamphetamine - and morphine-induced conditioned place preference in rats .
16530295	0	glutamate	65,74	GLT-1	146,151	glutamate	GLT-1	CHEBI:29987	20511(Tax:10090)	Chemical	Gene	transporters|amod|START_ENTITY Effects|nmod|transporters Effects|dep|Evidence Evidence|nmod|up-regulation up-regulation|nmod|END_ENTITY	Effects of lipopolysaccharide on glial phenotype and activity of glutamate transporters : Evidence for delayed up-regulation and redistribution of GLT-1 .
16573655	0	glutamate	25,34	GLT-1	121,126	glutamate	GLT-1	CHEBI:29987	6506	Chemical	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|dep|evidence evidence|nmod|effect effect|nmod|subtype subtype|compound|END_ENTITY	Regulation of astrocytic glutamate transporter expression by Akt : evidence for a selective transcriptional effect on the GLT-1 / EAAT2 subtype .
16819765	7	glutamate	1259,1268	GLT-1	1483,1488	glutamate	MCP-1	CHEBI:29987	6347	Chemical	Gene	transporters|amod|START_ENTITY increase|nmod|transporters found|nsubjpass|increase found|xcomp|have have|xcomp|suggesting suggesting|ccomp|END_ENTITY	Importantly , the observed increase in glutamate transporters was found to have a functional effect , with significantly enhanced glutamate uptake in astrocytes treated with 100 or 1,000 microM PPF that was sensitive to dihydrokainate inhibition , suggesting it is GLT-1 mediated .
16819765	7	glutamate	1349,1358	GLT-1	1483,1488	glutamate	MCP-1	CHEBI:29987	6347	Chemical	Gene	uptake|amod|START_ENTITY effect|nmod|uptake have|dobj|effect have|xcomp|suggesting suggesting|ccomp|END_ENTITY	Importantly , the observed increase in glutamate transporters was found to have a functional effect , with significantly enhanced glutamate uptake in astrocytes treated with 100 or 1,000 microM PPF that was sensitive to dihydrokainate inhibition , suggesting it is GLT-1 mediated .
17028421	0	glutamate	35,44	GLT-1	29,34	glutamate	GLT-1	CHEBI:29987	29482(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|END_ENTITY	Glucocorticoid regulation of GLT-1 glutamate transporter isoform expression in the rat hippocampus .
17513050	0	glutamate	80,89	GLT-1	38,43	glutamate	GLT-1	CHEBI:29987	20511(Tax:10090)	Chemical	Gene	released|dobj|START_ENTITY released|nsubj|Contribution Contribution|nmod|END_ENTITY	Contribution of glutamate transporter GLT-1 to removal of synaptically released glutamate at climbing fiber-Purkinje cell synapses .
18658151	0	glutamate	119,128	GLT-1	141,146	glutamate	GLT-1	CHEBI:29987	6506	Chemical	Gene	EAAT2|compound|START_ENTITY EAAT2|compound|END_ENTITY	Substrates and non-transportable analogues induce structural rearrangements at the extracellular entrance of the glial glutamate transporter GLT-1 / EAAT2 .
18805448	0	glutamate	74,83	GLT-1	97,102	glutamate	GLT-1	CHEBI:29987	6506	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Ubiquitination-mediated internalization and degradation of the astroglial glutamate transporter , GLT-1 .
19323820	0	glutamate	32,41	GLT-1	55,60	glutamate	GLT-1	CHEBI:29987	29482(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY transporters|nmod|expression transporters|dobj|END_ENTITY	Plasticity in expression of the glutamate transporters GLT-1 and GLAST in spinal dorsal horn glial cells following partial sciatic nerve ligation .
22285253	0	glutamate	62,71	GLT-1	19,24	glutamate	GLT-1	CHEBI:29987	6506	Chemical	Gene	reuptake|amod|START_ENTITY expression|amod|reuptake increases|dobj|expression increases|nsubj|blockade blockade|compound|END_ENTITY	Transient striatal GLT-1 blockade increases EAAC1 expression , glutamate reuptake , and decreases tyrosine hydroxylase phosphorylation at ser -LRB- 19 -RRB- .
22627295	0	glutamate	60,69	GLT-1	54,59	glutamate	GLT-1	CHEBI:29987	29482(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Aroclor_1254 selectively inhibits expression of glial GLT-1 glutamate transporter in the forebrain of chronically exposed adult rat .
22645130	0	glutamate	16,25	GLT-1	38,43	glutamate	GLT-1	CHEBI:29987	29482(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	GPR30 regulates glutamate transporter GLT-1 expression in rat primary astrocytes .
22711563	0	glutamate	24,33	GLT-1	46,51	glutamate	GLT-1	CHEBI:29987	29482(Tax:10116)	Chemical	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	Trichostatin_A enhances glutamate transporter GLT-1 mRNA levels in C6_glioma cells via neurosteroid-mediated cell differentiation .
22998524	0	glutamate	27,36	GLT-1	13,18	glutamate	GLT-1	CHEBI:29987	29482(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|resists resists|compound|END_ENTITY	Up-regulated GLT-1 resists glutamate toxicity and attenuates glutamate-induced calcium loading in cultured neurocytes .
23166293	0	glutamate	50,59	GLT-1	44,49	glutamate	GLT-1	CHEBI:29987	6506	Chemical	Gene	START_ENTITY|nsubj|Relationship Relationship|nmod|increase increase|nmod|END_ENTITY	Relationship between increase in astrocytic GLT-1 glutamate transport and late-LTP .
23516295	0	glutamate	55,64	GLT-1	93,98	glutamate	GLT-1	CHEBI:29987	20511(Tax:10090)	Chemical	Gene	clearance|nmod|START_ENTITY slows|dobj|clearance slows|advcl|mislocalizing mislocalizing|dobj|END_ENTITY	Amyloid-b1-42 slows clearance of synaptically released glutamate by mislocalizing astrocytic GLT-1 .
23936321	0	glutamate	23,32	GLT-1	84,89	glutamate	GLT-1	CHEBI:29987	29482(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|uptake uptake|nmod|END_ENTITY	Impairment of neuronal glutamate uptake and modulation of the glutamate transporter GLT-1 induced by retinal_ischemia .
23988842	0	glutamate	102,111	GLT-1	125,130	glutamate	GLT-1	CHEBI:29987	6506	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	The effects of astrocytes on differentiation of neural stem cells are influenced by knock-down of the glutamate transporter , GLT-1 .
24224925	0	glutamate	65,74	GLT-1	4,9	glutamate	GLT-1	CHEBI:29987	20511(Tax:10090)	Chemical	Gene	homeostasis|amod|START_ENTITY essential|nmod|homeostasis glutamate|ccomp|essential glutamate|nsubj|END_ENTITY	The GLT-1 -LRB- EAAT2 ; slc1a2 -RRB- glutamate transporter is essential for glutamate homeostasis in the neocortex of the mouse .
24246642	0	glutamate	24,33	GLT-1	9,14	glutamate	GLT-1	CHEBI:29987	29482(Tax:10116)	Chemical	Gene	uptake|amod|START_ENTITY mediated|dobj|uptake mediated|nsubj|END_ENTITY	Enhanced GLT-1 mediated glutamate uptake and migration of primary astrocytes directed by fibronectin-coated electrospun poly-L-lactic_acid fibers .
24376419	0	glutamate	24,33	GLT-1	89,94	glutamate	GLT-1	CHEBI:29987	29482(Tax:10116)	Chemical	Gene	clearance|amod|START_ENTITY promotes|dobj|clearance promotes|nmod|END_ENTITY	Ginsenoside_Rd promotes glutamate clearance by up-regulating glial glutamate transporter GLT-1 via PI3K/AKT and ERK1/2 pathways .
24643365	0	glutamate	42,51	GLT-1	107,112	glutamate	GLT-1	CHEBI:29987	29482(Tax:10116)	Chemical	Gene	excitotoxicity|amod|START_ENTITY reduces|dobj|excitotoxicity reduces|advcl|up-regulating up-regulating|dobj|activity activity|nmod|END_ENTITY	Cerebral ischemic preconditioning reduces glutamate excitotoxicity by up-regulating the uptake activity of GLT-1 in rats .
25454285	0	glutamate	31,40	GLT-1	54,59	glutamate	GLT-1	CHEBI:29987	29482(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY transporters|nsubj|regulation transporters|dobj|END_ENTITY	Differential regulation of the glutamate transporters GLT-1 and GLAST by GSK3b .
25806702	0	glutamate	16,25	GLT-1	61,66	glutamate	GLT-1	D018698	29482(Tax:10116)	Chemical	Gene	fluctuations|compound|START_ENTITY Imaging|nmod|fluctuations Imaging|dep|challenge challenge|compound|END_ENTITY	Imaging in vivo glutamate fluctuations with -LSB- -LRB- 11 -RRB- C -RSB- ABP688 : a GLT-1 challenge with ceftriaxone .
25834045	0	glutamate	168,177	GLT-1	133,138	glutamate	GLT-1	D018698	20511(Tax:10090)	Chemical	Gene	contributes|xcomp|START_ENTITY contributes|nsubj|END_ENTITY	Conditional deletion of the glutamate transporter GLT-1 reveals that astrocytic GLT-1 protects against fatal epilepsy while neuronal GLT-1 contributes significantly to glutamate uptake into synaptosomes .
25834045	0	glutamate	168,177	GLT-1	50,55	glutamate	GLT-1	D018698	20511(Tax:10090)	Chemical	Gene	contributes|xcomp|START_ENTITY protects|advcl|contributes reveals|ccomp|protects reveals|nsubj|deletion deletion|nmod|END_ENTITY	Conditional deletion of the glutamate transporter GLT-1 reveals that astrocytic GLT-1 protects against fatal epilepsy while neuronal GLT-1 contributes significantly to glutamate uptake into synaptosomes .
25834045	0	glutamate	168,177	GLT-1	80,85	glutamate	GLT-1	D018698	20511(Tax:10090)	Chemical	Gene	contributes|xcomp|START_ENTITY protects|advcl|contributes protects|nsubj|END_ENTITY	Conditional deletion of the glutamate transporter GLT-1 reveals that astrocytic GLT-1 protects against fatal epilepsy while neuronal GLT-1 contributes significantly to glutamate uptake into synaptosomes .
25834045	0	glutamate	28,37	GLT-1	133,138	glutamate	GLT-1	D018698	20511(Tax:10090)	Chemical	Gene	GLT-1|amod|START_ENTITY deletion|nmod|GLT-1 reveals|nsubj|deletion reveals|ccomp|protects protects|advcl|contributes contributes|nsubj|END_ENTITY	Conditional deletion of the glutamate transporter GLT-1 reveals that astrocytic GLT-1 protects against fatal epilepsy while neuronal GLT-1 contributes significantly to glutamate uptake into synaptosomes .
25834045	0	glutamate	28,37	GLT-1	80,85	glutamate	GLT-1	D018698	20511(Tax:10090)	Chemical	Gene	GLT-1|amod|START_ENTITY deletion|nmod|GLT-1 reveals|nsubj|deletion reveals|ccomp|protects protects|nsubj|END_ENTITY	Conditional deletion of the glutamate transporter GLT-1 reveals that astrocytic GLT-1 protects against fatal epilepsy while neuronal GLT-1 contributes significantly to glutamate uptake into synaptosomes .
26002627	0	glutamate	67,76	GLT-1	116,121	glutamate	GLT-1	D018698	29482(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY ethanol|dobj|concentration ethanol|nmod|normalization normalization|nmod|END_ENTITY	Ceftriaxone attenuates ethanol drinking and restores extracellular glutamate concentration through normalization of GLT-1 in nucleus accumbens of male alcohol-preferring rats .
26543027	0	glutamate	25,34	GLT-1	58,63	glutamate	GLT-1	D018698	20511(Tax:10090)	Chemical	Gene	subtype|amod|START_ENTITY enhances|dobj|subtype Clavulanic_acid|dep|enhances Clavulanic_acid|nsubj|I I|appos|END_ENTITY	Clavulanic_acid enhances glutamate transporter subtype I -LRB- GLT-1 -RRB- expression and decreases reinforcing efficacy of cocaine in mice .
27085607	0	glutamate	39,48	GLT-1	72,77	glutamate	GLT-1	D018698	6506	Chemical	Gene	transporter|amod|START_ENTITY downregulates|dobj|transporter downregulates|dep|subtype subtype|dep|END_ENTITY	Synthetic cathinone MDPV downregulates glutamate transporter subtype I -LRB- GLT-1 -RRB- and produces rewarding and locomotor-activating effects that are reduced by a GLT-1 activator .
27085607	0	glutamate	39,48	GLT-1	72,77	glutamate	GLT-1	D018698	6506	Chemical	Gene	transporter|amod|START_ENTITY downregulates|dobj|transporter downregulates|dep|subtype subtype|dep|END_ENTITY	Synthetic cathinone MDPV downregulates glutamate transporter subtype I -LRB- GLT-1 -RRB- and produces rewarding and locomotor-activating effects that are reduced by a GLT-1 activator .
7615503	0	glutamate	89,98	GLT-1	61,66	glutamate	GLT-1	CHEBI:29987	29482(Tax:10116)	Chemical	Gene	transporter|amod|START_ENTITY coupled|dobj|transporter coupled|nsubj|discrimination discrimination|nmod|END_ENTITY	Glutamate_404 is involved in the substrate discrimination of GLT-1 , a -LRB- Na + + K + -RRB- - coupled glutamate transporter from rat brain .
7913472	0	glutamate	74,83	GLT-1	46,51	glutamate	GLT-1	CHEBI:29987	29482(Tax:10116)	Chemical	Gene	transporter|amod|START_ENTITY coupled|dobj|transporter coupled|nsubj|function function|nmod|END_ENTITY	Histidine 326 is critical for the function of GLT-1 , a -LRB- Na + + K + -RRB- - coupled glutamate transporter from rat brain .
9145792	0	glutamate	20,29	GLT-1	43,48	glutamate	GLT-1	CHEBI:29987	29482(Tax:10116)	Chemical	Gene	Expression|nmod|START_ENTITY transporters|nsubj|Expression transporters|ccomp|unchanged unchanged|nsubj|END_ENTITY	Expression of glial glutamate transporters GLT-1 and GLAST is unchanged in the hippocampus in fully kindled rats .
9326278	0	glutamate	52,61	GLT-1	27,32	glutamate	GLT-1	CHEBI:29987	29482(Tax:10116)	Chemical	Gene	transporter|amod|START_ENTITY expression|dep|transporter expression|nmod|+ +|compound|END_ENTITY	Functional expression of a GLT-1 type Na + - dependent glutamate transporter in rat pinealocytes .
9498811	0	glutamate	103,112	GLT-1	28,33	glutamate	GLT-1	CHEBI:29987	6506	Chemical	Gene	START_ENTITY|nsubj|expression expression|nmod|transporter transporter|amod|glutamate glutamate|amod|END_ENTITY	Inducible expression of the GLT-1 glutamate transporter in a CHO cell line selected for low endogenous glutamate uptake .
9563512	0	glutamate	55,64	GLT-1	46,51	glutamate	GLT-1	CHEBI:29987	29482(Tax:10116)	Chemical	Gene	stimulation|compound|START_ENTITY glutamate|nmod|stimulation glutamate|dobj|END_ENTITY	Regulation of the glial glutamate transporter GLT-1 by glutamate and delta-opioid receptor stimulation .
9592062	0	glutamate	57,66	GLT-1	79,84	glutamate	GLT-1	CHEBI:29987	6506	Chemical	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	Chronic neuroleptic treatment alters expression of glial glutamate transporter GLT-1 mRNA in the striatum .
9600674	0	glutamate	18,27	GLT-1	12,17	glutamate	GLT-1	CHEBI:29987	20511(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Spinal cord GLT-1 glutamate transporter and blood glutamic_acid alterations in motor neuron_degeneration -LRB- Mnd -RRB- mice .
10380073	0	glutamate	12,21	GLT1	0,4	glutamate	GLT1	CHEBI:29987	443495(Tax:9940)	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|appos|transporter	GLT1 , glial glutamate transporter , is transiently expressed in neurons and develops astrocyte specificity only after midgestation in the ovine fetal brain .
10642749	0	glutamate	49,58	GLT1	123,127	glutamate	GLT1	CHEBI:29987	29482(Tax:10116)	Chemical	Gene	alteration|amod|START_ENTITY produced|nmod|alteration produced|nmod|expression expression|compound|END_ENTITY	Characterization of striatal lesions produced by glutamate uptake alteration : cell death , reactive gliosis , and changes in GLT1 and GADD45 mRNA expression .
10812201	0	glutamate	18,27	GLT1	41,45	glutamate	GLT1	CHEBI:29987	6506	Chemical	Gene	transporters|nsubj|START_ENTITY transporters|ccomp|regulated regulated|nsubjpass|END_ENTITY	The high-affinity glutamate transporters GLT1 , GLAST , and EAAT4 are regulated via different signalling mechanisms .
11483236	0	glutamate	42,51	GLT1	73,77	glutamate	GLT1	CHEBI:29987	29482(Tax:10116)	Chemical	Gene	transporters|amod|START_ENTITY patterns|nmod|transporters patterns|appos|GLAST GLAST|dep|END_ENTITY	Differential expression patterns of three glutamate transporters -LRB- GLAST , GLT1 and EAAC1 -RRB- in the rat main olfactory bulb .
11896154	0	glutamate	36,45	GLT1	58,62	glutamate	GLT1	CHEBI:29987	29482(Tax:10116)	Chemical	Gene	transporter|amod|START_ENTITY form|nmod|transporter Expression|nmod|form END_ENTITY|nsubj|Expression	Expression of a variant form of the glutamate transporter GLT1 in neuronal cultures and in neurons and astrocytes in the rat brain .
12805317	0	glutamate	30,39	GLT1	95,99	glutamate	GLT1	CHEBI:29987	29482(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|expression expression|nmod|END_ENTITY	Morphine withdrawal increases glutamate uptake and surface expression of glutamate transporter GLT1 at hippocampal synapses .
12883409	10	glutamate	1791,1800	GLT1	1703,1707	glutamate	GLT1	CHEBI:29987	6506	Chemical	Gene	uptake|amod|START_ENTITY modify|nmod|uptake modify|nsubj|inhibition inhibition|nmod|transporter transporter|compound|END_ENTITY	The inhibition of the glial GLT1 transporter by 3-methyl-glutamate did not further modify the effect of propofol on glutamate uptake , suggesting that GLT1 was not the major target of propofol .
15777760	0	glutamate	31,40	GLT1	54,58	glutamate	GLT1	CHEBI:29987	6506	Chemical	Gene	modulation|nmod|START_ENTITY transporters|nsubj|modulation transporters|dobj|END_ENTITY	Differential modulation of the glutamate transporters GLT1 , GLAST and EAAC1 by docosahexaenoic_acid .
17631920	0	glutamate	135,144	GLT1	120,124	glutamate	GLT1	CHEBI:29987	29482(Tax:10116)	Chemical	Gene	subtypes|amod|START_ENTITY subtypes|compound|END_ENTITY	Prenatal exposure to the cannabinoid receptor agonist WIN_55 ,212 -2 increases glutamate uptake through overexpression of GLT1 and EAAC1 glutamate transporter subtypes in rat frontal cerebral cortex .
17631920	0	glutamate	77,86	GLT1	120,124	glutamate	GLT1	CHEBI:29987	29482(Tax:10116)	Chemical	Gene	uptake|amod|START_ENTITY increases|amod|uptake agonist|dobj|increases agonist|nmod|overexpression overexpression|nmod|subtypes subtypes|compound|END_ENTITY	Prenatal exposure to the cannabinoid receptor agonist WIN_55 ,212 -2 increases glutamate uptake through overexpression of GLT1 and EAAC1 glutamate transporter subtypes in rat frontal cerebral cortex .
18353560	0	glutamate	43,52	GLT1	17,21	glutamate	GLT1	CHEBI:29987	20511(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Up-regulation Up-regulation|nmod|increases increases|compound|END_ENTITY	Up-regulation of GLT1 expression increases glutamate uptake and attenuates the Huntington 's _ disease phenotype in the R6/2 mouse .
18381652	0	glutamate	38,47	GLT1	33,37	glutamate	GLT1	CHEBI:29987	29482(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	PKC-dependent endocytosis of the GLT1 glutamate transporter depends on ubiquitylation of lysines located in a C-terminal cluster .
19014361	0	glutamate	47,56	GLT1	70,74	glutamate	GLT1	CHEBI:29987	29482(Tax:10116)	Chemical	Gene	Expression|nmod|START_ENTITY transporters|nsubj|Expression transporters|dobj|END_ENTITY	Expression and distribution of ` high affinity ' glutamate transporters GLT1 , GLAST , EAAC1 and of GCPII in the rat peripheral nervous system .
19457061	0	glutamate	23,32	GLT1	45,49	glutamate	GLT1	CHEBI:29987	29482(Tax:10116)	Chemical	Gene	form|amod|START_ENTITY form|compound|END_ENTITY	Splice variants of the glutamate transporter GLT1 form hetero-oligomers that interact with PSD-95 and NMDA receptors .
19614985	0	glutamate	61,70	GLT1	48,52	glutamate	GLT1	CHEBI:29987	29482(Tax:10116)	Chemical	Gene	concentrations|compound|START_ENTITY Evidence|nmod|concentrations Evidence|nmod|coupling coupling|nmod|END_ENTITY	Evidence for change in current-flux coupling of GLT1 at high glutamate concentrations in rat primary forebrain neurons and GLT1a-expressing COS-7 cells .
19941959	0	glutamate	107,116	GLT1	92,96	glutamate	GLT1	D018698	29482(Tax:10116)	Chemical	Gene	transporters|compound|START_ENTITY transporters|compound|END_ENTITY	Altered regulation of glutamate release and decreased functional activity and expression of GLT1 and GLAST glutamate transporters in the hippocampus of adolescent rats perinatally exposed to Delta -LRB- 9 -RRB- - THC .
19941959	0	glutamate	22,31	GLT1	92,96	glutamate	GLT1	D018698	29482(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY regulation|nmod|release regulation|nmod|transporters transporters|compound|END_ENTITY	Altered regulation of glutamate release and decreased functional activity and expression of GLT1 and GLAST glutamate transporters in the hippocampus of adolescent rats perinatally exposed to Delta -LRB- 9 -RRB- - THC .
20152807	0	glutamate	45,54	GLT1	74,78	glutamate	GLT1	CHEBI:29987	6506	Chemical	Gene	function|amod|START_ENTITY function|nmod|END_ENTITY	Human adipose-derived stem cells enhance the glutamate uptake function of GLT1 in SOD1 -LRB- G93A -RRB- - bearing astrocytes .
21335552	0	glutamate	10,19	GLT1	35,39	glutamate	GLT1	CHEBI:29987	6506	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	The glial glutamate transporter 1 -LRB- GLT1 -RRB- is expressed by pancreatic beta-cells and prevents glutamate-induced beta-cell death .
21882244	0	glutamate	41,50	GLT1	64,68	glutamate	GLT1	CHEBI:29987	20511(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Reduction in expression of the astrocyte glutamate transporter , GLT1 , worsens functional and histological outcomes following traumatic spinal_cord_injury .
23396537	0	glutamate	76,85	GLT1	98,102	glutamate	GLT1	CHEBI:29987	20511(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|dysregulation dysregulation|compound|END_ENTITY	Astroglial FMRP-dependent translational down-regulation of mGluR5 underlies glutamate transporter GLT1 dysregulation in the fragile_X mouse .
8923741	0	glutamate	94,103	GLT1	16,20	glutamate	GLT1	CHEBI:29987	851383(Tax:4932)	Chemical	Gene	synthase|compound|START_ENTITY structure|nmod|synthase reveals|dobj|structure reveals|nsubj|Sequence Sequence|nmod|gene gene|compound|END_ENTITY	Sequence of the GLT1 gene from Saccharomyces_cerevisiae reveals the domain structure of yeast glutamate synthase .
9108197	0	glutamate	33,42	GLT1	56,60	glutamate	GLT1	CHEBI:29987	29482(Tax:10116)	Chemical	Gene	distribution|nmod|START_ENTITY transporters|nsubj|distribution transporters|dobj|END_ENTITY	Differential distribution of the glutamate transporters GLT1 and rEAAC1 in rat cerebral cortex and thalamus : an in situ hybridization analysis .
10429370	0	glutamate	63,72	GLUD1	88,93	glutamate	GLUD1	CHEBI:29987	2746	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of a novel single base-pair polymorphism in the glutamate dehydrogenase -LRB- GLUD1 -RRB- gene .
11201367	0	glutamate	87,96	GLUD1	112,117	glutamate	GLUD1	CHEBI:29987	2746	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	A Japanese case of congenital_hyperinsulinism with hyperammonemia due to a mutation in glutamate dehydrogenase -LRB- GLUD1 -RRB- gene .
12324473	0	glutamate	87,96	GLUD1	80,85	glutamate	GLUD1	CHEBI:29987	2746	Chemical	Gene	dehydrogenase|amod|START_ENTITY housekeeping|amod|dehydrogenase housekeeping|appos|END_ENTITY	Substitution of Ser_for_Arg-443 in the regulatory domain of human housekeeping -LRB- GLUD1 -RRB- glutamate dehydrogenase virtually abolishes basal activity and markedly alters the activation of the enzyme by ADP and L-leucine .
21446915	0	glutamate	139,148	GLUD1	50,55	glutamate	GLUD1	D018698	14661(Tax:10090)	Chemical	Gene	release|amod|START_ENTITY gene|nmod|release levels|nmod|gene levels|nmod|glutamate_dehydrogenase_1 glutamate_dehydrogenase_1|appos|END_ENTITY	Differential levels of glutamate_dehydrogenase_1 -LRB- GLUD1 -RRB- in Balb/c and C57BL/6 mice and the effects of overexpression of the Glud1 gene on glutamate release in striatum .
26656609	0	glutamate	24,33	GLUD1	49,54	glutamate	GLUD1	D018698	2746	Chemical	Gene	dehydrogenase|amod|START_ENTITY mutation|nmod|dehydrogenase mutation|appos|END_ENTITY	A novel mutation in the glutamate dehydrogenase -LRB- GLUD1 -RRB- of a patient with congenital_hyperinsulinism-hyperammonemia -LRB- HI/HA -RRB- .
8244384	0	glutamate	12,21	GLUD1	43,48	glutamate	GLUD1	CHEBI:29987	2746	Chemical	Gene	genes|amod|START_ENTITY genes|dep|END_ENTITY	Three human glutamate dehydrogenase genes -LRB- GLUD1 , GLUDP2 , and GLUDP3 -RRB- are located on chromosome 10q , but are not closely physically linked .
12742085	0	glutamate	51,60	GLUD2	160,165	glutamate	GLUD2	CHEBI:29987	2747	Chemical	Gene	dehydrogenases|compound|START_ENTITY relationships|nmod|dehydrogenases Study|nmod|relationships reveals|nsubj|Study reveals|xcomp|isoenzyme isoenzyme|nsubj|mechanisms mechanisms|nmod|regulation regulation|nmod|tissue-specific tissue-specific|appos|END_ENTITY	Study of structure-function relationships in human glutamate dehydrogenases reveals novel molecular mechanisms for the regulation of the nerve tissue-specific -LRB- GLUD2 -RRB- isoenzyme .
19428807	0	glutamate	16,25	GLUD2	10,15	glutamate	GLUD2	CHEBI:29987	2747	Chemical	Gene	dehydrogenase|compound|START_ENTITY dehydrogenase|compound|END_ENTITY	The human GLUD2 glutamate dehydrogenase : localization and functional aspects .
19826450	0	glutamate	34,43	GLUD2	28,33	glutamate	GLUD2	CHEBI:29987	2747	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|compound|END_ENTITY	Gain-of-function variant in GLUD2 glutamate dehydrogenase modifies Parkinson 's _ disease onset .
22709674	0	glutamate	26,35	GLUD2	20,25	glutamate	GLUD2	CHEBI:29987	2747	Chemical	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of human GLUD2 glutamate dehydrogenase in human tissues : functional implications .
11442354	0	glutamate	36,45	GLUR2	64,69	glutamate	GLUR2	CHEBI:29987	2891	Chemical	Gene	receptor|amod|START_ENTITY site|nmod|receptor editing|nmod|site subunits|nsubj|editing subunits|dobj|END_ENTITY	RNA editing at the Q/R site for the glutamate receptor subunits GLUR2 , GLUR5 , and GLUR6 in hippocampus and temporal cortex from epileptic patients .
15090029	0	glutamate	131,140	GLUR2	8,13	glutamate	GLUR2	CHEBI:29987	14800(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY remaining|xcomp|receptors affects|xcomp|remaining affects|nsubj|Loss Loss|nmod|subunit subunit|compound|END_ENTITY	Loss of GLUR2 alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic_acid receptor subunit differentially affects remaining synaptic glutamate receptors in cerebellum and cochlear nuclei .
17628700	0	glutamate	65,74	GLUR3	44,49	glutamate	GLUR3	CHEBI:29987	2892	Chemical	Gene	migration|amod|START_ENTITY Expression|nmod|migration Expression|nmod|END_ENTITY	Expression of ionotropic glutamate receptor GLUR3 and effects of glutamate on MBP - and MOG-specific lymphocyte activation and chemotactic migration in multiple_sclerosis patients .
7959697	0	glutamate	42,51	GLUR5	36,41	glutamate	GLUR5	CHEBI:29987	2897	Chemical	Gene	START_ENTITY|nsubj|mapping mapping|nmod|END_ENTITY	Genetic and physical mapping of the GLUR5 glutamate receptor gene on human chromosome 21 .
19003990	0	glutamate	22,31	GLuR3	50,55	glutamate	GLuR3	CHEBI:29987	2892	Chemical	Gene	START_ENTITY|dobj|domain domain|nmod|END_ENTITY	Structure of the S1S2 glutamate binding domain of GLuR3 .
22645130	0	glutamate	16,25	GPR30	0,5	glutamate	GPR30	CHEBI:29987	171104(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	GPR30 regulates glutamate transporter GLT-1 expression in rat primary astrocytes .
16523673	0	glutamate	45,54	GRIA1	111,116	glutamate	GRIA1	CHEBI:29987	2890	Chemical	Gene	EAAT2|amod|START_ENTITY involvement|nmod|EAAT2 Analysis|nmod|involvement genes|nsubj|Analysis genes|dobj|END_ENTITY	-LSB- Analysis of the possible involvement of the glutamate transporter gene EAAT2 and the glutamate receptor genes GRIA1 and GRIA2 in pathogenesis of motor_neuron_disease in the Russian population -RSB- .
17847003	0	glutamate	27,36	GRIK2	54,59	glutamate	GRIK2	CHEBI:29987	2898	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A defect in the ionotropic glutamate receptor 6 gene -LRB- GRIK2 -RRB- is associated with autosomal recessive mental_retardation .
11986986	0	glutamate	35,44	GRIK3	65,70	glutamate	GRIK3	CHEBI:29987	2899	Chemical	Gene	receptor|compound|START_ENTITY Association|nmod|receptor kainate|nsubj|Association kainate|dobj|polymorphism polymorphism|compound|END_ENTITY	Association between the ionotropic glutamate receptor kainate 3 -LRB- GRIK3 -RRB- ser310ala polymorphism and schizophrenia .
16314883	0	glutamate	11,20	GRIK3	35,40	glutamate	GRIK3	CHEBI:29987	2899	Chemical	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	Ionotropic glutamate receptor gene GRIK3 SER310ALA functional polymorphism is related to delirium tremens in alcoholics .
16356644	0	glutamate	53,62	GRIK3	72,77	glutamate	GRIK3	CHEBI:29987	2899	Chemical	Gene	Ser310Ala|amod|START_ENTITY Ser310Ala|compound|END_ENTITY	Family-based and case-control association studies of glutamate receptor GRIK3 Ser310Ala polymorphism in Polish patients and families with alcohol_dependence .
19921975	0	glutamate	35,44	GRIK3	64,69	glutamate	GRIK3	CHEBI:29987	2899	Chemical	Gene	kainate3|amod|START_ENTITY kainate3|appos|END_ENTITY	Association between the ionotropic glutamate receptor kainate3 -LRB- GRIK3 -RRB- Ser310Ala polymorphism and schizophrenia in the Indian population .
23006490	0	glutamate	39,48	GRIK3	58,63	glutamate	GRIK3	CHEBI:29987	2899	Chemical	Gene	Ser310Ala|amod|START_ENTITY Ser310Ala|compound|END_ENTITY	Family-based and case-control study of glutamate receptor GRIK3 Ser310Ala polymorphism in alcohol_dependence .
24449200	0	glutamate	77,86	GRIK3	26,31	glutamate	GRIK3	CHEBI:29987	2899	Chemical	Gene	receptors|compound|START_ENTITY implication|nmod|receptors deletion|dep|implication deletion|nmod|END_ENTITY	1p34 .3 deletion involving GRIK3 : Further clinical implication of GRIK family glutamate receptors in the pathogenesis of developmental_delay .
16819533	0	glutamate	70,79	GRIK4	95,100	glutamate	GRIK4	CHEBI:29987	2900	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cytogenetic and genetic evidence supports a role for the kainate-type glutamate receptor gene , GRIK4 , in schizophrenia and bipolar_disorder .
18824690	0	glutamate	43,52	GRIK4	37,42	glutamate	GRIK4	CHEBI:29987	2900	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	A common variant in the 3 ` UTR of the GRIK4 glutamate receptor gene affects transcript abundance and protects against bipolar_disorder .
7527545	0	glutamate	23,32	GRIK4	64,69	glutamate	GRIK4	CHEBI:29987	2900	Chemical	Gene	receptor|amod|START_ENTITY encoding|dobj|receptor genes|acl|encoding subunits|nsubj|genes subunits|ccomp|located located|nsubjpass|KA1 KA1|appos|END_ENTITY	The genes encoding the glutamate receptor subunits KA1 and KA2 -LRB- GRIK4 and GRIK5 -RRB- are located on separate chromosomes in human , mouse , and rat .
21507155	0	glutamate	56,65	GRIN2A	89,95	glutamate	GRIN2A	CHEBI:29987	2903	Chemical	Gene	receptor|amod|START_ENTITY promoter|nmod|receptor polymorphism|nmod|promoter Association|nmod|polymorphism subunit|nsubj|Association subunit|dobj|gene gene|appos|END_ENTITY	Association between a polymorphism in the promoter of a glutamate receptor subunit gene -LRB- GRIN2A -RRB- and alcoholism .
23940648	0	glutamate	30,39	GRIN2A	75,81	glutamate	GRIN2A	CHEBI:29987	2903	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Analysis of variations in the glutamate receptor , N-methyl_D-aspartate 2A -LRB- GRIN2A -RRB- gene reveals their relative importance as genetic susceptibility factors for heroin_addiction .
15083261	0	glutamate	17,26	GRIN2B	57,63	glutamate	GRIN2B	CHEBI:29987	2904	Chemical	Gene	Association|nmod|START_ENTITY subunit|nsubj|Association subunit|dobj|gene gene|appos|END_ENTITY	Association of a glutamate -LRB- NMDA -RRB- subunit receptor gene -LRB- GRIN2B -RRB- with obsessive-compulsive_disorder : a preliminary study .
17010153	0	glutamate	19,28	GRIN2B	51,57	glutamate	GRIN2B	CHEBI:29987	14812(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY Association|nmod|receptor subunit|nsubj|Association subunit|dobj|END_ENTITY	Association of the glutamate receptor subunit gene GRIN2B with attention-deficit/hyperactivity _ disorder .
19665356	0	glutamate	36,45	GRIN3A	85,91	glutamate	GRIN3A	CHEBI:29987	116443	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Exomic sequencing of the ionotropic glutamate receptor N-methyl-D-aspartate 3A gene -LRB- GRIN3A -RRB- reveals no association with schizophrenia .
15102938	0	glutamate	33,42	GRK2	107,111	glutamate	GRK2	CHEBI:29987	156	Chemical	Gene	receptor|compound|START_ENTITY Regulation|nmod|receptor coupled|nsubj|Regulation coupled|dobj|kinase kinase|appos|END_ENTITY	Regulation of mGlu4 metabotropic glutamate receptor signaling by type-2 G-protein coupled receptor kinase -LRB- GRK2 -RRB- .
23313319	0	glutamate	39,48	GRK2	10,14	glutamate	GRK2	CHEBI:29987	110355(Tax:10090)	Chemical	Gene	transport|amod|START_ENTITY END_ENTITY|nmod|transport	Astrocyte GRK2 as a novel regulator of glutamate transport and brain_damage .
19924463	0	glutamate	17,26	GRM1	39,43	glutamate	GRM1	CHEBI:29987	14816(Tax:10090)	Chemical	Gene	START_ENTITY|dep|receptor receptor|nummod|END_ENTITY	The metabotropic glutamate receptor 1 , GRM1 : evaluation as a candidate gene for inherited_forms_of_cerebellar_ataxia .
23303475	0	glutamate	55,64	GRM1	21,25	glutamate	GRM1	CHEBI:29987	2911	Chemical	Gene	localization|compound|START_ENTITY alter|dobj|localization alter|nsubj|mutations mutations|nmod|END_ENTITY	Somatic mutations in GRM1 in cancer alter metabotropic glutamate receptor 1 intracellular localization and signaling .
23481697	0	glutamate	88,97	GRM1	36,40	glutamate	GRM1	CHEBI:29987	2911	Chemical	Gene	receptor|compound|START_ENTITY variant|nmod|receptor express|dobj|variant express|nmod|END_ENTITY	Two newly identified exons in human GRM1 express a novel splice variant of metabotropic glutamate 1 receptor .
11317221	0	glutamate	54,63	GRM2	86,90	glutamate	GRM2	CHEBI:29987	2912	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Structure and polymorphisms of the human metabotropic glutamate receptor type 2 gene -LRB- GRM2 -RRB- : analysis of association with schizophrenia .
11840499	0	glutamate	19,28	GRM2	46,50	glutamate	GRM2	CHEBI:29987	2912	Chemical	Gene	receptor|compound|START_ENTITY receptor|dep|gene gene|appos|END_ENTITY	Human metabotropic glutamate receptor 2 gene -LRB- GRM2 -RRB- : chromosomal sublocalization -LRB- 3p21.1-p21 .2 -RRB- and genomic organization .
18720515	0	glutamate	34,43	GRM2	74,78	glutamate	GRM2	CHEBI:29987	108068(Tax:10090)	Chemical	Gene	receptors|amod|START_ENTITY expression|nmod|receptors expression|nmod|mice mice|compound|END_ENTITY	Altered hippocampal expression of glutamate receptors and transporters in GRM2 and GRM3 knockout mice .
19386277	0	glutamate	46,55	GRM2	72,76	glutamate	GRM2	CHEBI:29987	2912	Chemical	Gene	START_ENTITY|dobj|genes genes|appos|END_ENTITY	Association analysis of group II metabotropic glutamate receptor genes -LRB- GRM2 and GRM3 -RRB- with mood_disorders and fluvoxamine response in a Japanese population .
25158312	0	glutamate	34,43	GRM2	103,107	glutamate	GRM2	CHEBI:29987	108068(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY role|nmod|receptors role|dep|studies studies|nmod|END_ENTITY	The role of group II metabotropic glutamate receptors in cognition and anxiety : Comparative studies in GRM2 -LRB- - / - -RRB- , GRM3 -LRB- - / - -RRB- and GRM2/3 -LRB- - / - -RRB- knockout mice .
11840505	0	glutamate	13,22	GRM3	35,39	glutamate	GRM3	CHEBI:29987	2913	Chemical	Gene	START_ENTITY|dobj|receptor receptor|appos|END_ENTITY	Metabotropic glutamate receptor 3 -LRB- GRM3 -RRB- gene variation is not associated with schizophrenia or bipolar_affective_disorder in the German population .
12782962	0	glutamate	59,68	GRM3	91,95	glutamate	GRM3	CHEBI:29987	2913	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Positive associations of polymorphisms in the metabotropic glutamate receptor type 3 gene -LRB- GRM3 -RRB- with schizophrenia .
16904291	0	glutamate	40,49	GRM3	72,76	glutamate	GRM3	CHEBI:29987	2913	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	No association between the metabotropic glutamate receptor type 3 gene -LRB- GRM3 -RRB- and schizophrenia in a Japanese population .
21344500	0	glutamate	44,53	GRM3	69,73	glutamate	GRM3	CHEBI:29987	2913	Chemical	Gene	gene|amod|START_ENTITY Association|nmod|gene Association|appos|END_ENTITY	Association between type-three metabotropic glutamate receptor gene -LRB- GRM3 -RRB- variants and symptom presentation in treatment refractory schizophrenia .
24585043	0	glutamate	65,74	GRM3	84,88	glutamate	GRM3	CHEBI:29987	2913	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Association of single-nucleotide polymorphisms in a metabotropic glutamate receptor GRM3 gene subunit to alcohol-dependent male subjects .
25096017	0	glutamate	56,65	GRM3	76,80	glutamate	GRM3	CHEBI:29987	2913	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Pharmacogenetic associations of the type-3 metabotropic glutamate receptor -LRB- GRM3 -RRB- gene with working memory and clinical symptom response to antipsychotics in first-episode schizophrenia .
8824806	0	glutamate	33,42	GRM3	59,63	glutamate	GRM3	CHEBI:29987	2913	Chemical	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Localization of two metabotropic glutamate receptor genes , GRM3 and GRM8 , to human chromosome 7q .
18329248	0	glutamate	35,44	GRM7	62,66	glutamate	GRM7	CHEBI:29987	2917	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A polymorphism of the metabotropic glutamate receptor mGluR7 -LRB- GRM7 -RRB- gene is associated with schizophrenia .
25921429	0	glutamate	38,47	GRM7	60,64	glutamate	GRM7	D018698	2917	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Rare de novo deletion of metabotropic glutamate receptor 7 -LRB- GRM7 -RRB- gene in a patient with autism_spectrum_disorder .
15211621	0	glutamate	59,68	GRM8	91,95	glutamate	GRM8	CHEBI:29987	2918	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Positive associations of polymorphisms in the metabotropic glutamate receptor type 8 gene -LRB- GRM8 -RRB- with schizophrenia .
18618593	0	glutamate	52,61	GRM8	77,81	glutamate	GRM8	CHEBI:29987	2918	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of single nucleotide polymorphisms in a glutamate receptor gene -LRB- GRM8 -RRB- with theta power of event-related oscillations and alcohol_dependence .
9299241	0	glutamate	23,32	GRM8	45,49	glutamate	GRM8	CHEBI:29987	2918	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	The human metabotropic glutamate receptor 8 -LRB- GRM8 -RRB- gene : a disproportionately large gene located at 7q31.3-q32 .1 .
12101219	0	glutamate	55,64	G_protein-coupled_receptor_kinase_2	87,122	glutamate	G protein-coupled receptor kinase 2	CHEBI:29987	156	Chemical	Gene	receptor|compound|START_ENTITY regulation|nmod|receptor regulation|acl|signaling signaling|nmod|END_ENTITY	Phosphorylation-independent regulation of metabotropic glutamate receptor signaling by G_protein-coupled_receptor_kinase_2 .
23494575	0	glutamate	61,70	G_protein-coupled_receptor_kinase_2	0,35	glutamate	G protein-coupled receptor kinase 2	CHEBI:29987	156	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	G_protein-coupled_receptor_kinase_2 and group I metabotropic glutamate receptors mediate inflammation-induced sensitization to excitotoxic neurodegeneration .
23705503	0	glutamate	61,70	G_protein-coupled_receptor_kinase_2	85,120	glutamate	G protein-coupled receptor kinase 2	CHEBI:29987	156	Chemical	Gene	desensitization|nmod|START_ENTITY receptor|nsubj|desensitization receptor|nmod|END_ENTITY	-LSB- Phosphorylation-independent desensitization of metabotropic glutamate receptor 5 by G_protein-coupled_receptor_kinase_2 in HEK 293 cells -RSB- .
15322701	0	glutamate	28,37	G_protein_coupled_receptor	52,78	glutamate	G protein coupled receptor	CHEBI:29987	23890(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|receptor receptor|appos|END_ENTITY	Involvement of metabotropic glutamate receptor 1 , a G_protein_coupled_receptor , in melanoma development .
25577412	0	glutamate	20,29	Gdnf	75,79	glutamate	Gdnf	CHEBI:29987	14573(Tax:10090)	Chemical	Gene	neurotransmission|amod|START_ENTITY neurotransmission|nmod|nigra nigra|nmod|END_ENTITY	Effects of aging on glutamate neurotransmission in the substantia nigra of Gdnf heterozygous mice .
12558972	0	glutamate	12,21	Glt-1	42,47	glutamate	Glt-1	CHEBI:29987	6506	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|EAAT2 EAAT2|appos|END_ENTITY	The ` glial ' glutamate transporter , EAAT2 -LRB- Glt-1 -RRB- accounts for high affinity glutamate uptake into adult rodent nerve endings .
12558972	0	glutamate	76,85	Glt-1	42,47	glutamate	Glt-1	CHEBI:29987	6506	Chemical	Gene	uptake|compound|START_ENTITY accounts|nmod|uptake accounts|nsubj|transporter transporter|appos|EAAT2 EAAT2|appos|END_ENTITY	The ` glial ' glutamate transporter , EAAT2 -LRB- Glt-1 -RRB- accounts for high affinity glutamate uptake into adult rodent nerve endings .
26697981	0	glutamate	5,14	Glt1	0,4	glutamate	Glt1	D018698	29482(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Glt1 glutamate receptor mediates the establishment and perpetuation of chronic visceral_pain in an animal model of stress-induced bladder_hyperalgesia .
21639859	0	glutamate	25,34	GluA1	44,49	glutamate	GluA1	CHEBI:29987	2890	Chemical	Gene	receptor|amod|START_ENTITY structure|nmod|receptor END_ENTITY|nsubj|structure	Crystal structure of the glutamate receptor GluA1 N-terminal domain .
26228348	0	glutamate	86,95	GluA1	105,110	glutamate	GluA1	D018698	2890	Chemical	Gene	subunits|compound|START_ENTITY subunits|amod|END_ENTITY	Propranolol decreases retention of fear memory by modulating the stability of surface glutamate receptor GluA1 subunits in the lateral amygdala .
21248105	0	glutamate	37,46	GluA2	0,5	glutamate	GluA2	CHEBI:29987	2891	Chemical	Gene	depression|amod|START_ENTITY regulates|dobj|depression regulates|nsubj|END_ENTITY	GluA2 -LRB- GluR2 -RRB- regulates metabotropic glutamate receptor-dependent long-term depression through N-cadherin-dependent and cofilin-mediated actin reorganization .
22266371	0	glutamate	11,20	GluA2	0,5	glutamate	GluA2	CHEBI:29987	2891	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	GluA2 AMPA glutamate receptor subunit exhibits codon 607 Q/R RNA editing in the lens .
23076153	0	glutamate	141,150	GluA2	161,166	glutamate	GluA2	CHEBI:29987	2891	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	The structure of -LRB- - -RRB- - kaitocephalin bound to the ligand binding domain of the -LRB- S -RRB- - a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic_acid -LRB- AMPA -RRB- / glutamate receptor , GluA2 .
22113500	0	glutamate	70,79	GluD2	20,25	glutamate	GluD2	CHEBI:29987	104277(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY use|dobj|receptor ins|acl:relcl|use ins|nmod|END_ENTITY	The ins and outs of GluD2 -- why and how Purkinje cells use the special glutamate receptor .
23564161	0	glutamate	82,91	GluD2	29,34	glutamate	GluD2	CHEBI:29987	14804(Tax:10090)	Chemical	Gene	release|amod|START_ENTITY channel|dobj|release channel|nsubj|Contribution Contribution|nmod|END_ENTITY	Contribution of postsynaptic GluD2 to presynaptic R-type Ca -LRB- 2 + -RRB- channel function , glutamate release and long-term potentiation at parallel fiber to Purkinje cell synapses .
24357660	0	glutamate	20,29	GluD2	70,75	glutamate	GluD2	CHEBI:29987	2747	Chemical	Gene	receptors|compound|START_ENTITY trigger|nsubj|receptors trigger|dobj|gating gating|nmod|receptors receptors|amod|END_ENTITY	Type 1 metabotropic glutamate receptors -LRB- mGlu1 -RRB- trigger the gating of GluD2 delta glutamate receptors .
24357660	0	glutamate	82,91	GluD2	70,75	glutamate	GluD2	CHEBI:29987	2747	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Type 1 metabotropic glutamate receptors -LRB- mGlu1 -RRB- trigger the gating of GluD2 delta glutamate receptors .
15344919	0	glutamate	32,41	GluR-A	51,57	glutamate	GluR-A	CHEBI:29987	14799(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY aggression|nmod|receptor END_ENTITY|nsubj|aggression	Reduced aggression in AMPA-type glutamate receptor GluR-A subunit-deficient mice .
18492725	0	glutamate	57,66	GluR-A	25,31	glutamate	GluR-A	CHEBI:29987	14799(Tax:10090)	Chemical	Gene	hypothesis|amod|START_ENTITY model|dobj|hypothesis 1|acl:relcl|model 1|appos|END_ENTITY	AMPA receptor subunit 1 -LRB- GluR-A -RRB- knockout mice model the glutamate hypothesis of depression .
2176160	0	glutamate	52,61	GluR-A	80,86	glutamate	GluR-A	CHEBI:29987	50592(Tax:10116)	Chemical	Gene	subunit|compound|START_ENTITY subunit|appos|END_ENTITY	Antibodies to a C-terminal peptide of the rat brain glutamate receptor subunit , GluR-A , recognize a subpopulation of AMPA binding sites but not kainate sites .
8521834	0	glutamate	35,44	GluR-D	28,34	glutamate	GluR-D	CHEBI:29987	2893	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Purification of recombinant GluR-D glutamate receptor produced in Sf21 insect cells .
10693949	0	glutamate	6,15	GluR1	0,5	glutamate	GluR1	CHEBI:29987	2890	Chemical	Gene	subunit|amod|START_ENTITY subunit|nummod|END_ENTITY	GluR1 glutamate receptor subunit is regulated differentially in the primate basal ganglia following nigrostriatal dopamine denervation .
11340067	0	glutamate	37,46	GluR1	31,36	glutamate	GluR1	CHEBI:29987	50592(Tax:10116)	Chemical	Gene	promoter|amod|START_ENTITY promoter|amod|END_ENTITY	Functional organization of the GluR1 glutamate receptor promoter .
1371672	0	glutamate	13,22	GluR1	7,12	glutamate	GluR1	CHEBI:29987	2890	Chemical	Gene	subunit|amod|START_ENTITY subunit|amod|END_ENTITY	In the GluR1 glutamate receptor subunit a glutamine to histidine point mutation suppresses inward rectification but not calcium permeability .
15531103	0	glutamate	27,36	GluR1	91,96	glutamate	GluR1	CHEBI:29987	2890	Chemical	Gene	receptors|compound|START_ENTITY Activation|nmod|receptors alter|nsubj|Activation alter|dobj|state state|nmod|subunit subunit|compound|END_ENTITY	Activation of metabotropic glutamate receptors does not alter the phosphorylation state of GluR1 AMPA receptor subunit at serine 845 in perirhinal cortical neurons .
1648187	0	glutamate	77,86	GluR1	55,60	glutamate	GluR1	CHEBI:29987	100294513(Tax:8355)	Chemical	Gene	receptor-channel|amod|START_ENTITY subunit|nmod|receptor-channel END_ENTITY|appos|subunit	Electrophysiological and pharmacological properties of GluR1 , a subunit of a glutamate receptor-channel expressed in Xenopus oocytes .
1652625	0	glutamate	45,54	GluR1	72,77	glutamate	GluR1	CHEBI:29987	50592(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY characterization|nmod|receptor subunit|nsubj|characterization subunit|dobj|END_ENTITY	The characterization and localization of the glutamate receptor subunit GluR1 in the rat brain .
17446041	0	glutamate	75,84	GluR1	33,38	glutamate	GluR1	CHEBI:29987	50592(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY subunits|nmod|receptor subunits|nsubj|localization localization|nmod|END_ENTITY	Differential localization of the GluR1 and GluR2 subunits of the AMPA-type glutamate receptor among striatal neuron types in rats .
18292343	3	glutamate	318,327	GluR1	406,411	glutamate	c-fos	CHEBI:29987	14281(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY dynamics|nmod|receptors dynamics|acl|induced induced|advcl|learning learning|advcl|using using|advcl|expressing expressing|dobj|subunit subunit|amod|END_ENTITY	We studied the dynamics of newly synthesized AMPA-type glutamate receptors -LRB- AMPARs -RRB- induced with learning using transgenic_mice expressing the GluR1 subunit fused to green fluorescent protein -LRB- GFP-GluR1 -RRB- under control of the c-fos promoter .
19258522	0	glutamate	35,44	GluR1	91,96	glutamate	GluR1	CHEBI:29987	50592(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY Activation|nmod|receptors increases|nsubj|Activation increases|dobj|phosphorylation phosphorylation|nmod|receptors receptors|amod|END_ENTITY	Activation of group I metabotropic glutamate receptors increases serine phosphorylation of GluR1 alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic_acid receptors in the rat dorsal striatum .
24797327	0	glutamate	38,47	GluR1	93,98	glutamate	GluR1	CHEBI:29987	14799(Tax:10090)	Chemical	Gene	type|amod|START_ENTITY role|nmod|type unveils|dobj|role unveils|advcl|regulating regulating|dobj|trafficking trafficking|amod|END_ENTITY	Isoflurane unveils a critical role of glutamate transporter type 3 in regulating hippocampal GluR1 trafficking and context-related learning and memory in mice .
25792422	0	glutamate	10,19	GluR1	45,50	glutamate	GluR1	D018698	50592(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Prolonged glutamate excitotoxicity increases GluR1 immunoreactivity but decreases mRNA of GluR1 and associated regulatory proteins in dissociated rat retinae in vitro .
25792422	0	glutamate	10,19	GluR1	45,50	glutamate	GluR1	D018698	50592(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Prolonged glutamate excitotoxicity increases GluR1 immunoreactivity but decreases mRNA of GluR1 and associated regulatory proteins in dissociated rat retinae in vitro .
7518502	0	glutamate	31,40	GluR1	25,30	glutamate	GluR1	CHEBI:29987	50592(Tax:10116)	Chemical	Gene	subunit|amod|START_ENTITY subunit|amod|END_ENTITY	Membrane topology of the GluR1 glutamate receptor subunit : epitope mapping by site-directed antipeptide antibodies .
7609609	0	glutamate	48,57	GluR1	68,73	glutamate	GluR1	CHEBI:29987	2890	Chemical	Gene	encoding|dobj|START_ENTITY mRNAs|acl|encoding expression|nmod|mRNAs receptors|nsubj|expression receptors|dobj|END_ENTITY	Decreased expression of mRNAs encoding non-NMDA glutamate receptors GluR1 and GluR2 in medial temporal lobe neurons in schizophrenia .
8230318	0	glutamate	31,40	GluR1	101,106	glutamate	GluR1	CHEBI:29987	14799(Tax:10090)	Chemical	Gene	Expression|nmod|START_ENTITY receptor|nsubj|Expression receptor|dobj|END_ENTITY	Expression of the metabotropic glutamate receptor mGluR1 alpha and the ionotropic glutamate receptor GluR1 in the brain during the postnatal development of normal mouse and in the cerebellum from mutant mice .
8478682	0	glutamate	14,23	GluR1	84,89	glutamate	GluR1	CHEBI:29987	2890	Chemical	Gene	genes|amod|START_ENTITY Expression|nmod|genes Expression|dep|localization localization|nmod|END_ENTITY	Expression of glutamate receptor genes in the mammalian retina : the localization of GluR1 through GluR7 mRNAs .
8504792	0	glutamate	71,80	GluR1	91,96	glutamate	GluR1	CHEBI:29987	50592(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Differential effects of kindled and electrically induced seizures on a glutamate receptor -LRB- GluR1 -RRB- gene expression .
8526855	0	glutamate	60,69	GluR1	87,92	glutamate	GluR1	CHEBI:29987	50592(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY topology|nmod|receptor investigation|nmod|topology subunit|nsubj|investigation subunit|dobj|END_ENTITY	An investigation of the membrane topology of the ionotropic glutamate receptor subunit GluR1 in a cell-free system .
8670110	0	glutamate	146,155	GluR1	173,178	glutamate	GluR1	CHEBI:29987	2890	Chemical	Gene	receptor|compound|START_ENTITY domains|nmod|receptor expression|nmod|domains subunit|nsubj|expression subunit|dobj|END_ENTITY	Characterization , cell-surface expression and ligand-binding properties of different truncated N-terminal extracellular domains of the ionotropic glutamate receptor subunit GluR1 .
8725347	1	glutamate	145,154	GluR1	139,144	glutamate	GluR2	CHEBI:29987	29627(Tax:10116)	Chemical	Gene	subunit|amod|START_ENTITY subunit|amod|END_ENTITY	Recent in vitro studies suggest that inhibitory interneurons in cortex may express the GluR1 glutamate receptor subunit in the absence of GluR2 , leading to calcium-permeable alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate -LRB- AMPA -RRB- channels .
8923524	0	glutamate	20,29	GluR1	47,52	glutamate	GluR1	CHEBI:29987	2890	Chemical	Gene	receptor|amod|START_ENTITY Localization|nmod|receptor subunit|nsubj|Localization subunit|dobj|END_ENTITY	Localization of the glutamate receptor subunit GluR1 on the surface of living and within cultured hippocampal neurons .
8968949	0	glutamate	32,41	GluR1	60,65	glutamate	GluR1	CHEBI:29987	2890	Chemical	Gene	receptor|amod|START_ENTITY expression|nmod|receptor subtypes|nsubj|expression subtypes|dobj|END_ENTITY	Regional gene expression of the glutamate receptor subtypes GluR1 , GluR2 , and GluR3 in human postmortem brain .
9120436	0	glutamate	87,96	GluR1	115,120	glutamate	GluR1	CHEBI:29987	2890	Chemical	Gene	subunit|amod|START_ENTITY subunit|appos|END_ENTITY	Kainic_acid induced excitotoxicity and cfos expression in fibroblasts transfected with glutamate receptor subunit , GluR1 .
9462876	0	glutamate	50,59	GluR1	25,30	glutamate	GluR1	CHEBI:29987	50592(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|localization localization|nmod|END_ENTITY	Cellular localization of GluR1 , GluR2/3 and GluR4 glutamate receptor subunits in neurons of the rat neostriatum .
9753141	0	glutamate	44,53	GluR1	0,5	glutamate	GluR1	CHEBI:29987	50592(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY subunits|nmod|receptor subunits|amod|END_ENTITY	GluR1 and GluR2/3 subunits of the AMPA-type glutamate receptor are associated with particular types of neurone in laminae I-III of the spinal dorsal horn of the rat .
10515169	0	glutamate	62,71	GluR2	56,61	glutamate	GluR2	CHEBI:29987	29627(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Expression of mRNAs encoding flip isoforms of GluR1 and GluR2 glutamate receptors is increased in rat hippocampus in epilepsy induced by tetanus toxin .
10551584	0	glutamate	12,21	GluR2	166,171	glutamate	GluR2	CHEBI:29987	14800(Tax:10090)	Chemical	Gene	receptors|amod|START_ENTITY Blockade|nmod|receptors Blockade|dep|sensitivity sensitivity|nmod|mice mice|amod|END_ENTITY	Blockade of glutamate receptors and barbiturate anesthesia : increased sensitivity to pentobarbital-induced anesthesia despite reduced inhibition of AMPA receptors in GluR2 null mutant mice .
10614590	0	glutamate	15,24	GluR2	43,48	glutamate	GluR2	CHEBI:29987	2891	Chemical	Gene	receptor|compound|START_ENTITY subunits|nsubj|receptor subunits|dobj|END_ENTITY	AMPA-selective glutamate receptor subunits GluR2 and GluR4 in the cat retina : an immunocytochemical study .
10717434	0	glutamate	13,22	GluR2	23,28	glutamate	GluR2	CHEBI:29987	29627(Tax:10116)	Chemical	Gene	neurons|amod|START_ENTITY neurons|amod|END_ENTITY	Depletion of glutamate GluR2 receptor-containing neurons in the rat neostriatum by specific immunotoxin .
11086992	0	glutamate	62,71	GluR2	108,113	glutamate	GluR2	CHEBI:29987	2891	Chemical	Gene	receptor|compound|START_ENTITY Mechanisms|nmod|receptor Mechanisms|dep|structures structures|nmod|core core|amod|END_ENTITY	Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor : crystal structures of the GluR2 ligand binding core .
11844485	0	glutamate	40,49	GluR2	23,28	glutamate	GluR2	CHEBI:29987	2891	Chemical	Gene	START_ENTITY|nsubj|changes changes|nmod|END_ENTITY	Age-related changes in GluR2 and NMDAR1 glutamate receptor subunit protein immunoreactivity in corticocortically projecting neurons in macaque and patas monkeys .
14561864	0	glutamate	22,31	GluR2	94,99	glutamate	GluR2	CHEBI:29987	14800(Tax:10090)	Chemical	Gene	complexes|amod|START_ENTITY formation|nmod|complexes formation|acl|lacking lacking|dobj|subunit subunit|amod|END_ENTITY	Aberrant formation of glutamate receptor complexes in hippocampal neurons of mice lacking the GluR2 AMPA receptor subunit .
14573529	0	glutamate	87,96	GluR2	29,34	glutamate	GluR2	CHEBI:29987	14800(Tax:10090)	Chemical	Gene	mice|amod|START_ENTITY evidence|nmod|mice subunits|dobj|evidence subunits|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of AMPA receptor GluR2 subunits in stimulus-reward learning : evidence from glutamate receptor gria2 knock-out mice .
15100219	0	glutamate	76,85	GluR2	59,64	glutamate	GluR2	CHEBI:29987	2891	Chemical	Gene	receptors|amod|START_ENTITY Chemistry|nmod|receptors Chemistry|nmod|domain domain|nmod|subtype subtype|amod|END_ENTITY	Chemistry and conformation of the ligand-binding domain of GluR2 subtype of glutamate receptors .
15736951	0	glutamate	108,117	GluR2	65,70	glutamate	GluR2	CHEBI:29987	2891	Chemical	Gene	bound|nmod|START_ENTITY bound|nsubj|receptor receptor|amod|END_ENTITY	Microsecond-to-millisecond conformational dynamics demarcate the GluR2 glutamate receptor bound to agonists glutamate , quisqualate , and AMPA .
15736951	0	glutamate	71,80	GluR2	65,70	glutamate	GluR2	CHEBI:29987	2891	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Microsecond-to-millisecond conformational dynamics demarcate the GluR2 glutamate receptor bound to agonists glutamate , quisqualate , and AMPA .
17298385	8	glutamate	1465,1474	GluR2	1492,1497	glutamate	GluR2	CHEBI:29987	2891	Chemical	Gene	receptor|amod|START_ENTITY levels|nmod|receptor measured|nsubj|levels measured|parataxis|increased increased|nsubj|END_ENTITY	mRNA levels of the glutamate receptor subunit GluR2 increased by 60 % , measured 18 h after a 15 min exposure to -LRB- - -RRB- epicatechin and this translated into an increase in GluR2 protein .
17337449	0	glutamate	21,30	GluR2	49,54	glutamate	GluR2	CHEBI:29987	2891	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Dynamics of the S1S2 glutamate binding domain of GluR2 measured using 19F NMR spectroscopy .
17929944	0	glutamate	40,49	GluR2	34,39	glutamate	GluR2	CHEBI:29987	2891	Chemical	Gene	channel|amod|START_ENTITY channel|amod|END_ENTITY	RNA aptamers selected against the GluR2 glutamate receptor channel .
19205024	0	glutamate	90,99	GluR2	84,89	glutamate	GluR2	CHEBI:29987	2891	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Modeling of peptides connecting the ligand-binding and transmembrane domains in the GluR2 glutamate receptor .
19284741	0	glutamate	131,140	GluR2	32,37	glutamate	GluR2	CHEBI:29987	2891	Chemical	Gene	domain|compound|START_ENTITY antagonists|nmod|domain complex|nmod|antagonists structure|nmod|complex Mechanisms|dep|structure Mechanisms|nmod|antagonism antagonism|nmod|receptor receptor|compound|END_ENTITY	Mechanisms of antagonism of the GluR2 AMPA receptor : structure and dynamics of the complex of two willardiine antagonists with the glutamate binding domain .
19651138	0	glutamate	120,129	GluR2	25,30	glutamate	GluR2	CHEBI:29987	2891	Chemical	Gene	receptors|compound|START_ENTITY architecture|nmod|receptors provides|nmod|architecture provides|nsubj|structure structure|nmod|domain domain|amod|END_ENTITY	Crystal structure of the GluR2 amino-terminal domain provides insights into the architecture and assembly of ionotropic glutamate receptors .
19908285	0	glutamate	96,105	GluR2	15,20	glutamate	GluR2	CHEBI:29987	29627(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Alterations Alterations|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Alterations in GluR2 AMPA receptor phosphorylation at serine 880 following group I metabotropic glutamate receptor stimulation in the rat dorsal striatum .
21248105	0	glutamate	37,46	GluR2	7,12	glutamate	GluR2	CHEBI:29987	2891	Chemical	Gene	depression|amod|START_ENTITY regulates|dobj|depression regulates|nsubj|GluA2 GluA2|appos|END_ENTITY	GluA2 -LRB- GluR2 -RRB- regulates metabotropic glutamate receptor-dependent long-term depression through N-cadherin-dependent and cofilin-mediated actin reorganization .
23719929	0	glutamate	25,34	GluR2	52,57	glutamate	GluR2	CHEBI:29987	2891	Chemical	Gene	receptor|compound|START_ENTITY Involvement|nmod|receptor subunit|nsubj|Involvement subunit|dobj|expression expression|amod|END_ENTITY	Involvement of decreased glutamate receptor subunit GluR2 expression in lead-induced neuronal cell death .
7523595	0	glutamate	19,28	GluR2	47,52	glutamate	GluR2	CHEBI:29987	2891	Chemical	Gene	receptor|amod|START_ENTITY editing|nmod|receptor subunits|nsubj|editing subunits|dobj|END_ENTITY	RNA editing of the glutamate receptor subunits GluR2 and GluR6 in human brain tissue .
7537225	0	glutamate	77,86	GluR2	97,102	glutamate	GluR2	CHEBI:29987	2891	Chemical	Gene	receptors|compound|START_ENTITY binding|nmod|receptors END_ENTITY|amod|binding	The importance of two specific domains in ligand binding to the AMPA/kainate glutamate receptors GluR2 and GluR6 .
7715242	0	glutamate	57,66	GluR2	85,90	glutamate	GluR2	CHEBI:29987	29627(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY editing|nmod|receptor extent|nmod|editing differences|nmod|extent subunits|nsubj|differences subunits|dobj|END_ENTITY	Regional differences in the extent of RNA editing of the glutamate receptor subunits GluR2 and GluR6 in rat brain .
7937939	0	glutamate	43,52	GluR2	70,75	glutamate	GluR2	CHEBI:29987	2891	Chemical	Gene	sequence|amod|START_ENTITY sequence|compound|END_ENTITY	Intron sequence directs RNA editing of the glutamate receptor subunit GluR2 coding sequence .
8848293	0	glutamate	47,56	GluR2	70,75	glutamate	GluR2	CHEBI:29987	29627(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|nmod|Ser-696 Ser-696|amod|END_ENTITY	Antibody specific for phosphorylated AMPA-type glutamate receptors at GluR2 Ser-696 .
8964793	0	glutamate	15,24	GluR2	43,48	glutamate	GluR2	CHEBI:29987	29627(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY editing|nmod|receptor subunits|nsubj|editing subunits|dobj|END_ENTITY	RNA editing of glutamate receptor subunits GluR2 , GluR5 and GluR6 in transient cerebral_ischemia in the rat .
9030702	0	glutamate	6,15	GluR2	0,5	glutamate	GluR2	CHEBI:29987	2891	Chemical	Gene	flip|compound|START_ENTITY flip|amod|END_ENTITY	GluR2 glutamate receptor subunit flip and flop isoforms are decreased in the hippocampal formation in schizophrenia : a reverse transcriptase-polymerase chain reaction -LRB- RT-PCR -RRB- study .
9391042	0	glutamate	20,29	GluR2	40,45	glutamate	GluR2	CHEBI:29987	29627(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Overexpression of a glutamate receptor -LRB- GluR2 -RRB- ligand binding domain in Escherichia_coli : application of a novel protein folding screen .
16278146	0	glutamate	14,23	GluR3	44,49	glutamate	GluR3	CHEBI:29987	2892	Chemical	Gene	Antibodies|acl|START_ENTITY Antibodies|appos|END_ENTITY	Antibodies to glutamate receptor subtype 3 -LRB- GluR3 -RRB- are found in some patients suffering from epilepsy as the main disease , but not in patients whose epilepsy accompanies antiphospholipid_syndrome or Sneddon 's _ syndrome .
9111034	0	glutamate	37,46	GluR3	57,62	glutamate	GluR3	CHEBI:29987	2892	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Identification of amino_acids in the glutamate receptor , GluR3 , important for antibody-binding and receptor-specific activation .
11164787	0	glutamate	53,62	GluR5	81,86	glutamate	GluR5	CHEBI:29987	2897	Chemical	Gene	receptor|compound|START_ENTITY localization|nmod|receptor subunits|nsubj|localization subunits|dobj|END_ENTITY	Immunocytochemical localization of kainate-selective glutamate receptor subunits GluR5 , GluR6 , and GluR7 in the cat retina .
12672235	0	glutamate	149,158	GluR5	121,126	glutamate	GluR5	CHEBI:29987	29559(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY subtype|nmod|receptors subtype|amod|END_ENTITY	-LRB- S -RRB- -2 - Amino-3 - -LRB- 3-hydroxy-7 ,8 - dihydro-6H-cyclohepta -LSB- d -RSB- isoxazol-4-yl -RRB- propionic_acid , a potent and selective agonist at the GluR5 subtype of ionotropic glutamate receptors .
16837561	0	glutamate	93,102	GluR5	75,80	glutamate	GluR5	CHEBI:29987	29559(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|ionotropic ionotropic|appos|END_ENTITY	Antiallodynic and antihyperalgesic effects of selective competitive GLUK5 -LRB- GluR5 -RRB- ionotropic glutamate receptor antagonists in the capsaicin and carrageenan models in rats .
19588945	0	glutamate	4,13	GluR5	23,28	glutamate	GluR5	CHEBI:29987	2897	Chemical	Gene	agonist|amod|START_ENTITY agonist|compound|END_ENTITY	The glutamate receptor GluR5 agonist -LRB- S -RRB- -2 - amino-3 - -LRB- 3-hydroxy-7 ,8 - dihydro-6H-cyclohepta -LSB- d -RSB- isoxazol-4-yl -RRB- propionic_acid and the 8-methyl analogue : synthesis , molecular pharmacology , and biostructural characterization .
1977421	0	glutamate	19,28	GluR5	47,52	glutamate	GluR5	CHEBI:29987	100301967(Tax:8355)	Chemical	Gene	subunit|amod|START_ENTITY subunit|appos|END_ENTITY	Cloning of a novel glutamate receptor subunit , GluR5 : expression in the nervous system during development .
8260617	0	glutamate	41,50	GluR5	66,71	glutamate	GluR5	CHEBI:29987	2897	Chemical	Gene	genes|amod|START_ENTITY isoforms|nmod|genes isoforms|dep|END_ENTITY	Expression and novel subunit isoforms of glutamate receptor genes GluR5 and GluR6 .
8589992	0	glutamate	48,57	GluR5	73,78	glutamate	GluR5	CHEBI:29987	2897	Chemical	Gene	EAA3|amod|START_ENTITY EAA3|appos|END_ENTITY	cDNA cloning and functional properties of human glutamate receptor EAA3 -LRB- GluR5 -RRB- in homomeric and heteromeric configuration .
9051270	0	glutamate	40,49	GluR5	68,73	glutamate	GluR5	CHEBI:29987	29559(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY editing|nmod|receptor changes|nmod|editing subunits|nsubj|changes subunits|dobj|END_ENTITY	Developmental changes of RNA editing of glutamate receptor subunits GluR5 and GluR6 : in vivo versus in vitro .
17005866	0	glutamate	86,95	GluR6	113,118	glutamate	GluR6	CHEBI:29987	2898	Chemical	Gene	receptor|compound|START_ENTITY desensitization|nmod|receptor modulating|dobj|desensitization interactions|acl|modulating subunit|nsubj|interactions subunit|dobj|END_ENTITY	Interface interactions modulating desensitization of the kainate-selective ionotropic glutamate receptor subunit GluR6 .
19338341	0	glutamate	12,21	GluR6	22,27	glutamate	GluR6	CHEBI:29987	2898	Chemical	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Modeling of glutamate GluR6 receptor and its interactions with novel noncompetitive antagonists .
7528929	0	glutamate	50,59	GluR6	34,39	glutamate	GluR6	CHEBI:29987	2898	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Stable expression of a functional GluR6 homomeric glutamate receptor channel in mammalian cells .
7536611	0	glutamate	85,94	GluR6	78,83	glutamate	GluR6	CHEBI:29987	2898	Chemical	Gene	START_ENTITY|nsubj|expression expression|nmod|EAA4 EAA4|appos|END_ENTITY	Functional expression and pharmacological characterization of the human EAA4 -LRB- GluR6 -RRB- glutamate receptor : a kainate selective channel subunit .
8094892	0	glutamate	52,61	GluR6	46,51	glutamate	GluR6	CHEBI:29987	2898	Chemical	Gene	START_ENTITY|nsubj|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation and modulation of recombinant GluR6 glutamate receptors by cAMP-dependent protein kinase .
8163463	0	glutamate	30,39	GluR6	57,62	glutamate	GluR6	CHEBI:29987	2898	Chemical	Gene	receptor|amod|START_ENTITY topology|nmod|receptor subunit|nsubj|topology subunit|dobj|END_ENTITY	Transmembrane topology of the glutamate receptor subunit GluR6 .
8392189	2	glutamate	471,480	GluR6	442,447	glutamate	GluR6	CHEBI:29987	2898	Chemical	Gene	receptor|amod|START_ENTITY subtype|nmod|receptor subtype|amod|END_ENTITY	Loss of CA3 and hilar neurons was also induced by transducing organotypic hippocampal_slice_cultures with a replication-defective_herpes_simplex_virus -LRB- HSV -RRB- vector expressing the GluR6 kainate subtype of the glutamate receptor -LRB- HSVGluR6 -RRB- .
8889151	0	glutamate	28,37	GluR6	22,27	glutamate	GluR6	CHEBI:29987	54257(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Kinetics Kinetics|nmod|END_ENTITY	Kinetics of homomeric GluR6 glutamate receptor channels .
8942465	0	glutamate	42,51	GluR6	52,57	glutamate	GluR6	CHEBI:29987	2898	Chemical	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Lack of evidence for close linkage of the glutamate GluR6 receptor gene with schizophrenia .
9279810	0	glutamate	34,43	GluR6	28,33	glutamate	GluR6	CHEBI:29987	54257(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Permeation Permeation|nmod|END_ENTITY	Permeation and block of rat GluR6 glutamate receptor channels by internal and external polyamines .
9379408	0	glutamate	21,30	GluR6	15,20	glutamate	GluR6	CHEBI:29987	54257(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Control Control|nmod|END_ENTITY	Control of rat GluR6 glutamate receptor open probability by protein kinase A and calcineurin .
9596788	0	glutamate	65,74	GluR6	56,61	glutamate	GluR6	CHEBI:29987	54257(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|analysis analysis|nmod|block block|nmod|END_ENTITY	An analysis of philanthotoxin block for recombinant rat GluR6 -LRB- Q -RRB- glutamate receptor channels .
9694203	0	glutamate	54,63	GluR6	48,53	glutamate	GluR6	CHEBI:29987	2898	Chemical	Gene	subunits|compound|START_ENTITY subunits|compound|END_ENTITY	Editing status at the Q/R site of the GluR2 and GluR6 glutamate receptor subunits in the surgically excised hippocampus of patients with refractory_epilepsy .
19890003	0	glutamate	97,106	Glud1	25,30	glutamate	Glud1	CHEBI:29987	14661(Tax:10090)	Chemical	Gene	release|amod|START_ENTITY model|nmod|release expression|dep|model expression|nmod|END_ENTITY	Transgenic expression of Glud1 -LRB- glutamate_dehydrogenase_1 -RRB- in neurons : in vivo model of enhanced glutamate release , altered synaptic plasticity , and selective neuronal vulnerability .
21397652	0	glutamate	75,84	Glud1	9,14	glutamate	Glud1	CHEBI:29987	14661(Tax:10090)	Chemical	Gene	formation|amod|START_ENTITY increased|dobj|formation increased|nsubj|END_ENTITY	Neuronal Glud1 -LRB- glutamate_dehydrogenase_1 -RRB- over-expressing mice : increased glutamate formation and synaptic release , loss of synaptic activity , and adaptive changes in genomic expression .
21446915	0	glutamate	139,148	Glud1	125,130	glutamate	Glud1	D018698	14661(Tax:10090)	Chemical	Gene	release|amod|START_ENTITY gene|nmod|release gene|amod|END_ENTITY	Differential levels of glutamate_dehydrogenase_1 -LRB- GLUD1 -RRB- in Balb/c and C57BL/6 mice and the effects of overexpression of the Glud1 gene on glutamate release in striatum .
22924626	0	glutamate	84,93	Glud1	39,44	glutamate	Glud1	CHEBI:29987	14661(Tax:10090)	Chemical	Gene	handling|amod|START_ENTITY affects|dobj|handling affects|nsubj|Deletion Deletion|nmod|END_ENTITY	Deletion of glutamate_dehydrogenase_1 -LRB- Glud1 -RRB- in the central nervous system affects glutamate handling without altering synaptic transmission .
11264298	0	glutamate	17,26	Glur2	70,75	glutamate	Glur2	CHEBI:29987	14800(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY influence|nmod|expression influence|nmod|mice mice|amod|END_ENTITY	The influence of glutamate receptor 2 expression on excitotoxicity in Glur2 null mutant mice .
10364691	0	glutamate	31,40	GnRH	131,135	glutamate	GnRH	CHEBI:29987	25194(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY Characterization|nmod|receptors Characterization|nmod|neurons neurons|appos|END_ENTITY	Characterization of ionotropic glutamate receptors in rat hypothalamus , pituitary and immortalized gonadotropin-releasing_hormone -LRB- GnRH -RRB- neurons -LRB- GT1-7 cells -RRB- .
8973840	0	glutamate	72,81	GnRH	55,59	glutamate	GnRH	CHEBI:29987	25194(Tax:10116)	Chemical	Gene	release|xcomp|START_ENTITY release|nsubj|responses responses|appos|END_ENTITY	Different responses of gonadotropin-releasing_hormone -LRB- GnRH -RRB- release to glutamate receptor agonists during aging .
26296755	0	glutamate	34,43	Gria1	18,23	glutamate	Gria1	D018698	50592(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Low expression of Gria1 and Grin1 glutamate receptors in the nucleus accumbens of Spontaneously Hypertensive Rats -LRB- SHR -RRB- .
16964410	0	glutamate	124,133	Grm1	146,150	glutamate	Grm1	CHEBI:29987	2911	Chemical	Gene	receptor|compound|START_ENTITY mutation|nmod|receptor caused|nmod|mutation caused|dobj|1 1|appos|END_ENTITY	crv4 , a mouse model for human ataxia associated with kyphoscoliosis caused by an mRNA splicing mutation of the metabotropic glutamate receptor 1 -LRB- Grm1 -RRB- .
18435704	0	glutamate	37,46	Grm1	59,63	glutamate	Grm1	CHEBI:29987	14816(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|receptor receptor|appos|END_ENTITY	Oncogenic activities of metabotropic glutamate receptor 1 -LRB- Grm1 -RRB- in melanocyte transformation .
19843246	0	glutamate	44,53	Grm1	66,70	glutamate	Grm1	CHEBI:29987	14816(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	AKT2 is a downstream target of metabotropic glutamate receptor 1 -LRB- Grm1 -RRB- .
23085756	0	glutamate	13,22	Grm1	35,39	glutamate	Grm1	CHEBI:29987	14816(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Metabotropic glutamate receptor 1 -LRB- Grm1 -RRB- is an oncogene in epithelial cells .
26071318	0	glutamate	25,34	Grm3	47,51	glutamate	Grm3	D018698	108069(Tax:10090)	Chemical	Gene	START_ENTITY|xcomp|ameliorates_lupus-like_disease ameliorates_lupus-like_disease|nsubj|receptor receptor|appos|END_ENTITY	Ligation of metabotropic glutamate receptor 3 -LRB- Grm3 -RRB- ameliorates_lupus-like_disease by reducing B cells .
24390354	0	glutamate	104,113	Grm7	172,176	glutamate	Grm7	CHEBI:29987	108073(Tax:10090)	Chemical	Gene	level|compound|START_ENTITY variation|nmod|level BALB/cJ|dep|variation NMR|dep|BALB/cJ gene|nmod|NMR gene|nsubj|subtype subtype|appos|END_ENTITY	In vivo Proton NMR spectroscopy of genetic mouse models BALB/cJ and C57BL/6By : variation in hippocampal glutamate level and the metabotropic glutamate receptor , subtype 7 -LRB- Grm7 -RRB- gene .
21822733	0	glutamate	110,119	IGF-1	37,42	glutamate	IGF-1	CHEBI:29987	24482(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY Activation|acl|induced Activation|nmod|END_ENTITY	Activation of ERK1/2 and PI3K/Akt by IGF-1 on GAP-43 expression in DRG neurons with excitotoxicity induced by glutamate in vitro .
21291866	0	glutamate	18,27	Insulin	0,7	glutamate	Insulin	CHEBI:29987	3630	Chemical	Gene	GLT1|amod|START_ENTITY increases|dobj|GLT1 increases|nsubj|END_ENTITY	Insulin increases glutamate transporter GLT1 in cultured astrocytes .
9263201	0	glutamate	28,37	Interleukin-1_beta	0,18	glutamate	Interleukin-1 beta	CHEBI:29987	24494(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY inhibits|dobj|release inhibits|nsubj|END_ENTITY	Interleukin-1_beta inhibits glutamate release in hippocampus of young , but not aged , rats .
9577844	0	glutamate	71,80	Interleukin-1_beta	0,18	glutamate	Interleukin-1 beta	CHEBI:29987	24494(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY affect|dobj|release affect|nsubj|END_ENTITY	Interleukin-1_beta and interleukin-1 receptor antagonist do not affect glutamate release or calcium entry in rat striatal synaptosomes .
14511640	0	glutamate	42,51	KA2	70,73	glutamate	KA2	CHEBI:29987	2901	Chemical	Gene	subunit|amod|START_ENTITY subunit|appos|END_ENTITY	Trafficking and surface expression of the glutamate receptor subunit , KA2 .
21849545	0	glutamate	67,76	KCC2	124,128	glutamate	KCC2	CHEBI:29987	57138(Tax:10090)	Chemical	Gene	receptors|amod|START_ENTITY END_ENTITY|nmod|receptors	Determination of transmembrane water fluxes in neurons elicited by glutamate ionotropic receptors and by the cotransporters KCC2 and NKCC1 : a digital holographic microscopy study .
23859404	0	glutamate	52,61	MEK1/2	21,27	glutamate	MEK1/2	CHEBI:29987	5604;5605	Chemical	Gene	toxicity|compound|START_ENTITY END_ENTITY|nmod|toxicity	PI3Ky contributes to MEK1/2 activation in oxidative glutamate toxicity via PDK1 .
10967307	0	glutamate	63,72	MGluR5	83,89	glutamate	MGluR5	CHEBI:29987	24418(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Synaptic relationship of the neurons containing a metabotropic glutamate receptor , MGluR5 , with nociceptive primary afferent and GABAergic terminals in rat spinal superficial laminae .
8784139	0	glutamate	46,55	MS-153	21,27	glutamate	MS-153	CHEBI:29987	3207684(Tax:155537)	Chemical	Gene	level|compound|START_ENTITY END_ENTITY|nmod|level	Inhibitory effect of MS-153 on elevated brain glutamate level induced by rat middle cerebral artery_occlusion .
16987251	0	glutamate	42,51	MacMARCKS	0,9	glutamate	MacMARCKS	CHEBI:29987	65108	Chemical	Gene	receptor|compound|START_ENTITY interacts|nmod|receptor interacts|nsubj|END_ENTITY	MacMARCKS interacts with the metabotropic glutamate receptor type 7 and modulates G protein-mediated constitutive inhibition of calcium channels .
10630204	0	glutamate	16,25	NMDAR1	43,49	glutamate	NMDAR1	CHEBI:29987	2902	Chemical	Gene	receptor|amod|START_ENTITY Distribution|nmod|receptor subunit|nsubj|Distribution subunit|dobj|END_ENTITY	Distribution of glutamate receptor subunit NMDAR1 in the hippocampus of normal elderly and patients with Alzheimer 's _ disease .
10762714	0	glutamate	35,44	NMDAR1	28,34	glutamate	NMDAR1	CHEBI:29987	2902	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Alternative splicing of the NMDAR1 glutamate receptor subunit in human temporal_lobe_epilepsy .
11391705	0	glutamate	105,114	NMDAR1	98,104	glutamate	NMDAR1	CHEBI:29987	24408(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY receptor|nummod|END_ENTITY	Nitric_oxide synthase-positive neurons in the rat superior colliculus : colocalization of NOS with NMDAR1 glutamate receptor , GABA , and parvalbumin .
11562137	0	glutamate	120,129	NMDAR1	130,136	glutamate	NMDAR1	CHEBI:29987	2902	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	In vivo microdialysis and immunohistochemical analyses of tendon tissue demonstrated high amounts of free glutamate and glutamate NMDAR1 receptors , but no signs of inflammation , in Jumper 's _ knee .
11588613	0	glutamate	46,55	NMDAR1	39,45	glutamate	NMDAR1	CHEBI:29987	2902	Chemical	Gene	START_ENTITY|nsubj|reductions reductions|nmod|END_ENTITY	Asymmetrical reductions of hippocampal NMDAR1 glutamate receptor mRNA in the psychoses .
1322972	0	glutamate	38,47	NMDAR1	31,37	glutamate	NMDAR1	CHEBI:29987	24408(Tax:10116)	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	Immunological detection of the NMDAR1 glutamate receptor subunit expressed in embryonic kidney 293 cells and in rat brain .
8515871	0	glutamate	45,54	NMDAR1	38,44	glutamate	NMDAR1	CHEBI:29987	24408(Tax:10116)	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	Alternatively spliced isoforms of the NMDAR1 glutamate receptor subunit : differential expression in the basal ganglia of the rat .
8576429	0	glutamate	55,64	NMDAR1	48,54	glutamate	NMDAR1	CHEBI:29987	24408(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Comparative ultrastructural localization of the NMDAR1 glutamate receptor in the rat basolateral amygdala and bed nucleus of the stria terminalis .
8613793	0	glutamate	70,79	NMDAR1	63,69	glutamate	NMDAR1	CHEBI:29987	24408(Tax:10116)	Chemical	Gene	subunits|amod|START_ENTITY subunits|nummod|END_ENTITY	Drugs of abuse and stress increase the expression of GluR1 and NMDAR1 glutamate receptor subunits in the rat ventral tegmental area : common adaptations among cross-sensitizing agents .
8773773	0	glutamate	74,83	NMDAR1	84,90	glutamate	NMDAR1	CHEBI:29987	24408(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Transiently catecholaminergic cells in the fetal rat express mRNA for the glutamate NMDAR1 receptor .
8981427	0	glutamate	32,41	NMDAR1	61,67	glutamate	NMDAR1	CHEBI:29987	24408(Tax:10116)	Chemical	Gene	subunits|amod|START_ENTITY subunits|dep|END_ENTITY	Ultrastructural localization of glutamate receptor subunits -LRB- NMDAR1 , AMPA GluR1 and GluR2/3 -RRB- and spinothalamic tract cells .
9672385	0	glutamate	41,50	NMDAR1	34,40	glutamate	NMDAR1	CHEBI:29987	2902	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	N-terminal splice variants of the NMDAR1 glutamate receptor subunit : differential expression in human and monkey brain .
9832144	0	glutamate	44,53	NMDAR1	14,20	glutamate	NMDAR1	CHEBI:29987	2902	Chemical	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of NMDAR1 , GluR1 , GluR7 , and KA1 glutamate receptor mRNAs is decreased in frontal cortex of `` neuroleptic-free '' schizophrenics : evidence on reversible up-regulation by typical neuroleptics .
9878792	0	glutamate	14,23	NMDAR1	68,74	glutamate	NMDAR1	CHEBI:29987	2902	Chemical	Gene	receptor|amod|START_ENTITY Expression|nmod|receptor subunit/subtype|nsubj|Expression subunit/subtype|nmod|END_ENTITY	Expression of glutamate receptor subunit/subtype messenger RNAS for NMDAR1 , GLuR1 , GLuR2 and mGLuR5 by accumbal projection neurons .
8915584	0	glutamate	22,31	NMDAR2D	14,21	glutamate	NMDAR2D	CHEBI:29987	24412(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of NMDAR2D glutamate receptor subunit mRNA in neurochemically identified interneurons in the rat neostriatum , neocortex and hippocampus .
11545720	2	glutamate	416,425	NMR-1	363,368	glutamate	nmr-1	CHEBI:29987	173929(Tax:6239)	Chemical	Gene	subunit|amod|START_ENTITY END_ENTITY|appos|subunit	We have used genetic and electrophysiological methods to demonstrate that NMR-1 , a Caenorhabditis_elegans NMDA-type ionotropic glutamate receptor subunit , plays a role in the control of movement and foraging behavior .
18640148	0	glutamate	124,133	NR1	120,123	glutamate	NR1	CHEBI:29987	24408(Tax:10116)	Chemical	Gene	subunits|amod|START_ENTITY subunits|nummod|END_ENTITY	Cocaine-induced behavioral sensitization in adolescent rats endures until adulthood : lack of association with GluR1 and NR1 glutamate receptor subunits and tyrosine hydroxylase .
20667449	0	glutamate	13,22	NR1	95,98	glutamate	NR1	CHEBI:29987	24408(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Metabotropic glutamate mGlu5 receptor-mediated serine phosphorylation of NMDA receptor subunit NR1 in hippocampal CA1 region after transient global ischemia in rats .
15928921	0	glutamate	140,149	NR2A	75,79	glutamate	NR2A	CHEBI:29987	2903	Chemical	Gene	receptor|amod|START_ENTITY subunits|nmod|receptor subunits|compound|END_ENTITY	Comparative analysis of different competitive antagonists interaction with NR2A and NR2B subunits of N-methyl-D-aspartate -LRB- NMDA -RRB- ionotropic glutamate receptor .
11841566	0	glutamate	27,36	NR2B	149,153	glutamate	NR2B	CHEBI:29987	24410(Tax:10116)	Chemical	Gene	excitotoxicity|amod|START_ENTITY protection|nmod|excitotoxicity protection|dep|involvement involvement|acl|inhibition inhibition|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Lithium protection against glutamate excitotoxicity in rat cerebral cortical neurons : involvement of NMDA receptor inhibition possibly by decreasing NR2B tyrosine phosphorylation .
16500747	0	glutamate	113,122	NR2B	108,112	glutamate	NR2B	CHEBI:29987	24410(Tax:10116)	Chemical	Gene	subunits|amod|START_ENTITY subunits|nummod|END_ENTITY	Dietary enrichment with omega-3_polyunsaturated_fatty_acids reverses age-related decreases in the GluR2 and NR2B glutamate receptor subunits in rat forebrain .
19335206	0	glutamate	59,68	NR2B	54,58	glutamate	NR2B	CHEBI:29987	24410(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	A novel protein complex in membrane rafts linking the NR2B glutamate receptor and autophagy is disrupted following traumatic_brain_injury .
26671102	0	glutamate	50,59	NR2B	45,49	glutamate	NR2B	D018698	14812(Tax:10090)	Chemical	Gene	subunit|amod|START_ENTITY subunit|compound|END_ENTITY	Experimental evidence that overexpression of NR2B glutamate receptor subunit is associated with brain vacuolation in adult glutaryl-CoA dehydrogenase deficient mice : A potential role for glutamatergic-induced excitotoxicity in GA_I neuropathology .
9115742	0	glutamate	92,101	NR2B	122,126	glutamate	NR2B	CHEBI:29987	2904	Chemical	Gene	site|amod|START_ENTITY site|nmod|subunit subunit|compound|END_ENTITY	Molecular determinants of agonist discrimination by NMDA receptor subunits : analysis of the glutamate binding site on the NR2B subunit .
9795172	0	glutamate	55,64	NR2B	90,94	glutamate	NR2B	CHEBI:29987	24410(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY electroconvulsive_shock|nmod|receptor effects|nmod|electroconvulsive_shock mRNAs|nsubj|effects mRNAs|nmod|NR2A NR2A|nummod|END_ENTITY	Differential effects of electroconvulsive_shock on the glutamate receptor mRNAs for NR2A , NR2B and mGluR5b .
10521569	0	glutamate	49,58	Neurokinin-1	0,12	glutamate	Neurokinin-1	CHEBI:29987	6863	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Neurokinin-1 expression and co-localization with glutamate and GABA in the hypothalamus of the cat .
10320715	0	glutamate	24,33	Neuropeptide_Y	0,14	glutamate	Neuropeptide Y	CHEBI:29987	24604(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY inhibits|dobj|release inhibits|nsubj|END_ENTITY	Neuropeptide_Y inhibits glutamate release and long-term potentiation in rat dentate gyrus .
7858862	0	glutamate	45,54	Neuropeptide_Y	0,14	glutamate	Neuropeptide Y	CHEBI:29987	24604(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY inhibits|dobj|release inhibits|nsubj|END_ENTITY	Neuropeptide_Y inhibits potassium-stimulated glutamate release through Y2 receptors in rat hippocampal slices in vitro .
21985178	0	glutamate	26,35	Nogo-A	9,15	glutamate	Nogo-A	CHEBI:29987	57142	Chemical	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Neuronal Nogo-A regulates glutamate receptor subunit expression in hippocampal neurons .
15326176	0	glutamate	75,84	P-glycoprotein	14,28	glutamate	P-glycoprotein	CHEBI:29987	67078(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Properties Properties|nmod|END_ENTITY	Properties of P-glycoprotein with mutations in the `` catalytic carboxylate '' glutamate residues .
8280165	0	glutamate	25,34	P19	53,56	glutamate	P19	CHEBI:29987	12581(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Expression of ionotropic glutamate receptor genes by P19 embryonal_carcinoma cells .
16000618	0	glutamate	35,44	P2X1	70,74	glutamate	P2X1	CHEBI:29987	25505(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	Dual presynaptic control by ATP of glutamate release via facilitatory P2X1 , P2X2/3 , and P2X3 and inhibitory P2Y1 , P2Y2 , and/or P2Y4 receptors in the rat hippocampus .
24506432	0	glutamate	21,30	PKC_gamma	63,72	glutamate	PKC gamma	CHEBI:29987	24681(Tax:10116)	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Group I metabotropic glutamate receptor-mediated activation of PKC_gamma in the nucleus accumbens core promotes the reinstatement of cocaine seeking .
17506933	0	glutamate	58,67	PSD-95	15,21	glutamate	PSD-95	CHEBI:29987	1742	Chemical	Gene	START_ENTITY|nsubj|Requirement Requirement|nmod|END_ENTITY	Requirement of PSD-95 for dopamine_D1_receptor modulating glutamate NR1a/NR2B receptor function .
16144832	0	glutamate	50,59	Pias1	0,5	glutamate	Pias1	CHEBI:29987	8554	Chemical	Gene	interaction|nmod|START_ENTITY interaction|amod|END_ENTITY	Pias1 interaction and sumoylation of metabotropic glutamate receptor 8 .
25890014	0	glutamate	8,17	Pika	101,105	glutamate	Pika	D018698	133584	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|response response|nmod|END_ENTITY	Role of glutamate and serotonin on the hypoxic ventilatory response in high-altitude-adapted plateau Pika .
19020017	0	glutamate	32,41	RANTES	0,6	glutamate	RANTES	CHEBI:29987	6352	Chemical	Gene	release|nmod|START_ENTITY modulates|dobj|release modulates|nsubj|END_ENTITY	RANTES modulates the release of glutamate in human neocortex .
18499195	0	glutamate	39,48	RIM1alpha	12,21	glutamate	RIM1alpha	CHEBI:29987	116837(Tax:10090)	Chemical	Gene	release|compound|START_ENTITY role|nmod|release role|nmod|END_ENTITY	The role of RIM1alpha in BDNF-enhanced glutamate release .
16794859	0	glutamate	5,14	S100B	25,30	glutamate	S100B	CHEBI:29987	6285	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|secretion secretion|compound|END_ENTITY	High glutamate decreases S100B secretion by a mechanism dependent on the glutamate transporter .
15504348	0	glutamate	25,34	SGK	50,53	glutamate	SGK	CHEBI:29987	399130(Tax:8355)	Chemical	Gene	START_ENTITY|nmod|isoforms isoforms|compound|END_ENTITY	Stimulation of the EAAT4 glutamate transporter by SGK protein kinase isoforms and PKB .
17221839	0	glutamate	42,51	SLC1A1	70,76	glutamate	SLC1A1	CHEBI:29987	6505	Chemical	Gene	transporter|amod|START_ENTITY polymorphisms|nmod|transporter study|nmod|polymorphisms genes|nsubj|study genes|dobj|END_ENTITY	Association study of polymorphisms in the glutamate transporter genes SLC1A1 , SLC1A3 , and SLC1A6 with schizophrenia .
17894418	0	glutamate	26,35	SLC1A1	19,25	glutamate	SLC1A1	CHEBI:29987	6505	Chemical	Gene	START_ENTITY|nsubj|Association Association|nmod|END_ENTITY	Association of the SLC1A1 glutamate transporter gene and obsessive-compulsive_disorder .
19152386	0	glutamate	40,49	SLC1A1	67,73	glutamate	SLC1A1	CHEBI:29987	6505	Chemical	Gene	gene|amod|START_ENTITY study|nmod|gene END_ENTITY|nsubj|study	A family-based association study of the glutamate transporter gene SLC1A1 in obsessive-compulsive_disorder in 378 families .
19884611	0	glutamate	19,28	SLC1A1	46,52	glutamate	SLC1A1	CHEBI:29987	6505	Chemical	Gene	gene|amod|START_ENTITY Association|nmod|gene END_ENTITY|nsubj|Association	Association of the glutamate transporter gene SLC1A1 with atypical antipsychotics-induced obsessive-compulsive_symptoms .
22424243	0	glutamate	19,28	SLC1A1	42,48	glutamate	SLC1A1	CHEBI:29987	6505	Chemical	Gene	expression|nmod|START_ENTITY transporters|nsubj|expression transporters|dobj|END_ENTITY	Gene expression of glutamate transporters SLC1A1 , SLC1A3 and SLC1A6 in the cerebellar subregions of elderly schizophrenia patients and effects of antipsychotic treatment .
23341099	0	glutamate	23,32	SLC1A1	16,22	glutamate	SLC1A1	CHEBI:29987	6505	Chemical	Gene	START_ENTITY|nsubj|Deletion Deletion|nmod|END_ENTITY	Deletion at the SLC1A1 glutamate transporter gene co-segregates with schizophrenia and bipolar_schizoaffective_disorder in a 5-generation family .
16427633	0	glutamate	27,36	SynGAP	60,66	glutamate	SynGAP	CHEBI:29987	8831	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Differential mechanisms of glutamate receptor regulation of SynGAP in cortical neurones .
1345942	0	glutamate	21,30	Synapsin_I	0,10	glutamate	Synapsin I	CHEBI:29987	24949(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY regulates|dobj|release regulates|nsubj|END_ENTITY	Synapsin_I regulates glutamate release from rat brain synaptosomes .
15197251	0	glutamate	33,42	Synaptotagmin_IV	0,16	glutamate	Synaptotagmin IV	CHEBI:29987	6860	Chemical	Gene	release|compound|START_ENTITY regulates|dobj|release regulates|nsubj|END_ENTITY	Synaptotagmin_IV regulates glial glutamate release .
23536313	0	glutamate	9,18	TGF-b1	91,97	glutamate	TGF-b1	CHEBI:29987	21803(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|acl|lacking lacking|dobj|END_ENTITY	Impaired glutamate recycling and GluN2B-mediated neuronal calcium overload in mice lacking TGF-b1 in the CNS .
11426226	0	glutamate	26,35	TNFalpha	48,56	glutamate	TNFalpha	CHEBI:29987	7124	Chemical	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	CXCR4-activated astrocyte glutamate release via TNFalpha : amplification by microglia triggers neurotoxicity .
16055093	0	glutamate	73,82	Thyrotropin-releasing_hormone	0,29	glutamate	Thyrotropin-releasing hormone	CHEBI:29987	25569(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY inhibits|dobj|release inhibits|nsubj|END_ENTITY	Thyrotropin-releasing_hormone -LRB- protirelin -RRB- inhibits potassium-stimulated glutamate and aspartate release from hippocampal slices in vitro .
16720574	0	glutamate	54,63	Tumor_necrosis_factor-alpha	0,27	glutamate	Tumor necrosis factor-alpha	CHEBI:29987	7124	Chemical	Gene	release|amod|START_ENTITY neurotoxicity|nmod|release induces|dobj|neurotoxicity induces|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner .
19368827	0	glutamate	38,47	Tumor_necrosis_factor-alpha	0,27	glutamate	Tumor necrosis factor-alpha	CHEBI:29987	21926(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|modulates modulates|amod|END_ENTITY	Tumor_necrosis_factor-alpha modulates glutamate transport in the CNS and is a critical determinant of outcome from viral encephalomyelitis .
7705222	0	glutamate	40,49	Tumor_necrosis_factor-alpha	0,27	glutamate	Tumor necrosis factor-alpha	CHEBI:29987	7124	Chemical	Gene	START_ENTITY|nsubj|potentiates potentiates|amod|END_ENTITY	Tumor_necrosis_factor-alpha potentiates glutamate neurotoxicity in human fetal brain cell cultures .
12559000	0	glutamate	27,36	VGLUT1	51,57	glutamate	VGLUT1	CHEBI:29987	116638(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|transporters transporters|appos|END_ENTITY	Co-expression of vesicular glutamate transporters -LRB- VGLUT1 and VGLUT2 -RRB- and their association with synaptic-like microvesicles in rat pinealocytes .
12975818	0	glutamate	59,68	VGLUT1	82,88	glutamate	VGLUT1	CHEBI:29987	57030	Chemical	Gene	transporters|nsubj|START_ENTITY transporters|dobj|END_ENTITY	Hypothalamic orexin -LRB- hypocretin -RRB- neurons express vesicular glutamate transporters VGLUT1 or VGLUT2 .
14614902	0	glutamate	10,19	VGLUT1	33,39	glutamate	VGLUT1	CHEBI:29987	72961(Tax:10090)	Chemical	Gene	START_ENTITY|ccomp|define define|nsubj|END_ENTITY	Vesicular glutamate transporters VGLUT1 and VGLUT2 define two subsets of unipolar brush cells in organotypic cultures of mouse vestibulocerebellum .
14706788	0	glutamate	73,82	VGLUT1	96,102	glutamate	VGLUT1	CHEBI:29987	116638(Tax:10116)	Chemical	Gene	subunit|nmod|START_ENTITY co-localisation|nmod|subunit transporters|nsubj|co-localisation transporters|dobj|END_ENTITY	Differential co-localisation of the P2X7 receptor subunit with vesicular glutamate transporters VGLUT1 and VGLUT2 in rat CNS .
15192755	0	glutamate	53,62	VGLUT1	75,81	glutamate	VGLUT1	CHEBI:29987	116638(Tax:10116)	Chemical	Gene	START_ENTITY|dep|using using|nsubj|END_ENTITY	Expression and purification of recombinant vesicular glutamate transporter VGLUT1 using PC12 cells and High Five insect cells .
15379996	0	glutamate	24,33	VGLUT1	48,54	glutamate	VGLUT1	CHEBI:29987	57030	Chemical	Gene	START_ENTITY|dobj|transporters transporters|appos|END_ENTITY	Expression of vesicular glutamate transporters , VGLUT1 and VGLUT2 , in cholinergic spinal motoneurons .
15992385	0	glutamate	51,60	VGLUT1	74,80	glutamate	VGLUT1	CHEBI:29987	116638(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|transporter transporter|appos|END_ENTITY	Evidence for increased expression of the vesicular glutamate transporter , VGLUT1 , by a course of antidepressant treatment .
16563567	0	glutamate	32,41	VGLUT1	55,61	glutamate	VGLUT1	CHEBI:29987	57030	Chemical	Gene	expression|nmod|START_ENTITY transporters|nsubj|expression transporters|dobj|END_ENTITY	Altered expression of vesicular glutamate transporters VGLUT1 and VGLUT2 in Parkinson_disease .
16710756	0	glutamate	171,180	VGLUT1	72,78	glutamate	VGLUT1	CHEBI:29987	116638(Tax:10116)	Chemical	Gene	trafficking|compound|START_ENTITY implications|nmod|trafficking Identification|dep|implications Identification|nmod|partners partners|nmod|END_ENTITY	Identification of endophilins_1_and_3 as selective binding partners for VGLUT1 and their co-localization in neocortical glutamatergic synapses : implications for vesicular glutamate transporter trafficking and excitatory vesicle formation .
16942593	0	glutamate	46,55	VGLUT1	69,75	glutamate	VGLUT1	CHEBI:29987	72961(Tax:10090)	Chemical	Gene	co-localization|nmod|START_ENTITY transporters|nsubj|co-localization transporters|dobj|END_ENTITY	Synaptic and vesicular co-localization of the glutamate transporters VGLUT1 and VGLUT2 in the mouse hippocampus .
17289331	0	glutamate	10,19	VGLUT1	33,39	glutamate	VGLUT1	CHEBI:29987	72961(Tax:10090)	Chemical	Gene	transporters|nsubj|START_ENTITY transporters|dobj|END_ENTITY	Vesicular glutamate transporters VGLUT1 and VGLUT2 in the developing mouse barrel cortex .
19169251	0	glutamate	51,60	VGLUT1	26,32	glutamate	VGLUT1	CHEBI:29987	57030	Chemical	Gene	loading|compound|START_ENTITY underlies|dobj|loading underlies|nsubj|conductance conductance|nmod|END_ENTITY	A chloride conductance in VGLUT1 underlies maximal glutamate loading into synaptic vesicles .
19720501	0	glutamate	48,57	VGLUT1	78,84	glutamate	VGLUT1	CHEBI:29987	57030	Chemical	Gene	START_ENTITY|dobj|gene gene|appos|END_ENTITY	Resequencing and association study of vesicular glutamate transporter 1 gene -LRB- VGLUT1 -RRB- with schizophrenia .
20632124	0	glutamate	16,25	VGLUT1	49,55	glutamate	VGLUT1	CHEBI:29987	116638(Tax:10116)	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Coexpression of glutamate vesicular transporter -LRB- VGLUT1 -RRB- and choline acetyltransferase -LRB- ChAT -RRB- proteins in fetal rat hippocampal neurons in culture .
23168115	0	glutamate	62,71	VGLUT1	45,51	glutamate	VGLUT1	CHEBI:29987	72961(Tax:10090)	Chemical	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Regulation of serotonin -LRB- 5-HT -RRB- function by a VGLUT1 dependent glutamate pathway .
25749864	0	glutamate	42,51	VGLUT1	17,23	glutamate	VGLUT1	D018698	116638(Tax:10116)	Chemical	Gene	co-release|compound|START_ENTITY sustains|dobj|co-release sustains|nsubj|Co-expression Co-expression|nmod|END_ENTITY	Co-expression of VGLUT1 and VGAT sustains glutamate and GABA co-release and is regulated by activity in cortical neurons .
11698620	0	glutamate	104,113	VGLUT2	127,133	glutamate	VGLUT2	CHEBI:29987	57084	Chemical	Gene	START_ENTITY|dobj|transporter transporter|appos|END_ENTITY	Identification of differentiation-associated brain-specific phosphate transporter as a second vesicular glutamate transporter -LRB- VGLUT2 -RRB- .
14697503	0	glutamate	10,19	VGLUT2	82,88	glutamate	VGLUT2	CHEBI:29987	84487(Tax:10116)	Chemical	Gene	transporters|compound|START_ENTITY transporters|dep|expression expression|nmod|END_ENTITY	Vesicular glutamate transporters in the lateral geniculate nucleus : expression of VGLUT2 by retinal terminals .
15009640	0	glutamate	80,89	VGLUT2	36,42	glutamate	VGLUT2	CHEBI:29987	84487(Tax:10116)	Chemical	Gene	release|dobj|START_ENTITY capacity|acl|release explaining|dobj|capacity explaining|nsubj|END_ENTITY	Dopamine neurons in culture express VGLUT2 explaining their capacity to release glutamate at synapses in addition to dopamine .
17108179	0	glutamate	10,19	VGLUT2	32,38	glutamate	VGLUT2	CHEBI:29987	140919(Tax:10090)	Chemical	Gene	levels|compound|START_ENTITY levels|nummod|END_ENTITY	Vesicular glutamate transporter VGLUT2 expression levels control quantal size and neuropathic_pain .
18381590	0	glutamate	78,87	VGLUT2	103,109	glutamate	VGLUT2	CHEBI:29987	84487(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|2 2|appos|END_ENTITY	Coexpression of the mu-opioid receptor splice variant MOR1C and the vesicular glutamate transporter 2 -LRB- VGLUT2 -RRB- in rat central nervous system .
20541370	0	glutamate	30,39	VGLUT2	60,66	glutamate	VGLUT2	CHEBI:29987	57084	Chemical	Gene	transporter|compound|START_ENTITY Resequencing|nmod|transporter reveals|dep|Resequencing reveals|nsubj|gene gene|appos|END_ENTITY	Resequencing of the vesicular glutamate transporter 2 gene -LRB- VGLUT2 -RRB- reveals some rare genetic variants that may increase the genetic burden in schizophrenia .
14751290	0	glutamate	38,47	VGLUT3	16,22	glutamate	VGLUT3	CHEBI:29987	266767(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|appos|transporter	Localization of VGLUT3 , the vesicular glutamate transporter type 3 , in the rat brain .
18278042	0	glutamate	14,23	VGLUT3	36,42	glutamate	VGLUT3	CHEBI:29987	216227(Tax:10090)	Chemical	Gene	START_ENTITY|ccomp|synergizes synergizes|nsubj|END_ENTITY	The vesicular glutamate transporter VGLUT3 synergizes striatal acetylcholine tone .
19467322	0	glutamate	24,33	VGLUT3	139,145	glutamate	VGLUT3	CHEBI:29987	246213	Chemical	Gene	neurons|compound|START_ENTITY contain|nsubj|neurons contain|dobj|vesicular_glutamate_transporter_3 vesicular_glutamate_transporter_3|appos|END_ENTITY	Locally collateralizing glutamate neurons in the dorsal raphe nucleus responsive to substance_P contain vesicular_glutamate_transporter_3 -LRB- VGLUT3 -RRB- .
21177991	0	glutamate	66,75	VGLUT3	34,40	glutamate	VGLUT3	CHEBI:29987	216227(Tax:10090)	Chemical	Gene	release|nmod|START_ENTITY END_ENTITY|nmod|release	Role of the vesicular transporter VGLUT3 in retrograde release of glutamate by cerebellar Purkinje cells .
22890712	0	glutamate	14,23	VGLUT3	36,42	glutamate	VGLUT3	D018698	216227(Tax:10090)	Chemical	Gene	START_ENTITY|ccomp|contributes contributes|nsubj|END_ENTITY	The vesicular glutamate transporter VGLUT3 contributes to protection against neonatal hypoxic stress .
26441632	0	glutamate	14,23	VGLUT3	98,104	glutamate	VGLUT3	D018698	246213	Chemical	Gene	Co-release|nmod|START_ENTITY neurons|nsubj|Co-release neurons|xcomp|expressing expressing|dobj|END_ENTITY	Co-release of glutamate and GABA from single vesicles in GABAergic neurons exogenously expressing VGLUT3 .
24639017	0	glutamate	92,101	VGluT1	124,130	glutamate	VGluT1	CHEBI:29987	57030	Chemical	Gene	isoforms|compound|START_ENTITY isoforms|appos|END_ENTITY	A subset of thalamocortical projections to the retrosplenial cortex possesses two vesicular glutamate transporter isoforms , VGluT1 and VGluT2 , in axon terminals and somata .
26113146	0	glutamate	88,97	VGluT1	111,117	glutamate	VGluT1	D018698	72961(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	The initial stage of reversal learning is impaired in mice hemizygous for the vesicular glutamate transporter -LRB- VGluT1 -RRB- .
18050306	0	glutamate	81,90	VGluT2	0,6	glutamate	VGluT2	CHEBI:29987	57084	Chemical	Gene	release|compound|START_ENTITY evidence|nmod|release expression|dep|evidence expression|amod|END_ENTITY	VGluT2 expression in painful Achilles_and_patellar_tendinosis : evidence of local glutamate release by tenocytes .
19446630	0	glutamate	51,60	VGluT2	74,80	glutamate	VGluT2	CHEBI:29987	57084	Chemical	Gene	START_ENTITY|dobj|transporter transporter|appos|END_ENTITY	Regional and laminar distribution of the vesicular glutamate transporter , VGluT2 , in the macaque monkey auditory cortex .
21484883	0	glutamate	17,26	VGlut2	102,108	glutamate	VGlut2	CHEBI:29987	84487(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY antagonist|nsubj|receptor antagonist|parataxis|pyridine pyridine|dep|decreases decreases|dobj|expression expression|amod|END_ENTITY	The metabotropic glutamate receptor antagonist 2-methyl-6 - -LRB- phenylethynyl -RRB- _ pyridine decreases striatal VGlut2 expression in association with an attenuation of L-DOPA-induced dyskinesias .
16763021	0	glutamate	21,30	Vasopressin	0,11	glutamate	Vasopressin	CHEBI:29987	551	Chemical	Gene	release|amod|START_ENTITY inhibits|dobj|release inhibits|nsubj|END_ENTITY	Vasopressin inhibits glutamate release via two distinct modes in the brainstem .
17689254	0	glutamate	36,45	alpha-synuclein	8,23	glutamate	alpha-synuclein	CHEBI:29987	6622	Chemical	Gene	release|compound|START_ENTITY Role|nmod|release Role|nmod|END_ENTITY	Role of alpha-synuclein in synaptic glutamate release .
17462791	0	glutamate	50,59	alpha7_nicotinic_receptor	14,39	glutamate	alpha7 nicotinic receptor	CHEBI:29987	11441(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|modulates modulates|amod|END_ENTITY	Evidence that alpha7_nicotinic_receptor modulates glutamate release from mouse neocortical gliosomes .
10374630	0	glutamate	39,48	beta-endorphin	21,35	glutamate	beta-endorphin	CHEBI:29987	5443	Chemical	Gene	neurotoxicity|amod|START_ENTITY END_ENTITY|nmod|neurotoxicity	Enhancing effects of beta-endorphin on glutamate neurotoxicity .
12946709	0	glutamate	87,96	c-Fos	10,15	glutamate	c-Fos	CHEBI:29987	14281(Tax:10090)	Chemical	Gene	mice|amod|START_ENTITY thalamus|nmod|mice nucleus|nmod|thalamus expression|nmod|nucleus expression|amod|END_ENTITY	Increased c-Fos expression in the centromedial nucleus of the thalamus in metabotropic glutamate 8 receptor knockout mice following the elevated plus maze test .
16075465	0	glutamate	25,34	c-Fos	8,13	glutamate	c-Fos	CHEBI:29987	2353	Chemical	Gene	toxicity|amod|START_ENTITY Role|nmod|toxicity Role|nmod|protein protein|amod|END_ENTITY	Role of c-Fos protein on glutamate toxicity in primary neural hippocampal cells .
17304580	0	glutamate	27,36	c-Fos	144,149	glutamate	c-Fos	CHEBI:29987	314322(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY associated|nsubj|receptors associated|parataxis|inhibits inhibits|dobj|expression expression|amod|END_ENTITY	Glutamate and metabotropic glutamate receptors associated with innervation of the uterine cervix during pregnancy : receptor antagonism inhibits c-Fos expression in rat lumbosacral spinal cord at parturition .
20963566	0	glutamate	46,55	c-Fos	79,84	glutamate	c-Fos	CHEBI:29987	2353	Chemical	Gene	receptors|compound|START_ENTITY receptors|acl|evidenced evidenced|nmod|immunohistochemistry immunohistochemistry|amod|END_ENTITY	Activation of orexin neurons through non-NMDA glutamate receptors evidenced by c-Fos immunohistochemistry .
12558976	0	glutamate	107,116	c-Jun_N-terminal_kinase	14,37	glutamate	c-Jun N-terminal kinase	CHEBI:29987	116554(Tax:10116)	Chemical	Gene	excitotoxicity|amod|START_ENTITY roles|nmod|excitotoxicity Regulation|dep|roles Regulation|nmod|kinase kinase|amod|END_ENTITY	Regulation of c-Jun_N-terminal_kinase , p38 kinase and AP-1 DNA binding in cultured brain neurons : roles in glutamate excitotoxicity and lithium neuroprotection .
15056716	0	glutamate	270,279	c-Jun_N-terminal_kinase	153,176	glutamate	c-Jun N-terminal kinase	CHEBI:29987	5599	Chemical	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun_N-terminal_kinase , cyclin-dependent_kinase_5 , and p38 mitogen-activated protein kinase as well as metabotropic glutamate receptor type 5 .
16421317	0	glutamate	66,75	c-Jun_N-terminal_kinase	118,141	glutamate	c-Jun N-terminal kinase	CHEBI:29987	5599	Chemical	Gene	receptors|compound|START_ENTITY mechanism|nmod|receptors mechanism|dep|role role|nmod|pathway pathway|amod|END_ENTITY	A signaling mechanism from G alpha q-protein-coupled metabotropic glutamate receptors to gene expression : role of the c-Jun_N-terminal_kinase pathway .
10401552	0	glutamate	9,18	c-fos	56,61	glutamate	c-fos	CHEBI:29987	314322(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY modulate|nsubj|receptors modulate|dobj|capsaicin capsaicin|acl|induced induced|dobj|expression expression|amod|END_ENTITY	Non-NMDA glutamate receptors modulate capsaicin induced c-fos expression within trigeminal nucleus caudalis .
11798865	0	glutamate	82,91	c-fos	22,27	glutamate	c-fos	CHEBI:29987	314322(Tax:10116)	Chemical	Gene	-RSB-|amod|START_ENTITY induced|nmod|-RSB- induced|nsubj|effect effect|nmod|oligonucleotides oligonucleotides|amod|END_ENTITY	-LSB- Protective effect of c-fos antisense oligonucleotides on brain_damage induced by glutamate -RSB- .
12496939	0	glutamate	22,31	c-fos	67,72	glutamate	c-fos	CHEBI:29987	2353	Chemical	Gene	modulation|amod|START_ENTITY modulation|nmod|mRNA mRNA|amod|END_ENTITY	Group II metabotropic glutamate receptor modulation of DOI-induced c-fos mRNA and excitatory responses in the cerebral cortex .
1354554	0	glutamate	14,23	c-fos	39,44	glutamate	c-fos	CHEBI:29987	314322(Tax:10116)	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|nmod|expression expression|amod|END_ENTITY	The effect of glutamate antagonists on c-fos expression induced in spinal neurons by irritation of the lower urinary tract .
17120244	0	glutamate	77,86	c-fos	20,25	glutamate	c-fos	CHEBI:29987	314322(Tax:10116)	Chemical	Gene	mGlu5|amod|START_ENTITY mechanism|nmod|mGlu5 cells|nmod|mechanism END_ENTITY|nmod|cells	Glutamate activates c-fos in glial cells via a novel mechanism involving the glutamate receptor subtype mGlu5 and the transcriptional repressor DREAM .
18292343	3	glutamate	318,327	c-fos	488,493	glutamate	GluR1	CHEBI:29987	14799(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY dynamics|nmod|receptors dynamics|acl|induced induced|advcl|learning learning|advcl|using using|advcl|expressing expressing|dobj|subunit subunit|acl|fused fused|nmod|control control|nmod|promoter promoter|amod|END_ENTITY	We studied the dynamics of newly synthesized AMPA-type glutamate receptors -LRB- AMPARs -RRB- induced with learning using transgenic_mice expressing the GluR1 subunit fused to green fluorescent protein -LRB- GFP-GluR1 -RRB- under control of the c-fos promoter .
2539555	0	glutamate	97,106	c-fos	125,130	glutamate	c-fos	CHEBI:29987	2353	Chemical	Gene	receptors|compound|START_ENTITY activation|nmod|receptors induces|nsubj|activation induces|dobj|expression expression|amod|END_ENTITY	In primary cultures of cerebellar granule cells the activation of N-methyl-D-aspartate-sensitive glutamate receptors induces c-fos mRNA expression .
7790851	0	glutamate	124,133	c-fos	96,101	glutamate	c-fos	CHEBI:29987	14281(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY expression|acl|induced END_ENTITY|dep|expression	Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide potentiate c-fos expression induced by glutamate in cultured cortical neurons .
7994657	0	glutamate	10,19	c-fos	32,37	glutamate	c-fos	CHEBI:29987	314322(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY receptor|nmod|expression expression|amod|END_ENTITY	-LSB- Roles of glutamate receptor in c-fos gene expression and epilepsy susceptibility in rats -RSB- .
8427701	0	glutamate	11,20	c-fos	48,53	glutamate	c-fos	CHEBI:29987	2353	Chemical	Gene	subtypes|amod|START_ENTITY activate|nsubj|subtypes activate|dobj|transcription transcription|amod|END_ENTITY	Ionotropic glutamate receptor subtypes activate c-fos transcription by distinct calcium-requiring intracellular signaling pathways .
8748612	0	glutamate	26,35	c-fos	108,113	glutamate	c-fos	CHEBI:29987	314322(Tax:10116)	Chemical	Gene	antagonists|amod|START_ENTITY injections|nmod|antagonists modulate|nsubj|injections modulate|dobj|D1-mediated D1-mediated|acl|turning turning|dobj|expression expression|compound|END_ENTITY	Intranigral injections of glutamate antagonists modulate dopamine D1-mediated turning behavior and striatal c-fos expression .
8974658	0	glutamate	76,85	c-fos	25,30	glutamate	c-fos	CHEBI:29987	314322(Tax:10116)	Chemical	Gene	antagonists|amod|START_ENTITY inhibited|nmod|antagonists inhibited|nsubjpass|induction induction|nmod|END_ENTITY	Amphetamine induction of c-fos in the nucleus accumbens is not inhibited by glutamate antagonists .
9298238	0	glutamate	74,83	c-fos	38,43	glutamate	c-fos	CHEBI:29987	314322(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Recovery of hypothalamic NMDA-induced c-fos expression following neonatal glutamate -LRB- MSG -RRB- lesions .
9630506	0	glutamate	101,110	c-fos	35,40	glutamate	c-fos	CHEBI:29987	314322(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY striatum|nmod|receptor striatum|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of immediate early gene c-fos and zif/268 mRNA expression in rat striatum by metabotropic glutamate receptor .
9669313	0	glutamate	185,194	c-fos	106,111	glutamate	c-fos	CHEBI:29987	2353	Chemical	Gene	levels|nmod|START_ENTITY exposed|nmod|levels cells|acl|exposed levels|nmod|cells levels|amod|END_ENTITY	Calcium influx via L-type voltage-gated channels mediates the delayed , elevated increases in steady-state c-fos mRNA levels in cerebellar granule cells exposed to excitotoxic levels of glutamate .
11972176	0	glutamate	12,21	ca1	99,102	glutamate	ca1	CHEBI:29987	310218(Tax:10116)	Chemical	Gene	current|amod|START_ENTITY current|nmod|neurons neurons|nmod|sector sector|amod|END_ENTITY	-LSB- Effects of glutamate on transient outward potassium current of dissociated hippocampal neurons in ca1 sector in rats -RSB- .
21855531	0	glutamate	90,99	calcium-binding_protein_1	26,51	glutamate	calcium-binding protein 1	CHEBI:29987	9478	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Ca2 + - dependent binding of calcium-binding_protein_1 to presynaptic group III metabotropic glutamate receptors and blockage by phosphorylation of the receptors .
12021391	0	glutamate	67,76	calmodulin	115,125	glutamate	calmodulin	CHEBI:29987	808	Chemical	Gene	receptor|amod|START_ENTITY regulation|nmod|receptor Dissociation|nmod|regulation interactions|nsubj|Dissociation interactions|nmod|END_ENTITY	Dissociation of protein kinase-mediated regulation of metabotropic glutamate receptor 7 -LRB- mGluR7 -RRB- interactions with calmodulin and regulation of mGluR7 function .
21258069	0	glutamate	62,71	calmodulin	116,126	glutamate	calmodulin	CHEBI:29987	808	Chemical	Gene	receptor|compound|START_ENTITY domain|nmod|receptor Conformation|nmod|domain subtype|nsubj|Conformation subtype|nmod|END_ENTITY	Conformation of the calmodulin-binding domain of metabotropic glutamate receptor subtype 7 and its interaction with calmodulin .
21508217	0	glutamate	59,68	calmodulin	24,34	glutamate	calmodulin	D018698	808	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Differential binding of calmodulin to group I metabotropic glutamate receptors regulates receptor trafficking and signaling .
20811068	0	glutamate	54,63	cannabinoid_receptor_2	14,36	glutamate	cannabinoid receptor 2	CHEBI:29987	1269	Chemical	Gene	responses|compound|START_ENTITY responses|amod|END_ENTITY	Evaluation of cannabinoid_receptor_2 and metabotropic glutamate receptor 1 functional responses using a cell impedance-based technology .
15111253	0	glutamate	119,128	caspase-3	15,24	glutamate	caspase-3	CHEBI:29987	25402(Tax:10116)	Chemical	Gene	immunoreactivities|xcomp|START_ENTITY immunoreactivities|nsubj|Expressions Expressions|nmod|END_ENTITY	Expressions of caspase-3 , Tunel , and Hsp72 immunoreactivities in cultured spinal cord neurons of rat after exposure to glutamate , nitric_oxide , or peroxynitrite .
21730107	0	glutamate	66,75	caspase-3	183,192	glutamate	caspase-3	CHEBI:29987	25402(Tax:10116)	Chemical	Gene	transport|amod|START_ENTITY up-regulates|dobj|transport up-regulates|advcl|inhibiting inhibiting|dobj|inactivation inactivation|amod|END_ENTITY	The VPAC2 agonist peptide histidine_isoleucine -LRB- PHI -RRB- up-regulates glutamate transport in the corpus callosum of a rat model of amyotrophic_lateral_sclerosis -LRB- hSOD1G93A -RRB- by inhibiting caspase-3 mediated inactivation of GLT-1a .
23486571	0	glutamate	24,33	caspase-3	37,46	glutamate	caspase-3	CHEBI:29987	25402(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effect of antibodies to glutamate on caspase-3 activity in brain structures of rats with experimental Alzheimer 's _ disease .
23057965	0	glutamate	117,126	corticotrophin-releasing_factor	76,107	glutamate	corticotrophin-releasing factor	CHEBI:29987	81648(Tax:10116)	Chemical	Gene	neurons|amod|START_ENTITY END_ENTITY|nmod|neurons	Neuroprotection afforded by adenosine_A2A_receptor blockade is modulated by corticotrophin-releasing_factor -LRB- CRF -RRB- in glutamate injured cortical neurons .
11572969	0	glutamate	76,85	cyclin-dependent_kinase_5	14,39	glutamate	cyclin-dependent kinase 5	CHEBI:29987	12568(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY Regulation|nmod|receptors Regulation|nmod|END_ENTITY	Regulation of cyclin-dependent_kinase_5 and casein_kinase_1 by metabotropic glutamate receptors .
15056716	0	glutamate	270,279	cyclin-dependent_kinase_5	178,203	glutamate	cyclin-dependent kinase 5	CHEBI:29987	1020	Chemical	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun_N-terminal_kinase , cyclin-dependent_kinase_5 , and p38 mitogen-activated protein kinase as well as metabotropic glutamate receptor type 5 .
18541671	0	glutamate	55,64	epidermal_growth_factor_receptor	19,51	glutamate	epidermal growth factor receptor	CHEBI:29987	1956	Chemical	Gene	receptor|amod|START_ENTITY END_ENTITY|nmod|receptor	Essential role for epidermal_growth_factor_receptor in glutamate receptor signaling to NF-kappaB .
22711191	0	glutamate	109,118	erythropoietin	15,29	glutamate	erythropoietin	CHEBI:29987	24335(Tax:10116)	Chemical	Gene	cultured|nmod|START_ENTITY cultured|nsubj|effects effects|nmod|END_ENTITY	The effects of erythropoietin on RhoA/Rho-associated kinase expression in rat retinal explants cultured with glutamate .
10336676	0	glutamate	74,83	extracellular_signal-regulated_kinase_2	18,57	glutamate	extracellular signal-regulated kinase 2	CHEBI:29987	116590(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY Activation|nmod|receptors Activation|nmod|END_ENTITY	Activation of the extracellular_signal-regulated_kinase_2 by metabotropic glutamate receptors .
6148421	0	glutamate	50,59	folylpolyglutamate_synthetase	63,92	glutamate	folylpolyglutamate synthetase	CHEBI:29987	14287(Tax:10090)	Chemical	Gene	mechanism|nmod|START_ENTITY mechanism|nmod|END_ENTITY	A mechanism for the addition of multiple moles of glutamate by folylpolyglutamate_synthetase .
19436069	0	glutamate	71,80	fragile_X_mental_retardation_protein	94,130	glutamate	fragile X mental retardation protein	CHEBI:29987	14265(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY links|dobj|receptors links|xcomp|END_ENTITY	Ca2 + / calmodulin-dependent protein kinase IV links group I metabotropic glutamate receptors to fragile_X_mental_retardation_protein in cingulate cortex .
20554840	0	glutamate	72,81	fragile_X_mental_retardation_protein	12,48	glutamate	fragile X mental retardation protein	CHEBI:29987	14265(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY priming|nsubj|receptor decouples|xcomp|priming decouples|nsubj|Loss Loss|nmod|END_ENTITY	Loss of the fragile_X_mental_retardation_protein decouples metabotropic glutamate receptor dependent priming of long-term potentiation from protein synthesis .
21228181	0	glutamate	80,89	fragile_X_mental_retardation_protein	19,55	glutamate	fragile X mental retardation protein	CHEBI:29987	14265(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Dual regulation of fragile_X_mental_retardation_protein by group I metabotropic glutamate receptors controls translation-dependent epileptogenesis in the hippocampus .
26777117	0	glutamate	77,86	fyn	56,59	glutamate	fyn	D018698	25150(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Dopamine D2 receptors are involved in the regulation of fyn and metabotropic glutamate receptor 5 phosphorylation in the rat striatum in vivo .
15993	0	glutamate	62,71	gamma-glutamylcysteine_synthetase	88,121	glutamate	gamma-glutamylcysteine synthetase	CHEBI:29987	2729	Chemical	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Covalent interaction of L-2-amino-4-oxo-5-chloropentanoate at glutamate binding site of gamma-glutamylcysteine_synthetase .
1310861	0	glutamate	63,72	gamma_2	40,47	glutamate	gamma 2	CHEBI:29987	14406(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY subunit|nmod|receptor subunit|amod|END_ENTITY	Primary structure and expression of the gamma_2 subunit of the glutamate receptor channel selective for kainate .
9654363	0	glutamate	79,88	glial_fibrillary_acidic_protein	37,68	glutamate	glial fibrillary acidic protein	CHEBI:29987	24387(Tax:10116)	Chemical	Gene	ions|compound|START_ENTITY END_ENTITY|nmod|ions	Regulation of the phosphorylation of glial_fibrillary_acidic_protein -LRB- GFAP -RRB- by glutamate and calcium ions in slices of immature rat spinal cord : comparison with immature hippocampus .
11439453	0	glutamate	28,37	glr-1	48,53	glutamate	glr-1	CHEBI:29987	176204(Tax:6239)	Chemical	Gene	receptor|compound|START_ENTITY mutation|nmod|receptor mutation|amod|END_ENTITY	A mutation in the AMPA-type glutamate receptor , glr-1 , blocks olfactory associative and nonassociative learning in Caenorhabditis_elegans .
11181711	0	glutamate	57,66	glutamate_dehydrogenase	16,39	glutamate	glutamate dehydrogenase	CHEBI:29987	102585678	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	Contribution of glutamate_dehydrogenase to mitochondrial glutamate metabolism studied by -LRB- 13 -RRB- C and -LRB- 31 -RRB- P nuclear magnetic resonance .
12193607	0	glutamate	14,23	glutamate_dehydrogenase	62,85	glutamate	glutamate dehydrogenase	CHEBI:29987	2746	Chemical	Gene	Importance|nmod|START_ENTITY 279|nsubj|Importance 279|nmod|coenzyme coenzyme|nmod|END_ENTITY	Importance of glutamate 279 for the coenzyme binding of human glutamate_dehydrogenase .
14532172	0	glutamate	110,119	glutamate_dehydrogenase	43,66	glutamate	glutamate dehydrogenase	CHEBI:29987	2746	Chemical	Gene	oxidation|compound|START_ENTITY induces|nmod|oxidation induces|nsubj|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of constitutively activated glutamate_dehydrogenase induces insulin secretion through enhanced glutamate oxidation .
19625687	0	glutamate	14,23	glutamate_dehydrogenase	60,83	glutamate	glutamate dehydrogenase	CHEBI:29987	2746	Chemical	Gene	metabolism|amod|START_ENTITY Regulation|nmod|metabolism secretion|nsubj|Regulation secretion|nmod|END_ENTITY	Regulation of glutamate metabolism and insulin secretion by glutamate_dehydrogenase in hypoglycemic children .
21063099	0	glutamate	94,103	glutamate_dehydrogenase	61,84	glutamate	glutamate dehydrogenase	CHEBI:29987	2746	Chemical	Gene	deamination|compound|START_ENTITY deamination|amod|END_ENTITY	Troglitazone regulates anaplerosis via a pull/push affect on glutamate_dehydrogenase mediated glutamate deamination in kidney-derived epithelial cells ; implications for the Warburg effect .
22542772	0	glutamate	152,161	glutamate_dehydrogenase	20,43	glutamate	glutamate dehydrogenase	CHEBI:29987	2746	Chemical	Gene	amino_acids|amod|START_ENTITY accumulation|nmod|amino_acids affects|nmod|accumulation affects|advmod|down down|nmod|END_ENTITY	siRNA knock down of glutamate_dehydrogenase in astrocytes affects glutamate metabolism leading to extensive accumulation of the neuroactive amino_acids glutamate and aspartate .
22542772	0	glutamate	66,75	glutamate_dehydrogenase	20,43	glutamate	glutamate dehydrogenase	CHEBI:29987	2746	Chemical	Gene	metabolism|amod|START_ENTITY affects|dobj|metabolism affects|advmod|down down|nmod|END_ENTITY	siRNA knock down of glutamate_dehydrogenase in astrocytes affects glutamate metabolism leading to extensive accumulation of the neuroactive amino_acids glutamate and aspartate .
2424780	0	glutamate	48,57	glutamate_dehydrogenase	85,108	glutamate	glutamate dehydrogenase	CHEBI:29987	2746	Chemical	Gene	demonstration|nmod|START_ENTITY uptake|nsubj|demonstration uptake|nmod|reaction reaction|amod|END_ENTITY	Histochemical demonstration of sodium-dependent glutamate uptake in brain tissues by glutamate_dehydrogenase reaction .
18941757	0	glutamate	32,41	glutamate_receptor	56,74	glutamate	glutamate receptor	CHEBI:29987	33788(Tax:7227)	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of ambient extracellular glutamate on Drosophila glutamate_receptor trafficking and function .
16277616	0	glutamate	67,76	glycogen_synthase_kinase_3beta	18,48	glutamate	glycogen synthase kinase 3beta	CHEBI:29987	84027(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	The inhibition of glycogen_synthase_kinase_3beta by a metabotropic glutamate receptor 5 mediated pathway confers neuroprotection to Abeta peptides .
11157079	0	glutamate	52,61	gnrh	103,107	glutamate	gnrh	CHEBI:29987	14714(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY Differing|nmod|receptors Differing|acl|regulating regulating|dobj|migration migration|nmod|neurons neurons|amod|END_ENTITY	Differing , spatially restricted roles of ionotropic glutamate receptors in regulating the migration of gnrh neurons during embryogenesis .
12574434	0	glutamate	52,61	gria1	71,76	glutamate	gria1	CHEBI:29987	14799(Tax:10090)	Chemical	Gene	mice|amod|START_ENTITY mice|compound|END_ENTITY	Selective disruption of stimulus-reward learning in glutamate receptor gria1 knock-out mice .
14573529	0	glutamate	87,96	gria2	106,111	glutamate	gria2	CHEBI:29987	14800(Tax:10090)	Chemical	Gene	mice|amod|START_ENTITY mice|compound|END_ENTITY	Involvement of AMPA receptor GluR2 subunits in stimulus-reward learning : evidence from glutamate receptor gria2 knock-out mice .
2018562	0	glutamate	48,57	growth_hormone	98,112	glutamate	growth hormone	CHEBI:29987	81668(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|acl|circulating circulating|dobj|END_ENTITY	Differential effects of neonatally administered glutamate on the ultradian pattern of circulating growth_hormone regulating expression of sex-dependent forms of cytochrome P450 .
7918660	0	glutamate	6,15	hGluR3	25,31	glutamate	hGluR3	CHEBI:29987	2892	Chemical	Gene	flip|compound|START_ENTITY flip|amod|END_ENTITY	Human glutamate receptor hGluR3 flip and flop isoforms : cloning and sequencing of the cDNAs and primary structure of the proteins .
7621914	0	glutamate	67,76	hGluT-1	120,127	glutamate	hGluT-1	CHEBI:29987	6513	Chemical	Gene	uptake|amod|START_ENTITY uptake|nmod|END_ENTITY	Inhibition by folded isomers of L-2 - -LRB- carboxycyclopropyl -RRB- glycine of glutamate uptake via the human glutamate transporter hGluT-1 .
9562319	0	glutamate	40,49	hGluT-1	92,99	glutamate	hGluT-1	CHEBI:29987	6513	Chemical	Gene	transport|amod|START_ENTITY transport|nmod|END_ENTITY	Effect of amino_acid ergot alkaloids on glutamate transport via human glutamate transporter hGluT-1 .
11815466	0	glutamate	15,24	insulin	44,51	glutamate	insulin	CHEBI:29987	3630	Chemical	Gene	START_ENTITY|nmod|kinetics kinetics|nmod|secretion secretion|compound|END_ENTITY	Implication of glutamate in the kinetics of insulin secretion in rat and mouse perfused pancreas .
12047489	0	glutamate	31,40	insulin	44,51	glutamate	insulin	CHEBI:29987	3630	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Effects of oral monosodium -LRB- L -RRB- - glutamate on insulin secretion and glucose tolerance in healthy volunteers .
9868050	0	glutamate	12,21	interleukin_6	33,46	glutamate	interleukin 6	CHEBI:29987	24498(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|production production|amod|END_ENTITY	-LSB- Effects of glutamate and ATP on interleukin_6 production by cultured neonatal rat astrocyte -RSB- .
18685025	0	glutamate	89,98	kisspeptin	53,63	glutamate	kisspeptin	CHEBI:29987	280287(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|END_ENTITY	Excitatory effects of the puberty-initiating peptide kisspeptin and group I metabotropic glutamate receptor agonists differentiate two distinct subpopulations of gonadotropin-releasing_hormone neurons .
20091783	0	glutamate	19,28	mGLU3	0,5	glutamate	mGLU3	CHEBI:29987	108069(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	mGLU3 metabotropic glutamate receptors modulate the differentiation of SVZ-derived neural stem cells towards the astrocytic lineage .
7608756	0	glutamate	13,22	mGLuR2	101,107	glutamate	mGLuR2	CHEBI:29987	14800(Tax:10090)	Chemical	Gene	presynaptic_depression|amod|START_ENTITY involves|nsubj|presynaptic_depression involves|dobj|END_ENTITY	Metabotropic glutamate receptor-mediated presynaptic_depression at corticostriatal synapses involves mGLuR2 or 3 .
16123306	0	glutamate	51,60	mGlu2/3	118,125	glutamate	mGlu2/3	CHEBI:29987	108069(Tax:10090)	Chemical	Gene	potentiator|nmod|START_ENTITY effects|nsubj|potentiator effects|dobj|predictive predictive|amod|similar similar|nmod|agonist agonist|amod|END_ENTITY	A selective allosteric potentiator of metabotropic glutamate -LRB- mGlu -RRB- 2 receptors has effects similar to an orthosteric mGlu2/3 receptor agonist in mouse models predictive of antipsychotic activity .
17196590	0	glutamate	51,60	mGlu2/3	30,37	glutamate	mGlu2/3	CHEBI:29987	108069(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Pharmacological activation of mGlu2/3 metabotropic glutamate receptors protects retinal neurons against anoxic_damage in the goldfish Carassius_auratus .
19439499	0	glutamate	35,44	mGlu2/3	14,21	glutamate	mGlu2/3	CHEBI:29987	108069(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Activation of mGlu2/3 metabotropic glutamate receptors negatively regulates the stimulation of inositol phospholipid hydrolysis mediated by 5-hydroxytryptamine2A serotonin receptors in the frontal cortex of living mice .
20371233	0	glutamate	22,31	mGlu2/3	43,50	glutamate	mGlu2/3	CHEBI:29987	108069(Tax:10090)	Chemical	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Group II metabotropic glutamate receptors -LRB- mGlu2/3 -RRB- in drug_addiction .
10457374	0	glutamate	51,60	mGlu3	32,37	glutamate	mGlu3	CHEBI:29987	108069(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Activation of A -LRB- 1 -RRB- adenosine or mGlu3 metabotropic glutamate receptors enhances the release of nerve_growth_factor and S-100beta protein from cultured astrocytes .
12887692	0	glutamate	101,110	mGlu3	71,76	glutamate	mGlu3	CHEBI:29987	108069(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY subtype|nmod|receptor subtype|amod|END_ENTITY	Molecular modeling and mutagenesis of the ligand-binding pocket of the mGlu3 subtype of metabotropic glutamate receptor .
18424625	0	glutamate	38,47	mGlu3	60,65	glutamate	mGlu3	CHEBI:29987	108069(Tax:10090)	Chemical	Gene	receptors|nmod|START_ENTITY receptors|compound|END_ENTITY	Evidence for the role of metabotropic glutamate -LRB- mGlu -RRB- 2 not mGlu3 receptors in the preclinical antipsychotic pharmacology of the mGlu2/3 receptor agonist -LRB- - -RRB- - -LRB- 1R ,4 S ,5 S ,6 S -RRB- -4 - amino-2-sulfonylbicyclo -LSB- 3.1.0 -RSB- hexane-4 ,6 - dicarboxylic_acid -LRB- LY404039 -RRB- .
22607673	0	glutamate	52,61	mGlu3	74,79	glutamate	mGlu3	CHEBI:29987	108069(Tax:10090)	Chemical	Gene	probe|amod|START_ENTITY probe|appos|END_ENTITY	Development of a novel , CNS-penetrant , metabotropic glutamate receptor 3 -LRB- mGlu3 -RRB- NAM probe -LRB- ML289 -RRB- derived from a closely related mGlu5 PAM .
23762947	0	glutamate	164,173	mGlu3	35,40	glutamate	mGlu3	CHEBI:29987	108069(Tax:10090)	Chemical	Gene	mGlu3|amod|START_ENTITY modulators|compound|mGlu3 probe|compound|modulators discovery|nmod|probe report|dobj|discovery Herein|acl:relcl|report Hit|dobj|Herein Hit|nsubj|Development Development|nmod|NAM NAM|compound|END_ENTITY	Development of the First Selective mGlu3 NAM from an mGlu5 PAM Hit Herein we report the discovery and structure activity relationship -LRB- SAR -RRB- of a novel metabotropic glutamate receptor 3 -LRB- mGlu3 -RRB- negative allosteric modulators -LRB- NAM -RRB- probe -LRB- ML289 -RRB- with 15-fold selectivity versus mGlu2 -LRB- IC50 > 10 M -RRB- .
23885366	0	glutamate	167,176	mGlu3	35,40	glutamate	mGlu3	CHEBI:29987	108069(Tax:10090)	Chemical	Gene	mGlu3|compound|START_ENTITY report|dep|mGlu3 Herein|acl:relcl|report Herein|nsubj|Development Development|nmod|NAM NAM|compound|END_ENTITY	Development of a Second Generation mGlu3 NAM Probe Herein we report the discovery and structure activity relationship -LRB- SAR -RRB- of a novel , second generation metabotropic glutamate receptor 3 -LRB- mGlu3 -RRB- negative allosteric modulator -LRB- NAM -RRB- probe -LRB- ML337 -RRB- with > 50-fold selectivity versus mGlu2 -LRB- IC50 > 30 M -RRB- .
25434487	0	glutamate	33,42	mGlu3	14,19	glutamate	mGlu3	CHEBI:29987	108069(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Activation of mGlu3 metabotropic glutamate receptors enhances GDNF and GLT-1 formation in the spinal cord and rescues motor neurons in the SOD-1 mouse model of amyotrophic_lateral_sclerosis .
25160592	0	glutamate	17,26	mGlu5	37,42	glutamate	mGlu5	CHEBI:29987	2915	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	The metabotropic glutamate receptor , mGlu5 , is required for extinction learning that occurs in the absence of a context change .
10229625	0	glutamate	128,137	mGluR1	23,29	glutamate	mGluR1	CHEBI:29987	14799(Tax:10090)	Chemical	Gene	conformation|compound|START_ENTITY recognition|nmod|conformation environment|nmod|recognition selectivity|dep|environment selectivity|nmod|END_ENTITY	Agonist selectivity of mGluR1 and mGluR2 metabotropic receptors : a different environment but similar recognition of an extended glutamate conformation .
10395931	0	glutamate	107,116	mGluR1	126,132	glutamate	mGluR1	CHEBI:29987	14799(Tax:10090)	Chemical	Gene	mRNA1|compound|START_ENTITY mRNA1|amod|END_ENTITY	Identification , cloning and analysis of expression of a new alternatively spliced form of the metabotropic glutamate receptor mGluR1 mRNA1 .
10400956	0	glutamate	21,30	mGluR1	48,54	glutamate	mGluR1	CHEBI:29987	14799(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY Role|nmod|receptor subtype|nsubj|Role subtype|dobj|END_ENTITY	Role of metabotropic glutamate receptor subtype mGluR1 in brief nociception and central sensitization of primate STT cells .
10744030	0	glutamate	64,73	mGluR1	107,113	glutamate	mGluR1	CHEBI:29987	14799(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY up-regulation|nmod|receptors up-regulation|dep|changes changes|nmod|mRNA mRNA|amod|END_ENTITY	Temporal_lobe_epilepsy associated up-regulation of metabotropic glutamate receptors : correlated changes in mGluR1 mRNA and protein expression in experimental animals and human patients .
11524158	0	glutamate	49,58	mGluR1	131,137	glutamate	mGluR1	CHEBI:29987	14799(Tax:10090)	Chemical	Gene	modulation|nmod|START_ENTITY receptors|amod|modulation mediated|nsubj|receptors mediated|nmod|END_ENTITY	Presynaptic modulation by group III metabotropic glutamate receptors -LRB- mGluRs -RRB- of the excitatory postsynaptic potential mediated by mGluR1 in rat cerebellar Purkinje cells .
12623213	0	glutamate	38,47	mGluR1	132,138	glutamate	mGluR1	CHEBI:29987	14799(Tax:10090)	Chemical	Gene	subtypes|compound|START_ENTITY Determination|nmod|subtypes involved|nsubj|Determination involved|nmod|mice mice|amod|vitro vitro|dep|using using|dobj|END_ENTITY	Determination of group I metabotropic glutamate receptor subtypes involved in the frequency of epileptiform_activity in vitro using mGluR1 and mGluR5 mutant mice .
1314623	0	glutamate	74,83	mGluR1	94,100	glutamate	mGluR1	CHEBI:29987	14799(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Signal transduction and pharmacological characteristics of a metabotropic glutamate receptor , mGluR1 , in transfected CHO cells .
1316979	0	glutamate	74,83	mGluR1	96,102	glutamate	mGluR1	CHEBI:29987	14799(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|receptor receptor|appos|END_ENTITY	Depolarization - and agonist-regulated expression of neuronal metabotropic glutamate receptor 1 -LRB- mGluR1 -RRB- .
1430307	0	glutamate	44,53	mGluR1	64,70	glutamate	mGluR1	CHEBI:29987	14799(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Distribution of the mRNA for a metabotropic glutamate receptor -LRB- mGluR1 -RRB- in the central nervous system : an in situ hybridization study in adult and developing rat .
16178731	0	glutamate	60,69	mGluR1	90,96	glutamate	mGluR1	CHEBI:29987	14799(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY modulators|nmod|receptor subtype|nsubj|modulators subtype|dobj|1 1|appos|END_ENTITY	Subtype-selective noncompetitive modulators of metabotropic glutamate receptor subtype 1 -LRB- mGluR1 -RRB- .
16870174	0	glutamate	36,45	mGluR1	56,62	glutamate	mGluR1	CHEBI:29987	14799(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|dep|alpha alpha|dep|END_ENTITY	Distinct regulation of metabotropic glutamate receptor -LRB- mGluR1 alpha -RRB- in the developing limbic system following multiple early-life seizures .
17004925	7	glutamate	1396,1405	mGluR1	1418,1424	glutamate	mGluR1	CHEBI:29987	14799(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Although metabotropic glutamate receptor 1 -LRB- mGluR1 -RRB- has been suggested as a possible downstream target of ERK1/2 in cell-culture preparations , mGluR1-activated slow excitatory postsynaptic currents -LRB- EPSCs -RRB- were not affected by U0126 treatment in slices .
17929793	0	glutamate	57,66	mGluR1	79,85	glutamate	mGluR1	CHEBI:29987	14799(Tax:10090)	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|amod|1 1|dep|END_ENTITY	Discovery of orally efficacious tetracyclic metabotropic glutamate receptor 1 -LRB- mGluR1 -RRB- antagonists for the treatment of chronic_pain .
18003824	0	glutamate	27,36	mGluR1	110,116	glutamate	mGluR1	CHEBI:29987	14799(Tax:10090)	Chemical	Gene	release|nmod|START_ENTITY regulates|nsubj|release regulates|nmod|cells cells|nmod|activation activation|amod|END_ENTITY	Somatodendritic release of glutamate regulates synaptic inhibition in cerebellar Purkinje cells via autocrine mGluR1 activation .
18174329	0	glutamate	10,19	mGluR1	61,67	glutamate	mGluR1	CHEBI:29987	14799(Tax:10090)	Chemical	Gene	release|compound|START_ENTITY produces|nsubj|release produces|dobj|activation activation|nmod|END_ENTITY	Dendritic glutamate release produces autocrine activation of mGluR1 in cerebellar Purkinje cells .
18364018	0	glutamate	13,22	mGluR1	35,41	glutamate	mGluR1	CHEBI:29987	14799(Tax:10090)	Chemical	Gene	START_ENTITY|ccomp|regulate regulate|nsubj|receptor receptor|appos|END_ENTITY	Metabotropic glutamate receptor 1 -LRB- mGluR1 -RRB- and 5 -LRB- mGluR5 -RRB- regulate late phases of LTP and LTD in the hippocampal CA1 region in vitro .
19542684	0	glutamate	50,59	mGluR1	139,145	glutamate	mGluR1	CHEBI:29987	14799(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY occupancy|nmod|receptor Correlation|nmod|occupancy subtype|nsubj|Correlation subtype|nmod|activity activity|nmod|antagonists antagonists|amod|END_ENTITY	Correlation of receptor occupancy of metabotropic glutamate receptor subtype 1 -LRB- mGluR1 -RRB- in mouse brain with in vivo activity of allosteric mGluR1 antagonists .
19542684	0	glutamate	50,59	mGluR1	80,86	glutamate	mGluR1	CHEBI:29987	14799(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY occupancy|nmod|receptor Correlation|nmod|occupancy subtype|nsubj|Correlation subtype|dobj|1 1|appos|END_ENTITY	Correlation of receptor occupancy of metabotropic glutamate receptor subtype 1 -LRB- mGluR1 -RRB- in mouse brain with in vivo activity of allosteric mGluR1 antagonists .
20705606	0	glutamate	74,83	mGluR1	103,109	glutamate	mGluR1	CHEBI:29987	14799(Tax:10090)	Chemical	Gene	alpha|compound|START_ENTITY alpha|dep|END_ENTITY	Elucidation of a novel extracellular calcium-binding site on metabotropic glutamate receptor 1 -LCB- alpha -RCB- -LRB- mGluR1 -LCB- alpha -RCB- -RRB- that controls receptor activation .
22316010	0	glutamate	104,113	mGluR1	134,140	glutamate	mGluR1	CHEBI:29987	14799(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY imaging|nmod|receptor radioligands|nmod|imaging Synthesis|nmod|radioligands subtype|nsubj|Synthesis subtype|dobj|1 1|appos|END_ENTITY	Synthesis and evaluation of novel radioligands for positron emission tomography imaging of metabotropic glutamate receptor subtype 1 -LRB- mGluR1 -RRB- in rodent brain .
23348064	0	glutamate	13,22	mGluR1	35,41	glutamate	mGluR1	D018698	14799(Tax:10090)	Chemical	Gene	I|amod|START_ENTITY I|appos|END_ENTITY	Metabotropic glutamate receptor I -LRB- mGluR1 -RRB- antagonism impairs cocaine-induced conditioned place preference via inhibition of protein_synthesis .
23385114	0	glutamate	19,28	mGluR1	94,100	glutamate	mGluR1	CHEBI:29987	14799(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY Using|dobj|receptors Using|parataxis|finds finds|nsubj|END_ENTITY	Using metabotropic glutamate receptors to modulate cocaine 's synaptic and behavioral effects : mGluR1 finds a niche .
24147864	0	glutamate	199,208	mGluR1	221,227	glutamate	mGluR1	CHEBI:29987	14799(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|receptor receptor|appos|END_ENTITY	Synthesis and evaluation in monkey of -LSB- -LRB- 18 -RRB- F -RSB- 4-fluoro-N-methyl-N - -LRB- 4 - -LRB- 6 - -LRB- methylamino -RRB- pyrimidin-4-yl -RRB- thiazol-2-yl -RRB- benzamide -LRB- -LSB- -LRB- 18 -RRB- F -RSB- FIMX -RRB- : a promising radioligand for PET imaging of brain metabotropic glutamate receptor 1 -LRB- mGluR1 -RRB- .
24635567	0	glutamate	38,47	mGluR1	65,71	glutamate	mGluR1	CHEBI:29987	14799(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Molecular recognition of metabotropic glutamate receptor type 1 -LRB- mGluR1 -RRB- : synergistic understanding with free energy perturbation and linear response modeling .
7551173	0	glutamate	45,54	mGluR1	66,72	glutamate	mGluR1	CHEBI:29987	14799(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY mRNA|nmod|receptors Expression|nmod|mRNA Expression|dep|7 7|compound|END_ENTITY	Expression of the mRNA of seven metabotropic glutamate receptors -LRB- mGluR1 to 7 -RRB- in the rat retina .
7636026	0	glutamate	70,79	mGluR1	91,97	glutamate	mGluR1	CHEBI:29987	14799(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY study|nmod|receptors study|appos|alpha alpha|amod|END_ENTITY	Immunohistochemical study of two phosphoinositide-linked metabotropic glutamate receptors -LRB- mGluR1 alpha and mGluR5 -RRB- in the cat visual cortex before , during , and after the peak of the critical period for eye-specific connections .
7690672	0	glutamate	83,92	mGluR1	42,48	glutamate	mGluR1	CHEBI:29987	14799(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY subtype|nmod|receptor subtype|amod|alpha alpha|dep|END_ENTITY	A pharmacological characterization of the mGluR1 alpha subtype of the metabotropic glutamate receptor expressed in a cloned baby hamster kidney cell line .
7751958	0	glutamate	80,89	mGluR1	139,145	glutamate	mGluR1	CHEBI:29987	14799(Tax:10090)	Chemical	Gene	type|amod|START_ENTITY characterization|nmod|type characterization|dep|comparison comparison|nmod|END_ENTITY	Molecular , functional , and pharmacological characterization of the metabotropic glutamate receptor type 5 splice variants : comparison with mGluR1 .
7860792	0	glutamate	13,22	mGluR1	32,38	glutamate	mGluR1	CHEBI:29987	14799(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|distribution distribution|amod|END_ENTITY	Metabotropic glutamate receptor mGluR1 distribution and ultrastructural localization in hypothalamus .
7881038	0	glutamate	87,96	mGluR1	67,73	glutamate	mGluR1	CHEBI:29987	14799(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Differential cellular localization of three splice variants of the mGluR1 metabotropic glutamate receptor in rat cerebellum .
7912091	0	glutamate	44,53	mGluR1	24,30	glutamate	mGluR1	CHEBI:29987	14799(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|nummod|END_ENTITY	Antibodies inactivating mGluR1 metabotropic glutamate receptor block long-term depression in cultured Purkinje cells .
7922022	0	glutamate	100,109	mGluR1	80,86	glutamate	mGluR1	CHEBI:29987	14799(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	A subpopulation of cerebellar granule neurons in culture expresses a functional mGluR1 metabotropic glutamate receptor : effect of depolarizing growing conditions .
8104433	0	glutamate	17,26	mGluR1	37,43	glutamate	mGluR1	CHEBI:29987	14799(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|dep|alpha alpha|dep|END_ENTITY	The metabotropic glutamate receptor -LRB- mGluR1 alpha -RRB- is concentrated at perisynaptic membrane of neuronal subpopulations as detected by immunogold reaction .
8230318	0	glutamate	31,40	mGluR1	50,56	glutamate	mGluR1	CHEBI:29987	14799(Tax:10090)	Chemical	Gene	Expression|nmod|START_ENTITY receptor|nsubj|Expression receptor|dobj|GluR1 GluR1|amod|END_ENTITY	Expression of the metabotropic glutamate receptor mGluR1 alpha and the ionotropic glutamate receptor GluR1 in the brain during the postnatal development of normal mouse and in the cerebellum from mutant mice .
8386753	0	glutamate	66,75	mGluR1	86,92	glutamate	mGluR1	CHEBI:29987	14799(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Differential localization of phosphoinositide-linked metabotropic glutamate receptor -LRB- mGluR1 -RRB- and the inositol_1 ,4,5 - trisphosphate receptor in rat brain .
8667026	0	glutamate	49,58	mGluR1	29,35	glutamate	mGluR1	CHEBI:29987	14799(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	The C-terminal domain of the mGluR1 metabotropic glutamate receptor affects sensitivity to agonists .
8758956	0	glutamate	38,47	mGluR1	58,64	glutamate	mGluR1	CHEBI:29987	14799(Tax:10090)	Chemical	Gene	location|nmod|START_ENTITY receptors|nsubj|location receptors|dobj|END_ENTITY	Perisynaptic location of metabotropic glutamate receptors mGluR1 and mGluR5 on dendrites and dendritic spines in the rat hippocampus .
9147399	0	glutamate	13,22	mGluR1	49,55	glutamate	mGluR1	CHEBI:29987	14799(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|receptor receptor|dep|alpha alpha|dep|END_ENTITY	Metabotropic glutamate receptor subtype-1 alpha -LRB- mGluR1 alpha -RRB- immunoreactivity in ependymal cells of the rat caudal medulla oblongata and spinal cord .
9285353	0	glutamate	105,114	mGluR1	79,85	glutamate	mGluR1	CHEBI:29987	14799(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|alpha alpha|dep|END_ENTITY	A monoclonal antibody shows discrete cellular and subcellular localizations of mGluR1 alpha metabotropic glutamate receptors .
9412905	0	glutamate	58,67	mGluR1	78,84	glutamate	mGluR1	CHEBI:29987	14799(Tax:10090)	Chemical	Gene	distribution|nmod|START_ENTITY receptors|nsubj|distribution receptors|dobj|sites sites|amod|END_ENTITY	Differential plasma membrane distribution of metabotropic glutamate receptors mGluR1 alpha , mGluR2 and mGluR5 , relative to neurotransmitter release sites .
9779943	0	glutamate	64,73	mGluR1	158,164	glutamate	mGluR1	CHEBI:29987	14799(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY localization|nmod|receptor localization|dep|evidence evidence|nmod|distribution distribution|nmod|variants variants|amod|END_ENTITY	Immunohistochemical localization of the mGluR1beta metabotropic glutamate receptor in the adult rodent forebrain : evidence for a differential distribution of mGluR1 splice variants .
15837331	0	glutamate	156,165	mGluR2	178,184	glutamate	mGluR2	CHEBI:29987	14800(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	3 - -LRB- 2-Ethoxy-4 - -LCB- 4 - -LSB- 3-hydroxy-2-methyl-4 - -LRB- 3-methylbutanoyl -RRB- phenoxy -RSB- butoxy -RCB- phenyl -RRB- propanoic_acid : a brain penetrant allosteric potentiator at the metabotropic glutamate receptor 2 -LRB- mGluR2 -RRB- .
16005222	0	glutamate	54,63	mGluR2	76,82	glutamate	mGluR2	CHEBI:29987	14800(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Benzazoles as allosteric potentiators of metabotropic glutamate receptor 2 -LRB- mGluR2 -RRB- : efficacy in an animal model for schizophrenia .
16178732	0	glutamate	51,60	mGluR2	81,87	glutamate	mGluR2	CHEBI:29987	14800(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY modulators|nmod|receptor subtype|nsubj|modulators subtype|dobj|2 2|appos|END_ENTITY	Positive allosteric modulators of the metabotropic glutamate receptor subtype 2 -LRB- mGluR2 -RRB- .
21115084	0	glutamate	20,29	mGluR2	40,46	glutamate	mGluR2	CHEBI:29987	14800(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Type 2 metabotropic glutamate receptor -LRB- mGluR2 -RRB- fails to negatively couple to cGMP in stably transfected cells .
21155570	0	glutamate	54,63	mGluR2	84,90	glutamate	mGluR2	CHEBI:29987	14800(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY Design|nmod|receptor subtype-2|nsubj|Design subtype-2|dep|END_ENTITY	Design and synthesis of an orally active metabotropic glutamate receptor subtype-2 -LRB- mGluR2 -RRB- positive allosteric modulator -LRB- PAM -RRB- that decreases cocaine self-administration in rats .
21232953	0	glutamate	55,64	mGluR2	77,83	glutamate	mGluR2	CHEBI:29987	14800(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	New positive allosteric modulators of the metabotropic glutamate receptor 2 -LRB- mGluR2 -RRB- : identification and synthesis of N-propyl-8-chloro-6-substituted_isoquinolones .
26686390	0	glutamate	74,83	mGluR2	94,100	glutamate	mGluR2	D018698	14800(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY markers|nmod|receptor markers|appos|END_ENTITY	Translational neurophysiological markers for activity of the metabotropic glutamate receptor -LRB- mGluR2 -RRB- modulator JNJ-40411813 : Sleep EEG correlates in rodents and healthy men .
8043281	0	glutamate	49,58	mGluR2	70,76	glutamate	mGluR2	CHEBI:29987	14800(Tax:10090)	Chemical	Gene	START_ENTITY|dep|receptors receptors|nummod|END_ENTITY	Immunohistochemical localization of metabotropic glutamate receptors , mGluR2 and mGluR3 , in rat cerebellar cortex .
8389425	0	glutamate	53,62	mGluR2	73,79	glutamate	mGluR2	CHEBI:29987	14800(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Distribution of the messenger RNA for a metabotropic glutamate receptor , mGluR2 , in the central nervous system of the rat .
8684625	0	glutamate	17,26	mGluR2	38,44	glutamate	mGluR2	CHEBI:29987	14800(Tax:10090)	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	The metabotropic glutamate receptors , mGluR2 and mGluR3 , show unique postsynaptic , presynaptic and glial localizations .
8848265	0	glutamate	53,62	mGluR2	73,79	glutamate	mGluR2	CHEBI:29987	14800(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Pre - and postsynaptic localization of a metabotropic glutamate receptor , mGluR2 , in the rat brain : an immunohistochemical study with a monoclonal antibody .
8951875	0	glutamate	13,22	mGluR2	33,39	glutamate	mGluR2	CHEBI:29987	14800(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Metabotropic glutamate receptors mGluR2 and mGluR5 are expressed in two non-overlapping populations of Golgi cells in the rat cerebellum .
9572581	0	glutamate	31,40	mGluR2	51,57	glutamate	mGluR2	CHEBI:29987	14800(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Distribution of a metabotropic glutamate receptor , mGluR2 , in the central nervous system of the rat and mouse : an immunohistochemical study with a monoclonal antibody .
10363950	0	glutamate	13,22	mGluR2/3	32,40	glutamate	mGluR2/3	CHEBI:29987	108069(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|dep|colliculus colliculus|amod|END_ENTITY	Metabotropic glutamate receptor mGluR2/3 immunoreactivity in the mouse superior colliculus : co-localization with calbindin_D28K .
10446317	0	glutamate	98,107	mGluR2/3	118,126	glutamate	mGluR2/3	CHEBI:29987	108068;108069;14800;53623	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Interstitial glial cells of the gerbil pineal gland display immunoreactivity for the metabotropic glutamate receptors mGluR2/3 and mGluR5 .
20831878	0	glutamate	99,108	mGluR2/3	77,85	glutamate	mGluR2/3	CHEBI:29987	108068;108069;14800;53623	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Positive and negative modulation of circadian activity rhythms by mGluR5 and mGluR2/3 metabotropic glutamate receptors .
21334855	0	glutamate	24,33	mGluR2/3	53,61	glutamate	mGluR2/3	CHEBI:29987	108068;108069;14800;53623	Chemical	Gene	receptors|compound|START_ENTITY differ|nmod|receptors differ|nsubj|2 2|appos|END_ENTITY	Density of metabotropic glutamate receptors 2 and 3 -LRB- mGluR2/3 -RRB- in the dorsolateral prefrontal cortex does not differ with schizophrenia diagnosis but decreases with age .
10533045	0	glutamate	51,60	mGluR3	0,6	glutamate	mGluR3	CHEBI:29987	53623(Tax:10090)	Chemical	Gene	mRNAs|amod|START_ENTITY mRNAs|nsubj|END_ENTITY	mGluR3 and mGluR5 are the predominant metabotropic glutamate receptor mRNAs expressed in hippocampal astrocytes acutely isolated from young rats .
10947812	0	glutamate	29,38	mGluR3	56,62	glutamate	mGluR3	CHEBI:29987	53623(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY Upregulation|nmod|receptor subtype|nsubj|Upregulation subtype|dobj|END_ENTITY	Upregulation of metabotropic glutamate receptor subtype mGluR3 and mGluR5 in reactive astrocytes in a rat model of mesial temporal_lobe_epilepsy .
12786977	0	glutamate	113,122	mGluR3	34,40	glutamate	mGluR3	CHEBI:29987	53623(Tax:10090)	Chemical	Gene	proteins|amod|START_ENTITY regulation|nmod|proteins role|dep|regulation role|nmod|END_ENTITY	Expression and functional role of mGluR3 and mGluR5 in human astrocytes and glioma cells : opposite regulation of glutamate transporter proteins .
15178451	0	glutamate	78,87	mGluR3	47,53	glutamate	mGluR3	CHEBI:29987	53623(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY subtype|nmod|receptor subtype|amod|END_ENTITY	Expression of a truncated secreted form of the mGluR3 subtype of metabotropic glutamate receptor .
16760467	0	glutamate	17,26	mGluR3	55,61	glutamate	mGluR3	CHEBI:29987	53623(Tax:10090)	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	The metabotropic glutamate G-protein-coupled receptors mGluR3 and mGluR1a are voltage-sensitive .
16845489	0	glutamate	30,39	mGluR3	52,58	glutamate	mGluR3	CHEBI:29987	53623(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|receptor receptor|appos|END_ENTITY	Up-regulation of Metabotropic glutamate receptor 3 -LRB- mGluR3 -RRB- in rat fibrosis and cirrhosis model of persistent hypoxic condition .
8227517	0	glutamate	44,53	mGluR3	64,70	glutamate	mGluR3	CHEBI:29987	53623(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Distribution of the mRNA for a metabotropic glutamate receptor -LRB- mGluR3 -RRB- in the rat brain : an in situ hybridization study .
10187777	0	glutamate	82,91	mGluR4	51,57	glutamate	mGluR4	CHEBI:29987	14802(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY subtype|nmod|receptor subtype|amod|END_ENTITY	Ligand binding to the amino-terminal domain of the mGluR4 subtype of metabotropic glutamate receptor .
10530816	0	glutamate	9,18	mGluR4	91,97	glutamate	mGluR4	CHEBI:29987	14802(Tax:10090)	Chemical	Gene	START_ENTITY|dep|features features|nmod|site site|amod|END_ENTITY	Extended glutamate activates metabotropic receptor types 1 , 2 and 4 : selective features at mGluR4 binding site .
10559233	0	glutamate	72,81	mGluR4	41,47	glutamate	mGluR4	CHEBI:29987	14802(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY subtype|nmod|receptor subtype|amod|END_ENTITY	Probing the ligand-binding domain of the mGluR4 subtype of metabotropic glutamate receptor .
11525421	0	glutamate	39,48	mGluR4	58,64	glutamate	mGluR4	CHEBI:29987	14802(Tax:10090)	Chemical	Gene	screening|nmod|START_ENTITY receptor|nsubj|screening receptor|dobj|gene gene|amod|END_ENTITY	Mutation screening of the metabotropic glutamate receptor mGluR4 -LRB- GRM4 -RRB- gene in patients with schizophrenia .
15217955	6	glutamate	828,837	mGluR4	850,856	glutamate	mGluR4	CHEBI:29987	14802(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	RESULTS : 5-FU-resistant human colon_cancer cells were found to overexpress metabotropic glutamate receptor 4 -LRB- mGluR4 -RRB- .
15589052	0	glutamate	46,55	mGluR4	66,72	glutamate	mGluR4	CHEBI:29987	14802(Tax:10090)	Chemical	Gene	patterns|nmod|START_ENTITY receptors|nsubj|patterns receptors|dobj|END_ENTITY	Expression patterns of Group III metabotropic glutamate receptors mGluR4 and mGluR8 in multiple_sclerosis_lesions .
18266929	0	glutamate	81,90	mGluR4	128,134	glutamate	mGluR4	CHEBI:29987	14802(Tax:10090)	Chemical	Gene	synapse|nmod|START_ENTITY receptors|amod|synapse transmission|nmod|receptors Depression|nmod|transmission provided|nsubjpass|Depression provided|nmod|END_ENTITY	Depression of excitatory transmission at PF-PC synapse by group III metabotropic glutamate receptors is provided exclusively by mGluR4 in the rodent_cerebellar_cortex .
18625254	0	glutamate	13,22	mGluR4	33,39	glutamate	mGluR4	CHEBI:29987	14802(Tax:10090)	Chemical	Gene	START_ENTITY|ccomp|regulate regulate|nsubj|END_ENTITY	Metabotropic glutamate receptors mGluR4 and mGluR8 regulate transmission in the lateral olfactory tract-piriform cortex synapse .
18793851	0	glutamate	51,60	mGluR4	147,153	glutamate	mGluR4	CHEBI:29987	14802(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY modulators|nmod|receptor modulators|dep|Discovery Discovery|nmod|pyrimidines pyrimidines|nmod|modulators modulators|amod|END_ENTITY	Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 -LRB- mGluR4 -RRB- : Part I. Discovery of pyrazolo -LSB- 3,4-d -RSB- pyrimidines as novel mGluR4 positive allosteric modulators .
18793851	0	glutamate	51,60	mGluR4	81,87	glutamate	mGluR4	CHEBI:29987	14802(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 -LRB- mGluR4 -RRB- : Part I. Discovery of pyrazolo -LSB- 3,4-d -RSB- pyrimidines as novel mGluR4 positive allosteric modulators .
19097893	0	glutamate	51,60	mGluR4	81,87	glutamate	mGluR4	CHEBI:29987	14802(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY modulators|nmod|receptor subtype|nsubj|modulators subtype|dobj|4 4|appos|END_ENTITY	Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 -LRB- mGluR4 -RRB- .
19469556	0	glutamate	101,110	mGluR4	123,129	glutamate	mGluR4	CHEBI:29987	14802(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|modulators modulators|amod|4 4|dep|END_ENTITY	Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 -LRB- mGluR4 -RRB- positive allosteric modulators -LRB- PAMs -RRB- .
19640716	0	glutamate	85,94	mGluR4	107,113	glutamate	mGluR4	CHEBI:29987	14802(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|receptor receptor|appos|END_ENTITY	Synthesis and SAR of a novel positive allosteric modulator -LRB- PAM -RRB- of the metabotropic glutamate receptor 4 -LRB- mGluR4 -RRB- .
22008743	0	glutamate	24,33	mGluR4	113,119	glutamate	mGluR4	CHEBI:29987	14802(Tax:10090)	Chemical	Gene	responses|acl|START_ENTITY implicate|nsubj|responses implicate|dobj|involvement involvement|nmod|END_ENTITY	Behavioral responses to glutamate receptor agonists and antagonists implicate the involvement of brain-expressed mGluR4 and mGluR1 in taste transduction for umami in mice .
22468956	0	glutamate	54,63	mGluR4	76,82	glutamate	mGluR4	CHEBI:29987	14802(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Recent advances in the drug discovery of metabotropic glutamate receptor 4 -LRB- mGluR4 -RRB- activators for the treatment of CNS and non-CNS_disorders .
22528491	0	glutamate	32,41	mGluR4	54,60	glutamate	mGluR4	CHEBI:29987	14802(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Native presynaptic metabotropic glutamate receptor 4 -LRB- mGluR4 -RRB- interacts with exocytosis proteins in rat cerebellum .
22570379	0	glutamate	76,85	mGluR4	97,103	glutamate	mGluR4	D018698	14802(Tax:10090)	Chemical	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	A new signalling pathway for parallel fibre presynaptic type 4 metabotropic glutamate receptors -LRB- mGluR4 -RRB- in the rat cerebellar cortex .
26707390	0	glutamate	180,189	mGluR4	210,216	glutamate	mGluR4	D018698	14802(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Radiosynthesis and evaluation of 5-methyl-N - -LRB- 4 - -LSB- -LRB- 11 -RRB- C -RSB- methylpyrimidin-2-yl -RRB- -4 - -LRB- 1H-pyrazol-4-yl -RRB- thiazol-2-amine -LRB- -LSB- -LRB- 11 -RRB- C -RSB- ADX88178 -RRB- as a novel radioligand for imaging of metabotropic glutamate receptor subtype 4 -LRB- mGluR4 -RRB- .
8035186	0	glutamate	24,33	mGluR4	126,132	glutamate	mGluR4	CHEBI:29987	14802(Tax:10090)	Chemical	Gene	levels|compound|START_ENTITY Changes|nmod|levels Changes|dep|increase increase|nmod|subtype subtype|appos|END_ENTITY	Changes in metabotropic glutamate receptor mRNA levels following global ischemia : increase of a putative presynaptic subtype -LRB- mGluR4 -RRB- in highly vulnerable rat brain areas .
8084499	0	glutamate	52,61	mGluR4	73,79	glutamate	mGluR4	CHEBI:29987	14802(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY mRNAs|nmod|receptors Expression|nmod|mRNAs Expression|dep|END_ENTITY	Expression of mRNAs of L-AP4-sensitive metabotropic glutamate receptors -LRB- mGluR4 , mGluR6 , mGluR7 -RRB- in the rat retina .
8801249	0	glutamate	84,93	mGluR4	105,111	glutamate	mGluR4	CHEBI:29987	14802(Tax:10090)	Chemical	Gene	START_ENTITY|dep|receptors receptors|nummod|END_ENTITY	Distributions of the mRNAs for L-2-amino-4-phosphonobutyrate-sensitive metabotropic glutamate receptors , mGluR4 and mGluR7 , in the rat brain .
8815915	0	glutamate	113,122	mGluR4	82,88	glutamate	mGluR4	CHEBI:29987	14802(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY subtype|nmod|receptor subtype|amod|END_ENTITY	Impaired cerebellar synaptic plasticity and motor performance in mice lacking the mGluR4 subtype of metabotropic glutamate receptor .
9676970	0	glutamate	87,96	mGluR4	56,62	glutamate	mGluR4	CHEBI:29987	14802(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY subtype|nmod|receptor subtype|amod|END_ENTITY	Altered spatial_learning_and_memory in mice lacking the mGluR4 subtype of metabotropic glutamate receptor .
10090675	0	glutamate	34,43	mGluR5	56,62	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|receptor receptor|appos|END_ENTITY	The up-regulation of metabotropic glutamate receptor 5 -LRB- mGluR5 -RRB- in Down 's _ syndrome brains .
10594924	0	glutamate	13,22	mGluR5	102,108	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|dep|changes changes|nmod|expression expression|amod|END_ENTITY	Metabotropic glutamate receptors in acutely isolated hippocampal astrocytes : developmental changes of mGluR5 mRNA and functional expression .
10728883	0	glutamate	58,67	mGluR5	38,44	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	activation|amod|START_ENTITY activation|nummod|END_ENTITY	Mobilisation of intracellular Ca2 + by mGluR5 metabotropic glutamate receptor activation in neonatal rat cultured dorsal root ganglia neurones .
10736377	6	glutamate	898,907	mGluR5	1031,1037	glutamate	mGluR8	CHEBI:29987	14823(Tax:10090)	Chemical	Gene	receptors|nsubj|START_ENTITY receptors|xcomp|containing containing|dobj|proteins proteins|dep|I I|dep|mGluR1 mGluR1|appos|END_ENTITY	The metabotropic glutamate receptors fall into the following three groups , each containing two or more individual receptor proteins : group I -LRB- mGluR1 , mGluR5 -RRB- , group II -LRB- mGluR2 , mGluR3 -RRB- , and group III -LRB- mGluR4 , mGluR6 , mGluR7 and mGluR8 -RRB- .
11414786	0	glutamate	86,95	mGluR5	108,114	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Bidirectional regulation of neurite elaboration by alternatively spliced metabotropic glutamate receptor 5 -LRB- mGluR5 -RRB- isoforms .
11543761	0	glutamate	29,38	mGluR5	59,65	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Blockade of the metabotropic glutamate receptor subtype 5 -LRB- mGluR5 -RRB- produces antiparkinsonian-like effects in rats .
12077217	0	glutamate	25,34	mGluR5	44,50	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	START_ENTITY|ccomp|required required|nsubjpass|END_ENTITY	The group I metabotropic glutamate receptor mGluR5 is required for fear memory formation and long-term potentiation in the lateral amygdala .
12763091	0	glutamate	21,30	mGluR5	51,57	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY Role|nmod|receptor subtype|nsubj|Role subtype|dobj|5 5|appos|END_ENTITY	Role of metabotropic glutamate receptor subtype 5 -LRB- mGluR5 -RRB- in the maintenance of cold_hypersensitivity following a peripheral_mononeuropathy in the rat .
15312183	0	glutamate	59,68	mGluR5	81,87	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Permissive role of adenosine A2A receptors on metabotropic glutamate receptor 5 -LRB- mGluR5 -RRB- - mediated effects in the striatum .
15703249	0	glutamate	17,26	mGluR5	37,43	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	The metabotropic glutamate receptor , mGluR5 , is a key determinant of good and bad spatial learning performance and hippocampal synaptic plasticity .
15878659	0	glutamate	43,52	mGluR5	65,71	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|receptor receptor|appos|END_ENTITY	Non-competitive inhibitors of metabotropic glutamate receptor 5 -LRB- mGluR5 -RRB- .
15919101	0	glutamate	53,62	mGluR5	83,89	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	MTEP , a new selective antagonist of the metabotropic glutamate receptor subtype 5 -LRB- mGluR5 -RRB- , produces antiparkinsonian-like effects in rats .
16023685	0	glutamate	13,22	mGluR5	33,39	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Metabotropic glutamate receptor -LRB- mGluR5 -RRB- antagonist MPEP attenuated cue - and schedule-induced reinstatement of nicotine self-administration behavior in rats .
16153770	0	glutamate	57,66	mGluR5	88,94	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY studies|nmod|receptor antagonist|nmod|studies antagonist|nsubj|5 5|appos|END_ENTITY	In vitro metabolic studies on the selective metabotropic glutamate receptor sub-type 5 -LRB- mGluR5 -RRB- antagonist 3 - -LSB- -LRB- 2-methyl-1 ,3 - thiazol-4-yl -RRB- _ ethynyl -RSB- - pyridine -LRB- MTEP -RRB- .
16178729	0	glutamate	60,69	mGluR5	90,96	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY modulators|nmod|receptor Discovery|nmod|modulators subtype|nsubj|Discovery subtype|dobj|5 5|appos|END_ENTITY	Discovery of positive allosteric modulators of metabotropic glutamate receptor subtype 5 -LRB- mGluR5 -RRB- .
16289868	0	glutamate	37,46	mGluR5	30,36	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Prolonged blockade of NMDA or mGluR5 glutamate receptors reduces nigrostriatal_degeneration while inducing selective metabolic changes in the basal ganglia circuitry in a rodent model of Parkinson 's _ disease .
16837196	0	glutamate	122,131	mGluR5	144,150	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|receptor receptor|appos|END_ENTITY	Structure-activity relationships for the linker in a series of pyridinyl-alkynes that are antagonists of the metabotropic glutamate receptor 5 -LRB- mGluR5 -RRB- .
16839764	0	glutamate	69,78	mGluR5	91,97	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|receptor receptor|appos|END_ENTITY	A new series of pyridinyl-alkynes as antagonists of the metabotropic glutamate receptor 5 -LRB- mGluR5 -RRB- .
17353071	0	glutamate	20,29	mGluR5	0,6	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|metabotropic metabotropic|amod|END_ENTITY	mGluR5 metabotropic glutamate receptors and dyskinesias in MPTP monkeys .
17634364	0	glutamate	21,30	mGluR5	93,99	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|depression depression|nmod|downregulation downregulation|nmod|END_ENTITY	Loss of metabotropic glutamate receptor-dependent long-term depression via downregulation of mGluR5 after status_epilepticus .
17944877	0	glutamate	28,37	mGluR5	8,14	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|nummod|END_ENTITY	Group I mGluR5 metabotropic glutamate receptors regulate proliferation of neuronal progenitors in specific forebrain developmental domains .
18046312	0	glutamate	13,22	mGluR5	35,41	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	START_ENTITY|ccomp|antagonists antagonists|dep|END_ENTITY	Metabotropic glutamate 5 receptor -LRB- mGluR5 -RRB- antagonists decrease nicotine seeking , but do not affect the reinforcement enhancing effects of nicotine .
18377703	0	glutamate	13,22	mGluR5	35,41	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	regulation|compound|START_ENTITY regulation|compound|END_ENTITY	Metabotropic glutamate receptor 5 -LRB- mGluR5 -RRB- regulation of ethanol sedation , dependence and consumption : relationship to acamprosate actions .
18501638	0	glutamate	33,42	mGluR5	60,66	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Enhanced binding of metabotropic glutamate receptor type 5 -LRB- mGluR5 -RRB- PET tracers in the brain of parkinsonian primates .
18784306	0	glutamate	21,30	mGluR5	43,49	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	antagonism|amod|START_ENTITY antagonism|compound|END_ENTITY	In vivo metabotropic glutamate receptor 5 -LRB- mGluR5 -RRB- antagonism prevents cocaine-induced disruption of postsynaptically maintained mGluR5-dependent long-term depression .
19463707	0	glutamate	13,22	mGluR5	35,41	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|reinstatement reinstatement|appos|END_ENTITY	Metabotropic glutamate receptor 5 -LRB- mGluR5 -RRB- antagonists attenuate cocaine priming - and cue-induced reinstatement of cocaine seeking .
19660528	0	glutamate	13,22	mGluR5	23,29	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	START_ENTITY|ccomp|opposes opposes|nsubj|blockade blockade|amod|END_ENTITY	Metabotropic glutamate mGluR5 receptor blockade opposes abnormal_involuntary_movements and the increases in glutamic_acid decarboxylase mRNA levels induced by l-DOPA in striatal neurons of 6-hydroxydopamine-lesioned rats .
19672584	0	glutamate	80,89	mGluR5	100,106	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Synaptic plasticity in the adult visual cortex is regulated by the metabotropic glutamate receptor , mGluR5 .
19840937	0	glutamate	27,36	mGluR5	49,55	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Intracellular metabotropic glutamate receptor 5 -LRB- mGluR5 -RRB- activates signaling cascades distinct from cell surface counterparts .
20414370	10	glutamate	1727,1736	mGluR5	1720,1726	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	response|compound|START_ENTITY response|amod|END_ENTITY	These results represent an enrichment factor of 23 for pure potentiation of the mGluR5 glutamate response and 30 for overall mGluR5 modulation activity when compared with those of the original mGluR5 experimental screening data -LRB- 0.94 % hit rate -RRB- .
20505551	0	glutamate	17,26	mGluR5	27,33	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	intake|amod|START_ENTITY intake|amod|END_ENTITY	The metabotropic glutamate mGluR5 receptor agonist CHPG stimulates food intake .
20583985	0	glutamate	49,58	mGluR5	79,85	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY imaging|nmod|receptor Radioligands|nmod|imaging subtype|nsubj|Radioligands subtype|dobj|5 5|appos|END_ENTITY	Radioligands for the PET imaging of metabotropic glutamate receptor subtype 5 -LRB- mGluR5 -RRB- .
20709161	0	glutamate	54,63	mGluR5	74,80	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Membrane estrogen receptors activate the metabotropic glutamate receptors mGluR5 and mGluR3 to bidirectionally regulate CREB phosphorylation in female rat striatal neurons .
20720114	0	glutamate	82,91	mGluR5	75,81	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	The scaffold protein NHERF2 determines the coupling of P2Y1 nucleotide and mGluR5 glutamate receptor to different ion channels in neurons .
20854878	0	glutamate	34,43	mGluR5	44,50	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|elimination elimination|amod|END_ENTITY	Protective effect of metabotropic glutamate mGluR5 receptor elimination in a 6-hydroxydopamine model of Parkinson 's _ disease .
21152045	0	glutamate	48,57	mGluR5	70,76	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Operant sensation seeking requires metabotropic glutamate receptor 5 -LRB- mGluR5 -RRB- .
21161716	0	glutamate	110,119	mGluR5	131,137	glutamate	mGluR5	D018698	14805(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Pharmacological characterization of MRZ-8676 , a novel negative allosteric modulator of subtype 5 metabotropic glutamate receptors -LRB- mGluR5 -RRB- : focus on L : _ - DOPA-induced_dyskinesia .
21368721	0	glutamate	54,63	mGluR5	75,81	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Positive allosteric modulators of type 5 metabotropic glutamate receptors -LRB- mGluR5 -RRB- and their therapeutic potential for the treatment of CNS_disorders .
21406237	0	glutamate	95,104	mGluR5	125,131	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY subtype|nsubj|receptor subtype|dobj|5 5|appos|END_ENTITY	In vitro and in vivo evaluation of -LSB- 18F -RSB- - FDEGPECO as a PET tracer for imaging the metabotropic glutamate receptor subtype 5 -LRB- mGluR5 -RRB- .
21896768	0	glutamate	31,40	mGluR5	53,59	glutamate	mGluR5	D018698	14805(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY Expression|nmod|receptor Expression|appos|END_ENTITY	Expression of the metabotropic glutamate receptor 5 -LRB- mGluR5 -RRB- induces melanoma in transgenic_mice .
22238580	0	glutamate	54,63	mGluR5	47,53	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Successful cognitive aging in rats : a role for mGluR5 glutamate receptors , homer_1 proteins and downstream signaling pathways .
22358084	0	glutamate	32,41	mGluR5	99,105	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	transmission|compound|START_ENTITY rat|dobj|transmission rat|nmod|END_ENTITY	GET73 modulates rat hippocampal glutamate transmission : evidence for a functional interaction with mGluR5 .
22449017	0	glutamate	13,22	mGluR5	35,41	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Metabotropic glutamate receptor 5 -LRB- mGluR5 -RRB- regulates bladder_nociception .
22612431	0	glutamate	13,22	mGluR5	34,40	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Metabotropic glutamate receptors -LRB- mGluR5 -RRB- activate transient receptor potential canonical channels to improve the regularity of the respiratory rhythm generated by the pre-B tzinger complex in mice .
22613149	0	glutamate	74,83	mGluR5	104,110	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Development of -LSB- -LRB- 18 -RRB- F -RSB- - PSS223 as a PET tracer for imaging of metabotropic glutamate receptor subtype 5 -LRB- mGluR5 -RRB- .
22860171	0	glutamate	67,76	mGluR5	97,103	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY modulators|nmod|receptor Progress|nmod|modulators subtype|nsubj|Progress subtype|dobj|5 5|appos|END_ENTITY	Progress toward positive allosteric modulators of the metabotropic glutamate receptor subtype 5 -LRB- mGluR5 -RRB- .
22995293	0	glutamate	59,68	mGluR5	81,87	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Constitutive internalization and recycling of metabotropic glutamate receptor 5 -LRB- mGluR5 -RRB- .
23133800	0	glutamate	28,37	mGluR5	58,64	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY imaging|nmod|receptor subtype|nsubj|imaging subtype|dobj|5 5|appos|END_ENTITY	PET imaging of metabotropic glutamate receptor subtype 5 -LRB- mGluR5 -RRB- .
23165119	0	glutamate	13,22	mGluR5	35,41	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Metabotropic glutamate receptor 5 -LRB- mGluR5 -RRB- regulates proliferation and differentiation of neuronal progenitors in the developmental hippocampus .
23396537	0	glutamate	76,85	mGluR5	59,65	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|down-regulation down-regulation|nmod|underlies underlies|amod|END_ENTITY	Astroglial FMRP-dependent translational down-regulation of mGluR5 underlies glutamate transporter GLT1 dysregulation in the fragile_X mouse .
23775850	0	glutamate	47,56	mGluR5	80,86	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	mavoglurant|amod|START_ENTITY mavoglurant|amod|antagonist antagonist|dep|END_ENTITY	Metabolism and disposition of the metabotropic glutamate receptor 5 antagonist -LRB- mGluR5 -RRB- mavoglurant -LRB- AFQ056 -RRB- in healthy subjects .
23804486	0	glutamate	32,41	mGluR5	59,65	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Distinct increased metabotropic glutamate receptor type 5 -LRB- mGluR5 -RRB- in temporal_lobe_epilepsy with and without hippocampal_sclerosis .
24168364	0	glutamate	54,63	mGluR5	76,82	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Positive allosteric modulators -LRB- PAMs -RRB- of metabotropic glutamate receptor 5 -LRB- mGluR5 -RRB- attenuate microglial activation .
24232444	0	glutamate	57,66	mGluR5	79,85	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|compound|END_ENTITY	Fragile_X_syndrome : a preclinical review on metabotropic glutamate receptor 5 -LRB- mGluR5 -RRB- antagonists and drug development .
24358885	0	glutamate	59,68	mGluR5	81,87	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Positive or negative allosteric modulation of metabotropic glutamate receptor 5 -LRB- mGluR5 -RRB- does not alter expression of behavioral sensitization to methamphetamine .
24392688	0	glutamate	198,207	mGluR5	220,226	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|dep|allosteric allosteric|compound|END_ENTITY	Discovery and preclinical characterization of 1-methyl-3 - -LRB- 4-methylpyridin-3-yl -RRB- -6 - -LRB- pyridin-2-ylmethoxy -RRB- -1 H-pyrazolo - -LSB- 3,4-b -RSB- pyrazine -LRB- PF470 -RRB- : a highly potent , selective , and efficacious metabotropic glutamate receptor 5 -LRB- mGluR5 -RRB- negative allosteric modulator .
25305528	0	glutamate	32,41	mGluR5	54,60	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	F|amod|START_ENTITY F|appos|END_ENTITY	Preparation of the metabotropic glutamate receptor 5 -LRB- mGluR5 -RRB- PET tracer -LSB- -LRB- 18 -RRB- F -RSB- FPEB for human use : An automated radiosynthesis and a novel one-pot synthesis of its radiolabeling precursor .
25323624	0	glutamate	63,72	mGluR5	84,90	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Negative versus positive allosteric modulation of metabotropic glutamate receptors -LRB- mGluR5 -RRB- : indices for potential pro-cognitive drug properties based on EEG network oscillations and sleep-wake organization in rats .
25591476	0	glutamate	30,39	mGluR5	131,137	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY Relevance|nmod|receptor Relevance|dep|Evidence Evidence|nmod|mice mice|amod|END_ENTITY	Relevance of the metabotropic glutamate receptor -LRB- mGluR5 -RRB- in the regulation of NREM-REM sleep cycle and homeostasis : Evidence from mGluR5 -LRB- - / - -RRB- mice .
25591476	0	glutamate	30,39	mGluR5	50,56	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Relevance of the metabotropic glutamate receptor -LRB- mGluR5 -RRB- in the regulation of NREM-REM sleep cycle and homeostasis : Evidence from mGluR5 -LRB- - / - -RRB- mice .
26598462	0	glutamate	105,114	mGluR5	84,90	glutamate	mGluR5	D018698	14805(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY antagonists|dep|receptor antagonists|amod|END_ENTITY	Synthesis and biological evaluation of picolinamides and thiazole-2-carboxamides as mGluR5 -LRB- metabotropic glutamate receptor 5 -RRB- antagonists .
26826734	0	glutamate	72,81	mGluR5	94,100	glutamate	mGluR5	D018698	14805(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Computer-aided design of negative allosteric modulators of metabotropic glutamate receptor 5 -LRB- mGluR5 -RRB- : Comparative molecular field analysis of aryl_ether derivatives .
7782501	0	glutamate	47,56	mGluR5	27,33	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|expression expression|nmod|metabotropic metabotropic|amod|END_ENTITY	Differential expression of mGluR5 metabotropic glutamate receptor mRNA by rat striatal neurons .
8295733	0	glutamate	51,60	mGluR5	71,77	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Immunohistochemical localization of a metabotropic glutamate receptor , mGluR5 , in the rat brain .
9152368	0	glutamate	66,75	mGluR5	50,56	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	toxicity|amod|START_ENTITY prevents|dobj|toxicity prevents|nsubj|Activation Activation|nmod|END_ENTITY	Activation of the metabotropic glutamate receptor mGluR5 prevents glutamate toxicity in primary cultures of cerebellar neurons .
9179880	0	glutamate	20,29	mGluR5	0,6	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	distribution|amod|START_ENTITY distribution|nummod|END_ENTITY	mGluR5 metabotropic glutamate receptor distribution in rat and human spinal cord : a developmental study .
9197273	0	glutamate	33,42	mGluR5	60,66	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY Distribution|nmod|receptor subtype|nsubj|Distribution subtype|dobj|END_ENTITY	Distribution of the metabotropic glutamate receptor subtype mGluR5 in rat midbrain periaqueductal grey and relationship with ascending spinofugal afferents .
9242710	0	glutamate	59,68	mGluR5	89,95	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Phosphorylation and calmodulin binding of the metabotropic glutamate receptor subtype 5 -LRB- mGluR5 -RRB- are antagonistic in vitro .
9302110	0	glutamate	68,77	mGluR5	48,54	glutamate	mGluR5	CHEBI:29987	14805(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Light and electron microscopic demonstration of mGluR5 metabotropic glutamate receptor immunoreactive neuronal elements in the rat cerebellar cortex .
8084499	0	glutamate	52,61	mGluR6	81,87	glutamate	mGluR6	CHEBI:29987	14806(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY mRNAs|nmod|receptors Expression|nmod|mRNAs Expression|dep|mGluR4 mGluR4|appos|END_ENTITY	Expression of mRNAs of L-AP4-sensitive metabotropic glutamate receptors -LRB- mGluR4 , mGluR6 , mGluR7 -RRB- in the rat retina .
12021391	0	glutamate	67,76	mGluR7	144,150	glutamate	mGluR7	CHEBI:29987	14807(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY regulation|nmod|receptor Dissociation|nmod|regulation interactions|nsubj|Dissociation interactions|nmod|calmodulin calmodulin|nmod|function function|amod|END_ENTITY	Dissociation of protein kinase-mediated regulation of metabotropic glutamate receptor 7 -LRB- mGluR7 -RRB- interactions with calmodulin and regulation of mGluR7 function .
12021391	0	glutamate	67,76	mGluR7	89,95	glutamate	mGluR7	CHEBI:29987	14807(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Dissociation of protein kinase-mediated regulation of metabotropic glutamate receptor 7 -LRB- mGluR7 -RRB- interactions with calmodulin and regulation of mGluR7 function .
17650109	0	glutamate	16,25	mGluR7	0,6	glutamate	mGluR7	CHEBI:29987	14807(Tax:10090)	Chemical	Gene	release|amod|START_ENTITY inhibits|dobj|release inhibits|nsubj|END_ENTITY	mGluR7 inhibits glutamate release through a PKC-independent decrease in the activity of P/Q-type Ca2 + channels and by diminishing cAMP in hippocampal nerve terminals .
18155073	0	glutamate	17,26	mGluR7	39,45	glutamate	mGluR7	CHEBI:29987	14807(Tax:10090)	Chemical	Gene	agonist|amod|START_ENTITY agonist|compound|END_ENTITY	The metabotropic glutamate receptor 7 -LRB- mGluR7 -RRB- allosteric agonist AMN082 modulates nucleus accumbens GABA and glutamate , but not dopamine , in rats .
18329248	0	glutamate	35,44	mGluR7	54,60	glutamate	mGluR7	CHEBI:29987	14807(Tax:10090)	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	A polymorphism of the metabotropic glutamate receptor mGluR7 -LRB- GRM7 -RRB- gene is associated with schizophrenia .
22056957	0	glutamate	30,39	mGluR7	52,58	glutamate	mGluR7	CHEBI:29987	14807(Tax:10090)	Chemical	Gene	START_ENTITY|acl|receptor receptor|dobj|END_ENTITY	The pre-synaptic metabotropic glutamate receptor 7 `` mGluR7 '' is a critical modulator of ethanol sensitivity in mice .
23612982	0	glutamate	27,36	mGluR7	49,55	glutamate	mGluR7	D018698	14807(Tax:10090)	Chemical	Gene	internalization|compound|START_ENTITY internalization|compound|END_ENTITY	Regulation of metabotropic glutamate receptor 7 -LRB- mGluR7 -RRB- internalization and surface expression by Ser/Thr protein phosphatase 1 .
26022263	0	glutamate	13,22	mGluR7	35,41	glutamate	mGluR7	D018698	14807(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|receptor receptor|appos|END_ENTITY	Metabotropic glutamate receptor 7 -LRB- mGluR7 -RRB- as a target for the treatment of psychostimulant_dependence .
26022263	0	glutamate	13,22	mGluR7	35,41	glutamate	mGluR7	D018698	14807(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|receptor receptor|appos|END_ENTITY	Metabotropic glutamate receptor 7 -LRB- mGluR7 -RRB- as a target for the treatment of psychostimulant_dependence .
8084499	0	glutamate	52,61	mGluR7	89,95	glutamate	mGluR7	CHEBI:29987	14807(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY mRNAs|nmod|receptors Expression|nmod|mRNAs Expression|dep|mGluR4 mGluR4|appos|END_ENTITY	Expression of mRNAs of L-AP4-sensitive metabotropic glutamate receptors -LRB- mGluR4 , mGluR6 , mGluR7 -RRB- in the rat retina .
8764662	0	glutamate	45,54	mGluR7	65,71	glutamate	mGluR7	CHEBI:29987	14807(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Compartmental localization of a metabotropic glutamate receptor -LRB- mGluR7 -RRB- : two different active sites at a retinal synapse .
8787837	0	glutamate	43,52	mGluR7	63,69	glutamate	mGluR7	CHEBI:29987	14807(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Presynaptic localization of a metabotropic glutamate receptor , mGluR7 , in the primary afferent neurons : an immunohistochemical study in the rat .
8929965	0	glutamate	51,60	mGluR7	71,77	glutamate	mGluR7	CHEBI:29987	14807(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Immunohistochemical localization of a metabotropic glutamate receptor , mGluR7 , in ganglion neurons of the rat ; with special reference to the presence in glutamatergic ganglion neurons .
9080455	0	glutamate	31,40	mGluR7	51,57	glutamate	mGluR7	CHEBI:29987	14807(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY Localization|nmod|receptor Localization|appos|END_ENTITY	Localization of a metabotropic glutamate receptor , mGluR7 , in axon terminals of presumed nociceptive , primary afferent fibers in the superficial layers of the spinal dorsal horn : an electron microscope study in the rat .
8710211	0	glutamate	43,52	mGluR8	63,69	glutamate	mGluR8	CHEBI:29987	14823(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Presynaptic localization of a metabotropic glutamate receptor , mGluR8 , in the rhinencephalic areas : a light and electron microscope study in the rat .
11912074	0	glutamate	36,45	mGlur7	65,71	glutamate	mGlur7	CHEBI:29987	14807(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|receptors receptors|dep|END_ENTITY	No association between metabotropic glutamate receptors 7 and 8 -LRB- mGlur7 and mGlur8 -RRB- gene polymorphisms and withdrawal seizures and delirium tremens in alcohol-dependent individuals .
21903115	0	glutamate	118,127	mammalian_target_of_rapamycin	19,48	glutamate	mammalian target of rapamycin	CHEBI:29987	2475	Chemical	Gene	START_ENTITY|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of the mammalian_target_of_rapamycin signaling in the antidepressant-like effect of group II metabotropic glutamate receptor antagonists .
22652059	0	glutamate	95,104	mgl-2	76,81	glutamate	mgl-2	CHEBI:29987	172914(Tax:6239)	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Orthosteric and allosteric drug binding sites in the Caenorhabditis_elegans mgl-2 metabotropic glutamate receptor .
26420356	0	glutamate	130,139	miR-107	122,129	glutamate	miR-107	D018698	100314022(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	Beneficial effect of magnesium_lithospermate_B on cerebral_ischemia-reperfusion injury in rats involves the regulation of miR-107 / glutamate transporter 1 pathway .
18840757	10	glutamate	1508,1517	mice	1502,1506	glutamate	Narp	CHEBI:29987	53324(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY END_ENTITY|appos|receptor	Consistent with reduced AMPA responsiveness after chronic cocaine in Narp KO mice , glutamate receptor 1 was reduced in the PSD fraction of Narp KO mice withdrawn from cocaine .
27093227	7	glutamate	1442,1451	mice	1483,1487	glutamate	AgRP	D018698	11604(Tax:10090)	Chemical	Gene	release|compound|START_ENTITY indicative|nmod|release indicative|nmod|END_ENTITY	Paired-pulse , photo-stimulation revealed paired-pulse_depression , which is indicative of greater glutamate release , in the castrated male mice compared to gonad-intact male mice .
11103516	0	glutamate	71,80	neurokinin_1_receptor	34,55	glutamate	neurokinin 1 receptor	CHEBI:29987	24807(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY END_ENTITY|nmod|receptors	Comparison of localization of the neurokinin_1_receptor with AMPA-type glutamate receptors in the rat spinal cord .
7577724	0	glutamate	43,52	ornithine_decarboxylase	62,85	glutamate	ornithine decarboxylase	CHEBI:29987	24609(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|activity activity|amod|END_ENTITY	Time-dependent effects of dexamethasone on glutamate binding , ornithine_decarboxylase activity and polyamine levels in the transected spinal cord .
12558976	0	glutamate	107,116	p38	39,42	glutamate	p38	CHEBI:29987	81649(Tax:10116)	Chemical	Gene	excitotoxicity|amod|START_ENTITY roles|nmod|excitotoxicity Regulation|dep|roles Regulation|nmod|kinase kinase|amod|END_ENTITY	Regulation of c-Jun_N-terminal_kinase , p38 kinase and AP-1 DNA binding in cultured brain neurons : roles in glutamate excitotoxicity and lithium neuroprotection .
9426307	0	glutamate	71,80	p53	52,55	glutamate	p53	CHEBI:29987	22060(Tax:10090)	Chemical	Gene	response|nmod|START_ENTITY END_ENTITY|nmod|response	N18-RE-105 cells : differentiation and activation of p53 in response to glutamate and adriamycin is blocked by SV40 large T antigen tsA58 .
9844018	0	glutamate	13,22	p90rsk	74,80	glutamate	p90rsk	CHEBI:29987	6195	Chemical	Gene	translocation|amod|START_ENTITY translocation|nmod|END_ENTITY	Metabotropic glutamate receptor-initiated translocation of protein kinase p90rsk to polyribosomes : a possible factor regulating synaptic protein synthesis .
26385361	0	glutamate	39,48	pannexin-1	10,20	glutamate	pannexin-1	D018698	24145	Chemical	Gene	release|nmod|START_ENTITY END_ENTITY|nmod|release	Effect of pannexin-1 on the release of glutamate and cytokines in astrocytes .
11092449	0	glutamate	16,25	phospholipase_A2	39,55	glutamate	phospholipase A2	CHEBI:29987	5320	Chemical	Gene	receptors|amod|START_ENTITY receptors|nmod|END_ENTITY	Modification of glutamate receptors by phospholipase_A2 : its role in adaptive neural plasticity .
15383741	0	glutamate	44,53	rEAAC1	66,72	glutamate	rEAAC1	CHEBI:29987	25550(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Rivastigmine as a modulator of the neuronal glutamate transporter rEAAC1 mRNA expression .
16527819	0	glutamate	14,23	serotonin_transporter	66,87	glutamate	serotonin transporter	CHEBI:29987	6532	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	The conserved glutamate -LRB- Glu136 -RRB- in transmembrane domain 2 of the serotonin_transporter is required for the conformational switch in the transport cycle .
22579423	0	glutamate	112,121	sweet-taste_receptor_T1R3	76,101	glutamate	sweet-taste receptor T1R3	CHEBI:29987	83771(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Anticonvulsant activity of artificial sweeteners : a structural link between sweet-taste_receptor_T1R3 and brain glutamate receptors .
7914359	0	glutamate	57,66	transforming_growth_factor-beta_1	20,53	glutamate	transforming growth factor-beta 1	CHEBI:29987	7040	Chemical	Gene	neurotoxicity|amod|START_ENTITY END_ENTITY|nmod|neurotoxicity	Opposing effects of transforming_growth_factor-beta_1 on glutamate neurotoxicity .
26166724	0	glutamate	24,33	transient_receptor_potential_melastatin_8	50,91	glutamate	transient receptor potential melastatin 8	D018698	171382(Tax:10090)	Chemical	Gene	transporters|compound|START_ENTITY transporters|nmod|END_ENTITY	Expression of vesicular glutamate transporters in transient_receptor_potential_melastatin_8 -LRB- TRPM8 -RRB- - positive dental afferents in the mouse .
16123171	0	glutamate	107,116	tumor_necrosis_factor-alpha	160,187	glutamate	tumor necrosis factor-alpha	CHEBI:29987	24835(Tax:10116)	Chemical	Gene	GLAST|compound|START_ENTITY expression|nmod|GLAST inhibit|nmod|expression inhibit|parataxis|mediated mediated|nmod|END_ENTITY	Autoantigen specific T cells inhibit glutamate uptake in astrocytes by decreasing expression of astrocytic glutamate transporter GLAST : a mechanism mediated by tumor_necrosis_factor-alpha .
16123171	0	glutamate	37,46	tumor_necrosis_factor-alpha	160,187	glutamate	tumor necrosis factor-alpha	CHEBI:29987	24835(Tax:10116)	Chemical	Gene	uptake|amod|START_ENTITY inhibit|dobj|uptake inhibit|parataxis|mediated mediated|nmod|END_ENTITY	Autoantigen specific T cells inhibit glutamate uptake in astrocytes by decreasing expression of astrocytic glutamate transporter GLAST : a mechanism mediated by tumor_necrosis_factor-alpha .
16882655	0	glutamate	21,30	tumor_necrosis_factor-alpha	70,97	glutamate	tumor necrosis factor-alpha	CHEBI:29987	21926(Tax:10090)	Chemical	Gene	exocytosis|compound|START_ENTITY exocytosis|dep|control control|nmod|END_ENTITY	P2Y1_receptor-evoked glutamate exocytosis from astrocytes : control by tumor_necrosis_factor-alpha and prostaglandins .
17198691	0	glutamate	49,58	tumor_necrosis_factor-alpha	96,123	glutamate	tumor necrosis factor-alpha	CHEBI:29987	24835(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|nmod|effect effect|nmod|END_ENTITY	Evidence for a role for the group I metabotropic glutamate receptor in the inhibitory effect of tumor_necrosis_factor-alpha on long-term potentiation .
21371514	0	glutamate	61,70	tumor_necrosis_factor-alpha	92,119	glutamate	tumor necrosis factor-alpha	CHEBI:29987	7124	Chemical	Gene	GLT-1|amod|START_ENTITY variants|nmod|GLT-1 splice|dobj|variants splice|nmod|END_ENTITY	Differential regulation of C-terminal splice variants of the glutamate transporter GLT-1 by tumor_necrosis_factor-alpha in primary cultures of astrocytes .
19747495	0	glutamate	22,31	vGluT1	45,51	glutamate	vGluT1	CHEBI:29987	116638(Tax:10116)	Chemical	Gene	transporters|amod|START_ENTITY expression|nmod|transporters END_ENTITY|nsubj|expression	Reduced expression of glutamate transporters vGluT1 , EAAT2 and EAAT4 in learned helpless rats , an animal model of depression .
20335103	0	glutamate	11,20	vascular_endothelial_growth_factor	24,58	glutamate	vascular endothelial growth factor	CHEBI:29987	83785(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|mRNA mRNA|amod|END_ENTITY	-LSB- Effect of glutamate on vascular_endothelial_growth_factor mRNA and protein expressions in hypoxic rat astrocytes in vitro -RSB- .
15936116	0	glutamate	70,79	vesicular_GABA_transporter	24,50	glutamate	vesicular GABA transporter	CHEBI:29987	50676(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Decreased expression of vesicular_GABA_transporter , but not vesicular glutamate , acetylcholine and monoamine transporters in rat brain following focal ischemia .
18371048	0	glutamate_aspartate	25,44	GLAST	58,63	glutamate aspartate	GLAST	null	6507	Chemical	Gene	transporter|amod|START_ENTITY regulation|nmod|transporter regulation|appos|END_ENTITY	Inhibitory regulation of glutamate_aspartate transporter -LRB- GLAST -RRB- expression in astrocytes by cadmium-induced calcium influx .
20070863	0	glutamate_aspartate	30,49	GLAST	62,67	glutamate aspartate	GLAST	null	6507	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Ca -LRB- 2 + -RRB- - dependent reduction of glutamate_aspartate transporter GLAST expression in astrocytes by P2X -LRB- 7 -RRB- _ receptor-mediated phosphoinositide 3-kinase signaling .
22886112	0	glutamate_aspartate	4,23	GLAST	37,42	glutamate aspartate	GLAST	null	6507	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	The glutamate_aspartate transporter -LRB- GLAST -RRB- mediates L-glutamate-stimulated ascorbate-release via swelling-activated anion channels in cultured neonatal rodent astrocytes .
21558310	0	glutamate_cysteine	17,35	Gclm	61,65	glutamate cysteine	Gclm	null	14630(Tax:10090)	Chemical	Gene	subunit|compound|START_ENTITY subunit|appos|END_ENTITY	Lack of maternal glutamate_cysteine ligase modifier subunit -LRB- Gclm -RRB- decreases oocyte glutathione concentrations and disrupts preimplantation development in mice .
21728338	0	glutamate_cysteine	109,127	Nrf2	150,154	glutamate cysteine	Nrf2	null	4780	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Multidrug_resistance-associated_protein_1 mediates 15-deoxy - -LRB- 12,14 -RRB- - prostaglandin_J2-induced expression of glutamate_cysteine ligase expression via Nrf2 signaling in human breast_cancer cells .
24849491	0	glutamate_pyruvate	69,87	GPT	102,105	glutamate pyruvate	GPT	null	2875	Chemical	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	A comparative study of glutamate_oxaloacetate transaminase -LRB- GOT -RRB- and glutamate_pyruvate transaminase -LRB- GPT -RRB- levels in the saliva of diabetic and normal patients .
8098182	0	glutamic_acid	38,51	COL3A1	76,82	glutamic acid	COL3A1	CHEBI:18237	1281	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Single base mutation that substitutes glutamic_acid for glycine 1021 in the COL3A1 gene and causes Ehlers-Danlos_syndrome type IV .
10644995	0	glutamic_acid	61,74	EphB2	41,46	glutamic acid	EphB2	CHEBI:18237	2048	Chemical	Gene	receptor|nmod|START_ENTITY receptor|amod|END_ENTITY	Replacing two conserved tyrosines of the EphB2 receptor with glutamic_acid prevents binding of SH2 domains without abrogating kinase activity and biological responses .
9838159	0	glutamic_acid	79,92	GAD65	113,118	glutamic acid	GAD65	CHEBI:18237	24380(Tax:10116)	Chemical	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Intra-accumbens infusions of antisense oligodeoxynucleotides to one isoform of glutamic_acid decarboxylase mRNA , GAD65 , but not to GAD67 mRNA , impairs sustained attention performance in the rat .
8751281	0	glutamic_acid	28,41	GAD67	57,62	glutamic acid	GAD67	CHEBI:18237	24379(Tax:10116)	Chemical	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Progesterone suppression of glutamic_acid decarboxylase -LRB- GAD67 -RRB- mRNA levels in the preoptic area : correlation to the luteinizing hormone surge .
23376695	0	glutamic_acid	33,46	NAP-22	15,21	glutamic acid	NAP-22	CHEBI:18237	10409	Chemical	Gene	START_ENTITY|nsubj|Interaction Interaction|nmod|END_ENTITY	Interaction of NAP-22 with brain glutamic_acid decarboxylase -LRB- GAD -RRB- .
21704885	0	glutamic_acid	31,44	NEMO	26,30	glutamic acid	NEMO	CHEBI:18237	8517	Chemical	Gene	START_ENTITY|nsubj|alterations alterations|nmod|END_ENTITY	Congenital alterations of NEMO glutamic_acid 223 result in hypohidrotic_ectodermal_dysplasia and immunodeficiency with normal serum IgG levels .
16198348	0	glutamic_acid	43,56	RPE65	106,111	glutamic acid	RPE65	CHEBI:18237	6121	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	Identification of conserved histidines and glutamic_acid as key residues for isomerohydrolase activity of RPE65 , an enzyme of the visual cycle in the retinal pigment epithelium .
20043869	0	glutamic_acid	23,36	RPE65	93,98	glutamic acid	RPE65	CHEBI:18237	6121	Chemical	Gene	residue|amod|START_ENTITY charge|nmod|residue crucial|nsubj|charge crucial|nmod|activity activity|nmod|END_ENTITY	Negative charge of the glutamic_acid 417 residue is crucial for isomerohydrolase activity of RPE65 .
24322328	0	glutamic_acid	31,44	adrenoceptor_b2_surface	65,88	glutamic acid	adrenoceptor b2 surface	CHEBI:18237	154	Chemical	Gene	START_ENTITY|nmod|gene gene|amod|END_ENTITY	Evaluation of the glutamine 27 glutamic_acid polymorphism in the adrenoceptor_b2_surface gene on obesity and metabolic phenotypes in Taiwan .
22036037	0	glutamic_acid	9,22	cannabinoid_1_receptor	68,90	glutamic acid	cannabinoid 1 receptor	CHEBI:18237	12801(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Cortical glutamic_acid decarboxylase 67 deficiency results in lower cannabinoid_1_receptor messenger RNA expression : implications for schizophrenia .
17327402	1	glutamic_acid	82,95	gamma-carboxyglutamic_acid	108,134	glutamic acid	gamma-glutamyl carboxylase	CHEBI:18237	56316(Tax:10090)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	The carboxylation of glutamic_acid residues to gamma-carboxyglutamic_acid -LRB- Gla -RRB- by the vitamin_K-dependent gamma-glutamyl_carboxylase -LRB- gamma-carboxylase -RRB- is an essential posttranslational modification required for the biological activity of a number of proteins , including proteins involved in blood_coagulation and its regulation .
11916141	0	glutamic_acid	84,97	glutamate_carboxypeptidase_II	14,43	glutamic acid	glutamate carboxypeptidase II	CHEBI:18237	2346	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of glutamate_carboxypeptidase_II by phosphonamidothionate derivatives of glutamic_acid .
24616376	0	glutamic_acid	28,41	glutamate_decarboxylase	71,94	glutamic acid	glutamate decarboxylase	CHEBI:18237	2752	Chemical	Gene	conversion|nmod|START_ENTITY END_ENTITY|nsubj|conversion	The selective conversion of glutamic_acid in amino_acid mixtures using glutamate_decarboxylase -- a means of separating amino_acids for synthesizing biobased chemicals .
3888659	0	glutamic_acid	34,47	glutamate_decarboxylase	51,74	glutamic acid	glutamate decarboxylase	CHEBI:18237	2752	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of phosphonic analogues of glutamic_acid on glutamate_decarboxylase .
12457039	0	glutamic_acid	48,61	progesterone_receptor	12,33	glutamic acid	progesterone receptor	CHEBI:18237	25154(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of the progesterone_receptor in restrained glutamic_acid decarboxylase gene expression in the hypothalamus during the preovulatory luteinizing hormone surge .
7238586	0	glutamic_acid	76,89	prolactin	17,26	glutamic acid	prolactin	CHEBI:18237	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	Possible role of prolactin in the modification of medial basal hypothalamic glutamic_acid decarboxylase activity .
15449951	0	glutamic_acid	53,66	rhodopsin	43,52	glutamic acid	rhodopsin	CHEBI:18237	509933(Tax:9913)	Chemical	Gene	START_ENTITY|nsubj|changes changes|nmod|END_ENTITY	Time-resolved photointermediate changes in rhodopsin glutamic_acid 181 mutants .
19678690	0	glutamic_acid	54,67	statherin	80,89	glutamic acid	statherin	CHEBI:18237	6779	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	A -LRB- 13 -RRB- C -LCB- -LRB- 31 -RRB- P -RCB- REDOR NMR investigation of the role of glutamic_acid residues in statherin - hydroxyapatite recognition .
2864098	0	glutamic_acid	33,46	tyrosine_hydroxylase	11,31	glutamic acid	tyrosine hydroxylase	CHEBI:18237	101823328	Chemical	Gene	START_ENTITY|nsubj|Changes Changes|nmod|END_ENTITY	Changes in tyrosine_hydroxylase , glutamic_acid decarboxylase and choline acetyltransferase after local microinoculation of scrapie agent into the nigrostriatal system of the golden_hamster .
17965879	0	glutamic_acid	58,71	vesicular_glutamate_transporters	16,48	glutamic acid	vesicular glutamate transporters	CHEBI:18237	84487(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Coexpression Coexpression|nmod|END_ENTITY	Coexpression of vesicular_glutamate_transporters 1 and 2 , glutamic_acid decarboxylase and calretinin in rat entorhinal cortex .
9188718	0	glutamic_acid185-alanine221	40,67	mannose-binding_protein_A	4,29	glutamic acid185-alanine221	mannose-binding protein A	null	24548(Tax:10116)	Chemical	Gene	region|nmod|START_ENTITY region|amod|END_ENTITY	The mannose-binding_protein_A region of glutamic_acid185-alanine221 can functionally replace the surfactant_protein_A region of glutamic_acid195-phenylalanine228 without loss of interaction with lipids and alveolar type II cells .
11605022	0	glutamic_acid_dimethyl_ester	16,44	GLP-1	48,53	glutamic acid dimethyl ester	GLP-1	null	24952(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|action action|compound|END_ENTITY	Potentiation by glutamic_acid_dimethyl_ester of GLP-1 insulinotropic action in fed anaesthetized rats .
15987430	0	glutamine	9,18	AIB1	4,8	glutamine	AIB1	CHEBI:28300	116833	Chemical	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	The AIB1 glutamine repeat polymorphism is not associated with risk of breast_cancer before age 40 years in Australian women .
24578449	0	glutamine	24,33	C-reactive_protein	52,70	glutamine	C-reactive protein	CHEBI:28300	1401	Chemical	Gene	administration|compound|START_ENTITY administration|nmod|END_ENTITY	Effect of perioperative glutamine administration on C-reactive_protein and liver function tests in patients undergoing hepatic resection .
6697421	0	glutamine	62,71	CCl4	85,89	glutamine	CCl4	CHEBI:28300	116637(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY synthesis|nmod|END_ENTITY	Hepatocyte heterogeneity in ammonia metabolism : impairment of glutamine synthesis in CCl4 induced liver_cell_necrosis with no effect on urea synthesis .
16843990	0	glutamine	45,54	Epidermal_growth_factor	0,23	glutamine	Epidermal growth factor	CHEBI:28300	25313(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY regulates|dobj|uptake regulates|nsubj|END_ENTITY	Epidermal_growth_factor regulates intestinal glutamine uptake during total parenteral nutrition .
14764791	0	glutamine	19,28	GFPT2	70,75	glutamine	GFPT2	CHEBI:28300	9945	Chemical	Gene	START_ENTITY|dep|gene gene|appos|END_ENTITY	Common variants in glutamine : fructose-6-phosphate_amidotransferase_2 -LRB- GFPT2 -RRB- gene are associated with type 2 diabetes , diabetic_nephropathy , and increased GFPT2 mRNA levels .
9615467	0	glutamine	10,19	GS1-2	31,36	glutamine	GS1-2	CHEBI:28300	542400(Tax:4577)	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	The maize glutamine synthetase GS1-2 gene is preferentially expressed in kernel pedicels and is developmentally-regulated .
10913032	0	glutamine	32,41	Growth_hormone	0,14	glutamine	Growth hormone	CHEBI:28300	2688	Chemical	Gene	production|compound|START_ENTITY decreases|dobj|production decreases|nsubj|END_ENTITY	Growth_hormone decreases muscle glutamine production and stimulates protein synthesis in hypercatabolic patients .
21853458	0	glutamine	50,59	HSP70	83,88	glutamine	HSP70	CHEBI:28300	266759(Tax:10116)	Chemical	Gene	therapy|amod|START_ENTITY therapy|compound|END_ENTITY	Combined microwave irradiation and intraarticular glutamine administration-induced HSP70 expression therapy prevents cartilage degradation in a rat osteoarthritis model .
25556350	0	glutamine	22,31	HSP70	51,56	glutamine	HSP70	D018698	3308	Chemical	Gene	supplementation|compound|START_ENTITY supplementation|nmod|END_ENTITY	The effect of 2 mMol glutamine supplementation on HSP70 and TNF-a release by LPS stimulated blood from healthy children .
11198353	0	glutamine	57,66	ICAM-1	20,26	glutamine	ICAM-1	CHEBI:28300	15894(Tax:10090)	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|expression expression|compound|END_ENTITY	Modulation of organ ICAM-1 expression during IV-TPN with glutamine and bombesin .
16674015	0	glutamine	32,41	ICAM-1	45,51	glutamine	ICAM-1	CHEBI:28300	3383	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of physiologic levels of glutamine on ICAM-1 expression in endothelial cells activated by preeclamptic plasma .
21834755	0	glutamine	63,72	L-Asparaginase	0,14	glutamine	L-Asparaginase	CHEBI:28300	80150	Chemical	Gene	addiction|amod|START_ENTITY disclose|dobj|addiction synthetase|xcomp|disclose synthetase|nsubj|END_ENTITY	L-Asparaginase and inhibitors of glutamine synthetase disclose glutamine addiction of b-catenin-mutated human hepatocellular_carcinoma cells .
23585457	0	glutamine	75,84	L-asparaginase	45,59	glutamine	L-asparaginase	CHEBI:28300	80150	Chemical	Gene	release|nmod|START_ENTITY END_ENTITY|nmod|release	Adipocytes cause leukemia cell resistance to L-asparaginase via release of glutamine .
26331698	0	glutamine	55,64	L-asparaginase	32,46	glutamine	L-asparaginase	D018698	80150	Chemical	Gene	START_ENTITY|nsubj|dose dose|nmod|targets targets|amod|END_ENTITY	A clinically attainable dose of L-asparaginase targets glutamine addiction in lymphoid cell lines .
3535170	0	glutamine	78,87	L-asparaginase	0,14	glutamine	L-asparaginase	CHEBI:28300	246307(Tax:10116)	Chemical	Gene	content|amod|START_ENTITY effects|nmod|content effects|amod|END_ENTITY	L-asparaginase effects on inhibition of protein synthesis and lowering of the glutamine content in cultured rat hepatocytes .
10903140	0	glutamine	96,105	LAT2	49,53	glutamine	LAT2	CHEBI:28300	7462	Chemical	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	The heterodimeric amino_acid transporter 4F2hc/y + LAT2 mediates arginine efflux in exchange with glutamine .
26095579	0	glutamine	8,17	Nrf_2	43,48	glutamine	Nrf 2	D018698	4780	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Enteral glutamine differentially regulates Nrf_2 along the villus-crypt axis of the intestine to enhance glutathione levels .
22550082	0	glutamine	70,79	PA200	25,30	glutamine	PA200	CHEBI:28300	23198	Chemical	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	The proteasome activator PA200 regulates tumor cell responsiveness to glutamine and resistance to ionizing radiation .
16257923	0	glutamine	48,57	PPAR-gamma	26,36	glutamine	PPAR-gamma	CHEBI:28300	25664(Tax:10116)	Chemical	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	Differential induction of PPAR-gamma by luminal glutamine and iNOS by luminal arginine in the rodent postischemic small bowel .
10071930	0	glutamine	51,60	RAP	84,87	glutamine	RAP	CHEBI:28300	4043	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Localization of a single transglutaminase-reactive glutamine in the third domain of RAP , the alpha2-macroglobulin receptor-associated protein .
23562301	0	glutamine	125,134	SIRT4	0,5	glutamine	SIRT4	D018698	75387(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY inhibiting|dobj|metabolism has|advcl|inhibiting has|nsubj|END_ENTITY	SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism .
23663782	0	glutamine	30,39	SIRT4	88,93	glutamine	SIRT4	CHEBI:28300	23409	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|nmod|END_ENTITY	The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4 .
23213057	0	glutamine	16,25	SLC1A5	0,6	glutamine	SLC1A5	CHEBI:28300	6510	Chemical	Gene	transport|amod|START_ENTITY mediates|dobj|transport mediates|nsubj|END_ENTITY	SLC1A5 mediates glutamine transport required for lung_cancer cell growth and survival .
12059969	0	glutamine	100,109	SN1	54,57	glutamine	SN1	CHEBI:28300	252919(Tax:10116)	Chemical	Gene	cycle|amod|START_ENTITY suggests|nmod|cycle suggests|nsubj|expression expression|nmod|END_ENTITY	Cell-specific expression of the glutamine transporter SN1 suggests differences in dependence on the glutamine cycle .
12528181	0	glutamine	55,64	SN1	34,37	glutamine	SN1	CHEBI:28300	252919(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|appos|transporter	Highly differential expression of SN1 , a bidirectional glutamine transporter , in astroglia and endothelium in the developing rat brain .
19233140	0	glutamine	98,107	SN1	28,31	glutamine	SN1	CHEBI:28300	10991	Chemical	Gene	transport|amod|START_ENTITY action|nmod|transport suggests|dobj|action suggests|nsubj|expression expression|nmod|END_ENTITY	Complementary expression of SN1 and SAT2 in the islets of Langerhans suggests concerted action of glutamine transport in the regulation of insulin secretion .
21525297	0	glutamine	86,95	SN1	108,111	glutamine	SN1	CHEBI:28300	252919(Tax:10116)	Chemical	Gene	START_ENTITY|ccomp|governs governs|nsubj|END_ENTITY	Protein kinase C-mediated phosphorylation of a single serine residue on the rat glial glutamine transporter SN1 governs its membrane trafficking .
15054072	0	glutamine	20,29	SNAT1	42,47	glutamine	SNAT1	CHEBI:28300	81539	Chemical	Gene	transporter|amod|START_ENTITY Localization|nmod|transporter END_ENTITY|nsubj|Localization	Localization of the glutamine transporter SNAT1 in rat cerebral cortex and neighboring structures , with a note on its localization in human cortex .
16954343	0	glutamine	70,79	SNAT3	64,69	glutamine	SNAT3	CHEBI:28300	252919(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Glucocorticoids have a role in renal cortical expression of the SNAT3 glutamine transporter during chronic metabolic_acidosis .
23418736	0	glutamine	20,29	SNAT3	42,47	glutamine	SNAT3	CHEBI:28300	10991	Chemical	Gene	release|compound|START_ENTITY release|nmod|END_ENTITY	GLAST/EAAT1-induced glutamine release via SNAT3 in Bergmann glial cells : evidence of a functional and physical coupling .
24854847	0	glutamine	14,23	SNAT3	45,50	glutamine	SNAT3	CHEBI:28300	10991	Chemical	Gene	Slc38a3|amod|START_ENTITY Slc38a3|appos|END_ENTITY	Expression of glutamine transporter Slc38a3 -LRB- SNAT3 -RRB- during acidosis is mediated by a different mechanism than tissue-specific expression .
25116356	0	glutamine	21,30	SNAT3	52,57	glutamine	SNAT3	CHEBI:28300	76257(Tax:10090)	Chemical	Gene	Slc38a3|amod|START_ENTITY Slc38a3|appos|END_ENTITY	Dysregulation of the glutamine transporter Slc38a3 -LRB- SNAT3 -RRB- and ammoniagenic enzymes in obese , glucose-intolerant mice .
23597559	0	glutamine	11,20	Sirt4	0,5	glutamine	Sirt4	CHEBI:28300	23409	Chemical	Gene	gatekeeper|amod|START_ENTITY END_ENTITY|dep|gatekeeper	Sirt4 : the glutamine gatekeeper .
19458124	0	glutamine	94,103	Slc38a3	123,130	glutamine	Slc38a3	CHEBI:28300	76257(Tax:10090)	Chemical	Gene	SNAT3|amod|START_ENTITY SNAT3|appos|END_ENTITY	Potassium restriction , high protein intake , and metabolic_acidosis increase expression of the glutamine transporter SNAT3 -LRB- Slc38a3 -RRB- in mouse kidney .
26490457	0	glutamine	41,50	Slc38a3	33,40	glutamine	Slc38a3	D018698	76257(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	Loss of function mutation of the Slc38a3 glutamine transporter reveals its critical role for amino_acid metabolism in the liver , brain , and kidney .
2868842	0	glutamine	77,86	adenylyltransferase	12,31	glutamine	adenylyltransferase	CHEBI:28300	20468722	Chemical	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	The role of adenylyltransferase and uridylyltransferase in the regulation of glutamine synthetase in Escherichia_coli .
15297807	0	glutamine	81,90	alpha-galactosidase_A	102,123	glutamine	alpha-galactosidase A	CHEBI:28300	2717	Chemical	Gene	START_ENTITY|nmod|protein protein|amod|END_ENTITY	Comparative in vitro expression study of four Fabry_disease causing mutations at glutamine 279 of the alpha-galactosidase_A protein .
19508204	0	glutamine	118,127	aminopeptidase	70,84	glutamine	aminopeptidase	CHEBI:28300	10404	Chemical	Gene	specificity|nmod|START_ENTITY END_ENTITY|nmod|specificity	Arginyl aminopeptidase-like 1 -LRB- RNPEPL1 -RRB- is an alternatively processed aminopeptidase with specificity for methionine , glutamine , and citrulline residues .
9339363	0	glutamine	54,63	apoB-100	82,90	glutamine	apoB-100	CHEBI:28300	338	Chemical	Gene	mutation|compound|START_ENTITY mutation|nmod|END_ENTITY	Estimation of the age of the ancestral arginine3500 -- > glutamine mutation in human apoB-100 .
9275150	0	glutamine	4,13	beta2-adrenoceptor	17,35	glutamine	beta2-adrenoceptor	CHEBI:28300	154	Chemical	Gene	polymorphism|amod|START_ENTITY polymorphism|amod|END_ENTITY	The glutamine 27 beta2-adrenoceptor polymorphism is associated with elevated IgE levels in asthmatic families .
24642654	0	glutamine	10,19	caspase-3	23,32	glutamine	caspase-3	CHEBI:28300	25402(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|mRNA mRNA|amod|END_ENTITY	Effect of glutamine on caspase-3 mRNA and protein expression in the myocardium of rats with sepsis .
25599677	0	glutamine	13,22	cytosolic_phospholipase_a2	37,63	glutamine	cytosolic phospholipase a2	D018698	18783(Tax:10090)	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Mechanism of glutamine inhibition of cytosolic_phospholipase_a2 -LRB- cPLA2 -RRB- : Evidence of physical interaction between glutamine-Induced mitogen-activated protein kinase phosphatase-1 and cPLA2 .
19374817	0	glutamine	12,21	extracellular_signal_regulated_kinase	25,62	glutamine	extracellular signal regulated kinase	CHEBI:28300	24338(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|amod|END_ENTITY	-LSB- Effects of glutamine on extracellular_signal_regulated_kinase and p38MAPK expression in the kidney in young rats with endotoxemia -RSB- .
20802180	0	glutamine	154,163	glial_fibrillary_acidic_protein	121,152	glutamine	glial fibrillary acidic protein	CHEBI:28300	2670	Chemical	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Adaptive calcified matrix response of dental pulp to bacterial invasion is associated with establishment of a network of glial_fibrillary_acidic_protein + / glutamine synthetase + cells .
19056578	0	glutamine	5,14	glucagon-like_peptide_1	37,60	glutamine	glucagon-like peptide 1	CHEBI:28300	2641	Chemical	Gene	increases|nsubj|START_ENTITY increases|xcomp|circulating circulating|dobj|END_ENTITY	Oral glutamine increases circulating glucagon-like_peptide_1 , glucagon , and insulin concentrations in lean , obese , and type 2 diabetic subjects .
18468467	0	glutamine	123,132	glutamine_synthetase	16,36	glutamine	glutamine synthetase	CHEBI:28300	100054716(Tax:9796)	Chemical	Gene	START_ENTITY|nsubj|Distribution Distribution|nmod|END_ENTITY	Distribution of glutamine_synthetase and an inverse relationship between glutamine_synthetase expression and intramuscular glutamine concentration in the horse .
19002891	0	glutamine	128,137	glutamine_synthetase	80,100	glutamine	glutamine synthetase	CHEBI:28300	100764163	Chemical	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	Metabolic characteristics of recombinant Chinese_hamster ovary cells expressing glutamine_synthetase in presence and absence of glutamine .
16363123	0	glutamine	11,20	grp75	42,47	glutamine	grp75	CHEBI:28300	291671(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of glutamine on the expression of grp75 in PC12 cells -RSB- .
15973519	0	glutamine	11,20	heat_shock_protein_70	37,58	glutamine	heat shock protein 70	CHEBI:28300	3308	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Parenteral glutamine increases serum heat_shock_protein_70 in critically_ill patients .
23906405	0	glutamine	12,21	heat_shock_protein_70	30,51	glutamine	heat shock protein 70	CHEBI:28300	266759(Tax:10116)	Chemical	Gene	START_ENTITY|acl|induced induced|dobj|overexpression overexpression|amod|END_ENTITY	-LSB- Effects of glutamine induced heat_shock_protein_70 overexpression on atrial_fibrosis and connexin_43 remodeling in isoprenaline-treated rats -RSB- .
25701159	0	glutamine	91,100	heat_shock_protein_70	21,42	glutamine	heat shock protein 70	CHEBI:28300	3308	Chemical	Gene	supplementation|amod|START_ENTITY trial|nmod|supplementation effects|dep|trial effects|nmod|END_ENTITY	Glutamine effects on heat_shock_protein_70 and interleukines 6 and 10 : Randomized trial of glutamine supplementation versus standard parenteral nutrition in critically ill children .
26706024	0	glutamine	51,60	heat_shock_protein_70	107,128	glutamine	heat shock protein 70	D018698	3308	Chemical	Gene	mM|dobj|START_ENTITY mM|nmod|release release|nmod|mediators mediators|amod|END_ENTITY	An in vitro model to consider the effect of 2 mM glutamine and KNK437 on endotoxin-stimulated release of heat_shock_protein_70 and inflammatory mediators .
12221210	0	glutamine	14,23	heme_oxygenase-1	42,58	glutamine	heme oxygenase-1	CHEBI:28300	3162	Chemical	Gene	infusion|compound|START_ENTITY enhances|nsubj|infusion enhances|dobj|expression expression|amod|END_ENTITY	Acute enteral glutamine infusion enhances heme_oxygenase-1 expression in human duodenal mucosa .
16531144	0	glutamine	44,53	heme_oxygenase-1	108,124	glutamine	heme oxygenase-1	CHEBI:28300	3162	Chemical	Gene	induction|nmod|START_ENTITY effect|nmod|induction effect|dep|effect effect|nmod|END_ENTITY	The effect of heme_oxygenase-1 induction by glutamine on radiation-induced intestinal_damage : the effect of heme_oxygenase-1 on radiation_enteritis .
16531144	0	glutamine	44,53	heme_oxygenase-1	14,30	glutamine	heme oxygenase-1	CHEBI:28300	3162	Chemical	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	The effect of heme_oxygenase-1 induction by glutamine on radiation-induced intestinal_damage : the effect of heme_oxygenase-1 on radiation_enteritis .
17124609	0	glutamine	44,53	heme_oxygenase-1	14,30	glutamine	heme oxygenase-1	CHEBI:28300	24451(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|induction induction|amod|END_ENTITY	The effect of heme_oxygenase-1 induction by glutamine on TNBS-induced colitis .
18497709	0	glutamine	68,77	heme_oxygenase-1	82,98	glutamine	heme oxygenase-1	CHEBI:28300	24451(Tax:10116)	Chemical	Gene	injury|nmod|START_ENTITY Prevention|nmod|injury Prevention|nmod|induction induction|amod|END_ENTITY	Prevention of hemorrhagic_shock-induced intestinal tissue injury by glutamine via heme_oxygenase-1 induction .
19468257	0	glutamine	18,27	heme_oxygenase-1	133,149	glutamine	heme oxygenase-1	CHEBI:28300	3162	Chemical	Gene	Pretreatment|nmod|START_ENTITY attenuates|nsubj|Pretreatment attenuates|dobj|injury injury|nmod|cells cells|nmod|induction induction|nmod|END_ENTITY	Pretreatment with glutamine attenuates anoxia/reoxygenation injury of human proximal renal tubular epithelial cells via induction of heme_oxygenase-1 .
23172166	0	glutamine	28,37	heme_oxygenase-1	94,110	glutamine	heme oxygenase-1	CHEBI:28300	24451(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|induction induction|nmod|END_ENTITY	Tissue-protective effect of glutamine on hepatic_ischemia-reperfusion_injury via induction of heme_oxygenase-1 .
2956263	1	glutamine	90,99	heparan_sulfate_proteoglycan	120,148	glutamine	heparan sulfate proteoglycan	CHEBI:28300	960	Chemical	Gene	START_ENTITY|nmod|synthesis synthesis|nmod|END_ENTITY	Effects of 6-diazo-5-oxo-L-norleucine and low glutamine on the synthesis of heparan_sulfate_proteoglycan by human colon_carcinoma cells .
17083784	0	glutamine	12,21	matrix_metalloproteinase-3	25,51	glutamine	matrix metalloproteinase-3	CHEBI:28300	171045(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expressions expressions|amod|END_ENTITY	-LSB- Effects of glutamine on matrix_metalloproteinase-3 and tissue_inhibitor_of_metalloproteinase-3 expressions in myocardium of rats with sepsis -RSB- .
11804205	0	glutamine	7,16	ornithine_carbamoyltransferase	47,77	glutamine	ornithine carbamoyltransferase	CHEBI:28300	5009	Chemical	Gene	START_ENTITY|nmod|deficiency deficiency|amod|END_ENTITY	Plasma glutamine and ammonia concentrations in ornithine_carbamoyltransferase deficiency and citrullinaemia .
16898871	0	glutamine	67,76	p53	14,17	glutamine	p53	CHEBI:28300	301300(Tax:10116)	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|END_ENTITY	Modulation of p53 and c-myc in DMBA-induced mammary_tumors by oral glutamine .
187382	0	glutamine	51,60	phosphoenolpyruvate_carboxykinase	14,47	glutamine	phosphoenolpyruvate carboxykinase	CHEBI:28300	362282(Tax:10116)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of phosphoenolpyruvate_carboxykinase by glutamine and ATP as possible control mechanisms of renal gluconeogenesis .
7388677	0	glutamine	78,87	phosphoenolpyruvate_carboxykinase	10,43	glutamine	phosphoenolpyruvate carboxykinase	CHEBI:28300	403560(Tax:9615)	Chemical	Gene	metabolism|nmod|START_ENTITY inhibition|nmod|metabolism inhibition|amod|END_ENTITY	Effect of phosphoenolpyruvate_carboxykinase inhibition on renal metabolism of glutamine : in vivo studies in the dog and rat .
6673453	0	glutamine	10,19	prolactin	39,48	glutamine	prolactin	CHEBI:28300	24683(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of glutamine and nucleosides on prolactin secretion in the rat .
20170637	0	glutamine	35,44	transglutaminase	95,111	glutamine	transglutaminase	CHEBI:28300	100379228(Tax:10141)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Post-translational modification of glutamine and lysine residues of HIV-1 aspartyl protease by transglutaminase increases its catalytic activity .
17284860	0	glutamine	23,32	tumor_necrosis_factor	44,65	glutamine	tumor necrosis factor	CHEBI:28300	103694380	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Restoration by dietary glutamine of reduced tumor_necrosis_factor production in a low-protein-diet-fed rat model .
10555775	0	glutamine	57,66	vimentin	45,53	glutamine	vimentin	CHEBI:28300	22352(Tax:10090)	Chemical	Gene	levels|compound|START_ENTITY END_ENTITY|nmod|levels	The impact of genetic removal of GFAP and/or vimentin on glutamine levels and transport of glucose and ascorbate in astrocytes .
15231017	0	glutaminyl	63,73	QPCT	88,92	glutaminyl	QPCT	CHEBI:24320	25797	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of multiple nucleotide variations in the pituitary glutaminyl cyclase gene -LRB- QPCT -RRB- with low radial BMD in adult women .
9070837	0	glutamyl	20,28	aminopeptidase	29,43	glutamyl	aminopeptidase	CHEBI:32483	10404	Chemical	Gene	Reduction|nmod|START_ENTITY END_ENTITY|nsubj|Reduction	Reduction of plasma glutamyl aminopeptidase activity in sporadic Alzheimer 's _ disease .
6295178	0	glutaraldehyde	10,24	vasopressin	68,79	glutaraldehyde	vasopressin	MESH:D005976	551	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of glutaraldehyde on hydrosmotic response of toad bladder to vasopressin .
10327586	0	glutardialdehyde	40,56	beta_2glycoprotein_I	16,36	glutardialdehyde	beta 2glycoprotein I	MESH:D005976	350	Chemical	Gene	Modification|nmod|START_ENTITY Modification|nmod|END_ENTITY	Modification of beta_2glycoprotein_I by glutardialdehyde .
7510792	0	glutathione	82,93	3_alpha-hydroxysteroid_dehydrogenase	14,50	glutathione	3 alpha-hydroxysteroid dehydrogenase	MESH:D005978	291283(Tax:10116)	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|activity activity|amod|END_ENTITY	Modulation of 3_alpha-hydroxysteroid_dehydrogenase activity by the redox state of glutathione .
19283589	0	glutathione	29,40	ADA	65,68	glutathione	ADA	MESH:D005978	11486(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nsubj|effects	Antiepileptogenic effects of glutathione against increased brain ADA in PTZ-induced epilepsy .
18654882	0	glutathione	116,127	ATF4	172,176	glutathione	ATF4	MESH:D005978	79255(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Gamma-tocopheryl_quinone , not alpha-tocopheryl_quinone , induces adaptive response through up-regulation of cellular glutathione and cysteine availability via activation of ATF4 .
9703946	0	glutathione	44,55	Bcl-2	14,19	glutathione	Bcl-2	MESH:D005978	596	Chemical	Gene	increases|dobj|START_ENTITY increases|nsubj|Expression Expression|nmod|END_ENTITY	Expression of Bcl-2 increases intracellular glutathione by inhibiting methionine-dependent GSH efflux .
20654322	0	glutathione	43,54	CD3	92,95	glutathione	CD3	MESH:D005978	12501(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	The effect of in vitro phorone exposure on glutathione content and T cell antigen receptor -LRB- CD3 -RRB- - stimulated calcium mobilization in murine splenic T lymphocytes .
11390189	0	glutathione	76,87	CFTR	114,118	glutathione	CFTR	MESH:D005978	1080	Chemical	Gene	transport|compound|START_ENTITY role|nmod|transport role|acl|caused caused|nmod|mutation mutation|amod|END_ENTITY	Rethinking cystic_fibrosis pathology : the critical role of abnormal reduced glutathione -LRB- GSH -RRB- transport caused by CFTR mutation .
12727866	0	glutathione	44,55	CFTR	0,4	glutathione	CFTR	MESH:D005978	1080	Chemical	Gene	flux|compound|START_ENTITY mediates|dobj|flux mediates|nsubj|END_ENTITY	CFTR directly mediates nucleotide-regulated glutathione flux .
17369290	0	glutathione	36,47	CFTR	11,15	glutathione	CFTR	MESH:D005978	12638(Tax:10090)	Chemical	Gene	levels|amod|START_ENTITY elevation|nmod|levels role|nmod|elevation role|nmod|END_ENTITY	A role for CFTR in the elevation of glutathione levels in the lung by oral glutathione administration .
17369290	0	glutathione	75,86	CFTR	11,15	glutathione	CFTR	MESH:D005978	12638(Tax:10090)	Chemical	Gene	administration|compound|START_ENTITY lung|nmod|administration role|nmod|lung role|nmod|END_ENTITY	A role for CFTR in the elevation of glutathione levels in the lung by oral glutathione administration .
19906953	0	glutathione	70,81	CFTR	0,4	glutathione	CFTR	MESH:D005978	12638(Tax:10090)	Chemical	Gene	efflux|amod|START_ENTITY controlling|dobj|efflux mediates|advcl|controlling mediates|nsubj|END_ENTITY	CFTR mediates apoptotic volume decrease and cell death by controlling glutathione efflux and ROS production in cultured mice proximal tubules .
22266045	0	glutathione	33,44	CFTR	0,4	glutathione	CFTR	MESH:D005978	12638(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|nsubj|END_ENTITY	CFTR is the primary known apical glutathione transporter involved in cigarette smoke-induced adaptive responses in the lung .
6502092	0	glutathione	10,21	Catalase	0,8	glutathione	Catalase	MESH:D005978	847	Chemical	Gene	dismutase|nsubj|START_ENTITY dismutase|advmod|END_ENTITY	Catalase , glutathione peroxidase , and superoxide dismutase in the rete mirabile and gas gland epithelium of six species of marine fishes .
12230881	0	glutathione	30,41	Cathepsin_B	0,11	glutathione	Cathepsin B	MESH:D005978	64529(Tax:10116)	Chemical	Gene	responsiveness|xcomp|START_ENTITY responsiveness|nsubj|END_ENTITY	Cathepsin_B responsiveness to glutathione and lipoic_acid redox .
16227205	0	glutathione	18,29	DJ-1	0,4	glutathione	DJ-1	MESH:D005978	11315	Chemical	Gene	START_ENTITY|nsubj|up-regulates up-regulates|compound|END_ENTITY	DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein toxicity .
15334031	0	glutathione	25,36	Erythropoietin	0,14	glutathione	Erythropoietin	MESH:D005978	24335(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|increases increases|compound|END_ENTITY	Erythropoietin increases glutathione peroxidase enzyme activity and decreases lipid peroxidation levels in hypoxic-ischemic_brain_injury in neonatal rats .
10575337	0	glutathione	18,29	Fog	53,56	glutathione	Fog	MESH:D005978	161882	Chemical	Gene	START_ENTITY|nmod|response response|nmod|END_ENTITY	Effect of inhaled glutathione on airway response to ` Fog ' challenge in asthmatic patients .
19276532	0	glutathione	40,51	GCL	14,17	glutathione	GCL	MESH:D005978	2729	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of GCL activity and cellular glutathione through inhibition of ERK phosphorylation .
12064474	0	glutathione	19,30	GP120	10,15	glutathione	GP120	MESH:D005978	3700	Chemical	Gene	activity|amod|START_ENTITY Effect|nmod|activity Effect|nmod|END_ENTITY	Effect of GP120 on glutathione peroxidase activity in cortical cultures and the interaction with steroid hormones .
12829378	0	glutathione	28,39	GPX1	52,56	glutathione	GPX1	MESH:D005978	2876	Chemical	Gene	delays|amod|START_ENTITY delays|appos|END_ENTITY	Overexpression of cytosolic glutathione peroxidase -LRB- GPX1 -RRB- delays endothelial cell growth and increases resistance to toxic challenges .
15348345	5	glutathione	567,578	GSH	580,583	glutathione	GST	MESH:D005978	373156	Chemical	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Cr_VI caused depletion of intracellular reduced glutathione -LRB- GSH -RRB- levels , and inhibition of glutathione_reductase and glutathione-S-transferase -LRB- GST -RRB- activities .
24460377	8	glutathione	1291,1302	GSH	1304,1307	glutathione	p38	MESH:D005978	26416(Tax:10090)	Chemical	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	DBE also prevented glutamate-induced oxidative stress , as indicated by increased reactive oxygen species and lipid peroxidation as well as by decreases in glutathione -LRB- GSH -RRB- levels and GSH peroxidase activity .
12173466	0	glutathione	36,47	GSTT1	69,74	glutathione	GSTT1	MESH:D005978	2952	Chemical	Gene	START_ENTITY|dobj|genes genes|appos|END_ENTITY	-LSB- Polymorphism of the theta1 and mu1 glutathione s-transferase genes -LRB- GSTT1 , GSTM1 -RRB- in patients with atopic_bronchial_asthma from the West Siberian region -RSB- .
9851677	0	glutathione	27,38	GSTT1-1	51,58	glutathione	GSTT1-1	MESH:D005978	14871(Tax:10090)	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Species differences in the glutathione transferase GSTT1-1 activity towards the model substrates methyl_chloride and dichloromethane in liver and kidney .
17952457	0	glutathione	77,88	Glucose-6-phosphate_dehydrogenase	0,33	glutathione	Glucose-6-phosphate dehydrogenase	MESH:D005978	2539	Chemical	Gene	levels|compound|START_ENTITY modulating|dobj|levels plays|advcl|modulating plays|nsubj|END_ENTITY	Glucose-6-phosphate_dehydrogenase plays a central role in modulating reduced glutathione levels in reed callus under salt stress .
14596823	0	glutathione	72,83	Glutathione_S-transferase	0,25	glutathione	Glutathione S-transferase	MESH:D005978	373156	Chemical	Gene	resin|amod|START_ENTITY immobilized|dobj|resin immobilized|nsubj|assays assays|amod|END_ENTITY	Glutathione_S-transferase pull-down assays using dehydrated immobilized glutathione resin .
8706254	0	glutathione	132,143	Glutathione_S-transferase	0,25	glutathione	Glutathione S-transferase	MESH:D005978	373156	Chemical	Gene	diol_epoxides|nmod|START_ENTITY diol_epoxides|nsubj|conjugation conjugation|amod|END_ENTITY	Glutathione_S-transferase A1-1-catalysed conjugation of bay and fjord region diol_epoxides or polycyclic_aromatic_hydrocarbons with glutathione .
3705515	0	glutathione	93,104	Glutathione_reductase	1,22	glutathione	Glutathione reductase	MESH:D005978	116686(Tax:10116)	Chemical	Gene	level|amod|START_ENTITY -RSB-|advcl|level -RSB-|nsubj|END_ENTITY	-LSB- Glutathione_reductase and glutathione_S-aryltransferase in the rat liver depending upon the glutathione level -RSB- .
11418106	0	glutathione	16,27	Gpx-1	54,59	glutathione	Gpx-1	MESH:D005978	2876	Chemical	Gene	proteins|amod|START_ENTITY proteins|dep|END_ENTITY	NADPH-dependent glutathione peroxidase-like proteins -LRB- Gpx-1 , Gpx-2 -RRB- reduce unsaturated_fatty_acid hydroperoxides in Synechocystis_PCC_6803 .
15247035	0	glutathione	40,51	Growth_hormone	0,14	glutathione	Growth hormone	MESH:D005978	14599(Tax:10090)	Chemical	Gene	pathway|amod|START_ENTITY components|nmod|pathway alters|dobj|components alters|nsubj|END_ENTITY	Growth_hormone alters components of the glutathione metabolic pathway in Ames dwarf mice .
9620880	0	glutathione	57,68	Growth_hormone	0,14	glutathione	Growth hormone	MESH:D005978	81668(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Growth_hormone - and testosterone-dependent regulation of glutathione transferase subunit A5 in rat liver .
22426019	11	glutathione	1571,1582	H2O2	1594,1598	glutathione	Nrf2	MESH:D005978	4780	Chemical	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Moreover , Nps-Cur was able to protect SK-N-SH cells against H2O2 and prevent the elevation of reactive oxygen species and the consumption of glutathione induced by H2O2 .
24392144	0	glutathione	71,82	HMGN5	62,67	glutathione	HMGN5	MESH:D005978	50887(Tax:10090)	Chemical	Gene	metabolism|amod|START_ENTITY END_ENTITY|nmod|metabolism	Metabolomics reveals a role for the chromatin-binding protein HMGN5 in glutathione metabolism .
16249513	0	glutathione	70,81	Hepatocyte_growth_factor	0,24	glutathione	Hepatocyte growth factor	MESH:D005978	3082	Chemical	Gene	depletion|amod|START_ENTITY induced|nmod|depletion apoptosis|acl|induced protects|nmod|apoptosis protects|nsubj|END_ENTITY	Hepatocyte_growth_factor protects RPE cells from apoptosis induced by glutathione depletion .
15821937	0	glutathione	119,130	Hgt1p	144,149	glutathione	Hgt1p	MESH:D005978	853218(Tax:4932)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Multiple cis-regulatory elements and the yeast sulphur regulatory network are required for the regulation of the yeast glutathione transporter , Hgt1p .
19496824	0	glutathione	71,82	Hgt1p	96,101	glutathione	Hgt1p	MESH:D005978	853218(Tax:4932)	Chemical	Gene	transporter|compound|START_ENTITY residues|nmod|transporter played|nmod|residues played|advmod|END_ENTITY	Differential roles played by the native cysteine residues of the yeast glutathione transporter , Hgt1p .
19589778	0	glutathione	138,149	Hgt1p	163,168	glutathione	Hgt1p	MESH:D005978	853218(Tax:4932)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Gln-222 in transmembrane domain 4 and Gln-526 in transmembrane domain 9 are critical for substrate recognition in the yeast high affinity glutathione transporter , Hgt1p .
23261989	0	glutathione	39,50	Insulin-like_growth_factor-1	0,28	glutathione	Insulin-like growth factor-1	MESH:D005978	3479	Chemical	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Insulin-like_growth_factor-1 regulates glutathione peroxidase expression and activity in vascular endothelial cells : Implications for atheroprotective actions of insulin-like_growth_factor-1 .
10708754	0	glutathione	14,25	MRP1	52,56	glutathione	MRP1	MESH:D005978	4363	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of glutathione on the ATPase activity of MRP1 in its natural membranes .
10773025	0	glutathione	21,32	MRP1	90,94	glutathione	MRP1	MESH:D005978	4363	Chemical	Gene	START_ENTITY|nmod|multidrug_resistance_protein_1 multidrug_resistance_protein_1|appos|END_ENTITY	Verapamil stimulates glutathione transport by the 190-kDa multidrug_resistance_protein_1 -LRB- MRP1 -RRB- .
11389878	0	glutathione	14,25	MRP1	126,130	glutathione	MRP1	MESH:D005978	8714	Chemical	Gene	Influences|nmod|START_ENTITY Influences|acl|expressing expressing|dobj|END_ENTITY	Influences of glutathione on anionic substrate efflux in tumour cells expressing the multidrug_resistance-associated_protein , MRP1 .
11448450	0	glutathione	21,32	MRP1	91,95	glutathione	MRP1	MESH:D005978	8714	Chemical	Gene	transport|compound|START_ENTITY transport|appos|END_ENTITY	Verapamil-stimulated glutathione transport by the multidrug_resistance-associated_protein -LRB- MRP1 -RRB- in leukaemia cells .
12485947	0	glutathione	28,39	MRP1	97,101	glutathione	MRP1	MESH:D005978	4363	Chemical	Gene	transport|amod|START_ENTITY stimulation|nmod|transport stimulation|nmod|multidrug_resistance_protein_1 multidrug_resistance_protein_1|appos|END_ENTITY	Bioflavonoid stimulation of glutathione transport by the 190-kDa multidrug_resistance_protein_1 -LRB- MRP1 -RRB- .
15256468	0	glutathione	55,66	MRP1	109,113	glutathione	MRP1	MESH:D005978	4363	Chemical	Gene	extrusion|amod|START_ENTITY apoptosis|nmod|extrusion apoptosis|advcl|multidrug multidrug|dobj|END_ENTITY	Verapamil and its derivative trigger apoptosis through glutathione extrusion by multidrug resistance protein MRP1 .
16784241	0	glutathione	81,92	MRP1	74,78	glutathione	MRP1	MESH:D005978	4363	Chemical	Gene	conjugation|amod|START_ENTITY inhibit|nsubj|conjugation signaling|parataxis|inhibit signaling|nmod|multidrug_resistance_protein_1 multidrug_resistance_protein_1|appos|END_ENTITY	Modulation of nitrated lipid signaling by multidrug_resistance_protein_1 -LRB- MRP1 -RRB- : glutathione conjugation and MRP1-mediated efflux inhibit nitrolinoleic_acid-induced , PPARgamma-dependent transcription activation .
16820223	0	glutathione	13,24	MRP1	55,59	glutathione	MRP1	MESH:D005978	4363	Chemical	Gene	Transport|nmod|START_ENTITY conjugates|nsubj|Transport conjugates|nmod|END_ENTITY	Transport of glutathione and glutathione conjugates by MRP1 .
21925487	0	glutathione	9,20	MRP1	181,185	glutathione	MRP1	MESH:D005978	4363	Chemical	Gene	START_ENTITY|nmod|4-hydroxy-2-nonenal 4-hydroxy-2-nonenal|nmod|cells cells|acl|expressing expressing|dobj|protein-1 protein-1|appos|END_ENTITY	Enhanced glutathione depletion , protein adduct formation , and cytotoxicity following exposure to 4-hydroxy-2-nonenal -LRB- HNE -RRB- in cells expressing human multidrug resistance protein-1 -LRB- MRP1 -RRB- together with human glutathione_S-transferase-M1 -LRB- GSTM1 -RRB- .
9377473	0	glutathione	13,24	MRP1	90,94	glutathione	MRP1	MESH:D005978	4363	Chemical	Gene	Transport|nmod|START_ENTITY conjugates|nsubj|Transport conjugates|nmod|END_ENTITY	Transport of glutathione conjugates and glucuronides by the multidrug resistance proteins MRP1 and MRP2 .
16539673	0	glutathione	76,87	Mrp1	36,40	glutathione	Mrp1	MESH:D005978	18669(Tax:10090)	Chemical	Gene	export|nmod|START_ENTITY mediates|dobj|export mediates|nsubj|multidrug_resistance_protein_1 multidrug_resistance_protein_1|appos|END_ENTITY	The multidrug_resistance_protein_1 -LRB- Mrp1 -RRB- , but not Mrp5 , mediates export of glutathione and glutathione_disulfide from brain astrocytes .
11055542	1	glutathione	107,118	NADPH	93,98	glutathione	NADPH	MESH:D005978	1666	Chemical	Gene	START_ENTITY|nsubj|Evidence Evidence|nmod|involvement involvement|nmod|END_ENTITY	Evidence for involvement of NADPH and not glutathione as the reductant .
7781927	0	glutathione	72,83	NF_kappa_B	35,45	glutathione	NF kappa B	MESH:D005978	4790	Chemical	Gene	levels|compound|START_ENTITY END_ENTITY|nmod|levels	Modulation of transcription factor NF_kappa_B activity by intracellular glutathione levels and by variations of the extracellular cysteine supply .
8831677	0	glutathione	131,142	NF_kappa_B	8,18	glutathione	NF kappa B	MESH:D005978	4790	Chemical	Gene	dependent|nmod|START_ENTITY mediated|ccomp|dependent mediated|nsubj|END_ENTITY	Optimal NF_kappa_B mediated transcriptional responses in Jurkat T cells exposed to oxidative stress are dependent on intracellular glutathione and costimulatory signals .
9003388	1	glutathione	220,231	NF_kappa_B	266,276	glutathione	NF kappa B	MESH:D005978	4790	Chemical	Gene	START_ENTITY|nmod|mechanism mechanism|nmod|inhibition inhibition|nmod|END_ENTITY	Evidence for oxidation of glutathione in the mechanism of inhibition of NF_kappa_B by PDTC .
11490092	0	glutathione	33,44	Nerve_growth_factor	0,19	glutathione	Nerve growth factor	MESH:D005978	310738(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|compound|END_ENTITY	Nerve_growth_factor and striatal glutathione metabolism in a rat model of Huntington 's _ disease .
11118612	0	glutathione	23,34	Nrf2	96,100	glutathione	Nrf2	MESH:D005978	18024(Tax:10090)	Chemical	Gene	genes|amod|START_ENTITY expression|nmod|genes expression|nmod|protein protein|amod|END_ENTITY	Impaired expression of glutathione synthetic enzyme genes in mice with targeted deletion of the Nrf2 basic-leucine zipper protein .
14681686	0	glutathione	84,95	Nrf2	0,4	glutathione	Nrf2	MESH:D005978	18024(Tax:10090)	Chemical	Gene	levels|compound|START_ENTITY affecting|dobj|levels regulates|advcl|affecting regulates|nsubj|END_ENTITY	Nrf2 regulates the sensitivity of death receptor signals by affecting intracellular glutathione levels .
14985508	0	glutathione	71,82	Nrf2	39,43	glutathione	Nrf2	MESH:D005978	83619(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY loss|nmod|synthesis causes|dobj|loss causes|nsubj|Decline Decline|nmod|activity activity|nmod|END_ENTITY	Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis , which is reversible with lipoic_acid .
15582588	0	glutathione	25,36	Nrf2	65,69	glutathione	Nrf2	MESH:D005978	4780	Chemical	Gene	metabolism|amod|START_ENTITY regulation|nmod|metabolism regulation|nmod|astrocytes astrocytes|nmod|END_ENTITY	Coordinate regulation of glutathione metabolism in astrocytes by Nrf2 .
16524372	0	glutathione	10,21	Nrf2	38,42	glutathione	Nrf2	MESH:D005978	83619(Tax:10116)	Chemical	Gene	biosynthesis|compound|START_ENTITY biosynthesis|nmod|activation activation|amod|END_ENTITY	Increased glutathione biosynthesis by Nrf2 activation in astrocytes prevents p75NTR-dependent motor neuron apoptosis .
16806086	0	glutathione	20,31	Nrf2	88,92	glutathione	Nrf2	MESH:D005978	18024(Tax:10090)	Chemical	Gene	biosynthesis|amod|START_ENTITY biosynthesis|nmod|activation activation|nmod|END_ENTITY	Bucillamine induces glutathione biosynthesis via activation of the transcription factor Nrf2 .
18162601	0	glutathione	20,31	Nrf2	59,63	glutathione	Nrf2	MESH:D005978	4780	Chemical	Gene	synthesis|amod|START_ENTITY induces|dobj|synthesis induces|nmod|activation activation|nmod|END_ENTITY	Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells .
18814142	0	glutathione	125,136	Nrf2	153,157	glutathione	Nrf2	MESH:D005978	18024(Tax:10090)	Chemical	Gene	synthesis|amod|START_ENTITY promotion|nmod|synthesis stress|nmod|promotion stress|nmod|upregulation upregulation|amod|END_ENTITY	Functional expression of beta2 adrenergic receptors responsible for protection against oxidative stress through promotion of glutathione synthesis after Nrf2 upregulation in undifferentiated mesenchymal C3H10T1/2 stem cells .
20513363	0	glutathione	36,47	Nrf2	80,84	glutathione	Nrf2	MESH:D005978	83619(Tax:10116)	Chemical	Gene	synthesis|compound|START_ENTITY synthesis|nmod|activation activation|nmod|END_ENTITY	1 , _ 5-Dicaffeoylquinic_acid-mediated glutathione synthesis through activation of Nrf2 protects against OGD/reperfusion-induced oxidative stress in astrocytes .
22142473	0	glutathione	49,60	Nrf2	80,84	glutathione	Nrf2	MESH:D005978	4780	Chemical	Gene	depletion|amod|START_ENTITY line|nmod|depletion Resistance|nmod|line involves|nsubj|Resistance involves|xcomp|END_ENTITY	Resistance of neuroblastoma GI-ME-N cell line to glutathione depletion involves Nrf2 and heme_oxygenase-1 .
22212472	0	glutathione	149,160	Nrf2	31,35	glutathione	Nrf2	MESH:D005978	83619(Tax:10116)	Chemical	Gene	capacity|amod|START_ENTITY loss|nmod|capacity means|nmod|loss Identification|dep|means Identification|nmod|locus locus|amod|END_ENTITY	Identification of age-specific Nrf2 binding to a novel antioxidant response element locus in the Gclc promoter : a compensatory means for the loss of glutathione synthetic capacity in the aging rat liver ?
22272109	0	glutathione	10,21	Nrf2	42,46	glutathione	Nrf2	MESH:D005978	4780	Chemical	Gene	synthesis|amod|START_ENTITY synthesis|nmod|END_ENTITY	Increased glutathione synthesis following Nrf2 activation by vanadyl_sulfate in human chang liver cells .
22390303	7	glutathione	1254,1265	Nrf2	1219,1223	glutathione	NOS2	MESH:D005978	18126(Tax:10090)	Chemical	Gene	depletion|compound|START_ENTITY protected|nmod|depletion END_ENTITY|acl|protected	In cytokine-stimulated cells , Nrf2 protected from GSNORi-induced glutathione depletion and cytotoxicity and HO-1 activity was required for down-regulation of NOS2 .
23618921	0	glutathione	93,104	Nrf2	51,55	glutathione	Nrf2	MESH:D005978	4780	Chemical	Gene	levels|amod|START_ENTITY enhancement|nmod|levels mediates|dobj|enhancement mediates|nsubj|regulation regulation|nmod|END_ENTITY	Concurrent regulation of the transcription factors Nrf2 and ATF4 mediates the enhancement of glutathione levels by the flavonoid_fisetin .
24191238	0	glutathione	40,51	Nrf2	10,14	glutathione	Nrf2	MESH:D005978	4780	Chemical	Gene	release|nmod|START_ENTITY activators|nmod|release activators|nsubj|Effect Effect|nmod|END_ENTITY	Effect of Nrf2 activators on release of glutathione , cysteinylglycine and homocysteine by human U373 astroglial cells .
25529839	0	glutathione	21,32	Nrf2	83,87	glutathione	Nrf2	MESH:D005978	83619(Tax:10116)	Chemical	Gene	increases|dobj|START_ENTITY increases|advcl|stimulating stimulating|dobj|pathway pathway|amod|END_ENTITY	Epalrestat increases glutathione , thioredoxin , and heme_oxygenase-1 by stimulating Nrf2 pathway in endothelial cells .
23255614	0	glutathione	60,71	OAT1	32,36	glutathione	OAT1	MESH:D005978	9356	Chemical	Gene	transport|amod|START_ENTITY responsible|nmod|transport responsible|nsubj|END_ENTITY	Human organic anion transporter OAT1 is not responsible for glutathione transport but mediates transport of glutamate derivatives .
17141510	0	glutathione	62,73	PARK6	88,93	glutathione	PARK6	MESH:D005978	65018	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|nmod|END_ENTITY	Mitochondrial_dysfunction , peroxidation damage and changes in glutathione metabolism in PARK6 .
12495372	0	glutathione	51,62	Part_1	35,41	glutathione	Part 1	MESH:D005978	25859	Chemical	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Mercury toxicity and antioxidants : Part_1 : role of glutathione and alpha-lipoic_acid in the treatment of mercury toxicity .
17223798	0	glutathione	77,88	Ser11	8,13	glutathione	Ser11	MESH:D005978	3190203(Tax:176280)	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of Ser11 in the stabilization of the structure of Ochrobactrum_anthropi glutathione transferase .
9784026	0	glutathione	146,157	TNF_alpha	133,142	glutathione	TNF alpha	MESH:D005978	7124	Chemical	Gene	synthesis|amod|START_ENTITY END_ENTITY|nmod|synthesis	Plasma levels of glutathione , alpha-tocopherol and lipid peroxides in polytraumatized patients ; evidence for a stimulating effect of TNF_alpha on glutathione synthesis .
9784026	0	glutathione	17,28	TNF_alpha	133,142	glutathione	TNF alpha	MESH:D005978	7124	Chemical	Gene	peroxides|compound|START_ENTITY levels|nmod|peroxides levels|dep|evidence evidence|nmod|effect effect|nmod|END_ENTITY	Plasma levels of glutathione , alpha-tocopherol and lipid peroxides in polytraumatized patients ; evidence for a stimulating effect of TNF_alpha on glutathione synthesis .
1958383	0	glutathione	91,102	Tumor_necrosis_factor	0,21	glutathione	Tumor necrosis factor	MESH:D005978	7124	Chemical	Gene	role|nmod|START_ENTITY enhances|parataxis|role enhances|nsubj|END_ENTITY	Tumor_necrosis_factor enhances endothelial cell susceptibility to oxygen toxicity : role of glutathione .
9374527	0	glutathione	47,58	Tumor_necrosis_factor	0,21	glutathione	Tumor necrosis factor	MESH:D005978	103694380	Chemical	Gene	increases|dobj|START_ENTITY increases|nsubj|END_ENTITY	Tumor_necrosis_factor increases hepatocellular glutathione by transcriptional regulation of the heavy subunit chain of gamma-glutamylcysteine_synthetase .
11695904	0	glutathione	78,89	Ure2p	38,43	glutathione	Ure2p	MESH:D005978	855492(Tax:4932)	Chemical	Gene	compounds|amod|START_ENTITY END_ENTITY|nmod|compounds	Crystal structures of the yeast prion Ure2p functional region in complex with glutathione and related compounds .
8070315	0	glutathione	38,49	Yc2	71,74	glutathione	Yc2	MESH:D005978	494500(Tax:10116)	Chemical	Gene	subunit|amod|START_ENTITY subunit|appos|END_ENTITY	Indole-3-carbinol induces a rat liver glutathione transferase subunit -LRB- Yc2 -RRB- with high activity toward aflatoxin_B1_exo-epoxide .
26194989	0	glutathione	19,30	acrosin	34,41	glutathione	acrosin	MESH:D005978	397098(Tax:9823)	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Effects of reduced glutathione on acrosin activity in frozen?thawed boar spermatozoa .
26194989	0	glutathione	19,30	acrosin	34,41	glutathione	acrosin	MESH:D005978	397098(Tax:9823)	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Effects of reduced glutathione on acrosin activity in frozen?thawed boar spermatozoa .
10420119	0	glutathione	32,43	catalase	22,30	glutathione	catalase	MESH:D005978	24248(Tax:10116)	Chemical	Gene	peroxidase|amod|START_ENTITY peroxidase|amod|END_ENTITY	Superoxide dismutase , catalase , glutathione peroxidase and xanthine oxidase in diabetic rat lenses .
11907164	0	glutathione	129,140	catalase	38,46	glutathione	catalase	MESH:D005978	847	Chemical	Gene	depletion|amod|START_ENTITY caused|nmod|depletion toxicity|acl|caused protects|nmod|toxicity protects|nsubj|overexpression overexpression|nmod|END_ENTITY	Adenovirus-mediated overexpression of catalase in the cytosolic or mitochondrial compartment protects against toxicity caused by glutathione depletion in HepG2 cells expressing CYP2E1 .
12472782	0	glutathione	32,43	catalase	22,30	glutathione	catalase	MESH:D005978	24248(Tax:10116)	Chemical	Gene	peroxidase|amod|START_ENTITY peroxidase|amod|END_ENTITY	Superoxide dismutase , catalase , glutathione peroxidase and NADPH oxidase in lead-induced hypertension .
14644473	0	glutathione	49,60	catalase	39,47	glutathione	catalase	MESH:D005978	24248(Tax:10116)	Chemical	Gene	peroxidase|amod|START_ENTITY peroxidase|amod|END_ENTITY	NAD -LRB- P -RRB- H oxidase , superoxide dismutase , catalase , glutathione peroxidase and nitric_oxide synthase expression in subacute spinal_cord_injury .
16257394	0	glutathione	84,95	catalase	68,76	glutathione	catalase	MESH:D005978	847	Chemical	Gene	peroxidase|amod|START_ENTITY differences|nmod|peroxidase differences|nmod|efficacy efficacy|nmod|therapy therapy|nmod|END_ENTITY	Marked differences in the efficacy of post-insult gene therapy with catalase versus glutathione peroxidase .
16664526	0	glutathione	15,26	catalase	65,73	glutathione	catalase	MESH:D005978	100037447(Tax:3847)	Chemical	Gene	synthesis|amod|START_ENTITY synthesis|acl|photorespiring photorespiring|nmod|inhibitors inhibitors|amod|END_ENTITY	Stimulation of glutathione synthesis in photorespiring plants by catalase inhibitors .
18649847	0	glutathione	81,92	catalase	23,31	glutathione	catalase	MESH:D005978	40048(Tax:7227)	Chemical	Gene	amount|nmod|START_ENTITY changes|appos|amount changes|nmod|END_ENTITY	Age-related changes in catalase , glutathione_reductase activities , the amount of glutathione in total body of oregon and vestigial Drosophila_melanogaster .
21094119	0	glutathione	111,122	catalase	80,88	glutathione	catalase	MESH:D005978	847	Chemical	Gene	measuring|dobj|START_ENTITY END_ENTITY|advcl|measuring	High-performance liquid chromatography ultraviolet assay for human erythrocytic catalase activity by measuring glutathione as o-phthalaldehyde derivative .
23096233	0	glutathione	47,58	catalase	16,24	glutathione	catalase	MESH:D005978	24248(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY END_ENTITY|nmod|activity	Upregulation of catalase and downregulation of glutathione peroxidase activity in the kidney precede the development of hypertension in pre-hypertensive SHR .
2386536	0	glutathione	77,88	catalase	67,75	glutathione	catalase	MESH:D005978	24248(Tax:10116)	Chemical	Gene	peroxidase|amod|START_ENTITY peroxidase|amod|END_ENTITY	Glutathione-S-transferase , superoxide dismutase , xanthine oxidase , catalase , glutathione peroxidase and lipid peroxidation in the liver of exercised rats .
2559882	0	glutathione	30,41	catalase	18,26	glutathione	catalase	MESH:D005978	847	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	The inhibition of catalase by glutathione .
2813285	0	glutathione	21,32	catalase	11,19	glutathione	catalase	MESH:D005978	847	Chemical	Gene	peroxidase|amod|START_ENTITY peroxidase|amod|END_ENTITY	Changes in catalase , glutathione peroxidase and glutathione-S-transferase activities in the liver of newts exposed to 2-methyl-4-chlorophenoxyacetic_acid -LRB- MCPA -RRB- .
3777154	0	glutathione	53,64	catalase	84,92	glutathione	catalase	MESH:D005978	847	Chemical	Gene	cycle|amod|START_ENTITY cycle|nmod|END_ENTITY	Antioxidant defense mechanisms of endothelial cells : glutathione redox cycle versus catalase .
3982082	0	glutathione	21,32	catalase	11,19	glutathione	catalase	MESH:D005978	847	Chemical	Gene	peroxidase|amod|START_ENTITY peroxidase|amod|END_ENTITY	Studies on catalase , glutathione peroxidase and superoxidismutase activities in aging cells of Paramecium tetraurelia .
8765690	1	glutathione	118,129	catalase	212,220	glutathione	catalase	MESH:D005978	24248(Tax:10116)	Chemical	Gene	copper-ions|dep|START_ENTITY copper-ions|amod|superoxide superoxide|amod|END_ENTITY	Kinetics and influence of ascorbic_acid , glutathione , dimethylsulfoxide , N-t-butyl-a-phenyl-nitrone , copper-ions and a copper complex , catalase , superoxide dismutase , hexobarbital and aniline .
6545072	0	glutathione	8,19	cholesterol_7_alpha-hydroxylase	49,80	glutathione	cholesterol 7 alpha-hydroxylase	MESH:D005978	25428(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|regulation regulation|nmod|END_ENTITY	Role of glutathione in the regulation of hepatic cholesterol_7_alpha-hydroxylase , the rate-limiting enzyme of bile_acid biosynthesis .
8347178	2	glutathione	59,70	cholesterol_7_alpha-hydroxylase	114,145	glutathione	cholesterol 7 alpha-hydroxylase	MESH:D005978	25428(Tax:10116)	Chemical	Gene	content|compound|START_ENTITY Effect|nmod|content Effect|nmod|END_ENTITY	Effect of hepatic glutathione content on the activity and mRNA levels of cholesterol_7_alpha-hydroxylase in the rat .
12874275	0	glutathione	134,145	connexin-43	113,124	glutathione	connexin-43	MESH:D005978	24392(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Epidermal_growth_factor_receptor is a common mediator of quinone-induced signaling leading to phosphorylation of connexin-43 : role of glutathione and tyrosine phosphatases .
17668203	0	glutathione	106,117	cyclooxygenase-2	40,56	glutathione	cyclooxygenase-2	MESH:D005978	5743	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|inhibitors inhibitors|amod|END_ENTITY	Cyclooxygenase-2 independent effects of cyclooxygenase-2 inhibitors on oxidative stress and intracellular glutathione content in normal and malignant human B-cells .
121071	0	glutathione	21,32	cytochrome_P-450	71,87	glutathione	cytochrome P-450	MESH:D005978	25251(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|inhibition inhibition|nmod|END_ENTITY	Protective effect of glutathione on the in vitro inhibition of hepatic cytochrome_P-450 by captan .
8391509	0	glutathione	47,58	cytochrome_c	31,43	glutathione	cytochrome c	MESH:D005978	54205	Chemical	Gene	reduction|nmod|START_ENTITY reduction|nmod|END_ENTITY	Sulfane-activated reduction of cytochrome_c by glutathione .
12897436	0	glutathione	65,76	gamma-glutamyl_transpeptidase	12,41	glutathione	gamma-glutamyl transpeptidase	MESH:D005978	92086	Chemical	Gene	biosynthesis|nmod|START_ENTITY role|nmod|biosynthesis role|nmod|END_ENTITY	The role of gamma-glutamyl_transpeptidase in the biosynthesis of glutathione .
15177451	0	glutathione	49,60	gamma-glutamyl_transpeptidase	92,121	glutathione	gamma-glutamyl transpeptidase	MESH:D005978	116568(Tax:10116)	Chemical	Gene	Synthesis|nmod|START_ENTITY Synthesis|nmod|END_ENTITY	Synthesis of S-alkyl_L-homocysteine analogues of glutathione and their kinetic studies with gamma-glutamyl_transpeptidase .
8105826	0	glutathione	60,71	gamma-glutamyl_transpeptidase	14,43	glutathione	gamma-glutamyl transpeptidase	MESH:D005978	92086	Chemical	Gene	START_ENTITY|nsubj|Activities Activities|nmod|END_ENTITY	Activities of gamma-glutamyl_transpeptidase and erythrocyte glutathione dependent enzymes in nasopharyngeal_carcinoma patients and normal controls .
10051436	0	glutathione	181,192	gamma-glutamylcysteine_synthetase	119,152	glutathione	gamma-glutamylcysteine synthetase	MESH:D005978	2729	Chemical	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Pyrrolidine_dithiocarbamate up-regulates the expression of the genes encoding the catalytic and regulatory subunits of gamma-glutamylcysteine_synthetase and increases intracellular glutathione levels .
10748080	0	glutathione	45,56	gamma-glutamylcysteine_synthetase	100,133	glutathione	gamma-glutamylcysteine synthetase	MESH:D005978	2729	Chemical	Gene	synthesis|amod|START_ENTITY induces|dobj|synthesis induces|nmod|activation activation|nmod|END_ENTITY	CYP2E1 overexpression in HepG2 cells induces glutathione synthesis by transcriptional activation of gamma-glutamylcysteine_synthetase .
10098886	0	glutathione	117,128	glucose-6-phosphate_dehydrogenase	13,46	glutathione	glucose-6-phosphate dehydrogenase	MESH:D005978	24377(Tax:10116)	Chemical	Gene	depletion|compound|START_ENTITY preventing|dobj|depletion contributes|advcl|preventing contributes|nsubj|Induction Induction|nmod|END_ENTITY	Induction of glucose-6-phosphate_dehydrogenase by lipopolysaccharide contributes to preventing nitric_oxide-mediated glutathione depletion in cultured rat astrocytes .
12547330	0	glutathione	105,116	glucose-6-phosphate_dehydrogenase	44,77	glutathione	glucose-6-phosphate dehydrogenase	MESH:D005978	2539	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|compounds compounds|nmod|cells cells|amod|END_ENTITY	Estrogenic effects of phenolic compounds on glucose-6-phosphate_dehydrogenase in MCF-7 cells and uterine glutathione peroxidase in rats .
3438059	0	glutathione	42,53	glucose-6-phosphate_dehydrogenase	99,132	glutathione	glucose-6-phosphate dehydrogenase	MESH:D005978	2539	Chemical	Gene	content|amod|START_ENTITY reduced|dobj|content reduced|nmod|deficiency deficiency|amod|END_ENTITY	Superoxide dismutase activity and reduced glutathione content in cataractous lens of patients with glucose-6-phosphate_dehydrogenase deficiency .
4087944	2	glutathione	76,87	glucose-6-phosphate_dehydrogenase	109,142	glutathione	glucose-6-phosphate dehydrogenase	MESH:D005978	2539	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|alteration alteration|nmod|END_ENTITY	Effect of glutathione on the alteration of glucose-6-phosphate_dehydrogenase .
4180961	0	glutathione	71,82	glucose-6-phosphate_dehydrogenase	86,119	glutathione	glucose-6-phosphate dehydrogenase	MESH:D005978	2539	Chemical	Gene	START_ENTITY|nmod|cells cells|amod|END_ENTITY	In-vitro-effect of a Fava Bean extract and of its fractions on reduced glutathione in glucose-6-phosphate_dehydrogenase deficient red cells .
5982880	0	glutathione	122,133	glucose-6-phosphate_dehydrogenase	59,92	glutathione	glucose-6-phosphate dehydrogenase	MESH:D005978	2539	Chemical	Gene	synthesis|amod|START_ENTITY erythrocytes|nmod|synthesis erythrocytes|nmod|deficiency deficiency|amod|END_ENTITY	-LSB- Heinz body formation and GSH content in erythrocytes with glucose-6-phosphate_dehydrogenase deficiency and disruption of glutathione synthesis after x-irradiation in vitro -RSB- .
8111051	0	glutathione	121,132	glucose-6-phosphate_dehydrogenase	42,75	glutathione	glucose-6-phosphate dehydrogenase	MESH:D005978	2539	Chemical	Gene	concentration|compound|START_ENTITY correlation|nmod|concentration damage|dep|correlation damage|acl|erythrocyte erythrocyte|dobj|membrane membrane|nmod|deficiency deficiency|amod|END_ENTITY	Oxidant damage to erythrocyte membrane in glucose-6-phosphate_dehydrogenase deficiency : correlation with in vivo reduced glutathione concentration and membrane protein oxidation .
8908366	0	glutathione	12,23	glucose-6-phosphate_dehydrogenase	58,91	glutathione	glucose-6-phosphate dehydrogenase	MESH:D005978	2539	Chemical	Gene	determination|amod|START_ENTITY Erythrocyte|dobj|determination Erythrocyte|nmod|diagnosis diagnosis|nmod|deficiency deficiency|amod|END_ENTITY	Erythrocyte glutathione determination in the diagnosis of glucose-6-phosphate_dehydrogenase deficiency .
9915806	0	glutathione	9,20	glucose-6-phosphate_dehydrogenase	70,103	glutathione	glucose-6-phosphate dehydrogenase	MESH:D005978	2539	Chemical	Gene	levels|compound|START_ENTITY mediated|nsubj|levels mediated|nmod|expression expression|amod|END_ENTITY	Enhanced glutathione levels and oxidoresistance mediated by increased glucose-6-phosphate_dehydrogenase expression .
12777768	0	glutathione	94,105	glutaredoxin	53,65	glutathione	glutaredoxin	MESH:D005978	2745	Chemical	Gene	studies|nmod|START_ENTITY studies|nmod|END_ENTITY	Crystallization and preliminary X-ray studies of the glutaredoxin from poplar in complex with glutathione .
10508391	0	glutathione	74,85	glutathione_S-transferase	30,55	glutathione	glutathione S-transferase	MESH:D005978	54486(Tax:10090)	Chemical	Gene	conjugate|amod|START_ENTITY complex|nmod|conjugate subunit|amod|complex END_ENTITY|nmod|subunit	Crystal structure of a murine glutathione_S-transferase in complex with a glutathione conjugate of 4-hydroxynon-2-enal in one subunit and glutathione in the other : evidence of signaling across the dimer interface .
11108808	1	glutathione	134,145	glutathione_S-transferase	100,125	glutathione	glutathione S-transferase	MESH:D005978	373156	Chemical	Gene	p1-1|nmod|START_ENTITY p1-1|amod|END_ENTITY	Inhibition of glutathione_S-transferase p1-1 by glutathione conjugates from anthracyclines .
12706373	0	glutathione	6,17	glutathione_S-transferase	57,82	glutathione	glutathione S-transferase	MESH:D005978	373156	Chemical	Gene	START_ENTITY|nmod|marker marker|nmod|activity activity|amod|END_ENTITY	Blood glutathione as a surrogate marker of cancer tissue glutathione_S-transferase activity in non-small_cell_lung_cancer and squamous_cell_carcinoma of the head_and_neck .
1287182	0	glutathione	72,83	glutathione_S-transferase	33,58	glutathione	glutathione S-transferase	MESH:D005978	58962(Tax:10116)	Chemical	Gene	depletor|amod|START_ENTITY rats|nmod|depletor END_ENTITY|nmod|rats	Activation of hepatic microsomal glutathione_S-transferase of rats by a glutathione depletor , diethylmaleate .
15032839	0	glutathione	85,96	glutathione_S-transferase	58,83	glutathione	glutathione S-transferase	MESH:D005978	373156	Chemical	Gene	peroxidase|amod|START_ENTITY peroxidase|amod|END_ENTITY	Abiotic stress alters transcript profiles and activity of glutathione_S-transferase , glutathione peroxidase , and glutathione_reductase in Euphorbia esula .
1567427	0	glutathione	111,122	glutathione_S-transferase	29,54	glutathione	glutathione S-transferase	MESH:D005978	373156	Chemical	Gene	group|nmod|START_ENTITY pKa|nmod|group lowering|dobj|pKa important|advcl|lowering important|nsubj|Tyrosine-7 Tyrosine-7|nmod|END_ENTITY	Tyrosine-7 in human class Pi glutathione_S-transferase is important for lowering the pKa of the thiol group of glutathione in the enzyme-glutathione complex .
1664313	0	glutathione	149,160	glutathione_S-transferase	12,37	glutathione	glutathione S-transferase	MESH:D005978	373156	Chemical	Gene	conjugation|nmod|START_ENTITY basis|nmod|conjugation purified|nmod|basis purified|nsubj|END_ENTITY	Recombinant glutathione_S-transferase -LRB- GST -RRB- expressing cells purified by flow cytometry on the basis of a GST-catalyzed intracellular conjugation of glutathione to monochlorobimane .
16773246	0	glutathione	67,78	glutathione_S-transferase	20,45	glutathione	glutathione S-transferase	MESH:D005978	373156	Chemical	Gene	affinity|nmod|START_ENTITY END_ENTITY|nmod|affinity	Identification of a glutathione_S-transferase without affinity for glutathione sepharose in human kidney .
18599958	0	glutathione	30,41	glutathione_S-transferase	65,90	glutathione	glutathione S-transferase	MESH:D005978	54486(Tax:10090)	Chemical	Gene	START_ENTITY|advcl|increasing increasing|dobj|activity activity|amod|END_ENTITY	S-adenosylmethionine mediates glutathione efficacy by increasing glutathione_S-transferase activity : implications for S-adenosyl_methionine as a neuroprotective dietary supplement .
20013880	0	glutathione	203,214	glutathione_S-transferase	70,95	glutathione	glutathione S-transferase	MESH:D005978	58962(Tax:10116)	Chemical	Gene	depletion|amod|START_ENTITY initiated|nmod|depletion signaling|acl|initiated partially|nmod|signaling partially|amod|END_ENTITY	Methionine restriction up-regulates the expression of the pi class of glutathione_S-transferase partially via the extracellular_signal-regulated_kinase-activator_protein-1 signaling pathway initiated by glutathione depletion .
2015603	0	glutathione	91,102	glutathione_S-transferase	42,67	glutathione	glutathione S-transferase	MESH:D005978	54486(Tax:10090)	Chemical	Gene	conjugation|nmod|START_ENTITY Specificity|nmod|conjugation Specificity|nmod|isozymes isozymes|nmod|END_ENTITY	Specificity of isozymes of murine hepatic glutathione_S-transferase for the conjugation of glutathione with L-phenylalanine mustard .
2230538	0	glutathione	71,82	glutathione_S-transferase	13,38	glutathione	glutathione S-transferase	MESH:D005978	373156	Chemical	Gene	transport|nmod|START_ENTITY transport|amod|END_ENTITY	Glutathione , glutathione_S-transferase , and transmembrane transport of glutathione conjugate in human neutrophil leukocytes .
2337897	0	glutathione	54,65	glutathione_S-transferase	27,52	glutathione	glutathione S-transferase	MESH:D005978	373156	Chemical	Gene	peroxidase|amod|START_ENTITY peroxidase|amod|END_ENTITY	Differential expression of glutathione_S-transferase , glutathione peroxidase and glutathione_reductase in normal and malignant human breast tissues .
2591193	0	glutathione	21,32	glutathione_S-transferase	69,94	glutathione	glutathione S-transferase	MESH:D005978	373156	Chemical	Gene	activity|compound|START_ENTITY associated|nsubj|activity associated|nmod|END_ENTITY	Selenium-independent glutathione peroxidase activity associated with glutathione_S-transferase from the housefly , Musca domestica .
2730917	0	glutathione	123,134	glutathione_S-transferase	48,73	glutathione	glutathione S-transferase	MESH:D005978	373156	Chemical	Gene	absence|nmod|START_ENTITY dinitrobenzene|nmod|absence inactivation|dep|dinitrobenzene inactivation|nmod|END_ENTITY	Site-directed inactivation of human lung acidic glutathione_S-transferase by 1-chloro-2 ,4 - dinitrobenzene in the absence of glutathione .
2742854	0	glutathione	61,72	glutathione_S-transferase	95,120	glutathione	glutathione S-transferase	MESH:D005978	58962(Tax:10116)	Chemical	Gene	anion|nmod|START_ENTITY evidence|nmod|anion evidence|nmod|site site|nmod|END_ENTITY	Spectroscopic and kinetic evidence for the thiolate anion of glutathione at the active site of glutathione_S-transferase .
2904809	0	glutathione	88,99	glutathione_S-transferase	35,60	glutathione	glutathione S-transferase	MESH:D005978	58962(Tax:10116)	Chemical	Gene	analogues|amod|START_ENTITY series|nmod|analogues isoenzymes|nmod|series isoenzymes|nsubj|specificity specificity|nmod|END_ENTITY	Substrate specificity of rat liver glutathione_S-transferase isoenzymes for a series of glutathione analogues , modified at the gamma-glutamyl moiety .
3954738	0	glutathione	143,154	glutathione_S-transferase	57,82	glutathione	glutathione S-transferase	MESH:D005978	373156	Chemical	Gene	concentrations|nmod|START_ENTITY ligand|nmod|concentrations ligand|xcomp|binding binding|nmod|END_ENTITY	Suppression of high-affinity ligand binding to the major glutathione_S-transferase from Galleria mellonella by physiological concentrations of glutathione .
3985965	0	glutathione	70,81	glutathione_S-transferase	108,133	glutathione	glutathione S-transferase	MESH:D005978	58962(Tax:10116)	Chemical	Gene	Synthesis|nmod|START_ENTITY Synthesis|nmod|inhibitors inhibitors|nmod|END_ENTITY	Synthesis and characterization of the oxygen and desthio analogues of glutathione as dead-end inhibitors of glutathione_S-transferase .
6138744	0	glutathione	38,49	glutathione_S-transferase	11,36	glutathione	glutathione S-transferase	MESH:D005978	373156	Chemical	Gene	peroxidase|amod|START_ENTITY peroxidase|amod|END_ENTITY	Studies on glutathione_S-transferase , glutathione peroxidase and glutathione_reductase in human normal and cataractous lenses .
6857674	0	glutathione	23,34	glutathione_S-transferase	90,115	glutathione	glutathione S-transferase	MESH:D005978	58962(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY activity|dep|association association|nmod|activity activity|amod|END_ENTITY	Non-selenium-dependent glutathione peroxidase activity in rat lung : association with lung glutathione_S-transferase activity and the effects of hyperoxia .
7201357	0	glutathione	43,54	glutathione_S-transferase	73,98	glutathione	glutathione S-transferase	MESH:D005978	58962(Tax:10116)	Chemical	Gene	Alterations|nmod|START_ENTITY Alterations|nmod|END_ENTITY	Alterations in hepatic and renal levels of glutathione and activities of glutathione_S-transferase from rats treated with cis-dichlorodiammineplatinum-II .
7712478	0	glutathione	75,86	glutathione_S-transferase	18,43	glutathione	glutathione S-transferase	MESH:D005978	373156	Chemical	Gene	conjugates|amod|START_ENTITY formation|nmod|conjugates role|nmod|formation role|nmod|isoenzymes isoenzymes|amod|END_ENTITY	The role of human glutathione_S-transferase isoenzymes in the formation of glutathione conjugates of the alkylating cytostatic drug thiotepa .
7728969	0	glutathione	100,111	glutathione_S-transferase	49,74	glutathione	glutathione S-transferase	MESH:D005978	373156	Chemical	Gene	concentrations|compound|START_ENTITY substrates|nmod|concentrations substrates|nsubj|rates rates|nmod|END_ENTITY	The high non-enzymatic conjugation rates of some glutathione_S-transferase -LRB- GST -RRB- substrates at high glutathione concentrations .
7954469	0	glutathione	114,125	glutathione_S-transferase	21,46	glutathione	glutathione S-transferase	MESH:D005978	373156	Chemical	Gene	metabolites|nmod|START_ENTITY metabolites|nsubj|Involvement Involvement|nmod|isoenzymes isoenzymes|amod|END_ENTITY	Involvement of human glutathione_S-transferase isoenzymes in the conjugation of cyclophosphamide metabolites with glutathione .
8261458	0	glutathione	14,25	glutathione_S-transferase	78,103	glutathione	glutathione S-transferase	MESH:D005978	373156	Chemical	Gene	START_ENTITY|ccomp|regulate regulate|dobj|induction induction|nmod|expression expression|amod|END_ENTITY	Intracellular glutathione levels regulate Fos/Jun induction and activation of glutathione_S-transferase gene expression .
8695367	0	glutathione	32,43	glutathione_S-transferase	59,84	glutathione	glutathione S-transferase	MESH:D005978	373156	Chemical	Gene	START_ENTITY|dobj|expression expression|amod|END_ENTITY	The relationship between tumour glutathione concentration , glutathione_S-transferase isoenzyme expression and response to single agent carboplatin in epithelial_ovarian_cancer patients .
8764997	0	glutathione	10,21	glutathione_S-transferase	113,138	glutathione	glutathione S-transferase	MESH:D005978	373156	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|stability stability|nmod|END_ENTITY	Effect of glutathione , glutathione_sulphonate and S-hexylglutathione on the conformational stability of class pi glutathione_S-transferase .
8799462	0	glutathione	79,90	glutathione_S-transferase	24,49	glutathione	glutathione S-transferase	MESH:D005978	58962(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY possess|dobj|activity possess|nsubj|isozymes isozymes|nmod|END_ENTITY	Alpha-class isozymes of glutathione_S-transferase in rat liver cytosol possess glutathione peroxidase activity toward phospholipid hydroperoxide .
8820431	0	glutathione	31,42	glutathione_S-transferase	59,84	glutathione	glutathione S-transferase	MESH:D005978	373156	Chemical	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of melphalan with glutathione and the role of glutathione_S-transferase .
11874473	0	glutathione	112,123	glutathione_reductase	18,39	glutathione	glutathione reductase	MESH:D005978	116686(Tax:10116)	Chemical	Gene	function|amod|START_ENTITY basis|nmod|function supports|dobj|basis supports|nsubj|expression expression|nmod|END_ENTITY	The expression of glutathione_reductase in the male reproductive system of rats supports the enzymatic basis of glutathione function in spermatogenesis .
14637279	0	glutathione	86,97	glutathione_reductase	24,45	glutathione	glutathione reductase	MESH:D005978	2936	Chemical	Gene	START_ENTITY|nsubj|peroxidase peroxidase|appos|activities activities|amod|END_ENTITY	Glutathione peroxidase , glutathione_reductase , Cu-Zn_superoxide dismutase activities , glutathione , nitric_oxide , and malondialdehyde concentrations in serum of patients with chronic_lymphocytic_leukemia .
17226929	0	glutathione	47,58	glutathione_reductase	140,161	glutathione	glutathione reductase	MESH:D005978	2936	Chemical	Gene	oxidation|nmod|START_ENTITY Kinetics|nmod|oxidation dimer|nsubj|Kinetics dimer|nmod|END_ENTITY	Kinetics and mechanism of the oxidation of the glutathione dimer by hypochlorous Acid and catalytic reduction of the chloroamine product by glutathione_reductase .
17498860	0	glutathione	64,75	glutathione_reductase	94,115	glutathione	glutathione reductase	MESH:D005978	2936	Chemical	Gene	depletion|nmod|START_ENTITY depletion|nmod|END_ENTITY	The interaction of chromium -LRB- VI -RRB- with macrophages : depletion of glutathione and inhibition of glutathione_reductase .
18371808	0	glutathione	24,35	glutathione_reductase	52,73	glutathione	glutathione reductase	MESH:D005978	2936	Chemical	Gene	detection|amod|START_ENTITY approach|nmod|detection approach|acl|using using|xcomp|END_ENTITY	Biosensing approach for glutathione detection using glutathione_reductase and sulfhydryl oxidase bienzymatic system .
18372516	0	glutathione	17,28	glutathione_reductase	30,51	glutathione	glutathione reductase	MESH:D005978	2936	Chemical	Gene	peroxidase|compound|START_ENTITY peroxidase|dep|END_ENTITY	Determination of glutathione , glutathione_reductase , glutathione peroxidase and glutathione_S-transferase levels in human lung_cancer tissues .
18372516	0	glutathione	53,64	glutathione_reductase	30,51	glutathione	glutathione reductase	MESH:D005978	2936	Chemical	Gene	peroxidase|dep|START_ENTITY peroxidase|dep|END_ENTITY	Determination of glutathione , glutathione_reductase , glutathione peroxidase and glutathione_S-transferase levels in human lung_cancer tissues .
18649847	0	glutathione	81,92	glutathione_reductase	33,54	glutathione	glutathione reductase	MESH:D005978	31760(Tax:7227)	Chemical	Gene	amount|nmod|START_ENTITY changes|appos|amount changes|appos|activities activities|amod|END_ENTITY	Age-related changes in catalase , glutathione_reductase activities , the amount of glutathione in total body of oregon and vestigial Drosophila_melanogaster .
22404488	0	glutathione	43,54	glutathione_reductase	114,135	glutathione	glutathione reductase	MESH:D005978	2936	Chemical	Gene	detection|nmod|START_ENTITY detection|nmod|form form|acl|using using|dobj|combination combination|nmod|END_ENTITY	Selective detection of the reduced form of glutathione -LRB- GSH -RRB- over the oxidized -LRB- GSSG -RRB- form using a combination of glutathione_reductase and a Tb -LRB- III -RRB- - cyclen_maleimide based lanthanide luminescent ` switch on ' assay .
22540111	0	glutathione	50,61	glutathione_reductase	74,95	glutathione	glutathione reductase	MESH:D005978	2936	Chemical	Gene	START_ENTITY|dobj|level level|amod|END_ENTITY	The effect of oxidative stress on human red cells glutathione peroxidase , glutathione_reductase level , and prevalence of anemia among diabetics .
2531483	0	glutathione	51,62	glutathione_reductase	64,85	glutathione	glutathione reductase	MESH:D005978	116686(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY -LSB-|nmod|activity -LSB-|dep|system system|amod|END_ENTITY	-LSB- The effect of nicotinamide on the activity of the glutathione - glutathione_reductase system in subcellular fractions of regenerating rat liver -RSB- .
2912729	0	glutathione	32,43	glutathione_reductase	60,81	glutathione	glutathione reductase	MESH:D005978	2936	Chemical	Gene	site|compound|START_ENTITY study|nmod|site study|nmod|END_ENTITY	A crystallographic study of the glutathione binding site of glutathione_reductase at 0.3-nm resolution .
7835406	0	glutathione	61,72	glutathione_reductase	38,59	glutathione	glutathione reductase	MESH:D005978	116686(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Levels Levels|nmod|expression expression|nmod|genes genes|nmod|END_ENTITY	Levels of expression of the genes for glutathione_reductase , glutathione peroxidase , catalase and CuZn-superoxide_dismutase in rat lens and liver .
8060317	0	glutathione	40,51	glutathione_reductase	55,76	glutathione	glutathione reductase	MESH:D005978	2936	Chemical	Gene	derivative|nmod|START_ENTITY Reduction|nmod|derivative Reduction|nmod|END_ENTITY	Reduction of a trisulfide derivative of glutathione by glutathione_reductase .
8580767	0	glutathione	33,44	glutathione_reductase	48,69	glutathione	glutathione reductase	MESH:D005978	2936	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Differential redox regulation by glutathione of glutathione_reductase and CuZn-superoxide_dismutase gene expression in Pinus sylvestris L. needles .
8738227	0	glutathione	19,30	glutathione_reductase	56,77	glutathione	glutathione reductase	MESH:D005978	116686(Tax:10116)	Chemical	Gene	results|compound|START_ENTITY results|nmod|decrease decrease|nmod|activity activity|amod|END_ENTITY	Depletion of brain glutathione results in a decrease of glutathione_reductase activity ; an enzyme susceptible to oxidative damage .
9508091	0	glutathione	77,88	glutathione_reductase	12,33	glutathione	glutathione reductase	MESH:D005978	2936	Chemical	Gene	system|amod|START_ENTITY reveals|nmod|system reveals|nsubj|activity activity|compound|END_ENTITY	Human sperm glutathione_reductase activity in situ reveals limitation in the glutathione antioxidant defense system due to supply of NADPH .
14561132	0	glutathione	18,29	glutathione_s-transferase	55,80	glutathione	glutathione s-transferase	MESH:D005978	373156	Chemical	Gene	residues|amod|START_ENTITY roles|nmod|residues roles|nmod|END_ENTITY	Multiple roles of glutathione binding-site residues of glutathione_s-transferase .
11747461	0	glutathione	56,67	glutathione_transferase_A1-1	104,132	glutathione	glutathione transferase A1-1	MESH:D005978	2938	Chemical	Gene	START_ENTITY|nmod|mechanism mechanism|nmod|END_ENTITY	Role of the glutamyl_alpha-carboxylate of the substrate glutathione in the catalytic mechanism of human glutathione_transferase_A1-1 .
7138835	0	glutathione	74,85	glyoxalase_I	125,137	glutathione	glyoxalase I	MESH:D005978	2739	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Fluorescence and nuclear relaxation enhancement studies of the binding of glutathione derivatives to manganese-reconstituted glyoxalase_I from human erythrocytes .
3955057	0	glutathione	14,25	glyoxalase_II	54,67	glutathione	glyoxalase II	MESH:D005978	509274(Tax:9913)	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Inhibition by glutathione derivatives of bovine liver glyoxalase_II -LRB- hydroxyacylglutathione_hydrolase -RRB- as a probe of the N - and S-sites for substrate binding .
12966434	0	glutathione	61,72	growth_hormone	42,56	glutathione	growth hormone	MESH:D005978	2688	Chemical	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	Potentiation of tumour apoptosis by human growth_hormone via glutathione production and decreased NF-kappaB activity .
24534356	0	glutathione	12,23	heat_shock_protein_70	34,55	glutathione	heat shock protein 70	MESH:D005978	266759(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of glutathione on plasma heat_shock_protein_70 of acute gastric mucosal_injury in rats exposed to positive acceleration -RSB- .
10544272	0	glutathione	13,24	hepatocyte_growth_factor	53,77	glutathione	hepatocyte growth factor	MESH:D005978	24446(Tax:10116)	Chemical	Gene	level|amod|START_ENTITY Elevation|nmod|level hepatocytes|nsubj|Elevation hepatocytes|nmod|END_ENTITY	Elevation of glutathione level in rat hepatocytes by hepatocyte_growth_factor via induction of gamma-glutamylcysteine_synthetase .
17950727	0	glutathione	39,50	hepatocyte_growth_factor	11,35	glutathione	hepatocyte growth factor	MESH:D005978	3082	Chemical	Gene	synthesis|amod|START_ENTITY END_ENTITY|nmod|synthesis	Effects of hepatocyte_growth_factor on glutathione synthesis , growth , and apoptosis is cell density-dependent .
6968593	0	glutathione	31,42	hexokinase	68,78	glutathione	hexokinase	MESH:D005978	100338214(Tax:9986)	Chemical	Gene	Action|nmod|START_ENTITY END_ENTITY|nsubj|Action	Action of oxidized and reduced glutathione on rabbit red blood cell hexokinase .
1556108	0	glutathione	93,104	hgpx1	122,127	glutathione	hgpx1	MESH:D005978	2876	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Structure and function of the 5 ' - flanking sequence of the human cytosolic selenium-dependent glutathione peroxidase gene -LRB- hgpx1 -RRB- .
10403520	0	glutathione	15,26	hsp72	30,35	glutathione	hsp72	MESH:D005978	3303	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Attenuation by glutathione of hsp72 gene expression induced by cadmium in cisplatin-resistant human ovarian_cancer cells .
10730821	0	glutathione	55,66	iNOS	14,18	glutathione	iNOS	MESH:D005978	4843	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|levels levels|amod|END_ENTITY	Regulation of iNOS mRNA levels in endothelial cells by glutathione , a double-edged sword .
11396485	0	glutathione	34,45	interleukin-1	17,30	glutathione	interleukin-1	MESH:D005978	3552	Chemical	Gene	oxidation|amod|START_ENTITY END_ENTITY|nmod|oxidation	Is the effect of interleukin-1 on glutathione oxidation in cultured human fibroblasts involved in nuclear factor-kappaB activation ?
15185872	0	glutathione	34,45	interleukin_18	18,32	glutathione	interleukin 18	MESH:D005978	3606	Chemical	Gene	peroxidase|amod|START_ENTITY peroxidase|amod|END_ENTITY	The importance of interleukin_18 , glutathione peroxidase , and selenium concentration changes in acute_pancreatitis .
16100899	0	glutathione	36,47	lecithin-cholesterol_acyltransferase	79,115	glutathione	lecithin-cholesterol acyltransferase	MESH:D005978	24530(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|amod|END_ENTITY	-LSB- Lipid-mobilizing effect of reduced glutathione and its intensifying action on lecithin-cholesterol_acyltransferase activity in blood serum of rats -RSB- .
11448450	0	glutathione	21,32	multidrug_resistance-associated_protein	50,89	glutathione	multidrug resistance-associated protein	MESH:D005978	8714	Chemical	Gene	transport|compound|START_ENTITY transport|nmod|END_ENTITY	Verapamil-stimulated glutathione transport by the multidrug_resistance-associated_protein -LRB- MRP1 -RRB- in leukaemia cells .
16679408	0	glutathione	80,91	multidrug_resistance-associated_protein_1	103,144	glutathione	multidrug resistance-associated protein 1	MESH:D005978	4363	Chemical	Gene	efflux|compound|START_ENTITY efflux|nmod|END_ENTITY	Nitrogen_monoxide -LRB- NO -RRB- - mediated iron release from cells is linked to NO-induced glutathione efflux via multidrug_resistance-associated_protein_1 .
17594942	0	glutathione	58,69	nerve_growth_factor	9,28	glutathione	nerve growth factor	MESH:D005978	18049(Tax:10090)	Chemical	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Role for nerve_growth_factor in the in vivo regulation of glutathione in response to LPS in mice .
7901332	0	glutathione	52,63	nerve_growth_factor	8,27	glutathione	nerve growth factor	MESH:D005978	310738(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY Role|dep|metabolism Role|nmod|END_ENTITY	Role of nerve_growth_factor in oxidant homeostasis : glutathione metabolism .
7973799	0	glutathione	91,102	neurotensin	26,37	glutathione	neurotensin	MESH:D005978	67405(Tax:10090)	Chemical	Gene	effect|acl|START_ENTITY effect|nmod|END_ENTITY	-LSB- Cytoprotective effect of neurotensin on acetaminophen induced liver_injury in relation to glutathione system -RSB- .
17719021	0	glutathione	85,96	organic_anion_transporter_3	12,39	glutathione	organic anion transporter 3	MESH:D005978	83500(Tax:10116)	Chemical	Gene	transport|nmod|START_ENTITY Role|nmod|transport Role|nmod|END_ENTITY	Role of rat organic_anion_transporter_3 -LRB- Oat3 -RRB- in the renal basolateral transport of glutathione .
11167962	0	glutathione	14,25	p38	73,76	glutathione	p38	MESH:D005978	1432	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|amod|END_ENTITY	Intracellular glutathione regulates tumour_necrosis_factor-alpha-induced p38 MAP kinase activation and RANTES production by human bronchial epithelial cells .
18573614	0	glutathione	54,65	p38	85,88	glutathione	p38	MESH:D005978	81649(Tax:10116)	Chemical	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Cadmium specifically induces MKP-1 expression via the glutathione depletion-mediated p38 MAPK activation in C6 glioma cells .
17854349	0	glutathione	53,64	peroxisome_proliferator_activated_receptor_delta	93,141	glutathione	peroxisome proliferator activated receptor delta	MESH:D005978	25682(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY effects|nmod|synthesis effects|nmod|END_ENTITY	Neuroprotective actions of noradrenaline : effects on glutathione synthesis and activation of peroxisome_proliferator_activated_receptor_delta .
12940695	0	glutathione	34,45	superoxide_dismutase	12,32	glutathione	superoxide dismutase	MESH:D005978	6647	Chemical	Gene	peroxidase|amod|START_ENTITY peroxidase|amod|END_ENTITY	Erythrocyte superoxide_dismutase , glutathione peroxidase and catalase activities in healthy male subjects in Republic of Macedonia .
16521948	0	glutathione	37,48	superoxide_dismutase	15,35	glutathione	superoxide dismutase	MESH:D005978	6647	Chemical	Gene	peroxidase|amod|START_ENTITY peroxidase|amod|END_ENTITY	-LSB- Activities of superoxide_dismutase , glutathione peroxidase and catalase in erythrocytes of women smoking during pregnancy -RSB- .
16708815	0	glutathione	114,125	superoxide_dismutase	92,112	glutathione	superoxide dismutase	MESH:D005978	6647	Chemical	Gene	peroxidase|amod|START_ENTITY peroxidase|amod|END_ENTITY	-LSB- Advanced oxidation protein products in diabetic_nephropathy patients and its relation with superoxide_dismutase , glutathione peroxidase , neopterin -RSB- .
23095458	0	glutathione	36,47	superoxide_dismutase	14,34	glutathione	superoxide dismutase	MESH:D005978	6647	Chemical	Gene	peroxidase|amod|START_ENTITY peroxidase|amod|END_ENTITY	Comparison of superoxide_dismutase , glutathione peroxidase and adenosine_deaminase activities between respiratory and nocturnal subtypes of patients with panic_disorder .
27003969	0	glutathione	74,85	superoxide_dismutase	52,72	glutathione	superoxide dismutase	MESH:D005978	6647	Chemical	Gene	peroxidase|amod|START_ENTITY peroxidase|amod|END_ENTITY	Preventive -LRB- myoglobin , transferrin -RRB- and scavenging -LRB- superoxide_dismutase , glutathione peroxidase -RRB- anti-oxidative properties of raw liquid extract of Morinda lucida leaf in the traditional treatment of Plasmodium infection .
18384530	0	glutathione	17,28	tumor_necrosis_factor	57,78	glutathione	tumor necrosis factor	MESH:D005978	7124	Chemical	Gene	START_ENTITY|nmod|enhancement enhancement|nmod|END_ENTITY	Critical role of glutathione in melatonin enhancement of tumor_necrosis_factor and ionizing radiation-induced apoptosis in prostate_cancer cells in vitro .
2172172	0	glutathione	37,48	tumor_necrosis_factor	91,112	glutathione	tumor necrosis factor	MESH:D005978	7124	Chemical	Gene	START_ENTITY|nmod|production production|acl|induced induced|nmod|END_ENTITY	Suppressive effects of intracellular glutathione on hydroxyl radical production induced by tumor_necrosis_factor .
2354175	0	glutathione_disulfide	30,51	glutathione_reductase	72,93	glutathione disulfide	glutathione reductase	MESH:D019803	2936	Chemical	Gene	START_ENTITY|nmod|catalysis catalysis|nmod|END_ENTITY	Role of the charged groups of glutathione_disulfide in the catalysis of glutathione_reductase : crystallographic and kinetic studies with synthetic analogues .
8174544	0	glutathione_disulphide	20,42	nuclear_transcription_factor_kappa_B	50,86	glutathione disulphide	nuclear transcription factor kappa B	CHEBI:17858	18033(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Distinct effects of glutathione_disulphide on the nuclear_transcription_factor_kappa_B and the activator_protein-1 .
9426231	0	glutathione_prostaglandin_A	13,40	multidrug_resistance_protein_1	59,89	glutathione prostaglandin A	multidrug resistance protein 1	null	18669(Tax:10090)	Chemical	Gene	Transport|nmod|START_ENTITY conjugates|nsubj|Transport conjugates|nmod|END_ENTITY	Transport of glutathione_prostaglandin_A conjugates by the multidrug_resistance_protein_1 .
2559356	0	glyburide	94,103	Insulin	0,7	glyburide	Insulin	MESH:D005905	3630	Chemical	Gene	produced|nmod|START_ENTITY mRNA|acl|produced increases|nmod|mRNA receptors|dep|increases receptors|compound|END_ENTITY	Insulin and IGF-I receptors in neuroblastoma cells : increases in mRNA and binding produced by glyburide .
1954808	0	glyburide	26,35	insulin	39,46	glyburide	insulin	MESH:D005905	3630	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Dose-dependent effects of glyburide on insulin secretion and glucose uptake in humans .
2105434	0	glyburide	38,47	insulin	86,93	glyburide	insulin	MESH:D005905	280829(Tax:9913)	Chemical	Gene	effects|nmod|START_ENTITY Studies|nmod|effects Studies|dep|comparisons comparisons|nmod|END_ENTITY	Studies of antiproteolytic effects of glyburide on rat L6 myoblasts : comparisons with insulin .
2132401	0	glyburide	77,86	insulin	45,52	glyburide	insulin	MESH:D005905	3630	Chemical	Gene	treatment|amod|START_ENTITY Recovery|nmod|treatment Recovery|nmod|Effect Effect|nmod|defects defects|compound|END_ENTITY	Recovery of Staub Effect and amelioration of insulin secretion defects after glyburide treatment in non-insulin-dependent_diabetes .
3117833	0	glyburide	16,25	insulin	29,36	glyburide	insulin	MESH:D005905	3630	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|sensitivity sensitivity|compound|END_ENTITY	Acute effect of glyburide on insulin sensitivity in type I diabetic patients .
7926425	0	glyburide	53,62	insulin	24,31	glyburide	insulin	MESH:D005905	3630	Chemical	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	-LSB- A comparative study of insulin and glyburide versus glyburide or insulin in the chronic control of patients with type-2 diabetes -RSB- .
10377238	0	glyceraldehyde-3-phosphate	42,68	GAPDH	84,89	glyceraldehyde-3-phosphate	GAPDH	MESH:D005986	2597	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	Acyl phosphatase activity of NO-inhibited glyceraldehyde-3-phosphate dehydrogenase -LRB- GAPDH -RRB- : a potential mechanism for uncoupling glycolysis from ATP generation in NO-producing cells .
21546586	0	glyceraldehyde-3-phosphate	30,56	GAPDH	72,77	glyceraldehyde-3-phosphate	GAPDH	MESH:D005986	2597	Chemical	Gene	dehydrogenase|amod|START_ENTITY Role|nmod|dehydrogenase Role|appos|END_ENTITY	Role of Mycoplasma_pneumoniae glyceraldehyde-3-phosphate dehydrogenase -LRB- GAPDH -RRB- in mediating interactions with the human extracellular matrix .
25742975	0	glyceraldehyde-3-phosphate	20,46	GAPDH	62,67	glyceraldehyde-3-phosphate	GAPDH	MESH:D005986	24383(Tax:10116)	Chemical	Gene	dehydrogenase|amod|START_ENTITY efficacy|nmod|dehydrogenase efficacy|appos|END_ENTITY	Vaccine efficacy of glyceraldehyde-3-phosphate dehydrogenase -LRB- GAPDH -RRB- from Edwardsiella_ictaluri against E. _ tarda in tilapia .
20828617	0	glyceraldehyde-3-phosphate	33,59	GAPDHS	75,81	glyceraldehyde-3-phosphate	GAPDHS	MESH:D005986	26330	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	Recombinant human sperm-specific glyceraldehyde-3-phosphate dehydrogenase -LRB- GAPDHS -RRB- is expressed at high yield as an active homotetramer in baculovirus-infected insect cells .
14652693	0	glyceraldehyde-3-phosphate	97,123	TDH1	139,143	glyceraldehyde-3-phosphate	TDH1	MESH:D005986	853395(Tax:4932)	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	NADH-reductive stress in Saccharomyces_cerevisiae induces the expression of the minor isoform of glyceraldehyde-3-phosphate dehydrogenase -LRB- TDH1 -RRB- .
10864658	0	glyceraldehyde_3-phosphate	73,99	GAPDH	115,120	glyceraldehyde 3-phosphate	GAPDH	MESH:D005986	2597	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	Functional significance of the interaction of hepatitis_A virus RNA with glyceraldehyde_3-phosphate dehydrogenase -LRB- GAPDH -RRB- : opposing effects of GAPDH and polypyrimidine tract binding protein on internal ribosome entry site function .
25065746	0	glyceraldehyde_3-phosphate	4,30	GAPDH	51,56	glyceraldehyde 3-phosphate	GAPDH	MESH:D005986	2597	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The glyceraldehyde_3-phosphate dehydrogenase gene -LRB- GAPDH -RRB- is regulated by myeloid_zinc_finger_1 -LRB- MZF-1 -RRB- and is induced by calcitriol .
25176140	0	glyceraldehyde_3-phosphate	56,82	GAPDH	98,103	glyceraldehyde 3-phosphate	GAPDH	MESH:D005986	786101(Tax:9913)	Chemical	Gene	dehydrogenase|amod|START_ENTITY structures|nmod|dehydrogenase structures|appos|END_ENTITY	High-resolution crystal structures of the photoreceptor glyceraldehyde_3-phosphate dehydrogenase -LRB- GAPDH -RRB- with three and four-bound NAD molecules .
16700075	0	glyceraldehyde_3-phosphate	46,72	GAPDS	88,93	glyceraldehyde 3-phosphate	GAPDS	MESH:D005986	24383(Tax:10116)	Chemical	Gene	dehydrogenase|amod|START_ENTITY Expression|nmod|dehydrogenase Expression|appos|END_ENTITY	Expression of the spermatogenic cell-specific glyceraldehyde_3-phosphate dehydrogenase -LRB- GAPDS -RRB- in rat testis .
1591341	0	glyceraldehyde_3-phosphate	52,78	Gapd-s	94,100	glyceraldehyde 3-phosphate	Gapd-s	MESH:D005986	14447(Tax:10090)	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	In situ localization of spermatogenic cell-specific glyceraldehyde_3-phosphate dehydrogenase -LRB- Gapd-s -RRB- messenger ribonucleic acid in mice .
7736666	0	glyceraldehyde_3-phosphate	32,58	Gapd-s	79,85	glyceraldehyde 3-phosphate	Gapd-s	MESH:D005986	14447(Tax:10090)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic organization of a mouse glyceraldehyde_3-phosphate dehydrogenase gene -LRB- Gapd-s -RRB- expressed in post-meiotic spermatogenic cells .
7891898	0	glyceraldehyde_3-phosphate	13,39	Gapdh	55,60	glyceraldehyde 3-phosphate	Gapdh	MESH:D005986	14433(Tax:10090)	Chemical	Gene	dehydrogenase|amod|START_ENTITY cDNA|amod|dehydrogenase cDNA|appos|END_ENTITY	Isolation of glyceraldehyde_3-phosphate dehydrogenase -LRB- Gapdh -RRB- cDNA from the distal half of mouse chromosome 16 : further indication of a link between Alzheimer 's _ disease and glycolysis .
11231003	0	glycerol	15,23	Aquaporin_3	0,11	glycerol	Aquaporin 3	MESH:D005990	11828(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|appos|transporter	Aquaporin_3 , a glycerol and water transporter , is regulated by p73 of the p53 family .
16009937	0	glycerol	95,103	Aquaporin_7	0,11	glycerol	Aquaporin 7	MESH:D005990	11832(Tax:10090)	Chemical	Gene	kinase|amod|START_ENTITY activation|nmod|kinase associated|nmod|activation associated|nsubjpass|deficiency deficiency|amod|END_ENTITY	Aquaporin_7 deficiency is associated with development of obesity through activation of adipose glycerol kinase .
17576812	0	glycerol	63,71	Aquaporin_7	0,11	glycerol	Aquaporin 7	MESH:D005990	11832(Tax:10090)	Chemical	Gene	content|compound|START_ENTITY protein|nmod|content protein|nsubj|END_ENTITY	Aquaporin_7 is a_beta-cell protein and regulator of intraislet glycerol content and glycerol kinase activity , beta-cell mass , and insulin production and secretion .
21130427	0	glycerol	77,85	Aquaporin_7	0,11	glycerol	Aquaporin 7	MESH:D005990	11832(Tax:10090)	Chemical	Gene	transport|amod|START_ENTITY role|nmod|transport expression|dep|role expression|amod|END_ENTITY	Aquaporin_7 expression in postimplantation mouse uteri : a potential role for glycerol transport in uterine decidualization .
17636116	0	glycerol	37,45	Aquaporin_9	0,11	glycerol	Aquaporin 9	MESH:D005990	64008(Tax:10090)	Chemical	Gene	uptake|amod|START_ENTITY pathway|nmod|uptake pathway|nsubj|END_ENTITY	Aquaporin_9 is the major pathway for glycerol uptake by mouse erythrocytes , with implications for malarial virulence .
21656696	0	glycerol	48,56	CO2	60,63	glycerol	CO2	MESH:D005990	717	Chemical	Gene	transfer|nmod|START_ENTITY transfer|nmod|END_ENTITY	Ru -LRB- II -RRB- - mediated hydrogen transfer from aqueous glycerol to CO2 : from waste to value-added products .
12392719	0	glycerol	14,22	CYP11A1	46,53	glycerol	CYP11A1	MESH:D005990	1583	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of glycerol on cytochrome_P450scc -LRB- CYP11A1 -RRB- spin state , activity , and hydration .
15509855	0	glycerol	33,41	CrMIP1	90,96	glycerol	CrMIP1	MESH:D005990	5719640(Tax:3055)	Chemical	Gene	activity|amod|START_ENTITY identification|nmod|activity identification|nmod|END_ENTITY	Functional identification of the glycerol transport activity of Chlamydomonas_reinhardtii CrMIP1 .
12702345	0	glycerol	66,74	FPS1	16,20	glycerol	FPS1	MESH:D005990	850683(Tax:4932)	Chemical	Gene	efflux|amod|START_ENTITY content|nmod|efflux ergosterol|xcomp|content ergosterol|nsubj|Implications Implications|nmod|deletion deletion|compound|END_ENTITY	Implications of FPS1 deletion and membrane ergosterol content for glycerol efflux from Saccharomyces_cerevisiae .
24298058	1	glycerol	160,168	Fps1	136,140	glycerol	Fps1	MESH:D005990	850683(Tax:4932)	Chemical	Gene	transport|amod|START_ENTITY responsible|nmod|transport responsible|nsubj|END_ENTITY	The aquaglyceroprin Fps1 is responsible for glycerol transport in yeast in response to changes in extracellular osmolarity .
7729414	0	glycerol	81,89	Fps1	0,4	glycerol	Fps1	MESH:D005990	850683(Tax:4932)	Chemical	Gene	uptake|amod|START_ENTITY facilitator|nmod|uptake facilitator|nsubj|END_ENTITY	Fps1 , a yeast member of the MIP family of channel proteins , is a facilitator for glycerol uptake and efflux and is inactive under osmotic stress .
8358828	0	glycerol	4,12	GUT1	21,25	glycerol	GUT1	MESH:D005990	856353(Tax:4932)	Chemical	Gene	kinase|amod|START_ENTITY gene|amod|kinase gene|appos|END_ENTITY	The glycerol kinase -LRB- GUT1 -RRB- gene of Saccharomyces_cerevisiae : cloning and characterization .
11058591	0	glycerol	10,18	Gpp1p	34,39	glycerol	Gpp1p	MESH:D005990	854758(Tax:4932)	Chemical	Gene	START_ENTITY|ccomp|required required|nsubjpass|END_ENTITY	The yeast glycerol 3-phosphatases Gpp1p and Gpp2p are required for glycerol biosynthesis and differentially involved in the cellular responses to osmotic , anaerobic , and oxidative stress .
11058591	0	glycerol	67,75	Gpp1p	34,39	glycerol	Gpp1p	MESH:D005990	854758(Tax:4932)	Chemical	Gene	biosynthesis|amod|START_ENTITY required|nmod|biosynthesis required|nsubjpass|END_ENTITY	The yeast glycerol 3-phosphatases Gpp1p and Gpp2p are required for glycerol biosynthesis and differentially involved in the cellular responses to osmotic , anaerobic , and oxidative stress .
22057190	0	glycerol	74,82	Gr64e	52,57	glycerol	Gr64e	MESH:D005990	3771916(Tax:7227)	Chemical	Gene	receptor|nmod|START_ENTITY END_ENTITY|appos|receptor	Evolutionary differences in food preference rely on Gr64e , a receptor for glycerol .
17220467	0	glycerol	54,62	Mpk1p	176,181	glycerol	Mpk1p	MESH:D005990	856425(Tax:4932)	Chemical	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	Cdc37p is required for stress-induced high-osmolarity glycerol and protein kinase C mitogen-activated protein kinase pathway functionality by interaction with Hog1p and Slt2p -LRB- Mpk1p -RRB- .
11007982	0	glycerol	33,41	NLM1	84,88	glycerol	NLM1	MESH:D005990	827641(Tax:3702)	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Functional identification of the glycerol permease activity of Arabidopsis_thaliana NLM1 and NLM2 proteins by heterologous expression in Saccharomyces_cerevisiae .
26846624	0	glycerol	36,44	Pub1p	20,25	glycerol	Pub1p	MESH:D005990	855716(Tax:4932)	Chemical	Gene	production|amod|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	RNA binding protein Pub1p regulates glycerol production and stress tolerance by controlling Gpd1p activity during winemaking .
68762	0	glycerol	47,55	alcohol_dehydrogenase	18,39	glycerol	alcohol dehydrogenase	MESH:D005990	78959(Tax:10116)	Chemical	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	Role of rat-liver alcohol_dehydrogenase in the glycerol pathway to L-lactate in homogenates .
20862513	0	glycerol	25,33	aldehyde_dehydrogenase	69,91	glycerol	aldehyde dehydrogenase	MESH:D005990	17035736	Chemical	Gene	metabolism|amod|START_ENTITY Stimulation|nmod|metabolism Stimulation|nmod|END_ENTITY	Stimulation of reductive glycerol metabolism by overexpression of an aldehyde_dehydrogenase in a recombinant Klebsiella_pneumoniae_strain defective in the oxidative pathway .
17566090	0	glycerol	33,41	aquaporin-7	50,61	glycerol	aquaporin-7	MESH:D005990	364	Chemical	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Adipose tissue expression of the glycerol channel aquaporin-7 gene is altered in severe obesity but not in type 2 diabetes .
19096781	0	glycerol	39,47	aquaporin-7	8,19	glycerol	aquaporin-7	MESH:D005990	364	Chemical	Gene	metabolism|amod|START_ENTITY Role|nmod|metabolism Role|acl|END_ENTITY	Role of aquaporin-7 and aquaporin-9 in glycerol metabolism ; involvement in obesity .
15591341	0	glycerol	25,33	aquaporin_7	52,63	glycerol	aquaporin 7	MESH:D005990	11832(Tax:10090)	Chemical	Gene	transport|amod|START_ENTITY fasting|nmod|transport fasting|nmod|END_ENTITY	Adaptation to fasting by glycerol transport through aquaporin_7 in adipose tissue .
17351148	0	glycerol	38,46	aquaporin_7	55,66	glycerol	aquaporin 7	MESH:D005990	364	Chemical	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	A functional variant of the adipocyte glycerol channel aquaporin_7 gene is associated with obesity and related metabolic_abnormalities .
18852723	0	glycerol	40,48	aquaporin_7	58,69	glycerol	aquaporin 7	MESH:D005990	364	Chemical	Gene	channels|compound|START_ENTITY impact|nmod|channels impact|amod|END_ENTITY	Metabolic impact of adipose and hepatic glycerol channels aquaporin_7 and aquaporin_9 .
19297367	0	glycerol	19,27	aquaporin_7	59,70	glycerol	aquaporin 7	MESH:D005990	11832(Tax:10090)	Chemical	Gene	requires|xcomp|START_ENTITY requires|nmod|END_ENTITY	The heart requires glycerol as an energy substrate through aquaporin_7 , a glycerol facilitator .
19297367	0	glycerol	74,82	aquaporin_7	59,70	glycerol	aquaporin 7	MESH:D005990	11832(Tax:10090)	Chemical	Gene	facilitator|amod|START_ENTITY END_ENTITY|appos|facilitator	The heart requires glycerol as an energy substrate through aquaporin_7 , a glycerol facilitator .
24334538	0	glycerol	60,68	aquaporin_7	30,41	glycerol	aquaporin 7	MESH:D005990	364	Chemical	Gene	carrier|amod|START_ENTITY characteristics|nmod|carrier characteristics|nmod|END_ENTITY	Functional characteristics of aquaporin_7 as a facilitative glycerol carrier .
17360690	0	glycerol	10,18	aquaporin_9	33,44	glycerol	aquaporin 9	MESH:D005990	64008(Tax:10090)	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|nmod|END_ENTITY	Defective glycerol metabolism in aquaporin_9 -LRB- AQP9 -RRB- knockout mice .
18762715	0	glycerol	67,75	aquaporin_9	37,48	glycerol	aquaporin 9	MESH:D005990	366	Chemical	Gene	carrier|amod|START_ENTITY characterization|nmod|carrier characterization|nmod|END_ENTITY	Functional characterization of human aquaporin_9 as a facilitative glycerol carrier .
21294757	0	glycerol	38,46	aquaporin_9	84,95	glycerol	aquaporin 9	MESH:D005990	65054(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY acetaldehyde|nmod|uptake Effects|nmod|acetaldehyde Effects|dep|implication implication|nmod|END_ENTITY	Effects of acetaldehyde on hepatocyte glycerol uptake and cell size : implication of aquaporin_9 .
10744740	0	glycerol	42,50	atp1-2	65,71	glycerol	atp1-2	MESH:D005990	853259(Tax:4932)	Chemical	Gene	START_ENTITY|acl|caused caused|nmod|mutation mutation|amod|END_ENTITY	ASC1/RAS2 suppresses the growth defect on glycerol caused by the atp1-2 mutation in the yeast Saccharomyces_cerevisiae .
8857190	0	glycerol	11,19	beta-lactamase	23,37	glycerol	beta-lactamase	MESH:D005990	7872529(Tax:562)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|production production|amod|END_ENTITY	Effects of glycerol of beta-lactamase production during high cell density cultivation of recombinant Escherichia_coli .
19956799	0	glycerol	56,64	fps1	51,55	glycerol	fps1	MESH:D005990	850683(Tax:4932)	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Identification of positive regulators of the yeast fps1 glycerol channel .
26267115	0	glycerol	40,48	fps1	62,66	glycerol	fps1	MESH:D005990	850683(Tax:4932)	Chemical	Gene	formation|amod|START_ENTITY formation|nmod|mutants mutants|amod|END_ENTITY	Enhanced ethanol production and reduced glycerol formation in fps1 mutants of Saccharomyces_cerevisiae engineered for improved redox balancing .
11118019	5	glycerol	1281,1289	girls	1321,1326	glycerol	beta2	MESH:D005990	10242	Chemical	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	No significant difference in glycerol release between obese and lean girls or women was detected with selective beta1-stimulation .
3872098	0	glycerol	10,18	glucokinase	22,33	glycerol	glucokinase	MESH:D005990	24385(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effect of glycerol on glucokinase activity : loss of cooperative behavior with respect to glucose .
12679475	0	glycerol	33,41	growth_hormone	10,24	glycerol	growth hormone	MESH:D005990	2688	Chemical	Gene	metabolism|amod|START_ENTITY Effect|nmod|metabolism Effect|nmod|END_ENTITY	Effect of growth_hormone -LRB- GH -RRB- on glycerol and free fatty_acid metabolism during exhaustive exercise in GH-deficient adults .
6833286	0	glycerol	10,18	progesterone_receptor	64,85	glycerol	progesterone receptor	MESH:D005990	25154(Tax:10116)	Chemical	Gene	Action|nmod|START_ENTITY Action|nmod|END_ENTITY	Action of glycerol and sodium_molybdate in stabilization of the progesterone_receptor from rat trophoblast .
12683953	0	glycerol	19,27	pterin_carbinolamine_dehydratase	49,81	glycerol	pterin carbinolamine dehydratase	MESH:D005990	29700(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effects of dietary glycerol on the expression of pterin_carbinolamine_dehydratase in the rat .
16276094	0	glycerol-3-phosphate	72,92	GPAM	115,119	glycerol-3-phosphate	GPAM	MESH:C029620	497202(Tax:9913)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic structure and an alternative transcript of bovine mitochondrial glycerol-3-phosphate acyltransferase gene -LRB- GPAM -RRB- .
22070544	0	glycerol-3-phosphate	46,66	GPAM	84,88	glycerol-3-phosphate	GPAM	MESH:C029620	57678	Chemical	Gene	acyltransferase|amod|START_ENTITY metabolomics|nmod|acyltransferase Integration|nmod|metabolomics Integration|appos|END_ENTITY	Integration of metabolomics and expression of glycerol-3-phosphate acyltransferase -LRB- GPAM -RRB- in breast_cancer-link to patient survival , hormone receptor status , and metabolic profiling .
19033156	0	glycerol-3-phosphate	42,62	Gpdh	95,99	glycerol-3-phosphate	Gpdh	MESH:C029620	33824(Tax:7227)	Chemical	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Direct evidence that genetic variation in glycerol-3-phosphate and malate_dehydrogenase genes -LRB- Gpdh and Mdh1 -RRB- affects adult ethanol tolerance in Drosophila_melanogaster .
21086724	0	glycerol-3-phosphate	46,66	glycerol_kinase	29,44	glycerol-3-phosphate	glycerol kinase	MESH:C029620	2710	Chemical	Gene	oxidase|amod|START_ENTITY oxidase|amod|END_ENTITY	Co-immobilization of lipase , glycerol_kinase , glycerol-3-phosphate oxidase and peroxidase on to aryl_amine glass beads affixed on plastic strip for determination of triglycerides in serum .
17013544	0	glycerol-3-phosphate	30,50	xGPAT1	83,89	glycerol-3-phosphate	xGPAT1	MESH:C029620	215456(Tax:10090)	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Molecular cloning of a murine glycerol-3-phosphate acyltransferase-like protein 1 -LRB- xGPAT1 -RRB- .
11112347	0	glycerol_3-phosphate	49,69	SLC37A1	85,92	glycerol 3-phosphate	SLC37A1	MESH:C029620	54020	Chemical	Gene	gene|amod|START_ENTITY gene|dep|END_ENTITY	Cloning and characterization of a putative human glycerol_3-phosphate permease gene -LRB- SLC37A1 or G3PP -RRB- on 21q22 .3 : mutation analysis in two candidate phenotypes , DFNB10 and a glycerol_kinase deficiency .
21184665	0	glycerol_guaiacolate	31,51	MUC1	12,16	glycerol guaiacolate	MUC1	MESH:D006140	4582	Chemical	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Blockade of MUC1 expression by glycerol_guaiacolate inhibits proliferation of human breast_cancer cells .
6801205	1	glycerol_phosphate	102,120	GPDH	136,140	glycerol phosphate	GPDH	CHEBI:26707	60666(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	The development of cytoplasmic glycerol_phosphate dehydrogenase -LRB- GPDH -RRB- activity in chick neural retina is compared with that in brain .
6808887	0	glycerol_phosphate	20,38	GPDm	54,58	glycerol phosphate	GPDm	CHEBI:26707	2820	Chemical	Gene	dehydrogenase|compound|START_ENTITY dehydrogenase|appos|END_ENTITY	Human mitochondrial glycerol_phosphate dehydrogenase -LRB- GPDm -RRB- isozymes .
19673898	0	glyceryl_trinitrate	53,72	Calcitonin_gene-related_peptide	0,31	glyceryl trinitrate	Calcitonin gene-related peptide	MESH:D005996	796	Chemical	Gene	levels|nmod|START_ENTITY levels|amod|END_ENTITY	Calcitonin_gene-related_peptide -LRB- CGRP -RRB- levels during glyceryl_trinitrate -LRB- GTN -RRB- - induced headache in healthy volunteers .
8100477	0	glyceryl_trinitrate	53,72	glutathione_S-transferase	24,49	glyceryl trinitrate	glutathione S-transferase	MESH:D005996	58962(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY Effect|nmod|activity Effect|nmod|END_ENTITY	Effect of inhibitors of glutathione_S-transferase on glyceryl_trinitrate activity in isolated rat aorta .
15777723	0	glycinamide_ribonucleotide	68,94	GART	114,118	glycinamide ribonucleotide	GART	MESH:C402896	281183(Tax:9913)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular characterization and chromosomal assignment of the bovine glycinamide_ribonucleotide formyltransferase -LRB- GART -RRB- gene on cattle chromosome 1q12.1-q12 .2 .
8358240	0	glycinamide_ribonucleotide	4,30	GART	47,51	glycinamide ribonucleotide	GART	MESH:C402896	2618	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The glycinamide_ribonucleotide transformylase -LRB- GART -RRB- gene is not responsible for familial_amyotrophic_lateral_sclerosis .
18593588	0	glycine	19,26	CA3	61,64	glycine	CA3	CHEBI:57305	54232(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|nmod|END_ENTITY	Zinc modulation of glycine receptors in acutely isolated rat CA3 neurons .
10836608	0	glycine	10,17	COL7A1	69,75	glycine	COL7A1	CHEBI:57305	1294	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	A de novo glycine substitution mutation in the collagenous domain of COL7A1 in dominant dystrophic_epidermolysis_bullosa .
15113589	0	glycine	11,18	COL7A1	44,50	glycine	COL7A1	CHEBI:57305	1294	Chemical	Gene	mutation|amod|START_ENTITY mutation|nmod|END_ENTITY	The G2028R glycine substitution mutation in COL7A1 leads to marked inter-familiar clinical heterogeneity in dominant_dystrophic_epidermolysis_bullosa .
19250433	0	glycine	8,15	COL7A1	32,38	glycine	COL7A1	CHEBI:57305	1294	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	A novel glycine mutation in the COL7A1 gene leading to dominant dystrophic_epidermolysis_bullosa with intra-familial phenotypical heterogeneity .
9347800	0	glycine	6,13	COL7A1	40,46	glycine	COL7A1	CHEBI:57305	1294	Chemical	Gene	mutations|amod|START_ENTITY mutations|nmod|END_ENTITY	Novel glycine substitution mutations in COL7A1 reveal that the Pasini and Cockayne-Touraine variants of dominant dystrophic_epidermolysis_bullosa are allelic .
7319	0	glycine	50,57	D-amino-acid_oxidase	61,81	glycine	D-amino-acid oxidase	CHEBI:57305	1610	Chemical	Gene	Oxidation|nmod|START_ENTITY Oxidation|nmod|END_ENTITY	Oxidation of sarcosine and N-alkyl derivatives of glycine by D-amino-acid_oxidase .
14562417	0	glycine	11,18	ET-1	68,72	glycine	ET-1	D005998	24323(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|contents contents|amod|END_ENTITY	Effects of glycine on plasma and liver tissue changes of TNF-alpha , ET-1 and nitric_oxide contents in rats with obstructive_jaundice .
10798358	0	glycine	6,13	GLDC	34,38	glycine	GLDC	CHEBI:57305	2731	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Human glycine decarboxylase gene -LRB- GLDC -RRB- and its highly conserved processed pseudogene -LRB- psiGLDC -RRB- : their structure and expression , and the identification of a large deletion in a family with nonketotic_hyperglycinemia .
15851735	0	glycine	5,12	GLDC	76,80	glycine	GLDC	CHEBI:57305	2731	Chemical	Gene	encephalopathy|compound|START_ENTITY kindred|nsubj|encephalopathy kindred|nmod|mutation mutation|compound|END_ENTITY	Mild glycine encephalopathy -LRB- NKH -RRB- in a large kindred due to a silent exonic GLDC splice mutation .
15864413	0	glycine	129,136	GLDC	86,90	glycine	GLDC	CHEBI:57305	2731	Chemical	Gene	encephalopathy|amod|START_ENTITY patients|nmod|encephalopathy prevalent|nmod|patients prevalent|nsubj|substitution substitution|acl:relcl|abolishes abolishes|dobj|codon codon|nmod|gene gene|compound|END_ENTITY	A single nucleotide substitution that abolishes the initiator methionine codon of the GLDC gene is prevalent among patients with glycine encephalopathy in Jerusalem .
16601880	0	glycine	69,76	GLDC	29,33	glycine	GLDC	CHEBI:57305	2731	Chemical	Gene	encephalopathy|amod|START_ENTITY patients|nmod|encephalopathy heterogeneity|nmod|patients heterogeneity|nmod|gene gene|compound|END_ENTITY	Genetic heterogeneity of the GLDC gene in 28 unrelated patients with glycine encephalopathy .
23712728	0	glycine	124,131	GLDC	94,98	glycine	GLDC	CHEBI:57305	2731	Chemical	Gene	decarboxylase|compound|START_ENTITY encoding|dobj|decarboxylase findings|acl|encoding findings|nmod|nonketotic_hyperglycinemia nonketotic_hyperglycinemia|amod|due due|nmod|changes changes|nmod|gene gene|compound|END_ENTITY	Characteristic MRI findings in neonatal nonketotic_hyperglycinemia due to sequence changes in GLDC gene encoding the enzyme glycine decarboxylase .
24407464	0	glycine	13,20	GLDC	77,81	glycine	GLDC	CHEBI:57305	2731	Chemical	Gene	encephalopathy|amod|START_ENTITY Diagnosis|nmod|encephalopathy Diagnosis|nmod|mutation mutation|compound|END_ENTITY	Diagnosis of glycine encephalopathy in a pediatric patient by detection of a GLDC mutation during initial next generation DNA sequencing .
11929858	0	glycine	106,113	GLRB	124,128	glycine	GLRB	CHEBI:57305	2743	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Hyperekplexia associated with compound heterozygote mutations in the beta-subunit of the human inhibitory glycine receptor -LRB- GLRB -RRB- .
23238346	0	glycine	32,39	GLRB	65,69	glycine	GLRB	CHEBI:57305	2743	Chemical	Gene	receptor|amod|START_ENTITY mutations|nmod|receptor mutations|appos|END_ENTITY	Novel missense mutations in the glycine receptor b subunit gene -LRB- GLRB -RRB- in startle_disease .
10683205	0	glycine	35,42	GLYT1	78,83	glycine	GLYT1	CHEBI:57305	6536	Chemical	Gene	uptake|amod|START_ENTITY ethanol|nmod|uptake effects|nmod|ethanol mediated|nsubj|effects mediated|nmod|END_ENTITY	Differential effects of ethanol on glycine uptake mediated by the recombinant GLYT1 and GLYT2 glycine transporters .
10694221	0	glycine	66,73	GLYT1	109,114	glycine	GLYT1	CHEBI:57305	6536	Chemical	Gene	uptake|amod|START_ENTITY amoxapine|nmod|uptake effects|nmod|amoxapine mediated|nsubj|effects mediated|nmod|END_ENTITY	Differential effects of the tricyclic antidepressant amoxapine on glycine uptake mediated by the recombinant GLYT1 and GLYT2 glycine transporters .
10722844	0	glycine	49,56	GLYT1	70,75	glycine	GLYT1	CHEBI:57305	116509(Tax:10116)	Chemical	Gene	interactions|nmod|START_ENTITY Characterization|nmod|interactions transporters|nsubj|Characterization transporters|dobj|END_ENTITY	Characterization of the interactions between the glycine transporters GLYT1 and GLYT2 and the SNARE protein syntaxin_1A .
15749988	0	glycine	26,33	GLYT1	20,25	glycine	GLYT1	CHEBI:57305	116509(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Localization Localization|nmod|END_ENTITY	Localization of the GLYT1 glycine transporter at glutamatergic synapses in the rat brain .
17582620	0	glycine	4,11	GLYT1	32,37	glycine	GLYT1	CHEBI:57305	6536	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The glycine transporter 1 gene -LRB- GLYT1 -RRB- is associated with methamphetamine-use disorder .
17597258	0	glycine	44,51	GLYT1	65,70	glycine	GLYT1	CHEBI:57305	14664(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY transporters|nsubj|expression transporters|dobj|END_ENTITY	Functional expression of release-regulating glycine transporters GLYT1 on GABAergic neurons and GLYT2 on astrocytes in mouse spinal cord .
20477934	0	glycine	25,32	GLYT1	19,24	glycine	GLYT1	CHEBI:57305	14664(Tax:10090)	Chemical	Gene	transporters|compound|START_ENTITY transporters|amod|END_ENTITY	Functional ` glial ' GLYT1 glycine transporters expressed in neurons .
7582108	0	glycine	57,64	GLYT1	78,83	glycine	GLYT1	CHEBI:57305	116509(Tax:10116)	Chemical	Gene	distribution|nmod|START_ENTITY transporters|nsubj|distribution transporters|dobj|END_ENTITY	Regional distribution and developmental variation of the glycine transporters GLYT1 and GLYT2 in the rat CNS .
7721869	0	glycine	71,78	GLYT1	65,70	glycine	GLYT1	CHEBI:57305	6536	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	The role of N-glycosylation in the targeting and activity of the GLYT1 glycine transporter .
8667011	0	glycine	32,39	GLYT1	53,58	glycine	GLYT1	CHEBI:57305	14664(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY transporters|nsubj|expression transporters|dobj|END_ENTITY	Developmental expression of the glycine transporters GLYT1 and GLYT2 in mouse brain .
9179600	0	glycine	27,34	GLYT1	47,52	glycine	GLYT1	CHEBI:57305	6536	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Neuronal dependency of the glycine transporter GLYT1 expression in glial cells .
10683205	0	glycine	94,101	GLYT2	88,93	glycine	GLYT2	CHEBI:57305	9152	Chemical	Gene	transporters|compound|START_ENTITY transporters|compound|END_ENTITY	Differential effects of ethanol on glycine uptake mediated by the recombinant GLYT1 and GLYT2 glycine transporters .
10694221	0	glycine	125,132	GLYT2	119,124	glycine	GLYT2	CHEBI:57305	2681	Chemical	Gene	transporters|compound|START_ENTITY transporters|compound|END_ENTITY	Differential effects of the tricyclic antidepressant amoxapine on glycine uptake mediated by the recombinant GLYT1 and GLYT2 glycine transporters .
11278707	0	glycine	61,68	GLYT2	81,86	glycine	GLYT2	CHEBI:57305	9152	Chemical	Gene	transporter|compound|START_ENTITY trafficking|nmod|transporter END_ENTITY|nsubj|trafficking	Calcium - and syntaxin 1-mediated trafficking of the neuronal glycine transporter GLYT2 .
17962467	0	glycine	81,88	GLYT2	72,77	glycine	GLYT2	CHEBI:57305	171148(Tax:10116)	Chemical	Gene	uptake|amod|START_ENTITY reveals|nmod|uptake reveals|dobj|role role|nmod|END_ENTITY	Mapping of glutathione and its precursor amino_acids reveals a role for GLYT2 in glycine uptake in the lens core .
18266927	0	glycine	13,20	GLYT2	33,38	glycine	GLYT2	CHEBI:57305	9152	Chemical	Gene	associates|amod|START_ENTITY associates|compound|END_ENTITY	The neuronal glycine transporter GLYT2 associates with membrane rafts : functional modulation by lipid environment .
19875446	0	glycine	89,96	GLYT2	31,36	glycine	GLYT2	CHEBI:57305	171148(Tax:10116)	Chemical	Gene	transport|amod|START_ENTITY inhibition|nmod|transport required|nmod|inhibition required|csubjpass|Extracellular Extracellular|dobj|loops loops|nmod|END_ENTITY	Extracellular loops 2 and 4 of GLYT2 are required for N-arachidonylglycine inhibition of glycine transport .
7861131	0	glycine	106,113	GLYT2	54,59	glycine	GLYT2	CHEBI:57305	104245(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY distribution|nmod|receptor reveals|nmod|distribution reveals|nsubj|Localization Localization|nmod|transporter transporter|appos|END_ENTITY	Localization of glycine neurotransmitter transporter -LRB- GLYT2 -RRB- reveals correlation with the distribution of glycine receptor .
7861131	0	glycine	16,23	GLYT2	54,59	glycine	GLYT2	CHEBI:57305	104245(Tax:10090)	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Localization of glycine neurotransmitter transporter -LRB- GLYT2 -RRB- reveals correlation with the distribution of glycine receptor .
9472410	0	glycine	83,90	GLYT2	52,57	glycine	GLYT2	CHEBI:57305	171148(Tax:10116)	Chemical	Gene	horn|amod|START_ENTITY study|nmod|horn study|nmod|END_ENTITY	An ultrastructural study of the glycine transporter GLYT2 and its association with glycine in the superficial laminae of the rat spinal dorsal horn .
9509996	0	glycine	51,58	GLYT2	71,76	glycine	GLYT2	CHEBI:57305	171148(Tax:10116)	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Characterization of the 5 ' region of the rat brain glycine transporter GLYT2 gene : identification of a novel isoform .
14715953	0	glycine	25,32	Gephyrin	0,8	glycine	Gephyrin	CHEBI:57305	268566(Tax:10090)	Chemical	Gene	clustering|amod|START_ENTITY critical|nmod|clustering critical|nsubj|END_ENTITY	Gephyrin is critical for glycine receptor clustering but not for the formation of functional GABAergic synapses in hippocampal neurons .
8264797	0	glycine	44,51	Gephyrin	0,8	glycine	Gephyrin	CHEBI:57305	10243	Chemical	Gene	receptor|amod|START_ENTITY prevent|dobj|receptor prevent|nsubj|oligonucleotides oligonucleotides|compound|END_ENTITY	Gephyrin antisense oligonucleotides prevent glycine receptor clustering in spinal neurons .
15331688	0	glycine	30,37	GlyT1	15,20	glycine	GlyT1	CHEBI:57305	14664(Tax:10090)	Chemical	Gene	uptake|amod|START_ENTITY mediates|dobj|uptake mediates|nsubj|END_ENTITY	Bergmann glial GlyT1 mediates glycine uptake and release in mouse cerebellar slices .
17017963	0	glycine	43,50	GlyT1	71,76	glycine	GlyT1	CHEBI:57305	6536	Chemical	Gene	preparation|nmod|START_ENTITY Progress|nmod|preparation transporter|nsubj|Progress transporter|dobj|inhibitors inhibitors|appos|END_ENTITY	Progress in the preparation and testing of glycine transporter type-1 -LRB- GlyT1 -RRB- inhibitors .
18815213	0	glycine	27,34	GlyT1	14,19	glycine	GlyT1	CHEBI:57305	100126661(Tax:8355)	Chemical	Gene	transport|amod|START_ENTITY affect|dobj|transport affect|nsubj|Inhibitors Inhibitors|nmod|END_ENTITY	Inhibitors of GlyT1 affect glycine transport via discrete binding sites .
21348870	0	glycine	13,20	GlyT1	21,26	glycine	GlyT1	CHEBI:57305	116509(Tax:10116)	Chemical	Gene	transporter|amod|START_ENTITY transporter|amod|END_ENTITY	Pre-synaptic glycine GlyT1 transporter -- NMDA receptor interaction : relevance to NMDA autoreceptor activation in the presence of Mg2 + ions .
25301276	0	glycine	168,175	GlyT1	21,26	glycine	GlyT1	CHEBI:57305	100126661(Tax:8355)	Chemical	Gene	terminated|nmod|START_ENTITY 3b|acl:relcl|terminated modulated|nmod|3b modulated|nsubjpass|END_ENTITY	Glycine transporters GlyT1 and GlyT2 are differentially modulated by glycogen synthase kinase 3b Inhibitory glycinergic neurotransmission is terminated by the specific glycine transporters GlyT1 and GlyT2 which actively reuptake glycine from the synaptic cleft .
25301276	0	glycine	229,236	GlyT1	21,26	glycine	GlyT1	CHEBI:57305	100126661(Tax:8355)	Chemical	Gene	reuptake|xcomp|START_ENTITY GlyT1|acl:relcl|reuptake transporters|dobj|GlyT1 transporters|nsubj|transporters transporters|acl:relcl|modulated modulated|nsubjpass|END_ENTITY	Glycine transporters GlyT1 and GlyT2 are differentially modulated by glycogen synthase kinase 3b Inhibitory glycinergic neurotransmission is terminated by the specific glycine transporters GlyT1 and GlyT2 which actively reuptake glycine from the synaptic cleft .
25435080	0	glycine	40,47	GlyT1	86,91	glycine	GlyT1	CHEBI:57305	116509(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|nmod|effects effects|nmod|END_ENTITY	Involvement of the strychnine-sensitive glycine receptor in the anxiolytic effects of GlyT1 inhibitors on maternal separation-induced ultrasonic vocalization in rat pups .
14675166	0	glycine	54,61	GlyT2	75,80	glycine	GlyT2	CHEBI:57305	9152	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Calpain-mediated proteolytic cleavage of the neuronal glycine transporter , GlyT2 .
21420493	0	glycine	75,82	GlyT2	95,100	glycine	GlyT2	CHEBI:57305	9152	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Startle_disease in Irish wolfhounds associated with a microdeletion in the glycine transporter GlyT2 gene .
22978602	0	glycine	28,35	GlyT2	49,54	glycine	GlyT2	CHEBI:57305	2681	Chemical	Gene	transport|amod|START_ENTITY inhibits|dobj|transport inhibits|nmod|END_ENTITY	Oleoyl-L-carnitine inhibits glycine transport by GlyT2 .
23994185	4	glycine	529,536	GlyT2	498,503	glycine	GlyT2	CHEBI:57305	171148(Tax:10116)	Chemical	Gene	uptake|nmod|START_ENTITY regulates|dobj|uptake regulates|nsubj|glycine_transporter_2 glycine_transporter_2|appos|END_ENTITY	The glycine_transporter_2 -LRB- GlyT2 -RRB- regulates the uptake of glycine into presynaptic boutons .
24273061	0	glycine	19,26	GlyT2	27,32	glycine	GlyT2	CHEBI:57305	2681	Chemical	Gene	transporters|amod|START_ENTITY transporters|amod|END_ENTITY	A new function for glycine GlyT2 transporters : Stimulation of y-aminobutyric_acid release from cerebellar nerve terminals through GAT1 transporter reversal and Ca -LRB- 2 + -RRB- - dependent anion channels .
10910114	0	glycine	14,21	Glyt-1	50,56	glycine	Glyt-1	CHEBI:57305	116509(Tax:10116)	Chemical	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression of glycine and the glycine transporter Glyt-1 in the developing rat retina .
1222231	0	glycine	26,33	Growth_hormone	0,14	glycine	Growth hormone	CHEBI:57305	2688	Chemical	Gene	release|nmod|START_ENTITY release|amod|END_ENTITY	Growth_hormone release by glycine injected intravenously in 22 healthy sexually immature children .
1802033	0	glycine	66,73	H-protein	49,58	glycine	H-protein	CHEBI:57305	415803(Tax:9031)	Chemical	Gene	cleavage|amod|START_ENTITY END_ENTITY|nmod|cleavage	An Escherichia_coli protein with homology to the H-protein of the glycine cleavage enzyme complex from pea and chicken liver .
17308032	0	glycine	33,40	Insulin	0,7	glycine	Insulin	CHEBI:57305	3630	Chemical	Gene	potency|nmod|START_ENTITY increases|dobj|potency increases|nsubj|END_ENTITY	Insulin increases the potency of glycine at ionotropic glycine receptors .
17308032	0	glycine	55,62	Insulin	0,7	glycine	Insulin	CHEBI:57305	3630	Chemical	Gene	receptors|compound|START_ENTITY increases|nmod|receptors increases|nsubj|END_ENTITY	Insulin increases the potency of glycine at ionotropic glycine receptors .
12697759	0	glycine	54,61	N-methyl-D-aspartate_receptor	24,53	glycine	N-methyl-D-aspartate receptor	CHEBI:57305	397953(Tax:8355)	Chemical	Gene	site|compound|START_ENTITY site|amod|END_ENTITY	Structural model of the N-methyl-D-aspartate_receptor glycine site probed by site-directed chemical coupling .
8650214	0	glycine	4,11	N-methyl-D-aspartate_receptor_subunit_NR1	32,73	glycine	N-methyl-D-aspartate receptor subunit NR1	CHEBI:57305	2902	Chemical	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	The glycine binding site of the N-methyl-D-aspartate_receptor_subunit_NR1 : identification of novel determinants of co-agonist potentiation in the extracellular M3-M4 loop region .
12586454	0	glycine	102,109	NMDA_R1	94,101	glycine	NMDA R1	CHEBI:57305	14810(Tax:10090)	Chemical	Gene	site|compound|START_ENTITY site|compound|END_ENTITY	Involvement of NMDA receptors in alcohol-mediated behavior : mice with reduced affinity of the NMDA_R1 glycine binding site display an attenuated sensitivity to ethanol .
9685327	0	glycine	53,60	NR1	113,116	glycine	NR1	CHEBI:57305	24408(Tax:10116)	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Expression and initial characterization of a soluble glycine binding domain of the N-methyl-D-aspartate receptor NR1 subunit .
17320117	0	glycine	57,64	NR3A	52,56	glycine	NR3A	CHEBI:57305	116443	Chemical	Gene	START_ENTITY|nsubj|Characterisation Characterisation|nmod|END_ENTITY	Characterisation of the human NMDA receptor subunit NR3A glycine binding site .
12821378	0	glycine	31,38	Protein_kinase_C	0,16	glycine	Protein kinase C	CHEBI:57305	112476	Chemical	Gene	release|amod|START_ENTITY regulation|nmod|release regulation|amod|END_ENTITY	Protein_kinase_C regulation of glycine and gamma-aminobutyric_acid release in brain stem auditory nuclei .
17372332	0	glycine	39,46	SR-BI	54,59	glycine	SR-BI	CHEBI:57305	949	Chemical	Gene	START_ENTITY|nmod|transport transport|amod|END_ENTITY	Effects of amino_acid substitutions at glycine 420 on SR-BI cholesterol transport function .
2932364	0	glycine	17,24	THPO	57,61	glycine	THPO	CHEBI:57305	21832(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|effect effect|nmod|END_ENTITY	Amplification by glycine of the anticonvulsant effect of THPO , a GABA uptake inhibitor .
3216948	0	glycine	17,24	THPO	71,75	glycine	THPO	CHEBI:57305	21832(Tax:10090)	Chemical	Gene	Amplification|nmod|START_ENTITY inhibitor|nsubj|Amplification inhibitor|dobj|END_ENTITY	Amplification by glycine of the effect of the GABA transport inhibitor THPO on synaptosomal GABA level .
14562417	0	glycine	11,18	TNF-alpha	57,66	glycine	TNF-alpha	D005998	24835(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|contents contents|amod|END_ENTITY	Effects of glycine on plasma and liver tissue changes of TNF-alpha , ET-1 and nitric_oxide contents in rats with obstructive_jaundice .
9419055	0	glycine	32,39	acetylcholinesterase	62,82	glycine	acetylcholinesterase	CHEBI:57305	11423(Tax:10090)	Chemical	Gene	release|amod|START_ENTITY release|amod|END_ENTITY	In vivo and in vitro studies of glycine - and glutamate-evoked acetylcholinesterase release from spinal motor neurones : implications for amyotrophic_lateral_sclerosis / motor neurone disease pathogenesis .
15147510	0	glycine	54,61	alpha1	36,42	glycine	alpha1	CHEBI:57305	146	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Multiple sites of ethanol action in alpha1 and alpha2 glycine receptors suggested by sensitivity to pressure antagonism .
19626554	0	glycine	99,106	alpha1_and_alpha3	81,98	glycine	alpha1 and alpha3	CHEBI:57305	146	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	The M4 transmembrane segment contributes to agonist efficacy differences between alpha1_and_alpha3 glycine receptors .
10998097	0	glycine	84,91	alpha2	92,98	glycine	alpha2	CHEBI:57305	779129(Tax:8355)	Chemical	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Evidence for coassembly of mutant GABAC rho1 with GABAA gamma2S , glycine alpha1 and glycine alpha2 receptor subunits in vitro .
11772442	0	glycine	113,120	alpha_1	105,112	glycine	alpha 1	CHEBI:57305	146	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Achieving optimal expression for single channel recording : a plasmid ratio approach to the expression of alpha_1 glycine receptors in HEK293 cells .
12619677	0	glycine	34,41	aminopeptidase	6,20	glycine	aminopeptidase	CHEBI:57305	10404	Chemical	Gene	specific|nmod|START_ENTITY END_ENTITY|xcomp|specific	Novel aminopeptidase specific for glycine from Actinomucor elegans .
8309846	0	glycine	98,105	atrial_natriuretic_peptide	7,33	glycine	atrial natriuretic peptide	CHEBI:57305	100294648(Tax:9940)	Chemical	Gene	solution|compound|START_ENTITY END_ENTITY|nmod|solution	Plasma atrial_natriuretic_peptide concentration and renin activity during overhydration with 1.5 % glycine solution in conscious sheep .
17336757	0	glycine	12,19	beta2-adrenoceptor	20,38	glycine	beta2-adrenoceptor	CHEBI:57305	154	Chemical	Gene	polymorphism|amod|START_ENTITY polymorphism|amod|END_ENTITY	Arginine 16 glycine beta2-adrenoceptor polymorphism and cardiovascular structure and function in patients with heart_failure .
2827069	0	glycine	62,69	choline_acetyltransferase	19,44	glycine	choline acetyltransferase	CHEBI:57305	290567(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Co-localization of choline_acetyltransferase and postsynaptic glycine receptors in motoneurons of rat spinal cord demonstrated by immunocytochemistry .
10037506	0	glycine	48,55	gephyrin	81,89	glycine	gephyrin	CHEBI:57305	10243	Chemical	Gene	beta-subunit|amod|START_ENTITY beta-subunit|nmod|END_ENTITY	Hydrophobic interactions mediate binding of the glycine receptor beta-subunit to gephyrin .
11056469	0	glycine	40,47	gephyrin	79,87	glycine	gephyrin	CHEBI:57305	268566(Tax:10090)	Chemical	Gene	receptors|amod|START_ENTITY receptors|nmod|retina retina|nmod|END_ENTITY	Reduced synaptic clustering of GABA and glycine receptors in the retina of the gephyrin null mutant mouse .
1318846	0	glycine	106,113	gephyrin	48,56	glycine	gephyrin	CHEBI:57305	10243	Chemical	Gene	receptors|compound|START_ENTITY affinities|nmod|receptors changes|dobj|affinities changes|nsubj|Coexpression Coexpression|nmod|END_ENTITY	Coexpression of the receptor-associated protein gephyrin changes the ligand binding affinities of alpha 2 glycine receptors .
1319186	0	glycine	74,81	gephyrin	53,61	glycine	gephyrin	CHEBI:57305	10243	Chemical	Gene	START_ENTITY|nsubj|structure structure|nmod|END_ENTITY	Primary structure and alternative splice variants of gephyrin , a putative glycine receptor-tubulin linker protein .
15201864	0	glycine	28,35	gephyrin	59,67	glycine	gephyrin	CHEBI:57305	10243	Chemical	Gene	receptor|compound|START_ENTITY basis|nmod|receptor basis|acl|clustering clustering|nmod|END_ENTITY	Structural basis of dynamic glycine receptor clustering by gephyrin .
16511563	0	glycine	40,47	gephyrin	70,78	glycine	gephyrin	CHEBI:57305	10243	Chemical	Gene	receptor|amod|START_ENTITY receptor|acl|anchoring anchoring|nmod|END_ENTITY	Deciphering the structural framework of glycine receptor anchoring by gephyrin .
17347650	0	glycine	89,96	gephyrin	45,53	glycine	gephyrin	CHEBI:57305	268566(Tax:10090)	Chemical	Gene	function|amod|START_ENTITY modulate|dobj|function mechanism|acl|modulate represents|dobj|mechanism represents|nsubj|isomerisation isomerisation|nmod|END_ENTITY	Post-phosphorylation prolyl isomerisation of gephyrin represents a mechanism to modulate glycine receptors function .
25531214	0	glycine	63,70	gephyrin	89,97	glycine	gephyrin	CHEBI:57305	10243	Chemical	Gene	receptors|amod|START_ENTITY basis|nmod|receptors basis|nmod|END_ENTITY	Molecular basis of the alternative recruitment of GABAA versus glycine receptors through gephyrin .
8242343	0	glycine	46,53	gephyrin	25,33	glycine	gephyrin	CHEBI:57305	64845(Tax:10116)	Chemical	Gene	protein|amod|START_ENTITY END_ENTITY|appos|protein	Widespread expression of gephyrin , a putative glycine receptor-tubulin linker protein , in rat brain .
9812897	0	glycine	33,40	gephyrin	21,29	glycine	gephyrin	CHEBI:57305	10243	Chemical	Gene	clustering|amod|START_ENTITY requirement|nmod|clustering requirement|nmod|END_ENTITY	Dual requirement for gephyrin in glycine receptor clustering and molybdoenzyme activity .
11456285	0	glycine	10,17	insulin	21,28	glycine	insulin	CHEBI:57305	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of glycine on insulin secretion and action in healthy first-degree relatives of type_2_diabetes_mellitus patients .
5660637	1	glycine	81,88	insulin	70,77	glycine	insulin	CHEBI:57305	396145(Tax:9031)	Chemical	Gene	accumulation|amod|START_ENTITY effect|nmod|accumulation effect|nmod|END_ENTITY	The effect of insulin on glycine and leucine accumulation .
12527000	0	glycine	28,35	leptin_receptor	54,69	glycine	leptin receptor	CHEBI:57305	3953	Chemical	Gene	receptor|amod|START_ENTITY receptor|nmod|END_ENTITY	In vitro interaction of the glycine receptor with the leptin_receptor .
9027383	0	glycine	4,11	neurokinin1_receptor	53,73	glycine	neurokinin1 receptor	CHEBI:57305	24807(Tax:10116)	Chemical	Gene	site|amod|START_ENTITY contributes|nsubj|site contributes|nmod|facilitation facilitation|amod|END_ENTITY	The glycine site of the NMDA receptor contributes to neurokinin1_receptor agonist facilitation of NMDA receptor agonist-evoked activity in rat dorsal horn neurons .
6627039	0	glycine	23,30	prolactin	49,58	glycine	prolactin	CHEBI:57305	24683(Tax:10116)	Chemical	Gene	actions|nmod|START_ENTITY actions|nmod|secretion secretion|compound|END_ENTITY	The central actions of glycine and strychnine on prolactin and LH secretion .
2983837	0	glycine	4,11	spastic	41,48	glycine	spastic	CHEBI:57305	14658(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|nmod|END_ENTITY	The glycine receptor in the mutant mouse spastic -LRB- spa -RRB- : strychnine binding characteristics and pharmacology .
11027169	0	glycine_betaine	25,40	thrombopoietin	44,58	glycine betaine	thrombopoietin	MESH:D001622	100774906	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Osmoprotective effect of glycine_betaine on thrombopoietin production in hyperosmotic Chinese_hamster ovary cell culture : clonal variations .
15277574	0	glycine_hydrazide	13,30	CFTR	46,50	glycine hydrazide	CFTR	null	12638(Tax:10090)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Discovery of glycine_hydrazide pore-occluding CFTR inhibitors : mechanism , structure-activity analysis , and in vivo efficacy .
24276222	0	glycinin	57,65	A1-5	40,44	glycinin	A1-5	null	363447(Tax:10116)	Chemical	Gene	subunits|nmod|START_ENTITY subunits|compound|END_ENTITY	The a ' subunit of b-conglycinin and the A1-5 subunits of glycinin are not essential for many hypolipidemic actions of dietary soy proteins in rats .
8698134	0	glycocalicin	32,44	thrombopoietin	6,20	glycocalicin	thrombopoietin	null	7066	Chemical	Gene	concentrations|compound|START_ENTITY concentrations|compound|END_ENTITY	Serum thrombopoietin and plasma glycocalicin concentrations as useful diagnostic markers in thrombocytopenic_disorders .
10350620	0	glycodelin_A	137,149	glycodelin_A	31,43	glycodelin A	glycodelin A	null	5047	Chemical	Gene	comparison|nmod|START_ENTITY properties|dep|comparison properties|nmod|END_ENTITY	Structural properties of human glycodelin_A in water and in water-alcohol mixtures : a comparison with bovine beta-lactoglobulin A. Human glycodelin_A -LRB- GdA -RRB- is a glycoprotein that is highly homologous to bovine beta-lactoglobulin A -LRB- beta-LgA -RRB- because the amino_acid sequences are 50-60 % identical .
12213282	0	glycolic_acid	21,34	c-fos	60,65	glycolic acid	c-fos	MESH:C031149	2353	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Inhibitory effect of glycolic_acid on ultraviolet B-induced c-fos expression , AP-1 activation and p53-p21 response in a human keratinocyte cell line .
17143546	0	glycolipid	37,47	p53	114,117	glycolipid	p53	CHEBI:33563	7157	Chemical	Gene	relationship|nmod|START_ENTITY relationship|nmod|END_ENTITY	Structure-activity relationship of a glycolipid , sulfoquinovosyl_diacylglycerol , with the DNA binding activity of p53 .
10455156	0	glycosulfopeptide	8,25	P-selectin	35,45	glycosulfopeptide	P-selectin	null	6403	Chemical	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	A novel glycosulfopeptide binds to P-selectin and inhibits leukocyte adhesion to P-selectin .
23712085	0	glycosyl	37,45	luteinizing_hormone-releasing_hormone	61,98	glycosyl	luteinizing hormone-releasing hormone	null	2796	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Synthesis and in vitro evaluation of glycosyl derivatives of luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- .
2476803	0	glycosyl-inositolphospholipid	23,52	Thy-1_antigen	80,93	glycosyl-inositolphospholipid	Thy-1 antigen	null	21838(Tax:10090)	Chemical	Gene	structures|amod|START_ENTITY structures|nmod|END_ENTITY	In vitro attachment of glycosyl-inositolphospholipid anchor structures to mouse Thy-1_antigen and human decay-accelerating_factor .
16642471	0	glycosyl-phosphatidylinositol	24,53	GPAA1	83,88	glycosyl-phosphatidylinositol	GPAA1	MESH:D017261	8733	Chemical	Gene	protein|amod|START_ENTITY expression|nmod|protein expression|appos|END_ENTITY	Increased expression of glycosyl-phosphatidylinositol anchor attachment protein 1 -LRB- GPAA1 -RRB- is associated with gene amplification in hepatocellular_carcinoma .
12777063	0	glycosylphosphatidyl-inositol	52,81	GPI-80	16,22	glycosylphosphatidyl-inositol	GPI-80	MESH:D017261	8875	Chemical	Gene	protein|amod|START_ENTITY END_ENTITY|appos|protein	Localization of GPI-80 , a beta2-integrin-associated glycosylphosphatidyl-inositol anchored protein , on strongly CD14-positive human monocytes .
14660601	0	glycosylphosphatidylinositol	78,106	GPI_transamidase	128,144	glycosylphosphatidylinositol	GPI transamidase	MESH:D017261	606750(Tax:9823)	Chemical	Gene	recognition|amod|START_ENTITY recognition|nmod|END_ENTITY	A conserved proline in the last transmembrane segment of Gaa1 is required for glycosylphosphatidylinositol -LRB- GPI -RRB- recognition by GPI_transamidase .
8407896	0	glycosylphosphatidylinositol	36,64	Ltk	88,91	glycosylphosphatidylinositol	Ltk	MESH:D017261	17005(Tax:10090)	Chemical	Gene	biosynthesis|amod|START_ENTITY biosynthesis|nmod|END_ENTITY	Correction of the class H defect in glycosylphosphatidylinositol anchor biosynthesis in Ltk - cells by a human cDNA clone .
12082541	0	glycosylphosphatidylinositol	32,60	MAM	61,64	glycosylphosphatidylinositol	MAM	MESH:D017261	6445	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Genomic organization of a novel glycosylphosphatidylinositol MAM gene expressed in human tissues and tumors .
18544084	0	glycosylphosphatidylinositol	79,107	PIG-A	125,130	glycosylphosphatidylinositol	PIG-A	MESH:D017261	100156880(Tax:9823)	Chemical	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	Altered lipid raft composition and defective cell death signal transduction in glycosylphosphatidylinositol anchor-deficient PIG-A mutant cells .
20427543	0	glycosylphosphatidylinositol	25,53	PrP	80,83	glycosylphosphatidylinositol	PrP	MESH:D017261	100008658(Tax:9986)	Chemical	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Residues surrounding the glycosylphosphatidylinositol anchor attachment site of PrP modulate prion infection : insight from the resistance of rabbits to prion_disease .
15557253	0	glycosylphosphatidylinositols	8,37	phospholipase_A2	59,75	glycosylphosphatidylinositols	phospholipase A2	MESH:D017261	151056	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Role of glycosylphosphatidylinositols in the activation of phospholipase_A2 and the neurotoxicity of prions .
1933514	0	glycyl-L-glutamine	124,142	acetylcholinesterase	16,36	glycyl-L-glutamine	acetylcholinesterase	MESH:C039788	11423(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY Regeneration|dep|effect Regeneration|nmod|END_ENTITY	Regeneration of acetylcholinesterase in clonal_neuroblastoma-glioma hybrid NG108-15 cells after soman inhibition : effect of glycyl-L-glutamine .
2251290	0	glycyl-L-glutamine	11,29	acetylcholinesterase	71,91	glycyl-L-glutamine	acetylcholinesterase	MESH:C039788	83817(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of glycyl-L-glutamine and methylprednisolone on maintenance of acetylcholinesterase of transected rat sciatic nerves .
2726774	0	glycyl-L-glutamine	10,28	acetylcholinesterase	60,80	glycyl-L-glutamine	acetylcholinesterase	MESH:C039788	83817(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|rate rate|nmod|regeneration regeneration|nmod|END_ENTITY	Effect of glycyl-L-glutamine on the rate of regeneration of acetylcholinesterase in the rat gastrocnemius muscle after diisopropyl_phosphorofluoridate administration .
8198538	0	glycyl-L-phenylalanine_2-naphthylamide	7,45	cathepsin_C	69,80	glycyl-L-phenylalanine 2-naphthylamide	cathepsin C	MESH:C041865	25423(Tax:10116)	Chemical	Gene	START_ENTITY|appos|substrate substrate|amod|END_ENTITY	Use of glycyl-L-phenylalanine_2-naphthylamide , a lysosome-disrupting cathepsin_C substrate , to distinguish between lysosomes and prelysosomal endocytic vacuoles .
6954514	0	glycyl-L-prolyl-L-arginyl-L-proline	72,107	fibrinogen	14,24	glycyl-L-prolyl-L-arginyl-L-proline	fibrinogen	null	2244	Chemical	Gene	binding|nmod|START_ENTITY binding|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of fibrinogen binding to human platelets by the tetrapeptide glycyl-L-prolyl-L-arginyl-L-proline .
11408272	0	glycylsarcosine	33,48	Epidermal_growth_factor	0,23	glycylsarcosine	Epidermal growth factor	MESH:C004194	1950	Chemical	Gene	transport|amod|START_ENTITY inhibits|dobj|transport inhibits|nsubj|END_ENTITY	Epidermal_growth_factor inhibits glycylsarcosine transport and hPepT1 expression in a human intestinal cell line .
15497696	0	glycylsarcosine	46,61	PEPT2	8,13	glycylsarcosine	PEPT2	MESH:C004194	57738(Tax:10090)	Chemical	Gene	uptake|nmod|START_ENTITY END_ENTITY|nmod|uptake	Role of PEPT2 in the choroid plexus uptake of glycylsarcosine and 5-aminolevulinic_acid : studies in wild-type and null mice .
15987832	0	glycylsarcosine	107,122	peptide_transporter_2	22,43	glycylsarcosine	peptide transporter 2	MESH:C004194	57738(Tax:10090)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role and relevance of peptide_transporter_2 -LRB- PEPT2 -RRB- in the kidney and choroid plexus : in vivo studies with glycylsarcosine in wild-type and PEPT2 knockout mice .
10620097	0	glycyrrhetinic_acid	59,78	aid	83,86	glycyrrhetinic acid	aid	MESH:D006034	57379	Chemical	Gene	analysis|nmod|START_ENTITY analysis|dep|END_ENTITY	Gas chromatographic-mass spectrometric analysis of urinary glycyrrhetinic_acid : an aid in diagnosing liquorice abuse .
26900660	0	glycyrrhetinic_acid	64,83	carboxylesterase_2	145,163	glycyrrhetinic acid	carboxylesterase 2	MESH:D006034	8824	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|inhibitors inhibitors|nmod|END_ENTITY	Design , synthesis , and structure-activity relationship study of glycyrrhetinic_acid derivatives as potent and selective inhibitors against human carboxylesterase_2 .
21042038	0	glycyrrhetinic_acid	43,62	cytochrome_P450_3A	66,84	glycyrrhetinic acid	cytochrome P450 3A	MESH:D006034	1576	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	In vitro and in vivo inhibitory effects of glycyrrhetinic_acid on cytochrome_P450_3A activity .
17511148	0	glycyrrhiizin	23,36	TNF-alpha	55,64	glycyrrhiizin	TNF-alpha	null	24835(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of combination glycyrrhiizin and triptolide on TNF-alpha and IL-10 in serum of collagen induced arthritis rats -RSB- .
10879279	0	glycyrrhizic_acid	11,28	corticotropin_releasing_factor	54,84	glycyrrhizic acid	corticotropin releasing factor	MESH:D019695	81648(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|END_ENTITY	Effects of glycyrrhizic_acid and steroid treatment on corticotropin_releasing_factor and beta-endorphin containing neurons of the hypothalamus of the rat .
10366987	0	glycyrrhizin	22,34	CCl4	69,73	glycyrrhizin	CCl4	MESH:D019695	116637(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	-LSB- Inhibitory effect of glycyrrhizin on NF-kappa B binding activity in CCl4 plus ethanol induced liver_cirrhosis in rats -RSB- .
9716228	0	glycyrrhizin	21,33	CCl4	67,71	glycyrrhizin	CCl4	MESH:D019695	116637(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	Inhibitory effect of glycyrrhizin on NF-kappaB binding activity in CCl4 - plus ethanol-induced liver_cirrhosis in rats .
20350051	0	glycyrrhizin	10,22	CYP2C19	26,33	glycyrrhizin	CYP2C19	MESH:D019695	1557	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|compound|END_ENTITY	Effect of glycyrrhizin on CYP2C19 and CYP3A4 activity in healthy volunteers with different CYP2C19 genotypes .
20393696	0	glycyrrhizin	10,22	CYP3A	42,47	glycyrrhizin	CYP3A	MESH:D019695	1576	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	Effect of glycyrrhizin on the activity of CYP3A enzyme in humans .
24594628	0	glycyrrhizin	21,33	HMGB1	44,49	glycyrrhizin	HMGB1	MESH:D019695	25459(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Protective effect of glycyrrhizin , a direct HMGB1 inhibitor , on focal cerebral_ischemia / reperfusion-induced inflammation , oxidative stress , and apoptosis in rats .
11213474	0	glycyrrhizin	92,104	Thioredoxin	0,11	glycyrrhizin	Thioredoxin	MESH:D019695	7295	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|levels levels|compound|END_ENTITY	Thioredoxin levels in the sera of untreated viral_hepatitis patients and those treated with glycyrrhizin or ursodeoxycholic_acid .
11991252	0	glycyrrhizin	59,71	activator_protein_1	27,46	glycyrrhizin	activator protein 1	MESH:D019695	16476(Tax:10090)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|activity activity|amod|END_ENTITY	Differential regulation of activator_protein_1 activity by glycyrrhizin .
11510483	0	glycyrrhizin	21,33	high_mobility_group_proteins_1_and_2	86,122	glycyrrhizin	high mobility group proteins 1 and 2	MESH:D019695	3148	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Inhibitory effect of glycyrrhizin on the phosphorylation and DNA-binding abilities of high_mobility_group_proteins_1_and_2 in vitro .
6689106	0	glycyrrhizin	59,71	phospholipase_A2	14,30	glycyrrhizin	phospholipase A2	MESH:D019695	151056	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of phospholipase_A2 and platelet_aggregation by glycyrrhizin , an antiinflammation drug .
9657040	0	glycyrrhizin	54,66	phospholipase_A2	14,30	glycyrrhizin	phospholipase A2	MESH:D019695	151056	Chemical	Gene	venom|nmod|START_ENTITY END_ENTITY|nmod|venom	Separation of phospholipase_A2 in Habu snake venom by glycyrrhizin -LRB- GL -RRB- - affinity column chromatography and identification of a GL-sensitive enzyme .
23964664	0	glycyrrhizin	46,58	thrombin	14,22	glycyrrhizin	thrombin	MESH:D019695	2147	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Improving the thrombin inhibitory activity of glycyrrhizin , a triterpenic_saponin , through a molecular simplification of the carbohydrate moiety .
9196073	0	glycyrrhizin	18,30	thrombin	36,44	glycyrrhizin	thrombin	MESH:D019695	2147	Chemical	Gene	Identification|nmod|START_ENTITY Identification|nmod|inhibitor inhibitor|compound|END_ENTITY	Identification of glycyrrhizin as a thrombin inhibitor .
25603772	0	glyphosate	42,52	GCN2	15,19	glyphosate	GCN2	CHEBI:27744	825110(Tax:3702)	Chemical	Gene	mediates|xcomp|START_ENTITY mediates|nsubj|END_ENTITY	Protein kinase GCN2 mediates responses to glyphosate in Arabidopsis .
24780534	0	glyphosate	14,24	acetylcholinesterase	72,92	glyphosate	acetylcholinesterase	CHEBI:27744	43	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|metabolites metabolites|nmod|activity activity|compound|END_ENTITY	The effect of glyphosate , its metabolites and impurities on erythrocyte acetylcholinesterase activity .
16174533	0	glyphosate_herbicide	10,30	acetylcholinesterase	34,54	glyphosate herbicide	acetylcholinesterase	null	43	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	Effect of glyphosate_herbicide on acetylcholinesterase activity and metabolic and hematological parameters in piava -LRB- Leporinus obtusidens -RRB- .
21597789	0	gn-rh	32,37	Gonadotropin-releasing-hormone	0,30	gn-rh	Gonadotropin-releasing-hormone	MESH:D007987	2796	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Gonadotropin-releasing-hormone -LRB- gn-rh -RRB- _ receptor in the reproductive-tract tumor - physiological-role and signal-transduction pathway .
17009630	0	gnRH	90,94	leptin	11,17	gnRH	leptin	MESH:D007987	3952	Chemical	Gene	women|amod|START_ENTITY Studies|nmod|women Studies|nmod|expression expression|compound|END_ENTITY	Studies on leptin and leptin_receptor gene expression in myometrium and uterine myomas of gnRH analogue-treated women .
22687546	0	gnetin_C	21,29	tyrosinase	84,94	gnetin C	tyrosinase	MESH:C575740	22173(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|amod|END_ENTITY	Inhibitory effect of gnetin_C , a resveratrol dimer from melinjo -LRB- Gnetum gnemon -RRB- , on tyrosinase activity and melanin biosynthesis .
11745413	0	gnidimacrin	38,49	cdk2	58,62	gnidimacrin	cdk2	MESH:C013006	1017	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|amod|END_ENTITY	Antitumor action of the PKC activator gnidimacrin through cdk2 inhibition .
8593832	0	gonadotrophin-releasing_hormone	14,45	GnRH	47,51	gonadotrophin-releasing hormone	GnRH	null	25194(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY secretion|appos|END_ENTITY	Regulation of gonadotrophin-releasing_hormone -LRB- GnRH -RRB- secretion by heme molecules : a regulatory role for carbon_monoxide ?
9136118	0	gonadotrophin-releasing_hormone	21,52	GnRH	54,58	gonadotrophin-releasing hormone	GnRH	null	25194(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Inhibitory effect of gonadotrophin-releasing_hormone -LRB- GnRH -RRB- on rat granulosa cell deoxyribonucleic acid synthesis .
23027641	0	gonadotropin-inhibitory_hormone	55,86	GnRH	48,52	gonadotropin-inhibitory hormone	GnRH	null	14714(Tax:10090)	Chemical	Gene	gonadotropin-releasing_hormone|appos|START_ENTITY gonadotropin-releasing_hormone|appos|END_ENTITY	Localization of gonadotropin-releasing_hormone -LRB- GnRH -RRB- , gonadotropin-inhibitory_hormone -LRB- GnIH -RRB- , kisspeptin and GnRH_receptor and their possible roles in testicular activities from birth to senescence in mice .
25905297	0	gonadotropin-releasing_hormone	73,103	GNRH	0,4	gonadotropin-releasing hormone	GNRH	MESH:D007987	2796	Chemical	Gene	Physiology|advmod|START_ENTITY Physiology|compound|END_ENTITY	GNRH Gonadotropin Physiology and Pathology The hypothalamic decapeptide , gonadotropin-releasing_hormone -LRB- GnRH -RRB- is synthesized and released by the hypothalamus into the hypophyseal-portal circulation .
15240592	0	gonadotropin-releasing_hormone	171,201	GNRHR	0,5	gonadotropin-releasing hormone	GNRHR	MESH:D007987	2798	Chemical	Gene	luteinizing|nmod|START_ENTITY sensitivity|acl|luteinizing highlight|dobj|sensitivity highlight|nsubj|mutations mutations|amod|END_ENTITY	GNRHR mutations in a woman with idiopathic_hypogonadotropic_hypogonadism highlight the differential sensitivity of luteinizing hormone and follicle-stimulating hormone to gonadotropin-releasing_hormone .
23295295	0	gonadotropin-releasing_hormone	22,52	GNRHR	63,68	gonadotropin-releasing hormone	GNRHR	MESH:D007987	2798	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Novel mutation in the gonadotropin-releasing_hormone receptor -LRB- GNRHR -RRB- gene in a patient with normosmic isolated hypogonadotropic_hypogonadism .
24558046	2	gonadotropin-releasing_hormone	327,357	GR	400,402	gonadotropin-releasing hormone	GR	MESH:D007987	2908	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	We have previously shown that gonadotropin-releasing_hormone -LRB- GnRH -RRB- ligand-independently activates the GR and synergistically modulates glucocorticoid-induced transcription of an endogenous gene in LbT2 pituitary gonadotrope precursor cells .
11014215	0	gonadotropin-releasing_hormone	41,71	GnRH	96,100	gonadotropin-releasing hormone	GnRH	MESH:D007987	2796	Chemical	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Transcriptional down-regulation of human gonadotropin-releasing_hormone -LRB- GnRH -RRB- receptor gene by GnRH : role of protein_kinase_C and activating protein 1 .
11923000	0	gonadotropin-releasing_hormone	34,64	GnRH	66,70	gonadotropin-releasing hormone	GnRH	MESH:D007987	2796	Chemical	Gene	START_ENTITY|dobj|systems systems|appos|END_ENTITY	Evolutionary development of three gonadotropin-releasing_hormone -LRB- GnRH -RRB- systems in vertebrates .
12791688	0	gonadotropin-releasing_hormone	33,63	GnRH	134,138	gonadotropin-releasing hormone	GnRH	MESH:D007987	14714(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY localization|nmod|receptor necessary|nsubj|localization necessary|nmod|END_ENTITY	Constitutive localization of the gonadotropin-releasing_hormone _ -LRB- GnRH -RRB- _ receptor to low density membrane microdomains is necessary for GnRH signaling to ERK .
1280208	0	gonadotropin-releasing_hormone	35,65	GnRH	109,113	gonadotropin-releasing hormone	GnRH	MESH:D007987	2796	Chemical	Gene	lines|amod|START_ENTITY lines|dep|stimulation stimulation|nmod|END_ENTITY	Dopaminergic regulation of the GT1 gonadotropin-releasing_hormone -LRB- GnRH -RRB- neuronal cell lines : stimulation of GnRH release via D1-receptors positively coupled to adenylate cyclase .
1280208	0	gonadotropin-releasing_hormone	35,65	GnRH	67,71	gonadotropin-releasing hormone	GnRH	MESH:D007987	2796	Chemical	Gene	lines|amod|START_ENTITY lines|appos|END_ENTITY	Dopaminergic regulation of the GT1 gonadotropin-releasing_hormone -LRB- GnRH -RRB- neuronal cell lines : stimulation of GnRH release via D1-receptors positively coupled to adenylate cyclase .
1354602	0	gonadotropin-releasing_hormone	40,70	GnRH	114,118	gonadotropin-releasing hormone	GnRH	MESH:D007987	2796	Chemical	Gene	lines|amod|START_ENTITY lines|dep|stimulation stimulation|nmod|release release|compound|END_ENTITY	Beta_1-adrenergic regulation of the GT1 gonadotropin-releasing_hormone -LRB- GnRH -RRB- neuronal cell lines : stimulation of GnRH release via receptors positively coupled to adenylate cyclase .
1354602	0	gonadotropin-releasing_hormone	40,70	GnRH	72,76	gonadotropin-releasing hormone	GnRH	MESH:D007987	2796	Chemical	Gene	lines|amod|START_ENTITY lines|appos|END_ENTITY	Beta_1-adrenergic regulation of the GT1 gonadotropin-releasing_hormone -LRB- GnRH -RRB- neuronal cell lines : stimulation of GnRH release via receptors positively coupled to adenylate cyclase .
14565958	0	gonadotropin-releasing_hormone	27,57	GnRH	130,134	gonadotropin-releasing hormone	GnRH	MESH:D007987	2796	Chemical	Gene	_|amod|START_ENTITY Expression|nmod|_ _|nsubj|Expression _|parataxis|underlies underlies|nsubj|loop loop|compound|END_ENTITY	Expression and function of gonadotropin-releasing_hormone _ -LRB- GnRH -RRB- _ receptor in human olfactory GnRH-secreting neurons : an autocrine GnRH loop underlies neuronal migration .
1711159	1	gonadotropin-releasing_hormone	182,212	GnRH	214,218	gonadotropin-releasing hormone	POMC	MESH:D007987	24664(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY secretion|appos|END_ENTITY	The decline in reproductive function with aging is due in part to decreased gonadotropin-releasing_hormone -LRB- GnRH -RRB- secretion .
19858197	0	gonadotropin-releasing_hormone	24,54	GnRH	126,130	gonadotropin-releasing hormone	GnRH	MESH:D007987	2796	Chemical	Gene	signaling|amod|START_ENTITY signaling|parataxis|NFAT NFAT|xcomp|signaling signaling|dobj|frequency frequency|compound|END_ENTITY	Pulsatile and sustained gonadotropin-releasing_hormone _ -LRB- GnRH -RRB- _ receptor signaling : does the Ca2 + / NFAT signaling pathway decode GnRH pulse frequency ?
20301509	0	gonadotropin-releasing_hormone	92,122	GnRH	41,45	gonadotropin-releasing hormone	GnRH	MESH:D007987	2796	Chemical	Gene	deficiency|amod|START_ENTITY characterized|nsubjpass|deficiency Isolated|ccomp|characterized Isolated|nsubj|Gonadotropin-Releasing_Hormone Gonadotropin-Releasing_Hormone|appos|END_ENTITY	Isolated Gonadotropin-Releasing_Hormone -LRB- GnRH -RRB- Deficiency DISEASE CHARACTERISTICS : Isolated gonadotropin-releasing_hormone -LRB- GnRH -RRB- deficiency -LRB- IGD -RRB- is characterized by inappropriately low serum concentrations of the gonadotropins LH -LRB- luteinizing hormone -RRB- and FSH -LRB- follicle-stimulating hormone -RRB- in the setting of hypogonadism .
20507982	0	gonadotropin-releasing_hormone	24,54	GnRH	120,124	gonadotropin-releasing hormone	GnRH	MESH:D007987	2796	Chemical	Gene	signaling|amod|START_ENTITY signaling|parataxis|decode decode|dobj|frequency frequency|amod|END_ENTITY	Pulsatile and sustained gonadotropin-releasing_hormone _ -LRB- GnRH -RRB- _ receptor signaling : does the ERK signaling pathway decode GnRH pulse frequency ?
2160386	1	gonadotropin-releasing_hormone	166,196	GnRH	198,202	gonadotropin-releasing hormone	GnRH	MESH:D007987	25194(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	The regulation of rat gonadotropin-releasing_hormone -LRB- GnRH -RRB- receptors in male rat pituitary , hippocampus and testis was studied , in vivo , under steady-state conditions during treatment with D-Trp6_GnRH -LRB- triptorelin , slow-release form , at 300 micrograms/kg/month -RRB- .
22907516	2	gonadotropin-releasing_hormone	433,463	GnRH	465,469	gonadotropin-releasing hormone	GnRH	MESH:D007987	2796	Chemical	Gene	START_ENTITY|dobj|test test|appos|END_ENTITY	The aim of the study was to evaluate the impact of body mass index -LRB- BMI -RRB- on luteinizing hormone -LRB- LH -RRB- secretion to gonadotropin-releasing_hormone -LRB- GnRH -RRB- stimulation test in boys with precocious puberty .
24202465	0	gonadotropin-releasing_hormone	95,125	GnRH	127,131	gonadotropin-releasing hormone	GnRH	MESH:D007987	14714(Tax:10090)	Chemical	Gene	forms|nmod|START_ENTITY maturation|nmod|forms distribution|nmod|maturation distribution|appos|END_ENTITY	Differential distribution and response to experimental sexual maturation of two forms of brain gonadotropin-releasing_hormone -LRB- GnRH -RRB- in the European_eel , Anguilla_anguilla .
2535810	0	gonadotropin-releasing_hormone	58,88	GnRH	121,125	gonadotropin-releasing hormone	GnRH	MESH:D007987	25194(Tax:10116)	Chemical	Gene	inhibin|nmod|START_ENTITY effect|nmod|inhibin effect|acl|induced induced|dobj|up-regulation up-regulation|nmod|sites sites|amod|END_ENTITY	Inhibitory effect of pure 31-kilodalton bovine inhibin on gonadotropin-releasing_hormone -LRB- GnRH -RRB- - induced up-regulation of GnRH binding sites in cultured rat anterior pituitary cells .
2535810	0	gonadotropin-releasing_hormone	58,88	GnRH	90,94	gonadotropin-releasing hormone	GnRH	MESH:D007987	25194(Tax:10116)	Chemical	Gene	inhibin|nmod|START_ENTITY effect|nmod|inhibin effect|appos|END_ENTITY	Inhibitory effect of pure 31-kilodalton bovine inhibin on gonadotropin-releasing_hormone -LRB- GnRH -RRB- - induced up-regulation of GnRH binding sites in cultured rat anterior pituitary cells .
2676480	0	gonadotropin-releasing_hormone	17,47	GnRH	125,129	gonadotropin-releasing hormone	GnRH	MESH:D007987	2796	Chemical	Gene	form|nmod|START_ENTITY occurs|nsubj|form occurs|nmod|END_ENTITY	A second form of gonadotropin-releasing_hormone -LRB- GnRH -RRB- , with chicken GnRH_II-like properties , occurs together with mammalian GnRH in marsupial brains .
3282980	0	gonadotropin-releasing_hormone	12,42	GnRH	77,81	gonadotropin-releasing hormone	GnRH	MESH:D007987	2796	Chemical	Gene	Identity|nmod|START_ENTITY Identity|dep|comparison comparison|nmod|END_ENTITY	Identity of gonadotropin-releasing_hormone in passerine birds : comparison of GnRH in song sparrow -LRB- Melospiza melodia -RRB- and starling -LRB- Sturnus_vulgaris -RRB- with five vertebrate GnRHs .
3510152	0	gonadotropin-releasing_hormone	22,52	GnRH	54,58	gonadotropin-releasing hormone	GnRH	MESH:D007987	2796	Chemical	Gene	absorption|nmod|START_ENTITY absorption|appos|END_ENTITY	Topical absorption of gonadotropin-releasing_hormone -LRB- GnRH -RRB- in goldfish .
6086288	0	gonadotropin-releasing_hormone	10,40	GnRH	70,74	gonadotropin-releasing hormone	GnRH	MESH:D007987	25194(Tax:10116)	Chemical	Gene	responses|amod|START_ENTITY responses|nmod|END_ENTITY	Pituitary gonadotropin-releasing_hormone -LRB- GnRH -RRB- receptor responses to GnRH in hypothalamus-lesioned rats : inhibition of responses by hyperprolactinemia and evidence that testosterone and estradiol modulate gonadotropin secretion at postreceptor sites .
7528436	0	gonadotropin-releasing_hormone	6,36	GnRH	38,42	gonadotropin-releasing hormone	GnRH	MESH:D007987	2796	Chemical	Gene	superagonist|amod|START_ENTITY superagonist|appos|END_ENTITY	A new gonadotropin-releasing_hormone -LRB- GnRH -RRB- superagonist in goldfish : influence of dialkyl-D-homoarginine at position 6 on gonadotropin-II and growth_hormone release .
8026083	0	gonadotropin-releasing_hormone	30,60	GnRH	62,66	gonadotropin-releasing hormone	GnRH	MESH:D007987	2796	Chemical	Gene	origins|nmod|START_ENTITY origins|appos|END_ENTITY	Multiple embryonic origins of gonadotropin-releasing_hormone -LRB- GnRH -RRB- immunoreactive neurons .
8167236	0	gonadotropin-releasing_hormone	12,42	GnRH	44,48	gonadotropin-releasing hormone	GnRH	MESH:D007987	2796	Chemical	Gene	sites|amod|START_ENTITY sites|appos|END_ENTITY	Presence of gonadotropin-releasing_hormone -LRB- GnRH -RRB- binding sites and compounds with GnRH-like activity in the ovary of African catfish , Clarias gariepinus .
8706041	1	gonadotropin-releasing_hormone	163,193	GnRH	195,199	gonadotropin-releasing hormone	GnRH	MESH:D007987	2796	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|appos|END_ENTITY	The aim of the study was to test in vivo the gonadotropin-releasing_hormone -LRB- GnRH -RRB- antagonists and their conjugates showing antitumor activities in vitro .
9268117	0	gonadotropin-releasing_hormone	94,124	GnRH	126,130	gonadotropin-releasing hormone	GnRH	MESH:D007987	613033(Tax:9544)	Chemical	Gene	reaugmentation|nmod|START_ENTITY correlates|nmod|reaugmentation studies|nmod|correlates studies|appos|END_ENTITY	Ultrastructural studies of neuronal correlates of the pubertal reaugmentation of hypothalamic gonadotropin-releasing_hormone -LRB- GnRH -RRB- release in the rhesus_monkey -LRB- Macaca_mulatta -RRB- .
9390014	0	gonadotropin-releasing_hormone	14,44	GnRH	46,50	gonadotropin-releasing hormone	GnRH	MESH:D007987	2796	Chemical	Gene	functions|amod|START_ENTITY functions|appos|END_ENTITY	Evidence that gonadotropin-releasing_hormone -LRB- GnRH -RRB- functions as a prolactin-releasing factor in a teleost fish -LRB- Oreochromis_mossambicus -RRB- and primary structures for three native GnRH molecules .
9473680	0	gonadotropin-releasing_hormone	27,57	GnRH	162,166	gonadotropin-releasing hormone	GnRH	MESH:D007987	25194(Tax:10116)	Chemical	Gene	_|amod|START_ENTITY regulation|nmod|_ _|nsubj|regulation _|nmod|hormones hormones|dep|implication implication|nmod|activity activity|compound|END_ENTITY	Differential regulation of gonadotropin-releasing_hormone _ -LRB- GnRH -RRB- _ receptor expression in the posterior mediobasal hypothalamus by steroid hormones : implication of GnRH neuronal activity .
9724045	0	gonadotropin-releasing_hormone	30,60	GnRH	85,89	gonadotropin-releasing hormone	GnRH	MESH:D007987	14714(Tax:10090)	Chemical	Gene	activation|nmod|START_ENTITY receptor|nsubj|activation receptor|nmod|END_ENTITY	Transcriptional activation of gonadotropin-releasing_hormone -LRB- GnRH -RRB- receptor gene by GnRH and cyclic_adenosine_monophosphate .
9788600	0	gonadotropin-releasing_hormone	85,115	GnRH	178,182	gonadotropin-releasing hormone	GnRH	MESH:D007987	2796	Chemical	Gene	_|amod|START_ENTITY expressing|dobj|_ line|acl|expressing growth|nmod|line Inhibition|nmod|growth _|nsubj|Inhibition _|nmod|GnRH GnRH|compound|END_ENTITY	Inhibition of growth and proliferation of EcRG293 cell line expressing high-affinity gonadotropin-releasing_hormone _ -LRB- GnRH -RRB- _ receptor under the control of an inducible promoter by GnRH agonist -LRB- D-Lys6 -RRB- GnRH and antagonist -LRB- Antide -RRB- .
9788600	0	gonadotropin-releasing_hormone	85,115	GnRH	199,203	gonadotropin-releasing hormone	GnRH	MESH:D007987	2796	Chemical	Gene	_|amod|START_ENTITY expressing|dobj|_ line|acl|expressing growth|nmod|line Inhibition|nmod|growth _|nsubj|Inhibition _|nmod|END_ENTITY	Inhibition of growth and proliferation of EcRG293 cell line expressing high-affinity gonadotropin-releasing_hormone _ -LRB- GnRH -RRB- _ receptor under the control of an inducible promoter by GnRH agonist -LRB- D-Lys6 -RRB- GnRH and antagonist -LRB- Antide -RRB- .
9886846	0	gonadotropin-releasing_hormone	30,60	GnRH	85,89	gonadotropin-releasing hormone	GnRH	MESH:D007987	25194(Tax:10116)	Chemical	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Transcriptional activation of gonadotropin-releasing_hormone -LRB- GnRH -RRB- receptor gene by GnRH : involvement of multiple signal transduction pathways .
21963228	0	gonadotropin-releasing_hormone	29,59	GnRH-a	95,101	gonadotropin-releasing hormone	GnRH-a	MESH:D007987	25194(Tax:10116)	Chemical	Gene	antagonist|amod|START_ENTITY antagonist|appos|END_ENTITY	Evaluation of the effects of gonadotropin-releasing_hormone antagonist -LRB- GnRH-ant -RRB- and agonist -LRB- GnRH-a -RRB- in the prevention of postoperative_adhesion formation in a rat model with immunohistochemical analysis .
12843188	0	gonadotropin-releasing_hormone	44,74	GnRHR	181,186	gonadotropin-releasing hormone	GnRHR	MESH:D007987	2798	Chemical	Gene	receptor|amod|START_ENTITY action|nmod|receptor mutants|nsubj|action mutants|dobj|trait trait|acl:relcl|coevolved coevolved|nmod|expression expression|nmod|END_ENTITY	Dominant-negative action of disease-causing gonadotropin-releasing_hormone receptor -LRB- GnRHR -RRB- mutants : a trait that potentially coevolved with decreased plasma membrane expression of GnRHR in humans .
12843188	0	gonadotropin-releasing_hormone	44,74	GnRHR	85,90	gonadotropin-releasing hormone	GnRHR	MESH:D007987	2798	Chemical	Gene	receptor|amod|START_ENTITY action|nmod|receptor action|appos|END_ENTITY	Dominant-negative action of disease-causing gonadotropin-releasing_hormone receptor -LRB- GnRHR -RRB- mutants : a trait that potentially coevolved with decreased plasma membrane expression of GnRHR in humans .
16721030	0	gonadotropin-releasing_hormone	24,54	ghrelin	11,18	gonadotropin-releasing hormone	ghrelin	MESH:D007987	59301(Tax:10116)	Chemical	Gene	secretion|compound|START_ENTITY END_ENTITY|nmod|secretion	Effects of ghrelin upon gonadotropin-releasing_hormone and gonadotropin secretion in adult female rats : in vivo and in vitro studies .
6253282	0	gonadotropin-releasing_hormone	28,58	luteinizing_hormone_receptor	71,99	gonadotropin-releasing hormone	luteinizing hormone receptor	MESH:D007987	25477(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Direct inhibitory effect of gonadotropin-releasing_hormone upon luteal luteinizing_hormone_receptor and steroidogenesis in hypophysectomized rats .
16339453	0	gonadotropin-releasing_hormone	35,65	metastin	8,16	gonadotropin-releasing hormone	metastin	MESH:D007987	289023(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY Role|nmod|release Role|nmod|END_ENTITY	Role of metastin in the release of gonadotropin-releasing_hormone from the hypothalamus of the male rat .
7735299	0	gonadotropin-releasing_hormone	57,87	neuropeptide_Y	39,53	gonadotropin-releasing hormone	neuropeptide Y	MESH:D007987	100301542(Tax:9986)	Chemical	Gene	secretion|amod|START_ENTITY effects|nmod|secretion effects|nmod|END_ENTITY	Hypothalamic site-dependent effects of neuropeptide_Y on gonadotropin-releasing_hormone secretion in rhesus_macaques .
11514356	0	gonadotropins	67,80	insulin-like_growth_factor-I	13,41	gonadotropins	insulin-like growth factor-I	MESH:D006062	100034198(Tax:9796)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of insulin-like_growth_factor-I and its interaction with gonadotropins , estradiol , and fetal calf serum on in vitro maturation and parthenogenic development in equine oocytes .
26476415	0	gossypol	53,61	ATG5	65,69	gossypol	ATG5	MESH:D006072	9474	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Cytoprotective role of autophagy against BH3 mimetic gossypol in ATG5 knockout cells generated by CRISPR-Cas9 endonuclease .
6266011	0	gossypol	14,22	ATPase	26,32	gossypol	ATPase	MESH:D006072	1769	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|compound|END_ENTITY	The effect of gossypol on ATPase activity of the kidney .
20529838	0	gossypol	36,44	Bcl-2	4,9	gossypol	Bcl-2	MESH:D006072	596	Chemical	Gene	START_ENTITY|amod|homology homology|amod|END_ENTITY	The Bcl-2 homology domain 3 mimetic gossypol induces both Beclin_1-dependent and Beclin_1-independent cytoprotective autophagy in cancer cells .
3697356	0	gossypol	38,46	DNA_polymerase_alpha	14,34	gossypol	DNA polymerase alpha	MESH:D006072	5422	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of DNA_polymerase_alpha by gossypol .
12158558	0	gossypol	12,20	LDH-C4	65,71	gossypol	LDH-C4	MESH:D006072	3948	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	-LSB- Effects of gossypol on human specific lactate_dehydrogenase-C4 -LRB- LDH-C4 -RRB- -RSB- .
3447817	0	gossypol	10,18	LDH-X	60,65	gossypol	LDH-X	MESH:D006072	29634(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of gossypol on spermatozoal lactate_dehydrogenase-X -LRB- LDH-X -RRB- in male rats .
4077725	0	gossypol	23,31	LDH-X	14,19	gossypol	LDH-X	MESH:D006072	29634(Tax:10116)	Chemical	Gene	isomers|amod|START_ENTITY Inhibition|nmod|isomers Inhibition|nmod|END_ENTITY	Inhibition of LDH-X by gossypol optical isomers .
7168954	0	gossypol	43,51	LDH-X	25,30	gossypol	LDH-X	MESH:D006072	29634(Tax:10116)	Chemical	Gene	testis|nmod|START_ENTITY testis|dobj|activity activity|amod|END_ENTITY	Inhibition of rat testis LDH-X activity by gossypol .
9169468	0	gramoxone	58,67	apolipoprotein_A-I	20,38	gramoxone	apolipoprotein A-I	MESH:D010269	335	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of human apolipoprotein_A-I gene expression by gramoxone .
14632314	0	granisetron	11,22	5-HT3_receptor	26,40	granisetron	5-HT3 receptor	MESH:D017829	79246(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|antagonist antagonist|amod|END_ENTITY	Effects of granisetron , a 5-HT3_receptor antagonist , on 5-hydroxytryptamine -LRB- 5-HT -RRB- release from the isolated ileum in a delayed-emesis rat model .
7566499	0	granisetron	95,106	5-HT3_receptor	43,57	granisetron	5-HT3 receptor	MESH:D017829	79246(Tax:10116)	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|amod|END_ENTITY	Comparative study of the affinities of the 5-HT3_receptor antagonists , YM060 , YM114 -LRB- KAE-393 -RRB- , granisetron and ondansetron in rat vagus nerve and cerebral cortex .
20646986	0	granisetron	40,51	5HT3_receptor	15,28	granisetron	5HT3 receptor	MESH:D017829	79246(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|antagonist antagonist|amod|END_ENTITY	The effects of 5HT3_receptor antagonist granisetron on inflammatory parameters and angiogenesis in the air-pouch model of inflammation .
17582773	5	granulatimide	888,901	Chk1	867,871	granulatimide	Chk1	MESH:C433587	1111	Chemical	Gene	inhibitors|nmod|START_ENTITY inhibitors|amod|END_ENTITY	Some of the newly synthesized compounds are more potent Chk1 inhibitors than granulatimide .
25047935	0	granulatimide	10,23	Chk1	68,72	granulatimide	Chk1	MESH:C433587	1111	Chemical	Gene	analogues|amod|START_ENTITY analogues|nmod|inhibitors inhibitors|amod|END_ENTITY	Design of granulatimide and isogranulatimide analogues as potential Chk1 inhibitors : Study of amino-platforms for their synthesis .
15333642	0	grapevine	122,131	ADH	104,107	grapevine	ADH	null	10327	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Involvement of ethylene signalling in a non-climacteric fruit : new elements regarding the regulation of ADH expression in grapevine .
20967449	0	grapevine	20,29	PR-1	0,4	grapevine	PR-1	null	100258414(Tax:29760)	Chemical	Gene	family|nmod|START_ENTITY family|compound|END_ENTITY	PR-1 gene family of grapevine : a uniquely duplicated PR-1 gene from a Vitis interspecific hybrid confers high level resistance to bacterial_disease in transgenic tobacco .
14504909	1	grapevine	87,96	stilbene_synthase	59,76	grapevine	stilbene synthase	null	100256566(Tax:29760)	Chemical	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	with the stilbene_synthase gene from grapevine -LRB- Vitis_vinifera_L . -RRB-
26852874	0	graphene	82,90	CO2	56,59	graphene	CO2	MESH:D006108	717	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Synthesis , characterization and enhanced photocatalytic CO2 reduction activity of graphene supported TiO2 nanocrystals with coexposed -LCB- 001 -RCB- and -LCB- 101 -RCB- facets .
26460269	0	graphene	59,67	IFN-y	47,52	graphene	IFN-y	MESH:D006108	3458	Chemical	Gene	using|dobj|START_ENTITY END_ENTITY|acl|using	An electrochemical aptasensor for detection of IFN-y using graphene and a dual signal amplification strategy based on the exonuclease-mediated surface-initiated enzymatic polymerization .
25919809	0	graphene	36,44	Interferon_gamma	13,29	graphene	Interferon gamma	MESH:D006108	3458	Chemical	Gene	using|dobj|START_ENTITY END_ENTITY|acl|using	Detection of Interferon_gamma using graphene and aptamer based FET-like electrochemical biosensor .
25448622	0	graphene	74,82	prostate-specific_antigen	39,64	graphene	prostate-specific antigen	MESH:D006108	354	Chemical	Gene	based|nmod|START_ENTITY END_ENTITY|acl|based	Label electrochemical immunosensor for prostate-specific_antigen based on graphene and silver hybridized mesoporous silica .
15131241	0	grepafloxacin	129,142	multidrug_resistance-associated_protein_1	28,69	grepafloxacin	multidrug resistance-associated protein 1	MESH:C075375	17250(Tax:10090)	Chemical	Gene	involvement|nmod|START_ENTITY involvement|nmod|END_ENTITY	Differential involvement of multidrug_resistance-associated_protein_1 and P-glycoprotein in tissue distribution and excretion of grepafloxacin in mice .
11796340	0	grepafloxacin	84,97	multidrug_resistance-associated_protein_2	15,56	grepafloxacin	multidrug resistance-associated protein 2	MESH:C075375	25303(Tax:10116)	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of multidrug_resistance-associated_protein_2 in intestinal secretion of grepafloxacin in rats .
21180140	0	gsh	62,65	glucose-6-phosphate_dehydrogenase	11,44	gsh	glucose-6-phosphate dehydrogenase	CHEBI:16856	2539	Chemical	Gene	level|compound|START_ENTITY END_ENTITY|nmod|level	-LSB- Effect of glucose-6-phosphate_dehydrogenase on intracellular gsh level in Raji cells during oxidative stress -RSB- .
813080	0	guaiacol	85,93	lipoxygenase	53,65	guaiacol	lipoxygenase	MESH:D006139	547836(Tax:3847)	Chemical	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	Conversion of linoleic_acid_hydroperoxide by soybean lipoxygenase in the presence of guaiacol : identification of the reaction products .
21669270	0	guaianolide	89,100	iNOS	105,109	guaianolide	iNOS	null	18126(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Anti-inflammatory activity of Eupatorium perfoliatum L. extracts , eupafolin , and dimeric guaianolide via iNOS inhibitory activity and modulation of inflammation-related cytokines and chemokines .
16123122	0	guanidine	32,41	Hsp104	58,64	guanidine	Hsp104	MESH:D019791	850633(Tax:4932)	Chemical	Gene	inactivation|amod|START_ENTITY inactivation|nmod|END_ENTITY	Curing of yeast -LSB- PSI + -RSB- prion by guanidine inactivation of Hsp104 does not require cell division .
16599182	0	guanidine	13,22	PrP	100,103	guanidine	PrP	MESH:D019791	5621	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of guanidine on proteinase K resistance in vitro and infectivity of scrapie prion protein PrP -LRB- Sc -RRB- .
23590118	0	guanidine_HCl	56,69	cytochrome_c	40,52	guanidine HCl	cytochrome c	null	54205	Chemical	Gene	Dynamics|nmod|START_ENTITY Dynamics|nmod|END_ENTITY	Dynamics of geminate rebinding of CO to cytochrome_c in guanidine_HCl probed by femtosecond vibrational spectroscopy .
11442834	0	guanidine_hydrochloride	45,68	Hsp104	86,92	guanidine hydrochloride	Hsp104	MESH:D019791	850633(Tax:4932)	Chemical	Gene	prion|nmod|START_ENTITY elimination|nmod|prion result|nsubj|elimination result|nmod|inactivation inactivation|amod|END_ENTITY	The elimination of the yeast -LSB- PSI + -RSB- prion by guanidine_hydrochloride is the result of Hsp104 inactivation .
8639708	0	guanidine_hydrochloride	96,119	RNase_A	63,70	guanidine hydrochloride	RNase A	MESH:D019791	282340(Tax:9913)	Chemical	Gene	concentrations|nmod|START_ENTITY END_ENTITY|nmod|concentrations	Conformational changes at the active site of bovine pancreatic RNase_A at low concentrations of guanidine_hydrochloride probed by pyridoxal_5 ' - phosphate .
223644	0	guanidine_hydrochloride	88,111	apolipoprotein_A-I	16,34	guanidine hydrochloride	apolipoprotein A-I	MESH:D019791	281632(Tax:9913)	Chemical	Gene	Dissociation|nmod|START_ENTITY Dissociation|nmod|END_ENTITY	Dissociation of apolipoprotein_A-I from porcine and bovine high density lipoproteins by guanidine_hydrochloride .
12751820	0	guanidine_hydrochloride	28,51	disulfide_isomerase	107,126	guanidine hydrochloride	disulfide isomerase	MESH:D019791	79770	Chemical	Gene	mechanism|nmod|START_ENTITY END_ENTITY|nsubj|mechanism	The inhibition mechanism of guanidine_hydrochloride on the catalytic activity of recombinant human protein disulfide_isomerase .
8002014	0	guanidine_hydrochloride	15,38	lipase	81,87	guanidine hydrochloride	lipase	MESH:D019791	543006(Tax:4565)	Chemical	Gene	Interaction|nmod|START_ENTITY END_ENTITY|nsubj|Interaction	Interaction of guanidine_hydrochloride and guanidine_thiocyanate with wheat germ lipase .
12495428	0	guanidine_hydrochloride	96,119	thyroglobulin	59,72	guanidine hydrochloride	thyroglobulin	MESH:D019791	280706(Tax:9913)	Chemical	Gene	Evidence|nmod|START_ENTITY Evidence|nmod|END_ENTITY	Evidence for the existence of an unfolding intermediate of thyroglobulin during denaturation by guanidine_hydrochloride .
14668331	0	guanidinium_chloride	23,43	Hsp104	84,90	guanidinium chloride	Hsp104	MESH:D019791	850633(Tax:4932)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	The prion curing agent guanidinium_chloride specifically inhibits ATP hydrolysis by Hsp104 .
10852709	0	guanidinium_chloride	113,133	cytochrome_b	74,86	guanidinium chloride	cytochrome b	MESH:D019791	4519	Chemical	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	Monitoring mobility in the early steps of unfolding : the case of oxidized cytochrome_b -LRB- 5 -RRB- in the presence of 2 M guanidinium_chloride .
9836603	0	guanidinium_chloride	83,103	cytochrome_b5	46,59	guanidinium chloride	cytochrome b5	MESH:D019791	64001(Tax:10116)	Chemical	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	Solution structure of oxidized rat microsomal cytochrome_b5 in the presence of 2 M guanidinium_chloride : monitoring the early steps in protein unfolding .
2665903	0	guanidinoethylmercaptosuccinic_acid	102,137	enkephalin_convertase	178,199	guanidinoethylmercaptosuccinic acid	enkephalin convertase	MESH:C022014	25669(Tax:10116)	Chemical	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	In vivo modulation of rat hypothalamic opioid peptide content by intracerebroventricular injection of guanidinoethylmercaptosuccinic_acid -LRB- GEMSA -RRB- : possible physiological role of enkephalin_convertase .
3102992	0	guanidinoethylmercaptosuccinic_acid	36,71	enkephalin_convertase	90,111	guanidinoethylmercaptosuccinic acid	enkephalin convertase	MESH:C022014	25669(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|inhibitor inhibitor|compound|END_ENTITY	Analgesic and convulsant effects of guanidinoethylmercaptosuccinic_acid -LRB- GEMSA -RRB- -- a potent enkephalin_convertase inhibitor .
4005847	0	guanine	219,226	C-8	204,207	guanine	C-8	MESH:D006147	14793(Tax:10090)	Chemical	Gene	residues|amod|START_ENTITY END_ENTITY|nmod|residues	Further characterization of the DNA adducts formed by electrophilic esters of the hepatocarcinogens 1 ' - hydroxysafrole and 1 ' - hydroxyestragole in vitro and in mouse liver in vivo , including new adducts at C-8 and N-7 of guanine residues .
21107991	0	guanine	30,37	HLA-DRB1	215,223	guanine	HLA-DRB1	MESH:D006147	3123	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	Contribution of an adenine to guanine single nucleotide polymorphism of the matrix_metalloproteinase-13 -LRB- MMP-13 -RRB- -77 promoter region to the production of anticyclic citrullinated peptide antibodies in patients with HLA-DRB1 * shared epitope-negative rheumatoid_arthritis .
19118547	1	guanine	149,156	Rac1	176,180	guanine	p130	MESH:D006147	9221	Chemical	Gene	factor|amod|START_ENTITY factor|nmod|END_ENTITY	DOCK180 is a guanine exchange factor of Rac1 originally identified as a protein bound to an SH3 domain of the Crk adaptor protein .
16413273	0	guanine_nucleotide	29,47	ADP-ribosylation_factor_6	68,93	guanine nucleotide	ADP-ribosylation factor 6	CHEBI:61292	382	Chemical	Gene	factor|amod|START_ENTITY factor|nmod|END_ENTITY	Functional assay of EFA6A , a guanine_nucleotide exchange factor for ADP-ribosylation_factor_6 -LRB- ARF6 -RRB- , in dendritic formation of hippocampal neurons .
17298598	0	guanine_nucleotide	41,59	ADP-ribosylation_factor_6	80,105	guanine nucleotide	ADP-ribosylation factor 6	CHEBI:61292	382	Chemical	Gene	factor|amod|START_ENTITY factor|nmod|END_ENTITY	Somatodendritic localization of EFA6A , a guanine_nucleotide exchange factor for ADP-ribosylation_factor_6 , and its possible interaction with alpha-actinin in dendritic spines .
20601426	0	guanine_nucleotide	4,22	ADP-ribosylation_factor_6	44,69	guanine nucleotide	ADP-ribosylation factor 6	CHEBI:61292	382	Chemical	Gene	protein|amod|START_ENTITY protein|nmod|END_ENTITY	The guanine_nucleotide exchange protein for ADP-ribosylation_factor_6 , ARF-GEP100 / BRAG2 , regulates phagocytosis of monocytic phagocytes in an ARF6-dependent process .
9417041	0	guanine_nucleotide	10,28	ADP-ribosylation_factor_6	49,74	guanine nucleotide	ADP-ribosylation factor 6	CHEBI:61292	382	Chemical	Gene	factor|amod|START_ENTITY factor|nmod|END_ENTITY	ARNO is a guanine_nucleotide exchange factor for ADP-ribosylation_factor_6 .
18323689	0	guanine_nucleotide	17,35	ADP_ribosylation_factor_6	57,82	guanine nucleotide	ADP ribosylation factor 6	CHEBI:61292	11845(Tax:10090)	Chemical	Gene	factors|amod|START_ENTITY factors|nmod|END_ENTITY	The EFA6 family : guanine_nucleotide exchange factors for ADP_ribosylation_factor_6 at neuronal synapses .
17981261	0	guanine_nucleotide	68,86	ARF1	107,111	guanine nucleotide	ARF1	CHEBI:61292	375	Chemical	Gene	factor|amod|START_ENTITY factor|nmod|END_ENTITY	Identification of a neuron-specific human gene , KIAA1110 , that is a guanine_nucleotide exchange factor for ARF1 .
16707115	0	guanine_nucleotide	47,65	ARF6	86,90	guanine nucleotide	ARF6	CHEBI:61292	11845(Tax:10090)	Chemical	Gene	factor|amod|START_ENTITY factor|nmod|END_ENTITY	Distinct spatiotemporal expression of EFA6D , a guanine_nucleotide exchange factor for ARF6 , among the EFA6 family in mouse brain .
18708035	0	guanine_nucleotide	37,55	ARF6	76,80	guanine nucleotide	ARF6	CHEBI:61292	11845(Tax:10090)	Chemical	Gene	factor|amod|START_ENTITY factor|nmod|END_ENTITY	Predominant localization of EFA6A , a guanine_nucleotide exchange factor for ARF6 , at the perisynaptic photoreceptor processes .
19085064	0	guanine_nucleotide	25,43	ARF6	64,68	guanine nucleotide	ARF6	CHEBI:61292	11845(Tax:10090)	Chemical	Gene	factor|amod|START_ENTITY factor|nmod|END_ENTITY	Localization of EFA6A , a guanine_nucleotide exchange factor for ARF6 , in spermatogenic cells of testes of adult mice .
17766704	0	guanine_nucleotide	48,66	ARHGEF12	84,92	guanine nucleotide	ARHGEF12	CHEBI:61292	23365	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic variants in the leukemia-associated Rho guanine_nucleotide exchange factor -LRB- ARHGEF12 -RRB- gene are not associated with T2DM and related parameters in Caucasians -LRB- KORA study -RRB- .
12831845	0	guanine_nucleotide	30,48	Albumin	0,7	guanine nucleotide	Albumin	CHEBI:61292	213	Chemical	Gene	inhibitor|amod|START_ENTITY END_ENTITY|dep|inhibitor	Albumin : a Galpha -LRB- s -RRB- - specific guanine_nucleotide dissociation inhibitor and GTPase activating protein .
18164504	0	guanine_nucleotide	21,39	Arf6	60,64	guanine nucleotide	Arf6	CHEBI:61292	11845(Tax:10090)	Chemical	Gene	factor|amod|START_ENTITY factor|nmod|END_ENTITY	IQ-ArfGEF/BRAG1 is a guanine_nucleotide exchange factor for Arf6 that interacts with PSD-95 at postsynaptic density of excitatory synapses .
21198641	0	guanine_nucleotide	15,33	Arf6	54,58	guanine nucleotide	Arf6	CHEBI:61292	382	Chemical	Gene	factor|amod|START_ENTITY factor|nmod|END_ENTITY	SynArfGEF is a guanine_nucleotide exchange factor for Arf6 and localizes preferentially at post-synaptic specializations of inhibitory synapses .
24261326	0	guanine_nucleotide	9,27	Arf6	48,52	guanine nucleotide	Arf6	CHEBI:61292	11845(Tax:10090)	Chemical	Gene	factor|amod|START_ENTITY factor|nmod|END_ENTITY	EFA6A , a guanine_nucleotide exchange factor for Arf6 , interacts with sorting_nexin-1 and regulates neurite outgrowth .
19628279	0	guanine_nucleotide	17,35	Asef	52,56	guanine nucleotide	Asef	CHEBI:61292	50649	Chemical	Gene	functions|compound|START_ENTITY functions|compound|END_ENTITY	The RAC specific guanine_nucleotide exchange factor Asef functions downstream from TEL-AML1 to promote leukaemic transformation .
11292831	6	guanine_nucleotide	978,996	CalDAG-GEFI	1016,1027	guanine nucleotide	CalDAG-GEFI	CHEBI:61292	361714(Tax:10116)	Chemical	Gene	I|amod|START_ENTITY I|appos|END_ENTITY	Using specific antibodies , we show that a recently identified Rap1 GEF , calcium - and diacylglycerol-regulated guanine_nucleotide exchange factor I -LRB- CalDAG-GEFI -RRB- , is expressed in PC12D cells and that carbachol stimulates the formation of a complex containing CalDAG-GEFI , Rap1 , and activated B-Raf .
11278453	0	guanine_nucleotide	23,41	CalDAG-GEF_I	57,69	guanine nucleotide	CalDAG-GEF I	CHEBI:61292	19395(Tax:10090)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Activation of the Rap1 guanine_nucleotide exchange gene , CalDAG-GEF_I , in BXH-2 murine myeloid_leukemia .
16714282	0	guanine_nucleotide	38,56	Caveolin-1	0,10	guanine nucleotide	Caveolin-1	CHEBI:61292	857	Chemical	Gene	START_ENTITY|nsubj|functions functions|amod|END_ENTITY	Caveolin-1 functions as a novel Cdc42 guanine_nucleotide dissociation inhibitor in pancreatic beta-cells .
10094633	0	guanine_nucleotide	35,53	Cdc25p	77,83	guanine nucleotide	Cdc25p	CHEBI:61292	851019(Tax:4932)	Chemical	Gene	factor|amod|START_ENTITY factor|nmod|END_ENTITY	Ssa1p chaperone interacts with the guanine_nucleotide exchange factor of ras Cdc25p and controls the cAMP pathway in Saccharomyces_cerevisiae .
21073870	0	guanine_nucleotide	28,46	Cdc25p	86,92	guanine nucleotide	Cdc25p	CHEBI:61292	851019(Tax:4932)	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Feedback regulation of Ras2 guanine_nucleotide exchange factor -LRB- Ras2-GEF -RRB- activity of Cdc25p by Cdc25p phosphorylation in the yeast Saccharomyces_cerevisiae .
10559246	0	guanine_nucleotide	49,67	Cdc42	97,102	guanine nucleotide	Cdc42	CHEBI:61292	998	Chemical	Gene	specific|amod|START_ENTITY specific|nmod|END_ENTITY	Identification and characterization of hPEM-2 , a guanine_nucleotide exchange factor specific for Cdc42 .
11181572	0	guanine_nucleotide	16,34	Cdc42	10,15	guanine nucleotide	Cdc42	CHEBI:61292	12540(Tax:10090)	Chemical	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	Fgd1 , the Cdc42 guanine_nucleotide exchange factor responsible for faciogenital_dysplasia , is localized to the subcortical actin cytoskeleton and Golgi membrane .
15743413	0	guanine_nucleotide	94,112	Cdc42	88,93	guanine nucleotide	Cdc42	CHEBI:61292	998	Chemical	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	The FWD1/beta-TrCP-mediated degradation pathway establishes a ` turning off switch ' of a Cdc42 guanine_nucleotide exchange factor , FGD1 .
20045932	0	guanine_nucleotide	102,120	Cdc42	96,101	guanine nucleotide	Cdc42	CHEBI:61292	998	Chemical	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	Proline-rich domain plays a crucial role in extracellular stimuli-responsive translocation of a Cdc42 guanine_nucleotide exchange factor , FGD1 .
21212517	0	guanine_nucleotide	22,40	Cdc42	16,21	guanine nucleotide	Cdc42	CHEBI:61292	998	Chemical	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	Role of FGD1 , a Cdc42 guanine_nucleotide exchange factor , in epidermal growth factor-stimulated c-Jun NH2-terminal kinase activation and cell migration .
16423831	0	guanine_nucleotide	42,60	E-cadherin	150,160	guanine nucleotide	E-cadherin	CHEBI:61292	83502(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|endocytosis endocytosis|nmod|END_ENTITY	Involvement of the Ras-Ras-activated Rab5 guanine_nucleotide exchange factor RIN2-Rab5 pathway in the hepatocyte_growth_factor-induced endocytosis of E-cadherin .
10493796	0	guanine_nucleotide	53,71	EF-1_alpha	99,109	guanine nucleotide	EF-1 alpha	CHEBI:61292	24888902	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	A chimeric elongation factor containing the putative guanine_nucleotide binding domain of archaeal EF-1_alpha and the M and C domains of eubacterial EF-Tu .
17671188	0	guanine_nucleotide	36,54	ELMO1	0,5	guanine nucleotide	ELMO1	CHEBI:61292	9844	Chemical	Gene	factor|compound|START_ENTITY END_ENTITY|appos|factor	ELMO1 and Dock180 , a bipartite Rac1 guanine_nucleotide exchange factor , promote human glioma cell invasion .
22172673	5	guanine_nucleotide	619,637	Ect2	682,686	guanine nucleotide	Ect2	CHEBI:61292	1894	Chemical	Gene	function|amod|START_ENTITY function|nmod|END_ENTITY	Both guanine_nucleotide exchange function and membrane targeting of Ect2 are essential for RhoA activation and cleavage furrow formation in human cells .
16316996	0	guanine_nucleotide	9,27	Epac2	44,49	guanine nucleotide	Epac2	CHEBI:61292	11069	Chemical	Gene	cyclic_AMP|amod|START_ENTITY cyclic_AMP|compound|END_ENTITY	The RAP1 guanine_nucleotide exchange factor Epac2 couples cyclic_AMP and Ras signals at the plasma membrane .
3079907	0	guanine_nucleotide	155,173	Epidermal_growth_factor	0,23	guanine nucleotide	Epidermal growth factor	CHEBI:61292	1950	Chemical	Gene	complex|amod|START_ENTITY subunit|nmod|complex relationship|nmod|subunit END_ENTITY|dep|relationship	Epidermal_growth_factor -LRB- urogastrone -RRB- - mediated phosphorylation of a 35-kDa substrate in human placental membranes : relationship to the beta subunit of the guanine_nucleotide regulatory complex .
6610834	0	guanine_nucleotide	35,53	Epidermal_growth_factor	0,23	guanine nucleotide	Epidermal growth factor	CHEBI:61292	1950	Chemical	Gene	START_ENTITY|nsubj|stimulates stimulates|compound|END_ENTITY	Epidermal_growth_factor stimulates guanine_nucleotide binding activity and phosphorylation of ras oncogene proteins .
15322108	0	guanine_nucleotide	19,37	GEFT	0,4	guanine nucleotide	GEFT	CHEBI:61292	115557	Chemical	Gene	factor|compound|START_ENTITY END_ENTITY|appos|factor	GEFT , a Rho family guanine_nucleotide exchange factor , regulates neurite outgrowth and dendritic spine formation .
21663592	0	guanine_nucleotide	19,37	GEFT	0,4	guanine nucleotide	GEFT	CHEBI:61292	52666(Tax:10090)	Chemical	Gene	factor|compound|START_ENTITY END_ENTITY|appos|factor	GEFT , A Rho family guanine_nucleotide exchange factor , regulates lens differentiation through a Rac1-mediated mechanism .
10486569	0	guanine_nucleotide	33,51	GFR	20,23	guanine nucleotide	GFR	CHEBI:61292	9771	Chemical	Gene	START_ENTITY|nsubj|Characterization Characterization|nmod|END_ENTITY	Characterization of GFR , a novel guanine_nucleotide exchange factor for Rap1 .
17034816	0	guanine_nucleotide	92,110	GNL3L	128,133	guanine nucleotide	GNL3L	CHEBI:61292	54552	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	A novel lysine-rich domain and GTP binding motifs regulate the nucleolar retention of human guanine_nucleotide binding protein , GNL3L .
11149419	0	guanine_nucleotide	20,38	GSalpha	56,63	guanine nucleotide	GSalpha	CHEBI:61292	2778	Chemical	Gene	START_ENTITY|dobj|protein protein|appos|END_ENTITY	Role of stimulatory guanine_nucleotide binding protein -LRB- GSalpha -RRB- in proliferation of PC-3M prostate_cancer cells .
19847316	0	guanine_nucleotide	25,43	Galpha	10,16	guanine nucleotide	Galpha	CHEBI:61292	8802	Chemical	Gene	START_ENTITY|nsubj|protein protein|compound|END_ENTITY	Ric-8A , a Galpha protein guanine_nucleotide exchange factor potentiates taste receptor signaling .
14749369	0	guanine_nucleotide	70,88	H-Ras	14,19	guanine nucleotide	H-Ras	CHEBI:61292	3265	Chemical	Gene	START_ENTITY|nsubj|Activation Activation|nmod|END_ENTITY	Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine_nucleotide exchange factors .
11823862	0	guanine_nucleotide	43,61	PIKE	101,105	guanine nucleotide	PIKE	CHEBI:61292	116986	Chemical	Gene	factor|amod|START_ENTITY factor|nmod|END_ENTITY	Phospholipase_C_gamma_1 is a physiological guanine_nucleotide exchange factor for the nuclear GTPase PIKE .
23572525	0	guanine_nucleotide	30,48	Plekhg4	0,7	guanine nucleotide	Plekhg4	CHEBI:61292	102075(Tax:10090)	Chemical	Gene	protein|compound|START_ENTITY protein|nsubj|END_ENTITY	Plekhg4 is a novel Dbl family guanine_nucleotide exchange factor protein for rho family GTPases .
10608844	0	guanine_nucleotide	22,40	RA-GEF	0,6	guanine nucleotide	RA-GEF	CHEBI:61292	9693	Chemical	Gene	factor|compound|START_ENTITY END_ENTITY|appos|factor	RA-GEF , a novel Rap1A guanine_nucleotide exchange factor containing a Ras/Rap1A-associating domain , is conserved between nematode and humans .
16316996	0	guanine_nucleotide	9,27	RAP1	4,8	guanine nucleotide	RAP1	CHEBI:61292	5906	Chemical	Gene	cyclic_AMP|amod|START_ENTITY cyclic_AMP|compound|END_ENTITY	The RAP1 guanine_nucleotide exchange factor Epac2 couples cyclic_AMP and Ras signals at the plasma membrane .
11703925	0	guanine_nucleotide	50,68	RIN1	90,94	guanine nucleotide	RIN1	CHEBI:61292	9610	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Ras-activated endocytosis is mediated by the Rab5 guanine_nucleotide exchange activity of RIN1 .
24719330	0	guanine_nucleotide	22,40	Rab12	74,79	guanine nucleotide	Rab12	CHEBI:61292	19328(Tax:10090)	Chemical	Gene	factor|amod|START_ENTITY factor|nmod|END_ENTITY	Dennd3 functions as a guanine_nucleotide exchange factor for small GTPase Rab12 in mouse embryonic fibroblasts .
16525121	0	guanine_nucleotide	16,34	Rab21	10,15	guanine nucleotide	Rab21	CHEBI:61292	23011	Chemical	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	Varp is a Rab21 guanine_nucleotide exchange factor and regulates endosome dynamics .
23702376	0	guanine_nucleotide	33,51	Rab27	72,77	guanine nucleotide	Rab27	CHEBI:61292	50645(Tax:10116)	Chemical	Gene	factor|amod|START_ENTITY factor|nmod|END_ENTITY	MADD/DENN/Rab3GEP functions as a guanine_nucleotide exchange factor for Rab27 during granule exocytosis of rat parotid acinar cells .
18559336	0	guanine_nucleotide	29,47	Rab27a	68,74	guanine nucleotide	Rab27a	CHEBI:61292	5873	Chemical	Gene	factor|amod|START_ENTITY factor|nmod|END_ENTITY	Rab3GEP is the non-redundant guanine_nucleotide exchange factor for Rab27a in melanocytes .
27022630	6	guanine_nucleotide	903,921	Rab3	948,952	guanine nucleotide	Rab3	CHEBI:61292	36127(Tax:7227)	Chemical	Gene	factor|amod|START_ENTITY factor|nmod|END_ENTITY	As the Drosophila homologue of mammalian DENN/MADD and Caenorhabditis_elegans AEX-3 , Rab3-GEF is a guanine_nucleotide exchange factor -LRB- GEF -RRB- for Rab3 that stimulates GDP to GTP exchange .
17189207	0	guanine_nucleotide	17,35	Rab31	11,16	guanine nucleotide	Rab31	CHEBI:61292	11031	Chemical	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	Gapex-5 , a Rab31 guanine_nucleotide exchange factor that regulates Glut4 trafficking in adipocytes .
21586568	0	guanine_nucleotide	30,48	Rab31	95,100	guanine nucleotide	Rab31	CHEBI:61292	11031	Chemical	Gene	factor|amod|START_ENTITY factor|nmod|END_ENTITY	Characterization of RIN3 as a guanine_nucleotide exchange factor for the Rab5 subfamily GTPase Rab31 .
20154091	0	guanine_nucleotide	29,47	Rab35	23,28	guanine nucleotide	Rab35	CHEBI:61292	11021	Chemical	Gene	factors|amod|START_ENTITY factors|amod|END_ENTITY	The connecdenn family , Rab35 guanine_nucleotide exchange factors interfacing with the clathrin machinery .
11516400	0	guanine_nucleotide	20,38	Rab3A	59,64	guanine nucleotide	Rab3A	CHEBI:61292	25531(Tax:10116)	Chemical	Gene	factor|amod|START_ENTITY factor|nmod|END_ENTITY	GRAB : a physiologic guanine_nucleotide exchange factor for Rab3A , which interacts with inositol_hexakisphosphate kinase .
11703925	0	guanine_nucleotide	50,68	Rab5	45,49	guanine nucleotide	Rab5	CHEBI:61292	5868	Chemical	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Ras-activated endocytosis is mediated by the Rab5 guanine_nucleotide exchange activity of RIN1 .
12837691	0	guanine_nucleotide	14,32	Rab5	70,74	guanine nucleotide	Rab5	CHEBI:61292	5868	Chemical	Gene	factor|amod|START_ENTITY factor|nmod|END_ENTITY	ALS2 , a novel guanine_nucleotide exchange factor for the small GTPase Rab5 , is implicated in endosomal dynamics .
21419809	0	guanine_nucleotide	52,70	Rab5a	91,96	guanine nucleotide	Rab5a	CHEBI:61292	5868	Chemical	Gene	factor|amod|START_ENTITY factor|nmod|END_ENTITY	Rin-like , a novel regulator of endocytosis , acts as guanine_nucleotide exchange factor for Rab5a and Rab22 .
25535387	0	guanine_nucleotide	19,37	Rab8	14,18	guanine nucleotide	Rab8	CHEBI:61292	4218	Chemical	Gene	START_ENTITY|nsubj|Activation Activation|nmod|END_ENTITY	Activation of Rab8 guanine_nucleotide exchange factor Rabin8 by ERK1/2 in response to EGF signaling .
11707441	0	guanine_nucleotide	28,46	Rac1	67,71	guanine nucleotide	Rac1	CHEBI:61292	19353(Tax:10090)	Chemical	Gene	factor|amod|START_ENTITY factor|nmod|END_ENTITY	Characterization of STEF , a guanine_nucleotide exchange factor for Rac1 , required for neurite growth .
12626503	0	guanine_nucleotide	116,134	Rac1	155,159	guanine nucleotide	Rac1	CHEBI:61292	5879	Chemical	Gene	factor|amod|START_ENTITY factor|nmod|END_ENTITY	The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the beta_PIX guanine_nucleotide exchange factor for Rac1 and Cdc42 .
14550769	0	guanine_nucleotide	21,39	Rac1	61,65	guanine nucleotide	Rac1	CHEBI:61292	19353(Tax:10090)	Chemical	Gene	factors|amod|START_ENTITY factors|nmod|END_ENTITY	Roles of STEF/Tiam1 , guanine_nucleotide exchange factors for Rac1 , in regulation of growth cone morphology .
15033976	0	guanine_nucleotide	25,43	Rac1	20,24	guanine nucleotide	Rac1	CHEBI:61292	5879	Chemical	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	Alsin is a Rab5 and Rac1 guanine_nucleotide exchange factor .
17403664	0	guanine_nucleotide	9,27	Rac1	48,52	guanine nucleotide	Rac1	CHEBI:61292	5879	Chemical	Gene	factor|amod|START_ENTITY factor|nmod|END_ENTITY	Def-6 , a guanine_nucleotide exchange factor for Rac1 , interacts with the skeletal muscle integrin chain alpha7A and influences myoblast differentiation .
18045877	0	guanine_nucleotide	66,84	Rac1	105,109	guanine nucleotide	Rac1	CHEBI:61292	5879	Chemical	Gene	factor|amod|START_ENTITY factor|nmod|END_ENTITY	Heterotrimeric G protein betagamma subunits stimulate FLJ00018 , a guanine_nucleotide exchange factor for Rac1 and Cdc42 .
18930714	0	guanine_nucleotide	30,48	Rac1	69,73	guanine nucleotide	Rac1	CHEBI:61292	363875(Tax:10116)	Chemical	Gene	factor|amod|START_ENTITY factor|nmod|END_ENTITY	Regulatory roles for Tiam1 , a guanine_nucleotide exchange factor for Rac1 , in glucose-stimulated insulin secretion in pancreatic beta-cells .
26224100	0	guanine_nucleotide	8,26	Rac1	47,51	guanine nucleotide	Rac1	CHEBI:61292	363875(Tax:10116)	Chemical	Gene	factor|amod|START_ENTITY factor|nmod|END_ENTITY	VAV2 , a guanine_nucleotide exchange factor for Rac1 , regulates glucose-stimulated insulin secretion in pancreatic beta cells .
22106281	0	guanine_nucleotide	29,47	Rac2	85,89	guanine nucleotide	Rac2	CHEBI:61292	5880	Chemical	Gene	factor|amod|START_ENTITY factor|nmod|END_ENTITY	Phospholipase_D2 -LRB- PLD2 -RRB- is a guanine_nucleotide exchange factor -LRB- GEF -RRB- for the GTPase Rac2 .
10889189	0	guanine_nucleotide	49,67	Ral	88,91	guanine nucleotide	Ral	CHEBI:61292	5898	Chemical	Gene	factor|amod|START_ENTITY factor|nmod|END_ENTITY	RalGEF2 , a pleckstrin homology domain containing guanine_nucleotide exchange factor for Ral .
11046144	0	guanine_nucleotide	73,91	Ral	69,72	guanine nucleotide	Ral	CHEBI:61292	5898	Chemical	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Ras-dependent regulation of c-Jun phosphorylation is mediated by the Ral guanine_nucleotide exchange factor-Ral pathway .
17462626	0	guanine_nucleotide	41,59	RalGPS2	23,30	guanine nucleotide	RalGPS2	CHEBI:61292	78255(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|analysis analysis|nmod|END_ENTITY	Functional analysis of RalGPS2 , a murine guanine_nucleotide exchange factor for RalA GTPase .
10811801	0	guanine_nucleotide	32,50	Ran	70,73	guanine nucleotide	Ran	CHEBI:61292	5901	Chemical	Gene	factor|amod|START_ENTITY factor|nmod|END_ENTITY	The mammalian Mog1 protein is a guanine_nucleotide release factor for Ran .
10486569	0	guanine_nucleotide	33,51	Rap1	72,76	guanine nucleotide	Rap1	CHEBI:61292	27342	Chemical	Gene	START_ENTITY|dobj|factor factor|nmod|END_ENTITY	Characterization of GFR , a novel guanine_nucleotide exchange factor for Rap1 .
10608883	0	guanine_nucleotide	12,30	Rap1	60,64	guanine nucleotide	Rap1	CHEBI:61292	27342	Chemical	Gene	specific|amod|START_ENTITY specific|nmod|END_ENTITY	PDZ-GEF1 , a guanine_nucleotide exchange factor specific for Rap1 and Rap2 .
10934204	0	guanine_nucleotide	18,36	Rap1	69,73	guanine nucleotide	Rap1	CHEBI:61292	5906	Chemical	Gene	factors|amod|START_ENTITY Identification|nmod|factors Identification|nmod|GTPase GTPase|compound|END_ENTITY	Identification of guanine_nucleotide exchange factors -LRB- GEFs -RRB- for the Rap1 GTPase .
11278453	0	guanine_nucleotide	23,41	Rap1	18,22	guanine nucleotide	Rap1	CHEBI:61292	109905(Tax:10090)	Chemical	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Activation of the Rap1 guanine_nucleotide exchange gene , CalDAG-GEF_I , in BXH-2 murine myeloid_leukemia .
11359771	0	guanine_nucleotide	12,30	Rap1	115,119	guanine nucleotide	Rap1	CHEBI:61292	5906	Chemical	Gene	factor|amod|START_ENTITY RA-GEF-1|appos|factor activated|nsubjpass|RA-GEF-1 activated|nmod|translocation translocation|acl|induced induced|nmod|GTP GTP|compound|END_ENTITY	RA-GEF-1 , a guanine_nucleotide exchange factor for Rap1 , is activated by translocation induced by association with Rap1 * GTP and enhances Rap1-dependent B-Raf activation .
11359771	0	guanine_nucleotide	12,30	Rap1	51,55	guanine nucleotide	Rap1	CHEBI:61292	5906	Chemical	Gene	factor|amod|START_ENTITY factor|nmod|END_ENTITY	RA-GEF-1 , a guanine_nucleotide exchange factor for Rap1 , is activated by translocation induced by association with Rap1 * GTP and enhances Rap1-dependent B-Raf activation .
12581858	0	guanine_nucleotide	42,60	Rap1	91,95	guanine nucleotide	Rap1	CHEBI:61292	5906	Chemical	Gene	factors|amod|START_ENTITY family|nmod|factors PDZ-GEFs|appos|family Characterisation|nmod|PDZ-GEFs Characterisation|amod|specific specific|nmod|END_ENTITY	Characterisation of PDZ-GEFs , a family of guanine_nucleotide exchange factors specific for Rap1 and Rap2 .
15479739	0	guanine_nucleotide	47,65	Rap1	0,4	guanine nucleotide	Rap1	CHEBI:61292	5906	Chemical	Gene	factors|compound|START_ENTITY spreading|nmod|factors cell|acl|spreading promotes|dobj|cell promotes|nsubj|END_ENTITY	Rap1 promotes cell spreading by localizing Rac guanine_nucleotide exchange factors .
16912161	6	guanine_nucleotide	1158,1176	Rap1	1153,1157	guanine nucleotide	Rap1	CHEBI:61292	27342	Chemical	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	We also showed Rap1 and ERK activation by both hepatocyte_growth_factor -LRB- HGF -RRB- and 8CPT-2Me-cAMP -LRB- an activator of Epac , a Rap1 guanine_nucleotide exchange factor -RRB- in two human melanoma cell lines .
19159611	0	guanine_nucleotide	56,74	Rap1	51,55	guanine nucleotide	Rap1	CHEBI:61292	5906	Chemical	Gene	factors|amod|START_ENTITY factors|amod|END_ENTITY	Cell-cell junction formation : the role of Rap1 and Rap1 guanine_nucleotide exchange factors .
19433259	1	guanine_nucleotide	306,324	Rap1	345,349	guanine nucleotide	Epac	CHEBI:61292	35588(Tax:7227)	Chemical	Gene	factor|amod|START_ENTITY factor|nmod|END_ENTITY	Real-time quantitative reverse transcription polymerase chain reaction -LRB- qRT-PCR -RRB- was used to characterize the effects of juvenile_hormone -LRB- JH -RRB- on Epac -LRB- Exchange Protein directly Activated by Cyclic_AMP ; NM_001103732 -RRB- , a guanine_nucleotide exchange factor for Rap1 in Drosophila S2 cells .
19702438	0	guanine_nucleotide	30,48	Rap1	87,91	guanine nucleotide	Rap1	CHEBI:61292	5906	Chemical	Gene	factors|amod|START_ENTITY factors|nmod|END_ENTITY	Pharmacological activation of guanine_nucleotide exchange factors for the small GTPase Rap1 recruits high-affinity beta1 integrins as coreceptors for parvovirus_B19 : improved ex vivo gene transfer to human erythroid progenitor cells .
20209136	0	guanine_nucleotide	9,27	Rap1	4,8	guanine nucleotide	Rap1	CHEBI:61292	38244(Tax:7227)	Chemical	Gene	C3G|amod|START_ENTITY C3G|amod|END_ENTITY	The Rap1 guanine_nucleotide exchange factor C3G is required for preservation of larval muscle integrity in Drosophila_melanogaster .
20800573	0	guanine_nucleotide	30,48	Rap1	68,72	guanine nucleotide	Rap1	CHEBI:61292	54386	Chemical	Gene	factor|amod|START_ENTITY factor|nmod|END_ENTITY	BAG3 directly associates with guanine_nucleotide exchange factor of Rap1 , PDZGEF2 , and regulates cell adhesion .
24491570	0	guanine_nucleotide	41,59	Rap1	80,84	guanine nucleotide	Rap1	CHEBI:61292	109905(Tax:10090)	Chemical	Gene	factor|amod|START_ENTITY factor|nmod|END_ENTITY	Critical function of RA-GEF-2 / Rapgef6 , a guanine_nucleotide exchange factor for Rap1 , in mouse spermatogenesis .
9570294	8	guanine_nucleotide	1398,1416	Rap1	1438,1442	guanine nucleotide	Rap1	CHEBI:61292	5906	Chemical	Gene	protein|amod|START_ENTITY protein|nmod|family family|amod|END_ENTITY	Recent studies have also identified a novel signaling pathway initiated by the interaction of mammalian Cbl proteins with the SH2 domains of Crk adaptor molecules , which results in Cbl 's linkage with C3G , a guanine_nucleotide exchange protein for Rap1 family of small G-proteins .
12370312	0	guanine_nucleotide	22,40	Rap1_GTPase	61,72	guanine nucleotide	Rap1 GTPase	CHEBI:61292	38244(Tax:7227)	Chemical	Gene	factor|amod|START_ENTITY factor|nmod|END_ENTITY	Drosophila PDZ-GEF , a guanine_nucleotide exchange factor for Rap1_GTPase , reveals a novel upstream regulatory mechanism in the mitogen-activated protein kinase signaling pathway .
9032266	0	guanine_nucleotide	50,68	Ras-GRF2	32,40	guanine nucleotide	Ras-GRF2	CHEBI:61292	19418(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Cloning Cloning|nmod|END_ENTITY	Cloning and characterization of Ras-GRF2 , a novel guanine_nucleotide exchange factor for Ras .
21073870	0	guanine_nucleotide	28,46	Ras2	23,27	guanine nucleotide	Ras2	CHEBI:61292	855625(Tax:4932)	Chemical	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Feedback regulation of Ras2 guanine_nucleotide exchange factor -LRB- Ras2-GEF -RRB- activity of Cdc25p by Cdc25p phosphorylation in the yeast Saccharomyces_cerevisiae .
18692051	0	guanine_nucleotide	65,83	Rheb	104,108	guanine nucleotide	Rheb	CHEBI:61292	6009	Chemical	Gene	factor|amod|START_ENTITY factor|nmod|END_ENTITY	Biochemical characterisation of TCTP questions its function as a guanine_nucleotide exchange factor for Rheb .
24255780	0	guanine_nucleotide	31,49	Rho	27,30	guanine nucleotide	Rho	CHEBI:61292	6010	Chemical	Gene	inhibitor|compound|START_ENTITY inhibitor|compound|END_ENTITY	Lentivirus vector-mediated Rho guanine_nucleotide dissociation inhibitor 2 overexpression induces beta-2_adrenergic_receptor desensitization in airway smooth muscle cells .
11113201	0	guanine_nucleotide	98,116	Rho1	137,141	guanine nucleotide	Rho1	CHEBI:61292	856294(Tax:4932)	Chemical	Gene	factor|amod|START_ENTITY factor|nmod|END_ENTITY	Wsc1 and Mid2 are cell surface sensors for cell wall integrity signaling that act through Rom2 , a guanine_nucleotide exchange factor for Rho1 .
12221096	0	guanine_nucleotide	8,26	RhoA	47,51	guanine nucleotide	RhoA	CHEBI:61292	387	Chemical	Gene	factor|amod|START_ENTITY factor|nmod|END_ENTITY	XPLN , a guanine_nucleotide exchange factor for RhoA and RhoB , but not RhoC .
14512443	0	guanine_nucleotide	53,71	RhoA	92,96	guanine nucleotide	RhoA	CHEBI:61292	387	Chemical	Gene	factor|amod|START_ENTITY factor|nmod|END_ENTITY	G Protein betagamma subunits stimulate p114RhoGEF , a guanine_nucleotide exchange factor for RhoA and Rac1 : regulation of cell shape and reactive oxygen species production .
15455375	0	guanine_nucleotide	24,42	RhoA	63,67	guanine nucleotide	RhoA	CHEBI:61292	387	Chemical	Gene	factor|amod|START_ENTITY factor|nmod|END_ENTITY	Activation of gef-h1 , a guanine_nucleotide exchange factor for RhoA , by DNA transfection .
18477585	0	guanine_nucleotide	4,22	Sec2	40,44	guanine nucleotide	Sec2	CHEBI:61292	2524	Chemical	Gene	factors|amod|START_ENTITY factors|amod|END_ENTITY	The guanine_nucleotide exchange factors Sec2 and PRONE : candidate synapomorphies for the Opisthokonta and the Archaeplastida .
12045183	0	guanine_nucleotide	25,43	Sec4p	19,24	guanine nucleotide	Sec4p	CHEBI:61292	850543(Tax:4932)	Chemical	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	Ypt32 recruits the Sec4p guanine_nucleotide exchange factor , Sec2p , to secretory vesicles ; evidence for a Rab cascade in yeast .
9476900	0	guanine_nucleotide	17,35	Sec7	52,56	guanine nucleotide	Sec7	CHEBI:61292	9267	Chemical	Gene	domain|amod|START_ENTITY domain|compound|END_ENTITY	Structure of the guanine_nucleotide exchange factor Sec7 domain of human arno and analysis of the interaction with ARF GTPase .
12370828	0	guanine_nucleotide	37,55	Sos1	32,36	guanine nucleotide	Sos1	CHEBI:61292	313845(Tax:10116)	Chemical	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	Light Chain 3 associates with a Sos1 guanine_nucleotide exchange factor : its significance in the Sos1-mediated Rac1 signaling leading to membrane ruffling .
11130063	0	guanine_nucleotide	46,64	Tiam1	84,89	guanine nucleotide	Tiam1	CHEBI:61292	7074	Chemical	Gene	region|amod|START_ENTITY region|nmod|END_ENTITY	Crystal structure of Rac1 in complex with the guanine_nucleotide exchange region of Tiam1 .
16546099	0	guanine_nucleotide	21,39	Vav	17,20	guanine nucleotide	Vav	CHEBI:61292	22324(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Requirements Requirements|nmod|END_ENTITY	Requirements for Vav guanine_nucleotide exchange factors and Rho GTPases in FcgammaR - and complement-mediated phagocytosis .
21865158	0	guanine_nucleotide	12,30	Vav	0,3	guanine nucleotide	Vav	CHEBI:61292	22324(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|protein protein|compound|END_ENTITY	Vav protein guanine_nucleotide exchange factor regulates CD36 protein-mediated macrophage foam cell formation via calcium and dynamin-dependent processes .
7516472	0	guanine_nucleotide	26,44	Vav	22,25	guanine nucleotide	Vav	CHEBI:61292	7409	Chemical	Gene	START_ENTITY|nsubj|stimulation stimulation|nmod|END_ENTITY	Direct stimulation of Vav guanine_nucleotide exchange activity for Ras by phorbol_esters and diglycerides .
8289830	0	guanine_nucleotide	64,82	Vav	60,63	guanine nucleotide	Vav	CHEBI:61292	22324(Tax:10090)	Chemical	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Activation of Ras in vitro and in intact fibroblasts by the Vav guanine_nucleotide exchange protein .
8484124	0	guanine_nucleotide	27,45	Vav	67,70	guanine nucleotide	Vav	CHEBI:61292	7409	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Tyrosine_kinase-stimulated guanine_nucleotide exchange activity of Vav in T cell activation .
17060455	0	guanine_nucleotide	79,97	Vav1	74,78	guanine nucleotide	Vav1	CHEBI:61292	7409	Chemical	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	The Rac effector p67phox regulates phagocyte NADPH oxidase by stimulating Vav1 guanine_nucleotide exchange activity .
16384856	0	guanine_nucleotide	19,37	Vav3	0,4	guanine nucleotide	Vav3	CHEBI:61292	10451	Chemical	Gene	factor|compound|START_ENTITY END_ENTITY|appos|factor	Vav3 , a Rho GTPase guanine_nucleotide exchange factor , increases during progression to androgen independence in prostate_cancer cells and potentiates androgen_receptor transcriptional activity .
12270917	0	guanine_nucleotide	23,41	alpha-catenin-related_protein	63,92	guanine nucleotide	alpha-catenin-related protein	CHEBI:61292	8727	Chemical	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Association of Lbc Rho guanine_nucleotide exchange factor with alpha-catenin-related_protein , alpha-catulin/CTNNAL1 , supports serum response factor activation .
3140235	0	guanine_nucleotide	37,55	beta-subunit	75,87	guanine nucleotide	beta-subunit	CHEBI:61292	32554(Tax:7227)	Chemical	Gene	START_ENTITY|dobj|gene gene|compound|END_ENTITY	Cloning of a Drosophila_melanogaster guanine_nucleotide regulatory protein beta-subunit gene and characterization of its expression during development .
12626503	0	guanine_nucleotide	116,134	beta_PIX	107,115	guanine nucleotide	beta PIX	CHEBI:61292	8874	Chemical	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the beta_PIX guanine_nucleotide exchange factor for Rac1 and Cdc42 .
11839748	0	guanine_nucleotide	38,56	clg	14,17	guanine nucleotide	clg	CHEBI:61292	101497(Tax:10090)	Chemical	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	Activation of clg , a novel dbl family guanine_nucleotide exchange factor gene , by proviral insertion at evi24 , a common integration site in B cell and myeloid_leukemias .
14623968	0	guanine_nucleotide	51,69	eEF1A	130,135	guanine nucleotide	eEF1A	CHEBI:61292	1915	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|nmod|END_ENTITY	Translationally_controlled_tumor_protein acts as a guanine_nucleotide dissociation inhibitor on the translation elongation factor eEF1A .
8520487	0	guanine_nucleotide	39,57	eIF-2B	97,103	guanine nucleotide	eIF-2B	CHEBI:61292	8893	Chemical	Gene	subunits|compound|START_ENTITY subunits|amod|END_ENTITY	Multidomain organization of eukaryotic guanine_nucleotide exchange translation initiation factor eIF-2B subunits revealed by analysis of conserved sequence motifs .
172495	1	guanine_nucleotide	87,105	elongation_factor_G	122,141	guanine nucleotide	elongation factor G	CHEBI:61292	85476	Chemical	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Assignment of guanine_nucleotide binding site to elongation_factor_G .
8430087	0	guanine_nucleotide	23,41	gamma_2	61,68	guanine nucleotide	gamma 2	CHEBI:61292	7453	Chemical	Gene	subunits|amod|START_ENTITY subunits|amod|END_ENTITY	Prenyl modification of guanine_nucleotide regulatory protein gamma_2 subunits is not required for interaction with the transducin alpha subunit or rhodopsin .
10208427	0	guanine_nucleotide	80,98	hSos1	120,125	guanine nucleotide	hSos1	CHEBI:61292	6654	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Isoform-specific insertion near the Grb2-binding domain modulates the intrinsic guanine_nucleotide exchange activity of hSos1 .
21048939	0	guanine_nucleotide	27,45	leucine-rich_repeat_kinase_2	66,94	guanine nucleotide	leucine-rich repeat kinase 2	CHEBI:61292	120892	Chemical	Gene	factor|amod|START_ENTITY factor|nmod|END_ENTITY	ARHGEF7 _ -LRB- Beta-PIX -RRB- acts as guanine_nucleotide exchange factor for leucine-rich_repeat_kinase_2 .
21064165	0	guanine_nucleotide	60,78	p115-RhoGEF	100,111	guanine nucleotide	p115-RhoGEF	CHEBI:61292	9138	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Modulation of a GEF switch : autoinhibition of the intrinsic guanine_nucleotide exchange activity of p115-RhoGEF .
9641916	0	guanine_nucleotide	26,44	p115_RhoGEF	66,77	guanine nucleotide	p115 RhoGEF	CHEBI:61292	9138;9181	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Direct stimulation of the guanine_nucleotide exchange activity of p115_RhoGEF by Galpha13 .
1674518	0	guanine_nucleotide	39,57	p21ras	75,81	guanine nucleotide	p21ras	CHEBI:61292	3265	Chemical	Gene	binding|amod|START_ENTITY END_ENTITY|amod|binding	CD2 antigen mediated activation of the guanine_nucleotide binding proteins p21ras in human T lymphocytes .
16954223	0	guanine_nucleotide	77,95	smgGDS	70,76	guanine nucleotide	smgGDS	CHEBI:61292	5910	Chemical	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	betaPak-interacting_exchange_factor-mediated Rac1 activation requires smgGDS guanine_nucleotide exchange factor in basic_fibroblast_growth_factor-induced neurite outgrowth .
2166281	0	guanine_nucleotide	24,42	vasoactive_intestinal_peptide	67,96	guanine nucleotide	vasoactive intestinal peptide	CHEBI:61292	117064(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|nmod|END_ENTITY	Direct demonstration of guanine_nucleotide sensitive receptors for vasoactive_intestinal_peptide in the anterior lobe of the rat pituitary gland .
11485305	0	guanine_nucleotides	33,52	CCR5	25,29	guanine nucleotides	CCR5	MESH:D006150	1234	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Allosteric regulation of CCR5 by guanine_nucleotides and HIV-1 envelope .
6244163	1	guanine_nucleotides	113,132	EF-2	136,140	guanine nucleotides	EF-2	MESH:D006150	29565(Tax:10116)	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of periodate-oxidized guanine_nucleotides to EF-2 .
1503566	0	guanine_nucleotides	30,49	EF-Tu	59,64	guanine nucleotides	EF-Tu	MESH:D006150	7284	Chemical	Gene	START_ENTITY|acl|bound bound|nmod|END_ENTITY	Rate laws for the exchange of guanine_nucleotides bound to EF-Tu catalysed by EF-Ts .
1804111	0	guanine_nucleotides	53,72	EF-Tu	82,87	guanine nucleotides	EF-Tu	MESH:D006150	7284	Chemical	Gene	START_ENTITY|acl|bound bound|nmod|END_ENTITY	Analysis of rate constants governing the exchange of guanine_nucleotides bound to EF-Tu catalysed by EF-Ts .
2996970	0	guanine_nucleotides	76,95	VIP	0,3	guanine nucleotides	VIP	MESH:D006150	117064(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|dep|effect	VIP binding to epithelial cell membranes of rat ventral prostate : effect of guanine_nucleotides .
2157494	0	guanine_nucleotides	30,49	elongation_factor_2	64,83	guanine nucleotides	elongation factor 2	MESH:D006150	29565(Tax:10116)	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of periodate-oxidized guanine_nucleotides to eukaryotic elongation_factor_2 .
6244163	0	guanine_nucleotides	48,67	elongation_factor_2	16,35	guanine nucleotides	elongation factor 2	MESH:D006150	29565(Tax:10116)	Chemical	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of elongation_factor_2 -LRB- EF-2 -RRB- with guanine_nucleotides and ribosomes .
2995942	0	guanine_nucleotides	11,30	enkephalin	69,79	guanine nucleotides	enkephalin	MESH:D006150	29237(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|receptors receptors|compound|END_ENTITY	Effects of guanine_nucleotides , transition_metals and temperature on enkephalin receptors of rat brain membranes .
11108807	0	guanine_phosphonomethoxyalkyl	15,44	GMP_kinase	62,72	guanine phosphonomethoxyalkyl	GMP kinase	null	14923(Tax:10090)	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Interaction of guanine_phosphonomethoxyalkyl derivatives with GMP_kinase isoenzymes .
9629791	0	guanine_phosphoribosyl	58,80	HPRT	94,98	guanine phosphoribosyl	HPRT	null	3251	Chemical	Gene	deficiency|amod|START_ENTITY deficiency|appos|END_ENTITY	-LSB- Biochemical , enzymatic and genetic study of hypoxanthine guanine_phosphoribosyl transferase -LRB- HPRT -RRB- deficiency -RSB- .
9188527	0	guanosine	18,27	Ran	14,17	guanosine	Ran	MESH:D006151	100189578(Tax:8355)	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of Ran guanosine triphosphatase-dependent nuclear transport by the matrix protein of vesicular_stomatitis virus .
16365460	0	guanosine	104,113	Vav	100,103	guanosine	Vav	MESH:D006151	7409	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Azathioprine suppresses ezrin-radixin-moesin-dependent T cell-APC conjugation through inhibition of Vav guanosine exchange activity on Rac proteins .
1652115	0	guanosine_cyclic_monophosphate	51,81	angiotensin_II	83,97	guanosine cyclic monophosphate	angiotensin II	MESH:D006152	183	Chemical	Gene	prostaglandin_E2|dep|START_ENTITY prostaglandin_E2|dep|END_ENTITY	Effect of frusemide on atrial natriuretic peptide , guanosine_cyclic_monophosphate , angiotensin_II , aldosterone , vasopressin , prostaglandin_E2 and blood volume in the nephrotic_syndrome .
1652115	0	guanosine_cyclic_monophosphate	51,81	vasopressin	112,123	guanosine cyclic monophosphate	vasopressin	MESH:D006152	551	Chemical	Gene	prostaglandin_E2|dep|START_ENTITY prostaglandin_E2|dep|END_ENTITY	Effect of frusemide on atrial natriuretic peptide , guanosine_cyclic_monophosphate , angiotensin_II , aldosterone , vasopressin , prostaglandin_E2 and blood volume in the nephrotic_syndrome .
15784708	0	guanosine_monophosphate	89,112	corticotropin-releasing_hormone	124,155	guanosine monophosphate	corticotropin-releasing hormone	MESH:D006157	1392	Chemical	Gene	pathway|compound|START_ENTITY pathway|nmod|END_ENTITY	Preeclampsia is associated with impaired regulation of the placental nitric_oxide-cyclic guanosine_monophosphate pathway by corticotropin-releasing_hormone -LRB- CRH -RRB- and CRH-related peptides .
12781179	0	guanosine_nucleoside	66,86	S-adenosyl-L-homocysteine_hydrolase	25,60	guanosine nucleoside	S-adenosyl-L-homocysteine hydrolase	null	191	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Unexpected inhibition of S-adenosyl-L-homocysteine_hydrolase by a guanosine_nucleoside .
1112784	0	guanosine_nucleotides	15,36	elongation_factor_2	42,61	guanosine nucleotides	elongation factor 2	null	29565(Tax:10116)	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of guanosine_nucleotides with elongation_factor_2 .
1112785	0	guanosine_nucleotides	15,36	elongation_factor_2	42,61	guanosine nucleotides	elongation factor 2	null	1938	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of guanosine_nucleotides with elongation_factor_2 .
3593238	0	guanosine_triphosphate	10,32	Ca2	62,65	guanosine triphosphate	Ca2	MESH:D006160	760	Chemical	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	Effect of guanosine_triphosphate on the release and uptake of Ca2 + in saponin-permeabilized macrophages and the skeletal-muscle sarcoplasmic reticulum .
3662529	0	guanosine_triphosphate	10,32	Ca2	51,54	guanosine triphosphate	Ca2	MESH:D006160	760	Chemical	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	Effect of guanosine_triphosphate on the release of Ca2 + from intracellular store sites of saponin-treated human peripheral lymphocytes .
6308053	8	guanosine_triphosphate	1203,1225	PTE	1185,1188	guanosine triphosphate	PTH	MESH:D006160	5741	Chemical	Gene	infusion|nmod|START_ENTITY infusion|compound|END_ENTITY	Pretreatment of the membranes made after PTE infusion with guanosine_triphosphate -LRB- GTP -RRB- , which is known to produce dissociation of receptor-bound PTH , failed to restore either receptor number or PTH-stimulated adenylate cyclase .
7566515	0	guanyl_nucleotides	11,29	CCKB	33,37	guanyl nucleotides	CCKB	null	887	Chemical	Gene	START_ENTITY|nmod|binding binding|compound|END_ENTITY	Effects of guanyl_nucleotides on CCKB receptor binding in brain tissue and continuous cell lines : a comparative study .
7603625	0	guanyl_nucleotides	68,86	gamma-Hydroxybutyrate_receptor	0,30	guanyl nucleotides	gamma-Hydroxybutyrate receptor	null	306771(Tax:10116)	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|END_ENTITY	gamma-Hydroxybutyrate_receptor binding in rat brain is inhibited by guanyl_nucleotides and pertussis toxin .
6111927	0	guanylate	26,35	Angiotensin_II	0,14	guanylate	Angiotensin II	null	24179(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates guanylate cyclase activity in aorta , heart , and kidney .
22846999	0	guanylate	37,46	CaVb	64,68	guanylate	CaVb	null	11238	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	A quartet of leucine residues in the guanylate kinase domain of CaVb determines the plasma membrane density of the CaV2 .3 channel .
17220895	0	guanylate	4,13	PSD-95	41,47	guanylate	PSD-95	null	1742	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	The guanylate kinase domain of the MAGUK PSD-95 binds dynamically to a conserved motif in MAP1a .
21270629	0	guanylate	131,140	Toll-like_receptor_4	0,20	guanylate	Toll-like receptor 4	null	21898(Tax:10090)	Chemical	Gene	mechanisms|amod|START_ENTITY ischemic_injury|nmod|mechanisms confers|nmod|ischemic_injury confers|nsubj|signaling signaling|compound|END_ENTITY	Toll-like_receptor_4 signaling confers cardiac protection against ischemic_injury via inducible nitric_oxide synthase - and soluble guanylate cyclase-dependent mechanisms .
16410224	0	guanylate	34,43	VEGF	151,155	guanylate	VEGF	null	7422	Chemical	Gene	cyclase|compound|START_ENTITY cyclase|appos|END_ENTITY	Endostatin down-regulates soluble guanylate cyclase -LRB- sGC -RRB- in endothelial cells in vivo : influence of endostatin on vascular_endothelial_growth_factor -LRB- VEGF -RRB- signaling .
1675590	0	guanylate	40,49	atrial_natriuretic_factor	72,97	guanylate	atrial natriuretic factor	null	24602(Tax:10116)	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Calcium reveals different mechanisms of guanylate cyclase activation by atrial_natriuretic_factor and ATP in rat lung membranes .
1971707	0	guanylate	14,23	atrial_natriuretic_factor	44,69	guanylate	atrial natriuretic factor	null	4878	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Regulation of guanylate cyclase activity by atrial_natriuretic_factor and protein kinase C .
2884994	0	guanylate	59,68	atrial_natriuretic_factor	19,44	guanylate	atrial natriuretic factor	null	24602(Tax:10116)	Chemical	Gene	receptor|nmod|START_ENTITY receptor|compound|END_ENTITY	Association of the atrial_natriuretic_factor receptor with guanylate cyclase in solubilized rat glomerular membranes .
27037373	0	guanylate	103,112	heme	71,75	guanylate	heme	null	100307951(Tax:9913)	Chemical	Gene	depletion|compound|START_ENTITY depletion|amod|END_ENTITY	Potential role of mitochondrial superoxide decreasing ferrochelatase _ heme in coronary artery soluble guanylate cyclase depletion by Angiotensin_II .
23248289	0	guanylate	7,16	mGBP2	36,41	guanylate	mGBP2	null	14469(Tax:10090)	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Murine guanylate binding protein 2 -LRB- mGBP2 -RRB- controls Toxoplasma_gondii replication .
15005606	0	guanylate	178,187	neurocalcin_delta	79,96	guanylate	neurocalcin delta	null	83988	Chemical	Gene	START_ENTITY|nsubj|characterization characterization|nmod|END_ENTITY	Structural , biochemical , and functional characterization of the calcium sensor neurocalcin_delta in the inner retinal neurons and its linkage with the rod outer segment membrane guanylate cyclase transduction system .
8824805	0	guanylate	92,101	p55	53,56	guanylate	p55	null	4354	Chemical	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Complete genomic organization of the human erythroid p55 gene -LRB- MPP1 -RRB- , a membrane-associated guanylate kinase homologue .
2580527	0	guanylate	54,63	substance_P	17,28	guanylate	substance P	null	6863	Chemical	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Cation-dependent substance_P activation of the enzyme guanylate cyclase .
8140274	0	guanylyl	68,76	ANF	92,95	guanylyl	ANF	null	24602(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Cardiovascular and renal functional effects of an antagonist of the guanylyl cyclase-linked ANF receptor .
14993224	0	guanylyl	99,107	RetGC	117,122	guanylyl	RetGC	null	3000	Chemical	Gene	regulation|amod|START_ENTITY regulation|appos|END_ENTITY	Guanylyl cyclase-activating proteins -LRB- GCAPs -RRB- are Ca2 + / Mg2 + sensors : implications for photoreceptor guanylyl cyclase -LRB- RetGC -RRB- regulation in mammalian photoreceptors .
20195240	0	guggulsterone	6,19	NF-kappaB	46,55	guggulsterone	NF-kappaB	MESH:C023617	18033(Tax:10090)	Chemical	Gene	GG-52|amod|START_ENTITY inhibits|nsubj|GG-52 inhibits|dobj|signaling signaling|compound|END_ENTITY	Novel guggulsterone derivative GG-52 inhibits NF-kappaB signaling in intestinal epithelial cells and attenuates acute murine colitis .
10999436	0	gypenoside	22,32	CCl4	81,85	gypenoside	CCl4	MESH:C474918	116637(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY induced|nsubj|effect induced|nmod|END_ENTITY	Therapeutic effect of gypenoside on chronic liver_injury and fibrosis induced by CCl4 in rats .
18617524	4	h2-calponin	396,407	Cnn2	414,418	h2-calponin	Cnn2	null	12798(Tax:10090)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	To study the functional significance , h2-calponin gene -LRB- Cnn2 -RRB- interrupted mice were constructed .
9560321	0	haematin	59,67	macrophage-migration-inhibitory_factor	15,53	haematin	macrophage-migration-inhibitory factor	CHEBI:36161	4282	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of macrophage-migration-inhibitory_factor with haematin .
15755286	0	haematogones	34,46	CD43	15,19	haematogones	CD43	null	6693	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Characterizing CD43 expression in haematogones using multicolor flow cytometric analysis .
3243342	0	haemoglobin	20,31	growth_hormone	42,56	haemoglobin	growth hormone	CHEBI:35143	2688	Chemical	Gene	levels|compound|START_ENTITY levels|nmod|secretion secretion|amod|END_ENTITY	Effect of increased haemoglobin levels on growth_hormone -LRB- GH -RRB- secretion in beta-thalassaemia major : differences between prepubertal subjects and patients with delayed puberty .
194641	0	halide	23,29	Myeloperoxidase	0,15	halide	Myeloperoxidase	CHEBI:37578	4353	Chemical	Gene	system|amod|START_ENTITY END_ENTITY|dep|system	Myeloperoxidase -- H2O2 -- halide system : cytotoxic effect on human blood leukocytes .
6255998	0	halide	4,10	myeloperoxidase	24,39	halide	myeloperoxidase	CHEBI:37578	4353	Chemical	Gene	complexes|amod|START_ENTITY complexes|nmod|END_ENTITY	The halide complexes of myeloperoxidase and the mechanism of the halogenation reactions .
22886133	0	halide	35,41	polyphenol_oxidase	56,74	halide	polyphenol oxidase	CHEBI:37578	5498	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Substrate inhibition competes with halide inhibition in polyphenol_oxidase .
23471296	0	halides	22,29	TRPM7	0,5	halides	TRPM7	CHEBI:46714	54822	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	TRPM7 is regulated by halides through its kinase domain .
23471296	0	halides	22,29	TRPM7	0,5	halides	TRPM7	CHEBI:46714	54822	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	TRPM7 is regulated by halides through its kinase domain .
12269834	0	halides	44,51	lactoperoxidase	12,27	halides	lactoperoxidase	CHEBI:46714	4025	Chemical	Gene	compound|nmod|START_ENTITY compound|nsubj|Reaction Reaction|nmod|END_ENTITY	Reaction of lactoperoxidase compound I with halides and thiocyanate .
11361012	0	haloamines	72,82	semicarbazide-sensitive_amine_oxidase	27,64	haloamines	semicarbazide-sensitive amine oxidase	null	314	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of tissue-bound semicarbazide-sensitive_amine_oxidase by two haloamines , 2-bromoethylamine and 3-bromopropylamine .
26664138	0	halofuginone	35,47	TGF-b	14,19	halofuginone	TGF-b	MESH:C010176	21803(Tax:10090)	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Inhibition of TGF-b signaling with halofuginone can enhance the antitumor effect of irradiation in Lewis_lung_cancer .
17180598	0	halofuginone	68,80	TGF-beta	84,92	halofuginone	TGF-beta	MESH:C010176	7040	Chemical	Gene	START_ENTITY|nmod|signaling signaling|compound|END_ENTITY	Gene expression during chemically induced liver fibrosis : effect of halofuginone on TGF-beta signaling .
23480137	0	halofuginone	106,118	TGFb	10,14	halofuginone	TGFb	MESH:C010176	7040	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|dep|effect	Targeting TGFb signaling to inhibit fibroblast activation as a therapy for fibrosis and cancer : effect of halofuginone .
12482197	0	halofuginone	10,22	TSK	57,60	halofuginone	TSK	MESH:C010176	14118(Tax:10090)	Chemical	Gene	_|amod|START_ENTITY _|appos|END_ENTITY	Effect of halofuginone on the development of tight_skin _ -LRB- TSK -RRB- _ syndrome .
12482197	0	halofuginone	10,22	tight_skin	45,55	halofuginone	tight skin	MESH:C010176	14118(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|development development|nmod|END_ENTITY	Effect of halofuginone on the development of tight_skin _ -LRB- TSK -RRB- _ syndrome .
15997102	0	halogenated_anilines	43,63	cytochrome_P450_2E1	20,39	halogenated anilines	cytochrome P450 2E1	null	1571	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of human cytochrome_P450_2E1 by halogenated_anilines , phenols , and thiophenols .
18953099	0	halogenated_biphenyl	6,26	CYP1A1	44,50	halogenated biphenyl	CYP1A1	null	1543	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	A low halogenated_biphenyl -LRB- PCB3 -RRB- increases CYP1A1 expression and activity via the estrogen receptor beta in the porcine ovary .
6435605	0	halogenated_biphenyls	48,69	uroporphyrinogen_decarboxylase	14,44	halogenated biphenyls	uroporphyrinogen decarboxylase	null	424590(Tax:9031)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of uroporphyrinogen_decarboxylase by halogenated_biphenyls in chick hepatocyte cultures .
21514152	0	halogenated_phenylcoumarins	4,31	tyrosinase	35,45	halogenated phenylcoumarins	tyrosinase	null	7299	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	New halogenated_phenylcoumarins as tyrosinase inhibitors .
22001566	0	halogenated_pregnanes	13,34	CYP17A1	79,86	halogenated pregnanes	CYP17A1	null	1586	Chemical	Gene	Synthesis|nmod|START_ENTITY Synthesis|nmod|END_ENTITY	Synthesis of halogenated_pregnanes , mechanistic probes of steroid hydroxylases CYP17A1 and CYP21A2 .
16885370	0	halogenated_pyrimidines	51,74	MED1	22,26	halogenated pyrimidines	MED1	null	19014(Tax:10090)	Chemical	Gene	exhibits|nmod|START_ENTITY exhibits|nsubj|END_ENTITY	The DNA N-glycosylase MED1 exhibits preference for halogenated_pyrimidines and is involved in the cytotoxicity of 5-iododeoxyuridine .
8847965	0	haloperidol	29,40	CYP3A	59,64	haloperidol	CYP3A	MESH:D006220	170509(Tax:10116)	Chemical	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Studies on the metabolism of haloperidol -LRB- HP -RRB- : the role of CYP3A in the production of the neurotoxic pyridinium metabolite HPP + found in rat brain following ip administration of HP .
10211916	0	haloperidol	185,196	CYP3A4	174,180	haloperidol	CYP3A4	MESH:D006220	1576	Chemical	Gene	metabolism|amod|START_ENTITY Effects|nmod|metabolism Effects|nmod|END_ENTITY	Effects of itraconazole on the steady-state plasma concentrations of haloperidol and its reduced metabolite in schizophrenic patients : in vivo evidence of the involvement of CYP3A4 for haloperidol metabolism .
10211916	0	haloperidol	69,80	CYP3A4	174,180	haloperidol	CYP3A4	MESH:D006220	1576	Chemical	Gene	concentrations|nmod|START_ENTITY Effects|nmod|concentrations Effects|nmod|END_ENTITY	Effects of itraconazole on the steady-state plasma concentrations of haloperidol and its reduced metabolite in schizophrenic patients : in vivo evidence of the involvement of CYP3A4 for haloperidol metabolism .
12433827	0	haloperidol	14,25	CYP3A4	42,48	haloperidol	CYP3A4	MESH:D006220	1576	Chemical	Gene	START_ENTITY|nmod|modifiers modifiers|nmod|END_ENTITY	Quinidine and haloperidol as modifiers of CYP3A4 activity : multisite kinetic model approach .
12584149	0	haloperidol	98,109	CYP3A4	35,41	haloperidol	CYP3A4	MESH:D006220	1576	Chemical	Gene	metabolism|nmod|START_ENTITY Assessment|nmod|metabolism Assessment|nmod|contributions contributions|nmod|END_ENTITY	Assessment of the contributions of CYP3A4 and CYP3A5 in the metabolism of the antipsychotic agent haloperidol to its potentially neurotoxic pyridinium metabolite and effect of antidepressants on the bioactivation pathway .
9140699	0	haloperidol	54,65	CYP3A4	15,21	haloperidol	CYP3A4	MESH:D006220	1576	Chemical	Gene	metabolism|nmod|START_ENTITY Involvement|nmod|metabolism Involvement|nmod|END_ENTITY	Involvement of CYP3A4 and CYP2D6 in the metabolism of haloperidol .
10332800	0	haloperidol	38,49	Fos	63,66	haloperidol	Fos	MESH:D006220	314322(Tax:10116)	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|protein protein|compound|END_ENTITY	NMDA receptor blockade attenuates the haloperidol induction of Fos protein in the dorsal but not the ventral striatum .
11106001	0	haloperidol	116,127	Fos	70,73	haloperidol	Fos	MESH:D006220	314322(Tax:10116)	Chemical	Gene	comparison|nmod|START_ENTITY effect|dep|comparison effect|nmod|mosapramine mosapramine|nmod|expression expression|nmod|protein protein|compound|END_ENTITY	The effect of the antipsychotic drug mosapramine on the expression of Fos protein in the rat brain : comparison with haloperidol , clozapine and risperidone .
14663205	0	haloperidol	11,22	Fos	40,43	haloperidol	Fos	MESH:D006220	2353	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of haloperidol and clozapine on Fos expression in the primate striatum .
15140647	0	haloperidol	124,135	Fos	77,80	haloperidol	Fos	MESH:D006220	14281(Tax:10090)	Chemical	Gene	administration|nmod|START_ENTITY subtypes|nmod|administration subtypes|nmod|induction induction|nmod|catalepsy catalepsy|nmod|expression expression|compound|END_ENTITY	Role of NMDA receptor subtypes in the induction of catalepsy and increase in Fos protein expression after administration of haloperidol .
8750842	0	haloperidol	67,78	Fos	0,3	haloperidol	Fos	MESH:D006220	14281(Tax:10090)	Chemical	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	Fos is not involved in the regulation of the proenkephalin gene by haloperidol in the mouse striatum .
9681590	0	haloperidol	54,65	Fos	25,28	haloperidol	Fos	MESH:D006220	314322(Tax:10116)	Chemical	Gene	administration|amod|START_ENTITY induced|nmod|administration induced|nsubj|expression expression|nmod|protein protein|compound|END_ENTITY	Widespread expression of Fos protein induced by acute haloperidol administration in the rat brain .
9721035	0	haloperidol	77,88	Fos	19,22	haloperidol	Fos	MESH:D006220	314322(Tax:10116)	Chemical	Gene	cross-tolerance|nmod|START_ENTITY expression|dep|cross-tolerance expression|compound|END_ENTITY	Olanzapine-induced Fos expression in the rat forebrain ; cross-tolerance with haloperidol and clozapine .
7637876	0	haloperidol	84,95	Glutamate_decarboxylase	0,23	haloperidol	Glutamate decarboxylase	MESH:D006220	24957(Tax:10116)	Chemical	Gene	treatments|amod|START_ENTITY effects|nmod|treatments comparison|nmod|effects RNA|dep|comparison RNA|compound|END_ENTITY	Glutamate_decarboxylase messenger RNA in rat pallidum : comparison of the effects of haloperidol , clozapine and combined haloperidol-scopolamine treatments .
9399630	0	haloperidol	14,25	HPTP	99,103	haloperidol	HPTP	MESH:D006220	5789	Chemical	Gene	Metabolism|nmod|START_ENTITY END_ENTITY|nsubj|Metabolism	Metabolism of haloperidol to pyridinium species in patients receiving high doses intravenously : is HPTP an intermediate ?
11602683	0	haloperidol	127,138	Neurotensin	0,11	haloperidol	Neurotensin	MESH:D006220	299757(Tax:10116)	Chemical	Gene	administration|amod|START_ENTITY sensitivity|nmod|administration sensitivity|nsubj|levels levels|compound|END_ENTITY	Neurotensin levels in specific brain regions and hypnotic sensitivity to ethanol and pentobarbital as a function of time after haloperidol administration in selectively bred rat lines .
11907174	0	haloperidol	24,35	PKA	196,199	haloperidol	PKA	MESH:D006220	25636(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Differential effects of haloperidol and clozapine on -LSB- -LRB- 3 -RRB- H -RSB- cAMP binding , protein_kinase_A -LRB- PKA -RRB- activity , and mRNA and protein expression of selective regulatory and catalytic subunit isoforms of PKA in rat brain .
11175925	0	haloperidol	35,46	Prolactin	0,9	haloperidol	Prolactin	MESH:D006220	5617	Chemical	Gene	challenge|amod|START_ENTITY secretion|nmod|challenge secretion|nsubj|END_ENTITY	Prolactin secretion in response to haloperidol challenge in delusional -LRB- psychotic -RRB- and non-delusional_depression .
18359173	0	haloperidol	83,94	Prolactin	0,9	haloperidol	Prolactin	MESH:D006220	280901(Tax:9913)	Chemical	Gene	response|nmod|START_ENTITY secretion|dep|response secretion|compound|END_ENTITY	Prolactin secretion after hypothalamic deafferentation in beef calves : response to haloperidol , alpha-methyl-rho-tyrosine , thyrotropin-releasing_hormone and ovariectomy .
2018629	0	haloperidol	23,34	Prolactin	0,9	haloperidol	Prolactin	MESH:D006220	5617	Chemical	Gene	responses|xcomp|START_ENTITY responses|nsubj|END_ENTITY	Prolactin responses to haloperidol in drug-free and treated schizophrenic patients .
2255750	0	haloperidol	31,42	Prolactin	0,9	haloperidol	Prolactin	MESH:D006220	5617	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Prolactin response to low-dose haloperidol challenge in schizophrenic , non-schizophrenic_psychotic , and control subjects .
3237947	0	haloperidol	23,34	Prolactin	0,9	haloperidol	Prolactin	MESH:D006220	5617	Chemical	Gene	responses|xcomp|START_ENTITY responses|nsubj|END_ENTITY	Prolactin responses to haloperidol in normal young women .
6584932	0	haloperidol	51,62	Prolactin	0,9	haloperidol	Prolactin	MESH:D006220	5617	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Prolactin response to single and multiple doses of haloperidol in schizophrenic patients .
8915564	0	haloperidol	24,35	Prolactin	0,9	haloperidol	Prolactin	MESH:D006220	5617	Chemical	Gene	treatment|amod|START_ENTITY monitoring|nmod|treatment monitoring|compound|END_ENTITY	Prolactin monitoring of haloperidol and pimozide treatment in children with Tourette 's _ syndrome .
9542792	0	haloperidol	92,103	Prolactin	0,9	haloperidol	Prolactin	MESH:D006220	5617	Chemical	Gene	test|xcomp|START_ENTITY test|nsubj|response response|compound|END_ENTITY	Prolactin response to D-fenfluramine challenge test as a predictor of treatment response to haloperidol in acute schizophrenia .
11409749	0	haloperidol	37,48	RGS2	24,28	haloperidol	RGS2	MESH:D006220	84583(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|mRNA mRNA|compound|END_ENTITY	Different regulation of RGS2 mRNA by haloperidol and clozapine .
23246638	0	haloperidol	54,65	S100B	22,27	haloperidol	S100B	MESH:D006220	25742(Tax:10116)	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|secretion secretion|compound|END_ENTITY	Interleukin-6-induced S100B secretion is inhibited by haloperidol and risperidone .
14638382	0	haloperidol	10,21	amyloid_precursor_protein	41,66	haloperidol	amyloid precursor protein	MESH:D006220	54226(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|compound|END_ENTITY	Effect of haloperidol and risperidone on amyloid_precursor_protein levels in vivo .
18789920	0	haloperidol	85,96	c-Fos	58,63	haloperidol	c-Fos	MESH:D006220	314322(Tax:10116)	Chemical	Gene	administration|amod|START_ENTITY expression|nmod|administration expression|amod|END_ENTITY	Delta-9-tetrahydrocannabinol differently affects striatal c-Fos expression following haloperidol or clozapine administration .
20096751	0	haloperidol	62,73	c-Fos	0,5	haloperidol	c-Fos	MESH:D006220	314322(Tax:10116)	Chemical	Gene	disruption|amod|START_ENTITY associated|nmod|disruption associated|nsubj|identification identification|amod|END_ENTITY	c-Fos identification of neuroanatomical sites associated with haloperidol and clozapine disruption of maternal behavior in the rat .
26190766	0	haloperidol	91,102	c-Fos	58,63	haloperidol	c-Fos	MESH:D006220	314322(Tax:10116)	Chemical	Gene	sensitization|amod|START_ENTITY immunohistochemistry|nmod|sensitization immunohistochemistry|amod|END_ENTITY	Brain regions associated with inverse incentive learning : c-Fos immunohistochemistry after haloperidol sensitization on the bar test in rats .
9117387	0	haloperidol	24,35	c-Fos	91,96	haloperidol	c-Fos	MESH:D006220	314322(Tax:10116)	Chemical	Gene	drugs|compound|START_ENTITY effects|nmod|drugs Differential|dobj|effects Differential|nmod|expression expression|amod|END_ENTITY	Differential effects of haloperidol and two anxiolytic drugs , buspirone and lesopitron , on c-Fos expression in the rat striatum and nucleus accumbens .
9696058	0	haloperidol	58,69	c-Fos	49,54	haloperidol	c-Fos	MESH:D006220	314322(Tax:10116)	Chemical	Gene	nuclei|amod|START_ENTITY inhibit|nmod|nuclei inhibit|dobj|induction induction|nmod|END_ENTITY	Globus pallidus lesions inhibit the induction of c-Fos by haloperidol in the basal ganglia output nuclei in rats .
12842125	0	haloperidol	65,76	c-fos	101,106	haloperidol	c-fos	MESH:D006220	314322(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Bilateral lesions of the entorhinal cortex differentially modify haloperidol - and olanzapine-induced c-fos mRNA expression in the rat forebrain .
1347406	0	haloperidol	80,91	c-fos	22,27	haloperidol	c-fos	MESH:D006220	2353	Chemical	Gene	effects|nmod|START_ENTITY contrasting|dobj|effects increase|parataxis|contrasting increase|dobj|expression expression|amod|END_ENTITY	Neuroleptics increase c-fos expression in the forebrain : contrasting effects of haloperidol and clozapine .
1374894	0	haloperidol	66,77	c-fos	27,32	haloperidol	c-fos	MESH:D006220	314322(Tax:10116)	Chemical	Gene	striatum|advcl|START_ENTITY striatum|nsubj|expression expression|nmod|END_ENTITY	Differential expression of c-fos and zif268 in rat striatum after haloperidol , clozapine , and amphetamine .
7566476	0	haloperidol	50,61	c-fos	13,18	haloperidol	c-fos	MESH:D006220	314322(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Induction of c-fos , jun_B and egr-1 expression by haloperidol in PC12 cells : involvement of calcium .
8414186	0	haloperidol	84,95	c-fos	70,75	haloperidol	c-fos	MESH:D006220	14281(Tax:10090)	Chemical	Gene	reduces|nmod|START_ENTITY reduces|dobj|induction induction|nmod|gene gene|amod|END_ENTITY	The NMDA receptor antagonist MK-801 markedly reduces the induction of c-fos gene by haloperidol in the mouse striatum .
8822480	0	haloperidol	94,105	c-fos	69,74	haloperidol	c-fos	MESH:D006220	2353	Chemical	Gene	striatum|nmod|START_ENTITY END_ENTITY|nmod|striatum	Involvement of adenosine and glutamate receptors in the induction of c-fos in the striatum by haloperidol .
8361339	0	haloperidol	20,31	carboxypeptidase_E	42,60	haloperidol	carboxypeptidase E	MESH:D006220	25669(Tax:10116)	Chemical	Gene	increases|compound|START_ENTITY END_ENTITY|nsubj|increases	Dopamine antagonist haloperidol increases carboxypeptidase_E mRNA in rat neurointermediate pituitary but not in various other rat tissues .
7202372	0	haloperidol	19,30	catechol-O-methyltransferase	90,118	haloperidol	catechol-O-methyltransferase	MESH:D006220	1312	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nmod|effect	In vitro effect of haloperidol , chlorpromazine , imipramine and lithium on the erythrocyte catechol-O-methyltransferase .
2713650	0	haloperidol	32,43	cholecystokinin	92,107	haloperidol	cholecystokinin	MESH:D006220	25298(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY Effects|nmod|administration Effects|nmod|END_ENTITY	Effects of short - and long-term haloperidol administration and withdrawal on regional brain cholecystokinin and neurotensin concentrations in the rat .
8596656	0	haloperidol	11,22	chromogranins_A_and_B_and_secretogranin_II	76,118	haloperidol	chromogranins A and B and secretogranin II	MESH:D006220	24765;24258;24259	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of haloperidol , clozapine and citalopram on messenger RNA levels of chromogranins_A_and_B_and_secretogranin_II in various regions of rat brain .
10551545	0	haloperidol	95,106	cytochrome_P-450_2D6	28,48	haloperidol	cytochrome P-450 2D6	MESH:D006220	1565	Chemical	Gene	polymorphism|nmod|START_ENTITY polymorphism|amod|END_ENTITY	Genetic association between cytochrome_P-450_2D6 gene polymorphism and plasma concentration of haloperidol in Japanese schizophrenics .
16923156	0	haloperidol	24,35	erythropoietin	72,86	haloperidol	erythropoietin	MESH:D006220	24335(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|nmod|END_ENTITY	Differential effects of haloperidol and olanzapine on the expression of erythropoietin and its receptor in rat hippocampus and striatum .
6405424	0	haloperidol	10,21	glutamate_decarboxylase	25,48	haloperidol	glutamate decarboxylase	MESH:D006220	24957(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	Effect of haloperidol on glutamate_decarboxylase activity in discrete brain areas of the rat .
8843098	0	haloperidol	22,33	glutamate_receptor_subunit	47,73	haloperidol	glutamate receptor subunit	MESH:D006220	50592(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|END_ENTITY	The effect of chronic haloperidol treatment on glutamate_receptor_subunit -LRB- GluR1 , GluR2 , KA1 , KA2 , NR1 -RRB- mRNAs and glutamate_binding_protein mRNA in rat forebrain .
18721842	0	haloperidol	11,22	heat_shock_protein_70	60,81	haloperidol	heat shock protein 70	MESH:D006220	266759(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of haloperidol and risperidone on the expression of heat_shock_protein_70 in MK-801-treated rat C6_glioma cells .
15590637	0	haloperidol	10,21	mPer1	25,30	haloperidol	mPer1	MESH:D006220	18626(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effect of haloperidol on mPer1 gene expression in mouse suprachiasmatic nuclei .
16401646	0	haloperidol	19,30	neuropeptide_Y	42,56	haloperidol	neuropeptide Y	MESH:D006220	24604(Tax:10116)	Chemical	Gene	Clozapine|dep|START_ENTITY increases|nsubj|Clozapine increases|dobj|expression expression|amod|neuronal neuronal|advmod|END_ENTITY	Clozapine , but not haloperidol , increases neuropeptide_Y neuronal expression in the rat hypothalamus .
2224539	0	haloperidol	10,21	neuropeptide_Y	40,54	haloperidol	neuropeptide Y	MESH:D006220	24604(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of haloperidol on immunoreactive neuropeptide_Y in rat cerebral cortex and basal ganglia .
11927184	0	haloperidol	11,22	neurotensin	42,53	haloperidol	neurotensin	MESH:D006220	299757(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|compound|END_ENTITY	Effects of haloperidol and risperidone on neurotensin levels in brain regions and neurotensin efflux in the ventral striatum of the rat .
15165840	0	haloperidol	95,106	neurotensin	12,23	haloperidol	neurotensin	MESH:D006220	67405(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY hypo-locomotion|acl|induced affects|dobj|hypo-locomotion affects|nsubj|Blockade Blockade|nmod|receptors receptors|compound|END_ENTITY	Blockade of neurotensin receptors affects differently hypo-locomotion and catalepsy induced by haloperidol in mice .
1531499	0	haloperidol	24,35	neurotensin	53,64	haloperidol	neurotensin	MESH:D006220	299757(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|transcription transcription|compound|END_ENTITY	Differential effects of haloperidol and clozapine on neurotensin gene transcription in rat neostriatum .
1625208	0	haloperidol	112,123	neurotensin	52,63	haloperidol	neurotensin	MESH:D006220	299757(Tax:10116)	Chemical	Gene	focus|nmod|START_ENTITY studies|dep|focus studies|nmod|modulation modulation|nmod|concentrations concentrations|compound|END_ENTITY	Further studies on the modulation of regional brain neurotensin concentrations by antipsychotic drugs : focus on haloperidol and BMY_14802 .
7722490	0	haloperidol	84,95	neurotensin	12,23	haloperidol	neurotensin	MESH:D006220	299757(Tax:10116)	Chemical	Gene	accumbens|amod|START_ENTITY effect|nmod|accumbens potentiates|dobj|effect potentiates|nsubj|Blockade Blockade|nmod|receptor receptor|compound|END_ENTITY	Blockade of neurotensin receptor by SR_48692 potentiates the facilitatory effect of haloperidol on the evoked in vivo dopamine release in the rat nucleus accumbens .
7914659	0	haloperidol	87,98	neurotensin	16,27	haloperidol	neurotensin	MESH:D006220	299757(Tax:10116)	Chemical	Gene	neurons|nmod|START_ENTITY mRNAs|nmod|neurons mRNAs|nsubj|Coexpression Coexpression|nmod|END_ENTITY	Coexpression of neurotensin and c-fos mRNAs in rat neostriatal neurons following acute haloperidol .
8182549	0	haloperidol	133,144	neurotensin	13,24	haloperidol	neurotensin	MESH:D006220	299757(Tax:10116)	Chemical	Gene	effects|amod|START_ENTITY comparison|nmod|effects Induction|dep|comparison Induction|nmod|mRNA mRNA|compound|END_ENTITY	Induction of neurotensin and c-fos mRNA in distinct subregions of rat neostriatum after acute methamphetamine : comparison with acute haloperidol effects .
8358601	0	haloperidol	45,56	neurotensin	16,27	haloperidol	neurotensin	MESH:D006220	299757(Tax:10116)	Chemical	Gene	Blunting|xcomp|START_ENTITY Blunting|nmod|response response|compound|END_ENTITY	Blunting of the neurotensin mRNA response to haloperidol in the striatum of aging rats : possible relationship to decline in dopamine D2 receptor expression .
9210171	0	haloperidol	55,66	neurotensin	26,37	haloperidol	neurotensin	MESH:D006220	299757(Tax:10116)	Chemical	Gene	reduces|xcomp|START_ENTITY reduces|dobj|response response|compound|END_ENTITY	EEDQ reduces the striatal neurotensin mRNA response to haloperidol .
9298921	0	haloperidol	23,34	neurotensin	49,60	haloperidol	neurotensin	MESH:D006220	4922	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Differential effect of haloperidol on release of neurotensin in extrapyramidal and limbic systems .
7318901	0	haloperidol	10,21	ornithine_decarboxylase	33,56	haloperidol	ornithine decarboxylase	MESH:D006220	24609(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|compound|END_ENTITY	Effect of haloperidol on adrenal ornithine_decarboxylase activity of the rat .
10027514	0	haloperidol	11,22	prolactin	36,45	haloperidol	prolactin	MESH:D006220	5617	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|response response|compound|END_ENTITY	Effects of haloperidol treatment on prolactin response to D-fenfluramine challenge in acute schizophrenia .
108715	0	haloperidol	67,78	prolactin	15,24	haloperidol	prolactin	MESH:D006220	5617	Chemical	Gene	START_ENTITY|nsubj|Variability Variability|nmod|response response|compound|END_ENTITY	Variability of prolactin response to intravenous and intramuscular haloperidol in normal adult men .
12107619	0	haloperidol	47,58	prolactin	14,23	haloperidol	prolactin	MESH:D006220	5617	Chemical	Gene	treatments|amod|START_ENTITY Comparison|nmod|treatments Comparison|nmod|concentrations concentrations|compound|END_ENTITY	Comparison of prolactin concentrations between haloperidol and risperidone treatments in the same female patients with schizophrenia .
12505103	0	haloperidol	81,92	prolactin	46,55	haloperidol	prolactin	MESH:D006220	5617	Chemical	Gene	associated|xcomp|START_ENTITY associated|nmod|increase increase|nmod|secretion secretion|compound|END_ENTITY	Quetiapine is not associated with increase in prolactin secretion in contrast to haloperidol .
1310283	0	haloperidol	75,86	prolactin	34,43	haloperidol	prolactin	MESH:D006220	24683(Tax:10116)	Chemical	Gene	action|nmod|START_ENTITY mediates|dobj|action mediates|nsubj|evidence evidence|acl|suggest suggest|dobj|END_ENTITY	Indirect evidence to suggest that prolactin mediates the adrenal action of haloperidol to stimulate aldosterone and corticosterone secretion in rats .
1486148	0	haloperidol	52,63	prolactin	30,39	haloperidol	prolactin	MESH:D006220	5617	Chemical	Gene	challenge|amod|START_ENTITY response|nmod|challenge response|compound|END_ENTITY	Multidiagnostic evaluation of prolactin response to haloperidol challenge in schizophrenia : maximal blunting in Kraepelinian patients .
1625521	0	haloperidol	11,22	prolactin	95,104	haloperidol	prolactin	MESH:D006220	24683(Tax:10116)	Chemical	Gene	tumors|compound|START_ENTITY Effects|nmod|tumors Effects|nmod|END_ENTITY	Effects of haloperidol and prolactin secreting tumors on cerebrospinal fluid concentrations of prolactin in the female rat .
2114005	0	haloperidol	113,124	prolactin	15,24	haloperidol	prolactin	MESH:D006220	24683(Tax:10116)	Chemical	Gene	blockade|nmod|START_ENTITY month|nmod|blockade secretion|nmod|month secretion|nsubj|Alterations Alterations|nmod|END_ENTITY	Alterations in prolactin secretion during the 1st postnatal month following perinatal dopaminergic blockade with haloperidol .
23131886	0	haloperidol	20,31	prolactin	71,80	haloperidol	prolactin	MESH:D006220	5617	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Long-term effect of haloperidol , olanzapine , and risperidone on plasma prolactin levels in patients with first-episode psychosis .
4034625	0	haloperidol	19,30	prolactin	41,50	haloperidol	prolactin	MESH:D006220	24683(Tax:10116)	Chemical	Gene	START_ENTITY|xcomp|affect affect|xcomp|due due|nsubj|secretion secretion|compound|END_ENTITY	Failure of chronic haloperidol to affect prolactin secretion due to acute haloperidol administration .
4034625	0	haloperidol	74,85	prolactin	41,50	haloperidol	prolactin	MESH:D006220	24683(Tax:10116)	Chemical	Gene	administration|amod|START_ENTITY due|nmod|administration due|nsubj|secretion secretion|compound|END_ENTITY	Failure of chronic haloperidol to affect prolactin secretion due to acute haloperidol administration .
6120731	0	haloperidol	93,104	prolactin	71,80	haloperidol	prolactin	MESH:D006220	5617	Chemical	Gene	challenge|amod|START_ENTITY tests|nmod|challenge tests|nmod|treatment treatment|nmod|response response|compound|END_ENTITY	Neuroendocrine tests during treatment with neuroleptic drugs I. Plasma prolactin response to haloperidol challenge .
6486269	0	haloperidol	28,39	prolactin	15,24	haloperidol	prolactin	MESH:D006220	5617	Chemical	Gene	outcome|amod|START_ENTITY END_ENTITY|nmod|outcome	Ratio of serum prolactin to haloperidol and early clinical outcome in acute psychosis .
6878514	0	haloperidol	129,140	prolactin	25,34	haloperidol	prolactin	MESH:D006220	5617	Chemical	Gene	doses|nmod|START_ENTITY treated|nmod|doses treated|nsubj|relationship relationship|nmod|levels levels|compound|END_ENTITY	The relationship between prolactin levels and clinical ratings in manic patients treated with oral and intravenous test doses of haloperidol .
2868477	0	haloperidol	11,22	somatostatin-like_immunoreactivity	26,60	haloperidol	somatostatin-like immunoreactivity	MESH:D006220	25759	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of haloperidol on somatostatin-like_immunoreactivity in the CSF of Schizophrenic patients .
12354301	0	haloperidol	125,136	synapsin_II	110,121	haloperidol	synapsin II	MESH:D006220	29179(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY END_ENTITY|nmod|treatment	cDNA array reveals differential gene expression following chronic neuroleptic administration : implications of synapsin_II in haloperidol treatment .
16859894	0	haloperidol	24,35	vascular_endothelial_growth_factor	64,98	haloperidol	vascular endothelial growth factor	MESH:D006220	83785(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|levels levels|nmod|END_ENTITY	Differential effects of haloperidol and olanzapine on levels of vascular_endothelial_growth_factor and angiogenesis in rat hippocampus .
9593855	0	haloperidol_decanoate	69,90	Fos	14,17	haloperidol decanoate	Fos	MESH:C033563	314322(Tax:10116)	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|protein protein|compound|END_ENTITY	Expression of Fos protein in the limbic regions of the rat following haloperidol_decanoate .
23791	0	halopredone_acetate	10,29	tryptophan_oxygenase	43,63	halopredone acetate	tryptophan oxygenase	MESH:C015912	64206(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of halopredone_acetate on rat liver tryptophan_oxygenase and tyrosine aminotransferase activities .
4063356	0	halothane	10,19	Ca2	23,26	halothane	Ca2	MESH:D006221	54231(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|+ +|amod|END_ENTITY	Effect of halothane on Ca2 + - induced Ca2 + release from sarcoplasmic reticulum vesicles isolated from rat skeletal muscle .
15278794	0	halothane	10,19	ICAM-1	58,64	halothane	ICAM-1	MESH:D006221	3383	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of halothane on intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- in melanoma cells .
2992730	0	halothane	11,20	angiotensin_converting_enzyme	51,80	halothane	angiotensin converting enzyme	MESH:D006221	100009274(Tax:9986)	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|activity activity|amod|END_ENTITY	Enflurane , halothane and isoflurane do not inhibit angiotensin_converting_enzyme activity .
3160261	0	halothane	11,20	beta-endorphin	55,69	halothane	beta-endorphin	MESH:D006221	5443	Chemical	Gene	anesthesia|amod|START_ENTITY anesthesia|nmod|END_ENTITY	Effects of halothane and fentanyl anesthesia on plasma beta-endorphin immunoreactivity during cardiac surgery .
8434746	0	halothane	11,20	beta-endorphin	39,53	halothane	beta-endorphin	MESH:D006221	5443	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|release release|amod|END_ENTITY	Effects of halothane and isoflurane on beta-endorphin release in children .
7110119	0	halothane	24,33	cytochrome_P-450	54,70	halothane	cytochrome P-450	MESH:D006221	100328948(Tax:9986)	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|nmod|END_ENTITY	Reductive metabolism of halothane by human and rabbit cytochrome_P-450 .
7073765	0	halothane	45,54	cytochrome_P450	64,79	halothane	cytochrome P450	MESH:D006221	4051	Chemical	Gene	mechanism|nmod|START_ENTITY mechanism|nmod|END_ENTITY	The mechanism of reductive dehalogenation of halothane by liver cytochrome_P450 .
328188	0	halothane	15,24	vasopressin	35,46	halothane	vasopressin	MESH:D006221	551	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nsubj|effects	The effects of halothane on plasma vasopressin during cardio-pulmonary bypass .
3396546	0	halothane	100,109	vasopressin	48,59	halothane	vasopressin	MESH:D006221	551	Chemical	Gene	anaesthetized|nmod|START_ENTITY anaesthetized|nsubj|END_ENTITY	Renin-angiotensin-aldosterone_system and plasma vasopressin in surgical patients anaesthetized with halothane or isoflurane .
17355907	0	hamartin	22,30	NADE	46,50	hamartin	NADE	null	117089(Tax:10116)	Chemical	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The TSC1 gene product hamartin interacts with NADE .
5505688	0	harmaline	31,40	DOPA_decarboxylase	48,66	harmaline	DOPA decarboxylase	MESH:D006246	1644	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Effect of brain_lesions and of harmaline on the DOPA_decarboxylase activity in the striatum of the cat .
14660022	0	harmane	32,39	insulin	57,64	harmane	insulin	MESH:C005010	3630	Chemical	Gene	Effects|amod|START_ENTITY Effects|nmod|END_ENTITY	Effects of the beta-carbolines , harmane and pinoline , on insulin secretion from isolated human islets of Langerhans .
19548284	0	harmine	28,35	BCRP	45,49	harmine	BCRP	MESH:D006247	9429	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	The beta-carboline alkaloid harmine inhibits BCRP and can reverse resistance to the anticancer drugs mitoxantrone and camptothecin in breast_cancer cells .
22001777	0	harmine	91,98	CYP1A1	81,87	harmine	CYP1A1	MESH:D006247	13076(Tax:10090)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Transcriptional and posttranslational inhibition of dioxin-mediated induction of CYP1A1 by harmine and harmol .
21573099	0	harmine	33,40	DYRK1A	50,56	harmine	DYRK1A	MESH:D006247	1859	Chemical	Gene	compounds|nmod|START_ENTITY inhibit|nsubj|compounds inhibit|dobj|phosphorylation phosphorylation|compound|END_ENTITY	b-carboline compounds , including harmine , inhibit DYRK1A and tau phosphorylation at multiple Alzheimer 's _ disease-related sites .
21504804	0	harmine	19,26	NFATc1	37,43	harmine	NFATc1	MESH:D006247	18018(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	The small molecule harmine regulates NFATc1 and Id2 expression in osteoclast progenitor cells .
17488638	0	harmine	19,26	PPARgamma	78,87	harmine	PPARgamma	MESH:D006247	19016(Tax:10090)	Chemical	Gene	regulator|nsubj|START_ENTITY regulator|nmod|expression expression|compound|END_ENTITY	The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARgamma expression .
26526348	0	harmine	11,18	acetylcholinesterase	23,43	harmine	acetylcholinesterase	MESH:D006247	11423(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effects of harmine , an acetylcholinesterase inhibitor , on spatial learning and memory of APP/PS1 transgenic_mice and scopolamine-induced memory_impairment mice .
11797076	0	harmine	11,18	monoamine_oxidase-A	78,97	harmine	monoamine oxidase-A	MESH:D006247	29253(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|dep|role role|nmod|inhibition inhibition|amod|END_ENTITY	Effects of harmine on dopamine output and metabolism in rat striatum : role of monoamine_oxidase-A inhibition .
23300602	0	harmine	25,32	p53	106,109	harmine	p53	MESH:D006247	22060(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|activation activation|nmod|END_ENTITY	A natural small molecule harmine inhibits angiogenesis and suppresses_tumour growth through activation of p53 in endothelial cells .
9837931	0	helenalin	44,53	NF-kappaB	88,97	helenalin	NF-kappaB	MESH:C001329	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	The anti-inflammatory sesquiterpene_lactone helenalin inhibits the transcription factor NF-kappaB by directly targeting p65 .
9837931	0	helenalin	44,53	p65	120,123	helenalin	p65	MESH:C001329	5970	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	The anti-inflammatory sesquiterpene_lactone helenalin inhibits the transcription factor NF-kappaB by directly targeting p65 .
22461525	0	hemagglutinin	16,29	IL-2	47,51	hemagglutinin	IL-2	MESH:D006388	3558	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Heparin-binding hemagglutinin induces IFN-y -LRB- + -RRB- IL-2 -LRB- + -RRB- IL-17 -LRB- + -RRB- multifunctional CD4 -LRB- + -RRB- T cells during latent but not active tuberculosis_disease .
21217702	0	hemagglutinin	31,44	SLAM	76,80	hemagglutinin	SLAM	MESH:D006388	6504	Chemical	Gene	START_ENTITY|xcomp|bound bound|nmod|END_ENTITY	Structure_of_the_measles_virus hemagglutinin bound to its cellular receptor SLAM .
23202587	0	hemagglutinin	27,40	nectin-4	74,82	hemagglutinin	nectin-4	MESH:D006388	81607	Chemical	Gene	Structure|nmod|START_ENTITY bound|nsubj|Structure bound|nmod|END_ENTITY	Structure of measles_virus hemagglutinin bound to its epithelial receptor nectin-4 .
22561313	0	hemagglutinin	10,23	neuraminidase	98,111	hemagglutinin	neuraminidase	MESH:D006388	4758	Chemical	Gene	content|compound|START_ENTITY content|nmod|END_ENTITY	Increased hemagglutinin content in a reassortant 2009 pandemic H1N1 influenza virus with chimeric neuraminidase containing donor A/Puerto Rico/8/34 virus transmembrane and stalk domains .
11536166	0	hemagglutinins	21,35	NKp44	39,44	hemagglutinins	NKp44	MESH:D006388	9436	Chemical	Gene	Recognition|nmod|START_ENTITY Recognition|nmod|END_ENTITY	Recognition of viral hemagglutinins by NKp44 but not by NKp30 .
11779055	0	hematogones	21,32	CD5	14,17	hematogones	CD5	null	921	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of CD5 on hematogones in a 7-year-old girl with Shwachman-Diamond_syndrome .
18359913	0	hematoporphyrin	70,85	caspase_8	15,24	hematoporphyrin	caspase 8	MESH:D006415	12370(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of caspase_8 in apoptosis induced by ultrasound-activated hematoporphyrin in sarcoma_180 cells in vitro .
4017621	0	hematoporphyrin	82,97	main_intrinsic_protein	47,69	hematoporphyrin	main intrinsic protein	MESH:D006415	280859(Tax:9913)	Chemical	Gene	oxidation|nmod|START_ENTITY oxidation|nmod|END_ENTITY	The photosensitized oxidation of the calf lens main_intrinsic_protein -LRB- MP26 -RRB- with hematoporphyrin .
11550033	0	hematoporphyrin	122,137	myeloperoxidase	87,102	hematoporphyrin	myeloperoxidase	MESH:D006415	4353	Chemical	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	Effect of laser irradiation on functional activity of human neutrophils : activation of myeloperoxidase in the presence of hematoporphyrin .
18719978	0	heme	66,70	ALAS1	33,38	heme	ALAS1	MESH:D006418	211	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|mRNA mRNA|compound|END_ENTITY	Differential regulation of human ALAS1 mRNA and protein levels by heme and cobalt_protoporphyrin .
26105866	1	heme	43,47	Alpha-1-microglobulin	7,28	heme	Alpha-1-microglobulin	MESH:D006418	259	Chemical	Gene	protects|nmod|START_ENTITY protects|nsubj|END_ENTITY	Alpha-1-microglobulin protects from heme induced placenta_and_kidney_damage in a pregnant ewe model for preeclampsia .
14504288	0	heme	72,76	Bach1	34,39	heme	Bach1	MESH:D006418	571	Chemical	Gene	gene|amod|START_ENTITY repressor|nmod|gene END_ENTITY|appos|repressor	Cadmium induces nuclear export of Bach1 , a transcriptional repressor of heme oxygenase-1 gene .
17257585	0	heme	38,42	Bach1	12,17	heme	Bach1	MESH:D006418	12013(Tax:10090)	Chemical	Gene	induction|nmod|START_ENTITY END_ENTITY|nmod|induction	The role of Bach1 in the induction of heme oxygenase by tin mesoporphyrin .
17701549	0	heme	75,79	Bach1	0,5	heme	Bach1	MESH:D006418	571	Chemical	Gene	sites|amod|START_ENTITY presence|nmod|sites reveals|dobj|presence reveals|nsubj|END_ENTITY	Bach1 , a heme-dependent transcription factor , reveals presence of multiple heme binding sites with distinct coordination structure .
24613679	0	heme	20,24	Bach1	62,67	heme	Bach1	MESH:D006418	571	Chemical	Gene	uptake|compound|START_ENTITY regulates|nsubj|uptake regulates|dobj|repressor repressor|amod|END_ENTITY	Hemopexin-dependent heme uptake via endocytosis regulates the Bach1 transcription repressor and heme oxygenase gene activation .
25019514	0	heme	13,17	Bach1	72,77	heme	Bach1	MESH:D006418	571	Chemical	Gene	I|amod|START_ENTITY Induction|nmod|I Induction|dep|modulator modulator|nmod|activity activity|amod|END_ENTITY	Induction of heme oxygenase I -LRB- HMOX1 -RRB- by HPP-4382 : a novel modulator of Bach1 activity .
25463280	0	heme	37,41	Bach1	80,85	heme	Bach1	MESH:D006418	571	Chemical	Gene	downregulation|nmod|START_ENTITY downregulation|amod|oxygenase-1 oxygenase-1|nmod|lipopolysaccharide lipopolysaccharide|nmod|END_ENTITY	Cell-type-specific downregulation of heme oxygenase-1 by lipopolysaccharide via Bach1 in primary human mononuclear cells .
12693958	0	heme	9,13	CYP4B1	25,31	heme	CYP4B1	MESH:D006418	100008805(Tax:9986)	Chemical	Gene	START_ENTITY|xcomp|binding binding|nmod|END_ENTITY	Covalent heme binding to CYP4B1 via Glu310 and a carbocation porphyrin intermediate .
7929220	1	heme	105,109	Cystathionine_beta-synthase	72,99	heme	Cystathionine beta-synthase	MESH:D006418	24250(Tax:10116)	Chemical	Gene	protein|amod|START_ENTITY protein|nsubj|END_ENTITY	Cystathionine_beta-synthase is a heme protein .
20860521	0	heme	54,58	Cytochrome_P450	0,15	heme	Cytochrome P450	MESH:D006418	4051	Chemical	Gene	interplay|nmod|START_ENTITY regulation|dep|interplay regulation|amod|END_ENTITY	Cytochrome_P450 regulation : the interplay between its heme and apoprotein moieties in synthesis , assembly , repair , and disposal .
19721088	0	heme	82,86	Cytochrome_c	0,12	heme	Cytochrome c	MESH:D006418	54205	Chemical	Gene	modifications|nmod|START_ENTITY mechanisms|nmod|modifications biogenesis|dep|mechanisms biogenesis|amod|END_ENTITY	Cytochrome_c biogenesis : mechanisms for covalent modifications and trafficking of heme and for heme-iron redox control .
24910438	0	heme	22,26	DGCR8	4,9	heme	DGCR8	MESH:D006418	54487	Chemical	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	The DGCR8 RNA-binding heme domain recognizes primary microRNAs by clamping the hairpin .
15590657	0	heme	35,39	Ets-2	8,13	heme	Ets-2	MESH:D006418	2114	Chemical	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Role of Ets-2 in the regulation of heme oxygenase-1 by endotoxin .
8935653	0	heme	10,14	FRE1	41,45	heme	FRE1	MESH:D006418	850911(Tax:4932)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of heme and vacuole_deficiency on FRE1 gene expression and ferrireductase activity in Saccharomyces_cerevisiae .
7651346	0	heme	25,29	HAP1	61,65	heme	HAP1	MESH:D006418	850958(Tax:4932)	Chemical	Gene	control|amod|START_ENTITY control|nmod|END_ENTITY	Multiple domains mediate heme control of the yeast activator HAP1 .
8464899	0	heme	77,81	HAP1	128,132	heme	HAP1	MESH:D006418	850958(Tax:4932)	Chemical	Gene	domain|amod|START_ENTITY binding|nmod|domain END_ENTITY|amod|binding	Antibody-promoted dimerization bypasses the regulation of DNA binding by the heme domain of the yeast transcriptional activator HAP1 .
9632766	0	heme	30,34	HAP1	136,140	heme	HAP1	MESH:D006418	850958(Tax:4932)	Chemical	Gene	START_ENTITY|dep|regulation regulation|nmod|END_ENTITY	Molecular mechanism governing heme signaling in yeast : a higher-order complex mediates heme regulation of the transcriptional activator HAP1 .
9632766	0	heme	87,91	HAP1	136,140	heme	HAP1	MESH:D006418	850958(Tax:4932)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Molecular mechanism governing heme signaling in yeast : a higher-order complex mediates heme regulation of the transcriptional activator HAP1 .
8593679	0	heme	74,78	HEM13	97,102	heme	HEM13	MESH:D006418	851614(Tax:4932)	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Positive and negative elements involved in the differential regulation by heme and oxygen of the HEM13 gene -LRB- coproporphyrinogen_oxidase -RRB- in Saccharomyces_cerevisiae .
25019514	0	heme	13,17	HMOX1	31,36	heme	HMOX1	MESH:D006418	3162	Chemical	Gene	I|amod|START_ENTITY I|appos|END_ENTITY	Induction of heme oxygenase I -LRB- HMOX1 -RRB- by HPP-4382 : a novel modulator of Bach1 activity .
14726403	8	heme	1377,1381	HO-1	1273,1277	heme	HO-1	MESH:D006418	3162	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Increased HO-1 enzymatic activity in vitro enhanced proliferation of KSHV-infected DMVECs in the presence of free heme .
23395172	0	heme	22,26	HRG1	0,4	heme	HRG1	MESH:D006418	55652	Chemical	Gene	transport|amod|START_ENTITY essential|nmod|transport essential|nsubj|END_ENTITY	HRG1 is essential for heme transport from the phagolysosome of macrophages during erythrophagocytosis .
8423544	0	heme	104,108	HSP32	160,165	heme	HSP32	MESH:D006418	24451(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Induction of kidney heme_oxygenase-1 -LRB- HSP32 -RRB- mRNA and protein by ischemia/reperfusion : possible role of heme as both promotor of tissue damage and regulator of HSP32 .
10428861	0	heme	98,102	Hap1	52,56	heme	Hap1	MESH:D006418	850958(Tax:4932)	Chemical	Gene	absence|nmod|START_ENTITY dimer|nmod|absence dimer|nsubj|yeast yeast|dep|END_ENTITY	The yeast heme-responsive transcriptional activator Hap1 is a preexisting dimer in the absence of heme .
10873649	0	heme	23,27	Hap1	81,85	heme	Hap1	MESH:D006418	850958(Tax:4932)	Chemical	Gene	elements|amod|START_ENTITY analysis|nmod|elements analysis|nmod|END_ENTITY	Functional analysis of heme regulatory elements of the transcriptional activator Hap1 .
10873649	6	heme	767,771	Hap1	786,790	heme	Hap1	MESH:D006418	850958(Tax:4932)	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Our data suggest that HRM7 plays a dominant role in mediating heme activation of Hap1 in heme-sufficient cells while HRM1-6 may scavenge heme and cause a low level of Hap1 activation in heme-deficient cells .
10873649	6	heme	842,846	Hap1	786,790	heme	Hap1	MESH:D006418	850958(Tax:4932)	Chemical	Gene	mediating|advcl|START_ENTITY mediating|dobj|activation activation|nmod|END_ENTITY	Our data suggest that HRM7 plays a dominant role in mediating heme activation of Hap1 in heme-sufficient cells while HRM1-6 may scavenge heme and cause a low level of Hap1 activation in heme-deficient cells .
11212295	0	heme	23,27	Hap1	78,82	heme	Hap1	MESH:D006418	850958(Tax:4932)	Chemical	Gene	mechanism|nmod|START_ENTITY signaling|nsubj|mechanism signaling|parataxis|serves serves|nsubj|END_ENTITY	Molecular mechanism of heme signaling in yeast : the transcriptional activator Hap1 serves as the key mediator .
11689685	0	heme	111,115	Hap1	88,92	heme	Hap1	MESH:D006418	850958(Tax:4932)	Chemical	Gene	absence|nmod|START_ENTITY END_ENTITY|nmod|absence	The Hsp70-Ydj1 molecular chaperone represses the activity of the heme activator protein Hap1 in the absence of heme .
11751848	0	heme	39,43	Hap1	94,98	heme	Hap1	MESH:D006418	850958(Tax:4932)	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	The molecular chaperone Hsp90 mediates heme activation of the yeast transcriptional activator Hap1 .
14512429	1	heme	80,84	Hap1	113,117	heme	Hap1	MESH:D006418	850958(Tax:4932)	Chemical	Gene	pathway|amod|START_ENTITY steps|nmod|pathway affect|nsubj|steps affect|dobj|activity activity|amod|END_ENTITY	Multiple oxygen-responsive steps in the heme biosynthetic pathway affect Hap1 activity .
15102838	0	heme	34,38	Hap1	53,57	heme	Hap1	MESH:D006418	850958(Tax:4932)	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	A novel mode of chaperone action : heme activation of Hap1 by enhanced association of Hsp90 with the repressed Hsp70-Hap1 complex .
19519523	0	heme	40,44	Hap1	59,63	heme	Hap1	MESH:D006418	850958(Tax:4932)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|activity activity|amod|END_ENTITY	A unique mechanism of chaperone action : heme regulation of Hap1 activity involves separate control of repression and activation .
26317124	0	heme	20,24	Hem12	0,5	heme	Hem12	MESH:D006418	851617(Tax:4932)	Chemical	Gene	biosynthesis|amod|START_ENTITY enzyme|nmod|biosynthesis END_ENTITY|appos|enzyme	Hem12 , an enzyme of heme biosynthesis pathway , is monoubiquitinated by Rsp5 ubiquitin ligase in yeast cells .
22496243	0	heme	34,38	Heme_carrier_protein_1	0,22	heme	Heme carrier protein 1	MESH:D006418	113235	Chemical	Gene	transports|dobj|START_ENTITY transports|nsubj|END_ENTITY	Heme_carrier_protein_1 transports heme and is involved in heme-Fe metabolism .
12909459	0	heme	58,62	Heme_oxygenase-1	0,16	heme	Heme oxygenase-1	MESH:D006418	3162	Chemical	Gene	properties|nmod|START_ENTITY unleashing|dobj|properties END_ENTITY|parataxis|unleashing	Heme_oxygenase-1 : unleashing the protective properties of heme .
18178725	0	heme	36,40	Heme_oxygenase-1	0,16	heme	Heme oxygenase-1	MESH:D006418	513221(Tax:9913)	Chemical	Gene	depletes|dobj|START_ENTITY depletes|nsubj|induction induction|amod|END_ENTITY	Heme_oxygenase-1 induction depletes heme and attenuates pulmonary artery relaxation and guanylate cyclase activation by nitric_oxide .
24511086	0	heme	98,102	Heme_oxygenase_1	0,16	heme	Heme oxygenase 1	MESH:D006418	15368(Tax:10090)	Chemical	Gene	level|nmod|START_ENTITY controls|dobj|level expressed|advcl|controls expressed|nsubjpass|END_ENTITY	Heme_oxygenase_1 is expressed in murine erythroid cells where it controls the level of regulatory heme .
18556779	0	heme	79,83	Hemopexin	0,9	heme	Hemopexin	MESH:D006418	15458(Tax:10090)	Chemical	Gene	overload|amod|START_ENTITY model|nmod|overload prevents|nmod|model prevents|nsubj|END_ENTITY	Hemopexin prevents endothelial_damage_and_liver_congestion in a mouse model of heme overload .
20348404	6	heme	789,793	Hemopexin	725,734	heme	hemopexin	MESH:D006418	3263	Chemical	Gene	beads|amod|START_ENTITY use|nmod|beads purified|nmod|use purified|nsubjpass|END_ENTITY	Hemopexin was purified from study participants ' serum by use of heme agarose beads .
26175690	0	heme	42,46	Hemopexin	0,9	heme	Hemopexin	MESH:D006418	3263	Chemical	Gene	toxicity|amod|START_ENTITY allies|nmod|toxicity END_ENTITY|dep|allies	Hemopexin and haptoglobin : allies against heme toxicity from hemoglobin not contenders .
9500711	0	heme	56,60	Hemopexin	0,9	heme	Hemopexin	MESH:D006418	58917(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY association|nmod|receptors inhibits|dobj|association inhibits|nsubj|END_ENTITY	Hemopexin from four species inhibits the association of heme with cultured hepatoma cells or primary rat hepatocytes exhibiting a small number of species specific hemopexin receptors .
20211185	0	heme	65,69	IL-10	13,18	heme	IL-10	MESH:D006418	16153(Tax:10090)	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	The IL-12p70 / IL-10 interplay is differentially regulated by free heme and hemozoin in murine bone-marrow-derived macrophages .
4066154	0	heme	63,67	Myoglobin	0,9	heme	Myoglobin	MESH:D006418	102975021	Chemical	Gene	pocket|amod|START_ENTITY structure|nmod|pocket structure|compound|END_ENTITY	Myoglobin structure and regulation of solvent accessibility of heme pocket .
22283334	0	heme	127,131	Rv0203	48,54	heme	Rv0203	MESH:D006418	886748(Tax:83332)	Chemical	Gene	uptake|amod|START_ENTITY involved|nmod|uptake involved|nsubj|Characterization Characterization|nmod|properties properties|nmod|END_ENTITY	Characterization of heme ligation properties of Rv0203 , a secreted heme binding protein involved in Mycobacterium_tuberculosis heme uptake .
22283334	0	heme	20,24	Rv0203	48,54	heme	Rv0203	MESH:D006418	886748(Tax:83332)	Chemical	Gene	properties|amod|START_ENTITY properties|nmod|END_ENTITY	Characterization of heme ligation properties of Rv0203 , a secreted heme binding protein involved in Mycobacterium_tuberculosis heme uptake .
22283334	0	heme	67,71	Rv0203	48,54	heme	Rv0203	MESH:D006418	886748(Tax:83332)	Chemical	Gene	protein|amod|START_ENTITY involved|nsubj|protein involved|nsubj|Characterization Characterization|nmod|properties properties|nmod|END_ENTITY	Characterization of heme ligation properties of Rv0203 , a secreted heme binding protein involved in Mycobacterium_tuberculosis heme uptake .
23760277	0	heme	65,69	Rv0203	48,54	heme	Rv0203	MESH:D006418	886748(Tax:83332)	Chemical	Gene	MmpL3|amod|START_ENTITY transfers|dobj|MmpL3 transfers|nsubj|END_ENTITY	The Mycobacterium_tuberculosis secreted protein Rv0203 transfers heme to membrane proteins MmpL3 and MmpL11 .
19332149	0	heme	17,21	SDHC	43,47	heme	SDHC	MESH:D006418	6391	Chemical	Gene	residue|amod|START_ENTITY residue|nmod|END_ENTITY	Mutations in the heme b-binding residue of SDHC inhibit assembly of respiratory chain complex II in mammalian cells .
21317376	0	heme	48,52	TSPO	38,42	heme	TSPO	MESH:D006418	819389(Tax:3702)	Chemical	Gene	protein|amod|START_ENTITY protein|nsubj|END_ENTITY	The Arabidopsis multistress regulator TSPO is a heme binding membrane protein and a potential scavenger of porphyrins via an autophagy-dependent degradation mechanism .
3753872	0	heme	24,28	Tryptophan_pyrrolase	0,20	heme	Tryptophan pyrrolase	MESH:D006418	64206(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY END_ENTITY|nmod|metabolism	Tryptophan_pyrrolase in heme metabolism .
23923575	0	heme	11,15	albumin	31,38	heme	albumin	MESH:D006418	213	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of heme to human serum albumin : steady-state fluorescence , circular dichroism and optical difference spectroscopic studies .
8396971	0	heme	2,6	c-peptide	7,16	heme	c-peptide	MESH:D006418	3630	Chemical	Gene	system|amod|START_ENTITY system|amod|END_ENTITY	A heme c-peptide model system for the resonance Raman study of c-type cytochromes : characterization of the solvent-dependence of peptide-histidine-heme interactions .
12975370	0	heme	7,11	cytochrome_C	36,48	heme	cytochrome C	MESH:D006418	54205	Chemical	Gene	potentials|amod|START_ENTITY Tuning|dobj|potentials Tuning|nmod|subunit subunit|amod|END_ENTITY	Tuning heme redox potentials in the cytochrome_C subunit of photosynthetic reaction centers .
15506748	0	heme	21,25	cytochrome_C	55,67	heme	cytochrome C	MESH:D006418	54205	Chemical	Gene	methionine|amod|START_ENTITY methionine|nmod|END_ENTITY	Photodissociation of heme distal methionine in ferrous cytochrome_C revealed by subpicosecond time-resolved resonance Raman spectroscopy .
17288462	0	heme	55,59	cytochrome_C	104,116	heme	cytochrome C	MESH:D006418	54205	Chemical	Gene	integrity|amod|START_ENTITY assessment|nmod|integrity photo-cross-linked|nsubj|assessment photo-cross-linked|dobj|structures structures|amod|END_ENTITY	Direct electrochemical and spectroscopic assessment of heme integrity in multiphoton photo-cross-linked cytochrome_C structures .
23335173	0	heme	53,57	cytochrome_C	2,14	heme	cytochrome C	MESH:D006418	54205	Chemical	Gene	ligation|amod|START_ENTITY modulated|nmod|ligation modulated|nsubj|switch switch|amod|END_ENTITY	A cytochrome_C electron transfer switch modulated by heme ligation and isomerization of a peptidyl-prolyl bond .
1126948	1	heme	93,97	cytochrome_P-450	103,119	heme	cytochrome P-450	MESH:D006418	25251(Tax:10116)	Chemical	Gene	Dissociation|nmod|START_ENTITY Dissociation|nmod|END_ENTITY	Dissociation of microsomal oxidation of heme from cytochrome_P-450 .
7071415	0	heme	60,64	cytochrome_P-450	75,91	heme	cytochrome P-450	MESH:D006418	25251(Tax:10116)	Chemical	Gene	moiety|amod|START_ENTITY moiety|nmod|END_ENTITY	Covalent binding of carbon_tetrachloride metabolites to the heme moiety of cytochrome_P-450 and its degradation products .
3663604	0	heme	55,59	cytochrome_P-450scc	70,89	heme	cytochrome P-450scc	MESH:D006418	1583	Chemical	Gene	moiety|amod|START_ENTITY moiety|nmod|END_ENTITY	Effects of cholesterol analogues and inhibitors on the heme moiety of cytochrome_P-450scc : a resonance Raman study .
3718944	0	heme	54,58	cytochrome_P-450scc	69,88	heme	cytochrome P-450scc	MESH:D006418	1583	Chemical	Gene	moiety|amod|START_ENTITY moiety|nmod|END_ENTITY	Effects of cholesterol and adrenodoxin binding on the heme moiety of cytochrome_P-450scc : a resonance Raman study .
11413149	0	heme	92,96	cytochrome_P450	102,117	heme	cytochrome P450	MESH:D006418	4051	Chemical	Gene	START_ENTITY|nmod|3A4 3A4|nummod|END_ENTITY	Stimulation of cytochrome_P450 reactions by apo-cytochrome_b5 : evidence against transfer of heme from cytochrome_P450 3A4 to apo-cytochrome_b5 or heme oxygenase .
11413149	0	heme	92,96	cytochrome_P450	15,30	heme	cytochrome P450	MESH:D006418	4051	Chemical	Gene	transfer|nmod|START_ENTITY evidence|nmod|transfer Stimulation|dep|evidence Stimulation|nmod|reactions reactions|amod|END_ENTITY	Stimulation of cytochrome_P450 reactions by apo-cytochrome_b5 : evidence against transfer of heme from cytochrome_P450 3A4 to apo-cytochrome_b5 or heme oxygenase .
1784239	0	heme	91,95	cytochrome_P450	32,47	heme	cytochrome P450	MESH:D006418	4051	Chemical	Gene	adducts|compound|START_ENTITY isolation|nmod|adducts inactivation|dep|isolation inactivation|nmod|END_ENTITY	Mechanism-based inactivation of cytochrome_P450 : isolation and characterization of N-alkyl heme adducts .
18363338	0	heme	141,145	cytochrome_P450	105,120	heme	cytochrome P450	MESH:D006418	1459138(Tax:273063)	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|END_ENTITY	Modulation of redox potential and alteration in reactivity via the peroxide shunt pathway by mutation of cytochrome_P450 around the proximal heme ligand .
19345605	0	heme	23,27	cytochrome_P450	71,86	heme	cytochrome P450	MESH:D006418	4051	Chemical	Gene	proteins|amod|START_ENTITY activation|nmod|proteins activation|dep|role role|nmod|ligation ligation|nmod|END_ENTITY	C-H bond activation in heme proteins : the role of thiolate ligation in cytochrome_P450 .
19414330	0	heme	83,87	cytochrome_P450	22,37	heme	cytochrome P450	MESH:D006418	4051	Chemical	Gene	pocket|compound|START_ENTITY ligand|nmod|pocket promiscuity|nmod|ligand structure|dep|promiscuity structure|nmod|END_ENTITY	Flexible structure of cytochrome_P450 : promiscuity of ligand binding in the CYP3A4 heme pocket .
21391540	0	heme	47,51	cytochrome_P450	80,95	heme	cytochrome P450	MESH:D006418	4051	Chemical	Gene	proteins|amod|START_ENTITY dynamics|nmod|proteins Investigation|nmod|dynamics Investigation|dep|END_ENTITY	Investigation of the low frequency dynamics of heme proteins : native and mutant cytochrome_P450 -LRB- cam -RRB- and redox partner complexes .
9285065	0	heme	49,53	cytochrome_P450	63,78	heme	cytochrome P450	MESH:D006418	25251(Tax:10116)	Chemical	Gene	group|amod|START_ENTITY group|nmod|END_ENTITY	Nonenzymatic reduction of brucine_N-oxide by the heme group of cytochrome_P450 .
9705759	0	heme	102,106	cytochrome_P450	52,67	heme	cytochrome P450	MESH:D006418	4051	Chemical	Gene	shortening|nmod|START_ENTITY due|nmod|shortening bond|amod|due bond|amod|END_ENTITY	Evidence for stabilization of the low-spin state of cytochrome_P450 due to shortening of the proximal heme bond .
10625461	0	heme	8,12	cytochrome_c	43,55	heme	cytochrome c	MESH:D006418	54205	Chemical	Gene	START_ENTITY|nmod|organization organization|nmod|END_ENTITY	Role of heme in structural organization of cytochrome_c probed by semisynthesis .
10780923	0	heme	36,40	cytochrome_c	2,14	heme	cytochrome c	MESH:D006418	54205	Chemical	Gene	resistant|xcomp|START_ENTITY variant|xcomp|resistant variant|nsubj|END_ENTITY	A cytochrome_c variant resistant to heme degradation by hydrogen_peroxide .
12167054	0	heme	32,36	cytochrome_c	17,29	heme	cytochrome c	MESH:D006418	54205	Chemical	Gene	unit|amod|START_ENTITY unit|nmod:poss|END_ENTITY	Direct wiring of cytochrome_c 's heme unit to an electrode : electrochemical studies .
12237229	0	heme	54,58	cytochrome_c	9,21	heme	cytochrome c	MESH:D006418	54205	Chemical	Gene	oxidases|amod|START_ENTITY model|nmod|oxidases peroxidase|dep|model peroxidase|amod|END_ENTITY	Mesopone cytochrome_c peroxidase : functional model of heme oxygenated oxidases .
1329082	0	heme	44,48	cytochrome_c	31,43	heme	cytochrome c	MESH:D006418	54205	Chemical	Gene	structure|amod|START_ENTITY structure|amod|END_ENTITY	The role of tyrosine 67 in the cytochrome_c heme crevice structure studied by semisynthesis .
14577794	0	heme	71,75	cytochrome_c	57,69	heme	cytochrome c	MESH:D006418	54205	Chemical	Gene	degradation|amod|START_ENTITY stability|dep|degradation stability|nmod|activity activity|nmod|END_ENTITY	Kinetic stability of the peroxidase activity of unfolded cytochrome_c : heme degradation and catalyst inactivation by hydrogen_peroxide .
14733927	0	heme	37,41	cytochrome_c	76,88	heme	cytochrome c	MESH:D006418	54205	Chemical	Gene	trityrosine|nmod|START_ENTITY effect|nmod|trityrosine ligand|nsubj|effect ligand|nmod|folding folding|nmod|END_ENTITY	Hydrophobic effect of trityrosine on heme ligand exchange during folding of cytochrome_c .
15264255	0	heme	41,45	cytochrome_c	66,78	heme	cytochrome c	MESH:D006418	54205	Chemical	Gene	group|amod|START_ENTITY group|nmod|END_ENTITY	Classical force field parameters for the heme prosthetic group of cytochrome_c .
16749832	0	heme	104,108	cytochrome_c	114,126	heme	cytochrome c	MESH:D006418	54205	Chemical	Gene	START_ENTITY|nmod|oxidase oxidase|amod|END_ENTITY	Evaluation of electron-withdrawing group effects on heme_binding in designed proteins : implications for heme a in cytochrome_c oxidase .
16878907	0	heme	74,78	cytochrome_c	134,146	heme	cytochrome c	MESH:D006418	54205	Chemical	Gene	proteins|amod|START_ENTITY Raman|nmod|proteins Raman|dep|Improvement Improvement|nmod|electrochemistry electrochemistry|nmod|electrodes electrodes|amod|END_ENTITY	Towards combined electrochemistry and surface-enhanced resonance Raman of heme proteins : Improvement of diffusion electrochemistry of cytochrome_c at silver electrodes chemically modified with 4-mercaptopyridine .
169914	0	heme	65,69	cytochrome_c	89,101	heme	cytochrome c	MESH:D006418	54205	Chemical	Gene	c|amod|START_ENTITY properties|nmod|c temperature|nmod|properties effect|nmod|temperature octapeptide|nsubj|effect octapeptide|nmod|END_ENTITY	The effect of temperature on the spectroscopic properties of the heme c octapeptide from cytochrome_c .
17029408	0	heme	86,90	cytochrome_c	50,62	heme	cytochrome c	MESH:D006418	54205	Chemical	Gene	proteins|amod|START_ENTITY designed|dobj|proteins designed|csubj|Evaluating Evaluating|nmod|oxidase oxidase|amod|END_ENTITY	Evaluating the roles of the heme_a side chains in cytochrome_c oxidase using designed heme proteins .
17266270	0	heme	32,36	cytochrome_c	40,52	heme	cytochrome c	MESH:D006418	54205	Chemical	Gene	Ab_initio_molecular_dynamics|nmod|START_ENTITY Ab_initio_molecular_dynamics|nmod|END_ENTITY	Ab_initio_molecular_dynamics of heme in cytochrome_c .
17370988	0	heme	24,28	cytochrome_c	75,87	heme	cytochrome c	MESH:D006418	54205	Chemical	Gene	architecture|amod|START_ENTITY roles|nmod|architecture roles|nmod|END_ENTITY	Functional roles of the heme architecture and its environment in tetraheme cytochrome_c .
18325656	1	heme	109,113	cytochrome_c	124,136	heme	cytochrome c	MESH:D006418	54205	Chemical	Gene	cavity|amod|START_ENTITY cavity|nmod|END_ENTITY	Monitoring the structural perturbations in the heme cavity of cytochrome_c .
19061385	0	heme	58,62	cytochrome_c	113,125	heme	cytochrome c	MESH:D006418	54205	Chemical	Gene	protein|amod|START_ENTITY specificity|nmod|protein Engineering|dep|specificity Engineering|dep|creation creation|nmod|site site|nmod|peroxidase peroxidase|amod|END_ENTITY	Engineering the substrate specificity and reactivity of a heme protein : creation of an ascorbate binding site in cytochrome_c peroxidase .
19199809	0	heme	40,44	cytochrome_c	17,29	heme	cytochrome c	MESH:D006418	54205	Chemical	Gene	proteins|compound|START_ENTITY proteins|amod|END_ENTITY	Determination of cytochrome_c and other heme proteins using the reduction wave of mercury_protoporphyrin_IX groups generated by a hydroxylamine induced replacement reaction .
2159780	0	heme	80,84	cytochrome_c	25,37	heme	cytochrome c	MESH:D006418	54205	Chemical	Gene	centers|amod|START_ENTITY oxidoreduction|nmod|centers control|nmod|oxidoreduction activity|dep|control activity|nmod|oxidase oxidase|amod|END_ENTITY	Protonmotive activity of cytochrome_c oxidase : control of oxidoreduction of the heme centers by the protonmotive force in the reconstituted beef heart enzyme .
21967884	0	heme	101,105	cytochrome_c	69,81	heme	cytochrome c	MESH:D006418	54205	Chemical	Gene	iron|amod|START_ENTITY change|nmod|iron END_ENTITY|nmod|change	Nitration of tyrosines 46 and 48 induces the specific degradation of cytochrome_c upon change of the heme iron state to high-spin .
22239663	0	heme	76,80	cytochrome_c	89,101	heme	cytochrome c	MESH:D006418	54205	Chemical	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	A distal pocket Leu residue inhibits the binding of O2 and NO at the distal heme site of cytochrome_c ' .
226523	0	heme	41,45	cytochrome_c	21,33	heme	cytochrome c	MESH:D006418	54205	Chemical	Gene	octapeptide|compound|START_ENTITY octapeptide|amod|END_ENTITY	Azide binding to the cytochrome_c ferric heme octapeptide .
22978708	0	heme	18,22	cytochrome_c	49,61	heme	cytochrome c	MESH:D006418	54205	Chemical	Gene	proteins|amod|START_ENTITY proteins|dep|comparison comparison|nmod|variants variants|amod|END_ENTITY	Ligand binding to heme proteins : a comparison of cytochrome_c variants with globins .
24114362	0	heme	54,58	cytochrome_c	69,81	heme	cytochrome c	MESH:D006418	54205	Chemical	Gene	domain|amod|START_ENTITY Perturbation|nmod|domain Perturbation|nmod|END_ENTITY	Perturbation of apoptosis upon binding of tRNA to the heme domain of cytochrome_c .
25358103	0	heme	27,31	cytochrome_c	44,56	heme	cytochrome c	MESH:D006418	54205	Chemical	Gene	changes|nmod|START_ENTITY followed|nsubj|changes followed|nmod|reaction reaction|amod|END_ENTITY	Configurational changes of heme followed by cytochrome_c folding reaction .
2543970	0	heme	55,59	cytochrome_c	10,22	heme	cytochrome c	MESH:D006418	54205	Chemical	Gene	reduction|nmod|START_ENTITY Import|dep|reduction Import|nmod|END_ENTITY	Import of cytochrome_c into mitochondria : reduction of heme , mediated by NADH and flavin_nucleotides , is obligatory for its covalent linkage to apocytochrome_c .
26775610	0	heme	89,93	cytochrome_c	68,80	heme	cytochrome c	MESH:D006418	54205	Chemical	Gene	stability|amod|START_ENTITY affects|dobj|stability affects|nsubj|Disruption Disruption|nmod|network network|nmod|human human|nmod|END_ENTITY	Disruption of a hydrogen bond network in human versus spider monkey cytochrome_c affects heme crevice stability .
2821542	0	heme	167,171	cytochrome_c	154,166	heme	cytochrome c	MESH:D006418	54205	Chemical	Gene	geometry|compound|START_ENTITY geometry|amod|END_ENTITY	Spectroscopic analysis of the cytochrome_c oxidase-cytochrome_c complex : circular dichroism and magnetic circular dichroism measurements reveal change of cytochrome_c heme geometry imposed by complex formation .
2821542	0	heme	167,171	cytochrome_c	30,42	heme	cytochrome c	MESH:D006418	54205	Chemical	Gene	geometry|compound|START_ENTITY change|nmod|geometry reveal|dobj|change reveal|nsubj|analysis analysis|nmod|complex complex|amod|oxidase-cytochrome_c oxidase-cytochrome_c|amod|END_ENTITY	Spectroscopic analysis of the cytochrome_c oxidase-cytochrome_c complex : circular dichroism and magnetic circular dichroism measurements reveal change of cytochrome_c heme geometry imposed by complex formation .
2840856	0	heme	16,20	cytochrome_c	40,52	heme	cytochrome c	MESH:D006418	54205	Chemical	Gene	stereochemistry|amod|START_ENTITY stereochemistry|nmod|END_ENTITY	A change in the heme stereochemistry of cytochrome_c upon addition of sodium_dodecyl_sulfate : electron paramagnetic resonance and electronic absorption spectral study .
2984186	0	heme	43,47	cytochrome_c	77,89	heme	cytochrome c	MESH:D006418	54205	Chemical	Gene	components|compound|START_ENTITY studies|nmod|components studies|nmod|peroxidase peroxidase|amod|END_ENTITY	Magnetic circular dichroism studies on the heme and tryptophan components of cytochrome_c peroxidase .
2996606	0	heme	18,22	cytochrome_c	40,52	heme	cytochrome c	MESH:D006418	54205	Chemical	Gene	ligands|amod|START_ENTITY Identification|nmod|ligands Identification|nmod|sp sp|amod|END_ENTITY	Identification of heme axial ligands of cytochrome_c ' from Alcaligenes sp .
5219697	0	heme	33,37	cytochrome_c	51,63	heme	cytochrome c	MESH:D006418	54205	Chemical	Gene	dispersion|nmod|START_ENTITY peptide|nsubj|dispersion peptide|nmod|END_ENTITY	Optical rotatory dispersion of a heme peptide from cytochrome_c .
6268745	0	heme	51,55	cytochrome_c	75,87	heme	cytochrome c	MESH:D006418	54205	Chemical	Gene	properties|nmod|START_ENTITY study|nmod|properties undecapeptide|nsubj|study undecapeptide|nmod|spectroscopy spectroscopy|amod|END_ENTITY	A study of the electron transfer properties of the heme undecapeptide from cytochrome_c by 1H nmr spectroscopy .
7577937	0	heme	43,47	cytochrome_c	71,83	heme	cytochrome c	MESH:D006418	54205	Chemical	Gene	architecture|amod|START_ENTITY architecture|nmod|peroxidase peroxidase|amod|END_ENTITY	Effect of the His175 -- > Glu mutation on the heme pocket architecture of cytochrome_c peroxidase .
7757009	0	heme	63,67	cytochrome_c	78,90	heme	cytochrome c	MESH:D006418	54205	Chemical	Gene	pocket|compound|START_ENTITY pocket|nmod|END_ENTITY	Replacements in a conserved leucine cluster in the hydrophobic heme pocket of cytochrome_c .
8392367	1	heme	80,84	cytochrome_c	102,114	heme	cytochrome c	MESH:D006418	54205	Chemical	Gene	undecapeptide|amod|START_ENTITY dichroism|nmod|undecapeptide dichroism|nmod|solution solution|amod|END_ENTITY	Circular dichroism of the heme undecapeptide of cytochrome_c in aqueous solution .
8664277	0	heme	38,42	cytochrome_c	51,63	heme	cytochrome c	MESH:D006418	54205	Chemical	Gene	edge|amod|START_ENTITY edge|nmod|peroxidase peroxidase|amod|END_ENTITY	Altering substrate specificity at the heme edge of cytochrome_c peroxidase .
12718557	0	heme	24,28	cytoglobin	56,66	heme	cytoglobin	MESH:D006418	114757	Chemical	Gene	structure|amod|START_ENTITY structure|nmod|END_ENTITY	Characterization of the heme environmental structure of cytoglobin , a fourth globin in humans .
15070359	0	heme	25,29	cytoglobin	120,130	heme	cytoglobin	MESH:D006418	114757	Chemical	Gene	pocket|amod|START_ENTITY change|nmod|pocket larger|nsubj|change larger|nmod|END_ENTITY	Structural change of the heme pocket due to disulfide bridge formation is significantly larger for neuroglobin than for cytoglobin .
15095869	0	heme	83,87	cytoglobin	21,31	heme	cytoglobin	MESH:D006418	114757	Chemical	Gene	hexa-coordination|amod|START_ENTITY displays|amod|hexa-coordination discovered|nmod|displays type|acl|discovered structure|dep|type structure|nmod|END_ENTITY	Crystal structure of cytoglobin : the fourth globin type discovered in man displays heme hexa-coordination .
11331290	0	heme	111,115	endothelial_nitric-oxide_synthase	126,159	heme	endothelial nitric-oxide synthase	MESH:D006418	4846	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Implications for isoform-selective inhibitor design derived from the binding mode of bulky isothioureas to the heme domain of endothelial_nitric-oxide_synthase .
9558353	0	heme	40,44	endothelial_nitric_oxide_synthase	61,94	heme	endothelial nitric oxide synthase	MESH:D006418	4846	Chemical	Gene	conformation|amod|START_ENTITY conformation|nmod|END_ENTITY	Effects of various imidazole ligands on heme conformation in endothelial_nitric_oxide_synthase .
11175906	0	heme	68,72	ferrochelatase	29,43	heme	ferrochelatase	MESH:D006418	2235	Chemical	Gene	biosynthesis|amod|START_ENTITY enzyme|nmod|biosynthesis END_ENTITY|appos|enzyme	The 2.0 A structure of human ferrochelatase , the terminal enzyme of heme biosynthesis .
7126873	0	heme	11,15	glutathione_S-transferase	19,44	heme	glutathione S-transferase	MESH:D006418	373156	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of heme by glutathione_S-transferase : a possible role of the erythrocyte enzyme .
10681502	0	heme	79,83	heme_oxygenase-1	93,109	heme	heme oxygenase-1	MESH:D006418	3162	Chemical	Gene	oxidation|nmod|START_ENTITY constants|nmod|oxidation constants|nmod|END_ENTITY	Reaction intermediates and single turnover rate constants for the oxidation of heme by human heme_oxygenase-1 .
10760513	0	heme	58,62	heme_oxygenase-1	25,41	heme	heme oxygenase-1	MESH:D006418	24451(Tax:10116)	Chemical	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Crystal structure of rat heme_oxygenase-1 in complex with heme .
10793064	0	heme	69,73	heme_oxygenase-1	24,40	heme	heme oxygenase-1	MESH:D006418	15368(Tax:10090)	Chemical	Gene	protecting|nmod|START_ENTITY END_ENTITY|advcl|protecting	The indispensability of heme_oxygenase-1 in protecting against acute heme protein-induced toxicity in vivo .
11560504	0	heme	21,25	heme_oxygenase-1	123,139	heme	heme oxygenase-1	MESH:D006418	3162	Chemical	Gene	structure|nmod|START_ENTITY oxygenase|nsubj|structure oxygenase|nmod|END_ENTITY	Crystal structure of heme oxygenase from the gram-negative pathogen Neisseria_meningitidis and a comparison with mammalian heme_oxygenase-1 .
11668058	0	heme	76,80	heme_oxygenase-1	8,24	heme	heme oxygenase-1	MESH:D006418	3162	Chemical	Gene	requirement|nmod|START_ENTITY Role|dep|requirement Role|nmod|END_ENTITY	Role of heme_oxygenase-1 in hypoxia-reoxygenation : requirement of substrate heme to promote cardioprotection .
12235152	0	heme	58,62	heme_oxygenase-1	25,41	heme	heme oxygenase-1	MESH:D006418	24451(Tax:10116)	Chemical	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Crystal structure of rat heme_oxygenase-1 in complex with heme bound to azide .
12699247	0	heme	15,19	heme_oxygenase-1	60,76	heme	heme oxygenase-1	MESH:D006418	3162	Chemical	Gene	induction|amod|START_ENTITY induction|amod|END_ENTITY	Interaction of heme with nitroxyl or nitric_oxide amplifies heme_oxygenase-1 induction : involvement of the transcription factor Nrf2 .
12783778	0	heme	31,35	heme_oxygenase-1	77,93	heme	heme oxygenase-1	MESH:D006418	3162	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	An internal enhancer regulates heme - and cadmium-mediated induction of human heme_oxygenase-1 .
12924938	0	heme	113,117	heme_oxygenase-1	73,89	heme	heme oxygenase-1	MESH:D006418	24451(Tax:10116)	Chemical	Gene	complex|nmod|START_ENTITY END_ENTITY|nmod|complex	Crystal structures of ferrous and CO - , CN -LRB- - -RRB- - , and NO-bound forms of rat heme_oxygenase-1 -LRB- HO-1 -RRB- in complex with heme : structural implications for discrimination between CO and O2 in HO-1 .
15123630	0	heme	131,135	heme_oxygenase-1	13,29	heme	heme oxygenase-1	MESH:D006418	24451(Tax:10116)	Chemical	Gene	availability|amod|START_ENTITY reduction|nmod|availability expression|nmod|reduction oxidase|nmod|expression oxidase|nsubj|Induction Induction|nmod|H H|amod|inhibits inhibits|amod|END_ENTITY	Induction of heme_oxygenase-1 inhibits NAD -LRB- P -RRB- H oxidase activity by down-regulating cytochrome b558 expression via the reduction of heme availability .
16388581	0	heme	81,85	heme_oxygenase-1	44,60	heme	heme oxygenase-1	MESH:D006418	3162	Chemical	Gene	unseating|nmod|START_ENTITY END_ENTITY|acl|unseating	Alteration of the regiospecificity of human heme_oxygenase-1 by unseating of the heme but not disruption of the distal hydrogen bonding network .
16622174	0	heme	78,82	heme_oxygenase-1	47,63	heme	heme oxygenase-1	MESH:D006418	442987(Tax:9615)	Chemical	Gene	influence|nmod|START_ENTITY influence|dobj|expression expression|amod|END_ENTITY	Epithelial cell polarity and hypoxia influence heme_oxygenase-1 expression by heme in renal epithelial cells .
16953118	0	heme	126,130	heme_oxygenase-1	51,67	heme	heme oxygenase-1	MESH:D006418	3162	Chemical	Gene	oxygenase|amod|START_ENTITY activity|amod|oxygenase enhance|dobj|activity essential|xcomp|enhance essential|nsubj|effects effects|nmod|curcuminoids curcuminoids|nmod|expression expression|amod|END_ENTITY	Comparative effects of curcuminoids on endothelial heme_oxygenase-1 expression : ortho-methoxy groups are essential to enhance heme oxygenase activity and protection .
17064313	0	heme	19,23	heme_oxygenase-1	83,99	heme	heme oxygenase-1	MESH:D006418	3162	Chemical	Gene	oxygenase-2|amod|START_ENTITY Down-regulation|nmod|oxygenase-2 associated|nsubjpass|Down-regulation associated|nmod|expression expression|nmod|END_ENTITY	Down-regulation of heme oxygenase-2 is associated with the increased expression of heme_oxygenase-1 in human cell lines .
17292349	0	heme	14,18	heme_oxygenase-1	54,70	heme	heme oxygenase-1	MESH:D006418	24451(Tax:10116)	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|END_ENTITY	Modulation by heme and zinc_protoporphyrin of colonic heme_oxygenase-1 and experimental inflammatory_bowel_disease in the rat .
19135260	0	heme	9,13	heme_oxygenase-1	49,65	heme	heme oxygenase-1	MESH:D006418	3162	Chemical	Gene	attachment|compound|START_ENTITY attachment|nmod|protein protein|nmod|END_ENTITY	Covalent heme attachment to the protein in human heme_oxygenase-1 with selenocysteine replacing the His25 proximal iron ligand .
20679134	0	heme	47,51	heme_oxygenase-1	6,22	heme	heme oxygenase-1	MESH:D006418	3162	Chemical	Gene	catabolizes|dobj|START_ENTITY catabolizes|advmod|efficiently efficiently|nmod:npmod|END_ENTITY	Human heme_oxygenase-1 efficiently catabolizes heme in the absence of biliverdin_reductase .
20732302	0	heme	8,12	heme_oxygenase-1	27,43	heme	heme oxygenase-1	MESH:D006418	3162	Chemical	Gene	catabolism|compound|START_ENTITY catabolism|nmod|END_ENTITY	Altered heme catabolism by heme_oxygenase-1 caused by mutations in human NADPH cytochrome P450 reductase .
21721581	0	heme	70,74	heme_oxygenase-1	41,57	heme	heme oxygenase-1	MESH:D006418	3162	Chemical	Gene	HO-1|nmod|START_ENTITY HO-1|amod|END_ENTITY	Caveolin-1 is a competitive inhibitor of heme_oxygenase-1 -LRB- HO-1 -RRB- with heme : identification of a minimum sequence in caveolin-1 for binding to HO-1 .
22859313	0	heme	132,136	heme_oxygenase-1	48,64	heme	heme oxygenase-1	MESH:D006418	15368(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY roles|nmod|metabolism enzymes|nmod|roles derived|nsubj|enzymes derived|ccomp|intermediates intermediates|xcomp|induce induce|xcomp|END_ENTITY	Heme and heme biosynthesis intermediates induce heme_oxygenase-1 and cytochrome_P450_2A5 , enzymes with putative sequential roles in heme and bilirubin metabolism : different requirement for transcription factor nuclear factor erythroid - derived 2-like 2 .
23068042	0	heme	17,21	heme_oxygenase-1	57,73	heme	heme oxygenase-1	MESH:D006418	3162	Chemical	Gene	sensor|amod|START_ENTITY Development|nmod|sensor labeled|nsubj|Development labeled|xcomp|END_ENTITY	Development of a heme sensor using fluorescently labeled heme_oxygenase-1 .
7577927	0	heme	98,102	heme_oxygenase-1	78,94	heme	heme oxygenase-1	MESH:D006418	24451(Tax:10116)	Chemical	Gene	metals|amod|START_ENTITY coordinated|nmod|metals coordinated|nmod|that that|nmod|END_ENTITY	Expression of the mRNA of heme-binding protein 23 is coordinated with that of heme_oxygenase-1 by heme and heavy metals in primary rat hepatocytes and hepatoma cells .
7609642	0	heme	119,123	heme_oxygenase-1	27,43	heme	heme oxygenase-1	MESH:D006418	24451(Tax:10116)	Chemical	Gene	antibody|amod|START_ENTITY aid|nmod|antibody determined|nmod|aid determined|nsubj|expression expression|nmod|neurons neurons|amod|END_ENTITY	Differential expression of heme_oxygenase-1 in cultured cortical neurons and astrocytes determined by the aid of a new heme oxygenase antibody .
7626076	0	heme	14,18	heme_oxygenase-1	114,130	heme	heme oxygenase-1	MESH:D006418	24451(Tax:10116)	Chemical	Gene	mRNA|amod|START_ENTITY Regulation|nmod|mRNA Regulation|dep|modulates modulates|dep|mRNA mRNA|amod|END_ENTITY	Regulation of heme oxygenase mRNA in mesangial cells : prostaglandin_E2 negatively modulates interleukin-1-induced heme_oxygenase-1 mRNA .
7872792	0	heme	59,63	heme_oxygenase-1	78,94	heme	heme oxygenase-1	MESH:D006418	24451(Tax:10116)	Chemical	Gene	START_ENTITY|acl|ligand ligand|nmod|END_ENTITY	Demonstration that histidine 25 , but not 132 , is the axial heme ligand in rat heme_oxygenase-1 .
8423544	0	heme	104,108	heme_oxygenase-1	20,36	heme	heme oxygenase-1	MESH:D006418	24451(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY Induction|dep|role Induction|nmod|kidney kidney|dep|mRNA mRNA|amod|END_ENTITY	Induction of kidney heme_oxygenase-1 -LRB- HSP32 -RRB- mRNA and protein by ischemia/reperfusion : possible role of heme as both promotor of tissue damage and regulator of HSP32 .
8764571	0	heme	14,18	heme_oxygenase-1	79,95	heme	heme oxygenase-1	MESH:D006418	3162	Chemical	Gene	Expression|nmod|START_ENTITY oxygenase|nsubj|Expression oxygenase|nmod|brain brain|nmod|END_ENTITY	Expression of heme oxygenase isozyme mRNAs in the human brain and induction of heme_oxygenase-1 by nitric_oxide donors .
9757125	0	heme	124,128	heme_oxygenase-1	91,107	heme	heme oxygenase-1	MESH:D006418	24451(Tax:10116)	Chemical	Gene	studies|nmod|START_ENTITY studies|nmod|form form|nmod|END_ENTITY	Crystallization and preliminary X-ray diffraction studies on the water soluble form of rat heme_oxygenase-1 in complex with heme .
10218639	0	heme	36,40	heme_oxygenase_1	99,115	heme	heme oxygenase 1	MESH:D006418	3162	Chemical	Gene	release|nmod|START_ENTITY correlates|nsubj|release correlates|nmod|induction induction|nmod|transcription transcription|amod|END_ENTITY	Cyclooxygenase dependent release of heme from microsomal hemeproteins correlates with induction of heme_oxygenase_1 transcription in human fibroblasts .
1008494	0	heme	29,33	hemopexin	37,46	heme	hemopexin	MESH:D006418	58917(Tax:10116)	Chemical	Gene	binding|nmod|START_ENTITY binding|nmod|END_ENTITY	The binding and transport of heme by hemopexin .
10504726	0	heme	61,65	hemopexin	21,30	heme	hemopexin	MESH:D006418	3263	Chemical	Gene	site|compound|START_ENTITY reveals|dobj|site reveals|nsubj|structure structure|nmod|END_ENTITY	Crystal structure of hemopexin reveals a novel high-affinity heme site formed between two beta-propeller domains .
11229523	0	heme	101,105	hemopexin	91,100	heme	hemopexin	MESH:D006418	3263	Chemical	Gene	system|amod|START_ENTITY system|amod|END_ENTITY	Links between cell-surface events involving redox-active copper and gene regulation in the hemopexin heme transport system .
11356570	0	heme	105,109	hemopexin	45,54	heme	hemopexin	MESH:D006418	3263	Chemical	Gene	limitation|amod|START_ENTITY overcome|dobj|limitation degradation|acl|overcome inhibition|dep|degradation inhibition|nmod|Bacteroides_fragilis Bacteroides_fragilis|nmod|END_ENTITY	Growth inhibition of Bacteroides_fragilis by hemopexin : proteolytic degradation of hemopexin to overcome heme limitation .
11356570	0	heme	105,109	hemopexin	83,92	heme	hemopexin	MESH:D006418	3263	Chemical	Gene	limitation|amod|START_ENTITY overcome|dobj|limitation degradation|acl|overcome degradation|nmod|END_ENTITY	Growth inhibition of Bacteroides_fragilis by hemopexin : proteolytic degradation of hemopexin to overcome heme limitation .
1542695	0	heme	112,116	hemopexin	132,141	heme	hemopexin	MESH:D006418	3263	Chemical	Gene	binding|nmod|START_ENTITY necessary|nmod|binding Identification|amod|necessary bound|nsubj|Identification bound|nmod|END_ENTITY	Identification of a genetic locus of Haemophilus_influenzae type b necessary for the binding and utilization of heme bound to human hemopexin .
17712531	0	heme	100,104	hemopexin	20,29	heme	hemopexin	MESH:D006418	3263	Chemical	Gene	uptake|amod|START_ENTITY relevance|nmod|uptake investigation|dep|relevance investigation|nmod|properties properties|amod|END_ENTITY	An investigation of hemopexin redox properties by spectroelectrochemistry : biological relevance for heme uptake .
18044975	0	heme	36,40	hemopexin	69,78	heme	hemopexin	MESH:D006418	3263	Chemical	Gene	isoforms|amod|START_ENTITY isoforms|nmod|END_ENTITY	Chromatographically distinguishable heme insertion isoforms of human hemopexin .
20430887	0	heme	181,185	hemopexin	73,82	heme	hemopexin	MESH:D006418	3263	Chemical	Gene	group|amod|START_ENTITY dissociation|nmod|group complex|nmod|dissociation hemopexin-heme|amod|complex stability|nmod|hemopexin-heme examined|nsubjpass|stability pH.|acl:relcl|examined ions|nmod|pH. ions|dep|regulate regulate|nmod|END_ENTITY	Metal ions and electrolytes regulate the dissociation of heme from human hemopexin at physiological pH. The stability of the hemopexin-heme -LRB- Hx-heme -RRB- complex to dissociation of the heme prosthetic group has been examined in bicarbonate buffers in the presence and absence of various divalent metal ions .
20430887	0	heme	57,61	hemopexin	73,82	heme	hemopexin	MESH:D006418	3263	Chemical	Gene	dissociation|nmod|START_ENTITY regulate|dobj|dissociation regulate|nmod|END_ENTITY	Metal ions and electrolytes regulate the dissociation of heme from human hemopexin at physiological pH. The stability of the hemopexin-heme -LRB- Hx-heme -RRB- complex to dissociation of the heme prosthetic group has been examined in bicarbonate buffers in the presence and absence of various divalent metal ions .
23350672	0	heme	68,72	hemopexin	33,42	heme	hemopexin	MESH:D006418	3263	Chemical	Gene	homeostasis|compound|START_ENTITY control|nmod|homeostasis modeling|dep|control Mechanisms|dep|modeling Mechanisms|nmod|neuroprotection neuroprotection|nmod|END_ENTITY	Mechanisms of neuroprotection by hemopexin : modeling the control of heme and iron homeostasis in brain neurons in inflammatory states .
2833500	0	heme	87,91	hemopexin	55,64	heme	hemopexin	MESH:D006418	15458(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY Importance|nmod|transport Importance|nmod|END_ENTITY	Importance of ligand-induced conformational changes in hemopexin for receptor-mediated heme transport .
3372521	0	heme	122,126	hemopexin	54,63	heme	hemopexin	MESH:D006418	15458(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY determinants|nmod|transport probe|dobj|determinants END_ENTITY|xcomp|probe	Use of hemopexin domains and monoclonal antibodies to hemopexin to probe the molecular determinants of hemopexin-mediated heme transport .
3372521	0	heme	122,126	hemopexin	7,16	heme	hemopexin	MESH:D006418	15458(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY determinants|nmod|transport probe|dobj|determinants hemopexin|xcomp|probe Use|xcomp|hemopexin Use|nmod|domains domains|compound|END_ENTITY	Use of hemopexin domains and monoclonal antibodies to hemopexin to probe the molecular determinants of hemopexin-mediated heme transport .
3372522	0	heme	68,72	hemopexin	15,24	heme	hemopexin	MESH:D006418	15458(Tax:10090)	Chemical	Gene	oxygenase|amod|START_ENTITY inhibitor|nmod|oxygenase Interaction|appos|inhibitor Interaction|nmod|END_ENTITY	Interaction of hemopexin with Sn-protoporphyrin_IX , an inhibitor of heme oxygenase .
3372522	1	heme	171,175	hemopexin	93,102	heme	hemopexin	MESH:D006418	15458(Tax:10090)	Chemical	Gene	oxygenase|amod|START_ENTITY mRNA|nmod|oxygenase Role|nmod|mRNA Role|nmod|END_ENTITY	Role for hemopexin in hepatic uptake of Sn-protoporphyrin_IX and induction of mRNA for heme oxygenase .
666618	1	heme	122,126	hemopexin	89,98	heme	hemopexin	MESH:D006418	3263	Chemical	Gene	Evidence|nmod|START_ENTITY Evidence|nmod|interaction interaction|nmod|END_ENTITY	Evidence for an interaction of hemopexin with myoglobin-derived heme .
667170	0	heme	80,84	hemopexin	12,21	heme	hemopexin	MESH:D006418	3263	Chemical	Gene	point|nmod|START_ENTITY change|nmod|point evidence|nmod|change END_ENTITY|dep|evidence	Human serum hemopexin : direct evidence for change of its isoelectric point upon heme binding .
6873291	0	heme	73,77	hemopexin	62,71	heme	hemopexin	MESH:D006418	58917(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|studies studies|nmod|parameters parameters|nmod|binding binding|nmod|END_ENTITY	In vitro studies on some parameters of the binding of the rat hemopexin -- heme complex with the hepatic membrane receptor .
7108353	0	heme	10,14	hemopexin	33,42	heme	hemopexin	MESH:D006418	711007(Tax:9544)	Chemical	Gene	administration|amod|START_ENTITY Effect|nmod|administration Effect|nmod|metabolism metabolism|compound|END_ENTITY	Effect of heme administration on hemopexin metabolism in the rhesus_monkey .
7363892	0	heme	46,50	hemopexin	20,29	heme	hemopexin	MESH:D006418	58917(Tax:10116)	Chemical	Gene	binding|amod|START_ENTITY Modification|nmod|binding Modification|nmod|properties properties|compound|END_ENTITY	Modification of rat hemopexin properties upon heme binding .
8076930	0	heme	96,100	hemopexin	11,20	heme	hemopexin	MESH:D006418	58917(Tax:10116)	Chemical	Gene	oxygenase|amod|START_ENTITY Effects|nmod|oxygenase Effects|nmod|END_ENTITY	Effects of hemopexin on heme-mediated repression of 5-aminolevulinate synthase and induction of heme oxygenase in cultured hepatocytes .
8574350	0	heme	46,50	hemopexin	54,63	heme	hemopexin	MESH:D006418	3263	Chemical	Gene	complexation|nmod|START_ENTITY effects|nmod|complexation studies|nmod|effects studies|nmod|END_ENTITY	EPR studies on the effects of complexation of heme by hemopexin upon its reactions with organic peroxides .
9500711	0	heme	56,60	hemopexin	163,172	heme	hemopexin	MESH:D006418	58917(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	Hemopexin from four species inhibits the association of heme with cultured hepatoma cells or primary rat hepatocytes exhibiting a small number of species specific hemopexin receptors .
971416	0	heme	12,16	hemopexin	38,47	heme	hemopexin	MESH:D006418	3263	Chemical	Gene	Transfer|nmod|START_ENTITY Transfer|nmod|END_ENTITY	Transfer of heme from heme-albumin to hemopexin .
11923316	0	heme	22,26	hsp90	0,5	heme	hsp90	MESH:D006418	3320	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	hsp90 is required for heme binding and activation of apo-neuronal nitric-oxide synthase : geldanamycin-mediated oxidant generation is unrelated to any action of hsp90 .
1238396	0	heme	47,51	insulin	17,24	heme	insulin	MESH:D006418	396145(Tax:9031)	Chemical	Gene	synthesis|compound|START_ENTITY Effects|nmod|synthesis Effects|nmod|END_ENTITY	Effects by heme , insulin , and serum albumin on heme and protein synthesis in chick embryo liver cells cultured in a chemically defined medium , and a spectrofluorometric assay for porphyrin composition .
3790490	0	heme	54,58	lactoperoxidase	31,46	heme	lactoperoxidase	MESH:D006418	4025	Chemical	Gene	environment|amod|START_ENTITY END_ENTITY|nmod|environment	Structural characterization of lactoperoxidase in the heme environment by proton NMR spectroscopy .
9774411	0	heme	4,8	lactoperoxidase	29,44	heme	lactoperoxidase	MESH:D006418	280844(Tax:9913)	Chemical	Gene	group|amod|START_ENTITY group|nmod|END_ENTITY	The heme prosthetic group of lactoperoxidase .
6682101	0	heme	72,76	leghemoglobin	95,108	heme	leghemoglobin	MESH:D006418	100527427	Chemical	Gene	pocket|amod|START_ENTITY pocket|nmod|END_ENTITY	Proton nuclear magnetic resonance study of the dynamic stability of the heme pocket of soybean leghemoglobin a. Exchange rates for the labile proton of the proximal histidyl_imidazole .
9536042	0	heme	45,49	leghemoglobin	60,73	heme	leghemoglobin	MESH:D006418	100527427	Chemical	Gene	moiety|amod|START_ENTITY moiety|nmod|END_ENTITY	Evidence that the plant host synthesizes the heme moiety of leghemoglobin in root nodules Although it is well established that the plant host encodes and synthesizes the apoprotein for leghemoglobin in root nodules , the source of the heme moiety has been uncertain .
18467329	0	heme	12,16	methemoglobin	35,48	heme	methemoglobin	MESH:D006418	3048	Chemical	Gene	uptake|amod|START_ENTITY uptake|nmod|END_ENTITY	Pathway for heme uptake from human methemoglobin by the iron-regulated surface determinants system of Staphylococcus_aureus .
6264989	0	heme	33,37	methemoglobin	48,61	heme	methemoglobin	MESH:D006418	3048	Chemical	Gene	region|amod|START_ENTITY region|nmod|END_ENTITY	Interactions of solvent with the heme region of methemoglobin and fluoro-methemoglobin .
2174260	0	heme	122,126	myeloperoxidase	137,152	heme	myeloperoxidase	MESH:D006418	4353	Chemical	Gene	pocket|compound|START_ENTITY pocket|nmod|END_ENTITY	Metal-ligand vibrations of cyanoferric myeloperoxidase and cyanoferric horseradish peroxidase : evidence for a constrained heme pocket in myeloperoxidase .
7840679	0	heme	23,27	myeloperoxidase	31,46	heme	myeloperoxidase	MESH:D006418	4353	Chemical	Gene	Structure|nmod|START_ENTITY Structure|nmod|END_ENTITY	Structure of the green heme in myeloperoxidase .
8132563	0	heme	48,52	myeloperoxidase	63,78	heme	myeloperoxidase	MESH:D006418	4353	Chemical	Gene	pocket|compound|START_ENTITY pocket|nmod|END_ENTITY	Aromatic substrate molecules bind at the distal heme pocket of myeloperoxidase .
10360958	0	heme	18,22	myoglobin	54,63	heme	myoglobin	MESH:D006418	4151	Chemical	Gene	ligand|amod|START_ENTITY ligand|nmod|END_ENTITY	Assignment of the heme axial ligand -LRB- s -RRB- for the ferric myoglobin -LRB- H93G -RRB- and heme oxygenase -LRB- H25A -RRB- cavity mutants as oxygen donors using magnetic circular dichroism .
10720470	0	heme	82,86	myoglobin	49,58	heme	myoglobin	MESH:D006418	4151	Chemical	Gene	role|nmod|START_ENTITY oxidation|dep|role oxidation|nmod|END_ENTITY	Enhanced lipid oxidation by oxidatively modified myoglobin : role of protein-bound heme .
11087949	0	heme	55,59	myoglobin	12,21	heme	myoglobin	MESH:D006418	102975021	Chemical	Gene	environment|amod|START_ENTITY END_ENTITY|dep|environment	A primitive myoglobin from Tetrahymena_pyriformis : its heme environment , autoxidizability , and genomic DNA structure .
11151505	0	heme	70,74	myoglobin	9,18	heme	myoglobin	MESH:D006418	4151	Chemical	Gene	proteins|compound|START_ENTITY template|nmod|proteins mutant|nmod|template mutant|compound|END_ENTITY	The H93G myoglobin cavity mutant as a versatile template for modeling heme proteins : ferrous , ferric , and ferryl mixed-ligand complexes with imidazole in the cavity .
1150657	0	heme	75,79	myoglobin	31,40	heme	myoglobin	MESH:D006418	100054434(Tax:9796)	Chemical	Gene	groups|nmod|START_ENTITY formylation|nmod|groups Decrease|nmod|formylation Decrease|nmod|affinity affinity|nmod|END_ENTITY	Decrease in oxygen affinity of myoglobin by formylation of vinyl groups of heme .
11601966	0	heme	119,123	myoglobin	161,170	heme	myoglobin	MESH:D006418	4151	Chemical	Gene	enzymes|amod|START_ENTITY enzymes|nmod|engineering engineering|nmod|END_ENTITY	Investigations of the roles of the distal heme environment and the proximal heme_iron ligand in peroxide activation by heme enzymes via molecular engineering of myoglobin .
11601966	0	heme	42,46	myoglobin	161,170	heme	myoglobin	MESH:D006418	4151	Chemical	Gene	environment|compound|START_ENTITY roles|nmod|environment Investigations|nmod|roles ligand|nsubj|Investigations ligand|nmod|enzymes enzymes|nmod|engineering engineering|nmod|END_ENTITY	Investigations of the roles of the distal heme environment and the proximal heme_iron ligand in peroxide activation by heme enzymes via molecular engineering of myoglobin .
1169971	2	heme	154,158	myoglobin	180,189	heme	myoglobin	MESH:D006418	100054434(Tax:9796)	Chemical	Gene	environments|amod|START_ENTITY environments|nmod|derivatives derivatives|compound|END_ENTITY	Hindered rotation of heme side methyl group as a probe for studying van_der Waals contacts in the heme side environments of myoglobin derivatives .
1169971	2	heme	77,81	myoglobin	180,189	heme	myoglobin	MESH:D006418	100054434(Tax:9796)	Chemical	Gene	group|amod|START_ENTITY rotation|nmod|group Waals|nsubj|rotation Waals|dobj|contacts contacts|nmod|environments environments|nmod|derivatives derivatives|compound|END_ENTITY	Hindered rotation of heme side methyl group as a probe for studying van_der Waals contacts in the heme side environments of myoglobin derivatives .
11772036	0	heme	63,67	myoglobin	96,105	heme	myoglobin	MESH:D006418	4151	Chemical	Gene	formation|nmod|START_ENTITY Characteristics|nmod|formation cross-linking|nsubj|Characteristics cross-linking|nmod|END_ENTITY	Characteristics and mechanism of formation of peroxide-induced heme to protein cross-linking in myoglobin .
15485667	0	heme	36,40	myoglobin	73,82	heme	myoglobin	MESH:D006418	4151	Chemical	Gene	reaction|amod|START_ENTITY reaction|nmod|END_ENTITY	Steric effects of isoleucine 107 on heme reorientation reaction in human myoglobin .
15631446	0	heme	92,96	myoglobin	35,44	heme	myoglobin	MESH:D006418	100054434(Tax:9796)	Chemical	Gene	reconstituted|nmod|START_ENTITY END_ENTITY|acl|reconstituted	Unusual ligand discrimination by a myoglobin reconstituted with a hydrophobic domain-linked heme .
15756816	0	heme	15,19	myoglobin	84,93	heme	myoglobin	MESH:D006418	4151	Chemical	Gene	complexes|compound|START_ENTITY designed|nsubj|complexes designed|xcomp|mimic mimic|dobj|environment environment|nmod|END_ENTITY	Oxygen-binding heme complexes of peptides designed to mimic the heme environment of myoglobin and hemoglobin .
15756816	0	heme	64,68	myoglobin	84,93	heme	myoglobin	MESH:D006418	4151	Chemical	Gene	environment|amod|START_ENTITY environment|nmod|END_ENTITY	Oxygen-binding heme complexes of peptides designed to mimic the heme environment of myoglobin and hemoglobin .
15756817	0	heme	18,22	myoglobin	87,96	heme	myoglobin	MESH:D006418	17189(Tax:10090)	Chemical	Gene	complexes|amod|START_ENTITY Immunogenicity|nmod|complexes designed|nsubj|Immunogenicity designed|xcomp|mimic mimic|dobj|environment environment|nmod|END_ENTITY	Immunogenicity of heme complexes of peptides designed to mimic the heme environment of myoglobin and hemoglobin .
15756817	0	heme	67,71	myoglobin	87,96	heme	myoglobin	MESH:D006418	17189(Tax:10090)	Chemical	Gene	environment|amod|START_ENTITY environment|nmod|END_ENTITY	Immunogenicity of heme complexes of peptides designed to mimic the heme environment of myoglobin and hemoglobin .
15962935	0	heme	49,53	myoglobin	78,87	heme	myoglobin	MESH:D006418	4151	Chemical	Gene	production|nmod|START_ENTITY inhibits|dobj|production inhibits|nmod|END_ENTITY	Desferrioxamine inhibits production of cytotoxic heme to protein cross-linked myoglobin : a mechanism to protect against oxidative stress without iron chelation .
16331725	0	heme	30,34	myoglobin	56,65	heme	myoglobin	MESH:D006418	4151	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Coulomb effects in binding of heme in gas-phase ions of myoglobin .
1660880	0	heme	58,62	myoglobin	94,103	heme	myoglobin	MESH:D006418	4151	Chemical	Gene	pocket|compound|START_ENTITY pocket|nmod|END_ENTITY	EPR characterization of the stereochemistry of the distal heme pocket of the engineered human myoglobin mutants .
16774917	0	heme	41,45	myoglobin	93,102	heme	myoglobin	MESH:D006418	102975021	Chemical	Gene	START_ENTITY|nmod|protein protein|nmod|binding/dissociation binding/dissociation|nmod|END_ENTITY	Pathway of information transmission from heme to protein upon ligand binding/dissociation in myoglobin revealed by UV resonance raman spectroscopy .
17388441	0	heme	50,54	myoglobin	107,116	heme	myoglobin	MESH:D006418	4151	Chemical	Gene	cooling|compound|START_ENTITY cooling|nmod|photolysis photolysis|nmod|END_ENTITY	Molecular dynamics study on the solvent dependent heme cooling following ligand photolysis in carbonmonoxy myoglobin .
17410384	0	heme	13,17	myoglobin	58,67	heme	myoglobin	MESH:D006418	4151	Chemical	Gene	Evidence|nmod|START_ENTITY release|nsubj|Evidence release|nmod|assemblies assemblies|nmod|END_ENTITY	Evidence for heme release in layer-by-layer assemblies of myoglobin and polystyrenesulfonate on pyrolitic graphite .
1850746	0	heme	51,55	myoglobin	30,39	heme	myoglobin	MESH:D006418	100054434(Tax:9796)	Chemical	Gene	group|compound|START_ENTITY group|amod|END_ENTITY	Differential additions to the myoglobin prosthetic heme group .
19622342	0	heme	112,116	myoglobin	79,88	heme	myoglobin	MESH:D006418	4151	Chemical	Gene	coordination|amod|START_ENTITY END_ENTITY|nmod|coordination	Effects of urea and acetic_acid on the heme axial ligation structure of ferric myoglobin at very acidic pH. The heme iron coordination of ferric myoglobin -LRB- Mb -RRB- in the presence of 9.0 M urea and 8.0 M acetic_acid at acidic pH values has been probed by electronic absorption , magnetic circular dichroism and resonance Raman spectroscopic techniques .
19622342	0	heme	39,43	myoglobin	79,88	heme	myoglobin	MESH:D006418	4151	Chemical	Gene	structure|amod|START_ENTITY structure|nmod|END_ENTITY	Effects of urea and acetic_acid on the heme axial ligation structure of ferric myoglobin at very acidic pH. The heme iron coordination of ferric myoglobin -LRB- Mb -RRB- in the presence of 9.0 M urea and 8.0 M acetic_acid at acidic pH values has been probed by electronic absorption , magnetic circular dichroism and resonance Raman spectroscopic techniques .
1991102	0	heme	46,50	myoglobin	25,34	heme	myoglobin	MESH:D006418	102975021	Chemical	Gene	structure|amod|START_ENTITY studies|dep|structure studies|nmod|END_ENTITY	Spectroscopic studies of myoglobin at low pH : heme structure and ligation .
1991103	0	heme	46,50	myoglobin	25,34	heme	myoglobin	MESH:D006418	4151	Chemical	Gene	kinetics|amod|START_ENTITY studies|dep|kinetics studies|nmod|END_ENTITY	Spectroscopic studies of myoglobin at low pH : heme ligation kinetics .
2018499	0	heme	93,97	myoglobin	129,138	heme	myoglobin	MESH:D006418	100054434(Tax:9796)	Chemical	Gene	resonances|amod|START_ENTITY resonances|nmod|END_ENTITY	1H NMR resonance assignments in a paramagnetic heme protein by two-dimensional spectroscopy : heme resonances in equine met-azido myoglobin .
20392104	0	heme	10,14	myoglobin	50,59	heme	myoglobin	MESH:D006418	4151	Chemical	Gene	modification|amod|START_ENTITY Effect|nmod|modification Effect|nmod|END_ENTITY	Effect of heme modification on oxygen affinity of myoglobin and equilibrium of the acid-alkaline transition in metmyoglobin .
20540498	0	heme	8,12	myoglobin	46,55	heme	myoglobin	MESH:D006418	102975021	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|unfolding unfolding|nmod|END_ENTITY	Role of heme in the unfolding and assembly of myoglobin .
21600316	0	heme	12,16	myoglobin	54,63	heme	myoglobin	MESH:D006418	4151	Chemical	Gene	Dynamics|nmod|START_ENTITY Dynamics|dep|study study|nmod|END_ENTITY	Dynamics of heme in hemoproteins : proton NMR study of myoglobin reconstituted with iron_3-ethyl-2-methylporphyrin .
22366232	0	heme	28,32	myoglobin	57,66	heme	myoglobin	MESH:D006418	100329203(Tax:8022)	Chemical	Gene	pocket|compound|START_ENTITY Insights|nmod|pocket Insights|nmod|END_ENTITY	Insights into the anomalous heme pocket of rainbow_trout myoglobin .
22877248	0	heme	106,110	myoglobin	89,98	heme	myoglobin	MESH:D006418	100054434(Tax:9796)	Chemical	Gene	due|xcomp|START_ENTITY END_ENTITY|xcomp|due	Marked difference in the electronic structure of cyanide-ligated ferric protoglobins and myoglobin due to heme ruffling .
23478515	0	heme	49,53	myoglobin	57,66	heme	myoglobin	MESH:D006418	4151	Chemical	Gene	shape|nmod|START_ENTITY rearranged|dobj|shape rearranged|nmod|END_ENTITY	Dynamic motion and rearranged molecular shape of heme in myoglobin : structural and functional consequences .
23758139	0	heme	83,87	myoglobin	45,54	heme	myoglobin	MESH:D006418	4151	Chemical	Gene	reconstituted|nmod|START_ENTITY reconstituted|nsubj|analysis analysis|nmod|ligand ligand|nmod|END_ENTITY	Relaxation analysis of ligand binding to the myoglobin reconstituted with cobaltic heme .
2383545	0	heme	79,83	myoglobin	58,67	heme	myoglobin	MESH:D006418	102975021	Chemical	Gene	ligation|amod|START_ENTITY effect|nmod|ligation kinetics|dep|effect kinetics|nmod|residues residues|nmod|END_ENTITY	Fluorescence decay kinetics of the tryptophyl residues of myoglobin : effect of heme ligation and evidence for discrete lifetime components .
24002046	0	heme	85,89	myoglobin	99,108	heme	myoglobin	MESH:D006418	4151	Chemical	Gene	group|amod|START_ENTITY pH-induced|nmod|group pH-induced|nmod|END_ENTITY	Electrochemical probing of the solution pH-induced structural alterations around the heme group in myoglobin .
24121340	0	heme	76,80	myoglobin	48,57	heme	myoglobin	MESH:D006418	4151	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|interaction interaction|nmod|END_ENTITY	Modulation of the intermolecular interaction of myoglobin by removal of the heme .
24222570	0	heme	110,114	myoglobin	8,17	heme	myoglobin	MESH:D006418	4151	Chemical	Gene	group|compound|START_ENTITY retaining|dobj|group stored|advcl|retaining ions|acl|stored ions|compound|END_ENTITY	Gaseous myoglobin ions stored at greater than 300 K. Multiply-charged myoglobin ions retaining the prosthetic heme group have been formed by electrospray , injected into a quadrupole ion trap , and stored for up to one second prior to mass analysis .
24350916	0	heme	16,20	myoglobin	33,42	heme	myoglobin	MESH:D006418	4151	Chemical	Gene	geometry|amod|START_ENTITY geometry|nmod|END_ENTITY	Dynamics in the heme geometry of myoglobin induced by the one-electron reduction .
25280951	0	heme	9,13	myoglobin	57,66	heme	myoglobin	MESH:D006418	280695(Tax:9913)	Chemical	Gene	capture|amod|START_ENTITY END_ENTITY|nmod|capture	In vitro heme and non-heme_iron capture from hemoglobin , myoglobin and ferritin by bovine_lactoferrin and implications for suppression of reactive oxygen species in vivo .
26544504	0	heme	68,72	myoglobin	97,106	heme	myoglobin	MESH:D006418	4151	Chemical	Gene	substituents|nsubj|START_ENTITY substituents|parataxis|END_ENTITY	Modulating the nitrite reductase activity of globins by varying the heme substituents : Utilizing myoglobin as a model system .
26606908	0	heme	31,35	myoglobin	49,58	heme	myoglobin	MESH:D006418	4151	Chemical	Gene	retention|amod|START_ENTITY crowders|nmod|retention effects|nmod|crowders effects|nmod|END_ENTITY	Unusual effects of crowders on heme retention in myoglobin .
26775281	0	heme	66,70	myoglobin	40,49	heme	myoglobin	MESH:D006418	4151	Chemical	Gene	center|amod|START_ENTITY END_ENTITY|nmod|center	Distinct mechanisms for DNA cleavage by myoglobin with a designed heme active center .
2916994	0	heme	79,83	myoglobin	112,121	heme	myoglobin	MESH:D006418	102975021	Chemical	Gene	preference|amod|START_ENTITY preference|nmod|END_ENTITY	Proton NMR study of the influence on iron oxidation/ligation/spin state on the heme orientational preference in myoglobin .
556670	0	heme	20,24	myoglobin	39,48	heme	myoglobin	MESH:D006418	102975021	Chemical	Gene	reactivity|amod|START_ENTITY reactivity|nmod|END_ENTITY	Structural basis of heme reactivity in myoglobin and leghemoglobin : thermal difference spectra .
6317075	0	heme	121,125	myoglobin	136,145	heme	myoglobin	MESH:D006418	102975021	Chemical	Gene	pocket|amod|START_ENTITY pocket|nmod|END_ENTITY	Proton magnetic resonance study of the influence of heme 2,4 substituents on the exchange rates of labile protons in the heme pocket of myoglobin .
6317075	0	heme	52,56	myoglobin	136,145	heme	myoglobin	MESH:D006418	102975021	Chemical	Gene	2,4|amod|START_ENTITY influence|nmod|2,4 study|nmod|influence substituents|nsubj|study substituents|nmod|pocket pocket|nmod|END_ENTITY	Proton magnetic resonance study of the influence of heme 2,4 substituents on the exchange rates of labile protons in the heme pocket of myoglobin .
6692820	0	heme	45,49	myoglobin	60,69	heme	myoglobin	MESH:D006418	102975021	Chemical	Gene	cavity|amod|START_ENTITY cavity|nmod|END_ENTITY	Identification of the titrating group in the heme cavity of myoglobin .
7161256	1	heme	68,72	myoglobin	107,116	heme	myoglobin	MESH:D006418	4151	Chemical	Gene	chains|amod|START_ENTITY Role|nmod|chains Role|nmod|oxygenation oxygenation|nmod|END_ENTITY	I. Role of the heme side chains in the oxygenation of myoglobin .
7236849	0	heme	75,79	myoglobin	90,99	heme	myoglobin	MESH:D006418	102975021	Chemical	Gene	pocket|amod|START_ENTITY pocket|nmod|END_ENTITY	Proton magnetic resonance characterization of the dynamic stability of the heme pocket in myoglobin by the exchange behavior of the labile proton of the proximal histidyl_imidazole .
7599114	0	heme	96,100	myoglobin	15,24	heme	myoglobin	MESH:D006418	102975021	Chemical	Gene	retention|nmod|START_ENTITY required|nmod|retention required|nsubjpass|D-helix D-helix|nmod|END_ENTITY	The D-helix in myoglobin and in the beta subunit of hemoglobin is required for the retention of heme .
7918393	0	heme	51,55	myoglobin	13,22	heme	myoglobin	MESH:D006418	102975021	Chemical	Gene	proteins|amod|START_ENTITY folding|nmod|proteins model|nmod|folding Stability|dep|model Stability|nmod|END_ENTITY	Stability of myoglobin : a model for the folding of heme proteins .
8075059	0	heme	101,105	myoglobin	48,57	heme	myoglobin	MESH:D006418	4151	Chemical	Gene	pocket|compound|START_ENTITY diffusion|nmod|pocket role|nmod|diffusion recombination|dep|role recombination|nmod|mutants mutants|nmod|END_ENTITY	Nitric_oxide recombination to double mutants of myoglobin : role of ligand diffusion in a fluctuating heme pocket .
8175669	0	heme	31,35	myoglobin	75,84	heme	myoglobin	MESH:D006418	100054434(Tax:9796)	Chemical	Gene	ligation|amod|START_ENTITY characterization|nmod|ligation characterization|dep|variant variant|nmod|END_ENTITY	Structural characterization of heme ligation in the His64 -- > Tyr variant of myoglobin .
8274643	1	heme	56,60	myoglobin	71,80	heme	myoglobin	MESH:D006418	4151	Chemical	Gene	pocket|amod|START_ENTITY Transitions|nmod|pocket Transitions|nmod|END_ENTITY	Transitions in the heme pocket of myoglobin .
8463211	0	heme	31,35	myoglobin	46,55	heme	myoglobin	MESH:D006418	102975021	Chemical	Gene	pocket|compound|START_ENTITY diffusion|nmod|pocket diffusion|nmod|END_ENTITY	Ligand diffusion in the distal heme pocket of myoglobin .
8504086	0	heme	193,197	myoglobin	82,91	heme	myoglobin	MESH:D006418	102975021	Chemical	Gene	pocket|amod|START_ENTITY contraction|nmod|pocket evidence|nmod|contraction determination|dep|evidence determination|nmod|cavity cavity|nmod|E7 E7|acl:relcl|point point|nsubj|END_ENTITY	Solution structure determination of the heme cavity in the E7 His -- > Val cyano-met myoglobin point mutant based on the 1H NMR detected dipolar field of the iron : evidence for contraction of the heme pocket .
8504086	0	heme	40,44	myoglobin	82,91	heme	myoglobin	MESH:D006418	102975021	Chemical	Gene	cavity|amod|START_ENTITY cavity|nmod|E7 E7|acl:relcl|point point|nsubj|END_ENTITY	Solution structure determination of the heme cavity in the E7 His -- > Val cyano-met myoglobin point mutant based on the 1H NMR detected dipolar field of the iron : evidence for contraction of the heme pocket .
8506324	0	heme	28,32	myoglobin	49,58	heme	myoglobin	MESH:D006418	4151	Chemical	Gene	pocket|compound|START_ENTITY pocket|nmod|mutants mutants|compound|END_ENTITY	Perturbations of the distal heme pocket in human myoglobin mutants probed by infrared spectroscopy of bound CO : correlation with ligand binding kinetics .
8507668	0	heme	59,63	myoglobin	94,103	heme	myoglobin	MESH:D006418	4151	Chemical	Gene	cavity|amod|START_ENTITY cavity|nmod|END_ENTITY	NMR study of the molecular and electronic structure of the heme cavity in Dolabella met-cyano myoglobin .
8791091	0	heme	29,33	myoglobin	54,63	heme	myoglobin	MESH:D006418	4151	Chemical	Gene	group|amod|START_ENTITY group|nmod|END_ENTITY	Covalent crosslinking of the heme prosthetic group to myoglobin by H2O2 : toxicological implications .
9370469	0	heme	33,37	myoglobin	48,57	heme	myoglobin	MESH:D006418	4151	Chemical	Gene	pocket|compound|START_ENTITY pocket|nmod|END_ENTITY	Pressure effects on the proximal heme pocket in myoglobin probed by Raman and near-infrared absorption spectroscopy .
9374489	0	heme	15,19	myoglobin	76,85	heme	myoglobin	MESH:D006418	4151	Chemical	Gene	hydrophobicity|amod|START_ENTITY hydrophobicity|nmod|dynamics dynamics|nmod|END_ENTITY	The effects of heme pocket hydrophobicity on the ligand binding dynamics in myoglobin as studied with leucine 29 mutants .
9858764	0	heme	45,49	myoglobin	90,99	heme	myoglobin	MESH:D006418	4151	Chemical	Gene	orientation|amod|START_ENTITY influence|nmod|orientation investigation|nmod|influence investigation|nmod|END_ENTITY	1H-NMR investigation of the influence of the heme orientation on functional properties of myoglobin .
11473111	0	heme	4,8	neuroglobin	30,41	heme	neuroglobin	MESH:D006418	64242(Tax:10090)	Chemical	Gene	environment|amod|START_ENTITY environment|nmod|END_ENTITY	The heme environment of mouse neuroglobin .
15070359	0	heme	25,29	neuroglobin	99,110	heme	neuroglobin	MESH:D006418	58157	Chemical	Gene	pocket|amod|START_ENTITY change|nmod|pocket larger|nsubj|change larger|nmod|END_ENTITY	Structural change of the heme pocket due to disulfide bridge formation is significantly larger for neuroglobin than for cytoglobin .
16586113	0	heme	4,8	neuroglobin	30,41	heme	neuroglobin	MESH:D006418	64242(Tax:10090)	Chemical	Gene	environment|amod|START_ENTITY environment|nmod|END_ENTITY	The heme environment of mouse neuroglobin : histidine imidazole plane orientations obtained from solution NMR and EPR spectroscopy as compared with X-ray crystallography .
18582010	0	heme	32,36	neuroglobin	40,51	heme	neuroglobin	MESH:D006418	58157	Chemical	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	How CO binds to hexacoordinated heme in neuroglobin protein .
22245004	0	heme	52,56	neuronal_PAS_domain_protein_2	80,109	heme	neuronal PAS domain protein 2	MESH:D006418	4862	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Effects of the bHLH domain on axial coordination of heme in the PAS-A domain of neuronal_PAS_domain_protein_2 -LRB- NPAS2 -RRB- : conversion from His119/Cys170 coordination to His119/His171 coordination .
11744064	0	heme	52,56	nitric-oxide_synthase	30,51	heme	nitric-oxide synthase	MESH:D006418	4842	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	Critical role of the neuronal nitric-oxide_synthase heme proximal side residue , Arg418 , in catalysis and electron transfer .
15122883	0	heme	65,69	nitric_oxide_synthase	43,64	heme	nitric oxide synthase	MESH:D006418	4843	Chemical	Gene	domain|compound|START_ENTITY domain|amod|END_ENTITY	Structures of the neuronal and endothelial nitric_oxide_synthase heme domain with D-nitroarginine-containing dipeptide inhibitors bound .
7499198	0	heme	116,120	nitric_oxide_synthase	140,161	heme	nitric oxide synthase	MESH:D006418	4843	Chemical	Gene	region|amod|START_ENTITY region|nmod|END_ENTITY	Characterization by electron paramagnetic resonance of the interactions of L-arginine and L-thiocitrulline with the heme cofactor region of nitric_oxide_synthase .
22308037	0	heme	7,11	peroxidase	55,65	heme	peroxidase	MESH:D006418	4224497(Tax:101510)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Distal heme pocket residues of B-type dye-decolorizing peroxidase : arginine but not aspartate is essential for peroxidase activity .
12644700	0	heme	20,24	pregnane_X_receptor	63,82	heme	pregnane X receptor	MESH:D006418	8856	Chemical	Gene	Control|nmod|START_ENTITY Control|nmod|END_ENTITY	Control of steroid , heme , and carcinogen metabolism by nuclear pregnane_X_receptor and constitutive_androstane_receptor .
22975842	0	heme	53,57	sulfite_oxidase	74,89	heme	sulfite oxidase	MESH:D006418	6821	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Effects of mutating aromatic surface residues of the heme domain of human sulfite_oxidase on its heme midpoint potential , intramolecular electron transfer , and steady-state kinetics .
3965510	0	heme	52,56	tryptophan_pyrrolase	79,99	heme	tryptophan pyrrolase	MESH:D006418	6999	Chemical	Gene	saturation|amod|START_ENTITY saturation|nmod|END_ENTITY	Sn-protoporphyrin rapidly and markedly enhances the heme saturation of hepatic tryptophan_pyrrolase .
16234411	0	heme-1	6,12	Hpr6	0,4	heme-1	Hpr6	MESH:C115190	851456(Tax:4932)	Chemical	Gene	protein|amod|START_ENTITY END_ENTITY|appos|protein	Hpr6 -LRB- heme-1 domain protein -RRB- regulates the susceptibility of cancer cells to chemotherapeutic drugs .
11479310	0	heme-NO	36,43	nitric-oxide_synthase	57,78	heme-NO	nitric-oxide synthase	null	4842	Chemical	Gene	complexes|amod|START_ENTITY complexes|nmod|END_ENTITY	Regulation of the properties of the heme-NO complexes in nitric-oxide_synthase by hydrogen bonding to the proximal cysteine .
229675	0	heme_iron	89,98	cytochrome_P-450	42,58	heme iron	cytochrome P-450	null	4051	Chemical	Gene	importance|nmod|START_ENTITY importance|nmod|END_ENTITY	The importance of the spin equilibrium in cytochrome_P-450 for the reduction rate of the heme_iron .
1772982	0	hementin	15,23	fibrinogen	29,39	hementin	fibrinogen	null	2244	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of hementin with fibrinogen and fibrin .
17879412	0	hemin	30,35	Heme_oxygenase-1	0,16	hemin	Heme oxygenase-1	MESH:D006427	24451(Tax:10116)	Chemical	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Heme_oxygenase-1 induction by hemin protects liver cells from ischemia/reperfusion injury in cirrhotic rats .
26595800	0	hemin	64,69	heme_oxygenase-1	16,32	hemin	heme oxygenase-1	MESH:D006427	24451(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|effects effects|nmod|END_ENTITY	Dual effects of heme_oxygenase-1 on astrocyte injury induced by hemin in vitro .
2529852	0	heparan_sulphate	12,28	factor_Xa	115,124	heparan sulphate	factor Xa	CHEBI:28815	2159	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of a heparan_sulphate with high affinity for antithrombin III upon inactivation of thrombin and coagulation factor_Xa .
1834236	0	heparan_sulphate	15,31	plasmin	75,82	heparan sulphate	plasmin	CHEBI:28815	280897(Tax:9913)	Chemical	Gene	Stimulation|nmod|START_ENTITY release|nsubj|Stimulation release|nmod|END_ENTITY	Stimulation of heparan_sulphate release from cultured endothelial cells by plasmin .
26577032	3	heparin	476,483	PNKP	443,447	heparin	PNKP	MESH:D006493	11284	Chemical	Gene	inhibition|nmod|START_ENTITY END_ENTITY|acl|inhibition	Furthermore , T4 PNKP inhibition by the inhibitor heparin is shown , demonstrating the potential to screen suitable inhibitor drugs for T4 PNKP .
23555655	0	heptadecane	27,38	NF-kB	79,84	heptadecane	NF-kB	MESH:C016486	81736(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|modulation modulation|nmod|END_ENTITY	Molecular study of dietary heptadecane for the anti-inflammatory modulation of NF-kB in the aged kidney .
1494302	0	heptylphysostigmine	65,84	AChE	56,60	heptylphysostigmine	AChE	MESH:C052450	43	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of human brain and RBC acetylcholinesterase -LRB- AChE -RRB- by heptylphysostigmine -LRB- HPTL -RRB- .
15030167	0	herbimycin_A	83,95	ERK	16,19	herbimycin A	ERK	MESH:C020754	5594	Chemical	Gene	induced|nmod|START_ENTITY cells|acl|induced differentiation|nmod|cells accelerates|dobj|differentiation accelerates|nsubj|Inactivation Inactivation|nmod|END_ENTITY	Inactivation of ERK accelerates erythroid differentiation of K562 cells induced by herbimycin_A and STI571 while activation of MEK1 interferes with it .
21743149	3	herbimycin_A	370,382	ERK	410,413	herbimycin A	FAK	MESH:C020754	5747	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Different concentrations of herbimycin_A -LRB- FAK inhibitor -RRB- and PD98059 -LRB- ERK inhibitor -RRB- were given to observe the influence on the growth of trophoblast cells , FAK , ERK phosphorylation , and trophoblast invasion abilities .
7499370	0	herbimycin_A	57,69	NF-kappa_B	73,83	herbimycin A	NF-kappa B	MESH:C020754	18033(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Studies into the effect of the tyrosine kinase inhibitor herbimycin_A on NF-kappa_B activation in T lymphocytes .
1472473	0	herbimycin_A	38,50	T_cell_antigen_receptor	120,143	herbimycin A	T cell antigen receptor	MESH:C020754	6962	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	The protein tyrosine kinase inhibitor herbimycin_A , but not genistein , specifically inhibits signal transduction by the T_cell_antigen_receptor .
1564963	0	herbimycin_A	105,117	bcr/abl	88,95	herbimycin A	bcr/abl	MESH:C020754	25;613	Chemical	Gene	gene|nmod|START_ENTITY gene|dep|END_ENTITY	Induction of differentiation of human leukemia cells with a structurally altered c-abl -LRB- bcr/abl -RRB- gene by herbimycin_A , an inhibitor of tyrosine kinase activity .
1564963	0	herbimycin_A	105,117	c-abl	81,86	herbimycin A	c-abl	MESH:C020754	25	Chemical	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Induction of differentiation of human leukemia cells with a structurally altered c-abl -LRB- bcr/abl -RRB- gene by herbimycin_A , an inhibitor of tyrosine kinase activity .
9413159	0	herbimycin_A	42,54	pp60c-src	14,23	herbimycin A	pp60c-src	MESH:C020754	20779(Tax:10090)	Chemical	Gene	kinase|nmod|START_ENTITY kinase|nsubj|Inhibition Inhibition|nmod|protein protein|amod|END_ENTITY	Inhibition of pp60c-src protein kinase by herbimycin_A in polyomavirus middle_tumor antigen-transformed cells .
3125030	0	heroin	94,100	Prolactin	0,9	heroin	Prolactin	MESH:D003932	5617	Chemical	Gene	addicts|compound|START_ENTITY thyrotropin_releasing_hormone|nmod|addicts END_ENTITY|advcl|thyrotropin_releasing_hormone	Prolactin and thyrotropin pituitary response to thyrotropin_releasing_hormone in young female heroin addicts .
17211650	0	heroin	23,29	inducible_nitric_oxide_synthase	51,82	heroin	inducible nitric oxide synthase	MESH:D003932	24599(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Conditioned effects of heroin on the expression of inducible_nitric_oxide_synthase in the rat are susceptible to extinction and latent inhibition .
11818169	0	heroin	15,21	prolactin	25,34	heroin	prolactin	MESH:D003932	707052(Tax:9544)	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	The effects of heroin on prolactin levels in male rhesus_monkeys : use of cumulative-dosing procedures .
7367458	0	heroin	11,17	prolactin	43,52	heroin	prolactin	MESH:D003932	5617	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|compound|END_ENTITY	Effects of heroin and naltrexone on plasma prolactin levels in man .
8570767	0	heroin	33,39	prolactin	49,58	heroin	prolactin	MESH:D003932	5617	Chemical	Gene	abusers|compound|START_ENTITY function|nmod|abusers function|dobj|responses responses|compound|END_ENTITY	Serotonin function in detoxified heroin abusers : prolactin and cortisol responses to fenfluramine challenge .
24789933	0	hesperetin_glucuronides	89,112	peroxisome_proliferator-activated_receptor_gamma	13,61	hesperetin glucuronides	peroxisome proliferator-activated receptor gamma	null	5468	Chemical	Gene	transactivation|nmod|START_ENTITY transactivation|amod|END_ENTITY	Mechanism of peroxisome_proliferator-activated_receptor_gamma -LRB- PPARy -RRB- transactivation by hesperetin_glucuronides is distinct from that by a thiazolidine-2 ,4 - dione agent .
26697692	0	hesperidin	10,20	TGF-beta1	24,33	hesperidin	TGF-beta1	MESH:D006569	59086(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of hesperidin on TGF-beta1 / Smad signaling pathway in HSC .
21772663	0	hesperidin	25,35	Th2	49,52	hesperidin	Th2	MESH:D006569	15111(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Antiasthmatic effects of hesperidin , a potential Th2 cytokine antagonist , in a mouse model of allergic_asthma .
18430059	0	hesperidin	11,21	endothelin-1	47,59	hesperidin	endothelin-1	MESH:D006569	1906	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|release release|amod|END_ENTITY	Effects of hesperidin on cyclic strain-induced endothelin-1 release in human umbilical vein endothelial cells .
20238017	0	hesperidin	10,20	inducible_nitric_oxide_synthase	38,69	hesperidin	inducible nitric oxide synthase	MESH:D006569	100008833(Tax:9986)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of hesperidin on expression of inducible_nitric_oxide_synthase in cultured rabbit retinal pigment epithelial cells .
21445621	0	hesperidin	21,31	p53	40,43	hesperidin	p53	MESH:D006569	7157	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	The citrus flavonoid hesperidin induces p53 and inhibits NF-kB activation in order to trigger apoptosis in NALM-6 cells : involvement of PPARy-dependent mechanism .
10956225	0	heteroaryl	39,49	cyclooxygenase-2	10,26	heteroaryl	cyclooxygenase-2	null	29527(Tax:10116)	Chemical	Gene	inhibitors|dep|START_ENTITY inhibitors|amod|END_ENTITY	Selective cyclooxygenase-2 inhibitors : heteroaryl modified 1,2-diarylimidazoles are potent , orally active antiinflammatory agents .
16419141	0	heteroaryl-acrylates	19,39	phenylalanine_ammonia-lyase	58,85	heteroaryl-acrylates	phenylalanine ammonia-lyase	null	5066	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	The interaction of heteroaryl-acrylates and alanines with phenylalanine_ammonia-lyase from parsley .
17193285	0	heteroaryl-alanines	41,60	histidine_ammonia_lyase	14,37	heteroaryl-alanines	histidine ammonia lyase	null	3034	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of histidine_ammonia_lyase by heteroaryl-alanines and acrylates .
18164199	0	heteroarylpiperidine	7,27	CCR2	89,93	heteroarylpiperidine	CCR2	CHEBI:48585	729230	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|compound|END_ENTITY	Potent heteroarylpiperidine and carboxyphenylpiperidine_1-alkyl-cyclopentane_carboxamide CCR2 antagonists .
20308224	0	heterocyclic_amines	24,43	CYP1A1	62,68	heterocyclic amines	CYP1A1	null	24296(Tax:10116)	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Metabolic activation of heterocyclic_amines and expression of CYP1A1 in the tongue .
9929169	0	heterocyclic_amines	14,33	N-acetyltransferase_1_and_2	92,119	heterocyclic amines	N-acetyltransferase 1 and 2	null	10	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of heterocyclic_amines by combinations of prostaglandin_H synthase-1 and -2 with N-acetyltransferase_1_and_2 .
20702378	0	heterocyclic_amines	41,60	S-9	64,67	heterocyclic amines	S-9	null	6203	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of mutagenic and carcinogenic heterocyclic_amines by S-9 from the liver of a rhesus_monkey .
1353262	0	heterocyclic_impromidine	48,72	histamine_H2-receptor	14,35	heterocyclic impromidine	histamine H2-receptor	null	100135540(Tax:10141)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Synthesis and histamine_H2-receptor activity of heterocyclic_impromidine analogues .
16216500	0	heterocyclic_quinones	45,66	CDC25C	125,131	heterocyclic quinones	CDC25C	null	995	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Synthesis and biological evaluation of novel heterocyclic_quinones as inhibitors of the dual specificity protein phosphatase CDC25C .
2331569	0	hetrazepine	31,42	PAF	43,46	hetrazepine	PAF	null	109585(Tax:10090)	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|compound|END_ENTITY	Differential inhibition by two hetrazepine PAF antagonists of acute inflammation in the mouse .
6142762	0	hexachlorobenzene	10,27	gamma-glutamyl_transpeptidase	59,88	hexachlorobenzene	gamma-glutamyl transpeptidase	MESH:D006581	116568(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|amod|END_ENTITY	Effect of hexachlorobenzene on male and female rat hepatic gamma-glutamyl_transpeptidase levels .
1864444	0	hexachlorobenzene	86,103	porphyrinogen_carboxylase	42,67	hexachlorobenzene	porphyrinogen carboxylase	MESH:D006581	29421(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nmod|effect	Studies on the active centre of rat liver porphyrinogen_carboxylase in vivo effect of hexachlorobenzene .
3595984	0	hexachlorobenzene	35,52	porphyrinogen_carboxylase	6,31	hexachlorobenzene	porphyrinogen carboxylase	MESH:D006581	29421(Tax:10116)	Chemical	Gene	rats|amod|START_ENTITY END_ENTITY|nmod|rats	Liver porphyrinogen_carboxylase in hexachlorobenzene porphyric rats .
6206866	0	hexachlorocyclohexane	46,67	gamma-glutamyl_transpeptidase	13,42	hexachlorocyclohexane	gamma-glutamyl transpeptidase	MESH:D001556	116568(Tax:10116)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of gamma-glutamyl_transpeptidase by hexachlorocyclohexane .
9838884	0	hexachlorocyclohexane	10,31	hsp26	35,40	hexachlorocyclohexane	hsp26	MESH:D001556	39075(Tax:7227)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of hexachlorocyclohexane on hsp26 expression in transgenic Drosophila_melanogaster .
6506093	0	hexachlorophene	90,105	acetylcholinesterase	53,73	hexachlorophene	acetylcholinesterase	MESH:D006582	11423(Tax:10090)	Chemical	Gene	treatment|compound|START_ENTITY END_ENTITY|nmod|treatment	Catalytic potential of field mouse Mus booduga brain acetylcholinesterase during repeated hexachlorophene treatment .
9049051	0	hexachlorophene	61,76	acetylcholinesterase	26,46	hexachlorophene	acetylcholinesterase	MESH:D006582	43	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|activities activities|amod|END_ENTITY	Cooperative inhibition of acetylcholinesterase activities by hexachlorophene in human erythrocytes .
9264326	0	hexadecylphosphocholine	102,125	phospholipase_A2	27,43	hexadecylphosphocholine	phospholipase A2	MESH:C039128	151056	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of phospholipase_A2 in human leukemia cells by the etherphospholipid analogue hexadecylphosphocholine .
24905207	2	hexafluorocyclopropane	86,108	CF2	129,132	hexafluorocyclopropane	CF2	null	537	Chemical	Gene	dissociation|nmod|START_ENTITY dissociation|nmod|END_ENTITY	dissociation of hexafluorocyclopropane and dimerization of CF2 .
22901384	0	hexahydronaphthalenes	40,61	Mcl-1	89,94	hexahydronaphthalenes	Mcl-1	null	4170	Chemical	Gene	Synthesis|nmod|START_ENTITY Synthesis|nmod|inhibitors inhibitors|nmod|END_ENTITY	Synthesis and evaluation of substituted hexahydronaphthalenes as novel inhibitors of the Mcl-1 / BimBH3 interaction .
26941288	0	hexamethylene_bisacetamide	29,55	BET	77,80	hexamethylene bisacetamide	BET	MESH:C014026	227325(Tax:10090)	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|compound|END_ENTITY	Cancer differentiation agent hexamethylene_bisacetamide was likely the first BET bromodomain inhibitor in clinical trials .
12539312	0	hexamethylene_bisacetamide	12,38	P53	42,45	hexamethylene bisacetamide	P53	MESH:C014026	7157	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	-LSB- Effects of hexamethylene_bisacetamide on P53 protein expression of MEC-1 cell line and cell differentiation -RSB- .
24742817	0	hexamethylene_diisocyanate	23,49	SOD_1	59,64	hexamethylene diisocyanate	SOD 1	MESH:C015262	6647	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Respiratory sensitizer hexamethylene_diisocyanate inhibits SOD_1 and induces ERK-dependent detoxifying and maturation pathways in dendritic-like cells .
1400881	0	hexapeptide	51,62	GH	22,24	hexapeptide	GH	null	2688	Chemical	Gene	response|nmod|START_ENTITY response|appos|END_ENTITY	Acute growth_hormone -LRB- GH -RRB- response to GH-releasing hexapeptide in humans is independent of endogenous GH-releasing hormone .
1400881	0	hexapeptide	51,62	growth_hormone	6,20	hexapeptide	growth hormone	null	2688	Chemical	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Acute growth_hormone -LRB- GH -RRB- response to GH-releasing hexapeptide in humans is independent of endogenous GH-releasing hormone .
7738479	0	hexapeptide	44,55	growth_hormone	68,82	hexapeptide	growth hormone	null	2688	Chemical	Gene	START_ENTITY|nmod|release release|amod|END_ENTITY	Central effects of growth_hormone-releasing hexapeptide -LRB- GHRP-6 -RRB- on growth_hormone release are inhibited by central somatostatin action .
7920995	0	hexapeptide	71,82	growth_hormone	14,28	hexapeptide	growth hormone	null	2688	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of growth_hormone secretion by the growth_hormone releasing hexapeptide -LRB- GHRP-6 -RRB- .
9428741	0	hexapeptide	134,145	neurotensin	158,169	hexapeptide	neurotensin	null	299757(Tax:10116)	Chemical	Gene	analogue|compound|START_ENTITY analogue|nmod|END_ENTITY	Stimulation of cell-surface urokinase-type_plasminogen_activator activity and cell migration in vascular endothelial cells by a novel hexapeptide analogue of neurotensin .
22940202	0	hexapeptide	9,20	parvalbumin_beta	47,63	hexapeptide	parvalbumin beta	null	4951	Chemical	Gene	sequences|compound|START_ENTITY sequences|nmod|END_ENTITY	Epitopic hexapeptide sequences from Baltic cod parvalbumin_beta -LRB- allergen Gad c 1 -RRB- are common in the universal proteome .
8369751	0	hexapeptides	26,38	neurotensin	44,55	hexapeptides	neurotensin	null	299757(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Pharmacokinetics of novel hexapeptides with neurotensin activity in rats .
15548532	0	hexaprenyl_diphosphate	106,128	Coq1	101,105	hexaprenyl diphosphate	Coq1	CHEBI:53047	852288(Tax:4932)	Chemical	Gene	synthase|compound|START_ENTITY synthase|amod|END_ENTITY	Genetic evidence for a multi-subunit complex in coenzyme Q biosynthesis in yeast and the role of the Coq1 hexaprenyl_diphosphate synthase .
10084578	0	hexarelin	75,84	GH	34,36	hexarelin	GH	MESH:C086184	2688	Chemical	Gene	response|nmod|START_ENTITY response|appos|END_ENTITY	Selective lack of growth_hormone -LRB- GH -RRB- response to the GH-releasing_peptide hexarelin in patients with GH-releasing hormone receptor deficiency .
10197083	14	hexarelin	1895,1904	GH	1860,1862	hexarelin	GH	MESH:C086184	2688	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	CONCLUSIONS : Increasing total fat mass results in a blunted GH response following subcutaneous hexarelin .
11888836	0	hexarelin	56,65	GH	121,123	hexarelin	GH	MESH:C086184	2688	Chemical	Gene	injections|nmod|START_ENTITY subcutaneous|dobj|injections subcutaneous|nmod|secretion secretion|compound|END_ENTITY	Impact of two or three daily subcutaneous injections of hexarelin , a synthetic growth_hormone -LRB- GH -RRB- secretagogue , on 24-h GH , prolactin , adrenocorticotropin and cortisol secretion in humans .
7673411	0	hexarelin	14,23	GH	43,45	hexarelin	GH	MESH:C086184	2688	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of hexarelin on growth_hormone -LRB- GH -RRB- secretion in patients with GH_deficiency .
7915227	1	hexarelin	154,163	GH	179,181	hexarelin	GH	MESH:C086184	443329(Tax:9940)	Chemical	Gene	peptide|appos|START_ENTITY peptide|nmod|secretion secretion|compound|END_ENTITY	The acute effect of a new GH-releasing peptide , hexarelin -LRB- 1 mg , iv -RRB- , on GH secretion and the mechanisms involved in its changes were investigated in conscious sheep .
9005975	0	hexarelin	98,107	GH	51,53	hexarelin	GH	MESH:C086184	2688	Chemical	Gene	effect|nmod|START_ENTITY autofeedback|nmod|effect autofeedback|nsubj|Mechanisms Mechanisms|acl|underlying underlying|dobj|growth_hormone growth_hormone|appos|END_ENTITY	Mechanisms underlying the negative growth_hormone -LRB- GH -RRB- autofeedback on the GH-releasing effect of hexarelin in man .
9364340	0	hexarelin	57,66	GH	36,38	hexarelin	GH	MESH:C086184	2688	Chemical	Gene	releasing|dobj|START_ENTITY END_ENTITY|xcomp|releasing	Growth_hormone release by the novel GH releasing peptide hexarelin in patients with homozygous beta-thalassemia .
9364340	0	hexarelin	57,66	Growth_hormone	0,14	hexarelin	Growth hormone	MESH:C086184	2688	Chemical	Gene	releasing|dobj|START_ENTITY GH|xcomp|releasing GH|nsubj|release release|amod|END_ENTITY	Growth_hormone release by the novel GH releasing peptide hexarelin in patients with homozygous beta-thalassemia .
9589671	0	hexarelin	39,48	Growth_hormone	0,14	hexarelin	Growth hormone	MESH:C086184	2688	Chemical	Gene	therapy|compound|START_ENTITY END_ENTITY|nmod|therapy	Growth_hormone status during long-term hexarelin therapy .
10084578	0	hexarelin	75,84	growth_hormone	18,32	hexarelin	growth hormone	MESH:C086184	2688	Chemical	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Selective lack of growth_hormone -LRB- GH -RRB- response to the GH-releasing_peptide hexarelin in patients with GH-releasing hormone receptor deficiency .
11191647	0	hexarelin	90,99	growth_hormone	44,58	hexarelin	growth hormone	MESH:C086184	81668(Tax:10116)	Chemical	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	The influence of sex and gonadectomy on the growth_hormone and corticosterone response to hexarelin in the rat .
9005975	0	hexarelin	98,107	growth_hormone	35,49	hexarelin	growth hormone	MESH:C086184	2688	Chemical	Gene	effect|nmod|START_ENTITY autofeedback|nmod|effect autofeedback|nsubj|Mechanisms Mechanisms|acl|underlying underlying|dobj|END_ENTITY	Mechanisms underlying the negative growth_hormone -LRB- GH -RRB- autofeedback on the GH-releasing effect of hexarelin in man .
9062497	0	hexarelin	31,40	growth_hormone	4,18	hexarelin	growth hormone	MESH:C086184	2688	Chemical	Gene	response|acl|START_ENTITY response|amod|END_ENTITY	The growth_hormone response to hexarelin in children : reproducibility and effect of sex steroids .
9425393	0	hexarelin	52,61	growth_hormone	19,33	hexarelin	growth hormone	MESH:C086184	2688	Chemical	Gene	releasing|dobj|START_ENTITY Interaction|acl|releasing Interaction|nmod|END_ENTITY	Interaction of the growth_hormone releasing peptide hexarelin with somatostatin .
9851578	0	hexarelin	6,15	growth_hormone	87,101	hexarelin	growth hormone	MESH:C086184	81668(Tax:10116)	Chemical	Gene	analogs|compound|START_ENTITY stimulate|nsubj|analogs stimulate|advcl|involving involving|dobj|release release|amod|END_ENTITY	Novel hexarelin analogs stimulate feeding in the rat through a mechanism not involving growth_hormone release .
12324716	0	hexarelin	107,116	interleukin-6_and_tumor_necrosis_factor-alpha	31,76	hexarelin	interleukin-6 and tumor necrosis factor-alpha	MESH:C086184	100628202;397086	Chemical	Gene	association|nmod|START_ENTITY END_ENTITY|dep|association	Effects of interleukin-1-beta , interleukin-6_and_tumor_necrosis_factor-alpha , alone or in association with hexarelin or galanin , on growth hormone gene expression and growth hormone release from pig pituitary cells .
23057315	0	hexavalent_chromium	17,36	VDAC1	40,45	hexavalent chromium	VDAC1	MESH:C074702	7416	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	-LSB- Interference of hexavalent_chromium on VDAC1 mRNA expression or ATP level and their potential association -RSB- .
19703554	0	hexavalent_chromium	15,34	thioredoxin_reductase	38,59	hexavalent chromium	thioredoxin reductase	MESH:C074702	25824	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of hexavalent_chromium on thioredoxin_reductase and peroxiredoxins in human bronchial epithelial cells .
983613	0	hexobarbital	15,27	cytochrome_P-450	43,59	hexobarbital	cytochrome P-450	MESH:D006591	25251(Tax:10116)	Chemical	Gene	The|nmod|START_ENTITY The|nmod|END_ENTITY	The binding of hexobarbital and aniline to cytochrome_P-450 of liver microsomes from control and phenobarbital-treated rats of different ages .
16234270	0	hexosamine	81,91	Id2	69,72	hexosamine	Id2	CHEBI:24586	3398	Chemical	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	Glucose induces increases in levels of the transcriptional repressor Id2 via the hexosamine pathway .
12802498	1	hexosamine	199,209	glutamine	236,245	hexosamine	TGF-beta1	CHEBI:24586	7040	Chemical	Gene	pathway|amod|START_ENTITY pathway|nmod|END_ENTITY	AIMS/HYPOTHESIS : Increased flux through the hexosamine biosynthetic pathway with glutamine : fructose-6-phosphate_aminotransferase -LRB- GFAT -RRB- as a rate-limiting enzyme has been linked to the enhanced bioactivity of the prosclerotic cytokine TGF-beta1 , a key mediator in the development of diabetic_nephropathy and possibly other diabetic_angiopathies .
416714	0	hexosamine	68,78	sulfatase	79,88	hexosamine	sulfatase	CHEBI:24586	347527	Chemical	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Morquio-like_syndrome with beta_galactosidase_deficiency and normal hexosamine sulfatase activity : mucopolysacchariodosis IVB .
7619085	0	hexose	10,16	GLUT5	4,9	hexose	GLUT5	CHEBI:18133	6518	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	The GLUT5 hexose transporter is also localized to the basolateral membrane of the human jejunum .
18477702	0	hexose	36,42	GLUT7	0,5	hexose	GLUT7	CHEBI:18133	155184	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|dep|transporter	GLUT7 : a new intestinal facilitated hexose transporter .
19176349	0	hexose	35,41	GLUT8	0,5	hexose	GLUT8	CHEBI:18133	56017(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|appos|transporter	GLUT8 , the enigmatic intracellular hexose transporter .
20214823	0	hexose	24,30	HXT1	10,14	hexose	HXT1	CHEBI:18133	856494(Tax:4932)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of HXT1 and HXT7 hexose transporter overexpression on wild-type and lactic_acid producing Saccharomyces_cerevisiae cells .
17520177	0	hexose	77,83	HXT7	97,101	hexose	HXT7	CHEBI:18133	851943(Tax:4932)	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Cell growth restoration and high level protein expression by the promoter of hexose transporter , HXT7 , from Saccharomyces_cerevisiae .
10191260	0	hexose	76,82	Hxt2	71,75	hexose	Hxt2	CHEBI:18133	855023(Tax:4932)	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	Functional expression , quantification and cellular localization of the Hxt2 hexose transporter of Saccharomyces_cerevisiae tagged with the green fluorescent protein .
11561293	0	hexose	50,56	Hxt7	31,35	hexose	Hxt7	CHEBI:18133	851943(Tax:4932)	Chemical	Gene	START_ENTITY|nsubj|Expression Expression|nmod|high-affinity high-affinity|amod|END_ENTITY	Expression and activity of the Hxt7 high-affinity hexose transporter of Saccharomyces_cerevisiae .
21274556	0	hexose	26,32	SGLT1	47,52	hexose	SGLT1	CHEBI:18133	20537(Tax:10090)	Chemical	Gene	transporters|amod|START_ENTITY expression|nmod|transporters expression|appos|END_ENTITY	Comparative expression of hexose transporters -LRB- SGLT1 , GLUT1 , GLUT2 and GLUT5 -RRB- throughout the mouse gastrointestinal tract .
8051137	0	hexose	52,58	STP1	74,78	hexose	STP1	CHEBI:18133	837667(Tax:3702)	Chemical	Gene	cotransporter|amod|START_ENTITY cotransporter|appos|END_ENTITY	Steady-state and presteady-state kinetics of the H + / hexose cotransporter -LRB- STP1 -RRB- from Arabidopsis_thaliana expressed in Xenopus oocytes .
3882726	0	hexose	15,21	haemopoietic_cell_growth_factor	32,63	hexose	haemopoietic cell growth factor	CHEBI:18133	16187(Tax:10090)	Chemical	Gene	uptake|amod|START_ENTITY uptake|nmod|END_ENTITY	Stimulation of hexose uptake by haemopoietic_cell_growth_factor occurs in WEHI-3B myelomonocytic_leukaemia cells : a possible mechanism for loss of growth control .
2211680	0	hexose	14,20	vascular_permeability_factor	62,90	hexose	vascular permeability factor	CHEBI:18133	281572(Tax:9913)	Chemical	Gene	transport|amod|START_ENTITY Regulation|nmod|transport Regulation|nmod|END_ENTITY	Regulation of hexose transport in aortic endothelial cells by vascular_permeability_factor and tumor_necrosis_factor-alpha , but not by insulin .
22306327	0	hexose-6-phosphate	37,55	H6PD	76,80	hexose-6-phosphate	H6PD	CHEBI:47877	9563	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The R453Q and D151A polymorphisms of hexose-6-phosphate dehydrogenase gene -LRB- H6PD -RRB- influence the polycystic_ovary_syndrome -LRB- PCOS -RRB- and obesity .
3932573	0	hexose_monophosphate	58,78	6-phosphogluconolactonase	17,42	hexose monophosphate	6-phosphogluconolactonase	null	25796	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	Limiting role of 6-phosphogluconolactonase in erythrocyte hexose_monophosphate pathway metabolism .
15106879	0	hexylresorcinol	22,37	tyrosinase	92,102	hexylresorcinol	tyrosinase	MESH:D006604	7299	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nsubj|effects	Inhibitory effects of hexylresorcinol and dodecylresorcinol on mushroom -LRB- Agaricus bisporus -RRB- tyrosinase .
10490919	5	higenamine	1285,1295	IFN-gamma	1378,1387	higenamine	IFN-gamma	MESH:C012348	25712(Tax:10116)	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|nmod|END_ENTITY	Finally , higenamine inhibited the activation of nuclear factor kappaB in RAW 264.7 cells due to LPS + IFN-gamma by mobility shift assays .
10071960	0	higenamine	118,128	iNOS	65,69	higenamine	iNOS	MESH:C012348	18126(Tax:10090)	Chemical	Gene	mRNA|nmod|START_ENTITY mRNA|nsubj|END_ENTITY	Inhibition of lipopolysaccharide-induced inducible nitric_oxide -LRB- iNOS -RRB- mRNA expression and nitric_oxide production by higenamine in murine peritoneal macrophages .
7849865	0	hippuric_acid	24,37	ALDH2	56,61	hippuric acid	ALDH2	MESH:C030514	217	Chemical	Gene	START_ENTITY|nmod|genotype genotype|compound|END_ENTITY	Distribution of urinary hippuric_acid concentrations by ALDH2 genotype .
21219881	0	hippuristanol	11,24	eIF4A	42,47	hippuristanol	eIF4A	MESH:C510125	1974	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|inhibitor inhibitor|nmod|END_ENTITY	Effects of hippuristanol , an inhibitor of eIF4A , on adult_T-cell_leukemia .
22564683	0	hirsein_A	74,83	Mitf	13,17	hirsein A	Mitf	MESH:C550879	4286	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Mechanism of Mitf inhibition and morphological differentiation effects of hirsein_A on B16 melanoma cells revealed by DNA microarray .
23438282	0	hirudin	35,42	VEGF	46,50	hirudin	VEGF	MESH:D006629	83785(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effects of natural and recombinant hirudin on VEGF expression and random skin flap survival in a venous congested rat model .
2221583	0	hirudin	22,29	thrombin	55,63	hirudin	thrombin	MESH:D006629	100144442(Tax:9823)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Effect of recombinant hirudin , a specific inhibitor of thrombin , on endotoxin-induced intravascular_coagulation and acute_lung_injury in pigs .
7708874	0	hirudin	72,79	thrombin	92,100	hirudin	thrombin	MESH:D006629	100009146(Tax:9986)	Chemical	Gene	thrombosis|nmod|START_ENTITY Inhibition|nmod|thrombosis Inhibition|dep|inhibitor inhibitor|compound|END_ENTITY	Inhibition of heparin-resistant microarterial thrombosis by recombinant hirudin : a specific thrombin inhibitor .
2462442	0	histamine	54,63	Bradykinin	0,10	histamine	Bradykinin	MESH:D006632	3827	Chemical	Gene	release|amod|START_ENTITY mediated|nmod|release mediated|nsubjpass|induced induced|compound|END_ENTITY	Bradykinin induced wheal and flare is not mediated by histamine release or cyclooxygenase products .
2481386	0	histamine	25,34	Bradykinin	0,10	histamine	Bradykinin	MESH:D006632	3827	Chemical	Gene	release|amod|START_ENTITY induce|dobj|release induce|nsubj|analog analog|compound|END_ENTITY	Bradykinin analog induce histamine release from human skin mast cells .
23005594	0	histamine	88,97	CCL22	44,49	histamine	CCL22	MESH:D006632	6367	Chemical	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of macrophage-derived_chemokine -LRB- CCL22 -RRB- in atherosclerosis and regulation by histamine via the H2 receptor .
1709143	0	histamine	83,92	CD23	41,45	histamine	CD23	MESH:D006632	2208	Chemical	Gene	release|amod|START_ENTITY induces|dobj|release induces|nsubj|END_ENTITY	Affinity-purified soluble Fc_epsilon_RII / CD23 derived from RPMI-8866 cells induces histamine release from human nasal polyp mast cells through a non-IgE-mediated mechanism .
17412405	0	histamine	59,68	Connective_tissue_growth_factor	0,31	histamine	Connective tissue growth factor	MESH:D006632	1490	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	Connective_tissue_growth_factor expression is regulated by histamine in lung fibroblasts : potential role of histamine in airway remodeling .
9178880	0	histamine	39,48	EP3	70,73	histamine	EP3	MESH:D006632	19218(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|receptors receptors|compound|END_ENTITY	Mutual interactions of the presynaptic histamine H3 and prostaglandin EP3 receptors on the noradrenergic terminals in the mouse brain .
2791236	0	histamine	83,92	Endothelium-derived_relaxing_factor	0,35	histamine	Endothelium-derived relaxing factor	MESH:D006632	51327	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|END_ENTITY	Endothelium-derived_relaxing_factor and protection against contractions induced by histamine and serotonin in the human internal mammary artery and in the saphenous vein .
12757445	0	histamine	43,52	Epidermal_growth_factor_receptor	0,32	histamine	Epidermal growth factor receptor	MESH:D006632	1956	Chemical	Gene	receptor|amod|START_ENTITY END_ENTITY|nmod|receptor	Epidermal_growth_factor_receptor - but not histamine receptor - is upregulated in seasonal_allergic_rhinitis .
21705320	0	histamine	84,93	G_protein-coupled_receptor_kinase_2	109,144	histamine	G protein-coupled receptor kinase 2	MESH:D006632	156	Chemical	Gene	receptor|amod|START_ENTITY receptor|nmod|END_ENTITY	Roles of phosphorylation-dependent and - independent mechanisms in the regulation of histamine H2 receptor by G_protein-coupled_receptor_kinase_2 .
1384357	0	histamine	21,30	Gastrin	0,7	histamine	Gastrin	MESH:D006632	2520	Chemical	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	Gastrin induction of histamine release from primary cultures of canine oxyntic mucosal cells .
1714276	0	histamine	33,42	Gastrin	1,8	histamine	Gastrin	MESH:D006632	100345451(Tax:9986)	Chemical	Gene	cells|amod|START_ENTITY receptors|nmod|cells receptors|nsubj|END_ENTITY	`` Gastrin '' and `` CCK '' receptors on histamine - and somatostatin-containing cells from rabbit fundic mucosa-II .
2445018	0	histamine	49,58	Gastrin	0,7	histamine	Gastrin	MESH:D006632	25320(Tax:10116)	Chemical	Gene	secretion|compound|START_ENTITY produces|dobj|secretion produces|nsubj|END_ENTITY	Gastrin produces an immediate and dose-dependent histamine release preceding acid secretion in the totally isolated , vascularly perfused rat stomach .
5441408	0	histamine	90,99	Gastrin	0,7	histamine	Gastrin	MESH:D006632	25320(Tax:10116)	Chemical	Gene	formation|compound|START_ENTITY investigated|nmod|formation investigated|nsubj|derivatives derivatives|compound|END_ENTITY	Gastrin derivatives investigated for secretory potency and for changes in gastric mucosal histamine formation .
6205035	0	histamine	16,25	Gastrin	0,7	histamine	Gastrin	MESH:D006632	2520	Chemical	Gene	release|amod|START_ENTITY induces|dobj|release induces|nsubj|END_ENTITY	Gastrin induces histamine release from human cutaneous mast cells .
72683	0	histamine	77,86	Gastrin	0,7	histamine	Gastrin	MESH:D006632	25320(Tax:10116)	Chemical	Gene	mobilization|nmod|START_ENTITY intermediate|nmod|mobilization END_ENTITY|dep|intermediate	Gastrin : obligatory intermediate in the postprandial mobilization of gastric histamine in the rat .
8638712	0	histamine	23,32	Gastrin	0,7	histamine	Gastrin	MESH:D006632	100345451(Tax:9986)	Chemical	Gene	synthesis|amod|START_ENTITY stimulation|nmod|synthesis stimulation|compound|END_ENTITY	Gastrin stimulation of histamine synthesis in enterochromaffin-like cells from rabbit fundic mucosa .
9018759	0	histamine	19,28	Gastrin	0,7	histamine	Gastrin	MESH:D006632	445524(Tax:9823)	Chemical	Gene	release|amod|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Gastrin stimulates histamine release from the isolated pig stomach .
30277	0	histamine	77,86	H-1	50,53	histamine	H-1	MESH:D006632	3009	Chemical	Gene	antagonist|xcomp|START_ENTITY antagonist|nsubj|Inhibition Inhibition|nmod|secretion secretion|nmod|receptor receptor|compound|END_ENTITY	Inhibition of canine gastric_acid secretion by an H-1 receptor antagonist to histamine .
3425322	0	histamine	88,97	H-1	98,101	histamine	H-1	MESH:D006632	3009	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Binding of histamine-albumin conjugates to human lymphocytes : evidence for labelling of histamine H-1 but not H-2 receptors .
24862254	0	histamine	72,81	H1-receptor	82,93	histamine	H1-receptor	MESH:D006632	15465(Tax:10090)	Chemical	Gene	mice|amod|START_ENTITY mice|compound|END_ENTITY	Impaired spatial learning and reduced adult hippocampal neurogenesis in histamine H1-receptor knockout mice .
16299042	0	histamine	24,33	H1R	44,47	histamine	H1R	MESH:D006632	3269	Chemical	Gene	expression|nmod|START_ENTITY receptors|nsubj|expression receptors|dobj|END_ENTITY	Selective expression of histamine receptors H1R , H2R , and H4R , but not H3R , in the human intestinal tract .
15986084	0	histamine	11,20	H1_and_H2	32,41	histamine	H1 and H2	MESH:D006632	3009;6019	Chemical	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Histamine , histamine receptors -LRB- H1_and_H2 -RRB- , and histidine_decarboxylase expression by chondrocytes of osteoarthritic cartilage : an immunohistochemical study .
1841552	0	histamine	36,45	H1_and_H2	26,35	histamine	H1 and H2	MESH:D006632	3009	Chemical	Gene	START_ENTITY|nsubj|Binding Binding|nmod|antagonists antagonists|nmod|END_ENTITY	Binding of antagonists of H1_and_H2 histamine receptors to peripheral blood lymphocytes of atopic and healthy subjects .
46921	0	histamine	58,67	H1_and_H2	19,28	histamine	H1 and H2	MESH:D006632	3009;6019	Chemical	Gene	release|compound|START_ENTITY antihistamines|dobj|release antihistamines|nsubj|effects effects|nmod|END_ENTITY	The effects of the H1_and_H2 antihistamines on `` allergic '' histamine release and its inhibition by histamine .
6219840	0	histamine	97,106	H1_and_H2	121,130	histamine	H1 and H2	MESH:D006632	3009;6019	Chemical	Gene	agonists|amod|START_ENTITY agonists|amod|END_ENTITY	Inhibition of phytohaemagglutinin-induced proliferation of human peripheral blood lymphocytes by histamine and histamine H1_and_H2 agonists .
7141719	0	histamine	10,19	H1_and_H2	21,30	histamine	H1 and H2	MESH:D006632	3009;6019	Chemical	Gene	agonists|amod|START_ENTITY agonists|amod|END_ENTITY	Effect of histamine , H1_and_H2 agonists on E-rosette formation in normal and atopic subjects .
19063949	0	histamine	57,66	H1_and_H2_receptor_knock-out	67,95	histamine	H1 and H2 receptor knock-out	MESH:D006632	109740(Tax:10090)	Chemical	Gene	mice|amod|START_ENTITY mice|compound|END_ENTITY	Histamine responses of large neostriatal interneurons in histamine H1_and_H2_receptor_knock-out mice .
3680788	0	histamine	11,20	H1_and_H2_receptors	65,84	histamine	H1 and H2 receptors	MESH:D006632	3009	Chemical	Gene	Effects|nmod|START_ENTITY Effects|dep|role role|nmod|END_ENTITY	Effects of histamine on coronary hemodynamics in humans : role of H1_and_H2_receptors .
9724083	0	histamine	9,18	H1_and_H2_receptors	139,158	histamine	H1 and H2 receptors	MESH:D006632	3009	Chemical	Gene	START_ENTITY|dep|importance importance|nmod|END_ENTITY	Neuronal histamine and expression of corticotropin-releasing_hormone , vasopressin and oxytocin in the hypothalamus : relative importance of H1_and_H2_receptors .
21336576	0	histamine	39,48	H1_and_muscarinic_M3	49,69	histamine	H1 and muscarinic M3	MESH:D006632	3009	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Association of genetic variants of the histamine H1_and_muscarinic_M3 receptors with BMI and HbA1c values in patients on antipsychotic medication .
18498711	0	histamine	19,28	H1_receptor	87,98	histamine	H1 receptor	MESH:D006632	3269	Chemical	Gene	H1_receptors|amod|START_ENTITY Down-regulation|nmod|H1_receptors Down-regulation|nmod|transcription transcription|amod|END_ENTITY	Down-regulation of histamine H1_receptors by beta2-adrenoceptor-mediated inhibition of H1_receptor gene transcription .
20112007	0	histamine	27,36	H1_receptor	67,78	histamine	H1 receptor	MESH:D006632	3269	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|transcription transcription|amod|END_ENTITY	Interleukin-4 up-regulates histamine H1_receptors by activation of H1_receptor gene transcription .
22897580	0	histamine	14,23	H1_receptor	58,69	histamine	H1 receptor	MESH:D006632	15465(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY Advantages|nmod|receptor antagonist|nsubj|Advantages antagonist|nmod|antagonist antagonist|amod|END_ENTITY	Advantages of histamine H4 receptor antagonist usage with H1_receptor antagonist for the treatment of murine allergic_contact_dermatitis .
25264935	0	histamine	81,90	H1_receptor	91,102	histamine	H1 receptor	MESH:D006632	24448(Tax:10116)	Chemical	Gene	agonist|amod|START_ENTITY agonist|amod|END_ENTITY	Olanzapine-activated AMPK signaling in the dorsal vagal complex is attenuated by histamine H1_receptor agonist in female rats .
26619301	0	histamine	90,99	H1_receptor	100,111	histamine	H1 receptor	MESH:D006632	24448(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	A novel benzofuran , 4-methoxybenzofuran-5-carboxamide , from Tephrosia purpurea suppressed histamine H1_receptor gene expression through a protein kinase C - - dependent signaling pathway .
26461804	0	histamine	80,89	H2	90,92	histamine	H2	MESH:D006632	6019	Chemical	Gene	antagonism|compound|START_ENTITY antagonism|nummod|END_ENTITY	Molecular modelling studies on 2-substituted_octahydropyrazinopyridoindoles for histamine H2 receptor antagonism .
20191855	0	histamine	40,49	H2R	137,140	histamine	H2R	MESH:D006632	25461(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY profile|nmod|receptor species|nsubj|profile species|nmod|interaction interaction|nmod|ligands ligands|compound|END_ENTITY	The expanded pharmacological profile of histamine H2 receptor -LRB- H2R -RRB- species isoforms with respect to the interaction with new squaramide H2R ligands , in the GTP-ASE assay .
20191855	0	histamine	40,49	H2R	63,66	histamine	H2R	MESH:D006632	25461(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	The expanded pharmacological profile of histamine H2 receptor -LRB- H2R -RRB- species isoforms with respect to the interaction with new squaramide H2R ligands , in the GTP-ASE assay .
26690914	0	histamine	40,49	H3R	50,53	histamine	H3R	MESH:D006632	11255	Chemical	Gene	ligands|amod|START_ENTITY ligands|compound|END_ENTITY	Chlorophenoxy_aminoalkyl derivatives as histamine H3R ligands and antiseizure agents .
12503632	0	histamine	20,29	H4	30,32	histamine	H4	MESH:D006632	59340	Chemical	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Identification of a histamine H4 receptor on human eosinophils -- role in eosinophil chemotaxis .
22189138	0	histamine	19,28	H4	29,31	histamine	H4	MESH:D006632	59340	Chemical	Gene	START_ENTITY|dobj|antagonists antagonists|nummod|END_ENTITY	Synthesis of novel histamine H4 receptor antagonists .
24903527	0	histamine	71,80	H4	81,83	histamine	H4	MESH:D006632	109814(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Molecular determinants for the high constitutive activity of the human histamine H4 receptor : functional studies on orthologues and mutants .
24530738	3	histamine	504,513	H4R	515,518	histamine	H2R	MESH:D006632	3274	Chemical	Gene	START_ENTITY|appos|agonists agonists|nummod|END_ENTITY	MAIN METHODS : Changes in reactive oxygen species -LRB- ROS -RRB- production by whole blood phagocytes after treatment with histamine , H4R agonists -LRB- 4-methylhistamine , VUF8430 -RRB- , H2R agonist -LRB- dimaprit -RRB- and their combinations with H4R antagonist -LRB- JNJ10191584 -RRB- and H2R antagonist -LRB- ranitidine -RRB- were determined using the chemiluminescence -LRB- CL -RRB- assay .
2861731	0	histamine	143,152	HGT-1	96,101	histamine	HGT-1	MESH:D006632	8034	Chemical	Gene	line|nmod|START_ENTITY line|xcomp|END_ENTITY	Selective disappearance of histamine H2-receptor activity in the human gastric_cancer cell line HGT-1 after short-term or chronic treatment by histamine or its H2-antagonists .
2861731	0	histamine	27,36	HGT-1	96,101	histamine	HGT-1	MESH:D006632	8034	Chemical	Gene	activity|amod|START_ENTITY disappearance|nmod|activity line|nsubj|disappearance line|xcomp|END_ENTITY	Selective disappearance of histamine H2-receptor activity in the human gastric_cancer cell line HGT-1 after short-term or chronic treatment by histamine or its H2-antagonists .
2872895	0	histamine	16,25	HGT-1	88,93	histamine	HGT-1	MESH:D006632	8034	Chemical	Gene	antagonists|amod|START_ENTITY Pharmacology|nmod|antagonists Pharmacology|nmod|END_ENTITY	Pharmacology of histamine H2 receptor antagonists in the human gastric_cancer cell line HGT-1 .
6094245	0	histamine	19,28	HGT-1	120,125	histamine	HGT-1	MESH:D006632	8034	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Desensitization by histamine of H2 receptor-mediated adenylate cyclase activation in the human gastric_cancer cell line HGT-1 .
6277484	0	histamine	85,94	HGT-1	71,76	histamine	HGT-1	MESH:D006632	8034	Chemical	Gene	H2-receptors|amod|START_ENTITY bearing|dobj|H2-receptors END_ENTITY|acl|bearing	Characterization of a newly established human gastric_cancer cell line HGT-1 bearing histamine H2-receptors .
6315003	0	histamine	54,63	HGT-1	115,120	histamine	HGT-1	MESH:D006632	8034	Chemical	Gene	receptors|amod|START_ENTITY inactivation|nmod|receptors inactivation|nmod|END_ENTITY	Irreversible and specific inactivation by AH_22216 of histamine H2 receptors in the human gastric_cancer cell line HGT-1 .
8393830	0	histamine	71,80	HGT-1	157,162	histamine	HGT-1	MESH:D006632	8034	Chemical	Gene	glucagon_like_peptide_1|amod|START_ENTITY glucagon_like_peptide_1|nmod|END_ENTITY	Protein kinase C inhibits cyclic adenosine_monophosphate generation by histamine and truncated glucagon_like_peptide_1 in the human gastric_cancer cell line HGT-1 .
11118334	0	histamine	54,63	HH4R	74,78	histamine	HH4R	MESH:D006632	59340	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Molecular cloning and characterization of a new human histamine receptor , HH4R .
22653292	0	histamine	47,56	HRH4	66,70	histamine	HRH4	MESH:D006632	59340	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Asthma endophenotypes and polymorphisms in the histamine receptor HRH4 gene .
12594246	0	histamine	14,23	IFN-alpha	33,42	histamine	IFN-alpha	MESH:D006632	3439	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|amod|END_ENTITY	Cutting edge : histamine inhibits IFN-alpha release from plasmacytoid dendritic cells .
9182905	0	histamine	24,33	IFN-gamma	64,73	histamine	IFN-gamma	MESH:D006632	3458	Chemical	Gene	modulation|nmod|START_ENTITY modulation|appos|END_ENTITY	Different modulation by histamine of IL-4 and interferon-gamma -LRB- IFN-gamma -RRB- release according to the phenotype of human Th0 , Th1 and Th2 clones .
11606024	0	histamine	34,43	IL-13	14,19	histamine	IL-13	MESH:D006632	16163(Tax:10090)	Chemical	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	Regulation of IL-13 production by histamine in cloned murine T helper type 2 cells .
1382745	0	histamine	19,28	IL-3	6,10	histamine	IL-3	MESH:D006632	16187(Tax:10090)	Chemical	Gene	release|amod|START_ENTITY induces|dobj|release induces|nsubj|END_ENTITY	Mouse IL-3 induces histamine release from mouse peritoneal mast cells .
2469718	0	histamine	25,34	IL-3	12,16	histamine	IL-3	MESH:D006632	3562	Chemical	Gene	release|amod|START_ENTITY induces|dobj|release induces|nsubj|END_ENTITY	Recombinant IL-3 induces histamine release from human basophils .
10228025	0	histamine	75,84	IL-4	179,183	histamine	IL-4	MESH:D006632	3565	Chemical	Gene	mediators|compound|START_ENTITY expression|nmod|mediators enhances|dobj|expression enhances|nmod|cord cord|dep|effect effect|nmod|END_ENTITY	IgE enhances Fc epsilon receptor I expression and IgE-dependent release of histamine and lipid mediators from human umbilical cord blood-derived mast cells : synergistic effect of IL-4 and IgE on human mast cell Fc epsilon receptor I expression and mediator release .
12949246	0	histamine	63,72	IL-4	0,4	histamine	IL-4	MESH:D006632	3565	Chemical	Gene	primes|xcomp|START_ENTITY primes|nsubj|END_ENTITY	IL-4 primes human endothelial cells for secondary responses to histamine .
1372188	4	histamine	688,697	IL-4	646,650	histamine	IL-2	MESH:D006632	3558	Chemical	Gene	release|compound|START_ENTITY inhibited|dobj|release inhibited|nsubj|END_ENTITY	IL-4 significantly inhibited IgE-mediated histamine release , while there was a trend for enhancement of IgE-mediated histamine release by IL-2 .
1372188	4	histamine	763,772	IL-4	646,650	histamine	IL-2	MESH:D006632	3558	Chemical	Gene	release|compound|START_ENTITY enhancement|nmod|release trend|nmod|enhancement was|nsubj|trend inhibited|advcl|was inhibited|nsubj|END_ENTITY	IL-4 significantly inhibited IgE-mediated histamine release , while there was a trend for enhancement of IgE-mediated histamine release by IL-2 .
16298365	0	histamine	19,28	IL-4	0,4	histamine	IL-4	MESH:D006632	3565	Chemical	Gene	content|amod|START_ENTITY modulates|dobj|content modulates|nsubj|END_ENTITY	IL-4 modulates the histamine content of mast cells in a mast cell/fibroblast co-culture through a Stat6 signaling pathway in fibroblasts .
18472844	0	histamine	83,92	IL-4	15,19	histamine	IL-4	MESH:D006632	16189(Tax:10090)	Chemical	Gene	release|amod|START_ENTITY inhibits|dobj|release inhibits|nsubj|interleukin-4_receptor interleukin-4_receptor|appos|END_ENTITY	Interleukin-4 -LRB- IL-4 -RRB- enhances and soluble interleukin-4_receptor -LRB- sIL-4R -RRB- inhibits histamine release from peripheral blood basophils and mast cells in vitro and in vivo .
20136622	0	histamine	49,58	IL-4	77,81	histamine	IL-4	MESH:D006632	287287(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY release|nmod|END_ENTITY	Phytoglycoprotein -LRB- 75 kDa -RRB- suppresses release of histamine and expression of IL-4 and IFN - _ gamma in BPA-treated RBL-2H3 cells .
8644511	0	histamine	41,50	IL-4	14,18	histamine	IL-4	MESH:D006632	3565	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of IL-4 and IL-5 secretion by histamine and PGE2 .
9469459	0	histamine	94,103	IL-4	27,31	histamine	IL-4	MESH:D006632	3565	Chemical	Gene	relationship|acl|START_ENTITY regulation|dep|relationship regulation|nmod|secretion secretion|compound|END_ENTITY	Differential regulation of IL-4 and IL-13 secretion by human basophils : their relationship to histamine release in mixed leukocyte cultures .
11803046	0	histamine	64,73	IL-6	47,51	histamine	IL-6	MESH:D006632	16193(Tax:10090)	Chemical	Gene	receptor|nmod|START_ENTITY receptor|compound|END_ENTITY	Inverse regulation of interleukin-6 -LRB- IL-6 -RRB- and IL-6 receptor in histamine deficient histidine_decarboxylase-knock-out mice .
12550104	0	histamine	28,37	IL-6	0,4	histamine	IL-6	MESH:D006632	3569	Chemical	Gene	release|compound|START_ENTITY enhances|dobj|release enhances|nsubj|END_ENTITY	IL-6 enhances IgE-dependent histamine release from human peripheral blood-derived cultured mast cells .
15031602	0	histamine	11,20	IL-6	119,123	histamine	IL-6	MESH:D006632	24498(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|dep|involvement involvement|nmod|END_ENTITY	Effects of histamine and the h2 receptor antagonist ranitidine on ischemia-induced acute_renal_failure : involvement of IL-6 and vascular_endothelial_growth_factor .
17904177	7	histamine	1320,1329	IL-6	1342,1346	histamine	IL-6	MESH:D006632	24498(Tax:10116)	Chemical	Gene	START_ENTITY|acl|stimulated stimulated|dobj|production production|compound|END_ENTITY	These inflammatory factors , except for histamine , stimulated IL-6 production to varying degrees , in the following order : IL-1alpha > IL-1beta > TNF-alpha > PGE -LRB- 2 -RRB- .
21930594	0	histamine	98,107	IL-6	59,63	histamine	IL-6	MESH:D006632	3569	Chemical	Gene	production|amod|START_ENTITY suppression|nmod|production regulates|nmod|suppression regulates|dobj|production production|compound|END_ENTITY	Aryl_hydrocarbon receptor negatively regulates LPS-induced IL-6 production through suppression of histamine production in macrophages .
21995333	0	histamine	28,37	IL-6	45,49	histamine	IL-6	MESH:D006632	3569	Chemical	Gene	START_ENTITY|xcomp|modify modify|dobj|expression expression|amod|END_ENTITY	Mast cell-derived TNF-a and histamine modify IL-6 and IL-8 expression and release from cutaneous_tumor cells .
7514639	0	histamine	76,85	IL-6	0,4	histamine	IL-6	MESH:D006632	24498(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY preceded|nmod|release preceded|nsubjpass|production production|compound|END_ENTITY	IL-6 production by rat peritoneal mast cells is not necessarily preceded by histamine release and can be induced by bacterial lipopolysaccharide .
1716285	0	histamine	14,23	IL-8	0,4	histamine	IL-8	MESH:D006632	3576	Chemical	Gene	release|amod|START_ENTITY inhibits|dobj|release inhibits|nsubj|END_ENTITY	IL-8 inhibits histamine release from human basophils induced by histamine-releasing factors , connective_tissue_activating_peptide_III , and IL-3 .
1054760	0	histamine	34,43	IgE	12,15	histamine	IgE	MESH:D006632	3497	Chemical	Gene	release|nmod|START_ENTITY role|nmod|release role|nmod|END_ENTITY	The role of IgE in the release of histamine from human gingival mast cells .
15180766	0	histamine	91,100	IgE	36,39	histamine	IgE	MESH:D006632	3497	Chemical	Gene	release|compound|START_ENTITY inhibits|dobj|release END_ENTITY|acl:relcl|inhibits	A bispecific antibody against human IgE and human FcgammaRII that inhibits antigen-induced histamine release by human mast cells and basophils .
1696102	4	histamine	675,684	IgE	631,634	histamine	IgE	MESH:D006632	3497	Chemical	Gene	release|amod|START_ENTITY informative|nmod|release seems|xcomp|informative seems|nsubj|level level|compound|END_ENTITY	The results show that the IgE level seems to be more informative than histamine release and that measurement of the specific IgE level is more sensitive with Allerbio allergen compared with other allergens .
1880090	0	histamine	108,117	IgE	128,131	histamine	IgE	MESH:D006632	3497	Chemical	Gene	START_ENTITY|dobj|levels levels|compound|END_ENTITY	Prediction of airway responsiveness to allergen from skin sensitivity to allergen , airway responsiveness to histamine and serum IgE levels .
77195	0	histamine	9,18	IgE	53,56	histamine	IgE	MESH:D006632	3497	Chemical	Gene	START_ENTITY|dobj|levels levels|compound|END_ENTITY	Cellular histamine release , specific and total serum IgE levels in hay fever patients and controls .
1643273	0	histamine	59,68	Insulin	0,7	histamine	Insulin	MESH:D006632	3630	Chemical	Gene	action|nmod|START_ENTITY stimulating|dobj|action antagonizes|ccomp|stimulating antagonizes|nsubj|END_ENTITY	Insulin antagonizes the phagocytosis stimulating action of histamine in Tetrahymena .
7534893	0	histamine	27,36	Interleukin-1_beta	0,18	histamine	Interleukin-1 beta	MESH:D006632	24494(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY induces|dobj|release induces|nsubj|END_ENTITY	Interleukin-1_beta induces histamine release in the rat hypothalamus in vivo .
7810664	0	histamine	36,45	Interleukin-1_beta	0,18	histamine	Interleukin-1 beta	MESH:D006632	24494(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY inhibits|dobj|secretion inhibits|nsubj|END_ENTITY	Interleukin-1_beta inhibits gastric histamine secretion and synthesis in the rat .
8473012	0	histamine	43,52	Interleukin-6	0,13	histamine	Interleukin-6	MESH:D006632	3569	Chemical	Gene	increased|nmod|START_ENTITY increased|nsubjpass|biosynthesis biosynthesis|amod|END_ENTITY	Interleukin-6 biosynthesis is increased by histamine in human B-cell and glioblastoma cell lines .
10854591	0	histamine	19,28	Leptin	0,6	histamine	Leptin	MESH:D006632	25608(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY facilitates|dobj|release facilitates|nsubj|END_ENTITY	Leptin facilitates histamine release from the hypothalamus in rats .
9556205	0	histamine	16,25	Midkine	0,7	histamine	Midkine	MESH:D006632	81517(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY induces|dobj|release induces|nsubj|END_ENTITY	Midkine induces histamine release from mast cells and the immediate cutaneous response .
6195384	0	histamine	62,71	N-5	54,57	histamine	N-5	MESH:D006632	64825(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY Studies|nmod|release Studies|nmod|mechanisms mechanisms|nmod|effect effect|nmod|END_ENTITY	Studies on the mechanisms of the inhibitory effect of N-5 ' on histamine release from rat peritoneal exudate cells .
6201639	0	histamine	18,27	N-5	10,13	histamine	N-5	MESH:D006632	64825(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY END_ENTITY|nmod|release	Effect of N-5 ' on histamine release from rat peritoneal exudate cells induced by calcium ionophore and ATP .
2424843	0	histamine	23,32	Neurotensin	0,11	histamine	Neurotensin	MESH:D006632	299757(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Neurotensin stimulates histamine release in in vivo skin ` blisters ' in rats : an effect inhibited by cromolyn or somatostatin .
6178820	0	histamine	34,43	Neurotensin	0,11	histamine	Neurotensin	MESH:D006632	299757(Tax:10116)	Chemical	Gene	secretion|compound|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Neurotensin stimulates exocytotic histamine secretion from rat mast cells and elevates plasma histamine levels .
6205239	0	histamine	23,32	Neurotensin	0,11	histamine	Neurotensin	MESH:D006632	299757(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Neurotensin stimulates histamine release from the isolated , spontaneously beating heart of rats .
648748	0	histamine	39,48	Neurotensin	0,11	histamine	Neurotensin	MESH:D006632	299757(Tax:10116)	Chemical	Gene	mediation|amod|START_ENTITY evidence|nmod|mediation hyperglycemia|dep|evidence hyperglycemia|compound|END_ENTITY	Neurotensin hyperglycemia : evidence for histamine mediation and the assessment of a possible physiologic role .
10482285	0	histamine	18,27	PAF	11,14	histamine	PAF	MESH:D006632	300795(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY Effects|nmod|expression Effects|nmod|END_ENTITY	Effects of PAF on histamine H1 receptor mRNA expression in rat trigeminal ganglia .
19625538	0	histamine	55,64	PAR-2	72,77	histamine	PAR-2	MESH:D006632	109447(Tax:10090)	Chemical	Gene	agonist|amod|START_ENTITY agonist|compound|END_ENTITY	Excitation of mouse superficial dorsal horn neurons by histamine and/or PAR-2 agonist : potential role in itch .
9155831	0	histamine	35,44	Platelet-activating_factor	0,26	histamine	Platelet-activating factor	MESH:D006632	9768	Chemical	Gene	release|amod|START_ENTITY induces|dobj|release induces|nsubj|END_ENTITY	Platelet-activating_factor induces histamine release from human skin mast cells in vivo , which is reduced by local nerve blockade .
6108034	0	histamine	23,32	Prolactin	0,9	histamine	Prolactin	MESH:D006632	5617	Chemical	Gene	responses|xcomp|START_ENTITY responses|nsubj|END_ENTITY	Prolactin responses to histamine H2 receptor antagonists .
6485704	0	histamine	67,76	Prolactin	0,9	histamine	Prolactin	MESH:D006632	396453(Tax:9031)	Chemical	Gene	stimulation|nmod|START_ENTITY secretion|dep|stimulation secretion|compound|END_ENTITY	Prolactin and growth_hormone secretion in chickens : stimulation by histamine and inhibition by gamma-aminobutyric_acid .
7847178	1	histamine	119,128	SSAO	92,96	histamine	SSAO	MESH:D006632	29473(Tax:10116)	Chemical	Gene	catabolism|nmod|START_ENTITY END_ENTITY|dobj|catabolism	SSAO -RRB- in the catabolism of histamine in the mesenteric arterial bed of the rat .
7506434	0	histamine	38,47	Somatostatin	0,12	histamine	Somatostatin	MESH:D006632	24797(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY inhibits|dobj|secretion inhibits|nsubj|END_ENTITY	Somatostatin inhibits gastrin-induced histamine secretion and synthesis in the rat .
18550011	0	histamine	41,50	Substance_P	0,11	histamine	Substance P	MESH:D006632	21333(Tax:10090)	Chemical	Gene	agonist|amod|START_ENTITY effect|nmod|agonist involved|nmod|effect involved|nsubjpass|END_ENTITY	Substance_P is involved in the effect of histamine H3 receptor agonist , Sch_50971 on nasal allergic_symptoms in mice .
7538443	0	histamine	20,29	Substance_P	0,11	histamine	Substance P	MESH:D006632	6863	Chemical	Gene	release|amod|START_ENTITY induces|dobj|release induces|nsubj|END_ENTITY	Substance_P induces histamine release from human pulmonary mast cells .
8808644	0	histamine	37,46	Substance_P	0,11	histamine	Substance P	MESH:D006632	6863	Chemical	Gene	mechanism|amod|START_ENTITY release|nmod|mechanism activates|dobj|release activates|nsubj|END_ENTITY	Substance_P activates the release of histamine from human skin mast cells through a pertussis toxin-sensitive and protein kinase C-dependent mechanism .
9070612	0	histamine	34,43	TGF-beta1	0,9	histamine	TGF-beta1	MESH:D006632	59086(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY inhibits|dobj|release inhibits|nsubj|END_ENTITY	TGF-beta1 inhibits the release of histamine and tumor_necrosis_factor-alpha from mast cells through an autocrine pathway .
2056280	7	histamine	1247,1256	TNF-alpha	1224,1233	histamine	TNF-alpha	MESH:D006632	7124	Chemical	Gene	synthesis|nmod|START_ENTITY synthesis|amod|END_ENTITY	Suppression of TNF-alpha synthesis by histamine is likely to be a transcriptional event , since histamine -LRB- 10 -LRB- -5 -RRB- M -RRB- reduced TNF-alpha mRNA levels fourfold .
9419020	0	histamine	94,103	Tumor_necrosis_factor_alpha	0,27	histamine	Tumor necrosis factor alpha	MESH:D006632	7124	Chemical	Gene	activates|advcl|START_ENTITY activates|nsubj|END_ENTITY	Tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- activates human adenoidal and cutaneous mast cells to histamine secretion .
6269873	0	histamine	10,19	VIP	55,58	histamine	VIP	MESH:D006632	7432	Chemical	Gene	peptide|amod|START_ENTITY peptide|appos|END_ENTITY	Action of histamine and vasoactive intestinal peptide -LRB- VIP -RRB- on cyclic_AMP in gastric glands isolated from human fetal stomach .
9789791	0	histamine	34,43	VIP	79,82	histamine	VIP	MESH:D006632	396323(Tax:9031)	Chemical	Gene	peptide|amod|START_ENTITY peptide|appos|END_ENTITY	A synergistic interaction between histamine and vasoactive intestinal peptide -LRB- VIP -RRB- on cyclic_AMP production in the chick pineal gland .
3996563	0	histamine	11,20	albumin	62,69	histamine	albumin	MESH:D006632	213	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Effect of histamine on dimedrol interaction with human serum albumin -RSB- .
9146938	0	histamine	67,76	alpha_2-macroglobulin	108,129	histamine	alpha 2-macroglobulin	MESH:D006632	2	Chemical	Gene	exudation|amod|START_ENTITY exudation|nmod|END_ENTITY	Topical azelastine has a 12-hour duration of action as assessed by histamine challenge-induced exudation of alpha_2-macroglobulin into human nasal airways .
9487344	0	histamine	19,28	alpha_2-macroglobulin	77,98	histamine	alpha 2-macroglobulin	MESH:D006632	2	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of inhaled histamine , methacholine and capsaicin on sputum levels of alpha_2-macroglobulin .
1453314	0	histamine	21,30	bradykinin	85,95	histamine	bradykinin	MESH:D006632	3827	Chemical	Gene	antagonists|amod|START_ENTITY Effects|nmod|antagonists Effects|nmod|END_ENTITY	Effects of selective histamine receptor antagonists on skin responses to intradermal bradykinin in healthy volunteers .
1970226	0	histamine	16,25	bradykinin	85,95	histamine	bradykinin	MESH:D006632	3827	Chemical	Gene	Contribution|nmod|START_ENTITY provoked|nsubj|Contribution provoked|nmod|END_ENTITY	Contribution of histamine and prostanoids to bronchoconstriction provoked by inhaled bradykinin in atopic_asthma .
2464345	0	histamine	13,22	bradykinin	61,71	histamine	bradykinin	MESH:D006632	3827	Chemical	Gene	Induction|nmod|START_ENTITY release|nsubj|Induction release|nmod|analogs analogs|compound|END_ENTITY	Induction of histamine release from human skin mast cells by bradykinin analogs .
8307852	0	histamine	46,55	bradykinin	30,40	histamine	bradykinin	MESH:D006632	3827	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Interactive effect of inhaled bradykinin with histamine and PGD2 in bronchial_asthma .
8846195	0	histamine	13,22	bradykinin	30,40	histamine	bradykinin	MESH:D006632	3827	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|response response|compound|END_ENTITY	Influence of histamine on the bradykinin response of canine testicular polymodal receptors in vitro .
8886862	0	histamine	20,29	bradykinin	47,57	histamine	bradykinin	MESH:D006632	3827	Chemical	Gene	contribution|nmod|START_ENTITY contribution|nmod|action action|nmod|END_ENTITY	The contribution of histamine to the action of bradykinin in the human nasal airway .
4131670	0	histamine	67,76	c-AMP	23,28	histamine	c-AMP	MESH:D006632	100216361(Tax:10141)	Chemical	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Studies on the role of c-AMP in the regulation of the anaphylactic histamine release from guinea_pig lung .
10837353	10	histamine	1537,1546	c-fos	1563,1568	histamine	c-fos	MESH:D006632	2353	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|mRNA mRNA|amod|END_ENTITY	Our findings suggest that histamine stimulates both c-fos and c-jun mRNA in a differential manner .
7632891	0	histamine	11,20	c-fos	29,34	histamine	c-fos	MESH:D006632	314322(Tax:10116)	Chemical	Gene	induces|advmod|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Endogenous histamine induces c-fos expression within paraventricular and supraoptic nuclei .
2427907	0	histamine	46,55	calmodulin	17,27	histamine	calmodulin	MESH:D006632	808	Chemical	Gene	control|nmod|START_ENTITY END_ENTITY|nmod|control	Possible role of calmodulin in the control of histamine release from human basophil leukocytes .
12144588	0	histamine	36,45	chromogranin_A	66,80	histamine	chromogranin A	MESH:D006632	1113	Chemical	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Prospective study of the ability of histamine , serotonin or serum chromogranin_A levels to identify gastric_carcinoids in patients with gastrinomas .
10743163	0	histamine	45,54	eosinophil_major_basic_protein	11,41	histamine	eosinophil major basic protein	MESH:D006632	5553	Chemical	Gene	release|amod|START_ENTITY END_ENTITY|nmod|release	-LSB- Effect of eosinophil_major_basic_protein on histamine release from nasal epithelial mast cells -RSB- .
1545849	0	histamine	43,52	erythropoietin	75,89	histamine	erythropoietin	MESH:D006632	2056	Chemical	Gene	START_ENTITY|nmod|therapy therapy|compound|END_ENTITY	Relief of pruritus and decreases in plasma histamine concentrations during erythropoietin therapy in patients with uremia .
10594403	0	histamine	88,97	gastrin	48,55	histamine	gastrin	MESH:D006632	100345451(Tax:9986)	Chemical	Gene	H2-receptors|amod|START_ENTITY G-cells|nmod|H2-receptors stimulate|nmod|G-cells stimulate|dobj|release release|compound|END_ENTITY	Nalpha-methyl_histamine and histamine stimulate gastrin release from rabbit G-cells via histamine H2-receptors .
10672910	0	histamine	102,111	gastrin	52,59	histamine	gastrin	MESH:D006632	25320(Tax:10116)	Chemical	Gene	mobilization|nmod|START_ENTITY mobilization|amod|END_ENTITY	Gastric submucosal microdialysis : a method to study gastrin - and food-evoked mobilization of ECL-cell histamine in conscious rats .
1123173	0	histamine	14,23	gastrin	69,76	histamine	gastrin	MESH:D006632	2520	Chemical	Gene	H2-receptor|amod|START_ENTITY effect|nmod|H2-receptor blockade|nsubj|effect blockade|nmod|levels levels|compound|END_ENTITY	The effect of histamine H2-receptor blockade with metiamide on serum gastrin levels in man .
1124491	0	histamine	10,19	gastrin	38,45	histamine	gastrin	MESH:D006632	2520	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of histamine on immunoreactive gastrin in gastric juice and in serum .
1386884	0	histamine	85,94	gastrin	36,43	histamine	gastrin	MESH:D006632	2520	Chemical	Gene	H2-receptors|compound|START_ENTITY Effect|nmod|H2-receptors Effect|nmod|peptides peptides|amod|END_ENTITY	Effect of short-term treatment with gastrin and related peptides on gastrointestinal histamine H2-receptors .
15746169	0	histamine	20,29	gastrin	106,113	histamine	gastrin	MESH:D006632	25320(Tax:10116)	Chemical	Gene	mobilization|amod|START_ENTITY regulates|dobj|mobilization regulates|advcl|controlling controlling|nmod|END_ENTITY	The vagus regulates histamine mobilization from rat stomach ECL cells by controlling their sensitivity to gastrin .
15935492	0	histamine	89,98	gastrin	46,53	histamine	gastrin	MESH:D006632	2520	Chemical	Gene	secretion|nmod|START_ENTITY secretion|amod|END_ENTITY	Somatostatin , misoprostol and galanin inhibit gastrin - and PACAP-stimulated secretion of histamine and pancreastatin from ECL cells by blocking specific Ca2 + channels .
1675023	0	histamine	49,58	gastrin	41,48	histamine	gastrin	MESH:D006632	25320(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Aspects Aspects|nmod|role role|nmod|prostaglandins prostaglandins|nmod|END_ENTITY	Aspects of the role of prostaglandins in gastrin histamine regulation of gastric_acid secretion .
1689449	0	histamine	12,21	gastrin	43,50	histamine	gastrin	MESH:D006632	25320(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY release|dep|bioassay bioassay|compound|END_ENTITY	Rat gastric histamine release : a sensitive gastrin bioassay .
1711780	0	histamine	43,52	gastrin	7,14	histamine	gastrin	MESH:D006632	25320(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY regulates|dobj|release regulates|nsubj|receptor receptor|appos|END_ENTITY	CCK-B -LRB- gastrin -RRB- receptor regulates gastric histamine release and acid secretion .
23337	0	histamine	33,42	gastrin	71,78	histamine	gastrin	MESH:D006632	2520	Chemical	Gene	action|amod|START_ENTITY Effects|nmod|action Effects|nmod|END_ENTITY	Effects of the H2-antagonists on histamine action and interaction with gastrin in isolated parietal cells .
2465675	0	histamine	46,55	gastrin	27,34	histamine	gastrin	MESH:D006632	25320(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY stimulated|dobj|release END_ENTITY|acl|stimulated	Ionized calcium influences gastrin stimulated histamine release and acid secretion , but not histamine stimulated acid output in the totally isolated vascularly perfused rat stomach .
2900546	0	histamine	11,20	gastrin	45,52	histamine	gastrin	MESH:D006632	25320(Tax:10116)	Chemical	Gene	H2-antagonists|amod|START_ENTITY H2-antagonists|nmod|levels levels|compound|END_ENTITY	-LSB- Effect of histamine H2-antagonists on serum gastrin levels in gastric lumen-perfused rats -RSB- .
3757724	0	histamine	10,19	gastrin	80,87	histamine	gastrin	MESH:D006632	2520	Chemical	Gene	stimulation|amod|START_ENTITY stimulation|nmod|END_ENTITY	Effect of histamine H2-receptor stimulation on bombesin - and peptone-stimulated gastrin release in man .
4037495	0	histamine	19,28	gastrin	10,17	histamine	gastrin	MESH:D006632	100685087	Chemical	Gene	serotonin|dep|START_ENTITY serotonin|compound|END_ENTITY	Effect of gastrin , histamine , serotonin , and adrenergic amines on gastroesophageal sphincter pressure in the dog .
4059585	0	histamine	12,21	gastrin	50,57	histamine	gastrin	MESH:D006632	100685087	Chemical	Gene	reduces|advmod|START_ENTITY reduces|dobj|release release|compound|END_ENTITY	Intravenous histamine reduces bombesin-stimulated gastrin release in dogs .
4161248	0	histamine	73,82	gastrin	34,41	histamine	gastrin	MESH:D006632	2520	Chemical	Gene	release|nmod|START_ENTITY effects|nmod|release effects|nmod|preparations preparations|compound|END_ENTITY	The effects of crude and purified gastrin preparations on the release of histamine from mast cells .
6320074	0	histamine	9,18	gastrin	49,56	histamine	gastrin	MESH:D006632	25320(Tax:10116)	Chemical	Gene	releasable|nsubj|START_ENTITY releasable|nmod|END_ENTITY	Neuronal histamine in the gut wall releasable by gastrin and cholecystokinin .
769156	0	histamine	10,19	gastrin	71,78	histamine	gastrin	MESH:D006632	2520	Chemical	Gene	blockade|amod|START_ENTITY Effect|nmod|blockade END_ENTITY|nsubj|Effect	Effect of histamine H2-receptor blockade on gastric emptying and serum gastrin in man .
8105512	0	histamine	7,16	gastrin	119,126	histamine	gastrin	MESH:D006632	2520	Chemical	Gene	mechanisms|amod|START_ENTITY mediators|nsubj|mechanisms mediators|nmod|END_ENTITY	In man histamine and muscarinergic mechanisms are essential mediators of acid secretion in response to synthetic human gastrin -LRB- 1-17 -RRB- .
8511502	0	histamine	117,126	gastrin	58,65	histamine	gastrin	MESH:D006632	25320(Tax:10116)	Chemical	Gene	antagonist|amod|START_ENTITY induced|nmod|antagonist induced|nsubj|Effect Effect|nmod|analogue analogue|nmod|hyperplasia hyperplasia|compound|END_ENTITY	Effect of a somatostatin analogue -LRB- SMS_201-995 -RRB- on antral gastrin cell hyperplasia and hypergastrinemia induced by a histamine H2-receptor antagonist .
8570859	5	histamine	1105,1114	gastrin	1152,1159	histamine	gastrin	MESH:D006632	25320(Tax:10116)	Chemical	Gene	START_ENTITY|acl:relcl|inhibited inhibited|nmod|antagonist antagonist|compound|END_ENTITY	Administration of gastrin-17 I -LRB- 10 micrograms/kg weight , sc -RRB- itself caused a significant increase in urinary excretion of histamine , which was inhibited by the specific gastrin receptor antagonist , L-365 ,260 .
7901783	0	histamine	19,28	growth_hormone	32,46	histamine	growth hormone	MESH:D006632	81668(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	Influence of brain histamine on growth_hormone secretion induced by alpha-2-receptor activation .
2894295	0	histamine	82,91	growth_hormone-releasing_factor	24,55	histamine	growth hormone-releasing factor	MESH:D006632	2691	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Antagonistic effects of growth_hormone-releasing_factor and somatostatin on brain histamine .
9720223	0	histamine	15,24	hepatocyte_growth_factor	42,66	histamine	hepatocyte growth factor	MESH:D006632	3082	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Stimulation by histamine of TPA-dependent hepatocyte_growth_factor production in promyelocytic_leukemia HL-60 cells .
10406649	0	histamine	5,14	histamine_H3-receptor	80,101	histamine	histamine H3-receptor	MESH:D006632	11255	Chemical	Gene	design|nmod|START_ENTITY design|nmod|antagonists antagonists|amod|END_ENTITY	From histamine to imidazolylalkyl-sulfonamides : the design of a novel series of histamine_H3-receptor antagonists .
3933141	0	histamine	22,31	histamine_N-methyltransferase	113,142	histamine	histamine N-methyltransferase	MESH:D006632	81676(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Inhibition of in vivo histamine metabolism in rats by foodborne and pharmacologic inhibitors of diamine_oxidase , histamine_N-methyltransferase , and monoamine oxidase .
11556524	0	histamine	126,135	histidine_decarboxylase	10,33	histamine	histidine decarboxylase	MESH:D006632	3067	Chemical	Gene	role|nmod|START_ENTITY expression|dep|role expression|amod|END_ENTITY	Increased histidine_decarboxylase expression during in vitro monocyte maturation ; a possible role of endogenously synthesised histamine in monocyte/macrophage differentiation .
11718724	0	histamine	64,73	histidine_decarboxylase	100,123	histamine	histidine decarboxylase	MESH:D006632	15186(Tax:10090)	Chemical	Gene	expression|compound|START_ENTITY down-regulation|nmod|expression induces|dobj|down-regulation induces|nmod|mice mice|amod|END_ENTITY	Histamine deficiency induces tissue-specific down-regulation of histamine H2 receptor expression in histidine_decarboxylase knockout mice .
12000707	0	histamine	55,64	histidine_decarboxylase	14,37	histamine	histidine decarboxylase	MESH:D006632	3067	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of histidine_decarboxylase and synthesis of histamine by human small_cell_lung_carcinoma .
12196593	0	histamine	137,146	histidine_decarboxylase	66,89	histamine	histidine decarboxylase	MESH:D006632	15186(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY evidence|nmod|role characteristics|dep|evidence characteristics|nmod|mice mice|amod|END_ENTITY	Anatomical , physiological , and pharmacological characteristics of histidine_decarboxylase knock-out mice : evidence for the role of brain histamine in behavioral and sleep-wake control .
12763012	0	histamine	17,26	histidine_decarboxylase	36,59	histamine	histidine decarboxylase	MESH:D006632	15186(Tax:10090)	Chemical	Gene	functions|nmod|START_ENTITY found|nsubj|functions found|nmod|mice mice|amod|END_ENTITY	New functions of histamine found in histidine_decarboxylase gene knockout mice .
1393780	0	histamine	144,153	histidine_decarboxylase	103,126	histamine	histidine decarboxylase	MESH:D006632	15186(Tax:10090)	Chemical	Gene	amount|nmod|START_ENTITY END_ENTITY|nmod|amount	Determination of histamine and polyamines in calcified tissues of mice : contribution of mast cells and histidine_decarboxylase to the amount of histamine in the bone .
15290335	0	histamine	84,93	histidine_decarboxylase	8,31	histamine	histidine decarboxylase	MESH:D006632	3067	Chemical	Gene	systems|amod|START_ENTITY vulnerability|dep|systems vulnerability|amod|END_ENTITY	Mammary histidine_decarboxylase vulnerability to enzyme antisense oligonucleotides : histamine and polyamine systems cross-talk .
1599447	0	histamine	15,24	histidine_decarboxylase	91,114	histamine	histidine decarboxylase	MESH:D006632	15186(Tax:10090)	Chemical	Gene	thioperamide|amod|START_ENTITY Effects|nmod|thioperamide Effects|dep|alpha-methylhistamine alpha-methylhistamine|nmod|activity activity|amod|END_ENTITY	Effects of the histamine H3 receptor ligands thioperamide and -LRB- R -RRB- - alpha-methylhistamine on histidine_decarboxylase activity of mouse brain .
16212954	0	histamine	27,36	histidine_decarboxylase	123,146	histamine	histidine decarboxylase	MESH:D006632	15186(Tax:10090)	Chemical	Gene	facilitates|compound|START_ENTITY facilitates|dep|study study|nmod|mice mice|amod|END_ENTITY	Intrathecally-administered histamine facilitates nociception through tachykinin NK1 and histamine H1 receptors : a study in histidine_decarboxylase gene knockout mice .
17072589	0	histamine	153,162	histidine_decarboxylase	56,79	histamine	histidine decarboxylase	MESH:D006632	15186(Tax:10090)	Chemical	Gene	function|nmod|START_ENTITY hypothesis|nmod|function support|dobj|hypothesis support|nsubj|effects effects|nmod|cocaine cocaine|nmod|mice mice|amod|END_ENTITY	The psychostimulant and rewarding effects of cocaine in histidine_decarboxylase knockout mice do not support the hypothesis of an inhibitory function of histamine on reward .
18452981	0	histamine	140,149	histidine_decarboxylase	115,138	histamine	histidine decarboxylase	MESH:D006632	24443(Tax:10116)	Chemical	Gene	H1|dep|START_ENTITY H1|compound|END_ENTITY	Apomorphine-induced turning behavior in 6-hydroxydopamine lesioned rats is increased by histidine and decreased by histidine_decarboxylase , histamine H1 and H2 receptor antagonists , and an H3 receptor agonist .
19596986	0	histamine	28,37	histidine_decarboxylase	151,174	histamine	histidine decarboxylase	MESH:D006632	24443(Tax:10116)	Chemical	Gene	START_ENTITY|acl|signaling signaling|nmod|suppression suppression|nmod|transcriptions transcriptions|compound|END_ENTITY	Suplatast tosilate inhibits histamine signaling by direct and indirect down-regulation of histamine H1 receptor gene expression through suppression of histidine_decarboxylase and IL-4 gene transcriptions .
19596986	0	histamine	90,99	histidine_decarboxylase	151,174	histamine	histidine decarboxylase	MESH:D006632	24443(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY down-regulation|nmod|expression signaling|nmod|down-regulation signaling|nmod|suppression suppression|nmod|transcriptions transcriptions|compound|END_ENTITY	Suplatast tosilate inhibits histamine signaling by direct and indirect down-regulation of histamine H1 receptor gene expression through suppression of histidine_decarboxylase and IL-4 gene transcriptions .
21052083	0	histamine	23,32	histidine_decarboxylase	105,128	histamine	histidine decarboxylase	MESH:D006632	15186(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|extinction extinction|acl|induced induced|nmod|withdrawal withdrawal|nmod|mice mice|amod|END_ENTITY	Ameliorating effect of histamine on impairment of cued fear extinction induced by morphine withdrawal in histidine_decarboxylase gene knockout mice .
21873469	0	histamine	83,92	histidine_decarboxylase	14,37	histamine	histidine decarboxylase	MESH:D006632	3067	Chemical	Gene	effects|nmod|START_ENTITY ablates|dobj|effects ablates|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of histidine_decarboxylase ablates the autocrine tumorigenic effects of histamine in human cholangiocarcinoma .
22547898	0	histamine	88,97	histidine_decarboxylase	23,46	histamine	histidine decarboxylase	MESH:D006632	3067	Chemical	Gene	production|amod|START_ENTITY enzyme|nmod|production limiting|dobj|enzyme rate|acl|limiting fluctuation|appos|rate fluctuation|nmod|expression expression|amod|END_ENTITY	Diurnal fluctuation in histidine_decarboxylase expression , the rate limiting enzyme for histamine production , and its disorder in neurodegenerative_diseases .
22627359	0	histamine	25,34	histidine_decarboxylase	58,81	histamine	histidine decarboxylase	MESH:D006632	15186(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY role|dep|evidence evidence|acl|clarified clarified|nmod|mice mice|amod|END_ENTITY	Pathophysiologic role of histamine : evidence clarified by histidine_decarboxylase gene knockout mice .
22940786	0	histamine	9,18	histidine_decarboxylase	55,78	histamine	histidine decarboxylase	MESH:D006632	3067	Chemical	Gene	START_ENTITY|nmod|induction induction|nmod|expression expression|amod|END_ENTITY	Enhanced histamine production through the induction of histidine_decarboxylase expression by phorbol_ester in Jurkat cells .
2452155	0	histamine	69,78	histidine_decarboxylase	21,44	histamine	histidine decarboxylase	MESH:D006632	15186(Tax:10090)	Chemical	Gene	increase|nmod|START_ENTITY increase|nmod|activity activity|amod|END_ENTITY	In vitro increase of histidine_decarboxylase activity and release of histamine by peritoneal resident cells of mast cell-deficient W/Wv mice ; possible involvement of macrophages .
26980430	0	histamine	139,148	histidine_decarboxylase	40,63	histamine	histidine decarboxylase	MESH:D006632	24443(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY affinities|nmod|receptor different|nmod|affinities potencies|amod|different suppress|nmod|potencies suppress|dobj|upregulation upregulation|nmod|expression expression|amod|END_ENTITY	Antihistamines suppress upregulation of histidine_decarboxylase gene expression with potencies different from their binding affinities for histamine H1 receptor in toluene_2 ,4 - diisocyanate-sensitized rats .
3136625	0	histamine	176,185	histidine_decarboxylase	122,145	histamine	histidine decarboxylase	MESH:D006632	100719978	Chemical	Gene	receptors|amod|START_ENTITY sensitivity|nmod|receptors effect|nmod|sensitivity depletion|dep|effect depletion|nmod|histamine histamine|nmod|guinea-pigs guinea-pigs|nmod|administration administration|nmod|alpha-fluoromethylhistidine alpha-fluoromethylhistidine|appos|inhibitor inhibitor|nmod|END_ENTITY	Long-term depletion of histamine in guinea-pigs by administration of alpha-fluoromethylhistidine , a specific inhibitor of histidine_decarboxylase ; effect on the sensitivity of histamine receptors .
3136625	0	histamine	23,32	histidine_decarboxylase	122,145	histamine	histidine decarboxylase	MESH:D006632	100719978	Chemical	Gene	START_ENTITY|nmod|guinea-pigs guinea-pigs|nmod|administration administration|nmod|alpha-fluoromethylhistidine alpha-fluoromethylhistidine|appos|inhibitor inhibitor|nmod|END_ENTITY	Long-term depletion of histamine in guinea-pigs by administration of alpha-fluoromethylhistidine , a specific inhibitor of histidine_decarboxylase ; effect on the sensitivity of histamine receptors .
3209236	0	histamine	51,60	histidine_decarboxylase	84,107	histamine	histidine decarboxylase	MESH:D006632	15186(Tax:10090)	Chemical	Gene	biosynthesis|compound|START_ENTITY glucocorticoids|nmod|biosynthesis Inhibition|nmod|glucocorticoids caused|nsubj|Inhibition caused|nmod|END_ENTITY	Inhibition by glucocorticoids of mitogen-dependent histamine biosynthesis caused by histidine_decarboxylase in cultured mouse spleen cells and peritoneal adherent cells .
3513611	0	histamine	54,63	histidine_decarboxylase	72,95	histamine	histidine decarboxylase	MESH:D006632	15186(Tax:10090)	Chemical	Gene	mediated|nmod|START_ENTITY mediated|nmod|END_ENTITY	LPS-caused secretion of corticosterone is mediated by histamine through histidine_decarboxylase .
4161301	0	histamine	101,110	histidine_decarboxylase	27,50	histamine	histidine decarboxylase	MESH:D006632	24443(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Action Action|nmod|inhibitor inhibitor|nmod|END_ENTITY	-LSB- Action of an inhibitor of histidine_decarboxylase on the liberation and reconstitution of cutaneous histamine in rats -RSB- .
6108701	0	histamine	21,30	histidine_decarboxylase	117,140	histamine	histidine decarboxylase	MESH:D006632	24443(Tax:10116)	Chemical	Gene	synthesis|compound|START_ENTITY Induction|nmod|synthesis Induction|dep|potentiation potentiation|nmod|activity activity|nmod|inhibitors inhibitors|amod|END_ENTITY	Induction of gastric histamine synthesis by H2-receptor antagonists : potentiation of their antisecretory activity by histidine_decarboxylase inhibitors .
6191521	0	histamine	37,46	histidine_decarboxylase	69,92	histamine	histidine decarboxylase	MESH:D006632	24443(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY cells|nmod|secretion Regeneration|nmod|cells Regeneration|dep|changes changes|nmod|activity activity|amod|END_ENTITY	Regeneration of rat mast cells after histamine secretion : changes in histidine_decarboxylase activity and heparin synthesis .
6641910	0	histamine	68,77	histidine_decarboxylase	34,57	histamine	histidine decarboxylase	MESH:D006632	3067	Chemical	Gene	concentrations|compound|START_ENTITY END_ENTITY|nmod|concentrations	Effect of prolonged inhibition of histidine_decarboxylase on tissue histamine concentrations .
6692368	0	histamine	15,24	histidine_decarboxylase	159,182	histamine	histidine decarboxylase	MESH:D006632	15186(Tax:10090)	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|dep|properties properties|nmod|monofluoromethylhistidine monofluoromethylhistidine|appos|inhibitor inhibitor|nmod|END_ENTITY	Involvement of histamine in growth of mouse and rat tumors : antitumoral properties of monofluoromethylhistidine , an enzyme-activated irreversible inhibitor of histidine_decarboxylase .
6855476	0	histamine	124,133	histidine_decarboxylase	75,98	histamine	histidine decarboxylase	MESH:D006632	24443(Tax:10116)	Chemical	Gene	development|nmod|START_ENTITY Effects|nmod|development Effects|appos|inhibitor inhibitor|nmod|END_ENTITY	Effects of alpha-fluoromethylhistidine -LRB- FMH -RRB- , an irreversible inhibitor of histidine_decarboxylase , on development of brain histamine and catecholamine systems in the neonatal rat .
686917	0	histamine	39,48	histidine_decarboxylase	66,89	histamine	histidine decarboxylase	MESH:D006632	24443(Tax:10116)	Chemical	Gene	formation|amod|START_ENTITY index|nmod|formation methylhistamine|nmod|index methylhistamine|nmod|inhibition inhibition|amod|END_ENTITY	Urinary methylhistamine as an index of histamine formation during histidine_decarboxylase inhibition in the rat .
7542315	0	histamine	64,73	histidine_decarboxylase	83,106	histamine	histidine decarboxylase	MESH:D006632	24443(Tax:10116)	Chemical	Gene	content|amod|START_ENTITY content|appos|activity activity|amod|END_ENTITY	Brain histaminergic system in mast cell-deficient -LRB- Ws/Ws -RRB- rats : histamine content , histidine_decarboxylase activity , and effects of -LRB- S -RRB- _ alpha-fluoromethylhistidine .
8476418	0	histamine	23,32	histidine_decarboxylase	86,109	histamine	histidine decarboxylase	MESH:D006632	15186(Tax:10090)	Chemical	Gene	synthesis|amod|START_ENTITY promotes|dobj|synthesis promotes|advcl|increasing increasing|dobj|expression expression|amod|END_ENTITY	Interleukin_3 promotes histamine synthesis in hematopoietic progenitors by increasing histidine_decarboxylase mRNA expression .
8898415	0	histamine	40,49	histidine_decarboxylase	60,83	histamine	histidine decarboxylase	MESH:D006632	24443(Tax:10116)	Chemical	Gene	Depletion|nmod|START_ENTITY increases|nsubj|Depletion increases|dobj|levels levels|amod|END_ENTITY	Depletion of enterochromaffin-like cell histamine increases histidine_decarboxylase and chromogranin_A mRNA levels in rat stomach by a gastrin-independent mechanism .
9757553	0	histamine	6,15	histidine_decarboxylase	59,82	histamine	histidine decarboxylase	MESH:D006632	15186(Tax:10090)	Chemical	Gene	measurement|compound|START_ENTITY used|nsubj|measurement used|xcomp|END_ENTITY	Novel histamine measurement by HPLC analysis used to assay histidine_decarboxylase inhibitory activity of shoyuflavones from soy sauce .
10620	0	histamine	14,23	insulin	106,113	histamine	insulin	MESH:D006632	3630	Chemical	Gene	H2-receptor|amod|START_ENTITY Effect|nmod|H2-receptor Effect|nmod|secretion secretion|nmod|infusion infusion|compound|END_ENTITY	Effect of the histamine H2-receptor antagonist , cimetidine , on gastric secretion and serum gastrin during insulin infusion in Man .
6197879	0	histamine	8,17	insulin	33,40	histamine	insulin	MESH:D006632	3630	Chemical	Gene	START_ENTITY|nmod|infusion infusion|compound|END_ENTITY	Gastric histamine release during insulin and pentagastrin infusion in patients with duodenal ulcer .
12364868	0	histamine	10,19	intercellular_adhesion_molecule-1	23,56	histamine	intercellular adhesion molecule-1	MESH:D006632	3383	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of histamine on intercellular_adhesion_molecule-1 expression and production of interferon-gamma and interleukin-12 in mixed lymphocyte reaction stimulated with interleukin-18 .
12364868	0	histamine	10,19	interferon-gamma	86,102	histamine	interferon-gamma	MESH:D006632	3458	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of histamine on intercellular_adhesion_molecule-1 expression and production of interferon-gamma and interleukin-12 in mixed lymphocyte reaction stimulated with interleukin-18 .
11367511	0	histamine	15,24	interferon_gamma	28,44	histamine	interferon gamma	MESH:D006632	15978(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	The effects of histamine on interferon_gamma production are dependent on the stimulatory signals .
3502482	0	histamine	10,19	interleukin-1	42,55	histamine	interleukin-1	MESH:D006632	3552	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|production production|amod|END_ENTITY	Effect of histamine and antihistamines on interleukin-1 production by human monocytes .
11367520	0	histamine	42,51	interleukin-10	14,28	histamine	interleukin-10	MESH:D006632	3586	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|secretion secretion|amod|END_ENTITY	Regulation of interleukin-10 secretion by histamine in TH2 cells and splenocytes .
10414441	0	histamine	87,96	interleukin-1beta	58,75	histamine	interleukin-1beta	MESH:D006632	24494(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY release|amod|END_ENTITY	Granulocyte-macrophage colony-stimulating factor enhances interleukin-1beta stimulated histamine release in the preovulatory rat ovary .
10233691	0	histamine	82,91	interleukin-3	53,66	histamine	interleukin-3	MESH:D006632	3562	Chemical	Gene	release|compound|START_ENTITY release|amod|END_ENTITY	Granulocyte-macrophage_colony-stimulating_factor and interleukin-3 cause basophil histamine release by a common pathway : downregulation by sodium .
8874655	0	histamine	24,33	interleukin-3	45,58	histamine	interleukin-3	MESH:D006632	3562	Chemical	Gene	release|compound|START_ENTITY release|nmod|END_ENTITY	Enhancement of basophil histamine release by interleukin-3 : reduced effect in atopic subjects .
25865264	0	histamine	19,28	interleukin-4	36,49	histamine	interleukin-4	MESH:D006632	3565	Chemical	Gene	release|amod|START_ENTITY release|compound|END_ENTITY	Is the analysis of histamine and/or interleukin-4 release after isocyanate challenge useful in the identification of patients with IgE-mediated isocyanate asthma ?
10888268	0	histamine	105,114	interleukin-6	16,29	histamine	interleukin-6	MESH:D006632	3569	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|Biosynthesis Biosynthesis|nmod|END_ENTITY	Biosynthesis of interleukin-6 , an autocrine growth factor for melanoma , is regulated by melanoma-derived histamine .
12406022	0	histamine	59,68	interleukin-6	84,97	histamine	interleukin-6	MESH:D006632	3569	Chemical	Gene	Inhibition|nmod|START_ENTITY enhanced|nsubjpass|Inhibition enhanced|advcl|END_ENTITY	Inhibition of human primary melanoma cell proliferation by histamine is enhanced by interleukin-6 .
15893120	0	histamine	6,15	interleukin-6	112,125	histamine	interleukin-6	MESH:D006632	3569	Chemical	Gene	Using|dobj|START_ENTITY _|csubj|Using _|advcl|treat treat|dobj|anemia_of_chronic_disease anemia_of_chronic_disease|nmod|suppression suppression|amod|END_ENTITY	Using histamine _ -LRB- H1 -RRB- antagonists , in particular atypical antipsychotics , to treat anemia_of_chronic_disease via interleukin-6 suppression .
19907186	0	histamine	54,63	interleukin-6	21,34	histamine	interleukin-6	MESH:D006632	3569	Chemical	Gene	receptors|amod|START_ENTITY stimulates|nmod|receptors stimulates|dobj|production production|amod|END_ENTITY	Histamine stimulates interleukin-6 production through histamine H1 receptors in human amnion cells .
9657254	0	histamine	85,94	interleukin-6	14,27	histamine	interleukin-6	MESH:D006632	3569	Chemical	Gene	levels|nmod|START_ENTITY levels|amod|END_ENTITY	Regulation of interleukin-6 , and macrophage colony-stimulating factor mRNA levels by histamine in stromal cell line -LRB- MC3T3-G2 / PA6 -RRB- .
2438959	0	histamine	36,45	interleukin_2	10,23	histamine	interleukin 2	MESH:D006632	3558	Chemical	Gene	release|compound|START_ENTITY Effect|nmod|release Effect|nmod|END_ENTITY	Effect of interleukin_2 on basophil histamine release .
1284190	0	histamine	15,24	lingual_lipase	81,95	histamine	lingual lipase	MESH:D006632	50682(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of histamine , pyrilamine , cimetidine , and ranitidine on secretion of lingual_lipase and amylase from rat von Ebner 's glands .
6153541	0	histamine	36,45	lymphokine	17,27	histamine	lymphokine	MESH:D006632	3558	Chemical	Gene	release|compound|START_ENTITY release|amod|END_ENTITY	Determination of lymphokine induced histamine release in vitro -LSB- proceedings -RSB- .
23005594	0	histamine	88,97	macrophage-derived_chemokine	14,42	histamine	macrophage-derived chemokine	MESH:D006632	6367	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of macrophage-derived_chemokine -LRB- CCL22 -RRB- in atherosclerosis and regulation by histamine via the H2 receptor .
15572202	0	histamine	54,63	neurotensin	24,35	histamine	neurotensin	MESH:D006632	67405(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY mediated|nmod|receptor mediated|nsubjpass|effect effect|nmod|END_ENTITY	The anorectic effect of neurotensin is mediated via a histamine H1 receptor in mice .
2581231	0	histamine	24,33	neurotensin	54,65	histamine	neurotensin	MESH:D006632	299757(Tax:10116)	Chemical	Gene	Characterization|nmod|START_ENTITY Characterization|acl|releasing releasing|dobj|effect effect|nmod|END_ENTITY	Characterization of the histamine releasing effect of neurotensin in the rat heart .
6182939	6	histamine	1058,1067	neurotensin	946,957	histamine	substance P	MESH:D006632	6863	Chemical	Gene	release|amod|START_ENTITY inhibited|dobj|release inhibited|nsubj|-LSB- -LSB-|amod|D-Arg8 D-Arg8|dep|END_ENTITY	4 -LSB- D-Arg8 -RSB- neurotensin , -LSB- D-Arg9 -RSB- neurotensin , xenopsin and the C-terminal octapeptide of substance_P _ -LRB- SP4-11 -RRB- all inhibited histamine release by substance_P , but physalaemin did not .
6207575	0	histamine	19,28	neurotensin	40,51	histamine	neurotensin	MESH:D006632	299757(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY inhibits|dobj|release inhibits|nmod|END_ENTITY	Forskolin inhibits histamine release by neurotensin in the rat perfused hind limb .
6405112	0	histamine	11,20	neurotensin	84,95	histamine	neurotensin	MESH:D006632	299757(Tax:10116)	Chemical	Gene	Release|nmod|START_ENTITY Release|nmod|administration administration|nmod|END_ENTITY	Release of histamine and adrenaline in vivo following intravenous administration of neurotensin .
6493455	0	histamine	13,22	neurotensin	63,74	histamine	neurotensin	MESH:D006632	299757(Tax:10116)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|acl|END_ENTITY	Influence of histamine and prostaglandin on desensitization to neurotensin in rat blood pressure .
7541694	0	histamine	22,31	neurotensin	113,124	histamine	neurotensin	MESH:D006632	299757(Tax:10116)	Chemical	Gene	START_ENTITY|xcomp|neurotensin neurotensin|nmod|SR_48692 SR_48692|appos|antagonist antagonist|nmod|receptor receptor|compound|END_ENTITY	Blockade of mast cell histamine secretion in response to neurotensin by SR_48692 , a nonpeptide antagonist of the neurotensin brain receptor .
66079	0	histamine	40,49	phospholipase-A	11,26	histamine	phospholipase-A	MESH:D006632	288025(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY END_ENTITY|nmod|release	Actions of phospholipase-A on mast-cell histamine release and paw oedema in the rat -LSB- proceedings -RSB- .
19400930	0	histamine	37,46	phospholipase_A2	77,93	histamine	phospholipase A2	MESH:D006632	151056	Chemical	Gene	START_ENTITY|nmod|N49 N49|nummod|END_ENTITY	Induction of mast cell accumulation , histamine release and skin_edema by N49 phospholipase_A2 .
6171522	0	histamine	22,31	phospholipase_A2	83,99	histamine	phospholipase A2	MESH:D006632	151056	Chemical	Gene	mechanisms|nmod|START_ENTITY release|nsubj|mechanisms release|dobj|role role|nmod|END_ENTITY	Control mechanisms of histamine release from human basophils in vitro : the role of phospholipase_A2 and of lipoxygenase metabolites .
6194706	0	histamine	39,48	phospholipase_A2	8,24	histamine	phospholipase A2	MESH:D006632	151056	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Role of phospholipase_A2 activation in histamine release from human basophils .
6195189	0	histamine	15,24	platelet_factor_4	63,80	histamine	platelet factor 4	MESH:D006632	5196	Chemical	Gene	Stimulation|nmod|START_ENTITY release|nsubj|Stimulation release|nmod|END_ENTITY	Stimulation of histamine release from human basophils by human platelet_factor_4 .
2845693	0	histamine	10,19	pro-opiomelanocortin	40,60	histamine	pro-opiomelanocortin	MESH:D006632	24664(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|nmod|END_ENTITY	Effect of histamine on the secretion of pro-opiomelanocortin derived peptides in rats .
10202993	0	histamine	13,22	prolactin	44,53	histamine	prolactin	MESH:D006632	24683(Tax:10116)	Chemical	Gene	plasma|nsubj|START_ENTITY plasma|dobj|levels levels|compound|END_ENTITY	Hypothalamic histamine , growth rate , plasma prolactin and growth_hormone levels in rats with long-term portacaval_anastomosis .
1654733	0	histamine	21,30	prolactin	54,63	histamine	prolactin	MESH:D006632	24683(Tax:10116)	Chemical	Gene	H3-receptor|compound|START_ENTITY Effects|nmod|H3-receptor ligands|nsubj|Effects ligands|nmod|secretion secretion|compound|END_ENTITY	Effects of selective histamine H3-receptor ligands on prolactin and growth_hormone secretion in the rat .
3604804	0	histamine	21,30	prolactin	70,79	histamine	prolactin	MESH:D006632	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	Involvement of brain histamine in basal and stress-induced release of prolactin in the rat .
401035	0	histamine	10,19	prolactin	67,76	histamine	prolactin	MESH:D006632	24683(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|participation participation|nmod|control control|nmod|secretion secretion|compound|END_ENTITY	H1 and H2 histamine receptor participation in the brain control of prolactin secretion in lactating rats .
6131028	0	histamine	14,23	prolactin	81,90	histamine	prolactin	MESH:D006632	5617	Chemical	Gene	stimulation|amod|START_ENTITY effect|nmod|stimulation effect|dep|inhibition inhibition|nmod|END_ENTITY	The effect of histamine stimulation and H2 - receptor inhibition on the pituitary prolactin and ACTH release and on cortisol secretion in human males .
6139293	0	histamine	48,57	prolactin	11,20	histamine	prolactin	MESH:D006632	24683(Tax:10116)	Chemical	Gene	hormone|nmod|START_ENTITY hormone|compound|END_ENTITY	Release of prolactin and luteinizing hormone by histamine agonists in ovariectomized , steroid-treated rats under ether anesthesia .
6276054	0	histamine	112,121	prolactin	37,46	histamine	prolactin	MESH:D006632	5617	Chemical	Gene	antagonists|amod|START_ENTITY hormone|nmod|antagonists stimulating|dobj|hormone stimulating|nsubj|Comparison Comparison|nmod|dose-responses dose-responses|nmod|END_ENTITY	Comparison between dose-responses of prolactin , thyroid stimulating hormone and growth_hormone to two different histamine H-2 receptor antagonists in normal men .
6305638	0	histamine	29,38	prolactin	66,75	histamine	prolactin	MESH:D006632	24683(Tax:10116)	Chemical	Gene	antagonists|amod|START_ENTITY effects|nmod|antagonists Comparison|nmod|effects Comparison|nmod|secretion secretion|compound|END_ENTITY	Comparison of the effects of histamine H2-receptor antagonists on prolactin secretion in the rat .
6619615	0	histamine	13,22	prolactin	62,71	histamine	prolactin	MESH:D006632	5617	Chemical	Gene	H2-receptor|amod|START_ENTITY Effect|nmod|H2-receptor Effect|nmod|secretion secretion|compound|END_ENTITY	-LSB- Effect of a histamine H2-receptor antagonist , cimetidine , on prolactin secretion in women -RSB- .
7175425	0	histamine	8,17	prolactin	48,57	histamine	prolactin	MESH:D006632	24683(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of histamine in the increased secretion of prolactin induced by ether in adult male rats .
7217824	0	histamine	11,20	prolactin	73,82	histamine	prolactin	MESH:D006632	24683(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY implants|nsubj|Effects implants|nmod|release release|nmod|END_ENTITY	Effects of histamine implants in several brain regions on the release of prolactin in conscious adult male rats .
958593	0	histamine	21,30	prolactin	49,58	histamine	prolactin	MESH:D006632	24683(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|control control|nmod|release release|compound|END_ENTITY	The possible role of histamine in the control of prolactin and gonadotropin release .
978198	0	histamine	17,26	prolactin	37,46	histamine	prolactin	MESH:D006632	24683(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Acute effects of histamine on plasma prolactin and luteininzing hormone levels in male rats .
3476674	0	histamine	64,73	prostaglandin_D2	14,30	histamine	prostaglandin D2	MESH:D006632	5730	Chemical	Gene	effect|acl|START_ENTITY effect|nmod|END_ENTITY	The effect of prostaglandin_D2 on the response of human skin to histamine .
14722328	0	histamine	154,163	proteinase-activated_receptor_2	119,150	histamine	proteinase-activated receptor 2	MESH:D006632	2150	Chemical	Gene	release|amod|START_ENTITY END_ENTITY|nmod|release	Inhibitors of tryptase as mast cell-stabilizing agents in the human airways : effects of tryptase and other agonists of proteinase-activated_receptor_2 on histamine release .
6223680	0	histamine	12,21	renin	50,55	histamine	renin	MESH:D006632	403838(Tax:9615)	Chemical	Gene	receptors|amod|START_ENTITY role|nmod|receptors role|nmod|release release|nmod|END_ENTITY	The role of histamine receptors in the release of renin .
12354575	0	histamine	71,80	somatostatin	24,36	histamine	somatostatin	MESH:D006632	20604(Tax:10090)	Chemical	Gene	release|amod|START_ENTITY effect|nmod|release effect|nmod|END_ENTITY	Antisecretory effect of somatostatin on gastric_acid via inhibition of histamine release in isolated mouse stomach .
11844224	0	histamine	15,24	stem_cell_factor	43,59	histamine	stem cell factor	MESH:D006632	403507(Tax:9615)	Chemical	Gene	release|compound|START_ENTITY release|nmod|END_ENTITY	Skin mast cell histamine release following stem_cell_factor and high-affinity immunoglobulin E receptor cross-linking in dogs with atopic_dermatitis .
10423066	0	histamine	25,34	substance_P	10,21	histamine	substance P	MESH:D006632	6863	Chemical	Gene	secretion|amod|START_ENTITY Effect|nmod|secretion Effect|nmod|END_ENTITY	Effect of substance_P on histamine secretion from gut mucosa in inflammatory_bowel_disease .
16603804	0	histamine	23,32	substance_P	8,19	histamine	substance P	MESH:D006632	21333(Tax:10090)	Chemical	Gene	H|amod|START_ENTITY END_ENTITY|nmod|H	Role of substance_P on histamine H -LRB- 3 -RRB- antagonist-induced scratching behavior in mice .
16964646	0	histamine	44,53	substance_P	14,25	histamine	substance P	MESH:D006632	6863	Chemical	Gene	release|nmod|START_ENTITY END_ENTITY|nmod|release	-LSB- Influence of substance_P on the release of histamine in the human hypertrophic_scar tissue -RSB- .
7531109	0	histamine	28,37	substance_P	58,69	histamine	substance P	MESH:D006632	6863	Chemical	Gene	release|dobj|START_ENTITY release|nmod|END_ENTITY	Do nasal mast cells release histamine on stimulation with substance_P in allergic_rhinitis ?
7679211	0	histamine	40,49	substance_P	11,22	histamine	substance P	MESH:D006632	21333(Tax:10090)	Chemical	Gene	release|amod|START_ENTITY elicit|dobj|release fragments|xcomp|elicit fragments|nsubj|END_ENTITY	C-terminal substance_P fragments elicit histamine release from a murine mast cell line .
8837963	0	histamine	50,59	substance_P	29,40	histamine	substance P	MESH:D006632	6863	Chemical	Gene	releases|xcomp|START_ENTITY releases|advmod|END_ENTITY	Exogenous but not endogenous substance_P releases histamine from isolated human skin fragments .
2120101	0	histamine	15,24	thyrotropin-releasing_hormone	65,94	histamine	thyrotropin-releasing hormone	MESH:D006632	25569(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|concentrations concentrations|nmod|END_ENTITY	The effects of histamine on the concentrations of immunoreactive thyrotropin-releasing_hormone in the stomach and hypothalamus in rats .
9638453	0	histamine	10,19	thyrotropin-releasing_hormone	23,52	histamine	thyrotropin-releasing hormone	MESH:D006632	25569(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of histamine on thyrotropin-releasing_hormone and somatostatin secretion in rat stomach .
1937930	0	histamine	10,19	tumor_necrosis_factor	23,44	histamine	tumor necrosis factor	MESH:D006632	7124	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|production production|compound|END_ENTITY	Effect of histamine on tumor_necrosis_factor production by human monocytes .
2056280	0	histamine	86,95	tumor_necrosis_factor_alpha	54,81	histamine	tumor necrosis factor alpha	MESH:D006632	7124	Chemical	Gene	receptors|amod|START_ENTITY END_ENTITY|nmod|receptors	Histamine suppresses gene expression and synthesis of tumor_necrosis_factor_alpha via histamine H2 receptors .
11724747	0	histamine	15,24	vascular_endothelial_growth_factor	28,62	histamine	vascular endothelial growth factor	MESH:D006632	83785(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Enhancement by histamine of vascular_endothelial_growth_factor production in granulation tissue via H -LRB- 2 -RRB- receptors .
11577198	0	histidine	21,30	AHK4	16,20	histidine	AHK4	CHEBI:27570	814714(Tax:3702)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The Arabidopsis AHK4 histidine kinase is a cytokinin-binding receptor that transduces cytokinin signals across the membrane .
12354925	0	histidine	139,148	AHK4	134,138	histidine	AHK4	CHEBI:27570	814714(Tax:3702)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Characterization of the ARR15 and ARR16 response regulators with special reference to the cytokinin signaling pathway mediated by the AHK4 histidine kinase in roots of Arabidopsis_thaliana .
17202180	0	histidine	5,14	AHK5	0,4	histidine	AHK5	CHEBI:27570	830938(Tax:3702)	Chemical	Gene	kinase|amod|START_ENTITY kinase|nummod|END_ENTITY	AHK5 histidine kinase regulates root elongation through an ETR1-dependent abscisic_acid and ethylene signaling pathway in Arabidopsis_thaliana .
23132142	0	histidine	52,61	AHP1	119,123	histidine	AHP1	CHEBI:27570	821705(Tax:3702)	Chemical	Gene	START_ENTITY|xcomp|bound bound|nmod|END_ENTITY	Structure-function analysis of Arabidopsis_thaliana histidine kinase AHK5 bound to its cognate phosphotransfer protein AHP1 .
8875940	0	histidine	8,17	CKI1	0,4	histidine	CKI1	CHEBI:27570	827076(Tax:3702)	Chemical	Gene	homolog|amod|START_ENTITY END_ENTITY|appos|homolog	CKI1 , a histidine kinase homolog implicated in cytokinin signal transduction .
9618540	0	histidine	22,31	COS1	0,4	histidine	COS1	CHEBI:27570	855380(Tax:4932)	Chemical	Gene	kinase|compound|START_ENTITY END_ENTITY|appos|kinase	COS1 , a two-component histidine kinase that is involved in hyphal development in the opportunistic pathogen Candida_albicans .
1928091	0	histidine	108,117	Carbonic_anhydrase_II	0,21	histidine	Carbonic anhydrase II	CHEBI:27570	760	Chemical	Gene	residue|amod|START_ENTITY mutation|nmod|residue caused|nmod|mutation caused|nsubjpass|syndrome syndrome|compound|END_ENTITY	Carbonic_anhydrase_II deficiency syndrome in a Belgian family is caused by a point mutation at an invariant histidine residue -LRB- 107_His -- Tyr -RRB- : complete structure of the normal human CA_II gene .
15096035	0	histidine	46,55	Cu-Zn_superoxide_dismutase	74,100	histidine	Cu-Zn superoxide dismutase	CHEBI:27570	281495(Tax:9913)	Chemical	Gene	residue|compound|START_ENTITY role|nmod|residue role|nmod|END_ENTITY	Catalytic and structural role of a metal-free histidine residue in bovine Cu-Zn_superoxide_dismutase .
2059079	0	histidine	49,58	Cytidine_deaminase	0,18	histidine	Cytidine deaminase	CHEBI:27570	978	Chemical	Gene	START_ENTITY|nsubj|activity activity|amod|END_ENTITY	Cytidine_deaminase activity , C_reactive_protein , histidine , and erythrocyte sedimentation rate as measures of disease activity in psoriatic_arthritis .
12509505	0	histidine	10,19	ETR1	69,73	histidine	ETR1	CHEBI:27570	842951(Tax:3702)	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|domain domain|nmod|receptor receptor|compound|END_ENTITY	Canonical histidine kinase activity of the transmitter domain of the ETR1 ethylene receptor from Arabidopsis is not required for signal transmission .
15466228	0	histidine	19,28	ETR1	92,96	histidine	ETR1	CHEBI:27570	842951(Tax:3702)	Chemical	Gene	domain|amod|START_ENTITY Requirement|nmod|domain transduction|nsubj|Requirement transduction|nmod|END_ENTITY	Requirement of the histidine kinase domain for signal transduction by the ethylene receptor ETR1 .
19825547	0	histidine	45,54	ETR1	90,94	histidine	ETR1	CHEBI:27570	842951(Tax:3702)	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Ethylene controls autophosphorylation of the histidine kinase domain in ethylene receptor ETR1 .
7569898	2	histidine	321,330	ETR1	356,360	histidine	ETR1	CHEBI:27570	842951(Tax:3702)	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	The deduced ERS protein has sequence similarity with the amino-terminal domain and putative histidine protein kinase domain of ETR1 , but it does not have a receiver domain as found in ETR1 .
10416589	0	histidine	111,120	FHIT	128,132	histidine	FHIT	CHEBI:27570	2272	Chemical	Gene	growth|nmod|START_ENTITY apoptosis|nmod|growth Induction|nmod|apoptosis triad|nsubj|Induction triad|xcomp|overexpression overexpression|dep|END_ENTITY	Induction of apoptosis and inhibition of tumorigenicity and tumor growth by adenovirus vector-mediated fragile histidine triad -LRB- FHIT -RRB- gene overexpression .
11085938	0	histidine	29,38	FHIT	15,19	histidine	FHIT	CHEBI:27570	2272	Chemical	Gene	triad|amod|START_ENTITY END_ENTITY|appos|triad	Association of FHIT -LRB- fragile histidine triad -RRB- , a candidate tumour suppressor gene , with the ubiquitin-conjugating enzyme hUBC9 .
11389064	0	histidine	17,26	FHIT	34,38	histidine	FHIT	CHEBI:27570	2272	Chemical	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Abnormal fragile histidine triad -LRB- FHIT -RRB- expression in advanced cervical_carcinoma : a poor prognostic factor .
11531281	0	histidine	14,23	FHIT	0,4	histidine	FHIT	CHEBI:27570	2272	Chemical	Gene	triad|amod|START_ENTITY END_ENTITY|appos|triad	FHIT -LRB- fragile histidine triad -RRB- gene analysis in cervical_intraepithelial_neoplasia .
11731438	0	histidine	27,36	FHIT	44,48	histidine	FHIT	CHEBI:27570	2272	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Aberrations in the fragile histidine triad -LRB- FHIT -RRB- gene in idiopathic_pulmonary_fibrosis .
15025965	0	histidine	32,41	FHIT	49,53	histidine	FHIT	CHEBI:27570	2272	Chemical	Gene	triad|compound|START_ENTITY triad|appos|END_ENTITY	-LSB- Abnormal expression of fragile histidine triad -LRB- FHIT -RRB- and Mut_S_homolog_2 -LRB- MSH2 -RRB- proteins in human sporadic_colorectal_carcinoma and their clinical significance -RSB- .
15384174	0	histidine	30,39	FHIT	52,56	histidine	FHIT	CHEBI:27570	2272	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Frequent silencing of fragile histidine triad gene -LRB- FHIT -RRB- in Burkitt 's _ lymphoma is associated with aberrant hypermethylation .
15627891	0	histidine	27,36	FHIT	43,47	histidine	FHIT	CHEBI:27570	2272	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Aberrations in the fragile histidine triad -LRB- FHIT -RRB- gene may be involved in lung_carcinogenesis in patients with chronic pulmonary_tuberculosis .
16026356	0	histidine	35,44	FHIT	52,56	histidine	FHIT	CHEBI:27570	692183(Tax:9913)	Chemical	Gene	triad|amod|START_ENTITY gene|amod|triad gene|appos|END_ENTITY	Comparative mapping of the fragile histidine triad -LRB- FHIT -RRB- gene in cattle , river_buffalo , sheep and goat by FISH and assignment to BTA22 by RH-mapping : a comparison with HSA3 .
16777001	0	histidine	23,32	FHIT	40,44	histidine	FHIT	CHEBI:27570	2272	Chemical	Gene	Expression|nmod|START_ENTITY triad|nsubj|Expression triad|xcomp|protein protein|dep|END_ENTITY	-LSB- Expression of fragile histidine triad -LRB- FHIT -RRB- protein and its significance in diagnosing classical Hodgkin_lymphoma -RSB- .
18467844	0	histidine	34,43	FHIT	51,55	histidine	FHIT	CHEBI:27570	692183(Tax:9913)	Chemical	Gene	triad|amod|START_ENTITY triad|appos|END_ENTITY	Molecular analysis of the fragile histidine triad -LRB- FHIT -RRB- tumor suppressor gene in vesical tumors of cattle with chronic enzootic hematuria -LRB- CEH -RRB- .
18618300	0	histidine	54,63	FHIT	71,75	histidine	FHIT	CHEBI:27570	2272	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Inverse correlation of aberrant expression of fragile histidine triad -LRB- FHIT -RRB- protein with cyclin_D1 protein and prognosis in Chinese patients with cholangiocarcinoma .
19498293	0	histidine	40,49	FHIT	57,61	histidine	FHIT	CHEBI:27570	2272	Chemical	Gene	cloning|nmod|START_ENTITY triad|nsubj|cloning triad|xcomp|expression expression|dep|END_ENTITY	Molecular cloning of the canine fragile histidine triad -LRB- FHIT -RRB- gene and Fhit protein expression in canine peripheral blood mononuclear cells .
21241597	0	histidine	23,32	FHIT	40,44	histidine	FHIT	CHEBI:27570	2272	Chemical	Gene	Expression|nmod|START_ENTITY triad|nsubj|Expression triad|xcomp|protein protein|dep|END_ENTITY	-LSB- Expression of fragile histidine triad -LRB- FHIT -RRB- protein and Ki-67 in transformed epithelial cells induced by Yunnan tin mine dust -RSB- .
23534718	0	histidine	22,31	FHIT	39,43	histidine	FHIT	CHEBI:27570	2272	Chemical	Gene	triad|compound|START_ENTITY triad|appos|END_ENTITY	Expression of fragile histidine triad -LRB- FHIT -RRB- and WW-domain oxidoreductase gene -LRB- WWOX -RRB- in nasopharyngeal_carcinoma .
23724516	0	histidine	38,47	FHIT	55,59	histidine	FHIT	CHEBI:27570	2272	Chemical	Gene	heterozygosity|nmod|START_ENTITY Loss|nmod|heterozygosity triad|nsubj|Loss triad|dobj|locus locus|appos|END_ENTITY	Loss of heterozygosity in the fragile histidine triad -LRB- FHIT -RRB- locus and expression analysis of FHIT protein in patients with breast_disorders .
24757411	0	histidine	8,17	FHIT	25,29	histidine	FHIT	CHEBI:27570	2272	Chemical	Gene	triad|compound|START_ENTITY triad|appos|END_ENTITY	Fragile histidine triad -LRB- FHIT -RRB- suppresses proliferation and promotes apoptosis in cholangiocarcinoma cells by blocking PI3K-Akt pathway .
9713284	0	histidine	56,65	FHIT	42,46	histidine	FHIT	CHEBI:27570	2272	Chemical	Gene	triad|amod|START_ENTITY gene|appos|triad gene|compound|END_ENTITY	Expression of abnormal transcripts of the FHIT -LRB- fragile histidine triad -RRB- gene in ovarian_carcinoma .
15182206	0	histidine	39,48	Fhit	56,60	histidine	Fhit	CHEBI:27570	2272	Chemical	Gene	triad|compound|START_ENTITY triad|appos|END_ENTITY	The mechanism of action of the fragile histidine triad , Fhit : isolation of a covalent adenylyl enzyme and chemical rescue of H96G-Fhit .
17137614	0	histidine	17,26	Fhit	34,38	histidine	Fhit	CHEBI:27570	2272	Chemical	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Abnormal fragile histidine triad -LRB- Fhit -RRB- expression in invasive cervical adenocarcinoma : association with tumor_aggressiveness .
17310323	0	histidine	56,65	Fhit	73,77	histidine	Fhit	CHEBI:27570	2272	Chemical	Gene	tumor|amod|START_ENTITY tumor|appos|END_ENTITY	Expression and simple , one-step purification of fragile histidine triad -LRB- Fhit -RRB- tumor suppressor mutant forms in Escherichia_coli and their interaction with protoporphyrin_IX .
19004824	0	histidine	23,32	Fhit	40,44	histidine	Fhit	CHEBI:27570	2272	Chemical	Gene	triad|amod|START_ENTITY triad|appos|END_ENTITY	Correlation of fragile histidine triad -LRB- Fhit -RRB- protein structural features with effector interactions and biological functions .
9708352	0	histidine	116,125	Fhit	92,96	histidine	Fhit	CHEBI:27570	2272	Chemical	Gene	triad|nsubj|START_ENTITY triad|ccomp|resistant resistant|dobj|analogues analogues|dep|P1,P3-triphosphate P1,P3-triphosphate|nmod|studies studies|nmod|END_ENTITY	Two hydrolase resistant analogues of diadenosine_5 ' ,5 '' ' - P1,P3-triphosphate for studies with Fhit , the human fragile histidine triad protein .
20211729	0	histidine	20,29	GPR4	69,73	histidine	GPR4	CHEBI:27570	2828	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	Each one of certain histidine residues in G-protein-coupled receptor GPR4 is critical for extracellular proton-induced stimulation of multiple G-protein-signaling pathways .
21036805	0	histidine	35,44	HIF-1alpha	63,73	histidine	HIF-1alpha	CHEBI:27570	3091	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Inhibitory effect of extracellular histidine on cobalt-induced HIF-1alpha expression .
19854893	0	histidine	12,21	HP0244	30,36	histidine	HP0244	CHEBI:27570	899176(Tax:85962)	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	Cytoplasmic histidine kinase -LRB- HP0244 -RRB- - regulated assembly of urease with UreI , a channel for urea and its metabolites , CO2 , NH3 , and NH4 -LRB- + -RRB- , is necessary for acid survival of Helicobacter_pylori .
22537104	0	histidine	11,20	LIMP-2	36,42	histidine	LIMP-2	CHEBI:27570	950	Chemical	Gene	residue|compound|START_ENTITY residue|nmod|END_ENTITY	A critical histidine residue within LIMP-2 mediates pH sensitive binding to its ligand b-glucocerebrosidase .
15025965	0	histidine	32,41	MSH2	76,80	histidine	MSH2	CHEBI:27570	4436	Chemical	Gene	triad|compound|START_ENTITY triad|appos|END_ENTITY	-LSB- Abnormal expression of fragile histidine triad -LRB- FHIT -RRB- and Mut_S_homolog_2 -LRB- MSH2 -RRB- proteins in human sporadic_colorectal_carcinoma and their clinical significance -RSB- .
21121676	0	histidine	31,40	NM23-H1	60,67	histidine	NM23-H1	CHEBI:27570	4830	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Mass spectrometry detection of histidine phosphorylation on NM23-H1 .
24961462	0	histidine	41,50	Nucleoside_diphosphate_kinase	0,29	histidine	Nucleoside diphosphate kinase	CHEBI:27570	129607	Chemical	Gene	kinase|compound|START_ENTITY END_ENTITY|nmod|kinase	Nucleoside_diphosphate_kinase as protein histidine kinase .
15322237	0	histidine	38,47	P-glycoprotein	0,14	histidine	P-glycoprotein	CHEBI:27570	67078(Tax:10090)	Chemical	Gene	mediates|advcl|START_ENTITY mediates|nsubj|END_ENTITY	P-glycoprotein mediates resistance to histidine kinase inhibitors .
8864848	0	histidine	10,19	RCC1	32,36	histidine	RCC1	CHEBI:27570	1104	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	Conserved histidine residues of RCC1 are essential for nucleotide exchange on Ran .
6265917	0	histidine	15,24	RNase_A	37,44	histidine	RNase A	CHEBI:27570	6035	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Orientation of histidine residues in RNase_A : neutron diffraction study .
24828819	0	histidine	27,36	Se155-4	78,85	histidine	Se155-4	CHEBI:27570	1056864(Tax:176280)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	The intrinsic cysteine and histidine residues of the anti-Salmonella antibody Se155-4 : a model for the introduction of new functions into antibody-binding sites .
24318926	10	histidine	1512,1521	Sln1p	1506,1511	histidine	Sln1p	CHEBI:27570	854659(Tax:4932)	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Skn7p can also receive signaling inputs from the Sln1p histidine kinase ; however , mutational analysis of specific histidine kinase receiver residues in Skn7p indicate that Sln1p does not play an important role in mat formation , suggesting that Skn7p primarily acts downstream of Wsc1p to regulate mat formation .
9843501	0	histidine	10,19	Sln1p	36,41	histidine	Sln1p	CHEBI:27570	854659(Tax:4932)	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	The yeast histidine protein kinase , Sln1p , mediates phosphotransfer to two response regulators , Ssk1p and Skn7p .
19424679	0	histidine	11,20	Slr1759	28,35	histidine	Slr1759	CHEBI:27570	953676(Tax:1148)	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|dobj|END_ENTITY	The hybrid histidine kinase Slr1759 of the cyanobacterium Synechocystis_sp .
9473505	0	histidine	28,37	TAT1	0,4	histidine	TAT1	CHEBI:27570	852361(Tax:4932)	Chemical	Gene	transporter|compound|START_ENTITY encodes|dobj|transporter encodes|nsubj|END_ENTITY	TAT1 encodes a low-affinity histidine transporter in Saccharomyces_cerevisiae .
23149425	0	histidine	16,25	TULA-2	0,6	histidine	TULA-2	CHEBI:27570	72828(Tax:10090)	Chemical	Gene	phosphatase|compound|START_ENTITY END_ENTITY|appos|phosphatase	TULA-2 , a novel histidine phosphatase , regulates bone remodeling by modulating osteoclast function .
23534718	0	histidine	22,31	WWOX	80,84	histidine	WWOX	CHEBI:27570	51741	Chemical	Gene	triad|compound|START_ENTITY triad|appos|END_ENTITY	Expression of fragile histidine triad -LRB- FHIT -RRB- and WW-domain oxidoreductase gene -LRB- WWOX -RRB- in nasopharyngeal_carcinoma .
7931300	0	histidine	8,17	adenosine_A2a_receptor	34,56	histidine	adenosine A2a receptor	CHEBI:27570	25369(Tax:10116)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Role of histidine residues in the adenosine_A2a_receptor ligand binding site .
38849	0	histidine	21,30	adenosine_deaminase	57,76	histidine	adenosine deaminase	CHEBI:27570	100	Chemical	Gene	residue|amod|START_ENTITY residue|nmod|END_ENTITY	Affinity labeling of histidine and lysine residue in the adenosine_deaminase substrate binding site .
9409331	0	histidine	80,89	apolipoprotein_B100	102,121	histidine	apolipoprotein B100	CHEBI:27570	338	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Copper_ions promote peroxidation of low density lipoprotein lipid by binding to histidine residues of apolipoprotein_B100 , but they are reduced at other sites on LDL .
20957682	0	histidine	10,19	autotaxin	23,32	histidine	autotaxin	CHEBI:27570	84050(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Effect of histidine on autotaxin activity in experimentally induced liver_fibrosis .
1354487	0	histidine	66,75	carbonic_anhydrase_II	107,128	histidine	carbonic anhydrase II	CHEBI:27570	760	Chemical	Gene	START_ENTITY|nmod|site site|nmod|END_ENTITY	Proton transfer roles of lysine 64 and glutamic_acid 64 replacing histidine 64 in the active site of human carbonic_anhydrase_II .
14984209	0	histidine	68,77	carbonic_anhydrase_II	14,35	histidine	carbonic anhydrase II	CHEBI:27570	760	Chemical	Gene	analogs|amod|START_ENTITY Activation|nmod|analogs Activation|nmod|END_ENTITY	Activation of carbonic_anhydrase_II by active-site incorporation of histidine analogs .
2514797	0	histidine	8,17	carbonic_anhydrase_II	57,78	histidine	carbonic anhydrase II	CHEBI:27570	760	Chemical	Gene	START_ENTITY|nmod|mechanism mechanism|nmod|END_ENTITY	Role of histidine 64 in the catalytic mechanism of human carbonic_anhydrase_II studied with a site-specific mutant .
5461620	0	histidine	25,34	carnitine_acetyltransferase	46,73	histidine	carnitine acetyltransferase	CHEBI:27570	1384	Chemical	Gene	residue|amod|START_ENTITY residue|nmod|END_ENTITY	Specific alkylation of a histidine residue in carnitine_acetyltransferase by bromoacetyl-L-carnitine .
3719856	0	histidine	29,38	cytochrome_P-450	68,84	histidine	cytochrome P-450	CHEBI:27570	25251(Tax:10116)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Chemical modification of the histidine residues of purified hepatic cytochrome_P-450 : influence on substrate binding and the haemoprotein spin state .
43839	0	histidine	43,52	cytochrome_c	78,90	histidine	cytochrome c	CHEBI:27570	104968582	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Hydrogen-tritium exchange titration of the histidine residues in bovine heart cytochrome_c and analysis of their microenvironment .
5862203	2	histidine	59,68	cytochrome_c	81,93	histidine	cytochrome c	CHEBI:27570	54205	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	Heme-linked histidine residues in cytochrome_c as determined with diazonium-1-H-tetrazole .
26069730	0	histidine	21,30	cytoglobin	72,82	histidine	cytoglobin	CHEBI:27570	114757	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	Effect of the distal histidine on the peroxidatic activity of monomeric cytoglobin .
1918058	0	histidine	8,17	glutathione_S-transferase	30,55	histidine	glutathione S-transferase	CHEBI:27570	58962(Tax:10116)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Are the histidine residues of glutathione_S-transferase important in catalysis ?
12650998	0	histidine	28,37	granulocyte-colony_stimulating_factor	68,105	histidine	granulocyte-colony stimulating factor	CHEBI:27570	1440	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	Mutation of surface-exposed histidine residues of recombinant human granulocyte-colony_stimulating_factor -LRB- Cys17Ser -RRB- impacts on interaction with chelated metal ions and refolding in aqueous two-phase systems .
17339136	0	histidine	18,27	granulocyte-colony_stimulating_factor	110,147	histidine	granulocyte-colony stimulating factor	CHEBI:27570	1440	Chemical	Gene	START_ENTITY|nmod|the the|nmod|END_ENTITY	Effect of surface histidine mutations and their number on the partitioning and refolding of recombinant human granulocyte-colony_stimulating_factor -LRB- Cys17Ser -RRB- in aqueous two-phase systems containing chelated metal ions .
9025937	0	histidine	34,43	growth_hormone	53,67	histidine	growth hormone	CHEBI:27570	2688	Chemical	Gene	photooxidation|nmod|START_ENTITY photooxidation|nmod|END_ENTITY	Metal-catalyzed photooxidation of histidine in human growth_hormone .
9083026	0	histidine	29,38	growth_hormone	48,62	histidine	growth hormone	CHEBI:27570	2688	Chemical	Gene	oxidation|nmod|START_ENTITY oxidation|nmod|END_ENTITY	Metal-catalyzed oxidation of histidine in human growth_hormone .
7681064	0	histidine	22,31	hemopexin	44,53	histidine	hemopexin	CHEBI:27570	100009541(Tax:9986)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Identification of the histidine residues of hemopexin that coordinate with heme-iron and of a receptor-binding region .
8078898	0	histidine	32,41	hemopexin	60,69	histidine	hemopexin	CHEBI:27570	3263	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	Roles of heme_iron-coordinating histidine residues of human hemopexin expressed in baculovirus-infected insect cells .
176880	1	histidine	103,112	histidine_decarboxylase	170,193	histidine	histidine decarboxylase	CHEBI:27570	3067	Chemical	Gene	phosphate|compound|START_ENTITY kinetics|nmod|phosphate kinetics|nmod|END_ENTITY	-LRB- 4 -RRB- The kinetics of complex formation between histidine and pyridoxal_5 '_- phosphate in the presence of bacterial histidine_decarboxylase .
235021	0	histidine	14,23	histidine_decarboxylase	119,142	histidine	histidine decarboxylase	CHEBI:27570	24443(Tax:10116)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|inhibitor inhibitor|nmod|END_ENTITY	Inhibition of histidine , decarboxylation in vivo by 2-hydroxy-5-carbomethoxybenzyloxyamine , a new , potent inhibitor of histidine_decarboxylase .
853508	0	histidine	77,86	histidine_decarboxylase	24,47	histidine	histidine decarboxylase	CHEBI:27570	3067	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Attempted inhibition of histidine_decarboxylase with beta-alkyl analogues of histidine .
12105213	0	histidine	80,89	kinase_suppressor_of_Ras	49,73	histidine	kinase suppressor of Ras	CHEBI:27570	8844	Chemical	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	Nm23-H1 metastasis suppressor phosphorylation of kinase_suppressor_of_Ras via a histidine protein kinase pathway .
1567851	0	histidine	10,19	lipoxygenase	40,52	histidine	lipoxygenase	CHEBI:27570	547836(Tax:3847)	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	Conserved histidine residues in soybean lipoxygenase : functional consequences of their replacement .
6360218	0	histidine	30,39	luteinizing_hormone-releasing_hormone	43,80	histidine	luteinizing hormone-releasing hormone	CHEBI:27570	25194(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|agonists agonists|amod|END_ENTITY	Direct tritium-labelling into histidine of luteinizing_hormone-releasing_hormone agonists and use of the tracers in studies on proteolytic breakdown .
8373184	0	histidine	29,38	mitochondrial_aldehyde_dehydrogenase	61,97	histidine	mitochondrial aldehyde dehydrogenase	CHEBI:27570	29539(Tax:10116)	Chemical	Gene	residues|amod|START_ENTITY Role|nmod|residues END_ENTITY|nsubj|Role	Role of the highly conserved histidine residues in rat liver mitochondrial_aldehyde_dehydrogenase as studied by site-directed mutagenesis .
11939778	0	histidine	30,39	myoglobin	60,69	histidine	myoglobin	CHEBI:27570	4151	Chemical	Gene	dynamics|nmod|START_ENTITY replaced|nsubj|dynamics replaced|dobj|mutants mutants|nmod|END_ENTITY	Structural dynamics of distal histidine replaced mutants of myoglobin accompanied with the photodissociation reaction of the ligand .
1518828	0	histidine	29,38	myoglobin	104,113	histidine	myoglobin	CHEBI:27570	102975021	Chemical	Gene	residues|amod|START_ENTITY mutagenesis|nmod|residues involved|nsubj|mutagenesis involved|dobj|binding binding|nmod|END_ENTITY	Site-directed mutagenesis of histidine residues involved in Cu -LRB- II -RRB- binding and reduction by sperm_whale myoglobin .
1954234	0	histidine	55,64	myoglobin	119,128	histidine	myoglobin	CHEBI:27570	102975021	Chemical	Gene	START_ENTITY|nmod|properties properties|nmod|END_ENTITY	Effects of cyanogen bromide modification of the distal histidine on the spectroscopic and ligand binding properties of myoglobin : magnetic circular dichroism spectroscopy as a probe of distal water ligation in ferric high-spin histidine-bound heme proteins .
19924902	0	histidine	18,27	myoglobin	51,60	histidine	myoglobin	CHEBI:27570	100054434(Tax:9796)	Chemical	Gene	residue|compound|START_ENTITY residue|nmod|END_ENTITY	The distal pocket histidine residue in horse heart myoglobin directs the O-binding mode of nitrite to the heme_iron .
20481504	0	histidine	49,58	myoglobin	89,98	histidine	myoglobin	CHEBI:27570	102975021	Chemical	Gene	gate|compound|START_ENTITY open|dobj|gate open|nmod|structures structures|nmod|END_ENTITY	Straight-chain alkyl_isocyanides open the distal histidine gate in crystal structures of myoglobin .
23297402	0	histidine	57,66	myoglobin	43,52	histidine	myoglobin	CHEBI:27570	4151	Chemical	Gene	E7|amod|START_ENTITY END_ENTITY|nmod|E7	Hydrophobic effect drives oxygen uptake in myoglobin via histidine E7 .
2545246	0	histidine	37,46	myoglobin	129,138	histidine	myoglobin	CHEBI:27570	102975021	Chemical	Gene	protonation|compound|START_ENTITY removes|nsubj|protonation removes|dobj|hindrance hindrance|acl|upright upright|nmod|END_ENTITY	Resonance Raman evidence that distal histidine protonation removes the steric hindrance to upright binding of carbon_monoxide by myoglobin .
2611202	0	histidine	21,30	myoglobin	59,68	histidine	myoglobin	CHEBI:27570	4151	Chemical	Gene	modification|compound|START_ENTITY Effect|nmod|modification Effect|nmod|END_ENTITY	Effect of the distal histidine modification -LRB- Cyanation -RRB- of myoglobin on the ligand binding kinetics and the heme environmental structures .
3186740	0	histidine	81,90	myoglobin	35,44	histidine	myoglobin	CHEBI:27570	102975021	Chemical	Gene	role|nmod|START_ENTITY Ligand|dep|role Ligand|nmod|END_ENTITY	Ligand binding to synthetic mutant myoglobin -LRB- His-E7 -- Gly -RRB- : role of the distal histidine .
8011627	0	histidine	42,51	myoglobin	112,121	histidine	myoglobin	CHEBI:27570	4151	Chemical	Gene	START_ENTITY|nmod|mutants mutants|nmod|END_ENTITY	Electron-nuclear coupling to the proximal histidine in oxy cobalt-substituted_distal_histidine mutants of human myoglobin .
9839942	0	histidine	19,28	myoglobin	178,187	histidine	myoglobin	CHEBI:27570	4151	Chemical	Gene	role|nmod|START_ENTITY role|dep|study study|nmod|reaction reaction|nmod|H2O2 H2O2|nmod|END_ENTITY	The role of distal histidine in peroxidase activity of myoglobin -- transient-kinetics study of the reaction of H2O2 with wild-type and distal-histidine-mutanted recombinant human myoglobin .
9839942	0	histidine	19,28	myoglobin	55,64	histidine	myoglobin	CHEBI:27570	4151	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	The role of distal histidine in peroxidase activity of myoglobin -- transient-kinetics study of the reaction of H2O2 with wild-type and distal-histidine-mutanted recombinant human myoglobin .
9915818	0	histidine	34,43	myoglobin	63,72	histidine	myoglobin	CHEBI:27570	102975021	Chemical	Gene	START_ENTITY|nmod|reaction reaction|nmod|END_ENTITY	Effects of the location of distal histidine in the reaction of myoglobin with hydrogen_peroxide .
1999399	0	histidine	42,51	pancreatic_cholesterol_esterase	63,94	histidine	pancreatic cholesterol esterase	CHEBI:27570	24254(Tax:10116)	Chemical	Gene	residue|compound|START_ENTITY residue|nmod|END_ENTITY	Site-specific mutagenesis of an essential histidine residue in pancreatic_cholesterol_esterase .
16639746	0	histidine	57,66	prion_protein	85,98	histidine	prion protein	CHEBI:27570	5621	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Assessing the acid-base and conformational properties of histidine residues in human prion_protein -LRB- 125-228 -RRB- by means of pK -LRB- a -RRB- calculations and molecular dynamics simulations .
18652486	0	histidine	26,35	prolactin	57,66	histidine	prolactin	CHEBI:27570	5617	Chemical	Gene	Analysis|nmod|START_ENTITY protonation|nsubj|Analysis protonation|nmod|END_ENTITY	Analysis of site-specific histidine protonation in human prolactin .
2435588	0	histidine	58,67	prolactin	103,112	histidine	prolactin	CHEBI:27570	24683(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY secretion|compound|END_ENTITY	Vasoactive intestinal peptide and peptide with N-terminal histidine and C-terminal isoleucine increase prolactin secretion in cultured rat pituitary cells -LRB- GH4C1 -RRB- via a cAMP-dependent mechanism which involves transient elevation of intracellular Ca2 + .
23027869	0	histidine	15,24	rhodopsin	32,41	histidine	rhodopsin	CHEBI:27570	6010	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|dobj|END_ENTITY	A photochromic histidine kinase rhodopsin -LRB- HKR1 -RRB- that is bimodally switched by ultraviolet and blue light .
1429502	0	histidine	20,29	ribonuclease	93,105	histidine	ribonuclease	CHEBI:27570	853222(Tax:4932)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Evidence that three histidine residues of a base non-specific and adenylic_acid preferential ribonuclease from Rhizopus niveus are involved in the catalytic function .
2804130	0	histidine	27,36	secretin	48,56	histidine	secretin	CHEBI:27570	6343	Chemical	Gene	residue|amod|START_ENTITY residue|nmod|END_ENTITY	Chemical properties of the histidine residue of secretin : evidence for a specific intramolecular interaction .
3177653	0	histidine	11,20	vasopressin	24,35	histidine	vasopressin	CHEBI:27570	551	Chemical	Gene	START_ENTITY|nmod|action action|compound|END_ENTITY	Effects of histidine on vasopressin action : role of decreased prostaglandin production .
17244493	0	histidine_dipeptides	22,42	cytochrome_c	89,101	histidine dipeptides	cytochrome c	null	54205	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|system system|amod|END_ENTITY	Protective effects of histidine_dipeptides on the modification of neurofilament-L by the cytochrome_c / hydrogen_peroxide system .
2235837	0	histidine_isoleucine	18,38	prolactin	63,72	histidine isoleucine	prolactin	null	100303694(Tax:9103)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Effect of peptide histidine_isoleucine on in vitro and in vivo prolactin secretion in the turkey .
3493951	0	histidine_isoleucine	65,85	prolactin	89,98	histidine isoleucine	prolactin	null	5617	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	In vitro effect of vasoactive_intestinal_polypeptide and peptide histidine_isoleucine on prolactin secretion by the bullfrog pituitary gland .
3841211	0	histidine_isoleucine	23,43	prolactin	53,62	histidine isoleucine	prolactin	null	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Involvement of peptide histidine_isoleucine -LRB- PHI -RRB- in prolactin secretion induced by serotonin in rats .
3493951	0	histidine_isoleucine	65,85	vasoactive_intestinal_polypeptide	19,52	histidine isoleucine	vasoactive intestinal polypeptide	null	7432	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|END_ENTITY	In vitro effect of vasoactive_intestinal_polypeptide and peptide histidine_isoleucine on prolactin secretion by the bullfrog pituitary gland .
6431217	0	histidine_isoleucine_amide	30,56	prolactin	65,74	histidine isoleucine amide	prolactin	null	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	Stimulatory effect of peptide histidine_isoleucine_amide 1-27 on prolactin release in the rat .
26767982	0	histidine_nucleotide	76,96	Hint2	106,111	histidine nucleotide	Hint2	null	68917(Tax:10090)	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Nutritional stress exacerbates hepatic_steatosis induced by deletion of the histidine_nucleotide binding -LRB- Hint2 -RRB- mitochondrial protein .
6414519	0	histidines	45,55	carbonic_anhydrase_I	65,85	histidines	carbonic anhydrase I	null	100050192(Tax:9796)	Chemical	Gene	studies|nmod|START_ENTITY studies|nmod|END_ENTITY	Proton nuclear magnetic resonance studies of histidines in horse carbonic_anhydrase_I .
6788573	0	histidyl-proline-diketopiperazine	15,48	TRH	66,69	histidyl-proline-diketopiperazine	TRH	MESH:C015924	25569(Tax:10116)	Chemical	Gene	START_ENTITY|appos|metabolite metabolite|nmod|END_ENTITY	The effects of histidyl-proline-diketopiperazine , a metabolite of TRH , on prolactin release by the rat pituitary gland in vitro .
3522515	0	histrelin	82,91	LHRH	102,106	histrelin	LHRH	MESH:C029256	25194(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Lack of correlation between fertility and sperm numbers in male rats treated with histrelin , a potent LHRH agonist .
26297807	0	homarine	41,49	cytochrome_P450	53,68	homarine	cytochrome P450	MESH:C010981	4051	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Hard coral -LRB- Porites lobata -RRB- extracts and homarine on cytochrome_P450 expression in Hawaiian butterflyfishes with different feeding strategies .
18066890	0	homo-apioneplanocin_A	29,50	S-adenosylhomocysteine_hydrolase	77,109	homo-apioneplanocin A	S-adenosylhomocysteine hydrolase	MESH:C526391	191	Chemical	Gene	synthesis|nmod|START_ENTITY synthesis|nmod|END_ENTITY	Stereoselective synthesis of homo-apioneplanocin_A as potential inhibitor of S-adenosylhomocysteine_hydrolase .
6621181	0	homo-aza-steroidal_ester	13,37	estrogen_receptor	41,58	homo-aza-steroidal ester	estrogen receptor	null	2099	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of an homo-aza-steroidal_ester on estrogen_receptor .
9723575	0	homocysteine	42,54	B12	82,85	homocysteine	B12	MESH:D006710	4709	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|levels levels|compound|END_ENTITY	Food-bound B12 absorption and serum total homocysteine in patients with low serum B12 levels .
11368701	0	homocysteine	97,109	C-reactive_protein	65,83	homocysteine	C-reactive protein	MESH:D006710	1401	Chemical	Gene	lipoprotein|dep|START_ENTITY lipoprotein|amod|END_ENTITY	Novel risk factors for systemic atherosclerosis : a comparison of C-reactive_protein , fibrinogen , homocysteine , lipoprotein -LRB- a -RRB- , and standard cholesterol screening as predictors of peripheral_arterial_disease .
11401933	0	homocysteine	128,140	C-reactive_protein	85,103	homocysteine	C-reactive protein	MESH:D006710	1401	Chemical	Gene	levels|compound|START_ENTITY END_ENTITY|nmod|levels	Low circulating vitamin_B -LRB- 6 -RRB- is associated with elevation of the inflammation marker C-reactive_protein independently of plasma homocysteine levels .
17761368	0	homocysteine	54,66	C-reactive_protein	25,43	homocysteine	C-reactive protein	MESH:D006710	1401	Chemical	Gene	START_ENTITY|nsubj|concentrations concentrations|nmod|END_ENTITY	Plasma concentrations of C-reactive_protein and total homocysteine in relation to the severity and risk factors for cerebrovascular_disease .
19809863	0	homocysteine	15,27	C-reactive_protein	63,81	homocysteine	C-reactive protein	MESH:D006710	1401	Chemical	Gene	level|compound|START_ENTITY associated|nsubjpass|level associated|nmod|END_ENTITY	Elevated serum homocysteine level is not associated with serum C-reactive_protein in patients with probable Alzheimer 's _ disease .
26742805	0	homocysteine	17,29	C-reactive_protein	31,49	homocysteine	C-reactive protein	MESH:D006710	1401	Chemical	Gene	evaluation|nmod|START_ENTITY evaluation|appos|END_ENTITY	An evaluation of homocysteine , C-reactive_protein , lipid levels , neutrophils to lymphocyte ratio in postmenopausal_osteopenic_women .
27069561	0	homocysteine	37,49	C-reactive_protein	71,89	homocysteine	C-reactive protein	MESH:D006710	1401	Chemical	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Effects of bromocriptine_mesylate on homocysteine and high-sensitivity C-reactive_protein levels in patients with type-2_diabetes_mellitus .
22890010	0	homocysteine	66,78	COMT	15,19	homocysteine	COMT	MESH:D006710	1312	Chemical	Gene	levels|amod|START_ENTITY polymorphisms|nmod|levels polymorphisms|nsubj|Association Association|nmod|END_ENTITY	Association of COMT , MTHFR , and SLC19A1 -LRB- RFC-1 -RRB- polymorphisms with homocysteine blood levels and cognitive_impairment in Parkinson 's _ disease .
10759009	0	homocysteine	19,31	IL-6	41,45	homocysteine	IL-6	MESH:D006710	3569	Chemical	Gene	production|amod|START_ENTITY production|compound|END_ENTITY	Elevated levels of homocysteine increase IL-6 production in monocytic Mono Mac 6 cells .
10977031	0	homocysteine	46,58	Insulin	0,7	homocysteine	Insulin	MESH:D006710	3630	Chemical	Gene	levels|compound|START_ENTITY correlate|nmod|levels correlate|nsubj|END_ENTITY	Insulin is an independent correlate of plasma homocysteine levels in obese children and adolescents .
12660262	0	homocysteine	97,109	Insulin	0,7	homocysteine	Insulin	MESH:D006710	3630	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|resistance resistance|compound|END_ENTITY	Insulin resistance in patients with polycystic_ovary_syndrome is associated with elevated plasma homocysteine .
16083308	0	homocysteine	44,56	Insulin	0,7	homocysteine	Insulin	MESH:D006710	3630	Chemical	Gene	concentration|compound|START_ENTITY related|nmod|concentration related|nsubjpass|resistance resistance|compound|END_ENTITY	Insulin resistance is not related to plasma homocysteine concentration in healthy premenapausal women .
10027946	0	homocysteine	39,51	MTHFR	10,15	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	levels|amod|START_ENTITY total|dobj|levels total|nsubj|Effect Effect|nmod|T T|compound|END_ENTITY	Effect of MTHFR 677C > T on plasma total homocysteine levels in renal graft recipients .
10365747	0	homocysteine	93,105	MTHFR	37,42	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	relationship|nmod|START_ENTITY relationship|nmod|mutations mutations|nmod|END_ENTITY	The relationship of mutations in the MTHFR , prothrombin , and PAI-1 genes to plasma levels of homocysteine , prothrombin , and PAI-1 in children and adults .
10524453	0	homocysteine	45,57	MTHFR	25,30	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	levels|amod|START_ENTITY genotype|nmod|levels genotype|nsubj|Correlation Correlation|nmod|END_ENTITY	Correlation of the C677T MTHFR genotype with homocysteine levels in children with sickle_cell_disease .
10650848	0	homocysteine	71,83	MTHFR	32,37	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	thermolabile|dobj|START_ENTITY thermolabile|nsubj|genotype genotype|nmod|END_ENTITY	The 677T genotype of the common MTHFR thermolabile variant and fasting homocysteine in childhood_venous_thrombosis .
10706928	12	homocysteine	2342,2354	MTHFR	2297,2302	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	levels|compound|START_ENTITY associated|nmod|levels associated|nsubjpass|homozygosity homozygosity|nmod|genotype genotype|nmod|gene gene|amod|END_ENTITY	In conclusion , even though homozygosity for the VV genotype of the MTHFR gene was associated with higher plasma homocysteine levels , we found no association between plasma levels of homocysteine and DVT or between the genotype of the MTHFR gene and the DVT incidence .
10706928	12	homocysteine	2412,2424	MTHFR	2297,2302	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	levels|nmod|START_ENTITY found|nmod|levels found|advcl|associated associated|nsubjpass|homozygosity homozygosity|nmod|genotype genotype|nmod|gene gene|amod|END_ENTITY	In conclusion , even though homozygosity for the VV genotype of the MTHFR gene was associated with higher plasma homocysteine levels , we found no association between plasma levels of homocysteine and DVT or between the genotype of the MTHFR gene and the DVT incidence .
11004224	0	homocysteine	64,76	MTHFR	10,15	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	genotypes|nmod|START_ENTITY Effect|dep|genotypes Effect|nmod|END_ENTITY	Effect of MTHFR 1298A -- > C and MTHFR 677C -- > T genotypes on total homocysteine , folate , and vitamin_B -LRB- 12 -RRB- plasma concentrations in kdiney graft recipients .
11257266	0	homocysteine	130,142	MTHFR	59,64	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	levels|compound|START_ENTITY impact|nmod|levels polymorphisms|dep|impact resulting|nmod|polymorphisms genotypes|xcomp|resulting genotypes|nsubj|Identification Identification|nmod|methylenetetrahydrofolate_reductase methylenetetrahydrofolate_reductase|appos|END_ENTITY	Identification of six methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- genotypes resulting from common polymorphisms : impact on plasma homocysteine levels and development of coronary_artery_disease .
11395038	0	homocysteine	116,128	MTHFR	67,72	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	vitro|nmod|START_ENTITY methylenetetrahydrofolate_reductase|acl|vitro methylenetetrahydrofolate_reductase|appos|END_ENTITY	The 1298A -- > C polymorphism in methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- : in vitro expression and association with homocysteine .
11431185	0	homocysteine	50,62	MTHFR	19,24	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	levels|amod|START_ENTITY polymorphisms|nmod|levels polymorphisms|nsubj|Association Association|nmod|END_ENTITY	Association of two MTHFR polymorphisms with total homocysteine plasma levels in dialysis patients .
11683544	0	homocysteine	25,37	MTHFR	0,5	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	START_ENTITY|nsubj|polymorphism polymorphism|amod|END_ENTITY	MTHFR gene polymorphism , homocysteine and cardiovascular_disease .
11872884	0	homocysteine	7,19	MTHFR	41,46	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	START_ENTITY|dep|genotype genotype|nsubj|END_ENTITY	Plasma homocysteine concentration , C677T MTHFR genotype , and 844ins68bp CBS genotype in young adults with spontaneous cervical artery_dissection and atherothrombotic_stroke .
12033523	0	homocysteine	73,85	MTHFR	192,197	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	START_ENTITY|nmod|polymorphism polymorphism|nmod|gene gene|appos|END_ENTITY	Are the associations between life-style related factors and plasma total homocysteine concentration different according to polymorphism of 5,10-methylenetetrahydrofolate reductase gene -LRB- C677T MTHFR -RRB- ?
12801615	0	homocysteine	136,148	MTHFR	37,42	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	association|nmod|START_ENTITY Methylenetetrahydrofolate_reductase|dep|association Methylenetetrahydrofolate_reductase|appos|END_ENTITY	Methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- 677C > T and methionine_synthase_reductase -LRB- MTRR -RRB- 66A > G polymorphisms : association with serum homocysteine and angiographic coronary_artery_disease in the era of flour products fortified with folic_acid .
12949355	0	homocysteine	54,66	MTHFR	148,153	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	methylation|amod|START_ENTITY affect|dobj|methylation affect|nmod|homozygous homozygous|nmod|mutation mutation|compound|END_ENTITY	Combined marginal folate and riboflavin status affect homocysteine methylation in cultured immortalized lymphocytes from persons homozygous for the MTHFR C677T mutation .
14717963	0	homocysteine	176,188	MTHFR	66,71	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	levels|amod|START_ENTITY hormones|nmod|levels effect|nmod|hormones levels|dep|effect levels|appos|methylenetetrahydrofolate_reductase methylenetetrahydrofolate_reductase|appos|END_ENTITY	Folate , homocysteine levels , methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- 677C _ -- > _ T variant , and the risk of myocardial_infarction in young women : effect of female hormones on homocysteine levels .
14717963	0	homocysteine	8,20	MTHFR	66,71	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	levels|amod|START_ENTITY levels|appos|methylenetetrahydrofolate_reductase methylenetetrahydrofolate_reductase|appos|END_ENTITY	Folate , homocysteine levels , methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- 677C _ -- > _ T variant , and the risk of myocardial_infarction in young women : effect of female hormones on homocysteine levels .
15054427	0	homocysteine	44,56	MTHFR	87,92	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	concentrations|amod|START_ENTITY total|dobj|concentrations total|nmod|genotype genotype|compound|END_ENTITY	Effect of lifestyle factors on plasma total homocysteine concentrations in relation to MTHFR -LRB- C677T -RRB- genotype .
15060097	4	homocysteine	562,574	MTHFR	584,589	homocysteine	RFC-1	MESH:D006710	5981	Chemical	Gene	pathway|compound|START_ENTITY pathway|dep|END_ENTITY	MAIN OUTCOME MEASURES : Seven polymorphisms in six genes coding for proteins in the folate-dependent homocysteine pathway -LRB- MTHFR 677C -- > T , MTHFR 1298A -- > C , MTRR_66A -- > G , SHMT 1420C -- > T , CbetaS_844ins68 , GCPII 1561C -- > T , RFC-1_80G -- > A -RRB- .
15207432	0	homocysteine	95,107	MTHFR	61,66	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	concentrations|compound|START_ENTITY relationships|nmod|concentrations polymorphisms|dep|relationships polymorphisms|nmod|methylenetetrahydrofolate_reductase methylenetetrahydrofolate_reductase|appos|END_ENTITY	Common polymorphisms in methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- : relationships with plasma homocysteine concentrations and cognitive status in elderly northern italian subjects .
15840047	0	homocysteine	52,64	MTHFR	21,26	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	total|dobj|START_ENTITY total|nsubj|Associations Associations|nmod|A A|compound|END_ENTITY	Associations between MTHFR 1793G > A and plasma total homocysteine , folate , and vitamin_B in kidney transplant recipients .
15916056	0	homocysteine	80,92	MTHFR	37,42	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	concentration|amod|START_ENTITY relation|nmod|concentration polymorphism|nmod|relation polymorphism|appos|END_ENTITY	Methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- polymorphism -LRB- C677T -RRB- in relation to homocysteine concentration in overweight and obese Thais .
15985285	0	homocysteine	138,150	MTHFR	59,64	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	levels|amod|START_ENTITY plasma|dobj|levels polymorphisms|xcomp|plasma polymorphisms|nsubj|Influence Influence|nmod|methylenetetrahydrofolate_reductase methylenetetrahydrofolate_reductase|appos|END_ENTITY	Influence of combined methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- and thymidylate synthase enhancer region -LRB- TSER -RRB- polymorphisms to plasma homocysteine levels in Korean patients with recurrent spontaneous_abortion .
16216822	0	homocysteine	122,134	MTHFR	17,22	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	potential|amod|START_ENTITY role|nmod|potential does|nsubj|role Meta-analysis|parataxis|does Meta-analysis|nmod|END_ENTITY	Meta-analysis of MTHFR 677C - > T polymorphism and coronary_heart_disease : does totality of evidence support causal role for homocysteine and preventive potential of folate ?
16234842	0	homocysteine	46,58	MTHFR	14,19	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	concentrations|compound|START_ENTITY effect|nmod|concentrations effect|nmod|genotype genotype|compound|END_ENTITY	The effect of MTHFR -LRB- C677T -RRB- genotype on plasma homocysteine concentrations in healthy children is influenced by gender .
16268464	0	homocysteine	100,112	MTHFR	49,54	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	Association|nmod|START_ENTITY Association|dep|not not|nmod|C677T C677T|compound|END_ENTITY	Association of MTRRA66G polymorphism -LRB- but not of MTHFR C677T and A1298C , MTRA2756G , TCN C776G -RRB- with homocysteine and coronary_artery_disease in the French population .
16317120	8	homocysteine	1255,1267	MTHFR	1232,1237	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	subjects|nsubj|START_ENTITY subjects|nmod|subjects subjects|nmod|genotype genotype|compound|END_ENTITY	In subjects with the MTHFR 677 CC genotype , homocysteine was greater -LRB- P < or = 0.05 -RRB- for GNMT 1289 TT subjects relative to 1289 CT or CC subjects .
16340945	0	homocysteine	31,43	MTHFR	59,64	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	START_ENTITY|nmod|genotype genotype|compound|END_ENTITY	Changes in lifestyle and total homocysteine in relation to MTHFR -LRB- C677T -RRB- genotype : the Inter99 study .
16379339	0	homocysteine	116,128	MTHFR	50,55	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	C677T|nmod|START_ENTITY C677T|nsubj|Influence Influence|appos|END_ENTITY	Influence of methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- C677T polymorphism , B vitamins and other factors on plasma homocysteine and risk of thromboembolic_disease in Chinese .
16380544	0	homocysteine	18,30	MTHFR	65,70	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	homozygous|amod|START_ENTITY homozygous|nmod|END_ENTITY	Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C - > T polymorphism .
16894458	0	homocysteine	15,27	MTHFR	40,45	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	Association|nmod|START_ENTITY Association|dep|T T|nmod|END_ENTITY	Association of homocysteine -LRB- but not of MTHFR 677_C > T , MTR 2756_A > G , MTRR 66_A > G and TCN2 776_C > G -RRB- with ischaemic_cerebrovascular_disease in Sicily .
17141597	0	homocysteine	19,31	MTHFR	53,58	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	association|nmod|START_ENTITY END_ENTITY|nsubj|association	The association of homocysteine and its determinants MTHFR genotype , folate , vitamin_B12 and vitamin_B6 with bone_mineral_density in postmenopausal British women .
17243563	0	homocysteine	93,105	MTHFR	42,47	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	levels|compound|START_ENTITY genotypes|nmod|levels genotypes|nsubj|Association Association|nmod|methylenetetrahydrofolate methylenetetrahydrofolate|appos|END_ENTITY	Association of methylenetetrahydrofolate -LRB- MTHFR -RRB- and apolipoprotein_E -LRB- apo_E -RRB- genotypes with homocysteine , vitamin and lipid levels in carotid_stenosis .
17712942	0	homocysteine	134,146	MTHFR	41,46	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	-RSB-|amod|START_ENTITY induced|nmod|-RSB- induced|nsubj|Demethylation Demethylation|nmod|region region|nmod|gene gene|amod|END_ENTITY	-LSB- Demethylation in the promoter region of MTHFR gene and its mRNA expression in cultured human vascular smooth muscle cells induced by homocysteine -RSB- .
18622257	0	homocysteine	64,76	MTHFR	86,91	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	pathway|amod|START_ENTITY pathway|dep|T T|compound|END_ENTITY	Interactions between the single nucleotide polymorphisms in the homocysteine pathway -LRB- MTHFR 677C > T , MTHFR 1298_A > C , and CBSins -RRB- and the efficacy of HMG-CoA reductase inhibitors in preventing cardiovascular_disease in high-risk patients of hypertension : the GenHAT study .
19063701	0	homocysteine	12,24	MTHFR	76,81	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	reductase|amod|START_ENTITY reductase|appos|END_ENTITY	Serum total homocysteine , folate , 5,10-methylenetetrahydrofolate _ reductase -LRB- MTHFR -RRB- 677C -- > T genotype and subclinical atherosclerosis .
19142139	0	homocysteine	7,19	MTHFR	21,26	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	START_ENTITY|appos|mutation mutation|amod|END_ENTITY	Plasma homocysteine , MTHFR gene mutation , and open-angle_glaucoma .
19398669	0	homocysteine	91,103	MTHFR	0,5	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	importance|amod|START_ENTITY reveals|dobj|importance reveals|nsubj|Polymorphism Polymorphism|compound|END_ENTITY	MTHFR 677_C > T Polymorphism reveals functional importance for 5-methyltetrahydrofolate , not homocysteine , in regulation of vascular redox state and endothelial function in human atherosclerosis .
19424840	0	homocysteine	53,65	MTHFR	95,100	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	levels|compound|START_ENTITY levels|appos|independent independent|nmod|genotype genotype|compound|END_ENTITY	Physical activity is inversely associated with total homocysteine levels , independent of C677T MTHFR genotype and plasma B vitamins .
19598005	2	homocysteine	312,324	MTHFR	257,262	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	levels|compound|START_ENTITY increase|nmod|levels results|nmod|increase results|amod|END_ENTITY	A point mutation -LRB- 677_C-T -RRB- of MTHFR gene results in a significant increase at plasma homocysteine levels .
19654594	0	homocysteine	56,68	MTHFR	84,89	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	START_ENTITY|nmod|relation relation|nmod|C677T C677T|compound|END_ENTITY	Changes in lifestyle , biological risk factors and total homocysteine in relation to MTHFR C677T genotype : a 5-year follow-up study .
20003837	0	homocysteine	39,51	MTHFR	14,19	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	levels|compound|START_ENTITY T|nmod|levels T|compound|END_ENTITY	The effect of MTHFR c. 677C > T on plasma homocysteine levels depends on health , age and smoking .
20065615	0	homocysteine	54,66	MTHFR	37,42	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	plasma|amod|START_ENTITY gene|appos|plasma gene|amod|END_ENTITY	Association of C677T polymorphism in MTHFR gene , high homocysteine and low HDL cholesterol plasma values in heterozygous familial_hypercholesterolemia .
20097536	0	homocysteine	88,100	MTHFR	51,56	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	concentrations|compound|START_ENTITY Effect|nmod|concentrations Effect|nmod|polymorphism polymorphism|appos|T T|compound|END_ENTITY	Effect of the methylenetetrahydrofolate_reductase -LRB- MTHFR 677C > T -RRB- polymorphism on plasma homocysteine concentrations in healthy children is influenced by consumption of folate-fortified foods .
20221815	0	homocysteine	57,69	MTHFR	0,5	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	START_ENTITY|nsubj|polymorphism polymorphism|amod|END_ENTITY	MTHFR gene polymorphism and its relationship with plasma homocysteine and folate in a North Indian population .
20429317	0	homocysteine	7,19	MTHFR	55,60	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	level|compound|START_ENTITY level|dep|mutation mutation|nmod|gene gene|amod|END_ENTITY	Plasma homocysteine level and 677C -- > T mutation on the MTHFR gene in patients with venous_thromboembolism .
20530057	0	homocysteine	49,61	MTHFR	25,30	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	polymorphism|nmod|START_ENTITY polymorphism|nsubj|Association Association|nmod|END_ENTITY	Association of the C677T MTHFR polymorphism with homocysteine , ox-LDL levels , and thiolactonase activities in the severity of coronary_syndrome .
20888556	0	homocysteine	67,79	MTHFR	17,22	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	concentration|compound|START_ENTITY associated|nmod|concentration associated|nsubj|Polymorphisms Polymorphisms|nmod|genes genes|compound|END_ENTITY	Polymorphisms in MTHFR and MTRR genes associated with blood plasma homocysteine concentration and sperm counts .
21543238	0	homocysteine	54,66	MTHFR	0,5	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	concentrations|amod|START_ENTITY polymorphisms|advcl|concentrations polymorphisms|nsubj|MTR MTR|compound|END_ENTITY	MTHFR , MTR , and MTHFD1 gene polymorphisms compared to homocysteine and asymmetric dimethylarginine concentrations and their metabolites in epileptic patients treated with antiepileptic_drugs .
21577095	0	homocysteine	80,92	MTHFR	15,20	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	levels|compound|START_ENTITY Association|nmod|levels Association|nmod|polymorphism polymorphism|compound|END_ENTITY	Association of MTHFR A1298C polymorphism -LRB- but not of MTHFR C677T -RRB- with elevated homocysteine levels and placental vasculopathies .
21577095	0	homocysteine	80,92	MTHFR	53,58	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	levels|compound|START_ENTITY Association|nmod|levels Association|dep|not not|nmod|C677T C677T|compound|END_ENTITY	Association of MTHFR A1298C polymorphism -LRB- but not of MTHFR C677T -RRB- with elevated homocysteine levels and placental vasculopathies .
21637473	0	homocysteine	15,27	MTHFR	70,75	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	gene|amod|START_ENTITY gene|appos|C677T C677T|compound|END_ENTITY	Association of homocysteine and methylene_tetrahydrofolate reductase -LRB- MTHFR C677T -RRB- gene polymorphism with coronary_artery_disease -LRB- CAD -RRB- in the population of North India .
21681722	0	homocysteine	87,99	MTHFR	22,27	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	levels|amod|START_ENTITY polymorphism|nmod|levels polymorphism|nsubj|polymorphism polymorphism|nmod|END_ENTITY	C677t polymorphism of MTHFR and G80A polymorphism of RFC genes and their relation with homocysteine levels in obese Tunisian children .
21854603	0	homocysteine	79,91	MTHFR	37,42	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	C677T|dobj|START_ENTITY C677T|nsubj|Methylenetetrahydrofolate_reductase Methylenetetrahydrofolate_reductase|appos|END_ENTITY	Methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- C677T polymorphism and high plasma homocysteine in chronic_hepatitis_C -LRB- CHC -RRB- infected patients from the Northeast of Brazil .
22219102	0	homocysteine	63,75	MTHFR	10,15	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	concentration|amod|START_ENTITY Impact|nmod|concentration Impact|nmod|polymorphism polymorphism|amod|END_ENTITY	Impact of MTHFR C677T gene polymorphism and vitamins intake on homocysteine concentration in the Polish adult population .
22425007	0	homocysteine	32,44	MTHFR	113,118	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	level|amod|START_ENTITY Role|nmod|level Role|nmod|genotypes genotypes|compound|END_ENTITY	Role of folic_acid depletion on homocysteine serum level in children and adolescents with epilepsy and different MTHFR C677T genotypes .
22664498	0	homocysteine	8,20	MTHFR	23,28	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Role of homocysteine _ MTHFR C677T gene polymorphism as risk factors for coronary_artery_disease in young Indians .
23314883	0	homocysteine	77,89	MTHFR	117,122	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	enzyme|amod|START_ENTITY enzyme|appos|C677T C677T|compound|END_ENTITY	Plaque image characteristics , hyperhomocysteinemia , and gene polymorphism of homocysteine metabolism-related enzyme -LRB- MTHFR C677T -RRB- in acute_coronary_syndrome .
23548740	0	homocysteine	90,102	MTHFR	50,55	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	polymorphism|acl|START_ENTITY polymorphism|compound|END_ENTITY	Nutritional genetics : the case of alcohol and the MTHFR C677T polymorphism in relation to homocysteine in a black South African population .
23856949	0	homocysteine	59,71	MTHFR	117,122	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	START_ENTITY|advcl|represented represented|nmod|genotype genotype|compound|END_ENTITY	Mendelian randomization analysis of the effect of maternal homocysteine during pregnancy , as represented by maternal MTHFR C677T genotype , on birth weight .
23866722	0	homocysteine	90,102	MTHFR	54,59	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	START_ENTITY|nsubj|polymorphism polymorphism|appos|T T|compound|END_ENTITY	The methylenetetrahydrofolate_reductase polymorphism -LRB- MTHFR c. 677C > T -RRB- and elevated plasma homocysteine levels in a U.S. pediatric population with incident thromboembolism .
23954866	0	homocysteine	104,116	MTHFR	56,61	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	relation|acl|START_ENTITY interactions|nmod|relation interactions|nmod|variants variants|compound|END_ENTITY	Gene-environment and gene-gene interactions of specific MTHFR , MTR and CBS gene variants in relation to homocysteine in black South Africans .
24014284	0	homocysteine	31,43	MTHFR	90,95	homocysteine	MTHFR	MESH:D006710	101111645	Chemical	Gene	association|nmod|START_ENTITY modified|nsubjpass|association modified|nmod|polymorphism polymorphism|compound|END_ENTITY	The association between plasma homocysteine and coronary_heart_disease is modified by the MTHFR 677C > T polymorphism .
24277487	0	homocysteine	121,133	MTHFR	42,47	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	levels|amod|START_ENTITY frequency|nmod|levels C677T|dep|frequency C677T|appos|END_ENTITY	5,10-Methylenetetrahydrofolate _ reductase -LRB- MTHFR -RRB- C677T and A1298C polymorphisms : genotype frequency and association with homocysteine and folate levels in middle-southern Italian adults .
24535549	0	homocysteine	23,35	MTHFR	93,98	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	START_ENTITY|dobj|levels levels|nmod|polymorphism polymorphism|compound|END_ENTITY	Meta-analyses of blood homocysteine levels for gender and genetic association studies of the MTHFR C677T polymorphism in schizophrenia .
24652221	0	homocysteine	74,86	MTHFR	117,122	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	levels|amod|START_ENTITY supplementation|nmod|levels supplementation|nmod|patients patients|nmod|genotypes genotypes|compound|END_ENTITY	Influence of dialysis techniques and alternate vitamin supplementation on homocysteine levels in patients with known MTHFR genotypes .
25165408	0	homocysteine	94,106	MTHFR	35,40	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	levels|compound|START_ENTITY Association|nmod|levels Association|nmod|gene gene|amod|END_ENTITY	Association of tagging SNPs in the MTHFR gene with risk of type_2_diabetes_mellitus and serum homocysteine levels in a Chinese population .
25176448	0	homocysteine	54,66	MTHFR	0,5	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	concentrations|compound|START_ENTITY affect|dobj|concentrations affect|nsubj|polymorphisms polymorphisms|amod|END_ENTITY	MTHFR polymorphisms and serum cobalamin affect plasma homocysteine concentrations differentially in females and males .
25322900	0	homocysteine	144,156	MTHFR	79,84	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	modifies|nmod|START_ENTITY modifies|dobj|effects effects|nmod|polymorphisms polymorphisms|amod|methylenetetrahydrofolate_reductase methylenetetrahydrofolate_reductase|dep|END_ENTITY	Riboflavin status modifies the effects of methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- and methionine_synthase_reductase -LRB- MTRR -RRB- polymorphisms on homocysteine .
25564416	0	homocysteine	38,50	MTHFR	15,20	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	levels|compound|START_ENTITY C677T|nmod|levels C677T|compound|END_ENTITY	Association of MTHFR C677T with total homocysteine plasma levels and susceptibility to Parkinson 's _ disease : a meta-analysis .
26559681	0	homocysteine	113,125	MTHFR	10,15	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	lowering|dobj|START_ENTITY influence|advcl|lowering influence|nsubj|genotypes genotypes|compound|END_ENTITY	The C677T MTHFR genotypes influence the efficacy of B9 and B12_vitamins supplementation to lowering plasma total homocysteine in hemodialysis .
27035272	0	homocysteine	38,50	MTHFR	142,147	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	reduction|amod|START_ENTITY Correlation|nmod|reduction Correlation|nmod|MDD MDD|acl:relcl|positive positive|nmod|C677T C677T|compound|END_ENTITY	Correlation of clinical response with homocysteine reduction during therapy with reduced_B_vitamins in patients with MDD who are positive for MTHFR C677T or A1298C polymorphism : a randomized , double-blind , placebo-controlled study .
9543106	0	homocysteine	132,144	MTHFR	89,94	homocysteine	MTHFR	MESH:D006710	4524	Chemical	Gene	concentration|compound|START_ENTITY frequency|nmod|concentration polymorphism|dep|frequency polymorphism|nmod|methylenetetrahydrofolate_reductase methylenetetrahydrofolate_reductase|appos|END_ENTITY	C677T -LRB- thermolabile alanine/valine -RRB- polymorphism in methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- : its frequency and impact on plasma homocysteine concentration in different European populations .
9680386	0	homocysteine	229,241	MTHFR	71,76	homocysteine	MTHFR	MESH:D006710	17769(Tax:10090)	Chemical	Gene	co-substrate|nmod|START_ENTITY 5-methyltetrahydrofolate|appos|co-substrate 5,10-methylenetetrahydrofolate|nmod|5-methyltetrahydrofolate remethylation|amod|5,10-methylenetetrahydrofolate conversion|nmod|remethylation catalyzes|dobj|conversion catalyzes|nsubj|structure structure|nmod|Methylenetetrahydrofolate_reductase Methylenetetrahydrofolate_reductase|appos|END_ENTITY	Gene structure of human and mouse methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- Methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate , a co-substrate for homocysteine remethylation to methionine .
19219535	0	homocysteine	100,112	Methylenetetrahydrofolate_Reductase	35,70	homocysteine	Methylenetetrahydrofolate Reductase	MESH:D006710	4524	Chemical	Gene	Association|nmod|START_ENTITY Association|nmod|variants variants|nmod|genes genes|compound|END_ENTITY	Association of genetic variants in Methylenetetrahydrofolate_Reductase and Paraoxonase-1 genes with homocysteine , folate and vitamin_B12 in coronary_artery_disease .
10583447	0	homocysteine	57,69	Methylenetetrahydrofolate_reductase	0,35	homocysteine	Methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Methylenetetrahydrofolate_reductase polymorphism , plasma homocysteine and age .
11092508	0	homocysteine	85,97	Methylenetetrahydrofolate_reductase	0,35	homocysteine	Methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	response|compound|START_ENTITY influences|dobj|response influences|nsubj|mutation mutation|amod|END_ENTITY	Methylenetetrahydrofolate_reductase mutation -LRB- 677C -- > T -RRB- negatively influences plasma homocysteine response to marginal folate intake in elderly women .
11979347	0	homocysteine	87,99	Methylenetetrahydrofolate_reductase	0,35	homocysteine	Methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	START_ENTITY|nsubj|genotype genotype|amod|END_ENTITY	Methylenetetrahydrofolate_reductase genotype , vitamin_B12 , and folate influence plasma homocysteine in hemodialysis patients .
12081832	0	homocysteine	64,76	Methylenetetrahydrofolate_reductase	0,35	homocysteine	Methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	responses|amod|START_ENTITY END_ENTITY|dep|responses	Methylenetetrahydrofolate_reductase 677C -- > T genotype modulates homocysteine responses to a folate-rich diet or a low-dose folic_acid supplement : a randomized controlled trial .
12187113	0	homocysteine	68,80	Methylenetetrahydrofolate_reductase	0,35	homocysteine	Methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Methylenetetrahydrofolate_reductase gene C677T polymorphism , plasma homocysteine and folate in end-stage_renal_disease dialysis and non-dialysis patients .
12801615	0	homocysteine	136,148	Methylenetetrahydrofolate_reductase	0,35	homocysteine	Methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	association|nmod|START_ENTITY END_ENTITY|dep|association	Methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- 677C > T and methionine_synthase_reductase -LRB- MTRR -RRB- 66A > G polymorphisms : association with serum homocysteine and angiographic coronary_artery_disease in the era of flour products fortified with folic_acid .
15916056	0	homocysteine	80,92	Methylenetetrahydrofolate_reductase	0,35	homocysteine	Methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	concentration|amod|START_ENTITY relation|nmod|concentration polymorphism|nmod|relation polymorphism|amod|END_ENTITY	Methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- polymorphism -LRB- C677T -RRB- in relation to homocysteine concentration in overweight and obese Thais .
17323822	0	homocysteine	97,109	Methylenetetrahydrofolate_reductase	0,35	homocysteine	Methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	impact|nmod|START_ENTITY polymorphisms|dep|impact polymorphisms|amod|END_ENTITY	Methylenetetrahydrofolate_reductase gene polymorphisms in Burkina Faso : impact on plasma fasting homocysteine and after methionine loading test .
18384842	0	homocysteine	42,54	Methylenetetrahydrofolate_reductase	0,35	homocysteine	Methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Methylenetetrahydrofolate_reductase gene , homocysteine and coronary_artery_disease : the A1298C polymorphism does matter .
20492738	0	homocysteine	134,146	Methylenetetrahydrofolate_reductase	0,35	homocysteine	Methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	concentrations|compound|START_ENTITY association|nmod|concentrations mutation|dep|association mutation|compound|END_ENTITY	Methylenetetrahydrofolate_reductase C677T gene mutation as risk factor for sudden sensorineural_hearing_loss : association with plasma homocysteine , folate and cholesterol concentrations .
21270364	0	homocysteine	170,182	Methylenetetrahydrofolate_reductase	0,35	homocysteine	Methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubj|variants variants|amod|END_ENTITY	Methylenetetrahydrofolate_reductase variants associated with hypertension and cardiovascular_disease interact with dietary polyunsaturated_fatty_acids to modulate plasma homocysteine in puerto rican adults .
21854603	0	homocysteine	79,91	Methylenetetrahydrofolate_reductase	0,35	homocysteine	Methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	C677T|dobj|START_ENTITY C677T|nsubj|END_ENTITY	Methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- C677T polymorphism and high plasma homocysteine in chronic_hepatitis_C -LRB- CHC -RRB- infected patients from the Northeast of Brazil .
24851035	0	homocysteine	86,98	Methylenetetrahydrofolate_reductase	0,35	homocysteine	Methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	677|nmod|START_ENTITY 677|advmod|END_ENTITY	Methylenetetrahydrofolate_reductase 677 genotype-specific reference values for plasma homocysteine and serum folate concentrations in korean population aged 45 to 74 years : the Namwon study .
9687553	0	homocysteine	71,83	Methylenetetrahydrofolate_reductase	0,35	homocysteine	Methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	concentrations|amod|START_ENTITY change|nmod|concentrations folic_acid|nsubj|change affects|ccomp|folic_acid affects|nsubj|polymorphism polymorphism|compound|END_ENTITY	Methylenetetrahydrofolate_reductase polymorphism affects the change in homocysteine and folate concentrations resulting from low dose folic_acid supplementation in women with unexplained recurrent miscarriages .
12689917	0	homocysteine	45,57	NOS3	63,67	homocysteine	NOS3	MESH:D006710	4846	Chemical	Gene	START_ENTITY|dobj|genotype genotype|compound|END_ENTITY	Genetic evidence that nitric_oxide modulates homocysteine : the NOS3 894TT genotype is a risk factor for hyperhomocystenemia .
17117898	0	homocysteine	37,49	NOS3	96,100	homocysteine	NOS3	MESH:D006710	4846	Chemical	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Arterial blood pressure variations : homocysteine and nitric_oxide synthase gene polymorphisms -LRB- NOS3 -RRB- -RSB- .
19158324	0	homocysteine	14,26	PGC-1alpha	79,89	homocysteine	PGC-1alpha	MESH:D006710	10891	Chemical	Gene	Regulation|nmod|START_ENTITY homeostasis|nsubj|Regulation homeostasis|nmod|END_ENTITY	Regulation of homocysteine homeostasis through the transcriptional coactivator PGC-1alpha .
17063483	0	homocysteine	47,59	PLCgamma2	11,20	homocysteine	PLCgamma2	MESH:D006710	5336	Chemical	Gene	activation|nmod|START_ENTITY activation|nsubj|role role|nmod|END_ENTITY	A role for PLCgamma2 in platelet activation by homocysteine .
12738777	0	homocysteine	21,33	TDAG51	0,6	homocysteine	TDAG51	MESH:D006710	21664(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	TDAG51 is induced by homocysteine , promotes detachment-mediated programmed_cell_death , and contributes to the cevelopment of atherosclerosis in hyperhomocysteinemia .
10524225	0	homocysteine	93,105	TIMP-1	13,19	homocysteine	TIMP-1	MESH:D006710	116510(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY Induction|dep|role Induction|nmod|expression expression|compound|END_ENTITY	Induction of TIMP-1 expression in rat hepatic stellate cells and hepatocytes : a new role for homocysteine in liver_fibrosis .
18458991	0	homocysteine	58,70	Thymidylate_synthase	0,20	homocysteine	Thymidylate synthase	MESH:D006710	7298	Chemical	Gene	genotype|nmod|START_ENTITY genotype|amod|END_ENTITY	Thymidylate_synthase genotype and serum concentrations of homocysteine and folate in Beh __ et 's _ disease .
17597160	0	homocysteine	9,21	VEGF	57,61	homocysteine	VEGF	MESH:D006710	7422	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|levels levels|nmod|END_ENTITY	Lowering homocysteine decreases levels and expression of VEGF -LRB- 165 -RRB- and endostatin .
19525478	0	homocysteine	67,79	ZNF366	18,24	homocysteine	ZNF366	MESH:D006710	167465	Chemical	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification of ZNF366 and PTPRD as novel determinants of plasma homocysteine in a family-based genome-wide association study .
20580032	0	homocysteine	37,49	adiponectin	6,17	homocysteine	adiponectin	MESH:D006710	9370	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	Serum adiponectin is associated with homocysteine in elderly men and women , and with 5,10-methylenetetrahydrofolate reductase -LRB- MTHFR -RRB- in a sex-dependent manner .
17243563	0	homocysteine	93,105	apo_E	71,76	homocysteine	apo E	MESH:D006710	348	Chemical	Gene	levels|compound|START_ENTITY genotypes|nmod|levels genotypes|nsubj|Association Association|nmod|methylenetetrahydrofolate methylenetetrahydrofolate|appos|END_ENTITY	Association of methylenetetrahydrofolate -LRB- MTHFR -RRB- and apolipoprotein_E -LRB- apo_E -RRB- genotypes with homocysteine , vitamin and lipid levels in carotid_stenosis .
16439690	0	homocysteine	9,21	apolipoprotein_A-I	30,48	homocysteine	apolipoprotein A-I	MESH:D006710	11806(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|amod|END_ENTITY	Elevated homocysteine reduces apolipoprotein_A-I expression in hyperhomocysteinemic mice and in males with coronary_artery_disease .
15500781	0	homocysteine	78,90	calcitonin_gene-related_peptide	32,63	homocysteine	calcitonin gene-related peptide	MESH:D006710	796	Chemical	Gene	START_ENTITY|nsubj|relationship relationship|nmod|END_ENTITY	-LSB- The relationship between serum calcitonin_gene-related_peptide , sex hormone , homocysteine and coronary_artery_disease in postmenopausal women -RSB- .
16616146	0	homocysteine	11,23	caveolin-1	41,51	homocysteine	caveolin-1	MESH:D006710	857	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|nmod|END_ENTITY	Effects of homocysteine on the levels of caveolin-1 and eNOS in caveolae of human coronary artery endothelial cells .
8550827	0	homocysteine	41,53	cyclin_A	13,21	homocysteine	cyclin A	MESH:D006710	890	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Induction of cyclin_A gene expression by homocysteine in vascular smooth muscle cells .
11149614	0	homocysteine	100,112	cystathionine_beta-synthase	57,84	homocysteine	cystathionine beta-synthase	MESH:D006710	875	Chemical	Gene	levels|compound|START_ENTITY gene|nmod|levels gene|amod|END_ENTITY	Influence of 699C -- > T and 1080C -- > T polymorphisms of the cystathionine_beta-synthase gene on plasma homocysteine levels .
15890029	0	homocysteine	43,55	cystathionine_beta-synthase	12,39	homocysteine	cystathionine beta-synthase	MESH:D006710	875	Chemical	Gene	metabolism|amod|START_ENTITY role|nmod|metabolism role|nmod|END_ENTITY	The role of cystathionine_beta-synthase in homocysteine metabolism .
10430785	0	homocysteine	7,19	endothelin_and_von_Willebrand_factor	53,89	homocysteine	endothelin and von Willebrand factor	MESH:D006710	7450	Chemical	Gene	correlated|nsubjpass|START_ENTITY correlated|nmod|END_ENTITY	Plasma homocysteine is weakly correlated with plasma endothelin_and_von_Willebrand_factor but not with endothelium-dependent vasodilatation in healthy postmenopausal women .
14608049	0	homocysteine	103,115	glycine_N-methyltransferase	58,85	homocysteine	glycine N-methyltransferase	MESH:D006710	25134(Tax:10116)	Chemical	Gene	concentrations|compound|START_ENTITY concentrations|amod|END_ENTITY	Retinoic_acid and glucocorticoid treatment induce hepatic glycine_N-methyltransferase and lower plasma homocysteine concentrations in rats and rat hepatoma cells .
24510388	0	homocysteine	20,32	hCLOCK	36,42	homocysteine	hCLOCK	MESH:D006710	9575	Chemical	Gene	rhythm|nmod|START_ENTITY END_ENTITY|nsubj|rhythm	Circadian rhythm of homocysteine is hCLOCK genotype dependent .
11289481	0	homocysteine	48,60	insulin	10,17	homocysteine	insulin	MESH:D006710	3630	Chemical	Gene	Impact|nmod|START_ENTITY Impact|nmod|resistance resistance|compound|END_ENTITY	Impact of insulin resistance and nephropathy on homocysteine in type 2 diabetes .
12071296	0	homocysteine	69,81	insulin	40,47	homocysteine	insulin	MESH:D006710	3630	Chemical	Gene	START_ENTITY|nsubj|relationship relationship|nmod|resistance resistance|compound|END_ENTITY	Unexpected inverse relationship between insulin resistance and serum homocysteine in healthy subjects .
14758571	0	homocysteine	7,19	insulin	26,33	homocysteine	insulin	MESH:D006710	3630	Chemical	Gene	START_ENTITY|nmod|infusion infusion|compound|END_ENTITY	Plasma homocysteine after insulin infusion in type II diabetic patients with and without methionine intolerance .
15104558	0	homocysteine	7,19	insulin	73,80	homocysteine	insulin	MESH:D006710	3630	Chemical	Gene	correlate|dobj|START_ENTITY correlate|nmod|resistance resistance|compound|END_ENTITY	Plasma homocysteine in polycystic_ovary_syndrome : does it correlate with insulin resistance and ethnicity ?
16772348	0	homocysteine	48,60	insulin	11,18	homocysteine	insulin	MESH:D006710	3630	Chemical	Gene	metabolism|amod|START_ENTITY Effects|nmod|metabolism Effects|nmod|deprivation deprivation|compound|END_ENTITY	Effects of insulin deprivation and treatment on homocysteine metabolism in people with type 1 diabetes .
18686355	0	homocysteine	26,38	insulin	44,51	homocysteine	insulin	MESH:D006710	3630	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	The correlation of plasma homocysteine with insulin resistance in polycystic_ovary_syndrome .
19088160	0	homocysteine	63,75	insulin	11,18	homocysteine	insulin	MESH:D006710	3630	Chemical	Gene	transsulfuration|amod|START_ENTITY Effects|nmod|transsulfuration Effects|nmod|END_ENTITY	Effects of insulin and glucose on cellular metabolic fluxes in homocysteine transsulfuration , remethylation , S-adenosylmethionine synthesis , and global deoxyribonucleic acid methylation .
12964812	0	homocysteine	22,34	interleukin-8	38,51	homocysteine	interleukin-8	MESH:D006710	3576	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|amod|END_ENTITY	Stimulatory effect of homocysteine on interleukin-8 expression in human endothelial cells .
23897788	0	homocysteine	157,169	matrix_metalloproteinase-2	60,86	homocysteine	matrix metalloproteinase-2	MESH:D006710	81686(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY cells|acl|induced vascular|dobj|cells vascular|nsubj|Effects Effects|nmod|rosuvastatin rosuvastatin|nmod|production production|nmod|END_ENTITY	Effects of rosuvastatin on the production and activation of matrix_metalloproteinase-2 and migration of cultured rat vascular smooth muscle cells induced by homocysteine .
25987498	0	homocysteine	121,133	matrix_metalloproteinase-2	80,106	homocysteine	matrix metalloproteinase-2	MESH:D006710	81686(Tax:10116)	Chemical	Gene	involves|nmod|START_ENTITY involves|dobj|modulation modulation|amod|END_ENTITY	Vascular smooth muscle cell differentiation to an osteogenic phenotype involves matrix_metalloproteinase-2 modulation by homocysteine .
10408794	0	homocysteine	33,45	methylenetetrahydrofolate_reductase	64,99	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	enzyme|amod|START_ENTITY mutation|nmod|enzyme Role|nmod|mutation END_ENTITY|nsubj|Role	Role of a common mutation in the homocysteine regulatory enzyme methylenetetrahydrofolate_reductase in ischemic_stroke .
10460200	0	homocysteine	106,118	methylenetetrahydrofolate_reductase	34,69	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	association|nmod|START_ENTITY A1298C|dep|association A1298C|nmod|gene gene|compound|END_ENTITY	A common mutation A1298C in human methylenetetrahydrofolate_reductase gene : association with plasma total homocysteine and folate concentrations .
10704633	0	homocysteine	69,81	methylenetetrahydrofolate_reductase	94,129	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	prevalence|amod|START_ENTITY prevalence|amod|END_ENTITY	Community-living nonagenarians in northern ireland have lower plasma homocysteine but similar methylenetetrahydrofolate_reductase thermolabile genotype prevalence compared to 70-89-year-old subjects .
10817256	0	homocysteine	171,183	methylenetetrahydrofolate_reductase	113,148	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	mutation|nmod|START_ENTITY intervals|dep|mutation intervals|dep|influence influence|nmod|677_C 677_C|amod|END_ENTITY	Non-fasting reference intervals for the Abbott IMx homocysteine and AxSYM plasma folate assays : influence of the methylenetetrahydrofolate_reductase 677_C -- > T mutation on homocysteine .
10817256	0	homocysteine	51,63	methylenetetrahydrofolate_reductase	113,148	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	intervals|nmod|START_ENTITY intervals|dep|influence influence|nmod|677_C 677_C|amod|END_ENTITY	Non-fasting reference intervals for the Abbott IMx homocysteine and AxSYM plasma folate assays : influence of the methylenetetrahydrofolate_reductase 677_C -- > T mutation on homocysteine .
10926884	0	homocysteine	44,56	methylenetetrahydrofolate_reductase	85,120	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	determinant|nmod|START_ENTITY Riboflavin|nmod|determinant Riboflavin|dep|modification modification|nmod|polymorphism polymorphism|amod|END_ENTITY	Riboflavin as a determinant of plasma total homocysteine : effect modification by the methylenetetrahydrofolate_reductase C677T polymorphism .
11101473	0	homocysteine	106,118	methylenetetrahydrofolate_reductase	13,48	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	START_ENTITY|nsubj|Influence Influence|nmod|vitamin_B-12 vitamin_B-12|amod|END_ENTITY	Influence of methylenetetrahydrofolate_reductase genotype , age , vitamin_B-12 , and folate status on plasma homocysteine in children .
11257266	0	homocysteine	130,142	methylenetetrahydrofolate_reductase	22,57	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	levels|compound|START_ENTITY impact|nmod|levels polymorphisms|dep|impact resulting|nmod|polymorphisms genotypes|xcomp|resulting genotypes|nsubj|Identification Identification|nmod|END_ENTITY	Identification of six methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- genotypes resulting from common polymorphisms : impact on plasma homocysteine levels and development of coronary_artery_disease .
11257267	0	homocysteine	100,112	methylenetetrahydrofolate_reductase	56,91	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	levels|amod|START_ENTITY gene|nmod|levels gene|amod|END_ENTITY	The effect of the C677T and A1298C polymorphisms in the methylenetetrahydrofolate_reductase gene on homocysteine levels in elderly men and women from the British regional heart study .
11287760	0	homocysteine	79,91	methylenetetrahydrofolate_reductase	16,51	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	levels|amod|START_ENTITY impact|nmod|levels Polymorphism|dep|impact Polymorphism|nmod|gene gene|amod|END_ENTITY	Polymorphism in methylenetetrahydrofolate_reductase gene : its impact on plasma homocysteine levels and carotid_atherosclerosis in ESRD patients receiving hemodialysis .
11319193	0	homocysteine	77,89	methylenetetrahydrofolate_reductase	21,56	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	START_ENTITY|nsubj|Relation Relation|nmod|mutation mutation|compound|END_ENTITY	Relation of a common methylenetetrahydrofolate_reductase mutation and plasma homocysteine with intimal_hyperplasia after coronary stenting .
11395038	0	homocysteine	116,128	methylenetetrahydrofolate_reductase	30,65	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	vitro|nmod|START_ENTITY END_ENTITY|acl|vitro	The 1298A -- > C polymorphism in methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- : in vitro expression and association with homocysteine .
11508292	0	homocysteine	58,70	methylenetetrahydrofolate_reductase	99,134	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	polymorphism|compound|START_ENTITY polymorphism|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Familial predisposition to ischemic_cardiopathy : role of homocysteine and genetic polymorphism of methylenetetrahydrofolate_reductase -RSB- .
11823591	0	homocysteine	53,65	methylenetetrahydrofolate_reductase	164,199	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	relationship|nmod|START_ENTITY influenced|nsubjpass|relationship influenced|nmod|gene gene|amod|END_ENTITY	The relationship between riboflavin and plasma total homocysteine in the Framingham Offspring cohort is influenced by folate status and the C677T transition in the methylenetetrahydrofolate_reductase gene .
12097662	0	homocysteine	56,68	methylenetetrahydrofolate_reductase	109,144	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	associated|nmod|START_ENTITY associated|nmod|polymorphisms polymorphisms|compound|END_ENTITY	Vitamin_B-12 status is inversely associated with plasma homocysteine in young women with C677T and/or A1298C methylenetetrahydrofolate_reductase polymorphisms .
12204804	0	homocysteine	47,59	methylenetetrahydrofolate_reductase	99,134	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	levels|compound|START_ENTITY levels|acl|associated associated|nmod|mutation mutation|nmod|gene gene|amod|END_ENTITY	Effects of serum B vitamins on elevated plasma homocysteine levels associated with the mutation of methylenetetrahydrofolate_reductase gene in Japanese .
12649066	0	homocysteine	178,190	methylenetetrahydrofolate_reductase	117,152	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	levels|amod|START_ENTITY polymorphism|nmod|levels polymorphism|amod|END_ENTITY	Gene-gene interaction between the cystathionine_beta-synthase 31 base pair variable number of tandem repeats and the methylenetetrahydrofolate_reductase 677C _ > _ T polymorphism on homocysteine levels and risk for neural_tube_defects .
12681883	0	homocysteine	93,105	methylenetetrahydrofolate_reductase	12,47	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	predict|dobj|START_ENTITY predict|nsubj|mutation mutation|compound|END_ENTITY	The 677 C-T methylenetetrahydrofolate_reductase mutation does not predict increased maternal homocysteine during pregnancy .
12687650	0	homocysteine	89,101	methylenetetrahydrofolate_reductase	29,64	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	levels|compound|START_ENTITY total|dobj|levels variant|xcomp|total variant|nsubj|Contribution Contribution|nmod|END_ENTITY	Contribution of thermolabile methylenetetrahydrofolate_reductase variant to total plasma homocysteine levels in healthy men and women .
12797595	0	homocysteine	136,148	methylenetetrahydrofolate_reductase	14,49	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	values|compound|START_ENTITY explained|nmod|values explained|nsubjpass|effect effect|nmod|variant variant|compound|END_ENTITY	The effect of methylenetetrahydrofolate_reductase C677T common variant on hypertensive risk is not solely explained by increased plasma homocysteine values .
14585765	0	homocysteine	90,102	methylenetetrahydrofolate_reductase	35,70	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	level|compound|START_ENTITY genotype|nmod|level genotype|nsubj|dependence dependence|nmod|influence influence|nmod|END_ENTITY	Age dependence of the influence of methylenetetrahydrofolate_reductase genotype on plasma homocysteine level .
14717963	0	homocysteine	176,188	methylenetetrahydrofolate_reductase	29,64	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	levels|amod|START_ENTITY hormones|nmod|levels effect|nmod|hormones levels|dep|effect levels|appos|END_ENTITY	Folate , homocysteine levels , methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- 677C _ -- > _ T variant , and the risk of myocardial_infarction in young women : effect of female hormones on homocysteine levels .
14717963	0	homocysteine	8,20	methylenetetrahydrofolate_reductase	29,64	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Folate , homocysteine levels , methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- 677C _ -- > _ T variant , and the risk of myocardial_infarction in young women : effect of female hormones on homocysteine levels .
15046559	0	homocysteine	80,92	methylenetetrahydrofolate_reductase	16,51	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	levels|compound|START_ENTITY END_ENTITY|nmod|levels	Effect of C677T methylenetetrahydrofolate_reductase gene polymorphism on plasma homocysteine levels in ethnic groups .
15138617	0	homocysteine	119,131	methylenetetrahydrofolate_reductase	4,39	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	increase|nmod|START_ENTITY determinant|nmod|increase determinant|nsubj|polymorphism polymorphism|amod|END_ENTITY	The methylenetetrahydrofolate_reductase C677T polymorphism is a major determinant of coffee-induced increase of plasma homocysteine : a randomized placebo controlled study .
15207432	0	homocysteine	95,107	methylenetetrahydrofolate_reductase	24,59	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	concentrations|compound|START_ENTITY relationships|nmod|concentrations polymorphisms|dep|relationships polymorphisms|nmod|END_ENTITY	Common polymorphisms in methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- : relationships with plasma homocysteine concentrations and cognitive status in elderly northern italian subjects .
15514263	0	homocysteine	86,98	methylenetetrahydrofolate_reductase	147,182	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	concentration|compound|START_ENTITY concentration|acl:relcl|END_ENTITY	Methionine_synthase_reductase 66A - > G polymorphism is associated with increased plasma homocysteine concentration when combined with the homozygous methylenetetrahydrofolate_reductase 677C - > T variant .
15648053	0	homocysteine	69,81	methylenetetrahydrofolate_reductase	18,53	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	START_ENTITY|nsubj|mutation mutation|nmod|gene gene|amod|END_ENTITY	C677T mutation of methylenetetrahydrofolate_reductase gene and serum homocysteine levels in Turkish patients with coronary_artery_disease .
15735067	0	homocysteine	7,19	methylenetetrahydrofolate_reductase	98,133	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	concentrations|compound|START_ENTITY influenced|nsubjpass|concentrations influenced|nmod|interaction interaction|nmod|genotype genotype|amod|END_ENTITY	Plasma homocysteine concentrations in Greek children are influenced by an interaction between the methylenetetrahydrofolate_reductase C677T genotype and folate status .
15777550	0	homocysteine	6,18	methylenetetrahydrofolate_reductase	20,55	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	polymorphism|ccomp|START_ENTITY polymorphism|nsubj|gene gene|amod|END_ENTITY	Serum homocysteine , methylenetetrahydrofolate_reductase gene polymorphism and cardiovascular_disease in heterozygous familial_hypercholesterolemia .
15836661	0	homocysteine	125,137	methylenetetrahydrofolate_reductase	13,48	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	levels|compound|START_ENTITY patients|nmod|levels frequent|nmod|patients frequent|nsubj|genotype genotype|compound|END_ENTITY	Thermolabile methylenetetrahydrofolate_reductase enzyme genotype is frequent in type 2 diabetic patients with normal fasting homocysteine levels .
15912197	0	homocysteine	16,28	methylenetetrahydrofolate_reductase	100,135	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	associated|nsubjpass|START_ENTITY associated|nmod|age age|nmod|mutation mutation|nmod|gene gene|amod|END_ENTITY	Elevated plasma homocysteine is positively associated with age independent of C677T mutation of the methylenetetrahydrofolate_reductase gene in selected Egyptian subjects .
15985285	0	homocysteine	138,150	methylenetetrahydrofolate_reductase	22,57	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	levels|amod|START_ENTITY plasma|dobj|levels polymorphisms|xcomp|plasma polymorphisms|nsubj|Influence Influence|nmod|END_ENTITY	Influence of combined methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- and thymidylate synthase enhancer region -LRB- TSER -RRB- polymorphisms to plasma homocysteine levels in Korean patients with recurrent spontaneous_abortion .
16379339	0	homocysteine	116,128	methylenetetrahydrofolate_reductase	13,48	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	C677T|nmod|START_ENTITY C677T|nsubj|Influence Influence|nmod|END_ENTITY	Influence of methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- C677T polymorphism , B vitamins and other factors on plasma homocysteine and risk of thromboembolic_disease in Chinese .
16999862	0	homocysteine	92,104	methylenetetrahydrofolate_reductase	23,58	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	START_ENTITY|nsubj|power power|nmod|polymorphism polymorphism|amod|END_ENTITY	The screening power of methylenetetrahydrofolate_reductase C677T polymorphism versus plasma homocysteine concentration in patients with stenosis of the internal carotid artery .
17436239	0	homocysteine	122,134	methylenetetrahydrofolate_reductase	4,39	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	metabolism|amod|START_ENTITY effects|nmod|metabolism network|nmod|effects modulator|nmod|network polymorphism|nmod|modulator 677C|dep|polymorphism 677C|amod|END_ENTITY	The methylenetetrahydrofolate_reductase 677C -- > T polymorphism as a modulator of a B vitamin network with major effects on homocysteine metabolism .
18513846	0	homocysteine	72,84	methylenetetrahydrofolate_reductase	14,49	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	polymorphisms|nmod|START_ENTITY polymorphisms|nsubj|Effect Effect|nmod|gene gene|amod|END_ENTITY	Effect of the methylenetetrahydrofolate_reductase gene polymorphisms on homocysteine , folate and vitamin_B12 in patients with bipolar_disorder and relatives .
18580170	0	homocysteine	71,83	methylenetetrahydrofolate_reductase	13,48	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	concentrations|amod|START_ENTITY polymorphisms|nmod|concentrations polymorphisms|nsubj|Influence Influence|nmod|gene gene|amod|END_ENTITY	Influence of methylenetetrahydrofolate_reductase gene polymorphisms on homocysteine concentrations after nitrous_oxide anesthesia .
18586656	0	homocysteine	12,24	methylenetetrahydrofolate_reductase	95,130	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	associated|nsubjpass|START_ENTITY associated|nmod|risk risk|nmod|independent independent|nmod|677C 677C|amod|END_ENTITY	High plasma homocysteine is associated with the risk of coronary_artery_disease independent of methylenetetrahydrofolate_reductase 677C -- > T genotypes .
19093229	0	homocysteine	7,19	methylenetetrahydrofolate_reductase	46,81	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	levels|compound|START_ENTITY levels|appos|prevalence prevalence|nmod|polymorphism polymorphism|amod|END_ENTITY	Plasma homocysteine levels , the prevalence of methylenetetrahydrofolate_reductase gene C677T polymorphism and macrovascular_disorders in systemic_sclerosis : risk factors for accelerated macrovascular damage ?
19211833	0	homocysteine	119,131	methylenetetrahydrofolate_reductase	180,215	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	predict|dobj|START_ENTITY predict|nmod|men men|nmod|genotype genotype|amod|END_ENTITY	Choline intake , plasma riboflavin , and the phosphatidylethanolamine_N-methyltransferase G5465A genotype predict plasma homocysteine in folate-deplete Mexican-American men with the methylenetetrahydrofolate_reductase 677TT genotype .
19804640	0	homocysteine	7,19	methylenetetrahydrofolate_reductase	70,105	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	depends|nsubj|START_ENTITY depends|nmod|interaction interaction|nmod|genotype genotype|amod|END_ENTITY	Plasma homocysteine in adolescents depends on the interaction between methylenetetrahydrofolate_reductase genotype , lipids and folate : a seroepidemiological study .
19934557	0	homocysteine	78,90	methylenetetrahydrofolate_reductase	20,55	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	association|nmod|START_ENTITY association|amod|END_ENTITY	Polymorphism of the methylenetetrahydrofolate_reductase gene association with homocysteine and ischemic_stroke in type 2 diabetes .
20097536	0	homocysteine	88,100	methylenetetrahydrofolate_reductase	14,49	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	concentrations|compound|START_ENTITY Effect|nmod|concentrations Effect|nmod|polymorphism polymorphism|amod|END_ENTITY	Effect of the methylenetetrahydrofolate_reductase -LRB- MTHFR 677C > T -RRB- polymorphism on plasma homocysteine concentrations in healthy children is influenced by consumption of folate-fortified foods .
20421795	0	homocysteine	53,65	methylenetetrahydrofolate_reductase	111,146	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	START_ENTITY|nmod|genotypes genotypes|compound|END_ENTITY	Nutrigenetic impact of daily folate intake on plasma homocysteine and folate levels in patients with different methylenetetrahydrofolate_reductase genotypes .
21104445	0	homocysteine	104,116	methylenetetrahydrofolate_reductase	13,48	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	link|acl|START_ENTITY link|nsubj|Mutations Mutations|acl|END_ENTITY	Mutations in methylenetetrahydrofolate_reductase and in cysthationine beta synthase : is there a link to homocysteine levels in peripheral_arterial_disease ?
21678004	0	homocysteine	106,118	methylenetetrahydrofolate_reductase	19,54	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	levels|amod|START_ENTITY determinant|nmod|levels determinant|nsubj|genotype genotype|nmod|polymorphism polymorphism|amod|END_ENTITY	TT genotype of the methylenetetrahydrofolate_reductase C677T polymorphism is an important determinant for homocysteine levels in multi-ethnic Malaysian ischaemic_stroke patients .
22652272	0	homocysteine	70,82	methylenetetrahydrofolate_reductase	15,50	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	metabolism|amod|START_ENTITY polymorphisms|nmod|metabolism polymorphisms|nsubj|Correlation Correlation|nmod|END_ENTITY	Correlation of methylenetetrahydrofolate_reductase polymorphisms with homocysteine metabolism in healthy Lebanese adults .
23363719	0	homocysteine	90,102	methylenetetrahydrofolate_reductase	43,78	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	START_ENTITY|nsubj|Association Association|nmod|polymorphisms polymorphisms|nmod|END_ENTITY	-LSB- Association between gene polymorphisms of methylenetetrahydrofolate_reductase and plasma homocysteine in Uygur patients with venous_thromboembolism -RSB- .
23866722	0	homocysteine	90,102	methylenetetrahydrofolate_reductase	4,39	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	START_ENTITY|nsubj|polymorphism polymorphism|amod|END_ENTITY	The methylenetetrahydrofolate_reductase polymorphism -LRB- MTHFR c. 677C > T -RRB- and elevated plasma homocysteine levels in a U.S. pediatric population with incident thromboembolism .
25176095	0	homocysteine	91,103	methylenetetrahydrofolate_reductase	44,79	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	START_ENTITY|nsubj|Association Association|nmod|polymorphisms polymorphisms|nmod|END_ENTITY	-LSB- Association of C677T gene polymorphisms of methylenetetrahydrofolate_reductase and plasma homocysteine level with hyperlipidemia -RSB- .
25322900	0	homocysteine	144,156	methylenetetrahydrofolate_reductase	42,77	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	modifies|nmod|START_ENTITY modifies|dobj|effects effects|nmod|polymorphisms polymorphisms|amod|END_ENTITY	Riboflavin status modifies the effects of methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- and methionine_synthase_reductase -LRB- MTRR -RRB- polymorphisms on homocysteine .
9102178	0	homocysteine	93,105	methylenetetrahydrofolate_reductase	40,75	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	START_ENTITY|nsubj|Correlation Correlation|nmod|mutation mutation|nmod|gene gene|amod|END_ENTITY	Correlation of a common mutation in the methylenetetrahydrofolate_reductase gene with plasma homocysteine in patients with premature coronary_artery_disease .
9244205	0	homocysteine	65,77	methylenetetrahydrofolate_reductase	115,150	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	Myocardial_infarction|nmod|START_ENTITY Myocardial_infarction|nmod|gene gene|amod|END_ENTITY	Myocardial_infarction in young women in relation to plasma total homocysteine , folate , and a common variant in the methylenetetrahydrofolate_reductase gene .
9247365	0	homocysteine	102,114	methylenetetrahydrofolate_reductase	29,64	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	levels|compound|START_ENTITY associations|nmod|levels 677C|dep|associations 677C|dep|mutation mutation|nmod|gene gene|amod|END_ENTITY	The 677C -- > T mutation in the methylenetetrahydrofolate_reductase gene : associations with plasma total homocysteine levels and risk of coronary_atherosclerotic_disease .
9349452	0	homocysteine	22,34	methylenetetrahydrofolate_reductase	61,96	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	mutation|compound|START_ENTITY mutation|nmod|gene gene|amod|END_ENTITY	Elevated plasma total homocysteine and C677T mutation of the methylenetetrahydrofolate_reductase gene in patients with spina_bifida .
9543106	0	homocysteine	132,144	methylenetetrahydrofolate_reductase	52,87	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	concentration|compound|START_ENTITY frequency|nmod|concentration polymorphism|dep|frequency polymorphism|nmod|END_ENTITY	C677T -LRB- thermolabile alanine/valine -RRB- polymorphism in methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- : its frequency and impact on plasma homocysteine concentration in different European populations .
9622772	0	homocysteine	79,91	methylenetetrahydrofolate_reductase	33,68	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	onset|amod|START_ENTITY onset|amod|END_ENTITY	Relation of a common mutation in methylenetetrahydrofolate_reductase to plasma homocysteine and early onset coronary_artery_disease .
9680386	0	homocysteine	229,241	methylenetetrahydrofolate_reductase	34,69	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	co-substrate|nmod|START_ENTITY 5-methyltetrahydrofolate|appos|co-substrate 5,10-methylenetetrahydrofolate|nmod|5-methyltetrahydrofolate remethylation|amod|5,10-methylenetetrahydrofolate conversion|nmod|remethylation catalyzes|dobj|conversion catalyzes|nsubj|structure structure|nmod|Methylenetetrahydrofolate_reductase Methylenetetrahydrofolate_reductase|compound|END_ENTITY	Gene structure of human and mouse methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- Methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate , a co-substrate for homocysteine remethylation to methionine .
9863549	0	homocysteine	81,93	methylenetetrahydrofolate_reductase	23,58	homocysteine	methylenetetrahydrofolate reductase	MESH:D006710	4524	Chemical	Gene	levels|nmod|START_ENTITY effect|nmod|levels effect|nmod|mutation mutation|compound|END_ENTITY	The effect of a common methylenetetrahydrofolate_reductase mutation on levels of homocysteine , folate , vitamin_B12 and on the risk of premature_atherosclerosis .
12883331	0	homocysteine	97,109	monocyte_chemoattractant_protein-1	37,71	homocysteine	monocyte chemoattractant protein-1	MESH:D006710	6347	Chemical	Gene	stimulated|nmod|START_ENTITY expression|acl|stimulated expression|amod|END_ENTITY	Intracellular redox status modulates monocyte_chemoattractant_protein-1 expression stimulated by homocysteine in endothelial cells .
10872824	0	homocysteine	15,27	plasminogen_activator_inhibitor-1	31,64	homocysteine	plasminogen activator inhibitor-1	MESH:D006710	5054	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Enhancement by homocysteine of plasminogen_activator_inhibitor-1 gene expression and secretion from vascular endothelial and smooth muscle cells .
1316788	0	homocysteine	24,36	thrombomodulin	67,81	homocysteine	thrombomodulin	MESH:D006710	7056	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	An atherogenic stimulus homocysteine inhibits cofactor activity of thrombomodulin and enhances thrombomodulin expression in human umbilical vein endothelial cells .
18406566	0	homocysteine	18,30	vascular_cell_adhesion_molecule-1	44,77	homocysteine	vascular cell adhesion molecule-1	MESH:D006710	7412	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Priming effect of homocysteine on inducible vascular_cell_adhesion_molecule-1 expression in endothelial cells .
10998075	0	homocysteine	6,18	von_Willebrand_factor	45,66	homocysteine	von Willebrand factor	MESH:D006710	7450	Chemical	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	Serum homocysteine is weakly associated with von_Willebrand_factor and soluble vascular cell adhesion molecule 1 , but not with C-reactive_protein in type 2 diabetic and non-diabetic subjects - The Hoorn Study .
22227865	0	homocysteine_thiolactone	32,56	bleomycin_hydrolase	85,104	homocysteine thiolactone	bleomycin hydrolase	MESH:C007957	104184(Tax:10090)	Chemical	Gene	Metabolism|nmod|START_ENTITY Metabolism|dep|role role|nmod|END_ENTITY	Metabolism and neurotoxicity of homocysteine_thiolactone in mice : protective role of bleomycin_hydrolase .
24148180	0	homoharringtonine	58,75	MiR-370	0,7	homoharringtonine	MiR-370	MESH:C001652	442915	Chemical	Gene	sensitizes|xcomp|START_ENTITY sensitizes|nsubj|END_ENTITY	MiR-370 sensitizes chronic_myeloid_leukemia K562 cells to homoharringtonine by targeting Forkhead_box_M1 .
21152934	0	homoharringtonine	12,29	granulocyte_colony-stimulating_factor	59,96	homoharringtonine	granulocyte colony-stimulating factor	MESH:C001652	1440	Chemical	Gene	dose|nmod|START_ENTITY combined|nsubj|dose combined|nmod|priming priming|amod|END_ENTITY	Low dose of homoharringtonine and cytarabine combined with granulocyte_colony-stimulating_factor priming on the outcome of relapsed or refractory acute_myeloid_leukemia .
24724783	0	homoharringtonine	9,26	granulocyte_colony-stimulating_factor	62,99	homoharringtonine	granulocyte colony-stimulating factor	MESH:C001652	1440	Chemical	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	Low-dose homoharringtonine and cytarabine in combination with granulocyte_colony-stimulating_factor for elderly patients with de novo acute_myeloid_leukemia .
23270584	0	homoharringtonine	47,64	interferon-a	20,32	homoharringtonine	interferon-a	MESH:C001652	3440	Chemical	Gene	combined|nmod|START_ENTITY combined|nsubj|effect effect|nmod|END_ENTITY	Long-term effect of interferon-a combined with homoharringtonine on chronic_myelogenous_leukemia in chronic phase .
11368358	0	homoharringtonine	22,39	p53	52,55	homoharringtonine	p53	MESH:C001652	7157	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Apoptotic response to homoharringtonine in human wt p53 leukemic cells is independent of reactive oxygen species generation and implicates Bax translocation , mitochondrial cytochrome_c release and caspase activation .
12744738	0	homoharringtonine	11,28	telomerase_reverse_transcriptase	52,84	homoharringtonine	telomerase reverse transcriptase	MESH:C001652	7015	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|mRNA mRNA|compound|END_ENTITY	-LSB- Effect of homoharringtonine on expression of human telomerase_reverse_transcriptase mRNA in HL-60 cells -RSB- .
23859260	0	homoisoflavanones	29,46	COX-2	0,5	homoisoflavanones	COX-2	null	4513	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	COX-2 inhibitory activity of homoisoflavanones and xanthones from the bulbs of the Southern African Ledebouria socialis and Ledebouria ovatifolia -LRB- Hyacinthaceae : Hyacinthoideae -RRB- .
12620346	0	homospermidine	35,49	deoxyhypusine_synthase	101,123	homospermidine	deoxyhypusine synthase	CHEBI:16554	1725	Chemical	Gene	Evidence|nmod|START_ENTITY Evidence|nmod|END_ENTITY	Evidence for general occurrence of homospermidine in plants and its supposed origin as by-product of deoxyhypusine_synthase .
6163366	0	homovanillic_acid	60,77	CSF	56,59	homovanillic acid	CSF	MESH:D006719	1437	Chemical	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	Relationship between estimated premorbid adjustment and CSF homovanillic_acid and 5-hydroxyindoleacetic_acid levels .
12101784	0	homovanillic_acid	8,25	prolactin	36,45	homovanillic acid	prolactin	MESH:D006719	5617	Chemical	Gene	START_ENTITY|dobj|levels levels|compound|END_ENTITY	Urinary homovanillic_acid and serum prolactin levels in children with low environmental exposure to lead .
27086914	0	homovanillyl_sinapate	22,43	c-Met	55,60	homovanillyl sinapate	c-Met	null	4233	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|amod|END_ENTITY	The oleocanthal-based homovanillyl_sinapate as a novel c-Met inhibitor .
23877711	0	honokiol	29,37	specificity_protein_1	88,109	honokiol	specificity protein 1	MESH:C005499	6667	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|regulation regulation|nmod|END_ENTITY	Anti-proliferative effect of honokiol in oral_squamous_cancer through the regulation of specificity_protein_1 .
21783979	0	hopeahainol_A	21,34	acetylcholinesterase	44,64	hopeahainol A	acetylcholinesterase	MESH:C526863	83817(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Protective effect of hopeahainol_A , a novel acetylcholinesterase inhibitor , on hydrogen_peroxide-induced injury in PC12 cells .
25073399	0	huperzine_A	29,40	CYP3A4	19,25	huperzine A	CYP3A4	MESH:C050426	1576	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of human CYP3A4 by huperzine_A , ligustrazine and oridonin through pregnane_X_receptor-mediated pathways .
10423544	0	huperzine_A	64,75	acetylcholinesterase	28,48	huperzine A	acetylcholinesterase	MESH:C050426	11423(Tax:10090)	Chemical	Gene	complexed|nmod|START_ENTITY complexed|nsubj|dynamics dynamics|nmod|END_ENTITY	Molecular dynamics of mouse acetylcholinesterase complexed with huperzine_A .
12445575	0	huperzine_A	11,22	acetylcholinesterase	26,46	huperzine A	acetylcholinesterase	MESH:C050426	83817(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|isoforms isoforms|amod|END_ENTITY	Effects of huperzine_A on acetylcholinesterase isoforms in vitro : comparison with tacrine , donepezil , rivastigmine and physostigmine .
1800123	0	huperzine_A	52,63	acetylcholinesterase	95,115	huperzine A	acetylcholinesterase	MESH:C050426	83817(Tax:10116)	Chemical	Gene	enantiomers|nmod|START_ENTITY Potencies|nmod|enantiomers END_ENTITY|nsubj|Potencies	Potencies and stereoselectivities of enantiomers of huperzine_A for inhibition of rat cortical acetylcholinesterase .
18572153	0	huperzine_A	58,69	acetylcholinesterase	150,170	huperzine A	acetylcholinesterase	MESH:C050426	43	Chemical	Gene	acetylcholinesterase|nmod|START_ENTITY Protection|nmod|acetylcholinesterase Protection|dep|prophylaxis prophylaxis|nmod|END_ENTITY	Protection of red blood cell acetylcholinesterase by oral huperzine_A against ex vivo soman exposure : next generation prophylaxis and sequestering of acetylcholinesterase over butyrylcholinesterase .
23403922	0	huperzine_A	15,26	acetylcholinesterase	47,67	huperzine A	acetylcholinesterase	MESH:C050426	11423(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nsubj|effects	The effects of huperzine_A on gastrointestinal acetylcholinesterase activity and motility after single and multiple dosing in mice .
12904285	0	huperzine_A	11,22	cytochrome_P-450	32,48	huperzine A	cytochrome P-450	MESH:C050426	25251(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of huperzine_A on liver cytochrome_P-450 in rats .
15916732	0	huperzine_A	11,22	nerve_growth_factor	39,58	huperzine A	nerve growth factor	MESH:C050426	310738(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of huperzine_A on secretion of nerve_growth_factor in cultured rat cortical astrocytes and neurite outgrowth in rat PC12 cells .
12517147	0	huperzine_a	64,75	Acetylcholinesterase	0,20	huperzine a	Acetylcholinesterase	MESH:C050426	83817(Tax:10116)	Chemical	Gene	related|nmod|START_ENTITY ligands|acl|related complexed|nmod|ligands END_ENTITY|acl|complexed	Acetylcholinesterase complexed with bivalent ligands related to huperzine_a : experimental evidence for species-dependent protein-ligand complementarity .
20363245	0	huprine_X	59,68	PKCalpha	38,46	huprine X	PKCalpha	MESH:C404518	18750(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Behavioural effects and regulation of PKCalpha and MAPK by huprine_X in middle aged mice .
10465577	0	hyaluronate	87,98	CD44	0,4	hyaluronate	CD44	CHEBI:16336	960	Chemical	Gene	upregulated|nmod|START_ENTITY upregulated|nsubjpass|expression expression|nummod|END_ENTITY	CD44 variant isoform CD44v10 expression of human melanoma cell lines is upregulated by hyaluronate and correlates with migration .
10529137	0	hyaluronate	11,22	CD44	26,30	hyaluronate	CD44	CHEBI:16336	25406(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of hyaluronate on CD44 expression of infiltrating cells in exudate of rat air pouch , induced by sensitization with lipopolysaccharide .
11121141	0	hyaluronate	76,87	CD44	22,26	hyaluronate	CD44	CHEBI:16336	960	Chemical	Gene	accumulation|compound|START_ENTITY mechanism|nmod|accumulation expression|nmod|mechanism expression|compound|END_ENTITY	Decrease in epidermal CD44 expression as a potential mechanism for abnormal hyaluronate accumulation in superficial dermis in lichen sclerosus et atrophicus .
1694723	0	hyaluronate	48,59	CD44	0,4	hyaluronate	CD44	CHEBI:16336	960	Chemical	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	CD44 is the principal cell surface receptor for hyaluronate .
1719988	1	hyaluronate	120,131	CD44	133,137	hyaluronate	CD44	CHEBI:16336	960	Chemical	Gene	receptor|nmod|START_ENTITY Up-regulation|nmod|receptor Up-regulation|appos|END_ENTITY	Up-regulation of the receptor for hyaluronate -LRB- CD44 -RRB- in rheumatoid_arthritis .
2193100	0	hyaluronate	78,89	CD44	57,61	hyaluronate	CD44	CHEBI:16336	960	Chemical	Gene	recognition|amod|START_ENTITY participates|nmod|recognition participates|nsubj|END_ENTITY	Hyaluronate can function as a cell adhesion molecule and CD44 participates in hyaluronate recognition .
22770970	0	hyaluronate	94,105	CD44	67,71	hyaluronate	CD44	CHEBI:16336	960	Chemical	Gene	receptors|nmod|START_ENTITY receptors|amod|END_ENTITY	Oropharyngeal malignant epithelial cell , lymphocyte and macrophage CD44 surface receptors for hyaluronate are expressed in sustained EBV_infection : immunohistochemical data and EBV DNA tissue indices .
8429233	0	hyaluronate	37,48	CD44	63,67	hyaluronate	CD44	CHEBI:16336	960	Chemical	Gene	cells|nmod|START_ENTITY Migration|nmod|cells related|nsubjpass|Migration related|nmod|expression expression|compound|END_ENTITY	Migration of human melanoma cells on hyaluronate is related to CD44 expression .
8570172	0	hyaluronate	5,16	CD44	0,4	hyaluronate	CD44	CHEBI:16336	960	Chemical	Gene	binding|amod|START_ENTITY END_ENTITY|amod|binding	CD44 hyaluronate binding influences growth kinetics and tumorigenicity of human colon_carcinomas .
8621620	0	hyaluronate	59,70	CD44	32,36	hyaluronate	CD44	CHEBI:16336	960	Chemical	Gene	adhesion|xcomp|START_ENTITY adhesion|nsubj|modification modification|nmod|modulates modulates|nummod|END_ENTITY	Keratan sulfate modification of CD44 modulates adhesion to hyaluronate .
8769429	1	hyaluronate	105,116	CD44	132,136	hyaluronate	CD44	CHEBI:16336	960	Chemical	Gene	START_ENTITY|acl|shedding shedding|nmod|END_ENTITY	I. De-adhesion from hyaluronate by shedding of CD44 .
8858111	0	hyaluronate	49,60	CD44	32,36	hyaluronate	CD44	CHEBI:16336	960	Chemical	Gene	modifies|xcomp|START_ENTITY modifies|dobj|adhesion adhesion|compound|END_ENTITY	O-linked glycosylation modifies CD44 adhesion to hyaluronate in colon_carcinoma cells .
9102228	2	hyaluronate	239,250	CD44	208,212	hyaluronate	CD44	CHEBI:16336	960	Chemical	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	CD44 is the major receptor for hyaluronate -LRB- HA -RRB- , a component of cell matrices , and most of CD44 known functions are attributed to its ability to recognize HA .
9399665	0	hyaluronate	64,75	CD44	33,37	hyaluronate	CD44	CHEBI:16336	12505(Tax:10090)	Chemical	Gene	growth|compound|START_ENTITY enhances|nmod|growth enhances|nsubj|Remodeling Remodeling|nmod|glycoconjugates glycoconjugates|nmod|END_ENTITY	Remodeling of glycoconjugates on CD44 enhances cell adhesion to hyaluronate , tumor growth and metastasis in B16 melanoma cells expressing beta1,4-N-acetylglucosaminyltransferase III .
9622073	0	hyaluronate	109,120	CD44	39,43	hyaluronate	CD44	CHEBI:16336	25406(Tax:10116)	Chemical	Gene	the|acl|START_ENTITY require|dobj|the require|nsubj|suppression suppression|nmod|isoform isoform|compound|END_ENTITY	Metastasis suppression by the standard CD44 isoform does not require the binding of prostate_cancer cells to hyaluronate .
8353136	0	hyaluronate	14,25	interleukin_1	40,53	hyaluronate	interleukin 1	CHEBI:16336	3552	Chemical	Gene	production|amod|START_ENTITY Regulation|nmod|production Regulation|nmod|END_ENTITY	Regulation of hyaluronate production by interleukin_1 in cultured human chorionic cells .
26505972	0	hyaluronic_acid	22,37	CD44	0,4	hyaluronic acid	CD44	MESH:D006820	12505(Tax:10090)	Chemical	Gene	regulation|amod|START_ENTITY regulation|compound|END_ENTITY	CD44 and TLR4 mediate hyaluronic_acid regulation of Lgr5 + stem cell proliferation , crypt fission , and intestinal growth in postnatal and adult mice .
11121595	0	hyaluronic_acid	84,99	Endothelin-1	0,12	hyaluronic acid	Endothelin-1	MESH:D006820	13614(Tax:10090)	Chemical	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	Endothelin-1 is involved in the growth promotion of vascular smooth muscle cells by hyaluronic_acid .
11775838	0	hyaluronic_acid	60,75	IFN-gamma	10,19	hyaluronic acid	IFN-gamma	MESH:D006820	3458	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of IFN-gamma , IL-4 on proliferation and synthesis of hyaluronic_acid and collagen in cultured human retroorbital fibroblasts in vitro .
5914246	0	hyaluronic_acid	17,32	hyaluronidase	103,116	hyaluronic acid	hyaluronidase	MESH:D006820	396998(Tax:9823)	Chemical	Gene	isolation|nmod|START_ENTITY isolation|nmod|END_ENTITY	The isolation of hyaluronic_acid and chondroitin_sulphate from kidneys and their reaction with urinary hyaluronidase .
19302997	0	hyaluronic_acid	54,69	mesothelin	6,16	hyaluronic acid	mesothelin	MESH:D006820	10232	Chemical	Gene	has|nmod|START_ENTITY has|nsubj|END_ENTITY	Serum mesothelin has a higher diagnostic utility than hyaluronic_acid in malignant_mesothelioma .
25595683	0	hyattellactones_A_and_B	52,75	protein_tyrosine_phosphatase_1B	8,39	hyattellactones A and B	protein tyrosine phosphatase 1B	null	5770	Chemical	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Two new protein_tyrosine_phosphatase_1B inhibitors , hyattellactones_A_and_B , from the Indonesian marine sponge Hyattella sp .
8998407	0	hydergine	15,24	MAO	32,35	hydergine	MAO	MESH:D004877	29253(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activity activity|compound|END_ENTITY	The effects of hydergine on the MAO activity of the aged and adult rat brain .
1829659	0	hydralazine	117,128	Atrial_natriuretic_factor	0,25	hydralazine	Atrial natriuretic factor	MESH:D006830	24602(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY effect|nmod|treatment release|dep|effect release|amod|END_ENTITY	Atrial_natriuretic_factor release during volume expansion in the spontaneously hypertensive rat -- effect of long-term hydralazine treatment .
17357303	0	hydralazine	10,21	CD3-zeta_chain	25,39	hydralazine	CD3-zeta chain	MESH:D006830	919	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of hydralazine on CD3-zeta_chain expression in Jurkat T cells .
9595450	0	hydralazine	47,58	Endothelin-A_receptor	0,21	hydralazine	Endothelin-A receptor	MESH:D006830	24326(Tax:10116)	Chemical	Gene	antagonist|nmod|START_ENTITY antagonist|amod|END_ENTITY	Endothelin-A_receptor antagonist combined with hydralazine improves survival and renal function in hypertensive rats .
12970383	0	hydralazine	60,71	Semicarbazide-sensitive_amine_oxidase	0,37	hydralazine	Semicarbazide-sensitive amine oxidase	MESH:D006830	29473(Tax:10116)	Chemical	Gene	hypotension|compound|START_ENTITY substrates|dep|hypotension substrates|amod|END_ENTITY	Semicarbazide-sensitive_amine_oxidase substrates potentiate hydralazine hypotension : possible role of hydrogen_peroxide .
1545080	0	hydralazine	35,46	angiotensin-converting_enzyme	54,83	hydralazine	angiotensin-converting enzyme	MESH:D006830	1636	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|amod|END_ENTITY	Effect of direct vasodilation with hydralazine versus angiotensin-converting_enzyme inhibition with captopril on mortality in advanced heart_failure : the Hy-C trial .
2833897	0	hydralazine	109,120	atrial_natriuretic_factor	125,150	hydralazine	atrial natriuretic factor	MESH:D006830	24602(Tax:10116)	Chemical	Gene	Effects|amod|START_ENTITY Effects|nmod|END_ENTITY	Effects of chronic treatment with a novel angiotensin converting enzyme inhibitor , CS622 , and a vasodilator , hydralazine , on atrial_natriuretic_factor -LRB- ANF -RRB- in spontaneously hypertensive rats -LRB- SHR -RRB- .
1848881	0	hydralazine	117,128	myeloperoxidase	37,52	hydralazine	myeloperoxidase	MESH:D006830	4353	Chemical	Gene	due|xcomp|START_ENTITY glomerulonephritis|amod|due responses|nmod|glomerulonephritis Antibodies|dep|responses Antibodies|nmod|granulocyte granulocyte|amod|END_ENTITY	Antibodies to neutrophil granulocyte myeloperoxidase and elastase : autoimmune responses in glomerulonephritis due to hydralazine treatment .
7946512	0	hydralazine	100,111	myeloperoxidase	46,61	hydralazine	myeloperoxidase	MESH:D006830	4353	Chemical	Gene	treated|nmod|START_ENTITY patients|acl|treated directed|nmod|patients directed|nmod|END_ENTITY	Occurrence of autoantibodies directed against myeloperoxidase and elastase in patients treated with hydralazine and presenting with glomerulonephritis .
8248010	0	hydralazine	93,104	myeloperoxidase	15,30	hydralazine	myeloperoxidase	MESH:D006830	4353	Chemical	Gene	START_ENTITY|nsubj|Interaction Interaction|nmod|activity activity|amod|END_ENTITY	Interaction of myeloperoxidase and elastase enzyme activity with the antihypertensive agents hydralazine and dihydralazine .
4091799	0	hydralazine	19,30	semicarbazide-sensitive_amine_oxidase	38,75	hydralazine	semicarbazide-sensitive amine oxidase	MESH:D006830	29473(Tax:10116)	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	The interaction of hydralazine with a semicarbazide-sensitive_amine_oxidase in brown adipose tissue of the rat .
8576911	0	hydrazine	71,80	gamma-aminobutyric_acid_aminotransferase	27,67	hydrazine	gamma-aminobutyric acid aminotransferase	MESH:C029424	18	Chemical	Gene	analogues|amod|START_ENTITY inhibition|nmod|analogues inhibition|nmod|END_ENTITY	Slow-binding inhibition of gamma-aminobutyric_acid_aminotransferase by hydrazine analogues .
7394777	0	hydrazine	11,20	ornithine_decarboxylase	44,67	hydrazine	ornithine decarboxylase	MESH:C029424	4953	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|synthesis synthesis|amod|END_ENTITY	Effects of hydrazine and its derivatives on ornithine_decarboxylase synthesis , activity , and inactivation .
20690686	0	hydrazine	106,115	vascular_adhesion_protein-1	136,163	hydrazine	vascular adhesion protein-1	MESH:C029424	8639	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|nmod|END_ENTITY	Synthesis , in vitro activity , and three-dimensional quantitative structure-activity relationship of novel hydrazine inhibitors of human vascular_adhesion_protein-1 .
6873062	0	hydrazines	28,38	cytochrome_P450	67,82	hydrazines	cytochrome P450	MESH:D006834	25251(Tax:10116)	Chemical	Gene	Reaction|nmod|START_ENTITY Reaction|nmod|END_ENTITY	Reaction of monosubstituted hydrazines and diazenes with rat-liver cytochrome_P450 .
3007460	0	hydrazines	62,72	dopamine_beta-hydroxylase	33,58	hydrazines	dopamine beta-hydroxylase	MESH:D006834	1621	Chemical	Gene	mechanism|nmod|START_ENTITY mechanism|nmod|END_ENTITY	The mechanism of inactivation of dopamine_beta-hydroxylase by hydrazines .
21570309	0	hydrazone	60,69	COX-2	108,113	hydrazone	COX-2	CHEBI:38532	26198(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Design , synthesis , and biological evaluation of substituted hydrazone and pyrazole derivatives as selective COX-2 inhibitors : Molecular docking study .
12814621	0	hydrazone	91,100	tyrosinase	50,60	hydrazone	tyrosinase	CHEBI:38532	7299	Chemical	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	Quantification of acetaminophen by oxidation with tyrosinase in the presence of Besthorn 's hydrazone .
20579890	0	hydrazothiazole	82,97	monoamine_oxidase_B	119,138	hydrazothiazole	monoamine oxidase B	null	4129	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|inhibitors inhibitors|compound|END_ENTITY	Synthesis , semipreparative HPLC_separation , biological evaluation , and 3D-QSAR of hydrazothiazole derivatives as human monoamine_oxidase_B inhibitors .
23420416	0	hydride	109,116	dihydrofolate_reductase	138,161	hydride	dihydrofolate reductase	CHEBI:29239	13906554	Chemical	Gene	reaction|amod|START_ENTITY reaction|nmod|END_ENTITY	Multiple intermediates , diverse conformations , and cooperative conformational changes underlie the catalytic hydride transfer reaction of dihydrofolate_reductase .
21709869	0	hydrocarbon	57,68	C18	53,56	hydrocarbon	C18	CHEBI:24632	27241	Chemical	Gene	chains|compound|START_ENTITY chains|compound|END_ENTITY	Nonionic diethanolamide amphiphiles with unsaturated C18 hydrocarbon chains : thermotropic and lyotropic liquid crystalline phase behavior .
1941434	0	hydrocarbon	66,77	cyclosporin_A	161,174	hydrocarbon	cyclosporin A	CHEBI:24632	1161	Chemical	Gene	chains|compound|START_ENTITY chains|nmod|END_ENTITY	Liposomes as cyclosporin_A carriers : the influence of ordering of hydrocarbon chains of phosphatidylglycerol liposomes on the association with and topography of cyclosporin_A .
2097282	0	hydrocarbon	91,102	cytochrome_P-450	16,32	hydrocarbon	cytochrome P-450	CHEBI:24632	25251(Tax:10116)	Chemical	Gene	-RSB-|compound|START_ENTITY Specificity|nmod|-RSB- Specificity|nmod|forms forms|amod|END_ENTITY	-LSB- Specificity of cytochrome_P-450 forms in the rat liver after inhalation of multicomponent hydrocarbon mixture -RSB- .
3406035	0	hydrocarbon	28,39	cytochrome_P-450	8,24	hydrocarbon	cytochrome P-450	CHEBI:24632	4051	Chemical	Gene	formation|compound|START_ENTITY END_ENTITY|nmod|formation	Role of cytochrome_P-450 in hydrocarbon formation from xenobiotic and lipid hydroperoxides .
17360514	0	hydrocarbon	58,69	elongase	26,34	hydrocarbon	elongase	CHEBI:24632	41211(Tax:7227)	Chemical	Gene	biosynthesis|compound|START_ENTITY involved|nmod|biosynthesis END_ENTITY|acl|involved	A female-biased expressed elongase involved in long-chain hydrocarbon biosynthesis and courtship_behavior in Drosophila_melanogaster .
517011	0	hydrocarbons	37,49	cytochrome_P-450	15,31	hydrocarbons	cytochrome P-450	MESH:D006838	25251(Tax:10116)	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of cytochrome_P-450 with hydrocarbons .
6141956	0	hydrochloric_acid	35,52	somatostatin	11,23	hydrochloric acid	somatostatin	MESH:D006851	403993(Tax:9615)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	-LSB- Effect of somatostatin on gastric hydrochloric_acid secretion and serum gastrin concentration in the dog -RSB- .
9643274	0	hydrochlorothiazide	179,198	ACE	136,139	hydrochlorothiazide	ACE	MESH:D006852	1636	Chemical	Gene	inhibitor|nmod|START_ENTITY inhibitor|compound|END_ENTITY	Antihypertensive treatment in postmenopausal women : results from a prospective , randomized , double-blind , controlled study comparing an ACE inhibitor -LRB- moexipril -RRB- with a diuretic -LRB- hydrochlorothiazide -RRB- .
15781471	0	hydrochlorothiazide	73,92	NaCl-cotransporter	19,37	hydrochlorothiazide	NaCl-cotransporter	MESH:D006852	6559	Chemical	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Thiazide-sensitive NaCl-cotransporter in the intestine : possible role of hydrochlorothiazide in the intestinal Ca2 + uptake .
17143194	0	hydrochlorothiazide	106,125	Renin	0,5	hydrochlorothiazide	Renin	MESH:D006852	5972	Chemical	Gene	used|nmod|START_ENTITY provides|advcl|used provides|nsubj|inhibition inhibition|compound|END_ENTITY	Renin inhibition with aliskiren provides additive antihypertensive efficacy when used in combination with hydrochlorothiazide .
26142561	0	hydrochlorothiazide	181,200	albumin	142,149	hydrochlorothiazide	albumin	MESH:D006852	213	Chemical	Gene	absence|nmod|START_ENTITY END_ENTITY|nmod|absence	Application of capillary electrophoresis-frontal analysis for comparative evaluation of the binding interaction of captopril with human serum albumin in the absence and presence of hydrochlorothiazide .
9360571	0	hydrochlorothiazide	68,87	angiotensin-converting_enzyme	91,120	hydrochlorothiazide	angiotensin-converting enzyme	MESH:D006852	1636	Chemical	Gene	START_ENTITY|nmod|therapy therapy|amod|END_ENTITY	Rapid life-threatening hyperkalemia after addition of amiloride_HCl / hydrochlorothiazide to angiotensin-converting_enzyme inhibitor therapy .
2857210	0	hydrochlorothiazide	55,74	insulin	118,125	hydrochlorothiazide	insulin	MESH:D006852	3630	Chemical	Gene	effect|nmod|START_ENTITY propranolol|nmod|effect Aggravation|nmod|propranolol Aggravation|nmod|alteration alteration|nmod|secretion secretion|compound|END_ENTITY	Aggravation by propranolol of hyperglycaemic effect of hydrochlorothiazide in type II diabetics without alteration of insulin secretion .
7794577	0	hydrochlorothiazide	41,60	insulin	64,71	hydrochlorothiazide	insulin	MESH:D006852	3630	Chemical	Gene	START_ENTITY|nmod|sensitivity sensitivity|compound|END_ENTITY	The effect of enalapril with and without hydrochlorothiazide on insulin sensitivity and other metabolic_abnormalities of hypertensive patients with NIDDM .
6756696	0	hydrochlorothiazide	90,109	kallikrein	45,55	hydrochlorothiazide	kallikrein	MESH:D006852	9622	Chemical	Gene	administration|amod|START_ENTITY END_ENTITY|nmod|administration	Plasma active and inactive renin and urinary kallikrein in normal subjects in response to hydrochlorothiazide , spironolactone or aldosterone administration .
8082049	0	hydrochlorothiazide	73,92	parathyroid_hormone	36,55	hydrochlorothiazide	parathyroid hormone	MESH:D006852	5741	Chemical	Gene	action|nmod|START_ENTITY END_ENTITY|nmod|action	The modulatory effect of endogenous parathyroid_hormone on the action of hydrochlorothiazide in pseudohypoparathyroidism_type_I .
1002400	0	hydrochlorothiazide	73,92	renin	15,20	hydrochlorothiazide	renin	MESH:D006852	5972	Chemical	Gene	results|nmod|START_ENTITY Stimulation|dep|results Stimulation|nmod|secretion secretion|compound|END_ENTITY	Stimulation of renin secretion by various methods : optional results with hydrochlorothiazide .
17073832	0	hydrochlorothiazide	167,186	renin	66,71	hydrochlorothiazide	renin	MESH:D006852	5972	Chemical	Gene	Lack|appos|START_ENTITY Lack|appos|inhibitor inhibitor|compound|END_ENTITY	Lack of pharmacokinetic interactions of aliskiren , a novel direct renin inhibitor for the treatment of hypertension , with the antihypertensives amlodipine , valsartan , hydrochlorothiazide -LRB- HCTZ -RRB- and ramipril in healthy volunteers .
19139391	0	hydrochlorothiazide	151,170	renin	66,71	hydrochlorothiazide	renin	MESH:D006852	5972	Chemical	Gene	trial|nmod|START_ENTITY efficacy|dep|trial efficacy|nmod|aliskiren aliskiren|compound|END_ENTITY	Long-term antihypertensive efficacy and safety of the oral direct renin inhibitor aliskiren : a 12-month randomized , double-blind comparator trial with hydrochlorothiazide .
22035463	0	hydrochlorothiazide	100,119	renin	53,58	hydrochlorothiazide	renin	MESH:D006852	5972	Chemical	Gene	aliskiren|nmod|START_ENTITY aliskiren|compound|END_ENTITY	Long-term safety and tolerability of the oral direct renin inhibitor aliskiren with optional add-on hydrochlorothiazide in patients with hypertension : a randomized , open-label , parallel-group , multicentre , dose-escalation study with an extension phase .
234821	0	hydrochlorothiazide	46,65	renin	95,100	hydrochlorothiazide	renin	MESH:D006852	403838(Tax:9615)	Chemical	Gene	START_ENTITY|nmod|dogs dogs|nmod|suppression suppression|nmod|END_ENTITY	Enhancement of the antihypertensive effect of hydrochlorothiazide in dogs after suppression of renin release by beta-adrenergic blockade .
282043	0	hydrochlorothiazide	34,53	renin	15,20	hydrochlorothiazide	renin	MESH:D006852	5972	Chemical	Gene	responses|nmod|START_ENTITY responses|compound|END_ENTITY	Acid-activated renin responses to hydrochlorothiazide , propranol and indomethacin .
883759	0	hydrochlorothiazide	65,84	renin	7,12	hydrochlorothiazide	renin	MESH:D006852	5972	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|activity activity|compound|END_ENTITY	Plasma renin activity in pregnant women with oedema treated with hydrochlorothiazide .
9103485	0	hydrocodone	48,59	cytochrome_P450_2D6	14,33	hydrocodone	cytochrome P450 2D6	MESH:D006853	1565	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|amod|END_ENTITY	Inhibition of cytochrome_P450_2D6 metabolism of hydrocodone to hydromorphone does not importantly affect abuse liability .
186258	0	hydrocortisone	52,66	ACTH	23,27	hydrocortisone	ACTH	MESH:D006854	5443	Chemical	Gene	infusion|amod|START_ENTITY immunoassayable|nmod|infusion immunoassayable|dobj|levels levels|compound|END_ENTITY	Plasma immunoassayable ACTH levels during and after hydrocortisone infusion in patients with Cushing 's _ disease .
27025241	0	hydrocortisone	9,23	ACTH	150,154	hydrocortisone	ACTH	MESH:D006854	5443	Chemical	Gene	replacement|compound|START_ENTITY associated|nsubjpass|replacement associated|nmod|patients patients|amod|adrenocorticotropin adrenocorticotropin|dep|END_ENTITY	Low dose hydrocortisone replacement is associated with improved arterial stiffness index and blood pressure dynamics in severely adrenocorticotropin -LRB- ACTH -RRB- deficient_hypopituitary_male patients .
4308123	0	hydrocortisone	17,31	ACTH	11,15	hydrocortisone	ACTH	MESH:D006854	5443	Chemical	Gene	START_ENTITY|nsubj|Action Action|nmod|END_ENTITY	-LSB- Action of ACTH , hydrocortisone and prednisolone on human erythrocytic angiotensinase in vitro -RSB- .
6244198	0	hydrocortisone	24,38	ACTH	90,94	hydrocortisone	ACTH	MESH:D006854	5443	Chemical	Gene	ointments|amod|START_ENTITY effects|nmod|ointments Study|nmod|effects END_ENTITY|nsubj|Study	Study of the effects of hydrocortisone and hydrocortisone_17-butyrate ointments on plasma ACTH levels and Synacthen responses in children with eczema .
6259040	0	hydrocortisone	10,24	ACTH	28,32	hydrocortisone	ACTH	MESH:D006854	5443	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of hydrocortisone on ACTH , growth_hormone , insulin and glucose in the blood of bilaterally adrenalectomized patients .
15647850	0	hydrocortisone	10,24	CXCL8	79,84	hydrocortisone	CXCL8	MESH:D006854	3576	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|nmod|END_ENTITY	High-dose hydrocortisone reduces expression of the pro-inflammatory chemokines CXCL8 and CXCL10 in SARS_coronavirus-infected intestinal cells .
10772626	0	hydrocortisone	33,47	CYP3A4	18,24	hydrocortisone	CYP3A4	MESH:D006854	1576	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Regulation of the CYP3A4 gene by hydrocortisone and xenobiotics : role of the glucocorticoid and pregnane_X_receptors .
8796136	0	hydrocortisone	105,119	Growth_hormone	0,14	hydrocortisone	Growth hormone	MESH:D006854	2688	Chemical	Gene	therapy|amod|START_ENTITY circulating|nmod|therapy reduces|xcomp|circulating reduces|nsubj|treatment treatment|amod|END_ENTITY	Growth_hormone treatment in hypopituitary_GH_deficient adults reduces circulating cortisol levels during hydrocortisone replacement therapy .
13130151	0	hydrocortisone	112,126	HAS1	136,140	hydrocortisone	HAS1	MESH:D006854	3036	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|compound|END_ENTITY	Glucocorticoids inhibit induced and non-induced mRNA accumulation of genes encoding hyaluronan_synthases -LRB- HAS -RRB- : hydrocortisone inhibits HAS1 activation by blocking the p38_mitogen-activated_protein_kinase signalling pathway .
16772320	0	hydrocortisone	30,44	Insulin	0,7	hydrocortisone	Insulin	MESH:D006854	3630	Chemical	Gene	induced|nmod|START_ENTITY resistance|acl|induced resistance|compound|END_ENTITY	Insulin resistance induced by hydrocortisone is increased in patients with abdominal_obesity .
6269518	0	hydrocortisone	11,25	KOX-1	78,83	hydrocortisone	KOX-1	MESH:D006854	50490(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	-LSB- Effect of hydrocortisone on alpha-glycerophosphate dehydrogenase activity in KOX-1 and mouse_glioblastoma EPNT-5 cells -RSB- .
5475638	0	hydrocortisone	48,62	Neuraminidase	0,13	hydrocortisone	Neuraminidase	MESH:D006854	4758	Chemical	Gene	effect|nmod|START_ENTITY activity|dep|effect activity|amod|END_ENTITY	Neuraminidase activity in hela cells : effect of hydrocortisone .
964321	0	hydrocortisone	80,94	Parathyroid_hormone	0,19	hydrocortisone	Parathyroid hormone	MESH:D006854	5741	Chemical	Gene	activity|nmod|START_ENTITY induction|nmod|activity inhibition|nmod|induction inhibition|amod|END_ENTITY	Parathyroid_hormone inhibition of induction of alkaline phosphatase activity by hydrocortisone and 5-iodo-2 ' - deoxyuridine in HeLa cells .
5903340	0	hydrocortisone	47,61	Tryptophan_pyrrolase	0,20	hydrocortisone	Tryptophan pyrrolase	MESH:D006854	6999	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Tryptophan_pyrrolase induced in human liver by hydrocortisone : effect on excretion of kynurenine .
1664103	0	hydrocortisone	11,25	angiotensin_converting_enzyme	29,58	hydrocortisone	angiotensin converting enzyme	MESH:D006854	24310(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	-LSB- Effect of hydrocortisone on angiotensin_converting_enzyme activity in the rat lungs -RSB- .
9777194	0	hydrocortisone	41,55	apolipoprotein_E	59,75	hydrocortisone	apolipoprotein E	MESH:D006854	348	Chemical	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	-LSB- Effect of high density lipoproteins and hydrocortisone on apolipoprotein_E production in Kupffer cells -RSB- .
6310920	0	hydrocortisone	81,95	beta-endorphin	46,60	hydrocortisone	beta-endorphin	MESH:D006854	5443	Chemical	Gene	induced|nmod|START_ENTITY induced|dobj|release release|amod|END_ENTITY	Suppression of electroacupuncture -LRB- EA -RRB- - induced beta-endorphin and ACTH release by hydrocortisone in man .
2456099	0	hydrocortisone	15,29	c-fos	33,38	hydrocortisone	c-fos	MESH:D006854	2353	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|amod|END_ENTITY	The effects of hydrocortisone on c-fos , c-myc and c-ras oncogene expression in IMR-90 fibroblasts .
6476976	0	hydrocortisone	72,86	citrate_synthase	14,30	hydrocortisone	citrate synthase	MESH:D006854	170587(Tax:10116)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of citrate_synthase and phosphoenolpyruvate_carboxykinase by hydrocortisone in the liver of aging rats .
6692898	0	hydrocortisone	44,58	citrate_synthase	24,40	hydrocortisone	citrate synthase	MESH:D006854	170587(Tax:10116)	Chemical	Gene	response|acl|START_ENTITY response|nmod|END_ENTITY	Age-related response of citrate_synthase to hydrocortisone in the liver and brain of male rats .
6509203	0	hydrocortisone	11,25	cytochrome_P-450	39,55	hydrocortisone	cytochrome P-450	MESH:D006854	100379244(Tax:10141)	Chemical	Gene	system|amod|START_ENTITY system|amod|END_ENTITY	-LSB- Effect of hydrocortisone on the liver cytochrome_P-450 system and the intensity of food_anaphylaxis in guinea_pigs -RSB- .
3106923	0	hydrocortisone	14,28	diamine_oxidase	62,77	hydrocortisone	diamine oxidase	MESH:D006854	65029(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	The effect of hydrocortisone , thyroxine , and phenobarbital on diamine_oxidase activity in newborn rat intestine .
2956052	0	hydrocortisone	33,47	elastin	78,85	hydrocortisone	elastin	MESH:D006854	396441(Tax:9031)	Chemical	Gene	differences|nmod|START_ENTITY differences|nmod|END_ENTITY	Age differences in the effect of hydrocortisone on the synthesis of insoluble elastin in aortic tissue of growing chicks .
6152085	0	hydrocortisone	11,25	gamma-glutamyl_transferase	29,55	hydrocortisone	gamma-glutamyl transferase	MESH:D006854	116568(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	-LSB- Effect of hydrocortisone on gamma-glutamyl_transferase activity of the rat liver and hepatoma -RSB- .
6129190	0	hydrocortisone	10,24	gamma_glutamyltransferase	45,70	hydrocortisone	gamma glutamyltransferase	MESH:D006854	116568(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of hydrocortisone and nicotinamide on gamma_glutamyltransferase in primary cultures of rat hepatocytes .
6414868	0	hydrocortisone	10,24	gastrin	28,35	hydrocortisone	gastrin	MESH:D006854	25320(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|cell cell|compound|END_ENTITY	Effect of hydrocortisone on gastrin cell function in various tissues of suckling rats .
1593907	0	hydrocortisone	24,38	granulocyte-macrophage_colony-stimulating_factor	110,158	hydrocortisone	granulocyte-macrophage colony-stimulating factor	MESH:D006854	12981(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|induction induction|nmod|differentiation differentiation|nmod|cells cells|nmod|END_ENTITY	Selective regulation by hydrocortisone of induction of in vivo differentiation of myeloid leukemic cells with granulocyte-macrophage_colony-stimulating_factor , interleukin_6 and interleukin_1_alpha .
1363409	0	hydrocortisone	17,31	growth_hormone	47,61	hydrocortisone	growth hormone	MESH:D006854	2688	Chemical	Gene	effects|nmod|START_ENTITY Acute|dobj|effects Acute|advcl|circulating circulating|dobj|levels levels|amod|END_ENTITY	Acute effects of hydrocortisone on circulating growth_hormone levels in patients with acromegaly .
21318995	0	hydrocortisone	113,127	growth_hormone	21,35	hydrocortisone	growth hormone	MESH:D006854	2688	Chemical	Gene	replacement|amod|START_ENTITY chronic_thyroiditis|nmod|replacement chronic_thyroiditis|nsubj|response response|acl|END_ENTITY	Improved response of growth_hormone to growth_hormone-releasing hormone and reversible chronic_thyroiditis after hydrocortisone replacement in isolated adrenocorticotropic_hormone_deficiency .
3402107	0	hydrocortisone	10,24	growth_hormone	58,72	hydrocortisone	growth hormone	MESH:D006854	81668(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|amod|END_ENTITY	Effect of hydrocortisone on basal and apomorphine-induced growth_hormone secretion in normal subjects .
6125566	0	hydrocortisone	90,104	growth_hormone	18,32	hydrocortisone	growth hormone	MESH:D006854	81668(Tax:10116)	Chemical	Gene	intoxication|compound|START_ENTITY induced|nmod|intoxication induced|nsubj|Effects Effects|nmod|END_ENTITY	Effects of bovine growth_hormone on the retarded cerebral development induced by neonatal hydrocortisone intoxication .
8013941	0	hydrocortisone	10,24	growth_hormone	32,46	hydrocortisone	growth hormone	MESH:D006854	2688	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|response response|amod|END_ENTITY	Effect of hydrocortisone on the growth_hormone response to growth_hormone-releasing hormone in acromegaly .
8492725	0	hydrocortisone	41,55	growth_hormone	71,85	hydrocortisone	growth hormone	MESH:D006854	2688	Chemical	Gene	effect|nmod|START_ENTITY blocks|dobj|effect blocks|advcl|circulating circulating|dobj|levels levels|amod|END_ENTITY	Arginine blocks the inhibitory effect of hydrocortisone on circulating growth_hormone levels in patients with acromegaly .
11041314	0	hydrocortisone	10,24	growth_hormone_releasing_hormone	54,86	hydrocortisone	growth hormone releasing hormone	MESH:D006854	2691	Chemical	Gene	Effect|nmod|START_ENTITY Effect|acl|END_ENTITY	Effect of hydrocortisone on the pituitary response to growth_hormone_releasing_hormone .
18475434	0	hydrocortisone	10,24	interleukin-6	28,41	hydrocortisone	interleukin-6	MESH:D006854	3569	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|production production|amod|END_ENTITY	Effect of hydrocortisone on interleukin-6 production in human , peripheral blood rnononuclear ceils .
3007577	1	hydrocortisone	112,126	interleukin_2	84,97	hydrocortisone	interleukin 2	MESH:D006854	3558	Chemical	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Inhibition of T cell proliferation and interleukin_2 production by hydrocortisone is reversed by leukotriene B4 .
9328321	0	hydrocortisone	30,44	low-density_lipoprotein_receptor	65,97	hydrocortisone	low-density lipoprotein receptor	MESH:D006854	3949	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|amod|END_ENTITY	Additive inhibitory effect of hydrocortisone and cyclosporine on low-density_lipoprotein_receptor activity in cultured HepG2 cells .
2473427	0	hydrocortisone	10,24	myelin_basic_protein	28,48	hydrocortisone	myelin basic protein	MESH:D006854	17196(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of hydrocortisone on myelin_basic_protein in developing primary brain cultures .
3079651	0	hydrocortisone	15,29	parathyroid_hormone	31,50	hydrocortisone	parathyroid hormone	MESH:D006854	19226(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	The effects of hydrocortisone , parathyroid_hormone and the bisphosphonate , APD , on bone resorption in neonatal mouse calvaria .
7322849	0	hydrocortisone	25,39	parathyroid_hormone	75,94	hydrocortisone	parathyroid hormone	MESH:D006854	24694(Tax:10116)	Chemical	Gene	response|nmod|START_ENTITY response|nmod|END_ENTITY	Phosphaturic response of hydrocortisone in the presence and the absence of parathyroid_hormone .
6500996	0	hydrocortisone	10,24	phenylethanolamine-N-methyltransferase	63,101	hydrocortisone	phenylethanolamine-N-methyltransferase	MESH:D006854	24661(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of hydrocortisone on immunohistochemically demonstrable phenylethanolamine-N-methyltransferase in cultures of embryonic and postnatal superior cervical ganglia .
6679744	0	hydrocortisone	50,64	phosphoenolpyruvate_carboxykinase	13,46	hydrocortisone	phosphoenolpyruvate carboxykinase	MESH:D006854	362282(Tax:10116)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of phosphoenolpyruvate_carboxykinase by hydrocortisone in rat liver and brain as a function of age .
1035198	0	hydrocortisone	25,39	somatomedin	72,83	hydrocortisone	somatomedin	MESH:D006854	418090(Tax:9031)	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nsubj|effect	The inhibitory effect of hydrocortisone on the chicken embryo cartilage somatomedin assay .
6105957	0	hydrocortisone	58,72	tyrosine-aminotransferase	24,49	hydrocortisone	tyrosine-aminotransferase	MESH:D006854	24813(Tax:10116)	Chemical	Gene	mRNA|nmod|START_ENTITY mRNA|amod|END_ENTITY	Regulation of rat-liver tyrosine-aminotransferase mRNA by hydrocortisone and by N6 , O2 ' - dibutyryladenosine_3 ' ,5 ' - phosphate .
1533481	0	hydrocortisone	93,107	vasopressin	7,18	hydrocortisone	vasopressin	MESH:D006854	551	Chemical	Gene	treatments|amod|START_ENTITY hypopituitarism|nmod|treatments END_ENTITY|nmod|hypopituitarism	Plasma vasopressin and atrial natriuretic hormone levels in hypopituitarism with and without hydrocortisone treatments : responses to an acute water load .
6976559	0	hydrocortisone	21,35	vasopressin	39,50	hydrocortisone	vasopressin	MESH:D006854	551	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|response response|compound|END_ENTITY	Protective effect of hydrocortisone on vasopressin response in frog skin .
19252340	0	hydrocotarnine	10,24	cytochrome_P450	28,43	hydrocotarnine	cytochrome P450	MESH:C024594	4051	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of hydrocotarnine on cytochrome_P450 and P-glycoprotein .
21481585	1	hydrogen	114,122	CL3	93,96	hydrogen	CL3	MESH:D006859	23284	Chemical	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	CL3 for fermentative hydrogen production .
10990851	0	hydrogen	168,176	CaF2	68,72	hydrogen	CaF2	MESH:D006859	9337	Chemical	Gene	dynamics|nmod|START_ENTITY dynamics|nmod|END_ENTITY	Coherent dynamics of the localized vibrational modes of hydrogen in CaF2 We report the observation of giant quantum coherence effects in the localized modes of ionized hydrogen in synthetic fluorite .
10990851	0	hydrogen	56,64	CaF2	68,72	hydrogen	CaF2	MESH:D006859	9337	Chemical	Gene	dynamics|nmod|START_ENTITY dynamics|nmod|END_ENTITY	Coherent dynamics of the localized vibrational modes of hydrogen in CaF2 We report the observation of giant quantum coherence effects in the localized modes of ionized hydrogen in synthetic fluorite .
24148794	0	hydrogen	68,76	Heme_oxygenase-1	0,16	hydrogen	Heme oxygenase-1	MESH:D006859	3162	Chemical	Gene	effect|nmod|START_ENTITY mediates|dobj|effect mediates|nsubj|END_ENTITY	Heme_oxygenase-1 mediates the anti-inflammatory effect of molecular hydrogen in LPS-stimulated RAW 264.7 macrophages .
26878108	0	hydrogen	11,19	MS2	42,45	hydrogen	MS2	MESH:D006859	100271694	Chemical	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Tuning the hydrogen evolution activity of MS2 -LRB- M = Mo or Nb -RRB- monolayers by strain engineering .
22323816	0	hydrogen	49,57	MoS	12,15	hydrogen	MoS	MESH:D006859	4342	Chemical	Gene	generation|compound|START_ENTITY mimic|nmod|generation mimic|nsubj|site site|compound|END_ENTITY	A molecular MoS edge site mimic for catalytic hydrogen generation .
23060076	0	hydrogen	34,42	MoS	57,60	hydrogen	MoS	MESH:D006859	4342	Chemical	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Highly efficient electrocatalytic hydrogen production by MoS -LRB- x -RRB- grown on graphene-protected 3D Ni foams .
23334494	0	hydrogen	153,161	MoS	37,40	hydrogen	MoS	MESH:D006859	4342	Chemical	Gene	generation|compound|START_ENTITY photocatalyst|nmod|generation construct|dobj|photocatalyst surfaces|xcomp|construct surfaces|nmod|deposition deposition|nmod|____ ____|compound|END_ENTITY	In situ photo-assisted deposition of MoS ____ electrocatalyst_onto_zinc_cadmium_sulphide nanoparticle surfaces to construct an efficient photocatalyst for hydrogen generation .
24251828	0	hydrogen	46,54	MoS	11,14	hydrogen	MoS	MESH:D006859	4342	Chemical	Gene	reaction|compound|START_ENTITY catalysts|nmod|reaction nanosheets|nmod|catalysts nanosheets|nsubj|END_ENTITY	Conducting MoS nanosheets as catalysts for hydrogen evolution reaction .
24488883	0	hydrogen	10,18	MoS	74,77	hydrogen	MoS	MESH:D006859	4342	Chemical	Gene	performance|compound|START_ENTITY performance|nmod|END_ENTITY	Ultrahigh hydrogen evolution performance of under-water `` superaerophobic '' MoS nanostructured electrodes .
24499163	0	hydrogen	41,49	MoS	11,14	hydrogen	MoS	MESH:D006859	4342	Chemical	Gene	evolution|compound|START_ENTITY Tuning|nmod|evolution Tuning|dobj|activity activity|compound|END_ENTITY	Tuning the MoS edge-site activity for hydrogen evolution via support interactions .
24961169	0	hydrogen	95,103	MoS	32,35	hydrogen	MoS	MESH:D006859	4342	Chemical	Gene	evolution|compound|START_ENTITY nanohybrids|nmod|evolution Construction|dep|nanohybrids Construction|nmod|END_ENTITY	Construction of two-dimensional MoS / CdS_p-n nanohybrids for highly efficient photocatalytic hydrogen evolution .
25089653	0	hydrogen	89,97	MoS	27,30	hydrogen	MoS	MESH:D006859	4342	Chemical	Gene	evolution|compound|START_ENTITY supported|nmod|evolution supported|dobj|nanosheets nanosheets|compound|END_ENTITY	Amorphous carbon supported MoS nanosheets as effective catalysts for electrocatalytic hydrogen evolution .
25089760	0	hydrogen	107,115	MoS	25,28	hydrogen	MoS	MESH:D006859	4342	Chemical	Gene	reaction|compound|START_ENTITY heterostructures|nmod|reaction heterostructures|nsubj|Synthesis Synthesis|nmod|nanotube nanotube|compound|END_ENTITY	Synthesis of few-layered MoS nanosheet-coated electrospun SnO nanotube heterostructures for enhanced hydrogen evolution reaction .
26488087	0	hydrogen	10,18	NLRP3	57,62	hydrogen	NLRP3	MESH:D006859	216799(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|compound|END_ENTITY	Molecular hydrogen inhibits lipopolysaccharide-triggered NLRP3 inflammasome activation in macrophages by targeting the mitochondrial reactive oxygen species .
23954468	0	hydrogen	79,87	Nrf2	102,106	hydrogen	Nrf2	MESH:D006859	83619(Tax:10116)	Chemical	Gene	inducing|dobj|START_ENTITY inducing|advcl|activating activating|dobj|expression expression|amod|END_ENTITY	Lactulose ameliorates cerebral_ischemia-reperfusion injury in rats by inducing hydrogen by activating Nrf2 expression .
24912641	0	hydrogen	25,33	Nrf2	13,17	hydrogen	Nrf2	MESH:D006859	18024(Tax:10090)	Chemical	Gene	treatment|compound|START_ENTITY END_ENTITY|nmod|treatment	-LSB- The role of Nrf2 in the hydrogen treatment for intestinal_injury caused by severe sepsis -RSB- .
25230863	0	hydrogen	43,51	Nrf2	9,13	hydrogen	Nrf2	MESH:D006859	18024(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nmod|effects	-LSB- Role of Nrf2 in the protective effects of hydrogen against cerebral_dysfunction in septic mice -RSB- .
26276082	0	hydrogen	10,18	Nrf2	104,108	hydrogen	Nrf2	MESH:D006859	4780	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|advcl|activating activating|dobj|expression expression|amod|END_ENTITY	Molecular hydrogen attenuates hypoxia/reoxygenation injury of intrahepatic cholangiocytes by activating Nrf2 expression .
25089760	0	hydrogen	107,115	SnO	61,64	hydrogen	SnO	MESH:D006859	55206	Chemical	Gene	reaction|compound|START_ENTITY heterostructures|nmod|reaction heterostructures|nsubj|Synthesis Synthesis|nmod|nanotube nanotube|compound|END_ENTITY	Synthesis of few-layered MoS nanosheet-coated electrospun SnO nanotube heterostructures for enhanced hydrogen evolution reaction .
23473504	0	hydrogen	36,44	cyclooxygenase-1	69,85	hydrogen	cyclooxygenase-1	MESH:D006859	5742	Chemical	Gene	reaction|compound|START_ENTITY reaction|nmod|END_ENTITY	Conformational effects on the pro-S hydrogen abstraction reaction in cyclooxygenase-1 : an integrated QM/MM and MD study .
6745032	0	hydrogen	33,41	gastrin	22,29	hydrogen	gastrin	MESH:D006859	2520	Chemical	Gene	secretion|compound|START_ENTITY END_ENTITY|nmod|secretion	Comparative effect of gastrin on hydrogen ion secretion , antroduodenal motility and the interdigestive motility complex -LRB- IDMC -RRB- in man .
21880708	0	hydrogen	49,57	insulin	71,78	hydrogen	insulin	MESH:D006859	3630	Chemical	Gene	bonds|compound|START_ENTITY bonds|nmod|dimer dimer|compound|END_ENTITY	Non-equivalent role of inter - and intramolecular hydrogen bonds in the insulin dimer interface .
4387276	0	hydrogen	72,80	insulin	10,17	hydrogen	insulin	MESH:D006859	3630	Chemical	Gene	Action|nmod|START_ENTITY Action|nmod|END_ENTITY	Action of insulin and triiodothyronine on energy-controlled pathways of hydrogen .
11942823	0	hydrogen	77,85	lipoxygenase-1	49,63	hydrogen	lipoxygenase-1	MESH:D006859	547923(Tax:3847)	Chemical	Gene	effects|dep|START_ENTITY effects|nmod|END_ENTITY	Temperature-dependent isotope effects in soybean lipoxygenase-1 : correlating hydrogen tunneling with protein dynamics .
7999755	0	hydrogen	57,65	myoglobin	137,146	hydrogen	myoglobin	MESH:D006859	4151	Chemical	Gene	effect|compound|START_ENTITY effect|nmod|END_ENTITY	Spectroscopic study of Ser92 mutants of human myoglobin : hydrogen bonding effect of Ser92 to proximal His93 on structure and property of myoglobin .
18192347	0	hydrogen	34,42	ribonuclease_A	65,79	hydrogen	ribonuclease A	MESH:D006859	6035	Chemical	Gene	mechanism|compound|START_ENTITY mechanism|nmod|END_ENTITY	Destabilizing mutations alter the hydrogen exchange mechanism in ribonuclease_A .
939224	0	hydrogen_carbonate	32,50	pyruvate_carboxylase	76,96	hydrogen carbonate	pyruvate carboxylase	MESH:D001639	5091	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Apparent co-operative effect of hydrogen_carbonate -LRB- HCO-3 -RRB- on pigeon kidney pyruvate_carboxylase .
1261489	0	hydrogen_maleate	40,56	prolactin	66,75	hydrogen maleate	prolactin	MESH:C030272	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|concentrations concentrations|compound|END_ENTITY	Effect of the ergot derivative lisuride hydrogen_maleate on serum prolactin concentrations in female rats .
7308272	0	hydrogen_maleate	101,117	prolactin	136,145	hydrogen maleate	prolactin	MESH:C030272	5617	Chemical	Gene	administration|nmod|START_ENTITY man|nmod|administration lisuride|nmod|man Radioimmunoassay|nmod|lisuride Radioimmunoassay|dep|effect effect|nmod|level level|compound|END_ENTITY	Radioimmunoassay of plasma lisuride in man following intravenous and oral administration of lisuride hydrogen_maleate : effect on plasma prolactin level .
4317722	0	hydrogen_peroside	53,70	lactoperoxidase	90,105	hydrogen peroside	lactoperoxidase	null	4025	Chemical	Gene	oxidation|nmod|START_ENTITY oxidation|nmod|END_ENTITY	The oxidation of reduced nicotinamide_nucleotides by hydrogen_peroside in the presence of lactoperoxidase and thiocyanate , iodide or bromide .
15930012	0	hydrogen_peroxide	48,65	AtGLB1	0,6	hydrogen peroxide	AtGLB1	MESH:D006861	828213(Tax:3702)	Chemical	Gene	enhances|xcomp|START_ENTITY enhances|nsubj|END_ENTITY	AtGLB1 enhances the tolerance of Arabidopsis to hydrogen_peroxide stress .
12097763	0	hydrogen_peroxide	23,40	COPD	51,55	hydrogen peroxide	COPD	MESH:D006861	260431	Chemical	Gene	START_ENTITY|nmod|patients patients|amod|END_ENTITY	Variability of exhaled hydrogen_peroxide in stable COPD patients and matched healthy controls .
21940718	0	hydrogen_peroxide	60,77	Calcium-sensing_receptor	0,24	hydrogen peroxide	Calcium-sensing receptor	MESH:D006861	832370(Tax:3702)	Chemical	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Calcium-sensing_receptor regulates stomatal closure through hydrogen_peroxide and nitric_oxide in response to extracellular calcium in Arabidopsis .
18155705	0	hydrogen_peroxide	57,74	Caspase_3	0,9	hydrogen peroxide	Caspase 3	MESH:D006861	836	Chemical	Gene	activation|acl|START_ENTITY activation|amod|END_ENTITY	Caspase_3 activation in human spermatozoa in response to hydrogen_peroxide and progesterone .
11121887	0	hydrogen_peroxide	132,149	Catalase	0,8	hydrogen peroxide	Catalase	MESH:D006861	24248(Tax:10116)	Chemical	Gene	disposal|nmod|START_ENTITY localization|nmod|disposal END_ENTITY|dep|localization	Catalase in astroglia-rich primary cultures from rat brain : immunocytochemical localization and inactivation during the disposal of hydrogen_peroxide .
12705932	0	hydrogen_peroxide	57,74	Catalase	0,8	hydrogen peroxide	Catalase	MESH:D006861	175086(Tax:6239)	Chemical	Gene	Haemonchus_contortus|nmod|START_ENTITY protects|dobj|Haemonchus_contortus protects|nsubj|induction induction|amod|END_ENTITY	Catalase induction protects Haemonchus_contortus against hydrogen_peroxide in vitro .
14722014	2	hydrogen_peroxide	303,320	Catalase	221,229	hydrogen peroxide	catalase	MESH:D006861	12359(Tax:10090)	Chemical	Gene	level|nmod|START_ENTITY regulating|dobj|level enzyme|acl|regulating enzyme|nsubj|END_ENTITY	Catalase is an important antioxidant enzyme regulating the level of intracellular hydrogen_peroxide and hydroxyl radicals .
15508280	0	hydrogen_peroxide	76,93	Catalase	0,8	hydrogen peroxide	Catalase	MESH:D006861	847	Chemical	Gene	level|amod|START_ENTITY beads|nmod|level acetate|dobj|beads acetate|nsubj|immobilization immobilization|amod|END_ENTITY	Catalase immobilization in cellulose acetate beads and determination of its hydrogen_peroxide decomposition level by using a catalase biosensor .
2491951	0	hydrogen_peroxide	76,93	Catalase	0,8	hydrogen peroxide	Catalase	MESH:D006861	847	Chemical	Gene	detoxification|nmod|START_ENTITY active|nmod|detoxification active|nsubj|peroxidase peroxidase|amod|END_ENTITY	Catalase and glutathione peroxidase are equally active in detoxification of hydrogen_peroxide in human erythrocytes .
26381636	0	hydrogen_peroxide	81,98	Catalase	0,8	hydrogen peroxide	Catalase	MESH:D006861	847	Chemical	Gene	START_ENTITY|nsubj|rehabilitation rehabilitation|amod|END_ENTITY	Catalase and sodium_fluoride mediated rehabilitation of enamel bleached with 37 % hydrogen_peroxide .
9553756	0	hydrogen_peroxide	32,49	Catalase	0,8	hydrogen peroxide	Catalase	MESH:D006861	847	Chemical	Gene	toxicity|amod|START_ENTITY decreases|dobj|toxicity decreases|nsubj|transfection transfection|amod|END_ENTITY	Catalase transfection decreases hydrogen_peroxide toxicity in a pancreatic beta cell line .
23539901	0	hydrogen_peroxide	63,80	Cystathionine_gamma-lyase	0,25	hydrogen peroxide	Cystathionine gamma-lyase	MESH:D006861	1491	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	Cystathionine_gamma-lyase expression is regulated by exogenous hydrogen_peroxide in the mammalian cells .
15304367	0	hydrogen_peroxide	18,35	ERK1/2	50,56	hydrogen peroxide	ERK1/2	MESH:D006861	531391;327672	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Role of CaMKII in hydrogen_peroxide activation of ERK1/2 , p38 MAPK , HSP27 and actin reorganization in endothelial cells .
15531748	0	hydrogen_peroxide	107,124	ETA	71,74	hydrogen peroxide	ETA	MESH:D006861	1909	Chemical	Gene	generation|nmod|START_ENTITY generation|compound|END_ENTITY	Endothelin-1 decreases endothelial NOS expression and activity through ETA receptor-mediated generation of hydrogen_peroxide .
21606925	0	hydrogen_peroxide	70,87	Epidermal_growth_factor	0,23	hydrogen peroxide	Epidermal growth factor	MESH:D006861	1950	Chemical	Gene	protects|nmod|START_ENTITY protects|nsubj|END_ENTITY	Epidermal_growth_factor protects the apical junctional complexes from hydrogen_peroxide in bile duct epithelium .
9044254	0	hydrogen_peroxide	77,94	GSH1	64,68	hydrogen peroxide	GSH1	MESH:D006861	853344(Tax:4932)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|gene gene|compound|END_ENTITY	Amino_acid-dependent regulation of the Saccharomyces_cerevisiae GSH1 gene by hydrogen_peroxide .
12059774	0	hydrogen_peroxide	10,27	GroEL	88,93	hydrogen peroxide	GroEL	MESH:D006861	13903475	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|nmod|END_ENTITY	Effect of hydrogen_peroxide on the activity and structure of Escherichia_coli chaperone GroEL .
11053978	3	hydrogen_peroxide	723,740	HB-EGF	629,635	hydrogen peroxide	HB-EGF	MESH:D006861	25433(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|expression expression|amod|END_ENTITY	Hypoxia/reoxygenation increased HB-EGF expression in NRK-52E cells , and at concentrations that induced sublethal cell injury , hydrogen_peroxide -LRB- H -LRB- 2 -RRB- O -LRB- 2 -RRB- -RRB- increased HB-EGF mRNA expression 4.7-fold .
17350594	0	hydrogen_peroxide	48,65	HuR	26,29	hydrogen peroxide	HuR	MESH:D006861	1994	Chemical	Gene	Stabilization|nmod|START_ENTITY Stabilization|nmod|END_ENTITY	Stabilization of Snail by HuR in the process of hydrogen_peroxide induced cell migration .
15611265	0	hydrogen_peroxide	50,67	IL-8	31,35	hydrogen peroxide	IL-8	MESH:D006861	3576	Chemical	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	Inhibition of human neutrophil IL-8 production by hydrogen_peroxide and dysregulation in chronic_granulomatous_disease .
10914492	0	hydrogen_peroxide	28,45	LFA-1	0,5	hydrogen peroxide	LFA-1	MESH:D006861	3683	Chemical	Gene	production|amod|START_ENTITY triggers|dobj|production triggers|nsubj|END_ENTITY	LFA-1 -LRB- CD11a/CD18 -RRB- triggers hydrogen_peroxide production by canine neutrophils .
6686988	0	hydrogen_peroxide	73,90	Lactoperoxidase	0,15	hydrogen peroxide	Lactoperoxidase	MESH:D006861	4025	Chemical	Gene	toxicity|amod|START_ENTITY cultured|nmod|toxicity cultured|nsubj|protect protect|amod|END_ENTITY	Lactoperoxidase and thiocyanate protect cultured mammalian cells against hydrogen_peroxide toxicity .
7033135	0	hydrogen_peroxide	54,71	Lactoperoxidase	0,15	hydrogen peroxide	Lactoperoxidase	MESH:D006861	4025	Chemical	Gene	protect|nmod|START_ENTITY protect|nsubj|END_ENTITY	Lactoperoxidase and thiocyanate protect bacteria from hydrogen_peroxide .
7538674	0	hydrogen_peroxide	49,66	Lck	18,21	hydrogen peroxide	Lck	MESH:D006861	3932	Chemical	Gene	kinase|nmod|START_ENTITY kinase|compound|END_ENTITY	Activation of the Lck tyrosine protein kinase by hydrogen_peroxide requires the phosphorylation of Tyr-394 .
20043988	0	hydrogen_peroxide	41,58	NADPH_oxidase	24,37	hydrogen peroxide	NADPH oxidase	MESH:D006861	1536	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of phagocyte NADPH_oxidase by hydrogen_peroxide through a Ca -LRB- 2 + -RRB- / c-Abl signaling pathway .
25915537	0	hydrogen_peroxide	79,96	NADPH_oxidase_4	111,126	hydrogen peroxide	NADPH oxidase 4	MESH:D006861	50490(Tax:10090)	Chemical	Gene	START_ENTITY|acl|generated generated|nmod|END_ENTITY	Ubiquitin_C-terminal_hydrolase-L1 increases cancer cell invasion by modulating hydrogen_peroxide generated via NADPH_oxidase_4 .
25915537	0	hydrogen_peroxide	79,96	NADPH_oxidase_4	111,126	hydrogen peroxide	NADPH oxidase 4	MESH:D006861	50490(Tax:10090)	Chemical	Gene	START_ENTITY|acl|generated generated|nmod|END_ENTITY	Ubiquitin_C-terminal_hydrolase-L1 increases cancer cell invasion by modulating hydrogen_peroxide generated via NADPH_oxidase_4 .
20497715	0	hydrogen_peroxide	19,36	NF-E2-related_factor_2	72,94	hydrogen peroxide	NF-E2-related factor 2	MESH:D006861	83619(Tax:10116)	Chemical	Gene	regulation|amod|START_ENTITY END_ENTITY|nsubj|regulation	Low - and high-dose hydrogen_peroxide regulation of transcription factor NF-E2-related_factor_2 .
11858955	0	hydrogen_peroxide	48,65	NF-kappaB	23,32	hydrogen peroxide	NF-kappaB	MESH:D006861	4790	Chemical	Gene	activation|nmod|START_ENTITY activation|nsubj|kappaB kappaB|appos|END_ENTITY	Nuclear factor kappaB -LRB- NF-kappaB -RRB- activation by hydrogen_peroxide in human epidermal keratinocytes and the restorative effect of interleukin-10 .
12162897	0	hydrogen_peroxide	80,97	NF-kappaB	14,23	hydrogen peroxide	NF-kappaB	MESH:D006861	4790	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Activation Activation|nmod|END_ENTITY	Activation of NF-kappaB and apoptosis of intestinal epithelial cells induced by hydrogen_peroxide .
12532330	0	hydrogen_peroxide	63,80	NF-kappaB	50,59	hydrogen peroxide	NF-kappaB	MESH:D006861	18033(Tax:10090)	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Raf-independent and MEKK1-dependent activation of NF-kappaB by hydrogen_peroxide in 70Z/3 pre-B lymphocyte tumor cells .
17392377	0	hydrogen_peroxide	12,29	NF-kappaB	41,50	hydrogen peroxide	NF-kappaB	MESH:D006861	18033(Tax:10090)	Chemical	Gene	diminishes|dep|START_ENTITY diminishes|nsubj|activation activation|amod|END_ENTITY	Exposure to hydrogen_peroxide diminishes NF-kappaB activation , IkappaB-alpha degradation , and proteasome activity in neutrophils .
19496701	0	hydrogen_peroxide	8,25	NF-kappaB	29,38	hydrogen peroxide	NF-kappaB	MESH:D006861	4790	Chemical	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Role of hydrogen_peroxide in NF-kappaB activation : from inducer to modulator .
11182527	0	hydrogen_peroxide	58,75	NF-kappa_B	0,10	hydrogen peroxide	NF-kappa B	MESH:D006861	4790	Chemical	Gene	mediates|xcomp|START_ENTITY mediates|nsubj|END_ENTITY	NF-kappa_B mediates the adaptation of human U937 cells to hydrogen_peroxide .
7639530	0	hydrogen_peroxide	46,63	NF-kappa_B	0,10	hydrogen peroxide	NF-kappa B	MESH:D006861	4790	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	NF-kappa_B transcription factor activation by hydrogen_peroxide can be decreased by 2,3-dihydroxybenzoic _ acid and its ethyl_ester derivative .
9383399	0	hydrogen_peroxide	13,30	NF-kappa_B	102,112	hydrogen peroxide	NF-kappa B	MESH:D006861	4790	Chemical	Gene	roles|nmod|START_ENTITY roles|nmod|messengers messengers|nmod|activation activation|nmod|END_ENTITY	The roles of hydrogen_peroxide and superoxide as messengers in the activation of transcription factor NF-kappa_B .
9655528	0	hydrogen_peroxide	91,108	NF-kappa_B	66,76	hydrogen peroxide	NF-kappa B	MESH:D006861	4790	Chemical	Gene	prevents|nmod|START_ENTITY prevents|dobj|activation activation|amod|END_ENTITY	Impairment of the mitochondrial electron chain transport prevents NF-kappa_B activation by hydrogen_peroxide .
22548772	0	hydrogen_peroxide	84,101	NT-3	21,25	hydrogen peroxide	NT-3	MESH:D006861	4908	Chemical	Gene	effects|acl|START_ENTITY effects|nmod|END_ENTITY	Differing effects of NT-3 and GDNF on dissociated enteric ganglion cells exposed to hydrogen_peroxide in vitro .
14567983	0	hydrogen_peroxide	100,117	Nrf2	21,25	hydrogen peroxide	Nrf2	MESH:D006861	4780	Chemical	Gene	involvement|nmod|START_ENTITY END_ENTITY|dep|involvement	Transcription factor Nrf2 activation by inorganic arsenic in cultured keratinocytes : involvement of hydrogen_peroxide .
16054588	0	hydrogen_peroxide	36,53	PC3	57,60	hydrogen peroxide	PC3	MESH:D006861	57332	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Doxorubicin increases intracellular hydrogen_peroxide in PC3 prostate_cancer cells .
17350594	0	hydrogen_peroxide	48,65	Snail	17,22	hydrogen peroxide	Snail	MESH:D006861	6615	Chemical	Gene	Stabilization|nmod|START_ENTITY Stabilization|nmod|END_ENTITY	Stabilization of Snail by HuR in the process of hydrogen_peroxide induced cell migration .
24780252	0	hydrogen_peroxide	30,47	TRPA1	0,5	hydrogen peroxide	TRPA1	MESH:D006861	312896(Tax:10116)	Chemical	Gene	stimulation|nmod|START_ENTITY stimulation|compound|END_ENTITY	TRPA1 receptor stimulation by hydrogen_peroxide is critical to trigger hyperalgesia and inflammation in a model of acute_gout .
23918657	0	hydrogen_peroxide	63,80	Transient_receptor_potential_ankyrin_1	0,38	hydrogen peroxide	Transient receptor potential ankyrin 1	MESH:D006861	8989	Chemical	Gene	stimulation|nmod|START_ENTITY stimulation|amod|END_ENTITY	Transient_receptor_potential_ankyrin_1 receptor stimulation by hydrogen_peroxide is critical to trigger pain during monosodium_urate-induced inflammation in rodents .
3316463	0	hydrogen_peroxide	46,63	Tumor_necrosis_factor-alpha	0,27	hydrogen peroxide	Tumor necrosis factor-alpha	MESH:D006861	21926(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha induces increased hydrogen_peroxide production and Fc_receptor expression , but not increased Ia antigen expression by peritoneal macrophages .
16839607	0	hydrogen_peroxide	105,122	alpha-synuclein	70,85	hydrogen peroxide	alpha-synuclein	MESH:D006861	6622	Chemical	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	Products of Cu -LRB- II -RRB- - catalyzed oxidation of the N-terminal fragments of alpha-synuclein in the presence of hydrogen_peroxide .
11125030	0	hydrogen_peroxide	12,29	angiotensin_II	61,75	hydrogen peroxide	angiotensin II	MESH:D006861	24179(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|response response|nmod|END_ENTITY	The role of hydrogen_peroxide in the contractile response to angiotensin_II .
16038618	0	hydrogen_peroxide	89,106	betaine-homocysteine_S-methyltransferase	45,85	hydrogen peroxide	betaine-homocysteine S-methyltransferase	MESH:D006861	635	Chemical	Gene	inactivation|nmod|START_ENTITY inactivation|nmod|END_ENTITY	Conformation-dependent inactivation of human betaine-homocysteine_S-methyltransferase by hydrogen_peroxide in vitro .
11278982	0	hydrogen_peroxide	38,55	c-Jun_N-terminal_kinase	0,23	hydrogen peroxide	c-Jun N-terminal kinase	MESH:D006861	5599	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	c-Jun_N-terminal_kinase activation by hydrogen_peroxide in endothelial cells involves SRC-dependent epidermal_growth_factor_receptor transactivation .
11313966	0	hydrogen_peroxide	95,112	c-Jun_N-terminal_kinase	23,46	hydrogen peroxide	c-Jun N-terminal kinase	MESH:D006861	5599	Chemical	Gene	phosphatase|nmod|START_ENTITY phosphatase|nsubj|Down-regulation Down-regulation|nmod|END_ENTITY	Down-regulation of the c-Jun_N-terminal_kinase -LRB- JNK -RRB- phosphatase M3/6 and activation of JNK by hydrogen_peroxide and pyrrolidine_dithiocarbamate .
12021531	0	hydrogen_peroxide	71,88	c-Jun_N-terminal_kinase	14,37	hydrogen peroxide	c-Jun N-terminal kinase	MESH:D006861	116554(Tax:10116)	Chemical	Gene	cells|amod|START_ENTITY induced|nmod|cells apoptosis|dep|induced apoptosis|nsubj|Inhibition Inhibition|nmod|ameliorates ameliorates|amod|END_ENTITY	Inhibition of c-Jun_N-terminal_kinase ameliorates apoptosis induced by hydrogen_peroxide in the kidney tubule epithelial cells -LRB- NRK-52E -RRB- .
10814534	0	hydrogen_peroxide	21,38	c-jun	95,100	hydrogen peroxide	c-jun	MESH:D006861	3725	Chemical	Gene	induced|nmod|START_ENTITY induced|nmod|END_ENTITY	Apoptosis induced by hydrogen_peroxide under serum deprivation and its inhibition by antisense c-jun in F-MEL cells .
10209276	0	hydrogen_peroxide	107,124	catalase	95,103	hydrogen peroxide	catalase	MESH:D006861	531682(Tax:9913)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of different types of effectors on the kinetic parameters of suicide inactivation of catalase by hydrogen_peroxide .
11110034	0	hydrogen_peroxide	77,94	catalase	8,16	hydrogen peroxide	catalase	MESH:D006861	847	Chemical	Gene	Role|acl|START_ENTITY Role|nmod|END_ENTITY	Role of catalase in pre - and postjunctional responses of mammalian irides to hydrogen_peroxide .
11185567	0	hydrogen_peroxide	24,41	catalase	118,126	hydrogen peroxide	catalase	MESH:D006861	40048(Tax:7227)	Chemical	Gene	release|compound|START_ENTITY release|acl|expressing expressing|dobj|END_ENTITY	Decreased mitochondrial hydrogen_peroxide release in transgenic Drosophila_melanogaster expressing intramitochondrial catalase .
12185138	0	hydrogen_peroxide	14,31	catalase	88,96	hydrogen peroxide	catalase	MESH:D006861	847	Chemical	Gene	Modulation|nmod|START_ENTITY mediated|nsubj|Modulation mediated|dobj|transfer transfer|amod|END_ENTITY	Modulation of hydrogen_peroxide induced injury_to_corneal_endothelium by virus mediated catalase gene transfer .
12364388	0	hydrogen_peroxide	20,37	catalase	43,51	hydrogen peroxide	catalase	MESH:D006861	100135492(Tax:10141)	Chemical	Gene	Decreasing|dobj|START_ENTITY Decreasing|nmod|END_ENTITY	Decreasing cellular hydrogen_peroxide with catalase mimics the effects of hypoxia on the sensitivity of the L-type Ca2 + channel to beta-adrenergic receptor stimulation in cardiac myocytes .
12437668	0	hydrogen_peroxide	89,106	catalase	68,76	hydrogen peroxide	catalase	MESH:D006861	847	Chemical	Gene	removing|dobj|START_ENTITY shows|advcl|removing shows|dobj|role role|nmod|END_ENTITY	Exposure of erythrocytes to methylene_blue shows the active role of catalase in removing hydrogen_peroxide .
12684088	0	hydrogen_peroxide	93,110	catalase	34,42	hydrogen peroxide	catalase	MESH:D006861	847	Chemical	Gene	protection|nmod|START_ENTITY immunotargeting|dep|protection immunotargeting|nmod|END_ENTITY	PECAM-directed immunotargeting of catalase : specific , rapid and transient protection against hydrogen_peroxide .
12872994	0	hydrogen_peroxide	15,32	catalase	50,58	hydrogen peroxide	catalase	MESH:D006861	847	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of hydrogen_peroxide in repression of catalase in TMV-infected resistant tobacco .
1333767	0	hydrogen_peroxide	95,112	catalase	6,14	hydrogen peroxide	catalase	MESH:D006861	847	Chemical	Gene	inhibitor|nmod|START_ENTITY inactivation|nmod|inhibitor agent|nmod|inactivation END_ENTITY|nmod|agent	Serum catalase as the protective agent against inactivation of alpha 1-proteinase inhibitor by hydrogen_peroxide ; comparison between normal and rheumatoid_sera .
15508280	0	hydrogen_peroxide	76,93	catalase	125,133	hydrogen peroxide	catalase	MESH:D006861	847	Chemical	Gene	level|amod|START_ENTITY beads|nmod|level acetate|dobj|beads acetate|advcl|using using|dobj|biosensor biosensor|amod|END_ENTITY	Catalase immobilization in cellulose acetate beads and determination of its hydrogen_peroxide decomposition level by using a catalase biosensor .
15508281	0	hydrogen_peroxide	119,136	catalase	63,71	hydrogen peroxide	catalase	MESH:D006861	847	Chemical	Gene	decomposition|amod|START_ENTITY determination|nmod|decomposition preparation|nmod|determination preparation|amod|END_ENTITY	Immobilization of catalase by entrapping in alginate beads and catalase biosensor preparation for the determination of hydrogen_peroxide decomposition .
16099064	0	hydrogen_peroxide	44,61	catalase	68,76	hydrogen peroxide	catalase	MESH:D006861	847	Chemical	Gene	detection|nmod|START_ENTITY using|nsubj|detection using|dobj|electrodes electrodes|amod|END_ENTITY	Amperometric biosensor for the detection of hydrogen_peroxide using catalase modified electrodes in polyacrylamide .
16298761	0	hydrogen_peroxide	31,48	catalase	77,85	hydrogen peroxide	catalase	MESH:D006861	531682(Tax:9913)	Chemical	Gene	degradation|amod|START_ENTITY pathways|nmod|degradation END_ENTITY|nsubj|pathways	Non-oxygen-forming pathways of hydrogen_peroxide degradation by bovine liver catalase at low hydrogen_peroxide fluxes .
16298761	0	hydrogen_peroxide	93,110	catalase	77,85	hydrogen peroxide	catalase	MESH:D006861	531682(Tax:9913)	Chemical	Gene	fluxes|compound|START_ENTITY END_ENTITY|nmod|fluxes	Non-oxygen-forming pathways of hydrogen_peroxide degradation by bovine liver catalase at low hydrogen_peroxide fluxes .
1727639	0	hydrogen_peroxide	37,54	catalase	131,139	hydrogen peroxide	catalase	MESH:D006861	100773774	Chemical	Gene	resistance|nmod|START_ENTITY Mechanisms|nmod|resistance Mechanisms|dep|significance significance|nmod|activity activity|amod|END_ENTITY	Mechanisms of cellular resistance to hydrogen_peroxide , hyperoxia , and 4-hydroxy-2-nonenal toxicity : the significance of increased catalase activity in H2O2-resistant fibroblasts .
17305120	0	hydrogen_peroxide	22,39	catalase	57,65	hydrogen peroxide	catalase	MESH:D006861	847	Chemical	Gene	removal|nmod|START_ENTITY removal|nmod|END_ENTITY	Continuous removal of hydrogen_peroxide with immobilised catalase for wastewater reuse .
1761490	0	hydrogen_peroxide	60,77	catalase	12,20	hydrogen peroxide	catalase	MESH:D006861	847	Chemical	Gene	decreases|nmod|START_ENTITY decreases|nsubj|END_ENTITY	Human serum catalase decreases endothelial cell injury from hydrogen_peroxide .
1784460	0	hydrogen_peroxide	88,105	catalase	9,17	hydrogen peroxide	catalase	MESH:D006861	100340891(Tax:9986)	Chemical	Gene	regulation|nmod|START_ENTITY Roles|nmod|regulation Roles|nmod|END_ENTITY	Roles of catalase and the glutathione redox cycle in the regulation of anterior-chamber hydrogen_peroxide .
18139190	0	hydrogen_peroxide	102,119	catalase	39,47	hydrogen peroxide	catalase	MESH:D006861	847	Chemical	Gene	reactions|nmod|START_ENTITY compounds|dep|reactions compounds|nmod|END_ENTITY	The primary and secondary compounds of catalase and methyl_or_ethyl_hydrogen_peroxide ; reactions with hydrogen_peroxide .
18597274	0	hydrogen_peroxide	28,45	catalase	16,24	hydrogen peroxide	catalase	MESH:D006861	531682(Tax:9913)	Chemical	Gene	Deactivation|nmod|START_ENTITY Deactivation|nmod|END_ENTITY	Deactivation of catalase by hydrogen_peroxide .
18967474	0	hydrogen_peroxide	48,65	catalase	67,75	hydrogen peroxide	catalase	MESH:D006861	847	Chemical	Gene	determination|nmod|START_ENTITY biosensor|nmod|determination biosensor|dep|electrode electrode|amod|END_ENTITY	A novel biosensor for specific determination of hydrogen_peroxide : catalase enzyme electrode based on dissolved oxygen probe .
19092850	0	hydrogen_peroxide	68,85	catalase	8,16	hydrogen peroxide	catalase	MESH:D006861	847	Chemical	Gene	Role|dep|START_ENTITY Role|nmod|END_ENTITY	Role of catalase in monocytic differentiation of U937 cells by TPA : hydrogen_peroxide as a second messenger .
19845487	0	hydrogen_peroxide	63,80	catalase	50,58	hydrogen peroxide	catalase	MESH:D006861	847	Chemical	Gene	synthesis|amod|START_ENTITY delivery|nmod|synthesis delivery|appos|END_ENTITY	The effect of intracellular antioxidant delivery -LRB- catalase -RRB- on hydrogen_peroxide and proinflammatory cytokine synthesis : a new therapeutic horizon .
2066646	0	hydrogen_peroxide	28,45	catalase	72,80	hydrogen peroxide	catalase	MESH:D006861	12359(Tax:10090)	Chemical	Gene	defense|nmod|START_ENTITY defense|dep|importance importance|nmod|END_ENTITY	Erythrocyte defense against hydrogen_peroxide : preeminent importance of catalase .
20824427	0	hydrogen_peroxide	58,75	catalase	121,129	hydrogen peroxide	catalase	MESH:D006861	847	Chemical	Gene	presence|nmod|START_ENTITY peracetic_acid|nmod|presence peracetic_acid|xcomp|using using|advcl|END_ENTITY	Selective peracetic_acid determination in the presence of hydrogen_peroxide using a label free enzymatic method based on catalase .
21033698	0	hydrogen_peroxide	57,74	catalase	88,96	hydrogen peroxide	catalase	MESH:D006861	12359(Tax:10090)	Chemical	Gene	removal|nmod|START_ENTITY resistance|nmod|removal Improvement|nmod|resistance END_ENTITY|nsubj|Improvement	Improvement of insulin resistance by removal of systemic hydrogen_peroxide by PEGylated catalase in obese mice .
21276205	0	hydrogen_peroxide	113,130	catalase	145,153	hydrogen peroxide	catalase	MESH:D006861	24248(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY protects|nmod|effects protects|nmod|END_ENTITY	Vascular_endothelial_growth_factor protects post-ganglionic sympathetic neurones from the detrimental effects of hydrogen_peroxide by increasing catalase .
21880554	0	hydrogen_peroxide	66,83	catalase	109,117	hydrogen peroxide	catalase	MESH:D006861	847	Chemical	Gene	determination|nmod|START_ENTITY nanobiosensor|nmod|determination based|nsubj|nanobiosensor based|nmod|biocatalysis biocatalysis|nmod|END_ENTITY	A novel impedimetric nanobiosensor for low level determination of hydrogen_peroxide based on biocatalysis of catalase .
22565543	0	hydrogen_peroxide	12,29	catalase	47,55	hydrogen peroxide	catalase	MESH:D006861	531682(Tax:9913)	Chemical	Gene	decomposition|amod|START_ENTITY decomposition|nmod|END_ENTITY	Kinetics of hydrogen_peroxide decomposition by catalase : hydroxylic solvent effects .
22915822	0	hydrogen_peroxide	69,86	catalase	9,17	hydrogen peroxide	catalase	MESH:D006861	847	Chemical	Gene	protects|nmod|START_ENTITY protects|nsubj|END_ENTITY	Internal catalase protects herpes simplex virus from inactivation by hydrogen_peroxide .
23733920	2	hydrogen_peroxide	301,318	catalase	281,289	hydrogen peroxide	catalase	MESH:D006861	12359(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|detoxifies detoxifies|amod|END_ENTITY	Although catalase detoxifies hydrogen_peroxide , embryonic catalase activity is only about 5 % of maternal levels .
24804555	0	hydrogen_peroxide	113,130	catalase	27,35	hydrogen peroxide	catalase	MESH:D006861	847	Chemical	Gene	induced|nmod|START_ENTITY stress|acl|induced protects|nmod|stress protects|nsubj|END_ENTITY	Layer-by-layer immobilized catalase on electrospun nanofibrous mats protects against oxidative stress induced by hydrogen_peroxide .
25499853	0	hydrogen_peroxide	75,92	catalase	25,33	hydrogen peroxide	catalase	MESH:D006861	847	Chemical	Gene	role|nmod|START_ENTITY exploring|dobj|role tool|acl|exploring END_ENTITY|dep|tool	N-glycosylation-negative catalase : a useful tool for exploring the role of hydrogen_peroxide in the endoplasmic reticulum .
26691137	0	hydrogen_peroxide	2,19	catalase	68,76	hydrogen peroxide	catalase	MESH:D006861	847	Chemical	Gene	valve|amod|START_ENTITY valve|dep|phosphorylation phosphorylation|nmod|END_ENTITY	A hydrogen_peroxide safety valve : The reversible phosphorylation of catalase from the freeze-tolerant North American wood frog , Rana sylvatica .
2790032	0	hydrogen_peroxide	14,31	catalase	56,64	hydrogen peroxide	catalase	MESH:D006861	847	Chemical	Gene	Resistance|nmod|START_ENTITY associated|nsubj|Resistance associated|nmod|stability stability|amod|END_ENTITY	Resistance to hydrogen_peroxide associated with altered catalase mRNA stability in MCF7 breast_cancer cells .
3192184	0	hydrogen_peroxide	21,38	catalase	89,97	hydrogen peroxide	catalase	MESH:D006861	24248(Tax:10116)	Chemical	Gene	hepatocytes|amod|START_ENTITY toxicity|nmod|hepatocytes role|nmod|toxicity role|nmod|cycle cycle|amod|END_ENTITY	In vitro toxicity of hydrogen_peroxide against normal vs. tumor rat hepatocytes : role of catalase and of the glutathione redox cycle .
3720947	0	hydrogen_peroxide	34,51	catalase	8,16	hydrogen peroxide	catalase	MESH:D006861	24248(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of catalase in metabolism of hydrogen_peroxide by the perfused rat heart .
4020882	0	hydrogen_peroxide	15,32	catalase	119,127	hydrogen peroxide	catalase	MESH:D006861	847	Chemical	Gene	radical|amod|START_ENTITY Involvement|nmod|radical Involvement|dep|reduction reduction|nmod|release release|nmod|END_ENTITY	Involvement of hydrogen_peroxide and hydroxyl radical in the ` oxygen paradox ' : reduction of creatine kinase release by catalase , allopurinol or deferoxamine , but not by superoxide dismutase .
7281255	0	hydrogen_peroxide	85,102	catalase	45,53	hydrogen peroxide	catalase	MESH:D006861	847	Chemical	Gene	-RSB-|amod|START_ENTITY decomposition|nmod|-RSB- immobilized|nmod|decomposition immobilized|dobj|END_ENTITY	-LSB- Stability of Penicillium vitale immobilized catalase in continuous decomposition of hydrogen_peroxide -RSB- .
7305340	0	hydrogen_peroxide	14,31	catalase	83,91	hydrogen peroxide	catalase	MESH:D006861	847	Chemical	Gene	START_ENTITY|dep|contributions contributions|nmod|peroxidase peroxidase|amod|END_ENTITY	Metabolism of hydrogen_peroxide in isolated hepatocytes : relative contributions of catalase and glutathione peroxidase in decomposition of endogenously generated H2O2 .
7737353	0	hydrogen_peroxide	123,140	catalase	61,69	hydrogen peroxide	catalase	MESH:D006861	12359(Tax:10090)	Chemical	Gene	involvement|nmod|START_ENTITY Activation|dep|involvement Activation|nmod|gene gene|nmod|cells cells|amod|END_ENTITY	Activation of DNA synthesis and expression of the JE gene by catalase in mouse osteoblastic cells : possible involvement of hydrogen_peroxide in negative growth regulation .
8018928	0	hydrogen_peroxide	42,59	catalase	14,22	hydrogen peroxide	catalase	MESH:D006861	847	Chemical	Gene	disposal|nmod|START_ENTITY Importance|nmod|disposal Importance|nmod|END_ENTITY	Importance of catalase in the disposal of hydrogen_peroxide within human erythrocytes .
8151246	0	hydrogen_peroxide	48,65	catalase	8,16	hydrogen peroxide	catalase	MESH:D006861	847	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of catalase in the elimination of residual hydrogen_peroxide following tooth bleaching .
8608252	0	hydrogen_peroxide	48,65	catalase	20,28	hydrogen peroxide	catalase	MESH:D006861	847	Chemical	Gene	disposal|nmod|START_ENTITY role|nmod|disposal role|nmod|END_ENTITY	Predominant role of catalase in the disposal of hydrogen_peroxide within human erythrocytes .
8695649	0	hydrogen_peroxide	79,96	catalase	55,63	hydrogen peroxide	catalase	MESH:D006861	531682(Tax:9913)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Reversible inhibition and irreversible inactivation of catalase in presence of hydrogen_peroxide .
8762051	0	hydrogen_peroxide	49,66	catalase	94,102	hydrogen peroxide	catalase	MESH:D006861	24248(Tax:10116)	Chemical	Gene	myocytes|nmod|START_ENTITY exposure|nmod|myocytes enhances|nsubj|exposure enhances|dobj|expression expression|nmod|END_ENTITY	Chronic exposure of neonatal cardiac myocytes to hydrogen_peroxide enhances the expression of catalase .
8896899	0	hydrogen_peroxide	36,53	catalase	55,63	hydrogen peroxide	catalase	MESH:D006861	847	Chemical	Gene	determination|nmod|START_ENTITY determination|dep|activity activity|amod|END_ENTITY	Spectrophotometric determination of hydrogen_peroxide : catalase activity and rates of hydrogen_peroxide removal by erythrocytes .
8896899	0	hydrogen_peroxide	86,103	catalase	55,63	hydrogen peroxide	catalase	MESH:D006861	847	Chemical	Gene	removal|amod|START_ENTITY activity|nmod|removal activity|amod|END_ENTITY	Spectrophotometric determination of hydrogen_peroxide : catalase activity and rates of hydrogen_peroxide removal by erythrocytes .
8947468	0	hydrogen_peroxide	51,68	catalase	14,22	hydrogen peroxide	catalase	MESH:D006861	847	Chemical	Gene	response|nmod|START_ENTITY END_ENTITY|nmod|response	Importance of catalase in the adaptive response to hydrogen_peroxide : analysis of acatalasaemic Saccharomyces_cerevisiae .
9025968	0	hydrogen_peroxide	52,69	catalase	17,25	hydrogen peroxide	catalase	MESH:D006861	847	Chemical	Gene	concentrations|compound|START_ENTITY Determination|nmod|concentrations Determination|nmod|activity activity|amod|END_ENTITY	Determination of catalase activity at physiological hydrogen_peroxide concentrations .
9300794	0	hydrogen_peroxide	20,37	catalase	79,87	hydrogen peroxide	catalase	MESH:D006861	12359(Tax:10090)	Chemical	Gene	activities|amod|START_ENTITY Characterization|nmod|activities Characterization|dep|activity activity|amod|END_ENTITY	Characterization of hydrogen_peroxide removal activities in mouse hemolysates : catalase activity and hydrogen_peroxide removal activity by hemoglobin .
9541866	0	hydrogen_peroxide	106,123	catalase	71,79	hydrogen peroxide	catalase	MESH:D006861	531682(Tax:9913)	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|temperature temperature|nmod|kinetics kinetics|nmod|reactions reactions|nmod|END_ENTITY	The effects of temperature and pH on the kinetics of reactions between catalase and its suicide substrate hydrogen_peroxide .
15061650	0	hydrogen_peroxide	50,67	ceruloplasmin	25,38	hydrogen peroxide	ceruloplasmin	MESH:D006861	526230(Tax:9913)	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Oxidative aggregation of ceruloplasmin induced by hydrogen_peroxide is prevented by pyruvate .
908331	0	hydrogen_peroxide	41,58	choriomammotropin	18,35	hydrogen peroxide	choriomammotropin	MESH:D006861	1443	Chemical	Gene	Reaction|nmod|START_ENTITY Reaction|nmod|END_ENTITY	Reaction of human choriomammotropin with hydrogen_peroxide .
21176282	0	hydrogen_peroxide	10,27	citrate_synthase	54,70	hydrogen peroxide	citrate synthase	MESH:D006861	100327271(Tax:9986)	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of hydrogen_peroxide on rabbit urinary bladder citrate_synthase activity in the presence and absence of a grape suspension .
16458114	0	hydrogen_peroxide	119,136	cyclooxygenase-2	65,81	hydrogen peroxide	cyclooxygenase-2	MESH:D006861	5743	Chemical	Gene	induced|nmod|START_ENTITY necrosis|acl|induced necrosis|nmod|upregulation upregulation|amod|END_ENTITY	Bcl-2 switches the type of demise from apoptosis to necrosis via cyclooxygenase-2 upregulation in HeLa cell induced by hydrogen_peroxide .
3382731	0	hydrogen_peroxide	12,29	cytochrome_P-450	33,49	hydrogen peroxide	cytochrome P-450	MESH:D006861	4051	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Effects of hydrogen_peroxide on cytochrome_P-450 inactivation -RSB- .
11983422	0	hydrogen_peroxide	12,29	cytochrome_c	75,87	hydrogen peroxide	cytochrome c	MESH:D006861	54205	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Reaction of hydrogen_peroxide and peroxidase activity in carboxymethylated cytochrome_c : spectroscopic and kinetic studies .
17085975	0	hydrogen_peroxide	42,59	cytochrome_c	26,38	hydrogen peroxide	cytochrome c	MESH:D006861	54205	Chemical	Gene	modification|nmod|START_ENTITY modification|nmod|END_ENTITY	Oxidative modification of cytochrome_c by hydrogen_peroxide .
17244493	0	hydrogen_peroxide	102,119	cytochrome_c	89,101	hydrogen peroxide	cytochrome c	MESH:D006861	54205	Chemical	Gene	system|compound|START_ENTITY system|amod|END_ENTITY	Protective effects of histidine_dipeptides on the modification of neurofilament-L by the cytochrome_c / hydrogen_peroxide system .
15100053	1	hydrogen_peroxide	81,98	cytochrome_c_oxidase	112,132	hydrogen peroxide	cytochrome c oxidase	MESH:D006861	282199(Tax:9913)	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|END_ENTITY	On the nature of the amino_acid radical formed following hydrogen_peroxide treatment of cytochrome_c_oxidase .
11597928	0	hydrogen_peroxide	40,57	endothelial_NO_synthase	13,36	hydrogen peroxide	endothelial NO synthase	MESH:D006861	287024(Tax:9913)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of endothelial_NO_synthase by hydrogen_peroxide via a Ca -LRB- 2 + -RRB- / calmodulin-dependent protein kinase II/janus _ kinase_2-dependent pathway .
10679488	0	hydrogen_peroxide	102,119	endothelial_nitric_oxide_synthase	54,87	hydrogen peroxide	endothelial nitric oxide synthase	MESH:D006861	287024(Tax:9913)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Transcriptional and posttranscriptional regulation of endothelial_nitric_oxide_synthase expression by hydrogen_peroxide .
20184449	0	hydrogen_peroxide	101,118	endothelial_nitric_oxide_synthase	49,82	hydrogen peroxide	endothelial nitric oxide synthase	MESH:D006861	4846	Chemical	Gene	predict|nmod|START_ENTITY predict|dobj|collapse collapse|amod|END_ENTITY	Mass spectroscopy and molecular modeling predict endothelial_nitric_oxide_synthase dimer collapse by hydrogen_peroxide through zinc_tetrathiolate metal-binding site disruption .
11278982	0	hydrogen_peroxide	38,55	epidermal_growth_factor_receptor	100,132	hydrogen peroxide	epidermal growth factor receptor	MESH:D006861	1956	Chemical	Gene	activation|nmod|START_ENTITY involves|nsubj|activation involves|dobj|transactivation transactivation|compound|END_ENTITY	c-Jun_N-terminal_kinase activation by hydrogen_peroxide in endothelial cells involves SRC-dependent epidermal_growth_factor_receptor transactivation .
16970944	0	hydrogen_peroxide	99,116	epidermal_growth_factor_receptor	19,51	hydrogen peroxide	epidermal growth factor receptor	MESH:D006861	1956	Chemical	Gene	requires|dobj|START_ENTITY requires|nsubj|Transactivation Transactivation|nmod|END_ENTITY	Transactivation of epidermal_growth_factor_receptor by insulin-like_growth_factor_1 requires basal hydrogen_peroxide .
25542757	0	hydrogen_peroxide	63,80	epidermal_growth_factor_receptor	27,59	hydrogen peroxide	epidermal growth factor receptor	MESH:D006861	1956	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of epidermal_growth_factor_receptor by hydrogen_peroxide and flagellin in cultured lung alveolar epithelial cells .
25542757	0	hydrogen_peroxide	63,80	epidermal_growth_factor_receptor	27,59	hydrogen peroxide	epidermal growth factor receptor	MESH:D006861	1956	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of epidermal_growth_factor_receptor by hydrogen_peroxide and flagellin in cultured lung alveolar epithelial cells .
26896765	0	hydrogen_peroxide	77,94	epidermal_growth_factor_receptor	30,62	hydrogen peroxide	epidermal growth factor receptor	MESH:D006861	1956	Chemical	Gene	transport|amod|START_ENTITY signaling|nmod|transport Involvement|acl|signaling Involvement|nmod|aquaporin-3 aquaporin-3|nmod|END_ENTITY	Involvement of aquaporin-3 in epidermal_growth_factor_receptor signaling via hydrogen_peroxide transport in cancer cells .
11169463	0	hydrogen_peroxide	40,57	erythropoietin	89,103	hydrogen peroxide	erythropoietin	MESH:D006861	2056	Chemical	Gene	suppression|amod|START_ENTITY mechanism|nmod|suppression Stimulation|nmod|mechanism Stimulation|nmod|expression expression|compound|END_ENTITY	Stimulation of GATA-2 as a mechanism of hydrogen_peroxide suppression in hypoxia-induced erythropoietin gene expression .
7980410	0	hydrogen_peroxide	8,25	erythropoietin	45,59	hydrogen peroxide	erythropoietin	MESH:D006861	2056	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|production production|compound|END_ENTITY	Role of hydrogen_peroxide in hypoxia-induced erythropoietin production .
9865591	0	hydrogen_peroxide	59,76	erythropoietin	80,94	hydrogen peroxide	erythropoietin	MESH:D006861	2056	Chemical	Gene	production|nmod|START_ENTITY modulators|nmod|production Effects|nmod|modulators Effects|nmod|synthesis synthesis|compound|END_ENTITY	Effects of modulators of the production and degradation of hydrogen_peroxide on erythropoietin synthesis .
19352401	0	hydrogen_peroxide	8,25	glutathione_peroxidase-1	44,68	hydrogen peroxide	glutathione peroxidase-1	MESH:D006861	14775(Tax:10090)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of hydrogen_peroxide and the impact of glutathione_peroxidase-1 in regulation of cerebral vascular tone .
8181459	0	hydrogen_peroxide	86,103	glyceraldehyde-3-phosphate_dehydrogenase	39,79	hydrogen peroxide	glyceraldehyde-3-phosphate dehydrogenase	MESH:D006861	2597	Chemical	Gene	treatment|amod|START_ENTITY END_ENTITY|nmod|treatment	S-thiolation of human endothelial cell glyceraldehyde-3-phosphate_dehydrogenase after hydrogen_peroxide treatment .
18685041	0	hydrogen_peroxide	14,31	glycolate_oxidase	78,95	hydrogen peroxide	glycolate oxidase	MESH:D006861	827563(Tax:3702)	Chemical	Gene	Generation|nmod|START_ENTITY END_ENTITY|nsubj|Generation	Generation of hydrogen_peroxide in chloroplasts of Arabidopsis overexpressing glycolate_oxidase as an inducible system to study oxidative stress .
20646444	0	hydrogen_peroxide	11,28	human_leukocyte_antigen-G	32,57	hydrogen peroxide	human leukocyte antigen-G	MESH:D006861	3135	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	-LSB- Effect of hydrogen_peroxide on human_leukocyte_antigen-G expression in placental trophoblasts in pre-eclampsia -RSB- .
17849273	0	hydrogen_peroxide	10,27	interleukin-8	31,44	hydrogen peroxide	interleukin-8	MESH:D006861	3576	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|synthesis synthesis|amod|END_ENTITY	Effect of hydrogen_peroxide on interleukin-8 synthesis and death of Caco-2 cells .
19727356	0	hydrogen_peroxide	48,65	lactoperoxidase	15,30	hydrogen peroxide	lactoperoxidase	MESH:D006861	4025	Chemical	Gene	damage|amod|START_ENTITY scavenging|nmod|damage END_ENTITY|advcl|scavenging	Role of airway lactoperoxidase in scavenging of hydrogen_peroxide damage in asthma .
2545551	0	hydrogen_peroxide	36,53	lactoperoxidase	15,30	hydrogen peroxide	lactoperoxidase	MESH:D006861	4025	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of lactoperoxidase with hydrogen_peroxide .
8972456	0	hydrogen_peroxide	71,88	lipoxygenase	55,67	hydrogen peroxide	lipoxygenase	MESH:D006861	543994(Tax:4081)	Chemical	Gene	Protection|nmod|START_ENTITY Protection|nmod|END_ENTITY	Protection by different agents against inactivation of lipoxygenase by hydrogen_peroxide .
11960981	0	hydrogen_peroxide	89,106	long_transient_receptor_potential_channel_2	33,76	hydrogen peroxide	long transient receptor potential channel 2	MESH:D006861	7226	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of the cation channel long_transient_receptor_potential_channel_2 -LRB- LTRPC2 -RRB- by hydrogen_peroxide .
21968016	0	hydrogen_peroxide	127,144	mTOR	20,24	hydrogen peroxide	mTOR	MESH:D006861	21977(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY factor|acl|induced mediates|dobj|factor mediates|nsubj|activation activation|compound|END_ENTITY	Rapamycin sensitive mTOR activation mediates nerve growth factor -LRB- NGF -RRB- induced cell migration and pro-survival effects against hydrogen_peroxide in retinal_pigment_epithelial cells .
1321072	0	hydrogen_peroxide	65,82	methemoglobin	46,59	hydrogen peroxide	methemoglobin	MESH:D006861	3048	Chemical	Gene	catalyzed|nmod|START_ENTITY catalyzed|nmod|END_ENTITY	Oxidation of 3-hydroxykynurenine catalyzed by methemoglobin with hydrogen_peroxide .
2012597	0	hydrogen_peroxide	11,28	mucin	93,98	hydrogen peroxide	mucin	MESH:D006861	65202(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of hydrogen_peroxide , mild trypsin digestion and partial reduction on rat intestinal mucin and its disulphide-bound 118 kDa glycoprotein .
10998045	0	hydrogen_peroxide	46,63	myeloperoxidase	25,40	hydrogen peroxide	myeloperoxidase	MESH:D006861	4353	Chemical	Gene	ion|compound|START_ENTITY Mechanism|nmod|ion Mechanism|nmod|END_ENTITY	Mechanism of reaction of myeloperoxidase with hydrogen_peroxide and chloride ion .
14637135	0	hydrogen_peroxide	63,80	myeloperoxidase	29,44	hydrogen peroxide	myeloperoxidase	MESH:D006861	4353	Chemical	Gene	compound|nmod|START_ENTITY END_ENTITY|xcomp|compound	Direct conversion of ferrous myeloperoxidase to compound II by hydrogen_peroxide : an anaerobic stopped-flow study .
22940471	0	hydrogen_peroxide	49,66	myeloperoxidase	21,36	hydrogen peroxide	myeloperoxidase	MESH:D006861	337514(Tax:7955)	Chemical	Gene	burst|amod|START_ENTITY dampens|dobj|burst dampens|nsubj|END_ENTITY	Neutrophil-delivered myeloperoxidase dampens the hydrogen_peroxide burst after tissue wounding in zebrafish .
24035742	0	hydrogen_peroxide	41,58	myeloperoxidase	22,37	hydrogen peroxide	myeloperoxidase	MESH:D006861	4353	Chemical	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of human myeloperoxidase by hydrogen_peroxide .
2557013	0	hydrogen_peroxide	68,85	myeloperoxidase	27,42	hydrogen peroxide	myeloperoxidase	MESH:D006861	4353	Chemical	Gene	electrode|amod|START_ENTITY measured|nmod|electrode measured|nsubj|Influence Influence|nmod|superoxide superoxide|nmod|kinetics kinetics|amod|END_ENTITY	Influence of superoxide on myeloperoxidase kinetics measured with a hydrogen_peroxide electrode .
2822673	0	hydrogen_peroxide	39,56	myeloperoxidase	18,33	hydrogen peroxide	myeloperoxidase	MESH:D006861	4353	Chemical	Gene	Reaction|nmod|START_ENTITY Reaction|nmod|END_ENTITY	Reaction of human myeloperoxidase with hydrogen_peroxide and its true catalase activity .
2981925	1	hydrogen_peroxide	137,154	myeloperoxidase	120,135	hydrogen peroxide	myeloperoxidase	MESH:D006861	4353	Chemical	Gene	START_ENTITY|nsubj|Characterization Characterization|nmod|model model|nmod|END_ENTITY	I. Characterization of a liposome model and injury by myeloperoxidase , hydrogen_peroxide , and halides .
2989289	1	hydrogen_peroxide	156,173	myeloperoxidase	137,152	hydrogen peroxide	myeloperoxidase	MESH:D006861	4353	Chemical	Gene	utilizing|nmod|START_ENTITY utilizing|dobj|inactivation inactivation|nmod|END_ENTITY	Studies utilizing the inactivation of myeloperoxidase by hydrogen_peroxide and azide .
8718890	0	hydrogen_peroxide	173,190	myeloperoxidase	117,132	hydrogen peroxide	myeloperoxidase	MESH:D006861	4353	Chemical	Gene	complex|nmod|START_ENTITY model|nmod|complex 2.3|dep|model 2.3|acl:relcl|salicylhydroxamic_acid salicylhydroxamic_acid|xcomp|bound bound|nmod|END_ENTITY	2.3 A resolution X-ray crystal structure of the bisubstrate analogue inhibitor salicylhydroxamic_acid bound to human myeloperoxidase : a model for a prereaction complex with hydrogen_peroxide .
9128147	0	hydrogen_peroxide	234,251	myeloperoxidase	59,74	hydrogen peroxide	myeloperoxidase	MESH:D006861	4353	Chemical	Gene	utilizes|xcomp|START_ENTITY utilizes|nsubj|absorption absorption|nmod|END_ENTITY	X-ray absorption and resonance raman spectroscopy of human myeloperoxidase at neutral and acid pH. Myeloperoxidase -LRB- MPO -RRB- , an important enzyme in the oxygen-dependent host defense system of human polymorphonuclear leukocytes , utilizes hydrogen_peroxide to catalyze the production of hypochlorous_acid , an oxidizing bactericidal agent .
11368929	0	hydrogen_peroxide	38,55	myoglobin	95,104	hydrogen peroxide	myoglobin	MESH:D006861	4151	Chemical	Gene	consumption|compound|START_ENTITY consumption|nmod|END_ENTITY	The effects of pH on the mechanism of hydrogen_peroxide and lipid hydroperoxide consumption by myoglobin : a role for the protonated ferryl species .
14559426	0	hydrogen_peroxide	57,74	nitric_oxide_synthase	15,36	hydrogen peroxide	nitric oxide synthase	MESH:D006861	4843	Chemical	Gene	tolerance|compound|START_ENTITY END_ENTITY|nmod|tolerance	Involvement of nitric_oxide_synthase in sucrose-enhanced hydrogen_peroxide tolerance of Rhodococcus sp .
11572474	0	hydrogen_peroxide	30,47	p38	12,15	hydrogen peroxide	p38	MESH:D006861	1432	Chemical	Gene	kinase|nmod|START_ENTITY kinase|amod|END_ENTITY	The role of p38 MAP kinase in hydrogen_peroxide mediated endothelial solute permeability .
15639224	0	hydrogen_peroxide	37,54	peroxidase	10,20	hydrogen peroxide	peroxidase	MESH:D006861	8271940(Tax:3988)	Chemical	Gene	scavenger|nmod|START_ENTITY END_ENTITY|appos|scavenger	Ascorbate peroxidase , a scavenger of hydrogen_peroxide in glyoxysomal membranes .
15759117	0	hydrogen_peroxide	116,133	peroxidase	75,85	hydrogen peroxide	peroxidase	MESH:D006861	548137(Tax:4513)	Chemical	Gene	production|compound|START_ENTITY production|amod|END_ENTITY	Aluminum-induced cell death of barley-root border cells is correlated with peroxidase - and oxalate_oxidase-mediated hydrogen_peroxide production .
16596409	0	hydrogen_peroxide	103,120	peroxidase	134,144	hydrogen peroxide	peroxidase	MESH:D006861	543313(Tax:4565)	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Spent growth medium of Pantoea_agglomerans primes wheat suspension cells for augmented accumulation of hydrogen_peroxide and enhanced peroxidase activity upon elicitation .
12054646	0	hydrogen_peroxide	40,57	phosphatase_2A	22,36	hydrogen peroxide	phosphatase 2A	MESH:D006861	5524	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of protein phosphatase_2A by hydrogen_peroxide and glutathionylation .
22683469	0	hydrogen_peroxide	66,83	placenta_growth_factor	35,57	hydrogen peroxide	placenta growth factor	MESH:D006861	5228	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|mRNA mRNA|compound|END_ENTITY	Post-transcriptional regulation of placenta_growth_factor mRNA by hydrogen_peroxide .
17517884	0	hydrogen_peroxide	10,27	transferrin	51,62	hydrogen peroxide	transferrin	MESH:D006861	7018	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Sustained hydrogen_peroxide induces iron uptake by transferrin receptor-1 independent of the iron regulatory protein/iron-responsive element network .
21465633	0	hydrogen_peroxide	97,114	transferrin	52,63	hydrogen peroxide	transferrin	MESH:D006861	7018	Chemical	Gene	reaction|amod|START_ENTITY catalysed|dep|reaction luminol|dep|catalysed phenyl_manganese_porphyrin|amod|luminol reduction|nmod|phenyl_manganese_porphyrin chemiluminescent|nmod|reduction chemiluminescent|dobj|analysis analysis|nmod|END_ENTITY	A novel chemiluminescent flow-injection analysis of transferrin by its reduction of the luminol -- hydrogen_peroxide reaction catalysed by meso-tetra - -LRB- 3-methoxyl-4-hydroxyl -RRB- phenyl_manganese_porphyrin .
21226238	0	hydrogen_peroxide	51,68	transglutaminase_2	8,26	hydrogen peroxide	transglutaminase 2	MESH:D006861	7052	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Role Role|nmod|END_ENTITY	Role of transglutaminase_2 in apoptosis induced by hydrogen_peroxide in human chondrocytes .
18364033	0	hydrogen_peroxide	56,73	transient_receptor_potential_ankyrin_1	14,52	hydrogen peroxide	transient receptor potential ankyrin 1	MESH:D006861	277328(Tax:10090)	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of transient_receptor_potential_ankyrin_1 by hydrogen_peroxide .
18569864	0	hydrogen_peroxide	108,125	vasodilator_stimulated_phosphoprotein	26,63	hydrogen peroxide	vasodilator stimulated phosphoprotein	MESH:D006861	7408	Chemical	Gene	concentrations|nmod|START_ENTITY END_ENTITY|nmod|concentrations	The nitration of platelet vasodilator_stimulated_phosphoprotein following exposure to low concentrations of hydrogen_peroxide .
24752097	0	hydrogen_sulfide	21,37	BACE-1	41,47	hydrogen sulfide	BACE-1	MESH:D006862	23621	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	-LSB- Effect of exogenous hydrogen_sulfide on BACE-1 enzyme expression and b-amyloid peptide metabolism in high-glucose primary neuronal culture -RSB- .
25034810	0	hydrogen_sulfide	30,46	BKCa	104,108	hydrogen sulfide	BKCa	MESH:D006862	16531(Tax:10090)	Chemical	Gene	START_ENTITY|dep|Role Role|nmod|END_ENTITY	Cellular mechanism underlying hydrogen_sulfide induced mouse tracheal_smooth_muscle relaxation : Role of BKCa .
16025537	0	hydrogen_sulfide	71,87	CO2	15,18	hydrogen sulfide	CO2	MESH:D006862	717	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of pH , CO2 , and flow pattern on the autotrophic degradation of hydrogen_sulfide in a biotrickling filter .
16304263	0	hydrogen_sulfide	11,27	COPD	45,49	hydrogen sulfide	COPD	MESH:D006862	260431	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	Endogenous hydrogen_sulfide in patients with COPD .
22513461	0	hydrogen_sulfide	60,76	HIF-1	16,21	hydrogen sulfide	HIF-1	MESH:D006862	3091	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nmod|effects	-LSB- Involvement of HIF-1 in the migration-promoting effects of hydrogen_sulfide in vascular endothelial cells under normoxic conditions -RSB- .
20823573	0	hydrogen_sulfide	72,88	Hypoxia-inducible_factor-1a	0,27	hydrogen sulfide	Hypoxia-inducible factor-1a	MESH:D006862	29560(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY involved|nmod|effect involved|nsubjpass|END_ENTITY	Hypoxia-inducible_factor-1a is involved in the pro-angiogenic effect of hydrogen_sulfide under hypoxic stress .
18535161	0	hydrogen_sulfide	22,38	IL-6	42,46	hydrogen sulfide	IL-6	MESH:D006862	24498(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|levels levels|amod|END_ENTITY	Regulatory effects of hydrogen_sulfide on IL-6 , IL-8 and IL-10 levels in the plasma and pulmonary tissue of rats with acute_lung_injury .
24841117	0	hydrogen_sulfide	27,43	MET2	0,4	hydrogen sulfide	MET2	MESH:D006862	855444(Tax:4932)	Chemical	Gene	production|nmod|START_ENTITY affects|dobj|production affects|nsubj|END_ENTITY	MET2 affects production of hydrogen_sulfide during wine fermentation .
19855074	0	hydrogen_sulfide	73,89	NF-kappaB	0,9	hydrogen sulfide	NF-kappaB	MESH:D006862	18033(Tax:10090)	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	NF-kappaB independent activation of a series of proinflammatory genes by hydrogen_sulfide .
20456010	0	hydrogen_sulfide	108,124	Src	15,18	hydrogen sulfide	Src	MESH:D006862	20779(Tax:10090)	Chemical	Gene	kinase|nmod|START_ENTITY kinase|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of Src kinase in T-type calcium channel-dependent neuronal differentiation of NG108-15 cells by hydrogen_sulfide .
23499828	0	hydrogen_sulfide	61,77	Thrombospondin-1	0,16	hydrogen sulfide	Thrombospondin-1	MESH:D006862	21825(Tax:10090)	Chemical	Gene	inhibitor|nmod|START_ENTITY inhibitor|nsubj|END_ENTITY	Thrombospondin-1 is a CD47-dependent endogenous inhibitor of hydrogen_sulfide signaling in T cell activation .
17885553	0	hydrogen_sulfide	31,47	angiotensin-converting_enzyme	57,86	hydrogen sulfide	angiotensin-converting enzyme	MESH:D006862	1636	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	The novel gaseous vasorelaxant hydrogen_sulfide inhibits angiotensin-converting_enzyme activity of endothelial cells .
26034979	0	hydrogen_sulfide	11,27	angiotensin_II_type_1_receptor	47,77	hydrogen sulfide	angiotensin II type 1 receptor	MESH:D006862	81638(Tax:10116)	Chemical	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	Endogenous hydrogen_sulfide is associated with angiotensin_II_type_1_receptor in a rat model of carbon_tetrachloride - induced hepatic_fibrosis .
27081462	0	hydrogen_sulfide	32,48	cystathionine_gamma-lyase	111,136	hydrogen sulfide	cystathionine gamma-lyase	MESH:D006862	24962(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|gene gene|nmod|END_ENTITY	Mucosal acidification increases hydrogen_sulfide release through up-regulating gene and protein expressions of cystathionine_gamma-lyase in the rat gastric mucosa .
25571911	0	hydrogen_sulfide	75,91	endothelin-1	36,48	hydrogen sulfide	endothelin-1	MESH:D006862	1906	Chemical	Gene	inhibition|nmod|START_ENTITY END_ENTITY|nmod|inhibition	High glucose induces the release of endothelin-1 through the inhibition of hydrogen_sulfide production in HUVECs .
19418582	0	hydrogen_sulfide	51,67	farnesoid_X_receptor	20,40	hydrogen sulfide	farnesoid X receptor	MESH:D006862	60351(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	Bile-acid-activated farnesoid_X_receptor regulates hydrogen_sulfide production and hepatic microcirculation .
21666111	0	hydrogen_sulfide	11,27	heme_oxygenase-1	115,131	hydrogen sulfide	heme oxygenase-1	MESH:D006862	15368(Tax:10090)	Chemical	Gene	elicits|nsubj|START_ENTITY elicits|parataxis|role role|nmod|END_ENTITY	Antecedent hydrogen_sulfide elicits an anti-inflammatory phenotype in postischemic murine small intestine : role of heme_oxygenase-1 .
25550470	0	hydrogen_sulfide	25,41	hypoxia-inducible_factor-1a	78,105	hydrogen sulfide	hypoxia-inducible factor-1a	MESH:D006862	29560(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY mediated|nsubjpass|effects mediated|advcl|END_ENTITY	Proresolution effects of hydrogen_sulfide during colitis are mediated through hypoxia-inducible_factor-1a .
25008997	0	hydrogen_sulfide	49,65	miR-1	15,20	hydrogen sulfide	miR-1	MESH:D006862	100314077(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nmod|effect	Involvement of miR-1 in the protective effect of hydrogen_sulfide against cardiomyocyte apoptosis induced by ischemia/reperfusion .
24824874	0	hydrogen_sulfide	16,32	myeloperoxidase	38,53	hydrogen sulfide	myeloperoxidase	MESH:D006862	4353	Chemical	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of hydrogen_sulfide with myeloperoxidase .
22694815	0	hydrogen_sulphide	59,76	AKT1	12,16	hydrogen sulphide	AKT1	CHEBI:16136	11651(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY role|nmod|effect role|nmod|END_ENTITY	The role of AKT1 and autophagy in the protective effect of hydrogen_sulphide against hepatic_ischemia / reperfusion injury in mice .
18380003	0	hydrogen_sulphide	42,59	neuroglobin	25,36	hydrogen sulphide	neuroglobin	CHEBI:16136	58157	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	The interaction of human neuroglobin with hydrogen_sulphide .
24200305	0	hydrogen_sulphide	10,27	osteoprotegerin	49,64	hydrogen sulphide	osteoprotegerin	CHEBI:16136	4982	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effect of hydrogen_sulphide on the expression of osteoprotegerin and receptor_activator_of_NF-kB ligand in human periodontal ligament cells induced by tension-force stimulation .
21950400	0	hydrogen_sulphide	42,59	quinone_reductase	9,26	hydrogen sulphide	quinone reductase	CHEBI:16136	12972(Tax:10090)	Chemical	Gene	contributes|xcomp|START_ENTITY contributes|nsubj|END_ENTITY	Sulphide quinone_reductase contributes to hydrogen_sulphide metabolism in murine peripheral tissues but not in the CNS .
18419599	0	hydrogen_sulphide	28,45	substance_P	49,60	hydrogen sulphide	substance P	CHEBI:16136	21333(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Pro-inflammatory effects of hydrogen_sulphide on substance_P in caerulein-induced acute pancreatitis .
16603467	0	hydroperoxide	90,103	MMP-9	46,51	hydroperoxide	MMP-9	MESH:D006861	100008993(Tax:9986)	Chemical	Gene	induced|nmod|START_ENTITY Activation|acl|induced Activation|nmod|END_ENTITY	Activation of AP-1 and increased synthesis of MMP-9 in the rabbit retina induced by lipid hydroperoxide .
12453624	0	hydroperoxide	63,76	acetyl-L-carnitine	19,37	hydroperoxide	acetyl-L-carnitine	MESH:D006861	94041(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|treatment treatment|amod|END_ENTITY	Effects of chronic acetyl-L-carnitine treatment on brain lipid hydroperoxide level and passive avoidance learning in senescence-accelerated mice .
3149509	0	hydroperoxide	57,70	lipoxygenase	20,32	hydroperoxide	lipoxygenase	MESH:D006861	547836(Tax:3847)	Chemical	Gene	absence|nmod|START_ENTITY END_ENTITY|nmod|absence	Activity of soybean lipoxygenase in the absence of lipid hydroperoxide .
6431500	0	hydroperoxide	23,36	lipoxygenase	58,70	hydroperoxide	lipoxygenase	MESH:D006861	547836(Tax:3847)	Chemical	Gene	formation|amod|START_ENTITY stimulates|dobj|formation stimulates|nmod|END_ENTITY	Iothalamate stimulates hydroperoxide formation by soybean lipoxygenase .
16266270	0	hydroperoxide	52,65	myeloperoxidase	85,100	hydroperoxide	myeloperoxidase	MESH:D006861	4353	Chemical	Gene	Generation|nmod|START_ENTITY Generation|nmod|END_ENTITY	Generation of free radicals during decomposition of hydroperoxide in the presence of myeloperoxidase or activated neutrophils .
11368929	0	hydroperoxide	66,79	myoglobin	95,104	hydroperoxide	myoglobin	MESH:D006861	4151	Chemical	Gene	consumption|compound|START_ENTITY consumption|nmod|END_ENTITY	The effects of pH on the mechanism of hydrogen_peroxide and lipid hydroperoxide consumption by myoglobin : a role for the protonated ferryl species .
17503194	0	hydroperoxide_glutathione	60,85	PHGPx	98,103	hydroperoxide glutathione	PHGPx	null	625249(Tax:10090)	Chemical	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Tissue expression and cellular localization of phospholipid hydroperoxide_glutathione peroxidase -LRB- PHGPx -RRB- mRNA in male mice .
9576856	0	hydroperoxide_glutathione	13,38	glutathione_transferases	68,92	hydroperoxide glutathione	glutathione transferases	null	373156	Chemical	Gene	START_ENTITY|dobj|activity activity|nmod|END_ENTITY	Phospholipid hydroperoxide_glutathione peroxidase activity of human glutathione_transferases .
20826080	0	hydroperoxides	42,56	15-LOX-1	70,78	hydroperoxides	15-LOX-1	CHEBI:35924	246	Chemical	Gene	START_ENTITY|acl|generated generated|nmod|END_ENTITY	Selenoprotein_P protects cells from lipid hydroperoxides generated by 15-LOX-1 .
20826080	0	hydroperoxides	42,56	Selenoprotein_P	0,15	hydroperoxides	Selenoprotein P	CHEBI:35924	6403	Chemical	Gene	protects|nmod|START_ENTITY protects|nsubj|END_ENTITY	Selenoprotein_P protects cells from lipid hydroperoxides generated by 15-LOX-1 .
11890669	0	hydroperoxides	36,50	Thioredoxin_reductase	0,21	hydroperoxides	Thioredoxin reductase	CHEBI:35924	113898(Tax:10116)	Chemical	Gene	reduces|dobj|START_ENTITY reduces|nsubj|END_ENTITY	Thioredoxin_reductase reduces lipid hydroperoxides and spares alpha-tocopherol .
3406035	0	hydroperoxides	76,90	cytochrome_P-450	8,24	hydroperoxides	cytochrome P-450	CHEBI:35924	4051	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of cytochrome_P-450 in hydrocarbon formation from xenobiotic and lipid hydroperoxides .
7487112	0	hydroperoxides	58,72	cytochrome_P450	8,23	hydroperoxides	cytochrome P450	CHEBI:35924	25251(Tax:10116)	Chemical	Gene	metabolism|nmod|START_ENTITY END_ENTITY|nmod|metabolism	Role of cytochrome_P450 in the metabolism and toxicity of hydroperoxides in isolated rat hepatocytes .
1175656	0	hydroperoxides	30,44	cytochrome_b5	13,26	hydroperoxides	cytochrome b5	CHEBI:35924	64001(Tax:10116)	Chemical	Gene	Oxidation|nmod|START_ENTITY Oxidation|nmod|END_ENTITY	Oxidation of cytochrome_b5 by hydroperoxides in rat liver .
11068048	0	hydroperoxides	61,75	myeloperoxidase	85,100	hydroperoxides	myeloperoxidase	CHEBI:35924	4353	Chemical	Gene	reduction|nmod|START_ENTITY reduction|nmod|END_ENTITY	Two-electron reduction and one-electron oxidation of organic hydroperoxides by human myeloperoxidase .
1900204	0	hydroperoxy_fatty_acid	125,147	5-lipoxygenase	68,82	hydroperoxy fatty acid	5-lipoxygenase	CHEBI:64009	25290(Tax:10116)	Chemical	Gene	inactivation|nmod|START_ENTITY inactivation|amod|END_ENTITY	12-Lipoxygenase from rat_basophilic_leukemia cells : separation from 5-lipoxygenase and temperature-dependent inactivation by hydroperoxy_fatty_acid .
22150111	0	hydroperoxyeicosatetraenoic_acids	23,56	apolipoprotein_D	89,105	hydroperoxyeicosatetraenoic acids	apolipoprotein D	null	347	Chemical	Gene	reduction|nmod|START_ENTITY reduction|nmod|END_ENTITY	Selective reduction of hydroperoxyeicosatetraenoic_acids to their hydroxy derivatives by apolipoprotein_D : implications for lipid antioxidant activity and Alzheimer 's _ disease .
21059386	0	hydroquinone	45,57	Nrf2	18,22	hydroquinone	Nrf2	MESH:C031927	4780	Chemical	Gene	cytotoxicity|amod|START_ENTITY role|nmod|cytotoxicity role|nmod|END_ENTITY	Essential role of Nrf2 in protection against hydroquinone - and benzoquinone-induced cytotoxicity .
19493487	0	hydroquinone	11,23	Rad18	67,72	hydroquinone	Rad18	MESH:C031927	56852	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of hydroquinone on expression of ubiquitin-ligating enzyme Rad18 in human L-02 hepatic cells -RSB- .
19548583	0	hydroquinone	11,23	Rad6B	74,79	hydroquinone	Rad6B	MESH:C031927	7320	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of hydroquinone on the expression of ubiquitin-conjugating enzyme Rad6B in human L-02 hepatic cells -RSB- .
18226367	0	hydroquinone	52,64	TTRAP	11,16	hydroquinone	TTRAP	MESH:C031927	51567	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Effect Effect|nmod|expression expression|compound|END_ENTITY	-LSB- Effect of TTRAP expression on apoptosis induced by hydroquinone in HL-60 cells in vitro . -RSB- .
19525446	0	hydroquinone	19,31	chondromodulin-I	45,61	hydroquinone	chondromodulin-I	MESH:C031927	11061	Chemical	Gene	up-regulates|compound|START_ENTITY END_ENTITY|nsubj|up-regulates	Benzene metabolite hydroquinone up-regulates chondromodulin-I and inhibits tube formation in human bone marrow endothelial cells .
10994872	0	hydroquinone	13,25	myeloperoxidase	93,108	hydroquinone	myeloperoxidase	MESH:C031927	4353	Chemical	Gene	Oxidation|acl|START_ENTITY Oxidation|nmod|END_ENTITY	Oxidation of hydroquinone , 2,3-dimethylhydroquinone and 2,3,5-trimethylhydroquinone by human myeloperoxidase .
1314822	0	hydroquinone	13,25	myeloperoxidase	29,44	hydroquinone	myeloperoxidase	MESH:C031927	4353	Chemical	Gene	Oxidation|nmod|START_ENTITY Oxidation|nmod|END_ENTITY	Oxidation of hydroquinone by myeloperoxidase .
20651235	0	hydroquinone	24,36	p38	128,131	hydroquinone	p38	MESH:C031927	5594	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Cigarette smoke-related hydroquinone induces filamentous actin reorganization and heat_shock protein 27 phosphorylation through p38 and extracellular_signal-regulated_kinase 1/2 in retinal pigment epithelium : implications for age-related_macular_degeneration .
11888291	0	hydroquinone	95,107	tNOX	124,128	hydroquinone	tNOX	MESH:C031927	10495	Chemical	Gene	oxidase|amod|START_ENTITY oxidase|appos|END_ENTITY	Molecular cloning and characterization of a tumor-associated , growth-related , and time-keeping hydroquinone -LRB- NADH -RRB- oxidase -LRB- tNOX -RRB- of the HeLa cell surface .
18980249	0	hydroquinone	117,129	tNOX	139,143	hydroquinone	tNOX	MESH:C031927	209224(Tax:10090)	Chemical	Gene	oxidase|amod|START_ENTITY oxidase|appos|END_ENTITY	Cell size increased in tissues from transgenic_mice overexpressing a cell surface growth-related and cancer-specific hydroquinone oxidase , tNOX , with protein disulfide-thiol interchange activity .
11016886	0	hydroxamate	41,52	procollagen_C-proteinase	67,91	hydroxamate	procollagen C-proteinase	CHEBI:24648	5547	Chemical	Gene	START_ENTITY|dobj|inhibitors inhibitors|nmod|END_ENTITY	Design and synthesis of acidic dipeptide hydroxamate inhibitors of procollagen_C-proteinase .
3669019	0	hydroxamic_acid	28,43	5-lipoxygenase	58,72	hydroxamic acid	5-lipoxygenase	MESH:D006877	25290(Tax:10116)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	In vivo characterization of hydroxamic_acid inhibitors of 5-lipoxygenase .
21937229	0	hydroxamic_acid	55,70	matrix_metalloproteinase-13	85,112	hydroxamic acid	matrix metalloproteinase-13	MESH:D006877	4322	Chemical	Gene	START_ENTITY|dobj|inhibitors inhibitors|nmod|END_ENTITY	Potent and selective 2-naphthylsulfonamide substituted hydroxamic_acid inhibitors of matrix_metalloproteinase-13 .
17346959	0	hydroxamic_acids	38,54	HDAC8	68,73	hydroxamic acids	HDAC8	MESH:D006877	55869	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Design and evaluation of ` Linkerless ' hydroxamic_acids as selective HDAC8 inhibitors .
22036991	0	hydroxamic_acids	25,41	histone_deacetylase	45,64	hydroxamic acids	histone deacetylase	MESH:D006877	9734	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Benzothiazole-containing hydroxamic_acids as histone_deacetylase inhibitors and antitumor agents .
23521008	0	hydroxamic_acids	38,54	histone_deacetylase	65,84	hydroxamic acids	histone deacetylase	MESH:D006877	9734	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	New benzothiazole/thiazole-containing hydroxamic_acids as potent histone_deacetylase inhibitors and antitumor agents .
24020585	0	hydroxamic_acids	90,106	histone_deacetylase	110,129	hydroxamic acids	histone deacetylase	MESH:D006877	9734	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Synthesis , bioevaluation and docking study of 5-substitutedphenyl-1 ,3,4 - thiadiazole-based hydroxamic_acids as histone_deacetylase inhibitors and antitumor agents .
24185378	0	hydroxamic_acids	19,35	histone_deacetylase	39,58	hydroxamic acids	histone deacetylase	MESH:D006877	9734	Chemical	Gene	Novel|dobj|START_ENTITY Novel|nmod|inhibitors inhibitors|amod|END_ENTITY	Novel isatin-based hydroxamic_acids as histone_deacetylase inhibitors and antitumor agents .
8161513	0	hydroxide	43,52	methemoglobin	80,93	hydroxide	methemoglobin	MESH:C031356	3048	Chemical	Gene	complexes|amod|START_ENTITY complexes|nmod|END_ENTITY	Spin state and axial ligand bonding in the hydroxide complexes of metmyoglobin , methemoglobin , and horseradish peroxidase at room and low temperatures .
15664813	0	hydroxy	76,83	C-6	93,96	hydroxy	C-6	CHEBI:43176	729	Chemical	Gene	group|amod|START_ENTITY group|nmod|END_ENTITY	Synthesis of modified proanthocyanidins : easy and general introduction of a hydroxy group at C-6 of catechin ; efficient synthesis of elephantorrhizol .
24417152	0	hydroxy-safflor_yellow_A	22,46	angiotensin_II	109,123	hydroxy-safflor yellow A	angiotensin II	MESH:C085278	183	Chemical	Gene	effect|nmod|START_ENTITY induced|nsubj|effect induced|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Protective effect of hydroxy-safflor_yellow_A on human umbilical vein endothelial cell apoptosis induced by angiotensin_II -RSB- .
3662534	0	hydroxy_fatty_acids	55,74	prostaglandin_dehydrogenase	83,110	hydroxy fatty acids	prostaglandin dehydrogenase	CHEBI:24654	3248	Chemical	Gene	Oxidation|nmod|START_ENTITY Oxidation|nmod|END_ENTITY	Oxidation of 15-hydroxyeicosatetraenoic_acid and other hydroxy_fatty_acids by lung prostaglandin_dehydrogenase .
10371197	0	hydroxyacyl-CoA	49,64	ERAB	80,84	hydroxyacyl-CoA	ERAB	CHEBI:62618	3028	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	Binding of amyloid beta-peptide to mitochondrial hydroxyacyl-CoA dehydrogenase -LRB- ERAB -RRB- : regulation of an SDR enzyme activity with implications for apoptosis in Alzheimer 's _ disease .
20627591	0	hydroxyalkylaminomethylchromones	30,62	IL-5	73,77	hydroxyalkylaminomethylchromones	IL-5	null	3567	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Design and synthesis of novel hydroxyalkylaminomethylchromones for their IL-5 inhibitory activity .
1573977	0	hydroxyandrostenedione	37,59	aromatase	14,23	hydroxyandrostenedione	aromatase	null	25147(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Effect of the aromatase inhibitor , 4 hydroxyandrostenedione , on the endotoxin-induced changes in steroid hormones in male rats .
10701096	0	hydroxyanisole	25,39	N-acetyltransferase	99,118	hydroxyanisole	N-acetyltransferase	null	116631(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|amod|END_ENTITY	Effects of the butylated hydroxyanisole -LRB- BHA -RRB- and butylated_hydroxytoluene -LRB- BHT -RRB- on the arylamines N-acetyltransferase activity in rat white blood cells .
2285245	0	hydroxyanisole	10,24	glutathione-S-transferase	35,60	hydroxyanisole	glutathione-S-transferase	null	58962(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|activity activity|amod|END_ENTITY	Butylated hydroxyanisole increases glutathione-S-transferase activity in hepatocyte culture .
17617550	0	hydroxyapatite	57,71	BMP-2	48,53	hydroxyapatite	BMP-2	MESH:D017886	650	Chemical	Gene	dynamics|nmod|START_ENTITY dynamics|nmod|END_ENTITY	Understanding adsorption-desorption dynamics of BMP-2 on hydroxyapatite -LRB- 001 -RRB- surface .
19581707	0	hydroxyapatite	43,57	BMP-2	0,5	hydroxyapatite	BMP-2	MESH:D017886	29373(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY release|compound|END_ENTITY	BMP-2 release and dose-response studies in hydroxyapatite and beta-tricalcium_phosphate .
17719629	0	hydroxyapatite	89,103	Connexin_43	0,11	hydroxyapatite	Connexin 43	MESH:D017886	2697	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Connexin_43 expression of foreign body giant cells after implantation of nanoparticulate hydroxyapatite .
21132351	0	hydroxyapatite	87,101	FGF-1	45,50	hydroxyapatite	FGF-1	MESH:D017886	2246	Chemical	Gene	evaluation|nmod|START_ENTITY evaluation|nmod|END_ENTITY	Immobilization and bioactivity evaluation of FGF-1 and FGF-2 on powdered silicon-doped hydroxyapatite and their scaffolds for bone tissue engineering .
281372	0	hydroxyapatite	93,107	NaF	14,17	hydroxyapatite	NaF	MESH:D017886	3576	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of NaF on the bacterial production of polysaccharide and subsequent adsorption on hydroxyapatite .
18062107	0	hydroxyapatite	67,81	P-15	111,115	hydroxyapatite	P-15	MESH:D017886	1030	Chemical	Gene	peptide|amod|START_ENTITY peptide|appos|END_ENTITY	Clinical evaluation of the combination of anorganic bovine-derived hydroxyapatite matrix/cell-binding peptide -LRB- P-15 -RRB- in particulate and hydrogel form as a bone replacement graft material in human periodontal osseous defects : 6-month reentry controlled clinical study .
19578280	0	hydroxyapatite	44,58	erythropoietin	22,36	hydroxyapatite	erythropoietin	MESH:D017886	13856(Tax:10090)	Chemical	Gene	carrier|amod|START_ENTITY END_ENTITY|nmod|carrier	Sustained efficacy of erythropoietin with a hydroxyapatite carrier administered in mice .
19783129	0	hydroxyapatite	68,82	osteopontin	49,60	hydroxyapatite	osteopontin	MESH:D017886	6696	Chemical	Gene	surfaces|compound|START_ENTITY surfaces|amod|END_ENTITY	Interaction of human mesenchymal stem cells with osteopontin coated hydroxyapatite surfaces .
9415647	0	hydroxyapatite	18,32	tumor_necrosis_factor-alpha	76,103	hydroxyapatite	tumor necrosis factor-alpha	MESH:D017886	21926(Tax:10090)	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|amod|END_ENTITY	Monosodium_urate , hydroxyapatite , and calcium_pyrophosphate crystals induce tumor_necrosis_factor-alpha expression in a mononuclear cell line .
23149928	0	hydroxybupropion	67,83	CYP2B6	0,6	hydroxybupropion	CYP2B6	MESH:C580748	1555	Chemical	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	CYP2B6 and bupropion 's smoking-cessation pharmacology : the role of hydroxybupropion .
23044204	0	hydroxycamptothecin	12,31	TGFb1	35,40	hydroxycamptothecin	TGFb1	null	59086(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	-LSB- Effects of hydroxycamptothecin on TGFb1 , a-SMA and collagen I expression in rat hepatic satellite cells -RSB- .
25966236	0	hydroxycamptothecin	11,30	matrix_metalloproteinase-1	52,78	hydroxycamptothecin	matrix metalloproteinase-1	null	300339(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of hydroxycamptothecin on the expression of matrix_metalloproteinase-1 -LRB- MMP-1 -RRB- , tissue inhibitor of MMP-1 , and type I collagen in rats with pulmonary_fibrosis .
21222511	0	hydroxychalcone	35,50	b-secretase	71,82	hydroxychalcone	b-secretase	null	23621	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Design , synthesis and SAR study of hydroxychalcone inhibitors of human b-secretase -LRB- BACE1 -RRB- .
26082314	0	hydroxychloroquine	56,74	15-Hydroxyprostaglandin_dehydrogenase	0,37	hydroxychloroquine	15-Hydroxyprostaglandin dehydrogenase	MESH:D006886	873	Chemical	Gene	upregulated|nmod|START_ENTITY upregulated|nsubjpass|END_ENTITY	15-Hydroxyprostaglandin_dehydrogenase is upregulated by hydroxychloroquine in rheumatoid_arthritis fibroblast-like synoviocytes .
23940455	0	hydroxychloroquine	20,38	Akt	71,74	hydroxychloroquine	Akt	MESH:D006886	24185(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of low-dose hydroxychloroquine on expression of phosphorylated Akt and p53 proteins and cardiomyocyte apoptosis in peri-infarct myocardium in rats .
24991838	0	hydroxychloroquine	57,75	MTOR	9,13	hydroxychloroquine	MTOR	MESH:D006886	2475	Chemical	Gene	trial|nmod|START_ENTITY END_ENTITY|dep|trial	Combined MTOR and autophagy inhibition : phase I trial of hydroxychloroquine and temsirolimus in patients with advanced solid tumors and melanoma .
6600237	0	hydroxycholecalciferol	50,72	parathyroid_hormone	23,42	hydroxycholecalciferol	parathyroid hormone	MESH:D006887	5741	Chemical	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	Age-related changes in parathyroid_hormone and 25 hydroxycholecalciferol levels .
21345671	0	hydroxyethyl	53,65	combretastatin_A-4	77,95	hydroxyethyl	combretastatin A-4	null	12351(Tax:10090)	Chemical	Gene	analogs|amod|START_ENTITY analogs|nmod|END_ENTITY	Design and synthesis of novel enhanced water soluble hydroxyethyl analogs of combretastatin_A-4 .
3779884	1	hydroxyethyl_ester	212,230	a_beta	205,211	hydroxyethyl ester	a beta	null	351	Chemical	Gene	group|compound|START_ENTITY group|compound|END_ENTITY	A model study for hydrolysis of phosphotriesters in DNA and on the influence of a_beta hydroxyethyl_ester group .
18457381	0	hydroxyethylamine	21,38	BACE-1	39,45	hydroxyethylamine	BACE-1	null	23621	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Second generation of hydroxyethylamine BACE-1 inhibitors : optimizing potency and oral bioavailability .
20822903	0	hydroxyethylamine	24,41	BACE-1	48,54	hydroxyethylamine	BACE-1	null	23621	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Design and synthesis of hydroxyethylamine -LRB- HEA -RRB- BACE-1 inhibitors : structure-activity relationship of the aryl region .
23010268	0	hydroxyethylamine	31,48	BACE-1	55,61	hydroxyethylamine	BACE-1	null	23621	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Design and synthesis of potent hydroxyethylamine -LRB- HEA -RRB- BACE-1 inhibitors carrying prime side 4,5,6,7-tetrahydrobenzazole and 4,5,6,7-tetrahydropyridinoazole templates .
23856050	0	hydroxyethylamine	24,41	BACE-1	48,54	hydroxyethylamine	BACE-1	null	23621	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Design and synthesis of hydroxyethylamine -LRB- HEA -RRB- BACE-1 inhibitors : prime side chromane-containing inhibitors .
12595750	0	hydroxyitraconazole	85,104	interleukin_6	10,23	hydroxyitraconazole	interleukin 6	MESH:C084794	3569	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of interleukin_6 on the hepatic metabolism of itraconazole and its metabolite hydroxyitraconazole using primary human hepatocytes .
23354476	0	hydroxyl	85,93	TFEA	70,74	hydroxyl	TFEA	MESH:D017665	7030	Chemical	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Theoretical study on rate constants for the reactions of CF3CH_2NH_2 -LRB- TFEA -RRB- with the hydroxyl radical at 298 K and atmospheric pressure .
5663954	0	hydroxylamines	72,86	histidine_decarboxylase	13,36	hydroxylamines	histidine decarboxylase	MESH:D006898	3067	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|Mechanism Mechanism|nmod|END_ENTITY	Mechanism of histidine_decarboxylase inhibition by NSD-1055 and related hydroxylamines .
6617879	0	hydroxylapatite	67,82	mitochondrial_tricarboxylate_carrier	27,63	hydroxylapatite	mitochondrial tricarboxylate carrier	MESH:D017886	29743(Tax:10116)	Chemical	Gene	chromatography|amod|START_ENTITY Purification|nmod|chromatography Purification|nmod|END_ENTITY	Purification of the active mitochondrial_tricarboxylate_carrier by hydroxylapatite chromatography .
26848875	0	hydroxylated_polychlorinated_biphenyls	94,132	glucocorticoid_receptor	45,68	hydroxylated polychlorinated biphenyls	glucocorticoid receptor	null	2908	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Molecular docking and 3D-QSAR studies on the glucocorticoid_receptor antagonistic activity of hydroxylated_polychlorinated_biphenyls .
12433810	0	hydroxymethylglutaryl	45,66	CYP2B6	14,20	hydroxymethylglutaryl	CYP2B6	null	1555	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Regulation of CYP2B6 and CYP3A expression by hydroxymethylglutaryl coenzyme A inhibitors in primary cultured human hepatocytes .
8789420	0	hydroxyphenyl-substituted_tetrahydroisoquinoline	49,97	SL-1	99,103	hydroxyphenyl-substituted tetrahydroisoquinoline	SL-1	null	171045(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Mechanical and electrophysiological effects of a hydroxyphenyl-substituted_tetrahydroisoquinoline , SL-1 , on isolated rat cardiac tissues .
1791467	0	hydroxypyridinones	19,37	transferrin	55,66	hydroxypyridinones	transferrin	null	7018	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	The interaction of hydroxypyridinones with human serum transferrin and ovotransferrin .
21497407	0	hydroxysafflor_yellow_A	47,70	heme_oxygenase-1	16,32	hydroxysafflor yellow A	heme oxygenase-1	MESH:C085278	3162	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Upregulation of heme_oxygenase-1 expression by hydroxysafflor_yellow_A conferring protection from anoxia/reoxygenation-induced apoptosis in H9c2 cardiomyocytes .
10349125	0	hydroxysteroid	16,30	3_beta_HSD	46,56	hydroxysteroid	3 beta HSD	CHEBI:35350	3283	Chemical	Gene	START_ENTITY|dobj|dehydrogenase dehydrogenase|appos|END_ENTITY	-LSB- Role of 3 beta hydroxysteroid dehydrogenase -LRB- 3_beta_HSD -RRB- in human adrenal androgen synthesis -RSB- .
16455123	0	hydroxysteroid	73,87	AKR1C1	104,110	hydroxysteroid	AKR1C1	CHEBI:35350	1645	Chemical	Gene	dehydrogenases|amod|START_ENTITY dehydrogenases|appos|END_ENTITY	Molecular docking simulations of steroid substrates into human cytosolic hydroxysteroid dehydrogenases -LRB- AKR1C1 and AKR1C2 -RRB- : insights into positional and stereochemical preferences .
15371299	0	hydroxysteroid	119,133	SULT2A1	103,110	hydroxysteroid	SULT2A1	CHEBI:35350	6822	Chemical	Gene	START_ENTITY|nsubj|Interactions Interactions|nmod|stereoisomers stereoisomers|nmod|END_ENTITY	Interactions of the stereoisomers of alpha-hydroxytamoxifen with human hydroxysteroid sulfotransferase SULT2A1 and rat hydroxysteroid sulfotransferase STa .
15371299	0	hydroxysteroid	71,85	SULT2A1	103,110	hydroxysteroid	SULT2A1	CHEBI:35350	6822	Chemical	Gene	sulfotransferase|amod|START_ENTITY alpha-hydroxytamoxifen|nmod|sulfotransferase END_ENTITY|amod|alpha-hydroxytamoxifen	Interactions of the stereoisomers of alpha-hydroxytamoxifen with human hydroxysteroid sulfotransferase SULT2A1 and rat hydroxysteroid sulfotransferase STa .
17687072	0	hydroxysteroid	50,64	SULT2A1	83,90	hydroxysteroid	SULT2A1	CHEBI:35350	6822	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Positive and negative regulation of human hepatic hydroxysteroid sulfotransferase -LRB- SULT2A1 -RRB- gene transcription by rifampicin : roles of hepatocyte_nuclear_factor_4alpha and pregnane_X_receptor .
21513704	0	hydroxysteroid	64,78	SULT2A1	97,104	hydroxysteroid	SULT2A1	CHEBI:35350	6822	Chemical	Gene	sulfotransferase|amod|START_ENTITY downregulation|nmod|sulfotransferase downregulation|appos|END_ENTITY	Estrogen-related receptor ERRa-mediated downregulation of human hydroxysteroid sulfotransferase -LRB- SULT2A1 -RRB- in Hep G2 cells .
23211525	0	hydroxysteroid	24,38	SULT2A1	57,64	hydroxysteroid	SULT2A1	CHEBI:35350	6822	Chemical	Gene	START_ENTITY|dobj|sulfotransferase sulfotransferase|appos|END_ENTITY	Regulation of the human hydroxysteroid sulfotransferase -LRB- SULT2A1 -RRB- by RORa and RORy and its potential relevance to human liver_diseases .
24038886	0	hydroxysteroid	51,65	SULT2A1	84,91	hydroxysteroid	SULT2A1	CHEBI:35350	6822	Chemical	Gene	sulfotransferase|amod|START_ENTITY sulfotransferase|appos|END_ENTITY	Estrogen-related receptor ERRa regulation of human hydroxysteroid sulfotransferase -LRB- SULT2A1 -RRB- gene expression in human Caco-2 cells .
16984105	0	hydroxysterols	11,25	tumor_necrosis_factor	86,107	hydroxysterols	tumor necrosis factor	null	21926(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|nmod|END_ENTITY	Effects of hydroxysterols and atorvastatin on lipopolysaccharide-induced secretion of tumor_necrosis_factor and interleukin-10 by mouse macrophages .
9061203	0	hydroxythiazole	45,60	5-lipoxygenase	61,75	hydroxythiazole	5-lipoxygenase	null	240	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Conversion of cyclooxygenase inhibitors into hydroxythiazole 5-lipoxygenase inhibitors .
302840	0	hydroxytryptophan	14,31	growth_hormone	44,58	hydroxytryptophan	growth hormone	null	2688	Chemical	Gene	infusion|compound|START_ENTITY infusion|nmod|END_ENTITY	Effect of 1-5 hydroxytryptophan infusion on growth_hormone and prolactin secretion in man .
15772364	0	hydroxyurea	62,73	Activator_protein-1	0,19	hydroxyurea	Activator protein-1	MESH:D006918	16476(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Activator_protein-1 -LRB- AP-1 -RRB- DNA binding activity is induced by hydroxyurea in organogenesis stage mouse embryos .
15868939	0	hydroxyurea	43,54	Bax	15,18	hydroxyurea	Bax	MESH:D006918	12028(Tax:10090)	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of Bax , Bcl-2 and caspase_3 in hydroxyurea - or etoposide-induced apoptosis of mouse interleukin-3-dependent lymphoma cells .
16528719	0	hydroxyurea	11,22	H2AX	115,119	hydroxyurea	H2AX	MESH:D006918	3014	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of hydroxyurea and aphidicolin on phosphorylation of ataxia_telangiectasia_mutated on Ser 1981 and histone H2AX on Ser 139 in relation to cell cycle phase and induction of apoptosis .
17636317	0	hydroxyurea	48,59	H2AX	0,4	hydroxyurea	H2AX	MESH:D006918	3014	Chemical	Gene	replication|amod|START_ENTITY cells|nmod|replication foci|nmod|cells foci|nummod|END_ENTITY	H2AX foci in late S/G2 - and M-phase cells after hydroxyurea - and aphidicolin-induced DNA replication stress in Vicia .
7640302	0	hydroxyurea	39,50	c-jun	14,19	hydroxyurea	c-jun	MESH:D006918	3725	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of c-jun mRNA expression by hydroxyurea in human K562 cells during erythroid differentiation .
14634278	0	hydroxyurea	47,58	c-myc	32,37	hydroxyurea	c-myc	MESH:D006918	4609	Chemical	Gene	genes|nmod|START_ENTITY genes|amod|END_ENTITY	Elimination of extrachromosomal c-myc genes by hydroxyurea induces apoptosis .
9234574	0	hydroxyurea	85,96	granulocyte-macrophage_colony-stimulating_factor	7,55	hydroxyurea	granulocyte-macrophage colony-stimulating factor	MESH:D006918	1437	Chemical	Gene	Use|nmod|START_ENTITY Use|nmod|END_ENTITY	Use of granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- in combination with hydroxyurea as post-transplant therapy in chronic_myelogenous_leukemia patients autografted with unmanipulated hematopoietic cells .
15927844	0	hydroxyurea	24,35	interleukin-13	52,66	hydroxyurea	interleukin-13	MESH:D006918	16163(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|secretion secretion|amod|END_ENTITY	Differential effects of hydroxyurea and zileuton on interleukin-13 secretion by activated murine spleen cells : implication on the expression of vascular_cell_adhesion_molecule-1 and vasoocclusion in sickle_cell_anemia .
8221660	0	hydroxyurea	29,40	ornithine_decarboxylase	178,201	hydroxyurea	ornithine decarboxylase	MESH:D006918	4953	Chemical	Gene	Development|nmod|START_ENTITY Development|nmod|subunit subunit|amod|END_ENTITY	Development of resistance to hydroxyurea during treatment of human myelogenous_leukemia K562 cells with alpha-difluoromethylornithine as a result of coamplification of genes for ornithine_decarboxylase and ribonucleotide reductase R2 subunit .
19558638	0	hydroxyurea	10,21	p53	77,80	hydroxyurea	p53	MESH:D006918	7157	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of hydroxyurea on the promoter occupancy profiles of tumor suppressor p53 and p73 .
20231502	0	hydroxyurea	152,163	p53	86,89	hydroxyurea	p53	MESH:D006918	7157	Chemical	Gene	manifestation|nmod|START_ENTITY eruption|dep|manifestation eruption|acl|demonstrating demonstrating|dobj|expression expression|compound|END_ENTITY	Hydroxyurea-associated dermatomyositis-like eruption demonstrating abnormal epidermal p53 expression : a potential premalignant manifestation of chronic hydroxyurea and UV radiation exposure .
6805512	0	hydroxyurea	38,49	thymidylate_synthase	14,34	hydroxyurea	thymidylate synthase	MESH:D006918	22171(Tax:10090)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of thymidylate_synthase by hydroxyurea in rapidly proliferating P815 mastocytoma cells .
18725508	0	hydroxywarfarin	18,33	UDP_glucuronosyltransferase_1a10	56,88	hydroxywarfarin	UDP glucuronosyltransferase 1a10	null	54575	Chemical	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Identification of hydroxywarfarin binding site in human UDP_glucuronosyltransferase_1a10 : phenylalanine90 is crucial for the glucuronidation of 6 - _ and_7-hydroxywarfarin but not 8-hydroxywarfarin .
9223588	0	hymenialdisine	20,34	interleukin-8	44,57	hymenialdisine	interleukin-8	MESH:C107079	3576	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	The natural product hymenialdisine inhibits interleukin-8 production in U937 cells by inhibition of nuclear factor-kappaB .
20883786	0	hyperforin	15,25	VEGF	39,43	hyperforin	VEGF	MESH:C001654	7422	Chemical	Gene	up-regulates|compound|START_ENTITY END_ENTITY|nsubj|up-regulates	Antidepressant hyperforin up-regulates VEGF in CNS tumour cells .
15303261	0	hyperforin	53,63	interleukin-6	67,80	hyperforin	interleukin-6	MESH:C001654	3569	Chemical	Gene	START_ENTITY|nmod|release release|amod|END_ENTITY	In vitro effects of the dicyclohexylammonium_salt of hyperforin on interleukin-6 release in different experimental models .
23690187	0	hypericin	10,19	ADAMTS-9	27,35	hypericin	ADAMTS-9	MESH:C004965	56999	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of hypericin on the ADAMTS-9 and ADAMTS-8 gene expression in MCF7 breast_cancer cells .
14767550	0	hypericin	94,103	Matrix_metalloproteinase-1	14,40	hypericin	Matrix metalloproteinase-1	MESH:C004965	4312	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|END_ENTITY	Modulation of Matrix_metalloproteinase-1 in nasopharyngeal_cancer cells by photoactivation of hypericin .
17107772	0	hypochlorous_acid	29,46	AIF	123,126	hypochlorous acid	AIF	MESH:D006997	9131	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	The pro-inflammatory oxidant hypochlorous_acid induces Bax-dependent mitochondrial permeabilisation and cell death through AIF - / EndoG-dependent pathways .
22526679	0	hypochlorous_acid	81,98	vascular_peroxidase_1	25,46	hypochlorous acid	vascular peroxidase 1	MESH:D006997	7837	Chemical	Gene	activity|nmod|START_ENTITY activity|nmod|END_ENTITY	Microbicidal activity of vascular_peroxidase_1 in human plasma via generation of hypochlorous_acid .
17708637	0	hypocrellin_A	11,24	vascular_endothelial_growth_factor	42,76	hypocrellin A	vascular endothelial growth factor	MESH:C048388	7422	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of hypocrellin_A on expression of vascular_endothelial_growth_factor and endothelin-1 in human umbilical endothelial cells .
1789243	0	hypoxanthine	88,100	xanthine_oxidoreductase	6,29	hypoxanthine	xanthine oxidoreductase	MESH:D019271	7498	Chemical	Gene	START_ENTITY|nsubj|activity activity|compound|END_ENTITY	Lower xanthine_oxidoreductase activity in isolated perfused hearts if xanthine replaces hypoxanthine as substrate .
9288634	0	hypoxanthine_guanine	22,42	HPRT	70,74	hypoxanthine guanine	HPRT	null	3251	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular analysis of hypoxanthine_guanine phosphoribosyltransferase -LRB- HPRT -RRB- gene in five Korean families with Lesch-Nyhan_syndrome .
19379712	0	hypusine	14,22	eIF5A	73,78	hypusine	eIF5A	CHEBI:21858	1984	Chemical	Gene	modification|amod|START_ENTITY effect|nmod|modification effect|nmod|END_ENTITY	The effect of hypusine modification on the intracellular localization of eIF5A .
9149130	0	hypusine	20,28	eukaryotic_initiation_factor_5A	51,82	hypusine	eukaryotic initiation factor 5A	CHEBI:21858	208691(Tax:10090)	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Marked elevation of hypusine formation activity on eukaryotic_initiation_factor_5A in v-HA-RAS transformed mouse NIH3T3 cells .
21040239	0	ibogaine	56,64	GDNF	68,72	ibogaine	GDNF	MESH:D007050	2668	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Noribogaine , but not 18-MC , exhibits similar actions as ibogaine on GDNF expression and ethanol self-administration .
15659598	0	ibogaine	102,110	Glial_cell_line-derived_neurotrophic_factor	0,43	ibogaine	Glial cell line-derived neurotrophic factor	MESH:D007050	2668	Chemical	Gene	actions|nmod|START_ENTITY mediates|dobj|actions mediates|nsubj|END_ENTITY	Glial_cell_line-derived_neurotrophic_factor mediates the desirable actions of the anti-addiction drug ibogaine against alcohol consumption .
22458604	0	ibogaine	20,28	hERG	38,42	ibogaine	hERG	MESH:D007050	2078	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|channels channels|amod|END_ENTITY	Anti-addiction drug ibogaine inhibits hERG channels : a cardiac_arrhythmia risk .
6667307	0	ibopamine	41,50	prolactin	71,80	ibopamine	prolactin	MESH:C023487	5617	Chemical	Gene	effect|nmod|START_ENTITY evaluation|nmod|effect evaluation|nmod|secretion secretion|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Preliminary evaluation of the effect of ibopamine on the secretion of prolactin -RSB- .
6861440	0	ibopamine	11,20	prolactin	30,39	ibopamine	prolactin	MESH:C023487	5617	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of ibopamine on serum prolactin and growth_hormone levels in hyperprolactinemic and acromegalic subjects .
3551968	0	ibopamine_hydrochloride	17,40	renin	87,92	ibopamine hydrochloride	renin	MESH:C023487	5972	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nsubj|effects	Acute effects of ibopamine_hydrochloride on hemodynamics , plasma catecholamine levels , renin activity , aldosterone , metabolism and blood gas in patients with severe congestive heart_failure .
5170713	0	ibotenic_acid	14,27	snail	66,71	ibotenic acid	snail	MESH:D007051	6615	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of ibotenic_acid and muscimol on single neurons of the snail , Helix aspersa .
25730880	0	ibrutinib	69,78	BTK	101,104	ibrutinib	BTK	MESH:C551803	12229(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Therapeutic antitumor immunity by checkpoint blockade is enhanced by ibrutinib , an inhibitor of both BTK and ITK .
25755291	0	ibrutinib	46,55	BTK	30,33	ibrutinib	BTK	MESH:C551803	695	Chemical	Gene	tyrosine_kinase|amod|START_ENTITY tyrosine_kinase|appos|END_ENTITY	The Bruton 's _ tyrosine_kinase -LRB- BTK -RRB- inhibitor , ibrutinib , with chemoimmunotherapy in patients with chronic_lymphocytic_leukemia .
25972157	0	ibrutinib	62,71	BTK	94,97	ibrutinib	BTK	MESH:C551803	695	Chemical	Gene	resistant|amod|START_ENTITY END_ENTITY|amod|resistant	Hypermorphic mutation of phospholipase_C , _ gamma_2 acquired in ibrutinib resistant CLL confers BTK independency upon BCR activation .
26036311	0	ibrutinib	41,50	Btk	26,29	ibrutinib	Btk	MESH:C551803	695	Chemical	Gene	START_ENTITY|amod|tyrosine_kinase tyrosine_kinase|dep|END_ENTITY	Bruton 's _ tyrosine_kinase -LRB- Btk -RRB- inhibitor ibrutinib suppresses stem-like traits in ovarian_cancer .
18697608	0	ibuprofen	32,41	COX	59,62	ibuprofen	COX	MESH:D007052	1351	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Antiatherosclerotic activity of ibuprofen , a non-selective COX inhibitor -- an animal study .
6525027	0	ibuprofen	56,65	Haptoglobin	0,11	ibuprofen	Haptoglobin	MESH:D007052	3240	Chemical	Gene	therapy|compound|START_ENTITY END_ENTITY|nmod|therapy	Haptoglobin and copper in adjuvant_arthritis during the ibuprofen therapy .
9675622	0	ibuprofen	124,133	MK-0591	83,90	ibuprofen	MK-0591	MESH:D007052	1476692(Tax:190192)	Chemical	Gene	START_ENTITY|nsubj|interaction interaction|nmod|END_ENTITY	Pharmacokinetic and pharmacodynamic interaction between the lipoxygenase inhibitor MK-0591 and the cyclooxygenase inhibitor ibuprofen in man .
2418303	0	ibuprofen	149,158	Myeloperoxidase	0,15	ibuprofen	Myeloperoxidase	MESH:D007052	609986(Tax:9615)	Chemical	Gene	effect|nmod|START_ENTITY activity|dep|effect activity|amod|END_ENTITY	Myeloperoxidase activity as a quantitative marker of polymorphonuclear leukocyte accumulation into an experimental myocardial_infarct -- the effect of ibuprofen on infarct size and polymorphonuclear leukocyte accumulation .
25463020	0	ibuprofen	17,26	cyclooxygenase-2	36,52	ibuprofen	cyclooxygenase-2	MESH:D007052	5743	Chemical	Gene	structure|nmod|START_ENTITY bound|nsubj|structure bound|nmod|END_ENTITY	The structure of ibuprofen bound to cyclooxygenase-2 .
21147219	0	ibuprofen	128,137	hPEPT1	45,51	ibuprofen	hPEPT1	MESH:D007052	6564	Chemical	Gene	prodrugs|compound|START_ENTITY pro-moiety|nmod|prodrugs H-Phe-Ser-OH|nmod|pro-moiety evaluation|nmod|H-Phe-Ser-OH relationships|dep|evaluation relationships|nmod|END_ENTITY	Affinity and translocation relationships via hPEPT1 of H-X aa-Ser-OH_dipeptides : evaluation of H-Phe-Ser-OH as a pro-moiety for ibuprofen and benzoic_acid prodrugs .
2194072	0	ibuprofen	59,68	platelet_activating_factor_receptor	87,122	ibuprofen	platelet activating factor receptor	MESH:D007052	58949(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Endotoxin-induced myocardial_depression in rats : effect of ibuprofen and SDZ_64-688 , a platelet_activating_factor_receptor antagonist .
7505266	0	ibuprofen	10,19	substance_P	64,75	ibuprofen	substance P	MESH:D007052	6863	Chemical	Gene	Effect|nmod|START_ENTITY induced|nsubj|Effect induced|nmod|END_ENTITY	Effect of ibuprofen and diclofenac on the chemotaxis induced by substance_P and transforming growth factor-beta on human monocytes and polymorphonuclear cells .
2538107	0	ibuprofen	71,80	tumor_necrosis_factor	15,36	ibuprofen	tumor necrosis factor	MESH:D007052	7124	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of tumor_necrosis_factor and their selective inhibition by ibuprofen .
24243443	0	ibuprofen_hydrochlorides	64,88	COX-2	92,97	ibuprofen hydrochlorides	COX-2	null	4513	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Synthesis and evaluation of 2 - -LRB- 2-arylmorpholino -RRB- ethyl_esters of ibuprofen_hydrochlorides as COX-2 and serotonin reuptake inhibitors .
22013806	0	icariin	12,19	Bcl-2	23,28	icariin	Bcl-2	MESH:C056599	12043(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expressions expressions|amod|END_ENTITY	-LSB- Effects of icariin on Bcl-2 and Bax protein expressions and eosinophils apoptosis in bronchial asthmatic mice -RSB- .
20019778	0	icariin	11,18	Cbfalpha1	46,55	icariin	Cbfalpha1	MESH:C056599	367218(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expressions expressions|nmod|END_ENTITY	-LSB- Effect of icariin on the mRNA expressions of Cbfalpha1 , BMP2 , BMP4 in rat osteoblasts -RSB- .
26400356	0	icariin	11,18	ER	40,42	icariin	ER	MESH:C056599	2099	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of icariin on the expression of ER , VEGF , and KDR in the endometrial cells of thin endometrium .
25374443	8	icariin	1058,1065	IgG2a	1041,1046	icariin	STAT3	MESH:C056599	20848(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	The alleviated arthritis score and incidence of arthritis and reduced serum levels of IgG2a induced by icariin were abolished with additional IL-17 administration .
18423597	0	icariin	48,55	NF-kappaB	15,24	icariin	NF-kappaB	MESH:C056599	18033(Tax:10090)	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Involvement of NF-kappaB and AP-1 activation in icariin promoted cardiac differentiation of mouse embryonic stem cells .
25270538	0	icariin	11,18	OPG	44,47	icariin	OPG	MESH:C056599	4982	Chemical	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Effects of icariin on the regulation of the OPG - RANKL - RANK system are mediated through the MAPK pathways in IL __ -1 b - stimulated human SW1353 chondrosarcoma cells .
12646997	0	icariin	11,18	PDE5	36,40	icariin	PDE5	MESH:C056599	8654	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities .
25270538	0	icariin	11,18	RANKL	50,55	icariin	RANKL	MESH:C056599	8600	Chemical	Gene	Effects|nmod|START_ENTITY Effects|dep|END_ENTITY	Effects of icariin on the regulation of the OPG - RANKL - RANK system are mediated through the MAPK pathways in IL __ -1 b - stimulated human SW1353 chondrosarcoma cells .
25528476	0	icariin	30,37	Th1	47,50	icariin	Th1	MESH:C056599	57314(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	A natural flavonoid_glucoside icariin inhibits Th1 and Th17 cell differentiation and ameliorates experimental_autoimmune_encephalomyelitis .
23227542	0	icariin	22,29	acetylcholinesterase	33,53	icariin	acetylcholinesterase	MESH:C056599	43	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Inhibitory effect of icariin on acetylcholinesterase -RSB- .
20416296	0	icariin	71,78	androgen_receptor	15,32	icariin	androgen receptor	MESH:C056599	367	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of androgen_receptor in nitric_oxide production induced by icariin in human umbilical vein endothelial cells .
23714056	0	icariin	11,18	receptor_activator_nuclear_factor-kB_ligand_and_osteoprotegerin	40,103	icariin	receptor activator nuclear factor-kB ligand and osteoprotegerin	MESH:C056599	4982	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of icariin on the expression of receptor_activator_nuclear_factor-kB_ligand_and_osteoprotegerin of human periodontal ligament cells -RSB- .
20575385	0	icariin	52,59	snail	65,70	icariin	snail	MESH:C056599	6615	Chemical	Gene	START_ENTITY|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Study on preparation of icaritin by enzymolysis of icariin with snail hydrolase -RSB- .
23586056	0	icotinib	38,46	Cbl-b	17,22	icotinib	Cbl-b	MESH:C531470	868	Chemical	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	Ubiquitin ligase Cbl-b is involved in icotinib -LRB- BPI-2009H -RRB- - induced apoptosis and G1 phase arrest of EGFR mutation-positive non-small-cell lung_cancer .
23514942	0	icotinib	13,21	EGFR	76,80	icotinib	EGFR	MESH:C531470	1956	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|status status|amod|END_ENTITY	-LSB- Efficacy of icotinib for advanced non-small_cell_lung_cancer patients with EGFR status identified -RSB- .
23586056	0	icotinib	38,46	EGFR	100,104	icotinib	EGFR	MESH:C531470	1956	Chemical	Gene	START_ENTITY|dep|apoptosis apoptosis|nmod|lung_cancer lung_cancer|amod|END_ENTITY	Ubiquitin ligase Cbl-b is involved in icotinib -LRB- BPI-2009H -RRB- - induced apoptosis and G1 phase arrest of EGFR mutation-positive non-small-cell lung_cancer .
24777808	0	icotinib	11,19	EGFR	74,78	icotinib	EGFR	MESH:C531470	1956	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|phenotypes phenotypes|compound|END_ENTITY	Effects of icotinib on advanced non-small_cell_lung_cancer with different EGFR phenotypes .
25093093	0	icotinib	24,32	EGFR	106,110	icotinib	EGFR	MESH:C531470	1956	Chemical	Gene	treatment|nmod|START_ENTITY pemetrexed|nsubj|treatment pemetrexed|nmod|status status|compound|END_ENTITY	Sequential treatment of icotinib after first-line pemetrexed in advanced lung_adenocarcinoma with unknown EGFR gene status .
25564053	0	icotinib	31,39	EGFR	84,88	icotinib	EGFR	MESH:C531470	1956	Chemical	Gene	combination|nmod|START_ENTITY Cetuximab|nmod|combination overcomes|nsubj|Cetuximab overcomes|dobj|resistance resistance|acl|caused caused|nmod|mutation mutation|compound|END_ENTITY	-LSB- Cetuximab in combination with icotinib overcomes the acquired resistance caused by EGFR T790M mutation in non-small_cell_lung_cancer -RSB- .
26082644	0	icotinib	15,23	EGFR	140,144	icotinib	EGFR	MESH:C531470	1956	Chemical	Gene	Combination|nmod|START_ENTITY metastasized|nsubj|Combination metastasized|nmod|mutation mutation|amod|END_ENTITY	Combination of icotinib , surgery , and internal-radiotherapy of a patient with lung_cancer severely metastasized to the vertebrae bones with EGFR mutation : a case report .
26622712	0	icotinib	21,29	EGFR	97,101	icotinib	EGFR	MESH:C531470	1956	Chemical	Gene	START_ENTITY|advcl|harboring harboring|dobj|mutation mutation|amod|END_ENTITY	A marked response to icotinib in a patient with large_cell_neuroendocrine_carcinoma harboring an EGFR mutation : A case report .
26629062	0	icotinib	17,25	EGFR	30,34	icotinib	EGFR	MESH:C531470	1956	Chemical	Gene	study|nmod|START_ENTITY Phase|xcomp|study combined|advcl|Phase combined|nsubj|inhibitor inhibitor|compound|END_ENTITY	Phase I study of icotinib , an EGFR tyrosine kinase inhibitor combined with IMRT in nasopharyngeal_carcinoma .
27013591	0	icotinib	66,74	EGFR	20,24	icotinib	EGFR	MESH:C531470	1956	Chemical	Gene	efficacy|amod|START_ENTITY amplification|nmod|efficacy amplification|nsubj|value value|nmod|overexpression overexpression|amod|END_ENTITY	Predictive value of EGFR overexpression and gene amplification on icotinib efficacy in patients with advanced esophageal_squamous_cell_carcinoma .
22088449	0	icotinib	17,25	epidermal_growth_factor_receptor	35,67	icotinib	epidermal growth factor receptor	MESH:C531470	1956	Chemical	Gene	trial|nmod|START_ENTITY Phase|xcomp|trial tyrosine|advcl|Phase tyrosine|nsubj|END_ENTITY	Phase I trial of icotinib , a novel epidermal_growth_factor_receptor tyrosine kinase inhibitor , in Chinese patients with non-small_cell_lung_cancer .
22446631	0	icotinib	11,19	epidermal_growth_factor_receptor	29,61	icotinib	epidermal growth factor receptor	MESH:C531470	1956	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Effects of icotinib , a novel epidermal_growth_factor_receptor tyrosine kinase inhibitor , in EGFR-mutated non-small cell lung_cancer .
26767025	0	icotinib	22,30	epidermal_growth_factor_receptor	94,126	icotinib	epidermal growth factor receptor	MESH:C531470	1956	Chemical	Gene	START_ENTITY|nmod|mutation mutation|nmod|exon exon|nmod|END_ENTITY	Favorable response to icotinib in a lung_cancer patient with a special mutation at exon 19 of epidermal_growth_factor_receptor .
27042123	0	icotinib	11,19	epidermal_growth_factor_receptor	102,134	icotinib	epidermal growth factor receptor	MESH:C531470	1956	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|treatment treatment|nmod|phenotypes phenotypes|compound|END_ENTITY	Effects of icotinib on early-stage non-small-cell_lung_cancer as neoadjuvant treatment with different epidermal_growth_factor_receptor phenotypes .
21144613	0	icotinib_hydrochloride	17,39	EGFR	61,65	icotinib hydrochloride	EGFR	null	1956	Chemical	Gene	study|nmod|START_ENTITY study|appos|inhibitor inhibitor|amod|END_ENTITY	Phase I study of icotinib_hydrochloride -LRB- BPI-2009H -RRB- , an oral EGFR tyrosine kinase inhibitor , in patients with advanced NSCLC and other solid_tumors .
18691757	0	idarubicin	109,119	THP-1	123,128	idarubicin	THP-1	MESH:D015255	2736	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Ligand-induced Flt3-downregulation modulates cell death associated proteins and enhances chemosensitivity to idarubicin in THP-1 acute_myeloid_leukemia cells .
2582171	0	idebenone	11,20	CV-2619	22,29	idebenone	CV-2619	MESH:C036619	2549043(Tax:243365)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of idebenone -LRB- CV-2619 -RRB- on metabolism of monoamines , especially serotonin , in the brain of normal rats and rats with cerebral_ischemia .
4072435	0	idebenone	11,20	CV-2619	22,29	idebenone	CV-2619	MESH:C036619	2549043(Tax:243365)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	-LSB- Effect of idebenone -LRB- CV-2619 -RRB- on brightness discrimination learning in rats with central serotonergic_dysfunction -RSB- .
6500404	0	idebenone	12,21	CV-2619	23,30	idebenone	CV-2619	MESH:C036619	2549043(Tax:243365)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	-LSB- Effects of idebenone -LRB- CV-2619 -RRB- on neurological_deficits , local cerebral blood flow , and energy metabolism in rats with experimental cerebral_ischemia -RSB- .
6521077	0	idebenone	11,20	CV-2619	22,29	idebenone	CV-2619	MESH:C036619	2549043(Tax:243365)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of idebenone -LRB- CV-2619 -RRB- on the concentrations of acetylcholine and choline in various brain regions of rats with cerebral_ischemia .
6542947	0	idebenone	21,30	CV-2619	32,39	idebenone	CV-2619	MESH:C036619	2549043(Tax:243365)	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Beneficial effect of idebenone -LRB- CV-2619 -RRB- on cerebral_ischemia-induced amnesia in rats .
24450858	0	idelalisib	21,31	PI3K	0,4	idelalisib	PI3K	null	5293	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|END_ENTITY	PI3K inhibition by idelalisib in patients with relapsed indolent_lymphoma .
25756507	0	idelalisib	49,59	PI3K	9,13	idelalisib	PI3K	MESH:C552946	5293	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|END_ENTITY	Targeted PI3K inhibition by the small molecule idelalisib as a novel therapy in indolent non-Hodgkin_lymphoma .
10708560	0	idomethacin	73,84	endothelin-converting_enzyme-1	13,43	idomethacin	endothelin-converting enzyme-1	null	1889	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of endothelin-converting_enzyme-1 in gastric_mucosal_injury by idomethacin .
7526067	0	idrapril	68,76	Angiotensin-converting_enzyme	0,29	idrapril	Angiotensin-converting enzyme	MESH:C076966	1636	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Angiotensin-converting_enzyme inhibition by hydroxamic zinc-binding idrapril in humans .
8907795	0	idrapril	58,66	angiotensin-converting_enzyme	17,46	idrapril	angiotensin-converting enzyme	MESH:C076966	24310(Tax:10116)	Chemical	Gene	Effects|dep|START_ENTITY Effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Effects of a new angiotensin-converting_enzyme inhibitor -LRB- idrapril -RRB- in rats with left ventricular_dysfunction after myocardial_infarction .
120987	0	iduronate	85,94	sulfatase	95,104	iduronate	sulfatase	MESH:D007067	347527	Chemical	Gene	deficiency|amod|START_ENTITY deficiency|compound|END_ENTITY	Enrichment of human heterokaryons by Ficoll gradient for complementation analysis of iduronate sulfatase deficiency .
409284	0	iduronate	72,81	sulfatase	82,91	iduronate	sulfatase	MESH:D007067	347527	Chemical	Gene	deficiency|amod|START_ENTITY deficiency|compound|END_ENTITY	The Hunter_syndrome in females : is there an autosomal recessive form of iduronate sulfatase deficiency ?
8490623	0	iduronate_sulphate	65,83	IDS	96,99	iduronate sulphate	IDS	null	3423	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Determination of the organisation of coding sequences within the iduronate_sulphate sulphatase -LRB- IDS -RRB- gene .
24042122	0	ifenprodil	22,32	GluN2B	43,49	ifenprodil	GluN2B	MESH:C010739	24410(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Metabolism studies of ifenprodil , a potent GluN2B receptor antagonist .
10842351	0	ifenprodil	78,88	NR2B	52,56	ifenprodil	NR2B	MESH:C010739	24410(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Enhancement Enhancement|nmod|current current|nmod|antagonist antagonist|compound|END_ENTITY	Enhancement of NMDA-induced current by the putative NR2B selective antagonist ifenprodil .
11123375	0	ifenprodil	138,148	NR2B	199,203	ifenprodil	NR2B	MESH:C010739	24410(Tax:10116)	Chemical	Gene	site|amod|START_ENTITY pharmacology|nmod|site containing|nsubj|pharmacology containing|dobj|subunits subunits|nummod|END_ENTITY	Use of trifluoroperazine isolates a -LSB- -LRB- 3 -RRB- H -RSB- Ifenprodil binding site in rat brain membranes with the pharmacology of the voltage-independent ifenprodil site on N-methyl-D-aspartate receptors containing NR2B subunits .
17849398	0	ifenprodil	77,87	NR2B	21,25	ifenprodil	NR2B	MESH:C010739	2904	Chemical	Gene	receptor|nmod|START_ENTITY domain|nmod|receptor modulatory|dobj|domain modulatory|nsubj|modeling modeling|nmod|END_ENTITY	Homology modeling of NR2B modulatory domain of NMDA receptor and analysis of ifenprodil binding .
20165802	0	ifenprodil	136,146	NR2B	120,124	ifenprodil	NR2B	MESH:C010739	2904	Chemical	Gene	antagonist|xcomp|START_ENTITY antagonist|nsubj|amination amination|nmod|ethanolamine ethanolamine|nmod|synthesis synthesis|nmod|analogues analogues|nmod|END_ENTITY	Copper-catalyzed amination of -LRB- bromophenyl -RRB- ethanolamine for a concise synthesis of aniline-containing analogues of NMDA NR2B antagonist ifenprodil .
20965739	0	ifenprodil	83,93	NR2B	29,33	ifenprodil	NR2B	MESH:C010739	14812(Tax:10090)	Chemical	Gene	derived|nmod|START_ENTITY antagonists|acl|derived END_ENTITY|dep|antagonists	Conformationally constrained NR2B selective NMDA receptor antagonists derived from ifenprodil : Synthesis and biological evaluation of tetrahydro-3-benzazepine-1 ,7 - diols .
21352242	0	ifenprodil	46,56	NR2B	29,33	ifenprodil	NR2B	MESH:C010739	24410(Tax:10116)	Chemical	Gene	Effect|amod|START_ENTITY Effect|nmod|END_ENTITY	Effect of the selective NMDA NR2B antagonist , ifenprodil , on acute tolerance to ethanol-induced motor_impairment in adolescent and adult rats .
22610100	0	ifenprodil	177,187	NR2B	16,20	ifenprodil	NR2B	MESH:C010739	2904	Chemical	Gene	affinities|amod|START_ENTITY site|nmod|affinities identification|nmod|site Cleavage|dep|identification Cleavage|nmod|terminus terminus|nummod|END_ENTITY	Cleavage of the NR2B subunit amino terminus of N-methyl-D-aspartate -LRB- NMDA -RRB- receptor by tissue_plasminogen_activator : identification of the cleavage site and characterization of ifenprodil and glycine affinities on truncated NMDA receptor .
24464409	0	ifenprodil	59,69	NR2B	35,39	ifenprodil	NR2B	MESH:C010739	2904	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|antagonist antagonist|compound|END_ENTITY	Effect of the N-methyl-D-aspartate NR2B subunit antagonist ifenprodil on precursor cell proliferation in the hippocampus .
9548411	0	ifenprodil	41,51	ornithine_decarboxylase	14,37	ifenprodil	ornithine decarboxylase	MESH:C010739	4953	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of ornithine_decarboxylase by ifenprodil .
18028906	0	ifosfamide	61,71	Thioredoxin_reductase	0,21	ifosfamide	Thioredoxin reductase	MESH:D007069	21672(Tax:10090)	Chemical	Gene	mechanism|nmod|START_ENTITY END_ENTITY|nmod|mechanism	Thioredoxin_reductase inactivation as a pivotal mechanism of ifosfamide in cancer therapy .
9452275	0	ifosfamide	19,29	granulocyte-colony_stimulating_factor	50,87	ifosfamide	granulocyte-colony stimulating factor	MESH:D007069	1440	Chemical	Gene	trial|nmod|START_ENTITY I|dobj|trial I|nmod|END_ENTITY	A Phase I trial of ifosfamide and paclitaxel with granulocyte-colony_stimulating_factor in the treatment of patients with refractory solid tumors .
8808721	0	ifosfamide	119,129	granulocyte_colony-stimulating_factor	29,66	ifosfamide	granulocyte colony-stimulating factor	MESH:D007069	1440	Chemical	Gene	use|nmod|START_ENTITY use|nmod|END_ENTITY	The use of recombinant human granulocyte_colony-stimulating_factor in combination with single or fractionated doses of ifosfamide and doxorubicin in patients with advanced_soft_tissue_sarcoma .
18647323	0	ifosfamide	24,34	interleukin-2	84,97	ifosfamide	interleukin-2	MESH:D007069	3558	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|production production|compound|END_ENTITY	Differential effects of ifosfamide on dendritic cell-mediated stimulation of T cell interleukin-2 production , natural killer cell cytotoxicity and interferon-gamma production .
15370369	0	iganidipine	26,37	Ca2	59,62	iganidipine	Ca2	MESH:C108540	100009156(Tax:9986)	Chemical	Gene	administration|nmod|START_ENTITY administration|appos|antagonist antagonist|compound|END_ENTITY	Topical administration of iganidipine , a new water-soluble Ca2 + antagonist , increases ipsilateral optic nerve head circulation in rabbits and cynomolgus_monkeys .
16848314	0	iguratimod	22,32	TNFalpha	36,44	iguratimod	TNFalpha	MESH:C519076	24835(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	-LSB- Inhibitory effect of iguratimod on TNFalpha production and NF-kappaB activity in LPS-stimulated rat alveolar macrophage cell line -RSB- .
22121776	0	ilexonin_A	14,24	bFGF	46,50	ilexonin A	bFGF	MESH:C043587	54250(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Influence of ilexonin_A on the expression of bFGF , GAP-43 and neurogenesis after cerebral_ischemia-reperfusion in rats -RSB- .
15621812	0	imatinib	28,36	ABL	53,56	imatinib	ABL	MESH:C097613	25	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	In vitro drug resistance to imatinib and mutation of ABL gene in childhood Philadelphia chromosome-positive -LRB- Ph + -RRB- acute_lymphoblastic_leukemia .
15927253	0	imatinib	91,99	BCR-ABL	103,110	imatinib	BCR-ABL	MESH:C097613	25	Chemical	Gene	START_ENTITY|nmod|patients patients|amod|END_ENTITY	Treatment of elderly patients with acute_lymphoblastic_leukemia -- evidence for a benefit of imatinib in BCR-ABL positive patients .
17006667	0	imatinib	8,16	BCR-ABL	39,46	imatinib	BCR-ABL	MESH:C097613	25	Chemical	Gene	resistance|amod|START_ENTITY END_ENTITY|nsubj|resistance	Not all imatinib resistance in CML are BCR-ABL kinase domain mutations .
19091403	0	imatinib	22,30	BCR-ABL	64,71	imatinib	BCR-ABL	MESH:C097613	25	Chemical	Gene	response|nmod|START_ENTITY END_ENTITY|nsubj|response	Molecular response to imatinib in patient with Ph negative p190 BCR-ABL transcript positive chronic_myeloid_leukemia with cyclic_leukocytosis .
21347248	0	imatinib	93,101	BCR-ABL	136,143	imatinib	BCR-ABL	MESH:C097613	25	Chemical	Gene	sensitivity|amod|START_ENTITY sensitivity|nmod|END_ENTITY	Interplay between kinase domain autophosphorylation and F-actin binding domain in regulating imatinib sensitivity and nuclear import of BCR-ABL .
15126780	0	imatinib	77,85	C-kit	0,5	imatinib	C-kit	MESH:C097613	3815	Chemical	Gene	therapy|nmod|START_ENTITY expression|dep|therapy expression|amod|END_ENTITY	C-kit expression in sarcomatoid_renal_cell_carcinoma : potential therapy with imatinib .
19096980	0	imatinib	62,70	C-kit	10,15	imatinib	C-kit	MESH:C097613	3815	Chemical	Gene	resistance|nmod|START_ENTITY cause|nmod|resistance cause|nsubj|mutation mutation|amod|END_ENTITY	Secondary C-kit mutation is a cause of acquired resistance to imatinib in gastrointestinal_stromal_tumor .
24577437	0	imatinib	84,92	CD117	0,5	imatinib	CD117	MESH:C097613	3815	Chemical	Gene	participates|xcomp|START_ENTITY participates|nsubj|expression expression|compound|END_ENTITY	CD117 -LRB- c-kit -RRB- expression on CD34 + cells participates in the cytogenetic response to imatinib in patients with chronic_myeloid_leukemia in the first chronic phase .
19394750	0	imatinib	88,96	CD34	73,77	imatinib	CD34	MESH:C097613	947	Chemical	Gene	sensitize|nmod|START_ENTITY sensitize|dobj|cells cells|compound|END_ENTITY	Inhibition of MDR1 does not sensitize primitive chronic_myeloid_leukemia CD34 + cells to imatinib .
26693810	0	imatinib	47,55	CYP3A	8,13	imatinib	CYP3A	MESH:C097613	1576	Chemical	Gene	activity|nmod|START_ENTITY END_ENTITY|nsubj|activity	In vivo CYP3A activity and pharmacokinetics of imatinib in relation to therapeutic outcome in chronic_myeloid_leukemia patients .
26898422	0	imatinib	32,40	Heme_oxygenase-1	0,16	imatinib	Heme oxygenase-1	MESH:C097613	3162	Chemical	Gene	contributes|xcomp|START_ENTITY contributes|nsubj|END_ENTITY	Heme_oxygenase-1 contributes to imatinib resistance by promoting autophagy in chronic_myeloid_leukemia through disrupting the mTOR signaling pathway .
20959405	0	imatinib	77,85	IFNG	4,8	imatinib	IFNG	MESH:C097613	3458	Chemical	Gene	predicts|advcl|START_ENTITY predicts|nsubj|END_ENTITY	The IFNG -LRB- IFN-gamma -RRB- genotype predicts cytogenetic and molecular response to imatinib therapy in chronic_myeloid_leukemia .
14677065	0	imatinib	76,84	KIT	5,8	imatinib	KIT	MESH:C097613	3815	Chemical	Gene	treatment|amod|START_ENTITY usefulness|nmod|treatment abrogates|dobj|usefulness abrogates|nsubj|expression expression|compound|END_ENTITY	Rare KIT -LRB- CD117 -RRB- expression in multiple_myeloma abrogates the usefulness of imatinib mesylate treatment .
15070666	0	imatinib	94,102	KIT	6,9	imatinib	KIT	MESH:C097613	3815	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|END_ENTITY	Serum KIT and KIT_ligand levels in patients with gastrointestinal_stromal_tumors treated with imatinib .
15236194	0	imatinib	67,75	KIT	22,25	imatinib	KIT	MESH:C097613	3815	Chemical	Gene	resistance|acl|START_ENTITY causes|dobj|resistance causes|nsubj|mutation mutation|nmod|pocket pocket|compound|END_ENTITY	A new mutation in the KIT ATP pocket causes acquired resistance to imatinib in a gastrointestinal_stromal_tumor patient .
15342366	0	imatinib	59,67	KIT	23,26	imatinib	KIT	MESH:C097613	3815	Chemical	Gene	resistance|amod|START_ENTITY correlates|nmod|resistance kinase|dobj|correlates kinase|nsubj|mutation mutation|nmod|END_ENTITY	A missense mutation in KIT kinase domain 1 correlates with imatinib resistance in gastrointestinal_stromal_tumors .
16183119	0	imatinib	105,113	KIT	26,29	imatinib	KIT	MESH:C097613	3815	Chemical	Gene	responsiveness|acl|START_ENTITY identified|nmod|responsiveness identified|nsubj|mutation mutation|nmod|END_ENTITY	A novel K509I mutation of KIT identified in familial_mastocytosis-in vitro and in vivo responsiveness to imatinib therapy .
16551858	0	imatinib	113,121	KIT	43,46	imatinib	KIT	MESH:C097613	3815	Chemical	Gene	mesylate|amod|START_ENTITY evolution|nmod|mesylate evolution|nmod|mutations mutations|compound|END_ENTITY	Polyclonal evolution of multiple secondary KIT mutations in gastrointestinal_stromal_tumors under treatment with imatinib mesylate .
16786129	0	imatinib	23,31	KIT	46,49	imatinib	KIT	MESH:C097613	3815	Chemical	Gene	mutation|compound|START_ENTITY mutation|compound|END_ENTITY	Acquired resistance to imatinib and secondary KIT exon 13 mutation in gastrointestinal_stromal_tumour .
16842246	0	imatinib	118,126	KIT	0,3	imatinib	KIT	MESH:C097613	3815	Chemical	Gene	evaluated|nmod|START_ENTITY evaluated|nsubj|immunohistochemistry immunohistochemistry|compound|END_ENTITY	KIT immunohistochemistry and mutation status in gastrointestinal_stromal_tumours -LRB- GISTs -RRB- evaluated for treatment with imatinib .
17139461	0	imatinib	115,123	KIT	155,158	imatinib	KIT	MESH:C097613	3815	Chemical	Gene	respect|acl|START_ENTITY management|nmod|respect caused|nsubj|management caused|nmod|mutations mutations|compound|END_ENTITY	Surgical management after neoadjuvant imatinib therapy in gastrointestinal_stromal_tumours -LRB- GISTs -RRB- with respect to imatinib resistance caused by secondary KIT mutations .
17139461	0	imatinib	38,46	KIT	155,158	imatinib	KIT	MESH:C097613	3815	Chemical	Gene	therapy|compound|START_ENTITY management|nmod|therapy caused|nsubj|management caused|nmod|mutations mutations|compound|END_ENTITY	Surgical management after neoadjuvant imatinib therapy in gastrointestinal_stromal_tumours -LRB- GISTs -RRB- with respect to imatinib resistance caused by secondary KIT mutations .
18567837	0	imatinib	64,72	KIT	112,115	imatinib	KIT	MESH:C097613	3815	Chemical	Gene	cutaneous_mastocytosis|nmod|START_ENTITY treatment|nmod|cutaneous_mastocytosis treatment|acl|carrying carrying|dobj|mutation mutation|compound|END_ENTITY	Successful treatment of progressive cutaneous_mastocytosis with imatinib in a 2-year-old boy carrying a somatic KIT mutation .
19182535	0	imatinib	33,41	KIT	89,92	imatinib	KIT	MESH:C097613	3815	Chemical	Gene	efficacy|nmod|START_ENTITY efficacy|nmod|angiosarcoma angiosarcoma|nmod|END_ENTITY	Dramatic and durable efficacy of imatinib in an advanced angiosarcoma without detectable KIT and PDGFRA mutations .
19620409	0	imatinib	112,120	KIT	60,63	imatinib	KIT	MESH:C097613	3815	Chemical	Gene	treatment|amod|START_ENTITY CT|nmod|treatment findings|nmod|CT gastrointestinal_stromal_tumors|dep|findings gastrointestinal_stromal_tumors|nmod|mutations mutations|compound|END_ENTITY	Residual and recurrent gastrointestinal_stromal_tumors with KIT mutations : findings at first follow-up CT after imatinib treatment .
20372153	0	imatinib	33,41	KIT	100,103	imatinib	KIT	MESH:C097613	3815	Chemical	Gene	observed|nmod|START_ENTITY observed|xcomp|expressing expressing|nmod|END_ENTITY	Clinical responses observed with imatinib or sorafenib in melanoma patients expressing mutations in KIT .
21362052	0	imatinib	76,84	KIT	42,45	imatinib	KIT	MESH:C097613	3815	Chemical	Gene	response|nmod|START_ENTITY END_ENTITY|dobj|response	A case of mast_cell_leukaemia with exon 9 KIT mutation and good response to imatinib .
24369323	0	imatinib	15,23	KIT	65,68	imatinib	KIT	MESH:C097613	3815	Chemical	Gene	resistance|amod|START_ENTITY resistance|nmod|status status|nmod|genes genes|compound|END_ENTITY	Correlation of imatinib resistance with the mutational status of KIT and PDGFRA genes in gastrointestinal_stromal_tumors : a meta-analysis .
25003536	0	imatinib	60,68	KIT	14,17	imatinib	KIT	MESH:C097613	3815	Chemical	Gene	START_ENTITY|nsubj|mutation mutation|compound|END_ENTITY	Novel somatic KIT exon 8 mutation with dramatic response to imatinib in a patient with mucosal_melanoma : a case report .
25139846	0	imatinib	95,103	KIT	45,48	imatinib	KIT	MESH:C097613	3815	Chemical	Gene	treatment|nmod|START_ENTITY sensitive|nmod|treatment sensitive|nsubj|Familial_systemic_mastocytosis Familial_systemic_mastocytosis|nmod|mutation mutation|compound|END_ENTITY	Familial_systemic_mastocytosis with germline KIT K509I mutation is sensitive to treatment with imatinib , dasatinib and PKC412 .
25182956	0	imatinib	88,96	KIT	0,3	imatinib	KIT	MESH:C097613	3815	Chemical	Gene	resistance|compound|START_ENTITY heterogeneous|nmod|resistance heterogeneous|nsubj|END_ENTITY	KIT and BRAF heterogeneous mutations in gastrointestinal_stromal_tumors after secondary imatinib resistance .
25222580	11	imatinib	2122,2130	KIT	2096,2099	imatinib	KIT	MESH:C097613	3815	Chemical	Gene	treated|nmod|START_ENTITY treated|advmod|other other|nmod|mutation mutation|compound|END_ENTITY	CONCLUSIONS : The ratio of overall survival of patients with advanced GIST with a mutation other than exon 11 KIT mutation treated with imatinib is similar to the ratio of overall survival of patients with GIST with exon 11 KIT mutation .
25609545	0	imatinib	33,41	KIT	66,69	imatinib	KIT	MESH:C097613	3815	Chemical	Gene	response|nmod|START_ENTITY correlates|nsubj|response correlates|nmod|mutation mutation|compound|END_ENTITY	Metabolic response by FDG-PET to imatinib correlates with exon 11 KIT mutation and predicts outcome in patients with mucosal_melanoma .
25684098	0	imatinib	67,75	KIT	145,148	imatinib	KIT	MESH:C097613	3815	Chemical	Gene	START_ENTITY|nmod|line line|acl|carrying carrying|dobj|mutation mutation|compound|END_ENTITY	Molecular changes associated with the development of resistance to imatinib in an imatinib-sensitive canine neoplastic mast cell line carrying a KIT c. 1523A > T mutation .
26316776	0	imatinib	14,22	KIT	78,81	imatinib	KIT	MESH:C097613	3815	Chemical	Gene	Inactivity|nmod|START_ENTITY Inactivity|acl|harboring harboring|dobj|mutation mutation|compound|END_ENTITY	Inactivity of imatinib in gastrointestinal_stromal_tumors -LRB- GISTs -RRB- harboring a KIT activation-loop domain mutation -LRB- exon 17 mutation pN822K -RRB- .
22282465	0	imatinib	54,62	KRAS	0,4	imatinib	KRAS	MESH:C097613	3845	Chemical	Gene	predict|advcl|START_ENTITY predict|nsubj|mutations mutations|compound|END_ENTITY	KRAS and BRAF mutations predict primary resistance to imatinib in gastrointestinal_stromal_tumors .
18294126	0	imatinib	98,106	P-glycoprotein	8,22	imatinib	P-glycoprotein	MESH:C097613	5243	Chemical	Gene	treated|nmod|START_ENTITY Role|acl|treated Role|nmod|END_ENTITY	Role of P-glycoprotein in evolution of populations of chronic_myeloid_leukemia cells treated with imatinib .
18449471	0	imatinib	138,146	P-gp	14,18	imatinib	P-gp	MESH:C097613	67078(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of P-gp -LRB- Mdr1a/1b -RRB- , BCRP -LRB- Bcrp1 -RRB- and P-gp/BCRP inhibitors on the in vivo absorption , distribution , metabolism and excretion of imatinib .
20701289	0	imatinib	130,138	P-gp	81,85	imatinib	P-gp	MESH:C097613	283871	Chemical	Gene	substrates|nmod|START_ENTITY model|nmod|substrates model|nmod|contribution contribution|nmod|END_ENTITY	A new intestinal cell culture model to discriminate the relative contribution of P-gp and BCRP on transport of substrates such as imatinib .
21418741	0	imatinib	110,118	P-gp	26,30	imatinib	P-gp	MESH:C097613	283871	Chemical	Gene	overexpressing|nmod|START_ENTITY P-gp|acl|overexpressing sensitivity|nmod|P-gp increases|dobj|sensitivity increases|nsubj|Simultaneous Simultaneous|acl|targeting targeting|nmod|END_ENTITY	Simultaneous targeting of P-gp and XIAP with siRNAs increases sensitivity of P-gp overexpressing CML cells to imatinib .
21418741	0	imatinib	110,118	P-gp	77,81	imatinib	P-gp	MESH:C097613	283871	Chemical	Gene	overexpressing|nmod|START_ENTITY END_ENTITY|acl|overexpressing	Simultaneous targeting of P-gp and XIAP with siRNAs increases sensitivity of P-gp overexpressing CML cells to imatinib .
26276287	0	imatinib	29,37	PDGF-Rb	10,17	imatinib	PDGF-Rb	MESH:C097613	18596(Tax:10090)	Chemical	Gene	antagonist|xcomp|START_ENTITY antagonist|nsubj|Effect Effect|nmod|END_ENTITY	Effect of PDGF-Rb antagonist imatinib on endometrial_injury repairing in mouse model .
19301902	0	imatinib	84,92	PDGF-Rbeta	156,166	imatinib	PDGF-Rbeta	MESH:C097613	5159	Chemical	Gene	hybrides|amod|START_ENTITY hybrides|nmod|inhibitors inhibitors|nmod|END_ENTITY	Design of chimeric histone deacetylase - and tyrosine kinase-inhibitors : a series of imatinib hybrides as potent inhibitors of wild-type and mutant BCR-ABL , PDGF-Rbeta , and histone deacetylases .
16960151	0	imatinib	21,29	PDGFRB	47,53	imatinib	PDGFRB	MESH:C097613	5159	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	Durable responses to imatinib in patients with PDGFRB fusion gene-positive and BCR-ABL-negative chronic_myeloproliferative_disorders .
24687085	0	imatinib	105,113	PDGFRB	43,49	imatinib	PDGFRB	MESH:C097613	5159	Chemical	Gene	achieve|nmod|START_ENTITY achieve|nsubj|Patients Patients|nmod|myeloid_malignancies myeloid_malignancies|acl|bearing bearing|dobj|genes genes|amod|END_ENTITY	Patients with myeloid_malignancies bearing PDGFRB fusion genes achieve durable long-term remissions with imatinib .
26455322	0	imatinib	127,135	PDGFRB	0,6	imatinib	PDGFRB	MESH:C097613	5159	Chemical	Gene	oncogenic|xcomp|START_ENTITY oncogenic|nsubj|mutants mutants|compound|END_ENTITY	PDGFRB mutants found in patients with familial_infantile_myofibromatosis or overgrowth_syndrome are oncogenic and sensitive to imatinib .
17986854	0	imatinib	41,49	PDGFRbeta	0,9	imatinib	PDGFRbeta	MESH:C097613	5159	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|END_ENTITY	PDGFRbeta and HIF-1alpha inhibition with imatinib and radioimmunotherapy of experimental prostate_cancer .
23751892	0	imatinib	105,113	RUNX1	69,74	imatinib	RUNX1	MESH:C097613	861	Chemical	Gene	treatment|amod|START_ENTITY END_ENTITY|nmod|treatment	A ZMYM2-FGFR1 8p11 myeloproliferative_neoplasm with a novel nonsense RUNX1 mutation and tumor lysis upon imatinib treatment .
25449787	0	imatinib	56,64	SIRT1	114,119	imatinib	SIRT1	MESH:C097613	23411	Chemical	Gene	effects|nmod|START_ENTITY enhances|dobj|effects enhances|nmod|END_ENTITY	Divalproex_sodium enhances the anti-leukemic effects of imatinib in chronic_myeloid_leukemia cells partly through SIRT1 .
21249316	0	imatinib	23,31	VEGF	51,55	imatinib	VEGF	MESH:C097613	7422	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Synergistic effects of imatinib and carboplatin on VEGF , PDGF and PDGF-Ra / expression in squamous_cell_carcinoma of the head_and_neck in vitro .
24553365	0	imatinib	88,96	VEGF	21,25	imatinib	VEGF	MESH:C097613	7422	Chemical	Gene	treated|nmod|START_ENTITY chronic_myeloid_leukemia|acl|treated patients|nmod|chronic_myeloid_leukemia decreases|nmod|patients decreases|dobj|levels levels|amod|END_ENTITY	Interferon decreases VEGF levels in patients with chronic_myeloid_leukemia treated with imatinib .
21993766	0	imatinib	65,73	b-catenin	31,40	imatinib	b-catenin	MESH:C097613	1499	Chemical	Gene	alteration|nmod|START_ENTITY alteration|nmod|expression expression|amod|END_ENTITY	Chemotherapeutic alteration of b-catenin and c-kit expression by imatinib in p16-positive squamous_cell_carcinoma compared to HPV-negative HNSCC cells in vitro .
22684467	0	imatinib	37,45	b-catenin	0,9	imatinib	b-catenin	MESH:C097613	1499	Chemical	Gene	synergizes|nmod|START_ENTITY synergizes|nsubj|inhibition inhibition|amod|END_ENTITY	b-catenin inhibition synergizes with imatinib to delay CML recurrence .
23233089	0	imatinib	98,106	b-catenin	115,124	imatinib	b-catenin	MESH:C097613	1499	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|amod|END_ENTITY	Downregulation of y-catenin inhibits CML cell growth and potentiates the response of CML cells to imatinib through b-catenin inhibition .
24747551	0	imatinib	117,125	b-catenin	30,39	imatinib	b-catenin	MESH:C097613	1499	Chemical	Gene	evoked|nmod|START_ENTITY survival|acl|evoked promotes|dobj|survival promotes|nsubj|fragment fragment|nmod|END_ENTITY	A calpain-cleaved fragment of b-catenin promotes BCRABL1 + cell survival evoked by autophagy induction in response to imatinib .
17419150	0	imatinib	7,15	c-KIT	35,40	imatinib	c-KIT	MESH:C097613	3815	Chemical	Gene	inhibitors|nmod|START_ENTITY inhibitors|nsubj|END_ENTITY	Beyond imatinib : second generation c-KIT inhibitors for the management of gastrointestinal_stromal_tumors .
22855146	0	imatinib	60,68	c-KIT	29,34	imatinib	c-KIT	MESH:C097613	3815	Chemical	Gene	genes|nmod|START_ENTITY genes|amod|END_ENTITY	Tyrosine-kinase mutations in c-KIT and PDGFR-alpha genes of imatinib na ve adult patients with gastrointestinal_stromal_tumours -LRB- GISTs -RRB- of the stomach and small intestine : relation to tumour-biological risk-profile and long-term outcome .
23456621	0	imatinib	66,74	c-KIT	23,28	imatinib	c-KIT	MESH:C097613	3815	Chemical	Gene	resistance|acl|START_ENTITY contribute|nmod|resistance contribute|nsubj|mutations mutations|nmod|END_ENTITY	Secondary mutations of c-KIT contribute to acquired resistance to imatinib and decrease efficacy of sunitinib in Chinese patients with gastrointestinal_stromal_tumors .
21690468	0	imatinib	42,50	c-Kit	107,112	imatinib	c-Kit	MESH:C097613	3815	Chemical	Gene	trial|nmod|START_ENTITY II|appos|trial mesylate|nsubj|II mesylate|advcl|harboring harboring|dobj|mutation mutation|amod|END_ENTITY	Phase II , open-label , single-arm trial of imatinib mesylate in patients with metastatic_melanoma harboring c-Kit mutation or amplification .
24454763	0	imatinib	69,77	c-Kit	14,19	imatinib	c-Kit	MESH:C097613	16590(Tax:10090)	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of c-Kit is not required for reversal of hyperglycemia by imatinib in NOD mice .
17355866	0	imatinib	31,39	c-Src	0,5	imatinib	c-Src	MESH:C097613	6714	Chemical	Gene	START_ENTITY|nsubj|binds binds|amod|END_ENTITY	c-Src binds to the cancer drug imatinib with an inactive Abl/c-Kit conformation and a distributed thermodynamic penalty .
15637141	0	imatinib	73,81	c-fms	46,51	imatinib	c-fms	MESH:C097613	1436	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Macrophage colony-stimulating factor receptor c-fms is a novel target of imatinib .
15070706	0	imatinib	92,100	c-kit	61,66	imatinib	c-kit	MESH:C097613	3815	Chemical	Gene	associated|nmod|START_ENTITY associated|nmod|mutation mutation|amod|END_ENTITY	A novel form of mastocytosis associated with a transmembrane c-kit mutation and response to imatinib .
16087693	0	imatinib	20,28	c-kit	55,60	imatinib	c-kit	MESH:C097613	3815	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	A phase II trial of imatinib -LRB- ST1571 -RRB- in patients with c-kit expressing relapsed small-cell_lung_cancer : a CALGB and NCCTG study .
16952044	0	imatinib	108,116	c-kit	87,92	imatinib	c-kit	MESH:C097613	3815	Chemical	Gene	treatment|amod|START_ENTITY associated|nmod|treatment associated|nmod|mutation mutation|amod|END_ENTITY	Recurrent gastrointestinal_stromal_tumor -LRB- GIST -RRB- of the stomach associated with a novel c-kit mutation after imatinib treatment .
19636292	0	imatinib	18,26	c-kit	84,89	imatinib	c-kit	MESH:C097613	16590(Tax:10090)	Chemical	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	In vivo effect of imatinib on progression of cecal_GIST-like_tumors in exon 17-type c-kit knock-in mice .
20033343	0	imatinib	13,21	c-kit	67,72	imatinib	c-kit	MESH:C097613	3815	Chemical	Gene	resistance|amod|START_ENTITY resistance|acl|associated associated|nmod|downregulation downregulation|nmod|expression expression|amod|END_ENTITY	Emergence of imatinib resistance associated with downregulation of c-kit expression in recurrent gastrointestinal_stromal_tumor -LRB- GIST -RRB- : optimal timing of resection .
21323568	0	imatinib	99,107	c-kit	36,41	imatinib	c-kit	MESH:C097613	3815	Chemical	Gene	signature|nmod|START_ENTITY characterize|dobj|signature characterize|nsubj|dynamics dynamics|amod|END_ENTITY	Placental_growth_factor and soluble c-kit receptor dynamics characterize the cytokine signature of imatinib in prostate_cancer and bone metastases .
22153896	0	imatinib	75,83	c-kit	39,44	imatinib	c-kit	MESH:C097613	403811(Tax:9615)	Chemical	Gene	therapy|amod|START_ENTITY responsive|nmod|therapy responsive|nsubj|tumor tumor|nmod|mutation mutation|amod|END_ENTITY	Canine intestinal mast cell tumor with c-kit exon 8 mutation responsive to imatinib therapy .
23459373	0	imatinib	118,126	c-kit	21,26	imatinib	c-kit	MESH:C097613	3815	Chemical	Gene	START_ENTITY|nsubj|mutation mutation|amod|END_ENTITY	Extracellular domain c-kit mutation with duplication of Ser501Ala502 found in gastrointestinal_stromal_tumors is more imatinib - and nilotinib-sensitive than that with duplication of Ala502Tyr503 .
24577437	0	imatinib	84,92	c-kit	7,12	imatinib	c-kit	MESH:C097613	3815	Chemical	Gene	participates|xcomp|START_ENTITY participates|nsubj|expression expression|compound|END_ENTITY	CD117 -LRB- c-kit -RRB- expression on CD34 + cells participates in the cytogenetic response to imatinib in patients with chronic_myeloid_leukemia in the first chronic phase .
24635438	0	imatinib	39,47	c-kit	51,56	imatinib	c-kit	MESH:C097613	3815	Chemical	Gene	START_ENTITY|nmod|gastrointestinal_stromal_tumor gastrointestinal_stromal_tumor|amod|END_ENTITY	Significant antitumor effectiveness of imatinib in c-kit negative gastrointestinal_stromal_tumor - case report .
23818358	0	imatinib	10,18	miR-17	0,6	imatinib	miR-17	MESH:C097613	406952	Chemical	Gene	resistance|compound|START_ENTITY END_ENTITY|nmod|resistance	miR-17 in imatinib resistance and response to tyrosine kinase inhibitors in chronic_myeloid_leukemia cells .
20042273	0	imatinib	32,40	p21	0,3	imatinib	p21	MESH:C097613	1026	Chemical	Gene	confers|advcl|START_ENTITY confers|nsubj|END_ENTITY	p21 -LRB- Cip1 -RRB- confers resistance to imatinib in human chronic_myeloid_leukemia cells .
19236722	0	imatinib	35,43	quinone_reductase_2	59,78	imatinib	quinone reductase 2	MESH:C097613	4835	Chemical	Gene	structure|nmod|START_ENTITY bound|nsubj|structure bound|nmod|END_ENTITY	The structure of the leukemia drug imatinib bound to human quinone_reductase_2 -LRB- NQO2 -RRB- .
12975485	0	imatinib_mesilate	15,32	P-glycoprotein	44,58	imatinib mesilate	P-glycoprotein	CHEBI:31690	5243	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of imatinib_mesilate with human P-glycoprotein .
17438106	0	imatinib_mesylate	30,47	ABCG2	108,113	imatinib mesylate	ABCG2	MESH:C097613	9429	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|advcl|inhibiting inhibiting|dobj|END_ENTITY	The tyrosine kinase inhibitor imatinib_mesylate enhances the efficacy of photodynamic therapy by inhibiting ABCG2 .
12538464	0	imatinib_mesylate	81,98	BCR-ABL	53,60	imatinib mesylate	BCR-ABL	MESH:C097613	25	Chemical	Gene	therapy|nmod|START_ENTITY END_ENTITY|nmod|therapy	Quantitative polymerase chain reaction monitoring of BCR-ABL during therapy with imatinib_mesylate -LRB- STI571 ; gleevec -RRB- in chronic-phase chronic myelogenous_leukemia .
23613955	0	imatinib_mesylate	67,84	BCR/ABL	14,21	imatinib mesylate	BCR/ABL	MESH:C097613	25;613	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|expression expression|amod|END_ENTITY	Inhibition of BCR/ABL protein expression by miR-203 sensitizes for imatinib_mesylate .
12655446	0	imatinib_mesylate	12,29	KIT	94,97	imatinib mesylate	KIT	MESH:C097613	3815	Chemical	Gene	Response|nmod|START_ENTITY Response|nmod|END_ENTITY	Response to imatinib_mesylate of a gastrointestinal_stromal_tumor with very low expression of KIT .
16462496	0	imatinib_mesylate	18,35	KIT	91,94	imatinib mesylate	KIT	MESH:C097613	3815	Chemical	Gene	study|nmod|START_ENTITY refractory_germ_cell_tumors|nsubj|study refractory_germ_cell_tumors|xcomp|expressing expressing|dobj|END_ENTITY	Phase II study of imatinib_mesylate in chemotherapy refractory_germ_cell_tumors expressing KIT .
18235121	0	imatinib_mesylate	83,100	KIT	189,192	imatinib mesylate	KIT	MESH:C097613	3815	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	Long-term results from a randomized phase II trial of standard - versus higher-dose imatinib_mesylate for patients with unresectable or metastatic gastrointestinal_stromal_tumors expressing KIT .
19276970	0	imatinib_mesylate	78,95	KIT	31,34	imatinib mesylate	KIT	MESH:C097613	3815	Chemical	Gene	use|nmod|START_ENTITY positivity|nmod|use positivity|compound|END_ENTITY	Merkel_cell_carcinoma : lack of KIT positivity and implications for the use of imatinib_mesylate .
14501388	0	imatinib_mesylate	133,150	Kit	14,17	imatinib mesylate	Kit	MESH:C097613	3815	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|receptors receptors|amod|END_ENTITY	Expression of Kit and platelet-derived growth factor receptors alpha and beta in cholangiocarcinoma , and case report of therapy with imatinib_mesylate -LRB- STI571 -RRB- .
17173066	0	imatinib_mesylate	87,104	Kit	62,65	imatinib mesylate	Kit	MESH:C097613	16590(Tax:10090)	Chemical	Gene	resistant|xcomp|START_ENTITY mutants|xcomp|resistant mutants|nsubj|Semaxinib Semaxinib|nmod|agent agent|acl|targeting targeting|dobj|END_ENTITY	Semaxinib -LRB- SU5416 -RRB- as a therapeutic agent targeting oncogenic Kit mutants resistant to imatinib_mesylate .
19735720	0	imatinib_mesylate	51,68	P-glycoprotein	86,100	imatinib mesylate	P-glycoprotein	MESH:C097613	5243	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Cyclosporin_A sensitises Bcr-Abl positive cells to imatinib_mesylate independently of P-glycoprotein expression .
17705809	0	imatinib_mesylate	50,67	PDGFR	31,36	imatinib mesylate	PDGFR	MESH:C097613	5159	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of tyrosine kinases PDGFR and C-Kit by imatinib_mesylate interferes with postnatal testicular development in the rat .
23127398	0	imatinib_mesylate	37,54	PTEN	80,84	imatinib mesylate	PTEN	MESH:C097613	5728	Chemical	Gene	START_ENTITY|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Effect of tyrosine kinase inhibitor imatinib_mesylate on K562 cell invasion by PTEN pathway -RSB- .
15310776	0	imatinib_mesylate	50,67	Platelet-derived_growth_factor_receptor	0,39	imatinib mesylate	Platelet-derived growth factor receptor	MESH:C097613	5159	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Platelet-derived_growth_factor_receptor inhibitor imatinib_mesylate and docetaxel : a modular phase I trial in androgen-independent_prostate_cancer .
16014680	0	imatinib_mesylate	39,56	c-kit	14,19	imatinib mesylate	c-kit	MESH:C097613	3815	Chemical	Gene	kinase|nmod|START_ENTITY kinase|amod|END_ENTITY	Inhibition of c-kit tyrosine kinase by imatinib_mesylate induces apoptosis in mast cells in rheumatoid_synovia : a potential approach to the treatment of arthritis .
16809884	0	imatinib_mesylate	10,27	granulocyte_colony-stimulating_factor	42,79	imatinib mesylate	granulocyte colony-stimulating factor	MESH:C097613	1440	Chemical	Gene	Effect|nmod|START_ENTITY combined|nsubj|Effect combined|nmod|END_ENTITY	Effect of imatinib_mesylate combined with granulocyte_colony-stimulating_factor on leukaemic blast cells derived from advanced-stage_chronic_myelogenous_leukaemia patients .
1322856	0	imidapril	71,80	ACE	45,48	imidapril	ACE	MESH:C065166	24310(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY inhibitory|dobj|effect inhibitory|nsubj|Studies Studies|appos|END_ENTITY	-LSB- Studies on angiotensin_I_converting_enzyme -LRB- ACE -RRB- inhibitory effect of imidapril .
14594552	0	imidapril	99,108	ACE	84,87	imidapril	ACE	MESH:C065166	24310(Tax:10116)	Chemical	Gene	cyclase|xcomp|START_ENTITY cyclase|nmod|inhibitor inhibitor|compound|END_ENTITY	Attenuation of changes in G -LRB- i -RRB- - proteins and adenylyl cyclase in heart_failure by an ACE inhibitor , imidapril .
7735253	0	imidapril	107,116	ACE	52,55	imidapril	ACE	MESH:C065166	1636	Chemical	Gene	model|nmod|START_ENTITY tissue-angiotensin_I_converting_enzyme|dep|model tissue-angiotensin_I_converting_enzyme|appos|END_ENTITY	A saturable tissue-angiotensin_I_converting_enzyme -LRB- ACE -RRB- binding model for the pharmacokinetic analysis of imidapril , a new ACE inhibitor , and its active metabolite in human .
8076891	0	imidapril	72,81	ACE	45,48	imidapril	ACE	MESH:C065166	24310(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY Studies|dep|effect Studies|nmod|angiotensin_I_converting_enzyme angiotensin_I_converting_enzyme|appos|END_ENTITY	-LSB- Studies on angiotensin_I_converting_enzyme -LRB- ACE -RRB- : inhibitory effect of imidapril , a novel ACE inhibitor -LRB- II -RRB- .
8076891	0	imidapril	72,81	ACE	91,94	imidapril	ACE	MESH:C065166	24310(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	-LSB- Studies on angiotensin_I_converting_enzyme -LRB- ACE -RRB- : inhibitory effect of imidapril , a novel ACE inhibitor -LRB- II -RRB- .
8198936	0	imidapril	26,35	ACE	43,46	imidapril	ACE	MESH:C065166	1636	Chemical	Gene	studies|nmod|START_ENTITY studies|dep|inhibitor inhibitor|compound|END_ENTITY	Dose finding studies with imidapril -- a new ACE inhibitor .
9134274	11	imidapril	1529,1538	ACE	1515,1518	imidapril	ACE	MESH:C065166	1636	Chemical	Gene	START_ENTITY|nsubj|inhibitor inhibitor|compound|END_ENTITY	CONCLUSION : The ACE inhibitor imidapril modified fibrinolysis , but the effects occurred after the inhibition of serum ACE activity .
9857856	0	imidapril	107,116	ACE	22,25	imidapril	ACE	MESH:C065166	1636	Chemical	Gene	study|nmod|START_ENTITY High|dep|study High|dep|inhibition inhibition|compound|END_ENTITY	High - versus low-dose ACE inhibition in chronic_heart_failure : a double-blind , placebo-controlled study of imidapril .
17884087	0	imidapril	23,32	MMP-9	81,86	imidapril	MMP-9	MESH:C065166	4318	Chemical	Gene	mechanism|nmod|START_ENTITY mechanism|nmod|END_ENTITY	Molecular mechanism of imidapril for cardiovascular protection via inhibition of MMP-9 .
16097368	0	imidapril	21,30	aminopeptidase_P	48,64	imidapril	aminopeptidase P	MESH:C065166	11820(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activity activity|compound|END_ENTITY	Different effects of imidapril and enalapril on aminopeptidase_P activity in the mouse trachea .
1642667	0	imidapril	61,70	angiotensin-I-converting_enzyme	19,50	imidapril	angiotensin-I-converting enzyme	MESH:C065166	100009274(Tax:9986)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Effects of the new angiotensin-I-converting_enzyme inhibitor imidapril on the responses of isolated vascular preparations to various agonists .
11549204	0	imidapril	88,97	angiotensin-converting_enzyme	48,77	imidapril	angiotensin-converting enzyme	MESH:C065166	1636	Chemical	Gene	START_ENTITY|nsubj|interactions interactions|nmod|inhibitor inhibitor|amod|END_ENTITY	Pharmacokinetic and dynamic interactions of the angiotensin-converting_enzyme inhibitor imidapril with hydrochlorothiazide , bisoprolol and nilvadipine .
12177688	0	imidapril	43,52	angiotensin-converting_enzyme	66,95	imidapril	angiotensin-converting enzyme	MESH:C065166	1636	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Protection of the cardiovascular system by imidapril , a versatile angiotensin-converting_enzyme inhibitor .
12963679	0	imidapril	88,97	angiotensin-converting_enzyme	48,77	imidapril	angiotensin-converting enzyme	MESH:C065166	11421(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|nitric_oxide nitric_oxide|nmod|effect effect|nmod|inhibitor inhibitor|amod|END_ENTITY	Important role of nitric_oxide in the effect of angiotensin-converting_enzyme inhibitor imidapril on vascular_injury .
1322673	0	imidapril	59,68	angiotensin-converting_enzyme	19,48	imidapril	angiotensin-converting enzyme	MESH:C065166	610668(Tax:9615)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Effects of the new angiotensin-converting_enzyme inhibitor imidapril on renal hemodynamics and function in anesthetized dogs .
1642668	0	imidapril	66,75	angiotensin-converting_enzyme	26,55	imidapril	angiotensin-converting enzyme	MESH:C065166	24310(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|fate fate|nmod|inhibitor inhibitor|amod|END_ENTITY	Metabolic fate of the new angiotensin-converting_enzyme inhibitor imidapril in animals .
8923331	0	imidapril	91,100	angiotensin-converting_enzyme	108,137	imidapril	angiotensin-converting enzyme	MESH:C065166	24310(Tax:10116)	Chemical	Gene	metabolite|nmod|START_ENTITY pharmacokinetics|appos|metabolite pharmacokinetics|appos|inhibitor inhibitor|amod|END_ENTITY	Steady-state pharmacokinetics and pharmacodynamics of imidaprilat , an active metabolite of imidapril , a new angiotensin-converting_enzyme inhibitor in spontaneously hypertensive rats .
9278890	0	imidapril	82,91	angiotensin-converting_enzyme	99,128	imidapril	angiotensin-converting enzyme	MESH:C065166	24310(Tax:10116)	Chemical	Gene	metabolite|nmod|START_ENTITY study|appos|metabolite study|appos|inhibitor inhibitor|amod|END_ENTITY	Pharmacokinetic and pharmacodynamic study of imidaprilat , an active metabolite of imidapril , a new angiotensin-converting_enzyme inhibitor , in spontaneously hypertensive rats .
9278891	0	imidapril	93,102	angiotensin-converting_enzyme	110,139	imidapril	angiotensin-converting enzyme	MESH:C065166	24310(Tax:10116)	Chemical	Gene	Pharmacokinetics|amod|START_ENTITY Pharmacokinetics|appos|inhibitor inhibitor|amod|END_ENTITY	Pharmacokinetics and pharmacodynamics of a sustained-release biodegradable pellet containing imidapril , a new angiotensin-converting_enzyme inhibitor in spontaneously hypertensive rats .
9602958	0	imidapril	74,83	angiotensin-converting_enzyme	33,62	imidapril	angiotensin-converting enzyme	MESH:C065166	1636	Chemical	Gene	START_ENTITY|nsubj|trial trial|nmod|inhibitor inhibitor|amod|END_ENTITY	Cough-challenge trial with a new angiotensin-converting_enzyme inhibitor , imidapril .
21814211	0	imidapril	58,67	angiotensin_II	8,22	imidapril	angiotensin II	MESH:C065166	183	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Role Role|nmod|END_ENTITY	Role of angiotensin_II in plasma PAI-1 changes induced by imidapril or candesartan in hypertensive patients with metabolic_syndrome .
19888787	0	imidapril	105,114	angiotensin_II_type_1_receptor	118,148	imidapril	angiotensin II type 1 receptor	MESH:C065166	185	Chemical	Gene	START_ENTITY|nmod|therapy therapy|amod|END_ENTITY	Effect on the atherogenic marker plasminogen_activator_inhibitor_type-1 of addition of the ACE inhibitor imidapril to angiotensin_II_type_1_receptor antagonist therapy in hypertensive patients with abnormal glucose metabolism : a prospective cohort study in primary care .
24096831	0	imidapril	57,66	matrix_metalloproteinase-9	16,42	imidapril	matrix metalloproteinase-9	MESH:C065166	17395(Tax:10090)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Significance of matrix_metalloproteinase-9 inhibition by imidapril for prevention of abdominal_aortic_aneurysms in angiotensin II type 1 receptor-knockout mice .
9398110	0	imidapril	59,68	plasminogen_activator_inhibitor	79,110	imidapril	plasminogen activator inhibitor	MESH:C065166	5054	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	The effects of the angiotensin-converting enzyme inhibitor imidapril on plasma plasminogen_activator_inhibitor activity in patients with acute myocardial_infarction .
10836729	0	imidapril	24,33	plasminogen_activator_inhibitor-1	63,96	imidapril	plasminogen activator inhibitor-1	MESH:C065166	24617(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Differential effects of imidapril and candesartan_cilexetil on plasminogen_activator_inhibitor-1 expression induced by prolonged inhibition of nitric_oxide synthesis in rat hearts .
8923331	0	imidaprilat	54,65	angiotensin-converting_enzyme	108,137	imidaprilat	angiotensin-converting enzyme	MESH:C078006	24310(Tax:10116)	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY pharmacokinetics|appos|inhibitor inhibitor|amod|END_ENTITY	Steady-state pharmacokinetics and pharmacodynamics of imidaprilat , an active metabolite of imidapril , a new angiotensin-converting_enzyme inhibitor in spontaneously hypertensive rats .
9278890	0	imidaprilat	45,56	angiotensin-converting_enzyme	99,128	imidaprilat	angiotensin-converting enzyme	MESH:C078006	24310(Tax:10116)	Chemical	Gene	study|nmod|START_ENTITY study|appos|inhibitor inhibitor|amod|END_ENTITY	Pharmacokinetic and pharmacodynamic study of imidaprilat , an active metabolite of imidapril , a new angiotensin-converting_enzyme inhibitor , in spontaneously hypertensive rats .
23107482	0	imidazo-pyrrolopyridine	45,68	JAK1	69,73	imidazo-pyrrolopyridine	JAK1	null	3716	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Structure-based discovery of C-2 substituted imidazo-pyrrolopyridine JAK1 inhibitors with improved selectivity over JAK2 .
21775820	0	imidazoacridinone_C-1311	11,35	HIF-1a	74,80	imidazoacridinone C-1311	HIF-1a	null	15251(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Anticancer imidazoacridinone_C-1311 inhibits hypoxia-inducible factor-1a -LRB- HIF-1a -RRB- , vascular endothelial growth factor -LRB- VEGF -RRB- and angiogenesis .
12901915	1	imidazobenzodiazepines	108,130	PARP-1	141,147	imidazobenzodiazepines	PARP-1	null	142	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Part 4 : biological evaluation of imidazobenzodiazepines as potent PARP-1 inhibitors for treatment of ischemic_injuries .
16079529	0	imidazole	16,25	5-lipoxygenase	26,40	imidazole	5-lipoxygenase	MESH:C029899	240	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Optimization of imidazole 5-lipoxygenase inhibitors and selection and synthesis of a development candidate .
3841572	0	imidazole	95,104	cytochrome_P-450	28,44	imidazole	cytochrome P-450	MESH:C029899	25251(Tax:10116)	Chemical	Gene	drugs|amod|START_ENTITY testis|nmod|drugs testis|nsubj|Inhibition Inhibition|nmod|enzymes enzymes|amod|END_ENTITY	Inhibition of steroidogenic cytochrome_P-450 enzymes in rat testis by ketoconazole and related imidazole anti-fungal drugs .
4297287	0	imidazole	10,19	insulin	25,32	imidazole	insulin	MESH:C029899	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of imidazole upon insulin secretion .
14758763	0	imidazole	54,63	p38	64,67	imidazole	p38	MESH:C029899	1432	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nummod|END_ENTITY	Synthetic methodology utilized to prepare substituted imidazole p38 MAP kinase inhibitors .
10377223	0	imidazole	84,93	p38_mitogen-activated_protein_kinase	108,144	imidazole	p38 mitogen-activated protein kinase	MESH:C029899	81649(Tax:10116)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Design and synthesis of potent , selective , and orally bioavailable tetrasubstituted imidazole inhibitors of p38_mitogen-activated_protein_kinase .
6260821	0	imidazole	71,80	tyrosinase	35,45	imidazole	tyrosinase	MESH:C029899	7299	Chemical	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	Regulation of cell division and of tyrosinase in B16 melanoma cells by imidazole : a possible role for the concept of metabolite gene regulation in mammalian cells .
341150	0	imidazole-glycerolphosphate	122,149	his3	163,167	imidazole-glycerolphosphate	his3	null	854377(Tax:4932)	Chemical	Gene	dehydratase|amod|START_ENTITY dehydratase|appos|END_ENTITY	Production of a functional eukaryotic enzyme in Escherichia_coli : cloning and expression of the yeast structural gene for imidazole-glycerolphosphate dehydratase -LRB- his3 -RRB- .
19539471	0	imidazoles	22,32	dipeptidyl_peptidase-IV	36,59	imidazoles	dipeptidyl peptidase-IV	MESH:D007093	1803	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Aminopiperidine-fused imidazoles as dipeptidyl_peptidase-IV inhibitors .
3593236	0	imidazoles	61,71	dopamine_beta-mono-oxygenase	15,43	imidazoles	dopamine beta-mono-oxygenase	MESH:D007093	1621	Chemical	Gene	START_ENTITY|nsubj|Interaction Interaction|nmod|END_ENTITY	Interaction of dopamine_beta-mono-oxygenase with substituted imidazoles and pyrazoles .
22150679	0	imidazoline	90,101	AKT	116,119	imidazoline	AKT	CHEBI:53094	24185(Tax:10116)	Chemical	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Dexmedetomidine protects against oxygen-glucose_deprivation-induced injury through the I2 imidazoline receptor-PI3K / AKT pathway in rat C6 glioma cells .
24582883	0	imidazoline	32,43	NF-kB	93,98	imidazoline	NF-kB	D048288	81736(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Pharmacological benefit of I -LRB- 1 -RRB- - imidazoline receptors activation and nuclear_factor_kappa-B -LRB- NF-kB -RRB- modulation in experimental Huntington 's _ disease .
16678176	0	imidazoline	26,37	Nischarin	0,9	imidazoline	Nischarin	CHEBI:53094	306255(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	Nischarin as a functional imidazoline -LRB- I1 -RRB- receptor .
20832472	0	imidazoline	35,46	monoamine_oxidase-B	72,91	imidazoline	monoamine oxidase-B	D048288	4129	Chemical	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	On the formation and nature of the imidazoline I2 binding site on human monoamine_oxidase-B .
22426510	0	imidazoline	10,21	monoamine_oxidase_B	30,49	imidazoline	monoamine oxidase B	CHEBI:53094	4129	Chemical	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Targeting imidazoline site on monoamine_oxidase_B through molecular docking simulations .
9380016	0	imidazoline	20,31	monoamine_oxidase_B	50,69	imidazoline	monoamine oxidase B	CHEBI:53094	4129	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Localization of the imidazoline binding domain on monoamine_oxidase_B .
8343989	0	imidazolium	15,26	acetylcholinesterase	74,94	imidazolium	acetylcholinesterase	CHEBI:50059	43	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of imidazolium and pyridinium_dioximes with human erythrocyte acetylcholinesterase .
26879855	0	imidazolium	15,26	paraoxonase_1	56,69	imidazolium	paraoxonase 1	CHEBI:50059	5444	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Functionalized imidazolium and benzimidazolium salts as paraoxonase_1 inhibitors : Synthesis , characterization and molecular docking studies .
18481009	0	imidazolone	45,56	COX-2	82,87	imidazolone	COX-2	MESH:C117197	26198(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Synthesis and biological evaluation of novel imidazolone derivatives as potential COX-2 inhibitors .
17368021	0	imidazolones	29,41	tumor_necrosis_factor-alpha_converting_enzyme	85,130	imidazolones	tumor necrosis factor-alpha converting enzyme	CHEBI:20432	6868	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Hydantoins , triazolones , and imidazolones as selective non-hydroxamate inhibitors of tumor_necrosis_factor-alpha_converting_enzyme -LRB- TACE -RRB- .
20833042	0	imidazolopyrimidine	38,57	DPP4	58,62	imidazolopyrimidine	DPP4	null	1803	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Synthesis , SAR , and atropisomerism of imidazolopyrimidine DPP4 inhibitors .
7384171	0	imidazolylthiocarbamides	4,28	guanine_deaminase	32,49	imidazolylthiocarbamides	guanine deaminase	null	9615	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	New imidazolylthiocarbamides as guanine_deaminase inhibitors .
17430637	0	imidazolyluracil	56,72	thymidine_phosphorylase	108,131	imidazolyluracil	thymidine phosphorylase	null	1890	Chemical	Gene	derivatives|amod|START_ENTITY evaluation|nmod|derivatives evaluation|nmod|inhibitors inhibitors|nmod|END_ENTITY	Design , synthesis and enzymatic evaluation of 6-bridged imidazolyluracil derivatives as inhibitors of human thymidine_phosphorylase .
22971111	0	imidazopyrazine	16,31	Aurora_A	47,55	imidazopyrazine	Aurora A	CHEBI:37847	6790	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	QSAR studies on imidazopyrazine derivatives as Aurora_A kinase inhibitors .
24922544	0	imidazopyridine	40,55	CDC25	86,91	imidazopyridine	CDC25	CHEBI:46908	995	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|compound|END_ENTITY	Discovery and characterization of novel imidazopyridine derivative CHEQ-2 as a potent CDC25 inhibitor and promising anticancer drug candidate .
23820386	0	imidazopyridine	51,66	PI3K	81,85	imidazopyridine	PI3K	CHEBI:46908	5293	Chemical	Gene	START_ENTITY|dobj|inhibitors inhibitors|nmod|END_ENTITY	Structure guided optimization of a fragment hit to imidazopyridine inhibitors of PI3K .
20128619	0	imidazopyridine	56,71	dipeptidyl_peptidase_IV	72,95	imidazopyridine	dipeptidyl peptidase IV	CHEBI:46908	1803	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	Asymmetric synthesis of a potent , aminopiperidine-fused imidazopyridine dipeptidyl_peptidase_IV inhibitor .
8388468	0	imidazopyridines	50,66	Cyclic_nucleotide_phosphodiesterase	0,35	imidazopyridines	Cyclic nucleotide phosphodiesterase	CHEBI:46908	5140	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Cyclic_nucleotide_phosphodiesterase inhibition by imidazopyridines : analogues of sulmazole and isomazole as inhibitors of the cGMP specific phosphodiesterase .
12643929	0	imidazopyridines	13,29	leukotriene_A4_hydrolase	66,90	imidazopyridines	leukotriene A4 hydrolase	CHEBI:46908	16993(Tax:10090)	Chemical	Gene	Synthesis|nmod|START_ENTITY Synthesis|nmod|END_ENTITY	Synthesis of imidazopyridines and purines as potent inhibitors of leukotriene_A4_hydrolase .
22481916	0	imidazoquinoline	42,58	Toll-like_receptor_7	0,20	imidazoquinoline	Toll-like receptor 7	CHEBI:38776	170743(Tax:10090)	Chemical	Gene	therapy|nmod|START_ENTITY therapy|amod|END_ENTITY	Toll-like_receptor_7 agonist therapy with imidazoquinoline enhances cancer cell death and increases_lymphocytic_infiltration and proinflammatory cytokine production in established tumors of a renal_cell_carcinoma mouse model .
23394863	0	imidazoquinoline	51,67	mPGES-1	83,90	imidazoquinoline	mPGES-1	CHEBI:38776	64292(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Synthesis and biological evaluation of substituted imidazoquinoline derivatives as mPGES-1 inhibitors .
18337121	0	imidazoquinoline_S-27609	63,87	Toll-like_receptor_7	102,122	imidazoquinoline S-27609	Toll-like receptor 7	null	106586812	Chemical	Gene	START_ENTITY|appos|ligand ligand|nmod|END_ENTITY	Induction of interferon system genes in Atlantic_salmon by the imidazoquinoline_S-27609 , a ligand for Toll-like_receptor_7 .
24383475	0	imidazoquinolines	44,61	Toll-like_receptors_7_and_8	67,94	imidazoquinolines	Toll-like receptors 7 and 8	CHEBI:38776	51284;51311	Chemical	Gene	START_ENTITY|nmod|selectivity selectivity|compound|END_ENTITY	Structure-activity relationship analysis of imidazoquinolines with Toll-like_receptors_7_and_8 selectivity and enhanced cytokine induction .
18007421	0	imide	4,9	5-HT1A_receptor	10,25	imide	5-HT1A receptor	CHEBI:24782	3350	Chemical	Gene	ligands|amod|START_ENTITY ligands|amod|END_ENTITY	New imide 5-HT1A_receptor ligands - modification of terminal fragment geometry .
23147262	0	imidoselenocarbamates	40,61	selenoprotein	65,78	imidoselenocarbamates	selenoprotein	null	93684(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Structure - and cell-specific effects of imidoselenocarbamates on selenoprotein expression and activity in liver cells in culture .
19657969	0	imino	55,60	SLC6A20	74,81	imino	SLC6A20	CHEBI:29342	54716	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Sodium translocation by the iminoglycinuria associated imino transporter -LRB- SLC6A20 -RRB- .
5913841	0	iminodibenzyl	11,24	insulin	89,96	iminodibenzyl	insulin	MESH:C005051	100009181(Tax:9986)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Effect of iminodibenzyl on the level of blood sugar in rabbits during administration of insulin , adrenaline , noradrenaline and glucose -RSB- .
22390835	0	iminohydantoin	26,40	BACE1	41,46	iminohydantoin	BACE1	null	29392(Tax:10116)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Structure based design of iminohydantoin BACE1 inhibitors : identification of an orally available , centrally active BACE1 inhibitor .
26195137	0	iminohydantoin_spiropiperidine	26,56	BACE-1	70,76	iminohydantoin spiropiperidine	BACE-1	null	23621	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Methyl-substitution of an iminohydantoin_spiropiperidine b-secretase -LRB- BACE-1 -RRB- inhibitor has a profound effect on its potency .
26195137	0	iminohydantoin_spiropiperidine	26,56	BACE-1	70,76	iminohydantoin spiropiperidine	BACE-1	null	23621	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Methyl-substitution of an iminohydantoin_spiropiperidine b-secretase -LRB- BACE-1 -RRB- inhibitor has a profound effect on its potency .
11230808	0	imipramine	141,151	Bcl-2	218,223	imipramine	Bcl-2	MESH:D007099	596	Chemical	Gene	induced|nmod|START_ENTITY induced|nmod|END_ENTITY	Changes in the generation of reactive oxygen species and in mitochondrial membrane potential during apoptosis induced by the antidepressants imipramine , clomipramine , and citalopram and the effects on these changes by Bcl-2 and Bcl-X -LRB- L -RRB- .
22326584	0	imipramine	40,50	CXCL1	70,75	imipramine	CXCL1	MESH:D007099	81503(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Inhibitory effect of the antidepressant imipramine on NF-kB-dependent CXCL1 expression in TNFa-exposed astrocytes .
8335704	0	imipramine	14,24	CYP2D6	45,51	imipramine	CYP2D6	MESH:D007099	1565	Chemical	Gene	START_ENTITY|acl|vitro vitro|nmod|END_ENTITY	Metabolism of imipramine in vitro by isozyme CYP2D6 expressed in a human cell line , and observations on metabolite stability .
10445381	0	imipramine	110,120	FMO3	101,105	imipramine	FMO3	MESH:D007099	2328	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of arginine-428 mutation on modulation of activity of human liver flavin_monooxygenase_3 -LRB- FMO3 -RRB- by imipramine and chlorpromazine .
9603221	0	imipramine	20,30	SERT1	115,120	imipramine	SERT1	MESH:D007099	246151(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY mediated|nsubj|effects mediated|nmod|END_ENTITY	Distinct effects of imipramine on 5-hydroxytryptamine uptake mediated by the recombinant rat serotonin transporter SERT1 .
9361724	0	imipramine	8,18	acetylcholinesterase	48,68	imipramine	acetylcholinesterase	MESH:D007099	83817(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Chronic imipramine treatment-induced changes in acetylcholinesterase -LRB- EC 3.1.1.7 -RRB- activity in discrete rat brain regions .
16382205	0	imipramine	24,34	brain-derived_neurotrophic_factor	83,116	imipramine	brain-derived neurotrophic factor	MESH:D007099	24225(Tax:10116)	Chemical	Gene	treatment|nmod|START_ENTITY induces|nsubj|treatment induces|dobj|expression expression|amod|END_ENTITY	Combined treatment with imipramine and metyrapone induces hippocampal and cortical brain-derived_neurotrophic_factor gene expression in rats .
17622693	0	imipramine	27,37	brain-derived_neurotrophic_factor	73,106	imipramine	brain-derived neurotrophic factor	MESH:D007099	24225(Tax:10116)	Chemical	Gene	co-treatment|nmod|START_ENTITY induces|nsubj|co-treatment induces|dobj|expression expression|amod|END_ENTITY	Repeated co-treatment with imipramine and amantadine induces hippocampal brain-derived_neurotrophic_factor gene expression in rats .
10487422	0	imipramine	20,30	caspase-3	126,135	imipramine	caspase-3	MESH:D007099	836	Chemical	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	The antidepressants imipramine , clomipramine , and citalopram induce apoptosis in human acute_myeloid_leukemia HL-60 cells via caspase-3 activation .
15996564	0	imipramine	21,31	corticotropin-releasing-hormone	45,76	imipramine	corticotropin-releasing-hormone	MESH:D007099	1392	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Inhibitory effect of imipramine on the human corticotropin-releasing-hormone gene promoter activity operates through a PI3-K/AKT mediated pathway .
5947700	0	imipramine	29,39	insulin	53,60	imipramine	insulin	MESH:D007099	3630	Chemical	Gene	START_ENTITY|nmod|content content|compound|END_ENTITY	-LSB- Studies on the influence of imipramine on the serum insulin content in depressive schizophrenics -RSB- .
8842333	0	imipramine	46,56	insulin	87,94	imipramine	insulin	MESH:D007099	100009181(Tax:9986)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Different effects of the antidepressant drugs imipramine , maprotiline and bupropion on insulin secretion from mouse pancreatic islets .
12609461	0	imipramine	74,84	interleukin-1beta	88,105	imipramine	interleukin-1beta	MESH:D007099	24494(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	Differential effect of a single high dose of the tricyclic antidepressant imipramine on interleukin-1beta and tumor_necrosis_factor-alpha secretion following an in vivo lipopolysaccharide challenge in rats .
2248074	0	imipramine	62,72	monoamine_oxidase-A	25,44	imipramine	monoamine oxidase-A	MESH:D007099	4128	Chemical	Gene	inhibitor|nmod|START_ENTITY inhibitor|amod|END_ENTITY	Efficacy of a reversible monoamine_oxidase-A inhibitor versus imipramine in subgroups of depressed patients .
2521644	0	imipramine	10,20	prolactin	38,47	imipramine	prolactin	MESH:D007099	5617	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|response response|compound|END_ENTITY	Effect of imipramine treatment on the prolactin response to fenfluramine and placebo challenge in depressed patients .
24404422	0	imiquimod	17,26	TLR7	4,8	imiquimod	TLR7	MESH:C056493	51284	Chemical	Gene	START_ENTITY|nsubj|agonist agonist|compound|END_ENTITY	The TLR7 agonist imiquimod as an adjuvant for radiotherapy-elicited in situ vaccination against breast_cancer .
22577802	0	imiquimod	30,39	Toll-like_receptor_7	0,20	imiquimod	Toll-like receptor 7	MESH:C056493	51284	Chemical	Gene	agonist|acl|START_ENTITY agonist|amod|END_ENTITY	Toll-like_receptor_7 agonist , imiquimod , inhibits oral squamous_carcinoma cells through apoptosis and necrosis .
24521786	0	imiquimod	29,38	Toll-like_receptor_7	0,20	imiquimod	Toll-like receptor 7	MESH:C056493	170743(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|agonist agonist|amod|END_ENTITY	Toll-like_receptor_7 agonist imiquimod in combination with influenza vaccine expedites and augments humoral immune responses against influenza_A -LRB- H1N1 -RRB- pdm09_virus_infection in BALB/c mice .
15611427	0	imiquimod	52,61	toll-like_receptor_7	23,43	imiquimod	toll-like receptor 7	MESH:C056493	51284	Chemical	Gene	agonist|acl|START_ENTITY agonist|amod|END_ENTITY	Psoriasis triggered by toll-like_receptor_7 agonist imiquimod in the presence of dermal plasmacytoid dendritic cell precursors .
16886623	0	incadronate	39,50	caveolin-1	14,24	incadronate	caveolin-1	MESH:C071542	857	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|expression expression|amod|END_ENTITY	Inhibition of caveolin-1 expression by incadronate in PC-3 prostate cells .
25960646	0	indacaterol	17,28	COPD	86,90	indacaterol	COPD	MESH:C510790	260431	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of combined indacaterol and glycopyrronium_bromide -LRB- QVA149 -RRB- for the treatment of COPD in Japan .
19422388	0	indacaterol	36,47	beta_2-adrenoceptor	57,76	indacaterol	beta 2-adrenoceptor	MESH:C510790	154	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Pharmacogenetic characterization of indacaterol , a novel beta_2-adrenoceptor agonist .
22542282	0	indane	19,25	thyroid_hormone_receptor_b	57,83	indane	thyroid hormone receptor b	CHEBI:37911	6957	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	Discovery of novel indane derivatives as liver-selective thyroid_hormone_receptor_b -LRB- TRb -RRB- agonists for the treatment of dyslipidemia .
21211972	0	indanone_oximes	43,58	B-Raf	83,88	indanone oximes	B-Raf	null	673	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	The discovery of furo -LSB- 2,3-c -RSB- pyridine-based indanone_oximes as potent and selective B-Raf inhibitors .
16137794	0	indanones	62,71	AChE	39,43	indanones	AChE	MESH:D007189	43	Chemical	Gene	inhibitors|nmod|START_ENTITY inhibitors|amod|END_ENTITY	Synthesis and biological evaluation as AChE inhibitors of new indanones and thiaindanones related to donepezil .
12925048	0	indapamide	57,67	ACE	112,115	indapamide	ACE	MESH:D007190	1636	Chemical	Gene	START_ENTITY|nmod|patients patients|acl|receiving receiving|dobj|END_ENTITY	Comparative metabolic effects of hydrochlorothiazide and indapamide in hypertensive diabetic patients receiving ACE inhibitor therapy .
17926468	0	indapamide	101,111	ACE	34,37	indapamide	ACE	MESH:D007190	1636	Chemical	Gene	inhibitor|nmod|START_ENTITY inhibitor|nsubj|Clinical Clinical|nmod|END_ENTITY	-LSB- Clinical and vascular effects of ACE inhibitor enalapril in combination with thiaside-like diuretic indapamide in hypertensive outpatients .
20573778	0	indapamide	45,55	ACE	61,64	indapamide	ACE	MESH:D007190	1636	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	The effect of treatment based on a diuretic -LRB- indapamide -RRB- + / - ACE inhibitor -LRB- perindopril -RRB- on fractures in the Hypertension in the Very Elderly Trial -LRB- HYVET -RRB- .
17600705	0	indazoles	54,63	Lck	49,52	indazoles	Lck	MESH:D007191	3932	Chemical	Gene	inhibitors|dep|START_ENTITY inhibitors|nmod|END_ENTITY	N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of Lck : indazoles as phenol isosteres with improved pharmacokinetics .
21742493	0	indazoles	13,22	Tpl2	40,44	indazoles	Tpl2	MESH:D007191	1326	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Discovery of indazoles as inhibitors of Tpl2 kinase .
21767952	0	indazoles	64,73	ketohexokinase	77,91	indazoles	ketohexokinase	MESH:D007191	3795	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Optimization of a pyrazole hit from FBDD into a novel series of indazoles as ketohexokinase inhibitors .
17624777	0	indene_N-oxide	55,69	peroxisome_proliferator_activated_receptor_gamma	92,140	indene N-oxide	peroxisome proliferator activated receptor gamma	null	5468	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Synthesis and structure-activity relationship of novel indene_N-oxide derivatives as potent peroxisome_proliferator_activated_receptor_gamma -LRB- PPARgamma -RRB- agonists .
17034134	0	indenoisoquinoline	28,46	topoisomerase_I	47,62	indenoisoquinoline	topoisomerase I	null	7150	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Synthesis and evaluation of indenoisoquinoline topoisomerase_I inhibitors substituted with nitrogen heterocycles .
25776905	0	indenoisoquinoline	31,49	topoisomerase_I	50,65	indenoisoquinoline	topoisomerase I	null	477229(Tax:9615)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	Plasma pharmacokinetics of the indenoisoquinoline topoisomerase_I inhibitor , NSC_743400 , in rats and dogs .
19383846	0	indenoisoquinoline_noncamptothecin	4,38	topoisomerase_I	39,54	indenoisoquinoline noncamptothecin	topoisomerase I	null	7150	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	The indenoisoquinoline_noncamptothecin topoisomerase_I inhibitors : update and perspectives .
17696418	0	indenoisoquinolines	9,28	topoisomerase_I	32,47	indenoisoquinolines	topoisomerase I	null	7150	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Nitrated indenoisoquinolines as topoisomerase_I inhibitors : a systematic study and optimization .
22079759	0	indenoisoquinolines	46,65	topoisomerase_I	69,84	indenoisoquinolines	topoisomerase I	null	7150	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Synthesis and biological evaluations of novel indenoisoquinolines as topoisomerase_I inhibitors .
11754595	0	indenoisoquinolinium_chloride	54,83	topoisomerase_I	84,99	indenoisoquinolinium chloride	topoisomerase I	null	7150	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Synthesis of new dihydroindeno -LSB- 1,2-c -RSB- isoquinoline and indenoisoquinolinium_chloride topoisomerase_I inhibitors having high in vivo anticancer activity in the hollow fiber animal model .
16890327	0	indenopyrazole	23,37	cyclin_dependent_kinase_4	53,78	indenopyrazole	cyclin dependent kinase 4	CHEBI:46869	1019	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	3D-QSAR CoMFA study on indenopyrazole derivatives as cyclin_dependent_kinase_4 -LRB- CDK4 -RRB- and cyclin_dependent_kinase_2 -LRB- CDK2 -RRB- inhibitors .
12410055	6	indinavir	963,972	CYP2D6	884,890	indinavir	CYP3A4	MESH:D019469	1576	Chemical	Gene	inhibitors|dep|START_ENTITY inhibitors|nummod|END_ENTITY	Possible interactions with CYP2D6 inhibitors -LRB- amiodarone , fluoxetine or ritonavir -RRB- and CYP3A4 inhibitors -LRB- indinavir and ritonavir -RRB- can increase its serum concentrations and produce significant adverse effects .
17517050	0	indinavir	83,92	MDR1	18,22	indinavir	MDR1	MESH:D019469	5243	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY polymorphisms|nmod|pharmacokinetics polymorphisms|nsubj|effect effect|nmod|END_ENTITY	Minimal effect of MDR1 and CYP3A5 genetic polymorphisms on the pharmacokinetics of indinavir in HIV-infected patients .
24719186	0	indinavir	27,36	MT1-MMP	89,96	indinavir	MT1-MMP	MESH:D019469	4323	Chemical	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|nmod|END_ENTITY	The HIV protease inhibitor indinavir down-regulates the expression of the pro-angiogenic MT1-MMP by human endothelial cells .
20951181	0	indirubin	24,33	aryl_hydrocarbon_receptor	81,106	indirubin	aryl hydrocarbon receptor	MESH:C027185	25690(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Differential effects of indirubin and 2,3,7,8-tetrachlorodibenzo-p-dioxin on the aryl_hydrocarbon_receptor -LRB- AhR -RRB- signalling in liver progenitor cells .
10045324	0	indium_gallium_arsenide	47,70	EL2	25,28	indium gallium arsenide	EL2	null	6708	Chemical	Gene	defect|nmod|START_ENTITY defect|compound|END_ENTITY	First observation of the EL2 lattice defect in indium_gallium_arsenide grown by molecular-beam epitaxy .
670360	0	indocyanine_green	63,80	albumin	36,43	indocyanine green	albumin	MESH:D007208	213	Chemical	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	Electrophoretic bimorphism of serum albumin in the presence of indocyanine_green .
23098218	0	indocyanine_green	41,58	p-glycoprotein	83,97	indocyanine green	p-glycoprotein	MESH:D007208	610926(Tax:9615)	Chemical	Gene	Evaluation|nmod|START_ENTITY Evaluation|nmod|END_ENTITY	Evaluation of the near infrared compound indocyanine_green as a probe substrate of p-glycoprotein .
17920088	0	indol-3-acetonitrile	21,41	ESP	0,3	indol-3-acetonitrile	ESP	null	841842(Tax:3702)	Chemical	Gene	production|amod|START_ENTITY mediate|dobj|production mediate|nsubj|END_ENTITY	ESP and ESM1 mediate indol-3-acetonitrile production from indol-3-ylmethyl_glucosinolate in Arabidopsis .
10798223	0	indol-3-carbinol	102,118	cytochrome_P-450_1A1	58,78	indol-3-carbinol	cytochrome P-450 1A1	null	24296(Tax:10116)	Chemical	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	N-methoxyindole-3-carbinol is a more efficient inducer of cytochrome_P-450_1A1 in cultured cells than indol-3-carbinol .
17920088	0	indol-3-ylmethyl_glucosinolate	58,88	ESP	0,3	indol-3-ylmethyl glucosinolate	ESP	CHEBI:29028	841842(Tax:3702)	Chemical	Gene	mediate|advcl|START_ENTITY mediate|nsubj|END_ENTITY	ESP and ESM1 mediate indol-3-acetonitrile production from indol-3-ylmethyl_glucosinolate in Arabidopsis .
24308997	0	indole	42,48	AKT	64,67	indole	AKT	MESH:C030374	207	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	Design , synthesis and evaluation of novel indole derivatives as AKT inhibitors .
19249138	0	indole	71,77	CB1	101,104	indole	CB1	MESH:C030374	1268	Chemical	Gene	ligands|amod|START_ENTITY ligands|nmod|END_ENTITY	Development of CoMFA and CoMSIA models of affinity and selectivity for indole ligands of cannabinoid CB1 and CB2 receptors .
17908921	0	indole	52,58	CYP2A6	14,20	indole	CYP2A6	MESH:C030374	403149(Tax:9823)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Regulation of CYP2A6 protein expression by skatole , indole , and testicular steroids in primary cultured pig hepatocytes .
20079636	0	indole	45,51	PPARgamma	88,97	indole	PPARgamma	MESH:C030374	5468	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	Synthesis and biological activities of novel indole derivatives as potent and selective PPARgamma modulators .
17416521	0	indole	57,63	X_receptor	85,95	indole	X receptor	MESH:C030374	9213	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Discovery and structure-activity relationship studies of indole derivatives as liver X_receptor -LRB- LXR -RRB- agonists .
22425563	0	indole	56,62	acetylcholinesterase	12,32	indole	acetylcholinesterase	MESH:C030374	43	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Prospective acetylcholinesterase inhibitory activity of indole and its analogs .
18951803	0	indole	82,88	monoamine_oxidases_A_and_B	103,129	indole	monoamine oxidases A and B	MESH:C030374	4128;4129	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|nmod|END_ENTITY	Synthesis , structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine_oxidases_A_and_B .
11231045	0	indole	60,66	non-pancreatic_secretory_phospholipase_A2	87,128	indole	non-pancreatic secretory phospholipase A2	MESH:C030374	5320	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	A molecular modeling and 3D QSAR study of a large series of indole inhibitors of human non-pancreatic_secretory_phospholipase_A2 .
23315198	0	indole	25,31	phospholipase_A	49,64	indole	phospholipase A	MESH:C030374	57110	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	Interactions of selected indole derivatives with phospholipase_A : in silico and in vitro analysis .
17559277	0	indole	109,115	phospholipase_A2	130,146	indole	phospholipase A2	MESH:C030374	151056	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Regioselective synthesis of 4 - _ and_7-alkoxyindoles from 2,3-dihalophenols : application to the preparation of indole inhibitors of phospholipase_A2 .
21138791	0	indole	71,77	serine_protease	111,126	indole	serine protease	MESH:C030374	2147	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|nmod|END_ENTITY	Molecular modeling based approach , synthesis and in vitro assay to new indole inhibitors of hepatitis_C NS3/4A serine_protease .
11719698	0	indole-3-carbinol	27,44	CYP1A1	80,86	indole-3-carbinol	CYP1A1	MESH:C016517	24296(Tax:10116)	Chemical	Gene	exposure|nmod|START_ENTITY induces|nsubj|exposure induces|dobj|expression expression|nmod|END_ENTITY	Transplacental exposure to indole-3-carbinol induces sex-specific expression of CYP1A1 and CYP1B1 in the liver of Fischer 344 neonatal rats .
17311112	0	indole-3-carbinol	14,31	CYP1A1	53,59	indole-3-carbinol	CYP1A1	MESH:C016517	1543	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	The effect of indole-3-carbinol on the expression of CYP1A1 , CYP1B1 and AhR genes and proliferation of MCF-7 cells .
24771368	0	indole-3-carbinol	158,175	CYP1A1	90,96	indole-3-carbinol	CYP1A1	MESH:C016517	24296(Tax:10116)	Chemical	Gene	influence|nmod|START_ENTITY -3|nmod|influence -3|nmod|induction induction|nmod|activity activity|nmod|genes genes|compound|END_ENTITY	Effect of polyunsaturated_fatty_acids -3 on the induction of activity and expression of CYP1A1 and CYP1A2 genes in the liver of rats under the influence of indole-3-carbinol .
15027113	0	indole-3-carbinol	33,50	MUC1	14,18	indole-3-carbinol	MUC1	MESH:C016517	4582	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|expression expression|compound|END_ENTITY	Inhibition of MUC1 expression by indole-3-carbinol .
21837756	0	indole-3-carbinol	28,45	TRAMP	131,136	indole-3-carbinol	TRAMP	MESH:C016517	85030(Tax:10090)	Chemical	Gene	mice|amod|START_ENTITY mice|appos|END_ENTITY	In vivo pharmacodynamics of indole-3-carbinol in the inhibition_of_prostate_cancer in transgenic adenocarcinoma of mouse prostate -LRB- TRAMP -RRB- mice : involvement of Nrf2 and cell cycle/apoptosis signaling pathways .
10652612	0	indole-3-carbinol	41,58	p53	77,80	indole-3-carbinol	p53	MESH:C016517	7157	Chemical	Gene	cells|nmod|START_ENTITY apoptosis|nmod|cells Induction|nmod|apoptosis independent|nsubj|Induction independent|nmod|END_ENTITY	Induction of apoptosis in MCF-7 cells by indole-3-carbinol is independent of p53 and bax .
9608743	0	indole-3-pyruvate	36,53	Sp7	102,105	indole-3-pyruvate	Sp7	CHEBI:17640	121340	Chemical	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Identification and isolation of the indole-3-pyruvate decarboxylase gene from Azospirillum brasilense Sp7 : sequencing and functional analysis of the gene locus .
21714741	0	indole_alkaloid	49,64	acetylcholinesterase	107,127	indole alkaloid	acetylcholinesterase	CHEBI:38958	43	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|compound|END_ENTITY	Geissoschizine_methyl_ether , a corynanthean-type indole_alkaloid from Uncaria rhynchophylla as a potential acetylcholinesterase inhibitor .
11605676	0	indole_alkaloid	83,98	nNOS	38,42	indole alkaloid	nNOS	CHEBI:38958	4842	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|appos|END_ENTITY	Novel neuronal nitric_oxide synthase -LRB- nNOS -RRB- selective inhibitor , aplysinopsin-type indole_alkaloid , from marine sponge Hyrtios erecta .
12014674	0	indoleamine	41,52	IDO	70,73	indoleamine	IDO	CHEBI:28626	3620	Chemical	Gene	START_ENTITY|dobj|activity activity|appos|END_ENTITY	Interleukin-12 and interleukin-18 induce indoleamine 2,3-dioxygenase -LRB- IDO -RRB- activity in human osteosarcoma cell lines independently from interferon-gamma .
1469778	0	indoleamine	78,89	IDO	107,110	indoleamine	IDO	CHEBI:28626	3620	Chemical	Gene	responsible|nmod|START_ENTITY mechanism|amod|responsible 2,3-dioxygenase|nmod:npmod|mechanism 2,3-dioxygenase|dep|END_ENTITY	-LSB- The signal transduction mechanism responsible for interferon-gamma-inducible indoleamine 2,3-dioxygenase -LRB- IDO -RRB- gene expression in T98G cells -RSB- .
19155537	0	indoleamine	10,21	IDO	39,42	indoleamine	IDO	CHEBI:28626	3620	Chemical	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Increased indoleamine 2,3-dioxygenase -LRB- IDO -RRB- activity and elevated serum levels of tryptophan catabolites in patients with chronic_kidney_disease : a possible link between chronic inflammation and uraemic symptoms .
19519465	0	indoleamine	10,21	IDO	39,42	indoleamine	IDO	CHEBI:28626	3620	Chemical	Gene	START_ENTITY|xcomp|2,3-dioxygenase 2,3-dioxygenase|dep|END_ENTITY	Targeting indoleamine 2,3-dioxygenase -LRB- IDO -RRB- to counteract tumour-induced immune_dysfunction : from biochemistry to clinical development .
20739070	0	indoleamine	21,32	IDO	50,53	indoleamine	IDO	CHEBI:28626	15930(Tax:10090)	Chemical	Gene	2,3-dioxygenase|amod|START_ENTITY role|nmod|2,3-dioxygenase role|appos|END_ENTITY	A potential role for indoleamine 2,3-dioxygenase -LRB- IDO -RRB- in Rhodococcus_equi_infection .
21617756	0	indoleamine	46,57	IDO	77,80	indoleamine	IDO	CHEBI:28626	3620	Chemical	Gene	4|nmod|START_ENTITY 4|dep|gene gene|appos|END_ENTITY	Is the variant c. 422 +90 G __ > __ A in intron 4 of indoleamine 2 , 3 - dioxygenase -LRB- IDO -RRB- gene related to age related cataracts ?
23473453	0	indoleamine	48,59	IDO	77,80	indoleamine	IDO	CHEBI:28626	3620	Chemical	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Benznidazole treatment reduces the induction of indoleamine 2,3-dioxygenase -LRB- IDO -RRB- enzymatic activity in Chagas_disease symptomatic patients .
7523670	2	indoleamine	324,335	IDO	349,352	indoleamine	IDO	CHEBI:28626	3620	Chemical	Gene	dioxygenase|amod|START_ENTITY dioxygenase|appos|END_ENTITY	Interferon_gamma -LRB- IFN-gamma -RRB- has antitumor cell activity related to stimulation of 2,3 indoleamine dioxygenase -LRB- IDO -RRB- , a widely distributed tryptophan catabolizing enzyme .
23942267	0	indoleamine	50,61	STAT1	93,98	indoleamine	STAT1	CHEBI:28626	6772	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Sodium_butyrate inhibits interferon-gamma induced indoleamine 2,3-dioxygenase expression via STAT1 in nasopharyngeal_carcinoma cells .
8663541	0	indoleamine	135,146	STAT1	60,65	indoleamine	STAT1	CHEBI:28626	6772	Chemical	Gene	gene|amod|START_ENTITY expression|nmod|gene elements|nmod|expression role|dep|elements role|appos|END_ENTITY	Cooperative role of interferon_regulatory_factor_1 and p91 -LRB- STAT1 -RRB- response elements in interferon-gamma-inducible expression of human indoleamine 2,3-dioxygenase gene .
10926204	0	indoleamine	3,14	stat1	63,68	indoleamine	stat1	CHEBI:28626	6772	Chemical	Gene	mutant|amod|START_ENTITY mutant|acl:relcl|defective defective|nmod|DNA DNA|amod|END_ENTITY	An indoleamine 2,3-dioxygenase-negative mutant is defective in stat1 DNA binding : differential response to IFN-gamma and IFN-alpha .
9682270	0	indoleamines	40,52	CYP1A2	14,20	indoleamines	CYP1A2	null	1544	Chemical	Gene	activity|nmod|START_ENTITY activity|nummod|END_ENTITY	Modulation of CYP1A2 enzyme activity by indoleamines : inhibition by serotonin and tryptamine .
9878816	0	indoleamines	103,115	interleukin-6	12,25	indoleamines	interleukin-6	null	16193(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	The role of interleukin-6 in the activation of the hypothalamo-pituitary-adrenocortical axis and brain indoleamines by endotoxin and interleukin-1_beta .
23514631	0	indoleamines	15,27	isoprenylcysteine_carboxyl_methyltransferase	63,107	indoleamines	isoprenylcysteine carboxyl methyltransferase	null	23463	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Functionalized indoleamines as potent , drug-like inhibitors of isoprenylcysteine_carboxyl_methyltransferase -LRB- Icmt -RRB- .
10476875	0	indoles	12,19	FLAP	83,87	indoles	FLAP	MESH:D007211	241	Chemical	Gene	START_ENTITY|dobj|inhibitors inhibitors|appos|END_ENTITY	Substituted indoles as potent and orally active 5-lipoxygenase activating protein -LRB- FLAP -RRB- inhibitors .
10509757	0	indoles	114,121	flavin-containing_monooxygenase_form_3	41,79	indoles	flavin-containing monooxygenase form 3	MESH:D007211	2328	Chemical	Gene	START_ENTITY|nsubj|inhibition inhibition|nmod|END_ENTITY	In vitro and in vivo inhibition of human flavin-containing_monooxygenase_form_3 -LRB- FMO3 -RRB- in the presence of dietary indoles .
14684325	0	indolin-2-ones	59,73	Src	112,115	indolin-2-ones	Src	null	6714	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Design and synthesis of aminopropyl_tetrahydroindole-based indolin-2-ones as selective and potent inhibitors of Src and Yes tyrosine kinase .
24899257	0	indolines	44,53	aldosterone_synthase	90,110	indolines	aldosterone synthase	null	1585	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Novel pyridyl - or isoquinolinyl-substituted indolines and indoles as potent and selective aldosterone_synthase inhibitors .
18717540	0	indolinone	57,67	3-phosphoinositide-dependent_protein_kinase-1	97,142	indolinone	3-phosphoinositide-dependent protein kinase-1	CHEBI:51625	5170	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|inhibitors inhibitors|nmod|END_ENTITY	Combined 3D-QSAR modeling and molecular docking study on indolinone derivatives as inhibitors of 3-phosphoinositide-dependent_protein_kinase-1 .
18780147	0	indolinone	42,52	PDK1	67,71	indolinone	PDK1	CHEBI:51625	5163	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Structure-based CoMFA and CoMSIA study of indolinone inhibitors of PDK1 .
16672643	0	indolinone	22,32	cyclin-dependent_kinase_2	33,58	indolinone	cyclin-dependent kinase 2	CHEBI:51625	1017	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	The three-substituted indolinone cyclin-dependent_kinase_2 inhibitor 3 - -LSB- 1 - -LRB- 3H-imidazol-4-yl -RRB- - meth - -LRB- Z -RRB- - ylidene -RSB- -5 - methoxy-1 ,3 - dihydro-indol-2-one -LRB- SU9516 -RRB- kills human leukemia cells via down-regulation of Mcl-1 through a transcriptional mechanism .
26994846	0	indolizine	39,49	nAChR	73,78	indolizine	nAChR	MESH:C035094	1137	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Synthesis and biological activities of indolizine derivatives as alpha-7 nAChR agonists .
12459192	0	indolocarbazole	28,43	ABCG2	0,5	indolocarbazole	ABCG2	CHEBI:51915	9429	Chemical	Gene	confers|advcl|START_ENTITY confers|nsubj|END_ENTITY	ABCG2 confers resistance to indolocarbazole compounds by ATP-dependent transport .
10676638	0	indolocarbazole	3,18	Chk1	57,61	indolocarbazole	Chk1	CHEBI:51915	1111	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	An indolocarbazole inhibitor of human checkpoint_kinase -LRB- Chk1 -RRB- abrogates cell cycle arrest caused by DNA damage .
10676638	0	indolocarbazole	3,18	checkpoint_kinase	38,55	indolocarbazole	checkpoint kinase	CHEBI:51915	1111	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|nmod|END_ENTITY	An indolocarbazole inhibitor of human checkpoint_kinase -LRB- Chk1 -RRB- abrogates cell cycle arrest caused by DNA damage .
10893314	0	indolomorphinan	21,36	kappa-opioid_receptor	56,77	indolomorphinan	kappa-opioid receptor	null	4986	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|nmod|END_ENTITY	Potent and selective indolomorphinan antagonists of the kappa-opioid_receptor .
8723519	0	indoloquinone	70,83	DT-diaphorase	35,48	indoloquinone	DT-diaphorase	null	1728	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Development , pharmacology , role of DT-diaphorase and prospects of the indoloquinone EO9 .
10368814	0	indolyl_glucosinolates	111,133	cytochrome_P-450	14,30	indolyl glucosinolates	cytochrome P-450	null	25251(Tax:10116)	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|expression expression|amod|END_ENTITY	Modulation of cytochrome_P-450 and glutathione_S-transferase isoform expression in vivo by intact and degraded indolyl_glucosinolates .
22204487	0	indolylglyoxylamide	23,42	TSPO	43,47	indolylglyoxylamide	TSPO	null	706	Chemical	Gene	affinity|compound|START_ENTITY affinity|compound|END_ENTITY	Medicinal chemistry of indolylglyoxylamide TSPO high affinity ligands with anxiolytic-like effects .
4453620	0	indomethacin	14,26	15-hydroxyprostaglandin_dehydrogenase	42,79	indomethacin	15-hydroxyprostaglandin dehydrogenase	MESH:D007213	873	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition by indomethacin and aspirin of 15-hydroxyprostaglandin_dehydrogenase in vitro .
182636	0	indomethacin	11,23	ACTH	60,64	indomethacin	ACTH	MESH:D007213	5443	Chemical	Gene	Failure|nmod|START_ENTITY Failure|acl|affect affect|advcl|END_ENTITY	Failure of indomethacin to affect adrenal responsiveness to ACTH in vitro .
197569	0	indomethacin	33,45	ACTH	15,19	indomethacin	ACTH	MESH:D007213	5443	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Stimulation Stimulation|nmod|END_ENTITY	Stimulation of ACTH secretion by indomethacin and reversal by exogenous prostaglandins .
232359	0	indomethacin	82,94	ACTH	40,44	indomethacin	ACTH	MESH:D007213	403659(Tax:9615)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|effect effect|nmod|END_ENTITY	Inhibition of the stimulatory effect of ACTH on adrenal_and_ovarian_blood_flow by indomethacin in the dog .
17054584	0	indomethacin	10,22	Bfl-1	26,31	indomethacin	Bfl-1	MESH:D007213	597	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of indomethacin on Bfl-1 , WISP-1 and proliferating_cell_nuclear_antigen in colon_cancer cell line HCT116 cells .
7026333	0	indomethacin	11,23	C-peptide	51,60	indomethacin	C-peptide	MESH:D007213	3630	Chemical	Gene	Failure|nmod|START_ENTITY Failure|acl|affect affect|dobj|END_ENTITY	Failure of indomethacin to affect arginine-induced C-peptide and glucagon release in insulin-treated diabetics .
19895877	0	indomethacin	73,85	CO2	30,33	indomethacin	CO2	MESH:D007213	717	Chemical	Gene	system|nmod|START_ENTITY system|compound|END_ENTITY	A combinational supercritical CO2 system for nanoparticle preparation of indomethacin .
11085996	8	indomethacin	1654,1666	COX-2	1690,1695	indomethacin	COX-2	MESH:D007213	4513	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|advcl|ineffective ineffective|nsubj|nimesulide nimesulide|compound|END_ENTITY	The biosynthesis was inhibited by indomethacin , whereas the selective COX-2 inhibitor nimesulide was ineffective .
11327079	4	indomethacin	800,812	COX-2	716,721	indomethacin	COX-1	MESH:D007213	5742	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubj|NS-398 NS-398|appos|inhibitor inhibitor|compound|END_ENTITY	NS-398 , a selective COX-2 inhibitor , inhibited PGE2 production by FBS-stimulated cells as completely as indomethacin , a non-selective COX-1 / COX-2 inhibitor .
12481160	0	indomethacin	46,58	COX-2	87,92	indomethacin	COX-2	MESH:D007213	26198(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Healing of duodenal ulcers is not impaired by indomethacin or rofecoxib , the selective COX-2 inhibitor , in rats .
15104355	0	indomethacin	77,89	COX-2	32,37	indomethacin	COX-2	MESH:D007213	26198(Tax:10116)	Chemical	Gene	administration|nmod|START_ENTITY expression|nmod|administration expression|compound|END_ENTITY	Functional mechanism underlying COX-2 expression following administration of indomethacin in rat stomachs : importance of gastric_hypermotility .
15589463	12	indomethacin	1538,1550	COX-2	1473,1478	indomethacin	COX-1	MESH:D007213	17708(Tax:10090)	Chemical	Gene	treatment|compound|START_ENTITY IRI|nmod|treatment IRI|nsubj|END_ENTITY	mRNA COX-2 was up-regulated post IRI and considerable inhibited after indomethacin or rofecoxib treatment .
15730717	0	indomethacin	36,48	COX-2	142,147	indomethacin	COX-2	MESH:D007213	4513	Chemical	Gene	effect|nmod|START_ENTITY associated|nsubj|effect associated|nmod|down-regulation down-regulation|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Proliferation inhibition effect of indomethacin on CML cells associated with down-regulation of phosphorylated STAT1/STAT5 and inhibition of COX-2 expression -RSB- .
16169736	0	indomethacin	37,49	COX-2	64,69	indomethacin	COX-2	MESH:D007213	17709(Tax:10090)	Chemical	Gene	related|nmod|START_ENTITY Indolyl_esters|acl|related inhibitors|nsubj|Indolyl_esters inhibitors|compound|END_ENTITY	Indolyl_esters and amides related to indomethacin are selective COX-2 inhibitors .
16581252	0	indomethacin	36,48	COX-2	80,85	indomethacin	COX-2	MESH:D007213	5743	Chemical	Gene	glycolamide_esters|nmod|START_ENTITY Evaluation|nmod|glycolamide_esters Evaluation|nmod|inhibitors inhibitors|appos|END_ENTITY	Evaluation of glycolamide_esters of indomethacin as potential cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors .
17453399	0	indomethacin	33,45	COX-2	10,15	indomethacin	COX-2	MESH:D007213	4513	Chemical	Gene	inhibitor|nmod|START_ENTITY inhibitor|compound|END_ENTITY	Selective COX-2 inhibitor versus indomethacin for the prevention of heterotopic_ossification after hip replacement : a double-blind randomized trial of 100 patients with 1-year follow-up .
19048402	0	indomethacin	88,100	COX-2	47,52	indomethacin	COX-2	MESH:D007213	5743	Chemical	Gene	expressing|nmod|START_ENTITY END_ENTITY|acl|expressing	Enhancement of 5-fluorouracil efficacy on high COX-2 expressing HCA-7 cells by low dose indomethacin and NS-398 but not on low COX-2 expressing HT-29 cells .
20803081	0	indomethacin	30,42	COX-2	109,114	indomethacin	COX-2	MESH:D007213	5743	Chemical	Gene	suppression|compound|START_ENTITY suppression|nmod|colorectal_cancer_cell_growth colorectal_cancer_cell_growth|nmod|pathway pathway|compound|END_ENTITY	mTOR signaling is involved in indomethacin and nimesulide suppression of colorectal_cancer_cell_growth via a COX-2 independent pathway .
22361134	2	indomethacin	951,963	COX-2	901,906	indomethacin	COX-1	MESH:D007213	4512	Chemical	Gene	contrast|nmod|START_ENTITY inhibitor|nmod|contrast inhibitor|compound|END_ENTITY	Furthermore , compound 20 is a selective COX-2 inhibitor in contrast to the reference drug indomethacin that is a potent and selective COX-1 inhibitor -LRB- COX-1 IC -LRB- 50 -RRB- = 0.13 M ; COX-2 IC -LRB- 50 -RRB- = 6.9 M , COX-2 SI = 0.02 -RRB- .
8955930	0	indomethacin	101,113	COX-2	160,165	indomethacin	COX-2	MESH:D007213	26198(Tax:10116)	Chemical	Gene	using|dobj|START_ENTITY transmission|acl|using -1|nmod|transmission -1|dobj|inhibitor inhibitor|amod|selective selective|amod|END_ENTITY	Analysis of the effects of cyclooxygenase _ -LRB- COX -RRB- -1 and COX-2 in spinal nociceptive transmission using indomethacin , a non-selective COX inhibitor , and NS-398 , a COX-2 selective inhibitor .
8594298	0	indomethacin	10,22	CRH	30,33	indomethacin	CRH	MESH:D007213	81648(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|response response|amod|END_ENTITY	Effect of indomethacin on the CRH - and VP-induced pituitary-adrenocortical response during social stress .
1927294	0	indomethacin	96,108	Catechol-O-methyltransferase	0,28	indomethacin	Catechol-O-methyltransferase	MESH:D007213	1312	Chemical	Gene	effect|nmod|START_ENTITY activity|dep|effect activity|amod|END_ENTITY	Catechol-O-methyltransferase activity in red blood cells in threatened preterm_labor ; effect of indomethacin and nylidrin .
20517705	0	indomethacin	42,54	Cox-2	4,9	indomethacin	Cox-2	MESH:D007213	4513	Chemical	Gene	option|nmod|START_ENTITY drugs|dep|option drugs|compound|END_ENTITY	Are Cox-2 drugs the second line option in indomethacin responsive headaches ?
15963497	0	indomethacin	10,22	E-cadherin	26,36	indomethacin	E-cadherin	MESH:D007213	999	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of indomethacin on E-cadherin and beta-catenin expression in HT-29 colon_cancer cells .
2787301	1	indomethacin	66,78	EGF	55,58	indomethacin	EGF	MESH:D007213	1950	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of EGF and/or indomethacin .
1567397	0	indomethacin	108,120	ET-1	0,4	indomethacin	ET-1	MESH:D007213	403424(Tax:9615)	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|END_ENTITY	ET-1 induced bronchoconstriction in the early phase but not late phase of anesthetized dogs is inhibited by indomethacin and ICI_198615 .
16133044	0	indomethacin	63,75	ET-1	8,12	indomethacin	ET-1	MESH:D007213	1906	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|END_ENTITY	Urinary ET-1 , AVP and sodium in premature infants treated with indomethacin and ibuprofen for patent_ductus_arteriosus .
10424717	0	indomethacin	94,106	Endothelin-1	0,12	indomethacin	Endothelin-1	MESH:D007213	24323(Tax:10116)	Chemical	Gene	gastric_mucosal_injury|nmod|START_ENTITY modulators|nmod|gastric_mucosal_injury modulators|compound|interleukin-4 interleukin-4|compound|END_ENTITY	Endothelin-1 , interleukin-4 and nitric_oxide synthase modulators of gastric_mucosal_injury by indomethacin : effect of antiulcer agents .
15591090	0	indomethacin	154,166	FHIT	94,98	indomethacin	FHIT	MESH:D007213	14198(Tax:10090)	Chemical	Gene	characterization|nmod|START_ENTITY characterization|nmod|expression expression|compound|END_ENTITY	4-Hydroxybutyl -LRB- butyl -RRB- nitrosamine-induced urinary_bladder_cancers in mice : characterization of FHIT and survivin expression and chemopreventive effects of indomethacin .
7845555	0	indomethacin	125,137	IL-11	34,39	indomethacin	IL-11	MESH:D007213	171040(Tax:10116)	Chemical	Gene	antagonized|nmod|START_ENTITY antagonized|nsubjpass|Fever Fever|acl|produced produced|nmod|END_ENTITY	Fever produced by interleukin-11 -LRB- IL-11 -RRB- injected into the anterior hypothalamic pre-optic area of the rat is antagonized by indomethacin .
9566801	0	indomethacin	35,47	IL-11	100,105	indomethacin	IL-11	MESH:D007213	3589	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|production production|compound|END_ENTITY	Differential inhibitory effects of indomethacin , dexamethasone , and interferon-gamma -LRB- IFN-gamma -RRB- on IL-11 production by rheumatoid_synovial cells .
10772282	0	indomethacin	10,22	IL-1beta	26,34	indomethacin	IL-1beta	MESH:D007213	3553	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|production production|compound|END_ENTITY	Effect of indomethacin on IL-1beta , IL-6 and TNFalpha production by mononuclear cells of preterm newborns and adults .
11696205	0	indomethacin	11,23	L-selectin	31,41	indomethacin	L-selectin	MESH:D007213	6402	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|amod|END_ENTITY	Effects of indomethacin on the L-selectin expression in humans .
11324902	0	indomethacin	61,73	MUC5AC	0,6	indomethacin	MUC5AC	MESH:D007213	4586	Chemical	Gene	effects|nmod|START_ENTITY release|dep|effects release|compound|END_ENTITY	MUC5AC mucin release from human airways in vitro : effects of indomethacin and Bay X1005 .
22268531	0	indomethacin	41,53	PKR	81,84	indomethacin	PKR	MESH:D007213	5610	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	The non-steroidal anti-inflammatory drug indomethacin activates the eIF2a kinase PKR , causing a translational block in human colorectal_cancer cells .
25856684	0	indomethacin	43,55	PKR	118,121	indomethacin	PKR	MESH:D007213	5610	Chemical	Gene	translation|nmod|START_ENTITY Inhibition|nmod|translation Inhibition|dep|role role|nmod|END_ENTITY	Inhibition of viral protein translation by indomethacin in vesicular_stomatitis virus infection : role of eIF2a kinase PKR .
3893341	0	indomethacin	62,74	Renin	0,5	indomethacin	Renin	MESH:D007213	403838(Tax:9615)	Chemical	Gene	pretreated|nmod|START_ENTITY pretreated|nsubj|response response|compound|END_ENTITY	Renin response to captopril in conscious dogs pretreated with indomethacin or propranolol .
7105627	0	indomethacin	10,22	angiotensin_II	50,64	indomethacin	angiotensin II	MESH:D007213	183	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|END_ENTITY	Effect of indomethacin on responses to -LSB- sar-ileu -RSB- - angiotensin_II .
3033687	0	indomethacin	14,26	angiotensin_converting_enzyme	52,81	indomethacin	angiotensin converting enzyme	MESH:D007213	554335(Tax:9940)	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nsubj|effect	The effect of indomethacin on plasma and lung lymph angiotensin_converting_enzyme activity in sheep .
1836782	0	indomethacin	14,26	atrial_natriuretic_factor	65,90	indomethacin	atrial natriuretic factor	MESH:D007213	4878	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|levels levels|compound|END_ENTITY	The effect of indomethacin on basal and saline-stimulated plasma atrial_natriuretic_factor levels in normal man .
1138295	0	indomethacin	11,23	bradykinin	56,66	indomethacin	bradykinin	MESH:D007213	3827	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of indomethacin on venoconstrictor responses to bradykinin and norepinephrine .
2547411	0	indomethacin	14,26	bradykinin	70,80	indomethacin	bradykinin	MESH:D007213	3827	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|response response|nmod|END_ENTITY	The effect of indomethacin and enalapril on the cutaneous response to bradykinin .
6794012	0	indomethacin	17,29	bradykinin	58,68	indomethacin	bradykinin	MESH:D007213	3827	Chemical	Gene	influence|nmod|START_ENTITY influence|nmod|responses responses|nmod|END_ENTITY	The influence of indomethacin on vasodilator responses to bradykinin and nitroglycerin in the cat .
679427	0	indomethacin	41,53	bradykinin	97,107	indomethacin	bradykinin	MESH:D007213	478666(Tax:9615)	Chemical	Gene	synthesis|nmod|START_ENTITY Inhibition|nmod|synthesis augments|nsubj|Inhibition augments|advcl|END_ENTITY	Inhibition of prostaglandin synthesis by indomethacin augments the renal vasodilator response to bradykinin in the anesthetized dog .
7079557	0	indomethacin	60,72	bradykinin	10,20	indomethacin	bradykinin	MESH:D007213	478666(Tax:9615)	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|Effect Effect|nmod|END_ENTITY	Effect of bradykinin on renal function in dogs treated with indomethacin or propranolol .
8436153	0	indomethacin	100,112	bradykinin	61,71	indomethacin	bradykinin	MESH:D007213	3827	Chemical	Gene	pretreatment|nmod|START_ENTITY END_ENTITY|nmod|pretreatment	Cutaneous blood flow changes and weal induced by intradermal bradykinin following pretreatment with indomethacin and captopril .
7713169	0	indomethacin	78,90	c-Fos	19,24	indomethacin	c-Fos	MESH:D007213	314322(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY expression|dep|effects expression|amod|END_ENTITY	Carrageenin-evoked c-Fos expression in rat lumbar spinal cord : the effects of indomethacin .
12646303	0	indomethacin	10,22	c-fos	30,35	indomethacin	c-fos	MESH:D007213	314322(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effect of indomethacin on the c-fos expression in AVP and TH neurons in rat brain induced by lipopolysaccharide .
2201456	0	indomethacin	14,26	c-myc	74,79	indomethacin	c-myc	MESH:D007213	24577(Tax:10116)	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|expression expression|amod|END_ENTITY	Modulation by indomethacin of diethylnitrosamine-induced early changes in c-myc and c-ras expression and late incidence of preneoplastic_lesions in rat liver .
3392987	0	indomethacin	11,23	cathepsin_B	48,59	indomethacin	cathepsin B	MESH:D007213	64529(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|compound|END_ENTITY	Effects of indomethacin and leupeptin on muscle cathepsin_B activity and protein degradation during sepsis .
16756637	0	indomethacin	10,22	cyclooxygenase-2	37,53	indomethacin	cyclooxygenase-2	MESH:D007213	5743	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Effect of indomethacin and selective cyclooxygenase-2 inhibitors on proteinuria and renal function in patients with AA type renal_amyloidosis .
9821840	0	indomethacin	69,81	cyclooxygenase-2	35,51	indomethacin	cyclooxygenase-2	MESH:D007213	442942(Tax:9615)	Chemical	Gene	inhibitor|nmod|START_ENTITY inhibitor|amod|END_ENTITY	Differential effect of a selective cyclooxygenase-2 inhibitor versus indomethacin on renal blood flow in conscious volume-depleted dogs .
9414035	0	indomethacin	36,48	cyclooxygenase_2	73,89	indomethacin	cyclooxygenase 2	MESH:D007213	29527(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Comparative study of the effects of indomethacin and NS-398 , a selective cyclooxygenase_2 inhibitor , on duodenal bicarbonate secretion induced by luminal acidification in rats .
10423059	0	indomethacin	93,105	endothelin-1	8,20	indomethacin	endothelin-1	MESH:D007213	24323(Tax:10116)	Chemical	Gene	injury|compound|START_ENTITY resistance|nmod|injury synthase|nmod|resistance synthase|amod|END_ENTITY	Role of endothelin-1 and constitutive nitric_oxide synthase in gastric mucosal resistance to indomethacin injury : effect of antiulcer agents .
11790384	0	indomethacin	13,25	endothelin-1	40,52	indomethacin	endothelin-1	MESH:D007213	100726197	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|effects effects|nmod|duct duct|amod|END_ENTITY	Influence of indomethacin on effects of endothelin-1 on guinea_pig isolated rings of common bile duct and sphincter of Oddi .
12056553	0	indomethacin	151,163	endothelin-1	69,81	indomethacin	endothelin-1	MESH:D007213	100726197	Chemical	Gene	influence|nmod|START_ENTITY gallbladder|dep|influence guinea_pig|dobj|gallbladder induced|advcl|guinea_pig induced|nmod|S6c S6c|amod|END_ENTITY	Simultaneous changes in intracellular calcium and tension induced by endothelin-1 and sarafotoxin S6c in guinea_pig isolated gallbladder : influence of indomethacin .
1313765	0	indomethacin	66,78	endothelin-1	10,22	indomethacin	endothelin-1	MESH:D007213	1906	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of endothelin-1 in man : pretreatment with nifedipine , with indomethacin and with cyclosporine_A .
8352028	0	indomethacin	61,73	endothelin-1	20,32	indomethacin	endothelin-1	MESH:D007213	1906	Chemical	Gene	modification|nmod|START_ENTITY effects|dep|modification effects|nmod|END_ENTITY	Vascular effects of endothelin-1 in the cat ; modification by indomethacin and L-NAME .
8961079	0	indomethacin	11,23	endothelin-1	82,94	indomethacin	endothelin-1	MESH:D007213	24323(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY arterioles|nsubj|Effects arterioles|nmod|rats rats|amod|END_ENTITY	Effects of indomethacin and iloprost on contraction of the afferent arterioles by endothelin-1 in juxtamedullary nephron preparations from normotensive Wistar-Kyoto and spontaneously hypertensive rats .
9085162	0	indomethacin	123,135	endothelin-1	175,187	indomethacin	endothelin-1	MESH:D007213	24323(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY gastric_mucosal_lesions|acl|induced attenuates|dobj|gastric_mucosal_lesions attenuates|parataxis|END_ENTITY	Bosentan , a novel synthetic mixed-type endothelin receptor antagonist , attenuates acute gastric_mucosal_lesions induced by indomethacin and HCl in the rat : role of endogenous endothelin-1 .
8273807	0	indomethacin	14,26	epidermal_growth_factor	62,85	indomethacin	epidermal growth factor	MESH:D007213	1950	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|nmod|END_ENTITY	The effect of indomethacin on the secretion of human salivary epidermal_growth_factor .
12911628	0	indomethacin	141,153	inducible_nitric_oxide_synthase	91,122	indomethacin	inducible nitric oxide synthase	MESH:D007213	24599(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Lipopolysaccharide-induced dopaminergic cell death in rat midbrain slice cultures : role of inducible_nitric_oxide_synthase and protection by indomethacin .
1435286	0	indomethacin	17,29	insulin	104,111	indomethacin	insulin	MESH:D007213	3630	Chemical	Gene	influence|nmod|START_ENTITY influence|nmod|secretion secretion|compound|END_ENTITY	The influence of indomethacin , theophylline , and propranolol on ethanol augmentation of glucose-induced insulin secretion .
6364813	0	indomethacin	51,63	insulin	30,37	indomethacin	insulin	MESH:D007213	105613195	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of glucose-induced insulin secretion by indomethacin and sodium_salicylate in the fetal lamb .
3257168	0	indomethacin	71,83	interleukin-1_alpha	48,67	indomethacin	interleukin-1 alpha	MESH:D007213	3552	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Augmented antitumor effect of recombinant human interleukin-1_alpha by indomethacin .
9420870	0	indomethacin	74,86	interleukin-1_alpha	24,43	indomethacin	interleukin-1 alpha	MESH:D007213	3552	Chemical	Gene	hydrocortisone|dep|START_ENTITY hydrocortisone|compound|END_ENTITY	Differential effects of interleukin-1_alpha , tumor_necrosis_factor-alpha , indomethacin , hydrocortisone , and macrophage co-culture on the proliferation of human fibroblasts and peritoneal mesothelial cells .
14991990	0	indomethacin	11,23	interleukin-6	41,54	indomethacin	interleukin-6	MESH:D007213	3569	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of indomethacin on expression of interleukin-6 caused by lipopolysaccharide in rheumatoid_arthritic patients ' synoviocyte -RSB- .
3263055	0	indomethacin	10,22	interleukin_1-alpha	64,83	indomethacin	interleukin 1-alpha	MESH:D007213	3552	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of indomethacin on febrile response to recombinant human interleukin_1-alpha in rabbits .
2887352	0	indomethacin	75,87	mucin	22,27	indomethacin	mucin	MESH:D007213	442975(Tax:9615)	Chemical	Gene	effect|nmod|START_ENTITY release|dep|effect release|nmod|END_ENTITY	Intestinal release of mucin in response to HCl and taurocholate : effect of indomethacin .
3975961	0	indomethacin	11,23	rCBF	27,31	indomethacin	rCBF	MESH:D007213	362686(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of indomethacin on rCBF during and after focal cerebral_ischemia in the cat .
1105696	0	indomethacin	14,26	renin	37,42	indomethacin	renin	MESH:D007213	5972	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|compound|END_ENTITY	The effect of indomethacin on plasma renin activity in man under normal conditions and after stimulation of the renin angiotensin system .
1756437	0	indomethacin	38,50	renin	81,86	indomethacin	renin	MESH:D007213	5972	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|concentration concentration|compound|END_ENTITY	Effect of prostaglandin inhibition by indomethacin on plasma active and inactive renin concentration in men .
3901121	0	indomethacin	10,22	renin	38,43	indomethacin	renin	MESH:D007213	24715(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|response response|compound|END_ENTITY	Effect of indomethacin on the adrenal renin response to nephrectomy in the rat .
522895	0	indomethacin	36,48	renin	115,120	indomethacin	renin	MESH:D007213	24715(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY Studies|nmod|effect Studies|nmod|increase increase|nmod|concentration concentration|compound|END_ENTITY	Studies on the inhibitory effect of indomethacin and meclofenamate on the adrenalectomy-induced increase in plasma renin concentration .
6183482	7	indomethacin	1033,1045	renin	1103,1108	indomethacin	renin	MESH:D007213	5972	Chemical	Gene	combination|nmod|START_ENTITY had|nsubj|combination had|nmod|activity activity|compound|END_ENTITY	The combination of indomethacin and aprotinin had a greater suppressive effect on plasma renin activity than indomethacin alone , suggesting a participation of kallikrein in renin release .
6183482	7	indomethacin	1123,1135	renin	1103,1108	indomethacin	renin	MESH:D007213	5972	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	The combination of indomethacin and aprotinin had a greater suppressive effect on plasma renin activity than indomethacin alone , suggesting a participation of kallikrein in renin release .
6425442	0	indomethacin	10,22	renin	46,51	indomethacin	renin	MESH:D007213	5972	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of indomethacin on active and inactive renin in sodium-replete men at rest and during exercise .
6430607	0	indomethacin	51,63	renin	34,39	indomethacin	renin	MESH:D007213	24715(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|Suppression Suppression|nmod|END_ENTITY	Suppression of bradykinin-induced renin release by indomethacin in anesthetized rats .
6986274	0	indomethacin	14,26	renin	51,56	indomethacin	renin	MESH:D007213	101081695	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|compound|END_ENTITY	The effect of indomethacin on isoprenaline-induced renin secretion in the cat .
6991156	0	indomethacin	11,23	renin	45,50	indomethacin	renin	MESH:D007213	403838(Tax:9615)	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	Effects of indomethacin and meclofenamate on renin release and renal hemodynamic function during chronic sodium depletion in conscious dogs .
6993088	0	indomethacin	43,55	renin	16,21	indomethacin	renin	MESH:D007213	24715(Tax:10116)	Chemical	Gene	blockade|nmod|START_ENTITY release|dep|blockade release|compound|END_ENTITY	Insulin-induced renin release : blockade by indomethacin in the rat .
7002082	0	indomethacin	51,63	renin	34,39	indomethacin	renin	MESH:D007213	24715(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of hydralazine-induced renin release by indomethacin in the rat .
7011052	0	indomethacin	11,23	renin	34,39	indomethacin	renin	MESH:D007213	24715(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|compound|END_ENTITY	Effects of indomethacin on plasma renin activity in the conscious rat .
7012436	0	indomethacin	10,22	renin	102,107	indomethacin	renin	MESH:D007213	24715(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|dependence dependence|nmod|activity activity|compound|END_ENTITY	Effect of indomethacin on blood pressure in rats with renovascular_hypertension : dependence on plasma renin activity .
7018734	0	indomethacin	11,23	renin	70,75	indomethacin	renin	MESH:D007213	403838(Tax:9615)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|compound|END_ENTITY	Effects of indomethacin , renal denervation , and propranolol on plasma renin activity in conscious dogs with chronic thoracic caval constriction .
7024992	0	indomethacin	11,23	renin	63,68	indomethacin	renin	MESH:D007213	403838(Tax:9615)	Chemical	Gene	Failure|nmod|START_ENTITY Failure|acl|inhibit inhibit|dobj|activity activity|compound|END_ENTITY	Failure of indomethacin to inhibit saralasin-stimulated plasma renin activity in conscious dogs with mild sodium depletion .
7048119	0	indomethacin	11,23	renin	27,32	indomethacin	renin	MESH:D007213	24715(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	-LSB- Effect of indomethacin on renin secretion in isolated perfused rat kidney -LRB- author 's transl -RRB- -RSB- .
756881	0	indomethacin	14,26	renin	37,42	indomethacin	renin	MESH:D007213	5972	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|compound|END_ENTITY	The effect of indomethacin on plasma renin activity and urinary aldosterone of patients with essential hypertension .
760897	0	indomethacin	131,143	renin	71,76	indomethacin	renin	MESH:D007213	24715(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|study study|nmod|action action|nmod|frusemide frusemide|nmod|END_ENTITY	A comparative study of the action of frusemide and methyclothiazide on renin release by rat kidney slices and the interaction with indomethacin .
821675	0	indomethacin	40,52	renin	22,27	indomethacin	renin	MESH:D007213	5972	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Suppression of plasma renin activity by indomethacin in man .
114569	0	indomethacin	85,97	thyrotropin_releasing_hormone	49,78	indomethacin	thyrotropin releasing hormone	MESH:D007213	7200	Chemical	Gene	treatment|compound|START_ENTITY END_ENTITY|nmod|treatment	Unchanged thyrotropin and prolactin responses to thyrotropin_releasing_hormone after indomethacin treatment .
10320804	0	indoxam	58,65	sPLA2	41,46	indoxam	sPLA2	MESH:C119389	18780(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Suppression of murine endotoxic shock by sPLA2 inhibitor , indoxam , through group IIA sPLA2-independent mechanisms .
24291743	0	indoxyl_3-sulfate	13,30	Th2	64,67	indoxyl 3-sulfate	Th2	null	15111(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Uremic toxin indoxyl_3-sulfate regulates the differentiation of Th2 but not of Th1 cells to lessen allergic_asthma .
24135442	0	indoxyl_sulfate	114,129	CYP3A5	66,72	indoxyl sulfate	CYP3A5	MESH:D007200	1577	Chemical	Gene	polymorphism|nmod|START_ENTITY polymorphism|compound|END_ENTITY	Association of plasma concentration of 4b-hydroxycholesterol with CYP3A5 polymorphism and plasma concentration of indoxyl_sulfate in stable kidney transplant recipients .
24051956	0	indoxyl_sulfate	15,30	fibroblast_growth_factor_23	36,63	indoxyl sulfate	fibroblast growth factor 23	MESH:D007200	8074	Chemical	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of indoxyl_sulfate with fibroblast_growth_factor_23 in patients with advanced chronic_kidney_disease .
20720180	0	indoxyl_sulfate	101,116	p53	83,86	indoxyl sulfate	p53	MESH:D007200	301300(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Senescence and dysfunction of proximal tubular cells are associated with activated p53 expression by indoxyl_sulfate .
11071964	0	indoxyl_sulphate	36,52	TGF-beta1	76,85	indoxyl sulphate	TGF-beta1	CHEBI:43355	59086(Tax:10116)	Chemical	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	An oral sorbent reduces overload of indoxyl_sulphate and gene expression of TGF-beta1 in uraemic rat kidneys .
8796119	0	inogatran	27,36	thrombin	78,86	inogatran	thrombin	MESH:C099871	100144442(Tax:9823)	Chemical	Gene	activity|nmod|START_ENTITY activity|appos|inhibitor inhibitor|nmod|END_ENTITY	Antithrombotic activity of inogatran , a new low-molecular-weight inhibitor of thrombin , in a closed-chest porcine model of coronary_artery_thrombosis .
8845466	0	inogatran	11,20	thrombin	49,57	inogatran	thrombin	MESH:C099871	29251(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|inhibitor inhibitor|compound|END_ENTITY	Effects of inogatran , a new low-molecular-weight thrombin inhibitor , in rat models of venous_and_arterial_thrombosis , thrombolysis and bleeding time .
9058487	0	inogatran	20,29	thrombin	64,72	inogatran	thrombin	MESH:C099871	2147	Chemical	Gene	effects|nmod|START_ENTITY inhibitor|nmod|effects inhibitor|nsubj|END_ENTITY	In vitro effects of inogatran , a selective low molecular weight thrombin inhibitor .
9510985	0	inogatran	27,36	thrombin	61,69	inogatran	thrombin	MESH:C099871	29251(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Animal pharmacokinetics of inogatran , a low-molecular-weight thrombin inhibitor with potential use as an antithrombotic drug .
9576150	0	inogatran	31,40	thrombin	65,73	inogatran	thrombin	MESH:C099871	2147	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Heparin is more effective than inogatran , a low-molecular weight thrombin inhibitor in suppressing ischemia and recurrent angina in unstable coronary disease .
11875050	0	inosine_monophosphate	17,38	IMPDH1	61,67	inosine monophosphate	IMPDH1	MESH:D007291	3614	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations in the inosine_monophosphate dehydrogenase 1 gene -LRB- IMPDH1 -RRB- cause the RP10 form of autosomal_dominant_retinitis_pigmentosa .
20718729	0	inosine_monophosphate	50,71	IMPDH1	87,93	inosine monophosphate	IMPDH1	MESH:D007291	3614	Chemical	Gene	Pharmacogenetics|nmod|START_ENTITY dehydrogenases|nsubj|Pharmacogenetics dehydrogenases|dobj|END_ENTITY	Pharmacogenetics of the mycophenolic_acid targets inosine_monophosphate dehydrogenases IMPDH1 and IMPDH2 : gene sequence variation and functional genomics .
17065099	0	inosine_monophosphate	64,85	TPMT	142,146	inosine monophosphate	TPMT	MESH:D007291	7172	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	HPLC/tandem ion trap mass detector methods for determination of inosine_monophosphate dehydrogenase -LRB- IMPDH -RRB- and thiopurine_methyltransferase -LRB- TPMT -RRB- .
16384889	0	inosine_triphosphate	27,47	ITPA	112,116	inosine triphosphate	ITPA	MESH:D007293	3704	Chemical	Gene	START_ENTITY|dobj|activity activity|nmod|genotype-phenotype genotype-phenotype|compound|END_ENTITY	Measurement of erythrocyte inosine_triphosphate pyrophosphohydrolase -LRB- ITPA -RRB- activity by HPLC and correlation of ITPA genotype-phenotype in a Caucasian population .
16384889	0	inosine_triphosphate	27,47	ITPA	70,74	inosine triphosphate	ITPA	MESH:D007293	3704	Chemical	Gene	START_ENTITY|dobj|activity activity|appos|END_ENTITY	Measurement of erythrocyte inosine_triphosphate pyrophosphohydrolase -LRB- ITPA -RRB- activity by HPLC and correlation of ITPA genotype-phenotype in a Caucasian population .
22009189	0	inosine_triphosphate	71,91	ITPA	109,113	inosine triphosphate	ITPA	MESH:D007293	3704	Chemical	Gene	variations|amod|START_ENTITY variations|appos|END_ENTITY	Epistatic interactions between thiopurine methyltransferase -LRB- TPMT -RRB- and inosine_triphosphate pyrophosphatase -LRB- ITPA -RRB- variations determine 6-mercaptopurine toxicity in Indian children with acute_lymphoblastic_leukemia .
22225964	0	inosine_triphosphate	20,40	ITPA	58,62	inosine triphosphate	ITPA	MESH:D007293	3704	Chemical	Gene	pyrophosphatase|amod|START_ENTITY pyrophosphatase|dep|END_ENTITY	Allele frequency of inosine_triphosphate pyrophosphatase -LRB- ITPA -RRB- and thiopurine-S-methyl_transferase -LRB- TPMT -RRB- genes in the Tunisian population .
23969025	0	inosine_triphosphate	6,26	ITPA	0,4	inosine triphosphate	ITPA	MESH:D007293	3704	Chemical	Gene	pyrophosphatase|amod|START_ENTITY END_ENTITY|appos|pyrophosphatase	ITPA -LRB- inosine_triphosphate pyrophosphatase -RRB- : from surveillance of nucleotide pools to human disease and pharmacogenetics .
8293297	0	inositol	30,38	CSF	26,29	inositol	CSF	MESH:D007294	1437	Chemical	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	Inositol treatment raises CSF inositol levels .
14608362	0	inositol	22,30	Cytochrome_c	0,12	inositol	Cytochrome c	MESH:D007294	54205	Chemical	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	Cytochrome_c binds to inositol -LRB- 1,4,5 -RRB- trisphosphate receptors , amplifying calcium-dependent apoptosis .
9027494	0	inositol	88,96	INPP5D	110,116	inositol	INPP5D	MESH:D007294	16331(Tax:10090)	Chemical	Gene	phosphatase|amod|START_ENTITY phosphatase|appos|END_ENTITY	Molecular cloning and chromosomal localization in human and mouse of the SH2-containing inositol phosphatase , INPP5D -LRB- SHIP -RRB- .
18056639	0	inositol	15,23	Ipk1	31,35	inositol	Ipk1	MESH:D007294	541511(Tax:7955)	Chemical	Gene	role|nmod|START_ENTITY kinase|nsubj|role kinase|dobj|END_ENTITY	A role for the inositol kinase Ipk1 in ciliary beating and length maintenance .
19019152	0	inositol	70,78	PIS1	57,61	inositol	PIS1	MESH:D007294	856229(Tax:4932)	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Transcription regulation of the Saccharomyces_cerevisiae PIS1 gene by inositol and the pleiotropic regulator , Ume6p .
22197784	0	inositol	50,58	SAS2203	96,103	inositol	SAS2203	MESH:D007294	2862177(Tax:282459)	Chemical	Gene	phosphatase|amod|START_ENTITY phosphatase|appos|END_ENTITY	Crystal structure of Staphylococcal dual specific inositol monophosphatase/NADP -LRB- H -RRB- phosphatase -LRB- SAS2203 -RRB- delineates the molecular basis of substrate specificity .
10207047	0	inositol	37,45	SHIP	58,62	inositol	SHIP	MESH:D007294	3635	Chemical	Gene	forms|amod|START_ENTITY forms|compound|END_ENTITY	The src homology domain 2-containing inositol phosphatase SHIP forms a ternary complex with Shc and Grb2 in antigen receptor-stimulated B lymphocytes .
12393695	0	inositol	15,23	SHIP-1	37,43	inositol	SHIP-1	MESH:D007294	3635	Chemical	Gene	phosphatase|amod|START_ENTITY phosphatase|appos|END_ENTITY	SH2-containing inositol phosphatase -LRB- SHIP-1 -RRB- transiently translocates to raft domains and modulates CD16-mediated cytotoxicity in human NK cells .
19494109	0	inositol	51,59	SHIP1	76,81	inositol	SHIP1	MESH:D007294	3635	Chemical	Gene	START_ENTITY|dobj|phosphatase phosphatase|appos|END_ENTITY	Regulation of the Src homology 2 domain-containing inositol 5 ' - phosphatase -LRB- SHIP1 -RRB- by the cyclic_AMP-dependent protein_kinase .
10789675	0	inositol	26,34	SHIP2	49,54	inositol	SHIP2	MESH:D007294	3636	Chemical	Gene	associates|amod|START_ENTITY associates|compound|END_ENTITY	The SH2 domain containing inositol 5-phosphatase SHIP2 associates to the immunoreceptor tyrosine-based inhibition motif of Fc_gammaRIIB in B cells under negative signaling .
9693122	0	inositol	49,57	insulin_receptor_substrate-1	14,42	inositol	insulin receptor substrate-1	MESH:D007294	3667	Chemical	Gene	START_ENTITY|nsubj|domain domain|nmod|binds binds|amod|END_ENTITY	PTB domain of insulin_receptor_substrate-1 binds inositol compounds .
2449164	0	inositol	22,30	myelin_basic_protein	41,61	inositol	myelin basic protein	MESH:D007294	618684(Tax:9913)	Chemical	Gene	measurement|nmod|START_ENTITY measurement|nmod|END_ENTITY	Direct measurement of inositol in bovine myelin_basic_protein .
2830908	0	inositol_bisphosphate	35,56	Prolactin	0,9	inositol bisphosphate	Prolactin	null	19109(Tax:10090)	Chemical	Gene	formation|nmod|START_ENTITY induces|dobj|formation induces|nsubj|END_ENTITY	Prolactin induces the formation of inositol_bisphosphate and inositol_trisphosphate in cultured mouse mammary gland explants .
3871404	0	inositol_bisphosphate	40,61	Thrombin	0,8	inositol bisphosphate	Thrombin	null	2147	Chemical	Gene	formation|nmod|START_ENTITY induces|dobj|formation induces|nsubj|END_ENTITY	Thrombin induces the rapid formation of inositol_bisphosphate and inositol_trisphosphate in human platelets .
18372961	0	inositol_hexaphosphate	21,43	Itpr3	57,62	inositol hexaphosphate	Itpr3	MESH:D010833	25679(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Apoptotic effects of inositol_hexaphosphate on biomarker Itpr3 in induced colon_rat_carcinogenesis .
17293967	0	inositol_hexaphosphate	62,84	TGF-beta2	48,57	inositol hexaphosphate	TGF-beta2	MESH:D010833	81809(Tax:10116)	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|appos|END_ENTITY	Modulation of transforming_growth_factor_beta2 -LRB- TGF-beta2 -RRB- by inositol_hexaphosphate in colon_carcinogenesis in rats .
21077672	0	inositol_hexaphosphate	104,126	fibroblast_growth_factor	48,72	inositol hexaphosphate	fibroblast growth factor	MESH:D010833	2246	Chemical	Gene	START_ENTITY|nsubj|interaction interaction|nmod|END_ENTITY	Molecular level interaction of the human acidic fibroblast_growth_factor with the antiangiogenic agent , inositol_hexaphosphate .
1194291	0	inositol_hexaphosphate	13,35	methemoglobin	71,84	inositol hexaphosphate	methemoglobin	MESH:D010833	3048	Chemical	Gene	Influence|nmod|START_ENTITY binding|nsubj|Influence binding|nmod|END_ENTITY	Influence of inositol_hexaphosphate binding on subunit dissociation in methemoglobin .
1393	0	inositol_hexaphosphate	11,33	methemoglobin	43,56	inositol hexaphosphate	methemoglobin	MESH:D010833	3048	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of inositol_hexaphosphate to human methemoglobin .
2548610	0	inositol_hexaphosphate	52,74	methemoglobin	26,39	inositol hexaphosphate	methemoglobin	MESH:D010833	3048	Chemical	Gene	spectroscopy|compound|START_ENTITY effects|nmod|spectroscopy equilibrium|dep|effects equilibrium|nmod|END_ENTITY	Spin equilibrium in human methemoglobin : effects of inositol_hexaphosphate and bezafibrate as measured by resonance Raman spectroscopy .
7451474	0	inositol_hexaphosphate	34,56	methemoglobin	15,28	inositol hexaphosphate	methemoglobin	MESH:D010833	3048	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of methemoglobin with inositol_hexaphosphate .
22475172	0	inositol_hexaphosphate	31,53	synaptotagmin_I	83,98	inositol hexaphosphate	synaptotagmin I	MESH:D010833	6857	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Molecular level interaction of inositol_hexaphosphate with the C2B domain of human synaptotagmin_I .
17293967	0	inositol_hexaphosphate	62,84	transforming_growth_factor_beta2	14,46	inositol hexaphosphate	transforming growth factor beta2	MESH:D010833	81809(Tax:10116)	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|END_ENTITY	Modulation of transforming_growth_factor_beta2 -LRB- TGF-beta2 -RRB- by inositol_hexaphosphate in colon_carcinogenesis in rats .
2546960	0	inositol_phosphate	31,49	Angiotensin_II	0,14	inositol phosphate	Angiotensin II	CHEBI:24846	183	Chemical	Gene	production|amod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates both inositol_phosphate production and human placental lactogen release from human trophoblastic cells .
3090472	0	inositol_phosphate	26,44	Angiotensin_II	0,14	inositol phosphate	Angiotensin II	CHEBI:24846	24179(Tax:10116)	Chemical	Gene	formation|amod|START_ENTITY stimulates|dobj|formation stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates inositol_phosphate formation in rat anterior pituitary glands .
11030616	0	inositol_phosphate	11,29	DNA-PK	33,39	inositol phosphate	DNA-PK	CHEBI:24846	5591	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of inositol_phosphate to DNA-PK and stimulation of double-strand break repair .
1744468	0	inositol_phosphate	21,39	Endothelin-1	0,12	inositol phosphate	Endothelin-1	CHEBI:24846	24323(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Endothelin-1 induces inositol_phosphate production in rat pregnant myometrium .
8645468	0	inositol_phosphate	27,45	Interferon-gamma	0,16	inositol phosphate	Interferon-gamma	CHEBI:24846	3458	Chemical	Gene	START_ENTITY|nsubj|increases increases|amod|END_ENTITY	Interferon-gamma increases inositol_phosphate formation and cellular calcium ion concentration independent of ICAM-1 antigen enhancement in renal tubular cells .
3277859	0	inositol_phosphate	48,66	N-ras	79,84	inositol phosphate	N-ras	CHEBI:24846	4893	Chemical	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	Inhibition of the amplified bombesin-stimulated inositol_phosphate response in N-ras transformed cells by high density culturing .
15063008	0	inositol_phosphate	65,83	NPY	31,34	inositol phosphate	NPY	CHEBI:24846	504216(Tax:9913)	Chemical	Gene	formation|compound|START_ENTITY enhancement|nmod|formation enhancement|compound|END_ENTITY	Betagamma subunits mediate the NPY enhancement of ATP-stimulated inositol_phosphate formation .
8243300	0	inositol_phosphate	117,135	PKC	182,185	inositol phosphate	PKC	CHEBI:24846	112476	Chemical	Gene	production|compound|START_ENTITY production|appos|END_ENTITY	Cholera toxin and dibutyryl_cyclic_adenosine_3 ' ,5 ' - monophosphate sensitize gonadotropin-releasing_hormone-stimulated inositol_phosphate production to inhibition in protein_kinase-C -LRB- PKC -RRB- - depleted cells : evidence for cross-talk between a cholera_toxin-sensitive G-protein and PKC .
11294858	0	inositol_phosphate	73,91	Regulator_of_G-protein_signaling_3	0,34	inositol phosphate	Regulator of G-protein signaling 3	CHEBI:24846	5998	Chemical	Gene	production|compound|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Regulator_of_G-protein_signaling_3 -LRB- RGS3 -RRB- inhibits Gbeta1gamma 2-induced inositol_phosphate production , mitogen-activated protein kinase activation , and Akt activation .
1486937	0	inositol_phosphate	20,38	Thrombin	0,8	inositol phosphate	Thrombin	CHEBI:24846	2147	Chemical	Gene	fluxes|amod|START_ENTITY stimulates|dobj|fluxes stimulates|nsubj|END_ENTITY	Thrombin stimulates inositol_phosphate formation , intracellular calcium fluxes and DNA synthesis in cultured fetal human non-pigmented ciliary epithelial cells .
1800126	0	inositol_phosphate	64,82	Thrombin	0,8	inositol phosphate	Thrombin	CHEBI:24846	2147	Chemical	Gene	coupled|xcomp|START_ENTITY coupled|nsubjpass|END_ENTITY	Thrombin signalling in U937 human monocytic cells is coupled to inositol_phosphate formation but not to thromboxane_B2 synthesis nor to inhibition of adenylate cyclase : distinct differences in thrombin signalling between U937 cells and platelets .
2153536	0	inositol_phosphate	20,38	Thrombin	0,8	inositol phosphate	Thrombin	CHEBI:24846	29251(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|stimulates stimulates|compound|END_ENTITY	Thrombin stimulates inositol_phosphate production and intracellular free calcium by a pertussis toxin-insensitive mechanism in osteosarcoma cells .
2665165	0	inositol_phosphate	20,38	Thrombin	0,8	inositol phosphate	Thrombin	CHEBI:24846	2147	Chemical	Gene	accumulation|amod|START_ENTITY stimulates|dobj|accumulation stimulates|nsubj|END_ENTITY	Thrombin stimulates inositol_phosphate accumulation and prostacyclin synthesis in human endothelial cells from umbilical vein but not from omentum .
3280722	0	inositol_phosphate	103,121	angiotensin_II	14,28	inositol phosphate	angiotensin II	CHEBI:24846	24179(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY mediating|dobj|production agent|acl|mediating agent|nsubj|END_ENTITY	Evidence that angiotensin_II is a paracrine agent mediating gonadotrophin-releasing_hormone-stimulated inositol_phosphate production and prolactin secretion in the rat .
3359576	0	inositol_phosphate	111,129	angiotensin_II	50,64	inositol phosphate	angiotensin II	CHEBI:24846	183	Chemical	Gene	production|amod|START_ENTITY coupling|nmod|production Identification|dep|coupling Identification|acl|guinea_pig guinea_pig|dobj|ventricular ventricular|amod|END_ENTITY	Identification and characterization of guinea_pig angiotensin_II ventricular and atrial receptors : coupling to inositol_phosphate production .
1316547	0	inositol_phosphate	105,123	calcitonin_receptor	14,33	inositol phosphate	calcitonin receptor	CHEBI:24846	799	Chemical	Gene	stimulates|dobj|START_ENTITY stimulates|nsubj|END_ENTITY	A recombinant calcitonin_receptor independently stimulates 3 ' ,5 ' - cyclic_adenosine_monophosphate and Ca2 + / inositol_phosphate signaling pathways .
1984783	0	inositol_phosphate	42,60	epidermal_growth_factor	15,38	inositol phosphate	epidermal growth factor	CHEBI:24846	1950	Chemical	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	Stimulation by epidermal_growth_factor of inositol_phosphate production in plasma membranes from A431 cells .
3040912	0	inositol_phosphate	15,33	neurotensin	48,59	inositol phosphate	neurotensin	CHEBI:24846	67405(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Stimulation of inositol_phosphate production by neurotensin in neuroblastoma N1E115 cells : implication of GTP-binding proteins and relationship with the cyclic_GMP response .
1800126	0	inositol_phosphate	64,82	thrombin	193,201	inositol phosphate	thrombin	CHEBI:24846	2147	Chemical	Gene	START_ENTITY|dobj|differences differences|nmod|END_ENTITY	Thrombin signalling in U937 human monocytic cells is coupled to inositol_phosphate formation but not to thromboxane_B2 synthesis nor to inhibition of adenylate cyclase : distinct differences in thrombin signalling between U937 cells and platelets .
2494171	0	inositol_phosphate	107,125	thrombin	54,62	inositol phosphate	thrombin	CHEBI:24846	2147	Chemical	Gene	release|compound|START_ENTITY release|amod|END_ENTITY	Guanosine_5 ' - O - -LRB- 3-thiotrisphosphate -RRB- potentiates both thrombin - and platelet-derived growth factor-induced inositol_phosphate release in permeabilized vascular smooth muscle cells .
3091078	0	inositol_phosphate	49,67	thrombin	140,148	inositol phosphate	thrombin	CHEBI:24846	2147	Chemical	Gene	formation|amod|START_ENTITY END_ENTITY|nsubj|formation	Differential effects of spermine on aggregation , inositol_phosphate formation and protein phosphorylation in human platelets in response to thrombin , arachidonic_acid and lysophosphatidic_acid .
3770193	0	inositol_phosphate	18,36	thrombin	80,88	inositol phosphate	thrombin	CHEBI:24846	2147	Chemical	Gene	formation|amod|START_ENTITY inhibits|dobj|formation inhibits|nmod|platelets platelets|acl|stimulated stimulated|nmod|END_ENTITY	Neomycin inhibits inositol_phosphate formation in human platelets stimulated by thrombin but not other agonists .
8566174	0	inositol_phosphate	4,22	thrombin	35,43	inositol phosphate	thrombin	CHEBI:24846	29251(Tax:10116)	Chemical	Gene	response|amod|START_ENTITY response|acl|END_ENTITY	The inositol_phosphate response to thrombin in rat right atria differs from the response to noradrenaline .
15297462	0	inositol_phosphates	48,67	CK2	31,34	inositol phosphates	CK2	MESH:D007295	81650(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|appos|END_ENTITY	Regulation of casein kinase-2 -LRB- CK2 -RRB- activity by inositol_phosphates .
3663137	0	inositol_phosphates	11,30	Ca2	48,51	inositol phosphates	Ca2	MESH:D007295	280740(Tax:9913)	Chemical	Gene	START_ENTITY|nmod|+ +|amod|END_ENTITY	Binding of inositol_phosphates and induction of Ca2 + release from pituitary microsomal fractions .
24749013	0	inositol_phosphates	49,68	Fibrinogen	0,10	inositol phosphates	Fibrinogen	MESH:D007295	2244	Chemical	Gene	target|nmod|START_ENTITY END_ENTITY|dep|target	Fibrinogen - a possible extracellular target for inositol_phosphates .
3800950	0	inositol_phosphates	54,73	enkephalin	106,116	inositol phosphates	enkephalin	MESH:D007295	29237(Tax:10116)	Chemical	Gene	Changes|nmod|START_ENTITY Changes|nmod|END_ENTITY	Changes in free cytosolic calcium and accumulation of inositol_phosphates in isolated hepatocytes by -LSB- Leu -RSB- enkephalin .
6098333	0	inositol_phospholipid	23,44	Neurotensin	0,11	inositol phospholipid	Neurotensin	null	299757(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|stimulates stimulates|compound|END_ENTITY	Neurotensin stimulates inositol_phospholipid hydrolysis in rat brain slices .
20624911	0	inositol_polyphosphate	22,44	Asp1	0,4	inositol polyphosphate	Asp1	null	851920(Tax:4932)	Chemical	Gene	kinase|compound|START_ENTITY END_ENTITY|appos|kinase	Asp1 , a conserved 1/3 inositol_polyphosphate kinase , regulates the dimorphic switch in Schizosaccharomyces_pombe .
15618435	0	inositol_polyphosphate	22,44	AtIPK2alpha	53,64	inositol polyphosphate	AtIPK2alpha	null	830628(Tax:3702)	Chemical	Gene	START_ENTITY|dobj|kinase kinase|appos|END_ENTITY	A role of Arabidopsis inositol_polyphosphate kinase , AtIPK2alpha , in pollen germination and root growth .
3771575	0	inositol_polyphosphate	26,48	Bradykinin	0,10	inositol polyphosphate	Bradykinin	null	3827	Chemical	Gene	production|amod|START_ENTITY stimulation|nmod|production stimulation|compound|END_ENTITY	Bradykinin stimulation of inositol_polyphosphate production in porcine aortic endothelial cells .
11956213	0	inositol_polyphosphate	33,55	Kcs1p	75,80	inositol polyphosphate	Kcs1p	null	851580(Tax:4932)	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	In Saccharomyces_cerevisiae , the inositol_polyphosphate kinase activity of Kcs1p is required for resistance to salt stress , cell wall integrity , and vacuolar morphogenesis .
15353600	0	inositol_polyphosphate	4,26	Ocrl	41,45	inositol polyphosphate	Ocrl	null	4952	Chemical	Gene	associates|amod|START_ENTITY associates|compound|END_ENTITY	The inositol_polyphosphate 5-phosphatase Ocrl associates with endosomes that are partially coated with clathrin .
3263806	0	inositol_polyphosphates	13,36	PTH	0,3	inositol polyphosphates	PTH	null	24694(Tax:10116)	Chemical	Gene	elevates|dobj|START_ENTITY elevates|nsubj|END_ENTITY	PTH elevates inositol_polyphosphates and diacylglycerol in a rat osteoblast-like cell line .
20226542	0	inositol_triphosphate	39,60	ITPR1	71,76	inositol triphosphate	ITPR1	null	3708	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Human ataxias : a genetic dissection of inositol_triphosphate receptor -LRB- ITPR1 -RRB- - dependent signaling .
23859941	0	inositol_triphosphate	63,84	Itpr3	52,57	inositol triphosphate	Itpr3	null	16440(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY END_ENTITY|appos|receptor	Taste dysfunction in BTBR mice due to a mutation of Itpr3 , the inositol_triphosphate receptor 3 gene .
6092355	0	inositol_trisphosphate	14,36	Ca2	40,43	inositol trisphosphate	Ca2	null	54231(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|+ +|amod|END_ENTITY	The effect of inositol_trisphosphate on Ca2 + fluxes in insulin-secreting tumor cells .
10775502	0	inositol_trisphosphate	27,49	IL-1_beta	0,9	inositol trisphosphate	IL-1 beta	null	16176(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|increases increases|amod|END_ENTITY	IL-1_beta increases type 1 inositol_trisphosphate receptor expression and IL-6 secretory capacity in osteoblastic cell cultures .
16274363	0	inositol_trisphosphate	15,37	IP3R	48,52	inositol trisphosphate	IP3R	null	25262(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Agonist-evoked inositol_trisphosphate receptor -LRB- IP3R -RRB- clustering is not dependent on changes in the structure of the endoplasmic reticulum .
1381021	0	inositol_trisphosphate	40,62	endothelin-1	73,85	inositol trisphosphate	endothelin-1	null	1906	Chemical	Gene	START_ENTITY|acl|evoked evoked|nmod|cells cells|amod|END_ENTITY	Dexamethasone potentiates production of inositol_trisphosphate evoked by endothelin-1 in vascular smooth muscle cells .
3025260	0	inositol_trisphosphate	15,37	parathyroid_hormone	94,113	inositol trisphosphate	parathyroid hormone	null	5741	Chemical	Gene	production|amod|START_ENTITY Stimulation|nmod|production Stimulation|nmod|END_ENTITY	Stimulation of inositol_trisphosphate and diacylglycerol production in renal tubular cells by parathyroid_hormone .
10326889	0	intrauterine	14,26	sex_hormone-binding_globulin	93,121	intrauterine	sex hormone-binding globulin	null	6462	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of intrauterine and oral levonorgestrel administration on serum concentrations of sex_hormone-binding_globulin , insulin and insulin-like_growth_factor_binding_protein-1 .
23283814	0	involucrin	14,24	ERK1/2	76,82	involucrin	ERK1/2	null	5595;5594	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|dep|roles roles|nmod|END_ENTITY	Regulation of involucrin in psoriatic epidermal keratinocytes : the roles of ERK1/2 and GSK-3b .
12047906	0	iodide	36,42	Atrial_natriuretic_peptide	0,26	iodide	Atrial natriuretic peptide	CHEBI:16382	281355(Tax:9913)	Chemical	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Atrial_natriuretic_peptide inhibits iodide uptake and thyroglobulin messenger ribonucleic acid expression in cultured bovine thyroid follicles .
24231001	0	iodide	42,48	IRE1	16,20	iodide	IRE1	CHEBI:16382	2081	Chemical	Gene	pathway|nmod|START_ENTITY pathway|compound|END_ENTITY	The role of the IRE1 pathway in excessive iodide - and/or fluoride-induced apoptosis in Nthy-ori 3-1 cells in vitro .
24708099	0	iodide	13,19	NIS	0,3	iodide	NIS	CHEBI:16382	6528	Chemical	Gene	uptake|amod|START_ENTITY mediates|dobj|uptake mediates|nsubj|END_ENTITY	NIS mediates iodide uptake in the female reproductive tract and is a poor prognostic factor in ovarian_cancer .
10782045	0	iodide	25,31	Prolactin	0,9	iodide	Prolactin	CHEBI:16382	19109(Tax:10090)	Chemical	Gene	uptake|amod|START_ENTITY stimulation|nmod|uptake stimulation|compound|END_ENTITY	Prolactin stimulation of iodide uptake and incorporation into protein is polyamine-dependent in mouse mammary gland explants .
16514173	0	iodide	33,39	Sodium-iodide_symporter	0,23	iodide	Sodium-iodide symporter	CHEBI:16382	114613(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY mediates|dobj|secretion mediates|nsubj|END_ENTITY	Sodium-iodide_symporter mediates iodide secretion in rat gastric mucosa in vitro .
25298423	0	iodide	40,46	TMEM16A	12,19	iodide	TMEM16A	CHEBI:16382	309135(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY channel|nsubj|END_ENTITY	Anoctamin-1 / TMEM16A is the major apical iodide channel of the thyrocyte .
25328990	0	iodide	75,81	TPO	13,16	iodide	TPO	CHEBI:16382	7173	Chemical	Gene	START_ENTITY|nsubj|mutation mutation|compound|END_ENTITY	A truncating TPO mutation -LRB- Y55X -RRB- in patients with hypothyroidism and total iodide organification defect .
7925105	0	iodide	75,81	epidermal_growth_factor	11,34	iodide	epidermal growth factor	CHEBI:16382	1950	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of epidermal_growth_factor on basolateral iodide uptake and apical iodide permeability in filter-cultured thyroid epithelium .
19768779	0	iodide	78,84	lactoperoxidase	14,29	iodide	lactoperoxidase	CHEBI:16382	4025	Chemical	Gene	START_ENTITY|nsubj|Activation Activation|nmod|END_ENTITY	Activation of lactoperoxidase by heme-linked protonation and heme-independent iodide binding .
9270719	0	iodide	48,54	prolactin	23,32	iodide	prolactin	CHEBI:16382	5617	Chemical	Gene	stimulation|nmod|START_ENTITY stimulation|compound|END_ENTITY	Characteristics of the prolactin stimulation of iodide uptake into mouse mammary gland explants .
1212981	0	iodide	14,20	thyroglobulin	80,93	iodide	thyroglobulin	CHEBI:16382	7038	Chemical	Gene	administration|amod|START_ENTITY effect|nmod|administration effect|nmod|END_ENTITY	The effect of iodide administration on hog thyroid gland and the composition of thyroglobulin and 27-S iodoprotein .
17933915	0	iodine	38,44	C-21	90,94	iodine	C-21	MESH:D007455	79718	Chemical	Gene	uptake|nmod|START_ENTITY uptake|nmod|END_ENTITY	Hydrogen_peroxide-dependent uptake of iodine by marine Flavobacteriaceae bacterium strain C-21 .
18788581	0	iodine	13,19	CCK	37,40	iodine	CCK	MESH:D007455	25298(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Overdose of iodine on expression of CCK gene in rat brains -RSB- .
21968267	0	iodine	33,39	CXCL-10	51,58	iodine	CXCL-10	MESH:D007455	3627	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Short-term effect of radioactive iodine therapy on CXCL-10 production in Graves ' _ disease .
2922938	0	iodine	22,28	Milk	0,4	iodine	Milk	MESH:D007455	100532204	Chemical	Gene	status|amod|START_ENTITY analysis|nmod|status analysis|compound|END_ENTITY	Milk analysis for the iodine status of dairy cows .
3700786	0	iodine	5,11	Milk	0,4	iodine	Milk	MESH:D007455	100532204	Chemical	Gene	residues|compound|START_ENTITY residues|compound|END_ENTITY	Milk iodine residues in herds practicing iodophor premilking teat disinfection .
821840	0	iodine	10,16	TRH	26,29	iodine	TRH	MESH:D007455	7200	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|release release|compound|END_ENTITY	Effect of iodine upon the TRH induced release of TSH in euthyroid , hypothyroid and hyperthyroid individuals .
21801606	0	iodine	63,69	Telomerase_reverse_transcriptase	0,32	iodine	Telomerase reverse transcriptase	MESH:D007455	7015	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Telomerase_reverse_transcriptase promoter-driven expression of iodine pump genes for targeted radioiodine therapy of malignant_glioma cells .
463037	0	iodine	38,44	fibrinogen	45,55	iodine	fibrinogen	MESH:D007455	2244	Chemical	Gene	test|amod|START_ENTITY test|compound|END_ENTITY	-LSB- Differences in the evaluation of the iodine fibrinogen test -LRB- author 's transl -RRB- -RSB- .
6910459	0	iodine	98,104	fibrinogen	105,115	iodine	fibrinogen	MESH:D007455	2244	Chemical	Gene	test|amod|START_ENTITY test|compound|END_ENTITY	-LSB- Monitoring of post-operative prevention of thrombosis by low dosage heparin with the radioactive iodine fibrinogen test -LRB- author 's transl -RRB- -RSB- .
11305779	0	iodine	11,17	inducible_nitric_oxide_synthase	21,52	iodine	inducible nitric oxide synthase	MESH:D007455	4843	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|amod|END_ENTITY	Effects of iodine on inducible_nitric_oxide_synthase and cyclooxygenase-2 expression in sulfur mustard-induced skin .
23203253	0	iodine	8,14	insulin	34,41	iodine	insulin	MESH:D007455	3630	Chemical	Gene	associated|nsubjpass|START_ENTITY associated|nmod|resistance resistance|compound|END_ENTITY	Urinary iodine is associated with insulin resistance in subjects with diabetes_mellitus type 2 .
15641262	0	iodine	13,19	insulin-like_growth_factor-I	45,73	iodine	insulin-like growth factor-I	MESH:D007455	3479	Chemical	Gene	supplementation|amod|START_ENTITY supplementation|nmod|END_ENTITY	Influence of iodine supplementation on serum insulin-like_growth_factor-I -LRB- IGF-I -RRB- and IGF-binding_protein-3 -LRB- IGFBP-3 -RRB- levels in severe_iodine_deficiency .
18059417	0	iodine	22,28	milk	68,72	iodine	milk	MESH:D007455	100532204	Chemical	Gene	Evaluation|nmod|START_ENTITY excretion|nsubj|Evaluation excretion|nmod|biomarker biomarker|nmod|intake intake|nmod|products products|compound|END_ENTITY	Evaluation of urinary iodine excretion as a biomarker for intake of milk and dairy products in pregnant women in the Norwegian Mother and Child Cohort Study -LRB- MoBa -RRB- .
25300111	0	iodine	85,91	milk	37,41	iodine	milk	MESH:D007455	100532204	Chemical	Gene	-RSB-|amod|START_ENTITY improve|nmod|-RSB- Effectiveness|acl|improve Effectiveness|nmod|use use|nmod|protein protein|compound|END_ENTITY	-LSB- Effectiveness of the use of iodized milk protein to improve girls ' sufficiency with iodine -RSB- .
21737629	0	iodine	84,90	thyroglobulin	12,25	iodine	thyroglobulin	MESH:D007455	7038	Chemical	Gene	therapy|nmod|START_ENTITY END_ENTITY|nmod|therapy	Response of thyroglobulin to radioiodine therapy in thyroglobulin-elevated negative iodine scintigraphy -LRB- TENIS -RRB- syndrome .
7664637	0	iodine	88,94	thyroglobulin	106,119	iodine	thyroglobulin	MESH:D007455	24826(Tax:10116)	Chemical	Gene	content|amod|START_ENTITY content|nmod|END_ENTITY	On the relationship between completion of N-acetyllactosamine oligosaccharide units and iodine content of thyroglobulin : a reinvestigation .
16141710	0	iodine-123_metaiodobenzylguanidine	23,57	myeloperoxidase	75,90	iodine-123 metaiodobenzylguanidine	myeloperoxidase	null	4353	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	Reduced lung uptake of iodine-123_metaiodobenzylguanidine in patients with myeloperoxidase antineutrophil cytoplasmic antibodies-positive vasculitis .
9363985	0	iodoacetamide	26,39	protein_kinase_C_alpha	67,89	iodoacetamide	protein kinase C alpha	MESH:D007460	397184(Tax:9823)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|degradation degradation|nmod|END_ENTITY	The ATP-depleting reagent iodoacetamide induces the degradation of protein_kinase_C_alpha -LRB- PKC alpha -RRB- in LLC-PK1 pig kidney cells .
6952939	0	iodoacetic_acid	45,60	thiosulfate_sulfurtransferase	75,104	iodoacetic acid	thiosulfate sulfurtransferase	MESH:D019807	7263	Chemical	Gene	specificity|nmod|START_ENTITY specificity|nmod|END_ENTITY	The specificity of active-site alkylation by iodoacetic_acid in the enzyme thiosulfate_sulfurtransferase .
3983096	0	iodoamino_acid	53,67	thyroglobulin	83,96	iodoamino acid	thyroglobulin	CHEBI:24862	7038	Chemical	Gene	composition|amod|START_ENTITY composition|nmod|END_ENTITY	-LSB- Effect of cryopreservation of thyroid parenchyma on iodoamino_acid composition of thyroglobulin and its iodination -RSB- .
9252419	0	iodomycin	20,29	P-glycoprotein	54,68	iodomycin	P-glycoprotein	MESH:C060588	5243	Chemical	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Localization of the iodomycin binding site in hamster P-glycoprotein .
6299186	0	iodopenicillanate	38,55	beta-Lactamase	0,14	iodopenicillanate	beta-Lactamase	null	7872529(Tax:562)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	beta-Lactamase inhibitory activity of iodopenicillanate and bromopenicillanate .
20962050	4	iodoresiniferatoxin	881,900	vanilloid	902,911	iodoresiniferatoxin	caspase-9	MESH:C468130	842	Chemical	Gene	antagonist|amod|START_ENTITY antagonist|amod|END_ENTITY	The effect of Met-AEA -LRB- 1 m -RRB- was prevented by SR141716 , CB -LRB- 1 -RRB- cannabinoid receptor antagonist , but not by SR144528 , CB -LRB- 2 -RRB- antagonist , nor by iodoresiniferatoxin , vanilloid receptor antagonist .
18426912	0	iodothyronine	115,128	GATA4	150,155	iodothyronine	GATA4	CHEBI:24864	14463(Tax:10090)	Chemical	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Hepatocyte nuclear factor 4alpha contributes to thyroid hormone homeostasis by cooperatively regulating the type 1 iodothyronine deiodinase gene with GATA4 and Kruppel-like transcription factor 9 .
8964838	0	iodothyronine	65,78	dio1	91,95	iodothyronine	dio1	CHEBI:24864	1733	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The structure of the coding and 5 ' - flanking region of the type 1 iodothyronine deiodinase -LRB- dio1 -RRB- gene is normal in a patient with suspected congenital_dio1_deficiency .
11861502	0	iodothyronine	20,33	sulfatase	34,43	iodothyronine	sulfatase	CHEBI:24864	347527	Chemical	Gene	activities|amod|START_ENTITY activities|compound|END_ENTITY	Characterization of iodothyronine sulfatase activities in human and rat liver and placenta .
1009934	0	iodotyrosine	31,43	thyroglobulin	56,69	iodotyrosine	thyroglobulin	MESH:D007470	7038	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	Maximal number of hormonogenic iodotyrosine residues in thyroglobulin iodinated by thyroid peroxidase .
21068719	0	iomazenil	53,62	GABA_receptor	8,21	iomazenil	GABA receptor	MESH:C063038	11337	Chemical	Gene	function|nmod|START_ENTITY function|nsubj|END_ENTITY	Probing GABA_receptor function in schizophrenia with iomazenil .
3933179	0	ionol	11,16	cytochrome_P-450	20,36	ionol	cytochrome P-450	MESH:D002084	25251(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|induction induction|amod|END_ENTITY	-LSB- Effect of ionol on cytochrome_P-450 induction in the liver of rats by polychlorinated_biphenyls -RSB- .
3160693	0	ionomycin	93,102	thyrotropin-releasing_hormone	112,141	ionomycin	thyrotropin-releasing hormone	MESH:D015759	25569(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|responses responses|amod|END_ENTITY	Dual actions of phorbol_esters on cytosolic free Ca2 + concentrations and reconstitution with ionomycin of acute thyrotropin-releasing_hormone responses .
11294523	0	iopromide	26,35	thrombin	14,22	iopromide	thrombin	MESH:C038192	2147	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of thrombin by iopromide in vitro .
17553549	0	ioxinyl	80,87	transthyretin	63,76	ioxinyl	transthyretin	null	7276	Chemical	Gene	binding|nmod|START_ENTITY binding|nmod|END_ENTITY	Disruption of thyroid hormone binding to sea bream recombinant transthyretin by ioxinyl and polybrominated_diphenyl_ethers .
22139434	0	ipragliflozin	27,40	SGLT2	70,75	ipragliflozin	SGLT2	MESH:C572941	246787(Tax:10090)	Chemical	Gene	profile|nmod|START_ENTITY profile|appos|inhibitor inhibitor|compound|END_ENTITY	Pharmacological profile of ipragliflozin -LRB- ASP1941 -RRB- , a novel selective SGLT2 inhibitor , in vitro and in vivo .
23733389	0	ipragliflozin	69,82	SGLT2	125,130	ipragliflozin	SGLT2	MESH:C572941	6524	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	The effect of moderate hepatic_impairment on the pharmacokinetics of ipragliflozin , a novel sodium_glucose co-transporter 2 -LRB- SGLT2 -RRB- inhibitor .
26829386	0	ipragliflozin	10,23	SGLT2	28,33	ipragliflozin	SGLT2	MESH:C572941	64522(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Effect of ipragliflozin , an SGLT2 inhibitor , on progression of diabetic_microvascular_complications in spontaneously diabetic Torii fatty rats .
12195603	0	ipratropium	40,51	COPD	69,73	ipratropium	COPD	MESH:D009241	260431	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	Tiotropium : a potential replacement for ipratropium in patients with COPD .
12645834	0	ipratropium	41,52	COPD	84,88	ipratropium	COPD	MESH:D009241	260431	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	Is there any association between inhaled ipratropium and mortality in patients with COPD and asthma ?
2943994	0	ipratropium_bromide	115,134	beta-2	49,55	ipratropium bromide	beta-2	MESH:D009241	10242	Chemical	Gene	agent|appos|START_ENTITY agent|amod|END_ENTITY	A comparison of the bronchodilating effects of a beta-2 adrenergic agent -LRB- albuterol -RRB- and an anticholinergic agent -LRB- ipratropium_bromide -RRB- , given by aerosol alone or in sequence .
9005368	0	ipriflavone	12,23	GnRH	48,52	ipriflavone	GnRH	MESH:C018986	2796	Chemical	Gene	Effects|nmod|START_ENTITY induced|nsubj|Effects induced|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Effects of ipriflavone on bone_loss induced by GnRH analog -RSB- .
2547306	0	iproplatin	18,28	CHIP	30,34	iproplatin	CHIP	MESH:C023359	358	Chemical	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Phase II study of iproplatin -LRB- CHIP -RRB- in previously treated small-cell_lung_cancer .
2705402	0	iproplatin	20,30	CHIP	32,36	iproplatin	CHIP	MESH:C023359	358	Chemical	Gene	trial|nmod|START_ENTITY trial|appos|END_ENTITY	A phase II trial of iproplatin -LRB- CHIP -RRB- in previously treated advanced_breast_cancer .
3189231	0	iproplatin	18,28	CHIP	30,34	iproplatin	CHIP	MESH:C023359	358	Chemical	Gene	trial|nmod|START_ENTITY trial|appos|END_ENTITY	Phase II trial of iproplatin -LRB- CHIP -RRB- in previously untreated patients with colorectal_cancer .
11281940	0	ipsapirone	17,27	5-HT-1A	110,117	ipsapirone	5-HT-1A	MESH:C043077	3350	Chemical	Gene	Effectiveness|nmod|START_ENTITY Effectiveness|dep|support support|nmod|role role|nmod|receptors receptors|nummod|END_ENTITY	Effectiveness of ipsapirone , a 5-HT-1A partial agonist , in major_depressive_disorder : support for the role of 5-HT-1A receptors in the mechanism of action of serotonergic antidepressants .
11281940	0	ipsapirone	17,27	5-HT-1A	31,38	ipsapirone	5-HT-1A	MESH:C043077	3350	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Effectiveness of ipsapirone , a 5-HT-1A partial agonist , in major_depressive_disorder : support for the role of 5-HT-1A receptors in the mechanism of action of serotonergic antidepressants .
10607079	0	ipsapirone	11,21	5-HT1A	25,31	ipsapirone	5-HT1A	MESH:C043077	24473(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Effects of ipsapirone , a 5-HT1A agonist , on sleep/wakefulness cycles : probable post-synaptic action .
1354556	0	ipsapirone	55,65	5-HT1A	69,75	ipsapirone	5-HT1A	MESH:C043077	24473(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Comparison_of_neuroendocrine and behavioral effects of ipsapirone , a 5-HT1A agonist , in three stress paradigms : immobilization , forced swim and conditioned fear .
1679740	0	ipsapirone	94,104	5-HT1A	71,77	ipsapirone	5-HT1A	MESH:C043077	24473(Tax:10116)	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|nummod|END_ENTITY	-LSB- Behavioral pharmacological and electroencephalographic effects of the 5-HT1A partial agonist ipsapirone -RSB- .
2623048	0	ipsapirone	78,88	5-HT1A	54,60	ipsapirone	5-HT1A	MESH:C043077	24473(Tax:10116)	Chemical	Gene	selective|nmod|START_ENTITY selective|dobj|antagonist antagonist|nummod|END_ENTITY	In vivo interactions of NAN-190 , a putative selective 5-HT1A antagonist , with ipsapirone .
7690117	0	ipsapirone	62,72	5-HT1A	4,10	ipsapirone	5-HT1A	MESH:C043077	24473(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY involved|nmod|effect involved|nsubjpass|autoreceptors autoreceptors|nummod|END_ENTITY	Are 5-HT1A autoreceptors involved in the inhibitory effect of ipsapirone on cold-elicited thyrotropin secretion ?
7691626	0	ipsapirone	50,60	5-HT1A	26,32	ipsapirone	5-HT1A	MESH:C043077	24473(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|agonist agonist|nummod|END_ENTITY	Anxiolytic effects of the 5-HT1A receptor agonist ipsapirone in the rat : neurobiological correlates .
7753966	0	ipsapirone	17,27	5-HT1A	31,37	ipsapirone	5-HT1A	MESH:C043077	3350	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	The influence of ipsapirone , a 5-HT1A agonist , on sleep patterns of healthy subjects .
7842512	0	ipsapirone	24,34	5-HT1A	45,51	ipsapirone	5-HT1A	MESH:C043077	24473(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|nummod|END_ENTITY	Neurotrophic effects of ipsapirone and other 5-HT1A receptor agonists on septal cholinergic neurons in culture .
7903466	0	ipsapirone	90,100	5-HT1A	49,55	ipsapirone	5-HT1A	MESH:C043077	24473(Tax:10116)	Chemical	Gene	effects|amod|START_ENTITY alter|dobj|effects alter|nsubj|treatment treatment|nmod|dose dose|nmod|ipsapirone ipsapirone|nummod|END_ENTITY	Chronic treatment with an anxiolytic dose of the 5-HT1A agonist ipsapirone does not alter ipsapirone acute neuroendocrine effects .
7993956	0	ipsapirone	55,65	5-HT1A	40,46	ipsapirone	5-HT1A	MESH:C043077	24473(Tax:10116)	Chemical	Gene	Attenuation|amod|START_ENTITY Attenuation|nmod|responses responses|nmod|agonist agonist|nummod|END_ENTITY	Attenuation of hormone responses to the 5-HT1A agonist ipsapirone by long-term treatment with fluoxetine , but not desipramine , in male rats .
8666006	0	ipsapirone	51,61	5-HT1A	12,18	ipsapirone	5-HT1A	MESH:C043077	24473(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY mediate|dobj|effect mediate|nsubj|receptors receptors|amod|END_ENTITY	Presynaptic 5-HT1A receptors mediate the effect of ipsapirone on punished responding in rats .
9105877	0	ipsapirone	19,29	5-HT1A	124,130	ipsapirone	5-HT1A	MESH:C043077	24473(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY Effect|nmod|treatment Effect|dep|role role|nmod|receptors receptors|nummod|END_ENTITY	Effect of repeated ipsapirone treatment on hippocampal excitatory synaptic transmission in the freely behaving rat : role of 5-HT1A receptors and relationship to anxiolytic effect .
9988364	0	ipsapirone	75,85	5-HT1A_receptor	42,57	ipsapirone	5-HT1A receptor	MESH:C043077	3350	Chemical	Gene	stimulation|nmod|START_ENTITY stimulation|amod|END_ENTITY	Neuroendocrine and hypothermic effects of 5-HT1A_receptor stimulation with ipsapirone in healthy men : a placebo-controlled study .
7701045	0	ipsapirone	27,37	5HT1A	41,46	ipsapirone	5HT1A	MESH:C043077	3350	Chemical	Gene	START_ENTITY|appos|agonist agonist|nummod|END_ENTITY	Inhibition of REM sleep by ipsapirone , a 5HT1A agonist , in normal volunteers .
1352246	0	ipsapirone	26,36	CRF	81,84	ipsapirone	CRF	MESH:C043077	1392	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|END_ENTITY	Neuroendocrine effects of ipsapirone on the hypothalamic-pituitary_adrenal_axis : CRF , ACTH and cortisol in healthy volunteers .
8106004	0	ipsapirone	26,36	TRH	72,75	ipsapirone	TRH	MESH:C043077	7200	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|compound|END_ENTITY	Antidepressant/anxiolytic ipsapirone inhibits cold-induced hypothalamic TRH release .
20584672	0	irbesartan	11,21	ACE2	25,29	irbesartan	ACE2	MESH:C081309	302668(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	-LSB- Effect of irbesartan on ACE2 expression in diabetic rat myocardium -RSB- .
15526904	0	irbesartan	47,57	AT1	71,74	irbesartan	AT1	MESH:C081309	24180(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Amelioration of cyclosporine nephrotoxicity by irbesartan , A selective AT1 receptor antagonist .
7843749	0	irbesartan	67,77	AT1	43,46	irbesartan	AT1	MESH:C081309	185	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|antagonist antagonist|compound|END_ENTITY	Hemodynamic and biochemical effects of the AT1 receptor antagonist irbesartan in hypertension .
10079000	0	irbesartan	35,45	angiotensin_II	83,97	irbesartan	angiotensin II	MESH:C081309	24179(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|responses responses|nmod|END_ENTITY	Effects of systemic treatment with irbesartan and losartan on central responses to angiotensin_II in conscious , normotensive rats .
17767044	0	irbesartan	46,56	cardiotrophin-1	15,30	irbesartan	cardiotrophin-1	MESH:C081309	29201(Tax:10116)	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of cardiotrophin-1 and effects of irbesartan in adriamycin induced cardiomyopathy in rats -RSB- .
22490592	0	irbesartan	76,86	integrin-linked_kinase	14,36	irbesartan	integrin-linked kinase	MESH:C081309	170922(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Inhibition of integrin-linked_kinase by angiotensin II receptor antagonist , irbesartan attenuates podocyte injury in diabetic rats .
8938669	0	ircinin	96,103	phospholipase_A2	14,30	ircinin	phospholipase A2	null	151056	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activities activities|amod|END_ENTITY	Inhibition of phospholipase_A2 activities and some inflammatory responses by the marine product ircinin .
19522499	0	iridium	24,31	PBP	13,16	iridium	PBP	MESH:D007495	1795	Chemical	Gene	complexes|compound|START_ENTITY complexes|compound|END_ENTITY	Syntheses of PBP pincer iridium complexes : a supporting boryl ligand .
11348221	0	iridoid	14,21	AP-1	62,66	iridoid	AP-1	null	16476(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	A new unusual iridoid with inhibition of activator_protein-1 -LRB- AP-1 -RRB- from the leaves of Morinda citrifolia L. -LSB- structure in text -RSB- From the leaves of Morinda citrifolia , a new unusual iridoid , named citrifolinoside -LRB- 1 -RRB- , showing significant inhibition of UVB-induced Activator_Protein-1 -LRB- AP-1 -RRB- activity in cell cultures , has been isolated .
26351040	0	iridoids	57,65	COX-1	9,14	iridoids	COX-1	MESH:D039823	5742	Chemical	Gene	activities|nmod|START_ENTITY activities|amod|END_ENTITY	In vitro COX-1 and COX-2 enzyme inhibitory activities of iridoids from Penstemon barbatus , Castilleja tenuiflora , Cresentia alata and Vitex mollis .
12612446	0	iridoids	11,19	lipoxygenase	23,35	iridoids	lipoxygenase	MESH:D039823	547836(Tax:3847)	Chemical	Gene	START_ENTITY|nmod|activities activities|amod|END_ENTITY	Effects of iridoids on lipoxygenase and hyaluronidase activities and their activation by beta-glucosidase in the presence of amino_acids .
22044840	0	irinotecan	16,26	5-HT3A	46,52	irinotecan	5-HT3A	MESH:C051890	3359	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Anticancer drug irinotecan inhibits homomeric 5-HT3A and heteromeric 5-HT3AB receptor responses .
10091755	0	irinotecan	40,50	CPT-11	52,58	irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	trial|nmod|START_ENTITY trial|appos|END_ENTITY	A multicenter , phase II trial of weekly irinotecan -LRB- CPT-11 -RRB- in patients with previously treated colorectal_carcinoma .
10211088	0	irinotecan	33,43	CPT-11	45,51	irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	activity|nmod|START_ENTITY activity|appos|END_ENTITY	Clinical activity and benefit of irinotecan -LRB- CPT-11 -RRB- in patients with colorectal_cancer truly resistant to 5-fluorouracil -LRB- 5-FU -RRB- .
10222654	0	irinotecan	34,44	CPT-11	46,52	irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	treatment|nmod|START_ENTITY treatment|appos|END_ENTITY	Successful salvage treatment with irinotecan -LRB- CPT-11 -RRB- of recurrent malignant_lymphoma in an aged patient ; and CPT-11 pharmacokinetics .
10658525	0	irinotecan	8,18	CPT-11	0,6	irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	addition|compound|START_ENTITY addition|compound|END_ENTITY	CPT-11 -LRB- irinotecan -RRB- addition to bimonthly , high-dose leucovorin and bolus and continuous-infusion 5-fluorouracil -LRB- FOLFIRI -RRB- for pretreated metastatic colorectal_cancer .
10725311	0	irinotecan	47,57	CPT-11	101,107	irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	Pharmacokinetics|nmod|START_ENTITY -RSB-|nsubj|Pharmacokinetics -RSB-|dobj|END_ENTITY	Pharmacokinetics , metabolism , and excretion of irinotecan -LRB- CPT-11 -RRB- following I.V. infusion of -LSB- -LRB- 14 -RRB- C -RSB- CPT-11 in cancer patients .
10725311	0	irinotecan	47,57	CPT-11	59,65	irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	Pharmacokinetics|nmod|START_ENTITY Pharmacokinetics|appos|END_ENTITY	Pharmacokinetics , metabolism , and excretion of irinotecan -LRB- CPT-11 -RRB- following I.V. infusion of -LSB- -LRB- 14 -RRB- C -RSB- CPT-11 in cancer patients .
10815927	0	irinotecan	14,24	CPT-11	26,32	irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	Metabolism|nmod|START_ENTITY Metabolism|appos|END_ENTITY	Metabolism of irinotecan -LRB- CPT-11 -RRB- by CYP3A4 and CYP3A5 in humans .
10830136	0	irinotecan	37,47	CPT-11	49,55	irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	binding|nmod|START_ENTITY binding|appos|END_ENTITY	In vitro binding and partitioning of irinotecan -LRB- CPT-11 -RRB- and its metabolite , SN-38 , in human blood .
11137204	0	irinotecan	27,37	CPT-11	39,45	irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	A dose-escalation study of irinotecan -LRB- CPT-11 -RRB- in combination with cisplatin in patients with advanced non-small_cell_lung_cancer previously treated with a docetaxel-based front line chemotherapy .
11340371	0	irinotecan	24,34	CPT-11	36,42	irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	A dose-finding study of irinotecan -LRB- CPT-11 -RRB- plus a four-day continuous 5-fluorouracil infusion in advanced colorectal_cancer .
11398883	0	irinotecan	20,30	CPT-11	32,38	irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	trial|nmod|START_ENTITY trial|appos|END_ENTITY	A phase II trial of irinotecan -LRB- CPT-11 -RRB- for unresectable biliary tree carcinoma .
11507714	0	irinotecan	143,153	CPT-11	155,161	irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	metabolite|nmod|START_ENTITY SN-38|appos|metabolite activity|nmod|SN-38 assay|nmod|activity assay|appos|END_ENTITY	High-performance liquid chromatographic assay for glucuronidation activity of 7-ethyl-10-hydroxycamptothecin -LRB- SN-38 -RRB- , the active metabolite of irinotecan -LRB- CPT-11 -RRB- , in human liver microsomes .
11822765	0	irinotecan	50,60	CPT-11	62,68	irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	dose-finding|nmod|START_ENTITY dose-finding|appos|END_ENTITY	Phase I dose-finding and pharmacokinetic trial of irinotecan -LRB- CPT-11 -RRB- administered every two weeks .
12006511	0	irinotecan	118,128	CPT-11	130,136	irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	combination|nmod|START_ENTITY IMC-C225|nmod|combination activity|nmod|IMC-C225 activity|appos|END_ENTITY	Enhanced antitumor activity of anti-epidermal_growth_factor_receptor monoclonal antibody IMC-C225 in combination with irinotecan -LRB- CPT-11 -RRB- against human colorectal_tumor xenografts .
12061727	0	irinotecan	22,32	CPT-11	34,40	irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Antitumoral effect of irinotecan -LRB- CPT-11 -RRB- on an experimental model of malignant neuroectodermal_tumor .
12168889	0	irinotecan	27,37	CPT-11	39,45	irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	A dose-escalation study of irinotecan -LRB- CPT-11 -RRB- in combination with gemcitabine in patients with advanced non-small_cell_lung_cancer previously treated with a cisplatin-based front line chemotherapy .
12269768	0	irinotecan	44,54	CPT-11	56,62	irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	administrations|nmod|START_ENTITY administrations|appos|END_ENTITY	Intermittent , repetitive administrations of irinotecan -LRB- CPT-11 -RRB- reduces its side-effects .
12485959	0	irinotecan	83,93	CPT-11	95,101	irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	metabolite|nmod|START_ENTITY SN-38|appos|metabolite Glucuronidation|nmod|SN-38 Glucuronidation|appos|END_ENTITY	Glucuronidation of 7-ethyl-10-hydroxycamptothecin -LRB- SN-38 -RRB- , an active metabolite of irinotecan -LRB- CPT-11 -RRB- , by human UGT1A1 variants , G71R , P229Q , and Y486D .
12665683	0	irinotecan	25,35	CPT-11	37,43	irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Phase II study of weekly irinotecan -LRB- CPT-11 -RRB- as second-line treatment of patients with advanced colorectal_cancer .
12774248	0	irinotecan	17,27	CPT-11	29,35	irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	A pilot study of irinotecan -LRB- CPT-11 -RRB- as single-agent therapy in patients with locally advanced or metastatic esophageal_carcinoma .
12851783	0	irinotecan	32,42	CPT-11	44,50	irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	A multicenter phase II study of irinotecan -LRB- CPT-11 -RRB- alternated with 5-fluorouracil and leucovorin as first-line treatment of patients with metastatic colorectal_cancer .
14504920	0	irinotecan	27,37	CPT-11	39,45	irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	schedules|nmod|START_ENTITY schedules|appos|END_ENTITY	Two different schedules of irinotecan -LRB- CPT-11 -RRB- in patients with advanced colorectal_carcinoma relapsing after a 5-fluorouracil and leucovorin combination .
14586214	0	irinotecan	19,29	CPT-11	31,37	irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	Activity|nmod|START_ENTITY Activity|appos|END_ENTITY	Activity of weekly irinotecan -LRB- CPT-11 -RRB- in patients with advanced non-small_cell_lung_cancer pretreated with platinum and taxanes .
15013590	0	irinotecan	25,35	CPT-11	37,43	irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	administration|nmod|START_ENTITY administration|appos|END_ENTITY	Weekly administration of irinotecan -LRB- CPT-11 -RRB- plus cisplatin for refractory or relapsed small_cell_lung_cancer .
15457123	0	irinotecan	18,28	CPT-11	30,36	irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Phase II study of irinotecan -LRB- CPT-11 -RRB- administered every 2 weeks as treatment for patients with colorectal_cancer resistant to previous treatment with 5-fluorouracil-based therapies : comparison of two different dose schedules -LRB- 250 and 200 mg/m2 -RRB- according to toxicity prognostic factors .
15612023	0	irinotecan	18,28	CPT-11	30,36	irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Phase II study of irinotecan -LRB- CPT-11 -RRB- as salvage therapy for advanced nasopharyngeal_carcinoma .
15818508	0	irinotecan	33,43	CPT-11	45,51	irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	study|nmod|START_ENTITY combined|nsubj|study combined|dep|END_ENTITY	A phase I , dose-finding study of irinotecan -LRB- CPT-11 -RRB- short i.v. infusion combined with fixed dose of 5-fluorouracil -LRB- 5-FU -RRB- protracted i.v. infusion in adult patients with advanced solid tumours .
16101180	0	irinotecan	30,40	CPT-11	42,48	irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	combination|nmod|START_ENTITY Docetaxel|nmod|combination Docetaxel|appos|END_ENTITY	Docetaxel in combination with irinotecan -LRB- CPT-11 -RRB- in platinum-resistant paclitaxel-pretreated ovarian_cancer .
16131447	0	irinotecan	30,40	CPT-11	42,48	irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	trial|nmod|START_ENTITY trial|appos|END_ENTITY	Phase II trial of fortnightly irinotecan -LRB- CPT-11 -RRB- in the treatment of colorectal_cancer patients resistant to previous fluoropyrimidine-based chemotherapy .
16184926	0	irinotecan	42,52	CPT-11	54,60	irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	chemotherapy|nmod|START_ENTITY evaluation|nmod|chemotherapy evaluation|appos|END_ENTITY	-LSB- Clinical evaluation of chemotherapy with irinotecan -LRB- CPT-11 -RRB- , l-leucovorin -LRB- l-LV -RRB- , 5-fluorouracil -LRB- 5-FU -RRB- , and UFT for metastatic or recurrent colorectal_cancer -RSB- .
16600980	0	irinotecan	80,90	CPT-11	92,98	irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	formulation|nmod|START_ENTITY study|nmod|formulation dose-finding|dobj|study phase|acl:relcl|dose-finding phase|appos|END_ENTITY	A phase I dose-finding clinical pharmacokinetic study of an oral formulation of irinotecan -LRB- CPT-11 -RRB- administered for 5 days every 3 weeks in patients with advanced solid tumours .
16842384	0	irinotecan	27,37	CPT-11	39,45	irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	metabolism|nmod|START_ENTITY END_ENTITY|nsubj|metabolism	The in vitro metabolism of irinotecan -LRB- CPT-11 -RRB- by carboxylesterase and beta-glucuronidase in human colorectal_tumours .
16937104	0	irinotecan	107,117	CPT-11	99,105	irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	activity|appos|START_ENTITY activity|nmod|erlotinib erlotinib|nmod|END_ENTITY	Antitumor activity of HER1/EGFR tyrosine kinase inhibitor erlotinib , alone and in combination with CPT-11 -LRB- irinotecan -RRB- in human colorectal_cancer xenograft models .
17063397	0	irinotecan	53,63	CPT-11	65,71	irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	encapsulation|nmod|START_ENTITY encapsulation|appos|END_ENTITY	Transition_metal-mediated liposomal encapsulation of irinotecan -LRB- CPT-11 -RRB- stabilizes the drug in the therapeutically active lactone conformation .
17214329	0	irinotecan	25,35	CPT-11	37,43	irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	administration|nmod|START_ENTITY administration|appos|END_ENTITY	Weekly administration of irinotecan -LRB- CPT-11 -RRB- plus cisplatin for non-small_cell_lung_cancer .
18761148	0	irinotecan	129,139	CPT-11	141,147	irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	quantification|nmod|START_ENTITY utilizing|nmod|quantification utilizing|dep|END_ENTITY	Development and validation of reversed phase liquid chromatographic method utilizing ultraviolet detection for quantification of irinotecan -LRB- CPT-11 -RRB- and its active metabolite , SN-38 , in rat plasma and bile samples : application to pharmacokinetic studies .
18771527	0	irinotecan	96,106	CPT-11	108,114	irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	inhibitor|appos|START_ENTITY efficacy|nmod|inhibitor results|nmod|efficacy Overexpression|nmod|results Overexpression|appos|END_ENTITY	Overexpression of carboxylesterase-2 results in enhanced efficacy of topoisomerase I inhibitor , irinotecan -LRB- CPT-11 -RRB- , for multiple_myeloma .
20066473	0	irinotecan	57,67	CPT-11	69,75	irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	xenografts|nmod|START_ENTITY treatment|nmod|xenografts treatment|appos|END_ENTITY	Metronomic treatment of malignant_glioma xenografts with irinotecan -LRB- CPT-11 -RRB- inhibits angiogenesis and tumor growth .
25474134	0	irinotecan	44,54	CPT-11	56,62	irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	efficiency|amod|START_ENTITY efficiency|compound|END_ENTITY	MBL-II-141 , a chromone derivative , enhances irinotecan -LRB- CPT-11 -RRB- anticancer efficiency in ABCG2-positive xenografts .
7786821	0	irinotecan	37,47	CPT-11	49,55	irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	I|nmod|START_ENTITY I|appos|END_ENTITY	Phase I and pharmacokinetic study of irinotecan -LRB- CPT-11 -RRB- administered daily for three consecutive days every three weeks in patients with advanced solid tumors .
8706009	0	irinotecan	62,72	CPT-11	74,80	irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	metabolite|nmod|START_ENTITY Identification|nmod|metabolite Identification|appos|END_ENTITY	Identification and properties of a major plasma metabolite of irinotecan -LRB- CPT-11 -RRB- isolated from the plasma of patients .
8826613	0	irinotecan	80,90	CPT-11	92,98	irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	activity|nmod|START_ENTITY activity|appos|END_ENTITY	Experimental antitumor activity and pharmacokinetics of the camptothecin analog irinotecan -LRB- CPT-11 -RRB- in mice .
8922198	0	irinotecan	49,59	CPT-11	41,47	irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	Rationale|appos|START_ENTITY Rationale|nmod|dosage dosage|nmod|END_ENTITY	Rationale for the dosage and schedule of CPT-11 -LRB- irinotecan -RRB- selected for phase II studies , as determined by European phase I studies .
8943660	0	irinotecan	20,30	CPT-11	12,18	irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	Efficacy|appos|START_ENTITY Efficacy|nmod|END_ENTITY	Efficacy of CPT-11 -LRB- irinotecan -RRB- as a single agent in metastatic colorectal_cancer .
9255427	0	irinotecan	132,142	CPT-11	144,150	irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	metabolite|nmod|START_ENTITY SN-38|appos|metabolite forms|nmod|SN-38 determination|nmod|forms determination|appos|END_ENTITY	Simultaneous determination of the lactone and carboxylate forms of 7-ethyl-10-hydroxycamptothecin -LRB- SN-38 -RRB- , the active metabolite of irinotecan -LRB- CPT-11 -RRB- , in rat plasma by high performance liquid chromatography .
9272733	0	irinotecan	22,32	CPT-11	34,40	irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	transformation|nmod|START_ENTITY transformation|appos|END_ENTITY	The transformation of irinotecan -LRB- CPT-11 -RRB- to its active metabolite SN-38 by human liver microsomes .
9445190	0	irinotecan	20,30	CPT-11	32,38	irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	A phase II study of irinotecan -LRB- CPT-11 -RRB- in patients with advanced squamous_cell_carcinoma_of_the_cervix .
9554593	0	irinotecan	15,25	CPT-11	27,33	irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Enhancement of irinotecan -LRB- CPT-11 -RRB- activity against central_nervous_system_tumor xenografts by alkylating agents .
9568166	0	irinotecan	98,108	CPT-11	110,116	irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	administration|compound|START_ENTITY administration|appos|END_ENTITY	Mobilization of peripheral blood stem cells in patients with advanced thoracic_malignancies after irinotecan -LRB- CPT-11 -RRB- administration .
9635592	0	irinotecan	117,127	CPT-11	129,135	irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	activates|dobj|START_ENTITY liver_carboxylesterase|acl:relcl|activates liver_carboxylesterase|dep|END_ENTITY	Isolation and partial characterization of a cDNA encoding a rabbit liver_carboxylesterase that activates the prodrug irinotecan -LRB- CPT-11 -RRB- .
9682163	0	irinotecan	46,56	CPT-11	58,64	irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	products|nmod|START_ENTITY products|appos|END_ENTITY	The detection of photodegradation products of irinotecan -LRB- CPT-11 , Campto , Camptosar -RRB- , in clinical studies , using high-performance liquid chromatography/atmospheric pressure chemical ionisation/mass spectrometry .
9721871	0	irinotecan	85,95	CPT-11	97,103	irinotecan	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|appos|END_ENTITY	Cellular localization domains of a rabbit and a human carboxylesterase : influence on irinotecan -LRB- CPT-11 -RRB- metabolism by the rabbit enzyme .
10815927	0	irinotecan	14,24	CYP3A4	37,43	irinotecan	CYP3A4	MESH:C051890	1576	Chemical	Gene	Metabolism|nmod|START_ENTITY Metabolism|nmod|END_ENTITY	Metabolism of irinotecan -LRB- CPT-11 -RRB- by CYP3A4 and CYP3A5 in humans .
25322874	0	irinotecan	58,68	K-RAS	109,114	irinotecan	K-RAS	MESH:C051890	3845	Chemical	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	Phase II study of selumetinib -LRB- AZD6244 , ARRY-142886 -RRB- plus irinotecan as second-line therapy in patients with K-RAS mutated colorectal_cancer .
19603018	0	irinotecan	75,85	KRAS	0,4	irinotecan	KRAS	MESH:C051890	3845	Chemical	Gene	cetuximab|dobj|START_ENTITY predict|advcl|cetuximab predict|nsubj|codon codon|compound|END_ENTITY	KRAS codon 61 , 146 and BRAF mutations predict resistance to cetuximab plus irinotecan in KRAS codon 12 and 13 wild-type metastatic colorectal_cancer .
19603018	0	irinotecan	75,85	KRAS	89,93	irinotecan	KRAS	MESH:C051890	3845	Chemical	Gene	cetuximab|dobj|START_ENTITY cetuximab|nmod|colorectal_cancer colorectal_cancer|compound|END_ENTITY	KRAS codon 61 , 146 and BRAF mutations predict resistance to cetuximab plus irinotecan in KRAS codon 12 and 13 wild-type metastatic colorectal_cancer .
20072801	0	irinotecan	48,58	KRAS	137,141	irinotecan	KRAS	MESH:C051890	3845	Chemical	Gene	chemotherapy|nmod|START_ENTITY study|nmod|chemotherapy study|nmod|colorectal_cancer colorectal_cancer|acl|harboring harboring|dobj|END_ENTITY	Phase II study of combination chemotherapy with irinotecan and cetuximab for pretreated metastatic colorectal_cancer harboring wild-type KRAS .
20619672	0	irinotecan	32,42	KRAS	131,135	irinotecan	KRAS	MESH:C051890	3845	Chemical	Gene	failure|compound|START_ENTITY Cetuximab|nmod|failure Cetuximab|dep|outcome outcome|nmod|status status|compound|END_ENTITY	Cetuximab plus irinotecan after irinotecan failure in elderly metastatic colorectal_cancer patients : clinical outcome according to KRAS and BRAF mutational status .
21104178	0	irinotecan	148,158	KRAS	64,68	irinotecan	KRAS	MESH:C051890	3845	Chemical	Gene	treated|nmod|START_ENTITY patients|acl|treated status|nmod|patients correlates|dobj|status correlates|nmod|survival survival|nmod|END_ENTITY	Serum matrilysin correlates with poor survival independently of KRAS and BRAF status in refractory advanced colorectal_cancer patients treated with irinotecan plus cetuximab .
21502544	0	irinotecan	15,25	KRAS	170,174	irinotecan	KRAS	MESH:C051890	3845	Chemical	Gene	Cetuximab|dobj|START_ENTITY Cetuximab|nmod|END_ENTITY	Cetuximab plus irinotecan , fluorouracil , and leucovorin as first-line treatment for metastatic colorectal_cancer : updated analysis of overall survival according to tumor KRAS and BRAF mutation status .
21652203	0	irinotecan	123,133	KRAS	148,152	irinotecan	KRAS	MESH:C051890	3845	Chemical	Gene	START_ENTITY|nmod|metastatic_colorectal_cancer metastatic_colorectal_cancer|compound|END_ENTITY	Sensitivity to previous irinotecan treatment does not predict the efficacy of combination chemotherapy with cetuximab plus irinotecan for wild-type KRAS metastatic_colorectal_cancer .
22638623	0	irinotecan	103,113	KRAS	23,27	irinotecan	KRAS	MESH:C051890	3845	Chemical	Gene	patients|amod|START_ENTITY mutations|nmod|patients mutations|nsubj|usefulness usefulness|nmod|END_ENTITY	Clinical usefulness of KRAS , BRAF , and PIK3CA mutations as predictive markers of cetuximab efficacy in irinotecan - and oxaliplatin-refractory Japanese patients with metastatic colorectal_cancer .
23041588	0	irinotecan	26,36	KRAS	55,59	irinotecan	KRAS	MESH:C051890	3845	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	Panitumumab combined with irinotecan for patients with KRAS wild-type metastatic colorectal_cancer refractory to standard chemotherapy : a GERCOR efficacy , tolerance , and translational molecular study .
23071293	0	irinotecan	128,138	KRAS	82,86	irinotecan	KRAS	MESH:C051890	3845	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|outcome outcome|nmod|patients patients|acl|harbouring harbouring|dobj|mutation mutation|compound|END_ENTITY	Clinical outcome of Japanese metastatic colorectal_cancer patients harbouring the KRAS p.G13D mutation treated with cetuximab + irinotecan .
23116683	0	irinotecan	125,135	KRAS	42,46	irinotecan	KRAS	MESH:C051890	3845	Chemical	Gene	cetuximab|nmod|START_ENTITY treated|nmod|cetuximab treated|nsubj|Quality Quality|nmod|analysis analysis|nmod|patients patients|nmod|colorectal_cancer colorectal_cancer|compound|END_ENTITY	Quality of life analysis in patients with KRAS wild-type metastatic colorectal_cancer treated first-line with cetuximab plus irinotecan , fluorouracil and leucovorin .
23328486	0	irinotecan	166,176	KRAS	91,95	irinotecan	KRAS	MESH:C051890	3845	Chemical	Gene	progressed|nmod|START_ENTITY tumors|acl:relcl|progressed END_ENTITY|dobj|tumors	A phase II study of high-dose cetuximab plus irinotecan in colorectal_cancer patients with KRAS wild-type tumors who progressed after standard dose of cetuximab plus irinotecan .
23328486	0	irinotecan	45,55	KRAS	91,95	irinotecan	KRAS	MESH:C051890	3845	Chemical	Gene	cetuximab|acl|START_ENTITY study|nmod|cetuximab END_ENTITY|nsubj|study	A phase II study of high-dose cetuximab plus irinotecan in colorectal_cancer patients with KRAS wild-type tumors who progressed after standard dose of cetuximab plus irinotecan .
23514584	0	irinotecan	61,71	KRAS	76,80	irinotecan	KRAS	MESH:C051890	3845	Chemical	Gene	START_ENTITY|nmod|colorectal_cancer colorectal_cancer|compound|END_ENTITY	Phase II trial of temsirolimus alone and in combination with irinotecan for KRAS mutant metastatic colorectal_cancer : outcome and results of KRAS mutational analysis in plasma .
23725851	0	irinotecan	34,44	KRAS	69,73	irinotecan	KRAS	MESH:C051890	3845	Chemical	Gene	Panitumumab|nmod|START_ENTITY Panitumumab|amod|wild-type wild-type|advmod|alone alone|nmod|patients patients|nmod|END_ENTITY	Panitumumab and irinotecan versus irinotecan alone for patients with KRAS wild-type , fluorouracil-resistant advanced colorectal_cancer -LRB- PICCOLO -RRB- : a prospectively stratified randomised trial .
25319061	0	irinotecan	40,50	KRAS	108,112	irinotecan	KRAS	MESH:C051890	3845	Chemical	Gene	combined|nmod|START_ENTITY combined|nmod|patients patients|nmod|colorectal_cancer colorectal_cancer|compound|END_ENTITY	Abituzumab combined with cetuximab plus irinotecan versus cetuximab plus irinotecan alone for patients with KRAS wild-type metastatic colorectal_cancer : the randomised phase I/II POSEIDON trial .
25319061	0	irinotecan	73,83	KRAS	108,112	irinotecan	KRAS	MESH:C051890	3845	Chemical	Gene	alone|nmod:npmod|START_ENTITY patients|advmod|alone patients|nmod|colorectal_cancer colorectal_cancer|compound|END_ENTITY	Abituzumab combined with cetuximab plus irinotecan versus cetuximab plus irinotecan alone for patients with KRAS wild-type metastatic colorectal_cancer : the randomised phase I/II POSEIDON trial .
26486455	0	irinotecan	138,148	KRAS	57,61	irinotecan	KRAS	MESH:C051890	3845	Chemical	Gene	cetuximab|nmod|START_ENTITY received|dobj|cetuximab patients|acl:relcl|received biomarker|nsubj|patients biomarker|nmod|response response|nmod|type type|compound|END_ENTITY	Exploratory biomarker analysis for treatment response in KRAS wild type metastatic colorectal_cancer patients who received cetuximab plus irinotecan .
26891420	0	irinotecan	94,104	KRAS	180,184	irinotecan	KRAS	MESH:C051890	3845	Chemical	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	A randomized , placebo-controlled , phase 1/2 study of tivantinib -LRB- ARQ_197 -RRB- in combination with irinotecan and cetuximab in patients with metastatic colorectal_cancer with wild-type KRAS who have received first-line systemic therapy .
15608127	0	irinotecan	72,82	OATP1B1	34,41	irinotecan	OATP1B1	MESH:C051890	10599	Chemical	Gene	uptake|nmod|START_ENTITY END_ENTITY|nmod|uptake	Role of organic anion transporter OATP1B1 -LRB- OATP-C -RRB- in hepatic uptake of irinotecan and its active metabolite , 7-ethyl-10-hydroxycamptothecin : in vitro evidence and effect of single nucleotide polymorphisms .
19135530	0	irinotecan	95,105	P-glycoprotein	10,24	irinotecan	P-glycoprotein	MESH:C051890	287115(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|inhibitor inhibitor|amod|END_ENTITY	Effect of P-glycoprotein inhibitor , verapamil , on oral bioavailability and pharmacokinetics of irinotecan in rats .
20164124	0	irinotecan	110,120	P53	136,139	irinotecan	P53	MESH:C051890	7157	Chemical	Gene	response|nmod|START_ENTITY colorectal_cancers|nmod|response senescence|nmod|colorectal_cancers mediated|nsubjpass|senescence mediated|nmod|END_ENTITY	Secreted_protein_acidic_and_rich_in_cysteine-induced cellular senescence in colorectal_cancers in response to irinotecan is mediated by P53 .
15354215	0	irinotecan	53,63	S-1	89,92	irinotecan	DPD	MESH:C051890	1806	Chemical	Gene	therapy|compound|START_ENTITY therapy|nmod|END_ENTITY	Thymidylate synthase predictive power is overcome by irinotecan combination therapy with S-1 for gastric_cancer .
17106441	0	irinotecan	85,95	S-1	20,23	irinotecan	S-1	MESH:C051890	5707	Chemical	Gene	failure|nmod|START_ENTITY monotherapy|nmod|failure monotherapy|nsubj|trial trial|nmod|END_ENTITY	A phase II trial of S-1 monotherapy in metastatic colorectal_cancer after failure of irinotecan - and oxaliplatin-containing regimens .
18815728	0	irinotecan	29,39	S-1	20,23	irinotecan	S-1	MESH:C051890	5707	Chemical	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	A phase II study of S-1 plus irinotecan and oxaliplatin in heavily-treated patients with metastatic colorectal_cancer .
19318372	0	irinotecan	112,122	S-1	12,15	irinotecan	S-1	MESH:C051890	5707	Chemical	Gene	patients|nmod|START_ENTITY END_ENTITY|nmod|patients	Activity of S-1 in advanced or recurrent gastric_cancer patients after failure of prior chemotherapy , including irinotecan + cisplatin or fluorouracil -LRB- except S-1 -RRB- .
19318372	0	irinotecan	112,122	S-1	159,162	irinotecan	S-1	MESH:C051890	5707	Chemical	Gene	patients|nmod|START_ENTITY S-1|nmod|patients Activity|nmod|S-1 +|nsubj|Activity +|dep|END_ENTITY	Activity of S-1 in advanced or recurrent gastric_cancer patients after failure of prior chemotherapy , including irinotecan + cisplatin or fluorouracil -LRB- except S-1 -RRB- .
21340666	0	irinotecan	64,74	S-1	89,92	irinotecan	S-1	MESH:C051890	5707	Chemical	Gene	efficacy|nmod|START_ENTITY comparing|dobj|efficacy comparing|nmod|END_ENTITY	Randomized phase III study comparing the efficacy and safety of irinotecan plus S-1 with S-1 alone as first-line treatment for advanced gastric_cancer -LRB- study GC0301/TOP -002 -RRB- .
21512394	0	irinotecan	64,74	S-1	98,101	irinotecan	S-1	MESH:C051890	5707	Chemical	Gene	START_ENTITY|nmod|monotherapy monotherapy|compound|END_ENTITY	Randomized phase II trial of first-line treatment with tailored irinotecan and S-1 therapy versus S-1 monotherapy for advanced or recurrent gastric_carcinoma -LRB- JFMC31-0301 -RRB- .
22790052	0	irinotecan	214,224	S-1	154,157	irinotecan	S-1	MESH:C051890	5707	Chemical	Gene	followed|nmod|START_ENTITY followed|csubj|-LSB- -LSB-|nmod|dissemination dissemination|acl:relcl|achieved achieved|nmod|treatments treatments|nmod|END_ENTITY	-LSB- A case of gastric_cancer with peritoneal dissemination who achieved long survival from control of ascites for over 2 years by successive treatments with S-1 in combination with docetaxel as first-line followed by irinotecan in combination with cisplatin as second-line -RSB- .
25797356	0	irinotecan	42,52	S-1	147,150	irinotecan	S-1	MESH:C051890	5707	Chemical	Gene	cisplatin|compound|START_ENTITY trial|nmod|cisplatin trial|nmod|refractory refractory|nmod|monotherapy monotherapy|compound|END_ENTITY	Randomised phase III trial of second-line irinotecan plus cisplatin versus irinotecan alone in patients with advanced gastric_cancer refractory to S-1 monotherapy : TRICS trial .
25797356	0	irinotecan	75,85	S-1	147,150	irinotecan	S-1	MESH:C051890	5707	Chemical	Gene	cisplatin|nmod|START_ENTITY trial|nmod|cisplatin trial|nmod|refractory refractory|nmod|monotherapy monotherapy|compound|END_ENTITY	Randomised phase III trial of second-line irinotecan plus cisplatin versus irinotecan alone in patients with advanced gastric_cancer refractory to S-1 monotherapy : TRICS trial .
18082937	0	irinotecan	52,62	UDP-glucuronosyltransferase_1A1	14,45	irinotecan	UDP-glucuronosyltransferase 1A1	MESH:C051890	54658	Chemical	Gene	Importance|nmod|START_ENTITY Importance|nmod|END_ENTITY	Importance of UDP-glucuronosyltransferase_1A1 * 6 for irinotecan toxicities in Japanese cancer patients .
17510208	0	irinotecan	78,88	UGT1A1	0,6	irinotecan	UGT1A1	MESH:C051890	54658	Chemical	Gene	treated|nmod|START_ENTITY patients|acl|treated predict|nmod|patients predict|nsubj|polymorphism polymorphism|compound|END_ENTITY	UGT1A1 polymorphism can predict hematologic_toxicity in patients treated with irinotecan .
21740478	0	irinotecan	41,51	UGT1A1	93,99	irinotecan	UGT1A1	MESH:C051890	54658	Chemical	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	Genotype-directed , dose-finding study of irinotecan in cancer patients with UGT1A1 * 28 and/or UGT1A1 * 6 polymorphisms .
22676194	0	irinotecan	46,56	UGT1A1	14,20	irinotecan	UGT1A1	MESH:C051890	54658	Chemical	Gene	Impact|nmod|START_ENTITY Impact|nmod|END_ENTITY	Impact of the UGT1A1 * 28 allele on response to irinotecan : a systematic review and meta-analysis .
18172273	0	irinotecan	161,171	epidermal_growth_factor_receptor	91,123	irinotecan	epidermal growth factor receptor	MESH:C051890	1956	Chemical	Gene	kinase|nmod|START_ENTITY kinase|nsubj|inhibitor inhibitor|nmod|tyrosine tyrosine|compound|END_ENTITY	Phase I pharmacokinetic/pharmacodynamic study of EKB-569 , an irreversible inhibitor of the epidermal_growth_factor_receptor tyrosine kinase , in combination with irinotecan , 5-fluorouracil , and leucovorin -LRB- FOLFIRI -RRB- in first-line treatment of patients with metastatic colorectal_cancer .
16315940	0	irinotecan_hydrochloride	109,133	CPT-11	135,141	irinotecan hydrochloride	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Two cases of postoperative local skin recurrence of breast_cancer successfully treated with chemotherapy of irinotecan_hydrochloride -LRB- CPT-11 -RRB- -RSB- .
8031168	0	irinotecan_hydrochloride	85,109	CPT-11	111,117	irinotecan hydrochloride	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Preventive effect of TJ-14 , a kampo -LRB- Chinese herb -RRB- medicine , on diarrhea induced by irinotecan_hydrochloride -LRB- CPT-11 -RRB- -RSB- .
8210254	0	irinotecan_hydrochloride	24,48	CPT-11	50,56	irinotecan hydrochloride	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	-LSB- Late phase II study of irinotecan_hydrochloride -LRB- CPT-11 -RRB- in advanced gastric_cancer .
8210256	0	irinotecan_hydrochloride	33,57	CPT-11	59,65	irinotecan hydrochloride	CPT-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	-LSB- Late phase II clinical study of irinotecan_hydrochloride -LRB- CPT-11 -RRB- in the treatment of malignant_lymphoma and acute_leukemia .
26427876	0	iron	42,46	ATAD-3	11,17	iron	ATAD-3	MESH:D007501	174590(Tax:6239)	Chemical	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	C. _ elegans ATAD-3 modulates mitochondrial iron and heme homeostasis .
10809751	0	iron	35,39	ATPase	17,23	iron	ATPase	MESH:D007501	1769	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|END_ENTITY	A mammalian iron ATPase induced by iron .
19090990	0	iron	51,55	Abeta	42,47	iron	Abeta	MESH:D007501	351	Chemical	Gene	homeostasis|compound|START_ENTITY END_ENTITY|nmod|homeostasis	Physiological and pathological aspects of Abeta in iron homeostasis via 5 ` UTR in the APP mRNA and the therapeutic use of iron-chelators .
24682751	0	iron	24,28	Angiotensin_II	0,14	iron	Angiotensin II	MESH:D007501	183	Chemical	Gene	uptake|compound|START_ENTITY inhibits|dobj|uptake inhibits|nsubj|END_ENTITY	Angiotensin_II inhibits iron uptake and release in cultured neurons .
24786977	0	iron	52,56	Angiotensin_II	0,14	iron	Angiotensin II	MESH:D007501	183	Chemical	Gene	uptake|nmod|START_ENTITY inhibits|dobj|uptake inhibits|nsubj|END_ENTITY	Angiotensin_II inhibits uptake of transferrin-bound iron but not non-transferrin-bound iron by cultured astrocytes .
25096756	0	iron	49,53	Angiotensin_II	0,14	iron	Angiotensin II	MESH:D007501	11606(Tax:10090)	Chemical	Gene	transporters|compound|START_ENTITY expression|nmod|transporters alters|dobj|expression alters|nsubj|END_ENTITY	Angiotensin_II alters the expression of duodenal iron transporters , hepatic hepcidin , and body iron distribution in mice .
21742768	0	iron	20,24	AtIRT1	0,6	iron	AtIRT1	MESH:D007501	827713(Tax:3702)	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|appos|transporter	AtIRT1 , the primary iron uptake transporter in the root , mediates excess nickel accumulation in Arabidopsis_thaliana .
26560141	0	iron	108,112	AtIRT1	24,30	iron	AtIRT1	MESH:D007501	827713(Tax:3702)	Chemical	Gene	increase|dobj|START_ENTITY promoter-controlled|advcl|increase promoter-controlled|dobj|functions functions|amod|END_ENTITY	NOD promoter-controlled AtIRT1 expression functions synergistically with NAS and FERRITIN genes to increase iron in rice grains .
9428742	0	iron	56,60	Atm1p	20,25	iron	Atm1p	MESH:D007501	22	Chemical	Gene	homeostasis|compound|START_ENTITY required|nmod|homeostasis required|nsubjpass|END_ENTITY	The ABC transporter Atm1p is required for mitochondrial iron homeostasis .
23605050	0	iron	16,20	Bcl2	80,84	iron	Bcl2	MESH:D007501	596	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of high iron and glucose concentrations over the relative expression of Bcl2 , Bax , and Mfn2 in MIN6 cells .
24454764	0	iron	56,60	Bmp6	0,4	iron	Bmp6	MESH:D007501	12161(Tax:10090)	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	Bmp6 expression can be regulated independently of liver iron in mice .
19554531	0	iron	41,45	C-reactive_protein	1,19	iron	C-reactive protein	MESH:D007501	1401	Chemical	Gene	status|compound|START_ENTITY assessment|nmod|status END_ENTITY|nmod|assessment	-LSB- C-reactive_protein in the assessment of iron status in patients on hemodialysis -RSB- .
18508159	0	iron	83,87	CCl4	49,53	iron	CCl4	MESH:D007501	6351	Chemical	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	Influence of Na2S on the degradation kinetics of CCl4 in the presence of very pure iron .
10077651	0	iron	23,27	DMT1	140,144	iron	DMT1	MESH:D007501	18174(Tax:10090)	Chemical	Gene	absorption|compound|START_ENTITY Mechanism|nmod|absorption Mechanism|dep|expression expression|nmod|END_ENTITY	Mechanism of increased iron absorption in murine model of hereditary_hemochromatosis : increased duodenal expression of the iron transporter DMT1 .
10582331	0	iron	4,8	DMT1	21,25	iron	DMT1	MESH:D007501	4891	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|nsubj|transporter	The iron transporter DMT1 .
10872742	0	iron	32,36	DMT1	94,98	iron	DMT1	MESH:D007501	18174(Tax:10090)	Chemical	Gene	distribution|nmod|START_ENTITY distribution|appos|END_ENTITY	Cellular distribution of ferric iron , ferritin , transferrin and divalent_metal_transporter_1 -LRB- DMT1 -RRB- in substantia nigra and basal ganglia of normal and beta2-microglobulin deficient mouse brain .
11093950	0	iron	48,52	DMT1	43,47	iron	DMT1	MESH:D007501	1761	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Functional properties of transfected human DMT1 iron transporter .
11159549	0	iron	37,41	DMT1	18,22	iron	DMT1	MESH:D007501	18174(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Expression of the DMT1 -LRB- NRAMP2/DCT1 -RRB- iron transporter in mice with genetic iron_overload_disorders .
12081573	0	iron	18,22	DMT1	35,39	iron	DMT1	MESH:D007501	18174(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY Expression|nmod|transporter END_ENTITY|nsubj|Expression	Expression of the iron transporter DMT1 in kidney from normal and anemic mk mice .
12181184	0	iron	10,14	DMT1	25,29	iron	DMT1	MESH:D007501	18174(Tax:10090)	Chemical	Gene	status|compound|START_ENTITY Effect|nmod|status Effect|nmod|expression expression|nummod|END_ENTITY	Effect of iron status on DMT1 expression in duodenal enterocytes from beta2-microglobulin knockout mice .
12388109	0	iron	28,32	DMT1	10,14	iron	DMT1	MESH:D007501	4891	Chemical	Gene	cadmium|compound|START_ENTITY knockdown|nmod|cadmium knockdown|nsubj|Effect Effect|nmod|END_ENTITY	Effect of DMT1 knockdown on iron , cadmium , and lead uptake in Caco-2 cells .
12584213	0	iron	122,126	DMT1	38,42	iron	DMT1	MESH:D007501	24906(Tax:10116)	Chemical	Gene	absorption|compound|START_ENTITY phenomenon|nmod|absorption explains|dobj|phenomenon explains|nsubj|decrease decrease|nmod|expression expression|nmod|END_ENTITY	A rapid decrease in the expression of DMT1 and Dcytb but not Ireg1 or hephaestin explains the mucosal_block phenomenon of iron absorption .
12753426	0	iron	10,14	DMT1	101,105	iron	DMT1	MESH:D007501	4891	Chemical	Gene	treatment|compound|START_ENTITY Effect|nmod|treatment Effect|appos|END_ENTITY	Effect of iron treatment on nickel absorption and gene expression of the divalent metal transporter -LRB- DMT1 -RRB- by human intestinal Caco-2 cells .
12876064	0	iron	16,20	DMT1	59,63	iron	DMT1	MESH:D007501	4891	Chemical	Gene	intake|compound|START_ENTITY modulator|nsubj|intake modulator|nmod|expression expression|compound|END_ENTITY	Altered dietary iron intake is a strong modulator of renal DMT1 expression .
12958019	0	iron	69,73	DMT1	0,4	iron	DMT1	MESH:D007501	24906(Tax:10116)	Chemical	Gene	absorption|compound|START_ENTITY regulation|nmod|absorption expression|dep|regulation expression|compound|END_ENTITY	DMT1 and FPN1 expression during infancy : developmental regulation of iron absorption .
14618243	0	iron	112,116	DMT1	130,134	iron	DMT1	MESH:D007501	18174(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY changes|nmod|expression independent|nmod|changes transporters|nsubj|independent transporters|dobj|END_ENTITY	Iron_overload in adult Hfe-deficient mice independent of changes in the steady-state expression of the duodenal iron transporters DMT1 and Ireg1/ferroportin .
14675167	0	iron	69,73	DMT1	60,64	iron	DMT1	MESH:D007501	24906(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY significance|nmod|transport significance|appos|END_ENTITY	The significance of the mutated divalent metal transporter -LRB- DMT1 -RRB- on iron transport into the Belgrade rat brain .
15247188	0	iron	51,55	DMT1	10,14	iron	DMT1	MESH:D007501	4891	Chemical	Gene	therapy|compound|START_ENTITY END_ENTITY|nmod|therapy	Increased DMT1 but not IREG1 or HFE mRNA following iron depletion therapy in hereditary_haemochromatosis .
16137791	6	iron	959,963	DMT1	998,1002	iron	DMT1	MESH:D007501	24906(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY increase|nmod|uptake associated|nsubjpass|increase associated|nmod|END_ENTITY	The data demonstrate that the increase in iron uptake is not associated with the DMT1 and TfR in NGF-treated PC12 cells .
16267047	0	iron	116,120	DMT1	46,50	iron	DMT1	MESH:D007501	4891	Chemical	Gene	absorption|compound|START_ENTITY pathway|nmod|absorption suggest|dobj|pathway suggest|nsubj|isoforms isoforms|nmod|transporter transporter|appos|END_ENTITY	Two isoforms of a divalent metal transporter -LRB- DMT1 -RRB- in Schistosoma_mansoni suggest a surface-associated pathway for iron absorption in schistosomes .
18189270	0	iron	83,87	DMT1	10,14	iron	DMT1	MESH:D007501	24906(Tax:10116)	Chemical	Gene	retention|compound|START_ENTITY mechanisms|nmod|retention mechanisms|nsubj|END_ENTITY	Decreased DMT1 and increased ferroportin_1 expression is the mechanisms of reduced iron retention in macrophages by erythropoietin in rats .
19553145	0	iron	31,35	DMT1	8,12	iron	DMT1	MESH:D007501	4891	Chemical	Gene	lead|xcomp|START_ENTITY lead|nsubj|mutations mutations|compound|END_ENTITY	Not all DMT1 mutations lead to iron overload .
20007457	0	iron	78,82	DMT1	96,100	iron	DMT1	MESH:D007501	4891	Chemical	Gene	transporters|compound|START_ENTITY transporters|amod|END_ENTITY	Iron supply determines apical/basolateral membrane distribution of intestinal iron transporters DMT1 and ferroportin_1 .
20232409	0	iron	36,40	DMT1	101,105	iron	DMT1	MESH:D007501	4891	Chemical	Gene	absorption-uncovering|compound|START_ENTITY mechanisms|nmod|absorption-uncovering based|nsubj|mechanisms based|nmod|endocytosis endocytosis|compound|END_ENTITY	Regulatory mechanisms of intestinal iron absorption-uncovering of a fast-response mechanism based on DMT1 and ferroportin endocytosis .
20681027	0	iron	30,34	DMT1	110,114	iron	DMT1	MESH:D007501	4891	Chemical	Gene	START_ENTITY|dobj|level level|nmod|Exon1B Exon1B|appos|END_ENTITY	Hypoxia regulates the ferrous iron uptake and reactive oxygen species level via divalent_metal_transporter_1 -LRB- DMT1 -RRB- Exon1B by hypoxia-inducible factor-1 .
20819077	0	iron	14,18	DMT1	123,127	iron	DMT1	MESH:D007501	4891	Chemical	Gene	accumulation|compound|START_ENTITY routes|nmod|accumulation routes|dep|uptake uptake|nmod|transporter transporter|appos|END_ENTITY	Two routes of iron accumulation in astrocytes : ascorbate-dependent ferrous iron uptake via the divalent metal transporter -LRB- DMT1 -RRB- plus an independent route for ferric iron .
20819077	0	iron	75,79	DMT1	123,127	iron	DMT1	MESH:D007501	4891	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|transporter transporter|appos|END_ENTITY	Two routes of iron accumulation in astrocytes : ascorbate-dependent ferrous iron uptake via the divalent metal transporter -LRB- DMT1 -RRB- plus an independent route for ferric iron .
23361852	0	iron	46,50	DMT1	0,4	iron	DMT1	MESH:D007501	24906(Tax:10116)	Chemical	Gene	candidate|nmod|START_ENTITY END_ENTITY|nmod|candidate	DMT1 as a candidate for non-transferrin-bound iron uptake in the peripheral nervous system .
25467637	0	iron	33,37	DMT1	85,89	iron	DMT1	MESH:D007501	4891	Chemical	Gene	accumulation|compound|START_ENTITY accumulation|acl|regulating regulating|dobj|degradation degradation|nmod|END_ENTITY	Ndfip1 attenuated 6-OHDA-induced iron accumulation via regulating the degradation of DMT1 .
25491917	0	iron	14,18	DMT1	82,86	iron	DMT1	MESH:D007501	1761	Chemical	Gene	uptake|compound|START_ENTITY Inhibition|nmod|uptake exerted|nsubjpass|Inhibition exerted|nmod|internalization internalization|nmod|END_ENTITY	Inhibition of iron uptake by ferristatin_II is exerted through internalization of DMT1 at the plasma membrane .
26106291	0	iron	77,81	DMT1	30,34	iron	DMT1	MESH:D007501	4891	Chemical	Gene	transport|compound|START_ENTITY role|nmod|transport implications|nmod|role Divalent_metal_transporter_1|dep|implications Divalent_metal_transporter_1|appos|END_ENTITY	Divalent_metal_transporter_1 -LRB- DMT1 -RRB- in the brain : implications for a role in iron transport at the blood-brain barrier , and neuronal and glial pathology .
26294671	0	iron	32,36	DMT1	11,15	iron	DMT1	MESH:D007501	18174(Tax:10090)	Chemical	Gene	absorption|compound|START_ENTITY critical|nmod|absorption critical|nsubj|END_ENTITY	Intestinal DMT1 is critical for iron absorption in the mouse but is not required for the absorption of copper or manganese .
26542333	0	iron	17,21	DMT1	12,16	iron	DMT1	MESH:D007501	1761	Chemical	Gene	uptake|compound|START_ENTITY END_ENTITY|dobj|uptake	Correction : DMT1 iron uptake in the PNS : bridging the gap between injury and regeneration .
12547225	0	iron	67,71	Dcytb	57,62	iron	Dcytb	MESH:D007501	79901	Chemical	Gene	metabolism|compound|START_ENTITY roles|nmod|metabolism roles|appos|END_ENTITY	Molecular and functional roles of duodenal_cytochrome_B -LRB- Dcytb -RRB- in iron metabolism .
16137899	0	iron	100,104	Dcytb	9,14	iron	Dcytb	MESH:D007501	79901	Chemical	Gene	homeostasis|compound|START_ENTITY variations|nmod|homeostasis modulated|nmod|variations modulated|nsubj|END_ENTITY	Duodenal Dcytb and hephaestin mRNA expression are not significantly modulated by variations in body iron homeostasis .
19021532	0	iron	21,25	Dcytb	12,17	iron	Dcytb	MESH:D007501	73649(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	The role of Dcytb in iron metabolism : an update .
23981688	0	iron	57,61	Dcytb	14,19	iron	Dcytb	MESH:D007501	79901	Chemical	Gene	expression|nmod|START_ENTITY expression|nsubj|Modulation Modulation|nmod|END_ENTITY	Modulation of Dcytb -LRB- Cybrd_1 -RRB- expression and function by iron , dehydroascorbate and Hif-2a in cultured cells .
16908409	0	iron	58,62	Dexras1	90,97	iron	Dexras1	MESH:D007501	51655	Chemical	Gene	homeostasis|compound|START_ENTITY homeostasis|nmod|END_ENTITY	NMDA receptor-nitric_oxide transmission mediates neuronal iron homeostasis via the GTPase Dexras1 .
26358293	0	iron	51,55	Dexras1	32,39	iron	Dexras1	MESH:D007501	51655	Chemical	Gene	trafficking|compound|START_ENTITY suppresses|dobj|trafficking suppresses|nsubj|phosphorylation phosphorylation|nmod|END_ENTITY	PKA-mediated phosphorylation of Dexras1 suppresses iron trafficking by inhibiting S-nitrosylation .
27080392	0	iron	10,14	Dexras1	77,84	iron	Dexras1	MESH:D007501	19416(Tax:10090)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|excitation excitation|nmod|GTPase GTPase|appos|END_ENTITY	Lysosomal iron modulates NMDA receptor-mediated excitation via small GTPase , Dexras1 .
24850829	0	iron	31,35	Dmt1	26,30	iron	Dmt1	MESH:D007501	24906(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	Influence of cytokines on Dmt1 iron transporter and ferritin expression in insulin-secreting cells .
18492824	0	iron	44,48	Duodenal_cytochrome_B	0,21	iron	Duodenal cytochrome B	MESH:D007501	79901	Chemical	Gene	uptake|compound|START_ENTITY stimulates|dobj|uptake stimulates|nsubj|expression expression|compound|END_ENTITY	Duodenal_cytochrome_B expression stimulates iron uptake by human intestinal epithelial cells .
1125327	0	iron	26,30	Erythropoietin	0,14	iron	Erythropoietin	MESH:D007501	24335(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY effects|nmod|metabolism effects|nsubj|END_ENTITY	Erythropoietin effects on iron metabolism in rat bone marrow cells .
12481145	0	iron	104,108	Erythropoietin	0,14	iron	Erythropoietin	MESH:D007501	2056	Chemical	Gene	need|nmod|START_ENTITY lack|nmod|need therapy|dep|lack therapy|compound|END_ENTITY	Erythropoietin therapy in pre-dialysis patients with chronic_renal_failure : lack of need for parenteral iron .
16540422	0	iron	69,73	Erythropoietin	0,14	iron	Erythropoietin	MESH:D007501	2056	Chemical	Gene	mobilization|nmod|START_ENTITY potentiate|dobj|mobilization potentiate|nsubj|administration administration|compound|END_ENTITY	Erythropoietin administration may potentiate mobilization of storage iron in patients on oral iron chelation therapy .
16540422	0	iron	94,98	Erythropoietin	0,14	iron	Erythropoietin	MESH:D007501	2056	Chemical	Gene	therapy|compound|START_ENTITY patients|nmod|therapy potentiate|nmod|patients potentiate|nsubj|administration administration|compound|END_ENTITY	Erythropoietin administration may potentiate mobilization of storage iron in patients on oral iron chelation therapy .
16917084	0	iron	24,28	Erythropoietin	0,14	iron	Erythropoietin	MESH:D007501	2056	Chemical	Gene	stores|compound|START_ENTITY stores|amod|END_ENTITY	Erythropoietin depletes iron stores : antioxidant neuroprotection for ischemic_stroke ?
17653881	0	iron	31,35	Erythropoietin	0,14	iron	Erythropoietin	MESH:D007501	2056	Chemical	Gene	therapy|compound|START_ENTITY therapy|compound|END_ENTITY	Erythropoietin and intravenous iron therapy in postpartum anaemia .
20631677	0	iron	36,40	Erythropoietin	0,14	iron	Erythropoietin	MESH:D007501	24335(Tax:10116)	Chemical	Gene	absorption|compound|START_ENTITY regulates|dobj|absorption regulates|nsubj|END_ENTITY	Erythropoietin regulates intestinal iron absorption in a rat model of chronic_renal_failure .
3978235	0	iron	70,74	Erythropoietin	0,14	iron	Erythropoietin	MESH:D007501	24335(Tax:10116)	Chemical	Gene	deficiency|compound|START_ENTITY development|nmod|deficiency concentration|nmod|development concentration|compound|END_ENTITY	Erythropoietin concentration during the development and recovery from iron deficiency in the rat .
8723573	0	iron	16,20	Erythropoietin	0,14	iron	Erythropoietin	MESH:D007501	2056	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|appos|metabolism	Erythropoietin , iron metabolism , and red blood cell production .
9804503	0	iron	78,82	Erythropoietin	0,14	iron	Erythropoietin	MESH:D007501	2056	Chemical	Gene	repletion|compound|START_ENTITY remain|nmod|repletion remain|nsubj|requirements requirements|amod|END_ENTITY	Erythropoietin -LRB- EPO -RRB- requirements remain high in EPO resistant patients after iron repletion .
22648410	0	iron	101,105	FBXL5	72,77	iron	FBXL5	MESH:D007501	26234	Chemical	Gene	communicates|dobj|START_ENTITY communicates|nsubj|domain domain|nmod|F-box_and_leucine-rich_repeat_protein_5 F-box_and_leucine-rich_repeat_protein_5|appos|END_ENTITY	Hemerythrin-like domain within F-box_and_leucine-rich_repeat_protein_5 -LRB- FBXL5 -RRB- communicates cellular iron and oxygen availability by distinct mechanisms .
23135277	0	iron	101,105	FBXL5	41,46	iron	FBXL5	MESH:D007501	242960(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY maintenance|nmod|homeostasis required|nmod|maintenance required|nsubjpass|F-box_and_leucine-rich_repeat_protein_5 F-box_and_leucine-rich_repeat_protein_5|appos|END_ENTITY	F-box_and_leucine-rich_repeat_protein_5 -LRB- FBXL5 -RRB- is required for maintenance of cellular and systemic iron homeostasis .
24508277	0	iron	71,75	FBXL5	41,46	iron	FBXL5	MESH:D007501	242960(Tax:10090)	Chemical	Gene	F-box_and_leucine-rich_repeat_protein_5|dep|START_ENTITY F-box_and_leucine-rich_repeat_protein_5|appos|END_ENTITY	F-box_and_leucine-rich_repeat_protein_5 -LRB- FBXL5 -RRB- : sensing intracellular iron and oxygen .
24778179	0	iron	69,73	FBXL5	33,38	iron	FBXL5	MESH:D007501	26234	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	HERC2 targets the iron regulator FBXL5 for degradation and modulates iron metabolism .
18493046	0	iron	105,109	FER1	0,4	iron	FER1	MESH:D007501	5720015(Tax:3055)	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	FER1 and FER2 encoding two ferritin complexes in Chlamydomonas_reinhardtii chloroplasts are regulated by iron .
18024960	0	iron	3,7	FTN-1	32,37	iron	FTN-1	MESH:D007501	179138(Tax:6239)	Chemical	Gene	element|compound|START_ENTITY element|nmod|gene gene|compound|END_ENTITY	An iron enhancer element in the FTN-1 gene directs iron-dependent expression in Caenorhabditis_elegans intestine .
3975573	0	iron	97,101	Ferrochelatase	0,14	iron	Ferrochelatase	MESH:D007501	2235	Chemical	Gene	overload|compound|START_ENTITY deficiency_of_the_bone_marrow|nmod|overload deficiency_of_the_bone_marrow|nsubj|END_ENTITY	Ferrochelatase deficiency_of_the_bone_marrow in a syndrome_of_congenital_microcytic_anaemia with iron overload of the liver and hyperferraemia .
19913091	0	iron	48,52	Ferroportin_1	0,13	iron	Ferroportin 1	MESH:D007501	30061	Chemical	Gene	contributes|xcomp|START_ENTITY contributes|nsubj|END_ENTITY	Ferroportin_1 but not hephaestin contributes to iron accumulation in a cell model of Parkinson 's _ disease .
22170436	0	iron	73,77	Ferroportin_1	0,13	iron	Ferroportin 1	MESH:D007501	30061	Chemical	Gene	treatment|compound|START_ENTITY expression|nmod|treatment expression|compound|END_ENTITY	Ferroportin_1 and hephaestin expression in BeWo cell line with different iron treatment .
14992688	0	iron	10,14	Ftr1p	4,9	iron	Ftr1p	MESH:D007501	856888(Tax:4932)	Chemical	Gene	permease|compound|START_ENTITY permease|amod|END_ENTITY	The Ftr1p iron permease in the yeast plasma membrane : orientation , topology and structure-function relationships .
15053923	0	iron	41,45	GADD153	10,17	iron	GADD153	MESH:D007501	1649	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Increased GADD153 gene expression during iron chelation-induced apoptosis in Jurkat T-lymphocytes .
19120353	0	iron	14,18	GDF15	38,43	iron	GDF15	MESH:D007501	9518	Chemical	Gene	Regulation|nmod|START_ENTITY metabolism|nsubj|Regulation metabolism|nmod|END_ENTITY	Regulation of iron metabolism through GDF15 and hepcidin in pyruvate_kinase_deficiency .
10785444	0	iron	73,77	GDNF	0,4	iron	GDNF	MESH:D007501	25453(Tax:10116)	Chemical	Gene	protect|nmod|START_ENTITY protect|nsubj|END_ENTITY	GDNF and NT-4 protect midbrain dopaminergic neurons from toxic damage by iron and nitric_oxide .
27046124	7	iron	793,797	GPR91	810,815	iron	GPR91	MESH:D007501	84112(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Influence of excess iron and BMP6 on GPR91 expression was investigated in ARPE-19 cells , and wild-type and Hjv - / - pRPE cells .
20175142	0	iron	96,100	H-ferritin	70,80	iron	H-ferritin	MESH:D007501	14319(Tax:10090)	Chemical	Gene	supplementation|compound|START_ENTITY END_ENTITY|nmod|supplementation	Ferritin as a reporter gene for MRI : chronic liver over expression of H-ferritin during dietary iron supplementation and aging .
16221503	0	iron	90,94	HAMP	71,75	iron	HAMP	MESH:D007501	84604(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|interleukin-6 interleukin-6|nmod|END_ENTITY	Regulatory effects of tumor_necrosis_factor-alpha and interleukin-6 on HAMP expression in iron loaded rat hepatocytes .
19787796	0	iron	117,121	HAMP	14,18	iron	HAMP	MESH:D007501	57817	Chemical	Gene	phenotyping|compound|START_ENTITY denaturing|nmod|phenotyping detected|advcl|denaturing TFR2|acl|detected TFR2|appos|END_ENTITY	HFE , SLC40A1 , HAMP , HJV , TFR2 , and FTL mutations detected by denaturing high-performance liquid chromatography after iron phenotyping and HFE C282Y and H63D genotyping in 785 HEIRS Study participants .
23399663	0	iron	33,37	HAMP	78,82	iron	HAMP	MESH:D007501	84604(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY END_ENTITY|nsubj|levels	Dietary fat level affects tissue iron levels but not the iron regulatory gene HAMP in rats .
25276251	0	iron	61,65	HCP1	35,39	iron	HCP1	MESH:D007501	113235	Chemical	Gene	absorption|compound|START_ENTITY role|nmod|absorption role|nmod|END_ENTITY	The role of hepcidin , ferroportin , HCP1 , and DMT1 protein in iron absorption in the human digestive tract .
10085150	0	iron	89,93	HFE	40,43	iron	HFE	MESH:D007501	3077	Chemical	Gene	uptake|compound|START_ENTITY regulates|dobj|uptake regulates|nsubj|protein protein|appos|END_ENTITY	The hereditary_hemochromatosis protein , HFE , specifically regulates transferrin-mediated iron uptake in HeLa cells .
10318901	0	iron	107,111	HFE	76,79	iron	HFE	MESH:D007501	3077	Chemical	Gene	homeostasis|compound|START_ENTITY implications|nmod|homeostasis END_ENTITY|dep|implications	Transferrin_receptor is negatively modulated by the hemochromatosis protein HFE : implications for cellular iron homeostasis .
10572108	0	iron	18,22	HFE	0,3	iron	HFE	MESH:D007501	3077	Chemical	Gene	uptake|compound|START_ENTITY downregulates|dobj|uptake downregulates|nsubj|END_ENTITY	HFE downregulates iron uptake from transferrin and induces iron-regulatory protein activity in stably transfected cells .
10580641	0	iron	103,107	HFE	37,40	iron	HFE	MESH:D007501	3077	Chemical	Gene	regulation|nmod|START_ENTITY functions|nmod|regulation homeostasis|nsubj|functions gene|dep|homeostasis gene|dep|gene gene|appos|END_ENTITY	The hereditary_hemochromatosis gene -LRB- HFE -RRB- : a MHC class I-like gene that functions in the regulation of iron homeostasis .
10910932	0	iron	45,49	HFE	10,13	iron	HFE	MESH:D007501	3077	Chemical	Gene	accumulation|compound|START_ENTITY normalizes|dobj|accumulation normalizes|nsubj|protein protein|compound|END_ENTITY	Wild-type HFE protein normalizes transferrin iron accumulation in macrophages from subjects with hereditary_hemochromatosis .
10925986	0	iron	27,31	HFE	67,70	iron	HFE	MESH:D007501	3077	Chemical	Gene	evaluation|nmod|START_ENTITY evaluation|dep|relationship relationship|nmod|mutations mutations|compound|END_ENTITY	Histological evaluation of iron in liver biopsies : relationship to HFE mutations .
10945226	0	iron	52,56	HFE	45,48	iron	HFE	MESH:D007501	3077	Chemical	Gene	homeostasis|compound|START_ENTITY complex-encoded|nmod|homeostasis complex-encoded|dobj|END_ENTITY	The major histocompatibility complex-encoded HFE in iron homeostasis and immune function .
11078891	0	iron	85,89	HFE	34,37	iron	HFE	MESH:D007501	3077	Chemical	Gene	homeostasis|compound|START_ENTITY critical|nmod|homeostasis critical|nsubj|Interactions Interactions|nmod|ectodomain ectodomain|nmod|END_ENTITY	Interactions of the ectodomain of HFE with the transferrin_receptor are critical for iron homeostasis in cells .
11199371	1	iron	75,79	HFE	133,136	iron	HFE	MESH:D007501	3077	Chemical	Gene	intake|compound|START_ENTITY lead|nsubj|intake lead|nmod|subjects subjects|compound|END_ENTITY	Excessive oral iron intake may lead to secondary hemochromatosis even in HFE C282Y mutation negative subjects .
11313265	12	iron	1554,1558	HFE	1547,1550	iron	TfR	MESH:D007501	7037	Chemical	Gene	uptake|compound|START_ENTITY END_ENTITY|nmod|uptake	The role of HFE in iron uptake by B cells may extend beyond its known interaction with the TfR .
11336795	0	iron	65,69	HFE	36,39	iron	HFE	MESH:D007501	3077	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	The effects of wild-type and mutant HFE expression upon cellular iron uptake in transfected human embryonic kidney cells .
11344112	0	iron	20,24	HFE	0,3	iron	HFE	MESH:D007501	3077	Chemical	Gene	uptake|compound|START_ENTITY inhibits|dobj|uptake inhibits|nsubj|END_ENTITY	HFE inhibits apical iron uptake by intestinal epithelial -LRB- Caco-2 -RRB- cells .
11581431	0	iron	159,163	HFE	74,77	iron	HFE	MESH:D007501	3077	Chemical	Gene	homeostasis|compound|START_ENTITY regulates|dobj|homeostasis molecule|acl:relcl|regulates expression|appos|molecule expression|nmod|END_ENTITY	Human_cytomegalovirus protein US2 interferes with the expression of human HFE , a nonclassical class I major histocompatibility complex molecule that regulates iron homeostasis .
11692063	0	iron	6,10	HFE	64,67	iron	HFE	MESH:D007501	3077	Chemical	Gene	accumulation|compound|START_ENTITY accumulation|nmod|patients patients|nmod|mutations mutations|compound|END_ENTITY	Liver iron accumulation in chronic_hepatitis_C patients without HFE mutations : relationships with histological damage , viral load and genotype and alpha-glutathione_S-transferase levels .
11867720	0	iron	35,39	HFE	50,53	iron	HFE	MESH:D007501	100762132	Chemical	Gene	Regulation|nmod|START_ENTITY uptake|nsubj|Regulation uptake|nmod|END_ENTITY	Regulation of transferrin-mediated iron uptake by HFE , the protein defective in hereditary_hemochromatosis .
11888608	0	iron	15,19	HFE	8,11	iron	HFE	MESH:D007501	3077	Chemical	Gene	metabolism|compound|START_ENTITY Role|nmod|metabolism Role|nmod|END_ENTITY	Role of HFE in iron metabolism , hereditary_haemochromatosis , anaemia_of_chronic_disease , and secondary iron overload .
11981749	0	iron	21,25	HFE	64,67	iron	HFE	MESH:D007501	3077	Chemical	Gene	absorption|compound|START_ENTITY aspects|nmod|absorption aspects|dep|Insights Insights|nmod|role role|nmod|END_ENTITY	Molecular aspects of iron absorption : Insights into the role of HFE in hemochromatosis .
11981749	2	iron	541,545	HFE	498,501	iron	HFE	MESH:D007501	3077	Chemical	Gene	uptake|nmod|START_ENTITY plays|nmod|uptake plays|nsubj|END_ENTITY	HFE , the gene that is defective in the majority of cases , was identified in 1996 and , although the exact role that HFE plays in the uptake and utilization of iron is not yet clear , important aspects of HFE function are emerging .
12064915	0	iron	100,104	HFE	47,50	iron	HFE	MESH:D007501	3077	Chemical	Gene	homeostasis|compound|START_ENTITY disequilibrium|nmod|homeostasis Polymorphisms|dep|disequilibrium Polymorphisms|nmod|region region|nmod|gene gene|compound|END_ENTITY	Polymorphisms in the 5 ' flanking region of the HFE gene : linkage disequilibrium and relationship to iron homeostasis .
12190182	0	iron	12,16	HFE	98,101	iron	HFE	MESH:D007501	3077	Chemical	Gene	capacity|compound|START_ENTITY reliable|nsubj|capacity reliable|nmod|detection detection|nmod|hemochromatosis hemochromatosis|compound|END_ENTITY	Unsaturated iron binding capacity and transferrin saturation are equally reliable in detection of HFE hemochromatosis .
12657433	0	iron	59,63	HFE	51,54	iron	HFE	MESH:D007501	3077	Chemical	Gene	absorption|compound|START_ENTITY role|nmod|absorption role|appos|END_ENTITY	The enigmatic role of the hemochromatosis protein -LRB- HFE -RRB- in iron absorption .
12673276	0	iron	78,82	HFE	46,49	iron	HFE	MESH:D007501	3077	Chemical	Gene	metabolism|compound|START_ENTITY study|nmod|metabolism study|nmod|effect effect|nmod|C282Y C282Y|compound|END_ENTITY	A population-based study of the effect of the HFE C282Y and H63D mutations on iron metabolism .
12737949	0	iron	73,77	HFE	22,25	iron	HFE	MESH:D007501	3077	Chemical	Gene	overload|compound|START_ENTITY potential|nmod|overload mutations|dep|potential mutations|appos|END_ENTITY	Hemochromatosis gene -LRB- HFE -RRB- mutations in South East Asia : a potential for iron overload .
12874382	0	iron	40,44	HFE	81,84	iron	HFE	MESH:D007501	3077	Chemical	Gene	homeostasis|compound|START_ENTITY regulation|nmod|homeostasis Mechanisms|nmod|regulation Mechanisms|dep|Insights Insights|nmod|mutation mutation|compound|END_ENTITY	Mechanisms of HFE-induced regulation of iron homeostasis : Insights from the W81A HFE mutation .
14563638	0	iron	16,20	HFE	73,76	iron	HFE	MESH:D007501	29199(Tax:10116)	Chemical	Gene	mRNAs|compound|START_ENTITY Localization|nmod|mRNAs indicate|nsubj|Localization indicate|ccomp|expressed expressed|nsubjpass|END_ENTITY	Localization of iron metabolism-related mRNAs in rat liver indicate that HFE is expressed predominantly in hepatocytes .
14648375	0	iron	31,35	HFE	0,3	iron	HFE	MESH:D007501	3077	Chemical	Gene	metabolism|compound|START_ENTITY genotype|nmod|metabolism genotype|compound|END_ENTITY	HFE genotype and parameters of iron metabolism in German first-time blood donors - evidence for an increased transferrin_saturation in C282Y heterozygotes .
15044462	0	iron	97,101	HFE	53,56	iron	HFE	MESH:D007501	3077	Chemical	Gene	export|compound|START_ENTITY inhibiting|dobj|export increases|advcl|inhibiting increases|nsubj|Expression Expression|nmod|END_ENTITY	Expression of the hereditary_hemochromatosis protein HFE increases ferritin levels by inhibiting iron export in HT29 cells .
15048869	0	iron	133,137	HFE	83,86	iron	HFE	MESH:D007501	3077	Chemical	Gene	homeostasis|compound|START_ENTITY regulation|nmod|homeostasis sufficient|nmod|regulation sufficient|nsubj|association association|nmod|END_ENTITY	Transferrin -LSB- corrected -RSB- receptor association and endosomal localization of soluble HFE are not sufficient for regulation of cellular iron homeostasis .
15173932	0	iron	59,63	HFE	9,12	iron	HFE	MESH:D007501	15216(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY determine|dobj|homeostasis END_ENTITY|acl:relcl|determine	Duodenal HFE expression and hepcidin levels determine body iron homeostasis : modulation by genetic diversity and dietary iron availability .
15182337	0	iron	75,79	HFE	14,17	iron	HFE	MESH:D007501	3077	Chemical	Gene	loading|compound|START_ENTITY mutations|nmod|loading mutations|nsubj|Prevalence Prevalence|nmod|END_ENTITY	Prevalence of HFE mutations among the Thai population and correlation with iron loading in haemoglobin E disorder .
15528318	0	iron	66,70	HFE	40,43	iron	HFE	MESH:D007501	3077	Chemical	Gene	levels|compound|START_ENTITY lowers|dobj|levels lowers|nsubj|protein protein|appos|END_ENTITY	The hereditary_hemochromatosis protein , HFE , lowers intracellular iron levels independently of transferrin_receptor_1 in TRVb cells .
15538648	0	iron	29,33	HFE	12,15	iron	HFE	MESH:D007501	3077	Chemical	Gene	metabolism|compound|START_ENTITY role|nmod|metabolism role|nmod|mutations mutations|compound|END_ENTITY	The role of HFE mutations on iron metabolism in beta-thalassemia carriers .
15566515	0	iron	8,12	HFE	60,63	iron	HFE	MESH:D007501	3077	Chemical	Gene	loading|compound|START_ENTITY heterozygous|nsubj|loading heterozygous|dobj|mutations mutations|compound|END_ENTITY	Hepatic iron loading in patients with compound heterozygous HFE mutations .
15986199	0	iron	106,110	HFE	37,40	iron	HFE	MESH:D007501	3077	Chemical	Gene	metabolism|compound|START_ENTITY subjects|nmod|metabolism population|nmod|subjects expression|nmod|population expression|nmod|mutations mutations|compound|END_ENTITY	Frequency and clinical expression of HFE gene mutations in a Spanish population of subjects with abnormal iron metabolism .
15991291	0	iron	50,54	HFE	14,17	iron	HFE	MESH:D007501	3077	Chemical	Gene	status|compound|START_ENTITY serum|dobj|status Prevalence|acl|serum Prevalence|nmod|mutations mutations|compound|END_ENTITY	Prevalence of HFE mutations and relation to serum iron status in patients with chronic_hepatitis_C and patients with nonalcoholic_fatty_liver_disease in Taiwan .
16012706	0	iron	71,75	HFE	35,38	iron	HFE	MESH:D007501	3077	Chemical	Gene	increase|dobj|START_ENTITY mutate|xcomp|increase mutate|dobj|END_ENTITY	Do cancer cells selectively mutate HFE to increase their intracellular iron ?
16043695	0	iron	80,84	HFE	53,56	iron	HFE	MESH:D007501	3077	Chemical	Gene	homeostasis|compound|START_ENTITY manipulating|dobj|homeostasis down-regulates|advcl|manipulating down-regulates|dobj|END_ENTITY	HIV-1 Nef down-regulates the hemochromatosis protein HFE , manipulating cellular iron homeostasis .
16105133	0	iron	45,49	HFE	11,14	iron	HFE	MESH:D007501	3077	Chemical	Gene	status|compound|START_ENTITY Effects|nmod|status Effects|nmod|mutations mutations|compound|END_ENTITY	Effects of HFE gene mutations and alcohol on iron status , liver biochemistry and morbidity .
16129824	0	iron	84,88	HFE	40,43	iron	HFE	MESH:D007501	3077	Chemical	Gene	metabolism|compound|START_ENTITY regulates|dobj|metabolism molecule|acl:relcl|regulates Ib|dobj|molecule Ib|nmod|fold fold|dep|recognition recognition|nmod|END_ENTITY	Back to the fold : T cell recognition of HFE , a MHC class Ib molecule that regulates iron metabolism .
16222171	0	iron	59,63	HFE	0,3	iron	HFE	MESH:D007501	3077	Chemical	Gene	status|compound|START_ENTITY intake|nmod|status influence|nmod|intake modifies|dobj|influence modifies|nsubj|genotype genotype|compound|END_ENTITY	HFE genotype modifies the influence of heme_iron intake on iron status .
16240673	0	iron	15,19	HFE	100,103	iron	HFE	MESH:D007501	3077	Chemical	Gene	isotopes|compound|START_ENTITY Measurement|nmod|isotopes Measurement|dep|application application|nmod|study study|nmod|genotypes genotypes|compound|END_ENTITY	Measurement of iron and zinc isotopes in human whole blood : preliminary application to the study of HFE genotypes .
16273299	0	iron	59,63	HFE	0,3	iron	HFE	MESH:D007501	3077	Chemical	Gene	metabolism|compound|START_ENTITY disturbances|nmod|metabolism patients|nmod|disturbances mutations|nmod|patients mutations|compound|END_ENTITY	HFE gene mutations in Polish patients with disturbances of iron metabolism : an initial assessment .
16537971	2	iron	51,55	HFE	18,21	iron	HFE	MESH:D007501	3077	Chemical	Gene	absorption|compound|START_ENTITY END_ENTITY|nmod|absorption	HFE and regulation of intestinal iron absorption .
16629171	0	iron	86,90	HFE	58,61	iron	HFE	MESH:D007501	3077	Chemical	Gene	homeostasis|compound|START_ENTITY regulating|dobj|homeostasis roles|acl|regulating roles|appos|END_ENTITY	Possible roles of the hereditary_hemochromatosis protein , HFE , in regulating cellular iron homeostasis .
16893896	0	iron	126,130	HFE	36,39	iron	HFE	MESH:D007501	3077	Chemical	Gene	sensing|compound|START_ENTITY mechanism|nmod|sensing suggests|dobj|mechanism suggests|advmod|END_ENTITY	Hereditary_hemochromatosis protein , HFE , interaction with transferrin_receptor_2 suggests a molecular mechanism for mammalian iron sensing .
17098454	0	iron	8,12	HFE	52,55	iron	HFE	MESH:D007501	3077	Chemical	Gene	profiles|compound|START_ENTITY profiles|nmod|END_ENTITY	Hepatic iron metabolism gene expression profiles in HFE associated hereditary_hemochromatosis .
17313717	0	iron	110,114	HFE	138,141	iron	HFE	MESH:D007501	3077	Chemical	Gene	status|compound|START_ENTITY status|nmod|men men|acl|carrying carrying|dobj|mutations mutations|compound|END_ENTITY	Serum prohepcidin concentration : no association with iron absorption in healthy men ; and no relationship with iron status in men carrying HFE mutations , hereditary_haemochromatosis patients undergoing phlebotomy treatment , or pregnant women .
17474269	0	iron	35,39	HFE	0,3	iron	HFE	MESH:D007501	3077	Chemical	Gene	risk|nmod|START_ENTITY predicts|dobj|risk predicts|nsubj|H63D H63D|compound|END_ENTITY	HFE mutation H63D predicts risk of iron over load in thalassemia intermedia irrespective of blood transfusions .
17959863	0	iron	89,93	HFE	109,112	iron	HFE	MESH:D007501	3077	Chemical	Gene	reducing|dobj|START_ENTITY reducing|nmod|carriers carriers|nmod|mutations mutations|compound|END_ENTITY	Bloodletting ameliorates insulin sensitivity and secretion in parallel to reducing liver iron in carriers of HFE gene mutations .
18276042	0	iron	14,18	HFE	60,63	iron	HFE	MESH:D007501	3077	Chemical	Gene	absorption|compound|START_ENTITY absorption|dep|comparison comparison|nmod|genotypes genotypes|compound|END_ENTITY	Post-prandial iron absorption in humans : comparison between HFE genotypes and iron deficiency anaemia .
18353247	0	iron	91,95	HFE	0,3	iron	HFE	MESH:D007501	100762132	Chemical	Gene	uptake|nmod|START_ENTITY increases|dobj|uptake increases|nsubj|association association|compound|END_ENTITY	HFE association with transferrin_receptor_2 increases cellular uptake of transferrin-bound iron .
18452683	0	iron	61,65	HFE	99,102	iron	HFE	MESH:D007501	3077	Chemical	Gene	stores|compound|START_ENTITY modifiers|nmod|stores dietary|dobj|modifiers dietary|nmod|mutations mutations|compound|END_ENTITY	Noncitrus fruits as novel dietary environmental modifiers of iron stores in people with or without HFE gene mutations .
18524764	0	iron	54,58	HFE	40,43	iron	HFE	MESH:D007501	3077	Chemical	Gene	uptake|compound|START_ENTITY inhibits|dobj|uptake inhibits|nsubj|protein protein|appos|END_ENTITY	The hereditary_hemochromatosis protein , HFE , inhibits iron uptake via down-regulation of Zip14 in HepG2 cells .
18705322	0	iron	6,10	HFE	67,70	iron	HFE	MESH:D007501	3077	Chemical	Gene	deposits|compound|START_ENTITY serve|nsubj|deposits serve|nmod|marker marker|nmod|mutations mutations|compound|END_ENTITY	Could iron deposits in hepatocytes serve as a prognostic marker of HFE gene mutations ?
19541813	0	iron	37,41	HFE	0,3	iron	HFE	MESH:D007501	3077	Chemical	Gene	effect|nmod|START_ENTITY modulate|dobj|effect modulate|nsubj|mutations mutations|compound|END_ENTITY	HFE mutations modulate the effect of iron on serum hepcidin-25 in chronic hemodialysis patients .
19656448	0	iron	44,48	HFE	0,3	iron	HFE	MESH:D007501	3077	Chemical	Gene	metabolism|compound|START_ENTITY patients|nmod|metabolism mutations|nmod|patients mutations|compound|END_ENTITY	HFE gene mutations in patients with altered iron metabolism in Argentina .
19787796	0	iron	117,121	HFE	0,3	iron	HFE	MESH:D007501	3077	Chemical	Gene	phenotyping|compound|START_ENTITY denaturing|nmod|phenotyping detected|advcl|denaturing TFR2|acl|detected TFR2|compound|END_ENTITY	HFE , SLC40A1 , HAMP , HJV , TFR2 , and FTL mutations detected by denaturing high-performance liquid chromatography after iron phenotyping and HFE C282Y and H63D genotyping in 785 HEIRS Study participants .
20813792	0	iron	6,10	HFE	23,26	iron	HFE	MESH:D007501	3077	Chemical	Gene	parameters|compound|START_ENTITY parameters|appos|genotype genotype|compound|END_ENTITY	Serum iron parameters , HFE C282Y genotype , and cognitive performance in older adults : results from the FACIT study .
21173098	0	iron	38,42	HFE	70,73	iron	HFE	MESH:D007501	3077	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	A time course of hepcidin response to iron challenge in patients with HFE and TFR2 hemochromatosis .
21346098	0	iron	25,29	HFE	0,3	iron	HFE	MESH:D007501	3077	Chemical	Gene	affect|dobj|START_ENTITY affect|nsubj|variants variants|compound|END_ENTITY	HFE gene variants affect iron in the brain .
21346098	7	iron	932,936	HFE	853,856	iron	HFE	MESH:D007501	3077	Chemical	Gene	dyshomeostasis|compound|START_ENTITY associated|nmod|dyshomeostasis associated|nsubjpass|protein protein|compound|END_ENTITY	At the cellular level , the HFE mutant protein resulting from the H63D HFE gene variant is associated with iron dyshomeostasis , increased oxidative stress , glutamate release , tau phosphorylation , and alteration in inflammatory response , each of which is under investigation as a contributing factor to neurodegenerative_diseases .
22118647	0	iron	96,100	HFE	14,17	iron	HFE	MESH:D007501	3077	Chemical	Gene	loss|compound|START_ENTITY repeated|dobj|loss repeated|nsubj|impact impact|nmod|mutations mutations|compound|END_ENTITY	The impact of HFE mutations on haemoglobin and iron status in individuals experiencing repeated iron loss through blood donation * .
22611049	0	iron	45,49	HFE	106,109	iron	HFE	MESH:D007501	3077	Chemical	Gene	parenchymal|dobj|START_ENTITY parenchymal|nmod|mutations mutations|compound|END_ENTITY	Lower serum hepcidin and greater parenchymal iron in nonalcoholic_fatty_liver_disease patients with C282Y HFE mutations .
22773607	0	iron	41,45	HFE	59,62	iron	HFE	MESH:D007501	3077	Chemical	Gene	phenotype|compound|START_ENTITY phenotype|nmod|END_ENTITY	CYBRD1 as a modifier gene that modulates iron phenotype in HFE p.C282Y homozygous patients .
23429074	0	iron	60,64	HFE	18,21	iron	HFE	MESH:D007501	15216(Tax:10090)	Chemical	Gene	profiles|compound|START_ENTITY associated|nmod|profiles associated|nsubjpass|mutation mutation|nmod|gene gene|compound|END_ENTITY	A mutation in the HFE gene is associated with altered brain iron profiles and increased oxidative stress in mice .
23708276	0	iron	4,8	HFE	83,86	iron	HFE	MESH:D007501	3077	Chemical	Gene	index|compound|START_ENTITY index|dep|descriptor descriptor|nmod|hemochromatosis hemochromatosis|compound|END_ENTITY	The iron reabsorption index : a new phenotypic and pathophysiological descriptor in HFE hemochromatosis .
23794717	0	iron	56,60	HFE	35,38	iron	HFE	MESH:D007501	3077	Chemical	Gene	parameters|compound|START_ENTITY variants|nmod|parameters variants|nmod|END_ENTITY	Associations of common variants in HFE and TMPRSS6 with iron parameters are independent of serum hepcidin in a general population : a replication study .
24282517	0	iron	90,94	HFE	135,138	iron	HFE	MESH:D007501	3077	Chemical	Gene	phenotypes|compound|START_ENTITY extended|nmod|phenotypes extended|nmod|patients patients|compound|END_ENTITY	Effects of highly conserved major_histocompatibility_complex -LRB- MHC -RRB- extended haplotypes on iron and low CD8 + T lymphocyte phenotypes in HFE C282Y homozygous hemochromatosis patients from three geographically distant areas .
25085015	0	iron	84,88	HFE	15,18	iron	HFE	MESH:D007501	3077	Chemical	Gene	genes|amod|START_ENTITY Examination|nmod|genes Examination|nmod|associations associations|compound|END_ENTITY	Examination of HFE associations with childhood_leukemia risk and extension to other iron regulatory genes .
25457201	0	iron	78,82	HFE	97,100	iron	HFE	MESH:D007501	3077	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|nmod|hemochromatosis hemochromatosis|compound|END_ENTITY	Genome-wide association study identifies TF as a significant modifier gene of iron metabolism in HFE hemochromatosis .
25687342	0	iron	249,253	HFE	14,17	iron	HFE	MESH:D007501	3077	Chemical	Gene	metabolism|compound|START_ENTITY Study|nmod|metabolism Study|nmod|Genotypes Genotypes|compound|END_ENTITY	`` The Study of HFE Genotypes and its Expression Effect on Iron Status of Iranian Haemochromatosis , Iron_Deficiency_Anemia Patients , Iron-Taker and Non Iron-Taker Controls '' UNASSIGNED : The role of HFE gene mutations or its expression in regulation of iron metabolism of hereditary_haemochromatosis -LRB- HH -RRB- patients is remained controversial .
25740382	0	iron	42,46	HFE	0,3	iron	HFE	MESH:D007501	3077	Chemical	Gene	intake|compound|START_ENTITY influence|nmod|intake hemochromatosis|dep|influence hemochromatosis|compound|END_ENTITY	HFE hemochromatosis : influence of dietary iron intake on the iron overload of C282Y homozygous patients .
25740382	0	iron	61,65	HFE	0,3	iron	HFE	MESH:D007501	3077	Chemical	Gene	overload|compound|START_ENTITY intake|nmod|overload influence|nmod|intake hemochromatosis|dep|influence hemochromatosis|compound|END_ENTITY	HFE hemochromatosis : influence of dietary iron intake on the iron overload of C282Y homozygous patients .
26406355	0	iron	93,97	HFE	73,76	iron	HFE	MESH:D007501	15216(Tax:10090)	Chemical	Gene	phenotype|compound|START_ENTITY impact|nmod|phenotype impact|nmod|deletion deletion|nmod|END_ENTITY	Differing impact of the deletion of hemochromatosis-associated molecules HFE and TFR2 on the iron phenotype of mice lacking BMP6 or HJV .
26992127	0	iron	13,17	HFE	69,72	iron	HFE	MESH:D007501	3077	Chemical	Gene	index|compound|START_ENTITY index|dep|predictor predictor|nmod|haemochromatosis haemochromatosis|compound|END_ENTITY	The modified iron avidity index : A promising phenotypic predictor in HFE haemochromatosis .
9576576	0	iron	76,80	HFE	30,33	iron	HFE	MESH:D007501	3077	Chemical	Gene	assays|compound|START_ENTITY assays|amod|END_ENTITY	Hepatic iron overload : direct HFE -LRB- HLA-H -RRB- mutation analysis vs quantitative iron assays for the diagnosis of hereditary_hemochromatosis .
9576576	0	iron	8,12	HFE	30,33	iron	HFE	MESH:D007501	3077	Chemical	Gene	overload|compound|START_ENTITY overload|dep|assays assays|amod|END_ENTITY	Hepatic iron overload : direct HFE -LRB- HLA-H -RRB- mutation analysis vs quantitative iron assays for the diagnosis of hereditary_hemochromatosis .
9705350	0	iron	150,154	HFE	18,21	iron	HFE	MESH:D007501	3077	Chemical	Gene	regulation|compound|START_ENTITY role|nmod|regulation implies|dobj|role implies|nsubj|Co-trafficking Co-trafficking|nmod|END_ENTITY	Co-trafficking of HFE , a nonclassical major histocompatibility complex class I protein , with the transferrin_receptor implies a role in intracellular iron regulation .
9884584	0	iron	97,101	HFE	48,51	iron	HFE	MESH:D007501	3077	Chemical	Gene	metabolism|compound|START_ENTITY modulates|dobj|metabolism modulates|nsubj|Interaction Interaction|nmod|END_ENTITY	Interaction of the hemochromatosis gene product HFE with transferrin receptor modulates cellular iron metabolism .
9915882	0	iron	59,63	HFE	25,28	iron	HFE	MESH:D007501	3077	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Reciprocal regulation of HFE and NNamp2 gene expression by iron in human intestinal cells .
17168739	0	iron	17,21	HIF-1	8,13	iron	HIF-1	MESH:D007501	3091	Chemical	Gene	regulation|compound|START_ENTITY END_ENTITY|nmod|regulation	Role of HIF-1 in iron regulation : potential therapeutic strategy for neurodegenerative_disorders .
19787796	0	iron	117,121	HJV	20,23	iron	HJV	MESH:D007501	148738	Chemical	Gene	phenotyping|compound|START_ENTITY denaturing|nmod|phenotyping detected|advcl|denaturing TFR2|acl|detected TFR2|appos|END_ENTITY	HFE , SLC40A1 , HAMP , HJV , TFR2 , and FTL mutations detected by denaturing high-performance liquid chromatography after iron phenotyping and HFE C282Y and H63D genotyping in 785 HEIRS Study participants .
15019971	0	iron	115,119	HO-1	132,136	iron	HO-1	MESH:D007501	3162	Chemical	Gene	START_ENTITY|acl|released released|nmod|END_ENTITY	Overexpression of heme_oxygenase _ -LRB- HO -RRB- -1 renders Jurkat T cells resistant to fas-mediated apoptosis : involvement of iron released by HO-1 .
22241739	0	iron	14,18	Hamp	33,37	iron	Hamp	MESH:D007501	84506(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|nmod|END_ENTITY	Regulation of iron metabolism in Hamp -LRB- - / - -RRB- mice in response to iron-deficient diet .
16546437	0	iron	72,76	Heat_shock_protein_27	0,21	iron	Heat shock protein 27	MESH:D007501	3315	Chemical	Gene	uptake|compound|START_ENTITY downregulates|dobj|uptake downregulates|nsubj|END_ENTITY	Heat_shock_protein_27 downregulates the transferrin_receptor_1-mediated iron uptake .
16629181	0	iron	42,46	Heme_oxygenase_1	0,16	iron	Heme oxygenase 1	MESH:D007501	3162	Chemical	Gene	fluxes|compound|START_ENTITY increases|dobj|fluxes increases|nsubj|overexpression overexpression|amod|END_ENTITY	Heme_oxygenase_1 overexpression increases iron fluxes in caco-2 cells .
9380735	0	iron	43,47	Heme_oxygenase_1	0,16	iron	Heme oxygenase 1	MESH:D007501	3162	Chemical	Gene	reutilization|compound|START_ENTITY required|nmod|reutilization required|nsubjpass|END_ENTITY	Heme_oxygenase_1 is required for mammalian iron reutilization .
24860505	0	iron	62,66	Hemojuvelin	0,11	iron	Hemojuvelin	MESH:D007501	148738	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Hemojuvelin and bone_morphogenetic_protein -LRB- BMP -RRB- signaling in iron homeostasis .
11226304	0	iron	47,51	Hfe	68,71	iron	Hfe	MESH:D007501	15216(Tax:10090)	Chemical	Gene	accumulation|compound|START_ENTITY accumulation|nmod|model model|compound|END_ENTITY	Mouse_strain differences determine severity of iron accumulation in Hfe knockout model of hereditary_hemochromatosis .
12149232	0	iron	14,18	Hfe	33,36	iron	Hfe	MESH:D007501	15216(Tax:10090)	Chemical	Gene	absorption|compound|START_ENTITY Regulation|nmod|absorption Regulation|nmod|mice mice|compound|END_ENTITY	Regulation of iron absorption in Hfe mutant mice .
14510961	0	iron	20,24	Hfe	59,62	iron	Hfe	MESH:D007501	15216(Tax:10090)	Chemical	Gene	absorption|compound|START_ENTITY response|nmod|absorption affected|nsubjpass|response affected|nmod|knock-out knock-out|compound|END_ENTITY	Hypoxic response of iron absorption is not affected by the Hfe gene knock-out in mice .
15155457	0	iron	21,25	Hfe	68,71	iron	Hfe	MESH:D007501	15216(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY increased|nsubjpass|uptake increased|nmod|model model|compound|END_ENTITY	Nontransferrin-bound iron uptake by hepatocytes is increased in the Hfe knockout mouse model of hereditary_hemochromatosis .
16271796	0	iron	8,12	Hfe	78,81	iron	Hfe	MESH:D007501	15216(Tax:10090)	Chemical	Gene	export|compound|START_ENTITY contributes|nsubj|export contributes|nmod|iron-loading iron-loading|nmod|mouse mouse|compound|END_ENTITY	Limited iron export by hepatocytes contributes to hepatic iron-loading in the Hfe knockout mouse .
16565419	0	iron	70,74	Hfe	26,29	iron	Hfe	MESH:D007501	15216(Tax:10090)	Chemical	Gene	overload|compound|START_ENTITY requirements|nmod|overload requirements|nmod|END_ENTITY	Distinct requirements for Hfe in basal and induced hepcidin levels in iron overload and inflammation .
16875497	0	iron	77,81	Hfe	26,29	iron	Hfe	MESH:D007501	15216(Tax:10090)	Chemical	Gene	status|compound|START_ENTITY age|nmod|status progression|nmod|age progression|nsubj|study study|nmod|END_ENTITY	Comparative study between Hfe - / - and beta2m - / - mice : progression with age of iron status and liver pathology .
17945001	0	iron	107,111	Hfe	177,180	iron	Hfe	MESH:D007501	15216(Tax:10090)	Chemical	Gene	loading|compound|START_ENTITY susceptibilities|nmod|loading strains|nmod|susceptibilities liver|nmod|strains /|dep|liver /|dep|identification identification|nmod|targets targets|nmod|modifiers modifiers|compound|END_ENTITY	Gene expression profiling of Hfe - / - liver and duodenum in mouse strains with differing susceptibilities to iron loading : identification of transcriptional regulatory targets of Hfe and potential hemochromatosis modifiers .
17945001	0	iron	107,111	Hfe	29,32	iron	Hfe	MESH:D007501	15216(Tax:10090)	Chemical	Gene	loading|compound|START_ENTITY susceptibilities|nmod|loading strains|nmod|susceptibilities liver|nmod|strains /|dep|liver profiling|dep|/ profiling|nmod|END_ENTITY	Gene expression profiling of Hfe - / - liver and duodenum in mouse strains with differing susceptibilities to iron loading : identification of transcriptional regulatory targets of Hfe and potential hemochromatosis modifiers .
20110460	0	iron	31,35	Hfe	50,53	iron	Hfe	MESH:D007501	15216(Tax:10090)	Chemical	Gene	stores|compound|START_ENTITY stores|nmod|mouse mouse|amod|END_ENTITY	Hemochromatosis and pregnancy : iron stores in the Hfe - / - mouse are not reduced by multiple_pregnancies .
20456487	0	iron	52,56	Hfe	22,25	iron	Hfe	MESH:D007501	15216(Tax:10090)	Chemical	Gene	diminishes|dobj|START_ENTITY diminishes|nsubj|treatment treatment|nmod|mice mice|amod|END_ENTITY	Hepcidin treatment in Hfe - / - mice diminishes plasma iron without affecting erythropoiesis .
21059897	0	iron	95,99	Hfe	60,63	iron	Hfe	MESH:D007501	15216(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY modulation|nmod|homeostasis indicates|nmod|modulation indicates|dobj|role role|nmod|END_ENTITY	Enhanced erythropoiesis in Hfe-KO mice indicates a role for Hfe in the modulation of erythroid iron homeostasis .
22180422	0	iron	6,10	Hfe	54,57	iron	Hfe	MESH:D007501	3077	Chemical	Gene	levels|compound|START_ENTITY regulated|nsubjpass|levels regulated|nmod|genotype genotype|compound|END_ENTITY	Fetal iron levels are regulated by maternal and fetal Hfe genotype and dietary iron .
22370144	0	iron	73,77	Hfe	41,44	iron	Hfe	MESH:D007501	15216(Tax:10090)	Chemical	Gene	loading|compound|START_ENTITY model|nmod|loading model|compound|END_ENTITY	Brain transcriptome perturbations in the Hfe -LRB- - / - -RRB- mouse model of genetic iron loading .
25609138	0	iron	46,50	Hfe	0,3	iron	Hfe	MESH:D007501	15216(Tax:10090)	Chemical	Gene	exhibit|nmod|START_ENTITY exhibit|nsubj|END_ENTITY	Hfe and Hjv exhibit overlapping functions for iron signaling to hepcidin .
9660756	0	iron	59,63	Hypoxia-inducible_factor_1alpha	0,31	iron	Hypoxia-inducible factor 1alpha	MESH:D007501	3091	Chemical	Gene	protein|compound|START_ENTITY protein|nsubj|END_ENTITY	Hypoxia-inducible_factor_1alpha -LRB- HIF-1alpha -RRB- is a non-heme iron protein .
16880998	0	iron	78,82	Hypoxia-inducible_factor_prolyl_hydroxylase_2	0,45	iron	Hypoxia-inducible factor prolyl hydroxylase 2	MESH:D007501	54583	Chemical	Gene	affinity|nmod|START_ENTITY has|dobj|affinity has|nsubj|END_ENTITY	Hypoxia-inducible_factor_prolyl_hydroxylase_2 has a high affinity for ferrous iron and 2-oxoglutarate .
24184387	0	iron	37,41	Hypoxia_inducible_factor-1a	0,27	iron	Hypoxia inducible factor-1a	MESH:D007501	3091	Chemical	Gene	uptake|compound|START_ENTITY mediates|dobj|uptake mediates|nsubj|END_ENTITY	Hypoxia_inducible_factor-1a mediates iron uptake which induces inflammatory response in amoeboid microglial cells in developing periventricular white matter through MAP kinase pathway .
7533289	1	iron	227,231	IRP	188,191	iron	IRP	MESH:D007501	22413(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY regulator|nmod|homeostasis regulator|nsubj|Iron-regulatory_protein Iron-regulatory_protein|appos|END_ENTITY	Iron-regulatory_protein -LRB- IRP -RRB- is a master regulator of cellular iron homeostasis .
7585245	0	iron	61,65	IRP	86,89	iron	IRP	MESH:D007501	7472	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Differential regulation of two related RNA-binding proteins , iron regulatory protein -LRB- IRP -RRB- and IRPB .
8836047	1	iron	149,153	IRP	223,226	iron	IRP	MESH:D007501	7472	Chemical	Gene	homeostasis|compound|START_ENTITY regulated|nsubjpass|homeostasis regulated|nmod|iron_regulatory_protein iron_regulatory_protein|appos|END_ENTITY	Cellular iron homeostasis is regulated by the cytoplasmic iron_regulatory_protein -LRB- IRP -RRB- , which binds to iron-responsive elements -LRB- IRE -RRB- of mRNAs , modulating iron uptake and sequestration , respectively .
9338146	0	iron	38,42	IRP	113,116	iron	IRP	MESH:D007501	7472	Chemical	Gene	grow|nmod|START_ENTITY cells|acl|grow inability|nmod|cells correlates|nsubj|inability correlates|nmod|activity activity|nmod|protein protein|appos|END_ENTITY	The inability of cells to grow in low iron correlates with increasing activity of their iron regulatory protein -LRB- IRP -RRB- .
9338146	0	iron	88,92	IRP	113,116	iron	IRP	MESH:D007501	7472	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	The inability of cells to grow in low iron correlates with increasing activity of their iron regulatory protein -LRB- IRP -RRB- .
18694996	0	iron	25,29	IRP-2	60,65	iron	IRP-2	MESH:D007501	64602(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|cells cells|nmod|END_ENTITY	Stat5 regulates cellular iron uptake of erythroid cells via IRP-2 and TfR-1 .
10805735	0	iron	50,54	ISA1	33,37	iron	ISA1	MESH:D007501	850632(Tax:4932)	Chemical	Gene	homeostasis|compound|START_ENTITY Role|nmod|homeostasis Role|nmod|END_ENTITY	Role of Saccharomyces_cerevisiae ISA1 and ISA2 in iron homeostasis .
10881887	0	iron	20,24	Insulin	0,7	iron	Insulin	MESH:D007501	3630	Chemical	Gene	resistance|appos|START_ENTITY resistance|compound|END_ENTITY	Insulin resistance , iron , and the liver .
15172111	0	iron	31,35	Interleukin-1beta	0,17	iron	Interleukin-1beta	MESH:D007501	24494(Tax:10116)	Chemical	Gene	efflux|compound|START_ENTITY efflux|amod|END_ENTITY	Interleukin-1beta up-regulates iron efflux in rat C6 glioma cells through modulation of ceruloplasmin and ferroportin-1 synthesis .
9380695	0	iron	112,116	Iron_regulatory_protein_1	0,25	iron	Iron regulatory protein 1	MESH:D007501	11428(Tax:10090)	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Iron_regulatory_protein_1 is not required for the modulation of ferritin and transferrin_receptor expression by iron in a murine pro-B lymphocyte cell line .
12591920	0	iron	29,33	Iron_regulatory_protein_2	0,25	iron	Iron regulatory protein 2	MESH:D007501	3658	Chemical	Gene	sensor|compound|START_ENTITY END_ENTITY|nmod|sensor	Iron_regulatory_protein_2 as iron sensor .
15222466	0	iron	21,25	Lactoferrin	0,11	iron	Lactoferrin	MESH:D007501	17002(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY role|nmod|homeostasis END_ENTITY|dep|role	Lactoferrin : role in iron homeostasis and host defense against microbial_infection .
20646353	0	iron	54,58	Lactoferrin	0,11	iron	Lactoferrin	MESH:D007501	280846(Tax:9913)	Chemical	Gene	disorders|compound|START_ENTITY curing|dobj|disorders ferrous_sulfate|advcl|curing versus|xcomp|ferrous_sulfate versus|nsubj|END_ENTITY	Lactoferrin efficacy versus ferrous_sulfate in curing iron disorders in pregnant and non-pregnant women .
24571258	0	iron	55,59	Lactoferrin	0,11	iron	Lactoferrin	MESH:D007501	4057	Chemical	Gene	leads|xcomp|START_ENTITY leads|nsubj|knockdown knockdown|compound|END_ENTITY	Lactoferrin gene knockdown leads to similar effects to iron chelation in human adipocytes .
8430794	0	iron	38,42	Lactoferrin	0,11	iron	Lactoferrin	MESH:D007501	301034(Tax:10116)	Chemical	Gene	uptake|nmod|START_ENTITY interferes|nmod|uptake interferes|nsubj|END_ENTITY	Lactoferrin interferes with uptake of iron from transferrin and asialotransferrin by the rat liver .
24750026	0	iron	15,19	MBD5	0,4	iron	MBD5	MESH:D007501	109241(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY regulates|dobj|metabolism regulates|nsubj|END_ENTITY	MBD5 regulates iron metabolism via methylation-independent genomic targeting of Fth1 through KAT2A in mice .
11734214	0	iron	44,48	Manganese_superoxide_dismutase	0,30	iron	Manganese superoxide dismutase	MESH:D007501	6648	Chemical	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Manganese_superoxide_dismutase induction by iron is impaired in Friedreich_ataxia cells .
23219873	0	iron	85,89	Manganese_superoxide_dismutase	0,30	iron	Manganese superoxide dismutase	MESH:D007501	20656(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY perturbs|dobj|homeostasis perturbs|nsubj|depletion depletion|amod|END_ENTITY	Manganese_superoxide_dismutase depletion in murine hematopoietic stem cells perturbs iron homeostasis , globin switching , and epigenetic control in erythrocyte precursor cells .
19377077	0	iron	51,55	Matriptase-2	0,12	iron	Matriptase-2	MESH:D007501	164656	Chemical	Gene	homeostasis|compound|START_ENTITY regulator|nmod|homeostasis END_ENTITY|dep|regulator	Matriptase-2 -LRB- TMPRSS6 -RRB- : a proteolytic regulator of iron homeostasis .
23016685	0	iron	39,43	Matriptase-2	0,12	iron	Matriptase-2	MESH:D007501	71753(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY protease|nmod|homeostasis END_ENTITY|appos|protease	Matriptase-2 , a regulatory protease of iron homeostasis : possible substrates , cleavage sites and inhibitors .
24904115	0	iron	114,118	Matriptase-2	0,12	iron	Matriptase-2	MESH:D007501	71753(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY maintain|dobj|homeostasis essential|xcomp|maintain essential|nsubj|END_ENTITY	Matriptase-2 is essential for hepcidin repression during fetal life and postnatal development in mice to maintain iron homeostasis .
12547228	0	iron	40,44	Mitochondrial_ferritin	0,22	iron	Mitochondrial ferritin	MESH:D007501	94033	Chemical	Gene	metabolism|compound|START_ENTITY player|nmod|metabolism END_ENTITY|dep|player	Mitochondrial_ferritin : a new player in iron metabolism .
18815198	0	iron	72,76	Mitochondrial_ferritin	0,22	iron	Mitochondrial ferritin	MESH:D007501	94033	Chemical	Gene	availability|compound|START_ENTITY regulating|dobj|availability damage|acl|regulating limits|dobj|damage limits|nsubj|END_ENTITY	Mitochondrial_ferritin limits oxidative damage regulating mitochondrial iron availability : hypothesis for a protective role in Friedreich_ataxia .
24596558	0	iron	50,54	Mitochondrial_ferritin	0,22	iron	Mitochondrial ferritin	MESH:D007501	94033	Chemical	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Mitochondrial_ferritin in the regulation of brain iron homeostasis and neurodegenerative_diseases .
24798331	0	iron	103,107	Mmt1	54,58	iron	Mmt1	MESH:D007501	855215(Tax:4932)	Chemical	Gene	homeostasis|compound|START_ENTITY affects|dobj|homeostasis affects|nsubj|END_ENTITY	Expression of the yeast cation diffusion facilitators Mmt1 and Mmt2 affects mitochondrial and cellular iron homeostasis : evidence for mitochondrial iron export .
22847425	0	iron	53,57	Multicopper_oxidase-1	0,21	iron	Multicopper oxidase-1	MESH:D007501	34258(Tax:7227)	Chemical	Gene	homeostasis|compound|START_ENTITY essential|nmod|homeostasis essential|nsubj|END_ENTITY	Multicopper_oxidase-1 is a ferroxidase essential for iron homeostasis in Drosophila_melanogaster .
22820082	0	iron	25,29	Myeloperoxidase	0,15	iron	Myeloperoxidase	MESH:D007501	4353	Chemical	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	Myeloperoxidase and free iron levels : potential biomarkers for early detection and prognosis of ovarian_cancer .
23624305	0	iron	41,45	Myeloperoxidase	0,15	iron	Myeloperoxidase	MESH:D007501	4353	Chemical	Gene	source|nmod|START_ENTITY acts|nmod|source acts|nsubj|END_ENTITY	Myeloperoxidase acts as a source of free iron during steady-state catalysis by a feedback inhibitory pathway .
10769179	0	iron	51,55	NRAMP1	15,21	iron	NRAMP1	MESH:D007501	844422(Tax:3702)	Chemical	Gene	transport|compound|START_ENTITY Involvement|nmod|transport Involvement|nmod|END_ENTITY	Involvement of NRAMP1 from Arabidopsis_thaliana in iron transport .
11358358	0	iron	42,46	NRAMP1	16,22	iron	NRAMP1	MESH:D007501	6556	Chemical	Gene	transport|compound|START_ENTITY implicated|nmod|transport gene|acl|implicated gene|compound|END_ENTITY	Analysis of the NRAMP1 gene implicated in iron transport : association with multiple_sclerosis and age effects .
19549696	0	iron	59,63	Neutrophil_gelatinase-associated_lipocalin	0,42	iron	Neutrophil gelatinase-associated lipocalin	MESH:D007501	3934	Chemical	Gene	status|compound|START_ENTITY reflects|dobj|status reflects|nsubj|END_ENTITY	Neutrophil_gelatinase-associated_lipocalin -LRB- NGAL -RRB- reflects iron status in haemodialysis patients .
20086155	0	iron	132,136	Neutrophil_gelatinase-associated_lipocalin	0,42	iron	Neutrophil gelatinase-associated lipocalin	MESH:D007501	3934	Chemical	Gene	acquisition|compound|START_ENTITY interfering|nmod|acquisition expresses|advcl|interfering expresses|nsubj|END_ENTITY	Neutrophil_gelatinase-associated_lipocalin expresses antimicrobial activity by interfering with L-norepinephrine-mediated bacterial iron acquisition .
10577506	0	iron	37,41	Nramp1	0,6	iron	Nramp1	MESH:D007501	18173(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY link|nmod|transport END_ENTITY|dep|link	Nramp1 : a link between intracellular iron transport and innate resistance to intracellular pathogens .
11449359	0	iron	17,21	Nramp1	0,6	iron	Nramp1	MESH:D007501	6556	Chemical	Gene	homoeostasis|compound|START_ENTITY modulates|dobj|homoeostasis modulates|nsubj|END_ENTITY	Nramp1 modulates iron homoeostasis in vivo and in vitro : evidence for a role in cellular iron release involving de-acidification of intracellular vesicles .
11903051	0	iron	151,155	Nramp1	39,45	iron	Nramp1	MESH:D007501	6556	Chemical	Gene	uptake|compound|START_ENTITY acquired|nmod|uptake iron|acl|acquired metabolism|nmod|iron regulates|dobj|metabolism regulates|nsubj|Solute_carrier_11a1 Solute_carrier_11a1|dep|Slc11a1 Slc11a1|dep|END_ENTITY	Solute_carrier_11a1 -LRB- Slc11a1 ; formerly Nramp1 -RRB- regulates metabolism and release of iron acquired by phagocytic , but not transferrin-receptor-mediated , iron uptake .
11903051	0	iron	83,87	Nramp1	39,45	iron	Nramp1	MESH:D007501	6556	Chemical	Gene	metabolism|nmod|START_ENTITY regulates|dobj|metabolism regulates|nsubj|Solute_carrier_11a1 Solute_carrier_11a1|dep|Slc11a1 Slc11a1|dep|END_ENTITY	Solute_carrier_11a1 -LRB- Slc11a1 ; formerly Nramp1 -RRB- regulates metabolism and release of iron acquired by phagocytic , but not transferrin-receptor-mediated , iron uptake .
18086376	0	iron	25,29	Nramp1	43,49	iron	Nramp1	MESH:D007501	18173(Tax:10090)	Chemical	Gene	Modulation|nmod|START_ENTITY transport|nsubj|Modulation transport|nmod|END_ENTITY	Modulation of macrophage iron transport by Nramp1 -LRB- Slc11a1 -RRB- .
18191835	0	iron	26,30	Nramp1	43,49	iron	Nramp1	MESH:D007501	18173(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY transporter|nsubj|expression transporter|dobj|END_ENTITY	Altered expression of the iron transporter Nramp1 -LRB- Slc11a1 -RRB- during fetal development of the retinal_pigment_epithelium in microphthalmia-associated_transcription_factor Mitf -LRB- mi -RRB- and Mitf -LRB- vitiligo -RRB- mouse mutants .
18456389	0	iron	40,44	Nramp1	0,6	iron	Nramp1	MESH:D007501	6556	Chemical	Gene	macrophages|nmod|START_ENTITY equips|dobj|macrophages equips|nsubj|END_ENTITY	Nramp1 equips macrophages for efficient iron recycling .
19321419	0	iron	50,54	Nramp1	0,6	iron	Nramp1	MESH:D007501	18173(Tax:10090)	Chemical	Gene	recycling|nmod|START_ENTITY promotes|dobj|recycling promotes|nsubj|END_ENTITY	Nramp1 promotes efficient macrophage recycling of iron following erythrophagocytosis in vivo .
20394798	0	iron	60,64	Nramp1	5,11	iron	Nramp1	MESH:D007501	6556	Chemical	Gene	recycling|compound|START_ENTITY necessary|nmod|recycling necessary|nsubj|END_ENTITY	Both Nramp1 and DMT1 are necessary for efficient macrophage iron recycling .
22508410	0	iron	66,70	Nramp1	90,96	iron	Nramp1	MESH:D007501	6556	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	High levels of tumor_necrosis_factor-a downregulate antimicrobial iron transport protein , Nramp1 , in chronic hemodialysis patients : a key factor for infection risk .
9559656	0	iron	54,58	Nramp1	22,28	iron	Nramp1	MESH:D007501	6556	Chemical	Gene	accumulation|compound|START_ENTITY modulates|dobj|accumulation modulates|nsubj|expression expression|nmod|END_ENTITY	Ectopic expression of Nramp1 in COS-1 cells modulates iron accumulation .
10429185	0	iron	28,32	Nramp2	72,78	iron	Nramp2	MESH:D007501	18174(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	The effect of intracellular iron concentration and nitrogen_monoxide on Nramp2 expression and non-transferrin-bound iron uptake .
10625641	0	iron	50,54	Nramp2	0,6	iron	Nramp2	MESH:D007501	4891	Chemical	Gene	uptake|compound|START_ENTITY associated|nmod|uptake associated|nsubjpass|expression expression|amod|END_ENTITY	Nramp2 expression is associated with pH-dependent iron uptake across the apical membrane of human intestinal Caco-2 cells .
9241278	0	iron	63,67	Nramp2	43,49	iron	Nramp2	MESH:D007501	18174(Tax:10090)	Chemical	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	Microcytic_anaemia mice have a mutation in Nramp2 , a candidate iron transporter gene .
9448300	0	iron	93,97	Nramp2	0,6	iron	Nramp2	MESH:D007501	25715(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY Nramp2|nmod|transport role|nmod|Nramp2 evidence|nmod|role rat|dep|evidence mutated|nmod|rat mutated|nsubjpass|END_ENTITY	Nramp2 is mutated in the anemic Belgrade -LRB- b -RRB- rat : evidence of a role for Nramp2 in endosomal iron transport .
9448300	0	iron	93,97	Nramp2	73,79	iron	Nramp2	MESH:D007501	25715(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|nmod|transport	Nramp2 is mutated in the anemic Belgrade -LRB- b -RRB- rat : evidence of a role for Nramp2 in endosomal iron transport .
9564183	0	iron	31,35	Nramp2	18,24	iron	Nramp2	MESH:D007501	4891	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|nmod|protein	Identification of Nramp2 as an iron transport protein : another piece of the intestinal iron absorption puzzle .
9564183	0	iron	87,91	Nramp2	18,24	iron	Nramp2	MESH:D007501	4891	Chemical	Gene	puzzle|compound|START_ENTITY piece|nmod|puzzle Identification|dep|piece Identification|nmod|END_ENTITY	Identification of Nramp2 as an iron transport protein : another piece of the intestinal iron absorption puzzle .
21303654	0	iron	38,42	Nrf2	0,4	iron	Nrf2	MESH:D007501	18024(Tax:10090)	Chemical	Gene	efflux|compound|START_ENTITY regulates|dobj|efflux regulates|nsubj|END_ENTITY	Nrf2 regulates ferroportin_1-mediated iron efflux and counteracts lipopolysaccharide-induced ferroportin_1 mRNA suppression in macrophages .
22367278	0	iron	22,26	Nrf2	0,4	iron	Nrf2	MESH:D007501	18024(Tax:10090)	Chemical	Gene	accumulation|compound|START_ENTITY inhibits|dobj|accumulation inhibits|nsubj|END_ENTITY	Nrf2 inhibits hepatic iron accumulation and counteracts oxidative stress-induced liver_injury in nutritional steatohepatitis .
26546695	0	iron	89,93	Nrf2	47,51	iron	Nrf2	MESH:D007501	4780	Chemical	Gene	absorption|compound|START_ENTITY control|nmod|absorption Implications|nmod|control END_ENTITY|dep|Implications	Phytoestrogens modulate hepcidin expression by Nrf2 : Implications for dietary control of iron absorption .
1903535	0	iron	31,35	P-90	92,96	iron	P-90	MESH:D007501	7037	Chemical	Gene	element|compound|START_ENTITY element|nmod|END_ENTITY	Ferritin mRNA : interactions of iron regulatory element with translational regulator protein P-90 and the effect on base-paired flanking regions .
17337631	0	iron	64,68	PIC1	0,4	iron	PIC1	MESH:D007501	816018(Tax:3702)	Chemical	Gene	transport|compound|START_ENTITY mediates|dobj|transport mediates|nsubj|END_ENTITY	PIC1 , an ancient permease in Arabidopsis chloroplasts , mediates iron transport .
19568430	0	iron	48,52	PrP	15,18	iron	PrP	MESH:D007501	19122(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY show|dobj|metabolism show|nsubj|mice mice|appos|END_ENTITY	Prion_protein -LRB- PrP -RRB- knock-out mice show altered iron metabolism : a functional role for PrP in iron uptake and transport .
19568430	0	iron	48,52	PrP	87,90	iron	PrP	MESH:D007501	19122(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|dep|role role|nmod|END_ENTITY	Prion_protein -LRB- PrP -RRB- knock-out mice show altered iron metabolism : a functional role for PrP in iron uptake and transport .
19568430	0	iron	94,98	PrP	15,18	iron	PrP	MESH:D007501	19122(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY PrP|nmod|uptake role|nmod|PrP metabolism|dep|role show|dobj|metabolism show|nsubj|mice mice|appos|END_ENTITY	Prion_protein -LRB- PrP -RRB- knock-out mice show altered iron metabolism : a functional role for PrP in iron uptake and transport .
19568430	0	iron	94,98	PrP	87,90	iron	PrP	MESH:D007501	19122(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY END_ENTITY|nmod|uptake	Prion_protein -LRB- PrP -RRB- knock-out mice show altered iron metabolism : a functional role for PrP in iron uptake and transport .
19212444	0	iron	33,37	Prion_protein	0,13	iron	Prion protein	MESH:D007501	5621	Chemical	Gene	uptake|compound|START_ENTITY modulates|dobj|uptake modulates|nsubj|END_ENTITY	Prion_protein modulates cellular iron uptake : a novel function with implications for prion disease pathogenesis .
23478311	0	iron	24,28	Prion_protein	0,13	iron	Prion protein	MESH:D007501	19122(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY regulates|dobj|transport regulates|nsubj|END_ENTITY	Prion_protein regulates iron transport by functioning as a ferrireductase .
19000728	0	iron	19,23	Rg1	0,3	iron	Rg1	MESH:D007501	140491(Tax:10090)	Chemical	Gene	levels|compound|START_ENTITY reduces|dobj|levels reduces|nsubj|END_ENTITY	Rg1 reduces nigral iron levels of MPTP-treated C57BL6 mice by regulating certain iron transport proteins .
24909164	0	iron	25,29	SIRT3	0,5	iron	SIRT3	MESH:D007501	23410	Chemical	Gene	metabolism|compound|START_ENTITY regulates|dobj|metabolism regulates|nsubj|END_ENTITY	SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron_regulatory_protein_1 .
24909164	0	iron	25,29	SIRT3	0,5	iron	SIRT3	MESH:D007501	23410	Chemical	Gene	metabolism|compound|START_ENTITY regulates|dobj|metabolism regulates|nsubj|END_ENTITY	SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron_regulatory_protein_1 .
21871825	0	iron	157,161	SLC11A2	36,43	iron	SLC11A2	MESH:D007501	4891	Chemical	Gene	overload|compound|START_ENTITY leads|nmod|overload leads|nsubj|mutation mutation|nmod|trafficking trafficking|compound|END_ENTITY	A novel N491S mutation in the human SLC11A2 gene impairs protein trafficking and in association with the G212V mutation leads to microcytic_anemia and liver iron overload .
19787796	0	iron	117,121	SLC40A1	5,12	iron	SLC40A1	MESH:D007501	30061	Chemical	Gene	phenotyping|compound|START_ENTITY denaturing|nmod|phenotyping detected|advcl|denaturing TFR2|acl|detected TFR2|appos|END_ENTITY	HFE , SLC40A1 , HAMP , HJV , TFR2 , and FTL mutations detected by denaturing high-performance liquid chromatography after iron phenotyping and HFE C282Y and H63D genotyping in 785 HEIRS Study participants .
16330325	0	iron	19,23	SMAD4	10,15	iron	SMAD4	MESH:D007501	4089	Chemical	Gene	metabolism|compound|START_ENTITY role|nmod|metabolism role|nmod|END_ENTITY	A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression .
16475818	0	iron	67,71	Slc11A2	98,105	iron	Slc11A2	MESH:D007501	733595(Tax:9823)	Chemical	Gene	DMT1|compound|START_ENTITY DMT1|appos|NRAMP2 NRAMP2|dep|END_ENTITY	Distinct targeting and recycling properties of two isoforms of the iron transporter DMT1 -LRB- NRAMP2 , Slc11A2 -RRB- .
15849611	0	iron	35,39	Slc11a2	0,7	iron	Slc11a2	MESH:D007501	18174(Tax:10090)	Chemical	Gene	absorption|compound|START_ENTITY required|nmod|absorption required|nsubjpass|END_ENTITY	Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver .
19621945	0	iron	48,52	Slc11a2	40,47	iron	Slc11a2	MESH:D007501	4891	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	Transmembrane topology of the mammalian Slc11a2 iron transporter .
23743663	0	iron	25,29	Spin	0,4	iron	Spin	MESH:D007501	10927	Chemical	Gene	modulation|nmod|START_ENTITY modulation|compound|END_ENTITY	Spin state modulation of iron spin crossover complexes via hydrogen-bonding self-assembly .
18694996	0	iron	25,29	Stat5	0,5	iron	Stat5	MESH:D007501	20850(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY regulates|dobj|uptake regulates|nsubj|END_ENTITY	Stat5 regulates cellular iron uptake of erythroid cells via IRP-2 and TfR-1 .
24847265	0	iron	33,37	TFR2	25,29	iron	TFR2	MESH:D007501	50765(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY role|nmod|homeostasis role|nmod|END_ENTITY	The extrahepatic role of TFR2 in iron homeostasis .
15731565	0	iron	23,27	TGF-beta1	31,40	iron	TGF-beta1	MESH:D007501	7040	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|production production|compound|END_ENTITY	Suppressive effects of iron on TGF-beta1 production by renal proximal tubular epithelial cells .
24661031	0	iron	59,63	TMPRSS6	32,39	iron	TMPRSS6	MESH:D007501	164656	Chemical	Gene	deficiency|compound|START_ENTITY END_ENTITY|nmod|deficiency	A novel tri-allelic mutation of TMPRSS6 in iron-refractory iron deficiency anaemia with response to glucocorticoid .
18794901	0	iron	72,76	TRPML1	45,51	iron	TRPML1	MESH:D007501	57192	Chemical	Gene	channel|compound|START_ENTITY channel|nsubj|END_ENTITY	The type_IV_mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel .
15140607	0	iron	44,48	Thy1	0,4	iron	Thy1	MESH:D007501	24832(Tax:10116)	Chemical	Gene	affected|nmod|START_ENTITY affected|nsubjpass|expression expression|amod|END_ENTITY	Thy1 expression in the brain is affected by iron and is decreased in Restless_Legs_Syndrome .
10329956	0	iron	23,27	Transferrin	0,11	iron	Transferrin	MESH:D007501	7018	Chemical	Gene	absorption|compound|START_ENTITY stimulates|dobj|absorption stimulates|nsubj|END_ENTITY	Transferrin stimulates iron absorption , exocytosis , and secretion in cultured intestinal cells .
1052027	0	iron	40,44	Transferrin	0,11	iron	Transferrin	MESH:D007501	7018	Chemical	Gene	transport|compound|START_ENTITY physiology|nmod|transport END_ENTITY|dep|physiology	Transferrin : physiology and function in iron transport .
10547300	0	iron	85,89	Transferrin	0,11	iron	Transferrin	MESH:D007501	7018	Chemical	Gene	uptake|compound|START_ENTITY mechanism|nmod|uptake involved|nmod|mechanism complex|acl|involved complex|advmod|END_ENTITY	Transferrin , is a mixed chelate-protein ternary complex involved in the mechanism of iron uptake by serum-transferrin in vitro ?
11017929	0	iron	36,40	Transferrin	0,11	iron	Transferrin	MESH:D007501	7018	Chemical	Gene	status|compound|START_ENTITY influences|dobj|status influences|nsubj|polymorphism polymorphism|compound|END_ENTITY	Transferrin polymorphism influences iron status in blacks .
11856741	0	iron	139,143	Transferrin	0,11	iron	Transferrin	MESH:D007501	280705(Tax:9913)	Chemical	Gene	role|nmod|START_ENTITY signaling|nsubj|role responsible|parataxis|signaling responsible|nsubj|uptake uptake|nummod|END_ENTITY	Transferrin receptor-dependent iron uptake is responsible for doxorubicin-mediated apoptosis in endothelial cells : role of oxidant-induced iron signaling in apoptosis .
11856741	0	iron	31,35	Transferrin	0,11	iron	Transferrin	MESH:D007501	280705(Tax:9913)	Chemical	Gene	uptake|compound|START_ENTITY uptake|nummod|END_ENTITY	Transferrin receptor-dependent iron uptake is responsible for doxorubicin-mediated apoptosis in endothelial cells : role of oxidant-induced iron signaling in apoptosis .
12020627	2	iron	338,342	Transferrin	194,205	iron	transferrin	MESH:D007501	7018	Chemical	Gene	release|nmod|START_ENTITY results|nmod|release reabsorption|nmod|results proposed|nmod|reabsorption proposed|nsubjpass|END_ENTITY	Transferrin has also been proposed as a mediator of tubular toxicity because the reabsorption of transferrin results in the release of reactive iron in proximal tubular cells , promoting the formation of hydroxyl radicals .
1312808	0	iron	35,39	Transferrin	0,11	iron	Transferrin	MESH:D007501	7018	Chemical	Gene	source|nmod|START_ENTITY END_ENTITY|dep|source	Transferrin : a potential source of iron for oxygen free radical-mediated endothelial cell injury .
1394993	0	iron	61,65	Transferrin	0,11	iron	Transferrin	MESH:D007501	7018	Chemical	Gene	saturation|compound|START_ENTITY calculating|dobj|saturation method|acl|calculating index|dep|method index|compound|END_ENTITY	Transferrin index : an alternative method for calculating the iron saturation of transferrin .
1419828	0	iron	78,82	Transferrin	0,11	iron	Transferrin	MESH:D007501	24825(Tax:10116)	Chemical	Gene	saturation|compound|START_ENTITY degree|nmod|saturation independent|nmod|degree independent|nsubj|macrophages macrophages|nummod|END_ENTITY	Transferrin uptake by bone marrow macrophages is independent of the degree of iron saturation .
15048869	0	iron	133,137	Transferrin	0,11	iron	Transferrin	MESH:D007501	7018	Chemical	Gene	homeostasis|compound|START_ENTITY regulation|nmod|homeostasis sufficient|nmod|regulation corrected|ccomp|sufficient corrected|nsubj|-LSB- -LSB-|compound|END_ENTITY	Transferrin -LSB- corrected -RSB- receptor association and endosomal localization of soluble HFE are not sufficient for regulation of cellular iron homeostasis .
1919575	0	iron	61,65	Transferrin	0,11	iron	Transferrin	MESH:D007501	24825(Tax:10116)	Chemical	Gene	status|compound|START_ENTITY effects|nmod|status uptake|dep|effects uptake|compound|END_ENTITY	Transferrin and iron uptake by the brain : effects of altered iron status .
21547017	0	iron	27,31	Transferrin	0,11	iron	Transferrin	MESH:D007501	7018	Chemical	Gene	source|nmod|START_ENTITY END_ENTITY|nmod|source	Transferrin as a source of iron for Campylobacter rectus .
24194250	0	iron	38,42	Transferrin	0,11	iron	Transferrin	MESH:D007501	100136560(Tax:8030)	Chemical	Gene	storage|compound|START_ENTITY mRNA|nmod|storage mRNA|compound|END_ENTITY	Transferrin mRNA in relation to liver iron storage in farmed Atlantic_salmonSalmo_salar .
24383984	0	iron	26,30	Transferrin	88,99	iron	Transferrin	MESH:D007501	7018	Chemical	Gene	uptake|compound|START_ENTITY suppresses|dobj|uptake suppresses|nmod|inhibition inhibition|nmod|endocytosis endocytosis|amod|END_ENTITY	Lentiviral Nef suppresses iron uptake in a strain specific manner through inhibition of Transferrin endocytosis .
26743084	0	iron	83,87	Transferrin	53,64	iron	Transferrin	MESH:D007501	7018	Chemical	Gene	extrudes|dobj|START_ENTITY extrudes|nsubj|retroendocytosis retroendocytosis|nmod|END_ENTITY	Reverse overshot water-wheel retroendocytosis of Apo Transferrin extrudes cellular iron .
2989832	0	iron	82,86	Transferrin	0,11	iron	Transferrin	MESH:D007501	24825(Tax:10116)	Chemical	Gene	distribution|compound|START_ENTITY pattern|nmod|distribution receptors|dep|pattern receptors|compound|END_ENTITY	Transferrin receptors in rat brain : neuropeptide-like pattern and relationship to iron distribution .
6095919	0	iron	26,30	Transferrin	0,11	iron	Transferrin	MESH:D007501	24825(Tax:10116)	Chemical	Gene	donor|nmod|START_ENTITY END_ENTITY|nmod|donor	Transferrin as a donor of iron to mitochondria .
6375346	0	iron	84,88	Transferrin	0,11	iron	Transferrin	MESH:D007501	7018	Chemical	Gene	saturation|nmod|START_ENTITY regulation|nmod|saturation defects|nmod|regulation II|dep|defects END_ENTITY|nmod|II	Transferrin in disease II : defects in the regulation of transferrin saturation with iron contribute to susceptibility to infection .
7601141	0	iron	29,33	Transferrin	0,11	iron	Transferrin	MESH:D007501	7018	Chemical	Gene	release|compound|START_ENTITY mechanism|nmod|release END_ENTITY|appos|mechanism	Transferrin , a mechanism for iron release .
7628272	0	iron	57,61	Transferrin	0,11	iron	Transferrin	MESH:D007501	24825(Tax:10116)	Chemical	Gene	process|nmod|START_ENTITY involved|nmod|process involved|nsubjpass|END_ENTITY	Transferrin is not involved in initial uptake process of iron in rat duodenal mucosa .
8427986	0	iron	70,74	Transferrin	0,11	iron	Transferrin	MESH:D007501	22041(Tax:10090)	Chemical	Gene	content|compound|START_ENTITY synthesis|dep|content synthesis|compound|END_ENTITY	Transferrin synthesis by mouse lymph node and peritoneal macrophages : iron content and effect on lymphocyte proliferation .
9616166	0	iron	48,52	Transferrin	0,11	iron	Transferrin	MESH:D007501	7018	Chemical	Gene	transport|compound|START_ENTITY and|dep|transport and|compound|END_ENTITY	Transferrin receptor-dependent and - independent iron transport in gallium-resistant human lymphoid leukemic cells .
9850571	0	iron	105,109	Transferrin	0,11	iron	Transferrin	MESH:D007501	22041(Tax:10090)	Chemical	Gene	accumulation|compound|START_ENTITY effects|nmod|accumulation response|dep|effects response|compound|END_ENTITY	Transferrin response in normal and iron-deficient mice heterozygotic for hypotransferrinemia ; effects on iron and manganese accumulation .
10318901	0	iron	107,111	Transferrin_receptor	0,20	iron	Transferrin receptor	MESH:D007501	7037	Chemical	Gene	homeostasis|compound|START_ENTITY implications|nmod|homeostasis HFE|dep|implications modulated|nmod|HFE modulated|nsubjpass|END_ENTITY	Transferrin_receptor is negatively modulated by the hemochromatosis protein HFE : implications for cellular iron homeostasis .
10730863	0	iron	99,103	Transferrin_receptor	0,20	iron	Transferrin receptor	MESH:D007501	7037	Chemical	Gene	controlled|nmod|START_ENTITY controlled|nsubjpass|expression expression|amod|END_ENTITY	Transferrin_receptor expression is controlled differently by transferrin-bound and non-transferrin iron in human cells .
12856975	0	iron	58,62	Transferrin_receptor	0,20	iron	Transferrin receptor	MESH:D007501	7037	Chemical	Gene	status|compound|START_ENTITY END_ENTITY|nmod|status	Transferrin_receptor in children and its correlation with iron status and types of milk consumption .
20604729	0	iron	64,68	Transferrin_receptor	0,20	iron	Transferrin receptor	MESH:D007501	7037	Chemical	Gene	status|compound|START_ENTITY marker|nmod|status reticulocytes|nmod|marker expression|nmod|reticulocytes expression|amod|END_ENTITY	Transferrin_receptor expression on reticulocytes as a marker of iron status in dialyzed patients .
12531241	0	iron	42,46	Transferrin_receptor_2	0,22	iron	Transferrin receptor 2	MESH:D007501	7036	Chemical	Gene	metabolism|compound|START_ENTITY molecule|nmod|metabolism END_ENTITY|dep|molecule	Transferrin_receptor_2 : a new molecule in iron metabolism .
18083267	0	iron	86,90	Transferrin_receptor_2	0,22	iron	Transferrin receptor 2	MESH:D007501	100752766	Chemical	Gene	uptake|nmod|START_ENTITY mediates|dobj|uptake mediates|nsubj|END_ENTITY	Transferrin_receptor_2 mediates uptake of transferrin-bound and non-transferrin-bound iron .
20576915	0	iron	38,42	Transferrin_receptor_2	0,22	iron	Transferrin receptor 2	MESH:D007501	7036	Chemical	Gene	crucial|nmod|START_ENTITY crucial|nsubj|END_ENTITY	Transferrin_receptor_2 is crucial for iron sensing in human hepatocytes .
22898811	0	iron	11,15	ZIP8	0,4	iron	ZIP8	MESH:D007501	64116	Chemical	Gene	transporter|compound|START_ENTITY transporter|nsubj|END_ENTITY	ZIP8 is an iron and zinc transporter whose cell-surface expression is up-regulated by cellular iron loading .
22898811	0	iron	95,99	ZIP8	0,4	iron	ZIP8	MESH:D007501	64116	Chemical	Gene	loading|compound|START_ENTITY up-regulated|nmod|loading transporter|acl:relcl|up-regulated transporter|nsubj|END_ENTITY	ZIP8 is an iron and zinc transporter whose cell-surface expression is up-regulated by cellular iron loading .
16950869	0	iron	48,52	Zip14	0,5	iron	Zip14	MESH:D007501	23516	Chemical	Gene	uptake|compound|START_ENTITY mediates|dobj|uptake mediates|nsubj|END_ENTITY	Zip14 -LRB- Slc39a14 -RRB- mediates non-transferrin-bound iron uptake into cells .
22581044	0	iron	66,70	a-Synuclein	0,11	iron	a-Synuclein	MESH:D007501	6622	Chemical	Gene	modulated|nmod|START_ENTITY modulated|nsubjpass|expression expression|amod|END_ENTITY	a-Synuclein expression is modulated at the translational level by iron .
12397016	0	iron	21,25	activator_protein-1_and_nuclear_factor_of_activated_T_cells	61,120	iron	activator protein-1 and nuclear factor of activated T cells	MESH:D007501	16476(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Role of bioavailable iron in coal dust-induced activation of activator_protein-1_and_nuclear_factor_of_activated_T_cells : difference between Pennsylvania and Utah coal dusts .
22916096	0	iron	38,42	amyloid_precursor_protein	60,85	iron	amyloid precursor protein	MESH:D007501	351	Chemical	Gene	motif|compound|START_ENTITY motif|nmod|END_ENTITY	A synthetic peptide with the putative iron binding motif of amyloid_precursor_protein -LRB- APP -RRB- does not catalytically oxidize iron .
11796829	0	iron	9,13	angiotensin_II	64,78	iron	angiotensin II	MESH:D007501	24179(Tax:10116)	Chemical	Gene	deposition|compound|START_ENTITY deposition|nmod|rat rat|nmod|administration administration|compound|END_ENTITY	Abnormal iron deposition in renal cells in the rat with chronic angiotensin_II administration .
15627796	2	iron	312,316	angiotensin_II	352,366	iron	angiotensin II	MESH:D007501	24179(Tax:10116)	Chemical	Gene	administration|nmod|START_ENTITY mimics|nsubj|administration mimics|dobj|renal_damage renal_damage|acl|induced induced|nmod|END_ENTITY	We have investigated whether administration of iron mimics the renal_damage induced by angiotensin_II .
20431588	0	iron	101,105	angiotensin_II	10,24	iron	angiotensin II	MESH:D007501	183	Chemical	Gene	concentration|compound|START_ENTITY labile|dobj|concentration labile|nsubj|Effect Effect|nmod|END_ENTITY	Effect of angiotensin_II on iron-transporting protein expression and subsequent intracellular labile iron concentration in human glomerular endothelial cells .
1845997	0	iron	8,12	apoferritin	39,50	iron	apoferritin	MESH:D007501	100062811(Tax:9796)	Chemical	Gene	oxidation|compound|START_ENTITY oxidation|nmod|END_ENTITY	Initial iron oxidation in horse spleen apoferritin .
2007131	0	iron	29,33	apoferritin	48,59	iron	apoferritin	MESH:D007501	2495	Chemical	Gene	deposition|compound|START_ENTITY deposition|nmod|END_ENTITY	Role of phosphate in initial iron deposition in apoferritin .
2065674	0	iron	10,14	apoferritin	18,29	iron	apoferritin	MESH:D007501	100062811(Tax:9796)	Chemical	Gene	Uptake|nmod|START_ENTITY Uptake|nmod|END_ENTITY	Uptake of iron by apoferritin from a ferric_dihydrolipoate complex .
2539862	0	iron	22,26	apoferritin	45,56	iron	apoferritin	MESH:D007501	2495	Chemical	Gene	channels|compound|START_ENTITY Identification|nmod|channels Identification|nmod|END_ENTITY	Identification of the iron entry channels in apoferritin .
7951057	0	iron	47,51	apoferritin	63,74	iron	apoferritin	MESH:D007501	2495	Chemical	Gene	loading|compound|START_ENTITY loading|nmod|END_ENTITY	Xanthine oxidase : an efficient promoter of the iron loading of apoferritin .
7999768	0	iron	63,67	apoferritin	91,102	iron	apoferritin	MESH:D007501	100062811(Tax:9796)	Chemical	Gene	uptake|compound|START_ENTITY formed|nmod|uptake formed|nmod|END_ENTITY	Rapid kinetics of the EPR-active species formed during initial iron uptake in horse spleen apoferritin .
8343534	0	iron	18,22	apoferritin	78,89	iron	apoferritin	MESH:D007501	100062811(Tax:9796)	Chemical	Gene	core|compound|START_ENTITY Nucleation|nmod|core occurs|nsubj|Nucleation occurs|nmod|channels channels|nmod|END_ENTITY	Nucleation of the iron core occurs at the three-fold channels of horse spleen apoferritin : an EXAFS study on the native and chemically-modified protein .
871433	0	iron	38,42	apoferritin	82,93	iron	apoferritin	MESH:D007501	2495	Chemical	Gene	overload|compound|START_ENTITY ferritin|nmod|overload Characterization|nmod|ferritin Characterization|dep|identity identity|nmod|END_ENTITY	Characterization of serum ferritin in iron overload : possible identity to natural apoferritin .
1854807	0	iron	21,25	arachidonate_12-lipoxygenase	29,57	iron	arachidonate 12-lipoxygenase	MESH:D007501	239	Chemical	Gene	Analysis|nmod|START_ENTITY Analysis|nmod|END_ENTITY	Analysis of non-heme iron in arachidonate_12-lipoxygenase of porcine leukocytes .
22009536	0	iron	29,33	b-catenin	48,57	iron	b-catenin	MESH:D007501	1499	Chemical	Gene	dependence|compound|START_ENTITY dependence|nmod|END_ENTITY	Wnt inhibitor screen reveals iron dependence of b-catenin signaling in cancers .
10485908	0	iron	81,85	ceruloplasmin	55,68	iron	ceruloplasmin	MESH:D007501	12870(Tax:10090)	Chemical	Gene	efflux|compound|START_ENTITY END_ENTITY|nmod|efflux	Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux .
16271531	0	iron	47,51	ceruloplasmin	19,32	iron	ceruloplasmin	MESH:D007501	12870(Tax:10090)	Chemical	Gene	absorption|compound|START_ENTITY role|nmod|absorption role|nmod|END_ENTITY	Unexpected role of ceruloplasmin in intestinal iron absorption .
19173569	0	iron	24,28	cytochrome_C	32,44	iron	cytochrome C	MESH:D007501	54205	Chemical	Gene	dynamics|nmod|START_ENTITY dynamics|nmod|END_ENTITY	Vibrational dynamics of iron in cytochrome_C .
8821818	0	iron	55,59	cytochrome_P-450	13,29	iron	cytochrome P-450	MESH:D007501	25251(Tax:10116)	Chemical	Gene	source|nmod|START_ENTITY END_ENTITY|nmod|source	Evidence for cytochrome_P-450 as a source of catalytic iron in myoglobinuric acute_renal_failure .
9844132	0	iron	50,54	cytochrome_P-450	8,24	iron	cytochrome P-450	MESH:D007501	25251(Tax:10116)	Chemical	Gene	source|nmod|START_ENTITY END_ENTITY|nmod|source	Role of cytochrome_P-450 as a source of catalytic iron in cisplatin-induced nephrotoxicity .
15211619	0	iron	13,17	cytochrome_P4501A1	62,80	iron	cytochrome P4501A1	MESH:D007501	24296(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|upregulation upregulation|nmod|END_ENTITY	Influence of iron -LRB- 56Fe2O3 or 54Fe2O3 -RRB- in the upregulation of cytochrome_P4501A1 by benzo -LSB- a -RSB- pyrene in the respiratory tract of Sprague-Dawley_rats .
11313311	0	iron	27,31	divalent-metal_transporter_1	45,73	iron	divalent-metal transporter 1	MESH:D007501	4891	Chemical	Gene	Expression|nmod|START_ENTITY transporters|nsubj|Expression transporters|xcomp|END_ENTITY	Expression of the duodenal iron transporters divalent-metal_transporter_1 and ferroportin_1 in iron_deficiency and iron_overload .
12547225	0	iron	67,71	duodenal_cytochrome_B	34,55	iron	duodenal cytochrome B	MESH:D007501	79901	Chemical	Gene	metabolism|compound|START_ENTITY roles|nmod|metabolism roles|nmod|END_ENTITY	Molecular and functional roles of duodenal_cytochrome_B -LRB- Dcytb -RRB- in iron metabolism .
17087784	0	iron	88,92	duodenal_cytochrome_B	22,43	iron	duodenal cytochrome B	MESH:D007501	79901	Chemical	Gene	status|compound|START_ENTITY markers|nmod|status circulating|dobj|markers relationship|acl|circulating Immunolocalization|dep|relationship Immunolocalization|nmod|END_ENTITY	Immunolocalization of duodenal_cytochrome_B : a relationship with circulating markers of iron status .
15961514	0	iron	60,64	duodenal_cytochrome_b	8,29	iron	duodenal cytochrome b	MESH:D007501	73649(Tax:10090)	Chemical	Gene	absorption|compound|START_ENTITY necessary|nmod|absorption necessary|nsubj|Cybrd1 Cybrd1|appos|END_ENTITY	Cybrd1 -LRB- duodenal_cytochrome_b -RRB- is not necessary for dietary iron absorption in mice .
18194661	0	iron	101,105	duodenal_cytochrome_b	37,58	iron	duodenal cytochrome b	MESH:D007501	79901	Chemical	Gene	properties|acl|START_ENTITY characterization|dep|properties characterization|nmod|END_ENTITY	Functional characterization of human duodenal_cytochrome_b -LRB- Cybrd1 -RRB- : Redox properties in relation to iron and ascorbate metabolism .
15626777	0	iron	8,12	epidermal_growth_factor_receptor	32,64	iron	epidermal growth factor receptor	MESH:D007501	1956	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of iron in inactivation of epidermal_growth_factor_receptor after asbestos treatment of human lung and pleural target cells .
19814679	0	iron	13,17	era	6,9	iron	era	MESH:D007501	26284	Chemical	Gene	therapy|compound|START_ENTITY END_ENTITY|nmod|therapy	A new era in iron chelation therapy : the design of optimal , individually adjusted iron chelation therapies for the complete removal of iron overload in thalassemia and other chronically transfused patients .
19814679	0	iron	135,139	era	6,9	iron	era	MESH:D007501	26284	Chemical	Gene	overload|compound|START_ENTITY removal|nmod|overload adjusted|nmod|removal adjusted|nsubj|END_ENTITY	A new era in iron chelation therapy : the design of optimal , individually adjusted iron chelation therapies for the complete removal of iron overload in thalassemia and other chronically transfused patients .
19814679	0	iron	82,86	era	6,9	iron	era	MESH:D007501	26284	Chemical	Gene	therapies|compound|START_ENTITY adjusted|dobj|therapies adjusted|nsubj|END_ENTITY	A new era in iron chelation therapy : the design of optimal , individually adjusted iron chelation therapies for the complete removal of iron overload in thalassemia and other chronically transfused patients .
10048613	0	iron	5,9	erythropoietin	28,42	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	sufficient|nsubj|START_ENTITY sufficient|nmod|treatment treatment|compound|END_ENTITY	Oral iron is sufficient for erythropoietin treatment of very low birth-weight infants .
10050100	0	iron	93,97	erythropoietin	22,36	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	supplementation|compound|START_ENTITY coaster|nmod|supplementation changing|nmod|coaster save|advcl|changing save|dobj|money money|nmod|therapy therapy|compound|END_ENTITY	How to save money for erythropoietin therapy by changing from ` roller coaster ' to continuous iron supplementation .
10233880	0	iron	107,111	erythropoietin	32,46	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	supply|compound|START_ENTITY adequacy|nmod|supply modulated|nmod|adequacy modulated|nsubjpass|effect effect|nmod|END_ENTITY	The effect of recombinant human erythropoietin on platelet counts is strongly modulated by the adequacy of iron supply .
10234700	0	iron	8,12	erythropoietin	66,80	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	START_ENTITY|acl|optimizing optimizing|nmod|END_ENTITY	Role of iron in optimizing responses of anemic cancer patients to erythropoietin .
10355137	0	iron	48,52	erythropoietin	16,30	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	therapy|compound|START_ENTITY induced|nmod|therapy induced|nsubj|level level|compound|END_ENTITY	-LSB- Decrease serum erythropoietin level induced by iron replacement therapy in patients with iron_deficiency_anemia -RSB- .
10651841	0	iron	65,69	erythropoietin	29,43	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	therapy|compound|START_ENTITY sucrose|nmod|therapy sucrose|nsubj|Effectiveness Effectiveness|nmod|END_ENTITY	Effectiveness of recombinant erythropoietin and iron sucrose vs. iron therapy only , in patients with postpartum anaemia and blunted erythropoiesis .
10657727	0	iron	70,74	erythropoietin	21,35	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	supplementation|compound|START_ENTITY response|nmod|supplementation response|nmod|therapy therapy|compound|END_ENTITY	Improved response to erythropoietin therapy with long-term continuous iron supplementation .
10682073	0	iron	29,33	erythropoietin	165,179	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	dextran|compound|START_ENTITY intraperitoneal|dobj|dextran intraperitoneal|nmod|patients patients|acl|receiving receiving|dobj|END_ENTITY	Use of bolus intraperitoneal iron dextran in continuous ambulatory peritoneal dialysis or continuous cyclic peritoneal dialysis patients receiving recombinant human erythropoietin .
10850644	0	iron	37,41	erythropoietin	11,25	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	absorption|compound|START_ENTITY Effects|nmod|absorption Effects|nmod|therapy therapy|compound|END_ENTITY	Effects of erythropoietin therapy on iron absorption in chronic_renal_failure .
10907637	0	iron	54,58	erythropoietin	25,39	iron	erythropoietin	MESH:D007501	13856(Tax:10090)	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|expression expression|compound|END_ENTITY	Modulation of transduced erythropoietin expression by iron .
10982248	0	iron	24,28	erythropoietin	122,136	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	supplementation|compound|START_ENTITY Intravenous|nmod|supplementation synthesis|nsubj|Intravenous synthesis|xcomp|using using|dobj|END_ENTITY	Intravenous versus oral iron supplementation for preoperative stimulation of hemoglobin synthesis using recombinant human erythropoietin .
11126152	0	iron	38,42	erythropoietin	94,108	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	supplementation|compound|START_ENTITY characteristic|nmod|supplementation characteristic|acl|receiving receiving|dobj|therapy therapy|compound|END_ENTITY	Clinical characteristic of parenteral iron supplementation in hemodialysis patients receiving erythropoietin therapy .
11227366	1	iron	44,48	erythropoietin	71,85	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|treatment treatment|nmod|-RSB- -RSB-|compound|END_ENTITY	Role of iron in the treatment with erythropoietin -RSB- .
11262469	0	iron	50,54	erythropoietin	107,121	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	Efficacy|nmod|START_ENTITY sucrose|nsubj|Efficacy sucrose|nmod|END_ENTITY	Efficacy and safety of intravenously administered iron sucrose with and without adjuvant recombinant human erythropoietin for the treatment of resistant iron-deficiency_anemia during pregnancy .
11316241	0	iron	19,23	erythropoietin	62,76	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of i.v. iron alone or in combination with low-dose erythropoietin in the rapid correction of anemia of chronic_renal_failure in the predialysis period .
11328902	0	iron	42,46	erythropoietin	125,139	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	supplementation|compound|START_ENTITY study|nmod|supplementation study|acl|treated treated|nmod|END_ENTITY	A randomized study of oral vs intravenous iron supplementation in patients with progressive renal_insufficiency treated with erythropoietin .
11427634	0	iron	12,16	erythropoietin	116,130	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	status|compound|START_ENTITY role|nmod|status markers|nsubj|role markers|advcl|predicting predicting|nmod|iron iron|nmod|patients patients|nmod|END_ENTITY	The role of iron status markers in predicting response to intravenous iron in haemodialysis patients on maintenance erythropoietin .
11427634	0	iron	70,74	erythropoietin	116,130	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	The role of iron status markers in predicting response to intravenous iron in haemodialysis patients on maintenance erythropoietin .
11524849	0	iron	28,32	erythropoietin	80,94	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	depletion|compound|START_ENTITY using|dobj|depletion treatment|acl|using combined|nsubj|treatment combined|nmod|END_ENTITY	-LSB- Successful treatment using iron depletion phlebotomy combined with recombinant erythropoietin after allogeneic bone marrow transplantation for myelodysplastic_syndrome complicated by secondary hemochromatosis -RSB- .
11528242	0	iron	31,35	erythropoietin	55,69	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	Effect|nmod|START_ENTITY supplementation|nsubj|Effect supplementation|nmod|doses doses|compound|END_ENTITY	Effect of weekly or successive iron supplementation on erythropoietin doses in patients receiving hemodialysis .
11533837	0	iron	27,31	erythropoietin	55,69	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	role|nmod|START_ENTITY supplementation|nsubj|role supplementation|nmod|therapy therapy|compound|END_ENTITY	The role of high-dose oral iron supplementation during erythropoietin therapy for anemia of prematurity .
11682666	0	iron	66,70	erythropoietin	35,49	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	requirements|compound|START_ENTITY requirements|compound|END_ENTITY	Role of type of vascular access in erythropoietin and intravenous iron requirements in haemodialysis .
11770580	0	iron	12,16	erythropoietin	63,77	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	therapy|compound|START_ENTITY therapy|nmod|levels levels|compound|END_ENTITY	Intravenous iron therapy for severe pregnancy anemia with high erythropoietin levels .
11863124	0	iron	68,72	erythropoietin	13,27	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	use|nmod|START_ENTITY doses|nmod|use doses|compound|END_ENTITY	Reduction in erythropoietin doses by the use of chronic intravenous iron supplementation in iron-replete hemodialysis patients .
11975695	0	iron	43,47	erythropoietin	61,75	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	doses|compound|START_ENTITY individualizing|dobj|doses individualizing|nmod|therapy therapy|compound|END_ENTITY	Nomogram for individualizing supplementary iron doses during erythropoietin therapy in haemodialysis patients .
12038884	0	iron	16,20	erythropoietin	66,80	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	doses|compound|START_ENTITY Comparison|nmod|doses Comparison|acl|receiving receiving|dobj|therapy therapy|compound|END_ENTITY	Comparison of 2 iron doses in infants receiving recombinant human erythropoietin therapy .
12071600	0	iron	21,25	erythropoietin	105,119	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	administration|compound|START_ENTITY treated|nsubj|administration treated|nmod|END_ENTITY	Low-dose intravenous iron administration in chronic hemodialysis patients treated with recombinant human erythropoietin .
12091601	0	iron	12,16	erythropoietin	66,80	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	role|nmod|START_ENTITY role|nmod|erythropoiesis erythropoiesis|nmod|absence absence|nmod|therapy therapy|compound|END_ENTITY	The role of iron in erythropoiesis in the absence and presence of erythropoietin therapy .
12360794	0	iron	61,65	erythropoietin	74,88	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	effect|nmod|START_ENTITY hemodialysis|appos|effect Correction|nmod|hemodialysis Correction|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Correction of anemia in hemodialysis , effect of intravenous iron without erythropoietin -RSB- .
12725261	0	iron	38,42	erythropoietin	128,142	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	therapy|compound|START_ENTITY oral|nmod|therapy Comparison|nmod|oral Comparison|acl|receiving receiving|dobj|END_ENTITY	Comparison of oral versus intravenous iron therapy in predialysis patients of chronic_renal_failure receiving recombinant human erythropoietin .
12846752	0	iron	10,14	erythropoietin	101,115	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	treatment|compound|START_ENTITY treatment|acl|circulating circulating|nmod|patients patients|acl|receiving receiving|dobj|END_ENTITY	Effect of iron treatment on circulating cytokine levels in ESRD patients receiving recombinant human erythropoietin .
1295714	0	iron	46,50	erythropoietin	28,42	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	balance|compound|START_ENTITY END_ENTITY|nmod|balance	Effect of recombinant human erythropoietin on iron balance in maintenance hemodialysis : theoretical considerations , clinical experience and consequences .
1419827	0	iron	14,18	erythropoietin	128,142	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	absorption|compound|START_ENTITY Regulation|nmod|absorption loaded|nsubj|Regulation loaded|dobj|subjects subjects|dep|effects effects|nmod|treatment treatment|nmod|END_ENTITY	Regulation of iron absorption in iron loaded subjects with end_stage_renal_disease : effects of treatment with recombinant human erythropoietin and reduction of iron stores .
1419827	0	iron	33,37	erythropoietin	128,142	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	absorption|nmod|START_ENTITY Regulation|nmod|absorption loaded|nsubj|Regulation loaded|dobj|subjects subjects|dep|effects effects|nmod|treatment treatment|nmod|END_ENTITY	Regulation of iron absorption in iron loaded subjects with end_stage_renal_disease : effects of treatment with recombinant human erythropoietin and reduction of iron stores .
1442178	0	iron	15,19	erythropoietin	83,97	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	requirements|compound|START_ENTITY Assessment|nmod|requirements Assessment|nmod|END_ENTITY	-LSB- Assessment of iron requirements during treatment of anemia with recombinant human erythropoietin in patients with chronic_renal_insufficiency under hemodialysis -RSB- .
14640239	0	iron	58,62	erythropoietin	78,92	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	dextran|compound|START_ENTITY Targeting|nmod|dextran lowers|csubj|Targeting lowers|dobj|requirement requirement|compound|END_ENTITY	Targeting higher ferritin concentrations with intravenous iron dextran lowers erythropoietin requirement in hemodialysis patients .
1501748	0	iron	55,59	erythropoietin	99,113	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	effects|nmod|START_ENTITY potentiating|dobj|effects underlying|advcl|potentiating mechanisms|acl|underlying chelators|nsubj|mechanisms chelators|nmod|END_ENTITY	Possible mechanisms underlying potentiating effects of iron chelators in hematopoietic response to erythropoietin .
15051778	0	iron	12,16	erythropoietin	61,75	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	optimizes|nsubj|START_ENTITY optimizes|nmod|END_ENTITY	Intravenous iron optimizes the response to recombinant human erythropoietin in cancer patients with chemotherapy-related anemia : a multicenter , open-label , randomized trial .
1519605	0	iron	14,18	erythropoietin	103,117	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	status|compound|START_ENTITY Assessment|nmod|status ferritin|nsubj|Assessment ferritin|nmod|therapy therapy|compound|END_ENTITY	Assessment of iron status by erythrocyte ferritin in uremic patients with or without recombinant human erythropoietin therapy .
15660859	0	iron	5,9	erythropoietin	58,72	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	supplementation|compound|START_ENTITY treated|nsubj|supplementation treated|nmod|END_ENTITY	Oral iron supplementation in preterm infants treated with erythropoietin .
16431410	0	iron	90,94	erythropoietin	118,132	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	infusions|nmod|START_ENTITY events|nmod|infusions incidence|nmod|events sucrose|nsubj|incidence sucrose|nmod|children children|nmod|END_ENTITY	Low incidence of adverse events following 90-minute and 3-minute infusions of intravenous iron sucrose in children on erythropoietin .
1649718	0	iron	47,51	erythropoietin	136,150	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	status|compound|START_ENTITY monitoring|dobj|status monitoring|nmod|haemosiderosis haemosiderosis|acl|treated treated|nmod|END_ENTITY	Hepatic computed tomography for monitoring the iron status of haemodialysis patients with haemosiderosis treated with recombinant human erythropoietin .
16960172	0	iron	157,161	erythropoietin	84,98	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	changing|dobj|START_ENTITY increases|advcl|changing increases|dobj|concentrations concentrations|compound|END_ENTITY	Vitamin_A supplementation in children with poor vitamin_A and iron status increases erythropoietin and hemoglobin concentrations without changing total body iron .
16965592	0	iron	10,14	erythropoietin	90,104	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	absorption|compound|START_ENTITY supported|nsubj|absorption supported|nmod|therapy therapy|compound|END_ENTITY	Increased iron absorption during autologous blood donation supported by recombinant human erythropoietin therapy .
17106764	0	iron	88,92	erythropoietin	116,130	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	independent|compound|START_ENTITY independent|nmod|END_ENTITY	Iron_deficiency in patients with chronic_kidney_disease : potential role for intravenous iron therapy independent of erythropoietin .
17353176	0	iron	60,64	erythropoietin	112,126	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	availability|compound|START_ENTITY availability|nmod|chronic_kidney_diseases chronic_kidney_diseases|nmod|therapy therapy|compound|END_ENTITY	Reticulocyte hemoglobin equivalent : an indicator of reduced iron availability in chronic_kidney_diseases during erythropoietin therapy .
1742921	0	iron	50,54	erythropoietin	32,46	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	absorption|compound|START_ENTITY effect|nmod|absorption effect|nmod|END_ENTITY	The effect of human recombinant erythropoietin on iron absorption and hepatic iron in a rat model .
17704954	0	iron	12,16	erythropoietin	80,94	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	treatment|compound|START_ENTITY treatment|nmod|END_ENTITY	Intravenous iron treatment in paediatric chronic_kidney_disease patients not on erythropoietin .
1782724	0	iron	5,9	erythropoietin	59,73	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	absorption|compound|START_ENTITY treated|nsubj|absorption treated|nmod|END_ENTITY	Oral iron absorption in hemodialysis patients treated with erythropoietin .
1788107	0	iron	14,18	erythropoietin	76,90	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|nmod|efficacy efficacy|nmod|treatment treatment|appos|END_ENTITY	-LSB- Influence of iron metabolism on the efficacy of r-HuEPO -LRB- recombinant human erythropoietin -RRB- treatment of anemia in children on hemodialysis -RSB- .
18189270	0	iron	83,87	erythropoietin	116,130	iron	erythropoietin	MESH:D007501	24335(Tax:10116)	Chemical	Gene	retention|compound|START_ENTITY retention|nmod|macrophages macrophages|nmod|END_ENTITY	Decreased DMT1 and increased ferroportin_1 expression is the mechanisms of reduced iron retention in macrophages by erythropoietin in rats .
18209438	0	iron	31,35	erythropoietin	90,104	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	supplementation|compound|START_ENTITY physicians|nmod|supplementation Attitude|nmod|physicians treated|nsubj|Attitude treated|nmod|END_ENTITY	Attitude of physicians towards iron supplementation in hemodialysis patients treated with erythropoietin .
18410348	0	iron	12,16	erythropoietin	128,142	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|nmod|vaccination vaccination|nmod|patients patients|nmod|therapy therapy|compound|END_ENTITY	Intravenous iron attenuates postvaccination anti-HBsAg titres after quadruple hepatitis_B vaccination in dialysis patients with erythropoietin therapy .
18414140	0	iron	58,62	erythropoietin	88,102	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	availability|nmod|START_ENTITY indicating|dobj|availability indices|acl|indicating associated|nsubjpass|indices associated|nmod|concentration concentration|compound|END_ENTITY	Novel red cell indices indicating reduced availability of iron are associated with high erythropoietin concentration and low ph level in the venous cord blood of newborns .
18446719	0	iron	61,65	erythropoietin	25,39	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	deficiency_anemia|compound|START_ENTITY treatment|nmod|deficiency_anemia END_ENTITY|nmod|treatment	Intravenous iron without erythropoietin for the treatment of iron deficiency_anemia in patients with moderate to severe congestive_heart_failure and chronic_kidney_insufficiency .
1920844	0	iron	14,18	erythropoietin	66,80	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	overload|compound|START_ENTITY Treatment|nmod|overload Treatment|nmod|END_ENTITY	-LSB- Treatment of iron overload with combination of recombinant human erythropoietin and phlebotomy -RSB- .
19264680	0	iron	35,39	erythropoietin	103,117	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	metabolism|compound|START_ENTITY Alterations|nmod|metabolism treated|nsubj|Alterations treated|nmod|END_ENTITY	Alterations of systemic and muscle iron metabolism in human subjects treated with low-dose recombinant erythropoietin .
20624257	0	iron	23,27	erythropoietin	69,83	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	Effects|nmod|START_ENTITY combined|nsubj|Effects combined|nmod|END_ENTITY	Effects of intravenous iron combined with low-dose recombinant human erythropoietin on transfusion requirements in iron-deficient patients undergoing bilateral total knee replacement arthroplasty .
20694291	0	iron	47,51	erythropoietin	140,154	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	metabolism|compound|START_ENTITY indicators|nmod|metabolism relation|nmod|indicators Pro-hepcidin|appos|relation hemodialyzed|nsubj|Pro-hepcidin hemodialyzed|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Pro-hepcidin , its relation with indicators of iron metabolism and of inflammation in patients hemodialyzed treated or not with recombinant erythropoietin -RSB- .
2077417	0	iron	22,26	erythropoietin	91,105	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	overload|compound|START_ENTITY overload|nmod|patient patient|nmod|END_ENTITY	Correction of serious iron overload in a chronic hemodialysis patient by recombinant human erythropoietin and removal of red blood cells : confirmation by follow-up liver biopsy .
2239935	0	iron	19,23	erythropoietin	62,76	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	START_ENTITY|nmod|patients patients|acl|treated treated|nmod|END_ENTITY	Bioavailability of iron in hemodialysis patients treated with erythropoietin : evidence for the inhibitory role of aluminum .
22652723	0	iron	40,44	erythropoietin	15,29	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	strategies|compound|START_ENTITY response|dep|strategies response|compound|END_ENTITY	Maximizing the erythropoietin response : iron strategies .
22771376	0	iron	56,60	erythropoietin	36,50	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of preoperative intravenous erythropoietin plus iron on outcome in anemic patients after cardiac valve replacement .
22922860	0	iron	15,19	erythropoietin	122,136	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	Efficacy|nmod|START_ENTITY Efficacy|nmod|therapy therapy|compound|END_ENTITY	Efficacy of IV iron compared to oral iron for increment of haemoglobin level in anemic chronic_kidney_disease patients on erythropoietin therapy .
22922860	0	iron	37,41	erythropoietin	122,136	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	iron|acl|START_ENTITY Efficacy|nmod|iron Efficacy|nmod|therapy therapy|compound|END_ENTITY	Efficacy of IV iron compared to oral iron for increment of haemoglobin level in anemic chronic_kidney_disease patients on erythropoietin therapy .
23246125	0	iron	87,91	erythropoietin	58,72	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	replete|compound|START_ENTITY resistance|nmod|replete resistance|compound|END_ENTITY	The relationship between red cell distribution width with erythropoietin resistance in iron replete hemodialysis patients .
23281632	0	iron	108,112	erythropoietin	38,52	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	potency|nmod|START_ENTITY potency|nmod|END_ENTITY	Greater potency of darbepoetin-a than erythropoietin in suppression of serum hepcidin-25 and utilization of iron for erythropoiesis in hemodialysis patients .
2362636	0	iron	60,64	erythropoietin	139,153	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	overload|compound|START_ENTITY patient|nmod|overload Treatment|nmod|patient combined|nsubj|Treatment combined|nmod|END_ENTITY	Treatment of a patient with end-stage_renal_disease , severe iron overload and ascites by weekly phlebotomy combined with recombinant human erythropoietin .
23860963	0	iron	111,115	erythropoietin	141,155	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	status|compound|START_ENTITY markers|nmod|status markers|nmod|END_ENTITY	Ferroportin in monocytes of hemodialysis patients and its associations with hepcidin , inflammation , markers of iron status and resistance to erythropoietin .
25091785	0	iron	11,15	erythropoietin	39,53	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	dose|compound|START_ENTITY Cumulative|dobj|dose Cumulative|nmod|END_ENTITY	Cumulative iron dose and resistance to erythropoietin .
25698609	0	iron	83,87	erythropoietin	104,118	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	using|dobj|START_ENTITY using|nmod|END_ENTITY	Optimizing preoperative haemoglobin in major orthopaedic surgery using intravenous iron with or without erythropoietin .
446656	0	iron	64,68	erythropoietin	42,56	iron	erythropoietin	MESH:D007501	24335(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY alters|dobj|transport alters|nsubj|END_ENTITY	Direct evidence favouring the notion that erythropoietin alters iron transport across the isolated intestinal tract of the rat .
7611266	0	iron	86,90	erythropoietin	31,45	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	supplementation|compound|START_ENTITY use|nmod|supplementation Reduction|nmod|use Reduction|nmod|doses doses|compound|END_ENTITY	Reduction in recombinant human erythropoietin doses by the use of chronic intravenous iron supplementation .
7665066	0	iron	34,38	erythropoietin	60,74	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	renders|compound|START_ENTITY renders|dep|-RSB- -RSB-|compound|END_ENTITY	-LSB- Anemia in puerperium ; parenteral iron substitution renders erythropoietin therapy dispensable -RSB- .
7808929	0	iron	67,71	erythropoietin	29,43	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	parameters|compound|START_ENTITY Effect|nmod|parameters Effect|nmod|END_ENTITY	-LSB- Effect of human recombinant erythropoietin -LRB- r-EPO -RRB- on behavior of iron status parameters in patients with chronic_renal_failure treated with dialysis -RSB- .
7872321	0	iron	17,21	erythropoietin	70,84	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	therapy|compound|START_ENTITY Efficacy|nmod|therapy Efficacy|acl|receiving receiving|dobj|END_ENTITY	Efficacy of oral iron therapy in patients receiving recombinant human erythropoietin .
7881986	0	iron	14,18	erythropoietin	76,90	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	status|compound|START_ENTITY Monitoring|nmod|status treated|nsubj|Monitoring treated|nmod|END_ENTITY	Monitoring of iron status and iron supplementation in patients treated with erythropoietin .
8080013	0	iron	18,22	erythropoietin	43,57	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	stores|compound|START_ENTITY Influence|nmod|stores Influence|nmod|concentration concentration|compound|END_ENTITY	Influence of body iron stores on the serum erythropoietin concentration in hemodialyzed patients .
8105918	0	iron	48,52	erythropoietin	23,37	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Comparative effects of erythropoietin with oral iron in peritoneal dialysis and hemodialysis patients .
8109598	0	iron	130,134	erythropoietin	60,74	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	availability|compound|START_ENTITY importance|nmod|availability Efficacy|dep|importance Efficacy|nmod|regimens regimens|nmod|END_ENTITY	Efficacy of different dosing regimens for recombinant human erythropoietin in a simulated perisurgical setting : the importance of iron availability in optimizing response .
8142226	0	iron	10,14	erythropoietin	64,78	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	status|compound|START_ENTITY status|nmod|children children|nmod|chronic_renal_failure chronic_renal_failure|nmod|END_ENTITY	Assessing iron status in children with chronic_renal_failure on erythropoietin : which measurements should we use ?
8192528	0	iron	14,18	erythropoietin	44,58	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	status|compound|START_ENTITY Importance|nmod|status Importance|acl|monitoring monitoring|nmod|treatment treatment|compound|END_ENTITY	Importance of iron status monitoring during erythropoietin treatment in uremic predialysis patients .
8215878	0	iron	37,41	erythropoietin	7,21	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	dextran|compound|START_ENTITY dextran|compound|END_ENTITY	Use of erythropoietin and parenteral iron dextran in a severely anemic Jehovah 's _ Witness with colon_cancer .
8255518	0	iron	14,18	erythropoietin	53,67	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	requirements|compound|START_ENTITY Monitoring|nmod|requirements Monitoring|nmod|END_ENTITY	Monitoring of iron requirements in renal patients on erythropoietin .
8267408	0	iron	22,26	erythropoietin	76,90	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	management|compound|START_ENTITY management|nmod|therapy therapy|nmod|END_ENTITY	Current perspectives : iron management during therapy with recombinant human erythropoietin .
8350509	0	iron	146,150	erythropoietin	10,24	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	serum|dobj|START_ENTITY linked|advcl|serum linked|nsubj|Assay Assay|nmod|END_ENTITY	-LSB- Assay of erythropoietin in serum with short term enzyme linked immunosorbent assay method -- the clinical significance : Part 2 -- : Relation to serum iron , UIBC and ferritin in renal_failure and hematological_disorders -RSB- .
8377118	1	iron	46,50	erythropoietin	78,92	iron	erythropoietin	MESH:D007501	443302(Tax:9940)	Chemical	Gene	mobilization|compound|START_ENTITY mobilization|nmod|END_ENTITY	Plasma iron mobilization by endogenous erythropoietin in the sheep fetus ; evidence of threshold response in spontaneous hypoxemia .
8639855	0	iron	10,14	erythropoietin	65,79	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	supply|compound|START_ENTITY END_ENTITY|nsubj|supply	Defective iron supply for erythropoiesis and adequate endogenous erythropoietin production in the anemia associated with systemic-onset juvenile_chronic_arthritis .
8643170	0	iron	14,18	erythropoietin	30,44	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	Importance|nmod|START_ENTITY supply|nsubj|Importance supply|nmod|therapy therapy|compound|END_ENTITY	Importance of iron supply for erythropoietin therapy .
8671972	0	iron	29,33	erythropoietin	63,77	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	therapy|compound|START_ENTITY improves|nsubj|therapy improves|nmod|END_ENTITY	Regular low-dose intravenous iron therapy improves response to erythropoietin in haemodialysis patients .
8740313	0	iron	35,39	erythropoietin	64,78	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	supplementation|compound|START_ENTITY supplementation|nmod|therapy therapy|compound|END_ENTITY	Decreased ferritin levels , despite iron supplementation , during erythropoietin therapy in anaemia of prematurity .
8765624	0	iron	37,41	erythropoietin	99,113	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	comparison|nmod|START_ENTITY supplementation|nsubj|comparison supplementation|nmod|infants infants|acl|receiving receiving|dobj|END_ENTITY	A comparison of oral and intravenous iron supplementation in preterm infants receiving recombinant erythropoietin .
8767691	0	iron	10,14	erythropoietin	18,32	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|production production|compound|END_ENTITY	Effect of iron on erythropoietin production in anaemic piglets .
8790155	0	iron	11,15	erythropoietin	32,46	iron	erythropoietin	MESH:D007501	13856(Tax:10090)	Chemical	Gene	increases|compound|START_ENTITY serum|nsubj|increases serum|dobj|concentration concentration|compound|END_ENTITY	Parenteral iron increases serum erythropoietin concentration during the `` early anaemia ' of 10-20-day-old mice .
8865893	0	iron	30,34	erythropoietin	113,127	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	treatment|compound|START_ENTITY treatment|nmod|patients patients|acl|receiving receiving|dobj|END_ENTITY	Efficacy of bolus intravenous iron dextran treatment in peritoneal_dialysis patients receiving recombinant human erythropoietin .
8904521	0	iron	71,75	erythropoietin	25,39	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	Use|nmod|START_ENTITY Use|nmod|END_ENTITY	Use of recombinant human erythropoietin in combination with parenteral iron in the treatment of postpartum anaemia .
8914038	0	iron	33,37	erythropoietin	79,93	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	supplementation|compound|START_ENTITY study|nmod|supplementation controlled|dobj|study controlled|nmod|patients patients|acl|treated treated|nmod|END_ENTITY	A randomized controlled study of iron supplementation in patients treated with erythropoietin .
8969812	0	iron	58,62	erythropoietin	18,32	iron	erythropoietin	MESH:D007501	443302(Tax:9940)	Chemical	Gene	administration|nmod|START_ENTITY administration|compound|END_ENTITY	Effect of chronic erythropoietin administration on plasma iron in newborn lambs .
9002972	0	iron	23,27	erythropoietin	42,56	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|nmod|END_ENTITY	Regulation of cellular iron metabolism by erythropoietin : activation of iron-regulatory protein and upregulation of transferrin_receptor expression in erythroid cells .
9096447	0	iron	37,41	erythropoietin	76,90	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	estimating|dobj|START_ENTITY approach|acl|estimating needs|nsubj|approach needs|nmod|patients patients|nmod|therapy therapy|compound|END_ENTITY	Mathematical approach for estimating iron needs in hemodialysis patients on erythropoietin therapy .
9175038	0	iron	18,22	erythropoietin	55,69	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|nmod|END_ENTITY	The management of iron metabolism in recombinant human erythropoietin treated dialysis patients by Dutch nephrologists .
9247776	0	iron	43,47	erythropoietin	109,123	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	therapy|compound|START_ENTITY effectiveness|nmod|therapy evaluation|nmod|effectiveness evaluation|acl|receiving receiving|dobj|END_ENTITY	An evaluation of the effectiveness of oral iron therapy in hemodialysis patients receiving recombinant human erythropoietin .
9247787	0	iron	37,41	erythropoietin	77,91	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	therapy|nmod|START_ENTITY therapy|acl|receiving receiving|dobj|END_ENTITY	Maintenance therapy with intravenous iron in hemodialysis patients receiving erythropoietin .
9266623	0	iron	16,20	erythropoietin	91,105	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	Availability|nmod|START_ENTITY modifies|nsubj|Availability modifies|nmod|END_ENTITY	Availability of iron and degree of inflammation modifies the response to recombinant human erythropoietin when treating anemia of chronic_disease in patients with rheumatoid_arthritis .
9266922	0	iron	26,30	erythropoietin	81,95	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|response response|nmod|END_ENTITY	The effect of intravenous iron on the reticulocyte response to recombinant human erythropoietin .
9360662	0	iron	14,18	erythropoietin	34,48	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	saturation|compound|START_ENTITY saturation|nmod|END_ENTITY	Importance of iron saturation for erythropoietin responsiveness in chronic peritoneal_dialysis .
9491286	0	iron	62,66	erythropoietin	133,147	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	response|nmod|START_ENTITY response|acl|functional functional|dep|receiving receiving|dobj|END_ENTITY	Comparative response to single or divided doses of parenteral iron for functional iron_deficiency in hemodialysis patients receiving erythropoietin -LRB- EPO -RRB- .
9579879	0	iron	35,39	erythropoietin	110,124	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	efficacy|nmod|START_ENTITY estimation|nmod|efficacy supplementation|nsubj|estimation supplementation|nmod|beta beta|appos|END_ENTITY	The estimation of efficacy of oral iron supplementation during treatment with epoetin beta -LRB- recombinant human erythropoietin -RRB- in patients undergoing cardiac surgery .
9756115	0	iron	57,61	erythropoietin	25,39	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	therapy|compound|START_ENTITY utilization|nmod|therapy utilization|nmod|END_ENTITY	Effective utilization of erythropoietin with intravenous iron therapy .
9784666	0	iron	84,88	erythropoietin	43,57	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	relevance|nmod|START_ENTITY Erythropoiesis|dep|relevance Erythropoiesis|nmod|patients patients|acl|stimulated stimulated|nmod|END_ENTITY	Erythropoiesis in patients stimulated with erythropoietin : the relevance of storage iron .
9807056	0	iron	21,25	erythropoietin	79,93	iron	erythropoietin	MESH:D007501	2056	Chemical	Gene	administration|compound|START_ENTITY treated|nsubj|administration treated|nmod|END_ENTITY	Intravenous low-dose iron administration in hemodialysis patients treated with erythropoietin .
10748212	0	iron	43,47	ferritin	74,82	iron	ferritin	MESH:D007501	547824(Tax:3847)	Chemical	Gene	element|compound|START_ENTITY element|nmod|gene gene|compound|END_ENTITY	Identification and characterization of the iron regulatory element in the ferritin gene of a plant -LRB- soybean -RRB- .
1547222	0	iron	4,8	ferritin	30,38	iron	ferritin	MESH:D007501	547824(Tax:3847)	Chemical	Gene	region|compound|START_ENTITY region|nmod|mRNA mRNA|compound|END_ENTITY	The iron regulatory region of ferritin mRNA is also a positive control element for iron-independent translation .
6602802	1	iron	100,104	ferritin	78,86	iron	ferritin	MESH:D007501	100127084(Tax:4565)	Chemical	Gene	synthesis|nmod|START_ENTITY synthesis|compound|END_ENTITY	Induction of ferritin synthesis by iron in liver as well as red cells combines high translational efficiency with increased utilization of preformed ferritin mRNA .
10903501	0	iron	70,74	ferrochelatase	38,52	iron	ferrochelatase	MESH:D007501	2235	Chemical	Gene	levels|compound|START_ENTITY Regulation|nmod|levels Regulation|nmod|expression expression|nmod|END_ENTITY	Regulation of the expression of human ferrochelatase by intracellular iron levels .
15123683	0	iron	18,22	ferrochelatase	35,49	iron	ferrochelatase	MESH:D007501	2235	Chemical	Gene	delivery|compound|START_ENTITY delivery|dep|END_ENTITY	Frataxin-mediated iron delivery to ferrochelatase in the final step of heme biosynthesis .
18044970	0	iron	56,60	ferrochelatase	15,29	iron	ferrochelatase	MESH:D007501	2235	Chemical	Gene	removal|nmod|START_ENTITY catalyzes|dobj|removal catalyzes|nsubj|Heme_synthase Heme_synthase|appos|END_ENTITY	Heme_synthase -LRB- ferrochelatase -RRB- catalyzes the removal of iron from heme and demetalation of metalloporphyrins .
19965627	0	iron	91,95	ferrochelatase	60,74	iron	ferrochelatase	MESH:D007501	2235	Chemical	Gene	availability|compound|START_ENTITY dependent|nmod|availability machinery|amod|dependent machinery|nsubj|stability stability|nmod|END_ENTITY	Posttranslational stability of the heme biosynthetic enzyme ferrochelatase is dependent on iron availability and intact iron-sulfur cluster assembly machinery .
208637	0	iron	39,43	ferrochelatase	51,65	iron	ferrochelatase	MESH:D007501	361338(Tax:10116)	Chemical	Gene	Studies|nmod|START_ENTITY Studies|nmod|reaction reaction|amod|END_ENTITY	Studies on the utilization of ferritin iron in the ferrochelatase reaction of isolated rat liver mitochondria .
3707999	0	iron	47,51	ferrochelatase	20,34	iron	ferrochelatase	MESH:D007501	14151(Tax:10090)	Chemical	Gene	content|compound|START_ENTITY activity|nmod|content activity|amod|END_ENTITY	Effect of decreased ferrochelatase activity on iron and porphyrin content in mitochondria of mice with porphyria induced by griseofulvin .
5431821	0	iron	32,36	ferrochelatase	68,82	iron	ferrochelatase	MESH:D007501	2235	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	-LSB- Effect of the concentration of iron and pyridoxal_phosphate on the ferrochelatase activity of erythrocytes -RSB- .
12091367	0	iron	39,43	ferroportin_1	99,112	iron	ferroportin 1	MESH:D007501	30061	Chemical	Gene	overload|compound|START_ENTITY overload|acl|associated associated|nmod|deletion deletion|nmod|gene gene|amod|END_ENTITY	Autosomal dominant reticuloendothelial iron overload associated with a 3-base pair deletion in the ferroportin_1 gene -LRB- SLC11A3 -RRB- .
12873829	0	iron	75,79	ferroportin_1	18,31	iron	ferroportin 1	MESH:D007501	30061	Chemical	Gene	overload|compound|START_ENTITY associated|nmod|overload associated|nsubjpass|mutation mutation|nmod|gene gene|amod|END_ENTITY	Novel mutation in ferroportin_1 gene is associated with autosomal dominant iron overload .
15084469	0	iron	69,73	ferroportin_1	14,27	iron	ferroportin 1	MESH:D007501	53945(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY alterations|nmod|homeostasis causes|dobj|alterations causes|nsubj|Disruption Disruption|nmod|regulation regulation|amod|END_ENTITY	Disruption of ferroportin_1 regulation causes dynamic alterations in iron homeostasis and erythropoiesis in polycythaemia mice .
18586980	0	iron	4,8	ferroportin_1	24,37	iron	ferroportin 1	MESH:D007501	53945(Tax:10090)	Chemical	Gene	export|nsubj|START_ENTITY export|ccomp|expressed expressed|nsubjpass|END_ENTITY	The iron export protein ferroportin_1 is differentially expressed in mouse macrophage populations and is present in the mycobacterial-containing phagosome .
18646536	0	iron	11,15	ferroportin_1	44,57	iron	ferroportin 1	MESH:D007501	30061	Chemical	Gene	status|compound|START_ENTITY Effect|nmod|status Effect|nmod|women women|nmod|expression expression|amod|END_ENTITY	-LSB- Effect of iron status of pregnant women on ferroportin_1 expression in third-trimester placenta -RSB- .
19027283	0	iron	4,8	ferroportin_1	45,58	iron	ferroportin 1	MESH:D007501	30061	Chemical	Gene	hepcidin|amod|START_ENTITY reduces|nsubj|hepcidin reduces|dobj|content content|amod|END_ENTITY	The iron regulatory hormone hepcidin reduces ferroportin_1 content and iron release in H9C2 cardiomyocytes .
19766498	0	iron	25,29	ferroportin_1	62,75	iron	ferroportin 1	MESH:D007501	170840(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY analysis|nmod|concentration analysis|nmod|END_ENTITY	Quantitative analysis of iron concentration and expression of ferroportin_1 in the cortex and hippocampus of rats induced by cerebral_ischemia .
22357659	0	iron	43,47	ferroportin_1	66,79	iron	ferroportin 1	MESH:D007501	30061	Chemical	Gene	transport|nsubj|START_ENTITY transport|dobj|END_ENTITY	Polymorphisms in the gene that encodes the iron transport protein ferroportin_1 influence susceptibility to tuberculosis .
24174620	0	iron	114,118	ferroportin_1	157,170	iron	ferroportin 1	MESH:D007501	170840(Tax:10116)	Chemical	Gene	flux|compound|START_ENTITY flux|nmod|induction induction|nmod|END_ENTITY	Silencing the Menkes copper-transporting ATPase -LRB- Atp7a -RRB- gene in rat intestinal epithelial -LRB- IEC-6 -RRB- cells increases iron flux via transcriptional induction of ferroportin_1 -LRB- Fpn1 -RRB- .
22889519	0	iron	76,80	fibrinogen	26,36	iron	fibrinogen	MESH:D007501	2244	Chemical	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Hydroxyl radical-modified fibrinogen as a marker of thrombosis : the role of iron .
23864430	0	iron	54,58	fibrinogen	37,47	iron	fibrinogen	MESH:D007501	2244	Chemical	Gene	analysis|nmod|START_ENTITY analysis|nmod|END_ENTITY	Functional binding analysis of human fibrinogen as an iron - and heme-binding protein .
11030757	0	iron	39,43	frataxin	6,14	iron	frataxin	MESH:D007501	2395	Chemical	Gene	homeostasis|compound|START_ENTITY maintains|dobj|homeostasis maintains|nsubj|END_ENTITY	Human frataxin maintains mitochondrial iron homeostasis in Saccharomyces_cerevisiae .
18425540	0	iron	8,12	frataxin	36,44	iron	frataxin	MESH:D007501	2395	Chemical	Gene	sites|compound|START_ENTITY sites|nmod|END_ENTITY	Mapping iron binding sites on human frataxin : implications for cluster assembly on the ISU_Fe-S cluster scaffold protein .
15067523	0	iron	15,19	glyoxalase_II	32,45	iron	glyoxalase II	MESH:D007501	820255(Tax:3702)	Chemical	Gene	The|nmod|START_ENTITY The|nmod|END_ENTITY	The binding of iron and zinc to glyoxalase_II occurs exclusively as di-metal centers and is unique within the metallo-beta-lactamase family .
19047680	0	iron	75,79	growth_differentiation_factor_15	14,46	iron	growth differentiation factor 15	MESH:D007501	9518	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of growth_differentiation_factor_15 expression by intracellular iron .
22983584	0	iron	74,78	growth_differentiation_factor_15	11,43	iron	growth differentiation factor 15	MESH:D007501	23886(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY essential|nmod|homeostasis essential|nsubj|END_ENTITY	The murine growth_differentiation_factor_15 is not essential for systemic iron homeostasis in phlebotomized mice .
21841538	0	iron	27,31	heme_oxygenase_1	118,134	iron	heme oxygenase 1	MESH:D007501	24451(Tax:10116)	Chemical	Gene	increase|nmod|START_ENTITY independent|nsubj|increase independent|nmod|upregulation upregulation|amod|END_ENTITY	Transient increase of free iron in rat livers following hemorrhagic-traumatic_shock and reperfusion is independent of heme_oxygenase_1 upregulation .
25239913	0	iron	120,124	hemeoxygenase-1	93,108	iron	hemeoxygenase-1	MESH:D007501	15368(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY homeostasis|amod|END_ENTITY	Impaired TLR4 and HIF expression in cystic_fibrosis bronchial epithelial cells downregulates hemeoxygenase-1 and alters iron homeostasis in vitro .
10492444	0	iron	84,88	hemoglobin	106,116	iron	hemoglobin	MESH:D007501	100323610(Tax:9823)	Chemical	Gene	effects|compound|START_ENTITY effects|nmod|END_ENTITY	Intensive indoor versus outdoor swine production systems : genotype and supplemental iron effects on blood hemoglobin and selected immune measures in young pigs .
15825077	0	iron	29,33	hephaestin	52,62	iron	hephaestin	MESH:D007501	9843	Chemical	Gene	protein|compound|START_ENTITY expression|nmod|protein END_ENTITY|nsubj|expression	CDX2-regulated expression of iron transport protein hephaestin in intestinal and colonic epithelium .
10692416	0	iron	65,69	interferon-gamma	11,27	iron	interferon-gamma	MESH:D007501	15978(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	Effects of interferon-gamma and lipopolysaccharide on macrophage iron metabolism are mediated by nitric_oxide-induced degradation of iron_regulatory_protein_2 .
18795672	0	iron	61,65	interferon-gamma	29,45	iron	interferon-gamma	MESH:D007501	3458	Chemical	Gene	chelation|compound|START_ENTITY enhanced|nmod|chelation enhanced|nsubjpass|effect effect|nmod|END_ENTITY	Anti-proliferative effect of interferon-gamma is enhanced by iron chelation in colon_cancer cell lines in vitro .
12881862	0	iron	15,19	interleukin-2	50,63	iron	interleukin-2	MESH:D007501	3558	Chemical	Gene	START_ENTITY|nmod|effect effect|nmod|END_ENTITY	-LSB- Modulation of iron on the vasodilating effect of interleukin-2 in the isolated aortic ring -RSB- .
15840341	0	iron	30,34	interleukin-2	13,26	iron	interleukin-2	MESH:D007501	100302458(Tax:9986)	Chemical	Gene	-RSB-|compound|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- The role of interleukin-2 in iron powder-induced intraocular_inflammation -RSB- .
20724768	0	iron	13,17	interleukin-2	28,41	iron	interleukin-2	MESH:D007501	3558	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of iron on plasma interleukin-2 and gamma interferon level in iron_deficiency_anemia .
8346713	0	iron	23,27	interleukin-2	59,72	iron	interleukin-2	MESH:D007501	3558	Chemical	Gene	metabolism|compound|START_ENTITY regulation|nmod|metabolism regulation|dep|effect effect|nmod|therapy therapy|compound|END_ENTITY	Cytokine regulation of iron metabolism : effect of low-dose interleukin-2 subcutaneous therapy on ferritin , transferrin and iron blood concentrations in cancer patients .
16221503	0	iron	90,94	interleukin-6	54,67	iron	interleukin-6	MESH:D007501	24498(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulatory effects of tumor_necrosis_factor-alpha and interleukin-6 on HAMP expression in iron loaded rat hepatocytes .
16351643	0	iron	58,62	interleukin-6	8,21	iron	interleukin-6	MESH:D007501	16193(Tax:10090)	Chemical	Gene	absorption|compound|START_ENTITY Role|nmod|absorption Role|nmod|END_ENTITY	Role of interleukin-6 in hypoxic regulation of intestinal iron absorption .
9600219	0	iron	9,13	interleukin-6	90,103	iron	interleukin-6	MESH:D007501	16193(Tax:10090)	Chemical	Gene	deposition|compound|START_ENTITY associated|nsubj|deposition associated|nmod|transgenic_mice transgenic_mice|acl|expressing expressing|xcomp|END_ENTITY	Abnormal iron deposition associated with lipid peroxidation in transgenic_mice expressing interleukin-6 in the brain .
11175792	0	iron	89,93	iron_regulatory_protein-2	39,64	iron	iron regulatory protein-2	MESH:D007501	64602(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY misregulation|nmod|metabolism causes|dobj|misregulation causes|nsubj|deletion deletion|nmod|END_ENTITY	Targeted deletion of the gene encoding iron_regulatory_protein-2 causes misregulation of iron metabolism and neurodegenerative_disease in mice .
22093897	0	iron	51,55	iron_regulatory_protein-2	22,47	iron	iron regulatory protein-2	MESH:D007501	3658	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	-LSB- Regulating action of iron_regulatory_protein-2 in iron metabolism of lung_cancer -RSB- .
9914507	0	iron	104,108	iron_regulatory_protein-2	27,52	iron	iron regulatory protein-2	MESH:D007501	64831(Tax:10116)	Chemical	Gene	sensitivity|nmod|START_ENTITY result|nmod|sensitivity activation|nmod|result activation|nmod|lines lines|amod|END_ENTITY	Preferential activation of iron_regulatory_protein-2 in cell lines as a result of higher sensitivity to iron .
11023790	0	iron	14,18	lactoferrin	32,43	iron	lactoferrin	MESH:D007501	280846(Tax:9913)	Chemical	Gene	release|compound|START_ENTITY release|nmod|END_ENTITY	Transferrins : iron release from lactoferrin .
12461085	0	iron	18,22	lactoferrin	80,91	iron	lactoferrin	MESH:D007501	17002(Tax:10090)	Chemical	Gene	defect|compound|START_ENTITY defect|nmod|mice mice|nmod|END_ENTITY	Correction of the iron overload defect in beta-2-microglobulin knockout mice by lactoferrin abolishes their increased susceptibility to tuberculosis .
15905437	0	iron	67,71	lactoferrin	33,44	iron	lactoferrin	MESH:D007501	17002(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Developmental gene expression of lactoferrin and effect of dietary iron on gene regulation of lactoferrin in mouse mammary gland .
15905437	0	iron	67,71	lactoferrin	94,105	iron	lactoferrin	MESH:D007501	17002(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Developmental gene expression of lactoferrin and effect of dietary iron on gene regulation of lactoferrin in mouse mammary gland .
16936810	0	iron	72,76	lactoferrin	23,34	iron	lactoferrin	MESH:D007501	280846(Tax:9913)	Chemical	Gene	increases|dobj|START_ENTITY increases|nsubj|administration administration|nmod|END_ENTITY	Oral administration of lactoferrin increases hemoglobin and total serum iron in pregnant women .
20170734	0	iron	88,92	lactoferrin	124,135	iron	lactoferrin	MESH:D007501	280846(Tax:9913)	Chemical	Gene	retain|dobj|START_ENTITY retain|nmod|pH pH|appos|feature feature|nmod|END_ENTITY	Seminal plasma of brown trout , Salmo trutta fario -LRB- L. -RRB- contains a factor able to retain iron at acid pH , typical feature of lactoferrin .
23164231	0	iron	10,14	lactoferrin	35,46	iron	lactoferrin	MESH:D007501	17002(Tax:10090)	Chemical	Gene	level|compound|START_ENTITY level|nmod|END_ENTITY	Effect of iron saturation level of lactoferrin on osteogenic activity in vitro and in vivo .
23604471	0	iron	51,55	lactoferrin	70,81	iron	lactoferrin	MESH:D007501	280846(Tax:9913)	Chemical	Gene	saturation|compound|START_ENTITY quantification|nmod|saturation method|nmod|quantification method|nmod|preparations preparations|compound|END_ENTITY	A high-throughput method for the quantification of iron saturation in lactoferrin preparations .
24444915	0	iron	57,61	lactoferrin	89,100	iron	lactoferrin	MESH:D007501	280846(Tax:9913)	Chemical	Gene	level|compound|START_ENTITY level|nmod|END_ENTITY	Evaluation of different methods for determination of the iron saturation level in bovine lactoferrin .
26035688	0	iron	111,115	lactoferrin	25,36	iron	lactoferrin	MESH:D007501	17002(Tax:10090)	Chemical	Gene	ability|compound|START_ENTITY connected|nmod|ability connected|nsubjpass|effect effect|nmod|END_ENTITY	The protective effect of lactoferrin on ventral mesencephalon neurons against MPP -LRB- + -RRB- is not connected with its iron binding ability .
3421902	0	iron	23,27	lactoferrin	46,57	iron	lactoferrin	MESH:D007501	17002(Tax:10090)	Chemical	Gene	Uptake|nmod|START_ENTITY Uptake|nmod|complexes complexes|compound|END_ENTITY	Uptake and handling of iron from transferrin , lactoferrin and immune complexes by a macrophage cell line .
6644450	0	iron	112,116	lactoferrin	43,54	iron	lactoferrin	MESH:D007501	17002(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Supplementation|dep|Effects Supplementation|nmod|milk milk|nmod|iron iron|acl|bound bound|xcomp|END_ENTITY	Supplementation of milk with iron bound to lactoferrin using weanling mice : L. Effects on hematology and tissue iron .
6644450	0	iron	29,33	lactoferrin	43,54	iron	lactoferrin	MESH:D007501	17002(Tax:10090)	Chemical	Gene	START_ENTITY|acl|bound bound|xcomp|END_ENTITY	Supplementation of milk with iron bound to lactoferrin using weanling mice : L. Effects on hematology and tissue iron .
6707846	0	iron	29,33	lactoferrin	43,54	iron	lactoferrin	MESH:D007501	17002(Tax:10090)	Chemical	Gene	milk|nmod|START_ENTITY Supplementation|nmod|milk bound|nsubj|Supplementation bound|xcomp|END_ENTITY	Supplementation of milk with iron bound to lactoferrin using weanling mice .
7394833	0	iron	22,26	lactoferrin	92,103	iron	lactoferrin	MESH:D007501	280846(Tax:9913)	Chemical	Gene	metabolism|compound|START_ENTITY Relationships|nmod|metabolism Relationships|dep|association association|nmod|vanadium vanadium|nmod|END_ENTITY	Relationships between iron and vanadium metabolism : the association of vanadium with bovine lactoferrin .
7487902	0	iron	33,37	lactoferrin	43,54	iron	lactoferrin	MESH:D007501	301034(Tax:10116)	Chemical	Gene	acquire|dobj|START_ENTITY acquire|nmod|END_ENTITY	Isolated rat hepatocytes acquire iron from lactoferrin by endocytosis .
8576812	0	iron	132,136	lactoferrin	34,45	iron	lactoferrin	MESH:D007501	280846(Tax:9913)	Chemical	Gene	absorption|nmod|START_ENTITY studies|nmod|absorption model|nmod|studies Receptor-mediated|dep|model Receptor-mediated|nmod|END_ENTITY	Receptor-mediated binding of milk lactoferrin to nursing piglet enterocytes : a model for studies on absorption of lactoferrin-bound iron .
8708108	0	iron	48,52	lactoferrin	23,34	iron	lactoferrin	MESH:D007501	280846(Tax:9913)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of supplemental lactoferrin with ferrous iron on iron status of newborn calves .
8708108	0	iron	56,60	lactoferrin	23,34	iron	lactoferrin	MESH:D007501	280846(Tax:9913)	Chemical	Gene	status|compound|START_ENTITY iron|nmod|status Effect|nmod|iron Effect|nmod|END_ENTITY	Effect of supplemental lactoferrin with ferrous iron on iron status of newborn calves .
9652407	0	iron	30,34	lactoferrin	45,56	iron	lactoferrin	MESH:D007501	280846(Tax:9913)	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|END_ENTITY	Transferrins -- a mechanism for iron uptake by lactoferrin .
2164931	0	iron	36,40	lipoxygenase	56,68	iron	lipoxygenase	MESH:D007501	547836(Tax:3847)	Chemical	Gene	environment|compound|START_ENTITY environment|nmod|END_ENTITY	The initial characterization of the iron environment in lipoxygenase by M ssbauer spectroscopy .
8626476	0	iron	36,40	lipoxygenase	23,35	iron	lipoxygenase	MESH:D007501	547836(Tax:3847)	Chemical	Gene	site|compound|START_ENTITY site|compound|END_ENTITY	The environment of the lipoxygenase iron binding site explored with novel hydroxypyridinone_iron chelators .
7999760	0	iron	26,30	lipoxygenase-1	47,61	iron	lipoxygenase-1	MESH:D007501	547923(Tax:3847)	Chemical	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	X-ray spectroscopy of the iron site in soybean lipoxygenase-1 : changes in coordination upon oxidation or addition of methanol .
8518276	0	iron	50,54	lipoxygenase_L-1	82,98	iron	lipoxygenase L-1	MESH:D007501	547923(Tax:3847)	Chemical	Gene	determination|nmod|START_ENTITY determination|nmod|END_ENTITY	Crystallographic determination of the active site iron and its ligands in soybean lipoxygenase_L-1 .
818893	0	iron	5,9	man_II	24,30	iron	man II	MESH:D007501	4124	Chemical	Gene	absorption|compound|START_ENTITY absorption|nmod|END_ENTITY	Food iron absorption in man_II .
18760346	0	iron	65,69	manganese_superoxide_dismutase	4,34	iron	manganese superoxide dismutase	MESH:D007501	6648	Chemical	Gene	accumulation|compound|START_ENTITY modulates|dobj|accumulation modulates|nsubj|dimorphism dimorphism|amod|END_ENTITY	The manganese_superoxide_dismutase Ala16Val dimorphism modulates iron accumulation in human hepatoma cells .
18523150	0	iron	83,87	matriptase-2	31,43	iron	matriptase-2	MESH:D007501	71753(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY regulator|nmod|homeostasis regulator|nsubj|END_ENTITY	Membrane-bound serine protease matriptase-2 -LRB- Tmprss6 -RRB- is an essential regulator of iron homeostasis .
19386032	0	iron	35,39	matriptase-2	71,83	iron	matriptase-2	MESH:D007501	164656	Chemical	Gene	hormone|compound|START_ENTITY hormone|acl|hepcidin hepcidin|advcl|END_ENTITY	Into the matrix : regulation of the iron regulatory hormone hepcidin by matriptase-2 .
19907145	0	iron	34,38	matriptase-2	8,20	iron	matriptase-2	MESH:D007501	164656	Chemical	Gene	metabolism|compound|START_ENTITY Role|nmod|metabolism Role|nmod|END_ENTITY	Role of matriptase-2 -LRB- TMPRSS6 -RRB- in iron metabolism .
25550162	0	iron	18,22	matriptase-2	50,62	iron	matriptase-2	MESH:D007501	164656	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|stability stability|nmod|END_ENTITY	Low intracellular iron increases the stability of matriptase-2 .
15670845	0	iron	41,45	megalin	23,30	iron	megalin	MESH:D007501	4036	Chemical	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	The endocytic receptor megalin binds the iron transporting neutrophil-gelatinase-associated_lipocalin with high affinity and mediates its cellular uptake .
10691965	0	iron	75,79	melanotransferrin	47,64	iron	melanotransferrin	MESH:D007501	4241	Chemical	Gene	uptake|compound|START_ENTITY role|nmod|uptake role|nmod|antigen antigen|appos|END_ENTITY	The role of the membrane-bound tumour antigen , melanotransferrin -LRB- p97 -RRB- , in iron uptake by the human malignant_melanoma cell .
11033347	0	iron	77,81	melanotransferrin	41,58	iron	melanotransferrin	MESH:D007501	4241	Chemical	Gene	transport|compound|START_ENTITY roles|nmod|transport END_ENTITY|dep|roles	The membrane-bound transferrin homologue melanotransferrin : roles other than iron transport ?
12230555	0	iron	103,107	melanotransferrin	62,79	iron	melanotransferrin	MESH:D007501	4241	Chemical	Gene	donates|dobj|START_ENTITY donates|nsubj|form form|nmod|homologue homologue|appos|END_ENTITY	The soluble form of the membrane-bound transferrin homologue , melanotransferrin , inefficiently donates iron to cells via nonspecific internalization and degradation of the protein .
16291590	0	iron	29,33	melanotransferrin	8,25	iron	melanotransferrin	MESH:D007501	30060(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	Role of melanotransferrin in iron metabolism : studies using targeted gene disruption in vivo .
17452986	0	iron	78,82	melanotransferrin	28,45	iron	melanotransferrin	MESH:D007501	30060(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY hallmark|nmod|metabolism END_ENTITY|dep|hallmark	The melanoma_tumor antigen , melanotransferrin -LRB- p97 -RRB- : a 25-year hallmark -- from iron metabolism to tumorigenesis .
21364282	0	iron	54,58	miR-122	28,35	iron	miR-122	MESH:D007501	387231(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY controls|dobj|homeostasis controls|nsubj|END_ENTITY	The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice .
15543948	0	iron	14,18	mitochondrial_aconitase	22,45	iron	mitochondrial aconitase	MESH:D007501	50	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|expression expression|amod|END_ENTITY	Modulation of iron on mitochondrial_aconitase expression in human prostatic_carcinoma cells .
16757684	0	iron	47,51	mitochondrial_ferritin	92,114	iron	mitochondrial ferritin	MESH:D007501	94033	Chemical	Gene	deprivation|compound|START_ENTITY deprivation|acl|caused caused|nmod|expression expression|nmod|END_ENTITY	In vivo tumor growth is inhibited by cytosolic iron deprivation caused by the expression of mitochondrial_ferritin .
24065548	0	iron	57,61	mitochondrial_ferritin	21,43	iron	mitochondrial ferritin	MESH:D007501	94033	Chemical	Gene	dysregulation|compound|START_ENTITY END_ENTITY|nmod|dysregulation	Protective effect of mitochondrial_ferritin on cytosolic iron dysregulation induced by doxorubicin in HeLa cells .
1983814	0	iron	48,52	mucin	11,16	iron	mucin	MESH:D007501	65202(Tax:10116)	Chemical	Gene	absorption|nmod|START_ENTITY role|nmod|absorption role|nmod|END_ENTITY	A role for mucin in the absorption of inorganic iron and other metal cations .
2542309	0	iron	28,32	myeloperoxidase	68,83	iron	myeloperoxidase	MESH:D007501	4353	Chemical	Gene	capacity|compound|START_ENTITY capacity|nmod|system system|compound|END_ENTITY	Inactivation of transferrin iron binding capacity by the neutrophil myeloperoxidase system .
14551810	0	iron	26,30	nFbp	81,85	iron	nFbp	MESH:D007501	22984	Chemical	Gene	release|compound|START_ENTITY release|nmod|END_ENTITY	Kinetics and mechanism of iron release from the bacterial ferric binding protein nFbp : exogenous anion influence and comparison with mammalian transferrin .
15105273	0	iron	70,74	pantothenate_kinase-associated_neurodegeneration	91,139	iron	pantothenate kinase-associated neurodegeneration	MESH:D007501	80025	Chemical	Gene	accumulation|compound|START_ENTITY accumulation|nmod|END_ENTITY	Mitochondrial localization of human PANK2 and hypotheses of secondary iron accumulation in pantothenate_kinase-associated_neurodegeneration .
10037716	0	iron	21,25	phenylalanine_hydroxylase	66,91	iron	phenylalanine hydroxylase	MESH:D007501	5053	Chemical	Gene	accessibility|nmod|START_ENTITY END_ENTITY|nsubj|accessibility	The accessibility of iron at the active site of recombinant human phenylalanine_hydroxylase to water as studied by 1H NMR paramagnetic relaxation .
12696880	0	iron	159,163	phenylalanine_hydroxylase	41,66	iron	phenylalanine hydroxylase	MESH:D007501	5053	Chemical	Gene	sphere|nmod|START_ENTITY self-repair|nmod|sphere example|nmod|self-repair example|nsubj|hydroxylation hydroxylation|nmod|END_ENTITY	Posttranslational hydroxylation of human phenylalanine_hydroxylase is a novel example of enzyme self-repair within the second coordination sphere of catalytic iron .
15917086	0	iron	48,52	phenylalanine_hydroxylase	94,119	iron	phenylalanine hydroxylase	MESH:D007501	5053	Chemical	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	The active site residue tyrosine 325 influences iron binding and coupling efficiency in human phenylalanine_hydroxylase .
1646718	0	iron	57,61	phenylalanine_hydroxylase	84,109	iron	phenylalanine hydroxylase	MESH:D007501	510583(Tax:9913)	Chemical	Gene	studies|nmod|START_ENTITY studies|nmod|site site|nmod|END_ENTITY	EPR and 1H-NMR spectroscopic studies on the paramagnetic iron at the active site of phenylalanine_hydroxylase and its interaction with substrates and inhibitors .
16676991	0	iron	132,136	phenylalanine_hydroxylase	64,89	iron	phenylalanine hydroxylase	MESH:D007501	5053	Chemical	Gene	environment|compound|START_ENTITY effects|nmod|environment studies|dep|effects studies|nmod|adducts adducts|nmod|END_ENTITY	EPR and UV-vis studies of the nitric_oxide adducts of bacterial phenylalanine_hydroxylase : effects of cofactor and substrate on the iron environment .
16034168	0	iron	113,117	phosvitin	30,39	iron	phosvitin	MESH:D007501	13001(Tax:10090)	Chemical	Gene	ions|compound|START_ENTITY presence|nmod|ions peroxidation|nmod|presence effect|dep|peroxidation effect|nmod|END_ENTITY	Protective effect of egg yolk phosvitin against ultraviolet - light-induced lipid peroxidation in the presence of iron ions .
3006970	0	iron	126,130	phosvitin	113,122	iron	phosvitin	MESH:D007501	1460	Chemical	Gene	mobilization|compound|START_ENTITY END_ENTITY|nmod|mobilization	Potential role of in vitro iron bioavailability studies in combatting iron_deficiency : a study of the effects of phosvitin on iron mobilization from pinto beans .
3006970	0	iron	27,31	phosvitin	113,122	iron	phosvitin	MESH:D007501	1460	Chemical	Gene	studies|compound|START_ENTITY role|nmod|studies role|dep|study study|nmod|effects effects|nmod|END_ENTITY	Potential role of in vitro iron bioavailability studies in combatting iron_deficiency : a study of the effects of phosvitin on iron mobilization from pinto beans .
3711888	0	iron	106,110	phosvitin	16,25	iron	phosvitin	MESH:D007501	1460	Chemical	Gene	sites|compound|START_ENTITY saturation|nmod|sites degree|nmod|saturation function|nmod|degree release|nmod|function rate|nmod|release variation|nmod|rate binding|dep|variation binding|nmod|END_ENTITY	Iron binding by phosvitin : variation of rate of iron release as a function of the degree of saturation of iron binding sites .
3711888	0	iron	48,52	phosvitin	16,25	iron	phosvitin	MESH:D007501	1460	Chemical	Gene	release|compound|START_ENTITY rate|nmod|release variation|nmod|rate binding|dep|variation binding|nmod|END_ENTITY	Iron binding by phosvitin : variation of rate of iron release as a function of the degree of saturation of iron binding sites .
24916507	0	iron	11,15	placenta_growth_factor	26,48	iron	placenta growth factor	MESH:D007501	5228	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Heme-bound iron activates placenta_growth_factor in erythroid cells via erythroid Kr ppel-like factor .
20638487	0	iron	53,57	prohibitin	36,46	iron	prohibitin	MESH:D007501	5245	Chemical	Gene	protein|amod|START_ENTITY protein|nsubj|END_ENTITY	Nuclear coded mitochondrial protein prohibitin is an iron regulated iron binding protein .
20638487	0	iron	68,72	prohibitin	36,46	iron	prohibitin	MESH:D007501	5245	Chemical	Gene	protein|compound|START_ENTITY protein|nsubj|END_ENTITY	Nuclear coded mitochondrial protein prohibitin is an iron regulated iron binding protein .
24765096	0	iron	27,31	reductase	32,41	iron	reductase	MESH:D007501	547911(Tax:3847)	Chemical	Gene	Evaluation|nmod|START_ENTITY END_ENTITY|nsubj|Evaluation	Evaluation of constitutive iron reductase -LRB- AtFRO2 -RRB- expression on mineral accumulation and distribution in soybean -LRB- Glycine max .
180329	0	iron	80,84	sex-linked_anemia	103,120	iron	sex-linked anemia	MESH:D007501	15203(Tax:10090)	Chemical	Gene	stores|compound|START_ENTITY stores|nmod|END_ENTITY	Uptake of circulating iron by the duodenum of normal mice and mice with altered iron stores , including sex-linked_anemia : high resolution radioautographic study .
19828447	0	iron	14,18	time_for_coffee	78,93	iron	time for coffee	MESH:D007501	821807(Tax:3702)	Chemical	Gene	Regulation|nmod|START_ENTITY homeostasis|nsubj|Regulation homeostasis|nmod|END_ENTITY	Regulation of iron homeostasis in Arabidopsis_thaliana by the clock regulator time_for_coffee .
100104	0	iron	36,40	transferrin	63,74	iron	transferrin	MESH:D007501	7018	Chemical	Gene	donors|compound|START_ENTITY donors|nmod|END_ENTITY	Studies of the binding of different iron donors to human serum transferrin and isolation of iron-binding fragments from the N - and C-terminal regions of the protein .
10049947	0	iron	4,8	transferrin	93,104	iron	transferrin	MESH:D007501	7018	Chemical	Gene	NRAMP2|compound|START_ENTITY glycoprotein|nsubj|NRAMP2 glycoprotein|acl:relcl|colocalizes colocalizes|nmod|END_ENTITY	The iron transport protein NRAMP2 is an integral membrane glycoprotein that colocalizes with transferrin in recycling endosomes .
10367478	0	iron	52,56	transferrin	9,20	iron	transferrin	MESH:D007501	7018	Chemical	Gene	repletion|compound|START_ENTITY marker|nmod|repletion marker|nsubj|receptor receptor|compound|END_ENTITY	Is serum transferrin receptor a sensitive marker of iron repletion in patients with iron-deficiency_anemia and hemodialysis patients ?
10393220	0	iron	18,22	transferrin	45,56	iron	transferrin	MESH:D007501	7018	Chemical	Gene	release|compound|START_ENTITY release|nmod|END_ENTITY	Lipolysis-induced iron release from diferric transferrin : Possible role of lipoprotein_lipase in LDL oxidation .
10469492	0	iron	40,44	transferrin	76,87	iron	transferrin	MESH:D007501	7018	Chemical	Gene	Quantification|nmod|START_ENTITY Quantification|nmod|presence presence|nmod|END_ENTITY	Quantification of non-transferrin-bound iron in the presence of unsaturated transferrin .
10572108	0	iron	18,22	transferrin	35,46	iron	transferrin	MESH:D007501	7018	Chemical	Gene	uptake|compound|START_ENTITY downregulates|dobj|uptake downregulates|nmod|END_ENTITY	HFE downregulates iron uptake from transferrin and induces iron-regulatory protein activity in stably transfected cells .
10604284	0	iron	178,182	transferrin	41,52	iron	transferrin	MESH:D007501	7018	Chemical	Gene	function|nmod|START_ENTITY reported|nmod|function reported|nsubjpass|Alteration Alteration|nmod|spectrum spectrum|nmod|END_ENTITY	Alteration of infrared spectrum of serum transferrin by iron binding and lowered pH. Difference infrared spectra are reported for human serum transferrin in D2O as a function of iron binding or increased acidity .
10660486	0	iron	43,47	transferrin	14,25	iron	transferrin	MESH:D007501	7018	Chemical	Gene	metabolism|compound|START_ENTITY polymorphisms|nmod|metabolism polymorphisms|nsubj|effect effect|nmod|END_ENTITY	The effect of transferrin polymorphisms on iron metabolism .
10684598	0	iron	16,20	transferrin	66,77	iron	transferrin	MESH:D007501	7018	Chemical	Gene	Mutation|nmod|START_ENTITY ligand|nsubj|Mutation ligand|ccomp|abolishes abolishes|nsubj|His_249_to_Glu His_249_to_Glu|nmod|N-lobe N-lobe|nmod|END_ENTITY	Mutation of the iron ligand His_249_to_Glu in the N-lobe of human transferrin abolishes the dilysine `` trigger '' but does not significantly affect iron release .
10693977	0	iron	52,56	transferrin	31,42	iron	transferrin	MESH:D007501	24825(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY mediated|dobj|uptake mediated|nsubj|uptake uptake|nmod|END_ENTITY	Aluminum uptake and effects on transferrin mediated iron uptake in primary cultures of rat neurons , astrocytes and oligodendrocytes .
10739246	0	iron	112,116	transferrin	72,83	iron	transferrin	MESH:D007501	7018	Chemical	Gene	affinity|nmod|START_ENTITY structures|nmod|affinity structures|nmod|END_ENTITY	Crystal structures of two mutants -LRB- K206Q , H207E -RRB- of the N-lobe of human transferrin with increased affinity for iron .
10865941	0	iron	20,24	transferrin	37,48	iron	transferrin	MESH:D007501	22041(Tax:10090)	Chemical	Gene	Characterization|nmod|START_ENTITY uptake|nsubj|Characterization uptake|nmod|END_ENTITY	Characterization of iron uptake from transferrin by murine endothelial cells .
10910932	0	iron	45,49	transferrin	33,44	iron	transferrin	MESH:D007501	7018	Chemical	Gene	accumulation|compound|START_ENTITY accumulation|compound|END_ENTITY	Wild-type HFE protein normalizes transferrin iron accumulation in macrophages from subjects with hereditary_hemochromatosis .
10945243	0	iron	63,67	transferrin	80,91	iron	transferrin	MESH:D007501	22041(Tax:10090)	Chemical	Gene	nitrogen_monoxide|nmod|START_ENTITY action|nmod|nitrogen_monoxide mechanism|nmod|action Examination|nmod|mechanism uptake|nsubj|Examination uptake|nmod|END_ENTITY	Examination of the mechanism of action of nitrogen_monoxide on iron uptake from transferrin .
10970808	0	iron	75,79	transferrin	103,114	iron	transferrin	MESH:D007501	7018	Chemical	Gene	release|compound|START_ENTITY rate|nmod|release determining|dobj|rate determining|nmod|N-lobe N-lobe|compound|END_ENTITY	The chloride effect is related to anion binding in determining the rate of iron release from the human transferrin N-lobe .
11029429	0	iron	61,65	transferrin	106,117	iron	transferrin	MESH:D007501	7018	Chemical	Gene	supplies|dobj|START_ENTITY supplies|nmod|presence presence|nmod|END_ENTITY	The mammalian neuroendocrine hormone norepinephrine supplies iron for bacterial growth in the presence of transferrin or lactoferrin .
11033347	0	iron	77,81	transferrin	19,30	iron	transferrin	MESH:D007501	7018	Chemical	Gene	transport|compound|START_ENTITY roles|nmod|transport melanotransferrin|dep|roles melanotransferrin|compound|END_ENTITY	The membrane-bound transferrin homologue melanotransferrin : roles other than iron transport ?
11040982	0	iron	12,16	transferrin	27,38	iron	transferrin	MESH:D007501	7018	Chemical	Gene	Release|nmod|START_ENTITY ions|nsubj|Release ions|nmod|END_ENTITY	-LSB- Release of iron ions from transferrin under the effect of nitric_oxide -RSB- .
11335103	0	iron	141,145	transferrin	43,54	iron	transferrin	MESH:D007501	7018	Chemical	Gene	process|compound|START_ENTITY examination|nmod|process cells|dep|examination uptake|nmod|cells uptake|nmod|END_ENTITY	Iron and gallium increase iron uptake from transferrin by human melanoma cells : further examination of the ferric_ammonium_citrate-activated iron uptake process .
11500065	0	iron	137,141	transferrin	21,32	iron	transferrin	MESH:D007501	7018	Chemical	Gene	homeostasis|compound|START_ENTITY implications|nmod|homeostasis Polymorphisms|dep|implications Polymorphisms|nmod|region region|compound|END_ENTITY	Polymorphisms in the transferrin 5 ' flanking region associated with differences in total iron binding capacity : possible implications in iron homeostasis .
11500065	0	iron	89,93	transferrin	21,32	iron	transferrin	MESH:D007501	7018	Chemical	Gene	capacity|compound|START_ENTITY differences|nmod|capacity associated|nmod|differences region|acl|associated region|compound|END_ENTITY	Polymorphisms in the transferrin 5 ' flanking region associated with differences in total iron binding capacity : possible implications in iron homeostasis .
11570867	0	iron	133,137	transferrin	24,35	iron	transferrin	MESH:D007501	7018	Chemical	Gene	model|nmod|START_ENTITY N-lobe|nmod|model mutant|nmod|N-lobe structure|nmod|mutant variation|dep|structure variation|nmod|family family|compound|END_ENTITY	Ligand variation in the transferrin family : the crystal structure of the H249Q mutant of the human transferrin N-lobe as a model for iron binding in insect transferrins .
11570867	0	iron	133,137	transferrin	99,110	iron	transferrin	MESH:D007501	7018	Chemical	Gene	model|nmod|START_ENTITY N-lobe|nmod|model N-lobe|compound|END_ENTITY	Ligand variation in the transferrin family : the crystal structure of the H249Q mutant of the human transferrin N-lobe as a model for iron binding in insect transferrins .
11703331	0	iron	52,56	transferrin	6,17	iron	transferrin	MESH:D007501	7018	Chemical	Gene	anaemia|compound|START_ENTITY factor|nmod|anaemia mutation|dep|factor mutation|compound|END_ENTITY	Human transferrin G277S mutation : a risk factor for iron deficiency anaemia .
1176811	2	iron	121,125	transferrin	93,104	iron	transferrin	MESH:D007501	24825(Tax:10116)	Chemical	Gene	saturation|compound|START_ENTITY Studies|nmod|saturation Studies|nmod|END_ENTITY	Studies of transferrin at high and low iron saturation .
1180419	0	iron	24,28	transferrin	64,75	iron	transferrin	MESH:D007501	7018	Chemical	Gene	Determination|nmod|START_ENTITY Determination|nmod|END_ENTITY	-LSB- Determination of blood iron and the total fixation capacity of transferrin by a simple automatic technic without dialysis -RSB- .
12055114	0	iron	79,83	transferrin	31,42	iron	transferrin	MESH:D007501	7018	Chemical	Gene	status|compound|START_ENTITY Effects|nmod|status Effects|nmod|receptor receptor|compound|END_ENTITY	Effects of exercise on soluble transferrin receptor and other variables of the iron status .
12106773	0	iron	54,58	transferrin	39,50	iron	transferrin	MESH:D007501	22041(Tax:10090)	Chemical	Gene	distribution|compound|START_ENTITY Influence|nmod|distribution Influence|nmod|END_ENTITY	Influence of iron-saturation of plasma transferrin in iron distribution in the brain .
12136950	0	iron	18,22	transferrin	42,53	iron	transferrin	MESH:D007501	7018	Chemical	Gene	saturation|compound|START_ENTITY saturation|dep|END_ENTITY	Lymphocyte labile iron pool , plasma iron , transferrin saturation and ferritin levels in colon_cancer patients .
12136950	0	iron	36,40	transferrin	42,53	iron	transferrin	MESH:D007501	7018	Chemical	Gene	saturation|compound|START_ENTITY saturation|dep|END_ENTITY	Lymphocyte labile iron pool , plasma iron , transferrin saturation and ferritin levels in colon_cancer patients .
12165535	0	iron	26,30	transferrin	48,59	iron	transferrin	MESH:D007501	7018	Chemical	Gene	acquisition|compound|START_ENTITY metal-induced|dobj|acquisition metal-induced|nmod|END_ENTITY	Multivalent metal-induced iron acquisition from transferrin and lactoferrin by myeloid cells .
12230555	0	iron	103,107	transferrin	39,50	iron	transferrin	MESH:D007501	7018	Chemical	Gene	donates|dobj|START_ENTITY donates|nsubj|form form|nmod|homologue homologue|compound|END_ENTITY	The soluble form of the membrane-bound transferrin homologue , melanotransferrin , inefficiently donates iron to cells via nonspecific internalization and degradation of the protein .
12236996	0	iron	92,96	transferrin	71,82	iron	transferrin	MESH:D007501	22041(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY Influence|appos|uptake Influence|amod|binding binding|amod|END_ENTITY	-LSB- Influence of adjuvants on the ability of anti-Tbp antibodies to block transferrin binding , iron uptake and growth of Neisseria meningitis -RSB- .
12458193	0	iron	50,54	transferrin	94,105	iron	transferrin	MESH:D007501	7018	Chemical	Gene	release|compound|START_ENTITY rate|nmod|release controls|dobj|rate controls|nmod|N-lobe N-lobe|nmod|END_ENTITY	The position of arginine 124 controls the rate of iron release from the N-lobe of human serum transferrin .
12486226	0	iron	23,27	transferrin	54,65	iron	transferrin	MESH:D007501	7018	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding and release of iron by gel-encapsulated human transferrin : evidence for a conformational search .
12646708	0	iron	42,46	transferrin	96,107	iron	transferrin	MESH:D007501	7018	Chemical	Gene	anion|nmod|START_ENTITY influence|nmod|anion chelation|nsubj|influence chelation|nmod|protein protein|appos|END_ENTITY	The influence of the synergistic anion on iron chelation by ferric binding protein , a bacterial transferrin .
12667060	0	iron	34,38	transferrin	78,89	iron	transferrin	MESH:D007501	7018	Chemical	Gene	release|compound|START_ENTITY release|nmod|C-lobe C-lobe|nmod|END_ENTITY	Investigation of the mechanism of iron release from the C-lobe of human serum transferrin : mutational analysis of the role of a pH sensitive triad .
12755791	0	iron	80,84	transferrin	22,33	iron	transferrin	MESH:D007501	7018	Chemical	Gene	stores|compound|START_ENTITY absence|nmod|stores diagnostic|nmod|absence diagnostic|nsubj|value value|nmod|receptor receptor|compound|END_ENTITY	Single value of serum transferrin receptor is not diagnostic for the absence of iron stores in anaemic patients with rheumatoid_arthritis .
12801838	0	iron	65,69	transferrin	136,147	iron	transferrin	MESH:D007501	7018	Chemical	Gene	beta-thalassemia|compound|START_ENTITY activity|nmod|beta-thalassemia heterozygotes|nsubj|activity heterozygotes|advcl|reflected reflected|nmod|receptor receptor|compound|END_ENTITY	Erythroid bone marrow activity and red cell hemoglobinization in iron sufficient beta-thalassemia heterozygotes as reflected by soluble transferrin receptor and reticulocyte hemoglobin in content .
12867292	0	iron	17,21	transferrin	67,78	iron	transferrin	MESH:D007501	7018	Chemical	Gene	influence|nmod|START_ENTITY influence|nmod|concentration concentration|compound|END_ENTITY	The influence of iron , vitamin_B -LRB- 12 -RRB- , and folate levels on soluble transferrin receptor concentration in pregnant women .
12941522	0	iron	153,157	transferrin	141,152	iron	transferrin	MESH:D007501	7018	Chemical	Gene	uptake|compound|START_ENTITY uptake|compound|END_ENTITY	Over-expression of wild-type and mutant HFE in a human melanocytic cell line reveals an intracellular bridge between MHC class I pathway and transferrin iron uptake .
1338510	0	iron	46,50	transferrin	21,32	iron	transferrin	MESH:D007501	7018	Chemical	Gene	state|compound|START_ENTITY receptors|nmod|state receptors|compound|END_ENTITY	-LSB- Effect of placental transferrin receptors on iron nutritional state of normal full-term gravidas and their newborns -RSB- .
13868	0	iron	26,30	transferrin	46,57	iron	transferrin	MESH:D007501	7018	Chemical	Gene	START_ENTITY|acl|bound bound|nmod|END_ENTITY	Functional equivalence of iron bound to human transferrin at low pH or high pH. Human transferrin was labeled with 59Fe at one of its two metal-binding sites -LRB- designated A -RRB- at pH 6.0 .
1394993	0	iron	61,65	transferrin	80,91	iron	transferrin	MESH:D007501	7018	Chemical	Gene	saturation|compound|START_ENTITY saturation|nmod|END_ENTITY	Transferrin index : an alternative method for calculating the iron saturation of transferrin .
1400450	0	iron	31,35	transferrin	48,59	iron	transferrin	MESH:D007501	7018	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|END_ENTITY	Intermediate steps in cellular iron uptake from transferrin .
1400450	1	iron	96,100	transferrin	110,121	iron	transferrin	MESH:D007501	7018	Chemical	Gene	pool|nmod|START_ENTITY Detection|nmod|pool Detection|nmod|END_ENTITY	Detection of a cytoplasmic pool of iron , free of transferrin .
1445180	0	iron	123,127	transferrin	148,159	iron	transferrin	MESH:D007501	24825(Tax:10116)	Chemical	Gene	capacity|compound|START_ENTITY capacity|nmod|END_ENTITY	The relationship between homozygosity level and animal physiology : iron content of plasma and whole blood as well as total iron binding capacity by transferrin -LRB- TIBC -RRB- in rats of various inbreeding coefficient .
14551810	0	iron	26,30	transferrin	143,154	iron	transferrin	MESH:D007501	7018	Chemical	Gene	release|compound|START_ENTITY Kinetics|nmod|release Kinetics|dep|influence influence|nmod|END_ENTITY	Kinetics and mechanism of iron release from the bacterial ferric binding protein nFbp : exogenous anion influence and comparison with mammalian transferrin .
14643898	0	iron	116,120	transferrin	67,78	iron	transferrin	MESH:D007501	7018	Chemical	Gene	route|nmod|START_ENTITY END_ENTITY|nmod|route	Recycling , degradation and sensitivity to the synergistic anion of transferrin in the receptor-independent route of iron uptake by human hepatoma -LRB- HuH-7 -RRB- cells .
149016	0	iron	45,49	transferrin	16,27	iron	transferrin	MESH:D007501	7018	Chemical	Gene	changes|compound|START_ENTITY parallels|dobj|changes parallels|nsubj|END_ENTITY	Down syndrome - transferrin parallels plasma iron changes .
14998307	0	iron	99,103	transferrin	8,19	iron	transferrin	MESH:D007501	7018	Chemical	Gene	status|compound|START_ENTITY evaluation|nmod|status index|nmod|evaluation receptor|dep|index receptor|compound|END_ENTITY	Soluble transferrin receptor and soluble transferrin receptor-ferritin index for evaluation of the iron status in elderly patients .
15026283	0	iron	6,10	transferrin	22,33	iron	transferrin	MESH:D007501	7018	Chemical	Gene	iron|compound|START_ENTITY iron|dep|END_ENTITY	Serum iron , ferritin , transferrin , total iron binding capacity , hs-CRP , LDL cholesterol and magnesium in children ; new reference intervals using the Dade Dimension Clinical Chemistry System .
15044101	0	iron	44,48	transferrin	82,93	iron	transferrin	MESH:D007501	7018	Chemical	Gene	associated|nmod|START_ENTITY changes|acl|associated changes|dep|binding binding|nmod|END_ENTITY	Tertiary structural changes associated with iron binding and release in hen serum transferrin : a crystallographic and spectroscopic study .
15056890	0	iron	54,58	transferrin	10,21	iron	transferrin	MESH:D007501	24825(Tax:10116)	Chemical	Gene	bioavailability|nmod|START_ENTITY enhancing|dobj|bioavailability END_ENTITY|acl|enhancing	Effect of transferrin on enhancing bioavailability of iron .
15071397	0	iron	63,67	transferrin	68,79	iron	transferrin	MESH:D007501	24825(Tax:10116)	Chemical	Gene	complexes|compound|START_ENTITY complexes|compound|END_ENTITY	Assessment of inflammatory response and sequestration of blood iron transferrin complexes in a rat model of lung_injury resulting from exposure to low-frequency shock waves .
15083854	0	iron	87,91	transferrin	37,48	iron	transferrin	MESH:D007501	7018	Chemical	Gene	saturation|nmod|START_ENTITY END_ENTITY|dobj|saturation	The mortality risk of elevated serum transferrin saturation and consumption of dietary iron .
1510382	0	iron	80,84	transferrin	98,109	iron	transferrin	MESH:D007501	7018	Chemical	Gene	release|compound|START_ENTITY modulating|dobj|release modulating|nmod|END_ENTITY	Entry of iron into cells : a new role for the transferrin_receptor in modulating iron release from transferrin .
1510382	0	iron	9,13	transferrin	98,109	iron	transferrin	MESH:D007501	7018	Chemical	Gene	Entry|nmod|START_ENTITY Entry|dep|role role|nmod|transferrin_receptor transferrin_receptor|acl|modulating modulating|nmod|END_ENTITY	Entry of iron into cells : a new role for the transferrin_receptor in modulating iron release from transferrin .
1526029	0	iron	39,43	transferrin	59,70	iron	transferrin	MESH:D007501	7018	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of pH and citrate on binding of iron and gallium by transferrin in serum .
15292463	0	iron	28,32	transferrin	47,58	iron	transferrin	MESH:D007501	7018	Chemical	Gene	induced|nmod|START_ENTITY stress|acl|induced released|nsubj|stress released|nmod|END_ENTITY	Oxidative stress induced by iron released from transferrin in low pH peritoneal_dialysis solution .
15327995	0	iron	71,75	transferrin	111,122	iron	transferrin	MESH:D007501	7018	Chemical	Gene	release|compound|START_ENTITY value|nmod|release value|nmod|END_ENTITY	The low pKa value of iron-binding ligand Tyr188 and its implication in iron release and anion binding of human transferrin .
1536148	0	iron	53,57	transferrin	136,147	iron	transferrin	MESH:D007501	24825(Tax:10116)	Chemical	Gene	Uptake|nmod|START_ENTITY Uptake|dep|comparison comparison|nmod|END_ENTITY	Uptake of transferrin-bound and nontransferrin-bound iron by reticulocytes from the Belgrade laboratory_rat : comparison with Wistar rat transferrin and reticulocytes .
15377970	0	iron	72,76	transferrin	20,31	iron	transferrin	MESH:D007501	7018	Chemical	Gene	Response|acl|START_ENTITY Response|nmod|receptor receptor|compound|END_ENTITY	Response of soluble transferrin receptor and iron-related parameters to iron supplementation in elite , iron-depleted , nonanemic female athletes .
1550782	0	iron	48,52	transferrin	10,21	iron	transferrin	MESH:D007501	7018	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of transferrin , lactoferrin and chelated iron on human T-lymphocytes .
15517438	0	iron	38,42	transferrin	48,59	iron	transferrin	MESH:D007501	7018	Chemical	Gene	removal|nmod|START_ENTITY cooperativity|nmod|removal cooperativity|nmod|END_ENTITY	Large cooperativity in the removal of iron from transferrin at physiological temperature and chloride ion concentration .
15522410	0	iron	11,15	transferrin	21,32	iron	transferrin	MESH:D007501	7018	Chemical	Gene	Release|nmod|START_ENTITY Release|nmod|END_ENTITY	Release of iron from transferrin by phosphonocarboxylate and diphosphonate chelating agents .
15522424	0	iron	103,107	transferrin	55,66	iron	transferrin	MESH:D007501	7018	Chemical	Gene	mechanisms|compound|START_ENTITY implications|nmod|mechanisms END_ENTITY|dep|implications	Phosphate_ester hydrolysis is catalyzed by a bacterial transferrin : potential implications for in vivo iron transport mechanisms .
15642666	0	iron	48,52	transferrin	12,23	iron	transferrin	MESH:D007501	7018	Chemical	Gene	marker|nmod|START_ENTITY receptor|nmod|marker receptor|compound|END_ENTITY	The soluble transferrin receptor as a marker of iron homeostasis in normal subjects and in HFE-related hemochromatosis .
1567848	0	iron	58,62	transferrin	74,85	iron	transferrin	MESH:D007501	7018	Chemical	Gene	cooperativity|nmod|START_ENTITY switch|nmod|cooperativity release|nsubj|switch release|nmod|END_ENTITY	Receptor-induced switch in site-site cooperativity during iron release by transferrin .
15924420	0	iron	97,101	transferrin	53,64	iron	transferrin	MESH:D007501	7018	Chemical	Gene	release|compound|START_ENTITY mechanism|nmod|release insights|nmod|mechanism analysis|dep|insights analysis|nmod|ligands ligands|nmod|END_ENTITY	Mutational analysis of C-lobe ligands of human serum transferrin : insights into the mechanism of iron release .
15975770	0	iron	54,58	transferrin	30,41	iron	transferrin	MESH:D007501	7018	Chemical	Gene	properties|nsubj|START_ENTITY retains|xcomp|properties retains|nsubj|variant variant|nmod|END_ENTITY	The C2 variant of human serum transferrin retains the iron binding properties of the native protein .
15998048	0	iron	47,51	transferrin	77,88	iron	transferrin	MESH:D007501	7018	Chemical	Gene	pathways|nmod|START_ENTITY structure|nmod|pathways Effect|nmod|structure release|nsubj|Effect release|nmod|END_ENTITY	Effect of ligand structure on the pathways for iron release from human serum transferrin .
16111909	0	iron	78,82	transferrin	17,28	iron	transferrin	MESH:D007501	7018	Chemical	Gene	binding|compound|START_ENTITY associated|nmod|binding residues|acl|associated conservation|nmod|residues Evolution|dep|conservation Evolution|nmod|family family|compound|END_ENTITY	Evolution of the transferrin family : conservation of residues associated with iron and anion binding .
16258219	0	iron	164,168	transferrin	138,149	iron	transferrin	MESH:D007501	7018	Chemical	Gene	saturation|nmod|START_ENTITY saturation|compound|END_ENTITY	A Japanese family with ferroportin disease caused by a novel mutation of SLC40A1 gene : hyperferritinemia associated with a relatively low transferrin saturation of iron .
16271884	0	iron	48,52	transferrin	100,111	iron	transferrin	MESH:D007501	7018	Chemical	Gene	mechanism|nmod|START_ENTITY release|nsubj|mechanism release|nmod|END_ENTITY	The molecular mechanism for receptor-stimulated iron release from the plasma iron transport protein transferrin .
1629195	0	iron	18,22	transferrin	35,46	iron	transferrin	MESH:D007501	7018	Chemical	Gene	mechanisms|nmod|START_ENTITY uptake|nsubj|mechanisms uptake|nmod|END_ENTITY	Two mechanisms of iron uptake from transferrin by melanoma cells .
1657189	0	iron	33,37	transferrin	50,61	iron	transferrin	MESH:D007501	7018	Chemical	Gene	calcium|nmod|START_ENTITY Effects|nmod|calcium uptake|nsubj|Effects uptake|nmod|END_ENTITY	Effects of calcium on hepatocyte iron uptake from transferrin , iron-pyrophosphate and iron-ascorbate .
16595935	0	iron	95,99	transferrin	135,146	iron	transferrin	MESH:D007501	7018	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|cleavage cleavage|nmod|END_ENTITY	Proteases of a Bacillus_subtilis clinical isolate facilitate swarming and siderophore-mediated iron uptake via proteolytic cleavage of transferrin .
1675959	0	iron	23,27	transferrin	47,58	iron	transferrin	MESH:D007501	24825(Tax:10116)	Chemical	Gene	Specificity|nmod|START_ENTITY uptake|nsubj|Specificity uptake|nmod|END_ENTITY	Specificity of hepatic iron uptake from plasma transferrin in the rat .
16879716	0	iron	42,46	transferrin	97,108	iron	transferrin	MESH:D007501	24825(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY mediate|dobj|transport mediate|advcl|segregating segregating|nmod|END_ENTITY	Brain capillary endothelial cells mediate iron transport into the brain by segregating iron from transferrin without the involvement of divalent_metal_transporter_1 .
16879716	0	iron	87,91	transferrin	97,108	iron	transferrin	MESH:D007501	24825(Tax:10116)	Chemical	Gene	segregating|dobj|START_ENTITY segregating|nmod|END_ENTITY	Brain capillary endothelial cells mediate iron transport into the brain by segregating iron from transferrin without the involvement of divalent_metal_transporter_1 .
17206377	0	iron	47,51	transferrin	10,21	iron	transferrin	MESH:D007501	7018	Chemical	Gene	absorption|compound|START_ENTITY affect|dobj|absorption affect|nsubj|mutation mutation|compound|END_ENTITY	The G277S transferrin mutation does not affect iron absorption in iron deficient women .
17206377	0	iron	66,70	transferrin	10,21	iron	transferrin	MESH:D007501	7018	Chemical	Gene	women|compound|START_ENTITY affect|nmod|women affect|nsubj|mutation mutation|compound|END_ENTITY	The G277S transferrin mutation does not affect iron absorption in iron deficient women .
17229905	0	iron	35,39	transferrin	23,34	iron	transferrin	MESH:D007501	7018	Chemical	Gene	delivery|compound|START_ENTITY delivery|compound|END_ENTITY	Renal iron metabolism : transferrin iron delivery and the role of iron regulatory proteins .
17229905	0	iron	6,10	transferrin	23,34	iron	transferrin	MESH:D007501	7018	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|dep|delivery delivery|compound|END_ENTITY	Renal iron metabolism : transferrin iron delivery and the role of iron regulatory proteins .
17239470	0	iron	26,30	transferrin	14,25	iron	transferrin	MESH:D007501	7018	Chemical	Gene	release|compound|START_ENTITY release|amod|END_ENTITY	Inhibition of transferrin iron release increases in vitro drug carrier efficacy .
17313366	0	iron	116,120	transferrin	126,137	iron	transferrin	MESH:D007501	7018	Chemical	Gene	acquiring|dobj|START_ENTITY acquiring|nmod|END_ENTITY	High-affinity binding by the periplasmic iron-binding protein from Haemophilus_influenzae is required for acquiring iron from transferrin .
17327678	0	iron	49,53	transferrin	106,117	iron	transferrin	MESH:D007501	7018	Chemical	Gene	release|compound|START_ENTITY release|nmod|pair pair|nmod|N-lobe N-lobe|nmod|END_ENTITY	Structures of two mutants that probe the role in iron release of the dilysine pair in the N-lobe of human transferrin .
1737056	0	iron	10,14	transferrin	51,62	iron	transferrin	MESH:D007501	7018	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|control control|nmod|receptor receptor|compound|END_ENTITY	Effect of iron and retinoic_acid on the control of transferrin receptor and ferritin in the human promonocytic cell line U937 .
1747455	0	iron	36,40	transferrin	21,32	iron	transferrin	MESH:D007501	24825(Tax:10116)	Chemical	Gene	absorption|compound|START_ENTITY role|nmod|absorption role|nmod|END_ENTITY	The role of diferric transferrin in iron absorption and transferrin concentration in rat pancreatic juice and milk .
17511619	0	iron	41,45	transferrin	78,89	iron	transferrin	MESH:D007501	22041(Tax:10090)	Chemical	Gene	homoeostasis|compound|START_ENTITY effect|nmod|homoeostasis protein|nmod|effect homologous|nsubjpass|protein homologous|nmod|END_ENTITY	A novel murine protein with no effect on iron homoeostasis is homologous with transferrin and is the putative inhibitor of carbonic anhydrase .
17517884	0	iron	36,40	transferrin	51,62	iron	transferrin	MESH:D007501	7018	Chemical	Gene	uptake|compound|START_ENTITY induces|dobj|uptake induces|nmod|END_ENTITY	Sustained hydrogen_peroxide induces iron uptake by transferrin receptor-1 independent of the iron regulatory protein/iron-responsive element network .
17558864	0	iron	94,98	transferrin	34,45	iron	transferrin	MESH:D007501	7018	Chemical	Gene	stores|compound|START_ENTITY marrow|dobj|stores marrow|nsubj|utility utility|nmod|levels levels|compound|END_ENTITY	Clinical utility of serum soluble transferrin receptor levels and comparison with bone marrow iron stores as an index for iron-deficient erythropoiesis in a heterogeneous group of patients .
17630737	0	iron	44,48	transferrin	74,85	iron	transferrin	MESH:D007501	7018	Chemical	Gene	facilitating|dobj|START_ENTITY facilitating|nmod|END_ENTITY	Sulfate as a synergistic anion facilitating iron binding by the bacterial transferrin FbpA : the origins and effects of anion promiscuity .
17682669	0	iron	110,114	transferrin	44,55	iron	transferrin	MESH:D007501	7018	Chemical	Gene	-RSB-|compound|START_ENTITY method|nmod|-RSB- -LSB-|nmod|method -LSB-|dobj|comparison comparison|nmod|usefulness usefulness|nmod|determination determination|compound|END_ENTITY	-LSB- The comparison of diagnostic usefulness of transferrin determination by immunological and chemical method in iron deficiency anemia -RSB- .
17711300	0	iron	113,117	transferrin	91,102	iron	transferrin	MESH:D007501	7018	Chemical	Gene	release|compound|START_ENTITY END_ENTITY|nmod|release	Intrinsic fluorescence reports a global conformational change in the N-lobe of human serum transferrin following iron release .
1846518	0	iron	8,12	transferrin	26,37	iron	transferrin	MESH:D007501	7018	Chemical	Gene	release|compound|START_ENTITY release|nmod|END_ENTITY	Ferrous iron release from transferrin by human neutrophil-derived superoxide anion : effect of pH and iron saturation .
18986010	0	iron	58,62	transferrin	92,103	iron	transferrin	MESH:D007501	7018	Chemical	Gene	supplement|compound|START_ENTITY maintain|nsubj|supplement maintain|dobj|saturation saturation|compound|END_ENTITY	Anemia management in peritoneal dialysis patients : can an iron supplement maintain a normal transferrin saturation and hemoglobin level ?
19103311	0	iron	146,150	transferrin	42,53	iron	transferrin	MESH:D007501	7018	Chemical	Gene	released|nsubjpass|START_ENTITY induced|advcl|released pH|acl|induced assignment|nmod|pH allows|dobj|assignment allows|nsubj|Incorporation Incorporation|nmod|5-hydroxytryptophan 5-hydroxytryptophan|nmod|END_ENTITY	Incorporation of 5-hydroxytryptophan into transferrin and its receptor allows assignment of the pH induced changes in intrinsic fluorescence when iron is released .
1911786	0	iron	19,23	transferrin	37,48	iron	transferrin	MESH:D007501	7018	Chemical	Gene	release|compound|START_ENTITY release|nmod|END_ENTITY	Receptor-modulated iron release from transferrin : differential effects on N - and C-terminal sites .
1919507	0	iron	103,107	transferrin	113,124	iron	transferrin	MESH:D007501	22041(Tax:10090)	Chemical	Gene	uptake|nmod|START_ENTITY defective|nmod|uptake defective|nmod|END_ENTITY	Isolation and characterization of a mutant of Neisseria_gonorrhoeae that is defective in the uptake of iron from transferrin and haemoglobin and is avirulent in mouse subcutaneous chambers .
192509	0	iron	65,69	transferrin	70,81	iron	transferrin	MESH:D007501	7018	Chemical	Gene	START_ENTITY|dobj|levels levels|compound|END_ENTITY	Electron spin resonance measurements of blood caeruloplasmin and iron transferrin levels in patients with non-Hodgkin 's _ lymphoma .
19281173	0	iron	133,137	transferrin	87,98	iron	transferrin	MESH:D007501	7018	Chemical	Gene	released|nsubjpass|START_ENTITY increase|advcl|released increase|nsubj|contribution contribution|nmod|residues residues|nmod|C-lobe C-lobe|nmod|END_ENTITY	Inequivalent contribution of the five tryptophan residues in the C-lobe of human serum transferrin to the fluorescence increase when iron is released .
19820086	0	iron	77,81	transferrin	122,133	iron	transferrin	MESH:D007501	7018	Chemical	Gene	liberate|dobj|START_ENTITY liberate|nmod|END_ENTITY	Elucidation of the mechanism by which catecholamine stress hormones liberate iron from the innate immune defense proteins transferrin and lactoferrin .
1988034	0	iron	58,62	transferrin	68,79	iron	transferrin	MESH:D007501	7018	Chemical	Gene	release|nmod|START_ENTITY transferrin_receptor|nmod|release role|nmod|transferrin_receptor role|nmod|END_ENTITY	A new role for the transferrin_receptor in the release of iron from transferrin .
1991464	0	iron	58,62	transferrin	8,19	iron	transferrin	MESH:D007501	24825(Tax:10116)	Chemical	Gene	deliver|dobj|START_ENTITY END_ENTITY|parataxis|deliver	Fe3 + -LRB- 2 -RRB- - transferrin and Fe3 + -LRB- 2 -RRB- - asialotransferrin deliver iron to hepatocytes by an identical mechanism .
19917294	0	iron	23,27	transferrin	41,52	iron	transferrin	MESH:D007501	7018	Chemical	Gene	release|compound|START_ENTITY release|nmod|END_ENTITY	The unique kinetics of iron release from transferrin : the role of receptor , lobe-lobe interactions , and salt at endosomal pH. Transferrins are a family of bilobal iron-binding proteins that play the crucial role of binding ferric iron and keeping it in solution , thereby controlling the levels of this important metal .
19917294	0	iron	230,234	transferrin	41,52	iron	transferrin	MESH:D007501	7018	Chemical	Gene	role|nmod|START_ENTITY play|dobj|role family|ccomp|play family|nsubj|kinetics kinetics|nmod|release release|nmod|END_ENTITY	The unique kinetics of iron release from transferrin : the role of receptor , lobe-lobe interactions , and salt at endosomal pH. Transferrins are a family of bilobal iron-binding proteins that play the crucial role of binding ferric iron and keeping it in solution , thereby controlling the levels of this important metal .
20075442	0	iron	15,19	transferrin	36,47	iron	transferrin	MESH:D007501	7018	Chemical	Gene	status|compound|START_ENTITY status|nmod|level level|compound|END_ENTITY	-LSB- Evaluation of iron status by serum transferrin receptor level -RSB- .
20161024	0	iron	76,80	transferrin	10,21	iron	transferrin	MESH:D007501	7018	Chemical	Gene	transport|compound|START_ENTITY involved|nmod|transport interactions|acl|involved iron|dep|interactions iron|compound|END_ENTITY	Hijacking transferrin bound iron : protein-receptor interactions involved in iron transport in N. _ gonorrhoeae .
20188707	0	iron	85,89	transferrin	73,84	iron	transferrin	MESH:D007501	7018	Chemical	Gene	uptake|compound|START_ENTITY uptake|amod|END_ENTITY	Human MRCKalpha is regulated by cellular iron levels and interferes with transferrin iron uptake .
2022630	0	iron	157,161	transferrin	69,80	iron	transferrin	MESH:D007501	7018	Chemical	Gene	delivery|nmod|START_ENTITY understand|dobj|delivery order|acl|understand results|dep|order results|nmod|release release|nmod|END_ENTITY	Binding to cellular receptors results in increased iron release from transferrin at mildly acidic pH. In order to better understand the cellular delivery of iron from serum transferrin -LRB- Tf -RRB- , we compared iron release from receptor-bound and free Tf .
2022630	0	iron	203,207	transferrin	69,80	iron	transferrin	MESH:D007501	7018	Chemical	Gene	release|compound|START_ENTITY compared|dobj|release compared|ccomp|results results|nmod|release release|nmod|END_ENTITY	Binding to cellular receptors results in increased iron release from transferrin at mildly acidic pH. In order to better understand the cellular delivery of iron from serum transferrin -LRB- Tf -RRB- , we compared iron release from receptor-bound and free Tf .
2022630	0	iron	51,55	transferrin	69,80	iron	transferrin	MESH:D007501	7018	Chemical	Gene	release|compound|START_ENTITY release|nmod|END_ENTITY	Binding to cellular receptors results in increased iron release from transferrin at mildly acidic pH. In order to better understand the cellular delivery of iron from serum transferrin -LRB- Tf -RRB- , we compared iron release from receptor-bound and free Tf .
2037235	0	iron	15,19	transferrin	25,36	iron	transferrin	MESH:D007501	7018	Chemical	Gene	Acquisition|nmod|START_ENTITY Acquisition|nmod|END_ENTITY	Acquisition of iron from transferrin by Bordetella_pertussis .
20682781	0	iron	70,74	transferrin	80,91	iron	transferrin	MESH:D007501	7018	Chemical	Gene	assimilation|nmod|START_ENTITY promotes|dobj|assimilation promotes|nmod|END_ENTITY	ZRT/IRT-like _ protein_14 -LRB- ZIP14 -RRB- promotes the cellular assimilation of iron from transferrin .
20711621	0	iron	83,87	transferrin	121,132	iron	transferrin	MESH:D007501	7018	Chemical	Gene	release|compound|START_ENTITY accelerate|dobj|release accelerate|nmod|C-lobe C-lobe|nmod|END_ENTITY	Evidence that His349 acts as a pH-inducible switch to accelerate receptor-mediated iron release from the C-lobe of human transferrin .
2073459	0	iron	41,45	transferrin	51,62	iron	transferrin	MESH:D007501	7018	Chemical	Gene	distribution|nmod|START_ENTITY distribution|nmod|END_ENTITY	Uptake and intracellular distribution of iron from transferrin and chelators in erythroid cells .
20799798	0	iron	39,43	transferrin	80,91	iron	transferrin	MESH:D007501	7018	Chemical	Gene	START_ENTITY|nmod|endocytosis endocytosis|nmod|END_ENTITY	Real-time observation of the effect of iron on receptor-mediated endocytosis of transferrin conjugated with quantum dots .
21402762	0	iron	61,65	transferrin	87,98	iron	transferrin	MESH:D007501	7018	Chemical	Gene	liberated|compound|START_ENTITY capture|dobj|liberated capture|nmod|END_ENTITY	Staphylococcus_aureus transporters Hts , Sir , and Sst capture iron liberated from human transferrin by Staphyloferrin_A , Staphyloferrin_B , and catecholamine stress hormones , respectively , and contribute to virulence .
21450624	0	iron	94,98	transferrin	64,75	iron	transferrin	MESH:D007501	7018	Chemical	Gene	saturation|appos|START_ENTITY saturation|compound|END_ENTITY	Mortality from ischaemic_heart_disease : sex-specific effects of transferrin saturation , serum iron , and total iron binding capacity .
2151461	0	iron	34,38	transferrin	102,113	iron	transferrin	MESH:D007501	7018	Chemical	Gene	limitation|compound|START_ENTITY Haemophilus_somnus|nmod|limitation Response|nmod|Haemophilus_somnus Response|dep|expression expression|nmod|receptor receptor|compound|END_ENTITY	Response of Haemophilus_somnus to iron limitation : expression and identification of a bovine-specific transferrin receptor .
2156334	0	iron	48,52	transferrin	65,76	iron	transferrin	MESH:D007501	7018	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|END_ENTITY	Pyrophosphate-loaded hepatocytes show increased iron uptake from transferrin .
2165054	0	iron	12,16	transferrin	63,74	iron	transferrin	MESH:D007501	396996(Tax:9823)	Chemical	Gene	START_ENTITY|nmod|uteroferrin uteroferrin|acl|END_ENTITY	Transfer of iron from uteroferrin -LRB- purple_acid phosphatase -RRB- to transferrin related to acid phosphatase activity .
21699959	0	iron	12,16	transferrin	30,41	iron	transferrin	MESH:D007501	7018	Chemical	Gene	release|compound|START_ENTITY release|nmod|END_ENTITY	Kinetics of iron release from transferrin bound to the transferrin_receptor at endosomal pH. BACKGROUND : Human serum transferrin -LRB- hTF -RRB- is a bilobal glycoprotein that reversibly binds Fe -LRB- 3 + -RRB- and delivers it to cells by the process of receptor-mediated endocytosis .
21708099	0	iron	55,59	transferrin	79,90	iron	transferrin	MESH:D007501	7018	Chemical	Gene	release|compound|START_ENTITY rates|nmod|release anions|nmod|rates anions|nmod|END_ENTITY	Allosteric effects of sulfonate anions on the rates of iron release from serum transferrin .
21788477	0	iron	124,128	transferrin	25,36	iron	transferrin	MESH:D007501	7018	Chemical	Gene	Delivery|nmod|START_ENTITY potentiating|nmod|Delivery transferrin_receptor|acl|potentiating primes|dobj|transferrin_receptor primes|nsubj|the the|nmod|END_ENTITY	How the binding of human transferrin primes the transferrin_receptor potentiating iron release at endosomal pH. Delivery of iron to cells requires binding of two iron-containing human transferrin -LRB- hTF -RRB- molecules to the specific homodimeric transferrin_receptor -LRB- TFR -RRB- on the cell surface .
21788477	0	iron	82,86	transferrin	25,36	iron	transferrin	MESH:D007501	7018	Chemical	Gene	release|compound|START_ENTITY potentiating|dobj|release transferrin_receptor|acl|potentiating primes|dobj|transferrin_receptor primes|nsubj|the the|nmod|END_ENTITY	How the binding of human transferrin primes the transferrin_receptor potentiating iron release at endosomal pH. Delivery of iron to cells requires binding of two iron-containing human transferrin -LRB- hTF -RRB- molecules to the specific homodimeric transferrin_receptor -LRB- TFR -RRB- on the cell surface .
22085723	0	iron	14,18	transferrin	45,56	iron	transferrin	MESH:D007501	7018	Chemical	Gene	transport|compound|START_ENTITY Regulation|nmod|transport Regulation|nmod|END_ENTITY	Regulation of iron transport and the role of transferrin .
22099154	0	iron	143,147	transferrin	70,81	iron	transferrin	MESH:D007501	7018	Chemical	Gene	transports|dobj|START_ENTITY transports|nsubj|study study|nmod|complexes complexes|acl|formed formed|nmod|END_ENTITY	A QM/MM study of the complexes formed by aluminum and iron with serum transferrin at neutral and acidic pH. Serum transferrin -LRB- sTf -RRB- transports iron in serum and internalizes in cells via receptor mediated endocytosis .
22155077	0	iron	50,54	transferrin	23,34	iron	transferrin	MESH:D007501	7018	Chemical	Gene	agents|compound|START_ENTITY mobilization|nmod|agents mobilization|nmod|END_ENTITY	Iron mobilization from transferrin by therapeutic iron chelating agents .
22294463	0	iron	44,48	transferrin	29,40	iron	transferrin	MESH:D007501	7018	Chemical	Gene	biology|compound|START_ENTITY roles|nmod|biology roles|nmod|END_ENTITY	Known and potential roles of transferrin in iron biology .
22343719	0	iron	184,188	transferrin	24,35	iron	transferrin	MESH:D007501	7018	Chemical	Gene	acquires|dobj|START_ENTITY acquires|nsubj|basis basis|nmod|sequestration sequestration|compound|END_ENTITY	The structural basis of transferrin sequestration by transferrin-binding protein B. Neisseria_meningitidis , the causative agent of bacterial_meningitis , acquires the essential element iron from the host glycoprotein transferrin during infection through a surface transferrin receptor system composed of proteins TbpA and TbpB .
22345	0	iron	64,68	transferrin	74,85	iron	transferrin	MESH:D007501	7018	Chemical	Gene	release|nmod|START_ENTITY affecting|dobj|release affecting|nmod|END_ENTITY	Factors affecting the adenosine_triphosphate induced release of iron from transferrin .
22356162	0	iron	138,142	transferrin	160,171	iron	transferrin	MESH:D007501	7018	Chemical	Gene	release|nmod|START_ENTITY mechanism|nmod|release participating|nmod|mechanism participating|nmod|END_ENTITY	Structure-based mutagenesis reveals critical residues in the transferrin receptor participating in the mechanism of pH-induced release of iron from human serum transferrin .
22356162	0	iron	138,142	transferrin	61,72	iron	transferrin	MESH:D007501	7018	Chemical	Gene	release|nmod|START_ENTITY mechanism|nmod|release participating|nmod|mechanism receptor|acl|participating receptor|compound|END_ENTITY	Structure-based mutagenesis reveals critical residues in the transferrin receptor participating in the mechanism of pH-induced release of iron from human serum transferrin .
22364386	0	iron	54,58	transferrin	78,89	iron	transferrin	MESH:D007501	7018	Chemical	Gene	release|compound|START_ENTITY kinetics|nmod|release control|dobj|kinetics control|nmod|END_ENTITY	Protonation and anion binding control the kinetics of iron release from human transferrin .
22459167	0	iron	140,144	transferrin	46,57	iron	transferrin	MESH:D007501	7018	Chemical	Gene	species|compound|START_ENTITY bound|dobj|species non-transferrin|acl|bound complex|dep|non-transferrin Fe|dep|complex forming|dobj|Fe loading|advcl|forming loading|nmod|END_ENTITY	Phosphate inhibits in vitro Fe3 + loading into transferrin by forming a soluble Fe -LRB- III -RRB- - phosphate complex : a potential non-transferrin bound iron species .
2302189	0	iron	12,16	transferrin	42,53	iron	transferrin	MESH:D007501	280705(Tax:9913)	Chemical	Gene	Delivery|nmod|START_ENTITY Delivery|nmod|END_ENTITY	Delivery of iron to human cells by bovine transferrin .
23151869	0	iron	41,45	transferrin	66,77	iron	transferrin	MESH:D007501	7018	Chemical	Gene	saturation|compound|START_ENTITY saturation|nmod|END_ENTITY	Reference measurement procedures for the iron saturation in human transferrin based on IDMS and Raman scattering .
23541988	0	iron	114,118	transferrin	80,91	iron	transferrin	MESH:D007501	7018	Chemical	Gene	acquisition|compound|START_ENTITY receptor|nmod|acquisition receptor|compound|END_ENTITY	Secreted glyceraldehye-3-phosphate dehydrogenase is a multifunctional autocrine transferrin receptor for cellular iron acquisition .
23836816	0	iron	87,91	transferrin	75,86	iron	transferrin	MESH:D007501	7018	Chemical	Gene	utilization|compound|START_ENTITY utilization|compound|END_ENTITY	Conserved regions of gonococcal TbpB are critical for surface exposure and transferrin iron utilization .
23866	1	iron	148,152	transferrin	136,147	iron	transferrin	MESH:D007501	7018	Chemical	Gene	saturation|compound|START_ENTITY saturation|amod|END_ENTITY	Rabbit reticulocyte incorporation of iron from rabbit transferrin was independent of transferrin iron saturation but uptake from human transferrin was saturation dependent .
23866	1	iron	88,92	transferrin	136,147	iron	transferrin	MESH:D007501	7018	Chemical	Gene	incorporation|nmod|START_ENTITY independent|nsubj|incorporation independent|nmod|saturation saturation|amod|END_ENTITY	Rabbit reticulocyte incorporation of iron from rabbit transferrin was independent of transferrin iron saturation but uptake from human transferrin was saturation dependent .
2401848	0	iron	22,26	transferrin	60,71	iron	transferrin	MESH:D007501	7018	Chemical	Gene	status|compound|START_ENTITY Influence|nmod|status Influence|nmod|release release|nmod|receptor receptor|compound|END_ENTITY	Influence of cellular iron status on the release of soluble transferrin receptor from human promyelocytic leukemic HL60 cells .
24082455	0	iron	22,26	transferrin	4,15	iron	transferrin	MESH:D007501	7018	Chemical	Gene	bound|dobj|START_ENTITY END_ENTITY|acl|bound	Non transferrin bound iron : nature , manifestations and analytical approaches for estimation .
2415022	0	iron	11,15	transferrin	87,98	iron	transferrin	MESH:D007501	7018	Chemical	Gene	stain|compound|START_ENTITY stain|dep|application application|nmod|END_ENTITY	A specific iron stain for iron-binding proteins in polyacrylamide gels : application to transferrin and lactoferrin .
24264112	0	iron	11,15	transferrin	37,48	iron	transferrin	MESH:D007501	7018	Chemical	Gene	transferrin|compound|START_ENTITY Effects|nmod|transferrin END_ENTITY|nsubj|Effects	Effects of iron transferrin and zinc transferrin on ferritin synthesis by human lymphocytes .
2440461	0	iron	156,160	transferrin	21,32	iron	transferrin	MESH:D007501	24825(Tax:10116)	Chemical	Gene	involving|dobj|START_ENTITY mechanism|acl|involving effect|dep|mechanism effect|nmod|END_ENTITY	Biological effect of transferrin on mast cell mediator release during the passive cutaneous anaphylaxis reaction : a possible inhibition mechanism involving iron .
24567067	0	iron	61,65	transferrin	26,37	iron	transferrin	MESH:D007501	22041(Tax:10090)	Chemical	Gene	distribution|nmod|START_ENTITY Investigating|nmod|distribution Investigating|dobj|role role|nmod|END_ENTITY	Investigating the role of transferrin in the distribution of iron , manganese , copper , and zinc .
24953684	0	iron	140,144	transferrin	158,169	iron	transferrin	MESH:D007501	7018	Chemical	Gene	START_ENTITY|acl|delivered delivered|nmod|END_ENTITY	A new class of high-contrast Fe -LRB- II -RRB- selective fluorescent probes based on spirocyclized scaffolds for visualization of intracellular labile iron delivered by transferrin .
2542309	0	iron	28,32	transferrin	16,27	iron	transferrin	MESH:D007501	7018	Chemical	Gene	capacity|compound|START_ENTITY capacity|amod|END_ENTITY	Inactivation of transferrin iron binding capacity by the neutrophil myeloperoxidase system .
25425685	0	iron	118,122	transferrin	19,30	iron	transferrin	MESH:D007501	7018	Chemical	Gene	infusion|compound|START_ENTITY hepcidin|nmod|infusion hepcidin|nsubj|elevation elevation|nmod|saturation saturation|compound|END_ENTITY	Rapid elevation of transferrin saturation and serum hepcidin concentration in hemodialysis patients after intravenous iron infusion .
25435028	0	iron	22,26	transferrin	4,15	iron	transferrin	MESH:D007501	7018	Chemical	Gene	bound|dobj|START_ENTITY END_ENTITY|acl|bound	Non transferrin bound iron -LRB- NTBI -RRB- in acute_leukemias throughout conventional intensive chemotherapy : Kinetics of its appearance and potential predictive role in infectious complications .
25504720	1	iron	44,48	transferrin	83,94	iron	transferrin	MESH:D007501	7018	Chemical	Gene	piracy|compound|START_ENTITY Escape|nmod|piracy Escape|nmod|evolution evolution|nmod|END_ENTITY	Escape from bacterial iron piracy through rapid evolution of transferrin .
25944634	0	iron	46,50	transferrin	17,28	iron	transferrin	MESH:D007501	7018	Chemical	Gene	overload|compound|START_ENTITY reduce|dobj|overload END_ENTITY|xcomp|reduce	Increasing serum transferrin to reduce tissue iron overload due to ineffective erythropoiesis .
25944634	0	iron	46,50	transferrin	17,28	iron	transferrin	MESH:D007501	7018	Chemical	Gene	overload|compound|START_ENTITY reduce|dobj|overload END_ENTITY|xcomp|reduce	Increasing serum transferrin to reduce tissue iron overload due to ineffective erythropoiesis .
2642019	0	iron	47,51	transferrin	65,76	iron	transferrin	MESH:D007501	7018	Chemical	Gene	removal|compound|START_ENTITY kinetics|nmod|removal evaluation|nmod|kinetics evaluation|nmod|END_ENTITY	Further evaluation of the biphasic kinetics of iron removal from transferrin by 3,4-LICAMS .
26606902	0	iron	47,51	transferrin	70,81	iron	transferrin	MESH:D007501	7018	Chemical	Gene	sensing|nmod|START_ENTITY Luminescence|dobj|sensing Luminescence|nmod|dots dots|nmod|END_ENTITY	Luminescence turn-on/off sensing of biological iron by carbon dots in transferrin .
26646585	0	iron	14,18	transferrin	40,51	iron	transferrin	MESH:D007501	7018	Chemical	Gene	efficacy|compound|START_ENTITY efficacy|nmod|END_ENTITY	Assessing the iron delivery efficacy of transferrin in clinical samples by native electrospray ionization mass spectrometry .
2678449	0	iron	44,48	transferrin	4,15	iron	transferrin	MESH:D007501	7018	Chemical	Gene	metabolism|compound|START_ENTITY function|nmod|metabolism receptor|dep|function receptor|compound|END_ENTITY	The transferrin receptor : a key function in iron metabolism .
2741913	0	iron	19,23	transferrin	38,49	iron	transferrin	MESH:D007501	7018	Chemical	Gene	START_ENTITY|acl|released released|nmod|END_ENTITY	Hemolysates reduce iron released from transferrin .
2752211	0	iron	11,15	transferrin	28,39	iron	transferrin	MESH:D007501	24825(Tax:10116)	Chemical	Gene	overload|compound|START_ENTITY overload|nmod|END_ENTITY	Effects of iron overload on transferrin secretion by cultured fetal rat hepatocytes .
2852009	0	iron	37,41	transferrin	59,70	iron	transferrin	MESH:D007501	7018	Chemical	Gene	transfer|nmod|START_ENTITY transfer|nmod|END_ENTITY	The superoxide-dependent transfer of iron from ferritin to transferrin and lactoferrin .
2883038	0	iron	11,15	transferrin	55,66	iron	transferrin	MESH:D007501	7018	Chemical	Gene	Release|nmod|START_ENTITY step|nsubj|Release step|nmod|cycle cycle|compound|END_ENTITY	Release of iron from endosomes is an early step in the transferrin cycle .
2914136	0	iron	24,28	transferrin	42,53	iron	transferrin	MESH:D007501	7018	Chemical	Gene	release|compound|START_ENTITY mediate|dobj|release mediate|nmod|END_ENTITY	Human platelets mediate iron release from transferrin by adenine_nucleotide-dependent and - independent mechanisms .
2974803	0	iron	21,25	transferrin	45,56	iron	transferrin	MESH:D007501	7018	Chemical	Gene	removal|compound|START_ENTITY preference|nmod|removal preference|nmod|END_ENTITY	Domain preference in iron removal from human transferrin by the bacterial siderophores aerobactin and enterochelin .
2981898	0	iron	59,63	transferrin	24,35	iron	transferrin	MESH:D007501	7018	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|receptors receptors|compound|END_ENTITY	Regulation of K562 cell transferrin receptors by exogenous iron .
2996611	1	iron	91,95	transferrin	76,87	iron	transferrin	MESH:D007501	24825(Tax:10116)	Chemical	Gene	donor|compound|START_ENTITY END_ENTITY|nmod|donor	Diferric transferrin as iron donor and the effect of pyrophosphate .
3002966	0	iron	57,61	transferrin	14,25	iron	transferrin	MESH:D007501	7018	Chemical	Gene	donor|compound|START_ENTITY exclusively|nmod|donor function|advmod|exclusively function|nsubj|Evidence Evidence|dep|END_ENTITY	Evidence that transferrin may function exclusively as an iron donor in promoting lymphocyte proliferation .
3008845	0	iron	57,61	transferrin	81,92	iron	transferrin	MESH:D007501	7018	Chemical	Gene	domains|compound|START_ENTITY domains|nmod|END_ENTITY	The effects of salts and amino group modification on the iron binding domains of transferrin .
3021757	0	iron	11,15	transferrin	45,56	iron	transferrin	MESH:D007501	7018	Chemical	Gene	Absence|nmod|START_ENTITY transfer|nsubj|Absence transfer|nmod|END_ENTITY	Absence of iron transfer from uteroferrin to transferrin .
30489	0	iron	65,69	transferrin	77,88	iron	transferrin	MESH:D007501	24825(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY effect|nmod|release effect|nmod|END_ENTITY	The effect of acid pH and citrate on the release and exchange of iron on rat transferrin .
3099540	1	iron	55,59	transferrin	80,91	iron	transferrin	MESH:D007501	22041(Tax:10090)	Chemical	Gene	capacity|compound|START_ENTITY capacity|nmod|END_ENTITY	Role of unbound iron binding capacity of transferrin .
3121514	0	iron	23,27	transferrin	76,87	iron	transferrin	MESH:D007501	7018	Chemical	Gene	uptake|compound|START_ENTITY proteases|nmod|uptake Impact|nmod|proteases pyoverdin|nsubj|Impact pyoverdin|nmod|END_ENTITY	Impact of proteases on iron uptake of Pseudomonas_aeruginosa pyoverdin from transferrin and lactoferrin .
3132585	1	iron	244,248	transferrin	176,187	iron	transferrin	MESH:D007501	7018	Chemical	Gene	level|nmod|START_ENTITY regulated|nmod|level regulated|nsubjpass|Expression Expression|acl|detected detected|nmod|END_ENTITY	Expression of the meningococcal transferrin receptor , detected by assay with human transferrin conjugated to peroxidase , was regulated by the level of iron in the medium .
3134296	0	iron	142,146	transferrin	102,113	iron	transferrin	MESH:D007501	7018	Chemical	Gene	level|compound|START_ENTITY receptors|nmod|level receptors|compound|END_ENTITY	Mechanisms underlying T-lymphocyte activation : mitogen initiates and IL-2 amplifies the expression of transferrin receptors via intracellular iron level .
3141281	0	iron	115,119	transferrin	97,108	iron	transferrin	MESH:D007501	7018	Chemical	Gene	source|compound|START_ENTITY use|nmod|source use|dobj|END_ENTITY	Loss of transferrin_receptor activity in Neisseria_meningitidis correlates with inability to use transferrin as an iron source .
3182815	0	iron	74,78	transferrin	84,95	iron	transferrin	MESH:D007501	24825(Tax:10116)	Chemical	Gene	uptake|nmod|START_ENTITY mechanisms|nmod|uptake have|dobj|mechanisms have|nmod|END_ENTITY	Hepatocytes and reticulocytes have different mechanisms for the uptake of iron from transferrin .
3218790	0	iron	34,38	transferrin	42,53	iron	transferrin	MESH:D007501	7018	Chemical	Gene	START_ENTITY|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- The coefficient of saturation of iron in transferrin -RSB- .
3371425	0	iron	67,71	transferrin	14,25	iron	transferrin	MESH:D007501	7018	Chemical	Gene	supplying|dobj|START_ENTITY supports|advcl|supplying supports|nsubj|Evidence Evidence|dep|END_ENTITY	Evidence that transferrin supports cell proliferation by supplying iron for DNA synthesis .
3379048	0	iron	10,14	transferrin	20,31	iron	transferrin	MESH:D007501	24825(Tax:10116)	Chemical	Gene	Uptake|nmod|START_ENTITY Uptake|nmod|END_ENTITY	Uptake of iron from transferrin by isolated rat hepatocytes .
3383429	0	iron	23,27	transferrin	59,70	iron	transferrin	MESH:D007501	7018	Chemical	Gene	distribution|nmod|START_ENTITY distribution|nmod|sites sites|nmod|END_ENTITY	Random distribution of iron among the two binding sites of transferrin in patients with various hematologic_disorders .
3390148	0	iron	14,18	transferrin	55,66	iron	transferrin	MESH:D007501	7018	Chemical	Gene	uptake|compound|START_ENTITY subsequent|nsubj|uptake subsequent|nmod|endocytosis endocytosis|nmod|END_ENTITY	Haem inhibits iron uptake subsequent to endocytosis of transferrin in reticulocytes .
3390570	0	iron	19,23	transferrin	41,52	iron	transferrin	MESH:D007501	7018	Chemical	Gene	exchange|compound|START_ENTITY Characteristics|nmod|exchange Characteristics|nmod|END_ENTITY	Characteristics of iron exchange between transferrin and hepatocytes in culture .
3418418	0	iron	20,24	transferrin	66,77	iron	transferrin	MESH:D007501	7018	Chemical	Gene	absorption|compound|START_ENTITY Relationships|nmod|absorption Relationships|appos|saturation saturation|nmod|END_ENTITY	Relationships among iron absorption , percent saturation of plasma transferrin and serum ferritin concentration in humans .
3421902	0	iron	23,27	transferrin	33,44	iron	transferrin	MESH:D007501	22041(Tax:10090)	Chemical	Gene	Uptake|nmod|START_ENTITY Uptake|nmod|complexes complexes|compound|lactoferrin lactoferrin|compound|END_ENTITY	Uptake and handling of iron from transferrin , lactoferrin and immune complexes by a macrophage cell line .
3433005	0	iron	10,14	transferrin	20,31	iron	transferrin	MESH:D007501	24825(Tax:10116)	Chemical	Gene	Uptake|nmod|START_ENTITY Uptake|nmod|END_ENTITY	Uptake of iron from transferrin by isolated hepatocytes .
3530028	0	iron	14,18	transferrin	31,42	iron	transferrin	MESH:D007501	24825(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|END_ENTITY	Depression of iron uptake from transferrin by isolated hepatocytes in the presence of ethanol is a pH-dependent consequence of ethanol metabolism .
3610230	0	iron	106,110	transferrin	15,26	iron	transferrin	MESH:D007501	22041(Tax:10090)	Chemical	Gene	chelator|compound|START_ENTITY lymphocytes|nmod|chelator lymphocytes|nsubj|Replacement Replacement|nmod|END_ENTITY	Replacement of transferrin in serum-free cultures of mitogen-stimulated mouse lymphocytes by a lipophilic iron chelator .
3651826	0	iron	10,14	transferrin	104,115	iron	transferrin	MESH:D007501	7018	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|characterization characterization|nmod|receptor receptor|compound|END_ENTITY	Effect of iron and transferrin on pure oligodendrocytes in culture ; characterization of a high-affinity transferrin receptor at different ages .
3693344	0	iron	47,51	transferrin	15,26	iron	transferrin	MESH:D007501	7018	Chemical	Gene	reduction|nmod|START_ENTITY Involvement|nmod|reduction Involvement|nmod|END_ENTITY	Involvement of transferrin in the reduction of iron by the transplasma membrane electron transport system .
3715363	0	iron	10,14	transferrin	20,31	iron	transferrin	MESH:D007501	24825(Tax:10116)	Chemical	Gene	Uptake|nmod|START_ENTITY Uptake|nmod|END_ENTITY	Uptake of iron from transferrin by isolated hepatocytes .
3719094	0	iron	26,30	transferrin	52,63	iron	transferrin	MESH:D007501	7018	Chemical	Gene	distribution|nmod|START_ENTITY Nonrandom|dobj|distribution Nonrandom|advcl|circulating circulating|dobj|END_ENTITY	Nonrandom distribution of iron in circulating human transferrin .
3730295	0	iron	34,38	transferrin	11,22	iron	transferrin	MESH:D007501	7018	Chemical	Gene	absorption|compound|START_ENTITY enhance|dobj|absorption Failure|acl|enhance Failure|nmod|END_ENTITY	Failure of transferrin to enhance iron absorption in achlorhydric human subjects .
3749034	0	iron	49,53	transferrin	14,25	iron	transferrin	MESH:D007501	7018	Chemical	Gene	exchange|compound|START_ENTITY saturation|nmod|exchange saturation|nsubj|effect effect|nmod|END_ENTITY	The effect of transferrin saturation on internal iron exchange .
3759950	0	iron	45,49	transferrin	63,74	iron	transferrin	MESH:D007501	7018	Chemical	Gene	histidines|nmod|START_ENTITY influence|nmod|histidines release|nsubj|influence release|nmod|END_ENTITY	The influence of uncoordinated histidines on iron release from transferrin .
3779112	0	iron	25,29	transferrin	54,65	iron	transferrin	MESH:D007501	24825(Tax:10116)	Chemical	Gene	Independence|nmod|START_ENTITY absorption|nsubj|Independence absorption|nmod|content content|compound|END_ENTITY	Independence of in vitro iron absorption from mucosal transferrin content in rat jejunal and ileal segments .
3862428	0	iron	11,15	transferrin	51,62	iron	transferrin	MESH:D007501	7018	Chemical	Gene	START_ENTITY|nmod|sites sites|nmod|END_ENTITY	Release of iron from the two iron-binding sites of transferrin by cultured human cells : modulation by methylamine .
3872264	0	iron	79,83	transferrin	37,48	iron	transferrin	MESH:D007501	7018	Chemical	Gene	source|nmod|START_ENTITY use|nmod|source use|dobj|END_ENTITY	Haemophilus_influenzae can use human transferrin as a sole source for required iron .
3896889	0	iron	9,13	transferrin	26,37	iron	transferrin	MESH:D007501	7018	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|END_ENTITY	Cellular iron uptake from transferrin : is endocytosis the only mechanism ?
3942693	0	iron	84,88	transferrin	48,59	iron	transferrin	MESH:D007501	24825(Tax:10116)	Chemical	Gene	microenvironment|nmod|START_ENTITY microenvironment|compound|END_ENTITY	Fluorescence probe measurement of the pH of the transferrin microenvironment during iron uptake by rat bone marrow erythroid cells .
3942757	0	iron	13,17	transferrin	36,47	iron	transferrin	MESH:D007501	7018	Chemical	Gene	study|nmod|START_ENTITY mobilisation|nsubj|study mobilisation|nmod|END_ENTITY	The study of iron mobilisation from transferrin using alpha-ketohydroxy heteroaromatic chelators .
3943149	0	iron	23,27	transferrin	8,19	iron	transferrin	MESH:D007501	7018	Chemical	Gene	transport|compound|START_ENTITY Role|nmod|transport Role|nmod|END_ENTITY	Role of transferrin in iron transport between maternal and fetal circulations of a perfused lobule of human placenta .
3954965	0	iron	23,27	transferrin	35,46	iron	transferrin	MESH:D007501	7018	Chemical	Gene	START_ENTITY|nmod|iron iron|compound|END_ENTITY	Intracellular forms of iron during transferrin iron uptake by mitogen-stimulated human lymphocytes .
3955803	0	iron	52,56	transferrin	29,40	iron	transferrin	MESH:D007501	7018	Chemical	Gene	effect|nmod|START_ENTITY assay|dep|effect assay|nmod|END_ENTITY	Immunoturbidimetric assay of transferrin : effect of iron and need for serum blanks .
3970972	0	iron	23,27	transferrin	31,42	iron	transferrin	MESH:D007501	7018	Chemical	Gene	potential|nmod|START_ENTITY potential|nmod|END_ENTITY	Reduction potential of iron in transferrin .
3978231	0	iron	76,80	transferrin	64,75	iron	transferrin	MESH:D007501	7018	Chemical	Gene	utilization|compound|START_ENTITY utilization|compound|END_ENTITY	Regulation of heme synthesis in erythroid cells : hemin inhibits transferrin iron utilization but not protoporphyrin synthesis .
3978816	0	iron	46,50	transferrin	129,140	iron	transferrin	MESH:D007501	7018	Chemical	Gene	phenotype|nmod|START_ENTITY influence|nmod|phenotype Lack|nmod|influence determined|nsubj|Lack determined|dobj|END_ENTITY	Lack of influence of TfC genetic phenotype on iron , iron-binding capacity , percentage saturation , and immunologically determined transferrin in blood donor sera .
3989357	0	iron	50,54	transferrin	60,71	iron	transferrin	MESH:D007501	7018	Chemical	Gene	release|dobj|START_ENTITY release|nmod|END_ENTITY	Guinea_pig and human red cell hemolysates release iron from transferrin .
3991607	0	iron	58,62	transferrin	32,43	iron	transferrin	MESH:D007501	7018	Chemical	Gene	delivering|dobj|START_ENTITY Molecular|advcl|delivering Molecular|dobj|advantage advantage|nmod|END_ENTITY	Molecular advantage of diferric transferrin in delivering iron to reticulocytes : a comparative study .
4008170	0	iron	27,31	transferrin	51,62	iron	transferrin	MESH:D007501	22041(Tax:10090)	Chemical	Gene	transport|nmod|START_ENTITY END_ENTITY|nsubj|transport	Transmembrane transport of iron from extracellular transferrin by lymphoma cells .
4029396	0	iron	20,24	transferrin	38,49	iron	transferrin	MESH:D007501	7018	Chemical	Gene	removal|compound|START_ENTITY specificity|nmod|removal specificity|nmod|END_ENTITY	Site specificity of iron removal from transferrin by alpha-ketohydroxypyridine chelators .
4074838	0	iron	14,18	transferrin	50,61	iron	transferrin	MESH:D007501	7018	Chemical	Gene	effect|nmod|START_ENTITY binding|nsubj|effect binding|nmod|conformation conformation|nmod|END_ENTITY	The effect of iron binding on the conformation of transferrin .
4081644	0	iron	33,37	transferrin	12,23	iron	transferrin	MESH:D007501	7018	Chemical	Gene	absorption|compound|START_ENTITY regulate|dobj|absorption regulate|nsubj|END_ENTITY	Does plasma transferrin regulate iron absorption ?
42443	0	iron	28,32	transferrin	46,57	iron	transferrin	MESH:D007501	7018	Chemical	Gene	mechanism|nmod|START_ENTITY Studies|nmod|mechanism release|nsubj|Studies release|nmod|END_ENTITY	Studies on the mechanism of iron release from transferrin .
424657	0	iron	70,74	transferrin	29,40	iron	transferrin	MESH:D007501	24825(Tax:10116)	Chemical	Gene	absorption|compound|START_ENTITY Binding|nmod|absorption Binding|nmod|END_ENTITY	Binding of copper to mucosal transferrin and inhibition of intestinal iron absorption in rats .
444649	0	iron	16,20	transferrin	50,61	iron	transferrin	MESH:D007501	7018	Chemical	Gene	START_ENTITY|nmod|sites sites|nmod|END_ENTITY	Distribution of iron between the binding sites of transferrin in serum : methods and results in normal human subjects .
4563157	0	iron	27,31	transferrin	12,23	iron	transferrin	MESH:D007501	7018	Chemical	Gene	metabolism|compound|START_ENTITY role|nmod|metabolism role|nmod|END_ENTITY	The role of transferrin in iron metabolism .
465681	0	iron	35,39	transferrin	13,24	iron	transferrin	MESH:D007501	22041(Tax:10090)	Chemical	Gene	content|compound|START_ENTITY content|compound|END_ENTITY	-LSB- Hemoglobin , transferrin and total iron content in the blood serum in hyperoxia and during the protective action of urea -RSB- .
496901	0	iron	25,29	transferrin	63,74	iron	transferrin	MESH:D007501	24825(Tax:10116)	Chemical	Gene	mechanism|nmod|START_ENTITY uptake|nsubj|mechanism uptake|nmod|END_ENTITY	The mechanism of hepatic iron uptake from native and denatured transferrin and its subcellular metabolism in the liver cell .
504966	0	iron	6,10	transferrin	88,99	iron	transferrin	MESH:D007501	7018	Chemical	Gene	START_ENTITY|nmod|women women|nmod|saturation saturation|compound|END_ENTITY	Serum iron and transferrin saturation in women with special reference to women with low transferrin saturation .
594498	0	iron	62,66	transferrin	8,19	iron	transferrin	MESH:D007501	7018	Chemical	Gene	absorption|compound|START_ENTITY END_ENTITY|nmod|absorption	Mucosal transferrin and ferritin factors in the regulation of iron absorption .
6091257	0	iron	37,41	transferrin	11,22	iron	transferrin	MESH:D007501	7018	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of transferrin and uptake of iron by K-562 cells .
6092356	0	iron	10,14	transferrin	32,43	iron	transferrin	MESH:D007501	7018	Chemical	Gene	Effect|nmod|START_ENTITY chelators|nsubj|Effect chelators|nmod|receptor receptor|compound|END_ENTITY	Effect of iron chelators on the transferrin receptor in K562 cells .
6268404	0	iron	61,65	transferrin	71,82	iron	transferrin	MESH:D007501	24825(Tax:10116)	Chemical	Gene	Studies|nmod|START_ENTITY Studies|nmod|END_ENTITY	Studies on the mechanism of pyrophosphate-mediated uptake of iron from transferrin by isolated rat-liver mitochondria .
6318930	0	iron	58,62	transferrin	33,44	iron	transferrin	MESH:D007501	7018	Chemical	Gene	-RSB-|compound|START_ENTITY Modulation|nmod|-RSB- Modulation|nmod|expression expression|nmod|receptors receptors|compound|END_ENTITY	-LSB- Modulation of the expression of transferrin receptors by iron , hemin and protoporphyrin_IX -RSB- .
6326850	0	iron	10,14	transferrin	20,31	iron	transferrin	MESH:D007501	24825(Tax:10116)	Chemical	Gene	Uptake|nmod|START_ENTITY Uptake|nmod|END_ENTITY	Uptake of iron from transferrin by isolated hepatocytes .
6375346	0	iron	84,88	transferrin	56,67	iron	transferrin	MESH:D007501	7018	Chemical	Gene	saturation|nmod|START_ENTITY saturation|compound|END_ENTITY	Transferrin in disease II : defects in the regulation of transferrin saturation with iron contribute to susceptibility to infection .
6465862	7	iron	812,816	transferrin	874,885	iron	transferrin	MESH:D007501	7018	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|nsubjpass|transport	The data suggest that neuronal iron transport , much like that in other mammalian tissues , is transferrin mediated and that blockers of transferrin-iron release may be of value in conditions in which there is brain iron overload .
6572005	0	iron	60,64	transferrin	34,45	iron	transferrin	MESH:D007501	7018	Chemical	Gene	delivering|dobj|START_ENTITY Competitive|advcl|delivering Competitive|dobj|advantage advantage|nmod|END_ENTITY	Competitive advantage of diferric transferrin in delivering iron to reticulocytes .
6589596	0	iron	17,21	transferrin	45,56	iron	transferrin	MESH:D007501	7018	Chemical	Gene	Occupancy|nmod|START_ENTITY binding|nsubj|Occupancy binding|dobj|sites sites|nmod|END_ENTITY	Occupancy of the iron binding sites of human transferrin .
6693498	0	iron	13,17	transferrin	39,50	iron	transferrin	MESH:D007501	22041(Tax:10090)	Chemical	Gene	chelator|compound|START_ENTITY replace|nsubj|chelator replace|dobj|END_ENTITY	A lipophilic iron chelator can replace transferrin as a stimulator of cell proliferation and differentiation .
6743230	0	iron	18,22	transferrin	37,48	iron	transferrin	MESH:D007501	100009267(Tax:9986)	Chemical	Gene	saturation|compound|START_ENTITY effect|nmod|saturation effect|nmod|END_ENTITY	The effect of the iron saturation of transferrin on its binding and uptake by rabbit reticulocytes .
6769499	0	iron	16,20	transferrin	40,51	iron	transferrin	MESH:D007501	7018	Chemical	Gene	kinetics|nmod|START_ENTITY release|nsubj|kinetics release|nmod|END_ENTITY	The kinetics of iron release from human transferrin by EDTA .
677335	0	iron	36,40	transferrin	10,21	iron	transferrin	MESH:D007501	24825(Tax:10116)	Chemical	Gene	delivery|compound|START_ENTITY saturation|nmod|delivery saturation|nsubj|Effect Effect|nmod|END_ENTITY	Effect of transferrin saturation on iron delivery in rats .
6795121	0	iron	71,75	transferrin	85,96	iron	transferrin	MESH:D007501	22041(Tax:10090)	Chemical	Gene	Enhancement|nmod|START_ENTITY Enhancement|acl|bound bound|nmod|END_ENTITY	Enhancement of Neisseria_meningitidis_infection in mice by addition of iron bound to transferrin .
6800201	0	iron	10,14	transferrin	29,40	iron	transferrin	MESH:D007501	100009267(Tax:9986)	Chemical	Gene	saturation|compound|START_ENTITY saturation|nmod|END_ENTITY	Effect of iron saturation on transferrin uptake by reticulocytes .
6821698	0	iron	47,51	transferrin	20,31	iron	transferrin	MESH:D007501	24825(Tax:10116)	Chemical	Gene	absorption|compound|START_ENTITY significance|nmod|absorption significance|nmod|END_ENTITY	The significance of transferrin for intestinal iron absorption .
687622	0	iron	17,21	transferrin	22,33	iron	transferrin	MESH:D007501	24825(Tax:10116)	Chemical	Gene	sites|nmod|START_ENTITY END_ENTITY|nsubj|sites	Binding sites of iron transferrin on rat reticulocytes .
6885162	0	iron	118,122	transferrin	31,42	iron	transferrin	MESH:D007501	7018	Chemical	Gene	deprivation|compound|START_ENTITY alternative|nmod|deprivation mechanism|dep|alternative mechanism|nmod|END_ENTITY	Fungistatic mechanism of human transferrin for Rhizopus_oryzae and Trichophyton_mentagrophytes : alternative to simple iron deprivation .
6889967	0	iron	92,96	transferrin	62,73	iron	transferrin	MESH:D007501	22041(Tax:10090)	Chemical	Gene	enhancement|nmod|START_ENTITY enhancement|nmod|END_ENTITY	Tumor cell toxicity of stable gallium_nitrate : enhancement by transferrin and protection by iron .
6902969	0	iron	34,38	transferrin	19,30	iron	transferrin	MESH:D007501	24825(Tax:10116)	Chemical	Gene	absorption|compound|START_ENTITY role|nmod|absorption role|nmod|END_ENTITY	The role of plasma transferrin in iron absorption in the rat .
6941310	0	iron	22,26	transferrin	38,49	iron	transferrin	MESH:D007501	7018	Chemical	Gene	Uptake|nmod|START_ENTITY Uptake|nmod|END_ENTITY	Uptake and release of iron from human transferrin .
7115619	0	iron	45,49	transferrin	53,64	iron	transferrin	MESH:D007501	100009267(Tax:9986)	Chemical	Gene	absorbed|dobj|START_ENTITY absorbed|nmod|END_ENTITY	Molecular aspects of the binding of absorbed iron to transferrin .
7150235	0	iron	11,15	transferrin	43,54	iron	transferrin	MESH:D007501	100009267(Tax:9986)	Chemical	Gene	Removal|nmod|START_ENTITY END_ENTITY|nsubj|Removal	Removal of iron from diferric rabbit serum transferrin by rabbit reticulocytes .
7295641	0	iron	97,101	transferrin	40,51	iron	transferrin	MESH:D007501	7018	Chemical	Gene	terbium|nmod|START_ENTITY transfer|nmod|terbium Distance|dep|transfer Distance|nmod|sites sites|nmod|END_ENTITY	Distance between metal-binding sites in transferrin : energy transfer from bound terbium -LRB- III -RRB- to iron -LRB- III -RRB- or manganese -LRB- III -RRB- .
7305958	0	iron	55,59	transferrin	101,112	iron	transferrin	MESH:D007501	7018	Chemical	Gene	distribution|nmod|START_ENTITY influence|nmod|distribution influence|nmod|sites sites|nmod|END_ENTITY	The influence of pH on the equilibrium distribution of iron between the metal-binding sites of human transferrin .
7320714	0	iron	12,16	transferrin	36,47	iron	transferrin	MESH:D007501	7018	Chemical	Gene	compounds|nsubj|START_ENTITY compounds|nmod|preparations preparations|compound|END_ENTITY	Polynuclear iron compounds in human transferrin preparations .
7396826	0	iron	20,24	transferrin	60,71	iron	transferrin	MESH:D007501	7018	Chemical	Gene	distribution|nmod|START_ENTITY distribution|nmod|sites sites|nmod|serum serum|amod|END_ENTITY	The distribution of iron between the metal-binding sites of transferrin human serum .
7411140	0	iron	22,26	transferrin	85,96	iron	transferrin	MESH:D007501	24825(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY Relationships|nmod|metabolism Relationships|dep|exchange exchange|nmod|vanadium vanadium|nmod|END_ENTITY	Relationships between iron and vanadium metabolism : the exchange of vanadium between transferrin and ferritin .
7459282	2	iron	103,107	transferrin	85,96	iron	transferrin	MESH:D007501	7018	Chemical	Gene	bound|dobj|START_ENTITY bound|nsubj|Effects Effects|nmod|END_ENTITY	Effects of human transferrin bound iron and of serum on the stimulation of incorporation of 3H-thymidine into DNA .
7628272	6	iron	679,683	transferrin	642,653	iron	transferrin	MESH:D007501	24825(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY stained|nmod|administration stained|nsubj|END_ENTITY	In iron-deficient rats , transferrin was weakly stained after iron administration but was strongly stained after saline administration .
7649811	0	iron	66,70	transferrin	24,35	iron	transferrin	MESH:D007501	24825(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|nmod|receptors receptors|compound|END_ENTITY	Transient expression of transferrin receptors and localisation of iron in amoeboid microglia in postnatal rats .
7745107	0	iron	64,68	transferrin	11,22	iron	transferrin	MESH:D007501	7018	Chemical	Gene	deferiprone|compound|START_ENTITY saturation|nmod|deferiprone saturation|nsubj|Changes Changes|nmod|END_ENTITY	Changes in transferrin saturation after treatment with the oral iron chelator deferiprone in patients with iron_overload .
7766711	0	iron	28,32	transferrin	45,56	iron	transferrin	MESH:D007501	7018	Chemical	Gene	uptake|compound|START_ENTITY decreases|dobj|uptake decreases|nmod|END_ENTITY	Nitrogen_monoxide decreases iron uptake from transferrin but does not mobilise iron from prelabelled neoplastic cells .
7854209	0	iron	36,40	transferrin	50,61	iron	transferrin	MESH:D007501	7018	Chemical	Gene	utilization|nmod|START_ENTITY bound|nsubj|utilization bound|xcomp|END_ENTITY	Siderophore-mediated utilization of iron bound to transferrin by Vibrio_parahaemolyticus .
7863732	0	iron	121,125	transferrin	12,23	iron	transferrin	MESH:D007501	280705(Tax:9913)	Chemical	Gene	amounts|nmod|START_ENTITY fed|dobj|amounts calves|acl|fed serum|nmod|calves serum|dobj|concentration concentration|compound|END_ENTITY	Blood serum transferrin concentration in cattle in various physiological states , in veal calves fed different amounts of iron , and in cattle affected by infectious_and_non-infectious_diseases .
7883057	0	iron	91,95	transferrin	106,117	iron	transferrin	MESH:D007501	7018	Chemical	Gene	Perkinsus_marinus|nmod|START_ENTITY replication|nmod|Perkinsus_marinus Inhibition|nmod|replication chelators|nsubj|Inhibition chelators|dobj|END_ENTITY	Inhibition of in vitro replication of the oyster parasite Perkinsus_marinus by the natural iron chelators transferrin , lactoferrin , and desferrioxamine .
7894712	0	iron	69,73	transferrin	79,90	iron	transferrin	MESH:D007501	7018	Chemical	Gene	acquire|dobj|START_ENTITY acquire|nmod|END_ENTITY	Staphylococcus_aureus but not Staphylococcus_epidermidis can acquire iron from transferrin .
7929602	0	iron	28,32	transferrin	45,56	iron	transferrin	MESH:D007501	7018	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|END_ENTITY	Two saturable mechanisms of iron uptake from transferrin in human melanoma cells : the effect of transferrin concentration , chelators , and metabolic probes on transferrin and iron uptake .
7934822	1	iron	109,113	transferrin	137,148	iron	transferrin	MESH:D007501	7018	Chemical	Gene	acquisition|compound|START_ENTITY protein|nmod|acquisition functions|nmod|protein functions|nmod|END_ENTITY	functions as a periplasmic transport protein in iron acquisition from human transferrin .
8002525	0	iron	42,46	transferrin	15,26	iron	transferrin	MESH:D007501	100009267(Tax:9986)	Chemical	Gene	saturated|nmod|START_ENTITY saturated|nsubj|Interaction Interaction|nmod|END_ENTITY	Interaction of transferrin saturated with iron with lung surfactant in respiratory_failure .
8009060	0	iron	53,57	transferrin	89,100	iron	transferrin	MESH:D007501	7018	Chemical	Gene	START_ENTITY|appos|capacity capacity|nmod|END_ENTITY	-LSB- Effects of blood transfusion on the serum assays of iron , the total binding capacity of transferrin , vitamin_B12 and folates -RSB- .
8012557	0	iron	59,63	transferrin	31,42	iron	transferrin	MESH:D007501	7018	Chemical	Gene	Isolation|acl|START_ENTITY Isolation|nmod|forms forms|nmod|END_ENTITY	Isolation of the four forms of transferrin with respect to iron by high-performance liquid chromatography : comparison of three mammalian species .
8018702	0	iron	14,18	transferrin	43,54	iron	transferrin	MESH:D007501	7018	Chemical	Gene	Regulation|nmod|START_ENTITY uptake|nsubj|Regulation uptake|nmod|END_ENTITY	Regulation of iron uptake and transport by transferrin in Caco-2 cells , an intestinal cell line .
8039896	0	iron	15,19	transferrin	25,36	iron	transferrin	MESH:D007501	7018	Chemical	Gene	Acquisition|nmod|START_ENTITY Acquisition|nmod|END_ENTITY	Acquisition of iron from transferrin and lactoferrin by the protozoan Leishmania chagasi .
8055929	0	iron	17,21	transferrin	35,46	iron	transferrin	MESH:D007501	7018	Chemical	Gene	mechanism|nmod|START_ENTITY release|nsubj|mechanism release|nmod|END_ENTITY	The mechanism of iron release from transferrin .
808936	1	iron	103,107	transferrin	91,102	iron	transferrin	MESH:D007501	24825(Tax:10116)	Chemical	Gene	sites|compound|START_ENTITY sites|compound|END_ENTITY	In vivo differences between transferrin iron binding sites , and in vitro interbinding site iron exchange .
8116825	0	iron	101,105	transferrin	52,63	iron	transferrin	MESH:D007501	7018	Chemical	Gene	saturation|compound|START_ENTITY approach|dep|saturation approach|acl|quantitate quantitate|dobj|isoforms isoforms|compound|END_ENTITY	A new approach to quantitate carbohydrate-deficient transferrin isoforms in alcohol_abusers : partial iron saturation in isoelectric focusing/immunoblotting and laser densitometry .
8200334	0	iron	34,38	transferrin	44,55	iron	transferrin	MESH:D007501	24825(Tax:10116)	Chemical	Gene	process|nmod|START_ENTITY process|nmod|END_ENTITY	The process of cellular uptake of iron from transferrin .
8218271	0	iron	119,123	transferrin	107,118	iron	transferrin	MESH:D007501	7018	Chemical	Gene	release|compound|START_ENTITY release|amod|END_ENTITY	Structural evidence for a pH-sensitive dilysine trigger in the hen ovotransferrin N-lobe : implications for transferrin iron release .
8250840	0	iron	14,18	transferrin	95,106	iron	transferrin	MESH:D007501	7018	Chemical	Gene	metabolism|compound|START_ENTITY Modulation|nmod|metabolism Modulation|dep|changes changes|nmod|uptake uptake|compound|END_ENTITY	Modulation of iron metabolism in monocyte cell line U937 by inflammatory cytokines : changes in transferrin uptake , iron handling and ferritin mRNA .
830225	0	iron	10,14	transferrin	29,40	iron	transferrin	MESH:D007501	24825(Tax:10116)	Chemical	Gene	saturation|compound|START_ENTITY Effect|nmod|saturation Effect|nmod|END_ENTITY	Effect of iron saturation of transferrin on hepatic iron uptake : an in vitro study .
830225	0	iron	52,56	transferrin	29,40	iron	transferrin	MESH:D007501	24825(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY Effect|nmod|uptake Effect|nmod|END_ENTITY	Effect of iron saturation of transferrin on hepatic iron uptake : an in vitro study .
830782	2	iron	189,193	transferrin	159,170	iron	transferrin	MESH:D007501	24825(Tax:10116)	Chemical	Gene	absorption|compound|START_ENTITY uptake|nmod|absorption uptake|nmod|END_ENTITY	Selective uptake by erythroid precursors of radioiron from portal vein plasma transferrin during intestinal iron absorption .
8347616	0	iron	26,30	transferrin	44,55	iron	transferrin	MESH:D007501	7018	Chemical	Gene	release|compound|START_ENTITY release|nmod|END_ENTITY	The anion requirement for iron release from transferrin is preserved in the receptor-transferrin complex .
8358209	0	iron	22,26	transferrin	39,50	iron	transferrin	MESH:D007501	7018	Chemical	Gene	lead|nmod|START_ENTITY effect|nmod|lead uptake|nsubj|effect uptake|nmod|cells cells|amod|END_ENTITY	The effect of lead on iron uptake from transferrin in human erythroleukemia -LRB- K562 -RRB- cells .
8406790	0	iron	104,108	transferrin	41,52	iron	transferrin	MESH:D007501	7018	Chemical	Gene	START_ENTITY|nsubj|Expression Expression|nmod|receptor receptor|compound|END_ENTITY	Expression of the Haemophilus_influenzae transferrin receptor is repressible by hemin but not elemental iron alone .
8490018	0	iron	70,74	transferrin	49,60	iron	transferrin	MESH:D007501	7018	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|genes genes|compound|END_ENTITY	Posttranscriptional regulation of chimeric human transferrin genes by iron .
861377	0	iron	44,48	transferrin	8,19	iron	transferrin	MESH:D007501	24825(Tax:10116)	Chemical	Gene	distribution|compound|START_ENTITY determining|dobj|distribution END_ENTITY|acl|determining	Role of transferrin in determining internal iron distribution .
8665914	0	iron	16,20	transferrin	31,42	iron	transferrin	MESH:D007501	7018	Chemical	Gene	mechanism|nmod|START_ENTITY uptake|nsubj|mechanism uptake|nmod|END_ENTITY	A mechanism for iron uptake by transferrin .
8681959	0	iron	128,132	transferrin	70,81	iron	transferrin	MESH:D007501	7018	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|transferrin_receptor transferrin_receptor|nmod|rates rates|nmod|recycling recycling|compound|END_ENTITY	Effects of overexpression of the transferrin_receptor on the rates of transferrin recycling and uptake of non-transferrin-bound iron .
8704995	0	iron	58,62	transferrin	15,26	iron	transferrin	MESH:D007501	7018	Chemical	Gene	sources|nmod|START_ENTITY serum|nmod|sources serum|nsubj|Utilization Utilization|nmod|END_ENTITY	Utilization of transferrin and salmon serum as sources of iron by typical and atypical strains of Aeromonas_salmonicida .
8782865	0	iron	16,20	transferrin	68,79	iron	transferrin	MESH:D007501	24825(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|uptake uptake|nmod|receptors receptors|compound|END_ENTITY	Aluminum alters iron and manganese uptake and regulation of surface transferrin receptors in primary rat oligodendrocyte cultures .
8814203	0	iron	44,48	transferrin	88,99	iron	transferrin	MESH:D007501	7018	Chemical	Gene	acquire|dobj|START_ENTITY acquire|nmod|endocytosis endocytosis|nmod|END_ENTITY	Intestinal epithelia -LRB- Caco-2 -RRB- cells acquire iron through the basolateral endocytosis of transferrin .
8823311	0	iron	34,38	transferrin	57,68	iron	transferrin	MESH:D007501	7018	Chemical	Gene	intermediate|nmod|START_ENTITY transport|amod|intermediate transport|nmod|END_ENTITY	Mobilferrin is an intermediate in iron transport between transferrin and hemoglobin in K562 cells .
8889596	0	iron	37,41	transferrin	15,26	iron	transferrin	MESH:D007501	477071(Tax:9615)	Chemical	Gene	compounds|compound|START_ENTITY Replacement|nmod|compounds Replacement|nmod|END_ENTITY	Replacement of transferrin by simple iron compounds for MDCK cells grown and subcultured in serum-free medium .
8889603	0	iron	31,35	transferrin	48,59	iron	transferrin	MESH:D007501	7018	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|END_ENTITY	Intermediate steps in cellular iron uptake from transferrin .
889709	0	iron	12,16	transferrin	46,57	iron	transferrin	MESH:D007501	24825(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|regulation regulation|nmod|synthesis synthesis|compound|END_ENTITY	The role of iron in the regulation of hepatic transferrin synthesis .
8996422	0	iron	24,28	transferrin	50,61	iron	transferrin	MESH:D007501	7018	Chemical	Gene	overload|compound|START_ENTITY syndrome|nmod|overload syndrome|nmod|saturation saturation|compound|END_ENTITY	A new syndrome of liver iron overload with normal transferrin saturation .
911316	0	iron	37,41	transferrin	60,71	iron	transferrin	MESH:D007501	100009267(Tax:9986)	Chemical	Gene	vitro|nmod|START_ENTITY utilization|nmod|vitro bound|nsubj|utilization bound|nmod|END_ENTITY	Preferential utilization in vitro of iron bound to diferric transferrin by rabbit reticulocytes .
9208284	0	iron	15,19	transferrin	37,48	iron	transferrin	MESH:D007501	7018	Chemical	Gene	Competition|nmod|START_ENTITY Competition|nmod|END_ENTITY	Competition of iron and aluminum for transferrin : the molecular basis for aluminum deposition in iron-overloaded dialysis patients ?
9245618	0	iron	129,133	transferrin	117,128	iron	transferrin	MESH:D007501	7018	Chemical	Gene	acquisition|compound|START_ENTITY acquisition|amod|END_ENTITY	Sequence analysis of the structural tbpA gene : protein topology and variable regions within neisserial receptors for transferrin iron acquisition .
9341986	0	iron	88,92	transferrin	58,69	iron	transferrin	MESH:D007501	22041(Tax:10090)	Chemical	Gene	therapy|compound|START_ENTITY implications|nmod|therapy Alteration|dep|implications Alteration|nmod|distribution distribution|nmod|iron iron|nmod|END_ENTITY	Alteration in the organ distribution of iron by truncated transferrin : implications for iron chelation therapy .
951183	0	iron	151,155	transferrin	124,135	iron	transferrin	MESH:D007501	7018	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Comparison of the metabolism of 2 injectable iron preparations -LRB- sorbitol_iron and polymaltose iron -RRB- with the metabolism of transferrin and hemoglobin iron -RSB- .
951183	0	iron	46,50	transferrin	124,135	iron	transferrin	MESH:D007501	7018	Chemical	Gene	preparations|compound|START_ENTITY metabolism|nmod|preparations Comparison|nmod|metabolism Comparison|nmod|metabolism metabolism|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Comparison of the metabolism of 2 injectable iron preparations -LRB- sorbitol_iron and polymaltose iron -RRB- with the metabolism of transferrin and hemoglobin iron -RSB- .
951183	0	iron	95,99	transferrin	124,135	iron	transferrin	MESH:D007501	7018	Chemical	Gene	Comparison|appos|START_ENTITY Comparison|nmod|metabolism metabolism|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Comparison of the metabolism of 2 injectable iron preparations -LRB- sorbitol_iron and polymaltose iron -RRB- with the metabolism of transferrin and hemoglobin iron -RSB- .
9550556	0	iron	61,65	transferrin	6,17	iron	transferrin	MESH:D007501	7018	Chemical	Gene	overload|compound|START_ENTITY presence|nmod|overload decreased|nmod|presence decreased|nsubjpass|receptors receptors|compound|END_ENTITY	Serum transferrin receptors are decreased in the presence of iron overload .
9594081	0	iron	18,22	transferrin	56,67	iron	transferrin	MESH:D007501	7018	Chemical	Gene	status|compound|START_ENTITY Evaluation|nmod|status Evaluation|nmod|receptors receptors|amod|newborn newborn|nmod|END_ENTITY	Evaluation of the iron status of the newborn by soluble transferrin receptors in serum .
9609685	0	iron	127,131	transferrin	74,85	iron	transferrin	MESH:D007501	7018	Chemical	Gene	release|compound|START_ENTITY implicated|nmod|release change|acl|implicated reveal|dobj|change reveal|nsubj|structures structures|nmod|N-lobe N-lobe|nmod|END_ENTITY	Two high-resolution crystal structures of the recombinant N-lobe of human transferrin reveal a structural change implicated in iron release .
9673237	0	iron	44,48	transferrin	60,71	iron	transferrin	MESH:D007501	7018	Chemical	Gene	recognition|nmod|START_ENTITY recognition|nmod|END_ENTITY	Receptor-mediated recognition and uptake of iron from human transferrin by Staphylococcus_aureus and Staphylococcus_epidermidis .
9726030	0	iron	14,18	transferrin	181,192	iron	transferrin	MESH:D007501	7018	Chemical	Gene	metabolism|compound|START_ENTITY Regulation|nmod|metabolism Regulation|dep|gamma gamma|acl:relcl|induce induce|advcl|circulating circulating|dobj|receptors receptors|compound|END_ENTITY	Regulation of iron metabolism in the acute-phase response : interferon gamma and tumour necrosis factor alpha induce hypoferraemia , ferritin production and a decrease in circulating transferrin receptors in cancer patients .
974036	0	iron	29,33	transferrin	39,50	iron	transferrin	MESH:D007501	7018	Chemical	Gene	transfer|nmod|START_ENTITY mediated|dobj|transfer mediated|nmod|END_ENTITY	Chelate mediated transfer of iron from transferrin to desferrioxamine .
9741090	0	iron	33,37	transferrin	6,17	iron	transferrin	MESH:D007501	7018	Chemical	Gene	source|nmod|START_ENTITY END_ENTITY|nmod|source	Human transferrin as a source of iron for Streptococcus_intermedius .
9766237	0	iron	122,126	transferrin	56,67	iron	transferrin	MESH:D007501	7018	Chemical	Gene	uptake|nmod|START_ENTITY Cooperation|nmod|uptake Cooperation|nmod|components components|nmod|receptor receptor|compound|END_ENTITY	Cooperation between the components of the meningococcal transferrin receptor , TbpA and TbpB , in the uptake of transferrin iron by the 37-kDa ferric-binding protein -LRB- FbpA -RRB- .
985442	0	iron	66,70	transferrin	76,87	iron	transferrin	MESH:D007501	100009267(Tax:9986)	Chemical	Gene	remove|dobj|START_ENTITY remove|nmod|END_ENTITY	Failure of a cell-free system from rabbit reticulocytes to remove iron from transferrin .
9920962	0	iron	39,43	transferrin	5,16	iron	transferrin	MESH:D007501	7018	Chemical	Gene	metabolism|compound|START_ENTITY role|nmod|metabolism receptor|dep|role receptor|amod|END_ENTITY	-LSB- The transferrin receptor : its role in iron metabolism and its diagnosis utility -RSB- .
9989766	0	iron	17,21	transferrin	44,55	iron	transferrin	MESH:D007501	7018	Chemical	Gene	mechanism|compound|START_ENTITY mechanism|nmod|END_ENTITY	Activation of an iron uptake mechanism from transferrin in hepatocytes by small-molecular-weight iron complexes : implications for the pathogenesis of iron-overload disease .
9989766	0	iron	97,101	transferrin	44,55	iron	transferrin	MESH:D007501	7018	Chemical	Gene	complexes|compound|START_ENTITY hepatocytes|nmod|complexes END_ENTITY|nmod|hepatocytes	Activation of an iron uptake mechanism from transferrin in hepatocytes by small-molecular-weight iron complexes : implications for the pathogenesis of iron-overload disease .
2916654	1	iron	91,95	transferrin-receptor	44,64	iron	transferrin-receptor	MESH:D007501	7037	Chemical	Gene	synthesis|nmod|START_ENTITY synthesis|nsubj|regulation regulation|nmod|END_ENTITY	The regulation of transferrin-receptor and ferritin synthesis by iron in cultured fibroblastic-line cells .
10354382	0	iron	14,18	transferrin_receptor	62,82	iron	transferrin receptor	MESH:D007501	7037	Chemical	Gene	status|compound|START_ENTITY Evaluation|nmod|status Evaluation|acl|using using|dobj|END_ENTITY	Evaluation of iron status of Finnish blood donors using serum transferrin_receptor .
10468869	0	iron	59,63	transferrin_receptor	8,28	iron	transferrin receptor	MESH:D007501	7037	Chemical	Gene	loading|compound|START_ENTITY determinant|nmod|loading END_ENTITY|nmod|determinant	Soluble transferrin_receptor as a potential determinant of iron loading in congenital_anaemias due to ineffective erythropoiesis .
10518614	0	iron	72,76	transferrin_receptor	29,49	iron	transferrin receptor	MESH:D007501	7037	Chemical	Gene	chelation|compound|START_ENTITY transcription|nmod|chelation transcription|nsubj|activation activation|nmod|gene gene|compound|END_ENTITY	HIF-1-mediated activation of transferrin_receptor gene transcription by iron chelation .
10952228	0	iron	14,18	transferrin_receptor	63,83	iron	transferrin receptor	MESH:D007501	7037	Chemical	Gene	status|compound|START_ENTITY Assessment|nmod|status Assessment|nmod|assay assay|nmod|END_ENTITY	Assessment of iron status with a new fully automated assay for transferrin_receptor in human serum .
11078891	0	iron	85,89	transferrin_receptor	47,67	iron	transferrin receptor	MESH:D007501	7037	Chemical	Gene	homeostasis|compound|START_ENTITY critical|nmod|homeostasis critical|nsubj|Interactions Interactions|nmod|ectodomain ectodomain|nmod|HFE HFE|nmod|END_ENTITY	Interactions of the ectodomain of HFE with the transferrin_receptor are critical for iron homeostasis in cells .
11190796	0	iron	23,27	transferrin_receptor	120,140	iron	transferrin receptor	MESH:D007501	7037	Chemical	Gene	anemia|compound|START_ENTITY Discriminating|nmod|anemia vs|csubj|Discriminating vs|dobj|concentration concentration|compound|END_ENTITY	Discriminating between iron deficiency anemia and anemia_of_chronic_disease using traditional indices of iron status vs transferrin_receptor concentration .
11205697	0	iron	14,18	transferrin_receptor	120,140	iron	transferrin receptor	MESH:D007501	7037	Chemical	Gene	status|compound|START_ENTITY Evaluation|nmod|status Evaluation|acl|using using|dobj|assay assay|nmod|END_ENTITY	Evaluation of iron status in anemic patients with rheumatoid_arthritis using an automated immunoturbidimetric assay for transferrin_receptor .
1384627	0	iron	24,28	transferrin_receptor	42,62	iron	transferrin receptor	MESH:D007501	7037	Chemical	Gene	effect|nmod|START_ENTITY compounds|nsubj|effect compounds|nmod|expression expression|compound|END_ENTITY	The effect of different iron compounds on transferrin_receptor expression in term human cytotrophoblast cells .
1510382	0	iron	80,84	transferrin_receptor	45,65	iron	transferrin receptor	MESH:D007501	7037	Chemical	Gene	release|compound|START_ENTITY modulating|dobj|release END_ENTITY|acl|modulating	Entry of iron into cells : a new role for the transferrin_receptor in modulating iron release from transferrin .
1510382	0	iron	9,13	transferrin_receptor	45,65	iron	transferrin receptor	MESH:D007501	7037	Chemical	Gene	Entry|nmod|START_ENTITY Entry|dep|role role|nmod|END_ENTITY	Entry of iron into cells : a new role for the transferrin_receptor in modulating iron release from transferrin .
15163319	0	iron	31,35	transferrin_receptor	74,94	iron	transferrin receptor	MESH:D007501	7037	Chemical	Gene	have|dobj|START_ENTITY patients|acl:relcl|have reflect|nmod|patients reflect|nsubj|value value|compound|END_ENTITY	In patients who have stainable iron in the bone marrow an elevated plasma transferrin_receptor value may reflect functional iron_deficiency .
15672419	0	iron	123,127	transferrin_receptor	92,112	iron	transferrin receptor	MESH:D007501	7037	Chemical	Gene	uptake|compound|START_ENTITY uptake|amod|dependent dependent|amod|END_ENTITY	Sodium_ascorbate -LRB- vitamin_C -RRB- induces apoptosis in melanoma cells via the down-regulation of transferrin_receptor dependent iron uptake .
15755831	0	iron	68,72	transferrin_receptor	6,26	iron	transferrin receptor	MESH:D007501	7037	Chemical	Gene	status|compound|START_ENTITY indicators|nmod|status Serum|nmod|indicators Serum|dobj|END_ENTITY	Serum transferrin_receptor and zinc_protoporphyrin as indicators of iron status in African children .
16424878	0	iron	68,72	transferrin_receptor	37,57	iron	transferrin receptor	MESH:D007501	22042(Tax:10090)	Chemical	Gene	increases|dobj|START_ENTITY increases|nsubj|expression expression|nmod|END_ENTITY	Stratum-specific expression of human transferrin_receptor increases iron in mouse epidermis .
18541582	0	iron	121,125	transferrin_receptor	69,89	iron	transferrin receptor	MESH:D007501	7037	Chemical	Gene	stores|compound|START_ENTITY estimating|dobj|stores ferritin|advcl|estimating Comparison|acl|ferritin Comparison|nmod|concentration concentration|nmod|ratio ratio|nmod|END_ENTITY	Comparison of plasma ferritin concentration with the ratio of plasma transferrin_receptor to ferritin in estimating body iron stores : results of 4 intervention trials .
18635001	0	iron	19,23	transferrin_receptor	94,114	iron	transferrin receptor	MESH:D007501	7037	Chemical	Gene	ferristatin/NSC306711|compound|START_ENTITY promotes|nsubj|ferristatin/NSC306711 promotes|dobj|degradation degradation|nmod|END_ENTITY	The small-molecule iron transport inhibitor ferristatin/NSC306711 promotes degradation of the transferrin_receptor .
19743956	0	iron	79,83	transferrin_receptor	12,32	iron	transferrin receptor	MESH:D007501	7037	Chemical	Gene	status|compound|START_ENTITY test|nmod|status applicable|nmod|test F-Index|acl:relcl|applicable END_ENTITY|dep|F-Index	The soluble transferrin_receptor -LRB- TfR -RRB- - F-Index is not applicable as a test for iron status in patients with chronic_lymphocytic_leukemia .
1988034	0	iron	58,62	transferrin_receptor	19,39	iron	transferrin receptor	MESH:D007501	7037	Chemical	Gene	release|nmod|START_ENTITY END_ENTITY|nmod|release	A new role for the transferrin_receptor in the release of iron from transferrin .
20828813	0	iron	32,36	transferrin_receptor	57,77	iron	transferrin receptor	MESH:D007501	7037	Chemical	Gene	status|compound|START_ENTITY Impact|nmod|status Impact|nmod|expression expression|compound|END_ENTITY	Impact of maternal and neonatal iron status on placental transferrin_receptor expression in pregnant adolescents .
21699959	0	iron	12,16	transferrin_receptor	55,75	iron	transferrin receptor	MESH:D007501	7037	Chemical	Gene	release|compound|START_ENTITY release|nmod|transferrin transferrin|acl|bound bound|nmod|END_ENTITY	Kinetics of iron release from transferrin bound to the transferrin_receptor at endosomal pH. BACKGROUND : Human serum transferrin -LRB- hTF -RRB- is a bilobal glycoprotein that reversibly binds Fe -LRB- 3 + -RRB- and delivers it to cells by the process of receptor-mediated endocytosis .
21788477	0	iron	124,128	transferrin_receptor	48,68	iron	transferrin receptor	MESH:D007501	7037	Chemical	Gene	Delivery|nmod|START_ENTITY potentiating|nmod|Delivery END_ENTITY|acl|potentiating	How the binding of human transferrin primes the transferrin_receptor potentiating iron release at endosomal pH. Delivery of iron to cells requires binding of two iron-containing human transferrin -LRB- hTF -RRB- molecules to the specific homodimeric transferrin_receptor -LRB- TFR -RRB- on the cell surface .
21788477	0	iron	82,86	transferrin_receptor	48,68	iron	transferrin receptor	MESH:D007501	7037	Chemical	Gene	release|compound|START_ENTITY potentiating|dobj|release END_ENTITY|acl|potentiating	How the binding of human transferrin primes the transferrin_receptor potentiating iron release at endosomal pH. Delivery of iron to cells requires binding of two iron-containing human transferrin -LRB- hTF -RRB- molecules to the specific homodimeric transferrin_receptor -LRB- TFR -RRB- on the cell surface .
2386528	0	iron	110,114	transferrin_receptor	18,38	iron	transferrin receptor	MESH:D007501	22042(Tax:10090)	Chemical	Gene	levels|compound|START_ENTITY changes|nmod|levels mRNAs|nmod|changes mRNAs|nsubj|regulation regulation|nmod|peroxidase peroxidase|compound|END_ENTITY	The regulation of transferrin_receptor and glutathione peroxidase mRNAs synthesis by changes in intracellular iron levels .
2498873	0	iron	60,64	transferrin_receptor	90,110	iron	transferrin receptor	MESH:D007501	7037	Chemical	Gene	region|compound|START_ENTITY region|nmod|mRNA mRNA|compound|END_ENTITY	A cytosolic protein binds to structural elements within the iron regulatory region of the transferrin_receptor mRNA .
2985960	0	iron	35,39	transferrin_receptor	63,83	iron	transferrin receptor	MESH:D007501	7037	Chemical	Gene	alterations|nmod|START_ENTITY Effects|nmod|alterations Effects|nmod|biosynthesis biosynthesis|nmod|END_ENTITY	Effects of alterations in cellular iron on biosynthesis of the transferrin_receptor in K562 cells .
3162307	0	iron	50,54	transferrin_receptor	81,101	iron	transferrin receptor	MESH:D007501	7037	Chemical	Gene	START_ENTITY|nmod|gene gene|nmod|END_ENTITY	Two genetic loci participate in the regulation by iron of the gene for the human transferrin_receptor .
3608980	0	iron	92,96	transferrin_receptor	30,50	iron	transferrin receptor	MESH:D007501	7037	Chemical	Gene	required|nmod|START_ENTITY required|csubjpass|Noncoding Noncoding|dobj|sequences sequences|nmod|gene gene|compound|END_ENTITY	Noncoding 3 ' sequences of the transferrin_receptor gene are required for mRNA regulation by iron .
3785148	0	iron	30,34	transferrin_receptor	55,75	iron	transferrin receptor	MESH:D007501	7037	Chemical	Gene	START_ENTITY|nmod|gene gene|nmod|END_ENTITY	Transcriptional regulation by iron of the gene for the transferrin_receptor .
7788851	0	iron	61,65	transferrin_receptor	23,43	iron	transferrin receptor	MESH:D007501	7037	Chemical	Gene	domain|compound|START_ENTITY lacking|dobj|domain transfected|xcomp|lacking transfected|nmod|cDNA cDNA|compound|END_ENTITY	Cells transfected with transferrin_receptor cDNA lacking the iron regulatory domain become more sensitive to the DNA-damaging action of oxidative stress .
7943298	0	iron	76,80	transferrin_receptor	10,30	iron	transferrin receptor	MESH:D007501	7037	Chemical	Gene	demand|compound|START_ENTITY diabetic_pregnancies|nmod|demand END_ENTITY|nmod|diabetic_pregnancies	Placental transferrin_receptor in diabetic_pregnancies with increased fetal iron demand .
8092098	0	iron	14,18	transferrin_receptor	72,92	iron	transferrin receptor	MESH:D007501	7037	Chemical	Gene	status|compound|START_ENTITY Assessment|nmod|status Assessment|acl|childbearing childbearing|nmod|END_ENTITY	Assessment of iron status of Zairean women of childbearing age by serum transferrin_receptor .
8134170	0	iron	45,49	transferrin_receptor	6,26	iron	transferrin receptor	MESH:D007501	7037	Chemical	Gene	status|compound|START_ENTITY assessment|nmod|status END_ENTITY|nmod|assessment	Serum transferrin_receptor for assessment of iron status in healthy prepubertal and early pubertal boys .
8681959	0	iron	128,132	transferrin_receptor	33,53	iron	transferrin receptor	MESH:D007501	7037	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of overexpression of the transferrin_receptor on the rates of transferrin recycling and uptake of non-transferrin-bound iron .
9002972	0	iron	23,27	transferrin_receptor	116,136	iron	transferrin receptor	MESH:D007501	7037	Chemical	Gene	metabolism|compound|START_ENTITY Regulation|nmod|metabolism Regulation|dep|activation activation|nmod|expression expression|compound|END_ENTITY	Regulation of cellular iron metabolism by erythropoietin : activation of iron-regulatory protein and upregulation of transferrin_receptor expression in erythroid cells .
9127455	0	iron	97,101	transferrin_receptor	52,72	iron	transferrin receptor	MESH:D007501	7037	Chemical	Gene	concentrations|compound|START_ENTITY serum|dobj|concentrations relationships|acl|serum Components|dep|relationships Components|nmod|variation variation|nmod|END_ENTITY	Components of biological variation in serum soluble transferrin_receptor : relationships to serum iron , transferrin and ferritin concentrations , and immune and haematological variables .
9260868	0	iron	90,94	transferrin_receptor	14,34	iron	transferrin receptor	MESH:D007501	7037	Chemical	Gene	protein|compound|START_ENTITY activation|nmod|protein Modulation|nmod|activation Modulation|nmod|expression expression|compound|END_ENTITY	Modulation of transferrin_receptor expression by dexrazoxane -LRB- ICRF-187 -RRB- via activation of iron regulatory protein .
9551665	0	iron	10,14	transferrin_receptor	18,38	iron	transferrin receptor	MESH:D007501	7037	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of iron on transferrin_receptor expression by human placental syncytiotrophoblast cells .
9705350	0	iron	150,154	transferrin_receptor	97,117	iron	transferrin receptor	MESH:D007501	7037	Chemical	Gene	regulation|compound|START_ENTITY role|nmod|regulation implies|dobj|role implies|nsubj|Co-trafficking Co-trafficking|nmod|END_ENTITY	Co-trafficking of HFE , a nonclassical major histocompatibility complex class I protein , with the transferrin_receptor implies a role in intracellular iron regulation .
15528318	0	iron	66,70	transferrin_receptor_1	95,117	iron	transferrin receptor 1	MESH:D007501	7037	Chemical	Gene	levels|compound|START_ENTITY levels|nmod|END_ENTITY	The hereditary_hemochromatosis protein , HFE , lowers intracellular iron levels independently of transferrin_receptor_1 in TRVb cells .
16706826	0	iron	58,62	transferrin_receptor_2	8,30	iron	transferrin receptor 2	MESH:D007501	7036	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of transferrin_receptor_2 in hepatic accumulation of iron in patients with chronic hepatitis_C .
16893896	0	iron	126,130	transferrin_receptor_2	58,80	iron	transferrin receptor 2	MESH:D007501	7036	Chemical	Gene	sensing|compound|START_ENTITY mechanism|nmod|sensing suggests|dobj|mechanism suggests|nsubj|interaction interaction|nmod|END_ENTITY	Hereditary_hemochromatosis protein , HFE , interaction with transferrin_receptor_2 suggests a molecular mechanism for mammalian iron sensing .
17241880	0	iron	80,84	transferrin_receptor_2	35,57	iron	transferrin receptor 2	MESH:D007501	50765(Tax:10090)	Chemical	Gene	leads|xcomp|START_ENTITY leads|nsubj|disruption disruption|nmod|gene gene|amod|END_ENTITY	Targeted disruption of the hepatic transferrin_receptor_2 gene in mice leads to iron overload .
18353247	0	iron	91,95	transferrin_receptor_2	21,43	iron	transferrin receptor 2	MESH:D007501	100752766	Chemical	Gene	uptake|nmod|START_ENTITY increases|dobj|uptake increases|nsubj|association association|nmod|END_ENTITY	HFE association with transferrin_receptor_2 increases cellular uptake of transferrin-bound iron .
23333676	0	iron	115,119	transferrin_receptor_2	41,63	iron	transferrin receptor 2	MESH:D007501	50765(Tax:10090)	Chemical	Gene	disorders|compound|START_ENTITY changes|nmod|disorders case|nmod|changes support|dobj|case support|nsubj|perturbations perturbations|nmod|mouse mouse|amod|END_ENTITY	Brain transcriptome perturbations in the transferrin_receptor_2 mutant mouse support the case for brain changes in iron loading disorders , including effects relating to long-term depression and long-term potentiation .
24639653	0	iron	64,68	transferrin_receptor_2	20,42	iron	transferrin receptor 2	MESH:D007501	7036	Chemical	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	The role of hepatic transferrin_receptor_2 in the regulation of iron homeostasis in the body .
25403101	0	iron	75,79	transferrin_receptor_2	27,49	iron	transferrin receptor 2	MESH:D007501	50765(Tax:10090)	Chemical	Gene	restriction|compound|START_ENTITY erythropoiesis|nmod|restriction role|nmod|erythropoiesis role|nmod|END_ENTITY	A critical role for murine transferrin_receptor_2 in erythropoiesis during iron restriction .
26608187	0	iron	16,20	transferrin_receptor_2	78,100	iron	transferrin receptor 2	MESH:D007501	50765(Tax:10090)	Chemical	Gene	homeostasis|nsubj|START_ENTITY homeostasis|nmod|mice mice|nmod|deletion deletion|nmod|END_ENTITY	Normal systemic iron homeostasis in mice with macrophage-specific deletion of transferrin_receptor_2 .
2788773	0	iron	55,59	tumor_necrosis_factor	74,95	iron	tumor necrosis factor	MESH:D007501	21926(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|nmod|END_ENTITY	Induction of hypoferremia and modulation of macrophage iron metabolism by tumor_necrosis_factor .
3681344	0	iron	56,60	tumor_necrosis_factor	18,39	iron	tumor necrosis factor	MESH:D007501	7124	Chemical	Gene	depresses|dobj|START_ENTITY depresses|nsubj|END_ENTITY	Recombinant human tumor_necrosis_factor depresses serum iron in mice .
8388290	0	iron	11,15	tumor_necrosis_factor	54,75	iron	tumor necrosis factor	MESH:D007501	7124	Chemical	Gene	Exogenous|dobj|START_ENTITY Exogenous|nmod|factor factor|acl|determining determining|dobj|effect effect|nmod|END_ENTITY	-LSB- Exogenous iron as a factor determining the effect of tumor_necrosis_factor -LRB- TNF -RRB- on the Raji cell line -RSB- .
9215812	0	iron	125,129	tumor_necrosis_factor	46,67	iron	tumor necrosis factor	MESH:D007501	7124	Chemical	Gene	informed|nmod|START_ENTITY hypothesis|acl|informed END_ENTITY|dep|hypothesis	How does superoxide dismutase protect against tumor_necrosis_factor : a hypothesis informed by effect of superoxide on `` free '' iron .
22508410	0	iron	66,70	tumor_necrosis_factor-a	15,38	iron	tumor necrosis factor-a	MESH:D007501	7124	Chemical	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	High levels of tumor_necrosis_factor-a downregulate antimicrobial iron transport protein , Nramp1 , in chronic hemodialysis patients : a key factor for infection risk .
8917440	0	iron	95,99	tyrosine_hydroxylase	133,153	iron	tyrosine hydroxylase	MESH:D007501	7054	Chemical	Gene	environment|compound|START_ENTITY environment|nmod|END_ENTITY	M ssbauer , electron-paramagnetic-resonance and X-ray-absorption fine-structure studies of the iron environment in recombinant human tyrosine_hydroxylase .
11447267	0	iron	51,55	upstream_stimulatory_factor_2	68,97	iron	upstream stimulatory factor 2	MESH:D007501	22282(Tax:10090)	Chemical	Gene	overload|compound|START_ENTITY overload|nmod|END_ENTITY	Lack of hepcidin gene expression and severe tissue iron overload in upstream_stimulatory_factor_2 -LRB- USF2 -RRB- knockout mice .
6489695	0	iron	93,97	uroporphyrinogen_decarboxylase	42,72	iron	uroporphyrinogen decarboxylase	MESH:D007501	29421(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Dual mechanism of inhibition of rat liver uroporphyrinogen_decarboxylase activity by ferrous iron : its potential role in the genesis of porphyria cutanea_tarda .
11204699	0	iron	24,28	uteroferrin	82,93	iron	uteroferrin	MESH:D007501	397414(Tax:9823)	Chemical	Gene	infusion|nmod|START_ENTITY influence|nsubj|infusion influence|dobj|END_ENTITY	Intravenous infusion of iron and tetrahydrofolate does not influence intrauterine uteroferrin and secreted folate-binding protein content in swine .
1567935	0	iron	86,90	uteroferrin	110,121	iron	uteroferrin	MESH:D007501	397414(Tax:9823)	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Characterization and developmental expression of binding sites for the transplacental iron transport protein , uteroferrin , in fetal hematopoietic tissues .
3527760	0	iron	38,42	uteroferrin	8,19	iron	uteroferrin	MESH:D007501	397414(Tax:9823)	Chemical	Gene	transport|compound|START_ENTITY Role|nmod|transport Role|nmod|END_ENTITY	Role of uteroferrin in transplacental iron transport in the pig .
3700269	0	iron	33,37	uteroferrin	79,90	iron	uteroferrin	MESH:D007501	397414(Tax:9823)	Chemical	Gene	transport|compound|START_ENTITY uteroferrin|nmod|transport Role|nmod|uteroferrin Role|dep|relationship relationship|nmod|levels levels|compound|END_ENTITY	Role of uteroferrin in placental iron transport in swine : relationship between uteroferrin levels and iron deposition in the conceptus during gestation .
3700269	0	iron	33,37	uteroferrin	8,19	iron	uteroferrin	MESH:D007501	397414(Tax:9823)	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|nmod|transport	Role of uteroferrin in placental iron transport in swine : relationship between uteroferrin levels and iron deposition in the conceptus during gestation .
3885788	0	iron	20,24	uteroferrin	49,60	iron	uteroferrin	MESH:D007501	397414(Tax:9823)	Chemical	Gene	glycoprotein|compound|START_ENTITY Localization|nmod|glycoprotein Localization|appos|END_ENTITY	Localization of the iron transport glycoprotein , uteroferrin , in the porcine endometrium and placenta by using immunocolloidal gold .
6511697	0	iron	33,37	uteroferrin	8,19	iron	uteroferrin	MESH:D007501	397414(Tax:9823)	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|nmod|transport	Role of uteroferrin in placental iron transport : effect of maternal iron treatment on fetal iron and uteroferrin content and neonatal hemoglobin .
6511697	0	iron	68,72	uteroferrin	8,19	iron	uteroferrin	MESH:D007501	397414(Tax:9823)	Chemical	Gene	treatment|compound|START_ENTITY effect|nmod|treatment Role|dep|effect Role|nmod|END_ENTITY	Role of uteroferrin in placental iron transport : effect of maternal iron treatment on fetal iron and uteroferrin content and neonatal hemoglobin .
6511697	0	iron	92,96	uteroferrin	8,19	iron	uteroferrin	MESH:D007501	397414(Tax:9823)	Chemical	Gene	treatment|nmod|START_ENTITY effect|nmod|treatment Role|dep|effect Role|nmod|END_ENTITY	Role of uteroferrin in placental iron transport : effect of maternal iron treatment on fetal iron and uteroferrin content and neonatal hemoglobin .
7056739	0	iron	98,102	uteroferrin	45,56	iron	uteroferrin	MESH:D007501	397414(Tax:9823)	Chemical	Gene	metabolism|compound|START_ENTITY transfer|nmod|metabolism transfer|nmod|END_ENTITY	Iron transfer between the purple phosphatase uteroferrin and transferrin and its possible role in iron metabolism of the fetal pig .
8706019	0	iron	66,70	vascular_endothelial_growth_factor	17,51	iron	vascular endothelial growth factor	MESH:D007501	7422	Chemical	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	Up-regulation of vascular_endothelial_growth_factor production by iron chelators .
12388055	0	iron	55,59	xanthine_oxidoreductase	14,37	iron	xanthine oxidoreductase	MESH:D007501	7498	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of xanthine_oxidoreductase by intracellular iron .
18986986	0	iron-sulfur	3,14	Elp3	33,37	iron-sulfur	Elp3	CHEBI:30408	856019(Tax:4932)	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	An iron-sulfur cluster domain in Elp3 important for the structural integrity of elongator .
19454487	0	iron-sulfur	34,45	ISD11	6,11	iron-sulfur	ISD11	CHEBI:30408	57128	Chemical	Gene	assembly|amod|START_ENTITY essential|nmod|assembly essential|nsubj|END_ENTITY	Human ISD11 is essential for both iron-sulfur cluster assembly and maintenance of normal cellular iron homeostasis .
16341089	0	iron-sulfur	41,52	Isd11	18,23	iron-sulfur	Isd11	CHEBI:30408	57128	Chemical	Gene	synthesis|amod|START_ENTITY END_ENTITY|nmod|synthesis	Essential role of Isd11 in mitochondrial iron-sulfur cluster synthesis on Isu scaffold proteins .
18573874	0	iron-sulfur	44,55	Nbp35	6,11	iron-sulfur	Nbp35	CHEBI:30408	4682	Chemical	Gene	assembly|amod|START_ENTITY essential|nmod|assembly essential|nsubj|END_ENTITY	Human Nbp35 is essential for both cytosolic iron-sulfur protein assembly and iron homeostasis .
9666055	0	iron-sulfur	58,69	TYKY	70,74	iron-sulfur	TYKY	CHEBI:30408	4728	Chemical	Gene	subunit|amod|START_ENTITY subunit|compound|END_ENTITY	Genomic structure of the human NDUFS8 gene coding for the iron-sulfur TYKY subunit of the mitochondrial NADH : ubiquinone oxidoreductase .
24245804	0	iron-sulfur	14,25	Viperin	0,7	iron-sulfur	Viperin	CHEBI:30408	91543	Chemical	Gene	protein|amod|START_ENTITY protein|nsubj|END_ENTITY	Viperin is an iron-sulfur protein that inhibits genome synthesis of tick-borne_encephalitis_virus via radical SAM domain activity .
10942404	0	iron-sulfur	17,28	ferrochelatase	58,72	iron-sulfur	ferrochelatase	CHEBI:30408	2235	Chemical	Gene	ligands|amod|START_ENTITY ligands|nmod|END_ENTITY	Mutations in the iron-sulfur cluster ligands of the human ferrochelatase lead to erythropoietic_protoporphyria .
2103463	0	iron-sulfur	18,29	frx_B	44,49	iron-sulfur	frx B	CHEBI:30408	800458(Tax:4097)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A ferredoxin-type iron-sulfur protein gene , frx_B , is expressed in the chloroplasts of tobacco and spinach .
26504246	0	iron-sulfur	113,124	isp-1	93,98	iron-sulfur	isp-1	CHEBI:30408	177609(Tax:6239)	Chemical	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	Tether mutations that restore function and suppress pleiotropic phenotypes of the C. _ elegans isp-1 -LRB- qm150 -RRB- Rieske iron-sulfur protein .
20972894	0	iron_oxide	132,142	CCl4	67,71	iron oxide	CCl4	MESH:C000499	116637(Tax:10116)	Chemical	Gene	rats|nmod|START_ENTITY END_ENTITY|nmod|rats	MR Imaging of activated hepatic stellate cells in liver injured by CCl4 of rats with integrin-targeted ultrasmall superparamagnetic iron_oxide .
26616677	0	iron_oxide	21,31	CD163	50,55	iron oxide	CD163	MESH:C000499	93671(Tax:10090)	Chemical	Gene	nanoparticles|compound|START_ENTITY nanoparticles|nmod|END_ENTITY	Targeted gold-coated iron_oxide nanoparticles for CD163 detection in atherosclerosis by MRI .
20377770	0	iron_sucrose	25,37	erythropoietin	65,79	iron sucrose	erythropoietin	MESH:C008169	2056	Chemical	Gene	START_ENTITY|nmod|therapy therapy|compound|END_ENTITY	Comparison of parenteral iron_sucrose and ferric_chloride during erythropoietin therapy of haemodialysis patients .
18048325	0	iron_sulfur	57,68	THIC	86,90	iron sulfur	THIC	CHEBI:30408	817513(Tax:3702)	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Vitamin_B1 biosynthesis in plants requires the essential iron_sulfur cluster protein , THIC .
26236102	0	irsogladine	72,83	proton_pump	20,31	irsogladine	proton pump	MESH:C041836	479	Chemical	Gene	therapy|nmod|START_ENTITY therapy|compound|END_ENTITY	Effect of long-term proton_pump inhibitor therapy and healing effect of irsogladine on nonsteroidal anti-inflammatory drug-induced small-intestinal lesions in healthy volunteers .
1674359	0	isamoltane	39,49	5-HT1B	104,110	isamoltane	5-HT1B	MESH:C058392	25075(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|receptor receptor|amod|END_ENTITY	Biochemical and behavioural effects of isamoltane , a beta-adrenoceptor antagonist with affinity for the 5-HT1B receptor of rat brain .
10629878	0	isatin	12,18	MAO	34,37	isatin	MAO	MESH:D007510	29253(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	-LSB- Effects of isatin , an endogenous MAO inhibitor , on dopamine -LRB- DA -RRB- and acetylcholine -LRB- ACh -RRB- concentrations in rats -RSB- .
10774257	0	isatin	25,31	MAO	47,50	isatin	MAO	MESH:D007510	29253(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY -LSB-|dobj|role END_ENTITY|advcl|-LSB-	-LSB- Pharmacological role of isatin , an endogenous MAO inhibitor -RSB- .
1688707	0	isatin	24,30	MAO	46,49	isatin	MAO	MESH:D007510	29253(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|inhibitor inhibitor|compound|END_ENTITY	Serotonergic effects of isatin : an endogenous MAO inhibitor related to tribulin .
21441025	0	isatin	28,34	caspase-3	46,55	isatin	caspase-3	MESH:D007510	836	Chemical	Gene	analogs|compound|START_ENTITY analogs|nmod|inhibitors inhibitors|amod|END_ENTITY	Synthesis and evaluation of isatin analogs as caspase-3 inhibitors : introduction of a hydrophilic group increases potency in a whole cell assay .
22033021	0	isatin	13,19	caspase-3	31,40	isatin	caspase-3	MESH:D007510	12367(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Radiolabeled isatin binding to caspase-3 activation induced by anti-Fas antibody .
9072455	0	isatin	51,57	monoamine_oxidase	22,39	isatin	monoamine oxidase	MESH:D007510	29253(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY END_ENTITY|dobj|inhibitor	Role of an endogenous monoamine_oxidase inhibitor , isatin , in SHRSP brain .
9510091	0	isatin	17,23	monoamine_oxidase	39,56	isatin	monoamine oxidase	MESH:D007510	29253(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Determination of isatin , an endogenous monoamine_oxidase inhibitor , in urine and tissues of rats by HPLC .
16298874	0	isepamicin_sulfate	124,142	glucose-6-phosphate_dehydrogenase	43,76	isepamicin sulfate	glucose-6-phosphate dehydrogenase	MESH:C016927	2539	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of some antibiotics on activity of glucose-6-phosphate_dehydrogenase from human erythrocytes in vitro and effect of isepamicin_sulfate on activities of antioxidant enzymes in rat erythrocytes .
12937998	0	isoamyl_acetate	161,176	acetyltransferase	64,81	isoamyl acetate	acetyltransferase	MESH:C020377	853237(Tax:4932)	Chemical	Gene	production|nmod|START_ENTITY END_ENTITY|nmod|production	Heterologous expression of the Saccharomyces_cerevisiae alcohol acetyltransferase genes in Clostridium_acetobutylicum and Escherichia_coli for the production of isoamyl_acetate .
23707764	0	isoangustone_A	46,60	CDK2	0,4	isoangustone A	CDK2	MESH:C551631	1017	Chemical	Gene	targets|nmod|START_ENTITY targets|nsubj|END_ENTITY	CDK2 and mTOR are direct molecular targets of isoangustone_A in the suppression of human prostate_cancer cell growth .
2579540	0	isoantigen	16,26	ABH	0,3	isoantigen	ABH	MESH:D007519	8846	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	ABH blood group isoantigen expression in breast_carcinomas -- an immunohistochemical evaluation using monoclonal_antibodies .
16232608	0	isocitrate	25,35	IDH1	56,60	isocitrate	IDH1	MESH:C034219	855691(Tax:4932)	Chemical	Gene	dehydrogenase|amod|START_ENTITY disruption|amod|dehydrogenase disruption|appos|END_ENTITY	Effect of NAD + - dependent isocitrate dehydrogenase gene -LRB- IDH1 , IDH2 -RRB- disruption of sake yeast on organic acid composition in sake mash .
1644826	0	isocitrate	87,97	IDH1	54,58	isocitrate	IDH1	MESH:C034219	855691(Tax:4932)	Chemical	Gene	dehydrogenase|amod|START_ENTITY Cloning|dep|dehydrogenase Cloning|nmod|gene gene|acl|encoding encoding|dobj|subunit subunit|compound|END_ENTITY	Cloning and characterization of the gene encoding the IDH1 subunit of NAD -LRB- + -RRB- - dependent isocitrate dehydrogenase from Saccharomyces_cerevisiae .
21506885	0	isocitrate	47,57	IDH1	73,77	isocitrate	IDH1	MESH:C034219	15926(Tax:10090)	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	Protective role of cytosolic NADP -LRB- + -RRB- - dependent isocitrate dehydrogenase , IDH1 , in ischemic pre-conditioned kidney in mice .
22397365	0	isocitrate	25,35	IDH1	59,63	isocitrate	IDH1	MESH:C034219	3417	Chemical	Gene	alterations|nmod|START_ENTITY dehydrogenase|nsubj|alterations dehydrogenase|dobj|1 1|appos|END_ENTITY	Molecular alterations of isocitrate dehydrogenase 1 and 2 -LRB- IDH1 and IDH2 -RRB- metabolic genes and additional genetic mutations in newly diagnosed acute_myeloid_leukemia patients .
22821382	0	isocitrate	28,38	IDH1	157,161	isocitrate	IDH1	MESH:C034219	3417	Chemical	Gene	mutations|amod|START_ENTITY Analysis|dep|mutations Analysis|acl|carrying carrying|dobj|mutation mutation|compound|END_ENTITY	Analysis of NADP + - dependent isocitrate dehydrogenase-1 / 2 gene mutations in pediatric brain_tumors : report of a secondary anaplastic astrocytoma carrying the IDH1 mutation .
23232569	0	isocitrate	17,27	IDH1	48,52	isocitrate	IDH1	MESH:C034219	3417	Chemical	Gene	Mutations|nmod|START_ENTITY dehydrogenase|nsubj|Mutations dehydrogenase|dobj|genes genes|nummod|END_ENTITY	Mutations in the isocitrate dehydrogenase genes IDH1 and IDH2 in tumors .
25486927	0	isocitrate	30,40	IDH1	65,69	isocitrate	IDH2	MESH:C034219	3418	Chemical	Gene	mutations|nmod|START_ENTITY dehydrogenases|nsubj|mutations dehydrogenases|dobj|1 1|appos|END_ENTITY	Acquired somatic mutations of isocitrate dehydrogenases 1 and 2 -LRB- IDH1 and IDH2 -RRB- in preleukemic_disorders .
24211421	2	isocitrate	229,239	IDH3a	266,271	isocitrate	IDH3a	MESH:C034219	3419	Chemical	Gene	subunit|amod|START_ENTITY subunit|appos|END_ENTITY	In previous study , we found that isocitrate dehydrogenase 3a subunit -LRB- IDH3a -RRB- was upregulated in AFB1-induced carcinogenesis process .
10628872	0	isocitrate	146,156	Idp2p	172,177	isocitrate	Idp2p	MESH:C034219	850871(Tax:4932)	Chemical	Gene	dehydrogenase|compound|START_ENTITY dehydrogenase|appos|END_ENTITY	Cat8p , the activator of gluconeogenic genes in Saccharomyces_cerevisiae , regulates carbon source-dependent expression of NADP-dependent cytosolic isocitrate dehydrogenase -LRB- Idp2p -RRB- and lactate permease -LRB- Jen1p -RRB- .
10628872	0	isocitrate	146,156	Jen1p	201,206	isocitrate	Jen1p	MESH:C034219	853663(Tax:4932)	Chemical	Gene	dehydrogenase|compound|START_ENTITY dehydrogenase|appos|END_ENTITY	Cat8p , the activator of gluconeogenic genes in Saccharomyces_cerevisiae , regulates carbon source-dependent expression of NADP-dependent cytosolic isocitrate dehydrogenase -LRB- Idp2p -RRB- and lactate permease -LRB- Jen1p -RRB- .
25262187	0	isocitrate	45,55	milk	66,70	isocitrate	milk	MESH:C034219	100532204	Chemical	Gene	determination|nmod|START_ENTITY determination|nmod|END_ENTITY	Fluorometric determination of free and total isocitrate in bovine milk .
468739	0	isocoformycin	48,61	adenosine_deaminase	25,44	isocoformycin	adenosine deaminase	MESH:C025528	11486(Tax:10090)	Chemical	Gene	Studies|nmod|START_ENTITY Studies|nmod|END_ENTITY	Studies on inhibition of adenosine_deaminase by isocoformycin in vitro and in vivo .
6224636	0	isodesmosine	66,78	elastin	18,25	isodesmosine	elastin	MESH:D007524	2006	Chemical	Gene	estimation|nmod|START_ENTITY estimation|nmod|END_ENTITY	The estimation of elastin in fetal tissues by radioimmunoassay of isodesmosine .
17630204	0	isoeugenol	48,58	interleukin-2	15,28	isoeugenol	interleukin-2	MESH:C036643	16183(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Suppression of interleukin-2 gene expression by isoeugenol is mediated through down-regulation of NF-AT and NF-kappaB .
7617763	0	isoferulic_acid	38,53	interleukin-8	64,77	isoferulic acid	interleukin-8	MESH:C008180	20309(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Inhibitory effect of ferulic_acid and isoferulic_acid on murine interleukin-8 production in response to influenza_virus_infections in vitro and in vivo .
10704056	0	isoferulic_acid	38,53	macrophage_inflammatory_protein-2	75,108	isoferulic acid	macrophage inflammatory protein-2	MESH:C008180	20310(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	Inhibitory effect of ferulic_acid and isoferulic_acid on the production of macrophage_inflammatory_protein-2 in response to respiratory_syncytial_virus_infection in RAW264 .7 cells .
23931087	0	isoferulic_acid	33,48	tyrosinase	61,71	isoferulic acid	tyrosinase	MESH:C008180	7299	Chemical	Gene	Kinetics|nmod|START_ENTITY Kinetics|nmod|END_ENTITY	Kinetics of inhibitory effect of isoferulic_acid on mushroom tyrosinase .
11096068	0	isoflavenoid_genistein	10,32	p53	43,46	isoflavenoid genistein	p53	null	7157	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	The plant isoflavenoid_genistein activates p53 and Chk2 in an ATM-dependent manner .
20576422	0	isoflavone	8,18	insulin-like_growth_factor-I	29,57	isoflavone	insulin-like growth factor-I	CHEBI:18220	16000(Tax:10090)	Chemical	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	Dietary isoflavone increases insulin-like_growth_factor-I production , thereby promoting hair growth in mice .
21058191	0	isoflavone	89,99	prostate-specific_antigen	53,78	isoflavone	prostate-specific antigen	CHEBI:18220	354	Chemical	Gene	concentrations|compound|START_ENTITY concentrations|compound|END_ENTITY	Effects of a high dose , aglycone-rich soy extract on prostate-specific_antigen and serum isoflavone concentrations in men with localized_prostate_cancer .
17037735	0	isoflavone	16,26	resistin	49,57	isoflavone	resistin	CHEBI:18220	246250(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of soy isoflavone on gene expression of resistin in insulin-resistance rats -RSB- .
26573593	0	isoflavone_daidzein	79,98	BRF2	28,32	isoflavone daidzein	BRF2	null	66653(Tax:10090)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of proto-oncogene BRF2 in breast_cancer cells by the dietary soybean isoflavone_daidzein .
26166229	0	isoflavone_daidzein	8,27	Tfam	37,41	isoflavone daidzein	Tfam	null	21780(Tax:10090)	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|compound|END_ENTITY	Dietary isoflavone_daidzein promotes Tfam expression that increases mitochondrial biogenesis in C2C12 muscle cells .
19073877	0	isoflavone_genistein	4,24	E-cadherin	66,76	isoflavone genistein	E-cadherin	null	83502(Tax:10116)	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	Soy isoflavone_genistein upregulates epithelial adhesion molecule E-cadherin expression and attenuates beta-catenin signaling in mammary epithelial cells .
15097869	0	isoflavone_genistein	75,95	NF-kappaB	120,129	isoflavone genistein	NF-kappaB	null	4790	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Apoptosis-inducing effect of chemotherapeutic agents is potentiated by soy isoflavone_genistein , a natural inhibitor of NF-kappaB in BxPC-3 pancreatic_cancer cell line .
16629226	0	isoflavone_genistein	4,24	TNFalpha	49,57	isoflavone genistein	TNFalpha	null	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	The isoflavone_genistein inhibits LPS-stimulated TNFalpha , but not IL-6 expression in monocytes from hemodialysis patients and healthy subjects .
20137471	0	isoflavones	19,30	ATP_binding_cassette_A1	34,57	isoflavones	ATP binding cassette A1	MESH:D007529	313210(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|level level|amod|END_ENTITY	-LSB- The effect of soy isoflavones on ATP_binding_cassette_A1 expression level in rats without ovaries with atherosclerotic_plaque -RSB- .
21171385	0	isoflavones	16,27	Bax	49,52	isoflavones	Bax	MESH:D007529	24887(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of soy isoflavones on the expression of Bax mRNA and Ca -LRB- 2 + -RRB- - ATPase activity in ovaries of perimenopause rats -RSB- .
21712733	0	isoflavones	14,25	C-reactive_protein	41,59	isoflavones	C-reactive protein	MESH:D007529	1401	Chemical	Gene	START_ENTITY|acl|circulating circulating|dobj|END_ENTITY	Effect of soy isoflavones on circulating C-reactive_protein in postmenopausal women : meta-analysis of randomized controlled trials .
16870006	0	isoflavones	5,16	COX-2	66,71	isoflavones	COX-2	MESH:D007529	5743	Chemical	Gene	START_ENTITY|xcomp|suppress suppress|dobj|expression expression|compound|END_ENTITY	Soya isoflavones suppress phorbol_12-myristate_13-acetate-induced COX-2 expression in MCF-7 cells .
22981962	0	isoflavones	4,15	COX-2	139,144	isoflavones	COX-2	MESH:D007529	17709(Tax:10090)	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|12-O-tetradecanoylphorbol-13-acetate 12-O-tetradecanoylphorbol-13-acetate|dep|cutaneous cutaneous|acl|inflammation inflammation|nmod|modulation modulation|nmod|END_ENTITY	Soy isoflavones -LRB- daidzein _ genistein -RRB- inhibit 12-O-tetradecanoylphorbol-13-acetate -LRB- TPA -RRB- - induced cutaneous inflammation via modulation of COX-2 and NF-kB in Swiss albino mice .
18931042	0	isoflavones	82,93	G-protein_alpha_subunit	21,44	isoflavones	G-protein alpha subunit	MESH:D007529	20644752	Chemical	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	A Phytophthora_sojae G-protein_alpha_subunit is involved in chemotaxis to soybean isoflavones .
18424208	0	isoflavones	40,51	IGF-I_receptor	74,88	isoflavones	IGF-I receptor	MESH:D007529	3480	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Developmental changes and the impact of isoflavones on mRNA expression of IGF-I_receptor , EGF_receptor and related growth factors in porcine skeletal muscle cell cultures .
14723336	0	isoflavones	59,70	IL-1beta	14,22	isoflavones	IL-1beta	MESH:D007529	3553	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of IL-1beta and IL-6 in osteoblast-like cell by isoflavones extracted from Sophorae fructus .
26136059	0	isoflavones	38,49	PDE-5A	92,98	isoflavones	PDE-5A	MESH:D007529	171115(Tax:10116)	Chemical	Gene	derivatives|nmod|START_ENTITY derivatives|nmod|inhibitors inhibitors|compound|END_ENTITY	Semi-synthetic derivatives of natural isoflavones from Maclura pomifera as a novel class of PDE-5A inhibitors .
12730403	0	isoflavones	4,15	PPAR	73,77	isoflavones	PPAR	MESH:D007529	25747(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|pathways pathways|amod|END_ENTITY	Soy isoflavones exert antidiabetic and hypolipidemic effects through the PPAR pathways in obese Zucker rats and murine RAW 264.7 cells .
22254019	0	isoflavones	39,50	PPAR	85,89	isoflavones	PPAR	MESH:D007529	5465	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Potential health-modulating effects of isoflavones and metabolites via activation of PPAR and AhR .
16549448	0	isoflavones	24,35	PPARgamma	122,131	isoflavones	PPARgamma	MESH:D007529	5468	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activation activation|nmod|END_ENTITY	Differential effects of isoflavones , from Astragalus membranaceus and Pueraria thomsonii , on the activation of PPARalpha , PPARgamma , and adipocyte differentiation in vitro .
12426216	0	isoflavones	43,54	apolipoprotein_E	58,74	isoflavones	apolipoprotein E	MESH:D007529	11816(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	The atheroprotective effect of dietary soy isoflavones in apolipoprotein_E - / - mice requires the presence of estrogen_receptor-alpha .
15456640	0	isoflavones	21,32	cox-2	36,41	isoflavones	cox-2	MESH:D007529	17709(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effect of red clover isoflavones on cox-2 activity in murine and human monocyte/macrophage cells .
15195125	0	isoflavones	37,48	estrogen_receptor_beta	88,110	isoflavones	estrogen receptor beta	MESH:D007529	13983(Tax:10090)	Chemical	Gene	increase|nsubj|START_ENTITY increase|dobj|expression expression|amod|END_ENTITY	In the prostatic epithelium , dietary isoflavones from red clover significantly increase estrogen_receptor_beta and E-cadherin expression but decrease transforming growth factor beta1 .
17879747	0	isoflavones	42,53	interleukin-5	75,88	isoflavones	interleukin-5	MESH:D007529	3567	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	The role of alkoxy group on the A ring of isoflavones in the inhibition of interleukin-5 .
16364211	0	isoflavones	8,19	parvalbumin	26,37	isoflavones	parvalbumin	MESH:D007529	25269(Tax:10116)	Chemical	Gene	alter|nsubj|START_ENTITY alter|dobj|END_ENTITY	Soybean isoflavones alter parvalbumin in hippocampus of mid-aged normal female , ovariectomized female , and normal male rats .
17585019	0	isoflavones	113,124	sterol-12-alpha-hydroxylase	25,52	isoflavones	sterol-12-alpha-hydroxylase	MESH:D007529	13124(Tax:10090)	Chemical	Gene	upregulated|nmod|START_ENTITY upregulated|nsubjpass|END_ENTITY	Human and murine hepatic sterol-12-alpha-hydroxylase and other xenobiotic metabolism mRNA are upregulated by soy isoflavones .
15725649	0	isoflavones	70,81	sufu	115,119	isoflavones	sufu	MESH:D007529	51684	Chemical	Gene	content|nmod|START_ENTITY Effects|nmod|content Effects|nmod|END_ENTITY	Effects of fermentation temperature on the content and composition of isoflavones and beta-glucosidase activity in sufu .
12802736	0	isoflavonoid_sophoricoside	35,61	cyclooxygenase-2	84,100	isoflavonoid sophoricoside	cyclooxygenase-2	null	19225(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Anti-inflammatory action of legume isoflavonoid_sophoricoside through inhibition on cyclooxygenase-2 activity .
1632829	0	isoflavonoids	4,17	5-lipoxygenase	43,57	isoflavonoids	5-lipoxygenase	CHEBI:50753	240	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	New isoflavonoids as inhibitors of porcine 5-lipoxygenase .
10923779	0	isoflavonoids	29,42	lupin	23,28	isoflavonoids	lupin	CHEBI:50753	51251	Chemical	Gene	START_ENTITY|nsubj|analysis analysis|nmod|END_ENTITY	HPLC analysis of white lupin isoflavonoids .
8545857	0	isoflavonoids	57,70	sex_hormone-binding_globulin	14,42	isoflavonoids	sex hormone-binding globulin	CHEBI:50753	6462	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|production production|amod|END_ENTITY	Regulation of sex_hormone-binding_globulin production by isoflavonoids and patterns of isoflavonoid conjugation in HepG2 cell cultures .
18971302	0	isoflurane	28,38	HCN1	57,61	isoflurane	HCN1	MESH:D007530	15165(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|mice mice|compound|END_ENTITY	Subunit-specific effects of isoflurane on neuronal Ih in HCN1 knockout mice .
25072260	0	isoflurane	70,80	HIF-1a	50,56	isoflurane	HIF-1a	MESH:D007530	3091	Chemical	Gene	pathway|nmod|START_ENTITY pathway|compound|END_ENTITY	Prostate_cancer cell malignancy via modulation of HIF-1a pathway with isoflurane and propofol alone and in combination .
17522519	0	isoflurane	61,71	Heme_oxygenase-1	0,16	isoflurane	Heme oxygenase-1	MESH:D007530	24451(Tax:10116)	Chemical	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Heme_oxygenase-1 induction by the clinically used anesthetic isoflurane protects rat livers from ischemia/reperfusion injury .
19122672	0	isoflurane	58,68	Heme_oxygenase-1	0,16	isoflurane	Heme oxygenase-1	MESH:D007530	15368(Tax:10090)	Chemical	Gene	preconditioning|amod|START_ENTITY effect|nmod|preconditioning mediates|dobj|effect mediates|nsubj|END_ENTITY	Heme_oxygenase-1 mediates the anti-inflammatory effect of isoflurane preconditioning in LPS-stimulated macrophages .
20936719	0	isoflurane	12,22	ICAM-1	68,74	isoflurane	ICAM-1	MESH:D007530	25464(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of isoflurane , sevoflurane and desflurane on expression of ICAM-1 and VCAM-1 in LPS-induced rat lung microvascular endothelial cells -RSB- .
19332643	0	isoflurane	21,31	LFA-1	50,55	isoflurane	LFA-1	MESH:D007530	3683	Chemical	Gene	START_ENTITY|acl|bound bound|nmod|END_ENTITY	Crystal structure of isoflurane bound to integrin LFA-1 supports a unified mechanism of volatile anesthetic action in the immune and central nervous systems .
21876430	0	isoflurane	78,88	O-linked_b-N-acetylglucosamine	12,42	isoflurane	O-linked b-N-acetylglucosamine	MESH:D007530	8473	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Role Role|nmod|END_ENTITY	Role of the O-linked_b-N-acetylglucosamine in the cardioprotection induced by isoflurane .
7637187	0	isoflurane	15,25	TNF-alpha	46,55	isoflurane	TNF-alpha	MESH:D007530	7124	Chemical	Gene	START_ENTITY|nmod|secretion secretion|nmod|END_ENTITY	-LSB- The effect of isoflurane on the secretion of TNF-alpha and IL-1_beta from LPS-stimulated human peripheral blood monocytes -RSB- .
21519046	0	isoflurane	41,51	b-site_amyloid_precursor_protein-cleaving_enzyme	109,157	isoflurane	b-site amyloid precursor protein-cleaving enzyme	MESH:D007530	23621	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|levels levels|amod|END_ENTITY	The potential dual effects of anesthetic isoflurane on hypoxia-induced caspase-3 activation and increases in b-site_amyloid_precursor_protein-cleaving_enzyme levels .
21519046	0	isoflurane	41,51	caspase-3	71,80	isoflurane	caspase-3	MESH:D007530	836	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activation activation|amod|END_ENTITY	The potential dual effects of anesthetic isoflurane on hypoxia-induced caspase-3 activation and increases in b-site_amyloid_precursor_protein-cleaving_enzyme levels .
24523673	0	isoflurane	32,42	caspase-3	46,55	isoflurane	caspase-3	MESH:D007530	12367(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Different effects of anesthetic isoflurane on caspase-3 activation and cytosol cytochrome c levels between mice neural progenitor cells and neurons .
9893740	0	isoflurane	21,31	cytochrome_P450	50,65	isoflurane	cytochrome P450	MESH:D007530	100379244(Tax:10141)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Preventive effect of isoflurane on destruction of cytochrome_P450 during reductive dehalogenation of carbon_tetrachloride in guinea-pig liver microsomes .
12552200	0	isoflurane	15,25	dopamine_transporter	35,55	isoflurane	dopamine transporter	MESH:D007530	24898(Tax:10116)	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of isoflurane with the dopamine_transporter .
22072849	0	isoflurane	57,67	heme_oxygenase-1	27,43	isoflurane	heme oxygenase-1	MESH:D007530	24451(Tax:10116)	Chemical	Gene	prevents|nmod|START_ENTITY prevents|dobj|induction induction|amod|END_ENTITY	Hepatic_steatosis prevents heme_oxygenase-1 induction by isoflurane in the rat liver .
21471541	0	isoflurane	11,21	p65	30,33	isoflurane	p65	MESH:D007530	19697(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of isoflurane on Nfkb p65 , Gadd45a and Jnk1 expression in the vital organs of CBA/CA mice .
1897344	0	isoflurane	103,113	renin	7,12	isoflurane	renin	MESH:D007530	5972	Chemical	Gene	induced|nmod|START_ENTITY hypotension|acl|induced vasopressin|nmod|hypotension vasopressin|nsubj|END_ENTITY	Plasma renin , catecholamines , vasopressin and aldosterone during hypotension induced by labetalol with isoflurane .
15486189	0	isogranulatimide	61,77	Chk1	14,18	isogranulatimide	Chk1	MESH:C116644	1111	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of Chk1 by the G2 DNA damage checkpoint inhibitor isogranulatimide .
8283388	0	isoleucine	91,101	N-acetyltransferase	117,136	isoleucine	N-acetyltransferase	CHEBI:24898	116631(Tax:10116)	Chemical	Gene	stimulation|compound|START_ENTITY stimulation|nmod|activity activity|amod|END_ENTITY	Commonalities in vasoactive intestinal peptide and peptide N-terminal histidine_C-terminal isoleucine stimulation of N-acetyltransferase activity in the rat pineal .
393505	0	isoleucine	55,65	angiotensin_II	14,28	isoleucine	angiotensin II	CHEBI:24898	183	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|antagonist antagonist|amod|END_ENTITY	Effects of an angiotensin_II antagonist ; -LSB- sarcosine 1 , isoleucine 8 -RSB- angiotensin_II , on blood pressure , plasma renin activity and plasma aldosterone concentration in hypertensive and normotensive subjects taking oral contraceptives .
19048012	0	isoleucine	15,25	pericentriolar_material_1	51,76	isoleucine	pericentriolar material 1	CHEBI:24898	5108	Chemical	Gene	START_ENTITY|nmod|gene gene|amod|END_ENTITY	A threonine to isoleucine missense mutation in the pericentriolar_material_1 gene is strongly associated with schizophrenia .
2435588	0	isoleucine	83,93	prolactin	103,112	isoleucine	prolactin	CHEBI:24898	24683(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY secretion|compound|END_ENTITY	Vasoactive intestinal peptide and peptide with N-terminal histidine and C-terminal isoleucine increase prolactin secretion in cultured rat pituitary cells -LRB- GH4C1 -RRB- via a cAMP-dependent mechanism which involves transient elevation of intracellular Ca2 + .
22499515	0	isoliensinine	14,27	CYP3A	43,48	isoliensinine	CYP3A	MESH:C499779	170509(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	-LSB- Influence of isoliensinine on activity of CYP3A in rats -RSB- .
20026081	0	isoliquiritigenin	37,54	GSK3beta	14,22	isoliquiritigenin	GSK3beta	MESH:C040920	2932	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	AMPK-mediated GSK3beta inhibition by isoliquiritigenin contributes to protecting mitochondria against iron-catalyzed oxidative stress .
22186622	0	isoliquiritigenin	29,46	cystic_fibrosis_transmembrane_conductance_regulator	52,103	isoliquiritigenin	cystic fibrosis transmembrane conductance regulator	MESH:C040920	1080	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|compound|END_ENTITY	Novel action of the chalcone isoliquiritigenin as a cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- inhibitor : potential therapy for cholera and polycystic_kidney_disease .
15231412	5	isoliquiritigenin_chalcone	417,443	tyrosinase	462,472	isoliquiritigenin chalcone	tyrosinase	null	7299	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|compound|END_ENTITY	51 -LRB- 2003 -RRB- 1201 -RSB- , showing that isoliquiritigenin_chalcone -LRB- ILC -RRB- is a potent tyrosinase inhibitor , the present study aims to characterize the chalcone family as new tyrosinase inhibitors , and demonstrate their potential whitening potency .
1418078	0	isoniazid	65,74	Fibrinogen	0,10	isoniazid	Fibrinogen	MESH:D007538	2244	Chemical	Gene	administration|amod|START_ENTITY END_ENTITY|nmod|administration	Fibrinogen and antithrombin III blood levels fluctuations during isoniazid or isoniazid plus rifampicin administration .
21980963	0	isoniazid	61,70	NAT2	20,24	isoniazid	NAT2	MESH:D007538	10	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY variants|nmod|pharmacokinetics variants|nsubj|effect effect|nmod|END_ENTITY	Gene dose effect of NAT2 variants on the pharmacokinetics of isoniazid and acetylisoniazid in healthy Chinese subjects .
3098272	0	isoniazid	62,71	interferon-gamma	23,39	isoniazid	interferon-gamma	MESH:D007538	15978(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of recombinant interferon-gamma and chemotherapy with isoniazid and rifampicin on infections of mouse peritoneal macrophages with Listeria_monocytogenes and Mycobacterium microti in vitro .
1619288	0	isoniazid	69,78	interleukin-1	95,108	isoniazid	interleukin-1	MESH:D007538	3552	Chemical	Gene	START_ENTITY|nmod|secretion secretion|nmod|END_ENTITY	Studies on immunomodulatory properties of isoniazid : V. Influence of isoniazid on secretion of interleukin-1 .
1119830	0	isophane	23,31	insulin	32,39	isophane	insulin	null	3630	Chemical	Gene	therapy|amod|START_ENTITY therapy|compound|END_ENTITY	Chronic urticaria from isophane insulin therapy ; sensitivity associated with noninsulin components in commercial preparations .
1297601	0	isophane	41,49	insulin	96,103	isophane	insulin	null	3630	Chemical	Gene	insulin|compound|START_ENTITY insulin|nmod|END_ENTITY	-LSB- Action profile of a semisynthetic human isophane zinc insulin compared with customary isophane insulin -RSB- .
2692136	1	isophane	193,201	insulin	134,141	isophane	insulin	null	3630	Chemical	Gene	infusion|nmod|START_ENTITY infusion|compound|END_ENTITY	A comparison of continuous subcutaneous insulin infusion and multiple injection therapy with human isophane or human ultralente insulin at bedtime in insulin-dependent diabetics .
3304782	0	isophane	82,90	insulin	63,70	isophane	insulin	null	3630	Chemical	Gene	following|compound|START_ENTITY END_ENTITY|nmod|following	A comparison of the pharmacokinetics of human protamine_sodium insulin with human isophane insulin following subcutaneous injection in normal subjects .
21371502	0	isophthalic_acid	25,41	Tyrosinase	0,10	isophthalic acid	Tyrosinase	MESH:C059768	7299	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Tyrosinase inhibition by isophthalic_acid : kinetics and computational simulation .
1339347	1	isoprenaline	72,84	MP5	142,145	isoprenaline	MP5	MESH:D007545	381832(Tax:10090)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	mRNA regulation by isoprenaline and the nucleotide sequence of proline-rich_protein cDNA MP5 .
7867037	0	isoprenaline	78,90	Transforming_growth_factor_beta_1	0,33	isoprenaline	Transforming growth factor beta 1	MESH:D007545	7040	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Transforming_growth_factor_beta_1 and extracellular matrix gene expression in isoprenaline induced cardiac_hypertrophy : effects of inhibition of the renin-angiotensin system .
3446201	0	isoprenaline	10,22	elastin	33,40	isoprenaline	elastin	MESH:D007545	25043(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|content content|compound|END_ENTITY	Effect of isoprenaline on tissue elastin content and serum elastolytic activity in normal and hydrazinophthalazine-treated rats .
9640406	0	isoprenaline	10,22	leptin	33,39	isoprenaline	leptin	MESH:D007545	3952	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of isoprenaline on plasma leptin and lipolysis in humans .
12621527	0	isoprenaline	14,26	renin	45,50	isoprenaline	renin	MESH:D007545	24715(Tax:10116)	Chemical	Gene	infusion|amod|START_ENTITY effect|nmod|infusion effect|nmod|END_ENTITY	The effect of isoprenaline infusion on renal renin and angiotensinogen gene expression in the anaesthetised rat .
490364	0	isoprenaline	56,68	renin	72,77	isoprenaline	renin	MESH:D007545	24715(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	Influence of potassium , sodium , perfusion pressure , and isoprenaline on renin release induced by acute calcium deprivation .
872447	0	isoprenaline	14,26	renin	37,42	isoprenaline	renin	MESH:D007545	5972	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	The effect of isoprenaline on plasma renin activity in man : a dose-response curve .
16001217	0	isoprene	128,136	CO2	48,51	isoprene	CO2	MESH:C005059	717	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|concentration concentration|compound|END_ENTITY	The interacting effects of elevated atmospheric CO2 concentration , drought and leaf-to-air vapour pressure deficit on ecosystem isoprene fluxes .
19846523	0	isoprenoid	54,64	miR-122	98,105	isoprenoid	miR-122	CHEBI:24913	406906	Chemical	Gene	pathway|amod|START_ENTITY pathway|nmod|END_ENTITY	Modulation of hepatitis_C_virus RNA abundance and the isoprenoid biosynthesis pathway by microRNA miR-122 involves distinct mechanisms .
11943173	0	isoprenols	15,25	PPARgamma	56,65	isoprenols	PPARgamma	null	5468	Chemical	Gene	action|nmod|START_ENTITY action|nmod|END_ENTITY	Dual action of isoprenols from herbal medicines on both PPARgamma and PPARalpha in 3T3-L1 adipocytes and HepG2 hepatocytes .
7479910	0	isoprenyl	55,64	transferase	65,76	isoprenyl	transferase	null	44110(Tax:7227)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Activated Drosophila Ras1 is selectively suppressed by isoprenyl transferase inhibitors .
1722191	0	isoprinosine	10,22	IL-2	26,30	isoprinosine	IL-2	MESH:D007542	16183(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|production production|compound|END_ENTITY	Effect of isoprinosine on IL-2 , IFN-gamma and IL-4 production in vivo and in vitro .
2420734	0	isoprinosine	11,23	IL-2	56,60	isoprinosine	IL-2	MESH:D007542	3558	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|production production|appos|END_ENTITY	Effects of isoprinosine and NPT_15392 on interleukin-2 -LRB- IL-2 -RRB- production .
2412742	0	isoprinosine	11,23	interleukin-2	35,48	isoprinosine	interleukin-2	MESH:D007542	16183(Tax:10090)	Chemical	Gene	Ability|nmod|START_ENTITY Ability|acl|restore restore|dobj|production production|compound|END_ENTITY	Ability of isoprinosine to restore interleukin-2 production and T cell proliferation in autoimmune mice .
2420734	0	isoprinosine	11,23	interleukin-2	41,54	isoprinosine	interleukin-2	MESH:D007542	3558	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|production production|compound|END_ENTITY	Effects of isoprinosine and NPT_15392 on interleukin-2 -LRB- IL-2 -RRB- production .
2424829	0	isoprinosine	10,22	interleukin-2	41,54	isoprinosine	interleukin-2	MESH:D007542	3558	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of isoprinosine on sialylation of interleukin-2 .
2428762	0	isoprinosine	18,30	interleukin-2	34,47	isoprinosine	interleukin-2	MESH:D007542	16183(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	In vivo effect of isoprinosine on interleukin-2 production , lymphocyte mitogenesis and NK activity in normal and cyclophosphamide immunosuppressed mice .
2581997	0	isoprinosine	174,186	interleukin-2	32,45	isoprinosine	interleukin-2	MESH:D007542	3558	Chemical	Gene	treatment|amod|START_ENTITY restoration|nmod|treatment restoration|nmod|production production|compound|END_ENTITY	Partial restoration of impaired interleukin-2 production and Tac_antigen -LRB- putative interleukin-2 receptor -RRB- expression in patients with acquired_immune_deficiency_syndrome by isoprinosine treatment in vitro .
6207122	0	isoprinosine	10,22	interleukin_1_and_2	26,45	isoprinosine	interleukin 1 and 2	MESH:D007542	3552;3558	Chemical	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Effect of isoprinosine on interleukin_1_and_2 production and on suppressor cell activity in pokeweed mitogen stimulated cultures of B and T cells .
24720348	0	isopropyl	58,67	EP2	79,82	isopropyl	EP2	CHEBI:30353	5732	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Investigation of ocular events associated with taprenepag isopropyl , a topical EP2 agonist in development for treatment of glaucoma .
11878817	0	isopropyl_unoprostone	19,40	prostaglandin_transporter	101,126	isopropyl unoprostone	prostaglandin transporter	MESH:C072630	6578	Chemical	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|END_ENTITY	Comparison between isopropyl_unoprostone and latanoprost by prostaglandin_E -LRB- 2 -RRB- induction , affinity to prostaglandin_transporter , and intraocular metabolism .
20169448	0	isoprostane	17,28	adiponectin	84,95	isoprostane	adiponectin	MESH:D028421	9370	Chemical	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	Increased plasma isoprostane is associated with visceral fat , high molecular weight adiponectin , and metabolic complications in obese children .
16491351	0	isoprostanes	70,82	IL-6	47,51	isoprostanes	IL-6	MESH:D028421	3569	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nmod|END_ENTITY	Solar-simulated radiation induces secretion of IL-6 and production of isoprostanes in human skin in vivo .
11024044	0	isoprostanes	13,25	apolipoprotein_E	72,88	isoprostanes	apolipoprotein E	MESH:D028421	11816(Tax:10090)	Chemical	Gene	Reduction|nmod|START_ENTITY Reduction|nmod|END_ENTITY	Reduction of isoprostanes and regression of advanced atherosclerosis by apolipoprotein_E .
10973693	0	isoproterenol	10,23	CD11b	90,95	isoproterenol	CD11b	MESH:D007545	407124(Tax:9913)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	Effect of isoproterenol and dexamethasone on the lipopolysaccharide induced expression of CD11b on bovine neutrophils .
12676735	0	isoproterenol	49,62	ERK	27,30	isoproterenol	ERK	MESH:D007545	24338(Tax:10116)	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Mechanism of activation of ERK and H-K-ATPase by isoproterenol in rat cortical collecting duct .
2233752	0	isoproterenol	69,82	Lipoprotein_lipase	0,18	isoproterenol	Lipoprotein lipase	MESH:D007545	24539(Tax:10116)	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	Lipoprotein_lipase gene expression in rat adipocytes is regulated by isoproterenol and insulin through different mechanisms .
23019951	0	isoproterenol	68,81	Smad2	49,54	isoproterenol	Smad2	MESH:D007545	29357(Tax:10116)	Chemical	Gene	rats|amod|START_ENTITY END_ENTITY|nmod|rats	-LSB- Effects of Sini decoction on the expressions of Smad2 and Smad7 in isoproterenol induced myocardial_fibrosis rats -RSB- .
16180338	0	isoproterenol	72,85	TNFalpha	112,120	isoproterenol	TNFalpha	MESH:D007545	7124	Chemical	Gene	concentrations|amod|START_ENTITY concentrations|nmod|END_ENTITY	The release of soluble VAP-1 / SSAO by 3T3-L1 adipocytes is stimulated by isoproterenol and low concentrations of TNFalpha .
2994652	0	isoproterenol	41,54	VIP	91,94	isoproterenol	VIP	MESH:D007545	7432	Chemical	Gene	peptide|amod|START_ENTITY peptide|appos|END_ENTITY	Angiotensin_II and phorbol_ester enhance isoproterenol - and vasoactive intestinal peptide -LRB- VIP -RRB- - induced cyclic_AMP accumulation in vascular smooth muscle cells .
24192288	0	isoproterenol	11,24	aquaporin_5	28,39	isoproterenol	aquaporin 5	MESH:D007545	11830(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|amod|END_ENTITY	Effects of isoproterenol on aquaporin_5 levels in the parotid gland of mice in vivo .
2529784	0	isoproterenol	56,69	atrial_natriuretic_factor	11,36	isoproterenol	atrial natriuretic factor	MESH:D007545	608289(Tax:9615)	Chemical	Gene	Release|nmod|START_ENTITY Release|nmod|END_ENTITY	Release of atrial_natriuretic_factor during infusion of isoproterenol and angiotensin II .
1298296	0	isoproterenol	11,24	atrial_natriuretic_peptide	47,73	isoproterenol	atrial natriuretic peptide	MESH:D007545	4878	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|release release|nmod|END_ENTITY	Effects of isoproterenol -LRB- I -RRB- on the release of atrial_natriuretic_peptide -LRB- ANP -RRB- from isolated atria .
11125417	0	isoproterenol	20,33	beta3-adrenoceptor	48,66	isoproterenol	beta3-adrenoceptor	MESH:D007545	155	Chemical	Gene	agonists|amod|START_ENTITY agonists|amod|END_ENTITY	Relaxant effects of isoproterenol and selective beta3-adrenoceptor agonists on normal , low_compliant_and_hyperreflexic_human_bladders .
15892951	0	isoproterenol	52,65	cystatin_S	22,32	isoproterenol	cystatin S	MESH:D007545	296234(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Impaired induction of cystatin_S gene expression by isoproterenol in the submandibular gland of hypophysectomized rats .
16626506	0	isoproterenol	93,106	ghrelin	53,60	isoproterenol	ghrelin	MESH:D007545	59301(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|effects effects|nmod|END_ENTITY	Cardioprotective effects of ghrelin and des-octanoyl ghrelin on myocardial_injury induced by isoproterenol in rats .
8946341	0	isoproterenol	14,27	glucose_transporter	147,166	isoproterenol	glucose transporter	MESH:D007545	25139(Tax:10116)	Chemical	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|END_ENTITY	Comparison of isoproterenol with BRL37344 in activation of beta 3-adrenoceptors to inhibit the uptake of -LSB- 14C -RSB- deoxy-D-glucose and translocation of glucose_transporter -LRB- GLUT4 -RRB- to membrane fraction in rat adipocytes .
8428704	0	isoproterenol	96,109	lipoprotein_lipase	31,49	isoproterenol	lipoprotein lipase	MESH:D007545	24539(Tax:10116)	Chemical	Gene	infusion|nmod|START_ENTITY alterations|nmod|infusion alterations|nmod|activity activity|amod|END_ENTITY	Tissue-specific alterations in lipoprotein_lipase activity in the rat after chronic infusion of isoproterenol .
23887897	6	isoproterenol	759,772	mice	792,796	isoproterenol	b-AR	MESH:D007545	154	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|END_ENTITY	We hypothesized that isoproterenol treatment of young mice would provide a model system of cardiac pathology , and that nonselective b-AR blockade would provide benefit in adult , but not young , mice , similar to clinical trial data .
1965961	0	isoproterenol	81,94	mucin	19,24	isoproterenol	mucin	MESH:D007545	65202(Tax:10116)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Desensitization Desensitization|nmod|END_ENTITY	Desensitization of mucin secretion from rat submandibular tissues in response to isoproterenol .
899931	0	isoproterenol	47,60	parathyroid_hormone	14,33	isoproterenol	parathyroid hormone	MESH:D007545	5741	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of parathyroid_hormone secretion by isoproterenol .
2521333	0	isoproterenol	35,48	renin	76,81	isoproterenol	renin	MESH:D007545	5972	Chemical	Gene	release|amod|START_ENTITY release|compound|END_ENTITY	Atrial natriuretic factor inhibits isoproterenol - and furosemide-stimulated renin release in humans .
21263412	0	isoproterenol	72,85	troponin_I	32,42	isoproterenol	troponin I	MESH:D007545	29248(Tax:10116)	Chemical	Gene	administration|amod|START_ENTITY END_ENTITY|nmod|administration	Time-dependent responses of rat troponin_I and cardiac_injury following isoproterenol administration .
26338349	0	isopsoralen	55,66	cytochrome_P450_2B6	32,51	isopsoralen	cytochrome P450 2B6	MESH:C011659	1555	Chemical	Gene	inactivation|nmod|START_ENTITY inactivation|nmod|END_ENTITY	Mechanism-based inactivation of cytochrome_P450_2B6 by isopsoralen .
22530913	0	isoquinolin-1-one	66,83	TNFa	124,128	isoquinolin-1-one	TNFa	null	7124	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Generation of pharmacophore and atom based 3D-QSAR model of novel isoquinolin-1-one and quinazolin-4-one-type inhibitors of TNFa .
20443225	0	isoquinoline	27,39	CXCR4	40,45	isoquinoline	CXCR4	MESH:C039109	60628(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|antagonists antagonists|nummod|END_ENTITY	Synthesis and SAR of novel isoquinoline CXCR4 antagonists with potent anti-HIV activity .
23194502	0	isoquinoline_alkaloid	3,24	P-glycoprotein	93,107	isoquinoline alkaloid	P-glycoprotein	CHEBI:24921	5243	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	An isoquinoline_alkaloid from the Chinese herbal plant Corydalis yanhusuo W.T. Wang inhibits P-glycoprotein and multidrug_resistance-associate_protein_1 .
11961057	0	isoquinoline_alkaloid	12,33	inducible_nitric_oxide_synthase	121,152	isoquinoline alkaloid	inducible nitric oxide synthase	CHEBI:24921	18126(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|amod|END_ENTITY	A synthetic isoquinoline_alkaloid , 1 - -LRB- beta-naphthylmethyl -RRB- -6,7 - dihydroxy-1 ,2,3,4 - tetrahydroisoquinoline -LRB- YS_51 -RRB- , reduces inducible_nitric_oxide_synthase expression and improves survival in a rodent model of endotoxic_shock .
19969445	0	isoquinoline_alkaloids	10,32	acetylcholinesterase	74,94	isoquinoline alkaloids	acetylcholinesterase	CHEBI:24921	43	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|compound|END_ENTITY	Effect of isoquinoline_alkaloids from two Hippeastrum species on in vitro acetylcholinesterase activity .
3086939	0	isoquinoline_alkaloids	10,32	lipoxygenase	44,56	isoquinoline alkaloids	lipoxygenase	CHEBI:24921	547836(Tax:3847)	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of isoquinoline_alkaloids on soybean lipoxygenase activity in vitro .
12382020	0	isoquinoline_carboxamide	12,36	mitochondrial_benzodiazepine_receptor	51,88	isoquinoline carboxamide	mitochondrial benzodiazepine receptor	null	706	Chemical	Gene	ligand|amod|START_ENTITY ligand|nmod|END_ENTITY	PK11195 , an isoquinoline_carboxamide ligand of the mitochondrial_benzodiazepine_receptor , increased drug uptake and facilitated drug-induced apoptosis in human multidrug-resistant leukemia cells in vitro .
18501599	0	isoquinolinedione	32,49	insulin-like_growth_factor_receptor	64,99	isoquinolinedione	insulin-like growth factor receptor	null	3480	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Lead identification to generate isoquinolinedione inhibitors of insulin-like_growth_factor_receptor -LRB- IGF-1R -RRB- for potential use in cancer treatment .
21779981	0	isoquinolone	6,18	PDK1	19,23	isoquinolone	PDK1	null	5163	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Novel isoquinolone PDK1 inhibitors discovered through fragment-based lead discovery .
18313304	0	isoquinolones	50,63	JNK	94,97	isoquinolones	JNK	null	116554(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Discovery , synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors -LRB- 1 -RRB- .
18313930	0	isoquinolones	50,63	JNK	94,97	isoquinolones	JNK	null	116554(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Discovery , synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors -LRB- 2 -RRB- .
24972246	0	isorhamnetin	19,31	AMPK	0,4	isorhamnetin	AMPK	MESH:C047368	5563	Chemical	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	AMPK activation by isorhamnetin protects hepatocytes against oxidative stress and mitochondrial_dysfunction .
16226778	0	isorhamnetin	101,113	CYP1B1	165,171	isorhamnetin	CYP1B1	MESH:C047368	1545	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Effect of Ginkgo_biloba extract on procarcinogen-bioactivating human CYP1 enzymes : identification of isorhamnetin , kaempferol , and quercetin as potent inhibitors of CYP1B1 .
23162896	0	isorhamnetin	12,24	CYP3A4	28,34	isorhamnetin	CYP3A4	MESH:C047368	1576	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Effects of isorhamnetin on CYP3A4 and herb-drug interaction -RSB- .
22974546	0	isorhamnetin	45,57	TLR2/4	61,67	isorhamnetin	TLR2/4	MESH:C047368	24088;21898	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of the Miaoyao Fanggan sachet-derived isorhamnetin on TLR2/4 and NKp46 expression in mice .
12585121	0	isorhapotigenin	23,38	IL-8	42,46	isorhapotigenin	IL-8	null	3576	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	-LSB- Inhibitory effects of isorhapotigenin on IL-8 production and mRNA expression induced with TNF_alpha in normal human synovial cells -RSB- .
12585121	0	isorhapotigenin	23,38	TNF_alpha	91,100	isorhapotigenin	TNF alpha	null	7124	Chemical	Gene	START_ENTITY|nmod|production production|acl|induced induced|nmod|END_ENTITY	-LSB- Inhibitory effects of isorhapotigenin on IL-8 production and mRNA expression induced with TNF_alpha in normal human synovial cells -RSB- .
15963493	0	isorhynchophylline	23,41	5-HT2A_receptor	45,60	isorhynchophylline	5-HT2A receptor	MESH:C052714	15558(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|function function|amod|END_ENTITY	Suppressive effects of isorhynchophylline on 5-HT2A_receptor function in the brain : behavioural and electrophysiological studies .
2996791	0	isosafrole	37,47	cytochrome_P-450	17,33	isosafrole	cytochrome P-450	MESH:C015959	13079(Tax:10090)	Chemical	Gene	compounds|amod|START_ENTITY END_ENTITY|nmod|compounds	The induction of cytochrome_P-450 by isosafrole and related methylenedioxyphenyl compounds .
16699291	0	isosorbide	39,49	Antidiuretic_hormone	0,20	isosorbide	Antidiuretic hormone	MESH:D007547	551	Chemical	Gene	therapy|amod|START_ENTITY END_ENTITY|nmod|therapy	Antidiuretic_hormone and osmolality in isosorbide therapy and glycerol test .
25740261	0	isosorbide-5-mononitrate	17,41	CGRP	0,4	isosorbide-5-mononitrate	CGRP	MESH:C030397	796	Chemical	Gene	response|amod|START_ENTITY mediate|dobj|response mediate|nsubj|END_ENTITY	CGRP mediate the isosorbide-5-mononitrate cardiovascular response in healthy Chinese male volunteers through a XOR-independent pathway .
15619396	0	isosorbide_dinitrate	57,77	C-reactive_protein	99,117	isosorbide dinitrate	C-reactive protein	MESH:D007548	1401	Chemical	Gene	Effect|dep|START_ENTITY Effect|nmod|END_ENTITY	Effect of antispastic agents -LRB- calcium antagonists and/or isosorbide_dinitrate -RRB- on high-sensitivity C-reactive_protein in patients with coronary_vasospastic_angina_pectoris and no hemodynamically significant coronary_artery_disease .
11519419	0	isosorbide_dinitrate	8,28	angiotensin_II	48,62	isosorbide dinitrate	angiotensin II	MESH:D007548	183	Chemical	Gene	Use|nmod|START_ENTITY Use|nmod|END_ENTITY	-LSB- Use of isosorbide_dinitrate and antagonists of angiotensin_II in patients with stable_angina pectoris in early stages of cardiac_insufficiency -RSB- .
11150917	0	isosorbide_dinitrate	10,30	nitric_oxide_synthase	34,55	isosorbide dinitrate	nitric oxide synthase	MESH:D007548	4842	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of isosorbide_dinitrate on nitric_oxide_synthase under hypoxia .
18717331	0	isotetrandrine	19,33	doxorubicin-resistance	119,141	isotetrandrine	doxorubicin-resistance	MESH:C009438	5243	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|cells cells|amod|END_ENTITY	Reversal effect of isotetrandrine , an isoquinoline_alkaloid extracted from Caulis Mahoniae , on P-glycoprotein-mediated doxorubicin-resistance in human breast_cancer -LRB- MCF-7 / DOX -RRB- cells .
7957178	0	isothiazolones	55,69	interleukin-5	29,42	isothiazolones	interleukin-5	null	3567	Chemical	Gene	receptor|nmod|START_ENTITY receptor|amod|END_ENTITY	Covalent modification of the interleukin-5 receptor by isothiazolones leads to inhibition of the binding of interleukin-5 .
16506816	0	isothiocyanates	10,25	NF-kappaB	53,62	isothiocyanates	NF-kappaB	MESH:D017879	4790	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of isothiocyanates on nuclear accumulation of NF-kappaB , Nrf2 , and thioredoxin in caco-2 cells .
14604468	0	isothiocyanates	27,42	P-glycoprotein	75,89	isothiocyanates	P-glycoprotein	MESH:D017879	5243	Chemical	Gene	evaluation|nmod|START_ENTITY evaluation|nmod|END_ENTITY	Quantitative evaluation of isothiocyanates as substrates and inhibitors of P-glycoprotein .
22820176	0	isothiocyanates	39,54	TrxR1	0,5	isothiocyanates	TrxR1	MESH:D017879	7296	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	TrxR1 and GPx2 are potently induced by isothiocyanates and selenium , and mutually cooperate to protect Caco-2 cells against free radical-mediated cell death .
15989974	0	isothiocyanates	72,87	c-Jun	12,17	isothiocyanates	c-Jun	MESH:D017879	3725	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|role role|nmod|END_ENTITY	The role of c-Jun in the AP-1 activation induced by naturally occurring isothiocyanates .
11414690	0	isothiocyanates	44,59	cytochrome_P450_2E1	81,100	isothiocyanates	cytochrome P450 2E1	MESH:D017879	1571	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Differential effects of naturally occurring isothiocyanates on the activities of cytochrome_P450_2E1 and the mutant P450 2E1 T303A .
15215608	0	isothiocyanates	11,26	tumor_necrosis_factor-alpha	30,57	isothiocyanates	tumor necrosis factor-alpha	MESH:D017879	21926(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Effects of isothiocyanates on tumor_necrosis_factor-alpha production by J774A .1 -LRB- BALB/c macrophage -RRB- cells .
24888583	0	isotocin	56,64	Urotensin_II	0,12	isotocin	Urotensin II	MESH:C008215	10911	Chemical	Gene	release|compound|START_ENTITY inhibits|dobj|release inhibits|nsubj|END_ENTITY	Urotensin_II inhibits arginine_vasotocin and stimulates isotocin release from nerve endings in the pituitary of gilthead sea bream -LRB- Sparus aurata -RRB- .
20930691	0	isotretinoin	92,104	FoxO1	33,38	isotretinoin	FoxO1	MESH:D015474	2308	Chemical	Gene	action|compound|START_ENTITY role|nmod|action role|nmod|END_ENTITY	The role of transcription factor FoxO1 in the pathogenesis of acne_vulgaris and the mode of isotretinoin action .
19525031	0	isotretinoin	66,78	Retinoic_acid_4-hydroxylase	0,27	isotretinoin	Retinoic acid 4-hydroxylase	MESH:D015474	1592	Chemical	Gene	inducibility|nmod|START_ENTITY inducibility|compound|END_ENTITY	Retinoic_acid_4-hydroxylase inducibility and clinical response to isotretinoin in patients with acne .
7714084	0	isotretinoin	15,27	androgen_receptor	46,63	isotretinoin	androgen receptor	MESH:D015474	367	Chemical	Gene	treatment|compound|START_ENTITY treatment|nmod|levels levels|compound|END_ENTITY	Effect of oral isotretinoin treatment on skin androgen_receptor levels in male acneic patients .
10325581	0	isotretinoin	14,26	biotinidase	30,41	isotretinoin	biotinidase	MESH:D015474	686	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|amod|END_ENTITY	The effect of isotretinoin on biotinidase activity .
24720725	0	isotretinoin	92,104	hip	26,29	isotretinoin	hip	MESH:D015474	6159	Chemical	Gene	treatment|compound|START_ENTITY END_ENTITY|nmod|treatment	Avascular_necrosis of the hip and diffuse_idiopathic_skeletal_hyperostosis during long-term isotretinoin treatment of epidermolytic_ichthyosis due to a novel deletion mutation in KRT10 .
7723796	0	isotretinoin	97,109	retinoic_acid_receptor-beta	15,42	isotretinoin	retinoic acid receptor-beta	MESH:D015474	5915	Chemical	Gene	Suppression|nmod|START_ENTITY Suppression|nmod|END_ENTITY	Suppression of retinoic_acid_receptor-beta in premalignant_oral_lesions and its up-regulation by isotretinoin .
8165591	0	isotretinoin	10,22	tissue-type_plasminogen_activator	37,70	isotretinoin	tissue-type plasminogen activator	MESH:D015474	5327	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of isotretinoin on endogenous tissue-type_plasminogen_activator -LRB- t-PA -RRB- and plasminogen_activator_inhibitor_1 -LRB- PAI-1 -RRB- in humans .
24735646	0	isoxazole	78,87	DGAT1	112,117	isoxazole	DGAT1	CHEBI:35595	13350(Tax:10090)	Chemical	Gene	analogs|amod|START_ENTITY analogs|nmod|END_ENTITY	Synthesis and evaluation of cyclohexane_carboxylic_acid head group containing isoxazole and thiazole analogs as DGAT1 inhibitors .
19410460	0	isoxazole	12,21	farnesoid_X_receptor	33,53	isoxazole	farnesoid X receptor	CHEBI:35595	9971	Chemical	Gene	analogs|compound|START_ENTITY analogs|nmod|END_ENTITY	Substituted isoxazole analogs of farnesoid_X_receptor -LRB- FXR -RRB- agonist GW4064 .
26520661	0	isoxazole	64,73	soluble_epoxide_hydrolase	77,102	isoxazole	soluble epoxide hydrolase	CHEBI:35595	2053	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	1,3-Disubstituted _ and_1 ,3,3 - trisubstituted_adamantyl-ureas with isoxazole as soluble_epoxide_hydrolase inhibitors .
15380232	0	isoxazole_carboxamides	6,28	growth_hormone_secretagogue_receptor	32,68	isoxazole carboxamides	growth hormone secretagogue receptor	null	2693	Chemical	Gene	START_ENTITY|nmod|antagonists antagonists|amod|END_ENTITY	Novel isoxazole_carboxamides as growth_hormone_secretagogue_receptor -LRB- GHS-R -RRB- antagonists .
24332487	0	isoxazoles	27,37	c-jun_N-terminal_kinase	48,71	isoxazoles	c-jun N-terminal kinase	MESH:D007555	5599	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Synthesis and SAR of novel isoxazoles as potent c-jun_N-terminal_kinase -LRB- JNK -RRB- inhibitors .
16892352	0	isoxazoles	12,22	p38_MAP_kinase	47,61	isoxazoles	p38 MAP kinase	MESH:D007555	1432	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Substituted isoxazoles as potent inhibitors of p38_MAP_kinase .
10425086	0	isoxazoline	24,35	factor_Xa	51,60	isoxazoline	factor Xa	null	2159	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Design and synthesis of isoxazoline derivatives as factor_Xa inhibitors .
22414858	0	ispronicline	49,61	c-Fos	70,75	ispronicline	c-Fos	MESH:C490152	314322(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	The a4b2 nicotine acetylcholine receptor agonist ispronicline induces c-Fos expression in selective regions of the rat forebrain .
1533606	1	isradipine	188,198	ANP	210,213	isradipine	ANP	MESH:D017275	4878	Chemical	Gene	Effects|amod|START_ENTITY Effects|nmod|END_ENTITY	Effects of exercise and of the calcium antagonist , isradipine , on plasma ANP .
1380591	0	isradipine	11,21	renin	32,37	isradipine	renin	MESH:D017275	100358545(Tax:9986)	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Effects of isradipine on plasma renin activity in sodium-loaded and - depleted conscious rabbits .
24725292	0	istradefylline	34,48	Adenosine_A2A_receptor	0,22	istradefylline	Adenosine A2A receptor	MESH:C111599	135	Chemical	Gene	START_ENTITY|nsubj|antagonist antagonist|amod|END_ENTITY	Adenosine_A2A_receptor antagonist istradefylline 20 versus 40 mg/day as augmentation for Parkinson 's _ disease : a meta-analysis .
24488405	0	istradefylline	66,80	adenosine_A2A_receptor	31,53	istradefylline	adenosine A2A receptor	MESH:C111599	135	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Antidepressant activity of the adenosine_A2A_receptor antagonist , istradefylline -LRB- KW-6002 -RRB- on learned helplessness in rats .
26415982	0	istradefylline	39,53	adenosine_A2A_receptor	4,26	istradefylline	adenosine A2A receptor	MESH:C111599	100395031	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	The adenosine_A2A_receptor antagonist , istradefylline enhances anti-parkinsonian activity induced by combined treatment with low doses of L-DOPA and dopamine agonists in MPTP-treated common_marmosets .
10997945	0	itopride_hydrochloride	83,105	CYP3A4	59,65	itopride hydrochloride	CYP3A4	null	1576	Chemical	Gene	metabolism|nmod|START_ENTITY END_ENTITY|nmod|metabolism	The involvement of flavin-containing monooxygenase but not CYP3A4 in metabolism of itopride_hydrochloride , a gastroprokinetic agent : comparison with cisapride and mosapride_citrate .
10211916	0	itraconazole	11,23	CYP3A4	174,180	itraconazole	CYP3A4	MESH:D017964	1576	Chemical	Gene	concentrations|amod|START_ENTITY Effects|nmod|concentrations Effects|nmod|END_ENTITY	Effects of itraconazole on the steady-state plasma concentrations of haloperidol and its reduced metabolite in schizophrenic patients : in vivo evidence of the involvement of CYP3A4 for haloperidol metabolism .
15232663	0	itraconazole	44,56	CYP3A4	100,106	itraconazole	CYP3A4	MESH:D017964	1576	Chemical	Gene	etizolam|nmod|START_ENTITY metabolism|nmod|etizolam Inhibition|nmod|metabolism Inhibition|dep|evidence evidence|nmod|involvement involvement|nmod|END_ENTITY	Inhibition of the metabolism of etizolam by itraconazole in humans : evidence for the involvement of CYP3A4 in etizolam metabolism .
15242978	0	itraconazole	8,20	CYP3A4	36,42	itraconazole	CYP3A4	MESH:D017964	1576	Chemical	Gene	Role|nmod|START_ENTITY metabolites|nsubj|Role metabolites|nmod|inhibition inhibition|compound|END_ENTITY	Role of itraconazole metabolites in CYP3A4 inhibition .
17386084	0	itraconazole	77,89	CYP3A4	60,66	itraconazole	CYP3A4	MESH:D017964	1576	Chemical	Gene	START_ENTITY|nsubj|inhibitor inhibitor|compound|END_ENTITY	Dynamically simulating the interaction of midazolam and the CYP3A4 inhibitor itraconazole using individual coupled whole-body physiologically-based pharmacokinetic -LRB- WB-PBPK -RRB- models .
17495874	0	itraconazole	16,28	CYP3A4	58,64	itraconazole	CYP3A4	MESH:D017964	1576	Chemical	Gene	Contribution|nmod|START_ENTITY metabolites|nsubj|Contribution metabolites|xcomp|inhibition inhibition|nmod|END_ENTITY	Contribution of itraconazole metabolites to inhibition of CYP3A4 in vivo .
19954708	0	itraconazole	79,91	CYP3A4	40,46	itraconazole	CYP3A4	MESH:D017964	1576	Chemical	Gene	effects|nmod|START_ENTITY inhibition|dep|effects inhibition|amod|4beta-hydroxycholesterol 4beta-hydroxycholesterol|nmod|marker marker|nmod|END_ENTITY	4beta-hydroxycholesterol as a marker of CYP3A4 inhibition in vivo - effects of itraconazole in man .
20739919	0	itraconazole	59,71	CYP3A4	38,44	itraconazole	CYP3A4	MESH:D017964	1576	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|prediction prediction|nmod|END_ENTITY	Accurate prediction of dose-dependent CYP3A4 inhibition by itraconazole and its metabolites from in vitro inhibition data .
26655341	0	itraconazole	16,28	VDAC1	37,42	itraconazole	VDAC1	MESH:D017964	7416	Chemical	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells .
20130764	0	itraconazole	41,53	cytochrome_p450	11,26	itraconazole	cytochrome p450	MESH:D017964	25251(Tax:10116)	Chemical	Gene	inhibitors|nmod|START_ENTITY inhibitors|amod|END_ENTITY	Effects of cytochrome_p450 inhibitors on itraconazole and fluconazole induced cytotoxicity in hepatocytes .
12595750	0	itraconazole	53,65	interleukin_6	10,23	itraconazole	interleukin 6	MESH:D017964	3569	Chemical	Gene	metabolism|nmod|START_ENTITY END_ENTITY|nmod|metabolism	Effect of interleukin_6 on the hepatic metabolism of itraconazole and its metabolite hydroxyitraconazole using primary human hepatocytes .
25911606	0	ivabradine	79,89	hERG	0,4	ivabradine	hERG	MESH:C088408	2078	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|blockade blockade|amod|END_ENTITY	hERG potassium channel blockade by the HCN channel inhibitor bradycardic agent ivabradine .
26275355	0	ivabradine	37,47	hERG	0,4	ivabradine	hERG	MESH:C088408	2078	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	hERG potassium channel inhibition by ivabradine requires channel gating .
26301071	0	ivabradine	37,47	hERG	0,4	ivabradine	hERG	MESH:C088408	2078	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	hERG potassium channel inhibition by ivabradine may contribute to QT_prolongation and risk of torsades_de_pointes .
8949985	0	ivermectin	25,35	P-glycoprotein	48,62	ivermectin	P-glycoprotein	MESH:D007559	67078(Tax:10090)	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|amod|END_ENTITY	The abamectin derivative ivermectin is a potent P-glycoprotein inhibitor .
23086000	0	ivermectin	69,79	Rab5	0,4	ivermectin	Rab5	MESH:D007559	5868	Chemical	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Rab5 regulates internalisation of P2X4 receptors and potentiation by ivermectin .
3426112	0	ivermectin	17,27	milk	31,35	ivermectin	milk	MESH:D007559	100532204	Chemical	Gene	Determination|nmod|START_ENTITY Determination|nmod|END_ENTITY	Determination of ivermectin in milk by high performance liquid chromatography .
16384552	0	ivermectin	15,25	multidrug_resistance_proteins	31,60	ivermectin	multidrug resistance proteins	MESH:D007559	4363	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of ivermectin with multidrug_resistance_proteins -LRB- MRP1 , _ 2_and_3 -RRB- .
16817319	0	jacalin	112,119	caveolin-1	34,44	jacalin	caveolin-1	null	857	Chemical	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	Stress-induced phosphorylation of caveolin-1 and p38 , and down-regulation of EGFr and ERK by the dietary lectin jacalin in two human carcinoma cell lines .
26309036	0	jadomycin_DS	35,47	topoisomerase_IIb	57,74	jadomycin DS	topoisomerase IIb	null	7155	Chemical	Gene	binding|nmod|START_ENTITY binding|nmod|END_ENTITY	Investigations into the binding of jadomycin_DS to human topoisomerase_IIb by WaterLOGSY NMR spectroscopy .
18458331	0	jasmonate	47,56	COI1	0,4	jasmonate	COI1	MESH:C011006	543911(Tax:4081)	Chemical	Gene	receptor|nmod|START_ENTITY component|nmod|receptor component|nsubj|END_ENTITY	COI1 is a critical component of a receptor for jasmonate and the bacterial virulence factor coronatine .
20699268	0	jasmonate	8,17	COI1	0,4	jasmonate	COI1	MESH:C011006	818581(Tax:3702)	Chemical	Gene	receptor|amod|START_ENTITY END_ENTITY|appos|receptor	COI1 , a jasmonate receptor , is involved in ethylene-induced inhibition of Arabidopsis root growth in the light .
23093946	0	jasmonic_acid	45,58	COI1	71,75	jasmonic acid	COI1	MESH:C011006	818581(Tax:3702)	Chemical	Gene	START_ENTITY|ccomp|regulate regulate|nsubj|END_ENTITY	Specific missense alleles of the arabidopsis jasmonic_acid co-receptor COI1 regulate innate immune receptor accumulation and function .
22846509	0	juxtamembrane_tryptophans	10,35	Synaptobrevin	62,75	juxtamembrane tryptophans	Synaptobrevin	null	36080(Tax:7227)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of juxtamembrane_tryptophans on the immersion depth of Synaptobrevin , an integral vesicle membrane protein .
15013846	0	kaempferol	66,76	ERK	145,148	kaempferol	ERK	MESH:C006552	5594	Chemical	Gene	START_ENTITY|nmod|activity activity|acl|MG-63 MG-63|nmod|END_ENTITY	Stimulatory effect of naturally occurring flavonols quercetin and kaempferol on alkaline_phosphatase activity in MG-63 human osteoblasts through ERK and estrogen receptor pathway .
25177032	0	kaempferol	25,35	MUC5AC	99,105	kaempferol	MUC5AC	MESH:C006552	4586	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|nmod|END_ENTITY	Cytoprotective effect of kaempferol on paraquat-exposed BEAS-2B cells via modulating expression of MUC5AC .
22819546	0	kaempferol	15,25	PDX-1	36,41	kaempferol	PDX-1	MESH:C006552	3651	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|compound|END_ENTITY	Small molecule kaempferol modulates PDX-1 protein expression and subsequently promotes pancreatic b-cell survival and function via CREB .
25434138	0	kaempferol	14,24	TGF-b1	28,34	kaempferol	TGF-b1	MESH:C006552	21803(Tax:10090)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	-LSB- Influence of kaempferol on TGF-b1 / Smads signal path in liver tissue of mice with Schistosoma_japonicum infection -RSB- .
25507736	0	kaempferol	14,24	TGF-b1	28,34	kaempferol	TGF-b1	MESH:C006552	21803(Tax:10090)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	-LSB- Influence of kaempferol on TGF-b1 / Smads signal path in liver tissue of mice with Schistosoma_japonicum infection -RSB- .
15013846	0	kaempferol	66,76	alkaline_phosphatase	80,100	kaempferol	alkaline phosphatase	MESH:C006552	250	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Stimulatory effect of naturally occurring flavonols quercetin and kaempferol on alkaline_phosphatase activity in MG-63 human osteoblasts through ERK and estrogen receptor pathway .
14603522	0	kaempferol	80,90	estrogen_receptor_alpha	14,37	kaempferol	estrogen receptor alpha	MESH:C006552	2099	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|expression expression|compound|END_ENTITY	Inhibition of estrogen_receptor_alpha expression and function in MCF-7 cells by kaempferol .
17278014	0	kaempferol	52,62	iNOS	19,23	kaempferol	iNOS	MESH:C006552	24599(Tax:10116)	Chemical	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|nmod|END_ENTITY	Down-regulation of iNOS and TNF-alpha expression by kaempferol via NF-kappaB inactivation in aged rat gingival tissues .
15225655	0	kahweol	27,34	cyclooxygenase-2	51,67	kahweol	cyclooxygenase-2	MESH:C053401	5743	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Suppressive effects of the kahweol and cafestol on cyclooxygenase-2 expression in macrophages .
15275825	0	kainate	51,58	CA1	119,122	kainate	CA1	MESH:D007608	310218(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|region region|compound|END_ENTITY	Characterisation of the effects of ATPA , a GLU -LRB- K5 -RRB- kainate receptor agonist , on GABAergic synaptic transmission in the CA1 region of rat hippocampal slices .
3538812	0	kainate	11,18	CA1	22,25	kainate	CA1	MESH:D007608	759	Chemical	Gene	START_ENTITY|nmod|neurons neurons|nummod|END_ENTITY	Effects of kainate on CA1 hippocampal neurons recorded in vitro .
9517417	0	kainate	48,55	CA3	73,76	kainate	CA3	MESH:D007608	54232(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY receptor|nmod|END_ENTITY	The synaptic activation of the GluR5 subtype of kainate receptor in area CA3 of the rat hippocampus .
15869941	0	kainate	144,151	Ca-A/K	153,159	kainate	Ca-A/K	MESH:D007608	10194;780	Chemical	Gene	channels|compound|START_ENTITY channels|appos|END_ENTITY	Tumor_necrosis-factor-alpha -LRB- TNF-alpha -RRB- induces rapid insertion of Ca2 + - permeable alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate -LRB- AMPA -RRB- / kainate -LRB- Ca-A/K -RRB- channels in a subset of hippocampal_pyramidal_neurons .
17348638	0	kainate	207,214	GLUK5	201,206	kainate	GLUK5	MESH:D007608	2901	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|amod|END_ENTITY	Synthesis and pharmacological characterization of N3-substituted_willardiine derivatives : role of the substituent at the 5-position of the uracil ring in the development of highly potent and selective GLUK5 kainate receptor antagonists .
11702055	0	kainate	48,55	GRIK1	71,76	kainate	GRIK1	MESH:D007608	2897	Chemical	Gene	gene|amod|START_ENTITY polymorphisms|nmod|gene study|nmod|polymorphisms study|appos|END_ENTITY	Association study of polymorphisms in the GluR5 kainate receptor gene -LRB- GRIK1 -RRB- with schizophrenia .
9259378	0	kainate	62,69	GRIK1	85,90	kainate	GRIK1	MESH:D007608	2897	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Allelic association of juvenile_absence_epilepsy with a GluR5 kainate receptor gene -LRB- GRIK1 -RRB- polymorphism .
12467946	0	kainate	48,55	GRIK2	71,76	kainate	GRIK2	MESH:D007608	2898	Chemical	Gene	gene|amod|START_ENTITY polymorphisms|nmod|gene study|nmod|polymorphisms study|appos|END_ENTITY	Association study of polymorphisms in the GluR6 kainate receptor gene -LRB- GRIK2 -RRB- with schizophrenia .
18332879	0	kainate	36,43	GRIK2	68,73	kainate	GRIK2	MESH:D007608	14806(Tax:10090)	Chemical	Gene	GluR6|amod|START_ENTITY involvement|nmod|GluR6 Evidence|nmod|involvement Evidence|appos|END_ENTITY	Evidence for the involvement of the kainate receptor subunit GluR6 -LRB- GRIK2 -RRB- in mediating behavioral_displays related to behavioral symptoms of mania .
7675232	0	kainate	46,53	GRIK2	69,74	kainate	GRIK2	MESH:D007608	2898	Chemical	Gene	START_ENTITY|dobj|gene gene|appos|END_ENTITY	Refinement of map position of the human GluR6 kainate receptor gene -LRB- GRIK2 -RRB- and lack of association and linkage with idiopathic_generalized_epilepsies .
8034316	0	kainate	12,19	GRIK2	30,35	kainate	GRIK2	MESH:D007608	2898	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Human GluR6 kainate receptor -LRB- GRIK2 -RRB- : molecular cloning , expression , polymorphism , and chromosomal assignment .
16958029	0	kainate	25,32	GRIK3	54,59	kainate	GRIK3	MESH:D007608	2899	Chemical	Gene	gene|amod|START_ENTITY Association|nmod|gene Association|appos|END_ENTITY	Association of the human kainate receptor GluR7 gene -LRB- GRIK3 -RRB- with recurrent major_depressive_disorder .
19417176	0	kainate	100,107	GluK1	86,91	kainate	GluK1	MESH:D007608	29559(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY END_ENTITY|dobj|receptors	Topiramate reduces excitability in the basolateral amygdala by selectively inhibiting GluK1 -LRB- GluR5 -RRB- kainate receptors on interneurons and positively modulating GABAA receptors on principal neurons .
21324591	0	kainate	75,82	GluK1	69,74	kainate	GluK1	MESH:D007608	14805(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Antinociceptive effects of MSVIII-19 , a functional antagonist of the GluK1 kainate receptor .
21593317	0	kainate	54,61	GluK1	48,53	kainate	GluK1	MESH:D007608	2897	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Synaptic targeting and functional modulation of GluK1 kainate receptors by the auxiliary neuropilin and tolloid-like -LRB- NETO -RRB- proteins .
21619066	0	kainate	10,17	GluK1	28,33	kainate	GluK1	MESH:D007608	2897	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Selective kainate receptor -LRB- GluK1 -RRB- ligands structurally based upon 1H-cyclopentapyrimidin-2 ,4 -LRB- 1H ,3 H -RRB- - dione : synthesis , molecular modeling , and pharmacological and biostructural characterization .
22191429	0	kainate	53,60	GluK1	47,52	kainate	GluK1	MESH:D007608	2897	Chemical	Gene	START_ENTITY|nsubj|mechanism mechanism|nmod|END_ENTITY	Channel-opening kinetic mechanism of wild-type GluK1 kainate receptors and a C-terminal mutant .
22516108	0	kainate	113,120	GluK1	19,24	kainate	GluK1	MESH:D007608	29559(Tax:10116)	Chemical	Gene	pathway|amod|START_ENTITY inhibiting|dobj|pathway ischemic_neuronal_injury|advcl|inhibiting receptors|amod|ischemic_neuronal_injury ATPA|nmod|receptors agonist|dobj|ATPA agonist|nsubj|Neuroprotection Neuroprotection|nmod|receptor receptor|amod|END_ENTITY	Neuroprotection of GluK1 kainate receptor agonist ATPA against ischemic_neuronal_injury through inhibiting GluK2 kainate receptor-JNK3 pathway via GABA -LRB- A -RRB- receptors .
22516108	0	kainate	25,32	GluK1	19,24	kainate	GluK1	MESH:D007608	29559(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Neuroprotection of GluK1 kainate receptor agonist ATPA against ischemic_neuronal_injury through inhibiting GluK2 kainate receptor-JNK3 pathway via GABA -LRB- A -RRB- receptors .
23786569	0	kainate	15,22	GluK1	9,14	kainate	GluK1	MESH:D007608	14805(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Cortical GluK1 kainate receptors modulate scratching in adult mice .
24760837	0	kainate	14,21	GluK1	8,13	kainate	GluK1	MESH:D007608	14805(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of GluK1 kainate receptors in seizures , epileptic discharges , and epileptogenesis .
19596362	0	kainate	25,32	GluK2	19,24	kainate	GluK2	MESH:D007608	14806(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Down-regulation Down-regulation|nmod|END_ENTITY	Down-regulation of GluK2 kainate receptor expression by chronic treatment with mood-stabilizing anti-convulsants or lithium in cultured astrocytes and brain , but not in neurons .
20404149	0	kainate	50,57	GluK2	36,41	kainate	GluK2	MESH:D007608	2898	Chemical	Gene	receptors|amod|START_ENTITY subtype|dobj|receptors subtype|nsubj|organization organization|nmod|END_ENTITY	Domain organization and function in GluK2 subtype kainate receptors .
20805577	0	kainate	51,58	GluK2	45,50	kainate	GluK2	MESH:D007608	2898	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Fatty_acid modulation and polyamine block of GluK2 kainate receptors analyzed by scanning mutagenesis .
22483987	0	kainate	115,122	GluK2	44,49	kainate	GluK2	MESH:D007608	54257(Tax:10116)	Chemical	Gene	stimulation|amod|START_ENTITY pathway|nmod|stimulation activation|nmod|pathway contributes|nmod|activation contributes|nsubj|SUMOylation SUMOylation|nmod|END_ENTITY	SUMOylation of the kainate receptor subunit GluK2 contributes to the activation of the MLK3-JNK3 pathway following kainate stimulation .
22516108	0	kainate	113,120	GluK2	107,112	kainate	GluK2	MESH:D007608	54257(Tax:10116)	Chemical	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	Neuroprotection of GluK1 kainate receptor agonist ATPA against ischemic_neuronal_injury through inhibiting GluK2 kainate receptor-JNK3 pathway via GABA -LRB- A -RRB- receptors .
22516108	0	kainate	25,32	GluK2	107,112	kainate	GluK2	MESH:D007608	54257(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY Neuroprotection|nmod|receptor agonist|nsubj|Neuroprotection agonist|dobj|ATPA ATPA|nmod|receptors receptors|amod|ischemic_neuronal_injury ischemic_neuronal_injury|advcl|inhibiting inhibiting|dobj|pathway pathway|amod|END_ENTITY	Neuroprotection of GluK1 kainate receptor agonist ATPA against ischemic_neuronal_injury through inhibiting GluK2 kainate receptor-JNK3 pathway via GABA -LRB- A -RRB- receptors .
22522402	0	kainate	50,57	GluK2	35,40	kainate	GluK2	MESH:D007608	54257(Tax:10116)	Chemical	Gene	trafficking|amod|START_ENTITY regulate|dobj|trafficking regulate|nsubj|SUMOylation SUMOylation|nmod|END_ENTITY	SUMOylation and phosphorylation of GluK2 regulate kainate receptor trafficking and synaptic plasticity .
23940260	0	kainate	49,56	GluK2	43,48	kainate	GluK2	MESH:D007608	2898	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Q/R site interactions with the M3 helix in GluK2 kainate receptor channels revealed by thermodynamic mutant cycles .
25201974	0	kainate	47,54	GluK2	28,33	kainate	GluK2	MESH:D007608	54257(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|phosphorylation phosphorylation|nmod|up-regulates up-regulates|amod|END_ENTITY	Tyrosine phosphorylation of GluK2 up-regulates kainate receptor-mediated responses and downstream signaling after brain_ischemia .
25316086	0	kainate	17,24	GluK2	59,64	kainate	GluK2	MESH:D007608	14806(Tax:10090)	Chemical	Gene	receptors|amod|START_ENTITY regulates|dobj|receptors regulates|advcl|interacting interacting|nmod|subunit subunit|amod|END_ENTITY	Parkin regulates kainate receptors by interacting with the GluK2 subunit .
22203159	0	kainate	30,37	GluK4	24,29	kainate	GluK4	MESH:D007608	110637(Tax:10090)	Chemical	Gene	subunit|amod|START_ENTITY subunit|amod|END_ENTITY	Genetic ablation of the GluK4 kainate receptor subunit causes anxiolytic and antidepressant-like behavior in mice .
23357115	0	kainate	10,17	GluK4	4,9	kainate	GluK4	MESH:D007608	2900	Chemical	Gene	subunit|amod|START_ENTITY subunit|amod|END_ENTITY	The GluK4 kainate receptor subunit regulates memory , mood , and excitotoxic neurodegeneration .
23288040	0	kainate	65,72	GluK5	36,41	kainate	GluK5	MESH:D007608	2901	Chemical	Gene	receptors|amod|START_ENTITY plasticity|nmod|receptors mediates|dobj|plasticity mediates|nsubj|phosphorylation phosphorylation|nmod|END_ENTITY	CaMKII-dependent phosphorylation of GluK5 mediates plasticity of kainate receptors .
23975096	0	kainate	112,119	GluK5	23,28	kainate	GluK5	MESH:D007608	2901	Chemical	Gene	receptors|compound|START_ENTITY expression|nmod|receptors sufficient|nmod|expression sufficient|nsubj|Agonist Agonist|nmod|subunit subunit|amod|END_ENTITY	Agonist binding to the GluK5 subunit is sufficient for functional surface expression of heteromeric GluK2/GluK5 kainate receptors .
24859608	0	kainate	61,68	GluK5	78,83	kainate	GluK5	MESH:D007608	2901	Chemical	Gene	subunit|amod|START_ENTITY subunit|compound|END_ENTITY	The neurotoxin domoate causes long-lasting inhibition of the kainate receptor GluK5 subunit .
10196544	0	kainate	6,13	GluR5	0,5	kainate	GluR5	MESH:D007608	2897	Chemical	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	GluR5 kainate receptor activation in interneurons increases tonic inhibition of pyramidal cells .
10493729	0	kainate	12,19	GluR5	58,63	kainate	GluR5	MESH:D007608	2897	Chemical	Gene	receptors|compound|START_ENTITY formed|nsubj|receptors formed|nmod|coassembly coassembly|nmod|END_ENTITY	Heteromeric kainate receptors formed by the coassembly of GluR5 , GluR6 , and GluR7 .
10608276	0	kainate	43,50	GluR5	37,42	kainate	GluR5	MESH:D007608	29559(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	-LSB- 3H -RSB- ATPA : a high affinity ligand for GluR5 kainate receptors .
10821708	0	kainate	64,71	GluR5	58,63	kainate	GluR5	MESH:D007608	2897	Chemical	Gene	agonists|amod|START_ENTITY agonists|amod|END_ENTITY	4-Alkyl - _ and_4-cinnamylglutamic_acid analogues are potent GluR5 kainate receptor agonists .
12091575	0	kainate	57,64	GluR5	40,45	kainate	GluR5	MESH:D007608	2897	Chemical	Gene	receptors|amod|START_ENTITY effects|nmod|receptors effects|nmod|agonist agonist|amod|END_ENTITY	Paradoxical anti-epileptic effects of a GluR5 agonist of kainate receptors .
12238915	0	kainate	127,134	GluR5	121,126	kainate	GluR5	MESH:D007608	2897	Chemical	Gene	antagonist|amod|START_ENTITY antagonist|amod|END_ENTITY	Ethyl _ -LRB- 3S ,4 aR ,6 S ,8 aR -RRB- -6 - -LRB- 4-ethoxycar - _ bonylimidazol-1-ylmethyl -RRB- decahydroiso-quinoline-3-carboxylic_ester : a prodrug of a GluR5 kainate receptor antagonist active in two animal models of acute migraine .
12243762	0	kainate	42,49	GluR5	36,41	kainate	GluR5	MESH:D007608	29559(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Modulation of spinal nociception by GluR5 kainate receptor ligands in acute and hyperalgesic states and the role of gabaergic mechanisms .
15111016	0	kainate	74,81	GluR5	68,73	kainate	GluR5	MESH:D007608	14805(Tax:10090)	Chemical	Gene	agonist|amod|START_ENTITY agonist|amod|END_ENTITY	Topiramate selectively protects against seizures induced by ATPA , a GluR5 kainate receptor agonist .
15327819	0	kainate	16,23	GluR5	24,29	kainate	GluR5	MESH:D007608	2897	Chemical	Gene	antagonist|amod|START_ENTITY antagonist|amod|END_ENTITY	The effect of a kainate GluR5 receptor antagonist on responses of spinothalamic tract neurons in a model of peripheral_neuropathy in primates .
15509753	0	kainate	23,30	GluR5	49,54	kainate	GluR5	MESH:D007608	14805(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY roles|nmod|receptor subunits|nsubj|roles subunits|dobj|END_ENTITY	Distinct roles for the kainate receptor subunits GluR5 and GluR6 in kainate-induced hippocampal_gamma_oscillations .
15710405	0	kainate	25,32	GluR5	42,47	kainate	GluR5	MESH:D007608	2897	Chemical	Gene	receptor|amod|START_ENTITY structure|nmod|receptor END_ENTITY|nsubj|structure	Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with -LRB- S -RRB- - glutamate .
15721240	0	kainate	96,103	GluR5	26,31	kainate	GluR5	MESH:D007608	2897	Chemical	Gene	selectivity|amod|START_ENTITY mechanisms|dep|selectivity cores|dep|mechanisms ligand|dobj|cores ligand|nsubj|structures structures|nmod|END_ENTITY	Crystal structures of the GluR5 and GluR6 ligand binding cores : molecular mechanisms underlying kainate receptor selectivity .
15974569	0	kainate	43,50	GluR5	37,42	kainate	GluR5	MESH:D007608	2897	Chemical	Gene	START_ENTITY|nsubj|prodrugs prodrugs|nmod|END_ENTITY	Two prodrugs of potent and selective GluR5 kainate receptor antagonists actives in three animal models of pain .
19123252	0	kainate	97,104	GluR5	91,96	kainate	GluR5	MESH:D007608	29559(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Age-dependent enhancement of inhibitory synaptic transmission in CA1 pyramidal neurons via GluR5 kainate receptors .
19136046	0	kainate	113,120	GluR5	107,112	kainate	GluR5	MESH:D007608	29559(Tax:10116)	Chemical	Gene	antagonist|amod|START_ENTITY antagonist|amod|END_ENTITY	Soman induces ictogenesis in the amygdala and interictal activity in the hippocampus that are blocked by a GluR5 kainate receptor antagonist in vitro .
19320626	0	kainate	53,60	GluR5	47,52	kainate	GluR5	MESH:D007608	2897	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Association of markers in the 3 ' region of the GluR5 kainate receptor subunit gene to alcohol_dependence .
19417176	0	kainate	100,107	GluR5	93,98	kainate	GluR5	MESH:D007608	29559(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Topiramate reduces excitability in the basolateral amygdala by selectively inhibiting GluK1 -LRB- GluR5 -RRB- kainate receptors on interneurons and positively modulating GABAA receptors on principal neurons .
20513362	0	kainate	26,33	GluR5	20,25	kainate	GluR5	MESH:D007608	14805(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Postnatal change of GluR5 kainate receptor expression in the substantia gelatinosa neuron of the trigeminal subnucleus caudalis in mice .
7512622	0	kainate	75,82	GluR5	59,64	kainate	GluR5	MESH:D007608	29559(Tax:10116)	Chemical	Gene	START_ENTITY|csubj|Assessing Assessing|dobj|extent extent|nmod|editing editing|nmod|regions regions|nmod|END_ENTITY	Assessing the extent of RNA editing in the TMII regions of GluR5 and GluR6 kainate receptors during rat brain development .
8609884	0	kainate	50,57	GluR5	34,39	kainate	GluR5	MESH:D007608	2897	Chemical	Gene	START_ENTITY|nsubj|discrimination discrimination|nmod|END_ENTITY	Pharmacological discrimination of GluR5 and GluR6 kainate receptor subtypes by -LRB- 3S ,4 aR ,6 R ,8 aR -RRB- -6 - -LSB- 2 - -LRB- 1 -LRB- 2 -RRB- H-tetrazole-5-yl -RRB- ethyl -RSB- decahyd_roisdoquinoline-3_carboxylic-acid .
9259378	0	kainate	62,69	GluR5	56,61	kainate	GluR5	MESH:D007608	2897	Chemical	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Allelic association of juvenile_absence_epilepsy with a GluR5 kainate receptor gene -LRB- GRIK1 -RRB- polymorphism .
9335499	0	kainate	20,27	GluR5	14,19	kainate	GluR5	MESH:D007608	2897	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission .
9354337	0	kainate	90,97	GluR5	74,79	kainate	GluR5	MESH:D007608	2897	Chemical	Gene	START_ENTITY|nsubj|Identification Identification|nmod|residues residues|acl:relcl|control control|dobj|behavior behavior|nmod|END_ENTITY	Identification of amino_acid residues that control functional behavior in GluR5 and GluR6 kainate receptors .
9517417	0	kainate	48,55	GluR5	31,36	kainate	GluR5	MESH:D007608	29559(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY subtype|nmod|receptor subtype|amod|END_ENTITY	The synaptic activation of the GluR5 subtype of kainate receptor in area CA3 of the rat hippocampus .
9824706	0	kainate	33,40	GluR5	27,32	kainate	GluR5	MESH:D007608	2897	Chemical	Gene	START_ENTITY|nsubj|Heterogeneity Heterogeneity|nmod|END_ENTITY	Heterogeneity of homomeric GluR5 kainate receptor desensitization expressed in HEK293 cells .
9849663	0	kainate	18,25	GluR5	12,17	kainate	GluR5	MESH:D007608	2897	Chemical	Gene	agonist|amod|START_ENTITY agonist|amod|END_ENTITY	LY339434 , a GluR5 kainate receptor agonist .
9849664	0	kainate	21,28	GluR5	4,9	kainate	GluR5	MESH:D007608	29559(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY subtype|nmod|receptor subtype|amod|END_ENTITY	The GluR5 subtype of kainate receptor regulates excitatory synaptic transmission in areas CA1 and CA3 of the rat hippocampus .
9849665	0	kainate	6,13	GluR5	0,5	kainate	GluR5	MESH:D007608	29559(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	GluR5 kainate receptor mediated synaptic transmission in rat basolateral amygdala in vitro .
10493110	0	kainate	44,51	GluR6	38,43	kainate	GluR6	MESH:D007608	54257(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Pharmacological characterization of a GluR6 kainate receptor in cultured hippocampal neurons .
10704492	0	kainate	17,24	GluR6	11,16	kainate	GluR6	MESH:D007608	14806(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Functional GluR6 kainate receptors in the striatum : indirect downregulation of synaptic transmission .
10768301	0	kainate	25,32	GluR6	90,95	kainate	GluR6	MESH:D007608	2898	Chemical	Gene	ion|amod|START_ENTITY topiramate|nmod|ion Effects|nmod|topiramate flux|nsubj|Effects flux|nmod|channels channels|amod|END_ENTITY	Effects of topiramate on kainate - and domoate-activated -LSB- 14C -RSB- guanidinium ion flux through GluR6 channels in transfected BHK cells using Cytostar-T scintillating microplates .
14567698	0	kainate	34,41	GluR6	28,33	kainate	GluR6	MESH:D007608	2898	Chemical	Gene	START_ENTITY|nsubj|kinetics kinetics|nmod|END_ENTITY	Channel-opening kinetics of GluR6 kainate receptor .
14736854	0	kainate	34,41	GluR6	28,33	kainate	GluR6	MESH:D007608	2898	Chemical	Gene	START_ENTITY|nsubj|determinant determinant|nmod|END_ENTITY	A C-terminal determinant of GluR6 kainate receptor trafficking .
15677325	0	kainate	17,24	GluR6	42,47	kainate	GluR6	MESH:D007608	2898	Chemical	Gene	receptor|amod|START_ENTITY Structure|nmod|receptor subunit|nsubj|Structure subunit|dobj|domain domain|amod|END_ENTITY	Structure of the kainate receptor subunit GluR6 agonist-binding domain complexed with domoic_acid .
15976221	0	kainate	82,89	GluR6	75,80	kainate	GluR6	MESH:D007608	14806(Tax:10090)	Chemical	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The effect of three inhaled anesthetics in mice harboring mutations in the GluR6 -LRB- kainate -RRB- receptor gene .
16439423	0	kainate	82,89	GluR6	76,81	kainate	GluR6	MESH:D007608	2898	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Concanavalin-A reports agonist-induced conformational changes in the intact GluR6 kainate receptor .
17062563	0	kainate	54,61	GluR6	48,53	kainate	GluR6	MESH:D007608	14806(Tax:10090)	Chemical	Gene	subunits|amod|START_ENTITY subunits|amod|END_ENTITY	Actinfilin is a Cul3 substrate adaptor , linking GluR6 kainate receptor subunits to the ubiquitin-proteasome pathway .
17167233	0	kainate	31,38	GluR6	48,53	kainate	GluR6	MESH:D007608	2898	Chemical	Gene	receptor|amod|START_ENTITY significance|nmod|receptor END_ENTITY|nsubj|significance	Functional significance of the kainate receptor GluR6 -LRB- M836I -RRB- mutation that is linked to autism .
18664604	0	kainate	17,24	GluR6	42,47	kainate	GluR6	MESH:D007608	2898	Chemical	Gene	receptor|amod|START_ENTITY Mutations|nmod|receptor subunit|nsubj|Mutations subunit|dobj|pocket pocket|amod|END_ENTITY	Mutations to the kainate receptor subunit GluR6 binding pocket that selectively affect domoate binding .
18690046	0	kainate	62,69	GluR6	56,61	kainate	GluR6	MESH:D007608	2898	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Functional consequences of natural substitutions in the GluR6 kainate receptor subunit ligand-binding site .
18692513	0	kainate	76,83	GluR6	70,75	kainate	GluR6	MESH:D007608	2898	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	The BTB/kelch protein , KRIP6 , modulates the interaction of PICK1 with GluR6 kainate receptors .
19224535	0	kainate	62,69	GluR6	56,61	kainate	GluR6	MESH:D007608	2898	Chemical	Gene	receptors|amod|START_ENTITY END_ENTITY|dep|receptors	Glutamate receptors on myelinated spinal cord axons : I. GluR6 kainate receptors .
19263192	0	kainate	20,27	GluR6	14,19	kainate	GluR6	MESH:D007608	14806(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of GluR6 kainate receptor subunit in granular layer of weaver mouse cerebellum .
19920140	0	kainate	27,34	GluR6	96,101	kainate	GluR6	MESH:D007608	2898	Chemical	Gene	trafficking|amod|START_ENTITY regulation|nmod|trafficking regulation|nmod|END_ENTITY	Differential regulation of kainate receptor trafficking by phosphorylation of distinct sites on GluR6 .
7536611	0	kainate	107,114	GluR6	78,83	kainate	GluR6	MESH:D007608	2898	Chemical	Gene	subunit|amod|START_ENTITY glutamate|parataxis|subunit glutamate|nsubj|expression expression|nmod|EAA4 EAA4|appos|END_ENTITY	Functional expression and pharmacological characterization of the human EAA4 -LRB- GluR6 -RRB- glutamate receptor : a kainate selective channel subunit .
7659294	0	kainate	108,115	GluR6	102,107	kainate	GluR6	MESH:D007608	2898	Chemical	Gene	subunit|amod|START_ENTITY subunit|amod|END_ENTITY	A role for mossy fiber activation in the loss of CA3 and hilar neurons induced by transduction of the GluR6 kainate receptor subunit .
7675232	0	kainate	46,53	GluR6	40,45	kainate	GluR6	MESH:D007608	2898	Chemical	Gene	START_ENTITY|nsubj|Refinement Refinement|nmod|position position|nmod|END_ENTITY	Refinement of map position of the human GluR6 kainate receptor gene -LRB- GRIK2 -RRB- and lack of association and linkage with idiopathic_generalized_epilepsies .
8034316	0	kainate	12,19	GluR6	6,11	kainate	GluR6	MESH:D007608	2898	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Human GluR6 kainate receptor -LRB- GRIK2 -RRB- : molecular cloning , expression , polymorphism , and chromosomal assignment .
8288598	0	kainate	73,80	GluR6	39,44	kainate	GluR6	MESH:D007608	54257(Tax:10116)	Chemical	Gene	family|amod|START_ENTITY members|nmod|family properties|appos|members properties|nmod|END_ENTITY	Biochemical and assembly properties of GluR6 and KA2 , two members of the kainate receptor family , determined with subunit-specific antibodies .
8382377	0	kainate	36,43	GluR6	54,59	kainate	GluR6	MESH:D007608	2898	Chemical	Gene	receptor|amod|START_ENTITY Phosphorylation|nmod|receptor Phosphorylation|appos|END_ENTITY	Phosphorylation and modulation of a kainate receptor -LRB- GluR6 -RRB- by cAMP-dependent protein kinase .
8392189	0	kainate	135,142	GluR6	114,119	kainate	GluR6	MESH:D007608	2898	Chemical	Gene	receptor|amod|START_ENTITY subunit|nmod|receptor subunit|amod|END_ENTITY	Transsynaptic neuronal loss induced in hippocampal_slice_cultures by a herpes simplex virus vector expressing the GluR6 subunit of the kainate receptor .
8392189	2	kainate	448,455	GluR6	442,447	kainate	GluR6	MESH:D007608	2898	Chemical	Gene	subtype|compound|START_ENTITY subtype|amod|END_ENTITY	Loss of CA3 and hilar neurons was also induced by transducing organotypic hippocampal_slice_cultures with a replication-defective_herpes_simplex_virus -LRB- HSV -RRB- vector expressing the GluR6 kainate subtype of the glutamate receptor -LRB- HSVGluR6 -RRB- .
8618850	0	kainate	28,35	GluR6	22,27	kainate	GluR6	MESH:D007608	2898	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Palmitoylation of the GluR6 kainate receptor .
9108071	0	kainate	23,30	GluR6	17,22	kainate	GluR6	MESH:D007608	2898	Chemical	Gene	locus|amod|START_ENTITY locus|amod|END_ENTITY	Genotypes at the GluR6 kainate receptor locus are associated with variation in the age of onset of Huntington_disease .
15805114	0	kainate	34,41	GluR7	28,33	kainate	GluR7	MESH:D007608	14807(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Differential trafficking of GluR7 kainate receptor subunit splice variants .
16325263	0	kainate	61,68	GluR7	42,47	kainate	GluR7	MESH:D007608	2899	Chemical	Gene	genes|amod|START_ENTITY genes|compound|END_ENTITY	Association study of polymorphisms in the GluR7 , KA1 and KA2 kainate receptor genes -LRB- GRIK3 , GRIK4 , GRIK5 -RRB- with schizophrenia .
16958029	0	kainate	25,32	GluR7	42,47	kainate	GluR7	MESH:D007608	2899	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Association of the human kainate receptor GluR7 gene -LRB- GRIK3 -RRB- with recurrent major_depressive_disorder .
17620617	0	kainate	45,52	GluR7	0,5	kainate	GluR7	MESH:D007608	14807(Tax:10090)	Chemical	Gene	autoreceptors|compound|START_ENTITY subunit|nmod|autoreceptors subunit|nsubj|END_ENTITY	GluR7 is an essential subunit of presynaptic kainate autoreceptors at hippocampal mossy fiber synapses .
7719709	0	kainate	79,86	GluR7	46,51	kainate	GluR7	MESH:D007608	2899	Chemical	Gene	receptor|compound|START_ENTITY characterization|dep|receptor characterization|nmod|receptor receptor|appos|END_ENTITY	Molecular characterization of the human EAA5 -LRB- GluR7 -RRB- receptor : a high-affinity kainate receptor with novel potential RNA editing sites .
9390526	0	kainate	72,79	GluR7	4,9	kainate	GluR7	MESH:D007608	298521(Tax:10116)	Chemical	Gene	subunits|amod|START_ENTITY functional|dobj|subunits functional|nsubj|END_ENTITY	Rat GluR7 and a carboxy-terminal splice variant , GluR7b , are functional kainate receptor subunits with a low sensitivity to glutamate .
9525931	0	kainate	39,46	Glutamate_receptor_6	48,68	kainate	Glutamate receptor 6	MESH:D007608	2898	Chemical	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Sites of volatile anesthetic action on kainate -LRB- Glutamate_receptor_6 -RRB- receptors .
19114596	0	kainate	114,121	KA1	95,98	kainate	KA1	MESH:D007608	110637(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY subunit|nmod|receptor subunit|compound|END_ENTITY	Proteolytic fragments of laminin promote excitotoxic neurodegeneration by up-regulation of the KA1 subunit of the kainate receptor .
8963683	0	kainate	83,90	KA1	110,113	kainate	KA1	MESH:D007608	24406(Tax:10116)	Chemical	Gene	subunits|amod|START_ENTITY subunits|appos|END_ENTITY	Contrasting effects of electroconvulsive shock on mRNAs encoding the high affinity kainate receptor subunits -LRB- KA1 and KA2 -RRB- and cyclophilin in the rat .
12533602	0	kainate	8,15	KA2	89,92	kainate	KA2	MESH:D007608	14809(Tax:10090)	Chemical	Gene	facilitation|amod|START_ENTITY Loss|nmod|facilitation Loss|nmod|END_ENTITY	Loss of kainate receptor-mediated heterosynaptic facilitation of mossy-fiber synapses in KA2 - / - mice .
12878702	0	kainate	38,45	KA2	55,58	kainate	KA2	MESH:D007608	2901	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Multiple trafficking signals regulate kainate receptor KA2 subunit surface expression .
16595684	0	kainate	33,40	KA2	29,32	kainate	KA2	MESH:D007608	2901	Chemical	Gene	receptors|amod|START_ENTITY receptors|nummod|END_ENTITY	Intracellular trafficking of KA2 kainate receptors mediated by interactions with coatomer protein complex I -LRB- COPI -RRB- and 14-3-3 chaperone systems .
8552236	0	kainate	41,48	KA2	66,69	kainate	KA2	MESH:D007608	2901	Chemical	Gene	receptor|compound|START_ENTITY expression|nmod|receptor subunit|nsubj|expression subunit|dobj|END_ENTITY	Synaptic expression of the high-affinity kainate receptor subunit KA2 in hippocampal cultures .
9079693	0	kainate	26,33	KA2	51,54	kainate	KA2	MESH:D007608	24407(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY structure|nmod|receptor subunit|nsubj|structure subunit|dobj|END_ENTITY	Gene structure of the rat kainate receptor subunit KA2 and characterization of an intronic negative regulatory region .
11589992	0	kainate	185,192	caspase_3	165,174	kainate	caspase 3	MESH:D007608	25402(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY administration|amod|END_ENTITY	Heat_shock protein 27 shows a distinctive widespread spatial and temporal pattern of induction in CNS glial and neuronal cells compared to heat_shock protein 70 and caspase_3 following kainate administration .
12533604	0	kainate	77,84	glutamate_receptor_5	56,76	kainate	glutamate receptor 5	MESH:D007608	2897	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Bidirectional modulation of GABA release by presynaptic glutamate_receptor_5 kainate receptors in the basolateral amygdala .
12151522	0	kainate	19,26	glutamate_receptor_6	44,64	kainate	glutamate receptor 6	MESH:D007608	14806(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY Recruitment|nmod|receptor subunit|nsubj|Recruitment subunit|dobj|END_ENTITY	Recruitment of the kainate receptor subunit glutamate_receptor_6 by cadherin/catenin complexes .
15193534	0	kainate	57,64	neurofilament_light	15,34	kainate	neurofilament light	MESH:D007608	83613(Tax:10116)	Chemical	Gene	Alterations|nmod|START_ENTITY Alterations|nmod|END_ENTITY	Alterations in neurofilament_light in optic_nerve in rat kainate and monkey ocular_hypertension models .
10978588	0	kainic_acid	61,72	Aryl_hydrocarbon_receptor_nuclear_translocator	0,46	kainic acid	Aryl hydrocarbon receptor nuclear translocator	MESH:D007608	25242(Tax:10116)	Chemical	Gene	cells|amod|START_ENTITY induced|nmod|cells induced|nsubjpass|END_ENTITY	Aryl_hydrocarbon_receptor_nuclear_translocator is induced by kainic_acid in rat hippocampal glial cells .
10686075	0	kainic_acid	42,53	CA3	63,66	kainic acid	CA3	MESH:D007608	54232(Tax:10116)	Chemical	Gene	region|amod|START_ENTITY region|compound|END_ENTITY	Survival of grafted fetal neural cells in kainic_acid lesioned CA3 region of adult hippocampus depends upon cell specificity .
12803974	0	kainic_acid	53,64	CA3	22,25	kainic acid	CA3	MESH:D007608	54232(Tax:10116)	Chemical	Gene	vulnerability|nmod|START_ENTITY vulnerability|compound|END_ENTITY	Increased hippocampal CA3 vulnerability to low-level kainic_acid following lateral fluid percussion injury .
12902026	0	kainic_acid	202,213	CA3	153,156	kainic acid	CA3	MESH:D007608	12350(Tax:10090)	Chemical	Gene	intracerebroventricularly|amod|START_ENTITY administered|nmod|intracerebroventricularly Role|acl|administered Role|nmod|region region|compound|END_ENTITY	Role of glutamate receptors and an on-going protein synthesis in the regulation of phosphorylation of Ca2 + / calmodulin-dependent_protein_kinase_II in the CA3 hippocampal region in mice administered with kainic_acid intracerebroventricularly .
24288771	0	kainic_acid	83,94	CA3	68,71	kainic acid	CA3	MESH:D007608	54232(Tax:10116)	Chemical	Gene	field|nmod|START_ENTITY field|compound|END_ENTITY	Memory_disorders in rats after impairment of the dorsal hippocampal CA3 field with kainic_acid .
24704461	0	kainic_acid	150,161	CA3	85,88	kainic acid	CA3	MESH:D007608	12350(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY death|acl|induced death|compound|END_ENTITY	Effects of nateglinide and repaglinide administered intracerebroventricularly on the CA3 hippocampal neuronal cell death and hyperglycemia induced by kainic_acid in mice .
24713348	0	kainic_acid	142,153	CA3	77,80	kainic acid	CA3	MESH:D007608	12350(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY death|acl|induced death|nummod|END_ENTITY	Effect of tolbutamide , glyburide and glipizide administered supraspinally on CA3 hippocampal neuronal cell death and hyperglycemia induced by kainic_acid in mice .
25218563	0	kainic_acid	144,155	CA3	69,72	kainic acid	CA3	MESH:D007608	12350(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Effect Effect|acl|administered administered|nmod|death death|nummod|END_ENTITY	Effect of pertussis and cholera_toxins administered supraspinally on CA3 hippocampal neuronal cell death and the blood glucose level induced by kainic_acid in mice .
2908124	0	kainic_acid	96,107	CA3	60,63	kainic acid	CA3	MESH:D007608	54232(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|modification modification|nmod|properties properties|nmod|neurones neurones|compound|END_ENTITY	Long-lasting modification of the synaptic properties of rat CA3 hippocampal neurones induced by kainic_acid .
3359218	0	kainic_acid	48,59	CA3	73,76	kainic acid	CA3	MESH:D007608	54232(Tax:10116)	Chemical	Gene	provoke|nsubj|START_ENTITY provoke|dobj|bursting bursting|nummod|END_ENTITY	Mossy fiber lesion reduces the probability that kainic_acid will provoke CA3 hippocampal pyramidal cell bursting .
7127132	0	kainic_acid	55,66	CA3	77,80	kainic acid	CA3	MESH:D007608	54232(Tax:10116)	Chemical	Gene	lesion|amod|START_ENTITY Localization|nmod|lesion Localization|nmod|END_ENTITY	Localization of hippocampal muscarinic receptors after kainic_acid lesion of CA3 and fimbria-fornix transection .
7260619	0	kainic_acid	72,83	CA3	47,50	kainic acid	CA3	MESH:D007608	761	Chemical	Gene	hippocampal|nmod|START_ENTITY hippocampal|dobj|cells cells|nummod|END_ENTITY	Spatial memory following damage to hippocampal CA3 pyramidal cells with kainic_acid : impairment and recovery with preoperative training .
7316692	0	kainic_acid	29,40	CA3	53,56	kainic acid	CA3	MESH:D007608	54232(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of small doses of kainic_acid on the area CA3 of the hippocampal formation .
7400401	0	kainic_acid	76,87	CA3	28,31	kainic acid	CA3	MESH:D007608	761	Chemical	Gene	START_ENTITY|nsubj|Degeneration Degeneration|nmod|cells cells|compound|END_ENTITY	Degeneration of hippocampal CA3 pyramidal cells induced by intraventricular kainic_acid .
9685600	0	kainic_acid	186,197	CA3	70,73	kainic acid	CA3	MESH:D007608	54232(Tax:10116)	Chemical	Gene	treated|nmod|START_ENTITY Changes|acl|treated Changes|nmod|END_ENTITY	Changes in extracellular glutamate and GABA levels in the hippocampal CA3 and CA1 areas and the induction of glutamic_acid decarboxylase-67 in dentate granule cells of rats treated with kainic_acid .
9472398	0	kainic_acid	33,44	Fos	0,3	kainic acid	Fos	MESH:D007608	490792(Tax:9615)	Chemical	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	Fos induction following systemic kainic_acid : early expression in hippocampus and later widespread expression correlated with seizure .
8491045	0	kainic_acid	53,64	Ornithine_decarboxylase	0,23	kainic acid	Ornithine decarboxylase	MESH:D007608	24609(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Ornithine_decarboxylase is differentially induced by kainic_acid during brain development in the rat .
16888156	0	kainic_acid	66,77	PACAP	31,36	kainic acid	PACAP	MESH:D007608	116	Chemical	Gene	effects|nmod|START_ENTITY blocks|dobj|effects blocks|nsubj|END_ENTITY	Microiontophoretically applied PACAP blocks excitatory effects of kainic_acid in vivo .
6641886	0	kainic_acid	36,47	Prolactin	0,9	kainic acid	Prolactin	MESH:D007608	24683(Tax:10116)	Chemical	Gene	administration|amod|START_ENTITY induced|nmod|administration release|dep|induced release|nsubj|END_ENTITY	Prolactin and LH release induced by kainic_acid administration within the preoptic-suprachiasmatic region in behaving male rats .
11814629	0	kainic_acid	24,35	alpha-MSH	11,20	kainic acid	alpha-MSH	MESH:D007608	24664(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of alpha-MSH on kainic_acid induced changes in core temperature in rats .
10479679	0	kainic_acid	174,185	brain-derived_neurotrophic_factor	27,60	kainic acid	brain-derived neurotrophic factor	MESH:D007608	24225(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY 5|dep|regulation expression|dep|5 expression|acl|END_ENTITY	Differential expression of brain-derived_neurotrophic_factor , neurotrophin-3 , and neurotrophin-4 / 5 in the adult rat spinal cord : regulation by the glutamate receptor agonist kainic_acid .
10521588	0	kainic_acid	76,87	brain-derived_neurotrophic_factor	23,56	kainic acid	brain-derived neurotrophic factor	MESH:D007608	24225(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Negative regulation of brain-derived_neurotrophic_factor mRNA expression by kainic_acid in substantia nigra .
1641125	0	kainic_acid	171,182	brain-derived_neurotrophic_factor	43,76	kainic acid	brain-derived neurotrophic factor	MESH:D007608	24225(Tax:10116)	Chemical	Gene	administration|nmod|START_ENTITY induced|nmod|administration seizures|acl|induced brain|nmod|seizures RNA|nmod|brain increases|nsubj|RNA increases|nmod|messenger messenger|amod|END_ENTITY	Regionally specific and rapid increases in brain-derived_neurotrophic_factor messenger RNA in the adult rat brain following seizures induced by systemic administration of kainic_acid .
18445478	0	kainic_acid	46,57	brain-derived_neurotrophic_factor	67,100	kainic acid	brain-derived neurotrophic factor	MESH:D007608	627	Chemical	Gene	kinase|nmod|START_ENTITY Activation|nmod|kinase mediates|nsubj|Activation mediates|dobj|expression expression|amod|END_ENTITY	Activation of AMP-activated protein kinase by kainic_acid mediates brain-derived_neurotrophic_factor expression through a NF-kappaB dependent mechanism in C6 glioma cells .
9692712	0	kainic_acid	139,150	brain-derived_neurotrophic_factor	33,66	kainic acid	brain-derived neurotrophic factor	MESH:D007608	12064(Tax:10090)	Chemical	Gene	injection|amod|START_ENTITY hippocampus|nmod|injection hippocampus|nsubj|increase increase|nmod|proteins proteins|compound|END_ENTITY	Correlated long-term increase of brain-derived_neurotrophic_factor and Trk_B proteins in enlarged granule cells of mouse hippocampus after kainic_acid injection .
12900917	0	kainic_acid	72,83	caspase-3	47,56	kainic acid	caspase-3	MESH:D007608	25402(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|distribution distribution|nmod|END_ENTITY	Temporal and spatial distribution of activated caspase-3 after subdural kainic_acid infusions in rat spinal cord .
20635438	0	kainic_acid	68,79	cathepsin_E	34,45	kainic acid	cathepsin E	MESH:D007608	25424(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY expression|acl|induced expression|amod|END_ENTITY	The ketogenic diet suppresses the cathepsin_E expression induced by kainic_acid in the rat brain .
8809832	1	kainic_acid	82,93	fos-related_antigen	43,62	kainic acid	fos-related antigen	MESH:D007608	80754(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY END_ENTITY|nmod|treatment	wt fos-related_antigen in rat brain after kainic_acid treatment .
21418984	0	kainic_acid	55,66	ghrelin	29,36	kainic acid	ghrelin	MESH:D007608	59301(Tax:10116)	Chemical	Gene	rats|amod|START_ENTITY END_ENTITY|nmod|rats	-LSB- Expression of neuropeptides ghrelin and Nesfatin-1 in kainic_acid kindling rats -RSB- .
10740232	0	kainic_acid	169,180	interleukin-1beta	38,55	kainic acid	interleukin-1beta	MESH:D007608	24494(Tax:10116)	Chemical	Gene	administration|amod|START_ENTITY expression|nmod|administration expression|amod|END_ENTITY	Increased expression of mRNA encoding interleukin-1beta and caspase-1 , and the secreted isoform of interleukin-1 receptor antagonist in the rat brain following systemic kainic_acid administration .
1407701	0	kainic_acid	93,104	ornithine_decarboxylase	19,42	kainic acid	ornithine decarboxylase	MESH:D007608	4953	Chemical	Gene	administration|nmod|START_ENTITY END_ENTITY|nmod|administration	Induction of brain ornithine_decarboxylase after systemic or intrastriatal administration of kainic_acid .
21551719	0	kainic_acid	88,99	ornithine_decarboxylase	135,158	kainic acid	ornithine decarboxylase	MESH:D007608	4953	Chemical	Gene	neuropathology|amod|START_ENTITY neuropathology|dep|evaluation evaluation|nmod|induction induction|amod|END_ENTITY	Pharmacological manipulation of the NMDA receptor differentially protects from systemic kainic_acid neuropathology : evaluation through ornithine_decarboxylase induction , morphology and GFAP immunohistochemistry .
9519284	0	kainic_acid	92,103	proenkephalin	34,47	kainic acid	proenkephalin	MESH:D007608	29237(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY expression|acl|induced expression|compound|END_ENTITY	Phenidone blocks the increases of proenkephalin and prodynorphin gene expression induced by kainic_acid in rat hippocampus : involvement of Fos-related antigene protein .
8943780	0	kainic_acid	35,46	prolactin	50,59	kainic acid	prolactin	MESH:D007608	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Mechanisms of inhibitory action of kainic_acid on prolactin secretion in male rats .
9578517	0	kainic_acid	40,51	prolactin	55,64	kainic acid	prolactin	MESH:D007608	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Effects of N-methyl-D-aspartic_acid and kainic_acid on prolactin secretion in hyper - _ and_hypoprolactinaemic_conditions .
8032609	8	kallidin	972,980	bradykinin	959,969	kallidin	bradykinin	MESH:D007609	3827	Chemical	Gene	des-Arg9-bradykinin|compound|START_ENTITY des-Arg9-bradykinin|compound|END_ENTITY	In both healthy and squamous-carcinoma preparations , bradykinin analogues displace -LSB- 3H -RSB- - bradykinin binding with the following relative order of potency : Hoe_140 > bradykinin > kallidin > D-Arg0 -LSB- Hyp3,D-Phe7 -RSB- bradykinin > des-Arg9-bradykinin .
1334488	0	kallikrein	34,44	Kallistatin	0,11	kallikrein	Kallistatin	MESH:D007610	5267	Chemical	Gene	inhibitor|compound|START_ENTITY END_ENTITY|dep|inhibitor	Kallistatin : a novel human tissue kallikrein inhibitor .
17605824	0	kallikrein	54,64	MMP-2	30,35	kallikrein	MMP-2	MESH:D007610	100719361	Chemical	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Spatio-temporal expression of MMP-2 , MMP-9 and tissue kallikrein in uteroplacental units of the pregnant guinea-pig -LRB- Cavia_porcellus -RRB- .
1309555	0	kallikrein	159,169	RSKG-7	90,96	kallikrein	RSKG-7	MESH:D007610	24523(Tax:10116)	Chemical	Gene	family|compound|START_ENTITY proteases|nmod|family relation|nmod|proteases gland|nmod|relation gland|dep|homologous homologous|nmod|gene gene|compound|END_ENTITY	Immunohistochemical localization of rat submandibular gland esterase_B -LRB- homologous to the RSKG-7 kallikrein gene -RRB- in relation to other serine proteases of the kallikrein family .
1309555	0	kallikrein	97,107	RSKG-7	90,96	kallikrein	RSKG-7	MESH:D007610	24523(Tax:10116)	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Immunohistochemical localization of rat submandibular gland esterase_B -LRB- homologous to the RSKG-7 kallikrein gene -RRB- in relation to other serine proteases of the kallikrein family .
1385031	0	kallikrein	57,67	angiotensin_II	14,28	kallikrein	angiotensin II	MESH:D007610	183	Chemical	Gene	Generation|nmod|START_ENTITY Generation|nmod|END_ENTITY	Generation of angiotensin_II from human plasma by tissue kallikrein .
7692967	0	kallikrein	160,170	antithrombin	103,115	kallikrein	antithrombin	MESH:D007610	462	Chemical	Gene	regulation|nmod|START_ENTITY antithrombin|nmod|regulation role|nmod|antithrombin END_ENTITY|dep|role	High_molecular_weight_kininogen potentiates the heparin-accelerated inhibition of plasma kallikrein by antithrombin : role for antithrombin in the regulation of kallikrein .
7692967	0	kallikrein	160,170	antithrombin	126,138	kallikrein	antithrombin	MESH:D007610	462	Chemical	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	High_molecular_weight_kininogen potentiates the heparin-accelerated inhibition of plasma kallikrein by antithrombin : role for antithrombin in the regulation of kallikrein .
7692967	0	kallikrein	89,99	antithrombin	103,115	kallikrein	antithrombin	MESH:D007610	462	Chemical	Gene	inhibition|nmod|START_ENTITY potentiates|dobj|inhibition potentiates|nmod|END_ENTITY	High_molecular_weight_kininogen potentiates the heparin-accelerated inhibition of plasma kallikrein by antithrombin : role for antithrombin in the regulation of kallikrein .
7692967	0	kallikrein	89,99	antithrombin	126,138	kallikrein	antithrombin	MESH:D007610	462	Chemical	Gene	inhibition|nmod|START_ENTITY potentiates|dobj|inhibition potentiates|nmod|antithrombin antithrombin|dep|role role|nmod|END_ENTITY	High_molecular_weight_kininogen potentiates the heparin-accelerated inhibition of plasma kallikrein by antithrombin : role for antithrombin in the regulation of kallikrein .
2531092	0	kallikrein	49,59	atrial_natriuretic_peptide	11,37	kallikrein	atrial natriuretic peptide	MESH:D007610	24602(Tax:10116)	Chemical	Gene	excretion|compound|START_ENTITY Effects|nmod|excretion Effects|nmod|END_ENTITY	Effects of atrial_natriuretic_peptide on urinary kallikrein excretion and renal function in rats .
8206938	0	kallikrein	115,125	high_molecular_weight_kininogen	73,104	kallikrein	high molecular weight kininogen	MESH:D007610	3827	Chemical	Gene	alterations|nmod|START_ENTITY alterations|nmod|END_ENTITY	Surface-induced alterations in the kinetic pathway for cleavage of human high_molecular_weight_kininogen by plasma kallikrein .
10839777	0	kallikrein	72,82	prostate-specific_antigen	18,43	kallikrein	prostate-specific antigen	MESH:D007610	354	Chemical	Gene	concentrations|compound|START_ENTITY concentrations|amod|END_ENTITY	Serum and urinary prostate-specific_antigen and urinary human glandular kallikrein concentrations are significantly increased after testosterone administration in female-to-male transsexuals .
1334618	0	kallikrein	21,31	protein_C_inhibitor	53,72	kallikrein	protein C inhibitor	MESH:D007610	5104	Chemical	Gene	protein|compound|START_ENTITY protein|nmod|END_ENTITY	Possible identity of kallikrein binding protein with protein_C_inhibitor .
2425102	0	kallikrein	18,28	renin	65,70	kallikrein	renin	MESH:D007610	5972	Chemical	Gene	role|nmod|START_ENTITY role|nmod|control control|nmod|release release|compound|END_ENTITY	The role of renal kallikrein and prostaglandin in the control of renin release .
6187220	0	kallikrein	14,24	renin	39,44	kallikrein	renin	MESH:D007610	24715(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|control control|nmod|END_ENTITY	Role of renal kallikrein in control of renin release in conscious rats .
6190639	0	kallikrein	39,49	renin	53,58	kallikrein	renin	MESH:D007610	24715(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	Reexamination of the effect of urinary kallikrein on renin release : evidence that kallikrein does not release renin but protects renin from destruction .
6190639	0	kallikrein	82,92	renin	110,115	kallikrein	renin	MESH:D007610	24715(Tax:10116)	Chemical	Gene	release|nsubj|START_ENTITY release|dobj|END_ENTITY	Reexamination of the effect of urinary kallikrein on renin release : evidence that kallikrein does not release renin but protects renin from destruction .
3081506	0	kallikrein	42,52	thrombin	77,85	kallikrein	thrombin	MESH:D007610	2147	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	The activation of pro-urokinase by plasma kallikrein and its inactivation by thrombin .
25472767	0	kanglaite	10,19	cytochrome_P450	27,42	kanglaite	cytochrome P450	MESH:C499781	25251(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of kanglaite on rat cytochrome_P450 .
10234031	0	kappaB	15,21	c-Myc	56,61	kappaB	c-Myc	null	24577(Tax:10116)	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Nuclear factor kappaB nuclear translocation upregulates c-Myc and p53 expression during NMDA receptor-mediated apoptosis in rat striatum .
6178381	0	kassinin	74,82	Growth_hormone	0,14	kassinin	Growth hormone	MESH:D015286	81668(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|END_ENTITY	Growth_hormone , prolactin and FSH release by the tachykinin dodecapeptide kassinin in the rat .
12536733	0	katamine	12,20	interleukin-6	55,68	katamine	interleukin-6	null	3569	Chemical	Gene	START_ENTITY|nmod|response response|amod|END_ENTITY	-LSB- Effects of katamine on cardiopulmonary bypass-induced interleukin-6 and interleukin-8 response and its significance -RSB- .
20463617	0	katanin-P60	14,25	LECT2	36,41	katanin-P60	LECT2	null	16841(Tax:10090)	Chemical	Gene	levels|amod|START_ENTITY levels|nmod|END_ENTITY	Regulation of katanin-P60 levels by LECT2 adjusts microtubular morphology .
17062944	0	katemine	23,31	nNOS	53,57	katemine	nNOS	null	24598(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of intrathecal katemine on the expression of nNOS in spinal dorsal horn in rats with formalin pain -RSB- .
17059169	0	kaurane_diterpenes	29,47	PTP1B	0,5	kaurane diterpenes	PTP1B	MESH:D045786	5770	Chemical	Gene	activity|nmod|START_ENTITY activity|nummod|END_ENTITY	PTP1B inhibitory activity of kaurane_diterpenes isolated from Siegesbeckia glabrescens .
24152993	0	keratan_sulfate	62,77	KSGal6ST	0,8	keratan sulfate	KSGal6ST	MESH:D007632	8534	Chemical	Gene	essential|nmod|START_ENTITY essential|nsubj|END_ENTITY	KSGal6ST is essential for the 6-sulfation of galactose within keratan_sulfate in early postnatal brain .
24839168	0	ketamine	135,143	BDNF	119,123	ketamine	BDNF	MESH:D007649	24225(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	MicroRNA expression profile and functional analysis reveal that miR-206 is a critical novel gene for the expression of BDNF induced by ketamine .
26275358	0	ketamine	126,134	BDNF	6,10	ketamine	BDNF	MESH:D007649	627	Chemical	Gene	comparison|nmod|START_ENTITY END_ENTITY|dep|comparison	Serum BDNF as a peripheral biomarker of treatment-resistant_depression and the rapid antidepressant response : A comparison of ketamine and ECT .
3073290	0	ketamine	98,106	CO2	48,51	ketamine	CO2	MESH:D007649	717	Chemical	Gene	Lack|nmod|START_ENTITY Lack|nmod|END_ENTITY	-LSB- Lack of depression of ventilatory responses to CO2 following epidural or intravenous infusion of ketamine in postoperative analgesia after upper abdominal surgery -RSB- .
11353758	0	ketamine	44,52	CYP2B6	15,21	ketamine	CYP2B6	MESH:D007649	1555	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of CYP2B6 in n-demethylation of ketamine in human liver microsomes .
19826911	0	ketamine	10,18	ERK	22,25	ketamine	ERK	MESH:D007649	24338(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of ketamine on ERK expression in hippocampal neural cell and the ability of learning behavior in minor rats .
15291108	0	ketamine	32,40	HSP70	15,20	ketamine	HSP70	MESH:D007649	266759(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Expression Expression|nmod|END_ENTITY	-LSB- Expression of HSP70 induced by ketamine in the hippocampus of rat at different ages -RSB- .
8635538	0	ketamine	21,29	HSP70	57,62	ketamine	HSP70	MESH:D007649	266759(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Haloperidol prevents ketamine - and phencyclidine-induced HSP70 protein expression but not microglial activation .
17922067	0	ketamine	11,19	TLR4	33,37	ketamine	TLR4	MESH:D007649	29260(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of ketamine on pulmonary TLR4 expression and NF-kappa-B activation during endotoxemia in rats .
11496686	0	ketamine	64,72	TNF-alpha	35,44	ketamine	TNF-alpha	MESH:D007649	7124	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Modulation of endotoxin-stimulated TNF-alpha gene expression by ketamine and propofol in cultured human whole blood .
8469433	0	ketamine	10,18	c-Fos	35,40	ketamine	c-Fos	MESH:D007649	314322(Tax:10116)	Chemical	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|amod|END_ENTITY	High-dose ketamine does not induce c-Fos protein expression in rat hippocampus .
18362774	0	ketamine	74,82	c-Jun	18,23	ketamine	c-Jun	MESH:D007649	3725	Chemical	Gene	effects|nmod|START_ENTITY expression|dep|effects expression|amod|END_ENTITY	Glutamate-induced c-Jun expression in neuronal PC12 cells : the effects of ketamine and propofol .
15281522	0	ketamine	33,41	c-fos	122,127	ketamine	c-fos	MESH:D007649	314322(Tax:10116)	Chemical	Gene	pretreatment|nmod|START_ENTITY prevent|nsubj|pretreatment prevent|dobj|arthritic_pain arthritic_pain|dep|relevance relevance|nmod|decrease decrease|nmod|expression expression|amod|END_ENTITY	Intraarticular pretreatment with ketamine and memantine could prevent arthritic_pain : relevance to the decrease of spinal c-fos expression in rats .
24308186	0	ketamine	166,174	c-fos	94,99	ketamine	c-fos	MESH:D007649	314322(Tax:10116)	Chemical	Gene	rats|amod|START_ENTITY Effect|nmod|rats Effect|nmod|END_ENTITY	-LSB- Effect of electroacupuncture intervention at different time-points in a day on expression of c-fos and neuronal nitric_oxide synthase in medial prefrontal cortex in ketamine addiction rats -RSB- .
24415690	0	ketamine	12,20	c-fos	57,62	ketamine	c-fos	MESH:D007649	493935(Tax:9685)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|amod|END_ENTITY	-LSB- Effects of ketamine and urethane on stimulation-induced c-fos expression in neurons of cat visual cortex -RSB- .
2437471	0	ketamine	11,19	cholecystokinin	27,42	ketamine	cholecystokinin	MESH:D007649	25298(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of ketamine on the cholecystokinin , somatostatin , substance P , and thyrotropin_releasing_hormone in discrete regions of rat brain .
23062356	0	ketamine	84,92	eukaryotic_elongation_factor_2_kinase	12,49	ketamine	eukaryotic elongation factor 2 kinase	MESH:D007649	29904	Chemical	Gene	action|nmod|START_ENTITY role|nmod|action role|nmod|END_ENTITY	The role of eukaryotic_elongation_factor_2_kinase in rapid antidepressant action of ketamine .
18390394	0	ketamine	93,101	glutathione_S-transferase	21,46	ketamine	glutathione S-transferase	MESH:D007649	58962(Tax:10116)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of hepatic glutathione_S-transferase and UDP-glucuronosyltransferase activities by ketamine in rats .
24914689	0	ketamine	10,18	miR-214	106,113	ketamine	miR-214	MESH:D007649	100314055(Tax:10116)	Chemical	Gene	Impact|nmod|START_ENTITY Impact|nmod|END_ENTITY	Impact of ketamine on learning and memory function , neuronal apoptosis and its potential association with miR-214 and PTEN in adolescent rats .
26905413	0	ketamine	66,74	p11	20,23	ketamine	p11	MESH:D007649	81778(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY Role|nmod|effect Role|nmod|END_ENTITY	Role of hippocampal p11 in the sustained antidepressant effect of ketamine in the chronic_unpredictable_mild_stress model .
1820453	0	ketamine	13,21	renin	48,53	ketamine	renin	MESH:D007649	100358545(Tax:9986)	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Influence of ketamine and propranolol on plasma renin activity -LRB- PRA -RRB- in female rabbits and guinea_pigs .
23880871	0	ketamine	23,31	serotonin_transporter	53,74	ketamine	serotonin transporter	MESH:D007649	6532	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Subanesthetic doses of ketamine transiently decrease serotonin_transporter activity : a PET study in conscious monkeys .
11212871	0	ketamine_hydrochloride	14,36	prolactin	99,108	ketamine hydrochloride	prolactin	MESH:D007649	707052(Tax:9544)	Chemical	Gene	anesthesia|amod|START_ENTITY anesthesia|nmod|END_ENTITY	The effect of ketamine_hydrochloride anesthesia on basal and N-methyl-D , L-aspartate induced plasma prolactin secretion in the adult male rhesus_monkey .
2931964	0	ketanserin	14,24	5-HT2-receptor	28,42	ketanserin	5-HT2-receptor	MESH:D007650	3356	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	The effect of ketanserin , a 5-HT2-receptor antagonist , on 5-hydroxytryptamine-induced irreversible platelet_aggregation in patients with cardiovascular_diseases .
2932476	0	ketanserin	11,21	5-HT2-receptor	25,39	ketanserin	5-HT2-receptor	MESH:D007650	3356	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Effects of ketanserin , a 5-HT2-receptor antagonist , on the blood flow response to temperature changes in the diabetic foot .
6140126	0	ketanserin	13,23	5-HT2-receptor	65,79	ketanserin	5-HT2-receptor	MESH:D007650	3356	Chemical	Gene	Influence|nmod|START_ENTITY Influence|appos|agent agent|nmod|END_ENTITY	Influence of ketanserin , an antihypertensive agent with specific 5-HT2-receptor blocking activity , on intracranial_pressure .
6215842	0	ketanserin	87,97	5-HT2-receptor	122,136	ketanserin	5-HT2-receptor	MESH:D007650	3356	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Inhibition of 5-hydroxytryptamine-induced and - amplified human platelet_aggregation by ketanserin -LRB- R_41_468 -RRB- , a selective 5-HT2-receptor antagonist .
6486973	0	ketanserin	79,89	5-HT2-receptor	103,117	ketanserin	5-HT2-receptor	MESH:D007650	3356	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Restoration of post-thrombotic peripheral collateral circulation in the cat by ketanserin , a selective 5-HT2-receptor antagonist .
2180341	0	ketanserin	10,20	5-HT2_receptor	50,64	ketanserin	5-HT2 receptor	MESH:D007650	3356	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|new new|acl|blocking blocking|dobj|agent agent|nmod|END_ENTITY	Effect of ketanserin , a new blocking agent of the 5-HT2_receptor , on airway responsiveness in asthma .
2412069	0	ketanserin	103,113	5-HT2_receptor	117,131	ketanserin	5-HT2 receptor	MESH:D007650	3356	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Comparison of blood pressure ratio by Doppler velocimetry and by plethysmography during treatment with ketanserin , a 5-HT2_receptor antagonist : a measure of improved collateral and microcirculatory flow .
3567710	0	ketanserin	40,50	5-HT2_receptor	54,68	ketanserin	5-HT2 receptor	MESH:D007650	3356	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|antagonist antagonist|amod|END_ENTITY	Hemodynamic and neurohumoral effects of ketanserin , a 5-HT2_receptor antagonist in patients with congestive_heart_failure .
6196551	0	ketanserin	71,81	5-HT2_receptor	45,59	ketanserin	5-HT2 receptor	MESH:D007650	3356	Chemical	Gene	START_ENTITY|nsubj|Pharmacokinetics Pharmacokinetics|nmod|antagonist antagonist|amod|END_ENTITY	Pharmacokinetics and pharmacodynamics of the 5-HT2_receptor antagonist ketanserin in man .
6800533	0	ketanserin	31,41	5-HT2_receptor	59,73	ketanserin	5-HT2 receptor	MESH:D007650	3356	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Treatment of hypertension with ketanserin , a new selective 5-HT2_receptor antagonist .
7271395	0	ketanserin	21,31	5-HT2_receptor	56,70	ketanserin	5-HT2 receptor	MESH:D007650	3356	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Vascular activity of ketanserin -LRB- R_41_468 -RRB- , a selective 5-HT2_receptor antagonist .
6188804	0	ketanserin	35,45	CSF	101,104	ketanserin	CSF	MESH:D007650	1437	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	The 5-hydroxytryptamine antagonist ketanserin inhibits the vasoconstrictor activity of per-operative CSF , from subarachnoid_haemorrhage patients , on isolated tissues .
2140838	0	ketanserin	11,21	atrial_natriuretic_factor	58,83	ketanserin	atrial natriuretic factor	MESH:D007650	4878	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of ketanserin on lipids , lipoproteins , and plasma atrial_natriuretic_factor in patients with essential hypertension .
6751979	0	ketanserin	10,20	renin	68,73	ketanserin	renin	MESH:D007650	5972	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|compound|END_ENTITY	Effect of ketanserin , a new inhibitor of 5-HT2 receptors , on plasma renin activity and aldosterone levels in normal subject .
23314864	0	ketimine	61,69	glutamate_dehydrogenase	34,57	ketimine	glutamate dehydrogenase	MESH:C542835	2746	Chemical	Gene	comparison|acl|START_ENTITY comparison|nmod|END_ENTITY	Imine reductases : a comparison of glutamate_dehydrogenase to ketimine reductases in the brain .
24102193	0	keto-benzimidazoles	57,76	phosphodiesterase_10A	115,136	keto-benzimidazoles	phosphodiesterase 10A	null	63885(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Design , optimization , and biological evaluation of novel keto-benzimidazoles as potent and selective inhibitors of phosphodiesterase_10A -LRB- PDE10A -RRB- .
2805821	0	keto_acid	74,83	BCKDHA	99,105	keto acid	BCKDHA	null	593	Chemical	Gene	START_ENTITY|dobj|dehydrogenase dehydrogenase|appos|END_ENTITY	Localization of the human gene for the El alpha subunit of branched chain keto_acid dehydrogenase -LRB- BCKDHA -RRB- to chromosome 19q13 .1 -- q13 .2 .
2004553	0	keto_acid	104,113	dihydrolipoamide_branched-chain_transacylase_gene	20,69	keto acid	dihydrolipoamide branched-chain transacylase gene	null	1629	Chemical	Gene	START_ENTITY|nsubj|Localization Localization|nmod|END_ENTITY	Localization of the dihydrolipoamide_branched-chain_transacylase_gene -LRB- DBT -RRB- of the human branched-chain keto_acid dehydrogenase complex to chromosome 1 .
19962796	0	ketoamides	19,29	cathepsin_K	39,50	ketoamides	cathepsin K	null	1513	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	3D QSAR studies on ketoamides of human cathepsin_K inhibitors based on two different alignment methods .
1659100	0	ketoconazole	35,47	ACTH	51,55	ketoconazole	ACTH	MESH:D007654	5443	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	In vivo and in vitro inhibition by ketoconazole of ACTH secretion from a human thymic_carcinoid_tumour .
2832292	0	ketoconazole	87,99	ACTH	0,4	ketoconazole	ACTH	MESH:D007654	5443	Chemical	Gene	corticotropin_releasing_hormone|nmod|START_ENTITY END_ENTITY|advcl|corticotropin_releasing_hormone	ACTH response to corticotropin_releasing_hormone in Cushing 's _ disease before and after ketoconazole : in vivo and in vitro studies .
24692738	0	ketoconazole	31,43	Bcl-2	157,162	ketoconazole	Bcl-2	MESH:D007654	596	Chemical	Gene	co-administration|nmod|START_ENTITY Effect|nmod|co-administration Effect|appos|inhibitor inhibitor|compound|END_ENTITY	Effect of co-administration of ketoconazole , a strong CYP3A inhibitor , on the pharmacokinetics , safety and tolerability of navitoclax , a first-in-class oral Bcl-2 family inhibitor , in cancer patients .
10745059	0	ketoconazole	57,69	CYP3A	36,41	ketoconazole	CYP3A	MESH:D007654	1576	Chemical	Gene	inhibitors|amod|START_ENTITY inhibition|nmod|inhibitors inhibition|nmod|metabolism metabolism|nmod|trazodone trazodone|nmod|END_ENTITY	In vitro metabolism of trazodone by CYP3A : inhibition by ketoconazole and human immunodeficiency viral protease inhibitors .
10952482	0	ketoconazole	103,115	CYP3A	43,48	ketoconazole	CYP3A	MESH:D007654	1576	Chemical	Gene	comparison|nmod|START_ENTITY inhibition|dep|comparison inhibition|nmod|END_ENTITY	Potent mechanism-based inhibition of human CYP3A in vitro by amprenavir and ritonavir : comparison with ketoconazole .
16673044	6	ketoconazole	1229,1241	CYP3A	1268,1273	ketoconazole	CYP3A	MESH:D007654	170509(Tax:10116)	Chemical	Gene	START_ENTITY|appos|specific specific|nmod|reactions reactions|nummod|END_ENTITY	Similarities in the inhibition of the constitutive and inducible brain and liver EMD activity following in vitro addition of ketoconazole , a inhibitor specific for CYP3A catalysed reactions and anti-CYP3A have further indicated that like in liver , CYP3A isoenzymes catalyse the activity of EMD in rat brain .
16997909	0	ketoconazole	39,51	CYP3A	99,104	ketoconazole	CYP3A	MESH:D007654	1576	Chemical	Gene	inhibition|nmod|START_ENTITY reduce|nsubj|inhibition reduce|dobj|variability variability|nmod|activity activity|nummod|END_ENTITY	Drug-metabolizing enzyme inhibition by ketoconazole does not reduce interindividual variability of CYP3A activity as measured by oral midazolam .
19246732	0	ketoconazole	77,89	CYP3A	57,62	ketoconazole	CYP3A	MESH:D007654	1576	Chemical	Gene	substrates|nmod|START_ENTITY substrates|nummod|END_ENTITY	Quantitative evaluation of pharmacokinetic inhibition of CYP3A substrates by ketoconazole : a simulation study .
19246734	0	ketoconazole	38,50	CYP3A	83,88	ketoconazole	CYP3A	MESH:D007654	1576	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|nmod|substrate substrate|compound|END_ENTITY	The need for multiple doses of 400 mg ketoconazole as a precipitant inhibitor of a CYP3A substrate in an in vivo drug-drug interaction study .
19740395	0	ketoconazole	74,86	CYP3A	54,59	ketoconazole	CYP3A	MESH:D007654	1576	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|effect effect|nmod|pharmacokinetics pharmacokinetics|nmod|END_ENTITY	The effect on sotrastaurin pharmacokinetics of strong CYP3A inhibition by ketoconazole .
19801894	0	ketoconazole	22,34	CYP3A	75,80	ketoconazole	CYP3A	MESH:D007654	1576	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activities activities|compound|END_ENTITY	Inhibitory effects of ketoconazole , cimetidine and erythromycin on hepatic CYP3A activities in cats .
22789530	0	ketoconazole	118,130	CYP3A	101,106	ketoconazole	CYP3A	MESH:D007654	1576	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|clearance clearance|acl:relcl|administering administering|nmod|inhibitor inhibitor|compound|END_ENTITY	The effects on metabolic clearance when administering a potent CYP3A autoinducer with the prototypic CYP3A inhibitor , ketoconazole .
22789530	0	ketoconazole	118,130	CYP3A	63,68	ketoconazole	CYP3A	MESH:D007654	1576	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|clearance clearance|acl:relcl|administering administering|dobj|autoinducer autoinducer|compound|END_ENTITY	The effects on metabolic clearance when administering a potent CYP3A autoinducer with the prototypic CYP3A inhibitor , ketoconazole .
22968811	0	ketoconazole	30,42	CYP3A	14,19	ketoconazole	CYP3A	MESH:D007654	1576	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|inhibitor inhibitor|compound|END_ENTITY	Effect of the CYP3A inhibitor ketoconazole on the PXR-mediated induction of CYP3A activity .
22968811	0	ketoconazole	30,42	CYP3A	76,81	ketoconazole	CYP3A	MESH:D007654	1576	Chemical	Gene	START_ENTITY|nmod|induction induction|nmod|activity activity|compound|END_ENTITY	Effect of the CYP3A inhibitor ketoconazole on the PXR-mediated induction of CYP3A activity .
23584886	0	ketoconazole	156,168	CYP3A	136,141	ketoconazole	CYP3A	MESH:D007654	1576	Chemical	Gene	based|nmod|START_ENTITY based|nmod|prediction prediction|nmod|inhibition inhibition|compound|END_ENTITY	Optimization of drug-drug interaction study design : comparison of minimal physiologically based pharmacokinetic models on prediction of CYP3A inhibition by ketoconazole .
24692738	0	ketoconazole	31,43	CYP3A	54,59	ketoconazole	CYP3A	MESH:D007654	1576	Chemical	Gene	co-administration|nmod|START_ENTITY Effect|nmod|co-administration Effect|appos|inhibitor inhibitor|compound|END_ENTITY	Effect of co-administration of ketoconazole , a strong CYP3A inhibitor , on the pharmacokinetics , safety and tolerability of navitoclax , a first-in-class oral Bcl-2 family inhibitor , in cancer patients .
24747234	0	ketoconazole	35,47	CYP3A	74,79	ketoconazole	CYP3A	MESH:D007654	1576	Chemical	Gene	alternatives|amod|START_ENTITY Itraconazole|nmod|alternatives Itraconazole|nmod|studies studies|compound|END_ENTITY	Itraconazole and clarithromycin as ketoconazole alternatives for clinical CYP3A inhibition studies .
25106415	0	ketoconazole	41,53	CYP3A	9,14	ketoconazole	CYP3A	MESH:D007654	1576	Chemical	Gene	alternatives|nmod|START_ENTITY alternatives|compound|END_ENTITY	Clinical CYP3A inhibitor alternatives to ketoconazole , clarithromycin and itraconazole , are not transported into the liver by hepatic organic anion transporting polypeptides and organic_cation_transporter_1 .
26272330	0	ketoconazole	49,61	CYP3A	32,37	ketoconazole	CYP3A	MESH:D007654	1576	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Exploratory effects of a strong CYP3A inhibitor -LRB- ketoconazole -RRB- , a strong CYP3A inducer -LRB- rifampicin -RRB- , and concomitant ethanol on piragliatin pharmacokinetics and pharmacodynamics in type 2 diabetic patients .
7937537	0	ketoconazole	70,82	CYP3A	20,25	ketoconazole	CYP3A	MESH:D007654	1576	Chemical	Gene	catalyzed|advcl|START_ENTITY catalyzed|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of human CYP3A catalyzed 1 ' - hydroxy_midazolam formation by ketoconazole , nifedipine , erythromycin , cimetidine , and nizatidine .
10801218	0	ketoconazole	35,47	CYP3A4	25,31	ketoconazole	CYP3A4	MESH:D007654	1576	Chemical	Gene	Persistent|nmod|START_ENTITY Persistent|dobj|inhibition inhibition|nmod|END_ENTITY	Persistent inhibition of CYP3A4 by ketoconazole in modified Caco-2 cells .
14712470	0	ketoconazole	68,80	CYP3A4	57,63	ketoconazole	CYP3A4	MESH:D007654	1576	Chemical	Gene	cytochrome_P450_3A4|nmod|START_ENTITY cytochrome_P450_3A4|appos|END_ENTITY	Enantioselectivity of inhibition of cytochrome_P450_3A4 -LRB- CYP3A4 -RRB- by ketoconazole : Testosterone and methadone as substrates .
15618724	4	ketoconazole	919,931	CYP3A4	911,917	ketoconazole	CYP3A4	MESH:D007654	1576	Chemical	Gene	inhibitors|dep|START_ENTITY inhibitors|nmod|END_ENTITY	The CL -LRB- int -RRB- of CAM was markedly reduced by selective inhibitors of CYP3A4 -LRB- ketoconazole and troleandomycin -RRB- and by polyclonal antibodies raised against CYP3A4/5 in human liver microsomes .
17200836	0	ketoconazole	82,94	CYP3A4	14,20	ketoconazole	CYP3A4	MESH:D007654	1576	Chemical	Gene	catalyzed|nmod|START_ENTITY catalyzed|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of CYP3A4 and CYP3A5 catalyzed metabolism of alprazolam and quinine by ketoconazole as racemate and four different enantiomers .
18574557	0	ketoconazole	30,42	CYP3A4	53,59	ketoconazole	CYP3A4	MESH:D007654	1576	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Effect of coadministration of ketoconazole , a strong CYP3A4 inhibitor , on pharmacokinetics and tolerability of motesanib_diphosphate -LRB- AMG_706 -RRB- in patients with advanced solid_tumors .
19077665	0	ketoconazole	35,47	CYP3A4	14,20	ketoconazole	CYP3A4	MESH:D007654	1576	Chemical	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Inhibition of CYP3A4 expression by ketoconazole is mediated by the disruption of pregnane_X_receptor , steroid receptor coactivator-1 , and hepatocyte_nuclear_factor_4alpha interaction .
20945304	0	ketoconazole	78,90	CYP3A4	53,59	ketoconazole	CYP3A4	MESH:D007654	1576	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|nmod|testosterone testosterone|nmod|END_ENTITY	Human cytochrome_P450 : metabolism of testosterone by CYP3A4 and inhibition by ketoconazole .
25343516	0	ketoconazole	16,28	CYP3A4	48,54	ketoconazole	CYP3A4	MESH:D007654	1576	Chemical	Gene	cis-enantiomers|amod|START_ENTITY cis-enantiomers|nmod|END_ENTITY	Dual effects of ketoconazole cis-enantiomers on CYP3A4 in human hepatocytes and HepG2 Cells .
9179989	0	ketoconazole	133,145	CYP3A4	115,121	ketoconazole	CYP3A4	MESH:D007654	479740(Tax:9615)	Chemical	Gene	protease|xcomp|START_ENTITY protease|nmod|coadministration coadministration|nmod|inhibitor inhibitor|compound|END_ENTITY	Improvement of bioavailability of the HIV protease inhibitor SC-52151 in the beagle_dog by coadministration of the CYP3A4 inhibitor , ketoconazole .
22587011	0	ketoconazole	34,46	Cytochrome_P450_3A4	0,19	ketoconazole	Cytochrome P450 3A4	MESH:D007654	1576	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|END_ENTITY	Cytochrome_P450_3A4 inhibition by ketoconazole : tackling the problem of ligand cooperativity using molecular dynamics simulations and free-energy calculations .
21456052	0	ketoconazole	22,34	OAT1	51,55	ketoconazole	OAT1	MESH:D007654	9356	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activities activities|compound|END_ENTITY	Inhibitory effects of ketoconazole and rifampin on OAT1 and OATP1B1 transport activities : considerations on drug-drug interactions .
17152347	0	ketoconazole	10,22	P-glycoprotein	124,138	ketoconazole	P-glycoprotein	MESH:D007654	5243	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|role role|nmod|END_ENTITY	Effect of ketoconazole and rifampicin on the pharmacokinetics of ranitidine in healthy human volunteers : a possible role of P-glycoprotein .
25000292	0	ketoconazole	27,39	aryl_hydrocarbon_receptor	43,68	ketoconazole	aryl hydrocarbon receptor	MESH:D007654	196	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Enantiospecific effects of ketoconazole on aryl_hydrocarbon_receptor .
26363502	0	ketoconazole	40,52	aryl_hydrocarbon_receptor	84,109	ketoconazole	aryl hydrocarbon receptor	MESH:D007654	196	Chemical	Gene	contained|nmod|START_ENTITY Impurities|acl|contained activators|nsubj|Impurities activators|nmod|END_ENTITY	Impurities contained in antifungal drug ketoconazole are potent activators of human aryl_hydrocarbon_receptor .
12061540	0	ketoconazole	55,67	cytochrome_P-450	95,111	ketoconazole	cytochrome P-450	MESH:D007654	487648(Tax:9615)	Chemical	Gene	START_ENTITY|nmod|activities activities|nmod|END_ENTITY	In vitro characterization of the inhibitory effects of ketoconazole on metabolic activities of cytochrome_P-450 in canine hepatic microsomes .
2799848	0	ketoconazole	63,75	cytochrome_P-450	93,109	ketoconazole	cytochrome P-450	MESH:D007654	25251(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Oxidative metabolism of cholesterol precursors : sensitivity to ketoconazole , an inhibitor of cytochrome_P-450 .
3841572	0	ketoconazole	70,82	cytochrome_P-450	28,44	ketoconazole	cytochrome P-450	MESH:D007654	25251(Tax:10116)	Chemical	Gene	drugs|amod|START_ENTITY testis|nmod|drugs testis|nsubj|Inhibition Inhibition|nmod|enzymes enzymes|amod|END_ENTITY	Inhibition of steroidogenic cytochrome_P-450 enzymes in rat testis by ketoconazole and related imidazole anti-fungal drugs .
20945304	0	ketoconazole	78,90	cytochrome_P450	6,21	ketoconazole	cytochrome P450	MESH:D007654	4051	Chemical	Gene	metabolism|nmod|START_ENTITY END_ENTITY|dep|metabolism	Human cytochrome_P450 : metabolism of testosterone by CYP3A4 and inhibition by ketoconazole .
23006841	0	ketoconazole	31,43	cytochrome_P450	4,19	ketoconazole	cytochrome P450	MESH:D007654	4051	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	The cytochrome_P450 inhibitor , ketoconazole , inhibits oxidized linoleic_acid metabolite-mediated peripheral inflammatory_pain .
23710083	0	ketoconazole	10,22	cytochrome_P450	26,41	ketoconazole	cytochrome P450	MESH:D007654	13079(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effect of ketoconazole , a cytochrome_P450 inhibitor , on the efficacy of quinine and halofantrine against Schistosoma_mansoni in mice .
1984567	0	ketoconazole	38,50	familial_hypercholesterolemia	86,115	ketoconazole	familial hypercholesterolemia	MESH:D007654	3949	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Hypolipidemic effect and mechanism of ketoconazole without and with cholestyramine in familial_hypercholesterolemia .
7868804	0	ketoconazole	60,72	insulin	88,95	ketoconazole	insulin	MESH:D007654	3630	Chemical	Gene	Reduction|nmod|START_ENTITY alter|nsubj|Reduction alter|dobj|response response|compound|END_ENTITY	Reduction of endogenous , ovarian and adrenal androgens with ketoconazole does not alter insulin response in the polycystic_ovary_syndrome .
17152348	0	ketoconazole	10,22	p-glycoprotein	81,95	ketoconazole	p-glycoprotein	MESH:D007654	5243	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|role role|nmod|END_ENTITY	Effect of ketoconazole on the pharmacokinetics of ornidazole -- a possible role of p-glycoprotein and CYP3A .
17438109	0	ketoconazole	50,62	pregnenolone_X-receptor	10,33	ketoconazole	pregnenolone X-receptor	MESH:D007654	8856	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Activated pregnenolone_X-receptor is a target for ketoconazole and its analogs .
19076380	0	ketoconazole	48,60	proopiomelanocortin	18,37	ketoconazole	proopiomelanocortin	MESH:D007654	5443	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Activation of the proopiomelanocortin gene with ketoconazole as a treatment for Parkinson 's _ disease : a new hypothesis .
16423372	0	ketolide	28,36	cytochrome_P450	112,127	ketolide	cytochrome P450	null	25251(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of a newly developed ketolide antibiotic , telithromycin , on metabolism of theophylline and expression of cytochrome_P450 in rats .
16606345	0	ketomethylene	6,19	angiotensin_I-converting_enzyme	34,65	ketomethylene	angiotensin I-converting enzyme	null	1636	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|nmod|END_ENTITY	Novel ketomethylene inhibitors of angiotensin_I-converting_enzyme -LRB- ACE -RRB- : inhibition and molecular modelling .
2675847	0	ketone	94,100	aldehyde_reductase	118,136	ketone	aldehyde reductase	CHEBI:17087	14187(Tax:10090)	Chemical	Gene	reduced|nsubjpass|START_ENTITY reduced|nmod|END_ENTITY	Purification and properties of a metyrapone-reducing enzyme from mouse liver microsomes -- this ketone is reduced by an aldehyde_reductase .
6348066	0	ketone	13,19	growth_hormone	44,58	ketone	growth hormone	CHEBI:17087	2688	Chemical	Gene	infusion|amod|START_ENTITY infusion|nmod|END_ENTITY	Influence of ketone body infusion on plasma growth_hormone and glucagon in man .
6814209	0	ketone_hydrazones	37,54	lipoxygenase-1	8,22	ketone hydrazones	lipoxygenase-1	null	547923(Tax:3847)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Soybean lipoxygenase-1 inhibition by ketone_hydrazones .
23927272	0	ketones	71,78	CO2	96,99	ketones	CO2	MESH:D007659	717	Chemical	Gene	associated|nmod|START_ENTITY associated|nmod|END_ENTITY	Investigation of attractive and repulsive interactions associated with ketones in supercritical CO2 , based on Raman spectroscopy and theoretical calculations .
11602526	0	ketones	126,133	CYP3A11	137,144	ketones	CYP3A11	MESH:D007659	13112(Tax:10090)	Chemical	Gene	mechanism|nmod|START_ENTITY mechanism|nmod|END_ENTITY	Oxidation mechanism of 7-hydroxy-delta_8-tetrahydrocannabinol and 8-hydroxy-delta_9-tetrahydrocannabinol to the corresponding ketones by CYP3A11 .
17107796	0	ketopiperazine	34,48	MCH-R1	49,55	ketopiperazine	MCH-R1	null	2847	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|compound|END_ENTITY	Aminomethyl tetrahydronaphthalene ketopiperazine MCH-R1 antagonists -- Increasing selectivity over hERG .
9094200	0	ketoprofen	35,45	CD-1	49,53	ketoprofen	CD-1	MESH:D007660	111334(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|compound|END_ENTITY	Bi-directional chiral inversion of ketoprofen in CD-1 mice .
10673309	0	ketoprofen	40,50	Interferon-alpha_2b	0,19	ketoprofen	Interferon-alpha 2b	MESH:D007660	3440	Chemical	Gene	administration|compound|START_ENTITY END_ENTITY|nmod|administration	Interferon-alpha_2b combined with daily ketoprofen administration improves virological response in chronic hepatitis_C : a prospective and randomised trial .
7759142	0	ketorolac_tromethamine	11,33	erythropoietin	37,51	ketorolac tromethamine	erythropoietin	MESH:D020911	24335(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|compound|END_ENTITY	Effects of ketorolac_tromethamine on erythropoietin levels in Sprague_Dawley_rats .
2329018	0	ketotifen	10,19	IL-2	54,58	ketotifen	IL-2	MESH:D007665	3558	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of ketotifen on antigen-induced interleukin_2 -LRB- IL-2 -RRB- responsiveness in lymphocytes from patients with atopic_dermatitis_and / or_bronchial_asthma .
8587780	0	ketotifen	50,59	Major_basic_protein	0,19	ketotifen	Major basic protein	MESH:D007665	4155	Chemical	Gene	administration|nmod|START_ENTITY administration|compound|END_ENTITY	Major_basic_protein and topical administration of ketotifen in pollinosis under natural allergen provocation .
6134616	0	kirromycin	91,101	elongation-factor-Tu	68,88	kirromycin	elongation-factor-Tu	MESH:C008536	1915	Chemical	Gene	complex|compound|START_ENTITY complex|amod|END_ENTITY	Interaction between the different domains of aminoacyl-tRNA and the elongation-factor-Tu x kirromycin complex .
21511059	0	kobophenol_A	21,33	JNK	126,129	kobophenol A	JNK	MESH:C510380	5599	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|involvement involvement|nmod|pathways pathways|compound|END_ENTITY	Protective effect of kobophenol_A on nitric_oxide-induced cell apoptosis in human osteoblast-like MG-63 cells : involvement of JNK , NF-kB and AP-1 pathways .
16244458	2	kojic_acid	303,313	tyrosinase	207,217	kojic acid	tyrosinase	MESH:C011890	7299	Chemical	Gene	activity|nmod|START_ENTITY times|dep|activity microM|acl:relcl|times value|nmod|microM inhibited|nmod|value inhibited|dobj|END_ENTITY	It inhibited mushroom tyrosinase with an IC50 value of 9.2 microM , which is six times the anti-tyrosinase activity of kojic_acid -LRB- IC50 = 54.4 microM -RRB- .
16511808	0	kojic_acid	35,45	tyrosinase	13,23	kojic acid	tyrosinase	MESH:C011890	7299	Chemical	Gene	START_ENTITY|nsubj|Synthesis Synthesis|nmod|inhibitory inhibitory|amod|END_ENTITY	Synthesis of tyrosinase inhibitory kojic_acid derivative .
18966455	0	kojic_acid	21,31	tyrosinase	133,143	kojic acid	tyrosinase	MESH:C011890	7299	Chemical	Gene	START_ENTITY|advcl|effect effect|acl|substrate substrate|dobj|recycling recycling|acl|driven driven|nmod|END_ENTITY	Chemically amplified kojic_acid responses of tyrosinase-based biosensor , based on inhibitory effect to substrate recycling driven by tyrosinase and l-ascorbic_acid .
20619644	2	kojic_acid	433,443	tyrosinase	316,326	kojic acid	tyrosinase	MESH:C011890	7299	Chemical	Gene	activity|nmod|START_ENTITY potent|nmod|activity microM|acl:relcl|potent value|nmod|microM inhibited|nmod|value inhibited|dobj|END_ENTITY	5HNB inhibited mushroom tyrosinase with an IC -LRB- 50 -RRB- value of 2.95 microM , which is more potent than the well-known anti-tyrosinase activity of kojic_acid -LRB- IC -LRB- 50 -RRB- = 38.24 -RRB- .
22579419	0	kojic_acid	27,37	tyrosinase	58,68	kojic acid	tyrosinase	MESH:C011890	7299	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|activities activities|amod|END_ENTITY	Depigmenting activities of kojic_acid derivatives without tyrosinase inhibitory activities .
24148524	0	kojic_acid	71,81	tyrosinase	85,95	kojic acid	tyrosinase	MESH:C011890	7299	Chemical	Gene	effect|nmod|START_ENTITY monitoring|dobj|effect monitoring|nmod|END_ENTITY	A chiral ligand exchange CE system for monitoring inhibitory effect of kojic_acid on tyrosinase .
25004069	0	kojic_acid	55,65	tyrosinase	79,89	kojic acid	tyrosinase	MESH:C011890	7299	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Combined kinetic studies and computational analysis on kojic_acid analogous as tyrosinase inhibitors .
26235587	7	kojic_acid	949,959	tyrosinase	1202,1212	kojic acid	tyrosinase	MESH:C011890	22173(Tax:10090)	Chemical	Gene	has|advcl|START_ENTITY has|advcl|forming forming|nmod|residues residues|nmod|END_ENTITY	As an underlying mechanism , docking simulation showed that compared to kojic_acid , a well-known competitive tyrosinase inhibitor which forms a hydrogen bond and aromatic interaction with tyrosinase , MHY2081 has stronger affinity with tyrosinase by forming three hydrogen bonds and a hydrophobic interaction with residues of tyrosinase .
26631438	3	kojic_acid	638,648	tyrosinase	598,608	kojic acid	tyrosinase	MESH:C011890	22173(Tax:10090)	Chemical	Gene	that|nmod|START_ENTITY higher|nmod|that higher|nsubj|affinity affinity|nmod|CPA2 CPA2|nmod|END_ENTITY	Results from the docking simulation indicated that CPA2 could bind directly to the active site of mushroom tyrosinase and the binding affinity of CPA2 for tyrosinase might be higher than that of kojic_acid , a well-known potent tyrosinase inhibitor .
27081457	0	kojic_acid	71,81	tyrosinase	97,107	kojic acid	tyrosinase	MESH:C011890	7299	Chemical	Gene	START_ENTITY|nmod|enzyme enzyme|amod|END_ENTITY	In vitro and in silico studies of the inhibitory effects of some novel kojic_acid derivatives on tyrosinase enzyme .
2015292	0	koningic_acid	18,31	glyceraldehyde-3-phosphate_dehydrogenase	81,121	koningic acid	glyceraldehyde-3-phosphate dehydrogenase	MESH:C027285	100009074(Tax:9986)	Chemical	Gene	Identification|nmod|START_ENTITY Identification|dep|site site|nmod|END_ENTITY	Identification of koningic_acid -LRB- heptelidic_acid -RRB- - modified site in rabbit muscle glyceraldehyde-3-phosphate_dehydrogenase .
2226438	0	koningic_acid	63,76	glyceraldehyde-3-phosphate_dehydrogenase	4,44	koningic acid	glyceraldehyde-3-phosphate dehydrogenase	MESH:C027285	2597	Chemical	Gene	isozymes|nmod|START_ENTITY isozymes|amod|END_ENTITY	Two glyceraldehyde-3-phosphate_dehydrogenase isozymes from the koningic_acid -LRB- heptelidic_acid -RRB- producer Trichoderma koningii .
3090941	0	krestin	12,19	PSK	21,24	krestin	PSK	MESH:C010770	381921(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	-LSB- Effects of krestin -LRB- PSK -RRB- on drug-metabolizing enzymes with special reference to the activation of FT-207 -RSB- .
25872573	0	kynurenic_acid	92,106	CA1	133,136	kynurenic acid	CA1	MESH:D007736	759	Chemical	Gene	START_ENTITY|nmod|region region|compound|END_ENTITY	Ischemic preconditioning protects neurons from damage and maintains the immunoreactivity of kynurenic_acid in the gerbil hippocampal CA1 region following transient cerebral_ischemia .
25064444	0	kynurenic_acid	62,76	a7_nicotinic_acetylcholine_receptor	15,50	kynurenic acid	a7 nicotinic acetylcholine receptor	MESH:D007736	1139	Chemical	Gene	START_ENTITY|nsubj|antagonist antagonist|amod|END_ENTITY	The endogenous a7_nicotinic_acetylcholine_receptor antagonist kynurenic_acid modulates amyloid-b-induced inflammation in BV-2 microglial cells .
21336543	0	kynurenic_acid	32,46	tumour_necrosis_factor-a	86,110	kynurenic acid	tumour necrosis factor-a	MESH:D007736	7124	Chemical	Gene	effects|nmod|START_ENTITY kynurenic_acid|nsubj|effects kynurenic_acid|nmod|production production|amod|END_ENTITY	Different inhibitory effects of kynurenic_acid and a novel kynurenic_acid analogue on tumour_necrosis_factor-a -LRB- TNF-a -RRB- production by mononuclear cells , HMGB1 production by monocytes and HNP1-3 secretion by neutrophils .
21336543	0	kynurenic_acid	59,73	tumour_necrosis_factor-a	86,110	kynurenic acid	tumour necrosis factor-a	MESH:D007736	7124	Chemical	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Different inhibitory effects of kynurenic_acid and a novel kynurenic_acid analogue on tumour_necrosis_factor-a -LRB- TNF-a -RRB- production by mononuclear cells , HMGB1 production by monocytes and HNP1-3 secretion by neutrophils .
9870556	0	kynurenine	58,68	3-hydroxyanthranilate_oxidase	21,50	kynurenine	3-hydroxyanthranilate oxidase	CHEBI:16946	23498	Chemical	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	Effects of oxygen on 3-hydroxyanthranilate_oxidase of the kynurenine pathway .
18079112	0	kynurenine	41,51	Histone_deacetylase	0,19	kynurenine	Histone deacetylase	CHEBI:16946	855987(Tax:4932)	Chemical	Gene	START_ENTITY|nsubj|modulates modulates|amod|END_ENTITY	Histone_deacetylase inhibition modulates kynurenine pathway activation in yeast , microglia , and mice expressing a mutant huntingtin fragment .
15866519	0	kynurenine	100,110	arylformamidase	10,25	kynurenine	arylformamidase	CHEBI:16946	71562(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of arylformamidase -LRB- kynurenine formamidase -RRB- gene inactivation in mice on enzymatic activity , kynurenine pathway metabolites and phenotype .
8769859	0	kynurenine	18,28	interferon-gamma	50,66	kynurenine	interferon-gamma	CHEBI:16946	15978(Tax:10090)	Chemical	Gene	pathway|amod|START_ENTITY pathway|nmod|END_ENTITY	Regulation of the kynurenine metabolic pathway by interferon-gamma in murine cloned macrophages and microglial cells .
19918244	0	kynurenines	43,54	IFN-alpha	86,95	kynurenines	IFN-alpha	null	3439	Chemical	Gene	START_ENTITY|nmod|stimulation stimulation|nmod|END_ENTITY	CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-alpha : relationship to CNS immune responses and depression .
26551350	0	l-Amino_Acids	70,83	Calcium-Sensing_Receptor	0,24	l-Amino Acids	Calcium-Sensing Receptor	null	846	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|dep|Effects	Calcium-Sensing_Receptor -LRB- CaSR -RRB- - Mediated Anti-inflammatory Effects of l-Amino_Acids in Intestinal Epithelial Cells .
25682972	0	l-Arginine	0,10	KIM-1	111,116	l-Arginine	KIM-1	CHEBI:16467	286934(Tax:10116)	Chemical	Gene	attenuates|amod|START_ENTITY attenuates|dep|role role|nmod|END_ENTITY	l-Arginine attenuates the ethylene_glycol induced urolithiasis in ininephrectomized hypertensive rats : role of KIM-1 , NGAL , and NOs .
16662346	0	l-Canavanine	0,12	Bean	32,36	l-Canavanine	Bean	CHEBI:405237	146227	Chemical	Gene	Metabolism|amod|START_ENTITY Metabolism|nmod|END_ENTITY	l-Canavanine Metabolism in Jack Bean , Canavalia ensiformis -LRB- L. -RRB- DC .
16663877	0	l-Canavanine	0,12	Bean	58,62	l-Canavanine	Bean	CHEBI:405237	146227	Chemical	Gene	Transport|amod|START_ENTITY Transport|acl|Developing Developing|dobj|END_ENTITY	l-Canavanine Transport and Utilization in Developing Jack Bean , Canavalia ensiformis -LRB- L. -RRB- DC .
18397228	10	l-Kyn	1787,1792	IDO	1759,1762	l-Kyn	IDO	null	3620	Chemical	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	Our findings provide evidence that hepatocyte itself expresses IDO and increases levels of l-Kyn in the blood in acute lethal hepatitis of mice .
25572761	0	l-NAME	43,49	LCAT	65,69	l-NAME	LCAT	null	24530(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|amod|END_ENTITY	NO levels in diabetes_mellitus : Effects of l-NAME and insulin on LCAT , Na -LRB- + -RRB- / K -LRB- + -RRB- ATPase activity and lipid profile .
23832324	0	l-arginine	117,127	p53	92,95	l-arginine	p53	CHEBI:16467	22060(Tax:10090)	Chemical	Gene	activity|amod|START_ENTITY END_ENTITY|nmod|activity	Arginase-II induces vascular smooth muscle cell senescence and apoptosis through p66Shc and p53 independently of its l-arginine ureahydrolase activity : implications for atherosclerotic_plaque vulnerability .
15451031	0	l-ascorbic_acid	54,69	Raf1	14,18	l-ascorbic acid	Raf1	MESH:D001205	5894	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of Raf1 and the ERK pathway in response to l-ascorbic_acid in acute_myeloid_leukemia cells .
25910559	0	l-ascorbic_acid	9,24	vascular_endothelium_growth_factor	74,108	l-ascorbic acid	vascular endothelium growth factor	MESH:D001205	83785(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|iobj|END_ENTITY	Buffered l-ascorbic_acid , alone or bound to KMUP-1 or sildenafil , reduces vascular_endothelium_growth_factor and restores endothelium nitric_oxide synthase in hypoxic_pulmonary_artery .
25661380	0	l-carnitine	60,71	NF-E2-related_factor_2	8,30	l-carnitine	NF-E2-related factor 2	MESH:D002331	4780	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nmod|effect	Role of NF-E2-related_factor_2 in neuroprotective effect of l-carnitine against high glucose-induced oxidative stress in the retinal ganglion cells .
26889770	0	l-carnitine	0,11	Nrf2	113,117	l-carnitine	Nrf2	MESH:D002331	4780	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|activation activation|nmod|END_ENTITY	l-carnitine protects human hepatocytes from oxidative stress-induced toxicity through Akt-mediated activation of Nrf2 signaling pathway .
25219528	0	l-cysteine	0,10	ghrelin	22,29	l-cysteine	ghrelin	MESH:D003545	58991(Tax:10090)	Chemical	Gene	suppresses|amod|START_ENTITY END_ENTITY|nsubj|suppresses	l-cysteine suppresses ghrelin and reduces appetite in rodents and humans .
11136730	0	l-dopa	49,55	tyrosinase	81,91	l-dopa	tyrosinase	MESH:D007980	7299	Chemical	Gene	oxidations|nmod|START_ENTITY nitric_oxide|nmod|oxidations effects|nmod|nitric_oxide mediated|nsubj|effects mediated|nmod|END_ENTITY	The effects of nitric_oxide on the oxidations of l-dopa and dopamine mediated by tyrosinase and peroxidase .
18931571	0	l-leucovorin	47,59	CPT-11	18,24	l-leucovorin	CPT-11	null	963084(Tax:115711)	Chemical	Gene	therapy|amod|START_ENTITY therapy|amod|END_ENTITY	-LSB- Phase I study of CPT-11 and continuous 5-FU / l-leucovorin combination therapy -LRB- modified AIO regimen -RRB- in patients with metastatic colorectal_cancer -RSB- .
25957199	0	l-mimosine	21,31	eIF3a	89,94	l-mimosine	eIF3a	CHEBI:29063	691947(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|Role Role|nmod|END_ENTITY	Inhibitory effect of l-mimosine on bleomycin-induced pulmonary_fibrosis in rats : Role of eIF3a and p27 .
7216145	0	l-phenylalanine	55,70	pancreatic_polypeptide	15,37	l-phenylalanine	pancreatic polypeptide	CHEBI:58095	490944(Tax:9615)	Chemical	Gene	release|nmod|START_ENTITY release|nmod|END_ENTITY	The release of pancreatic_polypeptide by intraduodenal l-phenylalanine in the dog .
16033257	0	l-prolyl-pyrrolidine_amides	27,54	prolyl_oligopeptidase	58,79	l-prolyl-pyrrolidine amides	prolyl oligopeptidase	null	5550	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Dicarboxylic_acid azacycle l-prolyl-pyrrolidine_amides as prolyl_oligopeptidase inhibitors and three-dimensional quantitative structure-activity relationship of the enzyme-inhibitor interactions .
26706043	0	l-rhamnose	0,10	insulin	54,61	l-rhamnose	insulin	CHEBI:62346	3630	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|compound|END_ENTITY	l-rhamnose as a source of colonic propionate inhibits insulin secretion but does not influence measures of appetite or food intake .
11567059	0	l-serine	51,59	3-Phosphoglycerate_dehydrogenase	0,32	l-serine	3-Phosphoglycerate dehydrogenase	CHEBI:33384	236539(Tax:10090)	Chemical	Gene	biosynthesis|amod|START_ENTITY enzyme|nmod|biosynthesis END_ENTITY|appos|enzyme	3-Phosphoglycerate_dehydrogenase , a key enzyme for l-serine biosynthesis , is preferentially expressed in the radial glia/astrocyte lineage and olfactory ensheathing glia in the mouse brain .
5696864	0	l-serine	50,58	3-phosphoglycerate_dehydrogenase	14,46	l-serine	3-phosphoglycerate dehydrogenase	CHEBI:33384	26227	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of 3-phosphoglycerate_dehydrogenase by l-serine .
15578005	0	l-stepholidine	11,25	Fos	39,42	l-stepholidine	Fos	null	2353	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effects of l-stepholidine on forebrain Fos expression : comparison with clozapine and haloperidol .
1456049	0	l-stepholidine	11,25	calmodulin	72,82	l-stepholidine	calmodulin	null	24242(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|dep|END_ENTITY	Effects of l-stepholidine on synaptosomal Ca -LRB- 2 + -RRB- - ATPase and subcellular calmodulin in rat striatum .
1360740	0	l-stepholidine	11,25	tyrosine_hydroxylase	29,49	l-stepholidine	tyrosine hydroxylase	null	25085(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|amod|END_ENTITY	Effects of l-stepholidine on tyrosine_hydroxylase activity in rat corpus striatum .
3093910	0	l-thyroxine	70,81	TRH	30,33	l-thyroxine	TRH	MESH:D013974	7200	Chemical	Gene	therapy|amod|START_ENTITY END_ENTITY|nmod|therapy	Prolactin and TSH response to TRH and metoclopramide before and after l-thyroxine therapy in subclinical_hypothyroidism .
18965738	0	l-tyrosine	32,42	tyrosinase	69,79	l-tyrosine	tyrosinase	CHEBI:17895	7299	Chemical	Gene	determination|nmod|START_ENTITY determination|nmod|END_ENTITY	Flow-injection determination of l-tyrosine in serum with immobilized tyrosinase .
15505490	0	labedipinedilol-A	84,101	PKC	110,113	labedipinedilol-A	PKC	MESH:C500368	24681(Tax:10116)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of mitogen-mediated proliferation of rat vascular smooth muscle cells by labedipinedilol-A through PKC and ERK_1 / 2 pathway .
7105431	0	labetalol	37,46	Prolactin	0,9	labetalol	Prolactin	MESH:D007741	5617	Chemical	Gene	stimulation|nmod|START_ENTITY stimulation|compound|END_ENTITY	Prolactin stimulation by intravenous labetalol is mediated inside the central nervous system .
1897344	0	labetalol	88,97	renin	7,12	labetalol	renin	MESH:D007741	5972	Chemical	Gene	induced|nmod|START_ENTITY hypotension|acl|induced vasopressin|nmod|hypotension vasopressin|nsubj|END_ENTITY	Plasma renin , catecholamines , vasopressin and aldosterone during hypotension induced by labetalol with isoflurane .
520398	0	labetalol	15,24	renin	51,56	labetalol	renin	MESH:D007741	5972	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of oral labetalol on plasma catecholamines , renin and aldosterone in patients with severe arterial hypertension .
7033992	0	labetalol	48,57	renin	89,94	labetalol	renin	MESH:D007741	5972	Chemical	Gene	hypertension|nmod|START_ENTITY Treatment|nmod|hypertension Treatment|dep|effect effect|nmod|END_ENTITY	Treatment of severe essential hypertension with labetalol : effect on active and inactive renin .
94628	0	labetalol	11,20	renin	31,36	labetalol	renin	MESH:D007741	5972	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of labetalol on plasma renin , aldosterone , and catecholamines in hypertensive patients .
358932	0	labetol	32,39	renin	59,64	labetol	renin	null	5972	Chemical	Gene	START_ENTITY|nmod|system system|compound|END_ENTITY	-LSB- Effect of alpha , beta blocker , labetol on the angiotensin renin system in arterial hypertension -RSB- .
9868030	0	lacidipine	12,22	insulin	75,82	lacidipine	insulin	MESH:C060285	3630	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of lacidipine on serum oxygen free radicals and fasting levels of insulin in patients with essential hypertension -RSB- .
23551115	0	lacosamide	60,70	P-glycoprotein	25,39	lacosamide	P-glycoprotein	MESH:C403507	5243	Chemical	Gene	transport|nmod|START_ENTITY role|nmod|transport role|nmod|END_ENTITY	Potential role for human P-glycoprotein in the transport of lacosamide .
20538611	0	lacosamide	63,73	collapsin_response_mediator_protein-2	91,128	lacosamide	collapsin response mediator protein-2	MESH:C403507	25416(Tax:10116)	Chemical	Gene	sites|amod|START_ENTITY sites|nmod|END_ENTITY	In silico docking and electrophysiological characterization of lacosamide binding sites on collapsin_response_mediator_protein-2 identifies a pocket important in modulating sodium channel slow inactivation .
26522302	0	lactacystin	39,50	HDAC-6	10,16	lactacystin	HDAC-6	MESH:C067713	10013	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Effect Effect|nmod|END_ENTITY	Effect of HDAC-6 on PD cell induced by lactacystin .
18954406	0	lactadherin	105,116	annexin_V	142,151	lactadherin	annexin V	null	308	Chemical	Gene	START_ENTITY|dep|study study|nmod|END_ENTITY	Measurement of phosphatidylserine exposure during storage of platelet concentrates using the novel probe lactadherin : a comparison study with annexin_V .
6243254	0	lactalbumin	23,34	prolactin	10,19	lactalbumin	prolactin	null	5617	Chemical	Gene	production|compound|START_ENTITY Effect|nmod|production Effect|nmod|END_ENTITY	Effect of prolactin on lactalbumin production by normal and malignant human breast tissue in organ culture .
14531843	0	lactam	40,46	MT-II	62,67	lactam	MT-II	CHEBI:24995	4502	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	Extensive structure-activity studies of lactam derivatives of MT-II and SHU-9119 : their activity and selectivity at human melanocortin receptors 3 , 4 , and 5 .
17482720	0	lactam	38,44	MT-II	60,65	lactam	MT-II	CHEBI:24995	4502	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	Further structure-activity studies of lactam derivatives of MT-II and SHU-9119 : their activity and selectivity at human melanocortin receptors 3 , 4 , and 5 .
4329039	0	lactate	84,91	5-nucleotidase	251,265	lactate	5-nucleotidase	MESH:D019344	55	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	-LSB- Enzymatic activities of retina and anthocyanoside extracts of Vaccinium myrtillus -LRB- lactate dehydrogenase , alpha-hydroxybutyrate dehydrogenase , 6-phosphogluconate dehydrogenase , glucose-6-phosphate_dehydrogenase , alpha-glycerophosphate dehydrogenase , 5-nucleotidase , phosphoglucose_isomerase -RRB- -RSB- .
808014	0	lactate	82,89	ARP_and_AeP	69,80	lactate	ARP and AeP	MESH:D019344	473;5641	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	-LSB- Glycogen content and the activity of alkaline and acid phosphatase -LRB- ARP_and_AeP -RRB- lactate dehydrogenase -LRB- LDH -RRB- in the sow endometrium during the sexual cycle -RSB- .
15280926	0	lactate	126,133	C-reactive_protein	83,101	lactate	C-reactive protein	MESH:D019344	1401	Chemical	Gene	superior|xcomp|START_ENTITY superior|nsubj|END_ENTITY	Diagnosing melanoma patients entering American Joint Committee on Cancer stage IV , C-reactive_protein in serum is superior to lactate dehydrogenase .
2884389	0	lactate	24,31	CSF	20,23	lactate	CSF	MESH:D019344	1437	Chemical	Gene	START_ENTITY|nsubj|value value|nmod|END_ENTITY	Prognostic value of CSF lactate in cerebral_malaria .
7442916	0	lactate	16,23	CSF	12,15	lactate	CSF	MESH:D019344	1437	Chemical	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	-LSB- The serial CSF lactate and pyruvate levels as a guide to prognosis after severe head_injury -LRB- author 's transl -RRB- -RSB- .
10875893	0	lactate	36,43	Cu-Zn_superoxide_dismutase	0,26	lactate	Cu-Zn superoxide dismutase	MESH:D019344	20655(Tax:10090)	Chemical	Gene	release|amod|START_ENTITY inhibits|dobj|release inhibits|nsubj|END_ENTITY	Cu-Zn_superoxide_dismutase inhibits lactate dehydrogenase release and protects against cell death in murine fibroblasts pretreated with ultraviolet radiation .
3100457	0	lactate	35,42	Epidermal_growth_factor	0,23	lactate	Epidermal growth factor	MESH:D019344	25313(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Epidermal_growth_factor stimulates lactate production and inhibits aromatization in cultured Sertoli cells from immature rats .
3873645	0	lactate	104,111	Epidermal_growth_factor	0,23	lactate	Epidermal growth factor	MESH:D019344	25313(Tax:10116)	Chemical	Gene	dehydrogenase|amod|START_ENTITY levels|nmod|dehydrogenase elevation|nmod|levels induces|dobj|elevation induces|nsubj|stimulation stimulation|compound|END_ENTITY	Epidermal_growth_factor or serum stimulation of rat fibroblasts induces an elevation in mRNA levels for lactate dehydrogenase and other glycolytic enzymes .
23516535	0	lactate	42,49	Estrogen-related_receptor_alpha	0,31	lactate	Estrogen-related receptor alpha	MESH:D019344	2101	Chemical	Gene	START_ENTITY|nsubj|modulates modulates|amod|END_ENTITY	Estrogen-related_receptor_alpha modulates lactate dehydrogenase activity in thyroid_tumors .
25881750	0	lactate	4,11	G-protein-coupled_receptor_81	22,51	lactate	G-protein-coupled receptor 81	MESH:D019344	27198	Chemical	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	The lactate receptor , G-protein-coupled_receptor_81 / hydroxycarboxylic_acid_receptor_1 : Expression and action in brain .
4286914	0	lactate	33,40	Glyoxylate_reductase	0,20	lactate	Glyoxylate reductase	MESH:D019344	9380	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Glyoxylate_reductase activity of lactate dehydrogenase .
22428047	0	lactate	14,21	HIF-1	85,90	lactate	HIF-1	MESH:D019344	3091	Chemical	Gene	MCT1|amod|START_ENTITY Targeting|dobj|MCT1 inhibits|csubj|Targeting inhibits|dobj|activation activation|compound|END_ENTITY	Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis .
1538640	0	lactate	64,71	Insulin	0,7	lactate	Insulin	MESH:D019344	3630	Chemical	Gene	levels|compound|START_ENTITY associated|nmod|levels associated|nsubjpass|resistance resistance|compound|END_ENTITY	Insulin resistance in obesity is associated with elevated basal lactate levels and diminished lactate appearance following intravenous glucose and insulin .
17956836	0	lactate	61,68	Insulin	0,7	lactate	Insulin	MESH:D019344	3630	Chemical	Gene	levels|nmod|START_ENTITY affected|nmod|levels affected|nsubjpass|resistance resistance|compound|END_ENTITY	Insulin resistance is affected by increased levels of plasma lactate but not mitochondrial alterations in skeletal muscle in NRTI-exposed HIV-infected patients .
2660587	0	lactate	76,83	Insulin	0,7	lactate	Insulin	MESH:D019344	3630	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Insulin inhibition of overnight glucose production and gluconeogenesis from lactate in NIDDM .
6039828	0	lactate	23,30	Insulin	0,7	lactate	Insulin	MESH:D019344	3630	Chemical	Gene	oxidation|amod|START_ENTITY stimulation|nmod|oxidation stimulation|compound|END_ENTITY	Insulin stimulation of lactate oxidation and incorporation into glycogen in frog skeletal muscle .
6391212	0	lactate	22,29	Insulin	0,7	lactate	Insulin	MESH:D019344	3630	Chemical	Gene	infusion|amod|START_ENTITY levels|nmod|infusion levels|compound|END_ENTITY	Insulin levels during lactate infusion .
9342790	0	lactate	43,50	Insulin	0,7	lactate	Insulin	MESH:D019344	280829(Tax:9913)	Chemical	Gene	production|amod|START_ENTITY regulation|nmod|production dexamethasone|dobj|regulation dexamethasone|nsubj|and/or and/or|compound|END_ENTITY	Insulin and/or dexamethasone regulation of lactate production and its relationship to glucose utilization by ovine and bovine adipose_tissue explants incubated for 7 days .
9436687	0	lactate	23,30	Insulin	0,7	lactate	Insulin	MESH:D019344	3630	Chemical	Gene	accumulation|amod|START_ENTITY stimulation|nmod|accumulation stimulation|compound|END_ENTITY	Insulin stimulation of lactate accumulation in isolated human granulosa-luteal cells : a comparison between normal and polycystic_ovaries .
9892725	0	lactate	35,42	LDH-C	58,63	lactate	LDH-C	MESH:D019344	16833(Tax:10090)	Chemical	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	cDNA copies of the testis-specific lactate dehydrogenase -LRB- LDH-C -RRB- mRNA are present in spermatogenic cells in mice , but processed pseudogenes are not derived from mRNAs that are expressed in haploid and late meiotic spermatogenic cells .
16582413	0	lactate	16,23	LDH-C4	39,45	lactate	LDH-C4	MESH:D019344	16833(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|dehydrogenase dehydrogenase|appos|END_ENTITY	Testis-specific lactate dehydrogenase -LRB- LDH-C4 ; Ldh3 -RRB- in murine oocytes and preimplantation embryos .
2285453	0	lactate	76,83	LDH-C4	99,105	lactate	LDH-C4	MESH:D019344	16833(Tax:10090)	Chemical	Gene	dehydrogenase|amod|START_ENTITY isozyme|nmod|dehydrogenase mice|nmod|isozyme Immunization|nmod|mice Immunization|appos|END_ENTITY	Immunization of male but not female mice with the sperm-specific isozyme of lactate dehydrogenase -LRB- LDH-C4 -RRB- impairs fertilization in vivo .
417145	0	lactate	79,86	LDH-C4	102,108	lactate	LDH-C4	MESH:D019344	16833(Tax:10090)	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	Strain differences in the immune response of mice to homologous sperm-specific lactate dehydrogenase -LRB- LDH-C4 -RRB- .
2596827	0	lactate	44,51	LDHC	67,71	lactate	LDHC	MESH:D019344	3948	Chemical	Gene	dehydrogenase|compound|START_ENTITY localization|nmod|dehydrogenase localization|appos|END_ENTITY	Regional localization of the sperm-specific lactate dehydrogenase , LDHC , gene on human chromosome 11 .
2844458	0	lactate	43,50	LDHC	66,70	lactate	LDHC	MESH:D019344	3948	Chemical	Gene	dehydrogenase|compound|START_ENTITY dehydrogenase|appos|END_ENTITY	Locus determining the human sperm-specific lactate dehydrogenase , LDHC , is syntenic with LDHA .
9813024	0	lactate	59,66	LDHC	82,86	lactate	LDHC	MESH:D019344	16833(Tax:10090)	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	Transgenic_mice demonstrate a testis-specific promoter for lactate dehydrogenase , LDHC .
10590411	0	lactate	66,73	MCT1	13,17	lactate	MCT1	MESH:D019344	6566	Chemical	Gene	transport|amod|START_ENTITY Mutations|nmod|transport Mutations|nmod|cDNA cDNA|compound|END_ENTITY	Mutations in MCT1 cDNA in patients with symptomatic deficiency in lactate transport .
11052969	0	lactate	35,42	MCT1	56,60	lactate	MCT1	MESH:D019344	6566	Chemical	Gene	regulation|nmod|START_ENTITY transporters|nsubj|regulation transporters|dobj|END_ENTITY	Isoform-specific regulation of the lactate transporters MCT1 and MCT4 by contractile activity .
11820324	0	lactate	18,25	MCT1	40,44	lactate	MCT1	MESH:D019344	25027(Tax:10116)	Chemical	Gene	transporters|amod|START_ENTITY expression|nmod|transporters expression|appos|END_ENTITY	The expression of lactate transporters -LRB- MCT1 and MCT4 -RRB- in heart and muscle .
16434551	0	lactate	119,126	MCT1	18,22	lactate	MCT1	MESH:D019344	25027(Tax:10116)	Chemical	Gene	complex|amod|START_ENTITY evidence|nmod|complex Colocalization|dep|evidence Colocalization|nmod|END_ENTITY	Colocalization of MCT1 , CD147 , and LDH in mitochondrial inner membrane of L6 muscle cells : evidence of a mitochondrial lactate oxidation complex .
18523157	0	lactate	37,44	MCT1	84,88	lactate	MCT1	MESH:D019344	25027(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY increases|dobj|uptake increases|advcl|increasing increasing|dobj|expression expression|nmod|END_ENTITY	PGC-1alpha increases skeletal muscle lactate uptake by increasing the expression of MCT1 but not MCT2 or MCT4 .
19404741	0	lactate	30,37	MCT1	111,115	lactate	MCT1	MESH:D019344	6566	Chemical	Gene	transport|amod|START_ENTITY blocking|dobj|transport effects|acl|blocking slices|nsubj|effects slices|xcomp|using using|nmod|END_ENTITY	Metabolic effects of blocking lactate transport in brain cortical tissue slices using an inhibitor specific to MCT1 and MCT2 .
21059000	0	lactate	14,21	MCT1	35,39	lactate	MCT1	MESH:D019344	100009694(Tax:9796)	Chemical	Gene	cells|amod|START_ENTITY cells|amod|transporters transporters|dep|END_ENTITY	Expression of lactate transporters MCT1 , MCT2 and CD147 in the red blood cells of three horse breeds : Finnhorse , Standardbred and Thoroughbred .
24285728	0	lactate	9,16	MCT1	53,57	lactate	MCT1	MESH:D019344	6566	Chemical	Gene	export|amod|START_ENTITY Blocking|dobj|export glycolysis|dep|Blocking glycolysis|nsubj|Disables Disables|compound|END_ENTITY	Blocking lactate export by inhibiting the Myc target MCT1 Disables glycolysis and glutathione synthesis .
27026015	0	lactate	62,69	MCT1	40,44	lactate	MCT1	MESH:D019344	6566	Chemical	Gene	uptake|nmod|START_ENTITY END_ENTITY|nmod|uptake	Role of the monocarboxylate transporter MCT1 in the uptake of lactate during active recovery .
8760092	0	lactate	12,19	MCT1	33,37	lactate	MCT1	MESH:D019344	25027(Tax:10116)	Chemical	Gene	transporter|amod|START_ENTITY Role|nmod|transporter Role|appos|END_ENTITY	Role of the lactate transporter -LRB- MCT1 -RRB- in skeletal muscles .
9003367	0	lactate	59,66	MCT1	82,86	lactate	MCT1	MESH:D019344	25027(Tax:10116)	Chemical	Gene	cotransporter|compound|START_ENTITY cotransporter|appos|END_ENTITY	Studies of the membrane topology of the rat erythrocyte H + / lactate cotransporter -LRB- MCT1 -RRB- .
9458754	0	lactate	97,104	MCT1	43,47	lactate	MCT1	MESH:D019344	6566	Chemical	Gene	relation|nmod|START_ENTITY increases|nmod|relation increases|dobj|END_ENTITY	Short-term training increases human muscle MCT1 and femoral venous lactate in relation to muscle lactate .
23639941	0	lactate	28,35	MEK1/2	0,6	lactate	MEK1/2	MESH:D019344	5604;5605	Chemical	Gene	START_ENTITY|nsubj|decreases decreases|compound|END_ENTITY	MEK1/2 inhibition decreases lactate in BRAF-driven human cancer cells .
18542064	0	lactate	16,23	PDK-1	0,5	lactate	PDK-1	MESH:D019344	5163	Chemical	Gene	production|amod|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	PDK-1 regulates lactate production in hypoxia and is associated with poor prognosis in head_and_neck_squamous_cancer .
23650363	0	lactate	43,50	PGC-1a	16,22	lactate	PGC-1a	MESH:D019344	10891	Chemical	Gene	homeostasis|compound|START_ENTITY controls|dobj|homeostasis controls|nsubj|END_ENTITY	Skeletal muscle PGC-1a controls whole-body lactate homeostasis through estrogen-related receptor a-dependent activation of LDH B and repression of LDH_A .
17989297	0	lactate	44,51	Prion_protein	0,13	lactate	Prion protein	MESH:D019344	5621	Chemical	Gene	transport|compound|START_ENTITY regulates|dobj|transport regulates|nsubj|END_ENTITY	Prion_protein regulates glutamate-dependent lactate transport of astrocytes .
18086000	0	lactate	6,13	VEGFA	85,90	lactate	VEGFA	MESH:D019344	7422	Chemical	Gene	levels|compound|START_ENTITY correlate|nsubj|levels correlate|nmod|END_ENTITY	Serum lactate dehydrogenase levels and glycolysis significantly correlate with tumor VEGFA and VEGFR expression in metastatic CRC patients .
26853286	0	lactate	49,56	Vasopressin	24,35	lactate	Vasopressin	MESH:D019344	551	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	The Therapeutic Role of Vasopressin on Improving lactate Clearance During and After Vasogenic Shock : Microcirculation , Is It The Black Box ?
3609849	0	lactate	24,31	Vasopressin	0,11	lactate	Vasopressin	MESH:D019344	551	Chemical	Gene	infusion|amod|START_ENTITY response|nmod|infusion response|compound|END_ENTITY	Vasopressin response to lactate infusion in normals and patients with panic_disorder .
8174707	0	lactate	54,61	amylin	10,16	lactate	amylin	MESH:D019344	24476(Tax:10116)	Chemical	Gene	rise|nmod|START_ENTITY rise|nsubj|suppresses suppresses|compound|END_ENTITY	Selective amylin antagonist suppresses rise in plasma lactate after intravenous glucose in the rat .
6754378	0	lactate	47,54	cytochrome_b	31,43	lactate	cytochrome b	MESH:D019344	854583(Tax:4932)	Chemical	Gene	Reduction|nmod|START_ENTITY Reduction|nmod|END_ENTITY	Reduction of respiratory-chain cytochrome_b by lactate in Saccharomyces_cerevisiae .
1989512	0	lactate	36,43	epsilon-crystallin	75,93	lactate	epsilon-crystallin	MESH:D019344	101801152	Chemical	Gene	START_ENTITY|dobj|activity activity|nmod|END_ENTITY	Kinetic mechanism of the endogenous lactate dehydrogenase activity of duck epsilon-crystallin .
1489006	0	lactate	6,13	erythropoietin	116,130	lactate	erythropoietin	MESH:D019344	2056	Chemical	Gene	reduced|nsubjpass|START_ENTITY reduced|nmod|END_ENTITY	Blood lactate is reduced following successful treatment of anaemia in haemodialysis patients with recombinant human erythropoietin both at rest and after maximal exertion .
8846536	0	lactate	61,68	erythropoietin	14,28	lactate	erythropoietin	MESH:D019344	2056	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|END_ENTITY	The effect of erythropoietin on lactate , pyruvate and excess lactate under physical exercise in dialysis patients .
25934033	0	lactate	10,17	gonadotropin-releasing_hormone	37,67	lactate	gonadotropin-releasing hormone	MESH:D019344	25194(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Hindbrain lactate regulates preoptic gonadotropin-releasing_hormone -LRB- GnRH -RRB- neuron GnRH-I protein but not AMPK responses to hypoglycemia in the steroid-primed ovariectomized female rat .
11039668	0	lactate	18,25	granulocyte_colony-stimulating_factor	82,119	lactate	granulocyte colony-stimulating factor	MESH:D019344	1440	Chemical	Gene	START_ENTITY|nmod|administration administration|nmod|END_ENTITY	Analysis of serum lactate dehydrogenase and its isozymes during administration of granulocyte_colony-stimulating_factor in children .
9415351	0	lactate	64,71	haptoglobin	30,41	lactate	haptoglobin	MESH:D019344	3240	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|dep|END_ENTITY	Diagnostic value of ferritin , haptoglobin , alpha_1-antitrypsin , lactate dehydrogenase and complement factors C3_and_C4 in pleural_effusion differentiation .
1711025	0	lactate	174,181	hydrogenase	159,170	lactate	hydrogenase	MESH:D019344	2794485(Tax:882)	Chemical	Gene	metabolism|amod|START_ENTITY END_ENTITY|nmod|metabolism	Reduction of the amount of periplasmic hydrogenase in Desulfovibrio_vulgaris _ -LRB- Hildenborough -RRB- with antisense RNA : direct evidence for an important role of this hydrogenase in lactate metabolism .
1711025	0	lactate	174,181	hydrogenase	39,50	lactate	hydrogenase	MESH:D019344	2794485(Tax:882)	Chemical	Gene	metabolism|amod|START_ENTITY hydrogenase|nmod|metabolism role|nmod|hydrogenase evidence|nmod|role Reduction|dep|evidence Reduction|nmod|amount amount|nmod|END_ENTITY	Reduction of the amount of periplasmic hydrogenase in Desulfovibrio_vulgaris _ -LRB- Hildenborough -RRB- with antisense RNA : direct evidence for an important role of this hydrogenase in lactate metabolism .
25881750	0	lactate	4,11	hydroxycarboxylic_acid_receptor_1	52,85	lactate	hydroxycarboxylic acid receptor 1	MESH:D019344	27198	Chemical	Gene	receptor|amod|START_ENTITY receptor|dep|END_ENTITY	The lactate receptor , G-protein-coupled_receptor_81 / hydroxycarboxylic_acid_receptor_1 : Expression and action in brain .
20374952	1	lactate	45,52	insulin	68,75	lactate	insulin	MESH:D019344	3630	Chemical	Gene	involvement|amod|START_ENTITY involvement|nmod|action action|compound|END_ENTITY	: lactate involvement in insulin antilipolytic action .
3539288	0	lactate	59,66	insulin	10,17	lactate	insulin	MESH:D019344	105613195	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of insulin on gluconeogenesis and the metabolism of lactate in sheep .
736715	0	lactate	69,76	insulin	60,67	lactate	insulin	MESH:D019344	280829(Tax:9913)	Chemical	Gene	fatty_acids|dep|START_ENTITY fatty_acids|dep|END_ENTITY	-LSB- Behavior of various blood constituents -LRB- glucose , fructose , insulin , lactate , pyruvate , free fatty_acids , inorganic phosphate -RRB- and half-life of monosaccharides in the plasma after i.v. infusion of glucose , _ fructose , _ galactose and invert sugar solutions in ruminants .
736716	0	lactate	69,76	insulin	60,67	lactate	insulin	MESH:D019344	280829(Tax:9913)	Chemical	Gene	fatty_acids|dep|START_ENTITY fatty_acids|dep|END_ENTITY	-LSB- Behavior of various blood constituents -LRB- glucose , fructose , insulin , lactate , pyruvate , free fatty_acids , inorganic phosphate -RRB- and half-life of monosaccharides in the plasma after i.v. infusion of glucose , fructose , galactose and invert sugar solutions in ruminants .
736717	0	lactate	69,76	insulin	60,67	lactate	insulin	MESH:D019344	105613195	Chemical	Gene	fatty_acids|dep|START_ENTITY fatty_acids|dep|END_ENTITY	-LSB- Behavior of various blood constituents -LRB- glucose , fructose , insulin , lactate , pyruvate , free fatty_acids , inorganic phosphate -RRB- and the half-life of monosaccharides in plasma after i.v infusion of glucose , fructose , galactose and invert sugar solutions in ruminants .
2958671	0	lactate	77,84	myoglobin	34,43	lactate	myoglobin	MESH:D019344	4151	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|END_ENTITY	Sprint training effects on muscle myoglobin , enzymes , fiber types , and blood lactate .
6851084	0	lactate	51,58	myoglobin	17,26	lactate	myoglobin	MESH:D019344	4151	Chemical	Gene	START_ENTITY|nsubj|Changes Changes|nmod|END_ENTITY	Changes in serum myoglobin , total creatine kinase , lactate dehydrogenase and creatine kinase MB levels in runners .
7209295	0	lactate	52,59	myoglobin	24,33	lactate	myoglobin	MESH:D019344	4151	Chemical	Gene	START_ENTITY|nsubj|concentrations concentrations|nmod|END_ENTITY	Serum concentrations of myoglobin , creatine kinase , lactate dehydrogenase and cardiac isoenzymes in euthyroid , hypothyroid and hyperthyroid subjects .
9635277	0	lactate	14,21	myosin_heavy_chain	37,55	lactate	myosin heavy chain	MESH:D019344	100009284(Tax:9986)	Chemical	Gene	genes|amod|START_ENTITY genes|compound|END_ENTITY	Expression of lactate dehydrogenase , myosin_heavy_chain and myogenic regulatory factor genes in rabbit embryonic muscle cell cultures .
10194679	5	lactate	802,809	net	790,793	lactate	net	MESH:D019344	2004	Chemical	Gene	uptake|compound|START_ENTITY uptake|amod|END_ENTITY	Net hepatic glucose release , net hepatic lactate uptake , and net hepatic propionate uptake increased with increased milk production .
4329039	0	lactate	84,91	phosphoglucose_isomerase	267,291	lactate	phosphoglucose isomerase	MESH:D019344	2821	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	-LSB- Enzymatic activities of retina and anthocyanoside extracts of Vaccinium myrtillus -LRB- lactate dehydrogenase , alpha-hydroxybutyrate dehydrogenase , 6-phosphogluconate dehydrogenase , glucose-6-phosphate_dehydrogenase , alpha-glycerophosphate dehydrogenase , 5-nucleotidase , phosphoglucose_isomerase -RRB- -RSB- .
4679830	0	lactate	29,36	phospholipase_A	10,25	lactate	phospholipase A	MESH:D019344	57110	Chemical	Gene	production|amod|START_ENTITY Effect|nmod|production Effect|nmod|END_ENTITY	Effect of phospholipase_A on lactate production by leukocytes from diabetic subjects .
7950293	0	lactate	44,51	platelet_factor_4	67,84	lactate	platelet factor 4	MESH:D019344	5196	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	Influence of Pall Pl-50 platelet filters on lactate dehydrogenase , platelet_factor_4 , and complement factor 3 in stored platelet concentrates .
25016713	0	lactate	6,13	prostate_specific_antigen	68,93	lactate	prostate specific antigen	MESH:D019344	354	Chemical	Gene	START_ENTITY|nmod|ratio ratio|compound|END_ENTITY	Serum lactate dehydrogenase in combination with free-to-total serum prostate_specific_antigen ratio for diagnosis of prostate_cancer .
15322102	0	lactate	74,81	slc5a8	14,20	lactate	slc5a8	MESH:D019344	160728	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of slc5a8 in kidney and its role in Na -LRB- + -RRB- - coupled transport of lactate .
14767771	0	lactate	71,78	troponin-I	31,41	lactate	troponin-I	MESH:D019344	29248(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY END_ENTITY|nmod|release	Partial and delayed release of troponin-I compared with the release of lactate dehydrogenase from necrotic cardiomyocytes .
16983936	0	lactate	158,165	vascular_endothelial_growth_factor	14,48	lactate	vascular endothelial growth factor	MESH:D019344	7422	Chemical	Gene	dehydrogenase|nmod|START_ENTITY dehydrogenase|nsubj|Expression Expression|nmod|END_ENTITY	Expression of vascular_endothelial_growth_factor , fibroblast growth factor , and lactate dehydrogenase by human peritoneal mesothelial cells in solutions with lactate or bicarbonate or both .
23033288	0	lactate	66,73	vascular_endothelial_growth_factor	30,64	lactate	vascular endothelial growth factor	MESH:D019344	7422	Chemical	Gene	START_ENTITY|nsubj|Significance Significance|appos|END_ENTITY	Significance of tumor burden , vascular_endothelial_growth_factor , lactate dehydrogenase and beta-2_microglobulin serum levels in advanced diffuse_large_B_cell lymphoma .
21131367	0	lactic_acid	78,89	IL-17A	57,63	lactic acid	IL-17A	MESH:D019344	3605	Chemical	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	IL-23-dependent and - independent enhancement pathways of IL-17A production by lactic_acid .
2327250	0	lactic_acid	19,30	neuron-specific_enolase	48,71	lactic acid	neuron-specific enolase	MESH:D019344	2026	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Contrary effect of lactic_acid on expression of neuron-specific_enolase and glial_fibrillary_acidic_protein in human glioma cells .
22906018	0	lactic_acid	13,24	vascular_endothelial_growth_factor	55,89	lactic acid	vascular endothelial growth factor	MESH:D019344	83785(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Influence of lactic_acid on differential expression of vascular_endothelial_growth_factor and pigment_epithelium-derived_factor in explants of rat retina .
23313877	0	lactoferricin	7,20	TIMP-3	29,35	lactoferricin	TIMP-3	null	7078	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Bovine lactoferricin induces TIMP-3 via the ERK1/2-Sp 1 axis in human articular chondrocytes .
11083760	0	lactoferrin	6,17	CD14	41,45	lactoferrin	CD14	null	929	Chemical	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Human lactoferrin interacts with soluble CD14 and inhibits expression of endothelial adhesion molecules , E-selectin and ICAM-1 , induced by the CD14-lipopolysaccharide complex .
12825623	0	lactoferrin	37,48	HE-3b	65,70	lactoferrin	HE-3b	null	64184	Chemical	Gene	interaction|nmod|START_ENTITY END_ENTITY|nmod|interaction	On the molecular interaction between lactoferrin and the dye Red HE-3b .
10483875	0	lactoferrin	22,33	LFA-1	60,65	lactoferrin	LFA-1	null	3683	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|compound|END_ENTITY	Regulatory effects of lactoferrin and lipopolysaccharide on LFA-1 expression on human peripheral blood mononuclear cells .
15041480	0	lactoferrin	69,80	MG2	58,61	lactoferrin	MG2	null	4589	Chemical	Gene	protein|dep|START_ENTITY protein|compound|END_ENTITY	Salivary micelles : identification of complexes containing MG2 , sIgA , lactoferrin , amylase , glycosylated proline-rich protein and lysozyme .
9363766	0	lactoferrin	29,40	Transferrin	0,11	lactoferrin	Transferrin	null	7018	Chemical	Gene	interactions|nmod|START_ENTITY END_ENTITY|dep|interactions	Transferrin -- interactions of lactoferrin with hydrogen_carbonate .
22292499	0	lactoferrin	110,121	glyceraldehyde-3-phosphate_dehydrogenase	39,79	lactoferrin	glyceraldehyde-3-phosphate dehydrogenase	null	2597	Chemical	Gene	receptor|compound|START_ENTITY receptor|nsubj|END_ENTITY	The multifunctional glycolytic protein glyceraldehyde-3-phosphate_dehydrogenase -LRB- GAPDH -RRB- is a novel macrophage lactoferrin receptor .
9930659	0	lactoferrin	66,77	heparan_sulphate_proteoglycans	8,38	lactoferrin	heparan sulphate proteoglycans	null	6383	Chemical	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Role of heparan_sulphate_proteoglycans in the regulation of human lactoferrin binding and activity in the MDA-MB-231_breast_cancer cell line .
22226679	0	lactoferrin	6,17	intercellular_adhesion_molecule-1	43,76	lactoferrin	intercellular adhesion molecule-1	null	3383	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Human lactoferrin suppresses TNF-a-induced intercellular_adhesion_molecule-1 expression via competition with NF-kB in endothelial cells .
4673983	0	lactoferrin	15,26	lysozyme	32,40	lactoferrin	lysozyme	null	4069	Chemical	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of lactoferrin with lysozyme in granules of human polymorphonuclear leukocytes .
2827814	0	lactoferrin	31,42	myeloperoxidase	97,112	lactoferrin	myeloperoxidase	null	4353	Chemical	Gene	Biosynthesis|nmod|START_ENTITY Biosynthesis|nmod|END_ENTITY	Biosynthesis and processing of lactoferrin in bone marrow cells , a comparison with processing of myeloperoxidase .
10024604	0	lactoferrin	72,83	orf3	93,97	lactoferrin	orf3	null	6779344(Tax:480)	Chemical	Gene	mutants|compound|START_ENTITY mutants|amod|END_ENTITY	Characterization of Moraxella -LRB- Branhamella -RRB- _ catarrhalis lbpB , lbpA , and lactoferrin receptor orf3 isogenic mutants .
16809317	0	lactoferrin	13,24	tax	122,125	lactoferrin	tax	null	1491938(Tax:11908)	Chemical	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|nmod|END_ENTITY	Induction of lactoferrin gene expression in myeloid or mammary gland cells by human_T-cell_leukemia_virus_type_1 _ -LRB- HTLV-1 -RRB- tax : implications for milk-borne transmission of HTLV-1 .
6469273	0	lactoferrin	10,21	transferrin	95,106	lactoferrin	transferrin	null	7018	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|comparison comparison|nmod|END_ENTITY	Effect of lactoferrin on the growth of a human colon_adenocarcinoma cell line -- comparison with transferrin .
20368037	0	lactoferrin	12,23	vascular_endothelial_growth_factor	27,61	lactoferrin	vascular endothelial growth factor	null	7422	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	-LSB- Effects of lactoferrin on vascular_endothelial_growth_factor and basic_fibroblast_growth_factor expression in human Tca8113 cell line -RSB- .
4757501	0	lactogen	16,24	HPL	26,29	lactogen	HPL	null	3956	Chemical	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Human placental lactogen -LRB- HPL -RRB- levels in maternal serum during abortion induced by intra - and extra-amniotic injection of prostaglandin_F2a .
843477	0	lactogen	36,44	HPL	46,49	lactogen	HPL	null	3956	Chemical	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Effects of noise on human placental lactogen -LRB- HPL -RRB- levels in maternal plasma .
1709896	0	lactogens	93,102	growth_hormone	36,50	lactogens	growth hormone	null	2688	Chemical	Gene	levels|nmod|START_ENTITY END_ENTITY|nmod|levels	Serum levels and molecular sizes of growth_hormone during pregnancy in relation to levels of lactogens , insulin-like_growth_factor_I and insulin-like growth factor binding protein-1 .
20848775	0	lactone	80,87	GluR5	25,30	lactone	GluR5	CHEBI:25000	29559(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|expression expression|nmod|END_ENTITY	-LSB- Different expression of GluR5 and GluR6 in rat astrocyte induced with coriaria lactone and ATPA -RSB- .
10064573	0	lactone	51,58	cyclooxygenase-2	59,75	lactone	cyclooxygenase-2	CHEBI:25000	29527(Tax:10116)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Oxidative bioactivation of the lactol prodrug of a lactone cyclooxygenase-2 inhibitor .
8020591	0	lactose	14,21	CBP35	33,38	lactose	CBP35	MESH:D007785	3958	Chemical	Gene	START_ENTITY|xcomp|binding binding|nmod|END_ENTITY	Evidence that lactose binding to CBP35 disrupts its interaction with CBP70 in isolated HL60 cell nuclei .
7356016	0	lactose	42,49	Prolactin	0,9	lactose	Prolactin	MESH:D007785	5617	Chemical	Gene	correlation|nmod|START_ENTITY END_ENTITY|dep|correlation	Prolactin in human milk : correlation with lactose , total protein , and alpha-lactalbumin levels .
18600962	0	lactose	14,21	beta-galactosidase	50,68	lactose	beta-galactosidase	MESH:D007785	2720	Chemical	Gene	Hydrolysis|nmod|START_ENTITY Hydrolysis|nmod|END_ENTITY	Hydrolysis of lactose in skim milk by immobilized beta-galactosidase -LRB- bacillus circulans -RRB- .
430254	0	lactose	10,17	calcium-binding_protein	30,53	lactose	calcium-binding protein	MESH:D007785	29177(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of lactose on duodenal calcium-binding_protein and calcium absorption .
8806604	0	lactose	36,43	cholera_toxin_B_subunit	77,100	lactose	cholera toxin B subunit	MESH:D007785	9468	Chemical	Gene	analysis|nmod|START_ENTITY analysis|nmod|END_ENTITY	Fluorescence analysis of galactose , lactose , and fucose interaction with the cholera_toxin_B_subunit .
19641853	0	lactose	36,43	galectin-3	94,104	lactose	galectin-3	MESH:D007785	3958	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Conformational entropy changes upon lactose binding to the carbohydrate recognition domain of galectin-3 .
12712706	0	lactose	50,57	lactase	21,28	lactose	lactase	MESH:D007785	3938	Chemical	Gene	absorption|nmod|START_ENTITY END_ENTITY|nmod|absorption	-LSB- Effect of exogenous lactase on the absorption of lactose and its intolerance symptoms -RSB- .
407024	0	lactose	22,29	lactase	52,59	lactose	lactase	MESH:D007785	100625897	Chemical	Gene	START_ENTITY|nmod|development development|nmod|activity activity|amod|END_ENTITY	-LSB- Influence of dietary lactose on the development of lactase activity in the digestive tract of the pig -RSB- .
8351284	0	lactose	68,75	prolactin	43,52	lactose	prolactin	MESH:D007785	5617	Chemical	Gene	synthesis|amod|START_ENTITY stimulation|nmod|synthesis stimulation|compound|END_ENTITY	Effects of cholera and pertussis toxins on prolactin stimulation of lactose synthesis and ornithine_decarboxylase activity in mouse mammary gland explants .
10350470	0	lactose	56,63	repressor	64,73	lactose	repressor	MESH:D007785	3722458(Tax:562)	Chemical	Gene	protein|amod|START_ENTITY protein|compound|END_ENTITY	Thermodynamic analysis of unfolding and dissociation in lactose repressor protein .
2703485	0	lactose	28,35	repressor	36,45	lactose	repressor	MESH:D007785	3722458(Tax:562)	Chemical	Gene	protein|amod|START_ENTITY protein|compound|END_ENTITY	Mutation in hinge region of lactose repressor protein alters physical and functional properties .
2968118	0	lactose	40,47	repressor	48,57	lactose	repressor	MESH:D007785	3722458(Tax:562)	Chemical	Gene	protein|amod|START_ENTITY protein|compound|END_ENTITY	Diethyl_pyrocarbonate reaction with the lactose repressor protein affects both inducer and DNA binding .
765339	0	lactose	38,45	repressor	46,55	lactose	repressor	MESH:D007785	3722458(Tax:562)	Chemical	Gene	START_ENTITY|dobj|protein protein|compound|END_ENTITY	Kinetic studies of inducer binding to lactose repressor protein .
21318225	0	lactosylceramide	16,32	P-glycoprotein	74,88	lactosylceramide	P-glycoprotein	MESH:C009744	5243	Chemical	Gene	Accumulation|nmod|START_ENTITY Accumulation|nmod|END_ENTITY	Accumulation of lactosylceramide and overexpression of a PSC833-resistant P-glycoprotein in multidrug-resistant human sarcoma cells .
812551	0	lactosylceramide	24,40	beta-galactosidase	41,59	lactosylceramide	beta-galactosidase	MESH:C009744	2720	Chemical	Gene	activities|amod|START_ENTITY activities|amod|END_ENTITY	Effect of bile_salts on lactosylceramide beta-galactosidase activities in human brain , liver and cultured skin fibroblasts .
15229242	0	lactosylceramide	16,32	inducible_nitric_oxide_synthase	99,130	lactosylceramide	inducible nitric oxide synthase	MESH:C009744	24599(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|regulation regulation|nmod|expression expression|compound|END_ENTITY	A novel role of lactosylceramide in the regulation of lipopolysaccharide/interferon-gamma-mediated inducible_nitric_oxide_synthase gene expression : implications for neuroinflammatory_diseases .
7115318	0	lactoyl-pepstatin	15,32	cathepsin_D	73,84	lactoyl-pepstatin	cathepsin D	MESH:C035626	494568(Tax:9823)	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nsubj|effects	The effects of lactoyl-pepstatin and the pepsin inhibitor peptide on pig cathepsin_D .
14594250	0	lactulose	104,113	C-reactive_protein	0,18	lactulose	C-reactive protein	MESH:D007792	527553(Tax:9913)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	C-reactive_protein and antibacterial activity in blood plasma of colostrum-fed calves and the effect of lactulose .
8844720	0	lactulose	14,23	DMH	49,52	lactulose	DMH	MESH:D007792	667	Chemical	Gene	effect|nmod|START_ENTITY induced|nsubj|effect induced|nmod|END_ENTITY	The effect of lactulose on DNA damage induced by DMH in the colon of human flora-associated rats .
24817288	0	lactuside_B	13,24	AQP4	46,50	lactuside B	AQP4	MESH:C581344	25293(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Influence of lactuside_B on the expression of AQP4 and TRPM7 mRNAs in the cerebral cortex after cerebral_ischemia_injury .
24862938	0	ladostigil	93,103	monoamine_oxidase	123,140	ladostigil	monoamine oxidase	MESH:C423264	29253(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Functional connectivity in prenatally stressed rats with and without maternal treatment with ladostigil , a brain-selective monoamine_oxidase inhibitor .
16882104	0	lafutidine	93,103	Calcitonin_gene-related_peptide	0,31	lafutidine	Calcitonin gene-related peptide	MESH:C076948	796	Chemical	Gene	curve|amod|START_ENTITY correlated|nmod|curve correlated|nsubj|releases releases|compound|END_ENTITY	Calcitonin_gene-related_peptide and somatostatin releases correlated with the area under the lafutidine concentration-time curve in human plasma .
21115820	3	lamellipodin	610,622	profilin1	579,588	lamellipodin	profilin1	null	5216	Chemical	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	In this study , we show that profilin1 negatively regulates lamellipodin targeting to the leading edge in MDA-MB-231 breast_cancer cells and normal cells ; profilin1 depletion increases lamellipodin concentration at the lamellipodial tip -LRB- where it binds Ena/VASP -RRB- , and this mediates the hypermotility .
22397592	0	laminarin	10,19	GRP78	41,46	laminarin	GRP78	MESH:C008247	25617(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	Effect of laminarin on the expression of GRP78 and GRP94 in rat after unilateral_ureteral_obstruction .
20608352	0	laminarin_sulphate	12,30	PTEN	53,57	laminarin sulphate	PTEN	null	5728	Chemical	Gene	START_ENTITY|nmod|expressions expressions|nmod|END_ENTITY	-LSB- Effects of laminarin_sulphate on the expressions of PTEN and P271kip1 in prostate_cancer PC-3 cells -RSB- .
9720496	0	laminin	33,40	Cathepsin_B	0,11	laminin	Cathepsin B	null	1508	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Cathepsin_B and tumor-associated laminin expression in the progression of colorectal_adenoma_to_carcinoma .
16391810	0	laminin	35,42	FAK	19,22	laminin	FAK	null	5747	Chemical	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|nmod|END_ENTITY	Down-regulation of FAK and IAPs by laminin during cisplatin-induced apoptosis in testicular_germ_cell_tumors .
23823499	4	laminin	503,510	LRP	531,534	laminin	LRP	null	3921	Chemical	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Western blot analysis revealed a significant increase in total laminin receptor precursor -LRB- LRP -RRB- levels of breast_and_oesophageal_cancer cells in comparison to non-invasive MCF-7 breast_cancer cells , whereas LRP/LR cell surface levels in both cell lines were not significantly different to those of MCF-7 cells as analysed by flow cytometry .
21321942	0	laminin-111	8,19	neurotrophin-3	23,37	laminin-111	neurotrophin-3	null	4908	Chemical	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Role of laminin-111 in neurotrophin-3 production of canine adipose-derived stem cells : involvement of Akt , mTOR , and p70S6K .
10840180	1	lamivudine	74,84	CD-1	94,98	lamivudine	CD-1	MESH:D019259	111334(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|mice mice|compound|END_ENTITY	long-term neurobehavioral effects of lamivudine -LRB- 3TC -RRB- in CD-1 mice .
22875535	0	lamivudine	72,82	CD4	86,89	lamivudine	CD4	MESH:D019259	920	Chemical	Gene	START_ENTITY|nmod|cells cells|nummod|END_ENTITY	Organic cation transporters OCT1 and OCT2 determine the accumulation of lamivudine in CD4 cells of HIV-infected patients .
17876158	0	lamivudine	79,89	CHOP	57,61	lamivudine	CHOP	MESH:D019259	1649	Chemical	Gene	administration|compound|START_ENTITY END_ENTITY|nmod|administration	-LSB- Reactivation of hepatitis_B_virus due to rituximab plus CHOP after preemptive lamivudine administration in a patient with diffuse large B-cell_lymphoma -RSB- .
16476009	0	lamivudine	54,64	Serotonin_transporter	0,21	lamivudine	Serotonin transporter	MESH:D019259	6532	Chemical	Gene	decreased|nmod|START_ENTITY decreased|nsubjpass|expression expression|amod|END_ENTITY	Serotonin_transporter mRNA expression is decreased by lamivudine and ribavirin and increased by interferon in immune cells .
23615131	0	lamivudine	63,73	a-2a	38,42	lamivudine	a-2a	MESH:D019259	28882	Chemical	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	Extended treatment with peginterferon a-2a in combination with lamivudine or adefovir for 96 weeks yields high rates of HBeAg and HBsAg seroconversion .
22826629	0	lamivudine	82,92	interferon-y	10,22	lamivudine	interferon-y	MESH:D019259	3458	Chemical	Gene	treatment|amod|START_ENTITY Effect|nmod|treatment Effect|nmod|END_ENTITY	Effect of interferon-y and tumor_necrosis_factor-a on hepatitis_B_virus following lamivudine treatment .
14560155	0	lamivudine	111,121	pituitary_adenylate_cyclase_activating_polypeptide	7,57	lamivudine	pituitary adenylate cyclase activating polypeptide	MESH:D019259	116	Chemical	Gene	treatment|amod|START_ENTITY END_ENTITY|nmod|treatment	Plasma pituitary_adenylate_cyclase_activating_polypeptide -LRB- PACAP -RRB- levels in chronic hepatitis_B patients under lamivudine treatment .
25645391	0	lamotrigine	23,34	breast_cancer_resistance_protein	69,101	lamotrigine	breast cancer resistance protein	MESH:C047781	9429	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	The antiepileptic drug lamotrigine is a substrate of mouse and human breast_cancer_resistance_protein -LRB- ABCG2 -RRB- .
18423830	0	lamotrigine	14,25	monoamine_oxidase_type_B	38,62	lamotrigine	monoamine oxidase type B	MESH:C047781	4129	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|compound|END_ENTITY	The effect of lamotrigine on platelet monoamine_oxidase_type_B activity in patients with bipolar_depression .
17331932	0	landiolol	12,21	c-Fos	54,59	landiolol	c-Fos	MESH:C077049	14281(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Intrathecal landiolol inhibits nociception and spinal c-Fos expression in the mouse formalin test .
20145259	0	laninamivir	29,40	neuraminidase	62,75	laninamivir	neuraminidase	MESH:C546918	4758	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY pharmacokinetics|appos|inhibitor inhibitor|compound|END_ENTITY	Clinical pharmacokinetics of laninamivir , a novel long-acting neuraminidase inhibitor , after single and multiple inhaled doses of its prodrug , CS-8958 , in healthy male volunteers .
22526307	0	laninamivir_octanoate	146,167	neuraminidase	67,80	laninamivir octanoate	neuraminidase	MESH:C546918	4758	Chemical	Gene	distribution|appos|START_ENTITY distribution|appos|inhibitor inhibitor|amod|END_ENTITY	Intrapulmonary distribution and pharmacokinetics of laninamivir , a neuraminidase inhibitor , after a single inhaled administration of its prodrug , laninamivir_octanoate , in healthy volunteers .
24682756	0	laninamivir_octanoate	70,91	neuraminidase	107,120	laninamivir octanoate	neuraminidase	MESH:C546918	4758	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Identification of bioactivating enzymes involved in the hydrolysis of laninamivir_octanoate , a long-acting neuraminidase inhibitor , in human pulmonary tissue .
10777820	0	lanoconazole	24,36	TNF	101,104	lanoconazole	TNF	MESH:C072774	21926(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	-LSB- Suppressive effects of lanoconazole on arthus phenomenon in vivo and on production and functions of TNF in vitro -RSB- .
14630712	0	lanosterol	29,39	CYP51	61,66	lanosterol	CYP51	MESH:D007810	13121(Tax:10090)	Chemical	Gene	enzyme|compound|START_ENTITY enzyme|compound|END_ENTITY	A functional cytochrome P450 lanosterol 14 alpha-demethylase CYP51 enzyme in the acrosome : transport through the Golgi and synthesis of meiosis-activating sterols .
3335544	0	lanosterol	43,53	demethylase	70,81	lanosterol	demethylase	MESH:D007810	8932	Chemical	Gene	START_ENTITY|dobj|activity activity|compound|END_ENTITY	A mammalian mutant cell lacking detectable lanosterol 14 alpha-methyl demethylase activity .
10469005	0	lanreotide	16,26	LAR	42,45	lanreotide	LAR	MESH:C060347	5792	Chemical	Gene	comparison|nmod|START_ENTITY END_ENTITY|nsubj|comparison	A comparison of lanreotide and octreotide LAR for treatment of acromegaly .
10822218	0	lanreotide	85,95	growth_hormone	9,23	lanreotide	growth hormone	MESH:C060347	2688	Chemical	Gene	START_ENTITY|nsubj|profiles profiles|compound|END_ENTITY	Variable growth_hormone profiles following withdrawal of long-term 30mg slow-release lanreotide treatment in acromegalic patients : clinical implications .
12527855	0	lanreotide	11,21	prolactin	25,34	lanreotide	prolactin	MESH:C060347	5617	Chemical	Gene	START_ENTITY|nmod|level level|compound|END_ENTITY	-LSB- Effect of lanreotide on prolactin level in patients with pituitary_mixed_tumors -RSB- .
10391666	0	lansoprazole	49,61	CYP2C19	65,72	lansoprazole	CYP2C19	MESH:C058687	1557	Chemical	Gene	START_ENTITY|nmod|metabolizers metabolizers|nummod|END_ENTITY	Theophylline pharmacokinetics are not altered by lansoprazole in CYP2C19 poor metabolizers .
11821750	0	lansoprazole	11,23	CYP2C19	117,124	lansoprazole	CYP2C19	MESH:C058687	1557	Chemical	Gene	Effects|nmod|START_ENTITY Effects|dep|case case|nmod|recipient recipient|nmod|mutation mutation|compound|END_ENTITY	Effects of lansoprazole and rabeprazole on tacrolimus blood concentration : case of a renal transplant recipient with CYP2C19 gene mutation .
11929404	0	lansoprazole	14,26	CYP2C19	117,124	lansoprazole	CYP2C19	MESH:C058687	1557	Chemical	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|groups groups|compound|END_ENTITY	Comparison of lansoprazole and famotidine for gastric acid inhibition during the daytime and night-time in different CYP2C19 genotype groups .
12152007	0	lansoprazole	32,44	CYP2C19	83,90	lansoprazole	CYP2C19	MESH:C058687	1557	Chemical	Gene	disposition|nmod|START_ENTITY disposition|nmod|END_ENTITY	Enantioselective disposition of lansoprazole in extensive and poor metabolizers of CYP2C19 .
15285851	0	lansoprazole	10,22	CYP2C19	97,104	lansoprazole	CYP2C19	MESH:C058687	1557	Chemical	Gene	Effect|nmod|START_ENTITY pharmacokinetics|nsubj|Effect pharmacokinetics|nmod|mutations mutations|nummod|END_ENTITY	Effect of lansoprazole and rabeprazole on tacrolimus pharmacokinetics in healthy volunteers with CYP2C19 mutations .
15301728	0	lansoprazole	20,32	CYP2C19	76,83	lansoprazole	CYP2C19	MESH:C058687	1557	Chemical	Gene	START_ENTITY|nmod|subjects subjects|nmod|relation relation|nmod|END_ENTITY	Pharmacokinetics of lansoprazole in Chinese healthy subjects in relation to CYP2C19 genotypes .
15496639	0	lansoprazole	26,38	CYP2C19	71,78	lansoprazole	CYP2C19	MESH:C058687	1557	Chemical	Gene	fluvoxamine|nmod|START_ENTITY Effects|nmod|fluvoxamine pharmacokinetics|nsubj|Effects pharmacokinetics|nmod|genotypes genotypes|nummod|END_ENTITY	Effects of fluvoxamine on lansoprazole pharmacokinetics in relation to CYP2C19 genotypes .
15664363	0	lansoprazole	17,29	CYP2C19	181,188	lansoprazole	CYP2C19	MESH:C058687	1557	Chemical	Gene	Determination|nmod|START_ENTITY Determination|dep|application application|acl|measuring measuring|dobj|activity activity|compound|END_ENTITY	Determination of lansoprazole and two of its metabolites by liquid-liquid extraction and automated column-switching high-performance liquid chromatography : application to measuring CYP2C19 activity .
15752376	0	lansoprazole	29,41	CYP2C19	67,74	lansoprazole	CYP2C19	MESH:C058687	1557	Chemical	Gene	pharmacokinetics|amod|START_ENTITY pharmacokinetics|nmod|END_ENTITY	Effects of clarithromycin on lansoprazole pharmacokinetics between CYP2C19 genotypes .
15856433	0	lansoprazole	64,76	CYP2C19	92,99	lansoprazole	CYP2C19	MESH:C058687	1557	Chemical	Gene	START_ENTITY|nmod|relation relation|nmod|END_ENTITY	Effect of clarithromycin on the enantioselective disposition of lansoprazole in relation to CYP2C19 genotypes .
15963082	0	lansoprazole	48,60	CYP2C19	102,109	lansoprazole	CYP2C19	MESH:C058687	1557	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|status status|compound|END_ENTITY	Effect of concomitant dosing of famotidine with lansoprazole on gastric_acid secretion in relation to CYP2C19 genotype status .
15963095	0	lansoprazole	32,44	CYP2C19	60,67	lansoprazole	CYP2C19	MESH:C058687	1557	Chemical	Gene	START_ENTITY|nmod|relation relation|nmod|END_ENTITY	Enantioselective disposition of lansoprazole in relation to CYP2C19 genotypes in the presence of fluvoxamine .
16012079	0	lansoprazole	65,77	CYP2C19	117,124	lansoprazole	CYP2C19	MESH:C058687	1557	Chemical	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|recipients recipients|acl:relcl|END_ENTITY	Comparison of enantioselective disposition of rabeprazole versus lansoprazole in renal-transplant recipients who are CYP2C19 extensive metabolizers .
16487234	0	lansoprazole	17,29	CYP2C19	54,61	lansoprazole	CYP2C19	MESH:C058687	1557	Chemical	Gene	Hydroxylation|nmod|START_ENTITY Hydroxylation|nmod|END_ENTITY	Hydroxylation of lansoprazole in poor metabolizers of CYP2C19 .
17190370	0	lansoprazole	66,78	CYP2C19	163,170	lansoprazole	CYP2C19	MESH:C058687	1557	Chemical	Gene	symptoms|amod|START_ENTITY pharmacokinetics|nmod|symptoms polymorphism|nmod|pharmacokinetics Influence|nmod|polymorphism classified|nsubj|Influence classified|nmod|metabolizers metabolizers|nummod|END_ENTITY	Influence of ABCB1 C3435T polymorphism on the pharmacokinetics of lansoprazole and gastroesophageal symptoms in Japanese renal transplant recipients classified as CYP2C19 extensive metabolizers and treated with tacrolimus .
17358097	0	lansoprazole	80,92	CYP2C19	108,115	lansoprazole	CYP2C19	MESH:C058687	1557	Chemical	Gene	enantiomers|amod|START_ENTITY enantiomers|nmod|recipients recipients|nummod|END_ENTITY	Influence of cytochrome P450 -LRB- CYP -RRB- 3A5 polymorphisms on the pharmacokinetics of lansoprazole enantiomers in CYP2C19 extensive metaboliser renal transplant recipients .
18445994	0	lansoprazole	35,47	CYP2C19	127,134	lansoprazole	CYP2C19	MESH:C058687	1557	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|defects defects|nmod|END_ENTITY	Interaction between tacrolimus and lansoprazole , but not rabeprazole in living-donor liver transplant patients with defects of CYP2C19 and CYP3A5 .
19259653	0	lansoprazole	108,120	CYP2C19	0,7	lansoprazole	CYP2C19	MESH:C058687	1557	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|genotype genotype|compound|END_ENTITY	CYP2C19 genotype is associated with symptomatic recurrence of GERD during maintenance therapy with low-dose lansoprazole .
19459830	0	lansoprazole	101,113	CYP2C19	42,49	lansoprazole	CYP2C19	MESH:C058687	1557	Chemical	Gene	inhibitor|appos|START_ENTITY phenotype|nmod|inhibitor phenotype|compound|END_ENTITY	-LSB- 13C -RSB- - pantoprazole breath test to predict CYP2C19 phenotype and efficacy of a proton pump inhibitor , lansoprazole .
20528170	0	lansoprazole	73,85	CYP2C19	13,20	lansoprazole	CYP2C19	MESH:C058687	1557	Chemical	Gene	enantiomers|amod|START_ENTITY concentrations|nmod|enantiomers polymorphisms|nmod|concentrations polymorphisms|nsubj|Influence Influence|nmod|END_ENTITY	Influence of CYP2C19 and ABCB1 polymorphisms on plasma concentrations of lansoprazole enantiomers after enteral administration .
20673183	0	lansoprazole	54,66	CYP2C19	14,21	lansoprazole	CYP2C19	MESH:C058687	1557	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY effect|nmod|pharmacokinetics effect|nmod|activity activity|compound|END_ENTITY	The effect of CYP2C19 activity on pharmacokinetics of lansoprazole and its active metabolites in healthy subjects .
21521077	0	lansoprazole	59,71	CYP2C19	11,18	lansoprazole	CYP2C19	MESH:C058687	1557	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY polymorphism|nmod|pharmacokinetics polymorphism|nsubj|Effects Effects|nmod|END_ENTITY	Effects of CYP2C19 polymorphism on the pharmacokinetics of lansoprazole and its main metabolites in healthy Chinese subjects .
21769476	0	lansoprazole	152,164	CYP2C19	24,31	lansoprazole	CYP2C19	MESH:C058687	1557	Chemical	Gene	influence|nmod|START_ENTITY polymorphism|dep|influence polymorphism|nmod|END_ENTITY	Genetic polymorphism of CYP2C19 in a Jordanian population : influence of allele frequencies of CYP2C19 * 1 and CYP2C19 * 2 on the pharmacokinetic profile of lansoprazole .
21769476	0	lansoprazole	152,164	CYP2C19	94,101	lansoprazole	CYP2C19	MESH:C058687	1557	Chemical	Gene	influence|nmod|START_ENTITY influence|nmod|frequencies frequencies|nmod|END_ENTITY	Genetic polymorphism of CYP2C19 in a Jordanian population : influence of allele frequencies of CYP2C19 * 1 and CYP2C19 * 2 on the pharmacokinetic profile of lansoprazole .
24022708	0	lansoprazole	101,113	CYP2C19	40,47	lansoprazole	CYP2C19	MESH:C058687	1557	Chemical	Gene	study|nmod|START_ENTITY study|nmod|C3435T C3435T|compound|END_ENTITY	A correlative study of polymorphisms of CYP2C19 and MDR1 C3435T with the pharmacokinetic profiles of lansoprazole and its main metabolites following single oral administration in healthy adult Chinese subjects .
25109411	0	lansoprazole	92,104	CYP2C19	36,43	lansoprazole	CYP2C19	MESH:C058687	1557	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY Effects|nmod|pharmacokinetics Effects|nmod|polymorphisms polymorphisms|nmod|2 2|advmod|END_ENTITY	Effects of genetic polymorphisms of CYP2C19 * 2 / * 3 and MDR1 C3435T on the pharmacokinetics of lansoprazole in healthy Chinese subjects .
11829200	0	lansoprazole	64,76	CYP3A4	8,14	lansoprazole	CYP3A4	MESH:C058687	1576	Chemical	Gene	metabolism|nmod|START_ENTITY Role|nmod|metabolism Role|nmod|END_ENTITY	Role of CYP3A4 and CYP2C19 in the stereoselective metabolism of lansoprazole by human liver microsomes .
20333532	0	lansoprazole	11,23	VEGF	45,49	lansoprazole	VEGF	MESH:C058687	83785(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of lansoprazole on the expression of VEGF and cellular proliferation in a rat model of acetic_acid-induced gastric_ulcer .
11435719	0	lansoprazole	11,23	gastric_lipase	33,47	lansoprazole	gastric lipase	MESH:C058687	8513	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of lansoprazole on human gastric_lipase secretion and intragastric lipolysis in healthy human volunteers .
9190140	0	lansoprazole	36,48	gastrin	73,80	lansoprazole	gastrin	MESH:C058687	2520	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of long-term treatment with lansoprazole and omeprazole on serum gastrin and the fundic mucosa .
19590701	0	lansoprazole	46,58	heme_oxygenase-1	18,34	lansoprazole	heme oxygenase-1	MESH:C058687	24451(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|expression expression|nmod|END_ENTITY	The expression of heme_oxygenase-1 induced by lansoprazole .
8068681	0	lanthanide	24,34	calcineurin-B	61,74	lanthanide	calcineurin-B	CHEBI:33319	5534	Chemical	Gene	properties|amod|START_ENTITY properties|nmod|END_ENTITY	Characterization of the lanthanide ion-binding properties of calcineurin-B using laser-induced luminescence spectroscopy .
15342096	0	lanthanum	86,95	CA1	63,66	lanthanum	CA1	MESH:D007811	310218(Tax:10116)	Chemical	Gene	hippocampal|nmod|START_ENTITY hippocampal|dobj|cells cells|nummod|END_ENTITY	Layer-specific potentiation of evoked IPSCs in rat hippocampal CA1 pyramidal cells by lanthanum .
23831939	0	lanthanum	32,41	Spin	0,4	lanthanum	Spin	MESH:D007811	10927	Chemical	Gene	injection|nmod|START_ENTITY injection|compound|END_ENTITY	Spin injection and detection in lanthanum - and niobium-doped SrTiO3 using the Hanle technique .
19548582	0	lanthanum	12,21	c-fos	50,55	lanthanum	c-fos	MESH:D007811	314322(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|mRNA mRNA|amod|END_ENTITY	-LSB- Effects of lanthanum on memory and expression of c-fos mRNA and c-Fos protein of cerebral cortex in rats -RSB- .
21695898	0	lanthanum	12,21	cAMP_response_element_binding_protein	48,85	lanthanum	cAMP response element binding protein	MESH:D007811	81646(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	-LSB- Effects of lanthanum on the phosphorylation of cAMP_response_element_binding_protein and expression of immediate early genes in the hippocampal CA3 area of rats -RSB- .
1077784	0	lanthanum	29,38	renin	12,17	lanthanum	renin	MESH:D007811	24715(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|Blockade Blockade|nmod|END_ENTITY	Blockade of renin release by lanthanum .
13401	0	lanthanum	14,23	renin	27,32	lanthanum	renin	MESH:D007811	5972	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|compound|END_ENTITY	The effect of lanthanum on renin secretion and renal vasoconstriction .
18095553	0	lanthanum_chloride	22,40	inducible_nitric_oxide_synthase	62,93	lanthanum chloride	inducible nitric oxide synthase	MESH:C028521	18126(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	-LSB- Inhibitory effect of lanthanum_chloride on the expression of inducible_nitric_oxide_synthase in RAW264 .7 macrophages induced by lipopolysaccharide -RSB- .
16474884	0	lanthanum_hydroxide	41,60	CO2	24,27	lanthanum hydroxide	CO2	MESH:C033562	717	Chemical	Gene	complex|compound|START_ENTITY END_ENTITY|nmod|complex	Fixation of atmospheric CO2 by a dimeric lanthanum_hydroxide complex ; assembly of an unusual hexameric_carbonate .
21989330	0	lapatinib	70,79	Cyclin_D1	4,13	lapatinib	Cyclin D1	MESH:C490728	595	Chemical	Gene	predicts|nmod|START_ENTITY predicts|nsubj|END_ENTITY	The Cyclin_D1 -LRB- CCND1 -RRB- A870G polymorphism predicts clinical outcome to lapatinib and capecitabine in HER2-positive metastatic breast_cancer .
17635524	0	lapatinib	120,129	EGFR	48,52	lapatinib	EGFR	MESH:C490728	1956	Chemical	Gene	levels|nmod|START_ENTITY protein|dobj|levels protein|nsubj|Assessment Assessment|nmod|epidermal_growth_factor_receptor epidermal_growth_factor_receptor|appos|END_ENTITY	Assessment of epidermal_growth_factor_receptor -LRB- EGFR , ErbB1 -RRB- and HER2 -LRB- ErbB2 -RRB- protein expression levels and response to lapatinib -LRB- Tykerb , GW572016 -RRB- in an expanded panel of human normal and tumour cell lines .
18199554	3	lapatinib	646,655	EGFR	671,675	lapatinib	EGFR	MESH:C490728	1956	Chemical	Gene	s|amod|START_ENTITY effects|nmod|s had|dobj|effects had|advcl|had had|nsubj|L858R L858R|compound|END_ENTITY	The point mutations G719C and L861Q had minor effects on lapatinib K -LRB- i -RRB- s , whereas EGFR mutations L858R and del15 had a higher K -LRB- i -RRB- for lapatinib than wild-type EGFR .
18199554	3	lapatinib	724,733	EGFR	671,675	lapatinib	EGFR	MESH:C490728	1956	Chemical	Gene	K|nmod|START_ENTITY had|dobj|K had|nsubj|L858R L858R|compound|END_ENTITY	The point mutations G719C and L861Q had minor effects on lapatinib K -LRB- i -RRB- s , whereas EGFR mutations L858R and del15 had a higher K -LRB- i -RRB- for lapatinib than wild-type EGFR .
18644997	0	lapatinib	12,21	EGFR	40,44	lapatinib	EGFR	MESH:C490728	1956	Chemical	Gene	Activity|nmod|START_ENTITY independent|nsubj|Activity independent|nmod|level level|amod|END_ENTITY	Activity of lapatinib is independent of EGFR expression level in HER2-overexpressing breast_cancer cells .
18774637	0	lapatinib	32,41	EGFR	63,67	lapatinib	EGFR	MESH:C490728	1956	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	The growth inhibitory effect of lapatinib , a dual inhibitor of EGFR and HER2 tyrosine kinase , in gastric_cancer cell lines .
19309723	0	lapatinib	142,151	EGFR	66,70	lapatinib	EGFR	MESH:C490728	1956	Chemical	Gene	treated|nmod|START_ENTITY malignant_salivary_gland_tumors|acl|treated patients|nmod|malignant_salivary_gland_tumors Fluorescence|nmod|patients Fluorescence|nmod|analysis analysis|nmod|END_ENTITY	Fluorescence in situ hybridization gene amplification analysis of EGFR and HER2 in patients with malignant_salivary_gland_tumors treated with lapatinib .
20204279	0	lapatinib	21,30	EGFR	63,67	lapatinib	EGFR	MESH:C490728	1956	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|inhibitor inhibitor|nmod|END_ENTITY	Antitumor effects of lapatinib -LRB- GW572016 -RRB- , a dual inhibitor of EGFR and HER-2 , in combination with cisplatin or paclitaxel on head_and_neck_squamous_cell_carcinoma .
20459769	0	lapatinib	89,98	EGFR	48,52	lapatinib	EGFR	MESH:C490728	1956	Chemical	Gene	kinase|dobj|START_ENTITY kinase|nsubj|effect effect|nmod|END_ENTITY	Antitumor and antiangiogenic effect of the dual EGFR and HER-2 tyrosine kinase inhibitor lapatinib in a lung_cancer model .
21080629	0	lapatinib	59,68	EGFR	136,140	lapatinib	EGFR	MESH:C490728	1956	Chemical	Gene	hybrides|amod|START_ENTITY hybrides|nmod|inhibitors inhibitors|nmod|epidermal_growth_factor_receptor epidermal_growth_factor_receptor|appos|END_ENTITY	Novel chimeric histone deacetylase inhibitors : a series of lapatinib hybrides as potent inhibitors of epidermal_growth_factor_receptor -LRB- EGFR -RRB- , human epidermal_growth_factor_receptor 2 -LRB- HER2 -RRB- , and histone deacetylase activity .
22745588	6	lapatinib	1001,1010	EGFR	981,985	lapatinib	EGFR	MESH:C490728	1956	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Dual inhibition of EGFR and ERBB2 with lapatinib significantly reduced GBM proliferation in colony formation assays compared to cetuximab-mediated EGFR-specific inhibition .
23375777	0	lapatinib	204,213	EGFR	177,181	lapatinib	EGFR	MESH:C490728	1956	Chemical	Gene	signaling|nmod|START_ENTITY ErbB2|acl|signaling therapeutics|dep|ErbB2 therapeutics|dep|activity activity|nmod|END_ENTITY	Profiling pathway-specific novel therapeutics in preclinical assessment for central nervous system atypical teratoid_rhabdoid_tumors -LRB- CNS ATRT -RRB- : favorable activity of targeting EGFR - ErbB2 signaling with lapatinib .
24044505	8	lapatinib	1744,1753	EGFR	1802,1806	lapatinib	EGFR	MESH:C490728	1956	Chemical	Gene	resistance|nmod|START_ENTITY overcome|dobj|resistance ability|acl|overcome demonstrated|nsubjpass|ability demonstrated|nmod|knockdown knockdown|nmod|END_ENTITY	The ability to overcome EGFR-mediated acquired therapeutic resistance to lapatinib was demonstrated through molecular knockdown of EGFR and treatment with the irreversible pan-HER TKI neratinib , which blocked HRG-dependent phosphorylation of HER3 and EGFR , resulting in apoptosis of resistant cells .
25249538	0	lapatinib	130,139	EGFR	14,18	lapatinib	EGFR	MESH:C490728	13649(Tax:10090)	Chemical	Gene	breast_tumors|nmod|START_ENTITY breast_tumors|nsubj|Activation Activation|nmod|END_ENTITY	Activation of EGFR , HER2 and HER3 by neurotensin/neurotensin _ receptor_1 renders breast_tumors aggressive yet highly responsive to lapatinib and metformin in mice .
25752740	0	lapatinib	100,109	Epidermal_Growth_Factor_Receptor	131,163	lapatinib	Epidermal Growth Factor Receptor	MESH:C490728	1956	Chemical	Gene	trial|nmod|START_ENTITY trial|nmod|END_ENTITY	Health related quality of life of women in TEACH , a randomised placebo controlled adjuvant trial of lapatinib in early stage Human Epidermal_Growth_Factor_Receptor -LRB- HER2 -RRB- overexpressing breast_cancer .
23472669	0	lapatinib	62,71	Epidermal_growth_factor_receptor	0,32	lapatinib	Epidermal growth factor receptor	MESH:C490728	1956	Chemical	Gene	sensitivity|amod|START_ENTITY predict|dobj|sensitivity predict|nsubj|number number|compound|END_ENTITY	Epidermal_growth_factor_receptor gene copy number may predict lapatinib sensitivity in HER2-positive metastatic breast_cancer .
15684311	0	lapatinib	33,42	ErbB1	70,75	lapatinib	ErbB1	MESH:C490728	1956	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Study of the biologic effects of lapatinib , a reversible inhibitor of ErbB1 and ErbB2 tyrosine kinases , on tumor growth and survival pathways in patients with advanced malignancies .
16091755	0	lapatinib	10,19	ErbB1	62,67	lapatinib	ErbB1	MESH:C490728	1956	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Combining lapatinib -LRB- GW572016 -RRB- , a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases , with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast_cancer cells .
17060407	0	lapatinib	84,93	ErbB1	119,124	lapatinib	ErbB1	MESH:C490728	1956	Chemical	Gene	activity|nmod|START_ENTITY evaluation|nmod|activity tomography|nmod|evaluation study|amod|tomography study|appos|inhibitor inhibitor|nmod|END_ENTITY	Prospective study of positron emission tomography for evaluation of the activity of lapatinib , a dual inhibitor of the ErbB1 and ErbB2 tyrosine kinases , in patients with advanced tumors .
17635524	0	lapatinib	120,129	ErbB1	54,59	lapatinib	ErbB1	MESH:C490728	1956	Chemical	Gene	levels|nmod|START_ENTITY protein|dobj|levels protein|nsubj|Assessment Assessment|nmod|epidermal_growth_factor_receptor epidermal_growth_factor_receptor|appos|EGFR EGFR|dep|END_ENTITY	Assessment of epidermal_growth_factor_receptor -LRB- EGFR , ErbB1 -RRB- and HER2 -LRB- ErbB2 -RRB- protein expression levels and response to lapatinib -LRB- Tykerb , GW572016 -RRB- in an expanded panel of human normal and tumour cell lines .
17635524	0	lapatinib	120,129	ErbB2	71,76	lapatinib	ErbB2	MESH:C490728	2064	Chemical	Gene	levels|nmod|START_ENTITY protein|dobj|levels protein|nsubj|Assessment Assessment|nmod|epidermal_growth_factor_receptor epidermal_growth_factor_receptor|appos|END_ENTITY	Assessment of epidermal_growth_factor_receptor -LRB- EGFR , ErbB1 -RRB- and HER2 -LRB- ErbB2 -RRB- protein expression levels and response to lapatinib -LRB- Tykerb , GW572016 -RRB- in an expanded panel of human normal and tumour cell lines .
23375777	0	lapatinib	204,213	ErbB2	183,188	lapatinib	ErbB2	MESH:C490728	2064	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Profiling pathway-specific novel therapeutics in preclinical assessment for central nervous system atypical teratoid_rhabdoid_tumors -LRB- CNS ATRT -RRB- : favorable activity of targeting EGFR - ErbB2 signaling with lapatinib .
18283037	0	lapatinib	150,159	HER2	119,123	lapatinib	HER2	MESH:C490728	2064	Chemical	Gene	START_ENTITY|amod|kinase kinase|nmod|biomarker biomarker|nmod|inhibitor inhibitor|compound|END_ENTITY	Low-scale phosphoproteome analyses identify the mTOR effector p70 S6 kinase 1 as a specific biomarker of the dual-HER1 / HER2 tyrosine kinase inhibitor lapatinib -LRB- Tykerb -RRB- in human breast_carcinoma cells .
18594499	0	lapatinib	72,81	HER2	42,46	lapatinib	HER2	MESH:C490728	2064	Chemical	Gene	development|nmod|START_ENTITY Insight|dep|development Insight|dep|inhibitors inhibitors|nmod|END_ENTITY	Drug Insight : intracellular inhibitors of HER2 -- clinical development of lapatinib in breast_cancer .
19858400	0	lapatinib	102,111	HER2	35,39	lapatinib	HER2	MESH:C490728	2064	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|value value|nmod|extracellular_domain extracellular_domain|nummod|END_ENTITY	Prognostic and predictive value of HER2 extracellular_domain in metastatic_breast_cancer treated with lapatinib and paclitaxel in a randomized phase III study .
20701607	0	lapatinib	20,29	HER2	76,80	lapatinib	HER2	MESH:C490728	2064	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|receptor receptor|appos|END_ENTITY	Combined effects of lapatinib and bortezomib in human epidermal receptor 2 -LRB- HER2 -RRB- - overexpressing breast_cancer cells and activity of bortezomib against lapatinib-resistant breast_cancer cells .
21169261	0	lapatinib	79,88	HER2	31,35	lapatinib	HER2	MESH:C490728	2064	Chemical	Gene	predict|advcl|START_ENTITY predict|nsubj|polysomy polysomy|nmod|amplification amplification|compound|END_ENTITY	Chromosome 17 polysomy without HER2 amplification does not predict response to lapatinib in metastatic breast_cancer -- letter .
21377448	0	lapatinib	127,136	HER2	29,33	lapatinib	HER2	MESH:C490728	2064	Chemical	Gene	failure|amod|START_ENTITY salvage|nmod|failure target|nmod|salvage FGFR2|nmod|target addictions|dep|FGFR2 addictions|nmod|END_ENTITY	Switching addictions between HER2 and FGFR2 in HER2-positive breast_tumor cells : FGFR2 as a potential target for salvage after lapatinib failure .
21406472	0	lapatinib	10,19	HER2	126,130	lapatinib	HER2	MESH:C490728	2064	Chemical	Gene	Impact|nmod|START_ENTITY Impact|nmod|breast_cancer breast_cancer|compound|END_ENTITY	Impact of lapatinib plus trastuzumab versus single-agent lapatinib on quality of life of patients with trastuzumab-refractory HER2 + metastatic breast_cancer .
21406472	0	lapatinib	57,66	HER2	126,130	lapatinib	HER2	MESH:C490728	2064	Chemical	Gene	Impact|nmod|START_ENTITY Impact|nmod|breast_cancer breast_cancer|compound|END_ENTITY	Impact of lapatinib plus trastuzumab versus single-agent lapatinib on quality of life of patients with trastuzumab-refractory HER2 + metastatic breast_cancer .
21456017	0	lapatinib	188,197	HER2	42,46	lapatinib	HER2	MESH:C490728	2064	Chemical	Gene	monotherapy|amod|START_ENTITY receiving|dobj|monotherapy associated|xcomp|receiving extracellular|ccomp|associated extracellular|nsubj|epidermal_growth_factor_receptor_2 epidermal_growth_factor_receptor_2|appos|END_ENTITY	Human epidermal_growth_factor_receptor_2 -LRB- HER2 -RRB- extracellular domain levels are associated with progression-free survival in patients with HER2-positive metastatic_breast_cancer receiving lapatinib monotherapy .
21701940	0	lapatinib	22,31	HER2	64,68	lapatinib	HER2	MESH:C490728	2064	Chemical	Gene	plus|amod|START_ENTITY Cost-effectiveness|nmod|plus capecitabine|nsubj|Cost-effectiveness capecitabine|nmod|women women|nmod|metastatic_breast_cancer metastatic_breast_cancer|compound|END_ENTITY	Cost-effectiveness of lapatinib plus capecitabine in women with HER2 + metastatic_breast_cancer who have received prior therapy with trastuzumab .
21992075	0	lapatinib	163,172	HER2	88,92	lapatinib	HER2	MESH:C490728	2064	Chemical	Gene	+|nmod|START_ENTITY +|nsubj|analysis analysis|nmod|treatment treatment|nmod|END_ENTITY	Quality-adjusted survival analysis of first-line treatment of hormone-receptor-positive HER2 + metastatic breast_cancer with letrozole alone or in combination with lapatinib .
22006161	0	lapatinib	33,42	HER2	106,110	lapatinib	HER2	MESH:C490728	2064	Chemical	Gene	study|nmod|START_ENTITY study|nmod|women women|nmod|breast_cancer breast_cancer|nummod|END_ENTITY	A phase Ib study of preoperative lapatinib , paclitaxel , and gemcitabine combination therapy in women with HER2 positive early breast_cancer .
22240778	0	lapatinib	17,26	HER2	121,125	lapatinib	HER2	MESH:C490728	2064	Chemical	Gene	plus|amod|START_ENTITY study|nmod|plus vinorelbine|nsubj|study vinorelbine|advcl|overexpressing overexpressing|dobj|END_ENTITY	Phase I study of lapatinib plus vinorelbine in patients with locally advanced or metastatic breast_cancer overexpressing HER2 .
22389470	7	lapatinib	1125,1134	HER2	1175,1179	lapatinib	HER2	MESH:C490728	2064	Chemical	Gene	effect|nmod|START_ENTITY weakened|dobj|effect weakened|advcl|indicating indicating|dobj|involvement involvement|nmod|END_ENTITY	Moreover , knocking down of HER2 by an short interfering RNA weakened the effect of lapatinib on ABCB1 , indicating the involvement of HER2 in the inhibitory mechanisms .
22848366	0	lapatinib	74,83	HER2	15,19	lapatinib	HER2	MESH:C490728	2064	Chemical	Gene	outcome|nmod|START_ENTITY Correlation|dep|outcome Correlation|nmod|END_ENTITY	Correlation of HER2 , p95HER2 and HER3 expression and treatment outcome of lapatinib plus capecitabine in her2-positive metastatic breast_cancer .
22892393	0	lapatinib	63,72	HER2	20,24	lapatinib	HER2	MESH:C490728	2064	Chemical	Gene	treated|nmod|START_ENTITY patients|acl|treated levels|nmod|patients levels|nummod|END_ENTITY	Predictive value of HER2 serum levels in patients treated with lapatinib or trastuzumab -- a translational project in the neoadjuvant GeparQuinto trial .
23239151	0	lapatinib	31,40	HER2	89,93	lapatinib	HER2	MESH:C490728	2064	Chemical	Gene	study|nmod|START_ENTITY +|nsubj|study +|nmod|breast_cancer breast_cancer|compound|END_ENTITY	A randomized phase II study of lapatinib + pazopanib versus lapatinib in patients with HER2 + inflammatory breast_cancer .
23239151	0	lapatinib	62,71	HER2	89,93	lapatinib	HER2	MESH:C490728	2064	Chemical	Gene	+|nmod|START_ENTITY +|nmod|breast_cancer breast_cancer|compound|END_ENTITY	A randomized phase II study of lapatinib + pazopanib versus lapatinib in patients with HER2 + inflammatory breast_cancer .
23667487	0	lapatinib	16,25	HER2	59,63	lapatinib	HER2	MESH:C490728	2064	Chemical	Gene	START_ENTITY|nmod|breast_cancer breast_cancer|nmod|primary_tumors primary_tumors|nummod|END_ENTITY	The efficacy of lapatinib in metastatic breast_cancer with HER2 non-amplified primary_tumors and EGFR positive circulating tumor cells : a proof-of-concept study .
23953056	0	lapatinib	61,70	HER2	126,130	lapatinib	HER2	MESH:C490728	2064	Chemical	Gene	START_ENTITY|nmod|therapy therapy|nmod|patients patients|nmod|+ +|compound|END_ENTITY	A phase two randomised trial of neratinib monotherapy versus lapatinib plus capecitabine combination therapy in patients with HER2 + advanced breast_cancer .
23954396	0	lapatinib	18,27	HER2	77,81	lapatinib	HER2	MESH:C490728	2064	Chemical	Gene	study|nmod|START_ENTITY study|nmod|vinorelbine vinorelbine|nmod|patients patients|nmod|recurrent recurrent|compound|END_ENTITY	Phase II study of lapatinib in combination with vinorelbine in patients with HER2 positive recurrent or metastatic breast_cancer : a multicentric Turkish Oncology Group -LRB- TOG -RRB- trial .
24044505	0	lapatinib	69,78	HER2	93,97	lapatinib	HER2	MESH:C490728	2064	Chemical	Gene	resistance|amod|START_ENTITY resistance|nmod|models models|compound|END_ENTITY	An heregulin-EGFR-HER3 autocrine signaling axis can mediate acquired lapatinib resistance in HER2 + breast_cancer models .
24197661	0	lapatinib	19,28	HER2	118,122	lapatinib	HER2	MESH:C490728	2064	Chemical	Gene	START_ENTITY|nmod|radiotherapy radiotherapy|nmod|patients patients|nmod|Human_Epidermal_Growth_Factor_Receptor_2 Human_Epidermal_Growth_Factor_Receptor_2|appos|END_ENTITY	A phase I study of lapatinib with whole brain radiotherapy in patients with Human_Epidermal_Growth_Factor_Receptor_2 -LRB- HER2 -RRB- - positive breast_cancer_brain_metastases .
25186428	0	lapatinib	21,30	HER2	48,52	lapatinib	HER2	MESH:C490728	2064	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|patients patients|nmod|ductal_carcinoma ductal_carcinoma|compound|END_ENTITY	Molecular effects of lapatinib in patients with HER2 positive ductal_carcinoma in situ .
25467182	0	lapatinib	68,77	HER2	5,9	lapatinib	HER2	MESH:C490728	2064	Chemical	Gene	combination|nmod|START_ENTITY correlates|nmod|combination correlates|nsubj|expression expression|compound|END_ENTITY	High HER2 expression correlates with response to the combination of lapatinib and trastuzumab .
25620423	0	lapatinib	88,97	HER2	69,73	lapatinib	HER2	MESH:C490728	2064	Chemical	Gene	resistance|nmod|START_ENTITY resistance|nummod|END_ENTITY	Atomistic insights into the lung_cancer-associated L755P mutation in HER2 resistance to lapatinib : a molecular_dynamics study .
25752740	0	lapatinib	100,109	HER2	165,169	lapatinib	HER2	MESH:C490728	2064	Chemical	Gene	trial|nmod|START_ENTITY trial|appos|END_ENTITY	Health related quality of life of women in TEACH , a randomised placebo controlled adjuvant trial of lapatinib in early stage Human Epidermal_Growth_Factor_Receptor -LRB- HER2 -RRB- overexpressing breast_cancer .
26034656	0	lapatinib	18,27	HER2	107,111	lapatinib	HER2	MESH:C490728	2064	Chemical	Gene	study|nmod|START_ENTITY study|advcl|overexpressing overexpressing|nsubj|therapy therapy|nmod|women women|nmod|END_ENTITY	Phase II study of lapatinib in combination with vinorelbine , as first or second-line therapy in women with HER2 overexpressing metastatic breast_cancer .
26337386	0	lapatinib	93,102	HER2	53,57	lapatinib	HER2	MESH:C490728	13866(Tax:10090)	Chemical	Gene	tyrosine|dobj|START_ENTITY tyrosine|nsubj|responses responses|nmod|receptor receptor|compound|END_ENTITY	Microenvironment_rigidity modulates responses to the HER2 receptor tyrosine kinase inhibitor lapatinib via YAP and TAZ transcription factors .
26710948	0	lapatinib	51,60	HER2	64,68	lapatinib	HER2	MESH:C490728	2064	Chemical	Gene	efficacy|nmod|START_ENTITY correlates|dobj|efficacy correlates|nmod|metastatic_breast_cancer metastatic_breast_cancer|nummod|END_ENTITY	-LSB- PTEN_loss correlates withthe clinical efficacy of lapatinib in HER2 positive metastatic_breast_cancer with trastuzumab-resistance -RSB- .
27026198	0	lapatinib	58,67	HER2	129,133	lapatinib	HER2	MESH:C490728	2064	Chemical	Gene	study|nmod|START_ENTITY followed|nsubj|study followed|nmod|breast_cancer breast_cancer|compound|END_ENTITY	Phase 1 study of an AKT-inhibitor -LRB- MK-2206 -RRB- combined with lapatinib in adult solid tumors followed by dose-expansion in advanced HER2 + breast_cancer .
20607587	0	lapatinib	33,42	P-gp	14,18	lapatinib	P-gp	MESH:C490728	5243	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|expression expression|compound|END_ENTITY	Modulation of P-gp expression by lapatinib .
21415234	0	lapatinib	58,67	S0413	31,36	lapatinib	S0413	MESH:C490728	1076852(Tax:198215)	Chemical	Gene	trial|nmod|START_ENTITY END_ENTITY|dep|trial	Southwest Oncology Group study S0413 : a phase II trial of lapatinib -LRB- GW572016 -RRB- as first-line therapy in patients with advanced or metastatic gastric_cancer .
20936340	0	lapatinib	43,52	TGF-a	11,16	lapatinib	TGF-a	MESH:C490728	7124	Chemical	Gene	predicts|nmod|START_ENTITY predicts|nsubj|END_ENTITY	High serum TGF-a predicts poor response to lapatinib and capecitabine in HER2-positive_breast_cancer .
22511346	0	lapatinib	15,24	cytochrome_P450_3A5	30,49	lapatinib	cytochrome P450 3A5	MESH:C490728	1577	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of lapatinib with cytochrome_P450_3A5 .
17635524	0	lapatinib	120,129	epidermal_growth_factor_receptor	14,46	lapatinib	epidermal growth factor receptor	MESH:C490728	1956	Chemical	Gene	levels|nmod|START_ENTITY protein|dobj|levels protein|nsubj|Assessment Assessment|nmod|END_ENTITY	Assessment of epidermal_growth_factor_receptor -LRB- EGFR , ErbB1 -RRB- and HER2 -LRB- ErbB2 -RRB- protein expression levels and response to lapatinib -LRB- Tykerb , GW572016 -RRB- in an expanded panel of human normal and tumour cell lines .
18199554	0	lapatinib	107,116	epidermal_growth_factor_receptor	17,49	lapatinib	epidermal growth factor receptor	MESH:C490728	1956	Chemical	Gene	variants|nmod|START_ENTITY variants|nsubj|Impact Impact|nmod|END_ENTITY	Impact of common epidermal_growth_factor_receptor and HER2 variants on receptor activity and inhibition by lapatinib .
19620495	0	lapatinib	156,165	epidermal_growth_factor_receptor	95,127	lapatinib	epidermal growth factor receptor	MESH:C490728	1956	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Estrogen_receptor , progesterone_receptor , human epidermal_growth_factor_receptor_2 -LRB- HER2 -RRB- , and epidermal_growth_factor_receptor expression and benefit from lapatinib in a randomized trial of paclitaxel with lapatinib or placebo as first-line treatment in HER2-negative or unknown metastatic_breast_cancer .
19620495	0	lapatinib	207,216	epidermal_growth_factor_receptor	95,127	lapatinib	epidermal growth factor receptor	MESH:C490728	1956	Chemical	Gene	paclitaxel|nmod|START_ENTITY trial|nmod|paclitaxel lapatinib|nmod|trial expression|nmod|lapatinib expression|compound|END_ENTITY	Estrogen_receptor , progesterone_receptor , human epidermal_growth_factor_receptor_2 -LRB- HER2 -RRB- , and epidermal_growth_factor_receptor expression and benefit from lapatinib in a randomized trial of paclitaxel with lapatinib or placebo as first-line treatment in HER2-negative or unknown metastatic_breast_cancer .
19881954	0	lapatinib	97,106	epidermal_growth_factor_receptor	28,60	lapatinib	epidermal growth factor receptor	MESH:C490728	1956	Chemical	Gene	sensitivity|amod|START_ENTITY prediction|nmod|sensitivity profiling|nmod|prediction END_ENTITY|xcomp|profiling	Comparison of global versus epidermal_growth_factor_receptor pathway profiling for prediction of lapatinib sensitivity in bladder_cancer .
21080629	0	lapatinib	59,68	epidermal_growth_factor_receptor	102,134	lapatinib	epidermal growth factor receptor	MESH:C490728	1956	Chemical	Gene	hybrides|amod|START_ENTITY hybrides|nmod|inhibitors inhibitors|nmod|END_ENTITY	Novel chimeric histone deacetylase inhibitors : a series of lapatinib hybrides as potent inhibitors of epidermal_growth_factor_receptor -LRB- EGFR -RRB- , human epidermal_growth_factor_receptor 2 -LRB- HER2 -RRB- , and histone deacetylase activity .
17761983	0	lapatinib	18,27	erbB2	95,100	lapatinib	erbB2	MESH:C490728	2064	Chemical	Gene	study|nmod|START_ENTITY END_ENTITY|nsubj|study	Phase II study of lapatinib in recurrent or metastatic epidermal_growth_factor_receptor and/or erbB2 expressing adenoid_cystic_carcinoma and non adenoid_cystic_carcinoma malignant tumors of the salivary glands .
19574203	0	lapatinib	168,177	mTOR	0,4	lapatinib	mTOR	MESH:C490728	21977(Tax:10090)	Chemical	Gene	resistance|nmod|START_ENTITY management|nmod|resistance insights|nmod|management inhibitors|dep|insights inhibitors|compound|END_ENTITY	mTOR inhibitors and the anti-diabetic biguanide_metformin : new insights into the molecular management of breast_cancer resistance to the HER2 tyrosine kinase inhibitor lapatinib -LRB- Tykerb -RRB- .
22043997	0	lapatinib	42,51	mTOR	28,32	lapatinib	mTOR	MESH:C490728	21977(Tax:10090)	Chemical	Gene	sensitivity|amod|START_ENTITY improves|dobj|sensitivity improves|nsubj|inhibition inhibition|nmod|END_ENTITY	Pharmacologic inhibition of mTOR improves lapatinib sensitivity in HER2-overexpressing breast_cancer cells with primary trastuzumab resistance .
24057042	0	lapatinib	44,53	mTOR	105,109	lapatinib	mTOR	MESH:C490728	21977(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Phase I study evaluating the combination of lapatinib -LRB- a Her2/Neu and EGFR inhibitor -RRB- and everolimus -LRB- an mTOR inhibitor -RRB- in patients with advanced cancers : South West Oncology Group -LRB- SWOG -RRB- Study S0528 .
25692408	0	lapatinib	42,51	mTOR	118,122	lapatinib	mTOR	MESH:C490728	21977(Tax:10090)	Chemical	Gene	resistance|amod|START_ENTITY resistance|acl:relcl|reversed reversed|nmod|inhibition inhibition|compound|END_ENTITY	PI3K-independent mTOR activation promotes lapatinib resistance and IAP expression that can be effectively reversed by mTOR and Hsp90 inhibition .
25692408	0	lapatinib	42,51	mTOR	17,21	lapatinib	mTOR	MESH:C490728	21977(Tax:10090)	Chemical	Gene	resistance|amod|START_ENTITY promotes|dobj|resistance promotes|nsubj|activation activation|compound|END_ENTITY	PI3K-independent mTOR activation promotes lapatinib resistance and IAP expression that can be effectively reversed by mTOR and Hsp90 inhibition .
15764719	9	laquinimod	1493,1503	CYP3A4	1536,1542	laquinimod	CYP3A4	MESH:C476223	1576	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	In conclusion , the present study demonstrates that laquinimod is a low affinity substrate for CYP3A4 in human liver microsomes .
16368922	0	lasofoxifene	24,36	CYP2D6	40,46	lasofoxifene	CYP2D6	MESH:C111332	1565	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|metabolism metabolism|amod|END_ENTITY	Effects of steady-state lasofoxifene on CYP2D6 - and CYP2E1-mediated metabolism .
24782228	0	lavandulyl_flavonoids	55,76	Protein_tyrosine_phosphatase_1B	0,31	lavandulyl flavonoids	Protein tyrosine phosphatase 1B	null	5770	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Protein_tyrosine_phosphatase_1B inhibitory activity of lavandulyl_flavonoids from roots of Sophora flavescens .
11078389	8	lavendustin_A	1233,1246	EGF	1184,1187	lavendustin A	HGF	MESH:C062898	100316908(Tax:9986)	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	The inhibition of EGF and HGF receptor tyrosine kinase activity by lavendustin_A was confirmed by Western blotting .
10626094	0	lazabemide	16,26	MAO-B	46,51	lazabemide	MAO-B	MESH:C059303	4129	Chemical	Gene	study|nmod|START_ENTITY study|appos|inhibitor inhibitor|amod|END_ENTITY	Safety study of lazabemide -LRB- Ro19-6327 -RRB- , a new MAO-B inhibitor , on cardiac_arrhythmias and blood pressure of patients with Parkinson 's _ disease .
9056051	0	lazabemide	90,100	MAO-B	74,79	lazabemide	MAO-B	MESH:C059303	4129	Chemical	Gene	START_ENTITY|nsubj|Pharmacokinetics Pharmacokinetics|nmod|doses doses|nmod|inhibitor inhibitor|amod|END_ENTITY	Pharmacokinetics and pharmacodynamics of single and multiple doses of the MAO-B inhibitor lazabemide in healthy subjects .
10927030	0	lazabemide	58,68	monoamine_oxidase_B	28,47	lazabemide	monoamine oxidase B	MESH:C059303	4129	Chemical	Gene	START_ENTITY|nsubj|activity activity|nmod|inhibitor inhibitor|amod|END_ENTITY	Antioxidant activity of the monoamine_oxidase_B inhibitor lazabemide .
17570647	0	lazabemide	36,46	monoamine_oxidase_B	51,70	lazabemide	monoamine oxidase B	MESH:C059303	4129	Chemical	Gene	Ro_19-6327|appos|START_ENTITY Specific|nmod|Ro_19-6327 Specific|nmod|END_ENTITY	Specific binding of -LSB- 3H -RSB- Ro_19-6327 -LRB- lazabemide -RRB- to monoamine_oxidase_B is increased in frontal cortex of suicide victims after controlling for age at death .
7917773	0	lazabemide	20,30	monoamine_oxidase_B	72,91	lazabemide	monoamine oxidase B	MESH:C059303	4129	Chemical	Gene	Pharmacodynamics|nmod|START_ENTITY Pharmacodynamics|appos|inhibitor inhibitor|nmod|END_ENTITY	Pharmacodynamics of lazabemide , a reversible and selective inhibitor of monoamine_oxidase_B .
18172893	0	leachates	32,41	ROS	89,92	leachates	ROS	null	44175	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|role role|nmod|END_ENTITY	Adverse effect of tannery waste leachates in transgenic Drosophila_melanogaster : role of ROS in modulation of Hsp70 , oxidative stress and apoptosis .
18590793	0	lead_acetate	95,107	CL3	111,114	lead acetate	CL3	MESH:C008261	23284	Chemical	Gene	START_ENTITY|nmod|cells cells|nummod|END_ENTITY	Activation of protein kinase Calpha signaling prevents cytotoxicity and mutagenicity following lead_acetate in CL3 human lung_cancer cells .
22356714	0	lead_acetate	22,34	HK-2	116,120	lead acetate	HK-2	MESH:C008261	3099	Chemical	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- The toxic effects of lead_acetate on the apoptosis and the ultrastructure in human renal tubular epithelial cells -LRB- HK-2 -RRB- -RSB- .
2137898	0	lead_acetate	15,27	atrial_natriuretic_factor	33,58	lead acetate	atrial natriuretic factor	MESH:C008261	24602(Tax:10116)	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of lead_acetate with atrial_natriuretic_factor in rats .
17181941	0	lead_acetate	12,24	brain-derived_neurotropic_factor	42,74	lead acetate	brain-derived neurotropic factor	MESH:C008261	24225(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of lead_acetate on expression of brain-derived_neurotropic_factor and P75NTR in rat brain -RSB- .
14761347	0	lead_acetate	11,23	nerve_growth_factor	31,50	lead acetate	nerve growth factor	MESH:C008261	310738(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	-LSB- Effect of lead_acetate on the nerve_growth_factor protein expression and the regulation of thyroid hormone -RSB- .
23100028	0	leflunomide	35,46	Aryl_hydrocarbon_receptor	0,25	leflunomide	Aryl hydrocarbon receptor	MESH:C045463	11622(Tax:10090)	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Aryl_hydrocarbon_receptor agonist , leflunomide , protects the ischemic-reperfused kidney : role of Tregs and stem cells .
15210065	0	leflunomide	21,32	CCl4	64,68	leflunomide	CCl4	MESH:C045463	116637(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY induced|nsubj|effect induced|nmod|END_ENTITY	Inhibitory effect of leflunomide on hepatic_fibrosis induced by CCl4 in rats .
19443940	0	leflunomide	117,128	IL-6	10,14	leflunomide	IL-6	MESH:C045463	3569	Chemical	Gene	affect|nmod|START_ENTITY affect|nsubj|END_ENTITY	IL-1beta , IL-6 , and TNF gene polymorphisms do not affect the treatment outcome of rheumatoid_arthritis patients with leflunomide .
9469413	0	leflunomide	84,95	JAK3	14,18	leflunomide	JAK3	MESH:C045463	3718	Chemical	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Inhibition of JAK3 and STAT6 tyrosine phosphorylation by the immunosuppressive drug leflunomide leads to a block in IgG1 production .
22245957	0	leflunomide	131,142	MEK1/2	39,45	leflunomide	MEK1/2	MESH:C045463	170851;58960	Chemical	Gene	comparison|nmod|START_ENTITY effect|dep|comparison effect|nmod|inhibitor inhibitor|compound|END_ENTITY	Suppressive effect of an orally active MEK1/2 inhibitor in two different animal models for rheumatoid_arthritis : a comparison with leflunomide .
18036589	0	leflunomide	23,34	TIMP-1	53,59	leflunomide	TIMP-1	MESH:C045463	7076	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Suppressive effects of leflunomide on leptin-induced TIMP-1 production involves on hepatic stellate cell proliferation and apoptosis .
20650041	0	leflunomide	41,52	immunoglobulin_A	99,115	leflunomide	immunoglobulin A	MESH:C045463	973	Chemical	Gene	START_ENTITY|nmod|treatment treatment|nmod|END_ENTITY	Comparison of the therapeutic effects of leflunomide and mycophenolate_mofetil in the treatment of immunoglobulin_A nephropathy manifesting with nephrotic_syndrome .
18957484	0	leflunomide	61,72	tumour_necrosis_factor	14,36	leflunomide	tumour necrosis factor	MESH:C045463	7124	Chemical	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	Inhibition of tumour_necrosis_factor and IL-17 production by leflunomide involves the JAK/STAT pathway .
5073749	0	leghaemoglobins	45,60	lupin	24,29	leghaemoglobins	lupin	null	51251	Chemical	Gene	START_ENTITY|nsubj|properties properties|nmod|END_ENTITY	Molecular properties of lupin and serradella leghaemoglobins .
22150117	0	lenalidomide	56,68	HLA-DRB1	114,122	lenalidomide	HLA-DRB1	MESH:C467567	3123	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	Severe dermatologic adverse reactions after exposure to lenalidomide in multiple myeloma patients with a positive HLA-DRB1 * 1501 and HLA-DQB1 * 0602 .
26051632	0	lenalidomide	77,89	ICOS-L	34,40	lenalidomide	ICOS-L	MESH:C467567	23308	Chemical	Gene	therapy|amod|START_ENTITY END_ENTITY|nmod|therapy	Downregulation of myeloma-induced ICOS-L and regulatory T cell generation by lenalidomide and dexamethasone therapy .
21825263	0	lenalidomide-CCI-779	99,119	P-glycoprotein	136,150	lenalidomide-CCI-779	P-glycoprotein	null	5243	Chemical	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	Phase I trial of lenalidomide and CCI-779 in patients with relapsed multiple myeloma : evidence for lenalidomide-CCI-779 interaction via P-glycoprotein .
12013506	0	lentinan	30,38	Th1	15,18	lentinan	Th1	MESH:D007912	57314(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	The skewing to Th1 induced by lentinan is directed through the distinctive cytokine production by macrophages with elevated intracellular glutathione content .
6982258	0	lentinan	14,22	interleukin-1	40,53	lentinan	interleukin-1	MESH:D007912	3552	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of lentinan on production of interleukin-1 by human monocytes .
16868253	0	lestaurtinib	15,27	FLT3	127,131	lestaurtinib	FLT3	MESH:C119379	2322	Chemical	Gene	effects|nmod|START_ENTITY varies|nsubj|effects varies|advcl|signaling signaling|nsubj|dependence dependence|nmod|END_ENTITY	The effects of lestaurtinib -LRB- CEP701 -RRB- and PKC412 on primary AML blasts : the induction of cytotoxicity varies with dependence on FLT3 signaling in both FLT3-mutated and wild-type cases .
18341639	0	lestaurtinib	105,117	FLT3	136,140	lestaurtinib	FLT3	MESH:C119379	2322	Chemical	Gene	START_ENTITY|nmod|those those|nmod|duplication duplication|compound|END_ENTITY	Acute_myeloid_leukaemia blast cells with a tyrosine kinase domain mutation of FLT3 are less sensitive to lestaurtinib than those with a FLT3 internal tandem duplication .
18341639	0	lestaurtinib	105,117	FLT3	78,82	lestaurtinib	FLT3	MESH:C119379	2322	Chemical	Gene	sensitive|xcomp|START_ENTITY sensitive|nsubj|cells cells|nmod|mutation mutation|nmod|END_ENTITY	Acute_myeloid_leukaemia blast cells with a tyrosine kinase domain mutation of FLT3 are less sensitive to lestaurtinib than those with a FLT3 internal tandem duplication .
21270442	0	lestaurtinib	68,80	FLT3	99,103	lestaurtinib	FLT3	MESH:C119379	2322	Chemical	Gene	followed|nmod|START_ENTITY followed|nmod|AML AML|compound|END_ENTITY	Results from a randomized trial of salvage chemotherapy followed by lestaurtinib for patients with FLT3 mutant AML in first relapse .
21992075	0	letrozole	124,133	HER2	88,92	letrozole	HER2	MESH:C067431	2064	Chemical	Gene	+|nmod|START_ENTITY +|nsubj|analysis analysis|nmod|treatment treatment|nmod|END_ENTITY	Quality-adjusted survival analysis of first-line treatment of hormone-receptor-positive HER2 + metastatic breast_cancer with letrozole alone or in combination with lapatinib .
18249394	0	letrozole	11,20	HOXA10	65,71	letrozole	HOXA10	MESH:C067431	103692129	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of letrozole and clomiphene_citrate on the expression of HOXA10 and integrin_alpha_v_beta_3 in uterine epithelium of rats .
17092402	0	letrozole	61,70	Mammalian_target_of_rapamycin	0,29	letrozole	Mammalian target of rapamycin	MESH:C067431	2475	Chemical	Gene	inhibitors|nmod|START_ENTITY inhibitors|nsubj|END_ENTITY	Mammalian_target_of_rapamycin inhibitors in combination with letrozole in breast_cancer .
26690356	0	letrozole	29,38	VEGF	114,118	letrozole	VEGF	MESH:C067431	83785(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY Comparison|nmod|effects Comparison|nmod|levels levels|compound|END_ENTITY	Comparison of the effects of letrozole and cabergoline on vascular_permeability , ovarian diameter , ovarian tissue VEGF levels , and blood PEDF levels , in a rat model of ovarian_hyperstimulation_syndrome .
18487213	0	letrozole	35,44	aromatase	15,24	letrozole	aromatase	MESH:C067431	25147(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Effects of the aromatase inhibitor letrozole on in utero development in rats .
16648119	0	letrozole	96,105	endostatin	6,16	letrozole	endostatin	MESH:C067431	80781	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|END_ENTITY	Serum endostatin and bFGF as predictive factors in advanced_breast_cancer patients treated with letrozole .
26861603	0	letrozole	42,51	hormone_receptor	86,102	letrozole	hormone receptor	MESH:C067431	3164	Chemical	Gene	START_ENTITY|nmod|therapy therapy|nmod|END_ENTITY	Observation versus late reintroduction of letrozole as adjuvant endocrine therapy for hormone_receptor positive breast_cancer -LRB- ANZ0501 LATER -RRB- : An open-label randomised controlled trial .
11986236	0	leucine	9,16	AF10	4,8	leucine	AF10	CHEBI:25017	17354(Tax:10090)	Chemical	Gene	zipper|compound|START_ENTITY zipper|compound|END_ENTITY	The AF10 leucine zipper is required for leukemic transformation of myeloid progenitors by MLL-AF10 .
25515956	0	leucine	67,74	APE2	87,91	leucine	APE2	CHEBI:25017	77622(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	New synthetic sulfone derivatives inhibit growth , adhesion and the leucine arylamidase APE2 gene expression of Candida_albicans in vitro .
20592017	4	leucine	827,834	ATF3	822,826	leucine	MDM2	CHEBI:25017	4193	Chemical	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	MDM2 via its C-terminal RING finger can bind to the Basic region of ATF3 and mediate the addition of ubiquitin moieties to the ATF3 leucine zipper domain .
17719007	0	leucine	35,42	AtbZIP34	60,68	leucine	AtbZIP34	CHEBI:25017	818839(Tax:3702)	Chemical	Gene	region|amod|START_ENTITY region|nmod|END_ENTITY	A conserved proline residue in the leucine zipper region of AtbZIP34 and AtbZIP61 in Arabidopsis_thaliana interferes with the formation of homodimer .
1847997	0	leucine	126,133	C/EBP	120,125	leucine	C/EBP	CHEBI:25017	1050	Chemical	Gene	zipper|compound|START_ENTITY zipper|compound|END_ENTITY	The BZLF1 protein of EBV has a coiled coil dimerisation domain without a heptad leucine repeat but with homology to the C/EBP leucine zipper .
2532887	0	leucine	38,45	C/EBP	64,69	leucine	C/EBP	CHEBI:25017	1050	Chemical	Gene	regions|amod|START_ENTITY regions|nmod|GCN4 GCN4|compound|END_ENTITY	Conformational energy analysis of the leucine repeat regions of C/EBP , GCN4 , and the proteins of the myc , jun , and fos oncogenes .
7891686	0	leucine	41,48	C/EBP	100,105	leucine	C/EBP	CHEBI:25017	37889(Tax:7227)	Chemical	Gene	protein|compound|START_ENTITY specificity|nmod|protein overlaps|nsubj|specificity overlaps|dobj|those those|nmod|families families|compound|END_ENTITY	DNA-binding specificity of the PAR basic leucine zipper protein VBP partially overlaps those of the C/EBP and CREB/ATF families and is influenced by domains that flank the core basic region .
8997490	0	leucine	41,48	C/EBP	106,111	leucine	C/EBP	CHEBI:25017	25301(Tax:10116)	Chemical	Gene	START_ENTITY|parataxis|confers confers|nsubj|substitution substitution|nmod|domain domain|compound|END_ENTITY	DNA-binding specificity of PAR and C/EBP leucine zipper proteins : a single amino_acid substitution in the C/EBP DNA-binding domain confers PAR-like specificity to C/EBP .
8997490	0	leucine	41,48	C/EBP	163,168	leucine	C/EBP	CHEBI:25017	25301(Tax:10116)	Chemical	Gene	START_ENTITY|parataxis|confers confers|nmod|END_ENTITY	DNA-binding specificity of PAR and C/EBP leucine zipper proteins : a single amino_acid substitution in the C/EBP DNA-binding domain confers PAR-like specificity to C/EBP .
8058339	0	leucine	33,40	CHOP	58,62	leucine	CHOP	CHEBI:25017	1649	Chemical	Gene	region|amod|START_ENTITY region|nmod|END_ENTITY	Rare variant -LRB- Glu to Lys -RRB- in the leucine zipper region of CHOP -LRB- GADD153 -RRB- .
20979941	0	leucine	44,51	CNDP1	38,43	leucine	CNDP1	CHEBI:25017	84735	Chemical	Gene	START_ENTITY|nsubj|Relationship Relationship|nmod|END_ENTITY	Relationship between carnosinase gene CNDP1 leucine repeat polymorphism and the clinical outcome of Chinese PD patients .
2139203	0	leucine	18,25	CRE-BP1	83,90	leucine	CRE-BP1	CHEBI:25017	1386	Chemical	Gene	proteins|amod|START_ENTITY cloning|nmod|proteins cloning|parataxis|binds binds|nmod|CRE CRE|nmod|END_ENTITY	Direct cloning of leucine zipper proteins : Jun binds cooperatively to the CRE with CRE-BP1 .
17616745	0	leucine	9,16	CREB	4,8	leucine	CREB	CHEBI:25017	12912(Tax:10090)	Chemical	Gene	zipper|compound|START_ENTITY zipper|compound|END_ENTITY	The CREB leucine zipper regulates CREB phosphorylation , cardiomyopathy , and lethality in a transgenic model of heart_failure .
17696880	0	leucine	112,119	CREB	101,105	leucine	CREB	CHEBI:25017	81646(Tax:10116)	Chemical	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	Enhancement by lithium of cAMP-induced CRE/CREB-directed gene transcription conferred by TORC on the CREB basic leucine zipper domain .
16340007	0	leucine	4,11	DNA-PKcs	27,35	leucine	DNA-PKcs	CHEBI:25017	5591	Chemical	Gene	region|amod|START_ENTITY region|nmod|END_ENTITY	The leucine rich region of DNA-PKcs contributes to its innate DNA affinity .
10397789	0	leucine	80,87	Fos	63,66	leucine	Fos	CHEBI:25017	2353	Chemical	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	Addition of positively charged tripeptide to N-terminus of the Fos basic region leucine zipper domain : implications on DNA bending , affinity , and specificity .
1473154	0	leucine	22,29	GCN4	4,8	leucine	GCN4	CHEBI:25017	856709(Tax:4932)	Chemical	Gene	zipper|compound|START_ENTITY zipper|compound|END_ENTITY	The GCN4 basic region leucine zipper binds DNA as a dimer of uninterrupted alpha helices : crystal structure of the protein-DNA complex .
1948029	0	leucine	28,35	GCN4	23,27	leucine	GCN4	CHEBI:25017	856709(Tax:4932)	Chemical	Gene	zipper|compound|START_ENTITY zipper|compound|END_ENTITY	X-ray structure of the GCN4 leucine zipper , a two-stranded , parallel coiled coil .
8102921	0	leucine	67,74	GCN4	62,66	leucine	GCN4	CHEBI:25017	856709(Tax:4932)	Chemical	Gene	zipper|compound|START_ENTITY zipper|compound|END_ENTITY	Probing the roles of residues at the e and g positions of the GCN4 leucine zipper by combinatorial mutagenesis .
8441750	0	leucine	62,69	GCN4	57,61	leucine	GCN4	CHEBI:25017	856709(Tax:4932)	Chemical	Gene	domain|amod|START_ENTITY domain|compound|END_ENTITY	Successful prediction of the coiled coil geometry of the GCN4 leucine zipper domain by simulated annealing : comparison to the X-ray structure .
9737882	0	leucine	96,103	GCN4	142,146	leucine	GCN4	CHEBI:25017	856709(Tax:4932)	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Thermodynamics and kinetics of the reaction of a single-chain antibody fragment -LRB- scFv -RRB- with the leucine zipper domain of transcription factor GCN4 .
15336700	0	leucine	74,81	GILZ	90,94	leucine	GILZ	CHEBI:25017	1831	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cell type-specific bidirectional regulation of the glucocorticoid-induced leucine zipper -LRB- GILZ -RRB- gene by estrogen .
22396737	0	leucine	23,30	GILZ	39,43	leucine	GILZ	CHEBI:25017	14605(Tax:10090)	Chemical	Gene	zipper|compound|START_ENTITY zipper|appos|END_ENTITY	Glucocorticoid-induced leucine zipper -LRB- GILZ -RRB- antagonizes TNF-a inhibition of mesenchymal stem cell osteogenic differentiation .
22571926	0	leucine	27,34	GILZ	43,47	leucine	GILZ	CHEBI:25017	14605(Tax:10090)	Chemical	Gene	zipper|compound|START_ENTITY zipper|appos|END_ENTITY	The Glucocorticoid-induced leucine zipper -LRB- GILZ -RRB- Is essential for spermatogonial survival and spermatogenesis .
23573276	0	leucine	98,105	GILZ	114,118	leucine	GILZ	CHEBI:25017	1831	Chemical	Gene	zipper|compound|START_ENTITY zipper|appos|END_ENTITY	Dexamethasone inhibits repair of human airway epithelial cells mediated by glucocorticoid-induced leucine zipper -LRB- GILZ -RRB- .
7760820	0	leucine	95,102	HLF	133,136	leucine	HLF	CHEBI:25017	217082(Tax:10090)	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	E2A-HLF-mediated cell transformation requires both the trans-activation domains of E2A and the leucine zipper dimerization domain of HLF .
8288566	0	leucine	32,39	IFP_35	0,6	leucine	IFP 35	CHEBI:25017	3430	Chemical	Gene	protein|amod|START_ENTITY protein|nsubj|END_ENTITY	IFP_35 is an interferon-induced leucine zipper protein that undergoes interferon-regulated cellular redistribution .
10878360	0	leucine	56,63	IL-2	14,18	leucine	IL-2	CHEBI:25017	3558	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Repression of IL-2 promoter activity by the novel basic leucine zipper p21SNFT protein .
24715028	0	leucine	8,15	INS-1	99,104	leucine	INS-1	CHEBI:25017	24505(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Chronic leucine exposure results in reduced but reversible glucose-stimulated insulin secretion in INS-1 cells .
10705078	0	leucine	16,23	Insulin	0,7	leucine	Insulin	CHEBI:25017	3630	Chemical	Gene	oxidation|amod|START_ENTITY reduces|dobj|oxidation reduces|nsubj|END_ENTITY	Insulin reduces leucine oxidation and improves net leucine retention in parenterally fed humans .
12173727	0	leucine	18,25	Insulin	0,7	leucine	Insulin	CHEBI:25017	3630	Chemical	Gene	effect|nmod|START_ENTITY effect|compound|END_ENTITY	Insulin effect on leucine kinetics in type_2_diabetes_mellitus .
8779949	0	leucine	65,72	Insulin	0,7	leucine	Insulin	CHEBI:25017	3630	Chemical	Gene	turnover|compound|START_ENTITY regulate|nmod|turnover regulate|nsubj|END_ENTITY	Insulin and hyperaminoacidemia regulate by a different mechanism leucine turnover and oxidation in obesity .
15987681	0	leucine	58,65	JLP	0,3	leucine	JLP	CHEBI:25017	9043	Chemical	Gene	START_ENTITY|nsubj|associates associates|compound|END_ENTITY	JLP associates with kinesin_light_chain_1 through a novel leucine zipper-like domain .
2506451	0	leucine	33,40	Jun	29,32	leucine	Jun	CHEBI:25017	3725	Chemical	Gene	zipper|compound|START_ENTITY zipper|compound|END_ENTITY	A Fos protein containing the Jun leucine zipper forms a homodimer which binds to the AP1 binding site .
8112339	0	leucine	58,65	Jun	54,57	leucine	Jun	CHEBI:25017	3725	Chemical	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	Cloning , expression , and spectroscopic studies of the Jun leucine zipper domain .
1223816	0	leucine	25,32	LAP	46,49	leucine	LAP	CHEBI:25017	7939	Chemical	Gene	START_ENTITY|dobj|activity activity|appos|END_ENTITY	Non-homogeneity of serum leucine arylamidase -LRB- LAP -RRB- activity in hepatocellular_and_obstructive_jaundice .
3135759	0	leucine	52,59	LAP	76,79	leucine	LAP	CHEBI:25017	66988(Tax:10090)	Chemical	Gene	aminopeptidase|amod|START_ENTITY aminopeptidase|appos|END_ENTITY	Effect of praziquantel on Schistosoma_mansoni eggs : leucine aminopeptidase -LRB- LAP -RRB- activity and anti-LAP antibodies .
17847094	0	leucine	99,106	LeuT	90,94	leucine	LeuT	CHEBI:25017	3343	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Dopamine_transporter comparative molecular modeling and binding site prediction using the LeuT -LRB- Aa -RRB- leucine transporter as a template .
18708457	0	leucine	79,86	LeuT	99,103	leucine	LeuT	CHEBI:25017	3343	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Molecular mechanism of ion-ion and ion-substrate coupling in the Na + - dependent leucine transporter LeuT .
22908980	0	leucine	99,106	LeuT	120,124	leucine	LeuT	CHEBI:25017	3343	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	A virtual high-throughput screening approach to the discovery of novel inhibitors of the bacterial leucine transporter , LeuT .
22424946	0	leucine	43,50	Leucyl-tRNA_synthetase	0,22	leucine	Leucyl-tRNA synthetase	CHEBI:25017	51520	Chemical	Gene	sensor|compound|START_ENTITY sensor|nsubj|END_ENTITY	Leucyl-tRNA_synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway .
17463046	0	leucine	62,69	Mammalian_target_of_rapamycin	0,29	leucine	Mammalian target of rapamycin	CHEBI:25017	2475	Chemical	Gene	transport|amod|START_ENTITY regulates|dobj|transport regulates|nsubj|END_ENTITY	Mammalian_target_of_rapamycin in the human placenta regulates leucine transport and is down-regulated in restricted fetal growth .
9416837	0	leucine	8,15	Myb	4,7	leucine	Myb	CHEBI:25017	396244(Tax:9031)	Chemical	Gene	zipper|compound|START_ENTITY zipper|compound|END_ENTITY	The Myb leucine zipper is essential for leukemogenicity of the v-Myb protein .
8288222	0	leucine	55,62	Nrl	76,79	leucine	Nrl	CHEBI:25017	18185(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|gene gene|appos|END_ENTITY	Molecular characterization of the murine neural retina leucine zipper gene , Nrl .
17394774	0	leucine	42,49	P13	72,75	leucine	P13	CHEBI:25017	440926	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Function and oligomerization study of the leucine zipper-like domain in P13 from Leucania separata multiple_nuclear_polyhedrosis_virus .
10944455	0	leucine	15,22	RBP95	0,5	leucine	RBP95	CHEBI:25017	9810	Chemical	Gene	protein|amod|START_ENTITY END_ENTITY|appos|protein	RBP95 , a novel leucine zipper protein , binds to the retinoblastoma protein .
10862766	5	leucine	840,847	SPRK	865,869	leucine	SPRK	CHEBI:25017	26403(Tax:10090)	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	The leucine zipper domain of SPRK has been shown to be necessary and sufficient for SPRK oligomerization , but its role in regulating activation of SPRK and downstream signaling remains unclear .
10847161	0	leucine	21,28	aminopeptidase	29,43	leucine	aminopeptidase	CHEBI:25017	10404	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Downstream change in leucine aminopeptidase activity and leucine assimilation by epilithic microbiota along the River Swale , northern England .
10888337	0	leucine	11,18	aminopeptidase	19,33	leucine	aminopeptidase	CHEBI:25017	10404	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	Potent new leucine aminopeptidase inhibitor of novel structure synthesised by a modified Wadsworth-Emmons -LRB- Horner -RRB- Wittig procedure .
11064603	0	leucine	53,60	aminopeptidase	61,75	leucine	aminopeptidase	CHEBI:25017	10404	Chemical	Gene	START_ENTITY|dobj|activities activities|amod|END_ENTITY	-LSB- Comparison between leucyl_aminopeptidase and pseudo leucine aminopeptidase activities in sera -RSB- .
11101255	0	leucine	46,53	aminopeptidase	54,68	leucine	aminopeptidase	CHEBI:25017	10404	Chemical	Gene	microanalysis|nmod|START_ENTITY END_ENTITY|nsubj|microanalysis	Electrophoretically mediated microanalysis of leucine aminopeptidase using two-photon excited fluorescence detection on a microchip .
134272	0	leucine	27,34	aminopeptidase	35,49	leucine	aminopeptidase	CHEBI:25017	10404	Chemical	Gene	activity|nmod|START_ENTITY END_ENTITY|nsubj|activity	Histoenzymatic activity of leucine aminopeptidase in normal bone marrow cells .
14425685	0	leucine	49,56	aminopeptidase	57,71	leucine	aminopeptidase	CHEBI:25017	10404	Chemical	Gene	localization|nmod|START_ENTITY Improvement|nmod|localization END_ENTITY|nsubj|Improvement	Improvement in the histochemical localization of leucine aminopeptidase with a new substrate , L-leucyl-4-methoxy-2-naphthylamide .
158134	0	leucine	23,30	aminopeptidase	31,45	leucine	aminopeptidase	CHEBI:25017	10404	Chemical	Gene	study|nmod|START_ENTITY END_ENTITY|nsubj|study	Histochemical study of leucine aminopeptidase in leukemia .
16269763	0	leucine	14,21	aminopeptidase	86,100	leucine	aminopeptidase	CHEBI:25017	10404	Chemical	Gene	aminopeptidase|amod|START_ENTITY Alteration|nmod|aminopeptidase septatus|nsubj|Alteration septatus|xcomp|TH-2 TH-2|xcomp|phenylalanine phenylalanine|dobj|END_ENTITY	Alteration of leucine aminopeptidase from Streptomyces septatus TH-2 to phenylalanine aminopeptidase by site-directed mutagenesis .
1671193	0	leucine	101,108	aminopeptidase	109,123	leucine	aminopeptidase	CHEBI:25017	10404	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Differential modulation of human small intestinal brush-border membrane hemileaflet fluidity affects leucine aminopeptidase activity and transport of D-glucose and L-glutamate .
1712242	0	leucine	19,26	aminopeptidase	27,41	leucine	aminopeptidase	CHEBI:25017	10404	Chemical	Gene	Differences|nmod|START_ENTITY END_ENTITY|nsubj|Differences	Differences in the leucine aminopeptidase activity in extracts from human prostatic_carcinoma and benign_prostatic_hyperplasia .
19428710	0	leucine	31,38	aminopeptidase	39,53	leucine	aminopeptidase	CHEBI:25017	10404	Chemical	Gene	Refolding|nmod|START_ENTITY END_ENTITY|nsubj|Refolding	Refolding of hexameric porcine leucine aminopeptidase using a cationic detergent and dextrin-10 as artificial chaperones .
1965362	0	leucine	66,73	aminopeptidase	74,88	leucine	aminopeptidase	CHEBI:25017	10404	Chemical	Gene	studies|nmod|START_ENTITY Results|nmod|studies END_ENTITY|nsubj|Results	-LSB- Results of clinical and immunoenzymatic studies of neurospecific leucine aminopeptidase in patients with neurologic_disorders -RSB- .
21076540	0	leucine	55,62	aminopeptidase	63,77	leucine	aminopeptidase	CHEBI:25017	10404	Chemical	Gene	activity|nmod|START_ENTITY Characterization|nmod|activity END_ENTITY|nsubj|Characterization	Characterization of activity of a potential food-grade leucine aminopeptidase from kiwifruit .
21918843	0	leucine	73,80	aminopeptidase	81,95	leucine	aminopeptidase	CHEBI:25017	10404	Chemical	Gene	enzyme|amod|START_ENTITY enzyme|compound|END_ENTITY	Mechanism of peptide hydrolysis by co-catalytic metal centers containing leucine aminopeptidase enzyme : a DFT approach .
24202517	0	leucine	12,19	aminopeptidase	20,34	leucine	aminopeptidase	CHEBI:25017	10404	Chemical	Gene	Genetics|nmod|START_ENTITY END_ENTITY|nsubj|Genetics	Genetics of leucine aminopeptidase in apple .
2561118	0	leucine	6,13	aminopeptidase	14,28	leucine	aminopeptidase	CHEBI:25017	10404	Chemical	Gene	estimation|amod|START_ENTITY estimation|compound|END_ENTITY	Serum leucine aminopeptidase estimation : a sensitive prognostic indicator of invasiveness_in_breast_carcinoma .
2999016	0	leucine	61,68	aminopeptidase	69,83	leucine	aminopeptidase	CHEBI:25017	10404	Chemical	Gene	action|amod|START_ENTITY action|compound|END_ENTITY	Distinct behavior of beta-endorphin and corticotropin toward leucine aminopeptidase action .
3428362	0	leucine	21,28	aminopeptidase	29,43	leucine	aminopeptidase	CHEBI:25017	10404	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of microsomal leucine aminopeptidase from human placenta -LRB- microsomal P-LAP -RRB- on pressor response to infused angiotensin_II -LRB- A-II -RRB- in rat .
3663153	0	leucine	17,24	aminopeptidase	25,39	leucine	aminopeptidase	CHEBI:25017	397520(Tax:9823)	Chemical	Gene	behaviour|nmod|START_ENTITY END_ENTITY|nsubj|behaviour	The behaviour of leucine aminopeptidase towards thionopeptides .
3733731	0	leucine	52,59	aminopeptidase	60,74	leucine	aminopeptidase	CHEBI:25017	10404	Chemical	Gene	purification|nmod|START_ENTITY END_ENTITY|nsubj|purification	Immunoaffinity purification and characterization of leucine aminopeptidase from human liver .
3826759	0	leucine	44,51	aminopeptidase	52,66	leucine	aminopeptidase	CHEBI:25017	397520(Tax:9823)	Chemical	Gene	polymorphism|nmod|START_ENTITY END_ENTITY|nsubj|polymorphism	Electrophoretic polymorphism of erythrocyte leucine aminopeptidase in the wild_boar , Sus_scrofa .
4045387	0	leucine	45,52	aminopeptidase	53,67	leucine	aminopeptidase	CHEBI:25017	10404	Chemical	Gene	determination|nmod|START_ENTITY method|nmod|determination END_ENTITY|nsubj|method	A continuous method for the determination of leucine aminopeptidase in human serum with L-leucinamide as substrate .
5305395	0	leucine	27,34	aminopeptidase	35,49	leucine	aminopeptidase	CHEBI:25017	10404	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	-LSB- Histochemical evidence of leucine aminopeptidase activity in human skeletal muscle in myopathies -RSB- .
539001	0	leucine	19,26	aminopeptidase	27,41	leucine	aminopeptidase	CHEBI:25017	10404	Chemical	Gene	activity|nmod|START_ENTITY END_ENTITY|nsubj|activity	-LSB- Serum activity of leucine aminopeptidase in lymphotropic_infections and in malignant_lymphomas -RSB- .
5602584	0	leucine	21,28	aminopeptidase	29,43	leucine	aminopeptidase	CHEBI:25017	10404	Chemical	Gene	excretion|nmod|START_ENTITY END_ENTITY|nsubj|excretion	Urinary excretion of leucine aminopeptidase in pregnancy .
5894383	0	leucine	20,27	aminopeptidase	28,42	leucine	aminopeptidase	CHEBI:25017	10404	Chemical	Gene	START_ENTITY|dobj|level level|amod|END_ENTITY	-LSB- Study on the serum leucine aminopeptidase activity level in children -RSB- .
5946369	0	leucine	46,53	aminopeptidase	54,68	leucine	aminopeptidase	CHEBI:25017	10404	Chemical	Gene	START_ENTITY|dobj|phosphatase phosphatase|amod|END_ENTITY	The influence of steroids on serum bilirubin , leucine aminopeptidase and alkaline phosphatase in extrahepatic_obstructive_jaundice : the possible diagnostic importance .
606559	0	leucine	42,49	aminopeptidase	26,40	leucine	aminopeptidase	CHEBI:25017	10404	Chemical	Gene	START_ENTITY|nsubj|activities activities|nmod|END_ENTITY	The activities of alanine aminopeptidase , leucine aminopeptidase , proline_dipeptidase and prolyl dipeptidase in the mucosa of the small intestine .
606559	0	leucine	42,49	aminopeptidase	50,64	leucine	aminopeptidase	CHEBI:25017	10404	Chemical	Gene	START_ENTITY|dobj|dipeptidase dipeptidase|amod|END_ENTITY	The activities of alanine aminopeptidase , leucine aminopeptidase , proline_dipeptidase and prolyl dipeptidase in the mucosa of the small intestine .
639319	0	leucine	55,62	aminopeptidase	63,77	leucine	aminopeptidase	CHEBI:25017	10404	Chemical	Gene	determination|nmod|START_ENTITY END_ENTITY|nsubj|determination	A novel fluorometric ultramicro determination of serum leucine aminopeptidase using a coumarine derivative .
6830778	0	leucine	28,35	aminopeptidase	36,50	leucine	aminopeptidase	CHEBI:25017	10404	Chemical	Gene	localisation|nmod|START_ENTITY END_ENTITY|nsubj|localisation	Subcellular localisation of leucine aminopeptidase in human polymorphonuclear leukocytes .
7085655	0	leucine	14,21	aminopeptidase	22,36	leucine	aminopeptidase	CHEBI:25017	10404	Chemical	Gene	Inhibition|nmod|START_ENTITY END_ENTITY|nsubj|Inhibition	Inhibition of leucine aminopeptidase by amino_acid hydroxamates .
7180233	0	leucine	30,37	aminopeptidase	38,52	leucine	aminopeptidase	CHEBI:25017	10404	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	-LSB- Significance of the study of leucine aminopeptidase activity of the blood serum in patients with suppurative surgical infections -RSB- .
8670787	0	leucine	14,21	aminopeptidase	22,36	leucine	aminopeptidase	CHEBI:25017	10404	Chemical	Gene	Comparison|nmod|START_ENTITY END_ENTITY|nsubj|Comparison	Comparison of leucine aminopeptidase and aminopeptidase III activities in lens .
9767	0	leucine	57,64	aminopeptidase	65,79	leucine	aminopeptidase	CHEBI:25017	10404	Chemical	Gene	-RSB-|amod|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Influence of glutathione on the catalytic properties of leucine aminopeptidase -RSB- .
23453219	0	leucine	6,13	aminopeptidase_N	50,66	leucine	aminopeptidase N	CHEBI:25017	290	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Novel leucine ureido derivatives as inhibitors of aminopeptidase_N -LRB- APN -RRB- .
26651343	0	leucine	34,41	bZIP	50,54	leucine	bZIP	CHEBI:25017	843221(Tax:3702)	Chemical	Gene	zipper|compound|START_ENTITY zipper|appos|END_ENTITY	Genome-wide analysis of the basic leucine zipper -LRB- bZIP -RRB- transcription factor gene family in six legume genomes .
11773068	0	leucine	32,39	biliverdin_reductase	6,26	leucine	biliverdin reductase	CHEBI:25017	644	Chemical	Gene	protein|amod|START_ENTITY protein|nsubj|END_ENTITY	Human biliverdin_reductase is a leucine zipper-like DNA-binding protein and functions in transcriptional activation of heme_oxygenase-1 by oxidative stress .
2189105	0	leucine	4,11	cMyc	35,39	leucine	cMyc	CHEBI:25017	420332(Tax:9031)	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	The leucine zipper domain of avian cMyc is required for transformation and autoregulation .
23201843	0	leucine	113,120	elongation_factor_2	23,42	leucine	elongation factor 2	CHEBI:25017	29565(Tax:10116)	Chemical	Gene	responses|acl|START_ENTITY responses|nmod|END_ENTITY	Post-meal responses of elongation_factor_2 -LRB- eEF2 -RRB- and adenosine_monophosphate-activated protein kinase -LRB- AMPK -RRB- to leucine and carbohydrate supplements for regulating protein synthesis duration and energy homeostasis in rat skeletal muscle .
11303954	0	leucine	54,61	enkephalin	62,72	leucine	enkephalin	CHEBI:25017	29237(Tax:10116)	Chemical	Gene	analogue|amod|START_ENTITY analogue|compound|END_ENTITY	Development of novel lipophilic derivatives of DADLE -LRB- leucine enkephalin analogue -RRB- : intestinal permeability characateristics of DADLE derivatives in rats .
1685613	0	leucine	32,39	enkephalin	40,50	leucine	enkephalin	CHEBI:25017	29237(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|levels levels|compound|END_ENTITY	l-tetrahydropalmatine increases leucine enkephalin levels in corpus striatum of rats .
2143133	0	leucine	14,21	enkephalin	22,32	leucine	enkephalin	CHEBI:25017	29237(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|compound|END_ENTITY	Inhibition of leucine enkephalin metabolism in rat blood , plasma and tissues in vitro by an aminoboronic_acid derivative .
2423919	0	leucine	30,37	enkephalin	62,72	leucine	enkephalin	CHEBI:25017	29237(Tax:10116)	Chemical	Gene	enkephalin|amod|START_ENTITY enkephalin|dep|END_ENTITY	The glutamate_decarboxylase - , leucine enkephalin - , methionine enkephalin - and substance P-immunoreactive neurons in the neostriatum of the rat and cat : evidence for partial population overlap .
4011283	0	leucine	58,65	enkephalin	80,90	leucine	enkephalin	CHEBI:25017	29237(Tax:10116)	Chemical	Gene	self-administration|nmod|START_ENTITY study|nmod|self-administration END_ENTITY|nsubj|study	A study of intracerebroventricular self-administration of leucine or methionine enkephalin by rats in response to intermittent electric shocks .
7232228	0	leucine	21,28	enkephalin	44,54	leucine	enkephalin	CHEBI:25017	29237(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nsubj|effects	Pupillary effects of leucine and methionine enkephalin in rats after intraperitoneal administration .
8220661	0	leucine	34,41	enkephalin	42,52	leucine	enkephalin	CHEBI:25017	29237(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|level level|compound|END_ENTITY	Hypothalamic , striatal and plasma leucine enkephalin level in two rat models of portal_hypertension .
24993177	0	leucine	40,47	gilz	113,117	leucine	gilz	CHEBI:25017	14605(Tax:10090)	Chemical	Gene	protein|amod|START_ENTITY restores|nsubj|protein restores|dobj|control control|nmod|proliferation proliferation|nmod|spermatogonia spermatogonia|compound|END_ENTITY	Recombinant long-glucocorticoid-induced leucine zipper -LRB- L-GILZ -RRB- protein restores the control of proliferation in gilz KO spermatogonia .
2423919	0	leucine	30,37	glutamate_decarboxylase	4,27	leucine	glutamate decarboxylase	CHEBI:25017	24957(Tax:10116)	Chemical	Gene	enkephalin|amod|START_ENTITY END_ENTITY|dep|enkephalin	The glutamate_decarboxylase - , leucine enkephalin - , methionine enkephalin - and substance P-immunoreactive neurons in the neostriatum of the rat and cat : evidence for partial population overlap .
8662824	0	leucine	46,53	homodimer	81,90	leucine	homodimer	CHEBI:25017	6647	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	High resolution NMR solution structure of the leucine zipper domain of the c-Jun homodimer .
11502802	0	leucine	27,34	insulin	6,13	leucine	insulin	CHEBI:25017	3630	Chemical	Gene	Acute|xcomp|START_ENTITY Acute|dobj|responses responses|compound|END_ENTITY	Acute insulin responses to leucine in children with the hyperinsulinism/hyperammonemia syndrome .
11697442	0	leucine	38,45	insulin	11,18	leucine	insulin	CHEBI:25017	3630	Chemical	Gene	metabolism|amod|START_ENTITY Effects|nmod|metabolism Effects|nmod|END_ENTITY	Effects of insulin and amino_acids on leucine metabolism in young and middle-aged humans .
1539646	0	leucine	46,53	insulin	11,18	leucine	insulin	CHEBI:25017	3630	Chemical	Gene	infusion|nmod|START_ENTITY infusion|compound|END_ENTITY	Effects of insulin and amino_acid infusion on leucine and phenylalanine kinetics in type 1 diabetes .
1874488	0	leucine	57,64	insulin	10,17	leucine	insulin	CHEBI:25017	3630	Chemical	Gene	metabolism|amod|START_ENTITY amino_acid|nmod|metabolism amino_acid|nsubj|Effect Effect|nmod|END_ENTITY	Effect of insulin and plasma amino_acid concentration on leucine metabolism in cirrhosis .
1984571	0	leucine	46,53	insulin	24,31	leucine	insulin	CHEBI:25017	3630	Chemical	Gene	resistance|nmod|START_ENTITY resistance|compound|END_ENTITY	Differential effects of insulin resistance on leucine and glucose kinetics in obesity .
21059029	0	leucine	11,18	insulin	81,88	leucine	insulin	CHEBI:25017	100060077(Tax:9796)	Chemical	Gene	addition|compound|START_ENTITY addition|nmod|solution solution|nmod|END_ENTITY	Effects of leucine or whey protein addition to an oral glucose solution on serum insulin , plasma glucose and plasma amino_acid responses in horses at rest and following exercise .
23984046	0	leucine	13,20	insulin	87,94	leucine	insulin	CHEBI:25017	3630	Chemical	Gene	phenylalanine|amod|START_ENTITY Ingestion|nmod|phenylalanine produces|nsubj|Ingestion produces|nmod|END_ENTITY	Ingestion of leucine + phenylalanine with glucose produces an additive effect on serum insulin but less than additive effect on plasma glucose .
2571541	0	leucine	72,79	insulin	16,23	leucine	insulin	CHEBI:25017	3630	Chemical	Gene	metabolism|amod|START_ENTITY Contribution|nmod|metabolism Contribution|nmod|resistance resistance|compound|END_ENTITY	Contribution of insulin resistance to catabolic effect of prednisone on leucine metabolism in humans .
3316280	0	leucine	58,65	insulin	10,17	leucine	insulin	CHEBI:25017	3630	Chemical	Gene	metabolism|amod|START_ENTITY amino_acid|nmod|metabolism amino_acid|nsubj|Effect Effect|nmod|END_ENTITY	Effect of insulin and plasma amino_acid concentrations on leucine metabolism in man .
3318923	0	leucine	46,53	insulin	10,17	leucine	insulin	CHEBI:25017	105613195	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of insulin on hind-limb and whole-body leucine and protein metabolism in fed and fasted lambs .
6127347	0	leucine	37,44	insulin	8,15	leucine	insulin	CHEBI:25017	483665(Tax:9615)	Chemical	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Role of insulin in the regulation of leucine kinetics in the conscious dog .
6997015	0	leucine	14,21	insulin	48,55	leucine	insulin	CHEBI:25017	100009181(Tax:9986)	Chemical	Gene	Depression|nmod|START_ENTITY induced|nsubj|Depression induced|dobj|secretions secretions|compound|END_ENTITY	Depression of leucine and isoproterenol induced insulin secretions in the spontaneously diabetic New Zealand white rabbit .
7901997	0	leucine	60,67	insulin	93,100	leucine	insulin	CHEBI:25017	3630	Chemical	Gene	independent|amod|START_ENTITY independent|nmod|END_ENTITY	Increased fetal glucose concentration decreases ovine fetal leucine oxidation independent of insulin .
8163664	0	leucine	34,41	insulin	11,18	leucine	insulin	CHEBI:25017	3630	Chemical	Gene	kinetics|compound|START_ENTITY Effects|nmod|kinetics Effects|nmod|END_ENTITY	Effects of insulin on ovine fetal leucine kinetics and protein metabolism .
888951	0	leucine	39,46	insulin	18,25	leucine	insulin	CHEBI:25017	3630	Chemical	Gene	utilization|amod|START_ENTITY promoting|dobj|utilization Site|acl|promoting Site|nmod|END_ENTITY	Site of action of insulin in promoting leucine utilization in adipose tissue .
15987681	0	leucine	58,65	kinesin_light_chain_1	20,41	leucine	kinesin light chain 1	CHEBI:25017	3831	Chemical	Gene	START_ENTITY|nsubj|associates associates|nmod|END_ENTITY	JLP associates with kinesin_light_chain_1 through a novel leucine zipper-like domain .
9658067	0	leucine	64,71	luman	88,93	leucine	luman	CHEBI:25017	10488	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	The herpesvirus transactivator VP16 mimics a human basic domain leucine zipper protein , luman , in its interaction with HCF .
24695761	0	leucine	43,50	lysosome-associated_membrane_protein-1	61,99	leucine	lysosome-associated membrane protein-1	CHEBI:25017	3916	Chemical	Gene	mutant|compound|START_ENTITY mutant|nmod|END_ENTITY	Constitutive expression of a COOH-terminal leucine mutant of lysosome-associated_membrane_protein-1 causes its exclusive localization in low density intracellular vesicles .
11238775	0	leucine	8,15	mTOR	37,41	leucine	mTOR	CHEBI:25017	21977(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Role of leucine in the regulation of mTOR by amino_acids : revelations from structure-activity studies .
12812918	0	leucine	18,25	mTOR	80,84	leucine	mTOR	CHEBI:25017	21977(Tax:10090)	Chemical	Gene	metabolism|amod|START_ENTITY role|nmod|metabolism role|acl|involving involving|dobj|END_ENTITY	Potential role of leucine metabolism in the leucine-signaling pathway involving mTOR .
17978888	0	leucine	24,31	mTOR	53,57	leucine	mTOR	CHEBI:25017	21977(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|pathway pathway|compound|END_ENTITY	Antagonistic effects of leucine and glutamine on the mTOR pathway in myogenic C2C12 cells .
21702994	0	leucine	25,32	mTOR	36,40	leucine	mTOR	CHEBI:25017	21977(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|signalling signalling|compound|END_ENTITY	The actions of exogenous leucine on mTOR signalling and amino_acid transporters in human myotubes .
23563533	0	leucine	71,78	mTOR	30,34	leucine	mTOR	CHEBI:25017	21977(Tax:10090)	Chemical	Gene	response|nmod|START_ENTITY response|nmod|END_ENTITY	Differential dose response of mTOR signaling to oral administration of leucine in skeletal muscle and liver of rats .
24793303	0	leucine	82,89	mTOR	42,46	leucine	mTOR	CHEBI:25017	21977(Tax:10090)	Chemical	Gene	amino_acids|amod|START_ENTITY differs|nmod|amino_acids differs|nsubj|Requirement Requirement|nmod|localization localization|nmod|END_ENTITY	Requirement for lysosomal localization of mTOR for its activation differs between leucine and other amino_acids .
22898570	0	leucine	78,85	mTORC1	42,48	leucine	mTORC1	CHEBI:25017	382056(Tax:10090)	Chemical	Gene	catabolism|compound|START_ENTITY activation|nmod|catabolism activation|amod|END_ENTITY	Cellular signaling of amino_acids towards mTORC1 activation in impaired human leucine catabolism .
24476474	0	leucine	11,18	mTORC1	79,85	leucine	mTORC1	CHEBI:25017	382056(Tax:10090)	Chemical	Gene	Absence|nmod|START_ENTITY reduces|nsubj|Absence reduces|dobj|activation activation|nmod|signalling signalling|amod|END_ENTITY	Absence of leucine in an essential amino_acid supplement reduces activation of mTORC1 signalling following resistance exercise in young females .
25567907	1	leucine	49,56	mTORC1	39,45	leucine	mTORC1	CHEBI:25017	382056(Tax:10090)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of mTORC1 by leucine and glutamine .
26449471	0	leucine	14,21	mTORC1	37,43	leucine	mTORC1	CHEBI:25017	382056(Tax:10090)	Chemical	Gene	sensor|amod|START_ENTITY sensor|nmod|pathway pathway|amod|END_ENTITY	Sestrin2 is a leucine sensor for the mTORC1 pathway .
26530388	0	leucine	36,43	mTORC1	22,28	leucine	mTORC1	CHEBI:25017	382056(Tax:10090)	Chemical	Gene	START_ENTITY|nmod:npmod|senses senses|nummod|END_ENTITY	Cell signallling : How mTORC1 senses leucine .
11264169	0	leucine	14,21	mi_transcription_factor	39,62	leucine	mi transcription factor	CHEBI:25017	17342(Tax:10090)	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Importance of leucine zipper domain of mi_transcription_factor -LRB- MITF -RRB- for differentiation of mast cells demonstrated using mi -LRB- ce -RRB- / mi -LRB- ce -RRB- mutant mice of which MITF lacks the zipper domain .
11021659	0	leucine	48,55	mucin	88,93	leucine	mucin	CHEBI:25017	4589	Chemical	Gene	START_ENTITY|dobj|domain domain|nmod|END_ENTITY	Solution structure of O-glycosylated C-terminal leucine zipper domain of human salivary mucin -LRB- MUC7 -RRB- .
1328181	0	leucine	20,27	p40	11,14	leucine	p40	CHEBI:25017	3578	Chemical	Gene	protein|amod|START_ENTITY END_ENTITY|appos|protein	Studies on p40 , the leucine zipper motif-containing protein encoded by the first open reading frame of an active human LINE-1 transposable element .
12161423	0	leucine	140,147	secretoglobin_1a1	101,118	leucine	secretoglobin 1a1	CHEBI:25017	7356	Chemical	Gene	protein|nmod|START_ENTITY protein|appos|END_ENTITY	Synergistic transactivation of the differentiation-dependent lung gene Clara cell secretory protein -LRB- secretoglobin_1a1 -RRB- by the basic region leucine zipper factor CCAAT/enhancer-binding _ protein_alpha and the homeodomain factor Nkx2 .1 / thyroid_transcription_factor-1 .
17827227	0	leucine	63,70	upstream_stimulatory_factor_1	88,117	leucine	upstream stimulatory factor 1	CHEBI:25017	7391	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Low resolution structural models of the basic helix-loop-helix leucine zipper domain of upstream_stimulatory_factor_1 and its complexes with DNA from small angle X-ray scattering data .
23583714	0	leucines	4,12	SlMKK2	59,65	leucines	SlMKK2	null	543946(Tax:4081)	Chemical	Gene	START_ENTITY|nmod|site site|nmod|END_ENTITY	Two leucines in the N-terminal MAPK-docking site of tomato SlMKK2 are critical for interaction with a downstream MAPK to elicit programmed_cell_death associated with plant immunity .
15467766	0	leucovorin	67,77	CPT-11	45,51	leucovorin	CPT-11	MESH:D002955	963084(Tax:115711)	Chemical	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	Multicentre phase II study of bifractionated CPT-11 with bimonthly leucovorin and 5-fluorouracil in patients with metastatic_colorectal_cancer pretreated with FOLFOX .
12598341	0	leucovorin	74,84	interferon-alpha2b	139,157	leucovorin	interferon-alpha2b	MESH:D002955	3440	Chemical	Gene	evaluation|nmod|START_ENTITY evaluation|nmod|END_ENTITY	Surgical adjuvant therapy of rectal_carcinoma : a controlled evaluation of leucovorin , 5-fluorouracil and radiation_therapy with or without interferon-alpha2b .
10486239	0	leukosialin	12,23	CD43	25,29	leukosialin	CD43	MESH:D051917	24796(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	PECAM-1 and leukosialin -LRB- CD43 -RRB- expression correlate with heightened_inflammation in rat adjuvant-induced_arthritis .
1541817	0	leukosialin	14,25	CD43	27,31	leukosialin	CD43	MESH:D051917	20737(Tax:10090)	Chemical	Gene	Evidence|dep|START_ENTITY Evidence|appos|END_ENTITY	Evidence that leukosialin , CD43 , is intensely sulfated in the murine T_lymphoma line RDM-4 .
7831340	0	leukosialin	17,28	CD43	30,34	leukosialin	CD43	MESH:D051917	20737(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Disregulation of leukosialin -LRB- CD43 , Ly48 , sialophorin -RRB- expression in the B-cell lineage of transgenic_mice increases splenic B-cell number and survival .
8145025	0	leukosialin	33,44	CD43	27,31	leukosialin	CD43	MESH:D051917	24796(Tax:10116)	Chemical	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	Differential expression of CD43 -LRB- leukosialin , sialophorin -RRB- by mononuclear phagocyte populations .
25152163	0	leukotriene	33,44	5-Lipoxygenase	0,14	leukotriene	5-Lipoxygenase	CHEBI:25029	240	Chemical	Gene	biosynthesis|amod|START_ENTITY enzyme|nmod|biosynthesis END_ENTITY|appos|enzyme	5-Lipoxygenase , a key enzyme for leukotriene biosynthesis in health and disease .
7522524	0	leukotriene	62,73	Granulocyte_colony-stimulating_factor	0,37	leukotriene	Granulocyte colony-stimulating factor	CHEBI:25029	1440	Chemical	Gene	production|compound|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Granulocyte_colony-stimulating_factor inhibits the endogenous leukotriene production in tumour patients .
15145787	0	leukotriene	36,47	Leptin	0,6	leukotriene	Leptin	CHEBI:25029	16846(Tax:10090)	Chemical	Gene	synthesis|compound|START_ENTITY augments|dobj|synthesis augments|nsubj|END_ENTITY	Leptin augments alveolar_macrophage leukotriene synthesis by increasing phospholipase activity and enhancing group IVC iPLA2 -LRB- cPLA2gamma -RRB- protein expression .
17223000	0	leukotriene	29,40	MUC2/5AC	87,95	leukotriene	MUC2/5AC	CHEBI:25029	4583;4586	Chemical	Gene	receptor|amod|START_ENTITY effect|nmod|receptor antagonist|nsubj|effect antagonist|nmod|expression expression|compound|END_ENTITY	The inhibitory effect of the leukotriene receptor antagonist on leukotriene D4-induced MUC2/5AC gene expression and mucin secretion in human airway epithelial cells .
17223000	0	leukotriene	64,75	MUC2/5AC	87,95	leukotriene	MUC2/5AC	CHEBI:25029	4583;4586	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	The inhibitory effect of the leukotriene receptor antagonist on leukotriene D4-induced MUC2/5AC gene expression and mucin secretion in human airway epithelial cells .
8300592	0	leukotriene_A4	47,61	5-lipoxygenase	29,43	leukotriene A4	5-lipoxygenase	MESH:D017572	240	Chemical	Gene	inactivation|nmod|START_ENTITY inactivation|nmod|END_ENTITY	Irreversible inactivation of 5-lipoxygenase by leukotriene_A4 .
1846895	0	leukotriene_B4	76,90	Granulocyte-macrophage_colony-stimulating_factor	0,48	leukotriene B4	Granulocyte-macrophage colony-stimulating factor	MESH:D007975	1437	Chemical	Gene	synthesis|nmod|START_ENTITY increases|dobj|synthesis increases|nsubj|END_ENTITY	Granulocyte-macrophage_colony-stimulating_factor increases the synthesis of leukotriene_B4 by human neutrophils in response to platelet-activating factor .
17976189	0	leukotriene_B4	65,79	cytosolic_phospholipase_A2	18,44	leukotriene B4	cytosolic phospholipase A2	MESH:D007975	5321	Chemical	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	The expression of cytosolic_phospholipase_A2 and biosynthesis of leukotriene_B4 in acute_myeloid_leukemia cells .
12398766	0	leukotriene_C4	13,27	multidrug_resistance_protein_1	47,77	leukotriene C4	multidrug resistance protein 1	MESH:D017997	851948(Tax:4932)	Chemical	Gene	Transport|nmod|START_ENTITY Transport|nmod|END_ENTITY	Transport of leukotriene_C4 by a cysteine-less multidrug_resistance_protein_1 -LRB- MRP1 -RRB- .
15705997	0	leukotriene_e4	81,95	5-lipoxygenase	17,31	leukotriene e4	5-lipoxygenase	MESH:D017999	240	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|inhibitor inhibitor|amod|END_ENTITY	The effects of a 5-lipoxygenase inhibitor on acute_mountain_sickness and urinary leukotriene_e4 after ascent to high altitude .
16171799	0	leukotrienes	41,53	PPARgamma	82,91	leukotrienes	PPARgamma	MESH:D015289	25664(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Ciglitazone inhibits the antigen-induced leukotrienes production independently of PPARgamma in RBL-2H3 mast cells .
2443931	0	leukotrienes	107,119	alpha-fetoprotein	10,27	leukotrienes	alpha-fetoprotein	MESH:D015289	11576(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY Effect|dep|role Effect|nmod|END_ENTITY	Effect of alpha-fetoprotein and indomethacin on arachidonic_acid metabolism in P388D1 macrophages : role of leukotrienes .
2986134	0	leukotrienes	14,26	beta-glucan_receptor	72,92	leukotrienes	beta-glucan receptor	MESH:D015289	64581	Chemical	Gene	Generation|nmod|START_ENTITY Generation|nmod|END_ENTITY	Generation of leukotrienes by human monocytes upon stimulation of their beta-glucan_receptor during phagocytosis .
12016997	0	leukotrienes	12,24	interleukin_6	42,55	leukotrienes	interleukin 6	MESH:D015289	16193(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	-LSB- Effects of leukotrienes on production of interleukin_6 from mouse peritoneal macrophages -RSB- .
8985466	0	leupeptin	70,79	Cathepsin_B	0,11	leupeptin	Cathepsin B	MESH:C032854	64529(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|dep|effect	Cathepsin_B in the growth of colorectal_cancer : suppressive effect of leupeptin on the growth of DMH-induced rat colon_neoplasm .
21819703	0	leuprolide	95,105	GnRH	17,21	leuprolide	GnRH	MESH:D016729	2796	Chemical	Gene	agonist|appos|START_ENTITY effect|nmod|agonist blocks|dobj|effect blocks|nsubj|Silencing Silencing|nmod|receptor receptor|compound|END_ENTITY	Silencing of the GnRH type 1 receptor blocks the antiproliferative effect of the GnRH agonist , leuprolide , on the androgen-independent prostate_cancer cell line DU145 .
21819703	0	leuprolide	95,105	GnRH	81,85	leuprolide	GnRH	MESH:D016729	2796	Chemical	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	Silencing of the GnRH type 1 receptor blocks the antiproliferative effect of the GnRH agonist , leuprolide , on the androgen-independent prostate_cancer cell line DU145 .
7819707	0	leuprolide	67,77	GnRH	50,54	leuprolide	GnRH	MESH:D016729	2796	Chemical	Gene	Evaluation|dep|START_ENTITY Evaluation|nmod|analogues analogues|appos|END_ENTITY	Evaluation of two gonadotropin-releasing_hormone -LRB- GnRH -RRB- analogues -LRB- leuprolide and buserelin -RRB- in short and long protocols for assisted reproduction techniques .
11342922	0	leuprolide	115,125	gonadotropin-releasing_hormone	4,34	leuprolide	gonadotropin-releasing hormone	MESH:D016729	2796	Chemical	Gene	agonists|amod|START_ENTITY releasing|dobj|agonists hormone|acl|releasing depot|nmod|hormone depot|amod|END_ENTITY	The gonadotropin-releasing_hormone antagonist abarelix depot versus luteinizing hormone releasing hormone agonists leuprolide or goserelin : initial results of endocrinological and biochemical efficacies in patients with prostate_cancer .
20632397	0	leuprolide	98,108	gonadotropin-releasing_hormone	117,147	leuprolide	gonadotropin-releasing hormone	MESH:D016729	2796	Chemical	Gene	analogs|amod|START_ENTITY analogs|amod|END_ENTITY	Enzymatic stability , solution structure , and antiproliferative effect on prostate_cancer cells of leuprolide and new gonadotropin-releasing_hormone peptide analogs .
21534336	0	leuprolide	63,73	gonadotropin-releasing_hormone	14,44	leuprolide	gonadotropin-releasing hormone	MESH:D016729	2796	Chemical	Gene	effect|appos|START_ENTITY effect|nmod|treatment treatment|amod|END_ENTITY	The effect of gonadotropin-releasing_hormone analog treatment -LRB- leuprolide -RRB- on body fat distribution in idiopathic_central_precocious_puberty .
21788033	0	leuprolide	56,66	gonadotropin-releasing_hormone	95,125	leuprolide	gonadotropin-releasing hormone	MESH:D016729	2796	Chemical	Gene	crossover|nmod|START_ENTITY trial|nmod|crossover trial|dep|comparison comparison|nmod|agonist agonist|amod|END_ENTITY	A phase III extension trial with a 1-arm crossover from leuprolide to degarelix : comparison of gonadotropin-releasing_hormone agonist and antagonist effect on prostate_cancer .
2474565	0	leuprolide	61,71	gonadotropin-releasing_hormone	22,52	leuprolide	gonadotropin-releasing hormone	MESH:D016729	2796	Chemical	Gene	Effect|appos|START_ENTITY Effect|nmod|analog analog|amod|END_ENTITY	Effect of long-acting gonadotropin-releasing_hormone analog -LRB- leuprolide -RRB- therapy on prostatic size and symptoms in 15 men with benign_prostatic_hypertrophy .
2511532	0	leuprolide	79,89	gonadotropin-releasing_hormone	38,68	leuprolide	gonadotropin-releasing hormone	MESH:D016729	2796	Chemical	Gene	trial|appos|START_ENTITY trial|nmod|analogue analogue|amod|END_ENTITY	A placebo-controlled trial of a depot gonadotropin-releasing_hormone analogue -LRB- leuprolide -RRB- in the treatment of uterine_leiomyomata .
2515234	0	leuprolide	89,99	gonadotropin-releasing_hormone	50,80	leuprolide	gonadotropin-releasing hormone	MESH:D016729	2796	Chemical	Gene	START_ENTITY|nsubj|Effectiveness Effectiveness|nmod|suppression suppression|nmod|agonist agonist|amod|END_ENTITY	Effectiveness of short pituitary suppression with gonadotropin-releasing_hormone agonist leuprolide during induction of ovulation for in vitro fertilization .
3115833	0	leuprolide	57,67	gonadotropin-releasing_hormone	71,101	leuprolide	gonadotropin-releasing hormone	MESH:D016729	2796	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Treatment_of_leiomyomata with intranasal or subcutaneous leuprolide , a gonadotropin-releasing_hormone agonist .
3123281	0	leuprolide	57,67	gonadotropin-releasing_hormone	18,48	leuprolide	gonadotropin-releasing hormone	MESH:D016729	2796	Chemical	Gene	START_ENTITY|nsubj|use use|nmod|agonist agonist|amod|END_ENTITY	Successful use of gonadotropin-releasing_hormone agonist leuprolide for in vitro fertilization in a patient with polycystic_ovarian_disease and infertility unresponsive to standard treatment .
3146612	0	leuprolide	58,68	gonadotropin-releasing_hormone	18,48	leuprolide	gonadotropin-releasing hormone	MESH:D016729	2796	Chemical	Gene	use|appos|START_ENTITY use|nmod|agonist agonist|amod|END_ENTITY	Short-term use of gonadotropin-releasing_hormone agonist -LRB- leuprolide -RRB- for in_vitro_fertilization .
3918377	0	leuprolide	76,86	gonadotropin-releasing_hormone	44,74	leuprolide	gonadotropin-releasing hormone	MESH:D016729	2796	Chemical	Gene	Evaluation|appos|START_ENTITY Evaluation|nmod|analogue analogue|nmod|END_ENTITY	Evaluation of synthetic agonist analogue of gonadotropin-releasing_hormone -LRB- leuprolide -RRB- on testicular androgen production in patients with carcinoma_of_prostate .
7819707	0	leuprolide	67,77	gonadotropin-releasing_hormone	18,48	leuprolide	gonadotropin-releasing hormone	MESH:D016729	2796	Chemical	Gene	Evaluation|dep|START_ENTITY Evaluation|nmod|analogues analogues|amod|END_ENTITY	Evaluation of two gonadotropin-releasing_hormone -LRB- GnRH -RRB- analogues -LRB- leuprolide and buserelin -RRB- in short and long protocols for assisted reproduction techniques .
6402584	0	leuprolide	79,89	luteinizing_hormone-releasing_hormone	31,68	leuprolide	luteinizing hormone-releasing hormone	MESH:D016729	25194(Tax:10116)	Chemical	Gene	analogue|appos|START_ENTITY analogue|amod|END_ENTITY	Vaginal absorption of a potent luteinizing_hormone-releasing_hormone analogue -LRB- leuprolide -RRB- in rats II : mechanism of absorption enhancement with organic acids .
6403230	0	leuprolide	93,103	luteinizing_hormone-releasing_hormone	45,82	leuprolide	luteinizing hormone-releasing hormone	MESH:D016729	25194(Tax:10116)	Chemical	Gene	analogue|appos|START_ENTITY analogue|amod|END_ENTITY	Regression of rat mammary_tumors by a potent luteinizing_hormone-releasing_hormone analogue -LRB- leuprolide -RRB- administered vaginally .
6403693	0	leuprolide	79,89	luteinizing_hormone-releasing_hormone	31,68	leuprolide	luteinizing hormone-releasing hormone	MESH:D016729	25194(Tax:10116)	Chemical	Gene	analogue|appos|START_ENTITY analogue|amod|END_ENTITY	Vaginal absorption of a potent luteinizing_hormone-releasing_hormone analogue -LRB- leuprolide -RRB- in rats III : Effect of estrous cycle on vaginal absorption of hydrophilic model compounds .
6818337	0	leuprolide	77,87	luteinizing_hormone-releasing_hormone	31,68	leuprolide	luteinizing hormone-releasing hormone	MESH:D016729	25194(Tax:10116)	Chemical	Gene	analog|appos|START_ENTITY analog|amod|END_ENTITY	Vaginal absorption of a potent luteinizing_hormone-releasing_hormone analog -LRB- leuprolide -RRB- in rats I : absorption by various routes and absorption enhancement .
10640887	0	leuprolide_acetate	85,103	GnRH	72,76	leuprolide acetate	GnRH	MESH:D016729	2796	Chemical	Gene	START_ENTITY|nsubj|evaluation evaluation|nmod|suppression suppression|nmod|agonist agonist|compound|END_ENTITY	Auxological and biochemical evaluation of pubertal suppression with the GnRH agonist leuprolide_acetate in early and precocious puberty .
22901846	0	leuprolide_acetate	46,64	GnRH	32,36	leuprolide acetate	GnRH	MESH:D016729	2796	Chemical	Gene	START_ENTITY|amod|Gonadotropin-releasing_hormone Gonadotropin-releasing_hormone|dep|END_ENTITY	Gonadotropin-releasing_hormone -LRB- GnRH -RRB- agonist leuprolide_acetate and GnRH antagonist cetrorelix_acetate directly inhibit leiomyoma extracellular matrix production .
2496961	0	leuprolide_acetate	54,72	GnRH	106,110	leuprolide acetate	GnRH	MESH:D016729	2796	Chemical	Gene	START_ENTITY|appos|analog analog|appos|END_ENTITY	Debilitating `` functional '' bowel_disease controlled by leuprolide_acetate , gonadotropin-releasing_hormone -LRB- GnRH -RRB- analog .
1899400	0	leuprolide_acetate	40,58	Gonadotropin-releasing_hormone	0,30	leuprolide acetate	Gonadotropin-releasing hormone	MESH:D016729	2796	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Gonadotropin-releasing_hormone agonist -LRB- leuprolide_acetate -RRB- induced ovarian_hyperstimulation_syndrome in a woman undergoing intermittent hemodialysis .
2570847	0	leuprolide_acetate	36,54	LHRH	22,26	leuprolide acetate	LHRH	MESH:D016729	25194(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	Controlled release of LHRH agonist , leuprolide_acetate , from microcapsules : serum drug level profiles and pharmacological effects in animals .
16133689	0	leuprolide_acetate	187,205	gonadotropin-releasing_hormone	90,120	leuprolide acetate	gonadotropin-releasing hormone	MESH:D016729	2796	Chemical	Gene	buserelin_acetate|nmod|START_ENTITY comparison|nmod|buserelin_acetate effects|dep|comparison effects|nmod|metabolism metabolism|nmod|treatment treatment|nmod|analogues analogues|amod|END_ENTITY	Long-term effects on bone_mineral_density and bone metabolism of 6 months ' treatment with gonadotropin-releasing_hormone analogues in Japanese women : comparison of buserelin_acetate with leuprolide_acetate .
2496961	0	leuprolide_acetate	54,72	gonadotropin-releasing_hormone	74,104	leuprolide acetate	gonadotropin-releasing hormone	MESH:D016729	2796	Chemical	Gene	START_ENTITY|appos|analog analog|amod|END_ENTITY	Debilitating `` functional '' bowel_disease controlled by leuprolide_acetate , gonadotropin-releasing_hormone -LRB- GnRH -RRB- analog .
2507570	0	leuprolide_acetate	94,112	gonadotropin-releasing_hormone	55,85	leuprolide acetate	gonadotropin-releasing hormone	MESH:D016729	2796	Chemical	Gene	analog|appos|START_ENTITY analog|amod|END_ENTITY	Suppression of gonadotropin secretion by a long-acting gonadotropin-releasing_hormone analog -LRB- leuprolide_acetate , Lupron Depot -RRB- in children with precocious puberty .
7507123	0	leuprolide_acetate	7,25	gonadotropin-releasing_hormone	110,140	leuprolide acetate	gonadotropin-releasing hormone	MESH:D016729	2796	Chemical	Gene	patterns|amod|START_ENTITY Use|nmod|patterns Use|dep|comparison comparison|nmod|test test|amod|END_ENTITY	Use of leuprolide_acetate response patterns in the early diagnosis of pubertal_disorders : comparison with the gonadotropin-releasing_hormone test .
9195202	0	leuprolide_acetate	87,105	gonadotropin-releasing_hormone	48,78	leuprolide acetate	gonadotropin-releasing hormone	MESH:D016729	2796	Chemical	Gene	START_ENTITY|nsubj|Effectiveness Effectiveness|nmod|use use|nmod|agonist agonist|amod|END_ENTITY	Effectiveness and limitations of the use of the gonadotropin-releasing_hormone agonist leuprolide_acetate in the diagnosis of delayed puberty in males .
9543151	0	leuprolide_acetate	125,143	gonadotropin-releasing_hormone	85,115	leuprolide acetate	gonadotropin-releasing hormone	MESH:D016729	2796	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Suppression of cell proliferation and induction of apoptosis in uterine leiomyoma by gonadotropin-releasing_hormone agonist -LRB- leuprolide_acetate -RRB- .
2105242	0	leuprolide_acetate	130,148	growth_hormone	14,28	leuprolide acetate	growth hormone	MESH:D016729	2688	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|END_ENTITY	Fasting serum growth_hormone and insulin-like_growth_factor-I and - II concentrations in women with leiomyomata uteri treated with leuprolide_acetate or placebo .
3126294	0	leuprolide_acetate	95,113	luteinizing_hormone-releasing_hormone	48,85	leuprolide acetate	luteinizing hormone-releasing hormone	MESH:D016729	25194(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	One-month release injectable microcapsules of a luteinizing_hormone-releasing_hormone agonist -LRB- leuprolide_acetate -RRB- for treating experimental endometriosis in rats .
11903688	0	leuprorelin_acetate	13,32	GnRH	0,4	leuprorelin acetate	GnRH	CHEBI:63597	25194(Tax:10116)	Chemical	Gene	analog|appos|START_ENTITY analog|amod|END_ENTITY	GnRH analog , leuprorelin_acetate , promotes regeneration of rat spermatogenesis after severe chemical damage .
15128054	7	levamisole	1166,1176	IL-6	1069,1073	levamisole	IL-8	MESH:D007978	3576	Chemical	Gene	treated|nmod|START_ENTITY treated|nmod|END_ENTITY	Eighty-two RAU patients , with the serum IL-6 or IL-8 levels higher than the upper limit of normal serum concentration , were treated with levamisole for 0.5-3 .5 months , and their serum IL-6 and IL-8 levels were measured after treatment .
618069	0	levamisole	14,24	LIF	57,60	levamisole	LIF	MESH:D007978	3976	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|production production|compound|END_ENTITY	The effect of levamisole on leukocyte_inhibiting_factor -LRB- LIF -RRB- production `` in vitro '' .
7005756	0	levamisole	119,129	LIF	47,50	levamisole	LIF	MESH:D007978	3976	Chemical	Gene	Evaluation|nmod|START_ENTITY Evaluation|nmod|inhibition inhibition|appos|END_ENTITY	-LSB- Evaluation of leukocyte migration inhibition -LRB- LIF -RRB- in patients with carcinoma_of_the_lung before and after the use of levamisole in vitro -RSB- .
11064385	0	levamisole	116,126	TNM	144,147	levamisole	TNM	MESH:D007978	10178	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	Preliminary analysis of a randomized clinical trial of adjuvant postoperative RT vs. postoperative RT plus 5-FU and levamisole in patients with TNM stage II-III resectable rectal_cancer .
8288857	0	levamisole	14,24	acetylcholinesterase	28,48	levamisole	acetylcholinesterase	MESH:D007978	11423(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	The effect of levamisole on acetylcholinesterase secretion by male and female Heligmosomoides polygyrus during ageing .
2579492	0	levamisole	11,21	alpha_2-macroglobulin	25,46	levamisole	alpha 2-macroglobulin	MESH:D007978	232345(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	-LSB- Effect of levamisole on alpha_2-macroglobulin and lysozyme levels in the trachea , peritoneal exudate and serum of mice -RSB- .
618069	0	levamisole	14,24	leukocyte_inhibiting_factor	28,55	levamisole	leukocyte inhibiting factor	MESH:D007978	3976	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|production production|amod|END_ENTITY	The effect of levamisole on leukocyte_inhibiting_factor -LRB- LIF -RRB- production `` in vitro '' .
21187108	0	levetiracetam	115,128	beta-endorphin	41,55	levetiracetam	beta-endorphin	MESH:C026098	5443	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|levels levels|compound|END_ENTITY	Voluntary_alcohol_consumption and plasma beta-endorphin levels in alcohol preferring rats chronically treated with levetiracetam : a preliminary study .
17408599	0	levetiracetam	10,23	glutamate_and_GABA_transporters	63,94	levetiracetam	glutamate and GABA transporters	MESH:C026098	29483(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of levetiracetam on molecular regulation of hippocampal glutamate_and_GABA_transporters in rats with chronic seizures induced by amygdalar FeCl3 injection .
25124896	0	levobupivacaine	53,68	P2X7	0,4	levobupivacaine	P2X7	MESH:C476513	5027	Chemical	Gene	effects|nmod|START_ENTITY involved|nmod|effects involved|nsubjpass|END_ENTITY	P2X7 is involved in the anti-inflammation effects of levobupivacaine .
8911706	0	levocabastine	15,28	ICAM-1	37,43	levocabastine	ICAM-1	MESH:C047340	3383	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|compound|END_ENTITY	Topical ocular levocabastine reduces ICAM-1 expression on epithelial cells both in vivo and in vitro .
26972400	0	levocarnitine	10,23	TIMP-1	27,33	levocarnitine	TIMP-1	MESH:D002331	116510(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of levocarnitine on TIMP-1 , ICAM-1 expression of rats with coronary_heart_disease and its myocardial protection effect .
24982238	0	levocetirizine	21,35	RANTES	85,91	levocetirizine	RANTES	MESH:C472067	6352	Chemical	Gene	action|nmod|START_ENTITY END_ENTITY|nsubj|action	Inhibitory action of levocetirizine on the production of eosinophil chemoattractants RANTES and eotaxin in vitro and in vivo .
63787	0	levodopa	41,49	Growth-hormone	0,14	levodopa	Growth-hormone	MESH:D007980	2688	Chemical	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Growth-hormone and prolactin response to levodopa in affective illness .
4112206	0	levodopa	56,64	Prolactin	0,9	levodopa	Prolactin	MESH:D007980	5617	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|dep|effect	Prolactin , F.S.H. , and L.H. in breast_cancer : effect of levodopa and oophorectomy .
17300811	0	levofloxacin	23,35	IL-1beta	66,74	levofloxacin	IL-1beta	MESH:D015242	16176(Tax:10090)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|production production|compound|END_ENTITY	Biphasic regulation of levofloxacin on lipopolysaccharide-induced IL-1beta production .
17713325	0	levofloxacin	11,23	interleukin-6	43,56	levofloxacin	interleukin-6	MESH:D015242	3569	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|production production|amod|END_ENTITY	Effects of levofloxacin and doxycycline on interleukin-6 production of Chlamydia_trachomatis-infected human synovial fibroblasts .
6428124	0	levonorgestrel	81,95	luteinizing_hormone_releasing_hormone	16,53	levonorgestrel	luteinizing hormone releasing hormone	MESH:D016912	25194(Tax:10116)	Chemical	Gene	agonist|amod|START_ENTITY agonist|amod|END_ENTITY	The effect of a luteinizing_hormone_releasing_hormone -LRB- LRH -RRB- agonist -LRB- Wy-40 ,972 -RRB- , levonorgestrel , danazol and ovariectomy on experimental endometriosis in the rat .
25960207	0	levonorgestrel	81,95	miRNA-197	11,20	levonorgestrel	miRNA-197	MESH:D016912	406974	Chemical	Gene	overexpression|nmod|START_ENTITY overexpression|amod|END_ENTITY	Effects of miRNA-197 overexpression on proliferation , apoptosis and migration in levonorgestrel treated uterine leiomyoma cells .
19539144	0	levosimendan	50,62	B-type_natriuretic_peptide	8,34	levosimendan	B-type natriuretic peptide	MESH:C076731	4879	Chemical	Gene	treatment|compound|START_ENTITY response|nmod|treatment END_ENTITY|nmod|response	Lowered B-type_natriuretic_peptide in response to levosimendan or dobutamine treatment is associated with improved survival in patients with severe acutely_decompensated_heart_failure .
19861257	0	levosimendan	11,23	B-type_natriuretic_peptide	27,53	levosimendan	B-type natriuretic peptide	MESH:C076731	4879	Chemical	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	-LSB- Effect of levosimendan on B-type_natriuretic_peptide levels in patients with advanced heart_failure : a meta-analysis -RSB- .
22735864	0	levosimendan	11,23	TNF-alpha	27,36	levosimendan	TNF-alpha	MESH:C076731	7124	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of levosimendan on TNF-alpha , BNP and MMP-1 in patients with heart_failure with anemia .
19415994	0	levothyroxine	64,77	leptin	6,12	levothyroxine	leptin	MESH:D013974	3952	Chemical	Gene	treatment|amod|START_ENTITY effect|nmod|treatment END_ENTITY|dep|effect	Serum leptin in overt and subclinical_hypothyroidism : effect of levothyroxine treatment and relationship to menopausal status and body composition .
16046585	0	levothyroxine	69,82	osteoprotegerin	36,51	levothyroxine	osteoprotegerin	MESH:D013974	4982	Chemical	Gene	START_ENTITY|nsubj|Changes Changes|nmod|concentrations concentrations|nmod|END_ENTITY	Changes in plasma concentrations of osteoprotegerin before and after levothyroxine replacement therapy in hypothyroid patients .
15831782	0	levovirin_valinate_hydrochloride	46,78	R1518	80,85	levovirin valinate hydrochloride	R1518	MESH:C502685	176020(Tax:6239)	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY pharmacokinetics|appos|END_ENTITY	Single - and multiple-dose pharmacokinetics of levovirin_valinate_hydrochloride -LRB- R1518 -RRB- in healthy volunteers .
25055998	0	licochalcone_A	8,22	thymic_stromal_lymphopoietin	26,54	licochalcone A	thymic stromal lymphopoietin	MESH:C070840	85480	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Role of licochalcone_A on thymic_stromal_lymphopoietin expression : Implications for asthma .
20596749	0	lidamycin	55,64	Oct4	123,127	lidamycin	Oct4	MESH:C058024	100846986	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nsubj|END_ENTITY	Inhibition of mouse embryonic_carcinoma cell growth by lidamycin through down-regulation of embryonic stem cell-like genes Oct4 , Sox2 and Myc .
17534142	0	lidamycin	51,60	P53	0,3	lidamycin	P53	MESH:C058024	7157	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|apoptosis apoptosis|amod|END_ENTITY	P53 dependent and independent apoptosis induced by lidamycin in human colorectal_cancer cells .
21348302	0	lidamycin	51,60	TRAIL	81,86	lidamycin	TRAIL	MESH:C058024	8743	Chemical	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	-LSB- Synergistic effect and its possible mechanisms of lidamycin in combination with TRAIL in NSCLC -RSB- .
17487403	0	lidamycin	48,57	nuclear_factor-kappaB	23,44	lidamycin	nuclear factor-kappaB	MESH:C058024	4790	Chemical	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|nmod|END_ENTITY	Down-regulation of the nuclear_factor-kappaB by lidamycin in association with inducing apoptosis in human pancreatic_cancer cells and inhibiting xenograft growth .
8301634	0	lidocaine	11,20	CGRP	58,62	lidocaine	CGRP	MESH:D008012	796	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of lidocaine and calcitonin_gene-related_peptide -LRB- CGRP -RRB- on isolated human radial arteries .
3930047	0	lidocaine	16,25	CO2	47,50	lidocaine	CO2	MESH:D008012	717	Chemical	Gene	protein|amod|START_ENTITY protein|nmod|END_ENTITY	Modification of lidocaine protein binding with CO2 .
9750601	0	lidocaine	37,46	CO2	12,15	lidocaine	CO2	MESH:D008012	717	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	-LSB- Effects of CO2 and adrenaline on 1 % lidocaine in axillary block -RSB- .
24371375	3	lidocaine	309,318	HMGB1	361,366	lidocaine	HMGB1	MESH:D008012	25459(Tax:10116)	Chemical	Gene	has|nsubj|START_ENTITY has|dobj|effects effects|nmod|high_mobility_group_box_1 high_mobility_group_box_1|appos|END_ENTITY	However , it is unknown whether lidocaine has effects on high_mobility_group_box_1 -LRB- HMGB1 -RRB- , a key mediator of inflammation .
25419374	0	lidocaine	24,33	HMGB1	61,66	lidocaine	HMGB1	MESH:D008012	3146	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Intraoperative systemic lidocaine inhibits the expression of HMGB1 in patients undergoing radical hysterectomy .
3813168	0	lidocaine	43,52	Methemoglobin	0,13	lidocaine	Methemoglobin	MESH:D008012	3048	Chemical	Gene	administration|compound|START_ENTITY levels|nmod|administration levels|compound|END_ENTITY	Methemoglobin levels following intravenous lidocaine administration .
17445919	0	lidocaine	24,33	SCN5A	60,65	lidocaine	SCN5A	MESH:D008012	6331	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	A paradoxical effect of lidocaine for the N406S mutation of SCN5A associated with Brugada_syndrome .
19260480	0	lidocaine	130,139	TACE	0,4	lidocaine	TACE	MESH:D008012	6868	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|dep|effect	TACE of liver metastases from colorectal_cancer adopting irinotecan-eluting beads : beneficial effect of palliative intra-arterial lidocaine and post-procedure supportive therapy on the control of side effects .
19622790	0	lidocaine	73,82	TREK1	47,52	lidocaine	TREK1	MESH:D008012	3776	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of human two-pore domain K + channel TREK1 by local anesthetic lidocaine : negative cooperativity and half-of-sites saturation kinetics .
26972404	0	lidocaine	30,39	TRPV1	10,15	lidocaine	TRPV1	MESH:D008012	7442	Chemical	Gene	combined|nmod|START_ENTITY combined|nsubj|Effect Effect|nmod|END_ENTITY	Effect of TRPV1 combined with lidocaine on cell state and apoptosis of U87-MG glioma cell lines .
12721427	0	lidocaine	10,19	albumin	41,48	lidocaine	albumin	MESH:D008012	213	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of lidocaine on ovalbumin and egg albumin foam stability .
12721427	3	lidocaine	402,411	albumin	415,422	lidocaine	albumin	MESH:D008012	213	Chemical	Gene	effect|nmod|START_ENTITY study|dobj|effect study|nmod|foam foam|compound|END_ENTITY	Here , we study the effect of lidocaine on albumin foam , since drugs like lidocaine are known to bind with albumin .
12721427	3	lidocaine	446,455	albumin	415,422	lidocaine	albumin	MESH:D008012	213	Chemical	Gene	drugs|nmod|START_ENTITY known|nsubjpass|drugs study|advcl|known study|nmod|foam foam|compound|END_ENTITY	Here , we study the effect of lidocaine on albumin foam , since drugs like lidocaine are known to bind with albumin .
17179255	0	lidocaine	15,24	caspase_3	74,83	lidocaine	caspase 3	MESH:D008012	25402(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	The effects of lidocaine and bupivacaine on protein expression of cleaved caspase_3 and tyrosine phosphorylation in the rat hippocampal slice .
16551906	0	lidocaine	32,41	epidermal_growth_factor_receptor	106,138	lidocaine	epidermal growth factor receptor	MESH:D008012	1956	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|nmod|END_ENTITY	The antiproliferative effect of lidocaine on human tongue_cancer cells with inhibition of the activity of epidermal_growth_factor_receptor .
21288974	0	lidocaine	25,34	high_mobility_group_box_1	53,78	lidocaine	high mobility group box 1	MESH:D008012	15289(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|release release|nmod|END_ENTITY	The inhibitory effect of lidocaine on the release of high_mobility_group_box_1 in lipopolysaccharide-stimulated macrophages .
25669860	0	lidocaine	37,46	interleukin-6	66,79	lidocaine	interleukin-6	MESH:D008012	3569	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of intraoperative intravenous lidocaine on pain and plasma interleukin-6 in patients undergoing hysterectomy .
10834783	0	lidocaine	20,29	superoxide_dismutase	43,63	lidocaine	superoxide dismutase	MESH:D008012	6647	Chemical	Gene	treatment|compound|START_ENTITY treatment|nmod|END_ENTITY	Effect of high-dose lidocaine treatment on superoxide_dismutase and malon dialdehyde levels in seven diabetic patients .
7398761	0	lidoflazine	30,41	Ca2	14,17	lidoflazine	Ca2	MESH:D008013	760	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|antagonist antagonist|amod|END_ENTITY	Effect of the Ca2 + antagonist lidoflazine on normoxic and anoxic contractions of canine coronary arterial smooth muscle .
24568887	0	lignan_enterolactone	44,64	ABCG2	8,13	lignan enterolactone	ABCG2	null	9429	Chemical	Gene	transport|nmod|START_ENTITY Role|nmod|transport Role|nmod|END_ENTITY	Role of ABCG2 in transport of the mammalian lignan_enterolactone and its secretion into milk in Abcg2 knockout mice .
22575748	0	lignan_glucosides	4,21	tyrosinase	27,37	lignan glucosides	tyrosinase	null	7299	Chemical	Gene	START_ENTITY|nmod|activities activities|amod|END_ENTITY	New lignan_glucosides with tyrosinase inhibitory activities from exocarp of Castanea henryi .
24583784	0	lignan_glycosides	10,27	IL-6	33,37	lignan glycosides	IL-6	null	3569	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Three new lignan_glycosides with IL-6 inhibitory activity from Akebia quinata .
7720527	0	lignan_lactone	60,74	5-lipoxygenase	75,89	lignan lactone	5-lipoxygenase	null	240	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	In vitro and in vivo biotransformations of the naphthalenic lignan_lactone 5-lipoxygenase inhibitor , L-702 ,539 .
7490559	0	lignans	91,98	5_alpha-reductase	14,31	lignans	5 alpha-reductase	MESH:D017705	6715	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of 5_alpha-reductase in genital skin fibroblasts and prostate tissue by dietary lignans and isoflavonoids .
8540756	0	lignans	97,104	DNA_polymerase-alpha	62,82	lignans	DNA polymerase-alpha	MESH:D017705	5422	Chemical	Gene	activities|nmod|START_ENTITY activities|amod|END_ENTITY	Differential inhibition of reverse transcriptase and cellular DNA_polymerase-alpha activities by lignans isolated from Chinese herbs , Phyllanthus myrtifolius Moon , and tannins from Lonicera japonica Thunb and Castanopsis hystrix .
19452436	0	lignans	81,88	NQO1	48,52	lignans	NQO1	MESH:D017705	18104(Tax:10090)	Chemical	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	Induction of the phase II detoxification enzyme NQO1 in hepatocarcinoma cells by lignans from the fruit of Schisandra chinensis through nuclear accumulation of Nrf2 .
15305043	0	lignans	34,41	caspase-3	12,21	lignans	caspase-3	MESH:D017705	836	Chemical	Gene	Increase|nmod|START_ENTITY Increase|nmod|activity activity|amod|END_ENTITY	Increase of caspase-3 activity by lignans from Machilus thunbergii in HL-60 cells .
15967416	0	lignans	17,24	hypoxia-inducible_factor-1	62,88	lignans	hypoxia-inducible factor-1	MESH:D017705	3091	Chemical	Gene	START_ENTITY|dep|inhibitors inhibitors|nmod|END_ENTITY	Saururus cernuus lignans -- potent small molecule inhibitors of hypoxia-inducible_factor-1 .
15366838	0	lignans	22,29	matrix_metalloproteinase_7	55,81	lignans	matrix metalloproteinase 7	MESH:D017705	4316	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Inhibitory effects of lignans on the activity of human matrix_metalloproteinase_7 -LRB- matrilysin -RRB- .
9463941	0	lignans	15,22	sex_hormone_binding_globulin	34,62	lignans	sex hormone binding globulin	MESH:D017705	6462	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of lignans with human sex_hormone_binding_globulin -LRB- SHBG -RRB- .
21410687	0	ligustilide	26,37	RTP801	134,140	ligustilide	RTP801	MESH:C027820	140942(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Neuroprotective effect of ligustilide against ischaemia-reperfusion injury via up-regulation of erythropoietin and down-regulation of RTP801 .
15363138	0	ligustrazine	12,24	CD31	50,54	ligustrazine	CD31	MESH:C017953	18613(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of ligustrazine on expression of PECAM-1 / CD31 and hematopoietic reconstitution in syngenic bone marrow transplantation of mice -RSB- .
16463659	0	ligustrazine	21,33	CD31	51,55	ligustrazine	CD31	MESH:C017953	18613(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Enhancing effects of ligustrazine on expression of CD31 and hematopoietic reconstitution in syngenic bone marrow transplantation of mice .
11367642	0	ligustrazine	11,23	CD34	27,31	ligustrazine	CD34	MESH:C017953	12490(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	-LSB- Effect of ligustrazine on CD34 antigen expression of bone marrow cells in immune-mediated aplastic_anemia mice -RSB- .
15228650	0	ligustrazine	15,27	CD44	49,53	ligustrazine	CD44	MESH:C017953	12505(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- The effect of ligustrazine on the expression of CD44 in bone marrow of bone marrow transplantation mice -RSB- .
12840848	0	ligustrazine	10,22	CD49d	58,63	ligustrazine	CD49d	MESH:C017953	16401(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of ligustrazine on expression of adherent molecule CD49d and cyclin_D2 in hematopoietic cells in acute radiation injured mice .
15315336	0	ligustrazine	10,22	ICAM-1	51,57	ligustrazine	ICAM-1	MESH:C017953	15894(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of ligustrazine on the expression of LFA-1 , ICAM-1 following bone marrow transplantation in mice .
15157328	0	ligustrazine	11,23	LFA-1	45,50	ligustrazine	LFA-1	MESH:C017953	16408(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of ligustrazine on the expression of LFA-1 and ICAM-1 in bone marrow transplantation recipient mice -RSB- .
21179790	0	ligustrazine	46,58	NSE	22,25	ligustrazine	NSE	MESH:C017953	24334(Tax:10116)	Chemical	Gene	Changes|nmod|START_ENTITY Changes|nmod|END_ENTITY	-LSB- Changes of the brain NSE , S100 and effect of ligustrazine in rats of chronic hypoxia and hypercapnia -RSB- .
15748429	0	ligustrazine	12,24	VCAM-1	42,48	ligustrazine	VCAM-1	MESH:C017953	22329(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of ligustrazine on expression of VCAM-1 / VLA-4 in syngenic bone marrow transplantation of mice -RSB- .
17096907	0	ligustrazine	11,23	bFGF	45,49	ligustrazine	bFGF	MESH:C017953	14173(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of ligustrazine on the expression of bFGF in bone marrow stromal cells of mice after BMT -RSB- .
21180165	0	ligustrazine	11,23	heme_oxygenase-1	58,74	ligustrazine	heme oxygenase-1	MESH:C017953	100008919(Tax:9986)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of ligustrazine on the expression and activity of heme_oxygenase-1 in the pulmonary_ischemia / reperfusion injury in rabbits -RSB- .
11775908	0	ligustrazine	23,35	intercellular_cell_adhesion_molecule-1	57,95	ligustrazine	intercellular cell adhesion molecule-1	MESH:C017953	3383	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|cells cells|amod|END_ENTITY	-LSB- Inhibitory effects of ligustrazine on the expression of intercellular_cell_adhesion_molecule-1 , vascular_cell_adhesion_molecule-1 in human umbilical vein endothelial cells induced by preeclamptic plasma -RSB- .
11775908	0	ligustrazine	23,35	vascular_cell_adhesion_molecule-1	97,130	ligustrazine	vascular cell adhesion molecule-1	MESH:C017953	7412	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|cells cells|amod|END_ENTITY	-LSB- Inhibitory effects of ligustrazine on the expression of intercellular_cell_adhesion_molecule-1 , vascular_cell_adhesion_molecule-1 in human umbilical vein endothelial cells induced by preeclamptic plasma -RSB- .
23883159	0	limestone	67,76	CO2	44,47	limestone	CO2	MESH:D002119	717	Chemical	Gene	capture|nmod|START_ENTITY capture|compound|END_ENTITY	Acoustic streaming enhances the Multicyclic CO2 capture of natural limestone at Ca-looping conditions .
20492298	5	limonene	714,722	MCP-1	734,739	limonene	MG132	MESH:C008281	875581(Tax:243273)	Chemical	Gene	production|amod|START_ENTITY production|compound|END_ENTITY	14.68 mmol/L concentration of limonene diminished MCP-1 production via NF-kappa_B activation comparable to the addition of the proteasomal inhibitor MG132 .
27030509	11	limonene	1261,1269	TRPA1	1238,1243	limonene	TRPA1	MESH:C008281	277328(Tax:10090)	Chemical	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	Heterologously expressed mouse TRPA1 was activated by limonene .
19782062	0	limonin	41,48	P-glycoprotein	14,28	limonin	P-glycoprotein	MESH:C001546	5243	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Inhibition of P-glycoprotein activity by limonin and other secondary metabolites from Citrus species in human colon_and_leukaemia cell lines .
22001672	0	limonin	22,29	cytochrome_P450	43,58	limonin	cytochrome P450	MESH:C001546	4051	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|enzymes enzymes|amod|END_ENTITY	Inhibitory effects of limonin on six human cytochrome_P450 enzymes and P-glycoprotein in vitro .
21924259	0	limonoids	43,52	p38	56,59	limonoids	p38	MESH:D036701	1432	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Structure-function relationships of citrus limonoids on p38 MAP kinase activity in human aortic smooth muscle cells .
19552619	0	linagliptin	122,133	DPP-4	106,111	linagliptin	DPP-4	MESH:C568794	1803	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|Evaluation Evaluation|nmod|potential potential|nmod|interactions interactions|nmod|END_ENTITY	Evaluation of the potential for steady-state pharmacokinetic and pharmacodynamic interactions between the DPP-4 inhibitor linagliptin and metformin in healthy subjects .
19771584	0	linagliptin	64,75	DPP-4	105,110	linagliptin	DPP-4	MESH:C568794	25253(Tax:10116)	Chemical	Gene	disposition|nmod|START_ENTITY disposition|dep|investigations investigations|nmod|deficient deficient|compound|END_ENTITY	Binding to dipeptidyl_peptidase-4 determines the disposition of linagliptin -LRB- BI_1356 -RRB- -- investigations in DPP-4 deficient and wildtype rats .
22217485	0	linagliptin	27,38	DPP-4	10,15	linagliptin	DPP-4	MESH:C568794	25253(Tax:10116)	Chemical	Gene	reduce|nsubj|START_ENTITY inhibitors|ccomp|reduce inhibitors|nsubj|END_ENTITY	The novel DPP-4 inhibitors linagliptin and BI_14361 reduce infarct size after myocardial_ischemia / reperfusion in rats .
22997980	0	linagliptin	32,43	DPP-4	15,20	linagliptin	DPP-4	MESH:C568794	25253(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Effects of the DPP-4 inhibitor , linagliptin , in diet-induced obese rats : a comparison in naive and exenatide-treated animals .
23319869	0	linagliptin	36,47	DPP-4	9,14	linagliptin	DPP-4	MESH:C568794	1803	Chemical	Gene	focus|nmod|START_ENTITY inhibitors|dep|focus inhibitors|compound|END_ENTITY	Emerging DPP-4 inhibitors : focus on linagliptin for type 2 diabetes .
23461781	8	linagliptin	1335,1346	DPP-4	1288,1293	linagliptin	SGLT2	MESH:C568794	6524	Chemical	Gene	reduced|dep|START_ENTITY reduced|nsubjpass|dose dose|nmod|inhibitors inhibitors|compound|END_ENTITY	The dose of DPP-4 inhibitors should be reduced -LRB- except for linagliptin -RRB- , whereas both the efficacy and safety of SGLT2 inhibitors are questionable in presence of CKD .
24393553	0	linagliptin	75,86	DPP-4	59,64	linagliptin	DPP-4	MESH:C568794	1803	Chemical	Gene	START_ENTITY|nsubj|analysis analysis|nmod|inhibitor inhibitor|compound|END_ENTITY	Population pharmacokinetic/pharmacodynamic analysis of the DPP-4 inhibitor linagliptin in Japanese patients with type_2_diabetes_mellitus .
24996141	0	linagliptin	79,90	DPP-4	27,32	linagliptin	DPP-4	MESH:C568794	1803	Chemical	Gene	based|nmod|START_ENTITY design|acl|based inhibitors|nmod|design inhibitors|nsubj|Discovery Discovery|nmod|END_ENTITY	Discovery of highly potent DPP-4 inhibitors by hybrid compound design based on linagliptin and alogliptin .
25986579	0	linagliptin	22,33	DPP-4	0,5	linagliptin	DPP-4	MESH:C568794	13482(Tax:10090)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	DPP-4 inhibition with linagliptin ameliorates cognitive impairment and brain atrophy induced by transient cerebral ischemia in type 2 diabetic mice .
26224765	0	linagliptin	39,50	Dipeptidyl_peptidase-4	0,22	linagliptin	Dipeptidyl peptidase-4	MESH:C568794	1803	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Dipeptidyl_peptidase-4 inhibition with linagliptin and effects on hyperglycaemia and albuminuria in patients with type_2_diabetes_and_renal_dysfunction : Rationale and design of the MARLINA-T2D trial .
26277250	0	linagliptin	34,45	Dipeptidyl_peptidase-4	0,22	linagliptin	Dipeptidyl peptidase-4	MESH:C568794	13482(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Dipeptidyl_peptidase-4 inhibitor , linagliptin , ameliorates endothelial_dysfunction and atherogenesis in normoglycemic apolipoprotein-E deficient mice .
19476474	0	linagliptin	78,89	dipeptidyl_peptidase-4	93,115	linagliptin	dipeptidyl peptidase-4	MESH:C568794	1803	Chemical	Gene	doses|nmod|START_ENTITY pharmacodynamics|nmod|doses Pharmacokinetics|appos|pharmacodynamics Pharmacokinetics|appos|inhibitor inhibitor|amod|END_ENTITY	Pharmacokinetics , pharmacodynamics and tolerability of multiple oral doses of linagliptin , a dipeptidyl_peptidase-4 inhibitor in male type 2 diabetes patients .
19771584	0	linagliptin	64,75	dipeptidyl_peptidase-4	11,33	linagliptin	dipeptidyl peptidase-4	MESH:C568794	25253(Tax:10116)	Chemical	Gene	disposition|nmod|START_ENTITY Binding|nsubj|disposition Binding|nmod|END_ENTITY	Binding to dipeptidyl_peptidase-4 determines the disposition of linagliptin -LRB- BI_1356 -RRB- -- investigations in DPP-4 deficient and wildtype rats .
20086031	0	linagliptin	77,88	dipeptidyl_peptidase-4	43,65	linagliptin	dipeptidyl peptidase-4	MESH:C568794	1803	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	The metabolism and disposition of the oral dipeptidyl_peptidase-4 inhibitor , linagliptin , in humans .
20875371	0	linagliptin	91,102	dipeptidyl_peptidase-4	58,80	linagliptin	dipeptidyl peptidase-4	MESH:C568794	1803	Chemical	Gene	START_ENTITY|nsubj|Evaluation Evaluation|nmod|interaction interaction|nmod|inhibitor inhibitor|amod|END_ENTITY	Evaluation of the pharmacokinetic interaction between the dipeptidyl_peptidase-4 inhibitor linagliptin and pioglitazone in healthy volunteers .
25941160	0	linagliptin	52,63	dipeptidyl_peptidase-4	19,41	linagliptin	dipeptidyl peptidase-4	MESH:C568794	1803	Chemical	Gene	START_ENTITY|nsubj|Combination Combination|nmod|inhibitor inhibitor|amod|END_ENTITY	Combination of the dipeptidyl_peptidase-4 inhibitor linagliptin with insulin-based regimens in type 2 diabetes and chronic_kidney_disease .
3290174	0	lincomycin	11,21	beta-lactamase	42,56	lincomycin	beta-lactamase	MESH:D008034	7872529(Tax:562)	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of lincomycin on synthesis of TEM beta-lactamase by Escherichia_coli .
6163230	0	lindane	55,62	C-6	75,78	lindane	C-6	MESH:D001556	24237(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Different levels of changes induced by the insecticide lindane in cultured C-6 glioma cells .
10426785	0	lindane	10,17	cyclooxygenase-2	39,55	lindane	cyclooxygenase-2	MESH:D001556	29527(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of lindane and phenobarbital on cyclooxygenase-2 expression and prostanoid synthesis by Kupffer cells .
9879810	0	lindane	10,17	delta-aminolaevulinate_synthase	36,67	lindane	delta-aminolaevulinate synthase	MESH:D001556	211	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of lindane and heptachlor on delta-aminolaevulinate_synthase and its regulation .
21910986	0	lindenenyl_acetate	29,47	heme_oxygenase-1	52,68	lindenenyl acetate	heme oxygenase-1	MESH:C543034	3162	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Anti-inflammatory effects of lindenenyl_acetate via heme_oxygenase-1 and AMPK in human periodontal ligament cells .
26068520	0	linderane	42,51	CYP2C9	32,38	linderane	CYP2C9	null	1559	Chemical	Gene	inactivation|nmod|START_ENTITY inactivation|nmod|END_ENTITY	Mechanism-based inactivation of CYP2C9 by linderane .
21471285	0	linifanib	53,62	Akt	102,105	linifanib	Akt	MESH:C513486	207	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|pathway pathway|amod|END_ENTITY	The multitargeted receptor tyrosine kinase inhibitor linifanib -LRB- ABT-869 -RRB- induces apoptosis through an Akt and glycogen_synthase_kinase_3b-dependent pathway .
18843019	0	linoleic_acid	81,94	5-lipoxygenase	0,14	linoleic acid	5-lipoxygenase	MESH:D019787	240	Chemical	Gene	START_ENTITY|nsubj|protein protein|amod|END_ENTITY	5-lipoxygenase and 5-lipoxygenase-activating protein gene polymorphisms , dietary linoleic_acid , and risk for breast_cancer .
20965713	0	linoleic_acid	77,90	AMPK	10,14	linoleic acid	AMPK	MESH:D019787	5563	Chemical	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	Activated AMPK and prostaglandins are involved in the response to conjugated linoleic_acid and are sufficient to cause lipid reductions in adipocytes .
6153705	4	linoleic_acid	259,272	CSF	292,295	linoleic acid	CSF	MESH:D019787	1437	Chemical	Gene	content|amod|START_ENTITY content|nmod|END_ENTITY	The linoleic_acid content of control CSF -LRB- 1.6 + / - 0.8 nMol/ml -RRB- is considerably lower than the corresponding serum value -LRB- 2.5 -- 4.1 muMol/ml -RRB- .
10729206	0	linoleic_acid	53,66	CYP2C9	18,24	linoleic acid	CYP2C9	MESH:D019787	1559	Chemical	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification of CYP2C9 as a human liver microsomal linoleic_acid epoxygenase .
9635497	0	linoleic_acid	93,106	DNA_polymerase_beta	110,129	linoleic acid	DNA polymerase beta	MESH:D019787	5423	Chemical	Gene	effect|nmod|START_ENTITY enhances|dobj|effect enhances|nmod|END_ENTITY	An ergosterol_peroxide , a natural product that selectively enhances the inhibitory effect of linoleic_acid on DNA_polymerase_beta .
2233691	0	linoleic_acid	35,48	Epidermal_growth_factor	0,23	linoleic acid	Epidermal growth factor	MESH:D019787	1950	Chemical	Gene	START_ENTITY|nsubj|stimulates stimulates|compound|END_ENTITY	Epidermal_growth_factor stimulates linoleic_acid metabolism in BALB/c 3T3 fibroblasts .
16127743	0	linoleic_acid	48,61	ErbB3	72,77	linoleic acid	ErbB3	MESH:D019787	2065	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|amod|END_ENTITY	Trans-10 , cis-12 , not cis-9 , trans-11 , conjugated linoleic_acid decreases ErbB3 expression in HT-29 human colon_cancer cells .
22661989	0	linoleic_acid	28,41	ICAM-1	59,65	linoleic acid	ICAM-1	MESH:D019787	3383	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effect of palmitic_acid and linoleic_acid on expression of ICAM-1 and VCAM-1 in human bone marrow endothelial cells -LRB- HBMECs -RRB- .
21161439	0	linoleic_acid	52,65	INS-1	22,27	linoleic acid	INS-1	MESH:D019787	24505(Tax:10116)	Chemical	Gene	cells|nmod|START_ENTITY cells|compound|END_ENTITY	Long-term exposure of INS-1 rat insulinoma cells to linoleic_acid and glucose in vitro affects cell viability and function through mitochondrial-mediated pathways .
14704295	0	linoleic_acid	11,24	LDL_receptor	37,49	linoleic acid	LDL receptor	MESH:D019787	3949	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	Conjugated linoleic_acid upregulates LDL_receptor gene expression in HepG2 cells .
16286461	0	linoleic_acid	11,24	NAG-1	64,69	linoleic acid	NAG-1	MESH:D019787	9518	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Conjugated linoleic_acid stimulates an anti-tumorigenic protein NAG-1 in an isomer specific manner .
23832628	0	linoleic_acid	25,38	PPAR	12,16	linoleic acid	PPAR	MESH:D019787	25747(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|agonist agonist|compound|END_ENTITY	The natural PPAR agonist linoleic_acid stimulated insulin release in the rat pancreas .
21767451	0	linoleic_acid	11,24	PPAR-a	91,97	linoleic acid	PPAR-a	MESH:D019787	19013(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Conjugated linoleic_acid induces hepatic expression of fibroblast_growth_factor_21 through PPAR-a .
16288226	0	linoleic_acid	24,37	PPAR-gamma	79,89	linoleic acid	PPAR-gamma	MESH:D019787	5468	Chemical	Gene	metabolism|nmod|START_ENTITY modulates|nsubj|metabolism modulates|dobj|suppression suppression|nmod|activity activity|amod|END_ENTITY	Oxidative metabolism of linoleic_acid modulates PPAR-beta/delta suppression of PPAR-gamma activity .
17190681	0	linoleic_acid	19,32	PPAR-gamma	49,59	linoleic acid	PPAR-gamma	MESH:D019787	5468	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Dietary conjugated linoleic_acid enhances spleen PPAR-gamma mRNA expression in broiler chicks .
19299109	0	linoleic_acid	11,24	PPAR-gamma	61,71	linoleic acid	PPAR-gamma	MESH:D019787	5468	Chemical	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Conjugated linoleic_acid isomers ' roles in the regulation of PPAR-gamma and NF-kappaB DNA binding and subsequent expression of antioxidant enzymes in human umbilical vein endothelial cells .
12949056	0	linoleic_acid	78,91	PPAR_gamma	116,126	linoleic acid	PPAR gamma	MESH:D019787	5468	Chemical	Gene	metabolites|nmod|START_ENTITY Activation|nmod|metabolites ligands|advcl|Activation ligands|nmod|END_ENTITY	Activation of PPAR_gamma in colon_tumor cell lines by oxidized metabolites of linoleic_acid , endogenous ligands for PPAR_gamma .
12949056	0	linoleic_acid	78,91	PPAR_gamma	14,24	linoleic acid	PPAR gamma	MESH:D019787	5468	Chemical	Gene	metabolites|nmod|START_ENTITY Activation|nmod|metabolites Activation|nmod|END_ENTITY	Activation of PPAR_gamma in colon_tumor cell lines by oxidized metabolites of linoleic_acid , endogenous ligands for PPAR_gamma .
15211799	0	linoleic_acid	22,35	PPAR_gamma	39,49	linoleic acid	PPAR gamma	MESH:D019787	25664(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	-LSB- Effect of conjugated linoleic_acid on PPAR_gamma gene expression and serum leptin in obese rat -RSB- .
17354222	0	linoleic_acid	108,121	PPAR_gamma	15,25	linoleic acid	PPAR gamma	MESH:D019787	5468	Chemical	Gene	START_ENTITY|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of PPAR_gamma and E-cadherin/beta-catenin pathway in the antiproliferative effect of conjugated linoleic_acid in MCF-7 cells .
18304850	0	linoleic_acid	19,32	PPAR_gamma	43,53	linoleic acid	PPAR gamma	MESH:D019787	25664(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Dietary conjugated linoleic_acid increases PPAR_gamma gene expression in adipose tissue of obese rat , and improves insulin resistance .
17691108	0	linoleic_acid	73,86	PPARalpha	0,9	linoleic acid	PPARalpha	MESH:D019787	5465	Chemical	Gene	effect|nmod|START_ENTITY involved|nmod|effect involved|nsubjpass|END_ENTITY	PPARalpha and PP2A are involved in the proapoptotic effect of conjugated linoleic_acid on human hepatoma cell line SK-HEP-1 .
10985906	0	linoleic_acid	87,100	PPARgamma	14,23	linoleic acid	PPARgamma	MESH:D019787	25664(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY portion|nmod|activity mediate|dobj|portion mediate|nsubj|Activation Activation|nmod|END_ENTITY	Activation of PPARgamma may mediate a portion of the anticancer activity of conjugated linoleic_acid .
12754280	0	linoleic_acid	26,39	PPARgamma	107,116	linoleic acid	PPARgamma	MESH:D019787	5468	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|advcl|acting acting|nmod|modulator modulator|compound|END_ENTITY	Trans10 , cis12-conjugated linoleic_acid prevents triacylglycerol accumulation in adipocytes by acting as a PPARgamma modulator .
16362414	0	linoleic_acid	36,49	PPARgamma	69,78	linoleic acid	PPARgamma	MESH:D019787	5468	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|activation activation|nmod|END_ENTITY	Peritoneal metastasis inhibition by linoleic_acid with activation of PPARgamma in human gastrointestinal_cancer cells .
17632092	0	linoleic_acid	39,52	PPARgamma	85,94	linoleic acid	PPARgamma	MESH:D019787	5468	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|involvement involvement|nmod|pathways pathways|compound|END_ENTITY	Antiproliferative effect of conjugated linoleic_acid in caco-2 cells : involvement of PPARgamma and APC/beta-catenin pathways .
18287349	0	linoleic_acid	28,41	PPARgamma	71,80	linoleic acid	PPARgamma	MESH:D019787	5468	Chemical	Gene	antagonizes|nsubj|START_ENTITY antagonizes|dobj|activity activity|compound|END_ENTITY	Trans-10 , cis-12 conjugated linoleic_acid antagonizes ligand-dependent PPARgamma activity in primary cultures of human adipocytes .
20089779	0	linoleic_acid	11,24	PPARgamma	106,115	linoleic acid	PPARgamma	MESH:D019787	19016(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Conjugated linoleic_acid ameliorates inflammation-induced colorectal_cancer in mice through activation of PPARgamma .
23077197	0	linoleic_acid	19,32	PPARy	43,48	linoleic acid	PPARy	MESH:D019787	5468	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Dietary conjugated linoleic_acid activates PPARy and the intestinal_trefoil_factor in SW480 cells and mice with dextran sulfate sodium-induced colitis .
25044948	0	linoleic_acid	29,42	PPARy	101,106	linoleic acid	PPARy	MESH:D019787	5468	Chemical	Gene	induced|amod|START_ENTITY reduces|iobj|induced reduces|dobj|expression expression|nmod|END_ENTITY	Docosahexaenoic_acid reduces linoleic_acid induced monocyte_chemoattractant_protein-1 expression via PPARy and nuclear factor-kB pathway in retinal pigment epithelial cells .
19116881	0	linoleic_acid	11,24	Spot_14	58,65	linoleic acid	Spot 14	MESH:D019787	7069	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Conjugated linoleic_acid -LRB- CLA -RRB- inhibits expression of the Spot_14 -LRB- THRSP -RRB- and fatty_acid_synthase genes and impairs the growth of human breast_cancer and liposarcoma cells .
16530768	0	linoleic_acid	31,44	apolipoprotein_E	94,110	linoleic acid	apolipoprotein E	MESH:D019787	11816(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Selective effect of conjugated linoleic_acid isomers on atherosclerotic_lesion development in apolipoprotein_E knockout mice .
3612314	0	linoleic_acid	22,35	cytochrome_P-450	55,71	linoleic acid	cytochrome P-450	MESH:D019787	25251(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|contents contents|nmod|END_ENTITY	Effect of autoxidized linoleic_acid on the contents of cytochrome_P-450 and cytochrome_b5 , and drug-metabolizing enzyme activities in rat liver .
5133008	0	linoleic_acid	14,27	cytochrome_P-450	75,91	linoleic acid	cytochrome P-450	MESH:D019787	25251(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of linoleic_acid , peroxidation and antioxidants on induction of cytochrome_P-450 in rat liver .
21767451	0	linoleic_acid	11,24	fibroblast_growth_factor_21	55,82	linoleic acid	fibroblast growth factor 21	MESH:D019787	56636(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Conjugated linoleic_acid induces hepatic expression of fibroblast_growth_factor_21 through PPAR-a .
20136431	0	linoleic_acid	27,40	insulin-like_growth_factor-I_receptor	50,87	linoleic acid	insulin-like growth factor-I receptor	MESH:D019787	25718(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	trans-10 , cis-12 conjugated linoleic_acid inhibits insulin-like_growth_factor-I_receptor signaling in TSU-Pr1 human bladder_cancer cells .
21795062	0	linoleic_acid	28,41	interleukin-10	185,199	linoleic acid	interleukin-10	MESH:D019787	3586	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|nmod|induction induction|nmod|END_ENTITY	Trans-10 , cis-12-conjugated linoleic_acid attenuates tumor_necrosis_factor-a production by lipopolysaccharide-stimulated porcine peripheral blood mononuclear cells through induction of interleukin-10 .
16621025	0	linoleic_acid	112,125	interleukin-8	13,26	linoleic acid	interleukin-8	MESH:D019787	3576	Chemical	Gene	START_ENTITY|nsubj|Induction Induction|nmod|expression expression|amod|END_ENTITY	Induction of interleukin-8 expression in porcine peripheral blood mononuclear cells by trans10-cis12 conjugated linoleic_acid .
11091103	0	linoleic_acid	60,73	leptin	25,31	linoleic acid	leptin	MESH:D019787	25608(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|reduction reduction|nmod|level level|compound|END_ENTITY	Acute reduction of serum leptin level by dietary conjugated linoleic_acid in Sprague-Dawley_rats .
15868135	0	linoleic_acid	50,63	leptin	97,103	linoleic acid	leptin	MESH:D019787	16846(Tax:10090)	Chemical	Gene	triggered|nmod|START_ENTITY Hyperinsulinaemia|acl|triggered associated|nsubjpass|Hyperinsulinaemia associated|nmod|decrease decrease|nmod|levels levels|compound|END_ENTITY	Hyperinsulinaemia triggered by dietary conjugated linoleic_acid is associated with a decrease in leptin and adiponectin plasma levels and pancreatic_beta_cell_hyperplasia in the mouse .
21186986	0	linoleic_acid	40,53	leptin	14,20	linoleic acid	leptin	MESH:D019787	16846(Tax:10090)	Chemical	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	Modulation of leptin levels by oxidized linoleic_acid : a connection to atherosclerosis ?
11257467	0	linoleic_acid	32,45	lipoprotein_lipase	57,75	linoleic acid	lipoprotein lipase	MESH:D019787	16956(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Different effects of conjugated linoleic_acid isomers on lipoprotein_lipase activity in 3T3-L1 adipocytes .
19339774	0	linoleic_acid	19,32	lipoprotein_lipase	57,75	linoleic acid	lipoprotein lipase	MESH:D019787	16956(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|modulation modulation|amod|END_ENTITY	Dietary conjugated linoleic_acid induces tissue-specific lipoprotein_lipase mRNA modulation in high-sucrose-fed mice .
8033289	0	linoleic_acid	76,89	lipoxygenase-1	42,56	linoleic acid	lipoxygenase-1	MESH:D019787	547923(Tax:3847)	Chemical	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	Oxidation of furan_fatty_acids by soybean lipoxygenase-1 in the presence of linoleic_acid .
11949867	0	linoleic_acid	64,77	milk	95,99	linoleic acid	milk	MESH:D019787	100532204	Chemical	Gene	content|amod|START_ENTITY content|nmod|END_ENTITY	Feeding fish meal and extruded soybeans enhances the conjugated linoleic_acid -LRB- CLA -RRB- content of milk .
14594243	0	linoleic_acid	101,114	milk	17,21	linoleic acid	milk	MESH:D019787	100532204	Chemical	Gene	START_ENTITY|nsubj|response response|nmod|END_ENTITY	Dose response of milk fat to intravenous administration of the trans-10 , cis-12 isomer of conjugated linoleic_acid .
9566998	0	linoleic_acid	45,58	milk	77,81	linoleic acid	milk	MESH:D019787	100532204	Chemical	Gene	concentrations|amod|START_ENTITY concentrations|nmod|END_ENTITY	Dietary fatty_acid sources affect conjugated linoleic_acid concentrations in milk from lactating dairy cows .
18568373	0	linoleic_acid	88,101	p38	106,109	linoleic acid	p38	MESH:D019787	81649(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|pathway pathway|amod|END_ENTITY	Oleic_acid prevents apoptotic cell death induced by trans10 , cis12 isomer of conjugated linoleic_acid via p38 MAP kinase dependent pathway .
15159255	0	linoleic_acid	11,24	parathyroid_hormone	33,52	linoleic acid	parathyroid hormone	MESH:D019787	24694(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	Conjugated linoleic_acid reduces parathyroid_hormone in health and in polycystic_kidney_disease in rats .
18430558	0	linoleic_acid	19,32	parathyroid_hormone	72,91	linoleic acid	parathyroid hormone	MESH:D019787	24694(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	Dietary conjugated linoleic_acid in the cis-9 , trans-11 isoform reduces parathyroid_hormone in male , but not female , rats .
9450644	0	linoleic_acid	31,44	phosvitin	73,82	linoleic acid	phosvitin	MESH:D019787	1460	Chemical	Gene	oxidation|amod|START_ENTITY oxidation|nmod|END_ENTITY	Inhibition of Fe -LRB- II -RRB- catalyzed linoleic_acid oxidation and DNA damage by phosvitin .
17179821	0	linoleic_acid	66,79	plasminogen_activator_inhibitor-1	18,51	linoleic acid	plasminogen activator inhibitor-1	MESH:D019787	5054	Chemical	Gene	alteration|nmod|START_ENTITY alteration|nmod|expression expression|amod|END_ENTITY	The alteration of plasminogen_activator_inhibitor-1 expression by linoleic_acid and fenofibrate in HepG2 cells .
22313584	0	linoleic_acid	21,34	prolyl_hydroxylase_1	52,72	linoleic acid	prolyl hydroxylase 1	MESH:D019787	112406(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Effect of conjugated linoleic_acid on inhibition of prolyl_hydroxylase_1 in hearts of mice .
3052059	0	linoleic_acid	30,43	renin	14,19	linoleic acid	renin	MESH:D019787	5972	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of renin by plasma linoleic_acid .
23155420	0	linoleic_acid	61,74	sirtuin_1	20,29	linoleic acid	sirtuin 1	MESH:D019787	23411	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Cross regulation of sirtuin_1 , AMPK , and PPARy in conjugated linoleic_acid treated adipocytes .
22234647	0	linoleic_acid	61,74	stearoyl-Coenzyme_A_desaturase_1	78,110	linoleic acid	stearoyl-Coenzyme A desaturase 1	MESH:D019787	20249(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Transcriptional analysis reveals a high impact of conjugated linoleic_acid on stearoyl-Coenzyme_A_desaturase_1 mRNA expression in mice gastrocnemius muscle .
15469957	0	linoleic_acid	9,22	syndecan-4	60,70	linoleic acid	syndecan-4	MESH:D019787	6385	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Oxidized linoleic_acid regulates expression and shedding of syndecan-4 .
12524473	0	linoleic_acid	19,32	tumor_necrosis_factor-alpha	64,91	linoleic acid	tumor necrosis factor-alpha	MESH:D019787	21926(Tax:10090)	Chemical	Gene	decreased|nsubj|START_ENTITY decreased|dobj|production production|amod|END_ENTITY	Dietary conjugated linoleic_acid decreased cachexia , macrophage tumor_necrosis_factor-alpha production , and modifies splenocyte cytokines production .
17002473	0	linoleic_acid	19,32	tumor_necrosis_factor-alpha	41,68	linoleic acid	tumor necrosis factor-alpha	MESH:D019787	24835(Tax:10116)	Chemical	Gene	lowered|nsubj|START_ENTITY lowered|dobj|content content|amod|END_ENTITY	Dietary conjugated linoleic_acid lowered tumor_necrosis_factor-alpha content and altered expression of genes related to lipid metabolism and insulin sensitivity in the skeletal muscle of Zucker rats .
17540578	0	linoleic_acid	83,96	tumor_necrosis_factor-alpha	16,43	linoleic acid	tumor necrosis factor-alpha	MESH:D019787	21926(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Upregulation of tumor_necrosis_factor-alpha expression by trans10-cis12 conjugated linoleic_acid enhances phagocytosis of RAW macrophages via a peroxisome_proliferator-activated_receptor_gamma-dependent pathway .
7207459	0	linoleic_acid_hydroperoxide	7,34	cytochrome_P-450	94,110	linoleic acid hydroperoxide	cytochrome P-450	MESH:C008285	4051	Chemical	Gene	Use|nmod|START_ENTITY Use|nmod|END_ENTITY	Use of linoleic_acid_hydroperoxide in the determination of absolute spectra of membrane-bound cytochrome_P-450 .
21044882	0	linoleic_acid_hydroperoxide	21,48	paraoxonase_1	58,71	linoleic acid hydroperoxide	paraoxonase 1	MESH:C008285	5444	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Human carotid lesion linoleic_acid_hydroperoxide inhibits paraoxonase_1 -LRB- PON1 -RRB- activity via reaction with PON1 free sulfhydryl_cysteine 284 .
10404015	0	linoleic_acids	19,33	IGF-I	46,51	linoleic acids	IGF-I	MESH:D008041	24482(Tax:10116)	Chemical	Gene	alter|nsubj|START_ENTITY alter|dobj|END_ENTITY	Dietary conjugated linoleic_acids alter serum IGF-I and IGF binding protein concentrations and reduce bone formation in rats fed -LRB- n-6 -RRB- or -LRB- n-3 -RRB- fatty_acids .
2985102	0	linoleic_and_gammalinolenic_acids	43,76	angiotensin_II	104,118	linoleic and gammalinolenic acids	angiotensin II	null	183	Chemical	Gene	START_ENTITY|nmod|response response|nmod|END_ENTITY	The effect of dietary supplementation with linoleic_and_gammalinolenic_acids on the pressor response to angiotensin_II -- a possible role in pregnancy-induced hypertension ?
9299418	0	linolenic_acid	6,20	maspin	45,51	linolenic acid	maspin	MESH:D017962	5268	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Gamma linolenic_acid regulates expression of maspin and the motility of cancer cells .
8827087	0	linomide	25,33	tumor_necrosis_factor-alpha	43,70	linomide	tumor necrosis factor-alpha	MESH:C045282	21926(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|amod|END_ENTITY	The antiangiogenic agent linomide inhibits tumor_necrosis_factor-alpha secretion via inhibition of its synthesis .
11378256	0	linopirdine	35,46	Fos	55,58	linopirdine	Fos	MESH:C061017	314322(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	The acetylcholine release enhancer linopirdine induces Fos in neocortex of aged rats .
8294165	0	linsidomine	20,31	SIN_1	33,38	linsidomine	SIN 1	MESH:C002385	79109	Chemical	Gene	Pharmacokinetics|nmod|START_ENTITY Pharmacokinetics|appos|END_ENTITY	Pharmacokinetics of linsidomine -LRB- SIN_1 -RRB- after single and multiple intravenous short infusions in patients with renal_insufficiency .
7941195	0	linsidomine_chlorhydrate	31,55	SIN-1	57,62	linsidomine chlorhydrate	SIN-1	null	79109	Chemical	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of the nitric_oxide donor linsidomine_chlorhydrate -LRB- SIN-1 -RRB- in the diagnosis and treatment of erectile_dysfunction .
25335932	0	linsitinib	20,30	IGF-1R	62,68	linsitinib	IGF-1R	null	3480	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	A phase Ib study of linsitinib -LRB- OSI-906 -RRB- , a dual inhibitor of IGF-1R and IR tyrosine kinase , in combination with everolimus as treatment for patients with refractory metastatic colorectal_cancer .
12821717	0	lipid_A	45,52	Cot/Tpl2	0,8	lipid A	Cot/Tpl2	MESH:D008050	26410(Tax:10090)	Chemical	Gene	essential|nmod|START_ENTITY essential|nsubj|END_ENTITY	Cot/Tpl2 is essential for RANKL induction by lipid_A in osteoblasts .
11521054	0	lipid_A	86,93	TNF-alpha	13,22	lipid A	TNF-alpha	MESH:D008050	7124	Chemical	Gene	analog|compound|START_ENTITY E5531|appos|analog effect|nmod|E5531 Induction|dep|effect Induction|nmod|END_ENTITY	Induction of TNF-alpha and MnSOD by endotoxin : effect of E5531 , a synthetic non-toxic lipid_A analog .
21782253	0	lipid_A	59,66	TNF-alpha	70,79	lipid A	TNF-alpha	MESH:D008050	7124	Chemical	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	The antagonist activity of lipid IVa on the stimulation by lipid_A of TNF-alpha production from canine blood mononuclear cells .
7525728	0	lipid_A	20,27	TNF-alpha	39,48	lipid A	TNF-alpha	MESH:D008050	7124	Chemical	Gene	analogue|nmod|START_ENTITY stimulates|nsubj|analogue stimulates|dobj|release release|amod|END_ENTITY	Acyclic analogue of lipid_A stimulates TNF-alpha and arachidonate release via a unique LPS-signaling pathway .
1536865	0	lipid_A	39,46	melittin	15,23	lipid A	melittin	MESH:D008050	406130(Tax:7460)	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of melittin with endotoxic lipid_A .
11862417	0	lipid_A	63,70	tumor_necrosis_factor	26,47	lipid A	tumor necrosis factor	MESH:D008050	21926(Tax:10090)	Chemical	Gene	analog|compound|START_ENTITY END_ENTITY|nmod|analog	Induction of intratumoral tumor_necrosis_factor by a synthetic lipid_A analog , ONO-4007 , with less tolerance in repeated administration and its implication in potent antitumor effects with low toxicity .
1547025	0	lipid_A	140,147	tumor_necrosis_factor	55,76	lipid A	tumor necrosis factor	MESH:D008050	7124	Chemical	Gene	Ia|nmod|START_ENTITY END_ENTITY|nmod|Ia	Modulation of lipopolysaccharide-induced production of tumor_necrosis_factor , interleukin_1 , and interleukin_6 by synthetic precursor Ia of lipid_A .
1576244	0	lipid_A	89,96	tumor_necrosis_factor	43,64	lipid A	tumor necrosis factor	MESH:D008050	7124	Chemical	Gene	structures|amod|START_ENTITY Inhibition|nmod|structures Inhibition|nmod|production production|compound|END_ENTITY	Inhibition of endotoxin or lipid_A-induced tumor_necrosis_factor production by synthetic lipid_A partial structures in human peripheral blood mononuclear cells .
2497979	0	lipid_A	112,119	tumor_necrosis_factor	27,48	lipid A	tumor necrosis factor	MESH:D008050	21926(Tax:10090)	Chemical	Gene	analog|compound|START_ENTITY combined|nmod|analog combined|nsubj|Induction Induction|nmod|END_ENTITY	Induction of an endogenous tumor_necrosis_factor in mice by murine recombinant interferon-gamma combined with a lipid_A subunit analog -LRB- GLA-60 -RRB- of low toxicity .
6528335	0	lipid_A	8,15	tumor_necrosis_factor	105,126	lipid A	tumor necrosis factor	MESH:D008050	7124	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|activity activity|nmod|END_ENTITY	Role of lipid_A in the production of tumor_necrosis_factor and differences in antitumor activity between tumor_necrosis_factor and lipopolysaccharide .
6528335	0	lipid_A	8,15	tumor_necrosis_factor	37,58	lipid A	tumor necrosis factor	MESH:D008050	7124	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|production production|nmod|END_ENTITY	Role of lipid_A in the production of tumor_necrosis_factor and differences in antitumor activity between tumor_necrosis_factor and lipopolysaccharide .
7542128	0	lipid_A	145,152	tumor_necrosis_factor	27,48	lipid A	tumor necrosis factor	MESH:D008050	21926(Tax:10090)	Chemical	Gene	analog|compound|START_ENTITY DT-5461|appos|analog effects|nmod|DT-5461 augmented|nmod|effects augmented|nsubj|production production|nmod|END_ENTITY	Intratumoral production of tumor_necrosis_factor augmented by endogenous interferons results in potent antitumor effects of DT-5461 , a synthetic lipid_A analog .
8830332	0	lipid_A	27,34	tumor_necrosis_factor	49,70	lipid A	tumor necrosis factor	MESH:D008050	7124	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of a new synthetic lipid_A on endogenous tumor_necrosis_factor production and antitumor activity against human pancreatic_cancer cells .
9023454	0	lipid_A	10,17	tumor_necrosis_factor	106,127	lipid A	tumor necrosis factor	MESH:D008050	7124	Chemical	Gene	produces|nsubj|START_ENTITY produces|nmod|production production|nmod|END_ENTITY	Synthetic lipid_A produces antitumor effect in a hamster pancreatic_carcinoma model through production of tumor_necrosis_factor from activated macrophages .
9101415	0	lipid_A	101,108	tumor_necrosis_factor	13,34	lipid A	tumor necrosis factor	MESH:D008050	21926(Tax:10090)	Chemical	Gene	analogue|compound|START_ENTITY Induction|nmod|analogue Induction|nmod|END_ENTITY	Induction of tumor_necrosis_factor in a murine tumor by systemic administration of a novel synthetic lipid_A analogue , ONO-4007 .
9891479	0	lipid_A	102,109	tumor_necrosis_factor	13,34	lipid A	tumor necrosis factor	MESH:D008050	103694380	Chemical	Gene	analog|compound|START_ENTITY ONO-4007|appos|analog END_ENTITY|nmod|ONO-4007	Intratumoral tumor_necrosis_factor induction and tumor growth suppression by ONO-4007 , a low-toxicity lipid_A analog .
4000132	0	lipid_A	8,15	tumour_necrosis_factor	50,72	lipid A	tumour necrosis factor	MESH:D008050	21926(Tax:10090)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|production production|nmod|END_ENTITY	Role of lipid_A of endotoxin in the production of tumour_necrosis_factor .
3058861	0	lipoamide	50,59	LPD1	31,35	lipoamide	LPD1	MESH:C013091	850527(Tax:4932)	Chemical	Gene	dehydrogenase|compound|START_ENTITY dehydrogenase|compound|END_ENTITY	The nucleotide sequence of the LPD1 gene encoding lipoamide dehydrogenase in Saccharomyces_cerevisiae : comparison between eukaryotic and prokaryotic sequences for related enzymes and identification of potential upstream control sites .
15190785	0	lipofectamin	44,56	endostatin	23,33	lipofectamin	endostatin	null	80781	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	-LSB- Transfection of human endostatin gene with lipofectamin and the expression of hES protein in Tca8113 cell -RSB- .
23892131	0	lipoic_acid	29,40	GSK-3b	63,69	lipoic acid	GSK-3b	MESH:D008063	2932	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Anti-inflammatory effects of lipoic_acid through inhibition of GSK-3b in lipopolysaccharide-induced BV-2 microglial cells .
14985508	0	lipoic_acid	119,130	Nrf2	39,43	lipoic acid	Nrf2	MESH:D008063	83619(Tax:10116)	Chemical	Gene	reversible|advcl|START_ENTITY synthesis|acl:relcl|reversible loss|nmod|synthesis causes|dobj|loss causes|nsubj|Decline Decline|nmod|activity activity|nmod|END_ENTITY	Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis , which is reversible with lipoic_acid .
25841776	0	lipoic_acid	51,62	Nrf2	18,22	lipoic acid	Nrf2	MESH:D008063	83619(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nmod|effect	Essential role of Nrf2 in the protective effect of lipoic_acid against lipoapoptosis in hepatocytes .
25449271	0	lipoic_acid	6,17	fibroblast_growth_factor_21	34,61	lipoic acid	fibroblast growth factor 21	MESH:D008063	56636(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Alpha lipoic_acid induces hepatic fibroblast_growth_factor_21 expression via up-regulation of CREBH .
22857892	0	lipooligosaccharide	15,34	SC096	76,81	lipooligosaccharide	SC096	CHEBI:35371	3283329(Tax:321314)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Involvement of lipooligosaccharide heptose residues of Haemophilus_parasuis SC096 strain in serum resistance , adhesion and invasion .
16139367	0	lipotechoic_acid	22,38	serum_amyloid_A3	81,97	lipotechoic acid	serum amyloid A3	null	281474(Tax:9913)	Chemical	Gene	START_ENTITY|dobj|expression expression|nmod|END_ENTITY	Staphylococcus_aureus lipotechoic_acid induces differential expression of bovine serum_amyloid_A3 -LRB- SAA3 -RRB- by mammary epithelial cells : Implications for early diagnosis of mastitis .
22542695	0	lipoteichoic_acid	10,27	IL-2	31,35	lipoteichoic acid	IL-2	MESH:C009900	3558	Chemical	Gene	START_ENTITY|nmod|release release|amod|END_ENTITY	Effect of lipoteichoic_acid on IL-2 and IL-5 release from T lymphocytes in asthma and COPD .
21092323	0	lipoteichoic_acid	131,148	MMP-9	85,90	lipoteichoic acid	MMP-9	MESH:C009900	4318	Chemical	Gene	induced|nmod|START_ENTITY expression|acl|induced expression|compound|END_ENTITY	Calmodulin kinase II-dependent transactivation of PDGF receptors mediates astrocytic MMP-9 expression and cell motility induced by lipoteichoic_acid .
16879708	0	lipoteichoic_acid	16,33	Toll-like_receptor_2	114,134	lipoteichoic acid	Toll-like receptor 2	MESH:C009900	310553(Tax:10116)	Chemical	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Highly purified lipoteichoic_acid induced pro-inflammatory signalling in primary culture of rat microglia through Toll-like_receptor_2 : selective potentiation of nitric_oxide production by muramyl_dipeptide .
19250704	0	lipoteichoic_acid	35,52	Toll-like_receptor_2	0,20	lipoteichoic acid	Toll-like receptor 2	MESH:C009900	7097	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Toll-like_receptor_2 activation by lipoteichoic_acid induces differential production of pro-inflammatory cytokines in human odontoblasts , dental pulp fibroblasts and immature dendritic cells .
24211871	0	lipoteichoic_acid	45,62	cyclooxygenase-2	76,92	lipoteichoic acid	cyclooxygenase-2	MESH:C009900	19225(Tax:10090)	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|expression expression|amod|END_ENTITY	Muramyl_dipeptide potentiates staphylococcal lipoteichoic_acid induction of cyclooxygenase-2 expression in macrophages .
24500697	0	lipoteichoic_acid	46,63	interleukin-6	94,107	lipoteichoic acid	interleukin-6	MESH:C009900	3569	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|production production|amod|END_ENTITY	Differential effects of low and high doses of lipoteichoic_acid on lipopolysaccharide-induced interleukin-6 production .
20735236	0	lipoyl_vildagliptin	20,39	dipeptidyl_peptidase_IV	49,72	lipoyl vildagliptin	dipeptidyl peptidase IV	MESH:C554665	25253(Tax:10116)	Chemical	Gene	Pharmacokinetics|nmod|START_ENTITY END_ENTITY|nsubj|Pharmacokinetics	Pharmacokinetics of lipoyl_vildagliptin , a novel dipeptidyl_peptidase_IV inhibitor after oral administration in rats .
26646674	0	liquiritigenin	19,33	AMPK	0,4	liquiritigenin	AMPK	MESH:C083152	5563	Chemical	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	AMPK activation by liquiritigenin inhibited oxidative hepatic injury and mitochondrial_dysfunction induced by nutrition deprivation as mediated with induction of farnesoid_X_receptor .
18332856	0	liquiritigenin	29,43	iNOS	102,106	liquiritigenin	iNOS	MESH:C083152	18126(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nsubj|effects	Anti-inflammatory effects of liquiritigenin as a consequence of the inhibition of NF-kappaB-dependent iNOS and proinflammatory cytokines production .
26977279	0	liraglutide	19,30	GLP-1	4,9	liraglutide	GLP-1	MESH:C439759	100125288	Chemical	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	The GLP-1 agonist , liraglutide , as a pharmacotherapy for obesity .
23657563	0	liraglutide	41,52	endothelin-1	62,74	liraglutide	endothelin-1	MESH:C439759	1906	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Glucagon-like_peptide-1 receptor agonist liraglutide inhibits endothelin-1 in endothelial cell by repressing nuclear factor-kappa B activation .
10916115	0	lisinopril	46,56	ACE	94,97	lisinopril	ACE	MESH:D017706	1636	Chemical	Gene	left_ventricular_hypertrophy|nmod|START_ENTITY Regression|nmod|left_ventricular_hypertrophy Regression|dep|role role|nmod|polymorphism polymorphism|compound|END_ENTITY	Regression of left_ventricular_hypertrophy by lisinopril after renal_transplantation : role of ACE gene polymorphism .
11450501	0	lisinopril	35,45	ACE	21,24	lisinopril	ACE	MESH:D017706	24310(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|influence influence|nmod|inhibitor inhibitor|compound|END_ENTITY	The influence of the ACE inhibitor lisinopril on the glomerular metabolism of proteolytic enzymes in diabetic rats .
12138046	2	lisinopril	109,119	ACE	155,158	lisinopril	ACE	MESH:D017706	1636	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|appos|END_ENTITY	My physician initially prescribed lisinopril , an angiotensin-converting_enzyme -LRB- ACE -RRB- inhibitor .
1660796	0	lisinopril	35,45	ACE	21,24	lisinopril	ACE	MESH:D017706	100715217	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|inhibitor inhibitor|compound|END_ENTITY	Acute effects of the ACE inhibitor lisinopril on cardiac electrophysiological parameters of isolated guinea_pig hearts .
23178416	0	lisinopril	72,82	ACE	17,20	lisinopril	ACE	MESH:D017706	1636	Chemical	Gene	inhibitor-induced|nmod|START_ENTITY inhibitor-induced|nsubj|END_ENTITY	Life-threatening ACE inhibitor-induced angioedema after eleven years on lisinopril .
23455217	0	lisinopril	70,80	ACE	85,88	lisinopril	ACE	MESH:D017706	1636	Chemical	Gene	use|nmod|START_ENTITY response|nmod|use alteration|nmod|response Study|nmod|alteration Study|dep|inhibitor inhibitor|compound|END_ENTITY	Study of alteration of adrenergic receptor response by chronic use of lisinopril : an ACE inhibitor .
2550696	0	lisinopril	76,86	ACE	58,61	lisinopril	ACE	MESH:D017706	1636	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|Efficacy Efficacy|nmod|effect effect|nmod|END_ENTITY	Efficacy and variability of the antiproteinuric effect of ACE inhibition by lisinopril .
3033998	0	lisinopril	41,51	ACE	90,93	lisinopril	ACE	MESH:D017706	1636	Chemical	Gene	effects|nmod|START_ENTITY inhibitor|nsubj|effects inhibitor|nsubj|angiotensin_converting_enzyme angiotensin_converting_enzyme|appos|END_ENTITY	Antihypertensive and hormonal effects of lisinopril , a new angiotensin_converting_enzyme -LRB- ACE -RRB- inhibitor in patients with renovascular_hypertension .
7600744	0	lisinopril	23,33	ACE	3,6	lisinopril	ACE	MESH:D017706	1636	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Is ACE inhibition with lisinopril helpful in diabetic_neuropathy ?
11151038	0	lisinopril	44,54	Angiotensin-converting_enzyme	0,29	lisinopril	Angiotensin-converting enzyme	MESH:D017706	24310(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Angiotensin-converting_enzyme inhibition by lisinopril enhances liver_regeneration in rats .
23660814	0	lisinopril	108,118	Angiotensin_converting_enzyme	63,92	lisinopril	Angiotensin converting enzyme	MESH:D017706	1636	Chemical	Gene	dynamics|nmod|START_ENTITY dynamics|dobj|studies studies|nmod|END_ENTITY	Molecular dynamics simulation and molecular docking studies of Angiotensin_converting_enzyme with inhibitor lisinopril and amyloid Beta Peptide .
10587334	0	lisinopril	90,100	angiotensin-converting_enzyme	49,78	lisinopril	angiotensin-converting enzyme	MESH:D017706	1636	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Comparative effects of low and high doses of the angiotensin-converting_enzyme inhibitor , lisinopril , on morbidity and mortality in chronic heart_failure .
11872207	0	lisinopril	80,90	angiotensin-converting_enzyme	40,69	lisinopril	angiotensin-converting enzyme	MESH:D017706	1636	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|therapy therapy|nmod|inhibitor inhibitor|amod|END_ENTITY	Effect of hypertension therapy with the angiotensin-converting_enzyme inhibitor lisinopril on hyperandrogenism in women with polycystic_ovary_syndrome .
12138046	2	lisinopril	109,119	angiotensin-converting_enzyme	124,153	lisinopril	angiotensin-converting enzyme	MESH:D017706	1636	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	My physician initially prescribed lisinopril , an angiotensin-converting_enzyme -LRB- ACE -RRB- inhibitor .
1329477	0	lisinopril	65,75	angiotensin-converting_enzyme	12,41	lisinopril	angiotensin-converting enzyme	MESH:D017706	1636	Chemical	Gene	inhibition|dep|START_ENTITY inhibition|amod|END_ENTITY	Long-acting angiotensin-converting_enzyme inhibition : once-daily lisinopril versus twice-daily captopril in mild-to-moderate heart_failure .
15752941	0	lisinopril	102,112	angiotensin-converting_enzyme	20,49	lisinopril	angiotensin-converting enzyme	MESH:D017706	24310(Tax:10116)	Chemical	Gene	trandolapril|nmod|START_ENTITY administration|nmod|trandolapril END_ENTITY|nmod|administration	Inhibition of brain angiotensin-converting_enzyme by peripheral administration of trandolapril versus lisinopril in Wistar_rats .
18483087	0	lisinopril	52,62	angiotensin-converting_enzyme	96,125	lisinopril	angiotensin-converting enzyme	MESH:D017706	1636	Chemical	Gene	complexes|amod|START_ENTITY +|dobj|complexes +|nmod|imaging imaging|nmod|expression expression|amod|END_ENTITY	Synthesis and evaluation of a series of 99mTc -LRB- CO -RRB- 3 + lisinopril complexes for in vivo imaging of angiotensin-converting_enzyme expression .
20233165	0	lisinopril	116,126	angiotensin-converting_enzyme	58,87	lisinopril	angiotensin-converting enzyme	MESH:D017706	1636	Chemical	Gene	derivative|nmod|START_ENTITY using|dobj|derivative using|advmod|END_ENTITY	Characterization of domain-selective inhibitor binding in angiotensin-converting_enzyme using a novel derivative of lisinopril .
2844082	0	lisinopril	84,94	angiotensin-converting_enzyme	38,67	lisinopril	angiotensin-converting enzyme	MESH:D017706	1636	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Clinical experience and rationale for angiotensin-converting_enzyme inhibition with lisinopril as the initial treatment for hypertension in older patients .
2844082	7	lisinopril	932,942	angiotensin-converting_enzyme	977,1006	lisinopril	angiotensin-converting enzyme	MESH:D017706	1636	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	However , recent studies with lisinopril , a new long-acting , nonsulfhydryl angiotensin-converting_enzyme inhibitor , indicate that reductions_in_systolic_and_diastolic_blood_pressure in older hypertensive patients receiving either angiotensin-converting_enzyme inhibitor or hydrochlorothiazide monotherapy were not significantly different .
7602241	0	lisinopril	86,96	angiotensin-converting_enzyme	14,43	lisinopril	angiotensin-converting enzyme	MESH:D017706	24310(Tax:10116)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of angiotensin-converting_enzyme and attenuation of myocardial_fibrosis by lisinopril in rats receiving angiotensin_II .
9506845	0	lisinopril	25,35	angiotensin_I-converting_enzyme	47,78	lisinopril	angiotensin I-converting enzyme	MESH:D017706	1636	Chemical	Gene	analysis|nmod|START_ENTITY analysis|amod|END_ENTITY	Calorimetric analysis of lisinopril binding to angiotensin_I-converting_enzyme .
10344043	0	lisinopril	40,50	angiotensin_II	85,99	lisinopril	angiotensin II	MESH:D017706	183	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	The incidence of cough : a comparison of lisinopril , placebo and telmisartan , a novel angiotensin_II antagonist .
1326422	0	lisinopril	67,77	angiotensin_II	12,26	lisinopril	angiotensin II	MESH:D017706	183	Chemical	Gene	administration|nmod|START_ENTITY Circulating|nmod|administration Circulating|dobj|levels levels|amod|END_ENTITY	Circulating angiotensin_II levels under repeated administration of lisinopril in normal subjects .
1963909	0	lisinopril	16,26	angiotensin_II	63,77	lisinopril	angiotensin II	MESH:D017706	183	Chemical	Gene	comparison|nmod|START_ENTITY comparison|nmod|levels levels|amod|enalapril enalapril|nmod|END_ENTITY	A comparison of lisinopril with enalapril by monitoring plasma angiotensin_II levels in humans .
7602241	0	lisinopril	86,96	angiotensin_II	115,129	lisinopril	angiotensin II	MESH:D017706	24179(Tax:10116)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|rats rats|acl|receiving receiving|dobj|END_ENTITY	Inhibition of angiotensin-converting_enzyme and attenuation of myocardial_fibrosis by lisinopril in rats receiving angiotensin_II .
7796449	0	lisinopril	86,96	angiotensin_II	14,28	lisinopril	angiotensin II	MESH:D017706	24179(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Prevention Prevention|nmod|END_ENTITY	Prevention of angiotensin_II induced myocyte_necrosis and coronary_vascular_damage by lisinopril and losartan in the rat .
9322828	0	lisinopril	178,188	angiotensin_II	17,31	lisinopril	angiotensin II	MESH:D017706	183	Chemical	Gene	START_ENTITY|nsubj|Valsartan Valsartan|appos|antagonist antagonist|compound|END_ENTITY	Valsartan , a new angiotensin_II antagonist for the treatment of essential hypertension : efficacy , tolerability and safety compared to an angiotensin-converting enzyme inhibitor , lisinopril .
11079227	0	lisinopril	51,61	angiotensin_converting_enzyme	11,40	lisinopril	angiotensin converting enzyme	MESH:D017706	1636	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|inhibitor inhibitor|amod|END_ENTITY	-LSB- Effect of angiotensin_converting_enzyme inhibitor lisinopril on sympathetic heart rate response during exercise in the early phase of acute myocardial_infarction -RSB- .
12372680	0	lisinopril	72,82	angiotensin_converting_enzyme	28,57	lisinopril	angiotensin converting enzyme	MESH:D017706	1636	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|effects effects|nmod|END_ENTITY	Antihypertensive effects of angiotensin_converting_enzyme inhibition by lisinopril in post-transplant patients .
1653792	0	lisinopril	156,166	angiotensin_converting_enzyme	15,44	lisinopril	angiotensin converting enzyme	MESH:D017706	1636	Chemical	Gene	treatment|amod|START_ENTITY induction|nmod|treatment Measurement|dep|induction Measurement|nmod|induction induction|amod|END_ENTITY	Measurement of angiotensin_converting_enzyme induction and inhibition using quantitative in vitro autoradiography : tissue selective induction after chronic lisinopril treatment .
2559191	0	lisinopril	113,123	angiotensin_converting_enzyme	45,74	lisinopril	angiotensin converting enzyme	MESH:D017706	24310(Tax:10116)	Chemical	Gene	mechanism|dep|START_ENTITY mechanism|nmod|inhibitors inhibitors|compound|END_ENTITY	Intestinal absorption mechanism of dipeptide angiotensin_converting_enzyme inhibitors of the lysyl-proline type : lisinopril and SQ 29,852 .
2822304	0	lisinopril	94,104	angiotensin_converting_enzyme	12,41	lisinopril	angiotensin converting enzyme	MESH:D017706	24310(Tax:10116)	Chemical	Gene	administration|amod|START_ENTITY brain|nmod|administration organs|nmod|brain END_ENTITY|nmod|organs	Blockade of angiotensin_converting_enzyme in circumventricular organs of the brain after oral lisinopril administration demonstrated by quantitative in vitro autoradiography .
2822313	0	lisinopril	87,97	angiotensin_converting_enzyme	20,49	lisinopril	angiotensin converting enzyme	MESH:D017706	24310(Tax:10116)	Chemical	Gene	Pharmacokinetics|nmod|START_ENTITY Pharmacokinetics|nmod|inhibition inhibition|amod|END_ENTITY	Pharmacokinetics of angiotensin_converting_enzyme inhibition in tissues following oral lisinopril : studies in the rat using quantitative radioinhibitor binding .
2846685	0	lisinopril	56,66	angiotensin_converting_enzyme	15,44	lisinopril	angiotensin converting enzyme	MESH:D017706	24310(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Effects of the angiotensin_converting_enzyme inhibitor , lisinopril , on normal and diabetic rats .
2853446	1	lisinopril	99,109	angiotensin_converting_enzyme	55,84	lisinopril	angiotensin converting enzyme	MESH:D017706	1636	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|Influence Influence|nmod|END_ENTITY	Influence of angiotensin_converting_enzyme inhibition by lisinopril .
3033998	0	lisinopril	41,51	angiotensin_converting_enzyme	59,88	lisinopril	angiotensin converting enzyme	MESH:D017706	1636	Chemical	Gene	effects|nmod|START_ENTITY inhibitor|nsubj|effects inhibitor|nsubj|END_ENTITY	Antihypertensive and hormonal effects of lisinopril , a new angiotensin_converting_enzyme -LRB- ACE -RRB- inhibitor in patients with renovascular_hypertension .
7674133	0	lisinopril	96,106	angiotensin_converting_enzyme	55,84	lisinopril	angiotensin converting enzyme	MESH:D017706	100715217	Chemical	Gene	analysis|dep|START_ENTITY analysis|nmod|reactions reactions|nmod|inhibitor inhibitor|amod|END_ENTITY	Toxicodynamic analysis of inflammatory reactions by an angiotensin_converting_enzyme inhibitor -LRB- lisinopril -RRB- in guinea-pig skin .
17512521	0	lisinopril	53,63	matrix_metalloproteinase-9	14,40	lisinopril	matrix metalloproteinase-9	MESH:D017706	4318	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Inhibition of matrix_metalloproteinase-9 activity by lisinopril after myocardial_infarction in hamsters .
3336541	0	lisuride	78,86	Prolactin	0,9	lisuride	Prolactin	MESH:D008090	5617	Chemical	Gene	patterns|nmod|START_ENTITY tests|dep|patterns tests|amod|END_ENTITY	Prolactin stimulation tests : different response patterns after bromocriptine , lisuride , and metergoline treatment of puerperal women .
8200605	1	lisuride	121,129	interferon-gamma	65,81	lisuride	interferon-gamma	MESH:D008090	3458	Chemical	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Increased interferon-gamma production with the dopaminergic agent lisuride -RSB- .
386688	0	lisuride	38,46	prolactin	15,24	lisuride	prolactin	MESH:D008090	5617	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Suppression Suppression|nmod|END_ENTITY	Suppression of prolactin secretion by lisuride throughout the menstrual cycle and in hyperprolactinaemic_menstrual_disorders .
4039514	0	lisuride	46,54	prolactin	56,65	lisuride	prolactin	MESH:D008090	5617	Chemical	Gene	dosages|nmod|START_ENTITY inhibition|nmod|dosages Lactation|acl|inhibition Lactation|dep|secretion secretion|compound|END_ENTITY	-LSB- Lactation inhibition with various dosages of lisuride -- prolactin secretion and effectiveness -RSB- .
508675	0	lisuride	10,18	prolactin	56,65	lisuride	prolactin	MESH:D008090	5617	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of lisuride on inhibition of lactation and serum prolactin .
7308272	0	lisuride	27,35	prolactin	136,145	lisuride	prolactin	MESH:D008090	5617	Chemical	Gene	Radioimmunoassay|nmod|START_ENTITY Radioimmunoassay|dep|effect effect|nmod|level level|compound|END_ENTITY	Radioimmunoassay of plasma lisuride in man following intravenous and oral administration of lisuride hydrogen_maleate : effect on plasma prolactin level .
7308272	0	lisuride	92,100	prolactin	136,145	lisuride	prolactin	MESH:D008090	5617	Chemical	Gene	hydrogen_maleate|amod|START_ENTITY administration|nmod|hydrogen_maleate man|nmod|administration lisuride|nmod|man Radioimmunoassay|nmod|lisuride Radioimmunoassay|dep|effect effect|nmod|level level|compound|END_ENTITY	Radioimmunoassay of plasma lisuride in man following intravenous and oral administration of lisuride hydrogen_maleate : effect on plasma prolactin level .
10090644	0	lithium	28,35	5-HT1B	39,45	lithium	5-HT1B	MESH:D008094	15551(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|receptors receptors|nummod|END_ENTITY	Evidence of the activity of lithium on 5-HT1B receptors in the mouse forced swimming test : comparison with carbamazepine and sodium_valproate .
21389981	0	lithium	36,43	AKT	0,3	lithium	AKT	MESH:D008094	11651(Tax:10090)	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|activity activity|compound|END_ENTITY	AKT kinase activity is required for lithium to modulate mood-related behaviors in mice .
10405156	4	lithium	597,604	A_beta	779,785	lithium	A beta	MESH:D008094	54226(Tax:10116)	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|nmod|sites sites|acl|recognized recognized|nmod|antibodies antibodies|acl:relcl|occurs occurs|advcl|incubated incubated|nmod|END_ENTITY	Here we report that lithium prevents the enhanced phosphorylation of tau protein at the sites recognized by antibodies Tau-1 and PHF-1 which occurs when cultured rat cortical neurons are incubated with A_beta .
12878481	0	lithium	22,29	Akt	52,55	lithium	Akt	MESH:D008094	24185(Tax:10116)	Chemical	Gene	signaling|nmod|START_ENTITY Myogenic|acl|signaling END_ENTITY|nsubjpass|Myogenic	Myogenic signaling by lithium in cardiomyoblasts is Akt independent but requires activation of the beta-catenin-Tcf/Lef pathway .
23082110	0	lithium	130,137	Akt	22,25	lithium	Akt	MESH:D008094	11651(Tax:10090)	Chemical	Gene	treatment|compound|START_ENTITY restoration|nmod|treatment regulation|appos|restoration regulation|nmod|signaling signaling|compound|END_ENTITY	Altered regulation of Akt signaling with murine cerebral_malaria , effects on long-term neuro-cognitive function , restoration with lithium treatment .
12817904	0	lithium	24,31	Aquaporin-2	50,61	lithium	Aquaporin-2	MESH:D008094	359	Chemical	Gene	Effect|nmod|START_ENTITY intake|nsubj|Effect intake|nmod|END_ENTITY	Effect of an acute oral lithium intake on urinary Aquaporin-2 in healthy humans with and without simultaneous stimulation with hypertonic saline infusion .
17448124	0	lithium	22,29	BDNF	53,57	lithium	BDNF	MESH:D008094	24225(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY treatment|nmod|END_ENTITY	Effects of subchronic lithium treatment on levels of BDNF , Bcl-2 and phospho-CREB in the rat hippocampus .
19018715	0	lithium	83,90	BDNF	27,31	lithium	BDNF	MESH:D008094	627	Chemical	Gene	response|compound|START_ENTITY polymorphisms|nmod|response polymorphisms|nsubj|studies studies|nmod|END_ENTITY	Association studies of the BDNF and the NTRK2 gene polymorphisms with prophylactic lithium response in bipolar patients .
19276559	0	lithium	40,47	BDNF	12,16	lithium	BDNF	MESH:D008094	627	Chemical	Gene	concentration|nmod|START_ENTITY concentration|amod|END_ENTITY	Increase of BDNF serum concentration in lithium treated patients with early Alzheimer 's _ disease .
21803112	0	lithium	21,28	BDNF	88,92	lithium	BDNF	MESH:D008094	627	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|production production|appos|END_ENTITY	Divergent effects of lithium and sodium_valproate on brain-derived_neurotrophic_factor -LRB- BDNF -RRB- production in human astrocytoma cells at therapeutic concentrations .
24699060	0	lithium	11,18	BDNF	40,44	lithium	BDNF	MESH:D008094	627	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|protein protein|compound|END_ENTITY	Effects of lithium and valproic_acid on BDNF protein and gene expression in an in vitro human neuron-like model of degeneration .
25012431	0	lithium	157,164	BDNF	15,19	lithium	BDNF	MESH:D008094	627	Chemical	Gene	role|nmod|START_ENTITY levels|dep|role serum|dobj|levels serum|nsubj|Alterations Alterations|nmod|END_ENTITY	Alterations in BDNF -LRB- brain_derived_neurotrophic_factor -RRB- and GDNF -LRB- glial_cell_line-derived_neurotrophic_factor -RRB- serum levels in bipolar_disorder : The role of lithium .
25945236	0	lithium	29,36	BDNF	40,44	lithium	BDNF	MESH:D008094	24225(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|mRNA mRNA|compound|END_ENTITY	Acute and chronic effects of lithium on BDNF and GDNF mRNA and protein levels in rat primary neuronal , astroglial and neuroastroglia cultures .
25945236	0	lithium	29,36	BDNF	40,44	lithium	BDNF	MESH:D008094	24225(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|mRNA mRNA|compound|END_ENTITY	Acute and chronic effects of lithium on BDNF and GDNF mRNA and protein levels in rat primary neuronal , astroglial and neuroastroglia cultures .
14653110	0	lithium	12,19	Bcl-2	80,85	lithium	Bcl-2	MESH:D008094	24224(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|dep|signal signal|nmod|proteins proteins|compound|END_ENTITY	-LSB- Effects of lithium on the activity of ERK-1 / 2 signal pathway and expression of Bcl-2 family proteins in the central nervous system in vivo -RSB- .
15111020	0	lithium	112,119	Bcl-2	137,142	lithium	Bcl-2	MESH:D008094	12043(Tax:10090)	Chemical	Gene	mice|nmod|START_ENTITY Prevention|nmod|mice Prevention|dep|involvements involvements|nmod|END_ENTITY	Prevention of MPTP -LRB- N-methyl-4-phenyl-1 ,2,3,6 - tetrahydropyridine -RRB- dopaminergic neurotoxicity in mice by chronic lithium : involvements of Bcl-2 and Bax .
17448124	0	lithium	22,29	Bcl-2	59,64	lithium	Bcl-2	MESH:D008094	24224(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY treatment|amod|END_ENTITY	Effects of subchronic lithium treatment on levels of BDNF , Bcl-2 and phospho-CREB in the rat hippocampus .
18257969	0	lithium	83,90	Bcl-2	106,111	lithium	Bcl-2	MESH:D008094	12043(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|compound|END_ENTITY	Neuroactive steroids , mood stabilizers , and neuroplasticity : alterations following lithium and changes in Bcl-2 knockout mice .
24018547	0	lithium	100,107	Brain-derived_neurotrophic_factor	0,33	lithium	Brain-derived neurotrophic factor	MESH:D008094	627	Chemical	Gene	augmentation|compound|START_ENTITY increase|nmod|augmentation increase|nsubj|concentrations concentrations|amod|END_ENTITY	Brain-derived_neurotrophic_factor serum concentrations in acute depressive patients increase during lithium augmentation of antidepressants .
9165496	0	lithium	87,94	C-fos	21,26	lithium	C-fos	MESH:D008094	314322(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY expression|dep|effect expression|compound|END_ENTITY	Basal and stimulated C-fos mRNA expression in the rat brain : effect of chronic dietary lithium .
11281956	0	lithium	42,49	Dopamine_receptor_D3	0,20	lithium	Dopamine receptor D3	MESH:D008094	1814	Chemical	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Dopamine_receptor_D3 gene and response to lithium prophylaxis in mood_disorders .
19330793	0	lithium	67,74	FYN	31,34	lithium	FYN	MESH:D008094	2534	Chemical	Gene	response|compound|START_ENTITY END_ENTITY|nmod|response	The association study of three FYN polymorphisms with prophylactic lithium response in bipolar patients .
10321456	0	lithium	14,21	Fos	58,61	lithium	Fos	MESH:D008094	314322(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|compound|END_ENTITY	The effect of lithium on methamphetamine-induced regional Fos protein expression in the rat brain .
21875410	0	lithium	13,20	GDNF	34,38	lithium	GDNF	MESH:D008094	2668	Chemical	Gene	treatment|compound|START_ENTITY treatment|nmod|END_ENTITY	Influence of lithium treatment on GDNF serum and CSF concentrations in patients with early Alzheimer 's _ disease .
15475000	0	lithium	24,31	GSK-3beta	0,9	lithium	GSK-3beta	MESH:D008094	2932	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	GSK-3beta inhibition by lithium confers resistance to chemotherapy-induced apoptosis through the repression of CD95 -LRB- Fas/APO -1 -RRB- expression .
19754466	0	lithium	40,47	GSK3	11,15	lithium	GSK3	MESH:D008094	56637(Tax:10090)	Chemical	Gene	action|compound|START_ENTITY target|nmod|action an|nmod|target END_ENTITY|dep|an	Validating GSK3 as an in vivo target of lithium action .
11641213	4	lithium	748,755	GSK3beta	736,744	lithium	gsk3beta	MESH:D008094	30654(Tax:7955)	Chemical	Gene	Xgsk3beta|compound|START_ENTITY showed|nmod|Xgsk3beta showed|nmod|inhibition inhibition|nmod|END_ENTITY	Heterozygous mbl embryos showed increased sensitivity to inhibition of GSK3beta by lithium or dn Xgsk3beta that led to the loss_of_eyes .
21876507	0	lithium	56,63	Glucocorticoid_receptor	0,23	lithium	Glucocorticoid receptor	MESH:D008094	2908	Chemical	Gene	response|compound|START_ENTITY associated|nmod|response associated|nsubjpass|polymorphism polymorphism|compound|END_ENTITY	Glucocorticoid_receptor polymorphism is associated with lithium response in bipolar patients .
23021822	0	lithium	121,128	Glycogen_synthase_kinase_3b	0,27	lithium	Glycogen synthase kinase 3b	MESH:D008094	2932	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|polymorphisms polymorphisms|amod|END_ENTITY	Glycogen_synthase_kinase_3b gene polymorphisms may be associated with bipolar_I_disorder and the therapeutic response to lithium .
25239564	0	lithium	167,174	Glycogen_synthase_kinase_3b	0,27	lithium	Glycogen synthase kinase 3b	MESH:D008094	56637(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY implications|nmod|effect activity|dep|implications modulating|dobj|activity dictates|advcl|modulating dictates|nsubj|END_ENTITY	Glycogen_synthase_kinase_3b dictates podocyte motility and focal adhesion turnover by modulating paxillin activity : implications for the protective effect of low-dose lithium in podocytopathy .
1337888	0	lithium	22,29	IL-2	33,37	lithium	IL-2	MESH:D008094	3558	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	-LSB- Modulation effect of lithium on IL-2 and IFNr production by human peripheral blood mononuclear cells -RSB- .
16738484	0	lithium	72,79	Insulin-like_growth_factor_binding_protein-2	0,44	lithium	Insulin-like growth factor binding protein-2	MESH:D008094	3485	Chemical	Gene	decreased|nmod|START_ENTITY decreased|nsubjpass|expression expression|amod|END_ENTITY	Insulin-like_growth_factor_binding_protein-2 expression is decreased by lithium .
8384505	0	lithium	30,37	M3-muscarinic_acetylcholine_receptors	75,112	lithium	M3-muscarinic acetylcholine receptors	MESH:D008094	1131	Chemical	Gene	treatment|compound|START_ENTITY effects|nmod|treatment effects|nmod|END_ENTITY	Long-term biphasic effects of lithium treatment on phospholipase C-coupled M3-muscarinic_acetylcholine_receptors in cultured cerebellar granule cells .
26441681	0	lithium	15,22	NFAT5	26,31	lithium	NFAT5	MESH:D008094	10725	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|compound|END_ENTITY	Dual effect of lithium on NFAT5 activity in kidney cells .
15582669	0	lithium	8,15	Nurr1	26,31	lithium	Nurr1	MESH:D008094	54278(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|amod|END_ENTITY	Chronic lithium decreases Nurr1 expression in the rat brain and impairs spatial discrimination .
7491404	0	lithium	32,39	PKC_alpha	19,28	lithium	PKC alpha	MESH:D008094	5578	Chemical	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|nmod|END_ENTITY	Down-regulation of PKC_alpha by lithium in vitro .
616064	0	lithium	36,43	Parathyroid_hormone	0,19	lithium	Parathyroid hormone	MESH:D008094	5741	Chemical	Gene	therapy|compound|START_ENTITY END_ENTITY|nmod|therapy	Parathyroid_hormone in serum during lithium therapy .
11913731	0	lithium	43,50	Serotonin_transporter	0,21	lithium	Serotonin transporter	MESH:D008094	6532	Chemical	Gene	prophylaxis|compound|START_ENTITY associated|nmod|prophylaxis associated|nsubj|gene gene|amod|END_ENTITY	Serotonin_transporter gene associated with lithium prophylaxis in mood_disorders .
18349701	0	lithium	43,50	Serotonin_transporter	0,21	lithium	Serotonin transporter	MESH:D008094	6532	Chemical	Gene	augmentation|compound|START_ENTITY END_ENTITY|nmod|augmentation	Serotonin_transporter gene and response to lithium augmentation in depression .
21310903	0	lithium	35,42	TGFBIp	14,20	lithium	TGFBIp	MESH:D008094	7045	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Inhibition of TGFBIp expression by lithium : implications for TGFBI-linked_corneal_dystrophy therapy .
24803542	0	lithium	106,113	TNF-a	0,5	lithium	TNF-a	MESH:D008094	7124	Chemical	Gene	role|nmod|START_ENTITY expression|dep|role expression|amod|END_ENTITY	TNF-a expression in neutrophils and its regulation by glycogen synthase kinase-3 : a potentiating role for lithium .
2402178	0	lithium	19,26	acetylcholinesterase	60,80	lithium	acetylcholinesterase	MESH:D008094	83817(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY Effects|nmod|administration END_ENTITY|nsubj|Effects	Effects of chronic lithium administration on brain weights , acetylcholinesterase activity and learning ability in rats .
9930766	0	lithium	28,35	bcl-2	110,115	lithium	bcl-2	MESH:D008094	596	Chemical	Gene	increase|nsubj|START_ENTITY increase|xcomp|END_ENTITY	The mood-stabilizing agents lithium and valproate robustly increase the levels of the neuroprotective protein bcl-2 in the CNS .
11685390	0	lithium	8,15	brain-derived_neurotrophic_factor	54,87	lithium	brain-derived neurotrophic factor	MESH:D008094	24225(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY increases|nsubj|treatment increases|dobj|expression expression|nmod|END_ENTITY	Chronic lithium treatment increases the expression of brain-derived_neurotrophic_factor in the rat brain .
16025419	0	lithium	13,20	brain-derived_neurotrophic_factor	54,87	lithium	brain-derived neurotrophic factor	MESH:D008094	627	Chemical	Gene	START_ENTITY|dobj|response response|nmod|gene gene|amod|END_ENTITY	Prophylactic lithium response and polymorphism of the brain-derived_neurotrophic_factor gene .
17925795	0	lithium	21,28	brain-derived_neurotrophic_factor	83,116	lithium	brain-derived neurotrophic factor	MESH:D008094	24225(Tax:10116)	Chemical	Gene	activate|nsubj|START_ENTITY activate|dobj|IV IV|nmod|END_ENTITY	The mood stabilizers lithium and valproate selectively activate the promoter IV of brain-derived_neurotrophic_factor in neurons .
19300599	0	lithium	110,117	brain-derived_neurotrophic_factor	19,52	lithium	brain-derived neurotrophic factor	MESH:D008094	627	Chemical	Gene	addition|compound|START_ENTITY responding|nmod|addition patients|acl|responding Increase|nmod|patients Increase|nmod|levels levels|compound|END_ENTITY	Increase of plasma brain-derived_neurotrophic_factor levels in two psychotic_depressed patients responding to lithium addition to paroxetine treatment .
19486334	0	lithium	33,40	brain-derived_neurotrophic_factor	69,102	lithium	brain-derived neurotrophic factor	MESH:D008094	627	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|nmod|protein protein|amod|END_ENTITY	Effects of 4-week treatment with lithium and olanzapine on levels of brain-derived_neurotrophic_factor , B-cell_CLL / lymphoma_2 and phosphorylated_cyclic_adenosine_monophosphate response element-binding protein in the sub-regions of the hippocampus .
20714172	0	lithium	85,92	brain-derived_neurotrophic_factor	6,39	lithium	brain-derived neurotrophic factor	MESH:D008094	627	Chemical	Gene	therapy|compound|START_ENTITY END_ENTITY|nmod|therapy	Serum brain-derived_neurotrophic_factor in euthymic bipolar patients on prophylactic lithium therapy .
21803112	0	lithium	21,28	brain-derived_neurotrophic_factor	53,86	lithium	brain-derived neurotrophic factor	MESH:D008094	627	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|production production|amod|END_ENTITY	Divergent effects of lithium and sodium_valproate on brain-derived_neurotrophic_factor -LRB- BDNF -RRB- production in human astrocytoma cells at therapeutic concentrations .
8787041	0	lithium	16,23	c-fos	39,44	lithium	c-fos	MESH:D008094	314322(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Chronic dietary lithium inhibits basal c-fos mRNA expression in rat brain .
1248601	0	lithium	17,24	ceruloplasmin	34,47	lithium	ceruloplasmin	MESH:D008094	12870(Tax:10090)	Chemical	Gene	influence|nmod|START_ENTITY influence|nmod|END_ENTITY	The influence of lithium on serum ceruloplasmin .
17367908	0	lithium	11,18	citrate_synthase	48,64	lithium	citrate synthase	MESH:D008094	170587(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of lithium and valproate on hippocampus citrate_synthase activity in an animal model of mania .
7790856	0	lithium	19,26	cyclic_AMP	89,99	lithium	cyclic AMP	MESH:D008094	316010(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY Effects|nmod|treatment Effects|nmod|END_ENTITY	Effects of chronic lithium treatment on agonist-enhanced extracellular concentrations of cyclic_AMP in the dorsal hippocampus of freely moving rats .
1674966	0	lithium	23,30	fos	34,37	lithium	fos	MESH:D008094	314322(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Differential effect of lithium on fos protooncogene expression mediated by receptor and postreceptor activators of protein_kinase_C and cyclic_adenosine_monophosphate : model for its antimanic action .
2119851	0	lithium	118,125	fos	17,20	lithium	fos	MESH:D008094	314322(Tax:10116)	Chemical	Gene	action|nmod|START_ENTITY implications|nmod|action expression|dep|implications expression|compound|END_ENTITY	Lithium augments fos protoonocogene expression in PC12 pheochromocytoma cells : implications for therapeutic action of lithium .
18313644	0	lithium	11,18	glycogen_synthase_kinase-3beta	56,86	lithium	glycogen synthase kinase-3beta	MESH:D008094	418335(Tax:9031)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|acl|END_ENTITY	Effects of lithium and deafferentation on expression of glycogen_synthase_kinase-3beta , NFkappaB , beta-catenin and pCreb in the chick cochlear nucleus .
24070631	0	lithium	56,63	glycogen_synthase_kinase_3b	14,41	lithium	glycogen synthase kinase 3b	MESH:D008094	2932	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Inhibition of glycogen_synthase_kinase_3b activity with lithium prevents and attenuates paclitaxel-induced neuropathic_pain .
12378122	0	lithium	51,58	leptin	22,28	lithium	leptin	MESH:D008094	3952	Chemical	Gene	treatment|compound|START_ENTITY levels|nmod|treatment levels|compound|END_ENTITY	Weight_gain and serum leptin levels in patients on lithium treatment .
7478221	0	lithium	35,42	neuropeptide_Y	61,75	lithium	neuropeptide Y	MESH:D008094	24604(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY administration|nmod|expression expression|compound|END_ENTITY	Region-specific effects of chronic lithium administration on neuropeptide_Y and somatostatin mRNA expression in the rat brain .
17512948	0	lithium	11,18	neurotrophin-3	58,72	lithium	neurotrophin-3	MESH:D008094	81737(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|amod|END_ENTITY	Effects of lithium and valproate on serum and hippocampal neurotrophin-3 levels in an animal model of mania .
18158645	0	lithium	82,89	p38	18,21	lithium	p38	MESH:D008094	81649(Tax:10116)	Chemical	Gene	MAPK|nmod|START_ENTITY MAPK|nsubj|role role|nmod|END_ENTITY	Essential role of p38 MAPK for activation of skeletal muscle glucose transport by lithium .
2170960	0	lithium	133,140	parathyroid_hormone	83,102	lithium	parathyroid hormone	MESH:D008094	5741	Chemical	Gene	administration|compound|START_ENTITY resistance|nmod|administration resistance|amod|END_ENTITY	Persistent nephrogenic_diabetes_insipidus , tubular proteinuria , aminoaciduria , and parathyroid_hormone resistance following longterm lithium administration .
26229473	0	lithium	23,30	parathyroid_hormone	50,69	lithium	parathyroid hormone	MESH:D008094	5741	Chemical	Gene	treatment|compound|START_ENTITY treatment|nmod|END_ENTITY	Effects of maintenance lithium treatment on serum parathyroid_hormone and calcium levels : a retrospective longitudinal naturalistic study .
3587184	0	lithium	10,17	parathyroid_hormone	47,66	lithium	parathyroid hormone	MESH:D008094	280903(Tax:9913)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|acl|END_ENTITY	Effect of lithium on the metabolic response to parathyroid_hormone .
6301744	0	lithium	87,94	parathyroid_hormone	44,63	lithium	parathyroid hormone	MESH:D008094	280903(Tax:9913)	Chemical	Gene	therapy|compound|START_ENTITY patients|nmod|therapy END_ENTITY|nmod|patients	Impairment of cyclic_AMP response to bovine parathyroid_hormone in patients on chronic lithium therapy with diminished renal urine-concentrating ability .
6323091	0	lithium	64,71	parathyroid_hormone	24,43	lithium	parathyroid hormone	MESH:D008094	5741	Chemical	Gene	treatment|compound|START_ENTITY responses|nmod|treatment responses|nmod|END_ENTITY	Cyclic_AMP responses to parathyroid_hormone and glucagon during lithium treatment .
6330156	0	lithium	25,32	parathyroid_hormone	70,89	lithium	parathyroid hormone	MESH:D008094	5741	Chemical	Gene	START_ENTITY|nmod|suppressibility suppressibility|nmod|secretion secretion|amod|END_ENTITY	The effect of short term lithium administration on suppressibility of parathyroid_hormone secretion by calcium in vivo .
9784918	0	lithium	6,13	parathyroid_hormone	51,70	lithium	parathyroid hormone	MESH:D008094	24694(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY impairs|nsubj|administration impairs|dobj|action action|nmod|END_ENTITY	Acute lithium administration impairs the action of parathyroid_hormone on rat renal calcium , magnesium and phosphate transport .
11294478	0	lithium	31,38	prolactin	58,67	lithium	prolactin	MESH:D008094	5617	Chemical	Gene	treatment|compound|START_ENTITY Effects|nmod|treatment Effects|nmod|levels levels|compound|END_ENTITY	Effects of short and long-term lithium treatment on serum prolactin levels in patients with bipolar_affective_disorder .
3126532	0	lithium	111,118	prolactin	80,89	lithium	prolactin	MESH:D008094	24683(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY rat|nmod|administration END_ENTITY|nmod|rat	Activity of tuberoinfundibular dopaminergic neurons and concentrations of serum prolactin in the rat following lithium administration .
508205	0	lithium	17,24	prolactin	95,104	lithium	prolactin	MESH:D008094	24683(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY reflected|nsubj|effects reflected|nmod|inhibition inhibition|nmod|secretion secretion|compound|END_ENTITY	Acute effects of lithium on central dopamine and serotonin activity reflected by inhibition of prolactin and growth_hormone secretion in the rat .
6320308	0	lithium	8,15	prolactin	63,72	lithium	prolactin	MESH:D008094	24683(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY treatment|nmod|END_ENTITY	Chronic lithium treatment and twenty-four hour rhythm of serum prolactin , growth_hormone and melatonin in rats .
8373918	0	lithium	10,17	prolactin	25,34	lithium	prolactin	MESH:D008094	5617	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|response response|compound|END_ENTITY	Effect of lithium on the prolactin response to D-fenfluramine in healthy subjects .
895996	0	lithium	24,31	prolactin	7,16	lithium	prolactin	MESH:D008094	5617	Chemical	Gene	treatment|compound|START_ENTITY END_ENTITY|nmod|treatment	Plasma prolactin during lithium treatment .
7908521	0	lithium	16,23	pyroglutamyl-aminopeptidase_I	42,71	lithium	pyroglutamyl-aminopeptidase I	MESH:D008094	290648(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY administration|nmod|activity activity|compound|END_ENTITY	Effect of acute lithium administration on pyroglutamyl-aminopeptidase_I activity in several brain areas of the rat .
355180	0	lithium	34,41	renin	7,12	lithium	renin	MESH:D008094	5972	Chemical	Gene	therapy|compound|START_ENTITY END_ENTITY|nmod|therapy	Plasma renin concentration during lithium therapy .
591245	0	lithium	30,37	renin	7,12	lithium	renin	MESH:D008094	5972	Chemical	Gene	treatment|compound|START_ENTITY substrate|nmod|treatment substrate|nsubj|END_ENTITY	Plasma renin substrate during lithium treatment .
6337661	0	lithium	17,24	renin	48,53	lithium	renin	MESH:D008094	5972	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|compound|END_ENTITY	Direct effect of lithium on active and inactive renin secretion .
873719	0	lithium	29,36	renin	7,12	lithium	renin	MESH:D008094	5972	Chemical	Gene	treatment|compound|START_ENTITY END_ENTITY|nmod|treatment	Plasma renin activity during lithium treatment of patients .
15849387	0	lithium	23,30	serotonin_transporter	78,99	lithium	serotonin transporter	MESH:D008094	6532	Chemical	Gene	effect|nmod|START_ENTITY related|nsubjpass|effect related|nmod|genotype genotype|compound|END_ENTITY	Prophylactic effect of lithium in bipolar affective illness may be related to serotonin_transporter genotype .
17360901	0	lithium	61,68	serotonin_transporter	31,52	lithium	serotonin transporter	MESH:D008094	6532	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Differential regulation of the serotonin_transporter gene by lithium is mediated by transcription factors , CCCTC binding protein and Y-box_binding_protein_1 , through the polymorphic intron 2 variable number tandem repeat .
17373693	0	lithium	12,19	serotonin_transporter	53,74	lithium	serotonin transporter	MESH:D008094	6532	Chemical	Gene	prophylaxis|compound|START_ENTITY Response|nmod|prophylaxis Response|dep|interaction interaction|nmod|genes genes|compound|END_ENTITY	Response to lithium prophylaxis : interaction between serotonin_transporter and BDNF genes .
6782601	0	lithium	10,17	thyrotropin_releasing_hormone	44,73	lithium	thyrotropin releasing hormone	MESH:D008094	7200	Chemical	Gene	Effect|nmod|START_ENTITY Effect|acl|END_ENTITY	Effect of lithium on prolactin responses to thyrotropin_releasing_hormone in patients with manic state .
3108170	0	lithium_carbonate	24,41	insulin	71,78	lithium carbonate	insulin	MESH:D016651	3630	Chemical	Gene	administration|compound|START_ENTITY administration|nmod|END_ENTITY	Influence of short-term lithium_carbonate administration on stimulated insulin secretion in normal man .
1337282	0	lithium_chloride	69,85	C-fos	0,5	lithium chloride	C-fos	MESH:D018021	314322(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	C-fos expression in the rat brain after intraperitoneal injection of lithium_chloride .
9625354	0	lithium_chloride	189,205	c-Fos	164,169	lithium chloride	c-Fos	MESH:D018021	314322(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY protein|acl|induced protein|amod|END_ENTITY	Separate populations of neurons within the paraventricular hypothalamic nucleus of the rat project to vagal and thoracic autonomic preganglionic levels and express c-Fos protein induced by lithium_chloride .
11589989	0	lithium_chloride	70,86	c-fos	12,17	lithium chloride	c-fos	MESH:D018021	314322(Tax:10116)	Chemical	Gene	injection|amod|START_ENTITY Dynamics|nmod|injection Dynamics|nmod|END_ENTITY	Dynamics of c-fos and ICER mRNA expression in rat forebrain following lithium_chloride injection .
8233031	0	lithium_chloride	76,92	c-fos	14,19	lithium chloride	c-fos	MESH:D018021	314322(Tax:10116)	Chemical	Gene	pressure|amod|START_ENTITY nauseant|dobj|pressure subcortical|xcomp|nauseant subcortical|nsubj|Expression Expression|nmod|END_ENTITY	Expression of c-fos in brain subcortical structures in response to nauseant lithium_chloride and osmotic pressure in rats .
22739176	0	lithium_chloride	23,39	cyclosporine_A	54,68	lithium chloride	cyclosporine A	MESH:D018021	71991(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY combined|nsubj|effect combined|nmod|END_ENTITY	-LSB- Therapeutic effect of lithium_chloride combined with cyclosporine_A on mouse model with aplastic_anemia -RSB- .
1337310	0	lithium_chloride	10,26	ornithine_decarboxylase	30,53	lithium chloride	ornithine decarboxylase	MESH:D018021	24609(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	Effect of lithium_chloride on ornithine_decarboxylase activity in rat adrenal .
1847813	0	lithium_chloride	26,42	ornithine_decarboxylase	46,69	lithium chloride	ornithine decarboxylase	MESH:D018021	4953	Chemical	Gene	Control|nmod|START_ENTITY Control|nmod|END_ENTITY	Control by treatment with lithium_chloride of ornithine_decarboxylase in Ehrlich_ascites_tumor cells .
2167419	0	lithium_chloride	69,85	ornithine_decarboxylase	33,56	lithium chloride	ornithine decarboxylase	MESH:D018021	24609(Tax:10116)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activity activity|compound|END_ENTITY	Inhibition of hormone-stimulated ornithine_decarboxylase activity by lithium_chloride .
19299527	0	lithocholic_acid	79,95	CYP3A4	69,75	lithocholic acid	CYP3A4	MESH:D008095	1576	Chemical	Gene	results|amod|START_ENTITY END_ENTITY|nmod|results	Ligand diversity of human and chimpanzee CYP3A4 : activation of human CYP3A4 by lithocholic_acid results from positive selection .
11027140	0	lithocholic_acid	13,29	DNA_polymerase_beta	72,91	lithocholic acid	DNA polymerase beta	MESH:D008095	5423	Chemical	Gene	START_ENTITY|xcomp|binding binding|nmod|domain domain|nmod|END_ENTITY	Structure of lithocholic_acid binding to the N-terminal 8-kDa domain of DNA_polymerase_beta .
11686928	0	lithocholic_acid	67,83	DNA_polymerase_beta	101,120	lithocholic acid	DNA polymerase beta	MESH:D008095	5423	Chemical	Gene	site|nmod|START_ENTITY analysis|nmod|site Three-dimensional|dobj|analysis topoisomerase|advcl|Three-dimensional topoisomerase|nsubj|inhibitor inhibitor|nmod|END_ENTITY	Three-dimensional structural model analysis of the binding site of lithocholic_acid , an inhibitor of DNA_polymerase_beta and DNA topoisomerase II .
26597859	0	lobastin	73,81	p38	104,107	lobastin	p38	null	26416(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|downregulation downregulation|nmod|END_ENTITY	Inhibition of VCAM-1 expression on mouse vascular smooth muscle cells by lobastin via downregulation of p38 , ERK_1 / 2 and NF-kB signaling pathways .
26363808	0	lobeglitazone	36,49	PPAR-gamma	16,26	lobeglitazone	PPAR-gamma	MESH:C546215	25664(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|agonist agonist|amod|END_ENTITY	Effect of a new PPAR-gamma agonist , lobeglitazone , on neointimal formation after balloon_injury in rats and the development of atherosclerosis .
22047812	0	lobeglitazone	37,50	peroxisome_proliferator-activated_receptor-y	64,108	lobeglitazone	peroxisome proliferator-activated receptor-y	MESH:C546215	5468	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Tolerability and pharmacokinetics of lobeglitazone -LRB- CKD-501 -RRB- , a peroxisome_proliferator-activated_receptor-y agonist : a single - and multiple-dose , double-blind , randomized control study in healthy male Korean subjects .
20494575	0	lobelane	30,38	VMAT2	65,70	lobelane	VMAT2	MESH:C540157	6571	Chemical	Gene	analogue|compound|START_ENTITY analogue|nmod|END_ENTITY	Quinlobelane : a water-soluble lobelane analogue and inhibitor of VMAT2 .
23875705	0	lobeline	28,36	VMAT2	11,16	lobeline	VMAT2	MESH:D008120	25549(Tax:10116)	Chemical	Gene	inhibitors|dobj|START_ENTITY inhibitors|nsubj|Effects Effects|nmod|END_ENTITY	Effects of VMAT2 inhibitors lobeline and GZ-793A on methamphetamine-induced changes in dopamine release , metabolism and synthesis in vivo .
18593576	0	lodenafil_carbonate	86,105	PDE5	70,74	lodenafil carbonate	PDE5	MESH:C532120	8654	Chemical	Gene	type|amod|START_ENTITY type|appos|END_ENTITY	Pharmacological characterization of a novel phosphodiesterase type 5 -LRB- PDE5 -RRB- inhibitor lodenafil_carbonate on human and rabbit corpus cavernosum .
20428608	0	lodenafil_carbonate	32,51	PDE5	59,63	lodenafil carbonate	PDE5	MESH:C532120	8654	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	-LSB- Cardiovascular repercussion of lodenafil_carbonate , a new PDE5 inhibitor , with and without alcohol consumption -RSB- .
23073140	0	lodenafil_carbonate	28,47	PDE5	81,85	lodenafil carbonate	PDE5	MESH:C532120	8654	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|phosphodiesterase_Type_5 phosphodiesterase_Type_5|appos|END_ENTITY	A Phase I clinical trial of lodenafil_carbonate , a new phosphodiesterase_Type_5 -LRB- PDE5 -RRB- inhibitor , in healthy male volunteers .
23073140	0	lodenafil_carbonate	28,47	phosphodiesterase_Type_5	55,79	lodenafil carbonate	phosphodiesterase Type 5	MESH:C532120	8654	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	A Phase I clinical trial of lodenafil_carbonate , a new phosphodiesterase_Type_5 -LRB- PDE5 -RRB- inhibitor , in healthy male volunteers .
9135403	0	lodoxamide	10,20	eosinophil_cationic_protein	55,82	lodoxamide	eosinophil cationic protein	MESH:C021702	6037	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of lodoxamide and disodium_cromoglycate on tear eosinophil_cationic_protein in vernal_keratoconjunctivitis .
21142219	0	lomefloxacin	38,50	albumin	60,67	lomefloxacin	albumin	MESH:C053091	213	Chemical	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|END_ENTITY	Comparison of binding interactions of lomefloxacin to serum albumin and serum transferrin by resonance light scattering and fluorescence quenching methods .
22925987	0	lomefloxacin	77,89	transferrin	25,36	lomefloxacin	transferrin	MESH:C053091	7018	Chemical	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	Interaction between holo transferrin and HSA-PPIX complex in the presence of lomefloxacin : an evaluation of PPIX aggregation in protein-protein interactions .
17493934	0	lonafarnib	34,44	death_receptor_5	127,143	lonafarnib	death receptor 5	MESH:C115354	8795	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	The farnesyltransferase inhibitor lonafarnib induces CCAAT/enhancer-binding _ protein_homologous_protein-dependent expression of death_receptor_5 , leading to induction of apoptosis in human cancer cells .
20944654	0	lonafarnib	35,45	mTOR	55,59	lonafarnib	mTOR	MESH:C115354	21977(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	The farnesyl transferase inhibitor lonafarnib inhibits mTOR signaling and enforces sorafenib-induced apoptosis in melanoma cells .
2164070	0	lonapalene	38,48	5-lipoxygenase	63,77	lonapalene	5-lipoxygenase	MESH:C045954	240	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|inhibitor inhibitor|amod|END_ENTITY	Pharmacologic and clinical effects of lonapalene -LRB- RS_43179 -RRB- , a 5-lipoxygenase inhibitor , in psoriasis .
8090278	0	loperamide	29,39	ACTH	62,66	loperamide	ACTH	MESH:D008139	5443	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|compound|END_ENTITY	In man the mu-opiate agonist loperamide specifically inhibits ACTH secretion induced by the cholecystokinin-like peptide ceruletide .
16185316	0	loperamide	27,37	mu-Opiate_receptor	0,18	loperamide	mu-Opiate receptor	MESH:D008139	4988	Chemical	Gene	blocks|compound|START_ENTITY blocks|amod|END_ENTITY	mu-Opiate_receptor agonist loperamide blocks bethanechol-induced gallbladder_contraction , despite higher cholecystokinin plasma levels in man .
8877029	0	loperamide	95,105	pancreatic_polypeptide	30,52	loperamide	pancreatic polypeptide	MESH:D008139	5539	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|Suppression Suppression|nmod|END_ENTITY	Suppression of vagus-mediated pancreatic_polypeptide release by the mu-opiate_receptor agonist loperamide in man .
17890284	0	lopinavir	119,128	CD4	141,144	lopinavir	CD4	MESH:D061466	920	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Inhibition of P-glycoprotein and multidrug resistance-associated proteins modulates the intracellular concentration of lopinavir in cultured CD4 T cells and primary human lymphocytes .
25397528	0	lopinavir	133,142	Gag	0,3	lopinavir	Gag	MESH:D061466	155030(Tax:11676)	Chemical	Gene	levels|compound|START_ENTITY END_ENTITY|nmod|levels	Gag drug resistance mutations in HIV-1_subtype_C patients , failing a protease inhibitor inclusive treatment regimen , with detectable lopinavir levels .
15932952	0	loratadine	54,64	cyp2d6	10,16	loratadine	cyp2d6	MESH:D017336	1565	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY allele|nmod|pharmacokinetics allele|nsubj|Effect Effect|nmod|END_ENTITY	Effect of cyp2d6 * 10 allele on the pharmacokinetics of loratadine in chinese subjects .
10936218	0	lorazepam	17,26	MEG	87,90	lorazepam	MEG	MESH:D008140	5775	Chemical	Gene	influence|nmod|START_ENTITY influence|nmod|END_ENTITY	The influence of lorazepam on somatosensory-evoked fast frequency -LRB- 600 Hz -RRB- activity in MEG .
18187530	0	lorazepam	114,123	MK-0343	47,54	lorazepam	MK-0343	MESH:D008140	1477646(Tax:190192)	Chemical	Gene	effects|acl|START_ENTITY effects|nmod|END_ENTITY	Pharmacodynamic and pharmacokinetic effects of MK-0343 , a GABA -LRB- A -RRB- alpha2 ,3 subtype selective agonist , compared to lorazepam and placebo in healthy male volunteers .
8397877	0	lorazepam	45,54	P300	0,4	lorazepam	P300	MESH:D008140	2033	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|dep|effect	P300 in heavy social drinkers : the effect of lorazepam .
2470456	0	lorglumide	39,49	CCK	23,26	lorglumide	CCK	null	25298(Tax:10116)	Chemical	Gene	Effect|amod|START_ENTITY Effect|nmod|END_ENTITY	Effect of a new potent CCK antagonist , lorglumide , on caerulein - and bombesin-induced pancreatic secretion and growth in the rat .
2263169	0	lorglumide	11,21	gastrin	25,32	lorglumide	gastrin	null	25320(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|amod|END_ENTITY	Effects of lorglumide on gastrin - and peptone-stimulated gastric_acid secretion in rats .
15764711	0	lornoxicam	78,88	CYP2C9	8,14	lornoxicam	CYP2C9	MESH:C059451	1559	Chemical	Gene	metabolism|nmod|START_ENTITY Role|nmod|metabolism Role|nmod|END_ENTITY	Role of CYP2C9 and its variants -LRB- CYP2C9 * 3 and CYP2C9 * 13 -RRB- in the metabolism of lornoxicam in humans .
10336919	0	losartan	21,29	ACE	64,67	losartan	ACE	MESH:D019808	1636	Chemical	Gene	improve|nmod|START_ENTITY improve|dobj|effects effects|nmod|inhibitors inhibitors|compound|END_ENTITY	Does the addition of losartan improve the beneficial effects of ACE inhibitors in patients with anterior_myocardial_infarction ?
11850771	0	losartan	71,79	ACE	31,34	losartan	ACE	MESH:D019808	1636	Chemical	Gene	blocked|dobj|START_ENTITY blocked|nsubj|effects effects|nmod|inhibition inhibition|compound|END_ENTITY	Comparative effects of chronic ACE inhibition and AT1 receptor blocked losartan on cardiac_hypertrophy and renal function in hypertensive patients .
12081578	0	losartan	26,34	ACE	77,80	losartan	ACE	MESH:D019808	1636	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|interaction interaction|nmod|genotype genotype|compound|END_ENTITY	Renoprotective effects of losartan in diabetic_nephropathy : interaction with ACE insertion/deletion genotype ?
12222991	0	losartan	14,22	ACE	28,31	losartan	ACE	MESH:D019808	1636	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Comparison of losartan with ACE inhibitors and dihydropyridine_calcium channel antagonists : a pilot study of prescription-event monitoring in Japan .
12716812	0	losartan	36,44	ACE	87,90	losartan	ACE	MESH:D019808	1636	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|interaction interaction|nmod|genotype genotype|compound|END_ENTITY	Long-term renoprotective effects of losartan in diabetic_nephropathy : interaction with ACE insertion/deletion genotype ?
16960460	0	losartan	26,34	ACE	85,88	losartan	ACE	MESH:D019808	1636	Chemical	Gene	effect|nmod|START_ENTITY dependent|nsubj|effect dependent|nmod|polymorphism polymorphism|compound|END_ENTITY	Antiproteinuric effect of losartan in non-diabetic_renal_disease is not dependent on ACE insertion/deletion polymorphism .
24552291	0	losartan	132,140	ACE	63,66	losartan	ACE	MESH:D019808	1636	Chemical	Gene	START_ENTITY|nsubj|design design|acl|combining combining|dobj|captopril captopril|appos|END_ENTITY	A novel design of combining the angiotensin_converting_enzyme -LRB- ACE -RRB- inhibitor captopril with the angiotensin receptor blocker -LRB- ARB -RRB- losartan using homo coupling via PEG diacid linker .
9723827	0	losartan	52,60	ACE	110,113	losartan	ACE	MESH:D019808	1636	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|compound|END_ENTITY	Start of therapy with the angiotensin_II antagonist losartan after immediate switch from pretreatment with an ACE inhibitor .
10483973	0	losartan	48,56	AII	13,16	losartan	AII	MESH:D019808	183	Chemical	Gene	metabolite|nmod|START_ENTITY metabolite|compound|END_ENTITY	EXP3174 , the AII antagonist human metabolite of losartan , but not losartan nor the angiotensin-converting_enzyme inhibitor captopril , prevents the development of lethal_ischemic_ventricular_arrhythmias in a canine model of recent myocardial_infarction .
11819643	0	losartan	36,44	AT1	11,14	losartan	AT1	MESH:D019808	24180(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	Effects of AT1 receptor antagonist , losartan , on rat hepatic_fibrosis induced by CCl -LRB- 4 -RRB- .
12710529	0	losartan	75,83	AT1	129,132	losartan	AT1	MESH:D019808	24180(Tax:10116)	Chemical	Gene	START_ENTITY|dep|role role|nmod|receptors receptors|nummod|END_ENTITY	Angiotensin-II-induced enhanced expression of Gi proteins is attenuated by losartan in A10 vascular smooth muscle cells : role of AT1 receptors .
16714774	0	losartan	29,37	AT1	12,15	losartan	AT1	MESH:D019808	24180(Tax:10116)	Chemical	Gene	receptors|nmod|START_ENTITY receptors|nummod|END_ENTITY	Blockade of AT1 receptors by losartan did not affect renin gene expression in kidney medulla .
22264484	0	losartan	78,86	AT1	136,139	losartan	AT1	MESH:D019808	81638(Tax:10116)	Chemical	Gene	analogue|compound|START_ENTITY analogue|nmod|antagonists antagonists|appos|END_ENTITY	Synthesis and antihypertensive activity of pyrimidin-4 -LRB- 3H -RRB- - one derivatives as losartan analogue for new angiotensin_II_receptor_type_1 -LRB- AT1 -RRB- antagonists .
24374319	0	losartan	66,74	AT1	51,54	losartan	AT1	MESH:D019808	185	Chemical	Gene	START_ENTITY|nsubj|Insights Insights|nmod|basis basis|nmod|action action|nmod|antagonist antagonist|compound|END_ENTITY	Insights into the molecular basis of action of the AT1 antagonist losartan using a combined NMR spectroscopy and computational approach .
7620835	0	losartan	10,18	AT1	23,26	losartan	AT1	MESH:D019808	24180(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Effect of losartan , an AT1 selective angiotensin II receptor antagonist , on isoproterenol-induced cardiac_ornithine_decarboxylase_activity .
7982288	0	losartan	24,32	AT1	36,39	losartan	AT1	MESH:D019808	24180(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|II II|compound|END_ENTITY	Blockade by intravenous losartan of AT1 angiotensin II receptors in rat brain , kidney and adrenals demonstrated by in vitro autoradiography .
9661134	0	losartan	54,62	AT1	15,18	losartan	AT1	MESH:D019808	24180(Tax:10116)	Chemical	Gene	HR_720|acl|START_ENTITY HR_720|compound|END_ENTITY	Effects of the AT1 antagonist HR_720 in comparison to losartan on stimulated sympathetic outflow , blood pressure , and heart rate in pithed spontaneously hypertensive rats .
9719055	0	losartan	140,148	AT1	122,125	losartan	AT1	MESH:D019808	81638(Tax:10116)	Chemical	Gene	blockade|nmod|START_ENTITY blockade|nummod|END_ENTITY	Overexpression of Bax protein and enhanced apoptosis in the left ventricle of spontaneously hypertensive rats : effects of AT1 blockade with losartan .
16113066	9	losartan	1009,1017	AT1_receptor	1035,1047	losartan	AT2 receptor	MESH:D019808	11609(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	ANG_II-evoked increases in preproET-1 mRNA expression and ET-1 release were blocked by losartan -LRB- 100 microM -RRB- , an AT1_receptor antagonist , but not PD-123319 -LRB- 100 microM -RRB- , an AT2_receptor antagonist .
25445371	0	losartan	34,42	AT1_receptor	47,59	losartan	AT1 receptor	MESH:D019808	11610(Tax:10090)	Chemical	Gene	administration|nmod|START_ENTITY administration|appos|antagonist antagonist|amod|END_ENTITY	The intrathecal administration of losartan , an AT1_receptor antagonist , produces an antinociceptive effect through the inhibiton of p38_MAPK phosphorylation in the mouse formalin test .
19164322	0	losartan	160,168	Adiponectin	0,11	losartan	Adiponectin	MESH:D019808	9370	Chemical	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	Adiponectin is positively associated with insulin resistance in subjects with type 2 diabetic_nephropathy and effects of angiotensin II type 1 receptor blocker losartan .
10980590	0	losartan	84,92	Angiotensin_II	0,14	losartan	Angiotensin II	MESH:D019808	183	Chemical	Gene	effect|nmod|START_ENTITY change|dep|effect induce|dobj|change induce|nsubj|END_ENTITY	Angiotensin_II can induce and potentiate shape change in human platelets : effect of losartan .
11967819	0	losartan	4,12	Angiotensin_II	142,156	losartan	Angiotensin II	MESH:D019808	183	Chemical	Gene	study|amod|START_ENTITY study|dep|design design|nmod|RENAAL RENAAL|dep|Reduction Reduction|nmod|NIDDM NIDDM|nmod|Losartan Losartan|compound|END_ENTITY	The losartan renal protection study -- rationale , study design and baseline characteristics of RENAAL -LRB- Reduction of Endpoints in NIDDM with the Angiotensin_II Antagonist Losartan -RRB- .
1527721	0	losartan	75,83	Angiotensin_II	0,14	losartan	Angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|dep|effect	Angiotensin_II and monocrotaline-induced pulmonary_hypertension : effect of losartan -LRB- DuP_753 -RRB- , a nonpeptide angiotensin type 1 receptor antagonist .
18360050	0	losartan	33,41	Angiotensin_II	179,193	losartan	Angiotensin II	MESH:D019808	183	Chemical	Gene	therapy|compound|START_ENTITY Efficacy|nmod|therapy demonstrated|nsubj|Efficacy demonstrated|parataxis|study study|nsubj|Evaluation Evaluation|nmod|Therapy Therapy|compound|END_ENTITY	Efficacy and safety of long-term losartan therapy demonstrated by a prospective observational study in Japanese patients with hypertension : The Japan Hypertension Evaluation with Angiotensin_II Antagonist Losartan Therapy -LRB- J-HEALTH -RRB- study .
21632472	0	losartan	60,68	Angiotensin_II	182,196	losartan	Angiotensin II	MESH:D019808	183	Chemical	Gene	treatment|compound|START_ENTITY outcomes|nmod|treatment uric_acid|nmod|outcomes reduction|nmod|uric_acid Effect|nmod|reduction Effect|dep|analysis analysis|nmod|reduction reduction|nmod|endpoints endpoints|nmod|non-insulin-dependent_diabetes_mellitus non-insulin-dependent_diabetes_mellitus|nmod|Trial Trial|compound|END_ENTITY	Effect of a reduction in uric_acid on renal outcomes during losartan treatment : a post hoc analysis of the reduction of endpoints in non-insulin-dependent_diabetes_mellitus with the Angiotensin_II Antagonist Losartan Trial .
8573552	0	losartan	96,104	Angiotensin_II	0,14	losartan	Angiotensin II	MESH:D019808	183	Chemical	Gene	evaluation|nmod|START_ENTITY rationale|nmod|evaluation antagonists|dep|rationale antagonists|compound|END_ENTITY	Angiotensin_II receptor antagonists in heart_failure : rationale and design of the evaluation of losartan in the elderly -LRB- ELITE -RRB- trial .
8750395	0	losartan	36,44	Angiotensin_II	0,14	losartan	Angiotensin II	MESH:D019808	183	Chemical	Gene	antagonism|dep|START_ENTITY antagonism|compound|END_ENTITY	Angiotensin_II receptor antagonism : losartan - sites and mechanisms of action .
10594793	0	losartan	70,78	Angiotensin_II_type_1_receptor	0,30	losartan	Angiotensin II type 1 receptor	MESH:D019808	185	Chemical	Gene	predicts|nmod|START_ENTITY predicts|nsubj|polymorphism polymorphism|amod|END_ENTITY	Angiotensin_II_type_1_receptor gene polymorphism predicts response to losartan and angiotensin_II .
11867945	0	losartan	43,51	Angiotensin_II_type_1_receptor	0,30	losartan	Angiotensin II type 1 receptor	MESH:D019808	185	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Angiotensin_II_type_1_receptor antagonist , losartan , causes regression of left_ventricular_hypertrophy in end-stage_renal_disease .
20465154	0	losartan	92,100	Angiotensin_II_type_1_receptor	0,30	losartan	Angiotensin II type 1 receptor	MESH:D019808	185	Chemical	Gene	treatment|compound|START_ENTITY influence|nmod|treatment influence|nsubj|polymorphism polymorphism|amod|END_ENTITY	Angiotensin_II_type_1_receptor gene polymorphism could influence renoprotective response to losartan treatment in type 1 diabetic patients with high urinary albumin excretion rate .
15080371	0	losartan	105,113	Angiotensin_converting_enzyme	0,29	losartan	Angiotensin converting enzyme	MESH:D019808	1636	Chemical	Gene	influences|nmod|START_ENTITY influences|nsubj|genotype genotype|amod|END_ENTITY	Angiotensin_converting_enzyme genotype influences the response to the angiotensin II receptor antagonist losartan in patients with hypertension .
16525946	0	losartan	3,11	BNP	54,57	losartan	BNP	MESH:D019808	4879	Chemical	Gene	have|nsubj|START_ENTITY have|dobj|effects effects|nmod|END_ENTITY	Do losartan and atenolol have differential effects on BNP and central haemodynamic parameters ?
18261537	0	losartan	11,19	C-reactive_protein	54,72	losartan	C-reactive protein	MESH:D019808	1401	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of losartan and enalapril on high-sensitivity C-reactive_protein and total antioxidant in renal transplant recipients with Renin-Angiotensin system polymorphisms .
15573910	0	losartan	10,18	CCl4	81,85	losartan	CCl4	MESH:D019808	116637(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY induced|nsubj|Effect induced|nmod|END_ENTITY	Effect of losartan , an angiotensin_II antagonist , on hepatic_fibrosis induced by CCl4 in rats .
14504849	0	losartan	81,89	CYP2C9	21,27	losartan	CYP2C9	MESH:D019808	1559	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY allele|nmod|pharmacokinetics allele|nsubj|Effect Effect|nmod|END_ENTITY	Effect of the single CYP2C9 * 3 allele on pharmacokinetics and pharmacodynamics of losartan in healthy Japanese subjects .
19669737	0	losartan	49,57	CYP2C9	0,6	losartan	CYP2C9	MESH:D019808	1559	Chemical	Gene	START_ENTITY|nsubj|genotype genotype|amod|END_ENTITY	CYP2C9 genotype and pharmacodynamic responses to losartan in patients with primary and secondary kidney_diseases .
16297319	0	losartan	11,19	Janus_kinase_2	37,51	losartan	Janus kinase 2	MESH:D019808	24514(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of losartan on expression of Janus_kinase_2 and signal transducer and activator of transcription 3 in glomeruli of diabetic rats -RSB- .
25830624	0	losartan	11,19	MCP-1	73,78	losartan	MCP-1	MESH:D019808	24770(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of losartan on expression of monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- in hyperuricemic nephropathy rats .
8385523	0	losartan	25,33	Renin	0,5	losartan	Renin	MESH:D019808	24715(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|release release|compound|END_ENTITY	Renin release induced by losartan -LRB- DuP_753 -RRB- , an angiotensin_II receptor antagonist .
16221098	0	losartan	44,52	TGF-beta	0,8	losartan	TGF-beta	MESH:D019808	7040	Chemical	Gene	effects|nmod|START_ENTITY effects|amod|END_ENTITY	TGF-beta and TNF-alpha producing effects of losartan and amlodipine on human mononuclear cell culture .
18182718	0	losartan	11,19	TGF-beta1	42,51	losartan	TGF-beta1	MESH:D019808	59086(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expressions expressions|nmod|END_ENTITY	-LSB- Effect of losartan on the expressions of TGF-beta1 , p-Smad2 / 3 , and Smad7 in the remnant renal tissues of 5/6 nephrectomized rats -RSB- .
11702033	0	losartan	10,18	TNFalpha	34,42	losartan	TNFalpha	MESH:D019808	7124	Chemical	Gene	START_ENTITY|acl|circulating circulating|dobj|levels levels|compound|END_ENTITY	Effect of losartan on circulating TNFalpha levels and left ventricular systolic performance in patients with heart_failure .
17157123	0	losartan	14,22	adiponectin	47,58	losartan	adiponectin	MESH:D019808	9370	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of losartan and amlodipine on serum adiponectin in Japanese adults with essential_hypertension .
12545338	0	losartan	69,77	angiotensin-II_type_1_receptor	24,54	losartan	angiotensin-II type 1 receptor	MESH:D019808	185	Chemical	Gene	blockade|nmod|START_ENTITY blockade|amod|END_ENTITY	Two good reasons for an angiotensin-II_type_1_receptor blockade with losartan after cardiac transplantation : reduction of incidence and severity of transplant_vasculopathy .
10027087	0	losartan	13,21	angiotensin_II	111,125	losartan	angiotensin II	MESH:D019808	183	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of losartan and nicardipine on the contractile responses of human subcutaneous arteries and veins to angiotensin_II .
10067798	1	losartan	339,347	angiotensin_II	189,203	losartan	angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	using|dobj|START_ENTITY phase|acl|using characterize|nmod|phase characterize|dobj|receptors receptors|compound|END_ENTITY	OBJECTIVE : To characterize glomerular and preglomerular vascular angiotensin_II receptors during the acute phase of nonrenin-dependent one-kidney , one clip hypertension in rats , using the angiotensin_II antagonists losartan and PD_123319 , and to investigate their regulation after renin-angiotensin system blockade with either an angiotensin converting enzyme inhibitor , captopril , or an angiotensin_II receptor antagonist , TCV-116 .
10501344	0	losartan	41,49	angiotensin_II	15,29	losartan	angiotensin II	MESH:D019808	183	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|antagonist antagonist|amod|END_ENTITY	Effects of the angiotensin_II antagonist losartan on endothelin-1 and norepinephrine plasma levels during cold pressor test in patients with chronic_heart_failure .
10556495	0	losartan	60,68	angiotensin_II	16,30	losartan	angiotensin II	MESH:D019808	183	Chemical	Gene	AT|dobj|START_ENTITY AT|nsubj|Interactions Interactions|nmod|non-peptide non-peptide|amod|END_ENTITY	Interactions of angiotensin_II non-peptide AT -LRB- 1 -RRB- antagonist losartan with phospholipid membranes studied by combined use of differential scanning calorimetry and electron spin resonance spectroscopy .
10768859	0	losartan	70,78	angiotensin_II	22,36	losartan	angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Hypotensive effect of angiotensin_II after AT1-receptor blockade with losartan .
10826402	0	losartan	75,83	angiotensin_II	32,46	losartan	angiotensin II	MESH:D019808	183	Chemical	Gene	experience|nmod|START_ENTITY potential|dep|experience potential|nmod|antagonism antagonism|amod|END_ENTITY	The antiarrhythmic potential of angiotensin_II antagonism : experience with losartan .
11077868	0	losartan	135,143	angiotensin_II	108,122	losartan	angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	-RSB-|dep|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Experimental ischemic renal_injury -- effect of surgical technique and the protective effect of a nonpeptide angiotensin_II antagonist -LRB- losartan -RRB- -RSB- .
11118545	0	losartan	54,62	angiotensin_II	10,24	losartan	angiotensin II	MESH:D019808	183	Chemical	Gene	antagonist|dobj|START_ENTITY antagonist|nsubj|Effect Effect|nmod|AT AT|amod|END_ENTITY	Effect of angiotensin_II non-peptide AT -LRB- 1 -RRB- antagonist losartan on phosphatidylethanolamine membranes .
11435738	0	losartan	60,68	angiotensin_II	11,25	losartan	angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of angiotensin_II and the AT -LRB- 1 -RRB- receptor antagonist losartan on the renal excretion of urodilatin .
11743233	0	losartan	31,39	angiotensin_II	76,90	losartan	angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY dependent|nsubj|effects dependent|nmod|actions actions|nmod|END_ENTITY	Chronic hypotensive effects of losartan are not dependent on the actions of angiotensin_II at AT 2 receptors .
11744126	0	losartan	42,50	angiotensin_II	93,107	losartan	angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|apoptosis apoptosis|appos|END_ENTITY	Diverse effects of chronic treatment with losartan , fosinopril , and amlodipine on apoptosis , angiotensin_II in the left ventricle of hypertensive rats .
12013499	0	losartan	39,47	angiotensin_II	8,22	losartan	angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	antagonism|nmod|START_ENTITY antagonism|compound|END_ENTITY	Chronic angiotensin_II antagonism with losartan in one-kidney , one clip hypertensive rats : effect on cardiac_hypertrophy , urinary sodium and water excretion and the natriuretic system .
12397717	0	losartan	10,18	angiotensin_II	23,37	losartan	angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Effect of losartan , an angiotensin_II antagonist , on secondary biliary_cirrhosis .
1385640	0	losartan	11,19	angiotensin_II	34,48	losartan	angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Effects of losartan , a nonpeptide angiotensin_II receptor antagonist , on cardiac_hypertrophy and the tissue angiotensin_II content in spontaneously hypertensive rats .
1423014	0	losartan	122,130	angiotensin_II	47,61	losartan	angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	ligand|dobj|START_ENTITY ligand|nsubj|antagonism antagonism|nmod|responses responses|nmod|END_ENTITY	Competitive antagonism of pressor responses to angiotensin_II and angiotensin_III by the angiotensin_II-1 receptor ligand losartan .
1425998	0	losartan	15,23	angiotensin_II	42,56	losartan	angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	Enhancement|nmod|START_ENTITY Enhancement|acl|induced induced|dobj|antagonism antagonism|amod|END_ENTITY	Enhancement of losartan -LRB- DuP_753 -RRB- - induced angiotensin_II receptor antagonism by PD123177 in rats .
15046234	0	losartan	26,34	angiotensin_II	39,53	losartan	angiotensin II	MESH:D019808	183	Chemical	Gene	administration|nmod|START_ENTITY administration|appos|antagonist antagonist|amod|END_ENTITY	Chronic administration of losartan , an angiotensin_II receptor antagonist , is not effective in reducing portal pressure in patients with preascitic cirrhosis .
15573910	0	losartan	10,18	angiotensin_II	23,37	losartan	angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Effect of losartan , an angiotensin_II antagonist , on hepatic_fibrosis induced by CCl4 in rats .
1587065	0	losartan	92,100	angiotensin_II	105,119	losartan	angiotensin II	MESH:D019808	183	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Drug concentration response relationships in normal volunteers after oral administration of losartan , an angiotensin_II receptor antagonist .
15872078	0	losartan	161,169	angiotensin_II	135,149	losartan	angiotensin II	MESH:D019808	183	Chemical	Gene	study|compound|START_ENTITY study|amod|endpoints endpoints|nmod|NIDDM NIDDM|nmod|antagonist antagonist|amod|END_ENTITY	Importance of baseline distribution of proteinuria in renal outcomes trials : lessons from the reduction of endpoints in NIDDM with the angiotensin_II antagonist losartan -LRB- RENAAL -RRB- study .
1639114	0	losartan	76,84	angiotensin_II	40,54	losartan	angiotensin II	MESH:D019808	183	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Monoclonal antibodies to the nonpeptide angiotensin_II receptor antagonist , losartan .
17259110	0	losartan	12,20	angiotensin_II	38,52	losartan	angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|nmod|END_ENTITY	-LSB- Effects of losartan on the levels of angiotensin_II and its type-1 receptor in diabetic rat kidney -RSB- .
18800451	0	losartan	16,24	angiotensin_II	29,43	losartan	angiotensin II	MESH:D019808	183	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Pharmacology of losartan , an angiotensin_II receptor antagonist , in animal models of hypertension .
20621034	0	losartan	59,67	angiotensin_II	26,40	losartan	angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	effect|acl|START_ENTITY effect|nmod|blocker blocker|amod|END_ENTITY	The antioxidant effect of angiotensin_II receptor blocker , losartan , in streptozotocin-induced diabetic rats .
23876892	0	losartan	49,57	angiotensin_II	10,24	losartan	angiotensin II	MESH:D019808	183	Chemical	Gene	I|dobj|START_ENTITY I|nsubj|Effect Effect|nmod|type type|amod|END_ENTITY	Effect of angiotensin_II type I receptor blocker losartan on bone_deterioration in orchiectomized male hypertensive and normotensive rats .
24572913	0	losartan	26,34	angiotensin_II	105,119	losartan	angiotensin II	MESH:D019808	183	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|4A 4A|dep|antagonist antagonist|amod|END_ENTITY	Antithrombotic effects of losartan in patients with hypertension complicated by atrial_fibrillation : 4A -LRB- angiotensin_II antagonist of platelet_aggregation in patients with atrial_fibrillation -RRB- , a pilot study .
26763849	0	losartan	40,48	angiotensin_II	4,18	losartan	angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	The angiotensin_II receptor antagonist , losartan , enhances regulator of G protein signaling 2 mRNA expression in vascular smooth muscle cells of Wistar_rats .
7492986	0	losartan	11,19	angiotensin_II	24,38	losartan	angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Effects of losartan , an angiotensin_II antagonist , on the development of cardiac_hypertrophy due to volume_overload .
7702796	0	losartan	65,73	angiotensin_II	39,53	losartan	angiotensin II	MESH:D019808	183	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|antagonist antagonist|amod|END_ENTITY	Hemodynamic and humoral effects of the angiotensin_II antagonist losartan in essential hypertension .
7734113	0	losartan	18,26	angiotensin_II	53,67	losartan	angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY administration|dep|effect effect|nmod|content content|compound|END_ENTITY	Acute and chronic losartan administration : effect on angiotensin_II content and modulation of -LSB- 3H -RSB- norepinephrine release from rat interscapular brown adipose tissue .
7848024	0	losartan	63,71	angiotensin_II	30,44	losartan	angiotensin II	MESH:D019808	183	Chemical	Gene	blocker|appos|START_ENTITY blocker|amod|END_ENTITY	Blood pressure effects of the angiotensin_II receptor blocker , losartan .
7965263	0	losartan	70,78	angiotensin_II	44,58	losartan	angiotensin II	MESH:D019808	183	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|antagonist antagonist|amod|END_ENTITY	Hemodynamic and neurohumoral effects of the angiotensin_II antagonist losartan in patients with heart_failure .
7965264	0	losartan	41,49	angiotensin_II	15,29	losartan	angiotensin II	MESH:D019808	183	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|antagonist antagonist|amod|END_ENTITY	Effects of the angiotensin_II antagonist losartan in hypertensive patients with renal_disease .
7965799	0	losartan	15,23	angiotensin_II	36,50	losartan	angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	blockade|compound|START_ENTITY course|nmod|blockade course|nmod|hypertension hypertension|amod|END_ENTITY	Time course of losartan blockade of angiotensin_II hypertension versus blockade of angiotensin_II fast pressor effects .
7965799	0	losartan	15,23	angiotensin_II	83,97	losartan	angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	blockade|compound|START_ENTITY course|nmod|blockade course|nmod|effects effects|amod|END_ENTITY	Time course of losartan blockade of angiotensin_II hypertension versus blockade of angiotensin_II fast pressor effects .
8171048	0	losartan	12,20	angiotensin_II	119,133	losartan	angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|increase increase|nmod|hormone hormone|acl|produced produced|nmod|END_ENTITY	Intravenous losartan inhibits the increase in plasma luteinizing hormone and water intake produced by intraventricular angiotensin_II .
8315513	0	losartan	13,21	angiotensin_II	54,68	losartan	angiotensin II	MESH:D019808	183	Chemical	Gene	START_ENTITY|appos|receptor receptor|compound|END_ENTITY	Discovery of losartan , the first specific non-peptide angiotensin_II receptor antagonist .
8385523	0	losartan	25,33	angiotensin_II	48,62	losartan	angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Renin release induced by losartan -LRB- DuP_753 -RRB- , an angiotensin_II receptor antagonist .
8403307	0	losartan	71,79	angiotensin_II	45,59	losartan	angiotensin II	MESH:D019808	183	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|antagonist antagonist|amod|END_ENTITY	Hemodynamic and neurohormonal effects of the angiotensin_II antagonist losartan in patients with congestive_heart_failure .
8427658	0	losartan	22,30	angiotensin_II	45,59	losartan	angiotensin II	MESH:D019808	183	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Hypotensive effect of losartan , a nonpeptide angiotensin_II receptor antagonist , in essential hypertension .
8471405	0	losartan	91,99	angiotensin_II	129,143	losartan	angiotensin II	MESH:D019808	183	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Pharmacokinetics and biochemical efficacy after single and multiple oral administration of losartan , an orally active nonpeptide angiotensin_II receptor antagonist , in humans .
8510026	0	losartan	65,73	angiotensin_II	39,53	losartan	angiotensin II	MESH:D019808	183	Chemical	Gene	antagonist|dobj|START_ENTITY antagonist|nsubj|properties properties|nmod|END_ENTITY	Intrinsic properties of the nonpeptide angiotensin_II antagonist losartan in glomeruli and mesangial cells at high concentrations .
8558429	0	losartan	59,67	angiotensin_II	24,38	losartan	angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	antagonist|dobj|START_ENTITY antagonist|nsubj|Effects Effects|nmod|receptor receptor|compound|END_ENTITY	Effects of the specific angiotensin_II receptor antagonist losartan on urate homeostasis and intestinal urate transport .
8583479	0	losartan	13,21	angiotensin_II	33,47	losartan	angiotensin II	MESH:D019808	183	Chemical	Gene	START_ENTITY|appos|receptor receptor|compound|END_ENTITY	Discovery of losartan , the first angiotensin_II receptor antagonist .
8856477	0	losartan	75,83	angiotensin_II	11,25	losartan	angiotensin II	MESH:D019808	183	Chemical	Gene	comparison|nmod|START_ENTITY Effects|dep|comparison Effects|nmod|blockade blockade|amod|END_ENTITY	Effects of angiotensin_II receptor blockade during exercise : comparison of losartan and saralasin .
8869000	0	losartan	112,120	angiotensin_II	11,25	losartan	angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	binding|nmod|START_ENTITY angiotensin_II|amod|binding inhibition|nmod|angiotensin_II antagonists|nmod|inhibition antagonists|amod|END_ENTITY	Nonpeptide angiotensin_II receptor antagonists : in vivo inhibition of -LSB- 125I-Sar1 , Ile8 -RSB- angiotensin_II binding by losartan , EXP597 and L-159 ,282 in rats .
8869000	0	losartan	112,120	angiotensin_II	86,100	losartan	angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	binding|nmod|START_ENTITY END_ENTITY|amod|binding	Nonpeptide angiotensin_II receptor antagonists : in vivo inhibition of -LSB- 125I-Sar1 , Ile8 -RSB- angiotensin_II binding by losartan , EXP597 and L-159 ,282 in rats .
8876020	0	losartan	61,69	angiotensin_II	25,39	losartan	angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	antagonists|dobj|START_ENTITY antagonists|nsubj|Effects Effects|nmod|receptor receptor|compound|END_ENTITY	Effects of the selective angiotensin_II receptor antagonists losartan and PD123177 in animal models of anxiety and memory .
8944829	0	losartan	11,19	angiotensin_II	52,66	losartan	angiotensin II	MESH:D019808	183	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of losartan on vasoconstrictor responses to angiotensin_II in the forearm vascular bed of healthy volunteers .
8966199	0	losartan	129,137	angiotensin_II	11,25	losartan	angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	metabolite|nmod|START_ENTITY EXP3174|appos|metabolite rats|nmod|EXP3174 pharmacokinetics|nmod|rats antagonist|dep|pharmacokinetics antagonist|amod|END_ENTITY	Nonpeptide angiotensin_II receptor antagonist : pharmacokinetics and pharmacodynamics in rats of EXP3174 , an active metabolite of losartan .
8998251	0	losartan	53,61	angiotensin_II	15,29	losartan	angiotensin II	MESH:D019808	183	Chemical	Gene	blockade|nmod|START_ENTITY blockade|amod|END_ENTITY	The effects of angiotensin_II receptor blockade with losartan on systemic blood pressure and renal and extrarenal prostaglandin synthesis in women with essential hypertension .
9024174	0	losartan	89,97	angiotensin_II	12,26	losartan	angiotensin II	MESH:D019808	183	Chemical	Gene	administration|nmod|START_ENTITY DuP_532|dep|administration DuP_532|appos|antagonist antagonist|amod|END_ENTITY	DuP_532 , an angiotensin_II receptor antagonist : first administration and comparison with losartan .
9196266	0	losartan	89,97	angiotensin_II	61,75	losartan	angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	using|dobj|START_ENTITY rat|acl|using END_ENTITY|nmod|rat	Receptor subtypes mediating spinal cardiovascular effects of angiotensin_II in rat using losartan and PD_123319 .
9456277	0	losartan	72,80	angiotensin_II	20,34	losartan	angiotensin II	MESH:D019808	183	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|Venoconstriction Venoconstriction|nmod|END_ENTITY	Venoconstriction by angiotensin_II in the human forearm is inhibited by losartan but not by nicardipine .
9551878	0	losartan	134,142	angiotensin_II	88,102	losartan	angiotensin II	MESH:D019808	183	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|candesartan_cilexetil candesartan_cilexetil|appos|antagonist antagonist|compound|END_ENTITY	The antihypertensive effect and tolerability of candesartan_cilexetil , a new generation angiotensin_II antagonist , in comparison with losartan .
9723827	0	losartan	52,60	angiotensin_II	26,40	losartan	angiotensin II	MESH:D019808	183	Chemical	Gene	START_ENTITY|nsubj|Start Start|nmod|therapy therapy|nmod|antagonist antagonist|amod|END_ENTITY	Start of therapy with the angiotensin_II antagonist losartan after immediate switch from pretreatment with an ACE inhibitor .
9862248	0	losartan	79,87	angiotensin_II	11,25	losartan	angiotensin II	MESH:D019808	183	Chemical	Gene	study|nmod|START_ENTITY END_ENTITY|dep|study	Endogenous angiotensin_II and baroreceptor dysfunction : a comparative study of losartan and enalapril in man .
9886894	0	losartan	90,98	angiotensin_II	12,26	losartan	angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY AT2-subtype|nmod|effect AT2-subtype|nsubj|Role Role|nmod|END_ENTITY	Role of the angiotensin_II AT2-subtype receptors in the blood pressure-lowering effect of losartan in salt-restricted rats .
9918907	0	losartan	10,18	angiotensin_II	23,37	losartan	angiotensin II	MESH:D019808	183	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Effect of losartan , an angiotensin_II receptor antagonist , on portal pressure in cirrhosis .
14620386	0	losartan	60,68	angiotensin_II_subtype_1_receptor	15,48	losartan	angiotensin II subtype 1 receptor	MESH:D019808	24180(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|antagonist antagonist|amod|END_ENTITY	Effects of the angiotensin_II_subtype_1_receptor antagonist losartan on functional recovery of isolated rat hearts undergoing global myocardial_ischemia-reperfusion .
11082412	0	losartan	55,63	angiotensin_II_type_1-receptor	68,98	losartan	angiotensin II type 1-receptor	MESH:D019808	81638(Tax:10116)	Chemical	Gene	START_ENTITY|appos|blocker blocker|amod|END_ENTITY	Myocardial protection by preconditioning of heart with losartan , an angiotensin_II_type_1-receptor blocker : implication of bradykinin-dependent and bradykinin-independent mechanisms .
10697301	0	losartan	66,74	angiotensin_II_type_1_receptor	21,51	losartan	angiotensin II type 1 receptor	MESH:D019808	185	Chemical	Gene	blockade|nmod|START_ENTITY blockade|amod|END_ENTITY	Effects of selective angiotensin_II_type_1_receptor blockade with losartan on arterial compliance in patients with mild essential hypertension .
15040844	0	losartan	54,62	angiotensin_II_type_1_receptor	11,41	losartan	angiotensin II type 1 receptor	MESH:D019808	185	Chemical	Gene	Effects|appos|START_ENTITY Effects|nmod|antagonist antagonist|amod|END_ENTITY	Effects of angiotensin_II_type_1_receptor antagonist , losartan , on ventilatory response to exercise and neurohormonal profiles in patients with chronic_heart_failure .
15743363	0	losartan	92,100	angiotensin_II_type_1_receptor	7,37	losartan	angiotensin II type 1 receptor	MESH:D019808	185	Chemical	Gene	predict|advcl|START_ENTITY predict|nsubj|polymorphism polymorphism|amod|END_ENTITY	A1166C angiotensin_II_type_1_receptor gene polymorphism may predict hemodynamic response to losartan in patients with cirrhosis and portal_hypertension .
19907118	0	losartan	23,31	angiotensin_II_type_1_receptor	33,63	losartan	angiotensin II type 1 receptor	MESH:D019808	81638(Tax:10116)	Chemical	Gene	treatment|nmod|START_ENTITY treatment|appos|antagonist antagonist|amod|END_ENTITY	Chronic treatment with losartan -LRB- angiotensin_II_type_1_receptor antagonist -RRB- normalizes enhanced acetylcholine-induced coronary vasoconstriction in isolated perfused hearts of type 2 diabetic OLETF rats .
22292721	0	losartan	10,18	angiotensin_II_type_1_receptor	23,53	losartan	angiotensin II type 1 receptor	MESH:D019808	81638(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Effect of losartan , an angiotensin_II_type_1_receptor antagonist on cardiac autonomic functions of rats during acute and chronic inhibition of nitric_oxide synthesis .
23243146	0	losartan	24,32	angiotensin_II_type_1_receptor	52,82	losartan	angiotensin II type 1 receptor	MESH:D019808	81638(Tax:10116)	Chemical	Gene	infusion|compound|START_ENTITY modulates|nsubj|infusion modulates|dobj|expression expression|amod|END_ENTITY	Intracerebroventricular losartan infusion modulates angiotensin_II_type_1_receptor expression in the subfornical organ and drinking behaviour in bile-duct-ligated rats .
24717824	0	losartan	59,67	angiotensin_II_type_1_receptor	20,50	losartan	angiotensin II type 1 receptor	MESH:D019808	81638(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|blocker blocker|amod|END_ENTITY	Antitumor effect of angiotensin_II_type_1_receptor blocker losartan for orthotopic rat pancreatic adenocarcinoma .
26665236	0	losartan	70,78	angiotensin_II_type_1_receptor	18,48	losartan	angiotensin II type 1 receptor	MESH:D019808	185	Chemical	Gene	polymorphism|xcomp|START_ENTITY polymorphism|nsubj|importance importance|nmod|gene gene|amod|END_ENTITY	The importance of angiotensin_II_type_1_receptor gene polymorphism to losartan treatment in improving glomerulopathy in type 1 diabetic patients .
23106890	0	losartan	113,121	angiotensin_converting_enzyme	214,243	losartan	angiotensin converting enzyme	MESH:D019808	1636	Chemical	Gene	doses|nmod|START_ENTITY effects|nmod|doses evaluate|dobj|effects evaluate|nmod|intolerant intolerant|nmod|treatment treatment|amod|END_ENTITY	A multi-center , double-blind , randomized , parallel group study to evaluate the effects of two different doses of losartan on morbidity and mortality in Chinese patients with symptomatic heart_failure intolerant of angiotensin_converting_enzyme inhibitor treatment .
24552291	0	losartan	132,140	angiotensin_converting_enzyme	32,61	losartan	angiotensin converting enzyme	MESH:D019808	1636	Chemical	Gene	START_ENTITY|nsubj|design design|acl|combining combining|dobj|captopril captopril|amod|END_ENTITY	A novel design of combining the angiotensin_converting_enzyme -LRB- ACE -RRB- inhibitor captopril with the angiotensin receptor blocker -LRB- ARB -RRB- losartan using homo coupling via PEG diacid linker .
8984133	0	losartan	44,52	angiotensin_converting_enzyme	62,91	losartan	angiotensin converting enzyme	MESH:D019808	1636	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|amod|END_ENTITY	Comparison of the angiotensin_II antagonist losartan with the angiotensin_converting_enzyme inhibitor enalapril in patients with essential hypertension .
16321381	0	losartan	11,19	angiotensinogen	59,74	losartan	angiotensinogen	MESH:D019808	183	Chemical	Gene	administration|compound|START_ENTITY Effects|nmod|administration Effects|nmod|levels levels|compound|END_ENTITY	Effects of losartan and irbesartan administration on brain angiotensinogen mRNA levels .
20497421	0	losartan	47,55	biglycan	86,94	losartan	biglycan	MESH:D019808	633	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effects of the angiotensin II receptor blocker losartan on the monocyte expression of biglycan in hypertensive patients .
10411851	0	losartan	49,57	bradykinin	8,18	losartan	bradykinin	MESH:D019808	3827	Chemical	Gene	effects|nmod|START_ENTITY Role|nmod|effects Role|nmod|END_ENTITY	Role of bradykinin in the vasodilator effects of losartan and enalapril in patients with heart_failure .
15464217	0	losartan	109,117	c-fos	61,66	losartan	c-fos	MESH:D019808	2353	Chemical	Gene	associated|nmod|START_ENTITY associated|nmod|END_ENTITY	Induced fetal depressor or pressor responses associated with c-fos by intravenous or intracerebroventricular losartan .
18812657	0	losartan	10,18	cyclooxygenase-2	22,38	losartan	cyclooxygenase-2	MESH:D019808	5743	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of losartan on cyclooxygenase-2 expression in normal human mesangial cells and kidneys of rats with diabetic_nephropathy .
23635662	0	losartan	11,19	dimethylarginine_dimethylaminohydrolase-1	48,89	losartan	dimethylarginine dimethylaminohydrolase-1	MESH:D019808	64157(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|amod|END_ENTITY	Effects of losartan and pentoxifylline on renal dimethylarginine_dimethylaminohydrolase-1 expression in proteinuric_nephropathy .
22519909	0	losartan	121,129	dipeptidyl_peptidase-IV	26,49	losartan	dipeptidyl peptidase-IV	MESH:D019808	1803	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Combined treatment with a dipeptidyl_peptidase-IV inhibitor -LRB- sitagliptin -RRB- and an angiotensin_II_type_1_receptor blocker -LRB- losartan -RRB- promotes islet regeneration via enhanced differentiation of pancreatic progenitor cells .
10501344	0	losartan	41,49	endothelin-1	53,65	losartan	endothelin-1	MESH:D019808	1906	Chemical	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	Effects of the angiotensin_II antagonist losartan on endothelin-1 and norepinephrine plasma levels during cold pressor test in patients with chronic_heart_failure .
9715793	0	losartan	11,19	endothelin-1	37,49	losartan	endothelin-1	MESH:D019808	24323(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|production production|amod|END_ENTITY	Effects of losartan and captopril on endothelin-1 production in blood vessels and glomeruli of rats with reduced renal mass .
11124620	0	losartan	13,21	erythropoietin	37,51	losartan	erythropoietin	MESH:D019808	2056	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|therapy therapy|compound|END_ENTITY	No effect of losartan on response to erythropoietin therapy in patients undergoing hemodialysis .
11877580	0	losartan	11,19	erythropoietin	60,74	losartan	erythropoietin	MESH:D019808	2056	Chemical	Gene	Effects|nmod|START_ENTITY circulating|nsubj|Effects circulating|dobj|END_ENTITY	Effects of losartan or enalapril on hemoglobin , circulating erythropoietin , and insulin-like_growth_factor-1 in patients with and without posttransplant erythrocytosis .
12682621	0	losartan	24,32	erythropoietin	36,50	losartan	erythropoietin	MESH:D019808	2056	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	The effect of high dose losartan on erythropoietin resistance in patients undergoing haemodialysis .
11236238	0	losartan	47,55	insulin	69,76	losartan	insulin	MESH:D019808	3630	Chemical	Gene	START_ENTITY|nmod|levels levels|nmod|resistance resistance|compound|END_ENTITY	-LSB- The effect of treatment with enalapril versus losartan on levels of insulin resistance in patients with essential_hypertension -RSB- .
20827028	0	losartan	12,20	insulin	74,81	losartan	insulin	MESH:D019808	3630	Chemical	Gene	Addition|nmod|START_ENTITY improves|nsubj|Addition improves|dobj|resistance resistance|compound|END_ENTITY	Addition of losartan to angiotensin-converting enzyme inhibitors improves insulin resistance in patients with chronic_heart_failure treated without b-blockers .
26763851	0	losartan	34,42	insulin	73,80	losartan	insulin	MESH:D019808	3630	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	Effects of antihypertensive drugs losartan and levamlodipine_besylate on insulin resistance in patients with essential hypertension combined with isolated impaired_fasting_glucose .
11862111	0	losartan	94,102	matrix_metalloproteinase-1	14,40	losartan	matrix metalloproteinase-1	MESH:D019808	100009110(Tax:9986)	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|END_ENTITY	Modulation of matrix_metalloproteinase-1 , its tissue inhibitor , and nuclear factor-kappa B by losartan in hypercholesterolemic rabbits .
21868333	0	losartan	11,19	monocyte_chemoattractant_protein-1	43,77	losartan	monocyte chemoattractant protein-1	MESH:D019808	24770(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|acl|END_ENTITY	-LSB- Effect of losartan on renal expression of monocyte_chemoattractant_protein-1 and transforming_growth_factor-b -LRB- 1 -RRB- in rats after unilateral ureteral obstruction -RSB- .
25830624	0	losartan	11,19	monocyte_chemoattractant_protein-1	37,71	losartan	monocyte chemoattractant protein-1	MESH:D019808	24770(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effects of losartan on expression of monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- in hyperuricemic nephropathy rats .
16365190	0	losartan	75,83	peroxisome_proliferator-activated_receptor_gamma	14,62	losartan	peroxisome proliferator-activated receptor gamma	MESH:D019808	5468	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Regulation of peroxisome_proliferator-activated_receptor_gamma activity by losartan metabolites .
16714774	0	losartan	29,37	renin	53,58	losartan	renin	MESH:D019808	24715(Tax:10116)	Chemical	Gene	receptors|nmod|START_ENTITY Blockade|nmod|receptors affect|nsubj|Blockade affect|dobj|expression expression|compound|END_ENTITY	Blockade of AT1 receptors by losartan did not affect renin gene expression in kidney medulla .
7699984	0	losartan	19,27	renin	38,43	losartan	renin	MESH:D019808	443310(Tax:9940)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of central losartan on plasma renin and centrally mediated natriuresis .
8554732	0	losartan	28,36	renin	68,73	losartan	renin	MESH:D019808	5972	Chemical	Gene	therapy|compound|START_ENTITY therapy|nmod|renin renin|amod|END_ENTITY	Effect of acute and chronic losartan therapy on active and inactive renin and active renin glycoforms .
8554732	0	losartan	28,36	renin	85,90	losartan	renin	MESH:D019808	5972	Chemical	Gene	therapy|compound|START_ENTITY therapy|nmod|END_ENTITY	Effect of acute and chronic losartan therapy on active and inactive renin and active renin glycoforms .
8899890	0	losartan	23,31	renin	65,70	losartan	renin	MESH:D019808	443310(Tax:9940)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|reduction reduction|nmod|concentration concentration|compound|END_ENTITY	Centrally administered losartan inhibits the reduction in plasma renin concentration caused by intracerebroventricular hypertonic saline in Na-depleted sheep .
9927293	3	losartan	888,896	renin	1009,1014	losartan	renin	MESH:D019808	24715(Tax:10116)	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nmod|absence absence|acl|circulating circulating|dobj|END_ENTITY	Moreover , the rise of aldosterone levels was also inhibited by the AT1-receptor antagonist , losartan -LRB- 10 microg/kg x min , chronically i.p. from 8 + / - 2 to 199 + / - 26 ng/100 ml -RRB- , despite the absence of circulating renin and a reduction of ANG I to less than 10 % .
26806573	0	losartan	76,84	salvianolic_acid_B	11,29	losartan	salvianolic acid B	MESH:D019808	117186(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of salvianolic_acid_B and tanshinone_IIA on the pharmacokinetics of losartan in rats by regulating the activities and eXPRESsION OF cyp3a4 AND cyp2c9 .
15637465	0	losartan	32,40	transforming_growth_factor-beta1	52,84	losartan	transforming growth factor-beta1	MESH:D019808	59086(Tax:10116)	Chemical	Gene	angiotensin_II|nmod|START_ENTITY Blockade|nmod|angiotensin_II attenuates|nsubj|Blockade attenuates|dobj|expression expression|amod|END_ENTITY	Blockade of angiotensin_II with losartan attenuates transforming_growth_factor-beta1 inducible gene-h3 -LRB- betaig-h3 -RRB- expression in a model of chronic cyclosporine nephrotoxicity .
19304546	0	losartan	12,20	transforming_growth_factor-beta1	64,96	losartan	transforming growth factor-beta1	MESH:D019808	7040	Chemical	Gene	Effects|nmod|START_ENTITY Effects|amod|END_ENTITY	-LSB- Effects of losartan on left_ventricular_hypertrophy and plasma transforming_growth_factor-beta1 in elderly patients with hypertension -RSB- .
10903217	0	losartan	10,18	type_1_angiotensin_II_receptor	22,52	losartan	type 1 angiotensin II receptor	MESH:D019808	185	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|antagonist antagonist|amod|END_ENTITY	Effect of losartan , a type_1_angiotensin_II_receptor antagonist , on bronchial_hyperresponsiveness to methacholine in patients with bronchial_asthma .
18670416	0	losartan	21,29	urate_transporter_1	52,71	losartan	urate transporter 1	MESH:D019808	116085	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Uricosuric action of losartan via the inhibition of urate_transporter_1 -LRB- URAT_1 -RRB- in hypertensive patients .
16677737	0	losartan	18,26	vasopressin	58,69	losartan	vasopressin	MESH:D019808	551	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	Effects of i.c.v. losartan on the angiotensin_II-mediated vasopressin release and hypothalamic fos expression in near-term ovine fetuses .
1472262	0	losartan_potassium	10,28	angiotensin_II	122,136	losartan potassium	angiotensin II	MESH:D019808	24179(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of losartan_potassium and deoxycorticosterone_acetate on tail skin temperature response to acute administration of angiotensin_II .
23239139	0	losmapimod	69,79	p38	43,46	losmapimod	p38	MESH:C543534	1432	Chemical	Gene	inhibitor|acl|START_ENTITY inhibitor|amod|END_ENTITY	Analgesic efficacy and safety of the novel p38 MAP kinase inhibitor , losmapimod , in patients with neuropathic_pain following peripheral_nerve_injury : a double-blind , placebo-controlled study .
24699061	0	losmapimod	72,82	p38	47,50	losmapimod	p38	MESH:C543534	1432	Chemical	Gene	START_ENTITY|nsubj|Evaluation Evaluation|nmod|properties properties|nmod|inhibitor inhibitor|amod|END_ENTITY	Evaluation of antidepressant properties of the p38 MAP kinase inhibitor losmapimod -LRB- GW856553 -RRB- in Major_Depressive_Disorder : Results from two randomised , placebo-controlled , double-blind , multicentre studies using a Bayesian approach .
14988223	0	lovastatin	94,104	E-selectin	27,37	lovastatin	E-selectin	MESH:D008148	6401	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|csubjpass|Ionizing Ionizing|dobj|expression expression|amod|END_ENTITY	Ionizing radiation-induced E-selectin gene expression and tumor cell adhesion is inhibited by lovastatin and all-trans_retinoic_acid .
8709977	0	lovastatin	66,76	GTP-binding_protein	23,42	lovastatin	GTP-binding protein	MESH:D008148	8843	Chemical	Gene	increased|nmod|START_ENTITY increased|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of a 24 kDa GTP-binding_protein -LRB- Gn24 -RRB- is increased in lovastatin treated human erythroleukemia cells .
9018116	0	lovastatin	28,38	H-Ras	63,68	lovastatin	H-Ras	MESH:D008148	3265	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	Geranylgeraniol potentiates lovastatin inhibition of oncogenic H-Ras processing and signaling while preventing cytotoxicity .
1412144	1	lovastatin	62,72	HMG-CoA_reductase	32,49	lovastatin	HMG-CoA reductase	MESH:D008148	3156	Chemical	Gene	-RSB-|compound|START_ENTITY inhibitors|dep|-RSB- inhibitors|amod|END_ENTITY	HMG-CoA_reductase inhibitors : lovastatin and simvastatin -RSB- .
19896074	0	lovastatin	31,41	LFA-1	9,14	lovastatin	LFA-1	MESH:D008148	16408(Tax:10090)	Chemical	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Blocking LFA-1 activation with lovastatin prevents graft-versus-host_disease in mouse bone marrow transplantation .
25738322	0	lovastatin	32,42	MCM2	0,4	lovastatin	MCM2	MESH:D008148	4171	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	MCM2 is a therapeutic target of lovastatin in human non-small_cell_lung_carcinomas .
19898809	0	lovastatin	11,21	P-glycoprotein	125,139	lovastatin	P-glycoprotein	MESH:D008148	287115(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|dep|role role|nmod|inhibition inhibition|amod|END_ENTITY	Effects of lovastatin on the pharmacokinetics of verapamil and its active metabolite , norverapamil in rats : possible role of P-glycoprotein inhibition by lovastatin .
19898809	0	lovastatin	154,164	P-glycoprotein	125,139	lovastatin	P-glycoprotein	MESH:D008148	287115(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Effects of lovastatin on the pharmacokinetics of verapamil and its active metabolite , norverapamil in rats : possible role of P-glycoprotein inhibition by lovastatin .
20012601	0	lovastatin	124,134	P-glycoprotein	95,109	lovastatin	P-glycoprotein	MESH:D008148	5243	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Pharmacokinetic interaction between oral lovastatin and verapamil in healthy subjects : role of P-glycoprotein inhibition by lovastatin .
20012601	0	lovastatin	41,51	P-glycoprotein	95,109	lovastatin	P-glycoprotein	MESH:D008148	5243	Chemical	Gene	interaction|nmod|START_ENTITY interaction|dep|role role|nmod|inhibition inhibition|amod|END_ENTITY	Pharmacokinetic interaction between oral lovastatin and verapamil in healthy subjects : role of P-glycoprotein inhibition by lovastatin .
21189658	0	lovastatin	183,193	P-glycoprotein	154,168	lovastatin	P-glycoprotein	MESH:D008148	287115(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Effects of lovastatin on the pharmacokinetics of diltiazem and its main metabolite , desacetyldiltiazem , in rats : possible role of cytochrome P450 3A4 and P-glycoprotein inhibition by lovastatin .
20721249	0	lovastatin	41,51	PC3	71,74	lovastatin	PC3	MESH:D008148	57332	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	-LSB- Effects of clinically effective dose of lovastatin on prostate_cancer PC3 cells -RSB- .
21833028	0	lovastatin	32,42	Rac1	14,18	lovastatin	Rac1	MESH:D008148	19353(Tax:10090)	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Inhibition of Rac1 signaling by lovastatin protects against anthracycline-induced cardiac_toxicity .
25835225	0	lovastatin	18,28	SC0156	77,83	lovastatin	SC0156	MESH:D008148	3332568(Tax:321314)	Chemical	Gene	analogue|compound|START_ENTITY analogue|nmod|END_ENTITY	Versicorin , a new lovastatin analogue from the fungus Aspergillus versicolor SC0156 .
1940775	0	lovastatin	97,107	apolipoprotein_B	65,81	lovastatin	apolipoprotein B	MESH:D008148	338	Chemical	Gene	treatment|compound|START_ENTITY response|nmod|treatment END_ENTITY|nmod|response	Effect of apolipoprotein_E polymorphism and XbaI polymorphism of apolipoprotein_B on response to lovastatin treatment in familial and non-familial_hypercholesterolaemia .
3680522	0	lovastatin	102,112	apolipoprotein_B	15,31	lovastatin	apolipoprotein B	MESH:D008148	338	Chemical	Gene	Suppression|nmod|START_ENTITY Suppression|nmod|production production|amod|END_ENTITY	Suppression of apolipoprotein_B production during treatment of cholesteryl_ester_storage_disease with lovastatin .
8487493	0	lovastatin	14,24	apolipoprotein_B	57,73	lovastatin	apolipoprotein B	MESH:D008148	338	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|production production|compound|END_ENTITY	The effect of lovastatin on very low-density lipoprotein apolipoprotein_B production by the liver in familial_combined_hyperlipidaemia .
19787257	0	lovastatin	23,33	caveolin-1	51,61	lovastatin	caveolin-1	MESH:D008148	857	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Synergistic effects of lovastatin and celecoxib on caveolin-1 and its down-stream signaling molecules : Implications for colon_cancer prevention .
24634114	0	lovastatin	11,21	low-density_lipoprotein_receptor	51,83	lovastatin	low-density lipoprotein receptor	MESH:D008148	300438(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of lovastatin on hepatic expression of the low-density_lipoprotein_receptor in nephrotic rats .
9072409	0	lovastatin	10,20	phosphatidylinositol_3-kinase	45,74	lovastatin	phosphatidylinositol 3-kinase	MESH:D008148	5293	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effect of lovastatin and fluoromevalonate on phosphatidylinositol_3-kinase activity stimulated with PDGF .
19419936	0	lovastatin	17,27	thrombomodulin	31,45	lovastatin	thrombomodulin	MESH:D008148	7056	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	The influence of lovastatin on thrombomodulin gene expression in vascular endothelial cells -- in vitro study .
1996640	0	loxiglumide	96,107	CCK	8,11	loxiglumide	CCK	null	885	Chemical	Gene	effects|nmod|START_ENTITY Role|dep|effects Role|nmod|END_ENTITY	Role of CCK in regulation of pancreaticobiliary functions and GI motility in humans : effects of loxiglumide .
2295294	0	loxiglumide	23,34	CCK	36,39	loxiglumide	CCK	null	885	Chemical	Gene	administration|nmod|START_ENTITY administration|appos|antagonist antagonist|compound|END_ENTITY	Oral administration of loxiglumide -LRB- CCK antagonist -RRB- inhibits postprandial gallbladder contraction without affecting gastric emptying .
9368707	0	loxiglumide	43,54	Cholecystokinin	0,15	loxiglumide	Cholecystokinin	null	12424(Tax:10090)	Chemical	Gene	activities|nmod|START_ENTITY activities|amod|END_ENTITY	Cholecystokinin antagonistic activities of loxiglumide .
1291406	0	loxiglumide	108,119	cholecystokinin	132,147	loxiglumide	cholecystokinin	null	885	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Role of endogenously released cholecystokinin in determining postprandial insulin levels in man : effects of loxiglumide , a specific cholecystokinin receptor antagonist .
1291406	0	loxiglumide	108,119	cholecystokinin	30,45	loxiglumide	cholecystokinin	null	885	Chemical	Gene	effects|nmod|START_ENTITY Role|dep|effects Role|nmod|END_ENTITY	Role of endogenously released cholecystokinin in determining postprandial insulin levels in man : effects of loxiglumide , a specific cholecystokinin receptor antagonist .
1607730	0	loxiglumide	53,64	cholecystokinin	26,41	loxiglumide	cholecystokinin	null	25298(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|antagonist antagonist|compound|END_ENTITY	Inhibitory effects of the cholecystokinin antagonist loxiglumide on pancreatic exocrine secretion and pancreatic growth in conscious rats .
2227288	0	loxiglumide	10,21	cholecystokinin	25,40	loxiglumide	cholecystokinin	null	885	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Effect of loxiglumide , a cholecystokinin antagonist , on pancreatic polypeptide release in humans .
2344859	0	loxiglumide	10,21	cholecystokinin	72,87	loxiglumide	cholecystokinin	null	885	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of loxiglumide -LRB- CR-1505 -RRB- on bombesin - and meal-stimulated plasma cholecystokinin in man .
8386784	0	loxiglumide	52,63	cholecystokinin	24,39	loxiglumide	cholecystokinin	null	885	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	Inhibitory effects of a cholecystokinin antagonist , loxiglumide -LRB- CR-1505 -RRB- , on the growth of freshly separated and xenografted human pancreatic_cancer .
9391249	0	loxiglumide	133,144	cholecystokinin	8,23	loxiglumide	cholecystokinin	null	885	Chemical	Gene	studies|nmod|START_ENTITY Role|dep|studies Role|nmod|END_ENTITY	Role of cholecystokinin in the regulation of liquid gastric emptying and gastric motility in humans : studies with the CCK antagonist loxiglumide .
12131781	0	loxiglumide	87,98	cholecystokinin-A_receptor	48,74	loxiglumide	cholecystokinin-A receptor	null	886	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Clinical evaluation of oral administration of a cholecystokinin-A_receptor antagonist -LRB- loxiglumide -RRB- to patients with acute , painful attacks of chronic pancreatitis : a multicenter dose-response study in Japan .
24261771	0	loxoprofen	111,121	cyclooxygenase-2	60,76	loxoprofen	cyclooxygenase-2	MESH:C040656	5743	Chemical	Gene	celecoxib|nmod|START_ENTITY celecoxib|amod|END_ENTITY	Comparative study of the clinical efficacy of the selective cyclooxygenase-2 inhibitor celecoxib compared with loxoprofen in patients with frozen shoulder .
27043269	0	lubeluzole	27,37	calmodulin	44,54	lubeluzole	calmodulin	MESH:C097722	808	Chemical	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	The chemosensitizing agent lubeluzole binds calmodulin and inhibits Ca -LRB- 2 + -RRB- / calmodulin-dependent_kinase_II .
23316067	0	lubiprostone	37,49	CFTR	19,23	lubiprostone	CFTR	MESH:C506401	12638(Tax:10090)	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Dual activation of CFTR and CLCN2 by lubiprostone in murine nasal epithelia .
21769655	0	lubiprostone	38,50	chloride_channel	54,70	lubiprostone	chloride channel	MESH:C506401	1181	Chemical	Gene	START_ENTITY|appos|activator activator|amod|END_ENTITY	Long-term safety and effectiveness of lubiprostone , a chloride_channel -LRB- ClC-2 -RRB- activator , in patients with chronic_idiopathic_constipation .
6230077	0	luliberin	91,100	luteinizing-hormone-releasing_hormone	52,89	luliberin	luteinizing-hormone-releasing hormone	MESH:D007987	25194(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Stimulation of cholesterol side-chain cleavage by a luteinizing-hormone-releasing_hormone -LRB- luliberin -RRB- agonist -LRB- ICI_118630 -RRB- in rat Leydig cells .
15177307	0	lumiracoxib	71,82	COX-2	92,97	lumiracoxib	COX-2	MESH:C473384	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|selective selective|amod|END_ENTITY	No influence of moderate hepatic_impairment on the pharmacokinetics of lumiracoxib , an oral COX-2 selective inhibitor .
18092115	0	lumiracoxib	51,62	COX-2	76,81	lumiracoxib	COX-2	MESH:C473384	4513	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	A case of takotsubo_cardiomyopathy precipitated by lumiracoxib , a selective COX-2 inhibitor .
23984829	0	lumiracoxib	43,54	COX-2	16,21	lumiracoxib	COX-2	MESH:C473384	4513	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|selective selective|amod|END_ENTITY	Drug analogs of COX-2 selective inhibitors lumiracoxib and valdecoxib derived from in silico search and optimization .
16372823	0	lumiracoxib	25,36	cyclo-oxygenase-2	50,67	lumiracoxib	cyclo-oxygenase-2	MESH:C473384	5743	Chemical	Gene	pharmacology|nmod|START_ENTITY pharmacology|dep|inhibitor inhibitor|amod|END_ENTITY	Clinical pharmacology of lumiracoxib : a selective cyclo-oxygenase-2 inhibitor .
15655513	0	lumiracoxib	28,39	cyclooxygenase-2	72,88	lumiracoxib	cyclooxygenase-2	MESH:C473384	5743	Chemical	Gene	pharmacology|nmod|START_ENTITY pharmacology|dep|inhibitor inhibitor|nmod|END_ENTITY	Preclinical pharmacology of lumiracoxib : a novel selective inhibitor of cyclooxygenase-2 .
17434872	0	lumiracoxib	75,86	cyclooxygenase-2	55,71	lumiracoxib	cyclooxygenase-2	MESH:C473384	5743	Chemical	Gene	determinants|nmod|START_ENTITY determinants|nmod|inhibition inhibition|nmod|END_ENTITY	Molecular determinants for the selective inhibition of cyclooxygenase-2 by lumiracoxib .
19875043	0	lumiracoxib	45,56	cyclooxygenase-2	87,103	lumiracoxib	cyclooxygenase-2	MESH:C473384	29527(Tax:10116)	Chemical	Gene	derivative|compound|START_ENTITY Synthesis|nmod|derivative Synthesis|nmod|imaging imaging|nmod|expression expression|amod|END_ENTITY	Synthesis and evaluation of a radioiodinated lumiracoxib derivative for the imaging of cyclooxygenase-2 expression .
19958362	0	lumiracoxib	70,81	cyclooxygenase-2	108,124	lumiracoxib	cyclooxygenase-2	MESH:C473384	29527(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY modelling|nmod|effects modelling|appos|inhibitor inhibitor|nmod|END_ENTITY	Pharmacokinetic-pharmacodynamic modelling of the analgesic effects of lumiracoxib , a selective inhibitor of cyclooxygenase-2 , in rats .
24060487	0	lumiracoxib	94,105	cyclooxygenase-2	74,90	lumiracoxib	cyclooxygenase-2	MESH:C473384	5743	Chemical	Gene	Exploring|nmod|START_ENTITY Exploring|dobj|determinants determinants|nmod|inhibition inhibition|nmod|END_ENTITY	Exploring the molecular determinants of substrate-selective inhibition of cyclooxygenase-2 by lumiracoxib .
24469906	0	lumiracoxib	76,87	cyclooxygenase-2	39,55	lumiracoxib	cyclooxygenase-2	MESH:C473384	5743	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Similar maximum systemic but not local cyclooxygenase-2 inhibition by 50 mg lumiracoxib and 90 mg etoricoxib : a randomized controlled trial in healthy subjects .
15882125	0	lumiracoxib	25,36	cyclooxygenase_2	58,74	lumiracoxib	cyclooxygenase 2	MESH:C473384	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Clinical pharmacology of lumiracoxib , a second-generation cyclooxygenase_2 selective inhibitor .
26004524	0	lupeol	72,78	Brain-Derived_Neurotrophic_Factor	83,116	lupeol	Brain-Derived Neurotrophic Factor	MESH:C010480	627	Chemical	Gene	START_ENTITY|nmod|Inhibition Inhibition|compound|END_ENTITY	A novel mechanism of hepatocellular_carcinoma cell apoptosis induced by lupeol via Brain-Derived_Neurotrophic_Factor Inhibition and Glycogen_Synthase_Kinase_3_beta reactivation .
26959552	0	lupeol	68,74	cytochrome_P450	14,29	lupeol	cytochrome P450	MESH:C010480	25251(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Assessment of cytochrome_P450 inhibition and induction potential of lupeol and betulin in rat liver microsomes .
11768533	0	lupine	7,13	cyclophilin	14,25	lupine	cyclophilin	null	9360	Chemical	Gene	transcripts|amod|START_ENTITY transcripts|compound|END_ENTITY	Yellow lupine cyclophilin transcripts are highly accumulated in the nodule meristem zone .
23492941	0	luseogliflozin	34,48	SGLT2	17,22	luseogliflozin	SGLT2	null	64522(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Effects of a new SGLT2 inhibitor , luseogliflozin , on diabetic_nephropathy in T2DN rats .
26354015	0	luseogliflozin	63,77	SGLT2	46,51	luseogliflozin	SGLT2	null	6524	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Pharmacological and clinical profile of a new SGLT2 inhibitor , luseogliflozin -LRB- Lusefi -LRB- -RRB- -RRB- .
26505796	0	luseogliflozin	38,52	SGLT2	22,27	luseogliflozin	SGLT2	null	246787(Tax:10090)	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|effects effects|nmod|END_ENTITY	Protective effects of SGLT2 inhibitor luseogliflozin on pancreatic b-cells in obese_type_2 diabetic db/db mice .
24475153	0	lutein	60,66	Cameo2	19,25	lutein	Cameo2	MESH:D014975	100328605(Tax:7091)	Chemical	Gene	uptake|nmod|START_ENTITY effect|nmod|uptake effect|nmod|END_ENTITY	Combined effect of Cameo2 and CBP on the cellular uptake of lutein in the silkworm , Bombyx_mori .
26519703	0	lutein	44,50	MB-1	88,92	lutein	MB-1	MESH:D014975	973	Chemical	Gene	Production|nmod|START_ENTITY Production|nmod|END_ENTITY	Production , extraction and stabilization of lutein from microalga Chlorella sorokiniana MB-1 .
17340577	0	lutein	8,14	inducible_nitric_oxide_synthase	25,56	lutein	inducible nitric oxide synthase	MESH:D014975	18126(Tax:10090)	Chemical	Gene	modulates|compound|START_ENTITY END_ENTITY|nsubj|modulates	Dietary lutein modulates inducible_nitric_oxide_synthase -LRB- iNOS -RRB- gene and protein expression in mouse macrophage cells -LRB- RAW 264.7 -RRB- .
16631350	0	lutein	43,49	nNOS	14,18	lutein	nNOS	MESH:D014975	24598(Tax:10116)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of nNOS and COX-2 expression by lutein in acute retinal_ischemia .
24129732	0	luteolin	22,30	AEG-1	143,148	luteolin	AEG-1	MESH:D047311	92140	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Inhibitory effect of luteolin on the angiogenesis of chick chorioallantoic membrane and invasion of breast_cancer cells via downregulation of AEG-1 and MMP-2 -RSB- .
18300499	0	luteolin	11,19	COX-2	23,28	luteolin	COX-2	MESH:D047311	17709(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effect of luteolin on COX-2 and mPGES-1 expression in LPS-induced RAW264 .7 cells -RSB- .
20971650	0	luteolin	33,41	DAT	57,60	luteolin	DAT	MESH:D047311	24898(Tax:10116)	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	Discovery and synthesis of novel luteolin derivatives as DAT agonists .
15589482	0	luteolin	21,29	IL-8	51,55	luteolin	IL-8	MESH:D047311	3576	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|production production|compound|END_ENTITY	Inhibitory effect of luteolin on TNF-alpha-induced IL-8 production in human colon epithelial cells .
19739098	0	luteolin	68,76	NF-kappaB	44,53	luteolin	NF-kappaB	MESH:D047311	4790	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Attenuating Smac mimetic compound 3-induced NF-kappaB activation by luteolin leads to synergistic cytotoxicity in cancer cells .
24481824	0	luteolin	21,29	Nrf2	148,152	luteolin	Nrf2	MESH:D047311	4780	Chemical	Gene	effect|nmod|START_ENTITY smoke|nsubj|effect smoke|nmod|cells cells|nmod|pathway pathway|amod|END_ENTITY	Protective effect of luteolin on cigarette smoke extract-induced cellular toxicity and apoptosis in normal human bronchial epithelial cells via the Nrf2 pathway .
24481824	8	luteolin	1257,1265	Nrf2	1369,1373	luteolin	Nrf2	MESH:D047311	4780	Chemical	Gene	attenuated|nsubj|START_ENTITY attenuated|dobj|apoptosis apoptosis|appos|expression expression|nmod|NF-E2-related_factor_2 NF-E2-related_factor_2|appos|END_ENTITY	Furthermore , luteolin attenuated CSE-induced apoptosis , noticeably reduced CSE-induced expression of NF-E2-related_factor_2 -LRB- Nrf2 -RRB- , NQO1 and HO-1 using a small interfering RNA -LRB- siRNA -RRB- transfection assay .
22696246	0	luteolin	21,29	SOD1	75,79	luteolin	SOD1	MESH:D047311	24786(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|END_ENTITY	Protective effect of luteolin in experimental ischemic stroke : upregulated SOD1 , CAT , Bcl-2 and claudin-5 , down-regulated MDA and Bax expression .
19739098	0	luteolin	68,76	Smac	12,16	luteolin	Smac	MESH:D047311	56616	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Attenuating Smac mimetic compound 3-induced NF-kappaB activation by luteolin leads to synergistic cytotoxicity in cancer cells .
18008333	0	luteolin	50,58	androgen_receptor	18,35	luteolin	androgen receptor	MESH:D047311	367	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Downregulation of androgen_receptor expression by luteolin causes inhibition of cell proliferation and induction of apoptosis in human prostate_cancer cells and xenografts .
24726243	0	luteolin	43,51	angiotensin_II	97,111	luteolin	angiotensin II	MESH:D047311	11606(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY stimulated|nsubj|effects stimulated|nmod|END_ENTITY	Anti-oxidant and anti-apoptotic effects of luteolin on mice peritoneal macrophages stimulated by angiotensin_II .
25409926	0	luteolin	20,28	cyclooxygenase-2	55,71	luteolin	cyclooxygenase-2	MESH:D047311	5743	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|amod|END_ENTITY	Biphasic effects of luteolin on interleukin-1b-induced cyclooxygenase-2 expression in glioblastoma cells .
16458870	0	luteolin	21,29	hepatocyte_growth_factor	33,57	luteolin	hepatocyte growth factor	MESH:D047311	3082	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Inhibitory effect of luteolin on hepatocyte_growth_factor / scatter factor-induced HepG2 cell invasion involving both MAPK/ERKs and PI3K-Akt pathways .
23782102	0	luteolin	86,94	interleukin-8	49,62	luteolin	interleukin-8	MESH:D047311	3576	Chemical	Gene	inhibited|nmod|START_ENTITY END_ENTITY|acl:relcl|inhibited	Stimulated human melanocytes express and release interleukin-8 , which is inhibited by luteolin : relevance to early vitiligo .
3289536	0	lutropin	83,91	gonadotropin-releasing_hormone	28,58	lutropin	gonadotropin-releasing hormone	MESH:D007986	25194(Tax:10116)	Chemical	Gene	synthesis|nmod|START_ENTITY synthesis|amod|END_ENTITY	Detection of a lag phase in gonadotropin-releasing_hormone stimulated synthesis of lutropin peptide chains in cultured rat anterior pituitary cells .
21462325	0	lycopene	20,28	CD36	0,4	lycopene	CD36	MESH:C015329	12491(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY involved|nmod|uptake involved|nsubjpass|END_ENTITY	CD36 is involved in lycopene and lutein uptake by adipocytes and adipose tissue cultures .
22309082	0	lycopene	31,39	MMP-9	14,19	lycopene	MMP-9	MESH:C015329	4318	Chemical	Gene	pathway|nmod|START_ENTITY pathway|compound|END_ENTITY	Modulation of MMP-9 pathway by lycopene in macrophages and fibroblasts exposed to cigarette smoke .
26847233	0	lycopene	32,40	MicroRNA-let-7f-1	0,17	lycopene	MicroRNA-let-7f-1	MESH:C015329	406888	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	MicroRNA-let-7f-1 is induced by lycopene and inhibits cell proliferation and triggers apoptosis in prostate_cancer .
20482279	0	lycopene	10,18	caspase-3	22,31	lycopene	caspase-3	MESH:C015329	25402(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Effect of lycopene on caspase-3 enzyme activation in liver of methanol-intoxicated rats : comparison with fomepizole .
23906616	0	lycopene	33,41	heme_oxygenase-1	112,128	lycopene	heme oxygenase-1	MESH:C015329	15368(Tax:10090)	Chemical	Gene	pathways|amod|START_ENTITY pathways|amod|END_ENTITY	Antineuroinflammatory effects of lycopene via activation of adenosine_monophosphate-activated protein kinase-a1 / heme_oxygenase-1 pathways .
11218731	0	lycorine	48,56	TNF-alpha	89,98	lycorine	TNF-alpha	MESH:C015330	24835(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Inhibition effect of Amaryllidaceae alkaloids , lycorine and lycoricidinol on macrophage TNF-alpha production -RSB- .
22364921	0	lymphopoietin	15,28	NME1	43,47	lymphopoietin	NME1	null	4830	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|compound|END_ENTITY	Thymic stromal lymphopoietin downregulates NME1 expression and promotes invasion in human trophoblasts via the activation of STAT3 signaling pathway .
11891057	0	lymphopoietin	30,43	TSLPR	54,59	lymphopoietin	TSLPR	null	171499(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Cloning of rat thymic stromal lymphopoietin receptor -LRB- TSLPR -RRB- and characterization of genomic structure of murine Tslpr gene .
2166841	0	lymphotoxin	67,78	tumor_necrosis_factor	38,59	lymphotoxin	tumor necrosis factor	MESH:D008233	7124	Chemical	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Augmented antiproliferative effect of tumor_necrosis_factor -LRB- TNF -RRB- , lymphotoxin and glycyrrhizin in combined use with diethyldithiocarbamate on Meth A_tumor cells in vitro .
16627621	0	lysine	50,56	Asf1	18,22	lysine	Asf1	CHEBI:25094	853327(Tax:4932)	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Histone chaperone Asf1 is required for histone H3 lysine 56 acetylation , a modification associated with S phase in mitosis and meiosis .
20885444	0	lysine	28,34	Bax	62,65	lysine	Bax	CHEBI:25094	12028(Tax:10090)	Chemical	Gene	function|amod|START_ENTITY function|nmod|END_ENTITY	Single-point mutations of a lysine residue change function of Bax and Bcl-xL expressed in Bax - and Bak-less mouse embryonic fibroblasts : novel insights into the molecular mechanisms of Bax-induced apoptosis .
24556617	0	lysine	65,71	CD133	33,38	lysine	CD133	CHEBI:25094	8842	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|END_ENTITY	Post-translational regulation of CD133 by ATase1/ATase2-mediated lysine acetylation .
26896487	0	lysine	63,69	Cd40lg	75,81	lysine	Cd40lg	CHEBI:25094	21947(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|promoter promoter|amod|END_ENTITY	ThPOK represses CXXC5 , which induces methylation of histone H3 lysine 9 in Cd40lg promoter by association with SUV39H1 : implications in repression of CD40L expression in CD8 + cytotoxic T cells .
16079794	0	lysine	54,60	CoREST	22,28	lysine	CoREST	CHEBI:25094	23186	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation .
18541663	0	lysine	85,91	Ctk1	10,14	lysine	Ctk1	CHEBI:25094	853718(Tax:4932)	Chemical	Gene	START_ENTITY|nsubj|Roles Roles|nmod|END_ENTITY	Roles for Ctk1 and Spt6 in regulating the different methylation states of histone H3 lysine 36 .
23182424	0	lysine	22,28	DMC1	64,68	lysine	DMC1	CHEBI:25094	11144	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of the conserved lysine within the Walker A motif of human DMC1 .
18065378	0	lysine	35,41	DOT1	1,5	lysine	DOT1	CHEBI:25094	84444	Chemical	Gene	-RSB-|compound|START_ENTITY class|nmod|-RSB- END_ENTITY|dep|class	-LSB- DOT1 : a distinct class of histone lysine methyltransferase -RSB- .
10473582	1	lysine	62,68	DbpA	81,85	lysine	DbpA	CHEBI:25094	56449(Tax:10090)	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	Identification of critical lysine residues in DbpA required for decorin binding .
19580779	0	lysine	34,40	Dopa_decarboxylase	44,62	lysine	Dopa decarboxylase	CHEBI:25094	1644	Chemical	Gene	roles|nmod|START_ENTITY roles|nmod|END_ENTITY	Multiple roles of the active site lysine of Dopa_decarboxylase .
21159644	0	lysine	11,17	Dot1	39,43	lysine	Dot1	CHEBI:25094	84444	Chemical	Gene	START_ENTITY|ccomp|required required|nsubjpass|END_ENTITY	Histone H3 lysine 79 methyltransferase Dot1 is required for immortalization by MLL oncogenes .
21460225	0	lysine	109,115	Dot1	44,48	lysine	Dot1	CHEBI:25094	852050(Tax:4932)	Chemical	Gene	79|amod|START_ENTITY methylating|nmod|79 mediates|advcl|methylating mediates|nsubj|Evidence Evidence|dep|methyltransferase methyltransferase|dobj|END_ENTITY	Evidence that the histone methyltransferase Dot1 mediates global genomic repair by methylating histone H3 on lysine 79 .
19026780	0	lysine	40,46	EZH1	0,4	lysine	EZH1	CHEBI:25094	2145	Chemical	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency .
20614940	0	lysine	8,14	G9a	33,36	lysine	G9a	CHEBI:25094	10919	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Protein lysine methyltransferase G9a inhibitors : design , synthesis , and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines .
19219047	0	lysine	38,44	G9a-like_protein	21,37	lysine	G9a-like protein	CHEBI:25094	79813	Chemical	Gene	START_ENTITY|nsubj|basis basis|nmod|END_ENTITY	Structural basis for G9a-like_protein lysine methyltransferase inhibition by BIX-01294 .
3084796	0	lysine	29,35	H1_and_H5	90,99	lysine	H1 and H5	CHEBI:25094	3009	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Differential distribution of lysine and arginine residues in the closely related histones H1_and_H5 .
6845437	1	lysine	222,228	H2B	263,266	lysine	H2B	CHEBI:25094	8349	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Gel electrophoretic analysis of the histone chemical acetylation in the nucleosome core particles with acetic andydride revealed availability of about 14 lysine residues of histone H2A , 15-21 of H2B , 8-11 -- H3 and 6-9 -- H4 .
22659026	0	lysine	53,59	H3_histone	75,85	lysine	H3 histone	CHEBI:25094	291159(Tax:10116)	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	Cortical spreading depression differentially affects lysine methylation of H3_histone at neuroprotective genes and retrotransposon sequences .
18710948	0	lysine	31,37	IRF7	47,51	lysine	IRF7	CHEBI:25094	3665	Chemical	Gene	sites|compound|START_ENTITY sites|nmod|END_ENTITY	TRAF6 and the three C-terminal lysine sites on IRF7 are required for its ubiquitination-mediated activation by the tumor necrosis factor receptor family member latent_membrane_protein_1 .
18716661	0	lysine	15,21	Jmjd3	46,51	lysine	Jmjd3	CHEBI:25094	216850(Tax:10090)	Chemical	Gene	START_ENTITY|ccomp|required required|nsubjpass|END_ENTITY	The histone H3 lysine 27-specific demethylase Jmjd3 is required for neural commitment .
24388984	0	lysine	9,15	Klf4	28,32	lysine	Klf4	CHEBI:25094	9314	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	Critical lysine residues of Klf4 required for protein stabilization and degradation .
9390441	0	lysine	8,14	LHT1	0,4	lysine	LHT1	CHEBI:25094	834078(Tax:3702)	Chemical	Gene	transporter|amod|START_ENTITY END_ENTITY|appos|transporter	LHT1 , a lysine - and histidine-specific amino_acid transporter in arabidopsis .
20148560	0	lysine	80,86	LSD1	75,79	lysine	LSD1	CHEBI:25094	23028	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nummod|END_ENTITY	Comparative analysis of small molecules and histone substrate analogues as LSD1 lysine demethylase inhibitors .
6429126	0	lysine	13,19	LYS9	27,31	lysine	LYS9	CHEBI:25094	855786(Tax:4932)	Chemical	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Two unlinked lysine genes -LRB- LYS9 and LYS14 -RRB- are required for the synthesis of saccharopine reductase in Saccharomyces_cerevisiae .
24847881	0	lysine	12,18	MAP3K2	34,40	lysine	MAP3K2	CHEBI:25094	10746	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer .
15169884	0	lysine	82,88	NSD1	69,73	lysine	NSD1	CHEBI:25094	64324	Chemical	Gene	methyltransferase|compound|START_ENTITY methyltransferase|compound|END_ENTITY	Nizp1 , a novel multitype zinc finger protein that interacts with the NSD1 histone lysine methyltransferase through a unique C2HR motif .
19372272	0	lysine	77,83	PARP1	49,54	lysine	PARP1	CHEBI:25094	142	Chemical	Gene	residues|amod|START_ENTITY END_ENTITY|nmod|residues	Molecular mechanism of poly -LRB- ADP-ribosyl -RRB- ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites .
23575530	0	lysine	29,35	PR-SET7	54,61	lysine	PR-SET7	CHEBI:25094	387893	Chemical	Gene	-RSB-|amod|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- The biological functions of lysine methyltransferase PR-SET7 -RSB- .
24634223	0	lysine	29,35	PRDM9	66,71	lysine	PRDM9	CHEBI:25094	56979	Chemical	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	Trimethylation of histone H3 lysine 36 by human methyltransferase PRDM9 protein .
17500065	0	lysine	58,64	PTIP	0,4	lysine	PTIP	CHEBI:25094	22976	Chemical	Gene	START_ENTITY|nsubj|associates associates|compound|END_ENTITY	PTIP associates with MLL3 - and MLL4-containing histone H3 lysine 4 methyltransferase complex .
15258579	0	lysine	34,40	Pax5	84,88	lysine	Pax5	CHEBI:25094	18507(Tax:10090)	Chemical	Gene	START_ENTITY|ccomp|depends depends|nmod|END_ENTITY	B cell-specific loss of histone 3 lysine 9 methylation in the V -LRB- H -RRB- locus depends on Pax5 .
21357426	5	lysine	749,755	Pax5	809,813	lysine	Pax5	CHEBI:25094	5079	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	Moreover , p300 interacts with the C terminus of Pax5 and acetylates multiple lysine residues within the paired box DNA binding domain of Pax5 .
22583696	0	lysine	23,29	SET8	4,8	lysine	SET8	CHEBI:25094	387893	Chemical	Gene	methyltransferase|compound|START_ENTITY methyltransferase|compound|END_ENTITY	The SET8 H4K20 protein lysine methyltransferase has a long recognition sequence covering seven amino_acid residues .
12101246	0	lysine	84,90	SUV39H1	68,75	lysine	SUV39H1	CHEBI:25094	6839	Chemical	Gene	methyltransferase|compound|START_ENTITY methyltransferase|compound|END_ENTITY	Selective interactions between vertebrate polycomb homologs and the SUV39H1 histone lysine methyltransferase suggest that histone H3-K9 methylation contributes to chromosomal targeting of Polycomb group proteins .
21423664	0	lysine	18,24	SUVR4	4,9	lysine	SUVR4	CHEBI:25094	819593(Tax:3702)	Chemical	Gene	methyltransferase|compound|START_ENTITY methyltransferase|compound|END_ENTITY	The SUVR4 histone lysine methyltransferase binds ubiquitin and converts H3K9me1 to H3K9me3 on transposon chromatin in Arabidopsis .
15907489	0	lysine	10,16	Smad3	47,52	lysine	Smad3	CHEBI:25094	4088	Chemical	Gene	residues|amod|START_ENTITY Roles|nmod|residues Roles|nmod|END_ENTITY	Roles for lysine residues of the MH2 domain of Smad3 in transforming growth factor-beta signaling .
18003914	0	lysine	69,75	UTX	41,44	lysine	UTX	CHEBI:25094	7403	Chemical	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases .
10823273	0	lysine	49,55	Vitronectin	0,11	lysine	Vitronectin	CHEBI:25094	7448	Chemical	Gene	residue|compound|START_ENTITY END_ENTITY|nmod|residue	Vitronectin and substitution of a beta-strand 5A lysine residue potentiate activity-neutralization of PA inhibitor-1 by monoclonal antibodies against alpha-helix F .
25188294	0	lysine	11,17	Whsc1	39,44	lysine	Whsc1	CHEBI:25094	7468	Chemical	Gene	START_ENTITY|ccomp|promotes promotes|nsubj|END_ENTITY	Histone H3 lysine 36 methyltransferase Whsc1 promotes the association of Runx2 and p300 in the activation of bone-related genes .
3126814	0	lysine	25,31	acidic_fibroblast_growth_factor	44,75	lysine	acidic fibroblast growth factor	CHEBI:25094	281160(Tax:9913)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Reductive methylation of lysine residues in acidic_fibroblast_growth_factor : effect on mitogenic activity and heparin affinity .
6424712	0	lysine	18,24	adrenodoxin_reductase	36,57	lysine	adrenodoxin reductase	CHEBI:25094	2232	Chemical	Gene	residue|amod|START_ENTITY residue|nmod|END_ENTITY	Modification of a lysine residue of adrenodoxin_reductase , essential for complex formation with adrenodoxin .
7641075	0	lysine	8,14	aldehyde_reductase	75,93	lysine	aldehyde reductase	CHEBI:25094	317748(Tax:9913)	Chemical	Gene	residues|amod|START_ENTITY Role|nmod|residues END_ENTITY|nsubj|Role	Role of lysine residues in the nucleotides binding to bovine liver high-Km aldehyde_reductase .
8515269	0	lysine	15,21	amyloid_precursor_protein	69,94	lysine	amyloid precursor protein	CHEBI:25094	351	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	The triplet of lysine residues -LRB- Lys724-Lys725-Lys726 -RRB- of Alzheimer 's amyloid_precursor_protein plays an important role in membrane anchorage and processing .
3138240	0	lysine	30,36	apolipoprotein_B	49,65	lysine	apolipoprotein B	CHEBI:25094	338	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	A 13C NMR characterization of lysine residues in apolipoprotein_B and their role in binding to the low_density_lipoprotein_receptor .
3730052	0	lysine	44,50	apolipoprotein_B	65,81	lysine	apolipoprotein B	CHEBI:25094	338	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	The biochemistry of epsilon-amino groups of lysine residues from apolipoprotein_B of human low density lipoprotein .
11473115	0	lysine	29,35	apolipoprotein_B-100	47,67	lysine	apolipoprotein B-100	CHEBI:25094	338	Chemical	Gene	residue|amod|START_ENTITY residue|nmod|END_ENTITY	Identification of a critical lysine residue in apolipoprotein_B-100 that mediates noncovalent interaction with apolipoprotein -LRB- a -RRB- .
13130121	0	lysine	12,18	apolipoprotein_B-100	31,51	lysine	apolipoprotein B-100	CHEBI:25094	238055(Tax:10090)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Mutation of lysine residues in apolipoprotein_B-100 causes defective lipoprotein -LSB- a -RSB- formation .
11106639	0	lysine	30,36	arginyl-tRNA_synthetase	67,90	lysine	arginyl-tRNA synthetase	CHEBI:25094	5917	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	Crucial role of the high-loop lysine for the catalytic activity of arginyl-tRNA_synthetase .
16126174	0	lysine	4,10	c-Myc	23,28	lysine	c-Myc	CHEBI:25094	4609	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Six lysine residues on c-Myc are direct substrates for acetylation by p300 .
8603692	0	lysine	31,37	cdc2	26,30	lysine	cdc2	CHEBI:25094	983	Chemical	Gene	START_ENTITY|nsubj|Characterisation Characterisation|nmod|END_ENTITY	Characterisation of human cdc2 lysine 33 mutations expressed in the fission_yeast Schizosaccharomyces_pombe .
17341815	0	lysine	42,48	cholesterol_7alpha-hydroxylase	56,86	lysine	cholesterol 7alpha-hydroxylase	CHEBI:25094	1581	Chemical	Gene	START_ENTITY|nmod|level level|amod|END_ENTITY	Effects of dipeptides having a C-terminal lysine on the cholesterol_7alpha-hydroxylase mRNA level in HepG2 cells .
2506177	0	lysine	49,55	cytochrome_P-450scc	63,82	lysine	cytochrome P-450scc	CHEBI:25094	1583	Chemical	Gene	START_ENTITY|nmod|binding binding|amod|END_ENTITY	Fluorescein_isothiocyanate specifically modifies lysine 338 of cytochrome_P-450scc and inhibits adrenodoxin binding .
8323289	0	lysine	8,14	cytochrome_P450	40,55	lysine	cytochrome P450	CHEBI:25094	4051	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Role of lysine and arginine residues of cytochrome_P450 in the interaction between cytochrome_P4502B1 and NADPH-cytochrome_P450 reductase .
6250589	0	lysine	40,46	cytochrome_c	59,71	lysine	cytochrome c	CHEBI:25094	54205	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Use of specific trifluoroacetylation of lysine residues in cytochrome_c to study the reaction with cytochrome b5 , cytochrome_c1 , and cytochrome oxidase .
2159781	0	lysine	35,41	cytochrome_c_oxidase	106,126	lysine	cytochrome c oxidase	CHEBI:25094	282199(Tax:9913)	Chemical	Gene	groups|amod|START_ENTITY Effect|nmod|groups Effect|nmod|END_ENTITY	Effect of chemical modification of lysine amino groups on redox and protonmotive activity of bovine heart cytochrome_c_oxidase reconstituted in phospholipid membranes .
2517403	0	lysine	68,74	diamine_oxidase	26,41	lysine	diamine oxidase	CHEBI:25094	26	Chemical	Gene	-RSB-|compound|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- Interaction of placental diamine_oxidase with carboxyl-substituted lysine -RSB- .
10350084	0	lysine	89,95	dihydrodipicolinate_synthase	45,73	lysine	dihydrodipicolinate synthase	CHEBI:25094	819152(Tax:3702)	Chemical	Gene	biosynthesis|amod|START_ENTITY enzyme|nmod|biosynthesis END_ENTITY|appos|enzyme	The Arabidopsis_thaliana dhdps gene encoding dihydrodipicolinate_synthase , key enzyme of lysine biosynthesis , is expressed in a cell-specific manner .
8700867	0	lysine	42,48	dihydrodipicolinate_synthase	69,97	lysine	dihydrodipicolinate synthase	CHEBI:25094	542379(Tax:4577)	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Single-amino_acid substitutions eliminate lysine inhibition of maize dihydrodipicolinate_synthase .
3156054	0	lysine	11,17	fibrinogen	30,40	lysine	fibrinogen	CHEBI:25094	2244	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	C-terminal lysine residues of fibrinogen fragments essential for binding to plasminogen .
11732685	0	lysine	12,18	gastrin-binding_protein	42,65	lysine	gastrin-binding protein	CHEBI:25094	3030	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Mutation of lysine residues of the 78-kDa gastrin-binding_protein reduces gastrin binding .
15371351	0	lysine	63,69	grappa	24,30	lysine	grappa	CHEBI:25094	40793(Tax:7227)	Chemical	Gene	START_ENTITY|nsubj|Characterization Characterization|nmod|gene gene|compound|END_ENTITY	Characterization of the grappa gene , the Drosophila histone H3 lysine 79 methyltransferase .
19080631	0	lysine	12,18	hMLH1	70,75	lysine	hMLH1	CHEBI:25094	4292	Chemical	Gene	START_ENTITY|ccomp|associated associated|nmod|expression expression|nmod|END_ENTITY	-LSB- Histone H3 lysine 9 methylation is associated with the expression of hMLH1 and DNA methylation in gastric_cancer cells -RSB- .
18194664	0	lysine	37,43	heme_oxygenase-1	56,72	lysine	heme oxygenase-1	CHEBI:25094	24451(Tax:10116)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Mass spectrometric identification of lysine residues of heme_oxygenase-1 that are involved in its interaction with NADPH-cytochrome P450 reductase .
23982278	0	lysine	17,23	interleukin-8	51,64	lysine	interleukin-8	CHEBI:25094	3576	Chemical	Gene	interactions|amod|START_ENTITY interactions|nmod|END_ENTITY	Investigation of lysine side chain interactions of interleukin-8 with heparin and other glycosaminoglycans studied by a methylation-NMR approach .
21106372	0	lysine	71,77	lysyl_oxidase	11,24	lysine	lysyl oxidase	CHEBI:25094	4015	Chemical	Gene	Control|nmod|START_ENTITY Control|nmod|activity activity|amod|END_ENTITY	Control of lysyl_oxidase activity through site-specific deuteration of lysine .
171264	0	lysine	31,37	malate_dehydrogenase	69,89	lysine	malate dehydrogenase	CHEBI:25094	4200	Chemical	Gene	Identification|nmod|START_ENTITY END_ENTITY|nsubj|Identification	Identification of an essential lysine in porcine heart mitochondrial malate_dehydrogenase .
10350461	0	lysine	28,34	myosin	46,52	lysine	myosin	CHEBI:25094	79784	Chemical	Gene	residue|compound|START_ENTITY residue|nmod|END_ENTITY	Trinitrophenylated reactive lysine residue in myosin detects lever arm movement during the consecutive steps of ATP hydrolysis .
6216915	0	lysine	66,72	myosin	84,90	lysine	myosin	CHEBI:25094	79784	Chemical	Gene	residue|compound|START_ENTITY residue|nmod|END_ENTITY	Spatial relationship between a fast-reacting thiol and a reactive lysine residue of myosin subfragment 1 .
8349587	0	lysine	39,45	myosin_heavy_chain	61,79	lysine	myosin heavy chain	CHEBI:25094	100009284(Tax:9986)	Chemical	Gene	residue|compound|START_ENTITY residue|nmod|END_ENTITY	Microheterogeneity around the reactive lysine residue in the myosin_heavy_chain from rabbit skeletal muscle .
20736	0	lysine	31,37	ornithine_decarboxylase	51,74	lysine	ornithine decarboxylase	CHEBI:25094	4953	Chemical	Gene	Evidence|nmod|START_ENTITY Evidence|nmod|END_ENTITY	Evidence of decarboxylation of lysine by mammalian ornithine_decarboxylase .
14695212	0	lysine	69,75	p53	50,53	lysine	p53	CHEBI:25094	7157	Chemical	Gene	residues|amod|START_ENTITY END_ENTITY|nmod|residues	Induction of PIG3 and NOXA through acetylation of p53 at 320 and 373 lysine residues as a mechanism for apoptotic cell death by histone deacetylase inhibitors .
20080798	0	lysine	60,66	p65	82,85	lysine	p65	CHEBI:25094	5970	Chemical	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	Regulation of NF-kappaB by NSD1/FBXL11-dependent reversible lysine methylation of p65 .
25791343	0	lysine	74,80	p65	99,102	lysine	p65	CHEBI:25094	5970	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	Epigenetic regulation of polyomavirus_JC involves acetylation of specific lysine residues in NF-kB p65 .
25791343	0	lysine	74,80	p65	99,102	lysine	p65	CHEBI:25094	5970	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	Epigenetic regulation of polyomavirus_JC involves acetylation of specific lysine residues in NF-kB p65 .
8641450	0	lysine	27,33	phosphoglycerate_kinase	74,97	lysine	phosphoglycerate kinase	CHEBI:25094	850370(Tax:4932)	Chemical	Gene	role|nmod|START_ENTITY END_ENTITY|nsubj|role	The role of the C-terminal lysine in the hinge bending mechanism of yeast phosphoglycerate_kinase .
2551068	0	lysine	195,201	plasmin	219,226	lysine	plasmin	CHEBI:25094	5340	Chemical	Gene	sites|amod|START_ENTITY sites|nmod|END_ENTITY	Inhibition by tranexamic_acid of the conversion of single-chain tissue plasminogen activator to its two chain form by plasmin : the presence on tissue plasminogen activator of a site to bind with lysine binding sites of plasmin .
19328070	0	lysine	37,43	rap80	90,95	lysine	rap80	CHEBI:25094	51720	Chemical	Gene	preference|amod|START_ENTITY preference|nmod|END_ENTITY	Linkage-specific avidity defines the lysine 63-linked polyubiquitin-binding preference of rap80 .
20053725	0	lysine	12,18	thyroid_hormone_receptor-alpha1	26,57	lysine	thyroid hormone receptor-alpha1	CHEBI:25094	7067	Chemical	Gene	START_ENTITY|nmod|domain domain|amod|END_ENTITY	A conserved lysine in the thyroid_hormone_receptor-alpha1 DNA-binding domain , mutated in hepatocellular_carcinoma , serves as a sensor for transcriptional regulation .
1349282	0	lysine	21,27	tissue_transglutaminase	82,105	lysine	tissue transglutaminase	CHEBI:25094	7052	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	The carboxy-terminal lysine of alpha_B-crystallin is an amine-donor substrate for tissue_transglutaminase .
17129343	0	lysine	67,73	tissue_transglutaminase	14,37	lysine	tissue transglutaminase	CHEBI:25094	7052	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of tissue_transglutaminase and epsilon -LRB- gamma-glutamyl -RRB- lysine cross-linking in human hypertrophic_scar .
10028184	0	lysine350	18,27	deoxyhypusine_synthase	37,59	lysine350	deoxyhypusine synthase	null	856465(Tax:4932)	Chemical	Gene	Identification|nmod|START_ENTITY END_ENTITY|nsubj|Identification	Identification of lysine350 of yeast deoxyhypusine_synthase as the site of enzyme intermediate formation .
6133658	0	lysine_vasopressin	40,58	Plasma_calcitonin_and_ACTH	0,26	lysine vasopressin	Plasma calcitonin and ACTH	MESH:D008236	5443	Chemical	Gene	responses|nmod|START_ENTITY responses|amod|END_ENTITY	Plasma_calcitonin_and_ACTH responses to lysine_vasopressin , calcium and pentagastrin in a patient with medullary_thyroid_carcinoma associated with Cushing 's _ syndrome .
2172283	0	lysine_vasopressin	86,104	corticotropin-releasing_hormone	40,71	lysine vasopressin	corticotropin-releasing hormone	MESH:D008236	1392	Chemical	Gene	combined|nmod|START_ENTITY combined|nsubj|Effects Effects|nmod|administration administration|nmod|END_ENTITY	Effects of repetitive administration of corticotropin-releasing_hormone combined with lysine_vasopressin on plasma adrenocorticotropin and cortisol levels in secondary adrenocortical_insufficiency .
1312168	0	lysine_vasopressin	137,155	interleukin-1_beta	58,76	lysine vasopressin	interleukin-1 beta	MESH:D008236	3553	Chemical	Gene	combined|nmod|START_ENTITY combined|nsubj|Effects Effects|nmod|administration administration|nmod|END_ENTITY	Effects of repetitive administration of recombinant human interleukin-1_beta , an analog or corticotropin-releasing_hormone combined with lysine_vasopressin on rats with glucocorticoid-induced secondary adrenocortical_insufficiency .
10082375	0	lysines	18,25	single-strand_binding_protein	69,98	lysines	single-strand binding protein	null	8319221(Tax:562)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of the 6 lysines and the terminal amine of Escherichia_coli single-strand_binding_protein in its binding of single-stranded DNA .
25896349	0	lysophosphatidate	52,69	autotaxin	14,23	lysophosphatidate	autotaxin	null	18606(Tax:10090)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of autotaxin expression and secretion by lysophosphatidate and sphingosine-1-phosphate .
24050723	0	lysophosphatidic_acid	24,45	Autotaxin	0,9	lysophosphatidic acid	Autotaxin	MESH:C032881	18606(Tax:10090)	Chemical	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	Autotaxin production of lysophosphatidic_acid mediates allergic_asthmatic inflammation .
7554142	0	lysophosphatidic_acid	11,32	Ca2	71,74	lysophosphatidic acid	Ca2	MESH:C032881	54231(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of lysophosphatidic_acid , a novel lipid mediator , on cytosolic Ca2 + and contractility in cultured rat mesangial cells .
20965247	0	lysophosphatidic_acid	45,66	Connective_tissue_growth_factor	0,31	lysophosphatidic acid	Connective tissue growth factor	MESH:C032881	1490	Chemical	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Connective_tissue_growth_factor induction by lysophosphatidic_acid requires transactivation of transforming growth factor type b receptors and the JNK pathway .
16519534	0	lysophosphatidic_acid	31,52	Csk	0,3	lysophosphatidic acid	Csk	MESH:C032881	12988(Tax:10090)	Chemical	Gene	inhibition|amod|START_ENTITY mediates|dobj|inhibition mediates|nsubj|END_ENTITY	Csk mediates G-protein-coupled lysophosphatidic_acid receptor-induced inhibition of membrane-bound guanylyl cyclase activity .
15781636	0	lysophosphatidic_acid	55,76	Cyclooxygenase-2	0,16	lysophosphatidic acid	Cyclooxygenase-2	MESH:C032881	5743	Chemical	Gene	START_ENTITY|nsubj|functions functions|amod|END_ENTITY	Cyclooxygenase-2 functions as a downstream mediator of lysophosphatidic_acid to promote aggressive_behavior in ovarian_carcinoma cells .
11040035	0	lysophosphatidic_acid	30,51	EDG-2	76,81	lysophosphatidic acid	EDG-2	MESH:C032881	1902	Chemical	Gene	receptors|amod|START_ENTITY comparisons|nmod|receptors Functional|dobj|comparisons VZG-1|dep|Functional VZG-1|dep|END_ENTITY	Functional comparisons of the lysophosphatidic_acid receptors , LP -LRB- A1 -RRB- / VZG-1 / EDG-2 , LP -LRB- A2 -RRB- / EDG-4 , and LP -LRB- A3 -RRB- / EDG-7 in neuronal cell lines using a retrovirus expression system .
11040035	0	lysophosphatidic_acid	30,51	EDG-7	108,113	lysophosphatidic acid	EDG-7	MESH:C032881	23566	Chemical	Gene	receptors|amod|START_ENTITY comparisons|nmod|receptors Functional|dobj|comparisons VZG-1|dep|Functional VZG-1|dep|END_ENTITY	Functional comparisons of the lysophosphatidic_acid receptors , LP -LRB- A1 -RRB- / VZG-1 / EDG-2 , LP -LRB- A2 -RRB- / EDG-4 , and LP -LRB- A3 -RRB- / EDG-7 in neuronal cell lines using a retrovirus expression system .
16018784	0	lysophosphatidic_acid	69,90	EDG-7	59,64	lysophosphatidic acid	EDG-7	MESH:C032881	23566	Chemical	Gene	receptor|amod|START_ENTITY Expression|appos|receptor Expression|nmod|endothelial_cell_differentiation_gene_7 endothelial_cell_differentiation_gene_7|appos|END_ENTITY	Expression of the endothelial_cell_differentiation_gene_7 -LRB- EDG-7 -RRB- , a lysophosphatidic_acid receptor , in ovarian_tumor .
10488122	0	lysophosphatidic_acid	94,115	EDG7	84,88	lysophosphatidic acid	EDG7	MESH:C032881	23566	Chemical	Gene	cloning|nmod|START_ENTITY cloning|nmod|receptor receptor|appos|END_ENTITY	Molecular cloning and characterization of a novel human G-protein-coupled receptor , EDG7 , for lysophosphatidic_acid .
10891327	0	lysophosphatidic_acid	77,98	EDG7	21,25	lysophosphatidic acid	EDG7	MESH:C032881	23566	Chemical	Gene	receptor|nmod|START_ENTITY Identification|appos|receptor Identification|nmod|variant variant|compound|END_ENTITY	Identification of an EDG7 variant , HOFNH30 , a G-protein-coupled receptor for lysophosphatidic_acid .
10727522	0	lysophosphatidic_acid	44,65	Edg-7	76,81	lysophosphatidic acid	Edg-7	MESH:C032881	23566	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Molecular cloning and characterization of a lysophosphatidic_acid receptor , Edg-7 , expressed in prostate .
11313151	0	lysophosphatidic_acid	22,43	Edg7	17,21	lysophosphatidic acid	Edg7	MESH:C032881	65086(Tax:10090)	Chemical	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	The mouse lp -LRB- A3 -RRB- / Edg7 lysophosphatidic_acid receptor gene : genomic structure , chromosomal localization , and expression pattern .
19864325	0	lysophosphatidic_acid	34,55	Epidermal_growth_factor	0,23	lysophosphatidic acid	Epidermal growth factor	MESH:C032881	1950	Chemical	Gene	START_ENTITY|nsubj|increases increases|compound|END_ENTITY	Epidermal_growth_factor increases lysophosphatidic_acid production in human ovarian_cancer cells : roles for phospholipase_D2 and receptor transactivation .
10551845	0	lysophosphatidic_acid	118,139	Gab1	36,40	lysophosphatidic acid	Gab1	MESH:C032881	2549	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|signaling signaling|compound|END_ENTITY	An epidermal_growth_factor_receptor / Gab1 signaling pathway is required for activation of phosphoinositide 3-kinase by lysophosphatidic_acid .
10799543	0	lysophosphatidic_acid	46,67	Gelsolin	0,8	lysophosphatidic acid	Gelsolin	MESH:C032881	296654(Tax:10116)	Chemical	Gene	binding|nmod|START_ENTITY binding|nmod:npmod|END_ENTITY	Gelsolin binding and cellular presentation of lysophosphatidic_acid .
9774337	0	lysophosphatidic_acid	74,95	Gelsolin	0,8	lysophosphatidic acid	Gelsolin	MESH:C032881	2934	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Gelsolin and functionally similar actin-binding proteins are regulated by lysophosphatidic_acid .
12393875	0	lysophosphatidic_acid	18,39	LPA1	40,44	lysophosphatidic acid	LPA1	MESH:C032881	1902	Chemical	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	Rac activation by lysophosphatidic_acid LPA1 receptors through the guanine_nucleotide exchange factor Tiam1 .
16263766	0	lysophosphatidic_acid	104,125	LPA1	99,103	lysophosphatidic acid	LPA1	MESH:C032881	14745(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|requirement requirement|nmod|cholesterol cholesterol|nmod|endocytosis endocytosis|nmod|END_ENTITY	A requirement for membrane cholesterol in the beta-arrestin - and clathrin-dependent endocytosis of LPA1 lysophosphatidic_acid receptors .
16716145	0	lysophosphatidic_acid	75,96	LPA1	109,113	lysophosphatidic acid	LPA1	MESH:C032881	1902	Chemical	Gene	receptor-1|amod|START_ENTITY receptor-1|appos|END_ENTITY	Integrin signalling regulates the nuclear localization and function of the lysophosphatidic_acid receptor-1 -LRB- LPA1 -RRB- in mammalian cells .
18066075	0	lysophosphatidic_acid	4,25	LPA1	35,39	lysophosphatidic acid	LPA1	MESH:C032881	1902	Chemical	Gene	links|amod|START_ENTITY links|compound|END_ENTITY	The lysophosphatidic_acid receptor LPA1 links pulmonary_fibrosis to lung_injury by mediating fibroblast recruitment and vascular leak .
18089565	0	lysophosphatidic_acid	30,51	LPA1	122,126	lysophosphatidic acid	LPA1	MESH:C032881	14745(Tax:10090)	Chemical	Gene	regulate|dobj|START_ENTITY regulate|dep|dependent dependent|nmod|internalization internalization|nmod|receptor receptor|compound|END_ENTITY	Different mechanisms regulate lysophosphatidic_acid -LRB- LPA -RRB- - dependent versus phorbol_ester-dependent internalization of the LPA1 receptor .
18978343	0	lysophosphatidic_acid	12,33	LPA1	44,48	lysophosphatidic acid	LPA1	MESH:C032881	116744(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY role|nmod|receptor role|appos|END_ENTITY	The role of lysophosphatidic_acid receptor -LRB- LPA1 -RRB- in the oxygen-induced retinal_ganglion cell degeneration .
19129242	0	lysophosphatidic_acid	134,155	LPA1	0,4	lysophosphatidic acid	LPA1	MESH:C032881	1902	Chemical	Gene	response|nmod|START_ENTITY cells|nmod|response migration|nmod|cells stimulation|nmod|migration mediate|dobj|stimulation mediate|nsubj|receptors receptors|compound|END_ENTITY	LPA1 receptors mediate stimulation , whereas LPA2 receptors mediate inhibition , of migration of pancreatic_cancer cells in response to lysophosphatidic_acid and malignant_ascites .
19306925	0	lysophosphatidic_acid	19,40	LPA1	42,46	lysophosphatidic acid	LPA1	MESH:C032881	1902	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Dual regulation of lysophosphatidic_acid -LRB- LPA1 -RRB- receptor signalling by Ral and GRK .
21244430	0	lysophosphatidic_acid	58,79	LPA1	13,17	lysophosphatidic acid	LPA1	MESH:C032881	116744(Tax:10116)	Chemical	Gene	receptor-mediated|advcl|START_ENTITY receptor-mediated|nsubj|Unmasking Unmasking|nmod|END_ENTITY	Unmasking of LPA1 receptor-mediated migration response to lysophosphatidic_acid by interleukin-1b-induced attenuation of Rho signaling pathways in rat astrocytes .
22686545	0	lysophosphatidic_acid	55,76	LPA1	77,81	lysophosphatidic acid	LPA1	MESH:C032881	116744(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Lipid phosphate phosphatase inhibitors locally amplify lysophosphatidic_acid LPA1 receptor signalling in rat brain cryosections without affecting global LPA degradation .
25424429	0	lysophosphatidic_acid	110,131	LPA1	190,194	lysophosphatidic acid	LPA1	MESH:C032881	1902	Chemical	Gene	cells|nmod|START_ENTITY regulation|nmod|cells regulation|dep|roles roles|nmod|receptor receptor|compound|END_ENTITY	Convergent regulation of neuronal differentiation and Erk and Akt kinases in human neural progenitor cells by lysophosphatidic_acid , sphingosine_1-phosphate , and LIF : specific roles for the LPA1 receptor .
26700247	0	lysophosphatidic_acid	54,75	LPA1	76,80	lysophosphatidic acid	LPA1	MESH:C032881	14745(Tax:10090)	Chemical	Gene	results|amod|START_ENTITY results|compound|END_ENTITY	Both genetic deletion and pharmacological blockade of lysophosphatidic_acid LPA1 receptor results in increased_alcohol_consumption .
12554733	0	lysophosphatidic_acid	48,69	LPA3	106,110	lysophosphatidic acid	LPA3	MESH:C032881	23566	Chemical	Gene	analogue|nmod|START_ENTITY Identification|nmod|analogue Identification|nmod|agonist agonist|nmod|receptor receptor|compound|END_ENTITY	Identification of a phosphothionate analogue of lysophosphatidic_acid -LRB- LPA -RRB- as a selective agonist of the LPA3 receptor .
12770838	0	lysophosphatidic_acid	22,43	LPA3	44,48	lysophosphatidic acid	LPA3	MESH:C032881	65086(Tax:10090)	Chemical	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	Selective blockade of lysophosphatidic_acid LPA3 receptors reduces murine renal_ischemia-reperfusion injury .
15225728	0	lysophosphatidic_acid	52,73	LPA3	129,133	lysophosphatidic acid	LPA3	MESH:C032881	23566	Chemical	Gene	antagonists|amod|START_ENTITY compounds|nmod|antagonists series|nmod|compounds series|dep|development development|nmod|antagonist antagonist|compound|END_ENTITY	A novel series of 2-pyridyl-containing compounds as lysophosphatidic_acid receptor antagonists : development of a nonhydrolyzable LPA3 receptor-selective antagonist .
21464938	0	lysophosphatidic_acid	67,88	MIP-1b	97,103	lysophosphatidic acid	MIP-1b	MESH:C032881	6351	Chemical	Gene	release|amod|START_ENTITY release|compound|END_ENTITY	LPA5 is abundantly expressed by human mast cells and important for lysophosphatidic_acid induced MIP-1b release .
19864456	0	lysophosphatidic_acid	70,91	Rap1B	8,13	lysophosphatidic acid	Rap1B	MESH:C032881	5908	Chemical	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Role of Rap1B and tumor suppressor PTEN in the negative regulation of lysophosphatidic_acid -- induced migration by isoproterenol in glioma cells .
10359601	0	lysophosphatidic_acid	22,43	RhoA	14,18	lysophosphatidic acid	RhoA	MESH:C032881	11848(Tax:10090)	Chemical	Gene	subunits|amod|START_ENTITY END_ENTITY|nmod|subunits	Activation of RhoA by lysophosphatidic_acid and Galpha12/13 subunits in neuronal cells : induction of neurite_retraction .
8798377	0	lysophosphatidic_acid	118,139	SH-PTP1	99,106	lysophosphatidic acid	SH-PTP1	MESH:C032881	5777	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	G-protein beta gamma subunits mediate specific phosphorylation of the protein-tyrosine phosphatase SH-PTP1 induced by lysophosphatidic_acid .
21118579	0	lysophosphatidic_acid	15,36	TRPV1	76,81	lysophosphatidic acid	TRPV1	MESH:C032881	83810(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|potentiation potentiation|nmod|END_ENTITY	Involvement of lysophosphatidic_acid in bone_cancer_pain by potentiation of TRPV1 via PKC pathway in dorsal root ganglion neurons .
20177148	0	lysophosphatidic_acid	23,44	VEGF_and_stromal_cell-derived_factor-1_alpha	69,113	lysophosphatidic acid	VEGF and stromal cell-derived factor-1 alpha	MESH:C032881	7422	Chemical	Gene	secretion|amod|START_ENTITY secretion|nmod|END_ENTITY	Ovarian_cancer-derived lysophosphatidic_acid stimulates secretion of VEGF_and_stromal_cell-derived_factor-1_alpha from human mesenchymal stem cells .
15256273	0	lysophosphatidic_acid	77,98	adrenomedullin	11,25	lysophosphatidic acid	adrenomedullin	MESH:C032881	25026(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Effects Effects|nmod|END_ENTITY	Effects of adrenomedullin on cell proliferation in rat adventitia induced by lysophosphatidic_acid .
15262182	0	lysophosphatidic_acid	82,103	connective_tissue_growth_factor	13,44	lysophosphatidic acid	connective tissue growth factor	MESH:C032881	1490	Chemical	Gene	cells|acl|START_ENTITY Induction|nmod|cells Induction|nmod|END_ENTITY	Induction of connective_tissue_growth_factor -LRB- CTGF -RRB- in human endothelial cells by lysophosphatidic_acid , sphingosine-1-phosphate , and platelets .
8573118	0	lysophosphatidic_acid	109,130	cyclin-dependent_kinase-4	15,40	lysophosphatidic acid	cyclin-dependent kinase-4	MESH:C032881	1019	Chemical	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of cyclin-dependent_kinase-4 and cyclin_D1 in neonatal beta cells after mitogenic stimulation by lysophosphatidic_acid .
16376882	0	lysophosphatidic_acid	56,77	cyclooxygenase-2	23,39	lysophosphatidic acid	cyclooxygenase-2	MESH:C032881	5743	Chemical	Gene	presentation|amod|START_ENTITY role|nmod|presentation plays|dobj|role plays|nsubj|induction induction|nmod|END_ENTITY	Selective induction of cyclooxygenase-2 plays a role in lysophosphatidic_acid regulated Fas_ligand cell surface presentation .
18802115	0	lysophosphatidic_acid	20,41	cyclooxygenase-2	45,61	lysophosphatidic acid	cyclooxygenase-2	MESH:C032881	5743	Chemical	Gene	START_ENTITY|nmod|induction induction|amod|END_ENTITY	Stimulatory role of lysophosphatidic_acid in cyclooxygenase-2 induction by synovial fluid of patients with rheumatoid_arthritis in fibroblast-like synovial cells .
25783839	0	lysophosphatidic_acid	84,105	cyclooxygenase-2	27,43	lysophosphatidic acid	cyclooxygenase-2	MESH:C032881	5743	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Attenuation of LPS-induced cyclooxygenase-2 and inducible_NO_synthase expression by lysophosphatidic_acid in macrophages .
10551845	0	lysophosphatidic_acid	118,139	epidermal_growth_factor_receptor	3,35	lysophosphatidic acid	epidermal growth factor receptor	MESH:C032881	1956	Chemical	Gene	required|nmod|START_ENTITY END_ENTITY|parataxis|required	An epidermal_growth_factor_receptor / Gab1 signaling pathway is required for activation of phosphoinositide 3-kinase by lysophosphatidic_acid .
10649436	0	lysophosphatidic_acid	65,86	epidermal_growth_factor_receptor	20,52	lysophosphatidic acid	epidermal growth factor receptor	MESH:C032881	24329(Tax:10116)	Chemical	Gene	function|nmod|START_ENTITY function|nsubj|Characterization Characterization|nmod|END_ENTITY	Characterization of epidermal_growth_factor_receptor function in lysophosphatidic_acid signaling in PC12 cells .
11165237	0	lysophosphatidic_acid	136,157	epidermal_growth_factor_receptor	72,104	lysophosphatidic acid	epidermal growth factor receptor	MESH:C032881	1956	Chemical	Gene	regulates|nmod|START_ENTITY regulates|dobj|transactivation transactivation|nmod|END_ENTITY	An endogenous redox molecule , thioredoxin , regulates transactivation of epidermal_growth_factor_receptor and activation of NF-kappaB by lysophosphatidic_acid .
12069816	0	lysophosphatidic_acid	56,77	epidermal_growth_factor_receptor	20,52	lysophosphatidic acid	epidermal growth factor receptor	MESH:C032881	1956	Chemical	Gene	receptors|amod|START_ENTITY Trans-regulation|nmod|receptors Trans-regulation|nmod|END_ENTITY	Trans-regulation of epidermal_growth_factor_receptor by lysophosphatidic_acid and G protein-coupled receptors .
12548551	0	lysophosphatidic_acid	100,121	epidermal_growth_factor_receptor	127,159	lysophosphatidic acid	epidermal growth factor receptor	MESH:C032881	13649(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|transactivation transactivation|compound|END_ENTITY	Dissociation of focal_adhesion_kinase and paxillin tyrosine phosphorylation induced by bombesin and lysophosphatidic_acid from epidermal_growth_factor_receptor transactivation in Swiss_3T3 cells .
14580235	0	lysophosphatidic_acid	30,51	epidermal_growth_factor_receptor	89,121	lysophosphatidic acid	epidermal growth factor receptor	MESH:C032881	1956	Chemical	Gene	response|nmod|START_ENTITY activation|nmod|response requires|nsubj|activation requires|nmod|END_ENTITY	Ras activation in response to lysophosphatidic_acid requires a permissive input from the epidermal_growth_factor_receptor .
20074357	0	lysophosphatidic_acid	127,148	epidermal_growth_factor_receptor	32,64	lysophosphatidic acid	epidermal growth factor receptor	MESH:C032881	1956	Chemical	Gene	protein-mediated|nmod|START_ENTITY protein-mediated|nsubj|requirement requirement|nmod|END_ENTITY	Differential requirement of the epidermal_growth_factor_receptor for G protein-mediated activation of transcription factors by lysophosphatidic_acid .
9468525	0	lysophosphatidic_acid	54,75	epidermal_growth_factor_receptor	89,121	lysophosphatidic acid	epidermal growth factor receptor	MESH:C032881	13649(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|nmod|END_ENTITY	The G-protein G13 but not G12 mediates signaling from lysophosphatidic_acid receptor via epidermal_growth_factor_receptor to Rho .
17135294	0	lysophosphatidic_acid	39,60	gelsolin	102,110	lysophosphatidic acid	gelsolin	MESH:C032881	2934	Chemical	Gene	factor|amod|START_ENTITY Modifications|nmod|factor Modifications|nmod|END_ENTITY	Modifications of cellular responses to lysophosphatidic_acid and platelet-activating factor by plasma gelsolin .
19297419	0	lysophosphatidic_acid	66,87	lysophospholipase_D	20,39	lysophosphatidic acid	lysophospholipase D	MESH:C032881	5168	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Altered activity of lysophospholipase_D , which produces bioactive lysophosphatidic_acid and choline , in serum from women with pathological pregnancy .
12837850	0	lysophosphatidic_acid	46,67	phospholipase_D	8,23	lysophosphatidic acid	phospholipase D	MESH:C032881	2822	Chemical	Gene	synthesis|amod|START_ENTITY END_ENTITY|nmod|synthesis	Role of phospholipase_D in agonist-stimulated lysophosphatidic_acid synthesis by ovarian_cancer cells .
15926888	0	lysophosphatidic_acid	80,101	phospholipase_D	48,63	lysophosphatidic acid	phospholipase D	MESH:C032881	2822	Chemical	Gene	generates|dobj|START_ENTITY generates|nsubj|END_ENTITY	Brown recluse spider -LRB- Loxosceles reclusa -RRB- venom phospholipase_D -LRB- PLD -RRB- generates lysophosphatidic_acid -LRB- LPA -RRB- .
9545198	0	lysophosphatidic_acid	36,57	phospholipase_D	10,25	lysophosphatidic acid	phospholipase D	MESH:C032881	2822	Chemical	Gene	generates|xcomp|START_ENTITY generates|advmod|END_ENTITY	Exogenous phospholipase_D generates lysophosphatidic_acid and activates Ras , Rho and Ca2 + signaling pathways .
14769825	0	lysophosphatidic_acid	63,84	phospholipase_D1	8,24	lysophosphatidic acid	phospholipase D1	MESH:C032881	5337	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of phospholipase_D1 in the regulation of mTOR activity by lysophosphatidic_acid .
15240009	0	lysophosphatidic_acid	26,47	serum_response_factor	61,82	lysophosphatidic acid	serum response factor	MESH:C032881	6722	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Protein kinase A inhibits lysophosphatidic_acid induction of serum_response_factor via alterations in the actin cytoskeleton .
25760533	0	lysophosphatidic_acids	18,40	soluble_epoxide_hydrolase	70,95	lysophosphatidic acids	soluble epoxide hydrolase	MESH:D008246	2053	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|nmod|END_ENTITY	The metabolism of lysophosphatidic_acids by allelic variants of human soluble_epoxide_hydrolase .
11243876	0	lysophosphatidylcholine	50,73	COX-2	31,36	lysophosphatidylcholine	COX-2	MESH:D008244	4513	Chemical	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	Signaling mechanism underlying COX-2 induction by lysophosphatidylcholine .
9084506	0	lysophosphatidylcholine	33,56	ICAM-1	14,20	lysophosphatidylcholine	ICAM-1	MESH:D008244	3383	Chemical	Gene	promoter|nmod|START_ENTITY promoter|compound|END_ENTITY	Activation of ICAM-1 promoter by lysophosphatidylcholine : possible involvement of protein tyrosine kinases .
22511767	0	lysophosphatidylcholine	67,90	Lysophosphatidylcholine_acyltransferase_3	0,41	lysophosphatidylcholine	Lysophosphatidylcholine acyltransferase 3	MESH:D008244	14792(Tax:10090)	Chemical	Gene	accumulation|compound|START_ENTITY accumulation|amod|END_ENTITY	Lysophosphatidylcholine_acyltransferase_3 knockdown-mediated liver lysophosphatidylcholine accumulation promotes very low density lipoprotein production by enhancing microsomal_triglyceride_transfer_protein expression .
25443158	0	lysophosphatidylcholine	100,123	MCP-1	59,64	lysophosphatidylcholine	MCP-1	MESH:D008244	6347	Chemical	Gene	upregulate|advcl|START_ENTITY upregulate|dobj|expression expression|compound|END_ENTITY	Activated microglia in ischemic_stroke penumbra upregulate MCP-1 and CCR2 expression in response to lysophosphatidylcholine derived from adjacent neurons and astrocytes .
24385052	0	lysophosphatidylcholine	21,44	PPARa	75,80	lysophosphatidylcholine	PPARa	MESH:D008244	19013(Tax:10090)	Chemical	Gene	homeostasis|amod|START_ENTITY homeostasis|nmod|END_ENTITY	Gemfibrozil disrupts lysophosphatidylcholine and bile_acid homeostasis via PPARa and its relevance to hepatotoxicity .
15721011	0	lysophosphatidylcholine	175,198	Paraoxonase_1	0,13	lysophosphatidylcholine	Paraoxonase 1	MESH:D008244	18979(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY enhances|parataxis|role enhances|nsubj|END_ENTITY	Paraoxonase_1 -LRB- PON1 -RRB- enhances HDL-mediated macrophage cholesterol efflux via the ABCA1 transporter in association with increased HDL binding to the cells : a possible role for lysophosphatidylcholine .
23973256	0	lysophosphatidylcholine	63,86	connexin43	41,51	lysophosphatidylcholine	connexin43	MESH:D008244	24392(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	PKC mediates serine phosphorylation of connexin43 induced by lysophosphatidylcholine in neonatal rat cardiomyocytes .
9614091	0	lysophosphatidylcholine	67,90	endothelial_nitric-oxide_synthase	30,63	lysophosphatidylcholine	endothelial nitric-oxide synthase	MESH:D008244	4846	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of endothelial_nitric-oxide_synthase by lysophosphatidylcholine .
12052468	0	lysophosphatidylcholine	69,92	extracellular-superoxide_dismutase	18,52	lysophosphatidylcholine	extracellular-superoxide dismutase	MESH:D008244	6649	Chemical	Gene	increased|nmod|START_ENTITY increased|nsubjpass|expression expression|nmod|END_ENTITY	The expression of extracellular-superoxide_dismutase is increased by lysophosphatidylcholine in human monocytic U937 cells .
19407215	0	lysophosphatidylcholine	8,31	intestinal_alkaline_phosphatase	48,79	lysophosphatidylcholine	intestinal alkaline phosphatase	MESH:D008244	248	Chemical	Gene	Role|nmod|START_ENTITY END_ENTITY|nsubj|Role	Role of lysophosphatidylcholine in brush-border intestinal_alkaline_phosphatase release and restoration .
12200757	0	lysophosphatidylcholine	152,175	monocyte_chemoattractant_protein-1	46,80	lysophosphatidylcholine	monocyte chemoattractant protein-1	MESH:D008244	6347	Chemical	Gene	enhances|advcl|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Glycoxidized low-density lipoprotein enhances monocyte_chemoattractant_protein-1 mRNA expression in human umbilical vein endothelial cells : relation to lysophosphatidylcholine contents and inhibition by nitric_oxide donor .
12703402	0	lysophosphatidylcholine	12,35	monocyte_chemoattractant_protein-1	53,87	lysophosphatidylcholine	monocyte chemoattractant protein-1	MESH:D008244	281043(Tax:9913)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|cells cells|amod|END_ENTITY	-LSB- Effects of lysophosphatidylcholine on expression of monocyte_chemoattractant_protein-1 in glomerular endothelial cells -RSB- .
7492774	0	lysophosphatidylcholine	22,45	secretory_phospholipase_A2	91,117	lysophosphatidylcholine	secretory phospholipase A2	MESH:D008244	8399	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	An essential role for lysophosphatidylcholine in the inhibition of platelet_aggregation by secretory_phospholipase_A2 .
11742586	0	lysophosphatidylcholine	10,33	vascular_endothelial_growth_factor	51,85	lysophosphatidylcholine	vascular endothelial growth factor	MESH:D008244	7422	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of lysophosphatidylcholine on expression of vascular_endothelial_growth_factor in ECV304 cells .
17765871	0	lysophosphatidylinositol	29,53	GPR55	18,23	lysophosphatidylinositol	GPR55	MESH:C025449	9290	Chemical	Gene	receptor|amod|START_ENTITY Identification|nmod|receptor Identification|nmod|END_ENTITY	Identification of GPR55 as a lysophosphatidylinositol receptor .
20370712	0	lysophosphatidylinositol	9,33	GPR55	0,5	lysophosphatidylinositol	GPR55	MESH:C025449	9290	Chemical	Gene	receptor|amod|START_ENTITY END_ENTITY|appos|receptor	GPR55 , a lysophosphatidylinositol receptor with cannabinoid sensitivity ?
20735417	1	lysophosphatidylinositol	170,194	GPR55	264,269	lysophosphatidylinositol	GPR55	MESH:C025449	9290	Chemical	Gene	agonist|nsubj|START_ENTITY agonist|nmod|G-protein-coupled_receptor_55 G-protein-coupled_receptor_55|appos|END_ENTITY	BACKGROUND AND PURPOSE : The glycerol-based lysophospholipid lysophosphatidylinositol -LRB- LPI -RRB- is an endogenous agonist of the G-protein-coupled_receptor_55 -LRB- GPR55 -RRB- exhibiting cannabinoid receptor-like properties in endothelial cells .
23565223	0	lysophosphatidylinositol	40,64	GPR55	0,5	lysophosphatidylinositol	GPR55	MESH:C025449	227326(Tax:10090)	Chemical	Gene	receptor|nmod|START_ENTITY END_ENTITY|appos|receptor	GPR55 , a G-protein coupled receptor for lysophosphatidylinositol , plays a role in motor coordination .
23714700	0	lysophosphatidylinositol	30,54	GPR55	82,87	lysophosphatidylinositol	GPR55	MESH:C025449	9290	Chemical	Gene	actions|nmod|START_ENTITY actions|appos|agonist agonist|nmod|END_ENTITY	The actions and metabolism of lysophosphatidylinositol , an endogenous agonist for GPR55 .
22343749	0	lysophosphatidylserine	24,46	GPR34	0,5	lysophosphatidylserine	GPR34	MESH:C025059	2857	Chemical	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	GPR34 is a receptor for lysophosphatidylserine with a fatty_acid at the sn-2 position .
4027086	0	lysophospholipid	104,120	phospholipase_A	19,34	lysophospholipid	phospholipase A	CHEBI:16961	288025(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|activities activities|nmod|END_ENTITY	-LSB- The activities of phospholipase_A , PI-specific phospholipase C , lipase , lysophospholipase and acylCoA : lysophospholipid acyltransferase in ischemic brain microsomal fraction -RSB- .
22661479	0	lysyl	17,22	LOX	32,35	lysyl	LOX	CHEBI:32568	4015	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Variation in the lysyl oxidase -LRB- LOX -RRB- gene is associated with keratoconus in family-based and case-control studies .
11157981	0	lysyl	28,33	PLOD	47,51	lysyl	PLOD	CHEBI:32568	5351	Chemical	Gene	hydroxylase|amod|START_ENTITY hydroxylase|appos|END_ENTITY	PITX2 regulates procollagen lysyl hydroxylase -LRB- PLOD -RRB- gene expression : implications for the pathology of Rieger_syndrome .
7713497	0	lysyl	38,43	PLOD	62,66	lysyl	PLOD	CHEBI:32568	5351	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Structure and expression of the human lysyl hydroxylase gene -LRB- PLOD -RRB- : introns 9 and 16 contain Alu sequences at the sites of recombination in Ehlers-Danlos_syndrome type VI patients .
3110143	0	lysyl	20,25	antithrombin	37,49	lysyl	antithrombin	CHEBI:32568	462	Chemical	Gene	residue|amod|START_ENTITY residue|nmod|END_ENTITY	Identification of a lysyl residue in antithrombin which is essential for heparin binding .
21552961	0	lysyl	168,173	ha-ras	139,145	lysyl	ha-ras	CHEBI:32568	15461(Tax:10090)	Chemical	Gene	oxidase|compound|START_ENTITY oxidase|amod|END_ENTITY	Transcriptional switching model for the regulation of tumorigenesis and metastasis by the ha-ras oncogene - transcriptional changes in the ha-ras tumor-suppressor gene lysyl oxidase .
9582318	0	lysyl	91,96	lysyl_hydroxylase_3	110,129	lysyl	lysyl hydroxylase 3	CHEBI:32568	8985	Chemical	Gene	hydroxylase|amod|START_ENTITY hydroxylase|appos|END_ENTITY	Primary structure , tissue distribution , and chromosomal localization of a novel isoform of lysyl hydroxylase -LRB- lysyl_hydroxylase_3 -RRB- We report characterization of a novel isoform of lysyl hydroxylase -LRB- lysyl_hydroxylase_3 , LH3 -RRB- .
6119107	0	lysyl	23,28	myosin	40,46	lysyl	myosin	CHEBI:32568	79784	Chemical	Gene	residue|amod|START_ENTITY residue|nmod|END_ENTITY	Ionization of reactive lysyl residue to myosin subfragment 1 .
2453360	0	lysyl	64,69	phosphoenolpyruvate_carboxylase	82,113	lysyl	phosphoenolpyruvate carboxylase	CHEBI:32568	100101511(Tax:4577)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Proximity between fluorescent probes attached to four essential lysyl residues in phosphoenolpyruvate_carboxylase .
7759476	0	lysyl	16,21	tissue-type_plasminogen_activator	38,71	lysyl	tissue-type plasminogen activator	CHEBI:32568	5327	Chemical	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	The role of the lysyl binding site of tissue-type_plasminogen_activator in the interaction with a forming fibrin clot .
30449	1	lysyl	94,99	tropoelastin	118,130	lysyl	tropoelastin	CHEBI:32568	2006	Chemical	Gene	action|amod|START_ENTITY action|nmod|END_ENTITY	Studies on factors influencing the formation of desmosines by lysyl oxidase action on tropoelastin .
8856697	0	m-Chlorophenylpiperazine	0,24	5-HT2B_receptor	69,84	m-Chlorophenylpiperazine	5-HT2B receptor	MESH:C015068	3357	Chemical	Gene	antagonist|nsubj|START_ENTITY antagonist|nmod|END_ENTITY	m-Chlorophenylpiperazine -LRB- mCPP -RRB- is an antagonist at the cloned human 5-HT2B_receptor .
8844415	0	m-aminophenylboronate	32,53	hepatic_lipase	14,28	m-aminophenylboronate	hepatic lipase	null	3990	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of hepatic_lipase by m-aminophenylboronate .
22033265	0	m-carboxycinnamic_acid_bis-hydroxamide	30,68	plasminogen_activator_inhibitor-1	80,113	m-carboxycinnamic acid bis-hydroxamide	plasminogen activator inhibitor-1	MESH:C111238	5054	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|amod|END_ENTITY	Histone_deacetylase inhibitor m-carboxycinnamic_acid_bis-hydroxamide attenuates plasminogen_activator_inhibitor-1 expression in human pleural mesothelial cells .
18487257	0	m-chlorophenylpiperazine	34,58	5-HT2C	19,25	m-chlorophenylpiperazine	5-HT2C	MESH:C015068	3358	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|agonist agonist|nummod|END_ENTITY	The effects of the 5-HT2C agonist m-chlorophenylpiperazine on elite athletes with unexplained underperformance syndrome -LRB- overtraining -RRB- .
1410142	0	m-chlorophenylpiperazine	10,34	arginine-vasopressin	45,65	m-chlorophenylpiperazine	arginine-vasopressin	MESH:C015068	551	Chemical	Gene	concentrations|amod|START_ENTITY concentrations|amod|END_ENTITY	Effect of m-chlorophenylpiperazine on plasma arginine-vasopressin concentrations in healthy subjects .
16158247	0	m475271	31,38	SRC	0,3	m475271	SRC	MESH:C503850	6714	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	SRC tyrosine kinase inhibitor , m475271 , suppresses subcutaneous growth and production of lung metastasis via inhibition of proliferation , invasion , and vascularization of human lung_adenocarcinoma cells .
18357975	0	macbecin	30,38	Hsp90	45,50	macbecin	Hsp90	null	111058(Tax:10090)	Chemical	Gene	characterization|nmod|START_ENTITY characterization|nmod|inhibitor inhibitor|amod|END_ENTITY	Molecular characterization of macbecin as an Hsp90 inhibitor .
24931917	0	machine	12,19	CO2	21,24	machine	CO2	null	717	Chemical	Gene	START_ENTITY|dep|activation activation|compound|END_ENTITY	The bending machine : CO2 activation and hydrogenation on - MoC -LRB- 001 -RRB- and b-Mo2C -LRB- 001 -RRB- surfaces .
17482814	0	macrocyclic_tertiary_carbinamine	30,62	BACE-1	63,69	macrocyclic tertiary carbinamine	BACE-1	null	23621	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Design , synthesis , and SAR of macrocyclic_tertiary_carbinamine BACE-1 inhibitors .
17827011	0	macrocyclic_tertiary_carbinamine	53,85	BACE-1	86,92	macrocyclic tertiary carbinamine	BACE-1	null	23621	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Strategies toward improving the brain penetration of macrocyclic_tertiary_carbinamine BACE-1 inhibitors .
20621639	0	macrolide	29,38	MDR1	62,66	macrolide	MDR1	CHEBI:25106	5243	Chemical	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	Differences in assessment of macrolide interaction with human MDR1 -LRB- ABCB1 , P-gp -RRB- using rhodamine-123 efflux , ATPase activity and cellular accumulation assays .
24868216	0	macrolides	54,64	C-reactive_protein	20,38	macrolides	C-reactive protein	MESH:D018942	1401	Chemical	Gene	value|nmod|START_ENTITY value|nmod|END_ENTITY	Predictive value of C-reactive_protein in response to macrolides in children with macrolide-resistant Mycoplasma_pneumoniae pneumonia .
8797304	0	macrolides	11,21	cytokine	25,33	macrolides	cytokine	MESH:D018942	943	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effect of macrolides on cytokine mRNA expression in human whole blood model -RSB- .
10867834	0	macrolides	11,21	interleukin-8	25,38	macrolides	interleukin-8	MESH:D018942	3576	Chemical	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	Effects of macrolides on interleukin-8 secretion from human nasal epithelial cells .
9396683	0	macrolides	21,31	interleukin-8	35,48	macrolides	interleukin-8	MESH:D018942	3576	Chemical	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	Inhibitory effect of macrolides on interleukin-8 secretion from cultured human nasal epithelial cells .
16319604	0	macrolides	52,62	vascular_endothelial_growth_factor	14,48	macrolides	vascular endothelial growth factor	MESH:D018942	7422	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of vascular_endothelial_growth_factor by macrolides in cultured fibroblasts from nasal polyps .
15539023	0	madecassoside	11,24	MAO	74,77	madecassoside	MAO	MESH:C093443	29253(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of madecassoside on depression behavior of mice and activities of MAO in different brain regions of rats -RSB- .
2108114	0	mafenide	14,22	dihydropteroate_synthase	26,50	mafenide	dihydropteroate synthase	MESH:D008272	20491868	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of mafenide on dihydropteroate_synthase .
21276780	0	magnesium	53,62	ALDH2	71,76	magnesium	ALDH2	MESH:D008274	217	Chemical	Gene	ions|compound|START_ENTITY ions|nmod|END_ENTITY	NADH fluorescence lifetime analysis of the effect of magnesium ions on ALDH2 .
136270	0	magnesium	43,52	ATPase	81,87	magnesium	ATPase	MESH:D008274	1769	Chemical	Gene	interaction|nmod|START_ENTITY studies|nmod|interaction studies|nmod|+ +|appos|END_ENTITY	Calorimetric studies of the interaction of magnesium and phosphate with Na + , K + -RRB- ATPase : evidence for a ligand-induced conformational change in the enzyme .
142160	0	magnesium	8,17	ATPase	59,65	magnesium	ATPase	MESH:D008274	1769	Chemical	Gene	Role|nmod|START_ENTITY Role|dep|END_ENTITY	Role of magnesium in the -LRB- Ca2 + + Mg2 + -RRB- - stimulated membrane ATPase of human red blood cells .
16928192	0	magnesium	36,45	ATPase	0,6	magnesium	ATPase	MESH:D008274	3654511(Tax:562)	Chemical	Gene	H-subunit|compound|START_ENTITY associated|nmod|H-subunit activity|acl|associated activity|amod|END_ENTITY	ATPase activity associated with the magnesium chelatase H-subunit of the chlorophyll biosynthetic pathway is an artefact .
24253726	0	magnesium	10,19	ATPase	31,37	magnesium	ATPase	MESH:D008274	1769	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of magnesium and ATP on ATPase of sugarcane vacuoles .
4223061	0	magnesium	89,98	ATPase	67,73	magnesium	ATPase	MESH:D008274	1769	Chemical	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	The allosteric nature of substrate inhibition of insect actomyosin ATPase in presence of magnesium .
6259330	0	magnesium	7,16	ATPase	54,60	magnesium	ATPase	MESH:D008274	1769	Chemical	Gene	converts|nsubj|START_ENTITY converts|xcomp|END_ENTITY	Excess magnesium converts red cell -LRB- sodium + potassium -RRB- ATPase to the potassium phosphatase .
6313060	0	magnesium	33,42	ATPase	23,29	magnesium	ATPase	MESH:D008274	1769	Chemical	Gene	ions|compound|START_ENTITY END_ENTITY|nmod|ions	Inhibition of -LRB- Na + , K + -RRB- - ATPase by magnesium ions and inorganic phosphate and release of these ligands in the cycles of ATP hydrolysis .
7833352	0	magnesium	39,48	ATPase	72,78	magnesium	ATPase	MESH:D008274	1769	Chemical	Gene	distinguish|dobj|START_ENTITY analysis|acl|distinguish Use|nmod|analysis stimulated|nsubj|Use stimulated|dobj|activity activity|amod|END_ENTITY	Use of thermal analysis to distinguish magnesium and calcium stimulated ATPase activity in isolated transverse tubules from skeletal muscle .
17101715	0	magnesium	33,42	AtMGT1	59,65	magnesium	AtMGT1	MESH:D008274	844430(Tax:3702)	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Overexpression of an Arabidopsis magnesium transport gene , AtMGT1 , in Nicotiana benthamiana confers Al tolerance .
19711039	0	magnesium	55,64	Basic_fibroblast_growth_factor	0,30	magnesium	Basic fibroblast growth factor	MESH:D008274	2247	Chemical	Gene	concentration|compound|START_ENTITY increases|dobj|concentration increases|nsubj|END_ENTITY	Basic_fibroblast_growth_factor increases intracellular magnesium concentration through the specific signaling pathways .
21714500	0	magnesium	20,29	Cdc31	54,59	magnesium	Cdc31	MESH:D008274	854431(Tax:4932)	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of calcium , magnesium , and target peptides to Cdc31 , the centrin of yeast Saccharomyces_cerevisiae .
20719712	0	magnesium	35,44	HD-PTP	19,25	magnesium	HD-PTP	MESH:D008274	25930	Chemical	Gene	concentration|compound|START_ENTITY END_ENTITY|nmod|concentration	Downregulation of HD-PTP by high magnesium concentration : novel insights into magnesium-induced endothelial migration .
15539200	0	magnesium	71,80	Insulin	0,7	magnesium	Insulin	MESH:D008274	105613195	Chemical	Gene	fed|dobj|START_ENTITY fed|nsubj|secretion secretion|compound|END_ENTITY	Insulin secretion and glucose_uptake in hypomagnesemic sheep fed a low magnesium , high potassium diet .
17003272	0	magnesium	59,68	Insulin	0,7	magnesium	Insulin	MESH:D008274	3630	Chemical	Gene	variations|compound|START_ENTITY ionized|dobj|variations ionized|nsubj|END_ENTITY	Insulin and glucose mediate opposite intracellular ionized magnesium variations in human lymphocytes .
3539681	0	magnesium	59,68	Insulin	0,7	magnesium	Insulin	MESH:D008274	3630	Chemical	Gene	concentrations|compound|START_ENTITY changes|nmod|concentrations induces|dobj|changes induces|nsubj|END_ENTITY	Insulin induces opposite changes in plasma and erythrocyte magnesium concentrations in normal man .
7587003	0	magnesium	24,33	Insulin	0,7	magnesium	Insulin	MESH:D008274	3630	Chemical	Gene	excretion|compound|START_ENTITY increases|dobj|excretion increases|nsubj|END_ENTITY	Insulin increases renal magnesium excretion : a possible cause of magnesium depletion in hyperinsulinaemic states .
7587003	0	magnesium	65,74	Insulin	0,7	magnesium	Insulin	MESH:D008274	3630	Chemical	Gene	depletion|compound|START_ENTITY cause|nmod|depletion excretion|dep|cause increases|dobj|excretion increases|nsubj|END_ENTITY	Insulin increases renal magnesium excretion : a possible cause of magnesium depletion in hyperinsulinaemic states .
8445010	0	magnesium	32,41	Insulin	0,7	magnesium	Insulin	MESH:D008274	3630	Chemical	Gene	transport|compound|START_ENTITY increases|dobj|transport increases|nsubj|END_ENTITY	Insulin increases intracellular magnesium transport in human platelets .
11254124	0	magnesium	88,97	Lpe10p	41,47	magnesium	Lpe10p	MESH:D008274	856045(Tax:4932)	Chemical	Gene	homeostasis|compound|START_ENTITY essential|nmod|homeostasis essential|nsubj|END_ENTITY	The mitochondrial inner membrane protein Lpe10p , a homologue of Mrs2p , is essential for magnesium homeostasis and group II intron splicing in yeast .
19717468	0	magnesium	52,61	MagT1	10,15	magnesium	MagT1	MESH:D008274	84061	Chemical	Gene	uptake|compound|START_ENTITY required|nmod|uptake required|nsubjpass|END_ENTITY	Mammalian MagT1 and TUSC3 are required for cellular magnesium uptake and vertebrate embryonic development .
21947671	0	magnesium	25,34	MagT1	0,5	magnesium	MagT1	MESH:D008274	84061	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|dep|channel	MagT1 : a highly specific magnesium channel with important roles beyond cellular magnesium homeostasis .
21947671	0	magnesium	80,89	MagT1	0,5	magnesium	MagT1	MESH:D008274	84061	Chemical	Gene	homeostasis|compound|START_ENTITY roles|nmod|homeostasis channel|nmod|roles END_ENTITY|dep|channel	MagT1 : a highly specific magnesium channel with important roles beyond cellular magnesium homeostasis .
8173140	1	magnesium	175,184	Mg2	186,189	magnesium	Mg2	MESH:D008274	4589	Chemical	Gene	START_ENTITY|appos|+ +|compound|END_ENTITY	OBJECTIVE : To review the methods and summarize the findings of clinical trials evaluating the use of intravenous magnesium -LRB- Mg2 + -RRB- in acute_myocardial_infarction -LRB- AMI -RRB- ; to discuss serum Mg2 + in AMI and the potential mechanisms by which intravenous Mg2 + may be effective .
11401429	0	magnesium	99,108	Mrs2	24,28	magnesium	Mrs2	MESH:D008274	57380	Chemical	Gene	transporter|compound|START_ENTITY homologue|appos|transporter substitutes|nmod|homologue protein|dep|substitutes protein|amod|END_ENTITY	The human mitochondrial Mrs2 protein functionally substitutes for its yeast homologue , a candidate magnesium transporter .
20516593	0	magnesium	95,104	Mrs2	87,91	magnesium	Mrs2	MESH:D008274	854511(Tax:4932)	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|appos|transporter	Crystallization and preliminary X-ray diffraction analysis of the N-terminal domain of Mrs2 , a magnesium ion transporter from yeast inner mitochondrial membrane .
14516451	0	magnesium	59,68	RANTES	101,107	magnesium	RANTES	MESH:D008274	6352	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|release release|nmod|END_ENTITY	Storage of platelets in additive solutions : the effects of magnesium and potassium on the release of RANTES , beta-thromboglobulin , platelet_factor_4 and interleukin-7 , during storage .
16075242	0	magnesium	39,48	TRPM6	19,24	magnesium	TRPM6	MESH:D008274	140803	Chemical	Gene	transport|compound|START_ENTITY role|nmod|transport role|nmod|END_ENTITY	Essential role for TRPM6 in epithelial magnesium transport and body magnesium homeostasis .
16075242	0	magnesium	39,48	TRPM6	19,24	magnesium	TRPM6	MESH:D008274	140803	Chemical	Gene	transport|compound|START_ENTITY role|nmod|transport role|nmod|END_ENTITY	Essential role for TRPM6 in epithelial magnesium transport and body magnesium homeostasis .
22180838	0	magnesium	56,65	TRPM6	77,82	magnesium	TRPM6	MESH:D008274	140803	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Phosphatidylinositol_4 ,5 - bisphosphate -LRB- PIP -LRB- 2 -RRB- -RRB- controls magnesium gatekeeper TRPM6 activity .
22180838	0	magnesium	56,65	TRPM6	77,82	magnesium	TRPM6	MESH:D008274	140803	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Phosphatidylinositol_4 ,5 - bisphosphate -LRB- PIP -LRB- 2 -RRB- -RRB- controls magnesium gatekeeper TRPM6 activity .
15150423	0	magnesium	41,50	TRPM7	0,5	magnesium	TRPM7	MESH:D008274	54822	Chemical	Gene	homeostasis|compound|START_ENTITY future|nmod|homeostasis channeling|dobj|future END_ENTITY|parataxis|channeling	TRPM7 : channeling the future of cellular magnesium homeostasis ?
15150423	0	magnesium	41,50	TRPM7	0,5	magnesium	TRPM7	MESH:D008274	54822	Chemical	Gene	homeostasis|compound|START_ENTITY future|nmod|homeostasis channeling|dobj|future END_ENTITY|parataxis|channeling	TRPM7 : channeling the future of cellular magnesium homeostasis ?
16051700	0	magnesium	45,54	TRPM7	2,7	magnesium	TRPM7	MESH:D008274	54822	Chemical	Gene	shows|nmod|START_ENTITY shows|nsubj|variant variant|compound|END_ENTITY	A TRPM7 variant shows altered sensitivity to magnesium that may contribute to the pathogenesis of two Guamanian_neurodegenerative_disorders .
16051700	0	magnesium	45,54	TRPM7	2,7	magnesium	TRPM7	MESH:D008274	54822	Chemical	Gene	shows|nmod|START_ENTITY shows|nsubj|variant variant|compound|END_ENTITY	A TRPM7 variant shows altered sensitivity to magnesium that may contribute to the pathogenesis of two Guamanian_neurodegenerative_disorders .
16258415	0	magnesium	34,43	TRPM7	1,6	magnesium	TRPM7	MESH:D008274	54822	Chemical	Gene	homeostasis|compound|START_ENTITY responsible|nmod|homeostasis protein|amod|responsible END_ENTITY|dep|protein	-LSB- TRPM7 : a protein responsible for magnesium homeostasis in a cell -RSB- .
18268139	0	magnesium	110,119	TRPM7	24,29	magnesium	TRPM7	MESH:D008274	58800(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY Downregulation|dep|effects Downregulation|nmod|END_ENTITY	Downregulation of renal TRPM7 and increased inflammation and fibrosis in aldosterone-infused mice : effects of magnesium .
20696983	0	magnesium	100,109	TRPM7	80,85	magnesium	TRPM7	MESH:D008274	58800(Tax:10090)	Chemical	Gene	involves|nmod|START_ENTITY involves|dobj|modulation modulation|compound|END_ENTITY	Vascular smooth muscle cell differentiation to an osteogenic phenotype involves TRPM7 modulation by magnesium .
21487014	0	magnesium	45,54	TRPM7	102,107	magnesium	TRPM7	MESH:D008274	679906(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|channels channels|appos|END_ENTITY	Hypoxia induces an increase in intracellular magnesium via transient_receptor_potential_melastatin_7 -LRB- TRPM7 -RRB- channels in rat hippocampal neurons in vitro .
21487014	0	magnesium	45,54	TRPM7	102,107	magnesium	TRPM7	MESH:D008274	679906(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|channels channels|appos|END_ENTITY	Hypoxia induces an increase in intracellular magnesium via transient_receptor_potential_melastatin_7 -LRB- TRPM7 -RRB- channels in rat hippocampal neurons in vitro .
22634382	0	magnesium	36,45	TRPM7	0,5	magnesium	TRPM7	MESH:D008274	54822	Chemical	Gene	homeostasis|compound|START_ENTITY involved|nmod|homeostasis channel|acl|involved END_ENTITY|dep|channel	TRPM7 : a unique channel involved in magnesium homeostasis .
22634382	0	magnesium	36,45	TRPM7	0,5	magnesium	TRPM7	MESH:D008274	54822	Chemical	Gene	homeostasis|compound|START_ENTITY involved|nmod|homeostasis channel|acl|involved END_ENTITY|dep|channel	TRPM7 : a unique channel involved in magnesium homeostasis .
24556627	0	magnesium	18,27	TRPM7	52,57	magnesium	TRPM7	MESH:D008274	54822	Chemical	Gene	transporters|compound|START_ENTITY magnesium|nmod|transporters END_ENTITY|nmod|magnesium	From magnesium to magnesium transporters in cancer : TRPM7 , a novel signature in tumour development .
24824683	0	magnesium	96,105	TRPM7	12,17	magnesium	TRPM7	MESH:D008274	54822	Chemical	Gene	deficiency|compound|START_ENTITY Patterns|nmod|deficiency Patterns|nmod|expression expression|nummod|END_ENTITY	Patterns of TRPM7 expression in hypothalamic and hippocampal neurons in modeling of nutritional magnesium deficiency .
25326319	0	magnesium	65,74	TRPM7	59,64	magnesium	TRPM7	MESH:D008274	54822	Chemical	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	Identification of a Mg2 + - sensitive ORF in the 5 ' - leader of TRPM7 magnesium channel mRNA .
25534891	0	magnesium	83,92	TRPM7	28,33	magnesium	TRPM7	MESH:D008274	58800(Tax:10090)	Chemical	Gene	leads|xcomp|START_ENTITY Elucidating|parataxis|leads Elucidating|dobj|role role|nmod|alpha-kinase alpha-kinase|compound|END_ENTITY	Elucidating the role of the TRPM7 alpha-kinase : TRPM7 kinase inactivation leads to magnesium deprivation resistance phenotype in mice .
25534891	0	magnesium	83,92	TRPM7	48,53	magnesium	TRPM7	MESH:D008274	58800(Tax:10090)	Chemical	Gene	leads|xcomp|START_ENTITY leads|nsubj|inactivation inactivation|nummod|END_ENTITY	Elucidating the role of the TRPM7 alpha-kinase : TRPM7 kinase inactivation leads to magnesium deprivation resistance phenotype in mice .
16828056	0	magnesium	63,72	Vascular_endothelial_growth_factor	0,34	magnesium	Vascular endothelial growth factor	MESH:D008274	7422	Chemical	Gene	increases|dobj|START_ENTITY increases|nsubj|END_ENTITY	Vascular_endothelial_growth_factor increases the intracellular magnesium .
1939521	0	magnesium	29,38	and_1	82,87	magnesium	and 1	MESH:D008274	11169	Chemical	Gene	depletion|compound|START_ENTITY depletion|nmod|END_ENTITY	Effect of experimental human magnesium depletion on parathyroid_hormone secretion and_1 ,25 - dihydroxyvitamin_D metabolism .
1835306	0	magnesium	18,27	atrial_natriuretic_peptide	31,57	magnesium	atrial natriuretic peptide	MESH:D008274	24602(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|release release|amod|END_ENTITY	Effect of dietary magnesium on atrial_natriuretic_peptide release .
14516451	0	magnesium	59,68	beta-thromboglobulin	109,129	magnesium	beta-thromboglobulin	MESH:D008274	5473	Chemical	Gene	effects|nmod|START_ENTITY effects|amod|END_ENTITY	Storage of platelets in additive solutions : the effects of magnesium and potassium on the release of RANTES , beta-thromboglobulin , platelet_factor_4 and interleukin-7 , during storage .
17442678	0	magnesium	66,75	claudin-16	29,39	magnesium	claudin-16	MESH:D008274	114141(Tax:10090)	Chemical	Gene	depletion|nmod|START_ENTITY depletion|nmod|END_ENTITY	Transgenic RNAi depletion of claudin-16 and the renal handling of magnesium .
17976367	0	magnesium	61,70	claudin-16	85,95	magnesium	claudin-16	MESH:D008274	608218(Tax:9615)	Chemical	Gene	transport|compound|START_ENTITY transport|nmod|END_ENTITY	Activation of a polyvalent cation-sensing_receptor decreases magnesium transport via claudin-16 .
18698248	0	magnesium	28,37	cyclosporine_A	10,24	magnesium	cyclosporine A	MESH:D008274	71991(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY END_ENTITY|nmod|homeostasis	Impact of cyclosporine_A on magnesium homeostasis : clinical observation in lung transplant recipients and experimental study in mice .
12827022	0	magnesium	10,19	endothelin-1	57,69	magnesium	endothelin-1	MESH:D008274	24323(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of magnesium on mRNA expression and production of endothelin-1 in DOCA-salt hypertensive rats .
11153893	0	magnesium	10,19	fibrinogen	74,84	magnesium	fibrinogen	MESH:D008274	2244	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of magnesium on fibrin formation from lower molecular weight -LRB- LMW -RRB- fibrinogen .
20635860	0	magnesium	11,20	furin	47,52	magnesium	furin	MESH:D008274	5045	Chemical	Gene	ions|compound|START_ENTITY ions|nmod|END_ENTITY	Effects of magnesium ions on recombinant human furin : selective activation of hydrolytic activity upon substrates derived from virus envelope_glycoprotein .
10636912	0	magnesium	16,25	hMSH6	42,47	magnesium	hMSH6	MESH:D008274	2956	Chemical	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Mutation in the magnesium binding site of hMSH6 disables the hMutSalpha sliding clamp from translocating along DNA .
10480466	0	magnesium	12,21	insulin	41,48	magnesium	insulin	MESH:D008274	3630	Chemical	Gene	associated|nsubjpass|START_ENTITY associated|nmod|resistance resistance|compound|END_ENTITY	Low dietary magnesium is associated with insulin resistance in a sample of young , nondiabetic Black Americans .
11311848	0	magnesium	100,109	insulin	71,78	magnesium	insulin	MESH:D008274	105613195	Chemical	Gene	given|dobj|START_ENTITY Effect|acl|given Effect|nmod|END_ENTITY	Effect of hypomagnesemia and cold exposure on tissue responsiveness to insulin in sheep given a low magnesium and high potassium diet .
12511185	0	magnesium	5,14	insulin	60,67	magnesium	insulin	MESH:D008274	3630	Chemical	Gene	dysbalance|compound|START_ENTITY participate|nsubj|dysbalance participate|nmod|development development|nmod|resistance resistance|compound|END_ENTITY	Does magnesium dysbalance participate in the development of insulin resistance in early stages of renal_disease ?
14693967	0	magnesium	8,17	insulin	47,54	magnesium	insulin	MESH:D008274	3630	Chemical	Gene	intake|compound|START_ENTITY intake|nmod|relation relation|nmod|levels levels|compound|END_ENTITY	Dietary magnesium intake in relation to plasma insulin levels and risk of type 2 diabetes in women .
19124169	0	magnesium	24,33	insulin	112,119	magnesium	insulin	MESH:D008274	3630	Chemical	Gene	deficiency|compound|START_ENTITY deficiency|dep|evidences evidences|nmod|relation relation|nmod|resistance resistance|compound|END_ENTITY	Serum and intracellular magnesium deficiency in patients with metabolic_syndrome -- evidences for its relation to insulin resistance .
20531272	0	magnesium	27,36	insulin	56,63	magnesium	insulin	MESH:D008274	3630	Chemical	Gene	effects|nmod|START_ENTITY supplementation|nsubj|effects supplementation|nmod|sensitivity sensitivity|compound|END_ENTITY	Beneficial effects of oral magnesium supplementation on insulin sensitivity and serum lipid profile .
21205110	0	magnesium	5,14	insulin	39,46	magnesium	insulin	MESH:D008274	3630	Chemical	Gene	supplementation|compound|START_ENTITY reduces|nsubj|supplementation reduces|dobj|resistance resistance|compound|END_ENTITY	Oral magnesium supplementation reduces insulin resistance in non-diabetic subjects - a double-blind , placebo-controlled , randomized trial .
21696337	0	magnesium	6,15	insulin	85,92	magnesium	insulin	MESH:D008274	3630	Chemical	Gene	concentrations|compound|START_ENTITY concentrations|nmod|resistance resistance|compound|END_ENTITY	Serum magnesium concentrations in polycystic_ovary_syndrome and its association with insulin resistance .
21821372	0	magnesium	59,68	insulin	74,81	magnesium	insulin	MESH:D008274	3630	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	The association of serum C-reactive_protein , uric_acid and magnesium with insulin resistance in Chinese postmenopausal women with prediabetes or early untreated diabetes .
23472169	0	magnesium	13,22	insulin	53,60	magnesium	insulin	MESH:D008274	3630	Chemical	Gene	intake|compound|START_ENTITY associated|nsubjpass|intake associated|nmod|resistance resistance|compound|END_ENTITY	High dietary magnesium intake is associated with low insulin resistance in the Newfoundland population .
24984789	0	magnesium	13,22	insulin	26,33	magnesium	insulin	MESH:D008274	3630	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|resistance resistance|compound|END_ENTITY	Influence of magnesium on insulin resistance in obese women .
3241201	0	magnesium	19,28	insulin	69,76	magnesium	insulin	MESH:D008274	3630	Chemical	Gene	START_ENTITY|dep|relation relation|nmod|resistance resistance|compound|END_ENTITY	Intracellular free magnesium in hypertension : relation to peripheral insulin resistance .
7714113	0	magnesium	29,38	insulin	95,102	magnesium	insulin	MESH:D008274	3630	Chemical	Gene	insulin|nmod|START_ENTITY Effects|nmod|insulin Effects|dep|evidence evidence|nmod|resistance resistance|compound|END_ENTITY	Effects of insulin on plasma magnesium in noninsulin-dependent_diabetes_mellitus : evidence for insulin resistance .
7783102	0	magnesium	47,56	insulin	138,145	magnesium	insulin	MESH:D008274	3630	Chemical	Gene	accumulation|compound|START_ENTITY accumulation|dep|role role|nmod|resistance resistance|compound|END_ENTITY	Low fasting and insulin-mediated intracellular magnesium accumulation in hypertensive patients with left_ventricular_hypertrophy : role of insulin resistance .
8206589	0	magnesium	8,17	insulin	44,51	magnesium	insulin	MESH:D008274	3630	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|dobj|insensitivity insensitivity|compound|END_ENTITY	Dietary magnesium prevents fructose-induced insulin insensitivity in rats .
1772874	0	magnesium	88,97	insulin-like_growth_factor-1	8,36	magnesium	insulin-like growth factor-1	MESH:D008274	24482(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Role Role|nmod|END_ENTITY	Role of insulin-like_growth_factor-1 and growth_hormone in growth inhibition induced by magnesium and zinc_deficiencies .
16911085	0	magnesium	35,44	leptin	19,25	magnesium	leptin	MESH:D008274	3952	Chemical	Gene	excretion|compound|START_ENTITY effect|nmod|excretion effect|nmod|END_ENTITY	Possible effect of leptin on renal magnesium excretion in adolescent patients with type 1 diabetes .
15221343	0	magnesium	11,20	matrix_metalloproteinase-2	24,50	magnesium	matrix metalloproteinase-2	MESH:D008274	81686(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|production production|amod|END_ENTITY	Effects of magnesium on matrix_metalloproteinase-2 production in cultured rat cardiac fibroblasts .
2145973	0	magnesium	28,37	myosin	110,116	magnesium	myosin	MESH:D008274	396902(Tax:9823)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of phosphorylation , magnesium , and filament assembly on actin-activated ATPase of pig urinary bladder myosin .
4282251	0	magnesium	14,23	myosin	42,48	magnesium	myosin	MESH:D008274	79784	Chemical	Gene	inhibition|compound|START_ENTITY Study|nmod|inhibition Study|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Study of the magnesium inhibition of the myosin ATPase reaction -RSB- .
6107126	0	magnesium	13,22	myosin	66,72	magnesium	myosin	MESH:D008274	79784	Chemical	Gene	ion-adenosine|compound|START_ENTITY triphosphatase|nsubj|ion-adenosine triphosphatase|dobj|activities activities|nmod|END_ENTITY	Steady-state magnesium ion-adenosine triphosphatase activities of myosin and its subfragment 1 derivative .
6873060	0	magnesium	12,21	myosin	93,99	magnesium	myosin	MESH:D008274	79784	Chemical	Gene	role|nmod|START_ENTITY role|nmod|subfragment-1 subfragment-1|compound|END_ENTITY	The role of magnesium in binding of the nucleotide_polyphosphate chain to the active site of myosin subfragment-1 .
7573390	0	magnesium	11,20	nitric_oxide_synthase	24,45	magnesium	nitric oxide synthase	MESH:D008274	4843	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|amod|END_ENTITY	Effects of magnesium on nitric_oxide_synthase activity in endothelial cells .
5654162	0	magnesium	10,19	oxytocin	37,45	magnesium	oxytocin	MESH:D008274	5020	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|action action|nmod|END_ENTITY	Effect of magnesium on the action of oxytocin and a group of analogues on the uterus in vitro .
10814601	0	magnesium	89,98	parathyroid_hormone	210,229	magnesium	parathyroid hormone	MESH:D008274	24694(Tax:10116)	Chemical	Gene	deficiency|compound|START_ENTITY Effects|dep|deficiency Effects|nmod|presence presence|nmod|D D|nmod|END_ENTITY	Effects of partial and total colectomy on mineral and acid-base homoeostasis in the rat : magnesium deficiency , hyperphosphaturia and osteopathy , in the presence of high serum 1,25-dihydroxyvitamin _ D but normal parathyroid_hormone .
11379859	0	magnesium	6,15	parathyroid_hormone	61,80	magnesium	parathyroid hormone	MESH:D008274	5741	Chemical	Gene	concentration|compound|START_ENTITY predictor|nsubj|concentration predictor|nmod|levels levels|amod|END_ENTITY	Serum magnesium concentration is an independent predictor of parathyroid_hormone levels in peritoneal dialysis patients .
1248443	0	magnesium	26,35	parathyroid_hormone	85,104	magnesium	parathyroid hormone	MESH:D008274	280903(Tax:9913)	Chemical	Gene	effectiveness|nmod|START_ENTITY effectiveness|nmod|END_ENTITY	Relative effectiveness of magnesium and calcium on the secretion and biosynthesis of parathyroid_hormone in vitro .
12495258	0	magnesium	58,67	parathyroid_hormone	71,90	magnesium	parathyroid hormone	MESH:D008274	5741	Chemical	Gene	milk|nmod|START_ENTITY Impact|nmod|milk Impact|nmod|markers markers|amod|END_ENTITY	Impact of supplementary high calcium milk with additional magnesium on parathyroid_hormone and biochemical markers of bone turnover in postmenopausal women .
1591141	0	magnesium	123,132	parathyroid_hormone	57,76	magnesium	parathyroid hormone	MESH:D008274	5741	Chemical	Gene	replenishment|compound|START_ENTITY dihydroxyvitamin_D|nmod|replenishment dihydroxyvitamin_D|nsubj|hypocalcaemia hypocalcaemia|dep|concentrations concentrations|nmod|END_ENTITY	Hypomagnesaemia-induced hypocalcaemia : concentrations of parathyroid_hormone , prolactin and_1 ,25 - dihydroxyvitamin_D during magnesium replenishment .
16536717	0	magnesium	35,44	parathyroid_hormone	67,86	magnesium	parathyroid hormone	MESH:D008274	5741	Chemical	Gene	START_ENTITY|acl|induced induced|dobj|inhibition inhibition|nmod|secretion secretion|amod|END_ENTITY	An unusual cause of hypocalcaemia : magnesium induced inhibition of parathyroid_hormone secretion in a patient with subarachnoid_haemorrhage .
177448	0	magnesium	43,52	parathyroid_hormone	20,39	magnesium	parathyroid hormone	MESH:D008274	5741	Chemical	Gene	deficiency|compound|START_ENTITY release|nmod|deficiency release|nmod|END_ENTITY	Impaired release of parathyroid_hormone in magnesium deficiency .
182417	0	magnesium	84,93	parathyroid_hormone	34,53	magnesium	parathyroid hormone	MESH:D008274	5741	Chemical	Gene	deficiency|compound|START_ENTITY END_ENTITY|nmod|deficiency	Functional hypoparathyroidism and parathyroid_hormone end-organ resistance in human magnesium deficiency .
1939521	0	magnesium	29,38	parathyroid_hormone	52,71	magnesium	parathyroid hormone	MESH:D008274	5741	Chemical	Gene	depletion|compound|START_ENTITY depletion|nmod|and_1 and_1|amod|END_ENTITY	Effect of experimental human magnesium depletion on parathyroid_hormone secretion and_1 ,25 - dihydroxyvitamin_D metabolism .
20810356	0	magnesium	8,17	parathyroid_hormone	79,98	magnesium	parathyroid hormone	MESH:D008274	24694(Tax:10116)	Chemical	Gene	supplementation|compound|START_ENTITY suppresses|nsubj|supplementation suppresses|dobj|resorption resorption|nmod|inhibition inhibition|nmod|secretion secretion|amod|END_ENTITY	Dietary magnesium supplementation suppresses bone resorption via inhibition of parathyroid_hormone secretion in rats fed a high-phosphorus diet .
2132084	0	magnesium	13,22	parathyroid_hormone	42,61	magnesium	parathyroid hormone	MESH:D008274	24694(Tax:10116)	Chemical	Gene	supplementation|compound|START_ENTITY Influence|nmod|supplementation Influence|nmod|concentration concentration|compound|END_ENTITY	Influence of magnesium supplementation on parathyroid_hormone and bone_Gla_protein concentration in normal rats .
231063	0	magnesium	13,22	parathyroid_hormone	54,73	magnesium	parathyroid hormone	MESH:D008274	5741	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|secretion secretion|nmod|END_ENTITY	Influence of magnesium on the secretion and action of parathyroid_hormone .
26671274	0	magnesium	39,48	parathyroid_hormone	10,29	magnesium	parathyroid hormone	MESH:D008274	5741	Chemical	Gene	levels|compound|START_ENTITY END_ENTITY|nmod|levels	Effect of parathyroid_hormone on serum magnesium levels : the neglected relationship in hemodialysis patients with secondary_hyperparathyroidism .
3585222	0	magnesium	37,46	parathyroid_hormone	62,81	magnesium	parathyroid hormone	MESH:D008274	5741	Chemical	Gene	effect|nmod|START_ENTITY Comparison|nmod|effect Comparison|nmod|secretion secretion|amod|END_ENTITY	Comparison of the feedback effect of magnesium and calcium on parathyroid_hormone secretion in man .
4335446	0	magnesium	10,19	parathyroid_hormone	51,70	magnesium	parathyroid hormone	MESH:D008274	24694(Tax:10116)	Chemical	Gene	depletion|compound|START_ENTITY Effect|nmod|depletion responsiveness|nsubj|Effect responsiveness|xcomp|END_ENTITY	Effect of magnesium depletion on responsiveness to parathyroid_hormone in parathyroidectomized rats .
4476593	0	magnesium	108,117	parathyroid_hormone	27,46	magnesium	parathyroid hormone	MESH:D008274	5741	Chemical	Gene	ion|compound|START_ENTITY effects|nmod|ion cyclase|nmod|effects -RSB-|amod|cyclase -RSB-|amod|END_ENTITY	-LSB- Proceedings : Secretion of parathyroid_hormone and adenyl cyclase -- with special reference to the effects of magnesium ion -RSB- .
6775789	0	magnesium	11,20	parathyroid_hormone	28,47	magnesium	parathyroid hormone	MESH:D008274	280903(Tax:9913)	Chemical	Gene	Effects|nmod|START_ENTITY ion|nsubj|Effects ion|nmod|secretion secretion|amod|END_ENTITY	Effects of magnesium ion on parathyroid_hormone secretion in vitro .
7187765	0	magnesium	85,94	parathyroid_hormone	17,36	magnesium	parathyroid hormone	MESH:D008274	101120013	Chemical	Gene	phosphorus|compound|START_ENTITY influence|nmod|phosphorus influence|nmod|END_ENTITY	The influence of parathyroid_hormone and calcitonin on urinary excretion of calcium , magnesium and inorganic phosphorus in chronically catheterized foetal lambs in utero .
7191964	0	magnesium	77,86	parathyroid_hormone	10,29	magnesium	parathyroid hormone	MESH:D008274	24694(Tax:10116)	Chemical	Gene	calcium|nmod|START_ENTITY END_ENTITY|nmod|calcium	Effect of parathyroid_hormone on renal calcium and magnesium reabsorption in magnesium deficient_rats .
7386116	0	magnesium	43,52	parathyroid_hormone	68,87	magnesium	parathyroid hormone	MESH:D008274	5741	Chemical	Gene	lowering|dobj|START_ENTITY lowering|advcl|circulating circulating|dobj|therapy therapy|amod|END_ENTITY	The long-term effect of lowering dialysate magnesium on circulating parathyroid_hormone in patients on regular haemodialysis therapy .
7400850	0	magnesium	10,19	parathyroid_hormone	69,88	magnesium	parathyroid hormone	MESH:D008274	24694(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY deficiency_on_rat_bone_and_kidney_sensitivity|nsubj|Effect deficiency_on_rat_bone_and_kidney_sensitivity|xcomp|END_ENTITY	Effect of magnesium deficiency_on_rat_bone_and_kidney_sensitivity to parathyroid_hormone .
8074852	0	magnesium	101,110	parathyroid_hormone	11,30	magnesium	parathyroid hormone	MESH:D008274	101120013	Chemical	Gene	absorption|nmod|START_ENTITY rates|nmod|absorption END_ENTITY|nmod|rates	Effects of parathyroid_hormone and parathyroid_hormone-related_protein on the rates of absorption of magnesium , calcium , sodium , potassium and phosphate ions from the reticulo-rumen of sheep .
8586780	0	magnesium	129,138	parathyroid_hormone	78,97	magnesium	parathyroid hormone	MESH:D008274	24694(Tax:10116)	Chemical	Gene	deficiency|compound|START_ENTITY Changes|nmod|deficiency Changes|nmod|END_ENTITY	Changes in tissue calcium and phosphorus content and plasma concentrations of parathyroid_hormone and calcitonin after long-term magnesium deficiency in rats .
8712421	0	magnesium	33,42	parathyroid_hormone	66,85	magnesium	parathyroid hormone	MESH:D008274	5741	Chemical	Gene	depletion|nmod|START_ENTITY limit|nsubj|depletion limit|xcomp|END_ENTITY	Protamine and acute depletion of magnesium limit bone response to parathyroid_hormone .
2953122	0	magnesium	15,24	pyruvate_kinase	48,63	magnesium	pyruvate kinase	MESH:D008274	1253409(Tax:99287)	Chemical	Gene	START_ENTITY|nmod|reaction reaction|nmod|END_ENTITY	On the role of magnesium in the reaction of the pyruvate_kinase from Salmonella_typhimurium .
217454	0	magnesium	66,75	thiamine_pyrophosphokinase	25,51	magnesium	thiamine pyrophosphokinase	MESH:D008274	680668(Tax:10116)	Chemical	Gene	-RSB-|compound|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- Mechanisms of rat liver thiamine_pyrophosphokinase activation by magnesium ions -RSB- .
23960051	0	magnesium	14,23	transketolase	54,67	magnesium	transketolase	MESH:D008274	7086	Chemical	Gene	administration|compound|START_ENTITY administration|nmod|activity activity|compound|END_ENTITY	The effect of magnesium administration on erythrocyte transketolase activity in alcoholic patients treated with thiamine .
8054263	0	magnesium	11,20	transketolase	83,96	magnesium	transketolase	MESH:D008274	7086	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of magnesium , high_energy_phosphates , piracetam and thiamin on erythrocyte transketolase .
8747488	0	magnesium_chloride	94,112	Acetylcholinesterase	0,20	magnesium chloride	Acetylcholinesterase	MESH:D015636	43	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|dep|effect	Acetylcholinesterase of human intestinal tissue affected by Hirschsprung 's _ disease : effect of magnesium_chloride on isoforms .
7904896	0	magnesium_hydroxide	22,41	c-myc	45,50	magnesium hydroxide	c-myc	MESH:D008276	24577(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Inhibitory effects of magnesium_hydroxide on c-myc expression and cell proliferation induced by methylazoxymethanol_acetate in rat colon .
26869766	0	magnesium_isoglycyrrhizinate	63,91	CD25	120,124	magnesium isoglycyrrhizinate	CD25	MESH:C521270	16184(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Amelioration of concanavalin A-induced autoimmune_hepatitis by magnesium_isoglycyrrhizinate through inhibition of CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- CD69 -LRB- + -RRB- subset proliferation .
14515790	0	magnesium_lithospermate_B	15,40	c-Jun_N-terminal_kinase_3	48,73	magnesium lithospermate B	c-Jun N-terminal kinase 3	MESH:C061091	25272(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Inhibition of magnesium_lithospermate_B on the c-Jun_N-terminal_kinase_3 mRNA expression in cardiomyocytes encountered ischemia/reperfusion injury -RSB- .
17083835	0	magnesium_sulfate	11,28	caspase-3	107,116	magnesium sulfate	caspase-3	MESH:D008278	25402(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Effect of magnesium_sulfate on fetal rats of fetal_growth_retardation and its relation with expression of caspase-3 on the placenta of maternal rat -RSB- .
6830347	0	magnesium_sulfate	79,96	cholecystokinin	52,67	magnesium sulfate	cholecystokinin	MESH:D008278	885	Chemical	Gene	Correlation|nmod|START_ENTITY Correlation|nmod|END_ENTITY	Correlation between gallbladder size and release of cholecystokinin after oral magnesium_sulfate in man .
25655525	0	magnesium_sulfate	14,31	corticotropin-releasing_factor	49,79	magnesium sulfate	corticotropin-releasing factor	MESH:D008278	1392	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of magnesium_sulfate on the placental corticotropin-releasing_factor -LRB- CRF -RRB- and CRF_binding_protein mRNA expression in perfused human placental cotyledon .
1471664	0	magnesium_sulfate	10,27	endothelin-1	38,50	magnesium sulfate	endothelin-1	MESH:D008278	1906	Chemical	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Effect of magnesium_sulfate on plasma endothelin-1 levels in normal and preeclamptic pregnancies .
23725083	0	magnesium_sulfate	15,32	vascular_endothelial_growth_factor	46,80	magnesium sulfate	vascular endothelial growth factor	MESH:D008278	7422	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|compound|END_ENTITY	The effects of magnesium_sulfate on placental vascular_endothelial_growth_factor expression in preeclampsia .
17631287	0	magnesium_sulphate	11,29	endothelin_1	57,69	magnesium sulphate	endothelin 1	CHEBI:32599	1906	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of magnesium_sulphate on placental expression of endothelin_1 and its receptors in preeclampsia .
17321517	0	magnolol	10,18	TGF-beta1	22,31	magnolol	TGF-beta1	MESH:C005498	7040	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effect of magnolol on TGF-beta1 and fibronectin expression in human retinal pigment epithelial cells under diabetic conditions .
22683864	0	magnolol	14,22	Toll-like_receptor_4	30,50	magnolol	Toll-like receptor 4	MESH:C005498	21898(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of magnolol on the Toll-like_receptor_4 / nuclear factor kB signaling pathway in lipopolysaccharide-induced acute_lung_injury in mice .
22591254	0	magnolol	35,43	UGT1A7	71,77	magnolol	UGT1A7	MESH:C005498	54577	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Potent and selective inhibition of magnolol on catalytic activities of UGT1A7 and 1A9 .
23160676	0	magnolol	34,42	cyclooxygenase-2	81,97	magnolol	cyclooxygenase-2	MESH:C005498	19225(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|amod|END_ENTITY	Comparative inhibitory effects of magnolol , honokiol , eugenol and bis-eugenol on cyclooxygenase-2 expression and nuclear factor-kappa B activation in RAW264 .7 macrophage-like cells stimulated with fimbriae of Porphyromonas_gingivalis .
15769806	0	malate	62,68	ALMT1	82,87	malate	ALMT1	MESH:C030298	543388(Tax:4565)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Evidence for the plasma membrane localization of Al-activated malate transporter -LRB- ALMT1 -RRB- .
1447211	0	malate	78,84	MDH3	62,66	malate	MDH3	MESH:C030298	851481(Tax:4932)	Chemical	Gene	dehydrogenase|amod|START_ENTITY isozyme|nmod|dehydrogenase isozyme|compound|END_ENTITY	Isolation and characterization of the yeast gene encoding the MDH3 isozyme of malate dehydrogenase .
14570268	0	malate	30,36	MDH3	51,55	malate	MDH3	MESH:C030298	851481(Tax:4932)	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Overexpression of peroxisomal malate dehydrogenase MDH3 gene enhances cell death on H2O2 stress in the ald5 mutant of Saccharomyces_cerevisiae .
10750703	0	malate	8,14	phosphoenolpyruvate_carboxylase	37,68	malate	phosphoenolpyruvate carboxylase	MESH:C030298	5105	Chemical	Gene	synthesis|amod|START_ENTITY Role|nmod|synthesis mediated|nsubj|Role mediated|nmod|END_ENTITY	Role of malate synthesis mediated by phosphoenolpyruvate_carboxylase in guard cells in the regulation of stomatal movement .
16667297	0	malate	49,55	phosphoenolpyruvate_carboxylase	14,45	malate	phosphoenolpyruvate carboxylase	MESH:C030298	100101511(Tax:4577)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of phosphoenolpyruvate_carboxylase by malate .
24271973	0	malate	114,120	phosphoenolpyruvate_carboxylase	38,69	malate	phosphoenolpyruvate carboxylase	MESH:C030298	5105	Chemical	Gene	study|nmod|START_ENTITY study|nmod|regulation regulation|nmod|END_ENTITY	A study of the in-vitro regulation of phosphoenolpyruvate_carboxylase from the epidermis of Commelina_communis by malate and glucose-6-phosphate .
18281741	0	malathion	58,67	AChE	14,18	malathion	AChE	MESH:D008294	540446(Tax:9913)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of AChE by single and simultaneous exposure to malathion and its degradation products .
18608787	0	malathion	22,31	AChE	14,18	malathion	AChE	MESH:D008294	540446(Tax:9913)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of AChE by malathion and some structurally similar compounds .
15008520	0	malathion	121,130	acetylcholinesterase	24,44	malathion	acetylcholinesterase	MESH:D008294	11423(Tax:10090)	Chemical	Gene	treatment|nmod|START_ENTITY inhibition|nmod|treatment inhibition|nmod|END_ENTITY	Selective inhibition of acetylcholinesterase in the cerebellum and hippocampus of mice following an acute treatment with malathion .
16716398	0	malathion	24,33	acetylcholinesterase	49,69	malathion	acetylcholinesterase	MESH:D008294	11423(Tax:10090)	Chemical	Gene	exposure|nmod|START_ENTITY inhibits|nsubj|exposure inhibits|dobj|END_ENTITY	Lactational exposure to malathion inhibits brain acetylcholinesterase in mice .
16782587	0	malathion	13,22	acetylcholinesterase	26,46	malathion	acetylcholinesterase	MESH:D008294	83817(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Influence of malathion on acetylcholinesterase activity in rats submitted to a forced swimming test .
18588939	0	malathion	24,33	acetylcholinesterase	92,112	malathion	acetylcholinesterase	MESH:D008294	83817(Tax:10116)	Chemical	Gene	metabolic_disruption|amod|START_ENTITY attenuates|dobj|metabolic_disruption Caffeic_acid|dep|attenuates Caffeic_acid|nsubj|liver liver|appos|involvement involvement|nmod|activity activity|amod|END_ENTITY	Caffeic_acid attenuates malathion induced metabolic_disruption in rat liver , involvement of acetylcholinesterase activity .
20035484	0	malathion	11,20	acetylcholinesterase	36,56	malathion	acetylcholinesterase	MESH:D008294	43	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|amod|END_ENTITY	Effects of malathion and cadmium on acetylcholinesterase activity and metallothionein levels in the fish Seriola dumerilli .
23404830	0	malathion	79,88	acetylcholinesterase	42,62	malathion	acetylcholinesterase	MESH:D008294	6037551(Tax:7176)	Chemical	Gene	resistance|compound|START_ENTITY associated|nmod|resistance associated|nsubj|genotyping genotyping|nmod|END_ENTITY	First molecular genotyping of insensitive acetylcholinesterase associated with malathion resistance in Culex_quinquefasciatus Say populations in Malaysia .
26979315	0	malathion	29,38	acetylcholinesterase	55,75	malathion	acetylcholinesterase	MESH:D008294	43	Chemical	Gene	pesticide|compound|START_ENTITY pesticide|acl|using using|dobj|biosensor biosensor|amod|END_ENTITY	Electrochemical detection of malathion pesticide using acetylcholinesterase biosensor based on glassy_carbon_electrode modified with conducting polymer film .
20939762	0	malbrancheamide	94,109	calmodulin	115,125	malbrancheamide	calmodulin	MESH:C529354	808	Chemical	Gene	studies|nmod|START_ENTITY studies|nmod|END_ENTITY	Fluorescence , circular dichroism , NMR , and docking studies of the interaction of the alkaloid malbrancheamide with calmodulin .
17307360	0	malonamide	6,16	kappa_opioid_receptor	39,60	malonamide	kappa opioid receptor	MESH:C008314	4986	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	Novel malonamide derivatives as potent kappa_opioid_receptor agonists .
4465902	0	malonate	14,22	SDH	50,53	malonate	SDH	MESH:C030290	6390	Chemical	Gene	START_ENTITY|nmod|activity activity|appos|END_ENTITY	The effect of malonate on succinic_dehydrogenase -LRB- SDH -RRB- activity during the multiplication of influenza and herpes viruses in the embryonate hen egg .
4465902	0	malonate	14,22	succinic_dehydrogenase	26,48	malonate	succinic dehydrogenase	MESH:C030290	6390	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	The effect of malonate on succinic_dehydrogenase -LRB- SDH -RRB- activity during the multiplication of influenza and herpes viruses in the embryonate hen egg .
17460094	2	malondialdehyde	949,964	MDA	966,969	malondialdehyde	SP4	MESH:D008315	6671	Chemical	Gene	production|amod|START_ENTITY production|compound|END_ENTITY	Cryopreservation injuries were assessed in terms of postthaw sperm motility -LRB- assessed by computer-assisted sperm analysis -RRB- , viability -LRB- plasma membrane and acrosome integrity assessed simultaneously by flow cytometry -RRB- , membrane lipid peroxidation -LRB- malondialdehyde -LSB- MDA -RSB- production -RRB- , and the ability of thawed spermatozoa to fertilize in vitro-matured homologous oocytes .
23438161	4	malondialdehyde	488,503	MDA	505,508	malondialdehyde	SOD	MESH:D008315	6647	Chemical	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Fasting serum malondialdehyde -LRB- MDA -RRB- levels and anti-oxidant indices , including superoxide_dismutase -LRB- SOD -RRB- and catalase -LRB- CAT -RRB- activity , and glutathione -LRB- GSH -RRB- levels , were measured at baseline and 2 weeks after the first measurement .
6612739	0	malondialdehyde	14,29	aldehyde_dehydrogenase	43,65	malondialdehyde	aldehyde dehydrogenase	MESH:D008315	25375(Tax:10116)	Chemical	Gene	Metabolism|nmod|START_ENTITY END_ENTITY|nsubj|Metabolism	Metabolism of malondialdehyde by rat liver aldehyde_dehydrogenase .
13129735	0	malondialdehyde	100,115	superoxide_dismutase	24,44	malondialdehyde	superoxide dismutase	MESH:D008315	6647	Chemical	Gene	START_ENTITY|nsubj|Determination Determination|nmod|END_ENTITY	-LSB- Determination of serum superoxide_dismutase , glutathione peroxidase , total antioxidative capacity , malondialdehyde in patients with pneumonia -RSB- .
10710500	0	malonyl-CoA	24,35	CPT_I	15,20	malonyl-CoA	CPT I	MESH:D008316	1375	Chemical	Gene	Sensitivity|nmod|START_ENTITY Sensitivity|nmod|END_ENTITY	Sensitivity of CPT_I to malonyl-CoA in trained and untrained human skeletal muscle .
7575418	0	malonyl-CoA	35,46	carnitine_palmitoyltransferase-I	89,121	malonyl-CoA	carnitine palmitoyltransferase-I	MESH:D008316	25756(Tax:10116)	Chemical	Gene	sensitivity|amod|START_ENTITY sensitivity|nmod|END_ENTITY	Insulin regulates enzyme activity , malonyl-CoA sensitivity and mRNA abundance of hepatic carnitine_palmitoyltransferase-I .
3520129	0	maltitol	34,42	insulin	89,96	maltitol	insulin	MESH:C010745	3630	Chemical	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	Effects of oral administration of maltitol on plasma glucose , plasma sorbitol , and serum insulin levels in man .
17317091	0	maltol	62,68	cytochrome_P450_1a1	13,32	maltol	cytochrome P450 1a1	MESH:C008316	13076(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Induction Induction|nmod|END_ENTITY	Induction of cytochrome_P450_1a1 by the food flavoring agent , maltol .
9987646	0	maltose	84,91	acid_alpha_glucosidase	120,142	maltose	acid alpha glucosidase	MESH:D008320	367562(Tax:10116)	Chemical	Gene	activities|amod|START_ENTITY activities|compound|END_ENTITY	The degradation of glycogen in the lysosomes of newborn rat hepatocytes : glycogen - , maltose - and isomaltose-hydrolyzing acid_alpha_glucosidase activities in liver .
7012112	0	maltose	18,25	malB	39,43	maltose	malB	MESH:D008320	13906291	Chemical	Gene	transport|amod|START_ENTITY transport|nmod|END_ENTITY	Reconstitution of maltose transport in malB mutants of Escherichia_coli through calcium-induced disruptions of the outer membrane .
16258248	0	manassantin_B	33,46	NF-IL6	14,20	manassantin B	NF-IL6	MESH:C482885	1051	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activity activity|compound|END_ENTITY	Inhibition of NF-IL6 activity by manassantin_B , a dilignan isolated from Saururus chinensis , in phorbol_myristate_acetate-stimulated U937 promonocytic cells .
22379572	0	manassantin_B	10,23	interleukin-1b	98,112	manassantin B	interleukin-1b	MESH:C482885	16176(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|cells cells|amod|END_ENTITY	Effect of manassantin_B , a lignan isolated from Saururus chinensis , on lipopolysaccharide-induced interleukin-1b in RAW 264.7 cells .
8516783	0	mancozeb	10,18	glutathione_S-transferase	30,55	mancozeb	glutathione S-transferase	MESH:C013099	58962(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of mancozeb on hepatic glutathione_S-transferase in rat .
19218460	0	manganese	2,11	BB0219	25,31	manganese	BB0219	MESH:D008345	2662296(Tax:257310)	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	A manganese transporter , BB0219 -LRB- BmtA -RRB- , is required for virulence by the Lyme_disease spirochete , Borrelia_burgdorferi .
19084589	0	manganese	44,53	COX-2	13,18	manganese	COX-2	MESH:D008345	4513	Chemical	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	Induction of COX-2 in human airway cells by manganese : role of PI3K/PKB , p38 MAPK , PKCs , Src , and glutathione depletion .
17387379	0	manganese	38,47	DAT	14,17	manganese	DAT	MESH:D008345	24898(Tax:10116)	Chemical	Gene	accumulation|amod|START_ENTITY attenuates|dobj|accumulation attenuates|nsubj|Inhibition Inhibition|nmod|function function|compound|END_ENTITY	Inhibition of DAT function attenuates manganese accumulation in the globus pallidus .
23313730	0	manganese	14,23	DAT	71,74	manganese	DAT	MESH:D008345	6531	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of manganese on dopamine toxicity and dopamine_transporter -LRB- DAT -RRB- in control and DAT transfected HEK cells .
12112209	0	manganese	85,94	Dopamine_transporter	0,20	manganese	Dopamine transporter	MESH:D008345	6531	Chemical	Gene	exposure|amod|START_ENTITY history|nmod|exposure decreased|nmod|history decreased|nsubjpass|density density|compound|END_ENTITY	Dopamine_transporter density is decreased in parkinsonian patients with a history of manganese exposure : what does it mean ?
14648150	0	manganese	40,49	Dopamine_transporter	0,20	manganese	Dopamine transporter	MESH:D008345	6531	Chemical	Gene	intoxication|compound|START_ENTITY binding|nmod|intoxication END_ENTITY|xcomp|binding	Dopamine_transporter binding in chronic manganese intoxication .
26309447	0	manganese	35,44	GSTP1	19,24	manganese	GSTP1	MESH:D008345	2950	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|END_ENTITY	Synergic effect of GSTP1 and blood manganese concentrations in Autism_Spectrum_Disorder .
1482398	0	manganese	39,48	MnSOD	30,35	manganese	MnSOD	MESH:D008345	20656(Tax:10090)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of MnSOD by manganese in the liver of manganese-deficient mice and during rat development .
16118651	0	manganese	29,38	MnSOD	92,97	manganese	MnSOD	MESH:D008345	6648	Chemical	Gene	intake|amod|START_ENTITY Influence|nmod|intake Influence|nmod|END_ENTITY	Influence of tea drinking on manganese intake , manganese status and leucocyte expression of MnSOD and cytosolic_aminopeptidase_P .
20228245	0	manganese	14,23	NRAMP1	56,62	manganese	NRAMP1	MESH:D008345	844422(Tax:3702)	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|END_ENTITY	High-affinity manganese uptake by the metal transporter NRAMP1 is essential for Arabidopsis growth in low manganese conditions .
21262206	0	manganese	36,45	Prolactin	0,9	manganese	Prolactin	MESH:D008345	24683(Tax:10116)	Chemical	Gene	neurotoxicity|amod|START_ENTITY marker|nmod|neurotoxicity marker|nsubj|END_ENTITY	Prolactin is a peripheral marker of manganese neurotoxicity .
22341972	0	manganese	112,121	SLC30A10	100,108	manganese	SLC30A10	MESH:D008345	55532	Chemical	Gene	transporter|amod|START_ENTITY END_ENTITY|appos|transporter	Syndrome of hepatic_cirrhosis , dystonia , polycythemia , and hypermanganesemia caused by mutations in SLC30A10 , a manganese transporter in man .
25319704	0	manganese	37,46	SLC30A10	0,8	manganese	SLC30A10	MESH:D008345	289353(Tax:10116)	Chemical	Gene	transporter|amod|START_ENTITY surface-localized|dobj|transporter cell|acl|surface-localized cell|nsubj|END_ENTITY	SLC30A10 is a cell surface-localized manganese efflux transporter , and parkinsonism-causing mutations block its intracellular trafficking and efflux activity .
26430566	0	manganese	18,27	SLC30A10	0,8	manganese	SLC30A10	MESH:D008345	289353(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|dep|transporter	SLC30A10 : A novel manganese transporter .
22154916	0	manganese	25,34	acetylcholinesterase	38,58	manganese	acetylcholinesterase	MESH:D008345	83817(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	The inhibitory effect of manganese on acetylcholinesterase activity enhances oxidative stress and neuroinflammation in the rat brain .
25246936	0	manganese	20,29	acetylcholinesterase	37,57	manganese	acetylcholinesterase	MESH:D008345	83817(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|amod|END_ENTITY	The toxic effect of manganese on the acetylcholinesterase activity in rat brains .
21333719	0	manganese	20,29	alpha-synuclein	76,91	manganese	alpha-synuclein	MESH:D008345	6622	Chemical	Gene	exposure|nmod|START_ENTITY decreases|nsubj|exposure decreases|dobj|turnover turnover|nmod|transgenic_mice transgenic_mice|amod|END_ENTITY	Chronic exposure to manganese decreases striatal dopamine turnover in human alpha-synuclein transgenic_mice .
17084486	0	manganese	44,53	cyclooxygenase-2	13,29	manganese	cyclooxygenase-2	MESH:D008345	5743	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|expression expression|amod|END_ENTITY	Induction of cyclooxygenase-2 expression by manganese in cultured astrocytes .
22172096	0	manganese	25,34	divalent_metal_transporter_1	68,96	manganese	divalent metal transporter 1	MESH:D008345	4891	Chemical	Gene	transport|amod|START_ENTITY transport|nmod|END_ENTITY	Manganese source affects manganese transport and gene expression of divalent_metal_transporter_1 in the small intestine of broilers .
16325911	0	manganese	6,15	dopamine_transporter	38,58	manganese	dopamine transporter	MESH:D008345	6531	Chemical	Gene	administration|compound|START_ENTITY alters|nsubj|administration alters|dobj|levels levels|compound|END_ENTITY	Acute manganese administration alters dopamine_transporter levels in the non-human primate striatum .
18485605	0	manganese	10,19	dopamine_transporter	36,56	manganese	dopamine transporter	MESH:D008345	24898(Tax:10116)	Chemical	Gene	function|compound|START_ENTITY function|compound|END_ENTITY	Postnatal manganese exposure alters dopamine_transporter function in adult rats : Potential impact on nonassociative and associative processes .
2787543	0	manganese	16,25	glutathione-S-transferase	43,68	manganese	glutathione-S-transferase	MESH:D008345	373156	Chemical	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of manganese with human brain glutathione-S-transferase .
10403426	0	manganese	110,119	glyceraldehyde-3-phosphate_dehydrogenase	24,64	manganese	glyceraldehyde-3-phosphate dehydrogenase	MESH:D008345	2597	Chemical	Gene	expression|acl|START_ENTITY expression|nmod|END_ENTITY	Increased expression of glyceraldehyde-3-phosphate_dehydrogenase in cultured astrocytes following exposure to manganese .
17290048	0	manganese	10,19	luteinizing_hormone-releasing_hormone	23,60	manganese	luteinizing hormone-releasing hormone	MESH:D008345	25194(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|amod|END_ENTITY	Effect of manganese on luteinizing_hormone-releasing_hormone secretion in adult male rats .
18603625	0	manganese	16,25	luteinizing_hormone_releasing_hormone	42,79	manganese	luteinizing hormone releasing hormone	MESH:D008345	25194(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Acute effect of manganese on hypothalamic luteinizing_hormone_releasing_hormone secretion in adult male rats : involvement of specific neurotransmitter systems .
15727177	0	manganese	22,31	manganese-containing_superoxide_dismutase	55,96	manganese	manganese-containing superoxide dismutase	MESH:D008345	100101896(Tax:3847)	Chemical	Gene	sources|amod|START_ENTITY Bioavailabilities|nmod|sources based|nsubj|Bioavailabilities based|nmod|expression expression|amod|END_ENTITY	-LSB- Bioavailabilities of manganese sources based on heart manganese-containing_superoxide_dismutase gene expression for broilers -RSB- .
17435022	0	manganese	109,118	manganese-containing_superoxide_dismutase	19,60	manganese	manganese-containing superoxide dismutase	MESH:D008345	6648	Chemical	Gene	sources|amod|START_ENTITY expression|nmod|sources expression|nmod|END_ENTITY	Gene expression of manganese-containing_superoxide_dismutase as a biomarker of manganese bioavailability for manganese sources in broilers .
17435022	0	manganese	79,88	manganese-containing_superoxide_dismutase	19,60	manganese	manganese-containing superoxide dismutase	MESH:D008345	6648	Chemical	Gene	bioavailability|amod|START_ENTITY biomarker|nmod|bioavailability expression|nmod|biomarker expression|nmod|END_ENTITY	Gene expression of manganese-containing_superoxide_dismutase as a biomarker of manganese bioavailability for manganese sources in broilers .
6122537	0	manganese	23,32	monoamine_oxidase	60,77	manganese	monoamine oxidase	MESH:D008345	29253(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of chronic manganese feeding on the activity of monoamine_oxidase in various organs of the developing rat .
17210574	0	manganese	60,69	oxalate_oxidase	77,92	manganese	oxalate oxidase	MESH:D008345	548260(Tax:4513)	Chemical	Gene	ion|compound|START_ENTITY ion|nmod|END_ENTITY	Burst kinetics and redox transformations of the active site manganese ion in oxalate_oxidase : implications for the catalytic mechanism .
15451044	0	manganese	6,15	prolactin	48,57	manganese	prolactin	MESH:D008345	5617	Chemical	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	Blood manganese content at birth and cord serum prolactin levels .
25456232	0	manganese	153,162	prolactin	69,78	manganese	prolactin	MESH:D008345	5617	Chemical	Gene	exposed|xcomp|START_ENTITY catfish|acl|exposed protects|nmod|catfish protects|nmod|damage damage|nmod|expression expression|compound|END_ENTITY	Hypoxia acclimation protects against oxidative damage and changes in prolactin and somatolactin expression in silver catfish -LRB- Rhamdia quelen -RRB- exposed to manganese .
8834356	0	manganese	54,63	prolactin	6,15	manganese	prolactin	MESH:D008345	5617	Chemical	Gene	exposed|xcomp|START_ENTITY exposed|nsubj|END_ENTITY	Serum prolactin in subjects occupationally exposed to manganese .
8773758	0	manganese	7,16	pyruvate_carboxylase	34,54	manganese	pyruvate carboxylase	MESH:D008345	25104(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY END_ENTITY|nsubj|levels	Tissue manganese levels and liver pyruvate_carboxylase activity in magnesium-deficient rats .
24317669	1	manganese	164,173	superoxide_dismutase	105,125	manganese	superoxide dismutase	MESH:D008345	6647	Chemical	Gene	content|compound|START_ENTITY END_ENTITY|nmod|content	Cold and dark-induced changes in chloroplast superoxide_dismutase activity in relation to loosely-bound manganese content .
1816675	0	manganese	11,20	transketolase	24,37	manganese	transketolase	MESH:D008345	100350406(Tax:9986)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	-LSB- Effect of manganese on transketolase activity and total pentose content in rabbits -RSB- .
21310168	0	manganese	11,20	tyrosine_hydroxylase	24,44	manganese	tyrosine hydroxylase	MESH:D008345	7054	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|amod|END_ENTITY	Effects of manganese on tyrosine_hydroxylase -LRB- TH -RRB- activity and TH-phosphorylation in a dopaminergic neural cell line .
20136329	0	manganese_phthalocyanine	22,46	Spin	0,4	manganese phthalocyanine	Spin	null	10927	Chemical	Gene	effect|nmod|START_ENTITY effect|compound|END_ENTITY	Spin filter effect of manganese_phthalocyanine contacted with single-walled carbon nanotube electrodes .
11023599	0	manganese_superoxide	44,64	MnSOD	76,81	manganese superoxide	MnSOD	null	20656(Tax:10090)	Chemical	Gene	dismutase|amod|START_ENTITY dismutase|appos|END_ENTITY	Decreased_pulmonary_radiation resistance of manganese_superoxide dismutase -LRB- MnSOD -RRB- - deficient mice is corrected by human manganese_superoxide dismutase-Plasmid/Liposome -LRB- SOD2-PL -RRB- intratracheal gene therapy .
11241326	0	manganese_superoxide	18,38	MnSOD	50,55	manganese superoxide	MnSOD	null	20656(Tax:10090)	Chemical	Gene	dismutase|amod|START_ENTITY dismutase|appos|END_ENTITY	Overexpression of manganese_superoxide dismutase -LRB- MnSOD -RRB- in whole lung or alveolar_type_II cells of MnSOD transgenic_mice does not provide intrinsic lung irradiation protection .
11323405	0	manganese_superoxide	20,40	MnSOD	52,57	manganese superoxide	MnSOD	null	6648	Chemical	Gene	dismutase|amod|START_ENTITY dismutase|dep|END_ENTITY	Association between manganese_superoxide dismutase -LRB- MnSOD -RRB- gene polymorphism and breast_cancer risk .
12176043	0	manganese_superoxide	47,67	MnSOD	79,84	manganese superoxide	MnSOD	null	20656(Tax:10090)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Model mice for tissue-specific deletion of the manganese_superoxide dismutase -LRB- MnSOD -RRB- gene .
12829021	0	manganese_superoxide	36,56	MnSOD	68,73	manganese superoxide	MnSOD	null	6648	Chemical	Gene	dismutase|amod|START_ENTITY dismutase|appos|END_ENTITY	Overexpression of the transgene for manganese_superoxide dismutase -LRB- MnSOD -RRB- in 32D cl 3 cells prevents apoptosis induction by TNF-alpha , IL-3 withdrawal , and ionizing radiation .
15213518	0	manganese_superoxide	19,39	MnSOD	51,56	manganese superoxide	MnSOD	null	6648	Chemical	Gene	dismutase|amod|START_ENTITY dismutase|appos|END_ENTITY	Asbestos exposure , manganese_superoxide dismutase -LRB- MnSOD -RRB- genotype , and lung_cancer risk .
16458347	0	manganese_superoxide	21,41	MnSOD	53,58	manganese superoxide	MnSOD	null	6648	Chemical	Gene	dismutase|amod|START_ENTITY dismutase|appos|END_ENTITY	C47T polymorphism in manganese_superoxide dismutase -LRB- MnSOD -RRB- , antioxidant intake and survival .
16780268	0	manganese_superoxide	28,48	MnSOD	60,65	manganese superoxide	MnSOD	null	6648	Chemical	Gene	correlates|amod|START_ENTITY correlates|appos|END_ENTITY	-LSB- Functional polymorphism of manganese_superoxide dismutase -LRB- MnSOD -RRB- gene correlates with schizophrenia in Polish population -RSB- .
19262996	0	manganese_superoxide	20,40	MnSOD	52,57	manganese superoxide	MnSOD	null	6648	Chemical	Gene	dismutase|amod|START_ENTITY dismutase|appos|END_ENTITY	Association between manganese_superoxide dismutase -LRB- MnSOD -RRB- gene polymorphism and elderly obesity .
20863520	0	manganese_superoxide	49,69	MnSOD	81,86	manganese superoxide	MnSOD	null	6648	Chemical	Gene	dismutase|amod|START_ENTITY dismutase|appos|END_ENTITY	Macrophage_migration_inhibitory_factor -LRB- MIF -RRB- and manganese_superoxide dismutase -LRB- MnSOD -RRB- as early predictors for survival in patients with severe sepsis or septic_shock .
21705328	0	manganese_superoxide	94,114	MnSOD	126,131	manganese superoxide	MnSOD	null	6648	Chemical	Gene	dismutase|compound|START_ENTITY dismutase|appos|END_ENTITY	Dual function of protein_kinase_C -LRB- PKC -RRB- in 12-O-tetradecanoylphorbol-13-acetate -LRB- TPA -RRB- - induced manganese_superoxide dismutase -LRB- MnSOD -RRB- expression : activation of CREB and FOXO3a by PKC-alpha phosphorylation and by PKC-mediated inactivation of Akt , respectively .
22193621	0	manganese_superoxide	108,128	MnSOD	140,145	manganese superoxide	MnSOD	null	6648	Chemical	Gene	dismutase|amod|START_ENTITY dismutase|dep|END_ENTITY	Elevated risk of hypertension induced by arsenic exposure in Taiwanese rural residents : possible effects of manganese_superoxide dismutase -LRB- MnSOD -RRB- and 8-oxoguanine_DNA_glycosylase -LRB- OGG1 -RRB- genes .
22393988	0	manganese_superoxide	16,36	MnSOD	48,53	manganese superoxide	MnSOD	null	6648	Chemical	Gene	dismutase|amod|START_ENTITY dismutase|appos|END_ENTITY	Low activity of manganese_superoxide dismutase -LRB- MnSOD -RRB- in blood of lung_cancer patients with smoking history : relationship to oxidative stress .
22789716	0	manganese_superoxide	2,22	MnSOD	34,39	manganese superoxide	MnSOD	null	6648	Chemical	Gene	dismutase|amod|START_ENTITY dismutase|appos|END_ENTITY	A manganese_superoxide dismutase -LRB- MnSOD -RRB- from Ruditapes_philippinarum : comparative structural - and expressional-analysis with copper/zinc _ superoxide dismutase -LRB- Cu/ZnSOD -RRB- and biochemical analysis of its antioxidant activities .
23725507	0	manganese_superoxide	12,32	MnSOD	44,49	manganese superoxide	MnSOD	null	6648	Chemical	Gene	dismutase|amod|START_ENTITY dismutase|dep|END_ENTITY	Analysis of manganese_superoxide dismutase -LRB- MnSOD : Ala-9Val -RRB- and glutathione peroxidase -LRB- GSH-Px : Pro_197_Leu -RRB- gene polymorphisms in mood_disorders .
24055523	0	manganese_superoxide	105,125	MnSOD	137,142	manganese superoxide	MnSOD	null	6648	Chemical	Gene	dismutase|amod|START_ENTITY dismutase|appos|END_ENTITY	Acid-degradable core-shell nanoparticles for reversed tamoxifen-resistance in breast_cancer by silencing manganese_superoxide dismutase -LRB- MnSOD -RRB- .
26505452	0	manganese_superoxide	26,46	MnSOD	58,63	manganese superoxide	MnSOD	null	6648	Chemical	Gene	dismutase|amod|START_ENTITY dismutase|dep|END_ENTITY	Polymorphic variations in manganese_superoxide dismutase -LRB- MnSOD -RRB- and endothelial_nitric_oxide_synthase -LRB- eNOS -RRB- genes contribute to the development of type_2_diabetes_mellitus in the Chinese Han population .
9576743	0	manganese_superoxide	21,41	MnSOD	53,58	manganese superoxide	MnSOD	null	6648	Chemical	Gene	dismutase|amod|START_ENTITY dismutase|appos|END_ENTITY	Stable expression of manganese_superoxide dismutase -LRB- MnSOD -RRB- in insulinoma cells prevents IL-1beta - induced cytotoxicity and reduces nitric_oxide production .
7561947	1	manganese_superoxide	136,156	Mn_SOD	168,174	manganese superoxide	Mn SOD	null	6648	Chemical	Gene	dismutase|amod|START_ENTITY dismutase|appos|END_ENTITY	We examined the mechanism of increase of manganese_superoxide dismutase -LRB- Mn_SOD -RRB- in the cerebrospinal fluid -LRB- CSF -RRB- in bacterial_meningitis -LRB- BM -RRB- .
15908783	0	manganese_superoxide	24,44	SOD-2	56,61	manganese superoxide	SOD-2	null	6648	Chemical	Gene	dismutase|amod|START_ENTITY dismutase|dep|END_ENTITY	Epigenetic silencing of manganese_superoxide dismutase -LRB- SOD-2 -RRB- in KAS 6/1 human multiple_myeloma cells increases cell proliferation .
18439041	0	manganese_superoxide	15,35	SOD2	47,51	manganese superoxide	SOD2	null	6648	Chemical	Gene	dismutase|amod|START_ENTITY dismutase|appos|END_ENTITY	Maintenance of manganese_superoxide dismutase -LRB- SOD2 -RRB- - mediated delayed radioprotection induced by repeated administration of the free thiol form of amifostine .
20618948	0	manganese_superoxide	16,36	SOD2	48,52	manganese superoxide	SOD2	null	6648	Chemical	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Deregulation of manganese_superoxide dismutase -LRB- SOD2 -RRB- expression and lymph node metastasis in tongue_squamous_cell_carcinoma .
20596034	0	manganese_superoxide	18,38	angiotensin_II	52,66	manganese superoxide	angiotensin II	null	24179(Tax:10116)	Chemical	Gene	dismutase|amod|START_ENTITY dismutase|nmod|END_ENTITY	Downregulation of manganese_superoxide dismutase by angiotensin_II in cardiac fibroblasts of rats : Association with oxidative stress in myocardium .
8816815	0	manganese_superoxide	118,138	cyclooxygenase-2	100,116	manganese superoxide	cyclooxygenase-2	null	5743	Chemical	Gene	dismutase|amod|START_ENTITY dismutase|amod|END_ENTITY	Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli : cyclooxygenase-2 , manganese_superoxide dismutase , and endothelial cell nitric_oxide synthase are selectively up-regulated by steady laminar_shear_stress .
22465218	0	mangiferin	49,59	MMP-9	24,29	mangiferin	MMP-9	MESH:C013592	4318	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Selective inhibition of MMP-9 gene expression by mangiferin in PMA-stimulated human astroglioma cells : involvement of PI3K/Akt and MAPK signaling pathways .
24641381	0	mangiferin	68,78	MRP-1	39,44	mangiferin	MRP-1	MESH:C013592	4363	Chemical	Gene	expression|nmod|START_ENTITY expression|nsubj|END_ENTITY	In vitro modulation of P-glycoprotein , MRP-1 and BCRP expression by mangiferin in doxorubicin-treated MCF-7 cells .
23266284	0	mangiferin	29,39	heme_oxygenase-1	99,115	mangiferin	heme oxygenase-1	MESH:C013592	15368(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Anti-inflammatory effects of mangiferin on sepsis-induced lung_injury in mice via up-regulation of heme_oxygenase-1 .
22146720	0	mangiferin	95,105	matrix_metalloproteinase-1	14,40	mangiferin	matrix metalloproteinase-1	MESH:C013592	4312	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Inhibition of matrix_metalloproteinase-1 induced by oxidative stress in human keratinocytes by mangiferin isolated from Anemarrhena asphodeloides .
23113965	0	manidipine	11,21	insulin	90,97	manidipine	insulin	MESH:C054218	3630	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|resistance resistance|compound|END_ENTITY	Effects of manidipine plus rosuvastatin versus olmesartan plus rosuvastatin on markers of insulin resistance in patients with impaired fasting glucose , hypertension , and mixed dyslipidemia .
15085064	0	manidipine	10,20	p22phox	96,103	manidipine	p22phox	MESH:C054218	1535	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|END_ENTITY	Effect of manidipine on gene expression and protein level of oxidative stress-related proteins : p22phox and HO-1 : relevance for antihypertensive and anti-remodeling effects .
15898100	0	mannitol	13,21	Src	30,33	mannitol	Src	MESH:D008353	6714	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Hyperosmotic mannitol induces Src kinase-dependent phosphorylation of beta-catenin in cerebral endothelial cells .
15898100	0	mannitol	13,21	beta-catenin	70,82	mannitol	beta-catenin	MESH:D008353	1499	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Hyperosmotic mannitol induces Src kinase-dependent phosphorylation of beta-catenin in cerebral endothelial cells .
11841552	0	mannose	31,38	CD206	48,53	mannose	CD206	MESH:D008358	4360	Chemical	Gene	receptor|amod|START_ENTITY Expression|nmod|receptor END_ENTITY|nsubj|Expression	Expression and function of the mannose receptor CD206 on epidermal dendritic cells in inflammatory skin_diseases .
20477018	0	mannose	6,13	CD206	24,29	mannose	CD206	MESH:D008358	17533(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Human mannose receptor -LRB- CD206 -RRB- in immune response : novel insights into vaccination strategies using a humanized mouse model .
22069759	0	mannose	12,19	CD206	30,35	mannose	CD206	MESH:D008358	17533(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY Role|nmod|receptor Role|appos|END_ENTITY	Role of the mannose receptor -LRB- CD206 -RRB- in innate immunity to ricin toxin .
23241402	0	mannose	32,39	CD68	24,28	mannose	CD68	MESH:D008358	968	Chemical	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Role of proinflammatory CD68 -LRB- + -RRB- mannose receptor -LRB- - -RRB- macrophages in peroxiredoxin-1 expression and in abdominal_aortic_aneurysms in humans .
10383441	0	mannose	44,51	DNase_I	77,84	mannose	DNase I	MESH:D008358	13419(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Identification of amino_acids that modulate mannose phosphorylation of mouse DNase_I , a secretory glycoprotein .
12714575	0	mannose	12,19	IL-10	49,54	mannose	IL-10	MESH:D008358	16153(Tax:10090)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Analysis of mannose receptor regulation by IL-4 , IL-10 , and proteolytic processing using novel monoclonal antibodies .
20502521	0	mannose	37,44	IL-10	94,99	mannose	IL-10	MESH:D008358	16153(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY expression|nmod|receptor depends|nsubj|expression depends|nmod|responsiveness responsiveness|compound|END_ENTITY	IL-4Ralpha-independent expression of mannose receptor and Ym1 by macrophages depends on their IL-10 responsiveness .
9844054	0	mannose	137,144	IL-10	0,5	mannose	IL-10	MESH:D008358	3586	Chemical	Gene	receptor|amod|START_ENTITY uptake|nmod|receptor T|nmod|uptake T|nsubj|down-regulates down-regulates|compound|END_ENTITY	IL-10 down-regulates T cell activation by antigen-presenting liver sinusoidal endothelial cells through decreased antigen uptake via the mannose receptor and lowered surface expression of accessory molecules .
21613225	0	mannose	10,17	LIF	65,68	mannose	LIF	MESH:D008358	3976	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|appos|END_ENTITY	Extensive mannose phosphorylation on leukemia_inhibitory_factor -LRB- LIF -RRB- controls its extracellular levels by multiple mechanisms .
21887537	0	mannose	94,101	LY75	119,123	mannose	LY75	MESH:D008358	17076(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Interleukin-6 receptor enhances early colonization of the murine omentum by upregulation of a mannose family receptor , LY75 , in ovarian_tumor cells .
9038318	0	mannose	15,22	MIP-1beta	204,213	mannose	MIP-1beta	MESH:D008358	20303(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY Involvement|nmod|receptor Involvement|appos|END_ENTITY	Involvement of mannose receptor in cytokine interleukin-1beta -LRB- IL-1beta -RRB- , IL-6 , and granulocyte-macrophage_colony-stimulating_factor responses , but not in chemokine macrophage_inflammatory_protein_1beta -LRB- MIP-1beta -RRB- , MIP-2 , and KC responses , caused by attachment of Candida_albicans to macrophages .
9038318	0	mannose	15,22	MIP-2	216,221	mannose	MIP-2	MESH:D008358	20310(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY Involvement|nmod|receptor Involvement|appos|END_ENTITY	Involvement of mannose receptor in cytokine interleukin-1beta -LRB- IL-1beta -RRB- , IL-6 , and granulocyte-macrophage_colony-stimulating_factor responses , but not in chemokine macrophage_inflammatory_protein_1beta -LRB- MIP-1beta -RRB- , MIP-2 , and KC responses , caused by attachment of Candida_albicans to macrophages .
24114918	0	mannose	41,48	MR/CD206	59,67	mannose	MR/CD206	MESH:D008358	4360	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	A soluble form of the macrophage-related mannose receptor -LRB- MR/CD206 -RRB- is present in human serum and elevated in critical_illness .
19902202	0	mannose	24,31	MRC1	47,51	mannose	MRC1	MESH:D008358	4360	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic variants in the mannose receptor gene -LRB- MRC1 -RRB- are associated with asthma in two independent populations .
21029423	0	mannose	20,27	MRC1	43,47	mannose	MRC1	MESH:D008358	4360	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic variants in mannose receptor gene -LRB- MRC1 -RRB- confer susceptibility to increased risk of sarcoidosis .
14570881	0	mannose	18,25	Tamm-Horsfall_glycoprotein	36,62	mannose	Tamm-Horsfall glycoprotein	MESH:D008358	7369	Chemical	Gene	chains|compound|START_ENTITY chains|nmod|END_ENTITY	Variation of high mannose chains of Tamm-Horsfall_glycoprotein confers differential binding to type 1-fimbriated Escherichia_coli .
1932126	0	mannose	30,37	cathepsin_D	11,22	mannose	cathepsin D	MESH:D008358	171293(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY END_ENTITY|nmod|receptor	Binding of cathepsin_D to the mannose receptor on rat peritoneal macrophages .
9694859	0	mannose	49,56	cathepsin_D	76,87	mannose	cathepsin D	MESH:D008358	1509	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Lysine-based structure responsible for selective mannose phosphorylation of cathepsin_D and cathepsin_L defines a common structural motif for lysosomal enzyme targeting .
22132194	0	mannose	19,26	gp120	4,9	mannose	gp120	MESH:D008358	3700	Chemical	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	HIV gp120 binds to mannose receptor on vaginal epithelial cells and induces production of matrix metalloproteinases .
2158304	15	mannose	1985,1992	insulin	2046,2053	mannose	insulin	MESH:D008358	3630	Chemical	Gene	blocked|nmod|START_ENTITY blocked|advcl|unaffected unaffected|nsubj|effects effects|compound|END_ENTITY	We also found that the effect of insulin on lipogenesis was blocked by mannose , glucosamine and inositol_monophosphate , whereas the insulin effects on 3-O-methylglucose , cyclic_AMP and lipolysis were unaffected .
2654926	0	mannose	11,18	insulin	66,73	mannose	insulin	MESH:D008358	3630	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|synthesis synthesis|nmod|END_ENTITY	Effects of mannose and fructose on the synthesis and secretion of insulin .
5366873	0	mannose	12,19	insulin	23,30	mannose	insulin	MESH:D008358	3630	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	-LSB- Effects of mannose on insulin secretion -RSB- .
21613225	0	mannose	10,17	leukemia_inhibitory_factor	37,63	mannose	leukemia inhibitory factor	MESH:D008358	3976	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Extensive mannose phosphorylation on leukemia_inhibitory_factor -LRB- LIF -RRB- controls its extracellular levels by multiple mechanisms .
24424890	0	mannose	71,78	sMR	89,92	mannose	sMR	MESH:D008358	147719	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Macrophage-related serum biomarkers soluble CD163 -LRB- sCD163 -RRB- and soluble mannose receptor -LRB- sMR -RRB- to differentiate mild liver_fibrosis from cirrhosis in patients with chronic hepatitis_C : a pilot study .
9722572	5	mannose	898,905	sMR	856,859	mannose	sMR	MESH:D008358	54650(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY cleavage|nmod|receptor produced|nmod|cleavage produced|nsubjpass|END_ENTITY	Protease inhibitor studies suggested that sMR was produced by cleavage of an intact mannose receptor by a matrix metalloprotease or ADAM metalloprotease .
9492274	0	mannose	98,105	tissue-type_plasminogen_activator	51,84	mannose	tissue-type plasminogen activator	MESH:D008358	5327	Chemical	Gene	binding|nmod|START_ENTITY binding|nmod|END_ENTITY	Role of carbohydrate and protein in the binding of tissue-type_plasminogen_activator to the human mannose receptor .
2158429	0	mannose-6-phosphate	30,49	Insulin-like_growth_factor-II	0,29	mannose-6-phosphate	Insulin-like growth factor-II	MESH:C027693	24483(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY increased|nsubjpass|receptors END_ENTITY|parataxis|increased	Insulin-like_growth_factor-II / mannose-6-phosphate receptors are increased in hepatocytes from regenerating rat liver .
2932104	0	mannose-6-phosphate	103,122	N-acetyl-beta-D-glucosaminidase	68,99	mannose-6-phosphate	N-acetyl-beta-D-glucosaminidase	MESH:C027693	154968(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY END_ENTITY|nmod|receptors	The effect of the lysosomotropic drug chloroquine on the binding of N-acetyl-beta-D-glucosaminidase to mannose-6-phosphate recognizing receptors of rat liver .
2171910	0	mannose-6-phosphate	54,73	insulin-like_growth_factor-II	24,53	mannose-6-phosphate	insulin-like growth factor-II	MESH:C027693	24483(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Increased expression of insulin-like_growth_factor-II / mannose-6-phosphate receptor in regenerating rat liver .
15044437	0	mannose_6-phosphate	59,78	CD-MPR	89,95	mannose 6-phosphate	CD-MPR	MESH:C027693	4074	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	The acidic cluster of the CK2 site of the cation-dependent mannose_6-phosphate receptor -LRB- CD-MPR -RRB- but not its phosphorylation is required for GGA1 and AP-1 binding .
17475626	0	mannose_6-phosphate	74,93	IGF-II	106,112	mannose 6-phosphate	IGF-II	MESH:C027693	3481	Chemical	Gene	receptor|amod|START_ENTITY receptor|nmod|END_ENTITY	A novel binding site for the human insulin-like_growth_factor-II _ -LRB- IGF-II -RRB- / mannose_6-phosphate receptor on IGF-II .
1324932	0	mannose_6-phosphate	82,101	IGF_II	102,108	mannose 6-phosphate	IGF II	MESH:C027693	3481	Chemical	Gene	stimulated|xcomp|START_ENTITY Role|dep|stimulated END_ENTITY|nsubj|Role	Role of protein phosphatases in insulin-like growth factor II -LRB- IGF_II -RRB- - stimulated mannose_6-phosphate / IGF_II receptor redistribution .
1324932	0	mannose_6-phosphate	82,101	IGF_II	63,69	mannose 6-phosphate	IGF II	MESH:C027693	3481	Chemical	Gene	stimulated|xcomp|START_ENTITY Role|dep|stimulated Role|nmod|phosphatases phosphatases|nmod|II II|appos|END_ENTITY	Role of protein phosphatases in insulin-like growth factor II -LRB- IGF_II -RRB- - stimulated mannose_6-phosphate / IGF_II receptor redistribution .
2542023	0	mannose_6-phosphate	18,37	IGF_II	38,44	mannose 6-phosphate	IGF II	MESH:C027693	3481	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Regulation of the mannose_6-phosphate / IGF_II receptor expression at the cell surface by mannose_6-phosphate , insulin like growth factors and epidermal_growth_factor .
2542023	0	mannose_6-phosphate	88,107	IGF_II	38,44	mannose 6-phosphate	IGF II	MESH:C027693	3481	Chemical	Gene	surface|nmod|START_ENTITY surface|nsubj|Regulation Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of the mannose_6-phosphate / IGF_II receptor expression at the cell surface by mannose_6-phosphate , insulin like growth factors and epidermal_growth_factor .
20201808	0	mannose_6-phosphate	13,32	MPR300	44,50	mannose 6-phosphate	MPR300	MESH:C027693	3482	Chemical	Gene	receptors|amod|START_ENTITY receptors|dep|END_ENTITY	Evolution of mannose_6-phosphate receptors -LRB- MPR300 and 46 -RRB- : lysosomal enzyme sorting proteins .
11281260	0	mannose_6-phosphate	54,73	MPR_300	115,122	mannose 6-phosphate	MPR 300	MESH:C027693	3482	Chemical	Gene	receptors|amod|START_ENTITY structure|nmod|receptors structure|dep|sequence sequence|nmod|END_ENTITY	Conserved cassette structure of vertebrate Mr 300 kDa mannose_6-phosphate receptors : partial cDNA sequence of fish MPR_300 .
1647783	0	mannose_6-phosphate	38,57	MPR_46	68,74	mannose 6-phosphate	MPR 46	MESH:C027693	17113(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Molecular cloning of the mouse 46-kDa mannose_6-phosphate receptor -LRB- MPR_46 -RRB- .
2972705	1	mannose_6-phosphate	234,253	hCI-MPR	264,271	mannose 6-phosphate	hCI-MPR	MESH:C027693	3482	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	We recently reported the cDNA cloning , sequence , and expression of the human cation-independent mannose_6-phosphate receptor -LRB- hCI-MPR -RRB- -LRB- Oshima , A. , Nolan , C. M. , Kyle , J. W. , Grubb , J. H. , and Sly , W. S. -LRB- 1988 -RRB- J. Biol .
10884392	0	mannose_6-phosphate	90,109	insulin-like_growth_factor_II	110,139	mannose 6-phosphate	insulin-like growth factor II	MESH:C027693	16002(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Endocytosis of insulin-like_growth_factor_II by a mini-receptor based on repeat 11 of the mannose_6-phosphate / insulin-like_growth_factor_II receptor .
10884392	0	mannose_6-phosphate	90,109	insulin-like_growth_factor_II	15,44	mannose 6-phosphate	insulin-like growth factor II	MESH:C027693	16002(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY repeat|nmod|receptor based|nmod|repeat based|nsubj|Endocytosis Endocytosis|nmod|END_ENTITY	Endocytosis of insulin-like_growth_factor_II by a mini-receptor based on repeat 11 of the mannose_6-phosphate / insulin-like_growth_factor_II receptor .
2170379	0	mannose_6-phosphate	86,105	insulin-like_growth_factor_II	143,172	mannose 6-phosphate	insulin-like growth factor II	MESH:C027693	3481	Chemical	Gene	receptor|amod|START_ENTITY linkage|nmod|receptor linkage|nmod|END_ENTITY	Distinctive regulation of the functional linkage between the human cation-independent mannose_6-phosphate receptor and GTP-binding proteins by insulin-like_growth_factor_II and mannose_6-phosphate .
2540172	0	mannose_6-phosphate	37,56	insulin-like_growth_factor_II	107,136	mannose 6-phosphate	insulin-like growth factor II	MESH:C027693	395097(Tax:9031)	Chemical	Gene	receptor|amod|START_ENTITY liver|dep|receptor lacks|nsubj|liver lacks|dobj|site site|nmod|END_ENTITY	The chicken liver cation-independent mannose_6-phosphate receptor lacks the high affinity binding site for insulin-like_growth_factor_II .
2963812	0	mannose_6-phosphate	23,42	insulin-like_growth_factor_II	58,87	mannose 6-phosphate	insulin-like growth factor II	MESH:C027693	3481	Chemical	Gene	receptor|amod|START_ENTITY binds|nsubj|receptor binds|dobj|END_ENTITY	The cation-independent mannose_6-phosphate receptor binds insulin-like_growth_factor_II .
7797478	0	mannose_6-phosphate	108,127	insulin-like_growth_factor_II	128,157	mannose 6-phosphate	insulin-like growth factor II	MESH:C027693	3481	Chemical	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Localization of the insulin-like_growth_factor_II binding site to amino_acids 1508-1566 in repeat 11 of the mannose_6-phosphate / insulin-like_growth_factor_II receptor .
7797478	0	mannose_6-phosphate	108,127	insulin-like_growth_factor_II	20,49	mannose 6-phosphate	insulin-like growth factor II	MESH:C027693	3481	Chemical	Gene	receptor|amod|START_ENTITY Localization|nmod|receptor Localization|nmod|site site|compound|END_ENTITY	Localization of the insulin-like_growth_factor_II binding site to amino_acids 1508-1566 in repeat 11 of the mannose_6-phosphate / insulin-like_growth_factor_II receptor .
8010960	0	mannose_6-phosphate	132,151	insulin-like_growth_factor_II	102,131	mannose 6-phosphate	insulin-like growth factor II	MESH:C027693	3481	Chemical	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Stimulation of glucose uptake by insulin-like_growth_factor_II in human muscle is not mediated by the insulin-like_growth_factor_II / mannose_6-phosphate receptor .
8010960	0	mannose_6-phosphate	132,151	insulin-like_growth_factor_II	33,62	mannose 6-phosphate	insulin-like growth factor II	MESH:C027693	3481	Chemical	Gene	receptor|amod|START_ENTITY mediated|nmod|receptor mediated|nsubjpass|Stimulation Stimulation|nmod|uptake uptake|nmod|END_ENTITY	Stimulation of glucose uptake by insulin-like_growth_factor_II in human muscle is not mediated by the insulin-like_growth_factor_II / mannose_6-phosphate receptor .
8106425	0	mannose_6-phosphate	11,30	insulin-like_growth_factor_II	31,60	mannose 6-phosphate	insulin-like growth factor II	MESH:C027693	3481	Chemical	Gene	receptor|dep|START_ENTITY receptor|amod|END_ENTITY	The bovine mannose_6-phosphate / insulin-like_growth_factor_II receptor .
2155213	0	mannose_6-phosphate	90,109	lysosomal_cysteine_protease	36,63	mannose 6-phosphate	lysosomal cysteine protease	MESH:C027693	56835(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY END_ENTITY|nmod|receptor	Basis for low affinity binding of a lysosomal_cysteine_protease to the cation-independent mannose_6-phosphate receptor .
3192517	0	mannose_phosphate	12,29	epidermal_growth_factor_receptor	37,69	mannose phosphate	epidermal growth factor receptor	CHEBI:21060	1956	Chemical	Gene	Presence|nmod|START_ENTITY Presence|nmod|END_ENTITY	Presence of mannose_phosphate on the epidermal_growth_factor_receptor in A-431 cells .
12588002	0	mannosides	23,33	Langerin	49,57	mannosides	Langerin	MESH:D008362	50489	Chemical	Gene	Analysis|nmod|START_ENTITY Analysis|nmod|END_ENTITY	Analysis of binding of mannosides in relation to Langerin -LRB- CD207 -RRB- in Langerhans cells of normal and transformed epithelia .
19101978	0	mannostatin_A	67,80	Golgi_alpha-mannosidase_II	37,63	mannostatin A	Golgi alpha-mannosidase II	MESH:C060107	41126(Tax:7227)	Chemical	Gene	basis|nmod|START_ENTITY basis|nmod|END_ENTITY	The molecular basis of inhibition of Golgi_alpha-mannosidase_II by mannostatin_A .
2840081	0	manoalide	54,63	5-lipoxygenase	27,41	manoalide	5-lipoxygenase	MESH:C045673	240	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|activity activity|amod|END_ENTITY	Preferential inhibition of 5-lipoxygenase activity by manoalide .
8737743	0	manoalide	10,19	5-lipoxygenase	29,43	manoalide	5-lipoxygenase	MESH:C045673	240	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	Effect of manoalide on human 5-lipoxygenase activity .
3111475	0	manoalide	46,55	phospholipase_A2	26,42	manoalide	phospholipase A2	MESH:C045673	406141(Tax:7460)	Chemical	Gene	venom|nmod|START_ENTITY venom|dobj|END_ENTITY	Inactivation of bee venom phospholipase_A2 by manoalide .
3178877	0	manoalide	36,45	phospholipase_A2	16,32	manoalide	phospholipase A2	MESH:C045673	406141(Tax:7460)	Chemical	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of phospholipase_A2 by manoalide .
3178877	1	manoalide	67,76	phospholipase_A2	103,119	manoalide	phospholipase A2	MESH:C045673	406141(Tax:7460)	Chemical	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Localization of the manoalide binding site on bee venom phospholipase_A2 .
3801502	0	manoalide	38,47	phospholipase_A2	18,34	manoalide	phospholipase A2	MESH:C045673	151056	Chemical	Gene	analogues|amod|START_ENTITY inhibition|nmod|analogues inhibition|nmod|END_ENTITY	The inhibition of phospholipase_A2 by manoalide and manoalide analogues .
3997864	0	manoalide	43,52	phospholipase_A2	12,28	manoalide	phospholipase A2	MESH:C045673	151056	Chemical	Gene	venom|nmod|START_ENTITY venom|dobj|inhibition inhibition|amod|END_ENTITY	Cobra venom phospholipase_A2 inhibition by manoalide .
8515424	0	manoalide	70,79	phospholipase_A2	48,64	manoalide	phospholipase A2	MESH:C045673	406141(Tax:7460)	Chemical	Gene	model|nmod|START_ENTITY model|nmod|interaction interaction|nmod|END_ENTITY	Molecular model of the interaction of bee venom phospholipase_A2 with manoalide .
8702436	0	manoalide	47,56	phospholipase_A2	19,35	manoalide	phospholipase A2	MESH:C045673	151056	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	The effects of the phospholipase_A2 inhibitor , manoalide , on cartilage degradation , stromelysin expression , and synovial fluid cell count induced by intraarticular injection of human recombinant interleukin-1_alpha in the rabbit .
23051936	0	mapatumumab	60,71	Bcl-xL	12,18	mapatumumab	Bcl-xL	null	598	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of Bcl-xL in synergistic induction of apoptosis by mapatumumab and oxaliplatin in combination with hyperthermia on human colon_cancer .
21429239	0	maribavir	15,24	UL97	108,112	maribavir	UL97	MESH:C400401	3077517(Tax:10359)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|protein protein|compound|END_ENTITY	The effects of maribavir on the autophosphorylation of ganciclovir resistant mutants of the cytomegalovirus UL97 protein .
26725706	0	masitinib	45,54	KIT	124,127	masitinib	KIT	MESH:C526575	3815	Chemical	Gene	START_ENTITY|nmod|mutation mutation|compound|END_ENTITY	Rapid and clinically significant response to masitinib in the treatment of mucosal primary esophageal_melanoma with somatic KIT exon 11 mutation involving brain metastases : A case report .
19846303	0	maslinic_acid	69,82	protein_tyrosine_phosphatase_1B	118,149	maslinic acid	protein tyrosine phosphatase 1B	MESH:C412811	5770	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Synthesis and biological evaluation of heterocyclic ring-substituted maslinic_acid derivatives as novel inhibitors of protein_tyrosine_phosphatase_1B .
19935713	0	matairesinol	42,54	Akt	14,17	matairesinol	Akt	MESH:C068935	207	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Inhibition of Akt signaling by the lignan matairesinol sensitizes prostate_cancer cells to TRAIL-induced apoptosis .
18647534	0	matrine	12,19	APRIL	71,76	matrine	APRIL	MESH:C034244	8741	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of matrine , 5-fluorouracil and cisplatin on the expression of APRIL in hepatocellular_carcinoma HepG2 cells -RSB- .
17518040	0	matrine	12,19	HERG	51,55	matrine	HERG	MESH:C034244	3757	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Effects of matrine , oxymatrine and resveratrol on HERG channel expression -RSB- .
26040411	0	matrine	18,25	HSP72	103,108	matrine	HSP72	MESH:C034244	193740(Tax:10090)	Chemical	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of matrine as a promising novel drug for hepatic_steatosis and glucose_intolerance with HSP72 as an upstream target .
19166015	0	matrine	11,18	Stat3	69,74	matrine	Stat3	MESH:C034244	6774	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of matrine and oxymatrine on proliferation and expression of Stat3 and Stat5 in SMMC-7721 cell line -RSB- .
24857216	0	matrine	40,47	ULBP2	31,36	matrine	ULBP2	MESH:C034244	80328	Chemical	Gene	ligand|nmod|START_ENTITY ligand|dobj|END_ENTITY	-LSB- Up-regulation of NKG2D ligand ULBP2 by matrine in K562 cells and the underlying molecular mechanisms -RSB- .
26692928	0	matrine	139,146	ULBP2	31,36	matrine	ULBP2	MESH:C034244	80328	Chemical	Gene	immunotherapy|nmod|START_ENTITY underlying|dobj|immunotherapy mechanism|acl|underlying END_ENTITY|dep|mechanism	Matrine increases NKG2D ligand ULBP2 in K562 cells via inhibiting JAK/STAT3 pathway : a potential mechanism underlying the immunotherapy of matrine in leukemia .
15842147	0	matrine	31,38	cyclooxygenase-2	42,58	matrine	cyclooxygenase-2	MESH:C034244	5743	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Study on inhibitory effect of matrine on cyclooxygenase-2 expression in colon_cancer HT-29 cell line -RSB- .
26309553	0	matrine	4,11	miR122a	93,100	matrine	miR122a	MESH:C034244	406906	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	TCM matrine inducescell arrest and apoptosis with recovery expression of the hepato-specific miR122a in human hepatocellular_carcinomaHep G2cell line .
20840390	0	mavacoxib	24,33	COX-2	49,54	mavacoxib	COX-2	MESH:C555097	804479(Tax:9615)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	The pharmacokinetics of mavacoxib , a long-acting COX-2 inhibitor , in young adult laboratory dogs .
16650067	0	maximakinin	21,32	kallikrein	101,111	maximakinin	kallikrein	null	9622	Chemical	Gene	Biotransformation|nmod|START_ENTITY Biotransformation|nmod|END_ENTITY	Biotransformation of maximakinin , a bradykinin-related nonadecapeptide from toad venom , by mammalian kallikrein and salivary proteases .
2596504	0	mazindol	86,94	growth_hormone	20,34	mazindol	growth hormone	MESH:D008454	2688	Chemical	Gene	cyproheptadine|amod|START_ENTITY doses|nmod|cyproheptadine effect|nmod|doses rhythm|dep|effect rhythm|nmod|END_ENTITY	Nocturnal rhythm of growth_hormone in Duchenne patients : effect of different doses of mazindol and/or cyproheptadine .
3221222	0	mazindol	14,22	growth_hormone	26,40	mazindol	growth hormone	MESH:D008454	2688	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|amod|END_ENTITY	The effect of mazindol on growth_hormone secretion in boys with Duchenne_muscular_dystrophy .
3239574	0	mazindol	10,18	growth_hormone	22,36	mazindol	growth hormone	MESH:D008454	2688	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|amod|END_ENTITY	Effect of mazindol on growth_hormone levels in patients with Duchenne_muscular_dystrophy .
6582324	0	mechlorethamine	11,26	HN2	28,31	mechlorethamine	HN2	MESH:D008466	100462981	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of mechlorethamine -LRB- HN2 , nitrogen mustard -RRB- on UV-induced carcinogenesis in hairless mouse skin .
4705708	0	mechlorethamine	15,30	albumin	68,75	mechlorethamine	albumin	MESH:D008466	24186(Tax:10116)	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of mechlorethamine and isophosphamide with bovine serum albumin and rat liver microsomes .
11223577	0	mechlorethamine	17,32	ecto-ATPase	52,63	mechlorethamine	ecto-ATPase	MESH:D008466	81613(Tax:10116)	Chemical	Gene	influence|nmod|START_ENTITY influence|nmod|activity activity|nmod|END_ENTITY	The influence of mechlorethamine on the activity of ecto-ATPase of rat lymphocytes .
956343	0	meclastine	36,46	growth_hormone	96,110	meclastine	growth hormone	MESH:D002974	2688	Chemical	Gene	START_ENTITY|nmod|response response|nmod|END_ENTITY	Effect of the antihistaminic agents meclastine and dexchlorpheniramine on the response of human growth_hormone to arginine infusion and insulin hypoglycemia .
21131266	0	meclizine	23,32	pregnane_X_receptor	58,77	meclizine	pregnane X receptor	MESH:D008468	84385(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|nmod|END_ENTITY	Differential effect of meclizine on the activity of human pregnane_X_receptor and constitutive_androstane_receptor .
6383082	0	meclofenamate	11,24	renin	32,37	meclofenamate	renin	MESH:D008469	24715(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|response response|compound|END_ENTITY	Effects of meclofenamate on the renin response to aortic constriction in the rat .
26887269	0	mecobalamin	12,23	Bax	27,30	mecobalamin	Bax	MESH:C019476	24887(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of mecobalamin on Bax and Bcl-2 in neurons after peripheral_nerve_injury -RSB- .
9401696	0	medetomidine	11,23	insulin	33,40	medetomidine	insulin	MESH:D020926	483665(Tax:9615)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of medetomidine on serum insulin and plasma glucose concentrations in clinically normal dogs .
11148466	0	mediastinum	54,65	terminal_deoxynucleotidyl_transferase	71,108	mediastinum	terminal deoxynucleotidyl transferase	null	1791	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Blastic natural killer cell lymphoma arising from the mediastinum with terminal_deoxynucleotidyl_transferase expression .
3595069	0	medroxalol	12,22	prolactin	34,43	medroxalol	prolactin	MESH:C024892	5617	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|compound|END_ENTITY	Intravenous medroxalol stimulates prolactin secretion in normal and hypertensive subjects .
557353	0	medroxy-progesterone_acetate	28,56	prolactin	15,24	medroxy-progesterone acetate	prolactin	MESH:D017258	5617	Chemical	Gene	release|nmod|START_ENTITY release|nmod|END_ENTITY	The release of prolactin by medroxy-progesterone_acetate in human subjects .
5790396	0	medroxyprogesterone	69,88	Growth_hormone	0,14	medroxyprogesterone	Growth hormone	MESH:D008525	2688	Chemical	Gene	effect|nmod|START_ENTITY secretion|dep|effect secretion|amod|END_ENTITY	Growth_hormone secretion in idiopathic_precocious_puberty : effect of medroxyprogesterone .
23658782	0	medroxyprogesterone_acetate	33,60	CD4	141,144	medroxyprogesterone acetate	CD4	MESH:D017258	920	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|apoptosis apoptosis|nmod|cells cells|compound|END_ENTITY	The progestin-only contraceptive medroxyprogesterone_acetate , but not norethisterone_acetate , enhances HIV-1 Vpr-mediated apoptosis in human CD4 + T cells through the glucocorticoid_receptor .
6235158	0	medroxyprogesterone_acetate	60,87	apolipoprotein_AI	11,28	medroxyprogesterone acetate	apolipoprotein AI	MESH:D017258	335	Chemical	Gene	Changes|nmod|START_ENTITY Changes|nmod|END_ENTITY	Changes in apolipoprotein_AI after treatment with high-dose medroxyprogesterone_acetate .
21047628	0	medroxyprogesterone_acetate	60,87	glucocorticoid_receptor	8,31	medroxyprogesterone acetate	glucocorticoid receptor	MESH:D017258	2908	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nmod|effect	Role of glucocorticoid_receptor in the inhibitory effect of medroxyprogesterone_acetate on the estrogen-induced endothelial nitric_oxide synthase phosphorylation in human umbilical vein endothelial cells .
23658782	0	medroxyprogesterone_acetate	33,60	glucocorticoid_receptor	166,189	medroxyprogesterone acetate	glucocorticoid receptor	MESH:D017258	2908	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	The progestin-only contraceptive medroxyprogesterone_acetate , but not norethisterone_acetate , enhances HIV-1 Vpr-mediated apoptosis in human CD4 + T cells through the glucocorticoid_receptor .
24840644	0	medroxyprogesterone_acetate	34,61	glucocorticoid_receptor	170,193	medroxyprogesterone acetate	glucocorticoid receptor	MESH:D017258	2908	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|cells cells|nmod|END_ENTITY	The injectable-only contraceptive medroxyprogesterone_acetate , unlike norethisterone_acetate and progesterone , regulates inflammatory genes in endocervical cells via the glucocorticoid_receptor .
9822358	0	medroxyprogesterone_acetate	21,48	granulocyte_macrophage-colony_stimulating_factor	63,111	medroxyprogesterone acetate	granulocyte macrophage-colony stimulating factor	MESH:D017258	1437	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Effects of high dose medroxyprogesterone_acetate on endogenous granulocyte_macrophage-colony_stimulating_factor secretion and bone marrow cellularity in patients under cytotoxic chemotherapy .
6458192	0	medroxyprogesterone_acetate	13,40	growth_hormone	61,75	medroxyprogesterone acetate	growth hormone	MESH:D017258	403795(Tax:9615)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|levels levels|compound|END_ENTITY	Influence of medroxyprogesterone_acetate -LRB- Provera -RRB- on plasma growth_hormone levels and on carbohydrate metabolism .
6458193	0	medroxyprogesterone_acetate	13,40	growth_hormone	61,75	medroxyprogesterone acetate	growth hormone	MESH:D017258	403795(Tax:9615)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|levels levels|compound|END_ENTITY	Influence of medroxyprogesterone_acetate -LRB- Provera -RRB- on plasma growth_hormone levels and on carbohydrate metabolism .
10535399	0	medroxyprogesterone_acetate	21,48	insulin-like_growth_factor-1	83,111	medroxyprogesterone acetate	insulin-like growth factor-1	MESH:D017258	3479	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|role role|nmod|END_ENTITY	Effect of short-term medroxyprogesterone_acetate on left_ventricular_mass : role of insulin-like_growth_factor-1 .
14567291	0	medroxyprogesterone_acetate	47,74	interleukin-2	13,26	medroxyprogesterone acetate	interleukin-2	MESH:D017258	3558	Chemical	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	Subcutaneous interleukin-2 in combination with medroxyprogesterone_acetate and antioxidants in advanced cancer responders to previous chemotherapy : phase II study evaluating clinical , quality of life , and laboratory parameters .
10971177	0	medroxyprogesterone_acetate	65,92	interleukin-6	21,34	medroxyprogesterone acetate	interleukin-6	MESH:D017258	3569	Chemical	Gene	benefits|nmod|START_ENTITY predict|dobj|benefits analysis|acl|predict analysis|nmod|levels levels|amod|END_ENTITY	An analysis of serum interleukin-6 levels to predict benefits of medroxyprogesterone_acetate in advanced or recurrent breast_cancer .
16989825	0	medroxyprogesterone_acetate	60,87	interleukin-6	25,38	medroxyprogesterone acetate	interleukin-6	MESH:D017258	3569	Chemical	Gene	suppression|nmod|START_ENTITY suppression|nmod|END_ENTITY	Decreased suppression of interleukin-6 after treatment with medroxyprogesterone_acetate and danazol in endometrial stromal cells of women with adenomyosis .
7473894	0	medroxyprogesterone_acetate	11,38	interleukin-6	61,74	medroxyprogesterone acetate	interleukin-6	MESH:D017258	24498(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|production production|amod|END_ENTITY	Effects of medroxyprogesterone_acetate and beta-estradiol on interleukin-6 production from osteoblasts and bone marrow macrophages of Wistar_rats of different ages .
11084179	0	medroxyprogesterone_acetate	6,33	prolactin	50,59	medroxyprogesterone acetate	prolactin	MESH:D017258	5617	Chemical	Gene	START_ENTITY|dobj|levels levels|compound|END_ENTITY	Depot medroxyprogesterone_acetate and basal serum prolactin levels in lactating women .
3212009	0	medroxyprogesterone_acetate	11,38	prolactin	75,84	medroxyprogesterone acetate	prolactin	MESH:D017258	24683(Tax:10116)	Chemical	Gene	levels|amod|START_ENTITY Effects|nmod|levels END_ENTITY|nsubj|Effects	Effects of medroxyprogesterone_acetate on serum prolactin levels and liver prolactin binding capacity in the rat .
803668	0	medroxyprogesterone_acetate	51,78	prolactin	8,17	medroxyprogesterone acetate	prolactin	MESH:D017258	5617	Chemical	Gene	treatment|compound|START_ENTITY women|nmod|treatment release|nmod|women release|nsubj|END_ENTITY	Induced prolactin release in women under long-term medroxyprogesterone_acetate treatment .
810369	0	medroxyprogesterone_acetate	50,77	prolactin	18,27	medroxyprogesterone acetate	prolactin	MESH:D017258	5617	Chemical	Gene	using|dobj|START_ENTITY levels|acl|using levels|compound|END_ENTITY	Stimulated plasma prolactin levels in women using medroxyprogesterone_acetate or an intrauterine device for contraception .
6460678	0	medroxyprogesterone_acetate	10,37	renin	65,70	medroxyprogesterone acetate	renin	MESH:D017258	5972	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|compound|END_ENTITY	Effect of medroxyprogesterone_acetate and d-norgestrel on plasma renin activity , antidiuretic hormone , and urinary aldosterone in postmenopausal women .
9625372	0	medroxyprogesterone_acetate	10,37	sex_hormone-binding_globulin	41,69	medroxyprogesterone acetate	sex hormone-binding globulin	MESH:D017258	6462	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of medroxyprogesterone_acetate on sex_hormone-binding_globulin mRNA expression in the human endometrial_cancer cell line Ishikawa .
9373794	0	medroxyprogesterone_acetate	20,47	tumor_necrosis_factor-alpha	51,78	medroxyprogesterone acetate	tumor necrosis factor-alpha	MESH:D017258	7124	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|release release|amod|END_ENTITY	Effect of high-dose medroxyprogesterone_acetate on tumor_necrosis_factor-alpha release in patients with chemotherapy-induced neutropenia .
9124995	0	mefloquine	11,21	Ca2	25,28	mefloquine	Ca2	MESH:D015767	477928(Tax:9615)	Chemical	Gene	START_ENTITY|nmod|+ +|amod|END_ENTITY	Effects of mefloquine on Ca2 + uptake and release by dog brain microsomes .
11751128	0	mefloquine	45,55	Pfmdr1	0,6	mefloquine	Pfmdr1	MESH:D015767	813045(Tax:36329)	Chemical	Gene	treatment|compound|START_ENTITY END_ENTITY|nmod|treatment	Pfmdr1 alleles and response to ultralow-dose mefloquine treatment in Gabonese patients .
10586912	0	mefloquine	12,22	pfmdr1	55,61	mefloquine	pfmdr1	MESH:D015767	813045(Tax:36329)	Chemical	Gene	resistance|amod|START_ENTITY resistance|nmod|END_ENTITY	Analysis of mefloquine resistance and amplification of pfmdr1 in multidrug-resistant Plasmodium_falciparum isolates from Thailand .
10802315	0	mefloquine	130,140	pfmdr1	30,36	mefloquine	pfmdr1	MESH:D015767	813045(Tax:36329)	Chemical	Gene	sensitivity|nmod|START_ENTITY associated|nmod|sensitivity associated|nsubjpass|allele allele|nmod|gene gene|amod|END_ENTITY	The tyrosine-86 allele of the pfmdr1 gene of Plasmodium_falciparum is associated with increased sensitivity to the anti-malarials mefloquine and artemisinin .
10844681	0	mefloquine	43,53	pfmdr1	103,109	mefloquine	pfmdr1	MESH:D015767	813045(Tax:36329)	Chemical	Gene	sensitivity|nmod|START_ENTITY conferred|nsubjpass|sensitivity conferred|nmod|mutations mutations|nmod|gene gene|amod|END_ENTITY	Increased sensitivity to the antimalarials mefloquine and artemisinin is conferred by mutations in the pfmdr1 gene of Plasmodium_falciparum .
12557835	0	mefloquine	22,32	pfmdr1	143,149	mefloquine	pfmdr1	MESH:D015767	813045(Tax:36329)	Chemical	Gene	outcome|compound|START_ENTITY outcome|nmod|mutations mutations|nmod|gene gene|compound|END_ENTITY	Lack of prediction of mefloquine and mefloquine-artesunate treatment outcome by mutations in the Plasmodium_falciparum multidrug resistance 1 -LRB- pfmdr1 -RRB- gene for P. _ falciparum_malaria in Peru .
16845638	0	mefloquine	91,101	pfmdr1	11,17	mefloquine	pfmdr1	MESH:D015767	813045(Tax:36329)	Chemical	Gene	heightens|advcl|START_ENTITY heightens|csubj|Decreasing Decreasing|dobj|number number|amod|END_ENTITY	Decreasing pfmdr1 copy number in plasmodium_falciparum malaria heightens susceptibility to mefloquine , lumefantrine , halofantrine , quinine , and artemisinin .
20668121	0	mefloquine	60,70	pfmdr1	0,6	mefloquine	pfmdr1	MESH:D015767	813045(Tax:36329)	Chemical	Gene	associated|xcomp|START_ENTITY amplification|acl|associated amplification|amod|END_ENTITY	pfmdr1 amplification associated with clinical resistance to mefloquine in West Africa : implications for efficacy of artemisinin combination therapies .
25049252	8	mefloquine	1679,1689	pfmdr1	1807,1813	mefloquine	pfmdr1	MESH:D015767	813045(Tax:36329)	Chemical	Gene	associated|nmod|START_ENTITY had|ccomp|associated had|dobj|amplification amplification|nmod|mutation mutation|amod|END_ENTITY	Isolates had mutations associated with clinical resistance to mefloquine , with 35 % prevalence of P. _ falciparum multidrug resistance gene 1 -LRB- pfmdr1 -RRB- amplification and 84.5 % occurrence of the pfmdr1 Y184F mutation .
8302844	0	mefloquine	14,24	pfmdr1	95,101	mefloquine	pfmdr1	MESH:D015767	813045(Tax:36329)	Chemical	Gene	resistance|amod|START_ENTITY Selection|nmod|resistance linked|nsubj|Selection linked|nmod|amplification amplification|nmod|gene gene|amod|END_ENTITY	Selection for mefloquine resistance in Plasmodium_falciparum is linked to amplification of the pfmdr1 gene and cross-resistance to halofantrine and quinine .
8823246	0	mefloquine	97,107	pfmdr1	59,65	mefloquine	pfmdr1	MESH:D015767	813045(Tax:36329)	Chemical	Gene	resistance|compound|START_ENTITY necessary|nmod|resistance necessary|nsubj|amplification amplification|nmod|END_ENTITY	Plasmodium_falciparum : amplification and overexpression of pfmdr1 is not necessary for increased mefloquine resistance .
8675357	0	megestrol	9,18	albumin	35,42	megestrol	albumin	MESH:D008535	213	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Low dose megestrol increases serum albumin in malnourished dialysis patients .
9379696	0	megestrol_acetate	52,69	Prostate-specific_antigen	0,25	megestrol acetate	Prostate-specific antigen	MESH:D019290	354	Chemical	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Prostate-specific_antigen response to withdrawal of megestrol_acetate in a patient with hormone-refractory_prostate_cancer .
19218044	0	megestrol_acetate	10,27	albumin	37,44	megestrol acetate	albumin	MESH:D019290	213	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|level level|compound|END_ENTITY	Effect of megestrol_acetate on serum albumin level in malnourished dialysis patients .
10091767	0	megestrol_acetate	59,76	prostate_specific_antigen	27,52	megestrol acetate	prostate specific antigen	MESH:D019290	354	Chemical	Gene	treatment|amod|START_ENTITY END_ENTITY|nmod|treatment	Prognostic value of plasma prostate_specific_antigen after megestrol_acetate treatment in patients with metastatic breast_carcinoma .
6434315	5	megestrol_acetate	1215,1232	tamoxifen	1202,1211	megestrol acetate	prolactin	MESH:D019290	5617	Chemical	Gene	treatment|amod|START_ENTITY END_ENTITY|nmod|treatment	The results show that addition of tamoxifen to megestrol_acetate treatment annihilated the hyper-response of prolactin to TRH stimulation , while basal prolactin levels remained unaffected .
20929197	0	meiogynin_A	30,41	Bcl-xL	59,65	meiogynin A	Bcl-xL	MESH:C548770	598	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Biomimetic total synthesis of meiogynin_A , an inhibitor of Bcl-xL and Bak interaction .
25266781	0	meiogynin_A	14,25	Bcl-xL	50,56	meiogynin A	Bcl-xL	MESH:C548770	598	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|dep|END_ENTITY	Pro-apoptotic meiogynin_A derivatives that target Bcl-xL and Mcl-1 .
11858482	0	melagatran	101,111	THRombin	232,240	melagatran	THRombin	MESH:C109573	2147	Chemical	Gene	study|appos|START_ENTITY study|dep|MElagatran MElagatran|nmod|inhibition inhibition|amod|END_ENTITY	A dose-ranging study of the oral direct thrombin inhibitor , ximelagatran , and its subcutaneous form , melagatran , compared with dalteparin in the prophylaxis of thromboembolism after hip or knee replacement : METHRO I. MElagatran for THRombin inhibition in Orthopaedic surgery .
17405786	0	melagatran	25,35	Thrombin	0,8	melagatran	Thrombin	MESH:C109573	29251(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Thrombin inhibition with melagatran does not attenuate renal ischaemia-reperfusion injury in rats .
10102460	0	melagatran	41,51	thrombin	75,83	melagatran	thrombin	MESH:C109573	2147	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Pharmacokinetics and pharmacodynamics of melagatran , a novel synthetic LMW thrombin inhibitor , in patients with acute DVT .
10669267	0	melagatran	11,21	thrombin	39,47	melagatran	thrombin	MESH:C109573	100144442(Tax:9823)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|inhibitor inhibitor|nmod|END_ENTITY	Effects of melagatran , an inhibitor of thrombin , on fibrin deposits , haemodynamics , and platelet count in endotoxaemic pigs .
11060733	0	melagatran	11,21	thrombin	38,46	melagatran	thrombin	MESH:C109573	2147	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Effects of melagatran , a novel direct thrombin inhibitor , during experimental septic_shock .
11820295	0	melagatran	17,27	thrombin	45,53	melagatran	thrombin	MESH:C109573	2147	Chemical	Gene	Determination|nmod|START_ENTITY Determination|appos|inhibitor inhibitor|compound|END_ENTITY	Determination of melagatran , a novel , direct thrombin inhibitor , in human plasma and urine by liquid chromatography-mass spectrometry .
11858482	0	melagatran	101,111	thrombin	40,48	melagatran	thrombin	MESH:C109573	2147	Chemical	Gene	study|appos|START_ENTITY study|nmod|inhibitor inhibitor|compound|END_ENTITY	A dose-ranging study of the oral direct thrombin inhibitor , ximelagatran , and its subcutaneous form , melagatran , compared with dalteparin in the prophylaxis of thromboembolism after hip or knee replacement : METHRO I. MElagatran for THRombin inhibition in Orthopaedic surgery .
12739985	0	melagatran	78,88	thrombin	156,164	melagatran	thrombin	MESH:C109573	2147	Chemical	Gene	influence|nmod|START_ENTITY influence|nmod|administration administration|nmod|ximelagatran ximelagatran|appos|inhibitor inhibitor|compound|END_ENTITY	No influence of ethnic origin on the pharmacokinetics and pharmacodynamics of melagatran following oral administration of ximelagatran , a novel oral direct thrombin inhibitor , to healthy male volunteers .
12739986	0	melagatran	72,82	thrombin	119,127	melagatran	thrombin	MESH:C109573	2147	Chemical	Gene	START_ENTITY|appos|form form|nmod|ximelagatran ximelagatran|compound|END_ENTITY	No influence of obesity on the pharmacokinetics and pharmacodynamics of melagatran , the active form of the oral direct thrombin inhibitor ximelagatran .
12845508	0	melagatran	41,51	thrombin	88,96	melagatran	thrombin	MESH:C109573	2147	Chemical	Gene	Pharmacokinetics|nmod|START_ENTITY Pharmacokinetics|appos|form form|nmod|ximelagatran ximelagatran|compound|END_ENTITY	Pharmacokinetics and pharmacodynamics of melagatran , the active form of the oral direct thrombin inhibitor ximelagatran , are not influenced by acetylsalicylic_acid .
12973822	0	melagatran	31,41	thrombin	52,60	melagatran	thrombin	MESH:C109573	29251(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Three vehicle formulations for melagatran , a direct thrombin inhibitor , evaluated in a vena cava thrombosis model in the rat .
14517494	0	melagatran	75,85	thrombin	56,64	melagatran	thrombin	MESH:C109573	2147	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|Pharmacokinetics Pharmacokinetics|nmod|END_ENTITY	Pharmacokinetics and anticoagulant effect of the direct thrombin inhibitor melagatran following subcutaneous administration to healthy young men .
15081569	0	melagatran	25,35	thrombin	155,163	melagatran	thrombin	MESH:C109573	2147	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|generation generation|compound|END_ENTITY	The inhibitory effect of melagatran , the active form of the oral direct thrombin inhibitor ximelagatran , compared with enoxaparin and r-hirudin on ex vivo thrombin generation in human plasma .
15081569	0	melagatran	25,35	thrombin	72,80	melagatran	thrombin	MESH:C109573	2147	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|form form|nmod|ximelagatran ximelagatran|compound|END_ENTITY	The inhibitory effect of melagatran , the active form of the oral direct thrombin inhibitor ximelagatran , compared with enoxaparin and r-hirudin on ex vivo thrombin generation in human plasma .
15567465	0	melagatran	24,34	thrombin	71,79	melagatran	thrombin	MESH:C109573	2147	Chemical	Gene	action|nmod|START_ENTITY action|appos|form form|nmod|ximelagatran ximelagatran|compound|END_ENTITY	Anticoagulant action of melagatran , the active form of the oral direct thrombin inhibitor ximelagatran , in umbilical cord and adult plasma : an in vitro examination .
16430313	0	melagatran	52,62	thrombin	140,148	melagatran	thrombin	MESH:C109573	2147	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY pharmacokinetics|nmod|administration administration|nmod|ximelagatran ximelagatran|compound|END_ENTITY	Comparable pharmacokinetics and pharmacodynamics of melagatran in Japanese and caucasian volunteers after oral administration of the direct thrombin inhibitor ximelagatran .
16884319	0	melagatran	31,41	thrombin	78,86	melagatran	thrombin	MESH:C109573	2147	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY pharmacokinetics|appos|form form|nmod|ximelagatran ximelagatran|compound|END_ENTITY	Population pharmacokinetics of melagatran , the active form of the oral direct thrombin inhibitor ximelagatran , in atrial_fibrillation patients receiving long-term anticoagulation therapy .
17068159	0	melagatran	36,46	thrombin	11,19	melagatran	thrombin	MESH:C109573	29251(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|Effects Effects|nmod|END_ENTITY	Effects of thrombin inhibition with melagatran on renal hemodynamics and function and liver integrity during early endotoxemia .
18064315	0	melagatran	58,68	thrombin	39,47	melagatran	thrombin	MESH:C109573	2147	Chemical	Gene	heparin|amod|START_ENTITY inhibitor|dobj|heparin inhibitor|nsubj|activity activity|nmod|END_ENTITY	Profibrinolytic activity of the direct thrombin inhibitor melagatran and unfractionated heparin in platelet-poor and platelet-rich clots .
26188924	0	melagatran	96,106	thrombin	117,125	melagatran	thrombin	MESH:C109573	2147	Chemical	Gene	Paradoxical|nmod|START_ENTITY Paradoxical|dobj|inhibitor inhibitor|compound|END_ENTITY	Paradoxical enhancement of the intrinsic pathway-induced thrombin_generation in human plasma by melagatran , a direct thrombin inhibitor , but not edoxaban , a direct factor Xa inhibitor , or heparin .
9459334	0	melagatran	11,21	thrombin	50,58	melagatran	thrombin	MESH:C109573	29251(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Effects of melagatran , a new low-molecular-weight thrombin inhibitor , on thrombin and fibrinolytic enzymes .
9459334	0	melagatran	11,21	thrombin	73,81	melagatran	thrombin	MESH:C109573	29251(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|enzymes enzymes|amod|END_ENTITY	Effects of melagatran , a new low-molecular-weight thrombin inhibitor , on thrombin and fibrinolytic enzymes .
10876051	1	melanocortin	200,212	MC3R	224,228	melanocortin	AGRP	null	181	Chemical	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Agouti-related_protein -LRB- AGRP -RRB- is a naturally occurring antagonist of the brain melanocortin receptors -LRB- MC3R and MC4R -RRB- and is physiologically implicated as participating in feeding behavior and energy homeostasis .
17243703	0	melanoidins	62,73	Angiotensin-I_converting_enzyme	0,31	melanoidins	Angiotensin-I converting enzyme	null	1636	Chemical	Gene	START_ENTITY|nsubj|activity activity|amod|END_ENTITY	Angiotensin-I_converting_enzyme inhibitory activity of coffee melanoidins .
21963392	0	melatonin	13,22	AR	78,80	melatonin	AR	MESH:D008550	367	Chemical	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Variation in melatonin receptors -LRB- Mel -LRB- 1a -RRB- and Mel -LRB- 1b -RRB- -RRB- and androgen_receptor -LRB- AR -RRB- expression in the spleen of a seasonally breeding bird , Perdicula asiatica .
23701823	6	melatonin	972,981	BMP-4	1015,1020	melatonin	BMP-4	MESH:D008550	12159(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	Treatment with melatonin or ramelteon in combination with BMP-4 additively suppressed CRH-induced ACTH production .
15205854	0	melatonin	15,24	Bax	93,96	melatonin	Bax	MESH:D008550	24887(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	The effects of melatonin and the antioxidant defence system on apoptosis regulator proteins -LRB- Bax and Bcl-2 -RRB- in experimentally induced varicocele .
9185671	0	melatonin	203,212	CREB	107,111	melatonin	CREB	MESH:D008550	81646(Tax:10116)	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|phosphorylation phosphorylation|nmod|END_ENTITY	The pituitary_adenylate_cyclase-activating_polypeptide-induced phosphorylation of the transcription factor CREB -LRB- cAMP_response_element_binding_protein -RRB- in the rat suprachiasmatic_nucleus is inhibited by melatonin .
11703563	0	melatonin	52,61	CYP1A2	16,22	melatonin	CYP1A2	MESH:D008550	24297(Tax:10116)	Chemical	Gene	metabolism|nmod|START_ENTITY END_ENTITY|nmod|metabolism	Contribution of CYP1A2 in the hepatic metabolism of melatonin : studies with isolated microsomal preparations and liver slices .
18490497	0	melatonin	61,70	CYP1A2	96,102	melatonin	CYP1A2	MESH:D008550	1544	Chemical	Gene	START_ENTITY|nmod|subjects subjects|nmod|END_ENTITY	The effect of oral contraceptives on the pharmacokinetics of melatonin in healthy subjects with CYP1A2 g.-163C > A polymorphism .
15037034	0	melatonin	86,95	Caspase-3	0,9	melatonin	Caspase-3	MESH:D008550	25402(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|dep|effect	Caspase-3 and heat_shock_protein-70 in rat liver treated with aflatoxin_B1 : effect of melatonin .
20404168	0	melatonin	59,68	Clock	37,42	melatonin	Clock	MESH:D008550	12753(Tax:10090)	Chemical	Gene	mutation|nmod|START_ENTITY mutation|compound|END_ENTITY	Genetic suppression of the circadian Clock mutation by the melatonin biosynthesis pathway .
9143000	0	melatonin	41,50	Corticotropin-releasing_hormone	0,31	melatonin	Corticotropin-releasing hormone	MESH:D008550	1392	Chemical	Gene	secretion|compound|START_ENTITY secretion|amod|END_ENTITY	Corticotropin-releasing_hormone inhibits melatonin secretion in healthy volunteers -- a potential link to low-melatonin_syndrome in depression ?
20825493	0	melatonin	65,74	Cry1	85,89	melatonin	Cry1	MESH:D008550	12952(Tax:10090)	Chemical	Gene	levels|compound|START_ENTITY Loss|nmod|levels Loss|nmod|END_ENTITY	Loss of circadian rhythm and light-induced suppression of pineal melatonin levels in Cry1 and Cry2 double-deficient mice .
20854829	0	melatonin	38,47	Endothelin-1	0,12	melatonin	Endothelin-1	MESH:D008550	24323(Tax:10116)	Chemical	Gene	marker|nmod|START_ENTITY END_ENTITY|nmod|marker	Endothelin-1 as a potential marker of melatonin 's therapeutic effects in smoking-induced vasculopathy .
9723886	0	melatonin	66,75	Estrogen_receptor	0,17	melatonin	Estrogen receptor	MESH:D008550	2099	Chemical	Gene	factors|compound|START_ENTITY transactivation|nmod|factors transactivation|nsubj|END_ENTITY	Estrogen_receptor transactivation in MCF-7 breast_cancer cells by melatonin and growth factors .
11930164	0	melatonin	37,46	GDNF	13,17	melatonin	GDNF	MESH:D008550	25453(Tax:10116)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|expression expression|compound|END_ENTITY	Induction of GDNF mRNA expression by melatonin in rat C6 glioma cells .
11095532	0	melatonin	67,76	GTP_cyclohydrolase_I	19,39	melatonin	GTP cyclohydrolase I	MESH:D008550	14528(Tax:10090)	Chemical	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|nmod|END_ENTITY	Down-regulation of GTP_cyclohydrolase_I and tetrahydrobiopterin by melatonin .
25687675	0	melatonin	80,89	Ghrelin	0,7	melatonin	Ghrelin	MESH:D008550	59301(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY expression|dep|role expression|compound|END_ENTITY	Ghrelin gene expression in rats with ethanol-induced gastric_ulcers : a role of melatonin .
12734775	0	melatonin	41,50	Gonadotropin-releasing_hormone	0,30	melatonin	Gonadotropin-releasing hormone	MESH:D008550	25194(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|increases increases|amod|END_ENTITY	Gonadotropin-releasing_hormone increases melatonin release in the pineal gland of the female rat in vitro .
27062045	0	melatonin	33,42	H19	20,23	melatonin	H19	MESH:D008550	283120	Chemical	Gene	inhibition|compound|START_ENTITY mediates|dobj|inhibition mediates|nsubj|END_ENTITY	Long non-coding RNA H19 mediates melatonin inhibition of premature senescence of c-kit -LRB- + -RRB- cardiac progenitor cells by promoting miR-675 .
26184924	0	melatonin	20,29	HDAC1	0,5	melatonin	HDAC1	MESH:D008550	3065	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nummod|END_ENTITY	HDAC1 inhibition by melatonin leads to suppression_of_lung_adenocarcinoma cells via induction of oxidative stress and activation of apoptotic pathways .
7722866	0	melatonin	21,30	IFN_gamma	48,57	melatonin	IFN gamma	MESH:D008550	3458	Chemical	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	Inhibitory effect of melatonin on production of IFN_gamma or TNF_alpha in peripheral blood mononuclear cells of some blood donors .
11268366	0	melatonin	68,77	IL-2	49,53	melatonin	IL-2	MESH:D008550	3558	Chemical	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	Involvement of nuclear receptors in the enhanced IL-2 production by melatonin in Jurkat cells .
8208518	0	melatonin	65,74	IL-2	113,117	melatonin	IL-2	MESH:D008550	3558	Chemical	Gene	Efficacy|nmod|START_ENTITY Efficacy|nmod|END_ENTITY	Efficacy of the concomitant administration of the pineal hormone melatonin in cancer immunotherapy with low-dose IL-2 in patients with advanced solid tumors who had progressed on IL-2 alone .
2121852	0	melatonin	27,36	Interferon-gamma	0,16	melatonin	Interferon-gamma	MESH:D008550	25712(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY production|amod|END_ENTITY	Interferon-gamma modulates melatonin production in rat pineal glands in organ culture .
23936817	0	melatonin	41,50	Leptin	0,6	melatonin	Leptin	MESH:D008550	25608(Tax:10116)	Chemical	Gene	synthesis|compound|START_ENTITY modulates|dobj|synthesis modulates|nsubj|END_ENTITY	Leptin modulates norepinephrine-mediated melatonin synthesis in cultured rat pineal gland .
7523585	0	melatonin	91,100	MAO-A	60,65	melatonin	MAO-A	MESH:D008550	29253(Tax:10116)	Chemical	Gene	inhibitors|nmod|START_ENTITY inhibitors|amod|END_ENTITY	Chronic effect of the irreversible and reversible selective MAO-A inhibitors on rat pineal melatonin biosynthesis .
10433507	0	melatonin	47,56	MT1	43,46	melatonin	MT1	MESH:D008550	24567(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Molecular and pharmacological evidence for MT1 melatonin receptor subtype in the tail artery of juvenile Wistar_rats .
11331072	0	melatonin	39,48	MT1	60,63	melatonin	MT1	MESH:D008550	644314	Chemical	Gene	receptors|compound|START_ENTITY studies|nmod|receptors studies|dep|END_ENTITY	Comparative pharmacological studies of melatonin receptors : MT1 , MT2 and MT3/QR2 .
11341973	0	melatonin	46,55	MT1	42,45	melatonin	MT1	MESH:D008550	17748(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|nummod|END_ENTITY	N1E-115 mouse neuroblastoma cells express MT1 melatonin receptors and produce neurites in response to melatonin .
11693175	0	melatonin	22,31	MT1	18,21	melatonin	MT1	MESH:D008550	644314	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Expression of the MT1 melatonin receptor subtype in human coronary arteries .
11897804	0	melatonin	16,25	MT1	26,29	melatonin	MT1	MESH:D008550	4543	Chemical	Gene	immunoreactivity|compound|START_ENTITY immunoreactivity|nummod|END_ENTITY	Distribution of melatonin MT1 receptor immunoreactivity in human retina .
12133595	0	melatonin	4,13	MT1	0,3	melatonin	MT1	MESH:D008550	24567(Tax:10116)	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	MT1 melatonin receptor mRNA expression exhibits a circadian variation in the rat suprachiasmatic nuclei .
12219788	0	melatonin	41,50	MT1	62,65	melatonin	MT1	MESH:D008550	644314	Chemical	Gene	receptors|compound|START_ENTITY expression|nmod|receptors expression|appos|END_ENTITY	Differential expression of high-affinity melatonin receptors -LRB- MT1 -RRB- in normal and malignant human breast tissue .
12445677	0	melatonin	26,35	MT1	22,25	melatonin	MT1	MESH:D008550	644314	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Overexpression of the MT1 melatonin receptor in MCF-7 human breast_cancer cells inhibits mammary tumor formation in nude_mice .
12732358	0	melatonin	56,65	MT1	52,55	melatonin	MT1	MESH:D008550	644314	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Important amino_acids for the function of the human MT1 melatonin receptor .
12743529	0	melatonin	4,13	MT1	0,3	melatonin	MT1	MESH:D008550	24567(Tax:10116)	Chemical	Gene	mRNA|amod|START_ENTITY mRNA|nummod|END_ENTITY	MT1 melatonin receptor mRNA tissular localization by PCR amplification .
12834439	0	melatonin	4,13	MT1	0,3	melatonin	MT1	MESH:D008550	24567(Tax:10116)	Chemical	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	MT1 melatonin receptor mRNA expressing cells in the pars tuberalis of the European hamster : effect of photoperiod .
14757166	0	melatonin	36,45	MT1	90,93	melatonin	MT1	MESH:D008550	56052	Chemical	Gene	receptor|compound|START_ENTITY pharmacology|nmod|receptor pharmacology|dep|comparison comparison|nmod|END_ENTITY	Molecular pharmacology of the ovine melatonin receptor : comparison with recombinant human MT1 and MT2 receptors .
15369705	0	melatonin	74,83	MT1	70,73	melatonin	MT1	MESH:D008550	644314	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Knock-down of RGS4 and beta tubulin in CHO cells expressing the human MT1 melatonin receptor prevents melatonin-induced receptor desensitization .
15511288	0	melatonin	26,35	MT1	94,97	melatonin	MT1	MESH:D008550	644314	Chemical	Gene	receptors|compound|START_ENTITY receptors|dep|colocalization colocalization|nmod|receptor receptor|compound|END_ENTITY	Neural stem cells express melatonin receptors and neurotrophic factors : colocalization of the MT1 receptor with neuronal and glial markers .
15620576	0	melatonin	30,39	MT1	18,21	melatonin	MT1	MESH:D008550	24567(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	The expression of MT1 and MT2 melatonin receptor mRNA in several rat tissues .
15952421	0	melatonin	25,34	MT1	21,24	melatonin	MT1	MESH:D008550	100294597(Tax:9940)	Chemical	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	Relationship between MT1 melatonin receptor gene polymorphism and seasonal physiological responses in Ile-de-France ewes .
15978051	0	melatonin	76,85	MT1	72,75	melatonin	MT1	MESH:D008550	644314	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	The functional role of cysteines adjacent to the NRY motif of the human MT1 melatonin receptor .
16098087	0	melatonin	14,23	MT1	10,13	melatonin	MT1	MESH:D008550	17748(Tax:10090)	Chemical	Gene	deletion|compound|START_ENTITY deletion|compound|END_ENTITY	Effect of MT1 melatonin receptor deletion on melatonin-mediated phase shift of circadian rhythms in the C57BL/6 mouse .
16098095	0	melatonin	144,153	MT1	140,143	melatonin	MT1	MESH:D008550	17748(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|nummod|END_ENTITY	The antidepressant-like effect of the melatonin receptor ligand luzindole in mice during forced swimming requires expression of MT2 but not MT1 melatonin receptors .
16217123	0	melatonin	23,32	MT1	11,14	melatonin	MT1	MESH:D008550	644314	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Functional MT1 and MT2 melatonin receptors in mammals .
16324119	0	melatonin	68,77	MT1	64,67	melatonin	MT1	MESH:D008550	17748(Tax:10090)	Chemical	Gene	signalling|compound|START_ENTITY signalling|nummod|END_ENTITY	Rhythms in clock proteins in the mouse pars tuberalis depend on MT1 melatonin receptor signalling .
16328061	0	melatonin	27,36	MT1	23,26	melatonin	MT1	MESH:D008550	644314	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Antiestrogens modulate MT1 melatonin receptor expression in breast and ovarian_cancer cell lines .
16879325	0	melatonin	28,37	MT1	47,50	melatonin	MT1	MESH:D008550	24567(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY expression|nmod|receptor END_ENTITY|nsubj|expression	Heterogeneous expression of melatonin receptor MT1 mRNA in the rat intestine under control and fasting conditions .
17072839	0	melatonin	20,29	MT1	121,124	melatonin	MT1	MESH:D008550	644314	Chemical	Gene	immunoreactivity|compound|START_ENTITY Distribution|nmod|immunoreactivity Distribution|dep|colocalization colocalization|nmod|END_ENTITY	Distribution of MT1 melatonin receptor immunoreactivity in the human hypothalamus and pituitary gland : colocalization of MT1 with vasopressin , oxytocin , and corticotropin-releasing_hormone .
17072839	0	melatonin	20,29	MT1	16,19	melatonin	MT1	MESH:D008550	644314	Chemical	Gene	immunoreactivity|compound|START_ENTITY immunoreactivity|compound|END_ENTITY	Distribution of MT1 melatonin receptor immunoreactivity in the human hypothalamus and pituitary gland : colocalization of MT1 with vasopressin , oxytocin , and corticotropin-releasing_hormone .
17342341	0	melatonin	15,24	MT1	11,14	melatonin	MT1	MESH:D008550	644314	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Effects of MT1 melatonin receptor overexpression on the aromatase-suppressive effect of melatonin in MCF-7 human breast_cancer cells .
17342341	0	melatonin	88,97	MT1	11,14	melatonin	MT1	MESH:D008550	644314	Chemical	Gene	effect|nmod|START_ENTITY overexpression|nmod|effect overexpression|nsubj|Effects Effects|nmod|receptor receptor|compound|END_ENTITY	Effects of MT1 melatonin receptor overexpression on the aromatase-suppressive effect of melatonin in MCF-7 human breast_cancer cells .
17762828	0	melatonin	35,44	MT1	61,64	melatonin	MT1	MESH:D008550	644314	Chemical	Gene	action|nmod|START_ENTITY Sites|nmod|action Sites|dep|END_ENTITY	-LSB- Sites and mechanisms of action of melatonin in mammals : the MT1 and MT2 receptors -RSB- .
17803522	0	melatonin	91,100	MT1	87,90	melatonin	MT1	MESH:D008550	644314	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Inverse agonist exposure enhances ligand binding and G protein activation of the human MT1 melatonin receptor , but leads to receptor down-regulation .
18039783	0	melatonin	38,47	MT1	34,37	melatonin	MT1	MESH:D008550	24567(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|functional functional|dep|END_ENTITY	Rhythmic expression of functional MT1 melatonin receptors in the rat adrenal gland .
18078453	0	melatonin	54,63	MT1	72,75	melatonin	MT1	MESH:D008550	24567(Tax:10116)	Chemical	Gene	pathways|nmod|START_ENTITY pathways|nmod|receptor receptor|nummod|END_ENTITY	Activation of insulin and IGF-1 signaling pathways by melatonin through MT1 receptor in isolated rat pancreatic islets .
18339124	0	melatonin	4,13	MT1	0,3	melatonin	MT1	MESH:D008550	644314	Chemical	Gene	internalization|amod|START_ENTITY internalization|nummod|END_ENTITY	MT1 melatonin receptor internalization underlies melatonin-induced morphologic changes in Chinese_hamster ovary cells and these processes are dependent on Gi proteins , MEK_1 / 2 and microtubule modulation .
18798788	0	melatonin	82,91	MT1	23,26	melatonin	MT1	MESH:D008550	644314	Chemical	Gene	actions|nmod|START_ENTITY required|nmod|actions required|nsubjpass|END_ENTITY	The melatonin receptor MT1 is required for the differential regulatory actions of melatonin on neuronal ` clock ' gene expression in striatal neurons in vitro .
18979234	0	melatonin	22,31	MT1	18,21	melatonin	MT1	MESH:D008550	644314	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Alteration of the MT1 melatonin receptor gene and its expression in primary human breast_tumors and breast_cancer cell lines .
19223130	0	melatonin	20,29	MT1	39,42	melatonin	MT1	MESH:D008550	100294597(Tax:9940)	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Polymorphism of the melatonin receptor MT1 gene and its relationship with seasonal reproductive activity in the Sarda sheep breed .
19261884	0	melatonin	58,67	MT1	54,57	melatonin	MT1	MESH:D008550	17748(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Melatonin transmits photoperiodic signals through the MT1 melatonin receptor .
19706469	0	melatonin	87,96	MT1	83,86	melatonin	MT1	MESH:D008550	17748(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Melatonin modulates visual function and cell viability in the mouse retina via the MT1 melatonin receptor .
19837985	0	melatonin	5,14	MT1	1,4	melatonin	MT1	MESH:D008550	644314	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	-LSB- MT1 melatonin receptors and their role in the oncostatic action of melatonin -RSB- .
19846924	0	melatonin	22,31	MT1	18,21	melatonin	MT1	MESH:D008550	644314	Chemical	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	The expression of MT1 melatonin receptor and Ki-67 antigen in melanoma_malignum .
19966183	0	melatonin	4,13	MT1	0,3	melatonin	MT1	MESH:D008550	644314	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	MT1 melatonin receptors mediate somatic , behavioral , and reproductive neuroendocrine responses to photoperiod and melatonin in Siberian hamsters -LRB- Phodopus sungorus -RRB- .
20030540	0	melatonin	12,21	MT1	31,34	melatonin	MT1	MESH:D008550	644314	Chemical	Gene	receptor|compound|START_ENTITY Response|nmod|receptor END_ENTITY|nsubj|Response	Response of melatonin receptor MT1 in spleen of a tropical Indian rodent , Funambulus pennanti , to natural solar insolation and different photoperiodic conditions .
21211212	0	melatonin	19,28	MT1	29,32	melatonin	MT1	MESH:D008550	24567(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	-LSB- The expression of melatonin MT1 receptor in acute_necrotizing_pancreatitis rats and the protective effects of melatonin -RSB- .
21757639	0	melatonin	101,110	MT1	85,88	melatonin	MT1	MESH:D008550	24567(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|interaction interaction|nmod|END_ENTITY	Melatonin inhibits cholangiocyte hyperplasia in cholestatic rats by interaction with MT1 but not MT2 melatonin receptors .
21913972	0	melatonin	130,139	MT1	67,70	melatonin	MT1	MESH:D008550	17748(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY involved|nmod|effects involved|nsubjpass|END_ENTITY	Evidence that membrane-bound G protein-coupled melatonin receptors MT1 and MT2 are not involved in the neuroprotective effects of melatonin in focal cerebral_ischemia .
21913972	0	melatonin	47,56	MT1	67,70	melatonin	MT1	MESH:D008550	17748(Tax:10090)	Chemical	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	Evidence that membrane-bound G protein-coupled melatonin receptors MT1 and MT2 are not involved in the neuroprotective effects of melatonin in focal cerebral_ischemia .
21994366	0	melatonin	4,13	MT1	14,17	melatonin	MT1	MESH:D008550	17748(Tax:10090)	Chemical	Gene	axis|amod|START_ENTITY axis|compound|END_ENTITY	The melatonin MT1 receptor axis modulates mutant Huntingtin-mediated toxicity .
22445399	0	melatonin	84,93	MT1	80,83	melatonin	MT1	MESH:D008550	644314	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Expression of seasonality in Merinos d'Arles ewes of different genotypes at the MT1 melatonin receptor gene .
23357659	0	melatonin	15,24	MT1	35,38	melatonin	MT1	MESH:D008550	4543	Chemical	Gene	Alterations|nmod|START_ENTITY receptors|nsubj|Alterations receptors|dobj|END_ENTITY	Alterations of melatonin receptors MT1 and MT2 in the hypothalamic suprachiasmatic nucleus during depression .
24051358	0	melatonin	20,29	MT1	16,19	melatonin	MT1	MESH:D008550	17748(Tax:10090)	Chemical	Gene	promoter-driven|compound|START_ENTITY promoter-driven|nummod|END_ENTITY	Distribution of MT1 melatonin receptor promoter-driven RFP expression in the brains of BAC C3H/HeN transgenic_mice .
24228714	0	melatonin	12,21	MT1	0,3	melatonin	MT1	MESH:D008550	644314	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	MT1 and MT2 melatonin receptors : ligands , models , oligomers , and therapeutic potential .
24658054	0	melatonin	28,37	MT1	24,27	melatonin	MT1	MESH:D008550	24567(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY END_ENTITY|dobj|expression	Regulation of pituitary MT1 melatonin receptor expression by gonadotrophin-releasing_hormone -LRB- GnRH -RRB- and early_growth_response_factor-1 -LRB- Egr-1 -RRB- : in vivo and in vitro studies .
25200199	0	melatonin	24,33	MT1	20,23	melatonin	MT1	MESH:D008550	17748(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Genetic deletion of MT1 melatonin receptors alters spontaneous behavioral rhythms in male and female C57BL/6 mice .
25797281	0	melatonin	45,54	MT1	77,80	melatonin	MT1	MESH:D008550	24567(Tax:10116)	Chemical	Gene	agonists|compound|START_ENTITY agonists|nmod|receptor receptor|compound|END_ENTITY	In vitro comparison of duration of action of melatonin agonists on melatonin MT1 receptor : Possible link between duration of action and dissociation rate from receptor .
25797281	0	melatonin	45,54	MT1	77,80	melatonin	MT1	MESH:D008550	24567(Tax:10116)	Chemical	Gene	agonists|compound|START_ENTITY agonists|nmod|receptor receptor|compound|END_ENTITY	In vitro comparison of duration of action of melatonin agonists on melatonin MT1 receptor : Possible link between duration of action and dissociation rate from receptor .
25797281	0	melatonin	67,76	MT1	77,80	melatonin	MT1	MESH:D008550	24567(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	In vitro comparison of duration of action of melatonin agonists on melatonin MT1 receptor : Possible link between duration of action and dissociation rate from receptor .
25797281	0	melatonin	67,76	MT1	77,80	melatonin	MT1	MESH:D008550	24567(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	In vitro comparison of duration of action of melatonin agonists on melatonin MT1 receptor : Possible link between duration of action and dissociation rate from receptor .
26514267	0	melatonin	35,44	MT1	45,48	melatonin	MT1	MESH:D008550	644314	Chemical	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons .
27010900	0	melatonin	16,25	MT1	26,29	melatonin	MT1	MESH:D008550	24567(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Dynamics of the melatonin MT1 receptor in the rat parotid gland upon melatonin administration .
27010900	0	melatonin	69,78	MT1	26,29	melatonin	MT1	MESH:D008550	24567(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY parotid|nmod|administration parotid|nsubj|Dynamics Dynamics|nmod|receptor receptor|compound|END_ENTITY	Dynamics of the melatonin MT1 receptor in the rat parotid gland upon melatonin administration .
10455277	0	melatonin	53,62	MT2	49,52	melatonin	MT2	MESH:D008550	4502	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Ligand efficacy and potency at recombinant human MT2 melatonin receptors : evidence for agonist activity of some mt1-antagonists .
10884567	0	melatonin	30,39	MT2	93,96	melatonin	MT2	MESH:D008550	17750(Tax:10090)	Chemical	Gene	agonists|amod|START_ENTITY properties|nmod|agonists properties|dep|involvement involvement|nmod|receptors receptors|compound|END_ENTITY	Anxiolytic-like properties of melatonin receptor agonists in mice : involvement of mt1 and/or MT2 receptors in the regulation of emotional responsiveness .
11316328	0	melatonin	127,136	MT2	123,126	melatonin	MT2	MESH:D008550	4544	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Chimeric Galphaq subunits can distinguish the long form of the Xenopus Mel1c melatonin receptor from the mammalian mt1 and MT2 melatonin receptors .
11564683	0	melatonin	37,46	MT2	25,28	melatonin	MT2	MESH:D008550	4544	Chemical	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Functional expression of MT2 -LRB- Mel1b -RRB- melatonin receptors in human PAZ6 adipocytes .
15206776	0	melatonin	36,45	MT2	22,25	melatonin	MT2	MESH:D008550	4502	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|nummod|END_ENTITY	Strategies leading to MT2 selective melatonin receptor antagonists .
15266022	0	melatonin	34,43	MT2	124,127	melatonin	MT2	MESH:D008550	4502	Chemical	Gene	receptor|compound|START_ENTITY formation|nmod|receptor heterodimers|nsubj|formation heterodimers|nmod|properties properties|nmod|homodimers homodimers|nummod|END_ENTITY	Preferential formation of MT1/MT2 melatonin receptor heterodimers with distinct ligand interaction properties compared with MT2 homodimers .
15501061	0	melatonin	38,47	MT2	48,51	melatonin	MT2	MESH:D008550	4502	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|compound|END_ENTITY	Tetrahydroisoquinoline derivatives as melatonin MT2 receptor antagonists .
15522910	0	melatonin	180,189	MT2	34,37	melatonin	MT2	MESH:D008550	4502	Chemical	Gene	defining|nmod|START_ENTITY relevance|acl|defining receptors|dep|relevance receptors|nummod|END_ENTITY	Melatonin desensitizes endogenous MT2 melatonin receptors in the rat suprachiasmatic nucleus : relevance for defining the periods of sensitivity of the mammalian circadian clock to melatonin .
15522910	0	melatonin	38,47	MT2	34,37	melatonin	MT2	MESH:D008550	4502	Chemical	Gene	receptors|compound|START_ENTITY receptors|nummod|END_ENTITY	Melatonin desensitizes endogenous MT2 melatonin receptors in the rat suprachiasmatic nucleus : relevance for defining the periods of sensitivity of the mammalian circadian clock to melatonin .
15525337	0	melatonin	32,41	MT2	28,31	melatonin	MT2	MESH:D008550	4502	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Molecular modeling of human MT2 melatonin receptor : the role of Val204 , Leu272 and Tyr298 in ligand binding .
15913560	0	melatonin	32,41	MT2	28,31	melatonin	MT2	MESH:D008550	4502	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Ligand binding to the human MT2 melatonin receptor : the role of residues in transmembrane domains 3 , 6 , and 7 .
15943478	0	melatonin	78,87	MT2	49,52	melatonin	MT2	MESH:D008550	4502	Chemical	Gene	MT1|amod|START_ENTITY antagonists|nmod|MT1 antagonists|nummod|END_ENTITY	Analysis of structure-activity relationships for MT2 selective antagonists by melatonin MT1 and MT2 receptor models .
16098095	0	melatonin	38,47	MT2	128,131	melatonin	MT2	MESH:D008550	17750(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY effect|nmod|receptor ligand|nsubj|effect ligand|ccomp|requires requires|dobj|expression expression|nmod|END_ENTITY	The antidepressant-like effect of the melatonin receptor ligand luzindole in mice during forced swimming requires expression of MT2 but not MT1 melatonin receptors .
16203090	0	melatonin	47,56	MT2	57,60	melatonin	MT2	MESH:D008550	17750(Tax:10090)	Chemical	Gene	mice|compound|START_ENTITY mice|compound|END_ENTITY	Impaired hippocampal long-term potentiation in melatonin MT2 receptor-deficient mice .
16635021	0	melatonin	138,147	MT2	134,137	melatonin	MT2	MESH:D008550	4502	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Melatonin enhances alkaline_phosphatase activity in differentiating human adult mesenchymal stem cells grown in osteogenic medium via MT2 melatonin receptors and the MEK/ERK _ -LRB- 1/2 -RRB- signaling cascade .
17346886	0	melatonin	16,25	MT2	78,81	melatonin	MT2	MESH:D008550	689415(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|nmod|rats rats|nmod|activation activation|nmod|receptors receptors|compound|END_ENTITY	Oral and spinal melatonin reduces tactile_allodynia in rats via activation of MT2 and opioid receptors .
18341518	0	melatonin	44,53	MT2	40,43	melatonin	MT2	MESH:D008550	4502	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	C-terminal domains within human MT1 and MT2 melatonin receptors are involved in internalization processes .
18544139	0	melatonin	72,81	MT2	68,71	melatonin	MT2	MESH:D008550	4502	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	The role of proline residues in the structure and function of human MT2 melatonin receptor .
18621029	0	melatonin	87,96	MT2	83,86	melatonin	MT2	MESH:D008550	17750(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Melatonin signaling in mouse cerebellar granule cells with variable native MT1 and MT2 melatonin receptors .
19429170	0	melatonin	48,57	MT2	44,47	melatonin	MT2	MESH:D008550	689415(Tax:10116)	Chemical	Gene	agonist|compound|START_ENTITY agonist|compound|END_ENTITY	Sleep-promoting action of IIK7 , a selective MT2 melatonin receptor agonist in the rat .
19556449	0	melatonin	77,86	MT2	73,76	melatonin	MT2	MESH:D008550	4502	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Molecular cloning and pharmacological characterization of monkey MT1 and MT2 melatonin receptors showing high affinity for the agonist ramelteon .
19728077	0	melatonin	4,13	MT2	0,3	melatonin	MT2	MESH:D008550	4502	Chemical	Gene	immunoreactivity|compound|START_ENTITY immunoreactivity|compound|END_ENTITY	MT2 melatonin receptor immunoreactivity in neurons is very high in the aged hippocampal formation in gerbils .
20524795	0	melatonin	40,49	MT2	36,39	melatonin	MT2	MESH:D008550	4502	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Photoperiodic regulation of MT1 and MT2 melatonin receptor expression in spleen and thymus of a tropical rodent Funambulus pennanti during reproductively active and inactive phases .
20544829	0	melatonin	107,116	MT2	103,106	melatonin	MT2	MESH:D008550	4502	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Melatonin 's protective action against ischemic neuronal_damage is associated with up-regulation of the MT2 melatonin receptor .
20959363	0	melatonin	48,57	MT2	0,3	melatonin	MT2	MESH:D008550	4502	Chemical	Gene	effects|nmod|START_ENTITY mediate|dobj|effects mediate|nsubj|receptors receptors|compound|END_ENTITY	MT2 receptors mediate the inhibitory effects of melatonin on nitric_oxide-induced relaxation of porcine isolated coronary arteries .
22149391	0	melatonin	28,37	MT2	62,65	melatonin	MT2	MESH:D008550	4544	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|MT1 MT1|dep|END_ENTITY	Age dependent expression of melatonin membrane receptor -LRB- MT1 , MT2 -RRB- and its role in regulation of nitrosative stress in tropical rodent Funambulus pennanti .
22489607	0	melatonin	15,24	MT2	134,137	melatonin	MT2	MESH:D008550	17750(Tax:10090)	Chemical	Gene	signal|nsubj|START_ENTITY signal|advcl|acting acting|nmod|receptors receptors|nummod|END_ENTITY	The endogenous melatonin -LRB- MT -RRB- signal facilitates reentrainment of the circadian system to light-induced phase advances by acting upon MT2 receptors .
23131177	0	melatonin	87,96	MT2	97,100	melatonin	MT2	MESH:D008550	4502	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Characterization of substituted phenylpropylamides as highly selective agonists at the melatonin MT2 receptor .
23541165	0	melatonin	41,50	MT2	37,40	melatonin	MT2	MESH:D008550	4502	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Structure-based virtual screening of MT2 melatonin receptor : influence of template choice and structural refinement .
23798576	0	melatonin	105,114	MT2	115,118	melatonin	MT2	MESH:D008550	4544	Chemical	Gene	variants|amod|START_ENTITY variants|compound|END_ENTITY	Minireview : Toward the establishment of a link between melatonin and glucose homeostasis : association of melatonin MT2 receptor variants with type_2_diabetes .
23798576	0	melatonin	55,64	MT2	115,118	melatonin	MT2	MESH:D008550	4544	Chemical	Gene	homeostasis|compound|START_ENTITY link|nmod|homeostasis establishment|nmod|link Minireview|nmod|establishment Minireview|dep|association association|nmod|variants variants|compound|END_ENTITY	Minireview : Toward the establishment of a link between melatonin and glucose homeostasis : association of melatonin MT2 receptor variants with type_2_diabetes .
23971978	0	melatonin	22,31	MT2	32,35	melatonin	MT2	MESH:D008550	4544	Chemical	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	Unveiling the role of melatonin MT2 receptors in sleep , anxiety and other neuropsychiatric_diseases : a novel target in psychopharmacology .
24005634	0	melatonin	16,25	MT2	26,29	melatonin	MT2	MESH:D008550	4544	Chemical	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	-LSB- Involvement of melatonin MT2 receptor mutants in type_2_diabetes development -RSB- .
24031039	0	melatonin	85,94	MT2	100,103	melatonin	MT2	MESH:D008550	4502	Chemical	Gene	MT1|compound|START_ENTITY Synthesis|nmod|MT1 Synthesis|dep|agonist agonist|nummod|END_ENTITY	Synthesis and pharmacological evaluation of a series of the agomelatine analogues as melatonin MT1 / MT2 agonist and 5-HT2C antagonist .
24813704	0	melatonin	35,44	MT2	31,34	melatonin	MT2	MESH:D008550	17750(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Genetic deletion of the MT1 or MT2 melatonin receptors abrogates methamphetamine-induced reward in C3H/HeN mice .
24909617	0	melatonin	37,46	MT2	47,50	melatonin	MT2	MESH:D008550	689415(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Regional upregulation of hippocampal melatonin MT2 receptors by valproic_acid : therapeutic implications for Alzheimer 's _ disease .
25599452	0	melatonin	10,19	MT2	20,23	melatonin	MT2	MESH:D008550	689415(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Selective melatonin MT2 receptor ligands relieve neuropathic_pain through modulation of brainstem descending antinociceptive pathways .
26162699	0	melatonin	44,53	MT2	40,43	melatonin	MT2	MESH:D008550	4502	Chemical	Gene	agonists|compound|START_ENTITY agonists|compound|END_ENTITY	Antinociceptive properties of selective MT2 melatonin receptor partial agonists .
15470001	0	melatonin	7,16	MTNR1A	0,6	melatonin	MTNR1A	MESH:D008550	443022(Tax:9940)	Chemical	Gene	receptors|compound|START_ENTITY receptors|nummod|END_ENTITY	MTNR1A melatonin receptors in the ovine premammillary hypothalamus : day-night variation in the expression of the transcripts .
18243602	0	melatonin	28,37	MTNR1A	21,27	melatonin	MTNR1A	MESH:D008550	102189094	Chemical	Gene	START_ENTITY|nsubj|Relationship Relationship|nmod|END_ENTITY	Relationship between MTNR1A melatonin receptor gene polymorphism and seasonal reproduction in different goat breeds .
25375207	0	melatonin	14,23	MTNR1A	58,64	melatonin	MTNR1A	MESH:D008550	443022(Tax:9940)	Chemical	Gene	treatment|compound|START_ENTITY treatment|appos|melatonin_receptor_1A melatonin_receptor_1A|appos|END_ENTITY	Influences of melatonin treatment , melatonin_receptor_1A -LRB- MTNR1A -RRB- and kisspeptin -LRB- KiSS-1 -RRB- gene polymorphisms on first conception in Sarda ewe lambs .
25606429	0	melatonin	81,90	MTNR1A	106,112	melatonin	MTNR1A	MESH:D008550	443022(Tax:9940)	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Sequence analysis and identification of new variations in the coding sequence of melatonin receptor gene -LRB- MTNR1A -RRB- of Indian Chokla sheep breed .
20959387	0	melatonin	53,62	MTNR1B	73,79	melatonin	MTNR1B	MESH:D008550	4544	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association of rs10830963 and rs10830962 SNPs in the melatonin receptor -LRB- MTNR1B -RRB- gene among Han Chinese women with polycystic_ovary_syndrome .
25939854	0	melatonin	30,39	MTNR1B	40,46	melatonin	MTNR1B	MESH:D008550	4544	Chemical	Gene	expression|compound|START_ENTITY expression|nummod|END_ENTITY	Circadian clock regulation of melatonin MTNR1B receptor expression in human myometrial smooth muscle cells .
26440713	0	melatonin	80,89	MTNR1B	39,45	melatonin	MTNR1B	MESH:D008550	4544	Chemical	Gene	effect|nmod|START_ENTITY worsens|dobj|effect worsens|nsubj|variant variant|nmod|END_ENTITY	Common type_2_diabetes risk variant in MTNR1B worsens the deleterious effect of melatonin on glucose tolerance in humans .
17614836	0	melatonin	65,74	Matrix_metalloproteinase-9	0,26	melatonin	Matrix metalloproteinase-9	MESH:D008550	17395(Tax:10090)	Chemical	Gene	reduced|nmod|START_ENTITY reduced|nsubjpass|activity activity|compound|END_ENTITY	Matrix_metalloproteinase-9 activity and expression is reduced by melatonin during prevention of ethanol-induced gastric_ulcer in mice .
16959416	0	melatonin	38,47	Mel1b	32,37	melatonin	Mel1b	MESH:D008550	244701(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Targeted deletions of Mel1a and Mel1b melatonin receptors affect pCREB levels in lactotroph and pars intermedia cells of mice .
11316328	0	melatonin	77,86	Mel1c	71,76	melatonin	Mel1c	MESH:D008550	9248	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Chimeric Galphaq subunits can distinguish the long form of the Xenopus Mel1c melatonin receptor from the mammalian mt1 and MT2 melatonin receptors .
11948236	0	melatonin	74,83	Mel1c	105,110	melatonin	Mel1c	MESH:D008550	378544(Tax:8355)	Chemical	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	Molecular determinants for the differential coupling of Galpha -LRB- 16 -RRB- to the melatonin MT1 , MT2 and Xenopus Mel1c receptors .
9212055	0	melatonin	24,33	Mel1c	18,23	melatonin	Mel1c	MESH:D008550	9248	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Novel isoforms of Mel1c melatonin receptors modulating intracellular cyclic_guanosine_3 ' ,5 ' - monophosphate levels .
23598442	0	melatonin	22,31	Npas4	0,5	melatonin	Npas4	MESH:D008550	266743	Chemical	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	Npas4 is activated by melatonin , and drives the clock gene Cry1 in the ovine pars tuberalis .
20433640	0	melatonin	10,19	Nrf2	41,45	melatonin	Nrf2	MESH:D008550	83619(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	Effect of melatonin on the expression of Nrf2 and NF-kappaB during cyclophosphamide-induced urinary_bladder_injury in rat .
22331175	0	melatonin	30,39	P50	43,46	melatonin	P50	MESH:D008550	4790	Chemical	Gene	START_ENTITY|nmod|suppression suppression|compound|END_ENTITY	The effect of acute exogenous melatonin on P50 suppression in healthy male volunteers stratified for low and high gating levels .
14644645	0	melatonin	32,41	PACAP	14,19	melatonin	PACAP	MESH:D008550	408251(Tax:9031)	Chemical	Gene	release|compound|START_ENTITY effect|nmod|release effect|nmod|END_ENTITY	The effect of PACAP on rhythmic melatonin release of avian pineals .
16888177	0	melatonin	45,54	PACAP	15,20	melatonin	PACAP	MESH:D008550	408251(Tax:9031)	Chemical	Gene	secretion|compound|START_ENTITY effects|nmod|secretion effects|nmod|END_ENTITY	The effects of PACAP and VIP on the in vitro melatonin secretion from the embryonic chicken pineal gland .
12644299	0	melatonin	70,79	PL-II	87,92	melatonin	PL-II	MESH:D008550	24283(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Circadian expression of Mel1a and PL-II genes in placenta : effects of melatonin on the PL-II gene expression in the rat placenta .
10026105	0	melatonin	99,108	Prolactin	0,9	melatonin	Prolactin	MESH:D008550	5617	Chemical	Gene	treated|nmod|START_ENTITY rams|acl|treated inhibit|nmod|rams fails|xcomp|inhibit fails|nsubj|replacement replacement|compound|END_ENTITY	Prolactin replacement fails to inhibit reactivation of gonadotropin secretion in rams treated with melatonin under long days .
3593120	0	melatonin	74,83	Prolactin	0,9	melatonin	Prolactin	MESH:D008550	5617	Chemical	Gene	administration|nmod|START_ENTITY ewes|nmod|administration ewes|nsubj|response response|compound|END_ENTITY	Prolactin response in Border-Leicester x merino ewes to administration of melatonin , melatonin analogues , a melatonin metabolite and 6-methoxybenzoxazolinone .
12096835	4	melatonin	1464,1473	RANKL	1495,1500	melatonin	RANKL	MESH:D008550	21943(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Because RANKL increases , while osteoprotegerin -LRB- OPG -RRB- serves as a soluble decoy receptor for RANKL to inhibit osteoclast formation and activity , the effect of melatonin on the expression of RANKL and OPG in mouse MC3T3-E1 osteoblastic cells was investigated .
22507555	0	melatonin	48,57	SIRT1	170,175	melatonin	SIRT1	MESH:D008550	100349271(Tax:9986)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|osteoarthritis osteoarthritis|nmod|pathway pathway|compound|END_ENTITY	Cytoprotective and anti-inflammatory effects of melatonin in hydrogen_peroxide-stimulated CHON-001 human chondrocyte cell line and rabbit model of osteoarthritis via the SIRT1 pathway .
23726949	0	melatonin	20,29	SIRT1	0,5	melatonin	SIRT1	MESH:D008550	23411	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nummod|END_ENTITY	SIRT1 inhibition by melatonin exerts antitumor activity in human osteosarcoma cells .
6113952	0	melatonin	64,73	Somatostatin	0,12	melatonin	Somatostatin	MESH:D008550	24797(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY release|dep|effects release|compound|END_ENTITY	Somatostatin release from rat hypothalamus in vitro : effects of melatonin and serotonin .
25859403	0	melatonin	23,32	TNF-a	86,91	melatonin	TNF-a	MESH:D008550	24835(Tax:10116)	Chemical	Gene	administration|nmod|START_ENTITY modulates|nsubj|administration modulates|dobj|expression expression|nmod|gene gene|appos|END_ENTITY	Oral administration of melatonin modulates the expression of tumor_necrosis_factor-a -LRB- TNF-a -RRB- gene in irradiated rat cervical spinal cord .
17014691	0	melatonin	27,36	TNF-alpha	10,19	melatonin	TNF-alpha	MESH:D008550	24835(Tax:10116)	Chemical	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	Effect of TNF-alpha on the melatonin synthetic pathway in the rat pineal gland : basis for a ` feedback ' of the immune response on circadian timing .
11684043	0	melatonin	20,29	arg-vasopressin	63,78	melatonin	arg-vasopressin	MESH:D008550	24221(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY rhythm|nmod|release rhythm|dep|inhibits inhibits|amod|END_ENTITY	Circadian rhythm of melatonin release in pineal gland culture : arg-vasopressin inhibits melatonin release .
11684043	0	melatonin	88,97	arg-vasopressin	63,78	melatonin	arg-vasopressin	MESH:D008550	24221(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY inhibits|dep|release inhibits|amod|END_ENTITY	Circadian rhythm of melatonin release in pineal gland culture : arg-vasopressin inhibits melatonin release .
20939479	0	melatonin	12,21	bone_morphogenetic_protein_2	39,67	melatonin	bone morphogenetic protein 2	MESH:D008550	29373(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of melatonin on expression of bone_morphogenetic_protein_2 and interleukin_1beta in articular cartilage of rat with osteoarthritis -RSB- .
20459459	0	melatonin	74,83	butyrylcholinesterase	24,45	melatonin	butyrylcholinesterase	MESH:D008550	590	Chemical	Gene	derivatives|compound|START_ENTITY inhibition|nmod|derivatives inhibition|nmod|END_ENTITY	Selective inhibition of butyrylcholinesterase by singlet oxygen-generated melatonin derivatives .
21709008	0	melatonin	10,19	cyclooxygenase-2	23,39	melatonin	cyclooxygenase-2	MESH:D008550	19225(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effect of melatonin on cyclooxygenase-2 expression and nuclear factor-kappa B activation in RAW264 .7 macrophage-like cells stimulated with fimbriae of Porphyromonas_gingivalis .
3783421	0	melatonin	11,20	dopamine-beta-hydroxylase	40,65	melatonin	dopamine-beta-hydroxylase	MESH:D008550	101829122	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effects of melatonin on adrenomedullary dopamine-beta-hydroxylase activity in golden_hamsters : evidence for pineal and dose dependencies .
21678055	0	melatonin	96,105	endocan	51,58	melatonin	endocan	MESH:D008550	11082	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|expression expression|compound|END_ENTITY	Induction of cell differentiation and promotion of endocan gene expression in stomach_cancer by melatonin .
19671631	0	melatonin	10,19	endothelial_NOS	51,66	melatonin	endothelial NOS	MESH:D008550	24600(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of melatonin and vitamin_C on expression of endothelial_NOS in heart of chronic alcoholic rats .
18516076	0	melatonin	35,44	eosinophil_peroxidase	60,81	melatonin	eosinophil peroxidase	MESH:D008550	8288	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Analysis of the mechanism by which melatonin inhibits human eosinophil_peroxidase .
7708056	0	melatonin	51,60	estrogen_receptor	14,31	melatonin	estrogen receptor	MESH:D008550	2099	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Modulation of estrogen_receptor mRNA expression by melatonin in MCF-7 human breast_cancer cells .
8138120	0	melatonin	92,101	estrogen_receptor	13,30	melatonin	estrogen receptor	MESH:D008550	2099	Chemical	Gene	production|compound|START_ENTITY Detection|dep|production Detection|nmod|mRNA mRNA|compound|END_ENTITY	Detection of estrogen_receptor mRNA in trout pineal and retina : estradiol-17 beta modulates melatonin production by cultured pineal photoreceptor cells .
15750583	0	melatonin	188,197	estrogen_receptor_alpha	110,133	melatonin	estrogen receptor alpha	MESH:D008550	2099	Chemical	Gene	cells|nmod|START_ENTITY inhibition|dep|cells inhibition|nmod|poliferation poliferation|nmod|END_ENTITY	Transient inhibition of synergistically insulin-like_growth_factor-1 - and bisphenol_A-induced poliferation of estrogen_receptor_alpha -LRB- ERalpha -RRB- - positive human breast_cancer MCF-7 cells by melatonin .
15813899	0	melatonin	137,146	estrogen_receptor_alpha	27,50	melatonin	estrogen receptor alpha	MESH:D008550	2099	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Differential regulation of estrogen_receptor_alpha , glucocorticoid_receptor and retinoic_acid_receptor_alpha transcriptional activity by melatonin is mediated via different G proteins .
11377981	0	melatonin	49,58	glucocorticoid_receptor	89,112	melatonin	glucocorticoid receptor	MESH:D008550	2908	Chemical	Gene	effects|nmod|START_ENTITY involve|nsubj|effects involve|dobj|pathways pathways|compound|END_ENTITY	The neuroprotective and antiapoptotic effects of melatonin in cerebellar neurons involve glucocorticoid_receptor and p130 signal pathways .
11428904	0	melatonin	11,20	glucose-6-phosphate_dehydrogenase	45,78	melatonin	glucose-6-phosphate dehydrogenase	MESH:D008550	2539	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activities activities|nmod|END_ENTITY	Effects of melatonin on enzyme activities of glucose-6-phosphate_dehydrogenase from human erythrocytes in vitro and from rat erythrocytes in vivo .
18615393	0	melatonin	15,24	glutathione_peroxidase	28,50	melatonin	glutathione peroxidase	MESH:D008550	24404(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activity activity|amod|END_ENTITY	The effects of melatonin on glutathione_peroxidase activity in serum and erythrocytes after adriamycin in normal and pinealectomised rats .
16626690	0	melatonin	10,19	glutathione_reductase	44,65	melatonin	glutathione reductase	MESH:D008550	2936	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of melatonin on enzyme activities of glutathione_reductase from human erythrocytes in vitro and from rat erythrocytes in vivo .
8910811	0	melatonin	10,19	gonadotropin-releasing_hormone	38,68	melatonin	gonadotropin-releasing hormone	MESH:D008550	25194(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|release release|nmod|END_ENTITY	Effect of melatonin on the release of gonadotropin-releasing_hormone and cyclic_AMP from the rat hypothalamus : an in vitro study .
7532183	0	melatonin	104,113	granulocyte-macrophage_colony_stimulating_factor	10,58	melatonin	granulocyte-macrophage colony stimulating factor	MESH:D008550	116630(Tax:10116)	Chemical	Gene	secretion|compound|START_ENTITY Effect|nmod|secretion Effect|nmod|END_ENTITY	Effect of granulocyte-macrophage_colony_stimulating_factor and granulocyte_colony_stimulating_factor on melatonin secretion in rats in vivo and in vitro studies .
10189054	0	melatonin	36,45	growth_hormone	49,63	melatonin	growth hormone	MESH:D008550	2688	Chemical	Gene	effects|nmod|START_ENTITY abolishes|dobj|effects abolishes|nmod|secretion secretion|amod|END_ENTITY	Alcoholism abolishes the effects of melatonin on growth_hormone secretion in humans .
11315319	0	melatonin	140,149	growth_hormone	30,44	melatonin	growth hormone	MESH:D008550	81668(Tax:10116)	Chemical	Gene	primed|nmod|START_ENTITY primed|nsubj|END_ENTITY	In vitro pituitary prolactin , growth_hormone and follicle stimulating hormone secretion during sexual maturation of female rats primed with melatonin .
1341480	0	melatonin	39,48	growth_hormone	66,80	melatonin	growth hormone	MESH:D008550	2688	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|secreting secreting|compound|END_ENTITY	A clinical study of the pineal hormone melatonin in patients with growth_hormone or prolactin secreting pituitary_tumours .
17286742	0	melatonin	10,19	growth_hormone	52,66	melatonin	growth hormone	MESH:D008550	2688	Chemical	Gene	concentrations|compound|START_ENTITY concentrations|nmod|children children|nmod|deficiency deficiency|amod|END_ENTITY	Increased melatonin concentrations in children with growth_hormone deficiency .
447817	0	melatonin	10,19	growth_hormone	64,78	melatonin	growth hormone	MESH:D008550	2688	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|amod|END_ENTITY	Effect of melatonin on L-tryptophan - and apomorphine-stimulated growth_hormone secretion in man .
4600047	0	melatonin	49,58	growth_hormone	21,35	melatonin	growth hormone	MESH:D008550	2688	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Suppression Suppression|nmod|END_ENTITY	Suppression of human growth_hormone secretion by melatonin and cyproheptadine .
7288433	0	melatonin	21,30	growth_hormone	66,80	melatonin	growth hormone	MESH:D008550	2688	Chemical	Gene	effect|nmod|START_ENTITY Lack|nmod|effect stimulated|nsubj|Lack stimulated|dobj|secretion secretion|amod|END_ENTITY	Lack of an effect of melatonin on the basal and L-dopa stimulated growth_hormone secretion in men .
9062871	0	melatonin	234,243	growth_hormone	45,59	melatonin	growth hormone	MESH:D008550	81668(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|rhythms rhythms|nmod|prolactin prolactin|appos|levels levels|amod|END_ENTITY	Twenty-four hour rhythms of serum prolactin , growth_hormone and luteinizing hormone levels , and of medial basal hypothalamic corticotropin-releasing_hormone levels and dopamine and serotonin metabolism in rats neonatally administered melatonin .
9667227	0	melatonin	64,73	growth_hormone	37,51	melatonin	growth hormone	MESH:D008550	2688	Chemical	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Different effects of naloxone on the growth_hormone response to melatonin and pyridostigmine in normal men .
12604667	0	melatonin	120,129	hMT2	115,119	melatonin	hMT2	MESH:D008550	4502	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Short-term exposure to melatonin differentially affects the functional sensitivity and trafficking of the hMT1 and hMT2 melatonin receptors .
12628486	0	melatonin	84,93	hMT2	79,83	melatonin	hMT2	MESH:D008550	4544	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Melatonin differentially modulates the expression and function of the hMT1 and hMT2 melatonin receptors upon prolonged withdrawal .
17403780	0	melatonin	62,71	hnRNP_Q	41,48	melatonin	hnRNP Q	MESH:D008550	10492	Chemical	Gene	production|compound|START_ENTITY control|nmod|production control|nmod|END_ENTITY	Rhythmic control of AANAT translation by hnRNP_Q in circadian melatonin production .
12800246	0	melatonin	11,20	iNOS	42,46	melatonin	iNOS	MESH:D008550	24599(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of melatonin on the expression of iNOS and COX-2 in rat models of colitis .
16098092	0	melatonin	74,83	iNOS	93,97	melatonin	iNOS	MESH:D008550	18126(Tax:10090)	Chemical	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Tissue-plasminogen activator-induced ischemic brain_injury is reversed by melatonin : role of iNOS and Akt .
17049787	0	melatonin	100,109	iNOS	41,45	melatonin	iNOS	MESH:D008550	24599(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY effects|nmod|treatment END_ENTITY|dep|effects	Age-dependent lipopolysaccharide-induced iNOS expression and multiorgan_failure in rats : effects of melatonin treatment .
19814638	0	melatonin	30,39	iNOS	110,114	melatonin	iNOS	MESH:D008550	24599(Tax:10116)	Chemical	Gene	efficacy|nmod|START_ENTITY Comparison|nmod|efficacy Comparison|dep|injury injury|dep|role role|nmod|END_ENTITY	Comparison of the efficacy of melatonin and 1400W on renal_ischemia / reperfusion injury : a role for inhibiting iNOS .
24117944	0	melatonin	26,35	iNOS	104,108	melatonin	iNOS	MESH:D008550	18126(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|inhibition inhibition|nmod|END_ENTITY	The beneficial effects of melatonin against heart mitochondrial impairment during sepsis : inhibition of iNOS and preservation of nNOS .
8171739	0	melatonin	71,80	interleukin-2	35,48	melatonin	interleukin-2	MESH:D008550	3558	Chemical	Gene	therapy|nmod|START_ENTITY therapy|nmod|END_ENTITY	Subcutaneous therapy with low-dose interleukin-2 plus the neurohormone melatonin in metastatic gastric_cancer patients with low performance status .
11098835	0	melatonin	10,19	leptin	40,46	melatonin	leptin	MESH:D008550	3952	Chemical	Gene	elevates|nsubj|START_ENTITY elevates|dobj|END_ENTITY	Exogenous melatonin elevates the plasma leptin and thyroxine concentrations of the mink -LRB- Mustela vison -RRB- .
11779031	0	melatonin	38,47	leptin	57,63	melatonin	leptin	MESH:D008550	25608(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Effects of pinealectomy and exogenous melatonin on serum leptin levels in male rat .
16842538	0	melatonin	38,47	leptin	129,135	melatonin	leptin	MESH:D008550	25608(Tax:10116)	Chemical	Gene	exposure|nmod|START_ENTITY enhances|nsubj|exposure enhances|nmod|expression expression|compound|END_ENTITY	Intermittent and rhythmic exposure to melatonin in primary cultured adipocytes enhances the insulin and dexamethasone effects on leptin expression .
16860966	0	melatonin	41,50	leptin	23,29	melatonin	leptin	MESH:D008550	3952	Chemical	Gene	secretion|compound|START_ENTITY suppresses|dobj|secretion suppresses|nsubj|END_ENTITY	In vitro evidence that leptin suppresses melatonin secretion during long days and stimulates its secretion during short_days in seasonal breeding ewes .
18451065	0	melatonin	60,69	leptin	28,34	melatonin	leptin	MESH:D008550	443534(Tax:9940)	Chemical	Gene	secretion|nmod|START_ENTITY effects|nmod|secretion effects|nmod|infusion infusion|compound|END_ENTITY	Seasonal effects of central leptin infusion on secretion of melatonin and prolactin and on SOCS-3 gene expression in ewes .
20015831	0	melatonin	11,20	leptin	46,52	melatonin	leptin	MESH:D008550	16846(Tax:10090)	Chemical	Gene	administration|compound|START_ENTITY administration|nmod|concentration concentration|compound|END_ENTITY	Effects of melatonin administration on plasma leptin concentration and adipose tissue leptin secretion in mice .
21185681	0	melatonin	45,54	leptin	35,41	melatonin	leptin	MESH:D008550	3952	Chemical	Gene	secretion|compound|START_ENTITY END_ENTITY|nmod|secretion	Effects of orexigenic peptides and leptin on melatonin secretion during different photoperiods in seasonal breeding ewes : an in vitro study .
25539049	0	melatonin	64,73	leptin	36,42	melatonin	leptin	MESH:D008550	25608(Tax:10116)	Chemical	Gene	tissues|nmod|START_ENTITY END_ENTITY|nmod|tissues	Immunohistochemical distribution of leptin in kidney tissues of melatonin treated diabetic rats .
26103557	0	melatonin	41,50	leptin	57,63	melatonin	leptin	MESH:D008550	3952	Chemical	Gene	chronobiotic|appos|START_ENTITY Inter-relationships|nmod|chronobiotic Inter-relationships|nmod|END_ENTITY	Inter-relationships of the chronobiotic , melatonin , with leptin and adiponectin : implications for obesity .
6122168	0	melatonin	15,24	luteinizing_hormone-releasing_hormone	50,87	melatonin	luteinizing hormone-releasing hormone	MESH:D008550	25194(Tax:10116)	Chemical	Gene	pituitary|compound|START_ENTITY Selectivity|nmod|pituitary inhibition|nsubj|Selectivity inhibition|nmod|END_ENTITY	Selectivity of melatonin pituitary inhibition for luteinizing_hormone-releasing_hormone .
7045869	0	melatonin	15,24	luteinizing_hormone-releasing_hormone	76,113	melatonin	luteinizing hormone-releasing hormone	MESH:D008550	25194(Tax:10116)	Chemical	Gene	stimulate|nsubj|START_ENTITY stimulate|dobj|release release|nmod|END_ENTITY	Acetylcholine , melatonin , and potassium depolarization stimulate release of luteinizing_hormone-releasing_hormone from rat hypothalamus in vitro .
7626711	0	melatonin	72,81	luteinizing_hormone-releasing_hormone	14,51	melatonin	luteinizing hormone-releasing hormone	MESH:D008550	2796	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- secretion by melatonin in the ewe .
7626716	0	melatonin	72,81	luteinizing_hormone-releasing_hormone	14,51	melatonin	luteinizing hormone-releasing hormone	MESH:D008550	443529(Tax:9940)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- secretion by melatonin in the ewe .
19097803	0	melatonin	21,30	lysozyme	50,58	melatonin	lysozyme	MESH:D008550	4069	Chemical	Gene	effect|nmod|START_ENTITY effect|acl|END_ENTITY	Protective effect of melatonin on photo-damage to lysozyme .
11589761	0	melatonin	8,17	mREN2	36,41	melatonin	mREN2	MESH:D008550	19702(Tax:10090)	Chemical	Gene	production|compound|START_ENTITY production|appos|END_ENTITY	Altered melatonin production in TGR -LRB- mREN2 -RRB- 27 rats : on the regulation by adrenergic agonists , antagonists and angiotensin_II in cultured pinealocytes .
17126384	0	melatonin	22,31	matrix_metalloproteinase-9	48,74	melatonin	matrix metalloproteinase-9	MESH:D008550	4318	Chemical	Gene	levels|compound|START_ENTITY Relation|nmod|levels Relation|acl|serum serum|dobj|concentrations concentrations|amod|END_ENTITY	Relation of nocturnal melatonin levels to serum matrix_metalloproteinase-9 concentrations in patients with myocardial_infarction .
24269215	0	melatonin	21,30	matrix_metalloproteinase-9	121,147	melatonin	matrix metalloproteinase-9	MESH:D008550	17395(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Protective effect of melatonin against transient global cerebral_ischemia-induced neuronal_cell_damage via inhibition of matrix_metalloproteinase-9 .
24768045	4	melatonin	743,752	melatonin	810,819	melatonin	Cyclin D1	MESH:D008550	524530(Tax:9913)	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nmod|END_ENTITY	We found that bovine SCs express MT1 and MT2 receptors , which were regulated by melatonin in time - and dose-dependent manners after treatment with melatonin .
10465462	0	melatonin	18,27	mt1	14,17	melatonin	mt1	MESH:D008550	24567(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Expression of mt1 melatonin receptor in rat retina : evidence for multiple cell targets for melatonin .
10465462	0	melatonin	91,100	mt1	14,17	melatonin	mt1	MESH:D008550	24567(Tax:10116)	Chemical	Gene	targets|nmod|START_ENTITY evidence|nmod|targets Expression|dep|evidence Expression|nmod|receptor receptor|amod|END_ENTITY	Expression of mt1 melatonin receptor in rat retina : evidence for multiple cell targets for melatonin .
10718916	0	melatonin	25,34	mt1	21,24	melatonin	mt1	MESH:D008550	644314	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Photic regulation of mt1 melatonin receptors in the Siberian hamster pars tuberalis and suprachiasmatic nuclei : involvement of the circadian clock and intergeniculate leaflet .
10739306	0	melatonin	24,33	mt1	20,23	melatonin	mt1	MESH:D008550	17748(Tax:10090)	Chemical	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Circadian rhythm of mt1 melatonin receptor expression in the suprachiasmatic nucleus of the C3H/HeN mouse .
10842331	0	melatonin	117,126	mt1	113,116	melatonin	mt1	MESH:D008550	644314	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Melatonin induction of filamentous structures in non-neuronal cells that is dependent on expression of the human mt1 melatonin receptor .
10884567	0	melatonin	30,39	mt1	82,85	melatonin	mt1	MESH:D008550	17748(Tax:10090)	Chemical	Gene	agonists|amod|START_ENTITY properties|nmod|agonists properties|dep|involvement involvement|nmod|receptors receptors|amod|END_ENTITY	Anxiolytic-like properties of melatonin receptor agonists in mice : involvement of mt1 and/or MT2 receptors in the regulation of emotional responsiveness .
11316328	0	melatonin	77,86	mt1	115,118	melatonin	mt1	MESH:D008550	644314	Chemical	Gene	receptor|compound|START_ENTITY receptor|nmod|END_ENTITY	Chimeric Galphaq subunits can distinguish the long form of the Xenopus Mel1c melatonin receptor from the mammalian mt1 and MT2 melatonin receptors .
11888668	0	melatonin	23,32	mt1	19,22	melatonin	mt1	MESH:D008550	644314	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Involvement of the mt1 melatonin receptor in human breast_cancer .
12486087	0	melatonin	8,17	mt1	4,7	melatonin	mt1	MESH:D008550	644314	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	The mt1 melatonin receptor and RORbeta receptor are co-localized in specific TSH-immunoreactive cells in the pars tuberalis of the rat pituitary .
12519889	0	melatonin	121,130	mt1	0,3	melatonin	mt1	MESH:D008550	644314	Chemical	Gene	production|nmod|START_ENTITY inhibition|nmod|production receptor|dep|inhibition receptor|amod|END_ENTITY	mt1 Melatonin receptor in the primate adrenal gland : inhibition of adrenocorticotropin-stimulated cortisol production by melatonin .
15164945	0	melatonin	10,19	mt1	80,83	melatonin	mt1	MESH:D008550	17748(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY mediated|nsubjpass|Effect mediated|nmod|receptors receptors|amod|END_ENTITY	Effect of melatonin on the oxidative stress in N1E-115 cells is not mediated by mt1 receptors .
9645677	0	melatonin	187,196	mt1	183,186	melatonin	mt1	MESH:D008550	644314	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Physiological exposure to melatonin supersensitizes the cyclic_adenosine_3 ' ,5 ' - monophosphate-dependent signal transduction cascade in Chinese_hamster_ovary cells expressing the human mt1 melatonin receptor .
9645677	0	melatonin	26,35	mt1	183,186	melatonin	mt1	MESH:D008550	644314	Chemical	Gene	exposure|nmod|START_ENTITY supersensitizes|nsubj|exposure supersensitizes|xcomp|expressing expressing|dobj|receptor receptor|amod|END_ENTITY	Physiological exposure to melatonin supersensitizes the cyclic_adenosine_3 ' ,5 ' - monophosphate-dependent signal transduction cascade in Chinese_hamster_ovary cells expressing the human mt1 melatonin receptor .
9802327	0	melatonin	36,45	mt1	46,49	melatonin	mt1	MESH:D008550	644314	Chemical	Gene	stimulation|amod|START_ENTITY stimulation|amod|END_ENTITY	Pharmacological characterisation of melatonin mt1 receptor-mediated stimulation of -LSB- 35S -RSB- - GTPgammaS binding .
11401469	0	melatonin	25,34	myeloperoxidase	46,61	melatonin	myeloperoxidase	MESH:D008550	4353	Chemical	Gene	Mechanism|nmod|START_ENTITY Mechanism|nmod|END_ENTITY	Mechanism of reaction of melatonin with human myeloperoxidase .
16148002	0	melatonin	34,43	myeloperoxidase	47,62	melatonin	myeloperoxidase	MESH:D008550	4353	Chemical	Gene	oxidation|nmod|START_ENTITY oxidation|nmod|END_ENTITY	Superoxide-dependent oxidation of melatonin by myeloperoxidase .
22271455	0	melatonin	10,19	nNOS	29,33	melatonin	nNOS	MESH:D008550	4842	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Nanomolar melatonin enhances nNOS expression and controls HaCaT-cells bioenergetics .
24117944	0	melatonin	26,35	nNOS	129,133	melatonin	nNOS	MESH:D008550	18125(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|inhibition inhibition|nmod|END_ENTITY	The beneficial effects of melatonin against heart mitochondrial impairment during sepsis : inhibition of iNOS and preservation of nNOS .
15616152	0	melatonin	14,23	p450	45,49	melatonin	p450	MESH:D008550	1555	Chemical	Gene	Metabolism|nmod|START_ENTITY Metabolism|nmod|END_ENTITY	Metabolism of melatonin by human cytochromes p450 .
11324439	0	melatonin	10,19	pro-opiomelanocortin	23,43	melatonin	pro-opiomelanocortin	MESH:D008550	24664(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of melatonin on pro-opiomelanocortin mRNA expression in arcuate nucleus of rat hypothalamus .
12562504	0	melatonin	81,90	pro-opiomelanocortin	28,48	melatonin	pro-opiomelanocortin	MESH:D008550	24664(Tax:10116)	Chemical	Gene	supplementation|compound|START_ENTITY gene|nmod|supplementation gene|nsubj|Suppression Suppression|nmod|END_ENTITY	Suppression of hypothalamic pro-opiomelanocortin -LRB- POMC -RRB- gene expression by daily melatonin supplementation in aging rats .
10766971	0	melatonin	20,29	prolactin	65,74	melatonin	prolactin	MESH:D008550	5617	Chemical	Gene	influence|nmod|START_ENTITY influence|nmod|thyroid thyroid|nmod|END_ENTITY	Direct influence of melatonin on the thyroid and comparison with prolactin .
10831157	0	melatonin	37,46	prolactin	116,125	melatonin	prolactin	MESH:D008550	24683(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY neuron|nsubj|effect neuron|nmod|secretion secretion|compound|END_ENTITY	Stimulatory and entraining effect of melatonin on tuberoinfundibular dopaminergic neuron activity and inhibition on prolactin secretion .
11168905	0	melatonin	66,75	prolactin	25,34	melatonin	prolactin	MESH:D008550	5617	Chemical	Gene	treatment|compound|START_ENTITY Lack|nmod|treatment Lack|nmod|END_ENTITY	Lack of changes in serum prolactin , FSH , TSH , and estradiol after melatonin treatment in doses that improve sleep and reduce benzodiazepine consumption in sleep-disturbed , middle-aged , and elderly patients .
12589398	0	melatonin	23,32	prolactin	116,125	melatonin	prolactin	MESH:D008550	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|development development|nmod|prolactinoma prolactinoma|nmod|relation relation|nmod|END_ENTITY	-LSB- Inhibitory effects of melatonin on the development of 17-beta-estradiol induced prolactinoma in relation to plasma prolactin and peroxidative lipid contents -RSB- .
15063923	0	melatonin	27,36	prolactin	98,107	melatonin	prolactin	MESH:D008550	5617	Chemical	Gene	implants|compound|START_ENTITY Effect|nmod|implants photoperiod|nsubj|Effect photoperiod|nmod|secretion secretion|amod|END_ENTITY	Effect of constant-release melatonin implants and prolonged exposure to a long day photoperiod on prolactin secretion and hair growth in mouflon -LRB- Ovis gmelini musimon -RRB- .
2337624	0	melatonin	11,20	prolactin	88,97	melatonin	prolactin	MESH:D008550	101843376	Chemical	Gene	injections|compound|START_ENTITY Effects|nmod|injections pituitaries|nsubj|Effects pituitaries|xcomp|secrete secrete|dobj|hormone hormone|compound|END_ENTITY	Effects of melatonin injections on the ability of golden_hamster pituitaries to secrete prolactin and luteinizing hormone .
2352119	0	melatonin	13,22	prolactin	61,70	melatonin	prolactin	MESH:D008550	5617	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|component component|nmod|secretion secretion|compound|END_ENTITY	Influence of melatonin on the sleep-independent component of prolactin secretion .
23590508	0	melatonin	11,20	prolactin	43,52	melatonin	prolactin	MESH:D008550	100861193	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of melatonin on salsolinol-induced prolactin secretion in goats .
2709304	0	melatonin	66,75	prolactin	7,16	melatonin	prolactin	MESH:D008550	5617	Chemical	Gene	treatment|compound|START_ENTITY receiving|dobj|treatment ewes|acl|receiving END_ENTITY|nmod|ewes	Plasma prolactin concentrations in pinealectomized ewes receiving melatonin treatment and in pineal intact ewes maintained under a non-24-hour photoperiod .
2737154	0	melatonin	45,54	prolactin	6,15	melatonin	prolactin	MESH:D008550	443317(Tax:9940)	Chemical	Gene	implant|compound|START_ENTITY respond|nmod|implant respond|nsubj|levels levels|compound|END_ENTITY	Fetal prolactin levels respond to a maternal melatonin implant .
2810020	0	melatonin	30,39	prolactin	43,52	melatonin	prolactin	MESH:D008550	101843376	Chemical	Gene	START_ENTITY|nmod|cell cell|compound|END_ENTITY	Sexually dimorphic effects of melatonin on prolactin cell function in male and female syrian_hamsters .
3199061	0	melatonin	70,79	prolactin	22,31	melatonin	prolactin	MESH:D008550	5617	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nmod|END_ENTITY	In-vitro secretion of prolactin and growth_hormone in the presence of melatonin by pituitary gland from mink kept under long or short days .
3950531	0	melatonin	19,28	prolactin	50,59	melatonin	prolactin	MESH:D008550	5617	Chemical	Gene	treatments|compound|START_ENTITY Effects|nmod|treatments Effects|nmod|concentrations concentrations|compound|END_ENTITY	Effects of various melatonin treatments on plasma prolactin concentrations in the ewe .
3958896	0	melatonin	17,26	prolactin	39,48	melatonin	prolactin	MESH:D008550	100861193	Chemical	Gene	infusion|compound|START_ENTITY timed|dobj|infusion timed|nmod|secretion secretion|compound|END_ENTITY	Effects of timed melatonin infusion on prolactin secretion in pineal denervated goat .
4067924	0	melatonin	33,42	prolactin	44,53	melatonin	prolactin	MESH:D008550	5617	Chemical	Gene	pinealectomy|nmod|START_ENTITY Effect|nmod|pinealectomy Effect|appos|concentrations concentrations|compound|END_ENTITY	Effect of pinealectomy on plasma melatonin , prolactin and progesterone concentrations during seasonal reproductive quiescence in the tammar , Macropus eugenii .
490086	0	melatonin	11,20	prolactin	39,48	melatonin	prolactin	MESH:D008550	24683(Tax:10116)	Chemical	Gene	START_ENTITY|acl|increase increase|dobj|levels levels|compound|END_ENTITY	Failure of melatonin to increase serum prolactin levels in ovariectomized rats subjected to superior cervical ganglionectomy or pinelaectomy .
561330	0	melatonin	41,50	prolactin	83,92	melatonin	prolactin	MESH:D008550	24683(Tax:10116)	Chemical	Gene	circulating|dobj|START_ENTITY circulating|nmod|levels levels|compound|END_ENTITY	Effects of neutralization of circulating melatonin and N-acetylserotonin on plasma prolactin levels .
669573	0	melatonin	11,20	prolactin	89,98	melatonin	prolactin	MESH:D008550	24683(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|compound|END_ENTITY	Effects of melatonin and natural and synthetic analogues of arginine_vasotocin on plasma prolactin levels in adult male rats .
6799603	0	melatonin	69,78	prolactin	80,89	melatonin	prolactin	MESH:D008550	5617	Chemical	Gene	levels|nmod|START_ENTITY rhythms|nmod|levels rhythms|acl|END_ENTITY	Age - and mental health-related circadian rhythms of plasma levels of melatonin , prolactin , luteinizing hormone and follicle-stimulating hormone in man .
7861379	0	melatonin	28,37	prolactin	89,98	melatonin	prolactin	MESH:D008550	5617	Chemical	Gene	immunization|nmod|START_ENTITY immunization|nmod|secretion secretion|amod|END_ENTITY	Active immunization against melatonin in Ile-de-France ewes and photoperiodic control of prolactin secretion and ovulatory activity .
7920591	0	melatonin	139,148	prolactin	53,62	melatonin	prolactin	MESH:D008550	488241(Tax:9615)	Chemical	Gene	signal|compound|START_ENTITY translation|nmod|signal evidence|nmod|translation cycles|dep|evidence cycles|nmod|secretion secretion|nmod|END_ENTITY	Photoperiodically-induced cycles in the secretion of prolactin in hypothalamo-pituitary disconnected rams : evidence for translation of the melatonin signal in the pituitary gland .
8013942	0	melatonin	38,47	prolactin	15,24	melatonin	prolactin	MESH:D008550	5617	Chemical	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Stimulation of prolactin secretion by melatonin is not mediated by opioids .
8263466	0	melatonin	10,19	prolactin	46,55	melatonin	prolactin	MESH:D008550	5617	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|nmod|END_ENTITY	Effect of melatonin on pituitary secretion of prolactin in vitro during delayed implantation and the periimplantation period in the spotted skunk .
8648563	0	melatonin	23,32	prolactin	44,53	melatonin	prolactin	MESH:D008550	5617	Chemical	Gene	START_ENTITY|appos|cortisol cortisol|appos|END_ENTITY	Overnight human plasma melatonin , cortisol , prolactin , TSH , under conditions of normal sleep , _ sleep_deprivation , and sleep recovery .
9062871	0	melatonin	234,243	prolactin	34,43	melatonin	prolactin	MESH:D008550	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|rhythms rhythms|nmod|END_ENTITY	Twenty-four hour rhythms of serum prolactin , growth_hormone and luteinizing hormone levels , and of medial basal hypothalamic corticotropin-releasing_hormone levels and dopamine and serotonin metabolism in rats neonatally administered melatonin .
9241064	0	melatonin	27,36	prolactin	95,104	melatonin	prolactin	MESH:D008550	5617	Chemical	Gene	signal|compound|START_ENTITY Refractoriness|nmod|signal develops|nsubj|Refractoriness develops|nmod|gland gland|nmod|control control|nmod|secretion secretion|compound|END_ENTITY	Refractoriness to a static melatonin signal develops in the pituitary gland for the control of prolactin secretion in the ram .
17910598	0	melatonin	89,98	quinone_reductase-2	51,70	melatonin	quinone reductase-2	MESH:D008550	4835	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|appos|receptor	Melatonin as a naturally occurring co-substrate of quinone_reductase-2 , the putative MT3 melatonin membrane receptor : hypothesis and significance .
20204307	0	melatonin	22,31	sulfatase	35,44	melatonin	sulfatase	MESH:D008550	347527	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activity activity|amod|END_ENTITY	Inhibitory effects of melatonin on sulfatase and 17beta-hydroxysteroid_dehydrogenase activity and expression in glioma cells .
26202881	0	melatonin	68,77	thrombin	43,51	melatonin	thrombin	MESH:D008550	2147	Chemical	Gene	generation|nmod|START_ENTITY generation|compound|END_ENTITY	Reduced peak , but no diurnal variation , in thrombin generation upon melatonin supplementation in tetraplegia .
26202881	0	melatonin	68,77	thrombin	43,51	melatonin	thrombin	MESH:D008550	2147	Chemical	Gene	generation|nmod|START_ENTITY generation|compound|END_ENTITY	Reduced peak , but no diurnal variation , in thrombin generation upon melatonin supplementation in tetraplegia .
22768337	0	melatonin	54,63	tumor_necrosis_factor	77,98	melatonin	tumor necrosis factor	MESH:D008550	7124	Chemical	Gene	synthesis|compound|START_ENTITY synthesis|nmod|END_ENTITY	Glia-pinealocyte network : the paracrine modulation of melatonin synthesis by tumor_necrosis_factor -LRB- TNF -RRB- .
17482356	0	melatonin	49,58	tyrosine_hydroxylase	14,34	melatonin	tyrosine hydroxylase	MESH:D008550	7054	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|expression expression|amod|END_ENTITY	Modulation of tyrosine_hydroxylase expression by melatonin in human SH-SY5Y neuroblastoma cells .
19779980	0	melatonin	11,20	vascular_endothelial_growth_factor	81,115	melatonin	vascular endothelial growth factor	MESH:D008550	83785(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of melatonin and phospholipid on adhesion formation and correlation with vascular_endothelial_growth_factor expression in rats .
23013414	0	melatonin	52,61	vascular_endothelial_growth_factor	14,48	melatonin	vascular endothelial growth factor	MESH:D008550	7422	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of vascular_endothelial_growth_factor by melatonin in human breast_cancer cells .
2475235	0	melittin	31,39	Phospholipase_A2	0,16	melittin	Phospholipase A2	MESH:D008555	151056	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Phospholipase_A2 activation by melittin causes amylase release from exocrine pancreas .
14499668	0	melittin	29,37	secretory_phospholipase_A2	95,121	melittin	secretory phospholipase A2	MESH:D008555	8399	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Bimodal regulatory effect of melittin and phospholipase_A2-activating_protein on human type II secretory_phospholipase_A2 .
10810234	0	meloxicam	30,39	COX-2	13,18	meloxicam	COX-2	MESH:C065757	26198(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Preferential COX-2 inhibitor , meloxicam , compromises renal perfusion in euvolemic and hypovolemic rats .
12174906	0	meloxicam	110,119	COX-2	14,19	meloxicam	COX-2	MESH:C065757	5743	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|Expression Expression|nmod|genes genes|amod|END_ENTITY	Expression of COX-2 and Wnt pathway genes in adenomas of familial_adenomatous_polyposis patients treated with meloxicam .
17074019	0	meloxicam	26,35	COX-2	9,14	meloxicam	COX-2	MESH:C065757	5743	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Specific COX-2 inhibitor , meloxicam , suppresses proliferation and induces apoptosis in human HepG2 hepatocellular_carcinoma cells .
17447009	0	meloxicam	78,87	COX-2	61,66	meloxicam	COX-2	MESH:C065757	4513	Chemical	Gene	START_ENTITY|nsubj|potential potential|nmod|inhibitor inhibitor|appos|END_ENTITY	Radiosensitizing potential of the selective cyclooygenase-2 -LRB- COX-2 -RRB- inhibitor meloxicam on human glioma cells .
17725981	0	meloxicam	14,23	COX-2	37,42	meloxicam	COX-2	MESH:C065757	26198(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	The effect of meloxicam , a selective COX-2 inhibitor , on the microvasculature of small metastatic liver_tumors in rats .
17962388	0	meloxicam	40,49	COX-2	53,58	meloxicam	COX-2	MESH:C065757	808233(Tax:9986)	Chemical	Gene	formulation|nmod|START_ENTITY Effects|nmod|formulation Effects|nmod|expression expression|compound|END_ENTITY	Effects of an ophthalmic formulation of meloxicam on COX-2 expression , PGE2 release , and cytokine expression in a model of acute_ocular_inflammation .
18058818	0	meloxicam	33,42	COX-2	17,22	meloxicam	COX-2	MESH:C065757	4513	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|inhibitor inhibitor|compound|END_ENTITY	The effects of a COX-2 inhibitor meloxicam on squamous_cell_carcinoma of the esophagus in vivo .
19660237	0	meloxicam	26,35	COX-2	10,15	meloxicam	COX-2	MESH:C065757	29527(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|inhibitor inhibitor|compound|END_ENTITY	Effect of COX-2 inhibitor meloxicam against traumatic_brain_injury-induced biochemical , histopathological changes and blood-brain barrier permeability .
19891691	0	meloxicam	92,101	COX-2	70,75	meloxicam	COX-2	MESH:C065757	807936(Tax:9685)	Chemical	Gene	drug|appos|START_ENTITY drug|compound|END_ENTITY	Treatment of feline mammary tumours using chemotherapy , surgery and a COX-2 inhibitor drug -LRB- meloxicam -RRB- : a retrospective study of 23 cases -LRB- 2002-2007 -RRB- * .
8630636	0	meloxicam	16,25	COX-2	137,142	meloxicam	COX-2	MESH:C065757	26198(Tax:10116)	Chemical	Gene	profile|nmod|START_ENTITY profile|nmod|inhibition inhibition|nmod|END_ENTITY	Pharmacology of meloxicam , a new non-steroidal anti-inflammatory drug with an improved safety profile through preferential inhibition of COX-2 .
9243303	0	meloxicam	56,65	COX-2	32,37	meloxicam	COX-2	MESH:C065757	26198(Tax:10116)	Chemical	Gene	preferring|dobj|START_ENTITY END_ENTITY|acl|preferring	Analgesic activity of the novel COX-2 preferring NSAID , meloxicam in mono-arthritic rats : central and peripheral components .
26846471	0	meloxicam	33,42	Cox-2	46,51	meloxicam	Cox-2	MESH:C065757	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	A randomised controlled trial of meloxicam , a Cox-2 inhibitor , to prevent hepatocellular_carcinoma recurrence after initial curative treatment .
14606784	0	meloxicam	14,23	cox-2	27,32	meloxicam	cox-2	MESH:C065757	4513	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Evaluation of meloxicam -LRB- A cox-2 inhibitor -RRB- for management of postoperative endodontic pain : a double-blind placebo-controlled study .
16182328	0	meloxicam	54,63	cyclooxygenase	29,43	meloxicam	cyclooxygenase	MESH:C065757	403544(Tax:9615)	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|inhibitor inhibitor|amod|END_ENTITY	Antineoplastic effect of the cyclooxygenase inhibitor meloxicam on canine osteosarcoma cells .
12105157	0	meloxicam	23,32	cyclooxygenase-2	49,65	meloxicam	cyclooxygenase-2	MESH:C065757	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Efficacy assessment of meloxicam , a preferential cyclooxygenase-2 inhibitor , in acute_coronary_syndromes without ST-segment elevation : the Nonsteroidal Anti-Inflammatory Drugs in Unstable Angina Treatment-2 -LRB- NUT-2 -RRB- pilot study .
15944215	0	meloxicam	21,30	cyclooxygenase-2	34,50	meloxicam	cyclooxygenase-2	MESH:C065757	101823908	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Inhibitory effect of meloxicam , a cyclooxygenase-2 inhibitor , on N-nitrosobis _ -LRB- 2-oxopropyl -RRB- _ amine induced biliary_carcinogenesis in Syrian_hamsters .
17291297	0	meloxicam	188,197	cyclooxygenase-2	20,36	meloxicam	cyclooxygenase-2	MESH:C065757	5743	Chemical	Gene	Comparison|nmod|START_ENTITY Safety|dep|Comparison Safety|nmod|inhibitors inhibitors|amod|END_ENTITY	Safety of selective cyclooxygenase-2 inhibitors and a basic non-steroidal anti-inflammatory drug -LRB- NSAID -RRB- in Japanese patients with NSAID-induced urticaria and/or angioedema : Comparison of meloxicam , etodolac and tiaramide .
18166186	0	meloxicam	42,51	cyclooxygenase-2	14,30	meloxicam	cyclooxygenase-2	MESH:C065757	29527(Tax:10116)	Chemical	Gene	COX-2|nmod|START_ENTITY COX-2|amod|END_ENTITY	Inhibition of cyclooxygenase-2 -LRB- COX-2 -RRB- by meloxicam decreases the incidence of ovarian_hyperstimulation_syndrome in a rat model .
18462380	0	meloxicam	47,56	cyclooxygenase-2	20,36	meloxicam	cyclooxygenase-2	MESH:C065757	29527(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|inhibitor inhibitor|amod|END_ENTITY	Effect of selective cyclooxygenase-2 inhibitor meloxicam on liver fibrosis in rats with ligated common bile ducts .
19498273	0	meloxicam	73,82	cyclooxygenase-2	46,62	meloxicam	cyclooxygenase-2	MESH:C065757	19225(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Demonstration Demonstration|nmod|effects effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Demonstration of antiallodynic effects of the cyclooxygenase-2 inhibitor meloxicam on established diabetic neuropathic_pain in mice .
19933235	0	meloxicam	39,48	cyclooxygenase-2	52,68	meloxicam	cyclooxygenase-2	MESH:C065757	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Suppression of follicular_rupture with meloxicam , a cyclooxygenase-2 inhibitor : potential for emergency contraception .
23388481	0	meloxicam	41,50	cyclooxygenase-2	10,26	meloxicam	cyclooxygenase-2	MESH:C065757	29527(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Effect of cyclooxygenase-2 inhibition by meloxicam , on atrogin-1 and myogenic regulatory factors in skeletal muscle of rats injected with endotoxin .
24263216	0	meloxicam	82,91	cyclooxygenase-2	64,80	meloxicam	cyclooxygenase-2	MESH:C065757	19225(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|nmod|END_ENTITY	Agonist of the adenosine A3 receptor , IB-MECA , and inhibitor of cyclooxygenase-2 , meloxicam , given alone or in a combination early after total body irradiation enhance survival of y-irradiated mice .
24854565	0	meloxicam	52,61	cyclooxygenase-2	21,37	meloxicam	cyclooxygenase-2	MESH:C065757	29527(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Role of preferential cyclooxygenase-2 inhibition by meloxicam in ischemia/reperfusion injury of the rat liver .
9309800	0	meloxicam	41,50	cyclooxygenase-2	140,156	meloxicam	cyclooxygenase-2	MESH:C065757	29527(Tax:10116)	Chemical	Gene	Evaluation|nmod|START_ENTITY Evaluation|nmod|END_ENTITY	Evaluation of pharmacological profile of meloxicam as an anti-inflammatory agent , with particular reference to its relative selectivity for cyclooxygenase-2 over cyclooxygenase-1 .
9680081	0	meloxicam	52,61	cyclooxygenase-2	24,40	meloxicam	cyclooxygenase-2	MESH:C065757	29527(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Tocolytic effect of the cyclooxygenase-2 inhibitor , meloxicam : studies on uterine contractions in the rat .
17582802	0	meloxicam	21,30	peroxisome_proliferator-activated_receptor_gamma	91,139	meloxicam	peroxisome proliferator-activated receptor gamma	MESH:C065757	5468	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Inhibitory effect of meloxicam , a selective cyclooxygenase-2 inhibitor , and ciglitazone , a peroxisome_proliferator-activated_receptor_gamma ligand , on the growth of human ovarian_cancers .
17828495	0	meloxicam	11,20	vascular_endothelial_growth_factor	24,58	meloxicam	vascular endothelial growth factor	MESH:C065757	7422	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of meloxicam on vascular_endothelial_growth_factor and angiopoietin-2 expression in colon_carcinoma cell line HT-29 .
22309430	0	melperone	43,52	CYP2D6	95,101	melperone	CYP2D6	MESH:C008522	1565	Chemical	Gene	augmentation|amod|START_ENTITY augmentation|nmod|patient patient|nmod|END_ENTITY	Successful treatment of schizophrenia with melperone augmentation in a patient with phenotypic CYP2D6 ultrarapid metabolization : a case report .
343747	0	melperone	11,20	prolactin	40,49	melperone	prolactin	MESH:C008522	5617	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|compound|END_ENTITY	Effects of melperone and thiothixene on prolactin levels in cerebrospinal fluid and plasma of psychotic women .
19637344	0	melphalan	54,63	ADH-1	28,33	melphalan	ADH-1	MESH:D008558	124	Chemical	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	A phase 1 study of systemic ADH-1 in combination with melphalan via isolated limb infusion in patients with locally advanced in-transit malignant melanoma .
21343562	0	melphalan	77,86	ADH-1	51,56	melphalan	ADH-1	MESH:D008558	124	Chemical	Gene	trial|nmod|START_ENTITY trial|nmod|END_ENTITY	Prospective multicenter phase II trial of systemic ADH-1 in combination with melphalan via isolated limb infusion in patients with advanced extremity melanoma .
19162187	0	melphalan	71,80	delta-Aminolevulinate_dehydratase	0,33	melphalan	delta-Aminolevulinate dehydratase	MESH:D008558	210	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	delta-Aminolevulinate_dehydratase activity and oxidative stress during melphalan and cyclophosphamide-BCNU-etoposide -LRB- CBV -RRB- conditioning regimens in autologous bone marrow transplantation patients .
15840383	0	melphalan	14,23	glutathione_S-transferase	48,73	melphalan	glutathione S-transferase	MESH:D008558	58962(Tax:10116)	Chemical	Gene	Metabolism|nmod|START_ENTITY microsomal|nsubj|Metabolism microsomal|xcomp|END_ENTITY	Metabolism of melphalan by rat liver microsomal glutathione_S-transferase .
8820431	0	melphalan	16,25	glutathione_S-transferase	59,84	melphalan	glutathione S-transferase	MESH:D008558	373156	Chemical	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of melphalan with glutathione and the role of glutathione_S-transferase .
18022863	0	melphalan	116,125	tumor_necrosis_factor_alpha	51,78	melphalan	tumor necrosis factor alpha	MESH:D008558	21926(Tax:10090)	Chemical	Gene	targeting|nmod|START_ENTITY targeting|dobj|END_ENTITY	Therapy-induced antitumor vaccination by targeting tumor_necrosis_factor_alpha to tumor vessels in combination with melphalan .
19521778	0	memantine	69,78	BDNF	18,22	memantine	BDNF	MESH:D008559	627	Chemical	Gene	effect|nmod|START_ENTITY involvement|nmod|effect involvement|nmod|END_ENTITY	An involvement of BDNF and PI3-K/Akt in the anti-apoptotic effect of memantine on staurosporine-evoked cell death in primary cortical neurons .
23414063	0	memantine	93,102	Brain-derived_neurotrophic_factor	0,33	memantine	Brain-derived neurotrophic factor	MESH:D008559	24225(Tax:10116)	Chemical	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor mediates the suppression of alcohol self-administration by memantine .
8646415	0	memantine	11,20	CA1	123,126	memantine	CA1	MESH:D008559	310218(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of memantine and MK-801 on NMDA-induced currents in cultured neurones and on synaptic transmission and LTP in area CA1 of rat hippocampal slices .
10737358	0	memantine	18,27	acetylcholinesterase	33,53	memantine	acetylcholinesterase	MESH:D008559	43	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	No interaction of memantine with acetylcholinesterase inhibitors approved for clinical use .
11591126	0	memantine	26,35	brain-derived_neurotrophic_factor	44,77	memantine	brain-derived neurotrophic factor	MESH:D008559	24225(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	The neuroprotective agent memantine induces brain-derived_neurotrophic_factor and trkB receptor expression in rat brain .
15378224	0	memantine	22,31	cytochrome_P450	41,56	memantine	cytochrome P450	MESH:D008559	4051	Chemical	Gene	START_ENTITY|nmod|activities activities|amod|END_ENTITY	Inhibitory effects of memantine on human cytochrome_P450 activities : prediction of in vivo drug interactions .
14767721	0	memantine	50,59	nerve_growth_factor	3,22	memantine	nerve growth factor	MESH:D008559	310738(Tax:10116)	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	No nerve_growth_factor response to treatment with memantine in adult rats .
17276010	0	menadione	44,53	Akt	37,40	menadione	Akt	MESH:D024483	207	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of PTEN and activation of Akt by menadione .
1406605	0	menadione	117,126	DT-diaphorase	99,112	menadione	DT-diaphorase	MESH:D024483	24314(Tax:10116)	Chemical	Gene	oxidoreductase|nmod|START_ENTITY oxidoreductase|appos|END_ENTITY	Suggested mechanism for the modulation of the activity of NAD -LRB- P -RRB- H : quinone acceptor oxidoreductase -LRB- DT-diaphorase -RRB- by menadione : interpretation of the effect of menadione on 5 ' - -LSB- p - -LRB- Fluorosulfonyl -RRB- benzoyl -RSB- adenosine labeling of rat liver NAD -LRB- P -RRB- H : quinone acceptor oxidoreductase .
17276010	0	menadione	44,53	PTEN	14,18	menadione	PTEN	MESH:D024483	5728	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of PTEN and activation of Akt by menadione .
22039914	0	menadione	44,53	heme_oxygenase-2	24,40	menadione	heme oxygenase-2	MESH:D024483	3163	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Selective activation of heme_oxygenase-2 by menadione .
10393263	0	menadione	60,69	lacI	86,90	menadione	lacI	MESH:D024483	7035	Chemical	Gene	mutations|amod|START_ENTITY mutations|compound|END_ENTITY	Comparison of selectable and plaque assay systems to detect menadione - and UV-induced lacI mutations in mammalian cells .
11396930	0	menthofuran	19,30	cytochrome_P450_monooxygenase	62,91	menthofuran	cytochrome P450 monooxygenase	MESH:C054487	57404	Chemical	Gene	synthase|compound|START_ENTITY END_ENTITY|nsubj|synthase	Demonstration that menthofuran synthase of mint -LRB- Mentha -RRB- is a cytochrome_P450_monooxygenase : cloning , functional expression , and characterization of the responsible gene .
15190109	0	menthol	20,27	TRPM8	0,5	menthol	TRPM8	MESH:D008610	100754189	Chemical	Gene	activation|nmod|START_ENTITY activation|nummod|END_ENTITY	TRPM8 activation by menthol , icilin , and cold is differentially modulated by intracellular pH. TRPM8 is a nonselective cation channel activated by cold and the cooling compounds menthol and icilin -LRB- Peier et al. , 2002 -RRB- .
20201386	0	menthol	95,102	TRPM8	73,78	menthol	TRPM8	MESH:D008610	171384(Tax:10116)	Chemical	Gene	-RSB-|amod|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Modulation of the smooth muscle contractions of the rat vas deferens by TRPM8 channel agonist menthol -RSB- .
21991571	0	menthol	4,11	TRPM8	40,45	menthol	TRPM8	MESH:D008610	79054	Chemical	Gene	receptor|amod|START_ENTITY END_ENTITY|nsubj|receptor	The menthol and cold sensation receptor TRPM8 in normal human nasal mucosa and rhinitis .
18935911	0	menthone	105,113	interleukin-1beta	41,58	menthone	interleukin-1beta	MESH:C019466	3553	Chemical	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	Inhibition of lipopolysaccharide-induced interleukin-1beta and tumor_necrosis_factor-alpha production by menthone through nuclear factor-kappaB signaling pathway in HaCat cells .
11484413	9	mepacrine	1240,1249	HTSE	1224,1228	mepacrine	PLA2	MESH:D011796	151056	Chemical	Gene	cells|nmod|START_ENTITY cells|amod|END_ENTITY	Treatment of PKC downregulated HTSE cells with mepacrine did not further decrease the ATP-induced mucin release .
2777057	0	mepacrine	61,70	phospholipase_A2	32,48	mepacrine	phospholipase A2	MESH:D011796	151056	Chemical	Gene	properties|amod|START_ENTITY properties|nmod|inhibitors inhibitors|amod|END_ENTITY	Ca2 + - antagonistic properties of phospholipase_A2 inhibitors , mepacrine and chloroquine .
7281105	0	mepacrine	38,47	phospholipase_inhibitor	14,37	mepacrine	phospholipase inhibitor	MESH:D011796	646627	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|END_ENTITY	The effect of phospholipase_inhibitor mepacrine on platelet_aggregation , the platelet release reaction and fibrinogen binding to the platelet surface .
7138896	0	mepacrine	86,95	platelet_phospholipase_A2	23,48	mepacrine	platelet phospholipase A2	MESH:D011796	29692(Tax:10116)	Chemical	Gene	modulation|nmod|START_ENTITY modulation|nmod|activity activity|amod|END_ENTITY	Biphasic modulation of platelet_phospholipase_A2 activity and platelet_aggregation by mepacrine -LRB- quinacrine -RRB- .
9797796	0	mephenytoin	72,83	CYP2C19	105,112	mephenytoin	CYP2C19	MESH:D008617	1557	Chemical	Gene	START_ENTITY|nmod|genotype genotype|compound|END_ENTITY	Bantu Tanzanians have a decreased capacity to metabolize omeprazole and mephenytoin in relation to their CYP2C19 genotype .
22342565	0	mephobarbital	23,36	P-glycoprotein	59,73	mephobarbital	P-glycoprotein	MESH:D008618	67078(Tax:10090)	Chemical	Gene	transported|nsubjpass|START_ENTITY transported|nmod|END_ENTITY	The antiepileptic drug mephobarbital is not transported by P-glycoprotein or multidrug_resistance_protein_1 at the blood-brain barrier : a positron emission tomography study .
3663435	0	meptazinol	36,46	CSF	54,57	meptazinol	CSF	MESH:D008621	1437	Chemical	Gene	Disposition|nmod|START_ENTITY Disposition|nmod|END_ENTITY	Disposition and pharmacokinetics of meptazinol in the CSF .
11903961	0	mepyramine	76,86	CYP2D6	33,39	mepyramine	CYP2D6	MESH:D011738	1565	Chemical	Gene	catalyzed|nmod|START_ENTITY catalyzed|nsubj|inhibition inhibition|nmod|END_ENTITY	Dose-dependent inhibition of the CYP2D6 catalyzed oxidation of sparteine by mepyramine in healthy volunteers .
19149650	0	mercaptoacyldipeptides	66,88	neutral_endopeptidase	111,132	mercaptoacyldipeptides	neutral endopeptidase	null	4311	Chemical	Gene	START_ENTITY|nmod|site site|nmod|END_ENTITY	Receptor-based 3D-QSAR study for recognizing true binding mode of mercaptoacyldipeptides at the active site of neutral_endopeptidase .
11681411	0	mercaptopurine	161,175	thiopurine_S-methyltransferase	24,54	mercaptopurine	thiopurine S-methyltransferase	MESH:D015122	7172	Chemical	Gene	implication|nmod|START_ENTITY implication|nmod|END_ENTITY	Possible implication of thiopurine_S-methyltransferase in occurrence of infectious episodes during maintenance therapy for childhood_lymphoblastic_leukemia with mercaptopurine .
15711095	0	mercuric	39,47	interleukin-4	62,75	mercuric	interleukin-4	null	16189(Tax:10090)	Chemical	Gene	secretion|amod|START_ENTITY secretion|compound|END_ENTITY	c-Jun_N-terminal_kinase is involved in mercuric ions-mediated interleukin-4 secretion in mast cells .
1909117	0	mercuric_chloride	120,137	UDP-glucuronosyltransferase	38,65	mercuric chloride	UDP-glucuronosyltransferase	MESH:D008627	54657	Chemical	Gene	exposure|acl|START_ENTITY Expression|nmod|exposure Expression|nmod|END_ENTITY	Expression of a high-affinity form of UDP-glucuronosyltransferase in human foetal liver cells in culture on exposure to mercuric_chloride .
10447925	0	mercuric_chloride	78,95	interferon-gamma	116,132	mercuric chloride	interferon-gamma	MESH:D008627	25712(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|up-regulation up-regulation|nmod|END_ENTITY	Low-dose mercuric_chloride induces resistance in brown norway_rats to further mercuric_chloride by up-regulation of interferon-gamma .
2272649	0	mercury	55,62	C-reactive_protein	17,35	mercury	C-reactive protein	MESH:D008628	25419(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Possible role of C-reactive_protein in detoxication of mercury .
12173417	0	mercury	30,37	CYP1A1	52,58	mercury	CYP1A1	MESH:D008628	1543	Chemical	Gene	accumulation|nmod|START_ENTITY enhances|nsubj|accumulation enhances|dobj|expression expression|compound|END_ENTITY	Intracellular accumulation of mercury enhances P450 CYP1A1 expression and Cl - currents in cultured shark rectal gland cells .
8642619	0	mercury	101,108	Catalase	0,8	mercury	Catalase	MESH:D008628	847	Chemical	Gene	vapors|compound|START_ENTITY exposed|nmod|vapors workers|acl|exposed stress|nmod|workers stress|nsubj|activities activities|amod|END_ENTITY	Catalase and superoxide dismutase activities as biomarkers of oxidative stress in workers exposed to mercury vapors .
18078826	0	mercury	109,116	Cyp1a1	94,100	mercury	Cyp1a1	MESH:D008628	1543	Chemical	Gene	AP-1|nmod|START_ENTITY AP-1|nmod|modulation modulation|nmod|gene gene|amod|END_ENTITY	The role of redox-sensitive transcription factors NF-kappaB and AP-1 in the modulation of the Cyp1a1 gene by mercury , lead , and copper .
25772431	0	mercury	77,84	DMT1	45,49	mercury	DMT1	MESH:D008628	4891	Chemical	Gene	uptake|nmod|START_ENTITY END_ENTITY|nmod|uptake	Participation of divalent cation transporter DMT1 in the uptake of inorganic mercury .
15183152	0	mercury	24,31	IL-2	54,58	mercury	IL-2	MESH:D008628	3558	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Differential effects of mercury , lead , and cadmium on IL-2 production by Jurkat T cells .
11312036	0	mercury	182,189	JNK1	157,161	mercury	JNK1	MESH:D008628	5599	Chemical	Gene	toxicity|compound|START_ENTITY END_ENTITY|nmod|toxicity	Potentiation of arsenic-induced cytotoxicity by sulfur_amino_acid deprivation -LRB- SAAD -RRB- through activation of ERK1/2 , p38 kinase and JNK1 : the distinct role of JNK1 in SAAD-potentiated mercury toxicity .
16251484	0	mercury	10,17	LAT	45,48	mercury	LAT	MESH:D008628	27040	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	Inorganic mercury inhibits the activation of LAT in T-cell receptor-mediated signal transduction .
769702	0	mercury	24,31	Lymphokine	1,11	mercury	Lymphokine	MESH:D008628	3558	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	-LSB- Lymphokine activity in mercury stimulated leucocyte cultures -LRB- author 's transl -RRB- -RSB- .
9231518	1	mercury	94,101	Part_6	58,64	mercury	Part 6	MESH:D008628	80351	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|dep|effects	Part_6 : Possible harmful effects of mercury from dental amalgam .
2472318	0	mercury	10,17	acetylcholinesterase	98,118	mercury	acetylcholinesterase	MESH:D008628	83817(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of mercury and combined effect of mercury and dimethylsulphoxide -LRB- DMSO -RRB- on the activity of acetylcholinesterase -LRB- AchE-E.C .
6083938	0	mercury	11,18	acetylcholinesterase	22,42	mercury	acetylcholinesterase	MESH:D008628	83817(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of mercury on acetylcholinesterase -LRB- E.C. 3.1.1.7 . -RRB-
15297030	0	mercury	24,31	aryl_hydrocarbon_receptor	97,122	mercury	aryl hydrocarbon receptor	MESH:D008628	11622(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|nmod|END_ENTITY	Differential effects of mercury , lead and copper on the constitutive and inducible expression of aryl_hydrocarbon_receptor -LRB- AHR -RRB- - regulated genes in cultured hepatoma Hepa 1c1c7 cells .
567993	0	mercury	37,44	catalase	8,16	mercury	catalase	MESH:D008628	847	Chemical	Gene	vapor|compound|START_ENTITY oxidation|nmod|vapor Role|nmod|oxidation Role|nmod|END_ENTITY	Role of catalase in the oxidation of mercury vapor .
6643916	0	mercury	13,20	catalase	24,32	mercury	catalase	MESH:D008628	847	Chemical	Gene	Oxidation|nmod|START_ENTITY Oxidation|nmod|END_ENTITY	Oxidation of mercury by catalase and peroxidase in homogeneous solution .
6647575	0	mercury	36,43	catalase	56,64	mercury	catalase	MESH:D008628	847	Chemical	Gene	mechanism|nmod|START_ENTITY mechanism|acl|vitro vitro|nmod|END_ENTITY	The oxidation mechanism of metallic mercury in vitro by catalase .
6704166	0	mercury	22,29	catalase	52,60	mercury	catalase	MESH:D008628	847	Chemical	Gene	Mechanism|nmod|START_ENTITY oxidation|nsubj|Mechanism oxidation|advcl|vitro vitro|nmod|END_ENTITY	Mechanism of metallic mercury oxidation in vitro by catalase and peroxidase .
6846030	0	mercury	63,70	catalase	21,29	mercury	catalase	MESH:D008628	24248(Tax:10116)	Chemical	Gene	Relationship|nmod|START_ENTITY Relationship|nmod|activity activity|amod|END_ENTITY	Relationship between catalase activity and uptake of elemental mercury by rat brain .
7180501	0	mercury	20,27	catalase	44,52	mercury	catalase	MESH:D008628	24248(Tax:10116)	Chemical	Gene	Uptake|nmod|START_ENTITY Uptake|nmod|END_ENTITY	Uptake of elemental mercury and activity of catalase in rat , hamster , guinea-pig , normal and acatalasemic mice .
6106975	0	mercury	60,67	gamma-glutamyl_transferase	8,34	mercury	gamma-glutamyl transferase	MESH:D008628	116568(Tax:10116)	Chemical	Gene	marker|nmod|START_ENTITY END_ENTITY|nmod|marker	Urinary gamma-glutamyl_transferase as a specific marker for mercury after heavy metal treatment of rats .
41104	0	mercury	22,29	glucose-6-phosphate_dehydrogenase	48,81	mercury	glucose-6-phosphate dehydrogenase	MESH:D008628	855480(Tax:4932)	Chemical	Gene	actions|nmod|START_ENTITY compounds|nsubj|actions compounds|advcl|END_ENTITY	Inhibitory actions of mercury compounds against glucose-6-phosphate_dehydrogenase from yeast .
6157628	0	mercury	10,17	glucose-6-phosphate_dehydrogenase	88,121	mercury	glucose-6-phosphate dehydrogenase	MESH:D008628	24377(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of mercury , lead and acetylphenylhydrazine -LRB- APHZ -RRB- on erythrocyte and bone marrow glucose-6-phosphate_dehydrogenase -LRB- E.C. 1.1.1.49 -RRB- .
20226812	0	mercury_chloride	13,29	adenosine_deaminase	33,52	mercury chloride	adenosine deaminase	null	436919(Tax:7955)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Influence of mercury_chloride on adenosine_deaminase activity and gene expression in zebrafish -LRB- Danio_rerio -RRB- brain .
11953161	0	merozoite	66,75	MSP1	93,97	merozoite	MSP1	null	813575(Tax:36329)	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	-LSB- Synthesis and expression of 42 kD C-terminal region of the major merozoite surface protein -LRB- MSP1 - 42 -RRB- of P. _ falciparum_3D7_strain in pichia_pastoris -RSB- .
1850465	0	mersalyl	79,87	renin	37,42	mersalyl	renin	MESH:D008634	100358545(Tax:9986)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|mechanism mechanism|nmod|stimulation stimulation|nmod|END_ENTITY	Cellular mechanism of stimulation of renin secretion by the mercurial diuretic mersalyl .
18473409	0	mesalamine	34,44	N-acetyl-L-cysteine	0,19	mesalamine	N-acetyl-L-cysteine	MESH:D019804	7504	Chemical	Gene	combined|nmod|START_ENTITY END_ENTITY|acl|combined	N-acetyl-L-cysteine combined with mesalamine in the treatment of ulcerative_colitis : randomized , placebo-controlled pilot study .
9352849	0	mesalamine	11,21	hsp72	29,34	mesalamine	hsp72	MESH:D019804	24472(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|response response|amod|END_ENTITY	Effects of mesalamine on the hsp72 stress response in rat IEC-18 intestinal epithelial cells .
116281	0	mescaline	44,53	prolactin	21,30	mescaline	prolactin	MESH:D008635	5617	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Stimulation Stimulation|nmod|END_ENTITY	Stimulation of human prolactin secretion by mescaline .
21963507	0	meso-Dihydroguaiaretic_acid	0,27	AMP-activated_protein_kinase	78,106	meso-Dihydroguaiaretic acid	AMP-activated protein kinase	MESH:C015816	5563	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|activating activating|dobj|END_ENTITY	meso-Dihydroguaiaretic_acid inhibits hepatic_lipid_accumulation by activating AMP-activated_protein_kinase in human HepG2 cells .
17983657	0	meso-diaminopimelic_acid	142,166	nucleotide-binding_oligomerization_domain-1	61,104	meso-diaminopimelic acid	nucleotide-binding oligomerization domain-1	null	100135660(Tax:9823)	Chemical	Gene	agonists|amod|START_ENTITY agonists|amod|END_ENTITY	Molecular cloning and functional characterization of porcine nucleotide-binding_oligomerization_domain-1 -LRB- NOD1 -RRB- recognizing minimum agonists , meso-diaminopimelic_acid and meso-lanthionine .
9553808	0	mesothelium	30,41	Desmin	0,6	mesothelium	Desmin	null	1674	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Desmin expression in reactive mesothelium : a potential aid in evaluation of gynecologic specimens .
2420101	0	mestranol	11,20	PRL	75,78	mestranol	PRL	MESH:D008656	5617	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	-LSB- Effect of mestranol and chlormadinone_acetate on basal and TRH-stimulated PRL secretion in Turner 's _ syndrome -RSB- .
2866128	0	met-enkephalin	14,28	somatostatin	45,57	met-enkephalin	somatostatin	MESH:D004744	24797(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|compound|END_ENTITY	The effect of met-enkephalin and naloxone on somatostatin and insulin secretion from the isolated , perfused rat pancreas .
2706736	0	meta-azidopyrimethamine_ethanesulphonate	19,59	dihydrofolate_reductase	75,98	meta-azidopyrimethamine ethanesulphonate	dihydrofolate reductase	null	1719	Chemical	Gene	study|nmod|START_ENTITY study|dep|inhibitor inhibitor|compound|END_ENTITY	A phase I study of meta-azidopyrimethamine_ethanesulphonate -LRB- MZPES -RRB- -- a new dihydrofolate_reductase inhibitor .
16418827	0	meta-chlorophenylpiperazine	78,105	prolactin	56,65	meta-chlorophenylpiperazine	prolactin	MESH:C015068	5617	Chemical	Gene	blunted|advcl|START_ENTITY blunted|dobj|response response|compound|END_ENTITY	Relationship of disinhibition and aggression to blunted prolactin response to meta-chlorophenylpiperazine in cocaine-dependent patients .
18321529	0	meta-chlorophenylpiperazine	69,96	serotonin_transporter	20,41	meta-chlorophenylpiperazine	serotonin transporter	MESH:C015068	6532	Chemical	Gene	Relationship|acl|START_ENTITY Relationship|nmod|END_ENTITY	Relationship of the serotonin_transporter with prolactin response to meta-chlorophenylpiperazine in cocaine dependence .
2754760	0	metalaxyl	49,58	monoamine_oxidase	14,31	metalaxyl	monoamine oxidase	CHEBI:60607	29253(Tax:10116)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of monoamine_oxidase by the fungicide metalaxyl .
11524675	0	metallochaperone	68,84	superoxide_dismutase	27,47	metallochaperone	superoxide dismutase	null	853568(Tax:4932)	Chemical	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Heterodimeric structure of superoxide_dismutase in complex with its metallochaperone .
9070867	0	metalloporphyrins	29,46	HBP_23	19,25	metalloporphyrins	HBP 23	MESH:D008665	117254(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Gene regulation of HBP_23 by metalloporphyrins and protoporphyrin_IX in liver and hepatocyte cultures .
11440730	0	metamizol	11,20	glucose_6-phosphate_dehydrogenase	65,98	metamizol	glucose 6-phosphate dehydrogenase	MESH:D004177	2539	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of metamizol and magnesium_sulfate on enzyme activity of glucose_6-phosphate_dehydrogenase from human erythrocyte in vitro and rat erythrocyte in vivo .
16470514	0	metanephrine	45,57	catechol-O-methyltransferase	62,90	metanephrine	catechol-O-methyltransferase	MESH:D008676	1312	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	The effect of temperature on the analysis of metanephrine for catechol-O-methyltransferase activity assay by HPLC with electrochemical detection .
9914169	0	metargidin	15,25	ADAM-15	27,34	metargidin	ADAM-15	null	8751	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|appos|END_ENTITY	Interaction of metargidin -LRB- ADAM-15 -RRB- with alphavbeta3 and alpha5beta1 integrins on different haemopoietic cells .
20460434	5	meteorin	849,857	STAT3	868,873	meteorin	STAT3	null	6774	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	In cultured neurospheres , meteorin activates STAT3 , and in turn increases the transcriptional activity of GFAP by enhancing the binding of STAT3 to the promoter .
1002821	0	metergoline	71,82	Growth_hormone	0,14	metergoline	Growth hormone	MESH:D008711	2688	Chemical	Gene	administration|amod|START_ENTITY release|nmod|administration release|compound|END_ENTITY	Growth_hormone and prolactin release in acromegalic patients following metergoline administration .
1261961	0	metergoline	10,21	growth_hormone	65,79	metergoline	growth hormone	MESH:D008711	2688	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|response response|compound|END_ENTITY	Effect of metergoline , a specific serotonin antagonist , on human growth_hormone response to arginine and L-dopa .
6106165	0	metergoline	136,147	growth_hormone	86,100	metergoline	growth hormone	MESH:D008711	81668(Tax:10116)	Chemical	Gene	injection|nmod|START_ENTITY produced|nmod|injection secretion|acl|produced secretion|compound|END_ENTITY	Administration of antisomatostatin serum to rats reverses the inhibition of pulsatile growth_hormone secretion produced by injection of metergoline but not yohimbine .
6773980	0	metergoline	117,128	growth_hormone	10,24	metergoline	growth hormone	MESH:D008711	2688	Chemical	Gene	effect|nmod|START_ENTITY responses|dep|effect responses|compound|END_ENTITY	Anomalous growth_hormone responses to thyrotropin-releasing_hormone and glucose in cirrhotic patients : the effect of metergoline .
1149950	0	metergoline	10,21	insulin	79,86	metergoline	insulin	MESH:D008711	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of metergoline , a powerful and long-acting antiserotoninergic agent , on insulin secretion in normal subjects and in patients with chemical diabetes .
6819905	0	metergoline	12,23	prolactin	43,52	metergoline	prolactin	MESH:D008711	5617	Chemical	Gene	START_ENTITY|nmod|levels levels|nmod|END_ENTITY	-LSB- Effects of metergoline on serum levels of prolactin and gonadotropin in women -RSB- .
849985	0	metergoline	10,21	prolactin	37,46	metergoline	prolactin	MESH:D008711	5617	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	Action of metergoline in suppressing prolactin release induced by mechanical breast emptying .
6773980	0	metergoline	117,128	thyrotropin-releasing_hormone	38,67	metergoline	thyrotropin-releasing hormone	MESH:D008711	7200	Chemical	Gene	effect|nmod|START_ENTITY responses|dep|effect responses|nmod|END_ENTITY	Anomalous growth_hormone responses to thyrotropin-releasing_hormone and glucose in cirrhotic patients : the effect of metergoline .
20189560	0	metformin	70,79	Adiponectin	0,11	metformin	Adiponectin	MESH:D008687	9370	Chemical	Gene	treatment|compound|START_ENTITY impact|nmod|treatment levels|dep|impact levels|compound|END_ENTITY	Adiponectin levels in women with polycystic_ovary_syndrome : impact of metformin treatment in a randomized controlled study .
24906976	0	metformin	128,137	Adiponectin	0,11	metformin	Adiponectin	MESH:D008687	9370	Chemical	Gene	treatment|nmod|START_ENTITY mass|nmod|treatment mass|amod|fat fat|dep|END_ENTITY	Adiponectin , interleukin-6 , monocyte_chemoattractant_protein-1 , and regional fat mass during 12-month randomized treatment with metformin and/or oral contraceptives in polycystic_ovary_syndrome .
22406377	7	metformin	1099,1108	Bambi	1119,1124	metformin	AICAR	MESH:D008687	471	Chemical	Gene	increased|nsubj|START_ENTITY increased|dobj|expression expression|compound|END_ENTITY	AICAR-mediated HSC cell death was paralleled by loss of expression of the TGF-b decoy receptor Bambi , whereas metformin increased Bambi expression .
12721499	0	metformin	10,19	C-reactive_protein	40,58	metformin	C-reactive protein	MESH:D008687	1401	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|level level|amod|END_ENTITY	Effect of metformin and sulfonylurea on C-reactive_protein level in well-controlled type 2 diabetics with metabolic_syndrome .
16500361	0	metformin	21,30	C-reactive_protein	132,150	metformin	C-reactive protein	MESH:D008687	1401	Chemical	Gene	effect|nmod|START_ENTITY associated|nsubjpass|effect associated|nmod|changes changes|nmod|levels levels|amod|END_ENTITY	Beneficial effect of metformin on pregnancy outcome in women with polycystic_ovary_syndrome is not associated with major changes in C-reactive_protein levels or indices of coagulation .
17489777	0	metformin	57,66	C-reactive_protein	0,18	metformin	C-reactive protein	MESH:D008687	1401	Chemical	Gene	therapy|compound|START_ENTITY END_ENTITY|nmod|therapy	C-reactive_protein in obese_PCOS women and the effect of metformin therapy .
17548076	0	metformin	44,53	C-reactive_protein	0,18	metformin	C-reactive protein	MESH:D008687	1401	Chemical	Gene	unaffected|nmod|START_ENTITY unaffected|nsubj|levels levels|amod|END_ENTITY	C-reactive_protein levels are unaffected by metformin during pretreatment and an IVF cycle in women with polycystic_ovary_syndrome .
19488607	0	metformin	26,35	C-reactive_protein	223,241	metformin	C-reactive protein	MESH:D008687	1401	Chemical	Gene	treatment|nmod|START_ENTITY improves|nsubj|treatment improves|nmod|relatives relatives|nmod|subjects subjects|nmod|type_2_diabetes_mellitus type_2_diabetes_mellitus|acl:relcl|have have|nmod|changes changes|nmod|END_ENTITY	Short-term treatment with metformin improves the cardiovascular risk profile in first-degree relatives of subjects with type_2_diabetes_mellitus who have a metabolic_syndrome and normal_glucose_tolerance without changes in C-reactive_protein or fibrinogen .
23279603	0	metformin	10,19	C-reactive_protein	60,78	metformin	C-reactive protein	MESH:D008687	1401	Chemical	Gene	Effect|nmod|START_ENTITY compared|nsubj|Effect compared|nmod|level level|compound|END_ENTITY	Effect of metformin compared with hypocaloric diet on serum C-reactive_protein level and insulin resistance in obese and overweight women with polycystic_ovary_syndrome .
25142987	0	metformin	12,21	CA125	39,44	metformin	CA125	MESH:D008687	94025	Chemical	Gene	therapy|compound|START_ENTITY therapy|nmod|levels levels|compound|END_ENTITY	-LSB- Effects of metformin therapy on serum CA125 levels and its related factors in type 2 diabetics -RSB- .
21109968	0	metformin	23,32	CD24	78,82	metformin	CD24	MESH:D008687	100133941	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	The anti-diabetic drug metformin suppresses the metastasis-associated protein CD24 in MDA-MB-468 triple-negative breast_cancer cells .
16940989	0	metformin	148,157	CYP2C11	103,110	metformin	CYP2C11	MESH:D008687	29277(Tax:10116)	Chemical	Gene	metabolism|nmod|START_ENTITY involvement|nmod|metabolism involvement|nmod|END_ENTITY	Effects of enzyme inducers and inhibitors on the pharmacokinetics of metformin in rats : involvement of CYP2C11 , 2D1 and 3A1/2 for the metabolism of metformin .
24837407	0	metformin	107,116	DPP-4	17,22	metformin	DPP-4	MESH:D008687	1803	Chemical	Gene	inhibitor|nmod|START_ENTITY inhibitor|nsubj|END_ENTITY	Vildagliptin , a DPP-4 inhibitor for the twice-daily treatment of type_2_diabetes_mellitus with or without metformin .
23873427	0	metformin	101,110	FGF-21	114,120	metformin	FGF-21	MESH:D008687	26291	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Changes of plasma fibroblast_growth_factor-21 -LRB- FGF-21 -RRB- in oral glucose tolerance test and effects of metformin on FGF-21 levels in type_2_diabetes_mellitus .
25310131	0	metformin	11,20	FOXM1	24,29	metformin	FOXM1	MESH:D008687	2305	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of metformin on FOXM1 expression and on the biological behavior of acute_leukemia cell lines .
24676803	0	metformin	43,52	FoxM1	10,15	metformin	FoxM1	MESH:D008687	2305	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|expression expression|amod|END_ENTITY	Increased FoxM1 expression is a target for metformin in the suppression of EMT in prostate_cancer .
11289473	0	metformin	10,19	GLP-1	48,53	metformin	GLP-1	MESH:D008687	2641	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of metformin on glucagon-like_peptide_1 -LRB- GLP-1 -RRB- and leptin levels in obese nondiabetic subjects .
11883961	7	metformin	982,991	GLP-1	1010,1015	metformin	DP IV	MESH:D008687	1803	Chemical	Gene	had|nsubj|START_ENTITY had|dobj|effect effect|nmod|END_ENTITY	In addition , surface plasmon resonance was used to establish whether or not metformin had any effect on GLP-1 -LRB- -LSB- 7-36NH2 -RSB- -RRB- or GLP-1 -LRB- -LSB- 9-36NH2 -RSB- -RRB- interaction with immobilized porcine or human DP_IV .
20536952	0	metformin	125,134	GLP-1	75,80	metformin	GLP-1	MESH:D008687	100125288	Chemical	Gene	treated|nmod|START_ENTITY Safety|acl|treated Safety|nmod|taspoglutide taspoglutide|appos|analogue analogue|compound|END_ENTITY	Safety and tolerability of high doses of taspoglutide , a once-weekly human GLP-1 analogue , in diabetic patients treated with metformin : a randomized double-blind placebo-controlled study .
21048706	0	metformin	67,76	GLP-1	146,151	metformin	GLP-1	MESH:D008687	14526(Tax:10090)	Chemical	Gene	result|compound|START_ENTITY administered|nmod|result administered|nmod|increase increase|nmod|concentration concentration|nmod|END_ENTITY	Dipeptidyl_peptidase-4 inhibitors administered in combination with metformin result in an additive increase in the plasma concentration of active GLP-1 .
21116606	0	metformin	28,37	GLP-1	68,73	metformin	GLP-1	MESH:D008687	14526(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|enhancer enhancer|appos|END_ENTITY	New aspects of an old drug : metformin as a glucagon-like_peptide_1 -LRB- GLP-1 -RRB- enhancer and sensitiser .
23280862	0	metformin	57,66	GLP-1	125,130	metformin	GLP-1	MESH:D008687	2641	Chemical	Gene	DPP-IV|amod|START_ENTITY DPP-IV|dep|inhibitors inhibitors|nmod|END_ENTITY	Second line therapy : type 2 diabetic subjects failing on metformin GLP-1 / DPP-IV inhibitors versus sulphonylurea/insulin : for GLP-1 / DPP-IV inhibitors .
23280862	0	metformin	57,66	GLP-1	67,72	metformin	GLP-1	MESH:D008687	2641	Chemical	Gene	DPP-IV|amod|START_ENTITY DPP-IV|compound|END_ENTITY	Second line therapy : type 2 diabetic subjects failing on metformin GLP-1 / DPP-IV inhibitors versus sulphonylurea/insulin : for GLP-1 / DPP-IV inhibitors .
25028601	0	metformin	52,61	GLP-1	77,82	metformin	GLP-1	MESH:D008687	14526(Tax:10090)	Chemical	Gene	START_ENTITY|advcl|circulating circulating|dobj|END_ENTITY	Effects of high-fat diet and the anti-diabetic drug metformin on circulating GLP-1 and the relative number of intestinal L-cells .
25172519	0	metformin	48,57	GLP-1	93,98	metformin	GLP-1	MESH:D008687	100125288	Chemical	Gene	GLP-1|nmod|START_ENTITY diabetes|amod|GLP-1 increase|nmod|diabetes Mechanism|nmod|increase Mechanism|dep|stimulation stimulation|nmod|secretion secretion|compound|END_ENTITY	Mechanism of increase in plasma intact GLP-1 by metformin in type 2 diabetes : stimulation of GLP-1 secretion or reduction in plasma DPP-4 activity ?
26301063	0	metformin	150,159	GLP-1	66,71	metformin	GLP-1	MESH:D008687	100125288	Chemical	Gene	controlled|nmod|START_ENTITY controlled|nsubj|preference preference|nmod|inhibitor inhibitor|nmod|analog analog|compound|END_ENTITY	Patient preference and tolerability of a DPP-4 inhibitor versus a GLP-1 analog in patients with type_2_diabetes_mellitus inadequately controlled with metformin : a 24-week , randomized , multicenter , crossover study .
26990378	0	metformin	100,109	GLP-1	185,190	metformin	GLP-1	MESH:D008687	100125288	Chemical	Gene	controlled|nmod|START_ENTITY controlled|dobj|trial trial|appos|BEGIN BEGIN|dep|Study Study|compound|END_ENTITY	The effect of adding insulin degludec in patients with type 2 diabetes inadequately controlled with metformin and liraglutide : a double-blind randomized controlled trial -LRB- BEGIN : ADD TO GLP-1 Study -RRB- .
20583965	0	metformin	13,22	GLUT1	26,31	metformin	GLUT1	MESH:D008687	24778(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Influence of metformin on GLUT1 gene and protein expression in rat streptozotocin diabetes_mellitus model .
16513829	0	metformin	10,19	GLUT4	136,141	metformin	GLUT4	MESH:D008687	6517	Chemical	Gene	stimulates|compound|START_ENTITY cardiomyocyte|nsubj|stimulates cardiomyocyte|nmod|reduction reduction|nmod|endocytosis endocytosis|nummod|END_ENTITY	Long-term metformin treatment stimulates cardiomyocyte glucose transport through an AMP-activated protein kinase-dependent reduction in GLUT4 endocytosis .
22572996	0	metformin	11,20	GLUT4	42,47	metformin	GLUT4	MESH:D008687	6517	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of metformin on the expression of GLUT4 in endometrium of obese women with polycystic_ovary_syndrome .
26045896	0	metformin	113,122	GLUT4	43,48	metformin	GLUT4	MESH:D008687	6517	Chemical	Gene	action|compound|START_ENTITY study|nmod|action level|dep|study level|nmod|expression expression|compound|END_ENTITY	Reversing the reduced level of endometrial GLUT4 expression in polycystic_ovary_syndrome : a mechanistic study of metformin action .
19106626	0	metformin	22,31	HER2	43,47	metformin	HER2	MESH:D008687	2064	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|overexpression overexpression|compound|END_ENTITY	The antidiabetic drug metformin suppresses HER2 -LRB- erbB-2 -RRB- oncoprotein overexpression via inhibition of the mTOR effector p70S6K1 in human breast_carcinoma cells .
26581908	0	metformin	22,31	HER2	68,72	metformin	HER2	MESH:D008687	2064	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Anti-cancer effect of metformin by suppressing signaling pathway of HER2 and HER3 in tamoxifen-resistant breast_cancer cells .
23111552	0	metformin	37,46	IL-10	72,77	metformin	IL-10	MESH:D008687	25325(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|effect effect|nmod|END_ENTITY	Gemfibrozil and its combination with metformin on pleiotropic effect on IL-10 and adiponectin and anti-atherogenic treatment in insulin resistant type 2 diabetes_mellitus rats .
11597618	0	metformin	122,131	Insulin	0,7	metformin	Insulin	MESH:D008687	3630	Chemical	Gene	resistance|nmod|START_ENTITY resistance|compound|END_ENTITY	Insulin resistance in clomiphene responders and non-responders with polycystic_ovarian_disease and therapeutic effects of metformin .
15032652	0	metformin	78,87	Insulin	0,7	metformin	Insulin	MESH:D008687	3630	Chemical	Gene	resistance|dep|START_ENTITY resistance|compound|END_ENTITY	Insulin resistance as a therapeutic target for improved endothelial function : metformin .
15356029	0	metformin	172,181	Insulin	0,7	metformin	Insulin	MESH:D008687	3630	Chemical	Gene	treatment|compound|START_ENTITY initiation|nmod|treatment effects|nmod|initiation sensitization|dep|effects sensitization|compound|END_ENTITY	Insulin sensitization for girls with precocious_pubarche and with risk for polycystic_ovary_syndrome : effects of prepubertal initiation and postpubertal discontinuation of metformin treatment .
16456680	0	metformin	38,47	Insulin	0,7	metformin	Insulin	MESH:D008687	3630	Chemical	Gene	glargine|advcl|START_ENTITY glargine|nsubj|END_ENTITY	Insulin glargine or NPH combined with metformin in type 2 diabetes : the LANMET study .
16918591	0	metformin	168,177	Insulin	0,7	metformin	Insulin	MESH:D008687	3630	Chemical	Gene	subjects|nmod|START_ENTITY sensitivity|dobj|subjects sensitivity|nsubj|END_ENTITY	Insulin sensitivity during oral glucose tolerance test and its relations to parameters of glucose metabolism and endothelial function in type 2 diabetic subjects under metformin and thiazolidinedione .
17519312	0	metformin	26,35	Insulin	0,7	metformin	Insulin	MESH:D008687	3630	Chemical	Gene	suspension|compound|START_ENTITY sensitivity|nmod|suspension sensitivity|nsubj|END_ENTITY	Insulin sensitivity after metformin suspension in normal-weight women with polycystic_ovary_syndrome .
17941873	0	metformin	52,61	Insulin	162,169	metformin	Insulin	MESH:D008687	3630	Chemical	Gene	START_ENTITY|nmod|type_2_diabetes_mellitus type_2_diabetes_mellitus|dep|END_ENTITY	Addition of biphasic insulin aspart 30 to optimized metformin and pioglitazone treatment of type_2_diabetes_mellitus : The ACTION Study -LRB- Achieving Control Through Insulin plus Oral ageNts -RRB- .
22683131	0	metformin	108,117	Insulin	0,7	metformin	Insulin	MESH:D008687	3630	Chemical	Gene	uncontrolled|nmod|START_ENTITY patients|nmod|uncontrolled glargine|nmod|patients glargine|compound|END_ENTITY	Insulin glargine versus sitagliptin in insulin-naive patients with type_2_diabetes_mellitus uncontrolled on metformin -LRB- EASIE -RRB- : a multicentre , randomised open-label trial .
24069859	0	metformin	120,129	Insulin	0,7	metformin	Insulin	MESH:D008687	3630	Chemical	Gene	treatment|compound|START_ENTITY impact|nmod|treatment assessment|dep|impact assessment|compound|END_ENTITY	Insulin resistance assessment in patients with polycystic_ovary_syndrome using different diagnostic criteria -- impact of metformin treatment .
26592507	0	metformin	28,37	Insulin	0,7	metformin	Insulin	MESH:D008687	3630	Chemical	Gene	therapies|compound|START_ENTITY role|nmod|therapies resistance|appos|role resistance|compound|END_ENTITY	Insulin resistance , role of metformin and other non-insulin therapies in pediatric type 1 diabetes .
6360756	0	metformin	90,99	Insulin_receptor	0,16	metformin	Insulin receptor	MESH:D008687	3643	Chemical	Gene	treatment|compound|START_ENTITY END_ENTITY|nmod|treatment	Insulin_receptor binding to monocytes , insulin secretion , and glucose tolerance following metformin treatment .
16952573	0	metformin	48,57	LKB1	8,12	metformin	LKB1	MESH:D008687	6794	Chemical	Gene	targets|nmod|START_ENTITY targets|nsubj|END_ENTITY	Neither LKB1 nor AMPK are the direct targets of metformin .
17476361	0	metformin	74,83	OCT1	65,69	metformin	OCT1	MESH:D008687	20517(Tax:10090)	Chemical	Gene	action|compound|START_ENTITY Effect|nmod|action Effect|appos|END_ENTITY	Effect of genetic variation in the organic_cation_transporter_1 -LRB- OCT1 -RRB- on metformin action .
17609683	0	metformin	74,83	OCT1	65,69	metformin	OCT1	MESH:D008687	6580	Chemical	Gene	pharmacokinetics|compound|START_ENTITY Effect|nmod|pharmacokinetics Effect|nmod|END_ENTITY	Effect of genetic variation in the organic_cation_transporter_1 , OCT1 , on metformin pharmacokinetics .
19536068	0	metformin	119,128	OCT1	72,76	metformin	OCT1	MESH:D008687	6580	Chemical	Gene	clearance|nmod|START_ENTITY transporters|nmod|clearance transporters|dobj|END_ENTITY	The effects of genetic polymorphisms in the organic cation transporters OCT1 , OCT2 , and OCT3 on the renal clearance of metformin .
20567254	0	metformin	97,106	OCT1	76,80	metformin	OCT1	MESH:D008687	6580	Chemical	Gene	interactions|compound|START_ENTITY predictions|nmod|interactions effects|dep|predictions effects|nmod|inhibitors inhibitors|nmod|transporter transporter|appos|END_ENTITY	Genotype-dependent effects of inhibitors of the organic cation transporter , OCT1 : predictions of metformin interactions .
20956498	0	metformin	60,69	OCT1	0,4	metformin	OCT1	MESH:D008687	6580	Chemical	Gene	action|compound|START_ENTITY contribute|nmod|action contribute|nsubj|Expression Expression|compound|END_ENTITY	OCT1 Expression in adipocytes could contribute to increased metformin action in obese subjects .
21270793	0	metformin	49,58	OCT1	73,77	metformin	OCT1	MESH:D008687	6580	Chemical	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Rifampin enhances the glucose-lowering effect of metformin and increases OCT1 mRNA levels in healthy participants .
25939711	0	metformin	33,42	OCT1	65,69	metformin	OCT1	MESH:D008687	6580	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY independent|nsubj|pharmacokinetics independent|nmod|genotype genotype|compound|END_ENTITY	Steady-state pharmacokinetics of metformin is independent of the OCT1 genotype in healthy volunteers .
26464716	0	metformin	56,65	OCT1	20,24	metformin	OCT1	MESH:D008687	6580	Chemical	Gene	influence|advcl|START_ENTITY influence|nsubj|variants variants|nmod|END_ENTITY	Genetic variants of OCT1 influence glycemic response to metformin in Han Chinese patients with type-2_diabetes_mellitus in Shanghai .
19002567	0	metformin	31,40	Oct1	72,76	metformin	Oct1	MESH:D008687	24904(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Reduced antidiabetic effect of metformin and down-regulation of hepatic Oct1 in rats with ethynylestradiol-induced cholestasis .
26733176	0	metformin	86,95	P-glycoprotein	10,24	metformin	P-glycoprotein	MESH:D008687	5243	Chemical	Gene	combination|nmod|START_ENTITY expression|dep|combination expression|amod|END_ENTITY	Targeting P-glycoprotein expression and cancer cell energy metabolism : combination of metformin and 2-deoxyglucose reverses the multidrug resistance of K562/Dox cells to doxorubicin .
16169420	0	metformin	56,65	Plasminogen_activator_inhibitor_1	0,33	metformin	Plasminogen activator inhibitor 1	MESH:D008687	5054	Chemical	Gene	treatment|compound|START_ENTITY END_ENTITY|nmod|treatment	Plasminogen_activator_inhibitor_1 and miscarriage after metformin treatment and laparoscopic ovarian_drilling in patients with polycystic_ovary_syndrome .
1174086	0	metformin	86,95	Proinsulin	1,11	metformin	Proinsulin	MESH:D008687	3630	Chemical	Gene	-RSB-|compound|START_ENTITY administration|nmod|-RSB- secretion|nmod|administration secretion|nsubj|END_ENTITY	-LSB- Proinsulin and insulin secretion in obese females before and after administration of metformin -RSB- .
24549596	0	metformin	113,122	Proinsulin	0,10	metformin	Proinsulin	MESH:D008687	3630	Chemical	Gene	treatment|compound|START_ENTITY effect|nmod|treatment END_ENTITY|dep|effect	Proinsulin , adiponectin and hsCRP in reproductive age women with polycystic_ovary_syndrome -LRB- PCOS -RRB- -- the effect of metformin treatment .
24094981	0	metformin	121,130	Resistin	0,8	metformin	Resistin	MESH:D008687	56729	Chemical	Gene	treated|nmod|START_ENTITY patient|acl|treated affect|nmod|patient affect|nsubj|END_ENTITY	Resistin , an adipokine , may affect the improvement_of_insulin_sensitivity in the metabolic_syndrome patient treated with metformin .
24071688	0	metformin	11,20	SIRT1	42,47	metformin	SIRT1	MESH:D008687	309757(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of metformin on the expression of SIRT1 and UCP2 in rat liver of type_2_diabetes_mellitus and nonalcoholic_fatty_liver -RSB- .
26708162	0	metformin	27,36	TLR4	115,119	metformin	TLR4	MESH:D008687	29260(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Cardioprotective effect of metformin in lipopolysaccharide-induced sepsis via suppression of toll-like_receptor_4 -LRB- TLR4 -RRB- in heart .
26956973	0	metformin	59,68	Tristetraprolin	0,15	metformin	Tristetraprolin	MESH:D008687	7538	Chemical	Gene	effects|nmod|START_ENTITY mediates|dobj|effects mediates|nsubj|END_ENTITY	Tristetraprolin mediates the anti-proliferative effects of metformin in breast_cancer cells .
18358555	0	metformin	14,23	VEGF	37,41	metformin	VEGF	MESH:D008687	7422	Chemical	Gene	treatment|compound|START_ENTITY effect|nmod|treatment effect|nmod|levels levels|compound|END_ENTITY	The effect of metformin treatment on VEGF and PAI-1 levels in obese_type_2 diabetic patients .
23315983	0	metformin	62,71	Visfatin	0,8	metformin	Visfatin	MESH:D008687	10135	Chemical	Gene	regulation|nmod|START_ENTITY cells|dep|regulation expressed|nmod|cells expressed|nsubjpass|END_ENTITY	Visfatin is expressed in human granulosa cells : regulation by metformin through AMPK/SIRT1 pathways and its role in steroidogenesis .
25138574	0	metformin	23,32	YKL-40	53,59	metformin	YKL-40	MESH:D008687	1116	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Comparative effects of metformin and pioglitazone on YKL-40 in type 2 diabetes : a randomized clinical trial .
17525501	0	metformin	10,19	adiponectin	38,49	metformin	adiponectin	MESH:D008687	9370	Chemical	Gene	therapy|compound|START_ENTITY therapy|nmod|END_ENTITY	Effect of metformin therapy on plasma adiponectin and leptin levels in obese and insulin resistant postmenopausal females with type 2 diabetes .
21372608	0	metformin	32,41	adiponectin	66,77	metformin	adiponectin	MESH:D008687	9370	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nmod|effects	In vitro and in vivo effects of metformin on human adipose tissue adiponectin .
21862237	0	metformin	109,118	adiponectin	96,107	metformin	adiponectin	MESH:D008687	9370	Chemical	Gene	rapamycin|dep|START_ENTITY rapamycin|compound|END_ENTITY	mTORC1 activity as a determinant of cancer risk -- rationalizing the cancer-preventive effects of adiponectin , metformin , rapamycin , and low-protein vegan diets .
23199540	0	metformin	77,86	adiponectin	7,18	metformin	adiponectin	MESH:D008687	9370	Chemical	Gene	treatment|compound|START_ENTITY impact|nmod|treatment levels|dep|impact levels|compound|END_ENTITY	Plasma adiponectin levels in women with polycystic_ovary_syndrome : impact of metformin treatment in a case-control study .
23875783	0	metformin	78,87	adiponectin	8,19	metformin	adiponectin	MESH:D008687	9370	Chemical	Gene	treatment|compound|START_ENTITY outcome|nmod|treatment Role|nmod|outcome Role|nmod|END_ENTITY	Role of adiponectin and its receptor in prediction of reproductive outcome of metformin treatment in patients with polycystic_ovarian_syndrome .
25377599	0	metformin	14,23	adiponectin	37,48	metformin	adiponectin	MESH:D008687	9370	Chemical	Gene	treatment|compound|START_ENTITY treatment|nmod|levels levels|compound|END_ENTITY	The impact of metformin treatment on adiponectin and resistin levels in women with polycystic_ovary_syndrome : a prospective clinical study .
25199764	0	metformin	21,30	androgen_receptor	56,73	metformin	androgen receptor	MESH:D008687	367	Chemical	Gene	upregulated|nmod|START_ENTITY SMILE|acl|upregulated inhibits|nsubj|SMILE inhibits|dobj|function function|nmod|END_ENTITY	SMILE upregulated by metformin inhibits the function of androgen_receptor in prostate_cancer cells .
25237893	0	metformin	11,20	androgen_receptor	83,100	metformin	androgen receptor	MESH:D008687	367	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of metformin on endocrine , metabolic milieus and endometrial expression of androgen_receptor in patients with polycystic_ovary_syndrome .
24554512	0	metformin	11,20	c-reactive_protein	86,104	metformin	c-reactive protein	MESH:D008687	1401	Chemical	Gene	Effects|nmod|START_ENTITY Effects|acl|containing containing|nmod|concentrations concentrations|amod|END_ENTITY	Effects of metformin or an oral contraceptive containing cyproterone_acetate on serum c-reactive_protein , interleukin-6 and soluble vascular_cell_adhesion_molecule-1 concentrations in women with polycystic_ovary_syndrome .
22445233	0	metformin	78,87	chemerin	18,26	metformin	chemerin	MESH:D008687	297073(Tax:10116)	Chemical	Gene	stress|nmod|START_ENTITY stress|nsubj|Downregulation Downregulation|nmod|END_ENTITY	Downregulation of chemerin and alleviation of endoplasmic reticulum stress by metformin in adipose tissue of rats .
23129260	0	metformin	120,129	dipeptidyl_peptidase-4	82,104	metformin	dipeptidyl peptidase-4	MESH:D008687	1803	Chemical	Gene	inhibitor|nmod|START_ENTITY inhibitor|amod|END_ENTITY	Drug-induced generalized skin_eruption in a diabetes_mellitus patient receiving a dipeptidyl_peptidase-4 inhibitor plus metformin .
15464987	0	metformin	44,53	dipeptidyl_peptidase-IV	14,37	metformin	dipeptidyl peptidase-IV	MESH:D008687	25253(Tax:10116)	Chemical	Gene	treatments|compound|START_ENTITY serum|nmod|treatments serum|xcomp|END_ENTITY	Reduced serum dipeptidyl_peptidase-IV after metformin and pioglitazone treatments .
16945366	0	metformin	50,59	dipeptidyl_peptidase-IV	14,37	metformin	dipeptidyl peptidase-IV	MESH:D008687	13482(Tax:10090)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Inhibition of dipeptidyl_peptidase-IV activity by metformin enhances the antidiabetic effects of glucagon-like peptide-1 .
24050737	0	metformin	183,192	dipeptidyl_peptidase-IV	40,63	metformin	dipeptidyl peptidase-IV	MESH:D008687	1803	Chemical	Gene	diabetes|nmod|START_ENTITY diabetes|nsubj|study study|nmod|effects effects|nmod|inhibitor inhibitor|amod|END_ENTITY	A comparative study of the effects of a dipeptidyl_peptidase-IV inhibitor and sulfonylurea on glucose variability in patients with type 2 diabetes with inadequate glycemic control on metformin .
15842525	0	metformin	55,64	dipeptidyl_peptidase_IV	14,37	metformin	dipeptidyl peptidase IV	MESH:D008687	1803	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activity activity|amod|END_ENTITY	Inhibition of dipeptidyl_peptidase_IV activity by oral metformin in Type 2 diabetes .
27059001	0	metformin	62,71	dipeptidyl_peptidase_IV	25,48	metformin	dipeptidyl peptidase IV	MESH:D008687	1803	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|Effects Effects|nmod|addition addition|nmod|END_ENTITY	Effects of addition of a dipeptidyl_peptidase_IV inhibitor to metformin on sirolimus-induced diabetes_mellitus .
19106626	0	metformin	22,31	erbB-2	49,55	metformin	erbB-2	MESH:D008687	2064	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|overexpression overexpression|compound|END_ENTITY	The antidiabetic drug metformin suppresses HER2 -LRB- erbB-2 -RRB- oncoprotein overexpression via inhibition of the mTOR effector p70S6K1 in human breast_carcinoma cells .
25450818	0	metformin	23,32	fetuin-A	53,61	metformin	fetuin-A	MESH:D008687	197	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|concentrations concentrations|compound|END_ENTITY	Comparative effects of metformin and pioglitazone on fetuin-A and osteoprotegerin concentrations in patients with newly diagnosed diabetes : A randomized clinical trial .
9949668	0	metformin	11,20	fibrinogen	24,34	metformin	fibrinogen	MESH:D008687	2244	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|compound|END_ENTITY	Effects of metformin on fibrinogen levels in obese patients with type 2 diabetes .
15887627	0	metformin	11,20	glucagon-like_peptide-1	24,47	metformin	glucagon-like peptide-1	MESH:D008687	2641	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|amod|END_ENTITY	Effects of metformin on glucagon-like_peptide-1 levels in obese patients with and without Type 2 diabetes .
19289857	0	metformin	96,105	glucagon-like_peptide-1	33,56	metformin	glucagon-like peptide-1	MESH:D008687	2641	Chemical	Gene	combination|nmod|START_ENTITY liraglutide|nmod|combination liraglutide|nsubj|Efficacy Efficacy|nmod|analog analog|amod|END_ENTITY	Efficacy and safety of the human glucagon-like_peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes -LRB- LEAD-4 Met + TZD -RRB- .
20152998	0	metformin	12,21	glucagon-like_peptide-1	35,58	metformin	glucagon-like peptide-1	MESH:D008687	2641	Chemical	Gene	START_ENTITY|nmod|results results|amod|END_ENTITY	Addition of metformin to exogenous glucagon-like_peptide-1 results in increased serum glucagon-like_peptide-1 concentrations and greater glucose lowering in type_2_diabetes_mellitus .
20152998	0	metformin	12,21	glucagon-like_peptide-1	86,109	metformin	glucagon-like peptide-1	MESH:D008687	2641	Chemical	Gene	concentrations|amod|START_ENTITY concentrations|amod|END_ENTITY	Addition of metformin to exogenous glucagon-like_peptide-1 results in increased serum glucagon-like_peptide-1 concentrations and greater glucose lowering in type_2_diabetes_mellitus .
22471248	0	metformin	123,132	glucagon-like_peptide-1	22,45	metformin	glucagon-like peptide-1	MESH:D008687	2641	Chemical	Gene	efficacy|acl|START_ENTITY efficacy|nmod|agonists agonists|amod|END_ENTITY	Glycaemic efficacy of glucagon-like_peptide-1 receptor agonists and dipeptidyl_peptidase-4 inhibitors as add-on therapy to metformin in subjects with type 2 diabetes-a review and meta analysis .
24251641	0	metformin	109,118	glucagon-like_peptide-1	65,88	metformin	glucagon-like peptide-1	MESH:D008687	2641	Chemical	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	Dose response of continuous subcutaneous infusion of recombinant glucagon-like_peptide-1 in combination with metformin and sulphonylurea over 12 weeks in patients with type_2_diabetes_mellitus .
24362783	0	metformin	107,116	glucagon-like_peptide-1	160,183	metformin	glucagon-like peptide-1	MESH:D008687	2641	Chemical	Gene	agents|dep|START_ENTITY agents|nmod|analogs analogs|amod|END_ENTITY	-LSB- Effects of anti-diabetic therapy on overweight/obesity and dyslipidemia : traditional hypoglycemic agents -LRB- metformin , sulfonylureas , thiazolidinediones -RRB- versus glucagon-like_peptide-1 analogs and dipeptidyl_peptidase-4 inhibitors -RSB- .
24524806	0	metformin	192,201	glucagon-like_peptide-1	24,47	metformin	glucagon-like peptide-1	MESH:D008687	2641	Chemical	Gene	controlled|nmod|START_ENTITY type_2_diabetes_mellitus|acl|controlled lixisenatide|nmod|type_2_diabetes_mellitus lixisenatide|nsubj|Pharmacodynamics Pharmacodynamics|nmod|agonist agonist|amod|END_ENTITY	Pharmacodynamics of the glucagon-like_peptide-1 receptor agonist lixisenatide in Japanese and Caucasian patients with type_2_diabetes_mellitus poorly controlled on sulphonylureas with/without metformin .
22486277	0	metformin	34,43	glucagon-like_peptide_1	80,103	metformin	glucagon-like peptide 1	MESH:D008687	2641	Chemical	Gene	treatment|nmod|START_ENTITY treatment|amod|END_ENTITY	Effects of chronic treatment with metformin on dipeptidyl_peptidase-4 activity , glucagon-like_peptide_1 and ghrelin in obese patients with Type_2_diabetes_mellitus .
16275246	0	metformin	10,19	growth_hormone	27,41	metformin	growth hormone	MESH:D008687	2688	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|response response|amod|END_ENTITY	Effect of metformin on the growth_hormone response to growth_hormone-releasing hormone in obese women with polycystic_ovary_syndrome .
10230643	0	metformin	62,71	insulin	29,36	metformin	insulin	MESH:D008687	3630	Chemical	Gene	therapy|nmod|START_ENTITY therapy|compound|END_ENTITY	Causes of weight_gain during insulin therapy with and without metformin in patients with Type_II_diabetes mellitus .
10443322	0	metformin	59,68	insulin	72,79	metformin	insulin	MESH:D008687	3630	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	Membrane physiology as a basis for the cellular effects of metformin in insulin resistance and diabetes .
10576521	0	metformin	21,30	insulin	39,46	metformin	insulin	MESH:D008687	3630	Chemical	Gene	START_ENTITY|nmod|parameters parameters|compound|END_ENTITY	Clinical efficacy of metformin against insulin resistance parameters : sinking the iceberg .
11242605	0	metformin	112,121	insulin	13,20	metformin	insulin	MESH:D008687	3630	Chemical	Gene	combination|nmod|START_ENTITY use|nmod|combination avoided|nmod|use avoided|nsubjpass|therapy therapy|compound|END_ENTITY	How long can insulin therapy be avoided in the patient with type_2_diabetes_mellitus by use of a combination of metformin and a sulfonylurea ?
11789058	0	metformin	36,45	insulin	82,89	metformin	insulin	MESH:D008687	3630	Chemical	Gene	treatment|nmod|START_ENTITY Effect|nmod|treatment Effect|nmod|resistance resistance|compound|END_ENTITY	-LSB- Effect of long-term treatment with metformin on steroid levels and parameters of insulin resistance in women with polycystic_ovary_syndrome -RSB- .
12351462	0	metformin	19,28	insulin	61,68	metformin	insulin	MESH:D008687	3630	Chemical	Gene	Repaglinide|nmod|START_ENTITY Repaglinide|nmod|END_ENTITY	Repaglinide versus metformin in combination with bedtime NPH insulin in patients with type 2 diabetes established on insulin/metformin combination therapy .
12365468	0	metformin	19,28	insulin	70,77	metformin	insulin	MESH:D008687	3630	Chemical	Gene	Discontinuation|nmod|START_ENTITY treated|nsubj|Discontinuation treated|nmod|END_ENTITY	Discontinuation of metformin in type 2 diabetes patients treated with insulin .
12453953	0	metformin	16,25	insulin	65,72	metformin	insulin	MESH:D008687	3630	Chemical	Gene	therapy|compound|START_ENTITY benefits|nmod|therapy subcutaneous|nsubj|benefits subcutaneous|dobj|treatment treatment|compound|END_ENTITY	The benefits of metformin therapy during continuous subcutaneous insulin infusion treatment of type 1 diabetic patients .
12746632	0	metformin	10,19	insulin	23,30	metformin	insulin	MESH:D008687	3630	Chemical	Gene	START_ENTITY|nmod|sensitivity sensitivity|compound|END_ENTITY	Effect of metformin on insulin sensitivity and insulin secretion in female obese patients with normal glucose tolerance .
14502098	0	metformin	33,42	insulin	9,16	metformin	insulin	MESH:D008687	3630	Chemical	Gene	resistance|nmod|START_ENTITY resistance|compound|END_ENTITY	Reducing insulin resistance with metformin : the evidence today .
14617222	0	metformin	25,34	insulin	105,112	metformin	insulin	MESH:D008687	3630	Chemical	Gene	Comparison|nmod|START_ENTITY Comparison|acl|mealtime mealtime|dobj|therapy therapy|nmod|therapy therapy|compound|END_ENTITY	Comparison of additional metformin or NPH insulin to mealtime insulin lispro therapy with mealtime human insulin therapy in secondary OAD failure .
14617222	0	metformin	25,34	insulin	62,69	metformin	insulin	MESH:D008687	3630	Chemical	Gene	Comparison|nmod|START_ENTITY Comparison|acl|mealtime mealtime|dobj|therapy therapy|compound|END_ENTITY	Comparison of additional metformin or NPH insulin to mealtime insulin lispro therapy with mealtime human insulin therapy in secondary OAD failure .
15063963	0	metformin	15,24	insulin	28,35	metformin	insulin	MESH:D008687	3630	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|resistance resistance|compound|END_ENTITY	The effects of metformin on insulin resistance , clomiphene-induced ovulation and pregnancy rates in women with polycystic_ovary_syndrome .
15106708	0	metformin	47,56	insulin	14,21	metformin	insulin	MESH:D008687	3630	Chemical	Gene	Assessment|nmod|START_ENTITY Assessment|nmod|resistance resistance|compound|END_ENTITY	Assessment of insulin resistance and effect of metformin in nonalcoholic_steatohepatitis -- a preliminary report .
15482765	0	metformin	11,20	insulin	137,144	metformin	insulin	MESH:D008687	3630	Chemical	Gene	Effects|nmod|START_ENTITY nonobese|nsubj|Effects nonobese|nmod|indices indices|nmod|sensitivity sensitivity|compound|END_ENTITY	Effects of metformin and rosiglitazone , alone and in combination , in nonobese women with polycystic_ovary_syndrome and normal indices of insulin sensitivity .
15842521	0	metformin	11,20	insulin	35,42	metformin	insulin	MESH:D008687	3630	Chemical	Gene	START_ENTITY|advcl|starting starting|dobj|END_ENTITY	Continuing metformin when starting insulin in patients with Type 2 diabetes : a double-blind randomized placebo-controlled trial .
15975107	0	metformin	5,14	insulin	97,104	metformin	insulin	MESH:D008687	3630	Chemical	Gene	decrease|nsubj|START_ENTITY decrease|nmod|Type Type|acl|treated treated|nmod|END_ENTITY	Does metformin decrease blood pressure in patients with Type 2 diabetes intensively treated with insulin ?
16091082	0	metformin	30,39	insulin	43,50	metformin	insulin	MESH:D008687	3630	Chemical	Gene	addition|nmod|START_ENTITY Usefulness|nmod|addition Usefulness|nmod|END_ENTITY	Usefulness of the addition of metformin to insulin in pediatric patients with type_1_diabetes_mellitus .
16219011	0	metformin	52,61	insulin	9,16	metformin	insulin	MESH:D008687	3630	Chemical	Gene	diabetes|nmod|START_ENTITY resistance|nmod|diabetes resistance|compound|END_ENTITY	Treating insulin resistance in type 2 diabetes with metformin and thiazolidinediones .
16732009	0	metformin	125,134	insulin	102,109	metformin	insulin	MESH:D008687	3630	Chemical	Gene	study|nmod|START_ENTITY study|acl|compare compare|dobj|profile profile|nmod|END_ENTITY	An open , randomized , parallel-group study to compare the efficacy and safety profile of inhaled human insulin -LRB- Exubera -RRB- with metformin as adjunctive therapy in patients with type 2 diabetes poorly controlled on a sulfonylurea .
16764619	0	metformin	11,20	insulin	24,31	metformin	insulin	MESH:D008687	3630	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|rates rates|compound|END_ENTITY	Effects of metformin on insulin resistance , androgen concentration , ovulation and pregnancy rates in women with polycystic_ovary_syndrome following laparoscopic ovarian_drilling .
16784971	0	metformin	97,106	insulin	15,22	metformin	insulin	MESH:D008687	397415(Tax:9823)	Chemical	Gene	model|amod|START_ENTITY effects|nmod|model Association|dep|effects Association|nmod|resistance resistance|compound|END_ENTITY	Association of insulin resistance with hyperglycemia in streptozotocin-diabetic pigs : effects of metformin at isoenergetic feeding in a type 2-like diabetic pig model .
16873786	0	metformin	215,224	insulin	102,109	metformin	insulin	MESH:D008687	3630	Chemical	Gene	controlled|nmod|START_ENTITY controlled|nsubj|study study|acl|compare compare|dobj|profile profile|nmod|END_ENTITY	An open , randomized , parallel-group study to compare the efficacy and safety profile of inhaled human insulin -LRB- Exubera -RRB- with glibenclamide as adjunctive therapy in patients with type 2 diabetes poorly controlled on metformin .
16916482	0	metformin	7,16	insulin	113,120	metformin	insulin	MESH:D008687	3630	Chemical	Gene	Use|nmod|START_ENTITY Use|nmod|resistance resistance|compound|END_ENTITY	Use of metformin for ovulation induction in women who have polycystic_ovary_syndrome with or without evidence of insulin resistance .
17224152	0	metformin	17,26	insulin	58,65	metformin	insulin	MESH:D008687	3630	Chemical	Gene	therapy|compound|START_ENTITY effects|nmod|therapy include|nsubj|effects include|dobj|improvement improvement|nmod|resistance resistance|compound|END_ENTITY	Acute effects of metformin therapy include improvement of insulin resistance and ovarian morphology .
17309383	0	metformin	56,65	insulin	90,97	metformin	insulin	MESH:D008687	3630	Chemical	Gene	combination|nmod|START_ENTITY Murill|nmod|combination improves|nsubj|Murill improves|dobj|resistance resistance|compound|END_ENTITY	The mushroom Agaricus Blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes : a randomized , double-blinded , and placebo-controlled clinical trial .
17403121	0	metformin	102,111	insulin	134,141	metformin	insulin	MESH:D008687	3630	Chemical	Gene	therapy|compound|START_ENTITY rosiglitazone|dobj|therapy rosiglitazone|advcl|starting starting|dobj|therapy therapy|compound|END_ENTITY	A double-blind randomized study comparing the effects of continuing or not continuing rosiglitazone + metformin therapy when starting insulin therapy in people with Type 2 diabetes .
17445933	0	metformin	78,87	insulin	25,32	metformin	insulin	MESH:D008687	3630	Chemical	Gene	comparison|nmod|START_ENTITY comparison|nmod|aspart aspart|compound|END_ENTITY	A comparison of mealtime insulin aspart and human insulin in combination with metformin in type 2 diabetes patients .
17941873	0	metformin	52,61	insulin	21,28	metformin	insulin	MESH:D008687	3630	Chemical	Gene	aspart|nmod|START_ENTITY aspart|nsubj|Addition Addition|nmod|END_ENTITY	Addition of biphasic insulin aspart 30 to optimized metformin and pioglitazone treatment of type_2_diabetes_mellitus : The ACTION Study -LRB- Achieving Control Through Insulin plus Oral ageNts -RRB- .
18158075	0	metformin	137,146	insulin	52,59	metformin	insulin	MESH:D008687	3630	Chemical	Gene	uncontrolled|nmod|START_ENTITY uncontrolled|dep|Tolerability Tolerability|nmod|glargine glargine|compound|END_ENTITY	Tolerability and efficacy of exenatide and titrated insulin glargine in adult patients with type 2 diabetes previously uncontrolled with metformin or a sulfonylurea : a multinational , randomized , open-label , two-period , crossover noninferiority trial .
18166815	0	metformin	10,19	insulin	40,47	metformin	insulin	MESH:D008687	3630	Chemical	Gene	Impact|nmod|START_ENTITY Impact|nmod|END_ENTITY	Impact of metformin versus the prandial insulin secretagogue , repaglinide , on fasting and postprandial glucose and lipid responses in non-obese patients with type 2 diabetes .
1834486	0	metformin	30,39	insulin	4,11	metformin	insulin	MESH:D008687	3630	Chemical	Gene	effect|nmod|START_ENTITY sparing|dobj|effect END_ENTITY|acl|sparing	The insulin sparing effect of metformin in insulin-treated diabetic patients .
18482898	0	metformin	14,23	insulin	115,122	metformin	insulin	MESH:D008687	100060077(Tax:9796)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|measurements measurements|nmod|sensitivity sensitivity|nmod|horses horses|nmod|resistance resistance|compound|END_ENTITY	The effect of metformin on measurements of insulin sensitivity and beta cell response in 18 horses and ponies with insulin resistance .
18482898	0	metformin	14,23	insulin	43,50	metformin	insulin	MESH:D008687	100060077(Tax:9796)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|measurements measurements|nmod|sensitivity sensitivity|compound|END_ENTITY	The effect of metformin on measurements of insulin sensitivity and beta cell response in 18 horses and ponies with insulin resistance .
18492523	0	metformin	12,21	insulin	78,85	metformin	insulin	MESH:D008687	3630	Chemical	Gene	Addition|nmod|START_ENTITY Addition|nmod|adolescents adolescents|nmod|resistance resistance|compound|END_ENTITY	Addition of metformin to a lifestyle modification program in adolescents with insulin resistance .
18547343	0	metformin	10,19	insulin	65,72	metformin	insulin	MESH:D008687	3630	Chemical	Gene	treatment|compound|START_ENTITY treatment|nmod|resistance resistance|compound|END_ENTITY	Effect of metformin , orlistat and pioglitazone treatment on mean insulin resistance and its biological variability in polycystic_ovary_syndrome .
18555837	0	metformin	169,178	insulin	39,46	metformin	insulin	MESH:D008687	3630	Chemical	Gene	treated|nmod|START_ENTITY study|acl|treated study|nmod|resistance resistance|compound|END_ENTITY	An observational study of reduction of insulin resistance and prevention of development of type_2_diabetes_mellitus in women with polycystic_ovary_syndrome treated with metformin and diet .
1900072	0	metformin	49,58	insulin	9,16	metformin	insulin	MESH:D008687	3630	Chemical	Gene	hypertension|nmod|START_ENTITY resistance|nmod|hypertension resistance|compound|END_ENTITY	Treating insulin resistance in hypertension with metformin reduces both blood pressure and metabolic risk factors .
1936485	1	metformin	99,108	insulin	189,196	metformin	insulin	MESH:D008687	3630	Chemical	Gene	trial|nmod|START_ENTITY trial|acl|associated associated|nmod|resistance resistance|compound|END_ENTITY	A randomized trial of metformin versus placebo in the correction of the metabolic_abnormalities associated with insulin resistance .
19845037	0	metformin	37,46	insulin	13,20	metformin	insulin	MESH:D008687	3630	Chemical	Gene	resistance|nmod|START_ENTITY resistance|compound|END_ENTITY	Treatment of insulin resistance with metformin in na ve genotype 1 chronic hepatitis_C patients receiving peginterferon alfa-2a plus ribavirin .
20226444	0	metformin	11,20	insulin	47,54	metformin	insulin	MESH:D008687	3630	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	Effects of metformin and leuprolide_acetate on insulin resistance and testosterone levels in nondiabetic postmenopausal women : a randomized , placebo-controlled trial .
20687400	0	metformin	9,18	insulin	176,183	metformin	insulin	MESH:D008687	3630	Chemical	Gene	improves|nsubj|START_ENTITY improves|parataxis|related related|nmod|resistance resistance|compound|END_ENTITY	Low-dose metformin improves pregnancy rate in in vitro fertilization repeaters without polycystic_ovary_syndrome : prediction of effectiveness by multiple parameters related to insulin resistance .
21234175	0	metformin	10,19	insulin	48,55	metformin	insulin	MESH:D008687	3630	Chemical	Gene	therapy|compound|START_ENTITY Effect|nmod|therapy Effect|nmod|levels levels|compound|END_ENTITY	Effect of metformin therapy on 2-h post-glucose insulin levels in patients of polycystic_ovarian_syndrome .
21471135	0	metformin	96,105	insulin	60,67	metformin	insulin	MESH:D008687	3630	Chemical	Gene	secretagogues|nmod|START_ENTITY secretagogues|compound|END_ENTITY	Mortality and cardiovascular risk associated with different insulin secretagogues compared with metformin in type_2_diabetes , with or without a previous myocardial_infarction : a nationwide study .
21481127	0	metformin	47,56	insulin	21,28	metformin	insulin	MESH:D008687	3630	Chemical	Gene	added|xcomp|START_ENTITY glargine|acl|added glargine|compound|END_ENTITY	An analysis of early insulin glargine added to metformin with or without sulfonylurea : impact on glycaemic control and hypoglycaemia .
21672339	0	metformin	11,20	insulin	53,60	metformin	insulin	MESH:D008687	3630	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	Effects of metformin and rosiglitazone on peripheral insulin resistance and b-cell function in obesity : a double-blind , randomized , controlled study .
2191888	0	metformin	17,26	insulin	30,37	metformin	insulin	MESH:D008687	3630	Chemical	Gene	Improvement|nmod|START_ENTITY Improvement|nmod|internalization internalization|compound|END_ENTITY	Improvement with metformin in insulin internalization and processing in monocytes from NIDDM patients .
22016348	0	metformin	12,21	insulin	105,112	metformin	insulin	MESH:D008687	3630	Chemical	Gene	Addition|nmod|START_ENTITY Addition|acl|sildenafil sildenafil|nmod|resistance resistance|compound|END_ENTITY	Addition of metformin to sildenafil treatment for erectile_dysfunction in eugonadal nondiabetic men with insulin resistance .
22117989	0	metformin	25,34	insulin	55,62	metformin	insulin	MESH:D008687	3630	Chemical	Gene	therapy|nmod|START_ENTITY therapy|nmod|resistance resistance|compound|END_ENTITY	Combination therapy with metformin and fenofibrate for insulin resistance in obesity .
22517929	0	metformin	14,23	insulin	43,50	metformin	insulin	MESH:D008687	3630	Chemical	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|END_ENTITY	Comparison of metformin and insulin versus insulin alone for type 2 diabetes : systematic review of randomised clinical trials with meta-analyses and trial sequential analyses .
22570949	0	metformin	15,24	insulin	77,84	metformin	insulin	MESH:D008687	3630	Chemical	Gene	START_ENTITY|nmod|mediators mediators|nmod|resistance resistance|compound|END_ENTITY	The effects of metformin on inflammatory mediators in obese adolescents with insulin resistance : controlled randomized clinical trial .
22740509	0	metformin	14,23	insulin	27,34	metformin	insulin	MESH:D008687	3630	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|resistance resistance|compound|END_ENTITY	The effect of metformin on insulin resistance and exercise parameters in patients with heart_failure .
23020608	1	metformin	81,90	insulin	119,126	metformin	insulin	MESH:D008687	3630	Chemical	Gene	patients|compound|START_ENTITY characterizing|dobj|patients characterizing|advcl|needing needing|dobj|END_ENTITY	A randomized study characterizing metformin patients needing additional insulin .
23094143	0	metformin	11,20	insulin	62,69	metformin	insulin	MESH:D008687	3630	Chemical	Gene	START_ENTITY|nmod|regulation regulation|nmod|Fatty_acids Fatty_acids|nmod|resistance resistance|compound|END_ENTITY	Effects of metformin on the regulation of free Fatty_acids in insulin resistance : a double-blind , placebo-controlled study .
23110609	8	metformin	1855,1864	insulin	1819,1826	metformin	insulin	MESH:D008687	3630	Chemical	Gene	liraglutide|dobj|START_ENTITY addition|acl|liraglutide addition|nmod|detemir detemir|compound|END_ENTITY	The addition of insulin detemir to liraglutide plus metformin improved glycaemic control in insulin-naive patients with type 2 diabetes and inadequate glycaemic control , although a significantly greater reduction in bodyweight was seen in patients receiving liraglutide plus metformin than in those receiving add-on therapy with insulin detemir .
23110609	8	metformin	2078,2087	insulin	1819,1826	metformin	insulin	MESH:D008687	3630	Chemical	Gene	receiving|advmod|START_ENTITY receiving|advcl|receiving patients|acl|receiving seen|nmod|patients improved|advcl|seen improved|nsubj|addition addition|nmod|detemir detemir|compound|END_ENTITY	The addition of insulin detemir to liraglutide plus metformin improved glycaemic control in insulin-naive patients with type 2 diabetes and inadequate glycaemic control , although a significantly greater reduction in bodyweight was seen in patients receiving liraglutide plus metformin than in those receiving add-on therapy with insulin detemir .
23315599	0	metformin	4,13	insulin	57,64	metformin	insulin	MESH:D008687	3630	Chemical	Gene	acts|nsubj|START_ENTITY acts|dep|insights insights|nmod|secretion secretion|compound|END_ENTITY	How metformin acts in PCOS pregnant women : insights into insulin secretion and peripheral action at each trimester of gestation .
23421331	0	metformin	52,61	insulin	118,125	metformin	insulin	MESH:D008687	3630	Chemical	Gene	add-on|nmod|START_ENTITY insulin|nmod|add-on initiation|nmod|insulin initiation|dep|trial trial|acl|comparing comparing|dobj|detemir detemir|compound|END_ENTITY	Once-daily initiation of basal insulin as add-on to metformin : a 26-week , randomized , treat-to-target trial comparing insulin detemir with insulin glargine in patients with type_2_diabetes .
23421331	0	metformin	52,61	insulin	139,146	metformin	insulin	MESH:D008687	3630	Chemical	Gene	add-on|nmod|START_ENTITY insulin|nmod|add-on initiation|nmod|insulin initiation|dep|trial trial|acl|comparing comparing|nmod|glargine glargine|compound|END_ENTITY	Once-daily initiation of basal insulin as add-on to metformin : a 26-week , randomized , treat-to-target trial comparing insulin detemir with insulin glargine in patients with type_2_diabetes .
23421331	0	metformin	52,61	insulin	31,38	metformin	insulin	MESH:D008687	3630	Chemical	Gene	add-on|nmod|START_ENTITY END_ENTITY|nmod|add-on	Once-daily initiation of basal insulin as add-on to metformin : a 26-week , randomized , treat-to-target trial comparing insulin detemir with insulin glargine in patients with type_2_diabetes .
23640946	0	metformin	141,150	insulin	41,48	metformin	insulin	MESH:D008687	3630	Chemical	Gene	monotherapy|compound|START_ENTITY treated|nmod|monotherapy efficacy|acl|treated efficacy|nmod|glargine glargine|compound|END_ENTITY	Comparative efficacy of exenatide versus insulin glargine on glycemic control in type_2_diabetes_mellitus patients inadequately treated with metformin monotherapy .
23746555	0	metformin	109,118	insulin	131,138	metformin	insulin	MESH:D008687	3630	Chemical	Gene	START_ENTITY|acl|followed followed|nmod|detemir detemir|compound|END_ENTITY	One-year sustained glycemic control and weight reduction in type 2 diabetes after addition of liraglutide to metformin followed by insulin detemir according to HbA1c target .
24113668	0	metformin	72,81	insulin	41,48	metformin	insulin	MESH:D008687	3630	Chemical	Gene	Exenatide|advcl|START_ENTITY Exenatide|dobj|weekly weekly|nmod|END_ENTITY	Exenatide once weekly versus daily basal insulin as add-on treatment to metformin with or without a sulfonylurea : a retrospective pooled analysis in patients with poor glycemic control .
24259985	0	metformin	77,86	insulin	23,30	metformin	insulin	MESH:D008687	3630	Chemical	Gene	combination|nmod|START_ENTITY added|nmod|combination added|nsubj|Efficacy Efficacy|nmod|glargine glargine|compound|END_ENTITY	Efficacy and safety of insulin glargine added to a fixed-dose combination of metformin and a dipeptidyl_peptidase-4 inhibitor : results of the GOLD observational study .
24595965	0	metformin	127,136	insulin	19,26	metformin	insulin	MESH:D008687	3630	Chemical	Gene	study|nmod|START_ENTITY data|nmod|study levels|dep|data levels|compound|END_ENTITY	Maternal and fetal insulin levels at birth in women with polycystic_ovary_syndrome : data from a randomized controlled study on metformin .
24876433	0	metformin	36,45	insulin	14,21	metformin	insulin	MESH:D008687	3630	Chemical	Gene	users|compound|START_ENTITY initiation|nmod|users initiation|compound|END_ENTITY	Predictors of insulin initiation in metformin and sulfonylurea users in primary care practices : the role of kidney function .
25131985	0	metformin	15,24	insulin	40,47	metformin	insulin	MESH:D008687	3630	Chemical	Gene	START_ENTITY|nmod|addition addition|nmod|END_ENTITY	Current use of metformin in addition to insulin in pediatric patients with type_1_diabetes_mellitus : an analysis based on a large diabetes registry in Germany and Austria .
25246913	0	metformin	94,103	insulin	44,51	metformin	insulin	MESH:D008687	3630	Chemical	Gene	therapy|compound|START_ENTITY effects|nmod|therapy effects|nmod|calcitriol calcitriol|nmod|improvement improvement|nmod|resistance resistance|compound|END_ENTITY	The effects of calcitriol on improvement of insulin resistance , ovulation and comparison with metformin therapy in PCOS patients : a randomized placebo - controlled clinical trial .
25662675	0	metformin	144,153	insulin	79,86	metformin	insulin	MESH:D008687	3630	Chemical	Gene	treated|nmod|START_ENTITY type_2_diabetes|acl|treated patients|nmod|type_2_diabetes resistance|nmod|patients resistance|compound|END_ENTITY	The variant organic_cation_transporter_2 -LRB- OCT2 -RRB- - T201M contribute to changes in insulin resistance in patients with type_2_diabetes treated with metformin .
26990378	0	metformin	100,109	insulin	21,28	metformin	insulin	MESH:D008687	3630	Chemical	Gene	controlled|nmod|START_ENTITY effect|acl|controlled effect|acl|adding adding|dobj|degludec degludec|compound|END_ENTITY	The effect of adding insulin degludec in patients with type 2 diabetes inadequately controlled with metformin and liraglutide : a double-blind randomized controlled trial -LRB- BEGIN : ADD TO GLP-1 Study -RRB- .
3745404	0	metformin	23,32	insulin	34,41	metformin	insulin	MESH:D008687	3630	Chemical	Gene	action|nmod|START_ENTITY Mechanism|nmod|action Mechanism|dep|receptor receptor|compound|END_ENTITY	Mechanism of action of metformin : insulin receptor and postreceptor effects in vitro and in vivo .
3908277	0	metformin	81,90	insulin	15,22	metformin	insulin	MESH:D008687	3630	Chemical	Gene	effect|nmod|START_ENTITY part|nmod|effect part|nsubj|Improvement Improvement|nmod|action action|compound|END_ENTITY	Improvement of insulin action is an important part of the antidiabetic effect of metformin .
4995366	0	metformin	80,89	insulin	94,101	metformin	insulin	MESH:D008687	3630	Chemical	Gene	phenformin|appos|START_ENTITY demonstration|dep|phenformin demonstration|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Experimental demonstration of the simulating action of biguanides -LRB- phenformin , metformin -RRB- on insulin secretion -RSB- .
6390140	0	metformin	11,20	insulin	48,55	metformin	insulin	MESH:D008687	3630	Chemical	Gene	START_ENTITY|nmod|action action|nmod|END_ENTITY	-LSB- Effect of metformin on the metabolic action of insulin in human adipose tissue `` in vitro '' and `` in vivo '' -RSB- .
6397366	0	metformin	13,22	insulin	46,53	metformin	insulin	MESH:D008687	3630	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|effect effect|nmod|END_ENTITY	Influence of metformin on metabolic effect of insulin in human adipose tissue in vitro .
7704288	0	metformin	14,23	insulin	121,128	metformin	insulin	MESH:D008687	3630	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of metformin and insulin on sympathetic nerve activity , norepinephrine spillover and blood pressure in obese , insulin resistant , normoglycemic , hypertensive men .
8126125	0	metformin	49,58	insulin	38,45	metformin	insulin	MESH:D008687	3630	Chemical	Gene	circulating|nmod|START_ENTITY circulating|dobj|END_ENTITY	Effects of a reduction in circulating insulin by metformin on serum dehydroepiandrosterone_sulfate in nondiabetic men .
8462390	0	metformin	11,20	insulin	24,31	metformin	insulin	MESH:D008687	3630	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	Effects of metformin on insulin resistance , risk factors for cardiovascular_disease , and plasminogen activator inhibitor in NIDDM subjects .
8529763	0	metformin	69,78	insulin	11,18	metformin	insulin	MESH:D008687	3630	Chemical	Gene	treatment|compound|START_ENTITY associated|nmod|treatment activity|acl|associated tyrosine|dobj|activity tyrosine|nsubj|Changes Changes|nmod|receptor receptor|compound|END_ENTITY	Changes in insulin receptor tyrosine kinase activity associated with metformin treatment of type 2 diabetes .
8582131	0	metformin	24,33	insulin	43,50	metformin	insulin	MESH:D008687	3630	Chemical	Gene	administration|nmod|START_ENTITY improves|nsubj|administration improves|dobj|sensitivity sensitivity|compound|END_ENTITY	Short administration of metformin improves insulin sensitivity in android_obese subjects with impaired_glucose_tolerance .
8636369	0	metformin	38,47	insulin	15,22	metformin	insulin	MESH:D008687	3630	Chemical	Gene	treatment|compound|START_ENTITY sensitivity|nmod|treatment sensitivity|compound|END_ENTITY	Improvement of insulin sensitivity by metformin treatment does not lower blood pressure of nonobese insulin-resistant hypertensive patients with normal glucose tolerance .
9539300	0	metformin	23,32	insulin	36,43	metformin	insulin	MESH:D008687	3630	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|resistance resistance|compound|END_ENTITY	Therapeutic effects of metformin on insulin resistance and hyperandrogenism in polycystic_ovary_syndrome .
9597374	0	metformin	69,78	insulin	29,36	metformin	insulin	MESH:D008687	3630	Chemical	Gene	Evidence|nmod|START_ENTITY Evidence|nmod|END_ENTITY	Evidence for dissociation of insulin - and weight-reducing effects of metformin in non-diabetic male patients with coronary_heart_disease .
9868971	0	metformin	7,16	insulin	24,31	metformin	insulin	MESH:D008687	3630	Chemical	Gene	Adding|dobj|START_ENTITY Adding|nmod|increase increase|compound|END_ENTITY	Adding metformin versus insulin dose increase in insulin-treated but poorly controlled Type_2_diabetes_mellitus : an open-label randomized trial .
17953367	0	metformin	15,24	insulin_receptor	28,44	metformin	insulin receptor	MESH:D008687	3643	Chemical	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	-LSB- The effect of metformin on insulin_receptor protein tyrosine kinase activity of HIT-T15 cell exposed to high concentration glucose and free fatty_acid -RSB- .
25778376	0	metformin	59,68	insulin_receptor	11,27	metformin	insulin receptor	MESH:D008687	3643	Chemical	Gene	administration|compound|START_ENTITY underlie|dobj|administration signaling|ccomp|underlie END_ENTITY|acl|signaling	Changes in insulin_receptor signaling underlie neoadjuvant metformin administration in breast_cancer : a prospective window of opportunity neoadjuvant study .
19188739	0	metformin	126,135	interleukin-6	16,29	metformin	interleukin-6	MESH:D008687	3569	Chemical	Gene	therapy|compound|START_ENTITY effects|nmod|therapy do|dobj|effects vary|advcl|do vary|nsubj|Determinants Determinants|nmod|END_ENTITY	Determinants of interleukin-6 and C-reactive_protein vary in polycystic_ovary_syndrome , as do effects of short - and long-term metformin therapy .
20730705	0	metformin	51,60	interleukin-6	131,144	metformin	interleukin-6	MESH:D008687	3569	Chemical	Gene	polycystic_ovary_syndrome|nmod|START_ENTITY Treatment|nmod|polycystic_ovary_syndrome ameliorates|nsubj|Treatment ameliorates|nmod|decrease decrease|nmod|concentrations concentrations|amod|END_ENTITY	Treatment of polycystic_ovary_syndrome -LRB- PCOS -RRB- with metformin ameliorates insulin resistance in parallel with the decrease of serum interleukin-6 concentrations .
25096410	0	metformin	10,19	interleukin-6	29,42	metformin	interleukin-6	MESH:D008687	3569	Chemical	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	Effect of metformin on serum interleukin-6 levels in polycystic_ovary_syndrome : a systematic review .
11068959	0	metformin	11,20	leptin	37,43	metformin	leptin	MESH:D008687	25608(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of metformin and vanadium on leptin secretion from cultured rat adipocytes .
11912566	0	metformin	26,35	leptin	52,58	metformin	leptin	MESH:D008687	3952	Chemical	Gene	treatment|nmod|START_ENTITY decreases|nsubj|treatment decreases|dobj|concentration concentration|compound|END_ENTITY	Short-term treatment with metformin decreases serum leptin concentration without affecting body weight and body fat content in normal-weight healthy men .
9661644	0	metformin	45,54	leptin	16,22	metformin	leptin	MESH:D008687	3952	Chemical	Gene	therapy|compound|START_ENTITY serum|nmod|therapy serum|dobj|concentrations concentrations|compound|END_ENTITY	Decreased serum leptin concentrations during metformin therapy in obese women with polycystic_ovary_syndrome .
21862237	0	metformin	109,118	mTORC1	0,6	metformin	mTORC1	MESH:D008687	382056(Tax:10090)	Chemical	Gene	rapamycin|dep|START_ENTITY effects|nmod|rapamycin rationalizing|dobj|effects risk|parataxis|rationalizing risk|nsubj|activity activity|amod|END_ENTITY	mTORC1 activity as a determinant of cancer risk -- rationalizing the cancer-preventive effects of adiponectin , metformin , rapamycin , and low-protein vegan diets .
25926238	0	metformin	46,55	mTORC1	12,18	metformin	mTORC1	MESH:D008687	382056(Tax:10090)	Chemical	Gene	treatment|compound|START_ENTITY unaffected|nmod|treatment unaffected|nsubj|END_ENTITY	Hyperactive mTORC1 signaling is unaffected by metformin treatment in aged skeletal muscle .
11720083	0	metformin	10,19	nitric_oxide_synthase	23,44	metformin	nitric oxide synthase	MESH:D008687	18125(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of metformin on nitric_oxide_synthase in genetically obese -LRB- ob/ob -RRB- mice .
23328000	0	metformin	23,32	omentin	53,60	metformin	omentin	MESH:D008687	55600	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|concentrations concentrations|compound|END_ENTITY	Comparative effects of metformin and pioglitazone on omentin and leptin concentrations in patients with newly diagnosed diabetes : a randomized clinical trial .
12130709	0	metformin	86,95	organic_cation_transporter_1	15,43	metformin	organic cation transporter 1	MESH:D008687	20517(Tax:10090)	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of organic_cation_transporter_1 in hepatic and intestinal distribution of metformin .
19483665	0	metformin	92,101	organic_cation_transporter_2	35,63	metformin	organic cation transporter 2	MESH:D008687	6582	Chemical	Gene	elimination|nmod|START_ENTITY END_ENTITY|nmod|elimination	Effect of genetic variation in the organic_cation_transporter_2 on the renal elimination of metformin .
24981592	0	metformin	115,124	organic_cation_transporter_2	38,66	metformin	organic cation transporter 2	MESH:D008687	29503(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of age-related decrease of renal organic_cation_transporter_2 in the effect of atenolol on renal excretion of metformin in rats .
23562376	0	metformin	12,21	organic_cation_transporter_3	61,89	metformin	organic cation transporter 3	MESH:D008687	29504(Tax:10116)	Chemical	Gene	Transfer|nmod|START_ENTITY mediated|nsubjpass|Transfer mediated|nmod|END_ENTITY	Transfer of metformin across the rat placenta is mediated by organic_cation_transporter_3 -LRB- OCT3/SLC22A3 -RRB- and multidrug_and_toxin_extrusion_1 -LRB- MATE1/SLC47A1 -RRB- protein .
26198758	0	metformin	10,19	osteoprotegerin	45,60	metformin	osteoprotegerin	MESH:D008687	4982	Chemical	Gene	treatment|compound|START_ENTITY treatment|acl|circulating circulating|dobj|END_ENTITY	Effect of metformin treatment on circulating osteoprotegerin in patients with nonalcoholic_fatty_liver_disease .
26198758	0	metformin	10,19	osteoprotegerin	45,60	metformin	osteoprotegerin	MESH:D008687	4982	Chemical	Gene	treatment|compound|START_ENTITY treatment|acl|circulating circulating|dobj|END_ENTITY	Effect of metformin treatment on circulating osteoprotegerin in patients with nonalcoholic_fatty_liver_disease .
22982676	15	metformin	2390,2399	p38	2442,2445	metformin	p38	MESH:D008687	26416(Tax:10090)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|nmod|END_ENTITY	However , metformin significantly decreases the expression of p38 , indicating that metformin mediated lipoprotection involves reduced activity of the p38 signaling pathway .
22982676	15	metformin	2463,2472	p38	2442,2445	metformin	p38	MESH:D008687	26416(Tax:10090)	Chemical	Gene	lipoprotection|amod|START_ENTITY involves|nsubj|lipoprotection indicating|ccomp|involves decreases|advcl|indicating decreases|dobj|expression expression|nmod|END_ENTITY	However , metformin significantly decreases the expression of p38 , indicating that metformin mediated lipoprotection involves reduced activity of the p38 signaling pathway .
24138903	0	metformin	71,80	p38	14,17	metformin	p38	MESH:D008687	1432	Chemical	Gene	expression|nmod|START_ENTITY MutS_homologue-2|acl|expression MutS_homologue-2|amod|END_ENTITY	Inhibition of p38 MAPK-dependent MutS_homologue-2 -LRB- MSH2 -RRB- expression by metformin enhances gefitinib-induced cytotoxicity in human squamous_lung_cancer cells .
12485530	0	metformin	11,20	phosphoenolpyruvate_carboxykinase	43,76	metformin	phosphoenolpyruvate carboxykinase	MESH:D008687	362282(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Effect of metformin on gene expression of phosphoenolpyruvate_carboxykinase -RSB- .
12622936	0	metformin	67,76	phosphoenolpyruvate_carboxykinase	14,47	metformin	phosphoenolpyruvate carboxykinase	MESH:D008687	362282(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Inhibition of phosphoenolpyruvate_carboxykinase gene expression by metformin in cultured hepatocytes .
8862952	0	metformin	10,19	proinsulin	30,40	metformin	proinsulin	MESH:D008687	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of metformin on intact proinsulin and des 31,32 proinsulin concentrations in subjects with non-insulin-dependent -LRB- type 2 -RRB- diabetes_mellitus .
25239203	0	metformin	25,34	prolactin	55,64	metformin	prolactin	MESH:D008687	5617	Chemical	Gene	treatment|compound|START_ENTITY treatment|nmod|levels levels|compound|END_ENTITY	The effect of short-term metformin treatment on plasma prolactin levels in bromocriptine-treated patients with hyperprolactinaemia and impaired_glucose_tolerance : a pilot study .
26858210	0	metformin	14,23	prolactin	27,36	metformin	prolactin	MESH:D008687	5617	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|levels levels|compound|END_ENTITY	The effect of metformin on prolactin levels in patients with drug-induced_hyperprolactinemia .
12413946	0	metformin	10,19	resistin	38,46	metformin	resistin	MESH:D008687	57264(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of metformin on adipose tissue resistin expression in db/db mice .
16367888	0	metformin	11,20	resistin	63,71	metformin	resistin	MESH:D008687	56729	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of metformin and oleic_acid on adipocyte expression of resistin .
23677182	0	metformin	11,20	tumor_necrosis_factor-a	42,65	metformin	tumor necrosis factor-a	MESH:D008687	7124	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of metformin on the expression of tumor_necrosis_factor-a , Toll_like_receptors_2 / 4 and C_reactive_protein in obese type-2 diabetic patients -RSB- .
24554512	0	metformin	11,20	vascular_cell_adhesion_molecule-1	132,165	metformin	vascular cell adhesion molecule-1	MESH:D008687	7412	Chemical	Gene	Effects|nmod|START_ENTITY Effects|acl|containing containing|nmod|concentrations concentrations|amod|END_ENTITY	Effects of metformin or an oral contraceptive containing cyproterone_acetate on serum c-reactive_protein , interleukin-6 and soluble vascular_cell_adhesion_molecule-1 concentrations in women with polycystic_ovary_syndrome .
25179820	0	metformin	23,32	vascular_endothelial_growth_factor	42,76	metformin	vascular endothelial growth factor	MESH:D008687	7422	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	The anti-diabetic drug metformin inhibits vascular_endothelial_growth_factor expression via the mammalian target of rapamycin complex 1/hypoxia-inducible _ factor-1a signaling pathway in ELT-3 cells .
25785990	0	metformin	26,35	vascular_endothelial_growth_factor	110,144	metformin	vascular endothelial growth factor	MESH:D008687	7422	Chemical	Gene	effect|nmod|START_ENTITY mediated|nsubjpass|effect mediated|advcl|reducing reducing|xcomp|flk-1 flk-1|nsubj|levels levels|nmod|receptor receptor|compound|END_ENTITY	Anti-angiogenic effect of metformin in mouse oxygen-induced retinopathy is mediated by reducing levels of the vascular_endothelial_growth_factor receptor flk-1 .
18375437	12	metformin	1601,1610	vaspin	1694,1700	metformin	vaspin	MESH:D008687	145264	Chemical	Gene	therapy|compound|START_ENTITY predictive|nsubj|therapy predictive|nmod|changes changes|nmod|levels levels|compound|END_ENTITY	Furthermore , multivariate regression analysis revealed that following metformin therapy , changes in circulating glucose levels were predictive of changes in serum vaspin levels -LRB- P = 0.014 -RRB- .
21325745	0	metformin	45,54	vaspin	64,70	metformin	vaspin	MESH:D008687	145264	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|levels levels|compound|END_ENTITY	The effect of weight_loss and treatment with metformin on serum vaspin levels in women with polycystic_ovary_syndrome .
21802961	0	metformin	122,131	vaspin	21,27	metformin	vaspin	MESH:D008687	145264	Chemical	Gene	control|nmod|START_ENTITY patients|nmod|control therapy|nmod|patients decreased|nmod|therapy decreased|nsubjpass|Elevated Elevated|acl|circulating circulating|dobj|levels levels|compound|END_ENTITY	Elevated circulating vaspin levels were decreased by rosiglitazone therapy in T2DM patients with poor glycemic control on metformin alone .
19111298	0	metformin	10,19	visfatin	29,37	metformin	visfatin	MESH:D008687	10135	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|compound|END_ENTITY	Effect of metformin on serum visfatin levels in patients with polycystic_ovary_syndrome .
24728163	0	metformin	10,19	visfatin	55,63	metformin	visfatin	MESH:D008687	297508(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY Impact|nmod|treatment exercise|nsubj|Impact exercise|nmod|levels levels|compound|END_ENTITY	Impact of metformin treatment and swimming exercise on visfatin levels in high-fat-induced obesity rats .
11476459	0	methacholine	68,80	IgE	97,100	methacholine	IgE	MESH:D016210	3497	Chemical	Gene	START_ENTITY|dobj|level level|compound|END_ENTITY	Age-dependent relationship between bronchial_hyperresponsiveness to methacholine and total serum IgE level in asthmatic children .
3277638	0	methacholine	81,93	cytochrome_P-450	24,40	methacholine	cytochrome P-450	MESH:D016210	100379244(Tax:10141)	Chemical	Gene	involvement|acl|START_ENTITY involvement|nmod|END_ENTITY	Possible involvement of cytochrome_P-450 in the epithelium-modulated response to methacholine in guinea_pig trachea .
21392098	0	methacholine	100,112	endothelial_nitric_oxide_synthase	127,160	methacholine	endothelial nitric oxide synthase	MESH:D016210	18127(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|compound|END_ENTITY	The peroxisome_proliferator-activated_receptor_a agonist fenofibrate decreases airway reactivity to methacholine and increases endothelial_nitric_oxide_synthase phosphorylation in mouse lung .
11939710	0	methacrylonitrile	10,27	CYP2E1	53,59	methacrylonitrile	CYP2E1	MESH:C008385	25086(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|appos|END_ENTITY	Effect of methacrylonitrile on cytochrome_P-450_2E1 -LRB- CYP2E1 -RRB- expression in male F344 rats .
11939710	0	methacrylonitrile	10,27	cytochrome_P-450_2E1	31,51	methacrylonitrile	cytochrome P-450 2E1	MESH:C008385	25086(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of methacrylonitrile on cytochrome_P-450_2E1 -LRB- CYP2E1 -RRB- expression in male F344 rats .
6861662	0	methadone	60,69	CD-1	87,91	methadone	CD-1	MESH:D008691	111334(Tax:10090)	Chemical	Gene	mice|amod|START_ENTITY mice|compound|END_ENTITY	Developmental_toxic_effect after subcutaneous injections of methadone in Charles River CD-1 mice .
18292673	0	methadone	40,49	CYP2B6	8,14	methadone	CYP2B6	MESH:D008691	1555	Chemical	Gene	metabolism|compound|START_ENTITY Role|nmod|metabolism Role|nmod|END_ENTITY	Role of CYP2B6 in stereoselective human methadone metabolism .
21790905	0	methadone	32,41	CYP2B6	0,6	methadone	CYP2B6	MESH:D008691	1555	Chemical	Gene	dose|amod|START_ENTITY associated|nmod|dose associated|nsubjpass|SNPs SNPs|compound|END_ENTITY	CYP2B6 SNPs are associated with methadone dose required for effective treatment of opioid_addiction .
22815312	0	methadone	111,120	CYP2B6	27,33	methadone	CYP2B6	MESH:D008691	1555	Chemical	Gene	clearance|amod|START_ENTITY explanation|nmod|clearance prediction|dep|explanation prediction|nmod|induction induction|nummod|END_ENTITY	Quantitative prediction of CYP2B6 induction by estradiol during pregnancy : potential explanation for increased methadone clearance during pregnancy .
23249875	0	methadone	57,66	CYP2B6	16,22	methadone	CYP2B6	MESH:D008691	1555	Chemical	Gene	levels|amod|START_ENTITY extreme|dep|levels alleles|nmod|extreme alleles|nsubj|Contribution Contribution|nmod|END_ENTITY	Contribution of CYP2B6 alleles in explaining extreme -LRB- S -RRB- - methadone plasma levels : a CYP2B6 gene resequencing study .
23249875	0	methadone	57,66	CYP2B6	84,90	methadone	CYP2B6	MESH:D008691	1555	Chemical	Gene	levels|amod|START_ENTITY levels|dep|study study|amod|END_ENTITY	Contribution of CYP2B6 alleles in explaining extreme -LRB- S -RRB- - methadone plasma levels : a CYP2B6 gene resequencing study .
23288240	0	methadone	58,67	CYP2B6	34,40	methadone	CYP2B6	MESH:D008691	1555	Chemical	Gene	metabolites|amod|START_ENTITY interacted|nmod|metabolites interacted|nmod|polymorphisms polymorphisms|nummod|END_ENTITY	PXR polymorphisms interacted with CYP2B6 polymorphisms on methadone metabolites .
24489693	0	methadone	52,61	CYP2B6	20,26	methadone	CYP2B6	MESH:D008691	1555	Chemical	Gene	response|amod|START_ENTITY polymorphisms|nmod|response polymorphisms|nummod|END_ENTITY	Impact of ABCB1 and CYP2B6 genetic polymorphisms on methadone metabolism , dose and treatment response in patients with opioid addiction : a systematic review and meta-analysis .
17234366	0	methadone	100,109	CYP2D6	15,21	methadone	CYP2D6	MESH:D008691	1565	Chemical	Gene	treatment|amod|START_ENTITY satisfaction|nmod|treatment ultrarapid|nmod|satisfaction ultrarapid|nsubj|Association Association|nmod|END_ENTITY	Association of CYP2D6 ultrarapid metabolizer genotype with deficient patient satisfaction regarding methadone maintenance treatment .
22092298	0	methadone	75,84	CYP2D6	19,25	methadone	CYP2D6	MESH:D008691	1565	Chemical	Gene	subjects|amod|START_ENTITY using|nmod|subjects inhibits|parataxis|using inhibits|dobj|END_ENTITY	Methadone inhibits CYP2D6 and UGT2B7/2B4 in vivo : a study using codeine in methadone - and buprenorphine-maintained subjects .
26968424	0	methadone	71,80	CYP2D6	26,32	methadone	CYP2D6	MESH:D008691	1565	Chemical	Gene	metabolism|nmod|START_ENTITY isoforms|nmod|metabolism isoforms|nsubj|allelic allelic|compound|END_ENTITY	In vitro assessment of 24 CYP2D6 allelic isoforms on the metabolism of methadone .
8448065	0	methadone	52,61	CYP2D6	41,47	methadone	CYP2D6	MESH:D008691	1565	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of human cytochrome_P450_2D6 -LRB- CYP2D6 -RRB- by methadone .
18460585	0	methadone	40,49	CYP3A5	8,14	methadone	CYP3A5	MESH:D008691	1577	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of CYP3A5 in abnormal clearance of methadone .
15876424	0	methadone	53,62	P-glycoprotein	8,22	methadone	P-glycoprotein	MESH:D008691	5243	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of P-glycoprotein in transplacental transfer of methadone .
16531639	0	methadone	11,20	c-Fos	37,42	methadone	c-Fos	MESH:D008691	314322(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|amod|END_ENTITY	Effects of methadone and morphine on c-Fos expression in the rat brain : similarities and differences .
23361846	0	methadone	30,39	cytochrome_P4502B6	8,26	methadone	cytochrome P4502B6	MESH:D008691	1555	Chemical	Gene	metabolism|amod|START_ENTITY Role|nmod|metabolism Role|nmod|END_ENTITY	Role of cytochrome_P4502B6 in methadone metabolism and clearance .
12895196	0	methadone	88,97	cytochrome_P450_2D6	22,41	methadone	cytochrome P450 2D6	MESH:D008691	1565	Chemical	Gene	treatment|amod|START_ENTITY undergoing|dobj|treatment patients|acl|undergoing genotype|nmod|patients genotype|nsubj|discordance discordance|nmod|END_ENTITY	A discordance between cytochrome_P450_2D6 genotype and phenotype in patients undergoing methadone maintenance treatment .
8448065	0	methadone	52,61	cytochrome_P450_2D6	20,39	methadone	cytochrome P450 2D6	MESH:D008691	1565	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of human cytochrome_P450_2D6 -LRB- CYP2D6 -RRB- by methadone .
3211364	0	methadone	32,41	enkephalin	63,73	methadone	enkephalin	MESH:D008691	29237(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Effects of exposure in utero to methadone and buprenorphine on enkephalin levels in the developing rat brain .
8872371	0	methadone	55,64	enkephalin	93,103	methadone	enkephalin	MESH:D008691	29237(Tax:10116)	Chemical	Gene	abstinence|nmod|START_ENTITY decrease|nmod|abstinence decrease|appos|inhibitor inhibitor|nmod|catabolism catabolism|compound|END_ENTITY	Similar decrease in spontaneous morphine abstinence by methadone and RB_101 , an inhibitor of enkephalin catabolism .
3697773	0	methadone	19,28	monoamine_oxidase	84,101	methadone	monoamine oxidase	MESH:D008691	29253(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY Effect|nmod|administration Effect|nmod|END_ENTITY	Effect of maternal methadone administration on the development of multiple forms of monoamine_oxidase in rat brain and liver .
1781739	0	methamidophos	15,28	acetylcholinesterase	48,68	methamidophos	acetylcholinesterase	MESH:C014655	43	Chemical	Gene	Interaction|nmod|START_ENTITY END_ENTITY|nsubj|Interaction	Interaction of methamidophos with hen and human acetylcholinesterase and neuropathy_target_esterase .
25535039	0	methamidophos	17,30	paraoxonase_1	34,47	methamidophos	paraoxonase 1	MESH:C014655	84024(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Toxic effects of methamidophos on paraoxonase_1 activity and on rat kidney and liver and ameliorating effects of alpha-tocopherol .
8764599	0	methamphetamine	114,129	Activator_protein-1	0,19	methamphetamine	Activator protein-1	MESH:D008694	24516(Tax:10116)	Chemical	Gene	activities|nmod|START_ENTITY activities|amod|END_ENTITY	Activator_protein-1 binding activities in discrete regions of rat brain after acute and chronic administration of methamphetamine .
24475032	0	methamphetamine	111,126	CRH	25,28	methamphetamine	CRH	MESH:D008694	81648(Tax:10116)	Chemical	Gene	upregulation|nmod|START_ENTITY upregulation|nmod|expression expression|compound|END_ENTITY	Enhanced upregulation of CRH mRNA expression in the nucleus accumbens of male rats after a second injection of methamphetamine given thirty days later .
12433800	0	methamphetamine	81,96	CYP2D6	27,33	methamphetamine	CYP2D6	MESH:D008694	1565	Chemical	Gene	impurity|nmod|START_ENTITY chloroephedrine|appos|impurity inhibition|dep|chloroephedrine inhibition|acl|END_ENTITY	Irreversible inhibition of CYP2D6 by -LRB- - -RRB- - chloroephedrine , a possible impurity in methamphetamine .
17389081	0	methamphetamine	30,45	CYP2D6	151,157	methamphetamine	CYP2D6	MESH:D008694	1565	Chemical	Gene	Determination|nmod|START_ENTITY Determination|nmod|spectrometry spectrometry|nmod|phenotype phenotype|nummod|END_ENTITY	Determination of amphetamine , methamphetamine , and hydroxyamphetamine derivatives in urine by gas chromatography-mass spectrometry and its relation to CYP2D6 phenotype of drug users .
18280655	0	methamphetamine	54,69	CYP2D6	8,14	methamphetamine	CYP2D6	MESH:D008694	1565	Chemical	Gene	dependence|amod|START_ENTITY factor|nmod|dependence factor|nsubj|activity activity|compound|END_ENTITY	Reduced CYP2D6 activity is a negative risk factor for methamphetamine dependence .
23855716	0	methamphetamine	36,51	CYP2D6	17,23	methamphetamine	CYP2D6	MESH:D008694	1565	Chemical	Gene	heart_failure|amod|START_ENTITY predict|dobj|heart_failure predict|nsubj|Polymorphisms Polymorphisms|nmod|END_ENTITY	Polymorphisms in CYP2D6 may predict methamphetamine related heart_failure .
9311621	0	methamphetamine	13,28	CYP2D6	66,72	methamphetamine	CYP2D6	MESH:D008694	1565	Chemical	Gene	Oxidation|nmod|START_ENTITY Oxidation|nmod|END_ENTITY	Oxidation of methamphetamine and methylenedioxymethamphetamine by CYP2D6 .
21707617	0	methamphetamine	109,124	Dopamine_D1_receptor	0,20	methamphetamine	Dopamine D1 receptor	MESH:D008694	13488(Tax:10090)	Chemical	Gene	regulates|advcl|START_ENTITY regulates|nsubj|END_ENTITY	Dopamine_D1_receptor signaling system regulates ryanodine_receptor expression after intermittent exposure to methamphetamine in primary cultures of midbrain and cerebral cortical neurons .
23159329	0	methamphetamine	18,33	ERK	137,140	methamphetamine	ERK	MESH:D008694	26413(Tax:10090)	Chemical	Gene	roles|nmod|START_ENTITY roles|nmod|END_ENTITY	Distinct roles of methamphetamine in modulating spatial memory consolidation , retrieval , reconsolidation and the accompanying changes of ERK and CREB activation in hippocampus and prefrontal cortex .
11085315	0	methamphetamine	98,113	GDNF	23,27	methamphetamine	GDNF	MESH:D008694	25453(Tax:10116)	Chemical	Gene	doses|nmod|START_ENTITY treated|nmod|doses treated|nsubj|effects effects|nmod|END_ENTITY	Restorative effects of GDNF on striatal dopamine release in rats treated with neurotoxic doses of methamphetamine .
17105923	0	methamphetamine	107,122	GDNF	14,18	methamphetamine	GDNF	MESH:D008694	25453(Tax:10116)	Chemical	Gene	Protection|nmod|START_ENTITY Protection|nmod|END_ENTITY	Protection by GDNF and other trophic factors against the dopamine-depleting effects of neurotoxic doses of methamphetamine .
21514351	0	methamphetamine	43,58	GDNF	28,32	methamphetamine	GDNF	MESH:D008694	2668	Chemical	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Association analysis of the GDNF gene with methamphetamine use disorder in a Japanese population .
23432945	0	methamphetamine	60,75	GDNF	31,35	methamphetamine	GDNF	MESH:D008694	14573(Tax:10090)	Chemical	Gene	self-administration|amod|START_ENTITY attenuates|dobj|self-administration attenuates|nsubj|delivery delivery|nmod|END_ENTITY	Intrastriatal gene delivery of GDNF persistently attenuates methamphetamine self-administration and relapse in mice .
8987838	0	methamphetamine	100,115	GDNF	0,4	methamphetamine	GDNF	MESH:D008694	25453(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY neurons|nmod|effects protects|nmod|neurons protects|nsubj|END_ENTITY	GDNF selectively protects dopamine neurons over serotonin neurons against the neurotoxic effects of methamphetamine .
26254235	0	methamphetamine	88,103	HMGB1	40,45	methamphetamine	HMGB1	MESH:D008694	25459(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY mediates|dobj|effects mediates|nsubj|END_ENTITY	The danger-associated molecular pattern HMGB1 mediates the neuroinflammatory effects of methamphetamine .
12675928	0	methamphetamine	87,102	NF68	54,58	methamphetamine	NF68	MESH:D008694	18039(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	The nNOS inhibitor , AR-R17477AR , prevents the loss of NF68 immunoreactivity induced by methamphetamine in the mouse striatum .
16109587	0	methamphetamine	35,50	Narp	54,58	methamphetamine	Narp	MESH:D008694	288475(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|mRNA mRNA|compound|END_ENTITY	Effects of acute administration of methamphetamine on Narp mRNA in rat brain .
18479746	0	methamphetamine	22,37	Nociceptin	0,10	methamphetamine	Nociceptin	MESH:D008694	5368	Chemical	Gene	START_ENTITY|nsubj|attenuates attenuates|compound|END_ENTITY	Nociceptin attenuates methamphetamine abstinence-induced withdrawal-like behavior in planarians .
22715419	0	methamphetamine	53,68	PDIA3	44,49	methamphetamine	PDIA3	MESH:D008694	2923	Chemical	Gene	neurotoxicity|amod|START_ENTITY END_ENTITY|nmod|neurotoxicity	Protective role for the disulfide isomerase PDIA3 in methamphetamine neurotoxicity .
23239345	0	methamphetamine	48,63	Thioredoxin-1	0,13	methamphetamine	Thioredoxin-1	MESH:D008694	116484(Tax:10116)	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Thioredoxin-1 was required for CREB activity by methamphetamine in rat pheochromocytoma cells .
17218486	0	methamphetamine	94,109	Trace_amine-associated_receptor_1	0,33	methamphetamine	Trace amine-associated receptor 1	MESH:D008694	134864	Chemical	Gene	isomers|acl|START_ENTITY displays|nmod|isomers displays|nsubj|END_ENTITY	Trace_amine-associated_receptor_1 displays species-dependent stereoselectivity for isomers of methamphetamine , amphetamine , and para-hydroxyamphetamine .
2882825	0	methamphetamine	147,162	Tyrosine_hydroxylase	0,20	methamphetamine	Tyrosine hydroxylase	MESH:D008694	25085(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY effects|nmod|administration immunochemistry|dep|effects immunochemistry|amod|END_ENTITY	Tyrosine_hydroxylase immunochemistry and quantitative light microscopic studies of the mesolimbic dopamine system in rat brain : effects of chronic methamphetamine administration .
17105913	0	methamphetamine	25,40	VMAT-2	44,50	methamphetamine	VMAT-2	MESH:D008694	25549(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Age-dependent effects of methamphetamine on VMAT-2 .
8959020	0	methamphetamine	46,61	activator_protein-1	65,84	methamphetamine	activator protein-1	MESH:D008694	24516(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activities activities|amod|END_ENTITY	Effect of acute and chronic administration of methamphetamine on activator_protein-1 binding activities in the rat brain regions .
17233643	0	methamphetamine	50,65	beta-arrestin_2	24,39	methamphetamine	beta-arrestin 2	MESH:D008694	409	Chemical	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Possible association of beta-arrestin_2 gene with methamphetamine use disorder , but not schizophrenia .
9519252	0	methamphetamine	75,90	c-Fos	47,52	methamphetamine	c-Fos	MESH:D008694	14281(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY expression|acl|induced expression|amod|END_ENTITY	Lithium inhibits the reverse tolerance and the c-Fos expression induced by methamphetamine in mice .
9313897	0	methamphetamine	94,109	calmodulin	15,25	methamphetamine	calmodulin	MESH:D008694	24242(Tax:10116)	Chemical	Gene	Alterations|nmod|START_ENTITY Alterations|nmod|END_ENTITY	Alterations of calmodulin and its mRNA in rat brain after acute and chronic administration of methamphetamine .
19050854	0	methamphetamine	74,89	casein_kinase_1_epsilon	11,34	methamphetamine	casein kinase 1 epsilon	MESH:D008694	27373(Tax:10090)	Chemical	Gene	role|acl|START_ENTITY role|nmod|END_ENTITY	A role for casein_kinase_1_epsilon in the locomotor stimulant response to methamphetamine .
23022510	0	methamphetamine	23,38	heme_oxygenase-1	99,115	methamphetamine	heme oxygenase-1	MESH:D008694	3162	Chemical	Gene	START_ENTITY|advcl|enhancing enhancing|xcomp|END_ENTITY	L-ascorbate attenuates methamphetamine neurotoxicity through enhancing the induction of endogenous heme_oxygenase-1 .
19912807	0	methamphetamine	77,92	interleukin-1beta	51,68	methamphetamine	interleukin-1beta	MESH:D008694	24494(Tax:10116)	Chemical	Gene	mRNA|nmod|START_ENTITY mRNA|amod|END_ENTITY	In situ hybridization analysis of the induction of interleukin-1beta mRNA by methamphetamine in the rat hypothalamus .
16146580	0	methamphetamine	49,64	neuroglycan_C	80,93	methamphetamine	neuroglycan C	MESH:D008694	50568(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|amod|END_ENTITY	Effects of single and repeated administration of methamphetamine or morphine on neuroglycan_C gene expression in the rat brain .
15780475	0	methamphetamine	24,39	neuropeptide_Y	57,71	methamphetamine	neuropeptide Y	MESH:D008694	24604(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|rats rats|nmod|expression expression|nmod|mRNA mRNA|amod|END_ENTITY	Differential effects of methamphetamine on expression of neuropeptide_Y mRNA in hypothalamus and on serum leptin and ghrelin concentrations in ad libitum-fed and schedule-fed rats .
22805317	0	methamphetamine	97,112	neuropeptide_Y	19,33	methamphetamine	neuropeptide Y	MESH:D008694	109648(Tax:10090)	Chemical	Gene	injury|amod|START_ENTITY death|nmod|injury receptors|nmod|death Y|dobj|receptors Y|nsubj|role role|nmod|END_ENTITY	Protective role of neuropeptide_Y Y receptors in cell death and microglial response following methamphetamine injury .
1463283	0	methamphetamine	67,82	neurotensin	29,40	methamphetamine	neurotensin	MESH:D008694	4922	Chemical	Gene	induced|nmod|START_ENTITY concentrations|acl|induced concentrations|compound|END_ENTITY	MK-801 blocks the changes in neurotensin concentrations induced by methamphetamine , 3,4-methylenedioxymethamphetamine , cocaine , and GBR_12909 .
16199030	0	methamphetamine	60,75	neurotensin	13,24	methamphetamine	neurotensin	MESH:D008694	4922	Chemical	Gene	regions|amod|START_ENTITY doses|nmod|regions Differential|nmod|doses Differential|dobj|responses responses|compound|END_ENTITY	Differential neurotensin responses to low and high doses of methamphetamine in the terminal regions of striatal efferents .
18991855	0	methamphetamine	40,55	neurotensin	25,36	methamphetamine	neurotensin	MESH:D008694	299757(Tax:10116)	Chemical	Gene	response|acl|START_ENTITY response|nmod|END_ENTITY	Differential response of neurotensin to methamphetamine self-administration .
21131268	0	methamphetamine	10,25	neurotensin	49,60	methamphetamine	neurotensin	MESH:D008694	299757(Tax:10116)	Chemical	Gene	self-administration|amod|START_ENTITY Effect|nmod|self-administration Effect|nmod|systems systems|compound|END_ENTITY	Effect of methamphetamine self-administration on neurotensin systems of the basal ganglia .
22245499	0	methamphetamine	42,57	neurotensin	19,30	methamphetamine	neurotensin	MESH:D008694	299757(Tax:10116)	Chemical	Gene	Response|acl|START_ENTITY Response|nmod|systems systems|compound|END_ENTITY	Response of limbic neurotensin systems to methamphetamine self-administration .
23685547	0	methamphetamine	67,82	neurotensin	12,23	methamphetamine	neurotensin	MESH:D008694	299757(Tax:10116)	Chemical	Gene	self-administration|amod|START_ENTITY extinction|nmod|self-administration basal|nmod|extinction basal|nsubj|Response Response|nmod|END_ENTITY	Response of neurotensin basal ganglia systems during extinction of methamphetamine self-administration in rat .
3572804	0	methamphetamine	10,25	neurotensin	29,40	methamphetamine	neurotensin	MESH:D008694	299757(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|concentrations concentrations|compound|END_ENTITY	Effect of methamphetamine on neurotensin concentrations in rat brain regions .
7517773	0	methamphetamine	66,81	neurotensin	17,28	methamphetamine	neurotensin	MESH:D008694	299757(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY striatum|nmod|treatment striatum|nsubj|Up-regulation Up-regulation|nmod|mRNA mRNA|compound|END_ENTITY	Up-regulation of neurotensin mRNA in the rat striatum after acute methamphetamine treatment .
8182549	0	methamphetamine	94,109	neurotensin	13,24	methamphetamine	neurotensin	MESH:D008694	299757(Tax:10116)	Chemical	Gene	neostriatum|nmod|START_ENTITY subregions|nmod|neostriatum mRNA|nmod|subregions mRNA|compound|END_ENTITY	Induction of neurotensin and c-fos mRNA in distinct subregions of rat neostriatum after acute methamphetamine : comparison with acute haloperidol effects .
23932974	0	methamphetamine	71,86	nuclear_factor_E2-related_factor_2	22,56	methamphetamine	nuclear factor E2-related factor 2	MESH:D008694	18024(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	Developmental role of nuclear_factor_E2-related_factor_2 in mitigating methamphetamine fetal toxicity and postnatal_neurodevelopmental_deficits .
25853370	0	methamphetamine	42,57	oxytocin	80,88	Methamphetamine	oxytocin	MESH:D008694	5020	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Effects of acute doses of prosocial drugs methamphetamine and alcohol on plasma oxytocin levels .
25779436	0	methamphetamine	67,82	sigma-1_receptor	15,31	methamphetamine	sigma-1 receptor	MESH:D008694	18391(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of sigma-1_receptor in astrocyte activation induced by methamphetamine via up-regulation of its own expression .
15298655	0	methamphetamine	43,58	synaptotagmin_IV	81,97	methamphetamine	synaptotagmin IV	MESH:D008694	64440(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effect of acute and chronic treatment with methamphetamine on mRNA expression of synaptotagmin_IV and 25 KDa-synaptic-associated protein in the rat brain .
6104722	0	methamphetamine	39,54	tryptophan_hydroxylase	58,80	methamphetamine	tryptophan hydroxylase	MESH:D008694	24848(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activity activity|amod|END_ENTITY	Long-term effects of multiple doses of methamphetamine on tryptophan_hydroxylase and tyrosine_hydroxylase activity in rat brain .
12105086	0	methamphetamine	21,36	tyrosine_hydroxylase	61,81	methamphetamine	tyrosine hydroxylase	MESH:D008694	25085(Tax:10116)	Chemical	Gene	exposure|acl|START_ENTITY exposure|dep|ontogeny ontogeny|nmod|expression expression|amod|END_ENTITY	Prenatal exposure to methamphetamine in the rat : ontogeny of tyrosine_hydroxylase mRNA expression in mesencephalic dopaminergic neurons .
16555063	0	methamphetamine	10,25	tyrosine_hydroxylase	49,69	methamphetamine	tyrosine hydroxylase	MESH:D008694	25085(Tax:10116)	Chemical	Gene	self-administration|amod|START_ENTITY self-administration|nmod|levels levels|compound|END_ENTITY	Effect of methamphetamine self-administration on tyrosine_hydroxylase and dopamine_transporter levels in mesolimbic and nigrostriatal dopamine pathways of the rat .
22329540	0	methamphetamine	23,38	tyrosine_hydroxylase	42,62	methamphetamine	tyrosine hydroxylase	MESH:D008694	21823(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|transport transport|amod|END_ENTITY	Differential action of methamphetamine on tyrosine_hydroxylase and dopamine transport in the nigrostriatal pathway of - opioid receptor knockout mice .
6286	0	methamphetamine	13,28	tyrosine_hydroxylase	52,72	methamphetamine	tyrosine hydroxylase	MESH:D008694	25085(Tax:10116)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|activity activity|compound|END_ENTITY	Influence of methamphetamine on nigral and striatal tyrosine_hydroxylase activity and on striatal dopamine levels .
7888148	0	methamphetamine	38,53	tyrosine_hydroxylase	129,149	methamphetamine	tyrosine hydroxylase	MESH:D008694	7054	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|transgenic_mice transgenic_mice|acl|expressing expressing|dobj|gene gene|compound|END_ENTITY	Effects of subacute administration of methamphetamine and nicotine on locomotor activity in transgenic_mice expressing the human tyrosine_hydroxylase gene .
8923661	0	methamphetamine	60,75	tyrosine_hydroxylase	79,99	methamphetamine	tyrosine hydroxylase	MESH:D008694	25085(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|levels levels|amod|END_ENTITY	Contrasting effects of repeated treatment vs. withdrawal of methamphetamine on tyrosine_hydroxylase messenger RNA levels in the ventral tegmental area and substantia nigra zona compacta of the rat brain .
9450687	0	methamphetamine	6,21	tyrosine_hydroxylase	47,67	methamphetamine	tyrosine hydroxylase	MESH:D008694	25085(Tax:10116)	Chemical	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	Acute methamphetamine administration increases tyrosine_hydroxylase mRNA levels in the rat locus coeruleus .
10087057	0	methamphetamine	10,25	vesicular_monoamine_transporter_2	56,89	methamphetamine	vesicular monoamine transporter 2	MESH:D008694	214084(Tax:10090)	Chemical	Gene	neurotoxicity|amod|START_ENTITY neurotoxicity|nmod|mice mice|amod|END_ENTITY	Increased methamphetamine neurotoxicity in heterozygous vesicular_monoamine_transporter_2 knock-out mice .
17683483	0	methamphetamine	89,104	vesicular_monoamine_transporter_2	49,82	methamphetamine	vesicular monoamine transporter 2	MESH:D008694	6571	Chemical	Gene	oxidation|nmod|START_ENTITY oxidation|nmod|END_ENTITY	A rapid oxidation and persistent decrease in the vesicular_monoamine_transporter_2 after methamphetamine .
8614278	0	methanandamide	26,40	CB1	82,85	methanandamide	CB1	MESH:C088155	25248(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|receptor receptor|compound|END_ENTITY	Extrapyramidal effects of methanandamide , an analog of anandamide , the endogenous CB1 receptor ligand .
17067801	0	methanesulfonyl	97,112	cyclooxygenase-2	145,161	methanesulfonyl	cyclooxygenase-2	null	5743	Chemical	Gene	selectivity|amod|START_ENTITY selectivity|amod|END_ENTITY	Synthesis and biological evaluation of methanesulfonamide analogues of rofecoxib : Replacement of methanesulfonyl by methanesulfonamido decreases cyclooxygenase-2 selectivity .
15964079	0	methanesulfonyl_fluoride	56,80	acetylcholinesterase	25,45	methanesulfonyl fluoride	acetylcholinesterase	MESH:C005109	83817(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|exposure exposure|nmod|inhibitor inhibitor|amod|END_ENTITY	Prenatal exposure to the acetylcholinesterase inhibitor methanesulfonyl_fluoride alters forebrain morphology and gene expression .
9845338	0	methanogens	153,164	elongation_factor_2	76,95	methanogens	elongation factor 2	null	1938	Chemical	Gene	proteins|nmod|START_ENTITY proteins|amod|END_ENTITY	Archaeal cold-adapted proteins : structural and evolutionary analysis of the elongation_factor_2 proteins from psychrophilic , mesophilic and thermophilic methanogens .
9783425	0	methanogens	52,63	serine_hydroxymethyltransferase	17,48	methanogens	serine hydroxymethyltransferase	null	9705478	Chemical	Gene	Investigation|nmod|START_ENTITY Investigation|nmod|END_ENTITY	Investigation of serine_hydroxymethyltransferase in methanogens .
21778980	0	methanol	103,111	CO2	121,124	methanol	CO2	MESH:D000432	717	Chemical	Gene	START_ENTITY|acl|based based|nmod|END_ENTITY	Efficient hydrogenation of organic carbonates , carbamates and formates indicates alternative routes to methanol based on CO2 and CO. .
18288452	0	methanol	97,105	Glial_fibrillary_acidic_protein	0,31	methanol	Glial fibrillary acidic protein	MESH:D000432	2670	Chemical	Gene	toxicity|compound|START_ENTITY END_ENTITY|nmod|toxicity	Glial_fibrillary_acidic_protein -LRB- GFAP -RRB- and CD34 expression in the human optic nerve and brain in methanol toxicity .
24342777	0	methanol	67,75	Syk	0,3	methanol	Syk	MESH:D000432	20963(Tax:10090)	Chemical	Gene	targets|nmod|START_ENTITY targets|nsubj|END_ENTITY	Syk and Src are major pharmacological targets of a Cerbera manghas methanol extract with kaempferol-based anti-inflammatory activity .
19283282	0	methanol	62,70	cytochrome_c	46,58	methanol	cytochrome c	MESH:D000432	54205	Chemical	Gene	increase|nmod|START_ENTITY increase|nmod|END_ENTITY	Reversible increase in the redox potential of cytochrome_c in methanol .
3947051	0	methicillin	57,68	albumin	94,101	methicillin	albumin	MESH:D008712	213	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Microcalorimetric study of the effect of temperature on methicillin binding with human serum albumin -RSB- .
24364474	0	methimazole	25,36	Bcl-2	44,49	methimazole	Bcl-2	MESH:D008713	596	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Impact of treatment with methimazole on the Bcl-2 expression in CD8 + peripheral blood lymphocytes in children with Graves ' _ disease .
9614932	0	methimazole	140,151	CD69	9,13	methimazole	CD69	MESH:D008713	969	Chemical	Gene	effect|nmod|START_ENTITY expression|dep|effect expression|compound|END_ENTITY	Elevated CD69 expression on naive peripheral blood T-cells in hyperthyroid Graves ' _ disease and autoimmune_thyroiditis : discordant effect of methimazole on HLA-DR and CD69 .
24364474	0	methimazole	25,36	CD8	64,67	methimazole	CD8	MESH:D008713	925	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Impact of treatment with methimazole on the Bcl-2 expression in CD8 + peripheral blood lymphocytes in children with Graves ' _ disease .
9208626	0	methimazole	11,22	glucocorticoid_receptor	54,77	methimazole	glucocorticoid receptor	MESH:D008713	2908	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of methimazole and dexamethasone on leucocyte glucocorticoid_receptor , plasma ACTH , and cortisol levels in Graves ' _ disease -RSB- .
3098461	0	methimazole	32,43	interleukin-1	47,60	methimazole	interleukin-1	MESH:D008713	3552	Chemical	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	Effect of the anti-thyroid drug methimazole on interleukin-1 and interleukin-2 levels in vitro .
24703463	0	methimazole	38,49	tyrosinase	74,84	methimazole	tyrosinase	MESH:D008713	22173(Tax:10090)	Chemical	Gene	derivatives|compound|START_ENTITY effects|nmod|derivatives END_ENTITY|nsubj|effects	Inhibitory effects of novel synthetic methimazole derivatives on mushroom tyrosinase and melanogenesis .
26633377	6	methimazole	776,787	tyrosinase	865,875	methimazole	tyrosinase	MESH:D008713	22173(Tax:10090)	Chemical	Gene	was|nmod|START_ENTITY was|nsubj|information information|nmod|activity activity|nmod|drugs drugs|nmod|END_ENTITY	Except for methimazole , there was limited information regarding the activity of other drugs against tyrosinase .
3091005	0	methimazole	10,21	tyrosinase	50,60	methimazole	tyrosinase	MESH:D008713	7299	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of methimazole on the activity of mushroom tyrosinase .
15771452	0	methimepip	57,67	histamine_H3_receptor	94,115	methimepip	histamine H3 receptor	null	11255	Chemical	Gene	START_ENTITY|nmod|agonist agonist|amod|END_ENTITY	N-substituted_piperidinyl_alkyl_imidazoles : discovery of methimepip as a potent and selective histamine_H3_receptor agonist .
10362526	0	methionine	44,54	B12	67,70	methionine	B12	MESH:D008715	4709	Chemical	Gene	regulation|nmod|START_ENTITY synthase|nsubj|regulation synthase|nmod|END_ENTITY	Posttranscriptional regulation of mammalian methionine synthase by B12 .
3991360	0	methionine	23,33	CCK	46,49	methionine	CCK	MESH:D008715	885	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Oxidation/reduction of methionine residues in CCK : a study by radioimmunoassay and isocratic reverse phase high pressure liquid chromatography .
26235215	0	methionine	29,39	CTR1	49,53	methionine	CTR1	MESH:D008715	1317	Chemical	Gene	motif|compound|START_ENTITY motif|nmod|END_ENTITY	The reaction of a platinated methionine motif of CTR1 with cysteine and histidine is dependent upon the type of precursor platinum complex .
11544402	0	methionine	49,59	ICAM-1	103,109	methionine	ICAM-1	MESH:D008715	3383	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Absence of association between the allele coding methionine at position 29 in the N-terminal domain of ICAM-1 -LRB- ICAM-1 -LRB- Kilifi -RRB- -RRB- and severe malaria in the northwest of Thailand .
12176673	0	methionine	49,59	IGF-I	112,117	methionine	IGF-I	MESH:D008715	443318(Tax:9940)	Chemical	Gene	supply|amod|START_ENTITY liver|dep|supply interaction|nmod|liver modulates|nsubj|interaction modulates|dobj|expression expression|amod|END_ENTITY	Nutrient-hormone interaction in the ovine liver : methionine supply selectively modulates growth_hormone-induced IGF-I gene expression .
24390990	0	methionine	8,18	IGF-I	30,35	methionine	IGF-I	MESH:D008715	3479	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Dietary methionine effects on IGF-I and GHR mRNA expression in broilers .
24615098	0	methionine	30,40	IGF-I	52,57	methionine	IGF-I	MESH:D008715	3479	Chemical	Gene	effects|amod|START_ENTITY dietary|dobj|effects dietary|nmod|END_ENTITY	Acute heat_stress and dietary methionine effects on IGF-I , GHR , and UCP mRNA expression in liver and muscle of quails .
21256596	0	methionine	10,20	IgG1	40,44	methionine	IgG1	MESH:D008715	105243590	Chemical	Gene	oxidation|amod|START_ENTITY oxidation|nmod|END_ENTITY	Impact of methionine oxidation in human IgG1 Fc on serum half-life of monoclonal antibodies .
4098371	0	methionine	54,64	L-asparaginase	36,50	methionine	L-asparaginase	MESH:D008715	80150	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of anti-tumour effect of L-asparaginase by methionine and choline .
22022143	0	methionine	44,54	MTHFR	29,34	methionine	MTHFR	MESH:D008715	4524	Chemical	Gene	START_ENTITY|nsubj|interactions interactions|nmod|END_ENTITY	Genetic interactions between MTHFR -LRB- C677T -RRB- , methionine synthase -LRB- A2756G , C2758G -RRB- variants with vitamin_B12 and folic_acid determine susceptibility to premature coronary_artery_disease in Indian population .
16405428	0	methionine	138,148	NF-kappaB	89,98	methionine	NF-kappaB	MESH:D008715	4790	Chemical	Gene	oxidation|amod|START_ENTITY END_ENTITY|nmod|oxidation	IkappaB is a sensitive target for oxidation by cell-permeable chloramines : inhibition of NF-kappaB activity by glycine_chloramine through methionine oxidation .
26267336	0	methionine	6,16	Sup35	0,5	methionine	Sup35	MESH:D008715	851752(Tax:4932)	Chemical	Gene	oxidation|compound|START_ENTITY oxidation|amod|END_ENTITY	Sup35 methionine oxidation is a trigger for de novo -LSB- PSI -LRB- + -RRB- -RSB- prion formation .
26267336	0	methionine	6,16	Sup35	0,5	methionine	Sup35	MESH:D008715	851752(Tax:4932)	Chemical	Gene	oxidation|compound|START_ENTITY oxidation|amod|END_ENTITY	Sup35 methionine oxidation is a trigger for de novo -LSB- PSI -LRB- + -RRB- -RSB- prion formation .
8620451	0	methionine	15,25	WISH	109,113	methionine	WISH	MESH:D008715	51517	Chemical	Gene	cells|amod|START_ENTITY cells|appos|END_ENTITY	Involvement of methionine in the synthesis of certain membrane-associated nucleotide sugars by human amnion -LRB- WISH -RRB- cells .
3121196	0	methionine	56,66	alcohol_dehydrogenase	88,109	methionine	alcohol dehydrogenase	MESH:D008715	78959(Tax:10116)	Chemical	Gene	residue|compound|START_ENTITY residue|nmod|END_ENTITY	The binding of an aminoazo dye carcinogen to a specific methionine residue in rat liver alcohol_dehydrogenase in vivo .
6174466	0	methionine	50,60	alpha-fetoprotein	18,35	methionine	alpha-fetoprotein	MESH:D008715	24177(Tax:10116)	Chemical	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Regulation of rat alpha-fetoprotein production by methionine during ethionine-hepatocarcinogenesis .
6177022	0	methionine	13,23	alpha-fetoprotein	48,65	methionine	alpha-fetoprotein	MESH:D008715	24177(Tax:10116)	Chemical	Gene	administration|amod|START_ENTITY Influence|nmod|administration Influence|nmod|levels levels|amod|END_ENTITY	Influence of methionine administration on serum alpha-fetoprotein levels in ethionine-injured rats .
77035	0	methionine	50,60	alpha-fetoprotein	18,35	methionine	alpha-fetoprotein	MESH:D008715	24177(Tax:10116)	Chemical	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Regulation of rat alpha-fetoprotein production by methionine and adenosine_5 ' - triphosphate .
18576673	0	methionine	139,149	aminopeptidase	169,183	methionine	aminopeptidase	MESH:D008715	10404	Chemical	Gene	residue|amod|START_ENTITY residue|nmod|END_ENTITY	Zinc coordination geometry and ligand binding affinity : the structural and kinetic analysis of the second-shell serine 228 residue and the methionine 180 residue of the aminopeptidase from Vibrio proteolyticus .
19797941	0	methionine	54,64	aminopeptidase	21,35	methionine	aminopeptidase	MESH:D008715	10404	Chemical	Gene	degradation|nmod|START_ENTITY degradation|compound|END_ENTITY	Bacitracin-sensitive aminopeptidase -LRB- s -RRB- degradation of methionine -LRB- 5 -RRB- - enkephalin by human brain putamen and hippocampus preparations : inhibition by phenothiazine drugs .
10751387	0	methionine	13,23	apolipoprotein_A-I	116,134	methionine	apolipoprotein A-I	MESH:D008715	335	Chemical	Gene	residues|amod|START_ENTITY Oxidation|nmod|residues decrease|nsubj|Oxidation decrease|dobj|properties properties|nmod|END_ENTITY	Oxidation of methionine residues to methionine_sulfoxides does not decrease potential antiatherogenic properties of apolipoprotein_A-I .
11687233	0	methionine	13,23	apolipoprotein_A-I	72,90	methionine	apolipoprotein A-I	MESH:D008715	335	Chemical	Gene	residues|amod|START_ENTITY Oxidation|nmod|residues affects|nsubj|Oxidation affects|dobj|structure structure|nmod|END_ENTITY	Oxidation of methionine residues affects the structure and stability of apolipoprotein_A-I in reconstituted high density lipoprotein particles .
16252306	0	methionine	22,32	apolipoprotein_A-I	60,78	methionine	apolipoprotein A-I	MESH:D008715	335	Chemical	Gene	Oxidation|nmod|START_ENTITY Oxidation|nmod|END_ENTITY	Oxidation of specific methionine and tryptophan residues of apolipoprotein_A-I in hepatocarcinogenesis .
16497665	0	methionine	67,77	apolipoprotein_A-I	131,149	methionine	apolipoprotein A-I	MESH:D008715	335	Chemical	Gene	oxidation|amod|START_ENTITY oxidation|nmod|END_ENTITY	Myeloperoxidase impairs ABCA1-dependent cholesterol efflux through methionine oxidation and site-specific tyrosine chlorination of apolipoprotein_A-I .
7734930	0	methionine	18,28	apolipoprotein_A-I	86,104	methionine	apolipoprotein A-I	MESH:D008715	335	Chemical	Gene	sulphoxidation|amod|START_ENTITY mediated|nsubj|sulphoxidation mediated|dobj|heterogeneity heterogeneity|nmod|END_ENTITY	Mannitol prevents methionine sulphoxidation mediated electrophoretic heterogeneity of apolipoprotein_A-I .
10075673	0	methionine	28,38	betaine-homocysteine_methyltransferase	76,114	methionine	betaine-homocysteine methyltransferase	MESH:D008715	81508(Tax:10116)	Chemical	Gene	Interaction|nmod|START_ENTITY END_ENTITY|nsubj|Interaction	Interaction between dietary methionine and methyl donor intake on rat liver betaine-homocysteine_methyltransferase gene expression and organization of the human gene .
16199479	0	methionine	19,29	calmodulin	8,18	methionine	calmodulin	MESH:D008715	808	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of calmodulin methionine residues in mediating productive association with cardiac ryanodine receptors .
9485473	0	methionine	37,47	calmodulin	81,91	methionine	calmodulin	MESH:D008715	808	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Tryptophan fluorescence quenching by methionine and selenomethionine residues of calmodulin : orientation of peptide and protein binding .
16786305	0	methionine	73,83	cystathionine-gamma-synthase	19,47	methionine	cystathionine-gamma-synthase	MESH:D008715	543920(Tax:4081)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Regulatory role of cystathionine-gamma-synthase and de novo synthesis of methionine in ethylene production during tomato fruit ripening .
1617531	0	methionine	82,92	enkephalin	93,103	methionine	enkephalin	MESH:D008715	29237(Tax:10116)	Chemical	Gene	administration|amod|START_ENTITY administration|compound|END_ENTITY	Microdialysis of noradrenaline in rostral ventrolateral medulla after intravenous methionine enkephalin administration in anesthetized rats .
2423919	0	methionine	51,61	enkephalin	38,48	methionine	enkephalin	MESH:D008715	29237(Tax:10116)	Chemical	Gene	enkephalin|amod|START_ENTITY END_ENTITY|dep|enkephalin	The glutamate_decarboxylase - , leucine enkephalin - , methionine enkephalin - and substance P-immunoreactive neurons in the neostriatum of the rat and cat : evidence for partial population overlap .
3834418	0	methionine	107,117	enkephalin	76,86	methionine	enkephalin	MESH:D008715	29237(Tax:10116)	Chemical	Gene	administration|dep|START_ENTITY administration|nmod|derivatives derivatives|compound|END_ENTITY	Blood pressure responses of conscious rats to intravenous administration of enkephalin derivatives -LRB- D-ala2 methionine and leucine_enkephalinamide , and methionine and leucine_enkephalinamide .
3900010	0	methionine	29,39	enkephalin	73,83	methionine	enkephalin	MESH:D008715	29237(Tax:10116)	Chemical	Gene	residues|amod|START_ENTITY cleavage|nmod|residues bromide|dobj|cleavage bromide|nmod|method method|nmod|immunocytochemistry immunocytochemistry|compound|END_ENTITY	Cyanogen bromide cleavage of methionine residues as a control method for enkephalin immunocytochemistry .
7074991	0	methionine	8,18	enkephalin	19,29	methionine	enkephalin	MESH:D008715	29237(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|immunoreactivity immunoreactivity|compound|END_ENTITY	Altered methionine enkephalin immunoreactivity in cerebral nuclei of spontaneously hypertensive rats .
8883887	0	methionine	87,97	enkephalin	98,108	methionine	enkephalin	MESH:D008715	29237(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|levels levels|compound|END_ENTITY	Effect of low and high doses of nitrous_oxide on preproenkephalin mRNA and its peptide methionine enkephalin levels in the hypothalamus .
23283239	0	methionine	74,84	fibrinogen	97,107	methionine	fibrinogen	MESH:D008715	2244	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Fibrin clot structure and mechanics associated with specific oxidation of methionine residues in fibrinogen .
25736301	0	methionine	74,84	fibroblast_growth_factor_21	8,35	methionine	fibroblast growth factor 21	MESH:D008715	56636(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Role Role|nmod|END_ENTITY	Role of fibroblast_growth_factor_21 in the early stage of NASH induced by methionine - _ and_choline-deficient_diet .
14744147	0	methionine	54,64	granulocyte_colony-stimulating_factor	77,114	methionine	granulocyte colony-stimulating factor	MESH:D008715	1440	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Molecular dynamics simulations and oxidation rates of methionine residues of granulocyte_colony-stimulating_factor at different pH values .
15648272	0	methionine	71,81	granulocyte_colony-stimulating_factor	94,131	methionine	granulocyte colony-stimulating factor	MESH:D008715	1440	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Effects of antioxidants on the hydrogen_peroxide-mediated oxidation of methionine residues in granulocyte_colony-stimulating_factor and human parathyroid hormone fragment 13-34 .
17480058	0	methionine	13,23	interleukin-1_receptor_antagonist	54,87	methionine	interleukin-1 receptor antagonist	MESH:D008715	3557	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Oxidation of methionine residues in recombinant human interleukin-1_receptor_antagonist : implications of conformational stability on protein oxidation kinetics .
9587962	0	methionine	9,19	leptin	51,57	methionine	leptin	MESH:D008715	3952	Chemical	Gene	oxidation|amod|START_ENTITY oxidation|nmod|END_ENTITY	In vitro methionine oxidation of recombinant human leptin .
12566486	0	methionine	8,18	methionine_synthase	53,72	methionine	methionine synthase	MESH:D008715	81522(Tax:10116)	Chemical	Gene	inactivation|amod|START_ENTITY inactivation|nmod|END_ENTITY	Neither methionine nor nitrous_oxide inactivation of methionine_synthase affect the concentration of 5,10-methylenetetrahydrofolate in rat liver .
18625300	0	methionine	27,37	myoglobin	65,74	methionine	myoglobin	MESH:D008715	4151	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	Hypochlorous_acid oxidizes methionine and tryptophan residues in myoglobin .
22785533	0	methionine	78,88	procaspase-3	19,31	methionine	procaspase-3	MESH:D008715	836	Chemical	Gene	oxidation|compound|START_ENTITY oxidation|amod|END_ENTITY	Photofrin binds to procaspase-3 and mediates photodynamic treatment-triggered methionine oxidation and inactivation of procaspase-3 .
8762148	0	methionine	9,19	stem_cell_factor	64,80	methionine	stem cell factor	MESH:D008715	4254	Chemical	Gene	oxidation|amod|START_ENTITY oxidation|nmod|END_ENTITY	In vitro methionine oxidation of Escherichia_coli-derived human stem_cell_factor : effects on the molecular structure , biological activity , and dimerization .
1963472	0	methionine	62,72	tRNA	73,77	methionine	tRNA	MESH:D008715	4563	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	A glucocorticoid response element enhances transcription of a methionine tRNA gene in cis and trans .
23431330	0	methionine	28,38	tRNA	77,81	methionine	tRNA	MESH:D008715	4563	Chemical	Gene	tRNA|compound|START_ENTITY Overexpression|nmod|tRNA leads|nsubj|Overexpression leads|nmod|reprogramming reprogramming|nmod|expression expression|compound|END_ENTITY	Overexpression of initiator methionine tRNA leads to global reprogramming of tRNA expression and increased proliferation in human epithelial cells .
2834094	0	methionine	63,73	tRNA	74,78	methionine	tRNA	MESH:D008715	3989301(Tax:3847)	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Cytochrome oxidase subunit II gene is adjacent to an initiator methionine tRNA gene in soybean mitochondrial DNA .
16364291	0	methionine_sulfoxide	61,81	MSRA	95,99	methionine sulfoxide	MSRA	MESH:C013111	4482	Chemical	Gene	stress|nmod|START_ENTITY structure|nmod|stress reductase|nsubj|structure reductase|dobj|END_ENTITY	Gene structure , localization and role in oxidative stress of methionine_sulfoxide reductase A -LRB- MSRA -RRB- in the monkey retina .
18845237	0	methionine_sulfoxide	34,54	MSRA	68,72	methionine sulfoxide	MSRA	MESH:C013111	4482	Chemical	Gene	reductase|nsubj|START_ENTITY reductase|dobj|gene gene|appos|END_ENTITY	Retinoic_acid regulates the human methionine_sulfoxide reductase A -LRB- MSRA -RRB- gene via two distinct promoters .
19542914	0	methionine_sulfoxide	57,77	MSRA	89,93	methionine sulfoxide	MSRA	MESH:C013111	4482	Chemical	Gene	reductase|amod|START_ENTITY reductase|appos|END_ENTITY	Differential expression of the antioxidant repair enzyme methionine_sulfoxide reductase -LRB- MSRA and MSRB -RRB- in human skin .
10799493	0	methionine_sulfoxide	74,94	MsrA	106,110	methionine sulfoxide	MsrA	MESH:C013111	281312(Tax:9913)	Chemical	Gene	START_ENTITY|dobj|reductase reductase|appos|END_ENTITY	Identification and characterization of a putative active site for peptide methionine_sulfoxide reductase -LRB- MsrA -RRB- and its substrate stereospecificity .
14759519	0	methionine_sulfoxide	12,32	MsrA	45,49	methionine sulfoxide	MsrA	MESH:C013111	4482	Chemical	Gene	reductases|amod|START_ENTITY reductases|appos|END_ENTITY	The peptide methionine_sulfoxide reductases , MsrA and MsrB -LRB- hCBS-1 -RRB- , are downregulated during replicative senescence of human WI-38 fibroblasts .
17180746	0	methionine_sulfoxide	31,51	MsrA	64,68	methionine sulfoxide	MsrA	MESH:C013111	4482	Chemical	Gene	START_ENTITY|dobj|reductases reductases|appos|END_ENTITY	Molecular evolution of peptide methionine_sulfoxide reductases -LRB- MsrA and MsrB -RRB- : on the early development of a mechanism that protects against oxidative damage .
19461988	0	methionine_sulfoxide	149,169	MsrA	18,22	methionine sulfoxide	MsrA	MESH:C013111	110265(Tax:10090)	Chemical	Gene	A|amod|START_ENTITY role|nmod|A indicates|dobj|role results|parataxis|indicates results|nsubj|Deletion Deletion|nmod|END_ENTITY	Deletion of mouse MsrA results in HBO-induced cataract : MsrA repairs mitochondrial cytochrome c. PURPOSE : Considerable evidence indicates a role for methionine_sulfoxide reductase A -LRB- MsrA -RRB- in lens cell resistance to oxidative stress through its maintenance of mitochondrial function .
19461988	0	methionine_sulfoxide	149,169	MsrA	56,60	methionine sulfoxide	MsrA	MESH:C013111	110265(Tax:10090)	Chemical	Gene	A|amod|START_ENTITY role|nmod|A indicates|dobj|role results|parataxis|indicates results|parataxis|mitochondrial mitochondrial|nsubj|repairs repairs|compound|END_ENTITY	Deletion of mouse MsrA results in HBO-induced cataract : MsrA repairs mitochondrial cytochrome c. PURPOSE : Considerable evidence indicates a role for methionine_sulfoxide reductase A -LRB- MsrA -RRB- in lens cell resistance to oxidative stress through its maintenance of mitochondrial function .
22967951	0	methionine_sulfoxide	8,28	MsrA	42,46	methionine sulfoxide	MsrA	MESH:C013111	4482	Chemical	Gene	A|amod|START_ENTITY A|appos|END_ENTITY	Peptide methionine_sulfoxide reductase A -LRB- MsrA -RRB- : direct electrochemical oxidation on carbon electrodes .
18202432	0	methionine_sulfoxide	10,30	apoA-I	42,48	methionine sulfoxide	apoA-I	MESH:C013111	335	Chemical	Gene	content|amod|START_ENTITY content|nmod|END_ENTITY	Increased methionine_sulfoxide content of apoA-I in type 1 diabetes .
14980072	0	methionine_sulfoxide	15,35	hMSRB2	47,53	methionine sulfoxide	hMSRB2	MESH:C013111	22921	Chemical	Gene	reductase|compound|START_ENTITY reductase|appos|END_ENTITY	A second human methionine_sulfoxide reductase -LRB- hMSRB2 -RRB- reducing methionine-R-sulfoxide displays a tissue expression pattern distinct from hMSRB1 .
10452521	0	methionine_sulfoxide	63,83	hMsrA	95,100	methionine sulfoxide	hMsrA	MESH:C013111	4482	Chemical	Gene	reductase|compound|START_ENTITY reductase|appos|END_ENTITY	Molecular cloning and functional expression of a human peptide methionine_sulfoxide reductase -LRB- hMsrA -RRB- .
9927663	0	methionine_sulfoxide	51,71	msrA	28,32	methionine sulfoxide	msrA	MESH:C013111	4482	Chemical	Gene	reductase|compound|START_ENTITY encoding|dobj|reductase set|advcl|encoding set|dobj|END_ENTITY	The minimal gene set member msrA , encoding peptide methionine_sulfoxide reductase , is a virulence determinant of the plant pathogen Erwinia chrysanthemi .
9251105	0	methionine_sulfoximine	89,111	Ornithine_decarboxylase	0,23	methionine sulfoximine	Ornithine decarboxylase	MESH:D008717	24609(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY activity|dep|effect activity|amod|END_ENTITY	Ornithine_decarboxylase activity in cerebral post-ischemic reperfusion damage : effect of methionine_sulfoximine .
23303753	0	methionine_sulphoxide	57,78	ApoA-I	90,96	methionine sulphoxide	ApoA-I	null	335	Chemical	Gene	content|amod|START_ENTITY content|nmod|END_ENTITY	An effective and rapid determination by MALDI/TOF/TOF of methionine_sulphoxide content of ApoA-I in type 2 diabetic patients .
17907003	0	methionine_sulphoxide	64,85	MSRA	99,103	methionine sulphoxide	MSRA	null	29447(Tax:10116)	Chemical	Gene	A|amod|START_ENTITY A|appos|END_ENTITY	Identification of a new functional splice variant of the enzyme methionine_sulphoxide reductase A -LRB- MSRA -RRB- expressed in rat vascular smooth muscle cells .
12693988	0	methionine_sulphoxide	28,49	MsrA	63,67	methionine sulphoxide	MsrA	null	29447(Tax:10116)	Chemical	Gene	reductase|amod|START_ENTITY reductase|appos|END_ENTITY	Subcellular localization of methionine_sulphoxide reductase A -LRB- MsrA -RRB- : evidence for mitochondrial and cytosolic isoforms in rat liver cells .
24315858	0	methionines	134,145	alpha-synuclein	25,40	methionines	alpha-synuclein	null	6622	Chemical	Gene	Mechanism|nmod|START_ENTITY Mechanism|nmod|END_ENTITY	Mechanism of cleavage of alpha-synuclein by the 20S proteasome and modulation of its degradation by the RedOx state of the N-terminal methionines .
20519567	0	methionines	16,27	copper_transporter_1	84,104	methionines	copper transporter 1	null	1317	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	The role of the methionines and histidines in the transmembrane domain of mammalian copper_transporter_1 in the cellular accumulation of cisplatin .
22062075	0	methionyl	47,56	aminopeptidase	57,71	methionyl	aminopeptidase	CHEBI:37902	10404	Chemical	Gene	Purification|nmod|START_ENTITY END_ENTITY|nsubj|Purification	Purification and characterization of a soluble methionyl aminopeptidase from porcine skeletal muscle .
2022713	0	methionyl	45,54	growth_hormone	55,69	methionyl	growth hormone	CHEBI:37902	2688	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY END_ENTITY|nsubj|pharmacokinetics	Single and multiple dose pharmacokinetics of methionyl growth_hormone in children with idiopathic growth_hormone deficiency .
2571554	0	methionyl	23,32	growth_hormone	33,47	methionyl	growth hormone	CHEBI:37902	2688	Chemical	Gene	therapy|amod|START_ENTITY therapy|compound|END_ENTITY	Effect of biosynthetic methionyl growth_hormone -LRB- GH -RRB- therapy on the immune function in GH-deficient children .
2809902	0	methionyl	24,33	growth_hormone	34,48	methionyl	growth hormone	CHEBI:37902	2688	Chemical	Gene	therapy|amod|START_ENTITY therapy|compound|END_ENTITY	Effects of two years of methionyl growth_hormone therapy in two dosage regimens in prepubertal children with short_stature , subnormal growth rate , and normal growth_hormone response to secretagogues .
2479583	0	methionyl	72,81	insulin-like_growth_factor-I	82,110	methionyl	insulin-like growth factor-I	CHEBI:37902	3479	Chemical	Gene	variants|amod|START_ENTITY variants|compound|END_ENTITY	Binding protein , radioreceptor and biological activities of recombinant methionyl insulin-like_growth_factor-I variants .
16636130	0	methionyl	12,21	leptin	28,34	methionyl	leptin	CHEBI:37902	3952	Chemical	Gene	therapy|amod|START_ENTITY therapy|compound|END_ENTITY	Recombinant methionyl human leptin therapy in replacement doses improves insulin resistance and metabolic profile in patients with lipoatrophy and metabolic_syndrome induced by the highly active antiretroviral therapy .
15613409	0	methionyl	12,21	signal_transducer_and_activator_of_transcription_3	60,110	methionyl	signal transducer and activator of transcription 3	CHEBI:37902	6774	Chemical	Gene	START_ENTITY|ccomp|activates activates|dobj|END_ENTITY	Recombinant methionyl human leptin administration activates signal_transducer_and_activator_of_transcription_3 signaling in peripheral blood mononuclear cells in vivo and regulates soluble tumor_necrosis_factor-alpha_receptor levels in humans with relative leptin_deficiency .
23375192	0	methomyl	91,99	CD-1	103,107	methomyl	CD-1	MESH:D008724	111334(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|compound|END_ENTITY	Kidney antioxidant status , biochemical parameters and histopathological changes induced by methomyl in CD-1 mice .
22796246	0	methotrexate	68,80	ABCB1	0,5	methotrexate	ABCB1	MESH:D008727	5243	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY polymorphism|nmod|pharmacokinetics polymorphism|compound|END_ENTITY	ABCB1 C3435T genetic polymorphism on population pharmacokinetics of methotrexate after hematopoietic stem cell transplantation in Korean patients : a prospective analysis .
8358980	0	methotrexate	17,29	C-reactive_protein	33,51	methotrexate	C-reactive protein	MESH:D008727	1401	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Better effect of methotrexate on C-reactive_protein during daily compared to weekly treatment in rheumatoid_arthritis .
6190548	0	methotrexate	90,102	COB	78,81	methotrexate	COB	MESH:D008727	326625	Chemical	Gene	trial|nmod|START_ENTITY trial|appos|END_ENTITY	A randomized trial of the combination of cis-platinum , oncovin and bleomycin -LRB- COB -RRB- versus methotrexate in patients with advanced squamous_cell_carcinoma of the head_and_neck .
10880023	0	methotrexate	14,26	DHFR	86,90	methotrexate	DHFR	MESH:D008727	13361(Tax:10090)	Chemical	Gene	resistance|amod|START_ENTITY Comparison|nmod|resistance conferred|nsubj|Comparison conferred|nmod|cDNA cDNA|appos|END_ENTITY	Comparison of methotrexate resistance conferred by a mutated dihydrofolate_reductase -LRB- DHFR -RRB- cDNA in two different retroviral vectors .
12416030	0	methotrexate	144,156	DHFR	202,206	methotrexate	DHFR	MESH:D008727	1719	Chemical	Gene	sensitization|nmod|START_ENTITY alteration|appos|sensitization activity|dep|alteration activity|amod|END_ENTITY	Severe folate restriction results in depletion of and alteration in the composition of the intracellular folate pool , moderate sensitization to methotrexate and trimetrexate , upregulation of endogenous DHFR activity , and overexpression of metallothionein_II and folate receptor alpha that , upon folate repletion , confer drug resistance to CHL cells .
15142554	0	methotrexate	25,37	DHFR	75,79	methotrexate	DHFR	MESH:D008727	1719	Chemical	Gene	conjugates|nmod|START_ENTITY conjugates|nmod|inhibitors inhibitors|amod|END_ENTITY	Lipophilic conjugates of methotrexate with short-chain alkylamino_acids as DHFR inhibitors .
18385200	0	methotrexate	23,35	DHFR	99,103	methotrexate	DHFR	MESH:D008727	1719	Chemical	Gene	impact|nmod|START_ENTITY resistance-associated|nsubj|impact resistance-associated|dobj|genes genes|appos|END_ENTITY	Clinical impact of the methotrexate resistance-associated genes C-MYC and dihydrofolate_reductase -LRB- DHFR -RRB- in high-grade osteosarcoma .
22324981	0	methotrexate	84,96	DHFR	40,44	methotrexate	DHFR	MESH:D008727	1719	Chemical	Gene	-317|advcl|START_ENTITY -317|nsubj|Association Association|appos|END_ENTITY	Association of dihydrofolate_reductase -LRB- DHFR -RRB- -317 AA genotype with poor response to methotrexate in patients with rheumatoid_arthritis .
23581023	0	methotrexate	71,83	DHFR	32,36	methotrexate	DHFR	MESH:D008727	1719	Chemical	Gene	effects|nmod|START_ENTITY effects|amod|END_ENTITY	New mechanisms for an old drug ; DHFR - and non-DHFR-mediated effects of methotrexate in cancer cells .
23838799	0	methotrexate	147,159	DHFR	48,52	methotrexate	DHFR	MESH:D008727	1719	Chemical	Gene	doses|nmod|START_ENTITY Alterations|nmod|doses Alterations|nmod|pattern pattern|nmod|TYMS TYMS|appos|END_ENTITY	Alterations in the expression pattern of MTHFR , DHFR , TYMS , and SLC19A1 genes after treatment of laryngeal_cancer cells with high and low doses of methotrexate .
2824082	0	methotrexate	93,105	DHFR	0,4	methotrexate	DHFR	MESH:D008727	1719	Chemical	Gene	selection|amod|START_ENTITY amplification|nmod|selection amplification|amod|END_ENTITY	DHFR gene amplification in cultured skin fibroblasts of ataxia_telangiectasia patients after methotrexate selection .
7475310	0	methotrexate	24,36	DHFR	99,103	methotrexate	DHFR	MESH:D008727	1719	Chemical	Gene	START_ENTITY|nmod|transfer transfer|nmod|END_ENTITY	Increased resistance to methotrexate in human hematopoietic cells after gene transfer of the Ser31 DHFR mutant .
9357973	0	methotrexate	136,148	DHFR	55,59	methotrexate	DHFR	MESH:D008727	13361(Tax:10090)	Chemical	Gene	doses|nmod|START_ENTITY recipients|nmod|doses protection|nmod|recipients Transgenic_mice|dep|protection Transgenic_mice|acl|expressing expressing|dobj|variant variant|nmod|END_ENTITY	Transgenic_mice expressing the tyr22 variant of murine DHFR : protection of transgenic marrow transplant recipients from lethal doses of methotrexate .
12825924	0	methotrexate	62,74	Dihydrofolate_reductase	0,23	methotrexate	Dihydrofolate reductase	MESH:D008727	13361(Tax:10090)	Chemical	Gene	mutant|xcomp|START_ENTITY mutant|nsubj|END_ENTITY	Dihydrofolate_reductase mutant with exceptional resistance to methotrexate but not to trimetrexate .
17920	0	methotrexate	68,80	Dihydrofolate_reductase	0,23	methotrexate	Dihydrofolate reductase	MESH:D008727	1719	Chemical	Gene	complex|nmod|START_ENTITY structure|nmod|complex END_ENTITY|dep|structure	Dihydrofolate_reductase : x-ray structure of the binary complex with methotrexate .
9174938	0	methotrexate	65,77	Dihydrofolate_reductase	0,23	methotrexate	Dihydrofolate reductase	MESH:D008727	1719	Chemical	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	Dihydrofolate_reductase synthesis in the presence of immobilized methotrexate .
9931044	0	methotrexate	59,71	Dihydrofolate_reductase	0,23	methotrexate	Dihydrofolate reductase	MESH:D008727	1719	Chemical	Gene	determination|compound|START_ENTITY assay|nmod|determination enzyme|dobj|assay enzyme|nsubj|END_ENTITY	Dihydrofolate_reductase enzyme inhibition assay for plasma methotrexate determination using a 96-well microplate reader .
21224110	0	methotrexate	82,94	FAP	19,22	methotrexate	FAP	MESH:D008727	2191	Chemical	Gene	combined|nmod|START_ENTITY combined|nsubj|study study|nmod|END_ENTITY	A phase I study of FAP -LRB- 5-Fluorouracil , a-interferon and cisplatin -RRB- combined with methotrexate for the treatment of advanced urothelial_malignancies .
1704940	0	methotrexate	72,84	Granulocyte-colony_stimulating_factor	0,37	methotrexate	Granulocyte-colony stimulating factor	MESH:D008727	1440	Chemical	Gene	effects|nmod|START_ENTITY enhances|dobj|effects enhances|nsubj|END_ENTITY	Granulocyte-colony_stimulating_factor enhances the cytotoxic effects of methotrexate to bladder_cancer cells in vitro .
22133036	0	methotrexate	17,29	IL-12A	86,92	methotrexate	IL-12A	MESH:D008727	3592	Chemical	Gene	influence|nmod|START_ENTITY influence|nmod|END_ENTITY	The influence of methotrexate on the gene expression of the pro-inflammatory cytokine IL-12A in the therapy of rheumatoid_arthritis .
15240743	0	methotrexate	130,142	IL-15	0,5	methotrexate	IL-15	MESH:D008727	3600	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|dep|effect	IL-15 and the initiation of cell contact-dependent synovial fibroblast-T lymphocyte cross-talk in rheumatoid_arthritis : effect of methotrexate .
21659065	0	methotrexate	10,22	IL-22	42,47	methotrexate	IL-22	MESH:D008727	50616	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|nmod|END_ENTITY	Effect of methotrexate on serum levels of IL-22 in patients with psoriasis .
15670151	0	methotrexate	86,98	IMPDH2	14,20	methotrexate	IMPDH2	MESH:D008727	3615	Chemical	Gene	sensitivity|xcomp|START_ENTITY sensitivity|nsubj|Modulation Modulation|nmod|increases increases|compound|END_ENTITY	Modulation of IMPDH2 , survivin , topoisomerase_I and vimentin increases sensitivity to methotrexate in HT29 human colon_cancer cells .
16609701	0	methotrexate	53,65	IMPDH2	83,89	methotrexate	IMPDH2	MESH:D008727	3615	Chemical	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	ZNRD1 mediates resistance of gastric_cancer cells to methotrexate by regulation of IMPDH2 and Bcl-2 .
19648778	0	methotrexate	122,134	Interleukin-10	0,14	methotrexate	Interleukin-10	MESH:D008727	3586	Chemical	Gene	injected|xcomp|START_ENTITY injected|nsubj|END_ENTITY	Interleukin-10 and interleukin-6 in aqueous_humor during treatment of vitreoretinal_lymphoma with intravitreally injected methotrexate .
22546471	0	methotrexate	49,61	Interleukin-6	0,13	methotrexate	Interleukin-6	MESH:D008727	16193(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY regulates|dobj|effect regulates|nsubj|END_ENTITY	Interleukin-6 regulates anti-arthritic effect of methotrexate via reduction of SLC19A1 expression in a mouse arthritis model .
7738942	0	methotrexate	119,131	Interleukin_6	0,13	methotrexate	Interleukin 6	MESH:D008727	3569	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|END_ENTITY	Interleukin_6 -LRB- IL-6 -RRB- and soluble IL-2_receptor levels in patients with rheumatoid_arthritis treated with low dose oral methotrexate .
11375950	0	methotrexate	68,80	LST-2	0,5	methotrexate	LST-2	MESH:D008727	28234	Chemical	Gene	sensitivity|amod|START_ENTITY determines|dobj|sensitivity determines|nsubj|END_ENTITY	LST-2 , a human liver-specific organic anion transporter , determines methotrexate sensitivity in gastrointestinal_cancers .
16483740	0	methotrexate	63,75	NF-kappaB	15,24	methotrexate	NF-kappaB	MESH:D008727	18033(Tax:10090)	Chemical	Gene	Involvement|acl|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of NF-kappaB in the response of embryonic cells to methotrexate .
15972692	0	methotrexate	58,70	NURR1	38,43	methotrexate	NURR1	MESH:D008727	4929	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|expression expression|compound|END_ENTITY	Modulation of orphan nuclear receptor NURR1 expression by methotrexate in human inflammatory_joint_disease involves adenosine_A2A_receptor-mediated responses .
23243220	0	methotrexate	76,88	OATP1B1	19,26	methotrexate	OATP1B1	MESH:D008727	10599	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY Influence|nmod|pharmacokinetics Influence|nmod|END_ENTITY	Influence of human OATP1B1 , OATP1B3 , and OATP1A2 on the pharmacokinetics of methotrexate and paclitaxel in humanized transgenic_mice .
18578967	0	methotrexate	40,52	Tumor_necrosis_factor_alpha	0,27	methotrexate	Tumor necrosis factor alpha	MESH:D008727	7124	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Tumor_necrosis_factor_alpha inhibitors , methotrexate or both ?
16609701	0	methotrexate	53,65	ZNRD1	0,5	methotrexate	ZNRD1	MESH:D008727	30834	Chemical	Gene	mediates|xcomp|START_ENTITY mediates|nsubj|END_ENTITY	ZNRD1 mediates resistance of gastric_cancer cells to methotrexate by regulation of IMPDH2 and Bcl-2 .
6966221	0	methotrexate	47,59	albumin	28,35	methotrexate	albumin	MESH:D008727	213	Chemical	Gene	Modification|nmod|START_ENTITY Modification|nmod|END_ENTITY	Modification of human serum albumin binding of methotrexate by folinic_acid and certain drugs used in cancer chemotherapy .
24018427	0	methotrexate	100,112	allograft_inflammatory_factor-1	10,41	methotrexate	allograft inflammatory factor-1	MESH:D008727	199	Chemical	Gene	polymorphisms|nmod|START_ENTITY polymorphisms|nsubj|Effect Effect|nmod|gene gene|amod|END_ENTITY	Effect of allograft_inflammatory_factor-1 gene polymorphisms on rheumatoid_arthritis treatment with methotrexate .
18694510	0	methotrexate	72,84	caveolin_1	8,18	methotrexate	caveolin 1	MESH:D008727	857	Chemical	Gene	Role|acl|START_ENTITY Role|nmod|END_ENTITY	Role of caveolin_1 , E-cadherin , Enolase 2 and PKCalpha on resistance to methotrexate in human HT29 colon_cancer cells .
2122527	0	methotrexate	19,31	dhfr	50,54	methotrexate	dhfr	MESH:D008727	13361(Tax:10090)	Chemical	Gene	resistance|amod|START_ENTITY induction|nmod|resistance induction|amod|due due|nmod|amplification amplification|compound|END_ENTITY	X-ray induction of methotrexate resistance due to dhfr gene amplification .
10063803	0	methotrexate	29,41	dihydrofolate_reductase	96,119	methotrexate	dihydrofolate reductase	MESH:D008727	13906554	Chemical	Gene	reduction|nmod|START_ENTITY activates|dobj|reduction activates|nmod|NADPH NADPH|nmod|END_ENTITY	Light activates reduction of methotrexate by NADPH in the ternary complex with Escherichia_coli dihydrofolate_reductase .
10481745	0	methotrexate	97,109	dihydrofolate_reductase	27,50	methotrexate	dihydrofolate reductase	MESH:D008727	1719	Chemical	Gene	activity|nmod|START_ENTITY abolishes|dobj|activity abolishes|nsubj|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of cellular dihydrofolate_reductase abolishes the anticytomegaloviral activity of methotrexate .
10801470	0	methotrexate	90,102	dihydrofolate_reductase	35,58	methotrexate	dihydrofolate reductase	MESH:D008727	13906554	Chemical	Gene	dimer|nmod|START_ENTITY induced|nmod|dimer induced|dobj|dimerization dimerization|nmod|END_ENTITY	Chemically induced dimerization of dihydrofolate_reductase by a homobifunctional dimer of methotrexate .
10810448	0	methotrexate	28,40	dihydrofolate_reductase	104,127	methotrexate	dihydrofolate reductase	MESH:D008727	1719	Chemical	Gene	START_ENTITY|dobj|toxicity toxicity|nmod|cells cells|acl|expressing expressing|dobj|activities activities|compound|END_ENTITY	Maintenance of differential methotrexate toxicity between cells expressing drug-resistant and wild-type dihydrofolate_reductase activities in the presence of nucleosides through nucleoside transport inhibition .
10880023	0	methotrexate	14,26	dihydrofolate_reductase	61,84	methotrexate	dihydrofolate reductase	MESH:D008727	13361(Tax:10090)	Chemical	Gene	resistance|amod|START_ENTITY Comparison|nmod|resistance conferred|nsubj|Comparison conferred|nmod|cDNA cDNA|amod|END_ENTITY	Comparison of methotrexate resistance conferred by a mutated dihydrofolate_reductase -LRB- DHFR -RRB- cDNA in two different retroviral vectors .
10942375	0	methotrexate	54,66	dihydrofolate_reductase	137,160	methotrexate	dihydrofolate reductase	MESH:D008727	13361(Tax:10090)	Chemical	Gene	resistance|amod|START_ENTITY confer|dobj|resistance confer|nmod|mice mice|dep|expressing expressing|dobj|activity activity|compound|END_ENTITY	Mild preconditioning and low-level engraftment confer methotrexate resistance in mice transplanted with marrow expressing drug-resistant dihydrofolate_reductase activity .
11001289	0	methotrexate	85,97	dihydrofolate_reductase	33,56	methotrexate	dihydrofolate reductase	MESH:D008727	1719	Chemical	Gene	presence|nmod|START_ENTITY analysis|nmod|presence analysis|nmod|reaction reaction|amod|END_ENTITY	Isotachophoretic analysis of the dihydrofolate_reductase reaction in the presence of methotrexate and ascorbic_acid .
11052790	0	methotrexate	115,127	dihydrofolate_reductase	51,74	methotrexate	dihydrofolate reductase	MESH:D008727	1719	Chemical	Gene	analogues|amod|START_ENTITY evaluation|nmod|analogues predictions|dep|evaluation predictions|acl|END_ENTITY	Computational predictions of binding affinities to dihydrofolate_reductase : synthesis and biological evaluation of methotrexate analogues .
12897877	0	methotrexate	70,82	dihydrofolate_reductase	38,61	methotrexate	dihydrofolate reductase	MESH:D008727	42003(Tax:7227)	Chemical	Gene	resistance|amod|START_ENTITY confers|dobj|resistance confers|nsubj|mutation mutation|nmod|END_ENTITY	A single point mutation in Drosophila dihydrofolate_reductase confers methotrexate resistance to a transgenic CHO cell line .
1426244	0	methotrexate	85,97	dihydrofolate_reductase	49,72	methotrexate	dihydrofolate reductase	MESH:D008727	13906554	Chemical	Gene	formed|nmod|START_ENTITY formed|nsubj|studies studies|nmod|complexes complexes|nmod|END_ENTITY	13C NMR studies of complexes of Escherichia_coli dihydrofolate_reductase formed with methotrexate and with folic_acid .
14662327	0	methotrexate	26,38	dihydrofolate_reductase	129,152	methotrexate	dihydrofolate reductase	MESH:D008727	1719	Chemical	Gene	toxicity|amod|START_ENTITY protection|nmod|toxicity protection|nmod|transfer transfer|nmod|mutants mutants|amod|END_ENTITY	Efficient protection from methotrexate toxicity and selection of transduced human hematopoietic cells following gene transfer of dihydrofolate_reductase mutants .
14679136	0	methotrexate	90,102	dihydrofolate_reductase	12,35	methotrexate	dihydrofolate reductase	MESH:D008727	1719	Chemical	Gene	Analysis|acl|START_ENTITY Analysis|nmod|status status|compound|END_ENTITY	Analysis of dihydrofolate_reductase and reduced_folate_carrier gene status in relation to methotrexate resistance in osteosarcoma cells .
17130456	0	methotrexate	87,99	dihydrofolate_reductase	48,71	methotrexate	dihydrofolate reductase	MESH:D008727	13906554	Chemical	Gene	complexed|nmod|START_ENTITY complexed|nsubj|studies studies|nmod|END_ENTITY	Neutron diffraction studies of Escherichia_coli dihydrofolate_reductase complexed with methotrexate .
17586722	0	methotrexate	24,36	dihydrofolate_reductase	121,144	methotrexate	dihydrofolate reductase	MESH:D008727	13361(Tax:10090)	Chemical	Gene	toxicity|amod|START_ENTITY mice|nmod|toxicity Protection|nmod|mice vectors|nsubj|Protection vectors|xcomp|expressing expressing|dobj|END_ENTITY	Protection of mice from methotrexate toxicity by ex vivo transduction using lentivirus vectors expressing drug-resistant dihydrofolate_reductase .
17686970	0	methotrexate	85,97	dihydrofolate_reductase	47,70	methotrexate	dihydrofolate reductase	MESH:D008727	1719	Chemical	Gene	leads|xcomp|START_ENTITY leads|nsubj|polymorphism polymorphism|nmod|gene gene|amod|END_ENTITY	A miR-24 microRNA binding-site polymorphism in dihydrofolate_reductase gene leads to methotrexate resistance .
17868689	0	methotrexate	11,23	dihydrofolate_reductase	84,107	methotrexate	dihydrofolate reductase	MESH:D008727	1719	Chemical	Gene	resistance|amod|START_ENTITY resistance|nmod|combination combination|nmod|mutations mutations|nmod|END_ENTITY	Increasing methotrexate resistance by combination of active-site mutations in human dihydrofolate_reductase .
19337845	0	methotrexate	14,26	dihydrofolate_reductase	78,101	methotrexate	dihydrofolate reductase	MESH:D008727	42003(Tax:7227)	Chemical	Gene	resistance|amod|START_ENTITY resistance|nmod|cells cells|acl|bearing bearing|dobj|transgene transgene|compound|END_ENTITY	Selection for methotrexate resistance in mammalian cells bearing a Drosophila dihydrofolate_reductase transgene : Methotrexate resistance in transgenic mammalian cells .
19478082	0	methotrexate	121,133	dihydrofolate_reductase	44,67	methotrexate	dihydrofolate reductase	MESH:D008727	1719	Chemical	Gene	resistance|amod|START_ENTITY basis|nmod|resistance suggest|dobj|basis suggest|nsubj|conformers conformers|nmod|site site|nmod|mutant mutant|compound|END_ENTITY	Multiple conformers in active site of human dihydrofolate_reductase F31R/Q35E double mutant suggest structural basis for methotrexate resistance .
1998678	0	methotrexate	56,68	dihydrofolate_reductase	80,103	methotrexate	dihydrofolate reductase	MESH:D008727	13906554	Chemical	Gene	complex|amod|START_ENTITY complex|nmod|END_ENTITY	Evidence for two interconverting protein isomers in the methotrexate complex of dihydrofolate_reductase from Escherichia_coli .
21360609	0	methotrexate	32,44	dihydrofolate_reductase	54,77	methotrexate	dihydrofolate reductase	MESH:D008727	1719	Chemical	Gene	binding|nmod|START_ENTITY weakened|xcomp|binding weakened|nmod|END_ENTITY	Selectively weakened binding of methotrexate by human dihydrofolate_reductase allows rapid ex vivo selection of mammalian cells .
21987253	0	methotrexate	39,51	dihydrofolate_reductase	82,105	methotrexate	dihydrofolate reductase	MESH:D008727	13361(Tax:10090)	Chemical	Gene	amplification|amod|START_ENTITY Generation|nmod|amplification Generation|nmod|marker marker|compound|END_ENTITY	Generation of high-expressing cells by methotrexate amplification of destabilized dihydrofolate_reductase selection marker .
22324981	0	methotrexate	84,96	dihydrofolate_reductase	15,38	methotrexate	dihydrofolate reductase	MESH:D008727	1719	Chemical	Gene	-317|advcl|START_ENTITY -317|nsubj|Association Association|nmod|END_ENTITY	Association of dihydrofolate_reductase -LRB- DHFR -RRB- -317 AA genotype with poor response to methotrexate in patients with rheumatoid_arthritis .
22994778	0	methotrexate	122,134	dihydrofolate_reductase	37,60	methotrexate	dihydrofolate reductase	MESH:D008727	1719	Chemical	Gene	START_ENTITY|nsubj|Association Association|nmod|polymorphisms polymorphisms|nmod|genes genes|amod|END_ENTITY	Association between polymorphisms of dihydrofolate_reductase and gamma_glutamyl hydrolase genes and toxicity of high dose methotrexate in children with acute_lymphoblastic_leukemia .
23267138	0	methotrexate	98,110	dihydrofolate_reductase	38,61	methotrexate	dihydrofolate reductase	MESH:D008727	1719	Chemical	Gene	effects|nmod|START_ENTITY effects|amod|END_ENTITY	Interaction between Gambogic_acid and dihydrofolate_reductase and synergistic lethal effects with methotrexate on hepatoma cells .
2328265	0	methotrexate	64,76	dihydrofolate_reductase	21,44	methotrexate	dihydrofolate reductase	MESH:D008727	508809(Tax:9913)	Chemical	Gene	sensitivity|amod|START_ENTITY Inhibition|nmod|sensitivity Inhibition|nmod|END_ENTITY	Inhibition of bovine dihydrofolate_reductase and enhancement of methotrexate sensitivity by N4 - -LRB- 2-acetoxyethoxymethyl -RRB- -2 - acetylpyridine_thiosemicarbazone .
2448654	0	methotrexate	204,216	dihydrofolate_reductase	112,135	methotrexate	dihydrofolate reductase	MESH:D008727	1719	Chemical	Gene	biosynthesis|nmod|START_ENTITY utilization|nmod|biosynthesis utilization|compound|END_ENTITY	Biochemical factors in the selectivity of leucovorin rescue : selective inhibition of leucovorin reactivation of dihydrofolate_reductase and leucovorin utilization in purine and pyrimidine biosynthesis by methotrexate and dihydrofolate_polyglutamates .
2914962	0	methotrexate	107,119	dihydrofolate_reductase	31,54	methotrexate	dihydrofolate reductase	MESH:D008727	1719	Chemical	Gene	binding|xcomp|START_ENTITY decreased|xcomp|binding decreased|nsubj|Amplification Amplification|nmod|gene gene|compound|END_ENTITY	Amplification of a polymorphic dihydrofolate_reductase gene expressing an enzyme with decreased binding to methotrexate in a human colon_carcinoma cell line , HCT-8R4 , resistant to this drug .
3152912	0	methotrexate	32,44	dihydrofolate_reductase	48,71	methotrexate	dihydrofolate reductase	MESH:D008727	1719	Chemical	Gene	doses|nmod|START_ENTITY Action|nmod|doses Action|nmod|END_ENTITY	Action of intermediate doses of methotrexate on dihydrofolate_reductase in malignant_diseases .
3200837	0	methotrexate	51,63	dihydrofolate_reductase	78,101	methotrexate	dihydrofolate reductase	MESH:D008727	1719	Chemical	Gene	START_ENTITY|nmod|mutants mutants|nmod|END_ENTITY	A free-energy perturbation study of the binding of methotrexate to mutants of dihydrofolate_reductase .
3292526	0	methotrexate	47,59	dihydrofolate_reductase	91,114	methotrexate	dihydrofolate reductase	MESH:D008727	1719	Chemical	Gene	complexes|amod|START_ENTITY formation|nmod|complexes Kinetics|nmod|formation Kinetics|nmod|END_ENTITY	Kinetics of the formation and isomerization of methotrexate complexes of recombinant human dihydrofolate_reductase .
3467329	0	methotrexate	23,35	dihydrofolate_reductase	73,96	methotrexate	dihydrofolate reductase	MESH:D008727	13361(Tax:10090)	Chemical	Gene	resistance|acl|START_ENTITY transgenic_mice|nsubj|resistance transgenic_mice|xcomp|carrying carrying|dobj|gene gene|compound|END_ENTITY	Systemic resistance to methotrexate in transgenic_mice carrying a mutant dihydrofolate_reductase gene .
3468634	0	methotrexate	57,69	dihydrofolate_reductase	20,43	methotrexate	dihydrofolate reductase	MESH:D008727	13361(Tax:10090)	Chemical	Gene	resistance|amod|START_ENTITY confers|dobj|resistance confers|nsubj|Expression Expression|nmod|gene gene|compound|END_ENTITY	Expression of mouse dihydrofolate_reductase gene confers methotrexate resistance in transgenic petunia plants .
3580007	0	methotrexate	128,140	dihydrofolate_reductase	12,35	methotrexate	dihydrofolate reductase	MESH:D008727	1719	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|Increase Increase|nmod|patients patients|amod|END_ENTITY	Increase of dihydrofolate_reductase in peripheral blood lymphocytes of rheumatoid_arthritis patients treated with low-dose oral methotrexate .
3692154	0	methotrexate	95,107	dihydrofolate_reductase	17,40	methotrexate	dihydrofolate reductase	MESH:D008727	100689028	Chemical	Gene	-RSB-|amod|START_ENTITY resistant|nmod|-RSB- amplified|xcomp|resistant amplified|nsubj|Localization Localization|nmod|END_ENTITY	-LSB- Localization of dihydrofolate_reductase amplified genes in Chinese_hamster cells resistant to methotrexate -RSB- .
3700393	0	methotrexate	12,24	dihydrofolate_reductase	97,120	methotrexate	dihydrofolate reductase	MESH:D008727	1719	Chemical	Gene	labeling|nsubj|START_ENTITY labeling|xcomp|containing containing|dobj|levels levels|nmod|END_ENTITY	Fluorescent methotrexate labeling and flow cytometric analysis of cells containing low levels of dihydrofolate_reductase .
3964298	0	methotrexate	61,73	dihydrofolate_reductase	85,108	methotrexate	dihydrofolate reductase	MESH:D008727	1719	Chemical	Gene	assay|nmod|START_ENTITY re-evaluation|nmod|assay binding|nsubj|re-evaluation binding|xcomp|END_ENTITY	A re-evaluation of the competitive protein binding assay for methotrexate binding to dihydrofolate_reductase .
4016793	0	methotrexate	174,186	dihydrofolate_reductase	214,237	methotrexate	dihydrofolate reductase	MESH:D008727	1719	Chemical	Gene	therapy|nmod|START_ENTITY receiving|dobj|therapy receiving|nmod|protein protein|acl:relcl|END_ENTITY	High-performance liquid chromatographic and enzyme-inhibition assays of methotrexate concentrations in serum from patients receiving high-dose therapy : tight binding of some methotrexate to a protein that could be dihydrofolate_reductase .
4016793	0	methotrexate	72,84	dihydrofolate_reductase	214,237	methotrexate	dihydrofolate reductase	MESH:D008727	1719	Chemical	Gene	concentrations|amod|START_ENTITY assays|nmod|concentrations assays|nmod|patients patients|acl|receiving receiving|nmod|protein protein|acl:relcl|END_ENTITY	High-performance liquid chromatographic and enzyme-inhibition assays of methotrexate concentrations in serum from patients receiving high-dose therapy : tight binding of some methotrexate to a protein that could be dihydrofolate_reductase .
4230391	0	methotrexate	91,103	dihydrofolate_reductase	12,35	methotrexate	dihydrofolate reductase	MESH:D008727	1719	Chemical	Gene	Increase|xcomp|START_ENTITY Increase|nmod|activity activity|amod|END_ENTITY	Increase of dihydrofolate_reductase activity in cultured mammalian cells after exposure to methotrexate .
6189586	0	methotrexate	8,20	dihydrofolate_reductase	111,134	methotrexate	dihydrofolate reductase	MESH:D008727	1719	Chemical	Gene	polyglutamylation|amod|START_ENTITY Role|nmod|polyglutamylation binding|nsubj|Role binding|xcomp|END_ENTITY	Role of methotrexate polyglutamylation and cellular energy metabolism in inhibition of methotrexate binding to dihydrofolate_reductase by 5-formyltetrahydrofolate in Ehrlich_ascites_tumor cells in vitro .
6189586	0	methotrexate	87,99	dihydrofolate_reductase	111,134	methotrexate	dihydrofolate reductase	MESH:D008727	1719	Chemical	Gene	inhibition|nmod|START_ENTITY polyglutamylation|nmod|inhibition Role|nmod|polyglutamylation binding|nsubj|Role binding|xcomp|END_ENTITY	Role of methotrexate polyglutamylation and cellular energy metabolism in inhibition of methotrexate binding to dihydrofolate_reductase by 5-formyltetrahydrofolate in Ehrlich_ascites_tumor cells in vitro .
6262811	0	methotrexate	39,51	dihydrofolate_reductase	113,136	methotrexate	dihydrofolate reductase	MESH:D008727	13361(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|plasmid plasmid|acl|expressing expressing|dobj|END_ENTITY	Transformation of mouse fibroblasts to methotrexate resistance by a recombinant plasmid expressing a prokaryotic dihydrofolate_reductase .
6328427	0	methotrexate	112,124	dihydrofolate_reductase	24,47	methotrexate	dihydrofolate reductase	MESH:D008727	13361(Tax:10090)	Chemical	Gene	resistant|amod|START_ENTITY enzymes|amod|resistant coding|nmod|enzymes cDNAs|acl|coding select|dobj|cDNAs system|acl|select Expression|dep|system Expression|nmod|cDNA cDNA|compound|END_ENTITY	Expression of the mouse dihydrofolate_reductase cDNA in B. _ subtilis : a system to select mutant cDNAs coding for methotrexate resistant enzymes .
6402009	0	methotrexate	25,37	dihydrofolate_reductase	77,100	methotrexate	dihydrofolate reductase	MESH:D008727	427317(Tax:9031)	Chemical	Gene	analogues|nmod|START_ENTITY analogues|dep|characterization characterization|nmod|END_ENTITY	Fluorescent analogues of methotrexate : characterization and interaction with dihydrofolate_reductase .
6416176	0	methotrexate	20,32	dihydrofolate_reductase	75,98	methotrexate	dihydrofolate reductase	MESH:D008727	508809(Tax:9913)	Chemical	Gene	START_ENTITY|acl|bound bound|xcomp|END_ENTITY	Protonated state of methotrexate , trimethoprim , and pyrimethamine bound to dihydrofolate_reductase .
6585550	2	methotrexate	130,142	dihydrofolate_reductase	77,100	methotrexate	dihydrofolate reductase	MESH:D008727	1719	Chemical	Gene	monoesters|amod|START_ENTITY affinity|nmod|monoesters affinity|amod|END_ENTITY	Divergent influence of alkyl chain length on the dihydrofolate_reductase affinity and cytotoxicity of methotrexate monoesters .
6661412	0	methotrexate	115,127	dihydrofolate_reductase	34,57	methotrexate	dihydrofolate reductase	MESH:D008727	1719	Chemical	Gene	Amplification|amod|START_ENTITY Amplification|nmod|genes genes|amod|END_ENTITY	Amplification and organization of dihydrofolate_reductase genes in a human leukemic cell line , K-562 , resistant to methotrexate .
6738530	0	methotrexate	25,37	dihydrofolate_reductase	74,97	methotrexate	dihydrofolate reductase	MESH:D008727	13361(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|resistance resistance|nmod|gene gene|amod|END_ENTITY	UV radiation facilitates methotrexate resistance and amplification of the dihydrofolate_reductase gene in cultured 3T6 mouse cells .
6969180	0	methotrexate	44,56	dihydrofolate_reductase	138,161	methotrexate	dihydrofolate reductase	MESH:D008727	13361(Tax:10090)	Chemical	Gene	effectiveness|nmod|START_ENTITY effectiveness|acl|overcome overcome|nmod|elevations elevations|nmod|END_ENTITY	Limited effectiveness of in vitro high-dose methotrexate and leucovorin to overcome resistance in L1210 leukemia cells with elevations of dihydrofolate_reductase .
7053272	0	methotrexate	26,38	dihydrofolate_reductase	69,92	methotrexate	dihydrofolate reductase	MESH:D008727	24312(Tax:10116)	Chemical	Gene	toxicity|amod|START_ENTITY toxicity|nmod|END_ENTITY	Effect of malnutrition on methotrexate toxicity and tissue levels of dihydrofolate_reductase in the rat .
7069726	0	methotrexate	34,46	dihydrofolate_reductase	64,87	methotrexate	dihydrofolate reductase	MESH:D008727	1719	Chemical	Gene	analogues|nmod|START_ENTITY analogues|nmod|inhibitors inhibitors|nmod|END_ENTITY	Lysine and ornithine analogues of methotrexate as inhibitors of dihydrofolate_reductase .
7099148	0	methotrexate	10,22	dihydrofolate_reductase	26,49	methotrexate	dihydrofolate reductase	MESH:D008727	1719	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	Effect of methotrexate on dihydrofolate_reductase activity in methotrexate-resistant human KB cells .
7391066	2	methotrexate	439,451	dihydrofolate_reductase	541,564	methotrexate	dihydrofolate reductase	MESH:D008727	100689028	Chemical	Gene	sensitive|nmod|START_ENTITY fibroblasts|amod|sensitive line|nmod|fibroblasts numbers|nmod|line quantification|nmod|numbers quantification|acl:relcl|cross-resistant cross-resistant|nmod|virtue virtue|nmod|overproduction overproduction|nmod|END_ENTITY	Purification of a cDNA probe specific for dihydrofolate_reductase mRNA has allowed the relative quantification of dihydrofolate_reductase gene numbers and mRNA levels between a line of Chinese_hamster lung fibroblasts sensitive to the antifolate drugs methotrexate and methasquin and sublines which by virtue of their overproduction of the target enzyme dihydrofolate_reductase are cross-resistant to these site-specific inhibitors .
7605998	0	methotrexate	91,103	dihydrofolate_reductase	21,44	methotrexate	dihydrofolate reductase	MESH:D008727	1719	Chemical	Gene	mechanism|acl|START_ENTITY mechanism|nsubj|Amplification Amplification|nmod|gene gene|amod|END_ENTITY	Amplification of the dihydrofolate_reductase gene is a mechanism of acquired resistance to methotrexate in patients with acute_lymphoblastic_leukemia and is correlated with p53 gene mutations .
7621235	0	methotrexate	60,72	dihydrofolate_reductase	149,172	methotrexate	dihydrofolate reductase	MESH:D008727	13361(Tax:10090)	Chemical	Gene	doses|nmod|START_ENTITY mice|nmod|doses protection|nmod|mice retrovirus|nsubj|protection retrovirus|xcomp|containing containing|dobj|END_ENTITY	Long-term protection of recipient mice from lethal doses of methotrexate by marrow infected with a double-copy vector retrovirus containing a mutant dihydrofolate_reductase .
7707376	0	methotrexate	97,109	dihydrofolate_reductase	68,91	methotrexate	dihydrofolate reductase	MESH:D008727	1719	Chemical	Gene	bound|nmod|START_ENTITY bound|nmod|complexes complexes|nmod|END_ENTITY	Detection of long-lived bound water molecules in complexes of human dihydrofolate_reductase with methotrexate and NADPH .
7707377	0	methotrexate	147,159	dihydrofolate_reductase	118,141	methotrexate	dihydrofolate reductase	MESH:D008727	1719	Chemical	Gene	Contributions|nmod|START_ENTITY Contributions|nmod|END_ENTITY	Contributions of tryptophan 24 and glutamate 30 to binding long-lived water molecules in the ternary complex of human dihydrofolate_reductase with methotrexate and NADPH studied by site-directed mutagenesis and nuclear magnetic resonance spectroscopy .
8642859	0	methotrexate	136,148	dihydrofolate_reductase	32,55	methotrexate	dihydrofolate reductase	MESH:D008727	1719	Chemical	Gene	therapy|nmod|START_ENTITY pediatric_leukemia|nmod|therapy relapse|nmod|pediatric_leukemia cause|nmod|relapse Mutations|dep|cause Mutations|nmod|gene gene|nmod|END_ENTITY	Mutations in the gene for human dihydrofolate_reductase : an unlikely cause of clinical relapse in pediatric_leukemia after therapy with methotrexate .
9012448	0	methotrexate	143,155	dihydrofolate_reductase	64,87	methotrexate	dihydrofolate reductase	MESH:D008727	1719	Chemical	Gene	resistance|amod|START_ENTITY comparison|nmod|resistance transfer|dep|comparison transfer|nmod|K562 K562|amod|END_ENTITY	Retrovirally mediated gene transfer of Arg22 and Tyr22 forms of dihydrofolate_reductase into the hematopoietic cell line K562 : a comparison of methotrexate resistance .
9195212	0	methotrexate	16,28	dihydrofolate_reductase	161,184	methotrexate	dihydrofolate reductase	MESH:D008727	1719	Chemical	Gene	administration|compound|START_ENTITY leads|nsubj|administration leads|nmod|curability curability|nmod|mice mice|acl|bearing bearing|nmod|marrow marrow|acl|transduced transduced|nmod|cDNA cDNA|compound|END_ENTITY	Post-transplant methotrexate administration leads to improved curability of mice bearing a mammary_tumor transplanted with marrow transduced with a mutant human dihydrofolate_reductase cDNA .
9231073	0	methotrexate	76,88	dihydrofolate_reductase	135,158	methotrexate	dihydrofolate reductase	MESH:D008727	1719	Chemical	Gene	START_ENTITY|ccomp|conferred conferred|nmod|transfer transfer|nmod|gene gene|compound|END_ENTITY	Co-expression of the herpes simplex virus thymidine kinase gene potentiates methotrexate resistance conferred by transfer of a mutated dihydrofolate_reductase gene .
9554740	0	methotrexate	72,84	dihydrofolate_reductase	22,45	methotrexate	dihydrofolate reductase	MESH:D008727	1719	Chemical	Gene	confer|advcl|START_ENTITY confer|nmod|mutations mutations|nmod|END_ENTITY	In vitro mutations in dihydrofolate_reductase that confer resistance to methotrexate : potential for clinical application .
9622097	0	methotrexate	88,100	dihydrofolate_reductase	147,170	methotrexate	dihydrofolate reductase	MESH:D008727	13361(Tax:10090)	Chemical	Gene	resistance|amod|START_ENTITY conferred|nsubj|resistance conferred|nmod|transfer transfer|nmod|gene gene|compound|END_ENTITY	Purine salvage rescue by xanthine-guanine phosphoribosyltransferase -LRB- XGPRT -RRB- potentiates methotrexate resistance conferred by transfer of a mutated dihydrofolate_reductase gene .
9724337	0	methotrexate	118,130	dihydrofolate_reductase	31,54	methotrexate	dihydrofolate reductase	MESH:D008727	13361(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY protects|nmod|effects protects|nsubj|form form|nmod|END_ENTITY	Methotrexate-resistant form of dihydrofolate_reductase protects transgenic murine embryos from teratogenic effects of methotrexate .
9796971	0	methotrexate	20,32	dihydrofolate_reductase	71,94	methotrexate	dihydrofolate reductase	MESH:D008727	1719	Chemical	Gene	activity|nmod|START_ENTITY Ex|dobj|activity Ex|nmod|inhibitors inhibitors|nmod|END_ENTITY	Ex vivo activity of methotrexate versus novel antifolate inhibitors of dihydrofolate_reductase and thymidylate_synthase against childhood_leukemia cells .
8408021	2	methotrexate	119,131	folylpoly-gamma-glutamate_synthetase	79,115	methotrexate	folylpoly-gamma-glutamate synthetase	MESH:D008727	2356	Chemical	Gene	metabolism|amod|START_ENTITY Role|nmod|metabolism Role|nmod|END_ENTITY	Role of folylpoly-gamma-glutamate_synthetase in methotrexate metabolism and cytotoxicity .
11389096	0	methotrexate	57,69	gamma-Glutamyl_hydrolase	29,53	methotrexate	gamma-Glutamyl hydrolase	MESH:D008727	8836	Chemical	Gene	metabolism|amod|START_ENTITY Effects|nmod|metabolism Effects|nmod|END_ENTITY	Effects of overexpression of gamma-Glutamyl_hydrolase on methotrexate metabolism and resistance .
9306433	0	methotrexate	99,111	gamma-Glutamyl_hydrolase	0,24	methotrexate	gamma-Glutamyl hydrolase	MESH:D008727	8836	Chemical	Gene	polyglutamylation|nmod|START_ENTITY predict|dobj|polyglutamylation predict|nsubj|activities activities|amod|END_ENTITY	gamma-Glutamyl_hydrolase and folylpolyglutamate_synthetase activities predict polyglutamylation of methotrexate in acute_leukemias .
9080326	0	methotrexate	29,41	gamma-glutamyl_hydrolase	94,118	methotrexate	gamma-glutamyl hydrolase	MESH:D008727	8836	Chemical	Gene	polyglutamates|amod|START_ENTITY electrophoresis|nmod|polyglutamates electrophoresis|nmod|activity activity|amod|END_ENTITY	Capillary electrophoresis of methotrexate polyglutamates and its application in evaluation of gamma-glutamyl_hydrolase activity .
19260847	0	methotrexate	62,74	growth_hormone	10,24	methotrexate	growth hormone	MESH:D008727	81668(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Effect Effect|nmod|END_ENTITY	Effect of growth_hormone on testicular_dysfunction induced by methotrexate in rats .
23750271	0	methotrexate	23,35	interleukin-10	53,67	methotrexate	interleukin-10	MESH:D008727	3586	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|amod|END_ENTITY	Effect of intravitreal methotrexate and rituximab on interleukin-10 levels in aqueous_humor_of_treated_eyes with vitreoretinal_lymphoma .
22609260	0	methotrexate	42,54	interleukin-6	6,19	methotrexate	interleukin-6	MESH:D008727	3569	Chemical	Gene	Serum|advcl|START_ENTITY Serum|dobj|levels levels|amod|END_ENTITY	Serum interleukin-6 levels in response to methotrexate treatment in psoriatic patients .
7914751	0	methotrexate	49,61	interleukin-6	100,113	methotrexate	interleukin-6	MESH:D008727	3569	Chemical	Gene	START_ENTITY|nmod|measurements measurements|nmod|bioactivity bioactivity|amod|END_ENTITY	Interference of circulating azathioprine but not methotrexate or sulfasalazine with measurements of interleukin-6 bioactivity .
9085442	0	methotrexate	120,132	interleukin-6	51,64	methotrexate	interleukin-6	MESH:D008727	3569	Chemical	Gene	factors|nmod|START_ENTITY END_ENTITY|nmod|factors	Relationship of soluble interleukin-2-receptor and interleukin-6 with class-specific rheumatoid factors during low-dose methotrexate treatment in rheumatoid_arthritis .
1491385	0	methotrexate	15,27	interleukin_1	31,44	methotrexate	interleukin 1	MESH:D008727	3552	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of methotrexate on interleukin_1 in patients with rheumatoid_arthritis .
8292668	0	methotrexate	23,35	interleukin_1	125,138	methotrexate	interleukin 1	MESH:D008727	3552	Chemical	Gene	action|nmod|START_ENTITY Mechanism|nmod|action Mechanism|dep|evidence evidence|dep|blocks blocks|dobj|the the|nmod|beta beta|nmod|receptor receptor|amod|END_ENTITY	Mechanism of action of methotrexate : experimental evidence that methotrexate blocks the binding of interleukin_1 beta to the interleukin_1 receptor on target cells .
8292668	0	methotrexate	64,76	interleukin_1	125,138	methotrexate	interleukin 1	MESH:D008727	3552	Chemical	Gene	blocks|nsubj|START_ENTITY blocks|dobj|the the|nmod|beta beta|nmod|receptor receptor|amod|END_ENTITY	Mechanism of action of methotrexate : experimental evidence that methotrexate blocks the binding of interleukin_1 beta to the interleukin_1 receptor on target cells .
10381034	0	methotrexate	75,87	interleukin_1_receptor_antagonist	11,44	methotrexate	interleukin 1 receptor antagonist	MESH:D008727	60582(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of interleukin_1_receptor_antagonist alone and in combination with methotrexate in adjuvant arthritic rats .
22193356	0	methotrexate	9,21	methionine_S-adenosyltransferase	31,63	methotrexate	methionine S-adenosyltransferase	MESH:D008727	4143	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Low-dose methotrexate inhibits methionine_S-adenosyltransferase in vitro and in vivo .
11138330	0	methotrexate	24,36	thymidylate_synthetase	40,62	methotrexate	thymidylate synthetase	MESH:D008727	7298	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activity activity|amod|END_ENTITY	The effects of low-dose methotrexate on thymidylate_synthetase activity in human peripheral blood mononuclear cells .
11863115	0	methotrexate	14,26	vascular_endothelial_growth_factor	117,151	methotrexate	vascular endothelial growth factor	MESH:D008727	7422	Chemical	Gene	START_ENTITY|dep|activity activity|nmod|levels levels|compound|END_ENTITY	Low-dose oral methotrexate and cyclophosphamide in metastatic breast_cancer : antitumor activity and correlation with vascular_endothelial_growth_factor levels .
21819747	0	methotrexate	11,23	vascular_endothelial_growth_factor	27,61	methotrexate	vascular endothelial growth factor	MESH:D008727	7422	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of methotrexate on vascular_endothelial_growth_factor , angiopoietin_1 , and angiopoietin_2 in nasal_polyps .
1314337	0	methoxamine	79,90	Neurohypophyseal	0,16	methoxamine	Neurohypophyseal	MESH:D008729	551	Chemical	Gene	START_ENTITY|nsubj|responses responses|amod|END_ENTITY	Neurohypophyseal and pituitary-adrenocortical responses to the alpha 1 agonist methoxamine in humans .
1760733	0	methoxamine	52,63	luteinizing_hormone-releasing_hormone	75,112	methoxamine	luteinizing hormone-releasing hormone	MESH:D008729	613033(Tax:9544)	Chemical	Gene	release|amod|START_ENTITY release|amod|END_ENTITY	Prostaglandin_E2 mediates the stimulatory effect of methoxamine on in vivo luteinizing_hormone-releasing_hormone -LRB- LH-RH -RRB- release in the ovariectomized female rhesus_monkey .
2506333	0	methoxsalen	44,55	cytochrome_P-450	24,40	methoxsalen	cytochrome P-450	MESH:D008730	25251(Tax:10116)	Chemical	Gene	inactivation|nmod|START_ENTITY inactivation|nmod|END_ENTITY	Suicide inactivation of cytochrome_P-450 by methoxsalen .
3105541	0	methoxsalen	9,20	cytochrome_P-450	46,62	methoxsalen	cytochrome P-450	MESH:D008730	13079(Tax:10090)	Chemical	Gene	START_ENTITY|appos|substrate substrate|nmod|END_ENTITY	The drug methoxsalen , a suicide substrate for cytochrome_P-450 , decreases the metabolic activation , and prevents the hepatotoxicity , of carbon_tetrachloride in mice .
19137497	0	methoxy_flavonoids	42,60	Adenosine_A1_receptor	0,21	methoxy flavonoids	Adenosine A1 receptor	null	134	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Adenosine_A1_receptor binding activity of methoxy_flavonoids from Orthosiphon stamineus .
18486176	0	methoxyacetic_acid	16,34	androgen_receptor	40,57	methoxyacetic acid	androgen receptor	MESH:C013598	11835(Tax:10090)	Chemical	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of methoxyacetic_acid with androgen_receptor .
20696580	0	methoxyflavonoids	24,41	CYP1B1	51,57	methoxyflavonoids	CYP1B1	null	1545	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|activity activity|compound|END_ENTITY	Selective inhibition of methoxyflavonoids on human CYP1B1 activity .
2988561	0	methoxyflurane	65,79	cytochrome_b5	19,32	methoxyflurane	cytochrome b5	MESH:D008733	100328915(Tax:9986)	Chemical	Gene	metabolism|nmod|START_ENTITY role|nmod|metabolism role|nmod|END_ENTITY	Obligatory role of cytochrome_b5 in the microsomal metabolism of methoxyflurane .
2450943	0	methoxyindoles	58,72	Hydroxyindole-O-methyltransferase	0,33	methoxyindoles	Hydroxyindole-O-methyltransferase	null	246281(Tax:10116)	Chemical	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Hydroxyindole-O-methyltransferase catalyses production of methoxyindoles in rat pineal gland dependent on the concentration of hydroxy precursors and their affinity for the enzyme .
1612412	0	methoxyneurosporene	27,46	dehydrogenase	47,60	methoxyneurosporene	dehydrogenase	null	3718867(Tax:272943)	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Nucleotide sequence of the methoxyneurosporene dehydrogenase gene from Rhodobacter_sphaeroides : comparison with other bacterial carotenoid dehydrogenases .
12093814	0	methoxyphenethylamines	13,35	cytochrome_P450_2D6	39,58	methoxyphenethylamines	cytochrome P450 2D6	null	1565	Chemical	Gene	Oxidation|nmod|START_ENTITY Oxidation|nmod|END_ENTITY	Oxidation of methoxyphenethylamines by cytochrome_P450_2D6 .
2109306	0	methyl	93,99	DNA_repair_protein	127,145	methyl	DNA repair protein	CHEBI:32875	442459	Chemical	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Purification to homogeneity and partial amino_acid sequence of a fragment which includes the methyl acceptor site of the human DNA_repair_protein for O6-methylguanine .
17967883	0	methyl	16,22	ICBP90	0,6	methyl	ICBP90	CHEBI:32875	29128	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	ICBP90 , a novel methyl K9 H3 binding protein linking protein ubiquitination with heterochromatin formation .
19331822	0	methyl	88,94	MeCP2	112,117	methyl	MeCP2	CHEBI:32875	4204	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Interaction between the inner nuclear membrane lamin_B_receptor and the heterochromatic methyl binding protein , MeCP2 .
23708816	0	methyl	111,117	MeCP2	144,149	methyl	MeCP2	CHEBI:32875	4204	Chemical	Gene	protein|amod|START_ENTITY protein|nmod|END_ENTITY	Ultrasensitive electrochemical immunoassay for DNA methyltransferase activity and inhibitor screening based on methyl binding domain protein of MeCP2 and enzymatic signal amplification .
8923477	0	methyl	66,72	S-adenosylhomocysteine_hydrolase	19,51	methyl	S-adenosylhomocysteine hydrolase	CHEBI:32875	269378(Tax:10090)	Chemical	Gene	system|compound|START_ENTITY END_ENTITY|nmod|system	Down-regulation of S-adenosylhomocysteine_hydrolase in the active methyl transfer system in the brain of genetically epileptic El mice .
25700986	0	methyl	4,10	SRD5A2	47,53	methyl	SRD5A2	CHEBI:32875	6716	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|nmod|END_ENTITY	DNA methyl transferase 1 reduces expression of SRD5A2 in the aging adult prostate .
21540068	0	methyl-b-cyclodextrin	24,45	interleukin-2	60,73	methyl-b-cyclodextrin	interleukin-2	null	3558	Chemical	Gene	START_ENTITY|acl|combined combined|nmod|END_ENTITY	Lower concentrations of methyl-b-cyclodextrin combined with interleukin-2 can preferentially induce activation and proliferation of natural killer cells in human peripheral blood .
21428286	0	methyl-lysine	55,68	L3MBTL1	87,94	methyl-lysine	L3MBTL1	null	26013	Chemical	Gene	pocket|amod|START_ENTITY pocket|nmod|END_ENTITY	Biophysical probes reveal a `` compromise '' nature of the methyl-lysine binding pocket in L3MBTL1 .
1319356	0	methyl-xanthines	15,31	myeloperoxidase	37,52	methyl-xanthines	myeloperoxidase	CHEBI:25348	4353	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of methyl-xanthines with myeloperoxidase .
24975036	0	methyl_3-O-methyl_gallate	44,69	miR-17-3p	20,29	methyl 3-O-methyl gallate	miR-17-3p	null	406952	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Modulation of human miR-17-3p expression by methyl_3-O-methyl_gallate as explanation of its in vivo protective activities .
15746193	0	methyl_CpG	11,21	Estrogen_receptor_alpha	74,97	methyl CpG	Estrogen receptor alpha	null	2099	Chemical	Gene	START_ENTITY|nmod|promoter promoter|compound|END_ENTITY	Release of methyl_CpG binding proteins and histone_deacetylase_1 from the Estrogen_receptor_alpha -LRB- ER -RRB- promoter upon reactivation in ER-negative human breast_cancer cells .
21467044	0	methyl_CpG	66,76	MeCP2	96,101	methyl CpG	MeCP2	null	4204	Chemical	Gene	START_ENTITY|dobj|protein protein|appos|END_ENTITY	DNA binding restricts the intrinsic conformational flexibility of methyl_CpG binding protein 2 -LRB- MeCP2 -RRB- .
18761004	0	methyl_CpG	14,24	Mecp2	44,49	methyl CpG	Mecp2	null	17257(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|protein protein|appos|END_ENTITY	Expression of methyl_CpG binding protein 2 -LRB- Mecp2 -RRB- during the postnatal development of the mouse brainstem .
8001979	0	methyl_CpG	50,60	Mecp2	78,83	methyl CpG	Mecp2	null	17257(Tax:10090)	Chemical	Gene	binding|amod|START_ENTITY protein|amod|binding protein|appos|END_ENTITY	Genetic and physical mapping of a gene encoding a methyl_CpG binding protein , Mecp2 , to the mouse X chromosome .
16319129	0	methyl_arginines	43,59	Fmrp	104,108	methyl arginines	Fmrp	null	37528(Tax:7227)	Chemical	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification and characterization of the methyl_arginines in the fragile_X_mental_retardation protein Fmrp .
10901160	0	methyl_chlorogenate	26,45	NFkappaB	14,22	methyl chlorogenate	NFkappaB	MESH:C417238	18033(Tax:10090)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of NFkappaB by methyl_chlorogenate from Eriobotrya japonica .
3603738	0	methyl_esters	26,39	Antithrombin	1,13	methyl esters	Antithrombin	null	462	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	-LSB- Antithrombin activity of methyl_esters of arginine-containing peptides -RSB- .
3686693	0	methyl_esters	22,35	thrombin	76,84	methyl esters	thrombin	null	2147	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Inhibitory effect of methyl_esters of arginine-containing oligopeptides on thrombin and trypsin -RSB- .
22634470	0	methyl_eugenol	52,66	Orco	29,33	methyl eugenol	Orco	MESH:C005223	40650(Tax:7227)	Chemical	Gene	upregulated|nmod|START_ENTITY upregulated|nsubjpass|END_ENTITY	Odorant receptor co-receptor Orco is upregulated by methyl_eugenol in male Bactrocera_dorsalis -LRB- Diptera : Tephritidae -RRB- .
17121182	0	methyl_gallate	11,25	Cyclooxygenase-2	68,84	methyl gallate	Cyclooxygenase-2	MESH:C052082	19225(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|dep|END_ENTITY	Effects of methyl_gallate on arachidonic_acid metabolizing enzymes : Cyclooxygenase-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells .
15537937	0	methyl_iodide	29,42	shank	70,75	methyl iodide	shank	MESH:C014055	22941	Chemical	Gene	Distribution|nmod|START_ENTITY Distribution|nmod|END_ENTITY	Distribution and leaching of methyl_iodide in soil following emulated shank and drip application .
8021922	0	methyl_ketones	55,69	cathepsin_B	22,33	methyl ketones	cathepsin B	CHEBI:51867	64529(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|inhibition inhibition|nmod|END_ENTITY	In vivo inhibition of cathepsin_B by peptidyl -LRB- acyloxy -RRB- methyl_ketones .
8294933	0	methyl_mercury	32,46	Phospholipase_A2	0,16	methyl mercury	Phospholipase A2	CHEBI:30785	151056	Chemical	Gene	stimulation|nmod|START_ENTITY stimulation|amod|END_ENTITY	Phospholipase_A2 stimulation by methyl_mercury in neuron culture .
22058658	0	methyl_methanesulfonate	10,33	hsp70	37,42	methyl methanesulfonate	hsp70	MESH:D008741	44920(Tax:7227)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of methyl_methanesulfonate on hsp70 expression and tissue damage in the third instar larvae of transgenic Drosophila_melanogaster -LRB- hsp70-lacZ -RRB- Bg .
18327812	0	methyl_methansulfonate	24,46	Mus81	88,93	methyl methansulfonate	Mus81	null	80198	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Decreased expression of methyl_methansulfonate and ultraviolet-sensitive gene clone 81 -LRB- Mus81 -RRB- is correlated with a poor prognosis in patients with hepatocellular_carcinoma .
1334799	0	methyl_phosphate	85,101	cTMP	139,143	methyl phosphate	cTMP	MESH:C027265	117145	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Nucleoside cyclic 3 ' ,5 ' - phosphates : chair-twist equilibria of the phosphate rings of methyl_phosphate and phenylphosphonate derivatives of cTMP .
11351275	0	methyl_pyruvate	16,31	GLP-1	35,40	methyl pyruvate	GLP-1	MESH:C104813	24952(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|action action|compound|END_ENTITY	Potentiation by methyl_pyruvate of GLP-1 insulinotropic action in normal rats .
1709825	0	methyl_xanthines	25,41	interleukin-2_receptor	50,72	methyl xanthines	interleukin-2 receptor	CHEBI:25348	3559	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|expression expression|amod|END_ENTITY	Pentoxifylline and other methyl_xanthines inhibit interleukin-2_receptor expression in human lymphocytes .
10194553	0	methylacetylenic_putrescine	11,38	ornithine_decarboxylase	43,66	methylacetylenic putrescine	ornithine decarboxylase	MESH:C039613	4953	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|inhibitor inhibitor|amod|END_ENTITY	Effects of methylacetylenic_putrescine , an ornithine_decarboxylase inhibitor and potential novel anticancer agent , on human and mouse cancer cell lines .
9703462	0	methylamide	72,83	NK1	114,117	methylamide	NK1	null	6869	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	2-Nitrophenylcarbamoyl - -LRB- S -RRB- - prolyl - -LRB- S -RRB- -3 - -LRB- 2-naphthyl -RRB- alanyl-N-benzyl-N - methylamide -LRB- SDZ_NKT 343 -RRB- , a potent human NK1 tachykinin receptor antagonist with good oral analgesic activity in chronic_pain models .
2475483	0	methylamine	104,115	alpha-2-macroglobulin	65,86	methylamine	alpha-2-macroglobulin	MESH:C027451	100352842(Tax:9986)	Chemical	Gene	Changes|nmod|START_ENTITY Changes|nmod|END_ENTITY	Changes in trypsin-binding properties and conformation of rabbit alpha-2-macroglobulin on reaction with methylamine .
2410421	0	methylamine	12,23	alpha_2-macroglobulin	35,56	methylamine	alpha 2-macroglobulin	MESH:C027451	2	Chemical	Gene	Reaction|nmod|START_ENTITY Reaction|nmod|END_ENTITY	Reaction of methylamine with human alpha_2-macroglobulin .
12213997	0	methylamine	59,70	semicarbazide-sensitive_amine_oxidase	99,136	methylamine	semicarbazide-sensitive amine oxidase	MESH:C027451	29473(Tax:10116)	Chemical	Gene	resistant|xcomp|START_ENTITY resistant|parataxis|correlation correlation|acl|END_ENTITY	Cultured rat vascular smooth muscle cells are resistant to methylamine toxicity : no correlation to semicarbazide-sensitive_amine_oxidase .
14715500	0	methylamine	22,33	semicarbazide-sensitive_amine_oxidase	75,112	methylamine	semicarbazide-sensitive amine oxidase	MESH:C027451	314	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|role role|nmod|END_ENTITY	Vasoactive effects of methylamine in isolated human blood vessels : role of semicarbazide-sensitive_amine_oxidase , formaldehyde , and hydrogen_peroxide .
15380725	0	methylamine	100,111	semicarbazide-sensitive_amine_oxidase	16,53	methylamine	semicarbazide-sensitive amine oxidase	MESH:C027451	314	Chemical	Gene	substrate|xcomp|START_ENTITY substrate|nsubj|Assay Assay|nmod|END_ENTITY	Assay of plasma semicarbazide-sensitive_amine_oxidase and determination of its endogenous substrate methylamine by liquid chromatography .
3342102	0	methylamine	15,26	semicarbazide-sensitive_amine_oxidase	30,67	methylamine	semicarbazide-sensitive amine oxidase	MESH:C027451	314	Chemical	Gene	Deamination|nmod|START_ENTITY Deamination|nmod|END_ENTITY	Deamination of methylamine by semicarbazide-sensitive_amine_oxidase in human umbilical artery and rat aorta .
23808802	0	methylated_glutathione	48,70	Glutathione_reductase	0,21	methylated glutathione	Glutathione reductase	null	2936	Chemical	Gene	analog|compound|START_ENTITY END_ENTITY|nmod|analog	Glutathione_reductase activity with an oxidized methylated_glutathione analog .
18539146	0	methylates	47,57	HemK2	0,5	methylates	HemK2	null	29104	Chemical	Gene	START_ENTITY|nsubj|protein protein|amod|END_ENTITY	HemK2 protein , encoded on human chromosome 21 , methylates translation termination factor eRF1 .
9848112	0	methylazoxymethanol	76,95	alcohol_dehydrogenase	12,33	methylazoxymethanol	alcohol dehydrogenase	MESH:C030667	58810(Tax:10090)	Chemical	Gene	metabolism|nmod|START_ENTITY role|nmod|metabolism role|nmod|END_ENTITY	The role of alcohol_dehydrogenase in the metabolism of the colon carcinogen methylazoxymethanol .
7032741	0	methylazoxymethanol	39,58	choline_dehydrogenase	128,149	methylazoxymethanol	choline dehydrogenase	MESH:C030667	290551(Tax:10116)	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Histochemical findings suggesting that methylazoxymethanol , a liver_and_kidney_carcinogen , is a substrate for hepatic and renal choline_dehydrogenase .
1915309	0	methylazoxymethanol_acetate	16,43	aldehyde_dehydrogenase	86,108	methylazoxymethanol acetate	aldehyde dehydrogenase	MESH:D008746	25375(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|presence presence|nmod|END_ENTITY	Mutagenicity of methylazoxymethanol_acetate in the presence of alcohol_dehydrogenase , aldehyde_dehydrogenase , and rat liver microsomes in Salmonella_typhimurium His G46 .
6718364	0	methylcellulose	14,29	erythropoietin	44,58	methylcellulose	erythropoietin	MESH:D008747	24335(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|production production|compound|END_ENTITY	The effect of methylcellulose on extrarenal erythropoietin production .
6089174	0	methylcholanthrene	25,43	cytochrome_P-450	73,89	methylcholanthrene	cytochrome P-450	MESH:D008748	25251(Tax:10116)	Chemical	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Distinct organization of methylcholanthrene - and phenobarbital-inducible cytochrome_P-450 genes in the rat .
2884771	0	methylcholanthrene	73,91	tumor_necrosis_factor	11,32	methylcholanthrene	tumor necrosis factor	MESH:D008748	21926(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Effects Effects|nmod|END_ENTITY	Effects of tumor_necrosis_factor -LRB- TNF -RRB- on transplanted tumors induced by methylcholanthrene in mice .
1268617	0	methyldopa	11,21	prolactin	25,34	methyldopa	prolactin	MESH:D008750	5617	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of methyldopa on prolactin and growth_hormone .
3203713	0	methyldopa	10,20	prolactin	24,33	methyldopa	prolactin	MESH:D008750	5617	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|concentration concentration|amod|END_ENTITY	Effect of methyldopa on prolactin serum concentration .
24486702	0	methylene_blue	20,34	SIRT1	0,5	methylene blue	SIRT1	MESH:D008751	93759(Tax:10090)	Chemical	Gene	activation|nmod|START_ENTITY activation|nummod|END_ENTITY	SIRT1 activation by methylene_blue , a repurposed drug , leads to AMPK-mediated inhibition of steatosis and steatohepatitis .
17081665	0	methylene_blue	7,21	aid	38,41	methylene blue	aid	MESH:D008751	57379	Chemical	Gene	Use|nmod|START_ENTITY Use|nmod|END_ENTITY	Use of methylene_blue as a diagnostic aid in early detection of oral_cancer and precancerous_lesions .
11457468	0	methylene_tetrahydrofolate	34,60	MTHFR	72,77	methylene tetrahydrofolate	MTHFR	CHEBI:25297	4524	Chemical	Gene	reductase|amod|START_ENTITY reductase|appos|C C|compound|END_ENTITY	Mutations in the genes regulating methylene_tetrahydrofolate reductase -LRB- MTHFR C -- > T677 -RRB- and cystathione_beta-synthase -LRB- CBS G -- > A919 , CBS T -- > c833 -RRB- are not associated with myocardial_infarction in African Americans .
12605391	0	methylene_tetrahydrofolate	44,70	MTHFR	82,87	methylene tetrahydrofolate	MTHFR	CHEBI:25297	4524	Chemical	Gene	reductase|amod|START_ENTITY variant|nmod|reductase homocysteine|dobj|variant homocysteine|dep|END_ENTITY	Serum homocysteine , thermolabile variant of methylene_tetrahydrofolate reductase -LRB- MTHFR -RRB- , and venous_thromboembolism : Longitudinal_Investigation_of_Thromboembolism_Etiology -LRB- LITE -RRB- .
19793004	0	methylene_tetrahydrofolate	71,97	MTHFR	114,119	methylene tetrahydrofolate	MTHFR	CHEBI:25297	4524	Chemical	Gene	reductase|amod|START_ENTITY polymorphisms|amod|reductase polymorphisms|appos|END_ENTITY	Homocysteine levels are associated with cervical_cancer independent of methylene_tetrahydrofolate reductase gene -LRB- MTHFR -RRB- polymorphisms in Indian population .
22144047	0	methylene_tetrahydrofolate	40,66	MTHFR	78,83	methylene tetrahydrofolate	MTHFR	CHEBI:25297	4524	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A single-nucleotide polymorphism in the methylene_tetrahydrofolate reductase -LRB- MTHFR -RRB- gene is associated with risk of radiation_pneumonitis in lung_cancer patients treated with thoracic radiation therapy .
24449370	0	methylene_tetrahydrofolate	37,63	MTHFR	75,80	methylene tetrahydrofolate	MTHFR	CHEBI:25297	4524	Chemical	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Adaptive developmental plasticity in methylene_tetrahydrofolate reductase -LRB- MTHFR -RRB- C677T polymorphism limits its frequency in South Indians .
25937730	0	methylene_tetrahydrofolate	53,79	MTHFR	91,96	methylene tetrahydrofolate	MTHFR	CHEBI:25297	4524	Chemical	Gene	reductase|amod|START_ENTITY reductase|appos|END_ENTITY	Internal_jugular_vein_thrombosis due to heterozygote methylene_tetrahydrofolate reductase -LRB- MTHFR -RRB- 1298C and Factor V G1691A mutations after a minor trauma .
26009115	1	methylene_tetrahydrofolate	20,46	MTHFR	58,63	methylene tetrahydrofolate	MTHFR	CHEBI:25297	4524	Chemical	Gene	START_ENTITY|dobj|polymorphism polymorphism|appos|END_ENTITY	Study of C677T methylene_tetrahydrofolate reductase -LRB- MTHFR -RRB- polymorphism in preeclampsia .
26843177	0	methylene_tetrahydrofolate	24,50	MTHFR	62,67	methylene tetrahydrofolate	MTHFR	CHEBI:25297	4524	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Decreased expression of methylene_tetrahydrofolate reductase -LRB- MTHFR -RRB- gene in patients with rheumatoid_arthritis .
10444193	0	methylene_tetrahydrofolate	43,69	glycoprotein_Ia	20,35	methylene tetrahydrofolate	glycoprotein Ia	CHEBI:25297	22915	Chemical	Gene	START_ENTITY|nsubj|Contribution Contribution|nmod|END_ENTITY	Contribution of the glycoprotein_Ia 807TT , methylene_tetrahydrofolate reductase 677TT and prothrombin 20210GA genotypes to prothrombotic risk among factor V 1691GA -LRB- Leiden -RRB- carriers .
10235429	0	methylene_tetrahydrofolate	51,77	prothrombin	38,49	methylene tetrahydrofolate	prothrombin	CHEBI:25297	2147	Chemical	Gene	reductase|amod|START_ENTITY reductase|amod|END_ENTITY	Venous_thromboembolic_disease and the prothrombin , methylene_tetrahydrofolate reductase and factor V genes .
12126777	0	methyleneaminoxymethyl	17,39	cyclooxygenase-2	80,96	methyleneaminoxymethyl	cyclooxygenase-2	null	5743	Chemical	Gene	analogues|compound|START_ENTITY analogues|nmod|inhibitors inhibitors|amod|END_ENTITY	Aryl-substituted methyleneaminoxymethyl -LRB- MAOM -RRB- analogues of diarylcyclopentenyl cyclooxygenase-2 inhibitors : effects of some structural modifications on their biological properties .
17387004	0	methylenedioxymethamphetamine	92,121	CYP2D6	47,53	methylenedioxymethamphetamine	CYP2D6	MESH:D018817	1565	Chemical	Gene	cryopreserved|nmod|START_ENTITY cryopreserved|nsubj|Kinetics Kinetics|nmod|inactivation inactivation|nmod|END_ENTITY	Kinetics of the time-dependent inactivation of CYP2D6 in cryopreserved human hepatocytes by methylenedioxymethamphetamine -LRB- MDMA -RRB- .
17574396	0	methylenedioxymethamphetamine	26,55	CYP2D6	16,22	methylenedioxymethamphetamine	CYP2D6	MESH:D018817	24303(Tax:10116)	Chemical	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of CYP2D6 by methylenedioxymethamphetamine in different recombinant expression systems .
7909223	0	methylenedioxymethamphetamine	23,52	CYP2D6	94,100	methylenedioxymethamphetamine	CYP2D6	MESH:D018817	1565	Chemical	Gene	demethylenation|nmod|START_ENTITY ecstasy|nsubj|demethylenation ecstasy|nmod|hydroxylase hydroxylase|appos|END_ENTITY	The demethylenation of methylenedioxymethamphetamine -LRB- `` ecstasy '' -RRB- by debrisoquine hydroxylase -LRB- CYP2D6 -RRB- .
2996791	0	methylenedioxyphenyl	60,80	cytochrome_P-450	17,33	methylenedioxyphenyl	cytochrome P-450	null	13079(Tax:10090)	Chemical	Gene	compounds|amod|START_ENTITY END_ENTITY|nmod|compounds	The induction of cytochrome_P-450 by isosafrole and related methylenedioxyphenyl compounds .
25118499	0	methylenetetrahydrofolate	35,60	MTHFD1	81,87	methylenetetrahydrofolate	MTHFD1	CHEBI:25297	4522	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The role of 401a > G polymorphism of methylenetetrahydrofolate dehydrogenase gene -LRB- MTHFD1 -RRB- in fetal hypotrophy .
25213861	4	methylenetetrahydrofolate	934,959	MTHFD1	900,906	methylenetetrahydrofolate	MTHFD1	CHEBI:25297	4522	Chemical	Gene	generates|xcomp|START_ENTITY enzyme|acl:relcl|generates methylenetetrahydrofolate_dehydrogenase_1|appos|enzyme methylenetetrahydrofolate_dehydrogenase_1|appos|END_ENTITY	In this study we demonstrate that methylenetetrahydrofolate_dehydrogenase_1 -LRB- MTHFD1 -RRB- , an enzyme that generates methylenetetrahydrofolate from formate , ATP , and NADPH , functions in the nucleus to support de novo thymidylate biosynthesis .
9569181	0	methylenetetrahydrofolate	41,66	MTHFR	78,83	methylenetetrahydrofolate	MTHFR	CHEBI:25297	4524	Chemical	Gene	reductase|compound|START_ENTITY reductase|appos|END_ENTITY	The high prevalence of thermolabile 5-10 methylenetetrahydrofolate reductase -LRB- MTHFR -RRB- in Italians is not associated to an increased risk for coronary_artery_disease -LRB- CAD -RRB- .
22217364	0	methylentetraydrofolate	15,38	MTHFR	50,55	methylentetraydrofolate	MTHFR	null	4524	Chemical	Gene	reductase|amod|START_ENTITY reductase|appos|END_ENTITY	Association of methylentetraydrofolate reductase -LRB- MTHFR -RRB- 677_C _ > _ T gene polymorphism and homocysteine levels in psoriasis_vulgaris patients from Malaysia : a case-control study .
3410600	0	methylepoxyproscillaridin	22,47	P35	49,52	methylepoxyproscillaridin	P35	MESH:C056946	3592	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Hemodynamic effect of methylepoxyproscillaridin -LRB- P35 -RRB- in patients with congestive_myocardiopathy .
463447	0	methylergometrine_hydrogenmaleate	41,74	prolactin	14,23	methylergometrine hydrogenmaleate	prolactin	null	5617	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of prolactin and lactation by methylergometrine_hydrogenmaleate .
6518192	0	methylethyl_ketone	29,47	monoamine_oxidase	65,82	methylethyl ketone	monoamine oxidase	MESH:C005222	29253(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of solubilization by methylethyl_ketone of mitochondrial monoamine_oxidase of the rat liver on the kinetic properties of the enzyme -RSB- .
26781667	0	methylglucoside	25,40	CO2	58,61	methylglucoside	CO2	MESH:C027020	717	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	Interactions of acylated methylglucoside derivatives with CO2 : simulation and calculations .
21124777	0	methylglyoxal	96,109	CHIP	41,45	methylglyoxal	CHIP	MESH:D011765	10273	Chemical	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	The chaperone-dependent ubiquitin ligase CHIP targets HIF-1a for degradation in the presence of methylglyoxal .
18812164	0	methylglyoxal	31,44	Gcn4	8,12	methylglyoxal	Gcn4	MESH:D011765	856709(Tax:4932)	Chemical	Gene	Role|acl|START_ENTITY Role|nmod|END_ENTITY	Role of Gcn4 for adaptation to methylglyoxal in Saccharomyces_cerevisiae : methylglyoxal attenuates protein synthesis through phosphorylation of eIF2alpha .
12527413	0	methylglyoxal	80,93	Glyceraldehyde-3-phosphate_dehydrogenase	0,40	methylglyoxal	Glyceraldehyde-3-phosphate dehydrogenase	MESH:D011765	2597	Chemical	Gene	levels|amod|START_ENTITY modifier|nmod|levels activity|nmod|modifier activity|amod|END_ENTITY	Glyceraldehyde-3-phosphate_dehydrogenase activity as an independent modifier of methylglyoxal levels in diabetes .
21497196	0	methylglyoxal	45,58	Heat-shock_protein_27	0,21	methylglyoxal	Heat-shock protein 27	MESH:D011765	3315	Chemical	Gene	target|nmod|START_ENTITY END_ENTITY|nmod|target	Heat-shock_protein_27 -LRB- Hsp27 -RRB- as a target of methylglyoxal in gastrointestinal_cancer .
27061807	0	methylglyoxal	10,23	HspB6	103,108	methylglyoxal	HspB6	MESH:D011765	126393	Chemical	Gene	modification|amod|START_ENTITY Effect|nmod|modification Effect|nmod|END_ENTITY	Effect of methylglyoxal modification on the structure and properties of human small heat shock protein HspB6 -LRB- Hsp20 -RRB- .
9450641	0	methylglyoxal	85,98	glyceraldehyde-3-phosphate_dehydrogenase	16,56	methylglyoxal	glyceraldehyde-3-phosphate dehydrogenase	MESH:D011765	2597	Chemical	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of glyceraldehyde-3-phosphate_dehydrogenase of human malignant cells by methylglyoxal .
17670746	0	methylglyoxal	95,108	mSin3A	125,131	methylglyoxal	mSin3A	MESH:D011765	20466(Tax:10090)	Chemical	Gene	modification|amod|START_ENTITY modification|nmod|END_ENTITY	High glucose increases angiopoietin-2 transcription in microvascular endothelial cells through methylglyoxal modification of mSin3A .
10503937	0	methylguanidine	54,69	TNFalpha	21,29	methylguanidine	TNFalpha	MESH:D008760	24835(Tax:10116)	Chemical	Gene	modulation|nmod|START_ENTITY modulation|amod|END_ENTITY	In vitro and in vivo TNFalpha synthesis modulation by methylguanidine , an uremic catabolyte .
7759207	0	methylguanidine	59,74	erythropoietin	28,42	methylguanidine	erythropoietin	MESH:D008760	2056	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of recombinant human erythropoietin on synthesis of methylguanidine in uraemic patients on haemodialysis or continuous ambulatory peritoneal dialysis .
686917	0	methylhistamine	8,23	histidine_decarboxylase	66,89	methylhistamine	histidine decarboxylase	CHEBI:29009	24443(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|amod|END_ENTITY	Urinary methylhistamine as an index of histamine formation during histidine_decarboxylase inhibition in the rat .
23292653	0	methyllysine	46,58	L3MBTL3	38,45	methyllysine	L3MBTL3	null	84456	Chemical	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain .
4105306	0	methylmercaptoimidazole	22,45	thyroglobulin	66,79	methylmercaptoimidazole	thyroglobulin	MESH:D008713	7038	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|structure structure|nmod|END_ENTITY	Effect of freezing in methylmercaptoimidazole on the structure of thyroglobulin .
20118630	0	methylmercury	83,96	CK-5	43,47	methylmercury	CK-5	CHEBI:30785	110308(Tax:10090)	Chemical	Gene	absorption|nmod|START_ENTITY END_ENTITY|nmod|absorption	The influence of Parachlorella beyerinckii CK-5 on the absorption and excretion of methylmercury -LRB- MeHg -RRB- in mice .
926459	0	methylmercury	10,23	alcohol_dehydrogenase	86,107	methylmercury	alcohol dehydrogenase	CHEBI:30785	78959(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of methylmercury on the ethanol elimination from the blood and the activity of alcohol_dehydrogenase .
20631062	0	methylmercury	44,57	brain-derived_neurotrophic_factor	61,94	methylmercury	brain-derived neurotrophic factor	CHEBI:30785	627	Chemical	Gene	START_ENTITY|nmod|concentrations concentrations|amod|END_ENTITY	Effects of maternal smoking and exposure to methylmercury on brain-derived_neurotrophic_factor concentrations in umbilical cord serum .
4049277	0	methylmercury	101,114	ornithine_decarboxylase	127,150	methylmercury	ornithine decarboxylase	CHEBI:30785	24609(Tax:10116)	Chemical	Gene	exposure|compound|START_ENTITY exposure|nmod|END_ENTITY	Early biochemical detection of adverse effects of a neurobehavioral teratogen : influence of prenatal methylmercury exposure on ornithine_decarboxylase in brain and other tissues of fetal and neonatal rat .
11769628	0	methylmercury_chloride	11,33	c-fos	41,46	methylmercury chloride	c-fos	MESH:C004925	314322(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effect of methylmercury_chloride on the c-fos expression in brain nerve cells of the rats -RSB- .
15225883	0	methylmethane_sulfonate	71,94	GADD34	20,26	methylmethane sulfonate	GADD34	MESH:D008741	17872(Tax:10090)	Chemical	Gene	transcription|nmod|START_ENTITY transcription|nsubj|Regulation Regulation|nmod|gene gene|compound|END_ENTITY	Regulation of mouse GADD34 gene transcription after DNA damaging agent methylmethane_sulfonate .
1455421	0	methylparathion	33,48	acetylcholinesterase	71,91	methylparathion	acetylcholinesterase	MESH:D008743	83817(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|compound|END_ENTITY	Effect of chronic consumption of methylparathion on rat brain regional acetylcholinesterase activity and on levels of biogenic amines .
171888	0	methylparathion	100,115	acetylcholinesterase	65,85	methylparathion	acetylcholinesterase	MESH:D008743	11423(Tax:10090)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	-LSB- Effects of diethyldithiocarbamate on the acute toxicity and the acetylcholinesterase inhibition by methylparathion in mice -RSB- .
10831022	0	methylphenidate	32,47	CYP2D6	51,57	methylphenidate	CYP2D6	MESH:D008774	1565	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY pharmacokinetics|nmod|metabolizers metabolizers|nummod|END_ENTITY	Single-dose pharmacokinetics of methylphenidate in CYP2D6 extensive and poor metabolizers .
19576520	0	methylphenidate	70,85	DARPP-32	106,114	methylphenidate	DARPP-32	MESH:D008774	360616(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|involvement involvement|nmod|END_ENTITY	Early long-term exposure with caffeine induces cross-sensitization to methylphenidate with involvement of DARPP-32 in adulthood of rats .
14586159	0	methylphenidate	32,47	DHEA-S	141,147	methylphenidate	DHEA-S	MESH:D008774	6822	Chemical	Gene	course|nmod|START_ENTITY increases|nsubj|course increases|dobj|levels levels|nmod|dehydroepiandrosterone dehydroepiandrosterone|appos|END_ENTITY	Three-month treatment course of methylphenidate increases plasma levels of dehydroepiandrosterone -LRB- DHEA -RRB- and dehydroepiandrosterone-sulfate -LRB- DHEA-S -RRB- in attention_deficit_hyperactivity_disorder .
17763937	0	methylphenidate	11,26	DHEA-S	44,50	methylphenidate	DHEA-S	MESH:D008774	6822	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|amod|END_ENTITY	Effects of methylphenidate and bupropion on DHEA-S and cortisol plasma levels in attention-deficit_hyperactivity_disorder .
12619042	0	methylphenidate	39,54	Dopamine_transporter	0,20	methylphenidate	Dopamine transporter	MESH:D008774	6531	Chemical	Gene	flow|compound|START_ENTITY response|nmod|flow gene|appos|response gene|amod|END_ENTITY	Dopamine_transporter gene , response to methylphenidate and cerebral blood flow in attention-deficit/hyperactivity _ disorder : a pilot study .
16139732	0	methylphenidate	95,110	Dopamine_transporter	0,20	methylphenidate	Dopamine transporter	MESH:D008774	6531	Chemical	Gene	cessation|nmod|START_ENTITY normalizes|nmod|cessation normalizes|nsubj|END_ENTITY	Dopamine_transporter in attention-deficit_hyperactivity_disorder normalizes after cessation of methylphenidate .
17314918	0	methylphenidate	73,88	Dopamine_transporter	0,20	methylphenidate	Dopamine transporter	MESH:D008774	6531	Chemical	Gene	associated|xcomp|START_ENTITY associated|nsubj|gene gene|amod|END_ENTITY	Dopamine_transporter gene -LRB- DAT1 -RRB- associated with appetite suppression to methylphenidate in a case-control study of binge_eating_disorder .
24676965	0	methylphenidate	34,49	Dopamine_transporter	0,20	methylphenidate	Dopamine transporter	MESH:D008774	6531	Chemical	Gene	occupancy|nmod|START_ENTITY occupancy|amod|END_ENTITY	Dopamine_transporter occupancy by methylphenidate and impulsivity in adult ADHD .
9766762	0	methylphenidate	89,104	Dopamine_transporter	0,20	methylphenidate	Dopamine transporter	MESH:D008774	6531	Chemical	Gene	doses|nmod|START_ENTITY induced|nmod|doses brain|acl|induced occupancies|nmod|brain occupancies|nsubj|END_ENTITY	Dopamine_transporter occupancies in the human brain induced by therapeutic doses of oral methylphenidate .
11978395	0	methylphenidate	86,101	c-fos	28,33	methylphenidate	c-fos	MESH:D008774	14281(Tax:10090)	Chemical	Gene	administration|compound|START_ENTITY distribution|nmod|administration distribution|nmod|expression expression|amod|END_ENTITY	Age-related distribution of c-fos expression in the striatum of CD-1 mice after acute methylphenidate administration .
12692480	0	methylphenidate	6,21	c-fos	48,53	methylphenidate	c-fos	MESH:D008774	314322(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY attenuates|nsubj|administration attenuates|dobj|expression expression|amod|END_ENTITY	Daily methylphenidate administration attenuates c-fos expression in the striatum of prepubertal rats .
15076731	0	methylphenidate	10,25	c-fos	51,56	methylphenidate	c-fos	MESH:D008774	14281(Tax:10090)	Chemical	Gene	down-regulates|amod|START_ENTITY END_ENTITY|nsubj|down-regulates	Long-term methylphenidate treatment down-regulates c-fos in the striatum of male CD-1 mice .
15637641	0	methylphenidate	14,29	c-fos	105,110	methylphenidate	c-fos	MESH:D008774	314322(Tax:10116)	Chemical	Gene	Topography|nmod|START_ENTITY Topography|dep|effects effects|nmod|END_ENTITY	Topography of methylphenidate -LRB- ritalin -RRB- - induced gene regulation in the striatum : differential effects on c-fos , substance P and opioid peptides .
22774458	0	methylphenidate	78,93	c-fos	51,56	methylphenidate	c-fos	MESH:D008774	2353	Chemical	Gene	therapy|amod|START_ENTITY expression|nmod|therapy expression|amod|END_ENTITY	Changing the general factor of personality and the c-fos gene expression with methylphenidate and self-regulation therapy .
8943072	0	methylphenidate	51,66	c-fos	117,122	methylphenidate	c-fos	MESH:D008774	493935(Tax:9685)	Chemical	Gene	targets|appos|START_ENTITY evidenced|nsubj|targets evidenced|nmod|immunocytochemistry immunocytochemistry|amod|END_ENTITY	Potential brain neuronal targets for amphetamine - , methylphenidate - , and modafinil-induced wakefulness , evidenced by c-fos immunocytochemistry in the cat .
24416225	0	methylphenidate	10,25	cancer-related_fatigue	43,65	methylphenidate	cancer-related fatigue	MESH:D008774	10882	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	Effect of methylphenidate in patients with cancer-related_fatigue : a systematic review and meta-analysis .
10037500	0	methylphenidate	11,26	dopamine_transporter	83,103	methylphenidate	dopamine transporter	MESH:D008774	6531	Chemical	Gene	analogues|amod|START_ENTITY analogues|nmod|substrates substrates|nmod|END_ENTITY	Effects of methylphenidate analogues on phenethylamine substrates for the striatal dopamine_transporter : potential as amphetamine antagonists ?
10596245	0	methylphenidate	62,77	dopamine_transporter	19,39	methylphenidate	dopamine transporter	MESH:D008774	6531	Chemical	Gene	response|compound|START_ENTITY Association|nmod|response Association|nmod|gene gene|compound|END_ENTITY	Association of the dopamine_transporter gene -LRB- DAT1 -RRB- with poor methylphenidate response .
10793238	0	methylphenidate	116,131	dopamine_transporter	19,39	methylphenidate	dopamine transporter	MESH:D008774	6531	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|dep|effects	Increased striatal dopamine_transporter in adult patients with attention_deficit_hyperactivity_disorder : effects of methylphenidate as measured by single photon emission computed tomography .
11083541	0	methylphenidate	114,129	dopamine_transporter	76,96	methylphenidate	dopamine transporter	MESH:D008774	6531	Chemical	Gene	treatment|amod|START_ENTITY -RSB-|nmod|treatment -RSB-|nmod|END_ENTITY	Attention deficit_hyperactivity_disorder : binding of -LSB- 99mTc -RSB- TRODAT-1 to the dopamine_transporter before and after methylphenidate treatment .
15572278	0	methylphenidate	200,215	dopamine_transporter	41,61	methylphenidate	dopamine transporter	MESH:D008774	6531	Chemical	Gene	relating|xcomp|START_ENTITY allele|parataxis|relating allele|nmod|gene gene|compound|END_ENTITY	The homozygosity for 10-repeat allele at dopamine_transporter gene and dopamine_transporter density in Korean children with attention_deficit_hyperactivity_disorder : relating to treatment response to methylphenidate .
16091862	0	methylphenidate	75,90	dopamine_transporter	22,42	methylphenidate	dopamine transporter	MESH:D008774	6531	Chemical	Gene	response|acl|START_ENTITY availability|nmod|response availability|compound|END_ENTITY	Influence of striatal dopamine_transporter availability on the response to methylphenidate in adult patients with ADHD .
16123773	0	methylphenidate	110,125	dopamine_transporter	20,40	methylphenidate	dopamine transporter	MESH:D008774	6531	Chemical	Gene	genotype|xcomp|START_ENTITY genotype|nsubj|Association Association|nmod|END_ENTITY	Association between dopamine_transporter -LRB- DAT1 -RRB- genotype , left-sided inattention , and an enhanced response to methylphenidate in attention-deficit_hyperactivity_disorder .
17228864	0	methylphenidate	46,61	dopamine_transporter	96,116	methylphenidate	dopamine transporter	MESH:D008774	6531	Chemical	Gene	START_ENTITY|nmod|selectivity selectivity|nmod|END_ENTITY	Slow-onset , long-duration , alkyl analogues of methylphenidate with enhanced selectivity for the dopamine_transporter .
18563707	0	methylphenidate	20,35	dopamine_transporter	111,131	methylphenidate	dopamine transporter	MESH:D008774	6531	Chemical	Gene	response|amod|START_ENTITY Pharmacogenetics|nmod|response Pharmacogenetics|dep|hyperactivity_disorder hyperactivity_disorder|dep|association association|nmod|gene gene|compound|END_ENTITY	Pharmacogenetics of methylphenidate response in attention_deficit / hyperactivity_disorder : association with the dopamine_transporter gene -LRB- SLC6A3 -RRB- .
23402315	0	methylphenidate	23,38	dopamine_transporter	96,116	methylphenidate	dopamine transporter	MESH:D008774	36849(Tax:7227)	Chemical	Gene	administration|nmod|START_ENTITY blocks|nsubj|administration blocks|nmod|uptake uptake|nmod|END_ENTITY	Oral administration of methylphenidate blocks the effect of cocaine on uptake at the Drosophila dopamine_transporter .
23588108	0	methylphenidate	87,102	dopamine_transporter	41,61	methylphenidate	dopamine transporter	MESH:D008774	6531	Chemical	Gene	Meta-analysis|acl|START_ENTITY Meta-analysis|nmod|association association|nmod|genotype genotype|compound|END_ENTITY	Meta-analysis of the association between dopamine_transporter genotype and response to methylphenidate treatment in ADHD .
6482679	0	methylphenidate	64,79	growth_hormone	91,105	methylphenidate	growth hormone	MESH:D008774	2688	Chemical	Gene	treatment|amod|START_ENTITY sensitivity|nmod|treatment change|nmod|sensitivity change|dep|response response|compound|END_ENTITY	Possible change in noradrenergic receptor sensitivity following methylphenidate treatment : growth_hormone and MHPG response to clonidine challenge in children with attention_deficit_disorder and hyperactivity .
9197950	0	methylphenidate	18,33	growth_hormone	43,57	methylphenidate	growth hormone	MESH:D008774	2688	Chemical	Gene	Lack|nmod|START_ENTITY Lack|nmod|END_ENTITY	Lack of effect of methylphenidate on serum growth_hormone -LRB- GH -RRB- , GH-binding_protein , and insulin-like_growth_factor_I .
9685452	0	methylphenidate	83,98	growth_hormone	12,26	methylphenidate	growth hormone	MESH:D008774	2688	Chemical	Gene	therapy|amod|START_ENTITY effects|nmod|therapy Response|dep|effects Response|acl|END_ENTITY	Response to growth_hormone in attention_deficit_hyperactivity_disorder : effects of methylphenidate and pemoline therapy .
24994482	0	methylphenidate	10,25	leptin	62,68	methylphenidate	leptin	MESH:D008774	3952	Chemical	Gene	treatment|amod|START_ENTITY Effect|nmod|treatment Effect|nmod|END_ENTITY	Effect of methylphenidate treatment on appetite and levels of leptin , ghrelin , adiponectin , and brain-derived_neurotrophic_factor in children and adolescents with attention_deficit and hyperactivity_disorder .
15533049	0	methylphosphonate	11,28	Pho84	129,134	methylphosphonate	Pho84	MESH:C032627	854916(Tax:4932)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of methylphosphonate , a phosphate analogue , on the expression and degradation of the high-affinity phosphate transporter Pho84 , in Saccharomyces_cerevisiae .
1841270	0	methylphosphonate	31,48	p65	75,78	methylphosphonate	p65	MESH:C032627	19697(Tax:10090)	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|expression expression|amod|END_ENTITY	Antisense oligodeoxynucleoside methylphosphonate inhibition of mouse c-myc p65 protein expression in E mu-c-myc transgenic_mice .
2540005	0	methylprednisolone	66,84	ACTH	33,37	methylprednisolone	ACTH	MESH:D008775	5443	Chemical	Gene	trial|nmod|START_ENTITY trial|nmod|END_ENTITY	Double-blind randomized trial of ACTH versus dexamethasone versus methylprednisolone in multiple_sclerosis bouts .
17827967	0	methylprednisolone	142,160	CXCL11	0,6	methylprednisolone	CXCL11	MESH:D008775	6373	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|END_ENTITY	CXCL11 -LRB- Interferon-inducible_T-cell_alpha_chemoattractant -RRB- and interleukin-18 in relapsing-remitting multiple_sclerosis patients treated with methylprednisolone .
16002152	0	methylprednisolone	10,28	FcgammaRI	37,46	methylprednisolone	FcgammaRI	MESH:D008775	2209	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	High dose methylprednisolone induces FcgammaRI on granulocytes in MS-patients .
10634646	0	methylprednisolone	31,49	G-CSF	11,16	methylprednisolone	G-CSF	MESH:D008775	1440	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of G-CSF and high-dose methylprednisolone on peripheral stem cells , serum IL-3 levels and hematological parameters in acute_lymphoblastic_leukemia patients with neutropenia : a pilot study .
9379687	0	methylprednisolone	33,51	IL-2	71,75	methylprednisolone	IL-2	MESH:D008775	3558	Chemical	Gene	treatment|compound|START_ENTITY treatment|nmod|levels levels|compound|END_ENTITY	Effect of short-course high-dose methylprednisolone treatment on serum IL-2 levels in children with myelodysplastic_syndromes : a pilot study .
8778466	0	methylprednisolone	16,34	LFA-1	56,61	methylprednisolone	LFA-1	MESH:D008775	308995(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Suppression by methylprednisolone of the expression of LFA-1 by alveolar macrophages in irradiated rat lungs -RSB- .
11913542	0	methylprednisolone	23,41	P-glycoprotein	63,77	methylprednisolone	P-glycoprotein	MESH:D008775	5243	Chemical	Gene	transport|nmod|START_ENTITY mediated|nsubj|transport mediated|nmod|END_ENTITY	Secretory transport of methylprednisolone possibly mediated by P-glycoprotein in Caco-2 cells .
19228956	0	methylprednisolone	40,58	STAT5	0,5	methylprednisolone	STAT5	MESH:D008775	6776	Chemical	Gene	effects|nmod|START_ENTITY mediates|dobj|effects mediates|nsubj|END_ENTITY	STAT5 mediates antiapoptotic effects of methylprednisolone on oligodendrocytes .
15652760	0	methylprednisolone	10,28	TNF	72,75	methylprednisolone	TNF	MESH:D008775	7124	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Liposomal methylprednisolone differentially regulates the expression of TNF and IL-10 in human alveolar macrophages .
24131837	0	methylprednisolone	20,38	TNF-a	48,53	methylprednisolone	TNF-a	MESH:D008775	7124	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|level level|amod|END_ENTITY	-LSB- Effect of low-dose methylprednisolone on serum TNF-a level in children with Mycoplasma_pneumoniae pneumonia -RSB- .
10477400	0	methylprednisolone	132,150	Tumor_necrosis_factor-alpha	0,27	methylprednisolone	Tumor necrosis factor-alpha	MESH:D008775	7124	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha and its soluble receptors in plasma and cerebrospinal fluid of multiple_sclerosis patients treated with methylprednisolone .
18475732	0	methylprednisolone	89,107	annexin-1	13,22	methylprednisolone	annexin-1	MESH:D008775	25380(Tax:10116)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of annexin-1 at transcriptional and post-transcriptional level in rat brain by methylprednisolone and the 21-aminosteroid U74389F .
9812563	0	methylprednisolone	12,30	interleukin-1_beta-converting_enzyme	81,117	methylprednisolone	interleukin-1 beta-converting enzyme	MESH:D008775	12362(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of methylprednisolone -LRB- MPS -RRB- on induction of apoptosis and expression of interleukin-1_beta-converting_enzyme -LRB- ICE -RRB- in the kidneys of MRL-LPR/LPR mice -RSB- .
7473176	0	methylprednisolone	11,29	interleukin-6_and_tumor_necrosis_factor-alpha	70,115	methylprednisolone	interleukin-6 and tumor necrosis factor-alpha	MESH:D008775	3569;7124	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|production production|amod|END_ENTITY	Effects of methylprednisolone and 21-aminosteroids on mitogen-induced interleukin-6_and_tumor_necrosis_factor-alpha production in human peripheral blood mononuclear cells .
9130032	0	methylprednisolone	55,73	leptin	98,104	methylprednisolone	leptin	MESH:D008775	3952	Chemical	Gene	glucocorticoids|appos|START_ENTITY administration|nmod|glucocorticoids affect|nsubj|administration affect|dobj|concentration concentration|compound|END_ENTITY	Acute and prolonged administration of glucocorticoids -LRB- methylprednisolone -RRB- does not affect plasma leptin concentration in humans .
19583607	0	methylprednisolone	13,31	neuron-specific_enolase	45,68	methylprednisolone	neuron-specific enolase	MESH:D008775	2026	Chemical	Gene	START_ENTITY|nmod|levels levels|nmod|END_ENTITY	Influence of methylprednisolone on levels of neuron-specific_enolase in cardiac surgery : a corticosteroid derivative to decrease possible neuronal_damage .
14722324	0	methylprednisolone	50,68	phosphoenolpyruvate_carboxykinase	72,105	methylprednisolone	phosphoenolpyruvate carboxykinase	MESH:D008775	362282(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|regulation regulation|amod|END_ENTITY	Receptor/gene-mediated pharmacodynamic effects of methylprednisolone on phosphoenolpyruvate_carboxykinase regulation in rat liver .
11749774	0	methylprednisolone	11,29	phospholipase_D	47,62	methylprednisolone	phospholipase D	MESH:D008775	2822	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|amod|END_ENTITY	Effects of methylprednisolone and aprotinin on phospholipase_D activity of leukocytes in systemic inflammatory response induced by cardiopulmonary bypass .
10195522	0	methylprednisolone	14,32	tumor_necrosis_factor-alpha	58,85	methylprednisolone	tumor necrosis factor-alpha	MESH:D008775	7124	Chemical	Gene	Prevention|nmod|START_ENTITY increased|nsubj|Prevention increased|xcomp|circulating circulating|dobj|levels levels|amod|END_ENTITY	Prevention by methylprednisolone of increased circulating tumor_necrosis_factor-alpha levels and lung_injury associated with systemic_inflammatory_response_syndrome due to intraperitoneal hyperthermia .
21049601	0	methylprednisolone_sodium_succinate	20,55	nerve_growth_factor	66,85	methylprednisolone sodium succinate	nerve growth factor	MESH:D008776	18049(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nsubj|effect	-LSB- Clinical effect of methylprednisolone_sodium_succinate and mouse nerve_growth_factor for injection in treating acute spinal_cord_injury and cauda_equina_injury -RSB- .
1871327	0	methyltestosterone	14,32	growth_hormone	40,54	methyltestosterone	growth hormone	MESH:D008777	2688	Chemical	Gene	START_ENTITY|nmod|response response|amod|END_ENTITY	The effect of methyltestosterone on the growth_hormone response to the dopamine receptor agonist , apomorphine .
9851788	0	methyltestosterone	11,29	insulin	33,40	methyltestosterone	insulin	MESH:D008777	3630	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of methyltestosterone on insulin secretion and sensitivity in women .
18762716	0	methyltetrahydrofolate	88,110	reduced_folate_carrier_1	15,39	methyltetrahydrofolate	reduced folate carrier 1	CHEBI:25345	29723(Tax:10116)	Chemical	Gene	transport|nmod|START_ENTITY Involvement|nmod|transport Involvement|nmod|END_ENTITY	Involvement of reduced_folate_carrier_1 in the inner blood-retinal barrier transport of methyltetrahydrofolate .
3576094	0	methylthiouracil	34,50	elastin	56,63	methylthiouracil	elastin	MESH:D008779	25043(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|content content|compound|END_ENTITY	Influence of thyroid hormones and methylthiouracil upon elastin content in the liver of rats with carbon_tetrachloride-induced hepatic_fibrosis .
3003588	0	methylxanthine_aminophylline	79,107	prolactin	22,31	methylxanthine aminophylline	prolactin	null	24683(Tax:10116)	Chemical	Gene	Increase|nmod|START_ENTITY Increase|nmod|END_ENTITY	Increase of rat serum prolactin by adenosine analogs and their blockade by the methylxanthine_aminophylline .
8786577	0	methylxanthines	99,114	Tumor_necrosis_factor	0,21	methylxanthines	Tumor necrosis factor	CHEBI:25348	21926(Tax:10090)	Chemical	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Tumor_necrosis_factor production in the perfused mouse liver and its pharmacological modulation by methylxanthines .
9196272	0	methylxanthines	69,84	beta2-adrenoceptor	40,58	methylxanthines	beta2-adrenoceptor	CHEBI:25348	100722663	Chemical	Gene	agonists|appos|START_ENTITY agonists|amod|END_ENTITY	In vitro studies on the interactions of beta2-adrenoceptor agonists , methylxanthines , Ca2 + - channel blockers , K + - channel openers and other airway smooth muscle relaxants in isolated guinea-pig trachea .
3031716	0	methysergide	29,41	Growth_hormone	163,177	methysergide	Growth hormone	MESH:D008784	2688	Chemical	Gene	blockers|dep|START_ENTITY Effect|nmod|blockers Effect|dep|END_ENTITY	Effect of receptor blockers -LRB- methysergide , propranolol , phentolamine , yohimbine and prazosin -RRB- on desimipramine-induced pituitary hormone stimulation in humans -- I. Growth_hormone .
7219880	0	methysergide	35,47	growth_hormone	65,79	methysergide	growth hormone	MESH:D008784	2688	Chemical	Gene	interaction|nmod|START_ENTITY Effects|nmod|interaction Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of the interaction between methysergide and clonidine on growth_hormone and prolactin secretion in normal man .
849986	0	methysergide	10,22	growth_hormone	59,73	methysergide	growth hormone	MESH:D008784	2688	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of methysergide and pimozide on apomorphine-induced growth_hormone secretion in men .
126860	0	methysergide	10,22	prolactin	68,77	methysergide	prolactin	MESH:D008784	24683(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|compound|END_ENTITY	Effect of methysergide , a blocker of serotonin receptors , on plasma prolactin levels in lactating and ovariectomized rats .
3083453	0	methysergide	11,23	prolactin	55,64	methysergide	prolactin	MESH:D008784	5617	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of methysergide , bromocriptine and naloxone on prolactin , growth_hormone and TSH release induced by D-Met2 , Pro5-enkephalinamide in man .
562901	0	methysergide	25,37	prolactin	12,21	methysergide	prolactin	MESH:D008784	5617	Chemical	Gene	Decrease|nmod|START_ENTITY Decrease|nmod|END_ENTITY	Decrease of prolactin by methysergide in amenorrheic hyperprolactinemic women .
7613098	0	methysergide	11,23	prolactin	46,55	methysergide	prolactin	MESH:D008784	5617	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|responses responses|compound|END_ENTITY	Effects of methysergide and ritanserin on the prolactin and thyrotropin responses to TRH in depressed patients .
8434056	0	methysergide	151,163	prolactin	22,31	methysergide	prolactin	MESH:D008784	24683(Tax:10116)	Chemical	Gene	responses|dep|START_ENTITY evidence|dep|responses evidence|dep|modified modified|nsubjpass|secretion secretion|compound|END_ENTITY	Further evidence that prolactin secretion in adult female rats is differently modified after neonatal estrogenization or androgenization : responses to methysergide , quipazine , and pizotifen .
12069	0	metiamide	10,19	cholecystokinin	50,65	metiamide	cholecystokinin	MESH:D008785	885	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|compound|END_ENTITY	Effect of metiamide on basal and stimulated serum cholecystokinin levels in duodenal ulcer patients .
6308452	0	metkephamid	28,39	Met-enkephalin	54,68	metkephamid	Met-enkephalin	MESH:C028208	5443	Chemical	Gene	START_ENTITY|appos|analogue analogue|amod|END_ENTITY	Preclinical pharmacology of metkephamid -LRB- LY127623 -RRB- , a Met-enkephalin analogue .
16167316	0	metoclopramide	10,24	AChE	67,71	metoclopramide	AChE	MESH:D008787	43	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|inhibition inhibition|nmod|END_ENTITY	Effect of metoclopramide and ranitidine on the inhibition of human AChE by VX in vitro .
1832287	0	metoclopramide	35,49	Atrial_natriuretic_factor	0,25	metoclopramide	Atrial natriuretic factor	MESH:D008787	4878	Chemical	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Atrial_natriuretic_factor inhibits metoclopramide stimulated aldosterone release in man .
219871	0	metoclopramide	11,25	GH	45,47	metoclopramide	GH	MESH:D008787	2688	Chemical	Gene	START_ENTITY|nmod|growth_hormone growth_hormone|appos|END_ENTITY	-LSB- Effect of metoclopramide on growth_hormone -LRB- GH -RRB- release induced with ACTH -RSB- .
11561213	0	metoclopramide	45,59	Growth_hormone	0,14	metoclopramide	Growth hormone	MESH:D008787	2688	Chemical	Gene	administration|amod|START_ENTITY secretion|nmod|administration secretion|compound|END_ENTITY	Growth_hormone and prolactin secretion after metoclopramide administration -LRB- DA2 receptor blockade -RRB- in fertile women .
3149100	0	metoclopramide	33,47	Prolactin	1,10	metoclopramide	Prolactin	MESH:D008787	5617	Chemical	Gene	test|amod|START_ENTITY using|dobj|test stimulation|acl|using stimulation|compound|END_ENTITY	-LSB- Prolactin stimulation using the metoclopramide test in females taking oral contraceptives -RSB- .
3168303	0	metoclopramide	22,36	Prolactin	0,9	metoclopramide	Prolactin	MESH:D008787	5617	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Prolactin response to metoclopramide does not distinguish patients with hypogonadotrophic_hypogonadism from delayed puberty .
3839061	0	metoclopramide	65,79	Prolactin	0,9	metoclopramide	Prolactin	MESH:D008787	5617	Chemical	Gene	response|nmod|START_ENTITY secretion|dep|response secretion|compound|END_ENTITY	Prolactin secretion during pregnancy and puerperium : response to metoclopramide and interactions with placental hormones .
6775949	0	metoclopramide	32,46	Prolactin	0,9	metoclopramide	Prolactin	MESH:D008787	5617	Chemical	Gene	agents|compound|START_ENTITY response|nmod|agents response|compound|END_ENTITY	Prolactin response to exercise , metoclopramide and other provacative agents in children .
6790208	0	metoclopramide	22,36	Prolactin	0,9	metoclopramide	Prolactin	MESH:D008787	5617	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Prolactin response to metoclopramide and chlorpromazine in primary testicular_failure and isolated_gonadotrophin_deficiency .
6804483	0	metoclopramide	22,36	Prolactin	0,9	metoclopramide	Prolactin	MESH:D008787	5617	Chemical	Gene	START_ENTITY|nsubj|response response|compound|END_ENTITY	Prolactin response to metoclopramide in hyperthyroidism .
7571	0	metoclopramide	23,37	Prolactin	0,9	metoclopramide	Prolactin	MESH:D008787	5617	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|END_ENTITY	Prolactin secretion by metoclopramide in man .
7823004	0	metoclopramide	83,97	Prolactin	0,9	metoclopramide	Prolactin	MESH:D008787	5617	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|END_ENTITY	Prolactin -LRB- PRL -RRB- release in normal and growth hormone deficient children after oral metoclopramide .
8701791	0	metoclopramide	22,36	Prolactin	0,9	metoclopramide	Prolactin	MESH:D008787	5617	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Prolactin response to metoclopramide and thyrotropin-releasing_hormone in normoprolactinemic and hyperprolactinemic women : a comparison of diagnostic validity .
15374502	0	metoclopramide	89,103	Vasopressin	0,11	metoclopramide	Vasopressin	MESH:D008787	551	Chemical	Gene	stimulation|amod|START_ENTITY evaluation|nmod|stimulation END_ENTITY|dep|evaluation	Vasopressin , prolactin and growth_hormone in Alzheimer 's _ disease : their evaluation after metoclopramide stimulation .
1957561	0	metoclopramide	135,149	cholecystokinin	93,108	metoclopramide	cholecystokinin	MESH:D008787	397468(Tax:9823)	Chemical	Gene	antagonist|appos|START_ENTITY END_ENTITY|nmod|antagonist	Hormonal effects of apomorphine and cholecystokinin in pigs : modification of the response to cholecystokinin by a dopamine antagonist -LRB- metoclopramide -RRB- and a kappa opioid agonist -LRB- PD117302 -RRB- .
11854155	0	metoclopramide	41,55	cytochrome_P450_2D6	88,107	metoclopramide	cytochrome P450 2D6	MESH:D008787	1565	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	The gastroprokinetic and antiemetic drug metoclopramide is a substrate and inhibitor of cytochrome_P450_2D6 .
8230103	0	metoclopramide	65,79	dopamine_D2_receptor	89,109	metoclopramide	dopamine D2 receptor	MESH:D008787	13489(Tax:10090)	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	The interaction of ammonium , sulfonium , and sulfide analogues of metoclopramide with the dopamine_D2_receptor .
1673022	0	metoclopramide	116,130	growth_hormone	63,77	metoclopramide	growth hormone	MESH:D008787	2688	Chemical	Gene	studies|nmod|START_ENTITY Role|dep|studies Role|nmod|pathways pathways|nmod|control control|nmod|secretion secretion|amod|END_ENTITY	Role of central dopaminergic pathways in the neural control of growth_hormone secretion in normal men : studies with metoclopramide .
3266935	0	metoclopramide	109,123	growth_hormone	29,43	metoclopramide	growth hormone	MESH:D008787	2688	Chemical	Gene	corticotropin-releasing_hormone|nmod|START_ENTITY Provocation|acl|corticotropin-releasing_hormone Provocation|nmod|response response|compound|END_ENTITY	Provocation of a paradoxical growth_hormone response to corticotropin-releasing_hormone by pretreatment with metoclopramide in patients with acromegaly and normal subjects .
3830074	0	metoclopramide	31,45	growth_hormone	13,27	metoclopramide	growth hormone	MESH:D008787	2688	Chemical	Gene	Responses|acl|START_ENTITY Responses|nmod|END_ENTITY	Responses of growth_hormone to metoclopramide in normal women and amenorrheic women with or without hyperprolactinemia .
6863846	0	metoclopramide	10,24	growth_hormone	34,48	metoclopramide	growth hormone	MESH:D008787	2688	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of metoclopramide on serum growth_hormone levels in cirrhotic men .
7508379	0	metoclopramide	11,25	growth_hormone	45,59	metoclopramide	growth hormone	MESH:D008787	2688	Chemical	Gene	START_ENTITY|nmod|response response|compound|END_ENTITY	Effects of metoclopramide on the paradoxical growth_hormone response to galanin in acromegaly .
7693566	0	metoclopramide	11,25	growth_hormone	33,47	metoclopramide	growth hormone	MESH:D008787	2688	Chemical	Gene	START_ENTITY|nmod|response response|amod|END_ENTITY	Effects of metoclopramide on the growth_hormone response to galanin in normal man .
3965339	0	metoclopramide	109,123	motilin	7,14	metoclopramide	motilin	MESH:D008787	4295	Chemical	Gene	effect|nmod|START_ENTITY concentration|dep|effect concentration|compound|END_ENTITY	Plasma motilin concentration and interdigestive migrating motor complex in diabetic_gastroparesis : effect of metoclopramide .
10732318	0	metoclopramide	52,66	prolactin	30,39	metoclopramide	prolactin	MESH:D008787	5617	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Effect of parity on pituitary prolactin response to metoclopramide and domperidone : implications for the enhancement of lactation .
112817	0	metoclopramide	14,28	prolactin	48,57	metoclopramide	prolactin	MESH:D008787	5617	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|compound|END_ENTITY	The effect of metoclopramide , TRH and L-dopa on prolactin secretion in pituitary_adenoma and in `` functional '' galactorrhoea syndrome .
12351372	0	metoclopramide	39,53	prolactin	79,88	metoclopramide	prolactin	MESH:D008787	5617	Chemical	Gene	Response|acl|START_ENTITY Response|dep|evidence evidence|nmod|role role|nmod|END_ENTITY	Response of Diamond-Blackfan_anemia to metoclopramide : evidence for a role for prolactin in erythropoiesis .
1527538	0	metoclopramide	28,42	prolactin	6,15	metoclopramide	prolactin	MESH:D008787	5617	Chemical	Gene	Serum|xcomp|START_ENTITY Serum|dobj|response response|compound|END_ENTITY	Serum prolactin response to metoclopramide during status_epilepticus .
1573708	0	metoclopramide	11,25	prolactin	49,58	metoclopramide	prolactin	MESH:D008787	5617	Chemical	Gene	START_ENTITY|nmod|concentrations concentrations|compound|END_ENTITY	Effects of metoclopramide and quipazine on serum prolactin concentrations in steers .
2022267	0	metoclopramide	40,54	prolactin	13,22	metoclopramide	prolactin	MESH:D008787	5617	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Differential prolactin response to oral metoclopramide in nulliparous versus parous women throughout the menstrual cycle .
3974416	0	metoclopramide	67,81	prolactin	14,23	metoclopramide	prolactin	MESH:D008787	5617	Chemical	Gene	Variations|nmod|START_ENTITY Variations|nmod|content content|compound|END_ENTITY	Variations of prolactin content in human cerebrospinal fluid after metoclopramide and morphine .
553575	0	metoclopramide	29,43	prolactin	54,63	metoclopramide	prolactin	MESH:D008787	5617	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|response response|compound|END_ENTITY	-LSB- Effect of pretreatment with metoclopramide on plasma prolactin response to methergoline -RSB- .
557389	0	metoclopramide	49,63	prolactin	19,28	metoclopramide	prolactin	MESH:D008787	5617	Chemical	Gene	test|amod|START_ENTITY value|nmod|test value|nmod|END_ENTITY	-LSB- Standard value of prolactin and significance of metoclopramide test , with special reference to normal subjects and patients with thyroid_diseases -RSB- .
590923	0	metoclopramide	10,24	prolactin	28,37	metoclopramide	prolactin	MESH:D008787	5617	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of metoclopramide on prolactin secretion in man .
6203986	0	metoclopramide	80,94	prolactin	24,33	metoclopramide	prolactin	MESH:D008787	5617	Chemical	Gene	Increased|nmod|START_ENTITY Increased|dobj|secretion secretion|nmod|END_ENTITY	-LSB- Increased secretion of prolactin after inhibition of dopaminergic receptors by metoclopramide in patients with cancer of the prostate -RSB- .
6421192	0	metoclopramide	45,59	prolactin	15,24	metoclopramide	prolactin	MESH:D008787	5617	Chemical	Gene	stimulation|amod|START_ENTITY serum|nmod|stimulation serum|dobj|concentration concentration|compound|END_ENTITY	Enhanced serum prolactin concentration after metoclopramide stimulation in idiopathic oligozoospermia and azoospermia .
6730927	0	metoclopramide	49,63	prolactin	10,19	metoclopramide	prolactin	MESH:D008787	5617	Chemical	Gene	Preserved|xcomp|START_ENTITY Preserved|dobj|fluctuations fluctuations|compound|END_ENTITY	Preserved prolactin fluctuations and response to metoclopramide in ovulatory , infertile , hyperprolactinemic women .
6771199	0	metoclopramide	65,79	prolactin	43,52	metoclopramide	prolactin	MESH:D008787	5617	Chemical	Gene	Dose-dependency|acl|START_ENTITY Dose-dependency|nmod|response response|compound|END_ENTITY	Dose-dependency and reproducibility of the prolactin response to metoclopramide .
7002371	0	metoclopramide	26,40	prolactin	4,13	metoclopramide	prolactin	MESH:D008787	5617	Chemical	Gene	response|acl|START_ENTITY response|compound|END_ENTITY	The prolactin response to metoclopramide in growth_hormone deficient adolescent males .
7069345	0	metoclopramide	11,25	prolactin	47,56	metoclopramide	prolactin	MESH:D008787	5617	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of metoclopramide and bromocriptine on prolactin secretion in the pregnant ewe .
7169099	0	metoclopramide	16,30	prolactin	73,82	metoclopramide	prolactin	MESH:D008787	5617	Chemical	Gene	effects|nmod|START_ENTITY -LSB-|dobj|effects -LSB-|nmod|END_ENTITY	-LSB- The effects of metoclopramide on maternal , umbilical and amniotic fluid prolactin at delivery -RSB- .
7270091	0	metoclopramide	20,34	prolactin	45,54	metoclopramide	prolactin	MESH:D008787	5617	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nsubj|effect	The acute effect of metoclopramide on plasma prolactin during pregnancy .
777023	4	metoclopramide	708,722	prolactin	786,795	metoclopramide	prolactin	MESH:D008787	5617	Chemical	Gene	acts|nsubj|START_ENTITY acts|advcl|inhibiting inhibiting|dobj|secretion secretion|nmod|factor factor|amod|END_ENTITY	Pre-treatment with 500 mg L-dopa inhibited the early metoclopramide-induced prolactin increase , which is consistent with the possibility that metoclopramide acts by inhibiting dopamine-mediated hypothalamic secretion of prolactin inhibitory factor .
821965	0	metoclopramide	14,28	prolactin	57,66	metoclopramide	prolactin	MESH:D008787	5617	Chemical	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|secretion secretion|compound|END_ENTITY	Comparison of metoclopramide with other dynamic tests of prolactin secretion .
847008	0	metoclopramide	38,52	prolactin	15,24	metoclopramide	prolactin	MESH:D008787	24683(Tax:10116)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Stimulation Stimulation|nmod|END_ENTITY	Stimulation of prolactin secretion by metoclopramide in the rat .
8498149	0	metoclopramide	54,68	prolactin	132,141	metoclopramide	prolactin	MESH:D008787	5617	Chemical	Gene	START_ENTITY|nmod|subjects subjects|nmod|END_ENTITY	Different responses in little and bigbig prolactin to metoclopramide in subjects with hyperprolactinemia due to 150-170 kD -LRB- bigbig -RRB- prolactin .
8498149	0	metoclopramide	54,68	prolactin	41,50	metoclopramide	prolactin	MESH:D008787	5617	Chemical	Gene	responses|acl|START_ENTITY responses|nmod|END_ENTITY	Different responses in little and bigbig prolactin to metoclopramide in subjects with hyperprolactinemia due to 150-170 kD -LRB- bigbig -RRB- prolactin .
8737186	0	metoclopramide	87,101	prolactin	59,68	metoclopramide	prolactin	MESH:D008787	5617	Chemical	Gene	responsiveness|xcomp|START_ENTITY responsiveness|nsubj|difference difference|nmod|- -|nmod|END_ENTITY	No difference between micro - and macroprolactinomas in the prolactin responsiveness to metoclopramide and dopamine administration .
908151	0	metoclopramide	62,76	prolactin	10,19	metoclopramide	prolactin	MESH:D008787	5617	Chemical	Gene	secretion|dobj|START_ENTITY secretion|nsubj|END_ENTITY	Increased prolactin and thyrotrophin secretion following oral metoclopramide : dose-response relationships .
6361937	0	metoclopramide	14,28	renin	55,60	metoclopramide	renin	MESH:D008787	24715(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|compound|END_ENTITY	The effect of metoclopramide and haloperidol on plasma renin activity and aldosterone levels in rats .
1316710	0	metoclopramide	32,46	vasopressin	8,19	metoclopramide	vasopressin	MESH:D008787	551	Chemical	Gene	response|acl|START_ENTITY response|amod|END_ENTITY	Altered vasopressin response to metoclopramide in multiple system atrophy : evidence of a cholinergic_defect_in_the_hypothalamus .
3680481	0	metoclopramide	80,94	vasopressin	34,45	metoclopramide	vasopressin	MESH:D008787	551	Chemical	Gene	effect|nmod|START_ENTITY control|dep|effect control|nmod|release release|compound|END_ENTITY	Osmotic and nonosmotic control of vasopressin release in the elderly : effect of metoclopramide .
6467638	0	metoclopramide	10,24	vasopressin	35,46	metoclopramide	vasopressin	MESH:D008787	551	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of metoclopramide in plasma vasopressin in man .
25181459	0	metolazone	28,38	pregnane_X_receptor	55,74	metolazone	pregnane X receptor	MESH:D008788	8856	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Thiazide-like diuretic drug metolazone activates human pregnane_X_receptor to induce cytochrome 3A4 and multidrug-resistance_protein_1 .
849995	0	metolazone	50,60	renin	21,26	metolazone	renin	MESH:D008788	5972	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|dobj|effects	Antihypertensive and renin angiotensin effects of metolazone with and without propranolol .
18384443	0	metoprolol	56,66	CYP2D6	70,76	metoprolol	CYP2D6	MESH:D008790	1565	Chemical	Gene	START_ENTITY|appos|substrate substrate|compound|END_ENTITY	Effects of imatinib -LRB- Glivec -RRB- on the pharmacokinetics of metoprolol , a CYP2D6 substrate , in Chinese patients with chronic_myelogenous_leukaemia .
18545991	0	metoprolol	36,46	CYP2D6	50,56	metoprolol	CYP2D6	MESH:D008790	1565	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY pharmacokinetics|nmod|metabolizers metabolizers|nummod|END_ENTITY	Enantiospecific pharmacokinetics of metoprolol in CYP2D6 ultra-rapid metabolizers and correlation with exercise-induced heart rate .
18834373	0	metoprolol	50,60	CYP2D6	13,19	metoprolol	CYP2D6	MESH:D008790	1565	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY *|nmod|pharmacokinetics *|nsubj|Influence Influence|nmod|END_ENTITY	Influence of CYP2D6 * 10 on the pharmacokinetics of metoprolol in healthy Korean volunteers .
20501412	0	metoprolol	11,21	GRK2	43,47	metoprolol	GRK2	MESH:D008790	156	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of metoprolol on the expression of GRK2 in lymphocyte of advanced elderly patients with chronic_heart_failure -RSB- .
3093	0	metoprolol	14,24	adrenergic_beta1-receptor	43,68	metoprolol	adrenergic beta1-receptor	MESH:D008790	153	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|END_ENTITY	The effect of metoprolol -- a new selective adrenergic_beta1-receptor blocking agent -- in mild hypertension .
33811	0	metoprolol	127,137	beta1-adrenoceptor	61,79	metoprolol	beta1-adrenoceptor	MESH:D008790	153	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|agonist agonist|amod|END_ENTITY	Haemodynamic effects and pharmacokinetics of a new selective beta1-adrenoceptor agonist , prenalterol , and its interaction with metoprolol in man .
2574052	0	metoprolol	97,107	beta_1-adrenoceptor	54,73	metoprolol	beta 1-adrenoceptor	MESH:D008790	153	Chemical	Gene	antagonists|dep|START_ENTITY antagonists|amod|END_ENTITY	CNS-related subjective symptoms during treatment with beta_1-adrenoceptor antagonists -LRB- atenolol , metoprolol -RRB- : two double-blind placebo controlled studies .
3023226	0	metoprolol	122,132	beta_1-adrenoceptor	88,107	metoprolol	beta 1-adrenoceptor	MESH:D008790	153	Chemical	Gene	blockade|nmod|START_ENTITY blockade|amod|END_ENTITY	Plasma renin activity , active and inactive renin concentrations , and their responses to beta_1-adrenoceptor blockade with metoprolol in hyperthyroidism .
1233219	0	metoprolol	11,21	renin	63,68	metoprolol	renin	MESH:D008790	5972	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|release release|compound|END_ENTITY	Effects of metoprolol and propranolol on furosemide-stimulated renin release in healthy subjects .
3023226	0	metoprolol	122,132	renin	7,12	metoprolol	renin	MESH:D008790	5972	Chemical	Gene	blockade|nmod|START_ENTITY END_ENTITY|nmod|blockade	Plasma renin activity , active and inactive renin concentrations , and their responses to beta_1-adrenoceptor blockade with metoprolol in hyperthyroidism .
16596028	0	metoprolol_succinate	31,51	C-reactive_protein	55,73	metoprolol succinate	C-reactive protein	MESH:C402833	1401	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|levels levels|amod|END_ENTITY	The effect of extended-release metoprolol_succinate on C-reactive_protein levels in persons with hypertension .
953462	0	metramide	14,23	gastrin	47,54	metramide	gastrin	null	2520	Chemical	Gene	START_ENTITY|nmod|response response|compound|END_ENTITY	The effect of metramide on the prolonged serum gastrin response to feeding observed in patients with duodenal ulcer .
7501282	0	metrazole	92,101	c-fos	27,32	metrazole	c-fos	MESH:D010433	314322(Tax:10116)	Chemical	Gene	proenkephalin_and_tyrosine_hydroxylase|nmod|START_ENTITY proenkephalin_and_tyrosine_hydroxylase|nsubj|regulation regulation|nmod|END_ENTITY	Differential regulation of c-fos , proenkephalin_and_tyrosine_hydroxylase gene expression by metrazole in the hamster adrenal and hippocampus .
1009679	0	metroclopramide	10,25	prolactin	35,44	metroclopramide	prolactin	null	5617	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|compound|END_ENTITY	Effect of metroclopramide on serum prolactin levels in humans .
6612225	0	metronidazole	11,24	ASAT	64,68	metronidazole	ASAT	MESH:D008795	22	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of metronidazole -LRB- Flagyl -RRB- on the determination of serum ASAT on the SMA 12/60 Auto Analyser .
11601665	0	metronidazole	11,24	CYP3A4	36,42	metronidazole	CYP3A4	MESH:D008795	1576	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|compound|END_ENTITY	Effects of metronidazole on hepatic CYP3A4 activity .
4320226	0	metronidazole	10,23	alcohol_dehydrogenase	33,54	metronidazole	alcohol dehydrogenase	MESH:D008795	10327	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of metronidazole on liver alcohol_dehydrogenase .
7626074	0	metronidazole	42,55	diamine_oxidase	14,29	metronidazole	diamine oxidase	MESH:D008795	26	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activity activity|amod|END_ENTITY	Inhibition of diamine_oxidase activity by metronidazole .
10931104	0	metyrapone	72,82	ACTH	13,17	metyrapone	ACTH	MESH:D008797	5443	Chemical	Gene	test|compound|START_ENTITY sensitive|nmod|test sensitive|nsubj|test test|compound|END_ENTITY	The low dose ACTH stimulation test is less sensitive than the overnight metyrapone test for the diagnosis of secondary hypoadrenalism .
168228	0	metyrapone	52,62	ACTH	14,18	metyrapone	ACTH	MESH:D008797	5443	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|response response|compound|END_ENTITY	Inhibition of ACTH response to oral and intravenous metyrapone by antiserotoninergic treatment in man .
16824495	0	metyrapone	44,54	ACTH	23,27	metyrapone	ACTH	MESH:D008797	5443	Chemical	Gene	START_ENTITY|nsubj|differences differences|nmod|response response|compound|END_ENTITY	Sex differences in the ACTH response to 24H metyrapone in depression .
225068	0	metyrapone	10,20	ACTH	52,56	metyrapone	ACTH	MESH:D008797	5443	Chemical	Gene	test|compound|START_ENTITY test|dep|comparison comparison|nmod|response response|compound|END_ENTITY	The short metyrapone test : comparison of the plasma ACTH response to metyrapone and insulin-induced hypoglycaemia .
225068	0	metyrapone	69,79	ACTH	52,56	metyrapone	ACTH	MESH:D008797	5443	Chemical	Gene	hypoglycaemia|amod|START_ENTITY response|nmod|hypoglycaemia response|compound|END_ENTITY	The short metyrapone test : comparison of the plasma ACTH response to metyrapone and insulin-induced hypoglycaemia .
26859587	0	metyrapone	25,35	ACTH	82,86	metyrapone	ACTH	MESH:D008797	5443	Chemical	Gene	description|nmod|START_ENTITY use|nsubj|description use|nmod|END_ENTITY	The first description of metyrapone use in severe Cushing_Syndrome due to ectopic ACTH secretion in an infant with immature sacrococcygeal teratoma .
2852510	0	metyrapone	75,85	ACTH	12,16	metyrapone	ACTH	MESH:D008797	5443	Chemical	Gene	pretreatment|amod|START_ENTITY avoided|nmod|pretreatment avoided|nsubjpass|Blunting Blunting|nmod|response response|amod|END_ENTITY	Blunting of ACTH response to human CRH in depressed patients is avoided by metyrapone pretreatment .
6251560	0	metyrapone	32,42	ACTH	1,5	metyrapone	ACTH	MESH:D008797	5443	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	-LSB- ACTH response to 24 hours oral metyrapone test in normal children -LRB- author 's transl -RRB- -RSB- .
6273024	0	metyrapone	10,20	ACTH	52,56	metyrapone	ACTH	MESH:D008797	5443	Chemical	Gene	test|amod|START_ENTITY test|dep|comparison comparison|nmod|response response|compound|END_ENTITY	The short metyrapone test : comparison of the plasma ACTH response to metyrapone with the cortisol response to insulin-induced hypoglycaemia in patients with pituitary_disease .
6273024	0	metyrapone	69,79	ACTH	52,56	metyrapone	ACTH	MESH:D008797	5443	Chemical	Gene	response|acl|START_ENTITY response|compound|END_ENTITY	The short metyrapone test : comparison of the plasma ACTH response to metyrapone with the cortisol response to insulin-induced hypoglycaemia in patients with pituitary_disease .
1490094	0	metyrapone	28,38	Beta-endorphin	0,14	metyrapone	Beta-endorphin	MESH:D008797	5443	Chemical	Gene	responses|nmod|START_ENTITY responses|amod|END_ENTITY	Beta-endorphin responses to metyrapone and dexamethasone in depressed patients .
8948014	0	metyrapone	87,97	CYP2B1	63,69	metyrapone	CYP2B1	MESH:D008797	24300(Tax:10116)	Chemical	Gene	induction|nmod|START_ENTITY induction|appos|END_ENTITY	Differential induction of mRNA expression of cytochromes P450 -LRB- CYP2B1 and CYP1A1/2 -RRB- by metyrapone in primary rat hepatocyte cultures .
4037796	0	metyrapone	26,36	Cytochrome_P-450	0,16	metyrapone	Cytochrome P-450	MESH:D008797	25251(Tax:10116)	Chemical	Gene	ligands|dep|START_ENTITY ligands|amod|END_ENTITY	Cytochrome_P-450 ligands : metyrapone revisited .
187090	0	metyrapone	11,21	IgG	81,84	metyrapone	IgG	MESH:D008797	102658792	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of metyrapone and ACTH on intestinal absorption of immunoreactive bovine IgG in cesarean-derived pigs .
219030	0	metyrapone	137,147	beta-endorphin	27,41	metyrapone	beta-endorphin	MESH:D008797	5443	Chemical	Gene	administration|amod|START_ENTITY adrenocorticotropin|nmod|administration beta-endorphin|nmod|adrenocorticotropin release|nmod|beta-endorphin Presence|dep|release Presence|nmod|END_ENTITY	Presence of immunoreactive beta-endorphin in normal human plasma : a concomitant release of beta-endorphin with adrenocorticotropin after metyrapone administration .
219030	0	metyrapone	137,147	beta-endorphin	91,105	metyrapone	beta-endorphin	MESH:D008797	5443	Chemical	Gene	administration|amod|START_ENTITY adrenocorticotropin|nmod|administration END_ENTITY|nmod|adrenocorticotropin	Presence of immunoreactive beta-endorphin in normal human plasma : a concomitant release of beta-endorphin with adrenocorticotropin after metyrapone administration .
1471455	0	metyrapone	11,21	corticotropin-releasing_factor	34,64	metyrapone	corticotropin-releasing factor	MESH:D008797	1392	Chemical	Gene	infusion|amod|START_ENTITY infusion|nmod|END_ENTITY	Effects of metyrapone infusion on corticotropin-releasing_factor and arginine_vasopressin secretion into the hypophysial portal blood of conscious , unrestrained rams .
10611146	0	metyrapone	52,62	cytochrome_P-450	122,138	metyrapone	cytochrome P-450	MESH:D008797	4051	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|induction induction|nmod|3A4 3A4|amod|END_ENTITY	Effect of the adrenal 11-beta-hydroxylase inhibitor metyrapone on human hepatic cytochrome_P-450 expression : induction of cytochrome_P-450 3A4 .
10611146	0	metyrapone	52,62	cytochrome_P-450	80,96	metyrapone	cytochrome P-450	MESH:D008797	4051	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effect of the adrenal 11-beta-hydroxylase inhibitor metyrapone on human hepatic cytochrome_P-450 expression : induction of cytochrome_P-450 3A4 .
182488	0	metyrapone	13,23	cytochrome_P-450	49,65	metyrapone	cytochrome P-450	MESH:D008797	4051	Chemical	Gene	spin|amod|START_ENTITY Binding|nmod|spin label|nsubj|Binding label|xcomp|microsomal microsomal|xcomp|END_ENTITY	Binding of a metyrapone spin label to microsomal cytochrome_P-450 .
2339981	1	metyrapone	141,151	cytochrome_P-450	175,191	metyrapone	cytochrome P-450	MESH:D008797	25251(Tax:10116)	Chemical	Gene	ability|nmod|START_ENTITY Relevance|nmod|ability Relevance|xcomp|prevent prevent|dobj|loss loss|nmod|culture culture|amod|END_ENTITY	Relevance to the ability of metyrapone to prevent the loss of cytochrome_P-450 in rat hepatocyte culture .
4851681	0	metyrapone	109,119	cytochrome_P-450	139,155	metyrapone	cytochrome P-450	MESH:D008797	4051	Chemical	Gene	vitro|nmod|START_ENTITY END_ENTITY|amod|vitro	Effect of phenobarbital and 3-methylcholanthrene administration in vivo and isooctane extraction in vitro on metyrapone binding to reduced cytochrome_P-450 .
7150369	0	metyrapone	11,21	cytochrome_P-450	44,60	metyrapone	cytochrome P-450	MESH:D008797	25251(Tax:10116)	Chemical	Gene	dithionite-reduced|amod|START_ENTITY END_ENTITY|amod|dithionite-reduced	Binding of metyrapone to dithionite-reduced cytochrome_P-450 from rats treated with xenobiotics .
10751437	0	mevalonate	47,57	3-hydroxy-3-methylglutaryl-CoA_reductase	169,209	mevalonate	3-hydroxy-3-methylglutaryl-CoA reductase	MESH:D008798	25675(Tax:10116)	Chemical	Gene	cascade|amod|START_ENTITY isoprenoid|nmod|cascade Geranylgeranyl-pyrophosphate|appos|isoprenoid compound|nsubj|Geranylgeranyl-pyrophosphate compound|nmod|primary primary|acl|cultured cultured|advcl|protect protect|dobj|death death|acl|induced induced|nmod|inhibition inhibition|amod|END_ENTITY	Geranylgeranyl-pyrophosphate , an isoprenoid of mevalonate cascade , is a critical compound for rat primary cultured cortical neurons to protect the cell death induced by 3-hydroxy-3-methylglutaryl-CoA_reductase inhibition .
4065145	0	mevalonate	14,24	3-hydroxy-3-methylglutaryl-CoA_reductase	28,68	mevalonate	3-hydroxy-3-methylglutaryl-CoA reductase	MESH:D008798	3156	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	The effect of mevalonate on 3-hydroxy-3-methylglutaryl-CoA_reductase activity and the absolute rate of cholesterol biosynthesis in human monocyte-derived macrophages .
1636694	0	mevalonate	65,75	GH	8,10	mevalonate	GH	MESH:D008798	2688	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of GH in regulating nocturnal rates of lipolysis and plasma mevalonate levels in normal and diabetic humans .
3733706	1	mevalonate_carbon	154,171	3-hydroxy-3-methylglutaryl_coenzyme_A_reductase	86,133	mevalonate carbon	3-hydroxy-3-methylglutaryl coenzyme A reductase	null	42803(Tax:7227)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|activity activity|amod|END_ENTITY	Possible regulation of 3-hydroxy-3-methylglutaryl_coenzyme_A_reductase activity by shunted mevalonate_carbon .
2725293	0	mevalonic_acid	68,82	familial_hypercholesterolemia	127,156	mevalonic acid	familial hypercholesterolemia	MESH:D008798	3949	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	Reduction in plasma low-density lipoprotein cholesterol and urinary mevalonic_acid by lovastatin in patients with heterozygous familial_hypercholesterolemia .
3850904	0	mevinolin	54,63	3-hydroxy-3-methylglutaryl-coenzyme_A_reductase	92,139	mevinolin	3-hydroxy-3-methylglutaryl-coenzyme A reductase	MESH:D008148	15357(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Suppression of murine neuroblastoma growth in vivo by mevinolin , a competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme_A_reductase .
19789372	0	mexiletine	11,21	CYP1A2	25,31	mexiletine	CYP1A2	MESH:D008801	1544	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Effects of mexiletine , a CYP1A2 inhibitor , on tizanidine pharmacokinetics and pharmacodynamics .
9690950	0	mexiletine	25,35	CYP1A2	15,21	mexiletine	CYP1A2	MESH:D008801	1544	Chemical	Gene	metabolism|amod|START_ENTITY Involvement|nmod|metabolism Involvement|nmod|END_ENTITY	Involvement of CYP1A2 in mexiletine metabolism .
26718213	12	miR-214	1512,1519	sema_4D	1479,1486	miR-214	miR-214	null	406996	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Therefore , the data also demonstrated that sema_4D was the direct target of miR-214 and was negatively regulated by miR-214 in ovarian_cancer cells .
9408809	0	mianserin	49,58	CYP2D6	4,10	mianserin	CYP2D6	MESH:D008803	1565	Chemical	Gene	genotype|nmod|START_ENTITY genotype|compound|END_ENTITY	The CYP2D6 genotype and plasma concentrations of mianserin enantiomers in relation to therapeutic response to mianserin in depressed Japanese patients .
14517191	0	mibefradil	10,20	CYP3A4	24,30	mibefradil	CYP3A4	MESH:D020748	1576	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of mibefradil on CYP3A4 in vivo .
18411403	0	mibefradil	121,131	CYP3A4	98,104	mibefradil	CYP3A4	MESH:D020748	1576	Chemical	Gene	exhibits|nmod|START_ENTITY exhibits|dobj|inhibition inhibition|compound|END_ENTITY	The mibefradil derivative NNC55-0396 , a specific T-type calcium channel antagonist , exhibits less CYP3A4 inhibition than mibefradil .
18411403	0	mibefradil	4,14	CYP3A4	98,104	mibefradil	CYP3A4	MESH:D020748	1576	Chemical	Gene	NNC55-0396|amod|START_ENTITY exhibits|nsubj|NNC55-0396 exhibits|dobj|inhibition inhibition|compound|END_ENTITY	The mibefradil derivative NNC55-0396 , a specific T-type calcium channel antagonist , exhibits less CYP3A4 inhibition than mibefradil .
2410244	0	mibolerone	11,21	androgen_receptor	25,42	mibolerone	androgen receptor	MESH:C100075	367	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of mibolerone to androgen_receptor of benign hypertrophic human prostate .
3265669	0	mibolerone	37,47	androgen_receptor	51,68	mibolerone	androgen receptor	MESH:C100075	367	Chemical	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|END_ENTITY	-LSB- Comparison of the binding nature of mibolerone to androgen_receptor of human prostate with that of R1881 -RSB- .
17175357	0	micafungin	53,63	CYP3A4	19,25	micafungin	CYP3A4	MESH:C121905	1576	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|compound|END_ENTITY	Effects of hepatic CYP3A4 activity on disposition of micafungin in liver transplant recipients with markedly small-for-size grafts .
15969931	0	micafungin	10,20	cytochrome_P450_3A4	24,43	micafungin	cytochrome P450 3A4	MESH:C121905	1576	Chemical	Gene	START_ENTITY|nmod|activities activities|amod|END_ENTITY	Effect of micafungin on cytochrome_P450_3A4 and multidrug_resistance_protein_1 activities , and its comparison with azole antifungal drugs .
21783489	0	microcystin	47,58	vasopressin	62,73	microcystin	vasopressin	MESH:C078588	551	Chemical	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|END_ENTITY	Comparison of the structure of key variants of microcystin to vasopressin .
19124144	0	microcystin-LR	11,25	P-glycoprotein	47,61	microcystin-LR	P-glycoprotein	MESH:C057862	5243	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of microcystin-LR on the expression of P-glycoprotein in Jenynsia multidentata .
15922382	0	microcystin-LR	52,66	p53	22,25	microcystin-LR	p53	MESH:C057862	301300(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|expression expression|nmod|END_ENTITY	Altered expression of p53 , Bcl-2 and Bax induced by microcystin-LR in vivo and in vitro .
22135143	0	microcystin-LR	10,24	phosphatase_2A	36,50	microcystin-LR	phosphatase 2A	MESH:C057862	5524	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of microcystin-LR on protein phosphatase_2A and its function in human amniotic epithelial cells .
12760790	0	microcystins	12,24	c-fos	58,63	microcystins	c-fos	MESH:D052998	314322(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Effects of microcystins on cell cycle and expressions of c-fos and c-jun -RSB- .
12630977	0	midazolam	24,33	CYP3A	12,17	midazolam	CYP3A	MESH:D008874	1576	Chemical	Gene	using|dobj|START_ENTITY END_ENTITY|acl|using	Phenotyping CYP3A using midazolam in cancer and noncancer Asian patients .
10460064	0	midazolam	36,45	CYP3A4	60,66	midazolam	CYP3A4	MESH:D008874	1576	Chemical	Gene	clearance|nmod|START_ENTITY decreases|dobj|clearance decreases|advcl|inhibiting inhibiting|dobj|END_ENTITY	Propofol decreases the clearance of midazolam by inhibiting CYP3A4 : an in vivo and in vitro study .
10562786	0	midazolam	32,41	CYP3A4	69,75	midazolam	CYP3A4	MESH:D008874	1576	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|dep|inhibition inhibition|nmod|END_ENTITY	Fentanyl inhibits metabolism of midazolam : competitive inhibition of CYP3A4 in vitro .
11012556	0	midazolam	120,129	CYP3A4	89,95	midazolam	CYP3A4	MESH:D008874	1576	Chemical	Gene	measured|nmod|START_ENTITY Effect|dep|measured Effect|nmod|activity activity|compound|END_ENTITY	Effect of an oral contraceptive preparation containing ethinylestradiol and gestodene on CYP3A4 activity as measured by midazolam 1 ' - hydroxylation .
12065767	0	midazolam	78,87	CYP3A4	17,23	midazolam	CYP3A4	MESH:D008874	1576	Chemical	Gene	metabolism|compound|START_ENTITY Co-regulation|nmod|metabolism Co-regulation|nmod|END_ENTITY	Co-regulation of CYP3A4 and CYP3A5 and contribution to hepatic and intestinal midazolam metabolism .
12610745	0	midazolam	138,147	CYP3A4	151,157	midazolam	CYP3A4	MESH:D008874	1576	Chemical	Gene	START_ENTITY|appos|substrate substrate|compound|END_ENTITY	A clinical study investigating the pharmacokinetic interaction between NN703 -LRB- tabimorelin -RRB- , a potential inhibitor of CYP3A4 activity , and midazolam , a CYP3A4 substrate .
12920166	0	midazolam	92,101	CYP3A4	64,70	midazolam	CYP3A4	MESH:D008874	1576	Chemical	Gene	analysis|dep|START_ENTITY analysis|nmod|interactions interactions|nmod|substrates substrates|compound|END_ENTITY	Multisite kinetic analysis of interactions between prototypical CYP3A4 subgroup substrates : midazolam , testosterone , and nifedipine .
14515058	0	midazolam	109,118	CYP3A4	43,49	midazolam	CYP3A4	MESH:D008874	1576	Chemical	Gene	metabolism|nmod|START_ENTITY variants|nmod|metabolism variants|nsubj|associations associations|nmod|END_ENTITY	Genotype-phenotype associations for common CYP3A4 and CYP3A5 variants in the basal and induced metabolism of midazolam in European - and African-American men and women .
15114431	0	midazolam	20,29	CYP3A4	33,39	midazolam	CYP3A4	MESH:D008874	1576	Chemical	Gene	Pharmacokinetics|nmod|START_ENTITY Pharmacokinetics|nmod|subjects subjects|amod|END_ENTITY	Pharmacokinetics of midazolam in CYP3A4 - and CYP3A5-genotyped subjects .
15618727	0	midazolam	145,154	CYP3A4	61,67	midazolam	CYP3A4	MESH:D008874	1576	Chemical	Gene	drugs|appos|START_ENTITY method|nmod|drugs testosterone|nsubj|method LCMS/MS|xcomp|testosterone LCMS/MS|nsubj|profiles profiles|nmod|drugs drugs|nmod|activity activity|nummod|END_ENTITY	Substrate dependent inhibition profiles of fourteen drugs on CYP3A4 activity measured by a high throughput LCMS/MS method with four probe drugs , midazolam , testosterone , nifedipine and terfenadine .
15817670	1	midazolam	179,188	CYP3A4	213,219	midazolam	CYP3A4	MESH:D008874	1576	Chemical	Gene	metabolism|nmod|START_ENTITY exhibit|dobj|metabolism exhibit|nmod|cytochrome_P450_3A4 cytochrome_P450_3A4|appos|END_ENTITY	Previously , a human CYP3A4-transgenic -LRB- Tg-CYP3A4 -RRB- mouse line was reported to exhibit enhanced metabolism of midazolam by cytochrome_P450_3A4 -LRB- CYP3A4 -RRB- expressed in small intestine .
16243813	0	midazolam	112,121	CYP3A4	17,23	midazolam	CYP3A4	MESH:D008874	1576	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY variants|nmod|pharmacokinetics variants|nsubj|Effect Effect|nmod|END_ENTITY	Effect of common CYP3A4 and CYP3A5 variants on the pharmacokinetics of the cytochrome P450 3A phenotyping probe midazolam in cancer patients .
16245930	0	midazolam	23,32	CYP3A4	87,93	midazolam	CYP3A4	MESH:D008874	1576	Chemical	Gene	Cooperative|nmod|START_ENTITY Cooperative|nmod|site site|compound|END_ENTITY	Cooperative binding of midazolam with testosterone and alpha-naphthoflavone within the CYP3A4 active site : a NMR T1 paramagnetic relaxation study .
17495418	0	midazolam	190,199	CYP3A4	148,154	midazolam	CYP3A4	MESH:D008874	1576	Chemical	Gene	labeled|dobj|START_ENTITY -RSB-|acl|labeled inhibition|nmod|-RSB- Effect|acl|inhibition Effect|nmod|END_ENTITY	Effect of ion suppression on judgment of enzyme inhibition and avoidance of error by utilizing a stable isotope-labeled probe substrate : example of CYP3A4 inhibition with -LSB- 13C4 ,15 N -RSB- labeled midazolam as a substrate .
17724065	0	midazolam	111,120	CYP3A4	4,10	midazolam	CYP3A4	MESH:D008874	1576	Chemical	Gene	disposition|compound|START_ENTITY affect|dobj|disposition affect|nsubj|allele allele|compound|END_ENTITY	The CYP3A4 * 18 allele , the most frequent coding variant in asian populations , does not significantly affect the midazolam disposition in heterozygous individuals .
17971810	0	midazolam	112,121	CYP3A4	56,62	midazolam	CYP3A4	MESH:D008874	1576	Chemical	Gene	substrates|dobj|START_ENTITY substrates|nsubj|Pharmacodynamics Pharmacodynamics|nmod|induction induction|nmod|END_ENTITY	Pharmacodynamics of carbamazepine-mediated induction of CYP3A4 , CYP1A2 , and Pgp as assessed by probe substrates midazolam , caffeine , and digoxin .
18362694	0	midazolam	92,101	CYP3A4	63,69	midazolam	CYP3A4	MESH:D008874	1576	Chemical	Gene	substrates|dobj|START_ENTITY substrates|nsubj|effect effect|nmod|AMD070 AMD070|nmod|END_ENTITY	Pharmacokinetic effect of AMD070 , an Oral CXCR4 antagonist , on CYP3A4 and CYP2D6 substrates midazolam and dextromethorphan in healthy volunteers .
19255940	0	midazolam	70,79	CYP3A4	31,37	midazolam	CYP3A4	MESH:D008874	1576	Chemical	Gene	activities|nmod|START_ENTITY characterization|dep|activities characterization|nmod|END_ENTITY	Functional characterization of CYP3A4 .16 : catalytic activities toward midazolam and carbamazepine .
20307514	9	midazolam	1526,1535	CYP3A4	1518,1524	midazolam	CYP3A4	MESH:D008874	1576	Chemical	Gene	hydroxylation|nmod:poss|START_ENTITY END_ENTITY|appos|hydroxylation	Significant correlations between carbosulfan activation and CYP marker activities were seen with CYP3A4 -LRB- omeprazole sulfoxidation -RRB- , CYP2C19 -LRB- omeprazole 5-hydroxylation -RRB- and CYP3A4 -LRB- midazolam 1 ' - hydroxylation -RRB- , displaying r -LRB- 2 -RRB- = 0.96 , 0.87 and 0.82 , respectively .
21659627	0	midazolam	54,63	CYP3A4	67,73	midazolam	CYP3A4	MESH:D008874	1576	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY brivanib|nmod|pharmacokinetics effect|nmod|brivanib Lack|nmod|effect Lack|appos|substrate substrate|compound|END_ENTITY	Lack of effect of brivanib on the pharmacokinetics of midazolam , a CYP3A4 substrate , administered intravenously and orally in healthy participants .
21870106	4	midazolam	601,610	CYP3A4	708,714	midazolam	CYP2D6	MESH:D008874	1565	Chemical	Gene	administration|appos|START_ENTITY weeks|nmod|administration used|nsubjpass|weeks used|xcomp|evaluate evaluate|dobj|activities activities|nmod|END_ENTITY	After 2 weeks of berberine -LRB- 300 mg , t.i.d. , p.o. -RRB- administration , midazolam , omeprazole , dextromethorphan , losartan , and caffeine were used to evaluate enzyme activities of CYP3A4 , 2C19 , 2D6 , 2C9 , and CYP1A2 , respectively .
22990330	0	midazolam	48,57	CYP3A4	79,85	midazolam	CYP3A4	MESH:D008874	1576	Chemical	Gene	almorexant|nmod|START_ENTITY interactions|nmod|almorexant interactions|appos|substrates substrates|compound|END_ENTITY	Pharmacokinetic interactions of almorexant with midazolam and simvastatin , two CYP3A4 model substrates , in healthy male subjects .
23327575	0	midazolam	110,119	CYP3A4	0,6	midazolam	CYP3A4	MESH:D008874	1576	Chemical	Gene	measured|nmod|START_ENTITY encodes|advcl|measured encodes|nsubj|SNP SNP|compound|END_ENTITY	CYP3A4 intron 6_C > T SNP -LRB- CYP3A4 * 22 -RRB- encodes lower CYP3A4 activity in cancer patients , as measured with probes midazolam and erythromycin .
23327575	0	midazolam	110,119	CYP3A4	25,31	midazolam	CYP3A4	MESH:D008874	1576	Chemical	Gene	measured|nmod|START_ENTITY encodes|advcl|measured encodes|nsubj|SNP SNP|appos|END_ENTITY	CYP3A4 intron 6_C > T SNP -LRB- CYP3A4 * 22 -RRB- encodes lower CYP3A4 activity in cancer patients , as measured with probes midazolam and erythromycin .
23327575	0	midazolam	110,119	CYP3A4	50,56	midazolam	CYP3A4	MESH:D008874	1576	Chemical	Gene	measured|nmod|START_ENTITY encodes|advcl|measured encodes|dobj|activity activity|compound|END_ENTITY	CYP3A4 intron 6_C > T SNP -LRB- CYP3A4 * 22 -RRB- encodes lower CYP3A4 activity in cancer patients , as measured with probes midazolam and erythromycin .
23381882	0	midazolam	107,116	CYP3A4	118,124	midazolam	CYP3A4	MESH:D008874	1576	Chemical	Gene	using|dobj|START_ENTITY tests|dep|using tests|appos|END_ENTITY	Mechanisms of pharmacokinetic enhancement between ritonavir and saquinavir ; micro/small dosing tests using midazolam -LRB- CYP3A4 -RRB- , fexofenadine -LRB- p-glycoprotein -RRB- , and pravastatin -LRB- OATP1B1 -RRB- as probe drugs .
23674608	0	midazolam	52,61	CYP3A4	77,83	midazolam	CYP3A4	MESH:D008874	1576	Chemical	Gene	START_ENTITY|nmod|markers markers|nmod|END_ENTITY	Comparison of endogenous 4b-hydroxycholesterol with midazolam as markers for CYP3A4 induction by rifampicin .
24895078	0	midazolam	79,88	CYP3A4	52,58	midazolam	CYP3A4	MESH:D008874	1576	Chemical	Gene	drugs|dep|START_ENTITY drugs|nummod|metabolized metabolized|compound|END_ENTITY	Prednisone has no effect on the pharmacokinetics of CYP3A4 metabolized drugs - midazolam and odanacatib .
25287072	0	midazolam	76,85	CYP3A4	4,10	midazolam	CYP3A4	MESH:D008874	1576	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|polymorphism polymorphism|compound|END_ENTITY	The CYP3A4 * 22_C > T single nucleotide polymorphism is associated with reduced midazolam and tacrolimus clearance in stable renal allograft recipients .
16723060	0	midazolam	10,19	ICAM-1	53,59	midazolam	ICAM-1	MESH:D008874	15894(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effect of midazolam on in vitro cerebral endothelial ICAM-1 expression induced by astrocyte-conditioned medium .
23671446	0	midazolam	21,30	MMP-9	34,39	midazolam	MMP-9	MESH:D008874	4318	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|amod|END_ENTITY	Inhibitory effect of midazolam on MMP-9 , MMP-1 and MMP-13 expression in PMA-stimulated human chondrocytes via recovery of NF-kB signaling .
10434822	0	midazolam	98,107	Neuropeptide_Y	0,14	midazolam	Neuropeptide Y	MESH:D008874	4852	Chemical	Gene	effects|nmod|START_ENTITY response|dep|effects response|amod|END_ENTITY	Neuropeptide_Y response to tracheal intubation in anaesthetized children : effects of clonidine vs midazolam as premedication .
19211972	0	midazolam	125,134	c-Fos	35,40	midazolam	c-Fos	MESH:D008874	314322(Tax:10116)	Chemical	Gene	pretreated|nmod|START_ENTITY pretreated|nsubj|Inhibition Inhibition|nmod|expression expression|amod|END_ENTITY	Inhibition of neophobia-stimulated c-Fos expression in the dorsomedial part of the prefrontal cortex in rats pretreated with midazolam .
12814972	0	midazolam	23,32	cyp3a4	142,148	midazolam	cyp3a4	MESH:D008874	1576	Chemical	Gene	metabolism|nmod|START_ENTITY role|nmod|metabolism role|nmod|END_ENTITY	In vitro metabolism of midazolam , triazolam , nifedipine , and testosterone by human liver microsomes and recombinant cytochromes p450 : role of cyp3a4 and cyp3a5 .
11594799	0	midazolam	10,19	interleukin-6	23,36	midazolam	interleukin-6	MESH:D008874	3569	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of midazolam on interleukin-6 mRNA expression in human peripheral blood mononuclear cells in the absence of lipopolysaccharide .
21854184	0	midazolam	15,24	interleukin-6	94,107	midazolam	interleukin-6	MESH:D008874	3569	Chemical	Gene	Combination|nmod|START_ENTITY inhibits|nsubj|Combination inhibits|dobj|production production|amod|END_ENTITY	Combination of midazolam and a cyclooxygenase-2 inhibitor inhibits lipopolysaccharide-induced interleukin-6 production in human peripheral blood mononuclear cells .
23280558	0	midtrimester	24,36	RHD	56,59	midtrimester	RHD	null	6007	Chemical	Gene	genotyping|compound|START_ENTITY genotyping|compound|END_ENTITY	Clinical application of midtrimester non-invasive fetal RHD genotyping and identification of RHD variants in a mixed-ethnic population .
7532053	0	midtrimester	47,59	alpha-fetoprotein	15,32	midtrimester	alpha-fetoprotein	null	174	Chemical	Gene	levels|nmod|START_ENTITY levels|amod|END_ENTITY	Amniotic fluid alpha-fetoprotein levels during midtrimester of trisomy pregnancies .
15297875	0	midzone	82,89	PRC1	48,52	midzone	PRC1	null	9055	Chemical	Gene	formation|compound|START_ENTITY END_ENTITY|nmod|formation	Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation .
22648443	0	mifepristone	10,22	COX-2	26,31	mifepristone	COX-2	MESH:D015735	19225(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of mifepristone on COX-2 both in eutopic and ectopic endometrium in mouse endometriotic model .
10684020	0	mifepristone	12,24	ICE	28,31	mifepristone	ICE	MESH:D015735	834	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	-LSB- Effects of mifepristone on ICE expression and Fas expression in early pregnant chorionic villi -RSB- .
8913436	0	mifepristone	65,77	P-glycoprotein	14,28	mifepristone	P-glycoprotein	MESH:D015735	5243	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activity activity|amod|END_ENTITY	Inhibition of P-glycoprotein activity in human leukemic cells by mifepristone .
16889838	0	mifepristone	21,33	Vpr	92,95	mifepristone	Vpr	MESH:D015735	155807(Tax:11676)	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|END_ENTITY	Antiviral effects of mifepristone on human_immunodeficiency_virus_type-1 _ -LRB- HIV-1 -RRB- : targeting Vpr and its cellular partner , the glucocorticoid receptor -LRB- GR -RRB- .
14593076	0	mifepristone	24,36	androgen_receptor	90,107	mifepristone	androgen receptor	MESH:D015735	367	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Antiandrogen effects of mifepristone on coactivator and corepressor interactions with the androgen_receptor .
15598662	0	mifepristone	87,99	androgen_receptor	166,183	mifepristone	androgen receptor	MESH:D015735	367	Chemical	Gene	START_ENTITY|nmod|N N|acl|revealing revealing|dobj|mechanism mechanism|nmod|antagonists antagonists|compound|END_ENTITY	The androgen_receptor recruits nuclear receptor CoRepressor -LRB- N-CoR -RRB- in the presence of mifepristone via its N and C termini revealing a novel molecular mechanism for androgen_receptor antagonists .
15598662	0	mifepristone	87,99	androgen_receptor	4,21	mifepristone	androgen receptor	MESH:D015735	367	Chemical	Gene	presence|nmod|START_ENTITY CoRepressor|nmod|presence recruits|dobj|CoRepressor recruits|nsubj|END_ENTITY	The androgen_receptor recruits nuclear receptor CoRepressor -LRB- N-CoR -RRB- in the presence of mifepristone via its N and C termini revealing a novel molecular mechanism for androgen_receptor antagonists .
17464718	0	mifepristone	70,82	brain-derived_neurotrophic_factor	11,44	mifepristone	brain-derived neurotrophic factor	MESH:D015735	627	Chemical	Gene	treatment|nmod|START_ENTITY treatment|amod|END_ENTITY	Changes in brain-derived_neurotrophic_factor following treatment with mifepristone in bipolar_disorder and schizophrenia .
24779241	0	mifepristone	17,29	caspase_3	33,42	mifepristone	caspase 3	MESH:D015735	836	Chemical	Gene	influence|nmod|START_ENTITY influence|nmod|expression expression|amod|END_ENTITY	The influence of mifepristone to caspase_3 expression in adenomyosis .
9918590	0	mifepristone	56,68	cytochrome_P-450-3A4	32,52	mifepristone	cytochrome P-450-3A4	MESH:D015735	1576	Chemical	Gene	inactivation|nmod|START_ENTITY inactivation|nmod|END_ENTITY	Mechanism-based inactivation of cytochrome_P-450-3A4 by mifepristone -LRB- RU486 -RRB- .
10682436	0	mifepristone	11,23	epidermal_growth_factor	48,71	mifepristone	epidermal growth factor	MESH:D015735	1950	Chemical	Gene	START_ENTITY|nmod|concentration concentration|nmod|END_ENTITY	-LSB- Effect of mifepristone on the concentration of epidermal_growth_factor in serum and villi of early pregnant women -RSB- .
10682457	0	mifepristone	12,24	epidermal_growth_factor	47,70	mifepristone	epidermal growth factor	MESH:D015735	1950	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of mifepristone on gene expression of epidermal_growth_factor in human uterine_leiomyoma -RSB- .
11783365	0	mifepristone	12,24	estrogen_receptor	42,59	mifepristone	estrogen receptor	MESH:D015735	2099	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of mifepristone on expression of estrogen_receptor and progesterone_receptor in cultured human eutopic and ectopic endometria -RSB- .
15255629	0	mifepristone	61,73	interleukin_1_alpha	113,132	mifepristone	interleukin 1 alpha	MESH:D015735	700193(Tax:9544)	Chemical	Gene	START_ENTITY|nmod|distribution distribution|nmod|END_ENTITY	Effect of early luteal phase administration of a single dose mifepristone on immunohistochemical distribution of interleukin_1_alpha -LRB- IL-1_alpha -RRB- and transforming_growth_factor_beta_1 -LRB- TGF-beta_1 -RRB- in mid-luteal phase ovary of the rhesus_monkey .
9222019	0	mifepristone	31,43	leukaemia_inhibitory_factor	59,86	mifepristone	leukaemia inhibitory factor	MESH:D015735	16878(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	The effect of various doses of mifepristone on endometrial leukaemia_inhibitory_factor expression in the midluteal phase -- an immunohistochemical study .
15774087	0	mifepristone	14,26	nuclear_factor-kappa_B	79,101	mifepristone	nuclear factor-kappa B	MESH:D015735	4790	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	-LSB- Influence of mifepristone and lilopristone on proliferation and expression of nuclear_factor-kappa_B of ectopic stromal cells in vitro -RSB- .
20851233	0	mifepristone	15,27	osteopontin	50,61	mifepristone	osteopontin	MESH:D015735	6696	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expressions expressions|nmod|END_ENTITY	The effects of mifepristone on the expressions of osteopontin , interleukin-6 and leukemia_inhibitory_factor in the villi of early pregnant women .
19339781	0	mifepristone	43,55	progesterone_receptor_a	59,82	mifepristone	progesterone receptor a	MESH:D015735	6277	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effects of progesterone and its antagonist mifepristone on progesterone_receptor_a expression in human umbilical vein endothelial cells .
18832805	0	mifepristone	61,73	prolactin	30,39	mifepristone	prolactin	MESH:D015735	24683(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY secretion|acl|induced secretion|compound|END_ENTITY	Pituitary changes involved in prolactin secretion induced by mifepristone and naloxone during late pregnancy .
11778540	0	mifepristone	11,23	tumor_necrosis_factor-alpha	45,72	mifepristone	tumor necrosis factor-alpha	MESH:D015735	7124	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of mifepristone on the expression of tumor_necrosis_factor-alpha and transforming_growth_factor-beta in decidua of early pregnancy -RSB- .
21845063	0	miglitol	11,19	adiponectin	55,66	miglitol	adiponectin	MESH:C045621	9370	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of miglitol in platelet-derived microparticle , adiponectin , and selectin level in patients with type_2_diabetes_mellitus .
19027977	0	miglitol	53,61	cystatin_C	71,81	miglitol	cystatin C	MESH:C045621	1471	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|level level|amod|END_ENTITY	Effect of insulin-unstimulated diabetic therapy with miglitol on serum cystatin_C level and its clinical significance .
12190996	0	miglitol	15,23	glucagon-like_peptide-1	27,50	miglitol	glucagon-like peptide-1	MESH:C045621	2641	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|secretion secretion|amod|END_ENTITY	The effects of miglitol on glucagon-like_peptide-1 secretion and appetite sensations in obese_type_2 diabetics .
20519807	0	miglitol	55,63	glucagon-like_peptide-1	74,97	miglitol	glucagon-like peptide-1	MESH:C045621	2641	Chemical	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Effects of pre-meal versus post-meal administration of miglitol on plasma glucagon-like_peptide-1 and glucosedependent insulinotropic polypeptide levels in healthy men .
21126213	0	miglitol	99,107	glucagon-like_peptide-1	175,198	miglitol	glucagon-like peptide-1	MESH:C045621	2641	Chemical	Gene	availability|nmod|START_ENTITY increasing|dobj|availability leads|dep|increasing leads|nsubj|levels levels|amod|END_ENTITY	Targeting enteral endocrinal L-cells with dietary carbohydrates , by increasing the availability of miglitol in the intestinal lumen , leads to multi-fold enhancement of plasma glucagon-like_peptide-1 levels in non-diabetic canines .
24843527	0	miglitol	11,19	insulin	82,89	miglitol	insulin	MESH:C045621	3630	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|compound|END_ENTITY	Effects of miglitol taken just before or after breakfast on plasma glucose , serum insulin , glucagon and incretin levels after lunch in men with normal glucose tolerance , impaired fasting glucose or impaired_glucose_tolerance .
17624027	0	miglustat	88,97	glucosylceramide_synthase	52,77	miglustat	glucosylceramide synthase	MESH:C059896	83626(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|pharmacokinetics pharmacokinetics|nmod|inhibitor inhibitor|amod|END_ENTITY	The pharmacokinetics and tissue distribution of the glucosylceramide_synthase inhibitor miglustat in the rat .
17720777	0	miglustat	52,61	glucosylceramide_synthase	79,104	miglustat	glucosylceramide synthase	MESH:C059896	7357	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Influence of food intake on the pharmacokinetics of miglustat , an inhibitor of glucosylceramide_synthase .
2769256	0	milacemide	34,44	monoamine_oxidase_B	95,114	milacemide	monoamine oxidase B	MESH:C039332	4129	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	The novel neuropsychotropic agent milacemide is a specific enzyme-activated inhibitor of brain monoamine_oxidase_B .
3346666	0	milacemide	66,76	monoamine_oxidase_B	98,117	milacemide	monoamine oxidase B	MESH:C039332	4129	Chemical	Gene	glycine|nmod|START_ENTITY Formation|nmod|glycine mediated|nsubjpass|Formation mediated|nmod|END_ENTITY	Formation of the neurotransmitter glycine from the anticonvulsant milacemide is mediated by brain monoamine_oxidase_B .
19912061	0	mildronate	45,55	carnitine_acetyltransferase	14,41	mildronate	carnitine acetyltransferase	MESH:C050147	1384	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of carnitine_acetyltransferase by mildronate , a regulator of energy metabolism .
15337646	0	milnacipran	41,52	norepinephrine_transporter	56,82	milnacipran	norepinephrine transporter	MESH:C048107	6530	Chemical	Gene	START_ENTITY|nmod|polymorphisms polymorphisms|compound|END_ENTITY	Prediction of antidepressant response to milnacipran by norepinephrine_transporter gene polymorphisms .
14533141	0	milnacipran	42,53	prolactin	76,85	milnacipran	prolactin	MESH:C048107	5617	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of pindolol and milnacipran versus milnacipran and placebo on plasma prolactin and adrenocorticotrophic hormone in depressed subjects .
24421316	0	mimosine	55,63	ATM	137,140	mimosine	ATM	MESH:D008898	472	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Activation of the prereplication complex is blocked by mimosine through reactive oxygen species-activated ataxia_telangiectasia_mutated -LRB- ATM -RRB- protein without DNA damage .
22047208	0	mimosine_tetrapeptides	25,47	neuraminidase	83,96	mimosine tetrapeptides	neuraminidase	null	4758	Chemical	Gene	synthesis|nmod|START_ENTITY synthesis|nmod|END_ENTITY	Solid-phase synthesis of mimosine_tetrapeptides and their inhibitory activities on neuraminidase and tyrosinase .
2957818	0	minactivin	109,119	PAI-2	92,97	minactivin	PAI-2	MESH:C039812	5055	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	The resistance of fibrin-stimulated tissue plasminogen activator to inactivation by a class PAI-2 inhibitor -LRB- minactivin -RRB- .
2896781	0	minaprine	11,20	prolactin	49,58	minaprine	prolactin	MESH:C006149	24683(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of minaprine , a novel antidepressant , on prolactin secretion in the rat .
10493866	0	minichaperone	50,63	GroEL	44,49	minichaperone	GroEL	null	3329	Chemical	Gene	START_ENTITY|nsubj|Identification Identification|nmod|site site|nmod|END_ENTITY	Identification of substrate binding site of GroEL minichaperone in solution .
15638807	0	minichaperone	14,27	interferon_gamma	102,118	minichaperone	interferon gamma	null	3458	Chemical	Gene	Production|nmod|START_ENTITY Production|nmod|END_ENTITY	Production of minichaperone -LRB- sht GroEL191-345 -RRB- and its function in the refolding of recombinant human interferon_gamma .
20868701	0	minocycline	11,22	5-lipoxygenase	90,104	minocycline	5-lipoxygenase	MESH:D008911	11689(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|receptors receptors|nmod|mice mice|amod|END_ENTITY	Effects of minocycline on cocaine sensitization and phosphorylation of GluR1 receptors in 5-lipoxygenase deficient mice .
21184825	0	minocycline	30,41	Bcl-2	95,100	minocycline	Bcl-2	MESH:D008911	24224(Tax:10116)	Chemical	Gene	mechanisms|nmod|START_ENTITY mechanisms|dep|Roles Roles|nmod|END_ENTITY	Neuroprotective mechanisms of minocycline against sphingomyelinase/ceramide _ toxicity : Roles of Bcl-2 and thioredoxin .
23554704	0	minocycline	11,22	NGF	44,47	minocycline	NGF	MESH:D008911	310738(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effects of minocycline on the expression of NGF and HSP70 and its neuroprotection role following intracerebral_hemorrhage in rats .
17942809	0	minocycline	37,48	annexin_V	77,86	minocycline	annexin V	MESH:D008911	11747(Tax:10090)	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|END_ENTITY	Monitoring the protective effects of minocycline treatment with radiolabeled annexin_V in an experimental model of focal cerebral_ischemia .
22553633	0	minocycline	11,22	bax	47,50	minocycline	bax	MESH:D008911	24887(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of minocycline on expression of bcl-2 , bax in early retinal_neuropathy of diabetes in rats .
22553633	0	minocycline	11,22	bcl-2	40,45	minocycline	bcl-2	MESH:D008911	24224(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effects of minocycline on expression of bcl-2 , bax in early retinal_neuropathy of diabetes in rats .
3876326	0	minocycline	67,78	beta-lactamase	14,28	minocycline	beta-lactamase	MESH:D008911	13913583	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|synthesis synthesis|amod|END_ENTITY	Inhibition of beta-lactamase synthesis in Staphylococcus_aureus by minocycline .
16712806	0	minocycline	22,33	dopamine_transporters	54,75	minocycline	dopamine transporters	MESH:D008911	6531	Chemical	Gene	START_ENTITY|nmod|reduction reduction|nmod|END_ENTITY	Protective effects of minocycline on the reduction of dopamine_transporters in the striatum after administration of methamphetamine : a positron emission tomography study in conscious monkeys .
21669931	0	minocycline	98,109	matrix_metalloproteinase	143,167	minocycline	matrix metalloproteinase	MESH:D008911	35997(Tax:7227)	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|END_ENTITY	Neural circuit architecture_defects in a Drosophila model of Fragile_X_syndrome are alleviated by minocycline treatment and genetic removal of matrix_metalloproteinase .
16846501	0	minocycline	8,19	matrix_metalloproteinases_2_and_9	48,81	minocycline	matrix metalloproteinases 2 and 9	MESH:D008911	81686(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Delayed minocycline inhibits ischemia-activated matrix_metalloproteinases_2_and_9 after experimental stroke .
17874104	0	minodronate	50,61	p38_mitogen_activated_protein_kinase	85,121	minodronate	p38 mitogen activated protein kinase	MESH:C087958	1432	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|amod|END_ENTITY	Efficacy of a nitrogen-containing bisphosphonate , minodronate , in conjunction with a p38_mitogen_activated_protein_kinase inhibitor or doxorubicin against malignant_bone_tumor cells .
7625861	0	minoxidil	37,46	elastin	15,22	minoxidil	elastin	MESH:D008914	396441(Tax:9031)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Stimulation of elastin expression by minoxidil in chick skin fibroblasts .
22509825	0	mirabegron	93,103	b3-adrenoceptor	128,143	mirabegron	b3-adrenoceptor	MESH:C520025	155	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Identification of human cytochrome_P450 isoforms and esterases involved in the metabolism of mirabegron , a potent and selective b3-adrenoceptor agonist .
22834478	0	mirabegron	70,80	b3-adrenoceptor	105,120	mirabegron	b3-adrenoceptor	MESH:C520025	155	Chemical	Gene	enzymes|nmod|START_ENTITY inhibition|nmod|enzymes agonist|nmod|inhibition agonist|nsubj|END_ENTITY	In vitro inhibition and induction of human cytochrome_P450 enzymes by mirabegron , a potent and selective b3-adrenoceptor agonist .
23063375	0	mirabegron	30,40	b3-adrenoceptor	44,59	mirabegron	b3-adrenoceptor	MESH:C520025	155	Chemical	Gene	properties|nmod|START_ENTITY properties|appos|agonist agonist|amod|END_ENTITY	Pharmacokinetic properties of mirabegron , a b3-adrenoceptor agonist : results from two phase I , randomized , multiple-dose studies in healthy young and elderly men and women .
23625188	0	mirabegron	75,85	b3-adrenoceptor	89,104	mirabegron	b3-adrenoceptor	MESH:C520025	155	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Role of cytochrome p450 isoenzymes 3A and 2D6 in the in vivo metabolism of mirabegron , a b3-adrenoceptor agonist .
23728524	0	mirabegron	14,24	b3-adrenoceptor	49,64	mirabegron	b3-adrenoceptor	MESH:C520025	155	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|agonist agonist|amod|END_ENTITY	The effect of mirabegron , a potent and selective b3-adrenoceptor agonist , on the pharmacokinetics of CYP2D6 substrates desipramine and metoprolol .
23850394	0	mirabegron	71,81	b3-adrenoceptor	47,62	mirabegron	b3-adrenoceptor	MESH:C520025	155	Chemical	Gene	START_ENTITY|nsubj|Evidence Evidence|amod|available available|nmod|use use|nmod|agonist agonist|amod|END_ENTITY	Evidence available on the use of the selective b3-adrenoceptor agonist mirabegron for the treatment of overactive_bladder .
24178236	0	mirabegron	20,30	b3-adrenoceptor	34,49	mirabegron	b3-adrenoceptor	MESH:C520025	155	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Pharmacokinetics of mirabegron , a b3-adrenoceptor agonist for treatment of overactive_bladder , in healthy Japanese male subjects : results from single - and multiple-dose studies .
24458878	0	mirabegron	48,58	b3-adrenoceptor	23,38	mirabegron	b3-adrenoceptor	MESH:C520025	155	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Onset of action of the b3-adrenoceptor agonist , mirabegron , in Phase II and III clinical trials in patients with overactive_bladder .
25092537	0	mirabegron	40,50	b3-adrenoceptor	16,31	mirabegron	b3-adrenoceptor	MESH:C520025	155	Chemical	Gene	START_ENTITY|nsubj|Efficacy Efficacy|nmod|agonist agonist|amod|END_ENTITY	Efficacy of the b3-adrenoceptor agonist mirabegron for the treatment of overactive_bladder by severity of incontinence at baseline : a post hoc analysis of pooled data from three randomised phase 3 trials .
17192957	0	mirtazapine	65,76	MAOA	4,8	mirtazapine	MAOA	MESH:C035133	4128	Chemical	Gene	polymorphism|nmod|START_ENTITY polymorphism|compound|END_ENTITY	The MAOA T941G polymorphism and short-term treatment response to mirtazapine and paroxetine in major_depression .
10451911	0	mirtazapine	11,22	prolactin	42,51	mirtazapine	prolactin	MESH:C035133	5617	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of mirtazapine on growth_hormone , prolactin , and cortisol secretion in healthy male subjects .
15829422	0	mirtazapine	10,21	serotonin_transporter	35,56	mirtazapine	serotonin transporter	MESH:C035133	6532	Chemical	Gene	treatment|amod|START_ENTITY Effect|nmod|treatment Effect|nmod|END_ENTITY	Effect of mirtazapine treatment on serotonin_transporter in blood peripheral lymphocytes of major_depression patients .
16391422	0	mirtazepine	24,35	brain-derived_neurotrophic_factor	44,77	mirtazepine	brain-derived neurotrophic factor	null	24225(Tax:10116)	Chemical	Gene	treatment|nmod|START_ENTITY induces|nsubj|treatment induces|dobj|expression expression|amod|END_ENTITY	Repeated treatment with mirtazepine induces brain-derived_neurotrophic_factor gene expression in rats .
7800581	0	misoprostol	11,22	C-peptide	79,88	misoprostol	C-peptide	MESH:D016595	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|nmod|END_ENTITY	-LSB- Effect of misoprostol , a synthetic prostaglandin_E analog , on levels of serum C-peptide in serum and glucose tolerance -RSB- .
26718808	0	misoprostol	68,79	Oxytocin	0,8	misoprostol	Oxytocin	MESH:D016595	5020	Chemical	Gene	Uniject|nmod|START_ENTITY END_ENTITY|nmod|Uniject	Oxytocin via Uniject -LRB- a prefilled single-use injection -RRB- versus oral misoprostol for prevention of postpartum_haemorrhage at the community level : a cluster-randomised controlled trial .
16097971	0	misoprostol	13,24	adrenomedullin	69,83	misoprostol	adrenomedullin	MESH:D016595	133	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|levels levels|compound|END_ENTITY	Influence of misoprostol -LRB- PGE1 -RRB- on amniotic_fluid and maternal serum adrenomedullin levels .
10563531	0	misoprostol	10,21	beta2-microglobulin	31,50	misoprostol	beta2-microglobulin	MESH:D016595	567	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of misoprostol on serum beta2-microglobulin in the course of viral_hepatitis_B .
3080282	0	misoprostol	10,21	gastrin	60,67	misoprostol	gastrin	MESH:D016595	2520	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of misoprostol , an antiulcer prostaglandin , on serum gastrin in patients with duodenal_ulcer .
12202418	0	misoprostol	93,104	hCG	22,25	misoprostol	hCG	MESH:D016595	3342	Chemical	Gene	administration|nmod|START_ENTITY END_ENTITY|nmod|administration	The kinetics of serum hCG and progesterone in response to oral and vaginal administration of misoprostol during medical termination of early pregnancy .
19757270	0	misoprostol	25,36	oxytocin	56,64	misoprostol	oxytocin	MESH:D016595	5020	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of sublingual misoprostol versus intravenous oxytocin in reducing bleeding after caesarean section .
20347088	0	misoprostol	32,43	oxytocin	65,73	misoprostol	oxytocin	MESH:D016595	5020	Chemical	Gene	oxytocin|compound|START_ENTITY oxytocin|nmod|END_ENTITY	Induction of labor with vaginal misoprostol plus oxytocin versus oxytocin alone .
9699753	0	misoprostol	22,33	oxytocin	93,101	misoprostol	oxytocin	MESH:D016595	5020	Chemical	Gene	START_ENTITY|nmod|treatment treatment|nmod|postpartum_hemorrhage postpartum_hemorrhage|amod|unresponsive unresponsive|nmod|END_ENTITY	Rectally administered misoprostol for the treatment of postpartum_hemorrhage unresponsive to oxytocin and ergometrine : a descriptive study .
1535193	0	mithramycin	46,57	c-myc	23,28	mithramycin	c-myc	MESH:D008926	4609	Chemical	Gene	transcription|nmod|START_ENTITY transcription|amod|END_ENTITY	In vitro inhibition of c-myc transcription by mithramycin .
2966584	0	mithramycin	85,96	c-myc	24,29	mithramycin	c-myc	MESH:D008926	4609	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|expression expression|amod|END_ENTITY	Selective inhibition of c-myc expression by the ribonucleic acid synthesis inhibitor mithramycin .
12846580	0	mithramycin	37,48	c-src	14,19	mithramycin	c-src	MESH:D008926	6714	Chemical	Gene	transcription|nmod|START_ENTITY transcription|amod|END_ENTITY	Inhibition of c-src transcription by mithramycin : structure-activity relationships of biosynthetically produced mithramycin analogues using the c-src promoter as target .
20331637	0	mithramycin	9,20	p53	58,61	mithramycin	p53	MESH:D008926	7157	Chemical	Gene	exerts|nsubj|START_ENTITY exerts|dobj|effect effect|nmod|END_ENTITY	Low-dose mithramycin exerts its anticancer effect via the p53 signaling pathway and synergizes with nutlin-3 in gynecologic_cancers .
23797928	0	mitiglinide	11,22	insulin	39,46	mitiglinide	insulin	MESH:C087255	3630	Chemical	Gene	START_ENTITY|appos|secretagogue secretagogue|compound|END_ENTITY	Effects of mitiglinide , a short-acting insulin secretagogue , on daily glycemic variability and oxidative stress markers in Japanese patients with type_2_diabetes_mellitus .
3495334	0	mitomycin	101,110	interleukin-2	34,47	mitomycin	interleukin-2	MESH:D016685	16183(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Synergistic effect of recombinant interleukin-2 on the inhibition of growth of adenocarcinoma 755 by mitomycin .
11275687	0	mitomycin_C	45,56	CFTR	26,30	mitomycin C	CFTR	MESH:D016685	1080	Chemical	Gene	enhancement|nmod|START_ENTITY enhancement|nmod|expression expression|amod|END_ENTITY	Functional enhancement of CFTR expression by mitomycin_C .
10376975	0	mitomycin_C	25,36	DT-diaphorase	76,89	mitomycin C	DT-diaphorase	MESH:D016685	1728	Chemical	Gene	cytotoxicity|nmod|START_ENTITY cytotoxicity|nmod|inducers inducers|nmod|END_ENTITY	Enhanced cytotoxicity of mitomycin_C in human tumour cells with inducers of DT-diaphorase .
11103802	0	mitomycin_C	30,41	DT-diaphorase	58,71	mitomycin C	DT-diaphorase	MESH:D016685	1728	Chemical	Gene	responses|nmod|START_ENTITY responses|nmod|basis basis|nmod|activity activity|amod|END_ENTITY	Predicting tumor responses to mitomycin_C on the basis of DT-diaphorase activity or drug metabolism by tumor homogenates : implications for enzyme-directed bioreductive drug development .
11350900	0	mitomycin_C	74,85	DT-diaphorase	14,27	mitomycin C	DT-diaphorase	MESH:D016685	1728	Chemical	Gene	activity|amod|START_ENTITY correlates|nmod|activity correlates|nsubj|Expression Expression|nmod|reductase reductase|amod|END_ENTITY	Expression of DT-diaphorase and cytochrome P450 reductase correlates with mitomycin_C activity in human bladder_tumors .
1324793	0	mitomycin_C	155,166	DT-diaphorase	9,22	mitomycin C	DT-diaphorase	MESH:D016685	1728	Chemical	Gene	xenografts|nmod|START_ENTITY response|nmod|xenografts relationship|nmod|response activity|dep|relationship activity|compound|END_ENTITY	Elevated DT-diaphorase activity and messenger RNA content in human non-small_cell_lung_carcinoma : relationship to the response of lung_tumor xenografts to mitomycin_C .
1373799	0	mitomycin_C	83,94	DT-diaphorase	51,64	mitomycin C	DT-diaphorase	MESH:D016685	18104(Tax:10090)	Chemical	Gene	oxidoreductase|nmod|START_ENTITY oxidoreductase|appos|END_ENTITY	Role of NAD -LRB- P -RRB- H : -LRB- quinone acceptor -RRB- oxidoreductase -LRB- DT-diaphorase -RRB- in activation of mitomycin_C under hypoxia .
1510975	0	mitomycin_C	27,38	DT-diaphorase	42,55	mitomycin C	DT-diaphorase	MESH:D016685	24314(Tax:10116)	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Bioreductive activation of mitomycin_C by DT-diaphorase .
7488245	0	mitomycin_C	71,82	DT-diaphorase	13,26	mitomycin C	DT-diaphorase	MESH:D016685	18104(Tax:10090)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of DT-diaphorase by doxorubicin and combination therapy with mitomycin_C in vitro .
8264549	0	mitomycin_C	46,57	DT-diaphorase	29,42	mitomycin C	DT-diaphorase	MESH:D016685	1728	Chemical	Gene	inactivation|nmod|START_ENTITY inactivation|nmod|END_ENTITY	pH-dependent inactivation of DT-diaphorase by mitomycin_C and porfiromycin .
8473041	0	mitomycin_C	39,50	DT-diaphorase	13,26	mitomycin C	DT-diaphorase	MESH:D016685	1728	Chemical	Gene	efficacy|amod|START_ENTITY activity|nmod|efficacy activity|amod|END_ENTITY	Relevance of DT-diaphorase activity to mitomycin_C -LRB- MMC -RRB- efficacy on human cancer cells : differences in in vitro and in vivo systems .
8504072	0	mitomycin_C	59,70	DT-diaphorase	90,103	mitomycin C	DT-diaphorase	MESH:D016685	1728	Chemical	Gene	induced|nmod|START_ENTITY induced|nmod|END_ENTITY	Sequence-selective alkylation and cross-linking induced by mitomycin_C upon activation by DT-diaphorase .
8567314	0	mitomycin_C	63,74	DT-diaphorase	0,13	mitomycin C	DT-diaphorase	MESH:D016685	1728	Chemical	Gene	modulation|nmod|START_ENTITY enzyme|nmod|modulation enzyme|nsubj|END_ENTITY	DT-diaphorase as a target enzyme for biochemical modulation of mitomycin_C .
8620484	0	mitomycin_C	151,162	DT-diaphorase	52,65	mitomycin C	DT-diaphorase	MESH:D016685	1728	Chemical	Gene	treatment|amod|START_ENTITY splicing|nmod|treatment splicing|nmod|transcripts transcripts|amod|END_ENTITY	Alternative splicing and differential expression of DT-diaphorase transcripts in human colon_tumors and in peripheral mononuclear cells in response to mitomycin_C treatment .
8665520	0	mitomycin_C	58,69	DT-diaphorase	0,13	mitomycin C	DT-diaphorase	MESH:D016685	1728	Chemical	Gene	lines|amod|START_ENTITY END_ENTITY|nmod|lines	DT-diaphorase as a critical determinant of sensitivity to mitomycin_C in human colon_and_gastric_carcinoma cell lines .
8678904	0	mitomycin_C	59,70	DT-diaphorase	10,23	mitomycin C	DT-diaphorase	MESH:D016685	1728	Chemical	Gene	lines|amod|START_ENTITY Increased|nmod|lines Increased|dobj|expression expression|amod|END_ENTITY	Increased DT-diaphorase expression and cross-resistance to mitomycin_C in a series of cisplatin-resistant human ovarian_cancer cell lines .
9058597	0	mitomycin_C	141,152	DT-diaphorase	105,118	mitomycin C	DT-diaphorase	MESH:D016685	1728	Chemical	Gene	treatment|amod|START_ENTITY induced|nmod|treatment induced|nsubj|Involvement Involvement|nmod|factors factors|nmod|control control|nmod|expression expression|amod|END_ENTITY	Involvement of activator_protein-1 and nuclear_factor-kappaB transcription factors in the control of the DT-diaphorase expression induced by mitomycin_C treatment .
9878310	0	mitomycin_C	35,46	DT-diaphorase	18,31	mitomycin C	DT-diaphorase	MESH:D016685	1728	Chemical	Gene	resistance|amod|START_ENTITY importance|nmod|resistance importance|nmod|END_ENTITY	The importance of DT-diaphorase in mitomycin_C resistance in human colon_cancer cell lines .
19959635	0	mitomycin_C	10,21	IL-1R	25,30	mitomycin C	IL-1R	MESH:D016685	3554	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of mitomycin_C on IL-1R expression , IL-1-related hepatocyte_growth_factor secretion and corneal epithelial cell migration .
8569432	0	mitomycin_C	30,41	MX-1	92,96	mitomycin C	MX-1	MESH:D016685	4599	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Dietary menhaden oil enhances mitomycin_C antitumor activity toward human mammary_carcinoma MX-1 .
10757444	0	mitomycin_C	11,22	P-glycoprotein	87,101	mitomycin C	P-glycoprotein	MESH:D016685	5243	Chemical	Gene	pretreatment|amod|START_ENTITY pretreatment|nmod|multidrug multidrug|dobj|expression expression|amod|END_ENTITY	Effects of mitomycin_C and carboplatin pretreatment on multidrug resistance-associated P-glycoprotein expression and on subsequent suppression of tumor growth by doxorubicin and paclitaxel in human metastatic breast_cancer xenografted nude_mice .
11311122	0	mitomycin_C	24,35	P-glycoprotein	55,69	mitomycin C	P-glycoprotein	MESH:D016685	5243	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|amod|END_ENTITY	Differential effects of mitomycin_C and doxorubicin on P-glycoprotein expression .
16242241	0	mitomycin_C	33,44	SOD1	14,18	mitomycin C	SOD1	MESH:D016685	6647	Chemical	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Inhibition of SOD1 expression by mitomycin_C is a non-specific consequence of cellular toxicity .
15947684	0	mitomycin_C	125,136	Vascular_endothelial_growth_factor	0,34	mitomycin C	Vascular endothelial growth factor	MESH:D016685	7422	Chemical	Gene	cytotoxicity|nmod|START_ENTITY enhances|dobj|cytotoxicity enhances|nsubj|pretreatment pretreatment|amod|END_ENTITY	Vascular_endothelial_growth_factor antisense pretreatment of bladder_cancer cells significantly enhances the cytotoxicity of mitomycin_C , gemcitabine and Cisplatin .
17633202	0	mitomycin_C	67,78	constitutive_androstane_receptor	11,43	mitomycin C	constitutive androstane receptor	MESH:D016685	9970	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of constitutive_androstane_receptor on the cytotoxicity of mitomycin_C and 5 - -LRB- aziridin-1-yl -RRB- -3 - hydroxymethyl-1-methylindole-4 ,7 - dione -RSB- .
21567106	0	mitomycin_C	93,104	growth_hormone	16,30	mitomycin C	growth hormone	MESH:D016685	2688	Chemical	Gene	reduces|nmod|START_ENTITY reduces|nsubj|END_ENTITY	Autocrine human growth_hormone reduces mammary and endometrial_carcinoma cell sensitivity to mitomycin_C .
2113592	0	mitomycin_C	60,71	interleukin_2	26,39	mitomycin C	interleukin 2	MESH:D016685	3558	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of recombinant interleukin_2 in combination with mitomycin_C on advanced cancer .
24505408	0	mitomycin_C	117,128	p-glycoprotein	28,42	mitomycin C	p-glycoprotein	MESH:D016685	5243	Chemical	Gene	demonstrated|nmod|START_ENTITY demonstrated|nsubj|trafficking trafficking|nmod|cells cells|amod|END_ENTITY	Drug-induced trafficking of p-glycoprotein in human brain capillary endothelial cells as demonstrated by exposure to mitomycin_C .
9736481	0	mitomycin_C	64,75	phosphoenolpyruvate_carboxykinase	79,112	mitomycin C	phosphoenolpyruvate carboxykinase	MESH:D016685	396458(Tax:9031)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Developmentally specific effects of the DNA cross-linking agent mitomycin_C on phosphoenolpyruvate_carboxykinase gene expression in vivo : correlation with changes in chromatin structure within the promoter region of the gene .
9143892	0	mitomycin_C	11,22	proliferating_cell_nuclear_antigen	44,78	mitomycin C	proliferating cell nuclear antigen	MESH:D016685	100339381(Tax:9986)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of mitomycin_C on the expression of proliferating_cell_nuclear_antigen after filtering surgery in rabbits .
20735383	0	mitomycin_C	10,21	vascular_endothelial_growth_factor	43,77	mitomycin C	vascular endothelial growth factor	MESH:D016685	83785(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|concentrations concentrations|nmod|END_ENTITY	Effect of mitomycin_C on concentrations of vascular_endothelial_growth_factor and its receptors in bladder_cancer cells and in bladders of rats intravesically instilled with mitomycin_C .
20735383	0	mitomycin_C	174,185	vascular_endothelial_growth_factor	43,77	mitomycin C	vascular endothelial growth factor	MESH:D016685	83785(Tax:10116)	Chemical	Gene	instilled|nmod|START_ENTITY instilled|nsubj|Effect Effect|nmod|mitomycin_C mitomycin_C|nmod|concentrations concentrations|nmod|END_ENTITY	Effect of mitomycin_C on concentrations of vascular_endothelial_growth_factor and its receptors in bladder_cancer cells and in bladders of rats intravesically instilled with mitomycin_C .
1911046	0	mitomycin_C	86,97	xanthine_oxidase	8,24	mitomycin C	xanthine oxidase	MESH:D016685	22436(Tax:10090)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of xanthine_oxidase in the potentiation of doxorubicin-induced cardiotoxicity by mitomycin_C .
12015757	0	mitotane	197,205	P-glycoprotein	211,225	mitotane	P-glycoprotein	MESH:D008939	5243	Chemical	Gene	START_ENTITY|nmod|antagonist antagonist|amod|END_ENTITY	A phase II trial of combination chemotherapy and surgical resection for the treatment of metastatic adrenocortical_carcinoma : continuous infusion doxorubicin , vincristine , and etoposide with daily mitotane as a P-glycoprotein antagonist .
19340456	0	mitoxantone	60,71	ABCG2	0,5	mitoxantone	ABCG2	null	9429	Chemical	Gene	related|nmod|START_ENTITY related|nsubjpass|END_ENTITY	ABCG2 is related with the grade of glioma and resistance to mitoxantone , a chemotherapeutic drug for glioma .
11406094	0	mitoxantrone	40,52	ABCG2	78,83	mitoxantrone	ABCG2	MESH:D008942	9429	Chemical	Gene	protein|amod|START_ENTITY protein|appos|MXR MXR|appos|END_ENTITY	A functional assay for detection of the mitoxantrone resistance protein , MXR -LRB- ABCG2 -RRB- .
16960658	0	mitoxantrone	79,91	ABCG2	112,117	mitoxantrone	ABCG2	MESH:D008942	9429	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Modulation of function of three ABC drug transporters , P-glycoprotein -LRB- ABCB1 -RRB- , mitoxantrone resistance protein -LRB- ABCG2 -RRB- and multidrug resistance protein 1 -LRB- ABCC1 -RRB- by tetrahydrocurcumin , a major metabolite of curcumin .
23592396	0	mitoxantrone	33,45	Abcg2	56,61	mitoxantrone	Abcg2	MESH:D008942	312382(Tax:10116)	Chemical	Gene	increases|amod|START_ENTITY induction|nmod|increases expression|amod|induction expression|amod|END_ENTITY	Estrogen receptor a induction by mitoxantrone increases Abcg2 expression in placental trophoblast cells .
19632767	0	mitoxantrone	74,86	B-type_natriuretic_peptide	0,26	mitoxantrone	B-type natriuretic peptide	MESH:D008942	4879	Chemical	Gene	therapy|amod|START_ENTITY END_ENTITY|nmod|therapy	B-type_natriuretic_peptide as a marker of subclinical heart_injury during mitoxantrone therapy in MS patients -- preliminary study .
8477064	0	mitoxantrone	41,53	CHOP	23,27	mitoxantrone	CHOP	MESH:D008942	1649	Chemical	Gene	therapy|appos|START_ENTITY therapy|compound|END_ENTITY	A comparative study of CHOP versus MEVP -LRB- mitoxantrone , etoposide , vindesine , prednisolone -RRB- therapy for intermediate-grade and high-grade non-Hodgkin 's _ lymphoma : a prospective randomized study .
11529467	0	mitoxantrone	46,58	CPT-11	37,43	mitoxantrone	CPT-11	MESH:D008942	963084(Tax:115711)	Chemical	Gene	irinotecan|amod|START_ENTITY irinotecan|appos|END_ENTITY	Combination therapy with irinotecan -LRB- CPT-11 -RRB- , mitoxantrone , and dexamethasone in relapsed or refractory_non-Hodgkin 's _ lymphoma : a pilot study .
8157471	0	mitoxantrone	17,29	GM-CSF	84,90	mitoxantrone	GM-CSF	MESH:D008942	1437	Chemical	Gene	trial|nmod|START_ENTITY trial|appos|END_ENTITY	Phase I trial of mitoxantrone and granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- in patients with advanced solid malignancies .
22952942	0	mitoxantrone	55,67	JNK	90,93	mitoxantrone	JNK	MESH:D008942	5599	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Gene silencing of FANCF potentiates the sensitivity to mitoxantrone through activation of JNK and p38 signal pathways in breast_cancer cells .
11406094	0	mitoxantrone	40,52	MXR	73,76	mitoxantrone	MXR	MESH:D008942	9429	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	A functional assay for detection of the mitoxantrone resistance protein , MXR -LRB- ABCG2 -RRB- .
16434618	0	mitoxantrone	68,80	Multidrug_resistance_protein_1	0,30	mitoxantrone	Multidrug resistance protein 1	MESH:D008942	4363	Chemical	Gene	mediates|advcl|START_ENTITY mediates|nsubj|END_ENTITY	Multidrug_resistance_protein_1 -LRB- MRP1 , ABCC1 -RRB- mediates resistance to mitoxantrone via glutathione-dependent drug efflux .
10751862	0	mitoxantrone	38,50	Prostate_specific_antigen	0,25	mitoxantrone	Prostate specific antigen	MESH:D008942	354	Chemical	Gene	response|acl|START_ENTITY response|amod|END_ENTITY	Prostate_specific_antigen response to mitoxantrone and prednisone in patients with refractory_prostate_cancer : prognostic factors and generalizability of a multicenter trial to clinical practice .
23856547	0	mitoxantrone	81,93	T-cell_protein_tyrosine_phosphatase	23,58	mitoxantrone	T-cell protein tyrosine phosphatase	MESH:D008942	5771	Chemical	Gene	activation|nmod|START_ENTITY activation|nsubj|mechanism mechanism|nmod|END_ENTITY	Molecular mechanism of T-cell_protein_tyrosine_phosphatase -LRB- TCPTP -RRB- activation by mitoxantrone .
9162224	0	mitoxantrone	58,70	Tumour_necrosis_factor	0,22	mitoxantrone	Tumour necrosis factor	MESH:D008942	7124	Chemical	Gene	effect|nmod|START_ENTITY enhances|dobj|effect enhances|nsubj|END_ENTITY	Tumour_necrosis_factor enhances the therapeutic effect of mitoxantrone in human ovarian_cancer xenograft .
10360370	0	mitoxantrone	55,67	VP-16	83,88	mitoxantrone	VP-16	MESH:D008942	3054	Chemical	Gene	START_ENTITY|acl|combined combined|nmod|END_ENTITY	Multicenter randomized phase II trial of idarubicin vs mitoxantrone , combined with VP-16 and cytarabine for induction/consolidation therapy , followed by a feasibility study of autologous peripheral blood stem cell transplantation in elderly patients with acute_myeloid_leukemia .
18365871	0	mitoxantrone	44,56	epidermal_growth_factor_receptor	128,160	mitoxantrone	epidermal growth factor receptor	MESH:D008942	1956	Chemical	Gene	induced|nmod|START_ENTITY induced|nmod|END_ENTITY	Improvement of cytotoxic effects induced by mitoxantrone on hormone-refractory metastatic prostate_cancer cells by co-targeting epidermal_growth_factor_receptor and hedgehog signaling cascades .
7811304	0	mitoxantrone	24,36	myeloperoxidase	68,83	mitoxantrone	myeloperoxidase	MESH:D008942	4353	Chemical	Gene	metabolism|nmod|START_ENTITY END_ENTITY|nsubj|metabolism	Oxidative metabolism of mitoxantrone by the human neutrophil enzyme myeloperoxidase .
8171037	0	mixanpril	106,115	angiotensin-converting_enzyme	19,48	mixanpril	angiotensin-converting enzyme	null	24310(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Dual inhibition of angiotensin-converting_enzyme and neutral_endopeptidase by the orally active inhibitor mixanpril : a potential therapeutic approach in hypertension .
12518232	0	miyabenol_C	44,55	estrogen_receptor	22,39	miyabenol C	estrogen receptor	null	2099	Chemical	Gene	-RSB-|compound|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- The binding sites of estrogen_receptor for miyabenol_C and kobophenol_A -RSB- .
15725247	0	mizolastine	14,25	vascular_endothelial_cell_growth_factor	43,82	mizolastine	vascular endothelial cell growth factor	MESH:C076170	22339(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	The effect of mizolastine on expression of vascular_endothelial_cell_growth_factor , tumour necrosis factor-alpha and keratinocyte-derived chemokine in murine mast cells , compared with dexamethasone and loratadine .
10574997	0	mizoribine	59,69	HSP60	10,15	mizoribine	HSP60	MESH:C010052	3329	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Mammalian HSP60 is a major target for an immunosuppressant mizoribine .
10844522	0	mizoribine	80,90	cyclin_A	14,22	mizoribine	cyclin A	MESH:C010052	890	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|expression expression|compound|END_ENTITY	Inhibition of cyclin_A gene expression in human B cells by an immunosuppressant mizoribine .
7594527	0	mizoribine	78,88	cyclin_A	28,36	mizoribine	cyclin A	MESH:C010052	890	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of expression of cyclin_A in human B cells by an immunosuppressant mizoribine .
17029075	0	mizoribine	21,31	matrix_metalloproteinase-1	35,61	mizoribine	matrix metalloproteinase-1	MESH:C010052	4312	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|production production|amod|END_ENTITY	Inhibitory effect of mizoribine on matrix_metalloproteinase-1 production in synovial fibroblasts and THP-1 macrophages .
11309556	0	moclobemide	48,59	CYP2C19	101,108	moclobemide	CYP2C19	MESH:D020912	1557	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|polymorphism polymorphism|nmod|END_ENTITY	Effect of omeprazole on the pharmacokinetics of moclobemide according to the genetic polymorphism of CYP2C19 .
3574489	0	moclobemide	96,107	MAO	78,81	moclobemide	MAO	MESH:D020912	29253(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY END_ENTITY|acl|inhibition	Short-acting novel MAO inhibitors : in vitro evidence for the reversibility of MAO inhibition by moclobemide and Ro_16-6491 .
10333164	0	moclobemide	69,80	MAO-A	95,100	moclobemide	MAO-A	MESH:D020912	4128	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Undesirable blood pressure changes under naturalistic treatment with moclobemide , a reversible MAO-A inhibitor -- results of the drug utilization observation studies .
2089086	0	moclobemide	5,16	MAO-A	70,75	moclobemide	MAO-A	MESH:D020912	29253(Tax:10116)	Chemical	Gene	stimulate|nsubj|START_ENTITY stimulate|advcl|do do|nsubj|inhibitors inhibitors|compound|END_ENTITY	Does moclobemide stimulate melatonin synthesis as the other selective MAO-A inhibitors do ?
2193111	0	moclobemide	5,16	MAO-A	103,108	moclobemide	MAO-A	MESH:D020912	4128	Chemical	Gene	development|nmod|START_ENTITY development|nmod|END_ENTITY	From moclobemide to Ro_19-6327 and Ro 41-1049 : the development of a new class of reversible , selective MAO-A and MAO-B inhibitors .
2250565	0	moclobemide	45,56	MAO-A	29,34	moclobemide	MAO-A	MESH:D020912	4128	Chemical	Gene	START_ENTITY|nsubj|inhibitor inhibitor|amod|END_ENTITY	Evidence that the reversible MAO-A inhibitor moclobemide increases prolactin secretion by a serotonergic mechanism in healthy male volunteers .
2312783	0	moclobemide	24,35	MAO-A	43,48	moclobemide	MAO-A	MESH:D020912	4128	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Disposition kinetics of moclobemide , a new MAO-A inhibitor , in subjects with impaired_renal_function .
24921229	0	moclobemide	162,173	MAO-A	188,193	moclobemide	MAO-A	MESH:D020912	4128	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Assessment of sexual_dysfunction in depressed patients and reporting attitudes in routine daily practice : Results of the postmarketing observational studies with moclobemide , a reversible MAO-A inhibitor .
2587673	0	moclobemide	40,51	MAO-A	23,28	moclobemide	MAO-A	MESH:D020912	29253(Tax:10116)	Chemical	Gene	Comparison|amod|START_ENTITY Comparison|nmod|inhibitors inhibitors|amod|END_ENTITY	-LSB- Comparison of the new MAO-A inhibitors moclobemide , brofaromine and toloxatone with tranylcypromine in an animal experiment : significance for clinical practice -RSB- .
26316187	7	moclobemide	1506,1517	MAO-A	1553,1558	moclobemide	MAO-A	MESH:D020912	4128	Chemical	Gene	doses|compound|START_ENTITY doses|nmod|doses doses|amod|correspond correspond|nmod|occupancy occupancy|amod|END_ENTITY	CONCLUSIONS : These findings suggest that for first-line MDE treatment , daily moclobemide doses of 300-600mg correspond to a MAO-A occupancy of 74 % , whereas for treatment-resistant MDE , either phenelzine or higher doses of moclobemide correspond to a MAO-A occupancy of at least 84 % .
26316187	7	moclobemide	1651,1662	MAO-A	1553,1558	moclobemide	MAO-A	MESH:D020912	4128	Chemical	Gene	doses|nmod|START_ENTITY doses|amod|correspond correspond|nmod|occupancy occupancy|amod|END_ENTITY	CONCLUSIONS : These findings suggest that for first-line MDE treatment , daily moclobemide doses of 300-600mg correspond to a MAO-A occupancy of 74 % , whereas for treatment-resistant MDE , either phenelzine or higher doses of moclobemide correspond to a MAO-A occupancy of at least 84 % .
2677242	0	moclobemide	63,74	MAO-A	45,50	moclobemide	MAO-A	MESH:D020912	29253(Tax:10116)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Preclinical profiles of the novel reversible MAO-A inhibitors , moclobemide and brofaromine , in comparison with irreversible MAO inhibitors .
2685856	0	moclobemide	87,98	MAO-A	31,36	moclobemide	MAO-A	MESH:D020912	4128	Chemical	Gene	switch|nmod|START_ENTITY study|nmod|switch inhibitors|dep|study inhibitors|amod|END_ENTITY	-LSB- Treatment of depression using MAO-A inhibitors : an open study of a direct switch from moclobemide to tri - / tetracyclic antidepressants -RSB- .
4026902	0	moclobemide	82,93	MAO-A	66,71	moclobemide	MAO-A	MESH:D020912	29253(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|lack lack|nmod|hepatotoxicity hepatotoxicity|nmod|rat rat|nmod|inhibitor inhibitor|amod|END_ENTITY	The lack of hepatotoxicity in the rat with the new and reversible MAO-A inhibitor moclobemide in contrast to iproniazid .
6382361	0	moclobemide	61,72	MAO-A	80,85	moclobemide	MAO-A	MESH:D020912	4128	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	A placebo-controlled study of the antidepressant activity of moclobemide , a new MAO-A inhibitor .
7800155	0	moclobemide	56,67	MAO-A	40,45	moclobemide	MAO-A	MESH:D020912	4128	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|treatment treatment|nmod|inhibitor inhibitor|amod|END_ENTITY	Effects of long-term treatment with the MAO-A inhibitor moclobemide on sleep EEG and nocturnal hormonal secretion in normal men .
7905288	0	moclobemide	81,92	MAO-A	58,63	moclobemide	MAO-A	MESH:D020912	4128	Chemical	Gene	focus|nmod|START_ENTITY Biochemistry|dep|focus Biochemistry|nmod|inhibitors inhibitors|nmod|agents agents|amod|END_ENTITY	Biochemistry and pharmacology of reversible inhibitors of MAO-A agents : focus on moclobemide .
8614267	0	moclobemide	27,38	MAO-A	74,79	moclobemide	MAO-A	MESH:D020912	29253(Tax:10116)	Chemical	Gene	derivative|nmod|START_ENTITY radioligand|nsubj|derivative radioligand|nmod|exploration exploration|amod|END_ENTITY	An iodinated derivative of moclobemide as potential radioligand for brain MAO-A exploration .
8878071	0	moclobemide	62,73	MAO-A	98,103	moclobemide	MAO-A	MESH:D020912	17161(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Experimental anxiety and antidepressant drugs : the effects of moclobemide , a selective reversible MAO-A inhibitor , fluoxetine and imipramine in mice .
8378409	0	moclobemide	11,22	Mao-A	52,57	moclobemide	Mao-A	MESH:D020912	29253(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|generation generation|dep|inhibitor inhibitor|amod|END_ENTITY	Effects of moclobemide , a new generation reversible Mao-A inhibitor , in a novel animal model of depression .
7519866	0	moclobemide	51,62	Monoamine_oxidase-A	0,19	moclobemide	Monoamine oxidase-A	MESH:D020912	4128	Chemical	Gene	humans|nmod|START_ENTITY pharmacodynamics|nmod|humans END_ENTITY|dep|pharmacodynamics	Monoamine_oxidase-A : pharmacodynamics in humans of moclobemide , a reversible and selective inhibitor .
21463543	0	moclobemide	91,102	Monoamine_oxidase_A	0,19	moclobemide	Monoamine oxidase A	MESH:D020912	4128	Chemical	Gene	depressive_episodes|nmod|START_ENTITY treatment|nmod|depressive_episodes occupancy|nmod|treatment occupancy|compound|END_ENTITY	Monoamine_oxidase_A inhibitor occupancy during treatment of major depressive_episodes with moclobemide or St. John 's wort : an -LSB- 11C -RSB- - harmine PET study .
8880082	0	moclobemide	53,64	cytochrome_P450_2D6	12,31	moclobemide	cytochrome P450 2D6	MESH:D020912	1565	Chemical	Gene	metabolism|nmod|START_ENTITY role|nmod|metabolism role|nmod|END_ENTITY	The role of cytochrome_P450_2D6 in the metabolism of moclobemide .
1687486	0	moclobemide	47,58	monoamine-oxidase-A	87,106	moclobemide	monoamine-oxidase-A	MESH:D020912	4128	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Successful treatment of tardive_akathisia with moclobemide , a reversible and selective monoamine-oxidase-A inhibitor .
1546132	0	moclobemide	72,83	monoamine_oxidase-A	38,57	moclobemide	monoamine oxidase-A	MESH:D020912	4128	Chemical	Gene	Mode|nmod|START_ENTITY Mode|nmod|inhibition inhibition|amod|END_ENTITY	Mode of action and characteristics of monoamine_oxidase-A inhibition by moclobemide .
1705137	0	moclobemide	121,132	monoamine_oxidase-A	90,109	moclobemide	monoamine oxidase-A	MESH:D020912	4128	Chemical	Gene	properties|amod|START_ENTITY properties|nmod|inhibitors inhibitors|amod|END_ENTITY	Comparison of the monoamine oxidase inhibiting properties of two reversible and selective monoamine_oxidase-A inhibitors moclobemide and toloxatone , and assessment of their effect on psychometric performance in healthy subjects .
2123366	0	moclobemide	16,27	monoamine_oxidase-A	59,78	moclobemide	monoamine oxidase-A	MESH:D020912	4128	Chemical	Gene	Tolerability|nmod|START_ENTITY Tolerability|appos|inhibitor inhibitor|nmod|END_ENTITY	Tolerability of moclobemide , a new reversible inhibitor of monoamine_oxidase-A , compared with other antidepressants and placebo .
2248058	0	moclobemide	48,59	monoamine_oxidase-A	14,33	moclobemide	monoamine oxidase-A	MESH:D020912	29253(Tax:10116)	Chemical	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|inhibition inhibition|amod|END_ENTITY	Comparison of monoamine_oxidase-A inhibition by moclobemide in vitro and ex vivo in rats .
2248059	0	moclobemide	66,77	monoamine_oxidase-A	43,62	moclobemide	monoamine oxidase-A	MESH:D020912	29253(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Short-lasting and reversible inhibition of monoamine_oxidase-A by moclobemide .
2619974	0	moclobemide	54,65	monoamine_oxidase-A	23,42	moclobemide	monoamine oxidase-A	MESH:D020912	4128	Chemical	Gene	Effect|appos|START_ENTITY Effect|nmod|inhibitor inhibitor|amod|END_ENTITY	Effect of a reversible monoamine_oxidase-A inhibitor -LRB- moclobemide -RRB- on sleep of depressed patients .
3665338	0	moclobemide	24,35	monoamine_oxidase-A	39,58	moclobemide	monoamine oxidase-A	MESH:D020912	4128	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Disposition kinetics of moclobemide , a monoamine_oxidase-A enzyme inhibitor : single and multiple dosing in normal subjects .
8582117	0	moclobemide	63,74	monoamine_oxidase-A	33,52	moclobemide	monoamine oxidase-A	MESH:D020912	4128	Chemical	Gene	START_ENTITY|nsubj|pharmacokinetics pharmacokinetics|nmod|inhibitor inhibitor|amod|END_ENTITY	Clinical pharmacokinetics of the monoamine_oxidase-A inhibitor moclobemide .
8923574	0	moclobemide	42,53	monoamine_oxidase-A	8,27	moclobemide	monoamine oxidase-A	MESH:D020912	4128	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Initial monoamine_oxidase-A inhibition by moclobemide does not predict the therapeutic response in patients with major_depression .
11287054	0	moclobemide	45,56	monoamine_oxidase_A	15,34	moclobemide	monoamine oxidase A	MESH:D020912	17161(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|inhibitor inhibitor|compound|END_ENTITY	Effects of the monoamine_oxidase_A inhibitor moclobemide on hippocampal plasticity in GR-impaired transgenic_mice .
7586937	0	moclobemide	44,55	monoamine_oxidase_A	13,32	moclobemide	monoamine oxidase A	MESH:D020912	4128	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	A reversible monoamine_oxidase_A inhibitor -LRB- moclobemide -RRB- facilitates smoking cessation and abstinence in heavy , dependent smokers .
7593732	0	moclobemide	29,40	monoamine_oxidase_A	65,84	moclobemide	monoamine oxidase A	MESH:D020912	4128	Chemical	Gene	potential|nmod|START_ENTITY potential|appos|inhibitor inhibitor|compound|END_ENTITY	The therapeutic potential of moclobemide , a reversible selective monoamine_oxidase_A inhibitor in Parkinson 's _ disease .
8296582	2	moclobemide	106,117	monoamine_oxidase_A	76,95	moclobemide	monoamine oxidase A	MESH:D020912	4128	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|comparison comparison|nmod|END_ENTITY	A comparison of the selective monoamine_oxidase_A inhibitor moclobemide and placebo .
9579294	0	moclobemide	26,37	monoamine_oxidase_A	62,81	moclobemide	monoamine oxidase A	MESH:D020912	4128	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	The therapeutic effect of moclobemide , a reversible selective monoamine_oxidase_A inhibitor , in Parkinson 's _ disease .
10402091	0	modafinil	51,60	P300	7,11	modafinil	P300	MESH:C048833	2033	Chemical	Gene	predicts|advcl|START_ENTITY predicts|nsubj|END_ENTITY	Visual P300 latency predicts treatment response to modafinil in patients with narcolepsy .
17138067	0	modafinil	29,38	P300	0,4	modafinil	P300	MESH:C048833	2033	Chemical	Gene	effect|nmod|START_ENTITY effect|compound|END_ENTITY	P300 and treatment effect of modafinil on fatigue in multiple_sclerosis .
17082565	0	modulates	79,88	cyclooxygenase-2	89,105	modulates	cyclooxygenase-2	null	5743	Chemical	Gene	START_ENTITY|dobj|expression expression|amod|END_ENTITY	An environmental quinoid polycyclic_aromatic_hydrocarbon , acenaphthenequinone , modulates cyclooxygenase-2 expression through reactive oxygen species generation and nuclear_factor_kappa_B activation in A549 cells .
14728069	0	moexipril	20,29	ACE	0,3	moexipril	ACE	MESH:C058302	1636	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|compound|END_ENTITY	ACE Inhibition with moexipril : a review of potential effects beyond blood pressure control .
7564369	0	moexipril	28,37	ACE	45,48	moexipril	ACE	MESH:C058302	1636	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|inhibitor inhibitor|compound|END_ENTITY	Antihypertensive effects of moexipril , a new ACE inhibitor , as add-on therapy to nifedipine in patients with essential hypertension .
7608310	0	moexipril	59,68	ACE	44,47	moexipril	ACE	MESH:C058302	1636	Chemical	Gene	assessment|amod|START_ENTITY assessment|nmod|efficacy efficacy|nmod|END_ENTITY	Tricenter assessment of the efficacy of the ACE inhibitor , moexipril , by ambulatory blood pressure monitoring .
7619356	0	moexipril	14,23	ACE	31,34	moexipril	ACE	MESH:C058302	1636	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Comparison of moexipril , a new ACE inhibitor , to verapamil-SR as add-on therapy to low dose hydrochlorothiazide in hypertensive patients .
8803515	0	moexipril	64,73	ACE	81,84	moexipril	ACE	MESH:C058302	1636	Chemical	Gene	efficacy|nmod|START_ENTITY Evaluation|nmod|efficacy Evaluation|appos|inhibitor inhibitor|compound|END_ENTITY	Evaluation of the antihypertensive efficacy and tolerability of moexipril , a new ACE inhibitor , compared to hydrochlorothiazide in elderly patients .
9643274	0	moexipril	151,160	ACE	136,139	moexipril	ACE	MESH:C058302	1636	Chemical	Gene	inhibitor|dep|START_ENTITY inhibitor|compound|END_ENTITY	Antihypertensive treatment in postmenopausal women : results from a prospective , randomized , double-blind , controlled study comparing an ACE inhibitor -LRB- moexipril -RRB- with a diuretic -LRB- hydrochlorothiazide -RRB- .
17159885	0	moexipril	41,50	Angiotensin_converting_enzyme	1,30	moexipril	Angiotensin converting enzyme	MESH:C058302	1636	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|END_ENTITY	-LSB- Angiotensin_converting_enzyme inhibitor moexipril in the treatment of arterial hypertension .
19053775	0	mofegiline	38,48	monoamine_oxidase_B	81,100	mofegiline	monoamine oxidase B	MESH:C058000	4129	Chemical	Gene	inhibition|amod|START_ENTITY studies|nmod|inhibition studies|nmod|END_ENTITY	Structural and mechanistic studies of mofegiline inhibition of recombinant human monoamine_oxidase_B .
7835226	0	mofegiline	31,41	monoamine_oxidase_B	59,78	mofegiline	monoamine oxidase B	MESH:C058000	403451(Tax:9615)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Novel carbamate metabolites of mofegiline , a primary_amine monoamine_oxidase_B inhibitor , in dogs and humans .
23000442	0	mollugin	32,40	CYP1A2	44,50	mollugin	CYP1A2	MESH:C046245	1544	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Selective inhibitory effects of mollugin on CYP1A2 in human liver microsomes .
21236252	0	mollugin	49,57	heme_oxygenase-1	79,95	mollugin	heme oxygenase-1	MESH:C046245	15368(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|cells cells|amod|END_ENTITY	Neuroprotective and anti-inflammatory effects of mollugin via up-regulation of heme_oxygenase-1 in mouse hippocampal and microglial cells .
11159004	0	molsidomine	13,24	endothelin-1	33,45	molsidomine	endothelin-1	MESH:D008981	24323(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|amod|END_ENTITY	The NO donor molsidomine reduces endothelin-1 gene expression in chronic hypoxic rat lungs .
9931095	0	molsidomine	52,63	endothelin-1	21,33	molsidomine	endothelin-1	MESH:D008981	24323(Tax:10116)	Chemical	Gene	interaction|nmod|START_ENTITY effects|dep|interaction effects|nmod|END_ENTITY	Inotropic effects of endothelin-1 : interaction with molsidomine and with BQ_610 .
14514295	0	molybdenum	78,88	sulfite_oxidase	97,112	molybdenum	sulfite oxidase	MESH:D008982	6821	Chemical	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Synthesis and EPR characterization of new models for the one-electron reduced molybdenum site of sulfite_oxidase .
15606194	0	molybdenum	30,40	sulfite_oxidase	49,64	molybdenum	sulfite oxidase	MESH:D008982	6821	Chemical	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Coordination chemistry at the molybdenum site of sulfite_oxidase : redox-induced structural changes in the cysteine_207_to_serine mutant .
21894921	0	molybdenum	32,42	sulfite_oxidase	51,66	molybdenum	sulfite oxidase	MESH:D008982	6821	Chemical	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Nature of halide binding to the molybdenum site of sulfite_oxidase .
2002036	0	molybdopterin	13,26	sulfite_oxidase	30,45	molybdopterin	sulfite oxidase	MESH:C022261	81805(Tax:10116)	Chemical	Gene	Oxidation|nmod|START_ENTITY Oxidation|nmod|END_ENTITY	Oxidation of molybdopterin in sulfite_oxidase by ferricyanide .
23954466	0	monascin	51,59	Nrf2	16,20	monascin	Nrf2	MESH:C517880	83619(Tax:10116)	Chemical	Gene	activator|appos|START_ENTITY activator|amod|END_ENTITY	A novel natural Nrf2 activator with PPARy-agonist -LRB- monascin -RRB- attenuates the toxicity of methylglyoxal and hyperglycemia .
7848617	0	monatepil	57,66	LDL_receptor	25,37	monatepil	LDL receptor	MESH:C067818	3949	Chemical	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|expression expression|compound|END_ENTITY	Up-regulation of hepatic LDL_receptor gene expression by monatepil , a novel calcium antagonist , in high cholesterol diet-fed Japanese monkeys .
9512869	0	monatepil	11,20	low-density_lipoprotein_receptor	99,131	monatepil	low-density lipoprotein receptor	MESH:C067818	3949	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of monatepil , a novel calcium antagonist with alpha 1-adrenergic blocking activity , on the low-density_lipoprotein_receptor in human skin fibroblasts .
2874833	0	monensin	77,85	lysyl_oxidase	13,26	monensin	lysyl oxidase	MESH:D008985	4015	Chemical	Gene	Secretion|nmod|START_ENTITY Secretion|nmod|END_ENTITY	Secretion of lysyl_oxidase by cultured human skin fibroblasts and effects of monensin , nigericin , tunicamycin and colchicine .
2821913	0	monensin	43,51	myeloperoxidase	113,128	monensin	myeloperoxidase	MESH:D008985	4353	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|cells cells|amod|END_ENTITY	Biochemical and ultrastructural effects of monensin on the processing , intracellular transport , and packaging of myeloperoxidase into low and high density compartments of human leukemia -LRB- HL-60 -RRB- cells .
6386182	0	monensin	117,125	proinsulin	87,97	monensin	proinsulin	MESH:D008985	3630	Chemical	Gene	presence|nmod|START_ENTITY accumulates|nmod|presence accumulates|dobj|END_ENTITY	A clathrin-coated , Golgi-related compartment of the insulin secreting cell accumulates proinsulin in the presence of monensin .
6391571	0	monensin	11,19	proinsulin	68,78	monensin	proinsulin	MESH:D008985	3630	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of monensin on biosynthesis and intracellular processing of proinsulin .
2516782	0	monensin	10,18	t-PA	35,39	monensin	t-PA	MESH:D008985	5327	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of monensin on secretion of t-PA from melanoma -LRB- Bowes -RRB- .
2753202	0	monoacyl	29,37	Phospholipase_A2	0,16	monoacyl	Phospholipase A2	null	151056	Chemical	Gene	inhibitors|dep|START_ENTITY inhibitors|amod|END_ENTITY	Phospholipase_A2 inhibitors : monoacyl , monoacylamino-glycero-phosphocholines .
12576479	0	monoacylglycerol	71,87	MGAT2	105,110	monoacylglycerol	MGAT2	CHEBI:17408	217664(Tax:10090)	Chemical	Gene	acyltransferase|amod|START_ENTITY acyltransferase|appos|END_ENTITY	Cloning and functional characterization of a mouse intestinal acyl-CoA : monoacylglycerol acyltransferase , MGAT2 .
12730219	0	monoacylglycerol	44,60	MGAT2	78,83	monoacylglycerol	MGAT2	CHEBI:17408	217664(Tax:10090)	Chemical	Gene	acyltransferase|amod|START_ENTITY acyltransferase|appos|END_ENTITY	Properties of the mouse intestinal acyl-CoA : monoacylglycerol acyltransferase , MGAT2 .
15627655	0	monoacylglycerol	63,79	hormone-sensitive_lipase	20,44	monoacylglycerol	hormone-sensitive lipase	CHEBI:17408	25330(Tax:10116)	Chemical	Gene	using|dobj|START_ENTITY END_ENTITY|acl|using	Sensitive assay for hormone-sensitive_lipase using NBD-labeled monoacylglycerol to detect low activities in rat adipocytes .
26041338	0	monoamine	39,48	5-HT2C	8,14	monoamine	5-HT2C	CHEBI:25375	25187(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY receptors|nmod|effects receptors|nummod|END_ENTITY	Role of 5-HT2C receptors in effects of monoamine releasers on intracranial self-stimulation in rats .
2423144	0	monoamine	32,41	CSF	28,31	monoamine	CSF	CHEBI:25375	1437	Chemical	Gene	START_ENTITY|nsubj|variations variations|nmod|END_ENTITY	Developmental variations in CSF monoamine metabolites during childhood .
12538837	0	monoamine	52,61	EMT	112,115	monoamine	EMT	CHEBI:25375	3702	Chemical	Gene	_|compound|START_ENTITY _|appos|END_ENTITY	Agmatine is efficiently transported by non-neuronal monoamine transporters extraneuronal_monoamine_transporter _ -LRB- EMT -RRB- and organic_cation_transporter_2 -LRB- OCT2 -RRB- .
8477053	0	monoamine	24,33	Interleukin-2	0,13	monoamine	Interleukin-2	CHEBI:25375	116562(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY regulates|dobj|release regulates|nsubj|END_ENTITY	Interleukin-2 regulates monoamine and opioid peptide release from the hypothalamus .
24156742	0	monoamine	6,15	MAO	25,28	monoamine	MAO	CHEBI:25375	29253(Tax:10116)	Chemical	Gene	oxidase|compound|START_ENTITY oxidase|appos|END_ENTITY	Total monoamine oxidase -LRB- MAO -RRB- inhibition by chestnut honey , pollen and propolis .
12951422	0	monoamine	28,37	MAOA	58,62	monoamine	MAOA	CHEBI:25375	4128	Chemical	Gene	oxidase|compound|START_ENTITY cloning|nmod|oxidase subtypes|nsubj|cloning subtypes|dobj|A A|appos|END_ENTITY	Molecular cloning of canine monoamine oxidase subtypes A -LRB- MAOA -RRB- and B -LRB- MAOB -RRB- cDNAs and their expression in the brain .
16893905	0	monoamine	36,45	MAOA	57,61	monoamine	MAOA	CHEBI:25375	4128	Chemical	Gene	expression|nmod|START_ENTITY oxidase|nsubj|expression oxidase|dobj|END_ENTITY	Allelic mRNA expression of X-linked monoamine oxidase a -LRB- MAOA -RRB- in human brain : dissection of epigenetic and genetic factors .
2906043	0	monoamine	6,15	MAOA	30,34	monoamine	MAOA	CHEBI:25375	4128	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Human monoamine oxidase gene -LRB- MAOA -RRB- : chromosome position -LRB- Xp21-p11 -RRB- and DNA polymorphism .
11118898	0	monoamine	18,27	Maoa	76,80	monoamine	Maoa	CHEBI:25375	17161(Tax:10090)	Chemical	Gene	Slc22a3/Orct3|amod|START_ENTITY co-localizes|nsubj|Slc22a3/Orct3 co-localizes|nmod|enzyme enzyme|compound|END_ENTITY	The extraneuronal monoamine transporter Slc22a3/Orct3 co-localizes with the Maoa metabolizing enzyme in mouse placenta .
12538837	0	monoamine	52,61	OCT2	151,155	monoamine	OCT2	CHEBI:25375	6582	Chemical	Gene	_|compound|START_ENTITY _|appos|END_ENTITY	Agmatine is efficiently transported by non-neuronal monoamine transporters extraneuronal_monoamine_transporter _ -LRB- EMT -RRB- and organic_cation_transporter_2 -LRB- OCT2 -RRB- .
9830022	0	monoamine	69,78	OCT3	43,47	monoamine	OCT3	CHEBI:25375	6581	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|nmod|transporter	Identity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter -LRB- uptake2 -RRB- and evidence for the expression of the transporter in the brain .
17046718	0	monoamine	60,69	PMAT	83,87	monoamine	PMAT	CHEBI:25375	222962	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Evidence for significant contribution of a newly identified monoamine transporter -LRB- PMAT -RRB- to serotonin uptake in the human brain .
12768439	0	monoamine	41,50	SLC22A3	68,75	monoamine	SLC22A3	CHEBI:25375	6581	Chemical	Gene	START_ENTITY|dobj|EMT EMT|appos|END_ENTITY	Genetic variability of the extraneuronal monoamine transporter EMT -LRB- SLC22A3 -RRB- .
17727882	0	monoamine	109,118	SLC22A3	132,139	monoamine	SLC22A3	CHEBI:25375	6581	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Enhanced norepinephrine output during long-term desipramine treatment : a possible role for the extraneuronal monoamine transporter -LRB- SLC22A3 -RRB- .
11443533	0	monoamine	119,128	SVMT	142,146	monoamine	SVMT	CHEBI:25375	6571	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Exon/intron boundaries , novel polymorphisms , and association analysis with schizophrenia of the human synaptic vesicle monoamine transporter -LRB- SVMT -RRB- gene .
17427184	0	monoamine	101,110	SVMT	129,133	monoamine	SVMT	CHEBI:25375	6571	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of two risk haplotypes for schizophrenia and bipolar_disorder in the synaptic vesicle monoamine transporter gene -LRB- SVMT -RRB- .
23255610	0	monoamine	119,128	Slc29a4	142,149	monoamine	Slc29a4	CHEBI:25375	243328(Tax:10090)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Impaired monoamine and organic cation uptake in choroid_plexus in mice with targeted disruption of the plasma membrane monoamine transporter -LRB- Slc29a4 -RRB- gene .
23255610	0	monoamine	9,18	Slc29a4	142,149	monoamine	Slc29a4	CHEBI:25375	243328(Tax:10090)	Chemical	Gene	uptake|nsubj|START_ENTITY uptake|nmod|disruption disruption|nmod|gene gene|appos|END_ENTITY	Impaired monoamine and organic cation uptake in choroid_plexus in mice with targeted disruption of the plasma membrane monoamine transporter -LRB- Slc29a4 -RRB- gene .
21712771	0	monoamine	10,19	VMAT-1	35,41	monoamine	VMAT-1	CHEBI:25375	110877(Tax:10090)	Chemical	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Vesicular monoamine transporter-1 -LRB- VMAT-1 -RRB- mRNA and immunoreactive proteins in mouse brain .
9673797	0	monoamine	73,82	VMAT1	103,108	monoamine	VMAT1	CHEBI:25375	25693(Tax:10116)	Chemical	Gene	immunoreactivity|compound|START_ENTITY immunoreactivity|compound|END_ENTITY	Cutaneous Merkel cells of the rat contain both dynorphin A and vesicular monoamine transporter type 1 -LRB- VMAT1 -RRB- immunoreactivity .
10192785	0	monoamine	37,46	VMAT2	60,65	monoamine	VMAT2	CHEBI:25375	6571	Chemical	Gene	START_ENTITY|dobj|protein protein|appos|END_ENTITY	Immunochemical analysis of vesicular monoamine transporter -LRB- VMAT2 -RRB- protein in Parkinson 's _ disease .
10772999	0	monoamine	63,72	VMAT2	86,91	monoamine	VMAT2	CHEBI:25375	25549(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|transporter transporter|appos|END_ENTITY	In vitro studies of striatal vesicles containing the vesicular monoamine transporter -LRB- VMAT2 -RRB- : rat versus mouse differences in sequestration of 1-methyl-4-phenylpyridinium .
10773000	0	monoamine	30,39	VMAT2	53,58	monoamine	VMAT2	CHEBI:25375	25549(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY Inhibition|nmod|transporter Inhibition|appos|END_ENTITY	Inhibition of brain vesicular monoamine transporter -LRB- VMAT2 -RRB- enhances 1-methyl-4-phenylpyridinium neurotoxicity in vivo in rat striata .
11702019	0	monoamine	21,30	VMAT2	44,49	monoamine	VMAT2	CHEBI:25375	25549(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Changes in vesicular monoamine transporter -LRB- VMAT2 -RRB- and synaptophysin in rat Substantia nigra and prefrontal cortex induced by psychotropic drugs .
12009896	0	monoamine	32,41	VMAT2	55,60	monoamine	VMAT2	CHEBI:25375	6571	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Identification of human vesicle monoamine transporter -LRB- VMAT2 -RRB- lumenal cysteines that form an intramolecular disulfide bond .
12112404	0	monoamine	81,90	VMAT2	106,111	monoamine	VMAT2	CHEBI:25375	6571	Chemical	Gene	START_ENTITY|dobj|2 2|appos|END_ENTITY	Region-specific targeting of dopamine D2-receptors and somatodendritic vesicular monoamine transporter 2 -LRB- VMAT2 -RRB- within ventral tegmental area subdivisions .
12604601	0	monoamine	14,23	VMAT2	42,47	monoamine	VMAT2	CHEBI:25375	214084(Tax:10090)	Chemical	Gene	content|compound|START_ENTITY regulates|nsubj|content regulates|dobj|activity activity|compound|END_ENTITY	The vesicular monoamine content regulates VMAT2 activity through Galphaq in mouse platelets .
17156758	0	monoamine	53,62	VMAT2	76,81	monoamine	VMAT2	CHEBI:25375	25549(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|transporter transporter|appos|END_ENTITY	Different subcellular distributions of the vesicular monoamine transporter , VMAT2 , in subclasses of sympathetic neurons .
18815269	0	monoamine	20,29	VMAT2	109,114	monoamine	VMAT2	CHEBI:25375	6571	Chemical	Gene	transporter|compound|START_ENTITY binding|dep|transporter binding|nmod|abstinence abstinence|nmod|users users|dep|biomarker biomarker|nsubj|END_ENTITY	Increased vesicular monoamine transporter binding during early abstinence in human methamphetamine users : Is VMAT2 a stable dopamine neuron biomarker ?
19691331	0	monoamine	133,142	VMAT2	158,163	monoamine	VMAT2	CHEBI:25375	6571	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Pyrrolidine analogues of lobelane : relationship of affinity for the dihydrotetrabenazine binding site with function of the vesicular monoamine transporter 2 -LRB- VMAT2 -RRB- .
21046458	0	monoamine	10,19	VMAT2	100,105	monoamine	VMAT2	CHEBI:25375	25549(Tax:10116)	Chemical	Gene	transporters|compound|START_ENTITY transporters|dep|induction induction|nmod|END_ENTITY	Vesicular monoamine transporters -LRB- VMATs -RRB- in adrenal chromaffin cells : stress-triggered induction of VMAT2 and expression in epinephrine synthesizing cells .
21531556	0	monoamine	93,102	VMAT2	118,123	monoamine	VMAT2	CHEBI:25375	25549(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|ligands ligands|appos|END_ENTITY	Synthesis and biological evaluation of 3-alkyl-dihydrotetrabenazine derivatives as vesicular monoamine transporter-2 -LRB- VMAT2 -RRB- ligands .
22193525	0	monoamine	44,53	VMAT2	69,74	monoamine	VMAT2	CHEBI:25375	6571	Chemical	Gene	START_ENTITY|dobj|2 2|appos|END_ENTITY	In vivo evidence for low striatal vesicular monoamine transporter 2 -LRB- VMAT2 -RRB- availability in cocaine_abusers .
6593325	0	monoamine	51,60	catechol-O-methyltransferase	12,40	monoamine	catechol-O-methyltransferase	CHEBI:25375	1312	Chemical	Gene	oxidase|compound|START_ENTITY oxidase|amod|END_ENTITY	Erythrocyte catechol-O-methyltransferase , platelet monoamine oxidase , and platelet phenol sulfotransferase activities in patients with prolactin-secreting pituitary_adenomas .
6641500	0	monoamine	9,18	catechol-o-methyltransferase	43,71	monoamine	catechol-o-methyltransferase	CHEBI:25375	1312	Chemical	Gene	START_ENTITY|dobj|activity activity|amod|END_ENTITY	Platelet monoamine oxidase and erythrocyte catechol-o-methyltransferase activity in alcoholism and controlled abstinence .
11300710	0	monoamine	17,26	corticotropin-releasing_factor	62,92	monoamine	corticotropin-releasing factor	CHEBI:25375	1392	Chemical	Gene	levels|amod|START_ENTITY levels|nmod|administration administration|nmod|END_ENTITY	Rapid changes in monoamine levels following administration of corticotropin-releasing_factor or corticosterone are localized in the dorsomedial hypothalamus .
2476695	0	monoamine	48,57	corticotropin-releasing_factor	14,44	monoamine	corticotropin-releasing factor	CHEBI:25375	81648(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY END_ENTITY|nmod|metabolism	Modulation by corticotropin-releasing_factor of monoamine metabolism in the lateral hypothalamus .
3876519	0	monoamine	154,163	corticotropin-releasing_factor	59,89	monoamine	corticotropin-releasing factor	CHEBI:25375	81648(Tax:10116)	Chemical	Gene	contents|amod|START_ENTITY influence|nmod|contents lack|nmod|influence Effects|dep|lack Effects|nmod|administration administration|nmod|END_ENTITY	Effects of intracerebroventricular administration of ovine corticotropin-releasing_factor -LRB- CRF_1-41 -RRB- on passive avoidance behaviour : lack of influence on monoamine contents of limbic brain areas .
1792858	0	monoamine	9,18	dopamine-beta-hydroxylase	38,63	monoamine	dopamine-beta-hydroxylase	CHEBI:25375	1621	Chemical	Gene	START_ENTITY|dobj|activities activities|amod|END_ENTITY	Platelet monoamine oxidase and plasma dopamine-beta-hydroxylase activities in patients with multiple_sclerosis .
3608795	0	monoamine	9,18	dopamine-beta-hydroxylase	38,63	monoamine	dopamine-beta-hydroxylase	CHEBI:25375	1621	Chemical	Gene	START_ENTITY|dobj|activities activities|amod|END_ENTITY	Platelet monoamine oxidase and plasma dopamine-beta-hydroxylase activities in non-abstinent chronic alcoholics .
697539	0	monoamine	9,18	dopamine-beta-hydroxylase	37,62	monoamine	dopamine-beta-hydroxylase	CHEBI:25375	1621	Chemical	Gene	START_ENTITY|dobj|activity activity|amod|END_ENTITY	Platelet monoamine oxidase and serum dopamine-beta-hydroxylase activity in chronic alcoholics .
824661	0	monoamine	51,60	dopamine-beta-hydroxylase	85,110	monoamine	dopamine-beta-hydroxylase	CHEBI:25375	574105(Tax:9544)	Chemical	Gene	oxidase|compound|START_ENTITY oxidase|dep|END_ENTITY	The effects of testosterone on plasma and platelet monoamine oxidase -LRB- MAO -RRB- an plasma dopamine-beta-hydroxylase -LRB- DBH -RRB- activities in the male rhesus_monkey .
8771233	0	monoamine	20,29	dopamine-beta-hydroxylase	49,74	monoamine	dopamine-beta-hydroxylase	CHEBI:25375	1621	Chemical	Gene	START_ENTITY|dobj|activities activities|amod|END_ENTITY	Changes in platelet monoamine oxidase and plasma dopamine-beta-hydroxylase activities in lithium-treated bipolar patients .
15246838	0	monoamine	93,102	dopamine_transporter	58,78	monoamine	dopamine transporter	CHEBI:25375	24898(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|scopolamine scopolamine|nmod|END_ENTITY	Differential effects of scopolamine on in vivo binding of dopamine_transporter and vesicular monoamine transporter radioligands in rat brain .
23468413	0	monoamine	61,70	dopamine_transporter	26,46	monoamine	dopamine transporter	CHEBI:25375	6531	Chemical	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Coordinated expression of dopamine_transporter and vesicular monoamine transporter in the primate striatum during development .
24239329	0	monoamine	28,37	dopamine_transporter	85,105	monoamine	dopamine transporter	CHEBI:25375	6531	Chemical	Gene	START_ENTITY|nmod|effects effects|dep|occupancy occupancy|compound|END_ENTITY	Tesofensine , a novel triple monoamine re-uptake inhibitor with anti-obesity effects : dopamine_transporter occupancy as measured by PET .
7870046	0	monoamine	123,132	dopamine_transporter	85,105	monoamine	dopamine transporter	CHEBI:25375	6531	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|nmod|transporter	Mechanism of the dopamine-releasing actions of amphetamine and cocaine : plasmalemmal dopamine_transporter versus vesicular monoamine transporter .
8627383	0	monoamine	14,23	dopamine_transporter	56,76	monoamine	dopamine transporter	CHEBI:25375	24898(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|nmod|contrast contrast|nmod|END_ENTITY	The vesicular monoamine transporter , in contrast to the dopamine_transporter , is not altered by chronic cocaine self-administration in the rat .
16928864	0	monoamine	25,34	organic_cation_transporter_3	101,129	monoamine	organic cation transporter 3	CHEBI:25375	29504(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY transport|dep|role role|nmod|END_ENTITY	Corticosterone-sensitive monoamine transport in the rat dorsomedial hypothalamus : potential role for organic_cation_transporter_3 in stress-induced modulation of monoaminergic neurotransmission .
19025979	0	monoamine	73,82	organic_cation_transporter_3	16,44	monoamine	organic cation transporter 3	CHEBI:25375	29504(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|appos|transporter	Distribution of organic_cation_transporter_3 , a corticosterone-sensitive monoamine transporter , in the rat brain .
109886	0	monoamine	30,39	prolactin	61,70	monoamine	prolactin	CHEBI:25375	24683(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|levels levels|compound|END_ENTITY	Effects of piracetam on brain monoamine metabolism and serum prolactin levels in the rat .
317700	0	monoamine	71,80	prolactin	6,15	monoamine	prolactin	CHEBI:25375	24683(Tax:10116)	Chemical	Gene	inhibition|amod|START_ENTITY monoamine|nmod|inhibition monoamine|nsubj|END_ENTITY	Serum prolactin and brain and pituitary monoamine responses to chronic monoamine oxidase inhibition in the rat .
6116730	0	monoamine	23,32	somatostatin	44,56	monoamine	somatostatin	CHEBI:25375	6750	Chemical	Gene	release|compound|START_ENTITY release|nmod|END_ENTITY	-LSB- Facilitation of brain monoamine release by somatostatin and its mechanisms -LRB- author 's transl -RRB- -RSB- .
21354322	0	monoamine	56,65	zMAO	75,79	monoamine	zMAO	CHEBI:25375	404730(Tax:7955)	Chemical	Gene	oxidase|compound|START_ENTITY oxidase|appos|END_ENTITY	Catalytic and inhibitor binding properties of zebrafish monoamine oxidase -LRB- zMAO -RRB- : comparisons with human MAO_A and MAO_B .
1816091	0	monoamines	66,76	insulin	49,56	monoamines	insulin	CHEBI:25375	3630	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of intracerebroventricularly administered insulin on brain monoamines and acetylcholine in euglycaemic and alloxan-induced hyperglycaemic rats .
3912671	0	monoamines	13,23	luteinizing_hormone-releasing_hormone	38,75	monoamines	luteinizing hormone-releasing hormone	CHEBI:25375	25194(Tax:10116)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of monoamines on content of luteinizing_hormone-releasing_hormone in different regions of the hypothalamus of male rats .
6827269	0	monoamines	46,56	vasoactive_intestinal_polypeptide	11,44	monoamines	vasoactive intestinal polypeptide	CHEBI:25375	117064(Tax:10116)	Chemical	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of vasoactive_intestinal_polypeptide , monoamines , prostaglandins , and 2-chloroadenosine on adenylate cyclase in rat cerebral microvessels .
12039584	0	monobenzamidines	30,46	factor_Xa	73,82	monobenzamidines	factor Xa	null	2159	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Design , synthesis , and SAR of monobenzamidines and aminoisoquinolines as factor_Xa inhibitors .
14729246	0	monocarboxylate	26,41	GLUT1	90,95	monocarboxylate	GLUT1	CHEBI:35757	24778(Tax:10116)	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Correlation between local monocarboxylate transporter 1 -LRB- MCT1 -RRB- and glucose_transporter_1 -LRB- GLUT1 -RRB- densities in the adult rat brain .
19129673	0	monocarboxylate	33,48	GLUT1	112,117	monocarboxylate	GLUT1	CHEBI:35757	20525(Tax:10090)	Chemical	Gene	transporter|amod|START_ENTITY demonstration|nmod|transporter perineurium|nsubj|demonstration perineurium|nmod|END_ENTITY	Histochemical demonstration of a monocarboxylate transporter in the mouse perineurium with special reference to GLUT1 .
9447934	0	monocarboxylate	26,41	MCT	55,58	monocarboxylate	MCT	CHEBI:35757	6566	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Functional evidence for a monocarboxylate transporter -LRB- MCT -RRB- in strial marginal cells and molecular evidence for MCT1 and MCT2 in stria vascularis .
10392858	0	monocarboxylate	16,31	MCT1	45,49	monocarboxylate	MCT1	CHEBI:35757	25027(Tax:10116)	Chemical	Gene	Distribution|nmod|START_ENTITY transporters|nsubj|Distribution transporters|dobj|END_ENTITY	Distribution of monocarboxylate transporters MCT1 and MCT2 in rat retina .
10981713	0	monocarboxylate	55,70	MCT1	86,90	monocarboxylate	MCT1	CHEBI:35757	25027(Tax:10116)	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Lactate transport in rat adipocytes : identification of monocarboxylate transporter 1 -LRB- MCT1 -RRB- and its modulation during streptozotocin-induced diabetes .
11098125	0	monocarboxylate	30,45	MCT1	60,64	monocarboxylate	MCT1	CHEBI:35757	17236(Tax:10090)	Chemical	Gene	transporters|amod|START_ENTITY transporters|appos|END_ENTITY	Cell-specific localization of monocarboxylate transporters , MCT1 and MCT2 , in the adult mouse brain revealed by double immunohistochemical labeling and confocal microscopy .
11248400	0	monocarboxylate	31,46	MCT1	60,64	monocarboxylate	MCT1	CHEBI:35757	25027(Tax:10116)	Chemical	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Diet-induced ketosis increases monocarboxylate transporter -LRB- MCT1 -RRB- levels in rat brain .
11882670	0	monocarboxylate	50,65	MCT1	79,83	monocarboxylate	MCT1	CHEBI:35757	6566	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Substrate-induced regulation of the human colonic monocarboxylate transporter , MCT1 .
11944921	0	monocarboxylate	10,25	MCT1	39,43	monocarboxylate	MCT1	CHEBI:35757	6566	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	The human monocarboxylate transporter , MCT1 : genomic organization and promoter analysis .
12492781	0	monocarboxylate	16,31	MCT1	53,57	monocarboxylate	MCT1	CHEBI:35757	780423(Tax:9823)	Chemical	Gene	transporter|amod|START_ENTITY Distribution|nmod|transporter isoforms|nsubj|Distribution isoforms|dobj|END_ENTITY	Distribution of monocarboxylate transporter isoforms MCT1 , MCT2 and MCT4 in porcine muscles .
14729246	0	monocarboxylate	26,41	MCT1	57,61	monocarboxylate	MCT1	CHEBI:35757	25027(Tax:10116)	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Correlation between local monocarboxylate transporter 1 -LRB- MCT1 -RRB- and glucose_transporter_1 -LRB- GLUT1 -RRB- densities in the adult rat brain .
15450186	0	monocarboxylate	105,120	MCT1	100,104	monocarboxylate	MCT1	CHEBI:35757	25027(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|nummod|END_ENTITY	Co-expression of a mammalian accessory trafficking protein enables functional expression of the rat MCT1 monocarboxylate transporter in Saccharomyces_cerevisiae .
15682832	0	monocarboxylate	36,51	MCT1	65,69	monocarboxylate	MCT1	CHEBI:35757	25027(Tax:10116)	Chemical	Gene	localization|nmod|START_ENTITY transporters|nsubj|localization transporters|dobj|END_ENTITY	Fiber type-specific localization of monocarboxylate transporters MCT1 and MCT4 in rat skeletal muscle .
15804185	0	monocarboxylate	25,40	MCT1	54,58	monocarboxylate	MCT1	CHEBI:35757	6566	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Functional activity of a monocarboxylate transporter , MCT1 , in the human retinal_pigmented_epithelium cell line , ARPE-19 .
17611355	0	monocarboxylate	14,29	MCT1	45,49	monocarboxylate	MCT1	CHEBI:35757	475856(Tax:9615)	Chemical	Gene	transporter|compound|START_ENTITY Expression|nmod|transporter Expression|appos|END_ENTITY	Expression of monocarboxylate transporter 1 -LRB- MCT1 -RRB- in the dog intestine .
17786924	0	monocarboxylate	14,29	MCT1	45,49	monocarboxylate	MCT1	CHEBI:35757	6566	Chemical	Gene	transporter|compound|START_ENTITY Regulation|nmod|transporter Regulation|appos|END_ENTITY	Regulation of monocarboxylate transporter 1 -LRB- MCT1 -RRB- promoter by butyrate in human intestinal epithelial cells : involvement of NF-kappaB pathway .
19118535	0	monocarboxylate	23,38	MCT1	51,55	monocarboxylate	MCT1	CHEBI:35757	25027(Tax:10116)	Chemical	Gene	transporter|amod|START_ENTITY densities|nmod|transporter END_ENTITY|nsubj|densities	Increased densities of monocarboxylate transporter MCT1 after chronic hyperglycemia in rat brain .
19433117	0	monocarboxylate	23,38	MCT1	57,61	monocarboxylate	MCT1	CHEBI:35757	25027(Tax:10116)	Chemical	Gene	protein|amod|START_ENTITY densities|nmod|protein END_ENTITY|nsubj|densities	Increased densities of monocarboxylate transport protein MCT1 after chronic administration of nicotine in rat brain .
24885736	0	monocarboxylate	20,35	MCT1	122,126	monocarboxylate	MCT1	CHEBI:35757	6566	Chemical	Gene	transporters|amod|START_ENTITY expression|compound|transporters Characterization|nmod|expression Characterization|dep|impact impact|nmod|localization localization|compound|END_ENTITY	Characterization of monocarboxylate transporters -LRB- MCTs -RRB- expression in soft tissue sarcomas : distinct prognostic impact of MCT1 sub-cellular localization .
27026015	0	monocarboxylate	12,27	MCT1	40,44	monocarboxylate	MCT1	CHEBI:35757	6566	Chemical	Gene	transporter|amod|START_ENTITY Role|nmod|transporter END_ENTITY|nsubj|Role	Role of the monocarboxylate transporter MCT1 in the uptake of lactate during active recovery .
7548134	0	monocarboxylate	24,39	MCT1	16,20	monocarboxylate	MCT1	CHEBI:35757	25027(Tax:10116)	Chemical	Gene	transporter|amod|START_ENTITY cloning|appos|transporter cloning|nmod|END_ENTITY	cDNA cloning of MCT1 , a monocarboxylate transporter from rat skeletal muscle .
7829520	0	monocarboxylate	31,46	MCT1	93,97	monocarboxylate	MCT1	CHEBI:35757	6566	Chemical	Gene	transporter|compound|START_ENTITY MCT2|appos|transporter cloning|nmod|MCT2 expressed|nsubj|cloning expressed|nmod|END_ENTITY	cDNA cloning of MCT2 , a second monocarboxylate transporter expressed in different cells than MCT1 .
8603082	0	monocarboxylate	30,45	MCT1	122,126	monocarboxylate	MCT1	CHEBI:35757	17236(Tax:10090)	Chemical	Gene	transporter|amod|START_ENTITY Cloning|nmod|transporter confirms|csubj|Cloning confirms|nmod|END_ENTITY	Cloning and sequencing of the monocarboxylate transporter from mouse Ehrlich Lettr tumour cell confirms its identity as MCT1 and demonstrates that glycosylation is not required for MCT1 function .
9252498	0	monocarboxylate	14,29	MCT1	42,46	monocarboxylate	MCT1	CHEBI:35757	25027(Tax:10116)	Chemical	Gene	transporter|amod|START_ENTITY Expression|nmod|transporter END_ENTITY|nsubj|Expression	Expression of monocarboxylate transporter MCT1 by brain endothelium and glia in adult and suckling rats .
11973431	0	monocarboxylate	25,40	MCT2	0,4	monocarboxylate	MCT2	CHEBI:35757	20503(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|nsubj|END_ENTITY	MCT2 is a major neuronal monocarboxylate transporter in the adult mouse brain .
14622911	0	monocarboxylate	38,53	MCT2	67,71	monocarboxylate	MCT2	CHEBI:35757	29735(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY transporters|nsubj|expression transporters|dobj|END_ENTITY	Highly differential expression of the monocarboxylate transporters MCT2 and MCT4 in the developing rat brain .
15917240	0	monocarboxylate	64,79	MCT2	152,156	monocarboxylate	MCT2	CHEBI:35757	29735(Tax:10116)	Chemical	Gene	transporter|amod|START_ENTITY inhibition|nmod|transporter target|nmod|inhibition target|parataxis|EMBIGIN EMBIGIN|nsubj|protein protein|nmod|END_ENTITY	Basigin -LRB- CD147 -RRB- is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4 : the ancillary protein for the insensitive MCT2 is EMBIGIN -LRB- gp70 -RRB- .
7829520	0	monocarboxylate	31,46	MCT2	16,20	monocarboxylate	MCT2	CHEBI:35757	9194	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|appos|transporter	cDNA cloning of MCT2 , a second monocarboxylate transporter expressed in different cells than MCT1 .
9482213	0	monocarboxylate	18,33	MCT2	46,50	monocarboxylate	MCT2	CHEBI:35757	29735(Tax:10116)	Chemical	Gene	transporter|amod|START_ENTITY Expression|nmod|transporter END_ENTITY|nsubj|Expression	Expression of the monocarboxylate transporter MCT2 by rat brain glia .
21484790	0	monocarboxylate	85,100	MCT4	114,118	monocarboxylate	MCT4	CHEBI:35757	80879(Tax:10090)	Chemical	Gene	transporter|amod|START_ENTITY role|nmod|transporter pH|dep|role designed|nmod|pH designed|nsubj|END_ENTITY	In vivo pH in metabolic-defective Ras-transformed fibroblast tumors : key role of the monocarboxylate transporter , MCT4 , for inducing an alkaline intracellular pH. We present an investigation of tumor pH regulation , designed to support a new anticancer therapy concept that we had previously proposed .
22350013	0	monocarboxylate	23,38	MCT4	51,55	monocarboxylate	MCT4	CHEBI:35757	9123	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Butyrate activates the monocarboxylate transporter MCT4 expression in breast_cancer cells and enhances the antitumor activity of 3-bromopyruvate .
21646425	0	monocarboxylate	77,92	Mct1	108,112	monocarboxylate	Mct1	CHEBI:35757	6566	Chemical	Gene	transporter|amod|START_ENTITY silencing|nmod|transporter contribute|nmod|silencing contribute|nsubj|1 1|appos|END_ENTITY	miR-29a and miR-29b contribute to pancreatic beta-cell-specific silencing of monocarboxylate transporter 1 -LRB- Mct1 -RRB- .
17591909	0	monocarboxylate	33,48	SLC5A8	69,75	monocarboxylate	SLC5A8	CHEBI:35757	160728	Chemical	Gene	Expression|nmod|START_ENTITY transporters|nsubj|Expression transporters|dobj|SMCT1 SMCT1|appos|END_ENTITY	Expression of the sodium-coupled monocarboxylate transporters SMCT1 -LRB- SLC5A8 -RRB- and SMCT2 -LRB- SLC5A12 -RRB- in retina .
20211600	0	monocarboxylate	84,99	SLC5A8	74,80	monocarboxylate	SLC5A8	CHEBI:35757	160728	Chemical	Gene	transporter|amod|START_ENTITY END_ENTITY|appos|transporter	Sodium-coupled electrogenic transport of pyroglutamate -LRB- 5-oxoproline -RRB- via SLC5A8 , a monocarboxylate transporter .
16670197	0	monocarboxylate	6,21	SMCT	33,37	monocarboxylate	SMCT	CHEBI:35757	160728	Chemical	Gene	correlates|amod|START_ENTITY correlates|appos|END_ENTITY	Na -LRB- + -RRB- / monocarboxylate transport -LRB- SMCT -RRB- protein expression correlates with survival in colon_cancer : molecular characterization of SMCT .
17526579	0	monocarboxylate	52,67	SMCT1	82,87	monocarboxylate	SMCT1	CHEBI:35757	160728	Chemical	Gene	cotransporter|amod|START_ENTITY cotransporter|acl|END_ENTITY	Establishing a definitive stoichiometry for the Na + / monocarboxylate cotransporter SMCT1 .
17591909	0	monocarboxylate	33,48	SMCT1	62,67	monocarboxylate	SMCT1	CHEBI:35757	160728	Chemical	Gene	Expression|nmod|START_ENTITY transporters|nsubj|Expression transporters|dobj|END_ENTITY	Expression of the sodium-coupled monocarboxylate transporters SMCT1 -LRB- SLC5A8 -RRB- and SMCT2 -LRB- SLC5A12 -RRB- in retina .
15691871	0	monocarboxylate	75,90	USF1	8,12	monocarboxylate	USF1	CHEBI:35757	7391	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of USF1 and USF2 as potential repressor proteins for human intestinal monocarboxylate transporter 1 promoter .
17099289	0	monocarboxylate	23,38	slc5a8	138,144	monocarboxylate	slc5a8	CHEBI:35757	160728	Chemical	Gene	transporters|amod|START_ENTITY expression|nmod|transporters expression|nmod|tract tract|nmod|rat rat|nmod|reference reference|nmod|END_ENTITY	Cellular expression of monocarboxylate transporters -LRB- MCT -RRB- in the digestive tract of the mouse , rat , and humans , with special reference to slc5a8 .
20834181	0	monocarboxylates	80,96	SMCT2	27,32	monocarboxylates	SMCT2	CHEBI:35757	241612(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	The cellular expression of SMCT2 and its comparison with other transporters for monocarboxylates in the mouse digestive tract .
1532714	0	monocarboxylic	11,25	ATPase	59,65	monocarboxylic	ATPase	null	1769	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|amod|END_ENTITY	Effects of monocarboxylic and dicarboxylic_acids on myosin ATPase activity tested by luminometric procedure .
9563070	0	monocarboxylic_acid	55,74	AE2	33,36	monocarboxylic acid	AE2	CHEBI:25384	6522	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	Possible role of anion exchanger AE2 as the intestinal monocarboxylic_acid / anion antiporter .
10579682	0	monocarboxylic_acid	119,138	MCT1	151,155	monocarboxylic acid	MCT1	CHEBI:25384	25027(Tax:10116)	Chemical	Gene	transporter|amod|START_ENTITY acids|nmod|transporter absorption|nmod|acids characterization|nmod|absorption END_ENTITY|nsubj|characterization	Immunohistochemical and functional characterization of pH-dependent intestinal absorption of weak organic acids by the monocarboxylic_acid transporter MCT1 .
20227948	0	monochlorobiphenyls	14,33	cytochrome_P-450	56,72	monochlorobiphenyls	cytochrome P-450	null	25251(Tax:10116)	Chemical	Gene	Metabolism|nmod|START_ENTITY Metabolism|nmod|END_ENTITY	Metabolism of monochlorobiphenyls by hepatic microsomal cytochrome_P-450 .
10984130	0	monochlorodimedone	28,46	myeloperoxidase	50,65	monochlorodimedone	myeloperoxidase	MESH:C006991	4353	Chemical	Gene	Kinetics|nmod|START_ENTITY Kinetics|nmod|END_ENTITY	Kinetics of chlorination of monochlorodimedone by myeloperoxidase .
17071725	0	monocrotaline	70,83	eNOS	38,42	monocrotaline	eNOS	MESH:D016686	24600(Tax:10116)	Chemical	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	Aberrant cytoplasmic sequestration of eNOS in endothelial cells after monocrotaline , hypoxia , and senescence : live-cell caveolar and cytoplasmic NO imaging .
3123799	0	monocrotaline	101,114	elastin	8,15	monocrotaline	elastin	MESH:D016686	25043(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|END_ENTITY	Altered elastin and collagen synthesis associated with progressive_pulmonary_hypertension induced by monocrotaline .
26638897	0	monocrotaline	77,90	heparanase	28,38	monocrotaline	heparanase	MESH:D016686	64537(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|expression expression|nmod|END_ENTITY	Aberrant gene expression of heparanase in ventricular_hypertrophy induced by monocrotaline in rats .
8378355	0	monocyclic_beta-lactam	104,126	leukocyte_elastase	164,182	monocyclic beta-lactam	leukocyte elastase	null	1991	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|nmod|END_ENTITY	Chemical , biochemical , pharmacokinetic , and biological properties of L-680 ,833 : a potent , orally active monocyclic_beta-lactam inhibitor of human polymorphonuclear leukocyte_elastase .
3241180	0	monofluorofumarate	19,37	adenylosuccinate_lyase	43,65	monofluorofumarate	adenylosuccinate lyase	MESH:C034062	158	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	The interaction of monofluorofumarate with adenylosuccinate_lyase .
6615795	0	monofluorofumarate	61,79	argininosuccinate_lyase	34,57	monofluorofumarate	argininosuccinate lyase	MESH:C034062	512771(Tax:9913)	Chemical	Gene	inactivation|nmod|START_ENTITY inactivation|nmod|END_ENTITY	Substrate-induced inactivation of argininosuccinate_lyase by monofluorofumarate and difluorofumarate .
6692368	0	monofluoromethylhistidine	86,111	histidine_decarboxylase	159,182	monofluoromethylhistidine	histidine decarboxylase	null	15186(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Involvement of histamine in growth of mouse and rat tumors : antitumoral properties of monofluoromethylhistidine , an enzyme-activated irreversible inhibitor of histidine_decarboxylase .
2386795	0	monohydroperoxides	27,45	pancreatic_lipase	93,110	monohydroperoxides	pancreatic lipase	null	5406	Chemical	Gene	hydrolysis|nmod|START_ENTITY hydrolysis|nmod|END_ENTITY	Preferential hydrolysis of monohydroperoxides of linoleoyl and linolenoyl_triacylglycerol by pancreatic_lipase .
16310365	0	monomethyl_ester	81,97	Mg-protoporphyrin_IX	60,80	monomethyl ester	Mg-protoporphyrin IX	null	548287(Tax:4513)	Chemical	Gene	mutants|compound|START_ENTITY mutants|amod|END_ENTITY	Analysis of gun phenotype in barley magnesium chelatase and Mg-protoporphyrin_IX monomethyl_ester cyclase mutants .
22072423	0	monomethylfumarate	99,117	proton-coupled_folate_transporter	14,47	monomethylfumarate	proton-coupled folate transporter	MESH:C073341	52466(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of proton-coupled_folate_transporter in retinal M ller cells by the antipsoriatic drug monomethylfumarate .
18822201	0	mononucleotide	78,92	HLA-DRB1	61,69	mononucleotide	HLA-DRB1	CHEBI:29075	3123	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- The relationship between alpha-IFN anti-virus treatment and HLA-DRB1 * 11 gene mononucleotide polymorphism -RSB- .
19558492	0	mononucleotides	38,53	Sa2	19,22	mononucleotides	Sa2	CHEBI:29075	10735	Chemical	Gene	complexes|nmod|START_ENTITY complexes|amod|END_ENTITY	Structure of RNase Sa2 complexes with mononucleotides -- new aspects of catalytic reaction and substrate recognition .
1034936	0	monoolein	11,20	lipoprotein_lipase	54,72	monoolein	lipoprotein lipase	MESH:C005953	280843(Tax:9913)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of monoolein on hydrolysis of triglyceride by lipoprotein_lipase in the presence of an inhibitory apolipoprotein .
6250140	0	monophosphate	28,41	insulin	45,52	monophosphate	insulin	null	483665(Tax:9615)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	-LSB- Effect of adenosine cyclic monophosphate on insulin secretion in healthy rats and in those with alloxan_diabetes -RSB- .
23322736	0	monophosphoryl_lipid_A	60,82	Toll-like_receptor_4	0,20	monophosphoryl lipid A	Toll-like receptor 4	MESH:C048436	7099	Chemical	Gene	stimulation|nmod|START_ENTITY stimulation|amod|END_ENTITY	Toll-like_receptor_4 stimulation with the detoxified ligand monophosphoryl_lipid_A improves Alzheimer 's _ disease-related pathology .
11860734	0	monophosphoryl_lipid_A	71,93	heme_oxygenase-1	15,31	monophosphoryl lipid A	heme oxygenase-1	MESH:C048436	24451(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of heme_oxygenase-1 in delayed cardioprotection induced by monophosphoryl_lipid_A in rats .
19379773	0	monophosphoryl_lipid_A	135,157	hemoglobin_gamma-chain	207,229	monophosphoryl lipid A	hemoglobin gamma-chain	MESH:C048436	101106199	Chemical	Gene	signaling|nmod|START_ENTITY signaling|nmod|END_ENTITY	Induction of tolerogenic vs immunogenic dendritic cells -LRB- DCs -RRB- in the presence of GM-CSF is regulated by the strength of signaling from monophosphoryl_lipid_A -LRB- MPLA -RRB- in association with glutathione and fetal hemoglobin_gamma-chain .
9825227	0	monophosphoryl_lipid_A	37,59	iNOS	13,17	monophosphoryl lipid A	iNOS	MESH:C048436	24599(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Induction of iNOS gene expression by monophosphoryl_lipid_A : a pharmacological approach for myocardial_adaptation to ischemia .
12970485	0	monosaccharide	83,97	AtSTP9	76,82	monosaccharide	AtSTP9	CHEBI:35381	841453(Tax:3702)	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	Functional characterization and expression analyses of the glucose-specific AtSTP9 monosaccharide transporter in pollen of Arabidopsis .
1220990	0	monosaccharide	33,47	secretin	10,18	monosaccharide	secretin	CHEBI:35381	24769(Tax:10116)	Chemical	Gene	absorption|compound|START_ENTITY Effect|nmod|absorption Effect|nmod|END_ENTITY	Effect of secretin on intestinal monosaccharide absorption and new water movement in the rat .
7031247	0	monosaccharides	31,46	acrosin	20,27	monosaccharides	acrosin	MESH:D009005	49	Chemical	Gene	compounds|amod|START_ENTITY END_ENTITY|nmod|compounds	Inhibition of human acrosin by monosaccharides and related compounds : structure-activity relationships .
15950499	0	monosaccharides	66,81	delta-aminolevulinate_dehydratase	18,51	monosaccharides	delta-aminolevulinate dehydratase	MESH:D009005	210	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Human erythrocyte delta-aminolevulinate_dehydratase inhibition by monosaccharides is not mediated by oxidation of enzyme sulfhydryl groups .
8395948	0	monosialoganglioside	174,194	CA1	204,207	monosialoganglioside	CA1	null	310218(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|neurons neurons|nummod|END_ENTITY	Modulation of high-threshold Ca current and spontaneous postsynaptic transient currents by phorbol_12 ,13 - diacetate , 1 - -LRB- 5-isoquinolinesulfonyl -RRB- -2 - methyl_piperazine -LRB- H-7 -RRB- , and monosialoganglioside -LRB- GM1 -RRB- in CA1 pyramidal neurons of rat hippocampus in vitro .
1695953	0	monosialoganglioside	10,30	GM1	32,35	monosialoganglioside	GM1	null	210582(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of monosialoganglioside -LRB- GM1 -RRB- on transected monoaminergic pathways .
2713652	0	monosialoganglioside	48,68	nerve_growth_factor	20,39	monosialoganglioside	nerve growth factor	null	310738(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Interaction Interaction|nmod|END_ENTITY	Interaction between nerve_growth_factor and GM1 monosialoganglioside in preventing cortical choline acetyltransferase and high affinity choline uptake decrease after lesion of the nucleus basalis .
2478163	0	monosialoganglioside_GM1	62,86	CD4	0,3	monosialoganglioside GM1	CD4	CHEBI:61048	920	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|END_ENTITY	CD4 modulation and inhibition_of_HIV-1_infectivity induced by monosialoganglioside_GM1 in vitro .
6833931	0	monosodium-L-glutamate	48,70	growth_hormone	74,88	monosodium-L-glutamate	growth hormone	CHEBI:64243	81668(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	Effects of naloxone and neonatal treatment with monosodium-L-glutamate on growth_hormone and prolactin release induced by electrical stimulation of the medial-basal hypothalamus in rats .
15531098	0	monosodium-glutamate	97,117	pituitary_adenylate_cyclase_activating_polypeptide	11,61	monosodium-glutamate	pituitary adenylate cyclase activating polypeptide	CHEBI:64243	24166(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Effects Effects|nmod|END_ENTITY	Effects of pituitary_adenylate_cyclase_activating_polypeptide in retinal_degeneration induced by monosodium-glutamate .
2995533	0	monosodium_L-glutamate	115,137	LHRH	74,78	monosodium L-glutamate	LHRH	CHEBI:64243	25194(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY END_ENTITY|nmod|treatment	Pituitary receptors for LH-releasing_hormone -LRB- LHRH -RRB- and responsiveness to LHRH in adult female rats after neonatal monosodium_L-glutamate treatment .
26900785	0	monosodium_glutamate	107,127	Bcl-2	44,49	monosodium glutamate	Bcl-2	CHEBI:64243	24224(Tax:10116)	Chemical	Gene	transcripts|nmod|START_ENTITY transcripts|amod|END_ENTITY	Lycopene modulates cholinergic dysfunction , Bcl-2 / Bax balance , and antioxidant enzymes gene transcripts in monosodium_glutamate -LRB- E621 -RRB- induced neurotoxicity in a rat model .
23620336	0	monosodium_glutamate	36,56	CB1	11,14	monosodium glutamate	CB1	CHEBI:64243	25248(Tax:10116)	Chemical	Gene	blockade|nmod|START_ENTITY blockade|compound|END_ENTITY	Effects of CB1 receptor blockade on monosodium_glutamate induced hypometabolic and hypothalamic_obesity in rats .
20153005	0	monosodium_glutamate	63,83	Dipeptidyl_peptidase_IV	0,23	monosodium glutamate	Dipeptidyl peptidase IV	CHEBI:64243	25253(Tax:10116)	Chemical	Gene	rats|amod|START_ENTITY END_ENTITY|nmod|rats	Dipeptidyl_peptidase_IV in the hypothalamus and hippocampus of monosodium_glutamate obese and food-deprived rats .
3085872	0	monosodium_glutamate	38,58	GH	85,87	monosodium glutamate	GH	CHEBI:64243	81668(Tax:10116)	Chemical	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Effects of neonatal administration of monosodium_glutamate on plasma growth_hormone -LRB- GH -RRB- response to GH-releasing_factor in adult male and female rats .
7476908	0	monosodium_glutamate	194,214	Growth_hormone	0,14	monosodium glutamate	Growth hormone	CHEBI:64243	81668(Tax:10116)	Chemical	Gene	rendered|nmod|START_ENTITY rendered|nsubj|regulation regulation|amod|END_ENTITY	Growth_hormone regulation of male-specific rat liver P450s 2A2 and 3A2 : induction by intermittent growth_hormone pulses in male but not female rats rendered growth_hormone deficient by neonatal monosodium_glutamate .
2322864	0	monosodium_glutamate	83,103	Neuropeptide_Y	0,14	monosodium glutamate	Neuropeptide Y	CHEBI:64243	24604(Tax:10116)	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|END_ENTITY	Neuropeptide_Y in the specific hypothalamic nuclei of rats treated neonatally with monosodium_glutamate .
1989848	0	monosodium_glutamate	24,44	growth_hormone	67,81	monosodium glutamate	growth hormone	CHEBI:64243	81668(Tax:10116)	Chemical	Gene	treatment|nmod|START_ENTITY treatment|dep|effects effects|nmod|END_ENTITY	Neonatal treatment with monosodium_glutamate : effects of prolonged growth_hormone -LRB- GH -RRB- - releasing hormone deficiency on pulsatile GH secretion and growth in female rats .
2106092	0	monosodium_glutamate	71,91	growth_hormone	151,165	monosodium glutamate	growth hormone	CHEBI:64243	81668(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY growth_hormone-releasing_hormone|nmod|treatment Depletion|nmod|growth_hormone-releasing_hormone reveals|nsubj|Depletion reveals|nmod|secretion secretion|amod|END_ENTITY	Depletion of hypothalamic growth_hormone-releasing_hormone by neonatal monosodium_glutamate treatment reveals an inhibitory effect of betamethasone on growth_hormone secretion in adult rats .
2298167	0	monosodium_glutamate	67,87	growth_hormone	19,33	monosodium glutamate	growth hormone	CHEBI:64243	81668(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY END_ENTITY|nmod|treatment	Depletion of serum growth_hormone in adult female rats by neonatal monosodium_glutamate treatment without loss of female-specific hepatic enzymes P450 2d -LRB- IIC12 -RRB- and steroid 5 alpha-reductase .
3085872	0	monosodium_glutamate	38,58	growth_hormone	69,83	monosodium glutamate	growth hormone	CHEBI:64243	81668(Tax:10116)	Chemical	Gene	response|amod|START_ENTITY response|compound|END_ENTITY	Effects of neonatal administration of monosodium_glutamate on plasma growth_hormone -LRB- GH -RRB- response to GH-releasing_factor in adult male and female rats .
3830732	0	monosodium_glutamate	131,151	growth_hormone	92,106	monosodium glutamate	growth hormone	CHEBI:64243	14599(Tax:10090)	Chemical	Gene	given|xcomp|START_ENTITY mice|acl|given level|nmod|mice level|amod|END_ENTITY	Suppression of normal and preneoplastic mammary growth and uterine adenomyosis with reduced growth_hormone level in SHN mice given monosodium_glutamate neonatally .
6320028	0	monosodium_glutamate	35,55	growth_hormone	59,73	monosodium glutamate	growth hormone	CHEBI:64243	81668(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|release release|amod|END_ENTITY	Effects of neonatal treatment with monosodium_glutamate on growth_hormone release induced by clonidine and prostaglandin_E1 in conscious male rats .
7476908	0	monosodium_glutamate	194,214	growth_hormone	157,171	monosodium glutamate	growth hormone	CHEBI:64243	81668(Tax:10116)	Chemical	Gene	rendered|nmod|START_ENTITY rendered|dobj|deficient deficient|amod|END_ENTITY	Growth_hormone regulation of male-specific rat liver P450s 2A2 and 3A2 : induction by intermittent growth_hormone pulses in male but not female rats rendered growth_hormone deficient by neonatal monosodium_glutamate .
7476908	0	monosodium_glutamate	194,214	growth_hormone	98,112	monosodium glutamate	growth hormone	CHEBI:64243	81668(Tax:10116)	Chemical	Gene	rendered|nmod|START_ENTITY rendered|nsubj|regulation regulation|nmod|liver liver|dep|induction induction|nmod|pulses pulses|compound|END_ENTITY	Growth_hormone regulation of male-specific rat liver P450s 2A2 and 3A2 : induction by intermittent growth_hormone pulses in male but not female rats rendered growth_hormone deficient by neonatal monosodium_glutamate .
7965769	0	monosodium_glutamate	204,224	growth_hormone	134,148	monosodium glutamate	growth hormone	CHEBI:64243	81668(Tax:10116)	Chemical	Gene	levels|nmod|START_ENTITY exposed|nmod|levels Over-expression|acl|exposed Over-expression|nmod|presence presence|nmod|pulses pulses|acl|circulating circulating|dobj|END_ENTITY	Over-expression of CYP2C11 , the major male-specific form of hepatic cytochrome P450 , in the presence of nominal pulses of circulating growth_hormone in adult male rats neonatally exposed to low levels of monosodium_glutamate .
8161351	0	monosodium_glutamate	35,55	growth_hormone	106,120	monosodium glutamate	growth hormone	CHEBI:64243	14599(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|profiles profiles|acl|circulating circulating|dobj|END_ENTITY	Effects of neonatally administered monosodium_glutamate on the sexually dimorphic profiles of circulating growth_hormone regulating murine hepatic monooxygenases .
10718930	0	monosodium_glutamate	140,160	growth_hormone-releasing_hormone	59,91	monosodium glutamate	growth hormone-releasing hormone	CHEBI:64243	29446(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY Increase|nmod|treatment Increase|nmod|concentrations concentrations|nmod|receptors receptors|nmod|secretagogues secretagogues|amod|END_ENTITY	Increase in mRNA concentrations of pituitary receptors for growth_hormone-releasing_hormone and growth_hormone secretagogues after neonatal monosodium_glutamate treatment .
2106092	0	monosodium_glutamate	71,91	growth_hormone-releasing_hormone	26,58	monosodium glutamate	growth hormone-releasing hormone	CHEBI:64243	29446(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY END_ENTITY|nmod|treatment	Depletion of hypothalamic growth_hormone-releasing_hormone by neonatal monosodium_glutamate treatment reveals an inhibitory effect of betamethasone on growth_hormone secretion in adult rats .
17307297	0	monosodium_glutamate	128,148	preprotachykinin_A	35,53	monosodium glutamate	preprotachykinin A	CHEBI:64243	21333(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|nmod|mRNA mRNA|compound|END_ENTITY	Temporal and spatial expression of preprotachykinin_A mRNA in the developing filial mice brain after maternal administration of monosodium_glutamate at a late stage of pregnancy .
1980722	0	monosodium_glutamate	76,96	tyrosine_hydroxylase	40,60	monosodium glutamate	tyrosine hydroxylase	CHEBI:64243	25085(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY END_ENTITY|nmod|treatment	Sex-related alterations in hypothalamic tyrosine_hydroxylase after neonatal monosodium_glutamate treatment .
11739559	0	monosodium_urate	54,70	IL-8	87,91	monosodium urate	IL-8	MESH:D014527	3576	Chemical	Gene	START_ENTITY|dobj|expression expression|compound|END_ENTITY	Src family protein tyrosine kinase signaling mediates monosodium_urate crystal-induced IL-8 expression by monocytic THP-1 cells .
22366735	0	monosodium_urate	101,117	vascular_cell_adhesion_molecule_1	134,167	monosodium urate	vascular cell adhesion molecule 1	MESH:D014527	7412	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Involvement of mitogen-activated protein kinases and peroxisome proliferator-activated receptor y in monosodium_urate crystal-induced vascular_cell_adhesion_molecule_1 expression in human rheumatoid_arthritis synovial fibroblasts .
3209	0	monoterpene	49,60	cytochrome_P-450	22,38	monoterpene	cytochrome P-450	CHEBI:35187	4051	Chemical	Gene	START_ENTITY|amod|dependent dependent|amod|END_ENTITY	Characterization of a cytochrome_P-450 dependent monoterpene hydroxylase from the higher plant Vinca rosea .
20832830	0	monoterpene	19,30	lipase	2,8	monoterpene	lipase	CHEBI:35187	16891(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|inhibitor inhibitor|amod|END_ENTITY	A lipase inhibitor monoterpene and monoterpene_glycosides from Monarda punctata .
22375890	0	monounsaturated_fatty_acids	38,65	visfatin	75,83	monounsaturated fatty acids	visfatin	MESH:D005229	10135	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Effect of substituting saturated with monounsaturated_fatty_acids on serum visfatin levels and insulin resistance in overweight women : a randomized cross-over clinical trial .
19443194	0	monounsaturated_nor_saturated_fatty_acids	136,177	NPC1L1	115,121	monounsaturated nor saturated fatty acids	NPC1L1	null	29881	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|dep|effect	Polyunsaturated_fatty_acids down-regulate in vitro expression of the key intestinal cholesterol absorption protein NPC1L1 : no effect of monounsaturated_nor_saturated_fatty_acids .
17027749	0	montelukast	40,51	Adenosine_A1_receptor	0,21	montelukast	Adenosine A1 receptor	MESH:C093875	100328615(Tax:9986)	Chemical	Gene	antagonist|nmod|START_ENTITY antagonist|amod|END_ENTITY	Adenosine_A1_receptor antagonist versus montelukast on airway reactivity and inflammation .
10471986	0	montelukast	28,39	CysLT1	43,49	montelukast	CysLT1	MESH:C093875	10800	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Effect of multiple doses of montelukast , a CysLT1 receptor antagonist , on digoxin pharmacokinetics in healthy volunteers .
17173892	0	montelukast	64,75	CysLT1	101,107	montelukast	CysLT1	MESH:C093875	114099(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Oxidative renal damage in pyelonephritic rats is ameliorated by montelukast , a selective leukotriene CysLT1 receptor antagonist .
19309765	0	montelukast	18,29	CysLT1	75,81	montelukast	CysLT1	MESH:C093875	10800	Chemical	Gene	Quantification|nmod|START_ENTITY antagonist|nsubj|Quantification antagonist|nsubj|receptor receptor|appos|END_ENTITY	Quantification of montelukast , a selective cysteinyl_leukotriene receptor -LRB- CysLT1 -RRB- antagonist in human plasma by liquid chromatography-mass spectrometry : validation and its application to a human pharmacokinetic study .
10051701	0	montelukast	14,25	MK-0476	27,34	montelukast	MK-0476	MESH:C093875	1477779(Tax:190192)	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of montelukast -LRB- MK-0476 -RRB- , a cysteinyl_leukotriene receptor antagonist , on allergen-induced airway responses and sputum cell counts in asthma .
11586212	0	montelukast	49,60	cysteinyl_leukotriene_D4_receptor	4,37	montelukast	cysteinyl leukotriene D4 receptor	MESH:C093875	10800	Chemical	Gene	START_ENTITY|nsubj|antagonist antagonist|amod|END_ENTITY	The cysteinyl_leukotriene_D4_receptor antagonist montelukast for the treatment of interstitial_cystitis .
24494466	0	montelukast	21,32	cysteinyl_leukotriene_receptor-1	36,68	montelukast	cysteinyl leukotriene receptor-1	MESH:C093875	114099(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Protective effect of montelukast , a cysteinyl_leukotriene_receptor-1 antagonist , against intestinal_ischemia-reperfusion injury in the rat .
15608135	0	montelukast	52,63	cytochrome_P4502C8	30,48	montelukast	cytochrome P4502C8	MESH:C093875	1558	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Selective inhibition of human cytochrome_P4502C8 by montelukast .
15725194	0	montelukast	29,40	interleukin-10	53,67	montelukast	interleukin-10	MESH:C093875	3586	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|production production|amod|END_ENTITY	The effect of treatment with montelukast on in vitro interleukin-10 production of mononuclear cells of children with asthma .
20112601	0	montelukast	29,40	interleukin-10	60,74	montelukast	interleukin-10	MESH:C093875	3586	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|levels levels|nmod|END_ENTITY	The effect of treatment with montelukast on levels of serum interleukin-10 , eosinophil_cationic_protein , blood eosinophil counts , and clinical parameters in children with asthma .
24126112	0	montelukast	11,22	ovalbumin	84,93	montelukast	ovalbumin	MESH:C093875	282665(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of montelukast on subepithelial/peribronchial fibrosis in a murine model of ovalbumin induced chronic_asthma .
8692739	0	montelukast_sodium	49,67	MK-0476	69,76	montelukast sodium	MK-0476	MESH:C093875	1477779(Tax:190192)	Chemical	Gene	Pharmacokinetics|nmod|START_ENTITY Pharmacokinetics|appos|END_ENTITY	Pharmacokinetics , bioavailability , and safety of montelukast_sodium -LRB- MK-0476 -RRB- in healthy males and females .
9429741	0	montelukast_sodium	40,58	MK-0476	60,67	montelukast sodium	MK-0476	MESH:C093875	1477779(Tax:190192)	Chemical	Gene	Pharmacokinetics|nmod|START_ENTITY Pharmacokinetics|appos|END_ENTITY	Pharmacokinetics and bioavailability of montelukast_sodium -LRB- MK-0476 -RRB- in healthy young and elderly volunteers .
8827723	0	montirelin_hydrate	40,58	NS-3	60,64	montirelin hydrate	NS-3	MESH:C031926	25263(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	-LSB- EEG studies on the analeptic effect of montirelin_hydrate -LRB- NS-3 -RRB- , a TRH analog , in posterior_hypothalamic_area-lesioned rats -RSB- .
3522680	0	morantel_tartrate	12,29	milk	33,37	morantel tartrate	milk	MESH:D009015	100532204	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Efficacy of morantel_tartrate on milk production of dairy cows : a field study .
26513344	0	morin	35,40	PHLPP2	15,21	morin	PHLPP2	MESH:C008548	498949(Tax:10116)	Chemical	Gene	induction|nmod|START_ENTITY induction|nummod|END_ENTITY	Suppression in PHLPP2 induction by morin promotes Nrf2-regulated cellular defenses against oxidative injury to primary rat hepatocytes .
18812655	0	morphine	45,53	5-HTT	77,82	morphine	5-HTT	MESH:D009020	25553(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Association of different susceptibilities to morphine with the expression of 5-HTT and 5-HT1AR mRNA in brain regions of SD rats .
3986069	0	morphine	35,43	ADH	47,50	morphine	ADH	MESH:D009020	551	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Effect of postoperative extradural morphine on ADH secretion .
18973795	0	morphine	33,41	Aquaporin_4	0,11	morphine	Aquaporin 4	MESH:D009020	11829(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|modulates modulates|amod|END_ENTITY	Aquaporin_4 deficiency modulates morphine pharmacological actions .
12113961	0	morphine	32,40	CB1	56,59	morphine	CB1	MESH:D009020	12801(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|compound|END_ENTITY	Conditioned place preference to morphine in cannabinoid CB1 receptor knockout mice .
21373789	0	morphine	11,19	CB1	69,72	morphine	CB1	MESH:D009020	12801(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|knockout knockout|compound|END_ENTITY	Effects of morphine on pain-elicited_and_pain-suppressed behavior in CB1 knockout and wildtype mice .
12151554	10	morphine	1473,1481	CGRP	1564,1568	morphine	CGRP	MESH:D009020	24241(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Sustained morphine induces plasticity in both primary afferents and spinal cord , including increased CGRP and dynorphin content .
18328477	0	morphine	10,18	CGRP	44,48	morphine	CGRP	MESH:D009020	24241(Tax:10116)	Chemical	Gene	augments|amod|START_ENTITY END_ENTITY|nsubj|augments	Sustained morphine treatment augments basal CGRP release from cultured primary sensory neurons in a Raf-1 dependent manner .
16301642	0	morphine	35,43	CYP2D6	45,51	morphine	CYP2D6	MESH:D009020	1565	Chemical	Gene	synthesize|xcomp|START_ENTITY synthesize|dep|modulation modulation|nummod|END_ENTITY	Human white blood cells synthesize morphine : CYP2D6 modulation .
17573783	0	morphine	11,19	CYP2D6	75,81	morphine	CYP2D6	MESH:D009020	1565	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Endogenous morphine signaling via nitric_oxide regulates the expression of CYP2D6 and COMT : autocrine/paracrine feedback inhibition .
18971888	0	morphine	24,32	CYP2D6	0,6	morphine	CYP2D6	MESH:D009020	1565	Chemical	Gene	synthesis|amod|START_ENTITY enzyme|nmod|synthesis END_ENTITY|dep|enzyme	CYP2D6 : a key enzyme in morphine synthesis in animals .
19523031	0	morphine	60,68	CYP2D6	14,20	morphine	CYP2D6	MESH:D009020	1565	Chemical	Gene	consumption|compound|START_ENTITY impact|nmod|consumption impact|nmod|polymorphisms polymorphisms|nummod|END_ENTITY	The impact of CYP2D6 genetic polymorphisms on postoperative morphine consumption .
22641033	0	morphine	79,87	CYP2D6	58,64	morphine	CYP2D6	MESH:D009020	1565	Chemical	Gene	formation|compound|START_ENTITY END_ENTITY|nmod|formation	Rat CYP2D2 , not 2D1 , is functionally conserved with human CYP2D6 in endogenous morphine formation .
8823235	0	morphine	13,21	CYP2D6	68,74	morphine	CYP2D6	MESH:D009020	1565	Chemical	Gene	Formation|nmod|START_ENTITY Formation|nmod|subjects subjects|nmod|genotypes genotypes|compound|END_ENTITY	Formation of morphine from codeine in Chinese subjects of different CYP2D6 genotypes .
2177898	0	morphine	11,19	Ca2	55,58	morphine	Ca2	MESH:D009020	54231(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of morphine on arachidonic_acid metabolism , on Ca2 -LRB- + -RRB- - uptake and on cAMP synthesis in uterine strips from spayed rats .
2963216	0	morphine	11,19	Ca2	39,42	morphine	Ca2	MESH:D009020	760	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|+ +|amod|END_ENTITY	Effects of morphine and B-endorphin on Ca2 + - ATPase activity of synaptic plasma membranes .
24490859	0	morphine	132,140	Corticotropin-releasing_factor	0,30	morphine	Corticotropin-releasing factor	MESH:D009020	12918(Tax:10090)	Chemical	Gene	withdrawal|compound|START_ENTITY observed|nmod|withdrawal activity|acl|observed involved|nmod|activity involved|nsubjpass|receptor-1 receptor-1|amod|END_ENTITY	Corticotropin-releasing_factor -LRB- CRF -RRB- receptor-1 is involved in cardiac noradrenergic activity observed during naloxone-precipitated morphine withdrawal .
12373690	0	morphine	40,48	Cyclooxygenase-2	0,16	morphine	Cyclooxygenase-2	MESH:D009020	29527(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|potentiates potentiates|amod|END_ENTITY	Cyclooxygenase-2 inhibition potentiates morphine antinociception at the spinal level in a postoperative_pain model .
11383718	0	morphine	47,55	D1_receptor	59,70	morphine	D1 receptor	MESH:D009020	13488(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Loss_of_locomotor_sensitisation in response to morphine in D1_receptor deficient mice .
23037317	0	morphine	78,86	ERK1/2	90,96	morphine	ERK1/2	MESH:D009020	50689;116590	Chemical	Gene	START_ENTITY|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Thermal stimulation of primary sensory neurons in the rat hind paw : effect of morphine on ERK1/2 phosphorylation , TRPV1 and TRPA1 channel expression .
460727	0	morphine	57,65	Enkephalin	0,10	morphine	Enkephalin	MESH:D009020	29237(Tax:10116)	Chemical	Gene	administration|amod|START_ENTITY levels|nmod|administration levels|compound|END_ENTITY	Enkephalin levels in rat brain after various regimens of morphine administration .
563332	0	morphine	56,64	Enkephalin	0,10	morphine	Enkephalin	MESH:D009020	29237(Tax:10116)	Chemical	Gene	dependent|amod|START_ENTITY rats|amod|dependent assay|nmod|rats END_ENTITY|dep|assay	Enkephalin : radioimmunoassay and radioreceptor assay in morphine dependent rats .
575096	0	morphine	50,58	Enkephalin	0,10	morphine	Enkephalin	MESH:D009020	29237(Tax:10116)	Chemical	Gene	abstinence|amod|START_ENTITY decrease|nmod|abstinence decrease|nsubj|levels levels|compound|END_ENTITY	Enkephalin levels decrease in rat striatum during morphine abstinence .
23143893	0	morphine	101,109	Extracellular_signal-regulated_kinase_5	0,39	morphine	Extracellular signal-regulated kinase 5	MESH:D009020	114509(Tax:10116)	Chemical	Gene	contributes|xcomp|START_ENTITY contributes|nsubj|END_ENTITY	Extracellular_signal-regulated_kinase_5 in the cerebrospinal fluid-contacting nucleus contributes to morphine physical_dependence in rats .
7668153	0	morphine	23,31	FOS	97,100	morphine	FOS	MESH:D009020	314322(Tax:10116)	Chemical	Gene	treatment|nmod|START_ENTITY attenuates|nsubj|treatment attenuates|dobj|activation activation|nmod|expression expression|compound|END_ENTITY	Chronic treatment with morphine and ethanol , but not cocaine , attenuates IL-1_beta activation of FOS expression in the rat hypothalamic paraventricular nucleus .
8930328	0	morphine	129,137	FOS	0,3	morphine	FOS	MESH:D009020	314322(Tax:10116)	Chemical	Gene	attenuated|xcomp|START_ENTITY attenuated|nsubjpass|expression expression|compound|END_ENTITY	FOS expression induced by interleukin-1 or acute morphine treatment in the rat hypothalamus is attenuated by chronic exposure to morphine .
8930328	0	morphine	49,57	FOS	0,3	morphine	FOS	MESH:D009020	314322(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY induced|nmod|treatment expression|acl|induced expression|compound|END_ENTITY	FOS expression induced by interleukin-1 or acute morphine treatment in the rat hypothalamus is attenuated by chronic exposure to morphine .
10082860	0	morphine	11,19	Fos	43,46	morphine	Fos	MESH:D009020	314322(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|distribution distribution|nmod|END_ENTITY	Effects of morphine on the distribution of Fos protein in the trigeminal subnucleus caudalis neurons during experimental tooth movement of the rat molar .
10773195	6	morphine	1234,1242	Fos	1264,1267	morphine	Fos	MESH:D009020	314322(Tax:10116)	Chemical	Gene	site|amod|START_ENTITY site|appos|plume plume|compound|END_ENTITY	The plume-shaped region of drug-induced increase in Fos immunoreactivity immediately surrounding a morphine microinjection site -LRB- Fos plume -RRB- was objectively mapped .
11376912	0	morphine	12,20	Fos	102,105	morphine	Fos	MESH:D009020	314322(Tax:10116)	Chemical	Gene	modify|advmod|START_ENTITY modify|nmod|rat rat|dep|study study|compound|END_ENTITY	Intravenous morphine does not modify dorsal horn touch-evoked allodynia in the mononeuropathic rat : a Fos study .
11747755	0	morphine	91,99	Fos	24,27	morphine	Fos	MESH:D009020	314322(Tax:10116)	Chemical	Gene	withdrawal|amod|START_ENTITY expression|nmod|withdrawal expression|nsubj|increase increase|nmod|protein protein|compound|END_ENTITY	NO mediated increase of Fos protein and NMDA1A R mRNA expression in rat spinal cord during morphine withdrawal .
12589382	0	morphine	9,17	Fos	88,91	morphine	Fos	MESH:D009020	314322(Tax:10116)	Chemical	Gene	preference|compound|START_ENTITY preference|dep|association association|nmod|expression expression|compound|END_ENTITY	Enhanced morphine preference following prolonged abstinence : association with increased Fos expression in the extended amygdala .
15663473	0	morphine	148,156	Fos	94,97	morphine	Fos	MESH:D009020	314322(Tax:10116)	Chemical	Gene	withdrawal|amod|START_ENTITY expression|nmod|withdrawal expression|compound|END_ENTITY	Involvement of 3 ' ,5 ' - cyclic_adenosine_monophosphate-dependent protein kinase in regulation of Fos expression and tyrosine_hydroxylase levels during morphine withdrawal in the hypothalamic paraventricular nucleus and medulla oblongata catecholaminergic cell groups .
16474935	0	morphine	74,82	Fos	29,32	morphine	Fos	MESH:D009020	2353	Chemical	Gene	withdrawal|amod|START_ENTITY induced|dobj|withdrawal naloxone|acl|induced expression|nmod|naloxone expression|nsubj|Role Role|nmod|PKC PKC|nmod|regulation regulation|nmod|END_ENTITY	Role of PKC in regulation of Fos and TH expression after naloxone induced morphine withdrawal in the heart .
1688935	0	morphine	9,17	Fos	53,56	morphine	Fos	MESH:D009020	314322(Tax:10116)	Chemical	Gene	suppresses|compound|START_ENTITY noxious|nsubj|suppresses noxious|dobj|immunoreactivity immunoreactivity|compound|END_ENTITY	Systemic morphine suppresses noxious stimulus-evoked Fos protein-like immunoreactivity in the rat spinal cord .
18485622	0	morphine	130,138	Fos	71,74	morphine	Fos	MESH:D009020	314322(Tax:10116)	Chemical	Gene	modify|xcomp|START_ENTITY modify|dobj|expression expression|amod|END_ENTITY	Morphine and methadone pre-exposures differently modify brain regional Fos protein expression and locomotor activity responses to morphine challenge in the rat .
19481580	0	morphine	47,55	Fos	89,92	morphine	Fos	MESH:D009020	314322(Tax:10116)	Chemical	Gene	responses|amod|START_ENTITY responses|compound|END_ENTITY	Methadone is substantially less effective than morphine in modifying locomotor and brain Fos responses to subsequent methadone challenge in rats .
19705550	0	morphine	153,161	Fos	13,16	morphine	Fos	MESH:D009020	314322(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY behaviours|acl|induced correlates|nmod|behaviours correlates|nsubj|Induction Induction|nmod|proteins proteins|compound|END_ENTITY	Induction of Fos proteins in regions of the nucleus accumbens and ventrolateral striatum correlates with catalepsy and stereotypic behaviours induced by morphine .
19708041	0	morphine	35,43	Fos	9,12	morphine	Fos	MESH:D009020	314322(Tax:10116)	Chemical	Gene	withdrawal|amod|START_ENTITY induced|nmod|withdrawal induced|nsubj|expression expression|compound|END_ENTITY	Regional Fos expression induced by morphine withdrawal in the 7-day-old rat .
8152542	0	morphine	15,23	Fos	92,95	morphine	Fos	MESH:D009020	314322(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Application of morphine prior to noxious stimulation differentially modulates expression of Fos , Jun and Krox-24 proteins in rat spinal cord neurons .
20573450	0	morphine	51,59	Iba1	71,75	morphine	Iba1	MESH:D009020	29427(Tax:10116)	Chemical	Gene	tolerance|amod|START_ENTITY tolerance|appos|END_ENTITY	Inhibition of microglial P2X4 receptors attenuates morphine tolerance , Iba1 , GFAP and mu opioid receptor protein expression while enhancing perivascular microglial ED2 .
19818835	0	morphine	72,80	JNK	54,57	morphine	JNK	MESH:D009020	116554(Tax:10116)	Chemical	Gene	tolerance|amod|START_ENTITY activation|nmod|tolerance activation|compound|END_ENTITY	NMDA receptors are involved in upstream of the spinal JNK activation in morphine antinociceptive tolerance .
22491351	0	morphine	39,47	JNK	94,97	morphine	JNK	MESH:D009020	26419(Tax:10090)	Chemical	Gene	phenotypes|nmod|START_ENTITY due|nsubj|phenotypes due|nmod|unmasking unmasking|nmod|signaling signaling|compound|END_ENTITY	Evidence that behavioral phenotypes of morphine in b-arr2 - / - mice are due to the unmasking of JNK signaling .
25806604	0	morphine	83,91	JNK	14,17	morphine	JNK	MESH:D009020	5599	Chemical	Gene	hyperalgesia|amod|START_ENTITY contributes|nmod|hyperalgesia contributes|nsubj|Activation Activation|nmod|pathway pathway|compound|END_ENTITY	Activation of JNK pathway in spinal astrocytes contributes to acute ultra-low-dose morphine thermal hyperalgesia .
3075144	0	morphine	66,74	LH-RH	13,18	morphine	LH-RH	MESH:D009020	25194(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|END_ENTITY	Hypothalamic LH-RH release after acute and chronic treatment with morphine studied in a combined in vivo/in vitro model .
356791	0	morphine	26,34	LHRH	62,66	morphine	LHRH	MESH:D009020	25194(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY course|nmod|effects course|nmod|content content|nmod|END_ENTITY	Time course of effects of morphine on hypothalamic content of LHRH and serum testosterone and LH levels of morphine-tolerant and nontolerant male rats .
357165	0	morphine	10,18	LHRH	68,72	morphine	LHRH	MESH:D009020	2796	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of morphine on the basal and the dopamine-induced release of LHRH from mediobasal hypothalamic fragments in vitro .
16967907	0	morphine	24,32	Leu5	48,52	morphine	Leu5	MESH:D009020	10206	Chemical	Gene	dynamics|nmod|START_ENTITY dynamics|nmod|END_ENTITY	Vibrational dynamics of morphine in relation to Leu5 -- and Met5-enkephalins .
21657859	0	morphine	26,34	MIR	36,39	morphine	MIR	MESH:D009020	220972	Chemical	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of immediate-release morphine -LRB- MIR -RRB- in the treatment of predictable pain in radiotherapy .
11568638	0	morphine	60,68	MOR-1	40,45	morphine	MOR-1	MESH:D009020	18390(Tax:10090)	Chemical	Gene	Differential|nmod|START_ENTITY Differential|nmod|internalization internalization|nmod|END_ENTITY	Differential in vivo internalization of MOR-1 and MOR-1C by morphine .
19429175	0	morphine	39,47	MOR-1	20,25	morphine	MOR-1	MESH:D009020	18390(Tax:10090)	Chemical	Gene	analgesia|amod|START_ENTITY exons|nmod|analgesia exons|nsubj|contribution contribution|nmod|END_ENTITY	The contribution of MOR-1 exons 1-4 to morphine and heroin analgesia and dependence .
22089925	0	morphine	96,104	MOR-1	18,23	morphine	MOR-1	MESH:D009020	25601(Tax:10116)	Chemical	Gene	administration|nmod|START_ENTITY END_ENTITY|nmod|administration	Regulation of rat MOR-1 gene expression after chronic intracerebroventricular administration of morphine .
22992838	0	morphine	75,83	MOR-1	24,29	morphine	MOR-1	MESH:D009020	4988	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of mammalian MOR-1 gene expression after chronic treatment with morphine .
7583338	0	morphine	76,84	MOR-1	34,39	morphine	MOR-1	MESH:D009020	25601(Tax:10116)	Chemical	Gene	mRNA|nmod|START_ENTITY mRNA|nsubj|levels levels|appos|END_ENTITY	CNS levels of mu_opioid_receptor -LRB- MOR-1 -RRB- mRNA during chronic treatment with morphine or naltrexone .
8592651	0	morphine	25,33	MOR-1	128,133	morphine	MOR-1	MESH:D009020	25601(Tax:10116)	Chemical	Gene	analgesia|amod|START_ENTITY blockade|nmod|analgesia directed|nsubj|blockade directed|nmod|subunits subunits|amod|END_ENTITY	Differential blockade of morphine and morphine-6_beta-glucuronide analgesia by antisense oligodeoxynucleotides directed against MOR-1 and G-protein alpha subunits in rats .
9103486	0	morphine	59,67	MOR-1	21,26	morphine	MOR-1	MESH:D009020	25601(Tax:10116)	Chemical	Gene	antinociception|amod|START_ENTITY distinguishing|nmod|antinociception mapping|dep|distinguishing mapping|nmod|END_ENTITY	Antisense mapping of MOR-1 in rats : distinguishing between morphine and morphine-6beta-glucuronide antinociception .
10458517	0	morphine	112,120	Met-enkephalin	20,34	morphine	Met-enkephalin	MESH:D009020	18976(Tax:10090)	Chemical	Gene	induces|xcomp|START_ENTITY induces|nsubj|peptide peptide|nmod|END_ENTITY	Chimeric peptide of Met-enkephalin and FMRFa induces antinociception and attenuates development of tolerance to morphine antinociception .
21549695	0	morphine	92,100	NCAM	15,19	morphine	NCAM	MESH:D009020	17967(Tax:10090)	Chemical	Gene	signaling|xcomp|START_ENTITY receptor|xcomp|signaling receptor|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of NCAM and FGF receptor signaling in the development of analgesic tolerance to morphine .
26821693	0	morphine	15,23	NCAM	41,45	morphine	NCAM	MESH:D009020	24586(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|END_ENTITY	The effects of morphine treatment on the NCAM and its signaling in the MLDS of rats .
21857017	0	morphine	17,25	NET1	79,83	morphine	NET1	MESH:D009020	10276	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|role role|nmod|gene gene|compound|END_ENTITY	Direct effect of morphine on breast_cancer cell function in vitro : role of the NET1 gene .
21857017	8	morphine	974,982	NET1	986,990	morphine	NET1	MESH:D009020	10276	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	The effect of morphine on NET1 expression and migration of cells with silenced NET1 was investigated .
11805341	0	morphine	70,78	NK1_receptor	4,16	morphine	NK1 receptor	MESH:D009020	21336(Tax:10090)	Chemical	Gene	mediates|xcomp|START_ENTITY mediates|nsubj|END_ENTITY	The NK1_receptor mediates both the hyperalgesia and the resistance to morphine in mice lacking noradrenaline .
23511250	0	morphine	32,40	NPY	0,3	morphine	NPY	MESH:D009020	24604(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY mediates|dobj|activity mediates|nsubj|END_ENTITY	NPY mediates reward activity of morphine , via NPY Y1 receptors , in the nucleus accumbens shell .
23511250	0	morphine	32,40	NPY	46,49	morphine	NPY	MESH:D009020	24604(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|receptors receptors|compound|END_ENTITY	NPY mediates reward activity of morphine , via NPY Y1 receptors , in the nucleus accumbens shell .
9203557	0	morphine	74,82	Neuropeptide_FF	0,15	morphine	Neuropeptide FF	MESH:D009020	8620	Chemical	Gene	effects|nmod|START_ENTITY blocks|dobj|effects blocks|nsubj|END_ENTITY	Neuropeptide_FF in the VTA blocks the analgesic effects of both intra-VTA morphine and exposure to stress .
18992779	0	morphine	94,102	Neuropeptide_S	0,14	morphine	Neuropeptide S	MESH:D009020	100043254(Tax:10090)	Chemical	Gene	inhibits|xcomp|START_ENTITY inhibits|nsubj|END_ENTITY	Neuropeptide_S inhibits the acquisition and the expression of conditioned place preference to morphine in mice .
9454808	0	morphine	48,56	Neuropeptide_Y	0,14	morphine	Neuropeptide Y	MESH:D009020	4852	Chemical	Gene	withdrawal|compound|START_ENTITY attenuates|dobj|withdrawal attenuates|nsubj|END_ENTITY	Neuropeptide_Y attenuates naloxone-precipitated morphine withdrawal via Y5-like receptors .
10446320	0	morphine	51,59	Nociceptin	0,10	morphine	Nociceptin	MESH:D009020	25516(Tax:10116)	Chemical	Gene	tolerance|amod|START_ENTITY receptors|nmod|tolerance receptors|nsubj|END_ENTITY	Nociceptin receptors in the rat spinal cord during morphine tolerance .
17000354	0	morphine	116,124	Nociceptin	0,10	morphine	Nociceptin	MESH:D009020	5368	Chemical	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	Nociceptin levels in the cerebrospinal fluid of chronic_pain patients with or without intrathecal administration of morphine .
17156920	0	morphine	62,70	OPRM1	88,93	morphine	OPRM1	MESH:D009020	4988	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|END_ENTITY	Exploring joint effects of genes and the clinical efficacy of morphine for cancer_pain : OPRM1 and COMT gene .
25155931	0	morphine	7,15	OPRM1	77,82	morphine	OPRM1	MESH:D009020	4988	Chemical	Gene	associated|nsubj|START_ENTITY associated|nmod|END_ENTITY	Rescue morphine in mechanically ventilated newborns associated with combined OPRM1 and COMT genotype .
2991800	0	morphine	99,107	Oxytocin	0,8	morphine	Oxytocin	MESH:D009020	18429(Tax:10090)	Chemical	Gene	attenuate|nmod|START_ENTITY attenuate|nsubj|END_ENTITY	Oxytocin and a C-terminal derivative -LRB- Z-prolyl-D-leucine -RRB- attenuate tolerance to and dependence on morphine and interact with dopaminergic neurotransmission in the mouse brain .
14663457	0	morphine	76,84	P-glycoprotein	8,22	morphine	P-glycoprotein	MESH:D009020	5243	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of P-glycoprotein in the intestinal absorption and clinical effects of morphine .
20813675	0	morphine	12,20	P-glycoprotein	56,70	morphine	P-glycoprotein	MESH:D009020	67078(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of morphine and pethidine on the expression of P-glycoprotein in mouse brain microvascular endothelial cells -RSB- .
19173263	0	morphine	102,110	PKCgamma	60,68	morphine	PKCgamma	MESH:D009020	18752(Tax:10090)	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nmod|END_ENTITY	Direct evidence for the up-regulation of Vps34 regulated by PKCgamma during short-term treatment with morphine .
19282422	0	morphine	42,50	PLC-beta3	15,24	morphine	PLC-beta3	MESH:D009020	18797(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nmod|effect	Involvement of PLC-beta3 in the effect of morphine on memory retrieval in passive avoidance task .
1786530	0	morphine	22,30	Prolactin	0,9	morphine	Prolactin	MESH:D009020	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|response response|compound|END_ENTITY	Prolactin response to morphine in intact and adrenalectomized lactating rats .
3978163	0	morphine	22,30	Prolactin	0,9	morphine	Prolactin	MESH:D009020	5617	Chemical	Gene	START_ENTITY|nsubj|response response|compound|END_ENTITY	Prolactin response to morphine in depression .
4018136	0	morphine	56,64	Prolactin	0,9	morphine	Prolactin	MESH:D009020	19109(Tax:10090)	Chemical	Gene	tolerance|nmod|START_ENTITY analgesia|dep|tolerance analgesia|compound|END_ENTITY	Prolactin analgesia : tolerance and cross-tolerance with morphine .
6285470	0	morphine	40,48	Prolactin	0,9	morphine	Prolactin	MESH:D009020	24683(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|hormone hormone|compound|END_ENTITY	Prolactin and growth hormone release by morphine in the rat : different receptor mechanisms .
6330783	0	morphine	22,30	Prolactin	0,9	morphine	Prolactin	MESH:D009020	5617	Chemical	Gene	START_ENTITY|nsubj|response response|compound|END_ENTITY	Prolactin response to morphine in depression .
9645954	0	morphine	104,112	Proopiomelanocortin	0,19	morphine	Proopiomelanocortin	MESH:D009020	100720803	Chemical	Gene	down-regulation|nmod|START_ENTITY END_ENTITY|dep|down-regulation	Proopiomelanocortin -LRB- POMC -RRB- mRNA expression : distribution and region-specific down-regulation by chronic morphine in female guinea_pig hypothalamus .
6206433	0	morphine	86,94	Substance_P	0,11	morphine	Substance P	MESH:D009020	6863	Chemical	Gene	effect|nmod|START_ENTITY antagonizes|dobj|effect antagonizes|nsubj|END_ENTITY	Substance_P , injected intrathecally , antagonizes the spinal antinociceptive effect of morphine , baclofen and noradrenaline .
14741437	0	morphine	49,57	TNF-alpha	12,21	morphine	TNF-alpha	MESH:D009020	7124	Chemical	Gene	reversed|nmod|START_ENTITY reversed|nsubjpass|suppression suppression|amod|END_ENTITY	RXR-induced TNF-alpha suppression is reversed by morphine in activated U937 cells .
15934319	0	morphine	10,18	TNF-alpha	105,114	morphine	TNF-alpha	MESH:D009020	24835(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|acl|induced induced|nmod|END_ENTITY	Effect of morphine and naloxone on release of the excitatory amino_acids of spinal astrocytes induced by TNF-alpha .
9755082	0	morphine	22,30	TNF-alpha	106,115	morphine	TNF-alpha	MESH:D009020	24835(Tax:10116)	Chemical	Gene	levels|amod|START_ENTITY Effect|nmod|levels Effect|nmod|rats rats|acl|receiving receiving|dobj|injection injection|nmod|END_ENTITY	Effect of fentanyl on morphine levels in the brain in rats receiving intracerebroventricular injection of TNF-alpha .
19104749	0	morphine	60,68	Tyrosine_hydroxylase	0,20	morphine	Tyrosine hydroxylase	MESH:D009020	25085(Tax:10116)	Chemical	Gene	withdrawal|compound|START_ENTITY END_ENTITY|nmod|withdrawal	Tyrosine_hydroxylase phosphorylation after naloxone-induced morphine withdrawal in the left ventricle .
7003096	0	morphine	34,42	alcohol_dehydrogenase	67,88	morphine	alcohol dehydrogenase	MESH:D009020	78959(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY administration|nmod|END_ENTITY	Effects of castration and chronic morphine administration on liver alcohol_dehydrogenase and the metabolism of ethanol in the male Sprague-Dawley_rat .
17907742	0	morphine	67,75	angiotensin_II	11,25	morphine	angiotensin II	MESH:D009020	24179(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of angiotensin_II and captopril on rewarding properties of morphine .
19579802	0	morphine	84,92	angiotensin_II	29,43	morphine	angiotensin II	MESH:D009020	24179(Tax:10116)	Chemical	Gene	self-administration|amod|START_ENTITY accumbens|nmod|self-administration accumbens|nsubj|Effects Effects|nmod|microinjection microinjection|nmod|END_ENTITY	Effects of microinjection of angiotensin_II and captopril into nucleus accumbens on morphine self-administration in rats .
19700383	0	morphine	68,76	angiotensin_II	29,43	morphine	angiotensin II	MESH:D009020	24179(Tax:10116)	Chemical	Gene	self-administration|amod|START_ENTITY Effects|nmod|self-administration Effects|nmod|microinjection microinjection|nmod|END_ENTITY	Effects of microinjection of angiotensin_II and captopril to VTA on morphine self-administration in rats .
12846707	0	morphine	33,41	antidiuretic_hormone	45,65	morphine	antidiuretic hormone	MESH:D009020	551	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|amod|END_ENTITY	Effects of systemic and epidural morphine on antidiuretic_hormone levels in children .
8223938	0	morphine	10,18	atrial_natriuretic_factor	53,78	morphine	atrial natriuretic factor	MESH:D009020	24602(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|role role|nmod|END_ENTITY	Effect of morphine on urine output : possible role of atrial_natriuretic_factor .
9192906	0	morphine	112,120	atrial_natriuretic_factor	8,33	morphine	atrial natriuretic factor	MESH:D009020	24602(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY Role|nmod|effects Role|nmod|END_ENTITY	Role of atrial_natriuretic_factor , hemodynamic changes and renal nerves in the renal effects of intraperitoneal morphine in conscious rats .
1409804	0	morphine	70,78	atrial_natriuretic_peptide	11,37	morphine	atrial natriuretic peptide	MESH:D009020	230899(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of atrial_natriuretic_peptide on acute and chronic effects of morphine .
2901019	0	morphine	11,19	atrial_natriuretic_peptide	60,86	morphine	atrial natriuretic peptide	MESH:D009020	24602(Tax:10116)	Chemical	Gene	peptides|amod|START_ENTITY Effects|nmod|peptides Effects|nmod|END_ENTITY	Effects of morphine and opioid peptides on plasma levels of atrial_natriuretic_peptide .
1416198	0	morphine	82,90	beta-endorphin	33,47	morphine	beta-endorphin	MESH:D009020	5443	Chemical	Gene	analgesia|amod|START_ENTITY END_ENTITY|nmod|analgesia	-LSB- Changes in the concentration of beta-endorphin in the cerebrospinal fluid due to morphine analgesia in incurable oncologic patients -RSB- .
1608292	0	morphine	58,66	beta-endorphin	21,35	morphine	beta-endorphin	MESH:D009020	5443	Chemical	Gene	withdrawal_syndrome|amod|START_ENTITY alleviates|dep|withdrawal_syndrome N-acetyl|dep|alleviates N-acetyl|dep|END_ENTITY	alpha N-acetyl human beta-endorphin - -LRB- 1-31 -RRB- alleviates the morphine withdrawal_syndrome in rodents : a comparative study with clonidine .
19563707	0	morphine	80,88	beta-endorphin	125,139	morphine	beta-endorphin	MESH:D009020	5443	Chemical	Gene	combined|nmod|START_ENTITY combined|nmod|level level|amod|END_ENTITY	-LSB- Effects of patient-controlled analgesia with small dose ketamine combined with morphine and the influence thereof on plasma beta-endorphin level in patients after radical operation for esophageal_carcinoma -RSB- .
2951622	0	morphine	20,28	beta-endorphin	41,55	morphine	beta-endorphin	MESH:D009020	5443	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|role role|nmod|END_ENTITY	Analgesic effect of morphine : a role for beta-endorphin .
2971429	0	morphine	76,84	beta-endorphin	24,38	morphine	beta-endorphin	MESH:D009020	5443	Chemical	Gene	-RSB-|compound|START_ENTITY postoperative_pain|nmod|-RSB- -LSB-|advcl|postoperative_pain -LSB-|dobj|response response|nmod|END_ENTITY	-LSB- The response of plasma beta-endorphin to postoperative_pain after epidural morphine -RSB- .
6087663	0	morphine	22,30	beta-endorphin	63,77	morphine	beta-endorphin	MESH:D009020	5443	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Effect of intrathecal morphine during labor on maternal plasma beta-endorphin levels .
6276911	0	morphine	80,88	beta-endorphin	22,36	morphine	beta-endorphin	MESH:D009020	5443	Chemical	Gene	usage|compound|START_ENTITY predict|dobj|usage predict|nsubj|END_ENTITY	Stress-induced plasma beta-endorphin immunoreactivity may predict postoperative morphine usage .
6297355	0	morphine	16,24	beta-endorphin	76,90	morphine	beta-endorphin	MESH:D009020	5443	Chemical	Gene	actions|nmod|START_ENTITY actions|dep|actions actions|nmod|END_ENTITY	Dual actions of morphine on the central nervous system : parallel actions of beta-endorphin and ACTH .
6329787	0	morphine	43,51	beta-endorphin	11,25	morphine	beta-endorphin	MESH:D009020	5443	Chemical	Gene	growth_hormone|amod|START_ENTITY 6-31|nmod|growth_hormone 6-31|amod|END_ENTITY	Effects of beta-endorphin fragment 6-31 on morphine - and beta-endorphin-induced growth_hormone and prolactin release .
731437	0	morphine	34,42	beta-endorphin	44,58	morphine	beta-endorphin	MESH:D009020	18976(Tax:10090)	Chemical	Gene	naloxone|nmod|START_ENTITY antagonism|nmod|naloxone analog|nmod|antagonism analog|nsubj|END_ENTITY	In vivo antagonism by naloxone of morphine , beta-endorphin and a synthetic enkephalin analog .
8223926	0	morphine	111,119	beta-endorphin	67,81	morphine	beta-endorphin	MESH:D009020	18976(Tax:10090)	Chemical	Gene	intracerebroventricular|nmod|START_ENTITY intracerebroventricular|dobj|tolerant tolerant|amod|END_ENTITY	Partial antinociceptive cross-tolerance to intracerebroventricular beta-endorphin in mice tolerant to systemic morphine .
10095048	0	morphine	62,70	c-Fos	93,98	morphine	c-Fos	MESH:D009020	314322(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY antagonists|nmod|effects Effects|nmod|antagonists evoked|nsubj|Effects evoked|dobj|expression expression|amod|END_ENTITY	Effects of opioid receptor antagonists on the effects of i.v. morphine on carrageenin evoked c-Fos expression in the superficial dorsal horn of the rat spinal cord .
10408246	0	morphine	40,48	c-Fos	62,67	morphine	c-Fos	MESH:D009020	314322(Tax:10116)	Chemical	Gene	tolerance|amod|START_ENTITY antagonists|nmod|tolerance Effects|nmod|antagonists Effects|dep|study study|amod|END_ENTITY	Effects of NMDA receptor antagonists on morphine tolerance : a c-Fos study in the lumbar spinal cord of the rat .
11163637	0	morphine	135,143	c-Fos	107,112	morphine	c-Fos	MESH:D009020	14281(Tax:10090)	Chemical	Gene	dependent|amod|START_ENTITY mice|amod|dependent expression|nmod|mice expression|amod|END_ENTITY	A selective phosphodiesterase IV inhibitor , rolipram blocks both withdrawal behavioral manifestations , and c-Fos protein expression in morphine dependent mice .
15175841	0	morphine	93,101	c-Fos	19,24	morphine	c-Fos	MESH:D009020	314322(Tax:10116)	Chemical	Gene	exposure|compound|START_ENTITY h|nmod|exposure centromedial|dobj|h centromedial|nsubj|expression expression|amod|END_ENTITY	Withdrawal-induced c-Fos expression in the rat centromedial amygdala 24 h following a single morphine exposure .
16190878	0	morphine	97,105	c-Fos	50,55	morphine	c-Fos	MESH:D009020	314322(Tax:10116)	Chemical	Gene	withdrawal|compound|START_ENTITY isoforms|nmod|withdrawal isoforms|nmod|regulation regulation|nmod|END_ENTITY	Role of PKC-alpha , gamma isoforms in regulation of c-Fos and TH expression after naloxone-induced morphine withdrawal in the hypothalamic PVN and medulla oblongata catecholaminergic cell groups .
17631915	0	morphine	118,126	c-Fos	13,18	morphine	c-Fos	MESH:D009020	314322(Tax:10116)	Chemical	Gene	exposed|xcomp|START_ENTITY exposed|nsubj|Induction Induction|nmod|END_ENTITY	Induction of c-Fos and zif268 in the nociceptive_amygdala parallel abstinence_hyperalgesia in rats briefly exposed to morphine .
17873287	0	morphine	43,51	c-Fos	60,65	morphine	c-Fos	MESH:D009020	314322(Tax:10116)	Chemical	Gene	START_ENTITY|acl|induced induced|dobj|expression expression|amod|END_ENTITY	Gabapentin completely attenuated the acute morphine induced c-Fos expression in the rat striatum .
23152154	0	morphine	67,75	c-Fos	43,48	morphine	c-Fos	MESH:D009020	14281(Tax:10090)	Chemical	Gene	withdrawal_syndrome|amod|START_ENTITY modify|nmod|withdrawal_syndrome modify|dobj|expression expression|amod|END_ENTITY	Baclofen did not modify sexually dimorphic c-Fos expression during morphine withdrawal_syndrome .
7675199	0	morphine	76,84	c-Fos	95,100	morphine	c-Fos	MESH:D009020	314322(Tax:10116)	Chemical	Gene	dose|nmod|START_ENTITY ability|nmod|dose enhances|dobj|ability enhances|xcomp|reduce reduce|dobj|expression expression|amod|END_ENTITY	Cholecystokinin_B receptor antagonism enhances the ability of a low dose of morphine to reduce c-Fos expression in the spinal cord of the rat .
8762093	0	morphine	13,21	c-Fos	39,44	morphine	c-Fos	MESH:D009020	314322(Tax:10116)	Chemical	Gene	depresses|nsubj|START_ENTITY depresses|dobj|expression expression|amod|END_ENTITY	Intraplantar morphine depresses spinal c-Fos expression induced by carrageenin inflammation but not by noxious heat .
8821738	0	morphine	56,64	c-Fos	94,99	morphine	c-Fos	MESH:D009020	314322(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	When is the maximal effect of pre-administered systemic morphine on carrageenin evoked spinal c-Fos expression in the rat ?
8925281	0	morphine	70,78	c-Fos	15,20	morphine	c-Fos	MESH:D009020	314322(Tax:10116)	Chemical	Gene	colorectal_distention|amod|START_ENTITY lumbosacral|nmod|colorectal_distention lumbosacral|nsubj|Attenuation Attenuation|nmod|expression expression|amod|END_ENTITY	Attenuation of c-Fos expression in the rat lumbosacral spinal cord by morphine or tramadol following noxious colorectal_distention .
9200179	0	morphine	117,125	c-Fos	189,194	morphine	c-Fos	MESH:D009020	314322(Tax:10116)	Chemical	Gene	treatment|nmod|START_ENTITY treatment|acl|induced induced|dobj|expression expression|compound|END_ENTITY	Chronic treatment with systemic morphine induced tolerance to the systemic and peripheral antinociceptive effects of morphine on both carrageenin induced mechanical_hyperalgesia and spinal c-Fos expression in awake rats .
9200179	0	morphine	32,40	c-Fos	189,194	morphine	c-Fos	MESH:D009020	314322(Tax:10116)	Chemical	Gene	treatment|nmod|START_ENTITY treatment|acl|induced induced|dobj|expression expression|compound|END_ENTITY	Chronic treatment with systemic morphine induced tolerance to the systemic and peripheral antinociceptive effects of morphine on both carrageenin induced mechanical_hyperalgesia and spinal c-Fos expression in awake rats .
9824685	0	morphine	67,75	c-Fos	111,116	morphine	c-Fos	MESH:D009020	314322(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY tolerance|nmod|effect Development|nmod|tolerance Development|dep|study study|amod|END_ENTITY	Development of tolerance to the antinociceptive effect of systemic morphine at the lumbar spinal cord level : a c-Fos study in the rat .
10521594	0	morphine	35,43	c-fos	89,94	morphine	c-fos	MESH:D009020	314322(Tax:10116)	Chemical	Gene	sensitization|nmod|START_ENTITY determined|nsubj|sensitization determined|nmod|expression expression|amod|END_ENTITY	Long-lasting sensitization towards morphine in motoric and limbic areas as determined by c-fos expression in rat brain .
10648731	0	morphine	6,14	c-fos	36,41	morphine	c-fos	MESH:D009020	314322(Tax:10116)	Chemical	Gene	withdrawal|compound|START_ENTITY increases|nsubj|withdrawal increases|dobj|gene gene|amod|END_ENTITY	Local morphine withdrawal increases c-fos gene , Fos protein , and oxytocin gene expression in hypothalamic magnocellular neurosecretory cells .
10814832	0	morphine	20,28	c-fos	52,57	morphine	c-fos	MESH:D009020	314322(Tax:10116)	Chemical	Gene	application|amod|START_ENTITY experience|nmod|application alters|nsubj|experience alters|dobj|response response|amod|END_ENTITY	Prior experience of morphine application alters the c-fos response to MDMA -LRB- ` ecstasy ' -RRB- and cocaine in the rat striatum .
11122358	0	morphine	53,61	c-fos	11,16	morphine	c-fos	MESH:D009020	314322(Tax:10116)	Chemical	Gene	dependence|amod|START_ENTITY Mapping|nmod|dependence Mapping|nmod|expression expression|amod|END_ENTITY	Mapping of c-fos gene expression in the brain during morphine dependence and precipitated withdrawal , and phenotypic identification of the striatal neurons involved .
11340648	0	morphine	39,47	c-fos	85,90	morphine	c-fos	MESH:D009020	314322(Tax:10116)	Chemical	Gene	withdrawal|amod|START_ENTITY Y|nmod|withdrawal effect|nmod|Y accompanied|nsubjpass|effect accompanied|nmod|expression expression|amod|END_ENTITY	Inhibitory effect of neuropeptide Y on morphine withdrawal is accompanied by reduced c-fos expression in specific brain regions .
11698063	0	morphine	63,71	c-fos	94,99	morphine	c-fos	MESH:D009020	314322(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Characterization of the signal transduction pathways mediating morphine withdrawal-stimulated c-fos expression in hypothalamic nuclei .
12499582	0	morphine	22,30	c-fos	63,68	morphine	c-fos	MESH:D009020	2353	Chemical	Gene	elicits|amod|START_ENTITY increases|nsubj|elicits increases|nmod|expression expression|amod|END_ENTITY	Naloxone-precipitated morphine withdrawal elicits increases in c-fos mRNA expression in restricted regions of the infant rat brain .
12598416	0	morphine	50,58	c-fos	14,19	morphine	c-fos	MESH:D009020	314322(Tax:10116)	Chemical	Gene	withdrawal|amod|START_ENTITY heart|nmod|withdrawal Activation|nmod|heart Activation|nmod|expression expression|amod|END_ENTITY	Activation of c-fos expression in the heart after morphine but not U-50 ,488 H withdrawal .
15147776	0	morphine	32,40	c-fos	55,60	morphine	c-fos	MESH:D009020	314322(Tax:10116)	Chemical	Gene	withdrawal|compound|START_ENTITY withdrawal|nmod|expression expression|amod|END_ENTITY	Effect of naloxone-precipitated morphine withdrawal on c-fos expression in rat corticotropin-releasing_hormone neurons in the paraventricular_hypothalamus and extended amygdala .
15249992	0	morphine	52,60	c-fos	11,16	morphine	c-fos	MESH:D009020	314322(Tax:10116)	Chemical	Gene	withdrawal|amod|START_ENTITY Changes|nmod|withdrawal Changes|nmod|expression expression|amod|END_ENTITY	Changes in c-fos expression in the rat heart during morphine withdrawal .
15977398	0	morphine	104,112	c-fos	56,61	morphine	c-fos	MESH:D009020	14281(Tax:10090)	Chemical	Gene	addicted|dep|START_ENTITY mice|amod|addicted hippocampus|nmod|mice cleaving|nmod|hippocampus cleaving|nmod|mRNA mRNA|amod|END_ENTITY	-LSB- The effect of ribozyme specially cleaving per1 mRNA on c-fos mRNA and its expression in hippocampus of morphine addicted mice -RSB- .
7624831	0	morphine	61,69	c-fos	37,42	morphine	c-fos	MESH:D009020	314322(Tax:10116)	Chemical	Gene	withdrawal|amod|START_ENTITY block|nmod|withdrawal block|dobj|expression expression|amod|END_ENTITY	NMDA antagonists and clonidine block c-fos expression during morphine withdrawal .
7755894	0	morphine	86,94	c-fos	43,48	morphine	c-fos	MESH:D009020	2353	Chemical	Gene	administration|amod|START_ENTITY striatum|nmod|administration mediate|nmod|striatum mediate|dobj|induction induction|nmod|genes genes|amod|END_ENTITY	NMDA and D1 receptors mediate induction of c-fos and junB genes in striatum following morphine administration : implications for studies of memory .
9673793	0	morphine	54,62	c-fos	11,16	morphine	c-fos	MESH:D009020	314322(Tax:10116)	Chemical	Gene	induction|nmod|START_ENTITY induction|nsubj|Pattern Pattern|nmod|mRNA mRNA|amod|END_ENTITY	Pattern of c-fos mRNA induction in rat brain by acute morphine .
14598307	0	morphine	54,62	calcitonin_gene-related_peptide	19,50	morphine	calcitonin gene-related peptide	MESH:D009020	24241(Tax:10116)	Chemical	Gene	tolerance|amod|START_ENTITY END_ENTITY|nmod|tolerance	Plastic changes of calcitonin_gene-related_peptide in morphine tolerance : behavioral and immunohistochemical study in rats .
19491327	0	morphine	10,18	calcitonin_gene-related_peptide	55,86	morphine	calcitonin gene-related peptide	MESH:D009020	796	Chemical	Gene	treatment|compound|START_ENTITY augments|nsubj|treatment augments|ccomp|kinase kinase|nsubj|release release|amod|END_ENTITY	Sustained morphine treatment augments capsaicin-evoked calcitonin_gene-related_peptide release from primary sensory neurons in a protein kinase A - and Raf-1-dependent manner .
20826131	0	morphine	10,18	calcitonin_gene-related_peptide	62,93	morphine	calcitonin gene-related peptide	MESH:D009020	796	Chemical	Gene	treatment|compound|START_ENTITY augments|nsubj|treatment augments|dobj|release release|amod|END_ENTITY	Sustained morphine treatment augments prostaglandin_E2-evoked calcitonin_gene-related_peptide release from primary sensory neurons in a PKA-dependent manner .
23570731	0	morphine	94,102	calcitonin_gene-related_peptide	14,45	morphine	calcitonin gene-related peptide	MESH:D009020	796	Chemical	Gene	treatment|amod|START_ENTITY neurons|nmod|treatment subunits|nmod|neurons subunits|nsubj|Expression Expression|nmod|receptor receptor|amod|END_ENTITY	Expression of calcitonin_gene-related_peptide receptor subunits in cultured neurons following morphine treatment .
2552070	0	morphine	44,52	calcitonin_gene-related_peptide	186,217	morphine	calcitonin gene-related peptide	MESH:D009020	12310(Tax:10090)	Chemical	Gene	produced|nmod|START_ENTITY -RSB-|ccomp|produced -RSB-|nmod|administration administration|nmod|END_ENTITY	The antinociception produced by intrathecal morphine , calcium , A23187 , U50 ,488 H , -LSB- D-Ala2 , _ N-Me-Phe4 , _ Gly-ol -RSB- enkephalin and -LSB- D-Pen2 , D-Pen5 -RSB- enkephalin after intrathecal administration of calcitonin_gene-related_peptide in mice .
8545480	0	morphine	75,83	calcitonin_gene-related_peptide	11,42	morphine	calcitonin gene-related peptide	MESH:D009020	24241(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of calcitonin_gene-related_peptide on acute and chronic effects of morphine .
8601814	0	morphine	102,110	calcitonin_gene-related_peptide	2,33	morphine	calcitonin gene-related peptide	MESH:D009020	24241(Tax:10116)	Chemical	Gene	analgesia|compound|START_ENTITY prevents|nmod|analgesia prevents|nsubj|antagonist antagonist|amod|END_ENTITY	A calcitonin_gene-related_peptide receptor antagonist prevents the development of tolerance to spinal morphine analgesia .
9596344	0	morphine	43,51	cholecystokinin	24,39	morphine	cholecystokinin	MESH:D009020	25298(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY release|nmod|END_ENTITY	Differential release of cholecystokinin by morphine in rat spinal cord .
11224314	0	morphine	98,106	corticotropin-releasing_factor	15,45	morphine	corticotropin-releasing factor	MESH:D009020	1392	Chemical	Gene	withdrawal|amod|START_ENTITY consequences|nmod|withdrawal attenuates|dobj|consequences attenuates|nsubj|Suppression Suppression|nmod|END_ENTITY	Suppression of corticotropin-releasing_factor in the amygdala attenuates aversive consequences of morphine withdrawal .
11711043	0	morphine	68,76	corticotropin-releasing_factor	15,45	morphine	corticotropin-releasing factor	MESH:D009020	12918(Tax:10090)	Chemical	Gene	regulation|amod|START_ENTITY subtype|nmod|regulation subtype|nsubj|Involvement Involvement|nmod|receptor receptor|amod|END_ENTITY	Involvement of corticotropin-releasing_factor receptor subtype 1 in morphine withdrawal regulation of the brain noradrenergic system .
12716409	0	morphine	121,129	corticotropin-releasing_factor	25,55	morphine	corticotropin-releasing factor	MESH:D009020	81648(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY hypothalamus|nmod|treatment mRNA|nmod|hypothalamus mRNA|compound|END_ENTITY	Quantitative analysis of corticotropin-releasing_factor and arginine_vasopressin mRNA in the hypothalamus during chronic morphine treatment in rats : an in situ hybridization study .
1352026	0	morphine	20,28	corticotropin-releasing_factor	42,72	morphine	corticotropin-releasing factor	MESH:D009020	12918(Tax:10090)	Chemical	Gene	tolerance|compound|START_ENTITY tolerance|nmod|END_ENTITY	Modulation of acute morphine tolerance by corticotropin-releasing_factor and dynorphin_A in the mouse spinal cord .
15385601	0	morphine	8,16	corticotropin-releasing_factor	63,93	morphine	corticotropin-releasing factor	MESH:D009020	81648(Tax:10116)	Chemical	Gene	sensitizes|nsubj|START_ENTITY sensitizes|nmod|END_ENTITY	Chronic morphine sensitizes the brain norepinephrine system to corticotropin-releasing_factor and stress .
1848633	0	morphine	14,22	corticotropin-releasing_factor	69,99	morphine	corticotropin-releasing factor	MESH:D009020	12918(Tax:10090)	Chemical	Gene	Antagonism|nmod|START_ENTITY antinociception|nsubj|Antagonism antinociception|nmod|END_ENTITY	Antagonism of morphine antinociception by intrathecally administered corticotropin-releasing_factor in mice .
20159948	0	morphine	105,113	corticotropin-releasing_factor	11,41	morphine	corticotropin-releasing factor	MESH:D009020	81648(Tax:10116)	Chemical	Gene	stress|xcomp|START_ENTITY stress|nsubj|Effects Effects|nmod|antagonists antagonists|amod|END_ENTITY	Effects of corticotropin-releasing_factor receptor-1 antagonists on the brain stress system responses to morphine withdrawal .
23071721	0	morphine	93,101	corticotropin-releasing_factor	8,38	morphine	corticotropin-releasing factor	MESH:D009020	81648(Tax:10116)	Chemical	Gene	response|acl|START_ENTITY receptor-1|nmod|response accumbens|amod|receptor-1 accumbens|amod|END_ENTITY	Role of corticotropin-releasing_factor -LRB- CRF -RRB- receptor-1 on the catecholaminergic response to morphine withdrawal in the nucleus accumbens -LRB- NAc -RRB- .
3004111	0	morphine	11,19	corticotropin-releasing_factor	36,66	morphine	corticotropin-releasing factor	MESH:D009020	81648(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of morphine on hypothalamic corticotropin-releasing_factor -LRB- CRF -RRB- , norepinephrine and dopamine in non-stressed and stressed rats .
3024953	0	morphine	10,18	corticotropin-releasing_factor	35,65	morphine	corticotropin-releasing factor	MESH:D009020	81648(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of morphine on hypothalamic corticotropin-releasing_factor -LRB- CRF -RRB- and pituitary-adrenocortical activity .
9402040	0	morphine	106,114	corticotropin-releasing_factor	27,57	morphine	corticotropin-releasing factor	MESH:D009020	81648(Tax:10116)	Chemical	Gene	administration|amod|START_ENTITY regions|nmod|administration regulation|nmod|regions regulation|nmod|END_ENTITY	Differential regulation of corticotropin-releasing_factor and vasopressin in discrete brain regions after morphine administration : correlations with hypothalamic noradrenergic activity and pituitary-adrenal response .
9580616	0	morphine	90,98	corticotropin-releasing_factor	15,45	morphine	corticotropin-releasing factor	MESH:D009020	81648(Tax:10116)	Chemical	Gene	withdrawal|amod|START_ENTITY brain|nmod|withdrawal content|nmod|brain content|compound|END_ENTITY	Alterations in corticotropin-releasing_factor and vasopressin content in rat brain during morphine withdrawal : correlation with hypothalamic noradrenergic activity and pituitary-adrenal response .
3033966	0	morphine	15,23	corticotropin-releasing_hormone	91,122	morphine	corticotropin-releasing hormone	MESH:D009020	1392	Chemical	Gene	Effect|nmod|START_ENTITY Effect|acl|induced induced|nmod|END_ENTITY	Effect of oral morphine and naloxone on pituitary-adrenal response in man induced by human corticotropin-releasing_hormone .
1660817	0	morphine	122,130	enkephalin	89,99	morphine	enkephalin	MESH:D009020	29237(Tax:10116)	Chemical	Gene	rats|amod|START_ENTITY membranes|nmod|rats END_ENTITY|nmod|membranes	Differences in the binding of -LSB- 3H -RSB- -LSB- D-Ser2 , Thr6 -RSB- leucine-enkephalin and -LSB- 3H -RSB- -LSB- D-Pen2 , D-Pen5 -RSB- enkephalin to brain membranes of morphine tolerant-dependent rats .
1797559	0	morphine	55,63	enkephalin	82,92	morphine	enkephalin	MESH:D009020	29237(Tax:10116)	Chemical	Gene	withdrawal|nmod|START_ENTITY Characteristics|nmod|withdrawal Characteristics|dep|changes changes|nmod|levels levels|compound|END_ENTITY	Characteristics of precipitated withdrawal from spinal morphine : changes in -LSB- Met5 -RSB- enkephalin levels .
1847734	0	morphine	157,165	enkephalin	40,50	morphine	enkephalin	MESH:D009020	29237(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY and|dep|effect and|dep|increase increase|compound|END_ENTITY	Morphine and -LRB- D-Ala2 , NMe-Phe4 , Gly-ol -RRB- - enkephalin increase the intracellular free calcium in isolated rat myocytes -- effect of naloxone or pretreatment with morphine .
18761380	0	morphine	83,91	enkephalin	19,29	morphine	enkephalin	MESH:D009020	29237(Tax:10116)	Chemical	Gene	withdrawal|compound|START_ENTITY signs|nmod|withdrawal attenuates|dobj|signs attenuates|nsubj|expression expression|compound|END_ENTITY	Transgene-mediated enkephalin expression attenuates signs of naloxone-precipitated morphine withdrawal in rats with neuropathic_pain .
2453939	0	morphine	98,106	enkephalin	24,34	morphine	enkephalin	MESH:D009020	29237(Tax:10116)	Chemical	Gene	containing|advcl|START_ENTITY P|xcomp|containing P|nsubj|ontogenesis ontogenesis|nmod|END_ENTITY	Modified ontogenesis of enkephalin and substance P containing neurons after perinatal exposure to morphine .
2540993	0	morphine	26,34	enkephalin	124,134	morphine	enkephalin	MESH:D009020	29237(Tax:10116)	Chemical	Gene	sites|amod|START_ENTITY administration|nmod|sites labeled|nsubj|administration labeled|nmod|END_ENTITY	Chronic administration of morphine and naltrexone up-regulate mu-opioid binding sites labeled by -LSB- 3H -RSB- -LSB- D-Ala2 , MePhe4,Gly-ol5 -RSB- enkephalin : further evidence for two mu-binding sites .
2838332	0	morphine	155,163	enkephalin	83,93	morphine	enkephalin	MESH:D009020	29237(Tax:10116)	Chemical	Gene	mu|nmod|START_ENTITY mu|nsubj|ligand ligand|nmod|receptors receptors|dep|Phe Phe|dep|analog analog|compound|END_ENTITY	A highly selective ligand for brain delta opiate receptors , a cyclopropyl -LRB- E -RRB- Phe -LRB- 4 -RRB- - enkephalin analog , suppresses mu receptor-mediated thermal analgesia by morphine .
2847072	0	morphine	26,34	enkephalin	80,90	morphine	enkephalin	MESH:D009020	29237(Tax:10116)	Chemical	Gene	-RSB-|amod|START_ENTITY administration|nmod|-RSB- END_ENTITY|nsubj|administration	Chronic administration of morphine and naltrexone up-regulate -LSB- 3H -RSB- -LSB- D-Ala2 , D-leu5 -RSB- enkephalin binding sites by different mechanisms .
3295587	0	morphine	21,29	enkephalin	48,58	morphine	enkephalin	MESH:D009020	29237(Tax:10116)	Chemical	Gene	D-Ala2|amod|START_ENTITY -RSB-|amod|D-Ala2 action|nmod|-RSB- action|dep|END_ENTITY	Convulsant action of morphine , -LSB- D-Ala2 , _ D-Leu5 -RSB- - enkephalin and naloxone in the rat amygdala : electroencephalographic , morphological and behavioural sequelae .
6170377	0	morphine	22,30	enkephalin	91,101	morphine	enkephalin	MESH:D009020	29237(Tax:10116)	Chemical	Gene	effect|acl|START_ENTITY opioid|nsubj|effect opioid|dobj|END_ENTITY	Contractile effect of morphine and related opioid alkaloids , beta-endorphin and methionine enkephalin on the isolated colon from Long Evans rats .
8872371	0	morphine	32,40	enkephalin	93,103	morphine	enkephalin	MESH:D009020	29237(Tax:10116)	Chemical	Gene	abstinence|compound|START_ENTITY decrease|nmod|abstinence decrease|appos|inhibitor inhibitor|nmod|catabolism catabolism|compound|END_ENTITY	Similar decrease in spontaneous morphine abstinence by methadone and RB_101 , an inhibitor of enkephalin catabolism .
11988336	0	morphine	37,45	extracellular_signal_regulated_kinase	65,102	morphine	extracellular signal regulated kinase	MESH:D009020	26413(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of repeated administration of morphine on the activity of extracellular_signal_regulated_kinase in the mouse brain .
8764658	0	morphine	174,182	extracellular_signal_regulated_kinase	19,56	morphine	extracellular signal regulated kinase	MESH:D009020	24338(Tax:10116)	Chemical	Gene	dopamine|nmod|START_ENTITY dopamine|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of ERK -LRB- extracellular_signal_regulated_kinase -RRB- , part of the neurotrophin signal transduction cascade , in the rat mesolimbic dopamine system by chronic exposure to morphine or cocaine .
16044040	0	morphine	23,31	fos	66,69	morphine	fos	MESH:D009020	314322(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of pre-emptive morphine , ibuprofen or local anesthetic on fos expression in the spinal trigeminal nucleus following tooth pulp exposure in the rat .
2163480	0	morphine	45,53	fos	4,7	morphine	fos	MESH:D009020	314322(Tax:10116)	Chemical	Gene	hypothalamus|amod|START_ENTITY regulation|nmod|hypothalamus protein|dep|regulation protein|amod|END_ENTITY	The fos proto-oncogene protein : regulation by morphine in the rat hypothalamus .
16879618	0	morphine	20,28	glial_cell_line-derived_neurotrophic_factor	90,133	morphine	glial cell line-derived neurotrophic factor	MESH:D009020	14573(Tax:10090)	Chemical	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Effects of repeated morphine on locomotion , place preference and dopamine in heterozygous glial_cell_line-derived_neurotrophic_factor knockout mice .
1234764	0	morphine	6,14	growth_hormone	49,63	morphine	growth hormone	MESH:D009020	81668(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|effects effects|amod|END_ENTITY	Acute morphine effects on regional brain amines , growth_hormone and corticosterone .
1234768	0	morphine	8,16	growth_hormone	51,65	morphine	growth hormone	MESH:D009020	81668(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|effects effects|amod|END_ENTITY	Chronic morphine effects on regional brain amines , growth_hormone and corticosterone .
6105900	0	morphine	77,85	growth_hormone	89,103	morphine	growth hormone	MESH:D009020	81668(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY mediating|dobj|effects mediating|nmod|END_ENTITY	Role of central nervous system neurotransmitters in mediating the effects of morphine on growth_hormone - and prolactin-secretion in the rat .
647491	0	morphine	25,33	growth_hormone	42,56	morphine	growth hormone	MESH:D009020	2688	Chemical	Gene	secretion|compound|START_ENTITY secretion|compound|END_ENTITY	Antagonism by taurine of morphine induced growth_hormone secretion .
7145019	0	morphine	120,128	growth_hormone	72,86	morphine	growth hormone	MESH:D009020	81668(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY release|acl|induced release|compound|END_ENTITY	Neonatal treatment with monosodium-L-glutamate : differential effects on growth_hormone and prolactin release induced by morphine .
3512343	0	morphine	13,21	insulin	44,51	morphine	insulin	MESH:D009020	3630	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	Reduction by morphine of human postprandial insulin release is secondary to inhibition of gastrointestinal_motility .
6991319	0	morphine	36,44	insulin	50,57	morphine	insulin	MESH:D009020	3630	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Disparate effects of enkephalin and morphine upon insulin and glucagon secretion by islet cell cultures .
7006411	0	morphine	18,26	insulin	78,85	morphine	insulin	MESH:D009020	704534(Tax:9544)	Chemical	Gene	Lack|nmod|START_ENTITY Lack|nmod|END_ENTITY	Lack of effect of morphine , reserpine , and halothane on oscillation of plasma insulin in M. _ mulatta .
8701766	0	morphine	10,18	interleukin-1_and_tumor_necrosis_factor_alpha	22,67	morphine	interleukin-1 and tumor necrosis factor alpha	MESH:D009020	21926(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Effect of morphine on interleukin-1_and_tumor_necrosis_factor_alpha production from mouse peritoneal macrophages in vitro .
15030578	0	morphine	45,53	interleukin-1beta	15,32	morphine	interleukin-1beta	MESH:D009020	16176(Tax:10090)	Chemical	Gene	effects|compound|START_ENTITY END_ENTITY|nmod|effects	Involvement of interleukin-1beta in systemic morphine effects on paw oedema in a mouse model of acute inflammation .
17227776	0	morphine	88,96	interleukin-2	45,58	morphine	interleukin-2	MESH:D009020	3558	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|gene gene|compound|END_ENTITY	Transcriptional and epigenetic regulation of interleukin-2 gene in activated T cells by morphine .
6128692	1	morphine	157,165	melanotropin-release_inhibiting_factor	90,128	morphine	melanotropin-release inhibiting factor	MESH:D009020	81683(Tax:10116)	Chemical	Gene	Effect|acl|START_ENTITY Effect|nmod|END_ENTITY	Effect of melanotropin-release_inhibiting_factor and analogs on tolerance to morphine in the rat .
6120229	1	morphine	156,164	melanotropin_release_inhibiting_factor	89,127	morphine	melanotropin release inhibiting factor	MESH:D009020	81683(Tax:10116)	Chemical	Gene	Effect|acl|START_ENTITY Effect|nmod|END_ENTITY	I. Effect of melanotropin_release_inhibiting_factor and analogs on tolerance to morphine in the rat .
2483754	0	morphine	101,109	met-enkephalin	29,43	morphine	met-enkephalin	MESH:D009020	5443	Chemical	Gene	exposed|xcomp|START_ENTITY animals|acl|exposed altered|nmod|animals altered|nsubjpass|pattern pattern|nmod|innervation innervation|amod|END_ENTITY	The developmental pattern of met-enkephalin innervation is altered in animals perinatally exposed to morphine .
3837860	0	morphine	45,53	met-enkephalin	71,85	morphine	met-enkephalin	MESH:D009020	18976(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of phencyclidine in combination with morphine on the levels of met-enkephalin , dopamine , DOPAC and HVA in discrete brain areas of mice .
19144786	0	morphine	10,18	miRNA23b	112,120	morphine	miRNA23b	MESH:D009020	407011	Chemical	Gene	treatment|compound|START_ENTITY decreases|nsubj|treatment decreases|nmod|END_ENTITY	Long-term morphine treatment decreases the association of mu-opioid_receptor -LRB- MOR1 -RRB- mRNA with polysomes through miRNA23b .
22342918	0	morphine	100,108	midkine	35,42	morphine	midkine	MESH:D009020	17242(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY regulate|dobj|effects regulate|nsubj|END_ENTITY	The heparin binding growth factors midkine and pleiotrophin regulate the antinociceptive effects of morphine through a -LRB- 2 -RRB- - adrenergic independent mechanisms .
2539233	0	morphine	8,16	mu-opiate_receptor	27,45	morphine	mu-opiate receptor	MESH:D009020	29256(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Chronic morphine increases mu-opiate_receptor binding in rat brain : a quantitative autoradiographic study .
17897634	0	morphine	8,16	mu_opioid_receptor	40,58	morphine	mu opioid receptor	MESH:D009020	4988	Chemical	Gene	up-regulates|amod|START_ENTITY END_ENTITY|nsubj|up-regulates	Chronic morphine treatment up-regulates mu_opioid_receptor binding in cells lacking filamin_A .
18068348	0	morphine	66,74	mu_opioid_receptor	12,30	morphine	mu opioid receptor	MESH:D009020	4988	Chemical	Gene	tolerance|amod|START_ENTITY role|nmod|tolerance role|nmod|desensitization desensitization|compound|END_ENTITY	The role of mu_opioid_receptor desensitization and endocytosis in morphine tolerance and dependence .
2548212	0	morphine	70,78	mu_opioid_receptor	21,39	morphine	mu opioid receptor	MESH:D009020	100379267(Tax:10141)	Chemical	Gene	exposure|compound|START_ENTITY induced|nmod|exposure induced|nsubj|changes changes|nmod|properties properties|compound|END_ENTITY	Selective changes in mu_opioid_receptor properties induced by chronic morphine exposure .
7583338	0	morphine	76,84	mu_opioid_receptor	14,32	morphine	mu opioid receptor	MESH:D009020	25601(Tax:10116)	Chemical	Gene	mRNA|nmod|START_ENTITY mRNA|nsubj|levels levels|nmod|END_ENTITY	CNS levels of mu_opioid_receptor -LRB- MOR-1 -RRB- mRNA during chronic treatment with morphine or naltrexone .
9618432	0	morphine	127,135	mu_opioid_receptor	207,225	morphine	mu opioid receptor	MESH:D009020	100379267(Tax:10141)	Chemical	Gene	treatment|compound|START_ENTITY treatment|amod|convergence convergence|nmod|pathway pathway|nmod|estrogen estrogen|nmod|coupling coupling|compound|END_ENTITY	Protein kinase A maintains cellular tolerance to mu_opioid_receptor agonists in hypothalamic neurosecretory cells with chronic morphine treatment : convergence on a common pathway with estrogen in modulating mu_opioid_receptor / effector coupling .
9618432	0	morphine	127,135	mu_opioid_receptor	49,67	morphine	mu opioid receptor	MESH:D009020	100379267(Tax:10141)	Chemical	Gene	treatment|compound|START_ENTITY END_ENTITY|nmod|treatment	Protein kinase A maintains cellular tolerance to mu_opioid_receptor agonists in hypothalamic neurosecretory cells with chronic morphine treatment : convergence on a common pathway with estrogen in modulating mu_opioid_receptor / effector coupling .
12372907	0	morphine	11,19	nerve_growth_factor	58,77	morphine	nerve growth factor	MESH:D009020	310738(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of morphine on oedema and tissue concentration of nerve_growth_factor in experimental inflammation of the rat paw .
19103210	0	morphine	75,83	nerve_growth_factor	13,32	morphine	nerve growth factor	MESH:D009020	310738(Tax:10116)	Chemical	Gene	analgesia|amod|START_ENTITY enhancement|nmod|analgesia roles|nmod|enhancement roles|nmod|END_ENTITY	The roles of nerve_growth_factor and cholecystokinin in the enhancement of morphine analgesia in a rodent model of central_nervous_system_inflammation .
10495011	0	morphine	91,99	neuropeptide_Y	11,25	morphine	neuropeptide Y	MESH:D009020	24604(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of neuropeptide_Y on the discriminative stimulus and antinociceptive properties of morphine .
19556004	0	morphine	80,88	neuropeptide_Y	15,29	morphine	neuropeptide Y	MESH:D009020	24604(Tax:10116)	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of neuropeptide_Y in the acute , chronic and withdrawal responses of morphine in nociception in neuropathic_rats : behavioral and neuroanatomical correlates .
18706409	0	morphine	119,127	neurotensin	34,45	morphine	neurotensin	MESH:D009020	299757(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nmod|effect	Evidence for a role of endogenous neurotensin in the development of sensitization to the locomotor stimulant effect of morphine .
9262357	0	morphine	178,186	neurotensin	111,122	morphine	neurotensin	MESH:D009020	299757(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY influence|nmod|effect antagonist|dep|influence antagonist|compound|END_ENTITY	Dose-dependent pain-facilitatory and - inhibitory actions of neurotensin are revealed by SR_48692 , a nonpeptide neurotensin antagonist : influence on the antinociceptive effect of morphine .
9262357	0	morphine	178,186	neurotensin	60,71	morphine	neurotensin	MESH:D009020	299757(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY influence|nmod|effect antagonist|dep|influence SR_48692|appos|antagonist revealed|nmod|SR_48692 revealed|nsubjpass|pain-facilitatory pain-facilitatory|nmod|END_ENTITY	Dose-dependent pain-facilitatory and - inhibitory actions of neurotensin are revealed by SR_48692 , a nonpeptide neurotensin antagonist : influence on the antinociceptive effect of morphine .
10203325	0	morphine	73,81	nociceptin	46,56	morphine	nociceptin	MESH:D009020	25516(Tax:10116)	Chemical	Gene	analgesia|amod|START_ENTITY antagonizing|dobj|analgesia reverses|advcl|antagonizing reverses|dobj|effect effect|nmod|END_ENTITY	Nocistatin reverses the effect of orphanin_FQ / nociceptin in antagonizing morphine analgesia .
10998546	0	morphine	85,93	nociceptin	105,115	morphine	nociceptin	MESH:D009020	25516(Tax:10116)	Chemical	Gene	actions|amod|START_ENTITY prevention|nmod|actions oligonucleotide|nmod|prevention oligonucleotide|nmod|END_ENTITY	Effects of an antisense oligonucleotide to pronociceptin and long-term prevention of morphine actions by nociceptin .
1483291	0	morphine	14,22	oxytocin	61,69	morphine	oxytocin	MESH:D009020	5020	Chemical	Gene	administration|amod|START_ENTITY effect|nmod|administration effect|nmod|concentrations concentrations|compound|END_ENTITY	The effect of morphine and naloxone administration on plasma oxytocin concentrations in the first stage of labour .
3033220	0	morphine	46,54	oxytocin	86,94	morphine	oxytocin	MESH:D009020	18429(Tax:10090)	Chemical	Gene	tolerance|compound|START_ENTITY peptides|nmod|tolerance Effects|nmod|peptides Effects|dep|actions actions|nmod|END_ENTITY	Effects of oxytocin-related peptides on acute morphine tolerance : opposite actions by oxytocin and its receptor antagonists .
6633948	0	morphine	34,42	oxytocin	61,69	morphine	oxytocin	MESH:D009020	5020	Chemical	Gene	action|nmod|START_ENTITY action|nmod|END_ENTITY	Differential inhibitory action by morphine on the release of oxytocin and vasopressin from the isolated neural lobe .
16403466	0	morphine	80,88	p38_mitogen-activated_protein_kinase	14,50	morphine	p38 mitogen-activated protein kinase	MESH:D009020	81649(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Activation Activation|nmod|END_ENTITY	Activation of p38_mitogen-activated_protein_kinase in spinal microglia mediates morphine antinociceptive tolerance .
6350811	0	morphine	21,29	pancreatic_polypeptide	37,59	morphine	pancreatic polypeptide	MESH:D009020	5539	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|response response|amod|END_ENTITY	Suppressor effect of morphine on the pancreatic_polypeptide response to insulin-induced hypoglycemia in man .
12706255	0	morphine	88,96	phospholipase_C_gamma_1	38,61	morphine	phospholipase C gamma 1	MESH:D009020	18803(Tax:10090)	Chemical	Gene	treatment|nmod|START_ENTITY END_ENTITY|nmod|treatment	Direct evidence for the activation of phospholipase_C_gamma_1 by in vivo treatment with morphine in the mouse periaqueductal gray matter .
10095091	0	morphine	19,27	preprodynorphin	38,53	morphine	preprodynorphin	MESH:D009020	29190(Tax:10116)	Chemical	Gene	increases|compound|START_ENTITY increases|amod|END_ENTITY	Acute intermittent morphine increases preprodynorphin and kappa opioid receptor mRNA levels in the rat brain .
19723567	0	morphine	106,114	pro-opiomelanocortin	41,61	morphine	pro-opiomelanocortin	MESH:D009020	18976(Tax:10090)	Chemical	Gene	development|compound|START_ENTITY involvement|nmod|development involvement|nmod|gene gene|amod|END_ENTITY	Possible involvement of the hypothalamic pro-opiomelanocortin gene and beta-endorphin expression on acute morphine withdrawal development .
2144463	0	morphine	11,19	pro-opiomelanocortin	33,53	morphine	pro-opiomelanocortin	MESH:D009020	24664(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY Effects|nmod|treatment Effects|nmod|systems systems|amod|END_ENTITY	Effects of morphine treatment on pro-opiomelanocortin systems in rat brain .
4000418	0	morphine	51,59	pro-opiomelanocortin	63,83	morphine	pro-opiomelanocortin	MESH:D009020	24664(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	Differential alterations by chronic treatment with morphine of pro-opiomelanocortin mRNA levels in anterior as compared to intermediate pituitary lobes of rats .
9574833	0	morphine	31,39	prodynorphin	62,74	morphine	prodynorphin	MESH:D009020	18610(Tax:10090)	Chemical	Gene	administration|amod|START_ENTITY administration|nmod|expression expression|compound|proenkephalin proenkephalin|compound|END_ENTITY	Effects of single and repeated morphine administration on the prodynorphin , proenkephalin and dopamine_D2_receptor gene expression in the mouse brain .
9227847	0	morphine	10,18	proenkephalin	22,35	morphine	proenkephalin	MESH:D009020	29237(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of morphine on proenkephalin gene expression in the rat brain .
12916821	0	morphine	14,22	prolactin	54,63	morphine	prolactin	MESH:D009020	280901(Tax:9913)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|release release|nmod|END_ENTITY	The effect of morphine and naloxone on the release of prolactin during machine milking in dairy cows .
15740787	0	morphine	8,16	prolactin	62,71	morphine	prolactin	MESH:D009020	24683(Tax:10116)	Chemical	Gene	exposure|compound|START_ENTITY decreases|nsubj|exposure decreases|dobj|secretion secretion|compound|END_ENTITY	Chronic morphine exposure during puberty decreases postpartum prolactin secretion in adult female rats .
2384365	0	morphine	85,93	prolactin	6,15	morphine	prolactin	MESH:D009020	5617	Chemical	Gene	administration|compound|START_ENTITY naloxone|dobj|administration Serum|xcomp|naloxone Serum|dobj|responses responses|compound|END_ENTITY	Serum prolactin and growth_hormone responses to naloxone and intracerebral ventricle morphine administration in heifers .
2716955	0	morphine	10,18	prolactin	42,51	morphine	prolactin	MESH:D009020	443317(Tax:9940)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|concentrations concentrations|compound|END_ENTITY	Effect of morphine and naloxone on plasma prolactin concentrations in the fetal sheep and pregnant ewe during late gestation .
3386414	0	morphine	57,65	prolactin	36,45	morphine	prolactin	MESH:D009020	24683(Tax:10116)	Chemical	Gene	release|xcomp|START_ENTITY release|nsubj|course course|nmod|insensitivity insensitivity|nmod|END_ENTITY	Time course of the insensitivity of prolactin release to morphine administration in the lactating female rat .
3430186	0	morphine	17,25	prolactin	90,99	morphine	prolactin	MESH:D009020	5617	Chemical	Gene	produces|nsubj|START_ENTITY produces|dobj|END_ENTITY	Intraventricular morphine produces pain relief , hypothermia , hyperglycaemia and increased prolactin and growth_hormone levels in patients with cancer_pain .
3587524	0	morphine	75,83	prolactin	10,19	morphine	prolactin	MESH:D009020	5617	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of prolactin on tolerance and dependence to acute administration of morphine .
3950867	0	morphine	114,122	prolactin	77,86	morphine	prolactin	MESH:D009020	24683(Tax:10116)	Chemical	Gene	administration|amod|START_ENTITY dopamine|nmod|administration dopamine|dobj|neurons neurons|nmod|secretion secretion|compound|END_ENTITY	Delayed activation of tuberoinfundibular dopamine neurons and suppression of prolactin secretion in the rat after morphine administration .
503252	0	morphine	71,79	prolactin	42,51	morphine	prolactin	MESH:D009020	24683(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Inhibition Inhibition|nmod|agonists agonists|nmod|release release|compound|END_ENTITY	Inhibition by cholinergic agonists of the prolactin release induced by morphine .
6290924	0	morphine	54,62	prolactin	11,20	morphine	prolactin	MESH:D009020	24683(Tax:10116)	Chemical	Gene	nucleus|amod|START_ENTITY Release|nmod|nucleus Release|nmod|END_ENTITY	Release of prolactin in response to microinjection of morphine into mesencephalic dorsal raphe nucleus .
6306374	0	morphine	75,83	prolactin	52,61	morphine	prolactin	MESH:D009020	24683(Tax:10116)	Chemical	Gene	induced|xcomp|START_ENTITY induced|dobj|responsiveness responsiveness|nmod|secretion secretion|compound|END_ENTITY	Long-term ACTH induced diminished responsiveness of prolactin secretion to morphine .
6335081	0	morphine	70,78	prolactin	12,21	morphine	prolactin	MESH:D009020	24683(Tax:10116)	Chemical	Gene	secretion|xcomp|START_ENTITY secretion|nsubj|Response Response|nmod|END_ENTITY	Response of prolactin , growth_hormone and corticosterone secretion to morphine administration or stress exposure in Wistar-AVN and Long Evans rats .
6354944	0	morphine	130,138	prolactin	51,60	morphine	prolactin	MESH:D009020	5617	Chemical	Gene	Effect|dep|START_ENTITY Effect|nmod|indoprofen indoprofen|nmod|END_ENTITY	Effect of i.v. indoprofen on cancer_pain and serum prolactin and growth_hormone levels -- a controlled pharmacologic study vs i. m. morphine and placebo .
6800848	3	morphine	497,505	prolactin	562,571	morphine	prolactin	MESH:D009020	5617	Chemical	Gene	affect|nsubj|START_ENTITY affect|dobj|neurotransmitter neurotransmitter|acl:relcl|controls controls|dobj|END_ENTITY	It is suggested that morphine may affect a common neurotransmitter that controls both prolactin and LH secretion .
7201058	0	morphine	11,19	prolactin	60,69	morphine	prolactin	MESH:D009020	24683(Tax:10116)	Chemical	Gene	dependence|amod|START_ENTITY Effects|nmod|dependence Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of morphine dependence , withdrawal and tolerance on prolactin and growth_hormone secretion in the rat .
745306	0	morphine	11,19	prolactin	33,42	morphine	prolactin	MESH:D009020	24683(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|compound|END_ENTITY	Effects of morphine on the serum prolactin levels of morphine-tolerant and nontolerant male rats and of the in vitro release of pituitary prolactin .
8680424	0	morphine	11,19	prolactin	36,45	morphine	prolactin	MESH:D009020	24683(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of morphine and naloxone on prolactin and growth_hormone gene expression in the male rat pituitary gland .
9080251	0	morphine	90,98	prolactin	8,17	morphine	prolactin	MESH:D009020	5617	Chemical	Gene	administration|compound|START_ENTITY cell|nmod|administration cell|nsubj|Role Role|nmod|END_ENTITY	Role of prolactin in the modulation of NK and LAK cell activity after short - or long-term morphine administration in neoplastic patients .
15140157	0	morphine	159,167	proopiomelanocortin	14,33	morphine	proopiomelanocortin	MESH:D009020	24664(Tax:10116)	Chemical	Gene	treated|nmod|START_ENTITY rats|acl|treated altered|nmod|rats altered|nsubjpass|Expression Expression|nmod|mRNA mRNA|compound|END_ENTITY	Expression of proopiomelanocortin and proenkephalin mRNA in sexually dimorphic brain regions are altered in adult male and female rats treated prenatally with morphine .
8883945	0	morphine	10,18	proopiomelanocortin	22,41	morphine	proopiomelanocortin	MESH:D009020	24664(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of morphine on proopiomelanocortin gene expression and peptide levels in the hypothalamus .
7667370	0	morphine	52,60	secretin	11,19	morphine	secretin	MESH:D009020	20287(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of secretin on acute and chronic effects of morphine .
2124334	0	morphine	117,125	thyrotropin_releasing_hormone	10,39	morphine	thyrotropin releasing hormone	MESH:D009020	25569(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of thyrotropin_releasing_hormone on the development of tolerance to the analgesic and hyperthermic actions of morphine in the rat .
2516632	0	morphine	95,103	thyrotropin_releasing_hormone	29,58	morphine	thyrotropin releasing hormone	MESH:D009020	25569(Tax:10116)	Chemical	Gene	tolerant-dependent|amod|START_ENTITY membranes|nmod|tolerant-dependent END_ENTITY|nmod|membranes	The binding of 3H - -LRB- 3-MeHis2 -RRB- thyrotropin_releasing_hormone to brain and pituitary membranes of morphine tolerant-dependent and abstinent rats .
2996045	0	morphine	76,84	thyrotropin_releasing_hormone	23,52	morphine	thyrotropin releasing hormone	MESH:D009020	22044(Tax:10090)	Chemical	Gene	abstinence_syndrome|amod|START_ENTITY effects|nmod|abstinence_syndrome effects|nmod|END_ENTITY	Comparative effects of thyrotropin_releasing_hormone , MK-771 and DN-1417 on morphine abstinence_syndrome .
6409194	0	morphine	85,93	thyrotropin_releasing_hormone	30,59	morphine	thyrotropin releasing hormone	MESH:D009020	22044(Tax:10090)	Chemical	Gene	comparison|nmod|START_ENTITY properties|dep|comparison properties|nmod|END_ENTITY	Antinociceptive properties of thyrotropin_releasing_hormone in mice : comparison with morphine .
7519178	0	morphine	21,29	tumor_necrosis_factor	60,81	morphine	tumor necrosis factor	MESH:D009020	7124	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Inhibitory effect of morphine on granulocyte stimulation by tumor_necrosis_factor and substance_P .
14975222	0	morphine	11,19	tumor_necrosis_factor-alpha	36,63	morphine	tumor necrosis factor-alpha	MESH:D009020	7124	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|concentrations concentrations|amod|END_ENTITY	Effects of morphine and fentanyl on tumor_necrosis_factor-alpha and interleukin-6 concentrations in human whole blood in vitro .
19111113	0	morphine	41,49	tumor_necrosis_factor-alpha	85,112	morphine	tumor necrosis factor-alpha	MESH:D009020	24835(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of epidurally administration of morphine at thoracic level on expression of tumor_necrosis_factor-alpha in the lungs in acute myocardial_ischemia in rats -RSB- .
9058753	0	morphine	10,18	tumor_necrosis_factor-alpha	49,76	morphine	tumor necrosis factor-alpha	MESH:D009020	21926(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Effect of morphine on lipopolysaccharide-induced tumor_necrosis_factor-alpha production in vivo : involvement of the sympathetic nervous system .
28112	0	morphine	85,93	tyrosine_aminotransferase	17,42	morphine	tyrosine aminotransferase	MESH:D009020	24813(Tax:10116)	Chemical	Gene	administration|nmod|START_ENTITY END_ENTITY|nmod|administration	Changes in liver tyrosine_aminotransferase after acute and chronic administration of morphine in the rat .
17216288	0	morphine	184,192	tyrosine_hydroxylase	116,136	morphine	tyrosine hydroxylase	MESH:D009020	25085(Tax:10116)	Chemical	Gene	withdrawal|compound|START_ENTITY heart|nmod|withdrawal expression|nmod|heart expression|amod|END_ENTITY	Differential involvement of 3 ' , 5 ' - cyclic_adenosine_monophosphate-dependent protein kinase in regulation of Fos and tyrosine_hydroxylase expression in the heart after naloxone induced morphine withdrawal .
19179436	0	morphine	183,191	tyrosine_hydroxylase	64,84	morphine	tyrosine hydroxylase	MESH:D009020	25085(Tax:10116)	Chemical	Gene	withdrawal|amod|START_ENTITY responsible|nmod|withdrawal responsible|nmod|induction induction|nmod|expression expression|amod|END_ENTITY	Elevated glucocorticoid levels are responsible for induction of tyrosine_hydroxylase mRNA expression , phosphorylation , and enzyme activity in the nucleus of the solitary tract during morphine withdrawal .
7516996	0	morphine	10,18	tyrosine_hydroxylase	35,55	morphine	tyrosine hydroxylase	MESH:D009020	7054	Chemical	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	Effect of morphine on hypothalamic tyrosine_hydroxylase mRNA levels in dopaminergic neurons and on preoptic DOPAC levels measured by microdialysis .
22898544	0	morphine-3-glucuronide	27,49	Toll-like_receptor_4	67,87	morphine-3-glucuronide	Toll-like receptor 4	MESH:C018108	21898(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY dependent|nsubj|effects dependent|nmod|END_ENTITY	Neuroexcitatory effects of morphine-3-glucuronide are dependent on Toll-like_receptor_4 signaling .
26879314	0	morpholin-3-one	6,21	EGFR	55,59	morpholin-3-one	EGFR	null	1956	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Novel morpholin-3-one fused quinazoline derivatives as EGFR tyrosine kinase inhibitors .
9804700	0	morpholine	193,203	NK-1_receptor	217,230	morpholine	NK-1 receptor	MESH:C037574	6869	Chemical	Gene	antagonist|compound|START_ENTITY antagonist|compound|END_ENTITY	Structural optimization affording 2 - -LRB- R -RRB- - -LRB- 1 - -LRB- R -RRB- -3 , _ 5-bis -LRB- trifluoromethyl -RRB- phenylethoxy -RRB- -3 - -LRB- S -RRB- - -LRB- 4-fluoro -RRB- phenyl-4 - _ -LRB- 3-oxo-1 ,2,4 - triazol-5-yl -RRB- methylmorpholine , a potent , orally active , long-acting morpholine acetal human NK-1_receptor antagonist .
15236446	0	morpholine	72,82	substance_P	90,101	morpholine	substance P	MESH:C037574	6863	Chemical	Gene	antagonist|amod|START_ENTITY antagonist|compound|END_ENTITY	Novel rearrangements of an N-oxide degradate formed from oxidation of a morpholine acetal substance_P antagonist .
5547764	0	morphone	11,19	choline_acetyltransferase	23,48	morphone	choline acetyltransferase	null	290567(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|amod|END_ENTITY	Effects of morphone on choline_acetyltransferase levels in the caudate nucleus of the rat .
25953268	0	morroniside	22,33	CYP3A	13,18	morroniside	CYP3A	MESH:C488401	170509(Tax:10116)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of CYP3A by morroniside in rats .
25754021	0	morroniside	105,116	Protein_kinase_B	0,16	morroniside	Protein kinase B	MESH:C488401	2185	Chemical	Gene	effect|nmod|START_ENTITY contribute|nmod|effect contribute|nsubj|END_ENTITY	Protein_kinase_B and extracellular_signal-regulated_kinase contribute to the chondroprotective effect of morroniside on osteoarthritis chondrocytes .
20060191	0	mosapride	14,23	5HT-4	25,30	mosapride	5HT-4	MESH:C062720	3360	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|agonist agonist|nummod|END_ENTITY	The effect of mosapride -LRB- 5HT-4 receptor agonist -RRB- on insulin sensitivity and GLUT4 translocation .
11558572	0	mosapride_citrate	11,28	motilin	55,62	mosapride citrate	motilin	MESH:C062720	4295	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of mosapride_citrate on human plasma levels of motilin , gastrin , somatostatin , and secretin .
22608202	0	mosodium_urate	29,43	Serum_amyloid_A	0,15	mosodium urate	Serum amyloid A	null	6287	Chemical	Gene	triggers|dobj|START_ENTITY triggers|nsubj|END_ENTITY	Serum_amyloid_A triggers the mosodium_urate - mediated mature interleukin-1b production from human synovial fibroblasts .
15003292	0	motoneurones	49,61	pro-opiomelanocortin	20,40	motoneurones	pro-opiomelanocortin	null	18976(Tax:10090)	Chemical	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Upregulation of the pro-opiomelanocortin gene in motoneurones after acrylamide administration in mice .
24777102	0	moxalactam	107,117	Mox-1	21,26	moxalactam	Mox-1	MESH:D009070	4222	Chemical	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Crystal structure of Mox-1 , a unique plasmid-mediated class C b-lactamase with hydrolytic activity towards moxalactam .
16352735	0	moxifloxacin	29,41	IL-1beta	51,59	moxifloxacin	IL-1beta	MESH:C104727	3553	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|secretion secretion|compound|END_ENTITY	Anti-inflammatory effects of moxifloxacin on IL-8 , IL-1beta and TNF-alpha secretion and NFkappaB and MAP-kinase activation in human monocytes stimulated with Aspergillus_fumigatus .
25519764	0	moxifloxacin_hydrochloride	66,92	hPON1	27,32	moxifloxacin hydrochloride	hPON1	MESH:C104727	5444	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|dep|effects	Human serum paraoxonase-1 -LRB- hPON1 -RRB- : in vitro inhibition effects of moxifloxacin_hydrochloride , levofloxacin_hemihidrate , cefepime_hydrochloride , cefotaxime_sodium and ceftizoxime_sodium .
20139920	0	moxonidine	10,20	YKL-40	45,51	moxonidine	YKL-40	MESH:C043482	1116	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of moxonidine and amlodipine on serum YKL-40 , plasma lipids and insulin sensitivity in insulin-resistant hypertensive patients-a randomized , crossover trial .
18230271	0	moxonidine	38,48	adiponectin	58,69	moxonidine	adiponectin	MESH:C043482	9370	Chemical	Gene	therapy|nmod|START_ENTITY Effects|nmod|therapy Effects|nmod|levels levels|compound|END_ENTITY	Effects of sympatholytic therapy with moxonidine on serum adiponectin levels in hypertensive women .
15061081	0	multicopper	39,50	Ferroxidase	0,11	multicopper	Ferroxidase	null	851437(Tax:4932)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Ferroxidase activity in a laccase-like multicopper oxidase from Liriodendron_tulipifera .
12684851	0	multicopper	79,90	ferroxidase	28,39	multicopper	ferroxidase	null	851437(Tax:4932)	Chemical	Gene	suppression|nmod|START_ENTITY suppression|nmod|END_ENTITY	Targeted suppression of the ferroxidase and iron trafficking activities of the multicopper oxidase Fet3p from Saccharomyces_cerevisiae .
10515450	0	multiplane	15,25	vascular_endothelial_growth_factor	106,140	multiplane	vascular endothelial growth factor	null	7422	Chemical	Gene	START_ENTITY|nmod|transfer transfer|nmod|END_ENTITY	Intraoperative multiplane transesophageal echocardiography for guiding direct myocardial gene transfer of vascular_endothelial_growth_factor in patients with refractory_angina_pectoris .
20980265	0	multivitamin	86,98	hSMVT	112,117	multivitamin	hSMVT	null	8884	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Surprising substrate versatility in SLC5A6 : Na + - coupled I - transport by the human Na + / multivitamin transporter -LRB- hSMVT -RRB- .
19074414	0	mumbaistatin	114,126	G6PT	104,108	mumbaistatin	G6PT	MESH:C430985	2538	Chemical	Gene	analogs|compound|START_ENTITY END_ENTITY|nmod|analogs	Evidence for transcriptional regulation of the glucose-6-phosphate_transporter by HIF-1alpha : Targeting G6PT with mumbaistatin analogs in hypoxic mesenchymal stromal cells .
12514169	0	muramyl_dipeptide	30,47	NOD2	65,69	muramyl dipeptide	NOD2	MESH:D000119	64127	Chemical	Gene	recognition|nmod|START_ENTITY mediated|nsubj|recognition mediated|nmod|END_ENTITY	Host recognition of bacterial muramyl_dipeptide mediated through NOD2 .
21411292	0	muramyl_dipeptide	26,43	NOD2	12,16	muramyl dipeptide	NOD2	MESH:D000119	64127	Chemical	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	A synthetic NOD2 agonist , muramyl_dipeptide -LRB- MDP -RRB- - Lys -LRB- L18 -RRB- and IFN-b synergistically induce dendritic cell maturation with augmented IL-12 production and suppress melanoma growth .
22549783	0	muramyl_dipeptide	123,140	NOD2	84,88	muramyl dipeptide	NOD2	MESH:D000119	64127	Chemical	Gene	direct|nmod|START_ENTITY mediated|nmod|direct mediated|nsubjpass|Pathogen Pathogen|acl|sensing sensing|nmod|nucleotide-binding_oligomerization_domain-containing_protein_2 nucleotide-binding_oligomerization_domain-containing_protein_2|appos|END_ENTITY	Pathogen sensing by nucleotide-binding_oligomerization_domain-containing_protein_2 -LRB- NOD2 -RRB- is mediated by direct binding to muramyl_dipeptide and ATP .
23255217	0	muramyl_dipeptide	23,40	NOD2	65,69	muramyl dipeptide	NOD2	MESH:D000119	291912(Tax:10116)	Chemical	Gene	Identification|appos|START_ENTITY Identification|dep|domains domains|nmod|receptor receptor|compound|END_ENTITY	Identification of MDP -LRB- muramyl_dipeptide -RRB- - binding key domains in NOD2 -LRB- nucleotide-binding and oligomerization domain-2 -RRB- receptor of Labeo_rohita .
23709157	0	muramyl_dipeptide	22,39	NOD2	0,4	muramyl dipeptide	NOD2	MESH:D000119	64127	Chemical	Gene	stimulation|amod|START_ENTITY affect|dobj|stimulation affect|nsubj|mutations mutations|compound|END_ENTITY	NOD2 mutations affect muramyl_dipeptide stimulation of human B lymphocytes and interact with other IBD-associated genes .
24695226	10	muramyl_dipeptide	1668,1685	NOD2	1648,1652	muramyl dipeptide	NOD2	MESH:D000119	64127	Chemical	Gene	START_ENTITY|amod|bacterially bacterially|dep|components components|nmod|cognate cognate|compound|END_ENTITY	The transporters mediate the egress of bacterially derived components , such as the NOD2 cognate ligand muramyl_dipeptide -LRB- MDP -RRB- , and are selectively required for NOD2 responses to endosomally derived MDP .
18322214	0	muramyl_dipeptide	46,63	Nod2	130,134	muramyl dipeptide	Nod2	MESH:D000119	64127	Chemical	Gene	delivery|nmod|START_ENTITY induces|nsubj|delivery induces|dobj|activation activation|nmod|independently independently|nmod|END_ENTITY	Pannexin-1-mediated intracellular delivery of muramyl_dipeptide induces caspase-1 activation via cryopyrin/NLRP3 independently of Nod2 .
2074443	0	muramyl_dipeptide	38,55	tumor_necrosis_factor	83,104	muramyl dipeptide	tumor necrosis factor	MESH:D000119	21926(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Priming effect of orally administered muramyl_dipeptide on induction of endogenous tumor_necrosis_factor .
10528411	0	muristeroneA	104,116	ecdysone_receptor	75,92	muristeroneA	ecdysone receptor	MESH:C055348	35540(Tax:7227)	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Transcriptional activation of the cloned Heliothis virescens -LRB- Lepidoptera -RRB- ecdysone_receptor -LRB- HvEcR -RRB- by muristeroneA .
17353094	0	muscimol	30,38	GABAA	16,21	muscimol	GABAA	MESH:D009118	14405(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|agonist agonist|compound|END_ENTITY	The effect of a GABAA agonist muscimol on acoustic_injury of the mouse cochlea .
162520	0	muscimol	57,65	prolactin	15,24	muscimol	prolactin	MESH:D009118	5617	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Stimulation Stimulation|nmod|END_ENTITY	Stimulation of prolactin and growth_hormone secretion by muscimol , a gamma-aminobutyric_acid agonist .
3689452	0	muscone	71,78	cytochrome_P-450	13,29	muscone	cytochrome P-450	MESH:C031021	25251(Tax:10116)	Chemical	Gene	activities|nmod|START_ENTITY activities|amod|END_ENTITY	Induction of cytochrome_P-450 and related drug-oxidizing activities in muscone -LRB- 3-methylcyclopentadecanone -RRB- - treated rats .
6732849	0	muzolimine	13,23	elastin	41,48	muzolimine	elastin	MESH:D009156	25043(Tax:10116)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of muzolimine on arterial wall elastin .
11338837	0	mycocin	31,38	Y-2838	67,73	mycocin	Y-2838	null	1147786(Tax:187410)	Chemical	Gene	START_ENTITY|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Specificity of sensitivity to mycocin from Tilletiopsis flava BKM Y-2838 -RSB- .
24460726	0	mycophenolate_mofetil	108,129	CCL2	18,22	mycophenolate mofetil	CCL2	MESH:C063008	6347	Chemical	Gene	levels|nmod|START_ENTITY levels|nmod|END_ENTITY	Reduced levels of CCL2 and CXCL10 in systemic_lupus_erythematosus patients under treatment with prednisone , mycophenolate_mofetil , or hydroxychloroquine , except in a high STAT1 subset .
18460000	0	mycophenolate_mofetil	51,72	Calcineurin_inhibitor	0,21	mycophenolate mofetil	Calcineurin inhibitor	MESH:C063008	23523	Chemical	Gene	withdrawal|nmod|START_ENTITY withdrawal|compound|END_ENTITY	Calcineurin_inhibitor withdrawal and conversion to mycophenolate_mofetil and steroids in cardiac transplant recipients with chronic_renal_failure : a word of caution .
16830106	0	mycophenolate_mofetil	86,107	angiotensin_converting_enzyme	41,70	mycophenolate mofetil	angiotensin converting enzyme	MESH:C063008	24310(Tax:10116)	Chemical	Gene	inhibitor|nmod|START_ENTITY inhibitor|amod|END_ENTITY	Renoprotective effects of combination of angiotensin_converting_enzyme inhibitor with mycophenolate_mofetil in diabetic rats .
22306450	0	mycophenolate_mofetil	62,83	b-cyclodextrin	42,56	mycophenolate mofetil	b-cyclodextrin	MESH:C063008	285440	Chemical	Gene	Investigation|nmod|START_ENTITY Investigation|nmod|END_ENTITY	Investigation of the inclusion complex of b-cyclodextrin with mycophenolate_mofetil .
19715976	0	mycophenolate_mofetil	9,30	calcineurin_inhibitor	48,69	mycophenolate mofetil	calcineurin inhibitor	MESH:C063008	23523	Chemical	Gene	therapy|amod|START_ENTITY therapy|compound|END_ENTITY	Combined mycophenolate_mofetil and minimal dose calcineurin_inhibitor therapy in liver transplant patients : clinical results of a prospective randomized study .
11482341	0	mycophenolate_mofetil	9,30	cyclosporin_A	59,72	mycophenolate mofetil	cyclosporin A	MESH:C063008	1161	Chemical	Gene	START_ENTITY|nmod|comparison comparison|nmod|END_ENTITY	Systemic mycophenolate_mofetil in comparison with systemic cyclosporin_A in high-risk keratoplasty patients : 3 years ' results of a randomized prospective clinical trial .
18937726	0	mycophenolate_mofetil	44,65	factor_VIII	99,110	mycophenolate mofetil	factor VIII	MESH:C063008	2157	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	A case report of plasma exchange , steroids , mycophenolate_mofetil and cyclophosphamide in acquired factor_VIII inhibitors .
24969967	0	mycophenolate_mofetil	24,45	interleukin-2	136,149	mycophenolate mofetil	interleukin-2	MESH:C063008	3558	Chemical	Gene	effects|nmod|START_ENTITY activated|nsubj|effects activated|nmod|END_ENTITY	Differential effects of mycophenolate_mofetil and cyclosporine_A on peripheral blood and cord blood natural killer cells activated with interleukin-2 .
24782172	0	mycophenolate_mofetil	11,32	monocyte_chemoattractant_protein-1	54,88	mycophenolate mofetil	monocyte chemoattractant protein-1	MESH:C063008	6347	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effects of mycophenolate_mofetil on the expression of monocyte_chemoattractant_protein-1 and fibronectin in high glucose cultured human mesangial cells .
20455882	0	mycophenolic_acid	44,61	CsA	33,36	mycophenolic acid	CsA	MESH:D009173	1161	Chemical	Gene	START_ENTITY|nsubj|versus versus|compound|END_ENTITY	Everolimus plus reduced-exposure CsA versus mycophenolic_acid plus standard-exposure CsA in renal-transplant recipients .
14671038	0	mycophenolic_acid	11,28	IL-6	32,36	mycophenolic acid	IL-6	MESH:D009173	3569	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effects of mycophenolic_acid on IL-6 expression of human renal proximal and distal tubular cells in vitro .
12100761	0	mycophenolic_acid	14,31	NF-kappaB	35,44	mycophenolic acid	NF-kappaB	MESH:D009173	4790	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Inhibition of mycophenolic_acid on NF-kappaB activity in human endothelial cells .
15258099	0	mycophenolic_acid	53,70	UGT1A9	17,23	mycophenolic acid	UGT1A9	MESH:D009173	54600	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The main role of UGT1A9 in the hepatic metabolism of mycophenolic_acid and the effects of naturally occurring variants .
11733621	0	mycophenolic_acid	68,85	endothelin-1	89,101	mycophenolic acid	endothelin-1	MESH:D009173	1906	Chemical	Gene	START_ENTITY|nmod|synthesis synthesis|amod|END_ENTITY	Influence of hepatocyte_growth_factor , epidermal growth factor , and mycophenolic_acid on endothelin-1 synthesis in human endothelial cells .
26126806	0	mycophenolic_acid	22,39	mTOR	0,4	mycophenolic acid	mTOR	MESH:D009173	21977(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|versus versus|compound|END_ENTITY	mTOR inhibitor versus mycophenolic_acid as the primary immunosuppression regime combined with calcineurin_inhibitor for kidney transplant recipients : a meta-analysis .
20973683	0	mycophenolic_acid	139,156	multidrug_resistance-associated_protein_2	76,117	mycophenolic acid	multidrug resistance-associated protein 2	MESH:D009173	1244	Chemical	Gene	pathway|nmod|START_ENTITY pathway|amod|END_ENTITY	Pharmacogenetic impact of UDP-glucuronosyltransferase metabolic pathway and multidrug_resistance-associated_protein_2 transport pathway on mycophenolic_acid in thoracic transplant recipients : an exploratory study .
14978191	0	mycophenolic_acid_glucuronide	69,98	multidrug_resistance-associated_protein_2	120,161	mycophenolic acid glucuronide	multidrug resistance-associated protein 2	MESH:C113145	25303(Tax:10116)	Chemical	Gene	START_ENTITY|acl|mediated mediated|nmod|END_ENTITY	Cyclosporin_A , but not tacrolimus , inhibits the biliary excretion of mycophenolic_acid_glucuronide possibly mediated by multidrug_resistance-associated_protein_2 in rats .
12930994	0	mycothiol	21,30	Rv0819	41,47	mycothiol	Rv0819	MESH:C089265	885251(Tax:83332)	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	Crystal structure of mycothiol synthase -LRB- Rv0819 -RRB- from Mycobacterium_tuberculosis shows structural homology to the GNAT family of N-acetyltransferases .
20800640	0	myo-inositol	50,62	IMPA2	82,87	myo-inositol	IMPA2	MESH:D007294	3613	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association analysis between polymorphisms in the myo-inositol monophosphatase 2 -LRB- IMPA2 -RRB- gene and bipolar_disorder .
10773690	0	myo-inositol	113,125	SLC5A3	141,147	myo-inositol	SLC5A3	MESH:D007294	6526	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Murine chromosome 16 telomeric region , homologous with human chromosome 21q22 , contains the osmoregulatory Na -LRB- + -RRB- / myo-inositol cotransporter -LRB- SLC5A3 -RRB- gene .
7789985	0	myo-inositol	29,41	SLC5A3	62,68	myo-inositol	SLC5A3	MESH:D007294	6526	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The human osmoregulatory Na + / myo-inositol cotransporter gene -LRB- SLC5A3 -RRB- : molecular cloning and localization to chromosome 21 .
8646889	0	myo-inositol	90,102	SLC5A3	118,124	myo-inositol	SLC5A3	MESH:D007294	6526	Chemical	Gene	cotransporter|amod|START_ENTITY sequence|nmod|cotransporter sequence|appos|END_ENTITY	The 21q22 .1 STS marker , VN02 -LRB- EST00541 cDNA -RRB- , is part of the 3 ' sequence of the human Na + / myo-inositol cotransporter -LRB- SLC5A3 -RRB- gene .
9441750	0	myo-inositol	45,57	SLC5A3	73,79	myo-inositol	SLC5A3	MESH:D007294	6526	Chemical	Gene	cotransporter|amod|START_ENTITY cotransporter|appos|END_ENTITY	The structural organization of the human Na + / myo-inositol cotransporter -LRB- SLC5A3 -RRB- gene and characterization of the promoter .
17932225	0	myo-inositol	19,31	SMIT2	0,5	myo-inositol	SMIT2	MESH:D007294	252854(Tax:10116)	Chemical	Gene	uptake|amod|START_ENTITY mediates|dobj|uptake mediates|nsubj|END_ENTITY	SMIT2 mediates all myo-inositol uptake in apical membranes of rat small intestine .
15464731	0	myo-inositol_1-phosphate	29,53	ISYNA1	64,70	myo-inositol 1-phosphate	ISYNA1	MESH:C002647	51477	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	E2F1 regulation of the human myo-inositol_1-phosphate synthase -LRB- ISYNA1 -RRB- gene promoter .
21841945	0	myo-inositol_3-phosphate	46,70	Isyna1	81,87	myo-inositol 3-phosphate	Isyna1	MESH:C052128	290651(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	Differential methylation of the gene encoding myo-inositol_3-phosphate synthase -LRB- Isyna1 -RRB- in rat tissues .
19336734	0	myoinositol	26,37	Akt	47,50	myoinositol	Akt	MESH:D007294	207	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	The chemopreventive agent myoinositol inhibits Akt and extracellular_signal-regulated_kinase in bronchial lesions from heavy smokers .
3874867	0	myoinositol_trisphosphate	16,41	thrombin	75,83	myoinositol trisphosphate	thrombin	CHEBI:25450	2147	Chemical	Gene	START_ENTITY|nmod|platelets platelets|acl|stimulated stimulated|nmod|END_ENTITY	Mass changes in myoinositol_trisphosphate in human platelets stimulated by thrombin .
23752591	0	myostatin	89,98	SMYD3	22,27	myostatin	SMYD3	MESH:D055435	69726(Tax:10090)	Chemical	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	The methyltransferase SMYD3 mediates the recruitment of transcriptional cofactors at the myostatin and c-Met genes and regulates skeletal muscle_atrophy .
19208403	0	myostatin	14,23	follistatin	41,52	myostatin	follistatin	MESH:D055435	10468	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of myostatin with emphasis on follistatin as a therapy for muscle_disease .
19504174	0	myricetin	27,36	Akt	0,3	myricetin	Akt	MESH:C040015	207	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Akt is a direct target for myricetin to inhibit cell transformation .
24716406	0	myricetin	53,62	COMT	44,48	myricetin	COMT	MESH:C040015	1312	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of catechol-o-methyltransferase -LRB- COMT -RRB- by myricetin , dihydromyricetin , and myricitrin .
10440930	0	myricetin	54,63	NFkappaB	33,41	myricetin	NFkappaB	MESH:C040015	4790	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Suppression of TNFalpha-mediated NFkappaB activity by myricetin and other flavonoids through downregulating the activity of IKK in ECV304 cells .
24716406	0	myricetin	53,62	catechol-o-methyltransferase	14,42	myricetin	catechol-o-methyltransferase	MESH:C040015	1312	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of catechol-o-methyltransferase -LRB- COMT -RRB- by myricetin , dihydromyricetin , and myricitrin .
17958323	0	myricetin	42,51	interleukin-2	14,27	myricetin	interleukin-2	MESH:C040015	16183(Tax:10090)	Chemical	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	Inhibition of interleukin-2 production by myricetin in mouse EL-4 T cells .
19026990	0	myricetin	130,139	vascular_endothelial_growth_factor	81,115	myricetin	vascular endothelial growth factor	MESH:C040015	22339(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	MKK4 is a novel target for the inhibition of tumor_necrosis_factor-alpha-induced vascular_endothelial_growth_factor expression by myricetin .
17678631	0	myricitrin	56,66	p38MAPK	15,22	myricitrin	p38MAPK	MESH:C008577	26416(Tax:10090)	Chemical	Gene	action|nmod|START_ENTITY END_ENTITY|nmod|action	Involvement of p38MAPK on the antinociceptive action of myricitrin in mice .
21849123	0	myriocin	11,19	cyclinD1	41,49	myriocin	cyclinD1	MESH:C001996	58919(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of myriocin on the expression of cyclinD1 in high glucose-induced hypertrophy mesangial cells -RSB- .
8011671	0	myristate	76,85	transferrin_receptor	35,55	myristate	transferrin receptor	MESH:D019814	22042(Tax:10090)	Chemical	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	Posttranslational acylation of the transferrin_receptor in LSTRA cells with myristate , palmitate and stearate : evidence for distinct acyltransferases .
15337832	0	myristic_acid	38,51	3-hydroxy-3-methylglutaryl-CoA_reductase	81,121	myristic acid	3-hydroxy-3-methylglutaryl-CoA reductase	MESH:D019814	3156	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|cells cells|amod|END_ENTITY	Differential translational effects of myristic_acid and eicosapentaenoic_acid on 3-hydroxy-3-methylglutaryl-CoA_reductase from Reuber H35 hepatoma cells .
9168900	0	myristicin	63,73	Cyp1a-1	7,14	myristicin	Cyp1a-1	MESH:C005246	13076(Tax:10090)	Chemical	Gene	induction|nmod|START_ENTITY induction|nsubj|END_ENTITY	Murine Cyp1a-1 induction in mouse hepatoma Hepa-1C1C7 cells by myristicin .
17936244	0	myristoyl	24,33	GCAP-2	71,77	myristoyl	GCAP-2	CHEBI:25456	2979	Chemical	Gene	modification|amod|START_ENTITY modification|nmod|END_ENTITY	Characterization of the myristoyl lipid modification of membrane-bound GCAP-2 by 2H solid-state NMR spectroscopy .
7630423	0	myristoyl	40,49	recoverin	59,68	myristoyl	recoverin	CHEBI:25456	5957	Chemical	Gene	group|amod|START_ENTITY group|nmod|END_ENTITY	Sequestration of the membrane-targeting myristoyl group of recoverin in the calcium-free state .
12654170	0	n-3_fatty_acids	22,37	C-reactive_protein	65,83	n-3 fatty acids	C-reactive protein	MESH:D015525	1401	Chemical	Gene	concentrations|amod|START_ENTITY concentrations|nmod|END_ENTITY	The effect of dietary n-3_fatty_acids on serum concentrations of C-reactive_protein : a dose-response study .
22981383	0	n-3_polyunsaturated_fatty_acids	25,56	fat-1	60,65	n-3 polyunsaturated fatty acids	fat-1	null	14107(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Endogenously synthesized n-3_polyunsaturated_fatty_acids in fat-1 mice ameliorate high-fat diet-induced non-alcoholic_fatty_liver_disease .
20441771	0	n-acetylcholine	49,64	beta2	74,79	n-acetylcholine	beta2	null	10242	Chemical	Gene	subunit|amod|START_ENTITY subunit|amod|END_ENTITY	NMR structure of the transmembrane domain of the n-acetylcholine receptor beta2 subunit .
12404611	0	n-acetylserotonin	54,71	MAO-A	23,28	n-acetylserotonin	MAO-A	MESH:C006389	29253(Tax:10116)	Chemical	Gene	pineal|dobj|START_ENTITY pineal|nsubj|effects effects|nmod|inhibition inhibition|amod|END_ENTITY	Ontogenetic effects of MAO-A inhibition on rat pineal n-acetylserotonin and melatonin during the first month of neonatal life .
25863270	0	n-alkanols	30,40	5-HT3A	52,58	n-alkanols	5-HT3A	null	3359	Chemical	Gene	START_ENTITY|nmod|receptors receptors|amod|END_ENTITY	Fast and slow interactions of n-alkanols with human 5-HT3A receptors : Implications for anesthetic mechanisms .
7092923	0	n-alkyl_carbamates	71,89	cytochrome_P-450	36,52	n-alkyl carbamates	cytochrome P-450	null	25251(Tax:10116)	Chemical	Gene	relationship|nmod|START_ENTITY relationship|nmod|END_ENTITY	The relationship between binding to cytochrome_P-450 and metabolism of n-alkyl_carbamates in isolated rat hepatocytes .
16488424	0	n-alkylagaroses	31,46	fibrinogen	15,25	n-alkylagaroses	fibrinogen	null	2244	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of fibrinogen with n-alkylagaroses and its purification by critical hydrophobicity hydrophobic interaction chromatograpy .
1530638	0	n-dodecylphosphorylcholine	20,46	phospholipase_A2	91,107	n-dodecylphosphorylcholine	phospholipase A2	MESH:C028810	104974671	Chemical	Gene	mode|nmod|START_ENTITY mode|nmod|END_ENTITY	Interaction mode of n-dodecylphosphorylcholine , a substrate analogue , with bovine pancreas phospholipase_A2 as determined by X-ray crystal analysis .
1959624	0	n-hexanal	32,41	lipoxygenase-3	14,28	n-hexanal	lipoxygenase-3	MESH:C010463	547869(Tax:3847)	Chemical	Gene	generation|amod|START_ENTITY END_ENTITY|nmod|generation	Inhibition by lipoxygenase-3 of n-hexanal generation in soybeans .
11201664	0	n-hexane	88,96	Cyp2e1	11,17	n-hexane	Cyp2e1	MESH:C026385	13106(Tax:10090)	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Functional Cyp2e1 is required for substantial in vivo formation of 2,5-hexanedione from n-hexane in the mouse .
9756898	1	n-methyl-D-aspartate	193,213	insulin_receptor_substrate-1	134,162	n-methyl-D-aspartate	insulin receptor substrate-1	CHEBI:31882	25467(Tax:10116)	Chemical	Gene	action|nmod|START_ENTITY role|nmod|action role|nmod|END_ENTITY	A role for insulin_receptor_substrate-1 in the neurotrophic action of n-methyl-D-aspartate and its inhibition by ethanol .
7901336	0	nMDA	0,4	CA1	54,57	nMDA	CA1	CHEBI:6121	759	Chemical	Gene	activation|compound|START_ENTITY increases|nsubj|activation increases|nmod|END_ENTITY	nMDA receptor activation increases cyclic_AMP in area CA1 of the hippocampus via calcium/calmodulin stimulation of adenylyl cyclase .
11701998	0	nabumetone	17,27	COX-2	31,36	nabumetone	COX-2	MESH:C035605	26198(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Renal effects of nabumetone , a COX-2 antagonist : impairment of function in isolated perfused rat kidneys contrasts with preserved renal function in vivo .
19204080	0	nabumetone	51,61	CYP1A2	22,28	nabumetone	CYP1A2	MESH:C035605	1544	Chemical	Gene	metabolism|nmod|START_ENTITY role|nmod|metabolism role|nmod|END_ENTITY	A predominate role of CYP1A2 for the metabolism of nabumetone to the active metabolite , 6-methoxy-2-naphthylacetic_acid , in human liver microsomes .
16019514	0	nabumetone	29,39	Cyclo-oxygenase_2	0,17	nabumetone	Cyclo-oxygenase 2	MESH:C035605	5743	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Cyclo-oxygenase_2 inhibitor , nabumetone , inhibits proliferation in chronic_myeloid_leukemia cell lines .
18390065	0	nabumetone	23,33	cox-2	37,42	nabumetone	cox-2	MESH:C035605	4513	Chemical	Gene	START_ENTITY|appos|precursor precursor|amod|END_ENTITY	Novel determination of nabumetone , a cox-2 inhibitor precursor via its 4-carboxyl-2 ,6 - dinitrobenzene_diazonium -LRB- CDNBD -RRB- derived AZO dye .
12090350	0	nabumetone	15,25	cyclooxygenase-2	29,45	nabumetone	cyclooxygenase-2	MESH:C035605	29527(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|inhibitor inhibitor|amod|END_ENTITY	The effects of nabumetone , a cyclooxygenase-2 inhibitor , on cisplatin-induced 5-hydroxytryptamine release from the isolated rat ileum .
21225244	0	nadolol	33,40	b2AR	54,58	nadolol	b2AR	MESH:D009248	154	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|END_ENTITY	The effects of acute and chronic nadolol treatment on b2AR signaling in HEK293 cells .
15252275	0	nafadotride	147,158	dopamine_D3_receptor	11,31	nafadotride	dopamine D3 receptor	MESH:C097285	13490(Tax:10090)	Chemical	Gene	study|nmod|START_ENTITY Effects|dep|study Effects|nmod|antagonists antagonists|amod|END_ENTITY	Effects of dopamine_D3_receptor antagonists on spontaneous and agonist-reduced motor activity in NMRI mice and Wistar_rats : comparative study with nafadotride , U_99194A and SB_277011 .
15886414	0	nafadotride	19,30	dopamine_D3_receptor	34,54	nafadotride	dopamine D3 receptor	MESH:C097285	29238(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Central effects of nafadotride , a dopamine_D3_receptor antagonist , in rats .
1861238	2	nafamostat	106,116	EGF	151,154	nafamostat	EGF	MESH:C032855	1950	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|nmod|END_ENTITY	Effect of protease inhibitor , nafamostat , on stabilization and efficacy of EGF in burn .
2128896	1	nafamostat	85,95	EGF	151,154	nafamostat	EGF	MESH:C032855	1950	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	I. Effect of nafamostat , gabexate , or gelatin on stabilization and efficacy of EGF .
9127328	0	nafamostat_mesylate	28,47	myeloperoxidase	80,95	nafamostat mesylate	myeloperoxidase	MESH:C032855	4353	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nsubj|effect	Active inhibitory effect of nafamostat_mesylate against the elevation of plasma myeloperoxidase during hemodialysis .
6238805	0	nafarelin	38,47	GnRH	78,82	nafarelin	GnRH	MESH:D017274	2796	Chemical	Gene	START_ENTITY|appos|agonist agonist|nmod|END_ENTITY	Inhibition of ovulation by intranasal nafarelin , a new superactive agonist of GnRH .
8887129	0	nafarelin	47,56	Gonadotropin-releasing_hormone	0,30	nafarelin	Gonadotropin-releasing hormone	MESH:D017274	2796	Chemical	Gene	analog|appos|START_ENTITY analog|amod|END_ENTITY	Gonadotropin-releasing_hormone agonist analog -LRB- nafarelin -RRB- : a useful diagnostic agent for the distinction of constitutional growth delay from hypogonadotropic_hypogonadism .
10731543	0	nafarelin	97,106	gonadotropin-releasing_hormone	57,87	nafarelin	gonadotropin-releasing hormone	MESH:D017274	2796	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Treatment of endometriosis with a decreasing dosage of a gonadotropin-releasing_hormone agonist -LRB- nafarelin -RRB- : a pilot study with low-dose agonist therapy -LRB- `` draw-back '' therapy -RRB- .
2970910	0	nafarelin	29,38	gonadotropin-releasing_hormone	60,90	nafarelin	gonadotropin-releasing hormone	MESH:D017274	2796	Chemical	Gene	Absorption|nmod|START_ENTITY Absorption|appos|agonist agonist|nmod|END_ENTITY	Absorption and metabolism of nafarelin , a potent agonist of gonadotropin-releasing_hormone .
7599657	0	nafarelin	51,60	gonadotropin-releasing_hormone	10,40	nafarelin	gonadotropin-releasing hormone	MESH:D017274	25194(Tax:10116)	Chemical	Gene	buserelin|compound|START_ENTITY agonists|appos|buserelin agonists|amod|END_ENTITY	Effect of gonadotropin-releasing_hormone agonists , nafarelin , buserelin , and leuprolide , on experimentally induced endometriosis in the rat .
2931517	0	nafarelin_acetate	60,77	LHRH	88,92	nafarelin acetate	LHRH	MESH:D017274	2796	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Long-term reversible suppression of oestrus in bitches with nafarelin_acetate , a potent LHRH agonist .
3156111	0	nafarelin_acetate	67,84	LHRH	95,99	nafarelin acetate	LHRH	MESH:D017274	2796	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Dose-response studies on male reproductive parameters in dogs with nafarelin_acetate , a potent LHRH agonist .
17057847	0	nagstatin	48,57	O-GlcNAcase	14,25	nagstatin	O-GlcNAcase	MESH:C077641	10724	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of O-GlcNAcase by a gluco-configured nagstatin and a PUGNAc-imidazole hybrid inhibitor .
21761732	0	najanalgesin	14,26	GLT-1	45,50	najanalgesin	GLT-1	MESH:C543072	29482(Tax:10116)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	-LSB- Influence of najanalgesin from Naja_naja on GLT-1 in spinal cord of rat in neuropathic_pain -RSB- .
21226314	0	nalfurafine_hydrochloride	28,53	kappa-opioid_receptor	57,78	nalfurafine hydrochloride	kappa-opioid receptor	MESH:C111212	4986	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	-LSB- Pharmacological effects of nalfurafine_hydrochloride , a kappa-opioid_receptor agonist -RSB- .
6446258	0	nalidixic_acid	49,63	AM-715	35,41	nalidixic acid	AM-715	MESH:D009268	3171190(Tax:234826)	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	In vitro antibacterial activity of AM-715 , a new nalidixic_acid analog .
2545393	0	naloxone	60,68	ACTH	37,41	naloxone	ACTH	MESH:D009270	5443	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|Potentiation Potentiation|nmod|END_ENTITY	Potentiation of fenfluramine-induced ACTH release in man by naloxone .
2840381	0	naloxone	23,31	ACTH	51,55	naloxone	ACTH	MESH:D009270	5443	Chemical	Gene	infusion|compound|START_ENTITY infusion|nmod|END_ENTITY	The effect of low-dose naloxone infusion on plasma ACTH and LH in patients with Cushing 's and Addison 's _ diseases .
2983909	0	naloxone	34,42	ACTH	53,57	naloxone	ACTH	MESH:D009270	5443	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of high-dose and low-dose naloxone on plasma ACTH in patients with ACTH_hypersecretion .
2994140	0	naloxone	141,149	ACTH	62,66	naloxone	ACTH	MESH:D009270	5443	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|memory memory|nmod|injections injections|nmod|epinephrine epinephrine|nummod|END_ENTITY	Influence on memory of posttraining or pre-test injections of ACTH , vasopressin , epinephrine , and beta-endorphin , and their interaction with naloxone .
6276118	0	naloxone	85,93	ACTH	68,72	naloxone	ACTH	MESH:D009270	5443	Chemical	Gene	lack|acl|START_ENTITY lack|nmod|response response|compound|END_ENTITY	Evidence for an endorphin dysfunction in methadone addicts : lack of ACTH response to naloxone .
2555640	0	naloxone	24,32	ACTH_and_prolactin	72,90	naloxone	ACTH and prolactin	MESH:D009270	24683(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|release release|nmod|END_ENTITY	Differential effects of naloxone on basal and stress-induced release of ACTH_and_prolactin in the male rat .
11955465	0	naloxone	48,56	Adrenocorticotropin	0,19	naloxone	Adrenocorticotropin	MESH:D009270	5443	Chemical	Gene	challenge|amod|START_ENTITY responses|nmod|challenge responses|compound|END_ENTITY	Adrenocorticotropin and cortisol responses to a naloxone challenge and risk of alcoholism .
9920063	0	naloxone	33,41	Adrenocorticotropin	0,19	naloxone	Adrenocorticotropin	MESH:D009270	5443	Chemical	Gene	responses|xcomp|START_ENTITY responses|nsubj|END_ENTITY	Adrenocorticotropin responses to naloxone in sons of alcohol-dependent men .
2995021	0	naloxone	10,18	CRF	46,49	naloxone	CRF	MESH:D009270	1392	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|response response|nmod|END_ENTITY	Effect of naloxone on the hormone response to CRF in normal man .
11288030	0	naloxone	64,72	GH	121,123	naloxone	GH	MESH:D009270	2688	Chemical	Gene	START_ENTITY|nmod|growth_hormone growth_hormone|appos|END_ENTITY	Opioid_dysregulation after biliopancreatic_diversion : effect of naloxone on preprandial and postprandial growth_hormone -LRB- GH -RRB- - releasing hormone-induced GH release in surgically induced weight_loss .
25051048	0	naloxone	52,60	HSP60	0,5	naloxone	HSP60	MESH:D009270	15510(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY involved|nmod|effects involved|nsubjpass|END_ENTITY	HSP60 is involved in the neuroprotective effects of naloxone .
8097244	0	naloxone	68,76	Mu_opiate_receptor	0,18	naloxone	Mu opiate receptor	MESH:D009270	4988	Chemical	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	Mu_opiate_receptor down-regulation by morphine and up-regulation by naloxone in SH-SY5Y human neuroblastoma cells .
2503692	0	naloxone	10,18	PRL_and_TSH	34,45	naloxone	PRL and TSH	MESH:D009270	5617	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|response response|amod|END_ENTITY	Effect of naloxone on TRH-induced PRL_and_TSH response in normal man .
2605788	0	naloxone	98,106	Vasopressin	0,11	naloxone	Vasopressin	MESH:D009270	551	Chemical	Gene	effect|nmod|START_ENTITY responses|dep|effect responses|compound|END_ENTITY	Vasopressin and oxytocin responses to hypertonic saline infusion : effect of the opioid antagonist naloxone .
3720019	0	naloxone	14,22	angiotensin_II	47,61	naloxone	angiotensin II	MESH:D009270	183	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of naloxone on pressor responses to angiotensin_II in anaesthetized greyhounds .
9005170	0	naloxone	12,20	atrial_natriuretic_factor	41,66	naloxone	atrial natriuretic factor	MESH:D009270	4878	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|nmod|END_ENTITY	-LSB- Effects of naloxone on plasma levels of atrial_natriuretic_factor and noradrenaline during water load in moderate heart_failure -RSB- .
2944031	0	naloxone	159,167	beta-Endorphin	0,14	naloxone	beta-Endorphin	MESH:D009270	5443	Chemical	Gene	related|xcomp|START_ENTITY related|nsubj|levels levels|amod|END_ENTITY	beta-Endorphin levels in the cerebrospinal fluid of male talapoin monkeys in social groups related to dominance status and the luteinizing hormone response to naloxone .
2949952	0	naloxone	104,112	beta-endorphin	17,31	naloxone	beta-endorphin	MESH:D009270	5443	Chemical	Gene	therapy|amod|START_ENTITY relation|nmod|therapy Determination|dep|relation Determination|nmod|END_ENTITY	Determination of beta-endorphin in alcoholic patients in the acute stage of intoxication : relation with naloxone therapy .
6308701	0	naloxone	45,53	beta-endorphin	29,43	naloxone	beta-endorphin	MESH:D009270	5443	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|amod|END_ENTITY	Effect of ACTH , epinephrine , beta-endorphin , naloxone , and of the combination of naloxone or beta-endorphin with ACTH or epinephrine on memory consolidation .
731437	0	naloxone	22,30	beta-endorphin	44,58	naloxone	beta-endorphin	MESH:D009270	18976(Tax:10090)	Chemical	Gene	antagonism|nmod|START_ENTITY analog|nmod|antagonism analog|nsubj|END_ENTITY	In vivo antagonism by naloxone of morphine , beta-endorphin and a synthetic enkephalin analog .
8055820	0	naloxone	11,19	beta-endorphin	23,37	naloxone	beta-endorphin	MESH:D009270	5443	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|concentrations concentrations|compound|END_ENTITY	-LSB- Effect of naloxone on beta-endorphin and insulin concentrations during glucose tolerance testing in patients with simple_obesity -RSB- .
1933140	0	naloxone	15,23	corticotrophin_releasing_factor	96,127	naloxone	corticotrophin releasing factor	MESH:D009270	100301553(Tax:9986)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of naloxone on the cardiovascular and respiratory effects of centrally administered corticotrophin_releasing_factor in conscious rabbits .
1847734	0	naloxone	127,135	enkephalin	40,50	naloxone	enkephalin	MESH:D009270	29237(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY and|dep|effect and|dep|increase increase|compound|END_ENTITY	Morphine and -LRB- D-Ala2 , NMe-Phe4 , Gly-ol -RRB- - enkephalin increase the intracellular free calcium in isolated rat myocytes -- effect of naloxone or pretreatment with morphine .
2543999	0	naloxone	10,18	growth_hormone	26,40	naloxone	growth hormone	MESH:D009270	2688	Chemical	Gene	START_ENTITY|nmod|response response|amod|END_ENTITY	Effect of naloxone on the growth_hormone response to clonidine in normal women during the mid-luteal phase .
2827218	0	naloxone	64,72	growth_hormone	37,51	naloxone	growth hormone	MESH:D009270	2688	Chemical	Gene	affect|advcl|START_ENTITY affect|dobj|response response|compound|END_ENTITY	Gonadal steroids do not affect basal growth_hormone response to naloxone in humans .
3100909	0	naloxone	12,20	growth_hormone	75,89	naloxone	growth hormone	MESH:D009270	2688	Chemical	Gene	influence|nsubj|START_ENTITY influence|nmod|secretion secretion|compound|END_ENTITY	Sex-related naloxone influence on growth_hormone-releasing_hormone-induced growth_hormone secretion in normal subjects .
391445	0	naloxone	11,19	growth_hormone	29,43	naloxone	growth hormone	MESH:D009270	2688	Chemical	Gene	Failure|nmod|START_ENTITY Failure|acl|alter alter|dobj|levels levels|compound|END_ENTITY	Failure of naloxone to alter growth_hormone and prolactin levels in acromegalic and in hyperprolactinaemic patients .
6319449	0	naloxone	20,28	growth_hormone	69,83	naloxone	growth hormone	MESH:D009270	2688	Chemical	Gene	blockade|nmod|START_ENTITY END_ENTITY|nsubj|blockade	Partial blockade by naloxone of clonidine-induced increase in plasma growth_hormone in hypertensive patients .
6833931	0	naloxone	11,19	growth_hormone	74,88	naloxone	growth hormone	MESH:D009270	81668(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|monosodium-L-glutamate monosodium-L-glutamate|nmod|release release|compound|END_ENTITY	Effects of naloxone and neonatal treatment with monosodium-L-glutamate on growth_hormone and prolactin release induced by electrical stimulation of the medial-basal hypothalamus in rats .
6987258	0	naloxone	11,19	growth_hormone	40,54	naloxone	growth hormone	MESH:D009270	2688	Chemical	Gene	START_ENTITY|acl|influence influence|dobj|END_ENTITY	Failure of naloxone to influence plasma growth_hormone , prolactin , and cortisol secretions induced by insulin_hypoglycemia .
7226565	0	naloxone	11,19	growth_hormone	46,60	naloxone	growth hormone	MESH:D009270	2688	Chemical	Gene	Failure|nmod|START_ENTITY Failure|acl|alter alter|dobj|END_ENTITY	Failure of naloxone to alter exercise-induced growth_hormone and prolactin release in normal men .
7266088	0	naloxone	101,109	growth_hormone	20,34	naloxone	growth hormone	MESH:D009270	2688	Chemical	Gene	study|nmod|START_ENTITY control|dep|study control|nmod|secretion secretion|amod|END_ENTITY	Abnormal control of growth_hormone secretion by opiate systems in acromegalic patients : a study with naloxone and 2-Br-alpha-ergocryptine -LRB- CB_154 -RRB- .
7379756	2	naloxone	74,82	growth_hormone	98,112	naloxone	growth hormone	MESH:D009270	2688	Chemical	Gene	START_ENTITY|advcl|circulating circulating|dobj|END_ENTITY	The effects of beta-endorphin and naloxone on circulating growth_hormone , prolactin , and chorionic somatomammotropin .
8121292	0	naloxone	42,50	growth_hormone	91,105	naloxone	growth hormone	MESH:D009270	2688	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|response response|amod|END_ENTITY	Opioid_dysregulation in anorexia_nervosa : naloxone effects on preprandial and postprandial growth_hormone response to growth_hormone-releasing hormone .
9667227	0	naloxone	21,29	growth_hormone	37,51	naloxone	growth hormone	MESH:D009270	2688	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|response response|amod|END_ENTITY	Different effects of naloxone on the growth_hormone response to melatonin and pyridostigmine in normal men .
7006632	0	naloxone	69,77	insulin	96,103	naloxone	insulin	MESH:D009270	3630	Chemical	Gene	START_ENTITY|nmod|control control|nmod|secretion secretion|compound|END_ENTITY	-LSB- Effects of interaction between 2-Br-alpha-ergocriptine -LRB- CB_154 -RRB- and naloxone on the control of insulin secretion in normal men -RSB- .
19799935	0	naloxone	15,23	interleukin-10	36,50	naloxone	interleukin-10	MESH:D009270	25325(Tax:10116)	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Ultra-low dose naloxone upregulates interleukin-10 expression and suppresses neuroinflammation in morphine-tolerant rat spinal cords .
3297642	0	naloxone	185,193	luteinizing_hormone-releasing_hormone	118,155	naloxone	luteinizing hormone-releasing hormone	MESH:D009270	25194(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY vitro|dep|effects +|amod|vitro release|nmod|+ release|amod|END_ENTITY	The effect of hyperprolactinemia produced by transplantable pituitary MtTW15 tumor cells in male rats on hypothalamic luteinizing_hormone-releasing_hormone release in vitro : effects of naloxone and K + .
3749403	0	naloxone	13,21	oxytocin	32,40	naloxone	oxytocin	MESH:D009270	5020	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	No effect of naloxone on plasma oxytocin in normal men .
9231264	1	naloxone	174,182	oxytocin	69,77	naloxone	oxytocin	MESH:D009270	100152272(Tax:9823)	Chemical	Gene	stimulation|nmod|START_ENTITY secretion|nmod|stimulation secretion|nsubj|Effects Effects|nmod|END_ENTITY	Effects on oxytocin , vasopressin and cortisol secretion following vagino-cervical stimulation and administration of naloxone .
10451223	0	naloxone	11,19	prolactin	42,51	naloxone	prolactin	MESH:D009270	24683(Tax:10116)	Chemical	Gene	infusion|amod|START_ENTITY Effects|nmod|infusion Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of naloxone infusion on nocturnal prolactin secretion and Fos/FRA expression in pregnant rats .
16727287	0	naloxone	11,19	prolactin	72,81	naloxone	prolactin	MESH:D009270	100009394(Tax:9986)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of naloxone , metaclopramide and domperidone on plasma levels of prolactin and LH following suckling in the female rabbit .
17045431	0	naloxone	25,33	prolactin	64,73	naloxone	prolactin	MESH:D009270	5617	Chemical	Gene	doses|nmod|START_ENTITY Effect|nmod|doses Effect|nmod|secretion secretion|nmod|END_ENTITY	Effect of small doses of naloxone on the pulsatile secretion of prolactin in the crossbreed ewe during the non-breeding season .
1811245	0	naloxone	13,21	prolactin	34,43	naloxone	prolactin	MESH:D009270	5617	Chemical	Gene	infusion|amod|START_ENTITY infusion|nmod|response response|compound|END_ENTITY	Influence of naloxone infusion on prolactin and growth_hormone response to growth_hormone-releasing hormone in anorexia_nervosa .
19210416	5	naloxone	964,972	prolactin	1072,1081	naloxone	prolactin	MESH:D009270	24683(Tax:10116)	Chemical	Gene	added|nsubjpass|START_ENTITY capable|advcl|added capable|advcl|stimulating stimulating|dobj|release release|compound|END_ENTITY	When naloxone , the opiate receptor antagonist , was added to the perfusate , ss-END was not capable of stimulating prolactin release .
223091	0	naloxone	46,54	prolactin	150,159	naloxone	prolactin	MESH:D009270	5617	Chemical	Gene	2-Br-alpha-ergocryptine|dep|START_ENTITY 2-Br-alpha-ergocryptine|advcl|luteinizing luteinizing|dobj|levels levels|compound|END_ENTITY	A study on the effects of interaction between naloxone and 2-Br-alpha-ergocryptine or clonidine on luteinizing hormone , follicle-stimulating hormone , prolactin and thyroid-stimulating hormone levels in normal man serum .
2384365	0	naloxone	48,56	prolactin	6,15	naloxone	prolactin	MESH:D009270	5617	Chemical	Gene	Serum|xcomp|START_ENTITY Serum|dobj|responses responses|compound|END_ENTITY	Serum prolactin and growth_hormone responses to naloxone and intracerebral ventricle morphine administration in heifers .
2693516	0	naloxone	11,19	prolactin	23,32	naloxone	prolactin	MESH:D009270	5617	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|response response|amod|END_ENTITY	Effects of naloxone on prolactin , growth_hormone and cortisol response to insulin hypoglycemia in obese subjects .
2723127	5	naloxone	823,831	prolactin	899,908	naloxone	prolactin	MESH:D009270	5617	Chemical	Gene	mg|nmod|START_ENTITY injected|nsubjpass|mg lower|advcl|injected lower|nsubj|levels levels|compound|END_ENTITY	When 0.6 mg of naloxone was simultaneously injected with 0.3 mg buprenorphine , peak plasma prolactin levels were significantly lower -LRB- p less than 0.05 -RRB- than prolactin values after administration of 0.3 mg buprenorphine and saline .
2990210	4	naloxone	923,931	prolactin	870,879	naloxone	prolactin	MESH:D009270	5617	Chemical	Gene	humans|nmod|START_ENTITY receptors|nmod|humans blockade|nmod|receptors failed|nsubj|blockade failed|advcl|opioid opioid|ccomp|induce induce|dobj|secretion secretion|nmod|END_ENTITY	Although exogenous opioid peptides and their synthetic analogs consistently induce the secretion of prolactin , blockade of opioid receptors in humans by naloxone failed to elicit a decrement in the levels of prolactin under a variety of conditions .
2995857	0	naloxone	44,52	prolactin	22,31	naloxone	prolactin	MESH:D009270	5617	Chemical	Gene	modulate|xcomp|START_ENTITY modulate|dobj|response response|compound|END_ENTITY	Sex steroids modulate prolactin response to naloxone in postmenopausal women .
3108600	0	naloxone	31,39	prolactin	43,52	naloxone	prolactin	MESH:D009270	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|response response|compound|END_ENTITY	In vivo and in vitro effect of naloxone on prolactin response to TRH in rat .
3921597	0	naloxone	29,37	prolactin	57,66	naloxone	prolactin	MESH:D009270	5617	Chemical	Gene	doses|nmod|START_ENTITY Effect|nmod|doses Effect|nmod|levels levels|nmod|END_ENTITY	Effect of different doses of naloxone on serum levels of prolactin and gonadotropins in young male volunteers .
3944789	0	naloxone	10,18	prolactin	47,56	naloxone	prolactin	MESH:D009270	5617	Chemical	Gene	START_ENTITY|nmod|concentrations concentrations|nmod|END_ENTITY	Effect of naloxone on plasma concentrations of prolactin and LH in lactating sows .
4034850	0	naloxone	54,62	prolactin	26,35	naloxone	prolactin	MESH:D009270	5617	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|responses responses|nmod|levels levels|compound|END_ENTITY	Differential responses in prolactin levels induced by naloxone in humans .
420037	0	naloxone	10,18	prolactin	44,53	naloxone	prolactin	MESH:D009270	5617	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|concentrations concentrations|compound|END_ENTITY	Effect of naloxone or levallorphan on serum prolactin concentrations and apomorphine-induced growth_hormone secretion .
6602260	0	naloxone	11,19	prolactin	40,49	naloxone	prolactin	MESH:D009270	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|nmod|END_ENTITY	Effects of naloxone on the secretion of prolactin and corticosterone induced by 5-hydroxytryptophan and a serotonergic agonist , mCPP .
6685061	0	naloxone	11,19	prolactin	69,78	naloxone	prolactin	MESH:D009270	5617	Chemical	Gene	infusion|amod|START_ENTITY Effects|nmod|infusion Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of naloxone infusion on basal and breast-stimulation-induced prolactin secretion in puerperal women .
6780252	0	naloxone	12,20	prolactin	61,70	naloxone	prolactin	MESH:D009270	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|surge surge|nmod|END_ENTITY	-LSB- Effects of naloxone and morphine on the proestrous surge of prolactin and gonadotropins in the rat -LRB- author 's transl -RRB- -RSB- .
6854313	0	naloxone	14,22	prolactin	48,57	naloxone	prolactin	MESH:D009270	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	Inhibition by naloxone of the serotonin-induced prolactin release in free-moving rats .
6882542	0	naloxone	86,94	prolactin	64,73	naloxone	prolactin	MESH:D009270	5617	Chemical	Gene	Evidence|acl|START_ENTITY Evidence|nmod|effect effect|nmod|response response|compound|END_ENTITY	Evidence for a dose-dependent effect in the sex-specific plasma prolactin response to naloxone in humans .
6983432	0	naloxone	10,18	prolactin	43,52	naloxone	prolactin	MESH:D009270	24683(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY induced|nsubj|Effect induced|dobj|release release|compound|END_ENTITY	Effect of naloxone on the suckling induced prolactin release in rats .
7085859	0	naloxone	11,19	prolactin	23,32	naloxone	prolactin	MESH:D009270	5617	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of naloxone on prolactin , luteinizing hormone , and cortisol responses to surgical stress in humans .
7393831	0	naloxone	14,22	prolactin	52,61	naloxone	prolactin	MESH:D009270	5617	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	The effect of naloxone on psychotropic drug-induced prolactin , growth_hormone and cortisol secretion -- a preliminary report .
9122001	0	naloxone	42,50	prolactin	54,63	naloxone	prolactin	MESH:D009270	5617	Chemical	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	-LSB- Effects of opiate receptor blockade with naloxone on prolactin -LRB- PRL -RRB- secretion in patients with diabetes_type_I -LRB- IDDM -RRB- with chronic_renal_failure treated with hemodialysis -LRB- HD -RRB- -RSB- .
9718072	0	naloxone	10,18	prolactin	28,37	naloxone	prolactin	MESH:D009270	100009394(Tax:9986)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|compound|END_ENTITY	Effect of naloxone on serum prolactin levels in adult male rabbits .
2205111	0	naloxone	11,19	renin	23,28	naloxone	renin	MESH:D009270	24715(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|responses responses|compound|END_ENTITY	Effects of naloxone on renin and pressor responses to acute renal_hypotension in rats .
20450556	0	naloxone	12,20	stem_cell_factor	42,58	naloxone	stem cell factor	MESH:D009270	4254	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of naloxone on the expression of stem_cell_factor and C-kit receptor in combined oxygen-glucose deprivation of primary cultured human embryonic neuron in vitro -RSB- .
17216288	0	naloxone	167,175	tyrosine_hydroxylase	116,136	naloxone	tyrosine hydroxylase	MESH:D009270	25085(Tax:10116)	Chemical	Gene	withdrawal|compound|START_ENTITY heart|nmod|withdrawal expression|nmod|heart expression|amod|END_ENTITY	Differential involvement of 3 ' , 5 ' - cyclic_adenosine_monophosphate-dependent protein kinase in regulation of Fos and tyrosine_hydroxylase expression in the heart after naloxone induced morphine withdrawal .
1336854	0	naloxone	41,49	vasopressin	53,64	naloxone	vasopressin	MESH:D009270	551	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	-LSB- Effect of opioid receptor blockade with naloxone on vasopressin secretion in patients with transplanted kidney -RSB- .
20626732	0	naltrexone	81,91	FosB	29,33	naltrexone	FosB	MESH:D009271	100360880	Chemical	Gene	effects|nmod|START_ENTITY FosB|dep|effects induction|parataxis|FosB induction|nmod|END_ENTITY	Region-specific induction of FosB / / \ FosB by voluntary alcohol intake : effects of naltrexone .
20626732	0	naltrexone	81,91	FosB	36,40	naltrexone	FosB	MESH:D009271	100360880	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|dep|effects	Region-specific induction of FosB / / \ FosB by voluntary alcohol intake : effects of naltrexone .
20702761	7	naltrexone	1127,1137	MOR	1172,1175	naltrexone	MOR	MESH:D009271	4988	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|compound|END_ENTITY	Surface expression of the N190K variant could be increased by incubation with the alkaloid agonist buprenorphine or with either naltrexone or naloxone , structurally related MOR antagonists .
22771010	0	naltrexone	65,75	MOR	113,116	naltrexone	MOR	MESH:D009271	4988	Chemical	Gene	opiates|nmod|START_ENTITY opiates|nmod|agonist agonist|compound|END_ENTITY	An efficient synthesis of 3-OBn-6b ,14 - epoxy-bridged opiates from naltrexone and identification of a related dual MOR inverse agonist/KOR agonist .
18427989	0	naltrexone	11,21	NGFI-A	57,63	naltrexone	NGFI-A	MESH:D009271	13653(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|amod|END_ENTITY	Effects of naltrexone and acamprosate on alcohol-induced NGFI-A expression in mouse brain .
12188097	0	naltrexone	75,85	beta-endorphin	24,38	naltrexone	beta-endorphin	MESH:D009271	5443	Chemical	Gene	pretreatment|amod|START_ENTITY urge|nmod|pretreatment urge|dobj|change change|amod|END_ENTITY	Alcohol urge and plasma beta-endorphin change after alcohol challenge with naltrexone pretreatment in social drinkers .
16934320	0	naltrexone	144,154	beta-endorphin	45,59	naltrexone	beta-endorphin	MESH:D009271	5443	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|Effect Effect|acl|preferring preferring|nsubj|administration administration|nmod|ethanol ethanol|nmod|level level|amod|END_ENTITY	Effect of acute administration of ethanol on beta-endorphin plasma level in ethanol preferring and non-preferring rats chronically treated with naltrexone .
2527243	0	naltrexone	142,152	beta-endorphin	30,44	naltrexone	beta-endorphin	MESH:D009271	5443	Chemical	Gene	effect|nmod|START_ENTITY performance|nmod|effect relationship|nmod|performance relationship|dep|Increase Increase|nmod|melatonin melatonin|appos|END_ENTITY	Increase in plasma melatonin , beta-endorphin , and cortisol after a 28.5-mile mountain race : relationship to performance and lack of effect of naltrexone .
2944913	0	naltrexone	15,25	beta-endorphin	35,49	naltrexone	beta-endorphin	MESH:D009271	5443	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	The effects of naltrexone , an oral beta-endorphin antagonist , in children with the Prader-Willi_syndrome .
25586403	0	naltrexone	42,52	dopamine_transporter	79,99	naltrexone	dopamine transporter	MESH:D009271	24898(Tax:10116)	Chemical	Gene	administration|nmod|START_ENTITY has|nsubj|administration has|dobj|effect effect|nmod|intake intake|compound|END_ENTITY	Subchronic administration of short-acting naltrexone has no effect on striatal dopamine_transporter availability , food intake or body weight_gain in rats .
25757673	0	naltrexone	27,37	dopamine_transporter	50,70	naltrexone	dopamine transporter	MESH:D009271	6531	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of extended-release naltrexone on striatal dopamine_transporter availability , depression and anhedonia in heroin-dependent patients .
9160821	0	naltrexone	20,30	growth_hormone	44,58	naltrexone	growth hormone	MESH:D009271	2688	Chemical	Gene	treatment|compound|START_ENTITY treatment|nmod|END_ENTITY	Impact of long-term naltrexone treatment on growth_hormone and insulin secretion in hyperandrogenic and normal obese patients .
9437228	0	naltrexone	21,31	growth_hormone	45,59	naltrexone	growth hormone	MESH:D009271	2688	Chemical	Gene	treatment|compound|START_ENTITY treatment|nmod|secretion secretion|amod|END_ENTITY	Influence of chronic naltrexone treatment on growth_hormone secretion in normal subjects .
2578990	0	naltrexone	24,34	nicotinic_acetylcholine_receptor	64,96	naltrexone	nicotinic acetylcholine receptor	MESH:D009271	170945(Tax:10116)	Chemical	Gene	has|nsubj|START_ENTITY has|dobj|effect effect|nmod|END_ENTITY	The narcotic antagonist naltrexone has a biphasic effect on the nicotinic_acetylcholine_receptor .
8464327	0	naltrexone-estrone_azine	33,57	luteinizing_hormone-releasing_hormone	65,102	naltrexone-estrone azine	luteinizing hormone-releasing hormone	MESH:C073580	25194(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|release release|amod|END_ENTITY	Effects of the opioid antagonist naltrexone-estrone_azine on the luteinizing_hormone-releasing_hormone induced release of luteinizing hormone from the pituitary glands of ovariectomized rats .
19601874	0	nandrolone_decanoate	59,79	cytochrome_p-450	28,44	nandrolone decanoate	cytochrome p-450	MESH:C003297	13079(Tax:10090)	Chemical	Gene	activities|nmod|START_ENTITY activities|amod|END_ENTITY	Enhanced hepatic and kidney cytochrome_p-450 activities in nandrolone_decanoate treated albino mice .
16153628	0	nandrolone_decanonate	10,31	paraoxonase	35,46	nandrolone decanonate	paraoxonase	null	5444	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	Effect of nandrolone_decanonate on paraoxonase activity in hemodialysis patients .
24104196	0	naphthalene	85,96	CYP2A5	45,51	naphthalene	CYP2A5	MESH:C031721	13087(Tax:10090)	Chemical	Gene	toxicity|nmod|START_ENTITY END_ENTITY|nmod|toxicity	Essential role of the cytochrome P450 enzyme CYP2A5 in olfactory mucosal toxicity of naphthalene .
19034370	0	naphthalene	35,46	N-acetyl-beta-glucosaminidase	66,95	naphthalene	N-acetyl-beta-glucosaminidase	MESH:C031721	10724	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	Effects of hypoxia and sedimentary naphthalene on the activity of N-acetyl-beta-glucosaminidase in the epidermis of the brown shrimp , Penaeus aztecus .
16220979	0	naphthalenes	23,35	CYP11B2	99,106	naphthalenes	CYP11B2	MESH:D009281	1585	Chemical	Gene	START_ENTITY|dep|inhibitors inhibitors|nmod|END_ENTITY	Heteroaryl-substituted naphthalenes and structurally modified derivatives : selective inhibitors of CYP11B2 for the treatment of congestive_heart_failure and myocardial_fibrosis .
12929468	0	naphthalenophanes	33,50	syn	107,110	naphthalenophanes	syn	null	23336	Chemical	Gene	START_ENTITY|nmod|reaction reaction|nmod|END_ENTITY	Syntheses of various symmetrical naphthalenophanes and anthracenophanes via a Diels-Alder reaction between syn - -LSB- 2.2 -RSB- -LRB- 5,8 -RRB- phthalazinophane derivatives and some selected dienophiles as well as the synthesis of other symmetrical heterophanes .
22569532	0	naphthols	22,31	tyrosinase	60,70	naphthols	tyrosinase	MESH:D009284	7299	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nsubj|effects	Inhibitory effects of naphthols on the activity of mushroom tyrosinase .
16797987	0	naphthophenone_fatty_acid_amides	31,63	cathepsin_D	67,78	naphthophenone fatty acid amides	cathepsin D	null	1509	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Synthesis of gallic_acid based naphthophenone_fatty_acid_amides as cathepsin_D inhibitors .
15921913	0	naphthoquinone	54,68	CDC25	86,91	naphthoquinone	CDC25	CHEBI:25481	995	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	Design , synthesis , and biological evaluation of novel naphthoquinone derivatives with CDC25 phosphatase inhibitory activity .
15638999	0	naphthoquinone	69,83	Nox-4	14,19	naphthoquinone	Nox-4	CHEBI:25481	50507	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|activity activity|compound|END_ENTITY	Inhibition of Nox-4 activity by plumbagin , a plant-derived bioactive naphthoquinone .
25190151	0	naphthoquinones	16,31	neuraminidase	37,50	naphthoquinones	neuraminidase	MESH:D009285	4758	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Two new dimeric naphthoquinones with neuraminidase inhibitory activity from Lithospermum erythrorhizon .
26318997	0	naphthyl_chalcones	57,75	tyrosinase	88,98	naphthyl chalcones	tyrosinase	null	7299	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Integrated kinetic studies and computational analysis on naphthyl_chalcones as mushroom tyrosinase inhibitors .
26077488	0	naphthyridines	42,56	c-Met	70,75	naphthyridines	c-Met	MESH:D009287	4233	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Design and synthesis of novel substituted naphthyridines as potential c-Met kinase inhibitors based on MK-2461 .
18479914	0	naphthyridinone	42,57	Akt1	25,29	naphthyridinone	Akt1	null	11651(Tax:10090)	Chemical	Gene	inhibitors|dep|START_ENTITY inhibitors|nmod|END_ENTITY	Allosteric inhibitors of Akt1 and Akt2 : a naphthyridinone with efficacy in an A2780 tumor xenograft model .
10955327	0	naproxen	90,98	COX-2	52,57	naproxen	COX-2	MESH:D009288	4513	Chemical	Gene	gastrointestinal|advcl|START_ENTITY gastrointestinal|dobj|tolerability tolerability|nmod|celecoxib celecoxib|appos|inhibitor inhibitor|amod|specific specific|amod|END_ENTITY	Upper gastrointestinal tolerability of celecoxib , a COX-2 specific inhibitor , compared to naproxen and placebo .
11950252	0	naproxen	174,182	COX-2	27,32	naproxen	COX-2	MESH:D009288	4513	Chemical	Gene	comparison|nmod|START_ENTITY Efficacy|dep|comparison Efficacy|nmod|valdecoxib valdecoxib|compound|END_ENTITY	Efficacy and safety of the COX-2 specific inhibitor valdecoxib in the management of osteoarthritis_of_the_hip : a randomized , double-blind , placebo-controlled comparison with naproxen .
16522321	0	naproxen	21,29	COX-2	84,89	naproxen	COX-2	MESH:D009288	17709(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Protective effect of naproxen -LRB- non-selective COX-inhibitor -RRB- or rofecoxib -LRB- selective COX-2 inhibitor -RRB- on immobilization stress-induced behavioral and biochemical alterations in mice .
18787084	0	naproxen	83,91	COX-2	135,140	naproxen	COX-2	MESH:D009288	4513	Chemical	Gene	START_ENTITY|dep|analysis analysis|nmod|inhibitor inhibitor|compound|END_ENTITY	The risk of acute_myocardial_infarction with etodolac is not increased compared to naproxen : a historical cohort analysis of a generic COX-2 selective inhibitor .
19280158	0	naproxen	53,61	CYP2C9	10,16	naproxen	CYP2C9	MESH:D009288	1559	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY allele|nmod|pharmacokinetics allele|nsubj|Effect Effect|nmod|END_ENTITY	Effect of CYP2C9 * 3 allele on the pharmacokinetics of naproxen in Korean subjects .
16187975	0	naproxen	170,178	UGT2B7	141,147	naproxen	UGT2B7	MESH:D009288	7364	Chemical	Gene	elimination|nmod|START_ENTITY END_ENTITY|nmod|elimination	S-Naproxen and desmethylnaproxen glucuronidation by human liver microsomes and recombinant human UDP-glucuronosyltransferases -LRB- UGT -RRB- : role of UGT2B7 in the elimination of naproxen .
10425885	0	naproxen_sodium	11,26	IL-1	54,58	naproxen sodium	IL-1	CHEBI:7477	3553	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|concentrations concentrations|nmod|END_ENTITY	-LSB- Effect of naproxen_sodium on serum concentrations of IL-1 , IL-6 , and TNF in patients with acute , purulent pharyngo-tonsillitis -RSB- .
10909271	1	naproxene	73,82	COX-1	124,129	naproxene	COX-1	CHEBI:7476	4512	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Inhibitory effect of naproxene and its 7-methoxy isomer on constitutive COX-1 and inducible COX-2 .
10197423	0	napsagatran	67,78	thrombin	103,111	napsagatran	thrombin	MESH:C087198	2147	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Interspecies pharmacokinetic comparisons and allometric scaling of napsagatran , a low molecular weight thrombin inhibitor .
10235427	0	napsagatran	111,122	thrombin	27,35	napsagatran	thrombin	MESH:C087198	2147	Chemical	Gene	inhibitor|appos|START_ENTITY generation|nmod|inhibitor generation|nsubj|inhibition inhibition|nmod|activity activity|compound|END_ENTITY	Differential inhibition of thrombin activity and thrombin generation by a synthetic direct thrombin inhibitor -LRB- napsagatran , Ro 46-6240 -RRB- and unfractionated heparin in patients with deep_vein_thrombosis .
10235427	0	napsagatran	111,122	thrombin	91,99	napsagatran	thrombin	MESH:C087198	2147	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Differential inhibition of thrombin activity and thrombin generation by a synthetic direct thrombin inhibitor -LRB- napsagatran , Ro 46-6240 -RRB- and unfractionated heparin in patients with deep_vein_thrombosis .
9308743	0	napsagatran	77,88	thrombin	57,65	napsagatran	thrombin	MESH:C087198	2147	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	An exploratory trial of two dosages of a novel synthetic thrombin inhibitor -LRB- napsagatran , Ro 46-6240 -RRB- compared with unfractionated heparin for treatment of proximal deep-vein_thrombosis -- results of the European multicenter ADVENT trial .
15460448	0	naringenin	36,46	CYP1A1	15,21	naringenin	CYP1A1	MESH:C005273	13076(Tax:10090)	Chemical	Gene	Suppression|nmod|START_ENTITY Suppression|nmod|expression expression|compound|END_ENTITY	Suppression of CYP1A1 expression by naringenin in murine Hepa-1c1c7 cells .
24842554	0	naringenin	21,31	NOD2	80,84	naringenin	NOD2	MESH:C005273	291912(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|END_ENTITY	Protective effect of naringenin in experimental ischemic_stroke : down-regulated NOD2 , RIP2 , NF-kB , MMP-9 and up-regulated claudin-5 expression .
16341574	0	naringenin	26,36	Smad3	0,5	naringenin	Smad3	MESH:C005273	25631(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Smad3 specific inhibitor , naringenin , decreases the expression of extracellular matrix induced by TGF-beta1 in cultured rat hepatic stellate cells .
26496980	0	naringenin	33,43	THP-1	16,21	naringenin	THP-1	MESH:C005273	2736	Chemical	Gene	cells|nmod|START_ENTITY cells|compound|END_ENTITY	Co-treatment of THP-1 cells with naringenin and curcumin induces cell cycle arrest and apoptosis via numerous pathways .
12235187	0	naringenin	43,53	apoB	25,29	naringenin	apoB	MESH:C005273	338	Chemical	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Inhibition of hepatocyte apoB secretion by naringenin : enhanced rapid intracellular degradation independent of reduced microsomal cholesteryl_esters .
18587069	0	naringenin	73,83	apoB	14,18	naringenin	apoB	MESH:C005273	338	Chemical	Gene	amplified|nmod|START_ENTITY amplified|nsubjpass|Inhibition Inhibition|nmod|secretion secretion|amod|END_ENTITY	Inhibition of apoB secretion from HepG2 cells by insulin is amplified by naringenin , independent of the insulin_receptor .
18587069	0	naringenin	73,83	insulin_receptor	104,120	naringenin	insulin receptor	MESH:C005273	3643	Chemical	Gene	START_ENTITY|appos|independent independent|nmod|END_ENTITY	Inhibition of apoB secretion from HepG2 cells by insulin is amplified by naringenin , independent of the insulin_receptor .
20567977	0	naringenin	8,18	peroxisome_proliferators-activated_receptor_a	37,82	naringenin	peroxisome proliferators-activated receptor a	MESH:C005273	25747(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Dietary naringenin increases hepatic peroxisome_proliferators-activated_receptor_a protein expression and decreases plasma triglyceride and adiposity in rats .
27050864	0	naringin	23,31	FXR	112,115	naringin	FXR	MESH:C005274	60351(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|role role|nmod|END_ENTITY	Ameliorative effect of naringin in acetaminophen-induced hepatic_and_renal_toxicity in laboratory_rats : role of FXR and KIM-1 .
23639361	0	naringin	33,41	Ghrelin_receptor	0,16	naringin	Ghrelin receptor	MESH:C005274	2693	Chemical	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	Ghrelin_receptor is activated by naringin and naringenin , constituents of a prokinetic agent Poncirus fructus .
19323275	0	naringin	67,75	P-glycoprotein	38,52	naringin	P-glycoprotein	MESH:C005274	5243	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|expression expression|amod|END_ENTITY	Modulation of anticancer drug-induced P-glycoprotein expression by naringin .
23524668	0	natamycin	15,24	L10	119,122	natamycin	L10	MESH:D010866	6134	Chemical	Gene	production|compound|START_ENTITY Improvement|nmod|production chattanoogensis|nsubj|Improvement chattanoogensis|dobj|END_ENTITY	Improvement of natamycin production by engineering of phosphopantetheinyl transferases in Streptomyces chattanoogensis L10 .
25064840	0	natamycin	54,63	L10	109,112	natamycin	L10	MESH:D010866	28915	Chemical	Gene	biosynthesis|compound|START_ENTITY involved|nmod|biosynthesis involved|nmod|END_ENTITY	Characterization of type II thioesterases involved in natamycin biosynthesis in Streptomyces chattanoogensis L10 .
25724582	0	natamycin	41,50	L10	94,97	natamycin	L10	MESH:D010866	28915	Chemical	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Sigma factor WhiGch positively regulates natamycin production in Streptomyces chattanoogensis L10 .
25801968	0	natamycin	18,27	L10	120,123	natamycin	L10	MESH:D010866	28915	Chemical	Gene	Generation|nmod|START_ENTITY analogs|nsubj|Generation analogs|nmod|engineering engineering|nmod|genes genes|nmod|END_ENTITY	Generation of the natamycin analogs by gene engineering of natamycin biosynthetic genes in Streptomyces chattanoogensis L10 .
25801968	0	natamycin	59,68	L10	120,123	natamycin	L10	MESH:D010866	28915	Chemical	Gene	genes|amod|START_ENTITY genes|nmod|END_ENTITY	Generation of the natamycin analogs by gene engineering of natamycin biosynthetic genes in Streptomyces chattanoogensis L10 .
15005635	0	nateglinide	72,83	CYP2C9	13,19	nateglinide	CYP2C9	MESH:C060142	1559	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY polymorphisms|nmod|pharmacokinetics polymorphisms|nsubj|Influence Influence|nmod|END_ENTITY	Influence of CYP2C9 and CYP2D6 polymorphisms on the pharmacokinetics of nateglinide in genotyped healthy volunteers .
22842957	0	nateglinide	91,102	CYP2C9	10,16	nateglinide	CYP2C9	MESH:C060142	1559	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY polymorphisms|nmod|pharmacokinetics polymorphisms|nsubj|Effect Effect|nmod|END_ENTITY	Effect of CYP2C9 and SLCO1B1 polymorphisms on the pharmacokinetics and pharmacodynamics of nateglinide in healthy Chinese male volunteers .
17298589	0	nateglinide	37,48	Insulin	0,7	nateglinide	Insulin	MESH:C060142	3630	Chemical	Gene	diabetes|amod|START_ENTITY glargine|nmod|diabetes glargine|nsubj|END_ENTITY	Insulin glargine in combination with nateglinide in people with Type 2 diabetes : a randomized placebo-controlled trial .
12237260	0	nateglinide	24,35	MCT1	115,119	nateglinide	MCT1	MESH:C060142	6566	Chemical	Gene	Transport|nmod|START_ENTITY Transport|nmod|END_ENTITY	Transport and uptake of nateglinide in Caco-2 cells and its inhibitory effect on human monocarboxylate transporter MCT1 .
10748266	0	nateglinide	51,62	PEPT1	96,101	nateglinide	PEPT1	MESH:C060142	6564	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Inhibitory effect of novel oral hypoglycemic agent nateglinide -LRB- AY4166 -RRB- on peptide transporters PEPT1 and PEPT2 .
10720043	0	nateglinide	23,34	insulin	62,69	nateglinide	insulin	MESH:C060142	3630	Chemical	Gene	administration|compound|START_ENTITY effects|nmod|administration effects|nmod|secretion secretion|compound|END_ENTITY	Synergistic effects of nateglinide and meal administration on insulin secretion in patients with type_2_diabetes_mellitus .
10784228	0	nateglinide	44,55	insulin	59,66	nateglinide	insulin	MESH:C060142	3630	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Effects of the new oral hypoglycaemic agent nateglinide on insulin secretion in Type_2_diabetes_mellitus .
11200947	0	nateglinide	183,194	insulin	20,27	nateglinide	insulin	MESH:C060142	3630	Chemical	Gene	obese_type_2_diabetes|dep|START_ENTITY seen|nmod|obese_type_2_diabetes hyperglycemia|acl|seen responsible|nmod|hyperglycemia responsible|nsubj|Impairment Impairment|nmod|response response|compound|END_ENTITY	Impairment of early insulin response after glucose load , rather than insulin resistance , is responsible for postprandial hyperglycemia seen in obese_type_2_diabetes : assessment using nateglinide , a new insulin secretagogue .
11200947	0	nateglinide	183,194	insulin	202,209	nateglinide	insulin	MESH:C060142	3630	Chemical	Gene	START_ENTITY|appos|secretagogue secretagogue|compound|END_ENTITY	Impairment of early insulin response after glucose load , rather than insulin resistance , is responsible for postprandial hyperglycemia seen in obese_type_2_diabetes : assessment using nateglinide , a new insulin secretagogue .
11782867	0	nateglinide	36,47	insulin	90,97	nateglinide	insulin	MESH:C060142	3630	Chemical	Gene	tolerance|nmod|START_ENTITY Improvement|nmod|tolerance occurs|nsubj|Improvement occurs|nmod|enhancement enhancement|nmod|secretion secretion|compound|END_ENTITY	Improvement of glucose tolerance by nateglinide occurs through enhancement of early phase insulin secretion .
12965106	0	nateglinide	11,22	insulin	52,59	nateglinide	insulin	MESH:C060142	3630	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|nmod|END_ENTITY	Effects of nateglinide on the secretion of glycated insulin and glucose tolerance in type 2 diabetes .
14581145	0	nateglinide	65,76	insulin	15,22	nateglinide	insulin	MESH:C060142	3630	Chemical	Gene	secretagogue|appos|START_ENTITY resistance|nmod|secretagogue resistance|compound|END_ENTITY	Improvement of insulin resistance by a new insulin secretagogue , nateglinide -- analysis based on the homeostasis model .
14581145	0	nateglinide	65,76	insulin	43,50	nateglinide	insulin	MESH:C060142	3630	Chemical	Gene	secretagogue|appos|START_ENTITY secretagogue|compound|END_ENTITY	Improvement of insulin resistance by a new insulin secretagogue , nateglinide -- analysis based on the homeostasis model .
16214255	0	nateglinide	22,33	insulin	37,44	nateglinide	insulin	MESH:C060142	3630	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|resistance resistance|compound|END_ENTITY	Beneficial effects of nateglinide on insulin resistance in type 2 diabetes .
18474944	0	naveglitazar	70,82	PPAR_alpha	101,111	naveglitazar	PPAR alpha	MESH:C517861	25747(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Urothelial carcinogenesis in the urinary bladder of rats treated with naveglitazar , a gamma-dominant PPAR_alpha / gamma agonist : lack of evidence for urolithiasis as an inciting event .
20225994	0	nebicapone	22,32	catechol-O-methyltransferase	40,68	nebicapone	catechol-O-methyltransferase	MESH:C433466	1312	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Chronopharmacology of nebicapone , a new catechol-O-methyltransferase inhibitor .
16790555	0	nebicapone	20,30	catechol-o-methyltransferase	52,80	nebicapone	catechol-o-methyltransferase	MESH:C433466	1312	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Human metabolism of nebicapone -LRB- BIA_3-202 -RRB- , a novel catechol-o-methyltransferase inhibitor : characterization of in vitro glucuronidation .
12535855	0	nebivolol	35,44	Beta_1-adrenoceptor	0,19	nebivolol	Beta 1-adrenoceptor	MESH:C052753	153	Chemical	Gene	selectivity|nmod|START_ENTITY selectivity|amod|END_ENTITY	Beta_1-adrenoceptor selectivity of nebivolol and bisoprolol .
15492765	0	nebivolol	108,117	beta1-adrenoceptor	77,95	nebivolol	beta1-adrenoceptor	MESH:C052753	153	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Pharmacological mechanisms of clinically favorable properties of a selective beta1-adrenoceptor antagonist , nebivolol .
1970437	0	nebivolol	57,66	beta_1-adrenoceptor	25,44	nebivolol	beta 1-adrenoceptor	MESH:C052753	24925(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Effects of the selective beta_1-adrenoceptor antagonist , nebivolol , on cardiovascular parameters in the pithed normotensive rat .
23815535	0	nebivolol	11,20	renin	80,85	nebivolol	renin	MESH:C052753	5972	Chemical	Gene	blockade|amod|START_ENTITY blockade|compound|END_ENTITY	Effects of nebivolol on aortic compliance in patients with diabetes and maximal renin angiotensin system blockade : the EFFORT study .
23004677	0	nectandrin_B	21,33	AMPK	44,48	nectandrin B	AMPK	MESH:C524653	78975(Tax:10116)	Chemical	Gene	START_ENTITY|appos|activator activator|compound|END_ENTITY	Protective effect of nectandrin_B , a potent AMPK activator on neointima formation : inhibition of Pin1 expression through AMPK activation .
15675582	0	nedaplatin	37,47	NAF	100,103	nedaplatin	NAF	MESH:C053989	3576	Chemical	Gene	combination|nmod|START_ENTITY study|nmod|combination study|appos|END_ENTITY	-LSB- Phase I study of the combination of nedaplatin -LRB- NED -RRB- , adriamycin -LRB- ADM -RRB- , and 5-fluorouracil -LRB- 5-FU -RRB- -LRB- NAF -RRB- for treatment of unresectable advanced esophageal_cancer -RSB- .
1317231	0	nedocromil_sodium	21,38	GM-CSF	69,75	nedocromil sodium	GM-CSF	MESH:D017835	1437	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|release release|nmod|END_ENTITY	Protective effect of nedocromil_sodium on the IL1-induced release of GM-CSF from cultured human bronchial epithelial cells .
9760791	0	nedocromil_sodium	15,32	HRF	90,93	nedocromil sodium	HRF	MESH:D017835	7178	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	-LSB- The effect of nedocromil_sodium on spontaneous production of histamine_releasing_factor -LRB- HRF -RRB- by mononuclear blood cells in patients with nonatopic bronchial_asthma -RSB- .
9760791	0	nedocromil_sodium	15,32	histamine_releasing_factor	62,88	nedocromil sodium	histamine releasing factor	MESH:D017835	7178	Chemical	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	-LSB- The effect of nedocromil_sodium on spontaneous production of histamine_releasing_factor -LRB- HRF -RRB- by mononuclear blood cells in patients with nonatopic bronchial_asthma -RSB- .
11452702	0	nefazodone	31,41	P-glycoprotein	0,14	nefazodone	P-glycoprotein	MESH:C051752	5243	Chemical	Gene	interactions|nmod|START_ENTITY interactions|amod|END_ENTITY	P-glycoprotein interactions of nefazodone and trazodone in cell culture .
7475971	0	nefazodone	32,42	serotonin_transporter	56,77	nefazodone	serotonin transporter	MESH:C051752	25553(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	The serotonergic antidepressant nefazodone inhibits the serotonin_transporter : in vivo and ex vivo studies .
21678521	0	neferine	83,91	CYP1A2	33,39	neferine	CYP1A2	MESH:C057222	1544	Chemical	Gene	START_ENTITY|nsubj|inhibition inhibition|nmod|END_ENTITY	The in vitro inhibition of human CYP1A2 , CYP2D6 and CYP3A4 by tetrahydropalmatine , neferine and berberine .
18445137	0	nefiracetam	96,107	CA1	131,134	nefiracetam	CA1	MESH:C058876	310218(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|region region|compound|END_ENTITY	CaM kinase II and protein kinase C activations mediate enhancement of long-term potentiation by nefiracetam in the rat hippocampal CA1 region .
19096234	0	nefopam	115,122	transient_receptor_potential_vanilloid_subtype_1	16,64	nefopam	transient receptor potential vanilloid subtype 1	MESH:D009340	83810(Tax:10116)	Chemical	Gene	Contribution|nmod|START_ENTITY Contribution|nmod|END_ENTITY	Contribution of transient_receptor_potential_vanilloid_subtype_1 to the analgesic and antihyperalgesic activity of nefopam in rodents .
21697087	0	nelfinavir	99,109	DR5	81,84	nelfinavir	DR5	MESH:D019888	8795	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Modulation of CCAAT/enhancer _ binding_protein_homologous_protein -LRB- CHOP -RRB- - dependent DR5 expression by nelfinavir sensitizes glioblastoma multiforme cells to tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- .
19179444	0	nelfinavir	55,65	insulin	25,32	nelfinavir	insulin	MESH:D019888	3630	Chemical	Gene	induced|nmod|START_ENTITY resistance|acl|induced resistance|compound|END_ENTITY	Postreceptoral adipocyte insulin resistance induced by nelfinavir is caused by insensitivity of PKB/Akt to phosphatidylinositol-3 ,4,5 - trisphosphate .
10353635	0	neo-clerodane_diterpenoids	63,89	sPLA2	20,25	neo-clerodane diterpenoids	sPLA2	null	8399	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of human sPLA2 and 5-lipoxygenase activities by two neo-clerodane_diterpenoids .
22020647	0	neoagarobiose	137,150	Sco3487	51,58	neoagarobiose	Sco3487	MESH:C068544	1098924(Tax:100226)	Chemical	Gene	START_ENTITY|nsubj|characterization characterization|nmod|END_ENTITY	Identification and biochemical characterization of Sco3487 from Streptomyces_coelicolor_A3 -LRB- 2 -RRB- , an exo - and endo-type b-agarase-producing neoagarobiose .
23821348	0	neomycin	43,51	Bax	0,3	neomycin	Bax	MESH:D009355	58081(Tax:7955)	Chemical	Gene	regulate|dobj|START_ENTITY regulate|nsubj|END_ENTITY	Bax , Bcl2 , and p53 differentially regulate neomycin - and gentamicin-induced hair cell death in the zebrafish lateral line .
8290891	0	neopterin	28,37	Interferon-gamma	0,16	neopterin	Interferon-gamma	MESH:D019798	3458	Chemical	Gene	release|compound|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Interferon-gamma stimulates neopterin release from cultured kidney epithelial cells .
10841949	0	neopterin	21,30	THP-1	81,86	neopterin	THP-1	MESH:D019798	2736	Chemical	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Histamine suppresses neopterin production in the human myelomonocytoma cell line THP-1 .
23564066	1	neopterin	161,170	THP-1	223,228	neopterin	THP-1	MESH:D019798	2736	Chemical	Gene	effects|nmod|START_ENTITY investigate|dobj|effects investigate|nmod|expression expression|nmod|cells cells|compound|END_ENTITY	To investigate the effects of neopterin on ABCA1 expression and cholesterol efflux in human THP-1 macrophage-derived foam cells , and to explore the role of the liver X receptor alpha -LRB- LXRa -RRB- involved .
10359064	0	neopterin	11,20	erythropoietin	71,85	neopterin	erythropoietin	MESH:D019798	2056	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|production production|compound|END_ENTITY	Effects of neopterin and 7,8-dihydroneopterin on hypoxia-induced renal erythropoietin production .
16134219	0	neopterin	120,129	interleukin-2	66,79	neopterin	interleukin-2	MESH:D019798	3558	Chemical	Gene	rise|nmod|START_ENTITY accompanied|nmod|rise accompanied|nsubjpass|Neopterin Neopterin|nmod|renal_cell_carcinoma renal_cell_carcinoma|dep|administration administration|nmod|END_ENTITY	Neopterin in renal_cell_carcinoma : inhalational administration of interleukin-2 is not accompanied by a rise of urinary neopterin .
8110731	0	neopterin	38,47	interleukin-2	103,116	neopterin	interleukin-2	MESH:D019798	3558	Chemical	Gene	production|compound|START_ENTITY production|nmod|administration administration|nmod|END_ENTITY	Increased systemic , but not regional , neopterin production following intraperitoneal administration of interleukin-2 and lack of effect of pterins upon the lymphokine-activated killer cell phenomenon .
8553904	0	neopterin	49,58	interleukin-2	75,88	neopterin	interleukin-2	MESH:D019798	3558	Chemical	Gene	levels|nmod|START_ENTITY Correlation|nmod|levels Correlation|nmod|immunotherapy immunotherapy|compound|END_ENTITY	Correlation between pretreatment serum levels of neopterin and response to interleukin-2 immunotherapy in cancer patients .
9045386	0	neopterin	73,82	interleukin-2	84,97	neopterin	interleukin-2	MESH:D019798	3558	Chemical	Gene	receptors|compound|START_ENTITY receptors|dep|END_ENTITY	-LSB- Activation of cellular immunity in Wegener 's _ granulomatosis : a study of neopterin , interleukin-2 receptors and tumor necrosis factor -RSB- .
15642275	0	neopterin	6,15	tumor_necrosis_factor-alpha	17,44	neopterin	tumor necrosis factor-alpha	MESH:D019798	7124	Chemical	Gene	START_ENTITY|appos|levels levels|amod|END_ENTITY	Serum neopterin , tumor_necrosis_factor-alpha and soluble tumor necrosis factor receptor II -LRB- p75 -RRB- levels and disease activity in Egyptian female patients with systemic_lupus_erythematosus .
26706112	0	neorauflavane	36,49	tyrosinase	14,24	neorauflavane	tyrosinase	null	7299	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Highly potent tyrosinase inhibitor , neorauflavane from Campylotropis hirtella and inhibitory mechanism with molecular docking .
23896689	0	neoruscogenin	42,55	RORa	133,137	neoruscogenin	RORa	MESH:C012452	6095	Chemical	Gene	identification|nmod|START_ENTITY identification|nmod|END_ENTITY	The identification of naturally occurring neoruscogenin as a bioavailable , potent , and high-affinity agonist of the nuclear receptor RORa -LRB- NR1F1 -RRB- .
1547059	0	neostigmine	11,22	acetylcholinesterase	60,80	neostigmine	acetylcholinesterase	MESH:D009388	43	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|compound|END_ENTITY	Effects of neostigmine and edrophonium on human erythrocyte acetylcholinesterase activity .
19844573	0	nephronectin	27,39	miR-378	9,16	nephronectin	miR-378	null	723889(Tax:10090)	Chemical	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	MicroRNA miR-378 regulates nephronectin expression modulating osteoblast differentiation by targeting GalNT-7 .
9283721	0	nepicastat	36,46	dopamine-beta-hydroxylase	106,131	nepicastat	dopamine-beta-hydroxylase	MESH:C109487	1621	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|inhibitor inhibitor|nmod|END_ENTITY	Catecholamine modulatory effects of nepicastat -LRB- RS-25560-197 -RRB- , a novel , potent and selective inhibitor of dopamine-beta-hydroxylase .
23561307	0	nepicastat	38,48	dopamine_b-hydroxylase	4,26	nepicastat	dopamine b-hydroxylase	MESH:C109487	25699(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	The dopamine_b-hydroxylase inhibitor , nepicastat , suppresses chocolate self-administration and reinstatement of chocolate seeking in rats .
11034950	0	nepicastat	53,63	dopamine_beta-hydroxylase	11,36	nepicastat	dopamine beta-hydroxylase	MESH:C109487	448806(Tax:9615)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Effects of dopamine_beta-hydroxylase inhibition with nepicastat on the progression of left_ventricular_dysfunction and remodeling in dogs with chronic_heart_failure .
8758695	0	neuromedin_C	11,23	gastrin	27,34	neuromedin C	gastrin	MESH:C040794	25320(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	-LSB- Effect of neuromedin_C on gastrin secretion from isolated and perfused rat stomach -RSB- .
22933024	11	neuronostatin	1846,1859	GPR107	1801,1807	neuronostatin	GPR107	null	311857(Tax:10116)	Chemical	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	Thus , GPR107 is a promising candidate receptor for neuronostatin , and neuronostatin , interacting with GPR107 , may play an important role in the central control of cardiovascular function .
24854458	0	niacin	10,16	FGF23	20,25	niacin	FGF23	MESH:D009525	8074	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|concentration concentration|compound|END_ENTITY	Effect of niacin on FGF23 concentration in chronic_kidney_disease .
15580557	0	niacin	55,61	HM74	20,24	niacin	HM74	MESH:D009525	8843	Chemical	Gene	START_ENTITY|nsubj|Variations Variations|nmod|END_ENTITY	Variations in human HM74 -LRB- GPR109B -RRB- and HM74A -LRB- GPR109A -RRB- niacin receptors .
17395297	0	niacin	10,16	LXRalpha	20,28	niacin	LXRalpha	MESH:D009525	100352900(Tax:9986)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of niacin on LXRalpha and PPARgamma expression and HDL-induced cholesterol efflux in adipocytes of hypercholesterolemic_rabbits .
16887123	0	niacin	17,23	adiponectin	31,42	niacin	adiponectin	MESH:D009525	9370	Chemical	Gene	raises|nsubj|START_ENTITY raises|dobj|END_ENTITY	Extended-release niacin raises adiponectin and leptin .
19707470	0	niacin	27,33	hormone-sensitive_lipase	37,61	niacin	hormone-sensitive lipase	MESH:D009525	3991	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of extended-release niacin on hormone-sensitive_lipase and lipoprotein_lipase in patients with HIV-associated_lipodystrophy_syndrome .
18402819	0	niacin	10,16	leptin	30,36	niacin	leptin	MESH:D009525	100008747(Tax:9986)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of niacin on adipocyte leptin in hypercholesterolemic_rabbits .
1284083	0	niacin	11,17	myeloperoxidase	52,67	niacin	myeloperoxidase	MESH:D009525	4353	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of niacin on bleomycin-induced increases in myeloperoxidase , prolyl hydroxylase , and superoxide dismutase activities and collagen accumulation in the lungs of hamsters .
2888466	0	niacin	22,28	ornithine_decarboxylase	63,86	niacin	ornithine decarboxylase	MESH:D009525	24609(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activity activity|amod|END_ENTITY	Inhibitory effects of niacin and its analogues on induction of ornithine_decarboxylase activity by diethylnitrosamine in rat liver .
15672751	0	nicardipine	58,69	cyp2b	21,26	nicardipine	cyp2b	MESH:D009529	13094(Tax:10090)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of hepatic cyp2b and cyp3a subfamily enzymes by nicardipine and nifedipine in mice .
11131046	0	nicardipine	10,21	endothelin-1	49,61	nicardipine	endothelin-1	MESH:D009529	1906	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of nicardipine versus enalapril on plasma endothelin-1 in hypertensive patients with type_2_diabetes_mellitus .
2473306	0	nicardipine	60,71	endothelin-1	16,28	nicardipine	endothelin-1	MESH:D009529	24323(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY Pharmacology|dep|effect Pharmacology|nmod|END_ENTITY	Pharmacology of endothelin-1 in isolated vessels : effect of nicardipine , methylene_blue , hemoglobin , and gossypol .
2645144	0	nicardipine	10,21	insulin	25,32	nicardipine	insulin	MESH:D009529	3630	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Effect of nicardipine on insulin secretion , glucose and lipid metabolism in hypertensive , non-insulin dependent diabetics .
3154642	0	nicardipine	18,29	insulin	77,84	nicardipine	insulin	MESH:D009529	3630	Chemical	Gene	Lack|nmod|START_ENTITY Lack|nmod|release release|compound|END_ENTITY	Lack of effect of nicardipine and diltiazem on glucose - and arginine-induced insulin release in obese subjects .
3896283	0	nicardipine	14,25	insulin	57,64	nicardipine	insulin	MESH:D009529	3630	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|compound|END_ENTITY	The effect of nicardipine on glucose and drug-stimulated insulin secretion in normal volunteers .
9507135	0	nicardipine	10,21	pyruvate_dehydrogenase	50,72	nicardipine	pyruvate dehydrogenase	MESH:D009529	54704	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effect of nicardipine , a Ca2 + channel blocker , on pyruvate_dehydrogenase activity and energy metabolites during cerebral_ischemia and reperfusion in gerbil brain .
8971425	0	nicergoline	41,52	CYP2D6	15,21	nicergoline	CYP2D6	MESH:D009530	1565	Chemical	Gene	metabolism|amod|START_ENTITY Involvement|nmod|metabolism Involvement|nmod|END_ENTITY	Involvement of CYP2D6 but not CYP2C19 in nicergoline metabolism in humans .
21814687	0	nickel	41,47	CO2	13,16	nickel	CO2	MESH:D009532	717	Chemical	Gene	Reduction|nmod|START_ENTITY Reduction|nmod|END_ENTITY	Reduction of CO2 and SO2 with low valent nickel compounds under mild conditions .
17044645	0	nickel	41,47	FHIT	15,19	nickel	FHIT	MESH:D009532	2272	Chemical	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Alterations of FHIT gene and P16 gene in nickel transformed human bronchial epithelial cells .
23536762	0	nickel	21,27	GADD45a	0,7	nickel	GADD45a	MESH:D009532	13197(Tax:10090)	Chemical	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	GADD45a induction by nickel negatively regulates JNKs/p38 activation via promoting PP2Ca expression .
23139401	0	nickel	107,113	HH0418	91,97	nickel	HH0418	MESH:D009532	1493472(Tax:235279)	Chemical	Gene	proteins|compound|START_ENTITY proteins|compound|END_ENTITY	Helicobacter_hepaticus NikR controls urease and hydrogenase activities via the NikABDE and HH0418 putative nickel import proteins .
4357307	0	nickel	49,55	Prolactin	0,9	nickel	Prolactin	MESH:D009532	5617	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubj|secretion secretion|compound|END_ENTITY	Prolactin secretion is specifically inhibited by nickel .
25285530	0	nickel	37,43	SCO4226	24,31	nickel	SCO4226	MESH:D009532	1099666(Tax:100226)	Chemical	Gene	protein|amod|START_ENTITY protein|nsubj|END_ENTITY	Streptomyces_coelicolor SCO4226 is a nickel binding protein .
20711192	0	nickel	85,91	Toll-like_receptor_4	23,43	nickel	Toll-like receptor 4	MESH:D009532	7099	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Crucial role for human Toll-like_receptor_4 in the development of contact allergy to nickel .
2382268	0	nickel	11,17	catalase	21,29	nickel	catalase	MESH:D009532	24248(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|amod|END_ENTITY	Effects of nickel on catalase activity in vitro and in vivo .
19505905	0	nickel	11,17	cyclin	21,27	nickel	cyclin	MESH:D009532	5111	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of nickel on cyclin expression , cell cycle progression and cell proliferation in human pulmonary cells .
6090848	0	nickel	56,62	prolactin	14,23	nickel	prolactin	MESH:D009532	24683(Tax:10116)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of prolactin and growth_hormone secretion by nickel .
15696600	0	nickel	36,42	prolidase	14,23	nickel	prolidase	MESH:D009532	5184	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Inhibition of prolidase activity by nickel causes decreased growth of proline auxotrophic CHO cells .
18966751	0	nickel_hexacyanoferrate	89,112	alcohol_dehydrogenase	62,83	nickel hexacyanoferrate	alcohol dehydrogenase	null	10327	Chemical	Gene	biosensor|nmod|START_ENTITY biosensor|nmod|END_ENTITY	Amperometric biosensor for ethanol based on immobilization of alcohol_dehydrogenase on a nickel_hexacyanoferrate modified microband gold electrode .
22799185	0	niclosamide	28,39	snail	11,16	niclosamide	snail	MESH:D009534	6615	Chemical	Gene	control|nmod|START_ENTITY control|compound|END_ENTITY	-LSB- Effect of snail control of niclosamide by soil mixing and spraying methods in high dam of terrace -RSB- .
25320353	0	nicorandil	34,44	ACE	15,18	nicorandil	ACE	MESH:D020108	24310(Tax:10116)	Chemical	Gene	inhibitor|nmod|START_ENTITY inhibitor|compound|END_ENTITY	Combination of ACE inhibitor with nicorandil provides further protection in chronic_kidney_disease .
21858735	0	nicorandil	11,21	BNP	42,45	nicorandil	BNP	MESH:D020108	4879	Chemical	Gene	START_ENTITY|nmod|reduction reduction|nmod|END_ENTITY	Effects of nicorandil on the reduction of BNP levels in patients with chronic_kidney_disease .
24642889	0	nicorandil	74,84	COX-2	46,51	nicorandil	COX-2	MESH:D020108	26198(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY expression|acl|induced expression|compound|END_ENTITY	GATA-4 transcription factor regulates cardiac COX-2 expression induced by nicorandil in left ventricle of rats .
18019273	0	nicorandil	12,22	endothelin-1	69,81	nicorandil	endothelin-1	MESH:D020108	396915(Tax:9823)	Chemical	Gene	preserves|nsubj|START_ENTITY preserves|advcl|decreasing decreasing|dobj|END_ENTITY	Intravenous nicorandil preserves endothelial junctions by decreasing endothelin-1 via activation of ATP-sensitive K + channel .
10625484	0	nicotinamide	12,24	3_alpha-hydroxysteroid_dehydrogenase	54,90	nicotinamide	3 alpha-hydroxysteroid dehydrogenase	MESH:D009536	291283(Tax:10116)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Mutation of nicotinamide pocket residues in rat liver 3_alpha-hydroxysteroid_dehydrogenase reveals different modes of cofactor binding .
6282138	4	nicotinamide	831,843	NAD	902,905	nicotinamide	PTH	MESH:D009536	24694(Tax:10116)	Chemical	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	Administration of nicotinamide to rats fed a low phosphate diet increased renal cortical NAD levels , increased phosphate excretion , partially restored the phosphaturic effect of PTH and DBcAMP , and completely restored the phosphaturic response to calcitonin .
22311271	0	nicotinamide	148,160	PARP-1	181,187	nicotinamide	PARP-1	MESH:D009536	25591(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activity activity|compound|END_ENTITY	Further studies on the hypothesis of PARP-1 inhibition as a strategy for lessening the long-term effects produced by perinatal asphyxia : effects of nicotinamide and theophylline on PARP-1 activity in brain and peripheral tissue : nicotinamide and theophylline on PARP-1 activity .
22311271	0	nicotinamide	230,242	PARP-1	263,269	nicotinamide	PARP-1	MESH:D009536	25591(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Further studies on the hypothesis of PARP-1 inhibition as a strategy for lessening the long-term effects produced by perinatal asphyxia : effects of nicotinamide and theophylline on PARP-1 activity in brain and peripheral tissue : nicotinamide and theophylline on PARP-1 activity .
26660162	0	nicotinamide	21,33	SIRT1	4,9	nicotinamide	SIRT1	MESH:D009536	23411	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	The SIRT1 inhibitor , nicotinamide , inhibits hepatitis_B virus replication in vitro and in vivo .
12899610	0	nicotinamide	19,31	Sir2	0,4	nicotinamide	Sir2	MESH:D009536	93759(Tax:10090)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Sir2 regulation by nicotinamide results from switching between base exchange and deacetylation chemistry .
14522996	0	nicotinamide	13,25	Sir2	63,67	nicotinamide	Sir2	MESH:D009536	22933	Chemical	Gene	inhibition|amod|START_ENTITY Mechanism|nmod|inhibition Mechanism|nmod|deacetylases deacetylases|amod|END_ENTITY	Mechanism of nicotinamide inhibition and transglycosidation by Sir2 histone/protein deacetylases .
15150415	0	nicotinamide	21,33	Sir2	87,91	nicotinamide	Sir2	MESH:D009536	23411	Chemical	Gene	cleavage|nmod:npmod|START_ENTITY basis|nmod|cleavage basis|dep|END_ENTITY	Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD -LRB- + -RRB- - dependent Sir2 histone/protein deacetylases .
15780941	0	nicotinamide	35,47	Sir2	98,102	nicotinamide	Sir2	MESH:D009536	23411	Chemical	Gene	inhibition|nmod|START_ENTITY altering|nmod|inhibition altering|dobj|specificity specificity|nmod|enzyme enzyme|amod|END_ENTITY	Mechanism of sirtuin inhibition by nicotinamide : altering the NAD -LRB- + -RRB- cosubstrate specificity of a Sir2 enzyme .
6218725	0	nicotinamide	14,26	TRH	82,85	nicotinamide	TRH	MESH:D009536	25569(Tax:10116)	Chemical	Gene	Protection|nmod|START_ENTITY Protection|nmod|END_ENTITY	Protection by nicotinamide against streptozotocin-induced reduction in pancreatic TRH .
16200840	0	nicotinamide	34,46	insulin	61,68	nicotinamide	insulin	MESH:D009536	3630	Chemical	Gene	therapy|compound|START_ENTITY therapy|compound|END_ENTITY	A two year observational study of nicotinamide and intensive insulin therapy in patients with recent onset type_1_diabetes_mellitus .
1347751	0	nicotinamide	22,34	intercellular_adhesion_molecule-1	81,114	nicotinamide	intercellular adhesion molecule-1	MESH:D009536	3383	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Inhibitory effects of nicotinamide on recombinant human interferon-gamma-induced intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- and HLA-DR antigen expression on cultured human endothelial cells .
7903279	0	nicotinamide	22,34	intercellular_adhesion_molecule-1	38,71	nicotinamide	intercellular adhesion molecule-1	MESH:D009536	3383	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|amod|END_ENTITY	Inhibitory effects of nicotinamide on intercellular_adhesion_molecule-1 expression on cultured human thyroid cells .
22207684	0	nicotinamide	36,48	sirtuin_2	12,21	nicotinamide	sirtuin 2	MESH:D009536	22933	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	The role of sirtuin_2 activation by nicotinamide phosphoribosyltransferase in the aberrant proliferation and survival of myeloid_leukemia cells .
7616299	0	nicotinamide	8,20	xanthine_oxidoreductase	47,70	nicotinamide	xanthine oxidoreductase	MESH:D009536	497811(Tax:10116)	Chemical	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	Dietary nicotinamide supplementation increases xanthine_oxidoreductase activity in the kidney and heart but not liver of obese Zucker rats .
9574519	0	nicotinamide_adenine_dinucleotide	76,109	ADP-ribosyltransferase	14,36	nicotinamide adenine dinucleotide	ADP-ribosyltransferase	MESH:D009243	11870(Tax:10090)	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of ADP-ribosyltransferase on normal T lymphocytes and effects of nicotinamide_adenine_dinucleotide on their function .
3790494	0	nicotinamide_adenine_dinucleotide	13,46	CC-1065	122,129	nicotinamide adenine dinucleotide	CC-1065	MESH:D009243	940519(Tax:190650)	Chemical	Gene	Depletion|nmod|START_ENTITY Depletion|nmod|END_ENTITY	Depletion of nicotinamide_adenine_dinucleotide in normal and xeroderma_pigmentosum fibroblast cells by the antitumor drug CC-1065 .
11090977	0	nicotinamide_adenine_dinucleotide_phosphate	35,78	Fos	0,3	nicotinamide adenine dinucleotide phosphate	Fos	MESH:D009249	314322(Tax:10116)	Chemical	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Fos activation and upregulation of nicotinamide_adenine_dinucleotide_phosphate diaphorase in the rat pituitary by acute capsaicin injection .
19022160	0	nicotinamide_adenine_dinucleotide_phosphate	23,66	NOX5	18,22	nicotinamide adenine dinucleotide phosphate	NOX5	MESH:D009249	79400	Chemical	Gene	oxidase|compound|START_ENTITY oxidase|compound|END_ENTITY	Calcium-dependent NOX5 nicotinamide_adenine_dinucleotide_phosphate oxidase contributes to vascular oxidative stress in human coronary_artery_disease .
9585526	0	nicotinamide_adenine_dinucleotide_phosphate	84,127	Rac1	49,53	nicotinamide adenine dinucleotide phosphate	Rac1	MESH:D009249	5879	Chemical	Gene	activation|nmod|START_ENTITY involved|nmod|activation END_ENTITY|acl|involved	Mutational analysis of novel effector domains in Rac1 involved in the activation of nicotinamide_adenine_dinucleotide_phosphate -LRB- reduced -RRB- oxidase .
17445342	0	nicotinamide_adenine_dinucleotide_phosphate	58,101	p22phox	38,45	nicotinamide adenine dinucleotide phosphate	p22phox	MESH:D009249	1535	Chemical	Gene	oxidase|amod|START_ENTITY subunit|nmod|oxidase subunit|amod|END_ENTITY	Polymorphism C242T of the gene of the p22phox subunit for nicotinamide_adenine_dinucleotide_phosphate oxidase , and erythrocytic antioxidant enzymes , in patients with tetralogy_of_Fallot .
19567155	0	nicotinamide_adenine_dinucleotide_phosphate	29,72	p22phox	89,96	nicotinamide adenine dinucleotide phosphate	p22phox	MESH:D009249	1535	Chemical	Gene	oxidase|compound|START_ENTITY Relationship|nmod|oxidase subunit|nsubj|Relationship subunit|dobj|polymorphism polymorphism|amod|END_ENTITY	Relationship between reduced nicotinamide_adenine_dinucleotide_phosphate oxidase subunit p22phox gene polymorphism and obstructive_sleep_apnea-hypopnea_syndrome in the Chinese Han population .
22613645	0	nicotinamide_adenine_dinucleotide_phosphate	15,58	p22phox	67,74	nicotinamide adenine dinucleotide phosphate	p22phox	MESH:D009249	1535	Chemical	Gene	oxidase|amod|START_ENTITY gene|amod|oxidase gene|amod|END_ENTITY	Association of nicotinamide_adenine_dinucleotide_phosphate oxidase p22phox gene 549C > T polymorphism with coronary_artery_disease .
25572489	0	nicotinamide_adenine_dinucleotide_phosphate	24,67	p22phox	76,83	nicotinamide adenine dinucleotide phosphate	p22phox	MESH:D009249	1535	Chemical	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Association between the nicotinamide_adenine_dinucleotide_phosphate oxidase p22phox gene - A930G polymorphism and intracerebral_hemorrhage .
26591766	0	nicotinamide_adenine_dinucleotide_phosphate	95,138	p22phox	155,162	nicotinamide adenine dinucleotide phosphate	p22phox	MESH:D009249	1535	Chemical	Gene	C242T|compound|START_ENTITY C242T|amod|END_ENTITY	-LSB- Interaction of polymorphisms of monocyte_chemoattractant_protein-1_receptor CCR2 gene 190A/G , nicotinamide_adenine_dinucleotide_phosphate oxidase subunit p22phox gene C242T and cigarette smoking increases the risk of nonalcoholic_fatty_liver_disease -RSB- .
11319715	0	nicotinamide_adenine_dinucleotide_phosphate	61,104	p47	46,49	nicotinamide adenine dinucleotide phosphate	p47	MESH:D009249	5341	Chemical	Gene	oxidase|amod|START_ENTITY subunit|nmod|oxidase subunit|amod|END_ENTITY	Acute suppressive effect of hydrocortisone on p47 subunit of nicotinamide_adenine_dinucleotide_phosphate oxidase .
22086006	0	nicotinamide_mononucleotide	10,37	PDX-1	83,88	nicotinamide mononucleotide	PDX-1	MESH:D009537	29535(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of nicotinamide_mononucleotide on insulin secretion and gene expressions of PDX-1 and FoxO1 in RIN-m5f cells .
4317722	0	nicotinamide_nucleotides	25,49	lactoperoxidase	90,105	nicotinamide nucleotides	lactoperoxidase	CHEBI:25527	4025	Chemical	Gene	oxidation|nmod|START_ENTITY oxidation|nmod|END_ENTITY	The oxidation of reduced nicotinamide_nucleotides by hydrogen_peroside in the presence of lactoperoxidase and thiocyanate , iodide or bromide .
20117937	0	nicotinamides	16,29	monoamine_oxidase_a	54,73	nicotinamides	monoamine oxidase a	null	4128	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Design of novel nicotinamides as potent and selective monoamine_oxidase_a inhibitors .
10670425	0	nicotine	22,30	5-HT1A	73,79	nicotine	5-HT1A	MESH:D009538	3350	Chemical	Gene	effects|nmod|START_ENTITY mediated|nsubjpass|effects mediated|nmod|END_ENTITY	Anxiogenic effects of nicotine in the dorsal hippocampus are mediated by 5-HT1A and not by muscarinic M1 receptors .
11029650	0	nicotine	68,76	5-HT1A	12,18	nicotine	5-HT1A	MESH:D009538	24473(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|receptors receptors|nummod|END_ENTITY	The role of 5-HT1A receptors in mediating the anxiogenic effects of nicotine following lateral septal administration .
12511591	0	nicotine	24,32	Akt	6,9	nicotine	Akt	MESH:D009538	11651(Tax:10090)	Chemical	Gene	activation|nmod|START_ENTITY END_ENTITY|acl|activation	Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells .
21232579	0	nicotine	67,75	BDNF	15,19	nicotine	BDNF	MESH:D009538	12064(Tax:10090)	Chemical	Gene	treatment|compound|START_ENTITY levels|nmod|treatment levels|amod|END_ENTITY	Alterations in BDNF and phospho-CREB levels following chronic oral nicotine treatment and its withdrawal in dopaminergic brain areas of mice .
12858318	0	nicotine	71,79	C-reactive_protein	0,18	nicotine	C-reactive protein	MESH:D009538	1401	Chemical	Gene	abstinence|compound|START_ENTITY smokers|nmod|abstinence mood|nmod|smokers mood|amod|END_ENTITY	C-reactive_protein and depressed mood in a sub-group of smokers during nicotine abstinence .
11749838	0	nicotine	99,107	CA1	123,126	nicotine	CA1	MESH:D009538	310218(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nmod|region region|compound|END_ENTITY	Activation of p42/44 mitogen-activated protein kinase pathway in long-term potentiation induced by nicotine in hippocampal CA1 region in rats .
20331564	0	nicotine	133,141	CB1	77,80	nicotine	CB1	MESH:D009538	25248(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY receptors|nmod|effects receptors|nummod|END_ENTITY	A second-order schedule of food reinforcement in rats to examine the role of CB1 receptors in the reinforcement-enhancing effects of nicotine .
21995552	0	nicotine	80,88	CB1	31,34	nicotine	CB1	MESH:D009538	12801(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY mediate|dobj|effects mediate|nsubj|receptors receptors|compound|END_ENTITY	Dorsal hippocampal cannabinoid CB1 receptors mediate the interactive effects of nicotine and ethanol on passive avoidance learning in mice .
2481202	0	nicotine	61,69	CCK	14,17	nicotine	CCK	MESH:D009538	25298(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of CCK or carbachol-stimulated amylase release by nicotine .
20843956	0	nicotine	54,62	CD25	121,125	nicotine	CD25	MESH:D009538	16184(Tax:10090)	Chemical	Gene	capacity|compound|START_ENTITY capacity|nmod|END_ENTITY	Stimulation of a7 nicotinic acetylcholine receptor by nicotine increases suppressive capacity of naturally occurring CD4 + CD25 + regulatory T cells in mice in vitro .
19693267	0	nicotine	102,110	CHRNA4	121,127	nicotine	CHRNA4	MESH:D009538	1137	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor -LRB- CHRNA4 -RRB- gene .
26440539	0	nicotine	96,104	CHRNA4	73,79	nicotine	CHRNA4	MESH:D009538	1137	Chemical	Gene	dependence|compound|START_ENTITY associated|nmod|dependence END_ENTITY|acl|associated	Genome-wide meta-analysis reveals common splice site acceptor variant in CHRNA4 associated with nicotine dependence .
18519132	0	nicotine	18,26	CHRNA5	41,47	nicotine	CHRNA5	MESH:D009538	1138	Chemical	Gene	dependence|compound|START_ENTITY dependence|nmod|END_ENTITY	A risk allele for nicotine dependence in CHRNA5 is a protective allele for cocaine_dependence .
17548664	0	nicotine	71,79	COMT	15,19	nicotine	COMT	MESH:D009538	1312	Chemical	Gene	trial|compound|START_ENTITY cessation|nmod|trial genotype|nmod|cessation genotype|nsubj|Association Association|nmod|Val108/158Met Val108/158Met|amod|END_ENTITY	Association of COMT Val108/158Met genotype with smoking cessation in a nicotine replacement therapy randomized trial .
22695756	0	nicotine	83,91	COMT	26,30	nicotine	COMT	MESH:D009538	1312	Chemical	Gene	therapy|compound|START_ENTITY END_ENTITY|nmod|therapy	Association of functional COMT Val108/Met polymorphism with smoking cessation in a nicotine replacement therapy .
23459442	0	nicotine	61,69	COMT	0,4	nicotine	COMT	MESH:D009538	1312	Chemical	Gene	modulates|nmod|START_ENTITY modulates|nsubj|Val158Met Val158Met|compound|END_ENTITY	COMT Val158Met modulates subjective responses to intravenous nicotine and cognitive performance in abstinent smokers .
26096691	0	nicotine	86,94	COMT	0,4	nicotine	COMT	MESH:D009538	1312	Chemical	Gene	modulates|nmod|START_ENTITY modulates|nsubj|polymorphism polymorphism|compound|END_ENTITY	COMT polymorphism modulates the resting-state EEG alpha oscillatory response to acute nicotine in male non-smokers .
26555332	0	nicotine	110,118	COMT	50,54	nicotine	COMT	MESH:D009538	1312	Chemical	Gene	treatment|nmod|START_ENTITY treatment|dep|Association Association|nmod|catechol-O-methyltransferase catechol-O-methyltransferase|appos|END_ENTITY	Association between catechol-O-methyltransferase -LRB- COMT -RRB- Val/Met genotype and smoking cessation treatment with nicotine : a meta-analysis .
9764926	0	nicotine	33,41	CYP1A1	23,29	nicotine	CYP1A1	MESH:D009538	24296(Tax:10116)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of pulmonary CYP1A1 by nicotine .
10376647	0	nicotine	21,29	CYP2A6	0,6	nicotine	CYP2A6	MESH:D009538	1548	Chemical	Gene	polymorphism|appos|START_ENTITY polymorphism|compound|END_ENTITY	CYP2A6 polymorphism , nicotine , and environmental nitrosamines .
10448083	0	nicotine	54,62	CYP2A6	102,108	nicotine	CYP2A6	MESH:D009538	1548	Chemical	Gene	metabolism|compound|START_ENTITY deletion|nmod|metabolism significance|nmod|deletion significance|dep|method method|nmod|END_ENTITY	The significance of the homozygous CYP2A6 deletion on nicotine metabolism : a new genotyping method of CYP2A6 using a single PCR-RFLP .
10448083	0	nicotine	54,62	CYP2A6	35,41	nicotine	CYP2A6	MESH:D009538	1548	Chemical	Gene	metabolism|compound|START_ENTITY deletion|nmod|metabolism deletion|compound|END_ENTITY	The significance of the homozygous CYP2A6 deletion on nicotine metabolism : a new genotyping method of CYP2A6 using a single PCR-RFLP .
10668854	0	nicotine	34,42	CYP2A6	86,92	nicotine	CYP2A6	MESH:D009538	1548	Chemical	Gene	formation|nmod|START_ENTITY attributed|nsubjpass|formation attributed|nmod|deletion deletion|nmod|gene gene|compound|END_ENTITY	Deficient cotinine formation from nicotine is attributed to the whole deletion of the CYP2A6 gene in humans .
11159795	0	nicotine	112,120	CYP2A6	50,56	nicotine	CYP2A6	MESH:D009538	1548	Chemical	Gene	metabolism|compound|START_ENTITY differences|nmod|metabolism implications|nmod|differences polymorphisms|dep|implications polymorphisms|nmod|gene gene|appos|END_ENTITY	Genetic polymorphisms in the cytochrome_P450_2A6 -LRB- CYP2A6 -RRB- gene : implications for interindividual differences in nicotine metabolism .
12024803	0	nicotine	39,47	CYP2A6	29,35	nicotine	CYP2A6	MESH:D009538	1548	Chemical	Gene	metabolism|compound|START_ENTITY Effects|nmod|metabolism Effects|nmod|deletion deletion|nmod|END_ENTITY	Effects of whole deletion of CYP2A6 on nicotine metabolism in humans .
12445030	0	nicotine	60,68	CYP2A6	31,37	nicotine	CYP2A6	MESH:D009538	1548	Chemical	Gene	metabolism|nummod|START_ENTITY causing|dobj|metabolism gene|acl|causing gene|compound|END_ENTITY	Genetic polymorphisms in human CYP2A6 gene causing impaired nicotine metabolism .
12445030	4	nicotine	755,763	CYP2A6	800,806	nicotine	CYP2A6	MESH:D009538	1548	Chemical	Gene	metabolism|compound|START_ENTITY ascribed|nsubjpass|metabolism ascribed|nmod|alleles alleles|nummod|END_ENTITY	The purpose of the present study was to clarify whether the impaired nicotine metabolism can be ascribed to these CYP2A6 alleles .
12487152	0	nicotine	31,39	CYP2A6	86,92	nicotine	CYP2A6	MESH:D009538	1548	Chemical	Gene	metabolism|compound|START_ENTITY differences|nmod|metabolism differences|nmod|END_ENTITY	Interindividual differences in nicotine metabolism and genetic polymorphisms of human CYP2A6 .
14974084	0	nicotine	2,10	CYP2A6	27,33	nicotine	CYP2A6	MESH:D009538	1548	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A nicotine C-oxidase gene -LRB- CYP2A6 -RRB- polymorphism important for promoter activity .
15247629	0	nicotine	47,55	CYP2A6	67,73	nicotine	CYP2A6	MESH:D009538	1548	Chemical	Gene	C-oxidase|compound|START_ENTITY C-oxidase|appos|END_ENTITY	Polymorphic NF-Y dependent regulation of human nicotine C-oxidase -LRB- CYP2A6 -RRB- .
15265511	0	nicotine	21,29	CYP2A6	48,54	nicotine	CYP2A6	MESH:D009538	1548	Chemical	Gene	START_ENTITY|nmod|subjects subjects|acl:relcl|deleted deleted|nsubjpass|gene gene|amod|END_ENTITY	Metabolic profile of nicotine in subjects whose CYP2A6 gene is deleted .
16135656	0	nicotine	61,69	CYP2A6	0,6	nicotine	CYP2A6	MESH:D009538	1548	Chemical	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	CYP2A6 AND CYP2B6 are involved in nornicotine formation from nicotine in humans : interindividual differences in these contributions .
16188955	0	nicotine	42,50	CYP2A6	16,22	nicotine	CYP2A6	MESH:D009538	1548	Chemical	Gene	metabolism|compound|START_ENTITY Inactivation|nmod|metabolism Inactivation|nmod|END_ENTITY	Inactivation of CYP2A6 and CYP2A13 during nicotine metabolism .
16402086	0	nicotine	41,49	CYP2A6	0,6	nicotine	CYP2A6	MESH:D009538	1548	Chemical	Gene	dependence|compound|START_ENTITY associated|nmod|dependence associated|nsubjpass|polymorphisms polymorphisms|compound|END_ENTITY	CYP2A6 polymorphisms are associated with nicotine dependence and influence withdrawal symptoms in smoking cessation .
16758265	0	nicotine	61,69	CYP2A6	30,36	nicotine	CYP2A6	MESH:D009538	1548	Chemical	Gene	kinetics|compound|START_ENTITY using|nmod|kinetics END_ENTITY|xcomp|using	Characterization of the novel CYP2A6 * 21 allele using in vivo nicotine kinetics .
17112802	0	nicotine	63,71	CYP2A6	0,6	nicotine	CYP2A6	MESH:D009538	1548	Chemical	Gene	kinetics|nmod|START_ENTITY kinetics|nsubj|genotype genotype|nummod|END_ENTITY	CYP2A6 genotype and the metabolism and disposition kinetics of nicotine .
17130279	0	nicotine	39,47	CYP2A6	12,18	nicotine	CYP2A6	MESH:D009538	1548	Chemical	Gene	dependence|compound|START_ENTITY emergence|nmod|dependence role|nmod|emergence role|nmod|END_ENTITY	The role of CYP2A6 in the emergence of nicotine dependence in adolescents .
17522595	0	nicotine	99,107	CYP2A6	24,30	nicotine	CYP2A6	MESH:D009538	1548	Chemical	Gene	metabolism|compound|START_ENTITY faster|nmod|metabolism associated|nmod|faster Identification|parataxis|associated Identification|nmod|END_ENTITY	Identification of novel CYP2A6 * 1B variants : the CYP2A6 * 1B allele is associated with faster in vivo nicotine metabolism .
17522595	0	nicotine	99,107	CYP2A6	48,54	nicotine	CYP2A6	MESH:D009538	1548	Chemical	Gene	metabolism|compound|START_ENTITY faster|nmod|metabolism associated|nmod|faster associated|nsubjpass|allele allele|compound|END_ENTITY	Identification of novel CYP2A6 * 1B variants : the CYP2A6 * 1B allele is associated with faster in vivo nicotine metabolism .
18065502	0	nicotine	65,73	CYP2A6	47,53	nicotine	CYP2A6	MESH:D009538	1548	Chemical	Gene	metabolism|compound|START_ENTITY inhibiting|dobj|metabolism END_ENTITY|acl|inhibiting	Selegiline is a mechanism-based inactivator of CYP2A6 inhibiting nicotine metabolism in humans and mice .
19090569	0	nicotine	71,79	CYP2A6	93,99	nicotine	CYP2A6	MESH:D009538	1548	Chemical	Gene	enzyme|compound|START_ENTITY enzyme|compound|END_ENTITY	Conceptual DFT properties-based 3D QSAR : analysis of inhibitors of the nicotine metabolizing CYP2A6 enzyme .
21443033	0	nicotine	65,73	CYP2A6	21,27	nicotine	CYP2A6	MESH:D009538	1548	Chemical	Gene	metabolism|compound|START_ENTITY marker|nmod|metabolism Relationship|nmod|marker Relationship|nmod|polymorphism polymorphism|compound|END_ENTITY	Relationship between CYP2A6 genetic polymorphism , as a marker of nicotine metabolism , and ulcerative_colitis .
21597399	0	nicotine	58,66	CYP2A6	27,33	nicotine	CYP2A6	MESH:D009538	1548	Chemical	Gene	metabolism|compound|START_ENTITY variation|nmod|metabolism alleles|nmod|variation alleles|nsubj|contribution contribution|nmod|END_ENTITY	The contribution of common CYP2A6 alleles to variation in nicotine metabolism among European-Americans .
21655912	0	nicotine	93,101	CYP2A6	83,89	nicotine	CYP2A6	MESH:D009538	1548	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	A LC-MS/MS method for concurrent determination of nicotine metabolites and role of CYP2A6 in nicotine metabolism in U937 macrophages : implications in oxidative stress in HIV + smokers .
21784037	0	nicotine	53,61	CYP2A6	17,23	nicotine	CYP2A6	MESH:D009538	1548	Chemical	Gene	metabolism|compound|START_ENTITY polymorphisms|nmod|metabolism polymorphisms|nsubj|influence influence|nmod|END_ENTITY	The influence of CYP2A6 polymorphisms and cadmium on nicotine metabolism in Thai population .
22498344	0	nicotine	98,106	CYP2A6	88,94	nicotine	CYP2A6	MESH:D009538	1548	Chemical	Gene	oxidative|amod|START_ENTITY END_ENTITY|nmod|oxidative	An LC-MS/MS method for concurrent determination of nicotine metabolites and the role of CYP2A6 in nicotine metabolite-mediated oxidative stress in SVGA astrocytes .
22569203	0	nicotine	61,69	CYP2A6	0,6	nicotine	CYP2A6	MESH:D009538	1548	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	CYP2A6 and CYP2B6 genetic variation and its association with nicotine metabolism in South Western Alaska_Native people .
23371292	0	nicotine	42,50	CYP2A6	104,110	nicotine	CYP2A6	MESH:D009538	1548	Chemical	Gene	exposure|compound|START_ENTITY predict|dobj|exposure ability|acl|predict altered|nsubjpass|ability altered|nmod|differences differences|nmod|END_ENTITY	The ability of plasma cotinine to predict nicotine and carcinogen exposure is altered by differences in CYP2A6 : the influence of genetics , race , and sex .
23462429	0	nicotine	12,20	CYP2A6	0,6	nicotine	CYP2A6	MESH:D009538	1548	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|nummod|END_ENTITY	CYP2A6 slow nicotine metabolism is associated with increased quitting by adolescent smokers .
24033696	0	nicotine	55,63	CYP2A6	81,87	nicotine	CYP2A6	MESH:D009538	1548	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Pharmacotherapy effects on smoking cessation vary with nicotine metabolism gene -LRB- CYP2A6 -RRB- .
27035242	0	nicotine	39,47	CYP2A6	100,106	nicotine	CYP2A6	MESH:D009538	1548	Chemical	Gene	kinetics|nmod|START_ENTITY kinetics|dep|impact impact|nmod|variation variation|nummod|END_ENTITY	Disposition kinetics and metabolism of nicotine and cotinine in African American smokers : impact of CYP2A6 genetic variation and enzymatic activity .
9827545	0	nicotine	52,60	CYP2A6	41,47	nicotine	CYP2A6	MESH:D009538	1548	Chemical	Gene	C-oxidase|nsubj|START_ENTITY C-oxidase|advcl|Genotyping Genotyping|nmod|cytochrome_P450_2A6 cytochrome_P450_2A6|appos|END_ENTITY	Genotyping of human cytochrome_P450_2A6 -LRB- CYP2A6 -RRB- , a nicotine C-oxidase .
10799646	0	nicotine	88,96	CYP2B1	57,63	nicotine	CYP2B1	MESH:D009538	24300(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY END_ENTITY|nmod|treatment	Regional and cellular induction of nicotine-metabolizing CYP2B1 in rat brain by chronic nicotine treatment .
11602665	0	nicotine	13,21	CYP2E1	41,47	nicotine	CYP2E1	MESH:D009538	25086(Tax:10116)	Chemical	Gene	doses|nmod|START_ENTITY induce|nsubj|doses induce|dobj|metabolism metabolism|compound|END_ENTITY	Low doses of nicotine and ethanol induce CYP2E1 and chlorzoxazone metabolism in rat liver .
12711639	0	nicotine	27,35	CYP2E1	6,12	nicotine	CYP2E1	MESH:D009538	25086(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Brain CYP2E1 is induced by nicotine and ethanol in rat and is higher in smokers and alcoholics .
12750430	0	nicotine	42,50	CYP2E1	12,18	nicotine	CYP2E1	MESH:D009538	1571	Chemical	Gene	doses|compound|START_ENTITY induced|nmod|doses induced|nsubjpass|END_ENTITY	Rat hepatic CYP2E1 is induced by very low nicotine doses : an investigation of induction , time course , dose response , and mechanism .
16368115	0	nicotine	90,98	CYP2E1	38,44	nicotine	CYP2E1	MESH:D009538	1571	Chemical	Gene	distribution|nmod|START_ENTITY distribution|nmod|END_ENTITY	Regional and cellular distribution of CYP2E1 in monkey brain and its induction by chronic nicotine .
16434548	0	nicotine	61,69	CYP2E1	48,54	nicotine	CYP2E1	MESH:D009538	25086(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY END_ENTITY|nmod|treatment	Induction and recovery time course of rat brain CYP2E1 after nicotine treatment .
19285975	0	nicotine	113,121	CYP2E1	47,53	nicotine	CYP2E1	MESH:D009538	25086(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY CYP2B1/2|nmod|treatment CYP2B1/2|nsubj|induction induction|nmod|END_ENTITY	Differential induction of ethanol-metabolizing CYP2E1 and nicotine-metabolizing CYP2B1/2 in rat liver by chronic nicotine treatment and voluntary_ethanol_intake .
15727510	0	nicotine	14,22	Chrna4	63,69	nicotine	Chrna4	MESH:D009538	11438(Tax:10090)	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|polymorphism polymorphism|compound|END_ENTITY	Modulation of nicotine but not ethanol preference by the mouse Chrna4 A529T polymorphism .
20061993	0	nicotine	42,50	Chrna4	0,6	nicotine	Chrna4	MESH:D009538	11438(Tax:10090)	Chemical	Gene	sensitivity|compound|START_ENTITY altered|dobj|sensitivity altered|nsubj|exhibit exhibit|nummod|END_ENTITY	Chrna4 A529 knock-in mice exhibit altered nicotine sensitivity .
16084497	0	nicotine	59,67	DARPP-32	0,8	nicotine	DARPP-32	MESH:D009538	19049(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY opposes|dobj|effects opposes|nsubj|phosphorylation phosphorylation|compound|END_ENTITY	DARPP-32 phosphorylation opposes the behavioral effects of nicotine .
25218871	0	nicotine	94,102	DISC1	11,16	nicotine	DISC1	MESH:D009538	27185	Chemical	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	Peripheral DISC1 protein levels as a trait marker for schizophrenia and modulating effects of nicotine .
25218871	9	nicotine	1592,1600	DISC1	1522,1527	nicotine	DISC1	MESH:D009538	27185	Chemical	Gene	exposed|nmod|START_ENTITY individuals|acl|exposed lymphocytes|nmod|individuals levels|nmod|lymphocytes levels|compound|END_ENTITY	Reduced DISC1 protein levels in lymphocytes of healthy individuals exposed to nicotine suggest that peripheral DISC1 could have potential for monitoring the effects of psychoactive substances .
16085504	0	nicotine	55,63	DRD2	19,23	nicotine	DRD2	MESH:D009538	1813	Chemical	Gene	effects|nmod|START_ENTITY receptor|dep|effects receptor|appos|END_ENTITY	Dopamine receptor -LRB- DRD2 -RRB- genotype-dependent effects of nicotine on attention and distraction during rapid visual information processing .
19046379	0	nicotine	63,71	Dendrin	35,42	nicotine	Dendrin	MESH:D009538	25113(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	The dendritically_targeted protein Dendrin is induced by acute nicotine in cortical regions of adolescent rat brain .
19451839	0	nicotine	57,65	Dopamine_transporter	0,20	nicotine	Dopamine transporter	MESH:D009538	6531	Chemical	Gene	therapy|compound|START_ENTITY imaging|nmod|therapy imaging|compound|END_ENTITY	Dopamine_transporter imaging under high-dose transdermal nicotine therapy in Parkinson 's _ disease : an observational study .
10837847	0	nicotine	16,24	Fos	28,31	nicotine	Fos	MESH:D009538	314322(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effect of acute nicotine on Fos protein expression in rat brain during chronic nicotine and its withdrawal .
10837847	0	nicotine	79,87	Fos	28,31	nicotine	Fos	MESH:D009538	314322(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|nicotine nicotine|nmod|expression expression|compound|END_ENTITY	Effect of acute nicotine on Fos protein expression in rat brain during chronic nicotine and its withdrawal .
8728564	0	nicotine	69,77	Fos	14,17	nicotine	Fos	MESH:D009538	314322(Tax:10116)	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|protein protein|compound|END_ENTITY	Expression of Fos protein in various rat brain areas following acute nicotine and diazepam .
9272482	0	nicotine	8,16	Fos	53,56	nicotine	Fos	MESH:D009538	314322(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|preferentially preferentially|compound|END_ENTITY	Chronic nicotine enhances basal and nicotine-induced Fos immunoreactivity preferentially in the medial prefrontal cortex of the rat .
24412683	0	nicotine	84,92	FosB	58,62	nicotine	FosB	MESH:D009538	100360880	Chemical	Gene	administration|compound|START_ENTITY END_ENTITY|nmod|administration	Ethanol conditioned place preference and alterations in FosB following adolescent nicotine administration differ in rats exhibiting high or low behavioral reactivity to a novel environment .
16794563	0	nicotine	14,22	Gpr51	26,31	nicotine	Gpr51	MESH:D009538	83633(Tax:10116)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation by nicotine of Gpr51 and Ntrk2 expression in various rat brain regions .
16499655	0	nicotine	79,87	HSP70	24,29	nicotine	HSP70	MESH:D009538	266759(Tax:10116)	Chemical	Gene	exposed|nmod|START_ENTITY exposed|nsubj|expression expression|nmod|END_ENTITY	Perinatal expression of HSP70 and VEGF in neonatal rat lung vessels exposed to nicotine during gestation .
10453373	0	nicotine	12,20	IL-8	39,43	nicotine	IL-8	MESH:D009538	3576	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|compound|END_ENTITY	Transdermal nicotine decreases mucosal IL-8 expression but has no effect on mucin gene expression in ulcerative_colitis .
19433117	0	nicotine	94,102	MCT1	57,61	nicotine	MCT1	MESH:D009538	25027(Tax:10116)	Chemical	Gene	administration|nmod|START_ENTITY END_ENTITY|nmod|administration	Increased densities of monocarboxylate transport protein MCT1 after chronic administration of nicotine in rat brain .
8974638	0	nicotine	127,135	NPY	111,114	nicotine	NPY	MESH:D009538	24604(Tax:10116)	Chemical	Gene	effects|nmod:poss|START_ENTITY mediate|dobj|effects mediate|nsubj|END_ENTITY	Nicotine administration reduces neuropeptide Y and neuropeptide Y mRNA concentrations in the rat hypothalamus : NPY may mediate nicotine 's effects on energy balance .
21265240	0	nicotine	131,139	OPG	105,108	nicotine	OPG	MESH:D009538	25341(Tax:10116)	Chemical	Gene	treated|nmod|START_ENTITY Effects|acl|treated Effects|nmod|receptor_activator_of_nuclear_factor_kappa_B_ligand receptor_activator_of_nuclear_factor_kappa_B_ligand|appos|END_ENTITY	Effects of vitamin_E on receptor_activator_of_nuclear_factor_kappa_B_ligand -LRB- RANKL -RRB- and osteoprotegerin -LRB- OPG -RRB- in rats treated with nicotine .
15612475	0	nicotine	11,19	Oct-4	23,28	nicotine	Oct-4	MESH:D009538	5460	Chemical	Gene	START_ENTITY|nmod|transcription transcription|compound|END_ENTITY	-LSB- Effect of nicotine on Oct-4 transcription of embryonic stem cells -RSB- .
15749260	0	nicotine	10,18	Oct-4	22,27	nicotine	Oct-4	MESH:D009538	100846986	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effect of nicotine on Oct-4 and Rex-1 expression of mouse embryonic stem cells .
7891117	0	nicotine	109,117	Preproenkephalin	0,16	nicotine	Preproenkephalin	MESH:D009538	18619(Tax:10090)	Chemical	Gene	increased|nmod|START_ENTITY increased|nsubjpass|mRNA mRNA|compound|END_ENTITY	Preproenkephalin mRNA and methionine-enkephalin content are increased in mouse striatum after treatment with nicotine .
21265240	0	nicotine	131,139	RANKL	77,82	nicotine	RANKL	MESH:D009538	117516(Tax:10116)	Chemical	Gene	treated|nmod|START_ENTITY Effects|acl|treated Effects|nmod|receptor_activator_of_nuclear_factor_kappa_B_ligand receptor_activator_of_nuclear_factor_kappa_B_ligand|appos|END_ENTITY	Effects of vitamin_E on receptor_activator_of_nuclear_factor_kappa_B_ligand -LRB- RANKL -RRB- and osteoprotegerin -LRB- OPG -RRB- in rats treated with nicotine .
18448488	0	nicotine	40,48	Stat3	20,25	nicotine	Stat3	MESH:D009538	6774	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Rapid activation of Stat3 and ERK1/2 by nicotine modulates cell proliferation in human bladder_cancer cells .
20106947	0	nicotine	10,18	Stat3	81,86	nicotine	Stat3	MESH:D009538	6774	Chemical	Gene	mediated|nsubjpass|START_ENTITY mediated|nmod|activation activation|nmod|END_ENTITY	Long-term nicotine exposure-induced chemoresistance is mediated by activation of Stat3 and downregulation of ERK1/2 via nAChR and beta-adrenoceptors in human bladder_cancer cells .
11266659	0	nicotine	17,25	THP-1	37,42	nicotine	THP-1	MESH:D009538	2736	Chemical	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	Investigation of nicotine binding to THP-1 cells : evidence for a non-cholinergic binding site .
12575320	0	nicotine	11,19	TNF	40,43	nicotine	TNF	MESH:D009538	7124	Chemical	Gene	START_ENTITY|nmod|secretion secretion|nmod|END_ENTITY	-LSB- Effect of nicotine on the secretion of TNF of human peripheral blood mononuclear cells in vitro -RSB- .
21606497	0	nicotine	54,62	Tristetraprolin	0,15	nicotine	Tristetraprolin	MESH:D009538	7538	Chemical	Gene	effects|nmod|START_ENTITY mediates|dobj|effects mediates|nsubj|END_ENTITY	Tristetraprolin mediates anti-inflammatory effects of nicotine in lipopolysaccharide-stimulated macrophages .
7243622	0	nicotine	23,31	Vasopressin	0,11	nicotine	Vasopressin	MESH:D009538	551	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|END_ENTITY	Vasopressin release by nicotine in the cat .
18164554	0	nicotine	120,128	acetylcholinesterase	37,57	nicotine	acetylcholinesterase	MESH:D009538	11423(Tax:10090)	Chemical	Gene	treatment|compound|START_ENTITY effect|nmod|treatment END_ENTITY|dep|effect	Transgenic_mice overexpressing human acetylcholinesterase and the Swedish amyloid precursor protein mutation : effect of nicotine treatment .
19065315	0	nicotine	10,18	angiotensin-converting_enzyme	47,76	nicotine	angiotensin-converting enzyme	MESH:D009538	1636	Chemical	Gene	Effect|nmod|START_ENTITY metabolites|nsubj|Effect metabolites|nmod|END_ENTITY	Effect of nicotine and nicotine metabolites on angiotensin-converting_enzyme in human endothelial cells .
7403668	0	nicotine	10,18	angiotensin_I_and_II	40,60	nicotine	angiotensin I and II	MESH:D009538	24179(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of nicotine on the metabolism of angiotensin_I_and_II and prostaglandin_E2 in isolated rat lungs .
2412241	0	nicotine	28,36	beta-endorphin	78,92	nicotine	beta-endorphin	MESH:D009538	18976(Tax:10090)	Chemical	Gene	treatment|compound|START_ENTITY effects|nmod|treatment effects|nmod|END_ENTITY	Biphasic effects of chronic nicotine treatment on hypothalamic immunoreactive beta-endorphin in the mouse .
17136517	0	nicotine	77,85	beta2	0,5	nicotine	beta2	MESH:D009538	15130(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY mediate|dobj|effect mediate|nsubj|receptors receptors|amod|END_ENTITY	beta2 subunit-containing nicotinic receptors mediate the enhancing effect of nicotine on trace cued fear conditioning in C57BL/6 mice .
2388527	0	nicotine	36,44	bombesin	24,32	nicotine	bombesin	MESH:D009538	2922	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|END_ENTITY	Modulation of pulmonary bombesin by nicotine and vagotomy .
24685651	0	nicotine	14,22	bone_morphogenetic_protein_2	62,90	nicotine	bone morphogenetic protein 2	MESH:D009538	650	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of nicotine on osteoinduction by recombinant human bone_morphogenetic_protein_2 .
21990022	0	nicotine	15,23	brain-derived_neurotrophic_factor	42,75	nicotine	brain-derived neurotrophic factor	MESH:D009538	24225(Tax:10116)	Chemical	Gene	produces|nsubj|START_ENTITY produces|dobj|END_ENTITY	Gestational IV nicotine produces elevated brain-derived_neurotrophic_factor in the mesocorticolimbic dopamine system of adolescent rat offspring .
22048468	0	nicotine	31,39	c-Fos	84,89	nicotine	c-Fos	MESH:D009538	314322(Tax:10116)	Chemical	Gene	evoked|nmod|START_ENTITY response|acl|evoked induces|nsubj|response induces|dobj|expression expression|amod|END_ENTITY	Conditioned response evoked by nicotine conditioned stimulus preferentially induces c-Fos expression in medial regions of caudate-putamen .
22414858	0	nicotine	9,17	c-Fos	70,75	nicotine	c-Fos	MESH:D009538	314322(Tax:10116)	Chemical	Gene	ispronicline|compound|START_ENTITY induces|nsubj|ispronicline induces|dobj|expression expression|amod|END_ENTITY	The a4b2 nicotine acetylcholine receptor agonist ispronicline induces c-Fos expression in selective regions of the rat forebrain .
25042794	0	nicotine	121,129	c-Fos	34,39	nicotine	c-Fos	MESH:D009538	14281(Tax:10090)	Chemical	Gene	withdrawal|compound|START_ENTITY prevented|nmod|withdrawal prevented|nmod|expressions expressions|amod|END_ENTITY	Baclofen prevented the changes in c-Fos and brain-derived_neutrophic_factor expressions during mecamylamine-precipitated nicotine withdrawal in mice .
10579804	0	nicotine	139,147	c-fos	10,15	nicotine	c-fos	MESH:D009538	314322(Tax:10116)	Chemical	Gene	withdrawal_syndrome|compound|START_ENTITY displaying|dobj|withdrawal_syndrome rats|acl|displaying induction|nmod|rats induction|amod|END_ENTITY	Selective c-fos induction and decreased dopamine release in the central nucleus of amygdala in rats displaying a mecamylamine-precipitated nicotine withdrawal_syndrome .
12558936	0	nicotine	33,41	c-fos	13,18	nicotine	c-fos	MESH:D009538	2353	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Induction of c-fos expression by nicotine in human periodontal ligament fibroblasts is related to cellular thiol levels .
1422856	0	nicotine	88,96	c-fos	13,18	nicotine	c-fos	MESH:D009538	314322(Tax:10116)	Chemical	Gene	administration|nmod|START_ENTITY immunostaining|nmod|administration Induction|acl|immunostaining Induction|nmod|END_ENTITY	Induction of c-fos immunostaining in the rat brain after the systemic administration of nicotine .
17420096	0	nicotine	6,14	c-fos	24,29	nicotine	c-fos	MESH:D009538	314322(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|differentially differentially|amod|END_ENTITY	Acute nicotine enhances c-fos mRNA expression differentially in reward-related substrates of adolescent and adult rat brain .
18848603	0	nicotine	6,14	c-fos	25,30	nicotine	c-fos	MESH:D009538	314322(Tax:10116)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|amod|END_ENTITY	Acute nicotine activates c-fos and activity-regulated_cytoskeletal_associated_protein mRNA expression in limbic brain areas involved in the central stress-response in rat pups during a period of hypo-responsiveness to stress .
8255178	0	nicotine	6,14	c-fos	33,38	nicotine	c-fos	MESH:D009538	314322(Tax:10116)	Chemical	Gene	injections|compound|START_ENTITY induce|nsubj|injections induce|dobj|END_ENTITY	Acute nicotine injections induce c-fos mostly in non-dopaminergic neurons of the midbrain of the rat .
8950089	0	nicotine	30,38	c-fos	84,89	nicotine	c-fos	MESH:D009538	314322(Tax:10116)	Chemical	Gene	properties|nmod|START_ENTITY associated|nsubjpass|properties associated|nmod|patterning patterning|nmod|expression expression|amod|END_ENTITY	The reinforcing properties of nicotine are associated with a specific patterning of c-fos expression in the rat brain .
9098543	0	nicotine	42,50	c-fos	104,109	nicotine	c-fos	MESH:D009538	314322(Tax:10116)	Chemical	Gene	exposure|compound|START_ENTITY caused|nmod|exposure injury|acl|caused associated|nsubjpass|injury associated|nmod|elevations elevations|nmod|expression expression|amod|END_ENTITY	Cryptic brain cell injury caused by fetal nicotine exposure is associated with persistent elevations of c-fos protooncogene expression .
9890606	0	nicotine	30,38	c-fos	11,16	nicotine	c-fos	MESH:D009538	314322(Tax:10116)	Chemical	Gene	induction|nmod|START_ENTITY END_ENTITY|acl|induction	Persistent c-fos induction by nicotine in developing rat brain regions : interaction with hypoxia .
1772432	0	nicotine	76,84	c-myc	29,34	nicotine	c-myc	MESH:D009538	4609	Chemical	Gene	down-regulation|nmod|START_ENTITY down-regulation|nmod|expression expression|amod|END_ENTITY	Transient down-regulation of c-myc protooncogene expression by the alkaloid nicotine in human promyelocytic HL-60 cells .
10622280	0	nicotine	62,70	corticotropin-releasing_factor	14,44	nicotine	corticotropin-releasing factor	MESH:D009538	1392	Chemical	Gene	RNA|nmod|START_ENTITY RNA|nsubj|Regulation Regulation|nmod|messenger messenger|amod|END_ENTITY	Regulation of corticotropin-releasing_factor messenger RNA by nicotine in an immortalized amygdalar cell line .
12941074	0	nicotine	104,112	cyclooxygenase-2	13,29	nicotine	cyclooxygenase-2	MESH:D009538	5743	Chemical	Gene	stimulated|nmod|START_ENTITY stimulated|nsubj|Induction Induction|nmod|mRNA mRNA|amod|END_ENTITY	Induction of cyclooxygenase-2 mRNA and protein expression in human gingival fibroblasts stimulated with nicotine .
15670336	0	nicotine	57,65	cyclooxygenase-2	91,107	nicotine	cyclooxygenase-2	MESH:D009538	29527(Tax:10116)	Chemical	Gene	receptor|nmod|START_ENTITY Activation|nmod|receptor up-regulates|nsubj|Activation up-regulates|xcomp|END_ENTITY	Activation of alpha7 nicotinic acetylcholine receptor by nicotine selectively up-regulates cyclooxygenase-2 and prostaglandin_E2 in rat microglial cultures .
18351285	0	nicotine	106,114	cyclooxygenase-2	32,48	nicotine	cyclooxygenase-2	MESH:D009538	29527(Tax:10116)	Chemical	Gene	areas|nmod|START_ENTITY apoptosis|nmod|areas END_ENTITY|nmod|apoptosis	Immunohistochemical increase in cyclooxygenase-2 without apoptosis in different brain areas of subchronic nicotine - and D-amphetamine-treated rats .
20470258	0	nicotine	26,34	cyclooxygenase-2	81,97	nicotine	cyclooxygenase-2	MESH:D009538	5743	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Heme_oxygenase-1 mediates nicotine - and lipopolysaccharide-induced expression of cyclooxygenase-2 and inducible_nitric_oxide_synthase in human periodontal ligament cells .
11719700	0	nicotine	43,51	cytochrome_P450_2E1	20,39	nicotine	cytochrome P450 2E1	MESH:D009538	1571	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of human cytochrome_P450_2E1 by nicotine , cotinine , and aqueous_cigarette_tar_extract in vitro .
11038246	0	nicotine	84,92	diazepam_binding_inhibitor	49,75	nicotine	diazepam binding inhibitor	MESH:D009538	13167(Tax:10090)	Chemical	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	Mechanism for increase in expression of cerebral diazepam_binding_inhibitor mRNA by nicotine : involvement of L-type voltage-dependent calcium channels .
6158829	0	nicotine	35,43	dopamine-beta-hydroxylase	67,92	nicotine	dopamine-beta-hydroxylase	MESH:D009538	25699(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of chronically administered nicotine on axonal transport of dopamine-beta-hydroxylase in peripheral adrenergic neurons and on blood pressure and heart rate in the rat .
19961902	0	nicotine	11,19	dopamine_D2_receptor	89,109	nicotine	dopamine D2 receptor	MESH:D009538	1813	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|polymorphism polymorphism|amod|END_ENTITY	Effects of nicotine on the amplitude and gating of the auditory P50 and its influence by dopamine_D2_receptor gene polymorphism .
11044890	0	nicotine	33,41	dopamine_transporter	95,115	nicotine	dopamine transporter	MESH:D009538	6531	Chemical	Gene	interactions|nmod|START_ENTITY depend|nsubj|interactions depend|nmod|dose dose|nmod|inhibitor inhibitor|compound|END_ENTITY	Synergistic interactions between nicotine and cocaine or methylphenidate depend on the dose of dopamine_transporter inhibitor .
12135534	0	nicotine	25,33	dopamine_transporter	46,66	nicotine	dopamine transporter	MESH:D009538	6531	Chemical	Gene	action|nmod|START_ENTITY action|nmod|END_ENTITY	Stimulant-like action of nicotine on striatal dopamine_transporter in the brain of adults with attention_deficit_hyperactivity_disorder .
14623374	0	nicotine	143,151	dopamine_transporter	46,66	nicotine	dopamine transporter	MESH:D009538	24898(Tax:10116)	Chemical	Gene	administration|nmod|START_ENTITY chronic|nmod|administration slices|nmod|chronic slices|nsubj|regulation regulation|nmod|END_ENTITY	Nicotinic receptor-mediated regulation of the dopamine_transporter in rat prefrontocortical slices following chronic in vivo administration of nicotine .
14685824	0	nicotine	114,122	dopamine_transporter	40,60	nicotine	dopamine transporter	MESH:D009538	6531	Chemical	Gene	dependence|compound|START_ENTITY risk|nmod|dependence Association|dep|risk Association|nmod|polymorphism polymorphism|nmod|gene gene|compound|END_ENTITY	Association between polymorphism of the dopamine_transporter gene and early smoking onset : an interaction risk on nicotine dependence .
20506223	0	nicotine	58,66	dopamine_transporter	9,29	nicotine	dopamine transporter	MESH:D009538	13162(Tax:10090)	Chemical	Gene	withdrawal|compound|START_ENTITY function|nmod|withdrawal function|nsubj|END_ENTITY	Enhanced dopamine_transporter function in striatum during nicotine withdrawal .
20953833	0	nicotine	18,26	estrogen_receptor	48,65	nicotine	estrogen receptor	MESH:D009538	2099	Chemical	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Crosstalk between nicotine and estrogen-induced estrogen_receptor activation induces a9-nicotinic acetylcholine receptor expression in human breast_cancer cells .
3991359	0	nicotine	10,18	gastrin	76,83	nicotine	gastrin	MESH:D009538	100685087	Chemical	Gene	Effect|nmod|START_ENTITY stimulated|nsubj|Effect stimulated|dobj|levels levels|nmod|polypeptide polypeptide|amod|END_ENTITY	Effect of nicotine on basal_and_bombesin stimulated canine plasma levels of gastrin , cholecystokinin and pancreatic polypeptide .
8952006	0	nicotine	13,21	gastrin	25,32	nicotine	gastrin	MESH:D009538	25320(Tax:10116)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of nicotine on gastrin and peptide_YY in the rat .
8963034	0	nicotine	37,45	gastrin	56,63	nicotine	gastrin	MESH:D009538	25320(Tax:10116)	Chemical	Gene	intake|compound|START_ENTITY influence|nmod|intake influence|nmod|secretion secretion|compound|END_ENTITY	The contrasting influence of chronic nicotine intake on gastrin and gastric_acid secretion .
9178349	0	nicotine	15,23	gastrin	69,76	nicotine	gastrin	MESH:D009538	25320(Tax:10116)	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|expression expression|compound|END_ENTITY	Interaction of nicotine and a H2-receptor antagonist , famotidine , on gastrin and chromogranin_A expression .
16335059	0	nicotine	11,19	glucose_6-phosphate_dehydrogenase	37,70	nicotine	glucose 6-phosphate dehydrogenase	MESH:D009538	24377(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|amod|END_ENTITY	Effects of nicotine and vitamin_E on glucose_6-phosphate_dehydrogenase activity in some rat tissues in vivo and in vitro .
17113070	0	nicotine	11,19	glutathione_reductase	37,58	nicotine	glutathione reductase	MESH:D009538	116686(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|amod|END_ENTITY	Effects of nicotine and vitamin_E on glutathione_reductase activity in some rat tissues in vivo and in vitro .
15131760	0	nicotine	17,25	growth_hormone	51,65	nicotine	growth hormone	MESH:D009538	2688	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nsubj|effects	Acute effects of nicotine on serum glucose insulin growth_hormone and cortisol in healthy smokers .
2073091	0	nicotine	51,59	growth_hormone	69,83	nicotine	growth hormone	MESH:D009538	81668(Tax:10116)	Chemical	Gene	mass|nmod|START_ENTITY regulation|nmod|mass regulation|dep|role role|nmod|END_ENTITY	Endocrine and metabolic regulation of body mass by nicotine : role of growth_hormone .
11422660	8	nicotine	1081,1089	insulin	1105,1112	nicotine	insulin	MESH:D009538	3630	Chemical	Gene	absence|nmod|START_ENTITY END_ENTITY|nmod|absence	In the absence of nicotine , DM2 were more insulin resistant than Ctr -LRB- 6.7 + / - 0.4 vs. 10.9 + / - 0.3 mg kg-1 LBM min -LRB- -1 -RRB- , respectively ; P < 0.0001 -RRB- .
3275854	0	nicotine	19,27	insulin	46,53	nicotine	insulin	MESH:D009538	3630	Chemical	Gene	administration|compound|START_ENTITY Effects|nmod|administration Effects|nmod|END_ENTITY	Effects of chronic nicotine administration on insulin , glucose , epinephrine , and norepinephrine .
4695422	0	nicotine	10,18	insulin	47,54	nicotine	insulin	MESH:D009538	100009181(Tax:9986)	Chemical	Gene	Effect|nmod|START_ENTITY metabolites|nsubj|Effect metabolites|nmod|secretion secretion|compound|END_ENTITY	Effect of nicotine and nicotine metabolites on insulin secretion from rabbit pancreas pieces .
9767362	0	nicotine	12,20	interleukin_2	30,43	nicotine	interleukin 2	MESH:D009538	3558	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|synthesis synthesis|amod|END_ENTITY	Transdermal nicotine inhibits interleukin_2 synthesis by mononuclear cells derived from healthy volunteers .
5885953	0	nicotine	12,20	kallikrein	39,49	nicotine	kallikrein	MESH:D009538	9622	Chemical	Gene	Activity|nmod|START_ENTITY Activity|nmod|END_ENTITY	Activity of nicotine and inactivity of kallikrein and kallidin in aggregation of blood platelets .
15979169	0	nicotine	67,75	kappa-opioid_receptor	4,25	nicotine	kappa-opioid receptor	MESH:D009538	4986	Chemical	Gene	effect|nmod|START_ENTITY involved|nmod|effect involved|nsubjpass|END_ENTITY	The kappa-opioid_receptor is involved in the stimulating effect of nicotine on adrenocortical activity but not in nicotine induced anxiety .
23755407	0	nicotine	20,28	laminin_alpha_5	55,70	nicotine	laminin alpha 5	MESH:D009538	3911	Chemical	Gene	exposure|compound|START_ENTITY Effects|nmod|exposure Effects|nmod|END_ENTITY	Effects of maternal nicotine exposure on expression of laminin_alpha_5 in lung tissue of newborn .
12101081	0	nicotine	81,89	macrophage_inflammatory_protein-1_alpha	33,72	nicotine	macrophage inflammatory protein-1 alpha	MESH:D009538	25542(Tax:10116)	Chemical	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Expression and regulation of the macrophage_inflammatory_protein-1_alpha gene by nicotine in rat alveolar macrophages .
18784291	0	nicotine	103,111	neuregulin_1	21,33	nicotine	neuregulin 1	MESH:D009538	3084	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Presynaptic type III neuregulin_1 is required for sustained enhancement of hippocampal transmission by nicotine and for axonal targeting of alpha7 nicotinic acetylcholine receptors .
1790600	0	nicotine	78,86	ornithine_decarboxylase	21,44	nicotine	ornithine decarboxylase	MESH:D009538	24609(Tax:10116)	Chemical	Gene	regions|nmod|START_ENTITY END_ENTITY|nmod|regions	Acute stimulation of ornithine_decarboxylase in neonatal rat brain regions by nicotine : a central receptor-mediated process ?
1865760	0	nicotine	17,25	ornithine_decarboxylase	111,134	nicotine	ornithine decarboxylase	MESH:D009538	24609(Tax:10116)	Chemical	Gene	exposure|compound|START_ENTITY sensitizes|nsubj|exposure sensitizes|advcl|assessed assessed|nmod|END_ENTITY	Chronic prenatal nicotine exposure sensitizes rat brain to acute postnatal nicotine challenge as assessed with ornithine_decarboxylase .
1865760	0	nicotine	75,83	ornithine_decarboxylase	111,134	nicotine	ornithine decarboxylase	MESH:D009538	24609(Tax:10116)	Chemical	Gene	challenge|compound|START_ENTITY sensitizes|nmod|challenge sensitizes|advcl|assessed assessed|nmod|END_ENTITY	Chronic prenatal nicotine exposure sensitizes rat brain to acute postnatal nicotine challenge as assessed with ornithine_decarboxylase .
4042278	0	nicotine	10,18	ornithine_decarboxylase	69,92	nicotine	ornithine decarboxylase	MESH:D009538	24609(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of nicotine and N ' - nitrosonornicotine on rat lung and trachea ornithine_decarboxylase activity .
19358273	0	nicotine	39,47	osteopontin	13,24	nicotine	osteopontin	MESH:D009538	6696	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Induction of osteopontin expression by nicotine and cigarette smoke in the pancreas and pancreatic_ductal_adenocarcinoma cells .
20579680	0	nicotine	51,59	osteopontin	111,122	nicotine	osteopontin	MESH:D009538	6696	Chemical	Gene	monocyte_chemoattractant_protein-1|nmod|START_ENTITY cells|amod|monocyte_chemoattractant_protein-1 Induction|nmod|cells Induction|dep|role role|nmod|END_ENTITY	Induction of monocyte_chemoattractant_protein-1 by nicotine in pancreatic_ductal_adenocarcinoma cells : role of osteopontin .
20824368	0	nicotine	89,97	osteopontin	15,26	nicotine	osteopontin	MESH:D009538	6696	Chemical	Gene	mediated|nmod|START_ENTITY mediated|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of osteopontin in the matrix-degrading and proangiogenic changes mediated by nicotine in pancreatic_cancer cells .
21781517	0	nicotine	164,172	plasminogen_activator_inhibitor-1	108,141	nicotine	plasminogen activator inhibitor-1	MESH:D009538	5054	Chemical	Gene	induced|nmod|START_ENTITY expression|acl|induced expression|amod|END_ENTITY	-LSB- Interaction of protein_kinase_C-extracellular signal-regulated kinase 1/2 signal pathway in the process of plasminogen_activator_inhibitor-1 expression induced by nicotine in human umbilical vein endothelial cells -RSB- .
2299587	0	nicotine	17,25	prolactin	29,38	nicotine	prolactin	MESH:D009538	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	Acute effects of nicotine on prolactin release in the rat : agonist and antagonist effects of a single injection of nicotine .
25393899	0	nicotine	57,65	resistin	8,16	nicotine	resistin	MESH:D009538	56729	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Role Role|nmod|END_ENTITY	Role of resistin in the inflammatory response induced by nicotine plus lipopolysaccharide in human periodontal ligament cells in vitro .
18778441	0	nicotine	18,26	serotonin_transporter	30,51	nicotine	serotonin transporter	MESH:D009538	25553(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|mRNA mRNA|compound|END_ENTITY	Chronic effect of nicotine on serotonin_transporter mRNA in the raphe nucleus of rats : reversal by co-administration of bupropion .
23199342	0	nicotine	35,43	sirtuin_1	11,20	nicotine	sirtuin 1	MESH:D009538	23411	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Effects of sirtuin_1 activation on nicotine and lipopolysaccharide-induced cytotoxicity and inflammatory cytokine production in human gingival fibroblasts .
20131324	0	nicotine	11,19	surfactant_proteins_A_and_D	33,60	nicotine	surfactant proteins A and D	MESH:D009538	443191(Tax:9940)	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of nicotine on pulmonary surfactant_proteins_A_and_D in ovine lung epithelia .
3350861	0	nicotine	10,18	transferrin	22,33	nicotine	transferrin	MESH:D009538	24825(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|binding binding|compound|END_ENTITY	Effect of nicotine on transferrin binding and iron uptake by cultured rat placenta .
11172479	0	nicotine	5,13	tumor_necrosis_factor-alpha	39,66	nicotine	tumor necrosis factor-alpha	MESH:D009538	24835(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY decreases|nsubj|administration decreases|dobj|expression expression|amod|END_ENTITY	Oral nicotine administration decreases tumor_necrosis_factor-alpha expression in fat tissues in obese rats .
19476543	0	nicotine	42,50	tyrosine_hydroxylase	13,33	nicotine	tyrosine hydroxylase	MESH:D009538	25085(Tax:10116)	Chemical	Gene	mRNA|nmod|START_ENTITY mRNA|amod|END_ENTITY	Induction of tyrosine_hydroxylase mRNA by nicotine in rat midbrain is inhibited by mifepristone .
22245234	0	nicotine	9,17	vascular_endothelial_growth_factor	29,63	nicotine	vascular endothelial growth factor	MESH:D009538	83785(Tax:10116)	Chemical	Gene	effects|compound|START_ENTITY effects|nmod|expression expression|compound|END_ENTITY	Maternal nicotine effects on vascular_endothelial_growth_factor expression and morphometry in rat lungs .
142574	0	nicotine	73,81	vasopressin	28,39	nicotine	vasopressin	MESH:D009538	551	Chemical	Gene	perfusion|compound|START_ENTITY liberation|nmod|perfusion liberation|nmod|END_ENTITY	-LSB- Simultaneous liberation of vasopressin -LRB- ADH -RRB- and of neurophysins during nicotine perfusion in man -RSB- .
8819110	0	nicotine	84,92	vasopressin	34,45	nicotine	vasopressin	MESH:D009538	551	Chemical	Gene	reaction|nmod|START_ENTITY problems|dep|reaction problems|nmod|END_ENTITY	Recent problems with paracervical vasopressin : a possible synergistic reaction with nicotine .
7207642	0	nicotinic	60,69	dopamine_beta-hydroxylase	91,116	nicotinic	dopamine beta-hydroxylase	null	103347199	Chemical	Gene	release|amod|START_ENTITY release|amod|END_ENTITY	The use of the De Deckere-Ten Hoor preparation for study of nicotinic and potassium-evoked dopamine_beta-hydroxylase release from the rabbit heart .
16322787	0	nicotinic_acid	69,83	GPR109A	25,32	nicotinic acid	GPR109A	MESH:D009525	338442	Chemical	Gene	efficacy|nmod|START_ENTITY END_ENTITY|nmod|efficacy	Flushing out the role of GPR109A -LRB- HM74A -RRB- in the clinical efficacy of nicotinic_acid .
17932499	0	nicotinic_acid	33,47	GPR109A	59,66	nicotinic acid	GPR109A	MESH:D009525	338442	Chemical	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Neutrophil apoptosis mediated by nicotinic_acid receptors -LRB- GPR109A -RRB- .
21167710	0	nicotinic_acid	88,102	GPR109A	118,125	nicotinic acid	GPR109A	MESH:D009525	338442	Chemical	Gene	HCA2|amod|START_ENTITY HCA2|appos|END_ENTITY	Structure-activity relationships of trans-substituted-propenoic_acid derivatives on the nicotinic_acid receptor HCA2 -LRB- GPR109A -RRB- .
21768093	0	nicotinic_acid	189,203	GPR109A	213,220	nicotinic acid	GPR109A	MESH:D009525	338442	Chemical	Gene	receptor|amod|START_ENTITY extracellular_signal-regulated_kinases_1_and_2|nmod|receptor END_ENTITY|amod|extracellular_signal-regulated_kinases_1_and_2	Distinct kinetic and spatial patterns of protein kinase C -LRB- PKC -RRB- - and epidermal_growth_factor_receptor -LRB- EGFR -RRB- - dependent activation of extracellular_signal-regulated_kinases_1_and_2 by human nicotinic_acid receptor GPR109A .
22267479	0	nicotinic_acid	29,43	GPR109A	79,86	nicotinic acid	GPR109A	MESH:D009525	338442	Chemical	Gene	effects|nmod|START_ENTITY mediated|nsubjpass|effects mediated|nmod|mechanisms mechanisms|nummod|END_ENTITY	Anti-inflammatory effects of nicotinic_acid in human monocytes are mediated by GPR109A dependent mechanisms .
22743741	0	nicotinic_acid	28,42	GPR109A	16,23	nicotinic acid	GPR109A	MESH:D009525	338442	Chemical	Gene	effects|amod|START_ENTITY Role|nmod|effects Role|appos|END_ENTITY	Role of HCA -LRB- GPR109A -RRB- in nicotinic_acid and fumaric_acid_ester-induced effects on the skin .
6345570	0	nicotinic_acid	117,131	Growth_hormone	0,14	nicotinic acid	Growth hormone	MESH:D009525	2688	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|dep|effects	Growth_hormone , cortisol , and glucagon concentrations during plasma free fatty_acid depression : different effects of nicotinic_acid and an adenosine derivative -LRB- BM_11 .189 -RRB- .
22743741	0	nicotinic_acid	28,42	HCA	8,11	nicotinic acid	HCA	MESH:D009525	266790	Chemical	Gene	effects|amod|START_ENTITY Role|nmod|effects Role|nmod|END_ENTITY	Role of HCA -LRB- GPR109A -RRB- in nicotinic_acid and fumaric_acid_ester-induced effects on the skin .
21768093	0	nicotinic_acid	189,203	extracellular_signal-regulated_kinases_1_and_2	133,179	nicotinic acid	extracellular signal-regulated kinases 1 and 2	MESH:D009525	5594	Chemical	Gene	receptor|amod|START_ENTITY END_ENTITY|nmod|receptor	Distinct kinetic and spatial patterns of protein kinase C -LRB- PKC -RRB- - and epidermal_growth_factor_receptor -LRB- EGFR -RRB- - dependent activation of extracellular_signal-regulated_kinases_1_and_2 by human nicotinic_acid receptor GPR109A .
11085190	0	nicotinic_acid	12,26	growth_hormone	46,60	nicotinic acid	growth hormone	MESH:D009525	2688	Chemical	Gene	analog|amod|START_ENTITY Acipimox|appos|analog stimulates|nsubj|Acipimox stimulates|dobj|secretion secretion|amod|END_ENTITY	Acipimox , a nicotinic_acid analog , stimulates growth_hormone secretion in short healthy prepubertal children .
15511297	0	nicotinic_acid	19,33	insulin	37,44	nicotinic acid	insulin	MESH:D009525	3630	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	Are the effects of nicotinic_acid on insulin resistance precipitated by abnormal phosphorous metabolism ?
17881684	0	nicotinic_acid	42,56	insulin	82,89	nicotinic acid	insulin	MESH:D009525	280829(Tax:9913)	Chemical	Gene	concentration|nmod|START_ENTITY Reduction|nmod|concentration enhances|nsubj|Reduction enhances|nmod|END_ENTITY	Reduction of plasma NEFA concentration by nicotinic_acid enhances the response to insulin in feed-restricted Holstein cows .
3727032	0	nicotinic_acid	15,29	malate_dehydrogenase	33,53	nicotinic acid	malate dehydrogenase	MESH:D009525	4199	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	-LSB- Regulation by nicotinic_acid of malate_dehydrogenase activity in tissues of Black Sea mussels -RSB- .
22500018	0	nicotinic_acid_adenine_dinucleotide_phosphate	29,74	TPC1	152,156	nicotinic acid adenine dinucleotide phosphate	TPC1	MESH:C024376	53373	Chemical	Gene	dependence|amod|START_ENTITY dependence|nmod|END_ENTITY	Membrane potential regulates nicotinic_acid_adenine_dinucleotide_phosphate -LRB- NAADP -RRB- dependence of the pH - and Ca2 + - sensitive organellar two-pore channel TPC1 .
15877999	0	nifedipine	10,20	C-reactive_protein	24,42	nifedipine	C-reactive protein	MESH:D009543	1401	Chemical	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	Effect of nifedipine on C-reactive_protein levels in the coronary sinus and on coronary blood flow in response to acetylcholine in patients with stable angina_pectoris having percutaneous coronary intervention .
6192686	0	nifedipine	41,51	CA2	25,28	nifedipine	CA2	MESH:D009543	54231(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|antagonist antagonist|compound|END_ENTITY	Inhibitory effect of the CA2 + antagonist nifedipine on histamine release from rat peritoneal mast cells .
2663524	0	nifedipine	97,107	Insulin	0,7	nifedipine	Insulin	MESH:D009543	3630	Chemical	Gene	treatment|compound|START_ENTITY secretion|nmod|treatment secretion|amod|END_ENTITY	Insulin secretion and glucose tolerance in non-insulin dependent diabetic patients after chronic nifedipine treatment .
11023675	0	nifedipine	75,85	Keratinocyte_growth_factor	0,26	nifedipine	Keratinocyte growth factor	MESH:D009543	2252	Chemical	Gene	upregulated|nmod|START_ENTITY upregulated|nsubjpass|END_ENTITY	Keratinocyte_growth_factor is upregulated by the hyperplasia-inducing drug nifedipine .
3115895	0	nifedipine	50,60	PLA2	32,36	nifedipine	PLA2	MESH:D009543	18784(Tax:10090)	Chemical	Gene	activity|nmod|START_ENTITY activity|appos|END_ENTITY	Inhibition of phospholipase_A2 -LRB- PLA2 -RRB- activity by nifedipine and nisoldipine is independent of their calcium-channel-blocking activity .
3918237	0	nifedipine	10,20	TRH	24,27	nifedipine	TRH	MESH:D009543	7200	Chemical	Gene	START_ENTITY|nmod|stimulation stimulation|compound|END_ENTITY	Effect of nifedipine on TRH stimulation of TSH and PRL release by the pituitary gland .
17051237	0	nifedipine	10,20	adiponectin	24,35	nifedipine	adiponectin	MESH:D009543	9370	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of nifedipine on adiponectin in hypertensive patients with type_2_diabetes_mellitus .
3005555	0	nifedipine	14,24	alpha-1	28,35	nifedipine	alpha-1	MESH:D009543	146	Chemical	Gene	START_ENTITY|nmod|responses responses|amod|END_ENTITY	Antagonism by nifedipine of alpha-1 and alpha-2 adrenoceptor-mediated responses of human digital arteries .
2873210	0	nifedipine	23,33	angiotensin-II	78,92	nifedipine	angiotensin-II	MESH:D009543	183	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|presence presence|nmod|END_ENTITY	Hemodynamic effects of nifedipine in hypertension in the presence of elevated angiotensin-II and beta-adrenergic blockade .
6756705	0	nifedipine	115,125	angiotensin_II	59,73	nifedipine	angiotensin II	MESH:D009543	183	Chemical	Gene	administration|nmod|START_ENTITY renin|nmod|administration renin|nmod|infusion infusion|nmod|END_ENTITY	Plasma active and inactive renin in man during infusion of angiotensin_II with and without prior administration of nifedipine .
3464943	0	nifedipine	87,97	cytochrome_P-450	70,86	nifedipine	cytochrome P-450	MESH:D009543	4051	Chemical	Gene	oxidase|compound|START_ENTITY oxidase|amod|END_ENTITY	Isolation and sequence determination of a cDNA clone related to human cytochrome_P-450 nifedipine oxidase .
1313765	0	nifedipine	49,59	endothelin-1	10,22	nifedipine	endothelin-1	MESH:D009543	1906	Chemical	Gene	pretreatment|nmod|START_ENTITY Effect|dep|pretreatment Effect|nmod|END_ENTITY	Effect of endothelin-1 in man : pretreatment with nifedipine , with indomethacin and with cyclosporine_A .
17178974	0	nifedipine	35,45	endothelin-1	74,86	nifedipine	endothelin-1	MESH:D009543	1906	Chemical	Gene	treatment|nmod|START_ENTITY reduces|nsubj|treatment reduces|nmod|END_ENTITY	Chronic treatment with long-acting nifedipine reduces vasoconstriction to endothelin-1 in essential hypertension .
8622612	0	nifedipine	224,234	endothelin-1	10,22	nifedipine	endothelin-1	MESH:D009543	1906	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of endothelin-1 in man -- impact on basal and stimulated concentrations of luteinizing hormone , follicle-stimulating hormone , thyrotropin , growth_hormone , corticotropin , and prolactin with and without pretreatment with nifedipine .
9037138	0	nifedipine	85,95	endothelin-1	26,38	nifedipine	endothelin-1	MESH:D009543	24323(Tax:10116)	Chemical	Gene	reversed|nmod|START_ENTITY reversed|nsubjpass|effect effect|nmod|cortex cortex|amod|END_ENTITY	The stimulatory effect of endothelin-1 on regenerating adrenal cortex is reversed by nifedipine .
12533145	0	nifedipine	81,91	endothelin_1	14,26	nifedipine	endothelin 1	MESH:D009543	24323(Tax:10116)	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|Expression Expression|nmod|END_ENTITY	Expression of endothelin_1 in rat random-pattern_skin_flaps treated with topical nifedipine .
1723467	0	nifedipine	11,21	insulin	42,49	nifedipine	insulin	MESH:D009543	3630	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of nifedipine and nitrendipine on insulin secretion in obese patients .
1761067	0	nifedipine	10,20	insulin	58,65	nifedipine	insulin	MESH:D009543	3630	Chemical	Gene	START_ENTITY|nmod|potentiation potentiation|nmod|response response|compound|END_ENTITY	Effect of nifedipine on glucose potentiation of the acute insulin response to arginine in non-insulin-dependent diabetics .
1942746	1	nifedipine	40,50	insulin	65,72	nifedipine	insulin	MESH:D009543	3630	Chemical	Gene	Treatment|nmod|START_ENTITY Treatment|nmod|-RSB- -RSB-|compound|END_ENTITY	Treatment with nifedipine and levels of insulin , glucagon , gastrin and prolactin -RSB- .
7002569	0	nifedipine	42,52	insulin	14,21	nifedipine	insulin	MESH:D009543	3630	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Impairment Impairment|nmod|END_ENTITY	Impairment of insulin secretion in man by nifedipine .
23528007	0	nifedipine	10,20	keratinocyte_growth_factor	42,68	nifedipine	keratinocyte growth factor	MESH:D009543	2252	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	Effect of nifedipine on the expression of keratinocyte_growth_factor and its receptor in cocultured/monocultured fibroblasts and keratinocytes .
7658916	0	nifedipine	14,24	parathyroid_hormone	34,53	nifedipine	parathyroid hormone	MESH:D009543	5741	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of nifedipine on serum parathyroid_hormone and calcitonin in postmenopausal women .
3115895	0	nifedipine	50,60	phospholipase_A2	14,30	nifedipine	phospholipase A2	MESH:D009543	18784(Tax:10090)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Inhibition of phospholipase_A2 -LRB- PLA2 -RRB- activity by nifedipine and nisoldipine is independent of their calcium-channel-blocking activity .
1930858	0	nifedipine	87,97	renin	7,12	nifedipine	renin	MESH:D009543	5972	Chemical	Gene	effects|nmod|START_ENTITY predictors|nmod|effects END_ENTITY|nmod|predictors	Plasma renin activity and norepinephrine as predictors for antihypertensive effects of nifedipine and captopril .
2099358	0	nifedipine	102,112	renin	23,28	nifedipine	renin	MESH:D009543	5972	Chemical	Gene	effect|nmod|START_ENTITY pressure|dep|effect pressure|appos|activity activity|compound|END_ENTITY	Blood pressure , plasma renin activity and calcium metabolism in hypertensive pregnancy : the effect of nifedipine .
2100527	0	nifedipine	81,91	renin	37,42	nifedipine	renin	MESH:D009543	5972	Chemical	Gene	comparison|nmod|START_ENTITY END_ENTITY|dep|comparison	-LSB- Arterial hypertension caused by low renin : comparison of the calcium antagonist nifedipine and the ACE-inhibitor enalapril as to antihypertensive efficacy -RSB- .
2425184	0	nifedipine	11,21	renin	25,30	nifedipine	renin	MESH:D009543	403838(Tax:9615)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|release release|compound|END_ENTITY	Effects of nifedipine on renin release and renal function in anesthetized dogs .
2691077	0	nifedipine	57,67	renin	17,22	nifedipine	renin	MESH:D009543	5972	Chemical	Gene	administration|nmod|START_ENTITY response|nmod|administration response|compound|END_ENTITY	-LSB- Circulatory and renin response to the administration of nifedipine in renovascular_hypertension -RSB- .
2701747	0	nifedipine	11,21	renin	61,66	nifedipine	renin	MESH:D009543	5972	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|compound|END_ENTITY	-LSB- Effect of nifedipine on effective renal plasma flow , plasma renin activity and serum aldosterone , noradrenaline and adrenaline levels in healthy persons and in patients with primary moderate arterial hypertension -RSB- .
398813	0	nifedipine	69,79	renin	19,24	nifedipine	renin	MESH:D009543	5972	Chemical	Gene	-RSB-|amod|START_ENTITY administration|nmod|-RSB- induced|nmod|administration induced|nsubj|Changes Changes|nmod|activity activity|compound|END_ENTITY	-LSB- Changes in plasma renin activity induced by acute administration of nifedipine in hypertensive patients -LRB- author 's transl -RRB- -RSB- .
477707	0	nifedipine	10,20	renin	31,36	nifedipine	renin	MESH:D009543	5972	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of nifedipine on plasma renin , aldosterone and catecholamines in arterial hypertension .
6756705	0	nifedipine	115,125	renin	27,32	nifedipine	renin	MESH:D009543	5972	Chemical	Gene	administration|nmod|START_ENTITY END_ENTITY|nmod|administration	Plasma active and inactive renin in man during infusion of angiotensin_II with and without prior administration of nifedipine .
2433081	0	nifedipine	13,23	vasopressin	59,70	nifedipine	vasopressin	MESH:D009543	551	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of nifedipine and enalapril on osmoregulation of vasopressin .
577165	0	nifenalol	40,49	insulin	53,60	nifenalol	insulin	MESH:C100250	3630	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	-LSB- Influence of the beta-receptor blocker nifenalol on insulin secretion in normal subjects and diabetic patients -LRB- author 's transl -RRB- -RSB- .
21067863	0	niflumic_acid	44,57	Cox-2	28,33	niflumic acid	Cox-2	MESH:D009544	4513	Chemical	Gene	START_ENTITY|nsubj|treatment treatment|nmod|inhibitor inhibitor|compound|END_ENTITY	Combined treatment with the Cox-2 inhibitor niflumic_acid and PPARy ligand ciglitazone induces ER stress/caspase -8 - mediated apoptosis in human lung_cancer cells .
19785662	0	nilotinib	15,24	ABCB1	55,60	nilotinib	ABCB1	MESH:C498826	5243	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of nilotinib , dasatinib and bosutinib with ABCB1 and ABCG2 : implications for altered anti-cancer effects and pharmacological properties .
25721903	0	nilotinib	39,48	ABL	110,113	nilotinib	ABL	MESH:C498826	25	Chemical	Gene	START_ENTITY|nmod|patient patient|nmod|mutation mutation|compound|END_ENTITY	Persistent major molecular response to nilotinib therapy in a patient with chronic_myeloid_leukemia harboring ABL gene T315I mutation .
16721371	0	nilotinib	8,17	BCR-ABL	55,62	nilotinib	BCR-ABL	MESH:C498826	25	Chemical	Gene	AMN107|appos|START_ENTITY AMN107|dep|inhibitor inhibitor|nmod|END_ENTITY	AMN107 -LRB- nilotinib -RRB- : a novel and selective inhibitor of BCR-ABL .
17068153	0	nilotinib	32,41	BCR-ABL	80,87	nilotinib	BCR-ABL	MESH:C498826	25	Chemical	Gene	combining|dobj|START_ENTITY combining|nmod|models models|nmod|_ _|compound|END_ENTITY	Beneficial effects of combining nilotinib and imatinib in preclinical models of BCR-ABL + _ leukemias .
17303698	0	nilotinib	100,109	BCR-ABL	18,25	nilotinib	BCR-ABL	MESH:C498826	25	Chemical	Gene	AMN107|appos|START_ENTITY conferring|nmod|AMN107 conferring|nsubj|Identification Identification|nmod|mutations mutations|amod|END_ENTITY	Identification of BCR-ABL point mutations conferring resistance to the Abl kinase inhibitor AMN107 -LRB- nilotinib -RRB- by a random mutagenesis study .
18338755	0	nilotinib	75,84	BCR-ABL	156,163	nilotinib	BCR-ABL	MESH:C498826	25	Chemical	Gene	variants|nsubj|START_ENTITY variants|nmod|amplification amplification|amod|END_ENTITY	Overcoming imatinib resistance using Src inhibitor CGP76030 , Abl inhibitor nilotinib and Abl/Lyn inhibitor INNO-406 in newly established K562 variants with BCR-ABL gene amplification .
18347292	0	nilotinib	135,144	BCR-ABL	182,189	nilotinib	BCR-ABL	MESH:C498826	25	Chemical	Gene	treated|nmod|START_ENTITY chronic_myeloid_leukemia|acl|treated chronic_myeloid_leukemia|dep|detection detection|nmod|END_ENTITY	Bullous_sweet_syndrome in a patient with t -LRB- 9 ; 22 -RRB- -LRB- q34 ; q11 -RRB- - positive chronic_myeloid_leukemia treated with the tyrosine kinase inhibitor nilotinib : interphase cytogenetic detection of BCR-ABL - positive lesional cells .
18367481	0	nilotinib	168,177	BCR-ABL	46,53	nilotinib	BCR-ABL	MESH:C498826	25	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|monitoring monitoring|nmod|assessment assessment|nmod|activity activity|amod|END_ENTITY	Phospho-CRKL monitoring for the assessment of BCR-ABL activity in imatinib-resistant chronic myeloid_leukemia or Ph + acute_lymphoblastic_leukemia patients treated with nilotinib .
19047160	0	nilotinib	28,37	BCR-ABL	52,59	nilotinib	BCR-ABL	MESH:C498826	25	Chemical	Gene	resistance|nmod|START_ENTITY due|nsubj|resistance due|nmod|END_ENTITY	Evidence that resistance to nilotinib may be due to BCR-ABL , Pgp , or Src kinase overexpression .
20207846	0	nilotinib	83,92	BCR-ABL	30,37	nilotinib	BCR-ABL	MESH:C498826	25	Chemical	Gene	sensitize|nmod|START_ENTITY sensitize|nsubj|RNA RNA|nmod|transcripts transcripts|amod|END_ENTITY	Small interfering RNA against BCR-ABL transcripts sensitize mutated T315I cells to nilotinib .
23065514	0	nilotinib	101,110	BCR-ABL	40,47	nilotinib	BCR-ABL	MESH:C498826	25	Chemical	Gene	treatment|amod|START_ENTITY second-line|dobj|treatment predicts|xcomp|second-line predicts|nsubj|level level|nmod|END_ENTITY	The quantitative level of T315I mutated BCR-ABL predicts for major molecular response to second-line nilotinib or dasatinib treatment in patients with chronic_myeloid_leukemia .
16614241	0	nilotinib	146,155	Bcr-Abl	0,7	nilotinib	Bcr-Abl	MESH:C498826	25	Chemical	Gene	associated|nmod|START_ENTITY predicts|xcomp|associated predicts|nsubj|screening screening|compound|END_ENTITY	Bcr-Abl resistance screening predicts a limited spectrum of point mutations to be associated with clinical resistance to the Abl kinase inhibitor nilotinib -LRB- AMN107 -RRB- .
21762985	0	nilotinib	129,138	Bcr-Abl	10,17	nilotinib	Bcr-Abl	MESH:C498826	25	Chemical	Gene	response|nmod|START_ENTITY patients|acl:relcl|response rare|nmod|patients rare|nsubj|mutations mutations|compound|END_ENTITY	Low-level Bcr-Abl mutations are very rare in chronic myeloid_leukemia patients who are in major molecular response on first-line nilotinib .
25087954	0	nilotinib	24,33	P-Glycoprotein	52,66	nilotinib	P-Glycoprotein	MESH:C498826	5243	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Distinct interaction of nilotinib and imatinib with P-Glycoprotein in intracellular accumulation and cytotoxicity in CML Cell Line K562 cells .
23103446	0	nilotinib	41,50	P-glycoprotein	4,18	nilotinib	P-glycoprotein	MESH:C498826	5243	Chemical	Gene	mediate|advcl|START_ENTITY mediate|nsubj|END_ENTITY	Can P-glycoprotein mediate resistance to nilotinib in human leukaemia cells ?
24786396	0	nilotinib	21,30	c-Abl	4,9	nilotinib	c-Abl	MESH:C498826	25	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	The c-Abl inhibitor , nilotinib , protects dopaminergic neurons in a preclinical animal model of Parkinson 's _ disease .
24091670	0	nilotinib	131,140	stem_cell_factor	160,176	nilotinib	stem cell factor	MESH:C498826	4254	Chemical	Gene	START_ENTITY|nmod|presence presence|nmod|END_ENTITY	PI3K/mTOR pathway inhibitors sensitize chronic_myeloid_leukemia stem cells to nilotinib and restore the response of progenitors to nilotinib in the presence of stem_cell_factor .
2930595	0	nilutamide	22,32	androgen_receptor	40,57	nilutamide	androgen receptor	MESH:C021277	11835(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Inhibitory effects of nilutamide , a new androgen_receptor antagonist , on mouse and human liver cytochrome_P-450 .
2930595	0	nilutamide	22,32	cytochrome_P-450	95,111	nilutamide	cytochrome P-450	MESH:C021277	4051	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Inhibitory effects of nilutamide , a new androgen_receptor antagonist , on mouse and human liver cytochrome_P-450 .
10431478	0	nimesulide	11,21	COX-1	41,46	nimesulide	COX-1	MESH:C012655	4512	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of nimesulide and indometacin on COX-1 and COX-2 : a comparative study .
10721503	0	nimesulide	56,66	COX-2	149,154	nimesulide	COX-2	MESH:C012655	4513	Chemical	Gene	docking|nmod|START_ENTITY docking|nmod|site site|nmod|synthase-2 synthase-2|appos|END_ENTITY	Automated docking and molecular dynamics simulations of nimesulide in the cyclooxygenase active site of human prostaglandin-endoperoxide synthase-2 -LRB- COX-2 -RRB- .
10961716	0	nimesulide	65,75	COX-2	94,99	nimesulide	COX-2	MESH:C012655	26198(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|compound|END_ENTITY	Interaction between NSAIDs and steroid in rat stomach : safety of nimesulide as a preferential COX-2 inhibitor in the stomach .
11171823	0	nimesulide	105,115	COX-2	24,29	nimesulide	COX-2	MESH:C012655	4513	Chemical	Gene	comparison|nmod|START_ENTITY gastrointestinal_injury|dep|comparison associated|nmod|gastrointestinal_injury associated|nsubjpass|inhibition inhibition|nmod|END_ENTITY	Selective inhibition of COX-2 in humans is associated with less gastrointestinal_injury : a comparison of nimesulide and naproxen .
11473974	0	nimesulide	76,86	COX-2	100,105	nimesulide	COX-2	MESH:C012655	26198(Tax:10116)	Chemical	Gene	uterine|nmod|START_ENTITY uterine|parataxis|inhibitor inhibitor|compound|END_ENTITY	Prevention of postoperative_adhesion formation in rat uterine horn model by nimesulide : a selective COX-2 inhibitor .
11673754	6	nimesulide	1324,1334	COX-2	1350,1355	nimesulide	COX-2	MESH:C012655	5743	Chemical	Gene	use|nmod|START_ENTITY symptoms|nmod|use Amelioration|nmod|symptoms indicates|nsubj|Amelioration indicates|ccomp|play play|nsubj|END_ENTITY	Amelioration of the clinical symptoms by use of nimesulide indicates that COX-2 may play an important pathogenetic role in hyperprostaglandin_E_syndrome / antenatal_Bartter_syndrome .
11695069	0	nimesulide	75,85	COX-2	59,64	nimesulide	COX-2	MESH:C012655	4513	Chemical	Gene	START_ENTITY|nsubj|study study|acl|comparing comparing|dobj|efficacy efficacy|nmod|inhibitor inhibitor|compound|END_ENTITY	Double-blind study comparing the long-term efficacy of the COX-2 inhibitor nimesulide and naproxen in patients with osteoarthritis .
11820457	0	nimesulide	38,48	COX-2	13,18	nimesulide	COX-2	MESH:C012655	29527(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|agent agent|compound|END_ENTITY	Effects of a COX-2 preferential agent nimesulide on TNBS-induced acute inflammation in the gut .
12408728	0	nimesulide	62,72	COX-2	133,138	nimesulide	COX-2	MESH:C012655	4513	Chemical	Gene	analogues|nmod|START_ENTITY study|nmod|analogues study|dep|determination determination|nmod|form form|nmod|methanesulfonamides methanesulfonamides|nmod|inhibitors inhibitors|amod|selective selective|amod|END_ENTITY	Spectral and crystallographic study of pyridinic analogues of nimesulide : determination of the active form of methanesulfonamides as COX-2 selective inhibitors .
12499915	0	nimesulide	41,51	COX-2	112,117	nimesulide	COX-2	MESH:C012655	5743	Chemical	Gene	induces|nsubj|START_ENTITY induces|xcomp|independent independent|nmod|END_ENTITY	The selective cyclooxygenase-2 inhibitor nimesulide induces apoptosis in pancreatic_cancer cells independent of COX-2 .
12507282	0	nimesulide	19,29	COX-2	2,7	nimesulide	COX-2	MESH:C012655	26198(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	A COX-2 inhibitor , nimesulide , inhibits chemically-induced rat tongue carcinogenesis through suppression of cell proliferation activity and COX-2 and iNOS expression .
15046380	0	nimesulide	119,129	COX-2	20,25	nimesulide	COX-2	MESH:C012655	4513	Chemical	Gene	comparison|nmod|START_ENTITY Safety|dep|comparison Safety|nmod|inhibitors inhibitors|compound|END_ENTITY	Safety of selective COX-2 inhibitors in aspirin/nonsteroidal anti-inflammatory drug-intolerant patients : comparison of nimesulide , meloxicam , and rofecoxib .
17380299	0	nimesulide	31,41	COX-2	14,19	nimesulide	COX-2	MESH:C012655	4513	Chemical	Gene	effect|amod|START_ENTITY effect|nmod|END_ENTITY	The effect of COX-2 inhibitor , nimesulide , on angiogenetic factors in primary endometrial_carcinoma cell culture .
17485303	2	nimesulide	436,446	COX-2	336,341	nimesulide	COX-2	MESH:C012655	19225(Tax:10090)	Chemical	Gene	COX-2|dep|START_ENTITY inhibitors|nmod|COX-2 using|dobj|inhibitors rat|advcl|using examine|advcl|rat examine|dobj|action action|nmod|END_ENTITY	This study was designed to examine the action of COX-2 in rat ovulation , implantation and decidualization by using two specific inhibitors of COX-2 -LRB- nimesulide and niflumic_acid -RRB- .
17604186	0	nimesulide	26,36	COX-2	53,58	nimesulide	COX-2	MESH:C012655	17709(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Neuroprotective effect of nimesulide , a preferential COX-2 inhibitor , against pentylenetetrazol -LRB- PTZ -RRB- - induced chemical kindling and associated biochemical parameters in mice .
17675820	0	nimesulide	146,156	COX-2	130,135	nimesulide	COX-2	MESH:C012655	26198(Tax:10116)	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Cyclooxygenase _ -LRB- COX -RRB- -2 expression in a rat duodenoesophageal reflux model and chemoprevention of adenocarcinoma by the selective COX-2 inhibitor nimesulide -RSB- .
18481165	0	nimesulide	158,168	COX-2	49,54	nimesulide	COX-2	MESH:C012655	29527(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY increase|dep|effect increase|nmod|expression expression|appos|END_ENTITY	Selective increase of neuronal cyclooxygenase-2 -LRB- COX-2 -RRB- expression in vulnerable brain regions of rats with experimental Wernicke 's _ encephalopathy : effect of nimesulide .
19428334	0	nimesulide	18,28	COX-2	2,7	nimesulide	COX-2	MESH:C012655	5743	Chemical	Gene	analog|compound|START_ENTITY analog|compound|END_ENTITY	A COX-2 inhibitor nimesulide analog selectively induces apoptosis in Her2 overexpressing breast_cancer cells via cytochrome_c dependent mechanisms .
20542113	0	nimesulide	16,26	COX-2	0,5	nimesulide	COX-2	MESH:C012655	5743	Chemical	Gene	analogs|compound|START_ENTITY analogs|compound|END_ENTITY	COX-2 inhibitor nimesulide analogs are aromatase suppressors in breast_cancer cells .
20702753	7	nimesulide	903,913	COX-2	883,888	nimesulide	COX-2	MESH:C012655	19225(Tax:10090)	Chemical	Gene	revealed|nmod|START_ENTITY revealed|dobj|inhibition inhibition|compound|END_ENTITY	Although AEA is hydrolyzed primarily by fatty_acid_amide hydrolase -LRB- FAAH -RRB- , ex vivo autoradiography revealed that COX-2 inhibition by nimesulide redirected -LSB- -LRB- 3 -RRB- H -RSB- AEA substrate from COX-2 to FAAH in the cortex , hippocampus , thalamus , and periaqueductal gray .
21807508	0	nimesulide	64,74	COX-2	48,53	nimesulide	COX-2	MESH:C012655	5743	Chemical	Gene	START_ENTITY|nsubj|Design Design|nmod|probe probe|nmod|inhibitor inhibitor|compound|END_ENTITY	Design and synthesis of a biotinylated probe of COX-2 inhibitor nimesulide analog JCC76 .
24621649	0	nimesulide	11,21	COX-2	35,40	nimesulide	COX-2	MESH:C012655	29527(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Effects of nimesulide , a selective COX-2 inhibitor , on cardiovascular function in 2 rat models of diabetes .
24948067	0	nimesulide	21,31	COX-2	141,146	nimesulide	COX-2	MESH:C012655	26198(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|parataxis|levels levels|compound|END_ENTITY	Protective effect of nimesulide against hepatic_ischemia / reperfusion injury in rats : effects on oxidant/antioxidants , DNA mutation and COX-1 / COX-2 levels .
26455657	0	nimesulide	28,38	COX-2	81,86	nimesulide	COX-2	MESH:C012655	5743	Chemical	Gene	cyclooxygense-2|amod|START_ENTITY cyclooxygense-2|appos|END_ENTITY	Isomeric methoxy analogs of nimesulide for development of brain cyclooxygense-2 -LRB- COX-2 -RRB- - targeted imaging agents : Synthesis , in vitro COX-2-inhibitory potency , and cellular transport properties .
9820127	0	nimesulide	16,26	COX-2	30,35	nimesulide	COX-2	MESH:C012655	4513	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Dual effects of nimesulide , a COX-2 inhibitor , in human platelets .
9925294	0	nimesulide	54,64	COX-2	45,50	nimesulide	COX-2	MESH:C012655	5743	Chemical	Gene	basis|nmod|START_ENTITY basis|nmod|END_ENTITY	Structural basis for selective inhibition of COX-2 by nimesulide .
16552621	0	nimesulide	88,98	Cox-2	72,77	nimesulide	Cox-2	MESH:C012655	17709(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|neuroblastoma neuroblastoma|nmod|mice mice|nmod|low-dose low-dose|nmod|inhibitor inhibitor|compound|END_ENTITY	Inhibition of human neuroblastoma in SCID mice by low-dose of selective Cox-2 inhibitor nimesulide .
16969492	0	nimesulide	28,38	Cyclooxygenase-2	0,16	nimesulide	Cyclooxygenase-2	MESH:C012655	5743	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Cyclooxygenase-2 inhibitor , nimesulide , improves radiation treatment against non-small_cell_lung_cancer both in vitro and in vivo .
16240325	0	nimesulide	14,24	Ets-1	69,74	nimesulide	Ets-1	MESH:C012655	2113	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|amod|END_ENTITY	The effect of nimesulide , a selective cyclooxygenase-2 inhibitor , on Ets-1 and Ets-2 expression in head_and_neck_cancer cell lines .
15203612	0	nimesulide	25,35	cyclo-oxygenase-2	39,56	nimesulide	cyclo-oxygenase-2	MESH:C012655	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Experience of the use of nimesulide , a cyclo-oxygenase-2 selective prostaglandin synthesis inhibitor , in the prevention of preterm_labour in 44 high-risk cases .
19152549	0	nimesulide	11,21	cyclooxygenase-1	73,89	nimesulide	cyclooxygenase-1	MESH:C012655	5742	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|production production|amod|END_ENTITY	Effects of nimesulide , acetylsalicylic_acid , ibuprofen and nabumetone on cyclooxygenase-1 - and cyclooxygenase-2-mediated prostanoid production in healthy volunteers ex vivo .
10369402	0	nimesulide	26,36	cyclooxygenase-2	37,53	nimesulide	cyclooxygenase-2	MESH:C012655	5743	Chemical	Gene	selectivity|amod|START_ENTITY selectivity|amod|END_ENTITY	The in vivo assessment of nimesulide cyclooxygenase-2 selectivity .
10455298	0	nimesulide	66,76	cyclooxygenase-2	39,55	nimesulide	cyclooxygenase-2	MESH:C012655	5743	Chemical	Gene	START_ENTITY|nsubj|properties properties|nmod|inhibitor inhibitor|amod|END_ENTITY	Calcium antagonistic properties of the cyclooxygenase-2 inhibitor nimesulide in human myometrial myocytes .
11011115	0	nimesulide	19,29	cyclooxygenase-2	43,59	nimesulide	cyclooxygenase-2	MESH:C012655	29527(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Chemoprevention by nimesulide , a selective cyclooxygenase-2 inhibitor , of 2-amino-1-methyl-6-phenylimidazo -LSB- 4,5-b -RSB- pyridine -LRB- PhIP -RRB- - induced mammary gland carcinogenesis in rats .
11245450	0	nimesulide	161,171	cyclooxygenase-2	24,40	nimesulide	cyclooxygenase-2	MESH:C012655	29527(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|expression expression|nmod|protein protein|amod|END_ENTITY	Increased expression of cyclooxygenase-2 protein in 4-nitroquinoline-1-oxide-induced rat_tongue_carcinomas and chemopreventive efficacy of a specific inhibitor , nimesulide .
11296546	0	nimesulide	90,100	cyclooxygenase-2	54,70	nimesulide	cyclooxygenase-2	MESH:C012655	5743	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Differential regulation of interleukin-1_beta-induced cyclooxygenase-2 gene expression by nimesulide in human synovial fibroblasts .
11673754	0	nimesulide	149,159	cyclooxygenase-2	21,37	nimesulide	cyclooxygenase-2	MESH:C012655	5743	Chemical	Gene	use|nmod|START_ENTITY antenatal_Bartter_syndrome|dep|use role|dep|antenatal_Bartter_syndrome role|nmod|END_ENTITY	Pathogenetic role of cyclooxygenase-2 in hyperprostaglandin_E_syndrome / antenatal_Bartter_syndrome : therapeutic use of the cyclooxygenase-2 inhibitor nimesulide .
11872629	0	nimesulide	192,202	cyclooxygenase-2	24,40	nimesulide	cyclooxygenase-2	MESH:C012655	29527(Tax:10116)	Chemical	Gene	caused|advmod|START_ENTITY caused|nsubj|expression expression|nmod|protein protein|amod|END_ENTITY	Increased expression of cyclooxygenase-2 protein during rat hepatocarcinogenesis caused by a choline-deficient , L-amino_acid-defined diet and chemopreventive efficacy of a specific inhibitor , nimesulide .
12569549	0	nimesulide	30,40	cyclooxygenase-2	2,18	nimesulide	cyclooxygenase-2	MESH:C012655	101823908	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	A cyclooxygenase-2 inhibitor , nimesulide , inhibits postinitiation phase of N-nitrosobis -LRB- 2-oxopropyl -RRB- amine-induced pancreatic_carcinogenesis in hamsters .
12969784	0	nimesulide	61,71	cyclooxygenase-2	32,48	nimesulide	cyclooxygenase-2	MESH:C012655	29527(Tax:10116)	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|inhibitors inhibitors|amod|END_ENTITY	Inhibitory effects of selective cyclooxygenase-2 inhibitors , nimesulide and etodolac , on the development of squamous_cell_dysplasias_and_carcinomas of the tongue in rats initiated with 4-nitroquinoline_1-oxide .
14977856	0	nimesulide	50,60	cyclooxygenase-2	22,38	nimesulide	cyclooxygenase-2	MESH:C012655	19225(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|inhibitor inhibitor|amod|END_ENTITY	Effect of a selective cyclooxygenase-2 inhibitor , nimesulide , on the growth of lung_tumors and their expression of cyclooxygenase-2_and_peroxisome_proliferator - _ activated_receptor-gamma .
15591708	0	nimesulide	11,21	cyclooxygenase-2	35,51	nimesulide	cyclooxygenase-2	MESH:C012655	29527(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effects of nimesulide , a selective cyclooxygenase-2 inhibitor , on cardiovascular_alterations in endotoxemia .
15615524	0	nimesulide	76,86	cyclooxygenase-2	90,106	nimesulide	cyclooxygenase-2	MESH:C012655	5743	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Design , synthesis , and pharmacological evaluation of pyridinic analogues of nimesulide as cyclooxygenase-2 selective inhibitors .
15731164	0	nimesulide	147,157	cyclooxygenase-2	171,187	nimesulide	cyclooxygenase-2	MESH:C012655	29527(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Inhibition of prostate carcinogenesis in probasin/SV40 T antigen transgenic rats by raloxifene , an antiestrogen with anti-androgen action , but not nimesulide , a selective cyclooxygenase-2 inhibitor .
16225966	0	nimesulide	66,76	cyclooxygenase-2	16,32	nimesulide	cyclooxygenase-2	MESH:C012655	5743	Chemical	Gene	analogue|nmod|START_ENTITY inhibitor|appos|analogue inhibitor|amod|END_ENTITY	A new potential cyclooxygenase-2 inhibitor , pyridinic analogue of nimesulide .
16240325	0	nimesulide	14,24	cyclooxygenase-2	38,54	nimesulide	cyclooxygenase-2	MESH:C012655	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	The effect of nimesulide , a selective cyclooxygenase-2 inhibitor , on Ets-1 and Ets-2 expression in head_and_neck_cancer cell lines .
16273249	0	nimesulide	70,80	cyclooxygenase-2	43,59	nimesulide	cyclooxygenase-2	MESH:C012655	5743	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|cytotoxicity cytotoxicity|nmod|cisplatin cisplatin|nmod|inhibitor inhibitor|amod|END_ENTITY	Inhibition of cytotoxicity of cisplatin by cyclooxygenase-2 inhibitor nimesulide in head_and_neck_cancer cell lines .
17146966	0	nimesulide	25,35	cyclooxygenase-2	39,55	nimesulide	cyclooxygenase-2	MESH:C012655	100009248(Tax:9986)	Chemical	Gene	effects|nmod|START_ENTITY Anti-ischemic|dobj|effects induced|advcl|Anti-ischemic induced|nsubj|inhibitor inhibitor|amod|END_ENTITY	Anti-ischemic effects of nimesulide , a cyclooxygenase-2 inhibitor on the ischemic model of rabbit induced by isoproterenol .
17382448	0	nimesulide	106,116	cyclooxygenase-2	133,149	nimesulide	cyclooxygenase-2	MESH:C012655	19225(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|inhibitor inhibitor|amod|END_ENTITY	Localization of cyclooxygenase-2 in mice vas deferens and its effects on fertility upon suppression using nimesulide : a preferential cyclooxygenase-2 inhibitor .
17382448	0	nimesulide	106,116	cyclooxygenase-2	16,32	nimesulide	cyclooxygenase-2	MESH:C012655	19225(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Localization Localization|nmod|deferens deferens|amod|END_ENTITY	Localization of cyclooxygenase-2 in mice vas deferens and its effects on fertility upon suppression using nimesulide : a preferential cyclooxygenase-2 inhibitor .
17624748	0	nimesulide	125,135	cyclooxygenase-2	152,168	nimesulide	cyclooxygenase-2	MESH:C012655	19225(Tax:10090)	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Localization of cyclooxygenase-2 in mice testis and assessment of its possible role through suppressing its expression using nimesulide : a preferential cyclooxygenase-2 inhibitor .
17624748	0	nimesulide	125,135	cyclooxygenase-2	16,32	nimesulide	cyclooxygenase-2	MESH:C012655	19225(Tax:10090)	Chemical	Gene	using|dobj|START_ENTITY suppressing|advcl|using Localization|acl|suppressing Localization|nmod|testis testis|amod|END_ENTITY	Localization of cyclooxygenase-2 in mice testis and assessment of its possible role through suppressing its expression using nimesulide : a preferential cyclooxygenase-2 inhibitor .
18256803	0	nimesulide	11,21	cyclooxygenase-2	25,41	nimesulide	cyclooxygenase-2	MESH:C012655	19225(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effects of nimesulide , a cyclooxygenase-2 selective inhibitor , on colitis induced tumors .
18481165	0	nimesulide	158,168	cyclooxygenase-2	31,47	nimesulide	cyclooxygenase-2	MESH:C012655	29527(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY increase|dep|effect increase|nmod|expression expression|amod|END_ENTITY	Selective increase of neuronal cyclooxygenase-2 -LRB- COX-2 -RRB- expression in vulnerable brain regions of rats with experimental Wernicke 's _ encephalopathy : effect of nimesulide .
18488158	0	nimesulide	51,61	cyclooxygenase-2	23,39	nimesulide	cyclooxygenase-2	MESH:C012655	19225(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Effects of a selective cyclooxygenase-2 inhibitor , nimesulide , on the growth of ovarian_carcinoma in vivo .
19099228	0	nimesulide	28,38	cyclooxygenase-2	42,58	nimesulide	cyclooxygenase-2	MESH:C012655	29527(Tax:10116)	Chemical	Gene	administration|nmod|START_ENTITY administration|appos|inhibitor inhibitor|amod|END_ENTITY	Four-week administration of nimesulide , a cyclooxygenase-2 inhibitor , improves endothelial_dysfunction in the hindlimb vasculature of streptozotocin-induced diabetic rats .
20214021	0	nimesulide	86,96	cyclooxygenase-2	40,56	nimesulide	cyclooxygenase-2	MESH:C012655	19225(Tax:10090)	Chemical	Gene	decreases|amod|START_ENTITY mice|nmod|decreases epididymis|nmod|mice END_ENTITY|nmod|epididymis	Suppression of constitutively expressed cyclooxygenase-2 in the epididymis of mice by nimesulide decreases sperm motility .
21232215	0	nimesulide	39,49	cyclooxygenase-2	11,27	nimesulide	cyclooxygenase-2	MESH:C012655	5743	Chemical	Gene	combined|advmod|START_ENTITY combined|nsubj|Effect Effect|nmod|inhibitor inhibitor|amod|END_ENTITY	-LSB- Effect of cyclooxygenase-2 inhibitor , nimesulide , combined with cisplatin on lung_cancer -RSB- .
21458568	0	nimesulide	61,71	cyclooxygenase-2	34,50	nimesulide	cyclooxygenase-2	MESH:C012655	5743	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|inhibitor inhibitor|amod|END_ENTITY	In vitro and in vivo effects of a cyclooxygenase-2 inhibitor nimesulide analog JCC76 in aromatase inhibitors-insensitive breast_cancer cells .
9014217	0	nimesulide	11,21	cyclooxygenase-2	38,54	nimesulide	cyclooxygenase-2	MESH:C012655	29527(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effects of nimesulide , a preferential cyclooxygenase-2 inhibitor , on carrageenan-induced pleurisy and stress-induced gastric_lesions in rats .
9253957	0	nimesulide	76,86	cyclooxygenase-2	20,36	nimesulide	cyclooxygenase-2	MESH:C012655	29527(Tax:10116)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activity activity|amod|END_ENTITY	Inhibition of brain cyclooxygenase-2 activity and the antipyretic action of nimesulide .
9427063	0	nimesulide	90,100	cyclooxygenase-2	59,75	nimesulide	cyclooxygenase-2	MESH:C012655	5743	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	In vitro and in vivo pharmacological evidence of selective cyclooxygenase-2 inhibition by nimesulide : an overview .
9473726	0	nimesulide	47,57	cyclooxygenase-2	71,87	nimesulide	cyclooxygenase-2	MESH:C012655	19225(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Suppression of intestinal polyp development by nimesulide , a selective cyclooxygenase-2 inhibitor , in Min mice .
9679967	0	nimesulide	27,37	cyclooxygenase-2	51,67	nimesulide	cyclooxygenase-2	MESH:C012655	29527(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Chemopreventive effects of nimesulide , a selective cyclooxygenase-2 inhibitor , on the development of rat urinary_bladder_carcinomas initiated by N-butyl-N - -LRB- 4-hydroxybutyl -RRB- nitrosamine .
9718267	0	nimesulide	52,62	cyclooxygenase-2	25,41	nimesulide	cyclooxygenase-2	MESH:C012655	29527(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Effects of the selective cyclooxygenase-2 inhibitor nimesulide on vascular contractions in endothelium-denuded rat aorta .
9808683	0	nimesulide	41,51	cyclooxygenase-2	10,26	nimesulide	cyclooxygenase-2	MESH:C012655	5743	Chemical	Gene	Selective|nmod|START_ENTITY Selective|dobj|inhibition inhibition|amod|END_ENTITY	Selective cyclooxygenase-2 inhibition by nimesulide in man .
9855006	0	nimesulide	23,33	cyclooxygenase-2	60,76	nimesulide	cyclooxygenase-2	MESH:C012655	19225(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|inhibitor inhibitor|nmod|END_ENTITY	Suppressive effects of nimesulide , a selective inhibitor of cyclooxygenase-2 , on azoxymethane-induced colon_carcinogenesis in mice .
8601574	0	nimesulide	72,82	cyclooxygenase_2	109,125	nimesulide	cyclooxygenase 2	MESH:C012655	29527(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Suppression of azoxymethane-induced aberrant_crypt_foci in rat colon by nimesulide , a selective inhibitor of cyclooxygenase_2 .
9920026	0	nimesulide	124,134	cyclooxygenase_2	151,167	nimesulide	cyclooxygenase 2	MESH:C012655	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Enhancement of phosphorylation and transcriptional activity of the glucocorticoid_receptor in human synovial fibroblasts by nimesulide , a preferential cyclooxygenase_2 inhibitor .
10342040	0	nimesulide	11,21	interleukin-6	47,60	nimesulide	interleukin-6	MESH:C012655	3569	Chemical	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Effects of nimesulide and sodium_diclofenac on interleukin-6 , interleukin-8 , proteoglycans and prostaglandin_E2 production by human articular chondrocytes in vitro .
2117260	0	nimodipine	10,20	CO2	52,55	nimodipine	CO2	MESH:D009553	717	Chemical	Gene	START_ENTITY|nmod|response response|nmod|END_ENTITY	Effect of nimodipine on cerebrovascular response to CO2 in asymptomatic individuals and patients with subarachnoid_hemorrhage : a transcranial Doppler ultrasound study .
7885173	0	nimodipine	11,21	CO2	53,56	nimodipine	CO2	MESH:D009553	717	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|release release|compound|END_ENTITY	Effects of nimodipine and dexamethasone on low-level CO2 laser-induced release of 51chromium from canine 2C5 gliosarcoma cells .
15713280	0	nimodipine	31,41	Ca2	15,18	nimodipine	Ca2	MESH:D009553	54231(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|antagonist antagonist|amod|END_ENTITY	Effects of the Ca2 + antagonist nimodipine on functional deficits in the peripheral and central nervous system of streptozotocin-diabetic rats .
8019766	0	nimodipine	42,52	Ca2	25,28	nimodipine	Ca2	MESH:D009553	54231(Tax:10116)	Chemical	Gene	antagonist|dep|START_ENTITY antagonist|nsubj|effect effect|nmod|+ +|amod|END_ENTITY	Beneficial effect of the Ca2 + antagonist , nimodipine , on existing diabetic_neuropathy in the BB/Wor rat .
1380937	0	nimodipine	35,45	Calcitonin	0,10	nimodipine	Calcitonin	MESH:D009553	24241(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY enhances|dobj|effects enhances|nsubj|END_ENTITY	Calcitonin enhances the effects of nimodipine on biogenic amines of rat brain .
12956939	0	nimodipine	39,49	P-glycoprotein	0,14	nimodipine	P-glycoprotein	MESH:D009553	287115(Tax:10116)	Chemical	Gene	transport|nmod|START_ENTITY transport|amod|END_ENTITY	P-glycoprotein restricted transport of nimodipine across blood-brain barrier .
1325610	0	nimodipine	90,100	endothelin-1	54,66	nimodipine	endothelin-1	MESH:D009553	24323(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY Cerebral_hypermetabolism|dep|inhibition Cerebral_hypermetabolism|acl|produced produced|nmod|END_ENTITY	Cerebral_hypermetabolism produced by intraventricular endothelin-1 in rats : inhibition by nimodipine .
9849837	0	nimodipine	66,76	endothelin-1	10,22	nimodipine	endothelin-1	MESH:D009553	1906	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of endothelin-1 on spontaneous contractions and effects of nimodipine and isradipine on endothelin-1-induced contractions in myometrial strips isolated from normal pregnant and preeclamptic women .
21134748	0	nipecotic_acid	117,131	GAT-1	135,140	nipecotic acid	GAT-1	MESH:C030278	6529	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Stereospecific synthesis and structure-activity relationships of unsymmetrical 4,4-diphenylbut-3-enyl derivatives of nipecotic_acid as GAT-1 inhibitors .
10684841	0	nipradilol	19,29	a_beta	31,37	nipradilol	a beta	MESH:C036089	351	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of topical nipradilol , a_beta blocking agent with alpha blocking and nitroglycerin-like activities , on intraocular pressure and aqueous dynamics in humans .
25685067	0	niraparib	35,44	PARP	19,23	niraparib	PARP	null	142	Chemical	Gene	Treatment|appos|START_ENTITY Treatment|nmod|inhibitor inhibitor|compound|END_ENTITY	Treatment with the PARP inhibitor , niraparib , sensitizes colorectal_cancer cell lines to irinotecan regardless of MSI/MSS status .
1282466	0	nisoldipine	59,70	Ca2	37,40	nisoldipine	Ca2	MESH:D015737	54231(Tax:10116)	Chemical	Gene	blocker|appos|START_ENTITY blocker|amod|END_ENTITY	The long-term inhibitory effect of a Ca2 + channel blocker , nisoldipine , on cytosolic Ca2 + and contraction in vascular smooth muscle .
1282466	0	nisoldipine	59,70	Ca2	85,88	nisoldipine	Ca2	MESH:D015737	54231(Tax:10116)	Chemical	Gene	blocker|appos|START_ENTITY effect|nmod|blocker effect|nmod|+ +|amod|END_ENTITY	The long-term inhibitory effect of a Ca2 + channel blocker , nisoldipine , on cytosolic Ca2 + and contraction in vascular smooth muscle .
7521477	0	nisoldipine	11,22	endothelin-1	26,38	nisoldipine	endothelin-1	MESH:D015737	24323(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effects of nisoldipine on endothelin-1 - and angiotensin_II-induced immediate/early gene expression and protein synthesis in adult rat ventricular cardiomyocytes .
7528845	0	nisoldipine	10,21	endothelin-1	48,60	nisoldipine	endothelin-1	MESH:D015737	1906	Chemical	Gene	Effect|nmod|START_ENTITY evoked|nsubj|Effect evoked|advcl|END_ENTITY	Effect of nisoldipine on contractions evoked by endothelin-1 in human isolated distal and proximal coronary arteries and veins .
8742913	0	nisoldipine	112,123	endothelin-1	7,19	nisoldipine	endothelin-1	MESH:D015737	1906	Chemical	Gene	administration|amod|START_ENTITY test|nmod|administration test|nsubj|concentrations concentrations|amod|END_ENTITY	Plasma endothelin-1 concentrations in patients with coronary_artery_disease during stress test before and after nisoldipine administration .
2071252	0	nisoldipine	85,96	fibrinogen	67,77	nisoldipine	fibrinogen	MESH:D015737	2244	Chemical	Gene	therapy|amod|START_ENTITY END_ENTITY|nmod|therapy	Improvement of silent myocardial_ischaemia and reduction of plasma fibrinogen during nisoldipine therapy in occult coronary arterial disease .
15306127	0	nisoxetine	57,67	prodynorphin	71,83	nisoxetine	prodynorphin	MESH:C011386	29190(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effects of the selective norepinephrine uptake inhibitor nisoxetine on prodynorphin gene expression in rat CNS .
11161631	0	nitecapone	137,147	COMT	151,155	nitecapone	COMT	MESH:C057364	24267(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Pain behavior and response properties of spinal dorsal horn neurons following experimental diabetic_neuropathy in the rat : modulation by nitecapone , a COMT inhibitor with antioxidant properties .
1734304	0	nitecapone	92,102	COMT	71,75	nitecapone	COMT	MESH:C057364	1312	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	-LSB- 18F -RSB- -6 - fluorodopa PET scanning in Parkinson 's _ disease after selective COMT inhibition with nitecapone -LRB- OR-462 -RRB- .
1888633	0	nitecapone	21,31	COMT	0,4	nitecapone	COMT	MESH:C057364	1312	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	COMT inhibition with nitecapone does not affect the tyramine pressor response .
8491246	0	nitecapone	34,44	COMT	19,23	nitecapone	COMT	MESH:C057364	1312	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|inhibitor inhibitor|amod|END_ENTITY	The effects of the COMT inhibitor nitecapone for one week on exercise haemodynamics and catecholamine disposition .
2043724	0	nitecapone	59,69	catechol-O-methyltransferase	19,47	nitecapone	catechol-O-methyltransferase	MESH:C057364	1312	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Determination of a catechol-O-methyltransferase inhibitor , nitecapone , in human plasma and urine by liquid chromatography .
2225697	0	nitecapone	102,112	catechol-O-methyltransferase	57,85	nitecapone	catechol-O-methyltransferase	MESH:C057364	1312	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Exercise hemodynamics and catecholamine metabolism after catechol-O-methyltransferase inhibition with nitecapone .
2272023	0	nitecapone	58,68	catechol-O-methyltransferase	18,46	nitecapone	catechol-O-methyltransferase	MESH:C057364	1312	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Effect of a novel catechol-O-methyltransferase inhibitor , nitecapone , on the metabolism of L-dopa in healthy volunteers .
8097704	0	nitecapone	82,92	catechol-O-methyltransferase	43,71	nitecapone	catechol-O-methyltransferase	MESH:C057364	24267(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Identification Identification|nmod|metabolites metabolites|nmod|inhibitor inhibitor|amod|END_ENTITY	Identification of major metabolites of the catechol-O-methyltransferase inhibitor nitecapone in the rat and dog .
8001593	0	nitecapone	83,93	catechol_O-methyltransferase	42,70	nitecapone	catechol O-methyltransferase	MESH:C057364	24267(Tax:10116)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Metabolite profiles of two -LSB- 14C -RSB- - labelled catechol_O-methyltransferase inhibitors , nitecapone and entacapone , in rat and mouse urine and rat bile .
22203730	0	nitidine_chloride	41,58	STAT3	14,19	nitidine chloride	STAT3	MESH:C013615	6774	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Inhibition of STAT3 signaling pathway by nitidine_chloride suppressed the angiogenesis and growth of human gastric_cancer .
23847199	0	nitrate	88,95	AFB3	76,80	nitrate	AFB3	CHEBI:48107	837838(Tax:3702)	Chemical	Gene	response|amod|START_ENTITY END_ENTITY|nmod|response	Systems approaches map regulatory networks downstream of the auxin receptor AFB3 in the nitrate response of Arabidopsis_thaliana roots .
17220910	0	nitrate	10,17	ALDH-2	108,114	nitrate	ALDH-2	CHEBI:48107	11669(Tax:10090)	Chemical	Gene	groups|amod|START_ENTITY Number|nmod|groups determines|nsubj|Number determines|dobj|reactivity reactivity|nmod|nitrates nitrates|dep|proof proof|nmod|study study|nmod|END_ENTITY	Number of nitrate groups determines reactivity and potency of organic nitrates : a proof of concept study in ALDH-2 - / - mice .
10330471	0	nitrate	24,31	CHL1	0,4	nitrate	CHL1	CHEBI:48107	837763(Tax:3702)	Chemical	Gene	transporter|compound|START_ENTITY transporter|nsubj|END_ENTITY	CHL1 is a dual-affinity nitrate transporter of Arabidopsis involved in multiple phases of nitrate uptake .
10330471	0	nitrate	90,97	CHL1	0,4	nitrate	CHL1	CHEBI:48107	837763(Tax:3702)	Chemical	Gene	uptake|amod|START_ENTITY phases|nmod|uptake involved|nmod|phases Arabidopsis|acl|involved transporter|nmod|Arabidopsis transporter|nsubj|END_ENTITY	CHL1 is a dual-affinity nitrate transporter of Arabidopsis involved in multiple phases of nitrate uptake .
11487691	0	nitrate	30,37	CHL1	65,69	nitrate	CHL1	CHEBI:48107	837763(Tax:3702)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The Arabidopsis dual-affinity nitrate transporter gene AtNRT1 .1 -LRB- CHL1 -RRB- is activated and functions in nascent organ development during vegetative and reproductive growth .
11912226	0	nitrate	30,37	CHL1	65,69	nitrate	CHL1	CHEBI:48107	837763(Tax:3702)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The Arabidopsis dual-affinity nitrate transporter gene AtNRT1 .1 -LRB- CHL1 -RRB- is regulated by auxin in both shoots and roots .
12509525	0	nitrate	4,11	CHL1	34,38	nitrate	CHL1	CHEBI:48107	837763(Tax:3702)	Chemical	Gene	transporter|nsubj|START_ENTITY transporter|dobj|functions functions|amod|.1 .1|dep|END_ENTITY	The nitrate transporter AtNRT1 .1 -LRB- CHL1 -RRB- functions in stomatal opening and contributes to drought susceptibility in Arabidopsis .
18563586	7	nitrate	985,992	CHL1	1015,1019	nitrate	CHL1	CHEBI:48107	856099(Tax:4932)	Chemical	Gene	presented|nmod|START_ENTITY study|advcl|presented study|dobj|role role|nmod|Thr101 Thr101|nummod|END_ENTITY	Given that CHL1 presented high affinity by nitrate , we study the role of CHL1 Thr101 in yeast .
19766570	0	nitrate	20,27	CHL1	0,4	nitrate	CHL1	CHEBI:48107	10752	Chemical	Gene	sensor|amod|START_ENTITY functions|nmod|sensor functions|nummod|END_ENTITY	CHL1 functions as a nitrate sensor in plants .
8453665	0	nitrate	79,86	CHL1	31,35	nitrate	CHL1	CHEBI:48107	837763(Tax:3702)	Chemical	Gene	transporter|compound|START_ENTITY encodes|dobj|transporter encodes|nsubj|END_ENTITY	The herbicide sensitivity gene CHL1 of Arabidopsis encodes a nitrate-inducible nitrate transporter .
8989878	0	nitrate	45,52	CHL1	0,4	nitrate	CHL1	CHEBI:48107	837763(Tax:3702)	Chemical	Gene	system|amod|START_ENTITY component|nmod|system encodes|dobj|component encodes|nsubj|END_ENTITY	CHL1 encodes a component of the low-affinity nitrate uptake system in Arabidopsis and shows cell type-specific expression in roots .
9844028	0	nitrate	65,72	CHL1	16,20	nitrate	CHL1	CHEBI:48107	837763(Tax:3702)	Chemical	Gene	uptake|compound|START_ENTITY role|nmod|uptake plays|dobj|role plays|nsubj|protein protein|compound|END_ENTITY	The Arabidopsis CHL1 protein plays a major role in high-affinity nitrate uptake .
1840922	0	nitrate	51,58	CHL3	34,38	nitrate	CHL3	CHEBI:48107	840630(Tax:3702)	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Identification of the Arabidopsis CHL3 gene as the nitrate reductase structural gene NIA2 .
26039467	0	nitrate	20,27	HAR1	6,10	nitrate	HAR1	CHEBI:48107	553859(Tax:34305)	Chemical	Gene	inhibition|amod|START_ENTITY mediates|dobj|inhibition mediates|nsubj|END_ENTITY	Shoot HAR1 mediates nitrate inhibition of nodulation in Lotus_japonicus .
25416287	0	nitrate	65,72	NODULE_INCEPTION	0,16	nitrate	NODULE INCEPTION	CHEBI:48107	553854(Tax:34305)	Chemical	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	NODULE_INCEPTION antagonistically regulates gene expression with nitrate in Lotus_japonicus .
12668777	0	nitrate	80,87	NRT1	14,18	nitrate	NRT1	CHEBI:48107	837763(Tax:3702)	Chemical	Gene	responses|acl|START_ENTITY Regulation|dep|responses Regulation|nmod|families families|compound|END_ENTITY	Regulation of NRT1 and NRT2 gene families of Arabidopsis_thaliana : responses to nitrate provision .
17481610	5	nitrate	610,617	NRT1	501,505	nitrate	NRT2	CHEBI:48107	837327(Tax:3702)	Chemical	Gene	uptake|amod|START_ENTITY involved|nmod|uptake known|xcomp|involved known|nsubjpass|Two Two|nmod|genes genes|nummod|END_ENTITY	Two of the NRT1 genes , CHL1 and AtNRT1 .2 , and two of the NRT2 genes , AtNRT2 .1 and AtNRT2 .2 , are known to be involved in nitrate uptake .
18780802	0	nitrate	35,42	NRT1	28,32	nitrate	NRT1	CHEBI:48107	837763(Tax:3702)	Chemical	Gene	transporter|amod|START_ENTITY transporter|compound|END_ENTITY	Mutation of the Arabidopsis NRT1 .5 nitrate transporter causes defective root-to-shoot nitrate transport .
18780802	0	nitrate	86,93	NRT1	28,32	nitrate	NRT1	CHEBI:48107	837763(Tax:3702)	Chemical	Gene	transport|compound|START_ENTITY causes|dobj|transport causes|nsubj|Mutation Mutation|nmod|transporter transporter|compound|END_ENTITY	Mutation of the Arabidopsis NRT1 .5 nitrate transporter causes defective root-to-shoot nitrate transport .
19050168	0	nitrate	81,88	NRT1	56,60	nitrate	NRT1	CHEBI:48107	837763(Tax:3702)	Chemical	Gene	role|nmod|START_ENTITY reveals|dobj|role reveals|nsubj|Characterization Characterization|nmod|END_ENTITY	Characterization of the Arabidopsis nitrate transporter NRT1 .6 reveals a role of nitrate in early embryo development .
19734434	0	nitrate	117,124	NRT1	36,40	nitrate	NRT1	CHEBI:48107	837763(Tax:3702)	Chemical	Gene	remobilization|nmod|START_ENTITY responsible|nmod|remobilization responsible|nsubj|transporter transporter|dep|.7 .7|compound|END_ENTITY	The Arabidopsis nitrate transporter NRT1 .7 , expressed in phloem , is responsible for source-to-sink remobilization of nitrate .
19734434	0	nitrate	16,23	NRT1	36,40	nitrate	NRT1	CHEBI:48107	837763(Tax:3702)	Chemical	Gene	transporter|compound|START_ENTITY transporter|dep|.7 .7|compound|END_ENTITY	The Arabidopsis nitrate transporter NRT1 .7 , expressed in phloem , is responsible for source-to-sink remobilization of nitrate .
20501909	0	nitrate	56,63	NRT1	36,40	nitrate	NRT1	CHEBI:48107	837763(Tax:3702)	Chemical	Gene	removal|amod|START_ENTITY END_ENTITY|nmod|removal	The Arabidopsis nitrate_transporter NRT1 .8 functions in nitrate removal from the xylem sap and mediates cadmium tolerance .
21571952	0	nitrate	12,19	NRT1	32,36	nitrate	NRT1	CHEBI:48107	837763(Tax:3702)	Chemical	Gene	.9|compound|START_ENTITY .9|compound|END_ENTITY	Arabidopsis nitrate transporter NRT1 .9 is important in phloem nitrate transport .
21571952	0	nitrate	62,69	NRT1	32,36	nitrate	NRT1	CHEBI:48107	837763(Tax:3702)	Chemical	Gene	transport|compound|START_ENTITY important|nmod|transport important|nsubj|.9 .9|compound|END_ENTITY	Arabidopsis nitrate transporter NRT1 .9 is important in phloem nitrate transport .
23214130	0	nitrate	17,24	NRT1	38,42	nitrate	NRT1	CHEBI:48107	837763(Tax:3702)	Chemical	Gene	function|nmod|START_ENTITY transporters|nsubj|function transporters|dobj|END_ENTITY	-LSB- The function of nitrate transporters NRT1 in plants -RSB- .
23731054	0	nitrate	147,154	NRT1	37,41	nitrate	NRT1	CHEBI:48107	837763(Tax:3702)	Chemical	Gene	availability|amod|START_ENTITY heterogeneity|nmod|availability participates|nmod|heterogeneity participates|nsubj|nitrate nitrate|acl|signalling signalling|nmod|END_ENTITY	Auxin-mediated nitrate signalling by NRT1 .1 participates in the adaptive response of Arabidopsis root architecture to the spatial heterogeneity of nitrate availability .
23731054	0	nitrate	15,22	NRT1	37,41	nitrate	NRT1	CHEBI:48107	837763(Tax:3702)	Chemical	Gene	START_ENTITY|acl|signalling signalling|nmod|END_ENTITY	Auxin-mediated nitrate signalling by NRT1 .1 participates in the adaptive response of Arabidopsis root architecture to the spatial heterogeneity of nitrate availability .
24006285	0	nitrate	11,18	NRT1	33,37	nitrate	NRT1	CHEBI:48107	837763(Tax:3702)	Chemical	Gene	transporters|compound|START_ENTITY transporters|appos|.11 .11|compound|END_ENTITY	Two phloem nitrate transporters , NRT1 .11 and NRT1 .12 , are important for redistributing xylem-borne_nitrate to enhance plant growth .
24642706	0	nitrate	91,98	NRT1	84,88	nitrate	NRT1	CHEBI:48107	837763(Tax:3702)	Chemical	Gene	function|compound|START_ENTITY function|compound|END_ENTITY	Nitrate regulation of AFB3_and_NAC4 gene expression in Arabidopsis roots depends on NRT1 .1 nitrate transport function .
12068127	0	nitrate	21,28	NRT2	16,20	nitrate	NRT2	CHEBI:48107	837327(Tax:3702)	Chemical	Gene	START_ENTITY|nsubj|Analysis Analysis|nmod|END_ENTITY	Analysis of the NRT2 nitrate transporter family in Arabidopsis .
15319483	0	nitrate	135,142	NRT2	156,160	nitrate	NRT2	CHEBI:48107	837327(Tax:3702)	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Transcript profiling in the chl1-5 mutant of Arabidopsis reveals a role of the nitrate transporter NRT1 .1 in the regulation of another nitrate transporter , NRT2 .1 .
15319483	0	nitrate	79,86	NRT2	156,160	nitrate	NRT2	CHEBI:48107	837327(Tax:3702)	Chemical	Gene	transporter|amod|START_ENTITY role|nmod|transporter reveals|dobj|role reveals|nmod|regulation regulation|nmod|transporter transporter|appos|END_ENTITY	Transcript profiling in the chl1-5 mutant of Arabidopsis reveals a role of the nitrate transporter NRT1 .1 in the regulation of another nitrate transporter , NRT2 .1 .
22227893	0	nitrate	16,23	NRT2	36,40	nitrate	NRT2	CHEBI:48107	837327(Tax:3702)	Chemical	Gene	.4|compound|START_ENTITY .4|compound|END_ENTITY	The Arabidopsis nitrate transporter NRT2 .4 plays a double role in roots and shoots of nitrogen-starved plants .
25065551	0	nitrate	16,23	NRT2	36,40	nitrate	NRT2	CHEBI:48107	837327(Tax:3702)	Chemical	Gene	.5|compound|START_ENTITY .5|compound|END_ENTITY	The Arabidopsis nitrate transporter NRT2 .5 plays a role in nitrate acquisition and remobilization in nitrogen-starved plants .
25065551	0	nitrate	59,66	NRT2	36,40	nitrate	NRT2	CHEBI:48107	837327(Tax:3702)	Chemical	Gene	acquisition|amod|START_ENTITY role|nmod|acquisition plays|dobj|role plays|nsubj|.5 .5|compound|END_ENTITY	The Arabidopsis nitrate transporter NRT2 .5 plays a role in nitrate acquisition and remobilization in nitrogen-starved plants .
11165253	0	nitrate	66,73	Nrt2	40,44	nitrate	Nrt2	CHEBI:48107	837327(Tax:3702)	Chemical	Gene	uptake|amod|START_ENTITY impaired|nmod|uptake impaired|nsubjpass|mutant mutant|acl|affected affected|nmod|genes genes|amod|END_ENTITY	An arabidopsis T-DNA mutant affected in Nrt2 genes is impaired in nitrate uptake .
23409004	0	nitrate	93,100	PA1006	23,29	nitrate	PA1006	CHEBI:48107	879448(Tax:208964)	Chemical	Gene	utilization|amod|START_ENTITY required|nmod|utilization required|nsubjpass|END_ENTITY	Pseudomonas_aeruginosa PA1006 , which plays a role in molybdenum homeostasis , is required for nitrate utilization , biofilm formation , and virulence .
12716019	0	nitrate	7,14	SOD	37,40	nitrate	SOD	CHEBI:48107	6647	Chemical	Gene	START_ENTITY|dobj|activity activity|compound|END_ENTITY	Raised nitrate concentration and low SOD activity in the CSF of sporadic_ALS patients .
16705668	0	nitrate	118,125	SREBP-2	101,108	nitrate	SREBP-2	CHEBI:48107	300095(Tax:10116)	Chemical	Gene	protein|nmod|START_ENTITY protein|appos|END_ENTITY	Gender-related difference in altered gene expression of a sterol regulatory element binding protein , SREBP-2 , by lead nitrate in rats : correlation with development of hypercholesterolemia .
9020872	0	nitrate	27,34	YNT1	4,8	nitrate	YNT1	CHEBI:48107	852003(Tax:4932)	Chemical	Gene	transporter|amod|START_ENTITY encoding|dobj|transporter gene|acl|encoding gene|compound|END_ENTITY	The YNT1 gene encoding the nitrate transporter in the yeast Hansenula_polymorpha is clustered with genes YNI1 and YNR1 encoding nitrite reductase and nitrate reductase , and its disruption causes inability to grow in nitrate .
9794807	0	nitrate	117,124	YNT1	144,148	nitrate	YNT1	CHEBI:48107	852003(Tax:4932)	Chemical	Gene	genes|amod|START_ENTITY 2Cys6|nmod|genes Clustering|dep|2Cys6 Clustering|nsubj|END_ENTITY	Clustering of the YNA1 gene encoding a Zn -LRB- II -RRB- 2Cys6 transcriptional factor in the yeast Hansenula_polymorpha with the nitrate assimilation genes YNT1 , YNI1 and YNR1 , and its involvement in their transcriptional activation .
14968431	0	nitrate	20,27	Ynt1	12,16	nitrate	Ynt1	CHEBI:48107	852003(Tax:4932)	Chemical	Gene	transport|amod|START_ENTITY END_ENTITY|nmod|transport	The role of Ynt1 in nitrate and nitrite transport in the yeast Hansenula_polymorpha .
18713738	0	nitrate	29,36	Ynt1	49,53	nitrate	Ynt1	CHEBI:48107	852003(Tax:4932)	Chemical	Gene	START_ENTITY|ccomp|essential essential|nsubj|END_ENTITY	Phosphorylation of the yeast nitrate transporter Ynt1 is essential for delivery to the plasma membrane during nitrogen limitation .
1911837	0	nitrate	15,22	anion_exchange_protein	36,58	nitrate	anion exchange protein	CHEBI:48107	6521	Chemical	Gene	The|nmod|START_ENTITY The|nmod|END_ENTITY	The binding of nitrate to the human anion_exchange_protein -LRB- AE1 -RRB- studied with 14N nuclear magnetic resonance .
6237611	0	nitrate	27,34	nit-1	86,91	nitrate	nit-1	CHEBI:48107	429566(Tax:9031)	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	In vitro reconstitution of nitrate reductase activity of the Neurospora_crassa mutant nit-1 : specific incorporation of molybdopterin .
15969098	0	nitrate	42,49	nitrate_reductase	65,82	nitrate	nitrate reductase	CHEBI:48107	100736473	Chemical	Gene	START_ENTITY|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Induced activity of nitrate_reductase by nitrate and cloning of nitrate_reductase gene -RSB- .
1859433	0	nitrate	67,74	phosphoenolpyruvate_carboxylase	14,45	nitrate	phosphoenolpyruvate carboxylase	CHEBI:48107	100101511(Tax:4577)	Chemical	Gene	leaves|nmod|START_ENTITY leaves|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of phosphoenolpyruvate_carboxylase from maize leaves by nitrate and alanine .
16662475	0	nitrate	85,92	reductase	93,102	nitrate	reductase	CHEBI:48107	547911(Tax:3847)	Chemical	Gene	activities|amod|START_ENTITY activities|compound|END_ENTITY	Differential effect of tungsten on the development of endogenous and nitrate-induced nitrate reductase activities in soybean leaves .
16663032	0	nitrate	37,44	reductase	45,54	nitrate	reductase	CHEBI:48107	547911(Tax:3847)	Chemical	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Soybean mutants lacking constitutive nitrate reductase activity : I. Selection and initial plant characterization .
8534848	0	nitrate	61,68	reductase	69,78	nitrate	reductase	CHEBI:48107	547911(Tax:3847)	Chemical	Gene	genes|amod|START_ENTITY genes|compound|END_ENTITY	Identification of cDNA clones corresponding to two inducible nitrate reductase genes in soybean : analysis in wild-type and nr1 mutant .
24520693	0	nitrate	75,82	tank	66,70	nitrate	tank	CHEBI:48107	10010	Chemical	Gene	removal|amod|START_ENTITY END_ENTITY|nmod|removal	Optimization and evaluation of a bottom substrate denitrification tank for nitrate removal from a recirculating aquaculture system .
7943184	0	nitrate	108,115	tumor_necrosis_factor-alpha	42,69	nitrate	tumor necrosis factor-alpha	CHEBI:48107	24835(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY mRNA|acl|induced mRNA|compound|END_ENTITY	Dexamethasone inhibits induction of liver tumor_necrosis_factor-alpha mRNA and liver growth induced by lead nitrate and ethylene_dibromide .
20527992	0	nitrated_tyrosine	90,107	SCOT	120,124	nitrated tyrosine	SCOT	null	64059(Tax:10090)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	The nitrated proteome in heart mitochondria of the db/db mouse model : characterization of nitrated_tyrosine residues in SCOT .
10338458	0	nitrates	73,81	angiotensin-converting_enzyme	134,163	nitrates	angiotensin-converting enzyme	MESH:D009566	1636	Chemical	Gene	effect|nmod|START_ENTITY evaluate|dobj|effect study|acl|evaluate treated|nsubj|study treated|nmod|inhibition inhibition|amod|END_ENTITY	Double-blind , placebo-controlled study to evaluate the effect of organic nitrates in patients with chronic_heart_failure treated with angiotensin-converting_enzyme inhibition .
1756422	0	nitrates	36,44	angiotensin-converting_enzyme	50,79	nitrates	angiotensin-converting enzyme	MESH:D009566	1636	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Vasodilator therapy : interaction of nitrates with angiotensin-converting_enzyme inhibitors .
14523027	0	nitric-oxide	40,52	Endothelin-1	0,12	nitric-oxide	Endothelin-1	MESH:D009569	1906	Chemical	Gene	synthase|amod|START_ENTITY activates|dobj|synthase activates|nsubj|END_ENTITY	Endothelin-1 activates endothelial cell nitric-oxide synthase via heterotrimeric G-protein betagamma subunit signaling to protein jinase B/Akt .
20135642	0	nitric-oxide	66,78	Integrin-linked_kinase	0,22	nitric-oxide	Integrin-linked kinase	MESH:D009569	3611	Chemical	Gene	expression|amod|START_ENTITY involved|nmod|expression involved|nsubjpass|END_ENTITY	Integrin-linked_kinase is involved in TNF-alpha-induced inducible nitric-oxide synthase expression in myoblasts .
11110796	0	nitric-oxide	13,25	NF-kappaB	53,62	nitric-oxide	NF-kappaB	MESH:D009569	18033(Tax:10090)	Chemical	Gene	synthase|amod|START_ENTITY Induction|nmod|synthase Induction|nmod|END_ENTITY	Induction of nitric-oxide synthase and activation of NF-kappaB by interleukin-12 p40 in microglial cells .
12519764	0	nitric-oxide	64,76	heat_shock_protein_90	89,110	nitric-oxide	heat shock protein 90	MESH:D009569	3320	Chemical	Gene	synthase|amod|START_ENTITY synthase|nmod|END_ENTITY	Calmodulin-dependent and - independent activation of endothelial nitric-oxide synthase by heat_shock_protein_90 .
11110796	0	nitric-oxide	13,25	p40	81,84	nitric-oxide	p40	MESH:D009569	16160(Tax:10090)	Chemical	Gene	synthase|amod|START_ENTITY Induction|nmod|synthase Induction|nmod|END_ENTITY	Induction of nitric-oxide synthase and activation of NF-kappaB by interleukin-12 p40 in microglial cells .
11085984	0	nitric-oxide	30,42	tumor_necrosis_factor-alpha	55,82	nitric-oxide	tumor necrosis factor-alpha	MESH:D009569	7124	Chemical	Gene	Activation|nmod|START_ENTITY synthase|nsubj|Activation synthase|nmod|END_ENTITY	Activation of the endothelial nitric-oxide synthase by tumor_necrosis_factor-alpha .
16833878	0	nitric_acid	89,100	TBP	14,17	nitric acid	TBP	MESH:D017942	6908	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of the TBP and water on the complexation of uranyl_nitrate and the dissolution of nitric_acid into supercritical CO2 .
22984626	0	nitric_oxide	55,67	ABO_blood_group	0,15	nitric oxide	ABO blood group	MESH:D009569	28	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	ABO_blood_group is associated with response to inhaled nitric_oxide in neonates with respiratory_failure .
22006996	0	nitric_oxide	104,116	ADAM10	88,94	nitric oxide	ADAM10	MESH:D009569	11487(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY expression|dep|role expression|nmod|END_ENTITY	Hypoxia induces escape from innate immunity in cancer cells via increased expression of ADAM10 : role of nitric_oxide .
21671887	0	nitric_oxide	40,52	AMP-activated_protein_kinase	82,110	nitric oxide	AMP-activated protein kinase	MESH:D009569	78975(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Acute simvastatin increases endothelial nitric_oxide synthase phosphorylation via AMP-activated_protein_kinase and reduces contractility of isolated rat mesenteric resistance arteries .
12770614	0	nitric_oxide	28,40	AP-1	156,160	nitric oxide	AP-1	MESH:D009569	3726	Chemical	Gene	expression|amod|START_ENTITY regulation|nmod|expression regulation|dep|involvement involvement|nmod|END_ENTITY	The regulation of inducible nitric_oxide synthase gene expression induced by lipopolysaccharide and tumor necrosis factor-alpha in C6 cells : involvement of AP-1 and NFkappaB .
15740896	0	nitric_oxide	43,55	AP-1	109,113	nitric oxide	AP-1	MESH:D009569	16476(Tax:10090)	Chemical	Gene	Inhibition|nmod|START_ENTITY synthase|nsubj|Inhibition synthase|advcl|blocking blocking|nmod|activation activation|compound|END_ENTITY	Inhibition of lipopolysaccharide-inducible nitric_oxide synthase expression by acteoside through blocking of AP-1 activation .
16228289	0	nitric_oxide	47,59	AP-1	81,85	nitric oxide	AP-1	MESH:D009569	3726	Chemical	Gene	synthase|amod|START_ENTITY induction|nmod|synthase inhibits|dobj|induction inhibits|advcl|blocking blocking|dobj|activation activation|compound|END_ENTITY	Chrysoeriol potently inhibits the induction of nitric_oxide synthase by blocking AP-1 activation .
8940101	0	nitric_oxide	66,78	AP-1	21,25	nitric oxide	AP-1	MESH:D009569	16476(Tax:10090)	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubj|attenuation attenuation|nmod|factors factors|compound|END_ENTITY	Rapid attenuation of AP-1 transcriptional factors associated with nitric_oxide -LRB- NO -RRB- - mediated neuronal cell death .
9688322	0	nitric_oxide	80,92	AP-1	19,23	nitric oxide	AP-1	MESH:D009569	3726	Chemical	Gene	dependent|amod|START_ENTITY mechanism|amod|dependent cells|nmod|mechanism activity|nmod|cells activity|compound|END_ENTITY	IFN-gamma inhibits AP-1 binding activity in human brain-derived cells through a nitric_oxide dependent mechanism .
16093914	0	nitric_oxide	69,81	AT2	85,88	nitric oxide	AT2	MESH:D009569	20726(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|compound|END_ENTITY	Angiotensin II modulates renal sympathetic neurotransmission through nitric_oxide in AT2 receptor knockout mice .
16683234	0	nitric_oxide	29,41	AUF-1	0,5	nitric oxide	AUF-1	MESH:D009569	3184	Chemical	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	AUF-1 mediates inhibition by nitric_oxide of lipopolysaccharide-induced matrix_metalloproteinase-9 expression in cultured astrocytes .
16092928	0	nitric_oxide	47,59	Adenosine_A2A_receptor	0,22	nitric oxide	Adenosine A2A receptor	MESH:D009569	11540(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|potentiates potentiates|amod|END_ENTITY	Adenosine_A2A_receptor stimulation potentiates nitric_oxide release by activated microglia .
10063925	0	nitric_oxide	112,124	Adrenomedullin	0,14	nitric oxide	Adrenomedullin	MESH:D009569	133	Chemical	Gene	relationship|nmod|START_ENTITY END_ENTITY|dep|relationship	Adrenomedullin , a vasodilator peptide implicated in hemodynamic alterations of liver_cirrhosis : relationship to nitric_oxide .
10615404	0	nitric_oxide	24,36	Adrenomedullin	0,14	nitric oxide	Adrenomedullin	MESH:D009569	25026(Tax:10116)	Chemical	Gene	synthesis|compound|START_ENTITY augments|dobj|synthesis augments|nsubj|END_ENTITY	Adrenomedullin augments nitric_oxide and tetrahydrobioptein synthesis in cytokine-stimulated vascular smooth muscle cells .
12648439	0	nitric_oxide	34,46	Adrenomedullin	0,14	nitric oxide	Adrenomedullin	MESH:D009569	25026(Tax:10116)	Chemical	Gene	system|amod|START_ENTITY requires|dobj|system requires|nsubj|END_ENTITY	Adrenomedullin requires an intact nitric_oxide system to function as an endogenous vasodilator in rat gestation .
15370692	0	nitric_oxide	102,114	Adrenomedullin	0,14	nitric oxide	Adrenomedullin	MESH:D009569	25026(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY ascites|nmod|release vascular_hyporeactivity|nmod|ascites contributes|xcomp|vascular_hyporeactivity contributes|nsubj|END_ENTITY	Adrenomedullin contributes to vascular_hyporeactivity in cirrhotic rats with ascites via a release of nitric_oxide .
16160609	0	nitric_oxide	80,92	Adrenomedullin	0,14	nitric oxide	Adrenomedullin	MESH:D009569	133	Chemical	Gene	synthesis|amod|START_ENTITY inhibition|nmod|synthesis effects|nmod|inhibition causes|parataxis|effects causes|nsubj|END_ENTITY	Adrenomedullin causes coronary vasodilation in humans : effects of inhibition of nitric_oxide synthesis .
16715121	0	nitric_oxide	24,36	Adrenomedullin	0,14	nitric oxide	Adrenomedullin	MESH:D009569	25026(Tax:10116)	Chemical	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	Adrenomedullin acts via nitric_oxide and peroxynitrite to protect against myocardial_ischaemia-induced arrhythmias in anaesthetized rats .
17446268	0	nitric_oxide	26,38	Adrenomedullin	0,14	nitric oxide	Adrenomedullin	MESH:D009569	25026(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Adrenomedullin stimulates nitric_oxide production from primary rat hypothalamic neurons : roles of calcium and phosphatases .
20172553	0	nitric_oxide	31,43	Adrenomedullin	0,14	nitric oxide	Adrenomedullin	MESH:D009569	11535(Tax:10090)	Chemical	Gene	production|compound|START_ENTITY increases|dobj|production increases|nsubj|END_ENTITY	Adrenomedullin increases renal nitric_oxide production and ameliorates renal_injury in mice with unilateral ureteral_obstruction .
20798523	0	nitric_oxide	72,84	Adrenomedullin	0,14	nitric oxide	Adrenomedullin	MESH:D009569	133	Chemical	Gene	deficiency|compound|START_ENTITY model|nmod|deficiency cardio-protective|nmod|model cardio-protective|nsubj|delivery delivery|compound|END_ENTITY	Adrenomedullin gene delivery is cardio-protective in a model of chronic nitric_oxide deficiency combining pressure overload , oxidative stress and cardiomyocyte hypertrophy .
8921801	0	nitric_oxide	34,46	Adrenomedullin	0,14	nitric oxide	Adrenomedullin	MESH:D009569	133	Chemical	Gene	expression|amod|START_ENTITY inducible|dobj|expression inducible|nsubj|augments augments|compound|END_ENTITY	Adrenomedullin augments inducible nitric_oxide synthase expression in cytokine-stimulated cardiac myocytes .
22989604	0	nitric_oxide	34,46	Akt	76,79	nitric oxide	Akt	MESH:D009569	24185(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Acute exercise induce endothelial nitric_oxide synthase phosphorylation via Akt and AMP-activated protein kinase in aorta of rats : Role of reactive_oxygen_species .
10486285	0	nitric_oxide	41,53	Alpha-MSH	0,9	nitric oxide	Alpha-MSH	MESH:D009569	18976(Tax:10090)	Chemical	Gene	factor-alpha|compound|START_ENTITY production|nmod|factor-alpha inhibit|dobj|production inhibit|nsubj|peptides peptides|compound|END_ENTITY	Alpha-MSH peptides inhibit production of nitric_oxide and tumor necrosis factor-alpha by microglial cells activated with beta-amyloid and interferon_gamma .
18957536	0	nitric_oxide	56,68	Angiopoietin-2	0,14	nitric oxide	Angiopoietin-2	MESH:D009569	285	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	Angiopoietin-2 is associated with decreased endothelial nitric_oxide and poor clinical outcome in severe falciparum_malaria .
19461044	0	nitric_oxide	88,100	Angiopoietin-2	0,14	nitric oxide	Angiopoietin-2	MESH:D009569	11601(Tax:10090)	Chemical	Gene	oxidation|nmod|START_ENTITY inhibiting|dobj|oxidation confers|advcl|inhibiting confers|nsubj|END_ENTITY	Angiopoietin-2 confers Atheroprotection in apoE - / - mice by inhibiting LDL oxidation via nitric_oxide .
21481898	0	nitric_oxide	23,35	Angiotensin-II	0,14	nitric oxide	Angiotensin-II	MESH:D009569	183	Chemical	Gene	START_ENTITY|nsubj|induced induced|compound|END_ENTITY	Angiotensin-II induced nitric_oxide production during buffalo sperm capacitation and acrosome_reaction .
9426302	0	nitric_oxide	26,38	Angiotensin-II	0,14	nitric oxide	Angiotensin-II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Angiotensin-II stimulates nitric_oxide release in isolated perfused renal resistance arteries .
10652192	0	nitric_oxide	173,185	Angiotensin-converting_enzyme	0,29	nitric oxide	Angiotensin-converting enzyme	MESH:D009569	24310(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY inhibition|nmod|synthesis induced|nmod|inhibition cardiovascular_remodeling|dep|induced prevents|advcl|cardiovascular_remodeling prevents|nsubj|inhibitor inhibitor|amod|END_ENTITY	Angiotensin-converting_enzyme inhibitor prevents plasminogen_activator_inhibitor-1 expression in a rat model with cardiovascular_remodeling induced by chronic inhibition of nitric_oxide synthesis .
16213264	0	nitric_oxide	59,71	Angiotensin-converting_enzyme	0,29	nitric oxide	Angiotensin-converting enzyme	MESH:D009569	1636	Chemical	Gene	START_ENTITY|nsubj|constitutive constitutive|amod|END_ENTITY	Angiotensin-converting_enzyme and endothelial constitutive nitric_oxide synthase polymorphisms in Turkish renal_transplant_population and possible influence on renal artery_atherosclerosis and graft survival .
9293967	0	nitric_oxide	49,61	Angiotensin-converting_enzyme	0,29	nitric oxide	Angiotensin-converting enzyme	MESH:D009569	1636	Chemical	Gene	production|amod|START_ENTITY promote|dobj|production promote|nsubj|inhibitors inhibitors|amod|END_ENTITY	Angiotensin-converting_enzyme inhibitors promote nitric_oxide production in coronary microvessels from failing explanted human hearts .
10200991	0	nitric_oxide	51,63	Angiotensin_II	0,14	nitric oxide	Angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Angiotensin_II inhibits interleukin-1_beta-induced nitric_oxide production in cultured rat mesangial cells .
10495784	0	nitric_oxide	34,46	Angiotensin_II	0,14	nitric oxide	Angiotensin II	MESH:D009569	11606(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY inhibits|dobj|synthase inhibits|nsubj|END_ENTITY	Angiotensin_II inhibits inducible nitric_oxide synthase in tubular MCT cells by a posttranscriptional mechanism .
10545435	0	nitric_oxide	111,123	Angiotensin_II	0,14	nitric oxide	Angiotensin II	MESH:D009569	11606(Tax:10090)	Chemical	Gene	synthesis|amod|START_ENTITY inhibition|nmod|synthesis activates|nmod|inhibition activates|nsubj|END_ENTITY	Angiotensin_II activates collagen type I gene in the renal vasculature of transgenic_mice during inhibition of nitric_oxide synthesis : evidence for an endothelin-mediated mechanism .
11159720	0	nitric_oxide	30,42	Angiotensin_II	0,14	nitric oxide	Angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY involved|nmod|synthase involved|nsubjpass|END_ENTITY	Angiotensin_II is involved in nitric_oxide synthase and cyclo-oxygenase inhibition-induced leukocyte-endothelial cell interactions in vivo .
11228101	0	nitric_oxide	36,48	Angiotensin_II	0,14	nitric oxide	Angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY increases|dobj|metabolism increases|nsubj|END_ENTITY	Angiotensin_II increases neurogenic nitric_oxide metabolism in mesenteric arteries from hypertensive rats .
12087347	0	nitric_oxide	55,67	Angiotensin_II	0,14	nitric oxide	Angiotensin II	MESH:D009569	183	Chemical	Gene	donor|amod|START_ENTITY effect|nmod|donor attenuates|dobj|effect attenuates|nsubj|END_ENTITY	Angiotensin_II attenuates the vasodilating effect of a nitric_oxide donor , glyceryl_trinitrate : roles of superoxide and angiotensin_II type 1 receptors .
12763763	0	nitric_oxide	106,118	Angiotensin_II	0,14	nitric oxide	Angiotensin II	MESH:D009569	183	Chemical	Gene	availability|amod|START_ENTITY decrement|nmod|availability inhibits|nmod|decrement inhibits|nsubj|END_ENTITY	Angiotensin_II inhibits endothelial cell motility through an AT1-dependent oxidant-sensitive decrement of nitric_oxide availability .
15044323	0	nitric_oxide	77,89	Angiotensin_II	0,14	nitric oxide	Angiotensin II	MESH:D009569	183	Chemical	Gene	cells|amod|START_ENTITY production|nmod|cells promoting|dobj|production signaling|advcl|promoting insulin|acl|signaling impairs|dobj|insulin impairs|nsubj|END_ENTITY	Angiotensin_II impairs the insulin signaling pathway promoting production of nitric_oxide by inducing phosphorylation of insulin_receptor_substrate-1 on Ser312 and Ser616 in human umbilical vein endothelial cells .
15155270	0	nitric_oxide	26,38	Angiotensin_II	0,14	nitric oxide	Angiotensin II	MESH:D009569	183	Chemical	Gene	production|amod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates nitric_oxide production in pulmonary artery endothelium via the type 2 receptor .
15728793	0	nitric_oxide	24,36	Angiotensin_II	0,14	nitric oxide	Angiotensin II	MESH:D009569	183	Chemical	Gene	expression|amod|START_ENTITY elevates|dobj|expression elevates|nsubj|END_ENTITY	Angiotensin_II elevates nitric_oxide synthase 3 expression and nitric_oxide production via a mitogen-activated protein kinase cascade in ovine fetoplacental artery endothelial cells .
15790666	0	nitric_oxide	97,109	Angiotensin_II	0,14	nitric oxide	Angiotensin II	MESH:D009569	183	Chemical	Gene	interactions|nmod|START_ENTITY regulation|dep|interactions regulation|compound|END_ENTITY	Angiotensin_II regulation of ovine fetoplacental artery endothelial functions : interactions with nitric_oxide .
17081374	0	nitric_oxide	53,65	Angiotensin_II	1,15	nitric oxide	Angiotensin II	MESH:D009569	183	Chemical	Gene	synthase|compound|START_ENTITY expression|nmod|synthase expression|compound|END_ENTITY	-LSB- Angiotensin_II up-regulates expression of inducible nitric_oxide synthase in human umbilical endothelial cells : roles of AT1 and AT2 -RSB- .
17082724	0	nitric_oxide	106,118	Angiotensin_II	0,14	nitric oxide	Angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	kinase|amod|START_ENTITY involves|dobj|kinase END_ENTITY|parataxis|involves	Angiotensin_II / AT2 receptor-induced vasodilation in stroke-prone spontaneously hypertensive rats involves nitric_oxide and cGMP-dependent protein kinase .
19075094	0	nitric_oxide	25,37	Angiotensin_II	0,14	nitric oxide	Angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY decreases|dobj|expression decreases|nsubj|END_ENTITY	Angiotensin_II decreases nitric_oxide synthase 3 expression via nitric_oxide and superoxide in the thick ascending limb .
19075094	0	nitric_oxide	64,76	Angiotensin_II	0,14	nitric oxide	Angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY decreases|dobj|expression decreases|nsubj|END_ENTITY	Angiotensin_II decreases nitric_oxide synthase 3 expression via nitric_oxide and superoxide in the thick ascending limb .
19934023	0	nitric_oxide	92,104	Angiotensin_II	0,14	nitric oxide	Angiotensin II	MESH:D009569	11606(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY phosphorylation|nmod|synthase function|nmod|phosphorylation impairs|dobj|function impairs|nsubj|END_ENTITY	Angiotensin_II impairs endothelial function via tyrosine phosphorylation of the endothelial nitric_oxide synthase .
20056918	0	nitric_oxide	33,45	Angiotensin_II	0,14	nitric oxide	Angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	activation|amod|START_ENTITY inhibits|dobj|activation inhibits|nsubj|END_ENTITY	Angiotensin_II inhibits neuronal nitric_oxide synthase activation through the ERK1/2-RSK signaling pathway to modulate central control of blood pressure .
21358315	0	nitric_oxide	71,83	Angiotensin_II	0,14	nitric oxide	Angiotensin II	MESH:D009569	183	Chemical	Gene	START_ENTITY|nsubj|upregulation upregulation|compound|END_ENTITY	Angiotensin_II upregulation of cardiomyocyte adiponectin production is nitric_oxide / cyclic_GMP dependent .
24511122	0	nitric_oxide	88,100	Angiotensin_II	0,14	nitric oxide	Angiotensin II	MESH:D009569	183	Chemical	Gene	transport|nmod|START_ENTITY stimulates|dobj|transport stimulates|nsubj|END_ENTITY	Angiotensin_II dose-dependently stimulates human renal proximal tubule transport by the nitric_oxide / guanosine_3 ' ,5 ' - cyclic_monophosphate pathway .
26884476	0	nitric_oxide	51,63	Angiotensin_II	0,14	nitric oxide	Angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY stimulates|nmod|synthase stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates superoxide production by nitric_oxide synthase in thick ascending limbs .
7512570	0	nitric_oxide	54,66	Angiotensin_II	0,14	nitric oxide	Angiotensin II	MESH:D009569	183	Chemical	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Angiotensin_II inhibits cytokine-stimulated inducible nitric_oxide synthase expression in vascular smooth muscle cells .
7512740	0	nitric_oxide	88,100	Angiotensin_II	0,14	nitric oxide	Angiotensin II	MESH:D009569	183	Chemical	Gene	inhibitor|amod|START_ENTITY potentiated|nmod|inhibitor potentiated|nsubjpass|actions actions|compound|END_ENTITY	Angiotensin_II neurotransmitter actions in paraventricular nucleus are potentiated by a nitric_oxide synthase inhibitor .
7534984	0	nitric_oxide	35,47	Angiotensin_II	0,14	nitric oxide	Angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY decreases|dobj|expression decreases|nsubj|END_ENTITY	Angiotensin_II decreases inducible nitric_oxide synthase expression in rat astroglial cultures .
7586373	0	nitric_oxide	44,56	Angiotensin_II	0,14	nitric oxide	Angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	synthesis|compound|START_ENTITY augments|dobj|synthesis augments|nsubj|END_ENTITY	Angiotensin_II augments cytokine-stimulated nitric_oxide synthesis in rat cardiac myocytes .
8011977	0	nitric_oxide	36,48	Angiotensin_II	0,14	nitric oxide	Angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	interaction|compound|START_ENTITY END_ENTITY|dep|interaction	Angiotensin_II : endothelium-derived nitric_oxide interaction in conscious rats .
8285267	0	nitric_oxide	16,28	Angiotensin_II	0,14	nitric oxide	Angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	interaction|amod|START_ENTITY END_ENTITY|dep|interaction	Angiotensin_II : nitric_oxide interaction and the distribution of blood_flow .
9453317	0	nitric_oxide	51,63	Angiotensin_II	0,14	nitric oxide	Angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	synthase|compound|START_ENTITY synthesis|nmod|synthase stimulates|dobj|synthesis stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates synthesis of endothelial nitric_oxide synthase .
16778335	0	nitric_oxide	122,134	Angiotensin_II_type_1_receptor	0,30	nitric oxide	Angiotensin II type 1 receptor	MESH:D009569	81638(Tax:10116)	Chemical	Gene	inhibition|compound|START_ENTITY induced|nmod|inhibition hypertension|acl|induced atrial_structural_remodeling|nmod|hypertension prevents|xcomp|atrial_structural_remodeling prevents|nsubj|blocker blocker|amod|END_ENTITY	Angiotensin_II_type_1_receptor blocker prevents atrial_structural_remodeling in rats with hypertension induced by chronic nitric_oxide inhibition .
17993594	0	nitric_oxide	59,71	Angiotensin_II_type_1_receptor	0,30	nitric oxide	Angiotensin II type 1 receptor	MESH:D009569	185	Chemical	Gene	deficit|compound|START_ENTITY corrects|dobj|deficit corrects|nsubj|blockade blockade|amod|END_ENTITY	Angiotensin_II_type_1_receptor blockade corrects cutaneous nitric_oxide deficit in postural_tachycardia_syndrome .
18596126	0	nitric_oxide	73,85	Angiotensin_II_type_1_receptor	0,30	nitric oxide	Angiotensin II type 1 receptor	MESH:D009569	81638(Tax:10116)	Chemical	Gene	synthase|compound|START_ENTITY uncoupled|dobj|synthase uncoupled|nsubj|ameliorates ameliorates|amod|END_ENTITY	Angiotensin_II_type_1_receptor blocker ameliorates uncoupled endothelial nitric_oxide synthase in rats with experimental diabetic_nephropathy .
21937042	0	nitric_oxide	92,104	Angiotensin_II_type_1_receptor	0,30	nitric oxide	Angiotensin II type 1 receptor	MESH:D009569	185	Chemical	Gene	production|compound|START_ENTITY interferes|nmod|production interferes|nsubj|END_ENTITY	Angiotensin_II_type_1_receptor , but no type 2 receptor , interferes with the insulin-induced nitric_oxide production in HUVECs .
7594419	0	nitric_oxide	36,48	Atrial_natriuretic_factor	0,25	nitric oxide	Atrial natriuretic factor	MESH:D009569	4878	Chemical	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	Atrial_natriuretic_factor modulates nitric_oxide production : an ANF-C receptor-mediated effect .
10818074	0	nitric_oxide	68,80	Atrial_natriuretic_peptide	0,26	nitric oxide	Atrial natriuretic peptide	MESH:D009569	24602(Tax:10116)	Chemical	Gene	pathway|amod|START_ENTITY modifies|nmod|pathway modifies|nsubj|END_ENTITY	Atrial_natriuretic_peptide modifies arterial blood pressure through nitric_oxide pathway in rats .
15003831	0	nitric_oxide	40,52	Atrial_natriuretic_peptide	0,26	nitric oxide	Atrial natriuretic peptide	MESH:D009569	24602(Tax:10116)	Chemical	Gene	system|amod|START_ENTITY influence|nmod|system influence|nsubj|END_ENTITY	Atrial_natriuretic_peptide influence on nitric_oxide system in kidney and heart .
7869823	0	nitric_oxide	36,48	Atrial_natriuretic_peptide	0,26	nitric oxide	Atrial natriuretic peptide	MESH:D009569	230899(Tax:10090)	Chemical	Gene	synthesis|amod|START_ENTITY inhibits|dobj|synthesis inhibits|nsubj|END_ENTITY	Atrial_natriuretic_peptide inhibits nitric_oxide synthesis in mouse macrophages .
9661135	0	nitric_oxide	57,69	Atrial_natriuretic_peptide	0,26	nitric oxide	Atrial natriuretic peptide	MESH:D009569	24602(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	Atrial_natriuretic_peptide enhances IL-1_beta-stimulated nitric_oxide production in cultured rat vascular smooth muscle cells .
16002567	0	nitric_oxide	87,99	BNIP3	37,42	nitric oxide	BNIP3	MESH:D009569	664	Chemical	Gene	regulation|nmod|START_ENTITY expression|dep|regulation expression|nmod|END_ENTITY	Intestinal and hepatic expression of BNIP3 in necrotizing_enterocolitis : regulation by nitric_oxide and peroxynitrite .
11956566	0	nitric_oxide	41,53	Basic_fibroblast_growth_factor	0,30	nitric oxide	Basic fibroblast growth factor	MESH:D009569	54250(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY increases|dobj|production increases|nsubj|END_ENTITY	Basic_fibroblast_growth_factor increases nitric_oxide and endothelin production in rat aorta .
16777344	0	nitric_oxide	185,197	Bax	16,19	nitric oxide	Bax	MESH:D009569	581	Chemical	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Hypoxia-induced Bax and Bcl-2 protein expression , caspase-9 activation , DNA fragmentation , and lipid peroxidation in mitochondria of the cerebral cortex of newborn piglets : the role of nitric_oxide .
10537063	0	nitric_oxide	95,107	Bcl-2	59,64	nitric oxide	Bcl-2	MESH:D009569	596	Chemical	Gene	induced|nmod|START_ENTITY expression|acl|induced expression|amod|END_ENTITY	Activation of Akt kinase inhibits apoptosis and changes in Bcl-2 and Bax expression induced by nitric_oxide in primary hippocampal neurons .
20184889	0	nitric_oxide	36,48	Beta_3-adrenoreceptor	0,21	nitric oxide	Beta 3-adrenoreceptor	MESH:D009569	155	Chemical	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Beta_3-adrenoreceptor regulation of nitric_oxide in the cardiovascular system .
20096286	0	nitric_oxide	79,91	Biglycan	0,8	nitric oxide	Biglycan	MESH:D009569	25181(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY protects|parataxis|role protects|nsubj|END_ENTITY	Biglycan protects cardiomyocytes against hypoxia/reoxygenation injury : role of nitric_oxide .
11791011	0	nitric_oxide	102,114	Bradykinin	0,10	nitric oxide	Bradykinin	MESH:D009569	3827	Chemical	Gene	inducing|dobj|START_ENTITY inhibits|advcl|inducing inhibits|nsubj|END_ENTITY	Bradykinin inhibits serum-depletion-induced apoptosis of human vascular endothelial cells by inducing nitric_oxide via calcium ion kinetics .
23340021	0	nitric_oxide	21,33	Bradykinin	0,10	nitric oxide	Bradykinin	MESH:D009569	3827	Chemical	Gene	release|amod|START_ENTITY decreases|dobj|release decreases|nsubj|END_ENTITY	Bradykinin decreases nitric_oxide release from microglia via inhibition of cyclic_adenosine_monophosphate signaling .
24839774	0	nitric_oxide	26,38	Bradykinin	0,10	nitric oxide	Bradykinin	MESH:D009569	3827	Chemical	Gene	production|amod|START_ENTITY stimulation|nmod|production stimulation|compound|END_ENTITY	Bradykinin stimulation of nitric_oxide production is not sufficient for gamma-globin induction .
8832059	0	nitric_oxide	89,101	Bradykinin	0,10	nitric oxide	Bradykinin	MESH:D009569	3827	Chemical	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Bradykinin and changes in microvascular permeability in the hamster cheek pouch : role of nitric_oxide .
9415011	0	nitric_oxide	116,128	Bradykinin	0,10	nitric oxide	Bradykinin	MESH:D009569	3827	Chemical	Gene	synthesis|amod|START_ENTITY inhibition|nmod|synthesis effect|nmod|inhibition END_ENTITY|dep|effect	Bradykinin induced dilatation of human epicardial and resistance coronary arteries in vivo : effect of inhibition of nitric_oxide synthesis .
12021818	0	nitric_oxide	31,43	C-fos	0,5	nitric oxide	C-fos	MESH:D009569	314322(Tax:10116)	Chemical	Gene	immunoreactive|amod|START_ENTITY expressions|nmod|immunoreactive expressions|amod|END_ENTITY	C-fos and c-jun expressions in nitric_oxide synthase immunoreactive neurons in the lateral geniculate nucleus of experimental glaucomatous rats .
23085209	0	nitric_oxide	81,93	C/EBPb	112,118	nitric oxide	C/EBPb	MESH:D009569	24253(Tax:10116)	Chemical	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Gomisin_N in the herbal drug gomishi -LRB- Schisandra chinensis -RRB- suppresses inducible nitric_oxide synthase gene via C/EBPb and NF-kB in rat hepatocytes .
11086993	0	nitric_oxide	54,66	CAPON	80,85	nitric oxide	CAPON	MESH:D009569	70729(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY synthase|nmod|END_ENTITY	Dexras1 : a G protein specifically coupled to neuronal nitric_oxide synthase via CAPON .
20174726	0	nitric_oxide	81,93	CD-34	132,137	nitric oxide	CD-34	MESH:D009569	947	Chemical	Gene	synthase|amod|START_ENTITY synthase|amod|END_ENTITY	Expression of cyclooxygenase-2 and its relation to histological grade , inducible nitric_oxide synthase , matrix_metalloproteinase-2 , CD-34 , Caspase-3 , and CD8 in invasive_ductal_carcinoma of the breast .
16551637	0	nitric_oxide	48,60	CD11b	28,33	nitric oxide	CD11b	MESH:D009569	3684	Chemical	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|expression expression|amod|END_ENTITY	Up-regulation of microglial CD11b expression by nitric_oxide .
19572148	0	nitric_oxide	52,64	CD14	91,95	nitric oxide	CD14	MESH:D009569	929	Chemical	Gene	CD11b|amod|START_ENTITY alterations|nmod|CD11b +|nsubj|alterations +|dep|+ +|compound|END_ENTITY	Population alterations of L-arginase - and inducible nitric_oxide synthase-expressed CD11b + / CD14 / CD15 + / CD33 + myeloid-derived suppressor cells and CD8 + T lymphocytes in patients with advanced-stage non-small_cell_lung_cancer .
8598386	0	nitric_oxide	36,48	CD14	0,4	nitric oxide	CD14	MESH:D009569	60350(Tax:10116)	Chemical	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	CD14 mediate endotoxin induction of nitric_oxide synthase in cultured brain glial cells .
19572148	0	nitric_oxide	52,64	CD15	99,103	nitric oxide	CD15	MESH:D009569	2526	Chemical	Gene	CD11b|amod|START_ENTITY alterations|nmod|CD11b +|nsubj|alterations +|dep|+ +|compound|END_ENTITY	Population alterations of L-arginase - and inducible nitric_oxide synthase-expressed CD11b + / CD14 / CD15 + / CD33 + myeloid-derived suppressor cells and CD8 + T lymphocytes in patients with advanced-stage non-small_cell_lung_cancer .
17416590	0	nitric_oxide	26,38	CD36	53,57	nitric oxide	CD36	MESH:D009569	948	Chemical	Gene	START_ENTITY|xcomp|signaling signaling|nmod|END_ENTITY	Thrombospondin-1 inhibits nitric_oxide signaling via CD36 by inhibiting myristic_acid uptake .
11147700	0	nitric_oxide	38,50	CD40L	12,17	nitric oxide	CD40L	MESH:D009569	21947(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	The role of CD40L in T cell-dependent nitric_oxide production by murine macrophages .
10233938	0	nitric_oxide	20,32	CD46	6,10	nitric oxide	CD46	MESH:D009569	17221(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	Human CD46 enhances nitric_oxide production in mouse macrophages in response to measles_virus infection in the presence of gamma interferon : dependence on the CD46 cytoplasmic domains .
11591387	0	nitric_oxide	35,47	CHOP	13,17	nitric oxide	CHOP	MESH:D009569	13198(Tax:10090)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of CHOP and apoptosis by nitric_oxide in p53-deficient microglial cells .
21813679	0	nitric_oxide	26,38	CNGA3	0,5	nitric oxide	CNGA3	MESH:D009569	12790(Tax:10090)	Chemical	Gene	target|nmod|START_ENTITY END_ENTITY|dep|target	CNGA3 : a target of spinal nitric_oxide / cGMP signaling and modulator of inflammatory_pain hypersensitivity .
10903767	0	nitric_oxide	38,50	COX-1	61,66	nitric oxide	COX-1	MESH:D009569	17708(Tax:10090)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Nitric_oxide synthase/COX cross-talk : nitric_oxide activates COX-1 but inhibits COX-2-derived prostaglandin production .
19391507	0	nitric_oxide	51,63	COX-1	15,20	nitric oxide	COX-1	MESH:D009569	26195(Tax:10116)	Chemical	Gene	-RSB-|compound|START_ENTITY inhibitors|nmod|-RSB- inhibitors|amod|END_ENTITY	-LSB- The effect of COX-1 and COX-3 inhibitors on blood nitric_oxide concentration -RSB- .
10092766	0	nitric_oxide	104,116	COX-2	26,31	nitric oxide	COX-2	MESH:D009569	17709(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY expression|nmod|effect expression|compound|END_ENTITY	Tetracycline up-regulates COX-2 expression and prostaglandin_E2 production independent of its effect on nitric_oxide .
10201946	0	nitric_oxide	65,77	COX-2	24,29	nitric oxide	COX-2	MESH:D009569	19225(Tax:10090)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of cytosolic COX-2 and prostaglandin_E2 production by nitric_oxide in activated murine macrophages .
10679307	0	nitric_oxide	33,45	COX-2	13,18	nitric oxide	COX-2	MESH:D009569	4513	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|expression expression|compound|END_ENTITY	Induction of COX-2 expression by nitric_oxide in rheumatoid synovial cells .
11350902	0	nitric_oxide	26,38	COX-2	133,138	nitric oxide	COX-2	MESH:D009569	5743	Chemical	Gene	Coexpression|nmod|START_ENTITY Coexpression|dep|involvement involvement|nmod|END_ENTITY	Coexpression of inducible nitric_oxide synthase and COX-2 in hepatocellular_carcinoma and surrounding liver : possible involvement of COX-2 in the angiogenesis of hepatitis_C_virus-positive cases .
11967238	0	nitric_oxide	48,60	COX-2	11,16	nitric oxide	COX-2	MESH:D009569	19225(Tax:10090)	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|compound|END_ENTITY	Epithelial COX-2 expression is not regulated by nitric_oxide in rodent renal cortex .
14566822	0	nitric_oxide	14,26	COX-2	48,53	nitric oxide	COX-2	MESH:D009569	5743	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|overexpression overexpression|appos|END_ENTITY	The effect of nitric_oxide on cyclooxygenase-2 -LRB- COX-2 -RRB- overexpression in head_and_neck_cancer cell lines .
15647833	0	nitric_oxide	125,137	COX-2	10,15	nitric oxide	COX-2	MESH:D009569	5743	Chemical	Gene	induction|nmod|START_ENTITY signaling|nmod|induction regulates|dep|signaling regulates|nsubj|inhibitor inhibitor|compound|END_ENTITY	Selective COX-2 inhibitor regulates the MAP kinase signaling pathway in human osteoarthritic chondrocytes after induction of nitric_oxide .
17193179	0	nitric_oxide	40,52	COX-2	78,83	nitric oxide	COX-2	MESH:D009569	4513	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	The furoxan system : design of selective nitric_oxide -LRB- NO -RRB- donor inhibitors of COX-2 endowed with anti-aggregatory and vasodilating activities .
18042295	0	nitric_oxide	126,138	COX-2	35,40	nitric oxide	COX-2	MESH:D009569	5743	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|expression expression|appos|END_ENTITY	The effects of a cyclooxygenase-2 -LRB- COX-2 -RRB- expression and inhibition on human uveal_melanoma cell proliferation and macrophage nitric_oxide production .
18097606	0	nitric_oxide	54,66	COX-2	34,39	nitric oxide	COX-2	MESH:D009569	5743	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Transcriptional regulation of the COX-2 expression by nitric_oxide in colon_cancer cell lines .
20514441	0	nitric_oxide	35,47	COX-2	120,125	nitric oxide	COX-2	MESH:D009569	4513	Chemical	Gene	inhibitors|nmod|START_ENTITY effects|nmod|inhibitors effects|acl|overexpressing overexpressing|dobj|END_ENTITY	Antitumor effects of inhibitors of nitric_oxide synthase or cyclooxygenase-2 on human KB carcinoma cells overexpressing COX-2 .
24373735	0	nitric_oxide	79,91	COX-2	62,67	nitric oxide	COX-2	MESH:D009569	5743	Chemical	Gene	donors|compound|START_ENTITY donors|compound|END_ENTITY	Enhancing the pharmacodynamic profile of a class of selective COX-2 inhibiting nitric_oxide donors .
9514898	0	nitric_oxide	23,35	CR3	16,19	nitric oxide	CR3	MESH:D009569	16409(Tax:10090)	Chemical	Gene	Contribution|acl|START_ENTITY Contribution|nmod|END_ENTITY	Contribution of CR3 to nitric_oxide production from macrophages stimulated with high-dose of LPS .
9134219	0	nitric_oxide	30,42	CREB	116,120	nitric oxide	CREB	MESH:D009569	81646(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY staurosporine|nmod|expression Induction|nmod|staurosporine cells|amod|Induction cells|dep|role role|nmod|B B|appos|beta beta|compound|END_ENTITY	Induction by staurosporine of nitric_oxide synthase expression in vascular smooth muscle cells : role of NF-kappa B , CREB and C/EBP _ beta .
19059114	0	nitric_oxide	30,42	CXCL12	0,6	nitric oxide	CXCL12	MESH:D009569	6387	Chemical	Gene	induction|nmod|START_ENTITY induction|nummod|END_ENTITY	CXCL12 induction of inducible nitric_oxide synthase in human CD8 T cells .
18221935	0	nitric_oxide	47,59	Calcitonin_gene-related_peptide	0,31	nitric oxide	Calcitonin gene-related peptide	MESH:D009569	24241(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY stimulation|nmod|synthesis stimulation|amod|END_ENTITY	Calcitonin_gene-related_peptide stimulation of nitric_oxide synthesis and release from trigeminal ganglion glial cells .
18677097	0	nitric_oxide	65,77	Calcitonin_gene-related_peptide	0,31	nitric oxide	Calcitonin gene-related peptide	MESH:D009569	12310(Tax:10090)	Chemical	Gene	currents|nmod|START_ENTITY currents|amod|END_ENTITY	Calcitonin_gene-related_peptide suppresses pacemaker currents by nitric_oxide / cGMP-dependent activation of ATP-sensitive K -LRB- + -RRB- channels in cultured interstitial cells of Cajal from the mouse small intestine .
19055511	0	nitric_oxide	111,123	Calcitonin_gene-related_peptide	0,31	nitric oxide	Calcitonin gene-related peptide	MESH:D009569	24241(Tax:10116)	Chemical	Gene	nucleus|amod|START_ENTITY increase|nmod|nucleus induced|nmod|increase activity|acl|induced reduces|dobj|activity reduces|nsubj|inhibition inhibition|amod|END_ENTITY	Calcitonin_gene-related_peptide receptor inhibition reduces neuronal activity induced by prolonged increase in nitric_oxide in the rat spinal trigeminal nucleus .
7713923	0	nitric_oxide	117,129	Calreticulin	0,12	nitric oxide	Calreticulin	MESH:D009569	12317(Tax:10090)	Chemical	Gene	production|compound|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Calreticulin , an antithrombotic agent which binds to vitamin_K-dependent coagulation factors , stimulates endothelial nitric_oxide production , and limits thrombosis in canine coronary arteries .
10696535	0	nitric_oxide	35,47	Carbonic_anhydrase_I	0,20	nitric oxide	Carbonic anhydrase I	MESH:D009569	100009083(Tax:9986)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Carbonic_anhydrase_I inhibition by nitric_oxide : implications for mediation of the hypercapnia-induced vasodilator response .
20174726	0	nitric_oxide	81,93	Caspase-3	139,148	nitric oxide	Caspase-3	MESH:D009569	836	Chemical	Gene	synthase|amod|START_ENTITY synthase|amod|END_ENTITY	Expression of cyclooxygenase-2 and its relation to histological grade , inducible nitric_oxide synthase , matrix_metalloproteinase-2 , CD-34 , Caspase-3 , and CD8 in invasive_ductal_carcinoma of the breast .
10854853	0	nitric_oxide	54,66	Catalase	0,8	nitric oxide	Catalase	MESH:D009569	24248(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|activity activity|amod|END_ENTITY	Catalase activity of oxygenase domain of rat neuronal nitric_oxide synthase .
1537380	0	nitric_oxide	18,30	Catalase	0,8	nitric oxide	Catalase	MESH:D009569	12359(Tax:10090)	Chemical	Gene	synthesis|amod|START_ENTITY inhibits|dobj|synthesis inhibits|nsubj|END_ENTITY	Catalase inhibits nitric_oxide synthesis and the killing of intracellular Leishmania_major in murine macrophages .
15683716	0	nitric_oxide	61,73	Catalase	0,8	nitric oxide	Catalase	MESH:D009569	24248(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY expression|nmod|synthase potentiates|dobj|expression potentiates|nsubj|END_ENTITY	Catalase potentiates interleukin-1beta-induced expression of nitric_oxide synthase in rat vascular smooth muscle cells .
16403660	0	nitric_oxide	55,67	Catalase	0,8	nitric oxide	Catalase	MESH:D009569	24248(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY inhibition|nmod|synthesis cardiomyocytes|nmod|inhibition protects|dobj|cardiomyocytes protects|nsubj|END_ENTITY	Catalase protects cardiomyocytes via its inhibition of nitric_oxide synthesis .
24669281	0	nitric_oxide	89,101	Catalase	0,8	nitric oxide	Catalase	MESH:D009569	24248(Tax:10116)	Chemical	Gene	action|nmod|START_ENTITY influence|dep|action influence|amod|END_ENTITY	Catalase influence in the regulation of coronary resistance by estrogen : joint action of nitric_oxide and hydrogen_peroxide .
12444009	0	nitric_oxide	63,75	Cholecystokinin	0,15	nitric oxide	Cholecystokinin	MESH:D009569	25298(Tax:10116)	Chemical	Gene	flow|compound|START_ENTITY role|nmod|flow gastroprotection|dep|role gastroprotection|amod|END_ENTITY	Cholecystokinin secretagogue-induced gastroprotection : role of nitric_oxide and blood flow .
25125801	0	nitric_oxide	35,47	Cholecystokinin	0,15	nitric oxide	Cholecystokinin	MESH:D009569	885	Chemical	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Cholecystokinin inhibits inducible nitric_oxide synthase expression by lipopolysaccharide-stimulated peritoneal macrophages .
8612510	0	nitric_oxide	117,129	Constitutive_nitric_oxide_synthase	0,34	nitric oxide	Constitutive nitric oxide synthase	MESH:D009569	24600(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Constitutive_nitric_oxide_synthase in hypothalami of normal and hereditary_diabetes_insipidus rats and mice : role of nitric_oxide in osmotic regulation and its mechanism .
8593789	0	nitric_oxide	77,89	Corticotropin-releasing_factor	0,30	nitric oxide	Corticotropin-releasing factor	MESH:D009569	81648(Tax:10116)	Chemical	Gene	restrains|amod|START_ENTITY mediate|dep|restrains mediate|nsubj|END_ENTITY	Corticotropin-releasing_factor , vasopressin , and prostaglandins mediate , and nitric_oxide restrains , the hypothalamic-pituitary-adrenal response to acute_local_inflammation in the rat .
17406074	0	nitric_oxide	26,38	Cu-Zn/SOD	53,62	nitric oxide	Cu-Zn/SOD	MESH:D009569	24786(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Effect of an inhibitor of nitric_oxide production on Cu-Zn/SOD and its cofactors in diabetic rats .
12060588	0	nitric_oxide	55,67	Cyclooxygenase-2	0,16	nitric oxide	Cyclooxygenase-2	MESH:D009569	5743	Chemical	Gene	regulation|amod|START_ENTITY inhibition|nmod|regulation compensate|nmod|inhibition compensate|nsubj|products products|amod|END_ENTITY	Cyclooxygenase-2 products compensate for inhibition of nitric_oxide regulation of renal perfusion .
15102673	0	nitric_oxide	65,77	Cyclooxygenase-2	0,16	nitric oxide	Cyclooxygenase-2	MESH:D009569	5743	Chemical	Gene	effect|nmod|START_ENTITY mediates|dobj|effect mediates|nsubj|activation activation|amod|END_ENTITY	Cyclooxygenase-2 activation mediates the proangiogenic effect of nitric_oxide in colorectal_cancer .
22554772	0	nitric_oxide	72,84	Cyclooxygenase-2	0,16	nitric oxide	Cyclooxygenase-2	MESH:D009569	29527(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY mediate|nmod|activity prostaglandins|xcomp|mediate prostaglandins|nsubj|END_ENTITY	Cyclooxygenase-2 prostaglandins mediate anandamide-inhibitory action on nitric_oxide synthase activity in the receptive rat uterus .
11211108	0	nitric_oxide	30,42	Cyclooxygenase_2	0,16	nitric oxide	Cyclooxygenase 2	MESH:D009569	29527(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Cyclooxygenase_2 and neuronal nitric_oxide synthase expression in the renal cortex are not interdependent in states of salt_deficiency .
15526382	0	nitric_oxide	33,45	Cyclooxygenase_2	0,16	nitric oxide	Cyclooxygenase 2	MESH:D009569	29527(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY inducible|dobj|synthase inducible|nsubj|END_ENTITY	Cyclooxygenase_2 , pS2 , inducible nitric_oxide synthase and transforming_growth_factor_alpha in gastric adaptation to stress .
16585199	0	nitric_oxide	128,140	Cyclooxygenase_2	0,16	nitric oxide	Cyclooxygenase 2	MESH:D009569	5743	Chemical	Gene	activity|amod|START_ENTITY inhibition|nmod|activity mechanism|nmod|inhibition rescues|nmod|mechanism rescues|nsubj|END_ENTITY	Cyclooxygenase_2 rescues LNCaP_prostate_cancer cells from sanguinarine-induced apoptosis by a mechanism involving inhibition of nitric_oxide synthase activity .
17164295	0	nitric_oxide	86,98	Cytochrome_c	0,12	nitric oxide	Cytochrome c	MESH:D009569	54205	Chemical	Gene	maintains|nmod|START_ENTITY maintains|nsubj|oxidase oxidase|amod|END_ENTITY	Cytochrome_c oxidase maintains mitochondrial respiration during partial inhibition by nitric_oxide .
7626092	0	nitric_oxide	51,63	Cytochrome_c	0,12	nitric oxide	Cytochrome c	MESH:D009569	104968582	Chemical	Gene	reduction|nmod|START_ENTITY catalysis|nmod|reduction oxidase|dobj|catalysis oxidase|nsubj|END_ENTITY	Cytochrome_c oxidase catalysis of the reduction of nitric_oxide to nitrous_oxide .
8928869	0	nitric_oxide	11,23	EDRF	24,28	nitric oxide	EDRF	MESH:D009569	51327	Chemical	Gene	Effects|nmod|START_ENTITY Effects|dep|END_ENTITY	Effects of nitric_oxide / EDRF on platelet surface glycoproteins .
21570464	0	nitric_oxide	74,86	EMMPRIN	51,58	nitric oxide	EMMPRIN	MESH:D009569	12215(Tax:10090)	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	The extracellular matrix metalloproteinase inducer EMMPRIN is a target of nitric_oxide in myocardial_ischemia / reperfusion .
25465108	0	nitric_oxide	12,24	ENOS	136,140	nitric oxide	ENOS	MESH:D009569	4846	Chemical	Gene	Efficacy|dep|START_ENTITY trial|dep|Efficacy trial|nmod|treatment treatment|nmod|management management|nmod|pressure pressure|nmod|acute_stroke acute_stroke|appos|END_ENTITY	Efficacy of nitric_oxide , with or without continuing antihypertensive treatment , for management of high blood pressure in acute_stroke -LRB- ENOS -RRB- : a partial-factorial randomised controlled trial .
15843443	0	nitric_oxide	16,28	ENaC	43,47	nitric oxide	ENaC	MESH:D009569	20276(Tax:10090)	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Role of SGK1 in nitric_oxide inhibition of ENaC in Na + - transporting epithelia .
15257469	0	nitric_oxide	46,58	EPX	71,74	nitric oxide	EPX	MESH:D009569	8288	Chemical	Gene	excretion|amod|START_ENTITY excretion|compound|END_ENTITY	-LSB- Effect of two doses of budesonide on exhaled nitric_oxide and urinary EPX excretion in asthmatic children -RSB- .
10586030	0	nitric_oxide	169,181	ERK	292,295	nitric oxide	ERK	MESH:D009569	5594	Chemical	Gene	START_ENTITY|ccomp|subvert subvert|advcl|targeting targeting|xcomp|kinase kinase|nsubj|MAP MAP|compound|END_ENTITY	Extracellular_signal-related_kinase -LRB- ERK -RRB- and p38 mitogen-activated protein -LRB- MAP -RRB- kinases differentially regulate the lipopolysaccharide-mediated induction of inducible nitric_oxide synthase and IL-12 in macrophages : Leishmania phosphoglycans subvert macrophage IL-12 production by targeting ERK MAP kinase .
10586030	0	nitric_oxide	169,181	ERK	37,40	nitric oxide	ERK	MESH:D009569	5594	Chemical	Gene	regulate|ccomp|START_ENTITY regulate|nsubj|Extracellular_signal-related_kinase Extracellular_signal-related_kinase|appos|END_ENTITY	Extracellular_signal-related_kinase -LRB- ERK -RRB- and p38 mitogen-activated protein -LRB- MAP -RRB- kinases differentially regulate the lipopolysaccharide-mediated induction of inducible nitric_oxide synthase and IL-12 in macrophages : Leishmania phosphoglycans subvert macrophage IL-12 production by targeting ERK MAP kinase .
11536169	0	nitric_oxide	60,72	ERK	97,100	nitric oxide	ERK	MESH:D009569	5594	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Group IIA secretory phospholipase A -LRB- 2 -RRB- stimulates inducible nitric_oxide synthase expression via ERK and NF-kappaB in macrophages .
11931846	0	nitric_oxide	102,114	ERK	62,65	nitric oxide	ERK	MESH:D009569	5594	Chemical	Gene	synthesis|compound|START_ENTITY Lack|nmod|synthesis Lack|appos|END_ENTITY	Lack of involvement of extracellular_signal-regulated_kinase -LRB- ERK -RRB- in the agonist-induced endothelial nitric_oxide synthesis .
17170076	0	nitric_oxide	97,109	ERK	137,140	nitric oxide	ERK	MESH:D009569	5594	Chemical	Gene	generation|compound|START_ENTITY gamma|dep|generation Role|dep|gamma Role|dep|implication implication|nmod|pathway pathway|compound|END_ENTITY	Role of protein tyrosine phosphatases in the regulation of interferon - -LCB- gamma -RCB- - induced macrophage nitric_oxide generation : implication of ERK pathway and AP-1 activation .
18523870	0	nitric_oxide	10,22	ERK	71,74	nitric oxide	ERK	MESH:D009569	26413(Tax:10090)	Chemical	Gene	donor|amod|START_ENTITY donor|nmod|modifications modifications|nmod|END_ENTITY	Effect of nitric_oxide donor and gamma irradiation on modifications of ERK and JNK in murine peritoneal macrophages .
19111870	0	nitric_oxide	20,32	ERK	46,49	nitric oxide	ERK	MESH:D009569	5594	Chemical	Gene	START_ENTITY|dep|signaling signaling|nsubj|increase increase|nmod|END_ENTITY	Catalpol attenuates nitric_oxide increase via ERK signaling pathways induced by rotenone in mesencephalic neurons .
19133325	0	nitric_oxide	27,39	ERK	124,127	nitric oxide	ERK	MESH:D009569	24338(Tax:10116)	Chemical	Gene	signaling|amod|START_ENTITY transduction|nmod|signaling transduction|dep|effects effects|nmod|regulation regulation|nmod|pathway pathway|compound|END_ENTITY	Fatty_acid transduction of nitric_oxide signaling : nitrolinoleic_acid mediates protective effects through regulation of the ERK pathway .
19968502	0	nitric_oxide	56,68	ERK	125,128	nitric oxide	ERK	MESH:D009569	5594	Chemical	Gene	levels|amod|START_ENTITY increases|dobj|levels increases|nmod|mechanism mechanism|nmod|pathway pathway|compound|END_ENTITY	Limonene exerts antiproliferative effects and increases nitric_oxide levels on a lymphoma cell line by dual mechanism of the ERK pathway : relationship with oxidative stress .
20649843	0	nitric_oxide	38,50	ERK	83,86	nitric oxide	ERK	MESH:D009569	24338(Tax:10116)	Chemical	Gene	cyclic_GMP|amod|START_ENTITY cyclic_GMP|acl|signaling signaling|nmod|END_ENTITY	Midbrain dopaminergic neurons utilize nitric_oxide / cyclic_GMP signaling to recruit ERK that links retinoic_acid receptor stimulation to up-regulation of BDNF .
25000310	0	nitric_oxide	12,24	ERK	50,53	nitric oxide	ERK	MESH:D009569	5594	Chemical	Gene	synthase|compound|START_ENTITY regulated|nsubjpass|synthase regulated|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Endothelial nitric_oxide synthase is regulated by ERK phosphorylation at Ser602 .
16547595	0	nitric_oxide	69,81	ERK1/2	8,14	nitric oxide	ERK1/2	MESH:D009569	26417;26413	Chemical	Gene	effects|nmod|START_ENTITY Role|nmod|effects Role|nmod|END_ENTITY	Role of ERK1/2 in the anti-apoptotic and cardioprotective effects of nitric_oxide after myocardial_ischemia and reperfusion .
8843723	0	nitric_oxide	74,86	ETB	53,56	nitric oxide	ETB	MESH:D009569	50672(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY release|compound|END_ENTITY	Thrombin-induced vascular reactivity is modulated by ETB receptor-coupled nitric_oxide release in rat aorta .
12595592	0	nitric_oxide	97,109	Endostatin	0,10	nitric oxide	Endostatin	MESH:D009569	80781	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|dep|effect	Endostatin and vascular endothelial cell growth factor -LRB- VEGF -RRB- in piglet lungs : effect of inhaled nitric_oxide and hyperoxia .
15540202	0	nitric_oxide	20,32	Endostatin	0,10	nitric oxide	Endostatin	MESH:D009569	80781	Chemical	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Endostatin inhibits nitric_oxide and diminishes VEGF and collagen_XVIII in squamous_carcinoma cells .
22733742	0	nitric_oxide	37,49	Endostatin	0,10	nitric oxide	Endostatin	MESH:D009569	12822(Tax:10090)	Chemical	Gene	pressure|nmod|START_ENTITY lowers|dobj|pressure lowers|nsubj|END_ENTITY	Endostatin lowers blood pressure via nitric_oxide and prevents hypertension associated with VEGF inhibition .
10764663	0	nitric_oxide	75,87	Endothelin-1	0,12	nitric oxide	Endothelin-1	MESH:D009569	24323(Tax:10116)	Chemical	Gene	deprivation|compound|START_ENTITY induced|nmod|deprivation cells|acl|induced apoptosis|nmod|cells inhibits|dobj|apoptosis inhibits|nsubj|END_ENTITY	Endothelin-1 inhibits apoptosis of vascular smooth muscle cells induced by nitric_oxide and serum deprivation via MAP kinase pathway .
11406476	0	nitric_oxide	94,106	Endothelin-1	0,12	nitric oxide	Endothelin-1	MESH:D009569	1906	Chemical	Gene	synthase|nmod|START_ENTITY synthase|nsubj|END_ENTITY	Endothelin-1 and nitric_oxide synthase in short rebound reaction to short exposure to inhaled nitric_oxide .
15743480	0	nitric_oxide	53,65	Endothelin-1	0,12	nitric oxide	Endothelin-1	MESH:D009569	1906	Chemical	Gene	production|amod|START_ENTITY triggers|dobj|production triggers|nsubj|END_ENTITY	Endothelin-1 in osteoarthritic chondrocytes triggers nitric_oxide production and upregulates collagenase production .
16741033	0	nitric_oxide	48,60	Endothelin-1	0,12	nitric oxide	Endothelin-1	MESH:D009569	1906	Chemical	Gene	efficacy|nmod|START_ENTITY influences|dobj|efficacy influences|nsubj|END_ENTITY	Endothelin-1 influences the efficacy of inhaled nitric_oxide in experimental acute_lung_injury .
17996868	0	nitric_oxide	74,86	Endothelin-1	0,12	nitric oxide	Endothelin-1	MESH:D009569	24323(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY activation|nmod|synthase causes|nmod|activation causes|nsubj|END_ENTITY	Endothelin-1 -LRB- ET-1 -RRB- causes death of retinal neurons through activation of nitric_oxide synthase -LRB- NOS -RRB- and production of superoxide anion .
19033447	0	nitric_oxide	72,84	Endothelin-1	0,12	nitric oxide	Endothelin-1	MESH:D009569	13614(Tax:10090)	Chemical	Gene	production|compound|START_ENTITY transport|nmod|production ascending|dobj|transport inhibits|xcomp|ascending inhibits|nsubj|END_ENTITY	Endothelin-1 inhibits thick ascending limb transport via Akt-stimulated nitric_oxide production .
19754268	0	nitric_oxide	21,33	Endothelin-1	0,12	nitric oxide	Endothelin-1	MESH:D009569	100294653(Tax:9940)	Chemical	Gene	START_ENTITY|nsubj|impairs impairs|amod|END_ENTITY	Endothelin-1 impairs nitric_oxide signaling in endothelial cells through a protein_kinase_Cdelta-dependent activation of STAT3 and decreased endothelial_nitric_oxide_synthase expression .
24392990	0	nitric_oxide	132,144	Endothelin-1	0,12	nitric oxide	Endothelin-1	MESH:D009569	24323(Tax:10116)	Chemical	Gene	synthase|compound|START_ENTITY translocation|nmod|synthase cells|nmod|translocation switch|nmod|cells induces|dobj|switch induces|nsubj|END_ENTITY	Endothelin-1 induces a glycolytic switch in pulmonary arterial endothelial cells via the mitochondrial translocation of endothelial nitric_oxide synthase .
8141330	0	nitric_oxide	74,86	Endothelin-1	0,12	nitric oxide	Endothelin-1	MESH:D009569	24323(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY production|dep|effect production|amod|END_ENTITY	Endothelin-1 production by rat inner medullary collecting duct : effect of nitric_oxide , cGMP , and immune cytokines .
8587249	0	nitric_oxide	69,81	Endothelin-1	0,12	nitric oxide	Endothelin-1	MESH:D009569	24323(Tax:10116)	Chemical	Gene	synthase|compound|START_ENTITY transcription|nmod|synthase inhibits|dobj|transcription inhibits|nsubj|END_ENTITY	Endothelin-1 inhibits cytokine-stimulated transcription of inducible nitric_oxide synthase in glomerular mesangial cells .
8958563	0	nitric_oxide	35,47	Endothelin-1	0,12	nitric oxide	Endothelin-1	MESH:D009569	24323(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY induction|nmod|synthase inhibits|dobj|induction inhibits|nsubj|END_ENTITY	Endothelin-1 inhibits induction of nitric_oxide synthase and GTP_cyclohydrolase_I in rat mesangial cells .
9039082	0	nitric_oxide	22,34	Endothelin-1	0,12	nitric oxide	Endothelin-1	MESH:D009569	24323(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY inhibits|dobj|synthesis inhibits|nsubj|END_ENTITY	Endothelin-1 inhibits nitric_oxide synthesis in vascular smooth muscle cells .
9227507	0	nitric_oxide	50,62	Endothelin-1	0,12	nitric oxide	Endothelin-1	MESH:D009569	24323(Tax:10116)	Chemical	Gene	synthase|compound|START_ENTITY expression|nmod|synthase inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Endothelin-1 inhibits the expression of inducible nitric_oxide synthase .
9643615	0	nitric_oxide	84,96	Endothelin-1	0,12	nitric oxide	Endothelin-1	MESH:D009569	1906	Chemical	Gene	fibres|nmod|START_ENTITY induces|nmod|fibres induces|nsubj|END_ENTITY	Endothelin-1 induces vasodilation in human skin by nociceptor fibres and release of nitric_oxide .
9892594	0	nitric_oxide	52,64	Endothelin-1	0,12	nitric oxide	Endothelin-1	MESH:D009569	1906	Chemical	Gene	synthesis|amod|START_ENTITY pressure|nmod|synthesis pressure|compound|END_ENTITY	Endothelin-1 and blood pressure after inhibition of nitric_oxide synthesis in human septic_shock .
1846538	0	nitric_oxide	58,70	Endothelin-3	0,12	nitric oxide	Endothelin-3	MESH:D009569	513753(Tax:9913)	Chemical	Gene	production|nmod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Endothelin-3 stimulates production of endothelium-derived nitric_oxide via phosphoinositide breakdown .
12509805	0	nitric_oxide	30,42	Erk	85,88	nitric oxide	Erk	MESH:D009569	24338(Tax:10116)	Chemical	Gene	expression|compound|START_ENTITY expression|dep|role role|nmod|protein protein|compound|END_ENTITY	Cytokine-stimulated inducible nitric_oxide synthase expression in astroglia : role of Erk mitogen-activated protein kinase and NF-kappaB .
10082505	0	nitric_oxide	25,37	Erythropoietin	0,14	nitric oxide	Erythropoietin	MESH:D009569	2056	Chemical	Gene	expression|amod|START_ENTITY depresses|dobj|expression depresses|nsubj|END_ENTITY	Erythropoietin depresses nitric_oxide synthase expression by human endothelial cells .
10803695	0	nitric_oxide	31,43	Erythropoietin	0,14	nitric oxide	Erythropoietin	MESH:D009569	24335(Tax:10116)	Chemical	Gene	system|amod|START_ENTITY affect|dobj|system affect|nsubj|END_ENTITY	Erythropoietin does not affect nitric_oxide system in rats with chronic_renal_failure .
10936493	0	nitric_oxide	71,83	Erythropoietin	0,14	nitric oxide	Erythropoietin	MESH:D009569	2056	Chemical	Gene	formation|amod|START_ENTITY inhibition|nmod|formation protects|nmod|inhibition protects|nsubj|END_ENTITY	Erythropoietin protects against brain_ischemic_injury by inhibition of nitric_oxide formation .
11163297	0	nitric_oxide	121,133	Erythropoietin	0,14	nitric oxide	Erythropoietin	MESH:D009569	13856(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY mice|nmod|production neuroprotection|dep|mice exerts|dobj|neuroprotection exerts|nsubj|END_ENTITY	Erythropoietin exerts neuroprotection in 1-methyl-4-phenyl-1 ,2,3,6 - tetrahydropyridine-treated C57/BL mice via increasing nitric_oxide production .
14508239	0	nitric_oxide	57,69	Erythropoietin	0,14	nitric oxide	Erythropoietin	MESH:D009569	24335(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY vascular|dobj|expression vascular|nsubj|administration administration|compound|END_ENTITY	Erythropoietin administration in vivo increases vascular nitric_oxide synthase expression .
14593244	0	nitric_oxide	92,104	Erythropoietin	0,14	nitric oxide	Erythropoietin	MESH:D009569	24335(Tax:10116)	Chemical	Gene	formation|compound|START_ENTITY protects|nmod|formation protects|nsubj|END_ENTITY	Erythropoietin protects against necrotizing_enterocolitis of newborn rats by the inhibiting nitric_oxide formation .
17049112	0	nitric_oxide	57,69	Erythropoietin	0,14	nitric oxide	Erythropoietin	MESH:D009569	2056	Chemical	Gene	role|nmod|START_ENTITY protection|dep|role protection|compound|END_ENTITY	Erythropoietin and cerebral vascular protection : role of nitric_oxide .
18838945	0	nitric_oxide	88,100	Erythropoietin	0,14	nitric oxide	Erythropoietin	MESH:D009569	2056	Chemical	Gene	synthase|amod|START_ENTITY modulation|nmod|synthase enhances|nmod|modulation enhances|nsubj|END_ENTITY	Erythropoietin enhances oxygenation in critically perfused tissue through modulation of nitric_oxide synthase .
19237290	0	nitric_oxide	101,113	Erythropoietin	0,14	nitric oxide	Erythropoietin	MESH:D009569	24335(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY enhancing|dobj|production protects|advcl|enhancing protects|nsubj|END_ENTITY	Erythropoietin protects from reperfusion-induced myocardial_injury by enhancing coronary endothelial nitric_oxide production .
19515903	0	nitric_oxide	25,37	Erythropoietin	0,14	nitric oxide	Erythropoietin	MESH:D009569	13856(Tax:10090)	Chemical	Gene	synthase|amod|START_ENTITY activates|dobj|synthase activates|nsubj|END_ENTITY	Erythropoietin activates nitric_oxide synthase in murine erythrocytes .
20926979	0	nitric_oxide	36,48	Erythropoietin	0,14	nitric oxide	Erythropoietin	MESH:D009569	13856(Tax:10090)	Chemical	Gene	requires|dobj|START_ENTITY requires|nsubj|END_ENTITY	Erythropoietin requires endothelial nitric_oxide synthase to counteract TNF - -LSB- alpha -RSB- - induced microcirculatory_dysfunction in murine striated muscle .
21108937	0	nitric_oxide	24,36	Erythropoietin	0,14	nitric oxide	Erythropoietin	MESH:D009569	2056	Chemical	Gene	neuronal_death|amod|START_ENTITY prevents|dobj|neuronal_death prevents|nsubj|END_ENTITY	Erythropoietin prevents nitric_oxide and cathepsin-mediated neuronal_death in focal brain_ischemia .
10586030	0	nitric_oxide	169,181	Extracellular_signal-related_kinase	0,35	nitric oxide	Extracellular signal-related kinase	MESH:D009569	5594	Chemical	Gene	regulate|ccomp|START_ENTITY regulate|nsubj|END_ENTITY	Extracellular_signal-related_kinase -LRB- ERK -RRB- and p38 mitogen-activated protein -LRB- MAP -RRB- kinases differentially regulate the lipopolysaccharide-mediated induction of inducible nitric_oxide synthase and IL-12 in macrophages : Leishmania phosphoglycans subvert macrophage IL-12 production by targeting ERK MAP kinase .
10320729	0	nitric_oxide	39,51	Fos	69,72	nitric oxide	Fos	MESH:D009569	314322(Tax:10116)	Chemical	Gene	donor|amod|START_ENTITY injection|nmod|donor attenuates|nsubj|injection attenuates|dobj|expression expression|compound|END_ENTITY	Intracerebroventricular injection of a nitric_oxide donor attenuates Fos expression in the paraventricular and supraoptic nuclei of lactating rats .
10569236	0	nitric_oxide	40,52	Fos	87,90	nitric oxide	Fos	MESH:D009569	314322(Tax:10116)	Chemical	Gene	manipulation|nmod|START_ENTITY manipulation|parataxis|alters alters|dobj|expression expression|compound|END_ENTITY	Pharmacological manipulation of central nitric_oxide / guanylate cyclase activity alters Fos expression by rat hypothalamic vasopressinergic neurons during acute_glucose_deprivation .
10683575	0	nitric_oxide	39,51	Fos	0,3	nitric oxide	Fos	MESH:D009569	314322(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY induced|nmod|release induced|nsubjpass|expression expression|compound|END_ENTITY	Fos expression is induced by increased nitric_oxide release in rat spinal cord dorsal horn .
11070199	0	nitric_oxide	54,66	Fos	0,3	nitric oxide	Fos	MESH:D009569	314322(Tax:10116)	Chemical	Gene	synthase|compound|START_ENTITY immunoreactive|nmod|synthase immunoreactive|nsubj|expression expression|compound|END_ENTITY	Fos expression in neurons immunoreactive for neuronal nitric_oxide synthase in the rat paraventricular nucleus after intraperitoneal injection of interleukin-1_beta .
12910709	0	nitric_oxide	44,56	Fos	11,14	nitric oxide	Fos	MESH:D009569	314322(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Effect Effect|nmod|expression expression|compound|END_ENTITY	-LSB- Effect of Fos expression induced by spinal nitric_oxide on the nociception of formalin in rats -RSB- .
15197473	0	nitric_oxide	44,56	Fos	89,92	nitric oxide	Fos	MESH:D009569	14281(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY inactivation|nmod|synthase affects|nsubj|inactivation affects|dobj|expression expression|compound|END_ENTITY	Genetic functional inactivation of neuronal nitric_oxide synthase affects stress-related Fos expression in specific brain regions .
23634870	4	nitric_oxide	749,761	Fos	678,681	nitric oxide	VIP	MESH:D009569	117064(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY activity|appos|synthase marker|nmod|activity gene|nmod|marker immunohistochemistry|acl:relcl|gene immunohistochemistry|nmod|END_ENTITY	The esophagus was processed for immunohistochemistry for Fos that was an immediate-early gene as a marker of neuronal activity , nitric_oxide synthase -LRB- NOS -RRB- , vasoactive intestinal polypeptide -LRB- VIP -RRB- and choline acetyltransferase -LRB- ChAT -RRB- .
8603591	0	nitric_oxide	60,72	Fos	22,25	nitric oxide	Fos	MESH:D009569	314322(Tax:10116)	Chemical	Gene	synthase|compound|START_ENTITY regulate|dobj|synthase regulate|nsubj|END_ENTITY	Interleukin 1-induced Fos and Jun do not regulate inducible nitric_oxide synthase in rat islets of Langerhans and RINm5F cells .
9132683	0	nitric_oxide	13,25	Fos	95,98	nitric oxide	Fos	MESH:D009569	314322(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY blocker|nmod|synthase attenuates|nsubj|blocker attenuates|dobj|expression expression|compound|END_ENTITY	A blocker of nitric_oxide synthase , NG-nitro-L-arginine_methyl_ester , attenuates light-induced Fos protein expression in rat suprachiasmatic nucleus .
20083653	0	nitric_oxide	76,88	Foxp3	55,60	nitric oxide	Foxp3	MESH:D009569	20371(Tax:10090)	Chemical	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	Myelin_basic_protein priming reduces the expression of Foxp3 in T cells via nitric_oxide .
1330492	0	nitric_oxide	15,27	GH	47,49	nitric oxide	GH	MESH:D009569	81668(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|growth_hormone growth_hormone|appos|END_ENTITY	Involvement of nitric_oxide in growth_hormone -LRB- GH -RRB- - releasing hormone-induced GH secretion in rat pituitary cells .
11595753	0	nitric_oxide	93,105	GLUT3	34,39	nitric oxide	GLUT3	MESH:D009569	25551(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY Expression|dep|role Expression|nmod|END_ENTITY	Expression of glucose transporter GLUT3 by endotoxin in cultured rat astrocytes : the role of nitric_oxide .
19447893	0	nitric_oxide	48,60	GTP_cyclohydrolase_I	0,20	nitric oxide	GTP cyclohydrolase I	MESH:D009569	2643	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|compound|END_ENTITY	GTP_cyclohydrolase_I expression is regulated by nitric_oxide : role of cyclic_AMP .
21914816	0	nitric_oxide	46,58	Glutamine_synthetase	0,20	nitric oxide	Glutamine synthetase	MESH:D009569	11405318	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Glutamine_synthetase is a molecular target of nitric_oxide in root nodules of Medicago_truncatula and is regulated by tyrosine nitration .
9808267	0	nitric_oxide	57,69	Granulocyte-colony_stimulating_factor	0,37	nitric oxide	Granulocyte-colony stimulating factor	MESH:D009569	1440	Chemical	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Granulocyte-colony_stimulating_factor inhibits inducible nitric_oxide synthase gene expression in pulmonary epithelial cells in vitro .
10906155	0	nitric_oxide	35,47	Growth_hormone	0,14	nitric oxide	Growth hormone	MESH:D009569	14599(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY inducible|dobj|expression inducible|nsubj|increases increases|amod|END_ENTITY	Growth_hormone increases inducible nitric_oxide synthase expression in mesangial cells .
16937444	0	nitric_oxide	91,103	Growth_hormone	0,14	nitric oxide	Growth hormone	MESH:D009569	2688	Chemical	Gene	pathway|amod|START_ENTITY modulation|nmod|pathway regulates|nmod|modulation regulates|nsubj|END_ENTITY	Growth_hormone regulates intestinal ion transport through a modulation of the constitutive nitric_oxide synthase-nitric_oxide-cAMP pathway .
17726074	0	nitric_oxide	54,66	Growth_hormone	0,14	nitric oxide	Growth hormone	MESH:D009569	2688	Chemical	Gene	bioavailability|compound|START_ENTITY markers|nmod|bioavailability improves|dobj|markers improves|nsubj|treatment treatment|amod|END_ENTITY	Growth_hormone treatment improves markers of systemic nitric_oxide bioavailability via insulin-like growth factor-I .
9783982	0	nitric_oxide	40,52	Growth_hormone	0,14	nitric oxide	Growth hormone	MESH:D009569	81668(Tax:10116)	Chemical	Gene	nerves|amod|START_ENTITY regeneration|nmod|nerves enhances|dobj|regeneration enhances|nsubj|END_ENTITY	Growth_hormone enhances regeneration of nitric_oxide synthase-containing penile nerves after cavernous nerve neurotomy in rats .
15901372	1	nitric_oxide	71,83	HIF-1	61,66	nitric oxide	HIF-1	MESH:D009569	3091	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of hypoxia-inducible_factor_1 -LRB- HIF-1 -RRB- by nitric_oxide in oral_squamous_cell_carcinoma .
11159530	0	nitric_oxide	50,62	HIF-1alpha	16,26	nitric oxide	HIF-1alpha	MESH:D009569	396696(Tax:9823)	Chemical	Gene	Accumulation|nmod|START_ENTITY Accumulation|nmod|END_ENTITY	Accumulation of HIF-1alpha under the influence of nitric_oxide .
12055086	0	nitric_oxide	8,20	HIF-1alpha	42,52	nitric oxide	HIF-1alpha	MESH:D009569	3091	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|regulation regulation|nmod|expression expression|compound|END_ENTITY	Role of nitric_oxide in the regulation of HIF-1alpha expression during hypoxia .
16920974	0	nitric_oxide	26,38	HMGB1	57,62	nitric oxide	HMGB1	MESH:D009569	15289(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	The role of IFN-alpha and nitric_oxide in the release of HMGB1 by RAW 264.7 cells stimulated with polyinosinic-polycytidylic_acid or lipopolysaccharide .
23223086	0	nitric_oxide	33,45	Haptoglobin	0,11	nitric oxide	Haptoglobin	MESH:D009569	3240	Chemical	Gene	bioavailability|amod|START_ENTITY affects|dobj|bioavailability affects|nsubj|polymorphism polymorphism|compound|END_ENTITY	Haptoglobin polymorphism affects nitric_oxide bioavailability in preeclampsia .
17337508	0	nitric_oxide	44,56	Heat_shock_protein_90	0,21	nitric oxide	Heat shock protein 90	MESH:D009569	3320	Chemical	Gene	activity|compound|START_ENTITY modulates|dobj|activity modulates|nsubj|END_ENTITY	Heat_shock_protein_90 modulates endothelial nitric_oxide synthase activity and vascular reactivity in the newborn piglet_pulmonary_circulation .
11287117	0	nitric_oxide	30,42	Heme_oxygenase-1	0,16	nitric oxide	Heme oxygenase-1	MESH:D009569	3162	Chemical	Gene	macrophages|amod|START_ENTITY induction|nmod|macrophages induction|amod|END_ENTITY	Heme_oxygenase-1 induction by nitric_oxide in RAW 264.7 macrophages is upregulated by a cyclo-oxygenase-2 inhibitor .
12134106	0	nitric_oxide	50,62	Heme_oxygenase-1	0,16	nitric oxide	Heme oxygenase-1	MESH:D009569	24451(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|transfer transfer|amod|END_ENTITY	Heme_oxygenase-1 gene transfer inhibits inducible nitric_oxide synthase expression and protects genetically fat Zucker rat livers from ischemia-reperfusion injury .
12832044	0	nitric_oxide	41,53	Heme_oxygenase-1	0,16	nitric oxide	Heme oxygenase-1	MESH:D009569	3162	Chemical	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Heme_oxygenase-1 induction by endogenous nitric_oxide : influence of intracellular glutathione .
15591777	0	nitric_oxide	54,66	Heme_oxygenase-1	0,16	nitric oxide	Heme oxygenase-1	MESH:D009569	24451(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY attenuates|dobj|expression attenuates|nsubj|END_ENTITY	Heme_oxygenase-1 attenuates interleukin-1beta-induced nitric_oxide synthase expression in vascular smooth muscle cells .
15834587	0	nitric_oxide	51,63	Heme_oxygenase-1	0,16	nitric oxide	Heme oxygenase-1	MESH:D009569	3162	Chemical	Gene	effects|nmod|START_ENTITY accelerates|dobj|effects accelerates|nsubj|END_ENTITY	Heme_oxygenase-1 accelerates protumoral effects of nitric_oxide in cancer cells .
17890422	0	nitric_oxide	68,80	Heme_oxygenase-1	0,16	nitric oxide	Heme oxygenase-1	MESH:D009569	24451(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY ischemic_renal_failure|dep|role improves|dobj|ischemic_renal_failure improves|nsubj|induction induction|amod|END_ENTITY	Heme_oxygenase-1 induction improves ischemic_renal_failure : role of nitric_oxide and peroxynitrite .
17920533	0	nitric_oxide	108,120	Heme_oxygenase-1	0,16	nitric oxide	Heme oxygenase-1	MESH:D009569	3162	Chemical	Gene	production|amod|START_ENTITY cells|nsubj|production inhibits|xcomp|cells inhibits|nsubj|induction induction|amod|END_ENTITY	Heme_oxygenase-1 induction by -LRB- S -RRB- - enantiomer of YS-51 -LRB- YS-51S -RRB- , a synthetic isoquinoline_alkaloid , inhibits nitric_oxide production and nuclear factor-kappaB translocation in ROS 17/2 .8 cells activated with inflammatory stimulants .
20819234	0	nitric_oxide	76,88	Heme_oxygenase-1	0,16	nitric oxide	Heme oxygenase-1	MESH:D009569	3162	Chemical	Gene	G|compound|START_ENTITY death|nmod|G stem|dobj|death plays|ccomp|stem plays|nsubj|END_ENTITY	Heme_oxygenase-1 plays a pro-life role in experimental brain stem death via nitric_oxide synthase I/protein kinase G signaling at rostral ventrolateral medulla .
21646819	0	nitric_oxide	73,85	Heme_oxygenase-1	0,16	nitric oxide	Heme oxygenase-1	MESH:D009569	24451(Tax:10116)	Chemical	Gene	system|amod|START_ENTITY operative|nsubj|system attenuate|advcl|operative fails|xcomp|attenuate fails|nsubj|overexpression overexpression|amod|END_ENTITY	Heme_oxygenase-1 overexpression fails to attenuate hypertension when the nitric_oxide synthase system is not fully operative .
23090695	0	nitric_oxide	32,44	Heme_oxygenase-1	0,16	nitric oxide	Heme oxygenase-1	MESH:D009569	100682424	Chemical	Gene	expression|amod|START_ENTITY involved|nmod|expression involved|nsubjpass|END_ENTITY	Heme_oxygenase-1 is involved in nitric_oxide - and cGMP-induced a-Amy2 / 54 gene expression in GA-treated wheat aleurone layers .
10644573	0	nitric_oxide	73,85	Heme_oxygenase-2	0,16	nitric oxide	Heme oxygenase-2	MESH:D009569	3163	Chemical	Gene	synthase|compound|START_ENTITY colocalization|nmod|synthase distribution|dep|colocalization distribution|amod|END_ENTITY	Heme_oxygenase-2 distribution in anorectum : colocalization with neuronal nitric_oxide synthase .
11890738	0	nitric_oxide	114,126	Heparin-binding_EGF-like_growth_factor	0,38	nitric oxide	Heparin-binding EGF-like growth factor	MESH:D009569	1839	Chemical	Gene	production|amod|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	Heparin-binding_EGF-like_growth_factor down regulates proinflammatory cytokine-induced nitric_oxide and inducible nitric_oxide synthase production in intestinal epithelial cells .
11890738	0	nitric_oxide	87,99	Heparin-binding_EGF-like_growth_factor	0,38	nitric oxide	Heparin-binding EGF-like growth factor	MESH:D009569	1839	Chemical	Gene	production|amod|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	Heparin-binding_EGF-like_growth_factor down regulates proinflammatory cytokine-induced nitric_oxide and inducible nitric_oxide synthase production in intestinal epithelial cells .
10498850	0	nitric_oxide	87,99	Hepatocyte_growth_factor	0,24	nitric oxide	Hepatocyte growth factor	MESH:D009569	3082	Chemical	Gene	role|nmod|START_ENTITY motility|dep|role regulates|dobj|motility regulates|nsubj|END_ENTITY	Hepatocyte_growth_factor regulates human trophoblast motility and invasion : a role for nitric_oxide .
15824471	0	nitric_oxide	36,48	Hepatocyte_growth_factor	0,24	nitric oxide	Hepatocyte growth factor	MESH:D009569	282879(Tax:9913)	Chemical	Gene	production|amod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Hepatocyte_growth_factor stimulates nitric_oxide production through endothelial nitric_oxide synthase activation by the phosphoinositide 3-kinase/Akt pathway and possibly by mitogen-activated protein kinase kinase in vascular endothelial cells .
15824471	0	nitric_oxide	80,92	Hepatocyte_growth_factor	0,24	nitric oxide	Hepatocyte growth factor	MESH:D009569	282879(Tax:9913)	Chemical	Gene	activation|amod|START_ENTITY stimulates|nmod|activation stimulates|nsubj|END_ENTITY	Hepatocyte_growth_factor stimulates nitric_oxide production through endothelial nitric_oxide synthase activation by the phosphoinositide 3-kinase/Akt pathway and possibly by mitogen-activated protein kinase kinase in vascular endothelial cells .
26386740	0	nitric_oxide	148,160	Hmox-1	178,184	nitric oxide	Hmox-1	MESH:D009569	3162	Chemical	Gene	production|nmod|START_ENTITY production|nmod|END_ENTITY	Chlorogenic_acid improves ex vivo vessel function and protects endothelial cells against HOCl-induced oxidative damage , via increased production of nitric_oxide and induction of Hmox-1 .
9580552	0	nitric_oxide	34,46	Hsp90	59,64	nitric oxide	Hsp90	MESH:D009569	3320	Chemical	Gene	activation|nmod|START_ENTITY synthase|nsubj|activation synthase|nmod|END_ENTITY	Dynamic activation of endothelial nitric_oxide synthase by Hsp90 .
22004293	0	nitric_oxide	28,40	Hsp90b	0,6	nitric oxide	Hsp90b	MESH:D009569	3326	Chemical	Gene	START_ENTITY|nsubj|modulates modulates|amod|END_ENTITY	Hsp90b inhibition modulates nitric_oxide production and nitric_oxide-induced apoptosis in human chondrocytes .
17998069	0	nitric_oxide	53,65	Hypoxia-inducible_factor-1alpha	0,31	nitric oxide	Hypoxia-inducible factor-1alpha	MESH:D009569	3091	Chemical	Gene	control|nmod|START_ENTITY END_ENTITY|nmod|control	Hypoxia-inducible_factor-1alpha under the control of nitric_oxide .
16234848	0	nitric_oxide	42,54	Hypoxia_inducible_factor-1	0,26	nitric oxide	Hypoxia inducible factor-1	MESH:D009569	3091	Chemical	Gene	regulation|nmod|START_ENTITY END_ENTITY|dep|regulation	Hypoxia_inducible_factor-1 : regulation by nitric_oxide in posthypoxic microvascular endothelium .
14614712	0	nitric_oxide	15,27	ICAM-1	74,80	nitric oxide	ICAM-1	MESH:D009569	25464(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|END_ENTITY	The effects of nitric_oxide on the expression of cell adhesion molecules -LRB- ICAM-1 , UEA-1 , and tenascin -RRB- in rats with unilateral testicular torsion .
10898490	0	nitric_oxide	94,106	IFN-beta	43,51	nitric oxide	IFN-beta	MESH:D009569	15977(Tax:10090)	Chemical	Gene	gene|amod|START_ENTITY transcription|nmod|gene transcription|amod|END_ENTITY	Prolonged exposure of mouse macrophages to IFN-beta suppresses transcription of the inducible nitric_oxide synthase gene : altered availability of transcription factor Stat1alpha .
11331036	0	nitric_oxide	36,48	IFN-beta	14,22	nitric oxide	IFN-beta	MESH:D009569	15977(Tax:10090)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation by IFN-beta of inducible nitric_oxide synthase and interleukin-12 / p40 in murine macrophages cultured in the presence of Chlamydia_pneumoniae antigens .
15611612	0	nitric_oxide	50,62	IFN-beta	88,96	nitric oxide	IFN-beta	MESH:D009569	15977(Tax:10090)	Chemical	Gene	production|compound|START_ENTITY inhibits|dobj|production inhibits|advcl|preventing preventing|dobj|production production|amod|END_ENTITY	2-aminopurine inhibits lipopolysaccharide-induced nitric_oxide production by preventing IFN-beta production .
9815626	0	nitric_oxide	140,152	IFN-beta	108,116	nitric oxide	IFN-beta	MESH:D009569	15977(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY Abrogation|dep|role Abrogation|nmod|transfection transfection|nmod|gene gene|amod|END_ENTITY	Abrogation of tumorigenicity and metastasis of murine and human tumor cells by transfection with the murine IFN-beta gene : possible role of nitric_oxide .
16507487	0	nitric_oxide	25,37	IFN-gamma	0,9	nitric oxide	IFN-gamma	MESH:D009569	15978(Tax:10090)	Chemical	Gene	regulation|nmod|START_ENTITY END_ENTITY|dep|regulation	IFN-gamma : regulation of nitric_oxide in the P. _ aeruginosa-infected_cornea .
21744329	0	nitric_oxide	28,40	IFN-gamma	85,94	nitric oxide	IFN-gamma	MESH:D009569	3458	Chemical	Gene	START_ENTITY|appos|IL-13 IL-13|dep|END_ENTITY	Assessment of the levels of nitric_oxide -LRB- NO -RRB- and cytokines -LRB- IL-5 , IL-6 , IL-13 , TNF , IFN-gamma -RRB- in giardiosis .
7541825	0	nitric_oxide	75,87	IFN-gamma	33,42	nitric oxide	IFN-gamma	MESH:D009569	15978(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Exogenous nitric_oxide regulates IFN-gamma plus lipopolysaccharide-induced nitric_oxide synthase expression in mouse macrophages .
9301524	0	nitric_oxide	58,70	IFN-gamma	27,36	nitric oxide	IFN-gamma	MESH:D009569	3458	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|END_ENTITY	Differential regulation of IFN-gamma , IL-10 and inducible nitric_oxide synthase in human T cells by cyclic_AMP-dependent signal transduction pathway .
9512901	0	nitric_oxide	69,81	IFN-gamma	23,32	nitric oxide	IFN-gamma	MESH:D009569	15978(Tax:10090)	Chemical	Gene	release|compound|START_ENTITY role|nmod|release role|nmod|END_ENTITY	The role of endogenous IFN-gamma , TNF-alpha and IL-10 in LPS-induced nitric_oxide release in a mouse model .
9541578	0	nitric_oxide	73,85	IFN-gamma	132,141	nitric oxide	IFN-gamma	MESH:D009569	15978(Tax:10090)	Chemical	Gene	START_ENTITY|acl|generated generated|nmod|END_ENTITY	IFN-gamma-induced TNF-alpha is a prerequisite for in vitro production of nitric_oxide generated in murine peritoneal macrophages by IFN-gamma .
9616876	0	nitric_oxide	74,86	IFN_gamma	134,143	nitric oxide	IFN gamma	MESH:D009569	15978(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY inhibits|dobj|production inhibits|nmod|macrophages macrophages|acl|stimulated stimulated|nmod|END_ENTITY	Docosahexaenoic_acid , a constituent of fetal and neonatal serum , inhibits nitric_oxide production by murine macrophages stimulated by IFN_gamma plus LPS , or by IFN_gamma plus Listeria_monocytogenes .
10553803	0	nitric_oxide	55,67	IGF-I	0,5	nitric oxide	IGF-I	MESH:D009569	24482(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY regeneration|nmod|synthase role|nmod|regeneration have|dobj|role have|nsubj|END_ENTITY	IGF-I and TGF-beta2 have a key role on regeneration of nitric_oxide synthase -LRB- NOS -RRB- - containing nerves after cavernous neurotomy in rats .
10868937	0	nitric_oxide	37,49	IGF-I	21,26	nitric oxide	IGF-I	MESH:D009569	24482(Tax:10116)	Chemical	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Inhibitory effect of IGF-I on type 2 nitric_oxide synthase expression in Ins-1 cells and protection against activation-dependent apoptosis : involvement of phosphatidylinositol 3-kinase .
9575890	0	nitric_oxide	44,56	IGF-I	0,5	nitric oxide	IGF-I	MESH:D009569	3479	Chemical	Gene	amplify|dobj|START_ENTITY amplify|nsubj|END_ENTITY	IGF-I and insulin amplify IL-1_beta-induced nitric_oxide and prostaglandin biosynthesis .
8952702	0	nitric_oxide	40,52	IL-1	27,31	nitric oxide	IL-1	MESH:D009569	3552	Chemical	Gene	production|amod|START_ENTITY induced|dobj|production END_ENTITY|acl|induced	Cytostasis is required for IL-1 induced nitric_oxide production in transformed hamster fibroblasts .
11168556	0	nitric_oxide	62,74	IL-10	124,129	nitric oxide	IL-10	MESH:D009569	3586	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	LPS/IFN-gamma cytotoxicity in oligodendroglial cells : role of nitric_oxide and protection by the anti-inflammatory cytokine IL-10 .
12946433	0	nitric_oxide	87,99	IL-10	55,60	nitric oxide	IL-10	MESH:D009569	16153(Tax:10090)	Chemical	Gene	synthesis|amod|START_ENTITY stimulation|nmod|synthesis stimulation|nmod|release release|compound|END_ENTITY	Anti-inflammatory effects of annexin-1 : stimulation of IL-10 release and inhibition of nitric_oxide synthesis .
1371674	0	nitric_oxide	49,61	IL-10	16,21	nitric oxide	IL-10	MESH:D009569	16153(Tax:10090)	Chemical	Gene	synthase|amod|START_ENTITY induction|nmod|synthase inhibits|dobj|induction inhibits|nsubj|Interleukin-10 Interleukin-10|appos|END_ENTITY	Interleukin-10 -LRB- IL-10 -RRB- inhibits the induction of nitric_oxide synthase by interferon-gamma in murine macrophages .
14758059	0	nitric_oxide	15,27	IL-10	0,5	nitric oxide	IL-10	MESH:D009569	16153(Tax:10090)	Chemical	Gene	synthesis|amod|START_ENTITY inhibits|dobj|synthesis inhibits|nsubj|END_ENTITY	IL-10 inhibits nitric_oxide synthesis in murine uterus .
15577225	0	nitric_oxide	118,130	IL-10	162,167	nitric oxide	IL-10	MESH:D009569	16153(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Protective effect of protocatechuic_acid_isopropyl_ester against murine models of sepsis : inhibition of TNF-alpha and nitric_oxide production and augmentation of IL-10 .
15618456	0	nitric_oxide	9,21	IL-10	93,98	nitric oxide	IL-10	MESH:D009569	16153(Tax:10090)	Chemical	Gene	production|compound|START_ENTITY associated|nsubj|production associated|nmod|hyporesponsiveness hyporesponsiveness|nmod|absence absence|nmod|END_ENTITY	Enhanced nitric_oxide production associated with airway hyporesponsiveness in the absence of IL-10 .
16002724	0	nitric_oxide	15,27	IL-10	95,100	nitric oxide	IL-10	MESH:D009569	16153(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY Alterations|nmod|production Alterations|nmod|absence absence|nmod|END_ENTITY	Alterations in nitric_oxide and cytokine production with airway inflammation in the absence of IL-10 .
17673149	0	nitric_oxide	23,35	IL-10	55,60	nitric oxide	IL-10	MESH:D009569	16153(Tax:10090)	Chemical	Gene	production|compound|START_ENTITY limits|dobj|production limits|nmod|macrophages macrophages|amod|END_ENTITY	VIP limits LPS-induced nitric_oxide production through IL-10 in NOD mice macrophages .
18655171	0	nitric_oxide	40,52	IL-10	111,116	nitric oxide	IL-10	MESH:D009569	3586	Chemical	Gene	biosynthesis|amod|START_ENTITY induce|dobj|biosynthesis synergizes|acl|induce synthase|nsubj|synergizes synthase|dobj|END_ENTITY	IFN-gamma synergizes with LPS to induce nitric_oxide biosynthesis through glycogen synthase kinase-3-inhibited IL-10 .
19124754	0	nitric_oxide	28,40	IL-10	0,5	nitric oxide	IL-10	MESH:D009569	16153(Tax:10090)	Chemical	Gene	dampens|ccomp|START_ENTITY dampens|nsubj|END_ENTITY	IL-10 dampens TNF/inducible nitric_oxide synthase-producing dendritic cell-mediated pathogenicity during parasitic_infection .
7530004	0	nitric_oxide	37,49	IL-10	67,72	nitric oxide	IL-10	MESH:D009569	16153(Tax:10090)	Chemical	Gene	synthesis|amod|START_ENTITY suppressors|nmod|synthesis induction|nmod|suppressors induction|appos|IL-4 IL-4|dep|END_ENTITY	Arginase induction by suppressors of nitric_oxide synthesis -LRB- IL-4 , IL-10 and PGE2 -RRB- in murine bone-marrow-derived macrophages .
7908304	0	nitric_oxide	37,49	IL-10	18,23	nitric oxide	IL-10	MESH:D009569	16153(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Neutralization Neutralization|nmod|up-regulates up-regulates|compound|END_ENTITY	Neutralization of IL-10 up-regulates nitric_oxide production and protects susceptible mice from challenge with Candida_albicans .
9379051	0	nitric_oxide	39,51	IL-13	63,68	nitric oxide	IL-13	MESH:D009569	16163(Tax:10090)	Chemical	Gene	release|compound|START_ENTITY release|nmod|END_ENTITY	Mechanism of suppression of macrophage nitric_oxide release by IL-13 : influence of the macrophage population .
20102341	0	nitric_oxide	41,53	IL-17	19,24	nitric oxide	IL-17	MESH:D009569	16171(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Combined effect of IL-17 and blockade of nitric_oxide biosynthesis on haematopoiesis in mice .
22219320	0	nitric_oxide	25,37	IL-17	61,66	nitric oxide	IL-17	MESH:D009569	3605	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Induction of endothelial nitric_oxide synthase expression by IL-17 in human vascular endothelial cells : implications for vascular remodeling in transplant vasculopathy .
10189071	0	nitric_oxide	90,102	IL-1alpha	10,19	nitric oxide	IL-1alpha	MESH:D009569	24493(Tax:10116)	Chemical	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|Effect Effect|nmod|END_ENTITY	Effect of IL-1alpha on prostaglandin synthesis of oestrogenized rat uterus is mediated by nitric_oxide .
21035557	0	nitric_oxide	42,54	IL-1b	26,31	nitric oxide	IL-1b	MESH:D009569	3553	Chemical	Gene	synthase|amod|START_ENTITY synthase|amod|inducible inducible|amod|END_ENTITY	Selenomethionine inhibits IL-1b inducible nitric_oxide synthase -LRB- iNOS -RRB- and cyclooxygenase_2 -LRB- COX2 -RRB- expression in primary human chondrocytes .
24425765	0	nitric_oxide	137,149	IL-1b	0,5	nitric oxide	IL-1b	MESH:D009569	24494(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY oxidase|acl|inhibition hampers|nmod|oxidase hampers|nsubj|END_ENTITY	IL-1b hampers glucose-stimulated insulin secretion in Cohen diabetic rat islets through mitochondrial cytochrome c oxidase inhibition by nitric_oxide .
11006448	0	nitric_oxide	24,36	IL-1beta	87,95	nitric oxide	IL-1beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	Expression|nmod|START_ENTITY synthase|nsubj|Expression synthase|nmod|END_ENTITY	Expression of inducible nitric_oxide synthase -LRB- iNOS -RRB- in middle_ear_epithelial_cells by IL-1beta and TNF-alpha .
15115662	0	nitric_oxide	96,108	IL-1beta	55,63	nitric oxide	IL-1beta	MESH:D009569	3553	Chemical	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	JNK signaling involved in the effects of cyclic_AMP on IL-1beta plus IFNgamma-induced inducible nitric_oxide synthase expression in hepatocytes .
9107570	0	nitric_oxide	33,45	IL-2	14,18	nitric oxide	IL-2	MESH:D009569	3558	Chemical	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	Inhibition of IL-2 production by nitric_oxide : a novel self-regulatory mechanism for Th1 cell proliferation .
12592345	0	nitric_oxide	59,71	IL-4	0,4	nitric oxide	IL-4	MESH:D009569	3565	Chemical	Gene	synthase|compound|START_ENTITY expression|nmod|synthase regulate|dobj|expression regulate|nsubj|gamma gamma|compound|END_ENTITY	IL-4 and interferon gamma regulate expression of inducible nitric_oxide synthase in chronic_lymphocytic_leukemia cells .
7530004	0	nitric_oxide	37,49	IL-4	61,65	nitric oxide	IL-4	MESH:D009569	16189(Tax:10090)	Chemical	Gene	synthesis|amod|START_ENTITY suppressors|nmod|synthesis induction|nmod|suppressors induction|appos|END_ENTITY	Arginase induction by suppressors of nitric_oxide synthesis -LRB- IL-4 , IL-10 and PGE2 -RRB- in murine bone-marrow-derived macrophages .
9305732	0	nitric_oxide	60,72	IL-4	10,14	nitric oxide	IL-4	MESH:D009569	16189(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of IL-4 and IL-13 on IFN-gamma-induced production of nitric_oxide in mouse macrophages infected with herpes_simplex_virus_type_2 .
9328118	0	nitric_oxide	75,87	IL-4	24,28	nitric oxide	IL-4	MESH:D009569	280824(Tax:9913)	Chemical	Gene	expression|amod|START_ENTITY effects|nmod|expression effects|nmod|END_ENTITY	Antagonistic effects of IL-4 and interferon-gamma -LRB- IFN-gamma -RRB- on inducible nitric_oxide synthase expression in bovine macrophages exposed to gram-positive bacteria .
17189827	0	nitric_oxide	67,79	IL-6	14,18	nitric oxide	IL-6	MESH:D009569	16193(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY expression|nmod|synthase signaling|nmod|expression role|parataxis|signaling role|nmod|END_ENTITY	Novel role of IL-6 / SIL-6R signaling in the expression of inducible nitric_oxide synthase -LRB- iNOS -RRB- in murine B16 , metastatic melanoma clone F10 .9 , cells .
21744329	0	nitric_oxide	28,40	IL-6	67,71	nitric oxide	IL-6	MESH:D009569	3569	Chemical	Gene	START_ENTITY|appos|IL-13 IL-13|dep|END_ENTITY	Assessment of the levels of nitric_oxide -LRB- NO -RRB- and cytokines -LRB- IL-5 , IL-6 , IL-13 , TNF , IFN-gamma -RRB- in giardiosis .
7578978	0	nitric_oxide	48,60	IL-6	18,22	nitric oxide	IL-6	MESH:D009569	16193(Tax:10090)	Chemical	Gene	stimulation|compound|START_ENTITY release|nmod|stimulation release|nsubj|modulation modulation|nmod|END_ENTITY	The modulation of IL-6 and TNF-alpha release by nitric_oxide following stimulation of J774 cells with LPS and IFN-gamma .
9722036	0	nitric_oxide	34,46	IL-6	78,82	nitric oxide	IL-6	MESH:D009569	3569	Chemical	Gene	synthesis|amod|START_ENTITY inhibitor|nmod|synthesis L-NAME|appos|inhibitor Effect|nmod|L-NAME Effect|nmod|levels levels|nmod|END_ENTITY	Effect of L-NAME , an inhibitor of nitric_oxide synthesis , on plasma levels of IL-6 , IL-8 , TNF_alpha and nitrite/nitrate in human septic_shock .
18023202	0	nitric_oxide	32,44	IL-8	0,4	nitric oxide	IL-8	MESH:D009569	3576	Chemical	Gene	cells|amod|START_ENTITY imbalances|nmod|cells induces|dobj|imbalances induces|nsubj|END_ENTITY	IL-8 induces imbalances between nitric_oxide and endothelin-1 , and also between plasminogen_activator_inhibitor-1 and tissue-type plasminogen activator in cultured endothelial cells .
10825233	0	nitric_oxide	61,73	INS-1	148,153	nitric oxide	INS-1	MESH:D009569	24505(Tax:10116)	Chemical	Gene	isoform|nmod|START_ENTITY activation|nmod|isoform synthase|nsubj|activation synthase|nmod|cells cells|compound|END_ENTITY	Synergistic activation of NF-kappab and inducible isoform of nitric_oxide synthase induction by interferon-gamma and tumor_necrosis_factor-alpha in INS-1 cells .
11517169	0	nitric_oxide	142,154	INS-1	167,172	nitric oxide	INS-1	MESH:D009569	2305	Chemical	Gene	synthase|amod|START_ENTITY synthase|nmod|cells cells|compound|END_ENTITY	GH inhibits interferon-gamma-induced signal_transducer_and_activator_of_transcription-1 activation and expression of the inducible isoform of nitric_oxide synthase in INS-1 cells .
11604223	0	nitric_oxide	15,27	INS-1	72,77	nitric oxide	INS-1	MESH:D009569	24505(Tax:10116)	Chemical	Gene	synthase|compound|START_ENTITY modulates|nsubj|synthase modulates|dobj|secretion secretion|nmod|line line|compound|END_ENTITY	A constitutive nitric_oxide synthase modulates insulin secretion in the INS-1 cell line .
18957297	0	nitric_oxide	42,54	INS-1	122,127	nitric oxide	INS-1	MESH:D009569	2305	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	cGMP-independent anti-apoptotic effect of nitric_oxide on thapsigargin-induced apoptosis in the pancreatic beta-cell line INS-1 .
9417885	0	nitric_oxide	121,133	INS-1	98,103	nitric oxide	INS-1	MESH:D009569	24505(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	Interferon-gamma inhibits insulin release and induces cell death in the pancreatic beta-cell line INS-1 independently of nitric_oxide production .
9770329	0	nitric_oxide	61,73	INTERLEUKIN-10	25,39	nitric oxide	INTERLEUKIN-10	MESH:D009569	3586	Chemical	Gene	synthase|amod|START_ENTITY expression|nmod|synthase END_ENTITY|nmod|expression	Regulation by endogenous INTERLEUKIN-10 of the expression of nitric_oxide synthase induced after ligation of CD23 in human macrophages .
8639920	0	nitric_oxide	44,56	IRP1	27,31	nitric oxide	IRP1	MESH:D009569	50655(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of IRP1 and IRP2 by nitric_oxide in rat hepatoma cells .
16470420	0	nitric_oxide	10,22	IRS-1	32,37	nitric oxide	IRS-1	MESH:D009569	25467(Tax:10116)	Chemical	Gene	inhibits|advmod|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Exogenous nitric_oxide inhibits IRS-1 expression in rat hepatocytes and skeletal myocytes .
23021314	0	nitric_oxide	57,69	IRT1	101,105	nitric oxide	IRT1	MESH:D009569	827713(Tax:3702)	Chemical	Gene	accumulation|amod|START_ENTITY accumulation|nmod|END_ENTITY	Gibberellic_acid alleviates cadmium toxicity by reducing nitric_oxide accumulation and expression of IRT1 in Arabidopsis_thaliana .
21122797	0	nitric_oxide	85,97	IkappaB-alpha	0,13	nitric oxide	IkappaB-alpha	MESH:D009569	25493(Tax:10116)	Chemical	Gene	modulated|nmod|START_ENTITY modulated|nsubjpass|expression expression|amod|END_ENTITY	IkappaB-alpha expression following transient focal cerebral_ischemia is modulated by nitric_oxide .
22960179	0	nitric_oxide	67,79	Inducible_nitric_oxide_synthase	0,31	nitric oxide	Inducible nitric oxide synthase	MESH:D009569	18126(Tax:10090)	Chemical	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|formation formation|amod|END_ENTITY	Inducible_nitric_oxide_synthase aggresome formation is mediated by nitric_oxide .
10868937	0	nitric_oxide	37,49	Ins-1	73,78	nitric oxide	Ins-1	MESH:D009569	24505(Tax:10116)	Chemical	Gene	expression|compound|START_ENTITY IGF-I|nmod|expression IGF-I|nmod|cells cells|compound|END_ENTITY	Inhibitory effect of IGF-I on type 2 nitric_oxide synthase expression in Ins-1 cells and protection against activation-dependent apoptosis : involvement of phosphatidylinositol 3-kinase .
10902810	0	nitric_oxide	126,138	Insulin	0,7	nitric oxide	Insulin	MESH:D009569	3630	Chemical	Gene	stimulation|nmod|START_ENTITY inhibits|nmod|stimulation inhibits|nsubj|END_ENTITY	Insulin inhibits the expression of intercellular_adhesion_molecule-1 by human_aortic_endothelial_cells through stimulation of nitric_oxide .
12444902	0	nitric_oxide	160,172	Insulin	0,7	nitric oxide	Insulin	MESH:D009569	3630	Chemical	Gene	synthase|compound|START_ENTITY activating|dobj|synthase influences|advcl|activating influences|nsubj|END_ENTITY	Insulin influences the nitric_oxide cyclic nucleotide pathway in cultured human smooth muscle cells from corpus cavernosum by rapidly activating a constitutive nitric_oxide synthase .
12444902	0	nitric_oxide	23,35	Insulin	0,7	nitric oxide	Insulin	MESH:D009569	3630	Chemical	Gene	pathway|amod|START_ENTITY influences|dobj|pathway influences|nsubj|END_ENTITY	Insulin influences the nitric_oxide cyclic nucleotide pathway in cultured human smooth muscle cells from corpus cavernosum by rapidly activating a constitutive nitric_oxide synthase .
15473891	0	nitric_oxide	99,111	Insulin	0,7	nitric oxide	Insulin	MESH:D009569	3630	Chemical	Gene	influence|nmod|START_ENTITY cells|dep|influence activates|nmod|cells activates|nsubj|END_ENTITY	Insulin activates vascular_endothelial_growth_factor in vascular smooth muscle cells : influence of nitric_oxide and of insulin resistance .
16444867	0	nitric_oxide	53,65	Insulin	0,7	nitric oxide	Insulin	MESH:D009569	3630	Chemical	Gene	ADMA|amod|START_ENTITY role|nmod|ADMA resistance|dep|role resistance|compound|END_ENTITY	Insulin resistance : potential role of the endogenous nitric_oxide synthase inhibitor ADMA .
23728590	0	nitric_oxide	46,58	Insulin	0,7	nitric oxide	Insulin	MESH:D009569	397415(Tax:9823)	Chemical	Gene	affects|nmod|START_ENTITY affects|nsubj|END_ENTITY	Insulin affects sperm capacity in pig through nitric_oxide .
7505207	0	nitric_oxide	51,63	Insulin-like_growth_factor_I	0,28	nitric oxide	Insulin-like growth factor I	MESH:D009569	24482(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY induction|nmod|synthase inhibits|dobj|induction inhibits|nsubj|END_ENTITY	Insulin-like_growth_factor_I inhibits induction of nitric_oxide synthase in vascular smooth muscle cells .
24906011	0	nitric_oxide	50,62	Integrin-linked_kinase	0,22	nitric oxide	Integrin-linked kinase	MESH:D009569	3611	Chemical	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Integrin-linked_kinase regulates endothelial cell nitric_oxide synthase expression in hepatic sinusoidal endothelial cells .
10376946	0	nitric_oxide	124,136	Interferon-gamma	0,16	nitric oxide	Interferon-gamma	MESH:D009569	15978(Tax:10090)	Chemical	Gene	formation|amod|START_ENTITY astrocytes|nmod|formation reduces|nmod|astrocytes reduces|nsubj|END_ENTITY	Interferon-gamma reduces cyclooxygenase-2-mediated prostaglandin_E2 production from primary mouse astrocytes independent of nitric_oxide formation .
10447771	0	nitric_oxide	99,111	Interferon-gamma	0,16	nitric oxide	Interferon-gamma	MESH:D009569	25712(Tax:10116)	Chemical	Gene	production|nmod|START_ENTITY regulates|nmod|production regulates|nsubj|END_ENTITY	Interferon-gamma regulates the interaction of RBL-2H3 cells with fibronectin through production of nitric_oxide .
10484680	0	nitric_oxide	50,62	Interferon-gamma	0,16	nitric oxide	Interferon-gamma	MESH:D009569	15978(Tax:10090)	Chemical	Gene	production|nmod|START_ENTITY triggers|dobj|production triggers|nsubj|END_ENTITY	Interferon-gamma alone triggers the production of nitric_oxide from serum-starved BNL_CL .2 , murine embryonic liver cells .
11347274	0	nitric_oxide	93,105	Interferon-gamma	0,16	nitric oxide	Interferon-gamma	MESH:D009569	15978(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY required|nmod|production required|nsubjpass|necrosis necrosis|amod|END_ENTITY	Interferon-gamma - and lipopolysaccharide-induced tumor necrosis factor-alpha is required for nitric_oxide production : tumor necrosis factor-alpha and nitric_oxide are independently involved in the killing of Mycobacterium microti in interferon-gamma - and lipopolysaccharide-treated J774A .1 cells .
1384487	0	nitric_oxide	79,91	Interferon-gamma	0,16	nitric oxide	Interferon-gamma	MESH:D009569	25712(Tax:10116)	Chemical	Gene	generation|amod|START_ENTITY vascular|nmod|generation vascular|nsubj|proliferation proliferation|amod|END_ENTITY	Interferon-gamma inhibits proliferation of rat vascular smooth muscle cells by nitric_oxide generation .
1394884	0	nitric_oxide	63,75	Interferon-gamma	0,16	nitric oxide	Interferon-gamma	MESH:D009569	25712(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY induce|dobj|production necrosis|advcl|induce necrosis|nsubj|END_ENTITY	Interferon-gamma and tumor necrosis factor synergize to induce nitric_oxide production and inhibit mitochondrial respiration in vascular smooth muscle cells .
17336935	0	nitric_oxide	39,51	Interferon-gamma	0,16	nitric oxide	Interferon-gamma	MESH:D009569	15978(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY mediate|dobj|production mediate|nsubj|END_ENTITY	Interferon-gamma and NF-kappaB mediate nitric_oxide production by mesenchymal stromal cells .
17662042	0	nitric_oxide	102,114	Interferon-gamma	0,16	nitric oxide	Interferon-gamma	MESH:D009569	3458	Chemical	Gene	role|nmod|START_ENTITY regulates|parataxis|role regulates|nsubj|END_ENTITY	Interferon-gamma regulates chemokine expression and release in the human mast cell line HMC1 : role of nitric_oxide .
18412158	0	nitric_oxide	75,87	Interferon-gamma	0,16	nitric oxide	Interferon-gamma	MESH:D009569	3458	Chemical	Gene	mechanism|amod|START_ENTITY lymphocyte|parataxis|mechanism lymphocyte|nsubj|Th1 Th1|amod|END_ENTITY	Interferon-gamma limits Th1 lymphocyte adhesion to inflamed endothelium : a nitric_oxide regulatory feedback mechanism .
24983769	0	nitric_oxide	69,81	Interferon-gamma	0,16	nitric oxide	Interferon-gamma	MESH:D009569	15978(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY Regulation|nmod|kinase death|dep|Regulation death|amod|END_ENTITY	Interferon-gamma induced cell death : Regulation and contributions of nitric_oxide , cJun N-terminal kinase , reactive_oxygen_species and peroxynitrite .
7512249	0	nitric_oxide	47,59	Interferon-gamma	0,16	nitric oxide	Interferon-gamma	MESH:D009569	15978(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|induce induce|amod|END_ENTITY	Interferon-gamma and interleukin-1_beta induce nitric_oxide formation from primary mouse astrocytes .
7693830	0	nitric_oxide	125,137	Interferon-gamma	0,16	nitric oxide	Interferon-gamma	MESH:D009569	15978(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY induction|nmod|production tumor_necrosis_factor-alpha|nmod|induction synergizes|nmod|tumor_necrosis_factor-alpha synergizes|nsubj|END_ENTITY	Interferon-gamma , but not interferon-alpha_beta , synergizes with tumor_necrosis_factor-alpha and lipid_A in the induction of nitric_oxide production by murine L929 cells .
8704222	0	nitric_oxide	68,80	Interferon-gamma	0,16	nitric oxide	Interferon-gamma	MESH:D009569	15978(Tax:10090)	Chemical	Gene	pathway|amod|START_ENTITY mitogen|nmod|pathway T-cell|nmod|mitogen T-cell|nsubj|suppresses suppresses|amod|END_ENTITY	Interferon-gamma suppresses T-cell proliferation to mitogen via the nitric_oxide pathway during experimental acute_graft-versus-host_disease .
22105605	0	nitric_oxide	103,115	Interferon_regulatory_factor-1	0,30	nitric oxide	Interferon regulatory factor-1	MESH:D009569	16362(Tax:10090)	Chemical	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Interferon_regulatory_factor-1 regulates the autophagic response in LPS-stimulated macrophages through nitric_oxide .
8903851	0	nitric_oxide	15,27	Interleukin-1	0,13	nitric oxide	Interleukin-1	MESH:D009569	3552	Chemical	Gene	astrocytes|nsubj|START_ENTITY astrocytes|advmod|END_ENTITY	Interleukin-1 , nitric_oxide and reactive astrocytes .
10210769	0	nitric_oxide	116,128	Interleukin-10	0,14	nitric oxide	Interleukin-10	MESH:D009569	16153(Tax:10090)	Chemical	Gene	production|nmod|START_ENTITY enhances|nmod|production enhances|nsubj|END_ENTITY	Interleukin-10 in combination with interferon-gamma and tumor_necrosis_factor-alpha enhances in vitro production of nitric_oxide by murine resident paritoneal macrophage .
11829538	0	nitric_oxide	29,41	Interleukin-10	0,14	nitric oxide	Interleukin-10	MESH:D009569	3586	Chemical	Gene	biosynthesis|amod|START_ENTITY inhibition|nmod|biosynthesis inhibition|amod|END_ENTITY	Interleukin-10 inhibition of nitric_oxide biosynthesis involves suppression of CAT-2 transcription .
1371674	0	nitric_oxide	49,61	Interleukin-10	0,14	nitric oxide	Interleukin-10	MESH:D009569	16153(Tax:10090)	Chemical	Gene	synthase|amod|START_ENTITY induction|nmod|synthase inhibits|dobj|induction inhibits|nsubj|END_ENTITY	Interleukin-10 -LRB- IL-10 -RRB- inhibits the induction of nitric_oxide synthase by interferon-gamma in murine macrophages .
7589103	0	nitric_oxide	37,49	Interleukin-10	0,14	nitric oxide	Interleukin-10	MESH:D009569	3586	Chemical	Gene	induction|compound|START_ENTITY inhibits|dobj|induction inhibits|nsubj|END_ENTITY	Interleukin-10 inhibits IgE-mediated nitric_oxide synthase induction and cytokine synthesis in normal human keratinocytes .
9268226	0	nitric_oxide	41,53	Interleukin-10	0,14	nitric oxide	Interleukin-10	MESH:D009569	3586	Chemical	Gene	release|compound|START_ENTITY stimulation|nmod|release stimulation|amod|END_ENTITY	Interleukin-10 stimulation of endogenous nitric_oxide release from human saphenous veins diminishes immunocyte adherence .
9855366	0	nitric_oxide	116,128	Interleukin-10	0,14	nitric oxide	Interleukin-10	MESH:D009569	25325(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY dependence|nmod|production evidence|nmod|dependence stimulation|dep|evidence stimulation|amod|END_ENTITY	Interleukin-10 stimulation of corticotrophin_releasing_factor median eminence in rats : evidence for dependence upon nitric_oxide production .
10919016	0	nitric_oxide	24,36	Interleukin-13	0,14	nitric oxide	Interleukin-13	MESH:D009569	3596	Chemical	Gene	production|amod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Interleukin-13 inhibits nitric_oxide production in human colonic_mucosa .
8573104	0	nitric_oxide	34,46	Interleukin-13	0,14	nitric oxide	Interleukin-13	MESH:D009569	3596	Chemical	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Interleukin-13 inhibits inducible nitric_oxide synthase expression in human mesangial cells .
11585620	0	nitric_oxide	36,48	Interleukin-17	0,14	nitric oxide	Interleukin-17	MESH:D009569	301289(Tax:10116)	Chemical	Gene	activation|amod|START_ENTITY inducible|dobj|activation inducible|nsubj|stimulates stimulates|amod|END_ENTITY	Interleukin-17 stimulates inducible nitric_oxide synthase activation in rodent astrocytes .
9182915	0	nitric_oxide	32,44	Interleukin-17	0,14	nitric oxide	Interleukin-17	MESH:D009569	3605	Chemical	Gene	production|amod|START_ENTITY up-regulation|nmod|production up-regulation|amod|END_ENTITY	Interleukin-17 up-regulation of nitric_oxide production in human osteoarthritis cartilage .
1380466	0	nitric_oxide	59,71	Interleukin-1_beta	0,18	nitric oxide	Interleukin-1 beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY isoform|nmod|synthase expression|nmod|isoform induces|dobj|expression induces|nsubj|END_ENTITY	Interleukin-1_beta induces the expression of an isoform of nitric_oxide synthase in insulin-producing cells , which is similar to that observed in activated macrophages .
1731791	0	nitric_oxide	27,39	Interleukin-1_beta	0,18	nitric oxide	Interleukin-1 beta	MESH:D009569	16176(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Interleukin-1_beta induces nitric_oxide production and inhibits the activity of aconitase without decreasing glucose oxidation rates in isolated mouse pancreatic islets .
7506289	0	nitric_oxide	27,39	Interleukin-1_beta	0,18	nitric oxide	Interleukin-1 beta	MESH:D009569	16176(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Interleukin-1_beta induces nitric_oxide production by a mouse pituitary_tumour cell line -LRB- AtT20/D16 -RRB- .
7538649	0	nitric_oxide	44,56	Interleukin-1_beta	0,18	nitric oxide	Interleukin-1 beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	formation|nmod|START_ENTITY induces|dobj|formation induces|nsubj|END_ENTITY	Interleukin-1_beta induces the formation of nitric_oxide in isolated juxtaglomerular cells : influence on renin secretion .
7540548	0	nitric_oxide	79,91	Interleukin-1_beta	0,18	nitric oxide	Interleukin-1 beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY increasing|dobj|production apoptosis|advcl|increasing apoptosis|nsubj|suppresses suppresses|amod|END_ENTITY	Interleukin-1_beta suppresses apoptosis in rat ovarian follicles by increasing nitric_oxide production .
8221802	0	nitric_oxide	94,106	Interleukin-1_beta	0,18	nitric oxide	Interleukin-1 beta	MESH:D009569	3553	Chemical	Gene	production|nmod|START_ENTITY myocardial_contraction|nmod|production modulates|dobj|myocardial_contraction modulates|nsubj|END_ENTITY	Interleukin-1_beta modulates myocardial_contraction via dexamethasone sensitive production of nitric_oxide .
8649215	0	nitric_oxide	43,55	Interleukin-1_beta	0,18	nitric oxide	Interleukin-1 beta	MESH:D009569	3553	Chemical	Gene	production|amod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Interleukin-1_beta specifically stimulates nitric_oxide production in the hypothalamus .
9359471	0	nitric_oxide	137,149	Interleukin-1_beta	0,18	nitric oxide	Interleukin-1 beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	accumulation|amod|START_ENTITY dissociated|nmod|accumulation mechanism|acl|dissociated cultures|nmod|mechanism inhibits|nsubj|cultures inhibits|dep|END_ENTITY	Interleukin-1_beta inhibits progesterone accumulation in rat corpora luteal cell cultures in a mechanism dissociated from its effects on nitric_oxide and prostaglandin_E accumulation .
10391466	0	nitric_oxide	64,76	Interleukin-1beta	0,17	nitric oxide	Interleukin-1beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	activates|ccomp|START_ENTITY activates|nsubj|END_ENTITY	Interleukin-1beta activates forebrain glial cells and increases nitric_oxide production and cortical glutamate and GABA release in vivo : implications for Alzheimer 's _ disease .
11105912	0	nitric_oxide	28,40	Interleukin-1beta	0,17	nitric oxide	Interleukin-1beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	Interleukin-1beta regulates nitric_oxide production and gamma-glutamyl_transpeptidase activity in sertoli cells .
12569071	0	nitric_oxide	140,152	Interleukin-1beta	0,17	nitric oxide	Interleukin-1beta	MESH:D009569	3553	Chemical	Gene	involvement|nmod|START_ENTITY mechanisms|dep|involvement inhibits|nmod|mechanisms inhibits|nsubj|END_ENTITY	Interleukin-1beta inhibits ATP-induced protein_kinase_B activation in renal mesangial cells by two different mechanisms : the involvement of nitric_oxide and ceramide .
16887914	0	nitric_oxide	80,92	Interleukin-1beta	0,17	nitric oxide	Interleukin-1beta	MESH:D009569	3553	Chemical	Gene	synthase|compound|START_ENTITY signals|nmod|synthase signals|nsubj|END_ENTITY	Interleukin-1beta signals through a c-Jun_N-terminal_kinase-dependent inducible nitric_oxide synthase and nitric_oxide production pathway in Sertoli epithelial cells .
17146391	0	nitric_oxide	41,53	Interleukin-1beta	0,17	nitric oxide	Interleukin-1beta	MESH:D009569	3553	Chemical	Gene	inducible|xcomp|START_ENTITY inducible|nsubj|up-regulates up-regulates|amod|END_ENTITY	Interleukin-1beta up-regulates inducible nitric_oxide by way of phosphoinositide_3-kinase-dependent in a cochlear cell model .
17210754	0	nitric_oxide	40,52	Interleukin-1beta	0,17	nitric oxide	Interleukin-1beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	form|nmod|START_ENTITY form|amod|END_ENTITY	Interleukin-1beta and inducible form of nitric_oxide synthase expression in early syngeneic islet transplantation .
19179618	0	nitric_oxide	34,46	Interleukin-1beta	0,17	nitric oxide	Interleukin-1beta	MESH:D009569	16176(Tax:10090)	Chemical	Gene	Zip14|amod|START_ENTITY contributes|nmod|Zip14 contributes|nsubj|END_ENTITY	Interleukin-1beta contributes via nitric_oxide to the upregulation and functional activity of the zinc transporter Zip14 -LRB- Slc39a14 -RRB- in murine hepatocytes .
19671357	0	nitric_oxide	109,121	Interleukin-1beta	1,18	nitric oxide	Interleukin-1beta	MESH:D009569	3553	Chemical	Gene	-RSB-|amod|START_ENTITY fibroblasts|nmod|-RSB- upregulates|nmod|fibroblasts upregulates|nsubj|END_ENTITY	-LSB- Interleukin-1beta upregulates matrix_metalloproteinase-2 expression and activity in cardiac fibroblasts via nitric_oxide synthase pathway -RSB- .
19661270	0	nitric_oxide	101,113	Interleukin-33	0,14	nitric oxide	Interleukin-33	MESH:D009569	90865	Chemical	Gene	production|compound|START_ENTITY induces|nmod|production induces|nsubj|END_ENTITY	Interleukin-33 induces angiogenesis and vascular permeability through ST2/TRAF6-mediated endothelial nitric_oxide production .
17242212	0	nitric_oxide	77,89	Interleukin-6	0,13	nitric oxide	Interleukin-6	MESH:D009569	3569	Chemical	Gene	production|nmod|START_ENTITY promoting|dobj|production signaling|advcl|promoting insulin|acl|signaling impairs|dobj|insulin impairs|nsubj|END_ENTITY	Interleukin-6 impairs the insulin signaling pathway , promoting production of nitric_oxide in human umbilical vein endothelial cells .
22069265	0	nitric_oxide	72,84	Interleukin-6	0,13	nitric oxide	Interleukin-6	MESH:D009569	3569	Chemical	Gene	production|compound|START_ENTITY apoptosis|nmod|production induces|dobj|apoptosis induces|nsubj|treatment treatment|amod|END_ENTITY	Interleukin-6 treatment induces beta-cell apoptosis via STAT-3-mediated nitric_oxide production .
12180737	0	nitric_oxide	23,35	Interleukin_17	0,14	nitric oxide	Interleukin 17	MESH:D009569	3605	Chemical	Gene	START_ENTITY|nsubj|induced induced|compound|END_ENTITY	Interleukin_17 induced nitric_oxide suppresses matrix synthesis and protects cartilage from matrix breakdown .
1334975	0	nitric_oxide	44,56	Interleukin_1_beta	0,18	nitric oxide	Interleukin 1 beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	formation|nmod|START_ENTITY induces|dobj|formation induces|nsubj|END_ENTITY	Interleukin_1_beta induces the formation of nitric_oxide by beta-cells purified from rodent islets of Langerhans .
1370409	0	nitric_oxide	80,92	Interleukin_1_beta	0,18	nitric oxide	Interleukin 1 beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY macrophage-type|nmod|synthase induce|dobj|macrophage-type necrosis|xcomp|induce necrosis|nsubj|END_ENTITY	Interleukin_1_beta and tumour necrosis factor alpha induce a macrophage-type of nitric_oxide synthase in rat renal mesangial cells .
7530059	0	nitric_oxide	104,116	Interleukin_1_beta	0,18	nitric oxide	Interleukin 1 beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	synthases|compound|START_ENTITY induction|nmod|synthases nitric_oxide|nmod|induction induces|nmod|nitric_oxide induces|nsubj|END_ENTITY	Interleukin_1_beta induces diabetes and fever in normal rats by nitric_oxide via induction of different nitric_oxide synthases .
7530059	0	nitric_oxide	64,76	Interleukin_1_beta	0,18	nitric oxide	Interleukin 1 beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Interleukin_1_beta induces diabetes and fever in normal rats by nitric_oxide via induction of different nitric_oxide synthases .
8666334	0	nitric_oxide	39,51	Interleukin_1_beta	0,18	nitric oxide	Interleukin 1 beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	formation|amod|START_ENTITY stimulates|dobj|formation stimulates|nsubj|markedly markedly|compound|END_ENTITY	Interleukin_1_beta markedly stimulates nitric_oxide formation in the absence of other cytokines or lipopolysaccharide in primary cultured rat hepatocytes but not in Kupffer cells .
8846404	0	nitric_oxide	118,130	Interleukin_1_beta	0,18	nitric oxide	Interleukin 1 beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	involvement|nmod|START_ENTITY enhances|parataxis|involvement enhances|nsubj|END_ENTITY	Interleukin_1_beta , but not tumor_necrosis_factor , enhances neurogenic vasodilatation in the rat skin : involvement of nitric_oxide .
21566147	0	nitric_oxide	119,131	Iron_regulatory_protein_1	0,25	nitric oxide	Iron regulatory protein 1	MESH:D009569	11428(Tax:10090)	Chemical	Gene	regulating|advcl|START_ENTITY outcompetes|advcl|regulating outcompetes|nsubj|END_ENTITY	Iron_regulatory_protein_1 outcompetes iron_regulatory_protein_2 in regulating cellular iron homeostasis in response to nitric_oxide .
26297979	0	nitric_oxide	30,42	JNK	56,59	nitric oxide	JNK	MESH:D009569	26419(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY synthase|nmod|END_ENTITY	Herbacetin inhibits inducible nitric_oxide synthase via JNK and nuclear factor-kB in LPS-stimulated RAW264 .7 cells .
7516994	0	nitric_oxide	14,26	Jun	60,63	nitric oxide	Jun	MESH:D009569	24516(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY synthase|nmod|END_ENTITY	Expression of nitric_oxide synthase and colocalisation with Jun , Fos and Krox transcription factors in spinal cord neurons following noxious stimulation of the rat hindpaw .
17003331	0	nitric_oxide	91,103	Jun_NH2-terminal_kinase	136,159	nitric oxide	Jun NH2-terminal kinase	MESH:D009569	116554(Tax:10116)	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Bradykinin augments insulin-stimulated glucose transport in rat adipocytes via endothelial nitric_oxide synthase-mediated inhibition of Jun_NH2-terminal_kinase .
22711891	0	nitric_oxide	29,41	Kruppel-like_factor_6	59,80	nitric oxide	Kruppel-like factor 6	MESH:D009569	1316	Chemical	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Transactivation of inducible nitric_oxide synthase gene by Kruppel-like_factor_6 regulates apoptosis during influenza_A_virus infection .
12570815	0	nitric_oxide	12,24	LHRH	44,48	nitric oxide	LHRH	MESH:D009569	25194(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|control control|nmod|END_ENTITY	The role of nitric_oxide -LRB- NO -RRB- in control of LHRH release that mediates gonadotropin release and sexual behavior .
16584085	0	nitric_oxide	12,24	LHRH	56,60	nitric oxide	LHRH	MESH:D009569	2796	Chemical	Gene	START_ENTITY|nmod|control control|nmod|END_ENTITY	The role of nitric_oxide in the hypothalamic control of LHRH and oxytocin release , sexual behavior and aging of the LHRH and oxytocin neurons .
11026756	0	nitric_oxide	17,29	LH_receptor	55,66	nitric oxide	LH receptor	MESH:D009569	3973	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Critical role of nitric_oxide in expression of porcine LH_receptor at transcription and post-transcription levels .
11481030	0	nitric_oxide	92,104	MAdCAM-1	30,38	nitric oxide	MAdCAM-1	MESH:D009569	8174	Chemical	Gene	regulated|parataxis|START_ENTITY regulated|nsubjpass|expression expression|compound|END_ENTITY	TNF-alpha induced endothelial MAdCAM-1 expression is regulated by exogenous , not endogenous nitric_oxide .
11672583	0	nitric_oxide	104,116	MCP-1	33,38	nitric oxide	MCP-1	MESH:D009569	6347	Chemical	Gene	synthase|compound|START_ENTITY role|nmod|synthase induction|dep|role induction|nmod|END_ENTITY	Activated protein C induction of MCP-1 in human endothelial cells : a possible role for endothelial cell nitric_oxide synthase .
12187099	0	nitric_oxide	80,92	MCP-1	0,5	nitric oxide	MCP-1	MESH:D009569	100360872	Chemical	Gene	inhibitor|amod|START_ENTITY treated|nmod|inhibitor cortex|acl|treated expressed|nmod|cortex expressed|nsubjpass|END_ENTITY	MCP-1 and RANTES are expressed in renal cortex of rats chronically treated with nitric_oxide synthase inhibitor .
12704652	0	nitric_oxide	117,129	MCP-1	79,84	nitric oxide	MCP-1	MESH:D009569	6347	Chemical	Gene	repressed|nmod|START_ENTITY expression|acl:relcl|repressed expression|compound|END_ENTITY	Activation of PKC-epsilon and ERK1/2 participates in shear-induced endothelial MCP-1 expression that is repressed by nitric_oxide .
17222215	0	nitric_oxide	80,92	MCP-1	0,5	nitric oxide	MCP-1	MESH:D009569	20296(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY acute_lung_injury|nmod|production regulates|dobj|acute_lung_injury END_ENTITY|appos|regulates	MCP-1 / CCR2 signalling pathway regulates hyperoxia-induced acute_lung_injury via nitric_oxide production .
16855064	0	nitric_oxide	22,34	MIP-2	38,43	nitric oxide	MIP-2	MESH:D009569	20310(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|production production|compound|END_ENTITY	A suppressive role of nitric_oxide in MIP-2 production by macrophages upon coculturing with apoptotic cells .
16636074	0	nitric_oxide	16,28	MMP-13	43,49	nitric oxide	MMP-13	MESH:D009569	17386(Tax:10090)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Cbfa-1 mediates nitric_oxide regulation of MMP-13 in osteoblasts .
11433190	0	nitric_oxide	81,93	Matrix_metalloproteinase-2	0,26	nitric oxide	Matrix metalloproteinase-2	MESH:D009569	4313	Chemical	Gene	interactions|nmod|START_ENTITY END_ENTITY|dep|interactions	Matrix_metalloproteinase-2 in platelet_adhesion to fibrinogen : interactions with nitric_oxide .
18597705	0	nitric_oxide	68,80	Matrix_metalloproteinase-2	0,26	nitric oxide	Matrix metalloproteinase-2	MESH:D009569	4313	Chemical	Gene	synthase|amod|START_ENTITY synthase|nummod|END_ENTITY	Matrix_metalloproteinase-2 matrix_metalloproteinase-9 and inducible nitric_oxide synthase in oral_leukoplakia : immunohistochemistry and RT-PCR analysis .
11196190	0	nitric_oxide	85,97	Matrix_metalloproteinase_2	0,26	nitric oxide	Matrix metalloproteinase 2	MESH:D009569	4313	Chemical	Gene	regulation|nmod|START_ENTITY END_ENTITY|dep|regulation	Matrix_metalloproteinase_2 in tumor cell-induced platelet_aggregation : regulation by nitric_oxide .
12535701	0	nitric_oxide	43,55	Melanin-concentrating_hormone	0,29	nitric oxide	Melanin-concentrating hormone	MESH:D009569	5367	Chemical	Gene	levels|compound|START_ENTITY END_ENTITY|appos|levels	Melanin-concentrating_hormone , hippocampal nitric_oxide levels and memory retention .
19554014	0	nitric_oxide	28,40	Methemoglobin	0,13	nitric oxide	Methemoglobin	MESH:D009569	3048	Chemical	Gene	ratio|compound|START_ENTITY END_ENTITY|nmod|ratio	Methemoglobin to cumulative nitric_oxide ratio and response to inhaled nitric_oxide in PPHN .
11641460	0	nitric_oxide	93,105	Monocyte_chemoattractant_protein-1	0,34	nitric oxide	Monocyte chemoattractant protein-1	MESH:D009569	6347	Chemical	Gene	exposed|nmod|START_ENTITY exposed|nsubj|END_ENTITY	Monocyte_chemoattractant_protein-1 and its receptor CCR-2 in piglet lungs exposed to inhaled nitric_oxide and hyperoxia .
7692849	0	nitric_oxide	57,69	Monocyte_chemotactic_protein-1	0,30	nitric oxide	Monocyte chemotactic protein-1	MESH:D009569	20296(Tax:10090)	Chemical	Gene	synthase|amod|START_ENTITY induction|nmod|synthase inhibits|dobj|induction inhibits|nsubj|END_ENTITY	Monocyte_chemotactic_protein-1 inhibits the induction of nitric_oxide synthase in J774 cells .
10079014	0	nitric_oxide	52,64	NF-kappaB	111,120	nitric oxide	NF-kappaB	MESH:D009569	18033(Tax:10090)	Chemical	Gene	synthase|amod|START_ENTITY synthase|acl|down-regulating down-regulating|dobj|activation activation|nmod|END_ENTITY	Theaflavin-3 ,3 ' - digallate from black tea blocks the nitric_oxide synthase by down-regulating the activation of NF-kappaB in macrophages .
10092524	0	nitric_oxide	120,132	NF-kappaB	19,28	nitric oxide	NF-kappaB	MESH:D009569	4790	Chemical	Gene	synthase|amod|START_ENTITY role|nmod|synthase indicates|dobj|role indicates|nsubj|induction induction|nmod|isolation isolation|amod|END_ENTITY	Rapid induction of NF-kappaB binding during liver cell isolation and culture : inhibition by L-NAME indicates a role for nitric_oxide synthase .
11399667	0	nitric_oxide	74,86	NF-kappaB	182,191	nitric oxide	NF-kappaB	MESH:D009569	4790	Chemical	Gene	synthase|compound|START_ENTITY inhibits|dobj|synthase inhibits|nmod|inactivation inactivation|nmod|END_ENTITY	Ergolide , sesquiterpene_lactone from Inula britannica , inhibits inducible nitric_oxide synthase and cyclo-oxygenase-2 expression in RAW 264.7 macrophages through the inactivation of NF-kappaB .
11578809	0	nitric_oxide	43,55	NF-kappaB	82,91	nitric oxide	NF-kappaB	MESH:D009569	18033(Tax:10090)	Chemical	Gene	Killing|nmod|START_ENTITY Killing|dep|involvement involvement|nmod|activity activity|amod|END_ENTITY	Killing of lymphoblastic_leukemia cells by nitric_oxide and taxol : involvement of NF-kappaB activity .
12162464	1	nitric_oxide	161,173	NF-kappaB	123,132	nitric oxide	NF-kappaB	MESH:D009569	18033(Tax:10090)	Chemical	Gene	production|compound|START_ENTITY Role|nmod|production Role|nmod|END_ENTITY	Role of NF-kappaB and STAT-1 in ozone-induced nitric_oxide production and toxicity .
12408502	0	nitric_oxide	49,61	NF-kappaB	12,21	nitric oxide	NF-kappaB	MESH:D009569	4790	Chemical	Gene	Blockade|nmod|START_ENTITY Blockade|nmod|activation activation|amod|END_ENTITY	Blockade of NF-kappaB activation and donation of nitric_oxide : new treatment options in inflammatory_bowel_disease ?
12556970	0	nitric_oxide	113,125	NF-kappaB	0,9	nitric oxide	NF-kappaB	MESH:D009569	18033(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY downregulation|nmod|synthase impairs|nmod|downregulation impairs|nsubj|inhibition inhibition|amod|END_ENTITY	NF-kappaB inhibition impairs the radioresponse of hypoxic EMT-6 tumour cells through downregulation of inducible nitric_oxide synthase .
12929133	0	nitric_oxide	36,48	NF-kappaB	116,125	nitric oxide	NF-kappaB	MESH:D009569	18033(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY expression|nmod|synthase mediated|nsubjpass|expression mediated|nmod|END_ENTITY	Synergistic expression of inducible nitric_oxide synthase by phorbol_ester and interferon-gamma is mediated through NF-kappaB and ERK in microglial cells .
15829434	0	nitric_oxide	40,52	NF-kappaB	76,85	nitric oxide	NF-kappaB	MESH:D009569	18033(Tax:10090)	Chemical	Gene	synthase|amod|START_ENTITY induction|nmod|synthase inhibits|dobj|induction inhibits|advcl|inhibiting inhibiting|dobj|activation activation|amod|END_ENTITY	Amentoflavone inhibits the induction of nitric_oxide synthase by inhibiting NF-kappaB activation in macrophages .
16076490	0	nitric_oxide	65,77	NF-kappaB	15,24	nitric oxide	NF-kappaB	MESH:D009569	4790	Chemical	Gene	effects|nmod|START_ENTITY Involvement|nmod|effects Involvement|nmod|END_ENTITY	Involvement of NF-kappaB and glutathione in cytotoxic effects of nitric_oxide and taxol on human leukemia cells .
16457781	0	nitric_oxide	30,42	NF-kappaB	113,122	nitric oxide	NF-kappaB	MESH:D009569	18033(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY inducible|dobj|expression inducible|nmod|down-regulation down-regulation|nmod|activity activity|compound|END_ENTITY	Rengyolone inhibits inducible nitric_oxide synthase expression and nitric_oxide production by down-regulation of NF-kappaB and p38 MAP kinase activity in LPS-stimulated RAW 264.7 cells .
17374495	0	nitric_oxide	74,86	NF-kappaB	14,23	nitric oxide	NF-kappaB	MESH:D009569	4790	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|activation activation|amod|END_ENTITY	Regulation of NF-kappaB activation and nuclear translocation by exogenous nitric_oxide -LRB- NO -RRB- donors in TNF-alpha activated vascular endothelial cells .
17542608	0	nitric_oxide	136,148	NF-kappaB	178,187	nitric oxide	NF-kappaB	MESH:D009569	18033(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|expression expression|nmod|pathways pathways|compound|END_ENTITY	Anti-inflammatory effect of alpha-linolenic_acid and its mode of action through the inhibition of nitric_oxide production and inducible nitric_oxide synthase gene expression via NF-kappaB and mitogen-activated protein kinase pathways .
18050214	0	nitric_oxide	90,102	NF-kappaB	116,125	nitric oxide	NF-kappaB	MESH:D009569	4790	Chemical	Gene	synthase|compound|START_ENTITY synthase|nmod|END_ENTITY	Involvement of protein_kinase_Czeta in interleukin-1beta induction of ADAMTS-4 and type 2 nitric_oxide synthase via NF-kappaB signaling in primary human osteoarthritic chondrocytes .
18446841	0	nitric_oxide	119,131	NF-kappaB	146,155	nitric oxide	NF-kappaB	MESH:D009569	18033(Tax:10090)	Chemical	Gene	START_ENTITY|advcl|inhibiting inhibiting|dobj|activation activation|amod|END_ENTITY	A combined extract of Cinnamomi Ramulus , Anemarrhenae Rhizoma and Alpiniae Officinari Rhizoma suppresses production of nitric_oxide by inhibiting NF-kappaB activation in RAW 264.7 cells .
19114679	0	nitric_oxide	133,145	NF-kappaB	9,18	nitric oxide	NF-kappaB	MESH:D009569	4790	Chemical	Gene	START_ENTITY|nsubj|Roles Roles|nmod|activation activation|amod|END_ENTITY	Roles of NF-kappaB activation and peroxisome_proliferator-activated_receptor_gamma inhibition in the effect of rifampin on inducible nitric_oxide synthase transcription in human lung epithelial cells .
19654051	0	nitric_oxide	85,97	NF-kappaB	18,27	nitric oxide	NF-kappaB	MESH:D009569	4790	Chemical	Gene	START_ENTITY|nsubj|role role|acl|END_ENTITY	Prominent role of NF-kappaB in the induction of endothelial activation by endogenous nitric_oxide inhibition .
8710491	0	nitric_oxide	39,51	NF-kappaB	14,23	nitric oxide	NF-kappaB	MESH:D009569	4790	Chemical	Gene	binding|nmod|START_ENTITY binding|nsubj|Inhibition Inhibition|nmod|DNA DNA|compound|END_ENTITY	Inhibition of NF-kappaB DNA binding by nitric_oxide .
9065784	0	nitric_oxide	23,35	NF-kappaB	77,86	nitric oxide	NF-kappaB	MESH:D009569	4790	Chemical	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|advcl|inhibiting inhibiting|xcomp|binding binding|advmod|END_ENTITY	Nitric_oxide regulates nitric_oxide synthase-2 gene expression by inhibiting NF-kappaB binding to DNA .
9461573	0	nitric_oxide	95,107	NF-kappaB	14,23	nitric oxide	NF-kappaB	MESH:D009569	18033(Tax:10090)	Chemical	Gene	activity|amod|START_ENTITY repeat|nmod|activity repeat|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of NF-kappaB and HIV-1 long terminal repeat transcriptional activation by inducible nitric_oxide synthase 2 activity .
9510192	0	nitric_oxide	96,108	NF-kappaB	140,149	nitric oxide	NF-kappaB	MESH:D009569	18033(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY expression|nmod|synthase attenuates|dobj|expression attenuates|nmod|decrease decrease|nmod|activation activation|amod|END_ENTITY	Triggering of peritoneal macrophages with IFN-alpha/beta attenuates the expression of inducible nitric_oxide synthase through a decrease in NF-kappaB activation .
9754583	0	nitric_oxide	124,136	NF-kappaB	67,76	nitric oxide	NF-kappaB	MESH:D009569	18033(Tax:10090)	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Hyporesponsiveness to lipopolysaccharide alters the composition of NF-kappaB binding to the regulatory regions of inducible nitric_oxide synthase gene .
9820155	0	nitric_oxide	132,144	NF-kappaB	0,9	nitric oxide	NF-kappaB	MESH:D009569	4790	Chemical	Gene	production|compound|START_ENTITY herpes_simplex_virus_type_2_infection|nmod|production effect|nmod|herpes_simplex_virus_type_2_infection responsible|nmod|effect responsible|nsubj|activation activation|amod|END_ENTITY	NF-kappaB activation is responsible for the synergistic effect of herpes_simplex_virus_type_2_infection on interferon-gamma-induced nitric_oxide production in macrophages .
15019093	0	nitric_oxide	12,24	NFkappaB	67,75	nitric oxide	NFkappaB	MESH:D009569	4790	Chemical	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	The role of nitric_oxide in the particulate matter -LRB- PM2 .5 -RRB- - induced NFkappaB activation in lung epithelial cells .
12181191	0	nitric_oxide	22,34	NHE3	14,18	nitric oxide	NHE3	MESH:D009569	6550	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of NHE3 by nitric_oxide in Caco-2 cells .
11146102	0	nitric_oxide	70,82	NMDAR	135,140	nitric oxide	NMDAR	MESH:D009569	14810(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Differential expression of alternatively spliced isoforms of neuronal nitric_oxide synthase -LRB- nNOS -RRB- and N-methyl-D-aspartate_receptors -LRB- NMDAR -RRB- in knockout mice deficient in nNOS alpha -LRB- nNOS alpha -LRB- Delta/Delta -RRB- mice -RRB- .
15223068	0	nitric_oxide	120,132	NNOS	32,36	nitric oxide	NNOS	MESH:D009569	24598(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY expression|dep|production resulting|dobj|expression catalyzes|advcl|resulting catalyzes|nsubj|synthase synthase|appos|END_ENTITY	Neuronal nitric_oxide synthase -LRB- NNOS -RRB- catalyzes one-electron reduction of 2,4,6-trinitrotoluene , resulting in decreased nitric_oxide production and increased nNOS gene expression : implication for oxidative stress .
15223068	0	nitric_oxide	9,21	NNOS	32,36	nitric oxide	NNOS	MESH:D009569	24598(Tax:10116)	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Neuronal nitric_oxide synthase -LRB- NNOS -RRB- catalyzes one-electron reduction of 2,4,6-trinitrotoluene , resulting in decreased nitric_oxide production and increased nNOS gene expression : implication for oxidative stress .
10374872	0	nitric_oxide	24,36	NOS	47,50	nitric oxide	NOS	MESH:D009569	4843	Chemical	Gene	synthase|compound|START_ENTITY Expression|nmod|synthase Expression|appos|END_ENTITY	Expression of inducible nitric_oxide synthase -LRB- NOS -RRB- in bone_marrow_cells_of_myelodysplastic_syndromes .
10374875	0	nitric_oxide	23,35	NOS	150,153	nitric oxide	NOS	MESH:D009569	4843	Chemical	Gene	mRNA|amod|START_ENTITY Detection|nmod|mRNA Detection|dep|features features|nmod|inhibitor inhibitor|compound|END_ENTITY	Detection of inducible nitric_oxide synthase -LRB- iNOS -RRB- mRNA by RT-PCR in ATL patients and HTLV-I infected cell lines : clinical features and apoptosis by NOS inhibitor .
10479675	0	nitric_oxide	30,42	NOS	121,124	nitric oxide	NOS	MESH:D009569	4842	Chemical	Gene	protein|amod|START_ENTITY expression|nmod|protein suppressed|nsubjpass|expression suppressed|nmod|RNA RNA|acl|transcribed transcribed|nmod|pseudogene pseudogene|compound|END_ENTITY	Neuronal expression of neural nitric_oxide synthase -LRB- nNOS -RRB- protein is suppressed by an antisense RNA transcribed from an NOS pseudogene .
10569620	0	nitric_oxide	33,45	NOS	136,139	nitric oxide	NOS	MESH:D009569	4843	Chemical	Gene	responses|compound|START_ENTITY enhances|dobj|responses enhances|advcl|upregulating upregulating|dobj|isoforms isoforms|compound|END_ENTITY	Repeated PGE1 treatment enhances nitric_oxide and erection responses to nerve stimulation in the rat penis by upregulating constitutive NOS isoforms .
10754269	1	nitric_oxide	290,302	NOS	468,471	nitric oxide	NOS	MESH:D009569	4843	Chemical	Gene	produce|dobj|START_ENTITY produce|advcl|added added|xcomp|suggesting suggesting|ccomp|product product|nmod|END_ENTITY	Purified neuronal nitric_oxide_synthase -LRB- NOS -RRB- does not produce nitric_oxide -LRB- NO -RRB- unless high concentrations of superoxide_dismutase -LRB- SOD -RRB- are added , suggesting that nitroxyl -LRB- NO -LRB- - -RRB- -RRB- or a related molecule is the principal reaction product of NOS , which is SOD-dependently converted to NO .
10769671	0	nitric_oxide	14,26	NOS	46,49	nitric oxide	NOS	MESH:D009569	4843	Chemical	Gene	isozymes|amod|START_ENTITY Expression|nmod|isozymes Expression|appos|I-III I-III|compound|END_ENTITY	Expression of nitric_oxide synthase isozymes -LRB- NOS I-III -RRB- by immunohistochemistry and DNA in situ hybridization .
10992251	0	nitric_oxide	19,31	NOS	42,45	nitric oxide	NOS	MESH:D009569	100135576(Tax:10141)	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Origin of neuronal nitric_oxide synthase -LRB- NOS -RRB- - immunoreactive fibers in guinea_pig parasympathetic cardiac_ganglia .
11022034	1	nitric_oxide	170,182	NOS	276,279	nitric oxide	NOS	MESH:D009569	4843	Chemical	Gene	synthesis|compound|START_ENTITY stimulate|dobj|synthesis stimulate|advcl|affecting affecting|dobj|expression expression|appos|END_ENTITY	Ascorbic_acid has been shown to stimulate endothelial nitric_oxide -LRB- NO -RRB- synthesis in a time - and concentration-dependent fashion without affecting NO_synthase -LRB- NOS -RRB- expression or l-arginine uptake .
11564648	0	nitric_oxide	9,21	NOS	102,105	nitric oxide	NOS	MESH:D009569	18125(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY regulates|nsubj|synthase regulates|nmod|mice mice|compound|END_ENTITY	Neuronal nitric_oxide synthase -LRB- NOS -RRB- regulates leukocyte-endothelial cell interactions in endothelial NOS deficient mice .
11564648	0	nitric_oxide	9,21	NOS	32,35	nitric oxide	NOS	MESH:D009569	18125(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Neuronal nitric_oxide synthase -LRB- NOS -RRB- regulates leukocyte-endothelial cell interactions in endothelial NOS deficient mice .
12111751	0	nitric_oxide	54,66	NOS	77,80	nitric oxide	NOS	MESH:D009569	4843	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	Current trends in QSAR on NO donors and inhibitors of nitric_oxide synthase -LRB- NOS -RRB- * .
12533411	0	nitric_oxide	21,33	NOS	44,47	nitric oxide	NOS	MESH:D009569	18125(Tax:10090)	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	Protein inhibitor of nitric_oxide synthase -LRB- NOS -RRB- and the N-methyl-D-aspartate receptor are expressed in the rat and mouse penile nerves and colocalize with penile neuronal NOS .
12722794	0	nitric_oxide	37,49	NOS	60,63	nitric oxide	NOS	MESH:D009569	4843	Chemical	Gene	synthase|amod|START_ENTITY demonstration|nmod|synthase demonstration|appos|END_ENTITY	Immunohistochemical demonstration of nitric_oxide synthase -LRB- NOS -RRB- in the normal rat pituitary gland , estrogen-induced rat pituitary_tumor and human pituitary_adenomas .
13678705	0	nitric_oxide	70,82	NOS	37,40	nitric oxide	NOS	MESH:D009569	4843	Chemical	Gene	L-arginine|acl|START_ENTITY conversion|nmod|L-arginine conversion|appos|END_ENTITY	Inhibition of nitric_oxide_synthase -LRB- NOS -RRB- conversion of L-arginine to nitric_oxide -LRB- NO -RRB- decreases low density mononuclear cell -LRB- LD MNC -RRB- trans-endothelial migration and cytokine output .
1385308	0	nitric_oxide	22,34	NOS	45,48	nitric oxide	NOS	MESH:D009569	4843	Chemical	Gene	synthase|compound|START_ENTITY Localization|nmod|synthase Localization|appos|END_ENTITY	Localization of brain nitric_oxide synthase -LRB- NOS -RRB- to human chromosome 12 .
14628341	0	nitric_oxide	15,27	NOS	38,41	nitric oxide	NOS	MESH:D009569	4843	Chemical	Gene	synthase|amod|START_ENTITY mRNA|amod|synthase mRNA|appos|END_ENTITY	-LSB- Expression of nitric_oxide synthase -LRB- NOS -RRB- mRNA in the gonad of Oncomelania_hupensis cultured in different temperature -RSB- .
15469236	0	nitric_oxide	61,73	NOS	127,130	nitric oxide	NOS	MESH:D009569	4843	Chemical	Gene	synthase|compound|START_ENTITY domain|nmod|synthase transfer|nmod|domain transfer|parataxis|exploring exploring|dobj|properties properties|nmod|enzymes enzymes|compound|END_ENTITY	Direct electron transfer to the oxygenase domain of neuronal nitric_oxide synthase -LRB- NOS -RRB- : exploring unique redox properties of NOS enzymes .
15469236	0	nitric_oxide	61,73	NOS	84,87	nitric oxide	NOS	MESH:D009569	4843	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Direct electron transfer to the oxygenase domain of neuronal nitric_oxide synthase -LRB- NOS -RRB- : exploring unique redox properties of NOS enzymes .
15689555	0	nitric_oxide	46,58	NOS	69,72	nitric oxide	NOS	MESH:D009569	4842	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	Timed and targeted differential regulation of nitric_oxide synthase -LRB- NOS -RRB- and anti-NOS genes by reward conditioning leading to long-term memory formation .
16087361	0	nitric_oxide	22,34	NOS	131,134	nitric oxide	NOS	MESH:D009569	18125(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY role|nmod|synthase role|dep|study study|nmod|mice mice|nmod|isoforms isoforms|compound|END_ENTITY	The role of inducible nitric_oxide synthase in gamete interaction and fertilization : a comparative study on knockout mice of three NOS isoforms .
16842203	0	nitric_oxide	51,63	NOS	74,77	nitric oxide	NOS	MESH:D009569	4843	Chemical	Gene	synthase|amod|START_ENTITY enzymes|amod|synthase enzymes|appos|END_ENTITY	Computational studies of competitive inhibitors of nitric_oxide synthase -LRB- NOS -RRB- enzymes : towards the development of powerful and isoform-selective inhibitors .
17122636	0	nitric_oxide	36,48	NOS	60,63	nitric oxide	NOS	MESH:D009569	4843	Chemical	Gene	synthases|amod|START_ENTITY synthases|appos|END_ENTITY	Sarcomas often express constitutive nitric_oxide synthases -LRB- NOS -RRB- but infrequently inducible NOS .
17266598	0	nitric_oxide	30,42	NOS	64,67	nitric oxide	NOS	MESH:D009569	4843	Chemical	Gene	signaling|amod|START_ENTITY manipulation|nmod|signaling manipulation|dep|dimerization dimerization|compound|END_ENTITY	Pharmacologic manipulation of nitric_oxide signaling : targeting NOS dimerization and protein-protein interactions .
17282688	4	nitric_oxide	654,666	NOS	677,680	nitric oxide	NOS	MESH:D009569	4843	Chemical	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	After measurement of ventricular-dynamic parameters , mitochondrial and cytoplasmic fractions were isolated and their nitric_oxide synthase -LRB- NOS -RRB- activity was assessed using a NOS activity assay kit .
17313973	0	nitric_oxide	14,26	NOS	37,40	nitric oxide	NOS	MESH:D009569	4843	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Fibre-related nitric_oxide synthase -LRB- NOS -RRB- in Duchenne_muscular_dystrophy .
17388895	0	nitric_oxide	14,26	NOS	37,40	nitric oxide	NOS	MESH:D009569	4843	Chemical	Gene	synthase|amod|START_ENTITY Inhibition|nmod|synthase Inhibition|appos|END_ENTITY	Inhibition of nitric_oxide synthase -LRB- NOS -RRB- underlies aluminum-induced inhibition of root elongation in Hibiscus moscheutos .
19652483	0	nitric_oxide	36,48	NOS	59,62	nitric oxide	NOS	MESH:D009569	18125(Tax:10090)	Chemical	Gene	synthase|amod|START_ENTITY localization|nmod|synthase localization|appos|END_ENTITY	Immunohistochemical localization of nitric_oxide synthase -LRB- NOS -RRB- in mouse mammary gland during reproductive cycle .
21618236	6	nitric_oxide	910,922	NOS	933,936	nitric oxide	VIP	MESH:D009569	7432	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	Conversely , only 22 % of gastric myenteric neurons express nitric_oxide synthase -LRB- NOS -RRB- compared to 52 % in the rectum .
21889045	0	nitric_oxide	19,31	NOS	42,45	nitric oxide	NOS	MESH:D009569	4843	Chemical	Gene	synthase|compound|START_ENTITY hunt|nmod|synthase hunt|appos|END_ENTITY	The hunt for plant nitric_oxide synthase -LRB- NOS -RRB- : is one really needed ?
23572278	0	nitric_oxide	24,36	NOS	47,50	nitric oxide	NOS	MESH:D009569	4842	Chemical	Gene	synthase|amod|START_ENTITY genes|amod|synthase genes|appos|END_ENTITY	Common polymorphisms in nitric_oxide synthase -LRB- NOS -RRB- genes influence quality of aging and longevity in humans .
24176048	0	nitric_oxide	17,29	NOS	40,43	nitric oxide	NOS	MESH:D009569	4843	Chemical	Gene	synthase|amod|START_ENTITY cycling|nmod|synthase cycling|appos|END_ENTITY	Daily cycling of nitric_oxide synthase -LRB- NOS -RRB- in the hippocampus of pigeons -LRB- C. _ livia -RRB- .
25033468	0	nitric_oxide	37,49	NOS	60,63	nitric oxide	NOS	MESH:D009569	4843	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	-LSB- Ureido - N -RSB- citrulline UPLC-MS/MS nitric_oxide synthase -LRB- NOS -RRB- activity assay : development , validation , and applications to assess NOS uncoupling and human platelets NOS activity .
25680459	0	nitric_oxide	55,67	NOS	40,43	nitric oxide	NOS	MESH:D009569	4843	Chemical	Gene	production|amod|START_ENTITY activity|appos|production activity|appos|END_ENTITY	Flavone inhibits nitric_oxide_synthase -LRB- NOS -RRB- activity , nitric_oxide production and protein S-nitrosylation in breast_cancer cells .
7478274	0	nitric_oxide	4,16	NOS	27,30	nitric oxide	NOS	MESH:D009569	4843	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	The nitric_oxide synthase -LRB- NOS -RRB- - like immunoreactive extrahypophysial projections of the neurosecretory preoptic nucleus of the electric ray -LRB- elasmobranchs -RRB- suggest a neuroregulatory role for this nucleus .
7544394	0	nitric_oxide	59,71	NOS	82,85	nitric oxide	NOS	MESH:D009569	4843	Chemical	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Erythrocyte stages of Plasmodium_falciparum exhibit a high nitric_oxide synthase -LRB- NOS -RRB- activity and release an NOS-inducing soluble factor .
8625511	0	nitric_oxide	11,23	NOS	34,37	nitric oxide	NOS	MESH:D009569	18125(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Macrophage nitric_oxide synthase -LRB- NOS -RRB- activation by Nocardia_opaca fractions and 15 - and 56-kD isolated antigens .
8900922	0	nitric_oxide	73,85	NOS	96,99	nitric oxide	NOS	MESH:D009569	18125(Tax:10090)	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	Immunomodulation by OK-432 and calcitonin_gene-related_peptide -LRB- CGRP -RRB- of nitric_oxide synthase -LRB- NOS -RRB- and IL-1_beta gene expression and of HSV-1 pathogenicity in mouse skin Langerhans cells -LRB- LC -RRB- .
9171323	0	nitric_oxide	30,42	NOS	53,56	nitric oxide	NOS	MESH:D009569	4842	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	Histological determination of nitric_oxide synthase -LRB- NOS -RRB- and NADPH-diaphorase in ragged-red fibers from patients with mitochondrial encephalomyopathies .
9226999	0	nitric_oxide	33,45	NOS	62,65	nitric oxide	NOS	MESH:D009569	4842	Chemical	Gene	synthase|compound|START_ENTITY inhibitors|nmod|synthase is|dobj|inhibitors is|nsubj|NOS NOS|compound|END_ENTITY	Selective inhibitors of neuronal nitric_oxide synthase -- is no NOS really good NOS for the nervous system ?
9226999	0	nitric_oxide	33,45	NOS	78,81	nitric oxide	NOS	MESH:D009569	4842	Chemical	Gene	synthase|compound|START_ENTITY inhibitors|nmod|synthase is|dobj|inhibitors is|nsubj|END_ENTITY	Selective inhibitors of neuronal nitric_oxide synthase -- is no NOS really good NOS for the nervous system ?
9409638	0	nitric_oxide	14,26	NOS	37,40	nitric oxide	NOS	MESH:D009569	18125(Tax:10090)	Chemical	Gene	synthase|amod|START_ENTITY Inhibition|nmod|synthase Inhibition|appos|END_ENTITY	Inhibition of nitric_oxide synthase -LRB- NOS -RRB- aggravates Staphylococcus_aureus_septicaemia and septic_arthritis .
9518666	0	nitric_oxide	21,33	NOS	44,47	nitric oxide	NOS	MESH:D009569	100135576(Tax:10141)	Chemical	Gene	Evidence|nmod|START_ENTITY synthase|nsubj|Evidence synthase|xcomp|activity activity|dep|END_ENTITY	Evidence for reduced nitric_oxide synthase -LRB- NOS -RRB- activity in the ipsilateral medial vestibular nucleus and bilateral prepositus hypoglossi following unilateral vestibular deafferentation in the guinea_pig .
9553970	0	nitric_oxide	16,28	NOS	48,51	nitric oxide	NOS	MESH:D009569	100135576(Tax:10141)	Chemical	Gene	isoforms|amod|START_ENTITY Localization|nmod|isoforms Localization|appos|I I|compound|END_ENTITY	Localization of nitric_oxide synthase isoforms -LRB- NOS I , II and III -RRB- in the vestibular end organs of the guinea_pig .
23619128	6	nitric_oxide	1816,1828	NOS-1	1781,1786	nitric oxide	NOS-1	MESH:D009569	24598(Tax:10116)	Chemical	Gene	content|nsubj|START_ENTITY attenuated|xcomp|content attenuated|nsubj|knockdown knockdown|nmod|END_ENTITY	Short-interfering RNA-mediated knockdown of NOS-1 or NOX4 attenuated increased nitric_oxide and H2O2 content , respectively , in stretched-cell-conditioned medium .
16389274	0	nitric_oxide	11,23	NOS-I	34,39	nitric oxide	NOS-I	MESH:D009569	4842	Chemical	Gene	synthase|amod|START_ENTITY haplotype|amod|synthase haplotype|appos|END_ENTITY	A neuronal nitric_oxide synthase -LRB- NOS-I -RRB- haplotype associated with schizophrenia modifies prefrontal cortex function .
17459722	0	nitric_oxide	9,21	NOS-I	32,37	nitric oxide	NOS-I	MESH:D009569	18125(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Neuronal nitric_oxide synthase -LRB- NOS-I -RRB- knockout increases the survival rate of neural cells in the hippocampus independently of BDNF .
9627184	0	nitric_oxide	35,47	NOS-I	58,63	nitric oxide	NOS-I	MESH:D009569	18125(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	In situ identification of neuronal nitric_oxide synthase -LRB- NOS-I -RRB- mRNA in mouse and rat skeletal muscle .
11112111	0	nitric_oxide	8,20	NOS1	63,67	nitric oxide	NOS1	MESH:D009569	4842	Chemical	Gene	START_ENTITY|dep|association association|nmod|genotype genotype|compound|END_ENTITY	Exhaled nitric_oxide in patients with asthma : association with NOS1 genotype .
11890749	0	nitric_oxide	6,18	NOS1	98,102	nitric oxide	NOS1	MESH:D009569	4842	Chemical	Gene	levels|compound|START_ENTITY associated|nsubjpass|levels associated|nmod|polymorphism polymorphism|amod|NO_synthase NO_synthase|dep|END_ENTITY	Nasal nitric_oxide levels in cystic_fibrosis patients are associated with a neuronal NO_synthase -LRB- NOS1 -RRB- gene polymorphism .
12140778	0	nitric_oxide	36,48	NOS1	59,63	nitric oxide	NOS1	MESH:D009569	4842	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Allelic association of the neuronal nitric_oxide synthase -LRB- NOS1 -RRB- gene with schizophrenia .
12200626	0	nitric_oxide	17,29	NOS1	40,44	nitric oxide	NOS1	MESH:D009569	4842	Chemical	Gene	START_ENTITY|dobj|antigen antigen|appos|END_ENTITY	Reduced neuronal nitric_oxide synthase -LRB- NOS1 -RRB- antigen in sacral motor neurones in motor_neurone_disease .
12787407	0	nitric_oxide	142,154	NOS1	14,18	nitric oxide	NOS1	MESH:D009569	4842	Chemical	Gene	action|nmod|START_ENTITY evidence|nmod|action Expression|dep|evidence Expression|nmod|END_ENTITY	Expression of NOS1 and soluble guanylyl cyclase by human kidney epithelial cells : morphological evidence for an autocrine/paracrine action of nitric_oxide .
14759629	0	nitric_oxide	28,40	NOS1	56,60	nitric oxide	NOS1	MESH:D009569	4842	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Investigation of a neuronal nitric_oxide synthase gene -LRB- NOS1 -RRB- polymorphism in a multiple_sclerosis population .
15491847	0	nitric_oxide	44,56	NOS1	67,71	nitric oxide	NOS1	MESH:D009569	24598(Tax:10116)	Chemical	Gene	synthase|compound|START_ENTITY inhibition|nmod|synthase Effects|nmod|inhibition Effects|appos|END_ENTITY	Effects of long-term inhibition of neuronal nitric_oxide synthase -LRB- NOS1 -RRB- in uninephrectomized diabetic rats .
17320763	0	nitric_oxide	26,38	NOS1	118,122	nitric oxide	NOS1	MESH:D009569	4842	Chemical	Gene	release|compound|START_ENTITY release|dep|pathways pathways|nmod|nitric_oxide_synthase nitric_oxide_synthase|appos|END_ENTITY	Vascular and perivascular nitric_oxide release and transport : biochemical pathways of neuronal nitric_oxide_synthase -LRB- NOS1 -RRB- and endothelial_nitric_oxide_synthase -LRB- NOS3 -RRB- .
17892518	0	nitric_oxide	64,76	NOS1	89,93	nitric oxide	NOS1	MESH:D009569	24598(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	Endothelin -LRB- A -RRB- -LRB- ET -LRB- A -RRB- -RRB- and ET -LRB- B -RRB- receptor-mediated regulation of nitric_oxide synthase 1 -LRB- NOS1 -RRB- and NOS3 isoforms in the renal inner medulla .
17949925	0	nitric_oxide	56,68	NOS1	79,83	nitric oxide	NOS1	MESH:D009569	4842	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The untranslated region of exon 2 of the human neuronal nitric_oxide synthase -LRB- NOS1 -RRB- gene exerts regulatory activity .
18058820	0	nitric_oxide	25,37	NOS1	54,58	nitric oxide	NOS1	MESH:D009569	4842	Chemical	Gene	gene|amod|START_ENTITY gene|appos|nNOS nNOS|dep|END_ENTITY	Variants in the neuronal nitric_oxide synthase -LRB- nNOS , NOS1 -RRB- gene are associated with restless_legs_syndrome .
20016223	0	nitric_oxide	69,81	NOS1	99,103	nitric oxide	NOS1	MESH:D009569	4842	Chemical	Gene	polymorphisms|nmod|START_ENTITY analysis|nmod|polymorphisms synthase|nsubj|analysis synthase|dobj|gene gene|appos|END_ENTITY	Genetic association analysis of functional polymorphisms in neuronal nitric_oxide synthase 1 gene -LRB- NOS1 -RRB- and mood_disorders and fluvoxamine response in major_depressive_disorder in the Japanese population .
22008325	0	nitric_oxide	50,62	NOS1	73,77	nitric oxide	NOS1	MESH:D009569	4842	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Genomic variants in the coding region of neuronal nitric_oxide synthase -LRB- NOS1 -RRB- in infantile hypertrophic_pyloric_stenosis .
23826716	0	nitric_oxide	24,36	NOS1	48,52	nitric oxide	NOS1	MESH:D009569	4842	Chemical	Gene	synthases|amod|START_ENTITY analysis|nmod|synthases analysis|dep|END_ENTITY	Association analysis of nitric_oxide synthases : NOS1 , NOS2A and NOS3 genes , with multiple_sclerosis .
24917196	0	nitric_oxide	9,21	NOS1	32,36	nitric oxide	NOS1	MESH:D009569	4842	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Neuronal nitric_oxide synthase -LRB- NOS1 -RRB- polymorphisms interact with financial hardship to affect depression risk .
25612209	0	nitric_oxide	9,21	NOS1	32,36	nitric oxide	NOS1	MESH:D009569	4842	Chemical	Gene	START_ENTITY|dobj|synthase synthase|appos|END_ENTITY	Neuronal nitric_oxide synthase -LRB- NOS1 -RRB- and its adaptor , NOS1AP , as a genetic risk factors for psychiatric_disorders .
7528745	0	nitric_oxide	46,58	NOS1	74,78	nitric oxide	NOS1	MESH:D009569	4842	Chemical	Gene	START_ENTITY|dobj|gene gene|appos|END_ENTITY	Structural organization of the human neuronal nitric_oxide synthase gene -LRB- NOS1 -RRB- .
7685260	0	nitric_oxide	57,69	NOS1	80,84	nitric oxide	NOS1	MESH:D009569	4842	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Regional localization of the gene coding for human brain nitric_oxide synthase -LRB- NOS1 -RRB- to 12q24 .2 -- > 24.31 by fluorescent in situ hybridization .
8571963	0	nitric_oxide	34,46	NOS1	62,66	nitric oxide	NOS1	MESH:D009569	4842	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic evidence for the neuronal nitric_oxide synthase gene -LRB- NOS1 -RRB- as a susceptibility locus for infantile_pyloric_stenosis .
10023979	0	nitric_oxide	10,22	NOS2	33,37	nitric oxide	NOS2	MESH:D009569	4843	Chemical	Gene	START_ENTITY|dobj|polymorphism polymorphism|amod|synthase synthase|dep|END_ENTITY	Inducible nitric_oxide synthase -LRB- NOS2 -RRB- gene polymorphism and parasitic_diseases .
10919635	0	nitric_oxide	83,95	NOS2	106,110	nitric oxide	NOS2	MESH:D009569	4843	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Human mesothelioma samples overexpress both cyclooxygenase-2 -LRB- COX-2 -RRB- and inducible nitric_oxide synthase -LRB- NOS2 -RRB- : in vitro antiproliferative effects of a COX-2 inhibitor .
11056164	1	nitric_oxide	228,240	NOS2	194,198	nitric oxide	NOS2	MESH:D009569	4843	Chemical	Gene	production|nmod|START_ENTITY catalyzes|dobj|production catalyzes|nsubj|isoform isoform|appos|END_ENTITY	The inducible isoform of nitric-oxide_synthase -LRB- NOS2 -RRB- catalyzes the production of nitric_oxide -LRB- NO -RRB- , which participates in the pathophysiology of systemic inflammatory diseases such as sepsis .
11196682	0	nitric_oxide	64,76	NOS2	92,96	nitric oxide	NOS2	MESH:D009569	4843	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	No evidence for linkage in the promoter region of the inducible nitric_oxide synthase gene -LRB- NOS2 -RRB- in a Danish type 1 diabetes population .
11271626	0	nitric_oxide	8,20	NOS2	31,35	nitric oxide	NOS2	MESH:D009569	4843	Chemical	Gene	correlates|amod|START_ENTITY correlates|appos|END_ENTITY	Type II nitric_oxide synthase -LRB- NOS2 -RRB- expression correlates with lymph node status in oral_squamous_cell_carcinoma .
11343416	0	nitric_oxide	35,47	NOS2	58,62	nitric oxide	NOS2	MESH:D009569	24599(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	Retinoic_acid attenuates inducible nitric_oxide synthase -LRB- NOS2 -RRB- activation in cultured rat cardiac myocytes and microvascular endothelial cells .
11847593	0	nitric_oxide	8,20	NOS2	38,42	nitric oxide	NOS2	MESH:D009569	18126(Tax:10090)	Chemical	Gene	type|amod|START_ENTITY type|appos|END_ENTITY	Lack of nitric_oxide synthase type 2 -LRB- NOS2 -RRB- results in reduced neuronal apoptosis and mortality following mouse_hepatitis_virus infection_of_the_central_nervous_system .
12097137	0	nitric_oxide	10,22	NOS2	33,37	nitric oxide	NOS2	MESH:D009569	4843	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Inducible nitric_oxide synthase -LRB- NOS2 -RRB- expressed in septic patients is nitrated on selected tyrosine residues : implications for enzymic activity .
12140750	0	nitric_oxide	60,72	NOS2	83,87	nitric oxide	NOS2	MESH:D009569	4843	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Genetic determinants of rheumatoid_arthritis : the inducible nitric_oxide synthase -LRB- NOS2 -RRB- gene promoter polymorphism .
12433515	0	nitric_oxide	59,71	NOS2	6,10	nitric oxide	NOS2	MESH:D009569	4843	Chemical	Gene	production|amod|START_ENTITY increased|dobj|production increased|nsubj|polymorphism polymorphism|compound|END_ENTITY	A new NOS2 promoter polymorphism associated with increased nitric_oxide production and protection from severe malaria in Tanzanian and Kenyan children .
14740870	0	nitric_oxide	10,22	NOS2	33,37	nitric oxide	NOS2	MESH:D009569	4843	Chemical	Gene	synthase|amod|START_ENTITY synthase|dep|END_ENTITY	Inducible nitric_oxide synthase -LRB- NOS2 -RRB- promoter CCTTT repeat polymorphism : relationship to in vivo nitric_oxide production/NOS activity in an asymptomatic malaria-endemic population .
14740870	0	nitric_oxide	99,111	NOS2	33,37	nitric oxide	NOS2	MESH:D009569	4843	Chemical	Gene	relationship|acl|START_ENTITY polymorphism|dep|relationship polymorphism|amod|synthase synthase|dep|END_ENTITY	Inducible nitric_oxide synthase -LRB- NOS2 -RRB- promoter CCTTT repeat polymorphism : relationship to in vivo nitric_oxide production/NOS activity in an asymptomatic malaria-endemic population .
16622021	0	nitric_oxide	8,20	NOS2	124,128	nitric oxide	NOS2	MESH:D009569	101823656	Chemical	Gene	activity|compound|START_ENTITY renders|nsubj|activity renders|xcomp|deficient deficient|nmod|activity activity|compound|END_ENTITY	Reduced nitric_oxide synthase 2 -LRB- NOS2 -RRB- promoter activity in the Syrian_hamster renders the animal functionally deficient in NOS2 activity and unable to control an intracellular pathogen .
16622021	0	nitric_oxide	8,20	NOS2	33,37	nitric oxide	NOS2	MESH:D009569	101823656	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Reduced nitric_oxide synthase 2 -LRB- NOS2 -RRB- promoter activity in the Syrian_hamster renders the animal functionally deficient in NOS2 activity and unable to control an intracellular pathogen .
17114245	0	nitric_oxide	12,24	NOS2	60,64	nitric oxide	NOS2	MESH:D009569	18126(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY decreases|nsubj|synthase decreases|ccomp|END_ENTITY	Endothelial nitric_oxide synthase -LRB- NOS3 -RRB- knockout decreases NOS2 induction , limiting hyperoxygenation and conferring protection in the postischemic heart .
17786214	0	nitric_oxide	20,32	NOS2	93,97	nitric oxide	NOS2	MESH:D009569	18126(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY Enhanced|dobj|production Enhanced|nmod|neocortex neocortex|nmod|mouse mouse|compound|END_ENTITY	Enhanced astrocytic nitric_oxide production and neuronal modifications in the neocortex of a NOS2 mutant mouse .
21481004	0	nitric_oxide	138,150	NOS2	109,113	nitric oxide	NOS2	MESH:D009569	4843	Chemical	Gene	synthase|amod|START_ENTITY inducible|dobj|synthase inducible|nsubj|Association Association|nmod|aphthous_stomatitis aphthous_stomatitis|nmod|polymorphism polymorphism|nmod|encoding encoding|compound|END_ENTITY	Association between recurrent aphthous_stomatitis and inheritance of a single-nucleotide polymorphism of the NOS2 gene encoding inducible nitric_oxide synthase .
22368302	0	nitric_oxide	87,99	NOS2	39,43	nitric oxide	NOS2	MESH:D009569	4843	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|polymorphisms polymorphisms|nmod|genes genes|compound|END_ENTITY	Single nucleotide polymorphisms in the NOS2 and NOS3 genes are associated with exhaled nitric_oxide .
24379293	0	nitric_oxide	47,59	NOS2	0,4	nitric oxide	NOS2	MESH:D009569	4843	Chemical	Gene	levels|amod|START_ENTITY control|nmod|levels reveal|dobj|control reveal|nsubj|variants variants|compound|END_ENTITY	NOS2 variants reveal a dual genetic control of nitric_oxide levels , susceptibility to Plasmodium infection , and cerebral_malaria .
7522210	0	nitric_oxide	62,74	NOS2	85,89	nitric oxide	NOS2	MESH:D009569	4843	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Mapping of the genes encoding human inducible and endothelial nitric_oxide synthase -LRB- NOS2 and NOS3 -RRB- to the pericentric region of chromosome 17 and to chromosome 7 , respectively .
7542877	0	nitric_oxide	65,77	NOS2	88,92	nitric oxide	NOS2	MESH:D009569	4843	Chemical	Gene	START_ENTITY|dobj|sequences sequences|appos|END_ENTITY	Molecular genetic analysis of the duplication of human inducible nitric_oxide synthase -LRB- NOS2 -RRB- sequences .
8645258	0	nitric_oxide	69,81	NOS2	97,101	nitric oxide	NOS2	MESH:D009569	4843	Chemical	Gene	START_ENTITY|dobj|gene gene|appos|END_ENTITY	Molecular cloning and structural organization of the human inducible nitric_oxide synthase gene -LRB- NOS2 -RRB- .
8840524	0	nitric_oxide	42,54	NOS2	65,69	nitric oxide	NOS2	MESH:D009569	18126(Tax:10090)	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	PCR-based gene targeting of the inducible nitric_oxide synthase -LRB- NOS2 -RRB- locus in murine ES cells , a new and more cost-effective approach .
9098436	0	nitric_oxide	22,34	NOS2	45,49	nitric oxide	NOS2	MESH:D009569	18126(Tax:10090)	Chemical	Gene	synthase|amod|START_ENTITY form|nmod|synthase form|appos|END_ENTITY	The inducible form of nitric_oxide synthase -LRB- NOS2 -RRB- isolated from murine macrophages maps near the nude mutation on mouse chromosome 11 .
9151890	0	nitric_oxide	104,116	NOS2	133,137	nitric oxide	NOS2	MESH:D009569	18126(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|iNOS iNOS|dep|END_ENTITY	Suppression of herpes_simplex_virus_type_1 _ -LRB- HSV-1 -RRB- - induced pneumonia in mice by inhibition of inducible nitric_oxide synthase -LRB- iNOS , NOS2 -RRB- .
12736741	0	nitric_oxide	28,40	NOS2A	57,62	nitric oxide	NOS2A	MESH:D009569	4843	Chemical	Gene	START_ENTITY|dobj|gene gene|appos|END_ENTITY	No association of inducible nitric_oxide synthase gene -LRB- NOS2A -RRB- to multiple_sclerosis .
10079196	0	nitric_oxide	14,26	NOS3	37,41	nitric oxide	NOS3	MESH:D009569	4846	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	Activation of nitric_oxide synthase -LRB- NOS3 -RRB- by mechanical activity alters contractile activity in a Ca2 + - independent manner in cardiac myocytes : role of troponin_I phosphorylation .
11745998	0	nitric_oxide	12,24	NOS3	40,44	nitric oxide	NOS3	MESH:D009569	4846	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Endothelial nitric_oxide synthase gene -LRB- NOS3 -RRB- variant and hypertension in pregnancy .
12136949	0	nitric_oxide	45,57	NOS3	73,77	nitric oxide	NOS3	MESH:D009569	4846	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphism in intron 23 of the endothelial nitric_oxide synthase gene -LRB- NOS3 -RRB- is not associated with hypertension .
12689917	0	nitric_oxide	22,34	NOS3	63,67	nitric oxide	NOS3	MESH:D009569	4846	Chemical	Gene	modulates|amod|START_ENTITY homocysteine|nsubj|modulates homocysteine|dobj|genotype genotype|compound|END_ENTITY	Genetic evidence that nitric_oxide modulates homocysteine : the NOS3 894TT genotype is a risk factor for hyperhomocystenemia .
12738608	0	nitric_oxide	65,77	NOS3	42,46	nitric oxide	NOS3	MESH:D009569	4846	Chemical	Gene	levels|compound|START_ENTITY Association|nmod|levels Association|nmod|mutation mutation|nmod|gene gene|compound|END_ENTITY	Association of a missense mutation in the NOS3 gene with exhaled nitric_oxide levels .
16269583	0	nitric_oxide	12,24	NOS3	35,39	nitric oxide	NOS3	MESH:D009569	4846	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Endothelial nitric_oxide synthase -LRB- NOS3 -RRB- genetic variants , maternal smoking , vitamin_use , and risk of human orofacial clefts .
17114245	0	nitric_oxide	12,24	NOS3	35,39	nitric oxide	NOS3	MESH:D009569	18127(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Endothelial nitric_oxide synthase -LRB- NOS3 -RRB- knockout decreases NOS2 induction , limiting hyperoxygenation and conferring protection in the postischemic heart .
17320763	0	nitric_oxide	26,38	NOS3	163,167	nitric oxide	NOS3	MESH:D009569	4846	Chemical	Gene	release|compound|START_ENTITY release|dep|pathways pathways|nmod|nitric_oxide_synthase nitric_oxide_synthase|appos|END_ENTITY	Vascular and perivascular nitric_oxide release and transport : biochemical pathways of neuronal nitric_oxide_synthase -LRB- NOS1 -RRB- and endothelial_nitric_oxide_synthase -LRB- NOS3 -RRB- .
17605790	0	nitric_oxide	40,52	NOS3	63,67	nitric oxide	NOS3	MESH:D009569	4846	Chemical	Gene	polymorphisms|amod|START_ENTITY polymorphisms|appos|END_ENTITY	Lack of association between endothelial nitric_oxide synthase -LRB- NOS3 -RRB- gene polymorphisms and suicide attempts .
17762636	0	nitric_oxide	18,30	NOS3	32,36	nitric oxide	NOS3	MESH:D009569	4846	Chemical	Gene	polymorphisms|amod|START_ENTITY polymorphisms|appos|END_ENTITY	Three endothelial nitric_oxide -LRB- NOS3 -RRB- gene polymorphisms in hypertensive and normotensive individuals : meta-analysis of 53 studies reveals evidence of publication bias .
18468205	0	nitric_oxide	120,132	NOS3	99,103	nitric oxide	NOS3	MESH:D009569	4846	Chemical	Gene	levels|compound|START_ENTITY gene|nmod|levels gene|appos|END_ENTITY	Lack of evidence for contribution of intron4a/b polymorphism of endothelial_nitric_oxide_synthase -LRB- NOS3 -RRB- gene to plasma nitric_oxide levels .
18941922	0	nitric_oxide	49,61	NOS3	77,81	nitric oxide	NOS3	MESH:D009569	4846	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association between polymorphisms of endothelial nitric_oxide synthase gene -LRB- NOS3 -RRB- and left_posterior_wall_thickness -LRB- LPWT -RRB- of the heart in Fabry_disease .
22051068	0	nitric_oxide	33,45	NOS3	56,60	nitric oxide	NOS3	MESH:D009569	4846	Chemical	Gene	synthase|amod|START_ENTITY gene|amod|synthase gene|appos|END_ENTITY	Polymorphisms of the endothelial nitric_oxide synthase -LRB- NOS3 -RRB- gene in preeclampsia : a candidate-gene association study .
24684492	0	nitric_oxide	15,27	NOS3	40,44	nitric oxide	NOS3	MESH:D009569	4846	Chemical	Gene	synthase|compound|START_ENTITY Association|nmod|synthase Association|appos|END_ENTITY	Association of nitric_oxide synthase 3 -LRB- NOS3 -RRB- 894 __ G > T polymorphism with prognostic outcomes of anthracycline in Chinese patients with acute_myeloid_leukaemia .
25061098	2	nitric_oxide	118,130	NOS3	140,144	nitric oxide	NOS3	MESH:D009569	4846	Chemical	Gene	mRNA|amod|START_ENTITY mRNA|compound|END_ENTITY	Consequences of loss of function of nitric_oxide synthase NOS3 mRNA in ovine conceptus trophectoderm .
25239655	0	nitric_oxide	54,66	NOS3	13,17	nitric oxide	NOS3	MESH:D009569	4846	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|amod|E298D E298D|compound|END_ENTITY	Endothelial -LRB- NOS3 E298D -RRB- and inducible -LRB- NOS2 exon 22 -RRB- nitric_oxide synthase polymorphisms , as well as plasma NOx , influence sepsis development .
26428312	0	nitric_oxide	12,24	NOS3	100,104	nitric oxide	NOS3	MESH:D009569	4846	Chemical	Gene	synthase|nsubj|START_ENTITY synthase|nmod|implications implications|nmod|polymorphisms polymorphisms|nummod|END_ENTITY	Endothelial nitric_oxide synthase : From biochemistry and gene structure to clinical implications of NOS3 polymorphisms .
12673515	0	nitric_oxide	33,45	NOS_I_and_III	56,69	nitric oxide	NOS I and III	MESH:D009569	4846	Chemical	Gene	synthase|amod|START_ENTITY localization|nmod|synthase localization|appos|END_ENTITY	-LSB- Ultrastructural localization of nitric_oxide synthase -LRB- NOS_I_and_III -RRB- in human nasal mucosa -RSB- .
10465511	0	nitric_oxide	41,53	NPY	27,30	nitric oxide	NPY	MESH:D009569	109648(Tax:10090)	Chemical	Gene	synthase|amod|START_ENTITY modulate|dobj|synthase modulate|nsubj|Leptin Leptin|appos|END_ENTITY	Leptin and neuropeptide_Y -LRB- NPY -RRB- modulate nitric_oxide synthase : further evidence for a role of nitric_oxide in feeding .
10465511	0	nitric_oxide	95,107	NPY	27,30	nitric oxide	NPY	MESH:D009569	109648(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY evidence|nmod|role synthase|dep|evidence modulate|dobj|synthase modulate|nsubj|Leptin Leptin|appos|END_ENTITY	Leptin and neuropeptide_Y -LRB- NPY -RRB- modulate nitric_oxide synthase : further evidence for a role of nitric_oxide in feeding .
19245788	0	nitric_oxide	56,68	NPY	27,30	nitric oxide	NPY	MESH:D009569	4852	Chemical	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	The role of non-synonymous NPY gene polymorphism in the nitric_oxide production in HUVECs .
11108935	1	nitric_oxide	76,88	NT-3	103,107	nitric oxide	NT-3	MESH:D009569	18205(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY Regulation|nmod|production Regulation|nmod|END_ENTITY	Regulation of nitric_oxide production by NT-3 .
9724806	0	nitric_oxide	75,87	Nerve_growth_factor	0,19	nitric oxide	Nerve growth factor	MESH:D009569	310738(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY suppresses|dobj|activity suppresses|nsubj|END_ENTITY	Nerve_growth_factor rapidly suppresses basal , NMDA-evoked , and AMPA-evoked nitric_oxide synthase activity in rat hippocampus in vivo .
16563502	0	nitric_oxide	21,33	Neurotensin	0,11	nitric oxide	Neurotensin	MESH:D009569	67405(Tax:10090)	Chemical	Gene	generation|amod|START_ENTITY enhances|dobj|generation enhances|nsubj|END_ENTITY	Neurotensin enhances nitric_oxide generation via the JAK2-STAT1 pathway in murine macrophage Raw264 .7 cells during costimulation with LPS and IFNgamma .
18093296	0	nitric_oxide	10,22	Nos2	33,37	nitric oxide	Nos2	MESH:D009569	18126(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Inducible nitric_oxide synthase , Nos2 , does not mediate optic_neuropathy and retinopathy in the DBA/2J glaucoma model .
9460080	0	nitric_oxide	21,33	Nos2	131,135	nitric oxide	Nos2	MESH:D009569	24599(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY transcriptional|nsubj|production transcriptional|dobj|activation activation|nmod|END_ENTITY	Homocysteine-induced nitric_oxide production in vascular smooth-muscle cells by NF-kappa B-dependent transcriptional activation of Nos2 .
22217881	0	nitric_oxide	96,108	Nox4	77,81	nitric oxide	Nox4	MESH:D009569	50507	Chemical	Gene	synthase|compound|START_ENTITY synthase|amod|END_ENTITY	Aspirin inhibits the production of reactive oxygen species by downregulating Nox4 and inducible nitric_oxide synthase in human endothelial cells exposed to oxidized low-density lipoprotein .
19467240	0	nitric_oxide	91,103	Oct-1	15,20	nitric oxide	Oct-1	MESH:D009569	5451	Chemical	Gene	gene|compound|START_ENTITY transcription|nmod|gene regulates|dobj|transcription regulates|nsubj|motif motif|compound|END_ENTITY	A far-upstream Oct-1 motif regulates cytokine-induced transcription of the human inducible nitric_oxide synthase gene .
11134960	0	nitric_oxide	111,123	Octamer_binding_protein-1	0,25	nitric oxide	Octamer binding protein-1	MESH:D009569	18986(Tax:10090)	Chemical	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	Octamer_binding_protein-1 is involved in inhibition of inducible_nitric_oxide_synthase expression by exogenous nitric_oxide in murine liver cells .
11522631	0	nitric_oxide	78,90	Ogg1	6,10	nitric oxide	Ogg1	MESH:D009569	4968	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|END_ENTITY	Human Ogg1 , a protein involved in the repair of 8-oxoguanine , is inhibited by nitric_oxide .
10868913	0	nitric_oxide	26,38	Osteopontin	0,11	nitric oxide	Osteopontin	MESH:D009569	20750(Tax:10090)	Chemical	Gene	cells|amod|START_ENTITY induced|nmod|cells induced|nsubjpass|END_ENTITY	Osteopontin is induced by nitric_oxide in RAW 264.7 cells .
11145688	0	nitric_oxide	48,60	Osteopontin	0,11	nitric oxide	Osteopontin	MESH:D009569	20750(Tax:10090)	Chemical	Gene	synthesis|amod|START_ENTITY regulator|nmod|synthesis regulator|nsubj|END_ENTITY	Osteopontin is a negative feedback regulator of nitric_oxide synthesis in murine macrophages .
16904962	0	nitric_oxide	32,44	Osteopontin	0,11	nitric oxide	Osteopontin	MESH:D009569	20750(Tax:10090)	Chemical	Gene	synthesis|amod|START_ENTITY inhibits|dobj|synthesis inhibits|nsubj|END_ENTITY	Osteopontin inhibits macrophage nitric_oxide synthesis to enhance tumor proliferation .
20497690	0	nitric_oxide	73,85	Osteopontin	0,11	nitric oxide	Osteopontin	MESH:D009569	20750(Tax:10090)	Chemical	Gene	synthases|amod|START_ENTITY inhibiting|dobj|synthases protects|advcl|inhibiting protects|nsubj|END_ENTITY	Osteopontin protects against hyperoxia-induced lung_injury by inhibiting nitric_oxide synthases .
7506262	0	nitric_oxide	34,46	Osteopontin	0,11	nitric oxide	Osteopontin	MESH:D009569	20750(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY induction|nmod|expression inhibits|dobj|induction inhibits|nsubj|END_ENTITY	Osteopontin inhibits induction of nitric_oxide synthase gene expression by inflammatory mediators in mouse kidney epithelial cells .
8830797	0	nitric_oxide	21,33	Osteopontin	0,11	nitric oxide	Osteopontin	MESH:D009569	20750(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Osteopontin inhibits nitric_oxide production and cytotoxicity by activated RAW264 .7 macrophages .
15373757	0	nitric_oxide	19,31	Oxytocin	0,8	nitric oxide	Oxytocin	MESH:D009569	5020	Chemical	Gene	generation|amod|START_ENTITY modulates|dobj|generation modulates|nsubj|END_ENTITY	Oxytocin modulates nitric_oxide generation by human fetal membranes at term pregnancy .
23183119	0	nitric_oxide	17,29	Oxytocin	0,8	nitric oxide	Oxytocin	MESH:D009569	25504(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY affects|dobj|production affects|nsubj|END_ENTITY	Oxytocin affects nitric_oxide and cytokine production by sepsis-sensitized macrophages .
24920283	0	nitric_oxide	75,87	Oxytocin	0,8	nitric oxide	Oxytocin	MESH:D009569	5020	Chemical	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Oxytocin , its antagonist Atosiban , and preterm_labor : a role for placental nitric_oxide .
10822898	0	nitric_oxide	99,111	P-selectin	28,38	nitric oxide	P-selectin	MESH:D009569	6403	Chemical	Gene	role|nmod|START_ENTITY reduces|parataxis|role reduces|dobj|levels levels|amod|END_ENTITY	Fluvastatin reduces soluble P-selectin and ICAM-1 levels in hypercholesterolemic patients : role of nitric_oxide .
11886397	0	nitric_oxide	10,22	P-selectin	98,108	nitric oxide	P-selectin	MESH:D009569	6403	Chemical	Gene	modulation|amod|START_ENTITY Effect|nmod|modulation determined|nsubj|Effect determined|nmod|expression expression|amod|END_ENTITY	Effect of nitric_oxide modulation on systemic haemodynamics and platelet activation determined by P-selectin expression .
7583591	0	nitric_oxide	14,26	P-selectin	49,59	nitric oxide	P-selectin	MESH:D009569	6403	Chemical	Gene	biosynthesis|amod|START_ENTITY Inhibition|nmod|biosynthesis promotes|nsubj|Inhibition promotes|dobj|expression expression|amod|END_ENTITY	Inhibition of nitric_oxide biosynthesis promotes P-selectin expression in platelets .
9277491	0	nitric_oxide	66,78	P-selectin	14,24	nitric oxide	P-selectin	MESH:D009569	6403	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of P-selectin expression in human endothelial cells by nitric_oxide .
9788825	0	nitric_oxide	142,154	P-selectin	24,34	nitric oxide	P-selectin	MESH:D009569	6403	Chemical	Gene	role|nmod|START_ENTITY factor|dep|role factor|nsubj|expression expression|nmod|END_ENTITY	Increased expression of P-selectin on platelets is a risk factor for silent cerebral_infarction in patients with atrial_fibrillation : role of nitric_oxide .
8864115	0	nitric_oxide	49,61	PIN	0,3	nitric oxide	PIN	MESH:D009569	58945(Tax:10116)	Chemical	Gene	synthase|compound|START_ENTITY inhibitor|nmod|synthase END_ENTITY|dep|inhibitor	PIN : an associated protein inhibitor of neuronal nitric_oxide synthase .
9651483	0	nitric_oxide	64,76	PIN	87,90	nitric oxide	PIN	MESH:D009569	100008650(Tax:9986)	Chemical	Gene	START_ENTITY|dobj|gene gene|appos|END_ENTITY	Cloning and structure of a rabbit protein inhibitor of neuronal nitric_oxide synthase -LRB- PIN -RRB- gene and its pseudogene .
9688579	0	nitric_oxide	102,114	PIN	57,60	nitric oxide	PIN	MESH:D009569	8655	Chemical	Gene	synthases|compound|START_ENTITY action|nmod|synthases characterization|nmod|action inhibitor|dep|characterization inhibitor|nmod|synthase synthase|appos|END_ENTITY	The protein inhibitor of neuronal nitric_oxide synthase -LRB- PIN -RRB- : characterization of its action on pure nitric_oxide synthases .
9688579	0	nitric_oxide	34,46	PIN	57,60	nitric oxide	PIN	MESH:D009569	8655	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	The protein inhibitor of neuronal nitric_oxide synthase -LRB- PIN -RRB- : characterization of its action on pure nitric_oxide synthases .
9808772	0	nitric_oxide	48,60	PIN	31,34	nitric oxide	PIN	MESH:D009569	58945(Tax:10116)	Chemical	Gene	chain|nmod|START_ENTITY chain|appos|END_ENTITY	Binding of dynein light chain -LRB- PIN -RRB- to neuronal nitric_oxide synthase in the absence of inhibition .
19564638	0	nitric_oxide	31,43	PKC_zeta	65,73	nitric oxide	PKC zeta	MESH:D009569	5590	Chemical	Gene	synthase|compound|START_ENTITY synthase|nmod|END_ENTITY	Phosphorylation of endothelial nitric_oxide synthase by atypical PKC_zeta contributes to angiopoietin-1-dependent inhibition of VEGF-induced endothelial permeability in vitro .
10364559	0	nitric_oxide	49,61	PSD-95	79,85	nitric oxide	PSD-95	MESH:D009569	1742	Chemical	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	Specific coupling of NMDA receptor activation to nitric_oxide neurotoxicity by PSD-95 protein .
20055753	0	nitric_oxide	22,34	PTP-alpha	113,122	nitric oxide	PTP-alpha	MESH:D009569	19262(Tax:10090)	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Regulatory effects of nitric_oxide on Src kinase , FAK , p130Cas , and receptor protein tyrosine phosphatase alpha -LRB- PTP-alpha -RRB- : a role for the cellular redox environment .
17698736	0	nitric_oxide	70,82	PYK2	50,54	nitric oxide	PYK2	MESH:D009569	19229(Tax:10090)	Chemical	Gene	response|amod|START_ENTITY END_ENTITY|nmod|response	Central role of calcium-dependent tyrosine kinase PYK2 in endothelial nitric_oxide synthase-mediated angiogenic response and vascular function .
8447474	0	nitric_oxide	33,45	Plasmin	0,7	nitric oxide	Plasmin	MESH:D009569	5340	Chemical	Gene	synthesis|amod|START_ENTITY induction|nmod|synthesis potentiates|dobj|induction potentiates|nsubj|END_ENTITY	Plasmin potentiates induction of nitric_oxide synthesis by interleukin-1_beta in vascular smooth muscle cells .
10582584	0	nitric_oxide	23,35	Prolactin	0,9	nitric oxide	Prolactin	MESH:D009569	24683(Tax:10116)	Chemical	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	Prolactin induction of nitric_oxide synthase in rat C6 glioma cells .
20943859	0	nitric_oxide	75,87	Prolactin	0,9	nitric oxide	Prolactin	MESH:D009569	24683(Tax:10116)	Chemical	Gene	synthase|compound|START_ENTITY activating|dobj|synthase promotes|advcl|activating promotes|nsubj|END_ENTITY	Prolactin promotes oxytocin and vasopressin release by activating neuronal nitric_oxide synthase in the supraoptic and paraventricular nuclei .
14730623	0	nitric_oxide	99,111	Proline-rich_tyrosine_kinase_2	0,30	nitric oxide	Proline-rich tyrosine kinase 2	MESH:D009569	2185	Chemical	Gene	production|compound|START_ENTITY signaling|dobj|production kinase|xcomp|signaling kinase|nsubj|END_ENTITY	Proline-rich_tyrosine_kinase_2 and Src kinase signaling transduce monosodium_urate crystal-induced nitric_oxide production and matrix_metalloproteinase_3 expression in chondrocytes .
15033389	0	nitric_oxide	67,79	Protein_kinase_A	0,16	nitric oxide	Protein kinase A	MESH:D009569	25636(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY increases|dobj|release increases|nsubj|END_ENTITY	Protein_kinase_A increases electrical stimulation-induced neuronal nitric_oxide release in rat mesenteric artery .
15931667	0	nitric_oxide	69,81	Rap1	15,19	nitric oxide	Rap1	MESH:D009569	109905(Tax:10090)	Chemical	Gene	production|nmod|START_ENTITY required|nmod|production required|nsubjpass|activation activation|amod|END_ENTITY	Epac1-mediated Rap1 activation is not required for the production of nitric_oxide in BV2 , murine microglial cells .
7508926	0	nitric_oxide	60,72	Rel	40,43	nitric oxide	Rel	MESH:D009569	19696(Tax:10090)	Chemical	Gene	synthase|amod|START_ENTITY END_ENTITY|nmod|synthase	Role of transcription factor NF-kappa_B / Rel in induction of nitric_oxide synthase .
10893643	0	nitric_oxide	73,85	Renin	0,5	nitric oxide	Renin	MESH:D009569	100358545(Tax:9986)	Chemical	Gene	interaction|nmod|START_ENTITY system|dep|interaction system|compound|END_ENTITY	Renin angiotensin system of rabbit clitoral cavernosum : interaction with nitric_oxide .
18645051	0	nitric_oxide	44,56	Renin	0,5	nitric oxide	Renin	MESH:D009569	100358545(Tax:9986)	Chemical	Gene	improves|dobj|START_ENTITY improves|nsubj|aliskiren aliskiren|compound|END_ENTITY	Renin inhibitor aliskiren improves impaired nitric_oxide bioavailability and protects against atherosclerotic changes .
8024020	0	nitric_oxide	41,53	Renin	0,5	nitric oxide	Renin	MESH:D009569	24715(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY blockade|nmod|synthesis release|nmod|blockade release|nsubj|END_ENTITY	Renin release in rats during blockade of nitric_oxide synthesis .
12524425	0	nitric_oxide	33,45	RhoA	0,4	nitric oxide	RhoA	MESH:D009569	387	Chemical	Gene	controlled|nmod|START_ENTITY controlled|nsubjpass|expression expression|compound|END_ENTITY	RhoA expression is controlled by nitric_oxide through cGMP-dependent_protein_kinase activation .
14572607	0	nitric_oxide	55,67	Rho_A	0,5	nitric oxide	Rho A	MESH:D009569	387	Chemical	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Rho_A negatively regulates cytokine-mediated inducible nitric_oxide synthase expression in brain-derived transformed cell lines : negative regulation of IKKalpha .
9021952	0	nitric_oxide	85,97	S-adenosylmethionine_synthetase	24,55	nitric oxide	S-adenosylmethionine synthetase	MESH:D009569	25331(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY Regulation|dep|role Regulation|nmod|END_ENTITY	Regulation of rat liver S-adenosylmethionine_synthetase during septic shock : role of nitric_oxide .
17678654	0	nitric_oxide	47,59	S100B	22,27	nitric oxide	S100B	MESH:D009569	6285	Chemical	Gene	START_ENTITY|nsubj|stimulates stimulates|compound|END_ENTITY	Enteric glial-derived S100B protein stimulates nitric_oxide production in celiac_disease .
19558426	0	nitric_oxide	18,30	S100B	111,116	nitric oxide	S100B	MESH:D009569	6285	Chemical	Gene	production|compound|START_ENTITY mediated|nsubjpass|production mediated|nmod|protein protein|compound|END_ENTITY	Increased mucosal nitric_oxide production in ulcerative_colitis is mediated in part by the enteroglial-derived S100B protein .
20862685	0	nitric_oxide	99,111	SET-1A	36,42	nitric oxide	SET-1A	MESH:D009569	9739	Chemical	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Contribution of H3K4 methylation by SET-1A to interleukin-1-induced cyclooxygenase_2 and inducible nitric_oxide synthase expression in human osteoarthritis chondrocytes .
15843443	0	nitric_oxide	16,28	SGK1	8,12	nitric oxide	SGK1	MESH:D009569	20393(Tax:10090)	Chemical	Gene	inhibition|amod|START_ENTITY END_ENTITY|nmod|inhibition	Role of SGK1 in nitric_oxide inhibition of ENaC in Na + - transporting epithelia .
23174672	0	nitric_oxide	61,73	SIN-1	47,52	nitric oxide	SIN-1	MESH:D009569	79109	Chemical	Gene	generation|compound|START_ENTITY generation|compound|END_ENTITY	Neuroprotective effects of Cyperus rotundus on SIN-1 induced nitric_oxide generation and protein nitration : ameliorative effect against apoptosis mediated neuronal cell damage .
17869187	0	nitric_oxide	30,42	SK3	78,81	nitric oxide	SK3	MESH:D009569	140493(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Down-regulation of endogenous nitric_oxide synthase inhibitors on endothelial SK3 expression .
20418387	0	nitric_oxide	54,66	SP-B	30,34	nitric oxide	SP-B	MESH:D009569	20388(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Transcriptional regulation of SP-B gene expression by nitric_oxide in H441 lung epithelial cells .
19754268	0	nitric_oxide	21,33	STAT3	121,126	nitric oxide	STAT3	MESH:D009569	100294659(Tax:9940)	Chemical	Gene	START_ENTITY|xcomp|signaling signaling|nmod|activation activation|nmod|END_ENTITY	Endothelin-1 impairs nitric_oxide signaling in endothelial cells through a protein_kinase_Cdelta-dependent activation of STAT3 and decreased endothelial_nitric_oxide_synthase expression .
15652699	0	nitric_oxide	39,51	Soluble_guanylate_cyclase	0,25	nitric oxide	Soluble guanylate cyclase	MESH:D009569	25206(Tax:10116)	Chemical	Gene	colocalize|amod|START_ENTITY colocalize|amod|END_ENTITY	Soluble_guanylate_cyclase and neuronal nitric_oxide synthase colocalize in rat nucleus tractus solitarii .
11752210	0	nitric_oxide	73,85	Soluble_guanylyl_cyclase	0,24	nitric oxide	Soluble guanylyl cyclase	MESH:D009569	25206(Tax:10116)	Chemical	Gene	toxicity|amod|START_ENTITY protects|nmod|toxicity protects|nsubj|YC-1 YC-1|amod|END_ENTITY	Soluble_guanylyl_cyclase activator YC-1 protects white matter axons from nitric_oxide toxicity and metabolic stress , probably through Na -LRB- + -RRB- _ channel inhibition .
9000434	0	nitric_oxide	89,101	Somatostatin	0,12	nitric oxide	Somatostatin	MESH:D009569	6750	Chemical	Gene	artery|nmod|START_ENTITY induces|nmod|artery induces|nsubj|END_ENTITY	Somatostatin induces vasodilatation in the cat mesenteric artery via endothelium-derived nitric_oxide and prostaglandins .
20055753	0	nitric_oxide	22,34	Src	38,41	nitric oxide	Src	MESH:D009569	20779(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|kinase kinase|compound|END_ENTITY	Regulatory effects of nitric_oxide on Src kinase , FAK , p130Cas , and receptor protein tyrosine phosphatase alpha -LRB- PTP-alpha -RRB- : a role for the cellular redox environment .
10428650	0	nitric_oxide	21,33	Substance_P	0,11	nitric oxide	Substance P	MESH:D009569	21333(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|augments augments|amod|END_ENTITY	Substance_P augments nitric_oxide production and gene expression in murine macrophages .
16186752	0	nitric_oxide	24,36	Substance_P	44,55	nitric oxide	Substance P	MESH:D009569	281512(Tax:9913)	Chemical	Gene	START_ENTITY|nmod|vasodilation vasodilation|compound|END_ENTITY	The role of endothelial nitric_oxide in the Substance_P induced vasodilation in bovine dental pulp .
18952239	0	nitric_oxide	38,50	Substance_P	0,11	nitric oxide	Substance P	MESH:D009569	21333(Tax:10090)	Chemical	Gene	mice|amod|START_ENTITY closure|nmod|mice enhances|dobj|closure enhances|nsubj|END_ENTITY	Substance_P enhances wound closure in nitric_oxide synthase knockout mice .
21212274	0	nitric_oxide	19,31	TAp73	0,5	nitric oxide	TAp73	MESH:D009569	22062(Tax:10090)	Chemical	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	TAp73 induction by nitric_oxide : regulation by checkpoint_kinase_1 -LRB- CHK1 -RRB- and protection against apoptosis .
9737674	0	nitric_oxide	45,57	TGF-beta	104,112	nitric oxide	TGF-beta	MESH:D009569	7040	Chemical	Gene	synthase|amod|START_ENTITY localization|nmod|synthase localization|appos|END_ENTITY	Immunocytochemical localization of inducible nitric_oxide synthase and transforming_growth_factor-beta -LRB- TGF-beta -RRB- in leprosy_lesions .
17941092	0	nitric_oxide	77,89	TGF-beta1	14,23	nitric oxide	TGF-beta1	MESH:D009569	7040	Chemical	Gene	transcription|nmod|START_ENTITY transcription|nsubj|Regulation Regulation|nmod|gene gene|compound|END_ENTITY	Regulation of TGF-beta1 gene transcription in human prostate_cancer cells by nitric_oxide .
8773588	0	nitric_oxide	11,23	TGF-beta1	49,58	nitric oxide	TGF-beta1	MESH:D009569	21803(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY Control|nmod|production Control|nmod|END_ENTITY	Control of nitric_oxide production by endogenous TGF-beta1 and systemic nitric_oxide in retinal pigment epithelial cells and peritoneal macrophages .
10929071	0	nitric_oxide	126,138	THP-1	75,80	nitric oxide	THP-1	MESH:D009569	2736	Chemical	Gene	synthase|compound|START_ENTITY expression|nmod|synthase stimulates|dobj|expression stimulates|nsubj|Dimerization Dimerization|nmod|I I|nmod|surface surface|nmod|cells cells|compound|END_ENTITY	Dimerization of major histocompatibility complex class I on the surface of THP-1 cells stimulates the expression of inducible nitric_oxide synthase and subsequent nitric_oxide release .
11226385	0	nitric_oxide	62,74	THP-1	91,96	nitric oxide	THP-1	MESH:D009569	2736	Chemical	Gene	START_ENTITY|nmod|macrophages macrophages|appos|END_ENTITY	Inhibition by ginkgolides and bilobalide of the production of nitric_oxide in macrophages -LRB- THP-1 -RRB- but not in endothelial cells -LRB- HUVEC -RRB- .
26826317	0	nitric_oxide	12,24	THP-1	57,62	nitric oxide	THP-1	MESH:D009569	2736	Chemical	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	The role of nitric_oxide in the epigenetic regulation of THP-1 induced by lipopolysaccharide .
21744329	0	nitric_oxide	28,40	TNF	80,83	nitric oxide	TNF	MESH:D009569	7124	Chemical	Gene	START_ENTITY|appos|IL-13 IL-13|dep|END_ENTITY	Assessment of the levels of nitric_oxide -LRB- NO -RRB- and cytokines -LRB- IL-5 , IL-6 , IL-13 , TNF , IFN-gamma -RRB- in giardiosis .
21353543	0	nitric_oxide	99,111	TNF-a	129,134	nitric oxide	TNF-a	MESH:D009569	21926(Tax:10090)	Chemical	Gene	production|nmod|START_ENTITY production|nmod|END_ENTITY	A new ursane-type triterpenoid_glycoside from Centella asiatica leaves modulates the production of nitric_oxide and secretion of TNF-a in activated RAW 264.7 cells .
10415049	0	nitric_oxide	62,74	TNF-alpha	152,161	nitric oxide	TNF-alpha	MESH:D009569	7124	Chemical	Gene	protects|nsubj|START_ENTITY protects|advcl|regulating regulating|dobj|expression expression|nmod|END_ENTITY	Human NK cells express endothelial_nitric_oxide_synthase , and nitric_oxide protects them from activation-induced cell death by regulating expression of TNF-alpha .
10718379	0	nitric_oxide	19,31	TNF-alpha	35,44	nitric oxide	TNF-alpha	MESH:D009569	24835(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|generation generation|amod|END_ENTITY	Role of endogenous nitric_oxide in TNF-alpha and IL-1beta generation in hepatic_ischemia-repefusion .
10986217	0	nitric_oxide	44,56	TNF-alpha	0,9	nitric oxide	TNF-alpha	MESH:D009569	24835(Tax:10116)	Chemical	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	TNF-alpha dependent production of inducible nitric_oxide is involved in PGE -LRB- 1 -RRB- protection against acute_liver_injury .
11167545	0	nitric_oxide	25,37	TNF-alpha	109,118	nitric oxide	TNF-alpha	MESH:D009569	7124	Chemical	Gene	inhibitor|amod|START_ENTITY administration|nmod|inhibitor enhances|nsubj|administration enhances|dobj|angiogenesis angiogenesis|acl|mediated mediated|nmod|secretion secretion|amod|END_ENTITY	Oral administration of a nitric_oxide synthase inhibitor enhances de novo mammalian angiogenesis mediated by TNF-alpha , saline and mast-cell secretion .
11266388	0	nitric_oxide	31,43	TNF-alpha	87,96	nitric oxide	TNF-alpha	MESH:D009569	21926(Tax:10090)	Chemical	Gene	synthase|amod|START_ENTITY inducible|dobj|synthase inducible|advcl|protect protect|nmod|END_ENTITY	NF-kappaB stimulates inducible nitric_oxide synthase to protect mouse hepatocytes from TNF-alpha - and Fas-mediated apoptosis .
11359829	0	nitric_oxide	72,84	TNF-alpha	0,9	nitric oxide	TNF-alpha	MESH:D009569	21926(Tax:10090)	Chemical	Gene	synthase-dependent|compound|START_ENTITY intracellular|nmod|synthase-dependent intracellular|nsubj|controls controls|amod|END_ENTITY	TNF-alpha controls intracellular mycobacterial growth by both inducible nitric_oxide synthase-dependent and inducible nitric_oxide synthase-independent pathways .
11481030	0	nitric_oxide	92,104	TNF-alpha	0,9	nitric oxide	TNF-alpha	MESH:D009569	7124	Chemical	Gene	regulated|parataxis|START_ENTITY regulated|nsubjpass|expression expression|compound|END_ENTITY	TNF-alpha induced endothelial MAdCAM-1 expression is regulated by exogenous , not endogenous nitric_oxide .
11790511	0	nitric_oxide	85,97	TNF-alpha	16,25	nitric oxide	TNF-alpha	MESH:D009569	24835(Tax:10116)	Chemical	Gene	expression|compound|START_ENTITY implicated|nmod|expression implicated|nsubjpass|increase increase|nmod|levels levels|amod|END_ENTITY	The increase in TNF-alpha levels is implicated in NF-kappaB activation and inducible nitric_oxide synthase expression in brain cortex after immobilization stress .
12884305	0	nitric_oxide	36,48	TNF-alpha	0,9	nitric oxide	TNF-alpha	MESH:D009569	21926(Tax:10090)	Chemical	Gene	synthase|amod|START_ENTITY induction|nmod|synthase mediates|dobj|induction mediates|nsubj|END_ENTITY	TNF-alpha mediates the induction of nitric_oxide synthase in macrophages but not in neutrophils in experimental cutaneous leishmaniasis .
12907844	0	nitric_oxide	27,39	TNF-alpha	135,144	nitric oxide	TNF-alpha	MESH:D009569	24835(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY Inhibition|nmod|production increases|nsubj|Inhibition increases|dobj|severity severity|dep|role role|nmod|END_ENTITY	Inhibition of constitutive nitric_oxide production increases the severity of lipopolysaccharide-induced sickness_behaviour : a role for TNF-alpha .
14735448	0	nitric_oxide	59,71	TNF-alpha	110,119	nitric oxide	TNF-alpha	MESH:D009569	21926(Tax:10090)	Chemical	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Tanshinone_IIA from Salvia miltiorrhiza inhibits inducible nitric_oxide synthase expression and production of TNF-alpha , IL-1beta and IL-6 in activated RAW 264.7 cells .
15222978	0	nitric_oxide	97,109	TNF-alpha	127,136	nitric oxide	TNF-alpha	MESH:D009569	21926(Tax:10090)	Chemical	Gene	production|nmod|START_ENTITY production|nmod|END_ENTITY	Platycodin_D and D3 isolated from the root of Platycodon grandiflorum modulate the production of nitric_oxide and secretion of TNF-alpha in activated RAW 264.7 cells .
17101606	0	nitric_oxide	14,26	TNF-alpha	71,80	nitric oxide	TNF-alpha	MESH:D009569	21926(Tax:10090)	Chemical	Gene	synthesis|amod|START_ENTITY Regulation|nmod|synthesis depends|nsubj|Regulation depends|nmod|END_ENTITY	Regulation of nitric_oxide synthesis in wounds by IFN-gamma depends on TNF-alpha .
17133313	0	nitric_oxide	53,65	TNF-alpha	89,98	nitric oxide	TNF-alpha	MESH:D009569	7124	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	The effect of weight_loss on serum concentrations of nitric_oxide , TNF-alpha and soluble TNF-alpha receptors .
17374495	0	nitric_oxide	74,86	TNF-alpha	102,111	nitric oxide	TNF-alpha	MESH:D009569	7124	Chemical	Gene	START_ENTITY|nmod|cells cells|amod|END_ENTITY	Regulation of NF-kappaB activation and nuclear translocation by exogenous nitric_oxide -LRB- NO -RRB- donors in TNF-alpha activated vascular endothelial cells .
18293202	0	nitric_oxide	17,29	TNF-alpha	0,9	nitric oxide	TNF-alpha	MESH:D009569	7124	Chemical	Gene	vasodilatation|amod|START_ENTITY alters|dobj|vasodilatation alters|nsubj|END_ENTITY	TNF-alpha alters nitric_oxide - and endothelium-derived hyperpolarizing factor-mediated vasodilatation in human omental arteries .
18983746	0	nitric_oxide	60,72	TNF-alpha	0,9	nitric oxide	TNF-alpha	MESH:D009569	7124	Chemical	Gene	production|amod|START_ENTITY elevating|dobj|production affect|advcl|elevating affect|nsubj|END_ENTITY	TNF-alpha and IL-6 affect human sperm function by elevating nitric_oxide production .
19539031	0	nitric_oxide	42,54	TNF-alpha	93,102	nitric oxide	TNF-alpha	MESH:D009569	21926(Tax:10090)	Chemical	Gene	production|nmod|START_ENTITY analysis|nmod|production necrosis|nsubj|analysis necrosis|dep|END_ENTITY	Comparative analysis of the production of nitric_oxide -LRB- NO -RRB- and tumor necrosis factor-alpha -LRB- TNF-alpha -RRB- from macrophages exposed to high virulent and low virulent strains of Edwardsiella_tarda .
21166155	0	nitric_oxide	34,46	TNF-alpha	84,93	nitric oxide	TNF-alpha	MESH:D009569	24835(Tax:10116)	Chemical	Gene	channels|amod|START_ENTITY channels|nmod|cardioprotection cardioprotection|amod|END_ENTITY	-LSB- Role of reactive oxygen species , nitric_oxide and mitochondrial K -LRB- ATP -RRB- channels in TNF-alpha induced cardioprotection -RSB- .
7512527	0	nitric_oxide	26,38	TNF-alpha	108,117	nitric oxide	TNF-alpha	MESH:D009569	21926(Tax:10090)	Chemical	Gene	synthase|amod|START_ENTITY induction|nmod|synthase induction|dep|role role|nmod|END_ENTITY	Differential induction of nitric_oxide synthase in various organs of the mouse during endotoxaemia : role of TNF-alpha and IL-1-beta .
7544321	0	nitric_oxide	164,176	TNF-alpha	109,118	nitric oxide	TNF-alpha	MESH:D009569	21926(Tax:10090)	Chemical	Gene	synthase|amod|START_ENTITY induction|nmod|synthase promote|nmod|induction promote|dobj|synthesis synthesis|nmod|END_ENTITY	Tumor-derived factor synergizes with IFN-gamma and LPS , IL-2 or TNF-alpha to promote macrophage synthesis of TNF-alpha and TNF_receptors for autocrine induction of nitric_oxide synthase and enhanced nitric_oxide-mediated tumor_cytotoxicity .
7544539	0	nitric_oxide	45,57	TNF-alpha	0,9	nitric oxide	TNF-alpha	MESH:D009569	24835(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY expression|nmod|synthase induce|dobj|expression induce|nsubj|END_ENTITY	TNF-alpha and IFN-gamma induce expression of nitric_oxide synthase in cultured rat medullary interstitial cells .
7948748	0	nitric_oxide	124,136	TNF-alpha	0,9	nitric oxide	TNF-alpha	MESH:D009569	21926(Tax:10090)	Chemical	Gene	generation|nmod|START_ENTITY islets|nmod|generation effects|nmod|islets potentiate|dobj|effects potentiate|nsubj|END_ENTITY	TNF-alpha and IFN-gamma potentiate the deleterious effects of IL-1_beta on mouse pancreatic islets mainly via generation of nitric_oxide .
8660797	0	nitric_oxide	163,175	TNF-alpha	92,101	nitric oxide	TNF-alpha	MESH:D009569	21926(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY macrophages|nmod|production activation|nmod|macrophages lipid|dobj|activation associated|advcl|lipid END_ENTITY|acl|associated	Evidence for endogenous C1q modulates TNF-alpha_receptor synthesis and autocrine binding of TNF-alpha associated with lipid A activation of murine macrophages for nitric_oxide production .
9176264	0	nitric_oxide	87,99	TNF-alpha	61,70	nitric oxide	TNF-alpha	MESH:D009569	7124	Chemical	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|dysfunction dysfunction|acl|induced induced|nmod|END_ENTITY	Endothelial barrier dysfunction and p42 oxidation induced by TNF-alpha are mediated by nitric_oxide .
9249487	0	nitric_oxide	49,61	TNF-alpha	16,25	nitric oxide	TNF-alpha	MESH:D009569	24835(Tax:10116)	Chemical	Gene	Dissociation|nmod|START_ENTITY Dissociation|nmod|END_ENTITY	Dissociation of TNF-alpha from endotoxin-induced nitric_oxide and acute-phase_hypotension .
9367897	0	nitric_oxide	11,23	TNF-alpha	49,58	nitric oxide	TNF-alpha	MESH:D009569	21926(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY Control|nmod|production END_ENTITY|nsubj|Control	Control of nitric_oxide production by endogenous TNF-alpha in mouse retinal_pigmented_epithelial and Muller glial cells .
9541578	0	nitric_oxide	73,85	TNF-alpha	18,27	nitric oxide	TNF-alpha	MESH:D009569	21926(Tax:10090)	Chemical	Gene	production|nmod|START_ENTITY prerequisite|nmod|production prerequisite|nsubj|END_ENTITY	IFN-gamma-induced TNF-alpha is a prerequisite for in vitro production of nitric_oxide generated in murine peritoneal macrophages by IFN-gamma .
16081483	0	nitric_oxide	39,51	TRPV1	72,77	nitric oxide	TRPV1	MESH:D009569	83810(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	Anandamide elicits an acute release of nitric_oxide through endothelial TRPV1 receptor activation in the rat arterial mesenteric bed .
21712817	0	nitric_oxide	50,62	TRPV3	0,5	nitric oxide	TRPV3	MESH:D009569	162514	Chemical	Gene	synthesis|compound|START_ENTITY regulates|dobj|synthesis regulates|nsubj|END_ENTITY	TRPV3 regulates nitric_oxide synthase-independent nitric_oxide synthesis in the skin .
22004609	0	nitric_oxide	27,39	Thrombin	0,8	nitric oxide	Thrombin	MESH:D009569	29251(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Thrombin induces inducible nitric_oxide synthase expression via the MAPK , MSK1 , and NF-kB signaling pathways in alveolar macrophages .
7680540	0	nitric_oxide	31,43	Thrombin	0,8	nitric oxide	Thrombin	MESH:D009569	29251(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY induction|nmod|synthase inhibits|dobj|induction inhibits|nsubj|END_ENTITY	Thrombin inhibits induction of nitric_oxide synthase in vascular smooth muscle cells .
16150726	0	nitric_oxide	56,68	Thrombospondin-1	0,16	nitric oxide	Thrombospondin-1	MESH:D009569	21825(Tax:10090)	Chemical	Gene	inhibits|xcomp|START_ENTITY inhibits|nsubj|END_ENTITY	Thrombospondin-1 inhibits endothelial cell responses to nitric_oxide in a cGMP-dependent manner .
16489656	0	nitric_oxide	8,20	Toll-like_receptor_2	24,44	nitric oxide	Toll-like receptor 2	MESH:D009569	310553(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of nitric_oxide in Toll-like_receptor_2 and 4 mRNA expression in liver of acute_hemorrhagic_necrotizing_pancreatitis rats .
12794153	0	nitric_oxide	24,36	Toll-like_receptor_4	131,151	nitric oxide	Toll-like receptor 4	MESH:D009569	21898(Tax:10090)	Chemical	Gene	production|compound|START_ENTITY Induction|nmod|production involves|nsubj|Induction involves|xcomp|signaling signaling|nmod|complexes complexes|compound|END_ENTITY	Induction of macrophage nitric_oxide production by Gram-negative flagellin involves signaling via heteromeric Toll-like_receptor_5 / Toll-like_receptor_4 complexes .
12847273	0	nitric_oxide	105,117	Toll-like_receptor_4	47,67	nitric oxide	Toll-like receptor 4	MESH:D009569	21898(Tax:10090)	Chemical	Gene	activity|amod|START_ENTITY responses|nmod|activity suppresses|dobj|responses suppresses|nsubj|lipopolysaccharide lipopolysaccharide|acl|signaling signaling|nmod|END_ENTITY	Bacterial lipopolysaccharide signaling through Toll-like_receptor_4 suppresses asthma-like responses via nitric_oxide synthase 2 activity .
20388086	0	nitric_oxide	53,65	Toll-like_receptor_4	0,20	nitric oxide	Toll-like receptor 4	MESH:D009569	7099	Chemical	Gene	factor-alpha|compound|START_ENTITY release|nmod|factor-alpha mediates|dobj|release mediates|nsubj|END_ENTITY	Toll-like_receptor_4 mediates LPS-induced release of nitric_oxide and tumor necrosis factor-alpha by embryonal_cardiomyocytes : biological significance and clinical implications in human pathology .
21270629	0	nitric_oxide	96,108	Toll-like_receptor_4	0,20	nitric oxide	Toll-like receptor 4	MESH:D009569	21898(Tax:10090)	Chemical	Gene	mechanisms|amod|START_ENTITY ischemic_injury|nmod|mechanisms confers|nmod|ischemic_injury confers|nsubj|signaling signaling|compound|END_ENTITY	Toll-like_receptor_4 signaling confers cardiac protection against ischemic_injury via inducible nitric_oxide synthase - and soluble guanylate cyclase-dependent mechanisms .
24034933	0	nitric_oxide	126,138	Toll-like_receptor_4	13,33	nitric oxide	Toll-like receptor 4	MESH:D009569	7099	Chemical	Gene	dependent|amod|START_ENTITY way|amod|dependent replication|nmod|way inhibits|dobj|replication inhibits|nsubj|Induction Induction|nmod|END_ENTITY	Induction of Toll-like_receptor_4 signaling in avian macrophages inhibits infectious_laryngotracheitis_virus replication in a nitric_oxide dependent way .
24992835	0	nitric_oxide	15,27	Toll-like_receptor_4	47,67	nitric oxide	Toll-like receptor 4	MESH:D009569	21898(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Involvement of nitric_oxide with activation of Toll-like_receptor_4 signaling in mice with dextran sodium_sulfate-induced colitis .
7575617	0	nitric_oxide	91,103	Transforming_growth_factor-beta	0,31	nitric oxide	Transforming growth factor-beta	MESH:D009569	7040	Chemical	Gene	mRNA|amod|START_ENTITY expression|nmod|mRNA inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Transforming_growth_factor-beta inhibits the cytokine-mediated expression of the inducible nitric_oxide synthase mRNA in human retinal pigment epithelial cells .
19551451	0	nitric_oxide	75,87	Transforming_growth_factor-beta1	0,32	nitric oxide	Transforming growth factor-beta1	MESH:D009569	7040	Chemical	Gene	alter|dobj|START_ENTITY alter|nsubj|END_ENTITY	Transforming_growth_factor-beta1 -LRB- TGF-beta1 -RRB- and acetylcholine -LRB- ACh -RRB- alter nitric_oxide -LRB- NO -RRB- and interleukin-1beta -LRB- IL-1beta -RRB- secretion in human colon_adenocarcinoma cells .
16115393	0	nitric_oxide	55,67	Transforming_growth_factor_beta1	1,33	nitric oxide	Transforming growth factor beta1	MESH:D009569	59086(Tax:10116)	Chemical	Gene	synthase|compound|START_ENTITY correlates|dobj|synthase correlates|nsubj|END_ENTITY	-LSB- Transforming_growth_factor_beta1 correlates inducible nitric_oxide synthase in pulmonary arteries of rats with hypoxia-induced_pulmonary_hypertension -RSB- .
10098852	0	nitric_oxide	108,120	Tumor_necrosis_factor-alpha	0,27	nitric oxide	Tumor necrosis factor-alpha	MESH:D009569	24835(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY modulate|dobj|effect modulate|nsubj|differentially differentially|amod|END_ENTITY	Tumor_necrosis_factor-alpha and phorbol_12-myristate_13-acetate differentially modulate cytotoxic effect of nitric_oxide generated by serum deprivation in neuronal PC12 cells .
10554331	0	nitric_oxide	95,107	Tumor_necrosis_factor-alpha	0,27	nitric oxide	Tumor necrosis factor-alpha	MESH:D009569	21926(Tax:10090)	Chemical	Gene	prevented|nmod|START_ENTITY prevented|nsubjpass|apoptosis apoptosis|amod|END_ENTITY	Tumor_necrosis_factor-alpha plus actinomycin_D-induced apoptosis of L929 cells is prevented by nitric_oxide .
11905053	0	nitric_oxide	82,94	Tumor_necrosis_factor-alpha	1,28	nitric oxide	Tumor necrosis factor-alpha	MESH:D009569	7124	Chemical	Gene	-RSB-|amod|START_ENTITY expression|nmod|-RSB- modulate|nmod|expression modulate|nsubj|END_ENTITY	-LSB- Tumor_necrosis_factor-alpha and interferon-gamma modulate in vitro expression of nitric_oxide synthase in human nasal epithelial cells -RSB- .
11956484	0	nitric_oxide	76,88	Tumor_necrosis_factor-alpha	0,27	nitric oxide	Tumor necrosis factor-alpha	MESH:D009569	21926(Tax:10090)	Chemical	Gene	production|nmod|START_ENTITY mediate|dobj|production END_ENTITY|dep|mediate	Tumor_necrosis_factor-alpha and interleukin-1beta mediate the production of nitric_oxide involved in the pathogenesis of ifosfamide induced hemorrhagic_cystitis in mice .
16755653	0	nitric_oxide	57,69	Tumor_necrosis_factor-alpha	0,27	nitric oxide	Tumor necrosis factor-alpha	MESH:D009569	7124	Chemical	Gene	protects|nmod|START_ENTITY protects|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha protects synovial cells from nitric_oxide induced apoptosis through phosphoinositide 3-kinase Akt signal transduction .
16854437	0	nitric_oxide	118,130	Tumor_necrosis_factor-alpha	0,27	nitric oxide	Tumor necrosis factor-alpha	MESH:D009569	24835(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY increases|nmod|release increases|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha increases cerebral blood flow and ultrastructural capillary damage through the release of nitric_oxide in the rat brain .
18688046	0	nitric_oxide	54,66	Tumor_necrosis_factor-alpha	0,27	nitric oxide	Tumor necrosis factor-alpha	MESH:D009569	7124	Chemical	Gene	stability|amod|START_ENTITY endothelial|dobj|stability endothelial|nsubj|downregulates downregulates|amod|END_ENTITY	Tumor_necrosis_factor-alpha downregulates endothelial nitric_oxide synthase mRNA stability via translation elongation factor 1-alpha 1 .
7630111	0	nitric_oxide	63,75	Tumor_necrosis_factor-alpha	0,27	nitric oxide	Tumor necrosis factor-alpha	MESH:D009569	24835(Tax:10116)	Chemical	Gene	survival|compound|START_ENTITY modulation|nmod|survival modulation|amod|END_ENTITY	Tumor_necrosis_factor-alpha and interferon-gamma modulation of nitric_oxide and allograft survival .
7927208	0	nitric_oxide	46,58	Tumor_necrosis_factor-alpha	0,27	nitric oxide	Tumor necrosis factor-alpha	MESH:D009569	21926(Tax:10090)	Chemical	Gene	synthesis|compound|START_ENTITY regulates|nmod|synthesis regulates|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha regulates in vivo nitric_oxide synthesis and induces liver_injury during endotoxemia .
9834372	0	nitric_oxide	48,60	Tumor_necrosis_factor-alpha	0,27	nitric oxide	Tumor necrosis factor-alpha	MESH:D009569	24835(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha regulates inducible nitric_oxide synthase gene expression in the portal hypertensive gastric mucosa of the rat .
22566503	0	nitric_oxide	34,46	Tumor_necrosis_factor_a	0,23	nitric oxide	Tumor necrosis factor a	MESH:D009569	24835(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY decreases|dobj|expression decreases|nsubj|END_ENTITY	Tumor_necrosis_factor_a decreases nitric_oxide synthase type 3 expression primarily via Rho/Rho kinase in the thick ascending limb .
10755468	0	nitric_oxide	65,77	Tumor_necrosis_factor_alpha	0,27	nitric oxide	Tumor necrosis factor alpha	MESH:D009569	7124	Chemical	Gene	induced|nmod|START_ENTITY cytotoxicity|acl|induced enhances|dobj|cytotoxicity enhances|nsubj|END_ENTITY	Tumor_necrosis_factor_alpha enhances the cytotoxicity induced by nitric_oxide in cultured cerebral endothelial cells .
16399681	0	nitric_oxide	101,113	Tumor_necrosis_factor_alpha	0,27	nitric oxide	Tumor necrosis factor alpha	MESH:D009569	21926(Tax:10090)	Chemical	Gene	excitotoxicity|compound|START_ENTITY mediates|nmod|excitotoxicity mediates|nsubj|END_ENTITY	Tumor_necrosis_factor_alpha but not interleukin_1_beta mediates neuroprotection in response to acute nitric_oxide excitotoxicity .
7591147	0	nitric_oxide	99,111	Tumor_necrosis_factor_alpha	0,27	nitric oxide	Tumor necrosis factor alpha	MESH:D009569	21926(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY inducing|dobj|production mediates|advcl|inducing mediates|nsubj|END_ENTITY	Tumor_necrosis_factor_alpha mediates resistance to Trypanosoma_cruzi_infection in mice by inducing nitric_oxide production in infected gamma_interferon-activated macrophages .
7642312	0	nitric_oxide	95,107	Tumor_necrosis_factor_alpha	0,27	nitric oxide	Tumor necrosis factor alpha	MESH:D009569	21926(Tax:10090)	Chemical	Gene	induce|dobj|START_ENTITY acts|xcomp|induce acts|nsubj|END_ENTITY	Tumor_necrosis_factor_alpha acts as an autocrine second signal with gamma interferon to induce nitric_oxide in group B streptococcus-treated macrophages .
9405166	0	nitric_oxide	135,147	Tumor_necrosis_factor_alpha	0,27	nitric oxide	Tumor necrosis factor alpha	MESH:D009569	7124	Chemical	Gene	-|compound|START_ENTITY inducing|dobj|- cardiodepressant|advcl|inducing cardiodepressant|nsubj|END_ENTITY	Tumor_necrosis_factor_alpha -LRB- TNF_alpha -RRB- is cardiodepressant in pathophysiologically relevant concentrations without inducing inducible nitric_oxide - -LRB- NO -RRB- - synthase -LRB- iNOS -RRB- or triggering serious cytotoxicity .
9537427	0	nitric_oxide	38,50	Tumor_necrosis_factor_alpha	0,27	nitric oxide	Tumor necrosis factor alpha	MESH:D009569	24835(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Tumor_necrosis_factor_alpha regulates nitric_oxide synthase expression in portal hypertensive gastric_mucosa of rats .
21321094	0	nitric_oxide	31,43	Uncoupling_protein-2	0,20	nitric oxide	Uncoupling protein-2	MESH:D009569	7351	Chemical	Gene	START_ENTITY|nsubj|increases increases|amod|END_ENTITY	Uncoupling_protein-2 increases nitric_oxide production and TNFAIP3 pathway activation in pancreatic islets .
25015964	0	nitric_oxide	23,35	Urocortin_2	0,11	nitric oxide	Urocortin 2	MESH:D009569	103349224	Chemical	Gene	production|amod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Urocortin_2 stimulates nitric_oxide production in ventricular myocytes via Akt - and PKA-mediated phosphorylation of eNOS at serine 1177 .
10484382	0	nitric_oxide	18,30	VCAM-1	61,67	nitric oxide	VCAM-1	MESH:D009569	22329(Tax:10090)	Chemical	Gene	Role|nmod|START_ENTITY synthase|nsubj|Role synthase|nmod|regulation regulation|nmod|expression expression|compound|END_ENTITY	Role of inducible nitric_oxide synthase in the regulation of VCAM-1 expression in gut inflammation .
11961404	0	nitric_oxide	10,22	VCAM-1	32,38	nitric oxide	VCAM-1	MESH:D009569	7412	Chemical	Gene	inhibits|advmod|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Exogenous nitric_oxide inhibits VCAM-1 expression in human peritoneal mesothelial cells .
24046447	0	nitric_oxide	13,25	VE-cadherin	73,84	nitric oxide	VE-cadherin	MESH:D009569	12562(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|GTPases GTPases|compound|END_ENTITY	eNOS-derived nitric_oxide regulates endothelial barrier function through VE-cadherin and Rho GTPases .
10067972	0	nitric_oxide	9,21	VEGF	94,98	nitric oxide	VEGF	MESH:D009569	7422	Chemical	Gene	Role|nmod|START_ENTITY induced|nsubj|Role induced|nmod|END_ENTITY	Role for nitric_oxide in the hyperpermeability and hemodynamic changes induced by intravenous VEGF .
1566853	0	nitric_oxide	15,27	VIP	49,52	nitric oxide	VIP	MESH:D009569	7432	Chemical	Gene	START_ENTITY|nmod|cells cells|nmod|END_ENTITY	Stimulation of nitric_oxide from muscle cells by VIP : prejunctional enhancement of VIP release .
1566853	0	nitric_oxide	15,27	VIP	83,86	nitric oxide	VIP	MESH:D009569	7432	Chemical	Gene	Stimulation|nmod|START_ENTITY Stimulation|dep|enhancement enhancement|nmod|release release|compound|END_ENTITY	Stimulation of nitric_oxide from muscle cells by VIP : prejunctional enhancement of VIP release .
17673149	0	nitric_oxide	23,35	VIP	0,3	nitric oxide	VIP	MESH:D009569	22353(Tax:10090)	Chemical	Gene	production|compound|START_ENTITY limits|dobj|production limits|nsubj|END_ENTITY	VIP limits LPS-induced nitric_oxide production through IL-10 in NOD mice macrophages .
18972585	0	nitric_oxide	53,65	VIP	127,130	nitric oxide	VIP	MESH:D009569	117064(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Appetite suppressive effects of yeast hydrolysate on nitric_oxide synthase -LRB- NOS -RRB- expression and vasoactive intestinal peptide -LRB- VIP -RRB- immunoreactivity in hypothalamus .
7553768	0	nitric_oxide	44,56	VIP	116,119	nitric oxide	VIP	MESH:D009569	100735454	Chemical	Gene	START_ENTITY|ccomp|synapse synapse|advmod|exclusively exclusively|nmod|bodies bodies|compound|END_ENTITY	Do vasoactive intestinal peptide -LRB- VIP -RRB- - and nitric_oxide synthase-immunoreactive terminals synapse exclusively with VIP cell bodies in the submucous plexus of the guinea-pig ileum ?
7861544	0	nitric_oxide	77,89	VIP	49,52	nitric oxide	VIP	MESH:D009569	100352512(Tax:9986)	Chemical	Gene	relaxation|nmod|START_ENTITY Modulation|dep|relaxation Modulation|nmod|vasoactive_intestinal_polypeptide vasoactive_intestinal_polypeptide|appos|END_ENTITY	Modulation of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- - mediated relaxation by nitric_oxide and prostanoids in the rabbit corpus cavernosum .
7957315	0	nitric_oxide	91,103	VIP	45,48	nitric oxide	VIP	MESH:D009569	7432	Chemical	Gene	IGR39|nmod|START_ENTITY IGR39|nsubj|Inhibition Inhibition|nmod|peptide peptide|appos|END_ENTITY	Inhibition of vasoactive intestinal peptide -LRB- VIP -RRB- binding on human melanoma cells IGR39 by nitric_oxide : cGMP is not involved .
17161399	0	nitric_oxide	29,41	Vac14	11,16	nitric oxide	Vac14	MESH:D009569	55697	Chemical	Gene	synthase|compound|START_ENTITY END_ENTITY|nmod|synthase	Binding of Vac14 to neuronal nitric_oxide synthase : Characterisation of a new internal PDZ-recognition motif .
10336886	0	nitric_oxide	156,168	Vascular_endothelial_growth_factor	0,34	nitric oxide	Vascular endothelial growth factor	MESH:D009569	83785(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY attenuates|parataxis|role attenuates|nsubj|END_ENTITY	Vascular_endothelial_growth_factor attenuates leukocyte-endothelium interaction during acute endothelial_dysfunction : essential role of endothelium-derived nitric_oxide .
10435050	0	nitric_oxide	48,60	Vascular_endothelial_growth_factor	0,34	nitric oxide	Vascular endothelial growth factor	MESH:D009569	83785(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|up-regulates up-regulates|compound|END_ENTITY	Vascular_endothelial_growth_factor up-regulates nitric_oxide synthase expression in endothelial cells .
10455194	0	nitric_oxide	74,86	Vascular_endothelial_growth_factor	0,34	nitric oxide	Vascular endothelial growth factor	MESH:D009569	7422	Chemical	Gene	production|nmod|START_ENTITY signals|dobj|production signals|nsubj|END_ENTITY	Vascular_endothelial_growth_factor signals endothelial cell production of nitric_oxide and prostacyclin through flk-1 / KDR activation of c-Src .
10593375	0	nitric_oxide	36,48	Vascular_endothelial_growth_factor	0,34	nitric oxide	Vascular endothelial growth factor	MESH:D009569	7422	Chemical	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	Vascular_endothelial_growth_factor , nitric_oxide , and leptin follicular fluid levels correlate negatively with embryo quality in IVF patients .
11549592	0	nitric_oxide	117,129	Vascular_endothelial_growth_factor	0,34	nitric oxide	Vascular endothelial growth factor	MESH:D009569	7422	Chemical	Gene	angiogenesis|nmod|START_ENTITY modulates|dobj|angiogenesis modulates|nsubj|receptor-1 receptor-1|compound|END_ENTITY	Vascular_endothelial_growth_factor receptor-1 modulates vascular_endothelial_growth_factor-mediated angiogenesis via nitric_oxide .
11730812	0	nitric_oxide	171,183	Vascular_endothelial_growth_factor	0,34	nitric oxide	Vascular endothelial growth factor	MESH:D009569	83785(Tax:10116)	Chemical	Gene	generation|amod|START_ENTITY enhanced|nmod|generation enhanced|nsubjpass|synthesis synthesis|compound|END_ENTITY	Vascular_endothelial_growth_factor synthesis in vascular smooth muscle cells is enhanced by 7-ketocholesterol and lysophosphatidylcholine independently of their effect on nitric_oxide generation .
11877364	0	nitric_oxide	164,176	Vascular_endothelial_growth_factor	0,34	nitric oxide	Vascular endothelial growth factor	MESH:D009569	83785(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY inhibition|nmod|synthesis model|nmod|inhibition recruiting/activating|nmod|model necessary|advcl|recruiting/activating necessary|nsubj|END_ENTITY	Vascular_endothelial_growth_factor is necessary in the development of arteriosclerosis by recruiting/activating monocytes in a rat model of long-term inhibition of nitric_oxide synthesis .
12372425	0	nitric_oxide	103,115	Vascular_endothelial_growth_factor	0,34	nitric oxide	Vascular endothelial growth factor	MESH:D009569	22339(Tax:10090)	Chemical	Gene	mice|amod|START_ENTITY muscles|nmod|mice isolated|nmod|muscles cells|acl|isolated expressed|nmod|cells expressed|nsubjpass|END_ENTITY	Vascular_endothelial_growth_factor is expressed in endothelial cells isolated from skeletal muscles of nitric_oxide synthase knockout mice during prazosin-induced angiogenesis .
24168915	0	nitric_oxide	137,149	Vascular_endothelial_growth_factor	0,34	nitric oxide	Vascular endothelial growth factor	MESH:D009569	7422	Chemical	Gene	donors|compound|START_ENTITY pathophysiology|nmod|donors hypertension|dep|pathophysiology hypertension|amod|END_ENTITY	Vascular_endothelial_growth_factor inhibitor-induced hypertension : from pathophysiology to prevention and treatment based on long-acting nitric_oxide donors .
9443437	0	nitric_oxide	99,111	Vascular_endothelial_growth_factor	0,34	nitric oxide	Vascular endothelial growth factor	MESH:D009569	7422	Chemical	Gene	permeability|nmod|START_ENTITY enhances|dobj|permeability END_ENTITY|parataxis|enhances	Vascular_endothelial_growth_factor / vascular_permeability_factor enhances vascular permeability via nitric_oxide and prostacyclin .
23284999	0	nitric_oxide	17,29	Vaspin	0,6	nitric oxide	Vaspin	MESH:D009569	191570(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|increases increases|compound|END_ENTITY	Vaspin increases nitric_oxide bioavailability through the reduction of asymmetric dimethylarginine in vascular endothelial cells .
23121214	0	nitric_oxide	47,59	acetylcholinesterase	14,34	nitric oxide	acetylcholinesterase	MESH:D009569	83817(Tax:10116)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|activity activity|amod|END_ENTITY	Regulation of acetylcholinesterase activity by nitric_oxide in rat neuromuscular junction via N-methyl-D-aspartate receptor activation .
18586011	0	nitric_oxide	14,26	activator_protein-1	90,109	nitric oxide	activator protein-1	MESH:D009569	24516(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY Inhibition|nmod|production Inhibition|nmod|protein protein|amod|END_ENTITY	Inhibition of nitric_oxide production by the carbazole compound LCY-2-CHO via blockade of activator_protein-1 and CCAAT/enhancer-binding protein activation in microglia .
19174156	0	nitric_oxide	87,99	activator_protein-1	183,202	nitric oxide	activator protein-1	MESH:D009569	3727	Chemical	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	KB-34 , a newly synthesized chalcone derivative , inhibits lipopolysaccharide-stimulated nitric_oxide production in RAW 264.7 macrophages via heme_oxygenase-1 induction and blockade of activator_protein-1 .
14623767	0	nitric_oxide	68,80	adrenomedullin	38,52	nitric oxide	adrenomedullin	MESH:D009569	101103753	Chemical	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|action action|nmod|END_ENTITY	Direct coronary vasodilator action of adrenomedullin is mediated by nitric_oxide .
15093693	0	nitric_oxide	115,127	adrenomedullin	41,55	nitric oxide	adrenomedullin	MESH:D009569	25026(Tax:10116)	Chemical	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|Decrease Decrease|nmod|pressure pressure|acl|induced induced|nmod|END_ENTITY	Decrease in arterial pressure induced by adrenomedullin in the hypothalamic paraventricular nucleus is mediated by nitric_oxide and GABA .
16040721	0	nitric_oxide	125,137	adrenomedullin	16,30	nitric oxide	adrenomedullin	MESH:D009569	25026(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY inhibition|nmod|synthesis induced|nmod|inhibition induced|nsubj|Upregulation Upregulation|nmod|END_ENTITY	Upregulation of adrenomedullin and its receptor components during cardiomyocyte hypertrophy induced by chronic inhibition of nitric_oxide synthesis in rats .
16212982	0	nitric_oxide	24,36	adrenomedullin	134,148	nitric oxide	adrenomedullin	MESH:D009569	25026(Tax:10116)	Chemical	Gene	increases|amod|START_ENTITY induced|nmod|increases induced|advcl|END_ENTITY	Hypertension induced by nitric_oxide synthase inhibitor increases responsiveness of ventricular_myocardium and aorta of rat tissue to adrenomedullin stimulation in vitro .
20079376	0	nitric_oxide	12,24	adrenomedullin	65,79	nitric oxide	adrenomedullin	MESH:D009569	133	Chemical	Gene	channels|compound|START_ENTITY role|nmod|channels role|nmod|effect effect|nmod|END_ENTITY	The role of nitric_oxide and potassium channels in the effect of adrenomedullin in human internal thoracic arteries .
21595896	0	nitric_oxide	36,48	adrenomedullin	120,134	nitric oxide	adrenomedullin	MESH:D009569	25026(Tax:10116)	Chemical	Gene	activation|amod|START_ENTITY mediates|nsubj|activation mediates|nmod|END_ENTITY	Protein_kinase_A-dependent neuronal nitric_oxide synthase activation mediates the enhancement of baroreflex response by adrenomedullin in the nucleus tractus solitarii of rats .
8632695	0	nitric_oxide	78,90	adrenomedullin	21,35	nitric oxide	adrenomedullin	MESH:D009569	25026(Tax:10116)	Chemical	Gene	relation|acl|START_ENTITY Up-regulation|dep|relation Up-regulation|nmod|expression expression|compound|END_ENTITY	Up-regulation of rat adrenomedullin gene expression by endotoxin : relation to nitric_oxide synthesis .
10816692	0	nitric_oxide	46,58	alpha-MSH	0,9	nitric oxide	alpha-MSH	MESH:D009569	18976(Tax:10090)	Chemical	Gene	production|compound|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	alpha-MSH inhibits lipopolysaccharide induced nitric_oxide production in B16 mouse melanoma cells .
7882030	0	nitric_oxide	105,117	alpha-MSH	50,59	nitric oxide	alpha-MSH	MESH:D009569	24664(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY stimulates|nmod|release stimulates|dobj|release release|nmod|END_ENTITY	N-methyl-D-aspartate -LRB- NMDA -RRB- stimulates release of alpha-MSH from the rat hypothalamus through release of nitric_oxide .
10692112	0	nitric_oxide	47,59	alpha-melanocyte-stimulating_hormone	0,36	nitric oxide	alpha-melanocyte-stimulating hormone	MESH:D009569	5443	Chemical	Gene	START_ENTITY|nsubj|modulates modulates|amod|END_ENTITY	alpha-melanocyte-stimulating_hormone modulates nitric_oxide production in melanocytes .
17196933	0	nitric_oxide	21,33	androgen_receptor	133,150	nitric oxide	androgen receptor	MESH:D009569	367	Chemical	Gene	production|amod|START_ENTITY pathway|nmod|production pathway|dep|involvement involvement|nmod|END_ENTITY	Signaling pathway of nitric_oxide production induced by ginsenoside_Rb1 in human aortic endothelial cells : a possible involvement of androgen_receptor .
20416296	0	nitric_oxide	36,48	androgen_receptor	15,32	nitric oxide	androgen receptor	MESH:D009569	367	Chemical	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	Involvement of androgen_receptor in nitric_oxide production induced by icariin in human umbilical vein endothelial cells .
9041368	0	nitric_oxide	37,49	androgen_receptor	16,33	nitric oxide	androgen receptor	MESH:D009569	24208(Tax:10116)	Chemical	Gene	neurons|amod|START_ENTITY END_ENTITY|nmod|neurons	Localization of androgen_receptor in nitric_oxide synthase - and vasoactive intestinal peptide-containing neurons of the major pelvic ganglion innervating the rat penis .
20348277	0	nitric_oxide	72,84	angiopoietin-2	134,148	nitric oxide	angiopoietin-2	MESH:D009569	285	Chemical	Gene	deficiency|amod|START_ENTITY deficiency|acl:relcl|occurs occurs|nmod|END_ENTITY	Defective_angiogenesis in hypoplastic human fetal lungs correlates with nitric_oxide synthase deficiency that occurs despite enhanced angiopoietin-2 and VEGF .
10523324	0	nitric_oxide	114,126	angiotensin-converting_enzyme	48,77	nitric oxide	angiotensin-converting enzyme	MESH:D009569	24310(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY blockade|nmod|synthesis activation|nmod|blockade activation|amod|END_ENTITY	Pathogenic role of oxidative stress in vascular angiotensin-converting_enzyme activation in long-term blockade of nitric_oxide synthesis in rats .
10535387	0	nitric_oxide	17,29	angiotensin-converting_enzyme	96,125	nitric oxide	angiotensin-converting enzyme	MESH:D009569	1636	Chemical	Gene	factors|amod|START_ENTITY levels|nmod|factors levels|nmod|treatment treatment|nmod|inhibitor inhibitor|amod|END_ENTITY	Plasma levels of nitric_oxide and related vasoactive factors following long-term treatment with angiotensin-converting_enzyme inhibitor in patients with essential hypertension .
10805420	0	nitric_oxide	98,110	angiotensin-converting_enzyme	18,47	nitric oxide	angiotensin-converting enzyme	MESH:D009569	419953(Tax:9031)	Chemical	Gene	inhibition|compound|START_ENTITY activity|nmod|inhibition activity|amod|END_ENTITY	Changes in plasma angiotensin-converting_enzyme activity and noradrenaline responses to long-term nitric_oxide inhibition vary depending on their basal values in chickens .
10899101	0	nitric_oxide	115,127	angiotensin-converting_enzyme	47,76	nitric oxide	angiotensin-converting enzyme	MESH:D009569	24310(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY Improvement|dep|role Improvement|nmod|function function|nmod|inhibition inhibition|amod|END_ENTITY	Improvement of endothelial function by chronic angiotensin-converting_enzyme inhibition in heart_failure : role of nitric_oxide , prostanoids , oxidant stress , and bradykinin .
11499734	0	nitric_oxide	8,20	angiotensin-converting_enzyme	39,68	nitric oxide	angiotensin-converting enzyme	MESH:D009569	1636	Chemical	Gene	production|compound|START_ENTITY production|amod|due due|nmod|inhibition inhibition|amod|END_ENTITY	Cardiac nitric_oxide production due to angiotensin-converting_enzyme inhibition decreases beta-adrenergic myocardial contractility in patients with dilated_cardiomyopathy .
12963679	0	nitric_oxide	18,30	angiotensin-converting_enzyme	48,77	nitric oxide	angiotensin-converting enzyme	MESH:D009569	11421(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|effect effect|nmod|inhibitor inhibitor|amod|END_ENTITY	Important role of nitric_oxide in the effect of angiotensin-converting_enzyme inhibitor imidapril on vascular_injury .
16968466	0	nitric_oxide	30,42	angiotensin-converting_enzyme	82,111	nitric oxide	angiotensin-converting enzyme	MESH:D009569	1636	Chemical	Gene	START_ENTITY|nmod|patients patients|acl|taking taking|dobj|therapy therapy|amod|END_ENTITY	Increased cardiac endothelial nitric_oxide synthase expression in patients taking angiotensin-converting_enzyme inhibitor therapy .
23271616	0	nitric_oxide	164,176	angiotensin-converting_enzyme	40,69	nitric oxide	angiotensin-converting enzyme	MESH:D009569	24310(Tax:10116)	Chemical	Gene	inhibitor|amod|START_ENTITY treated|nmod|inhibitor rats|dep|treated Effects|nmod|rats Effects|nmod|oxygen oxygen|amod|END_ENTITY	Effects of taxifolin on the activity of angiotensin-converting_enzyme and reactive oxygen and nitrogen species in the aorta of aging rats and rats treated with the nitric_oxide synthase inhibitor and dexamethasone .
9403592	0	nitric_oxide	176,188	angiotensin-converting_enzyme	8,37	nitric oxide	angiotensin-converting enzyme	MESH:D009569	24310(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY blockade|nmod|synthesis induced|nmod|blockade rats|acl|induced remodeling|nmod|rats effects|nmod|remodeling inhibition|dep|effects inhibition|amod|END_ENTITY	Chronic angiotensin-converting_enzyme inhibition and angiotensin_II_type_1_receptor blockade : effects on cardiovascular remodeling in rats induced by the long-term blockade of nitric_oxide synthesis .
9641545	0	nitric_oxide	47,59	angiotensin-converting_enzyme	14,43	nitric oxide	angiotensin-converting enzyme	MESH:D009569	24310(Tax:10116)	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|END_ENTITY	Modulation of angiotensin-converting_enzyme by nitric_oxide .
9918584	0	nitric_oxide	24,36	angiotensin-converting_enzyme	89,118	nitric oxide	angiotensin-converting enzyme	MESH:D009569	610668(Tax:9615)	Chemical	Gene	production|amod|START_ENTITY contributes|nsubj|production contributes|nmod|action action|nmod|inhibitors inhibitors|amod|END_ENTITY	Kinin-mediated coronary nitric_oxide production contributes to the therapeutic action of angiotensin-converting_enzyme and neutral endopeptidase inhibitors and amlodipine in the treatment in heart_failure .
9925380	0	nitric_oxide	58,70	angiotensin-converting_enzyme	14,43	nitric oxide	angiotensin-converting enzyme	MESH:D009569	610668(Tax:9615)	Chemical	Gene	levels|amod|START_ENTITY increases|dobj|levels increases|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of angiotensin-converting_enzyme increases the nitric_oxide levels in canine ischemic myocardium .
10069678	0	nitric_oxide	34,46	angiotensin_II	70,84	nitric oxide	angiotensin II	MESH:D009569	183	Chemical	Gene	radicals|compound|START_ENTITY stimulation|nmod|radicals Acute|dobj|stimulation Acute|nmod|END_ENTITY	Acute simultaneous stimulation of nitric_oxide and oxygen radicals by angiotensin_II in humans in vivo .
10398211	0	nitric_oxide	86,98	angiotensin_II	26,40	nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY vasoreactivity|dep|role vasoreactivity|nmod|END_ENTITY	Altered vasoreactivity to angiotensin_II in experimental diabetic_neuropathy : role of nitric_oxide .
10409263	0	nitric_oxide	64,76	angiotensin_II	8,22	nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	inhibition|amod|START_ENTITY effects|nmod|inhibition modulating|dobj|effects END_ENTITY|acl|modulating	Role of angiotensin_II in modulating the hemodynamic effects of nitric_oxide synthesis inhibition .
10556500	0	nitric_oxide	27,39	angiotensin_II	102,116	nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY modulation|nmod|release stimulated|nsubj|modulation stimulated|nmod|END_ENTITY	Differential modulation of nitric_oxide and prostacyclin release in senescent rat heart stimulated by angiotensin_II .
10645927	0	nitric_oxide	167,179	angiotensin_II	24,38	nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY blockade|nmod|synthesis induced|nmod|blockade changes|acl|induced pathogenesis|nmod|changes receptor|nmod|pathogenesis mediated|dobj|receptor mediated|nsubj|role role|nmod|activity activity|compound|END_ENTITY	Important role of local angiotensin_II activity mediated via type 1 receptor in the pathogenesis of cardiovascular inflammatory changes induced by chronic blockade of nitric_oxide synthesis in rats .
10846613	0	nitric_oxide	13,25	angiotensin_II	68,82	nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY Effects|nmod|synthase inhibitor|nsubj|Effects inhibitor|nmod|END_ENTITY	Effects of a nitric_oxide synthase inhibitor on pressor response to angiotensin_II in conscious rats .
10862636	0	nitric_oxide	38,50	angiotensin_II	11,25	nitric oxide	angiotensin II	MESH:D009569	183	Chemical	Gene	levels|amod|START_ENTITY Effects|nmod|levels Effects|nmod|blockade blockade|amod|END_ENTITY	Effects of angiotensin_II blockade on nitric_oxide blood levels in IgA_nephropathy .
10988340	0	nitric_oxide	91,103	angiotensin_II	18,32	nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	due|xcomp|START_ENTITY accompany|xcomp|due accompany|nsubj|levels levels|compound|END_ENTITY	Unchanged cardiac angiotensin_II levels accompany losartan-sensitive cardiac_injury due to nitric_oxide synthase inhibition .
11025760	0	nitric_oxide	15,27	angiotensin_II	76,90	nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	factor-beta1|amod|START_ENTITY Interaction|nmod|factor-beta1 induced|nsubj|Interaction induced|nmod|END_ENTITY	Interaction of nitric_oxide and transforming growth factor-beta1 induced by angiotensin_II and mechanical stretch in rat renal tubular epithelial cells .
11103753	0	nitric_oxide	94,106	angiotensin_II	10,24	nitric oxide	angiotensin II	MESH:D009569	183	Chemical	Gene	metabolism|amod|START_ENTITY blockade|nmod|metabolism infusion|nmod|blockade infusion|amod|END_ENTITY	Effect of angiotensin_II infusion with and without angiotensin_II_type_1_receptor blockade on nitric_oxide metabolism and endothelin in human beings : a placebo-controlled study in healthy volunteers .
11132603	0	nitric_oxide	22,34	angiotensin_II	116,130	nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY inhibition|nmod|synthesis increases|nsubj|inhibition increases|dobj|production production|nmod|action action|nmod|END_ENTITY	Chronic inhibition of nitric_oxide synthesis in rats increases aortic superoxide anion production via the action of angiotensin_II .
11231039	0	nitric_oxide	8,20	angiotensin_II	70,84	nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY induced|nsubj|Role induced|nmod|END_ENTITY	Role of nitric_oxide on atrial_natriuretic_peptide release induced by angiotensin_II in superfused rat atrial tissue .
11518848	0	nitric_oxide	51,63	angiotensin_II	18,32	nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY inhibition|nmod|synthase inhibition|nsubj|Effect Effect|nmod|END_ENTITY	Effect of chronic angiotensin_II inhibition on the nitric_oxide synthase in the normal rat during aging .
11805851	0	nitric_oxide	43,55	angiotensin_II	117,131	nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	inhibition|amod|START_ENTITY resulting|nmod|inhibition hypertension|acl|resulting associated|nsubjpass|hypertension associated|nmod|loss loss|nmod|regulation regulation|nmod|END_ENTITY	Salt-sensitive hypertension resulting from nitric_oxide synthase inhibition is associated with loss of regulation of angiotensin_II in the rat .
11851644	0	nitric_oxide	6,18	angiotensin_II	60,74	nitric oxide	angiotensin II	MESH:D009569	183	Chemical	Gene	release|compound|START_ENTITY affect|nsubj|release affect|nmod|END_ENTITY	Local nitric_oxide release does not affect tachyphylaxis to angiotensin_II in dorsal hand veins in man in the presence of prostaglandin synthesis inhibition .
11882637	0	nitric_oxide	44,56	angiotensin_II	63,77	nitric oxide	angiotensin II	MESH:D009569	183	Chemical	Gene	START_ENTITY|nmod|blockade blockade|amod|END_ENTITY	Renal hemodynamic control by endothelin and nitric_oxide under angiotensin_II blockade in man .
11951115	0	nitric_oxide	45,57	angiotensin_II	111,125	nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY inhibition|nmod|synthesis protein_kinase_C|nmod|inhibition Effect|nmod|protein_kinase_C cardiomyocytes|nsubj|Effect cardiomyocytes|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Effect of protein_kinase_C on inhibition of nitric_oxide synthesis in cultured neonatal rat cardiomyocytes by angiotensin_II -RSB- .
12069953	0	nitric_oxide	16,28	angiotensin_II	85,99	nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	deficit|compound|START_ENTITY enhances|nsubj|deficit enhances|dobj|actions actions|nmod|END_ENTITY	Renal medullary nitric_oxide deficit of Dahl S rats enhances hypertensive actions of angiotensin_II .
12075467	0	nitric_oxide	24,36	angiotensin_II	104,118	nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	mechanism|nmod|START_ENTITY induced|nsubj|mechanism induced|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Molecular mechanism of nitric_oxide in preventing cardiomyocytes from hypertrophic response induced by angiotensin_II -RSB- .
12473874	0	nitric_oxide	60,72	angiotensin_II	10,24	nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY activities|amod|synthase increases|dobj|activities increases|nsubj|inhibition inhibition|compound|END_ENTITY	Long-term angiotensin_II inhibition increases mitochondrial nitric_oxide synthase and not antioxidant enzyme activities in rat heart .
14510783	0	nitric_oxide	89,101	angiotensin_II	40,54	nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	modulation|nmod|START_ENTITY mediated|nmod|modulation mediated|nsubjpass|Facilitation Facilitation|nmod|autoregulation autoregulation|nmod|END_ENTITY	Facilitation of renal autoregulation by angiotensin_II is mediated through modulation of nitric_oxide .
14597853	0	nitric_oxide	29,41	angiotensin_II	11,25	nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	generation|amod|START_ENTITY END_ENTITY|nmod|generation	Effects of angiotensin_II on nitric_oxide generation in growing and resting rat aortic endothelial cells .
14620932	0	nitric_oxide	29,41	angiotensin_II	11,25	nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	generation|amod|START_ENTITY END_ENTITY|nmod|generation	Effects of angiotensin_II on nitric_oxide generation in proliferating and quiescent rat coronary microvascular endothelial cells .
15198935	0	nitric_oxide	26,38	angiotensin_II	47,61	nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	administration|nmod|START_ENTITY reduces|nsubj|administration reduces|iobj|type type|amod|END_ENTITY	Chronic administration of nitric_oxide reduces angiotensin_II receptor type 1 expression and aldosterone synthesis in zona glomerulosa cells .
15295720	0	nitric_oxide	63,75	angiotensin_II	16,30	nitric oxide	angiotensin II	MESH:D009569	183	Chemical	Gene	reduce|ccomp|START_ENTITY reduce|nsubj|levels levels|nmod|END_ENTITY	Tonic levels of angiotensin_II reduce tonic levels of vascular nitric_oxide even in salt-replete man .
15491410	0	nitric_oxide	51,63	angiotensin_II	20,34	nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of exogenous angiotensin_II on renal tissue nitric_oxide and intrarenal circulation in anaesthetized rats .
15941833	0	nitric_oxide	50,62	angiotensin_II	91,105	nitric oxide	angiotensin II	MESH:D009569	183	Chemical	Gene	bioavailability|amod|START_ENTITY bioavailability|nmod|END_ENTITY	Endothelial dihydrofolate_reductase : critical for nitric_oxide bioavailability and role in angiotensin_II uncoupling of endothelial_nitric_oxide_synthase .
16580888	0	nitric_oxide	37,49	angiotensin_II	13,27	nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY mediated|dobj|release mediated|nsubj|Detection Detection|nmod|END_ENTITY	Detection of angiotensin_II mediated nitric_oxide release within the nucleus of the solitary tract using electron-paramagnetic resonance -LRB- EPR -RRB- spectroscopy .
16857953	0	nitric_oxide	55,67	angiotensin_II	80,94	nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	activation|nmod|START_ENTITY synthase|nsubj|activation synthase|nmod|END_ENTITY	Sphingosine kinase-dependent activation of endothelial nitric_oxide synthase by angiotensin_II .
16951043	0	nitric_oxide	125,137	angiotensin_II	61,75	nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	independent|nmod|START_ENTITY produced|nmod|independent produced|nmod|END_ENTITY	Superoxide mediates acute renal vasoconstriction produced by angiotensin_II and catecholamines by a mechanism independent of nitric_oxide .
17143071	8	nitric_oxide	1344,1356	angiotensin_II	1314,1328	nitric oxide	angiotensin II	MESH:D009569	183	Chemical	Gene	system|amod|START_ENTITY stimulates|dobj|system stimulates|nsubj|END_ENTITY	SUMMARY : Recent studies show that angiotensin_II stimulates the nitric_oxide system via angiotensin_II type 1 and angiotensin_II type 2 receptors , whereas receptors exert different effects on renal and medullary flow .
17717927	0	nitric_oxide	53,65	angiotensin_II	30,44	nitric oxide	angiotensin II	MESH:D009569	183	Chemical	Gene	production|amod|START_ENTITY induced|dobj|production END_ENTITY|acl|induced	-LSB- Effect of tanshinone_II_A on angiotensin_II induced nitric_oxide production and endothelial nitric_oxide synthase gene expression in cultured porcine aortic endothelial cells -RSB- .
17717927	0	nitric_oxide	93,105	angiotensin_II	30,44	nitric oxide	angiotensin II	MESH:D009569	183	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|tanshinone_II_A tanshinone_II_A|nmod|END_ENTITY	-LSB- Effect of tanshinone_II_A on angiotensin_II induced nitric_oxide production and endothelial nitric_oxide synthase gene expression in cultured porcine aortic endothelial cells -RSB- .
19959193	0	nitric_oxide	25,37	angiotensin_II	109,123	nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	Expressions|nmod|START_ENTITY Expressions|dep|role role|nmod|END_ENTITY	Expressions of inducible nitric_oxide synthase and cyclooxygenase-2 in gastric_ischemia-reperfusion : role of angiotensin_II .
21511303	0	nitric_oxide	130,142	angiotensin_II	10,24	nitric oxide	angiotensin II	MESH:D009569	183	Chemical	Gene	relaxation|amod|START_ENTITY modulation|nmod|relaxation Effect|dep|modulation Effect|nmod|END_ENTITY	Effect of angiotensin_II and its receptor antagonists on human corpus cavernous contractility and oxidative stress : modulation of nitric_oxide mediated relaxation .
21670419	0	nitric_oxide	47,59	angiotensin_II	84,98	nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	excretion|amod|START_ENTITY excretion|nmod|END_ENTITY	Relaxin ameliorates hypertension and increases nitric_oxide metabolite excretion in angiotensin_II but not N -LRB- __ -RRB- - nitro-L-arginine_methyl_ester hypertensive rats .
22484619	0	nitric_oxide	9,21	angiotensin_II	50,64	nitric oxide	angiotensin II	MESH:D009569	11606(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY up-regulated|nsubj|synthase up-regulated|nmod|END_ENTITY	Neuronal nitric_oxide synthase is up-regulated by angiotensin_II and attenuates NADPH oxidase activity and facilitates relaxation in murine left ventricular myocytes .
22835814	0	nitric_oxide	118,130	angiotensin_II	100,114	nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	connection|amod|START_ENTITY END_ENTITY|dep|connection	Apocynum venetum leaf extract , an antihypertensive herb , inhibits rat aortic contraction induced by angiotensin_II : a nitric_oxide and superoxide connection .
23207895	0	nitric_oxide	111,123	angiotensin_II	74,88	nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY reactivity|appos|receptor reactivity|nmod|END_ENTITY	Mesangial cells cultured from pregnant rats display reduced reactivity to angiotensin_II : the role of relaxin , nitric_oxide and AT2 receptor .
23407814	0	nitric_oxide	8,20	angiotensin_II	83,97	nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY induced|nsubj|Role induced|nmod|END_ENTITY	Role of nitric_oxide and cGMP in the modulation of vascular contraction induced by angiotensin_II and Bay_K8644 during ischemia/reperfusion .
7538750	0	nitric_oxide	21,33	angiotensin_II	75,89	nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY synthases|nsubj|Role synthases|nmod|END_ENTITY	-LSB- Role of endothelial nitric_oxide synthases in the contractile response to angiotensin_II of the aorta in rats .
7591014	0	nitric_oxide	36,48	angiotensin_II	59,73	nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY decreases|nsubj|release decreases|dobj|contractions contractions|amod|END_ENTITY	Endothelial AT1-mediated release of nitric_oxide decreases angiotensin_II contractions in rat carotid artery .
7644529	0	nitric_oxide	46,58	angiotensin_II	103,117	nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY stimulation|nmod|expression counteracted|nsubjpass|stimulation counteracted|nmod|END_ENTITY	Tonic stimulation of renin gene expression by nitric_oxide is counteracted by tonic inhibition through angiotensin_II .
7682650	0	nitric_oxide	118,130	angiotensin_II	27,41	nitric oxide	angiotensin II	MESH:D009569	11606(Tax:10090)	Chemical	Gene	synthesis|amod|START_ENTITY cyclase|nmod|synthesis activation|nmod|cyclase New|dep|activation New|acl|signaling signaling|dobj|mechanism mechanism|nmod|END_ENTITY	New signaling mechanism of angiotensin_II in neuroblastoma neuro-2A cells : activation of soluble guanylyl cyclase via nitric_oxide synthesis .
8286713	0	nitric_oxide	79,91	angiotensin_II	16,30	nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	Contribution|acl|START_ENTITY Contribution|nmod|END_ENTITY	Contribution of angiotensin_II to renal hemodynamic and excretory responses to nitric_oxide synthesis inhibition in the rat .
8340065	0	nitric_oxide	77,89	angiotensin_II	27,41	nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY responsiveness|dep|role responsiveness|nmod|END_ENTITY	Impaired responsiveness to angiotensin_II in experimental cirrhosis : role of nitric_oxide .
8621213	0	nitric_oxide	8,20	angiotensin_II	60,74	nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of nitric_oxide in short-term and prolonged effects of angiotensin_II on renal hemodynamics .
8707375	0	nitric_oxide	53,65	angiotensin_II	11,25	nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	infusion|nmod|START_ENTITY infusion|compound|END_ENTITY	Effects of angiotensin_II infusion and inhibition of nitric_oxide synthase on the rat aorta .
8713687	0	nitric_oxide	64,76	angiotensin_II	11,25	nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY receptors|nmod|inhibition receptors|amod|END_ENTITY	A study of angiotensin_II receptors after chronic inhibition of nitric_oxide synthase in the spontaneously hypertensive rat .
8851506	0	nitric_oxide	14,26	angiotensin_II	79,93	nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|END_ENTITY	Modulation by nitric_oxide and prostaglandin of the renal vascular response to angiotensin_II -LRB- 3-8 -RRB- .
8984951	0	nitric_oxide	9,21	angiotensin_II	68,82	nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|modulation modulation|nmod|response response|nmod|END_ENTITY	-LSB- Role of nitric_oxide in the modulation of the vascular response to angiotensin_II in hypertensive rats -RSB- .
9048738	0	nitric_oxide	32,44	angiotensin_II	109,123	nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY synthase|dep|modulation modulation|nmod|END_ENTITY	Cytokine - and endotoxin-induced nitric_oxide synthase in rat astroglial cultures : differential modulation by angiotensin_II .
9059851	0	nitric_oxide	49,61	angiotensin_II	81,95	nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	differences|nmod|START_ENTITY differences|nmod|responses responses|amod|END_ENTITY	Age-related differences and roles of endothelial nitric_oxide and prostanoids in angiotensin_II responses of isolated , perfused mesenteric arteries and veins of rats .
9266887	0	nitric_oxide	8,20	angiotensin_II	52,66	nitric oxide	angiotensin II	MESH:D009569	183	Chemical	Gene	change|nsubj|START_ENTITY change|dobj|formation formation|compound|END_ENTITY	Inhaled nitric_oxide does not change transpulmonary angiotensin_II formation in patients with acute respiratory_distress_syndrome .
9315490	0	nitric_oxide	75,87	angiotensin_II	10,24	nitric oxide	angiotensin II	MESH:D009569	183	Chemical	Gene	environment|amod|START_ENTITY cavernosum|nmod|environment cavernosum|nsubj|Effect Effect|nmod|END_ENTITY	Effect of angiotensin_II on corpus cavernosum smooth muscle in relation to nitric_oxide environment : in vitro studies in canines .
9369252	0	nitric_oxide	10,22	angiotensin_II	53,67	nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY induced|nsubj|Effect induced|nmod|END_ENTITY	Effect of nitric_oxide on DNA replication induced by angiotensin_II in rat cardiac fibroblasts .
9369275	0	nitric_oxide	89,101	angiotensin_II	11,25	nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	generation|compound|START_ENTITY regulates|dobj|generation regulates|nsubj|END_ENTITY	Endogenous angiotensin_II produced by endothelium regulates interleukin-1beta-stimulated nitric_oxide generation in rat isolated vessels .
9401758	0	nitric_oxide	106,118	angiotensin_II	14,28	nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY vivo|nmod|release femoral|nmod|vivo femoral|nsubj|Dilatation Dilatation|nmod|END_ENTITY	Dilatation by angiotensin_II of the rat femoral arterial bed in vivo via pressure/flow-induced release of nitric_oxide and prostaglandins .
9736302	0	nitric_oxide	68,80	angiotensin_II	29,43	nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	blockade|amod|START_ENTITY vasoconstriction|nmod|blockade vasoconstriction|nsubj|Role Role|nmod|eicosanoids eicosanoids|nmod|END_ENTITY	Role of eicosanoids in renal angiotensin_II vasoconstriction during nitric_oxide blockade .
9758645	0	nitric_oxide	76,88	angiotensin_II	8,22	nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY inhibition|nmod|synthesis upregulated|nmod|inhibition upregulated|nsubjpass|receptors receptors|compound|END_ENTITY	Cardiac angiotensin_II receptors are upregulated by long-term inhibition of nitric_oxide synthesis in rats .
9851944	0	nitric_oxide	9,21	angiotensin_II	95,109	nitric oxide	angiotensin II	MESH:D009569	24179(Tax:10116)	Chemical	Gene	synthase|compound|START_ENTITY synthase|dep|activation activation|nmod|END_ENTITY	Neuronal nitric_oxide synthase is expressed in rat vascular smooth muscle cells : activation by angiotensin_II in hypertension .
10774787	0	nitric_oxide	56,68	angiotensin_II_type_1_receptor	11,41	nitric oxide	angiotensin II type 1 receptor	MESH:D009569	81638(Tax:10116)	Chemical	Gene	antagonist|nmod|START_ENTITY antagonist|amod|END_ENTITY	Effects of angiotensin_II_type_1_receptor antagonist on nitric_oxide synthase expression and myocardial_remodeling in Goldblatt hypertensive rats .
11103753	0	nitric_oxide	94,106	angiotensin_II_type_1_receptor	51,81	nitric oxide	angiotensin II type 1 receptor	MESH:D009569	185	Chemical	Gene	metabolism|amod|START_ENTITY blockade|nmod|metabolism blockade|amod|END_ENTITY	Effect of angiotensin_II infusion with and without angiotensin_II_type_1_receptor blockade on nitric_oxide metabolism and endothelin in human beings : a placebo-controlled study in healthy volunteers .
11171786	0	nitric_oxide	105,117	angiotensin_II_type_1_receptor	41,71	nitric oxide	angiotensin II type 1 receptor	MESH:D009569	185	Chemical	Gene	bioavailability|nmod|START_ENTITY antagonism|nmod|bioavailability antagonism|amod|END_ENTITY	Comparative effect of ace inhibition and angiotensin_II_type_1_receptor antagonism on bioavailability of nitric_oxide in patients with coronary_artery_disease : role of superoxide dismutase .
16832158	0	nitric_oxide	73,85	angiotensin_II_type_1_receptor	11,41	nitric oxide	angiotensin II type 1 receptor	MESH:D009569	81638(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|blockade blockade|amod|END_ENTITY	Effects of angiotensin_II_type_1_receptor blockade on the systemic blood nitric_oxide dynamics in Nomega-nitro-L-arginine_methyl_ester-treated rats .
16980435	0	nitric_oxide	26,38	angiotensin_II_type_1_receptor	55,85	nitric oxide	angiotensin II type 1 receptor	MESH:D009569	81638(Tax:10116)	Chemical	Gene	Activation|nmod|START_ENTITY synthase|nsubj|Activation synthase|nmod|END_ENTITY	Activation of endothelial nitric_oxide synthase by the angiotensin_II_type_1_receptor .
19307231	0	nitric_oxide	86,98	angiotensin_II_type_1_receptor	39,69	nitric oxide	angiotensin II type 1 receptor	MESH:D009569	185	Chemical	Gene	synthase|amod|START_ENTITY synthase|amod|END_ENTITY	Valsartan regulates the interaction of angiotensin_II_type_1_receptor and endothelial nitric_oxide synthase via Src/PI3K/Akt signalling .
19462315	0	nitric_oxide	69,81	angiotensin_II_type_1_receptor	26,56	nitric oxide	angiotensin II type 1 receptor	MESH:D009569	185	Chemical	Gene	blockade|nmod|START_ENTITY blockade|amod|END_ENTITY	Effects of cardiovascular angiotensin_II_type_1_receptor blockade on nitric_oxide synthase inhibition in patients with insulin_resistance_syndrome .
22292721	0	nitric_oxide	143,155	angiotensin_II_type_1_receptor	23,53	nitric oxide	angiotensin II type 1 receptor	MESH:D009569	81638(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY Effect|nmod|synthesis Effect|nmod|losartan losartan|appos|antagonist antagonist|amod|END_ENTITY	Effect of losartan , an angiotensin_II_type_1_receptor antagonist on cardiac autonomic functions of rats during acute and chronic inhibition of nitric_oxide synthesis .
9453326	0	nitric_oxide	71,83	angiotensin_II_type_1_receptor	18,48	nitric oxide	angiotensin II type 1 receptor	MESH:D009569	81638(Tax:10116)	Chemical	Gene	transcription|nmod|START_ENTITY transcription|nsubj|Downregulation Downregulation|nmod|gene gene|amod|END_ENTITY	Downregulation of angiotensin_II_type_1_receptor gene transcription by nitric_oxide .
12361694	0	nitric_oxide	45,57	antithrombin-III	15,31	nitric oxide	antithrombin-III	MESH:D009569	304917(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|END_ENTITY	The effects of antithrombin-III on inducible nitric_oxide synthesis in experimental obstructive_jaundice .
10827377	0	nitric_oxide	170,182	apolipoprotein_E	127,143	nitric oxide	apolipoprotein E	MESH:D009569	348	Chemical	Gene	synthase|compound|START_ENTITY synthase|dep|END_ENTITY	Acute myocardial_infarction in young adults : prognostic role of angiotensin-converting_enzyme , _ angiotensin_II_type_I_receptor , apolipoprotein_E , endothelial constitutive nitric_oxide synthase , and glycoprotein IIIa genetic polymorphisms at medium-term follow-up .
21106532	0	nitric_oxide	53,65	argininosuccinate_synthetase_1	12,42	nitric oxide	argininosuccinate synthetase 1	MESH:D009569	445	Chemical	Gene	production|amod|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	Endothelial argininosuccinate_synthetase_1 regulates nitric_oxide production and monocyte adhesion under static and laminar shear stress conditions .
12776351	0	nitric_oxide	51,63	artemin	22,29	nitric oxide	artemin	MESH:D009569	11876(Tax:10090)	Chemical	Gene	synthesis|compound|START_ENTITY END_ENTITY|nmod|synthesis	-LSB- Inhibitory effect of artemin on endotoxin-induced nitric_oxide synthesis -RSB- .
11231040	0	nitric_oxide	10,22	atrial_natriuretic_factor	63,88	nitric oxide	atrial natriuretic factor	MESH:D009569	24602(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of nitric_oxide on basal and stretch-induced release of atrial_natriuretic_factor -LRB- ANF -RRB- from isolated perfused rat atria .
8769765	0	nitric_oxide	10,22	atrial_natriuretic_factor	50,75	nitric oxide	atrial natriuretic factor	MESH:D009569	24602(Tax:10116)	Chemical	Gene	inhibition|amod|START_ENTITY Effect|nmod|inhibition Effect|nmod|END_ENTITY	Effect of nitric_oxide inhibition on secretion of atrial_natriuretic_factor in isolated rat heart .
10795869	0	nitric_oxide	85,97	atrial_natriuretic_peptide	25,51	nitric oxide	atrial natriuretic peptide	MESH:D009569	608289(Tax:9615)	Chemical	Gene	START_ENTITY|nsubj|study study|nmod|levels levels|amod|END_ENTITY	An experimental study of atrial_natriuretic_peptide levels and the effect of inhaled nitric_oxide after pneumonectomy .
10945935	0	nitric_oxide	11,23	atrial_natriuretic_peptide	52,78	nitric oxide	atrial natriuretic peptide	MESH:D009569	24602(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY Effects|nmod|synthesis inhibition|nsubj|Effects inhibition|nmod|system system|amod|END_ENTITY	Effects of nitric_oxide synthesis inhibition on the atrial_natriuretic_peptide system .
11168617	0	nitric_oxide	75,87	atrial_natriuretic_peptide	102,128	nitric oxide	atrial natriuretic peptide	MESH:D009569	230899(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY inhibition|nmod|production contributes|nmod|inhibition contributes|nmod|END_ENTITY	Elevation of intracellular calcium levels contributes to the inhibition of nitric_oxide production by atrial_natriuretic_peptide .
11231039	0	nitric_oxide	8,20	atrial_natriuretic_peptide	24,50	nitric oxide	atrial natriuretic peptide	MESH:D009569	24602(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|release release|amod|END_ENTITY	Role of nitric_oxide on atrial_natriuretic_peptide release induced by angiotensin_II in superfused rat atrial tissue .
12450070	0	nitric_oxide	8,20	atrial_natriuretic_peptide	51,77	nitric oxide	atrial natriuretic peptide	MESH:D009569	100009087(Tax:9986)	Chemical	Gene	START_ENTITY|nmod|effect effect|nmod|END_ENTITY	Role of nitric_oxide on the vasorelaxant effect of atrial_natriuretic_peptide on rabbit aorta basal tone .
14700747	0	nitric_oxide	24,36	atrial_natriuretic_peptide	71,97	nitric oxide	atrial natriuretic peptide	MESH:D009569	24602(Tax:10116)	Chemical	Gene	inhibition|amod|START_ENTITY induced|nmod|inhibition Hypertension|acl|induced activates|nsubj|Hypertension activates|dobj|system system|compound|END_ENTITY	Hypertension induced by nitric_oxide synthase inhibition activates the atrial_natriuretic_peptide -LRB- ANP -RRB- system .
16712979	0	nitric_oxide	38,50	atrial_natriuretic_peptide	80,106	nitric oxide	atrial natriuretic peptide	MESH:D009569	24602(Tax:10116)	Chemical	Gene	activation|amod|START_ENTITY receptor|nmod|activation Role|nmod|receptor induced|nsubj|Role induced|nmod|END_ENTITY	Role of NPR-C natriuretic receptor in nitric_oxide system activation induced by atrial_natriuretic_peptide .
17223208	0	nitric_oxide	31,43	atrial_natriuretic_peptide	56,82	nitric oxide	atrial natriuretic peptide	MESH:D009569	24602(Tax:10116)	Chemical	Gene	Participation|nmod|START_ENTITY synthase|nsubj|Participation synthase|nmod|concentration concentration|amod|END_ENTITY	Participation of the inducible nitric_oxide synthase on atrial_natriuretic_peptide plasma concentration during endotoxemic_shock .
17537544	0	nitric_oxide	85,97	atrial_natriuretic_peptide	57,83	nitric oxide	atrial natriuretic peptide	MESH:D009569	24602(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY synthase|dep|END_ENTITY	Neonatal oxytocin treatment modulates oxytocin receptor , atrial_natriuretic_peptide , nitric_oxide synthase and estrogen receptor mRNAs expression in rat heart .
19179430	0	nitric_oxide	107,119	atrial_natriuretic_peptide	71,97	nitric oxide	atrial natriuretic peptide	MESH:D009569	230899(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY regulation|dep|role regulation|nmod|pressure pressure|nmod|END_ENTITY	Chronic endothelium-dependent regulation of arterial blood pressure by atrial_natriuretic_peptide : role of nitric_oxide and endothelin-1 .
19783776	0	nitric_oxide	8,20	atrial_natriuretic_peptide	68,94	nitric oxide	atrial natriuretic peptide	MESH:D009569	24602(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|rats rats|amod|END_ENTITY	Role of nitric_oxide as a key mediator on cardiovascular actions of atrial_natriuretic_peptide in spontaneously hypertensive rats .
22378819	0	nitric_oxide	92,104	atrial_natriuretic_peptide	17,43	nitric oxide	atrial natriuretic peptide	MESH:D009569	24602(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY actions|dep|role actions|nmod|rats rats|amod|END_ENTITY	Renal actions of atrial_natriuretic_peptide in spontaneously hypertensive rats : the role of nitric_oxide as a key mediator .
24953240	0	nitric_oxide	126,138	atrial_natriuretic_peptide	8,34	nitric oxide	atrial natriuretic peptide	MESH:D009569	24602(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY elicited|nmod|inhibition elicited|nsubj|Role Role|nmod|natriuresis natriuresis|amod|END_ENTITY	Role of atrial_natriuretic_peptide in mediating the blood pressure-independent natriuresis elicited by systemic inhibition of nitric_oxide .
12727317	0	nitric_oxide	9,21	bNOS	32,36	nitric oxide	bNOS	MESH:D009569	24598(Tax:10116)	Chemical	Gene	synthase|nsubj|START_ENTITY synthase|xcomp|RNA RNA|dep|END_ENTITY	Neuronal nitric_oxide synthase -LRB- bNOS -RRB- messenger RNA and protein expression in developing rat brainstem nuclei .
12812776	0	nitric_oxide	37,49	bNOS	60,64	nitric oxide	bNOS	MESH:D009569	4842	Chemical	Gene	form|nmod|START_ENTITY Localization|nmod|form synthase|nsubj|Localization synthase|dobj|END_ENTITY	Localization of the neuronal form of nitric_oxide synthase -LRB- bNOS -RRB- in the diencephalon and pituitary gland of the catfish , Synodontis multipunctatus : an immunocytochemical study .
15232775	0	nitric_oxide	37,49	bNOS	60,64	nitric oxide	bNOS	MESH:D009569	24598(Tax:10116)	Chemical	Gene	studies|nmod|START_ENTITY synthase|nsubj|studies synthase|dobj|END_ENTITY	Immunohistochemical studies on brain nitric_oxide synthase -LRB- bNOS -RRB- in the male genital accessory glands of the rat during postnatal development .
15255297	0	nitric_oxide	91,103	bNOS	114,118	nitric oxide	bNOS	MESH:D009569	4842	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Cytochemical correlates of the sleep-wake interface : concerted expression of brain-derived nitric_oxide synthase -LRB- bNOS -RRB- and the nicotinic_acetylcholine_receptor -LRB- nAChR -RRB- in a columnoid organization of the primate prefrontal cortex .
17502619	0	nitric_oxide	30,42	beta-Actin	0,10	nitric oxide	beta-Actin	MESH:D009569	728378	Chemical	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	beta-Actin regulates platelet nitric_oxide synthase 3 activity through interaction with heat_shock_protein_90 .
15517355	0	nitric_oxide	36,48	beta-amylase	20,32	nitric oxide	beta-amylase	MESH:D009569	542896(Tax:4565)	Chemical	Gene	response|acl|START_ENTITY response|nmod|END_ENTITY	A rapid response of beta-amylase to nitric_oxide but not gibberellin in wheat seeds during the early stage of germination .
10377076	0	nitric_oxide	104,116	bradykinin	38,48	nitric oxide	bradykinin	MESH:D009569	3827	Chemical	Gene	+|amod|START_ENTITY contribution|nmod|+ depends|dobj|contribution depends|nsubj|coronary_arteriolar_dilation coronary_arteriolar_dilation|nmod|END_ENTITY	Human coronary_arteriolar_dilation to bradykinin depends on membrane hyperpolarization : contribution of nitric_oxide and Ca2 + - activated K + channels .
10500040	0	nitric_oxide	112,124	bradykinin	16,26	nitric oxide	bradykinin	MESH:D009569	3827	Chemical	Gene	availability|amod|START_ENTITY mechanism|nmod|availability mediated|nmod|mechanism mediated|nsubjpass|Vasodilation Vasodilation|nmod|END_ENTITY	Vasodilation to bradykinin is mediated by an ouabain-sensitive pathway as a compensatory mechanism for impaired nitric_oxide availability in essential hypertensive patients .
12489789	0	nitric_oxide	45,57	bradykinin	81,91	nitric oxide	bradykinin	MESH:D009569	3827	Chemical	Gene	mechanisms|nmod|START_ENTITY synthase|nsubj|mechanisms synthase|nmod|END_ENTITY	Post-translational mechanisms of endothelial nitric_oxide synthase regulation by bradykinin .
12821139	0	nitric_oxide	30,42	bradykinin	57,67	nitric oxide	bradykinin	MESH:D009569	280833(Tax:9913)	Chemical	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Rapid increase in endothelial nitric_oxide production by bradykinin is mediated by protein kinase A signaling pathway .
1334350	0	nitric_oxide	52,64	bradykinin	156,166	nitric oxide	bradykinin	MESH:D009569	280833(Tax:9913)	Chemical	Gene	formation|nmod|START_ENTITY Converting|dobj|formation mediated|csubjpass|Converting mediated|nmod|END_ENTITY	Converting enzyme inhibitor-stimulated formation of nitric_oxide and prostacyclin in endothelial cells from bovine aorta is mediated by endothelium-derived bradykinin .
14514933	0	nitric_oxide	61,73	bradykinin	10,20	nitric oxide	bradykinin	MESH:D009569	3827	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Effect Effect|nmod|END_ENTITY	Effect of bradykinin on allergen induced increase in exhaled nitric_oxide in asthma .
2043304	0	nitric_oxide	38,50	bradykinin	98,108	nitric oxide	bradykinin	MESH:D009569	478666(Tax:9615)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Mediatory role of endothelium-derived nitric_oxide in renal vasodilatory and excretory effects of bradykinin .
22507330	0	nitric_oxide	8,20	bradykinin	92,102	nitric oxide	bradykinin	MESH:D009569	3827	Chemical	Gene	related|nsubjpass|START_ENTITY related|xcomp|END_ENTITY	Exhaled nitric_oxide is related to bronchial eosinophilia and airway hyperresponsiveness to bradykinin in allergen-induced asthma exacerbation .
23729620	0	nitric_oxide	55,67	bradykinin	24,34	nitric oxide	bradykinin	MESH:D009569	280833(Tax:9913)	Chemical	Gene	activation|compound|START_ENTITY enhances|nmod|activation enhances|dobj|relaxations relaxations|compound|END_ENTITY	ACE inhibition enhances bradykinin relaxations through nitric_oxide and B1 receptor activation in bovine coronary arteries .
24265812	0	nitric_oxide	30,42	bradykinin	44,54	nitric oxide	bradykinin	MESH:D009569	3827	Chemical	Gene	concentration|amod|START_ENTITY concentration|amod|END_ENTITY	Type_2_diabetes_elicits lower nitric_oxide , bradykinin concentration and kallikrein activity together with higher DesArg -LRB- 9 -RRB- - BK and reduced post-exercise hypotension compared to non-diabetic_condition .
7514511	0	nitric_oxide	91,103	bradykinin	40,50	nitric oxide	bradykinin	MESH:D009569	3827	Chemical	Gene	synthase|compound|START_ENTITY activation|nmod|synthase sustains|dobj|activation sustains|nsubj|alkalinization alkalinization|acl|induced induced|nmod|END_ENTITY	Intracellular alkalinization induced by bradykinin sustains activation of the constitutive nitric_oxide synthase in endothelial cells .
7659783	0	nitric_oxide	34,46	bradykinin	2,12	nitric oxide	bradykinin	MESH:D009569	3827	Chemical	Gene	generation|amod|START_ENTITY inhibited|dobj|generation inhibited|nsubj|antagonist antagonist|compound|END_ENTITY	A bradykinin antagonist inhibited nitric_oxide generation and thromboxane biosynthesis in acute pancreatitis .
8695758	0	nitric_oxide	71,83	bradykinin	40,50	nitric oxide	bradykinin	MESH:D009569	478666(Tax:9615)	Chemical	Gene	production|amod|START_ENTITY inhibition|nmod|production END_ENTITY|nmod|inhibition	Methylene_blue restores vasodilation to bradykinin after inhibition of nitric_oxide production in the isolated dog lung .
8818341	0	nitric_oxide	89,101	bradykinin	47,57	nitric oxide	bradykinin	MESH:D009569	3827	Chemical	Gene	synthase|amod|START_ENTITY inhibitors|nmod|synthase END_ENTITY|nmod|inhibitors	Attenuation of human nasal airway responses to bradykinin and histamine by inhibitors of nitric_oxide synthase .
8856164	0	nitric_oxide	36,48	bradykinin	52,62	nitric oxide	bradykinin	MESH:D009569	3827	Chemical	Gene	Biosynthesis|nmod|START_ENTITY Biosynthesis|nmod|END_ENTITY	Biosynthesis of endothelium-derived nitric_oxide by bradykinin as endogenous precursor .
8869130	0	nitric_oxide	43,55	bradykinin	66,76	nitric oxide	bradykinin	MESH:D009569	3827	Chemical	Gene	mediators|compound|START_ENTITY mediators|compound|END_ENTITY	Maintenance of vascular integrity : role of nitric_oxide and other bradykinin mediators .
9138678	0	nitric_oxide	54,66	bradykinin	111,121	nitric oxide	bradykinin	MESH:D009569	3827	Chemical	Gene	mechanisms|nmod|START_ENTITY mediate|nsubj|mechanisms mediate|dobj|relaxation relaxation|acl|END_ENTITY	Evidence that mechanisms dependent and independent of nitric_oxide mediate endothelium-dependent relaxation to bradykinin in human small resistance-like coronary arteries .
9235967	0	nitric_oxide	88,100	bradykinin	14,24	nitric oxide	bradykinin	MESH:D009569	3827	Chemical	Gene	ligand|nmod|START_ENTITY ligand|nsubj|Modulation Modulation|nmod|receptor receptor|compound|END_ENTITY	Modulation of bradykinin receptor ligand binding affinity and its coupled G-proteins by nitric_oxide .
10780834	0	nitric_oxide	10,22	c-Fos	47,52	nitric oxide	c-Fos	MESH:D009569	314322(Tax:10116)	Chemical	Gene	inhibition|amod|START_ENTITY Effect|nmod|inhibition Effect|nmod|expression expression|amod|END_ENTITY	Effect of nitric_oxide synthesis inhibition on c-Fos expression in hippocampus and cerebral cortex following two forms of learning in rats : an immunohistochemistry study .
11275410	0	nitric_oxide	15,27	c-Fos	48,53	nitric oxide	c-Fos	MESH:D009569	314322(Tax:10116)	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|expression expression|amod|END_ENTITY	Involvement of nitric_oxide in morphine-induced c-Fos expression in the rat striatum .
8593586	0	nitric_oxide	52,64	c-Fos	99,104	nitric oxide	c-Fos	MESH:D009569	314322(Tax:10116)	Chemical	Gene	synthase|compound|START_ENTITY inhibitor|nmod|synthase 7-Nitro-indazole|appos|inhibitor reduces|nsubj|7-Nitro-indazole reduces|ccomp|evoked evoked|dobj|expression expression|amod|END_ENTITY	7-Nitro-indazole , a selective inhibitor of neuronal nitric_oxide synthase , reduces formalin evoked c-Fos expression in dorsal horn neurons of the rat spinal cord .
8593586	1	nitric_oxide	247,259	c-Fos	323,328	nitric oxide	c-Fos	MESH:D009569	314322(Tax:10116)	Chemical	Gene	synthase|compound|START_ENTITY inhibitor|nmod|synthase 7-nitro-indazole|appos|inhibitor effect|nmod|7-nitro-indazole evoked|nsubj|effect evoked|ccomp|studied studied|nsubjpass|expression expression|nmod|END_ENTITY	The effect of intravenous 7-nitro-indazole -LRB- 7NI -RRB- , a selective inhibitor of neuronal nitric_oxide synthase , on intraplantar formalin evoked spinal expression of c-Fos was studied .
18565207	0	nitric_oxide	10,22	c-Jun_N-terminal_kinase	44,67	nitric oxide	c-Jun N-terminal kinase	MESH:D009569	116554(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|amod|END_ENTITY	Exogenous nitric_oxide negatively regulates c-Jun_N-terminal_kinase activation via inhibiting endogenous NO-induced S-nitrosylation during cerebral_ischemia and reperfusion in rat hippocampus .
11583916	0	nitric_oxide	66,78	c-Src	28,33	nitric oxide	c-Src	MESH:D009569	6714	Chemical	Gene	action|nmod|START_ENTITY END_ENTITY|nmod|action	Evidence for involvement of c-Src in the anti-apoptotic action of nitric_oxide in serum-deprived RINm5F cells .
10648884	0	nitric_oxide	156,168	c-fos	99,104	nitric oxide	c-fos	MESH:D009569	314322(Tax:10116)	Chemical	Gene	modulation|nmod|START_ENTITY calcium|dep|modulation contributes|nmod|calcium contributes|nmod|expression expression|amod|END_ENTITY	Calmodulin-dependent activation of p38 and p42/44 mitogen-activated protein kinases contributes to c-fos expression by calcium in PC12 cells : modulation by nitric_oxide .
11069127	0	nitric_oxide	87,99	c-fos	16,21	nitric oxide	c-fos	MESH:D009569	314322(Tax:10116)	Chemical	Gene	injection|nmod|START_ENTITY Distribution|nmod|injection Distribution|nmod|mRNA mRNA|amod|END_ENTITY	Distribution of c-fos mRNA in the brain following intracerebroventricular injection of nitric_oxide -LRB- NO -RRB- - releasing compounds : possible role of NO in central cardiovascular regulation .
11146065	0	nitric_oxide	15,27	c-fos	54,59	nitric oxide	c-fos	MESH:D009569	314322(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	How central is nitric_oxide -LRB- NO -RRB- to the activation of c-fos in spinal neurones following noxious peripheral stimulation in the rat ?
7519434	0	nitric_oxide	37,49	c-fos	103,108	nitric oxide	c-fos	MESH:D009569	2353	Chemical	Gene	synthase|compound|START_ENTITY expression|nmod|synthase induces|nsubj|expression induces|dobj|END_ENTITY	Constitutive expression of inducible nitric_oxide synthase in human bronchial epithelial cells induces c-fos and stimulates the cGMP pathway .
7535406	0	nitric_oxide	25,37	c-fos	138,143	nitric oxide	c-fos	MESH:D009569	314322(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY expression|amod|synthase development|nmod|expression development|dep|comparison comparison|nmod|induction induction|nmod|END_ENTITY	Postnatal development of nitric_oxide synthase type 1 expression in the lumbar spinal cord of the rat : a comparison with the induction of c-fos in response to peripheral application of mustard oil .
9070740	0	nitric_oxide	12,24	c-fos	63,68	nitric oxide	c-fos	MESH:D009569	314322(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY Blockers|nmod|synthase inhibit|nsubj|Blockers inhibit|dobj|activation activation|nmod|expression expression|amod|END_ENTITY	Blockers of nitric_oxide synthase inhibit stress activation of c-fos expression in neurons of the hypothalamic paraventricular nucleus in the rat .
12363386	0	nitric_oxide	41,53	cNOS	64,68	nitric oxide	cNOS	MESH:D009569	4846	Chemical	Gene	START_ENTITY|dobj|activity activity|appos|END_ENTITY	Decreased calcium-dependent constitutive nitric_oxide synthase -LRB- cNOS -RRB- activity in prefrontal cortex in schizophrenia and depression .
9229076	0	nitric_oxide	46,58	cNOS	69,73	nitric oxide	cNOS	MESH:D009569	24600(Tax:10116)	Chemical	Gene	demonstration|nmod|START_ENTITY synthase|nsubj|demonstration synthase|dobj|END_ENTITY	Ultrastructural demonstration of constitutive nitric_oxide synthase -LRB- cNOS -RRB- in neocortical glial cells and glial perisynaptic sheaths .
10233692	0	nitric_oxide	8,20	calcitonin_gene-related_peptide	71,102	nitric oxide	calcitonin gene-related peptide	MESH:D009569	12310(Tax:10090)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|effects effects|nmod|macrophages macrophages|amod|END_ENTITY	Role of nitric_oxide and prostaglandins in the potentiating effects of calcitonin_gene-related_peptide on lipopolysaccharide-induced interleukin-6 release from mouse peritoneal macrophages .
11324537	0	nitric_oxide	113,125	calcitonin_gene-related_peptide	13,44	nitric oxide	calcitonin gene-related peptide	MESH:D009569	24241(Tax:10116)	Chemical	Gene	-RSB-|amod|START_ENTITY Decrease|nmod|-RSB- Decrease|nmod|release release|amod|END_ENTITY	-LSB- Decrease of calcitonin_gene-related_peptide release from mesenteric arterial bed in diabetic rats and effect of nitric_oxide -RSB- .
12047464	0	nitric_oxide	36,48	calcitonin_gene-related_peptide	67,98	nitric oxide	calcitonin gene-related peptide	MESH:D009569	24241(Tax:10116)	Chemical	Gene	Increase|nmod|START_ENTITY Increase|dep|interaction interaction|nmod|receptor receptor|amod|END_ENTITY	Increase in meningeal blood flow by nitric_oxide -- interaction with calcitonin_gene-related_peptide receptor and prostaglandin synthesis inhibition .
15464099	0	nitric_oxide	104,116	calcitonin_gene-related_peptide	64,95	nitric oxide	calcitonin gene-related peptide	MESH:D009569	24241(Tax:10116)	Chemical	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	Delayed preconditioning by cardiac_ischemia involves endogenous calcitonin_gene-related_peptide via the nitric_oxide pathway .
16216959	0	nitric_oxide	8,20	calcitonin_gene-related_peptide	64,95	nitric oxide	calcitonin gene-related peptide	MESH:D009569	100294596(Tax:9940)	Chemical	Gene	START_ENTITY|acl|mediating mediating|xcomp|END_ENTITY	Role of nitric_oxide in mediating in vivo vascular responses to calcitonin_gene-related_peptide in essential and peripheral circulations in the fetus .
18782573	0	nitric_oxide	139,151	calcitonin_gene-related_peptide	41,72	nitric oxide	calcitonin gene-related peptide	MESH:D009569	24241(Tax:10116)	Chemical	Gene	inhibitors|amod|START_ENTITY role|nmod|inhibitors Decrease|dep|role Decrease|nmod|synthesis synthesis|nmod|END_ENTITY	Decrease in the synthesis and release of calcitonin_gene-related_peptide in dorsal root ganglia of spontaneously hypertensive rat : role of nitric_oxide synthase inhibitors .
19520131	0	nitric_oxide	65,77	calcitonin_gene-related_peptide	18,49	nitric oxide	calcitonin gene-related peptide	MESH:D009569	796	Chemical	Gene	pathway|amod|START_ENTITY expression|nmod|pathway expression|amod|END_ENTITY	Clonidine induces calcitonin_gene-related_peptide expression via nitric_oxide pathway in endothelial cells .
21391919	0	nitric_oxide	45,57	calcitonin_gene-related_peptide	10,41	nitric oxide	calcitonin gene-related peptide	MESH:D009569	796	Chemical	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	Effect of calcitonin_gene-related_peptide on nitric_oxide production in osteoblasts : an experimental study .
7835100	0	nitric_oxide	15,27	calcitonin_gene-related_peptide	71,102	nitric oxide	calcitonin gene-related peptide	MESH:D009569	24241(Tax:10116)	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|effect effect|nmod|END_ENTITY	Involvement of nitric_oxide in the vasodilator and depressor effect of calcitonin_gene-related_peptide .
8050460	0	nitric_oxide	11,23	calcitonin_gene-related_peptide	54,85	nitric oxide	calcitonin gene-related peptide	MESH:D009569	796	Chemical	Gene	role|nmod|START_ENTITY role|nmod|activity activity|nmod|END_ENTITY	A role for nitric_oxide in the anti-ulcer activity of calcitonin_gene-related_peptide .
8170522	0	nitric_oxide	25,37	calcitonin_gene-related_peptide	157,188	nitric oxide	calcitonin gene-related peptide	MESH:D009569	24241(Tax:10116)	Chemical	Gene	Nitroglycerin|dep|START_ENTITY substitutes|amod|Nitroglycerin induced|nsubj|substitutes induced|nmod|END_ENTITY	Nitroglycerin -LRB- exogenous nitric_oxide -RRB- substitutes for endothelium-derived nitric_oxide in potentiating vasorelaxations and cyclic_AMP elevations induced by calcitonin_gene-related_peptide -LRB- CGRP -RRB- in rat aorta .
8170522	0	nitric_oxide	75,87	calcitonin_gene-related_peptide	157,188	nitric oxide	calcitonin gene-related peptide	MESH:D009569	24241(Tax:10116)	Chemical	Gene	substitutes|nmod|START_ENTITY induced|nsubj|substitutes induced|nmod|END_ENTITY	Nitroglycerin -LRB- exogenous nitric_oxide -RRB- substitutes for endothelium-derived nitric_oxide in potentiating vasorelaxations and cyclic_AMP elevations induced by calcitonin_gene-related_peptide -LRB- CGRP -RRB- in rat aorta .
8884978	0	nitric_oxide	76,88	calcitonin_gene-related_peptide	43,74	nitric oxide	calcitonin gene-related peptide	MESH:D009569	796	Chemical	Gene	metabolites|amod|START_ENTITY metabolites|amod|END_ENTITY	Relationship between circulating levels of calcitonin_gene-related_peptide , nitric_oxide metabolites and hemodynamic changes in human septic_shock .
9389177	0	nitric_oxide	14,26	calcitonin_gene-related_peptide	82,113	nitric oxide	calcitonin gene-related peptide	MESH:D009569	24241(Tax:10116)	Chemical	Gene	roles|nmod|START_ENTITY -LSB-|dobj|roles -LSB-|nmod|release release|nmod|END_ENTITY	-LSB- The roles of nitric_oxide and prostaglandins in the endotoxin-induced release of calcitonin_gene-related_peptide -LRB- CGRP -RRB- in rat mesenteric artery -RSB- .
8839053	0	nitric_oxide	62,74	calmodulin	27,37	nitric oxide	calmodulin	MESH:D009569	808	Chemical	Gene	stimulation|nmod|START_ENTITY stimulation|compound|END_ENTITY	Peroxynitrite reduction of calmodulin stimulation of neuronal nitric_oxide synthase .
10320003	0	nitric_oxide	45,57	caspase-3	66,75	nitric oxide	caspase-3	MESH:D009569	25402(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY induced|nsubj|receptors induced|dobj|activity activity|amod|END_ENTITY	Group I metabotropic receptors down-regulate nitric_oxide induced caspase-3 activity in rat hippocampal neurons .
10728388	0	nitric_oxide	25,37	caspase-3	115,124	nitric oxide	caspase-3	MESH:D009569	25402(Tax:10116)	Chemical	Gene	synthase|compound|START_ENTITY Inhibition|nmod|synthase potentiates|nsubj|Inhibition potentiates|dobj|myocardial_apoptosis myocardial_apoptosis|nmod|pathway pathway|amod|dependent dependent|amod|END_ENTITY	Inhibition of endogenous nitric_oxide synthase potentiates ischemia-reperfusion-induced myocardial_apoptosis via a caspase-3 dependent pathway .
12938857	0	nitric_oxide	107,119	caspase-3	16,25	nitric oxide	caspase-3	MESH:D009569	836	Chemical	Gene	role|nmod|START_ENTITY activation|dep|role activation|amod|END_ENTITY	Hypoxia-induced caspase-3 activation and DNA fragmentation in cortical neurons of newborn piglets : role of nitric_oxide .
25139733	0	nitric_oxide	15,27	caspase-3	57,66	nitric oxide	caspase-3	MESH:D009569	25402(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|production production|nmod|death death|amod|END_ENTITY	NF-kB-mediated nitric_oxide production and activation of caspase-3 cause retinal_ganglion cell death in the hypoxic_neonatal_retina .
9299518	0	nitric_oxide	65,77	caspase-3	14,23	nitric oxide	caspase-3	MESH:D009569	836	Chemical	Gene	caused|nmod|START_ENTITY caused|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of caspase-3 by S-nitrosation and oxidation caused by nitric_oxide .
10769006	0	nitric_oxide	46,58	catalase	28,36	nitric oxide	catalase	MESH:D009569	12359(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY inhibits|dobj|production inhibits|nsubj|preparation preparation|nmod|END_ENTITY	A commercial preparation of catalase inhibits nitric_oxide production by activated murine macrophages : role of arginase .
16112416	0	nitric_oxide	137,149	catalase	51,59	nitric oxide	catalase	MESH:D009569	847	Chemical	Gene	oxidase|advmod|START_ENTITY oxidase|amod|END_ENTITY	Glutathione peroxidase , glutathione-S-transferase , catalase , xanthine oxidase , Cu-Zn_superoxide dismutase activities , total glutathione , nitric_oxide , and malondialdehyde levels in erythrocytes of patients with small cell and non-small_cell_lung_cancer .
19897742	0	nitric_oxide	24,36	catalase	106,114	nitric oxide	catalase	MESH:D009569	847	Chemical	Gene	START_ENTITY|xcomp|signaling signaling|nmod|cells cells|nmod|reduction reduction|nmod|activity activity|amod|END_ENTITY	Shear stress stimulates nitric_oxide signaling in pulmonary arterial endothelial cells via a reduction in catalase activity : role of protein_kinase_C_delta .
24087936	0	nitric_oxide	26,38	catalase	9,17	nitric oxide	catalase	MESH:D009569	847	Chemical	Gene	START_ENTITY|nsubj|release release|amod|END_ENTITY	How does catalase release nitric_oxide ?
8614253	0	nitric_oxide	4,16	catalase	85,93	nitric oxide	catalase	MESH:D009569	847	Chemical	Gene	NW-nitro-L-arginine_methylester|amod|START_ENTITY attenuates|nsubj|NW-nitro-L-arginine_methylester attenuates|dobj|activity activity|compound|END_ENTITY	The nitric_oxide synthase inhibitor NW-nitro-L-arginine_methylester attenuates brain catalase activity in vitro .
9192093	0	nitric_oxide	75,87	catalase	40,48	nitric oxide	catalase	MESH:D009569	12359(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY expression|nmod|production expression|nsubj|Influence Influence|nmod|gene gene|amod|END_ENTITY	Influence of Mycobacterium_tuberculosis catalase gene -LRB- KatG -RRB- expression on nitric_oxide production and the intracellular growth of transfected Mycobacterium_smegmatis strains within murine macrophages .
10705178	0	nitric_oxide	25,37	cholecystokinin	57,72	nitric oxide	cholecystokinin	MESH:D009569	100735029	Chemical	Gene	release|amod|START_ENTITY monitoring|nmod|release induced|nsubj|monitoring induced|nmod|END_ENTITY	Continuous monitoring of nitric_oxide release induced by cholecystokinin from the choledochal sphincter in guinea_pigs .
8897884	0	nitric_oxide	58,70	cholecystokinin	14,29	nitric oxide	cholecystokinin	MESH:D009569	885	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of cholecystokinin secretion in STC-1 cells by nitric_oxide .
23834774	0	nitric_oxide	12,24	choline_acetyltransferase	101,126	nitric oxide	choline acetyltransferase	MESH:D009569	290567(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY role|dep|involvement involvement|nmod|END_ENTITY	The role of nitric_oxide in the PKA inhibitor induced spatial memory_deficits in rat : involvement of choline_acetyltransferase .
7768270	0	nitric_oxide	23,35	corticotropin-releasing_factor	43,73	nitric oxide	corticotropin-releasing factor	MESH:D009569	81648(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|release release|amod|END_ENTITY	Evidence for a role of nitric_oxide in the corticotropin-releasing_factor release induced by interleukin-1_beta .
8821744	0	nitric_oxide	74,86	corticotropin-releasing_factor	113,143	nitric oxide	corticotropin-releasing factor	MESH:D009569	81648(Tax:10116)	Chemical	Gene	synthase|compound|START_ENTITY expression|nmod|synthase expression|dep|comparison comparison|nmod|transcripts transcripts|compound|END_ENTITY	Systemic endotoxin increases steady-state gene expression of hypothalamic nitric_oxide synthase : comparison with corticotropin-releasing_factor and vasopressin gene transcripts .
11085902	0	nitric_oxide	147,159	corticotropin-releasing_hormone	50,81	nitric oxide	corticotropin-releasing hormone	MESH:D009569	81648(Tax:10116)	Chemical	Gene	involvement|nmod|START_ENTITY effect|dep|involvement effect|nmod|END_ENTITY	Stimulating effect of HIV-1 coat protein gp120 on corticotropin-releasing_hormone and arginine_vasopressin in the rat hypothalamus : involvement of nitric_oxide .
11854458	0	nitric_oxide	17,29	corticotropin-releasing_hormone	91,122	nitric oxide	corticotropin-releasing hormone	MESH:D009569	1392	Chemical	Gene	synthase|amod|START_ENTITY Up-regulation|nmod|synthase Up-regulation|nmod|activity activity|nmod|END_ENTITY	Up-regulation of nitric_oxide synthase and modulation of the guanylate cyclase activity by corticotropin-releasing_hormone but not urocortin_II or urocortin_III in cultured human pregnant myometrial cells .
9655478	0	nitric_oxide	138,150	corticotropin-releasing_hormone	54,85	nitric oxide	corticotropin-releasing hormone	MESH:D009569	81648(Tax:10116)	Chemical	Gene	generation|nmod|START_ENTITY regulating|nmod|generation regulating|dobj|release release|amod|END_ENTITY	Endotoxin stimulates an endogenous pathway regulating corticotropin-releasing_hormone and vasopressin release involving the generation of nitric_oxide and carbon_monoxide .
9889372	0	nitric_oxide	27,39	corticotropin-releasing_hormone	54,85	nitric oxide	corticotropin-releasing hormone	MESH:D009569	81648(Tax:10116)	Chemical	Gene	effect|amod|START_ENTITY effect|nmod|END_ENTITY	Social stress inhibits the nitric_oxide effect on the corticotropin-releasing_hormone - but not vasopressin-induced pituitary-adrenocortical responsiveness .
11606324	0	nitric_oxide	73,85	corticotropin_releasing_hormone	21,52	nitric oxide	corticotropin releasing hormone	MESH:D009569	12918(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY END_ENTITY|nmod|synthase	Divergent effects of corticotropin_releasing_hormone on endothelial cell nitric_oxide synthase are associated with different expression of CRH type 1 and 2 receptors .
17382773	0	nitric_oxide	43,55	cyclooxygenase-1_and_2	66,88	nitric oxide	cyclooxygenase-1 and 2	MESH:D009569	24693;29527	Chemical	Gene	role|nmod|START_ENTITY role|amod|END_ENTITY	Cyclophosphamide induced cystitis : role of nitric_oxide synthase , cyclooxygenase-1_and_2 , and NK -LRB- 1 -RRB- _ receptors .
10232679	0	nitric_oxide	15,27	cyclooxygenase-2	38,54	nitric oxide	cyclooxygenase-2	MESH:D009569	5743	Chemical	Gene	donors|amod|START_ENTITY effect|nmod|donors effect|nmod|expression expression|amod|END_ENTITY	Dual effect of nitric_oxide donors on cyclooxygenase-2 expression in human mesangial cells .
10380901	0	nitric_oxide	12,24	cyclooxygenase-2	50,66	nitric oxide	cyclooxygenase-2	MESH:D009569	19225(Tax:10090)	Chemical	Gene	down-regulates|amod|START_ENTITY Blockade|nmod|down-regulates END_ENTITY|nsubj|Blockade	Blockade of nitric_oxide formation down-regulates cyclooxygenase-2 and decreases PGE2 biosynthesis in macrophages .
10975859	0	nitric_oxide	68,80	cyclooxygenase-2	151,167	nitric oxide	cyclooxygenase-2	MESH:D009569	5743	Chemical	Gene	chondrocytes|nmod|START_ENTITY death|nmod|chondrocytes induction|nmod|death related|nsubjpass|induction related|nmod|production production|nmod|prostaglandin_E2 prostaglandin_E2|nmod|induction induction|nmod|END_ENTITY	The induction of cell death in human osteoarthritis chondrocytes by nitric_oxide is related to the production of prostaglandin_E2 via the induction of cyclooxygenase-2 .
11396478	0	nitric_oxide	45,57	cyclooxygenase-2	14,30	nitric oxide	cyclooxygenase-2	MESH:D009569	5743	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of cyclooxygenase-2 expression by nitric_oxide in cells .
11875313	0	nitric_oxide	18,30	cyclooxygenase-2	47,63	nitric oxide	cyclooxygenase-2	MESH:D009569	29527(Tax:10116)	Chemical	Gene	accumulation|amod|START_ENTITY accumulation|nmod|induction induction|amod|END_ENTITY	Downregulation of nitric_oxide accumulation by cyclooxygenase-2 induction and thromboxane_A2 production in interleukin-1beta-stimulated rat aortic smooth muscle cells .
11909825	0	nitric_oxide	10,22	cyclooxygenase-2	42,58	nitric oxide	cyclooxygenase-2	MESH:D009569	100009248(Tax:9986)	Chemical	Gene	synthase|compound|START_ENTITY modulates|nsubj|synthase modulates|dobj|activity activity|amod|END_ENTITY	Inducible nitric_oxide synthase modulates cyclooxygenase-2 activity in the heart of conscious rabbits during the late phase of ischemic preconditioning .
12468265	0	nitric_oxide	46,58	cyclooxygenase-2	15,31	nitric oxide	cyclooxygenase-2	MESH:D009569	19225(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Suppression of cyclooxygenase-2 and inducible nitric_oxide synthase expression by conjugated linoleic_acid in murine macrophages .
12573534	0	nitric_oxide	33,45	cyclooxygenase-2	70,86	nitric oxide	cyclooxygenase-2	MESH:D009569	5743	Chemical	Gene	START_ENTITY|dobj|cells cells|amod|END_ENTITY	Hypothermia suppresses inducible nitric_oxide synthase and stimulates cyclooxygenase-2 in lipopolysaccharide stimulated BV-2 cells .
14566822	0	nitric_oxide	14,26	cyclooxygenase-2	30,46	nitric oxide	cyclooxygenase-2	MESH:D009569	5743	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|overexpression overexpression|amod|END_ENTITY	The effect of nitric_oxide on cyclooxygenase-2 -LRB- COX-2 -RRB- overexpression in head_and_neck_cancer cell lines .
14633677	0	nitric_oxide	49,61	cyclooxygenase-2	103,119	nitric oxide	cyclooxygenase-2	MESH:D009569	5743	Chemical	Gene	cells|nmod|START_ENTITY inhibition|nmod|cells associated|nsubjpass|inhibition associated|nmod|induction induction|amod|END_ENTITY	Growth inhibition of human colon_cancer cells by nitric_oxide -LRB- NO -RRB- - donating aspirin is associated with cyclooxygenase-2 induction and beta-catenin/T-cell factor signaling , nuclear factor-kappaB , and NO synthase 2 inhibition : implications for chemoprevention .
14646256	0	nitric_oxide	112,124	cyclooxygenase-2	81,97	nitric oxide	cyclooxygenase-2	MESH:D009569	19225(Tax:10090)	Chemical	Gene	synthase|amod|START_ENTITY synthase|amod|END_ENTITY	Harpagophytum procumbens suppresses lipopolysaccharide-stimulated expressions of cyclooxygenase-2 and inducible nitric_oxide synthase in fibroblast cell line L929 .
14977638	0	nitric_oxide	10,22	cyclooxygenase-2	44,60	nitric oxide	cyclooxygenase-2	MESH:D009569	19225(Tax:10090)	Chemical	Gene	START_ENTITY|xcomp|promoting promoting|dep|END_ENTITY	Inducible nitric_oxide synthase upregulates cyclooxygenase-2 in mouse cholangiocytes promoting cell growth .
15155540	0	nitric_oxide	97,109	cyclooxygenase-2	110,126	nitric oxide	cyclooxygenase-2	MESH:D009569	19225(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|expression expression|amod|END_ENTITY	Carrageenan-induced mouse paw oedema is biphasic , age-weight dependent and displays differential nitric_oxide cyclooxygenase-2 expression .
15879708	0	nitric_oxide	78,90	cyclooxygenase-2	47,63	nitric oxide	cyclooxygenase-2	MESH:D009569	282023(Tax:9913)	Chemical	Gene	acidic|nmod|START_ENTITY acidic|dobj|expression expression|amod|END_ENTITY	Attenuation of extracellular acidic pH-induced cyclooxygenase-2 expression by nitric_oxide .
15919429	0	nitric_oxide	100,112	cyclooxygenase-2	73,89	nitric oxide	cyclooxygenase-2	MESH:D009569	29527(Tax:10116)	Chemical	Gene	synthase|compound|START_ENTITY synthase|amod|END_ENTITY	Blockade of fibronectin-alpha4beta1 adhesive interactions down-regulates cyclooxygenase-2 inducible nitric_oxide synthase and prolongs recipient survival in a 24-hour model of cold hepatic_ischemia-reperfusion injury .
16339820	0	nitric_oxide	74,86	cyclooxygenase-2	130,146	nitric oxide	cyclooxygenase-2	MESH:D009569	5743	Chemical	Gene	synthase|amod|START_ENTITY synthase|nmod|END_ENTITY	Atorvastatin-induced cardioprotection is mediated by increasing inducible nitric_oxide synthase and consequent S-nitrosylation of cyclooxygenase-2 .
16600210	0	nitric_oxide	66,78	cyclooxygenase-2	122,138	nitric oxide	cyclooxygenase-2	MESH:D009569	29527(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY effects|nmod|inhibition synthase|nsubj|effects synthase|nmod|expression expression|nmod|END_ENTITY	Differential effects of selective and non-selective inhibition of nitric_oxide synthase on the expression and activity of cyclooxygenase-2 during gastric ulcer_healing .
16645140	0	nitric_oxide	125,137	cyclooxygenase-2	24,40	nitric oxide	cyclooxygenase-2	MESH:D009569	19225(Tax:10090)	Chemical	Gene	mice|amod|START_ENTITY enhanced|nmod|mice enhanced|nsubj|expression expression|nmod|mediates mediates|amod|END_ENTITY	Increased expression of cyclooxygenase-2 mediates enhanced contraction to endothelin ETA receptor stimulation in endothelial nitric_oxide synthase knockout mice .
16835502	0	nitric_oxide	182,194	cyclooxygenase-2	151,167	nitric oxide	cyclooxygenase-2	MESH:D009569	29527(Tax:10116)	Chemical	Gene	pathways|amod|START_ENTITY pathways|amod|END_ENTITY	Chemopreventive potential of diallylsulfide , lycopene and theaflavin during chemically induced colon_carcinogenesis in rat colon through modulation of cyclooxygenase-2 and inducible nitric_oxide synthase pathways .
16879691	0	nitric_oxide	98,110	cyclooxygenase-2	40,56	nitric oxide	cyclooxygenase-2	MESH:D009569	29527(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY inhibitor|nmod|expression inhibitor|amod|END_ENTITY	Effects of intravesical instillation of cyclooxygenase-2 inhibitor on the expression of inducible nitric_oxide synthase and nerve_growth_factor in cyclophosphamide-induced overactive_bladder .
16920373	0	nitric_oxide	60,72	cyclooxygenase-2	97,113	nitric oxide	cyclooxygenase-2	MESH:D009569	29527(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Ameliorative effect of combined administration of inducible nitric_oxide synthase inhibitor with cyclooxygenase-2 inhibitors in neuropathic_pain in rats .
17016494	0	nitric_oxide	11,23	cyclooxygenase-2	60,76	nitric oxide	cyclooxygenase-2	MESH:D009569	29527(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY Effects|nmod|synthase inhibition|nsubj|Effects inhibition|nmod|inhibition inhibition|amod|END_ENTITY	Effects of nitric_oxide synthase inhibition with or without cyclooxygenase-2 inhibition on resting haemodynamics and responses to exendin-4 .
17141756	0	nitric_oxide	47,59	cyclooxygenase-2	16,32	nitric oxide	cyclooxygenase-2	MESH:D009569	19225(Tax:10090)	Chemical	Gene	synthase|amod|START_ENTITY synthase|amod|END_ENTITY	Isatins inhibit cyclooxygenase-2 and inducible nitric_oxide synthase in a mouse macrophage cell line .
17277882	0	nitric_oxide	51,63	cyclooxygenase-2	20,36	nitric oxide	cyclooxygenase-2	MESH:D009569	5743	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Triptolide inhibits cyclooxygenase-2 and inducible nitric_oxide synthase expression in human colon_cancer and leukemia cells .
17785622	0	nitric_oxide	39,51	cyclooxygenase-2	89,105	nitric oxide	cyclooxygenase-2	MESH:D009569	19225(Tax:10090)	Chemical	Gene	therapy|amod|START_ENTITY afforded|nmod|therapy Cardioprotection|acl|afforded mediated|nsubjpass|Cardioprotection mediated|nmod|END_ENTITY	Cardioprotection afforded by inducible nitric_oxide synthase gene therapy is mediated by cyclooxygenase-2 via a nuclear factor-kappaB dependent pathway .
17994684	0	nitric_oxide	120,132	cyclooxygenase-2	92,108	nitric oxide	cyclooxygenase-2	MESH:D009569	29527(Tax:10116)	Chemical	Gene	donors|compound|START_ENTITY donors|amod|END_ENTITY	Structure-based design , synthesis , and biological evaluation of indomethacin derivatives as cyclooxygenase-2 inhibiting nitric_oxide donors .
18042295	0	nitric_oxide	126,138	cyclooxygenase-2	17,33	nitric oxide	cyclooxygenase-2	MESH:D009569	5743	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|expression expression|amod|END_ENTITY	The effects of a cyclooxygenase-2 -LRB- COX-2 -RRB- expression and inhibition on human uveal_melanoma cell proliferation and macrophage nitric_oxide production .
18435907	0	nitric_oxide	182,194	cyclooxygenase-2	151,167	nitric oxide	cyclooxygenase-2	MESH:D009569	5743	Chemical	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Tranilast , an orally active anti-allergic drug , up-regulates the anti-inflammatory heme_oxygenase-1 expression but down-regulates the pro-inflammatory cyclooxygenase-2 and inducible nitric_oxide synthase expression in RAW264 .7 macrophages .
18571461	0	nitric_oxide	142,154	cyclooxygenase-2	111,127	nitric oxide	cyclooxygenase-2	MESH:D009569	19225(Tax:10090)	Chemical	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Caffeic_acid_phenethyl_ester protects mice from lethal endotoxin shock and inhibits lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric_oxide synthase expression in RAW 264.7 macrophages via the p38/ERK and NF-kappaB pathways .
18598759	0	nitric_oxide	10,22	cyclooxygenase-2	33,49	nitric oxide	cyclooxygenase-2	MESH:D009569	19225(Tax:10090)	Chemical	Gene	regulates|advmod|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Exogenous nitric_oxide regulates cyclooxygenase-2 expression and prostaglandin_D -LRB- 2 -RRB- generation through p38_MAPK in mouse bone marrow-derived mast cells .
19111593	0	nitric_oxide	99,111	cyclooxygenase-2	68,84	nitric oxide	cyclooxygenase-2	MESH:D009569	5743	Chemical	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Ecklonia cava ethanolic extracts inhibit lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric_oxide synthase expression in BV2 microglia via the MAP kinase and NF-kappaB pathways .
20543082	0	nitric_oxide	10,22	cyclooxygenase-2	72,88	nitric oxide	cyclooxygenase-2	MESH:D009569	29527(Tax:10116)	Chemical	Gene	START_ENTITY|ccomp|exaggerates exaggerates|dobj|induction induction|amod|END_ENTITY	Inducible nitric_oxide synthase gene deletion exaggerates MAPK-mediated cyclooxygenase-2 induction by inflammatory stimuli .
21710354	0	nitric_oxide	45,57	cyclooxygenase-2	14,30	nitric oxide	cyclooxygenase-2	MESH:D009569	5743	Chemical	Gene	synthase|amod|START_ENTITY synthase|amod|END_ENTITY	Inhibition of cyclooxygenase-2 and inducible nitric_oxide synthase by silymarin in proliferating mesenchymal stem cells : comparison with glutathione modifiers .
21990143	0	nitric_oxide	33,45	cyclooxygenase-2	83,99	nitric oxide	cyclooxygenase-2	MESH:D009569	5743	Chemical	Gene	acid|amod|START_ENTITY acid|dep|pharmacophore pharmacophore|amod|END_ENTITY	Rofecoxib analogues possessing a nitric_oxide donor sulfohydroxamic acid -LRB- SO2NHOH -RRB- cyclooxygenase-2 pharmacophore : synthesis , molecular modeling , and biological evaluation as anti-inflammatory agents .
22545970	0	nitric_oxide	43,55	cyclooxygenase-2	94,110	nitric oxide	cyclooxygenase-2	MESH:D009569	29527(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|effect effect|nmod|inhibitor inhibitor|amod|END_ENTITY	Contribution of vasoactive eicosanoids and nitric_oxide production to the effect of selective cyclooxygenase-2 inhibitor , NS-398 , on endotoxin-induced hypotension in rats .
22993079	0	nitric_oxide	57,69	cyclooxygenase-2	80,96	nitric oxide	cyclooxygenase-2	MESH:D009569	5743	Chemical	Gene	kinases|amod|START_ENTITY kinases|amod|END_ENTITY	Phlorofucofuroeckol_A suppresses expression of inducible nitric_oxide synthase , cyclooxygenase-2 , and pro-inflammatory cytokines via inhibition of nuclear factor-kB , c-Jun NH2-terminal kinases , and Akt in microglial cells .
23534442	0	nitric_oxide	134,146	cyclooxygenase-2	106,122	nitric oxide	cyclooxygenase-2	MESH:D009569	5743	Chemical	Gene	donors|compound|START_ENTITY donors|amod|END_ENTITY	Novel analgesic/anti-inflammatory agents : 1,5-diarylpyrrole nitrooxyalkyl_ethers and related compounds as cyclooxygenase-2 inhibiting nitric_oxide donors .
25196213	0	nitric_oxide	65,77	cyclooxygenase-2	34,50	nitric oxide	cyclooxygenase-2	MESH:D009569	19225(Tax:10090)	Chemical	Gene	synthase|amod|START_ENTITY synthase|amod|END_ENTITY	CDr10b inhibits the expression of cyclooxygenase-2 and inducible nitric_oxide synthase induced by lipopolysaccharide .
25881609	0	nitric_oxide	48,60	cyclooxygenase-2	20,36	nitric oxide	cyclooxygenase-2	MESH:D009569	5743	Chemical	Gene	vascular_endothelial_growth_factor|compound|START_ENTITY vascular_endothelial_growth_factor|amod|END_ENTITY	Tongxinluo inhibits cyclooxygenase-2 , inducible nitric_oxide synthase , hypoxia-inducible_factor-2a / vascular_endothelial_growth_factor to antagonize injury in hypoxia-stimulated cardiac microvascular endothelial cells .
8816815	0	nitric_oxide	171,183	cyclooxygenase-2	100,116	nitric oxide	cyclooxygenase-2	MESH:D009569	5743	Chemical	Gene	synthase|amod|START_ENTITY Identification|amod|synthase Identification|amod|dismutase dismutase|amod|END_ENTITY	Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli : cyclooxygenase-2 , manganese_superoxide dismutase , and endothelial cell nitric_oxide synthase are selectively up-regulated by steady laminar_shear_stress .
8982731	0	nitric_oxide	211,223	cyclooxygenase-2	148,164	nitric oxide	cyclooxygenase-2	MESH:D009569	19225(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY expression|nmod|synthase expression|amod|END_ENTITY	Induction of cyclooxygenase and nitric_oxide synthase in endotoxin-activated J774 macrophages is differentially regulated by indomethacin : enhanced cyclooxygenase-2 protein expression but reduction of inducible nitric_oxide synthase .
9858439	0	nitric_oxide	71,83	cyclooxygenase-2	131,147	nitric oxide	cyclooxygenase-2	MESH:D009569	5743	Chemical	Gene	level|compound|START_ENTITY level|acl|stimulating stimulating|dobj|synthesis synthesis|amod|END_ENTITY	Diacerhein and rhein reduce the interleukin_1beta stimulated inducible nitric_oxide synthesis level and activity while stimulating cyclooxygenase-2 synthesis in human osteoarthritic chondrocytes .
11437722	0	nitric_oxide	49,61	cyclooxygenase_2	18,34	nitric oxide	cyclooxygenase 2	MESH:D009569	5743	Chemical	Gene	synthase|compound|START_ENTITY synthase|amod|END_ENTITY	The expression of cyclooxygenase_2 and inducible nitric_oxide synthase indicates no active inflammation in vulvar_vestibulitis .
15297372	0	nitric_oxide	127,139	cyclooxygenase_2	99,115	nitric oxide	cyclooxygenase 2	MESH:D009569	5743	Chemical	Gene	synthase|compound|START_ENTITY synthase|amod|END_ENTITY	Effects of a combination of docosahexaenoic_acid and 1,4-phenylene _ bis -LRB- methylene -RRB- _ selenocyanate on cyclooxygenase_2 , inducible nitric_oxide synthase and beta-catenin pathways in colon_cancer cells .
20862685	0	nitric_oxide	99,111	cyclooxygenase_2	68,84	nitric oxide	cyclooxygenase 2	MESH:D009569	5743	Chemical	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Contribution of H3K4 methylation by SET-1A to interleukin-1-induced cyclooxygenase_2 and inducible nitric_oxide synthase expression in human osteoarthritis chondrocytes .
7545550	0	nitric_oxide	38,50	cyclosporin_A	11,24	nitric oxide	cyclosporin A	MESH:D009569	1161	Chemical	Gene	synthesis|compound|START_ENTITY Effects|nmod|synthesis Effects|nmod|END_ENTITY	Effects of cyclosporin_A and FK506 on nitric_oxide and tetrahydrobiopterin synthesis in bacterial lipopolysaccharide-treated J774 macrophages .
17125462	0	nitric_oxide	50,62	cytochrome_C	14,26	nitric oxide	cytochrome C	MESH:D009569	54205	Chemical	Gene	irradiation|compound|START_ENTITY Regulation|nmod|irradiation Regulation|nmod|activity activity|amod|END_ENTITY	Regulation of cytochrome_C peroxidase activity by nitric_oxide and laser irradiation .
8622628	0	nitric_oxide	8,20	cytochrome_P-450	60,76	nitric oxide	cytochrome P-450	MESH:D009569	25251(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|regulation regulation|nmod|END_ENTITY	Role of nitric_oxide in the cytokine-mediated regulation of cytochrome_P-450 .
9714302	0	nitric_oxide	8,20	cytochrome_P450	42,57	nitric oxide	cytochrome P450	MESH:D009569	13079(Tax:10090)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of nitric_oxide in the inhibition of cytochrome_P450 in the liver of mice infected with Chlamydia_trachomatis .
17588258	0	nitric_oxide	8,20	cytochrome_P450_1a1	42,61	nitric oxide	cytochrome P450 1a1	MESH:D009569	13076(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|downregulation downregulation|nmod|END_ENTITY	Role of nitric_oxide in downregulation of cytochrome_P450_1a1 and NADPH : _ Quinone_oxidoreductase_1 by tumor necrosis factor-alpha and lipopolysaccharide .
10597241	0	nitric_oxide	123,135	cytochrome_c	87,99	nitric oxide	cytochrome c	MESH:D009569	54205	Chemical	Gene	precedes|advcl|START_ENTITY precedes|dobj|release release|amod|END_ENTITY	p53 accumulation in apoptotic macrophages is an energy demanding process that precedes cytochrome_c release in response to nitric_oxide .
1375940	0	nitric_oxide	67,79	cytochrome_c	26,38	nitric oxide	cytochrome c	MESH:D009569	54205	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Ca2 + / calmodulin-dependent cytochrome_c reductase activity of brain nitric_oxide synthase .
15970472	0	nitric_oxide	27,39	cytochrome_c	85,97	nitric oxide	cytochrome c	MESH:D009569	54205	Chemical	Gene	biosensor|nmod|START_ENTITY based|nsubj|biosensor based|nmod|process process|nmod|nanotube nanotube|amod|END_ENTITY	A reagentless biosensor of nitric_oxide based on direct electron transfer process of cytochrome_c on multi-walled carbon nanotube .
16439016	0	nitric_oxide	8,20	cytochrome_c	38,50	nitric oxide	cytochrome c	MESH:D009569	54205	Chemical	Gene	prodrug|amod|START_ENTITY JS-K|appos|prodrug induces|nsubj|JS-K induces|dobj|release release|amod|END_ENTITY	JS-K , a nitric_oxide prodrug , induces cytochrome_c release and caspase activation in HL-60 myeloid_leukemia cells .
16598858	0	nitric_oxide	39,51	cytochrome_c	14,26	nitric oxide	cytochrome c	MESH:D009569	54205	Chemical	Gene	reacts|nmod|START_ENTITY reacts|nsubj|END_ENTITY	Mitochondrial cytochrome_c reacts with nitric_oxide via S-nitrosation .
18237625	0	nitric_oxide	12,24	cytochrome_c	57,69	nitric oxide	cytochrome c	MESH:D009569	54205	Chemical	Gene	Delivery|nmod|START_ENTITY Delivery|nmod|function function|nmod|END_ENTITY	Delivery of nitric_oxide for analysis of the function of cytochrome_c ' .
23618787	0	nitric_oxide	53,65	cytochrome_c	30,42	nitric oxide	cytochrome c	MESH:D009569	54205	Chemical	Gene	reductase|amod|START_ENTITY reductase|amod|END_ENTITY	Why is the reduction of NO in cytochrome_c dependent nitric_oxide reductase -LRB- cNOR -RRB- not electrogenic ?
24078591	0	nitric_oxide	30,42	cytochrome_c	48,60	nitric oxide	cytochrome c	MESH:D009569	54205	Chemical	Gene	pockets|nmod|START_ENTITY pockets|nmod|END_ENTITY	Gates and binding pockets for nitric_oxide with cytochrome_c ' , according to molecular dynamics .
2852951	0	nitric_oxide	21,33	cytochrome_c	44,56	nitric oxide	cytochrome c	MESH:D009569	54205	Chemical	Gene	structure|nmod|START_ENTITY inhibited|nsubj|structure inhibited|dobj|peroxidase peroxidase|amod|END_ENTITY	Crystal structure of nitric_oxide inhibited cytochrome_c peroxidase .
15546991	0	nitric_oxide	65,77	cytochrome_oxidase	32,50	nitric oxide	cytochrome oxidase	MESH:D009569	1351	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	On the mechanism and biology of cytochrome_oxidase inhibition by nitric_oxide .
22577939	0	nitric_oxide	83,95	cytoglobin	36,46	nitric oxide	cytoglobin	MESH:D009569	114757	Chemical	Gene	concentration|amod|START_ENTITY regulator|nmod|concentration Characterization|nmod|regulator Characterization|nmod|function function|nmod|END_ENTITY	Characterization of the function of cytoglobin as an oxygen-dependent regulator of nitric_oxide concentration .
23710929	0	nitric_oxide	32,44	cytoglobin	59,69	nitric oxide	cytoglobin	MESH:D009569	114757	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|nmod|END_ENTITY	Differences in oxygen-dependent nitric_oxide metabolism by cytoglobin and myoglobin account for their differing functional roles .
17713604	0	nitric_oxide	88,100	cytosolic_phospholipase_A2	22,48	nitric oxide	cytosolic phospholipase A2	MESH:D009569	24653(Tax:10116)	Chemical	Gene	level|nmod|START_ENTITY level|amod|END_ENTITY	Amyloid beta enhances cytosolic_phospholipase_A2 level and arachidonic_acid release via nitric_oxide in APP-transfected PC12 cells .
10337059	0	nitric_oxide	47,59	e-NOS	70,75	nitric oxide	e-NOS	MESH:D009569	24600(Tax:10116)	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Immunocytochemical localization of endothelial nitric_oxide synthase -LRB- e-NOS -RRB- and inducible nitric_oxide synthase -LRB- i-NOS -RRB- in rat neurohypophysis after transient cerebral_ischemia .
9562976	0	nitric_oxide	35,47	eIF-2_alpha	143,154	nitric oxide	eIF-2 alpha	MESH:D009569	229317(Tax:10090)	Chemical	Gene	correlates|amod|START_ENTITY synthesis|nmod|correlates synthesis|parataxis|induces induces|xcomp|END_ENTITY	Inhibition of protein synthesis by nitric_oxide correlates with cytostatic activity : nitric_oxide induces phosphorylation of initiation factor eIF-2_alpha .
9562976	0	nitric_oxide	85,97	eIF-2_alpha	143,154	nitric oxide	eIF-2 alpha	MESH:D009569	229317(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Inhibition of protein synthesis by nitric_oxide correlates with cytostatic activity : nitric_oxide induces phosphorylation of initiation factor eIF-2_alpha .
10383047	0	nitric_oxide	12,24	eNOS	37,41	nitric oxide	eNOS	MESH:D009569	24600(Tax:10116)	Chemical	Gene	synthetase|compound|START_ENTITY synthetase|appos|END_ENTITY	Endothelial nitric_oxide synthetase -LRB- eNOS -RRB- in astrocytes : another source of nitric_oxide in neocortex .
10383047	0	nitric_oxide	76,88	eNOS	37,41	nitric oxide	eNOS	MESH:D009569	24600(Tax:10116)	Chemical	Gene	source|nmod|START_ENTITY synthetase|dep|source synthetase|appos|END_ENTITY	Endothelial nitric_oxide synthetase -LRB- eNOS -RRB- in astrocytes : another source of nitric_oxide in neocortex .
10451235	0	nitric_oxide	27,39	eNOS	50,54	nitric oxide	eNOS	MESH:D009569	4846	Chemical	Gene	synthase|amod|START_ENTITY gene|amod|synthase gene|appos|END_ENTITY	A missense mutation of the nitric_oxide synthase -LRB- eNOS -RRB- gene -LRB- Glu298Asp -RRB- in five patients with coronary_artery_disease -- case reports .
11302556	0	nitric_oxide	69,81	eNOS	92,96	nitric oxide	eNOS	MESH:D009569	18127(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY gene|nmod|synthase lacking|dobj|gene mice|acl|lacking mice|dep|END_ENTITY	Circadian organization in male mice lacking the gene for endothelial nitric_oxide synthase -LRB- eNOS - / - -RRB- .
11337908	0	nitric_oxide	12,24	eNOS	35,39	nitric oxide	eNOS	MESH:D009569	24600(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|expression expression|appos|END_ENTITY	Endothelial nitric_oxide synthase -LRB- eNOS -RRB- expression and localization in healthy and diabetic rat hearts .
11692081	1	nitric_oxide	132,144	eNOS	155,159	nitric oxide	eNOS	MESH:D009569	4846	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms in the endothelial nitric_oxide synthase -LRB- eNOS -RRB- gene have been associated inconsistently with cardiovascular_diseases .
12904594	0	nitric_oxide	40,52	eNOS	63,67	nitric oxide	eNOS	MESH:D009569	24600(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY synthase|nsubj|expression synthase|dobj|END_ENTITY	Developmental expression of endothelial nitric_oxide synthase -LRB- eNOS -RRB- in the rat liver .
15032695	0	nitric_oxide	102,114	eNOS	125,129	nitric oxide	eNOS	MESH:D009569	4846	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	The relationship between inflammation and the anticoagulant pathway : the emerging role of endothelial nitric_oxide synthase -LRB- eNOS -RRB- .
15075219	0	nitric_oxide	20,32	eNOS	83,87	nitric oxide	eNOS	MESH:D009569	18127(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY Role|nmod|synthase Role|dep|insights insights|nmod|cells cells|amod|END_ENTITY	Role of endothelial nitric_oxide synthase in endothelial activation : insights from eNOS knockout endothelial cells .
15385574	1	nitric_oxide	200,212	eNOS	223,227	nitric oxide	eNOS	MESH:D009569	24600(Tax:10116)	Chemical	Gene	phosphorylation/dephosphorylation|nmod|START_ENTITY synthase|nsubj|phosphorylation/dephosphorylation synthase|ccomp|determinants determinants|nsubj|END_ENTITY	Localization and coordinate phosphorylation/dephosphorylation of endothelial nitric_oxide synthase -LRB- eNOS -RRB- are critical determinants for the basal and stimulated production of nitric_oxide .
15385574	1	nitric_oxide	298,310	eNOS	223,227	nitric oxide	eNOS	MESH:D009569	24600(Tax:10116)	Chemical	Gene	production|nmod|START_ENTITY determinants|nmod|production determinants|nsubj|END_ENTITY	Localization and coordinate phosphorylation/dephosphorylation of endothelial nitric_oxide synthase -LRB- eNOS -RRB- are critical determinants for the basal and stimulated production of nitric_oxide .
15905462	3	nitric_oxide	342,354	eNOS	365,369	nitric oxide	eNOS	MESH:D009569	4846	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	We have reported that laminar shear stress causes a brief increase in endothelial nitric_oxide synthase -LRB- eNOS -RRB- transcription , followed by a prolonged increase in eNOS mRNA stability .
16154438	1	nitric_oxide	248,260	eNOS	199,203	nitric oxide	eNOS	MESH:D009569	4846	Chemical	Gene	production|amod|START_ENTITY resulting|nmod|production resulting|nsubj|endothelial_nitric_oxide_synthase endothelial_nitric_oxide_synthase|appos|END_ENTITY	It has been demonstrated that the enzyme endothelial_nitric_oxide_synthase -LRB- eNOS -RRB- is present in adipose tissue , resulting in nitric_oxide production and subsequent inhibition of lipolysis .
16229016	0	nitric_oxide	86,98	eNOS	109,113	nitric oxide	eNOS	MESH:D009569	4846	Chemical	Gene	activity|amod|START_ENTITY activity|dep|END_ENTITY	Tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- regulates endothelial nitric_oxide synthase -LRB- eNOS -RRB- activity and its localization within the human vein endothelial cells -LRB- HUVEC -RRB- in culture .
17306574	0	nitric_oxide	43,55	eNOS	13,17	nitric oxide	eNOS	MESH:D009569	4846	Chemical	Gene	START_ENTITY|nsubj|Influence Influence|nmod|haplotypes haplotypes|amod|END_ENTITY	Influence of eNOS haplotypes on the plasma nitric_oxide products concentrations in hypertensive and type_2_diabetes_mellitus patients .
17558849	0	nitric_oxide	29,41	eNOS	52,56	nitric oxide	eNOS	MESH:D009569	4846	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Intron 4 VNTR of endothelial nitric_oxide synthase -LRB- eNOS -RRB- gene and diabetic_retinopathy in type 2 patients in southern India .
17971359	0	nitric_oxide	19,31	eNOS	42,46	nitric oxide	eNOS	MESH:D009569	4846	Chemical	Gene	Association|nmod|START_ENTITY synthase|nsubj|Association synthase|xcomp|polymorphism polymorphism|dep|END_ENTITY	Association of the nitric_oxide synthase -LRB- eNOS -RRB- gene polymorphism with increased risk for both lupus_glomerulonephritis and rheumatoid_arthritis in a single genetically homogeneous population .
18348063	0	nitric_oxide	32,44	eNOS	74,78	nitric oxide	eNOS	MESH:D009569	24600(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|expression expression|compound|END_ENTITY	The effect of puerarin on serum nitric_oxide concentration and myocardial eNOS expression in rats with myocardial_infarction .
18537098	0	nitric_oxide	12,24	eNOS	35,39	nitric oxide	eNOS	MESH:D009569	4846	Chemical	Gene	polymorphisms|amod|START_ENTITY polymorphisms|appos|END_ENTITY	Endothelial nitric_oxide synthase -LRB- eNOS -RRB- gene polymorphisms and their association with type 2 diabetes-related traits in Mexican Americans .
18539276	0	nitric_oxide	52,64	eNOS	75,79	nitric oxide	eNOS	MESH:D009569	4846	Chemical	Gene	START_ENTITY|dobj|gene gene|appos|END_ENTITY	The association of 4a4b polymorphism of endothelial nitric_oxide synthase -LRB- eNOS -RRB- gene with the sperm morphology in Korean infertile men .
18657492	0	nitric_oxide	12,24	eNOS	35,39	nitric oxide	eNOS	MESH:D009569	4846	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Endothelial nitric_oxide synthase -LRB- eNOS -RRB- is not upregulated in gastric mucosa of Helicobacter_pylori -LRB- H. _ pylori -RRB- - positive patients with type 2 diabetes_mellitus .
18682401	0	nitric_oxide	96,108	eNOS	75,79	nitric oxide	eNOS	MESH:D009569	4846	Chemical	Gene	generation|amod|START_ENTITY role|nmod|generation role|nmod|complexes complexes|nmod|END_ENTITY	Functional role of HSP90 complexes with endothelial_nitric-oxide_synthase -LRB- eNOS -RRB- and calpain on nitric_oxide generation in endothelial cells .
18715945	0	nitric_oxide	99,111	eNOS	187,191	nitric oxide	eNOS	MESH:D009569	24600(Tax:10116)	Chemical	Gene	interaction|amod|START_ENTITY interaction|nmod|antagonism antagonism|nmod|action action|nmod|END_ENTITY	Mitochondrial respiratory enzyme complexes in rostral ventrolateral medulla as cellular targets of nitric_oxide and superoxide interaction in the antagonism of antihypertensive action of eNOS transgene .
18926858	0	nitric_oxide	83,95	eNOS	53,57	nitric oxide	eNOS	MESH:D009569	4846	Chemical	Gene	muscle|nmod|START_ENTITY Autoinhibition|nmod|muscle Autoinhibition|appos|END_ENTITY	Autoinhibition of endothelial_nitric_oxide_synthase -LRB- eNOS -RRB- in gut smooth muscle by nitric_oxide .
19287060	0	nitric_oxide	12,24	eNOS	35,39	nitric oxide	eNOS	MESH:D009569	4846	Chemical	Gene	Glu298|amod|START_ENTITY Glu298|appos|END_ENTITY	Endothelial nitric_oxide synthase -LRB- eNOS -RRB- Glu298 -- > Asp polymorphism -LRB- G894T -RRB- among south Indians .
19490210	0	nitric_oxide	41,53	eNOS	63,67	nitric oxide	eNOS	MESH:D009569	4846	Chemical	Gene	synthase|compound|START_ENTITY polymorphism|nmod|synthase END_ENTITY|nsubj|polymorphism	Intron 4 polymorphism of the endothelial nitric_oxide synthase eNOS gene and early microangiopathy in type_1_diabetes .
19608646	0	nitric_oxide	92,104	eNOS	31,35	nitric oxide	eNOS	MESH:D009569	4846	Chemical	Gene	production|compound|START_ENTITY modulates|dobj|production modulates|nsubj|trafficking/interaction trafficking/interaction|nmod|END_ENTITY	The trafficking/interaction of eNOS and caveolin-1 induced by insulin modulates endothelial nitric_oxide production .
20005399	0	nitric_oxide	12,24	eNOS	35,39	nitric oxide	eNOS	MESH:D009569	4846	Chemical	Gene	synthase|nsubj|START_ENTITY synthase|xcomp|polymorphism polymorphism|dep|END_ENTITY	Endothelial nitric_oxide synthase -LRB- eNOS -RRB- gene polymorphism in early term chronic_allograft_nephropathy .
20233295	0	nitric_oxide	45,57	eNOS	68,72	nitric oxide	eNOS	MESH:D009569	24600(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY synthase|nsubj|regulation synthase|dobj|END_ENTITY	Post-translational regulation of endothelial nitric_oxide synthase -LRB- eNOS -RRB- by estrogens in the rat vagina .
20428939	0	nitric_oxide	12,24	eNOS	35,39	nitric oxide	eNOS	MESH:D009569	4846	Chemical	Gene	synthase|compound|START_ENTITY associated|nsubjpass|synthase associated|dep|END_ENTITY	Endothelial nitric_oxide synthase -LRB- eNOS -RRB- 894_G > T polymorphism is associated with breast_cancer risk : a meta-analysis .
20457799	0	nitric_oxide	33,45	eNOS	11,15	nitric oxide	eNOS	MESH:D009569	4846	Chemical	Gene	formation|amod|START_ENTITY polymorphisms|nmod|formation polymorphisms|nsubj|Effects Effects|nmod|END_ENTITY	Effects of eNOS polymorphisms on nitric_oxide formation in healthy pregnancy and in pre-eclampsia .
21063103	0	nitric_oxide	64,76	eNOS	40,44	nitric oxide	eNOS	MESH:D009569	4846	Chemical	Gene	anion|amod|START_ENTITY produce|dobj|anion END_ENTITY|advcl|produce	Opposite effect of Hsp90a and Hsp90b on eNOS ability to produce nitric_oxide or superoxide anion in human embryonic kidney cells .
21383590	2	nitric_oxide	422,434	eNOS	445,449	nitric oxide	eNOS	MESH:D009569	4846	Chemical	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	The purpose of this study was to determine whether chronic exposure to nicotine alters angiogenic activity in human umbilical vein endothelial cells and to identify a potential role for endothelial nitric_oxide synthase -LRB- eNOS -RRB- expression .
21555345	0	nitric_oxide	103,115	eNOS	0,4	nitric oxide	eNOS	MESH:D009569	4846	Chemical	Gene	output|amod|START_ENTITY alters|dobj|output alters|nsubj|activation activation|amod|END_ENTITY	eNOS activation and NO function : pregnancy adaptive programming of capacitative entry responses alters nitric_oxide -LRB- NO -RRB- output in vascular endothelium -- new insights into eNOS regulation through adaptive cell signaling .
21555345	0	nitric_oxide	103,115	eNOS	171,175	nitric oxide	eNOS	MESH:D009569	4846	Chemical	Gene	output|amod|START_ENTITY output|dep|insights insights|nmod|regulation regulation|amod|END_ENTITY	eNOS activation and NO function : pregnancy adaptive programming of capacitative entry responses alters nitric_oxide -LRB- NO -RRB- output in vascular endothelium -- new insights into eNOS regulation through adaptive cell signaling .
21623032	0	nitric_oxide	26,38	eNOS	49,53	nitric oxide	eNOS	MESH:D009569	4846	Chemical	Gene	Prevalence|nmod|START_ENTITY synthase|nsubj|Prevalence synthase|xcomp|gene gene|dep|END_ENTITY	Prevalence of endothelial nitric_oxide synthase -LRB- eNOS -RRB- gene exon 7 Glu298Asp variant in North Eastern India .
21642378	0	nitric_oxide	112,124	eNOS	0,4	nitric oxide	eNOS	MESH:D009569	4846	Chemical	Gene	activity|compound|START_ENTITY control|nmod|activity responsible|nmod|control motifs|amod|responsible activation|dep|motifs activation|amod|END_ENTITY	eNOS activation and NO function : structural motifs responsible for the posttranslational control of endothelial nitric_oxide synthase activity .
21899406	0	nitric_oxide	82,94	eNOS	32,36	nitric oxide	eNOS	MESH:D009569	4846	Chemical	Gene	levels|amod|START_ENTITY Determination|nmod|levels Determination|nmod|effects effects|nmod|polymorphisms polymorphisms|amod|END_ENTITY	Determination of the effects of eNOS gene polymorphisms -LRB- T-786C and Glu298Asp -RRB- on nitric_oxide levels in a methylmercury-exposed population .
22283728	0	nitric_oxide	56,68	eNOS	90,94	nitric oxide	eNOS	MESH:D009569	4846	Chemical	Gene	release|compound|START_ENTITY blockers|nmod|release Effects|nmod|blockers Effects|dep|role role|nmod|variants variants|amod|END_ENTITY	Effects of angiotensin receptor blockers on endothelial nitric_oxide release : the role of eNOS variants .
22865486	2	nitric_oxide	216,228	eNOS	414,418	nitric oxide	VEGF	MESH:D009569	7422	Chemical	Gene	involvement|nmod|START_ENTITY evidence|nmod|involvement is|nsubj|evidence approaches|advcl|is studied|dep|approaches studied|nsubjpass|synthase synthase|appos|END_ENTITY	Because there is evidence for the involvement of nitric_oxide -LRB- NO -RRB- in migraine pathophysiology , candidate gene approaches focusing on genes affecting the endothelial function have been studied including the genes encoding endothelial NO synthase -LRB- eNOS -RRB- , inducible_NO_synthase -LRB- iNOS -RRB- , and vascular_endothelial_growth_factor -LRB- VEGF -RRB- .
23319464	0	nitric_oxide	65,77	eNOS	0,4	nitric oxide	eNOS	MESH:D009569	4846	Chemical	Gene	production|amod|START_ENTITY yields|dobj|production yields|nsubj|transfection transfection|amod|END_ENTITY	eNOS transfection of adipose-derived stem cells yields bioactive nitric_oxide production and improved results in vascular tissue engineering .
23400313	0	nitric_oxide	48,60	eNOS	71,75	nitric oxide	eNOS	MESH:D009569	4846	Chemical	Gene	diversity|nmod|START_ENTITY synthase|nsubj|diversity synthase|ccomp|polymorphisms polymorphisms|nsubj|END_ENTITY	Extensive ethnogenomic diversity of endothelial nitric_oxide synthase -LRB- eNOS -RRB- polymorphisms .
23710540	0	nitric_oxide	24,36	eNOS	47,51	nitric oxide	eNOS	MESH:D009569	4846	Chemical	Gene	Analysis|nmod|START_ENTITY synthase|nsubj|Analysis synthase|xcomp|polymorphism polymorphism|dep|END_ENTITY	Analysis of endothelial nitric_oxide synthase -LRB- eNOS -RRB- G894T polymorphism and semen parameters in a Chinese Han population .
24019403	0	nitric_oxide	82,94	eNOS	105,109	nitric oxide	eNOS	MESH:D009569	4846	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Target sequencing , cell experiments , and a population study establish endothelial nitric_oxide synthase -LRB- eNOS -RRB- gene as hypertension susceptibility gene .
24605593	0	nitric_oxide	47,59	eNOS	84,88	nitric oxide	eNOS	MESH:D009569	4846	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- T -LRB- -786 -RRB- -- > C-polymorphism of the endothelial nitric_oxide synthase promoter gene -LRB- eNOS -RRB- and exercise performance in sport -RSB- .
24810690	0	nitric_oxide	12,24	eNOS	35,39	nitric oxide	eNOS	MESH:D009569	4846	Chemical	Gene	synthase|compound|START_ENTITY synthase|dep|END_ENTITY	Endothelial nitric_oxide synthase -LRB- eNOS -RRB- 4b/a gene polymorphisms and coronary_artery_disease : evidence from a meta-analysis .
24952486	0	nitric_oxide	38,50	eNOS	90,94	nitric oxide	eNOS	MESH:D009569	4846	Chemical	Gene	production|amod|START_ENTITY suppresses|dobj|production suppresses|nmod|END_ENTITY	Oxidized extracellular DNA suppresses nitric_oxide production by endothelial_NO_synthase -LRB- eNOS -RRB- in human endothelial cells -LRB- HUVEC -RRB- .
25278292	0	nitric_oxide	71,83	eNOS	13,17	nitric oxide	eNOS	MESH:D009569	18127(Tax:10090)	Chemical	Gene	scavenging|amod|START_ENTITY required|nmod|scavenging required|nsubjpass|coupling coupling|amod|END_ENTITY	Hemoglobin_a / eNOS coupling at myoendothelial junctions is required for nitric_oxide scavenging during vasoconstriction .
25407137	0	nitric_oxide	52,64	eNOS	75,79	nitric oxide	eNOS	MESH:D009569	4846	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	Extract from Ribes nigrum leaves in vitro activates nitric_oxide synthase -LRB- eNOS -RRB- and increases CD39 expression in human endothelial cells .
25606389	0	nitric_oxide	12,24	eNOS	35,39	nitric oxide	eNOS	MESH:D009569	4846	Chemical	Gene	synthase|nsubj|START_ENTITY synthase|dobj|polymorphism polymorphism|appos|END_ENTITY	Endothelial nitric_oxide synthase -LRB- eNOS -RRB- 4b/a polymorphism and the risk of diabetic_nephropathy in type_2_diabetes_mellitus : A meta-analysis .
26535938	0	nitric_oxide	135,147	eNOS	163,167	nitric oxide	eNOS	MESH:D009569	4846	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A multilevel prediction of physiological response to challenge : Interactions among child maltreatment , neighborhood crime , endothelial nitric_oxide synthase gene -LRB- eNOS -RRB- , and GABA -LRB- A -RRB- _ receptor_subunit_alpha-6 gene -LRB- GABRA6 -RRB- .
10781649	0	nitric_oxide	49,61	ecNOS	72,77	nitric oxide	ecNOS	MESH:D009569	4846	Chemical	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Methylene_tetrahydrofolate reductase -LRB- MTHFR -RRB- and nitric_oxide synthase -LRB- ecNOS -RRB- genes and risks of peripheral_arterial_disease and coronary_heart_disease : Edinburgh Artery Study .
10947811	0	nitric_oxide	49,61	ecNOS	72,77	nitric oxide	ecNOS	MESH:D009569	24600(Tax:10116)	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Transient action of the endothelial constitutive nitric_oxide synthase -LRB- ecNOS -RRB- mediates the development of thermal hypersensitivity following peripheral_nerve_injury .
12605344	0	nitric_oxide	12,24	ecNOS	35,40	nitric oxide	ecNOS	MESH:D009569	4846	Chemical	Gene	synthase|nsubj|START_ENTITY synthase|xcomp|polymorphism polymorphism|dep|END_ENTITY	Endothelial nitric_oxide synthase -LRB- ecNOS -RRB- 4 a/b gene polymorphism and carotid artery intima-media_thickness in type-1 diabetic patients .
16377020	0	nitric_oxide	31,43	ecNOS	54,59	nitric oxide	ecNOS	MESH:D009569	4846	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of the endothelial nitric_oxide synthase -LRB- ecNOS -RRB- gene polymorphism with carotid_atherosclerosis in type 2 diabetes .
16923191	0	nitric_oxide	36,48	ecNOS	116,121	nitric oxide	ecNOS	MESH:D009569	4846	Chemical	Gene	polymorphism|amod|START_ENTITY association|nmod|polymorphism association|dep|effect effect|nmod|polymorphism polymorphism|amod|END_ENTITY	Negative association of endothelial nitric_oxide gene polymorphism with hypertension in Turkish patients : effect of ecNOS polymorphism on left_ventricular_hypertrophy .
19779764	0	nitric_oxide	53,65	ecNOS	76,81	nitric oxide	ecNOS	MESH:D009569	4846	Chemical	Gene	gene|compound|START_ENTITY gene|dep|END_ENTITY	Lack of association between endothelial constitutive nitric_oxide synthase -LRB- ecNOS 4 b/a -RRB- gene polymorphism and rheumatic_heart_disease .
21069449	0	nitric_oxide	13,25	ecNOS	78,83	nitric oxide	ecNOS	MESH:D009569	4846	Chemical	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Plasma total nitric_oxide and endothelial constitutive nitric_oxide synthase -LRB- ecNOS -RRB- gene polymorphism : a study in a South Indian population .
21069449	0	nitric_oxide	55,67	ecNOS	78,83	nitric oxide	ecNOS	MESH:D009569	4846	Chemical	Gene	polymorphism|compound|START_ENTITY polymorphism|appos|END_ENTITY	Plasma total nitric_oxide and endothelial constitutive nitric_oxide synthase -LRB- ecNOS -RRB- gene polymorphism : a study in a South Indian population .
9149402	1	nitric_oxide	236,248	ecNOS	259,264	nitric oxide	ecNOS	MESH:D009569	4846	Chemical	Gene	cDNA|compound|START_ENTITY cDNA|appos|END_ENTITY	The lack of sequence information and clones of porcine pulmonary artery endothelial cell -LRB- PAEC -RRB- constitutive nitric_oxide synthase -LRB- ecNOS -RRB- cDNA limits comparative analysis between porcine and human PAEC .
9588702	0	nitric_oxide	25,37	ecNOS	48,53	nitric oxide	ecNOS	MESH:D009569	4846	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Endothelial constitutive nitric_oxide synthase -LRB- ecNOS -RRB- localization in normal and neoplastic salivary tissue .
9631886	0	nitric_oxide	25,37	ecNOS	48,53	nitric oxide	ecNOS	MESH:D009569	4846	Chemical	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	Constitutive endothelial nitric_oxide synthase -LRB- ecNOS -RRB- gene expression in human monocytes .
9678446	0	nitric_oxide	33,45	ecNOS	56,61	nitric oxide	ecNOS	MESH:D009569	4846	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	High accumulation of endothelial nitric_oxide synthase -LRB- ecNOS -RRB- : a gene polymorphism in patients with end-stage_renal_disease .
9867209	0	nitric_oxide	41,53	ecNOS	64,69	nitric oxide	ecNOS	MESH:D009569	24600(Tax:10116)	Chemical	Gene	synthase|compound|START_ENTITY expression|nmod|synthase expression|dep|END_ENTITY	Increased expression of endothelial cell nitric_oxide synthase -LRB- ecNOS -RRB- in afferent and glomerular endothelial cells is involved in glomerular hyperfiltration of diabetic_nephropathy .
11978735	0	nitric_oxide	33,45	endostatin	101,111	nitric oxide	endostatin	MESH:D009569	80781	Chemical	Gene	synthase|compound|START_ENTITY Dephosphorylation|nmod|synthase contributes|nsubj|Dephosphorylation contributes|nmod|effects effects|nmod|END_ENTITY	Dephosphorylation of endothelial nitric_oxide synthase contributes to the anti-angiogenic effects of endostatin .
10946913	0	nitric_oxide	30,42	endothelial_nitric_oxide_synthase	101,134	nitric oxide	endothelial nitric oxide synthase	MESH:D009569	4846	Chemical	Gene	release|amod|START_ENTITY stimulates|dobj|release stimulates|nmod|cells cells|nmod|activation activation|nmod|END_ENTITY	Raloxifene acutely stimulates nitric_oxide release from human endothelial cells via an activation of endothelial_nitric_oxide_synthase .
10963734	0	nitric_oxide	95,107	endothelial_nitric_oxide_synthase	17,50	nitric oxide	endothelial nitric oxide synthase	MESH:D009569	4846	Chemical	Gene	availability|amod|START_ENTITY restores|dobj|availability restores|nsubj|transfer transfer|nmod|END_ENTITY	Gene transfer of endothelial_nitric_oxide_synthase but not Cu/Zn _ superoxide dismutase restores nitric_oxide availability in the SHRSP .
12642395	0	nitric_oxide	49,61	endothelial_nitric_oxide_synthase	109,142	nitric oxide	endothelial nitric oxide synthase	MESH:D009569	18127(Tax:10090)	Chemical	Gene	store|nmod|START_ENTITY store|dep|dependence dependence|nmod|expression expression|nmod|END_ENTITY	A photosensitive vascular smooth muscle store of nitric_oxide in mouse aorta : no dependence on expression of endothelial_nitric_oxide_synthase .
12686872	0	nitric_oxide	70,82	endothelial_nitric_oxide_synthase	17,50	nitric oxide	endothelial nitric oxide synthase	MESH:D009569	24600(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY restores|dobj|synthesis restores|nsubj|transfer transfer|nmod|END_ENTITY	Gene transfer of endothelial_nitric_oxide_synthase partially restores nitric_oxide synthesis and erectile function in streptozotocin diabetic rats .
14586499	0	nitric_oxide	31,43	endothelial_nitric_oxide_synthase	128,161	nitric oxide	endothelial nitric oxide synthase	MESH:D009569	24600(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY increases|dobj|production increases|advcl|enhancing enhancing|dobj|transcription transcription|nmod|END_ENTITY	Proinsulin C-peptide increases nitric_oxide production by enhancing mitogen-activated protein-kinase-dependent transcription of endothelial_nitric_oxide_synthase in aortic endothelial cells of Wistar_rats .
15233974	0	nitric_oxide	61,73	endothelial_nitric_oxide_synthase	12,45	nitric oxide	endothelial nitric oxide synthase	MESH:D009569	4846	Chemical	Gene	START_ENTITY|nsubj|Relation Relation|nmod|gene gene|amod|END_ENTITY	Relation of endothelial_nitric_oxide_synthase gene to plasma nitric_oxide level , endothelial function , and blood pressure in African Americans .
15607726	0	nitric_oxide	24,36	endothelial_nitric_oxide_synthase	99,132	nitric oxide	endothelial nitric oxide synthase	MESH:D009569	287024(Tax:9913)	Chemical	Gene	production|amod|START_ENTITY decreases|dobj|production decreases|parataxis|role role|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Retinoic_acid decreases nitric_oxide production in endothelial cells : a role of phosphorylation of endothelial_nitric_oxide_synthase at Ser -LRB- 1179 -RRB- .
15637297	0	nitric_oxide	158,170	endothelial_nitric_oxide_synthase	184,217	nitric oxide	endothelial nitric oxide synthase	MESH:D009569	18127(Tax:10090)	Chemical	Gene	START_ENTITY|acl|derived derived|nmod|END_ENTITY	A defect of neuronal nitric_oxide synthase increases xanthine_oxidase-derived superoxide anion and attenuates the control of myocardial oxygen consumption by nitric_oxide derived from endothelial_nitric_oxide_synthase .
15637297	0	nitric_oxide	21,33	endothelial_nitric_oxide_synthase	184,217	nitric oxide	endothelial nitric oxide synthase	MESH:D009569	18127(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY defect|nmod|synthase increases|nsubj|defect increases|nmod|nitric_oxide nitric_oxide|acl|derived derived|nmod|END_ENTITY	A defect of neuronal nitric_oxide synthase increases xanthine_oxidase-derived superoxide anion and attenuates the control of myocardial oxygen consumption by nitric_oxide derived from endothelial_nitric_oxide_synthase .
15941833	0	nitric_oxide	50,62	endothelial_nitric_oxide_synthase	120,153	nitric oxide	endothelial nitric oxide synthase	MESH:D009569	4846	Chemical	Gene	bioavailability|amod|START_ENTITY critical|nmod|bioavailability uncoupling|amod|critical uncoupling|nmod|END_ENTITY	Endothelial dihydrofolate_reductase : critical for nitric_oxide bioavailability and role in angiotensin_II uncoupling of endothelial_nitric_oxide_synthase .
16702986	0	nitric_oxide	88,100	endothelial_nitric_oxide_synthase	158,191	nitric oxide	endothelial nitric oxide synthase	MESH:D009569	18127(Tax:10090)	Chemical	Gene	not|nmod|START_ENTITY not|nmod|mice mice|nmod|overexpression overexpression|nmod|END_ENTITY	Cardioprotective effects of atrasentan , an endothelin-A_receptor antagonist , but not of nitric_oxide in diabetic mice with myocyte-specific overexpression of endothelial_nitric_oxide_synthase .
17697943	0	nitric_oxide	14,26	endothelial_nitric_oxide_synthase	40,73	nitric oxide	endothelial nitric oxide synthase	MESH:D009569	4846	Chemical	Gene	formation|amod|START_ENTITY Modulation|nmod|formation Modulation|nmod|haplotypes haplotypes|amod|END_ENTITY	Modulation of nitric_oxide formation by endothelial_nitric_oxide_synthase gene haplotypes .
17922342	0	nitric_oxide	128,140	endothelial_nitric_oxide_synthase	39,72	nitric oxide	endothelial nitric oxide synthase	MESH:D009569	4846	Chemical	Gene	synthase|amod|START_ENTITY Endothelial|amod|synthase role|nmod|Endothelial alterations|dep|role alterations|nmod|phosphorylation phosphorylation|amod|END_ENTITY	Cigarette smoke-induced alterations in endothelial_nitric_oxide_synthase phosphorylation : role of protein kinase C. Endothelial nitric_oxide synthase -LRB- eNOS -RRB- is regulated by phosphorylation of Ser -LRB- 1177 -RRB- and Thr -LRB- 495 -RRB- , which affects NO bioavailability .
18468205	0	nitric_oxide	120,132	endothelial_nitric_oxide_synthase	64,97	nitric oxide	endothelial nitric oxide synthase	MESH:D009569	4846	Chemical	Gene	levels|compound|START_ENTITY gene|nmod|levels gene|amod|END_ENTITY	Lack of evidence for contribution of intron4a/b polymorphism of endothelial_nitric_oxide_synthase -LRB- NOS3 -RRB- gene to plasma nitric_oxide levels .
18926858	0	nitric_oxide	83,95	endothelial_nitric_oxide_synthase	18,51	nitric oxide	endothelial nitric oxide synthase	MESH:D009569	4846	Chemical	Gene	muscle|nmod|START_ENTITY Autoinhibition|nmod|muscle Autoinhibition|nmod|END_ENTITY	Autoinhibition of endothelial_nitric_oxide_synthase -LRB- eNOS -RRB- in gut smooth muscle by nitric_oxide .
20038308	0	nitric_oxide	11,23	endothelial_nitric_oxide_synthase	37,70	nitric oxide	endothelial nitric oxide synthase	MESH:D009569	18127(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY derived|nsubj|Effect derived|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Effect of nitric_oxide derived from endothelial_nitric_oxide_synthase on tumor angiogenesis -RSB- .
20546771	0	nitric_oxide	26,38	endothelial_nitric_oxide_synthase	101,134	nitric oxide	endothelial nitric oxide synthase	MESH:D009569	4846	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Ginsenoside_Rg3 increases nitric_oxide production via increases in phosphorylation and expression of endothelial_nitric_oxide_synthase : essential roles of estrogen_receptor-dependent PI3-kinase and AMP-activated_protein_kinase .
20705923	0	nitric_oxide	65,77	endothelial_nitric_oxide_synthase	140,173	nitric oxide	endothelial nitric oxide synthase	MESH:D009569	4846	Chemical	Gene	production|compound|START_ENTITY antagonizes|dobj|production antagonizes|advcl|reversing reversing|dobj|acetylation acetylation|nmod|END_ENTITY	Histone_deacetylase_3 antagonizes aspirin-stimulated endothelial nitric_oxide production by reversing aspirin-induced lysine acetylation of endothelial_nitric_oxide_synthase .
22152956	0	nitric_oxide	135,147	endothelial_nitric_oxide_synthase	88,121	nitric oxide	endothelial nitric oxide synthase	MESH:D009569	18127(Tax:10090)	Chemical	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Beta3-adrenoreceptor stimulation ameliorates myocardial_ischemia-reperfusion injury via endothelial_nitric_oxide_synthase and neuronal nitric_oxide synthase activation .
22170035	0	nitric_oxide	50,62	endothelial_nitric_oxide_synthase	122,155	nitric oxide	endothelial nitric oxide synthase	MESH:D009569	18127(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY elevating|dobj|production elevating|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Syringaresinol causes vasorelaxation by elevating nitric_oxide production through the phosphorylation and dimerization of endothelial_nitric_oxide_synthase .
23148920	0	nitric_oxide	27,39	endothelial_nitric_oxide_synthase	88,121	nitric oxide	endothelial nitric oxide synthase	MESH:D009569	4846	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Hydrogen_sulfide increases nitric_oxide production with calcium-dependent activation of endothelial_nitric_oxide_synthase in endothelial cells .
23624269	0	nitric_oxide	21,33	endothelial_nitric_oxide_synthase	83,116	nitric oxide	endothelial nitric oxide synthase	MESH:D009569	4846	Chemical	Gene	production|amod|START_ENTITY attenuates|dobj|production attenuates|advcl|decreasing decreasing|dobj|interaction interaction|nmod|END_ENTITY	Uric_acid attenuates nitric_oxide production by decreasing the interaction between endothelial_nitric_oxide_synthase and calmodulin in human umbilical vein endothelial cells : a mechanism for uric_acid-induced cardiovascular_disease development .
23756809	0	nitric_oxide	41,53	endothelial_nitric_oxide_synthase	177,210	nitric oxide	endothelial nitric oxide synthase	MESH:D009569	4846	Chemical	Gene	production|amod|START_ENTITY increases|dobj|production increases|advcl|increasing increasing|dobj|Ca Ca|dep|phosphorylation phosphorylation|nmod|END_ENTITY	Far-infrared radiation acutely increases nitric_oxide production by increasing Ca -LRB- 2 + -RRB- mobilization and Ca -LRB- 2 + -RRB- / calmodulin-dependent_protein_kinase_II-mediated phosphorylation of endothelial_nitric_oxide_synthase at serine_1179 .
24403014	0	nitric_oxide	87,99	endothelial_nitric_oxide_synthase	19,52	nitric oxide	endothelial nitric oxide synthase	MESH:D009569	4846	Chemical	Gene	concentration|compound|START_ENTITY G894T|dobj|concentration G894T|nsubj|association association|nmod|gene gene|amod|END_ENTITY	The association of endothelial_nitric_oxide_synthase gene G894T polymorphism and serum nitric_oxide concentration with microalbuminuria in patients with gestational diabetes .
26367737	0	nitric_oxide	68,80	endothelial_nitric_oxide_synthase	116,149	nitric oxide	endothelial nitric oxide synthase	MESH:D009569	4846	Chemical	Gene	release|amod|START_ENTITY promotes|dobj|release promotes|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Piceatannol , a natural hydroxylated analog of resveratrol , promotes nitric_oxide release through phosphorylation of endothelial_nitric_oxide_synthase in human endothelial cells .
26393424	0	nitric_oxide	23,35	endothelial_nitric_oxide_synthase	92,125	nitric oxide	endothelial nitric oxide synthase	MESH:D009569	4846	Chemical	Gene	production|amod|START_ENTITY production|nmod|avb3-Akt-S6K-phosphorylation avb3-Akt-S6K-phosphorylation|nmod|END_ENTITY	CCN1 acutely increases nitric_oxide production via integrin avb3-Akt-S6K-phosphorylation of endothelial_nitric_oxide_synthase at the serine_1177 signaling axis .
9607805	0	nitric_oxide	12,24	endothelial_nitric_oxide_synthase	94,127	nitric oxide	endothelial nitric oxide synthase	MESH:D009569	18127(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY role|dep|abnormalities abnormalities|nmod|oocytes oocytes|amod|END_ENTITY	The role of nitric_oxide in oocyte meiotic maturation and ovulation : meiotic abnormalities of endothelial_nitric_oxide_synthase knock-out mouse oocytes .
10217661	0	nitric_oxide	130,142	endothelin-1	9,21	nitric oxide	endothelin-1	MESH:D009569	24323(Tax:10116)	Chemical	Gene	inhibition|amod|START_ENTITY synthesis|nmod|inhibition synthesis|nsubj|expression expression|amod|END_ENTITY	Vascular endothelin-1 gene expression and synthesis and effect on renal type I collagen synthesis and nephroangiosclerosis during nitric_oxide synthase inhibition in rats .
10386227	0	nitric_oxide	90,102	endothelin-1	11,23	nitric oxide	endothelin-1	MESH:D009569	24323(Tax:10116)	Chemical	Gene	modulated|nmod|START_ENTITY modulated|nsubjpass|Actions Actions|nmod|cells cells|amod|END_ENTITY	Actions of endothelin-1 on cultured rat renomedullary interstitial cells are modulated by nitric_oxide .
10408023	6	nitric_oxide	886,898	endothelin-1	980,992	nitric oxide	endothelin-1	MESH:D009569	1906	Chemical	Gene	interactions|nmod|START_ENTITY indication|nmod|interactions indicated|nsubjpass|indication indicated|ccomp|inhibited inhibited|nsubj|antagonists antagonists|amod|END_ENTITY	Further indication of functional interactions between nitric_oxide and endothelin-1 in postischemic reperfusion were indicated by observations that endothelin-1 antagonists inhibited early hypoperfusion caused by Nitro-L-arginin and late hypoperfusion caused by endogenous endothelin-1 .
10423059	0	nitric_oxide	38,50	endothelin-1	8,20	nitric oxide	endothelin-1	MESH:D009569	24323(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY synthase|amod|END_ENTITY	Role of endothelin-1 and constitutive nitric_oxide synthase in gastric mucosal resistance to indomethacin injury : effect of antiulcer agents .
10519149	0	nitric_oxide	44,56	endothelin-1	74,86	nitric oxide	endothelin-1	MESH:D009569	1906	Chemical	Gene	regulation|nmod|START_ENTITY synthase|nsubj|regulation synthase|nmod|END_ENTITY	Tyrosine-kinase-dependent regulation of the nitric_oxide synthase gene by endothelin-1 in human endothelial cells .
10678275	0	nitric_oxide	95,107	endothelin-1	14,26	nitric oxide	endothelin-1	MESH:D009569	24323(Tax:10116)	Chemical	Gene	system|amod|START_ENTITY hypertensive|nmod|system hypertensive|nsubj|Modulation Modulation|nmod|vasoconstriction vasoconstriction|amod|END_ENTITY	Modulation of endothelin-1 coronary vasoconstriction in spontaneously hypertensive rats by the nitric_oxide system .
10954044	0	nitric_oxide	14,26	endothelin-1	74,86	nitric oxide	endothelin-1	MESH:D009569	1906	Chemical	Gene	START_ENTITY|nmod|cells cells|nmod|END_ENTITY	Production of nitric_oxide from endothelial cells by 31-amino-acid-length endothelin-1 , a novel vasoconstrictive product by human chymase .
11065212	0	nitric_oxide	23,35	endothelin-1	50,62	nitric oxide	endothelin-1	MESH:D009569	24323(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY Increase|nmod|metabolism Increase|nmod|END_ENTITY	Increase in neurogenic nitric_oxide metabolism by endothelin-1 in mesenteric arteries from hypertensive rats .
11162595	0	nitric_oxide	69,81	endothelin-1	21,33	nitric oxide	endothelin-1	MESH:D009569	281137(Tax:9913)	Chemical	Gene	increases|nmod|START_ENTITY increases|xcomp|END_ENTITY	Hemoglobin increases endothelin-1 in endothelial cells by decreasing nitric_oxide .
11172478	0	nitric_oxide	63,75	endothelin-1	19,31	nitric oxide	endothelin-1	MESH:D009569	24323(Tax:10116)	Chemical	Gene	levels|amod|START_ENTITY vascular|nmod|levels vascular|dobj|expression expression|amod|END_ENTITY	Increased vascular endothelin-1 gene expression with unaltered nitric_oxide synthase levels in fructose-induced hypertensive rats .
11265035	0	nitric_oxide	17,29	endothelin-1	55,67	nitric oxide	endothelin-1	MESH:D009569	24323(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY release|nmod|permeability permeability|amod|END_ENTITY	Basal release of nitric_oxide and its interaction with endothelin-1 on single vessel hydraulic permeability .
11588325	0	nitric_oxide	72,84	endothelin-1	20,32	nitric oxide	endothelin-1	MESH:D009569	100009270(Tax:9986)	Chemical	Gene	sensitivity|acl|START_ENTITY reduces|dobj|sensitivity reduces|nsubj|END_ENTITY	Endothelium-derived endothelin-1 reduces cerebral artery sensitivity to nitric_oxide by a protein_kinase_C-independent pathway .
11589785	0	nitric_oxide	42,54	endothelin-1	17,29	nitric oxide	endothelin-1	MESH:D009569	24323(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|plasma plasma|amod|END_ENTITY	Increased plasma endothelin-1 and cardiac nitric_oxide during doxorubicin-induced cardiomyopathy .
11751199	0	nitric_oxide	10,22	endothelin-1	56,68	nitric oxide	endothelin-1	MESH:D009569	24323(Tax:10116)	Chemical	Gene	supplementation|amod|START_ENTITY Timing|nmod|supplementation determines|nsubj|Timing determines|dobj|regulation regulation|amod|END_ENTITY	Timing of nitric_oxide donor supplementation determines endothelin-1 regulation and quality of lung preservation for transplantation .
11842053	0	nitric_oxide	66,78	endothelin-1	26,38	nitric oxide	endothelin-1	MESH:D009569	24323(Tax:10116)	Chemical	Gene	unaltered|nmod|START_ENTITY unaltered|nsubj|expression expression|amod|END_ENTITY	Hypoxia-induced pulmonary endothelin-1 expression is unaltered by nitric_oxide .
11902294	0	nitric_oxide	8,20	endothelin-1	31,43	nitric oxide	endothelin-1	MESH:D009569	1906	Chemical	Gene	increases|compound|START_ENTITY increases|dep|levels levels|amod|END_ENTITY	Inhaled nitric_oxide increases endothelin-1 levels : a potential cause of rebound pulmonary_hypertension .
12100751	0	nitric_oxide	42,54	endothelin-1	28,40	nitric oxide	endothelin-1	MESH:D009569	100009270(Tax:9986)	Chemical	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	Effects of xiaoyu tablet on endothelin-1 , nitric_oxide , and apoptotic cells of atherosclerotic vessel wall in rabbits .
12193107	0	nitric_oxide	51,63	endothelin-1	26,38	nitric oxide	endothelin-1	MESH:D009569	1906	Chemical	Gene	START_ENTITY|nsubj|Interaction Interaction|nmod|endogenous endogenous|amod|END_ENTITY	Interaction of endogenous endothelin-1 and inhaled nitric_oxide in term and preterm infants .
12193116	0	nitric_oxide	73,85	endothelin-1	46,58	nitric oxide	endothelin-1	MESH:D009569	24323(Tax:10116)	Chemical	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Effects of endothelin receptor antagonists on endothelin-1 and inducible nitric_oxide synthase genes in a rat endotoxic_shock model .
12584267	0	nitric_oxide	12,24	endothelin-1	74,86	nitric oxide	endothelin-1	MESH:D009569	13614(Tax:10090)	Chemical	Gene	bioavailability|amod|START_ENTITY Increase|nmod|bioavailability improves|nsubj|Increase improves|dobj|function function|nmod|transgenic_mice transgenic_mice|amod|END_ENTITY	Increase in nitric_oxide bioavailability improves endothelial function in endothelin-1 transgenic_mice .
1282961	0	nitric_oxide	42,54	endothelin-1	11,23	nitric oxide	endothelin-1	MESH:D009569	24323(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY Effects|nmod|production Effects|nmod|END_ENTITY	Effects of endothelin-1 and inhibition of nitric_oxide production with NG-monomethyl-L-arginine on arterial pressure and regional blood flow in anesthetized rats .
12871749	0	nitric_oxide	83,95	endothelin-1	56,68	nitric oxide	endothelin-1	MESH:D009569	1906	Chemical	Gene	role|nmod|START_ENTITY role|nmod|regulation regulation|nmod|production production|amod|END_ENTITY	The role of nuclear factor-kappa B in the regulation of endothelin-1 production by nitric_oxide .
12970246	0	nitric_oxide	61,73	endothelin-1	26,38	nitric oxide	endothelin-1	MESH:D009569	1906	Chemical	Gene	inhalation|amod|START_ENTITY circulating|nmod|inhalation circulating|dobj|endothelin endothelin|amod|END_ENTITY	Modulation of circulating endothelin-1 and big endothelin by nitric_oxide inhalation following left ventricular assist device implantation .
15193775	0	nitric_oxide	57,69	endothelin-1	30,42	nitric oxide	endothelin-1	MESH:D009569	24323(Tax:10116)	Chemical	Gene	underlies|amod|START_ENTITY underlies|amod|END_ENTITY	Intracellular coexpression of endothelin-1 and inducible nitric_oxide synthase underlies hypoperfusion after traumatic_brain_injury in the rat .
15273750	0	nitric_oxide	119,131	endothelin-1	85,97	nitric oxide	endothelin-1	MESH:D009569	13614(Tax:10090)	Chemical	Gene	inhibition|nmod|START_ENTITY END_ENTITY|nmod|inhibition	Effect of cholinergic and adrenergic receptor blockade on arrhythmogenic activity of endothelin-1 during inhibition of nitric_oxide synthesis in awake mice .
15518706	0	nitric_oxide	16,28	endothelin-1	49,61	nitric oxide	endothelin-1	MESH:D009569	24323(Tax:10116)	Chemical	Gene	donor|amod|START_ENTITY donor|nmod|expression expression|amod|END_ENTITY	The effect of a nitric_oxide donor on endogenous endothelin-1 expression in renal_ischemia / reperfusion injury .
15576270	0	nitric_oxide	11,23	endothelin-1	72,84	nitric oxide	endothelin-1	MESH:D009569	100294653(Tax:9940)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of nitric_oxide and prostacyclin on hemodynamic response by big endothelin-1 in near term fetal sheep .
15758251	0	nitric_oxide	78,90	endothelin-1	121,133	nitric oxide	endothelin-1	MESH:D009569	1906	Chemical	Gene	production|amod|START_ENTITY inhibition|nmod|production inhibition|nmod|release release|amod|END_ENTITY	Phytoestrogen alpha-zearalanol antagonizes oxidized LDL-induced inhibition of nitric_oxide production and stimulation of endothelin-1 release in human umbilical vein endothelial cells .
15838302	0	nitric_oxide	9,21	endothelin-1	87,99	nitric oxide	endothelin-1	MESH:D009569	24323(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY buffers|nsubj|activity buffers|dobj|secretion secretion|amod|END_ENTITY	Neuronal nitric_oxide synthase activity in the paraventricular nucleus buffers central endothelin-1 - induced pressor response and vasopressin secretion .
15838348	0	nitric_oxide	15,27	endothelin-1	77,89	nitric oxide	endothelin-1	MESH:D009569	24323(Tax:10116)	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|effect effect|nmod|17beta-estradiol 17beta-estradiol|nmod|overproduction overproduction|amod|END_ENTITY	Involvement of nitric_oxide in the suppressive effect of 17beta-estradiol on endothelin-1 overproduction in ischemic acute_renal_failure .
16005006	0	nitric_oxide	7,19	endothelin-1	21,33	nitric oxide	endothelin-1	MESH:D009569	1906	Chemical	Gene	START_ENTITY|appos|levels levels|amod|END_ENTITY	Plasma nitric_oxide , endothelin-1 and urinary nitric_oxide and cyclic_guanosine_monophosphate levels in hypertensive pregnant women .
1628160	0	nitric_oxide	12,24	endothelin-1	64,76	nitric oxide	endothelin-1	MESH:D009569	24323(Tax:10116)	Chemical	Gene	effects|amod|START_ENTITY role|nmod|effects role|nmod|END_ENTITY	The role of nitric_oxide in the regional vasodilator effects of endothelin-1 in the rat .
16820593	0	nitric_oxide	36,48	endothelin-1	9,21	nitric oxide	endothelin-1	MESH:D009569	1906	Chemical	Gene	homeostasis|amod|START_ENTITY impair|dobj|homeostasis impair|nsubj|levels levels|amod|END_ENTITY	Elevated endothelin-1 levels impair nitric_oxide homeostasis through a PKC-dependent pathway .
17105827	0	nitric_oxide	111,123	endothelin-1	83,95	nitric oxide	endothelin-1	MESH:D009569	1906	Chemical	Gene	signaling|amod|START_ENTITY production|nmod|signaling production|amod|END_ENTITY	peroxisome_proliferator-activated_receptor_alpha activation-mediated regulation of endothelin-1 production via nitric_oxide and protein_kinase_C signaling pathways in piglet cerebral microvascular endothelial cell culture .
17662977	0	nitric_oxide	68,80	endothelin-1	41,53	nitric oxide	endothelin-1	MESH:D009569	24323(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Air pollution alters brain and pituitary endothelin-1 and inducible nitric_oxide synthase gene expression .
19415172	0	nitric_oxide	66,78	endothelin-1	18,30	nitric oxide	endothelin-1	MESH:D009569	100009270(Tax:9986)	Chemical	Gene	fluid|nmod|START_ENTITY END_ENTITY|nmod|fluid	Elevated level of endothelin-1 in cerebrospinal fluid and lack of nitric_oxide in basilar arterial plasma associated with cerebral_vasospasm after subarachnoid_haemorrhage in rabbits .
19764340	0	nitric_oxide	14,26	endothelin-1	53,65	nitric oxide	endothelin-1	MESH:D009569	1906	Chemical	Gene	gas|amod|START_ENTITY gas|nmod|expression expression|nmod|nitric_oxide nitric_oxide|amod|END_ENTITY	Alteration of nitric_oxide gas on gene expression of endothelin-1 and endothelial nitric_oxide synthase by a time - and dose-dependent manner in human endothelial cells .
19779116	0	nitric_oxide	118,130	endothelin-1	104,116	nitric oxide	endothelin-1	MESH:D009569	1906	Chemical	Gene	synthase|amod|START_ENTITY synthase|amod|END_ENTITY	Genetic determinants of cardiovascular_disease : the renin-angiotensin-aldosterone system , paraoxonases , endothelin-1 , nitric_oxide synthase and adrenergic receptors .
20690982	0	nitric_oxide	55,67	endothelin-1	14,26	nitric oxide	endothelin-1	MESH:D009569	24323(Tax:10116)	Chemical	Gene	dilation|amod|START_ENTITY improves|dobj|dilation improves|nsubj|Inhibition Inhibition|nmod|receptors receptors|amod|END_ENTITY	Inhibition of endothelin-1 receptors improves impaired nitric_oxide synthase-dependent dilation of cerebral arterioles in type-1 diabetic rats .
20929026	0	nitric_oxide	84,96	endothelin-1	22,34	nitric oxide	endothelin-1	MESH:D009569	1906	Chemical	Gene	therapy|compound|START_ENTITY Correlation|nmod|therapy Correlation|nmod|levels levels|amod|END_ENTITY	Correlation of plasma endothelin-1 levels with pulmonary_hypertension after inhaled nitric_oxide therapy .
21448844	0	nitric_oxide	95,107	endothelin-1	25,37	nitric oxide	endothelin-1	MESH:D009569	24323(Tax:10116)	Chemical	Gene	impairs|nmod|START_ENTITY impairs|dobj|vasoconstriction vasoconstriction|amod|END_ENTITY	High fat feeding impairs endothelin-1 mediated vasoconstriction through increased iNOS-derived nitric_oxide .
21777087	0	nitric_oxide	162,174	endothelin-1	147,159	nitric oxide	endothelin-1	MESH:D009569	24323(Tax:10116)	Chemical	Gene	ratio|compound|START_ENTITY ratio|amod|END_ENTITY	Human recombinant erythropoietin alters the flow-dependent vasodilatation of in vitro perfused rat mesenteric arteries with unbalanced endothelial endothelin-1 / nitric_oxide ratio .
22805284	0	nitric_oxide	161,173	endothelin-1	23,35	nitric oxide	endothelin-1	MESH:D009569	100034060(Tax:9796)	Chemical	Gene	administered|nmod|START_ENTITY administered|nsubj|concentrations concentrations|amod|END_ENTITY	Oxygenation and plasma endothelin-1 concentrations in healthy horses recovering from isoflurane anaesthesia administered with or without pulse-delivered inhaled nitric_oxide .
24578389	0	nitric_oxide	62,74	endothelin-1	49,61	nitric oxide	endothelin-1	MESH:D009569	1906	Chemical	Gene	imbalance|compound|START_ENTITY imbalance|amod|END_ENTITY	Tumour necrosis factor-alpha participates on the endothelin-1 / nitric_oxide imbalance in small arteries from obese patients : role of perivascular adipose tissue .
7498555	0	nitric_oxide	54,66	endothelin-1	93,105	nitric oxide	endothelin-1	MESH:D009569	1906	Chemical	Gene	role|nmod|START_ENTITY reveals|dobj|role reveals|parataxis|not not|nmod|secretion secretion|amod|END_ENTITY	Novel guanylyl cyclase inhibitor , ODQ reveals role of nitric_oxide , but not of cyclic_GMP in endothelin-1 secretion .
7501245	0	nitric_oxide	25,37	endothelin-1	81,93	nitric oxide	endothelin-1	MESH:D009569	24323(Tax:10116)	Chemical	Gene	demonstration|nmod|START_ENTITY demonstration|dep|effects effects|nmod|injection injection|amod|END_ENTITY	Ex vivo demonstration of nitric_oxide in the rat brain : effects of intrastriatal endothelin-1 injection .
7515230	0	nitric_oxide	11,23	endothelin-1	34,46	nitric oxide	endothelin-1	MESH:D009569	281137(Tax:9913)	Chemical	Gene	modulates|advmod|START_ENTITY modulates|dobj|contraction contraction|amod|END_ENTITY	Endogenous nitric_oxide modulates endothelin-1 induced contraction of bovine oviduct .
7867388	0	nitric_oxide	14,26	endothelin-1	64,76	nitric oxide	endothelin-1	MESH:D009569	13614(Tax:10090)	Chemical	Gene	synthesis|amod|START_ENTITY Inhibition|nmod|synthesis increases|nsubj|Inhibition increases|dobj|secretion secretion|nmod|cells cells|amod|END_ENTITY	Inhibition of nitric_oxide synthesis increases the secretion of endothelin-1 in vivo and in cultured endothelial cells .
8026008	0	nitric_oxide	66,78	endothelin-1	137,149	nitric oxide	endothelin-1	MESH:D009569	1906	Chemical	Gene	inhibition|nmod|START_ENTITY response|nmod|inhibition administered|nsubj|response administered|xcomp|END_ENTITY	Diminished vascular response to inhibition of endothelium-derived nitric_oxide and enhanced vasoconstriction to exogenously administered endothelin-1 in clinically healthy smokers .
8102933	0	nitric_oxide	102,114	endothelin-1	13,25	nitric oxide	endothelin-1	MESH:D009569	100726197	Chemical	Gene	role|nmod|START_ENTITY Induction|dep|role Induction|nmod|END_ENTITY	Induction by endothelin-1 of epithelium-dependent relaxation of guinea-pig trachea in vitro : role for nitric_oxide .
8298811	0	nitric_oxide	59,71	endothelin-1	22,34	nitric oxide	endothelin-1	MESH:D009569	24323(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY inhibition|nmod|synthesis inhibition|amod|END_ENTITY	Vascular responses to endothelin-1 following inhibition of nitric_oxide synthesis in the conscious rat .
8566099	0	nitric_oxide	72,84	endothelin-1	8,20	nitric oxide	endothelin-1	MESH:D009569	24323(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY inhibition|nmod|synthase induced|nmod|inhibition induced|nsubj|Role Role|nmod|END_ENTITY	Role of endothelin-1 in hypertension induced by long-term inhibition of nitric_oxide synthase .
8566233	0	nitric_oxide	49,61	endothelin-1	80,92	nitric oxide	endothelin-1	MESH:D009569	24323(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|release release|nmod|gland gland|amod|END_ENTITY	Differential effects of endogenous and exogenous nitric_oxide on the release of endothelin-1 from the intact perfused rat adrenal gland in situ .
8587364	0	nitric_oxide	74,86	endothelin-1	23,35	nitric oxide	endothelin-1	MESH:D009569	24323(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY effect|dep|role effect|nmod|flow flow|amod|END_ENTITY	Differential effect of endothelin-1 on renal regional blood flow : role of nitric_oxide .
8729059	0	nitric_oxide	71,83	endothelin-1	14,26	nitric oxide	endothelin-1	MESH:D009569	24323(Tax:10116)	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|effects effects|amod|END_ENTITY	Modulation of endothelin-1 effects on rat hearts and cardiomyocytes by nitric_oxide and 8-bromo_cyclic_GMP .
8756010	0	nitric_oxide	26,38	endothelin-1	76,88	nitric oxide	endothelin-1	MESH:D009569	24323(Tax:10116)	Chemical	Gene	synthase|compound|START_ENTITY Depression|nmod|synthase Depression|nmod|immunoreactivity immunoreactivity|amod|END_ENTITY	Depression of endothelial nitric_oxide synthase but increased expression of endothelin-1 immunoreactivity in rat thoracic aortic endothelium associated with long-term , but not short-term , sympathectomy .
8765273	0	nitric_oxide	10,22	endothelin-1	100,112	nitric oxide	endothelin-1	MESH:D009569	24323(Tax:10116)	Chemical	Gene	blockade|compound|START_ENTITY blockade|dep|effects effects|nmod|END_ENTITY	Long-term nitric_oxide blockade in the pregnant rat : effects on blood pressure and plasma levels of endothelin-1 .
8788598	0	nitric_oxide	99,111	endothelin-1	69,81	nitric oxide	endothelin-1	MESH:D009569	1906	Chemical	Gene	synthase|amod|START_ENTITY synthase|amod|END_ENTITY	Recombinant human erythropoietin does not regulate the expression of endothelin-1 and constitutive nitric_oxide synthase in vascular endothelial cells .
9211172	0	nitric_oxide	20,32	endothelin-1	61,73	nitric oxide	endothelin-1	MESH:D009569	24323(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY blockade|nmod|synthesis increases|nsubj|blockade increases|dobj|excretion excretion|amod|END_ENTITY	Chronic blockade of nitric_oxide synthesis increases urinary endothelin-1 excretion .
9286621	0	nitric_oxide	5,17	endothelin-1	83,95	nitric oxide	endothelin-1	MESH:D009569	1906	Chemical	Gene	contribute|nsubj|START_ENTITY contribute|nmod|effects effects|nmod|END_ENTITY	Does nitric_oxide contribute to the negative chronotropic and inotropic effects of endothelin-1 in the heart ?
9413859	0	nitric_oxide	85,97	endothelin-1	27,39	nitric oxide	endothelin-1	MESH:D009569	24323(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY Contribution|dep|role Contribution|nmod|endogenous endogenous|amod|END_ENTITY	Contribution of endogenous endothelin-1 to the maintenance of vascular tone : role of nitric_oxide .
9415517	0	nitric_oxide	93,105	endothelin-1	28,40	nitric oxide	endothelin-1	MESH:D009569	1906	Chemical	Gene	synthase|amod|START_ENTITY constitutive|dobj|synthase constitutive|nsubj|expression expression|nmod|receptor receptor|amod|END_ENTITY	Messenger RNA expression of endothelin-1 , endothelin-A receptor and endothelial constitutive nitric_oxide synthase in hydatididorm moles .
9488222	0	nitric_oxide	149,161	endothelin-1	42,54	nitric oxide	endothelin-1	MESH:D009569	24323(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY reduces|parataxis|role reduces|nmod|END_ENTITY	Losartan reduces constrictor responses to endothelin-1 and the thromboxane_A2 analogue in aortic rings from spontaneously hypertensive rats : role of nitric_oxide .
9595494	0	nitric_oxide	53,65	endothelin-1	19,31	nitric oxide	endothelin-1	MESH:D009569	24323(Tax:10116)	Chemical	Gene	rats/Izm|amod|START_ENTITY rats/Izm|amod|END_ENTITY	Gene expression of endothelin-1 and endothelial-type nitric_oxide synthase in cardiovascular tissues of stroke-prone spontaneously hypertensive rats/Izm : effects of the angiotensin-converting enzyme inhibitor aracepril .
9637705	0	nitric_oxide	148,160	endothelin-1	119,131	nitric oxide	endothelin-1	MESH:D009569	281137(Tax:9913)	Chemical	Gene	synthase|amod|START_ENTITY synthase|amod|END_ENTITY	Effects of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors , atorvastatin and simvastatin , on the expression of endothelin-1 and endothelial nitric_oxide synthase in vascular endothelial cells .
9638794	0	nitric_oxide	108,120	endothelin-1	79,91	nitric oxide	endothelin-1	MESH:D009569	24323(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY synthase|amod|END_ENTITY	Type V phosphodiesterase inhibition modulates endogenous immunoreactivities of endothelin-1 and endothelial nitric_oxide synthase in pulmonary arteries in rats with monocrotaline-induced pulmonary_hypertension .
9736792	0	nitric_oxide	10,22	endothelin-1	23,35	nitric oxide	endothelin-1	MESH:D009569	1906	Chemical	Gene	START_ENTITY|parataxis|endotheliocytes endotheliocytes|nsubj|equilibrium equilibrium|amod|END_ENTITY	Disturbed nitric_oxide / endothelin-1 equilibrium in cultured human placental endotheliocytes in preeclampsia .
9866120	0	nitric_oxide	87,99	endothelin-1	57,69	nitric oxide	endothelin-1	MESH:D009569	24323(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY inhibition|nmod|synthesis END_ENTITY|nmod|inhibition	Potentiation of pulmonary arteriolar vasoconstriction to endothelin-1 by inhibition of nitric_oxide synthesis in the intact lung .
9920186	0	nitric_oxide	36,48	endothelin-1	52,64	nitric oxide	endothelin-1	MESH:D009569	1906	Chemical	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Effects of endogenous and exogenous nitric_oxide on endothelin-1 production in cultured vascular endothelial cells .
11321515	0	nitric_oxide	141,153	endothelin-converting_enzyme-1	93,123	nitric oxide	endothelin-converting enzyme-1	MESH:D009569	94204(Tax:10116)	Chemical	Gene	synthase|compound|START_ENTITY synthase|amod|END_ENTITY	Nonsteroidal anti-inflammatory drugs impair oral mucosal repair by eliciting disturbances in endothelin-converting_enzyme-1 and constitutive nitric_oxide synthase .
8993007	0	nitric_oxide	70,82	endothelin_B	40,52	nitric oxide	endothelin B	MESH:D009569	1910	Chemical	Gene	release|compound|START_ENTITY release|amod|END_ENTITY	Human monocyte adhesion is modulated by endothelin_B receptor-coupled nitric_oxide release .
12438523	0	nitric_oxide	15,27	enkephalin	73,83	nitric oxide	enkephalin	MESH:D009569	29237(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY END_ENTITY|nsubj|Role	Role of spinal nitric_oxide in the inhibitory effect of -LSB- D-Pen2 , D-Pen5 -RSB- - enkephalin on ascending dorsal horn neurons in normal and diabetic rats .
10718107	0	nitric_oxide	108,120	epidermal_growth_factor	14,37	nitric oxide	epidermal growth factor	MESH:D009569	25313(Tax:10116)	Chemical	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|effect effect|nmod|END_ENTITY	The effect of epidermal_growth_factor on prostaglandin synthesis of oestrogenized rat uterus is mediated by nitric_oxide .
10193805	0	nitric_oxide	71,83	erythropoietin	18,32	nitric oxide	erythropoietin	MESH:D009569	24335(Tax:10116)	Chemical	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Human recombinant erythropoietin inhibits interleukin-1beta-stimulated nitric_oxide and cyclic_guanosine_monophosphate production in cultured rat vascular smooth-muscle cells .
10489101	0	nitric_oxide	71,83	erythropoietin	14,28	nitric oxide	erythropoietin	MESH:D009569	2056	Chemical	Gene	synthesis|amod|START_ENTITY mediated|nmod|synthesis mediated|nsubj|effect effect|nmod|END_ENTITY	The effect of erythropoietin on interleukin-1beta mediated increase in nitric_oxide synthesis in vascular smooth muscle cells .
10678740	0	nitric_oxide	11,23	erythropoietin	35,49	nitric oxide	erythropoietin	MESH:D009569	13856(Tax:10090)	Chemical	Gene	attenuates|advmod|START_ENTITY attenuates|dobj|expression expression|compound|END_ENTITY	Endogenous nitric_oxide attenuates erythropoietin gene expression in vivo .
10746825	0	nitric_oxide	20,32	erythropoietin	129,143	nitric oxide	erythropoietin	MESH:D009569	2056	Chemical	Gene	generation|amod|START_ENTITY changes|nmod|generation treated|nsubj|changes treated|nmod|END_ENTITY	Biphasic changes in nitric_oxide generation in hemodialyzed patients with end-stage_renal_disease treated with recombinant human erythropoietin .
14631167	0	nitric_oxide	24,36	erythropoietin	134,148	nitric oxide	erythropoietin	MESH:D009569	24335(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|parataxis|it it|nsubj|explanation explanation|nmod|role role|nmod|END_ENTITY	Selective inhibition of nitric_oxide in hypoxic-ischemic_brain model in newborn rats : is it an explanation for the protective role of erythropoietin ?
15450363	0	nitric_oxide	28,40	erythropoietin	10,24	nitric oxide	erythropoietin	MESH:D009569	24335(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	Effect of erythropoietin on nitric_oxide production in the rat hippocampus using in vivo brain microdialysis .
17372034	0	nitric_oxide	30,42	erythropoietin	75,89	nitric oxide	erythropoietin	MESH:D009569	13856(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY synthase|nsubj|role synthase|nmod|effects effects|nmod|END_ENTITY	Essential role of endothelial nitric_oxide synthase in vascular effects of erythropoietin .
20806411	0	nitric_oxide	44,56	erythropoietin	17,31	nitric oxide	erythropoietin	MESH:D009569	13856(Tax:10090)	Chemical	Gene	receptor|nmod|START_ENTITY receptor|compound|END_ENTITY	Up-regulation of erythropoietin receptor by nitric_oxide mediates hypoxia preconditioning .
21296066	0	nitric_oxide	111,123	erythropoietin	18,32	nitric oxide	erythropoietin	MESH:D009569	2056	Chemical	Gene	ameliorated|nmod|START_ENTITY ameliorated|nsubj|END_ENTITY	Recombinant human erythropoietin ameliorated endothelial_dysfunction and macrophage infiltration by increasing nitric_oxide in hypertensive 5/6 nephrectomized rat aorta .
21321940	0	nitric_oxide	87,99	erythropoietin	33,47	nitric oxide	erythropoietin	MESH:D009569	280784(Tax:9913)	Chemical	Gene	synthase|compound|START_ENTITY activation|nmod|synthase signaling|nmod|activation END_ENTITY|acl|signaling	b Common receptor integrates the erythropoietin signaling in activation of endothelial nitric_oxide synthase .
21777087	0	nitric_oxide	162,174	erythropoietin	18,32	nitric oxide	erythropoietin	MESH:D009569	24335(Tax:10116)	Chemical	Gene	ratio|compound|START_ENTITY alters|nmod|ratio alters|nsubj|END_ENTITY	Human recombinant erythropoietin alters the flow-dependent vasodilatation of in vitro perfused rat mesenteric arteries with unbalanced endothelial endothelin-1 / nitric_oxide ratio .
24744892	0	nitric_oxide	41,53	erythropoietin	19,33	nitric oxide	erythropoietin	MESH:D009569	13856(Tax:10090)	Chemical	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	Catalyzing role of erythropoietin on the nitric_oxide central pathway during the ventilatory responses to hypoxia .
25346735	0	nitric_oxide	12,24	erythropoietin	74,88	nitric oxide	erythropoietin	MESH:D009569	13856(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY mediates|nsubj|synthase mediates|dobj|effects effects|nmod|END_ENTITY	Endothelial nitric_oxide synthase mediates the cerebrovascular effects of erythropoietin in traumatic_brain_injury .
7623992	0	nitric_oxide	106,118	erythropoietin	40,54	nitric oxide	erythropoietin	MESH:D009569	2056	Chemical	Gene	system|compound|START_ENTITY activity|nmod|system due|nmod|activity due|nsubj|effect effect|nmod|END_ENTITY	The pressor effect of recombinant human erythropoietin is not due to decreased activity of the endogenous nitric_oxide system .
8397229	0	nitric_oxide	15,27	erythropoietin	72,86	nitric oxide	erythropoietin	MESH:D009569	2056	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|dep|monophosphate monophosphate|nmod|production production|compound|END_ENTITY	Interaction of nitric_oxide and cyclic_guanosine_3 ' ,5 ' - monophosphate in erythropoietin production .
8788598	0	nitric_oxide	99,111	erythropoietin	18,32	nitric oxide	erythropoietin	MESH:D009569	2056	Chemical	Gene	synthase|amod|START_ENTITY expression|nmod|synthase regulate|dobj|expression regulate|nsubj|END_ENTITY	Recombinant human erythropoietin does not regulate the expression of endothelin-1 and constitutive nitric_oxide synthase in vascular endothelial cells .
9350067	0	nitric_oxide	53,65	erythropoietin	8,22	nitric oxide	erythropoietin	MESH:D009569	24335(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY enhances|dobj|production enhances|nsubj|treatment treatment|compound|END_ENTITY	Chronic erythropoietin treatment enhances endogenous nitric_oxide production in rats .
15308732	0	nitric_oxide	24,36	extracellular_signal-regulated_kinases_1_and_2	124,170	nitric oxide	extracellular signal-regulated kinases 1 and 2	MESH:D009569	5595	Chemical	Gene	production|amod|START_ENTITY stimulates|dobj|production stimulates|nmod|activation activation|nmod|END_ENTITY	Rabies_virus stimulates nitric_oxide production and CXC_chemokine_ligand_10 expression in macrophages through activation of extracellular_signal-regulated_kinases_1_and_2 .
18227383	0	nitric_oxide	130,142	extracellular_signal-regulated_kinases_1_and_2	67,113	nitric oxide	extracellular signal-regulated kinases 1 and 2	MESH:D009569	50689;116590	Chemical	Gene	synthase|amod|START_ENTITY synthase|amod|END_ENTITY	Adenosine modulates cardiovascular functions through activation of extracellular_signal-regulated_kinases_1_and_2 and endothelial nitric_oxide synthase in the nucleus tractus solitarii of rats .
11109002	0	nitric_oxide	43,55	fos	26,29	nitric oxide	fos	MESH:D009569	314322(Tax:10116)	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Hypobaric_hypoxia induces fos and neuronal nitric_oxide synthase expression in the paraventricular and supraoptic nucleus in rats .
11442774	0	nitric_oxide	10,22	fos	46,49	nitric oxide	fos	MESH:D009569	314322(Tax:10116)	Chemical	Gene	inhibition|amod|START_ENTITY Effect|nmod|inhibition Effect|nmod|expression expression|compound|END_ENTITY	Effect of nitric_oxide synthase inhibition on fos expression in the hypothalamus of female rats following central oxytocin and systemic urethane administration .
15946655	0	nitric_oxide	68,80	gamma-glutamyl_transpeptidase	141,170	nitric oxide	gamma-glutamyl transpeptidase	MESH:D009569	116568(Tax:10116)	Chemical	Gene	levels|nmod|START_ENTITY levels|nmod|END_ENTITY	Treatment with 1,2,3,4-tetrahydroisoquinolone affects the levels of nitric_oxide , S-nitrosothiols , glutathione and the enzymatic activity of gamma-glutamyl_transpeptidase in the dopaminergic structures of rat brain .
19552953	0	nitric_oxide	12,24	ghrelin	53,60	nitric oxide	ghrelin	MESH:D009569	59301(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|effect effect|nmod|END_ENTITY	The role of nitric_oxide in the inhibitory effect of ghrelin against penicillin-induced epileptiform_activity in rat .
24333973	0	nitric_oxide	90,102	ghrelin	10,17	nitric oxide	ghrelin	MESH:D009569	59301(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY Effect|dep|role Effect|nmod|END_ENTITY	Effect of ghrelin on chronic_liver_injury and fibrogenesis in male rats : possible role of nitric_oxide .
21047628	0	nitric_oxide	124,136	glucocorticoid_receptor	8,31	nitric oxide	glucocorticoid receptor	MESH:D009569	2908	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of glucocorticoid_receptor in the inhibitory effect of medroxyprogesterone_acetate on the estrogen-induced endothelial nitric_oxide synthase phosphorylation in human umbilical vein endothelial cells .
12707306	0	nitric_oxide	76,88	glucokinase	24,35	nitric oxide	glucokinase	MESH:D009569	2645	Chemical	Gene	synthase|amod|START_ENTITY END_ENTITY|nmod|synthase	Regulation of beta cell glucokinase by S-nitrosylation and association with nitric_oxide synthase .
16112416	0	nitric_oxide	137,149	glutathione-S-transferase	24,49	nitric oxide	glutathione-S-transferase	MESH:D009569	373156	Chemical	Gene	oxidase|advmod|START_ENTITY oxidase|amod|END_ENTITY	Glutathione peroxidase , glutathione-S-transferase , catalase , xanthine oxidase , Cu-Zn_superoxide dismutase activities , total glutathione , nitric_oxide , and malondialdehyde levels in erythrocytes of patients with small cell and non-small_cell_lung_cancer .
9393673	0	nitric_oxide	35,47	glutathione_reductase	101,122	nitric oxide	glutathione reductase	MESH:D009569	2936	Chemical	Gene	START_ENTITY|dobj|inhibitors inhibitors|nmod|END_ENTITY	Dinitrosyl-dithiol-iron complexes , nitric_oxide -LRB- NO -RRB- carriers in vivo , as potent inhibitors of human glutathione_reductase and glutathione-S-transferase .
7540026	0	nitric_oxide	87,99	glyceraldehyde-3-phosphate_dehydrogenase	30,70	nitric oxide	glyceraldehyde-3-phosphate dehydrogenase	MESH:D009569	2597	Chemical	Gene	target|nmod|START_ENTITY END_ENTITY|nmod|target	Protein thiol modification of glyceraldehyde-3-phosphate_dehydrogenase as a target for nitric_oxide signaling .
9593826	0	nitric_oxide	8,20	gonadotropin-releasing_hormone	42,72	nitric oxide	gonadotropin-releasing hormone	MESH:D009569	25194(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|regulation regulation|nmod|expression expression|amod|END_ENTITY	Role of nitric_oxide in the regulation of gonadotropin-releasing_hormone and tyrosine_hydroxylase gene expression in the male rat brain .
16008888	0	nitric_oxide	67,79	gonadotropin_releasing_hormone	15,45	nitric oxide	gonadotropin releasing hormone	MESH:D009569	2796	Chemical	Gene	treatment|nmod|START_ENTITY treatment|amod|END_ENTITY	-LSB- Influences of gonadotropin_releasing_hormone agonist treatment on nitric_oxide synthase expression in women with endometriosis and infertility -RSB- .
11085902	0	nitric_oxide	147,159	gp120	41,46	nitric oxide	gp120	MESH:D009569	155971(Tax:11676)	Chemical	Gene	involvement|nmod|START_ENTITY effect|dep|involvement effect|nmod|END_ENTITY	Stimulating effect of HIV-1 coat protein gp120 on corticotropin-releasing_hormone and arginine_vasopressin in the rat hypothalamus : involvement of nitric_oxide .
21114628	0	nitric_oxide	103,115	granulocyte-colony_stimulating_factor	51,88	nitric oxide	granulocyte-colony stimulating factor	MESH:D009569	1440	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Rapamycin inhibits lipopolysaccharide induction of granulocyte-colony_stimulating_factor and inducible nitric_oxide synthase expression in macrophages by reducing the levels of octamer-binding_factor-2 .
10207510	0	nitric_oxide	84,96	growth_hormone	19,33	nitric oxide	growth hormone	MESH:D009569	2688	Chemical	Gene	N-monomethyl-L-arginine|amod|START_ENTITY co-infusion|nmod|N-monomethyl-L-arginine influenced|nmod|co-infusion influenced|nsubjpass|secretion secretion|compound|END_ENTITY	L-arginine-induced growth_hormone secretion is not influenced by co-infusion of the nitric_oxide synthase inhibitor N-monomethyl-L-arginine in healthy men .
10442577	0	nitric_oxide	12,24	growth_hormone	50,64	nitric oxide	growth hormone	MESH:D009569	2688	Chemical	Gene	role|nmod|START_ENTITY role|nmod|release release|compound|END_ENTITY	The role of nitric_oxide in L-arginine-stimulated growth_hormone release .
10728365	0	nitric_oxide	8,20	growth_hormone	68,82	nitric oxide	growth hormone	MESH:D009569	2688	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of nitric_oxide in the vasodilator effect of recombinant human growth_hormone in patients with dilated_cardiomyopathy .
11598377	0	nitric_oxide	15,27	growth_hormone	49,63	nitric oxide	growth hormone	MESH:D009569	403795(Tax:9615)	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|regulation regulation|nmod|secretion secretion|amod|END_ENTITY	Involvement of nitric_oxide in the regulation of growth_hormone secretion in dogs .
12507775	0	nitric_oxide	18,30	growth_hormone	68,82	nitric oxide	growth hormone	MESH:D009569	2688	Chemical	Gene	overexpressing|amod|START_ENTITY production|nmod|overexpressing END_ENTITY|nsubj|production	The production of nitric_oxide in EL4_lymphoma cells overexpressing growth_hormone .
18094013	0	nitric_oxide	36,48	growth_hormone	10,24	nitric oxide	growth hormone	MESH:D009569	2688	Chemical	Gene	formation|amod|START_ENTITY Effect|nmod|formation Effect|nmod|therapy therapy|amod|END_ENTITY	Effect of growth_hormone therapy on nitric_oxide formation in cystic_fibrosis patients .
7489334	0	nitric_oxide	8,20	growth_hormone	35,49	nitric oxide	growth hormone	MESH:D009569	81668(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|release release|amod|END_ENTITY	Role of nitric_oxide in control of growth_hormone release in the rat .
9202399	0	nitric_oxide	15,27	growth_hormone	74,88	nitric oxide	growth hormone	MESH:D009569	2688	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|inhibition inhibition|nmod|secretion secretion|compound|END_ENTITY	Involvement of nitric_oxide in the interferon-gamma-induced inhibition of growth_hormone and prolactin secretion in anterior pituitary cell cultures .
11454666	0	nitric_oxide	45,57	haem_oxygenase-1	14,30	nitric oxide	haem oxygenase-1	MESH:D009569	3162	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|expression expression|amod|END_ENTITY	Modulation of haem_oxygenase-1 expression by nitric_oxide and leukotrienes in zymosan-activated macrophages .
12644828	0	nitric_oxide	52,64	haem_oxygenase-1	24,40	nitric oxide	haem oxygenase-1	MESH:D009569	24451(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|effect effect|nmod|END_ENTITY	Antiapoptotic effect of haem_oxygenase-1 induced by nitric_oxide in experimental solid_tumour .
12088854	0	nitric_oxide	19,31	haptoglobin	50,61	nitric oxide	haptoglobin	MESH:D009569	3240	Chemical	Gene	levels|amod|START_ENTITY levels|nmod|END_ENTITY	Elevated levels of nitric_oxide and low levels of haptoglobin are associated with severe malarial_anaemia in African children .
18364244	0	nitric_oxide	8,20	haptoglobin	55,66	nitric oxide	haptoglobin	MESH:D009569	15439(Tax:10090)	Chemical	Gene	Rate|nmod|START_ENTITY bound|nsubj|Rate bound|nmod|END_ENTITY	Rate of nitric_oxide scavenging by hemoglobin bound to haptoglobin .
26467650	0	nitric_oxide	60,72	heat_shock_factor_1	27,46	nitric oxide	heat shock factor 1	MESH:D009569	15499(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Requirement Requirement|nmod|END_ENTITY	Requirement for endogenous heat_shock_factor_1 in inducible nitric_oxide synthase induction in murine microglia .
16981459	0	nitric_oxide	82,94	heat_shock_protein	62,80	nitric oxide	heat shock protein	MESH:D009569	290549(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY synthase|amod|END_ENTITY	-LSB- Effects of Cinnabar and Realgar in Angong Niuhuang powder on heat_shock_protein , nitric_oxide synthase and inflammatory cytokines in contusion cerebral_edema -RSB- .
23419754	0	nitric_oxide	51,63	heat_shock_protein_70	15,36	nitric oxide	heat shock protein 70	MESH:D009569	15511(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Requirement Requirement|nmod|END_ENTITY	Requirement of heat_shock_protein_70 for inducible nitric_oxide synthase induction .
12186546	0	nitric_oxide	50,62	heat_shock_protein_90	75,96	nitric oxide	heat shock protein 90	MESH:D009569	299331(Tax:10116)	Chemical	Gene	synthase|compound|START_ENTITY synthase|nmod|END_ENTITY	Inhibition of superoxide generation from neuronal nitric_oxide synthase by heat_shock_protein_90 : implications in NOS regulation .
16272887	0	nitric_oxide	76,88	hedgehog_interacting_protein	12,40	nitric oxide	hedgehog interacting protein	MESH:D009569	15245(Tax:10090)	Chemical	Gene	cells|amod|START_ENTITY Analysis|nmod|cells Analysis|nmod|END_ENTITY	Analysis of hedgehog_interacting_protein in the brain and its expression in nitric_oxide synthase-positive cells .
10423162	0	nitric_oxide	86,98	heme_oxygenase-1	13,29	nitric oxide	heme oxygenase-1	MESH:D009569	3162	Chemical	Gene	donors|compound|START_ENTITY evoked|nmod|donors evoked|nsubj|Induction Induction|nmod|END_ENTITY	Induction of heme_oxygenase-1 as a response in sensing the signals evoked by distinct nitric_oxide donors .
11283857	0	nitric_oxide	10,22	heme_oxygenase-1	48,64	nitric oxide	heme oxygenase-1	MESH:D009569	24451(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of nitric_oxide on shock-induced hepatic heme_oxygenase-1 expression in the rat .
12230873	0	nitric_oxide	58,70	heme_oxygenase-1	14,30	nitric oxide	heme oxygenase-1	MESH:D009569	3162	Chemical	Gene	involving|dobj|START_ENTITY signals|xcomp|involving signals|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of heme_oxygenase-1 by redox signals involving nitric_oxide .
12433915	0	nitric_oxide	15,27	heme_oxygenase-1	39,55	nitric oxide	heme oxygenase-1	MESH:D009569	3162	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of nitric_oxide with human heme_oxygenase-1 .
14563492	0	nitric_oxide	41,53	heme_oxygenase-1	112,128	nitric oxide	heme oxygenase-1	MESH:D009569	15368(Tax:10090)	Chemical	Gene	production|compound|START_ENTITY Inhibition|nmod|production involves|nsubj|Inhibition involves|xcomp|END_ENTITY	Inhibition of lipopolysaccharide-induced nitric_oxide production by flavonoids in RAW264 .7 macrophages involves heme_oxygenase-1 .
15213303	0	nitric_oxide	80,92	heme_oxygenase-1	9,25	nitric oxide	heme oxygenase-1	MESH:D009569	3162	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nmod|effects	Roles of heme_oxygenase-1 in the antiproliferative and antiapoptotic effects of nitric_oxide on Jurkat T cells .
15220209	0	nitric_oxide	24,36	heme_oxygenase-1	131,147	nitric oxide	heme oxygenase-1	MESH:D009569	15368(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY inducible|dep|expression cells|amod|inducible Regulation|nmod|cells Regulation|dep|role role|nmod|nitric_oxide nitric_oxide|amod|END_ENTITY	Regulation of inducible nitric_oxide synthase expression in advanced glycation end product-stimulated raw 264.7 cells : the role of heme_oxygenase-1 and endogenous nitric_oxide .
15249210	0	nitric_oxide	122,134	heme_oxygenase-1	168,184	nitric oxide	heme oxygenase-1	MESH:D009569	15368(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY suppresses|dobj|expression suppresses|advcl|enhancing enhancing|dobj|expression expression|amod|END_ENTITY	3-Hydroxyanthranilic_acid , one of metabolites of tryptophan via indoleamine_2 ,3 - dioxygenase pathway , suppresses inducible nitric_oxide synthase expression by enhancing heme_oxygenase-1 expression .
15522193	0	nitric_oxide	35,47	heme_oxygenase-1	15,31	nitric oxide	heme oxygenase-1	MESH:D009569	15368(Tax:10090)	Chemical	Gene	resistance|amod|START_ENTITY END_ENTITY|nmod|resistance	A key role for heme_oxygenase-1 in nitric_oxide resistance in murine motor neurons and glia .
15993853	0	nitric_oxide	113,125	heme_oxygenase-1	24,40	nitric oxide	heme oxygenase-1	MESH:D009569	3162	Chemical	Gene	astrocytes|nmod|START_ENTITY protects|dobj|astrocytes protects|nsubj|induction induction|nmod|dismutase dismutase|amod|END_ENTITY	Sequential induction of heme_oxygenase-1 and manganese_superoxide dismutase protects cultured astrocytes against nitric_oxide .
16389572	0	nitric_oxide	68,80	heme_oxygenase-1	126,142	nitric oxide	heme oxygenase-1	MESH:D009569	15368(Tax:10090)	Chemical	Gene	production|compound|START_ENTITY roflumilast|nmod|production effects|nmod|roflumilast mediated|nsubjpass|effects mediated|nmod|END_ENTITY	The inhibitory effects of roflumilast on lipopolysaccharide-induced nitric_oxide production in RAW264 .7 cells are mediated by heme_oxygenase-1 and its product carbon_monoxide .
16781459	0	nitric_oxide	26,38	heme_oxygenase-1	80,96	nitric oxide	heme oxygenase-1	MESH:D009569	3162	Chemical	Gene	production|amod|START_ENTITY production|nmod|expression expression|amod|END_ENTITY	Hydrogen_sulfide inhibits nitric_oxide production and nuclear factor-kappaB via heme_oxygenase-1 expression in RAW264 .7 macrophages stimulated with lipopolysaccharide .
18325727	0	nitric_oxide	135,147	heme_oxygenase-1	33,49	nitric oxide	heme oxygenase-1	MESH:D009569	15368(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY curcumin|nmod|expression effect|nmod|curcumin END_ENTITY|nmod|effect	Involvement of anti-inflammatory heme_oxygenase-1 in the inhibitory effect of curcumin on the expression of pro-inflammatory inducible nitric_oxide synthase in RAW264 .7 macrophages .
19174156	0	nitric_oxide	87,99	heme_oxygenase-1	140,156	nitric oxide	heme oxygenase-1	MESH:D009569	3162	Chemical	Gene	production|compound|START_ENTITY production|nmod|induction induction|amod|END_ENTITY	KB-34 , a newly synthesized chalcone derivative , inhibits lipopolysaccharide-stimulated nitric_oxide production in RAW 264.7 macrophages via heme_oxygenase-1 induction and blockade of activator_protein-1 .
19183880	0	nitric_oxide	82,94	heme_oxygenase-1	154,170	nitric oxide	heme oxygenase-1	MESH:D009569	15368(Tax:10090)	Chemical	Gene	production|compound|START_ENTITY production|nmod|RAW RAW|dep|involvement involvement|nmod|induction induction|amod|END_ENTITY	YL-I-108 , a synthetic chalcone derivative , inhibits lipopolysaccharide-stimulated nitric_oxide production in RAW 264.7 murine macrophages : involvement of heme_oxygenase-1 induction and blockade of activator_protein-1 .
19961388	0	nitric_oxide	103,115	heme_oxygenase-1	30,46	nitric oxide	heme oxygenase-1	MESH:D009569	3162	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	The anti-inflammatory role of heme_oxygenase-1 in lipopolysaccharide and cytokine-stimulated inducible nitric_oxide synthase and nitric_oxide production in human periodontal ligament cells .
20030328	0	nitric_oxide	51,63	heme_oxygenase-1	112,128	nitric oxide	heme oxygenase-1	MESH:D009569	3162	Chemical	Gene	production|compound|START_ENTITY inhibits|dobj|production inhibits|nmod|induction induction|amod|END_ENTITY	Isoegomaketone inhibits lipopolysaccharide-induced nitric_oxide production in RAW 264.7 macrophages through the heme_oxygenase-1 induction and inhibition of the interferon-beta-STAT-1 pathway .
20656003	0	nitric_oxide	138,150	heme_oxygenase-1	15,31	nitric oxide	heme oxygenase-1	MESH:D009569	3162	Chemical	Gene	expression|nmod|START_ENTITY extracts|nmod|expression extracts|amod|END_ENTITY	Involvement of heme_oxygenase-1 in the anti-inflammatory activity of Chrysanthemum boreale Makino extracts on the expression of inducible nitric_oxide synthase in RAW264 .7 macrophages .
20888885	0	nitric_oxide	66,78	heme_oxygenase-1	180,196	nitric oxide	heme oxygenase-1	MESH:D009569	15368(Tax:10090)	Chemical	Gene	production|compound|START_ENTITY raloxifene|nmod|production effect|nmod|raloxifene mediated|nsubjpass|effect mediated|nmod|up-regulation up-regulation|nmod|independent independent|amod|END_ENTITY	The inhibitory effect of raloxifene on lipopolysaccharide-induced nitric_oxide production in RAW264 .7 cells is mediated through a ROS/p38 _ MAPK/CREB pathway to the up-regulation of heme_oxygenase-1 independent of estrogen receptor .
21752327	0	nitric_oxide	46,58	heme_oxygenase-1	15,31	nitric oxide	heme oxygenase-1	MESH:D009569	24451(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY synthase|amod|END_ENTITY	-LSB- Expression of heme_oxygenase-1 and inducible nitric_oxide synthase in the lungs of hyperoxia-exposed preterm rats -RSB- .
21975817	0	nitric_oxide	109,121	heme_oxygenase-1	15,31	nitric oxide	heme oxygenase-1	MESH:D009569	3162	Chemical	Gene	production|amod|START_ENTITY Rhois|nmod|production isolated|nmod|Rhois isolated|nsubj|Involvement Involvement|nmod|induction induction|amod|END_ENTITY	Involvement of heme_oxygenase-1 induction in inhibitory effect of ethyl_gallate isolated from Galla Rhois on nitric_oxide production in RAW 264.7 macrophages .
21975817	0	nitric_oxide	109,121	heme_oxygenase-1	15,31	nitric oxide	heme oxygenase-1	MESH:D009569	3162	Chemical	Gene	production|amod|START_ENTITY Rhois|nmod|production isolated|nmod|Rhois isolated|nsubj|Involvement Involvement|nmod|induction induction|amod|END_ENTITY	Involvement of heme_oxygenase-1 induction in inhibitory effect of ethyl_gallate isolated from Galla Rhois on nitric_oxide production in RAW 264.7 macrophages .
22247601	0	nitric_oxide	83,95	heme_oxygenase-1	120,136	nitric oxide	heme oxygenase-1	MESH:D009569	3162	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|induction induction|amod|END_ENTITY	Okanin , a chalcone found in the genus Bidens , and 3-penten-2-one inhibit inducible nitric_oxide synthase expression via heme_oxygenase-1 induction in RAW264 .7 macrophages activated with lipopolysaccharide .
23261362	0	nitric_oxide	81,93	heme_oxygenase-1	181,197	nitric oxide	heme oxygenase-1	MESH:D009569	24451(Tax:10116)	Chemical	Gene	synthase|compound|START_ENTITY synthase|nmod|macrophages macrophages|nmod|up-regulation up-regulation|nmod|expression expression|amod|END_ENTITY	CHP1002 , a novel andrographolide derivative , inhibits pro-inflammatory inducible nitric_oxide synthase and cyclooxygenase-2 expressions in RAW264 .7 macrophages via up-regulation of heme_oxygenase-1 expression .
23717538	0	nitric_oxide	8,20	heme_oxygenase-1	110,126	nitric oxide	heme oxygenase-1	MESH:D009569	15368(Tax:10090)	Chemical	Gene	protein|compound|START_ENTITY Role|nmod|protein transcription|nsubj|Role transcription|nmod|induction induction|nmod|macrophages macrophages|amod|END_ENTITY	Role of nitric_oxide and CCAAT/enhancer-binding protein transcription factor in statin-dependent induction of heme_oxygenase-1 in mouse macrophages .
25605059	0	nitric_oxide	25,37	heme_oxygenase-1	94,110	nitric oxide	heme oxygenase-1	MESH:D009569	15368(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY suppression|nmod|production Effective|dobj|suppression Effective|nmod|control control|nmod|END_ENTITY	Effective suppression of nitric_oxide production by HX106N through transcriptional control of heme_oxygenase-1 .
25815690	0	nitric_oxide	128,140	heme_oxygenase-1	195,211	nitric oxide	heme oxygenase-1	MESH:D009569	3162	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Resveratrol analog piceatannol restores the palmitic_acid-induced impairment_of_insulin signaling and production of endothelial nitric_oxide via activation of anti-inflammatory and antioxidative heme_oxygenase-1 in human endothelial cells .
26852687	0	nitric_oxide	77,89	heme_oxygenase-1	111,127	nitric oxide	heme oxygenase-1	MESH:D009569	15368(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY suppresses|dobj|synthase suppresses|advcl|inducing inducing|xcomp|END_ENTITY	Amomum tsao-ko fruit extract suppresses lipopolysaccharide-induced inducible nitric_oxide synthase by inducing heme_oxygenase-1 in macrophages and in septic mice .
8764571	0	nitric_oxide	99,111	heme_oxygenase-1	79,95	nitric oxide	heme oxygenase-1	MESH:D009569	3162	Chemical	Gene	donors|amod|START_ENTITY oxygenase|nmod|donors oxygenase|nmod|brain brain|nmod|END_ENTITY	Expression of heme oxygenase isozyme mRNAs in the human brain and induction of heme_oxygenase-1 by nitric_oxide donors .
8769112	0	nitric_oxide	19,31	heme_oxygenase-1	73,89	nitric oxide	heme oxygenase-1	MESH:D009569	24451(Tax:10116)	Chemical	Gene	SIN-1|amod|START_ENTITY precursor|nmod|SIN-1 modulates|nsubj|precursor modulates|xcomp|END_ENTITY	A precursor of the nitric_oxide donor SIN-1 modulates the stress protein heme_oxygenase-1 in rat liver .
9374724	0	nitric_oxide	82,94	heme_oxygenase-1	14,30	nitric oxide	heme oxygenase-1	MESH:D009569	3162	Chemical	Gene	smooth|nmod|START_ENTITY smooth|nsubj|Regulation Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of heme_oxygenase-1 gene expression in vascular smooth muscle cells by nitric_oxide .
10491133	0	nitric_oxide	37,49	heme_oxygenase-2	15,31	nitric oxide	heme oxygenase-2	MESH:D009569	3163	Chemical	Gene	donors|amod|START_ENTITY Interaction|nmod|donors Interaction|nmod|END_ENTITY	Interaction of heme_oxygenase-2 with nitric_oxide donors .
10910101	0	nitric_oxide	89,101	heme_oxygenase-2	16,32	nitric oxide	heme oxygenase-2	MESH:D009569	79239(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Localization Localization|nmod|END_ENTITY	Localization of heme_oxygenase-2 and modulation of cGMP levels by carbon_monoxide and/or nitric_oxide in the retina .
23760291	0	nitric_oxide	4,16	heparin_binding_EGF-like_growth_factor	51,89	nitric oxide	heparin binding EGF-like growth factor	MESH:D009569	15200(Tax:10090)	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Low nitric_oxide bioavailability upregulates renal heparin_binding_EGF-like_growth_factor expression .
10607702	0	nitric_oxide	117,129	hypoxia-inducible_factor-1	142,168	nitric oxide	hypoxia-inducible factor-1	MESH:D009569	3091	Chemical	Gene	mediates|nmod|START_ENTITY mediates|parataxis|control control|nmod|activity activity|amod|END_ENTITY	Hypoxia response element of the human vascular_endothelial_growth_factor gene mediates transcriptional regulation by nitric_oxide : control of hypoxia-inducible_factor-1 activity by nitric_oxide .
10607702	0	nitric_oxide	181,193	hypoxia-inducible_factor-1	142,168	nitric oxide	hypoxia-inducible factor-1	MESH:D009569	3091	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Hypoxia response element of the human vascular_endothelial_growth_factor gene mediates transcriptional regulation by nitric_oxide : control of hypoxia-inducible_factor-1 activity by nitric_oxide .
15165103	0	nitric_oxide	68,80	hypoxia-inducible_factor-1alpha	28,59	nitric oxide	hypoxia-inducible factor-1alpha	MESH:D009569	29560(Tax:10116)	Chemical	Gene	mRNA|nmod|START_ENTITY mRNA|amod|END_ENTITY	Inhibition of expression of hypoxia-inducible_factor-1alpha mRNA by nitric_oxide in hypoxic_pulmonary_hypertension rats .
25881609	0	nitric_oxide	48,60	hypoxia-inducible_factor-2a	71,98	nitric oxide	hypoxia-inducible factor-2a	MESH:D009569	2034	Chemical	Gene	vascular_endothelial_growth_factor|compound|START_ENTITY vascular_endothelial_growth_factor|amod|END_ENTITY	Tongxinluo inhibits cyclooxygenase-2 , inducible nitric_oxide synthase , hypoxia-inducible_factor-2a / vascular_endothelial_growth_factor to antagonize injury in hypoxia-stimulated cardiac microvascular endothelial cells .
15901372	1	nitric_oxide	71,83	hypoxia-inducible_factor_1	33,59	nitric oxide	hypoxia-inducible factor 1	MESH:D009569	3091	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of hypoxia-inducible_factor_1 -LRB- HIF-1 -RRB- by nitric_oxide in oral_squamous_cell_carcinoma .
9636155	0	nitric_oxide	53,65	hypoxia-inducible_factor_1	14,40	nitric oxide	hypoxia-inducible factor 1	MESH:D009569	3091	Chemical	Gene	donors|amod|START_ENTITY Inhibition|nmod|donors Inhibition|nmod|activity activity|amod|END_ENTITY	Inhibition of hypoxia-inducible_factor_1 activity by nitric_oxide donors in hypoxia .
12678687	0	nitric_oxide	12,24	hypoxia_inducible_factor-1alpha	57,88	nitric oxide	hypoxia inducible factor-1alpha	MESH:D009569	3091	Chemical	Gene	role|nmod|START_ENTITY role|nmod|regulation regulation|nmod|END_ENTITY	The role of nitric_oxide -LRB- NO -RRB- in stability regulation of hypoxia_inducible_factor-1alpha -LRB- HIF-1alpha -RRB- .
10337059	0	nitric_oxide	47,59	i-NOS	114,119	nitric oxide	i-NOS	MESH:D009569	24599(Tax:10116)	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Immunocytochemical localization of endothelial nitric_oxide synthase -LRB- e-NOS -RRB- and inducible nitric_oxide synthase -LRB- i-NOS -RRB- in rat neurohypophysis after transient cerebral_ischemia .
10962132	0	nitric_oxide	89,101	i-NOS	112,117	nitric oxide	i-NOS	MESH:D009569	4843	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	Nitrosative stress in primary glial_cultures after induction of the inducible isoform of nitric_oxide synthase -LRB- i-NOS -RRB- .
10071960	0	nitric_oxide	51,63	iNOS	65,69	nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	START_ENTITY|ccomp|mRNA mRNA|nsubj|END_ENTITY	Inhibition of lipopolysaccharide-induced inducible nitric_oxide -LRB- iNOS -RRB- mRNA expression and nitric_oxide production by higenamine in murine peritoneal macrophages .
10102685	1	nitric_oxide	183,195	iNOS	206,210	nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	Nitric_oxide -LRB- NO -RRB- , synthesized by the inducible isoform of nitric_oxide synthase -LRB- iNOS -RRB- , has been proposed as a mediator of immune-induced beta-cell destruction in type 1 diabetes .
10357916	0	nitric_oxide	31,43	iNOS	54,58	nitric oxide	iNOS	MESH:D009569	24599(Tax:10116)	Chemical	Gene	synthase|advmod|START_ENTITY synthase|ccomp|render render|nsubj|END_ENTITY	Does upregulation of inducible nitric_oxide synthase -LRB- iNOS -RRB- render the stomach more susceptible to damage ?
10374875	0	nitric_oxide	23,35	iNOS	46,50	nitric oxide	iNOS	MESH:D009569	4843	Chemical	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Detection of inducible nitric_oxide synthase -LRB- iNOS -RRB- mRNA by RT-PCR in ATL patients and HTLV-I infected cell lines : clinical features and apoptosis by NOS inhibitor .
10395902	0	nitric_oxide	60,72	iNOS	83,87	nitric oxide	iNOS	MESH:D009569	24599(Tax:10116)	Chemical	Gene	gene|amod|START_ENTITY gene|dep|END_ENTITY	Molecular cloning and characterization of the rat inducible nitric_oxide synthase -LRB- iNOS -RRB- gene .
10416126	1	nitric_oxide	223,235	iNOS	338,342	nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	synthesis|amod|START_ENTITY synthesis|amod|due due|nmod|competition competition|nmod|synthase synthase|appos|END_ENTITY	The hypothesis was tested that induction of arginase expression in macrophages -LRB- M phi -RRB- diminishes nitric_oxide -LRB- NO -RRB- synthesis due to intracellular competition between arginase and inducible nitric_oxide synthase -LRB- iNOS -RRB- for L-arginine -LRB- L-arg -RRB- .
10416126	1	nitric_oxide	315,327	iNOS	338,342	nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	The hypothesis was tested that induction of arginase expression in macrophages -LRB- M phi -RRB- diminishes nitric_oxide -LRB- NO -RRB- synthesis due to intracellular competition between arginase and inducible nitric_oxide synthase -LRB- iNOS -RRB- for L-arginine -LRB- L-arg -RRB- .
10450786	0	nitric_oxide	77,89	iNOS	100,104	nitric oxide	iNOS	MESH:D009569	4843	Chemical	Gene	synthase|compound|START_ENTITY -2|appos|synthase -1|dep|-2 -1|appos|END_ENTITY	The analgesic NSAID lornoxicam inhibits cyclooxygenase _ -LRB- COX -RRB- -1 / -2 , inducible nitric_oxide synthase -LRB- iNOS -RRB- , and the formation of interleukin -LRB- IL -RRB- -6 in vitro .
10737225	0	nitric_oxide	104,116	iNOS	35,39	nitric oxide	iNOS	MESH:D009569	282876(Tax:9913)	Chemical	Gene	production|amod|START_ENTITY relationship|nmod|production END_ENTITY|dep|relationship	Vitamin_K2 -LRB- menatetrenone -RRB- induces iNOS in bovine vascular smooth muscle cells : no relationship between nitric_oxide production and gamma-carboxylation .
10780958	0	nitric_oxide	39,51	iNOS	62,66	nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|expression expression|appos|END_ENTITY	Mechanisms of suppression of inducible nitric_oxide synthase -LRB- iNOS -RRB- expression in RAW 264.7 cells by andrographolide .
10807016	0	nitric_oxide	72,84	iNOS	113,117	nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	involve|dobj|START_ENTITY involve|parataxis|using using|ccomp|knock knock|nsubj|END_ENTITY	Endotoxin-induced mesenteric microvascular changes involve iNOS-derived nitric_oxide : results from a study using iNOS knock out mice .
10811015	0	nitric_oxide	43,55	iNOS	66,70	nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Ceramide-mediated stimulation of inducible nitric_oxide synthase -LRB- iNOS -RRB- and tumor_necrosis_factor -LRB- TNF -RRB- accumulation in murine macrophages requires tyrosine kinase activity .
10842159	0	nitric_oxide	10,22	iNOS	33,37	nitric oxide	iNOS	MESH:D009569	24599(Tax:10116)	Chemical	Gene	upregulates|amod|START_ENTITY upregulates|appos|END_ENTITY	Inducible nitric_oxide synthase -LRB- iNOS -RRB- expression upregulates p21 and inhibits vascular smooth muscle cell proliferation through p42/44 mitogen-activated protein kinase activation and independent of p53 and cyclic_guanosine_monophosphate .
10847627	0	nitric_oxide	44,56	iNOS	67,71	nitric oxide	iNOS	MESH:D009569	4843	Chemical	Gene	regulation|nmod|START_ENTITY synthase|nsubj|regulation synthase|xcomp|gene gene|dep|END_ENTITY	Molecular regulation of the human inducible nitric_oxide synthase -LRB- iNOS -RRB- gene .
10909967	0	nitric_oxide	93,105	iNOS	116,120	nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	synthase|amod|START_ENTITY isoform|nmod|synthase lacking|dobj|isoform mice|acl|lacking mice|dep|END_ENTITY	Cytokines induce apoptosis in beta-cells isolated from mice lacking the inducible isoform of nitric_oxide synthase -LRB- iNOS - / - -RRB- .
10912885	0	nitric_oxide	28,40	iNOS	51,55	nitric oxide	iNOS	MESH:D009569	4843	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	Expression of the inducible nitric_oxide synthase -LRB- iNOS -RRB- in human leukocytes : responses to running exercise .
10964656	0	nitric_oxide	90,102	iNOS	113,117	nitric oxide	iNOS	MESH:D009569	24599(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|gene gene|appos|END_ENTITY	Involvement of nuclear factor-kappaB -LRB- NF-kappaB -RRB- signaling in the expression of inducible nitric_oxide synthase -LRB- iNOS -RRB- gene in rat C6 glioma cells .
10975910	0	nitric_oxide	36,48	iNOS	59,63	nitric oxide	iNOS	MESH:D009569	24599(Tax:10116)	Chemical	Gene	upregulation|nmod|START_ENTITY synthase|nsubj|upregulation synthase|dobj|END_ENTITY	Selective upregulation of inducible nitric_oxide synthase -LRB- iNOS -RRB- by lipopolysaccharide -LRB- LPS -RRB- and cytokines in microglia : in vitro and in vivo studies .
11006448	0	nitric_oxide	24,36	iNOS	47,51	nitric oxide	iNOS	MESH:D009569	24599(Tax:10116)	Chemical	Gene	Expression|nmod|START_ENTITY synthase|nsubj|Expression synthase|dobj|END_ENTITY	Expression of inducible nitric_oxide synthase -LRB- iNOS -RRB- in middle_ear_epithelial_cells by IL-1beta and TNF-alpha .
11167996	0	nitric_oxide	32,44	iNOS	55,59	nitric oxide	iNOS	MESH:D009569	4843	Chemical	Gene	START_ENTITY|dobj|production production|appos|END_ENTITY	Effect of adhesion on inducible nitric_oxide synthase -LRB- iNOS -RRB- production in purified human neutrophils .
11304846	0	nitric_oxide	42,54	iNOS	65,69	nitric oxide	iNOS	MESH:D009569	4843	Chemical	Gene	expression|nmod|START_ENTITY synthase|nsubj|expression synthase|dobj|END_ENTITY	The physiological expression of inducible nitric_oxide synthase -LRB- iNOS -RRB- in the human colon .
11566631	0	nitric_oxide	41,53	iNOS	65,69	nitric oxide	iNOS	MESH:D009569	24599(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Strain-dependent difference in inducible nitric_oxide synthesis -LRB- iNOS -RRB- expression in rat pancreatic islets correlates with interferon_regulating_factor_1 -LRB- IRF-1 -RRB- and heat_shock_protein_70 -LRB- HSP70 -RRB- expression .
11597171	0	nitric_oxide	18,30	iNOS	102,106	nitric oxide	iNOS	MESH:D009569	51477	Chemical	Gene	production|amod|START_ENTITY Regulation|nmod|production Regulation|acl|resulting resulting|nmod|expression expression|nmod|END_ENTITY	Regulation of the nitric_oxide production resulting from the glucocorticoid-insensitive expression of iNOS in human osteoarthritic cartilage .
11715524	0	nitric_oxide	11,23	iNOS	138,142	nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	synthase|amod|START_ENTITY Effect|nmod|synthase inhibitor|nsubj|Effect inhibitor|nmod|cells cells|acl|expressing expressing|dobj|-RSB- -RSB-|amod|END_ENTITY	-LSB- Effect of nitric_oxide synthase inhibitor on signal transduction pathway of opiate tolerance and dependence in NG108-15 cells expressing iNOS gene -RSB- .
11831438	0	nitric_oxide	55,67	iNOS	78,82	nitric oxide	iNOS	MESH:D009569	24599(Tax:10116)	Chemical	Gene	atRA|nmod|START_ENTITY Effects|nmod|atRA synthase|nsubj|Effects synthase|xcomp|activity activity|dep|END_ENTITY	Effects of all-trans-retinoic_acid -LRB- atRA -RRB- on inducible nitric_oxide synthase -LRB- iNOS -RRB- activity and transforming growth factor beta-1 production in experimental anti-GBM antibody-mediated glomerulonephritis .
11876895	0	nitric_oxide	52,64	iNOS	75,79	nitric oxide	iNOS	MESH:D009569	100008833(Tax:9986)	Chemical	Gene	expression|nmod|START_ENTITY Study|nmod|expression synthase|nsubj|Study synthase|dobj|END_ENTITY	-LSB- Study on the abnormal gene expression of inducible nitric_oxide synthase -LRB- iNOS -RRB- in rabbit myocardium after high voltage electrical_injury -RSB- .
12086400	0	nitric_oxide	87,99	iNOS	110,114	nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|activity activity|appos|END_ENTITY	Suppressive effect of natural sesquiterpenoids on inducible cyclooxygenase -LRB- COX-2 -RRB- and nitric_oxide synthase -LRB- iNOS -RRB- activity in mouse macrophage cells .
12240898	0	nitric_oxide	25,37	iNOS	48,52	nitric oxide	iNOS	MESH:D009569	4843	Chemical	Gene	synthase|nsubj|START_ENTITY synthase|dobj|END_ENTITY	Nitrotyrosine , inducible nitric_oxide synthase -LRB- iNOS -RRB- , and endothelial_nitric_oxide_synthase -LRB- eNOS -RRB- are increased in thyroid_tumors from children and adolescents .
12406306	0	nitric_oxide	42,54	iNOS	65,69	nitric oxide	iNOS	MESH:D009569	4843	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Immunohistochemical analysis of inducible nitric_oxide synthase -LRB- iNOS -RRB- and heat_shock proteins -LRB- HSPs -RRB- in ameloblastomas .
12594592	0	nitric_oxide	24,36	iNOS	47,51	nitric oxide	iNOS	MESH:D009569	396821(Tax:9823)	Chemical	Gene	Mechanisms|nmod|START_ENTITY synthase|nsubj|Mechanisms synthase|dobj|improvement improvement|appos|END_ENTITY	Mechanisms of inducible nitric_oxide synthase -LRB- iNOS -RRB- inhibition-related improvement of gut mucosal_acidosis during hyperdynamic_porcine_endotoxemia .
12595462	0	nitric_oxide	162,174	iNOS	92,96	nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	induction|nmod|START_ENTITY END_ENTITY|nmod|induction	Role of the NF-kappaB signaling pathway and kappaB cis-regulatory elements on the IRF-1 and iNOS promoter regions in mycobacterial lipoarabinomannan induction of nitric_oxide .
12604012	0	nitric_oxide	88,100	iNOS	20,24	nitric oxide	iNOS	MESH:D009569	4843	Chemical	Gene	involvement|amod|START_ENTITY expression|dep|involvement END_ENTITY|dobj|expression	Morphine stimulates iNOS expression via a rebound from inhibition in human macrophages : nitric_oxide involvement .
12618316	0	nitric_oxide	32,44	iNOS	55,59	nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY synthase|nsubj|expression synthase|dobj|END_ENTITY	Altered expression of inducible nitric_oxide synthase -LRB- iNOS -RRB- in the cochlea .
12624786	0	nitric_oxide	44,56	iNOS	113,117	nitric oxide	iNOS	MESH:D009569	4843	Chemical	Gene	synthase|compound|START_ENTITY expression|nmod|synthase expression|dep|relationships relationships|nmod|proteins proteins|amod|superoxide_dismutase superoxide_dismutase|amod|END_ENTITY	Immunohistochemical expression of inducible nitric_oxide synthase -LRB- iNOS -RRB- in human brain_tumors : relationships of iNOS to superoxide_dismutase -LRB- SOD -RRB- proteins -LRB- SOD1 and SOD2 -RRB- , Ki-67 antigen -LRB- MIB-1 -RRB- and p53 protein .
12624786	0	nitric_oxide	44,56	iNOS	67,71	nitric oxide	iNOS	MESH:D009569	4843	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Immunohistochemical expression of inducible nitric_oxide synthase -LRB- iNOS -RRB- in human brain_tumors : relationships of iNOS to superoxide_dismutase -LRB- SOD -RRB- proteins -LRB- SOD1 and SOD2 -RRB- , Ki-67 antigen -LRB- MIB-1 -RRB- and p53 protein .
12636250	0	nitric_oxide	70,82	iNOS	94,98	nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	The reduction of Fusobacterium_nucleatum in mice is irrelevant to the nitric_oxide induced by iNOS .
12898012	0	nitric_oxide	45,57	iNOS	68,72	nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Suppressive effects of a selective inducible nitric_oxide synthase -LRB- iNOS -RRB- inhibitor on pancreatic beta-cell dysfunction .
14599552	0	nitric_oxide	102,114	iNOS	73,77	nitric oxide	iNOS	MESH:D009569	4843	Chemical	Gene	START_ENTITY|nsubj|deiminase deiminase|nmod|modulator modulator|nmod|END_ENTITY	Recombinant arginine deiminase as a differential modulator of inducible -LRB- iNOS -RRB- and endothelial -LRB- eNOS -RRB- nitric_oxide synthetase activity in cultured endothelial cells .
14611727	0	nitric_oxide	68,80	iNOS	91,95	nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	Novel peptides enhance the production of nitric_oxide and inducible nitric_oxide synthase -LRB- iNOS -RRB- gene expression in murine macrophage .
14611727	5	nitric_oxide	850,862	iNOS	873,877	nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Western blot and PCR analysis also showed that increased production of protein expression and mRNA expression of inducible nitric_oxide synthase -LRB- iNOS -RRB- .
14710909	4	nitric_oxide	681,693	iNOS	704,708	nitric oxide	iNOS	MESH:D009569	4843	Chemical	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	We then examined the influence of RXM on inducible nitric_oxide synthase -LRB- iNOS -RRB- mRNA expression in NPFs .
15051034	4	nitric_oxide	1172,1184	iNOS	1195,1199	nitric oxide	iNOS	MESH:D009569	4843	Chemical	Gene	synthase|amod|START_ENTITY synthase|dep|END_ENTITY	The expression of mRNA for inducible and endothelial constitutive nitric_oxide synthase -LRB- iNOS and ecNOS , respectively -RRB- was assessed by reverse transcriptase polymerase chain reaction .
15138204	0	nitric_oxide	127,139	iNOS	150,154	nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	mice|amod|START_ENTITY mice|appos|END_ENTITY	Gastric_damage and granulocyte infiltration induced by indomethacin in tumour_necrosis_factor_receptor_1 -LRB- TNF-R1 -RRB- or inducible nitric_oxide synthase -LRB- iNOS -RRB- deficient mice .
15170612	0	nitric_oxide	48,60	iNOS	71,75	nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	activity|nmod|START_ENTITY synthase|nsubj|activity synthase|dobj|END_ENTITY	Functional activity and expression of inducible nitric_oxide synthase -LRB- iNOS -RRB- in muscle of the isolated distal colon of mdx mice .
15322268	8	nitric_oxide	1269,1281	iNOS	1401,1405	nitric oxide	iNOS	MESH:D009569	24599(Tax:10116)	Chemical	Gene	START_ENTITY|parataxis|decreased decreased|advcl|potentiated potentiated|nsubj|inhibition inhibition|nmod|inducible_NO_synthase inducible_NO_synthase|appos|END_ENTITY	One such factor could be nitric_oxide -LRB- NO -RRB- ; indeed a NO donor decreased the BSO plus CYP2E1-dependent toxicity , whereas inhibition of inducible_NO_synthase -LRB- iNOS -RRB- potentiated toxicity .
15452455	0	nitric_oxide	23,35	iNOS	84,88	nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY effects|nmod|production synthase|nsubj|effects synthase|xcomp|expression expression|dep|END_ENTITY	Suppressive effects of nitric_oxide production and inducible nitric_oxide synthase -LRB- iNOS -RRB- gene expression by Calystegia soldanella methanol extract on lipopolysaccharide-activated RAW 264.7 cells .
15467252	0	nitric_oxide	102,114	iNOS	125,129	nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	A new lignan from Balanophora abbreviata and inhibition of lipopolysaccharide -LRB- LPS -RRB- - induced inducible nitric_oxide synthase -LRB- iNOS -RRB- expression .
15551374	0	nitric_oxide	32,44	iNOS	55,59	nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|expression expression|appos|END_ENTITY	Suppressive effect of inducible nitric_oxide synthase -LRB- iNOS -RRB- expression by the methanol extract of Actinodaphne lancifolia .
15566969	0	nitric_oxide	25,37	iNOS	109,113	nitric oxide	iNOS	MESH:D009569	4843	Chemical	Gene	Stimulation|nmod|START_ENTITY synthase|nsubj|Stimulation synthase|nmod|crystals crystals|nmod|END_ENTITY	Stimulation of inducible nitric_oxide synthase by monosodium_urate crystals in macrophages and expression of iNOS in gouty_arthritis .
15714114	0	nitric_oxide	40,52	iNOS	63,67	nitric oxide	iNOS	MESH:D009569	4843	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Sunscreen ingredients inhibit inducible nitric_oxide synthase -LRB- iNOS -RRB- : a possible biochemical explanation for the sunscreen melanoma controversy .
15718251	0	nitric_oxide	79,91	iNOS	102,106	nitric oxide	iNOS	MESH:D009569	24599(Tax:10116)	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Differential requirement of signal pathways for benzo -LSB- a -RSB- pyrene -LRB- B -LSB- a -RSB- P -RRB- - induced nitric_oxide synthase -LRB- iNOS -RRB- in rat esophageal epithelial cells .
15880470	0	nitric_oxide	12,24	iNOS	71,75	nitric oxide	iNOS	MESH:D009569	24599(Tax:10116)	Chemical	Gene	S-nitroso-N-acetylcysteine|amod|START_ENTITY S-nitroso-N-acetylcysteine|nmod|inhibitor inhibitor|compound|END_ENTITY	Addition of nitric_oxide donor S-nitroso-N-acetylcysteine to selective iNOS inhibitor 1400W further improves contractile function in reperfused skeletal muscle .
16178293	0	nitric_oxide	26,38	iNOS	49,53	nitric oxide	iNOS	MESH:D009569	4843	Chemical	Gene	START_ENTITY|dobj|expression expression|appos|END_ENTITY	Upregulation of inducible nitric_oxide synthase -LRB- iNOS -RRB- expression in faster-healing_chronic_leg_ulcers .
16201316	0	nitric_oxide	54,66	iNOS	77,81	nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Effect of aminoguanidine and albendazole on inducible nitric_oxide synthase -LRB- iNOS -RRB- activity in T. _ spiralis-infected mice muscles .
16360270	0	nitric_oxide	77,89	iNOS	100,104	nitric oxide	iNOS	MESH:D009569	24599(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	GW274150 , a novel and highly selective inhibitor of the inducible isoform of nitric_oxide synthase -LRB- iNOS -RRB- , shows analgesic effects in rat models of inflammatory and neuropathic_pain .
16378509	0	nitric_oxide	37,49	iNOS	60,64	nitric oxide	iNOS	MESH:D009569	4843	Chemical	Gene	effects|nmod|START_ENTITY synthase|nsubj|effects synthase|dobj|END_ENTITY	The pleiotropic effects of inducible nitric_oxide synthase -LRB- iNOS -RRB- on the physiology and pathology of penile erection .
16565987	0	nitric_oxide	32,44	iNOS	55,59	nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Inverse regulation of inducible nitric_oxide synthase -LRB- iNOS -RRB- and arginase_I by the protein tyrosine phosphatase SHP-1 in CNS glia .
16650388	0	nitric_oxide	119,131	iNOS	142,146	nitric oxide	iNOS	MESH:D009569	4843	Chemical	Gene	blockade|nmod|START_ENTITY contraction|nmod|blockade responses|nmod|contraction synthase|nsubj|responses synthase|dobj|END_ENTITY	Cardiovascular responses and neurotransmitter changes during static muscle contraction following blockade of inducible nitric_oxide synthase -LRB- iNOS -RRB- within the ventrolateral medulla .
17120617	0	nitric_oxide	34,46	iNOS	57,61	nitric oxide	iNOS	MESH:D009569	4843	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Chemotherapy influences inducible nitric_oxide synthase -LRB- iNOS -RRB- and endothelial nitric_oxide synthase -LRB- eNOS -RRB- activity on 3D breast_cancer cell line .
17189827	0	nitric_oxide	67,79	iNOS	90,94	nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Novel role of IL-6 / SIL-6R signaling in the expression of inducible nitric_oxide synthase -LRB- iNOS -RRB- in murine B16 , metastatic melanoma clone F10 .9 , cells .
17395412	0	nitric_oxide	109,121	iNOS	132,136	nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	The anti-inflammatory effects of Pyrolae herba extract through the inhibition of the expression of inducible nitric_oxide synthase -LRB- iNOS -RRB- and NO production .
17418925	0	nitric_oxide	66,78	iNOS	89,93	nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	Suppressive effects of nitric_oxide -LRB- NO -RRB- production and inducible nitric_oxide synthase -LRB- iNOS -RRB- expression by Citrus reticulata extract in RAW 264.7 macrophage cells .
17502692	0	nitric_oxide	28,40	iNOS	51,55	nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	Investigations|nmod|START_ENTITY synthase|nsubj|Investigations synthase|xcomp|expression expression|dep|END_ENTITY	Investigations on inducible nitric_oxide synthase -LRB- iNOS -RRB- gene expression and SEM analysis during the interaction of a novel tissue adhesive with J774A .1 mouse macrophage cells .
17658518	0	nitric_oxide	10,22	iNOS	33,37	nitric oxide	iNOS	MESH:D009569	24599(Tax:10116)	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Inducible nitric_oxide synthase -LRB- iNOS -RRB- mediates the early increase of blood supply -LRB- EIBS -RRB- in colon_carcinogenesis .
17879278	0	nitric_oxide	49,61	iNOS	72,76	nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Early bacterial dependent induction of inducible nitric_oxide synthase -LRB- iNOS -RRB- in epithelial cells upon transfer of CD45RB -LRB- high -RRB- CD4 -LRB- + -RRB- T cells in a model for experimental colitis .
17891158	0	nitric_oxide	27,39	iNOS	64,68	nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY inhibit|dobj|production inhibit|advcl|enhancing enhancing|dobj|degradation degradation|amod|END_ENTITY	PPARalpha agonists inhibit nitric_oxide production by enhancing iNOS degradation in LPS-treated macrophages .
18222473	0	nitric_oxide	23,35	iNOS	46,50	nitric oxide	iNOS	MESH:D009569	24599(Tax:10116)	Chemical	Gene	synthase|nsubj|START_ENTITY synthase|xcomp|peroxidation peroxidation|dep|END_ENTITY	Liver tissue inducible nitric_oxide synthase -LRB- iNOS -RRB- expression and lipid peroxidation in experimental hepatic_ischemia reperfusion injury stimulated with lipopolysaccharide : the role of aminoguanidine .
18391763	0	nitric_oxide	10,22	iNOS	33,37	nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Inducible nitric_oxide synthase -LRB- iNOS -RRB- is not required for IL-2-induced hypotension and vascular_leak_syndrome in mice .
18586326	0	nitric_oxide	8,20	iNOS	118,122	nitric oxide	iNOS	MESH:D009569	395807(Tax:9031)	Chemical	Gene	production|compound|START_ENTITY transfected|nsubj|production transfected|nmod|siRNAs siRNAs|amod|END_ENTITY	Reduced nitric_oxide production and iNOS mRNA expression in IFN-gamma-stimulated chicken macrophages transfected with iNOS siRNAs .
18802679	3	nitric_oxide	545,557	iNOS	568,572	nitric oxide	iNos	MESH:D009569	18126(Tax:10090)	Chemical	Gene	contribution|nmod|START_ENTITY evaluated|dobj|contribution study|acl|evaluated synthase|nsubj|study synthase|dobj|END_ENTITY	This study evaluated the contribution of inducible nitric_oxide synthase -LRB- iNOS -RRB- to peroxynitrite_injury_to_peripheral_nerve and dorsal root ganglia and development of peripheral_diabetic_neuropathy .
18836229	0	nitric_oxide	57,69	iNOS	144,148	nitric oxide	iNOS	MESH:D009569	282876(Tax:9913)	Chemical	Gene	influences|dobj|START_ENTITY influences|nmod|chondrocytes chondrocytes|nmod|alterations alterations|nmod|END_ENTITY	Dynamic compression influences interleukin-1beta-induced nitric_oxide and prostaglandin_E2 release by articular chondrocytes via alterations in iNOS and COX-2 expression .
18836533	0	nitric_oxide	118,130	iNOS	161,165	nitric oxide	iNOS	MESH:D009569	4843	Chemical	Gene	synthases|amod|START_ENTITY synthases|appos|END_ENTITY	The return of the Scarlet Pimpernel : cobalamin in inflammation II - cobalamins can both selectively promote all three nitric_oxide synthases -LRB- NOS -RRB- , particularly iNOS and eNOS , and , as needed , selectively inhibit iNOS and nNOS .
18855521	0	nitric_oxide	143,155	iNOS	111,115	nitric oxide	iNOS	MESH:D009569	24599(Tax:10116)	Chemical	Gene	bioavailability|amod|START_ENTITY enhancement|nmod|bioavailability leading|nmod|enhancement protects|advcl|leading protects|nmod|overexpression overexpression|nmod|END_ENTITY	Sulfaphenazole protects heart against ischemia-reperfusion injury_and_cardiac_dysfunction by overexpression of iNOS , leading to enhancement of nitric_oxide bioavailability and tissue oxygenation .
19298870	0	nitric_oxide	55,67	iNOS	78,82	nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|expression expression|appos|END_ENTITY	Suppression of lipopolysaccharide-stimulated inducible nitric_oxide synthase -LRB- iNOS -RRB- expression by a novel humulene derivative in macrophage cells .
19376148	0	nitric_oxide	101,113	iNOS	145,149	nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY lipoteichoic_acid|dobj|production lipoteichoic_acid|advcl|stimulating stimulating|dobj|ubiquitination ubiquitination|amod|END_ENTITY	Zinc protoporphyrin inhibition of lipopolysaccharide - , lipoteichoic_acid - , and peptidoglycan-induced nitric_oxide production through stimulating iNOS protein ubiquitination .
20169057	0	nitric_oxide	45,57	iNOS	134,138	nitric oxide	iNOS	MESH:D009569	24599(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY occurring|nmod|synthesis occurring|parataxis|END_ENTITY	Cerebral and peripheral changes occurring in nitric_oxide -LRB- NO -RRB- synthesis in a rat model of sleeping_sickness : identification of brain iNOS expressing cells .
20417174	0	nitric_oxide	54,66	iNOS	77,81	nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Quercetin_tetraacetyl derivative inhibits LPS-induced nitric_oxide synthase -LRB- iNOS -RRB- expression in J774A .1 cells .
20430367	0	nitric_oxide	114,126	iNOS	26,30	nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	formation|compound|START_ENTITY affects|dobj|formation affects|nsubj|use use|nmod|END_ENTITY	Systemic use of selective iNOS inhibitor 1400W or non-selective NOS inhibitor l-NAME differently affects systemic nitric_oxide formation after oral Porphyromonas_gingivalis inoculation in mice .
20508290	0	nitric_oxide	25,37	iNOS	55,59	nitric oxide	iNOS	MESH:D009569	24599(Tax:10116)	Chemical	Gene	synthases|amod|START_ENTITY synthases|dep|eNOS eNOS|appos|END_ENTITY	Effect of simvastatin on nitric_oxide synthases -LRB- eNOS , iNOS -RRB- and arginine and its derivatives -LRB- ADMA , SDMA -RRB- in ischemia/reperfusion injury in rat liver .
20626593	0	nitric_oxide	38,50	iNOS	61,65	nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	inactivation|nmod|START_ENTITY synthase|nsubj|inactivation synthase|ccomp|intensifies intensifies|nsubj|END_ENTITY	The genetic inactivation of inducible nitric_oxide synthase -LRB- iNOS -RRB- intensifies fibrosis and oxidative stress in the penile corpora cavernosa in type 1 diabetes .
20955790	0	nitric_oxide	8,20	iNOS	33,37	nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	Role|nmod|START_ENTITY produced|nsubj|Role produced|nmod|END_ENTITY	Role of nitric_oxide produced by iNOS through NF-kB pathway in migration of cerebellar granule neurons induced by Lipopolysaccharide .
21035557	0	nitric_oxide	42,54	iNOS	65,69	nitric oxide	iNOS	MESH:D009569	4843	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	Selenomethionine inhibits IL-1b inducible nitric_oxide synthase -LRB- iNOS -RRB- and cyclooxygenase_2 -LRB- COX2 -RRB- expression in primary human chondrocytes .
21039732	0	nitric_oxide	10,22	iNOS	33,37	nitric oxide	iNOS	MESH:D009569	4843	Chemical	Gene	synthase|nsubj|START_ENTITY synthase|xcomp|polymorphism polymorphism|dep|END_ENTITY	Inducible nitric_oxide synthase -LRB- iNOS -RRB- gene polymorphism and disease prevalence .
21068477	0	nitric_oxide	33,45	iNOS	61,65	nitric oxide	iNOS	MESH:D009569	4843	Chemical	Gene	START_ENTITY|dobj|production production|nmod|regulation regulation|amod|END_ENTITY	Unconjugated bilirubin modulates nitric_oxide production via iNOS regulation .
21341550	0	nitric_oxide	72,84	iNOS	97,101	nitric oxide	iNOS	MESH:D009569	24599(Tax:10116)	Chemical	Gene	synthetase|compound|START_ENTITY synthetase|appos|END_ENTITY	Increased testicular 8-hydroxy-2 ' - deoxyguanosine -LRB- 8-OHdG -RRB- and inducible nitric_oxide synthetase -LRB- iNOS -RRB- and nuclear factor kB -LRB- NF-kB -RRB- expressions in experimental rat varicocele .
21398123	0	nitric_oxide	76,88	iNOS	99,103	nitric oxide	iNOS	MESH:D009569	4843	Chemical	Gene	inhibitors|nmod|START_ENTITY discovery|nmod|inhibitors synthase|nsubj|discovery synthase|dobj|END_ENTITY	The discovery of novel , potent and highly selective inhibitors of inducible nitric_oxide synthase -LRB- iNOS -RRB- .
21684157	0	nitric_oxide	53,65	iNOS	76,80	nitric oxide	iNOS	MESH:D009569	4843	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Novel nanomolar imidazo -LSB- 4,5-b -RSB- pyridines as selective nitric_oxide synthase -LRB- iNOS -RRB- inhibitors : SAR and structural insights .
21771629	4	nitric_oxide	648,660	iNOS	671,675	nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	In addition , expression of cyclooxygenase-2 -LRB- COX-2 -RRB- and inducible nitric_oxide synthase -LRB- iNOS -RRB- genes was reduced , as evidenced by Western blot and luciferase reporter assays for COX-2 and iNOS .
21895774	0	nitric_oxide	10,22	iNOS	33,37	nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Inducible nitric_oxide synthase -LRB- iNOS -RRB- and a-melanocyte-stimulating hormones of iNOS origin play important roles in the allergic_reactions of atopic_dermatitis in mice .
21906467	0	nitric_oxide	37,49	iNOS	79,83	nitric oxide	iNOS	MESH:D009569	51477	Chemical	Gene	production|amod|START_ENTITY curcumin|nmod|production curcumin|nmod|END_ENTITY	-LSB- Effect of curcumin on IL-17-induced nitric_oxide production and expression of iNOS in human keratinocytes -RSB- .
21915762	0	nitric_oxide	45,57	iNOS	80,84	nitric oxide	iNOS	MESH:D009569	24599(Tax:10116)	Chemical	Gene	overproduction|nmod|START_ENTITY overproduction|nmod|END_ENTITY	Lipopolysaccharide-induced overproduction of nitric_oxide and overexpression of iNOS and interleukin-1b proteins in zinc-deficient rats .
21986586	0	nitric_oxide	46,58	iNOS	69,73	nitric oxide	iNOS	MESH:D009569	4843	Chemical	Gene	Identification|nmod|START_ENTITY synthase|nsubj|Identification synthase|xcomp|inhibitors inhibitors|dep|END_ENTITY	Identification and SAR of selective inducible nitric_oxide synthase -LRB- iNOS -RRB- dimerization inhibitors .
22050043	0	nitric_oxide	25,37	iNOS	48,52	nitric oxide	iNOS	MESH:D009569	4843	Chemical	Gene	xpression|nmod|START_ENTITY synthase|nsubj|xpression synthase|dobj|END_ENTITY	xpression of inducible nitric_oxide synthase -LRB- iNOS -RRB- in the azoospermic human testis .
22223460	0	nitric_oxide	81,93	iNOS	5,9	nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	relaxation|amod|START_ENTITY role|nmod|relaxation suggest|dobj|role suggest|nsubj|mRNA mRNA|compound|END_ENTITY	High iNOS mRNA and protein localization during late pregnancy suggest a role for nitric_oxide in mouse pubic symphysis relaxation .
22414378	0	nitric_oxide	142,154	iNOS	165,169	nitric oxide	iNOS	MESH:D009569	4843	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Reproducibility and intraindividual variation over days in buccal cell DNA methylation of two asthma genes , interferon y -LRB- IFNy -RRB- and inducible nitric_oxide synthase -LRB- iNOS -RRB- .
22609742	0	nitric_oxide	83,95	iNOS	106,110	nitric oxide	iNOS	MESH:D009569	4843	Chemical	Gene	START_ENTITY|dobj|inhibitors inhibitors|appos|END_ENTITY	Extensive ligand-based modeling and in silico screening reveal nanomolar inducible nitric_oxide synthase -LRB- iNOS -RRB- inhibitors .
23201648	0	nitric_oxide	40,52	iNOS	63,67	nitric oxide	iNOS	MESH:D009569	24599(Tax:10116)	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Pharmacological inhibition of inducible nitric_oxide synthase -LRB- iNOS -RRB- and nicotinamide_adenine_dinucleotide_phosphate -LRB- NADPH -RRB- oxidase , convalesce behavior and biochemistry of hypertension induced vascular_dementia in rats .
23410122	0	nitric_oxide	34,46	iNOS	65,69	nitric oxide	iNOS	MESH:D009569	282876(Tax:9913)	Chemical	Gene	enzymes|amod|START_ENTITY expression|nmod|enzymes expression|dep|END_ENTITY	Immunohistochemical expression of nitric_oxide synthase enzymes -LRB- iNOS , eNOS , nNOS -RRB- in the estrual and luteal phases of the sexual cycle in the cow oviduct .
24040305	0	nitric_oxide	72,84	iNOS	95,99	nitric oxide	iNOS	MESH:D009569	4843	Chemical	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Inorganic polyphosphate suppresses lipopolysaccharide-induced inducible nitric_oxide synthase -LRB- iNOS -RRB- expression in macrophages .
24211345	0	nitric_oxide	14,26	iNOS	88,92	nitric oxide	iNOS	MESH:D009569	4843	Chemical	Gene	Inhibition|nmod|START_ENTITY target|nsubj|Inhibition target|nmod|bladder_tumors bladder_tumors|acl:relcl|express express|dobj|END_ENTITY	Inhibition of nitric_oxide is a good therapeutic target for bladder_tumors that express iNOS .
24587191	0	nitric_oxide	17,29	iNOS	95,99	nitric oxide	iNOS	MESH:D009569	4843	Chemical	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	Elevated exhaled nitric_oxide in allergen-provoked asthma is associated with airway epithelial iNOS .
24740875	4	nitric_oxide	552,564	iNOS	575,579	nitric oxide	IL-6	MESH:D009569	3569	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Irisflorentin markedly reduces the transcriptional and translational levels of inducible nitric_oxide synthase -LRB- iNOS -RRB- as well as the production of NO .
24744158	3	nitric_oxide	439,451	iNOS	462,466	nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Here , we show that dieckol suppressed lipopolysaccharide -LRB- LPS -RRB- - induced inducible nitric_oxide synthase -LRB- iNOS -RRB- expression in mouse leukemic macrophage Raw264 .7 cells .
25106115	0	nitric_oxide	28,40	iNOS	51,55	nitric oxide	iNOS	MESH:D009569	4843	Chemical	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Downregulation of inducible nitric_oxide synthase -LRB- iNOS -RRB- expression is implicated in the antiviral activity of acetylsalicylic_acid in HCV-expressing cells .
25178323	0	nitric_oxide	10,22	iNOS	44,48	nitric oxide	iNOS	MESH:D009569	4843	Chemical	Gene	START_ENTITY|dobj|expression expression|appos|END_ENTITY	Inducible nitric_oxide synthase expression -LRB- iNOS -RRB- in chronic_viral_hepatitis and its correlation with liver_fibrosis .
25234194	0	nitric_oxide	24,36	iNOS	126,130	nitric oxide	iNOS	MESH:D009569	24599(Tax:10116)	Chemical	Gene	Modulation|nmod|START_ENTITY synthase|nsubj|Modulation synthase|xcomp|responses responses|nmod|exercise exercise|nmod|antagonism antagonism|amod|END_ENTITY	Modulation of inducible nitric_oxide synthase -LRB- iNOS -RRB- expression and cardiovascular responses during static exercise following iNOS antagonism within the ventrolateral medulla .
25234194	0	nitric_oxide	24,36	iNOS	47,51	nitric oxide	iNOS	MESH:D009569	24599(Tax:10116)	Chemical	Gene	Modulation|nmod|START_ENTITY synthase|nsubj|Modulation synthase|xcomp|responses responses|dep|END_ENTITY	Modulation of inducible nitric_oxide synthase -LRB- iNOS -RRB- expression and cardiovascular responses during static exercise following iNOS antagonism within the ventrolateral medulla .
26690069	0	nitric_oxide	25,37	iNOS	48,52	nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Correlation of inducible nitric_oxide synthase -LRB- iNOS -RRB- inhibition with TNF-a , caspase-1 , FasL and TLR-3 in pathogenesis of rabies in mouse model .
26730330	0	nitric_oxide	49,61	iNOS	72,76	nitric oxide	iNOS	MESH:D009569	24599(Tax:10116)	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Aloe vera toxic effects : expression of inducible nitric_oxide synthase -LRB- iNOS -RRB- in testis of Wistar rat .
7525557	0	nitric_oxide	19,31	iNOS	42,46	nitric oxide	iNOS	MESH:D009569	24599(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|expression expression|appos|END_ENTITY	Cytokine-inducible nitric_oxide synthase -LRB- iNOS -RRB- expression in cardiac myocytes .
7534733	0	nitric_oxide	61,73	iNOS	84,88	nitric oxide	iNOS	MESH:D009569	4843	Chemical	Gene	synthase|amod|START_ENTITY form|nmod|synthase regulation|nmod|form Studies|nmod|regulation Studies|appos|END_ENTITY	Studies on the molecular regulation of the inducible form of nitric_oxide synthase -LRB- iNOS -RRB- in insulin-producing cells .
7542498	0	nitric_oxide	38,50	iNOS	61,65	nitric oxide	iNOS	MESH:D009569	4843	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Human mononuclear phagocyte inducible nitric_oxide synthase -LRB- iNOS -RRB- : analysis of iNOS mRNA , iNOS protein , biopterin , and nitric_oxide production by blood monocytes and peritoneal macrophages .
7542498	0	nitric_oxide	38,50	iNOS	80,84	nitric oxide	iNOS	MESH:D009569	4843	Chemical	Gene	synthase|compound|START_ENTITY synthase|dep|analysis analysis|nmod|mRNA mRNA|amod|END_ENTITY	Human mononuclear phagocyte inducible nitric_oxide synthase -LRB- iNOS -RRB- : analysis of iNOS mRNA , iNOS protein , biopterin , and nitric_oxide production by blood monocytes and peritoneal macrophages .
7542498	0	nitric_oxide	38,50	iNOS	91,95	nitric oxide	iNOS	MESH:D009569	4843	Chemical	Gene	synthase|compound|START_ENTITY END_ENTITY|nsubj|synthase	Human mononuclear phagocyte inducible nitric_oxide synthase -LRB- iNOS -RRB- : analysis of iNOS mRNA , iNOS protein , biopterin , and nitric_oxide production by blood monocytes and peritoneal macrophages .
8537148	0	nitric_oxide	64,76	iNOS	87,91	nitric oxide	iNOS	MESH:D009569	24599(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY therapy|nmod|expression Effects|nmod|therapy synthase|nsubj|Effects synthase|dobj|END_ENTITY	Effects of immunosuppressive therapy on expression of inducible nitric_oxide synthase -LRB- iNOS -RRB- during cardiac allograft rejection .
8612552	0	nitric_oxide	10,22	iNOS	105,109	nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|synthase synthase|dep|identification identification|nmod|END_ENTITY	Inducible nitric_oxide synthase -LRB- iNOS -RRB- in pancreatic islets of nonobese diabetic mice : identification of iNOS - expressing cells and relationships to cytokines expressed in the islets .
8612552	0	nitric_oxide	10,22	iNOS	33,37	nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|synthase synthase|appos|END_ENTITY	Inducible nitric_oxide synthase -LRB- iNOS -RRB- in pancreatic islets of nonobese diabetic mice : identification of iNOS - expressing cells and relationships to cytokines expressed in the islets .
8812642	0	nitric_oxide	121,133	iNOS	23,27	nitric oxide	iNOS	MESH:D009569	4843	Chemical	Gene	activation|amod|START_ENTITY production|nmod|activation evidence|nmod|production review|dobj|evidence review|nsubj|Regulation Regulation|nmod|Expression Expression|compound|END_ENTITY	Cytokine Regulation of iNOS Expression in Human Glial Cells In this report , we review the evidence for the production of nitric_oxide following cytokine activation of the inducible form of nitric_oxide synthase by central nervous system glial cells , with particular reference to cells of human origin .
8812642	0	nitric_oxide	189,201	iNOS	23,27	nitric oxide	iNOS	MESH:D009569	4843	Chemical	Gene	synthase|amod|START_ENTITY form|nmod|synthase activation|nmod|form production|nmod|activation evidence|nmod|production review|dobj|evidence review|nsubj|Regulation Regulation|nmod|Expression Expression|compound|END_ENTITY	Cytokine Regulation of iNOS Expression in Human Glial Cells In this report , we review the evidence for the production of nitric_oxide following cytokine activation of the inducible form of nitric_oxide synthase by central nervous system glial cells , with particular reference to cells of human origin .
8864133	0	nitric_oxide	42,54	iNOS	65,69	nitric oxide	iNOS	MESH:D009569	24599(Tax:10116)	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Gadolinium_chloride inhibits Kupffer cell nitric_oxide synthase -LRB- iNOS -RRB- induction .
9021921	0	nitric_oxide	100,112	iNOS	131,135	nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	production|nmod|START_ENTITY production|nmod|mRNA mRNA|amod|END_ENTITY	Preactivation exposure of RAW 264.7 cells to taurine_chloramine attenuates subsequent production of nitric_oxide and expression of iNOS mRNA .
9151890	0	nitric_oxide	104,116	iNOS	127,131	nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Suppression of herpes_simplex_virus_type_1 _ -LRB- HSV-1 -RRB- - induced pneumonia in mice by inhibition of inducible nitric_oxide synthase -LRB- iNOS , NOS2 -RRB- .
9164857	0	nitric_oxide	75,87	iNOS	58,62	nitric oxide	iNOS	MESH:D009569	24599(Tax:10116)	Chemical	Gene	isoform|nmod|START_ENTITY isoform|appos|END_ENTITY	Expression of the calcium-independent cytokine-inducible -LRB- iNOS -RRB- isoform of nitric_oxide synthase in rat placenta .
9405166	0	nitric_oxide	135,147	iNOS	163,167	nitric oxide	iNOS	MESH:D009569	4843	Chemical	Gene	-|compound|START_ENTITY -|dep|END_ENTITY	Tumor_necrosis_factor_alpha -LRB- TNF_alpha -RRB- is cardiodepressant in pathophysiologically relevant concentrations without inducing inducible nitric_oxide - -LRB- NO -RRB- - synthase -LRB- iNOS -RRB- or triggering serious cytotoxicity .
9515007	0	nitric_oxide	134,146	iNOS	87,91	nitric oxide	iNOS	MESH:D009569	24599(Tax:10116)	Chemical	Gene	function|nmod|START_ENTITY function|nmod|END_ENTITY	Regulation of cardiac myocyte contractile function by inducible_nitric_oxide_synthase -LRB- iNOS -RRB- : mechanisms of contractile depression by nitric_oxide .
9554868	0	nitric_oxide	67,79	iNOS	90,94	nitric oxide	iNOS	MESH:D009569	4843	Chemical	Gene	inhibitors|nmod|START_ENTITY synthase|nsubj|inhibitors synthase|dobj|END_ENTITY	2-Iminohomopiperidinium_salts as selective inhibitors of inducible nitric_oxide synthase -LRB- iNOS -RRB- .
9560010	0	nitric_oxide	10,22	iNOS	33,37	nitric oxide	iNOS	MESH:D009569	4843	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Inducible nitric_oxide synthase -LRB- iNOS -RRB- - like immunoreactivity in argyrophilic , tau-positive astrocytes in progressive_supranuclear_palsy .
9588181	0	nitric_oxide	10,22	iNOS	33,37	nitric oxide	iNOS	MESH:D009569	4843	Chemical	Gene	synthase|nsubj|START_ENTITY synthase|xcomp|expression expression|dep|END_ENTITY	Inducible nitric_oxide synthase -LRB- iNOS -RRB- expression in human monocytes triggered by beta-endorphin through an increase in cAMP .
9689595	0	nitric_oxide	10,22	iNOS	33,37	nitric oxide	iNOS	MESH:D009569	4843	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Inducible nitric_oxide synthase -LRB- iNOS -RRB- in the human heart : expression and localization in congestive_heart_failure .
9704020	0	nitric_oxide	52,64	iNOS	143,147	nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	gene|amod|START_ENTITY Analysis|nmod|gene Analysis|dep|characterization characterization|nmod|differences differences|nmod|promoters promoters|compound|END_ENTITY	Analysis of the cytokine-stimulated human inducible nitric_oxide synthase -LRB- iNOS -RRB- gene : characterization of differences between human and mouse iNOS promoters .
9704020	0	nitric_oxide	52,64	iNOS	75,79	nitric oxide	iNOS	MESH:D009569	4843	Chemical	Gene	gene|amod|START_ENTITY gene|dep|END_ENTITY	Analysis of the cytokine-stimulated human inducible nitric_oxide synthase -LRB- iNOS -RRB- gene : characterization of differences between human and mouse iNOS promoters .
9794431	0	nitric_oxide	66,78	iNOS	221,225	nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|parataxis|required required|nmod|inhibition inhibition|nmod|expression expression|amod|END_ENTITY	Activation of the RON receptor tyrosine kinase inhibits inducible nitric_oxide synthase -LRB- iNOS -RRB- expression by murine peritoneal exudate macrophages : phosphatidylinositol-3 kinase is required for RON-mediated inhibition of iNOS expression .
9794431	0	nitric_oxide	66,78	iNOS	89,93	nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Activation of the RON receptor tyrosine kinase inhibits inducible nitric_oxide synthase -LRB- iNOS -RRB- expression by murine peritoneal exudate macrophages : phosphatidylinositol-3 kinase is required for RON-mediated inhibition of iNOS expression .
9802559	0	nitric_oxide	116,128	iNOS	139,143	nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Lipopolysaccharide -LRB- LPS -RRB- stimulates the production of tumor_necrosis_factor _ -LRB- TNF -RRB- - alpha and expression of inducible nitric_oxide synthase -LRB- iNOS -RRB- by osteoclasts -LRB- OCL -RRB- in murine bone marrow cell culture .
9802972	0	nitric_oxide	94,106	iNOS	119,123	nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Immune suppression by recombinant interleukin -LRB- rIL -RRB- -12 involves interferon gamma induction of nitric_oxide synthase 2 -LRB- iNOS -RRB- activity : inhibitors of NO generation reveal the extent of rIL-12 vaccine adjuvant effect .
9918806	2	nitric_oxide	356,368	iNOS	321,325	nitric oxide	iNOS	MESH:D009569	18126(Tax:10090)	Chemical	Gene	production|nmod|START_ENTITY END_ENTITY|nmod|production	Both lipopolysaccharide and TNF-alpha synergize with IFN-gamma in the expression of iNOS with subsequent production of nitric_oxide .
11134960	0	nitric_oxide	111,123	inducible_nitric_oxide_synthase	55,86	nitric oxide	inducible nitric oxide synthase	MESH:D009569	18126(Tax:10090)	Chemical	Gene	involved|nmod|START_ENTITY involved|nmod|inhibition inhibition|nmod|expression expression|amod|END_ENTITY	Octamer_binding_protein-1 is involved in inhibition of inducible_nitric_oxide_synthase expression by exogenous nitric_oxide in murine liver cells .
11241130	0	nitric_oxide	53,65	inducible_nitric_oxide_synthase	14,45	nitric oxide	inducible nitric oxide synthase	MESH:D009569	24599(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|limits limits|amod|END_ENTITY	Inhibition of inducible_nitric_oxide_synthase limits nitric_oxide production and experimental aneurysm expansion .
11587565	0	nitric_oxide	123,135	inducible_nitric_oxide_synthase	139,170	nitric oxide	inducible nitric oxide synthase	MESH:D009569	18126(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Antioxidant enzymes suppress nitric_oxide production through the inhibition of NF-kappa_B activation : role of H -LRB- 2 -RRB- O -LRB- 2 -RRB- and nitric_oxide in inducible_nitric_oxide_synthase expression in macrophages .
12851743	0	nitric_oxide	17,29	inducible_nitric_oxide_synthase	123,154	nitric oxide	inducible nitric oxide synthase	MESH:D009569	4843	Chemical	Gene	biosynthesis|amod|START_ENTITY reduces|dobj|biosynthesis reduces|advcl|downregulating downregulating|dobj|expression expression|nmod|END_ENTITY	Propofol reduces nitric_oxide biosynthesis in lipopolysaccharide-activated macrophages by downregulating the expression of inducible_nitric_oxide_synthase .
14657339	0	nitric_oxide	101,113	inducible_nitric_oxide_synthase	55,86	nitric oxide	inducible nitric oxide synthase	MESH:D009569	4843	Chemical	Gene	inhibition|amod|START_ENTITY preventing|dobj|inhibition up-regulates|advcl|preventing up-regulates|dobj|activity activity|nmod|END_ENTITY	Myeloperoxidase up-regulates the catalytic activity of inducible_nitric_oxide_synthase by preventing nitric_oxide feedback inhibition .
15818094	0	nitric_oxide	45,57	inducible_nitric_oxide_synthase	70,101	nitric oxide	inducible nitric oxide synthase	MESH:D009569	18126(Tax:10090)	Chemical	Gene	START_ENTITY|acl|produced produced|nmod|END_ENTITY	Immune_dysfunction in endotoxicosis : role of nitric_oxide produced by inducible_nitric_oxide_synthase .
17854382	0	nitric_oxide	17,29	inducible_nitric_oxide_synthase	113,144	nitric oxide	inducible nitric oxide synthase	MESH:D009569	18126(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY involved|nsubjpass|synthase involved|nmod|expression expression|compound|END_ENTITY	Reduced neuronal nitric_oxide synthase is involved in ischemia-induced hippocampal neurogenesis by up-regulating inducible_nitric_oxide_synthase expression .
21958548	0	nitric_oxide	31,43	inducible_nitric_oxide_synthase	58,89	nitric oxide	inducible nitric oxide synthase	MESH:D009569	4843	Chemical	Gene	production|amod|START_ENTITY regulation|nmod|production regulation|nmod|END_ENTITY	Oxygen-dependent regulation of nitric_oxide production by inducible_nitric_oxide_synthase .
22101361	0	nitric_oxide	15,27	inducible_nitric_oxide_synthase	113,144	nitric oxide	inducible nitric oxide synthase	MESH:D009569	18126(Tax:10090)	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|dep|role role|nmod|cytokines cytokines|nmod|activation activation|amod|END_ENTITY	Involvement of nitric_oxide on the pathogenesis of irinotecan-induced intestinal_mucositis : role of cytokines on inducible_nitric_oxide_synthase activation .
7541386	0	nitric_oxide	8,20	inducible_nitric_oxide_synthase	93,124	nitric oxide	inducible nitric oxide synthase	MESH:D009569	24599(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY mediated|nsubjpass|production mediated|nmod|expression expression|amod|END_ENTITY	Hepatic nitric_oxide production following acute endotoxemia in rats is mediated by increased inducible_nitric_oxide_synthase gene expression .
7688152	0	nitric_oxide	75,87	inducible_nitric_oxide_synthase	34,65	nitric oxide	inducible nitric oxide synthase	MESH:D009569	24599(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY inhibits|dobj|synthesis inhibits|dep|oligodeoxynucleotide oligodeoxynucleotide|xcomp|END_ENTITY	Antisense oligodeoxynucleotide to inducible_nitric_oxide_synthase inhibits nitric_oxide synthesis in rat pulmonary artery smooth muscle cells in culture .
9029115	0	nitric_oxide	83,95	inducible_nitric_oxide_synthase	19,50	nitric oxide	inducible nitric oxide synthase	MESH:D009569	18126(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY correlate|nmod|production correlate|nsubj|Expression Expression|nmod|protein protein|compound|END_ENTITY	Expression of lung inducible_nitric_oxide_synthase protein does not correlate with nitric_oxide production in vivo in a pulmonary immune response against Cryptococcus_neoformans .
9345316	0	nitric_oxide	105,117	inducible_nitric_oxide_synthase	14,45	nitric oxide	inducible nitric oxide synthase	MESH:D009569	18126(Tax:10090)	Chemical	Gene	accounts|amod|START_ENTITY formation|nmod|accounts Inhibition|nmod|formation Inhibition|nmod|expression expression|amod|END_ENTITY	Inhibition of inducible_nitric_oxide_synthase expression and stimulation of the endothelial formation of nitric_oxide most likely accounts for the protective effect of 2 - -LRB- allylthio -RRB- pyrazine in a murine model of endotoxemia .
9400741	0	nitric_oxide	63,75	inducible_nitric_oxide_synthase	14,45	nitric oxide	inducible nitric oxide synthase	MESH:D009569	24599(Tax:10116)	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of inducible_nitric_oxide_synthase and formation of nitric_oxide by alveolar macrophages : an interspecies comparison .
9515007	0	nitric_oxide	134,146	inducible_nitric_oxide_synthase	54,85	nitric oxide	inducible nitric oxide synthase	MESH:D009569	24599(Tax:10116)	Chemical	Gene	function|nmod|START_ENTITY function|nmod|iNOS iNOS|amod|END_ENTITY	Regulation of cardiac myocyte contractile function by inducible_nitric_oxide_synthase -LRB- iNOS -RRB- : mechanisms of contractile depression by nitric_oxide .
9877390	0	nitric_oxide	67,79	inducible_nitric_oxide_synthase	17,48	nitric oxide	inducible nitric oxide synthase	MESH:D009569	18126(Tax:10090)	Chemical	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|END_ENTITY	Up-regulation of inducible_nitric_oxide_synthase and production of nitric_oxide by the Swarm rat and human chondrosarcoma .
11341781	0	nitric_oxide	87,99	inos	110,114	nitric oxide	inos	MESH:D009569	18126(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|activity activity|appos|END_ENTITY	Relative contribution of hemopoietic and pulmonary parenchymal cells to lung inducible nitric_oxide synthase -LRB- inos -RRB- activity in murine endotoxemia .
10754469	0	nitric_oxide	10,22	insulin	59,66	nitric oxide	insulin	MESH:D009569	3630	Chemical	Gene	synthesis|compound|START_ENTITY synthesis|dep|link link|nmod|resistance resistance|compound|END_ENTITY	Defective nitric_oxide synthesis : a link between metabolic insulin resistance , sympathetic overactivity and cardiovascular_morbidity .
11642716	1	nitric_oxide	113,125	insulin	154,161	nitric oxide	insulin	MESH:D009569	3630	Chemical	Gene	START_ENTITY|nmod|development development|nmod|signalling signalling|compound|END_ENTITY	Recent data support the possible role of nitric_oxide -LRB- NO * -RRB- in the development of insulin signalling .
11903029	0	nitric_oxide	58,70	insulin	21,28	nitric oxide	insulin	MESH:D009569	3630	Chemical	Gene	START_ENTITY|nsubj|Relationship Relationship|nmod|resistance resistance|compound|END_ENTITY	Relationship between insulin resistance and an endogenous nitric_oxide synthase inhibitor .
12086958	0	nitric_oxide	139,151	insulin	40,47	nitric oxide	insulin	MESH:D009569	3630	Chemical	Gene	pathways|amod|START_ENTITY role|nmod|pathways regulation|dep|role regulation|nmod|rho rho|acl|signaling signaling|nmod|END_ENTITY	Negative regulation of rho signaling by insulin and its impact on actin cytoskeleton organization in vascular smooth muscle cells : role of nitric_oxide and cyclic_guanosine_monophosphate signaling pathways .
15446471	0	nitric_oxide	25,37	insulin	103,110	nitric oxide	insulin	MESH:D009569	105613195	Chemical	Gene	production|compound|START_ENTITY Inhibition|nmod|production influences|nsubj|Inhibition influences|dobj|metabolism metabolism|nmod|concentrations concentrations|compound|END_ENTITY	Inhibition of endogenous nitric_oxide production influences ovine hindlimb metabolism independently of insulin concentrations .
16151016	0	nitric_oxide	39,51	insulin	10,17	nitric oxide	insulin	MESH:D009569	3630	Chemical	Gene	release|amod|START_ENTITY affecting|dobj|release resistance|acl|affecting resistance|compound|END_ENTITY	Selective insulin resistance affecting nitric_oxide release but not plasminogen_activator_inhibitor-1 synthesis in fibroblasts from insulin-resistant individuals .
17941991	0	nitric_oxide	60,72	insulin	13,20	nitric oxide	insulin	MESH:D009569	3630	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Induction Induction|nmod|END_ENTITY	Induction of insulin secretion in engineered liver cells by nitric_oxide .
18785581	0	nitric_oxide	48,60	insulin	22,29	nitric oxide	insulin	MESH:D009569	3630	Chemical	Gene	therapy|nmod|START_ENTITY therapy|compound|END_ENTITY	-LSB- Effects of intensive insulin therapy on plasma nitric_oxide and endothelin-1 levels in patients undergoing cardiac surgery under cardiopulmonary bypass -RSB- .
21530944	0	nitric_oxide	11,23	insulin	89,96	nitric oxide	insulin	MESH:D009569	3630	Chemical	Gene	Effects|nmod|START_ENTITY synthase|nsubj|Effects synthase|dobj|blockade blockade|nmod|secretion secretion|compound|END_ENTITY	Effects of nitric_oxide synthase blockade on dorsal vagal stimulation-induced pancreatic insulin secretion .
22064745	0	nitric_oxide	107,119	insulin	26,33	nitric oxide	insulin	MESH:D009569	105613195	Chemical	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|effect effect|nmod|infusion infusion|compound|END_ENTITY	The effect of intravenous insulin infusion on renal blood flow in conscious sheep is partially mediated by nitric_oxide but not by prostaglandins .
23370528	0	nitric_oxide	23,35	insulin	146,153	nitric oxide	insulin	MESH:D009569	3630	Chemical	Gene	synthesis|amod|START_ENTITY inhibition|nmod|synthesis produces|nsubj|inhibition produces|nmod|clearance clearance|compound|END_ENTITY	Systemic inhibition of nitric_oxide synthesis in non-diabetic individuals produces a significant deterioration in glucose tolerance by increasing insulin clearance and inhibiting insulin secretion .
23742634	0	nitric_oxide	82,94	insulin	59,66	nitric oxide	insulin	MESH:D009569	3630	Chemical	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|response response|nmod|iontophoresis iontophoresis|nmod|END_ENTITY	The microvascular response to transdermal iontophoresis of insulin is mediated by nitric_oxide .
24328140	0	nitric_oxide	34,46	insulin	67,74	nitric oxide	insulin	MESH:D009569	3630	Chemical	Gene	START_ENTITY|xcomp|synthase synthase|xcomp|promote promote|dobj|resistance resistance|compound|END_ENTITY	von_Willebrand factor antagonizes nitric_oxide synthase to promote insulin resistance during hypoxia .
8083357	1	nitric_oxide	111,123	insulin	91,98	nitric oxide	insulin	MESH:D009569	3630	Chemical	Gene	release|amod|START_ENTITY increase|dobj|release action|acl|increase action|nmod|END_ENTITY	A novel action of insulin to increase nitric_oxide release .
9059567	0	nitric_oxide	15,27	insulin	66,73	nitric oxide	insulin	MESH:D009569	3630	Chemical	Gene	Involvement|nmod|START_ENTITY induced|nsubj|Involvement induced|dobj|secretion secretion|compound|END_ENTITY	Involvement of nitric_oxide in arginine , but not glucose , induced insulin secretion in normal men .
12701063	0	nitric_oxide	86,98	insulin-like_growth_factor-1	23,51	nitric oxide	insulin-like growth factor-1	MESH:D009569	24482(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Interactive effects of insulin-like_growth_factor-1 and beta-estradiol on endothelial nitric_oxide synthase activity in rat aortic endothelial cells .
11758822	0	nitric_oxide	60,72	integrin-linked_kinase	18,40	nitric oxide	integrin-linked kinase	MESH:D009569	170922(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Downregulation of integrin-linked_kinase mRNA expression by nitric_oxide in rat glomerular mesangial cells .
11839570	0	nitric_oxide	101,113	intercellular_adhesion_molecule-1	51,84	nitric oxide	intercellular adhesion molecule-1	MESH:D009569	25464(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Retinal_vascular_endothelial_growth_factor induces intercellular_adhesion_molecule-1 and endothelial nitric_oxide synthase expression and initiates early diabetic_retinal leukocyte adhesion in vivo .
10193423	0	nitric_oxide	28,40	interferon-gamma	60,76	nitric oxide	interferon-gamma	MESH:D009569	15978(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Candida_albicans suppresses nitric_oxide -LRB- NO -RRB- production by interferon-gamma -LRB- IFN-gamma -RRB- and lipopolysaccharide -LRB- LPS -RRB- - stimulated murine peritoneal macrophages .
10210769	0	nitric_oxide	116,128	interferon-gamma	35,51	nitric oxide	interferon-gamma	MESH:D009569	15978(Tax:10090)	Chemical	Gene	production|nmod|START_ENTITY enhances|nmod|production enhances|nsubj|Interleukin-10 Interleukin-10|nmod|combination combination|nmod|END_ENTITY	Interleukin-10 in combination with interferon-gamma and tumor_necrosis_factor-alpha enhances in vitro production of nitric_oxide by murine resident paritoneal macrophage .
10473178	0	nitric_oxide	14,26	interferon-gamma	78,94	nitric oxide	interferon-gamma	MESH:D009569	15978(Tax:10090)	Chemical	Gene	Production|nmod|START_ENTITY macrophages|nsubj|Production macrophages|advcl|priming priming|nmod|END_ENTITY	Production of nitric_oxide in mouse peritoneal macrophages after priming with interferon-gamma by the stem of Sinomenium acutum .
10479148	0	nitric_oxide	141,153	interferon-gamma	97,113	nitric oxide	interferon-gamma	MESH:D009569	3458	Chemical	Gene	role|nmod|START_ENTITY Modulation|dep|role Modulation|nmod|growth growth|nmod|Listeria_monocytogenes Listeria_monocytogenes|nmod|cells cells|nmod|END_ENTITY	Modulation of intracellular growth of Listeria_monocytogenes in human enterocyte Caco-2 cells by interferon-gamma and interleukin-6 : role of nitric_oxide and cooperation with antibiotics .
10491339	0	nitric_oxide	17,29	interferon-gamma	44,60	nitric oxide	interferon-gamma	MESH:D009569	3458	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Up-regulation of nitric_oxide production by interferon-gamma in cultured peritoneal macrophages from patients with cirrhosis .
10592110	0	nitric_oxide	10,22	interferon-gamma	126,142	nitric oxide	interferon-gamma	MESH:D009569	3458	Chemical	Gene	START_ENTITY|nmod|macrophages macrophages|acl|stimulated stimulated|nmod|lipopolysaccharide lipopolysaccharide|amod|END_ENTITY	Inducible nitric_oxide synthase and nitric_oxide production in Leishmania_infantum-infected human macrophages stimulated with interferon-gamma and bacterial lipopolysaccharide .
10660117	0	nitric_oxide	10,22	interferon-gamma	76,92	nitric oxide	interferon-gamma	MESH:D009569	25712(Tax:10116)	Chemical	Gene	synthase|compound|START_ENTITY synthase|dep|expression expression|nmod|presence presence|nmod|END_ENTITY	Inducible nitric_oxide synthase in P11 cells : expression in the presence of interferon-gamma , lipopolysaccharide , and modified serum .
10699750	0	nitric_oxide	48,60	interferon-gamma	73,89	nitric oxide	interferon-gamma	MESH:D009569	15978(Tax:10090)	Chemical	Gene	synthase|amod|START_ENTITY induction|nmod|synthase induction|dep|END_ENTITY	Ionizing radiation potentiates the induction of nitric_oxide synthase by interferon-gamma -LRB- Ifn-gamma -RRB- or Ifn-gamma and lipopolysaccharide in bnl_cl .2 murine embryonic liver cells : role of hydrogen_peroxide .
10825233	0	nitric_oxide	61,73	interferon-gamma	96,112	nitric oxide	interferon-gamma	MESH:D009569	25712(Tax:10116)	Chemical	Gene	isoform|nmod|START_ENTITY activation|nmod|isoform synthase|nsubj|activation synthase|nmod|END_ENTITY	Synergistic activation of NF-kappab and inducible isoform of nitric_oxide synthase induction by interferon-gamma and tumor_necrosis_factor-alpha in INS-1 cells .
10863529	0	nitric_oxide	48,60	interferon-gamma	73,89	nitric oxide	interferon-gamma	MESH:D009569	15978(Tax:10090)	Chemical	Gene	synthase|amod|START_ENTITY induction|nmod|synthase potentiates|dobj|induction potentiates|nmod|END_ENTITY	Ionizing radiation potentiates the induction of nitric_oxide synthase by interferon-gamma and/or lipopolysaccharide in murine macrophage cell lines .
10865190	0	nitric_oxide	55,67	interferon-gamma	137,153	nitric oxide	interferon-gamma	MESH:D009569	15978(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY Induction|nmod|synthase fails|nsubj|Induction fails|xcomp|prevent prevent|nmod|absence absence|nmod|END_ENTITY	Induction of tumor_necrosis_factor-alpha and inducible nitric_oxide synthase fails to prevent toxoplasmic_encephalitis in the absence of interferon-gamma in genetically resistant BALB/c mice .
11002987	0	nitric_oxide	93,105	interferon-gamma	29,45	nitric oxide	interferon-gamma	MESH:D009569	15978(Tax:10090)	Chemical	Gene	mechanism|amod|START_ENTITY macrophages|nmod|mechanism macrophages|nsubj|effects effects|nmod|END_ENTITY	Growth-inhibitory effects of interferon-gamma on Neospora caninum in murine macrophages by a nitric_oxide mechanism .
11136679	0	nitric_oxide	123,135	interferon-gamma	33,49	nitric oxide	interferon-gamma	MESH:D009569	15978(Tax:10090)	Chemical	Gene	induction|compound|START_ENTITY severity|nmod|induction autoimmune_myocarditis|dep|severity autoimmune_myocarditis|nmod|mice mice|amod|END_ENTITY	Lethal autoimmune_myocarditis in interferon-gamma receptor-deficient mice : enhanced disease severity by impaired inducible nitric_oxide synthase induction .
11159690	0	nitric_oxide	112,124	interferon-gamma	21,37	nitric oxide	interferon-gamma	MESH:D009569	15978(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|response response|nmod|END_ENTITY	Impaired response to interferon-gamma in activated macrophages due to tyrosine nitration of STAT1 by endogenous nitric_oxide .
11161444	0	nitric_oxide	72,84	interferon-gamma	136,152	nitric oxide	interferon-gamma	MESH:D009569	15978(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY results|nmod|production presentation|nmod|results presentation|parataxis|essential essential|nsubj|END_ENTITY	Antigen presentation to Th1 but not Th2 cells by macrophages results in nitric_oxide production and inhibition of T cell proliferation : interferon-gamma is essential but insufficient .
11347274	0	nitric_oxide	93,105	interferon-gamma	233,249	nitric oxide	interferon-gamma	MESH:D009569	15978(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY required|nmod|production required|parataxis|involved involved|nmod|END_ENTITY	Interferon-gamma - and lipopolysaccharide-induced tumor necrosis factor-alpha is required for nitric_oxide production : tumor necrosis factor-alpha and nitric_oxide are independently involved in the killing of Mycobacterium microti in interferon-gamma - and lipopolysaccharide-treated J774A .1 cells .
11501040	0	nitric_oxide	86,98	interferon-gamma	38,54	nitric oxide	interferon-gamma	MESH:D009569	100008602(Tax:9986)	Chemical	Gene	production|compound|START_ENTITY production|amod|END_ENTITY	Dithiolane analogs of lignans inhibit interferon-gamma and lipopolysaccharide-induced nitric_oxide production in macrophages .
11679202	0	nitric_oxide	92,104	interferon-gamma	160,176	nitric oxide	interferon-gamma	MESH:D009569	3458	Chemical	Gene	gene|amod|START_ENTITY effect|nmod|gene effect|acl|stimulated stimulated|nmod|END_ENTITY	Inhibitory effect of ethyl_acetate fraction from Cudrania tricuspidata on the expression of nitric_oxide synthase gene in RAW 264.7 macrophages stimulated with interferon-gamma and lipopolysaccharide .
11687972	0	nitric_oxide	150,162	interferon-gamma	27,43	nitric oxide	interferon-gamma	MESH:D009569	15978(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY expression|nmod|synthase enhances|nmod|expression enhances|nsubj|disruption disruption|nmod|END_ENTITY	Genetic disruption of host interferon-gamma drastically enhances the metastasis of pancreatic_adenocarcinoma through impaired expression of inducible nitric_oxide synthase .
11911993	0	nitric_oxide	24,36	interferon-gamma	51,67	nitric oxide	interferon-gamma	MESH:D009569	3458	Chemical	Gene	production|nmod|START_ENTITY stimulated|nsubj|production stimulated|nmod|END_ENTITY	Increased production of nitric_oxide stimulated by interferon-gamma from peripheral blood monocytes in patients with complex_regional_pain_syndrome .
11966872	0	nitric_oxide	177,189	interferon-gamma	147,163	nitric oxide	interferon-gamma	MESH:D009569	3458	Chemical	Gene	secretion|compound|START_ENTITY END_ENTITY|nmod|secretion	Up-regulation of inducible nitric_oxide synthase and nitric_oxide in Helicobacter_pylori-infected human gastric epithelial cells : possible role of interferon-gamma in polarized nitric_oxide secretion .
11966872	0	nitric_oxide	27,39	interferon-gamma	147,163	nitric oxide	interferon-gamma	MESH:D009569	3458	Chemical	Gene	Up-regulation|nmod|START_ENTITY synthase|nsubj|Up-regulation synthase|nmod|cells cells|dep|role role|nmod|END_ENTITY	Up-regulation of inducible nitric_oxide synthase and nitric_oxide in Helicobacter_pylori-infected human gastric epithelial cells : possible role of interferon-gamma in polarized nitric_oxide secretion .
12684085	0	nitric_oxide	70,82	interferon-gamma	106,122	nitric oxide	interferon-gamma	MESH:D009569	15978(Tax:10090)	Chemical	Gene	expression|compound|START_ENTITY nitric_oxide|dobj|expression nitric_oxide|nmod|END_ENTITY	Docosahexaenoic_acid suppresses nitric_oxide production and inducible nitric_oxide synthase expression in interferon-gamma plus lipopolysaccharide-stimulated murine macrophages by inhibiting the oxidative stress .
1371674	0	nitric_oxide	49,61	interferon-gamma	74,90	nitric oxide	interferon-gamma	MESH:D009569	15978(Tax:10090)	Chemical	Gene	synthase|amod|START_ENTITY induction|nmod|synthase inhibits|dobj|induction inhibits|nmod|END_ENTITY	Interleukin-10 -LRB- IL-10 -RRB- inhibits the induction of nitric_oxide synthase by interferon-gamma in murine macrophages .
14511384	0	nitric_oxide	72,84	interferon-gamma	18,34	nitric oxide	interferon-gamma	MESH:D009569	15978(Tax:10090)	Chemical	Gene	cells|amod|START_ENTITY induction|nmod|cells pathway|nmod|induction pathway|nsubj|pathway pathway|nmod|END_ENTITY	A pathway through interferon-gamma is the main pathway for induction of nitric_oxide upon stimulation with bacterial lipopolysaccharide in mouse peritoneal cells .
14960298	0	nitric_oxide	5,17	interferon-gamma	71,87	nitric oxide	interferon-gamma	MESH:D009569	3458	Chemical	Gene	production|compound|START_ENTITY production|dep|role role|nmod|END_ENTITY	High nitric_oxide production in autistic_disorder : a possible role for interferon-gamma .
17056198	0	nitric_oxide	144,156	interferon-gamma	113,129	nitric oxide	interferon-gamma	MESH:D009569	15978(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY synthase|compound|END_ENTITY	The radiosensitizing effect of immunoadjuvant OM-174 requires cooperation between immune and tumor cells through interferon-gamma and inducible nitric_oxide synthase .
17107743	0	nitric_oxide	68,80	interferon-gamma	42,58	nitric oxide	interferon-gamma	MESH:D009569	15978(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Chitooligosaccharides Chitooligosaccharides|nmod|combination combination|nmod|increase increase|amod|END_ENTITY	Chitooligosaccharides in combination with interferon-gamma increase nitric_oxide production via nuclear factor-kappaB activation in murine RAW264 .7 macrophages .
18457829	0	nitric_oxide	91,103	interferon-gamma	121,137	nitric oxide	interferon-gamma	MESH:D009569	15978(Tax:10090)	Chemical	Gene	production|nmod|START_ENTITY production|nmod|END_ENTITY	Inhibitor of sarco-endoplasmic_reticulum_Ca2 + - ATPase thapsigargin stimulates production of nitric_oxide and secretion of interferon-gamma .
19429329	0	nitric_oxide	24,36	interferon-gamma	78,94	nitric oxide	interferon-gamma	MESH:D009569	15978(Tax:10090)	Chemical	Gene	Expression|nmod|START_ENTITY synthase|nsubj|Expression synthase|nmod|macrophages macrophages|amod|END_ENTITY	Expression of inducible nitric_oxide synthase by Corydalis turtschaninovii on interferon-gamma stimulated macrophages .
22330085	0	nitric_oxide	24,36	interferon-gamma	104,120	nitric oxide	interferon-gamma	MESH:D009569	3458	Chemical	Gene	START_ENTITY|nmod|neutrophils neutrophils|nmod|patients patients|nmod|chronic_granulomatous_disease chronic_granulomatous_disease|nmod|treatment treatment|amod|END_ENTITY	Increased production of nitric_oxide by neutrophils from patients with chronic_granulomatous_disease on interferon-gamma treatment .
7509393	0	nitric_oxide	13,25	interferon-gamma	37,53	nitric oxide	interferon-gamma	MESH:D009569	281237(Tax:9913)	Chemical	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	Induction of nitric_oxide release by interferon-gamma inhibits vasodilation and cyclic_GMP increase in bovine isolated mesenteric arteries .
7518621	0	nitric_oxide	56,68	interferon-gamma	102,118	nitric oxide	interferon-gamma	MESH:D009569	15978(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY encoding|dobj|synthase gene|acl|encoding Promoter|nmod|gene confers|nsubj|Promoter confers|nmod|lipopolysaccharide lipopolysaccharide|amod|END_ENTITY	Promoter of the mouse gene encoding calcium-independent nitric_oxide synthase confers inducibility by interferon-gamma and bacterial lipopolysaccharide .
7524571	0	nitric_oxide	49,61	interferon-gamma	20,36	nitric oxide	interferon-gamma	MESH:D009569	25712(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY production|amod|END_ENTITY	Asbestos fibers and interferon-gamma up-regulate nitric_oxide production in rat alveolar macrophages .
7534727	0	nitric_oxide	64,76	interferon-gamma	27,43	nitric oxide	interferon-gamma	MESH:D009569	3458	Chemical	Gene	synthase|amod|START_ENTITY induction|nmod|synthase END_ENTITY|nmod|induction	-LSB- The synergistic effect of interferon-gamma on the induction of nitric_oxide synthase by lipopolysaccharide in vascular smooth muscle -RSB- .
7578879	0	nitric_oxide	95,107	interferon-gamma	42,58	nitric oxide	interferon-gamma	MESH:D009569	25712(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY vitro|nmod|production vitro|nmod|factor-alpha factor-alpha|compound|END_ENTITY	Effects of prolonged exposure in vitro to interferon-gamma and tumour necrosis factor-alpha on nitric_oxide and insulin production of rat pancreatic islets .
7648440	0	nitric_oxide	55,67	interferon-gamma	105,121	nitric oxide	interferon-gamma	MESH:D009569	15978(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY macrophages|nmod|production activation|nmod|macrophages activation|acl|killing killing|nmod|END_ENTITY	Direct activation of murine peritoneal macrophages for nitric_oxide production and tumor cell killing by interferon-gamma .
7688311	0	nitric_oxide	24,36	interferon-gamma	51,67	nitric oxide	interferon-gamma	MESH:D009569	3458	Chemical	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Induction of macrophage nitric_oxide production by interferon-gamma and tumor_necrosis_factor-alpha is enhanced by interleukin-10 .
7722422	0	nitric_oxide	26,38	interferon-gamma	53,69	nitric oxide	interferon-gamma	MESH:D009569	15978(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY increase|dobj|production increase|nmod|END_ENTITY	Immune complexes increase nitric_oxide production by interferon-gamma - stimulated murine macrophage-like J774 .16 cells .
8001633	4	nitric_oxide	1050,1062	interferon-gamma	979,995	nitric oxide	interferon-gamma	MESH:D009569	281237(Tax:9913)	Chemical	Gene	involvement|nmod|START_ENTITY suggests|dobj|involvement relaxation|acl:relcl|suggests relaxation|dep|/ /|dep|% %|nmod|END_ENTITY	Methyl-L-arginine -LRB- 1 mM -RRB- treatment during the 20-h preincubation also inhibited the interferon-gamma effect on bradykinin relaxation -LRB- -47 + / - 18 % for interferon-gamma and methyl-L-arginine -RRB- , which suggests involvement of nitric_oxide during the 20-h preincubation with interferon-gamma .
8030992	0	nitric_oxide	17,29	interferon-gamma	66,82	nitric oxide	interferon-gamma	MESH:D009569	25712(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY production|dep|effect effect|nmod|END_ENTITY	Asbestos-induced nitric_oxide production : synergistic effect with interferon-gamma .
8190027	0	nitric_oxide	30,42	interferon-gamma	10,26	nitric oxide	interferon-gamma	MESH:D009569	25712(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY Effect|nmod|production Effect|nmod|END_ENTITY	Effect of interferon-gamma on nitric_oxide hemoglobin production in endotoxin-treated rats and its synergism with interleukin 1 or tumor_necrosis_factor .
8564712	0	nitric_oxide	125,137	interferon-gamma	10,26	nitric oxide	interferon-gamma	MESH:D009569	15978(Tax:10090)	Chemical	Gene	synthase|amod|START_ENTITY induction|nmod|synthase macrophages|nmod|induction beta|nmod|macrophages synthesis|dep|beta induces|dobj|synthesis induces|nsubj|END_ENTITY	Exogenous interferon-gamma induces endogenous synthesis of interferon-alpha_and _ - beta by murine macrophages for induction of nitric_oxide synthase .
8645207	0	nitric_oxide	39,51	interferon-gamma	78,94	nitric oxide	interferon-gamma	MESH:D009569	15978(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|lipopolysaccharide lipopolysaccharide|amod|END_ENTITY	Regulation of the mouse inducible-type nitric_oxide synthase gene promoter by interferon-gamma , bacterial lipopolysaccharide and NG-monomethyl-L-arginine .
8727075	0	nitric_oxide	76,88	interferon-gamma	41,57	nitric oxide	interferon-gamma	MESH:D009569	3458	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of therapy with recombinant human interferon-gamma on the release of nitric_oxide by neutrophils and mononuclear cells from patients with chronic_granulomatous_disease .
8813644	0	nitric_oxide	75,87	interferon-gamma	45,61	nitric oxide	interferon-gamma	MESH:D009569	25712(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY induction|nmod|synthase induction|amod|END_ENTITY	Possible involvement of Janus kinase Jak2 in interferon-gamma induction of nitric_oxide synthase in rat glial cells .
8832969	0	nitric_oxide	14,26	interferon-gamma	116,132	nitric oxide	interferon-gamma	MESH:D009569	15978(Tax:10090)	Chemical	Gene	Generation|nmod|START_ENTITY impaired|nsubjpass|Generation impaired|nmod|mice mice|acl:relcl|lack lack|dobj|receptor receptor|amod|END_ENTITY	Generation of nitric_oxide and clearance of interferon-gamma after BCG infection are impaired in mice that lack the interferon-gamma receptor .
8946016	0	nitric_oxide	2,14	interferon-gamma	39,55	nitric oxide	interferon-gamma	MESH:D009569	3458	Chemical	Gene	bioassay|amod|START_ENTITY bioassay|nmod|END_ENTITY	A nitric_oxide production bioassay for interferon-gamma .
9010304	0	nitric_oxide	81,93	interferon-gamma	44,60	nitric oxide	interferon-gamma	MESH:D009569	15978(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY induction|nmod|production END_ENTITY|nmod|induction	Herpes_simplex_virus_type_2 synergizes with interferon-gamma in the induction of nitric_oxide production in mouse macrophages through autocrine secretion of tumour necrosis factor-alpha .
9161719	0	nitric_oxide	81,93	interferon-gamma	15,31	nitric oxide	interferon-gamma	MESH:D009569	3458	Chemical	Gene	production|amod|START_ENTITY regulation|nmod|production Interaction|nmod|regulation Interaction|nmod|END_ENTITY	Interaction of interferon-gamma and epidermal_growth_factor in the regulation of nitric_oxide production and cellular proliferation in a cultured murine mammary cell line , COMMA-D .
9166751	0	nitric_oxide	92,104	interferon-gamma	62,78	nitric oxide	interferon-gamma	MESH:D009569	3458	Chemical	Gene	synthase|amod|START_ENTITY induction|nmod|synthase induction|amod|END_ENTITY	Pretreatment of astrocytes with interferon-alpha/beta impairs interferon-gamma induction of nitric_oxide synthase .
9199670	0	nitric_oxide	10,22	interferon-gamma	78,94	nitric oxide	interferon-gamma	MESH:D009569	25712(Tax:10116)	Chemical	Gene	synthase|compound|START_ENTITY synthase|dep|induction induction|nmod|END_ENTITY	Inducible nitric_oxide synthase in the anterior pituitary gland : induction by interferon-gamma in a subpopulation of folliculostellate cells and in an unidentifiable population of non-hormone-secreting cells .
9203973	0	nitric_oxide	105,117	interferon-gamma	11,27	nitric oxide	interferon-gamma	MESH:D009569	15978(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY role|nmod|production role|nmod|factor-beta factor-beta|compound|END_ENTITY	A role for interferon-gamma and transforming growth factor-beta in erythroid cell-mediated regulation of nitric_oxide production in macrophages .
9227406	0	nitric_oxide	37,49	interferon-gamma	78,94	nitric oxide	interferon-gamma	MESH:D009569	25712(Tax:10116)	Chemical	Gene	Regulation|nmod|START_ENTITY synthase|nsubj|Regulation synthase|nmod|END_ENTITY	Regulation of inducible and neuronal nitric_oxide synthase gene expression by interferon-gamma and VIP .
9245708	0	nitric_oxide	82,94	interferon-gamma	112,128	nitric oxide	interferon-gamma	MESH:D009569	15978(Tax:10090)	Chemical	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Upstream NF-kappaB site is required for the maximal expression of mouse inducible nitric_oxide synthase gene in interferon-gamma plus lipopolysaccharide-induced RAW 264.7 macrophages .
9316638	0	nitric_oxide	33,45	interferon-gamma	106,122	nitric oxide	interferon-gamma	MESH:D009569	15978(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY inhibits|dobj|production inhibits|nmod|macrophages macrophages|acl|stimulated stimulated|nmod|END_ENTITY	Cryptococcus_neoformans inhibits nitric_oxide production by murine peritoneal macrophages stimulated with interferon-gamma and lipopolysaccharide .
9344498	0	nitric_oxide	68,80	interferon-gamma	8,24	nitric oxide	interferon-gamma	MESH:D009569	15978(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY Role|nmod|production Role|nmod|END_ENTITY	Role of interferon-gamma in the priming of decidual macrophages for nitric_oxide production and early pregnancy_loss .
7520478	0	nitric_oxide	55,67	interferon_regulatory_factor_1	8,38	nitric oxide	interferon regulatory factor 1	MESH:D009569	16362(Tax:10090)	Chemical	Gene	synthase|amod|START_ENTITY Role|nmod|synthase Role|nmod|END_ENTITY	Role of interferon_regulatory_factor_1 in induction of nitric_oxide synthase .
9120398	0	nitric_oxide	116,128	interferon_regulatory_factor_1	78,108	nitric oxide	interferon regulatory factor 1	MESH:D009569	16362(Tax:10090)	Chemical	Gene	synthesis|amod|START_ENTITY END_ENTITY|nmod|synthesis	Crucial role of interferon_consensus_sequence_binding_protein , but neither of interferon_regulatory_factor_1 nor of nitric_oxide synthesis for protection against murine listeriosis .
15209355	0	nitric_oxide	98,110	interleukin-1	50,63	nitric oxide	interleukin-1	MESH:D009569	3552	Chemical	Gene	generation|compound|START_ENTITY inhibition|nmod|generation inhibition|nsubj|N-palmitoylation N-palmitoylation|nmod|domain domain|nmod|affords affords|amod|END_ENTITY	N-palmitoylation of the radioprotective domain of interleukin-1 affords inhibition of LPS-induced nitric_oxide generation .
15899045	0	nitric_oxide	31,43	interleukin-1	123,136	nitric oxide	interleukin-1	MESH:D009569	3552	Chemical	Gene	type|amod|START_ENTITY involved|nmod|type activation|amod|involved activation|dep|effect effect|nmod|leptin leptin|nmod|END_ENTITY	Signalling pathway involved in nitric_oxide synthase type II activation in chondrocytes : synergistic effect of leptin with interleukin-1 .
8546706	0	nitric_oxide	69,81	interleukin-1	41,54	nitric oxide	interleukin-1	MESH:D009569	3552	Chemical	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	A redox-based mechanism for induction of interleukin-1 production by nitric_oxide in a human colonic epithelial cell line -LRB- HT29-Cl .16 E -RRB- .
10073964	0	nitric_oxide	94,106	interleukin-10	14,28	nitric oxide	interleukin-10	MESH:D009569	3586	Chemical	Gene	expression|amod|START_ENTITY inducible|dobj|expression relation|acl|inducible Expression|dep|relation Expression|nmod|END_ENTITY	Expression of interleukin-10 in advanced human atherosclerotic_plaques : relation to inducible nitric_oxide synthase expression and cell death .
10746547	0	nitric_oxide	18,30	interleukin-10	81,95	nitric oxide	interleukin-10	MESH:D009569	16153(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Essential role of nitric_oxide and interferon-gamma for tumor immunotherapy with interleukin-10 .
11930220	0	nitric_oxide	32,44	interleukin-10	14,28	nitric oxide	interleukin-10	MESH:D009569	25325(Tax:10116)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	-LSB- Influence of interleukin-10 on nitric_oxide / nitric_oxide synthase system of the aorta -RSB- .
11930220	0	nitric_oxide	46,58	interleukin-10	14,28	nitric oxide	interleukin-10	MESH:D009569	25325(Tax:10116)	Chemical	Gene	system|amod|START_ENTITY Influence|dep|system Influence|nmod|END_ENTITY	-LSB- Influence of interleukin-10 on nitric_oxide / nitric_oxide synthase system of the aorta -RSB- .
16714569	0	nitric_oxide	115,127	interleukin-10	15,29	nitric oxide	interleukin-10	MESH:D009569	16153(Tax:10090)	Chemical	Gene	control|nmod|START_ENTITY pulmonary_coccidioidomycosis|nmod|control resistance|nmod|pulmonary_coccidioidomycosis resistance|amod|END_ENTITY	High levels of interleukin-10 impair resistance to pulmonary_coccidioidomycosis in mice in part through control of nitric_oxide synthase 2 expression .
17148671	0	nitric_oxide	10,22	interleukin-10	103,117	nitric oxide	interleukin-10	MESH:D009569	16153(Tax:10090)	Chemical	Gene	synthesis|compound|START_ENTITY contributes|nsubj|synthesis contributes|xcomp|immunopathology immunopathology|nmod|myocarditis myocarditis|amod|attributable attributable|nmod|disorders disorders|amod|END_ENTITY	Sustained nitric_oxide synthesis contributes to immunopathology in ongoing myocarditis attributable to interleukin-10 disorders .
23563022	0	nitric_oxide	52,64	interleukin-10	16,30	nitric oxide	interleukin-10	MESH:D009569	3586	Chemical	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Effect of human interleukin-10 on the expression of nitric_oxide synthases in the MPTP-based model of Parkinson 's _ disease .
7688311	0	nitric_oxide	24,36	interleukin-10	115,129	nitric oxide	interleukin-10	MESH:D009569	3586	Chemical	Gene	production|compound|START_ENTITY Induction|nmod|production enhanced|nsubjpass|Induction enhanced|advcl|END_ENTITY	Induction of macrophage nitric_oxide production by interferon-gamma and tumor_necrosis_factor-alpha is enhanced by interleukin-10 .
9453622	0	nitric_oxide	23,35	interleukin-10	94,108	nitric oxide	interleukin-10	MESH:D009569	16153(Tax:10090)	Chemical	Gene	inhibition|amod|START_ENTITY effects|nmod|inhibition effects|dep|role role|nmod|END_ENTITY	Therapeutic effects of nitric_oxide inhibition during experimental fecal_peritonitis : role of interleukin-10 and monocyte_chemoattractant_protein_1 .
9852913	0	nitric_oxide	72,84	interleukin-10	28,42	nitric oxide	interleukin-10	MESH:D009569	25325(Tax:10116)	Chemical	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	Hybrid artificial lung with interleukin-10 and endothelial constitutive nitric_oxide synthase gene-transfected endothelial cells attenuates inflammatory reactions induced by cardiopulmonary bypass .
10823523	0	nitric_oxide	69,81	interleukin-10_or_transforming_growth_factor-beta	86,135	nitric oxide	interleukin-10 or transforming growth factor-beta	MESH:D009569	16153(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Septic mucosal intraepithelial lymphoid immune suppression : role for nitric_oxide not interleukin-10_or_transforming_growth_factor-beta .
11336918	0	nitric_oxide	28,40	interleukin-17	10,24	nitric oxide	interleukin-17	MESH:D009569	16171(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	Effect of interleukin-17 on nitric_oxide production and osteoclastic bone resorption : is there dependency on nuclear factor-kappaB and receptor activator of nuclear factor kappaB -LRB- RANK -RRB- / RANK ligand signaling ?
11070199	0	nitric_oxide	54,66	interleukin-1_beta	146,164	nitric oxide	interleukin-1 beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	synthase|compound|START_ENTITY immunoreactive|nmod|synthase immunoreactive|nmod|injection injection|nmod|END_ENTITY	Fos expression in neurons immunoreactive for neuronal nitric_oxide synthase in the rat paraventricular nucleus after intraperitoneal injection of interleukin-1_beta .
11247753	0	nitric_oxide	8,20	interleukin-1_beta	77,95	nitric oxide	interleukin-1 beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|response response|nmod|END_ENTITY	Role of nitric_oxide in the cerebrovascular and thermoregulatory response to interleukin-1_beta .
11798681	0	nitric_oxide	13,25	interleukin-1_beta	54,72	nitric oxide	interleukin-1 beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|change change|nmod|rat rat|amod|END_ENTITY	-LSB- The role of nitric_oxide on the functional change of interleukin-1_beta and interleukin-6 induced rat pancreatic islets of Langerhans -RSB- .
12068326	0	nitric_oxide	24,36	interleukin-1_beta	57,75	nitric oxide	interleukin-1 beta	MESH:D009569	100008990(Tax:9986)	Chemical	Gene	START_ENTITY|xcomp|induced induced|dep|END_ENTITY	Inhibition of inducible nitric_oxide synthase attenuates interleukin-1_beta induced vascular_hyporeactivity in the rabbit .
1280597	0	nitric_oxide	73,85	interleukin-1_beta	18,36	nitric oxide	interleukin-1 beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY inducer|nmod|synthase Synergism|appos|inducer Synergism|nmod|END_ENTITY	Synergism between interleukin-1_beta and interferon-gamma , an inducer of nitric_oxide synthase , in rat lung fibroblasts .
17286740	0	nitric_oxide	20,32	interleukin-1_beta	81,99	nitric oxide	interleukin-1 beta	MESH:D009569	16176(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY END_ENTITY|nsubj|production	Melatonin decreases nitric_oxide production and lipid peroxidation and increases interleukin-1_beta in the brain of mice infected by the Venezuelan_equine_encephalomyelitis_virus .
2265709	0	nitric_oxide	115,127	interleukin-1_beta	35,53	nitric oxide	interleukin-1 beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	mechanism|compound|START_ENTITY factor-alpha|nmod|mechanism necrosis|dobj|factor-alpha necrosis|nsubj|Inhibition Inhibition|nmod|secretion secretion|nmod|END_ENTITY	Inhibition of insulin secretion by interleukin-1_beta and tumour necrosis factor-alpha via an L-arginine-dependent nitric_oxide generating mechanism .
26335060	0	nitric_oxide	15,27	interleukin-1_beta	48,66	nitric oxide	interleukin-1 beta	MESH:D009569	3553	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|induction induction|nmod|END_ENTITY	Involvement of nitric_oxide in the induction of interleukin-1_beta in microglia .
7521071	0	nitric_oxide	59,71	interleukin-1_beta	32,50	nitric oxide	interleukin-1 beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|induced induced|amod|END_ENTITY	Cyclic nucleotide regulation of interleukin-1_beta induced nitric_oxide synthase expression in vascular smooth_muscle_cells .
7523451	0	nitric_oxide	110,122	interleukin-1_beta	70,88	nitric oxide	interleukin-1 beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	independent|advmod|START_ENTITY independent|nsubj|activities activities|nmod|END_ENTITY	The morphogenic/cytotoxic and prostaglandin-stimulating activities of interleukin-1_beta in the rat ovary are nitric_oxide independent .
7528993	0	nitric_oxide	24,36	interleukin-1_beta	54,72	nitric oxide	interleukin-1 beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|cells cells|amod|END_ENTITY	Regulation of inducible nitric_oxide synthase gene by interleukin-1_beta in rat vascular endothelial cells .
7532327	0	nitric_oxide	13,25	interleukin-1_beta	158,176	nitric oxide	interleukin-1 beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	inhibitor|amod|START_ENTITY Effects|nmod|inhibitor Effects|nmod|END_ENTITY	Effects of a nitric_oxide synthase inhibitor on vasopressin and atrial natriuretic hormone release , thermogenesis and cardiovascular functions in response to interleukin-1_beta in rats .
7536096	0	nitric_oxide	12,24	interleukin-1_beta	58,76	nitric oxide	interleukin-1 beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY induced|nsubj|role induced|nmod|factor-alpha factor-alpha|compound|END_ENTITY	The role of nitric_oxide in cardiac_depression induced by interleukin-1_beta and tumour necrosis factor-alpha .
7543244	0	nitric_oxide	54,66	interleukin-1_beta	90,108	nitric oxide	interleukin-1 beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	expression|compound|START_ENTITY necessary|nmod|expression necessary|advcl|END_ENTITY	Tyrosine kinase activation is necessary for inducible nitric_oxide synthase expression by interleukin-1_beta .
7628398	0	nitric_oxide	12,24	interleukin-1_beta	88,106	nitric oxide	interleukin-1 beta	MESH:D009569	3553	Chemical	Gene	adrenocorticotropin|amod|START_ENTITY Blockade|nmod|adrenocorticotropin Blockade|acl|released released|nmod|END_ENTITY	Blockade of nitric_oxide formation augments adrenocorticotropin released by blood-borne interleukin-1_beta : role of vasopressin , prostaglandins , and alpha 1-adrenergic receptors .
7768270	0	nitric_oxide	23,35	interleukin-1_beta	93,111	nitric oxide	interleukin-1 beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY Evidence|nmod|role induced|nsubj|Evidence induced|advcl|END_ENTITY	Evidence for a role of nitric_oxide in the corticotropin-releasing_factor release induced by interleukin-1_beta .
7774683	0	nitric_oxide	17,29	interleukin-1_beta	87,105	nitric oxide	interleukin-1 beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY cells|nsubj|synthesis cells|acl|induced induced|advcl|END_ENTITY	Ouabain enhances nitric_oxide synthesis in rat vascular smooth muscle cells induced by interleukin-1_beta .
8032008	0	nitric_oxide	68,80	interleukin-1_beta	41,59	nitric oxide	interleukin-1 beta	MESH:D009569	3553	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|activation activation|nmod|induced induced|amod|END_ENTITY	A role for tyrosine kinase activation in interleukin-1_beta induced nitric_oxide production in the insulin producing cell line RINm-5F .
8142651	0	nitric_oxide	35,47	interleukin-1_beta	61,79	nitric oxide	interleukin-1 beta	MESH:D009569	3553	Chemical	Gene	synthesis|amod|START_ENTITY induction|nmod|synthesis inhibit|dobj|induction inhibit|nmod|cells cells|amod|END_ENTITY	Platelets inhibit the induction of nitric_oxide synthesis by interleukin-1_beta in vascular smooth muscle cells .
8158253	0	nitric_oxide	23,35	interleukin-1_beta	105,123	nitric oxide	interleukin-1 beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	In the rat , endogenous nitric_oxide modulates the response of the hypothalamic-pituitary-adrenal_axis to interleukin-1_beta , vasopressin , and oxytocin .
8224196	0	nitric_oxide	11,23	interleukin-1_beta	35,53	nitric oxide	interleukin-1 beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	START_ENTITY|acl|induced induced|nmod|cells cells|amod|END_ENTITY	Endogenous nitric_oxide induced by interleukin-1_beta in rat islets of Langerhans and HIT-T15 cells causes significant DNA damage as measured by the ` comet ' assay .
8357951	0	nitric_oxide	52,64	interleukin-1_beta	75,93	nitric oxide	interleukin-1 beta	MESH:D009569	3553	Chemical	Gene	START_ENTITY|acl|evoked evoked|nmod|cells cells|amod|END_ENTITY	Eicosapentaenoic_acid potentiates the production of nitric_oxide evoked by interleukin-1_beta in cultured vascular smooth muscle cells .
8398001	0	nitric_oxide	23,35	interleukin-1_beta	86,104	nitric oxide	interleukin-1 beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	production|nmod|START_ENTITY production|nmod|END_ENTITY	Enhanced production of nitric_oxide in aortae from spontaneously hypertensive rats by interleukin-1_beta .
8447474	0	nitric_oxide	33,45	interleukin-1_beta	59,77	nitric oxide	interleukin-1 beta	MESH:D009569	3553	Chemical	Gene	synthesis|amod|START_ENTITY induction|nmod|synthesis potentiates|dobj|induction potentiates|nmod|cells cells|amod|END_ENTITY	Plasmin potentiates induction of nitric_oxide synthesis by interleukin-1_beta in vascular smooth muscle cells .
8575535	0	nitric_oxide	21,33	interleukin-1_beta	91,109	nitric oxide	interleukin-1 beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY inhibits|dobj|synthesis inhibits|dep|cells cells|acl|induced induced|advcl|END_ENTITY	Aldosterone inhibits nitric_oxide synthesis in rat vascular smooth muscle cells induced by interleukin-1_beta .
8733293	0	nitric_oxide	14,26	interleukin-1_beta	116,134	nitric oxide	interleukin-1 beta	MESH:D009569	100008990(Tax:9986)	Chemical	Gene	synthase|amod|START_ENTITY Inhibition|nmod|synthase attenuates|nsubj|Inhibition attenuates|dobj|fever fever|amod|END_ENTITY	Inhibition of nitric_oxide synthase or cyclo-oxygenase pathways in organum vasculosum laminae terminalis attenuates interleukin-1_beta fever in rabbits .
8776577	0	nitric_oxide	32,44	interleukin-1_beta	65,83	nitric oxide	interleukin-1 beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY synthase|nsubj|inhibition synthase|nmod|production production|amod|END_ENTITY	Gradual inhibition of inducible nitric_oxide synthase but not of interleukin-1_beta production in rat microglial cells of endotoxin-treated mixed glial cell cultures .
8884240	0	nitric_oxide	103,115	interleukin-1_beta	75,93	nitric oxide	interleukin-1 beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY Regulation|dep|role Regulation|nmod|growth growth|nmod|cells cells|nmod|rats rats|nmod|END_ENTITY	Regulation of growth of cultured smooth muscle cells from diabetic rats by interleukin-1_beta : role of nitric_oxide .
9259476	0	nitric_oxide	104,116	interleukin-1_beta	45,63	nitric oxide	interleukin-1 beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	exogenous|nmod|START_ENTITY exogenous|amod|END_ENTITY	The dominant role of exogenous or endogenous interleukin-1_beta on expression and activity of inducible nitric_oxide synthase in rat microvascular brain endothelial cells .
10414975	0	nitric_oxide	35,47	interleukin-1beta	89,106	nitric oxide	interleukin-1beta	MESH:D009569	3553	Chemical	Gene	expression|compound|START_ENTITY expression|dep|involvement involvement|nmod|production production|amod|END_ENTITY	Gp-41-mediated astrocyte inducible nitric_oxide synthase mRNA expression : involvement of interleukin-1beta production by microglia .
10489101	0	nitric_oxide	71,83	interleukin-1beta	32,49	nitric oxide	interleukin-1beta	MESH:D009569	3553	Chemical	Gene	synthesis|amod|START_ENTITY mediated|nmod|synthesis mediated|nsubj|effect effect|nmod|erythropoietin erythropoietin|nmod|END_ENTITY	The effect of erythropoietin on interleukin-1beta mediated increase in nitric_oxide synthesis in vascular smooth muscle cells .
10505651	0	nitric_oxide	68,80	interleukin-1beta	40,57	nitric oxide	interleukin-1beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	START_ENTITY|amod|dependent dependent|amod|END_ENTITY	Astrocytes rather than neurones mediate interleukin-1beta dependent nitric_oxide and superoxide radical release in primary hypothalamic rat cell cultures .
10650342	0	nitric_oxide	72,84	interleukin-1beta	31,48	nitric oxide	interleukin-1beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY responses|dep|role responses|nmod|END_ENTITY	Cardiorespiratory responses to interleukin-1beta in adult rats : role of nitric_oxide , eicosanoids and glucocorticoids .
10775561	0	nitric_oxide	63,75	interleukin-1beta	32,49	nitric oxide	interleukin-1beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY induction|nmod|synthase induction|amod|END_ENTITY	N-Acetyl-L-cysteine potentiates interleukin-1beta induction of nitric_oxide synthase : role of p44/42 mitogen-activated protein kinases .
10793263	0	nitric_oxide	59,71	interleukin-1beta	116,133	nitric oxide	interleukin-1beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	promoter|amod|START_ENTITY element|nmod|promoter mediates|nsubj|element mediates|nmod|cells cells|amod|END_ENTITY	A reverse nuclear factor-kappaB element in the rat type II nitric_oxide synthase promoter mediates the induction by interleukin-1beta and interferon-gamma in rat aortic smooth muscle cells .
11682145	0	nitric_oxide	33,45	interleukin-1beta	15,32	nitric oxide	interleukin-1beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Involvement Involvement|nmod|/ /|amod|END_ENTITY	Involvement of interleukin-1beta / nitric_oxide pathway in the postischemic_impairment of long-term potentiation of the rat hippocampus .
11936556	0	nitric_oxide	12,24	interleukin-1beta	86,103	nitric oxide	interleukin-1beta	MESH:D009569	3553	Chemical	Gene	Role|nmod|START_ENTITY cyclic_GMP|dep|Role cyclic_GMP|appos|signaling signaling|nmod|effect effect|nmod|END_ENTITY	Role of the nitric_oxide / cyclic_GMP / Ca2 + signaling pathway in the pyrogenic effect of interleukin-1beta .
12055140	0	nitric_oxide	64,76	interleukin-1beta	33,50	nitric oxide	interleukin-1beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY induction|nmod|synthase induction|amod|END_ENTITY	Docosahexaenoic_acid potentiates interleukin-1beta induction of nitric_oxide synthase through mechanism involving p44/42 MAPK activation in rat vascular smooth muscle cells .
12154205	0	nitric_oxide	40,52	interleukin-1beta	83,100	nitric oxide	interleukin-1beta	MESH:D009569	3553	Chemical	Gene	production|amod|START_ENTITY potently|nsubj|production potently|nmod|END_ENTITY	Tumour necrosis factor alpha stimulates nitric_oxide production more potently than interleukin-1beta in porcine articular chondrocytes .
12627879	0	nitric_oxide	31,43	interleukin-1beta	94,111	nitric oxide	interleukin-1beta	MESH:D009569	3553	Chemical	Gene	production|amod|START_ENTITY production|nmod|cells cells|amod|END_ENTITY	Lipoxygenase products regulate nitric_oxide and inducible_nitric_oxide_synthase production in interleukin-1beta stimulated vascular smooth muscle cells .
12823994	0	nitric_oxide	13,25	interleukin-1beta	74,91	nitric oxide	interleukin-1beta	MESH:D009569	100008990(Tax:9986)	Chemical	Gene	synthase|amod|START_ENTITY Induction|nmod|synthase Induction|nmod|cells cells|amod|END_ENTITY	Induction of nitric_oxide synthase and over-production of nitric_oxide by interleukin-1beta in cultured lacrimal gland acinar cells .
12823994	0	nitric_oxide	58,70	interleukin-1beta	74,91	nitric oxide	interleukin-1beta	MESH:D009569	100008990(Tax:9986)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|cells cells|amod|END_ENTITY	Induction of nitric_oxide synthase and over-production of nitric_oxide by interleukin-1beta in cultured lacrimal gland acinar cells .
12960105	0	nitric_oxide	97,109	interleukin-1beta	47,64	nitric oxide	interleukin-1beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	pathway|amod|START_ENTITY related|nmod|pathway related|nsubjpass|apoptosis apoptosis|acl|triggered triggered|advcl|END_ENTITY	Islet beta-cell apoptosis triggered in vivo by interleukin-1beta is not related to the inducible nitric_oxide synthase pathway : evidence for mitochondrial function impairment and lipoperoxidation .
15036398	0	nitric_oxide	26,38	interleukin-1beta	136,153	nitric oxide	interleukin-1beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	production|nmod|START_ENTITY induced|nsubj|production induced|nmod|END_ENTITY	Exaggerated production of nitric_oxide -LRB- NO -RRB- and increases in inducible_NO-synthase mRNA levels induced by the pro-inflammatory cytokine interleukin-1beta in vascular smooth muscle cells of elderly rats .
15223378	0	nitric_oxide	98,110	interleukin-1beta	12,29	nitric oxide	interleukin-1beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY activating|dobj|expression induces|advcl|activating induces|nsubj|administration administration|amod|END_ENTITY	Intrathecal interleukin-1beta administration induces thermal hyperalgesia by activating inducible nitric_oxide synthase expression in the rat spinal cord .
15544852	0	nitric_oxide	28,40	interleukin-1beta	131,148	nitric oxide	interleukin-1beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	precursor|amod|START_ENTITY administration|nmod|precursor abolishes|nsubj|administration abolishes|dep|induced induced|nmod|END_ENTITY	Central administration of a nitric_oxide precursor abolishes both the hypothalamic serotonin release and the hypophagia induced by interleukin-1beta in obese Zucker rats .
16214938	0	nitric_oxide	172,184	interleukin-1beta	70,87	nitric oxide	interleukin-1beta	MESH:D009569	3553	Chemical	Gene	production|amod|START_ENTITY independent|nmod|production apoptosis|amod|independent activation|nsubj|apoptosis activation|dep|protects protects|nmod|necrosis necrosis|amod|END_ENTITY	STAT5 activation by human GH protects insulin-producing cells against interleukin-1beta , interferon-gamma and tumour necrosis factor-alpha-induced apoptosis independent of nitric_oxide production .
16245181	0	nitric_oxide	101,113	interleukin-1beta	69,86	nitric oxide	interleukin-1beta	MESH:D009569	16176(Tax:10090)	Chemical	Gene	synthase|amod|START_ENTITY synthase|amod|END_ENTITY	Surfactin C inhibits the lipopolysaccharide-induced transcription of interleukin-1beta and inducible nitric_oxide synthase and nitric_oxide production in murine RAW 264.7 cells .
16516485	0	nitric_oxide	20,32	interleukin-1beta	115,132	nitric oxide	interleukin-1beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	synthesis|compound|START_ENTITY Inhibition|nmod|synthesis enhances|nsubj|Inhibition enhances|dobj|effect effect|nmod|END_ENTITY	Inhibition of brain nitric_oxide synthesis enhances and prolongs the hypertensive effect of centrally administered interleukin-1beta in rats .
18051719	0	nitric_oxide	33,45	interleukin-1beta	12,29	nitric oxide	interleukin-1beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	-LSB- Effects of interleukin-1beta on nitric_oxide production and ATP synthesis in rat surplus hepatocytes after partial hepatectomy -RSB- .
18171908	0	nitric_oxide	33,45	interleukin-1beta	68,85	nitric oxide	interleukin-1beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY production|acl|induced induced|nmod|cells cells|amod|END_ENTITY	Sphingosine_1-phosphate inhibits nitric_oxide production induced by interleukin-1beta in rat vascular smooth muscle cells .
19595066	0	nitric_oxide	46,58	interleukin-1beta	20,37	nitric oxide	interleukin-1beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|induced induced|amod|END_ENTITY	-LSB- Glutamine inhibits interleukin-1beta induced nitric_oxide production and inducible nitric_oxide synthase expression : experiment with cultured rat hepatocytes -RSB- .
19595066	0	nitric_oxide	84,96	interleukin-1beta	20,37	nitric oxide	interleukin-1beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	expression|compound|START_ENTITY nitric_oxide|dobj|expression nitric_oxide|nsubj|induced induced|amod|END_ENTITY	-LSB- Glutamine inhibits interleukin-1beta induced nitric_oxide production and inducible nitric_oxide synthase expression : experiment with cultured rat hepatocytes -RSB- .
8603098	0	nitric_oxide	95,107	interleukin-1beta	35,52	nitric oxide	interleukin-1beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|Regulation Regulation|nmod|metabolism metabolism|nmod|END_ENTITY	Regulation of energy metabolism by interleukin-1beta , but not by interleukin-6 , is mediated by nitric_oxide in primary cultured rat hepatocytes .
8613229	0	nitric_oxide	46,58	interleukin-1beta	14,31	nitric oxide	interleukin-1beta	MESH:D009569	16176(Tax:10090)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Mechanisms of interleukin-1beta regulation of nitric_oxide synthase in cardiac myocytes .
9021956	0	nitric_oxide	54,66	interleukin-1beta	88,105	nitric oxide	interleukin-1beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	formation|amod|START_ENTITY formation|acl|induced induced|advcl|END_ENTITY	The anti-inflammatory drug sodium_salicylate inhibits nitric_oxide formation induced by interleukin-1beta at a translational step , but not at a transcriptional step , in hepatocytes .
9065483	0	nitric_oxide	52,64	interleukin-1beta	126,143	nitric oxide	interleukin-1beta	MESH:D009569	3553	Chemical	Gene	stimulated|nsubj|START_ENTITY stimulated|advcl|END_ENTITY	p38_mitogen-activated_protein_kinase down-regulates nitric_oxide and up-regulates prostaglandin_E2 biosynthesis stimulated by interleukin-1beta .
9386181	0	nitric_oxide	36,48	interleukin-1beta	125,142	nitric oxide	interleukin-1beta	MESH:D009569	396565(Tax:9823)	Chemical	Gene	synthase|compound|START_ENTITY role|nmod|synthase induced|nsubj|role induced|advcl|END_ENTITY	Vasculoprotective role of inducible nitric_oxide synthase at inflammatory coronary lesions induced by chronic treatment with interleukin-1beta in pigs in vivo .
9825753	0	nitric_oxide	24,36	interleukin-1beta	51,68	nitric oxide	interleukin-1beta	MESH:D009569	3553	Chemical	Gene	production|nmod|START_ENTITY stimulated|nsubj|production stimulated|nmod|cells cells|amod|END_ENTITY	Increased production of nitric_oxide stimulated by interleukin-1beta in peripheral blood mononuclear cells in patients with systemic_sclerosis .
12399127	0	nitric_oxide	35,47	interleukin-2	13,26	nitric oxide	interleukin-2	MESH:D009569	3558	Chemical	Gene	production|amod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Intrapleural interleukin-2 induces nitric_oxide production in pleural_effusions from malignant_mesothelioma : a possible mechanism of interleukin-2-mediated cytotoxicity ?
12895141	0	nitric_oxide	55,67	interleukin-2	131,144	nitric oxide	interleukin-2	MESH:D009569	443401(Tax:9940)	Chemical	Gene	scavenger|amod|START_ENTITY conjugate|appos|scavenger decreases|nsubj|conjugate decreases|dobj|hypotension hypotension|acl|associated associated|nmod|therapy therapy|compound|END_ENTITY	Pyridoxalated haemoglobin polyoxyethylene conjugate , a nitric_oxide scavenger , decreases dose-limiting hypotension associated with interleukin-2 -LRB- IL-2 -RRB- therapy .
1541678	0	nitric_oxide	32,44	interleukin-2	93,106	nitric oxide	interleukin-2	MESH:D009569	3558	Chemical	Gene	Evidence|nmod|START_ENTITY synthesis|nsubj|Evidence synthesis|nmod|patients patients|acl|receiving receiving|dobj|therapy therapy|compound|END_ENTITY	Evidence for cytokine-inducible nitric_oxide synthesis from L-arginine in patients receiving interleukin-2 therapy .
15789772	0	nitric_oxide	16,28	interleukin-2	46,59	nitric oxide	interleukin-2	MESH:D009569	116562(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|effect effect|nmod|END_ENTITY	-LSB- Involvement of nitric_oxide in the effect of interleukin-2 on the contractility of rat ventricular cardiomyocytes -RSB- .
16865093	0	nitric_oxide	93,105	interleukin-2	27,40	nitric oxide	interleukin-2	MESH:D009569	16183(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY migration|dep|role inhibits|dobj|migration inhibits|nsubj|administration administration|nmod|END_ENTITY	Systemic administration of interleukin-2 inhibits inflammatory neutrophil migration : role of nitric_oxide .
24304013	0	nitric_oxide	13,25	interleukin-2	60,73	nitric oxide	interleukin-2	MESH:D009569	16183(Tax:10090)	Chemical	Gene	Reduction|nmod|START_ENTITY Reduction|dep|NG-monomethyl_arginine NG-monomethyl_arginine|nmod|END_ENTITY	Reduction of nitric_oxide with L - / NG-monomethyl_arginine in interleukin-2 and anti-CD3 monoclonal antibody combination therapy .
8050458	0	nitric_oxide	36,48	interleukin-2	127,140	nitric oxide	interleukin-2	MESH:D009569	3558	Chemical	Gene	Association|nmod|START_ENTITY Association|acl|treated treated|nmod|END_ENTITY	Association between biosynthesis of nitric_oxide and changes in immunological and vascular parameters in patients treated with interleukin-2 .
8854644	0	nitric_oxide	11,23	interleukin-2	80,93	nitric oxide	interleukin-2	MESH:D009569	16183(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY synthesis|nsubj|Effects synthesis|nmod|treatment treatment|amod|END_ENTITY	Effects of nitric_oxide -LRB- NO -RRB- synthesis inhibition on antitumor responses during interleukin-2 -LRB- IL-2 -RRB- treatment of mice .
9010449	0	nitric_oxide	29,41	interleukin-2	124,137	nitric oxide	interleukin-2	MESH:D009569	16183(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|pathogenesis pathogenesis|nmod|capillary_leak_syndrome capillary_leak_syndrome|acl|resulting resulting|nmod|therapy therapy|compound|END_ENTITY	The role of active inducible nitric_oxide synthase expression in the pathogenesis of capillary_leak_syndrome resulting from interleukin-2 therapy in mice .
9384490	0	nitric_oxide	15,27	interleukin-2	65,78	nitric oxide	interleukin-2	MESH:D009569	3558	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|inhibition inhibition|nmod|angiogenesis angiogenesis|nmod|END_ENTITY	Involvement of nitric_oxide in the inhibition of angiogenesis by interleukin-2 .
9544427	0	nitric_oxide	12,24	interleukin-2	28,41	nitric oxide	interleukin-2	MESH:D009569	3558	Chemical	Gene	START_ENTITY|nmod|therapy therapy|compound|END_ENTITY	The role of nitric_oxide in interleukin-2 therapy induced hypotension .
10233688	0	nitric_oxide	122,134	interleukin-4	22,35	nitric oxide	interleukin-4	MESH:D009569	287287(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY effects|dep|role effects|nmod|END_ENTITY	Reciprocal effects of interleukin-4 and interferon-gamma on immunoglobulin E-mediated mast cell degranulation : a role for nitric_oxide but not peroxynitrite or cyclic_guanosine_monophosphate .
10669116	0	nitric_oxide	60,72	interleukin-4	24,37	nitric oxide	interleukin-4	MESH:D009569	16189(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY effects|nmod|production effects|nmod|END_ENTITY	Differential effects of interleukin-4 and interleukin-10 on nitric_oxide production by murine macrophages .
12845750	0	nitric_oxide	21,33	interleukin-4	55,68	nitric oxide	interleukin-4	MESH:D009569	287287(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of intrinsic nitric_oxide on the expression of interleukin-4 and IFN-gamma mRNA in the bronchial and lung tissues of sensitized rats .
17308792	0	nitric_oxide	103,115	interleukin-4	23,36	nitric oxide	interleukin-4	MESH:D009569	16189(Tax:10090)	Chemical	Gene	mice|compound|START_ENTITY results|nmod|mice results|nmod|production production|compound|END_ENTITY	Preliminary results on interleukin-4 and interleukin-10 cytokine production in malnourished , inducible nitric_oxide synthase-deficient mice with schistosomiasis_mansoni_infection .
18182309	0	nitric_oxide	53,65	interleukin-4	29,42	nitric oxide	interleukin-4	MESH:D009569	287287(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY decreases|dobj|production decreases|nsubj|injection injection|nmod|END_ENTITY	Intra-articular injection of interleukin-4 decreases nitric_oxide production by chondrocytes and ameliorates subsequent destruction of cartilage in instability-induced osteoarthritis in rat knee joints .
18475707	0	nitric_oxide	56,68	interleukin-4	20,33	nitric oxide	interleukin-4	MESH:D009569	16189(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY effects|nmod|production effects|nmod|END_ENTITY	Opposite effects of interleukin-4 and interleukin-10 on nitric_oxide production in murine macrophages .
7507968	0	nitric_oxide	28,40	interleukin-4	64,77	nitric oxide	interleukin-4	MESH:D009569	16189(Tax:10090)	Chemical	Gene	suppression|nmod|START_ENTITY Mechanism|nmod|suppression synthase|nsubj|Mechanism synthase|nmod|END_ENTITY	Mechanism of suppression of nitric_oxide synthase expression by interleukin-4 in primary mouse macrophages .
7523136	0	nitric_oxide	14,26	interleukin-4	40,53	nitric oxide	interleukin-4	MESH:D009569	16189(Tax:10090)	Chemical	Gene	synthesis|amod|START_ENTITY synthesis|nmod|END_ENTITY	Inhibition of nitric_oxide synthesis by interleukin-4 may involve inhibiting the activation of protein_kinase_C epsilon .
7882138	0	nitric_oxide	44,56	interleukin-4	9,22	nitric oxide	interleukin-4	MESH:D009569	3565	Chemical	Gene	production|amod|START_ENTITY regulation|nmod|production END_ENTITY|nmod|regulation	-LSB- Role of interleukin-4 in the regulation of nitric_oxide production by normal human monocytes -RSB- .
10233692	0	nitric_oxide	8,20	interleukin-6	133,146	nitric oxide	interleukin-6	MESH:D009569	16193(Tax:10090)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|effects effects|nmod|macrophages macrophages|amod|calcitonin_gene-related_peptide calcitonin_gene-related_peptide|nmod|release release|amod|END_ENTITY	Role of nitric_oxide and prostaglandins in the potentiating effects of calcitonin_gene-related_peptide on lipopolysaccharide-induced interleukin-6 release from mouse peritoneal macrophages .
10362412	0	nitric_oxide	14,26	interleukin-6	84,97	nitric oxide	interleukin-6	MESH:D009569	3569	Chemical	Gene	inhibitor|amod|START_ENTITY Effect|nmod|inhibitor monomethylarginine|nsubj|Effect monomethylarginine|nmod|accumulation accumulation|nmod|END_ENTITY	Effect of the nitric_oxide inhibitor , L-N -LRB- G -RRB- - monomethylarginine , on accumulation of interleukin-6 and interleukin-8 , and nuclear factor-kappaB activity in a human endothelial cell line .
14645573	0	nitric_oxide	164,176	interleukin-6	139,152	nitric oxide	interleukin-6	MESH:D009569	16193(Tax:10090)	Chemical	Gene	Fas_ligand|compound|START_ENTITY Fas_ligand|amod|END_ENTITY	Protection against murine leukemia virus-induced spongiform myeloencephalopathy in mice overexpressing Bcl-2 but not in mice deficient for interleukin-6 , inducible nitric_oxide synthetase , ICE , Fas , Fas_ligand , or TNF-R1 genes .
15191513	0	nitric_oxide	47,59	interleukin-6	107,120	nitric oxide	interleukin-6	MESH:D009569	3569	Chemical	Gene	synthase|compound|START_ENTITY expression|nmod|synthase Chronic_gastritis|nmod|expression associated|nsubjpass|Chronic_gastritis associated|nmod|expression expression|nmod|END_ENTITY	Chronic_gastritis with expression of inducible nitric_oxide synthase is associated with high expression of interleukin-6 and hypergastrinaemia .
17323195	0	nitric_oxide	93,105	interleukin-6	29,42	nitric oxide	interleukin-6	MESH:D009569	24498(Tax:10116)	Chemical	Gene	reperfusion|nmod|START_ENTITY release|dep|reperfusion release|amod|END_ENTITY	Alpha-lactalbumin suppresses interleukin-6 release after intestinal_ischemia / reperfusion via nitric_oxide in rats .
19010201	0	nitric_oxide	86,98	interleukin-6	12,25	nitric oxide	interleukin-6	MESH:D009569	3569	Chemical	Gene	administration|amod|START_ENTITY correlation|nmod|administration Analysis|dep|correlation Analysis|acl|END_ENTITY	Analysis of interleukin-6 and interleukin-8 in lung transplantation : correlation with nitric_oxide administration .
7514114	0	nitric_oxide	13,25	interleukin-6	100,113	nitric oxide	interleukin-6	MESH:D009569	16193(Tax:10090)	Chemical	Gene	synthase|amod|START_ENTITY Induction|nmod|synthase Induction|dep|effect effect|nmod|production production|amod|END_ENTITY	Induction of nitric_oxide synthase in subsets of murine pulmonary fibroblasts : effect on fibroblast interleukin-6 production .
9488425	0	nitric_oxide	36,48	interleukin-6	8,21	nitric oxide	interleukin-6	MESH:D009569	16193(Tax:10090)	Chemical	Gene	synthase|amod|START_ENTITY synthase|amod|END_ENTITY	Neither interleukin-6 nor inducible nitric_oxide synthase is required for clearance of Chlamydia_trachomatis from the murine genital tract epithelium .
10353264	0	nitric_oxide	86,98	interleukin-8	46,59	nitric oxide	interleukin-8	MESH:D009569	3576	Chemical	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|END_ENTITY	Up-regulation of interleukin-1beta-stimulated interleukin-8 in human keratinocytes by nitric_oxide .
10695614	0	nitric_oxide	44,56	interleukin-8	16,29	nitric oxide	interleukin-8	MESH:D009569	3576	Chemical	Gene	synthase|amod|START_ENTITY synthase|amod|END_ENTITY	Coexpression of interleukin-8 and inducible nitric_oxide synthase in gastric mucosa infected with cagA + Helicobacter_pylori .
11506748	0	nitric_oxide	42,54	interleukin-8	14,27	nitric oxide	interleukin-8	MESH:D009569	3576	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of interleukin-8 expression by nitric_oxide in human pancreatic_adenocarcinoma .
11521757	0	nitric_oxide	11,23	interleukin-8	91,104	nitric oxide	interleukin-8	MESH:D009569	3576	Chemical	Gene	inhibits|advmod|START_ENTITY inhibits|advcl|modulate modulate|dobj|release release|amod|END_ENTITY	Endogenous nitric_oxide inhibits neutrophil adherence to lung epithelial cells to modulate interleukin-8 release .
12096924	0	nitric_oxide	60,72	interleukin-8	20,33	nitric oxide	interleukin-8	MESH:D009569	3576	Chemical	Gene	production|amod|START_ENTITY production|amod|END_ENTITY	Glutamine decreases interleukin-8 and interleukin-6 but not nitric_oxide and prostaglandins_e -LRB- 2 -RRB- production by human gut in-vitro .
15949732	0	nitric_oxide	30,42	interleukin-8	46,59	nitric oxide	interleukin-8	MESH:D009569	100620730	Chemical	Gene	START_ENTITY|nmod|release release|amod|END_ENTITY	Effects of short-term inhaled nitric_oxide on interleukin-8 release after single-lung transplantation in pigs .
9215025	0	nitric_oxide	20,32	interleukin-8	51,64	nitric oxide	interleukin-8	MESH:D009569	3576	Chemical	Gene	START_ENTITY|nmod|leucocytes leucocytes|amod|END_ENTITY	Effect of exogenous nitric_oxide and superoxide on interleukin-8 from human polymorphonuclear leucocytes .
9350989	0	nitric_oxide	33,45	interleukin-8	70,83	nitric oxide	interleukin-8	MESH:D009569	3576	Chemical	Gene	enhancement|amod|START_ENTITY enhancement|nmod|secretion secretion|amod|END_ENTITY	Intracellular Ca2 + dependence of nitric_oxide mediated enhancement of interleukin-8 secretion in human endothelial cells .
9459261	0	nitric_oxide	15,27	interleukin-8	49,62	nitric oxide	interleukin-8	MESH:D009569	3576	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of nitric_oxide and peroxynitrite on interleukin-8 and elastase from lipopolysaccharide-stimulated whole blood .
16317388	0	nitric_oxide	26,38	interleukin_18	8,22	nitric oxide	interleukin 18	MESH:D009569	16173(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	Role of interleukin_18 in nitric_oxide production and pancreatic_damage during acute_pancreatitis .
7506668	0	nitric_oxide	64,76	interleukin_1_beta	32,50	nitric oxide	interleukin 1 beta	MESH:D009569	3553	Chemical	Gene	synthase|amod|START_ENTITY induction|nmod|synthase induction|amod|END_ENTITY	Cyclosporin derivatives inhibit interleukin_1_beta induction of nitric_oxide synthase in renal mesangial cells .
7526844	0	nitric_oxide	101,113	interleukin_1_beta	69,87	nitric oxide	interleukin 1 beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY induction|nmod|synthase induction|amod|END_ENTITY	Possible role of protein kinase C-epsilon isoenzyme in inhibition of interleukin_1_beta induction of nitric_oxide synthase in rat renal mesangial cells .
7528007	0	nitric_oxide	80,92	interleukin_1_beta	37,55	nitric oxide	interleukin 1 beta	MESH:D009569	3553	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Dexamethasone differentially affects interleukin_1_beta - and cyclic_AMP-induced nitric_oxide synthase mRNA expression in renal mesangial cells .
7615197	0	nitric_oxide	106,118	interleukin_1_beta	78,96	nitric oxide	interleukin 1 beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY Implication|dep|role Implication|nmod|receptors receptors|nmod|colonic_hypersecretion colonic_hypersecretion|acl|induced induced|nmod|END_ENTITY	Implication of NK1 and NK2 receptors in rat colonic_hypersecretion induced by interleukin_1_beta : role of nitric_oxide .
8635652	0	nitric_oxide	129,141	interleukin_1_beta	65,83	nitric oxide	interleukin 1 beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	synthesis|compound|START_ENTITY association|nmod|synthesis differences|dep|association differences|nmod|sensitivity sensitivity|nmod|beta-cells beta-cells|nmod|END_ENTITY	Strain-dependent differences in sensitivity of rat beta-cells to interleukin_1_beta in vitro and in vivo : association with islet nitric_oxide synthesis .
9325192	0	nitric_oxide	25,37	interleukin_1_beta	112,130	nitric oxide	interleukin 1 beta	MESH:D009569	3553	Chemical	Gene	cells|amod|START_ENTITY induction|nmod|cells modulated|nsubjpass|induction modulated|nmod|END_ENTITY	Spontaneous induction of nitric_oxide - and prostaglandin_E2-release by hypoxic astroglial cells is modulated by interleukin_1_beta .
10587350	0	nitric_oxide	70,82	interleukin_1beta	48,65	nitric oxide	interleukin 1beta	MESH:D009569	3553	Chemical	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	Methylation-dependent gene silencing induced by interleukin_1beta via nitric_oxide production .
9389745	0	nitric_oxide	120,132	interleukin_1beta	84,101	nitric oxide	interleukin 1beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Platelet-derived growth factor and fibroblast growth factor differentially regulate interleukin_1beta - and cAMP-induced nitric_oxide synthase expression in rat renal mesangial cells .
9696008	0	nitric_oxide	90,102	interleukin_1beta	25,42	nitric oxide	interleukin 1beta	MESH:D009569	24494(Tax:10116)	Chemical	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|effect effect|nmod|END_ENTITY	The inhibitory effect of interleukin_1beta on rat hepatocyte DNA synthesis is mediated by nitric_oxide .
9858439	0	nitric_oxide	71,83	interleukin_1beta	32,49	nitric oxide	interleukin 1beta	MESH:D009569	3553	Chemical	Gene	level|compound|START_ENTITY level|amod|END_ENTITY	Diacerhein and rhein reduce the interleukin_1beta stimulated inducible nitric_oxide synthesis level and activity while stimulating cyclooxygenase-2 synthesis in human osteoarthritic chondrocytes .
22015071	0	nitric_oxide	21,33	interphotoreceptor_retinoid-binding_protein	110,153	nitric oxide	interphotoreceptor retinoid-binding protein	MESH:D009569	24711(Tax:10116)	Chemical	Gene	involvement|nmod|START_ENTITY induced|nsubj|involvement induced|nmod|END_ENTITY	Early involvement of nitric_oxide in mechanisms of pathogenesis of experimental autoimmune_uveitis induced by interphotoreceptor_retinoid-binding_protein -LRB- IRBP -RRB- .
10823926	0	nitric_oxide	64,76	iron_regulatory_protein_1	19,44	nitric oxide	iron regulatory protein 1	MESH:D009569	11428(Tax:10090)	Chemical	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|nmod|expression expression|amod|END_ENTITY	Down-regulation of iron_regulatory_protein_1 gene expression by nitric_oxide .
12039960	0	nitric_oxide	75,87	iron_regulatory_protein_1	25,50	nitric oxide	iron regulatory protein 1	MESH:D009569	48	Chemical	Gene	removal|amod|START_ENTITY RNA|nmod|removal RNA|dobj|END_ENTITY	Recycling of RNA binding iron_regulatory_protein_1 into an aconitase after nitric_oxide removal depends on mitochondrial ATP .
15629469	0	nitric_oxide	63,75	iron_regulatory_protein_1	13,38	nitric oxide	iron regulatory protein 1	MESH:D009569	11428(Tax:10090)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Induction of iron_regulatory_protein_1 RNA-binding activity by nitric_oxide is associated with a concomitant increase in the labile_iron_pool : implications for DNA damage .
16886906	0	nitric_oxide	95,107	iron_regulatory_protein_1	50,75	nitric oxide	iron regulatory protein 1	MESH:D009569	11428(Tax:10090)	Chemical	Gene	involved|nmod|START_ENTITY involved|nmod|down-regulation down-regulation|nmod|expression expression|amod|END_ENTITY	STAT5 proteins are involved in down-regulation of iron_regulatory_protein_1 gene expression by nitric_oxide .
10556640	0	nitric_oxide	60,72	leptin	11,17	nitric oxide	leptin	MESH:D009569	25608(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY END_ENTITY|nmod|inhibition	Effects of leptin on fasting-induced inhibition of neuronal nitric_oxide synthase mRNA in the paraventricular and supraoptic nuclei of rats .
10873674	0	nitric_oxide	15,27	leptin	76,82	nitric oxide	leptin	MESH:D009569	3952	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of nitric_oxide in endothelium-dependent arterial relaxation by leptin .
12226143	0	nitric_oxide	33,45	leptin	6,12	nitric oxide	leptin	MESH:D009569	25608(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Human leptin stimulates systemic nitric_oxide production in the rat .
213126	0	nitric_oxide	19,31	lipoxygenase-1	45,59	nitric oxide	lipoxygenase-1	MESH:D009569	547923(Tax:3847)	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	The interaction of nitric_oxide with soybean lipoxygenase-1 .
23115015	0	nitric_oxide	63,75	maspin	42,48	nitric oxide	maspin	MESH:D009569	5268	Chemical	Gene	production|amod|START_ENTITY Effect|nmod|production Effect|nmod|synthesis synthesis|compound|END_ENTITY	Effect of progesterone_receptor status on maspin synthesis via nitric_oxide production in neutrophils in human breast_cancer .
12677560	0	nitric_oxide	8,20	matrix_metalloproteinase-2	45,71	nitric oxide	matrix metalloproteinase-2	MESH:D009569	100009000(Tax:9986)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|nmod|activation activation|amod|END_ENTITY	Inhaled nitric_oxide inhibits the release of matrix_metalloproteinase-2 , but not platelet activation , during extracorporeal membrane oxygenation in adult rabbits .
19671357	0	nitric_oxide	109,121	matrix_metalloproteinase-2	31,57	nitric oxide	matrix metalloproteinase-2	MESH:D009569	4313	Chemical	Gene	-RSB-|amod|START_ENTITY fibroblasts|nmod|-RSB- upregulates|nmod|fibroblasts upregulates|dobj|expression expression|amod|END_ENTITY	-LSB- Interleukin-1beta upregulates matrix_metalloproteinase-2 expression and activity in cardiac fibroblasts via nitric_oxide synthase pathway -RSB- .
20174726	0	nitric_oxide	81,93	matrix_metalloproteinase-2	104,130	nitric oxide	matrix metalloproteinase-2	MESH:D009569	4313	Chemical	Gene	synthase|amod|START_ENTITY synthase|amod|END_ENTITY	Expression of cyclooxygenase-2 and its relation to histological grade , inducible nitric_oxide synthase , matrix_metalloproteinase-2 , CD-34 , Caspase-3 , and CD8 in invasive_ductal_carcinoma of the breast .
16303975	0	nitric_oxide	54,66	matrix_metalloproteinase-9	14,40	nitric oxide	matrix metalloproteinase-9	MESH:D009569	17395(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY END_ENTITY|nmod|synthase	Activation of matrix_metalloproteinase-9 via neuronal nitric_oxide synthase contributes to NMDA-induced retinal_ganglion_cell_death .
16683234	0	nitric_oxide	29,41	matrix_metalloproteinase-9	72,98	nitric oxide	matrix metalloproteinase-9	MESH:D009569	4318	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	AUF-1 mediates inhibition by nitric_oxide of lipopolysaccharide-induced matrix_metalloproteinase-9 expression in cultured astrocytes .
17452115	0	nitric_oxide	60,72	matrix_metalloproteinase-9	19,45	nitric oxide	matrix metalloproteinase-9	MESH:D009569	81687(Tax:10116)	Chemical	Gene	astrocytes|amod|START_ENTITY Down-regulation|nmod|astrocytes Down-regulation|nmod|expression expression|amod|END_ENTITY	Down-regulation of matrix_metalloproteinase-9 expression by nitric_oxide in lipopolysaccharide-stimulated rat primary astrocytes .
18597705	0	nitric_oxide	68,80	matrix_metalloproteinase-9	27,53	nitric oxide	matrix metalloproteinase-9	MESH:D009569	4318	Chemical	Gene	synthase|amod|START_ENTITY synthase|amod|END_ENTITY	Matrix_metalloproteinase-2 matrix_metalloproteinase-9 and inducible nitric_oxide synthase in oral_leukoplakia : immunohistochemistry and RT-PCR analysis .
24325546	0	nitric_oxide	15,27	matrix_metalloproteinase-9	40,66	nitric oxide	matrix metalloproteinase-9	MESH:D009569	17395(Tax:10090)	Chemical	Gene	Involvement|nmod|START_ENTITY synthase|nsubj|Involvement synthase|advcl|END_ENTITY	Involvement of nitric_oxide synthase in matrix_metalloproteinase-9 - and/or urokinase_plasminogen_activator_receptor-mediated glioma cell migration .
18157556	0	nitric_oxide	14,26	metallothionein-3	49,66	nitric oxide	metallothionein-3	MESH:D009569	4504	Chemical	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	The effect of nitric_oxide on metal release from metallothionein-3 : gradual unfolding of the protein .
25265015	0	nitric_oxide	143,155	methionine_synthase_reductase	103,132	nitric oxide	methionine synthase reductase	MESH:D009569	4552	Chemical	Gene	synthase|compound|START_ENTITY synthase|compound|END_ENTITY	Distinct conformational behaviors of four mammalian dual-flavin reductases -LRB- cytochrome P450 reductase , methionine_synthase_reductase , neuronal nitric_oxide synthase , endothelial nitric_oxide synthase -RRB- determine their unique catalytic profiles .
12399621	0	nitric_oxide	10,22	monocyte_chemoattractant_protein-1	91,125	nitric oxide	monocyte chemoattractant protein-1	MESH:D009569	6347	Chemical	Gene	inhibits|advmod|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Exogenous nitric_oxide inhibits tumor_necrosis_factor-alpha - or interleukin-1-beta-induced monocyte_chemoattractant_protein-1 expression in human mesangial cells .
9299636	0	nitric_oxide	10,22	motilin	53,60	nitric oxide	motilin	MESH:D009569	481748(Tax:9615)	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Effect of nitric_oxide synthase inhibition on plasma motilin release in fasted dogs .
10421431	0	nitric_oxide	20,32	mucin	61,66	nitric oxide	mucin	MESH:D009569	65202(Tax:10116)	Chemical	Gene	generator|amod|START_ENTITY effect|nmod|generator effect|nmod|biosynthesis biosynthesis|compound|END_ENTITY	Stimulant effect of nitric_oxide generator and roxatidine on mucin biosynthesis of rat gastric oxyntic mucosa .
12580882	0	nitric_oxide	10,22	mucin	35,40	nitric oxide	mucin	MESH:D009569	100508689	Chemical	Gene	donation|amod|START_ENTITY Effect|nmod|donation Effect|nmod|production production|compound|END_ENTITY	Effect of nitric_oxide donation on mucin production in vitro .
14990923	0	nitric_oxide	10,22	mucin	26,31	nitric oxide	mucin	MESH:D009569	100508689	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Effect of nitric_oxide on mucin production in experimental otitis media .
8741012	0	nitric_oxide	10,22	mucin	34,39	nitric oxide	mucin	MESH:D009569	100508689	Chemical	Gene	START_ENTITY|dobj|secretion secretion|compound|END_ENTITY	Exogenous nitric_oxide stimulates mucin secretion from LS174T colonic_adenocarcinoma cells .
9163347	0	nitric_oxide	63,75	mucin	15,20	nitric oxide	mucin	MESH:D009569	100508689	Chemical	Gene	cells|nmod|START_ENTITY exocytosis|nmod|cells exocytosis|compound|END_ENTITY	Stimulation of mucin exocytosis from human epithelial cells by nitric_oxide : evidence for a cGMP-dependent and a cGMP-independent pathway .
9585173	0	nitric_oxide	65,77	mucin	34,39	nitric oxide	mucin	MESH:D009569	65202(Tax:10116)	Chemical	Gene	mediated|nmod|START_ENTITY biosynthesis|acl|mediated biosynthesis|compound|END_ENTITY	Lafutidine-induced stimulation of mucin biosynthesis mediated by nitric_oxide is limited to the surface mucous cells of rat gastric oxyntic mucosa .
18070236	0	nitric_oxide	72,84	n-NOS	95,100	nitric oxide	n-NOS	MESH:D009569	4842	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Reduction of interstitial cells of Cajal -LRB- ICC -RRB- associated with neuronal nitric_oxide synthase -LRB- n-NOS -RRB- in patients with achalasia .
15255297	0	nitric_oxide	91,103	nAChR	162,167	nitric oxide	nAChR	MESH:D009569	1137	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Cytochemical correlates of the sleep-wake interface : concerted expression of brain-derived nitric_oxide synthase -LRB- bNOS -RRB- and the nicotinic_acetylcholine_receptor -LRB- nAChR -RRB- in a columnoid organization of the primate prefrontal cortex .
10036989	0	nitric_oxide	72,84	nNOS	95,99	nitric oxide	nNOS	MESH:D009569	18125(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY gene|nmod|synthase gene|dep|END_ENTITY	Circadian locomotor analysis of male mice lacking the gene for neuronal nitric_oxide synthase -LRB- nNOS - / - -RRB- Nitric_oxide -LRB- NO -RRB- is an endogenous gas that functions as a neurotransmitter .
10454144	0	nitric_oxide	33,45	nNOS	56,60	nitric oxide	nNOS	MESH:D009569	24598(Tax:10116)	Chemical	Gene	localization|nmod|START_ENTITY synthase|nmod|localization synthase|dobj|END_ENTITY	In situ localization of neuronal nitric_oxide synthase -LRB- nNOS -RRB- mRNA in the rat retina .
10479675	0	nitric_oxide	30,42	nNOS	53,57	nitric oxide	nNOS	MESH:D009569	4842	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Neuronal expression of neural nitric_oxide synthase -LRB- nNOS -RRB- protein is suppressed by an antisense RNA transcribed from an NOS pseudogene .
10677544	6	nitric_oxide	924,936	nNOS	1150,1154	nitric oxide	nNOS	MESH:D009569	18125(Tax:10090)	Chemical	Gene	synthase|nsubj|START_ENTITY synthase|xcomp|activity activity|nmod|mediates mediates|dep|END_ENTITY	Glutamate neurotransmission involving N-methyl-d-aspartate -LRB- NMDA -RRB- receptors and neuronal nitric_oxide synthase -LRB- nNOS -RRB- activity in part mediates neuronal DNA strand breaks and PARP activity , which are diminished by NMDA antagonists and NOS inhibitors and also diminished in mice with targeted deletion of nNOS gene -LRB- nNOS -LRB- - / - -RRB- -RRB- .
11101149	0	nitric_oxide	66,78	nNOS	89,93	nitric oxide	nNOS	MESH:D009569	100009243(Tax:9986)	Chemical	Gene	gene|amod|START_ENTITY gene|dep|END_ENTITY	5 ' - Flanking sequence and promoter activity of the rabbit neuronal nitric_oxide synthase -LRB- nNOS -RRB- gene .
11146102	0	nitric_oxide	70,82	nNOS	172,176	nitric oxide	nNOS	MESH:D009569	18125(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY isoforms|nmod|synthase isoforms|acl|deficient deficient|advcl|alpha alpha|dep|END_ENTITY	Differential expression of alternatively spliced isoforms of neuronal nitric_oxide synthase -LRB- nNOS -RRB- and N-methyl-D-aspartate_receptors -LRB- NMDAR -RRB- in knockout mice deficient in nNOS alpha -LRB- nNOS alpha -LRB- Delta/Delta -RRB- mice -RRB- .
11146102	0	nitric_oxide	70,82	nNOS	184,188	nitric oxide	nNOS	MESH:D009569	18125(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY isoforms|nmod|synthase isoforms|dep|END_ENTITY	Differential expression of alternatively spliced isoforms of neuronal nitric_oxide synthase -LRB- nNOS -RRB- and N-methyl-D-aspartate_receptors -LRB- NMDAR -RRB- in knockout mice deficient in nNOS alpha -LRB- nNOS alpha -LRB- Delta/Delta -RRB- mice -RRB- .
11146102	0	nitric_oxide	70,82	nNOS	93,97	nitric oxide	nNOS	MESH:D009569	18125(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Differential expression of alternatively spliced isoforms of neuronal nitric_oxide synthase -LRB- nNOS -RRB- and N-methyl-D-aspartate_receptors -LRB- NMDAR -RRB- in knockout mice deficient in nNOS alpha -LRB- nNOS alpha -LRB- Delta/Delta -RRB- mice -RRB- .
11179606	0	nitric_oxide	80,92	nNOS	103,107	nitric oxide	nNOS	MESH:D009569	24598(Tax:10116)	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Orexin-A immunoreactive neurons in the rat hypothalamus do not contain neuronal nitric_oxide synthase -LRB- nNOS -RRB- .
11250781	0	nitric_oxide	25,37	nNOS	48,52	nitric oxide	nNOS	MESH:D009569	24598(Tax:10116)	Chemical	Gene	Regeneration|nmod|START_ENTITY synthase|nsubj|Regeneration synthase|dobj|END_ENTITY	Regeneration of neuronal nitric_oxide synthase -LRB- nNOS -RRB- - containing nerve fibers in rat corpus cavernosum .
11556883	0	nitric_oxide	9,21	nNOS	32,36	nitric oxide	nNOS	MESH:D009569	24598(Tax:10116)	Chemical	Gene	synthase|compound|START_ENTITY mRNA|compound|synthase mRNA|appos|END_ENTITY	Neuronal nitric_oxide synthase -LRB- nNOS -RRB- mRNA is down-regulated , and constitutive_NOS enzymatic activity decreased , in thoracic dorsal root ganglia and spinal cord of the rat by a substance P N-terminal metabolite .
11605676	0	nitric_oxide	15,27	nNOS	38,42	nitric oxide	nNOS	MESH:D009569	4842	Chemical	Gene	synthase|nsubj|START_ENTITY synthase|dobj|inhibitor inhibitor|appos|END_ENTITY	Novel neuronal nitric_oxide synthase -LRB- nNOS -RRB- selective inhibitor , aplysinopsin-type indole_alkaloid , from marine sponge Hyrtios erecta .
11747091	0	nitric_oxide	24,36	nNOS	47,51	nitric oxide	nNOS	MESH:D009569	18125(Tax:10090)	Chemical	Gene	Association|nmod|START_ENTITY synthase|nsubj|Association synthase|dobj|END_ENTITY	Association of neuronal nitric_oxide synthase -LRB- nNOS -RRB- with alpha1-syntrophin at the sarcolemma .
11829530	0	nitric_oxide	172,184	nNOS	195,199	nitric oxide	nNOS	MESH:D009569	24598(Tax:10116)	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Nitric_oxide affects the phosphorylation state of microtubule-associated_protein_2 -LRB- MAP-2 -RRB- and neurofilament : an immunocytochemical study in the brain of rats and neuronal nitric_oxide synthase -LRB- nNOS -RRB- - knockouts .
11935256	0	nitric_oxide	9,21	nNOS	32,36	nitric oxide	nNOS	MESH:D009569	18125(Tax:10090)	Chemical	Gene	synthase|nsubj|START_ENTITY synthase|xcomp|END_ENTITY	Neuronal nitric_oxide synthase -LRB- nNOS -RRB- immunoreactivity in the spinal cord of transgenic_mice with G93A mutant SOD1 gene .
11967278	0	nitric_oxide	41,53	nNOS	64,68	nitric oxide	nNOS	MESH:D009569	24598(Tax:10116)	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Immunocytochemical detection of neuronal nitric_oxide synthase -LRB- nNOS -RRB- - IR in embryonic rat stomach between days 13 and 21 of gestation .
12234657	0	nitric_oxide	23,35	nNOS	46,50	nitric oxide	nNOS	MESH:D009569	18125(Tax:10090)	Chemical	Gene	Deficiency|nmod|START_ENTITY synthase|nsubj|Deficiency synthase|ccomp|worsens worsens|nsubj|END_ENTITY	Deficiency of neuronal nitric_oxide synthase -LRB- nNOS -RRB- worsens alcohol-induced microencephaly and neuronal_loss in developing mice .
12467729	0	nitric_oxide	27,39	nNOS	50,54	nitric oxide	nNOS	MESH:D009569	4842	Chemical	Gene	Relocalization|nmod|START_ENTITY synthase|nsubj|Relocalization synthase|dobj|END_ENTITY	Relocalization of neuronal nitric_oxide synthase -LRB- nNOS -RRB- as a marker for complete restoration of the dystrophin associated protein complex in skeletal muscle .
12850575	0	nitric_oxide	19,31	nNOS	136,140	nitric oxide	nNOS	MESH:D009569	24598(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY triggers|nsubj|activity triggers|nmod|participation participation|nmod|mechanism mechanism|amod|END_ENTITY	Increased neuronal nitric_oxide synthase -LRB- nNOS -RRB- activity triggers picrotoxin-induced seizures in rats and evidence for participation of nNOS mechanism in the action of antiepileptic_drugs .
12850575	0	nitric_oxide	19,31	nNOS	42,46	nitric oxide	nNOS	MESH:D009569	24598(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Increased neuronal nitric_oxide synthase -LRB- nNOS -RRB- activity triggers picrotoxin-induced seizures in rats and evidence for participation of nNOS mechanism in the action of antiepileptic_drugs .
12868590	0	nitric_oxide	49,61	nNOS	81,85	nitric oxide	nNOS	MESH:D009569	18125(Tax:10090)	Chemical	Gene	isoforms|amod|START_ENTITY isoforms|dep|END_ENTITY	Localization of the two constitutively expressed nitric_oxide synthase isoforms -LRB- nNOS and eNOS -RRB- in the same cell types in the saccule maculae of the frog Rana pipiens by immunoelectron microscopy : evidence for a back-up system ?
14759504	0	nitric_oxide	40,52	nNOS	63,67	nitric oxide	nNOS	MESH:D009569	24598(Tax:10116)	Chemical	Gene	alterations|nmod|START_ENTITY synthase|nsubj|alterations synthase|xcomp|expression expression|dep|END_ENTITY	Region-specific alterations of neuronal nitric_oxide synthase -LRB- nNOS -RRB- expression in the amygdala of the aged rats .
15155789	0	nitric_oxide	32,44	nNOS	105,109	nitric oxide	nNOS	MESH:D009569	18125(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY synthase|nmod|exercise exercise|nmod|mice mice|acl|lacking lacking|dobj|END_ENTITY	Impaired regulation of neuronal nitric_oxide synthase and heart rate during exercise in mice lacking one nNOS allele .
15288392	0	nitric_oxide	93,105	nNOS	118,122	nitric oxide	nNOS	MESH:D009569	4842	Chemical	Gene	synthase-I|amod|START_ENTITY synthase-I|appos|END_ENTITY	HIV-1 gp120 stimulates proinflammatory cytokine-mediated pain facilitation via activation of nitric_oxide synthase-I -LRB- nNOS -RRB- .
15488030	0	nitric_oxide	20,32	nNOS	43,47	nitric oxide	nNOS	MESH:D009569	4842	Chemical	Gene	Absence|nmod|START_ENTITY synthase|nsubj|Absence synthase|dobj|END_ENTITY	Absence of neuronal nitric_oxide synthase -LRB- nNOS -RRB- as a pathological marker for the diagnosis of Becker_muscular_dystrophy with rod domain deletions .
15534476	0	nitric_oxide	9,21	nNOS	32,36	nitric oxide	nNOS	MESH:D009569	18125(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY altered|nsubjpass|synthase altered|dep|END_ENTITY	Neuronal nitric_oxide synthase -LRB- nNOS -RRB- positive retinal amacrine cells are altered in the DBA/2NNia mouse , a murine model for angle-closure_glaucoma .
16052497	0	nitric_oxide	55,67	nNOS	78,82	nitric oxide	nNOS	MESH:D009569	24598(Tax:10116)	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Water_deprivation increases the expression of neuronal nitric_oxide synthase -LRB- nNOS -RRB- but not orexin-A in the lateral hypothalamic area of the rat .
16191396	0	nitric_oxide	47,59	nNOS	70,74	nitric oxide	nNOS	MESH:D009569	4842	Chemical	Gene	synthase|amod|START_ENTITY gene|amod|synthase gene|appos|END_ENTITY	A population genomics overview of the neuronal nitric_oxide synthase -LRB- nNOS -RRB- gene and its relationship to migraine susceptibility .
16403412	0	nitric_oxide	39,51	nNOS	62,66	nitric oxide	nNOS	MESH:D009569	24598(Tax:10116)	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Alcohol-induced impairment of neuronal nitric_oxide synthase -LRB- nNOS -RRB- - dependent dilation of cerebral arterioles : role of NAD -LRB- P -RRB- H oxidase .
16431879	0	nitric_oxide	23,35	nNOS	95,99	nitric oxide	nNOS	MESH:D009569	18125(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY Inhibition|nmod|synthase reduces|nsubj|Inhibition reduces|nmod|mice mice|amod|END_ENTITY	Inhibition of neuronal nitric_oxide synthase reduces isoflurane_MAC and motor activity even in nNOS knockout mice .
16490017	6	nitric_oxide	1220,1232	nNOS	1243,1247	nitric oxide	nNOS	MESH:D009569	24598(Tax:10116)	Chemical	Gene	synthase|compound|START_ENTITY contents|compound|synthase contents|appos|END_ENTITY	Neuronal nitric_oxide synthase -LRB- nNOS -RRB- contents were measured in all penises , and AGE levels were determined both in penile tissues and in serum samples .
16698049	0	nitric_oxide	103,115	nNOS	126,130	nitric oxide	nNOS	MESH:D009569	18125(Tax:10090)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Adolescent and adult responsiveness to the incentive value of cocaine reward in mice : role of neuronal nitric_oxide synthase -LRB- nNOS -RRB- gene .
16713369	0	nitric_oxide	33,45	nNOS	70,74	nitric oxide	nNOS	MESH:D009569	18125(Tax:10090)	Chemical	Gene	responses|nmod|START_ENTITY synthase|nsubj|responses synthase|dobj|mice mice|appos|END_ENTITY	Baroreflex responses in neuronal nitric_oxide synthase knoukout mice -LRB- nNOS -RRB- .
16764826	0	nitric_oxide	9,21	nNOS	32,36	nitric oxide	nNOS	MESH:D009569	4842	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Neuronal nitric_oxide synthase -LRB- nNOS -RRB- modulates the JNK1 activity through redox mechanism : a cGMP independent pathway .
16977619	0	nitric_oxide	126,138	nNOS	149,153	nitric oxide	nNOS	MESH:D009569	18125(Tax:10090)	Chemical	Gene	mice|nmod|START_ENTITY hippocampus|nmod|mice neuronal_deficits|nmod|hippocampus synthase|nsubj|neuronal_deficits synthase|dobj|END_ENTITY	Severe alcohol-induced neuronal_deficits in the hippocampus and neocortex of neonatal mice genetically deficient for neuronal nitric_oxide synthase -LRB- nNOS -RRB- .
17184520	0	nitric_oxide	41,53	nNOS	64,68	nitric oxide	nNOS	MESH:D009569	18125(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Regional age-related changes in neuronal nitric_oxide synthase -LRB- nNOS -RRB- , messenger RNA levels and activity in SAMP8 brain .
17306238	0	nitric_oxide	139,151	nNOS	162,166	nitric oxide	nNOS	MESH:D009569	18125(Tax:10090)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Stimulation of the cAMP pathway protects cultured cerebellar granule neurons against alcohol-induced cell death by activating the neuronal nitric_oxide synthase -LRB- nNOS -RRB- gene .
17382301	0	nitric_oxide	9,21	nNOS	32,36	nitric oxide	nNOS	MESH:D009569	24598(Tax:10116)	Chemical	Gene	START_ENTITY|ccomp|modulates modulates|nsubj|blockade blockade|appos|END_ENTITY	Neuronal nitric_oxide synthase -LRB- nNOS -RRB- blockade within the ventrolateral medulla differentially modulates cardiovascular responses and nNOS expression during static skeletal muscle contraction .
18058751	0	nitric_oxide	25,37	nNOS	48,52	nitric oxide	nNOS	MESH:D009569	100009243(Tax:9986)	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Distribution of neuronal nitric_oxide synthase -LRB- nNOS -RRB- - immunoreactive elements in the rabbit piriform cortex .
18058820	0	nitric_oxide	25,37	nNOS	48,52	nitric oxide	nNOS	MESH:D009569	4842	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Variants in the neuronal nitric_oxide synthase -LRB- nNOS , NOS1 -RRB- gene are associated with restless_legs_syndrome .
18306337	0	nitric_oxide	9,21	nNOS	149,153	nitric oxide	nNOS	MESH:D009569	443533(Tax:9940)	Chemical	Gene	synthase|compound|START_ENTITY contribute|nsubj|synthase contribute|nmod|lambs lambs|nmod|congenital_diaphragmatic_hernia congenital_diaphragmatic_hernia|dep|END_ENTITY	Neuronal nitric_oxide synthase does not contribute to the modulation of pulmonary_vascular_tone in fetal lambs with congenital_diaphragmatic_hernia -LRB- nNOS in CDH lambs -RRB- .
18325637	0	nitric_oxide	50,62	nNOS	73,77	nitric oxide	nNOS	MESH:D009569	4842	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|dep|END_ENTITY	Pyrazoles and pyrazolines as neural and inducible nitric_oxide synthase -LRB- nNOS and iNOS -RRB- potential inhibitors -LRB- III -RRB- .
18824032	0	nitric_oxide	34,46	nNOS	57,61	nitric oxide	nNOS	MESH:D009569	18125(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	The protective effect of neuronal nitric_oxide synthase -LRB- nNOS -RRB- against alcohol_toxicity depends upon the NO-cGMP-PKG pathway and NF-kappaB .
19117642	0	nitric_oxide	50,62	nNOS	73,77	nitric oxide	nNOS	MESH:D009569	4842	Chemical	Gene	synthase|amod|START_ENTITY synthase|dep|END_ENTITY	Phenylpyrrole derivatives as neural and inducible nitric_oxide synthase -LRB- nNOS and iNOS -RRB- inhibitors .
19191108	0	nitric_oxide	37,49	nNOS	136,140	nitric oxide	nNOS	MESH:D009569	4842	Chemical	Gene	synthase|compound|START_ENTITY purified|dobj|synthase binds|xcomp|purified binds|parataxis|induced induced|nmod|presence presence|nmod|END_ENTITY	Serotonin binds to purified neuronal nitric_oxide synthase : a possible explanation for ROS production induced by 5HT in the presence of nNOS .
19340543	0	nitric_oxide	28,40	nNOS	51,55	nitric oxide	nNOS	MESH:D009569	18125(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Low -LSB- NaCl -RSB- - induced neuronal nitric_oxide synthase -LRB- nNOS -RRB- expression and NO generation are regulated by intracellular pH in a mouse macula_densa cell line -LRB- NE-MD -RRB- .
19365734	0	nitric_oxide	26,38	nNOS	51,55	nitric oxide	nNOS	MESH:D009569	18125(Tax:10090)	Chemical	Gene	regulation|nmod|START_ENTITY synthase|nsubj|regulation synthase|dobj|I I|appos|END_ENTITY	Cannabinoid regulation of nitric_oxide synthase I -LRB- nNOS -RRB- in neuronal cells .
19429176	0	nitric_oxide	13,25	nNOS	36,40	nitric oxide	nNOS	MESH:D009569	18125(Tax:10090)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The neuronal nitric_oxide synthase -LRB- nNOS -RRB- gene contributes to the regulation of tyrosine_hydroxylase -LRB- TH -RRB- by cocaine .
19478875	0	nitric_oxide	93,105	nNOS	116,120	nitric oxide	nNOS	MESH:D009569	18125(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY role|nmod|synthase target|dep|role target|dep|END_ENTITY	The heart is an early target of anthrax lethal toxin in mice : a protective role for neuronal nitric_oxide synthase -LRB- nNOS -RRB- .
19540363	0	nitric_oxide	30,42	nNOS	53,57	nitric oxide	nNOS	MESH:D009569	4842	Chemical	Gene	variation|nmod|START_ENTITY synthase|nsubj|variation synthase|xcomp|gene gene|dep|END_ENTITY	Genetic variation in neuronal nitric_oxide synthase -LRB- nNOS -RRB- gene and susceptibility to cerebral_malaria in Indian adults .
19560516	0	nitric_oxide	136,148	nNOS	60,64	nitric oxide	nNOS	MESH:D009569	4842	Chemical	Gene	role|nmod|START_ENTITY phosphorylation|dep|role phosphorylation|nmod|synthase synthase|appos|END_ENTITY	Tyrosine phosphorylation of neuronal nitric_oxide synthase -LRB- nNOS -RRB- during hypoxia in the cerebral cortex of newborn piglets : the role of nitric_oxide .
19560516	0	nitric_oxide	37,49	nNOS	60,64	nitric oxide	nNOS	MESH:D009569	4842	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Tyrosine phosphorylation of neuronal nitric_oxide synthase -LRB- nNOS -RRB- during hypoxia in the cerebral cortex of newborn piglets : the role of nitric_oxide .
21505843	0	nitric_oxide	86,98	nNOS	109,113	nitric oxide	nNOS	MESH:D009569	4842	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Exercise-induced angiogenesis correlates with the up-regulated expression of neuronal nitric_oxide synthase -LRB- nNOS -RRB- in human skeletal muscle .
21506911	0	nitric_oxide	119,131	nNOS	50,54	nitric oxide	nNOS	MESH:D009569	4842	Chemical	Gene	role|nmod|START_ENTITY Identification|dep|role Identification|nmod|synthase synthase|appos|END_ENTITY	Identification of neuronal nitric_oxide synthase -LRB- nNOS -RRB- in human penis : a potential role of reduced neuronally-derived nitric_oxide in erectile_dysfunction .
21506911	0	nitric_oxide	27,39	nNOS	50,54	nitric oxide	nNOS	MESH:D009569	4842	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Identification of neuronal nitric_oxide synthase -LRB- nNOS -RRB- in human penis : a potential role of reduced neuronally-derived nitric_oxide in erectile_dysfunction .
21699209	0	nitric_oxide	141,153	nNOS	164,168	nitric oxide	nNOS	MESH:D009569	4842	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Design , synthesis , and biological evaluation of 3,4-dihydroquinolin-2 -LRB- 1H -RRB- - one and 1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric_oxide synthase -LRB- nNOS -RRB- inhibitors .
21840380	0	nitric_oxide	74,86	nNOS	97,101	nitric oxide	nNOS	MESH:D009569	24598(Tax:10116)	Chemical	Gene	synthase|nsubj|START_ENTITY synthase|xcomp|expression expression|dep|END_ENTITY	Anteroventral third ventricle -LRB- AV3V -RRB- lesion affects hypothalamic neuronal nitric_oxide synthase -LRB- nNOS -RRB- expression following water deprivation .
21923116	0	nitric_oxide	146,158	nNOS	169,173	nitric oxide	nNOS	MESH:D009569	4842	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Discovery of N - -LRB- 3 - -LRB- 1-methyl-1 ,2,3,6 - tetrahydropyridin-4-yl -RRB- -1 H-indol-6-yl -RRB- _ thiophene-2-carboximidamide as a selective inhibitor of human neuronal nitric_oxide synthase -LRB- nNOS -RRB- for the treatment of pain .
21945318	0	nitric_oxide	29,41	nNOS	52,56	nitric oxide	nNOS	MESH:D009569	4842	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	The beta-isoform of neuronal nitric_oxide synthase -LRB- nNOS -RRB- lacking the PDZ domain is localized at the sarcolemma .
21995890	0	nitric_oxide	24,36	nNOS	47,51	nitric oxide	nNOS	MESH:D009569	443533(Tax:9940)	Chemical	Gene	Involvement|nmod|START_ENTITY synthase|nsubj|Involvement synthase|dobj|END_ENTITY	Involvement of neuronal nitric_oxide synthase -LRB- nNOS -RRB- in the regulation of migrating motor complex -LRB- MMC -RRB- in sheep .
22003386	0	nitric_oxide	9,21	nNOS	99,103	nitric oxide	nNOS	MESH:D009569	18125(Tax:10090)	Chemical	Gene	synthase-rescue|compound|START_ENTITY require|nsubj|synthase-rescue require|dobj|localization localization|amod|END_ENTITY	Neuronal nitric_oxide synthase-rescue of dystrophin/utrophin double knockout mice does not require nNOS localization to the cell membrane .
22175766	0	nitric_oxide	181,193	nNOS	204,208	nitric oxide	nNOS	MESH:D009569	4842	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Discovery of cis-N - -LRB- 1 - -LRB- 4 - -LRB- methylamino -RRB- cyclohexyl -RRB- indolin-6-yl -RRB- thiophene-2-carboximidamide : a 1,6-disubstituted _ indoline derivative as a highly selective inhibitor of human neuronal nitric_oxide synthase -LRB- nNOS -RRB- without any cardiovascular liabilities .
22258124	0	nitric_oxide	9,21	nNOS	32,36	nitric oxide	nNOS	MESH:D009569	100520934	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Neuronal nitric_oxide synthase , nNOS , regulates renal hemodynamics in the postnatal developing piglet .
22318159	0	nitric_oxide	65,77	nNOS	88,92	nitric oxide	nNOS	MESH:D009569	4842	Chemical	Gene	START_ENTITY|dobj|inhibitors inhibitors|appos|END_ENTITY	3,5-Disubstituted _ indole derivatives as selective human neuronal nitric_oxide synthase -LRB- nNOS -RRB- inhibitors .
22335555	0	nitric_oxide	59,71	nNOS	82,86	nitric oxide	nNOS	MESH:D009569	4842	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric_oxide synthase -LRB- nNOS -RRB- inhibitors : lead optimization studies resulting in the identification of N - -LRB- 1 - -LRB- 2 - -LRB- methylamino -RRB- ethyl -RRB- -1,2,3,4 - tetrahydroquinolin-6-yl -RRB- thiophene-2-carboximidamide as a preclinical development candidate .
22370270	0	nitric_oxide	117,129	nNOS	140,144	nitric oxide	nNOS	MESH:D009569	4842	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Novel , druglike 1,7-disubstituted _ 2,3,4,5-tetrahydro-1H-benzo -LSB- b -RSB- azepine-based selective inhibitors of human neuronal nitric_oxide synthase -LRB- nNOS -RRB- .
22840695	0	nitric_oxide	79,91	nNOS	102,106	nitric oxide	nNOS	MESH:D009569	4842	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Discovery of a potent , orally bioavailable and highly selective human neuronal nitric_oxide synthase -LRB- nNOS -RRB- inhibitor , N - -LRB- 1 - -LRB- piperidin-4-yl -RRB- indolin-5-yl -RRB- thiophene-2-carboximidamide as a pre-clinical development candidate for the treatment of migraine .
22921991	0	nitric_oxide	29,41	nNOS	52,56	nitric oxide	nNOS	MESH:D009569	24598(Tax:10116)	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Is there a role for neuronal nitric_oxide synthase -LRB- nNOS -RRB- in cytokine toxicity to pancreatic beta cells ?
23199242	0	nitric_oxide	10,22	nNOS	38,42	nitric oxide	nNOS	MESH:D009569	4842	Chemical	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Targeting nitric_oxide signaling with nNOS inhibitors as a novel strategy for the therapy and prevention of human melanoma .
23278407	1	nitric_oxide	200,212	nNOS	223,227	nitric oxide	nNOS	MESH:D009569	24598(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	The aims of the present study were to determine the mechanism underlying enhanced neuronal nitric_oxide synthase -LRB- nNOS -RRB- activity in the brain of hypertensive Dahl_salt-sensitive -LRB- DSS -RRB- rats and the consequences of enhanced nNOS activity .
23811396	2	nitric_oxide	327,339	nNOS	350,354	nitric oxide	nNOS	MESH:D009569	4842	Chemical	Gene	synthase|amod|START_ENTITY expression|amod|synthase expression|appos|END_ENTITY	We have previously demonstrated the neuronal nitric_oxide synthase -LRB- nNOS -RRB- expression and nitric_oxide -LRB- NO -RRB- production may be regulated by NF-kB acetylation via an NF-kB responsive element within the nNOS promoter in neuronal cells .
24720557	0	nitric_oxide	38,50	nNOS	61,65	nitric oxide	nNOS	MESH:D009569	18125(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY synthase|dep|END_ENTITY	Murine genetic deficiency of neuronal nitric_oxide synthase -LRB- nNOS -LRB- - / - -RRB- -RRB- and interstitial cells of Cajal -LRB- W/W -LRB- v -RRB- -RRB- : Implications for achalasia ?
24830557	0	nitric_oxide	54,66	nNOS	77,81	nitric oxide	nNOS	MESH:D009569	4842	Chemical	Gene	Inhibitors|amod|START_ENTITY Inhibitors|appos|END_ENTITY	The discovery of potentially selective human neuronal nitric_oxide synthase -LRB- nNOS -RRB- Inhibitors : a combination of pharmacophore modelling , CoMFA , virtual screening and molecular docking studies .
24930124	0	nitric_oxide	23,35	nNOS	46,50	nitric oxide	nNOS	MESH:D009569	24598(Tax:10116)	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Activation of neuronal nitric_oxide synthase -LRB- nNOS -RRB- signaling pathway in 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- - induced neurotoxicity .
25392169	0	nitric_oxide	21,33	nNOS	44,48	nitric oxide	nNOS	MESH:D009569	100729682	Chemical	Gene	role|nmod|START_ENTITY synthase|nsubj|role synthase|dobj|END_ENTITY	The role of neuronal nitric_oxide synthase -LRB- nNOS -RRB- in the estrogenic attenuation of cannabinoid-induced changes in energy homeostasis .
25796222	0	nitric_oxide	118,130	nNOS	141,145	nitric oxide	nNOS	MESH:D009569	18125(Tax:10090)	Chemical	Gene	protects|nmod|START_ENTITY protects|dep|activity activity|appos|END_ENTITY	Near infrared radiation protects against oxygen-glucose_deprivation-induced neurotoxicity by down-regulating neuronal nitric_oxide synthase -LRB- nNOS -RRB- activity in vitro .
7556767	0	nitric_oxide	140,152	nNOS	163,167	nitric oxide	nNOS	MESH:D009569	24598(Tax:10116)	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	A modified method allows for correlation between NADPH-diaphorase histochemistry and immunohistochemistry for the demonstration of neuronal nitric_oxide synthase -LRB- nNOS -RRB- .
8782909	0	nitric_oxide	49,61	nNOS	72,76	nitric oxide	nNOS	MESH:D009569	24598(Tax:10116)	Chemical	Gene	mRNA|amod|START_ENTITY mRNA|dep|END_ENTITY	Immobilization-induced stress activates neuronal nitric_oxide synthase -LRB- nNOS -RRB- mRNA and protein in hypothalamic-pituitary-adrenal_axis in rats .
8817727	0	nitric_oxide	29,41	nNOS	52,56	nitric oxide	nNOS	MESH:D009569	24598(Tax:10116)	Chemical	Gene	increases|nmod|START_ENTITY synthase|nsubj|increases synthase|xcomp|mRNA mRNA|dep|END_ENTITY	Marked increases in neuronal nitric_oxide synthase -LRB- nNOS -RRB- mRNA and NADPH-diaphorase histostaining in adrenal cortex after immobilization stress in rats .
8883932	0	nitric_oxide	9,21	nNOS	32,36	nitric oxide	nNOS	MESH:D009569	4842	Chemical	Gene	synthase|nsubj|START_ENTITY synthase|xcomp|expression expression|dep|END_ENTITY	Neuronal nitric_oxide synthase -LRB- nNOS -RRB- mRNA expression and NADPH-diaphorase staining in the frontal cortex , visual cortex and hippocampus of control and Alzheimer 's _ disease brains .
9255165	0	nitric_oxide	76,88	nNOS	99,103	nitric oxide	nNOS	MESH:D009569	24598(Tax:10116)	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Synthesis , in vivo evaluation and PET study of a carbon-11-labeled neuronal nitric_oxide synthase -LRB- nNOS -RRB- inhibitor S-methyl-L-thiocitrulline .
9278526	1	nitric_oxide	145,157	nNOS	168,172	nitric oxide	nNOS	MESH:D009569	18125(Tax:10090)	Chemical	Gene	mice|amod|START_ENTITY mice|amod|synthase synthase|dep|END_ENTITY	We investigated the role of neuronal -LRB- type I -RRB- nitric_oxide synthase -LRB- nNOS -RRB- in NMDA-mediated excitotoxicity in wild-type -LRB- SV129 and C57BL/6J -RRB- and type I NOS knock-out -LRB- nNOS - / - -RRB- mice and examined its relationship to apoptosis .
9729355	0	nitric_oxide	39,51	nNOS	62,66	nitric oxide	nNOS	MESH:D009569	24598(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY inhibitor|amod|synthase inhibitor|appos|END_ENTITY	Effects of 7-nitroindazole , a neuronal nitric_oxide synthase -LRB- nNOS -RRB- inhibitor , on locomotor activity and contextual fear conditioning in rats .
9748571	0	nitric_oxide	42,54	nNOS	65,69	nitric oxide	nNOS	MESH:D009569	4842	Chemical	Gene	characteristics|nmod|START_ENTITY synthase|nsubj|characteristics synthase|xcomp|neurons neurons|dep|END_ENTITY	Developmental characteristics of neuronal nitric_oxide synthase -LRB- nNOS -RRB- immunoreactive neurons in fetal to adolescent human brains .
10813276	0	nitric_oxide	59,71	nerve_growth_factor	73,92	nitric oxide	nerve growth factor	MESH:D009569	4803	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	A histochemical study of the rheumatoid_synovium : focus on nitric_oxide , nerve_growth_factor high affinity receptor , and innervation .
12034080	0	nitric_oxide	43,55	nerve_growth_factor	11,30	nitric oxide	nerve growth factor	MESH:D009569	310738(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of nerve_growth_factor on neuronal nitric_oxide production after spinal_cord_injury in rats .
11000493	0	nitric_oxide	90,102	neural_cell_adhesion_molecules	29,59	nitric oxide	neural cell adhesion molecules	MESH:D009569	4684	Chemical	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	Immune modulatory effects of neural_cell_adhesion_molecules on lipopolysaccharide-induced nitric_oxide production by cultured glia .
12552637	0	nitric_oxide	31,43	neurokinin-1_receptor	55,76	nitric oxide	neurokinin-1 receptor	MESH:D009569	24807(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY synthase|dep|END_ENTITY	Morphology and distribution of nitric_oxide synthase - , neurokinin-1_receptor - , calretinin - , calbindin - , and neurofilament-M-immunoreactive neurons in the myenteric and submucosal plexuses of the rat small intestine .
8495370	0	nitric_oxide	69,81	neuropeptide_Y	42,56	nitric oxide	neuropeptide Y	MESH:D009569	101096968	Chemical	Gene	mediated|nmod|START_ENTITY mediated|nsubj|effect effect|nmod|END_ENTITY	Transient cerebral vasodilatory effect of neuropeptide_Y mediated by nitric_oxide .
9105707	0	nitric_oxide	23,35	neurotensin	50,61	nitric oxide	neurotensin	MESH:D009569	299757(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Negative modulation of nitric_oxide production by neurotensin as a putative mechanism of the diuretic action of SR_48692 in rats .
9277430	0	nitric_oxide	87,99	neurotensin	37,48	nitric oxide	neurotensin	MESH:D009569	299757(Tax:10116)	Chemical	Gene	involvement|nmod|START_ENTITY Inhibition|dep|involvement Inhibition|nmod|activity activity|nmod|END_ENTITY	Inhibition of mechanical activity by neurotensin in rat proximal colon : involvement of nitric_oxide .
9812881	0	nitric_oxide	16,28	neurotensin	66,77	nitric oxide	neurotensin	MESH:D009569	67405(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|effect effect|nmod|END_ENTITY	-LSB- Involvement of nitric_oxide and cGMP in the protective effect of neurotensin on hepatocytes -RSB- .
25551967	0	nitric_oxide	60,72	neutrophil_gelatinase_associated_lipocalin	6,48	nitric oxide	neutrophil gelatinase associated lipocalin	MESH:D009569	3934	Chemical	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Serum neutrophil_gelatinase_associated_lipocalin and plasma nitric_oxide levels in healthy and preeclamptic pregnants .
12679149	0	nitric_oxide	82,94	nitric_oxide_synthase-2	57,80	nitric oxide	nitric oxide synthase-2	MESH:D009569	18126(Tax:10090)	Chemical	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Responsiveness to noradrenaline in aorta from wild-type , nitric_oxide_synthase-2 , nitric_oxide synthase-3 and alpha2A/D-adrenoceptor knockout mice .
12097367	0	nitric_oxide	112,124	nonstructural_protein_1	70,93	nitric oxide	nonstructural protein 1	MESH:D009569	10625	Chemical	Gene	production|nmod|START_ENTITY END_ENTITY|nmod|production	Endothelial cell apoptosis induced by antibodies against dengue virus nonstructural_protein_1 via production of nitric_oxide .
24141017	0	nitric_oxide	191,203	nuclear_factor-kB	154,171	nitric oxide	nuclear factor-kB	MESH:D009569	81736(Tax:10116)	Chemical	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Heat_shock_protein_70 protects against seizure-induced neuronal cell death in the hippocampus following experimental status_epilepticus via inhibition of nuclear_factor-kB activation-induced nitric_oxide synthase II expression .
9122255	0	nitric_oxide	107,119	nuclear_factor_kappaB	50,71	nitric oxide	nuclear factor kappaB	MESH:D009569	4790	Chemical	Gene	START_ENTITY|nsubj|activity activity|compound|END_ENTITY	Neuronal -LRB- type I -RRB- nitric_oxide synthase regulates nuclear_factor_kappaB activity and immunologic -LRB- type II -RRB- nitric_oxide synthase expression .
19615412	0	nitric_oxide	136,148	nuclear_respiratory_factor_1	81,109	nitric oxide	nuclear respiratory factor 1	MESH:D009569	4899	Chemical	Gene	synthase|compound|START_ENTITY END_ENTITY|nmod|synthase	Transcriptional coupling of synaptic transmission and energy metabolism : role of nuclear_respiratory_factor_1 in co-regulating neuronal nitric_oxide synthase and cytochrome c oxidase genes in neurons .
12489640	0	nitric_oxide	66,78	organic_anion_transporter_2	19,46	nitric oxide	organic anion transporter 2	MESH:D009569	170698(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Down-regulation of organic_anion_transporter_2 mRNA expression by nitric_oxide in primary cultured rat hepatocytes .
17234720	0	nitric_oxide	213,225	ornithine_decarboxylase	157,180	nitric oxide	ornithine decarboxylase	MESH:D009569	18263(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY synthase|amod|END_ENTITY	Xanthorrhizol inhibits 12-O-tetradecanoylphorbol-13-acetate-induced acute inflammation and two-stage mouse skin_carcinogenesis by blocking the expression of ornithine_decarboxylase , cyclooxygenase-2 and inducible nitric_oxide synthase through mitogen-activated protein kinases and/or the nuclear factor-kappa B. Xanthorrhizol is an active component isolated from Curcuma xanthorrhiza Roxb .
9719478	0	nitric_oxide	41,53	ornithine_decarboxylase	64,87	nitric oxide	ornithine decarboxylase	MESH:D009569	4953	Chemical	Gene	donors|amod|START_ENTITY donors|nmod|activity activity|amod|END_ENTITY	Differential inhibitory effects of three nitric_oxide donors on ornithine_decarboxylase activity in human colon_carcinoma cells .
9884080	0	nitric_oxide	50,62	ornithine_decarboxylase	14,37	nitric oxide	ornithine decarboxylase	MESH:D009569	18263(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|potentiates potentiates|amod|END_ENTITY	Inhibition of ornithine_decarboxylase potentiates nitric_oxide production in LPS-activated J774 cells .
12713454	0	nitric_oxide	22,34	oxytocin	10,18	nitric oxide	oxytocin	MESH:D009569	5020	Chemical	Gene	secretion|amod|START_ENTITY Effect|nmod|secretion Effect|nmod|END_ENTITY	Effect of oxytocin on nitric_oxide activity controlling gonadotropin secretion in humans .
16769231	0	nitric_oxide	7,19	oxytocin	69,77	nitric oxide	oxytocin	MESH:D009569	18429(Tax:10090)	Chemical	Gene	inactivation|compound|START_ENTITY affects|nsubj|inactivation affects|dobj|profile profile|nmod|END_ENTITY	Neural nitric_oxide gene inactivation affects the release profile of oxytocin into the blood in response to forced swimming .
10618436	0	nitric_oxide	16,28	p21	43,46	nitric oxide	p21	MESH:D009569	644914	Chemical	Gene	activation|amod|START_ENTITY Requirement|nmod|activation Requirement|nmod|END_ENTITY	Requirement for nitric_oxide activation of p21 -LRB- ras -RRB- / extracellular regulated kinase in neuronal_ischemic preconditioning .
10820188	0	nitric_oxide	75,87	p21	44,47	nitric oxide	p21	MESH:D009569	24525(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY induction|nmod|synthase inhibits|dobj|induction inhibits|nsubj|Expression Expression|nmod|mutant mutant|nmod|END_ENTITY	Expression of a dominant-negative mutant of p21 -LRB- ras -RRB- inhibits induction of nitric_oxide synthase and activation of nuclear factor-kappaB in primary astrocytes .
10842159	0	nitric_oxide	10,22	p21	62,65	nitric oxide	p21	MESH:D009569	24525(Tax:10116)	Chemical	Gene	upregulates|amod|START_ENTITY upregulates|amod|END_ENTITY	Inducible nitric_oxide synthase -LRB- iNOS -RRB- expression upregulates p21 and inhibits vascular smooth muscle cell proliferation through p42/44 mitogen-activated protein kinase activation and independent of p53 and cyclic_guanosine_monophosphate .
22401965	0	nitric_oxide	59,71	p21	33,36	nitric oxide	p21	MESH:D009569	1026	Chemical	Gene	arrest|compound|START_ENTITY pathway|nmod|arrest Cip1/Waf1|amod|pathway Cip1/Waf1|amod|END_ENTITY	Activation of the BRCA1/Chk1/p53 / p21 -LRB- Cip1/Waf1 -RRB- pathway by nitric_oxide and cell cycle arrest in human neuroblastoma NB69 cells .
10051531	0	nitric_oxide	68,80	p38	0,3	nitric oxide	p38	MESH:D009569	1432	Chemical	Gene	induction|amod|START_ENTITY required|nmod|induction mitogen-activated|ccomp|required mitogen-activated|nsubj|END_ENTITY	p38 but not p44/42 mitogen-activated protein kinase is required for nitric_oxide synthase induction mediated by lipopolysaccharide in RAW 264.7 macrophages .
10648884	0	nitric_oxide	156,168	p38	35,38	nitric oxide	p38	MESH:D009569	81649(Tax:10116)	Chemical	Gene	modulation|nmod|START_ENTITY calcium|dep|modulation contributes|nmod|calcium contributes|nsubj|activation activation|nmod|END_ENTITY	Calmodulin-dependent activation of p38 and p42/44 mitogen-activated protein kinases contributes to c-fos expression by calcium in PC12 cells : modulation by nitric_oxide .
10880762	0	nitric_oxide	49,61	p38	134,137	nitric oxide	p38	MESH:D009569	26416(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY inhibits|dobj|production inhibits|advcl|blocking blocking|dobj|activation activation|amod|END_ENTITY	2-Amino-3-methylimidazo -LSB- 4,5-f -RSB- quinoline inhibits nitric_oxide production in lipopolysaccharide-stimulated RAW 264.7 cells by blocking p38 kinase activation .
11162622	0	nitric_oxide	91,103	p38	15,18	nitric oxide	p38	MESH:D009569	26416(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY Involvement|nmod|production Involvement|nmod|Kinase Kinase|amod|END_ENTITY	Involvement of p38 MAP Kinase in the inhibitory effects of phosphatidylserine liposomes on nitric_oxide production from macrophages stimulated with LPS .
11527399	0	nitric_oxide	78,90	p38	37,40	nitric oxide	p38	MESH:D009569	81649(Tax:10116)	Chemical	Gene	MAPK|nmod|START_ENTITY MAPK|nsubj|Role Role|nmod|END_ENTITY	Role of G proteins and modulation of p38 MAPK activation in the protection by nitric_oxide against ischemia-reoxygenation injury .
11693258	0	nitric_oxide	43,55	p38	113,116	nitric oxide	p38	MESH:D009569	1432	Chemical	Gene	expression|amod|START_ENTITY expression|dep|involvement involvement|nmod|mechanism mechanism|amod|END_ENTITY	Advanced_glycosylation end products induce nitric_oxide synthase expression in C6_glioma cells : involvement of a p38 MAP kinase-dependent mechanism .
11920316	0	nitric_oxide	128,140	p38	24,27	nitric oxide	p38	MESH:D009569	26416(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY inhibitors|nmod|synthase inhibitors|nsubj|effects effects|nmod|kinase kinase|amod|END_ENTITY	Differential effects of p38 - and extracellular signal-regulated kinase mitogen-activated protein kinase inhibitors on inducible nitric_oxide synthase and tumor_necrosis_factor production in murine macrophages stimulated with Streptococcus_pneumoniae .
12023055	0	nitric_oxide	107,119	p38	0,3	nitric oxide	p38	MESH:D009569	26416(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY induced|dobj|expression mediates|acl|induced mediates|amod|END_ENTITY	p38 mitogen-activated protein kinase mediates lipopolysaccharide , not interferon-gamma , - induced inducible nitric_oxide synthase expression in mouse BV2 microglial cells .
12414118	0	nitric_oxide	16,28	p38	63,66	nitric oxide	p38	MESH:D009569	26416(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY induces|dobj|production induces|nmod|microglia microglia|nmod|pathway pathway|amod|END_ENTITY	Hypoxia induces nitric_oxide production in mouse microglia via p38 mitogen-activated protein kinase pathway .
12509937	0	nitric_oxide	55,67	p38	121,124	nitric oxide	p38	MESH:D009569	1432	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|signal signal|amod|END_ENTITY	-LSB- Advanced glycation end products inhibit production of nitric_oxide by human endothelial cells through activation of the p38 signal pathway -RSB- .
14751542	0	nitric_oxide	107,119	p38	33,36	nitric oxide	p38	MESH:D009569	1432	Chemical	Gene	induction|nmod|START_ENTITY implication|nmod|induction activation|dep|implication activation|nmod|MAPK MAPK|amod|END_ENTITY	PKA-dependent activation of PKC , p38 MAPK and IKK in macrophage : implication in the induction of inducible nitric_oxide synthase and interleukin-6 by dibutyryl_cAMP .
14998552	0	nitric_oxide	63,75	p38	14,17	nitric oxide	p38	MESH:D009569	1432	Chemical	Gene	production|compound|START_ENTITY blocks|dobj|production blocks|nsubj|Inhibition Inhibition|nmod|kinases kinases|compound|END_ENTITY	Inhibition of p38 and ERK MAP kinases blocks endotoxin-induced nitric_oxide production and differentially modulates cytokine expression .
15848219	0	nitric_oxide	15,27	p38	8,11	nitric oxide	p38	MESH:D009569	1432	Chemical	Gene	synthase|amod|START_ENTITY END_ENTITY|nmod|synthase	Role of p38 in nitric_oxide synthase and cyclooxygenase expression , and nitric_oxide and PGE2 synthesis in human gingival fibroblasts stimulated with lipopolysaccharides .
16207333	0	nitric_oxide	74,86	p38	104,107	nitric oxide	p38	MESH:D009569	1432	Chemical	Gene	synthase|compound|START_ENTITY expression|nmod|synthase stimulate|dobj|expression stimulate|nmod|END_ENTITY	Octacalcium_phosphate crystals directly stimulate expression of inducible nitric_oxide synthase through p38 and JNK mitogen-activated protein kinases in articular chondrocytes .
16376947	0	nitric_oxide	69,81	p38	121,124	nitric oxide	p38	MESH:D009569	81649(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY expression|nmod|synthase stimulates|dobj|expression stimulates|nmod|activation activation|amod|END_ENTITY	The astroglial-derived S100beta protein stimulates the expression of nitric_oxide synthase in rodent macrophages through p38 MAP kinase activation .
16713109	0	nitric_oxide	26,38	p38	8,11	nitric oxide	p38	MESH:D009569	1432	Chemical	Gene	synthase|amod|START_ENTITY synthase|amod|END_ENTITY	Role of p38 and inducible nitric_oxide synthase in the in vivo dopaminergic cells ' degeneration induced by inflammatory processes after lipopolysaccharide injection .
17101217	0	nitric_oxide	23,35	p38	120,123	nitric oxide	p38	MESH:D009569	1432	Chemical	Gene	antagonizes|compound|START_ENTITY Inhibition|nmod|antagonizes morphine|nsubj|Inhibition morphine|nmod|activation activation|nmod|MAPK MAPK|amod|END_ENTITY	Inhibition of neuronal nitric_oxide synthase antagonizes morphine antinociceptive tolerance by decreasing activation of p38 MAPK in the spinal microglia .
17570679	0	nitric_oxide	92,104	p38	41,44	nitric oxide	p38	MESH:D009569	26416(Tax:10090)	Chemical	Gene	overproduction|nmod|START_ENTITY activation|nmod|overproduction MAP|dobj|activation MAP|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of lysosomal storage-induced p38 MAP kinase activation in the overproduction of nitric_oxide by microglia in cathepsin_D-deficient mice .
18205920	0	nitric_oxide	54,66	p38	115,118	nitric oxide	p38	MESH:D009569	1432	Chemical	Gene	synthase|compound|START_ENTITY inhibition|nmod|synthase associated|nsubjpass|inhibition associated|nmod|activity activity|nmod|kinase kinase|amod|END_ENTITY	Pioglitazone inhibition of lipopolysaccharide-induced nitric_oxide synthase is associated with altered activity of p38 MAP kinase and PI3K/Akt .
18344257	0	nitric_oxide	14,26	p38	128,131	nitric oxide	p38	MESH:D009569	417553(Tax:9031)	Chemical	Gene	action|nmod|START_ENTITY mediated|nsubjpass|action mediated|advcl|alter alter|nsubj|pathways pathways|amod|END_ENTITY	The action of nitric_oxide to enhance cell survival in chick cardiomyocytes is mediated through a cGMP and ERK1/2 pathway while p38 mitogen-activated protein kinase-dependent pathways do not alter cell death .
18929556	0	nitric_oxide	33,45	p38	108,111	nitric oxide	p38	MESH:D009569	26416(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY synthase|nmod|kinase kinase|amod|END_ENTITY	Ikarisoside_A inhibits inducible nitric_oxide synthase in lipopolysaccharide-stimulated RAW 264.7 cells via p38 kinase and nuclear factor-kappaB signaling pathways .
20026303	0	nitric_oxide	32,44	p38	84,87	nitric oxide	p38	MESH:D009569	26416(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY suppresses|dobj|expression suppresses|nmod|inactivation inactivation|nmod|END_ENTITY	Carabrol suppresses LPS-induced nitric_oxide synthase expression by inactivation of p38 and JNK via inhibition of I-kappaBalpha degradation in RAW 264.7 cells .
22083995	0	nitric_oxide	53,65	p38	163,166	nitric oxide	p38	MESH:D009569	26416(Tax:10090)	Chemical	Gene	factor-a|compound|START_ENTITY suppresses|dobj|factor-a suppresses|nmod|inhibition inhibition|nmod|END_ENTITY	The chloroform fraction of Solanum nigrum suppresses nitric_oxide and tumor necrosis factor-a in LPS-stimulated mouse peritoneal macrophages through inhibition of p38 , JNK and ERK1/2 .
22639878	0	nitric_oxide	10,22	p38	64,67	nitric oxide	p38	MESH:D009569	81649(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|amod|END_ENTITY	Exogenous nitric_oxide negatively regulates the S-nitrosylation p38 mitogen-activated protein kinase activation during cerebral_ischaemia and reperfusion .
24016057	0	nitric_oxide	52,64	p38	99,102	nitric oxide	p38	MESH:D009569	26416(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY production|nmod|inhibition inhibition|amod|END_ENTITY	Vermelhotin , an anti-inflammatory agent , suppresses nitric_oxide production in RAW 264.7 cells via p38 inhibition .
24060108	0	nitric_oxide	21,33	p38	101,104	nitric oxide	p38	MESH:D009569	1432	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|amod|END_ENTITY	Melatonin suppresses nitric_oxide production in glial cultures by pro-inflammatory cytokines through p38 MAPK inhibition .
9614146	0	nitric_oxide	47,59	p38	88,91	nitric oxide	p38	MESH:D009569	81649(Tax:10116)	Chemical	Gene	synthesis|compound|START_ENTITY requires|nsubj|synthesis requires|dobj|END_ENTITY	Interleukin-1beta-induced rat pancreatic islet nitric_oxide synthesis requires both the p38 and extracellular_signal-regulated_kinase_1 / 2 mitogen-activated protein kinases .
12390692	0	nitric_oxide	99,111	p38_mitogen-activated_protein_kinase	8,44	nitric oxide	p38 mitogen-activated protein kinase	MESH:D009569	1432	Chemical	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Role of p38_mitogen-activated_protein_kinase in lipopolysaccharide-induced expression of inducible nitric_oxide synthase in human endothelial cells .
10222219	0	nitric_oxide	21,33	p53	61,64	nitric oxide	p53	MESH:D009569	7157	Chemical	Gene	induced|nmod|START_ENTITY Apoptosis|acl|induced associated|nsubjpass|Apoptosis associated|nmod|expression expression|compound|END_ENTITY	Apoptosis induced by nitric_oxide is associated with nuclear p53 protein expression in cultured osteoarthritic synoviocytes .
10597241	0	nitric_oxide	123,135	p53	0,3	nitric oxide	p53	MESH:D009569	7157	Chemical	Gene	precedes|advcl|START_ENTITY process|acl:relcl|precedes demanding|dobj|process energy|acl|demanding energy|nsubj|accumulation accumulation|compound|END_ENTITY	p53 accumulation in apoptotic macrophages is an energy demanding process that precedes cytochrome_c release in response to nitric_oxide .
10842159	0	nitric_oxide	10,22	p53	199,202	nitric oxide	p53	MESH:D009569	301300(Tax:10116)	Chemical	Gene	upregulates|amod|START_ENTITY vascular|nsubj|upregulates vascular|nmod|kinase kinase|nmod|END_ENTITY	Inducible nitric_oxide synthase -LRB- iNOS -RRB- expression upregulates p21 and inhibits vascular smooth muscle cell proliferation through p42/44 mitogen-activated protein kinase activation and independent of p53 and cyclic_guanosine_monophosphate .
11483405	0	nitric_oxide	55,67	p53	22,25	nitric oxide	p53	MESH:D009569	7157	Chemical	Gene	targets|nmod|START_ENTITY END_ENTITY|nmod|targets	Transcription factors p53 and HIF-1alpha as targets of nitric_oxide .
15126337	0	nitric_oxide	40,52	p53	114,117	nitric oxide	p53	MESH:D009569	7157	Chemical	Gene	induced|nmod|START_ENTITY induced|xcomp|expressing expressing|dobj|END_ENTITY	Apoptotic signaling pathways induced by nitric_oxide in human lymphoblastoid cells expressing wild-type or mutant p53 .
15609395	0	nitric_oxide	14,26	p53	83,86	nitric oxide	p53	MESH:D009569	7157	Chemical	Gene	Expression|nmod|START_ENTITY synthase|nsubj|Expression synthase|nmod|END_ENTITY	Expression of nitric_oxide synthase in human gastric_carcinoma and its relation to p53 , PCNA .
18506185	0	nitric_oxide	17,29	p53	92,95	nitric oxide	p53	MESH:D009569	7157	Chemical	Gene	levels|amod|START_ENTITY alters|dobj|levels alters|parataxis|involvement involvement|nmod|regulation regulation|compound|END_ENTITY	Cisplatin alters nitric_oxide synthase levels in human ovarian_cancer cells : involvement in p53 regulation and cisplatin resistance .
20381264	0	nitric_oxide	20,32	p53	146,149	nitric oxide	p53	MESH:D009569	7157	Chemical	Gene	radicals|amod|START_ENTITY effects|nmod|radicals aberrations|nsubj|effects aberrations|nmod|cells cells|acl|carrying carrying|dobj|status status|compound|END_ENTITY	Biphasic effects of nitric_oxide radicals on radiation-induced lethality and chromosome aberrations in human lung_cancer cells carrying different p53 gene status .
23125026	0	nitric_oxide	9,21	p53	95,98	nitric oxide	p53	MESH:D009569	7157	Chemical	Gene	delivery|compound|START_ENTITY induces|nsubj|delivery induces|dobj|chemosensitivity chemosensitivity|nmod|END_ENTITY	Targeted nitric_oxide delivery preferentially induces glioma cell chemosensitivity via altered p53 and O -LRB- 6 -RRB- _ - methylguanine-DNA_methyltransferase activity .
23454130	0	nitric_oxide	90,102	p53	44,47	nitric oxide	p53	MESH:D009569	22060(Tax:10090)	Chemical	Gene	production|compound|START_ENTITY downregulates|dobj|production downregulates|nsubj|Pifithrin-a Pifithrin-a|appos|inhibitor inhibitor|nmod|END_ENTITY	Pifithrin-a , a pharmacological inhibitor of p53 , downregulates lipopolysaccharide-induced nitric_oxide production via impairment of the MyD88-independent pathway .
8634091	0	nitric_oxide	49,61	p53	13,16	nitric oxide	p53	MESH:D009569	7157	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Induction of p53 and p21/WAF1/CIP1 expression by nitric_oxide and their association with apoptosis in human cancer cells .
8954910	0	nitric_oxide	23,35	p53	57,60	nitric oxide	p53	MESH:D009569	7157	Chemical	Gene	accumulation|compound|START_ENTITY accumulation|compound|END_ENTITY	Cytokine and low-level nitric_oxide prestimulation block p53 accumulation and apoptosis of RAW 264.7 macrophages .
9671763	0	nitric_oxide	27,39	p53	76,79	nitric oxide	p53	MESH:D009569	22060(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|expression expression|nmod|mice mice|compound|END_ENTITY	Up-regulation of inducible nitric_oxide synthase expression in cancer-prone p53 knockout mice .
12821676	0	nitric_oxide	75,87	p75NTR	52,58	nitric oxide	p75NTR	MESH:D009569	4804	Chemical	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Osmotic swelling induces p75_neurotrophin_receptor -LRB- p75NTR -RRB- expression via nitric_oxide .
12821676	0	nitric_oxide	75,87	p75_neurotrophin_receptor	25,50	nitric oxide	p75 neurotrophin receptor	MESH:D009569	4804	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Osmotic swelling induces p75_neurotrophin_receptor -LRB- p75NTR -RRB- expression via nitric_oxide .
15572519	0	nitric_oxide	54,66	phospholipase_D	120,135	nitric oxide	phospholipase D	MESH:D009569	2822	Chemical	Gene	mechanism|amod|START_ENTITY mechanism|acl|resulting resulting|nmod|activity activity|amod|END_ENTITY	AT2 receptors cross talk with AT1 receptors through a nitric_oxide - and RhoA-dependent mechanism resulting in decreased phospholipase_D activity .
20951469	0	nitric_oxide	141,153	phospholipase_D	73,88	nitric oxide	phospholipase D	MESH:D009569	543819(Tax:4081)	Chemical	Gene	requires|xcomp|START_ENTITY requires|nsubj|production production|nmod|kinase kinase|amod|END_ENTITY	Phosphatidic_acid production in chitosan-elicited tomato cells , via both phospholipase_D and phospholipase C/diacylglycerol _ kinase , requires nitric_oxide .
22108610	0	nitric_oxide	95,107	pituitary_adenylate_cyclase-activating_peptide	47,93	nitric oxide	pituitary adenylate cyclase-activating peptide	MESH:D009569	24166(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY synthase|amod|END_ENTITY	Distribution of vasoactive intestinal peptide , pituitary_adenylate_cyclase-activating_peptide , nitric_oxide synthase , and their receptors in human and rat sphenopalatine ganglion .
24695088	0	nitric_oxide	80,92	plasmin	69,76	nitric oxide	plasmin	MESH:D009569	5340	Chemical	Gene	synthesis|amod|START_ENTITY END_ENTITY|nmod|synthesis	Estriol-induced fibrinolysis due to the activation of plasminogen to plasmin by nitric_oxide synthesis in platelets .
10672008	0	nitric_oxide	27,39	plasminogen_activator_inhibitor_type_1	43,81	nitric oxide	plasminogen activator inhibitor type 1	MESH:D009569	5054	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|amod|END_ENTITY	Dual regulatory effects of nitric_oxide on plasminogen_activator_inhibitor_type_1 expression in endothelial cells .
17949955	0	nitric_oxide	106,118	plasminogen_activator_inhibitor_type_1	54,92	nitric oxide	plasminogen activator inhibitor type 1	MESH:D009569	5054	Chemical	Gene	START_ENTITY|nsubj|study study|nmod|action action|nmod|supplementation supplementation|nmod|END_ENTITY	A study on the action of vitamin_E supplementation on plasminogen_activator_inhibitor_type_1 and platelet nitric_oxide production in type 2 diabetic patients .
10788422	0	nitric_oxide	29,41	prolactin	74,83	nitric oxide	prolactin	MESH:D009569	5617	Chemical	Gene	synthase|amod|START_ENTITY synthase|acl|inducing inducing|nmod|END_ENTITY	Proteolytic cleavage confers nitric_oxide synthase inducing activity upon prolactin .
11306175	0	nitric_oxide	12,24	prolactin	55,64	nitric oxide	prolactin	MESH:D009569	5617	Chemical	Gene	role|nmod|START_ENTITY role|nmod|activity activity|nmod|END_ENTITY	The role of nitric_oxide in the biological activity of prolactin in the mouse mammary gland .
16140971	0	nitric_oxide	42,54	prolactin	7,16	nitric oxide	prolactin	MESH:D009569	5617	Chemical	Gene	expression|amod|START_ENTITY inducible|dobj|expression inducible|nsubj|down-regulates down-regulates|compound|END_ENTITY	16-kDa prolactin down-regulates inducible nitric_oxide synthase expression through inhibition of the signal_transducer_and_activator_of_transcription_1 / IFN regulatory factor-1 pathway .
7489321	0	nitric_oxide	14,26	prolactin	86,95	nitric oxide	prolactin	MESH:D009569	24683(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY Inhibition|nmod|synthase blocks|nsubj|Inhibition blocks|dobj|increase increase|nmod|END_ENTITY	Inhibition of nitric_oxide synthase in the hypothalamus blocks the increase in plasma prolactin induced by intraventricular injection of interleukin-1_alpha in the rat .
7827997	0	nitric_oxide	23,35	prolactin	78,87	nitric oxide	prolactin	MESH:D009569	24683(Tax:10116)	Chemical	Gene	involvement|amod|START_ENTITY involvement|nmod|release release|nmod|END_ENTITY	Evidence in support of nitric_oxide -LRB- NO -RRB- involvement in the cyclic release of prolactin and LH surges .
8742019	0	nitric_oxide	11,23	prolactin	84,93	nitric oxide	prolactin	MESH:D009569	24683(Tax:10116)	Chemical	Gene	donors|amod|START_ENTITY Effects|nmod|donors Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of nitric_oxide donors sodium_nitroprusside and 3-morpholino-sydnonimine on prolactin secretion in conscious rats .
8880220	0	nitric_oxide	110,122	prolactin	18,27	nitric oxide	prolactin	MESH:D009569	5617	Chemical	Gene	role|nmod|START_ENTITY induces|parataxis|role induces|nsubj|END_ENTITY	Recombinant human prolactin induces protection against Salmonella_typhimurium infection in the mouse : role of nitric_oxide .
9711981	0	nitric_oxide	15,27	prolactin	72,81	nitric oxide	prolactin	MESH:D009569	5617	Chemical	Gene	Involvement|nmod|START_ENTITY intestinal|nsubj|Involvement intestinal|dobj|secretion secretion|compound|END_ENTITY	Involvement of nitric_oxide in vasoactive intestinal peptide-stimulated prolactin secretion in normal men .
18483407	0	nitric_oxide	26,38	proline-rich_tyrosine_kinase_2	60,90	nitric oxide	proline-rich tyrosine kinase 2	MESH:D009569	19229(Tax:10090)	Chemical	Gene	Inhibition|nmod|START_ENTITY synthase|nsubj|Inhibition synthase|nmod|stress stress|amod|END_ENTITY	Inhibition of endothelial nitric_oxide synthase activity by proline-rich_tyrosine_kinase_2 in response to fluid shear stress and insulin .
18981321	0	nitric_oxide	136,148	proline-rich_tyrosine_kinase_2	38,68	nitric oxide	proline-rich tyrosine kinase 2	MESH:D009569	50646(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY promote|dobj|phosphorylation activates|xcomp|promote activates|dobj|complex complex|amod|END_ENTITY	Dietary salt activates an endothelial proline-rich_tyrosine_kinase_2 / c-Src/phosphatidylinositol 3-kinase complex to promote endothelial nitric_oxide synthase phosphorylation .
10834941	0	nitric_oxide	65,77	prostaglandin_endoperoxide_H_synthase-2	14,53	nitric oxide	prostaglandin endoperoxide H synthase-2	MESH:D009569	19225(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Expression of prostaglandin_endoperoxide_H_synthase-2 induced by nitric_oxide in conditionally immortalized murine colonic epithelial cells .
19064940	0	nitric_oxide	53,65	protease-activated_receptor-1	8,37	nitric oxide	protease-activated receptor-1	MESH:D009569	2149	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of protease-activated_receptor-1 in endothelial nitric_oxide synthase-Thr495 phosphorylation .
14613873	0	nitric_oxide	6,18	protease-activated_receptor_2	70,99	nitric oxide	protease-activated receptor 2	MESH:D009569	116677(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|effects effects|nmod|END_ENTITY	Basal nitric_oxide modulates vascular effects of a peptide activating protease-activated_receptor_2 .
11951115	0	nitric_oxide	45,57	protein_kinase_C	11,27	nitric oxide	protein kinase C	MESH:D009569	24681(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY inhibition|nmod|synthesis END_ENTITY|nmod|inhibition	-LSB- Effect of protein_kinase_C on inhibition of nitric_oxide synthesis in cultured neonatal rat cardiomyocytes by angiotensin_II -RSB- .
10803407	0	nitric_oxide	67,79	protein_kinase_C-alpha	97,119	nitric oxide	protein kinase C-alpha	MESH:D009569	5578	Chemical	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	Activation of platelet-activating_factor _ -LRB- PAF -RRB- _ receptor stimulates nitric_oxide -LRB- NO -RRB- release via protein_kinase_C-alpha in HEC-1B human endometrial epithelial cell line .
19809279	0	nitric_oxide	63,75	protein_kinase_C-delta	110,132	nitric oxide	protein kinase C-delta	MESH:D009569	100726624	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Aprotinin abolishes sevoflurane postconditioning by inhibiting nitric_oxide production and phosphorylation of protein_kinase_C-delta and glycogen_synthase_kinase_3beta .
14505805	0	nitric_oxide	124,136	protein_kinase_Cdelta	15,36	nitric oxide	protein kinase Cdelta	MESH:D009569	5580	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Involvement of protein_kinase_Cdelta and extracellular signal-regulated kinase-2 in the suppression of microglial inducible nitric_oxide synthase expression by N - -LSB- 3,4-dimethoxycinnamoyl -RSB- - anthranilic_acid -LRB- tranilast -RRB- .
10352298	0	nitric_oxide	99,111	protein_tyrosine_phosphatase	23,51	nitric oxide	protein tyrosine phosphatase	MESH:D009569	26191	Chemical	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Negative regulation by protein_tyrosine_phosphatase of IFN-gamma-dependent expression of inducible nitric_oxide synthase .
23875749	0	nitric_oxide	25,37	rac2	52,56	nitric oxide	rac2	MESH:D009569	5880	Chemical	Gene	synthase|compound|START_ENTITY synthase|nmod|END_ENTITY	Interaction of inducible nitric_oxide synthase with rac2 regulates reactive oxygen and nitrogen species generation in the human neutrophil phagosomes : implication in microbial killing .
21331324	0	nitric_oxide	40,52	reelin	20,26	nitric oxide	reelin	MESH:D009569	19699(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY synthase|compound|END_ENTITY	The coexpression of reelin and neuronal nitric_oxide synthase in a subpopulation of dentate gyrus neurons is downregulated in heterozygous reeler mice .
10510146	0	nitric_oxide	14,26	renin	45,50	nitric oxide	renin	MESH:D009569	5972	Chemical	Gene	effect|nmod|START_ENTITY inhibition|nsubj|effect inhibition|nmod|response response|amod|END_ENTITY	The effect of nitric_oxide inhibition on the renin response to frusemide , in man .
10513831	0	nitric_oxide	22,34	renin	48,53	nitric oxide	renin	MESH:D009569	5972	Chemical	Gene	synthesis|amod|START_ENTITY synthesis|nmod|secretion secretion|compound|END_ENTITY	Effect of blockade of nitric_oxide synthesis on renin secretion in human subjects .
12646409	0	nitric_oxide	78,90	renin	27,32	nitric oxide	renin	MESH:D009569	24715(Tax:10116)	Chemical	Gene	independent|nmod|START_ENTITY independent|nsubj|stimulation stimulation|nmod|END_ENTITY	Sympathetic stimulation of renin is independent of direct regulation by renal nitric_oxide .
23302571	0	nitric_oxide	163,175	renin	100,105	nitric oxide	renin	MESH:D009569	24715(Tax:10116)	Chemical	Gene	-RSB-|amod|START_ENTITY levels|nmod|-RSB- levels|compound|END_ENTITY	-LSB- Adenosine receptors agonists mitigated PAH of rats induced by chronic hypoxia through reduction of renin activity/angiotensin _ II levels and increase of inducible nitric_oxide synthase-nitric_oxide levels -RSB- .
24473199	0	nitric_oxide	109,121	renin	7,12	nitric oxide	renin	MESH:D009569	24715(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY activating|dobj|synthase injury|dep|activating injury|dep|protects protects|nsubj|inhibition inhibition|compound|END_ENTITY	Direct renin inhibition with aliskiren protects against myocardial_ischemia / reperfusion injury by activating nitric_oxide synthase signaling in spontaneously hypertensive rats .
7534728	0	nitric_oxide	8,20	renin	42,47	nitric oxide	renin	MESH:D009569	5972	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|regulation regulation|nmod|secretion secretion|compound|END_ENTITY	Role of nitric_oxide in the regulation of renin and vasopressin secretion .
7538649	0	nitric_oxide	44,56	renin	105,110	nitric oxide	renin	MESH:D009569	24715(Tax:10116)	Chemical	Gene	formation|nmod|START_ENTITY induces|dobj|formation induces|parataxis|influence influence|nmod|secretion secretion|compound|END_ENTITY	Interleukin-1_beta induces the formation of nitric_oxide in isolated juxtaglomerular cells : influence on renin secretion .
7543251	0	nitric_oxide	19,31	renin	81,86	nitric oxide	renin	MESH:D009569	24715(Tax:10116)	Chemical	Gene	inhibition|amod|START_ENTITY blocks|nsubj|inhibition blocks|dobj|secretion secretion|compound|END_ENTITY	Selective neuronal nitric_oxide synthase inhibition blocks furosemide-stimulated renin secretion in vivo .
7543251	2	nitric_oxide	203,215	renin	262,267	nitric oxide	renin	MESH:D009569	24715(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY isoform|nmod|synthase contains|dobj|isoform contains|advcl|suggesting suggesting|ccomp|stimulate stimulate|dobj|secretion secretion|compound|END_ENTITY	It contains exclusively the neuronal isoform of nitric_oxide synthase -LRB- NOS -RRB- , suggesting NO could stimulate renin secretion through the macula densa pathway .
7543396	0	nitric_oxide	22,34	renin	52,57	nitric oxide	renin	MESH:D009569	100358545(Tax:9986)	Chemical	Gene	synthesis|amod|START_ENTITY synthesis|nmod|response response|compound|END_ENTITY	Effect of blockade of nitric_oxide synthesis on the renin secretory response to frusemide in conscious rabbits .
7644529	0	nitric_oxide	46,58	renin	21,26	nitric oxide	renin	MESH:D009569	24715(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Tonic stimulation of renin gene expression by nitric_oxide is counteracted by tonic inhibition through angiotensin_II .
7771523	0	nitric_oxide	10,22	renin	26,31	nitric oxide	renin	MESH:D009569	5972	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of nitric_oxide on renin secretion .
7771524	0	nitric_oxide	10,22	renin	26,31	nitric oxide	renin	MESH:D009569	100358545(Tax:9986)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of nitric_oxide on renin secretion .
8258672	0	nitric_oxide	48,60	renin	104,109	nitric oxide	renin	MESH:D009569	24715(Tax:10116)	Chemical	Gene	formation|amod|START_ENTITY inhibition|nmod|formation inhibition|dep|role role|nmod|hypertrophy hypertrophy|compound|END_ENTITY	Persistent hypertension following inhibition of nitric_oxide formation in the young Wistar rat : role of renin and vascular hypertrophy .
8282375	0	nitric_oxide	8,20	renin	28,33	nitric oxide	renin	MESH:D009569	100358545(Tax:9986)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of nitric_oxide in the renin and heart rate responses to beta-adrenergic stimulation .
8352025	0	nitric_oxide	44,56	renin	10,15	nitric oxide	renin	MESH:D009569	403838(Tax:9615)	Chemical	Gene	synthesis|compound|START_ENTITY inhibiting|dobj|synthesis release|acl|inhibiting release|compound|END_ENTITY	Effect on renin release of inhibiting renal nitric_oxide synthesis in anaesthetized dogs .
8648902	0	nitric_oxide	46,58	renin	14,19	nitric oxide	renin	MESH:D009569	24715(Tax:10116)	Chemical	Gene	inhibition|amod|START_ENTITY impaired|nmod|inhibition impaired|nsubjpass|Regulation Regulation|nmod|release release|compound|END_ENTITY	Regulation of renin release is impaired after nitric_oxide inhibition .
8662293	0	nitric_oxide	12,24	renin	67,72	nitric oxide	renin	MESH:D009569	24715(Tax:10116)	Chemical	Gene	formation|amod|START_ENTITY Blockade|nmod|formation inhibits|nsubj|Blockade inhibits|dobj|stimulation stimulation|nmod|system system|compound|END_ENTITY	Blockade of nitric_oxide formation inhibits the stimulation of the renin system by a low salt intake .
8901817	0	nitric_oxide	60,72	renin	19,24	nitric oxide	renin	MESH:D009569	24715(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY blockade|nmod|synthase release|nmod|blockade release|nsubj|END_ENTITY	Pressure-dependent renin release during chronic blockade of nitric_oxide synthase .
9176324	0	nitric_oxide	82,94	renin	28,33	nitric oxide	renin	MESH:D009569	24715(Tax:10116)	Chemical	Gene	synthase|compound|START_ENTITY inhibition|nmod|synthase reversed|nmod|inhibition reversed|nsubjpass|stimulation stimulation|nmod|END_ENTITY	Macula densa stimulation of renin is reversed by selective inhibition of neuronal nitric_oxide synthase .
9186867	0	nitric_oxide	53,65	renin	14,19	nitric oxide	renin	MESH:D009569	24715(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY dependent|nmod|production dependent|nsubj|Activation Activation|nmod|synthesis synthesis|compound|END_ENTITY	Activation of renin synthesis is dependent on intact nitric_oxide production .
9539809	0	nitric_oxide	34,46	renin	15,20	nitric oxide	renin	MESH:D009569	24715(Tax:10116)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Stimulation of renin secretion by nitric_oxide is mediated by phosphodiesterase 3 .
9843901	0	nitric_oxide	8,20	renin	39,44	nitric oxide	renin	MESH:D009569	5972	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|control control|nmod|secretion secretion|compound|END_ENTITY	Role of nitric_oxide in the control of renin secretion .
18339647	0	nitric_oxide	51,63	sGCalpha1	67,76	nitric oxide	sGCalpha1	MESH:D009569	60596(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Gender-specific hypertension and responsiveness to nitric_oxide in sGCalpha1 knockout mice .
22434701	0	nitric_oxide	14,26	salivary_peroxidase	36,55	nitric oxide	salivary peroxidase	MESH:D009569	4025	Chemical	Gene	Production|nmod|START_ENTITY Production|nmod|END_ENTITY	Production of nitric_oxide by human salivary_peroxidase and by bovine lactoperoxidase .
17452640	0	nitric_oxide	68,80	serotonin_transporter	33,54	nitric oxide	serotonin transporter	MESH:D009569	6532	Chemical	Gene	synthase|compound|START_ENTITY synthase|amod|END_ENTITY	Physical interaction between the serotonin_transporter and neuronal nitric_oxide synthase underlies reciprocal modulation of their activity .
17097687	0	nitric_oxide	10,22	signal_transducer_and_activator_of_transcription_3	50,100	nitric oxide	signal transducer and activator of transcription 3	MESH:D009569	20848(Tax:10090)	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|activation activation|amod|END_ENTITY	Excessive nitric_oxide attenuates leptin-mediated signal_transducer_and_activator_of_transcription_3 activation .
18396380	0	nitric_oxide	21,33	slug	62,66	nitric oxide	slug	MESH:D009569	6591	Chemical	Gene	synthase|amod|START_ENTITY synthase|nmod|END_ENTITY	Genomic structure of nitric_oxide synthase in the terrestrial slug is highly conserved .
13678534	0	nitric_oxide	24,36	soluble_guanylate_cyclase	55,80	nitric oxide	soluble guanylate cyclase	MESH:D009569	25206(Tax:10116)	Chemical	Gene	utilization|nmod|START_ENTITY utilization|nmod|END_ENTITY	Aberrant utilization of nitric_oxide and regulation of soluble_guanylate_cyclase in rat diabetic_retinopathy .
15377279	0	nitric_oxide	182,194	soluble_guanylate_cyclase	128,153	nitric oxide	soluble guanylate cyclase	MESH:D009569	25206(Tax:10116)	Chemical	Gene	formation|nmod|START_ENTITY mitochondrial|nmod|formation mitochondrial|dobj|bioactivation bioactivation|dep|evidence evidence|nmod|activation activation|nmod|END_ENTITY	Contribution of aldehyde dehydrogenase to mitochondrial bioactivation of nitroglycerin : evidence for the activation of purified soluble_guanylate_cyclase through direct formation of nitric_oxide .
17300699	0	nitric_oxide	19,31	soluble_guanylate_cyclase	58,83	nitric oxide	soluble guanylate cyclase	MESH:D009569	25206(Tax:10116)	Chemical	Gene	interaction|compound|START_ENTITY interaction|nmod|END_ENTITY	Increased neuronal nitric_oxide synthase interaction with soluble_guanylate_cyclase contributes to the splanchnic_arterial_vasodilation in portal hypertensive rats .
19427360	0	nitric_oxide	19,31	soluble_guanylate_cyclase	126,151	nitric oxide	soluble guanylate cyclase	MESH:D009569	25206(Tax:10116)	Chemical	Gene	donor|compound|START_ENTITY NOC-9|appos|donor induces|nsubj|NOC-9 induces|advcl|activating activating|dobj|END_ENTITY	NOC-9 , a selective nitric_oxide donor , induces flight reactions in the dorsolateral periaqueductal gray of rats by activating soluble_guanylate_cyclase .
9124595	0	nitric_oxide	39,51	soluble_guanylate_cyclase	10,35	nitric oxide	soluble guanylate cyclase	MESH:D009569	25206(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY END_ENTITY|appos|receptor	Pulmonary soluble_guanylate_cyclase , a nitric_oxide receptor , is increased during the perinatal period .
9836582	0	nitric_oxide	71,83	soluble_guanylate_cyclase	36,61	nitric oxide	soluble guanylate cyclase	MESH:D009569	25206(Tax:10116)	Chemical	Gene	complex|amod|START_ENTITY END_ENTITY|nmod|complex	Regeneration of the ferrous heme of soluble_guanylate_cyclase from the nitric_oxide complex : acceleration by thiols and oxyhemoglobin .
10419542	0	nitric_oxide	129,141	soluble_guanylyl_cyclase	4,28	nitric oxide	soluble guanylyl cyclase	MESH:D009569	497757(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY inhibitor|nmod|synthase inhibitor|parataxis|inhibitor inhibitor|nsubj|END_ENTITY	The soluble_guanylyl_cyclase inhibitor 1H - -LSB- 1,2,4 -RSB- oxadiazolo -LSB- 4,3,-a -RSB- _ quinoxalin-1-one is a nonselective heme protein inhibitor of nitric_oxide synthase and other cytochrome_P-450 enzymes involved in nitric_oxide donor bioactivation .
10578147	0	nitric_oxide	11,23	soluble_guanylyl_cyclase	83,107	nitric oxide	soluble guanylyl cyclase	MESH:D009569	497757(Tax:10116)	Chemical	Gene	Release|nmod|START_ENTITY stimulated|nsubj|Release stimulated|nmod|YC-1 YC-1|appos|activator activator|nmod|END_ENTITY	Release of nitric_oxide from endothelial cells stimulated by YC-1 , an activator of soluble_guanylyl_cyclase .
11168561	0	nitric_oxide	16,28	soluble_guanylyl_cyclase	39,63	nitric oxide	soluble guanylyl cyclase	MESH:D009569	25206(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Subunits of the nitric_oxide receptor , soluble_guanylyl_cyclase , expressed in rat brain .
11976273	0	nitric_oxide	20,32	soluble_guanylyl_cyclase	43,67	nitric oxide	soluble guanylyl cyclase	MESH:D009569	497757(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Pharmacology of the nitric_oxide receptor , soluble_guanylyl_cyclase , in cerebellar cells .
12231239	0	nitric_oxide	53,65	soluble_guanylyl_cyclase	76,100	nitric oxide	soluble guanylyl cyclase	MESH:D009569	497757(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Regional distribution of protein and activity of the nitric_oxide receptor , soluble_guanylyl_cyclase , in rat brain suggests multiple mechanisms of regulation .
15175556	0	nitric_oxide	21,33	soluble_guanylyl_cyclase	94,118	nitric oxide	soluble guanylyl cyclase	MESH:D009569	497757(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Sustaining excessive nitric_oxide upregulates protein expression of nitric_oxide synthase via soluble_guanylyl_cyclase : an in vivo study in rats .
15175556	0	nitric_oxide	68,80	soluble_guanylyl_cyclase	94,118	nitric oxide	soluble guanylyl cyclase	MESH:D009569	497757(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY expression|nmod|synthase expression|nmod|END_ENTITY	Sustaining excessive nitric_oxide upregulates protein expression of nitric_oxide synthase via soluble_guanylyl_cyclase : an in vivo study in rats .
20639220	0	nitric_oxide	119,131	soluble_guanylyl_cyclase	52,76	nitric oxide	soluble guanylyl cyclase	MESH:D009569	25206(Tax:10116)	Chemical	Gene	modulated|nmod|START_ENTITY modulated|nsubjpass|responses responses|nmod|stimulator stimulator|amod|END_ENTITY	Pulmonary and systemic vasodilator responses to the soluble_guanylyl_cyclase stimulator , BAY_41-8543 , are modulated by nitric_oxide .
21217076	0	nitric_oxide	133,145	soluble_guanylyl_cyclase	52,76	nitric oxide	soluble guanylyl cyclase	MESH:D009569	497757(Tax:10116)	Chemical	Gene	dependent|nmod|START_ENTITY dependent|nsubj|responses responses|nmod|activator activator|amod|END_ENTITY	Pulmonary and systemic vasodilator responses to the soluble_guanylyl_cyclase activator , BAY_60-2770 , are not dependent on endogenous nitric_oxide or reduced heme .
22171090	0	nitric_oxide	38,50	soluble_guanylyl_cyclase	72,96	nitric oxide	soluble guanylyl cyclase	MESH:D009569	25206(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY coactivators|nmod|receptor coactivators|acl:relcl|target target|dobj|domain domain|amod|END_ENTITY	Cobinamides are novel coactivators of nitric_oxide receptor that target soluble_guanylyl_cyclase catalytic domain .
26917471	0	nitric_oxide	77,89	soluble_guanylyl_cyclase	47,71	nitric oxide	soluble guanylyl cyclase	MESH:D009569	497757(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY END_ENTITY|appos|receptor	Identification of novel S-nitrosation sites in soluble_guanylyl_cyclase , the nitric_oxide receptor .
8643658	0	nitric_oxide	51,63	soluble_guanylyl_cyclase	104,128	nitric oxide	soluble guanylyl cyclase	MESH:D009569	25206(Tax:10116)	Chemical	Gene	actions|nmod|START_ENTITY actions|dep|confirmation confirmation|acl|using using|dobj|inhibitor inhibitor|nmod|END_ENTITY	cGMP mediates the vascular and platelet actions of nitric_oxide : confirmation using an inhibitor of the soluble_guanylyl_cyclase .
15544848	0	nitric_oxide	74,86	somatostatin	48,60	nitric oxide	somatostatin	MESH:D009569	24797(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY increases|nmod|release increases|dobj|mRNA mRNA|compound|END_ENTITY	Endotoxin administration increases hypothalamic somatostatin mRNA through nitric_oxide release .
10847630	0	nitric_oxide	8,20	stat3	43,48	nitric oxide	stat3	MESH:D009569	6774	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	Induced nitric_oxide inhibits IL-6-induced stat3 activation and type II acute phase mRNA expression .
17276712	0	nitric_oxide	56,68	stromal_cell-derived_factor-1	14,43	nitric oxide	stromal cell-derived factor-1	MESH:D009569	6387	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of stromal_cell-derived_factor-1 and exhaled nitric_oxide in asthmatic children following montelukast and ketotifen treatment .
16955242	0	nitric_oxide	29,41	substance_P	14,25	nitric oxide	substance P	MESH:D009569	21333(Tax:10090)	Chemical	Gene	release|amod|START_ENTITY effect|nmod|release effect|nmod|END_ENTITY	The effect of substance_P on nitric_oxide release in a rheumatoid_arthritis model .
17178379	0	nitric_oxide	29,41	substance_P	14,25	nitric oxide	substance P	MESH:D009569	6863	Chemical	Gene	production|amod|START_ENTITY effect|nmod|production effect|nmod|END_ENTITY	The effect of substance_P on nitric_oxide production by HSV-1 infected macrophages .
8655420	0	nitric_oxide	44,56	substance_P	67,78	nitric oxide	substance P	MESH:D009569	6863	Chemical	Gene	synthase|amod|START_ENTITY Localisation|appos|synthase Localisation|appos|END_ENTITY	Localisation of immunoreactive factor VIII , nitric_oxide synthase , substance_P , endothelin-1_and_5-hydroxytryptamine in human postmortem middle cerebral artery .
9059312	0	nitric_oxide	8,20	substance_P	52,63	nitric oxide	substance P	MESH:D009569	6863	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|effects effects|nmod|END_ENTITY	Role of nitric_oxide towards vasodilator effects of substance_P and ATP in human forearm vessels .
9059313	0	nitric_oxide	87,99	substance_P	40,51	nitric oxide	substance P	MESH:D009569	6863	Chemical	Gene	contribution|nmod|START_ENTITY Comparison|dep|contribution Comparison|nmod|vasodilatation vasodilatation|nmod|END_ENTITY	Comparison of forearm vasodilatation to substance_P and acetylcholine : contribution of nitric_oxide .
11283520	0	nitric_oxide	10,22	thrombopoietin	58,72	nitric oxide	thrombopoietin	MESH:D009569	7066	Chemical	Gene	Effect|nmod|START_ENTITY induced|nsubj|Effect induced|nmod|END_ENTITY	Effect of nitric_oxide on megakaryocyte growth induced by thrombopoietin .
18068687	0	nitric_oxide	133,145	thrombospondin-1	94,110	nitric oxide	thrombospondin-1	MESH:D009569	7057	Chemical	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Differential effects of ABT-510 and a CD36-binding peptide derived from the type 1 repeats of thrombospondin-1 on fatty_acid uptake , nitric_oxide signaling , and caspase activation in vascular cells .
19194382	0	nitric_oxide	14,26	thrombospondin_1	41,57	nitric oxide	thrombospondin 1	MESH:D009569	7057	Chemical	Gene	START_ENTITY|acl|signalling signalling|nmod|END_ENTITY	Regulation of nitric_oxide signalling by thrombospondin_1 : implications for anti-angiogenic therapies .
25271630	0	nitric_oxide	86,98	thymosin_beta-4	31,46	nitric oxide	thymosin beta-4	MESH:D009569	19241(Tax:10090)	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	The actin-sequestering protein thymosin_beta-4 is a novel target of hypoxia-inducible nitric_oxide and HIF-1a regulation .
9537833	0	nitric_oxide	102,114	tissue-type_plasminogen_activator	26,59	nitric oxide	tissue-type plasminogen activator	MESH:D009569	25692(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY regulation|nmod|production Role|nmod|regulation Role|nmod|END_ENTITY	Role of astrocyte-derived tissue-type_plasminogen_activator in the regulation of endotoxin-stimulated nitric_oxide production by microglial cells .
7540059	0	nitric_oxide	11,23	transforming_growth_factor-beta	47,78	nitric oxide	transforming growth factor-beta	MESH:D009569	7040	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Control of nitric_oxide synthase expression by transforming_growth_factor-beta : implications for homeostasis .
10342487	0	nitric_oxide	10,22	transforming_growth_factor-beta1	52,84	nitric oxide	transforming growth factor-beta1	MESH:D009569	7040	Chemical	Gene	START_ENTITY|dobj|production production|nmod|END_ENTITY	Inducible nitric_oxide production and expression of transforming_growth_factor-beta1 in serum and CSF after cerebral ischaemic_stroke in man .
10362813	0	nitric_oxide	24,36	transforming_growth_factor-beta1	64,96	nitric oxide	transforming growth factor-beta1	MESH:D009569	59086(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY synthesis|nmod|END_ENTITY	Evidence for control of nitric_oxide synthesis by intracellular transforming_growth_factor-beta1 in tumor cells .
10534444	0	nitric_oxide	11,23	transforming_growth_factor-beta1	63,95	nitric oxide	transforming growth factor-beta1	MESH:D009569	21803(Tax:10090)	Chemical	Gene	production|compound|START_ENTITY production|nmod|administration administration|nmod|END_ENTITY	Diminished nitric_oxide production following administration of transforming_growth_factor-beta1 using a noninflammatory wound repair model .
10642280	0	nitric_oxide	113,125	transforming_growth_factor-beta1	8,40	nitric oxide	transforming growth factor-beta1	MESH:D009569	59086(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY inhibition|nmod|synthesis induced|nmod|inhibition induced|nsubj|Role Role|nmod|END_ENTITY	Role of transforming_growth_factor-beta1 in cardiovascular inflammatory changes induced by chronic inhibition of nitric_oxide synthesis .
11994256	0	nitric_oxide	60,72	transforming_growth_factor-beta1	102,134	nitric oxide	transforming growth factor-beta1	MESH:D009569	59086(Tax:10116)	Chemical	Gene	injury|nmod|START_ENTITY myocytes|nmod|injury Protection|nmod|myocytes mediated|nsubjpass|Protection mediated|nmod|modulation modulation|nmod|END_ENTITY	Protection of myocytes from hypoxia-reoxygenation injury by nitric_oxide is mediated by modulation of transforming_growth_factor-beta1 .
15838489	0	nitric_oxide	90,102	transforming_growth_factor-beta1	18,50	nitric oxide	transforming growth factor-beta1	MESH:D009569	7040	Chemical	Gene	synthesis|nmod|START_ENTITY correlates|nmod|synthesis correlates|amod|END_ENTITY	Overexpression of transforming_growth_factor-beta1 correlates with increased synthesis of nitric_oxide synthase in varicose veins .
9701040	0	nitric_oxide	11,23	transforming_growth_factor-beta1	38,70	nitric oxide	transforming growth factor-beta1	MESH:D009569	7040	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Control of nitric_oxide production by transforming_growth_factor-beta1 : mechanistic insights and potential relevance to human disease .
1282159	0	nitric_oxide	31,43	transforming_growth_factor-beta_1	58,91	nitric oxide	transforming growth factor-beta 1	MESH:D009569	7040	Chemical	Gene	production|compound|START_ENTITY Inhibition|nmod|production Inhibition|nmod|cells cells|amod|END_ENTITY	Inhibition of cytokine-induced nitric_oxide production by transforming_growth_factor-beta_1 in human smooth muscle cells .
7543000	0	nitric_oxide	52,64	transforming_growth_factor-beta_1	77,110	nitric oxide	transforming growth factor-beta 1	MESH:D009569	282089(Tax:9913)	Chemical	Gene	START_ENTITY|xcomp|synthase synthase|advcl|END_ENTITY	Molecular regulation of the bovine endothelial cell nitric_oxide synthase by transforming_growth_factor-beta_1 .
8769796	0	nitric_oxide	48,60	transforming_growth_factor-beta_1	11,44	nitric oxide	transforming growth factor-beta 1	MESH:D009569	7040	Chemical	Gene	synthesis|amod|START_ENTITY END_ENTITY|nmod|synthesis	Effects of transforming_growth_factor-beta_1 on nitric_oxide synthesis by C2C12 skeletal myocytes .
8979152	0	nitric_oxide	43,55	transforming_growth_factor-beta_1	69,102	nitric oxide	transforming growth factor-beta 1	MESH:D009569	59086(Tax:10116)	Chemical	Gene	synthesis|compound|START_ENTITY pleural|dobj|synthesis pleural|advcl|END_ENTITY	Inhibition of rat pleural mesothelial cell nitric_oxide synthesis by transforming_growth_factor-beta_1 .
10232601	0	nitric_oxide	50,62	transforming_growth_factor_beta1	14,46	nitric oxide	transforming growth factor beta1	MESH:D009569	7040	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of transforming_growth_factor_beta1 by nitric_oxide .
19657147	0	nitric_oxide	175,187	transforming_growth_factor_beta1	52,84	nitric oxide	transforming growth factor beta1	MESH:D009569	7040	Chemical	Gene	regulated|nmod|START_ENTITY proteins|acl:relcl|regulated synthesis|nmod|proteins causing|dobj|synthesis result|xcomp|causing result|nmod|induction induction|nmod|END_ENTITY	Increased TG2 expression can result in induction of transforming_growth_factor_beta1 , causing increased synthesis and deposition of matrix proteins , which can be regulated by nitric_oxide .
19657147	0	nitric_oxide	175,187	transforming_growth_factor_beta1	52,84	nitric oxide	transforming growth factor beta1	MESH:D009569	7040	Chemical	Gene	regulated|nmod|START_ENTITY proteins|acl:relcl|regulated synthesis|nmod|proteins causing|dobj|synthesis result|xcomp|causing result|nmod|induction induction|nmod|END_ENTITY	Increased TG2 expression can result in induction of transforming_growth_factor_beta1 , causing increased synthesis and deposition of matrix proteins , which can be regulated by nitric_oxide .
11380827	0	nitric_oxide	90,102	tumor_necrosis_factor	43,64	nitric oxide	tumor necrosis factor	MESH:D009569	21926(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY END_ENTITY|nmod|synthase	Endotoxemic renal_failure in mice : Role of tumor_necrosis_factor independent of inducible nitric_oxide synthase .
21356584	0	nitric_oxide	132,144	tumor_necrosis_factor-a	107,130	nitric oxide	tumor necrosis factor-a	MESH:D009569	280943(Tax:9913)	Chemical	Gene	oxidase|dep|START_ENTITY responses|amod|oxidase responses|amod|END_ENTITY	Modeling the effects of estradiol and progesterone on the acute phase proinflammatory axis : variability in tumor_necrosis_factor-a , nitric_oxide , and xanthine oxidase responses to endotoxin challenge in steers .
22117546	0	nitric_oxide	19,31	tumor_necrosis_factor-a	130,153	nitric oxide	tumor necrosis factor-a	MESH:D009569	7124	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of the nitric_oxide signaling system with the sphingomyelin cycle and peroxidation on transmission of toxic signal of tumor_necrosis_factor-a in ischemia-reperfusion .
10188770	0	nitric_oxide	164,176	tumor_necrosis_factor-alpha	178,205	nitric oxide	tumor necrosis factor-alpha	MESH:D009569	24835(Tax:10116)	Chemical	Gene	thromboxane_B2|dep|START_ENTITY thromboxane_B2|dep|END_ENTITY	Escherichia_coli lipopolysaccharide potentiation and inhibition of rat neonatal microglia superoxide anion generation : correlation with prior lactic dehydrogenase , nitric_oxide , tumor_necrosis_factor-alpha , thromboxane_B2 , and metalloprotease release .
10435033	0	nitric_oxide	8,20	tumor_necrosis_factor-alpha	86,113	nitric oxide	tumor necrosis factor-alpha	MESH:D009569	100135630(Tax:10141)	Chemical	Gene	factor|compound|START_ENTITY Role|nmod|factor induced|nsubj|Role induced|nmod|END_ENTITY	Role of nitric_oxide and platelet-activating factor in cardiac alterations induced by tumor_necrosis_factor-alpha in the guinea-pig papillary muscle .
10737256	0	nitric_oxide	53,65	tumor_necrosis_factor-alpha	78,105	nitric oxide	tumor necrosis factor-alpha	MESH:D009569	7124	Chemical	Gene	activation|nmod|START_ENTITY synthase|nsubj|activation synthase|nmod|END_ENTITY	Protein kinase C independent activation of inducible nitric_oxide synthase by tumor_necrosis_factor-alpha in TM4 Sertoli cells .
10865190	0	nitric_oxide	55,67	tumor_necrosis_factor-alpha	13,40	nitric oxide	tumor necrosis factor-alpha	MESH:D009569	21926(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY synthase|compound|END_ENTITY	Induction of tumor_necrosis_factor-alpha and inducible nitric_oxide synthase fails to prevent toxoplasmic_encephalitis in the absence of interferon-gamma in genetically resistant BALB/c mice .
10923398	0	nitric_oxide	95,107	tumor_necrosis_factor-alpha	44,71	nitric oxide	tumor necrosis factor-alpha	MESH:D009569	100009088(Tax:9986)	Chemical	Gene	immunoadsorption|nmod|START_ENTITY circulating|nmod|immunoadsorption circulating|dobj|END_ENTITY	-LSB- Effects of specific removal of circulating tumor_necrosis_factor-alpha by immunoadsorption on nitric_oxide in endotoxin shock -RSB- .
11399901	0	nitric_oxide	58,70	tumor_necrosis_factor-alpha	19,46	nitric oxide	tumor necrosis factor-alpha	MESH:D009569	24835(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY synthase|amod|END_ENTITY	The time course of tumor_necrosis_factor-alpha , inducible nitric_oxide synthase and vascular_endothelial_growth_factor expression in an experimental model of chronic myocardial_infarction in rats .
12003824	0	nitric_oxide	25,37	tumor_necrosis_factor-alpha	75,102	nitric oxide	tumor necrosis factor-alpha	MESH:D009569	21926(Tax:10090)	Chemical	Gene	Involvement|nmod|START_ENTITY synthase|nsubj|Involvement synthase|nmod|END_ENTITY	Involvement of inducible nitric_oxide synthase in cardiac_dysfunction with tumor_necrosis_factor-alpha .
12060397	0	nitric_oxide	10,22	tumor_necrosis_factor-alpha	114,141	nitric oxide	tumor necrosis factor-alpha	MESH:D009569	7124	Chemical	Gene	synthase|compound|START_ENTITY expressed|nsubjpass|synthase expressed|nmod|END_ENTITY	Inducible nitric_oxide synthase is expressed in normal human melanocytes but not in melanoma cells in response to tumor_necrosis_factor-alpha , interferon-gamma , and lipopolysaccharide .
12135128	0	nitric_oxide	10,22	tumor_necrosis_factor-alpha	132,159	nitric oxide	tumor necrosis factor-alpha	MESH:D009569	7124	Chemical	Gene	START_ENTITY|dep|correlation correlation|nmod|END_ENTITY	Increased nitric_oxide in proportion to the severity of heart_failure in patients with dilated_cardiomyopathy : close correlation of tumor_necrosis_factor-alpha with systemic and local production of nitric_oxide .
12135128	0	nitric_oxide	198,210	tumor_necrosis_factor-alpha	132,159	nitric oxide	tumor necrosis factor-alpha	MESH:D009569	7124	Chemical	Gene	correlation|nmod|START_ENTITY correlation|nmod|END_ENTITY	Increased nitric_oxide in proportion to the severity of heart_failure in patients with dilated_cardiomyopathy : close correlation of tumor_necrosis_factor-alpha with systemic and local production of nitric_oxide .
12356382	0	nitric_oxide	149,161	tumor_necrosis_factor-alpha	107,134	nitric oxide	tumor necrosis factor-alpha	MESH:D009569	7124	Chemical	Gene	synthase|compound|START_ENTITY synthase|compound|END_ENTITY	Relation of tissue Doppler-derived myocardial velocities to serum levels and myocardial gene expression of tumor_necrosis_factor-alpha and inducible nitric_oxide synthase in patients with ischemic_cardiomyopathy having coronary artery bypass grafting .
12399621	0	nitric_oxide	10,22	tumor_necrosis_factor-alpha	32,59	nitric oxide	tumor necrosis factor-alpha	MESH:D009569	7124	Chemical	Gene	inhibits|advmod|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Exogenous nitric_oxide inhibits tumor_necrosis_factor-alpha - or interleukin-1-beta-induced monocyte_chemoattractant_protein-1 expression in human mesangial cells .
12527339	0	nitric_oxide	57,69	tumor_necrosis_factor-alpha	15,42	nitric oxide	tumor necrosis factor-alpha	MESH:D009569	24835(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Suppression Suppression|nmod|END_ENTITY	Suppression of tumor_necrosis_factor-alpha and inducible nitric_oxide synthase gene expression by THI_52 , a new synthetic naphthyl-benzylisoquinoline_alkaloid .
12672181	0	nitric_oxide	23,35	tumor_necrosis_factor-alpha	128,155	nitric oxide	tumor necrosis factor-alpha	MESH:D009569	7124	Chemical	Gene	START_ENTITY|nmod|joints joints|nmod|transgenic_mice transgenic_mice|amod|END_ENTITY	Induction of inducible nitric_oxide synthase , argininosuccinate_synthase , and GTP_cyclohydrolase_I in arthritic joints of human tumor_necrosis_factor-alpha transgenic_mice .
12799216	0	nitric_oxide	104,116	tumor_necrosis_factor-alpha	23,50	nitric oxide	tumor necrosis factor-alpha	MESH:D009569	7124	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Undetectable levels of tumor_necrosis_factor-alpha , nitric_oxide and inadequate expression of inducible nitric_oxide synthase in congenital_hypothyroidism .
12799216	0	nitric_oxide	52,64	tumor_necrosis_factor-alpha	23,50	nitric oxide	tumor necrosis factor-alpha	MESH:D009569	7124	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Undetectable levels of tumor_necrosis_factor-alpha , nitric_oxide and inadequate expression of inducible nitric_oxide synthase in congenital_hypothyroidism .
15157956	0	nitric_oxide	12,24	tumor_necrosis_factor-alpha	61,88	nitric oxide	tumor necrosis factor-alpha	MESH:D009569	21926(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY synthases|nsubj|role synthases|nmod|END_ENTITY	The role of nitric_oxide synthases in the sleep responses to tumor_necrosis_factor-alpha .
16328964	0	nitric_oxide	74,86	tumor_necrosis_factor-alpha	38,65	nitric oxide	tumor necrosis factor-alpha	MESH:D009569	7124	Chemical	Gene	production|compound|START_ENTITY production|amod|END_ENTITY	Extracellular inosine participates in tumor_necrosis_factor-alpha induced nitric_oxide production in cultured Sertoli cells .
17466955	0	nitric_oxide	17,29	tumor_necrosis_factor-alpha	69,96	nitric oxide	tumor necrosis factor-alpha	MESH:D009569	21926(Tax:10090)	Chemical	Gene	Role|nmod|START_ENTITY synthase|nsubj|Role synthase|nmod|expression expression|amod|END_ENTITY	Role of neuronal nitric_oxide synthase in lipopolysaccharide-induced tumor_necrosis_factor-alpha expression in neonatal mouse cardiomyocytes .
18207479	0	nitric_oxide	37,49	tumor_necrosis_factor-alpha	82,109	nitric oxide	tumor necrosis factor-alpha	MESH:D009569	21926(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|inhalation inhalation|amod|END_ENTITY	Regulation of caveolin-1 expression , nitric_oxide production and tissue injury by tumor_necrosis_factor-alpha following ozone inhalation .
18449880	0	nitric_oxide	96,108	tumor_necrosis_factor-alpha	34,61	nitric oxide	tumor necrosis factor-alpha	MESH:D009569	21926(Tax:10090)	Chemical	Gene	burst|compound|START_ENTITY mediated|nmod|burst mediated|nsubjpass|activity activity|nmod|END_ENTITY	Tumoricidal activity of high-dose tumor_necrosis_factor-alpha is mediated by macrophage-derived nitric_oxide burst and permanent blood flow shutdown .
18475052	0	nitric_oxide	75,87	tumor_necrosis_factor-alpha	155,182	nitric oxide	tumor necrosis factor-alpha	MESH:D009569	21926(Tax:10090)	Chemical	Gene	glucagon-like_peptide-1|nmod|START_ENTITY production|amod|glucagon-like_peptide-1 effects|nmod|production mediated|nsubjpass|effects mediated|nmod|inhibition inhibition|nmod|production production|amod|END_ENTITY	Suppressive effects of glucagon-like_peptide-1 on interferon-gamma-induced nitric_oxide production in insulin-producing cells is mediated by inhibition of tumor_necrosis_factor-alpha production .
20410217	0	nitric_oxide	91,103	tumor_necrosis_factor-alpha	15,42	nitric oxide	tumor necrosis factor-alpha	MESH:D009569	21926(Tax:10090)	Chemical	Gene	inhibitor|amod|START_ENTITY Involvement|nmod|inhibitor Involvement|nmod|END_ENTITY	Involvement of tumor_necrosis_factor-alpha in natriuretic response to systemic infusion of nitric_oxide synthase inhibitor in anesthetized mice .
20633123	0	nitric_oxide	58,70	tumor_necrosis_factor-alpha	17,44	nitric oxide	tumor necrosis factor-alpha	MESH:D009569	24835(Tax:10116)	Chemical	Gene	antibodies|amod|START_ENTITY antibodies|amod|END_ENTITY	A combination of tumor_necrosis_factor-alpha and neuronal nitric_oxide synthase antibodies applied topically over the traumatized spinal cord enhances neuroprotection and functional recovery in the rat .
7538424	0	nitric_oxide	17,29	tumor_necrosis_factor-alpha	103,130	nitric oxide	tumor necrosis factor-alpha	MESH:D009569	7124	Chemical	Gene	role|nmod|START_ENTITY Lack|nmod|role Lack|nmod|destabilization destabilization|nmod|mRNA mRNA|nmod|END_ENTITY	Lack of role for nitric_oxide -LRB- NO -RRB- in the selective destabilization of endothelial NO synthase mRNA by tumor_necrosis_factor-alpha .
7693830	0	nitric_oxide	125,137	tumor_necrosis_factor-alpha	65,92	nitric oxide	tumor necrosis factor-alpha	MESH:D009569	21926(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY induction|nmod|production END_ENTITY|nmod|induction	Interferon-gamma , but not interferon-alpha_beta , synergizes with tumor_necrosis_factor-alpha and lipid_A in the induction of nitric_oxide production by murine L929 cells .
7883956	0	nitric_oxide	159,171	tumor_necrosis_factor-alpha	28,55	nitric oxide	tumor necrosis factor-alpha	MESH:D009569	7124	Chemical	Gene	role|nmod|START_ENTITY Effect|dep|role Effect|nmod|END_ENTITY	Effect of recombinant human tumor_necrosis_factor-alpha on cerebral oxygen uptake , cerebrospinal fluid lactate , and cerebral blood flow in the rabbit : role of nitric_oxide .
8125855	0	nitric_oxide	8,20	tumor_necrosis_factor-alpha	35,62	nitric oxide	tumor necrosis factor-alpha	MESH:D009569	24835(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|effects effects|nmod|END_ENTITY	Role of nitric_oxide in effects of tumor_necrosis_factor-alpha on microcirculation in rat .
8639904	0	nitric_oxide	95,107	tumor_necrosis_factor-alpha	119,146	nitric oxide	tumor necrosis factor-alpha	MESH:D009569	21926(Tax:10090)	Chemical	Gene	pathway|amod|START_ENTITY induction|nmod|pathway mediated|nmod|induction mediated|nmod|END_ENTITY	Suppression of B-cell proliferation to lipopolysaccharide is mediated through induction of the nitric_oxide pathway by tumor_necrosis_factor-alpha in mice with acute_graft-versus-host_disease .
9242548	0	nitric_oxide	22,34	tumor_necrosis_factor-alpha	45,72	nitric oxide	tumor necrosis factor-alpha	MESH:D009569	493755(Tax:9685)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|production production|amod|END_ENTITY	Endogenously produced nitric_oxide increases tumor_necrosis_factor-alpha production in transfected human U937 cells .
9648854	0	nitric_oxide	13,25	tumor_necrosis_factor-alpha	117,144	nitric oxide	tumor necrosis factor-alpha	MESH:D009569	24835(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY Induction|nmod|synthase Induction|nmod|END_ENTITY	Induction of nitric_oxide synthase and nitric_oxide-mediated apoptosis in neuronal PC12 cells after stimulation with tumor_necrosis_factor-alpha / lipopolysaccharide .
10452106	0	nitric_oxide	22,34	tumor_necrosis_factor_alpha	71,98	nitric oxide	tumor necrosis factor alpha	MESH:D009569	21926(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	Inhibitory effects of nitric_oxide and interleukin-10 on production of tumor_necrosis_factor_alpha , interleukin-1_beta , and interleukin-6 in mouse alveolar macrophages .
10559188	0	nitric_oxide	78,90	tumor_necrosis_factor_alpha	26,53	nitric oxide	tumor necrosis factor alpha	MESH:D009569	7124	Chemical	Gene	element|amod|START_ENTITY functions|nmod|element functions|amod|END_ENTITY	A Sp1 binding site of the tumor_necrosis_factor_alpha promoter functions as a nitric_oxide response element .
11035727	0	nitric_oxide	16,28	tumor_necrosis_factor_alpha	124,151	nitric oxide	tumor necrosis factor alpha	MESH:D009569	21926(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY Augmentation|nmod|production vascular|nsubj|Augmentation vascular|nmod|END_ENTITY	Augmentation of nitric_oxide production by gamma interferon in a mouse vascular endothelial cell line and its modulation by tumor_necrosis_factor_alpha and lipopolysaccharide .
14715569	0	nitric_oxide	13,25	tumor_necrosis_factor_alpha	49,76	nitric oxide	tumor necrosis factor alpha	MESH:D009569	280943(Tax:9913)	Chemical	Gene	production|amod|START_ENTITY Induction|nmod|production mediated|nsubj|Induction mediated|nmod|END_ENTITY	Induction of nitric_oxide production mediated by tumor_necrosis_factor_alpha on staphylococcal enterotoxin C-stimulated bovine mammary gland cells .
14750034	0	nitric_oxide	133,145	tumor_necrosis_factor_alpha	90,117	nitric oxide	tumor necrosis factor alpha	MESH:D009569	7124	Chemical	Gene	level|compound|START_ENTITY level|amod|monocytes monocytes|nmod|cells cells|nmod|reduction reduction|nmod|END_ENTITY	Demethylbellidifolin inhibits adhesion of monocytes to endothelial cells via reduction of tumor_necrosis_factor_alpha and endogenous nitric_oxide synthase inhibitor level .
16144552	0	nitric_oxide	54,66	tumor_necrosis_factor_alpha	82,109	nitric oxide	tumor necrosis factor alpha	MESH:D009569	24835(Tax:10116)	Chemical	Gene	induction|nmod|START_ENTITY mediating|dobj|induction pathways|acl|mediating synthase|nsubj|pathways synthase|nmod|END_ENTITY	Signaling pathways mediating a selective induction of nitric_oxide synthase II by tumor_necrosis_factor_alpha in nerve growth factor-responsive cells .
16269668	0	nitric_oxide	12,24	tumor_necrosis_factor_alpha	48,75	nitric oxide	tumor necrosis factor alpha	MESH:D009569	7124	Chemical	Gene	synthase|compound|START_ENTITY synthase|acl|activation activation|nmod|END_ENTITY	Endothelial nitric_oxide synthase activation by tumor_necrosis_factor_alpha through neutral_sphingomyelinase_2 , _ sphingosine_kinase_1 , _ and_sphingosine_1_phosphate_receptors : a novel pathway relevant to the pathophysiology of endothelium .
17035338	0	nitric_oxide	112,124	tumor_necrosis_factor_alpha	15,42	nitric oxide	tumor necrosis factor alpha	MESH:D009569	21926(Tax:10090)	Chemical	Gene	IFN-gamma|nmod|START_ENTITY induction|nmod|IFN-gamma factor-kappaB|nmod|induction factor-kappaB|compound|END_ENTITY	Requirement of tumor_necrosis_factor_alpha and nuclear factor-kappaB in the induction by IFN-gamma of inducible nitric_oxide synthase in macrophages .
18703234	0	nitric_oxide	96,108	tumor_necrosis_factor_alpha	23,50	nitric oxide	tumor necrosis factor alpha	MESH:D009569	21926(Tax:10090)	Chemical	Gene	generation|compound|START_ENTITY roles|nmod|generation roles|nmod|END_ENTITY	Complementary roles of tumor_necrosis_factor_alpha and interferon_gamma in inducible microglial nitric_oxide generation .
19063961	0	nitric_oxide	8,20	tumor_necrosis_factor_alpha	77,104	nitric oxide	tumor necrosis factor alpha	MESH:D009569	21926(Tax:10090)	Chemical	Gene	factor-kappaB|amod|START_ENTITY Role|nmod|factor-kappaB Role|nmod|hepatotoxicity hepatotoxicity|compound|END_ENTITY	Role of nitric_oxide and nuclear factor-kappaB in the CYP2E1 potentiation of tumor_necrosis_factor_alpha hepatotoxicity in mice .
22636782	0	nitric_oxide	20,32	tumor_necrosis_factor_alpha	46,73	nitric oxide	tumor necrosis factor alpha	MESH:D009569	7124	Chemical	Gene	hijacks|nsubj|START_ENTITY hijacks|dobj|END_ENTITY	Bacterium-generated nitric_oxide hijacks host tumor_necrosis_factor_alpha signaling and modulates the host cell cycle in vitro .
7691748	0	nitric_oxide	12,24	tumor_necrosis_factor_alpha	172,199	nitric oxide	tumor necrosis factor alpha	MESH:D009569	21926(Tax:10090)	Chemical	Gene	pathway|amod|START_ENTITY Role|nmod|pathway Role|acl|treated treated|nmod|interferon interferon|compound|END_ENTITY	Role of the nitric_oxide synthase pathway in inhibition of growth of interferon-sensitive and interferon-resistant Rickettsia_prowazekii strains in L929 cells treated with tumor_necrosis_factor_alpha and gamma interferon .
7743368	0	nitric_oxide	32,44	tumor_necrosis_factor_alpha	81,108	nitric oxide	tumor necrosis factor alpha	MESH:D009569	7124	Chemical	Gene	synthesis|amod|START_ENTITY products|nmod|synthesis levels|nmod|products correlate|nsubj|levels correlate|nmod|END_ENTITY	Serum levels of end products of nitric_oxide synthesis correlate positively with tumor_necrosis_factor_alpha and negatively with body temperature in patients with postoperative abdominal_sepsis .
8557372	0	nitric_oxide	22,34	tumor_necrosis_factor_alpha	49,76	nitric oxide	tumor necrosis factor alpha	MESH:D009569	21926(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY production|nmod|interferon interferon|compound|END_ENTITY	In vivo regulation of nitric_oxide production by tumor_necrosis_factor_alpha and gamma interferon , but not by interleukin-4 , during blood stage malaria in mice .
8597057	0	nitric_oxide	96,108	tumor_necrosis_factor_alpha	18,45	nitric oxide	tumor necrosis factor alpha	MESH:D009569	21926(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY Tolerance|dep|role Tolerance|nmod|END_ENTITY	Tolerance against tumor_necrosis_factor_alpha -LRB- TNF -RRB- - induced hepatotoxicity in mice : the role of nitric_oxide .
8903396	0	nitric_oxide	10,22	tumor_necrosis_factor_alpha	111,138	nitric oxide	tumor necrosis factor alpha	MESH:D009569	24835(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY activity|dep|roles roles|nmod|END_ENTITY	Increased nitric_oxide synthase activity as a cause of mitochondrial_dysfunction in rat hepatocytes : roles for tumor_necrosis_factor_alpha .
9419012	0	nitric_oxide	28,40	tumor_necrosis_factor_alpha	80,107	nitric oxide	tumor necrosis factor alpha	MESH:D009569	7124	Chemical	Gene	synthase-2|amod|START_ENTITY induce|dobj|synthase-2 induce|nmod|endothelium endothelium|nmod|END_ENTITY	Activated astrocytes induce nitric_oxide synthase-2 in cerebral endothelium via tumor_necrosis_factor_alpha .
9723947	0	nitric_oxide	175,187	tumor_necrosis_factor_alpha	34,61	nitric oxide	tumor necrosis factor alpha	MESH:D009569	21926(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY stimulating|dobj|production inhibits|advcl|stimulating inhibits|nsubj|administration administration|nmod|END_ENTITY	The intravenous administration of tumor_necrosis_factor_alpha , interleukin 8 and macrophage-derived neutrophil chemotactic factor inhibits neutrophil migration by stimulating nitric_oxide production .
11136730	0	nitric_oxide	15,27	tyrosinase	81,91	nitric oxide	tyrosinase	MESH:D009569	7299	Chemical	Gene	effects|nmod|START_ENTITY mediated|nsubj|effects mediated|nmod|END_ENTITY	The effects of nitric_oxide on the oxidations of l-dopa and dopamine mediated by tyrosinase and peroxidase .
8576448	0	nitric_oxide	19,31	tyrosine_hydroxylase	43,63	nitric oxide	tyrosine hydroxylase	MESH:D009569	100734150	Chemical	Gene	synthase|amod|START_ENTITY synthase|dep|END_ENTITY	Interdigitation of nitric_oxide synthase - , tyrosine_hydroxylase - , and serotonin-containing neurons in and around the laterodorsal and pedunculopontine tegmental nuclei of the guinea_pig .
11441907	0	nitric_oxide	100,112	urotensin_II	6,18	nitric oxide	urotensin II	MESH:D009569	29180(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY potentiation|nmod|synthase heart|dep|potentiation pressure|nmod|heart increases|dobj|pressure increases|nsubj|END_ENTITY	Human urotensin_II increases coronary perfusion pressure in the isolated rat heart : potentiation by nitric_oxide synthase and cyclooxygenase inhibition .
12074941	0	nitric_oxide	19,31	urotensin_II	112,124	nitric oxide	urotensin II	MESH:D009569	10911	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|dep|systems systems|nmod|action action|nmod|END_ENTITY	Involvement of the nitric_oxide / L-arginine and sympathetic nervous systems on the vasodepressor action of human urotensin_II in anesthetized rats .
12195278	0	nitric_oxide	31,43	urotensin_II	11,23	nitric oxide	urotensin II	MESH:D009569	29180(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	-LSB- Effect of urotensin_II on the nitric_oxide production in neonatal rat cardiomyocytes -RSB- .
16159683	0	nitric_oxide	119,131	urotensin_II	31,43	nitric oxide	urotensin II	MESH:D009569	29180(Tax:10116)	Chemical	Gene	aging|nmod|START_ENTITY influence|nmod|aging rats|dep|influence END_ENTITY|nmod|rats	Vascular contractile effect of urotensin_II in young and aged rats : influence of aging and contribution of endothelial nitric_oxide .
9388244	0	nitric_oxide	74,86	vascular_cell_adhesion_molecule-1	26,59	nitric oxide	vascular cell adhesion molecule-1	MESH:D009569	22329(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Inhibition of endothelial vascular_cell_adhesion_molecule-1 expression by nitric_oxide involves the induction and nuclear translocation of IkappaBalpha .
10024512	0	nitric_oxide	119,131	vascular_endothelial_growth_factor	27,61	nitric oxide	vascular endothelial growth factor	MESH:D009569	83785(Tax:10116)	Chemical	Gene	cells|amod|START_ENTITY mediated|nmod|cells mediated|nsubjpass|regulation regulation|nmod|END_ENTITY	Differential regulation of vascular_endothelial_growth_factor and its receptor fms-like-tyrosine kinase is mediated by nitric_oxide in rat renal mesangial cells .
10235536	0	nitric_oxide	88,100	vascular_endothelial_growth_factor	34,68	nitric oxide	vascular endothelial growth factor	MESH:D009569	7422	Chemical	Gene	Suppression|nmod|START_ENTITY Suppression|nmod|expression expression|compound|END_ENTITY	Suppression of hypoxia-associated vascular_endothelial_growth_factor gene expression by nitric_oxide via cGMP .
10408410	0	nitric_oxide	97,109	vascular_endothelial_growth_factor	24,58	nitric oxide	vascular endothelial growth factor	MESH:D009569	7422	Chemical	Gene	START_ENTITY|nsubj|concentrations concentrations|nmod|END_ENTITY	Serum concentrations of vascular_endothelial_growth_factor and nitrite as an estimate of in vivo nitric_oxide in patients with gastric_cancer .
10600037	0	nitric_oxide	68,80	vascular_endothelial_growth_factor	17,51	nitric oxide	vascular endothelial growth factor	MESH:D009569	7422	Chemical	Gene	synthase|compound|START_ENTITY synthase|compound|END_ENTITY	Gene transfer of vascular_endothelial_growth_factor and endothelial nitric_oxide synthase -- implications for gene therapy in cardiovascular_diseases .
10607702	0	nitric_oxide	117,129	vascular_endothelial_growth_factor	38,72	nitric oxide	vascular endothelial growth factor	MESH:D009569	7422	Chemical	Gene	mediates|nmod|START_ENTITY mediates|nsubj|element element|nmod|gene gene|compound|END_ENTITY	Hypoxia response element of the human vascular_endothelial_growth_factor gene mediates transcriptional regulation by nitric_oxide : control of hypoxia-inducible_factor-1 activity by nitric_oxide .
10607702	0	nitric_oxide	181,193	vascular_endothelial_growth_factor	38,72	nitric oxide	vascular endothelial growth factor	MESH:D009569	7422	Chemical	Gene	activity|nmod|START_ENTITY control|nmod|activity mediates|parataxis|control mediates|nsubj|element element|nmod|gene gene|compound|END_ENTITY	Hypoxia response element of the human vascular_endothelial_growth_factor gene mediates transcriptional regulation by nitric_oxide : control of hypoxia-inducible_factor-1 activity by nitric_oxide .
10629427	0	nitric_oxide	16,28	vascular_endothelial_growth_factor	138,172	nitric oxide	vascular endothelial growth factor	MESH:D009569	281572(Tax:9913)	Chemical	Gene	Significance|nmod|START_ENTITY Significance|acl|induced induced|nmod|END_ENTITY	Significance of nitric_oxide and peroxynitrite in permeability changes of the retinal microvascular endothelial cell monolayer induced by vascular_endothelial_growth_factor .
11352660	0	nitric_oxide	25,37	vascular_endothelial_growth_factor	41,75	nitric oxide	vascular endothelial growth factor	MESH:D009569	7422	Chemical	Gene	START_ENTITY|nmod|down-regulates down-regulates|compound|END_ENTITY	Endogenous production of nitric_oxide by vascular_endothelial_growth_factor down-regulates proliferation of choriocarcinoma cells .
11479503	0	nitric_oxide	49,61	vascular_endothelial_growth_factor	77,111	nitric oxide	vascular endothelial growth factor	MESH:D009569	7422	Chemical	Gene	releases|xcomp|START_ENTITY releases|xcomp|END_ENTITY	The human internal thoracic artery releases more nitric_oxide in response to vascular_endothelial_growth_factor than the human saphenous vein .
11506896	0	nitric_oxide	51,63	vascular_endothelial_growth_factor	13,47	nitric oxide	vascular endothelial growth factor	MESH:D009569	7422	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of vascular_endothelial_growth_factor by nitric_oxide in cultured human articular chondrocytes .
12010247	0	nitric_oxide	72,84	vascular_endothelial_growth_factor	29,63	nitric oxide	vascular endothelial growth factor	MESH:D009569	83785(Tax:10116)	Chemical	Gene	isoforms|amod|START_ENTITY induces|dobj|isoforms induces|nsubj|injection injection|nmod|END_ENTITY	Intracavernosal injection of vascular_endothelial_growth_factor induces nitric_oxide synthase isoforms .
12200144	0	nitric_oxide	11,23	vascular_endothelial_growth_factor	34,68	nitric oxide	vascular endothelial growth factor	MESH:D009569	7422	Chemical	Gene	donors|amod|START_ENTITY Effects|nmod|donors Effects|nmod|induction induction|compound|END_ENTITY	Effects of nitric_oxide donors on vascular_endothelial_growth_factor gene induction .
12218334	0	nitric_oxide	147,159	vascular_endothelial_growth_factor	25,59	nitric oxide	vascular endothelial growth factor	MESH:D009569	83785(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY inhibition|nmod|synthesis synthase|nmod|inhibition synthase|nsubj|expression expression|nmod|END_ENTITY	Reciprocal expression of vascular_endothelial_growth_factor and nitric_oxide synthase by coronary arterial wall cells during chronic inhibition of nitric_oxide synthesis in rats .
12626124	0	nitric_oxide	62,74	vascular_endothelial_growth_factor	14,48	nitric oxide	vascular endothelial growth factor	MESH:D009569	7422	Chemical	Gene	synthesis|nmod|START_ENTITY synthesis|compound|END_ENTITY	Regulation of vascular_endothelial_growth_factor synthesis by nitric_oxide : facts and controversies .
12673348	0	nitric_oxide	44,56	vascular_endothelial_growth_factor	75,109	nitric oxide	vascular endothelial growth factor	MESH:D009569	22339(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of protoporphyrins on production of nitric_oxide and expression of vascular_endothelial_growth_factor in vascular smooth muscle cells and macrophages .
12773701	0	nitric_oxide	90,102	vascular_endothelial_growth_factor	14,48	nitric oxide	vascular endothelial growth factor	MESH:D009569	22339(Tax:10090)	Chemical	Gene	macrophages|nmod|START_ENTITY macrophages|nsubj|Regulation Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of vascular_endothelial_growth_factor gene expression in murine macrophages by nitric_oxide and hypoxia .
12773981	0	nitric_oxide	24,36	vascular_endothelial_growth_factor	77,111	nitric oxide	vascular endothelial growth factor	MESH:D009569	397157(Tax:9823)	Chemical	Gene	START_ENTITY|nmod|reductions reductions|nmod|expression expression|compound|END_ENTITY	Inhibition of inducible nitric_oxide synthase results in reductions in wound vascular_endothelial_growth_factor expression , granulation tissue formation , and local perfusion .
12943528	0	nitric_oxide	29,41	vascular_endothelial_growth_factor	69,103	nitric oxide	vascular endothelial growth factor	MESH:D009569	83785(Tax:10116)	Chemical	Gene	inhibits|iobj|START_ENTITY inhibits|parataxis|END_ENTITY	Aspirin inhibits endothelial nitric_oxide synthase -LRB- eNOS -RRB- and Flk-1 -LRB- vascular_endothelial_growth_factor receptor-2 -RRB- prior to rat colon_tumour development .
14568906	0	nitric_oxide	36,48	vascular_endothelial_growth_factor	71,105	nitric oxide	vascular endothelial growth factor	MESH:D009569	83785(Tax:10116)	Chemical	Gene	gene|compound|START_ENTITY induced|nmod|gene induced|nmod|expression expression|compound|END_ENTITY	Angiogenesis induced by endothelial nitric_oxide synthase gene through vascular_endothelial_growth_factor expression in a rat hindlimb ischemia model .
15176455	0	nitric_oxide	15,27	vascular_endothelial_growth_factor	56,90	nitric oxide	vascular endothelial growth factor	MESH:D009569	7422	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|isoforms isoforms|compound|END_ENTITY	Involvement of nitric_oxide in angiogenic activities of vascular_endothelial_growth_factor isoforms .
15339980	0	nitric_oxide	10,22	vascular_endothelial_growth_factor	106,140	nitric oxide	vascular endothelial growth factor	MESH:D009569	83785(Tax:10116)	Chemical	Gene	nitric_oxide|amod|START_ENTITY promotes|nsubj|nitric_oxide promotes|dobj|angiogenesis angiogenesis|nmod|upregulation upregulation|nmod|receptors receptors|compound|END_ENTITY	Inducible nitric_oxide synthase-derived nitric_oxide promotes glomerular angiogenesis via upregulation of vascular_endothelial_growth_factor receptors .
15339980	0	nitric_oxide	40,52	vascular_endothelial_growth_factor	106,140	nitric oxide	vascular endothelial growth factor	MESH:D009569	83785(Tax:10116)	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|angiogenesis angiogenesis|nmod|upregulation upregulation|nmod|receptors receptors|compound|END_ENTITY	Inducible nitric_oxide synthase-derived nitric_oxide promotes glomerular angiogenesis via upregulation of vascular_endothelial_growth_factor receptors .
15473891	0	nitric_oxide	99,111	vascular_endothelial_growth_factor	18,52	nitric oxide	vascular endothelial growth factor	MESH:D009569	83785(Tax:10116)	Chemical	Gene	influence|nmod|START_ENTITY cells|dep|influence activates|nmod|cells activates|dobj|END_ENTITY	Insulin activates vascular_endothelial_growth_factor in vascular smooth muscle cells : influence of nitric_oxide and of insulin resistance .
16020977	0	nitric_oxide	24,36	vascular_endothelial_growth_factor	93,127	nitric oxide	vascular endothelial growth factor	MESH:D009569	7422	Chemical	Gene	synthase|compound|START_ENTITY Expression|nmod|synthase correlated|nsubj|Expression correlated|nmod|expression expression|nmod|infiltration infiltration|compound|END_ENTITY	Expression of inducible nitric_oxide synthase is significantly correlated with expression of vascular_endothelial_growth_factor and dendritic cell infiltration in patients with advanced gastric_carcinoma .
16436494	0	nitric_oxide	54,66	vascular_endothelial_growth_factor	14,48	nitric oxide	vascular endothelial growth factor	MESH:D009569	281572(Tax:9913)	Chemical	Gene	Uncoupling|nmod|START_ENTITY Uncoupling|nmod|END_ENTITY	Uncoupling of vascular_endothelial_growth_factor with nitric_oxide as a mechanism for diabetic_vasculopathy .
16631200	0	nitric_oxide	58,70	vascular_endothelial_growth_factor	100,134	nitric oxide	vascular endothelial growth factor	MESH:D009569	397157(Tax:9823)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Local arginine supplementation results in sustained wound nitric_oxide production and reductions in vascular_endothelial_growth_factor expression and granulation tissue formation .
17462148	0	nitric_oxide	103,115	vascular_endothelial_growth_factor	28,62	nitric oxide	vascular endothelial growth factor	MESH:D009569	7422	Chemical	Gene	-RSB-|amod|START_ENTITY Study|nmod|-RSB- Study|nmod|inhibition inhibition|nmod|expression expression|compound|END_ENTITY	-LSB- Study on the inhibition of vascular_endothelial_growth_factor expression in Tca8113 cell by inducible nitric_oxide synthase gene RNA interference -RSB- .
17704550	0	nitric_oxide	87,99	vascular_endothelial_growth_factor	18,52	nitric oxide	vascular endothelial growth factor	MESH:D009569	7422	Chemical	Gene	urokinase-type_plasminogen_activator|amod|START_ENTITY END_ENTITY|nmod|urokinase-type_plasminogen_activator	Relation of serum vascular_endothelial_growth_factor as an angiogenesis biomarker with nitric_oxide _ urokinase-type_plasminogen_activator in breast_cancer patients .
17827251	0	nitric_oxide	14,26	vascular_endothelial_growth_factor	106,140	nitric oxide	vascular endothelial growth factor	MESH:D009569	83785(Tax:10116)	Chemical	Gene	decreases|amod|START_ENTITY apoptosis|nsubj|decreases apoptosis|nmod|inhibition inhibition|compound|END_ENTITY	Early inhaled nitric_oxide treatment decreases apoptosis of endothelial cells in neonatal rat lungs after vascular_endothelial_growth_factor inhibition .
17988548	0	nitric_oxide	92,104	vascular_endothelial_growth_factor	45,79	nitric oxide	vascular endothelial growth factor	MESH:D009569	7422	Chemical	Gene	synthase|compound|START_ENTITY synthase|compound|END_ENTITY	-LSB- Expressions of and the effect of smoking on vascular_endothelial_growth_factor and induced nitric_oxide synthase in lung tissues of chronic_obstructive_pulmonary_disease patients -RSB- .
19285541	0	nitric_oxide	110,122	vascular_endothelial_growth_factor	61,95	nitric oxide	vascular endothelial growth factor	MESH:D009569	83785(Tax:10116)	Chemical	Gene	synthases|dep|START_ENTITY synthases|compound|END_ENTITY	Combustion smoke exposure induces up-regulated expression of vascular_endothelial_growth_factor , aquaporin_4 , nitric_oxide synthases and vascular permeability in the retina of adult rats .
20429654	0	nitric_oxide	82,94	vascular_endothelial_growth_factor	46,80	nitric oxide	vascular endothelial growth factor	MESH:D009569	7422	Chemical	Gene	synthase|amod|START_ENTITY synthase|dep|END_ENTITY	Inflammatory infiltrate , microvessel density , vascular_endothelial_growth_factor , nitric_oxide synthase , and proliferative activity in soft tissues below intraorally welded titanium bars .
20435094	0	nitric_oxide	102,114	vascular_endothelial_growth_factor	59,93	nitric oxide	vascular endothelial growth factor	MESH:D009569	7422	Chemical	Gene	synthase|amod|START_ENTITY activity|amod|synthase induced|dobj|activity induced|nsubj|study study|nmod|transduction transduction|nmod|END_ENTITY	Electrochemical study of the intracellular transduction of vascular_endothelial_growth_factor induced nitric_oxide synthase activity using a multi-channel biocompatible microelectrode array .
20698860	0	nitric_oxide	114,126	vascular_endothelial_growth_factor	63,97	nitric oxide	vascular endothelial growth factor	MESH:D009569	83785(Tax:10116)	Chemical	Gene	synthase|compound|START_ENTITY synthase|amod|END_ENTITY	Homocysteine impaired endothelial function through compromised vascular_endothelial_growth_factor / Akt/endothelial nitric_oxide synthase signalling .
22529296	0	nitric_oxide	26,38	vascular_endothelial_growth_factor	136,170	nitric oxide	vascular endothelial growth factor	MESH:D009569	22339(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY controls|nsubj|synthase controls|nmod|modulation modulation|nmod|release release|compound|END_ENTITY	Tumor-expressed inducible nitric_oxide synthase controls induction of functional myeloid-derived suppressor cells through modulation of vascular_endothelial_growth_factor release .
23283573	0	nitric_oxide	114,126	vascular_endothelial_growth_factor	36,70	nitric oxide	vascular endothelial growth factor	MESH:D009569	22339(Tax:10090)	Chemical	Gene	pathway|amod|START_ENTITY modulate|nmod|pathway modulate|dobj|release release|compound|END_ENTITY	Beta3-adrenergic receptors modulate vascular_endothelial_growth_factor release in response to hypoxia through the nitric_oxide pathway in mouse retinal explants .
23458507	0	nitric_oxide	76,88	vascular_endothelial_growth_factor	20,54	nitric oxide	vascular endothelial growth factor	MESH:D009569	7422	Chemical	Gene	endothelin-1|amod|START_ENTITY focus|nmod|endothelin-1 Hypertension|dep|focus Hypertension|nmod|inhibition inhibition|compound|END_ENTITY	Hypertension during vascular_endothelial_growth_factor inhibition : focus on nitric_oxide , endothelin-1 , and oxidative stress .
9242380	0	nitric_oxide	51,63	vascular_endothelial_growth_factor	13,47	nitric oxide	vascular endothelial growth factor	MESH:D009569	7422	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of vascular_endothelial_growth_factor by nitric_oxide in human glioblastoma and hepatocellular_carcinoma cells .
9571172	0	nitric_oxide	48,60	vascular_endothelial_growth_factor	10,44	nitric oxide	vascular endothelial growth factor	MESH:D009569	83785(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY Effect|nmod|production Effect|nmod|END_ENTITY	Effect of vascular_endothelial_growth_factor on nitric_oxide production by cultured rat mesangial cells .
9510014	0	nitric_oxide	21,33	vasoactive_intestinal_polypeptide	63,96	nitric oxide	vasoactive intestinal polypeptide	MESH:D009569	7432	Chemical	Gene	role|nmod|START_ENTITY induced|nsubj|role induced|nmod|END_ENTITY	Predominant role for nitric_oxide in the relaxation induced by vasoactive_intestinal_polypeptide in human uterine artery .
17996497	0	nitric_oxide	10,22	vasopressin	69,80	nitric oxide	vasopressin	MESH:D009569	551	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of nitric_oxide on responses of the human uterine arteries to vasopressin .
24965902	0	nitric_oxide	136,148	vasopressin	10,21	nitric oxide	vasopressin	MESH:D009569	551	Chemical	Gene	system|amod|START_ENTITY inhibition|nmod|system antagonism|nmod|inhibition antagonism|nsubj|Effect Effect|nmod|END_ENTITY	Effect of vasopressin antagonism on renal handling of sodium and water and central and brachial blood pressure during inhibition of the nitric_oxide system in healthy subjects .
7628398	0	nitric_oxide	12,24	vasopressin	116,127	nitric oxide	vasopressin	MESH:D009569	551	Chemical	Gene	adrenocorticotropin|amod|START_ENTITY Blockade|nmod|adrenocorticotropin Blockade|dep|role role|nmod|receptors receptors|amod|1-adrenergic 1-adrenergic|dep|END_ENTITY	Blockade of nitric_oxide formation augments adrenocorticotropin released by blood-borne interleukin-1_beta : role of vasopressin , prostaglandins , and alpha 1-adrenergic receptors .
19049863	0	nitric_oxide	131,143	xanthine_oxidase	98,114	nitric oxide	xanthine oxidase	MESH:D009569	22436(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY synthase|amod|END_ENTITY	Immuno-spin trapping of a post-translational carboxypeptidase B1 radical formed by a dual role of xanthine_oxidase and endothelial nitric_oxide synthase in acute septic mice .
17034136	0	nitrile	41,48	cathepsin_s	63,74	nitrile	cathepsin s	CHEBI:18379	1520	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|nmod|END_ENTITY	Identification of selective , nonpeptidic nitrile inhibitors of cathepsin_s using the substrate activity screening method .
2379734	0	nitriles	55,63	cathepsin_B	21,32	nitriles	cathepsin B	MESH:D009570	281105(Tax:9913)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of bovine cathepsin_B by amino_acid-derived nitriles .
12920627	0	nitrite	25,32	Adrenomedullin	0,14	nitrite	Adrenomedullin	CHEBI:16301	133	Chemical	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Adrenomedullin and total nitrite levels in children with Henoch-Sch nlein purpura .
15885231	0	nitrite	25,32	Adrenomedullin	0,14	nitrite	Adrenomedullin	CHEBI:16301	133	Chemical	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Adrenomedullin and total nitrite levels in children with acute_rheumatic_fever .
16712551	0	nitrite	25,32	Adrenomedullin	0,14	nitrite	Adrenomedullin	CHEBI:16301	133	Chemical	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Adrenomedullin and total nitrite levels in children with familial_Mediterranean_fever .
18250410	0	nitrite	141,148	Akt	99,102	nitrite	Akt	CHEBI:16301	11651(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY activation|nmod|production activation|compound|END_ENTITY	Critical roles of the p110_beta subtype of phosphoinositide 3-kinase in lipopolysaccharide-induced Akt activation and negative regulation of nitrite production in RAW 264.7 cells .
24164360	0	nitrite	63,70	Aldehyde_dehydrogenase_2	0,24	nitrite	Aldehyde dehydrogenase 2	CHEBI:16301	24188(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY mediates|dobj|effect mediates|nsubj|END_ENTITY	Aldehyde_dehydrogenase_2 partly mediates hypotensive effect of nitrite on L-NAME-induced hypertension in normoxic rat .
11104730	0	nitrite	73,80	IFN-gamma	46,55	nitrite	IFN-gamma	CHEBI:16301	25712(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY production|amod|END_ENTITY	Surfactant protein A differentially regulates IFN-gamma - and LPS-induced nitrite production by rat alveolar macrophages .
1731791	6	nitrite	952,959	IL-1_beta	924,933	nitrite	IL-1 beta	CHEBI:16301	24494(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	The islets responded to IL-1_beta with an increased nitrite production and a decreased activity of aconitase , whereas the islet glucose oxidation rates were not decreased .
15135362	0	nitrite	31,38	Interleukin-1beta	0,17	nitrite	Interleukin-1beta	CHEBI:16301	24494(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY production|amod|END_ENTITY	Interleukin-1beta up-regulates nitrite production : effects on ovarian function .
9705211	0	nitrite	88,95	Myeloperoxidase	0,15	nitrite	Myeloperoxidase	CHEBI:16301	303413(Tax:10116)	Chemical	Gene	catalyze|nmod|START_ENTITY catalyze|nsubj|peroxidase peroxidase|amod|END_ENTITY	Myeloperoxidase and horseradish peroxidase catalyze tyrosine nitration in proteins from nitrite and hydrogen_peroxide .
26259199	0	nitrite	14,21	NIR1	35,39	nitrite	NIR1	CHEBI:16301	816055(Tax:3702)	Chemical	Gene	reductase|amod|START_ENTITY reductase|appos|END_ENTITY	HY5 regulates nitrite reductase 1 -LRB- NIR1 -RRB- and ammonium_transporter1 ; 2 -LRB- AMT1 ; 2 -RRB- in Arabidopsis seedlings .
7603437	0	nitrite	50,57	Nir1	4,8	nitrite	Nir1	CHEBI:16301	548306(Tax:4513)	Chemical	Gene	Nii|amod|START_ENTITY linked|nmod|Nii linked|nsubjpass|locus locus|amod|END_ENTITY	The Nir1 locus in barley is tightly linked to the nitrite reductase apoprotein gene Nii .
22182649	0	nitrite	6,13	Sri	24,27	nitrite	Sri	CHEBI:16301	6717	Chemical	Gene	START_ENTITY|nmod|patients patients|compound|END_ENTITY	Serum nitrite levels in Sri Lankan patients with leptospirosis .
1713193	0	nitrite	20,27	catalase	72,80	nitrite	catalase	CHEBI:16301	12359(Tax:10090)	Chemical	Gene	produce|dobj|START_ENTITY produce|nmod|addition addition|nmod|END_ENTITY	Macrophages produce nitrite , nitrate and nitrosamines after addition of catalase .
3220326	0	nitrite	15,22	catalase	28,36	nitrite	catalase	CHEBI:16301	24248(Tax:10116)	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of nitrite with catalase in the perfused rat liver .
3754494	0	nitrite	10,17	cytochrome_P-450	106,122	nitrite	cytochrome P-450	CHEBI:16301	4051	Chemical	Gene	formation|compound|START_ENTITY pathways|nsubj|formation pathways|advcl|END_ENTITY	Metabolic nitrite formation from N-nitrosamines : are there other pathways than reductive denitrosation by cytochrome_P-450 ?
676343	0	nitrite	10,17	cytochrome_P-450	32,48	nitrite	cytochrome P-450	CHEBI:16301	25251(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of nitrite on microsomal cytochrome_P-450 .
6805975	0	nitrite	10,17	cytochrome_P-450	64,80	nitrite	cytochrome P-450	CHEBI:16301	397687(Tax:9823)	Chemical	Gene	formation|compound|START_ENTITY formation|dep|evidence evidence|nmod|reaction reaction|amod|dependent dependent|amod|END_ENTITY	Metabolic nitrite formation from N-nitrosamines : evidence for a cytochrome_P-450 dependent reaction .
216667	0	nitrite	30,37	cytochrome_c	12,24	nitrite	cytochrome c	CHEBI:16301	104968582	Chemical	Gene	Reaction|nmod|START_ENTITY Reaction|nmod|END_ENTITY	Reaction of cytochrome_c with nitrite and nitric_oxide .
12873449	0	nitrite	13,20	endothelin-1	35,47	nitrite	endothelin-1	CHEBI:16301	1906	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Reduction of nitrite production by endothelin-1 in isolated porcine ciliary processes .
16336215	0	nitrite	13,20	eosinophil_peroxidase	34,55	nitrite	eosinophil peroxidase	CHEBI:16301	8288	Chemical	Gene	oxidation|amod|START_ENTITY oxidation|nmod|END_ENTITY	Mechanism of nitrite oxidation by eosinophil_peroxidase : implications for oxidant production and nitration by eosinophils .
18483281	0	nitrite	51,58	estrogen_receptor-alpha	14,37	nitrite	estrogen receptor-alpha	CHEBI:16301	2099	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of estrogen_receptor-alpha by the anion nitrite .
2040662	0	nitrite	45,52	interleukin-6	28,41	nitrite	interleukin-6	CHEBI:16301	3569	Chemical	Gene	production|amod|START_ENTITY Effect|nmod|production Effect|nmod|END_ENTITY	Effect of recombinant human interleukin-6 on nitrite production of mouse_myeloid_leukemia cells .
560873	0	nitrite	10,17	leghemoglobin	23,36	nitrite	leghemoglobin	CHEBI:16301	100527427	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of nitrite upon leghemoglobin and interaction with nitrogen fixation .
10777476	0	nitrite	46,53	myeloperoxidase	25,40	nitrite	myeloperoxidase	CHEBI:16301	4353	Chemical	Gene	Mechanism|nmod|START_ENTITY Mechanism|nmod|END_ENTITY	Mechanism of reaction of myeloperoxidase with nitrite .
1333417	0	nitrite	42,49	myeloperoxidase	21,36	nitrite	myeloperoxidase	CHEBI:16301	4353	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of human myeloperoxidase with nitrite .
15493876	0	nitrite	108,115	myeloperoxidase	73,88	nitrite	myeloperoxidase	CHEBI:16301	4353	Chemical	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	Oxidative modification of low-density lipoprotein : lipid peroxidation by myeloperoxidase in the presence of nitrite .
18280259	0	nitrite	86,93	myeloperoxidase	45,60	nitrite	myeloperoxidase	CHEBI:16301	4353	Chemical	Gene	depends|nmod|START_ENTITY depends|nsubj|Nitration Nitration|nmod|cells cells|nmod|END_ENTITY	Nitration of respiratory epithelial cells by myeloperoxidase depends on extracellular nitrite .
15080699	0	nitrite	31,38	myoglobin	201,210	nitrite	myoglobin	CHEBI:16301	4151	Chemical	Gene	reductions|acl|START_ENTITY cytochrome|nsubj|reductions cytochrome|nmod|END_ENTITY	Electrocatalytic reductions of nitrite , nitric_oxide , and nitrous_oxide by thermophilic cytochrome P450 CYP119 in film-modified electrodes and an analytical comparison of its catalytic activities with myoglobin .
16216040	0	nitrite	51,58	myoglobin	38,47	nitrite	myoglobin	CHEBI:16301	4151	Chemical	Gene	oxidation|nmod|START_ENTITY oxidation|nmod|END_ENTITY	Easy oxidation and nitration of human myoglobin by nitrite and hydrogen_peroxide .
19836457	0	nitrite	40,47	myoglobin	15,24	nitrite	myoglobin	CHEBI:16301	4151	Chemical	Gene	activity|amod|START_ENTITY highlight|dep|activity highlight|nmod|diversity diversity|compound|END_ENTITY	A highlight of myoglobin diversity : the nitrite reductase activity during myocardial_ischemia-reperfusion .
19924902	0	nitrite	91,98	myoglobin	51,60	nitrite	myoglobin	CHEBI:16301	100054434(Tax:9796)	Chemical	Gene	mode|nmod|START_ENTITY directs|dobj|mode directs|nsubj|residue residue|nmod|END_ENTITY	The distal pocket histidine residue in horse heart myoglobin directs the O-binding mode of nitrite to the heme_iron .
22280411	0	nitrite	58,65	myoglobin	17,26	nitrite	myoglobin	CHEBI:16301	4151	Chemical	Gene	cysteine|nmod|START_ENTITY curing|amod|cysteine Nitrosylation|nmod|curing Nitrosylation|nmod|END_ENTITY	Nitrosylation of myoglobin and nitrosation of cysteine by nitrite in a model system simulating meat curing .
22339632	0	nitrite	120,127	myoglobin	76,85	nitrite	myoglobin	CHEBI:16301	4151	Chemical	Gene	presence|nmod|START_ENTITY generated|nmod|presence generated|nmod|END_ENTITY	Oxidation of thiamine on reaction with nitrogen_dioxide generated by ferric myoglobin and hemoglobin in the presence of nitrite and hydrogen_peroxide .
26544504	0	nitrite	15,22	myoglobin	97,106	nitrite	myoglobin	CHEBI:16301	4151	Chemical	Gene	activity|amod|START_ENTITY Modulating|dobj|activity substituents|dep|Modulating substituents|parataxis|END_ENTITY	Modulating the nitrite reductase activity of globins by varying the heme substituents : Utilizing myoglobin as a model system .
8437574	0	nitrite	66,73	nir1	0,4	nitrite	nir1	CHEBI:16301	548306(Tax:4513)	Chemical	Gene	reduction|amod|START_ENTITY defect|nmod|reduction causing|dobj|defect barley|acl|causing mutation|nmod|barley END_ENTITY|appos|mutation	nir1 , a conditional-lethal mutation in barley causing a defect in nitrite reduction .
26374946	0	nitrite	66,73	xanthine_oxidoreductase	8,31	nitrite	xanthine oxidoreductase	CHEBI:16301	497811(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY Role|nmod|effects Role|nmod|END_ENTITY	Role of xanthine_oxidoreductase in the anti-thrombotic effects of nitrite in rats in vivo .
18040808	0	nitrites	20,28	VEGF	32,36	nitrites	VEGF	MESH:D009573	7422	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effects of inhalant nitrites on VEGF expression : a feasible link to Kaposi 's _ sarcoma ?
24632291	0	nitro-chloromethylbenzindolines	47,78	FOXRED2	17,24	nitro-chloromethylbenzindolines	FOXRED2	null	80020	Chemical	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	The flavoprotein FOXRED2 reductively activates nitro-chloromethylbenzindolines and other hypoxia-targeting prodrugs .
19857569	0	nitro-fatty_acids	106,123	endothelial_nitric_oxide_synthase	23,56	nitro-fatty acids	endothelial nitric oxide synthase	null	18127(Tax:10090)	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of vascular endothelial_nitric_oxide_synthase and heme_oxygenase-1 expression by electrophilic nitro-fatty_acids .
19534727	0	nitro-linoleic_acid	36,55	haem_oxygenase-1	6,22	nitro-linoleic acid	haem oxygenase-1	MESH:C501855	3162	Chemical	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Human haem_oxygenase-1 induction by nitro-linoleic_acid is mediated by cAMP , AP-1 and E-box response element interactions .
17909483	0	nitro-substituted_triaryl_pyrazole	19,53	estrogen_receptor	79,96	nitro-substituted triaryl pyrazole	estrogen receptor	null	2099	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Synthesis of novel nitro-substituted_triaryl_pyrazole derivatives as potential estrogen_receptor ligands .
8137280	0	nitroarenes	176,187	NAT1	60,64	nitroarenes	NAT1	CHEBI:51132	9	Chemical	Gene	expressing|nmod|START_ENTITY expressing|dobj|END_ENTITY	New sublines of Chinese_hamster CHL stably expressing human NAT1 or NAT2 N-acetyltransferases or Salmonella_typhimurium O-acetyltransferase : comparison of the sensitivities to nitroarenes and aromatic_amines using the in vitro micronucleus test .
16144976	0	nitroaspirin	58,70	cyclooxygenase-1	38,54	nitroaspirin	cyclooxygenase-1	MESH:C102148	5742	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Direct and irreversible inhibition of cyclooxygenase-1 by nitroaspirin -LRB- NCX_4016 -RRB- .
26847645	0	nitrobenzoxadiazoles	38,58	c-Jun_N-terminal_kinase	0,23	nitrobenzoxadiazoles	c-Jun N-terminal kinase	null	5599	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	c-Jun_N-terminal_kinase activation by nitrobenzoxadiazoles leads to late-stage autophagy inhibition .
11318939	0	nitrocatechol	56,69	COMT	70,74	nitrocatechol	COMT	MESH:C506350	24267(Tax:10116)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	D1-like dopamine receptor activation and natriuresis by nitrocatechol COMT inhibitors .
8512582	0	nitrocatechols	69,83	catechol-O-methyltransferase	14,42	nitrocatechols	catechol-O-methyltransferase	null	100155530(Tax:9823)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of catechol-O-methyltransferase by 1-vinyl derivatives of nitrocatechols and nitroguaiacols .
16292552	0	nitrofen	66,74	Connexin_43	14,25	nitrofen	Connexin 43	MESH:C007350	24392(Tax:10116)	Chemical	Gene	exposed|nmod|START_ENTITY exposed|nsubj|Expression Expression|nmod|END_ENTITY	Expression of Connexin_43 in the hearts of rat embryos exposed to nitrofen and effects of vitamin_A on it .
11240914	0	nitrogen	30,38	CO2	9,12	nitrogen	CO2	MESH:D009584	717	Chemical	Gene	acquisition|compound|START_ENTITY reduce|dobj|acquisition reduce|nsubj|END_ENTITY	Elevated CO2 and ozone reduce nitrogen acquisition by Pinus halepensis from its mycorrhizal symbiont .
11758430	0	nitrogen	80,88	CO2	35,38	nitrogen	CO2	MESH:D009584	717	Chemical	Gene	concentration|nmod|START_ENTITY concentration|compound|END_ENTITY	-LSB- Influence of elevated atmospheric CO2 concentration on photosynthesis and leaf nitrogen partition in process of photosynthetic carbon cycle in Musa paradisiaca -RSB- .
12060244	0	nitrogen	89,97	CO2	25,28	nitrogen	CO2	MESH:D009584	717	Chemical	Gene	augmented|nmod|START_ENTITY augmented|nsubj|Consequences Consequences|nmod|END_ENTITY	Consequences of elevated CO2 , augmented nitrogen-deposition and soil type on the soluble nitrogen and sulphur in the phloem of beech -LRB- Fagus sylvatica -RRB- and spruce -LRB- Picea abies -RRB- in a competitive situation .
12207663	0	nitrogen	33,41	CO2	20,23	nitrogen	CO2	MESH:D009584	717	Chemical	Gene	mobilization|compound|START_ENTITY inhibits|dobj|mobilization inhibits|nsubj|END_ENTITY	Reduced atmospheric CO2 inhibits nitrogen mobilization in Festuca rubra .
1318876	0	nitrogen	52,60	CO2	21,24	nitrogen	CO2	MESH:D009584	717	Chemical	Gene	gas|compound|START_ENTITY -LSB-|nmod|gas -LSB-|dobj|efficiencies efficiencies|compound|END_ENTITY	Optimization of -LSB- 11C -RSB- CO2 trapping efficiencies from nitrogen gas streams .
15322897	0	nitrogen	97,105	CO2	63,66	nitrogen	CO2	MESH:D009584	717	Chemical	Gene	productivities|compound|START_ENTITY END_ENTITY|nmod|productivities	A hierarchical analysis of the interactive effects of elevated CO2 and water availability on the nitrogen and transpiration productivities of velvet mesquite seedlings .
16634293	0	nitrogen	12,20	CO2	70,73	nitrogen	CO2	MESH:D009584	717	Chemical	Gene	limitation|compound|START_ENTITY processes|nsubj|limitation processes|nmod|END_ENTITY	Progressive nitrogen limitation of ecosystem processes under elevated CO2 in a warm-temperate forest .
16957400	0	nitrogen	94,102	CO2	40,43	nitrogen	CO2	MESH:D009584	717	Chemical	Gene	-RSB-|compound|START_ENTITY levels|nmod|-RSB- grown|nmod|levels leaves|acl|grown acclimation|nmod|leaves acclimation|nmod|END_ENTITY	-LSB- Photosynthetic acclimation to elevated CO2 in strawberry leaves grown at different levels of nitrogen nutrition -RSB- .
17396505	0	nitrogen	81,89	CO2	21,24	nitrogen	CO2	MESH:D009584	717	Chemical	Gene	-RSB-|compound|START_ENTITY leaves|nmod|-RSB- leaves|nsubj|Effects Effects|nmod|END_ENTITY	-LSB- Effects of elevated CO2 on photoinhibition of strawberry leaves under different nitrogen levels -RSB- .
17504464	0	nitrogen	8,16	CO2	64,67	nitrogen	CO2	MESH:D009584	717	Chemical	Gene	allocation|compound|START_ENTITY controls|nsubj|allocation controls|nmod|END_ENTITY	Optimal nitrogen allocation controls tree responses to elevated CO2 .
17709743	0	nitrogen	13,21	CO2	134,137	nitrogen	CO2	MESH:D009584	717	Chemical	Gene	uptake|compound|START_ENTITY Increases|nmod|uptake support|nsubj|Increases support|nmod|END_ENTITY	Increases in nitrogen uptake rather than nitrogen-use efficiency support higher rates of temperate forest productivity under elevated CO2 .
19017124	0	nitrogen	8,16	CO2	70,73	nitrogen	CO2	MESH:D009584	717	Chemical	Gene	concentrations|compound|START_ENTITY lower|nsubj|concentrations lower|nmod|END_ENTITY	Why are nitrogen concentrations in plant tissues lower under elevated CO2 ?
19489111	0	nitrogen	71,79	CO2	10,13	nitrogen	CO2	MESH:D009584	717	Chemical	Gene	levels|compound|START_ENTITY enrichment|nmod|levels enrichment|nsubj|Effect Effect|nmod|END_ENTITY	Effect of CO2 enrichment on the glucosinolate contents under different nitrogen levels in bolting stem of Chinese kale -LRB- Brassica alboglabra L. -RRB- .
19694782	0	nitrogen	12,20	CO2	68,71	nitrogen	CO2	MESH:D009584	717	Chemical	Gene	review|nmod|START_ENTITY enrichment|nsubj|review enrichment|parataxis|offset offset|nsubjpass|sink sink|compound|END_ENTITY	A review of nitrogen enrichment effects on three biogenic GHGs : the CO2 sink may be largely offset by stimulated N2O and CH4 emission .
20487311	0	nitrogen	51,59	CO2	32,35	nitrogen	CO2	MESH:D009584	717	Chemical	Gene	cycling|compound|START_ENTITY effects|nmod|cycling effects|nmod|END_ENTITY	Contrasting effects of elevated CO2 and warming on nitrogen cycling in a semiarid grassland .
20627898	0	nitrogen	120,128	CO2	30,33	nitrogen	CO2	MESH:D009584	717	Chemical	Gene	content|compound|START_ENTITY reduced|dobj|content reduced|nsubj|Effects Effects|nmod|END_ENTITY	Effects of elevated root zone CO2 and air temperature on photosynthetic gas exchange , nitrate uptake , and total reduced nitrogen content in aeroponically grown lettuce plants .
20974944	0	nitrogen	62,70	CO2	0,3	nitrogen	CO2	MESH:D009584	717	Chemical	Gene	availability|compound|START_ENTITY constrained|nmod|availability constrained|nsubj|enhancement enhancement|nummod|END_ENTITY	CO2 enhancement of forest productivity constrained by limited nitrogen availability .
22961365	0	nitrogen	60,68	CO2	21,24	nitrogen	CO2	MESH:D009584	717	Chemical	Gene	genes|compound|START_ENTITY abundance|nmod|genes impacts|dobj|abundance impacts|nsubj|END_ENTITY	Elevated atmospheric CO2 impacts abundance and diversity of nitrogen cycling functional genes in soil .
23529747	0	nitrogen	52,60	CO2	0,3	nitrogen	CO2	MESH:D009584	717	Chemical	Gene	cycle|compound|START_ENTITY affected|nmod|cycle affected|nsubj|emissions emissions|nummod|END_ENTITY	CO2 emissions from land-use change affected more by nitrogen cycle , than by the choice of land-cover data .
23567711	0	nitrogen	118,126	CO2	156,159	nitrogen	CO2	MESH:D009584	717	Chemical	Gene	limitation|compound|START_ENTITY cultivation|nmod|limitation strategy|nmod|cultivation pyrenoidosa|nmod|strategy productivity|nmod|pyrenoidosa control|nsubj|productivity control|nmod|END_ENTITY	Enhanced lipid productivity of Chlorella pyrenoidosa through the culture strategy of semi-continuous cultivation with nitrogen limitation and pH control by CO2 .
24311131	0	nitrogen	11,19	CO2	76,79	nitrogen	CO2	MESH:D009584	717	Chemical	Gene	Effects|nmod|START_ENTITY supply|nsubj|Effects supply|nmod|END_ENTITY	Effects of nitrogen supply on the acclimation of photosynthesis to elevated CO2 .
24501068	0	nitrogen	25,33	CO2	170,173	nitrogen	CO2	MESH:D009584	717	Chemical	Gene	deposition|compound|START_ENTITY effects|nmod|deposition Assessing|dobj|effects Assessing|nmod|conditions conditions|compound|END_ENTITY	Assessing the effects of nitrogen deposition and climate on carbon_isotope_discrimination and intrinsic water-use efficiency of angiosperm and conifer trees under rising CO2 conditions .
25392967	0	nitrogen	155,163	CO2	59,62	nitrogen	CO2	MESH:D009584	717	Chemical	Gene	competition|nmod|START_ENTITY trees|nmod|competition model|nmod|trees storage|dep|model storage|nmod|END_ENTITY	Increased forest carbon storage with increased atmospheric CO2 despite nitrogen limitation : a game-theoretic allocation model for trees in competition for nitrogen and light .
25392967	0	nitrogen	71,79	CO2	59,62	nitrogen	CO2	MESH:D009584	717	Chemical	Gene	limitation|compound|START_ENTITY END_ENTITY|nmod|limitation	Increased forest carbon storage with increased atmospheric CO2 despite nitrogen limitation : a game-theoretic allocation model for trees in competition for nitrogen and light .
25755253	0	nitrogen	59,67	CO2	45,48	nitrogen	CO2	MESH:D009584	717	Chemical	Gene	source|compound|START_ENTITY depend|nmod|source depend|nsubj|Responses Responses|nmod|END_ENTITY	Responses of Arabidopsis and wheat to rising CO2 depend on nitrogen source and nighttime CO2 levels .
25846203	0	nitrogen	15,23	CO2	73,76	nitrogen	CO2	MESH:D009584	717	Chemical	Gene	acquisition|compound|START_ENTITY Constraints|nmod|acquisition Constraints|nmod|END_ENTITY	Constraints to nitrogen acquisition of terrestrial plants under elevated CO2 .
26144215	0	nitrogen	98,106	CO2	119,122	nitrogen	CO2	MESH:D009584	717	Chemical	Gene	content|compound|START_ENTITY content|nmod|adsorption adsorption|compound|END_ENTITY	A one-step carbonization route towards nitrogen-doped porous carbon hollow spheres with ultrahigh nitrogen content for CO2 adsorption .
26217886	0	nitrogen	15,23	CO2	70,73	nitrogen	CO2	MESH:D009584	717	Chemical	Gene	Development|nmod|START_ENTITY enriched|nsubj|Development enriched|nmod|capture capture|compound|END_ENTITY	Development of nitrogen enriched nanostructured carbon adsorbents for CO2 capture .
26272874	0	nitrogen	126,134	CO2	32,35	nitrogen	CO2	MESH:D009584	717	Chemical	Gene	concentrations|compound|START_ENTITY clipping|nmod|concentrations clipping|nsubj|Effects Effects|nmod|concentrations concentrations|compound|END_ENTITY	Effects of elevated atmospheric CO2 concentrations , clipping regimen and differential day/night atmospheric warming on tissue nitrogen concentrations of a perennial pasture grass .
26381794	0	nitrogen	14,22	CO2	175,178	nitrogen	CO2	MESH:D009584	717	Chemical	Gene	efficiency|compound|START_ENTITY Variations|nmod|efficiency reflect|nsubj|Variations reflect|advcl|reflect reflect|dobj|lineage lineage|nmod|grasses grasses|nmod|END_ENTITY	Variations in nitrogen use efficiency reflect the biochemical subtype while variations in water use efficiency reflect the evolutionary lineage of C4 grasses at inter-glacial CO2 .
26577708	0	nitrogen	32,40	CO2	9,12	nitrogen	CO2	MESH:D009584	717	Chemical	Gene	accumulation|compound|START_ENTITY promotes|dobj|accumulation promotes|nsubj|END_ENTITY	Elevated CO2 promotes long-term nitrogen accumulation only in combination with nitrogen addition .
26577708	0	nitrogen	79,87	CO2	9,12	nitrogen	CO2	MESH:D009584	717	Chemical	Gene	addition|compound|START_ENTITY combination|nmod|addition promotes|nmod|combination promotes|nsubj|END_ENTITY	Elevated CO2 promotes long-term nitrogen accumulation only in combination with nitrogen addition .
26656752	0	nitrogen	57,65	CO2	43,46	nitrogen	CO2	MESH:D009584	717	Chemical	Gene	inputs|compound|START_ENTITY vary|nmod|inputs vary|nsubj|responses responses|nmod|END_ENTITY	Plant stoichiometric responses to elevated CO2 vary with nitrogen and phosphorus inputs : Evidence from a global-scale meta-analysis .
20673806	0	nitrogen	55,63	Gat1	40,44	nitrogen	Gat1	MESH:D009584	6529	Chemical	Gene	uptake|compound|START_ENTITY regulates|dobj|uptake regulates|nsubj|END_ENTITY	The GATA-type transcriptional activator Gat1 regulates nitrogen uptake and metabolism in the human pathogen Cryptococcus_neoformans .
22405069	0	nitrogen	29,37	Klf15	0,5	nitrogen	Klf15	MESH:D009584	28999	Chemical	Gene	homeostasis|compound|START_ENTITY orchestrates|dobj|homeostasis orchestrates|nsubj|END_ENTITY	Klf15 orchestrates circadian nitrogen homeostasis .
7240099	0	nitrogen	106,114	L-asparaginase	14,28	nitrogen	L-asparaginase	MESH:D009584	80150	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of L-asparaginase in a Chlamydomonas species in response to ambient concentrations of combined nitrogen .
10719002	0	nitrogen	26,34	NAD-ME	69,75	nitrogen	NAD-ME	MESH:D009584	4200	Chemical	Gene	Relationship|nmod|START_ENTITY Relationship|nmod|END_ENTITY	Relationship between leaf nitrogen and photosynthetic rate for three NAD-ME and three NADP-ME C4 grasses .
8901135	0	nitrogen	40,48	NIT2	29,33	nitrogen	NIT2	MESH:D009584	52633(Tax:10090)	Chemical	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Identification of the native NIT2 major nitrogen regulatory protein in nuclear extracts of Neurospora_crassa .
9171427	0	nitrogen	29,37	Nil2p	20,25	nitrogen	Nil2p	MESH:D009584	853334(Tax:4932)	Chemical	Gene	regulation|compound|START_ENTITY Role|nmod|regulation Role|nmod|END_ENTITY	Role of GATA factor Nil2p in nitrogen regulation of gene expression in Saccharomyces_cerevisiae .
3356071	0	nitrogen	107,115	O6-methylguanine-DNA_methyltransferase	22,60	nitrogen	O6-methylguanine-DNA methyltransferase	MESH:D009584	17314(Tax:10090)	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|induction induction|nmod|END_ENTITY	In vitro induction of O6-methylguanine-DNA_methyltransferase in C3H/10T1/2 cells by X-rays is inhibited by nitrogen .
22246635	0	nitrogen	35,43	Sea	66,69	nitrogen	Sea	MESH:D009584	6395	Chemical	Gene	cycling|compound|START_ENTITY cycling|nmod|END_ENTITY	The effects of hypoxia on sediment nitrogen cycling in the Baltic Sea .
14500751	7	nitrogen	1307,1315	TH	1268,1270	nitrogen	TH	MESH:D009584	7054	Chemical	Gene	species|compound|START_ENTITY END_ENTITY|nmod|species	However , dithiothreitol prevents and reverses these effects on TH of tetrahydrobiopterin and reactive nitrogen species .
20704717	0	nitrogen	89,97	bZIP1	79,84	nitrogen	bZIP1	MESH:D009584	835005(Tax:3702)	Chemical	Gene	regulation|compound|START_ENTITY END_ENTITY|nmod|regulation	Modeling the global effect of the basic-leucine_zipper_transcription_factor_1 -LRB- bZIP1 -RRB- on nitrogen and light regulation in Arabidopsis .
11423323	0	nitrogen	23,31	carbamoyl_phosphate_synthetase_III	43,77	nitrogen	carbamoyl phosphate synthetase III	MESH:D009584	100136758(Tax:8022)	Chemical	Gene	activity|compound|START_ENTITY activity|dep|END_ENTITY	Effects of exercise on nitrogen excretion , carbamoyl_phosphate_synthetase_III activity and related urea cycle enzymes in muscle and liver tissues of juvenile rainbow_trout -LRB- Oncorhynchus_mykiss -RRB- .
2882693	0	nitrogen	53,61	dipeptidyl_peptidase_IV	8,31	nitrogen	dipeptidyl peptidase IV	MESH:D009584	100341424(Tax:9986)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of dipeptidyl_peptidase_IV in uptake of peptide nitrogen from beta-casomorphin in rabbit renal BBMV .
16663876	0	nitrogen	48,56	glutamate_dehydrogenase	21,44	nitrogen	glutamate dehydrogenase	MESH:D009584	100856888	Chemical	Gene	metabolism|compound|START_ENTITY role|nmod|metabolism role|nmod|END_ENTITY	Differential role of glutamate_dehydrogenase in nitrogen metabolism of maize tissues .
1212501	0	nitrogen	51,59	growth_hormone	29,43	nitrogen	growth hormone	MESH:D009584	81668(Tax:10116)	Chemical	Gene	balance|compound|START_ENTITY END_ENTITY|nmod|balance	-LSB- The effects of arginine and growth_hormone on the nitrogen balance of rats -RSB- .
7642277	0	nitrogen	111,119	interleukin_6	87,100	nitrogen	interleukin 6	MESH:D009584	16193(Tax:10090)	Chemical	Gene	intermediates|compound|START_ENTITY intermediates|amod|END_ENTITY	Mycobacterial 65-kilodalton heat_shock protein induces tumor_necrosis_factor_alpha and interleukin_6 , reactive nitrogen intermediates , and toxoplasmastatic activity in murine peritoneal macrophages .
10894808	0	nitrogen	49,57	myeloperoxidase	20,35	nitrogen	myeloperoxidase	MESH:D009584	4353	Chemical	Gene	species|compound|START_ENTITY species|amod|END_ENTITY	Oxidation of LDL by myeloperoxidase and reactive nitrogen species : reaction pathways and antioxidant protection .
15354951	0	nitrogen	11,19	myeloperoxidase	55,70	nitrogen	myeloperoxidase	MESH:D009584	4353	Chemical	Gene	Oxides|nmod|START_ENTITY Oxides|nmod|cofactors cofactors|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Oxides of nitrogen -LRB- NO * and NO2 - -RRB- as cofactors of the myeloperoxidase system -RSB- .
2137552	0	nitrogen	17,25	nit-2	0,5	nitrogen	nit-2	MESH:D009584	56954	Chemical	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	nit-2 , the major nitrogen regulatory gene of Neurospora_crassa , encodes a protein with a putative zinc finger DNA-binding domain .
2999766	0	nitrogen	12,20	ntrA	38,42	nitrogen	ntrA	MESH:D009584	257194	Chemical	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Products of nitrogen regulatory genes ntrA and ntrC of enteric bacteria activate glnA transcription in vitro : evidence that the ntrA product is a sigma factor .
18593147	0	nitrogen	46,54	spin	91,95	nitrogen	spin	MESH:D009584	10927	Chemical	Gene	interaction|compound|START_ENTITY interaction|nmod|END_ENTITY	High-field EPR and ESEEM investigation of the nitrogen quadrupole interaction of nitroxide spin labels in disordered solids : toward differentiation between polarity and proticity matrix effects on protein function .
2918503	0	nitrogen	56,64	thymidylate_synthase	23,43	nitrogen	thymidylate synthase	MESH:D009584	22171(Tax:10090)	Chemical	Gene	inhibitors|dep|START_ENTITY inhibitors|compound|END_ENTITY	Quinazoline antifolate thymidylate_synthase inhibitors : nitrogen , oxygen , sulfur , and chlorine substituents in the C2 position .
18842737	0	nitrogen	107,115	tumor_necrosis_factor_alpha	15,42	nitrogen	tumor necrosis factor alpha	MESH:D009584	21926(Tax:10090)	Chemical	Gene	production|nmod|START_ENTITY END_ENTITY|nmod|production	Enhancement by tumor_necrosis_factor_alpha of dengue virus-induced endothelial cell production of reactive nitrogen and oxygen species is key to hemorrhage development .
3883144	0	nitrogen_dioxide	37,53	umuC	13,17	nitrogen dioxide	umuC	MESH:D009585	7693072(Tax:90371)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Induction of umuC gene expression by nitrogen_dioxide in Salmonella_typhimurium .
7579417	0	nitrogen_monoxide	39,56	transferrin	60,71	nitrogen monoxide	transferrin	MESH:D009569	7018	Chemical	Gene	START_ENTITY|nmod|uptake uptake|compound|END_ENTITY	The effect of redox-related species of nitrogen_monoxide on transferrin and iron uptake and cellular proliferation of erythroleukemia -LRB- K562 -RRB- cells .
12079429	0	nitrogen_oxides	46,61	MEKK1	100,105	nitrogen oxides	MEKK1	MESH:D009589	4214	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Induced proliferation of human MRC-5 cells by nitrogen_oxides via direct and indirect activation of MEKK1 , JNK , and p38 signals .
2109093	0	nitrogen_oxides	31,46	interferon_gamma	62,78	nitrogen oxides	interferon gamma	MESH:D009589	3458	Chemical	Gene	START_ENTITY|nmod|response response|nmod|END_ENTITY	Endothelial cell production of nitrogen_oxides in response to interferon_gamma in combination with tumor necrosis factor , interleukin-1 , or endotoxin .
3080924	0	nitroglycerin	42,55	Methemoglobin	0,13	nitroglycerin	Methemoglobin	MESH:D005996	3048	Chemical	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	Methemoglobin levels following sublingual nitroglycerin in human volunteers .
7880995	0	nitroglycerin	47,60	Methemoglobin	0,13	nitroglycerin	Methemoglobin	MESH:D005996	3048	Chemical	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	Methemoglobin levels during prolonged combined nitroglycerin and sodium_nitroprusside infusions in infants after cardiac surgery .
11240977	0	nitroglycerin	52,65	angiotensin_II	10,24	nitroglycerin	angiotensin II	MESH:D005996	183	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of angiotensin_II on venodilator response to nitroglycerin .
2535309	0	nitroglycerin	71,84	atrial_natriuretic_factor	26,51	nitroglycerin	atrial natriuretic factor	MESH:D005996	4878	Chemical	Gene	comparison|nmod|START_ENTITY properties|dep|comparison properties|nmod|END_ENTITY	Vasodilator properties of atrial_natriuretic_factor : a comparison with nitroglycerin , nitroprusside , and phentolamine during cardiopulmonary bypass .
11521755	0	nitroglycerin	24,37	calcitonin_gene-related_peptide	53,84	nitroglycerin	calcitonin gene-related peptide	MESH:D005996	24241(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY mediated|nsubjpass|effect mediated|nmod|END_ENTITY	The depressor effect of nitroglycerin is mediated by calcitonin_gene-related_peptide .
11557266	0	nitroglycerin	82,95	calcitonin_gene-related_peptide	15,46	nitroglycerin	calcitonin gene-related peptide	MESH:D005996	24241(Tax:10116)	Chemical	Gene	Involvement|acl|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of calcitonin_gene-related_peptide in the development of tolerance to nitroglycerin in the rat .
11937102	0	nitroglycerin	25,38	calcitonin_gene-related_peptide	85,116	nitroglycerin	calcitonin gene-related peptide	MESH:D005996	24241(Tax:10116)	Chemical	Gene	Reversal|acl|START_ENTITY Reversal|dep|role role|nmod|END_ENTITY	Reversal of tolerance to nitroglycerin with N-acetylcysteine or captopril : a role of calcitonin_gene-related_peptide .
14653081	0	nitroglycerin	12,25	calcitonin_gene-related_peptide	36,67	nitroglycerin	calcitonin gene-related peptide	MESH:D005996	796	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of nitroglycerin on plasma calcitonin_gene-related_peptide and endothelin in congestive_heart_failure -RSB- .
15689192	0	nitroglycerin	129,142	calcitonin_gene-related_peptide	47,78	nitroglycerin	calcitonin gene-related peptide	MESH:D005996	796	Chemical	Gene	headache|nmod|START_ENTITY headache|amod|END_ENTITY	Sumatriptan causes parallel decrease in plasma calcitonin_gene-related_peptide -LRB- CGRP -RRB- concentration and migraine headache during nitroglycerin induced migraine attack .
17804099	0	nitroglycerin	25,38	calcitonin_gene-related_peptide	67,98	nitroglycerin	calcitonin gene-related peptide	MESH:D005996	24241(Tax:10116)	Chemical	Gene	Reversal|acl|START_ENTITY Reversal|dep|role role|nmod|END_ENTITY	Reversal of tolerance to nitroglycerin with vinpocetine : a role of calcitonin_gene-related_peptide .
19576883	0	nitroglycerin	92,105	calcitonin_gene-related_peptide	149,180	nitroglycerin	calcitonin gene-related peptide	MESH:D005996	24241(Tax:10116)	Chemical	Gene	biotransformation|compound|START_ENTITY Comparing|nmod|biotransformation Comparing|nmod|END_ENTITY	Comparing the role of glutathione-S-transferase and mitochondrial_aldehyde_dehydrogenase in nitroglycerin biotransformation and the correlation with calcitonin_gene-related_peptide .
24256609	0	nitroglycerin	108,121	calcitonin_gene-related_peptide	4,35	nitroglycerin	calcitonin gene-related peptide	MESH:D005996	24241(Tax:10116)	Chemical	Gene	infusion|compound|START_ENTITY decreases|nmod|infusion decreases|nsubj|MK-8825 MK-8825|amod|END_ENTITY	The calcitonin_gene-related_peptide receptor antagonist MK-8825 decreases spinal trigeminal activity during nitroglycerin infusion .
7537618	0	nitroglycerin	67,80	calcitonin_gene-related_peptide	122,153	nitroglycerin	calcitonin gene-related peptide	MESH:D005996	100124407(Tax:9823)	Chemical	Gene	responses|amod|START_ENTITY Early|nmod|responses Early|nmod|END_ENTITY	Early endotoxic_shock results in enhanced vasodilator responses to nitroglycerin but unaltered responses to neuropeptides calcitonin_gene-related_peptide and substance P. To determine the role that vasoactive neuropeptides , calcitonin_gene-related_peptide , and substance P play in tissue-blood flow regulation during early septic_shock , we examined the responsiveness of arteries removed from pigs 3 h after administration of Escherichia_coli lipopolysaccharide or saline vehicle .
3929581	0	nitroglycerin	46,59	methemoglobin	63,76	nitroglycerin	methemoglobin	MESH:D005996	3048	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|compound|END_ENTITY	Effects of continuous infusion of intravenous nitroglycerin on methemoglobin levels .
11043526	0	nitroglycerin	9,22	nNOS	33,37	nitroglycerin	nNOS	MESH:D005996	24598(Tax:10116)	Chemical	Gene	increases|compound|START_ENTITY END_ENTITY|nsubj|increases	Systemic nitroglycerin increases nNOS levels in rat trigeminal nucleus caudalis .
20456906	0	nitroglycerin	58,71	vasopressin	26,37	nitroglycerin	vasopressin	MESH:D005996	551	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|addition addition|nmod|plus plus|compound|END_ENTITY	Effect of the addition of vasopressin or vasopressin plus nitroglycerin to epinephrine on arterial blood pressure during cardiopulmonary resuscitation in humans .
2491934	0	nitroglycerin	25,38	vasopressin	86,97	nitroglycerin	vasopressin	MESH:D005996	551	Chemical	Gene	infusion|nmod|START_ENTITY infusion|acl|offset offset|dobj|effects effects|nmod|END_ENTITY	Simultaneous infusion of nitroglycerin and nitroprusside to offset adverse effects of vasopressin during portosystemic shunting .
2511136	0	nitroglycerin	27,40	vasopressin	44,55	nitroglycerin	vasopressin	MESH:D005996	551	Chemical	Gene	START_ENTITY|nmod|infusion infusion|compound|END_ENTITY	Association of transdermal nitroglycerin to vasopressin infusion in the treatment of variceal_hemorrhage : a placebo-controlled clinical trial .
3086204	0	nitroglycerin	55,68	vasopressin	22,33	nitroglycerin	vasopressin	MESH:D005996	551	Chemical	Gene	trial|nmod|START_ENTITY trial|nmod|END_ENTITY	A randomized trial of vasopressin and vasopressin plus nitroglycerin in the control of acute variceal_hemorrhage .
22352680	0	nitroglycerine	67,81	brain_natriuretic_peptide	40,65	nitroglycerine	brain natriuretic peptide	CHEBI:28787	487441(Tax:9615)	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|END_ENTITY	The differential effects of recombinant brain_natriuretic_peptide , nitroglycerine and dihydralazine on systemic oxygen delivery and gastric mucosal microvascular oxygenation in dogs .
3880276	0	nitrone	14,21	spin	22,26	nitrone	spin	null	10927	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nsubj|effect	The effect of nitrone spin trapping agents on red cell glucose metabolism .
18436984	0	nitronium	15,24	fibrinogen	82,92	nitronium	fibrinogen	null	2244	Chemical	Gene	ion|compound|START_ENTITY effects|nmod|ion effects|nmod|END_ENTITY	The effects of nitronium ion on nitration , carbonylation and coagulation of human fibrinogen .
1537571	0	nitrosourea	65,76	glutathione_reductase	14,35	nitrosourea	glutathione reductase	null	100757970	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Inhibition of glutathione_reductase activity by a carbamoylating nitrosourea : effect on cellular radiosensitivity .
9639692	0	nitrosoureas	55,67	O6-methylguanine-DNA_methyltransferase	113,151	nitrosoureas	O6-methylguanine-DNA methyltransferase	null	4255	Chemical	Gene	START_ENTITY|nmod|transfer transfer|nmod|END_ENTITY	Efficient protection of cells from the genotoxicity of nitrosoureas by the retrovirus-mediated transfer of human O6-methylguanine-DNA_methyltransferase using bicistronic vectors with human multidrug resistance gene 1 .
3759562	0	nitrosoureas	77,89	glutathione_reductase	30,51	nitrosoureas	glutathione reductase	null	14782(Tax:10090)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Carbamoylation , inhibition of glutathione_reductase and chemopotentiation of nitrosoureas by misonidazole .
20490401	0	nitrosyl	15,23	myoglobin	35,44	nitrosyl	myoglobin	CHEBI:16480	4151	Chemical	Gene	complex|amod|START_ENTITY complex|nmod|END_ENTITY	Revisiting the nitrosyl complex of myoglobin by high-field pulse EPR spectroscopy and quantum mechanical calculations .
12069071	0	nitrotyrosine	17,30	HPLC-ECD	34,42	nitrotyrosine	HPLC-ECD	null	70601(Tax:10090)	Chemical	Gene	Determination|nmod|START_ENTITY Determination|nmod|END_ENTITY	Determination of nitrotyrosine by HPLC-ECD and its application .
20357221	0	nitrotyrosine	92,105	PARP	76,80	nitrotyrosine	PARP	null	25591(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	New therapeutic and biomarker discovery for peripheral_diabetic_neuropathy : PARP inhibitor , nitrotyrosine , _ and_tumor_necrosis_factor - -LCB- alpha -RCB- .
1677218	0	nitrous_oxide	46,59	CD-1	135,139	nitrous oxide	CD-1	MESH:D009609	111334(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|compound|END_ENTITY	Effects of repeated intermittent exposures to nitrous_oxide on central neurotransmitters and hepatic methionine_synthetase activity in CD-1 mice .
12960557	0	nitrous_oxide	70,83	Corticotropin-releasing_factor	0,30	nitrous oxide	Corticotropin-releasing factor	MESH:D009609	81648(Tax:10116)	Chemical	Gene	action|nmod|START_ENTITY mediates|dobj|action mediates|nsubj|END_ENTITY	Corticotropin-releasing_factor mediates the antinociceptive action of nitrous_oxide in rats .
1751264	0	nitrous_oxide	136,149	P300	40,44	nitrous oxide	P300	MESH:D009609	2033	Chemical	Gene	concentrations|nmod|START_ENTITY potential|nmod|concentrations Changes|nmod|potential Changes|nmod|component component|compound|END_ENTITY	Changes in amplitude and latency of the P300 component of the auditory evoked potential with sedative and anaesthetic concentrations of nitrous_oxide .
2446836	0	nitrous_oxide	15,28	P300	32,36	nitrous oxide	P300	MESH:D009609	2033	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of nitrous_oxide on P300 and reaction_time .
2289052	1	nitrous_oxide	213,226	methionine_synthase	190,209	nitrous oxide	methionine synthase	MESH:D009609	397300(Tax:9823)	Chemical	Gene	tissues|nmod|START_ENTITY tissues|nmod|inactivation inactivation|nmod|END_ENTITY	Concentrations in pig tissues after inactivation of methionine_synthase by nitrous_oxide .
2753341	0	nitrous_oxide	26,39	methionine_synthase	69,88	nitrous oxide	methionine synthase	MESH:D009609	81522(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activity activity|amod|END_ENTITY	The inhibitory effects of nitrous_oxide and methylmercury in vivo on methionine_synthase -LRB- EC 2.1.1.13 -RRB- activity in the brain , liver , ovary and spinal cord of the rat .
6882609	0	nitrous_oxide	31,44	methionine_synthase	48,67	nitrous oxide	methionine synthase	MESH:D009609	81522(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effects of chronic exposure to nitrous_oxide on methionine_synthase activity .
7363899	0	nitrous_oxide	39,52	methionine_synthase	16,35	nitrous oxide	methionine synthase	MESH:D009609	81522(Tax:10116)	Chemical	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of methionine_synthase by nitrous_oxide .
9278558	0	nitrous_oxide	55,68	methionine_synthase	85,104	nitrous oxide	methionine synthase	MESH:D009609	81522(Tax:10116)	Chemical	Gene	inactivation|amod|START_ENTITY inactivation|nmod|leads leads|amod|END_ENTITY	Compartmentation_of_folate_metabolism in rat pancreas : nitrous_oxide inactivation of methionine_synthase leads to accumulation of 5-methyltetrahydrofolate in cytosol .
15993935	0	nitrous_oxide	43,56	nitric_oxide_synthase	84,105	nitrous oxide	nitric oxide synthase	MESH:D009609	18125(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Correlation of inbred mouse sensitivity to nitrous_oxide antinociception with brain nitric_oxide_synthase activity following exposure to nitrous_oxide .
7128805	0	nitroxinil	63,73	cytochrome_P-450	94,110	nitroxinil	cytochrome P-450	MESH:D009611	25251(Tax:10116)	Chemical	Gene	metabolism|nmod|START_ENTITY microsomal|nsubj|metabolism microsomal|xcomp|END_ENTITY	The reductive metabolism of the nitroaromatic flukicidal agent nitroxinil by liver microsomal cytochrome_P-450 .
16781460	0	nitroxyl	54,62	Cathepsin_B	0,11	nitroxyl	Cathepsin B	MESH:C039900	1508	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Cathepsin_B is a differentiation-resistant target for nitroxyl -LRB- HNO -RRB- in THP-1 monocyte/macrophages .
10680717	0	nitroxyl	12,20	N-acetyl-L-cysteine	64,83	nitroxyl	N-acetyl-L-cysteine	MESH:C039900	7504	Chemical	Gene	Reaction|nmod|START_ENTITY Reaction|nmod|END_ENTITY	Reaction of nitroxyl , an aldehyde dehydrogenase inhibitor , with N-acetyl-L-cysteine .
16297875	0	nitroxyl	67,75	Prx_I	7,12	nitroxyl	Prx I	MESH:C039900	18477(Tax:10090)	Chemical	Gene	radicals|amod|START_ENTITY END_ENTITY|nmod|radicals	Tissue Prx_I in the protection against Fe-NTA and the reduction of nitroxyl radicals .
7783118	0	nitroxyl	12,20	aldehyde_dehydrogenase	34,56	nitroxyl	aldehyde dehydrogenase	MESH:C039900	25375(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Prodrugs of nitroxyl as potential aldehyde_dehydrogenase inhibitors vis-a-vis vascular smooth muscle relaxants .
9667978	0	nitroxyl	12,20	aldehyde_dehydrogenase	77,99	nitroxyl	aldehyde dehydrogenase	MESH:C039900	25375(Tax:10116)	Chemical	Gene	Prodrugs|nmod|START_ENTITY latentiated|nsubj|Prodrugs latentiated|dobj|inhibitors inhibitors|nmod|END_ENTITY	Prodrugs of nitroxyl and nitrosobenzene as cascade latentiated inhibitors of aldehyde_dehydrogenase .
17678614	0	nitroxyl	62,70	glyceraldehyde-3-phosphate_dehydrogenase	18,58	nitroxyl	glyceraldehyde-3-phosphate dehydrogenase	MESH:C039900	2597	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	The inhibition of glyceraldehyde-3-phosphate_dehydrogenase by nitroxyl -LRB- HNO -RRB- .
1796924	0	nizatidine	31,41	gastrin	78,85	nizatidine	gastrin	MESH:D016567	25320(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|level level|compound|END_ENTITY	Effects of successive doses of nizatidine , cimetidine and ranitidine on serum gastrin level and gastric_acid secretion .
8963030	0	nizatidine	10,20	gastrin	99,106	nizatidine	gastrin	MESH:D016567	2520	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|concentrations concentrations|compound|END_ENTITY	Effect of nizatidine and ranitidine on 24 hour intragastric pH , pepsin , prostaglandin_E2 and serum gastrin concentrations in healthy volunteers .
17373552	0	nobiletin	59,68	Tyrosinase	0,10	nobiletin	Tyrosinase	MESH:C008661	22173(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|amod|END_ENTITY	Tyrosinase inhibitory effects and inhibition mechanisms of nobiletin and hesperidin from citrus peel crude extracts .
17373553	0	nobiletin	59,68	Tyrosinase	0,10	nobiletin	Tyrosinase	MESH:C008661	22173(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|amod|END_ENTITY	Tyrosinase inhibitory effects and inhibition mechanisms of nobiletin and hesperidin from citrus peel crude extracts .
23984517	0	nobiletin	26,35	cystic_fibrosis_transmembrane_conductance_regulator	39,90	nobiletin	cystic fibrosis transmembrane conductance regulator	MESH:C008661	1080	Chemical	Gene	START_ENTITY|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- The activation effect of nobiletin on cystic_fibrosis_transmembrane_conductance_regulator chloride channel -RSB- .
17586043	0	nociceptin	26,36	c-Fos	45,50	nociceptin	c-Fos	MESH:C096012	14281(Tax:10090)	Chemical	Gene	START_ENTITY|acl|induced induced|dobj|expression expression|amod|END_ENTITY	Nocistatin attenuated the nociceptin induced c-Fos expression in the mouse hippocampus .
15747831	0	nocodazole	11,21	STAT1	65,70	nocodazole	STAT1	MESH:D015739	6772	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	-LSB- Effect of nocodazole on the activation of transcription factors STAT1 and STAT3 in A431 cells -RSB- .
21385933	0	node	70,74	TGF-beta	19,27	node	TGF-beta	null	7040	Chemical	Gene	pathways|nmod|START_ENTITY pathways|amod|END_ENTITY	Involvement of the TGF-beta and beta-catenin pathways in pelvic lymph node metastasis in early-stage_cervical_cancer .
16080533	0	nomegestrol_acetate	33,52	sulfatase	11,20	nomegestrol acetate	sulfatase	MESH:C038501	347527	Chemical	Gene	Control|nmod|START_ENTITY Control|nmod|activity activity|amod|END_ENTITY	Control of sulfatase activity by nomegestrol_acetate in normal and cancerous human breast tissues .
3921593	0	nomifensine	11,22	prolactin	39,48	nomifensine	prolactin	MESH:D009627	5617	Chemical	Gene	Failure|nmod|START_ENTITY Failure|acl|reduce reduce|dobj|levels levels|compound|END_ENTITY	Failure of nomifensine to reduce serum prolactin levels in patients with hepatic_encephalopathy .
6771065	0	nomifensine	37,48	prolactin	14,23	nomifensine	prolactin	MESH:D009627	5617	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of prolactin secretion by nomifensine in man .
7202740	0	nomifensine	76,87	prolactin	9,18	nomifensine	prolactin	MESH:D009627	5617	Chemical	Gene	Tests|dep|START_ENTITY Tests|nmod|secretion secretion|compound|END_ENTITY	Tests of prolactin secretion in the diagnosis of hyperprolactinemic states : nomifensine and domperidone .
7301051	0	nomifensine	146,157	prolactin	53,62	nomifensine	prolactin	MESH:D009627	5617	Chemical	Gene	effect|nmod|START_ENTITY comparison|nmod|effect Effect|dep|comparison Effect|acl|acting acting|dobj|agonists agonists|nmod|secretion secretion|compound|END_ENTITY	Effect of two indirectly acting dopamine agonists on prolactin secretion in normo - and hyperprolactinemic subjects : comparison with the effect of nomifensine .
8794867	0	noncadherin	68,79	fascin	56,62	noncadherin	fascin	null	683788(Tax:10116)	Chemical	Gene	complex|compound|START_ENTITY END_ENTITY|nmod|complex	beta-Catenin associates with the actin-bundling protein fascin in a noncadherin complex .
15857980	0	noncognate	125,135	CD4	136,139	noncognate	CD4	null	12504(Tax:10090)	Chemical	Gene	activities|amod|START_ENTITY activities|compound|END_ENTITY	Roles of CD4 + T-cell-independent and - dependent antibody responses in the control of influenza virus infection : evidence for noncognate CD4 + T-cell activities that enhance the therapeutic activity of antiviral antibodies .
6759232	0	nonglucose	21,31	Insulin	0,7	nonglucose	Insulin	null	3630	Chemical	Gene	responses|xcomp|START_ENTITY responses|nsubj|END_ENTITY	Insulin responses to nonglucose stimuli in non-insulin-dependent_diabetes_mellitus during a tolbutamide infusion .
19880492	0	nonpeptidyl	12,23	thrombopoietin	42,56	nonpeptidyl	thrombopoietin	null	7066	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	A prototype nonpeptidyl , hydrazone class , thrombopoietin receptor agonist , SB-559457 , is toxic to primary human myeloid_leukemia cells .
18800759	0	nonquinone	70,80	Hsp90	81,86	nonquinone	Hsp90	null	3320	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Optimizing natural products by biosynthetic engineering : discovery of nonquinone Hsp90 inhibitors .
16468634	0	nonylphenol	12,23	PCNA	27,31	nonylphenol	PCNA	MESH:C025256	25737(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	-LSB- Effects of nonylphenol on PCNA expression and aromatase expression in reproductive system of F1 generation -RSB- .
22135911	0	nonylphenol	72,83	ghrelin	27,34	nonylphenol	ghrelin	MESH:C025256	59301(Tax:10116)	Chemical	Gene	evaluation|nmod|START_ENTITY radioimmunoassay|dep|evaluation radioimmunoassay|nmod|END_ENTITY	A radioimmunoassay for rat ghrelin : evaluation of method and effects of nonylphenol on ghrelin secretion in force-fed young rats .
22135911	0	nonylphenol	72,83	ghrelin	87,94	nonylphenol	ghrelin	MESH:C025256	59301(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	A radioimmunoassay for rat ghrelin : evaluation of method and effects of nonylphenol on ghrelin secretion in force-fed young rats .
17917294	0	nor-binaltorphimine	31,50	kappa_opioid_receptor	130,151	nor-binaltorphimine	kappa opioid receptor	MESH:C051844	4986	Chemical	Gene	analogs|amod|START_ENTITY oxidation|nmod|analogs affords|nsubj|oxidation affords|dobj|ligand ligand|nmod|END_ENTITY	Catalytic aerobic oxidation of nor-binaltorphimine -LRB- nor-BNI -RRB- analogs without 4,5-epoxy bridge affords a more selective ligand for kappa_opioid_receptor than the representative kappa antagonist nor-BNI .
23933210	0	nor-binaltorphimine	56,75	kappa_opioid_receptor	86,107	nor-binaltorphimine	kappa opioid receptor	MESH:C051844	18387(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Pharmacokinetic evidence for the long-lasting effect of nor-binaltorphimine , a potent kappa_opioid_receptor antagonist , in mice .
10622284	0	noradrenaline	84,97	ATP	73,76	noradrenaline	ATP	MESH:D009638	22293(Tax:10090)	Chemical	Gene	release|amod|START_ENTITY END_ENTITY|nmod|release	Participation of cAMP in the facilitatory action of beta,gamma-methylene _ ATP on the noradrenaline release from rabbit ear artery .
24194850	0	noradrenaline	16,29	Ang_II	0,6	noradrenaline	Ang II	MESH:D009638	183	Chemical	Gene	release|amod|START_ENTITY enhances|dobj|release enhances|nsubj|END_ENTITY	Ang_II enhances noradrenaline release from sympathetic nerve endings thus contributing to the up-regulation of metalloprotease-2 in aortic_dissection patients ' aorta wall .
11572794	0	noradrenaline	24,37	Angiotensin_II	0,14	noradrenaline	Angiotensin II	MESH:D009638	24179(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY enhances|dobj|release enhances|nsubj|END_ENTITY	Angiotensin_II enhances noradrenaline release from sympathetic nerves of the rat prostate via a novel angiotensin receptor : implications for the pathophysiology of benign_prostatic_hyperplasia .
1611472	0	noradrenaline	22,35	Angiotensin_II	0,14	noradrenaline	Angiotensin II	MESH:D009638	24179(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY evokes|dobj|release evokes|nsubj|END_ENTITY	Angiotensin_II evokes noradrenaline release from the paraventricular nucleus in conscious rats .
7904926	0	noradrenaline	35,48	Atrial_natriuretic_factor	0,25	noradrenaline	Atrial natriuretic factor	MESH:D009638	24602(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY inhibits|dobj|release inhibits|nsubj|END_ENTITY	Atrial_natriuretic_factor inhibits noradrenaline release in the presence of angiotensin_II_and_III in the rat hypothalamus .
8903325	0	noradrenaline	41,54	Atrial_natriuretic_peptide	0,26	noradrenaline	Atrial natriuretic peptide	MESH:D009638	24602(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Atrial_natriuretic_peptide regulation of noradrenaline release in the anterior_hypothalamic_area of spontaneously hypertensive rats .
11239919	0	noradrenaline	91,104	CA1	58,61	noradrenaline	CA1	MESH:D009638	310218(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY facilitation|nmod|release neurons|nmod|facilitation neurons|compound|END_ENTITY	Inhibition by L-3 ,4 - dihydroxyphenylalanine of hippocampal CA1 neurons with facilitation of noradrenaline and gamma-aminobutyric_acid release .
1884244	0	noradrenaline	20,33	CA1	63,66	noradrenaline	CA1	MESH:D009638	310218(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nsubj|effect	Increased effect of noradrenaline on synaptic responses in rat CA1 hippocampal area after adrenalectomy .
2873241	0	noradrenaline	11,24	CA1	69,72	noradrenaline	CA1	MESH:D009638	310218(Tax:10116)	Chemical	Gene	Actions|nmod|START_ENTITY recorded|nsubj|Actions recorded|nmod|neurones neurones|compound|END_ENTITY	Actions of noradrenaline recorded intracellularly in rat hippocampal CA1 pyramidal neurones , in vitro .
2999648	0	noradrenaline	11,24	CA1	55,58	noradrenaline	CA1	MESH:D009638	310218(Tax:10116)	Chemical	Gene	currents|amod|START_ENTITY currents|nmod|END_ENTITY	Effects of noradrenaline on some potassium currents in CA1 neurones in rat hippocampal slices .
7877726	0	noradrenaline	22,35	CA1	111,114	noradrenaline	CA1	MESH:D009638	310218(Tax:10116)	Chemical	Gene	affect|nsubj|START_ENTITY affect|dobj|release release|nmod|stimulation stimulation|nmod|cells cells|nummod|END_ENTITY	Decreased hippocampal noradrenaline does not affect corticosterone release following electrical stimulation of CA1 pyramidal cells .
9763638	0	noradrenaline	11,24	CA1	90,93	noradrenaline	CA1	MESH:D009638	310218(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|pH pH|nmod|END_ENTITY	Effects of noradrenaline on intracellular pH in acutely dissociated adult rat hippocampal CA1 neurones .
8431775	0	noradrenaline	40,53	Corticotropin-releasing_factor	0,30	noradrenaline	Corticotropin-releasing factor	MESH:D009638	81648(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY enhances|dobj|release enhances|nsubj|END_ENTITY	Corticotropin-releasing_factor enhances noradrenaline release in the rat hypothalamus assessed by intracerebral microdialysis .
1705122	0	noradrenaline	28,41	Endothelin-1	0,12	noradrenaline	Endothelin-1	MESH:D009638	281137(Tax:9913)	Chemical	Gene	stimulation|nmod|START_ENTITY stimulation|amod|END_ENTITY	Endothelin-1 stimulation of noradrenaline and adrenaline release from adrenal chromaffin cells .
3042578	0	noradrenaline	30,43	Insulin	0,7	noradrenaline	Insulin	MESH:D009638	3630	Chemical	Gene	response|compound|START_ENTITY modulates|dobj|response modulates|nsubj|END_ENTITY	Insulin modulates early-phase noradrenaline response to glucose ingestion in humans .
20036647	0	noradrenaline	17,30	Leptin	0,6	noradrenaline	Leptin	MESH:D009638	25608(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|modulates modulates|compound|END_ENTITY	Leptin modulates noradrenaline release in the paraventricular nucleus and plasma oxytocin levels in female rats : a microdialysis study .
18364034	0	noradrenaline	59,72	MMP2	26,30	noradrenaline	MMP2	MESH:D009638	17390(Tax:10090)	Chemical	Gene	upregulated|nmod|START_ENTITY upregulated|nsubjpass|END_ENTITY	Matrix metalloproteinases MMP2 and MMP9 are upregulated by noradrenaline in the mouse neuroendocrine_hypothalamus .
696418	0	noradrenaline	36,49	Renin	0,5	noradrenaline	Renin	MESH:D009638	5972	Chemical	Gene	START_ENTITY|nsubj|release release|compound|END_ENTITY	Renin release in relation to plasma noradrenaline during supine exercise in cardiac patients .
10704276	0	noradrenaline	37,50	Somatostatin	0,12	noradrenaline	Somatostatin	MESH:D009638	24797(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY inhibits|dobj|release inhibits|nsubj|END_ENTITY	Somatostatin inhibits the release of noradrenaline induced by electrical stimulation of the rat mesenteric artery .
1460089	0	noradrenaline	61,74	TNF-alpha	33,42	noradrenaline	TNF-alpha	MESH:D009638	24835(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Presynaptic inhibitory effect of TNF-alpha on the release of noradrenaline in isolated median eminence .
10844574	0	noradrenaline	26,39	Vasopressin	0,11	noradrenaline	Vasopressin	MESH:D009638	551	Chemical	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	Vasopressin regulation of noradrenaline release within the supraoptic nucleus .
1071652	0	noradrenaline	28,41	angiotensin_II	10,24	noradrenaline	angiotensin II	MESH:D009638	24179(Tax:10116)	Chemical	Gene	content|amod|START_ENTITY END_ENTITY|nmod|content	Effect of angiotensin_II on noradrenaline content in the rat hypothalamus .
10816333	0	noradrenaline	122,135	angiotensin_II	58,72	noradrenaline	angiotensin II	MESH:D009638	24179(Tax:10116)	Chemical	Gene	sensitivity|amod|START_ENTITY increase|nmod|sensitivity induce|dobj|increase induce|nsubj|treatments treatments|nmod|rats rats|nmod|END_ENTITY	Short treatments of normotensive and hypertensive rats by angiotensin_II and nitric_oxide inhibitor induce an increase of noradrenaline sensitivity in isolated vena portae preparations .
12644277	0	noradrenaline	24,37	angiotensin_II	90,104	noradrenaline	angiotensin II	MESH:D009638	24179(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY release|nmod|area area|acl|induced induced|nmod|activation activation|amod|END_ENTITY	Drinking attenuates the noradrenaline release in the lateral hypothalamic area induced by angiotensin_II activation of the subfornical organ in rats .
1305906	0	noradrenaline	44,57	angiotensin_II	11,25	noradrenaline	angiotensin II	MESH:D009638	24179(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of angiotensin_II on regional brain noradrenaline metabolism in non-stressed and stressed rats .
14570150	0	noradrenaline	85,98	angiotensin_II	53,67	noradrenaline	angiotensin II	MESH:D009638	24179(Tax:10116)	Chemical	Gene	uptake|amod|START_ENTITY effects|nmod|uptake effects|nmod|receptors receptors|amod|END_ENTITY	The effects of peptide and nonpeptide antagonists of angiotensin_II receptors on the noradrenaline uptake of different brain structures in rats with angiotensin_II-induced increase of water intake .
14647975	0	noradrenaline	101,114	angiotensin_II	68,82	noradrenaline	angiotensin II	MESH:D009638	24179(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY Influence|nmod|release Influence|nmod|facilitation facilitation|nmod|END_ENTITY	Influence of alpha2-autoreceptor stimulation on the facilitation by angiotensin_II and bradykinin of noradrenaline release .
16003188	0	noradrenaline	143,156	angiotensin_II	108,122	noradrenaline	angiotensin II	MESH:D009638	24179(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY modulate|dobj|release modulate|nsubj|generation generation|nmod|END_ENTITY	Angiotensin_I-converting_enzyme-dependent and neutral_endopeptidase-dependent generation and degradation of angiotensin_II contrarily modulate noradrenaline release : implications for vasopeptidase-inhibitor therapy ?
1743243	0	noradrenaline	56,69	angiotensin_II	14,28	noradrenaline	angiotensin II	MESH:D009638	183	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|END_ENTITY	The effect of angiotensin_II on haemodynamic and plasma noradrenaline responses to tyramine infusion in man .
1864961	0	noradrenaline	82,95	angiotensin_II	107,121	noradrenaline	angiotensin II	MESH:D009638	183	Chemical	Gene	START_ENTITY|dep|not not|nmod|END_ENTITY	Exogenous insulin augments in healthy volunteers the cardiovascular reactivity to noradrenaline but not to angiotensin_II .
20081258	0	noradrenaline	76,89	angiotensin_II	48,62	noradrenaline	angiotensin II	MESH:D009638	24179(Tax:10116)	Chemical	Gene	receptors|nmod|START_ENTITY receptors|amod|END_ENTITY	Effect of peptide and nonpeptide antagonists of angiotensin_II receptors on noradrenaline release in hypothalamus of rats with angiotensin_II-induced increase of water intake .
2632753	0	noradrenaline	104,117	angiotensin_II	81,95	noradrenaline	angiotensin II	MESH:D009638	183	Chemical	Gene	reactive|ccomp|START_ENTITY reactive|nmod|END_ENTITY	Large and small forearm arteries of essential hypertensives are less reactive to angiotensin_II than to noradrenaline .
2673114	0	noradrenaline	16,29	angiotensin_II	73,87	noradrenaline	angiotensin II	MESH:D009638	24179(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY Facilitation|nmod|release mediated|nsubjpass|Facilitation mediated|nmod|END_ENTITY	Facilitation of noradrenaline release by isoprenaline is not mediated by angiotensin_II in mouse atria and rat tail artery .
2692889	0	noradrenaline	16,29	angiotensin_II	93,107	noradrenaline	angiotensin II	MESH:D009638	24179(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY Facilitation|nmod|release isolated|nsubj|Facilitation isolated|ccomp|involve involve|dobj|formation formation|amod|END_ENTITY	Facilitation of noradrenaline release by isoprenaline in rat isolated atria does not involve angiotensin_II formation .
2833189	0	noradrenaline	62,75	angiotensin_II	89,103	noradrenaline	angiotensin II	MESH:D009638	24179(Tax:10116)	Chemical	Gene	1-adrenoceptors|nmod|START_ENTITY vascular|amod|1-adrenoceptors vascular|acl|released released|nmod|END_ENTITY	Stimulation of vascular postsynaptic alpha 1-adrenoceptors by noradrenaline , released by angiotensin_II in pithed rat preparations .
3024031	0	noradrenaline	74,87	angiotensin_II	121,135	noradrenaline	angiotensin II	MESH:D009638	24179(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY release|nmod|stimulation stimulation|nmod|synthesis synthesis|amod|END_ENTITY	Subendothelial beta_2-adrenoceptors in the rat vena cava : facilitation of noradrenaline release via local stimulation of angiotensin_II synthesis .
3440094	0	noradrenaline	43,56	angiotensin_II	14,28	noradrenaline	angiotensin II	MESH:D009638	183	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|END_ENTITY	The effect of angiotensin_II on endogenous noradrenaline release in man .
3907740	0	noradrenaline	80,93	angiotensin_II	54,68	noradrenaline	angiotensin II	MESH:D009638	24179(Tax:10116)	Chemical	Gene	responsiveness|amod|START_ENTITY effect|nmod|responsiveness alterations|dep|effect alterations|nmod|END_ENTITY	Dietary and pharmacological alterations in endogenous angiotensin_II : effect on noradrenaline pressor responsiveness in the rat .
4321672	0	noradrenaline	70,83	angiotensin_II	34,48	noradrenaline	angiotensin II	MESH:D009638	183	Chemical	Gene	-RSB-|amod|START_ENTITY uptake|nmod|-RSB- END_ENTITY|nmod|uptake	-LSB- Action , in vitro and in vivo , of angiotensin_II on cardiac uptake of noradrenaline -RSB- .
6096611	0	noradrenaline	107,120	angiotensin_II	91,105	noradrenaline	angiotensin II	MESH:D009638	24179(Tax:10116)	Chemical	Gene	blockade|amod|START_ENTITY blockade|nmod|END_ENTITY	Effect of chronic angiotensin-converting enzyme blockade on pressor responses to exogenous angiotensin_II , noradrenaline and vasopressin in deoxycorticosterone_acetate salt -LRB- DOCA -RRB- - induced hypertensive rats .
6099769	0	noradrenaline	72,85	angiotensin_II	11,25	noradrenaline	angiotensin II	MESH:D009638	24179(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY stimulated|dobj|release inhibitors|advcl|stimulated inhibitors|nsubj|Effects Effects|nmod|END_ENTITY	Effects of angiotensin_II and ACE inhibitors on electrically stimulated noradrenaline release from superfused rat brain slices .
7858867	0	noradrenaline	60,73	angiotensin_II	117,131	noradrenaline	angiotensin II	MESH:D009638	24179(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY Facilitation|nmod|release Facilitation|nmod|rat rat|nmod|formation formation|amod|END_ENTITY	Facilitation by procaterol , a beta-adrenoceptor agonist , of noradrenaline release in the pithed rat independently of angiotensin_II formation .
8025910	0	noradrenaline	28,41	angiotensin_II	10,24	noradrenaline	angiotensin II	MESH:D009638	183	Chemical	Gene	release|amod|START_ENTITY END_ENTITY|nmod|release	Effect of angiotensin_II on noradrenaline release in the human forearm .
8584237	0	noradrenaline	110,123	angiotensin_II	18,32	noradrenaline	angiotensin II	MESH:D009638	183	Chemical	Gene	release|amod|START_ENTITY transfected|nmod|release transfected|nsubj|effect effect|nmod|receptor receptor|amod|END_ENTITY	The effect of the angiotensin_II -LRB- AT1A -RRB- receptor stably transfected into human neuroblastoma SH-SY5Y cells on noradrenaline release and changes in intracellular calcium .
913046	0	noradrenaline	35,48	angiotensin_II	134,148	noradrenaline	angiotensin II	MESH:D009638	24179(Tax:10116)	Chemical	Gene	ions|compound|START_ENTITY ions|nmod|arteries arteries|nmod|concentrations concentrations|nmod|END_ENTITY	Potentiation of pressor effects of noradrenaline and potassium ions in the rat mesenteric arteries by physiological concentrations of angiotensin_II : effects of prostaglandin_E2 and cortisol .
7630431	0	noradrenaline	81,94	catechol-O-methyltransferase	27,55	noradrenaline	catechol-O-methyltransferase	MESH:D009638	24267(Tax:10116)	Chemical	Gene	Evidence|nmod|START_ENTITY Evidence|nmod|END_ENTITY	Evidence for saturation of catechol-O-methyltransferase by low concentrations of noradrenaline in perfused lungs of rats .
8003768	0	noradrenaline	30,43	corticotropin-releasing_factor	87,117	noradrenaline	corticotropin-releasing factor	MESH:D009638	81648(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY mediated|nsubjpass|release mediated|nmod|END_ENTITY	An interleukin-1_beta-induced noradrenaline release in the spleen is mediated by brain corticotropin-releasing_factor : an in vivo microdialysis study in conscious rats .
20966530	0	noradrenaline	82,95	corticotropin-releasing_hormone	49,80	noradrenaline	corticotropin-releasing hormone	MESH:D009638	81648(Tax:10116)	Chemical	Gene	neurons|amod|START_ENTITY neurons|amod|END_ENTITY	Stressor-responsive central nesfatin-1 activates corticotropin-releasing_hormone , noradrenaline and serotonin neurons and evokes hypothalamic-pituitary-adrenal_axis .
1922677	0	noradrenaline	96,109	gonadotrophin-releasing_hormone	39,70	noradrenaline	gonadotrophin-releasing hormone	MESH:D009638	25194(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of active immunization against gonadotrophin-releasing_hormone on the concentrations of noradrenaline , dopamine , 5-hydroxytryptamine and some of their metabolites in the brain and sexual organs of male rats .
7874313	0	noradrenaline	53,66	gp120	23,28	noradrenaline	gp120	MESH:D009638	3700	Chemical	Gene	release|compound|START_ENTITY potentiates|dobj|release potentiates|nsubj|END_ENTITY	HIV-1 envelope protein gp120 potentiates NMDA-evoked noradrenaline release by a direct action at rat hippocampal and cortical noradrenergic nerve endings .
15569098	0	noradrenaline	64,77	growth_hormone	95,109	noradrenaline	growth hormone	MESH:D009638	14599(Tax:10090)	Chemical	Gene	concentration|compound|START_ENTITY concentration|nmod|END_ENTITY	Reduced sympathetic responsiveness as well as plasma and tissue noradrenaline concentration in growth_hormone transgenic_mice .
11171092	0	noradrenaline	30,43	induced_cAMP_early_repressor	72,100	noradrenaline	induced cAMP early repressor	MESH:D009638	1390	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	As the proliferation promoter noradrenaline induces expression of ICER -LRB- induced_cAMP_early_repressor -RRB- in proliferative brown adipocytes , ICER may not be a universal tumour suppressor .
1979763	4	noradrenaline	906,919	insulin	967,974	noradrenaline	insulin	MESH:D009638	3630	Chemical	Gene	levels|compound|START_ENTITY higher|nsubj|levels higher|nmod|infusion infusion|nmod|END_ENTITY	The circulating noradrenaline levels were higher during the infusion of pork insulin which also yielded a more prominent response of pancreatic polypeptide and , after cessation of the insulin infusion , plasma cortisol was also higher following pork insulin .
7001180	0	noradrenaline	35,48	insulin	17,24	noradrenaline	insulin	MESH:D009638	3630	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Acute effects of insulin on plasma noradrenaline and the cardiovascular system .
7630433	0	noradrenaline	36,49	interleukin-1_beta	14,32	noradrenaline	interleukin-1 beta	MESH:D009638	24494(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY END_ENTITY|nmod|release	Inhibition by interleukin-1_beta of noradrenaline release in rat spleen : involvement of lymphocytes , NO and opioid receptors .
9718981	0	noradrenaline	39,52	interleukin-1_beta	17,35	noradrenaline	interleukin-1 beta	MESH:D009638	3553	Chemical	Gene	release|amod|START_ENTITY END_ENTITY|nmod|release	Acute effects of interleukin-1_beta on noradrenaline release from the human neuroblastoma cell line SH-SY5Y .
6652339	0	noradrenaline	9,22	monoamine_oxidase_A_and_B	52,77	noradrenaline	monoamine oxidase A and B	MESH:D009638	29253;25750	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	In vivo , noradrenaline is a substrate for rat brain monoamine_oxidase_A_and_B .
2259391	0	noradrenaline	14,27	neuropeptide_Y	39,53	noradrenaline	neuropeptide Y	MESH:D009638	109648(Tax:10090)	Chemical	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	Inhibition of noradrenaline release by neuropeptide_Y does not involve protein kinase C in mouse atria .
3659100	0	noradrenaline	64,77	neuropeptide_Y	19,33	noradrenaline	neuropeptide Y	MESH:D009638	24604(Tax:10116)	Chemical	Gene	action|nmod|START_ENTITY END_ENTITY|nmod|action	The involvement of neuropeptide_Y in the antimuricide action of noradrenaline injected into the medial amygdala of olfactory bulbectomized rats .
12679149	0	noradrenaline	18,31	nitric_oxide_synthase-2	57,80	noradrenaline	nitric oxide synthase-2	MESH:D009638	18126(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Responsiveness to noradrenaline in aorta from wild-type , nitric_oxide_synthase-2 , nitric_oxide synthase-3 and alpha2A/D-adrenoceptor knockout mice .
11323113	0	noradrenaline	69,82	nociceptin	36,46	noradrenaline	nociceptin	MESH:D009638	25516(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY NH2|nmod|release NH2|amod|END_ENTITY	Effects of nociceptinNH2 and -LSB- Nphe1 -RSB- nociceptin -LRB- 1-13 -RRB- NH2 on rat brain noradrenaline release in vivo and in vitro .
14757141	0	noradrenaline	46,59	nociceptin	32,42	noradrenaline	nociceptin	MESH:D009638	25516(Tax:10116)	Chemical	Gene	neurotransmission|amod|START_ENTITY END_ENTITY|nmod|neurotransmission	Tonic inhibition by orphanin_FQ / nociceptin of noradrenaline neurotransmission in the amygdala .
9879729	0	noradrenaline	51,64	nociceptin	37,47	noradrenaline	nociceptin	MESH:D009638	25516(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY END_ENTITY|nmod|release	ORL1 receptor-mediated inhibition by nociceptin of noradrenaline release from perivascular sympathetic nerve endings of the rat tail artery .
1355548	0	noradrenaline	81,94	platelet_activating_factor	11,37	noradrenaline	platelet activating factor	MESH:D009638	300795(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Effects Effects|nmod|END_ENTITY	Effects of platelet_activating_factor on contractions and 45Ca influx induced by noradrenaline and potassium in rat rubbed and intact aorta .
1346623	0	noradrenaline	21,34	renin	38,43	noradrenaline	renin	MESH:D009638	24715(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	A biphasic effect of noradrenaline on renin release from rat juxtaglomerular cells in vitro is mediated by alpha 1 - and beta-adrenoceptors .
6397510	0	noradrenaline	44,57	renin	122,127	noradrenaline	renin	MESH:D009638	403838(Tax:9615)	Chemical	Gene	concentrations|amod|START_ENTITY Effects|nmod|concentrations Effects|nmod|END_ENTITY	Effects of prolonged and brief infusions of noradrenaline on arterial pressure and on the plasma concentrations of active renin , angiotensin II , aldosterone and potassium .
7003179	0	noradrenaline	108,121	renin	123,128	noradrenaline	renin	MESH:D009638	403838(Tax:9615)	Chemical	Gene	START_ENTITY|appos|activity activity|compound|END_ENTITY	The effect of angiotensin II antagonist , Sar1-Ile8-angiotensin II , on furosemide-induced increase in plasma noradrenaline , renin activity and aldosterone in unanesthetized dogs .
1359611	0	noradrenaline	97,110	somatostatin	69,81	noradrenaline	somatostatin	MESH:D009638	494469(Tax:9823)	Chemical	Gene	relation|nmod|START_ENTITY END_ENTITY|nmod|relation	Vascular control of the pig nasal mucosa : distribution and effect of somatostatin in relation to noradrenaline and neuropeptide_Y .
15781025	0	noradrenaline	10,23	tumor_necrosis_factor-alpha	72,99	noradrenaline	tumor necrosis factor-alpha	MESH:D009638	7124	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|production production|amod|END_ENTITY	Effect of noradrenaline and isoproterenol on lipopolysaccharide-induced tumor_necrosis_factor-alpha production in whole blood from patients with chronic_heart_failure and the role of beta-adrenergic receptors .
6509570	0	noradrenaline	84,97	vasopressin	128,139	noradrenaline	vasopressin	MESH:D009638	551	Chemical	Gene	stimulation|amod|START_ENTITY administration|nmod|stimulation strips|nmod|administration strips|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Potentiation of the response of arterial strips to the exogenous administration of noradrenaline and transmural stimulation by vasopressin -RSB- .
6855454	0	noradrenaline	39,52	vasopressin	7,18	noradrenaline	vasopressin	MESH:D009638	551	Chemical	Gene	alter|dep|START_ENTITY fails|xcomp|alter fails|nsubj|END_ENTITY	Lysine vasopressin fails to alter -LRB- 3H -RRB- - noradrenaline uptake or release from hippocampal tissue in vitro .
24498990	0	noraristeromycin	24,40	IKKa	8,12	noraristeromycin	IKKa	MESH:C076829	12675(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	A novel IKKa inhibitor , noraristeromycin , blocks the chronic_inflammation associated with collagen-induced arthritis in mice .
15743210	0	norbinaltorphimine	42,60	kappa-opioid_receptor	76,97	norbinaltorphimine	kappa-opioid receptor	MESH:C051844	4986	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Major effect of pyrrolic_N-benzylation in norbinaltorphimine , the selective kappa-opioid_receptor antagonist .
1849995	0	norbinaltorphimine	98,116	kappa_opioid_receptor	33,54	norbinaltorphimine	kappa opioid receptor	MESH:C051844	4986	Chemical	Gene	related|xcomp|START_ENTITY related|nsubj|Role Role|nmod|spacer spacer|acl|conferring conferring|dobj|selectivity selectivity|compound|END_ENTITY	Role of the spacer in conferring kappa_opioid_receptor selectivity to bivalent ligands related to norbinaltorphimine .
22526543	0	norbinaltorphimine	49,67	kappa_opioid_receptor	15,36	norbinaltorphimine	kappa opioid receptor	MESH:C051844	18387(Tax:10090)	Chemical	Gene	Effects|amod|START_ENTITY Effects|nmod|END_ENTITY	Effects of the kappa_opioid_receptor antagonist , norbinaltorphimine , on stress and drug-induced reinstatement of nicotine-conditioned place preference in mice .
21889488	0	norbormide	144,154	translocator_protein	4,24	norbormide	translocator protein	MESH:C005321	24230(Tax:10116)	Chemical	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	The translocator_protein -LRB- peripheral benzodiazepine receptor -RRB- mediates rat-selective activation of the mitochondrial permeability transition by norbormide .
22363545	0	norcantharidin	26,40	MMP-9	102,107	norcantharidin	MMP-9	MESH:C069741	4318	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Antimetastatic effects of norcantharidin on hepatocellular_carcinoma by transcriptional inhibition of MMP-9 through modulation of NF-kB activity .
11321474	0	norcantharidin	10,24	N-acetyltransferase	28,47	norcantharidin	N-acetyltransferase	MESH:C069741	6046	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	Effect of norcantharidin on N-acetyltransferase activity in HepG2 cells .
18610748	0	nordihydroguaiaretic_acid	21,46	TA3	127,130	nordihydroguaiaretic acid	TA3	MESH:D009637	22027(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Inhibitory effect of nordihydroguaiaretic_acid and its tetra-acetylated derivative on respiration and growth of adenocarcinoma TA3 and its multiresistant variant TA3MTX-R .
10385691	0	nordihydroguaiaretic_acid	65,90	endothelial_nitric_oxide_synthase	28,61	nordihydroguaiaretic acid	endothelial nitric oxide synthase	MESH:D009637	4846	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|END_ENTITY	Modulation of expression of endothelial_nitric_oxide_synthase by nordihydroguaiaretic_acid , a phenolic antioxidant in cultured endothelial cells .
12359096	0	nordihydroguaiaretic_acid	10,35	lipoprotein_lipase	56,74	nordihydroguaiaretic acid	lipoprotein lipase	MESH:D009637	4023	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|nmod|END_ENTITY	Effect of nordihydroguaiaretic_acid on the secretion of lipoprotein_lipase .
23053656	0	nordihydroguaiaretic_acid	22,47	mTORC1	0,6	nordihydroguaiaretic acid	mTORC1	MESH:D009637	382056(Tax:10090)	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	mTORC1 is a target of nordihydroguaiaretic_acid to prevent breast_tumor growth in vitro and in vivo .
15379894	0	nordihydroguaiaretic_acid	46,71	tumor_necrosis_factor_alpha	81,108	nordihydroguaiaretic acid	tumor necrosis factor alpha	MESH:D009637	21926(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|compound|END_ENTITY	The arachidonic_acid 5-lipoxygenase inhibitor nordihydroguaiaretic_acid inhibits tumor_necrosis_factor_alpha activation of microglia and extends survival of G93A-SOD1 transgenic_mice .
12612453	0	norditerpenes	21,34	TNF-alpha	50,59	norditerpenes	TNF-alpha	MESH:D004224	21926(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Inhibitory effect of norditerpenes on LPS-induced TNF-alpha production from the Okinawan soft coral , Sinularia sp .
23662811	0	norditropin	28,39	Growth_hormone	0,14	norditropin	Growth hormone	MESH:D019382	2688	Chemical	Gene	therapy|nmod|START_ENTITY therapy|amod|END_ENTITY	Growth_hormone therapy with norditropin -LRB- somatropin -RRB- in growth_hormone deficiency .
7989494	0	norepinephrine	24,38	Angiotensin-II	0,14	norepinephrine	Angiotensin-II	MESH:D009638	183	Chemical	Gene	secretion|amod|START_ENTITY mediates|dobj|secretion mediates|nsubj|END_ENTITY	Angiotensin-II mediates norepinephrine and neuropeptide-Y secretion in a human pheochromocytoma .
2941312	0	norepinephrine	35,49	Atrial_natriuretic_factor	0,25	norepinephrine	Atrial natriuretic factor	MESH:D009638	24602(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY inhibits|dobj|release inhibits|nsubj|END_ENTITY	Atrial_natriuretic_factor inhibits norepinephrine release evoked by sympathetic nerve stimulation in isolated perfused rat mesenteric arteries .
2969821	0	norepinephrine	35,49	Atrial_natriuretic_factor	0,25	norepinephrine	Atrial natriuretic factor	MESH:D009638	24602(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY inhibits|dobj|release inhibits|nsubj|END_ENTITY	Atrial_natriuretic_factor inhibits norepinephrine release in an adrenergic clonal cell line -LRB- PC12 -RRB- .
3161659	0	norepinephrine	83,97	Atrial_natriuretic_factor	0,25	norepinephrine	Atrial natriuretic factor	MESH:D009638	24602(Tax:10116)	Chemical	Gene	infusion|nmod|START_ENTITY induced|nmod|infusion hypertension|acl|induced inhibits|dobj|hypertension inhibits|nsubj|END_ENTITY	Atrial_natriuretic_factor inhibits the hypertension induced by chronic infusion of norepinephrine in conscious rats .
6539299	0	norepinephrine	49,63	Atrial_natriuretic_factor	0,25	norepinephrine	Atrial natriuretic factor	MESH:D009638	24602(Tax:10116)	Chemical	Gene	inhibits|dep|START_ENTITY inhibits|nsubj|END_ENTITY	Atrial_natriuretic_factor inhibits angiotensin - , norepinephrine - , and potassium-induced vascular contractility .
8069683	0	norepinephrine	37,51	Atrial_natriuretic_factor	0,25	norepinephrine	Atrial natriuretic factor	MESH:D009638	24602(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|amod|END_ENTITY	Atrial_natriuretic_factor effects on norepinephrine uptake in discrete telencephalic and diencephalic nuclei of the rat .
8545048	0	norepinephrine	35,49	Atrial_natriuretic_factor	0,25	norepinephrine	Atrial natriuretic factor	MESH:D009638	24602(Tax:10116)	Chemical	Gene	solitarii|amod|START_ENTITY enhances|dobj|solitarii enhances|nsubj|END_ENTITY	Atrial_natriuretic_factor enhances norepinephrine uptake in circumventricular organs , locus coeruleus and nucleus tractus solitarii of the rat .
9299509	0	norepinephrine	68,82	Atrial_natriuretic_factor	0,25	norepinephrine	Atrial natriuretic factor	MESH:D009638	24602(Tax:10116)	Chemical	Gene	biosynthesis|nmod|START_ENTITY modifies|dobj|biosynthesis modifies|nsubj|END_ENTITY	Atrial_natriuretic_factor modifies the biosynthesis and turnover of norepinephrine in the rat adrenal medulla .
9792233	0	norepinephrine	42,56	Atrial_natriuretic_factor	0,25	norepinephrine	Atrial natriuretic factor	MESH:D009638	24602(Tax:10116)	Chemical	Gene	catabolism|amod|START_ENTITY affect|dobj|catabolism affect|nsubj|END_ENTITY	Atrial_natriuretic_factor does not affect norepinephrine catabolism in rat hypothalamus and adrenal medulla .
9288827	0	norepinephrine	40,54	Beta-endorphin	0,14	norepinephrine	Beta-endorphin	MESH:D009638	5443	Chemical	Gene	START_ENTITY|nsubj|inhibition inhibition|amod|END_ENTITY	Beta-endorphin inhibition of endogenous norepinephrine release from the A2 noradrenergic nucleus in vitro : role of mu opiate receptors and Na + ion permeability .
10027827	0	norepinephrine	29,43	Bradykinin	0,10	norepinephrine	Bradykinin	MESH:D009638	3827	Chemical	Gene	release|compound|START_ENTITY promotes|dobj|release promotes|nsubj|END_ENTITY	Bradykinin promotes ischemic norepinephrine release in guinea_pig and human hearts .
3167696	0	norepinephrine	13,27	CA1	47,50	norepinephrine	CA1	MESH:D009638	310218(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|region region|compound|END_ENTITY	Dual role of norepinephrine in the hippocampal CA1 region of the rat : inhibition and disinhibition .
7224914	0	norepinephrine	14,28	CSF	0,3	norepinephrine	CSF	MESH:D009638	1437	Chemical	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	CSF levels of norepinephrine during alcohol withdrawal .
21704393	0	norepinephrine	25,39	CTGF	76,80	norepinephrine	CTGF	MESH:D009638	64032(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|connective_tissue_growth_factor connective_tissue_growth_factor|appos|END_ENTITY	The regulatory effect of norepinephrine on connective_tissue_growth_factor -LRB- CTGF -RRB- and vascular endothelial growth factor -LRB- VEGF -RRB- expression in cultured cardiac fibroblasts .
21993205	0	norepinephrine	38,52	Corticotropin-releasing_factor	0,30	norepinephrine	Corticotropin-releasing factor	MESH:D009638	81648(Tax:10116)	Chemical	Gene	nucleus|amod|START_ENTITY END_ENTITY|nmod|nucleus	Corticotropin-releasing_factor in the norepinephrine nucleus , locus coeruleus , facilitates behavioral flexibility .
7882052	0	norepinephrine	115,129	Corticotropin-releasing_factor	0,30	norepinephrine	Corticotropin-releasing factor	MESH:D009638	1392	Chemical	Gene	release|amod|START_ENTITY stimulates|dobj|release stimulates|nsubj|coeruleus coeruleus|amod|END_ENTITY	Corticotropin-releasing_factor administered into the locus coeruleus , but not the parabrachial nucleus , stimulates norepinephrine release in the prefrontal cortex .
3991764	0	norepinephrine	113,127	Dopamine-beta-hydroxylase	0,25	norepinephrine	Dopamine-beta-hydroxylase	MESH:D009638	25699(Tax:10116)	Chemical	Gene	feeding|nmod|START_ENTITY reinstatement|nmod|feeding inhibitors|dep|reinstatement inhibitors|amod|END_ENTITY	Dopamine-beta-hydroxylase inhibitors , feeding and locomotor activity : reinstatement of feeding following central norepinephrine .
11914123	0	norepinephrine	50,64	ERK	28,31	norepinephrine	ERK	MESH:D009638	5594	Chemical	Gene	hepatocytes|nmod|START_ENTITY END_ENTITY|nmod|hepatocytes	Ca2 + - mediated activation of ERK in hepatocytes by norepinephrine and prostaglandin_F2_alpha : role of calmodulin and Src kinases .
9595417	0	norepinephrine	43,57	Endothelin-1	0,12	norepinephrine	Endothelin-1	MESH:D009638	24323(Tax:10116)	Chemical	Gene	enhances|xcomp|START_ENTITY enhances|nsubj|END_ENTITY	Endothelin-1 enhances pressor responses to norepinephrine : involvement of endothelin-B_receptor .
7474668	0	norepinephrine	51,65	Erythropoietin	0,14	norepinephrine	Erythropoietin	MESH:D009638	2056	Chemical	Gene	enhances|xcomp|START_ENTITY enhances|nsubj|END_ENTITY	Erythropoietin enhances vascular responsiveness to norepinephrine in renal_failure .
11123223	0	norepinephrine	39,53	FGF-2	88,93	norepinephrine	FGF-2	MESH:D009638	2247	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|role role|nmod|END_ENTITY	ANG II potentiates mitogenic effect of norepinephrine in vascular muscle cells : role of FGF-2 .
9539874	0	norepinephrine	11,25	IGF-1	43,48	norepinephrine	IGF-1	MESH:D009638	24482(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of norepinephrine on expression of IGF-1 / IGF-1R and SERCA2 in rat heart .
9539874	0	norepinephrine	11,25	IGF-1R	49,55	norepinephrine	IGF-1R	MESH:D009638	25718(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|dep|END_ENTITY	Effects of norepinephrine on expression of IGF-1 / IGF-1R and SERCA2 in rat heart .
9817439	0	norepinephrine	38,52	IL-1alpha	10,19	norepinephrine	IL-1alpha	MESH:D009638	24493(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY END_ENTITY|nmod|release	Effect of IL-1alpha on the release of norepinephrine in rat hypothalamus .
9728078	0	norepinephrine	19,33	IL-1beta	0,8	norepinephrine	IL-1beta	MESH:D009638	24494(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|increases increases|amod|END_ENTITY	IL-1beta increases norepinephrine level in rat frontal cortex : involvement of prostanoids , NO , and glutamate .
1735563	0	norepinephrine	38,52	Insulin	0,7	norepinephrine	Insulin	MESH:D009638	3630	Chemical	Gene	enhances|xcomp|START_ENTITY enhances|nsubj|END_ENTITY	Insulin enhances pressor responses to norepinephrine in rat mesenteric vasculature .
2673958	0	norepinephrine	20,34	Insulin	0,7	norepinephrine	Insulin	MESH:D009638	100009181(Tax:9986)	Chemical	Gene	blockade|nmod|START_ENTITY blockade|compound|END_ENTITY	Insulin blockade of norepinephrine tachyphylaxis in the perfused kidney .
23000030	0	norepinephrine	89,103	Interleukin-1_beta	0,18	norepinephrine	Interleukin-1 beta	MESH:D009638	24494(Tax:10116)	Chemical	Gene	levels|amod|START_ENTITY modulating|dobj|levels affects|advcl|modulating affects|nsubj|END_ENTITY	Interleukin-1_beta simultaneously affects the stress and reproductive axes by modulating norepinephrine levels in different brain areas .
8393485	0	norepinephrine	39,53	Interleukin-1_beta	0,18	norepinephrine	Interleukin-1 beta	MESH:D009638	24494(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY release|amod|END_ENTITY	Interleukin-1_beta augments release of norepinephrine , dopamine , and serotonin in the rat anterior hypothalamus .
8430802	0	norepinephrine	33,47	Interleukin-1_beta	0,18	norepinephrine	Interleukin-1 beta	MESH:D009638	24494(Tax:10116)	Chemical	Gene	modulation|nmod|START_ENTITY modulation|amod|END_ENTITY	Interleukin-1_beta modulation of norepinephrine release from rat myenteric nerves .
15833600	0	norepinephrine	66,80	Interleukin-1beta	9,26	norepinephrine	Interleukin-1beta	MESH:D009638	24494(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Systemic Interleukin-1beta stimulates the simultaneous release of norepinephrine in the paraventricular nucleus and the median eminence .
8392517	0	norepinephrine	74,88	Interleukin-6	0,13	norepinephrine	Interleukin-6	MESH:D009638	24498(Tax:10116)	Chemical	Gene	induction|nmod|START_ENTITY production|dep|induction production|amod|END_ENTITY	Interleukin-6 production by astrocytes : induction by the neurotransmitter norepinephrine .
10395017	0	norepinephrine	16,30	Leptin	0,6	norepinephrine	Leptin	MESH:D009638	25608(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY inhibits|dobj|release inhibits|nsubj|END_ENTITY	Leptin inhibits norepinephrine and dopamine release from rat hypothalamic neuronal endings .
7905857	0	norepinephrine	18,32	NET1	54,58	norepinephrine	NET1	MESH:D009638	10276	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Assignment of the norepinephrine transporter protein -LRB- NET1 -RRB- locus to chromosome 16 .
10959006	0	norepinephrine	39,53	Neuropeptide_Y	0,14	norepinephrine	Neuropeptide Y	MESH:D009638	100724008	Chemical	Gene	cotransmitter|nmod|START_ENTITY cotransmitter|nsubj|END_ENTITY	Neuropeptide_Y is a cotransmitter with norepinephrine in guinea_pig inferior mesenteric vein .
11080198	0	norepinephrine	35,49	Neuropeptide_Y	0,14	norepinephrine	Neuropeptide Y	MESH:D009638	4852	Chemical	Gene	cotransmission|nmod|START_ENTITY cotransmission|amod|END_ENTITY	Neuropeptide_Y cotransmission with norepinephrine in the sympathetic nerve-macrophage interplay .
11922898	0	norepinephrine	89,103	Neuropeptide_Y	0,14	norepinephrine	Neuropeptide Y	MESH:D009638	24604(Tax:10116)	Chemical	Gene	modifies|xcomp|START_ENTITY modifies|nsubj|END_ENTITY	Neuropeptide_Y modifies the hypertrophic response of adult ventricular cardiomyocytes to norepinephrine .
2472359	0	norepinephrine	30,44	Neuropeptide_Y	0,14	norepinephrine	Neuropeptide Y	MESH:D009638	24604(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY END_ENTITY|nmod|release	Neuropeptide_Y and galanin in norepinephrine release in hypothalamic slices .
25914972	0	norepinephrine	45,59	Neuropeptide_Y	0,14	norepinephrine	Neuropeptide Y	MESH:D009638	397304(Tax:9823)	Chemical	Gene	modulator|nmod|START_ENTITY END_ENTITY|nmod|modulator	Neuropeptide_Y as a presynaptic modulator of norepinephrine release from the sympathetic nerve fibers in the pig pineal gland .
25914972	0	norepinephrine	45,59	Neuropeptide_Y	0,14	norepinephrine	Neuropeptide Y	MESH:D009638	397304(Tax:9823)	Chemical	Gene	modulator|nmod|START_ENTITY END_ENTITY|nmod|modulator	Neuropeptide_Y as a presynaptic modulator of norepinephrine release from the sympathetic nerve fibers in the pig pineal gland .
25928910	0	norepinephrine	45,59	Neuropeptide_Y	0,14	norepinephrine	Neuropeptide Y	MESH:D009638	397304(Tax:9823)	Chemical	Gene	modulator|nmod|START_ENTITY END_ENTITY|nmod|modulator	Neuropeptide_Y as a presynaptic modulator of norepinephrine release from the sympathetic nerve fibers in the pig pineal gland .
12170059	0	norepinephrine	54,68	Nicotinic_acetylcholine_receptor	0,32	norepinephrine	Nicotinic acetylcholine receptor	MESH:D009638	170945(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Nicotinic_acetylcholine_receptor regulation of spinal norepinephrine release .
11551920	0	norepinephrine	20,34	Smad7	0,5	norepinephrine	Smad7	MESH:D009638	81516(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Smad7 is induced by norepinephrine and protects rat hepatocytes from activin_A-induced growth inhibition .
6790402	0	norepinephrine	47,61	Thyrotropin-releasing_hormone	0,29	norepinephrine	Thyrotropin-releasing hormone	MESH:D009638	7200	Chemical	Gene	increases|dobj|START_ENTITY increases|nsubj|END_ENTITY	Thyrotropin-releasing_hormone increases plasma norepinephrine in man .
17981009	0	norepinephrine	75,89	VEGF	0,4	norepinephrine	VEGF	MESH:D009638	7422	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	VEGF is differentially regulated in multiple_myeloma-derived cell lines by norepinephrine .
18396760	0	norepinephrine	78,92	VEGF	33,37	norepinephrine	VEGF	MESH:D009638	83785(Tax:10116)	Chemical	Gene	-LSB-|nmod|START_ENTITY -LSB-|nmod|expression expression|amod|END_ENTITY	-LSB- The influence of terbutaline on VEGF gene expression in rat astrocytes after norepinephrine and burn serum induction -RSB- .
21704393	0	norepinephrine	25,39	VEGF	122,126	norepinephrine	VEGF	MESH:D009638	83785(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|connective_tissue_growth_factor connective_tissue_growth_factor|appos|END_ENTITY	The regulatory effect of norepinephrine on connective_tissue_growth_factor -LRB- CTGF -RRB- and vascular endothelial growth factor -LRB- VEGF -RRB- expression in cultured cardiac fibroblasts .
3866254	0	norepinephrine	60,74	Vasoactive_intestinal_polypeptide	0,33	norepinephrine	Vasoactive intestinal polypeptide	MESH:D009638	117064(Tax:10116)	Chemical	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	Vasoactive_intestinal_polypeptide acts synergistically with norepinephrine to depress spontaneous discharge rate in cerebral cortical neurons .
10667533	0	norepinephrine	33,47	Vasopressin	0,11	norepinephrine	Vasopressin	MESH:D009638	551	Chemical	Gene	alternative|acl|START_ENTITY END_ENTITY|nmod|alternative	Vasopressin as an alternative to norepinephrine in the treatment of milrinone-induced hypotension .
18265860	0	norepinephrine	27,41	Vasopressin	0,11	norepinephrine	Vasopressin	MESH:D009638	551	Chemical	Gene	added|xcomp|START_ENTITY END_ENTITY|acl:relcl|added	Vasopressin , when added to norepinephrine , was not associated with increased predicted mortality after cardiac surgery .
18305265	0	norepinephrine	19,33	Vasopressin	0,11	norepinephrine	Vasopressin	MESH:D009638	551	Chemical	Gene	START_ENTITY|nsubj|versus versus|compound|END_ENTITY	Vasopressin versus norepinephrine infusion in patients with septic_shock .
15869489	0	norepinephrine	11,25	ZENK	65,69	norepinephrine	ZENK	MESH:D009638	100008579(Tax:59729)	Chemical	Gene	role|nmod|START_ENTITY END_ENTITY|nsubj|role	A role for norepinephrine in the regulation of context-dependent ZENK expression in male zebra finches -LRB- Taeniopygia_guttata -RRB- .
9241547	0	norepinephrine	53,67	alpha-1	14,21	norepinephrine	alpha-1	MESH:D009638	146	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|blocker blocker|amod|END_ENTITY	Effect of the alpha-1 adrenoceptor blocker on tissue norepinephrine contents in human benign_prostatic_hyperplasia .
12817186	0	norepinephrine	9,23	angiotensin-converting_enzyme	49,78	norepinephrine	angiotensin-converting enzyme	MESH:D009638	1636	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|amod|END_ENTITY	Regional norepinephrine spillover in response to angiotensin-converting_enzyme inhibition in healthy subjects .
1648463	0	norepinephrine	60,74	angiotensin-converting_enzyme	10,39	norepinephrine	angiotensin-converting enzyme	MESH:D009638	100009274(Tax:9986)	Chemical	Gene	rate|compound|START_ENTITY Effect|nmod|rate Effect|nmod|inhibition inhibition|amod|END_ENTITY	Effect of angiotensin-converting_enzyme inhibition on renal norepinephrine spillover rate and baroreflex responses in conscious rabbits .
1423026	0	norepinephrine	61,75	angiotensin_II	35,49	norepinephrine	angiotensin II	MESH:D009638	24179(Tax:10116)	Chemical	Gene	uptake|amod|START_ENTITY effects|nmod|uptake effects|nmod|END_ENTITY	Monophasic and biphasic effects of angiotensin_II and III on norepinephrine uptake and release in rat adrenal medulla .
2046466	0	norepinephrine	50,64	angiotensin_II	11,25	norepinephrine	angiotensin II	MESH:D009638	183	Chemical	Gene	Effects|acl|START_ENTITY Effects|nmod|END_ENTITY	Effects of angiotensin_II on pressor responses to norepinephrine in humans .
8593828	0	norepinephrine	14,28	angiotensin_II	49,63	norepinephrine	angiotensin II	MESH:D009638	24179(Tax:10116)	Chemical	Gene	system|amod|START_ENTITY system|nmod|END_ENTITY	Regulation of norepinephrine transport system by angiotensin_II in neuronal cultures of normotensive and spontaneously hypertensive rat brains .
1438987	0	norepinephrine	40,54	atrial_natriuretic_factor	11,36	norepinephrine	atrial natriuretic factor	MESH:D009638	24602(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY END_ENTITY|nmod|release	Effects of atrial_natriuretic_factor on norepinephrine release in the rat hypothalamus .
2142423	0	norepinephrine	22,36	atrial_natriuretic_factor	48,73	norepinephrine	atrial natriuretic factor	MESH:D009638	4878	Chemical	Gene	Correlation|nmod|START_ENTITY END_ENTITY|nsubj|Correlation	Correlation of plasma norepinephrine and plasma atrial_natriuretic_factor during lower body negative pressure .
8342501	0	norepinephrine	54,68	atrial_natriuretic_factor	27,52	norepinephrine	atrial natriuretic factor	MESH:D009638	4878	Chemical	Gene	START_ENTITY|nsubj|value value|nmod|END_ENTITY	Prognostic value of plasma atrial_natriuretic_factor , norepinephrine and epinephrine in acute_myocardial_infarction .
8574778	0	norepinephrine	40,54	atrial_natriuretic_factor	11,36	norepinephrine	atrial natriuretic factor	MESH:D009638	24602(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY END_ENTITY|nmod|release	Effects of atrial_natriuretic_factor on norepinephrine release evoked by angiotensins II and III in the rat adrenal medulla .
1301634	0	norepinephrine	65,79	atrial_natriuretic_peptide	11,37	norepinephrine	atrial natriuretic peptide	MESH:D009638	24602(Tax:10116)	Chemical	Gene	uptake|amod|START_ENTITY Effects|nmod|uptake Effects|nmod|END_ENTITY	Effects of atrial_natriuretic_peptide , angiotensin_II and III on norepinephrine uptake in the rat adrenal medulla .
1377629	0	norepinephrine	27,41	atrial_natriuretic_peptide	53,79	norepinephrine	atrial natriuretic peptide	MESH:D009638	24602(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY release|nmod|END_ENTITY	Modulation of hypothalamic norepinephrine release by atrial_natriuretic_peptide : involvement of cyclic_GMP .
12239109	0	norepinephrine	50,64	cFos	42,46	norepinephrine	cFos	MESH:D009638	314322(Tax:10116)	Chemical	Gene	neurons|amod|START_ENTITY END_ENTITY|nmod|neurons	Expression of estrogen receptor-alpha and cFos in norepinephrine and epinephrine neurons of young and middle-aged rats during the steroid-induced luteinizing hormone surge .
8138937	0	norepinephrine	24,38	catechol-O-methyltransferase	58,86	norepinephrine	catechol-O-methyltransferase	MESH:D009638	24267(Tax:10116)	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|nmod|END_ENTITY	Different metabolism of norepinephrine and epinephrine by catechol-O-methyltransferase and monoamine_oxidase in rats .
2577226	0	norepinephrine	58,72	cholecystokinin	19,34	norepinephrine	cholecystokinin	MESH:D009638	25298(Tax:10116)	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	The interaction of cholecystokinin and its fragments with norepinephrine in the circulatory system of diabetic rats .
10560022	0	norepinephrine	44,58	corticotropin-releasing_factor	12,42	norepinephrine	corticotropin-releasing factor	MESH:D009638	81648(Tax:10116)	Chemical	Gene	systems|amod|START_ENTITY role|dep|systems role|nmod|END_ENTITY	The role of corticotropin-releasing_factor -- norepinephrine systems in mediating the effects of early experience on the development of behavioral and endocrine responses to stress .
14598308	0	norepinephrine	23,37	corticotropin-releasing_factor	71,101	norepinephrine	corticotropin-releasing factor	MESH:D009638	1392	Chemical	Gene	modifies|nsubj|START_ENTITY modifies|dobj|behavior behavior|acl|induced induced|nmod|END_ENTITY	Centrally administered norepinephrine modifies the behavior induced by corticotropin-releasing_factor in neonatal chicks .
15385601	0	norepinephrine	38,52	corticotropin-releasing_factor	63,93	norepinephrine	corticotropin-releasing factor	MESH:D009638	81648(Tax:10116)	Chemical	Gene	system|compound|START_ENTITY sensitizes|dobj|system sensitizes|nmod|END_ENTITY	Chronic morphine sensitizes the brain norepinephrine system to corticotropin-releasing_factor and stress .
22210331	0	norepinephrine	121,135	corticotropin-releasing_factor	24,54	norepinephrine	corticotropin-releasing factor	MESH:D009638	81648(Tax:10116)	Chemical	Gene	neurons|compound|START_ENTITY mode|nmod|neurons alter|dobj|mode engages|advcl|alter engages|dobj|systems systems|amod|END_ENTITY	Predator stress engages corticotropin-releasing_factor and opioid systems to alter the operating mode of locus coeruleus norepinephrine neurons .
22508464	0	norepinephrine	37,51	corticotropin-releasing_factor	73,103	norepinephrine	corticotropin-releasing factor	MESH:D009638	12918(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|overexpression overexpression|amod|END_ENTITY	Increased vulnerability of the brain norepinephrine system of females to corticotropin-releasing_factor overexpression .
7956940	0	norepinephrine	18,32	corticotropin-releasing_factor	97,127	norepinephrine	corticotropin-releasing factor	MESH:D009638	81648(Tax:10116)	Chemical	Gene	Microinjection|nmod|START_ENTITY stimulates|nsubj|Microinjection stimulates|dobj|expression expression|amod|END_ENTITY	Microinjection of norepinephrine into the paraventricular nucleus of the hypothalamus stimulates corticotropin-releasing_factor gene expression in conscious rats .
10377355	0	norepinephrine	117,131	corticotropin-releasing_hormone	27,58	norepinephrine	corticotropin-releasing hormone	MESH:D009638	81648(Tax:10116)	Chemical	Gene	transcription|nmod|START_ENTITY transcription|nsubj|regulation regulation|nmod|gene gene|compound|END_ENTITY	Differential regulation of corticotropin-releasing_hormone and vasopressin gene transcription in the hypothalamus by norepinephrine .
201940	0	norepinephrine	64,78	dopamine-beta-hydroxylase	17,42	norepinephrine	dopamine-beta-hydroxylase	MESH:D009638	25699(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Possible role of dopamine-beta-hydroxylase in the regulation of norepinephrine biosynthesis in rat brain .
4913714	0	norepinephrine	42,56	dopamine-beta-hydroxylase	11,36	norepinephrine	dopamine-beta-hydroxylase	MESH:D009638	1621	Chemical	Gene	stimulation|amod|START_ENTITY Release|nmod|stimulation Release|nmod|END_ENTITY	Release of dopamine-beta-hydroxylase with norepinephrine during cat splenic nerve stimulation .
6851028	0	norepinephrine	7,21	dopamine-beta-hydroxylase	47,72	norepinephrine	dopamine-beta-hydroxylase	MESH:D009638	1621	Chemical	Gene	START_ENTITY|dobj|activity activity|amod|END_ENTITY	Plasma norepinephrine concentration and plasma dopamine-beta-hydroxylase activity in patients with congestive_heart_failure .
11206730	0	norepinephrine	89,103	endothelin-1	31,43	norepinephrine	endothelin-1	MESH:D009638	403424(Tax:9615)	Chemical	Gene	response|nmod|START_ENTITY response|nmod|END_ENTITY	Biphasic inotropic response to endothelin-1 in the presence of various concentrations of norepinephrine in dog ventricular myocardium .
15764840	0	norepinephrine	118,132	endothelin-1	82,94	norepinephrine	endothelin-1	MESH:D009638	1906	Chemical	Gene	induced|nmod|START_ENTITY induced|advcl|END_ENTITY	Receptor subtypes mediating the inotropic effects and Ca -LRB- 2 + -RRB- signaling induced by endothelin-1 through crosstalk with norepinephrine in canine ventricular myocardium .
2194695	0	norepinephrine	68,82	endothelin-1	28,40	norepinephrine	endothelin-1	MESH:D009638	1906	Chemical	Gene	concentrations|nmod|START_ENTITY concentrations|nmod|contractions contractions|amod|END_ENTITY	Threshold concentrations of endothelin-1 potentiate contractions to norepinephrine and serotonin in human arteries .
2473286	0	norepinephrine	126,140	endothelin-1	21,33	norepinephrine	endothelin-1	MESH:D009638	1906	Chemical	Gene	comparison|nmod|START_ENTITY effects|dep|comparison effects|nmod|relaxation relaxation|amod|END_ENTITY	Different effects of endothelin-1 on cAMP - and cGMP-mediated vascular relaxation in human arteries and veins : comparison with norepinephrine .
16869081	0	norepinephrine	39,53	endothelin_1	23,35	norepinephrine	endothelin 1	MESH:D009638	100726197	Chemical	Gene	release|amod|START_ENTITY END_ENTITY|nmod|release	-LSB- Effects of endogenous endothelin_1 on norepinephrine release and arrhythmia in cardiac_ischemia and reperfusion -- a study by Langendorff perfusion system using the heart excised from a guinea_pig -RSB- .
7539818	0	norepinephrine	29,43	galanin	6,13	norepinephrine	galanin	MESH:D009638	51083	Chemical	Gene	levels|compound|START_ENTITY reduces|dobj|levels reduces|nsubj|END_ENTITY	Human galanin reduces plasma norepinephrine levels in man .
15500541	0	norepinephrine	20,34	gonadotropin-releasing_hormone	85,115	norepinephrine	gonadotropin-releasing hormone	MESH:D009638	25194(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|stimulation stimulation|nmod|release release|amod|END_ENTITY	Interaction between norepinephrine , oxytocin , and nitric_oxide in the stimulation of gonadotropin-releasing_hormone release from proestrous rat basal hypothalamus explants .
2882402	0	norepinephrine	21,35	immunoreactive_corticotropin-releasing_factor	39,84	norepinephrine	immunoreactive corticotropin-releasing factor	MESH:D009638	24714(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|release release|amod|END_ENTITY	Inhibitory effect of norepinephrine on immunoreactive_corticotropin-releasing_factor release from the rat hypothalamus in vitro .
11600560	0	norepinephrine	113,127	insulin	16,23	norepinephrine	insulin	MESH:D009638	3630	Chemical	Gene	concentration|compound|START_ENTITY decrease|nmod|concentration associated|nmod|decrease associated|nsubjpass|hypersecretion hypersecretion|compound|END_ENTITY	Glucose-induced insulin hypersecretion in lipid-infused healthy subjects is associated with a decrease in plasma norepinephrine concentration and urinary excretion .
17012525	0	norepinephrine	20,34	insulin	55,62	norepinephrine	insulin	MESH:D009638	3630	Chemical	Gene	START_ENTITY|xcomp|interact interact|xcomp|predict predict|dobj|resistance resistance|compound|END_ENTITY	Hostility and urine norepinephrine interact to predict insulin resistance : the VA Normative Aging Study .
24358443	0	norepinephrine	16,30	insulin	40,47	norepinephrine	insulin	MESH:D009638	3630	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|compound|END_ENTITY	Elevated plasma norepinephrine inhibits insulin secretion , but adrenergic blockade reveals enhanced b-cell responsiveness in an ovine model of placental_insufficiency at 0.7 of gestation .
2498609	0	norepinephrine	28,42	insulin	10,17	norepinephrine	insulin	MESH:D009638	3630	Chemical	Gene	plasma|amod|START_ENTITY Effect|nmod|plasma Effect|nmod|END_ENTITY	Effect of insulin on plasma norepinephrine and 3,4-dihydroxyphenylalanine in obese men .
5327883	0	norepinephrine	33,47	insulin	14,21	norepinephrine	insulin	MESH:D009638	3630	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of insulin release by norepinephrine in man .
6998806	0	norepinephrine	37,51	insulin	93,100	norepinephrine	insulin	MESH:D009638	101823595	Chemical	Gene	concentration|compound|START_ENTITY islet|dobj|concentration islet|nmod|secretion secretion|compound|END_ENTITY	Effect of increased pancreatic islet norepinephrine , dopamine and serotonin concentration on insulin secretion in the golden_hamster .
7702805	0	norepinephrine	54,68	insulin	10,17	norepinephrine	insulin	MESH:D009638	3630	Chemical	Gene	response|acl|START_ENTITY END_ENTITY|nmod|response	Effect of insulin on the venoconstrictive response to norepinephrine in normal human subjects : the influence of sodium status .
7704288	0	norepinephrine	67,81	insulin	121,128	norepinephrine	insulin	MESH:D009638	3630	Chemical	Gene	spillover|amod|START_ENTITY effect|appos|spillover effect|appos|END_ENTITY	The effect of metformin and insulin on sympathetic nerve activity , norepinephrine spillover and blood pressure in obese , insulin resistant , normoglycemic , hypertensive men .
8206583	0	norepinephrine	22,36	insulin	57,64	norepinephrine	insulin	MESH:D009638	3630	Chemical	Gene	Vasoconstriction|nmod|START_ENTITY causes|nsubj|Vasoconstriction causes|dobj|resistance resistance|compound|END_ENTITY	Vasoconstriction with norepinephrine causes less forearm insulin resistance than a reflex sympathetic vasoconstriction .
12183018	0	norepinephrine	88,102	interleukin-1_beta	11,29	norepinephrine	interleukin-1 beta	MESH:D009638	24494(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY Effects|dep|role Effects|nmod|surge surge|amod|END_ENTITY	Effects of interleukin-1_beta on the steroid-induced luteinizing hormone surge : role of norepinephrine in the medial preoptic area .
8384045	0	norepinephrine	55,69	interleukin-1_beta	26,44	norepinephrine	interleukin-1 beta	MESH:D009638	24494(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|administration administration|nmod|increases increases|amod|END_ENTITY	Central administration of interleukin-1_beta increases norepinephrine turnover in the spleen .
10098870	0	norepinephrine	51,65	interleukin-6	108,121	norepinephrine	interleukin-6	MESH:D009638	16193(Tax:10090)	Chemical	Gene	involvement|nmod|START_ENTITY involvement|nmod|responses responses|amod|END_ENTITY	Differential involvement of central and peripheral norepinephrine in the central lipopolysaccharide-induced interleukin-6 responses in mice .
24519125	0	norepinephrine	23,37	interleukin-6	46,59	norepinephrine	interleukin-6	MESH:D009638	3569	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Stress-related hormone norepinephrine induces interleukin-6 expression in GES-1 cells .
9878889	0	norepinephrine	100,114	monoamine_oxidase_A	66,85	norepinephrine	monoamine oxidase A	MESH:D009638	4128	Chemical	Gene	metabolite|nmod|START_ENTITY metabolite|compound|END_ENTITY	Accumulation of 3,4-dihydroxyphenylglycolaldehyde , the neurotoxic monoamine_oxidase_A metabolite of norepinephrine , in locus ceruleus cell bodies in Alzheimer 's _ disease : mechanism of neuron_death .
8930697	0	norepinephrine	42,56	nerve_growth_factor	11,30	norepinephrine	nerve growth factor	MESH:D009638	310738(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of nerve_growth_factor on splenic norepinephrine and pineal N-acetyl-transferase in neonate rats exposed to alcohol in utero : neuroimmune correlates .
2169424	0	norepinephrine	29,43	neuropeptide_Y	11,25	norepinephrine	neuropeptide Y	MESH:D009638	24604(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY Effects|nmod|release Effects|nmod|END_ENTITY	Effects of neuropeptide_Y on norepinephrine release in hypothalamic slices of spontaneously hypertensive rats .
2477116	0	norepinephrine	29,43	neuropeptide_Y	11,25	norepinephrine	neuropeptide Y	MESH:D009638	24604(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	Effects of neuropeptide_Y on norepinephrine and serotonin metabolism in rat hypothalamus in vivo .
2668503	0	norepinephrine	71,85	neuropeptide_Y	11,25	norepinephrine	neuropeptide Y	MESH:D009638	100301542(Tax:9986)	Chemical	Gene	stimulation|amod|START_ENTITY vessels|nmod|stimulation response|nmod|vessels END_ENTITY|nmod|response	Effects of neuropeptide_Y on the response of isolated blood vessels to norepinephrine and sympathetic field stimulation .
8402398	0	norepinephrine	8,22	neuropeptide_Y	24,38	norepinephrine	neuropeptide Y	MESH:D009638	24604(Tax:10116)	Chemical	Gene	Lack|nmod|START_ENTITY Lack|dep|interactions interactions|amod|END_ENTITY	Lack of norepinephrine -- neuropeptide_Y interactions in the hypothalamic control of cardiovascular regulation in urethane-anesthetized rats .
8483814	0	norepinephrine	106,120	neuropeptide_Y	66,80	norepinephrine	neuropeptide Y	MESH:D009638	100301542(Tax:9986)	Chemical	Gene	coronary|nmod|START_ENTITY coronary|nmod|END_ENTITY	Effects of age and hyperlipidemia on rabbit coronary responses to neuropeptide_Y and the interaction with norepinephrine .
8780041	0	norepinephrine	84,98	neuropeptide_Y	11,25	norepinephrine	neuropeptide Y	MESH:D009638	24604(Tax:10116)	Chemical	Gene	content|compound|START_ENTITY influencing|dobj|content drugs|acl|influencing RNA|nmod|drugs RNA|nsubj|Changes Changes|nmod|messenger messenger|amod|END_ENTITY	Changes of neuropeptide_Y messenger RNA and peptide by drugs influencing endogenous norepinephrine content in cerebrocortex of the rat .
3742254	0	norepinephrine	53,67	neurotensin	11,22	norepinephrine	neurotensin	MESH:D009638	299757(Tax:10116)	Chemical	Gene	concentrations|nmod|START_ENTITY Effects|nmod|concentrations Effects|nmod|END_ENTITY	Effects of neurotensin on regional concentrations of norepinephrine in rat brain .
8343229	0	norepinephrine	26,40	neurotensin	11,22	norepinephrine	neurotensin	MESH:D009638	299757(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY Effects|nmod|release Effects|nmod|END_ENTITY	Effects of neurotensin on norepinephrine release in blood vessels of spontaneously hypertensive rats .
21646052	0	norepinephrine	8,22	p75NTR	59,65	norepinephrine	p75NTR	MESH:D009638	18053(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Altered norepinephrine content and ventricular function in p75NTR - / - mice after myocardial_infarction .
4059661	0	norepinephrine	86,100	phenylethanolamine_N-methyltransferase	11,49	norepinephrine	phenylethanolamine N-methyltransferase	MESH:D009638	24661(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|inhibitors inhibitors|amod|END_ENTITY	Effects of phenylethanolamine_N-methyltransferase inhibitors on uptake and release of norepinephrine and dopamine from rat brain .
15531715	1	norepinephrine	195,209	prolactin	120,129	norepinephrine	prolactin	MESH:D009638	5617	Chemical	Gene	deiodinase|xcomp|START_ENTITY type|acl:relcl|deiodinase down-regulates|dobj|type down-regulates|nsubj|pulse pulse|compound|END_ENTITY	The prolactin pulse down-regulates mammary type I deiodinase responsiveness to norepinephrine .
16159376	0	norepinephrine	16,30	prolactin	54,63	norepinephrine	prolactin	MESH:D009638	24683(Tax:10116)	Chemical	Gene	regulates|advmod|START_ENTITY regulates|dobj|surge surge|nmod|END_ENTITY	Locus coeruleus norepinephrine regulates the surge of prolactin during oestrus .
198064	0	norepinephrine	8,22	prolactin	41,50	norepinephrine	prolactin	MESH:D009638	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	Role of norepinephrine in the release of prolactin induced by suckling and estrogen .
3613861	0	norepinephrine	88,102	prolactin	15,24	norepinephrine	prolactin	MESH:D009638	24683(Tax:10116)	Chemical	Gene	dihydroxyphenyl-serine|nmod|START_ENTITY Stimulation|dep|dihydroxyphenyl-serine Stimulation|nmod|secretion secretion|compound|END_ENTITY	Stimulation of prolactin secretion by L-3 ,4 - dihydroxyphenyl-serine -LRB- L-DOPS -RRB- via central norepinephrine in the rat .
5818077	0	norepinephrine	13,27	prolactin	95,104	norepinephrine	prolactin	MESH:D009638	5617	Chemical	Gene	agents|amod|START_ENTITY Influence|nmod|agents Influence|nmod|synthesis synthesis|nmod|END_ENTITY	Influence of norepinephrine and catecholamine-depleting agents on the synthesis and release of prolactin and growth_hormone .
1096294	0	norepinephrine	22,36	renin	44,49	norepinephrine	renin	MESH:D009638	403838(Tax:9615)	Chemical	Gene	circulating|dobj|START_ENTITY circulating|nmod|END_ENTITY	Effect of circulating norepinephrine on the renin release from the denervated kidney .
12130713	0	norepinephrine	156,170	renin	18,23	norepinephrine	renin	MESH:D009638	5972	Chemical	Gene	release|compound|START_ENTITY contribution|nmod|release heart|dep|contribution isolated|nmod|heart terminals|acl|isolated activation|nmod|terminals activation|compound|END_ENTITY	Ischemia promotes renin activation and angiotensin formation in sympathetic nerve terminals isolated from the human heart : contribution to carrier-mediated norepinephrine release .
215928	0	norepinephrine	10,24	renin	28,33	norepinephrine	renin	MESH:D009638	24715(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	Effect of norepinephrine on renin release and the cyclic_AMP content of rat kidney slices : modification by sodium deficiency and alpha-adrenergic blockade .
2679151	0	norepinephrine	32,46	renin	50,55	norepinephrine	renin	MESH:D009638	443310(Tax:9940)	Chemical	Gene	released|dobj|START_ENTITY released|nmod|secretion secretion|compound|END_ENTITY	Ontogeny of neuronally released norepinephrine on renin secretion in sheep .
2974684	0	norepinephrine	66,80	renin	106,111	norepinephrine	renin	MESH:D009638	5972	Chemical	Gene	START_ENTITY|dobj|activity activity|compound|END_ENTITY	Atrial natriuretic factor , digoxin-like immunoreactive substance , norepinephrine , epinephrine , and plasma renin activity in human fetuses and their alteration by fetal disease .
2989497	0	norepinephrine	22,36	renin	71,76	norepinephrine	renin	MESH:D009638	24715(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|release release|compound|END_ENTITY	Inhibitory effects of norepinephrine , methoxamine and phenylephrine on renin release from rat kidney cortical slices .
3319038	0	norepinephrine	37,51	renin	74,79	norepinephrine	renin	MESH:D009638	24715(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY concentration|appos|activity activity|compound|END_ENTITY	Parabrachial_lesions increase plasma norepinephrine concentration , plasma renin activity and enhance baroreflex sensitivity in the conscious rat .
3525199	0	norepinephrine	59,73	renin	77,82	norepinephrine	renin	MESH:D009638	24715(Tax:10116)	Chemical	Gene	released|dobj|START_ENTITY released|nmod|release release|compound|END_ENTITY	The different effects of exogenous and neuronally released norepinephrine on renin release in rat kidney cortical slices .
3895792	0	norepinephrine	73,87	renin	127,132	norepinephrine	renin	MESH:D009638	5972	Chemical	Gene	Relationships|appos|START_ENTITY Relationships|appos|activity activity|compound|END_ENTITY	Relationships between blood pressure , heart rate and plasma epinephrine , norepinephrine , angiotensin_II concentrations , plasma renin activity during chronic guanfacine therapy in patients with essential arterial hypertension .
4304350	0	norepinephrine	57,71	renin	24,29	norepinephrine	renin	MESH:D009638	5972	Chemical	Gene	START_ENTITY|advcl|vitro vitro|dobj|stimulation stimulation|nmod|production production|compound|END_ENTITY	In vitro stimulation of renin production by epinephrine , norepinephrine , and cyclic_AMP .
4413101	0	norepinephrine	78,92	renin	60,65	norepinephrine	renin	MESH:D009638	5972	Chemical	Gene	blocking|advcl|START_ENTITY blocking|nmod|response response|compound|END_ENTITY	Effect of theophylline and adrenergic blocking drugs on the renin response to norepinephrine in vitro .
6186863	0	norepinephrine	33,47	renin	71,76	norepinephrine	renin	MESH:D009638	24715(Tax:10116)	Chemical	Gene	circulating|dobj|START_ENTITY circulating|nmod|secretion secretion|compound|END_ENTITY	Inhibitory effect of circulating norepinephrine on epinephrine-induced renin secretion .
6258839	0	norepinephrine	51,65	renin	7,12	norepinephrine	renin	MESH:D009638	5972	Chemical	Gene	concentrations|nmod|START_ENTITY END_ENTITY|dobj|concentrations	Plasma renin activity and plasma concentrations of norepinephrine and cyclic_nucleotides in heart_failure after prazosin .
668387	0	norepinephrine	56,70	renin	7,12	norepinephrine	renin	MESH:D009638	403838(Tax:9615)	Chemical	Gene	infusion|amod|START_ENTITY induced|nmod|infusion induced|nsubj|activity activity|compound|END_ENTITY	Plasma renin activity in acute_renal_failure induced by norepinephrine infusion in unilaterally nephrectomized dogs .
6752474	0	norepinephrine	58,72	renin	41,46	norepinephrine	renin	MESH:D009638	5972	Chemical	Gene	START_ENTITY|nsubj|responses responses|nmod|END_ENTITY	Dynamic responses of active and inactive renin and plasma norepinephrine during exercise in normal man .
690418	4	norepinephrine	730,744	renin	787,792	norepinephrine	renin	MESH:D009638	5972	Chemical	Gene	levels|nmod|START_ENTITY present|nsubj|levels present|nmod|patients patients|nmod|activity activity|compound|END_ENTITY	Significantly greater levels of plasma norepinephrine were present in patients with high plasma renin activity and lesser levels in patients with low renin activity than in normal renin or labile hypertensives .
6987097	0	norepinephrine	99,113	renin	139,144	norepinephrine	renin	MESH:D009638	5972	Chemical	Gene	concentrations|compound|START_ENTITY concentrations|nmod|activity activity|compound|END_ENTITY	-LSB- Studies on the blood pressure control mechanism in essential hypertension : the relation of plasma norepinephrine concentrations to plasma renin activity and haemodynamics -LRB- author 's transl -RRB- -RSB- .
7036720	0	norepinephrine	36,50	renin	58,63	norepinephrine	renin	MESH:D009638	5972	Chemical	Gene	effects|nmod|START_ENTITY alters|dobj|effects alters|nmod|system system|compound|END_ENTITY	Sodium intake alters the effects of norepinephrine on the renin system and the kidney .
8500238	0	norepinephrine	7,21	renin	30,35	norepinephrine	renin	MESH:D009638	5972	Chemical	Gene	START_ENTITY|appos|activity activity|compound|END_ENTITY	Plasma norepinephrine , plasma renin activity , and congestive_heart_failure .
9589751	0	norepinephrine	51,65	renin	103,108	norepinephrine	renin	MESH:D009638	5972	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Correlation between aortic pulse wave velocity and norepinephrine , epinephrine , aldosterone and plasma renin activity in very elderly subjects and in patients with congestive_heart_failure .
19545608	0	norepinephrine	51,65	substance_P	25,36	norepinephrine	substance P	MESH:D009638	6863	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|END_ENTITY	The modulatory effect of substance_P on rat pineal norepinephrine release and melatonin secretion .
2497023	3	norepinephrine	647,661	thermogenin	665,676	norepinephrine	thermogenin	MESH:D009638	22227(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Very low thermogenin mRNA levels were found in cells derived from untreated mice , and there was only little effect of added norepinephrine on thermogenin gene expression in these cells .
15929661	0	norepinephrine	20,34	thyroglobulin	38,51	norepinephrine	thyroglobulin	MESH:D009638	24826(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|compound|END_ENTITY	Long-term effect of norepinephrine on thyroglobulin gene expression in FRTL-5 cells .
15364025	0	norepinephrine	82,96	tumor_necrosis_factor-alpha	40,67	norepinephrine	tumor necrosis factor-alpha	MESH:D009638	24835(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY regulation|nmod|release regulation|amod|END_ENTITY	Amitriptyline administration transforms tumor_necrosis_factor-alpha regulation of norepinephrine release in the brain .
15672410	0	norepinephrine	88,102	tumor_necrosis_factor-alpha	10,37	norepinephrine	tumor necrosis factor-alpha	MESH:D009638	24835(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Effect of tumor_necrosis_factor-alpha on the reciprocal G-protein-induced regulation of norepinephrine release by the alpha2-adrenergic receptor .
8023943	0	norepinephrine	64,78	tumor_necrosis_factor-alpha	21,48	norepinephrine	tumor necrosis factor-alpha	MESH:D009638	24835(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY suppression|nmod|release suppression|amod|END_ENTITY	Mechanism underlying tumor_necrosis_factor-alpha suppression of norepinephrine release from rat myenteric plexus .
8144901	0	norepinephrine	11,25	tumor_necrosis_factor-alpha	36,63	norepinephrine	tumor necrosis factor-alpha	MESH:D009638	7124	Chemical	Gene	regulates|advmod|START_ENTITY regulates|dobj|production production|amod|END_ENTITY	Endogenous norepinephrine regulates tumor_necrosis_factor-alpha production from macrophages in vitro .
16076648	0	norepinephrine	84,98	tyrosine-hydroxylase	117,137	norepinephrine	tyrosine-hydroxylase	MESH:D009638	25085(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Inverse blood pressure rhythm of transgenic hypertensive TGR -LRB- mREN2 -RRB- 27_rats : role of norepinephrine and expression of tyrosine-hydroxylase and reuptake1-transporter .
14605537	0	norepinephrine	41,55	vasopressin	10,21	norepinephrine	vasopressin	MESH:D009638	551	Chemical	Gene	superior|xcomp|START_ENTITY superior|nsubj|END_ENTITY	High-dose vasopressin is not superior to norepinephrine in septic_shock .
19691818	0	norepinephrine	67,81	vasopressin	9,20	norepinephrine	vasopressin	MESH:D009638	396995(Tax:9823)	Chemical	Gene	supplement|nmod|START_ENTITY END_ENTITY|dep|supplement	Arginine vasopressin in septic shock : supplement or substitute for norepinephrine ?
22518026	0	norepinephrine	57,71	vasopressin	31,42	norepinephrine	vasopressin	MESH:D009638	551	Chemical	Gene	compared|nmod|START_ENTITY compared|nsubj|effects effects|nmod|END_ENTITY	The cardiopulmonary effects of vasopressin compared with norepinephrine in septic_shock .
23447481	0	norepinephrine	41,55	vasopressin	63,74	norepinephrine	vasopressin	MESH:D009638	551	Chemical	Gene	monotherapy|nmod|START_ENTITY comparison|nmod|monotherapy comparison|nmod|END_ENTITY	A comparison of initial monotherapy with norepinephrine versus vasopressin for resuscitation in septic_shock .
3389390	0	norepinephrine	19,33	vasopressin	56,67	norepinephrine	vasopressin	MESH:D009638	551	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Effects of infused norepinephrine and angiotensin-II on vasopressin levels in humans .
4024851	0	norepinephrine	47,61	vasopressin	4,15	norepinephrine	vasopressin	MESH:D009638	396995(Tax:9823)	Chemical	Gene	microinjections|nmod|START_ENTITY response|nmod|microinjections response|compound|END_ENTITY	The vasopressin response to microinjections of norepinephrine into the brain of the conscious pig .
947939	0	norepinephrine	10,24	vasopressin	44,55	norepinephrine	vasopressin	MESH:D009638	551	Chemical	Gene	infusion|amod|START_ENTITY Effect|nmod|infusion Effect|nmod|levels levels|compound|END_ENTITY	Effect of norepinephrine infusion on plasma vasopressin levels in normal human subjects .
12183078	0	norethisterone	25,39	Wnt-7a	0,6	norethisterone	Wnt-7a	MESH:D009640	7476	Chemical	Gene	upregulated|nmod|START_ENTITY upregulated|nsubjpass|END_ENTITY	Wnt-7a is upregulated by norethisterone in human endometrial epithelial cells : a possible mechanism by which progestogens reduce the risk of estrogen-induced endometrial_neoplasia .
1635747	0	norethisterone	11,25	angiotensin_II	49,63	norethisterone	angiotensin II	MESH:D009640	183	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of norethisterone on pressor response to angiotensin_II in men .
7581021	0	norethisterone_acetate	11,33	prolactin	57,66	norethisterone acetate	prolactin	MESH:C024262	24683(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|compound|END_ENTITY	Effects of norethisterone_acetate and tamoxifen on serum prolactin levels , uterine growth and on the presence of uterine immunoreactive prolactin in estradiol-treated ovariectomized rats .
10096258	8	norfloxacin	1682,1693	CYP1A2	1733,1739	norfloxacin	CYP1A2	MESH:D009643	1544	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|dobj|END_ENTITY	In vitro , norfloxacin and pefloxacin competitively inhibited CYP1A2 , with inhibition constant -LRB- Ki -RRB- values of 0.1 and 1 mmol/L , respectively , and CYP1A2 was the only enzyme with a relevant contribution -LRB- approximately 50 % -RRB- to pefloxacin_N-4 ' - demethylation .
1918253	0	normetanephrine	177,192	phenylethanolamine-N-methyltransferase	214,252	normetanephrine	phenylethanolamine-N-methyltransferase	MESH:D009647	24661(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activities activities|amod|END_ENTITY	High-performance liquid chromatographic determination , with ultraviolet detection , of S-adenosyl-L-methionine and S-adenosyl-L-homocysteine in rat tissues and simultaneously of normetanephrine and metanephrine for phenylethanolamine-N-methyltransferase or catechol-O-methyltransferase activities .
20640477	0	noroxoaconitine	25,40	Mapkap_kinase_5	46,61	noroxoaconitine	Mapkap kinase 5	MESH:C555605	8550	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|compound|END_ENTITY	The diterpenoid alkaloid noroxoaconitine is a Mapkap_kinase_5 -LRB- MK5/PRAK -RRB- inhibitor .
22381043	0	nortilidine	66,77	CYP2C19	16,23	nortilidine	CYP2C19	MESH:C062490	1557	Chemical	Gene	Contribution|nmod|START_ENTITY Contribution|nmod|END_ENTITY	Contribution of CYP2C19 and CYP3A4 to the formation of the active nortilidine from the prodrug tilidine .
12352271	0	nortriptyline	10,23	CYP2D6	42,48	nortriptyline	CYP2D6	MESH:D009661	1565	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|compound|END_ENTITY	Effect of nortriptyline and paroxetine on CYP2D6 activity in depressed elderly patients .
15624117	0	nortriptyline	91,104	P-glycoprotein	13,27	nortriptyline	P-glycoprotein	MESH:D009661	287115(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Influence Influence|nmod|inhibition inhibition|amod|END_ENTITY	Influence of P-glycoprotein inhibition on the distribution of the tricyclic antidepressant nortriptyline over the blood-brain barrier .
16841511	0	nortriptyline	74,87	P-glycoprotein	17,31	nortriptyline	P-glycoprotein	MESH:D009661	67078(Tax:10090)	Chemical	Gene	influence|nmod|START_ENTITY influence|nmod|END_ENTITY	The influence of P-glycoprotein on cerebral and hepatic concentrations of nortriptyline and its metabolites .
21999196	0	nortriptyline	50,63	P-glycoprotein	20,34	nortriptyline	P-glycoprotein	MESH:D009661	5243	Chemical	Gene	pharmacokinetics|amod|START_ENTITY haplotypes|nmod|pharmacokinetics haplotypes|nsubj|Influence Influence|appos|END_ENTITY	Influence of ABCB1 -LRB- P-glycoprotein -RRB- haplotypes on nortriptyline pharmacokinetics and nortriptyline-induced postural_hypotension in healthy volunteers .
20233183	0	noscapine	56,65	CYP3A4	35,41	noscapine	CYP3A4	MESH:D009665	1576	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Time-dependent inhibition -LRB- TDI -RRB- of CYP3A4 and CYP2C9 by noscapine potentially explains clinical noscapine-warfarin interaction .
25738436	0	notoginsenoside_R1	44,62	Estrogen_receptor_a	0,19	notoginsenoside R1	Estrogen receptor a	MESH:C072936	2099	Chemical	Gene	effects|nmod|START_ENTITY mediates|dobj|effects mediates|nsubj|END_ENTITY	Estrogen_receptor_a mediates the effects of notoginsenoside_R1 on endotoxin-induced inflammatory and apoptotic responses in H9c2 cardiomyocytes .
8018658	0	notoginsenoside_R1	10,28	tissue-type_plasminogen_activator	49,82	notoginsenoside R1	tissue-type plasminogen activator	MESH:C072936	5327	Chemical	Gene	START_ENTITY|nmod|synthesis synthesis|nmod|END_ENTITY	Effect of notoginsenoside_R1 on the synthesis of tissue-type_plasminogen_activator and plasminogen activator inhibitor-1 in cultured human umbilical vein endothelial cells .
22860422	0	notoginsenoside_Rg1	11,30	p38MAPK	34,41	notoginsenoside Rg1	p38MAPK	null	81649(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effect of notoginsenoside_Rg1 on p38MAPK expression of pulmonary arterial smooth muscle cells exposed to hypoxia hypercapnia -RSB- .
19935870	0	novobiocin	31,41	Hsf1	14,18	novobiocin	Hsf1	MESH:D009675	399268(Tax:8355)	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|activity activity|amod|END_ENTITY	Modulation of Hsf1 activity by novobiocin and geldanamycin .
16421106	0	novobiocin	64,74	Hsp90	103,108	novobiocin	Hsp90	MESH:D009675	3320	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Modulation of chaperone function and cochaperone interaction by novobiocin in the C-terminal domain of Hsp90 : evidence that coumarin antibiotics disrupt Hsp90 dimerization .
18304811	0	novobiocin	79,89	heat-shock_protein_90	114,135	novobiocin	heat-shock protein 90	MESH:D009675	3320	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Synthesis and biological activity of simplified denoviose-coumarins related to novobiocin as potent inhibitors of heat-shock_protein_90 -LRB- hsp90 -RRB- .
19463743	0	novokinin	20,29	AT2_receptor	46,58	novokinin	AT2 receptor	MESH:C511871	11609(Tax:10090)	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Orally administered novokinin , an angiotensin AT2_receptor agonist , suppresses food intake via prostaglandin_E2-dependent mechanism in mice .
23176213	0	novokinin	31,40	AT2_receptor	88,100	novokinin	AT2 receptor	MESH:C511871	11609(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|agonist agonist|nmod|END_ENTITY	The pharmacological effects of novokinin ; a designed peptide agonist of the angiotensin AT2_receptor .
17108323	0	nucleolin	55,64	AtNUC-L1	20,28	nucleolin	AtNUC-L1	null	841314(Tax:3702)	Chemical	Gene	role|nmod|START_ENTITY reveals|dobj|role reveals|nsubj|Characterization Characterization|nmod|END_ENTITY	Characterization of AtNUC-L1 reveals a central role of nucleolin in nucleolus organization and silencing of AtNUC-L2 gene in Arabidopsis .
8682854	0	nucleoporin	86,97	Nic96p	0,6	nucleoporin	Nic96p	null	9688	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Nic96p is required for nuclear pore formation and functionally interacts with a novel nucleoporin , Nup188p .
11290711	0	nucleoporin	42,53	Nup170p	55,62	nucleoporin	Nup170p	null	852199(Tax:4932)	Chemical	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Novel role for a Saccharomyces_cerevisiae nucleoporin , Nup170p , in chromosome segregation .
26292704	0	nucleoporin	56,67	Nup54	50,55	nucleoporin	Nup54	null	53371	Chemical	Gene	START_ENTITY|nsubj|structure structure|nmod|END_ENTITY	Crystal structure of the metazoan Nup62 Nup58 Nup54 nucleoporin complex .
10454574	0	nucleoporins	43,55	CRM1	33,37	nucleoporins	CRM1	null	399087(Tax:8355)	Chemical	Gene	interactions|nmod|START_ENTITY interactions|nmod|END_ENTITY	RanGTP-regulated interactions of CRM1 with nucleoporins and a shuttling DEAD-box helicase .
6781524	0	nucleoside	31,41	Adenosine_deaminase	0,19	nucleoside	Adenosine deaminase	CHEBI:33838	100	Chemical	Gene	activities|amod|START_ENTITY END_ENTITY|dobj|activities	Adenosine_deaminase and purine nucleoside phosphorylase activities in peripheral lymphocytes from patients with solid tumours .
6812486	0	nucleoside	21,31	Adenosine_deaminase	0,19	nucleoside	Adenosine deaminase	CHEBI:33838	100	Chemical	Gene	phosphorylase|nmod:npmod|START_ENTITY subpopulations|nsubj|phosphorylase subpopulations|advmod|END_ENTITY	Adenosine_deaminase , nucleoside phosphorylase and hypoxanthine-guanine_phosphoribosyltransferase activity in normal lymphocyte subpopulations .
10353719	0	nucleoside	74,84	CNT1	98,102	nucleoside	CNT1	CHEBI:33838	434203(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY expression|nmod|transporter expression|appos|END_ENTITY	Stable expression of a recombinant sodium-dependent , pyrimidine-selective nucleoside transporter -LRB- CNT1 -RRB- in a transport-deficient_mouse_leukemia cell line .
11451171	0	nucleoside	46,56	CNT1	70,74	nucleoside	CNT1	CHEBI:33838	116642(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY transporters|nsubj|regulation transporters|dobj|END_ENTITY	Developmental regulation of the concentrative nucleoside transporters CNT1 and CNT2 in rat liver .
12176019	0	nucleoside	57,67	CNT1	35,39	nucleoside	CNT1	CHEBI:33838	116642(Tax:10116)	Chemical	Gene	transporter|amod|START_ENTITY involved|nsubj|transporter involved|nsubj|regulation regulation|nmod|END_ENTITY	Cell-cycle-dependent regulation of CNT1 , a concentrative nucleoside transporter involved in the uptake of cell-cycle-dependent nucleoside-derived anticancer drugs .
14978229	0	nucleoside	54,64	CNT1	78,82	nucleoside	CNT1	CHEBI:33838	9154	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Functional and genetic diversity in the concentrative nucleoside transporter , CNT1 , in human populations .
16014043	0	nucleoside	28,38	CNT1	59,63	nucleoside	CNT1	CHEBI:33838	116642(Tax:10116)	Chemical	Gene	SLC28|amod|START_ENTITY SLC28|dep|END_ENTITY	Expression of concentrative nucleoside transporters SLC28 -LRB- CNT1 , CNT2 , and CNT3 -RRB- along the rat nephron : effect of diabetes .
17537394	0	nucleoside	96,106	CNT1	85,89	nucleoside	CNT1	CHEBI:33838	116642(Tax:10116)	Chemical	Gene	transporters|compound|START_ENTITY transporters|dep|END_ENTITY	Different signaling pathways utilized by insulin to regulate the expression of ENT2 , CNT1 , CNT2 nucleoside transporters in rat cardiac fibroblasts .
10721696	0	nucleoside	141,151	CNT2	165,169	nucleoside	CNT2	CHEBI:33838	269346(Tax:10090)	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Cloning , genomic organization and chromosomal localization of the gene encoding the murine sodium-dependent , purine-selective , concentrative nucleoside transporter -LRB- CNT2 -RRB- .
15861032	0	nucleoside	93,103	CNT2	117,121	nucleoside	CNT2	CHEBI:33838	9153	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Genetic analysis and functional characterization of polymorphisms in the human concentrative nucleoside transporter , CNT2 .
16390326	0	nucleoside	69,79	CNT2	49,53	nucleoside	CNT2	CHEBI:33838	60423(Tax:10116)	Chemical	Gene	cotransporter|amod|START_ENTITY END_ENTITY|appos|cotransporter	Bile_acids alter the subcellular localization of CNT2 -LRB- concentrative nucleoside cotransporter -RRB- and increase CNT2-related transport activity in liver parenchymal cells .
16840788	0	nucleoside	52,62	CNT2	116,120	nucleoside	CNT2	CHEBI:33838	9153	Chemical	Gene	specificity|nmod|START_ENTITY determinants|nmod|specificity analogs|nsubj|determinants analogs|nmod|transporter transporter|appos|END_ENTITY	Molecular determinants of specificity for synthetic nucleoside analogs in the concentrative nucleoside transporter , CNT2 .
16840788	0	nucleoside	92,102	CNT2	116,120	nucleoside	CNT2	CHEBI:33838	9153	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Molecular determinants of specificity for synthetic nucleoside analogs in the concentrative nucleoside transporter , CNT2 .
17537394	0	nucleoside	96,106	CNT2	91,95	nucleoside	CNT2	CHEBI:33838	60423(Tax:10116)	Chemical	Gene	transporters|compound|START_ENTITY transporters|dep|END_ENTITY	Different signaling pathways utilized by insulin to regulate the expression of ENT2 , CNT1 , CNT2 nucleoside transporters in rat cardiac fibroblasts .
22354287	0	nucleoside	13,23	CNT2	74,78	nucleoside	CNT2	CHEBI:33838	60423(Tax:10116)	Chemical	Gene	Mechanism|nmod|START_ENTITY uptake|nsubj|Mechanism uptake|nmod|placenta placenta|nmod|END_ENTITY	Mechanism of nucleoside uptake in rat placenta and induction of placental CNT2 in experimental diabetes .
11156964	0	nucleoside	144,154	CREB	33,37	nucleoside	CREB	CHEBI:33838	81646(Tax:10116)	Chemical	Gene	pathway|compound|START_ENTITY END_ENTITY|nmod|pathway	HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway .
8491790	0	nucleoside	17,27	CSF-1	0,5	nucleoside	CSF-1	CHEBI:33838	12977(Tax:10090)	Chemical	Gene	transport|amod|START_ENTITY stimulates|dobj|transport stimulates|nsubj|END_ENTITY	CSF-1 stimulates nucleoside transport in S1 macrophages .
11346649	0	nucleoside	98,108	Cnt1	122,126	nucleoside	Cnt1	CHEBI:33838	434203(Tax:10090)	Chemical	Gene	up-regulation|nmod|START_ENTITY transporters|nsubj|up-regulation transporters|dobj|END_ENTITY	Lipopolysaccharide-induced apoptosis of macrophages determines the up-regulation of concentrative nucleoside transporters Cnt1 and Cnt2 through tumor_necrosis_factor-alpha-dependent and - independent mechanisms .
17090699	0	nucleoside	125,135	DmENT2	90,96	nucleoside	DmENT2	CHEBI:33838	33921(Tax:7227)	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|appos|transporter	Genomic analysis of nucleoside transporters in Diptera and functional characterization of DmENT2 , a Drosophila equilibrative nucleoside transporter .
17090699	0	nucleoside	20,30	DmENT2	90,96	nucleoside	DmENT2	CHEBI:33838	33921(Tax:7227)	Chemical	Gene	analysis|nmod|START_ENTITY transporters|nsubj|analysis transporters|nmod|characterization characterization|nmod|END_ENTITY	Genomic analysis of nucleoside transporters in Diptera and functional characterization of DmENT2 , a Drosophila equilibrative nucleoside transporter .
10428086	0	nucleoside	64,74	ENT1	89,93	nucleoside	ENT1	CHEBI:33838	63997(Tax:10116)	Chemical	Gene	transporters|amod|START_ENTITY Distribution|nmod|transporters Distribution|appos|END_ENTITY	Distribution of equilibrative , nitrobenzylthioinosine-sensitive nucleoside transporters -LRB- ENT1 -RRB- in brain .
10722669	0	nucleoside	129,139	ENT1	94,98	nucleoside	ENT1	CHEBI:33838	2030	Chemical	Gene	cells|amod|START_ENTITY expressed|nmod|cells expressed|nsubj|properties properties|appos|END_ENTITY	Kinetic and pharmacological properties of cloned human equilibrative nucleoside transporters , ENT1 and ENT2 , stably expressed in nucleoside transporter-deficient PK15 cells .
10722669	0	nucleoside	69,79	ENT1	94,98	nucleoside	ENT1	CHEBI:33838	2030	Chemical	Gene	transporters|compound|START_ENTITY properties|nmod|transporters properties|appos|END_ENTITY	Kinetic and pharmacological properties of cloned human equilibrative nucleoside transporters , ENT1 and ENT2 , stably expressed in nucleoside transporter-deficient PK15 cells .
11027664	0	nucleoside	97,107	ENT1	123,127	nucleoside	ENT1	CHEBI:33838	63959(Tax:10090)	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Genomic organization and expression of the mouse equilibrative , nitrobenzylthioinosine-sensitive nucleoside transporter 1 -LRB- ENT1 -RRB- gene .
11179696	0	nucleoside	70,80	ENT1	94,98	nucleoside	ENT1	CHEBI:33838	63959(Tax:10090)	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Cloning of a novel isoform of the mouse NBMPR-sensitive equilibrative nucleoside transporter -LRB- ENT1 -RRB- lacking a putative phosphorylation site .
12061806	0	nucleoside	67,77	ENT1	129,133	nucleoside	ENT1	CHEBI:33838	2030	Chemical	Gene	transporters|amod|START_ENTITY interactions|nmod|transporters reagents|nmod|interactions effects|nmod|reagents effects|dep|evidence evidence|nmod|populations populations|nmod|transporters transporters|nummod|END_ENTITY	Complex effects of sulfhydryl reagents on ligand interactions with nucleoside transporters : evidence for multiple populations of ENT1 transporters with differential sensitivities to N-ethylmaleimide .
12724623	0	nucleoside	84,94	ENT1	108,112	nucleoside	ENT1	CHEBI:33838	2030	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Functional characterization in yeast of genetic variants in the human equilibrative nucleoside transporter , ENT1 .
15258586	2	nucleoside	243,253	ENT1	267,271	nucleoside	ENT1	CHEBI:33838	63959(Tax:10090)	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	In vitro , ethanol stimulates adenosine signaling by inhibiting the type 1 equilibrative nucleoside transporter -LRB- ENT1 -RRB- , whereas chronic ethanol exposure downregulates ENT1 .
16226730	0	nucleoside	50,60	ENT1	74,78	nucleoside	ENT1	CHEBI:33838	63997(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Localization of the NBMPR-sensitive equilibrative nucleoside transporter , ENT1 , in the rat dorsal root ganglion and lumbar spinal cord .
18289860	0	nucleoside	98,108	ENT1	124,128	nucleoside	ENT1	CHEBI:33838	2030	Chemical	Gene	START_ENTITY|dobj|activity activity|amod|1 1|dep|END_ENTITY	Constrained NBMPR analogue synthesis , pharmacophore mapping and 3D-QSAR modeling of equilibrative nucleoside transporter 1 -LRB- ENT1 -RRB- inhibitory activity .
20814156	0	nucleoside	18,28	ENT1	41,45	nucleoside	ENT1	CHEBI:33838	2030	Chemical	Gene	functions|amod|START_ENTITY functions|compound|END_ENTITY	Human erythrocyte nucleoside transporter ENT1 functions at ice-cold_temperatures .
21145879	0	nucleoside	49,59	ENT1	14,18	nucleoside	ENT1	CHEBI:33838	63959(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of ENT1 expression and ENT1-dependent nucleoside transport by c-Jun N-terminal kinase .
21455275	0	nucleoside	45,55	ENT1	71,75	nucleoside	ENT1	CHEBI:33838	2030	Chemical	Gene	START_ENTITY|dobj|transporter transporter|appos|END_ENTITY	Analysis of recombinant tagged equilibrative nucleoside transporter 1 -LRB- ENT1 -RRB- expressed in E. __ coli .
21872611	0	nucleoside	25,35	ENT1	53,57	nucleoside	ENT1	CHEBI:33838	63959(Tax:10090)	Chemical	Gene	transporter|amod|START_ENTITY transporter|nmod|mice mice|compound|END_ENTITY	Absence of equilibrative nucleoside transporter 1 in ENT1 knockout mice leads to altered nucleoside levels following hypoxic challenge .
21872611	0	nucleoside	89,99	ENT1	53,57	nucleoside	ENT1	CHEBI:33838	63959(Tax:10090)	Chemical	Gene	levels|compound|START_ENTITY leads|nmod|levels leads|nsubj|Absence Absence|nmod|transporter transporter|nmod|mice mice|compound|END_ENTITY	Absence of equilibrative nucleoside transporter 1 in ENT1 knockout mice leads to altered nucleoside levels following hypoxic challenge .
25454272	0	nucleoside	49,59	ENT1	82,86	nucleoside	ENT1	CHEBI:33838	2030	Chemical	Gene	study|nmod|START_ENTITY analogues|nmod|study transporters|nsubj|analogues transporters|dobj|1 1|appos|END_ENTITY	Dilazep analogues for the study of equilibrative nucleoside transporters 1 and 2 -LRB- ENT1 and ENT2 -RRB- .
11463208	0	nucleoside	143,153	ENT2	137,141	nucleoside	ENT2	CHEBI:33838	3177	Chemical	Gene	proteins|amod|START_ENTITY proteins|amod|insensitive insensitive|dep|END_ENTITY	Transport of antiviral 3 ' - deoxy-nucleoside drugs by recombinant human and rat equilibrative , nitrobenzylthioinosine -LRB- NBMPR -RRB- - insensitive -LRB- ENT2 -RRB- nucleoside transporter proteins produced in Xenopus oocytes .
16214850	0	nucleoside	95,105	ENT2	119,123	nucleoside	ENT2	CHEBI:33838	3177	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Functional characterization and haplotype analysis of polymorphisms in the human equilibrative nucleoside transporter , ENT2 .
17473446	0	nucleoside	20,30	ENT2	128,132	nucleoside	ENT2	CHEBI:33838	13340(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|nucleosides nucleosides|acl|differing differing|nmod|END_ENTITY	Mouse equilibrative nucleoside transporter 2 -LRB- mENT2 -RRB- transports nucleosides and purine nucleobases differing from human and rat ENT2 .
10490534	0	nucleoside	72,82	IL-18	5,10	nucleoside	IL-18	CHEBI:33838	3606	Chemical	Gene	concentration|nmod|START_ENTITY concentration|compound|END_ENTITY	High IL-18 -LRB- interferon-gamma inducing factor -RRB- concentration in a purine nucleoside phosphorylase deficient patient .
18078872	0	nucleoside	38,48	IL-4	82,86	nucleoside	IL-4	CHEBI:33838	3565	Chemical	Gene	START_ENTITY|dobj|activity activity|nmod|END_ENTITY	Modulation of the human equilibrative nucleoside transporter1 -LRB- hENT1 -RRB- activity by IL-4 and PMA in B cells from chronic_lymphocytic_leukemia .
1667585	0	nucleoside	85,95	Rev	51,54	nucleoside	Rev	CHEBI:33838	19714(Tax:10090)	Chemical	Gene	protein|nmod|START_ENTITY protein|compound|END_ENTITY	Interaction of human immunodeficiency virus type I Rev protein with nuclear scaffold nucleoside triphosphatase activity .
6467191	0	nucleoside	91,101	S-adenosylhomocysteinase	47,71	nucleoside	S-adenosylhomocysteinase	CHEBI:33838	29443(Tax:10116)	Chemical	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	Inactivation and reactivation of intracellular S-adenosylhomocysteinase in the presence of nucleoside analogues in rat hepatocytes .
10213491	0	nucleoside	92,102	S-adenosylhomocysteine_hydrolase	126,158	nucleoside	S-adenosylhomocysteine hydrolase	CHEBI:33838	269378(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|inhibitors inhibitors|nmod|END_ENTITY	S-adenosylmethionine synthetase is overexpressed in murine neuroblastoma cells resistant to nucleoside analogue inhibitors of S-adenosylhomocysteine_hydrolase : a novel mechanism of drug resistance .
15861042	0	nucleoside	82,92	SLC28A3	115,122	nucleoside	SLC28A3	CHEBI:33838	64078	Chemical	Gene	START_ENTITY|dobj|transporter transporter|appos|END_ENTITY	Identification and functional characterization of variants in human concentrative nucleoside transporter 3 , hCNT3 -LRB- SLC28A3 -RRB- , arising from single nucleotide polymorphisms in coding regions of the hCNT3 gene .
18827020	0	nucleoside	73,83	SLC28A3	24,31	nucleoside	SLC28A3	CHEBI:33838	64078	Chemical	Gene	encodes|ccomp|START_ENTITY encodes|nsubj|variant variant|nmod|gene gene|compound|END_ENTITY	A splice variant of the SLC28A3 gene encodes a novel human concentrative nucleoside transporter-3 -LRB- hCNT3 -RRB- protein localized in the endoplasmic reticulum .
9144579	0	nucleoside	38,48	SPNT	58,62	nucleoside	SPNT	CHEBI:33838	60423(Tax:10116)	Chemical	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	Expression of sodium-dependent purine nucleoside carrier -LRB- SPNT -RRB- mRNA correlates with nucleoside transport activity in rat liver .
15493835	0	nucleoside	29,39	Salvianolic_acid_A	1,19	nucleoside	Salvianolic acid A	CHEBI:33838	111345(Tax:10090)	Chemical	Gene	transport|amod|START_ENTITY inhibits|dobj|transport inhibits|nsubj|END_ENTITY	-LSB- Salvianolic_acid_A inhibits nucleoside transport and potentiates the antitumor activity of chemotherapeutic drugs -RSB- .
17890166	0	nucleoside	61,71	ZAP3	36,40	nucleoside	ZAP3	CHEBI:33838	56252	Chemical	Gene	kinase|compound|START_ENTITY kinase|nsubj|END_ENTITY	The nuclear PP1 interacting protein ZAP3 -LRB- ZAP -RRB- is a putative nucleoside kinase that complexes with SAM68 , CIA , NF110/45 , and HNRNP-G .
1112066	0	nucleoside	43,53	adenosine_deaminase	12,31	nucleoside	adenosine deaminase	CHEBI:33838	100	Chemical	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Erythrocyte adenosine_deaminase and purine nucleoside phosphorylase activity in gout .
3149955	0	nucleoside	48,58	adenosine_deaminase	17,36	nucleoside	adenosine deaminase	CHEBI:33838	100	Chemical	Gene	START_ENTITY|nsubj|Determination Determination|nmod|END_ENTITY	Determination of adenosine_deaminase and purine nucleoside phosphorylase activities using high-performance liquid chromatographic and radiochromatographic methods .
3922455	0	nucleoside	40,50	adenosine_deaminase	9,28	nucleoside	adenosine deaminase	CHEBI:33838	100	Chemical	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Elevated adenosine_deaminase and purine nucleoside phosphorylase activity in peripheral blood null lymphocytes from patients with acquired immune_deficiency syndrome .
412622	0	nucleoside	61,71	adenosine_deaminase	30,49	nucleoside	adenosine deaminase	CHEBI:33838	100	Chemical	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	A micromethod for determining adenosine_deaminase and purine nucleoside phosphorylase activity in cells from human peripheral blood .
6217925	0	nucleoside	40,50	adenosine_deaminase	12,31	nucleoside	adenosine deaminase	CHEBI:33838	100	Chemical	Gene	phosphorylase|compound|START_ENTITY phosphorylase|amod|END_ENTITY	Erythrocyte adenosine_deaminase , purine nucleoside phosphorylase and phosphoribosyltransferase activity in patients with Down 's _ syndrome .
8762052	0	nucleoside	68,78	adenosine_deaminase	41,60	nucleoside	adenosine deaminase	CHEBI:33838	24165(Tax:10116)	Chemical	Gene	inhibitor|amod|START_ENTITY END_ENTITY|nmod|inhibitor	Transient ischemia in the presence of an adenosine_deaminase plus a nucleoside transport inhibitor confers protection against contractile depression produced by hydrogen_peroxide .
947948	0	nucleoside	7,17	adenosine_deaminase	66,85	nucleoside	adenosine deaminase	CHEBI:33838	100	Chemical	Gene	START_ENTITY|nmod|deficiency deficiency|amod|END_ENTITY	Purine nucleoside metabolism in the erythrocytes of patients with adenosine_deaminase deficiency and severe combined immunodeficiency .
26066576	0	nucleoside	120,130	adenosine_kinase	3,19	nucleoside	adenosine kinase	D009705	25368(Tax:10116)	Chemical	Gene	transporters|compound|START_ENTITY release|nmod|transporters inhibits|nmod|release inhibits|nsubj|inhibitor inhibitor|amod|END_ENTITY	An adenosine_kinase inhibitor , ABT-702 , inhibits spinal nociceptive transmission by adenosine release via equilibrative nucleoside transporters in rat .
2984788	0	nucleoside	46,56	adenosine_kinase	28,44	nucleoside	adenosine kinase	CHEBI:33838	11534(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|localization localization|nmod|END_ENTITY	Cytological localization of adenosine_kinase , nucleoside phosphorylase-1 , and esterase-10 genes on mouse chromosome 14 .
9342249	0	nucleoside	105,115	adenosine_kinase	58,74	nucleoside	adenosine kinase	CHEBI:33838	783572(Tax:9913)	Chemical	Gene	analogues|compound|START_ENTITY END_ENTITY|nmod|analogues	Study of the substrate-binding properties of bovine liver adenosine_kinase and inhibition by fluorescent nucleoside analogues .
11961068	0	nucleoside	14,24	albumin	59,66	nucleoside	albumin	CHEBI:33838	213	Chemical	Gene	analogs|amod|START_ENTITY analogs|nmod|END_ENTITY	Conjugates of nucleoside analogs with lactosaminated human albumin to selectively increase the drug levels in liver blood : requirements for a regional chemotherapy .
16130519	0	nucleoside	90,100	breast_cancer_resistance_protein	12,44	nucleoside	breast cancer resistance protein	CHEBI:33838	9429	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	The role of breast_cancer_resistance_protein -LRB- BCRP/ABCG2 -RRB- in cellular resistance to HIV-1 nucleoside reverse transcriptase inhibitors .
24972933	0	nucleoside	118,128	deoxycytidine_kinase	18,38	nucleoside	deoxycytidine kinase	CHEBI:33838	1633	Chemical	Gene	analogs|amod|START_ENTITY cross-resistance|nmod|analogs confers|xcomp|cross-resistance confers|nsubj|Downregulation Downregulation|nmod|END_ENTITY	Downregulation of deoxycytidine_kinase in cytarabine-resistant mantle cell lymphoma cells confers cross-resistance to nucleoside analogs gemcitabine , fludarabine and cladribine , but not to other classes of anti-lymphoma agents .
22086444	0	nucleoside	77,87	dihydropyrimidine_dehydrogenase	21,52	nucleoside	dihydropyrimidine dehydrogenase	CHEBI:33838	1806	Chemical	Gene	transporter|amod|START_ENTITY transporter|amod|END_ENTITY	Combined analysis of dihydropyrimidine_dehydrogenase and human equilibrative nucleoside transporter 1 expression predicts survival of pancreatic_carcinoma patients treated with adjuvant gemcitabine plus S-1 chemotherapy after surgical resection .
10455109	0	nucleoside	80,90	hCNT1	160,165	nucleoside	hCNT1	CHEBI:33838	9154	Chemical	Gene	specificities|amod|START_ENTITY responsible|nmod|specificities residues|amod|responsible Identification|nmod|residues nucleoside|nsubj|Identification nucleoside|dobj|END_ENTITY	Identification of amino_acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na -LRB- + -RRB- _ nucleoside cotransporters hCNT1 and hCNT2 .
11353816	0	nucleoside	32,42	hCNT1	56,61	nucleoside	hCNT1	CHEBI:33838	9154	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Role of the human concentrative nucleoside transporter -LRB- hCNT1 -RRB- in the cytotoxic action of 5 -LSB- Prime -RSB- - deoxy-5-fluorouridine , an active intermediate metabolite of capecitabine , a novel oral anticancer drug .
14978234	0	nucleoside	36,46	hCNT1	60,65	nucleoside	hCNT1	CHEBI:33838	9154	Chemical	Gene	requirements|nmod|START_ENTITY transporters|nsubj|requirements transporters|dobj|END_ENTITY	Molecular requirements of the human nucleoside transporters hCNT1 , hCNT2 , and hENT1 .
15194733	0	nucleoside	73,83	hCNT1	97,102	nucleoside	hCNT1	CHEBI:33838	9154	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Electrophysiological characterization of a recombinant human Na + - coupled nucleoside transporter -LRB- hCNT1 -RRB- produced in Xenopus oocytes .
17453413	0	nucleoside	50,60	hCNT1	74,79	nucleoside	hCNT1	CHEBI:33838	9154	Chemical	Gene	properties|nmod|START_ENTITY transporters|nsubj|properties transporters|dobj|END_ENTITY	Cation coupling properties of human concentrative nucleoside transporters hCNT1 , hCNT2 and hCNT3 .
17704058	0	nucleoside	60,70	hCNT1	132,137	nucleoside	hCNT1	CHEBI:33838	9154	Chemical	Gene	cotransport|amod|START_ENTITY involved|nmod|cotransport involved|nmod|concentrative_nucleoside_transporter_1 concentrative_nucleoside_transporter_1|appos|END_ENTITY	Conserved glutamate residues are critically involved in Na + / nucleoside cotransport by human concentrative_nucleoside_transporter_1 -LRB- hCNT1 -RRB- .
23722537	0	nucleoside	14,24	hCNT1	40,45	nucleoside	hCNT1	CHEBI:33838	9154	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Concentrative nucleoside transporter 1 -LRB- hCNT1 -RRB- promotes phenotypic changes relevant to tumor biology in a translocation-independent manner .
9124315	0	nucleoside	74,84	hCNT1	100,105	nucleoside	hCNT1	CHEBI:33838	9154	Chemical	Gene	cotransporter|amod|START_ENTITY cotransporter|appos|END_ENTITY	Molecular cloning and functional expression of cDNAs encoding a human Na + - nucleoside cotransporter -LRB- hCNT1 -RRB- .
10087507	0	nucleoside	101,111	hCNT2	127,132	nucleoside	hCNT2	CHEBI:33838	9153	Chemical	Gene	cotransporter|compound|START_ENTITY cotransporter|appos|END_ENTITY	Molecular cloning , functional expression and chromosomal localization of a cDNA encoding a human Na + / nucleoside cotransporter -LRB- hCNT2 -RRB- selective for purine_nucleosides and uridine .
15486050	3	nucleoside	685,695	hCNT2	742,747	nucleoside	hCNT1	CHEBI:33838	9154	Chemical	Gene	types|amod|START_ENTITY types|dep|hENT1 hENT1|appos|hCNT1 hCNT1|nummod|END_ENTITY	Transportability was examined in Xenopus_laevis oocytes and Saccharomyces_cerevisiae that produced individual recombinant human concentrative nucleoside transporter -LRB- CNT -RRB- and equilibrative nucleoside transporter -LRB- ENT -RRB- types -LRB- hENT1 , hENT2 , hCNT1 , hCNT2 , or hCNT3 -RRB- .
16462026	0	nucleoside	26,36	hCNT2	49,54	nucleoside	hCNT2	CHEBI:33838	9153	Chemical	Gene	Interaction|nmod|START_ENTITY END_ENTITY|dep|Interaction	Interaction of intestinal nucleoside transporter hCNT2 with amino_acid ester prodrugs of floxuridine and 2-bromo-5 ,6 - dichloro-1-beta-D-ribofuranosylbenzimidazole .
24957263	0	nucleoside	123,133	hCNT2	147,152	nucleoside	hCNT2	CHEBI:33838	9153	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Ribavirin uptake into human hepatocyte HHL5 cells is enhanced by interferon-a via up-regulation of the human concentrative nucleoside transporter -LRB- hCNT2 -RRB- .
11032837	0	nucleoside	89,99	hCNT3	124,129	nucleoside	hCNT3	CHEBI:33838	64078	Chemical	Gene	proteins|amod|START_ENTITY proteins|dep|END_ENTITY	Molecular identification and characterization of novel human and mouse concentrative Na + - nucleoside cotransporter proteins -LRB- hCNT3 and mCNT3 -RRB- broadly selective for purine and pyrimidine_nucleosides -LRB- system cib -RRB- .
11396613	0	nucleoside	72,82	hCNT3	180,185	nucleoside	hCNT3	CHEBI:33838	64078	Chemical	Gene	transporter|amod|START_ENTITY advances|dep|transporter advances|dep|identification identification|nmod|human human|dep|END_ENTITY	Recent molecular advances in studies of the concentrative Na + - dependent nucleoside transporter -LRB- CNT -RRB- family : identification and characterization of novel human and mouse proteins -LRB- hCNT3 and mCNT3 -RRB- broadly selective for purine and pyrimidine_nucleosides -LRB- system cib -RRB- .
14504928	0	nucleoside	80,90	hCNT3	114,119	nucleoside	hCNT3	CHEBI:33838	64078	Chemical	Gene	isoform|amod|START_ENTITY isoform|appos|END_ENTITY	Genomic organization and functional characterization of the human concentrative nucleoside transporter-3 isoform -LRB- hCNT3 -RRB- expressed in mammalian cells .
15861042	0	nucleoside	82,92	hCNT3	108,113	nucleoside	hCNT3	CHEBI:33838	64078	Chemical	Gene	START_ENTITY|dobj|transporter transporter|nummod|END_ENTITY	Identification and functional characterization of variants in human concentrative nucleoside transporter 3 , hCNT3 -LRB- SLC28A3 -RRB- , arising from single nucleotide polymorphisms in coding regions of the hCNT3 gene .
15861042	0	nucleoside	82,92	hCNT3	195,200	nucleoside	hCNT3	CHEBI:33838	64078	Chemical	Gene	START_ENTITY|dobj|transporter transporter|acl|arising arising|nmod|regions regions|nmod|gene gene|amod|END_ENTITY	Identification and functional characterization of variants in human concentrative nucleoside transporter 3 , hCNT3 -LRB- SLC28A3 -RRB- , arising from single nucleotide polymorphisms in coding regions of the hCNT3 gene .
15870078	0	nucleoside	32,42	hCNT3	58,63	nucleoside	hCNT3	CHEBI:33838	64078	Chemical	Gene	cotransporter|compound|START_ENTITY cotransporter|appos|END_ENTITY	The broadly selective human Na + / nucleoside cotransporter -LRB- hCNT3 -RRB- exhibits novel cation-coupled nucleoside transport characteristics .
15870078	0	nucleoside	95,105	hCNT3	58,63	nucleoside	hCNT3	CHEBI:33838	64078	Chemical	Gene	characteristics|amod|START_ENTITY exhibits|dobj|characteristics exhibits|nsubj|cotransporter cotransporter|appos|END_ENTITY	The broadly selective human Na + / nucleoside cotransporter -LRB- hCNT3 -RRB- exhibits novel cation-coupled nucleoside transport characteristics .
16446384	0	nucleoside	117,127	hCNT3	143,148	nucleoside	hCNT3	CHEBI:33838	64078	Chemical	Gene	START_ENTITY|dobj|3 3|appos|END_ENTITY	Electrophysiological characterization and modeling of the structure activity relationship of the human concentrative nucleoside transporter 3 -LRB- hCNT3 -RRB- .
18827020	0	nucleoside	73,83	hCNT3	99,104	nucleoside	hCNT3	CHEBI:33838	64078	Chemical	Gene	START_ENTITY|dobj|protein protein|appos|END_ENTITY	A splice variant of the SLC28A3 gene encodes a novel human concentrative nucleoside transporter-3 -LRB- hCNT3 -RRB- protein localized in the endoplasmic reticulum .
19097778	0	nucleoside	81,91	hCNT3	107,112	nucleoside	hCNT3	CHEBI:33838	64078	Chemical	Gene	START_ENTITY|ccomp|inhibitors inhibitors|nsubj|transporter transporter|appos|END_ENTITY	Synthesis and biological evaluation of phloridzin analogs as human concentrative nucleoside transporter 3 -LRB- hCNT3 -RRB- inhibitors .
20495821	0	nucleoside	94,104	hCNT3	120,125	nucleoside	hCNT3	CHEBI:33838	64078	Chemical	Gene	START_ENTITY|dobj|3 3|appos|END_ENTITY	Effects of Na + and H + on steady-state and presteady-state currents of the human concentrative nucleoside transporter 3 -LRB- hCNT3 -RRB- .
10085223	0	nucleoside	68,78	hENT1	92,97	nucleoside	hENT1	CHEBI:33838	2030	Chemical	Gene	transporter|compound|START_ENTITY production|nmod|transporter production|appos|END_ENTITY	Functional production and reconstitution of the human equilibrative nucleoside transporter -LRB- hENT1 -RRB- in Saccharomyces_cerevisiae .
10085223	1	nucleoside	157,167	hENT1	195,200	nucleoside	hENT1	CHEBI:33838	2030	Chemical	Gene	transport|amod|START_ENTITY inhibitors|nmod|transport Interaction|nmod|inhibitors Interaction|nmod|END_ENTITY	Interaction of inhibitors of nucleoside transport with recombinant hENT1 and a glycosylation-defective derivative -LRB- hENT1/N48Q -RRB- .
11311901	0	nucleoside	54,64	hENT1	95,100	nucleoside	hENT1	CHEBI:33838	2030	Chemical	Gene	distribution|nmod|START_ENTITY transporter|nsubj|distribution transporter|dobj|proteins proteins|dep|END_ENTITY	Distinct regional distribution of human equilibrative nucleoside transporter proteins 1 and 2 -LRB- hENT1 and hENT2 -RRB- in the central nervous system .
11584005	0	nucleoside	76,86	hENT1	100,105	nucleoside	hENT1	CHEBI:33838	2030	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Topology of a human equilibrative , nitrobenzylthioinosine -LRB- NBMPR -RRB- - sensitive nucleoside transporter -LRB- hENT1 -RRB- implicated in the cellular uptake of adenosine and anti-cancer drugs .
11814344	0	nucleoside	47,57	hENT1	76,81	nucleoside	hENT1	CHEBI:33838	2030	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A single glycine mutation in the equilibrative nucleoside transporter gene , hENT1 , alters nucleoside transport activity and sensitivity to nitrobenzylthioinosine .
11814344	0	nucleoside	90,100	hENT1	76,81	nucleoside	hENT1	CHEBI:33838	2030	Chemical	Gene	activity|amod|START_ENTITY alters|dobj|activity alters|nsubj|mutation mutation|nmod|gene gene|appos|END_ENTITY	A single glycine mutation in the equilibrative nucleoside transporter gene , hENT1 , alters nucleoside transport activity and sensitivity to nitrobenzylthioinosine .
12062437	0	nucleoside	42,52	hENT1	66,71	nucleoside	hENT1	CHEBI:33838	2030	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	PKC regulation of the human equilibrative nucleoside transporter , hENT1 .
12389626	0	nucleoside	47,57	hENT1	73,78	nucleoside	hENT1	CHEBI:33838	2030	Chemical	Gene	START_ENTITY|dobj|protein protein|amod|1 1|dep|END_ENTITY	Differential expression of human equilibrative nucleoside transporter 1 -LRB- hENT1 -RRB- protein in the Reed-Sternberg cells of Hodgkin 's _ disease .
14607828	0	nucleoside	52,62	hENT1	78,83	nucleoside	hENT1	CHEBI:33838	2030	Chemical	Gene	START_ENTITY|dobj|results results|amod|1 1|dep|END_ENTITY	Mitochondrial expression of the human equilibrative nucleoside transporter 1 -LRB- hENT1 -RRB- results in enhanced mitochondrial_toxicity of antiviral drugs .
14759222	0	nucleoside	179,189	hENT1	203,208	nucleoside	hENT1	CHEBI:33838	2030	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Mutation of leucine-92 selectively reduces the apparent affinity of inosine , guanosine , NBMPR -LSB- S6 - -LRB- 4-nitrobenzyl -RRB- - mercaptopurine_riboside -RSB- and dilazep for the human equilibrative nucleoside transporter , hENT1 .
15037197	0	nucleoside	33,43	hENT1	57,62	nucleoside	hENT1	CHEBI:33838	2030	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Glycine 154 of the equilibrative nucleoside transporter , hENT1 , is important for nucleoside transport and for conferring sensitivity to the inhibitors nitrobenzylthioinosine , dipyridamole , and dilazep .
15037197	0	nucleoside	81,91	hENT1	57,62	nucleoside	hENT1	CHEBI:33838	2030	Chemical	Gene	transport|amod|START_ENTITY important|nmod|transport important|nsubj|Glycine Glycine|nmod|transporter transporter|appos|END_ENTITY	Glycine 154 of the equilibrative nucleoside transporter , hENT1 , is important for nucleoside transport and for conferring sensitivity to the inhibitors nitrobenzylthioinosine , dipyridamole , and dilazep .
15529184	0	nucleoside	32,42	hENT1	58,63	nucleoside	hENT1	CHEBI:33838	2030	Chemical	Gene	START_ENTITY|dobj|protein protein|amod|1 1|dep|END_ENTITY	Analysis of human equilibrative nucleoside transporter 1 -LRB- hENT1 -RRB- protein in non-Hodgkin 's _ lymphoma by immunohistochemistry .
16595656	0	nucleoside	80,90	hENT1	106,111	nucleoside	hENT1	CHEBI:33838	2030	Chemical	Gene	START_ENTITY|dobj|transporter transporter|appos|END_ENTITY	Identification of the mitochondrial targeting signal of the human equilibrative nucleoside transporter 1 -LRB- hENT1 -RRB- : implications for interspecies differences in mitochondrial_toxicity of fialuridine .
16818276	0	nucleoside	34,44	hENT1	60,65	nucleoside	hENT1	CHEBI:33838	2030	Chemical	Gene	START_ENTITY|dobj|transporter transporter|appos|END_ENTITY	Expression of human equilibrative nucleoside transporter 1 -LRB- hENT1 -RRB- and its correlation with gemcitabine uptake and cytotoxicity in mantle_cell_lymphoma .
16858130	0	nucleoside	81,91	hENT1	107,112	nucleoside	hENT1	CHEBI:33838	2030	Chemical	Gene	START_ENTITY|dobj|1 1|appos|END_ENTITY	Thirty novel genetic variations in the SLC29A1 gene encoding human equilibrative nucleoside transporter 1 -LRB- hENT1 -RRB- .
16965766	0	nucleoside	20,30	hENT1	46,51	nucleoside	hENT1	CHEBI:33838	2030	Chemical	Gene	transporter-1|compound|START_ENTITY transporter-1|appos|END_ENTITY	Human equilibrative nucleoside transporter-1 -LRB- hENT1 -RRB- is required for the transcriptomic response of the nucleoside-derived drug 5 ' - DFUR in breast_cancer MCF7 cells .
17162590	0	nucleoside	85,95	hENT1	114,119	nucleoside	hENT1	CHEBI:33838	2030	Chemical	Gene	START_ENTITY|dobj|gene gene|appos|END_ENTITY	Characterization and functional analysis of the promoter for the human equilibrative nucleoside transporter gene , hENT1 .
18078872	0	nucleoside	38,48	hENT1	63,68	nucleoside	hENT1	CHEBI:33838	2030	Chemical	Gene	START_ENTITY|dobj|activity activity|appos|END_ENTITY	Modulation of the human equilibrative nucleoside transporter1 -LRB- hENT1 -RRB- activity by IL-4 and PMA in B cells from chronic_lymphocytic_leukemia .
18187485	0	nucleoside	20,30	hENT1	46,51	nucleoside	hENT1	CHEBI:33838	2030	Chemical	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Human equilibrative nucleoside transporter 1 -LRB- hENT1 -RRB- protein is associated with short survival in resected ampullary_cancer .
18589402	0	nucleoside	58,68	hENT1	84,89	nucleoside	hENT1	CHEBI:33838	2030	Chemical	Gene	START_ENTITY|ccomp|enhances enhances|nsubj|transporter transporter|appos|END_ENTITY	Adenoviral-mediated overexpression of human equilibrative nucleoside transporter 1 -LRB- hENT1 -RRB- enhances gemcitabine response in human pancreatic_cancer .
19091561	0	nucleoside	133,143	hENT1	159,164	nucleoside	hENT1	CHEBI:33838	2030	Chemical	Gene	START_ENTITY|dobj|1 1|appos|END_ENTITY	CoMFA and CoMSIA 3D-QSAR studies on S -LRB- 6 -RRB- - -LRB- 4-nitrobenzyl -RRB- mercaptopurine_riboside -LRB- NBMPR -RRB- analogs as inhibitors of human equilibrative nucleoside transporter 1 -LRB- hENT1 -RRB- .
19297449	0	nucleoside	109,119	hENT1	133,138	nucleoside	hENT1	CHEBI:33838	2030	Chemical	Gene	transporters|amod|START_ENTITY roles|nmod|transporters roles|dep|END_ENTITY	Transepithelial fluxes of adenosine and 2 ' - deoxyadenosine across human renal proximal tubule cells : roles of nucleoside transporters hENT1 , hENT2 , and hCNT3 .
20578980	0	nucleoside	20,30	hENT1	46,51	nucleoside	hENT1	CHEBI:33838	2030	Chemical	Gene	START_ENTITY|ccomp|predict predict|nsubj|levels levels|appos|END_ENTITY	Human equilibrative nucleoside transporter 1 -LRB- hENT1 -RRB- levels predict response to gemcitabine in patients with biliary_tract_cancer -LRB- BTC -RRB- .
20718495	0	nucleoside	179,189	hENT1	205,210	nucleoside	hENT1	CHEBI:33838	2030	Chemical	Gene	START_ENTITY|dobj|levels levels|amod|1 1|dep|END_ENTITY	Improved syntheses of 5 ' - S - -LRB- 2-aminoethyl -RRB- -6 - N - -LRB- 4-nitrobenzyl -RRB- -5 ' - thioadenosine -LRB- SAENTA -RRB- , analogues , and fluorescent probe conjugates : analysis of cell-surface human equilibrative nucleoside transporter 1 -LRB- hENT1 -RRB- levels for prediction of the antitumor efficacy of gemcitabine .
21586890	0	nucleoside	52,62	hENT1	77,82	nucleoside	hENT1	CHEBI:33838	2030	Chemical	Gene	START_ENTITY|dobj|expression expression|appos|END_ENTITY	-LSB- The prognostic significance of human equilibrative nucleoside transporter1 -LRB- hENT1 -RRB- expression in metastatic bladder_cancer patients treated with gemcitabine-cisplatin based combination chemotherapy -RSB- .
21795683	0	nucleoside	44,54	hENT1	70,75	nucleoside	hENT1	CHEBI:33838	2030	Chemical	Gene	START_ENTITY|dobj|1 1|appos|END_ENTITY	Nucleobase transport by human equilibrative nucleoside transporter 1 -LRB- hENT1 -RRB- .
21913012	0	nucleoside	52,62	hENT1	78,83	nucleoside	hENT1	CHEBI:33838	2030	Chemical	Gene	transporter-1|amod|START_ENTITY equilibrative|amod|transporter-1 equilibrative|appos|END_ENTITY	Immunohistochemical analysis of human equilibrative nucleoside transporter-1 -LRB- hENT1 -RRB- predicts survival in resected pancreatic_cancer patients treated with adjuvant gemcitabine monotherapy .
22137164	0	nucleoside	20,30	hENT1	46,51	nucleoside	hENT1	CHEBI:33838	2030	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Human equilibrative nucleoside transporter 1 -LRB- hENT1 -RRB- expression is a potential predictive tool for response to gemcitabine in patients with advanced cholangiocarcinoma .
23253379	0	nucleoside	54,64	hENT1	80,85	nucleoside	hENT1	CHEBI:33838	2030	Chemical	Gene	START_ENTITY|ccomp|predictor predictor|nsubj|1 1|appos|END_ENTITY	Combined analysis of intratumoral human equilibrative nucleoside transporter 1 -LRB- hENT1 -RRB- and ribonucleotide reductase regulatory subunit M1 -LRB- RRM1 -RRB- expression is a powerful predictor of survival in patients with pancreatic_carcinoma treated with adjuvant gemcitabine-based chemotherapy after operative resection .
23574652	0	nucleoside	20,30	hENT1	46,51	nucleoside	hENT1	CHEBI:33838	2030	Chemical	Gene	START_ENTITY|ccomp|predicts predicts|nsubj|transporter transporter|appos|END_ENTITY	Human equilibrative nucleoside transporter 1 -LRB- hENT1 -RRB- predicts the Asian patient response to gemcitabine-based chemotherapy in pancreatic_cancer .
24874245	0	nucleoside	30,40	hENT1	61,66	nucleoside	hENT1	CHEBI:33838	2030	Chemical	Gene	Targeting|dep|START_ENTITY Targeting|nsubj|transporter transporter|appos|END_ENTITY	Targeting human equilibrative nucleoside analog transporter -LRB- hENT1 -RRB- expression through modified low glycemic index diet in pancreatic_cancer .
25725289	0	nucleoside	63,73	hENT1	89,94	nucleoside	hENT1	CHEBI:33838	2030	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Adenosine A1 receptor activation modulates human equilibrative nucleoside transporter 1 -LRB- hENT1 -RRB- activity via PKC-mediated phosphorylation of serine-281 .
26162242	0	nucleoside	80,90	hENT1	114,119	nucleoside	hENT1	D009705	2030	Chemical	Gene	characterization|nmod|START_ENTITY transporter|nsubj|characterization transporter|dobj|protein protein|appos|END_ENTITY	Expression , purification and functional characterization of human equilibrative nucleoside transporter subtype-1 -LRB- hENT1 -RRB- protein from Sf9 insect cells .
9705281	0	nucleoside	56,66	hENT1	105,110	nucleoside	hENT1	CHEBI:33838	2030	Chemical	Gene	transporters|amod|START_ENTITY constructs|nmod|transporters reveal|nsubj|constructs reveal|dobj|domains domains|amod|END_ENTITY	Chimeric constructs between human and rat equilibrative nucleoside transporters -LRB- hENT1 and rENT1 -RRB- reveal hENT1 structural domains interacting with coronary vasoactive drugs .
9705281	0	nucleoside	56,66	hENT1	81,86	nucleoside	hENT1	CHEBI:33838	2030	Chemical	Gene	transporters|amod|START_ENTITY constructs|nmod|transporters constructs|dep|END_ENTITY	Chimeric constructs between human and rat equilibrative nucleoside transporters -LRB- hENT1 and rENT1 -RRB- reveal hENT1 structural domains interacting with coronary vasoactive drugs .
9804860	0	nucleoside	31,41	hENT1	56,61	nucleoside	hENT1	CHEBI:33838	2030	Chemical	Gene	transporters|compound|START_ENTITY Demonstration|nmod|transporters Demonstration|dep|END_ENTITY	Demonstration of equilibrative nucleoside transporters -LRB- hENT1 and hENT2 -RRB- in nuclear envelopes of cultured human choriocarcinoma -LRB- BeWo -RRB- cells by functional reconstitution in proteoliposomes .
10733507	0	nucleoside	33,43	hENT2	27,32	nucleoside	hENT2	CHEBI:33838	3177	Chemical	Gene	cDNA|amod|START_ENTITY cDNA|amod|END_ENTITY	Retroviral transfer of the hENT2 nucleoside transporter cDNA confers broad-spectrum antifolate resistance in murine bone_marrow_cells .
12440703	0	nucleoside	131,141	hENT2	157,162	nucleoside	hENT2	CHEBI:33838	3177	Chemical	Gene	START_ENTITY|dobj|transporter transporter|appos|END_ENTITY	Comparison of the interaction of uridine , cytidine , and other pyrimidine_nucleoside analogues with recombinant human equilibrative nucleoside transporter 2 -LRB- hENT2 -RRB- produced in Saccharomyces_cerevisiae .
15510196	0	nucleoside	14,24	hENT2	40,45	nucleoside	hENT2	CHEBI:33838	3177	Chemical	Gene	correlates|amod|START_ENTITY correlates|appos|END_ENTITY	Equilibrative nucleoside transporter-2 -LRB- hENT2 -RRB- protein expression correlates with ex vivo sensitivity to fludarabine in chronic_lymphocytic_leukemia -LRB- CLL -RRB- cells .
19297449	0	nucleoside	109,119	hENT2	140,145	nucleoside	hENT2	CHEBI:33838	3177	Chemical	Gene	transporters|amod|START_ENTITY roles|nmod|transporters roles|dep|hENT1 hENT1|nummod|END_ENTITY	Transepithelial fluxes of adenosine and 2 ' - deoxyadenosine across human renal proximal tubule cells : roles of nucleoside transporters hENT1 , hENT2 , and hCNT3 .
15701636	0	nucleoside	67,77	hENT3	92,97	nucleoside	hENT3	CHEBI:33838	55315	Chemical	Gene	transporters|compound|START_ENTITY transporters|dep|END_ENTITY	Functional characterization of novel human and mouse equilibrative nucleoside transporters -LRB- hENT3 and mENT3 -RRB- located in intracellular membranes .
20595384	0	nucleoside	20,30	hENT3	46,51	nucleoside	hENT3	CHEBI:33838	55315	Chemical	Gene	mutations|amod|START_ENTITY mutations|appos|END_ENTITY	Human equilibrative nucleoside transporter-3 -LRB- hENT3 -RRB- spectrum disorder mutations impair nucleoside transport , protein localization , and stability .
20595384	0	nucleoside	88,98	hENT3	46,51	nucleoside	hENT3	CHEBI:33838	55315	Chemical	Gene	transport|compound|START_ENTITY mutations|dep|transport mutations|appos|END_ENTITY	Human equilibrative nucleoside transporter-3 -LRB- hENT3 -RRB- spectrum disorder mutations impair nucleoside transport , protein localization , and stability .
22653152	0	nucleoside	75,85	hENT3	186,191	nucleoside	hENT3	CHEBI:33838	55315	Chemical	Gene	transporter|amod|START_ENTITY encoding|dobj|transporter Identification|acl|encoding Identification|dep|studies studies|nmod|SLC29A3 SLC29A3|appos|END_ENTITY	Identification of two novel mutations in SLC29A3 encoding an equilibrative nucleoside transporter -LRB- hENT3 -RRB- in two distinct Syrian families with H_syndrome : expression studies of SLC29A3 -LRB- hENT3 -RRB- in human skin .
22653152	0	nucleoside	75,85	hENT3	99,104	nucleoside	hENT3	CHEBI:33838	55315	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Identification of two novel mutations in SLC29A3 encoding an equilibrative nucleoside transporter -LRB- hENT3 -RRB- in two distinct Syrian families with H_syndrome : expression studies of SLC29A3 -LRB- hENT3 -RRB- in human skin .
10336543	0	nucleoside	71,81	hSPNT1	95,101	nucleoside	hSPNT1	CHEBI:33838	9153	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Functional characterization of a human purine-selective , Na + - dependent nucleoside transporter -LRB- hSPNT1 -RRB- in a mammalian expression system .
11814344	1	nucleoside	187,197	human	167,172	nucleoside	hENT1	CHEBI:33838	2030	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	The human equilibrative nucleoside transporter , hENT1 , which is sensitive to inhibition by nitrobenzylthioinosine -LRB- NBMPR -RRB- , is expressed in a wide variety of tissues .
18621735	1	nucleoside	135,145	human	224,229	nucleoside	hCNT3	CHEBI:33838	64078	Chemical	Gene	transporter|compound|START_ENTITY humans|appos|transporter represented|nmod|humans represented|parataxis|pyrimidine pyrimidine|nsubj|CNT1 CNT1|amod|END_ENTITY	In humans , the SLC28 concentrative nucleoside transporter -LRB- CNT -RRB- protein family is represented by three Na + - coupled members ; human CNT1 -LRB- hCNT1 -RRB- and hCNT2 are pyrimidine and purine nucleoside-selective , respectively , whereas hCNT3 transports both purine and pyrimidine_nucleosides and nucleoside drugs .
10950861	0	nucleoside	79,89	rCNT1	103,108	nucleoside	rCNT1	CHEBI:33838	116642(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Electrophysiological analysis of the substrate selectivity of a sodium-coupled nucleoside transporter -LRB- rCNT1 -RRB- expressed in Xenopus_laevis oocytes .
12441131	0	nucleoside	14,24	rCNT1	38,43	nucleoside	rCNT1	CHEBI:33838	116642(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Concentrative nucleoside transporter -LRB- rCNT1 -RRB- is targeted to the apical membrane through the hepatic transcytotic pathway .
15626578	0	nucleoside	89,99	rENT1	83,88	nucleoside	rENT1	CHEBI:33838	63997(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	Brain penetration of synthetic adenosine A1 receptor agonists in situ : role of the rENT1 nucleoside transporter and binding to blood constituents .
9353301	0	nucleoside	140,150	rENT1	173,178	nucleoside	rENT1	CHEBI:33838	63997(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|proteins proteins|dep|END_ENTITY	Molecular cloning and functional characterization of nitrobenzylthioinosine -LRB- NBMPR -RRB- - sensitive -LRB- es -RRB- and NBMPR-insensitive -LRB- ei -RRB- equilibrative nucleoside transporter proteins -LRB- rENT1 and rENT2 -RRB- from rat tissues .
4096893	0	nucleoside_dialdehydes	8,30	S-adenosylhomocysteine_hydrolase	66,98	nucleoside dialdehydes	S-adenosylhomocysteine hydrolase	null	508158(Tax:9913)	Chemical	Gene	START_ENTITY|dep|inhibitors inhibitors|nmod|END_ENTITY	Adenine nucleoside_dialdehydes : potent inhibitors of bovine liver S-adenosylhomocysteine_hydrolase .
10837140	0	nucleoside_diphosphate	4,26	DRnm23	46,52	nucleoside diphosphate	DRnm23	CHEBI:16862	4832	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	The nucleoside_diphosphate kinase activity of DRnm23 is not required for inhibition of differentiation and induction of apoptosis in 32Dcl3 myeloid precursor cells .
25224398	0	nucleoside_diphosphate	108,130	NDPK-3	139,145	nucleoside diphosphate	NDPK-3	CHEBI:16862	826702(Tax:3702)	Chemical	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	Stress signaling in response to polycyclic aromatic hydrocarbon exposure in Arabidopsis_thaliana involves a nucleoside_diphosphate kinase , NDPK-3 .
20934113	0	nucleoside_diphosphate	15,37	nm23	46,50	nucleoside diphosphate	nm23	CHEBI:16862	4830	Chemical	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	Expressions of nucleoside_diphosphate kinase -LRB- nm23 -RRB- in tumor tissues are related with metastasis and length of survival of patients with hepatocellular_carcinoma .
8392752	0	nucleoside_diphosphate	59,81	nm23-H2	51,58	nucleoside diphosphate	nm23-H2	CHEBI:16862	4831	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Human c-myc transcription factor PuF identified as nm23-H2 nucleoside_diphosphate kinase , a candidate suppressor of tumor metastasis .
10799505	0	nucleoside_diphosphate	50,72	nm23-H4	10,17	nucleoside diphosphate	nm23-H4	CHEBI:16862	4833	Chemical	Gene	kinase|compound|START_ENTITY kinase|nsubj|product product|amod|END_ENTITY	The human nm23-H4 gene product is a mitochondrial nucleoside_diphosphate kinase .
9726996	0	nucleoside_diphosphates	86,109	ATPase	15,21	nucleoside diphosphates	ATPase	CHEBI:16862	1769	Chemical	Gene	Stimulation|nmod|START_ENTITY Stimulation|nmod|activity activity|compound|END_ENTITY	Stimulation of ATPase activity of purified multidrug_resistance-associated_protein by nucleoside_diphosphates .
9726996	0	nucleoside_diphosphates	86,109	multidrug_resistance-associated_protein	43,82	nucleoside diphosphates	multidrug resistance-associated protein	CHEBI:16862	8714	Chemical	Gene	Stimulation|nmod|START_ENTITY Stimulation|nmod|END_ENTITY	Stimulation of ATPase activity of purified multidrug_resistance-associated_protein by nucleoside_diphosphates .
18058530	0	nucleoside_phosphonates	32,55	thymidine_phosphorylase	80,103	nucleoside phosphonates	thymidine phosphorylase	null	1890	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Syntheses of pyrimidine acyclic nucleoside_phosphonates as potent inhibitors of thymidine_phosphorylase -LRB- PD-ECGF -RRB- from SD-lymphoma .
8226942	0	nucleoside_triphosphate	73,96	recA	45,49	nucleoside triphosphate	recA	CHEBI:17326	5888	Chemical	Gene	protein|nmod|START_ENTITY protein|compound|END_ENTITY	Activation of a recombinase-deficient mutant recA protein with alternate nucleoside_triphosphate cofactors .
6069133	0	nucleoside_triphosphates	85,109	adenine_phosphoribosyltransferase	15,48	nucleoside triphosphates	adenine phosphoribosyltransferase	CHEBI:17326	353	Chemical	Gene	Stimulation|nmod|START_ENTITY Stimulation|nmod|END_ENTITY	Stimulation of adenine_phosphoribosyltransferase by adenosine_triphosphate and other nucleoside_triphosphates .
8374056	2	nucleosides	497,508	DBP	474,477	nucleosides	DBP	MESH:D009705	1628	Chemical	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	Electrochemical oxidation of DBP in the presence of nucleosides leads to adducts from DBP .
10996312	0	nucleosides	23,34	hCNT1	103,108	nucleosides	hCNT1	MESH:D009705	9154	Chemical	Gene	uptake|nmod|START_ENTITY uptake|nmod|END_ENTITY	Electrogenic uptake of nucleosides and nucleoside-derived drugs by the human nucleoside transporter 1 -LRB- hCNT1 -RRB- expressed in Xenopus_laevis oocytes .
16964555	0	nucleotide	53,63	A20	99,102	nucleotide	A20	CHEBI:36976	28935	Chemical	Gene	sequence|compound|START_ENTITY sequence|nmod|END_ENTITY	Identification , phenotypic analysis , and full-length nucleotide sequence of a Dutch Coxsackievirus A20 isolate .
16815813	0	nucleotide	66,76	ABCB1	100,105	nucleotide	ABCB1	CHEBI:36976	5243	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Structure , function , expression , genomic organization , and single nucleotide polymorphisms of human ABCB1 -LRB- MDR1 -RRB- , ABCC -LRB- MRP -RRB- , and ABCG2 -LRB- BCRP -RRB- efflux transporters .
25637052	0	nucleotide	7,17	ABCB1	35,40	nucleotide	ABCB1	CHEBI:36976	5243	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Single nucleotide polymorphisms in ABCB1 and CBR1 can predict toxicity to R-CHOP type regimens in patients with diffuse_non_Hodgkin_lymphoma .
19101985	0	nucleotide	30,40	ABCB11	58,64	nucleotide	ABCB11	CHEBI:36976	8647	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Missense mutations and single nucleotide polymorphisms in ABCB11 impair bile_salt export pump processing and function or disrupt pre-messenger RNA splicing .
25078270	0	nucleotide	28,38	ABCC1	59,64	nucleotide	ABCC1	CHEBI:36976	4363	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|gene gene|compound|END_ENTITY	Non-coding polymorphisms in nucleotide binding domain 1 in ABCC1 gene associate with transcript level and survival of patients with breast_cancer .
22955427	0	nucleotide	7,17	ABCC2	35,40	nucleotide	ABCC2	CHEBI:36976	1244	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Single nucleotide polymorphisms in ABCC2 associate with tenofovir-induced kidney_tubular_dysfunction in Japanese patients with HIV-1_infection : a pharmacogenetic study .
15861033	0	nucleotide	37,47	ABCC5	69,74	nucleotide	ABCC5	CHEBI:36976	10057	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Strong linkage disequilibrium at the nucleotide analogue transporter ABCC5 gene locus .
21892003	0	nucleotide	7,17	ABCC5	35,40	nucleotide	ABCC5	CHEBI:36976	10057	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|genes genes|compound|END_ENTITY	Single nucleotide polymorphisms of ABCC5 and ABCG1 transporter genes correlate to irinotecan-associated gastrointestinal_toxicity in colorectal_cancer patients : a DMET microarray profiling study .
17584938	0	nucleotide	41,51	ABCG2	59,64	nucleotide	ABCG2	CHEBI:36976	536203(Tax:9913)	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Genetic support for a quantitative trait nucleotide in the ABCG2 gene affecting milk composition of dairy cattle .
17827468	0	nucleotide	7,17	ABCG5	35,40	nucleotide	ABCG5	CHEBI:36976	64240	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Single nucleotide polymorphisms in ABCG5 and ABCG8 are associated with changes in cholesterol metabolism during weight loss .
11123914	0	nucleotide	15,25	ABCR	62,66	nucleotide	ABCR	CHEBI:36976	24	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|protein protein|compound|END_ENTITY	The C-terminal nucleotide binding domain of the human retinal ABCR protein is an adenosine triphosphatase .
24669260	0	nucleotide	27,37	ACTA2	59,64	nucleotide	ACTA2	CHEBI:36976	59	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Correlation between single nucleotide polymorphisms of the ACTA2 gene and coronary_artery_stenosis in patients with type_2_diabetes_mellitus .
17077940	0	nucleotide	15,25	ACVR1	42,47	nucleotide	ACVR1	CHEBI:36976	90	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	De novo 617G-A nucleotide mutation in the ACVR1 gene in a Taiwanese patient with fibrodysplasia ossificans progressiva .
20112867	4	nucleotide	573,583	AChE	598,602	nucleotide	AChE	CHEBI:36976	43	Chemical	Gene	identity|amod|START_ENTITY identity|nmod|END_ENTITY	The amplified fragment of 966 nucleotides generated by PCR was cloned , and sequence analysis showed 82 % nucleotide identity with AChE of the Electrophorus electricus .
6376509	0	nucleotide	10,20	ADE4	58,62	nucleotide	ADE4	CHEBI:36976	855346(Tax:4932)	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Glutamine nucleotide sequence of Saccharomyces_cerevisiae ADE4 encoding phosphoribosylpyrophosphate amidotransferase .
20032495	0	nucleotide	61,71	ADIPOQ	89,95	nucleotide	ADIPOQ	CHEBI:36976	9370	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Gene-nutrient interactions in the metabolic_syndrome : single nucleotide polymorphisms in ADIPOQ and ADIPOR1 interact with plasma saturated fatty_acids to modulate insulin resistance .
7836400	0	nucleotide	56,66	ADP-ribosylation_factor_1	18,43	nucleotide	ADP-ribosylation factor 1	CHEBI:36976	338058(Tax:9913)	Chemical	Gene	exchange|amod|START_ENTITY facilitates|dobj|exchange facilitates|nsubj|Myristoylation Myristoylation|nmod|END_ENTITY	Myristoylation of ADP-ribosylation_factor_1 facilitates nucleotide exchange at physiological Mg2 + levels .
7961749	0	nucleotide	33,43	ADP-ribosylation_factor_1	67,92	nucleotide	ADP-ribosylation factor 1	CHEBI:36976	375	Chemical	Gene	properties|amod|START_ENTITY properties|nmod|END_ENTITY	Effects of acid phospholipids on nucleotide exchange properties of ADP-ribosylation_factor_1 .
26615960	0	nucleotide	7,17	AGTR1	35,40	nucleotide	AGTR1	D009711	185	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Single nucleotide polymorphisms in AGTR1 , TFAP2B , and TRAF1 are not associated with the incidence of patent_ductus_arteriosus in Japanese preterm infants .
21217827	0	nucleotide	16,26	AKR1C1	54,60	nucleotide	AKR1C1	CHEBI:36976	1645	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Modeling single nucleotide polymorphisms in the human AKR1C1 and AKR1C2 genes : implications for functional and genotyping analyses .
17952709	0	nucleotide	7,17	ALDH2	39,44	nucleotide	ALDH2	CHEBI:36976	217	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Single nucleotide polymorphisms of the ALDH2 gene in six Indian populations .
20676957	0	nucleotide	11,21	ALOX15	39,45	nucleotide	ALOX15	CHEBI:36976	246	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Two single nucleotide polymorphisms in ALOX15 are associated with risk of coronary_artery_disease in a Chinese Han population .
18698520	0	nucleotide	7,17	ANKK1	35,40	nucleotide	ANKK1	CHEBI:36976	255239	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Single nucleotide polymorphisms in ANKK1 and the dopamine_D2_receptor gene affect cognitive outcome shortly after traumatic_brain_injury : a replication and extension study .
16569251	0	nucleotide	7,17	APC	39,42	nucleotide	APC	CHEBI:36976	324	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Single nucleotide polymorphisms of the APC gene and colorectal_cancer risk : a case-control study in Taiwan .
23656756	0	nucleotide	7,17	APOA5	72,77	nucleotide	APOA5	CHEBI:36976	116519	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Single nucleotide polymorphisms in CETP , SLC46A1 , SLC19A1 , CD36 , BCMO1 , APOA5 , and ABCA1 are significant predictors of plasma HDL in healthy adults .
25203737	0	nucleotide	7,17	AREG	35,39	nucleotide	AREG	CHEBI:36976	374	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Single nucleotide polymorphisms in AREG and EREG are prognostic biomarkers in locally advanced gastric_cancer patients after surgery with curative intent .
6386606	0	nucleotide	4,14	ARG4	37,41	nucleotide	ARG4	CHEBI:36976	856411(Tax:4932)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|gene gene|compound|END_ENTITY	The nucleotide sequence of the yeast ARG4 gene .
10531036	0	nucleotide	19,29	ARNO	14,18	nucleotide	ARNO	CHEBI:36976	9266	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of ARNO nucleotide exchange by a PH domain electrostatic switch .
21828933	0	nucleotide	7,17	ARNT	93,97	nucleotide	ARNT	CHEBI:36976	405	Chemical	Gene	START_ENTITY|dobj|gene gene|appos|END_ENTITY	Single nucleotide polymorphisms in the human aryl_hydrocarbon_receptor nuclear translocator -LRB- ARNT -RRB- gene .
25286669	0	nucleotide	7,17	ARSD	60,64	nucleotide	ARSD	CHEBI:36976	414	Chemical	Gene	polymorphism|compound|START_ENTITY polymorphism|appos|END_ENTITY	Single nucleotide polymorphism within arylsulfatase_D gene -LRB- ARSD -RRB- is associated with selected kinematic parameters of sperm motility in Holstein-Friesian bulls .
22537351	0	nucleotide	22,32	ATM	60,63	nucleotide	ATM	CHEBI:36976	472	Chemical	Gene	Association|nmod|START_ENTITY polymorphisms|nsubj|Association polymorphisms|nmod|END_ENTITY	Association of single nucleotide polymorphisms in the genes ATM , GSTP1 , SOD2 , TGFB1 , XPD and XRCC1 with risk of severe erythema after breast conserving radiotherapy .
1427863	0	nucleotide	21,31	ATP2B2	77,83	nucleotide	ATP2B2	CHEBI:36976	491	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|gene gene|compound|END_ENTITY	Determination of the nucleotide sequence and chromosomal localization of the ATP2B2 gene encoding human Ca -LRB- 2 + -RRB- - pumping ATPase isoform PMCA2 .
127088	0	nucleotide	42,52	ATPase	75,81	nucleotide	ATPase	CHEBI:36976	9742434	Chemical	Gene	Studies|nmod|START_ENTITY Studies|nmod|END_ENTITY	Studies of substructure and tightly bound nucleotide in bacterial membrane ATPase .
1707673	4	nucleotide	619,629	ATPase	652,658	nucleotide	ATPase	CHEBI:36976	1769	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	The experiments suggest considerable exposure of the nucleotide binding domain of the ATPase on the top surface of the protein .
9390185	0	nucleotide	63,73	ATPase	56,62	nucleotide	ATPase	CHEBI:36976	1769	Chemical	Gene	domain|compound|START_ENTITY domain|amod|END_ENTITY	Structural changes of the sarcoplasmic reticulum Ca -LRB- II -RRB- - ATPase nucleotide binding domain by pH and La -LRB- III -RRB- .
2893758	0	nucleotide	51,61	Adh-1	78,83	nucleotide	Adh-1	CHEBI:36976	11522(Tax:10090)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|gene gene|compound|END_ENTITY	Molecular analysis of mouse alcohol_dehydrogenase : nucleotide sequence of the Adh-1 gene and genetic mapping of a related nucleotide sequence to chromosome 3 .
26387083	0	nucleotide	47,57	Apolipoprotein_A5	0,17	nucleotide	Apolipoprotein A5	D009711	116519	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|compound|END_ENTITY	Apolipoprotein_A5 and apolipoprotein_C3 single nucleotide polymorphisms are correlated with an increased risk of coronary_heart_disease : a case-control and meta-analysis study .
22883453	0	nucleotide	28,38	BARD_1	56,62	nucleotide	BARD 1	CHEBI:36976	580	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	-LSB- Association between single nucleotide polymorphisms of BARD_1 gene and susceptibility of early-onset breast_cancer in Uygur women in Xinjiang -RSB- .
20529763	0	nucleotide	135,145	BCHE	163,167	nucleotide	BCHE	CHEBI:36976	590	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Evaluation of candidate genes for cholinesterase activity in farmworkers exposed to organophosphorus pesticides : association of single nucleotide polymorphisms in BCHE .
17039264	0	nucleotide	15,25	BRCA1	58,63	nucleotide	BRCA1	CHEBI:36976	672	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Role of single nucleotide polymorphisms and haplotypes in BRCA1 in breast_cancer : Czech case-control study .
12356756	0	nucleotide	46,56	BiP	111,114	nucleotide	BiP	CHEBI:36976	3309	Chemical	Gene	factor|amod|START_ENTITY factor|acl:relcl|regulates regulates|dobj|activity activity|nmod|END_ENTITY	BAP , a mammalian BiP-associated_protein , is a nucleotide exchange factor that regulates the ATPase activity of BiP .
25473114	0	nucleotide	8,18	BiP	39,42	nucleotide	BiP	CHEBI:36976	14828(Tax:10090)	Chemical	Gene	factor|amod|START_ENTITY factor|nmod|END_ENTITY	Sil1 , a nucleotide exchange factor for BiP , is not required for antibody assembly or secretion .
25877869	0	nucleotide	4,14	BiP	82,85	nucleotide	BiP	D009711	3309	Chemical	Gene	exchange|nsubj|START_ENTITY exchange|ccomp|induce induce|dobj|release release|nmod|END_ENTITY	The nucleotide exchange factors Grp170 and Sil1 induce cholera toxin release from BiP to enable retro-translocation .
25877869	0	nucleotide	4,14	BiP	82,85	nucleotide	BiP	D009711	3309	Chemical	Gene	exchange|nsubj|START_ENTITY exchange|ccomp|induce induce|dobj|release release|nmod|END_ENTITY	The nucleotide exchange factors Grp170 and Sil1 induce cholera toxin release from BiP to enable retro-translocation .
7592893	0	nucleotide	24,34	BiP	97,100	nucleotide	BiP	CHEBI:36976	3309	Chemical	Gene	properties|amod|START_ENTITY properties|nmod|END_ENTITY	Characterization of the nucleotide binding properties and ATPase activity of recombinant hamster BiP purified from bacteria .
19429006	0	nucleotide	28,38	CACNA1A	60,67	nucleotide	CACNA1A	CHEBI:36976	773	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	The interplay of two single nucleotide polymorphisms in the CACNA1A gene may contribute to migraine susceptibility .
3327612	0	nucleotide	25,35	CAN1	52,56	nucleotide	CAN1	CHEBI:36976	856646(Tax:4932)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|gene gene|compound|END_ENTITY	Yeast arginine permease : nucleotide sequence of the CAN1 gene .
21968622	0	nucleotide	7,17	CAPN	35,39	nucleotide	CAPN	CHEBI:36976	100885279	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|genes genes|compound|END_ENTITY	Single nucleotide polymorphisms in CAPN and leptin genes associated with meat color and tenderness in Nellore cattle .
26946475	0	nucleotide	22,32	CAPN1	50,55	nucleotide	CAPN1	D009711	281661(Tax:9913)	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Association of single nucleotide polymorphisms in CAPN1 , CAST and MB genes with meat color of Brahman and crossbreed cattle .
18385174	0	nucleotide	18,28	CCL5	50,54	nucleotide	CCL5	CHEBI:36976	6352	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Functional single nucleotide polymorphisms of the CCL5 gene and nonemphysematous phenotype in COPD patients .
22095474	0	nucleotide	25,35	CCNA2	57,62	nucleotide	CCNA2	CHEBI:36976	100134866(Tax:9986)	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Identification of single nucleotide polymorphisms in the CCNA2 gene and its association with wool density in Rex rabbits .
20437071	0	nucleotide	7,17	CD244	35,40	nucleotide	CD244	CHEBI:36976	51744	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Single nucleotide polymorphisms of CD244 gene predispose to renal and neuropsychiatric manifestations with systemic_lupus_erythematosus .
22366648	0	nucleotide	105,115	CD38	133,137	nucleotide	CD38	CHEBI:36976	12494(Tax:10090)	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Social memory , amnesia , and autism : brain oxytocin secretion is regulated by NAD + metabolites and single nucleotide polymorphisms of CD38 .
25376343	0	nucleotide	25,35	CD8	6,9	nucleotide	CD8	CHEBI:36976	925	Chemical	Gene	composition|compound|START_ENTITY composition|compound|END_ENTITY	Viral CD8 T cell epitope nucleotide composition shows evidence of short - and long-term evolutionary strategies .
8671674	0	nucleotide	18,28	CDR1	13,17	nucleotide	CDR1	CHEBI:36976	1038	Chemical	Gene	sequences|compound|START_ENTITY sequences|compound|END_ENTITY	Canonical VH CDR1 nucleotide sequences are conserved in all jawed vertebrates .
23362846	0	nucleotide	22,32	CFH	50,53	nucleotide	CFH	CHEBI:36976	3075	Chemical	Gene	Association|nmod|START_ENTITY polymorphisms|nsubj|Association polymorphisms|nmod|END_ENTITY	Association of single nucleotide polymorphisms in CFH , ARMS2 and HTRA1 genes with risk of age-related macular_degeneration in Egyptian patients .
24273577	0	nucleotide	48,58	COL1A1	76,82	nucleotide	COL1A1	CHEBI:36976	1277	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Evaluation and identification of damaged single nucleotide polymorphisms in COL1A1 gene involved in osteoporosis .
21993774	0	nucleotide	42,52	COL2A1	74,80	nucleotide	COL2A1	CHEBI:36976	1280	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	High_myopia is not associated with single nucleotide polymorphisms in the COL2A1 gene in the Chinese population .
24008922	0	nucleotide	20,30	COMT	48,52	nucleotide	COMT	D009711	1312	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Influence of single nucleotide polymorphisms in COMT , MAO-A and BDNF genes on dyskinesias and levodopa use in Parkinson 's _ disease .
22833659	0	nucleotide	18,28	CRBP2	67,72	nucleotide	CRBP2	CHEBI:36976	5948	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Gender and single nucleotide polymorphisms in MTHFR , BHMT , SPTLC1 , CRBP2 , CETP , and SCARB1 are significant predictors of plasma homocysteine normalized by RBC folate in healthy adults .
26085818	0	nucleotide	7,17	CRTC1	35,40	nucleotide	CRTC1	D009711	23373	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Single nucleotide polymorphisms in CRTC1 and BARX1 are associated with esophageal_adenocarcinoma .
17016057	0	nucleotide	36,46	CRTH2	138,143	nucleotide	CRTH2	CHEBI:36976	11251	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|appos|END_ENTITY	Genetic impact of functional single nucleotide polymorphisms in the 3 ' - UTR region of the chemoattractant receptor expressed on Th2 cells -LRB- CRTH2 -RRB- gene on asthma and atopy in a Japanese population .
15785242	0	nucleotide	12,22	CT60	0,4	nucleotide	CT60	CHEBI:36976	348120	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nummod|END_ENTITY	CT60 single nucleotide polymorphisms of the cytotoxic_T-lymphocyte-associated_antigen-4 gene region is associated with Graves ' _ disease in an Italian population .
23979897	0	nucleotide	28,38	CXCR1	60,65	nucleotide	CXCR1	CHEBI:36976	281863(Tax:9913)	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Association of novel single nucleotide polymorphisms of the CXCR1 gene with the milk performance traits of Chinese native cattle .
15129369	0	nucleotide	11,21	CYP17	43,48	nucleotide	CYP17	CHEBI:36976	1586	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|Genes Genes|compound|END_ENTITY	Two single nucleotide polymorphisms in the CYP17 and COMT Genes -- relation to bone mass and longitudinal bone changes in postmenopausal women with or without hormone replacement therapy .
21442439	0	nucleotide	7,17	CYP19A1	35,42	nucleotide	CYP19A1	CHEBI:36976	1588	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Single nucleotide polymorphisms of CYP19A1 predict clinical outcomes and adverse events associated with letrozole in patients with metastatic_breast_cancer .
15770072	0	nucleotide	7,17	CYP1A2	50,56	nucleotide	CYP1A2	CHEBI:36976	1544	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Single nucleotide polymorphisms and haplotypes of CYP1A2 in a Japanese population .
19583676	0	nucleotide	86,96	CYP1A2	122,128	nucleotide	CYP1A2	CHEBI:36976	1544	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Comparison of linkage disequilibrium patterns and haplotype structure of eight single nucleotide polymorphisms across the CYP1A2 gene between the Korean , and other populations registered in the International HapMap database .
22141270	0	nucleotide	8,18	CYP1A2	36,42	nucleotide	CYP1A2	CHEBI:36976	1544	Chemical	Gene	START_ENTITY|dobj|polymorphisms polymorphisms|nmod|END_ENTITY	-LSB- Single nucleotide polymorphisms of CYP1A2 and their correlation with prostate_cancer -RSB- .
9518489	0	nucleotide	10,20	CYP21	34,39	nucleotide	CYP21	CHEBI:36976	1589	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	The -104 G nucleotide of the human CYP21 gene is important for CYP21 transcription activity and protein interaction .
20801498	0	nucleotide	35,45	CYP2C19	10,17	nucleotide	CYP2C19	D009711	1557	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|compound|END_ENTITY	Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute_coronary_syndromes : a genetic substudy of the PLATO trial .
21325430	0	nucleotide	53,63	CYP2C19	81,88	nucleotide	CYP2C19	CHEBI:36976	1557	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Evaluation of the effects of 20 nonsynonymous single nucleotide polymorphisms of CYP2C19 on S-mephenytoin 4 ' - hydroxylation and omeprazole 5 ' - hydroxylation .
15618699	0	nucleotide	13,23	CYP2D6	45,51	nucleotide	CYP2D6	CHEBI:36976	1565	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Novel single nucleotide polymorphisms in the CYP2D6 gene associated with CYP2D6 * 2 and/or CYP2D6 * 10 alleles .
16207150	0	nucleotide	23,33	CYP3A	10,15	nucleotide	CYP3A	CHEBI:36976	1576	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nummod|END_ENTITY	Screening CYP3A single nucleotide polymorphisms in a Han Chinese population with a genotyping chip .
12893984	0	nucleotide	63,73	CYP3A5	49,55	nucleotide	CYP3A5	CHEBI:36976	1577	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|compound|END_ENTITY	Genetic findings and functional studies of human CYP3A5 single nucleotide polymorphisms in different ethnic groups .
16701601	2	nucleotide	173,183	CYP3A5	205,211	nucleotide	CYP3A5	CHEBI:36976	1577	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Single nucleotide polymorphisms in the CYP3A5 gene -LRB- CYP3A5 -LRB- * -RRB- 3C and CYP3A5 -LRB- * -RRB- 6 -RRB- are associated with decreased CYP3A5 expression in the liver .
2844186	4	nucleotide	610,620	CaM	589,592	nucleotide	CaM	CHEBI:36976	808	Chemical	Gene	phosphodiesterase|compound|START_ENTITY phosphodiesterase|compound|END_ENTITY	On the other hand , the concentration of CV-159 producing 50 % inhibition of Ca2 + / CaM activated cyclic nucleotide phosphodiesterase -LRB- Ca2 + - PDE -RRB- was 0.55 microM .
19356586	0	nucleotide	115,125	Cdc42	139,144	nucleotide	Cdc42	CHEBI:36976	998	Chemical	Gene	release|compound|START_ENTITY release|nmod|END_ENTITY	Characterisation of the nucleotide exchange factor ITSN1L : evidence for a kinetic discrimination of GEF-stimulated nucleotide release from Cdc42 .
15850398	0	nucleotide	42,52	Cdr1p	108,113	nucleotide	Cdr1p	CHEBI:36976	1038	Chemical	Gene	START_ENTITY|dobj|domain domain|nmod|END_ENTITY	Functional characterization of N-terminal nucleotide binding domain -LRB- NBD-1 -RRB- of a major ABC drug transporter Cdr1p of Candida_albicans : uncommon but conserved Trp326 of Walker B is important for ATP binding .
15809298	0	nucleotide	15,25	ClpB	55,59	nucleotide	ClpB	CHEBI:36976	81570	Chemical	Gene	START_ENTITY|dobj|domain domain|nmod|chaperone chaperone|compound|END_ENTITY	ATP binding to nucleotide binding domain -LRB- NBD -RRB- 1 of the ClpB chaperone induces motion of the long coiled-coil , stabilizes the hexamer , and activates NBD2 .
19177562	0	nucleotide	27,37	ClpB	95,99	nucleotide	ClpB	CHEBI:36976	81570	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	Walker-A threonine couples nucleotide occupancy with the chaperone activity of the AAA + ATPase ClpB .
24531492	0	nucleotide	12,22	ClpB	81,85	nucleotide	ClpB	CHEBI:36976	81570	Chemical	Gene	sensing|amod|START_ENTITY sensing|nmod|END_ENTITY	Elements in nucleotide sensing and hydrolysis of the AAA + disaggregation machine ClpB : a structure-based mechanistic dissection of a molecular motor .
17343982	5	nucleotide	647,657	Cx43	632,636	nucleotide	Cx43	CHEBI:36976	2697	Chemical	Gene	treatment|compound|START_ENTITY treatment|amod|END_ENTITY	This negative growth control by BBI was abrogated under down-regulation of Cx43 induced by a Cx43 antisense nucleotide treatment .
7518829	0	nucleotide	75,85	Cystic_fibrosis_transmembrane_conductance_regulator	0,51	nucleotide	Cystic fibrosis transmembrane conductance regulator	CHEBI:36976	1080	Chemical	Gene	START_ENTITY|nsubj|mutations mutations|amod|END_ENTITY	Cystic_fibrosis_transmembrane_conductance_regulator mutations that disrupt nucleotide binding .
26442298	0	nucleotide	24,34	DAZL	56,60	nucleotide	DAZL	D009711	1618	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	-LSB- A260G and A386G single nucleotide polymorphisms of the DAZL gene are not correlated with male_infertility in the Chinese population of Zhejiang Province -RSB- .
8349582	0	nucleotide	73,83	DBL	69,72	nucleotide	DBL	CHEBI:36976	4168	Chemical	Gene	domain|amod|START_ENTITY domain|compound|END_ENTITY	Human ABR encodes a protein with GAPrac activity and homology to the DBL nucleotide exchange factor domain .
26689513	0	nucleotide	7,17	DKK3	35,39	nucleotide	DKK3	D009711	27122	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Single nucleotide polymorphisms in DKK3 gene are associated with prostate_cancer risk and progression .
18812394	0	nucleotide	31,41	DNASE2	17,23	nucleotide	DNASE2	CHEBI:36976	1777	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nummod|END_ENTITY	Homozygosity for DNASE2 single nucleotide polymorphisms in the 5 ' - regulatory region is associated with rheumatoid_arthritis .
12962495	0	nucleotide	83,93	DNA_polymerase_Beta	12,31	nucleotide	DNA polymerase Beta	CHEBI:36976	5423	Chemical	Gene	substrate|amod|START_ENTITY affinity|nmod|substrate due|nmod|affinity extend|xcomp|due extend|nsubj|Variants Variants|nmod|END_ENTITY	Variants of DNA_polymerase_Beta extend mispaired DNA due to increased affinity for nucleotide substrate .
11024043	0	nucleotide	42,52	DNA_polymerase_beta	70,89	nucleotide	DNA polymerase beta	CHEBI:36976	5423	Chemical	Gene	START_ENTITY|xcomp|binding binding|nmod|END_ENTITY	DNA structure and aspartate 276 influence nucleotide binding to human DNA_polymerase_beta .
11560485	0	nucleotide	50,60	DNA_polymerase_beta	2,21	nucleotide	DNA polymerase beta	CHEBI:36976	5423	Chemical	Gene	discrimination|amod|START_ENTITY mutant|nmod|discrimination mutant|nsubj|mutator mutator|compound|END_ENTITY	A DNA_polymerase_beta mutator mutant with reduced nucleotide discrimination and increased protein stability .
16042415	0	nucleotide	117,127	DNA_polymerase_beta	10,29	nucleotide	DNA polymerase beta	CHEBI:36976	5423	Chemical	Gene	present|nmod|START_ENTITY present|nsubj|Effect Effect|nmod|variants variants|compound|END_ENTITY	Effect of DNA_polymerase_beta loop variants on discrimination of O6-methyldeoxyguanosine modification present in the nucleotide versus template substrate .
16842743	0	nucleotide	13,23	DNA_polymerase_beta	41,60	nucleotide	DNA polymerase beta	CHEBI:36976	5423	Chemical	Gene	incorporation|amod|START_ENTITY Mechanism|nmod|incorporation Mechanism|nmod|END_ENTITY	Mechanism of nucleotide incorporation in DNA_polymerase_beta .
18391201	0	nucleotide	10,20	DNA_polymerase_beta	81,100	nucleotide	DNA polymerase beta	D009711	5423	Chemical	Gene	insertion|compound|START_ENTITY insertion|dep|mismatch mismatch|acl|catalyzed catalyzed|nmod|END_ENTITY	Incorrect nucleotide insertion at the active site of a G : A mismatch catalyzed by DNA_polymerase_beta .
8647805	0	nucleotide	47,57	DNA_polymerase_beta	100,119	nucleotide	DNA polymerase beta	CHEBI:36976	5423	Chemical	Gene	incorporation|amod|START_ENTITY required|nmod|incorporation required|nmod|END_ENTITY	Enzyme-DNA interactions required for efficient nucleotide incorporation and discrimination in human DNA_polymerase_beta .
8999973	1	nucleotide	90,100	DNA_polymerase_beta	124,143	nucleotide	DNA polymerase beta	CHEBI:36976	5423	Chemical	Gene	types|nmod|START_ENTITY incorporation|nsubj|types incorporation|nmod|END_ENTITY	Novel types of nucleotide incorporation by human DNA_polymerase_beta at an abasic lesion in different sequence contexts .
21498394	0	nucleotide	28,38	DPYD	71,75	nucleotide	DPYD	CHEBI:36976	1806	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Relationship between single nucleotide polymorphisms and haplotypes in DPYD and toxicity and efficacy of capecitabine in advanced colorectal_cancer .
25760541	0	nucleotide	13,23	DPYS	71,75	nucleotide	DPYS	CHEBI:36976	1807	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|appos|END_ENTITY	Novel single nucleotide polymorphisms of the dihydropyrimidinase gene -LRB- DPYS -RRB- in Japanese individuals .
2134154	0	nucleotide	4,14	DQB	47,50	nucleotide	DQB	CHEBI:36976	539241(Tax:9913)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The nucleotide sequence of bovine MHC class II DQB and DRB genes .
20219341	0	nucleotide	78,88	Duchenne_muscular_dystrophy	101,128	nucleotide	Duchenne muscular dystrophy	CHEBI:36976	1756	Chemical	Gene	mutation|compound|START_ENTITY mutation|nmod|END_ENTITY	Dimeric gold nanoparticle assembly for detection and discrimination of single nucleotide mutation in Duchenne_muscular_dystrophy .
19202550	0	nucleotide	7,17	ERAP1	74,79	nucleotide	ERAP1	CHEBI:36976	51752	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Single nucleotide polymorphisms in antigen processing machinery component ERAP1 significantly associate with clinical outcome in cervical_carcinoma .
22608006	0	nucleotide	56,66	ERCC2	25,30	nucleotide	ERCC2	CHEBI:36976	2068	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nummod|END_ENTITY	Clinical significance of ERCC2 haplotype-tagging single nucleotide polymorphisms in patients with unresectable non-small cell lung_cancer treated with first-line platinum-based chemotherapy .
22848636	0	nucleotide	27,37	ERCC4	55,60	nucleotide	ERCC4	CHEBI:36976	2072	Chemical	Gene	Association|nmod|START_ENTITY polymorphisms|nsubj|Association polymorphisms|nmod|END_ENTITY	Association between single nucleotide polymorphisms in ERCC4 and risk of squamous_cell_carcinoma_of_the_head_and_neck .
12538349	0	nucleotide	58,68	ERK1/2	25,31	nucleotide	ERK1/2	CHEBI:36976	5595;5594	Chemical	Gene	START_ENTITY|nsubj|activation activation|nmod|END_ENTITY	Persistent activation of ERK1/2 by lead_acetate increases nucleotide excision repair synthesis and confers anti-cytotoxicity and anti-mutagenicity .
3840930	0	nucleotide	4,14	ERV3	64,68	nucleotide	ERV3	CHEBI:36976	2086	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The nucleotide sequence of the env gene from the human provirus ERV3 and isolation and characterization of an ERV3-specific cDNA .
18452179	0	nucleotide	24,34	ESR1	56,60	nucleotide	ESR1	CHEBI:36976	2099	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Analysis of five single nucleotide polymorphisms in the ESR1 gene in cryptorchidism .
16439799	0	nucleotide	50,60	Erk1/2	83,89	nucleotide	Erk1/2	CHEBI:36976	5595;5594	Chemical	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	AsialoGM1 and TLR5 cooperate in flagellin-induced nucleotide signaling to activate Erk1/2 .
6091663	0	nucleotide	30,40	Estradiol_receptor	0,18	nucleotide	Estradiol receptor	CHEBI:36976	2099	Chemical	Gene	phosphodiesterase|compound|START_ENTITY phosphodiesterase|compound|END_ENTITY	Estradiol_receptor and cyclic nucleotide phosphodiesterase : functional relationship , possible role of guanine_nucleotide binding proteins .
17680820	0	nucleotide	101,111	FCN2	133,137	nucleotide	FCN2	CHEBI:36976	2220	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Extremes of L-ficolin concentration in children with recurrent infections are associated with single nucleotide polymorphisms in the FCN2 gene .
24053368	0	nucleotide	7,17	FGF23	69,74	nucleotide	FGF23	CHEBI:36976	8074	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|appos|END_ENTITY	Single nucleotide polymorphisms in fibroblast_growth_factor_23 gene , FGF23 , are associated with prostate_cancer risk .
25724586	0	nucleotide	15,25	FHL1	50,54	nucleotide	FHL1	CHEBI:36976	2273	Chemical	Gene	mutation|amod|START_ENTITY mutation|nmod|END_ENTITY	A novel single nucleotide splice site mutation in FHL1 confirms an Emery-Dreifuss plus phenotype with pulmonary_artery_hypoplasia and facial_dysmorphology .
1722474	0	nucleotide	51,61	FKBP	44,48	nucleotide	FKBP	CHEBI:36976	14225(Tax:10090)	Chemical	Gene	protein|dep|START_ENTITY protein|appos|END_ENTITY	cDNA encoding murine FK506-binding protein -LRB- FKBP -RRB- : nucleotide and deduced amino_acid sequence .
16858129	0	nucleotide	19,29	FMO3	51,55	nucleotide	FMO3	CHEBI:36976	2328	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Three novel single nucleotide polymorphisms of the FMO3 gene in a Japanese population .
24559842	0	nucleotide	14,24	FNDC5	46,51	nucleotide	FNDC5	CHEBI:36976	252995	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Common single nucleotide polymorphisms in the FNDC5 gene are associated with glucose metabolism but do not affect serum irisin levels in Japanese men with low fitness levels .
12540636	0	nucleotide	29,39	FOXC2	61,66	nucleotide	FOXC2	CHEBI:36976	14234(Tax:10090)	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Systematic search for single nucleotide polymorphisms in the FOXC2 gene : the absence of evidence for the association of three frequent single nucleotide polymorphisms and four common haplotypes with Japanese type 2 diabetes .
14656218	0	nucleotide	8,18	G18	86,89	nucleotide	G18	CHEBI:36976	63940	Chemical	Gene	START_ENTITY|dobj|activity activity|nmod|END_ENTITY	Guanine nucleotide dissociation inhibitor activity of the triple GoLoco motif protein G18 : alanine-to-aspartate mutation restores function to an inactive second GoLoco motif .
6289944	0	nucleotide	70,80	G6PD	95,99	nucleotide	G6PD	CHEBI:36976	2539	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Hemolytic_anemia in hereditary pyrimidine 5 ' - nucleotidase deficiency : nucleotide inhibition of G6PD and the pentose_phosphate shunt .
18607915	0	nucleotide	22,32	GATA-3	50,56	nucleotide	GATA-3	CHEBI:36976	2625	Chemical	Gene	Association|nmod|START_ENTITY polymorphisms|nsubj|Association polymorphisms|nmod|END_ENTITY	Association of single nucleotide polymorphisms in GATA-3 with allergic_rhinitis .
3025612	0	nucleotide	56,66	GCR1	79,83	nucleotide	GCR1	CHEBI:36976	856030(Tax:4932)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Glycolytic gene expression in Saccharomyces_cerevisiae : nucleotide sequence of GCR1 , null mutants , and evidence for expression .
22707195	0	nucleotide	44,54	GLUT1	26,31	nucleotide	GLUT1	CHEBI:36976	6513	Chemical	Gene	polymorphisms|amod|START_ENTITY polymorphisms|compound|END_ENTITY	Relationship between five GLUT1 gene single nucleotide polymorphisms and diabetic_nephropathy : a systematic review and meta-analysis .
21958378	0	nucleotide	85,95	GSTP1	113,118	nucleotide	GSTP1	CHEBI:36976	2950	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Pharmacogenetics of oxaliplatin as adjuvant treatment in colon_carcinoma : are single nucleotide polymorphisms in GSTP1 , ERCC1 , and ERCC2 good predictive markers ?
11976690	0	nucleotide	57,67	Galpha	79,85	nucleotide	Galpha	CHEBI:36976	8802	Chemical	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits .
16962589	0	nucleotide	4,14	Grp170	43,49	nucleotide	Grp170	CHEBI:36976	10525	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	The nucleotide exchange factor activity of Grp170 may explain the non-lethal phenotype of loss of Sil1 function in man and mouse .
27030672	0	nucleotide	11,21	Grp170	4,10	nucleotide	Grp170	D009711	10525	Chemical	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	The Grp170 nucleotide exchange factor executes a key role during ERAD of cellular misfolded clients .
6823009	0	nucleotide	19,29	H-1	42,45	nucleotide	H-1	CHEBI:36976	3009	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Parvovirus genome : nucleotide sequence of H-1 and mapping of its genes by hybrid-arrested translation .
24510567	0	nucleotide	23,33	H2BFWT	51,57	nucleotide	H2BFWT	CHEBI:36976	158983	Chemical	Gene	Association|nmod|START_ENTITY polymorphisms|nsubj|Association polymorphisms|nmod|END_ENTITY	-LSB- Association of single nucleotide polymorphisms in H2BFWT with male_infertility in southwest China -RSB- .
7096326	0	nucleotide	9,19	H2b	42,45	nucleotide	H2b	CHEBI:36976	519934(Tax:9913)	Chemical	Gene	sequence|compound|START_ENTITY sequence|nmod|END_ENTITY	Complete nucleotide sequence of a chicken H2b histone gene .
26464710	0	nucleotide	7,17	HER2	35,39	nucleotide	HER2	D009711	2064	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Single nucleotide polymorphisms of HER2 related to osteosarcoma susceptibility .
25700369	0	nucleotide	7,17	HIF-1a	35,41	nucleotide	HIF-1a	CHEBI:36976	3091	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Single nucleotide polymorphisms in HIF-1a gene and residual ridge resorption -LRB- RRR -RRB- of mandible in Korean population .
14975234	0	nucleotide	57,67	HINT	22,26	nucleotide	HINT	CHEBI:36976	3094	Chemical	Gene	function|nmod|START_ENTITY END_ENTITY|nmod|function	Mast cells provide a `` HINT '' to the function of an exotic nucleotide .
19123127	0	nucleotide	61,71	HINTW	89,94	nucleotide	HINTW	CHEBI:36976	395423(Tax:9031)	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Genetic evidence against a role for W-linked histidine triad nucleotide binding protein -LRB- HINTW -RRB- in avian sex determination .
23540226	0	nucleotide	55,65	HIPK2	83,88	nucleotide	HIPK2	CHEBI:36976	28996	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	No associations between rs2030712 and rs7456421 single nucleotide polymorphisms of HIPK2 gene and prevalence of chronic_kidney_disease .
8106270	0	nucleotide	9,19	HLA-B	32,37	nucleotide	HLA-B	CHEBI:36976	3106	Chemical	Gene	sequence|compound|START_ENTITY sequence|nmod|END_ENTITY	Complete nucleotide sequence of HLA-B * 0703 , a B7 variant -LRB- BPOT -RRB- .
2071937	0	nucleotide	9,19	HLA-C	32,37	nucleotide	HLA-C	CHEBI:36976	3107	Chemical	Gene	sequence|compound|START_ENTITY sequence|nmod|END_ENTITY	Specific nucleotide sequence of HLA-C is strongly associated with psoriasis_vulgaris .
11019926	0	nucleotide	14,24	HLA-DRB1	53,61	nucleotide	HLA-DRB1	CHEBI:36976	3123	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	New HLA-DRB1 * nucleotide sequence of Italian origin : HLA-DRB1 * 13022 .
9306097	0	nucleotide	9,19	HLA-DRB1	36,44	nucleotide	HLA-DRB1	CHEBI:36976	3123	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Complete nucleotide sequence of the HLA-DRB1 * 1302 allele .
16033759	0	nucleotide	14,24	HMGA1	72,77	nucleotide	HMGA1	CHEBI:36976	3159	Chemical	Gene	excision|amod|START_ENTITY Inhibition|nmod|excision repair|nsubj|Inhibition repair|nmod|END_ENTITY	Inhibition of nucleotide excision repair by high mobility group protein HMGA1 .
1686012	0	nucleotide	47,57	HOX3A	90,95	nucleotide	HOX3A	CHEBI:36976	3224	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Molecular cloning , chromosomal assignment , and nucleotide sequence of the feline homeobox HOX3A .
11500064	0	nucleotide	95,105	HPFH	122,126	nucleotide	HPFH	CHEBI:36976	7954	Chemical	Gene	START_ENTITY|acl|associated associated|nmod|END_ENTITY	Targeted correction of the point mutations of beta-thalassemia and targeted mutagenesis of the nucleotide associated with HPFH by RNA/DNA oligonucleotides : potential for beta-thalassemia gene therapy .
19406828	0	nucleotide	45,55	HPSE	28,32	nucleotide	HPSE	CHEBI:36976	10855	Chemical	Gene	polymorphisms|amod|START_ENTITY polymorphisms|amod|END_ENTITY	Inverse correlation between HPSE gene single nucleotide polymorphisms and heparanase expression : possibility of multiple levels of heparanase regulation .
26115144	0	nucleotide	68,78	HSD11B2	96,103	nucleotide	HSD11B2	D009711	3291	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Investigating interactions between early life stress and two single nucleotide polymorphisms in HSD11B2 on the risk of schizophrenia .
27026916	0	nucleotide	7,17	HSP90AA1	35,43	nucleotide	HSP90AA1	D009711	3320	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Single nucleotide polymorphisms of HSP90AA1 gene influence response of SLE patients to glucocorticoids treatment .
20533271	0	nucleotide	29,39	HTRA1	57,62	nucleotide	HTRA1	CHEBI:36976	5654	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	-LSB- Association study on single nucleotide polymorphisms in HTRA1 gene and rheumatoid_arthritis -RSB- .
9182823	0	nucleotide	17,27	Hermansky-Pudlak_syndrome	50,75	nucleotide	Hermansky-Pudlak syndrome	CHEBI:36976	3257	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Organization and nucleotide sequence of the human Hermansky-Pudlak_syndrome -LRB- HPS -RRB- gene .
7916214	0	nucleotide	4,14	Hox-D3	38,44	nucleotide	Hox-D3	CHEBI:36976	15434(Tax:10090)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|gene gene|compound|END_ENTITY	The nucleotide sequence of the murine Hox-D3 -LRB- Hox-4 .1 -RRB- gene reveals extensive identity with the human protein .
12417338	0	nucleotide	69,79	Hsc70	63,68	nucleotide	Hsc70	CHEBI:36976	3312	Chemical	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	HspBP1 , a homologue of the yeast Fes1 and Sls1 proteins , is an Hsc70 nucleotide exchange factor .
14984055	0	nucleotide	9,19	Hsc70	39,44	nucleotide	Hsc70	CHEBI:36976	3312	Chemical	Gene	factor|amod|START_ENTITY factor|nmod|END_ENTITY	BAG-1 -- a nucleotide exchange factor of Hsc70 with multiple cellular functions .
11867765	0	nucleotide	119,129	Hsp104	70,76	nucleotide	Hsp104	CHEBI:36976	850633(Tax:4932)	Chemical	Gene	Analysis|nmod|START_ENTITY Analysis|nmod|END_ENTITY	Analysis of the AAA sensor-2 motif in the C-terminal ATPase domain of Hsp104 with a site-specific fluorescent probe of nucleotide binding .
11054293	0	nucleotide	59,69	Hsp90	22,27	nucleotide	Hsp90	CHEBI:36976	3320	Chemical	Gene	trapping|dobj|START_ENTITY important|advcl|trapping important|nsubj|regions regions|nmod|END_ENTITY	C-terminal regions of Hsp90 are important for trapping the nucleotide during the ATPase cycle .
12755697	0	nucleotide	58,68	Hsp90	49,54	nucleotide	Hsp90	CHEBI:36976	3320	Chemical	Gene	cleavage|amod|START_ENTITY END_ENTITY|nmod|cleavage	Comparative analysis of the ATP-binding sites of Hsp90 by nucleotide affinity cleavage : a distinct nucleotide specificity of the C-terminal ATP-binding site .
12755697	0	nucleotide	99,109	Hsp90	49,54	nucleotide	Hsp90	CHEBI:36976	3320	Chemical	Gene	specificity|compound|START_ENTITY analysis|dep|specificity analysis|nmod|sites sites|nmod|END_ENTITY	Comparative analysis of the ATP-binding sites of Hsp90 by nucleotide affinity cleavage : a distinct nucleotide specificity of the C-terminal ATP-binding site .
17101799	6	nucleotide	1179,1189	Hsp90	1112,1117	nucleotide	Hsp90	CHEBI:36976	855836(Tax:4932)	Chemical	Gene	presence|nmod|START_ENTITY interaction|nmod|presence displayed|dobj|interaction displayed|nsubj|forms forms|nmod|END_ENTITY	Some mutant forms of Hsp90 also displayed reduced Sti1 interaction in the presence of a nucleotide .
19554567	0	nucleotide	113,123	Hsp90	33,38	nucleotide	Hsp90	CHEBI:36976	855836(Tax:4932)	Chemical	Gene	absence|nmod|START_ENTITY Hsp90|nmod|absence has|nmod|Hsp90 has|nsubj|Grp94 Grp94|appos|END_ENTITY	Grp94 , the endoplasmic reticulum Hsp90 , has a similar solution conformation to cytosolic Hsp90 in the absence of nucleotide .
19554567	0	nucleotide	113,123	Hsp90	89,94	nucleotide	Hsp90	CHEBI:36976	855836(Tax:4932)	Chemical	Gene	absence|nmod|START_ENTITY END_ENTITY|nmod|absence	Grp94 , the endoplasmic reticulum Hsp90 , has a similar solution conformation to cytosolic Hsp90 in the absence of nucleotide .
25132583	0	nucleotide	123,133	IL-10	184,189	nucleotide	IL-10	CHEBI:36976	3586	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Incidence and dynamics of active cytomegalovirus_infection in allogeneic stem cell transplant patients according to single nucleotide polymorphisms in donor and recipient CCR5 , MCP-1 , IL-10 , and TLR9 genes .
2535858	0	nucleotide	9,19	IL-4	63,67	nucleotide	IL-4	CHEBI:36976	3565	Chemical	Gene	sequence|compound|START_ENTITY sequence|nmod|END_ENTITY	Complete nucleotide sequence of the chromosomal gene for human IL-4 and its expression .
21196282	0	nucleotide	7,17	IL-4Ra	35,41	nucleotide	IL-4Ra	CHEBI:36976	3566	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|genes genes|compound|END_ENTITY	Single nucleotide polymorphisms in IL-4Ra , IL-13 and STAT6 genes occurs in brain_glioma .
26813132	0	nucleotide	23,33	IL-6	51,55	nucleotide	IL-6	D009711	3569	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	-LSB- Association of single nucleotide polymorphisms of IL-6 gene with longevity in Uyghurs in Xinjiang -RSB- .
24628819	0	nucleotide	12,22	IL10	0,4	nucleotide	IL10	CHEBI:36976	3586	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nummod|END_ENTITY	IL10 single nucleotide polymorphisms are related to upregulation of constitutive IL-10 production and susceptibility to Helicobacter_pylori_infection .
26831416	0	nucleotide	49,59	IL13	98,102	nucleotide	IL13	D009711	3596	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|appos|END_ENTITY	A preliminary study on the association of single nucleotide polymorphisms of interleukin_4 -LRB- IL4 -RRB- , IL13 , IL4 receptor alpha -LRB- IL4Ra -RRB- _ Toll-like_receptor_4 -LRB- TLR4 -RRB- genes with asthma in Indian adults .
15806006	0	nucleotide	7,17	IL18	39,43	nucleotide	IL18	CHEBI:36976	3606	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Single nucleotide polymorphisms of the IL18 gene are associated with atopic_eczema .
22768033	0	nucleotide	7,17	IL1B	35,39	nucleotide	IL1B	CHEBI:36976	3553	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Single nucleotide polymorphisms in IL1B and the risk of acute_coronary_syndrome : a Danish case-cohort study .
26891860	0	nucleotide	23,33	IL1B	11,15	nucleotide	IL1B	D009711	3553	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nummod|END_ENTITY	Effects of IL1B single nucleotide polymorphisms on depressive_and_anxiety_symptoms are determined by severity and type of life stress .
22087138	0	nucleotide	7,17	IL28B	39,44	nucleotide	IL28B	CHEBI:36976	282617	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Single nucleotide polymorphisms of the IL28B and sustained virologic response of patients with chronic hepatitis_C to PEG-interferon/ribavirin therapy : A meta-analysis : Meta-analysis of IL28B .
22200702	0	nucleotide	29,39	IL28B	57,62	nucleotide	IL28B	CHEBI:36976	282617	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	-LSB- Relationship between single nucleotide polymorphisms in IL28B gene and response to interferon treatment in chronic hepatitis_B patients -RSB- .
26831416	0	nucleotide	49,59	IL4	92,95	nucleotide	IL4	D009711	3565	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|appos|END_ENTITY	A preliminary study on the association of single nucleotide polymorphisms of interleukin_4 -LRB- IL4 -RRB- , IL13 , IL4 receptor alpha -LRB- IL4Ra -RRB- _ Toll-like_receptor_4 -LRB- TLR4 -RRB- genes with asthma in Indian adults .
26387812	0	nucleotide	22,32	IL8	50,53	nucleotide	IL8	D009711	3576	Chemical	Gene	Association|nmod|START_ENTITY polymorphisms|nsubj|Association polymorphisms|nmod|END_ENTITY	Association of single nucleotide polymorphisms in IL8 and IL13 with sunitinib-induced toxicity in patients with metastatic_renal_cell_carcinoma .
26387812	0	nucleotide	22,32	IL8	50,53	nucleotide	IL8	D009711	3576	Chemical	Gene	Association|nmod|START_ENTITY polymorphisms|nsubj|Association polymorphisms|nmod|END_ENTITY	Association of single nucleotide polymorphisms in IL8 and IL13 with sunitinib-induced toxicity in patients with metastatic_renal_cell_carcinoma .
21221916	0	nucleotide	23,33	IMB-1	64,69	nucleotide	IMB-1	CHEBI:36976	3837	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Isolation and complete nucleotide sequence of the measles_virus IMB-1 strain in China .
25728941	0	nucleotide	56,66	ITGB4	42,47	nucleotide	ITGB4	CHEBI:36976	3691	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Splicing abnormality of integrin b4 gene -LRB- ITGB4 -RRB- due to nucleotide substitutions far from splice site underlies pyloric_atresia-junctional_epidermolysis_bullosa_syndrome .
12444902	0	nucleotide	43,53	Insulin	0,7	nucleotide	Insulin	CHEBI:36976	3630	Chemical	Gene	pathway|compound|START_ENTITY influences|dobj|pathway influences|nsubj|END_ENTITY	Insulin influences the nitric_oxide cyclic nucleotide pathway in cultured human smooth muscle cells from corpus cavernosum by rapidly activating a constitutive nitric_oxide synthase .
7589879	0	nucleotide	25,35	Insulin	0,7	nucleotide	Insulin	CHEBI:36976	3630	Chemical	Gene	increases|dobj|START_ENTITY increases|nsubj|END_ENTITY	Insulin increases cyclic nucleotide content in human vascular smooth muscle cells : a mechanism potentially involved in insulin-induced modulation of vascular tone .
24063019	0	nucleotide	46,56	Interleukin-1	20,33	nucleotide	Interleukin-1	CHEBI:36976	3552	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|compound|END_ENTITY	Association between Interleukin-1 gene single nucleotide polymorphisms and ischemic_stroke classified by TOAST criteria in the Han population of northern China .
22113416	0	nucleotide	7,17	JAZF1	35,40	nucleotide	JAZF1	CHEBI:36976	221895	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Single nucleotide polymorphisms in JAZF1 and BCL11A gene are nominally associated with type_2_diabetes in African-American families from the GENNID study .
22357531	0	nucleotide	33,43	JWA	61,64	nucleotide	JWA	CHEBI:36976	10550	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	-LSB- The relationship between single nucleotide polymorphisms of JWA gene and susceptibility to hypertension in workers exposed to heat stress -RSB- .
12957169	0	nucleotide	44,54	K-ras	76,81	nucleotide	K-ras	CHEBI:36976	3845	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Simultaneous genotyping of multiplex single nucleotide polymorphisms of the K-ras gene with a home-made kit .
16946706	0	nucleotide	38,48	KIF1A	67,72	nucleotide	KIF1A	CHEBI:36976	547	Chemical	Gene	pocket|amod|START_ENTITY pocket|nmod|END_ENTITY	High-resolution cryo-EM maps show the nucleotide binding pocket of KIF1A in open and closed conformations .
18249219	0	nucleotide	22,32	LEPR	87,91	nucleotide	LEPR	CHEBI:36976	3953	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Interaction of single nucleotide polymorphisms in ADRB2 , ADRB3 , TNF , IL6 , IGF1R , LIPC , LEPR , and GHRL with physical activity on the risk of type_2_diabetes_mellitus and changes in characteristics of the metabolic_syndrome : The Finnish Diabetes Prevention Study .
21620500	0	nucleotide	27,37	LIG3	75,79	nucleotide	LIG3	CHEBI:36976	3980	Chemical	Gene	Association|nmod|START_ENTITY polymorphisms|nsubj|Association polymorphisms|nmod|END_ENTITY	Association between single nucleotide polymorphisms in the DNA repair gene LIG3 and acute adverse skin reactions following radiotherapy .
24069331	0	nucleotide	7,17	LIPA	39,43	nucleotide	LIPA	CHEBI:36976	3988	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Single nucleotide polymorphisms within LIPA -LRB- Lysosomal Acid Lipase A -RRB- gene are associated with susceptibility to premature coronary_artery_disease .
26379929	0	nucleotide	17,27	LMNA	0,4	nucleotide	LMNA	D009711	4000	Chemical	Gene	polymorphisms|amod|START_ENTITY single|dobj|polymorphisms single|nsubj|gene gene|compound|END_ENTITY	LMNA gene single nucleotide polymorphisms in dilated_cardiomyopathy of Han children .
19759005	0	nucleotide	49,59	Lhs1p	22,27	nucleotide	Lhs1p	CHEBI:36976	853789(Tax:4932)	Chemical	Gene	activity|amod|START_ENTITY essential|nmod|activity essential|nsubj|binding binding|nmod|END_ENTITY	Nucleotide binding by Lhs1p is essential for its nucleotide exchange activity and for function in vivo .
16650944	0	nucleotide	7,17	Lmbr1	47,52	nucleotide	Lmbr1	CHEBI:36976	373986(Tax:9031)	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Single nucleotide polymorphisms in the chicken Lmbr1 gene are associated with chicken polydactyly .
9426595	0	nucleotide	89,99	Lysine-ketoglutarate_reductase	0,30	nucleotide	Lysine-ketoglutarate reductase	CHEBI:36976	829452(Tax:3702)	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|dep|sequence	Lysine-ketoglutarate_reductase and saccharopine_dehydrogenase from Arabidopsis_thaliana : nucleotide sequence and characterization .
24972815	0	nucleotide	28,38	MAFB	56,60	nucleotide	MAFB	CHEBI:36976	9935	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Association study of single nucleotide polymorphisms of MAFB with non-syndromic cleft_lip with or without cleft_palate in a population in Heilongjiang Province , northern China .
24423752	0	nucleotide	80,90	MARC1	108,113	nucleotide	MARC1	CHEBI:36976	64757	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Functional characterization of protein variants encoded by nonsynonymous single nucleotide polymorphisms in MARC1 and MARC2 in healthy Caucasians .
21308753	0	nucleotide	91,101	MATN1	119,124	nucleotide	MATN1	CHEBI:36976	4146	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Lack of association between adolescent idiopathic scoliosis and previously reported single nucleotide polymorphisms in MATN1 , MTNR1B , TPH1 , and IGF1 in a Japanese population .
15714523	0	nucleotide	7,17	MATP	39,43	nucleotide	MATP	CHEBI:36976	51151	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Single nucleotide polymorphisms in the MATP gene are associated with normal human pigmentation variation .
18198296	0	nucleotide	7,17	MCHR1	39,44	nucleotide	MCHR1	CHEBI:36976	2847	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Single nucleotide polymorphisms of the MCHR1 gene do not affect metabolism in humans .
23185481	0	nucleotide	7,17	MCP-1	35,40	nucleotide	MCP-1	CHEBI:36976	6347	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Single nucleotide polymorphisms in MCP-1 and its receptor are associated with the risk of age related macular_degeneration .
14685825	0	nucleotide	14,24	MDR1	46,50	nucleotide	MDR1	CHEBI:36976	5243	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Common single nucleotide polymorphisms of the MDR1 gene have no influence on its mRNA expression level of normal kidney cortex and renal_cell_carcinoma in Japanese nephrectomized patients .
9096229	0	nucleotide	36,46	MFA2	79,83	nucleotide	MFA2	CHEBI:36976	855577(Tax:4932)	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Excision repair at the level of the nucleotide in the Saccharomyces_cerevisiae MFA2 gene : mapping of where enhanced repair in the transcribed strand begins or ends and identification of only a partial rad16 requisite for repairing upstream control sequences .
21512861	0	nucleotide	7,17	MMP-14	50,56	nucleotide	MMP-14	CHEBI:36976	4323	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Single nucleotide polymorphisms and haplotypes of MMP-14 are associated with the risk and pathological development of oral_cancer .
19889076	0	nucleotide	12,22	MMP-9	40,45	nucleotide	MMP-9	CHEBI:36976	4318	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Host single nucleotide polymorphisms of MMP-9 -1562 / TIMP-1 372 have gender differences in the risk of gastric_intestinal_metaplasia after Helicobacter_pylori_infection .
22113040	0	nucleotide	37,47	MMP7	65,69	nucleotide	MMP7	CHEBI:36976	4316	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	-LSB- Study on association between single nucleotide polymorphisms of MMP7 , MMP8 , MMP9 genes and development of gastric_cancer and lymph_node_metastasis -RSB- .
25670000	0	nucleotide	44,54	MMP9	76,80	nucleotide	MMP9	CHEBI:36976	4318	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	MS susceptibility is not affected by single nucleotide polymorphisms in the MMP9 gene .
11469806	0	nucleotide	45,55	MRP1	103,107	nucleotide	MRP1	CHEBI:36976	4363	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Mutations of the Walker B motif in the first nucleotide binding domain of multidrug resistance protein MRP1 prevent conformational maturation .
2448588	0	nucleotide	58,68	MRS3	100,104	nucleotide	MRS3	CHEBI:36976	853308(Tax:4932)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|gene gene|compound|END_ENTITY	Nuclear suppression of a mitochondrial RNA splice defect : nucleotide sequence and disruption of the MRS3 gene .
25232430	0	nucleotide	7,17	MSH2	61,65	nucleotide	MSH2	CHEBI:36976	4436	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Single nucleotide polymorphisms of DNA mismatch repair genes MSH2 and MLH1 confer susceptibility to esophageal_cancer .
24338217	0	nucleotide	22,32	MTHFR	50,55	nucleotide	MTHFR	CHEBI:36976	4524	Chemical	Gene	Association|nmod|START_ENTITY polymorphisms|nsubj|Association polymorphisms|nmod|END_ENTITY	Association of single nucleotide polymorphisms in MTHFR and ABCG2 with the different efficacy of first-line chemotherapy in metastatic colorectal_cancer .
26567828	0	nucleotide	61,71	MYH7	119,123	nucleotide	MYH7	D009711	4625	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Electrochemical primer extension for the detection of single nucleotide polymorphisms in the cardiomyopathy associated MYH7 gene .
14592789	0	nucleotide	78,88	Mac-1	97,102	nucleotide	Mac-1	CHEBI:36976	3684	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Neutrophil chemotaxis : potential role of chemokine receptors in extracellular nucleotide induced Mac-1 expression .
1699607	0	nucleotide	32,42	Manganese_superoxide_dismutase	0,30	nucleotide	Manganese superoxide dismutase	CHEBI:36976	6648	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|dep|sequence	Manganese_superoxide_dismutase : nucleotide and deduced amino_acid sequence of a cDNA encoding a new human transcript .
26609515	0	nucleotide	27,37	MiR219-1	55,63	nucleotide	MiR219-1	D009711	407002	Chemical	Gene	Association|nmod|START_ENTITY polymorphisms|nsubj|Association polymorphisms|nmod|END_ENTITY	Association between single nucleotide polymorphisms in MiR219-1 and MiR137 and susceptibility to schizophrenia in a Chinese population .
23458407	0	nucleotide	38,48	Msh3	33,37	nucleotide	Msh3	CHEBI:36976	850454(Tax:4932)	Chemical	Gene	START_ENTITY|nsubj|requirements requirements|nmod|END_ENTITY	Distinct requirements within the Msh3 nucleotide binding pocket for mismatch and double-strand break repair .
20039646	0	nucleotide	35,45	Myo1c	68,73	nucleotide	Myo1c	CHEBI:36976	4641	Chemical	Gene	properties|amod|START_ENTITY properties|nmod|END_ENTITY	Modification of loop 1 affects the nucleotide binding properties of Myo1c , the adaptation motor in the inner ear .
20640478	0	nucleotide	83,93	Myo1c	0,5	nucleotide	Myo1c	CHEBI:36976	4641	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubj|mutations mutations|amod|END_ENTITY	Myo1c mutations associated with hearing_loss cause defects in the interaction with nucleotide and actin .
15184651	0	nucleotide	57,67	Myosin	0,6	nucleotide	Myosin	CHEBI:36976	79784	Chemical	Gene	reveal|dobj|START_ENTITY reveal|nsubj|structures structures|amod|END_ENTITY	Myosin subfragment 1 structures reveal a partially bound nucleotide and a complex salt bridge that helps couple nucleotide and actin binding .
20226094	0	nucleotide	30,40	Myosin	0,6	nucleotide	Myosin	CHEBI:36976	79784	Chemical	Gene	polymorphisms|compound|START_ENTITY individualized|dep|polymorphisms individualized|compound|END_ENTITY	Myosin individualized : single nucleotide polymorphisms in energy transduction .
16011304	0	nucleotide	35,45	N-acetyl-D-glucosamine_2-epimerase	68,102	nucleotide	N-acetyl-D-glucosamine 2-epimerase	CHEBI:36976	5973	Chemical	Gene	properties|amod|START_ENTITY properties|nmod|END_ENTITY	Amino_acid residues conferring the nucleotide binding properties of N-acetyl-D-glucosamine_2-epimerase -LRB- renin_binding_protein -RRB- .
11926999	0	nucleotide	38,48	N-acetyl-d-glucosamine_2-epimerase	64,98	nucleotide	N-acetyl-d-glucosamine 2-epimerase	CHEBI:36976	5973	Chemical	Gene	START_ENTITY|xcomp|binding binding|nmod|END_ENTITY	Identification of a domain conferring nucleotide binding to the N-acetyl-d-glucosamine_2-epimerase -LRB- Renin_binding_protein -RRB- .
12088197	0	nucleotide	10,20	N-acetyltransferase-1	38,59	nucleotide	N-acetyltransferase-1	CHEBI:36976	9	Chemical	Gene	substitutions|amod|START_ENTITY substitutions|nmod|END_ENTITY	Effect of nucleotide substitutions in N-acetyltransferase-1 on N-acetylation -LRB- deactivation -RRB- and O-acetylation -LRB- activation -RRB- of arylamine carcinogens : implications for cancer predisposition .
16570281	0	nucleotide	18,28	N-acetyltransferase_2	52,73	nucleotide	N-acetyltransferase 2	CHEBI:36976	10	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Effects of single nucleotide polymorphisms in human N-acetyltransferase_2 on metabolic activation -LRB- O-acetylation -RRB- of heterocyclic_amine_carcinogens .
25966125	0	nucleotide	66,76	NOD2	98,102	nucleotide	NOD2	D009711	444867(Tax:9913)	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Health and production traits in bovine are associated with single nucleotide polymorphisms in the NOD2 gene .
22368302	0	nucleotide	7,17	NOS2	39,43	nucleotide	NOS2	CHEBI:36976	4843	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|genes genes|compound|END_ENTITY	Single nucleotide polymorphisms in the NOS2 and NOS3 genes are associated with exhaled nitric_oxide .
22862164	0	nucleotide	7,17	NOS2A	35,40	nucleotide	NOS2A	CHEBI:36976	4843	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|genes genes|compound|END_ENTITY	Single nucleotide polymorphisms in NOS2A and NOS3 genes are not associated with treatment response of non-small_cell_lung_cancer patients following the definitive radiochemotherapy .
20543198	0	nucleotide	41,51	NPPA	29,33	nucleotide	NPPA	CHEBI:36976	4878	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|compound|END_ENTITY	Evaluation of non-synonymous NPPA single nucleotide polymorphisms in atrial_fibrillation .
23073785	0	nucleotide	7,17	NR3C1	35,40	nucleotide	NR3C1	CHEBI:36976	2908	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Single nucleotide polymorphisms of NR3C1 gene and recurrent depressive_disorder in population of Poland .
17034726	0	nucleotide	29,39	NRAMP1	57,63	nucleotide	NRAMP1	CHEBI:36976	6556	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	-LSB- Relationship between single nucleotide polymorphisms of NRAMP1 gene and susceptibility to pulmonary_tuberculosis in workers exposed to silica dusts -RSB- .
23526990	0	nucleotide	77,87	NTPase	13,19	nucleotide	NTPase	CHEBI:36976	84284	Chemical	Gene	START_ENTITY|nsubj|activity activity|amod|END_ENTITY	Steady-state NTPase activity of Dengue_virus_NS3 : number of catalytic sites , nucleotide specificity and activation by ssRNA .
23831349	0	nucleotide	32,42	NTRK2	64,69	nucleotide	NTRK2	CHEBI:36976	4915	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	The relationship between single nucleotide polymorphisms of the NTRK2 gene and sporadic Alzheimer 's _ disease in the Chinese Han population .
21275845	0	nucleotide	48,58	Ncf1	66,70	nucleotide	Ncf1	CHEBI:36976	114553(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|gene gene|amod|END_ENTITY	Positioning of a polymorphic quantitative trait nucleotide in the Ncf1 gene controlling oxidative burst response and arthritis severity in rats .
17439653	0	nucleotide	9,19	Nppc	32,36	nucleotide	Nppc	CHEBI:36976	18159(Tax:10090)	Chemical	Gene	mutation|compound|START_ENTITY mutation|nmod|END_ENTITY	A single nucleotide mutation in Nppc is associated with a long bone abnormality in lbab mice .
19472299	0	nucleotide	26,36	OCA2	58,62	nucleotide	OCA2	CHEBI:36976	4948	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|genes genes|compound|END_ENTITY	Genotyping of five single nucleotide polymorphisms in the OCA2 and HERC2 genes associated with blue-brown_eye_color in the Japanese population .
15459889	0	nucleotide	77,87	OCTN1	64,69	nucleotide	OCTN1	CHEBI:36976	6583	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nummod|END_ENTITY	Functional characterization of human organic cation transporter OCTN1 single nucleotide polymorphisms in the Japanese population .
16437728	0	nucleotide	7,17	OCTN1	35,40	nucleotide	OCTN1	D009711	6583	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Single nucleotide polymorphisms of OCTN1 , OCTN2 , and DLG5 genes in Greek patients with Crohn 's _ disease .
2823258	0	nucleotide	84,94	OXA-1	111,116	nucleotide	OXA-1	CHEBI:36976	5018	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|gene gene|compound|END_ENTITY	Precise insertion of antibiotic resistance determinants into Tn21-like transposons : nucleotide sequence of the OXA-1 beta-lactamase gene .
16370938	0	nucleotide	7,17	P-glycoprotein	41,55	nucleotide	P-glycoprotein	CHEBI:36976	5243	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Single nucleotide polymorphisms in human P-glycoprotein : its impact on drug delivery and disposition .
23167335	0	nucleotide	61,71	P21	41,44	nucleotide	P21	CHEBI:36976	644914	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nummod|END_ENTITY	MDM2 T309G has a synergistic effect with P21 ser31arg single nucleotide polymorphisms on the risk of acute_myeloid_leukemia .
12495655	0	nucleotide	54,64	P2X1	34,38	nucleotide	P2X1	CHEBI:36976	5023	Chemical	Gene	START_ENTITY|nsubj|identification identification|nmod|END_ENTITY	Pharmacological identification of P2X1 , P2X4 and P2X7 nucleotide receptors in the smooth muscles of human umbilical cord and chorionic blood vessels .
14672995	0	nucleotide	16,26	P2X2	27,31	nucleotide	P2X2	CHEBI:36976	231602(Tax:10090)	Chemical	Gene	subunit|amod|START_ENTITY subunit|compound|END_ENTITY	Pivotal role of nucleotide P2X2 receptor subunit of the ATP-gated ion channel mediating ventilatory responses to hypoxia .
17706883	0	nucleotide	104,114	P2X2	99,103	nucleotide	P2X2	CHEBI:36976	231602(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Abnormalities in neuromuscular junction structure and skeletal muscle function in mice lacking the P2X2 nucleotide receptor .
12819199	0	nucleotide	72,82	P2X4	67,71	nucleotide	P2X4	CHEBI:36976	29659(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Histidine 140 plays a key role in the inhibitory modulation of the P2X4 nucleotide receptor by copper but not zinc .
12660148	0	nucleotide	68,78	P2X7	63,67	nucleotide	P2X7	CHEBI:36976	5027	Chemical	Gene	receptor|amod|START_ENTITY receptor|nummod|END_ENTITY	Essential role for Ca2 + in regulation of IL-1beta secretion by P2X7 nucleotide receptor in monocytes , macrophages , and HEK-293 cells .
15120006	0	nucleotide	24,34	P2X7	44,48	nucleotide	P2X7	CHEBI:36976	5027	Chemical	Gene	receptor|amod|START_ENTITY detect|dobj|receptor novel|xcomp|detect END_ENTITY|amod|novel	A novel assay to detect nucleotide receptor P2X7 genetic polymorphisms influencing numerous innate immune functions .
17135244	0	nucleotide	5,15	P2X7	0,4	nucleotide	P2X7	CHEBI:36976	18439(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	P2X7 nucleotide receptors mediate blebbing in osteoblasts through a pathway involving lysophosphatidic_acid .
17544414	0	nucleotide	57,67	P2X7	52,56	nucleotide	P2X7	CHEBI:36976	18439(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|correlates correlates|nmod|hypersensitivity hypersensitivity|nmod|END_ENTITY	Prion infection correlates with hypersensitivity of P2X7 nucleotide receptor in a mouse microglial cell line .
17558311	0	nucleotide	7,17	P2X7	39,43	nucleotide	P2X7	CHEBI:36976	5027	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Single nucleotide polymorphisms in the P2X7 gene are associated to fracture risk and to effect of estrogen treatment .
17928361	0	nucleotide	91,101	P2X7	35,39	nucleotide	P2X7	CHEBI:36976	5027	Chemical	Gene	site|compound|START_ENTITY ligand|nmod|site covalent|acl|ligand presenting|dobj|covalent gates|advcl|presenting gates|dobj|channel channel|compound|END_ENTITY	ADP-ribosylation at R125 gates the P2X7 ion channel by presenting a covalent ligand to its nucleotide binding site .
21651910	0	nucleotide	34,44	P2X7	20,24	nucleotide	P2X7	CHEBI:36976	18439(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|END_ENTITY	Opposite effects of P2X7 and P2Y2 nucleotide receptors on a-secretase-dependent APP processing in Neuro-2a cells .
24222214	0	nucleotide	13,23	P2X7	8,12	nucleotide	P2X7	D009711	18439(Tax:10090)	Chemical	Gene	function|amod|START_ENTITY function|compound|END_ENTITY	Loss of P2X7 nucleotide receptor function leads to abnormal fat distribution in mice .
9715267	0	nucleotide	19,29	P2X7	14,18	nucleotide	P2X7	CHEBI:36976	5027	Chemical	Gene	START_ENTITY|nsubj|Modulation Modulation|nmod|END_ENTITY	Modulation of P2X7 nucleotide receptor expression by pro- and anti-inflammatory stimuli in THP-1 monocytes .
14764443	0	nucleotide	18,28	P2Y	14,17	nucleotide	P2Y	CHEBI:36976	25265(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of P2Y nucleotide receptors and ectonucleotidases in quiescent and activated rat hepatic stellate cells .
15322238	0	nucleotide	95,105	P2Y	91,94	nucleotide	P2Y	CHEBI:36976	25265(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|nummod|END_ENTITY	Activation and inhibition of neuronal G protein-gated inwardly rectifying K -LRB- + -RRB- channels by P2Y nucleotide receptors .
14718252	0	nucleotide	39,49	P2Y1	24,28	nucleotide	P2Y1	CHEBI:36976	5028	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|END_ENTITY	Differential effects of P2Y1 and P2Y12 nucleotide receptors on ERK1/ERK2 and phosphatidylinositol 3-kinase signalling and cell proliferation in serum-deprived and nonstarved glioma C6 cells .
16957090	0	nucleotide	19,29	P2Y1	14,18	nucleotide	P2Y1	CHEBI:36976	25265(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|nummod|END_ENTITY	Activation of P2Y1 nucleotide receptors induces inhibition of the M-type K + current in rat hippocampal pyramidal neurons .
17355284	0	nucleotide	61,71	P2Y1	46,50	nucleotide	P2Y1	CHEBI:36976	5028	Chemical	Gene	START_ENTITY|nsubj|characterization characterization|nmod|END_ENTITY	Expression and functional characterization of P2Y1 and P2Y12 nucleotide receptors in long-term serum-deprived glioma C6 cells .
18174464	0	nucleotide	57,67	P2Y1	52,56	nucleotide	P2Y1	CHEBI:36976	5028	Chemical	Gene	receptor-mediated|amod|START_ENTITY pathways|amod|receptor-mediated pathways|nummod|END_ENTITY	ADP stimulates human endothelial cell migration via P2Y1 nucleotide receptor-mediated mitogen-activated protein kinase pathways .
19672446	0	nucleotide	28,38	P2Y1	14,18	nucleotide	P2Y1	CHEBI:36976	5028	Chemical	Gene	START_ENTITY|nsubj|Activation Activation|nmod|END_ENTITY	Activation of P2Y1 and P2Y2 nucleotide receptors by adenosine_5 ' - triphosphate analogues augmented nerve-mediated relaxation of human_corpus_cavernosum .
9142866	0	nucleotide	16,26	P2Y1	11,15	nucleotide	P2Y1	CHEBI:36976	25265(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Changes Changes|nmod|END_ENTITY	Changes in P2Y1 nucleotide receptor activity during the development of rat salivary glands .
11723245	0	nucleotide	151,161	P2Y11	196,201	nucleotide	P2Y11	CHEBI:36976	5032	Chemical	Gene	selectivities|amod|START_ENTITY selectivities|nmod|receptors receptors|compound|END_ENTITY	An arginine/glutamine difference at the juxtaposition of transmembrane domain 6 and the third extracellular loop contributes to the markedly different nucleotide selectivities of human and canine P2Y11 receptors .
16953187	0	nucleotide	57,67	P2Y11	51,56	nucleotide	P2Y11	CHEBI:36976	5032	Chemical	Gene	receptors|amod|START_ENTITY receptors|nummod|END_ENTITY	Opposite diastereoselective activation of P2Y1 and P2Y11 nucleotide receptors by adenosine_5 ' - O - -LRB- alpha-boranotriphosphate -RRB- analogues .
17338680	0	nucleotide	69,79	P2Y11	63,68	nucleotide	P2Y11	CHEBI:36976	5032	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Structure and ligand-binding site characteristics of the human P2Y11 nucleotide receptor deduced from computational modelling and mutational analysis .
10821429	0	nucleotide	87,97	P2Y2	82,86	nucleotide	P2Y2	CHEBI:36976	5029	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Mechanisms of agonist-dependent and - independent desensitization of a recombinant P2Y2 nucleotide receptor .
10839197	0	nucleotide	53,63	P2Y2	48,52	nucleotide	P2Y2	CHEBI:36976	5029	Chemical	Gene	START_ENTITY|nsubj|desensitization desensitization|nmod|END_ENTITY	Differential agonist-induced desensitization of P2Y2 nucleotide receptors by ATP and UTP .
12714597	0	nucleotide	9,19	P2Y2	4,8	nucleotide	P2Y2	CHEBI:36976	5029	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	The P2Y2 nucleotide receptor mediates UTP-induced vascular_cell_adhesion_molecule-1 expression in coronary artery endothelial cells .
15924261	0	nucleotide	30,40	P2Y2	25,29	nucleotide	P2Y2	CHEBI:36976	29597(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY receptor|nummod|END_ENTITY	Endocytosis mechanism of P2Y2 nucleotide receptor tagged with green fluorescent protein : clathrin and actin cytoskeleton dependence .
15953819	0	nucleotide	31,41	P2Y2	26,30	nucleotide	P2Y2	CHEBI:36976	5029	Chemical	Gene	function|amod|START_ENTITY function|compound|END_ENTITY	Molecular determinants of P2Y2 nucleotide receptor function : implications for proliferative and inflammatory pathways in astrocytes .
16311903	0	nucleotide	64,74	P2Y2	59,63	nucleotide	P2Y2	CHEBI:36976	5029	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Agonist-induced phosphorylation and desensitization of the P2Y2 nucleotide receptor .
18506388	0	nucleotide	23,33	P2Y2	18,22	nucleotide	P2Y2	D009711	5029	Chemical	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Selective loss of P2Y2 nucleotide receptor immunoreactivity is associated with Alzheimer 's _ disease_neuropathology .
25088742	0	nucleotide	5,15	P2Y2	0,4	nucleotide	P2Y2	CHEBI:36976	18442(Tax:10090)	Chemical	Gene	mediates|compound|START_ENTITY mediates|compound|END_ENTITY	P2Y2 nucleotide receptor mediates arteriogenesis in a murine model of hind limb ischemia .
9023342	0	nucleotide	32,42	P2Y2	27,31	nucleotide	P2Y2	CHEBI:36976	18442(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Transient up-regulation of P2Y2 nucleotide receptor mRNA expression is an immediate early gene response in activated thymocytes .
9222539	0	nucleotide	44,54	P2Y2	39,43	nucleotide	P2Y2	CHEBI:36976	29597(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Inhibition by heterologously-expressed P2Y2 nucleotide receptors of N-type calcium currents in rat sympathetic neurones .
9316432	0	nucleotide	21,31	P2Y2	16,20	nucleotide	P2Y2	CHEBI:36976	29597(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Upregulation Upregulation|nmod|END_ENTITY	Upregulation of P2Y2 nucleotide receptors in rat salivary gland cells during short-term culture .
9651200	0	nucleotide	5,15	P2Y2	0,4	nucleotide	P2Y2	CHEBI:36976	29597(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|nummod|END_ENTITY	P2Y2 nucleotide receptors expressed heterologously in sympathetic neurons inhibit both N-type Ca2 + and M-type K + currents .
9730959	0	nucleotide	32,42	P2Y2	27,31	nucleotide	P2Y2	CHEBI:36976	5029	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|retinoids retinoids|nmod|END_ENTITY	Regulation by retinoids of P2Y2 nucleotide receptor mRNA in human uterine cervical cells .
9778415	0	nucleotide	45,55	P2Y2	40,44	nucleotide	P2Y2	CHEBI:36976	5029	Chemical	Gene	receptors|amod|START_ENTITY receptors|nummod|END_ENTITY	Regulation of ocular mucin secretion by P2Y2 nucleotide receptors in rabbit and human conjunctiva .
9792648	0	nucleotide	82,92	P2Y2	77,81	nucleotide	P2Y2	CHEBI:36976	5029	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Structural basis of agonist-induced desensitization and sequestration of the P2Y2 nucleotide receptor .
11290369	0	nucleotide	57,67	P2Y4	52,56	nucleotide	P2Y4	CHEBI:36976	57385(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|cloning cloning|nmod|END_ENTITY	Molecular cloning and characterization of the mouse P2Y4 nucleotide receptor .
9647463	0	nucleotide	51,61	P2Y4	46,50	nucleotide	P2Y4	CHEBI:36976	5030	Chemical	Gene	receptor|compound|START_ENTITY receptor|nummod|END_ENTITY	Molecular cloning and characterization of rat P2Y4 nucleotide receptor .
10068202	0	nucleotide	29,39	P2Y6	24,28	nucleotide	P2Y6	CHEBI:36976	5031	Chemical	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of the human P2Y6 nucleotide receptor in normal placenta and gestational_trophoblastic_disease .
10193782	0	nucleotide	51,61	P2Y6	46,50	nucleotide	P2Y6	CHEBI:36976	117264(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY END_ENTITY|dobj|receptors	Dual coupling of heterologously-expressed rat P2Y6 nucleotide receptors to N-type Ca2 + and M-type K + currents in rat sympathetic neurones .
12825835	0	nucleotide	5,15	P2Y6	0,4	nucleotide	P2Y6	CHEBI:36976	5031	Chemical	Gene	receptor|amod|START_ENTITY receptor|nummod|END_ENTITY	P2Y6 nucleotide receptor activates PKC to protect 1321N1 astrocytoma cells against tumor necrosis factor-induced apoptosis .
15722352	0	nucleotide	5,15	P2Y6	0,4	nucleotide	P2Y6	CHEBI:36976	117264(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	P2Y6 nucleotide receptors activate NF-kappaB and increase survival of osteoclasts .
9009303	8	nucleotide	1089,1099	P39	1116,1119	nucleotide	P39	CHEBI:36976	282148(Tax:9913)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|gene gene|compound|END_ENTITY	The nucleotide sequence of the P39 gene was determined , and the deduced amino_acid sequence is in accordance with the sequence of an internal peptide isolated from P39 .
25479941	0	nucleotide	30,40	P53	58,61	nucleotide	P53	CHEBI:36976	7157	Chemical	Gene	association|nmod|START_ENTITY polymorphisms|nsubj|association polymorphisms|nmod|pathway pathway|compound|END_ENTITY	Genetic association of single nucleotide polymorphisms in P53 pathway with gastric_cancer risk in a Chinese Han population .
22490479	0	nucleotide	41,51	PARK15	80,86	nucleotide	PARK15	CHEBI:36976	25793	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Lack of association between three single nucleotide polymorphisms in the PARK9 , PARK15 , and BST1 genes and Parkinson 's _ disease in the northern Han Chinese population .
24361882	0	nucleotide	87,97	PB1	80,83	nucleotide	PB1	CHEBI:36976	55193	Chemical	Gene	recognition|amod|START_ENTITY END_ENTITY|nmod|recognition	Involvement of the N-terminal portion of influenza virus RNA polymerase subunit PB1 in nucleotide recognition .
26108738	0	nucleotide	13,23	PDCD1	0,5	nucleotide	PDCD1	D009711	5133	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nummod|END_ENTITY	PDCD1 single nucleotide genes polymorphisms confer susceptibility to juvenile-onset systemic_lupus_erythematosus .
25362542	0	nucleotide	7,17	PDCD6	35,40	nucleotide	PDCD6	CHEBI:36976	10016	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Single nucleotide polymorphisms in PDCD6 gene are associated with the development of cervical_squamous_cell_carcinoma .
15901640	0	nucleotide	70,80	PDE1A	35,40	nucleotide	PDE1A	CHEBI:36976	18573(Tax:10090)	Chemical	Gene	phosphodiesterase|compound|START_ENTITY phosphodiesterase|compound|END_ENTITY	Identification of a new variant of PDE1A calmodulin-stimulated cyclic nucleotide phosphodiesterase expressed in mouse sperm .
10611481	0	nucleotide	9,19	PDE5	20,24	nucleotide	PDE5	CHEBI:36976	8654	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	A cyclic nucleotide PDE5 inhibitor corrects defective mucin secretion in submandibular cells containing antibody directed against the cystic_fibrosis transmembrane conductance regulator protein .
10872825	0	nucleotide	88,98	PDE7B	52,57	nucleotide	PDE7B	CHEBI:36976	29863(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Cloning Cloning|nmod|END_ENTITY	Cloning and characterization of the human and mouse PDE7B , a novel cAMP-specific cyclic nucleotide phosphodiesterase .
9856478	0	nucleotide	54,64	PDE9A	89,94	nucleotide	PDE9A	CHEBI:36976	5152	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification and characterization of a novel cyclic nucleotide phosphodiesterase gene -LRB- PDE9A -RRB- that maps to 21q22 .3 : alternative splicing of mRNA transcripts , genomic structure and sequence .
6300772	0	nucleotide	4,14	PHO5	37,41	nucleotide	PHO5	CHEBI:36976	852390(Tax:4932)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|gene gene|compound|END_ENTITY	The nucleotide sequence of the yeast PHO5 gene : a putative precursor of repressible acid phosphatase contains a signal peptide .
23976970	0	nucleotide	7,17	PIN1	35,39	nucleotide	PIN1	CHEBI:36976	5300	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|region region|amod|END_ENTITY	Single nucleotide polymorphisms of PIN1 promoter region and cancer risk : evidence from a meta-analysis .
24148949	0	nucleotide	28,38	PON2	56,60	nucleotide	PON2	CHEBI:36976	5445	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	-LSB- Association between single nucleotide polymorphisms of PON2 gene and susceptibility to occupational noise-induced deafness among Chinese Han population exposed to high noise levels -RSB- .
16804087	0	nucleotide	7,17	PPARD	35,40	nucleotide	PPARD	CHEBI:36976	5467	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Single nucleotide polymorphisms of PPARD in combination with the Gly482Ser substitution of PGC-1A and the Pro12Ala substitution of PPARG2 predict the conversion from impaired_glucose_tolerance to type 2 diabetes : the STOP-NIDDM trial .
18941885	0	nucleotide	11,21	PRDM9	39,44	nucleotide	PRDM9	CHEBI:36976	56979	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Two single nucleotide polymorphisms in PRDM9 -LRB- MEISETZ -RRB- gene may be a genetic risk factor for Japanese patients with azoospermia by meiotic_arrest .
22496757	0	nucleotide	7,17	PRDX3	39,44	nucleotide	PRDX3	D009711	10935	Chemical	Gene	START_ENTITY|dobj|polymorphisms polymorphisms|nmod|END_ENTITY	Single nucleotide polymorphisms in the PRDX3 and RPS19 and risk of HPV persistence and cervical precancer/cancer .
12905622	0	nucleotide	31,41	PRKCZ	59,64	nucleotide	PRKCZ	CHEBI:36976	5590	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	-LSB- The association of two single nucleotide polymorphisms in PRKCZ and UTS2 respectively with type 2 diabetes in Han people of northern China -RSB- .
15943782	0	nucleotide	7,17	PRNP	59,63	nucleotide	PRNP	CHEBI:36976	494014(Tax:9823)	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|appos|END_ENTITY	Single nucleotide polymorphisms of the prion_protein gene -LRB- PRNP -RRB- in Chinese pig breeds .
15525646	0	nucleotide	55,65	Pim-1	88,93	nucleotide	Pim-1	CHEBI:36976	5292	Chemical	Gene	mode|amod|START_ENTITY mode|nmod|END_ENTITY	Structural basis of constitutive activity and a unique nucleotide binding mode of human Pim-1 kinase .
11788722	0	nucleotide	113,123	RAD23	107,112	nucleotide	RAD23	CHEBI:36976	856674(Tax:4932)	Chemical	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	Involvement of rhp23 , a Schizosaccharomyces_pombe homolog of the human HHR23A and Saccharomyces_cerevisiae RAD23 nucleotide excision repair genes , in cell cycle control and protein ubiquitination .
16520463	0	nucleotide	7,17	RAD54L	42,48	nucleotide	RAD54L	CHEBI:36976	8438	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Single nucleotide polymorphisms of RecQ1 , RAD54L , and ATM genes are associated with reduced survival of pancreatic_cancer .
24295637	0	nucleotide	18,28	RASSF3	50,56	nucleotide	RASSF3	CHEBI:36976	283349	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Functional single nucleotide polymorphisms of the RASSF3 gene and susceptibility to squamous_cell_carcinoma_of_the_head_and_neck .
16877807	0	nucleotide	7,17	RET	39,42	nucleotide	RET	CHEBI:36976	5979	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Single nucleotide polymorphisms in the RET gene and their correlations with Hirschsprung_disease phenotype .
15807543	0	nucleotide	47,57	RGS14	18,23	nucleotide	RGS14	CHEBI:36976	10636	Chemical	Gene	START_ENTITY|nsubj|activity activity|nmod|END_ENTITY	Novel activity of RGS14 on Goalpha and Gialpha nucleotide binding and hydrolysis distinct from its RGS domain and GDI activity .
8623538	0	nucleotide	13,23	RNA1	61,65	nucleotide	RNA1	CHEBI:36976	963865(Tax:12466)	Chemical	Gene	sequence|compound|START_ENTITY sequence|nmod|END_ENTITY	The complete nucleotide sequence of barley_mild_mosaic_virus RNA1 and its relationship with other members of the Potyviridae .
7559571	0	nucleotide	39,49	Rad1	12,16	nucleotide	Rad1	CHEBI:36976	856085(Tax:4932)	Chemical	Gene	repair|amod|START_ENTITY Role|nmod|repair Role|nmod|END_ENTITY	Role of the Rad1 and Rad10 proteins in nucleotide excision repair and recombination .
18936173	0	nucleotide	49,59	Rad4p	29,34	nucleotide	Rad4p	CHEBI:36976	856909(Tax:4932)	Chemical	Gene	repair|amod|START_ENTITY roles|nmod|repair roles|nmod|END_ENTITY	Complementary roles of yeast Rad4p and Rad34p in nucleotide excision repair of active and inactive rRNA gene chromatin .
11916875	0	nucleotide	44,54	RecA	66,70	nucleotide	RecA	CHEBI:36976	5888	Chemical	Gene	START_ENTITY|amod|binding binding|nmod|END_ENTITY	Investigating structural changes induced by nucleotide binding to RecA using difference FTIR .
8487759	0	nucleotide	79,89	RecA	95,99	nucleotide	RecA	CHEBI:36976	5888	Chemical	Gene	START_ENTITY|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- The role of oligophosphate and nucleoside fragments upon the interaction of a nucleotide with RecA protein -RSB- .
8113731	0	nucleotide	95,105	S10	133,136	nucleotide	S10	CHEBI:36976	6204	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Cloning of the Nilaparvata_lugens_reovirus genome : conserved terminal nucleotide sequences and nucleotide sequence of genome segment S10 .
18280297	0	nucleotide	18,28	SALL1	50,55	nucleotide	SALL1	CHEBI:36976	6299	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Two coding single nucleotide polymorphisms in the SALL1 gene in Townes-Brocks_syndrome : a case report and review of the literature .
22116646	0	nucleotide	7,17	SEPTIN12	39,47	nucleotide	SEPTIN12	CHEBI:36976	124404	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Single nucleotide polymorphisms in the SEPTIN12 gene may be associated with azoospermia by meiotic_arrest in Japanese men .
25635986	0	nucleotide	7,17	SHIP2	35,40	nucleotide	SHIP2	D009711	3636	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Single nucleotide polymorphisms on SHIP2 is associated with Type_2_diabetes_mellitus in Chinese Han population .
23839864	0	nucleotide	46,56	SIRT3	33,38	nucleotide	SIRT3	D009711	23410	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nummod|END_ENTITY	Modulation of human longevity by SIRT3 single nucleotide polymorphisms in the prospective study `` Treviso Longeva -LRB- TRELONG -RRB- '' .
26674735	0	nucleotide	7,17	SLC22A2	39,46	nucleotide	SLC22A2	D009711	6582	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Single nucleotide polymorphisms of the SLC22A2 gene within the Xhosa population of South Africa .
22509097	0	nucleotide	54,64	SLC2A1	40,46	nucleotide	SLC2A1	CHEBI:36976	6513	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nummod|END_ENTITY	Multicenter cohort association study of SLC2A1 single nucleotide polymorphisms and age-related macular_degeneration .
20858712	0	nucleotide	34,44	SLC30A2	62,69	nucleotide	SLC30A2	CHEBI:36976	7780	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Functional analysis of two single nucleotide polymorphisms in SLC30A2 -LRB- ZnT2 -RRB- : implications for mammary gland function and breast_disease in women .
16758257	0	nucleotide	22,32	SLCO1B1	108,115	nucleotide	SLCO1B1	CHEBI:36976	10599	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Frequencies of single nucleotide polymorphisms and haplotypes of organic_anion_transporting_polypeptide_1B1 SLCO1B1 gene in a Finnish population .
26373210	0	nucleotide	18,28	SLCO1B1	65,72	nucleotide	SLCO1B1	D009711	10599	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Effects of single nucleotide polymorphisms and haplotypes of the SLCO1B1 gene on the pharmacokinetic profile of atorvastatin in healthy Macedonian volunteers .
10339583	0	nucleotide	9,19	SMN	27,30	nucleotide	SMN	CHEBI:36976	6606	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	A single nucleotide in the SMN gene regulates splicing and is responsible for spinal_muscular_atrophy .
18582155	0	nucleotide	22,32	SOD2	50,54	nucleotide	SOD2	CHEBI:36976	6648	Chemical	Gene	Association|nmod|START_ENTITY polymorphisms|nsubj|Association polymorphisms|nmod|END_ENTITY	Association of single nucleotide polymorphisms in SOD2 , XRCC1 and XRCC3 with susceptibility for the development of adverse effects resulting from radiotherapy for prostate_cancer .
23065270	0	nucleotide	13,23	SREBP1	48,54	nucleotide	SREBP1	CHEBI:36976	539361(Tax:9913)	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Novel single nucleotide polymorphisms of bovine SREBP1 gene is association with fatty_acid composition and marbling score in commercial Korean cattle -LRB- Hanwoo -RRB- .
24204993	0	nucleotide	7,17	STING	41,46	nucleotide	STING	CHEBI:36976	340061	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Single nucleotide polymorphisms of human STING can affect innate immune response to cyclic_dinucleotides .
16011022	0	nucleotide	60,70	STK15	88,93	nucleotide	STK15	CHEBI:36976	6790	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Linkage disequilibrium and haplotype analysis of two single nucleotide polymorphisms in STK15 in Chinese .
23358261	0	nucleotide	7,17	SULT1A1	35,42	nucleotide	SULT1A1	CHEBI:36976	6817	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Single nucleotide polymorphisms in SULT1A1 and SULT1A2 in a Korean population .
3526282	0	nucleotide	41,51	SUP1	27,31	nucleotide	SUP1	CHEBI:36976	852440(Tax:4932)	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|dep|sequence	Yeast omnipotent supressor SUP1 -LRB- SUP45 -RRB- : nucleotide sequence of the wildtype and a mutant gene .
18421459	0	nucleotide	97,107	Sls1	92,96	nucleotide	Sls1	CHEBI:36976	850830(Tax:4932)	Chemical	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	Characterization of Ire1 in the yeast Yarrowia_lipolytica reveals an important role for the Sls1 nucleotide exchange factor in unfolded protein response regulation .
19323566	0	nucleotide	68,78	Sos1	63,67	nucleotide	Sos1	CHEBI:36976	6654	Chemical	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	SH3 domains of Grb2 adaptor bind to PXpsiPXR motifs within the Sos1 nucleotide exchange factor in a discriminate manner .
17132105	0	nucleotide	16,26	Ssb1p	91,96	nucleotide	Ssa1p	CHEBI:36976	851259(Tax:4932)	Chemical	Gene	factor|amod|START_ENTITY factor|nmod|END_ENTITY	Fes1p acts as a nucleotide exchange factor for the ribosome-associated molecular chaperone Ssb1p .
11254136	0	nucleotide	32,42	Ste6	82,86	nucleotide	Ste6	CHEBI:36976	853671(Tax:4932)	Chemical	Gene	START_ENTITY|dobj|domains domains|nmod|END_ENTITY	Functional asymmetry of the two nucleotide binding domains in the ABC transporter Ste6 .
14622282	0	nucleotide	13,23	TAP	94,97	nucleotide	TAP	CHEBI:36976	6890	Chemical	Gene	states|amod|START_ENTITY states|nmod|transporter_associated_with_antigen_processing transporter_associated_with_antigen_processing|appos|END_ENTITY	The distinct nucleotide binding states of the transporter_associated_with_antigen_processing -LRB- TAP -RRB- are regulated by the nonhomologous C-terminal tails of TAP1 and TAP2 .
23300827	0	nucleotide	22,32	TCF2	50,54	nucleotide	TCF2	CHEBI:36976	6928	Chemical	Gene	Association|nmod|START_ENTITY polymorphisms|nsubj|Association polymorphisms|nmod|END_ENTITY	Association of single nucleotide polymorphisms in TCF2 with type_2_diabetes susceptibility in a Han Chinese population .
17003358	0	nucleotide	14,24	TCF7L2	42,48	nucleotide	TCF7L2	CHEBI:36976	6934	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals .
21423583	0	nucleotide	7,17	TCF7L2	35,41	nucleotide	TCF7L2	CHEBI:36976	6934	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Single nucleotide polymorphisms of TCF7L2 are linked to diabetic coronary_atherosclerosis .
26581115	0	nucleotide	9,19	TDP-43	20,26	nucleotide	TDP-43	D009711	23435	Chemical	Gene	mutation|amod|START_ENTITY mutation|compound|END_ENTITY	A single nucleotide TDP-43 mutation within a Taiwanese family : A multifaceted demon .
11673833	0	nucleotide	9,19	TGF-betaRII	43,54	nucleotide	TGF-betaRII	CHEBI:36976	7048	Chemical	Gene	START_ENTITY|nmod|gene gene|amod|END_ENTITY	Abnormal nucleotide repeat sequence in the TGF-betaRII gene in hepatocellular_carcinoma and in uninvolved liver tissue .
16966185	0	nucleotide	70,80	TGFB1	98,103	nucleotide	TGFB1	CHEBI:36976	7040	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Risk of radiation-induced subcutaneous fibrosis in relation to single nucleotide polymorphisms in TGFB1 , SOD2 , XRCC1 , XRCC3 , APEX and ATM -- a study based on DNA from formalin fixed paraffin embedded tissue samples .
17689884	0	nucleotide	13,23	TGFB1	0,5	nucleotide	TGFB1	CHEBI:36976	7040	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nummod|END_ENTITY	TGFB1 single nucleotide polymorphisms are associated with adverse quality of life in prostate_cancer patients treated with radiotherapy .
21258099	0	nucleotide	7,17	TLR9	35,39	nucleotide	TLR9	CHEBI:36976	54106	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Single nucleotide polymorphisms in TLR9 are highly associated with susceptibility to bacterial_meningitis in children .
24884566	0	nucleotide	7,17	TNFAIP3	35,42	nucleotide	TNFAIP3	CHEBI:36976	7128	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Single nucleotide polymorphisms in TNFAIP3 were associated with the risks of rheumatoid_arthritis in northern Chinese Han population .
26846592	0	nucleotide	7,17	TNFAIP3	35,42	nucleotide	TNFAIP3	D009711	7128	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Single nucleotide polymorphisms of TNFAIP3 are associated with systemic_lupus_erythematosus in Han Chinese population .
26992170	0	nucleotide	92,102	TNFRSF1A	103,111	nucleotide	TNFRSF1A	D009711	7132	Chemical	Gene	deletion|compound|START_ENTITY deletion|compound|END_ENTITY	TNF Receptor Associated Periodic Syndrome associated with gonosomal mosaicism of a novel 24 nucleotide TNFRSF1A deletion .
16221758	0	nucleotide	7,17	TNFSF15	35,42	nucleotide	TNFSF15	CHEBI:36976	9966	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn 's _ disease .
19381347	0	nucleotide	7,17	TNMD	57,61	nucleotide	TNMD	CHEBI:36976	64102	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|appos|END_ENTITY	Single nucleotide polymorphisms of the tenomodulin_gene -LRB- TNMD -RRB- in age-related_macular_degeneration .
3017975	0	nucleotide	13,23	TOP2	56,60	nucleotide	TOP2	CHEBI:36976	855636(Tax:4932)	Chemical	Gene	sequence|compound|START_ENTITY sequence|nmod|END_ENTITY	The complete nucleotide sequence of the structural gene TOP2 of yeast DNA topoisomerase II .
26414189	0	nucleotide	7,17	TP53	35,39	nucleotide	TP53	D009711	7157	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Single nucleotide polymorphisms in TP53 but not KRAS or MDM2 are predictive of clinical outcome in multiple_myeloma treated with high-dose melphalan and autologous stem cell support .
26416416	0	nucleotide	21,31	TP53	0,4	nucleotide	TP53	D009711	7157	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nummod|END_ENTITY	TP53 and MDM2 single nucleotide polymorphisms influence survival in non-del -LRB- 5q -RRB- myelodysplastic_syndromes .
22913730	0	nucleotide	11,21	TSLP	39,43	nucleotide	TSLP	CHEBI:36976	85480	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Two single nucleotide polymorphisms in TSLP gene are associated with asthma susceptibility in Chinese Han population .
17215295	0	nucleotide	41,51	Tfb2	20,24	nucleotide	Tfb2	CHEBI:36976	855981(Tax:4932)	Chemical	Gene	START_ENTITY|nsubj|interacts interacts|nmod|END_ENTITY	Tfb5 interacts with Tfb2 and facilitates nucleotide excision repair in yeast .
10835422	0	nucleotide	20,30	Tiam1	14,19	nucleotide	Tiam1	CHEBI:36976	7074	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of Tiam1 nucleotide exchange activity by pleckstrin domain binding ligands .
22205660	0	nucleotide	7,17	Toll-like_receptor_3	39,59	nucleotide	Toll-like receptor 3	CHEBI:36976	7098	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|genes genes|compound|END_ENTITY	Single nucleotide polymorphisms in the Toll-like_receptor_3 and CD44 genes are associated with persistence of vaccine-induced immunity to the serogroup C meningococcal conjugate vaccine .
26965008	0	nucleotide	7,17	UCP2	81,85	nucleotide	UCP2	D009711	7351	Chemical	Gene	polymorphisms|compound|START_ENTITY linked|nsubj|polymorphisms linked|xcomp|mitochondrial mitochondrial|dobj|genes genes|acl:relcl|affect affect|nsubj|END_ENTITY	Single nucleotide polymorphisms linked to mitochondrial uncoupling protein genes UCP2 and UCP3 affect mitochondrial metabolism and healthy aging in female nonagenarians .
17506482	0	nucleotide	37,47	UGT1A1	23,29	nucleotide	UGT1A1	CHEBI:36976	54658	Chemical	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	Rapid detection of the UGT1A1 single nucleotide polymorphism G211A using real-time PCR with Taqman minor groove binder probes .
19881262	0	nucleotide	19,29	UGT1A9	47,53	nucleotide	UGT1A9	CHEBI:36976	54600	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Three novel single nucleotide polymorphisms of UGT1A9 in a Thai population .
26038550	0	nucleotide	31,41	Uncoupling_protein_1	0,20	nucleotide	Uncoupling protein 1	D009711	7350	Chemical	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Uncoupling_protein_1 binds one nucleotide per monomer and is stabilized by tightly bound cardiolipin .
21837802	0	nucleotide	46,56	VDR	78,81	nucleotide	VDR	CHEBI:36976	7421	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Confirmation of an association between single nucleotide polymorphisms in the VDR gene with respiratory_syncytial_virus related disease in South African children .
21378341	0	nucleotide	28,38	VEGF	62,66	nucleotide	VEGF	CHEBI:36976	7422	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Associations between single nucleotide polymorphisms of MMP2 , VEGF , and HIF1A genes and the risk of developing colorectal_cancer .
25550863	0	nucleotide	7,17	VEGF	35,39	nucleotide	VEGF	CHEBI:36976	7422	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Single nucleotide polymorphisms in VEGF gene are associated with an increased risk of osteosarcoma .
1480518	0	nucleotide	8,18	VIP	33,36	nucleotide	VIP	CHEBI:36976	117064(Tax:10116)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Guanine nucleotide regulation of VIP binding to rat peritoneal macrophage membranes .
2086766	0	nucleotide	34,44	VIP	66,69	nucleotide	VIP	CHEBI:36976	117064(Tax:10116)	Chemical	Gene	responses|compound|START_ENTITY Mechanical|dobj|responses Mechanical|xcomp|peptide peptide|dobj|stimulation stimulation|compound|END_ENTITY	Mechanical , electrical and cyclic nucleotide responses to peptide VIP and inhibitory nerve stimulation in rat stomach .
18680536	0	nucleotide	58,68	VKORC1	86,92	nucleotide	VKORC1	CHEBI:36976	79001	Chemical	Gene	substitutions|amod|START_ENTITY substitutions|nmod|END_ENTITY	Pharmacodynamic resistance to warfarin is associated with nucleotide substitutions in VKORC1 .
25390694	0	nucleotide	7,17	VPAC-1	48,54	nucleotide	VPAC-1	CHEBI:36976	7433	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Single nucleotide polymorphisms in the 3 ` UTR of VPAC-1 cooperate in modulating gene expression and impact differently on the interaction with miR525-5p .
25744365	0	nucleotide	7,17	VTI1A	35,40	nucleotide	VTI1A	D009711	143187	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Single nucleotide polymorphisms in VTI1A gene contribute to the susceptibility of Chinese population to non-small cell lung_cancer .
10848823	0	nucleotide	36,46	VWF	83,86	nucleotide	VWF	CHEBI:36976	7450	Chemical	Gene	region|amod|START_ENTITY region|appos|END_ENTITY	A single nucleotide polymorphism at nucleotide -1793 in the von_Willebrand factor -LRB- VWF -RRB- regulatory region is associated with plasma VWF : Ag levels .
21765461	0	nucleotide	34,44	Vav3	29,33	nucleotide	Vav3	CHEBI:36976	10451	Chemical	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	A novel nuclear role for the Vav3 nucleotide exchange factor in androgen_receptor coactivation in prostate_cancer .
18693251	0	nucleotide	78,88	XPA	143,146	nucleotide	XPA	CHEBI:36976	7507	Chemical	Gene	A|amod|START_ENTITY A|appos|END_ENTITY	RecQ4 facilitates UV light-induced DNA damage repair through interaction with nucleotide excision repair factor xeroderma_pigmentosum group A -LRB- XPA -RRB- .
23746523	0	nucleotide	71,81	XPA	60,63	nucleotide	XPA	CHEBI:36976	7507	Chemical	Gene	excision|amod|START_ENTITY END_ENTITY|nmod|excision	Conformational determinants for the recruitment of ERCC1 by XPA in the nucleotide excision repair -LRB- NER -RRB- Pathway : structure and dynamics of the XPA binding motif .
16646069	0	nucleotide	41,51	XPD	37,40	nucleotide	XPD	CHEBI:36976	2068	Chemical	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	Genetic polymorphisms of the XPG and XPD nucleotide excision repair genes in sarcoma patients .
21452186	0	nucleotide	37,47	XPF	22,25	nucleotide	XPF	CHEBI:36976	2072	Chemical	Gene	repair|amod|START_ENTITY Role|nmod|repair Role|nmod|END_ENTITY	Role of endonucleases XPF and XPG in nucleotide excision repair of platinated DNA and cisplatin/oxaliplatin cytotoxicity .
12494477	0	nucleotide	7,17	XPG	39,42	nucleotide	XPG	CHEBI:36976	2073	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Single nucleotide polymorphisms in the XPG gene : determination of role in DNA repair and breast_cancer risk .
15990020	0	nucleotide	130,140	XRCC1	158,163	nucleotide	XRCC1	CHEBI:36976	7515	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Radiation-induced damage to normal tissues after radiotherapy in patients treated for gynecologic tumors : association with single nucleotide polymorphisms in XRCC1 , XRCC3 , and OGG1 genes and in vitro chromosomal radiosensitivity in lymphocytes .
19073198	0	nucleotide	7,17	XRCC1	52,57	nucleotide	XRCC1	CHEBI:36976	7515	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Single nucleotide polymorphisms in DNA repair genes XRCC1 and APEX1 in progression and survival of primary cutaneous_melanoma patients .
3013870	0	nucleotide	23,33	actin	87,92	nucleotide	actin	CHEBI:36976	396526(Tax:9031)	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|nsubj|sequence	Structure and complete nucleotide sequence of the chicken alpha-smooth muscle -LRB- aortic -RRB- actin gene .
8179938	0	nucleotide	18,28	acylase	51,58	nucleotide	acylase	CHEBI:36976	95	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|gene gene|compound|END_ENTITY	-LSB- Localization and nucleotide sequence of propionyl acylase gene of Streptomyces mycarofaciens -RSB- .
17712123	0	nucleotide	7,17	adiponectin	39,50	nucleotide	adiponectin	CHEBI:36976	9370	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Single nucleotide polymorphisms at the adiponectin locus and risk of coronary_heart_disease in men and women .
23698590	0	nucleotide	32,42	adiponectin	64,75	nucleotide	adiponectin	CHEBI:36976	9370	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Associations between two single nucleotide polymorphisms of the adiponectin gene , its circulating concentrations and cardiometabolic risk factors in prepubertal children with and without abdominal_obesity .
23661018	0	nucleotide	25,35	agouti_signaling_protein	57,81	nucleotide	agouti signaling protein	CHEBI:36976	100860915	Chemical	Gene	Identification|nmod|START_ENTITY polymorphisms|nsubj|Identification polymorphisms|nmod|gene gene|amod|END_ENTITY	Identification of single nucleotide polymorphisms in the agouti_signaling_protein -LRB- ASIP -RRB- gene in some goat breeds in tropical and temperate climates .
25100243	0	nucleotide	63,73	alkaline_sphingomyelinase	36,61	nucleotide	alkaline sphingomyelinase	CHEBI:36976	339221	Chemical	Gene	activity|dep|START_ENTITY activity|nmod|END_ENTITY	Changes of activity and isoforms of alkaline_sphingomyelinase -LRB- nucleotide pyrophosphatase phosphodiesterase 7 -RRB- in bile from patients undergoing endoscopic retrograde cholangiopancreatography .
3014515	0	nucleotide	29,39	alpha-galactosidase_A	6,27	nucleotide	alpha-galactosidase A	CHEBI:36976	2717	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|dep|sequence	Human alpha-galactosidase_A : nucleotide sequence of a cDNA clone encoding the mature enzyme .
10806244	0	nucleotide	46,56	alpha-glucosidase	94,111	nucleotide	alpha-glucosidase	CHEBI:36976	100313963(Tax:4513)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Purification , enzymatic characterization , and nucleotide sequence of a high-isoelectric-point alpha-glucosidase from barley malt .
8357837	0	nucleotide	4,14	aminoacylase-1	33,47	nucleotide	aminoacylase-1	CHEBI:36976	95	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The nucleotide sequence of human aminoacylase-1 .
16572495	0	nucleotide	7,17	apoM	90,94	nucleotide	apoM	CHEBI:36976	55937	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|appos|END_ENTITY	Single nucleotide polymorphisms in the proximal promoter region of apolipoprotein_M gene -LRB- apoM -RRB- confer the susceptibility to development of type_2_diabetes in Han Chinese .
6089788	0	nucleotide	27,37	apolipoprotein_A-II	6,25	nucleotide	apolipoprotein A-II	CHEBI:36976	336	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|dep|sequence	Human apolipoprotein_A-II : nucleotide sequence of a cloned cDNA , and localization of its structural gene on human chromosome 1 .
2351649	0	nucleotide	67,77	apolipoprotein_A-IV	99,118	nucleotide	apolipoprotein A-IV	CHEBI:36976	337	Chemical	Gene	START_ENTITY|nmod|gene gene|amod|END_ENTITY	Genetic polymorphism of human plasma apolipoprotein_A-IV is due to nucleotide substitutions in the apolipoprotein_A-IV gene .
15453913	0	nucleotide	7,17	apolipoprotein_B	39,55	nucleotide	apolipoprotein B	CHEBI:36976	338	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|genes genes|compound|END_ENTITY	Single nucleotide polymorphisms in the apolipoprotein_B and low_density_lipoprotein_receptor genes affect response to antihypertensive treatment .
25286669	0	nucleotide	7,17	arylsulfatase_D	38,53	nucleotide	arylsulfatase D	CHEBI:36976	414	Chemical	Gene	polymorphism|compound|START_ENTITY polymorphism|nmod|gene gene|amod|END_ENTITY	Single nucleotide polymorphism within arylsulfatase_D gene -LRB- ARSD -RRB- is associated with selected kinematic parameters of sperm motility in Holstein-Friesian bulls .
25196645	0	nucleotide	7,17	ataxia_telangiectasia_mutated	35,64	nucleotide	ataxia telangiectasia mutated	CHEBI:36976	472	Chemical	Gene	START_ENTITY|dobj|polymorphisms polymorphisms|nmod|END_ENTITY	Single nucleotide polymorphisms of ataxia_telangiectasia_mutated and the risk of papillary_thyroid_carcinoma .
6324080	0	nucleotide	4,14	beta-actin	49,59	nucleotide	beta-actin	CHEBI:36976	396526(Tax:9031)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|gene gene|compound|END_ENTITY	The nucleotide sequence of the chick cytoplasmic beta-actin gene .
2546004	0	nucleotide	124,134	beta-ketothiolase	75,92	nucleotide	beta-ketothiolase	CHEBI:36976	30	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|dep|sequence	Fine structural analysis of the Zoogloea ramigera phbA-phbB locus encoding beta-ketothiolase and acetoacetyl-CoA reductase : nucleotide sequence of phbB .
6322135	0	nucleotide	21,31	c-mos	9,14	nucleotide	c-mos	CHEBI:36976	24559(Tax:10116)	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|dep|sequence	Complete c-mos -LRB- rat -RRB- nucleotide sequence : presence of conserved domains in c-mos proteins .
2822504	0	nucleotide	23,33	calmodulin	99,109	nucleotide	calmodulin	CHEBI:36976	100682497	Chemical	Gene	Activation|nmod|START_ENTITY kinase|nsubj|Activation kinase|nmod|END_ENTITY	Activation of a cyclic nucleotide phosphodiesterase and of a protein kinase by chemically modified calmodulin .
19420965	0	nucleotide	7,17	cannabinoid_receptor-1	32,54	nucleotide	cannabinoid receptor-1	CHEBI:36976	1268	Chemical	Gene	START_ENTITY|nmod|gene gene|amod|END_ENTITY	Single nucleotide change in the cannabinoid_receptor-1 -LRB- CNR1 -RRB- gene in colorectal_cancer outcome .
2496681	0	nucleotide	30,40	carbonic_anhydrase_III	6,28	nucleotide	carbonic anhydrase III	CHEBI:36976	12350(Tax:10090)	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|dep|sequence	Mouse carbonic_anhydrase_III : nucleotide sequence and expression studies .
19204081	0	nucleotide	25,35	carbonyl_reductase_1	59,79	nucleotide	carbonyl reductase 1	CHEBI:36976	873	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Two nonsynonymous single nucleotide polymorphisms of human carbonyl_reductase_1 demonstrate reduced in vitro metabolism of daunorubicin and doxorubicin .
6284174	0	nucleotide	33,43	casein_kinase	79,92	nucleotide	casein kinase	CHEBI:36976	149420	Chemical	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	Selective inhibition of a cyclic nucleotide independent protein kinase -LRB- G type casein_kinase -RRB- by quercetin and related polyphenols .
15794635	0	nucleotide	2,12	caspase-9	29,38	nucleotide	caspase-9	CHEBI:36976	842	Chemical	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	A nucleotide binding site in caspase-9 regulates apoptosome activation .
6278942	0	nucleotide	7,17	cholecystokinin	33,48	nucleotide	cholecystokinin	CHEBI:36976	885	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|nmod|END_ENTITY	Cyclic nucleotide antagonists of cholecystokinin : structural requirements for interaction with the cholecystokinin receptor .
4380667	0	nucleotide	33,43	citrate_synthase	68,84	nucleotide	citrate synthase	CHEBI:36976	397519(Tax:9823)	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Effect of divalent metal ions on nucleotide inhibition of pig heart citrate_synthase .
1550490	0	nucleotide	4,14	coat_protein	31,43	nucleotide	coat protein	CHEBI:36976	64083	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|gene gene|compound|END_ENTITY	The nucleotide sequence of the coat_protein gene and 3 ' untranslated region of papaya_ringspot_virus type W -LRB- Aust -RRB- .
8870274	0	nucleotide	4,14	coat_protein	31,43	nucleotide	coat protein	CHEBI:36976	64083	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|gene gene|compound|END_ENTITY	The nucleotide sequence of the coat_protein gene and 3 ' untranslated region of azuki bean mosaic potyvirus , a member of the bean_common_mosaic_virus subgroup .
7843345	0	nucleotide	23,33	cryptic	50,57	nucleotide	cryptic	CHEBI:36976	55997	Chemical	Gene	sequence|compound|START_ENTITY sequence|nmod|END_ENTITY	Analysis of the entire nucleotide sequence of the cryptic plasmid QpH1 from Coxiella burnetti .
11781328	0	nucleotide	50,60	cyclic_AMP_receptor_protein	72,99	nucleotide	cyclic AMP receptor protein	CHEBI:36976	1401	Chemical	Gene	START_ENTITY|xcomp|binding binding|xcomp|END_ENTITY	Stoichiometry and structural effect of the cyclic nucleotide binding to cyclic_AMP_receptor_protein .
19236532	0	nucleotide	14,24	cyclooxygenase-2	42,58	nucleotide	cyclooxygenase-2	CHEBI:36976	5743	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Common single nucleotide polymorphisms in cyclooxygenase-2 and risk of severe chronic_periodontitis in a Chinese population .
21319995	0	nucleotide	27,37	cyclooxygenase-2	59,75	nucleotide	cyclooxygenase-2	CHEBI:36976	5743	Chemical	Gene	Association|nmod|START_ENTITY polymorphisms|nsubj|Association polymorphisms|nmod|END_ENTITY	Association between single nucleotide polymorphisms in the cyclooxygenase-2 , tumor_necrosis_factor-a , and vascular_endothelial_growth_factor-A genes , and susceptibility to hepatocellular_carcinoma .
11349190	0	nucleotide	178,188	cystathionine_beta-synthase	209,236	nucleotide	cystathionine beta-synthase	CHEBI:36976	875	Chemical	Gene	START_ENTITY|nmod|gene gene|nmod|END_ENTITY	Genetic susceptibility to preeclampsia : roles of cytosineto-thymine substitution at nucleotide 677 of the gene for methylenetetrahydrofolate_reductase , 68-base pair insertion at nucleotide 844 of the gene for cystathionine_beta-synthase , and factor_V_Leiden mutation .
10581360	0	nucleotide	33,43	cystic_fibrosis_transmembrane_conductance_regulator	63,114	nucleotide	cystic fibrosis transmembrane conductance regulator	CHEBI:36976	1080	Chemical	Gene	START_ENTITY|dobj|domains domains|nmod|END_ENTITY	Differential function of the two nucleotide binding domains on cystic_fibrosis_transmembrane_conductance_regulator .
10919864	0	nucleotide	129,139	cystic_fibrosis_transmembrane_conductance_regulator	60,111	nucleotide	cystic fibrosis transmembrane conductance regulator	CHEBI:36976	1080	Chemical	Gene	define|parataxis|START_ENTITY define|dobj|boundaries boundaries|nmod|NH NH|nmod:poss|END_ENTITY	Severed molecules functionally define the boundaries of the cystic_fibrosis_transmembrane_conductance_regulator 's NH -LRB- 2 -RRB- - terminal nucleotide binding domain .
12020354	0	nucleotide	61,71	cystic_fibrosis_transmembrane_conductance_regulator	94,145	nucleotide	cystic fibrosis transmembrane conductance regulator	CHEBI:36976	1080	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Functional analysis of the C-terminal boundary of the second nucleotide binding domain of the cystic_fibrosis_transmembrane_conductance_regulator and structural implications .
15719171	0	nucleotide	93,103	cystic_fibrosis_transmembrane_conductance_regulator	34,85	nucleotide	cystic fibrosis transmembrane conductance regulator	CHEBI:36976	1080	Chemical	Gene	domains|amod|START_ENTITY site|nmod|domains site|nmod|activators activators|nmod|END_ENTITY	Binding site of activators of the cystic_fibrosis_transmembrane_conductance_regulator in the nucleotide binding domains .
19403599	0	nucleotide	21,31	cystic_fibrosis_transmembrane_conductance_regulator	66,117	nucleotide	cystic fibrosis transmembrane conductance regulator	CHEBI:36976	1080	Chemical	Gene	binding|nmod:npmod|START_ENTITY binding|acl|gating gating|nmod|END_ENTITY	Relationship between nucleotide binding and ion channel gating in cystic_fibrosis_transmembrane_conductance_regulator .
20435887	0	nucleotide	14,24	cystic_fibrosis_transmembrane_conductance_regulator	73,124	nucleotide	cystic fibrosis transmembrane conductance regulator	CHEBI:36976	1080	Chemical	Gene	domain|amod|START_ENTITY terminus|nmod|domain contains|nsubj|terminus contains|dobj|features features|nmod|trafficking trafficking|compound|END_ENTITY	C terminus of nucleotide binding domain 1 contains critical features for cystic_fibrosis_transmembrane_conductance_regulator trafficking and activation .
21067729	0	nucleotide	24,34	cystic_fibrosis_transmembrane_conductance_regulator	65,116	nucleotide	cystic fibrosis transmembrane conductance regulator	CHEBI:36976	1080	Chemical	Gene	position|amod|START_ENTITY variant|nmod|position variant|dobj|+11 +11|acl:relcl|induces induces|nsubj|T T|nmod|gene gene|compound|END_ENTITY	Heterozygous variant at nucleotide position 875 +11 A > T in exon 6A cystic_fibrosis_transmembrane_conductance_regulator gene induces 852del22 mutation false-positivity by line probe assay .
22722932	0	nucleotide	81,91	cystic_fibrosis_transmembrane_conductance_regulator	114,165	nucleotide	cystic fibrosis transmembrane conductance regulator	CHEBI:36976	1080	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Conformational changes relevant to channel activity and folding within the first nucleotide binding domain of the cystic_fibrosis_transmembrane_conductance_regulator .
7510695	0	nucleotide	9,19	cystic_fibrosis_transmembrane_conductance_regulator	46,97	nucleotide	cystic fibrosis transmembrane conductance regulator	CHEBI:36976	1080	Chemical	Gene	modulates|compound|START_ENTITY Cl|dep|modulates Cl|compound|END_ENTITY	Pyridine nucleotide redox potential modulates cystic_fibrosis_transmembrane_conductance_regulator Cl - conductance .
8946960	0	nucleotide	56,66	cystic_fibrosis_transmembrane_conductance_regulator	87,138	nucleotide	cystic fibrosis transmembrane conductance regulator	CHEBI:36976	1080	Chemical	Gene	fold|compound|START_ENTITY fold|nmod|END_ENTITY	A recombinant polypeptide model of the second predicted nucleotide binding fold of the cystic_fibrosis_transmembrane_conductance_regulator is a GTP-binding protein .
9822656	0	nucleotide	29,39	cystic_fibrosis_transmembrane_conductance_regulator	59,110	nucleotide	cystic fibrosis transmembrane conductance regulator	CHEBI:36976	1080	Chemical	Gene	domains|amod|START_ENTITY modification|nmod|domains modification|nmod|END_ENTITY	Covalent modification of the nucleotide binding domains of cystic_fibrosis_transmembrane_conductance_regulator .
8526931	0	nucleotide	14,24	cytochrome_C_oxidase	42,62	nucleotide	cytochrome C oxidase	CHEBI:36976	282199(Tax:9913)	Chemical	Gene	sites|amod|START_ENTITY sites|nmod|END_ENTITY	The number of nucleotide binding sites in cytochrome_C_oxidase .
24982938	0	nucleotide	147,157	cytochrome_C_oxidase_subunit_I	116,146	nucleotide	cytochrome C oxidase subunit I	CHEBI:36976	19893533	Chemical	Gene	sequences|compound|START_ENTITY sequences|compound|END_ENTITY	Molecular identification of necrophagous muscidae and sarcophagidae fly species collected in Korea by mitochondrial cytochrome_C_oxidase_subunit_I nucleotide sequences .
21532277	0	nucleotide	52,62	cytochrome_P450_2C9	80,99	nucleotide	cytochrome P450 2C9	CHEBI:36976	1559	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	-LSB- Development of rapid genotyping methods for single nucleotide polymorphisms of cytochrome_P450_2C9 -LRB- CYP2C9 -RRB- and cytochrome_P450_2C19 -LRB- CYP2C19 -RRB- and their clinical application in pediatric patients with epilepsy -RSB- .
6300777	0	nucleotide	4,14	cytoplasmic_beta-actin	35,57	nucleotide	cytoplasmic beta-actin	CHEBI:36976	81822(Tax:10116)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|gene gene|compound|END_ENTITY	The nucleotide sequence of the rat cytoplasmic_beta-actin gene .
15785242	0	nucleotide	12,22	cytotoxic_T-lymphocyte-associated_antigen-4	44,87	nucleotide	cytotoxic T-lymphocyte-associated antigen-4	CHEBI:36976	1493	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|region region|amod|END_ENTITY	CT60 single nucleotide polymorphisms of the cytotoxic_T-lymphocyte-associated_antigen-4 gene region is associated with Graves ' _ disease in an Italian population .
3463993	0	nucleotide	41,51	delta-aminolevulinate_dehydratase	6,39	nucleotide	delta-aminolevulinate dehydratase	CHEBI:36976	210	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|dep|sequence	Human delta-aminolevulinate_dehydratase : nucleotide sequence of a full-length cDNA clone .
26400223	0	nucleotide	35,45	deoxycytidine_kinase	63,83	nucleotide	deoxycytidine kinase	D009711	1633	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	The clinical implication of single nucleotide polymorphisms in deoxycytidine_kinase in chronic_hepatitis_B patients treated with lamivudine .
6308574	0	nucleotide	4,14	dihydrofolate_reductase	54,77	nucleotide	dihydrofolate reductase	CHEBI:36976	13906554	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|gene gene|compound|END_ENTITY	The nucleotide sequence of the trimethoprim-resistant dihydrofolate_reductase gene harbored by Tn7 .
11763189	0	nucleotide	35,45	dystrophin	101,111	nucleotide	dystrophin	CHEBI:36976	606758(Tax:9615)	Chemical	Gene	START_ENTITY|nmod|region region|nmod|gene gene|compound|END_ENTITY	Evaluation of a short interspersed nucleotide element in the 3 ' untranslated region of the defective dystrophin gene of dogs with muscular_dystrophy .
3317278	0	nucleotide	35,45	elongation_factor_Tu	67,87	nucleotide	elongation factor Tu	CHEBI:36976	3168327(Tax:300852)	Chemical	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Sequence and identification of the nucleotide binding site for the elongation_factor_Tu from Thermus_thermophilus HB8 .
24505959	0	nucleotide	25,35	endothelial_nitric_oxide_synthase	53,86	nucleotide	endothelial nitric oxide synthase	CHEBI:36976	4846	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	-LSB- The influence of single nucleotide polymorphisms of endothelial_nitric_oxide_synthase and angiotensin-converting_enzyme on the course of pregnancy complicated by type 1 diabetes -RSB- .
20523082	0	nucleotide	16,26	engrailed_homeobox_2	44,64	nucleotide	engrailed homeobox 2	CHEBI:36976	2020	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Intronic single nucleotide polymorphisms of engrailed_homeobox_2 modulate the disease vulnerability of autism in a han chinese population .
2999520	0	nucleotide	76,86	env	103,106	nucleotide	env	CHEBI:36976	1491939(Tax:11908)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|gene gene|compound|END_ENTITY	Immunoglobulin G antibodies binding to a synthetic peptide deduced from the nucleotide sequence of the env gene of HTLV_I in patients with leukemia and rheumatoid_arthritis , HLA sensitized persons and blood donors .
3840930	0	nucleotide	4,14	env	31,34	nucleotide	env	CHEBI:36976	30816	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|gene gene|compound|END_ENTITY	The nucleotide sequence of the env gene from the human provirus ERV3 and isolation and characterization of an ERV3-specific cDNA .
6093363	0	nucleotide	4,14	env	31,34	nucleotide	env	CHEBI:36976	30816	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|gene gene|compound|END_ENTITY	The nucleotide sequence of the env gene and post-env region of bovine_leukemia_virus .
6246174	0	nucleotide	53,63	epidermal_growth_factor	15,38	nucleotide	epidermal growth factor	CHEBI:36976	397083(Tax:9823)	Chemical	Gene	system|compound|START_ENTITY END_ENTITY|nmod|system	The effects of epidermal_growth_factor on the cyclic nucleotide system in pig epidermis .
8798432	0	nucleotide	27,37	epidermal_growth_factor_receptor	58,90	nucleotide	epidermal growth factor receptor	CHEBI:36976	1956	Chemical	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Mutational analysis of the nucleotide binding site of the epidermal_growth_factor_receptor and v-Src protein-tyrosine kinases .
16150865	0	nucleotide	9,19	estrogen-related_receptor_alpha	26,57	nucleotide	estrogen-related receptor alpha	CHEBI:36976	2101	Chemical	Gene	START_ENTITY|nmod|site site|amod|END_ENTITY	A single nucleotide in an estrogen-related_receptor_alpha site can dictate mode of binding and peroxisome_proliferator-activated_receptor_gamma_coactivator_1alpha activation of target promoters .
12207901	0	nucleotide	7,17	estrogen_receptor_alpha	35,58	nucleotide	estrogen receptor alpha	CHEBI:36976	2099	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Single nucleotide polymorphisms of estrogen_receptor_alpha in human renal_cell_carcinoma .
15831512	0	nucleotide	27,37	estrogen_receptor_alpha	55,78	nucleotide	estrogen receptor alpha	CHEBI:36976	2099	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Association between single nucleotide polymorphisms of estrogen_receptor_alpha gene and efficacy of HRT on bone_mineral_density in post-menopausal Japanese women .
24772413	0	nucleotide	22,32	estrogen_receptor_alpha	50,73	nucleotide	estrogen receptor alpha	CHEBI:36976	2099	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Association of single nucleotide polymorphisms in estrogen_receptor_alpha gene with susceptibility to knee osteoarthritis : a case-control study in a Chinese Han population .
11705958	0	nucleotide	9,19	exfoliative_toxin_B	56,75	nucleotide	exfoliative toxin B	CHEBI:36976	17374496	Chemical	Gene	sequence|compound|START_ENTITY sequence|nmod|END_ENTITY	Complete nucleotide sequence of a Staphylococcus_aureus exfoliative_toxin_B plasmid and identification of a novel ADP-ribosyltransferase , EDIN-C .
11122097	0	nucleotide	7,17	factor_IX	39,48	nucleotide	factor IX	CHEBI:36976	2158	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Single nucleotide polymorphisms of the factor_IX gene for linkage analysis in the southern Chinese population .
22435631	0	nucleotide	7,17	fibroblast_growth_factor_4	55,81	nucleotide	fibroblast growth factor 4	CHEBI:36976	618474(Tax:9913)	Chemical	Gene	sequence|compound|START_ENTITY sequence|nmod|END_ENTITY	Common nucleotide sequence of structural gene encoding fibroblast_growth_factor_4 in eight cattle derived from three breeds .
18202316	0	nucleotide	20,30	filamin_A	43,52	nucleotide	filamin A	CHEBI:36976	192176(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|nmod|END_ENTITY	Binding of the P2Y2 nucleotide receptor to filamin_A regulates migration of vascular smooth muscle cells .
2846759	0	nucleotide	54,64	gH	81,83	nucleotide	gH	CHEBI:36976	1682472(Tax:10381)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|gene gene|compound|END_ENTITY	Conservation of glycoprotein_H -LRB- gH -RRB- in herpesviruses : nucleotide sequence of the gH gene from herpesvirus_saimiri .
21549340	0	nucleotide	113,123	gPAPP	137,142	nucleotide	gPAPP	CHEBI:36976	54928	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|appos|END_ENTITY	Chondrodysplasia and abnormal joint development associated with mutations in IMPAD1 , encoding the Golgi-resident nucleotide phosphatase , gPAPP .
14597182	0	nucleotide	25,35	gamma-glutamyl_hydrolase	63,87	nucleotide	gamma-glutamyl hydrolase	CHEBI:36976	8836	Chemical	Gene	Identification|nmod|START_ENTITY polymorphisms|nsubj|Identification polymorphisms|nmod|gene gene|amod|END_ENTITY	Identification of single nucleotide polymorphisms in the human gamma-glutamyl_hydrolase gene and characterization of promoter polymorphisms .
25644744	0	nucleotide	7,17	glucocorticoid_receptor	60,83	nucleotide	glucocorticoid receptor	CHEBI:36976	2908	Chemical	Gene	polymorphisms|nsubj|START_ENTITY polymorphisms|nmod|region region|nmod|gene gene|compound|END_ENTITY	Single nucleotide polymorphisms in non-coding region of the glucocorticoid_receptor gene and prednisone response in childhood acute_lymphoblastic_leukemia .
22710726	0	nucleotide	7,17	gonadotropin-releasing_hormone_receptor	60,99	nucleotide	gonadotropin-releasing hormone receptor	CHEBI:36976	2798	Chemical	Gene	polymorphisms|nsubj|START_ENTITY polymorphisms|nmod|region region|nmod|gene gene|amod|END_ENTITY	Single nucleotide polymorphisms in the regulatory region of gonadotropin-releasing_hormone_receptor gene and breast_cancer susceptibility .
4350846	0	nucleotide	103,113	growth_hormone_releasing_factor	22,53	nucleotide	growth hormone releasing factor	CHEBI:36976	2691	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of a purified growth_hormone_releasing_factor on growth_hormone secretion and pituitary cyclic nucleotide content .
6261501	0	nucleotide	61,71	growth_inhibitory_factor	22,46	nucleotide	growth inhibitory factor	CHEBI:36976	117038(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	Effect of a microbial growth_inhibitory_factor on the cyclic nucleotide metabolism of peritoneal macrophages .
26074017	0	nucleotide	27,37	hOGG1	62,67	nucleotide	hOGG1	D009711	4968	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Association between single nucleotide polymorphisms of MUTYH , hOGG1 and NEIL1 genes , and depression .
24318877	0	nucleotide	17,27	heat_shock_protein_70	48,69	nucleotide	heat shock protein 70	CHEBI:36976	3308	Chemical	Gene	factors|amod|START_ENTITY factors|nmod|END_ENTITY	Binding of human nucleotide exchange factors to heat_shock_protein_70 -LRB- Hsp70 -RRB- generates functionally distinct complexes in vitro .
15064106	0	nucleotide	28,38	hepatocyte_growth_factor	62,86	nucleotide	hepatocyte growth factor	CHEBI:36976	3082	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Identification of 21 single nucleotide polymorphisms in human hepatocyte_growth_factor gene and association with blood pressure and carotid_atherosclerosis in the Japanese population .
15551002	0	nucleotide	7,17	histamine_N-methyltransferase	50,79	nucleotide	histamine N-methyltransferase	CHEBI:36976	3176	Chemical	Gene	START_ENTITY|dobj|polymorphisms polymorphisms|nmod|END_ENTITY	Single nucleotide polymorphisms and haplotypes of histamine_N-methyltransferase in patients with gastric_ulcer .
8422436	0	nucleotide	55,65	histone_H1	44,54	nucleotide	histone H1	CHEBI:36976	24437(Tax:10116)	Chemical	Gene	site|compound|START_ENTITY site|amod|END_ENTITY	Specific non-enzymatic glycation of the rat histone_H1 nucleotide binding site in vitro in the presence of AlF4 - .
3931075	0	nucleotide	77,87	hsp70	106,111	nucleotide	hsp70	CHEBI:36976	3308	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Conserved features of eukaryotic hsp70 genes revealed by comparison with the nucleotide sequence of human hsp70 .
8463260	0	nucleotide	21,31	immunoglobulin-binding_protein	48,78	nucleotide	immunoglobulin-binding protein	CHEBI:36976	3309	Chemical	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Mutations within the nucleotide binding site of immunoglobulin-binding_protein inhibit ATPase activity and interfere with release of immunoglobulin heavy chain .
11511079	0	nucleotide	29,39	insulin	61,68	nucleotide	insulin	CHEBI:36976	3630	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Systematic search for single nucleotide polymorphisms in the insulin gene : evidence for a high frequency of -23 T -- > A in Japanese subjects .
17473382	0	nucleotide	24,34	insulin	4,11	nucleotide	insulin	CHEBI:36976	3630	Chemical	Gene	polymorphisms|amod|START_ENTITY single|dobj|polymorphisms single|nsubj|gene gene|compound|END_ENTITY	Two insulin gene single nucleotide polymorphisms associated with type 1 diabetes risk in the Finnish and Swedish populations .
24695378	0	nucleotide	22,32	insulin	67,74	nucleotide	insulin	CHEBI:36976	3630	Chemical	Gene	polymorphisms|compound|START_ENTITY associated|nsubjpass|polymorphisms associated|nmod|resistance resistance|compound|END_ENTITY	CDKAL1-related single nucleotide polymorphisms are associated with insulin resistance in a cross-sectional cohort of Greek children .
3292328	0	nucleotide	18,28	insulin	66,73	nucleotide	insulin	CHEBI:36976	3630	Chemical	Gene	substitution|amod|START_ENTITY Identification|nmod|substitution -LSB-|nsubj|Identification -LSB-|dobj|END_ENTITY	Identification of nucleotide substitution in gene encoding -LSB- LeuA3 -RSB- insulin in third Japanese family .
9628281	0	nucleotide	27,37	insulin	91,98	nucleotide	insulin	CHEBI:36976	3630	Chemical	Gene	polymorphism|amod|START_ENTITY polymorphism|nmod|region region|nmod|gene gene|compound|END_ENTITY	Identification of a single nucleotide insertion polymorphism in the upstream region of the insulin promoter factor-1 gene : an association study with diabetes_mellitus .
10791936	0	nucleotide	8,18	insulin-like_growth_factor_I	81,109	nucleotide	insulin-like growth factor I	CHEBI:36976	100034198(Tax:9796)	Chemical	Gene	structure|compound|START_ENTITY structure|nmod|END_ENTITY	Primary nucleotide structure of predominant and alternate splice forms of equine insulin-like_growth_factor_I and their gene expression patterns in tissues .
25802725	0	nucleotide	143,153	interleukin-6	175,188	nucleotide	interleukin-6	CHEBI:36976	3569	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|region region|amod|END_ENTITY	Response to the dipeptidyl_peptidase-4 inhibitors in Japanese patients with type 2 diabetes might be associated with a diplotype of two single nucleotide polymorphisms on the interleukin-6 promoter region under a certain level of physical activity .
3486405	0	nucleotide	9,19	interleukin_1_alpha	51,70	nucleotide	interleukin 1 alpha	CHEBI:36976	3552	Chemical	Gene	sequence|compound|START_ENTITY sequence|nmod|END_ENTITY	Complete nucleotide sequence of the gene for human interleukin_1_alpha .
26831416	0	nucleotide	49,59	interleukin_4	77,90	nucleotide	interleukin 4	D009711	3565	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	A preliminary study on the association of single nucleotide polymorphisms of interleukin_4 -LRB- IL4 -RRB- , IL13 , IL4 receptor alpha -LRB- IL4Ra -RRB- _ Toll-like_receptor_4 -LRB- TLR4 -RRB- genes with asthma in Indian adults .
11920956	0	nucleotide	25,35	kallikrein_10	63,76	nucleotide	kallikrein 10	CHEBI:36976	5655	Chemical	Gene	Identification|nmod|START_ENTITY polymorphisms|nsubj|Identification polymorphisms|nmod|gene gene|amod|END_ENTITY	Identification of single nucleotide polymorphisms in the human kallikrein_10 -LRB- KLK10 -RRB- gene and their association with prostate , breast , testicular , and ovarian_cancers .
15638863	0	nucleotide	22,32	klotho	50,56	nucleotide	klotho	CHEBI:36976	9365	Chemical	Gene	Association|nmod|START_ENTITY polymorphisms|nsubj|Association polymorphisms|nmod|END_ENTITY	Association of single nucleotide polymorphisms in klotho with priapism in sickle cell anaemia .
2120234	0	nucleotide	49,59	lacR	72,76	nucleotide	lacR	CHEBI:36976	12471540	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Molecular cloning , transcriptional analysis , and nucleotide sequence of lacR , a gene encoding the repressor of the lactose phosphotransferase system of Lactococcus_lactis .
15564891	0	nucleotide	7,17	leptin_receptor	39,54	nucleotide	leptin receptor	CHEBI:36976	3953	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Single nucleotide polymorphisms in the leptin_receptor gene : studies in anorexia_nervosa .
8294021	0	nucleotide	37,47	leu-1	4,9	nucleotide	leu-1	CHEBI:36976	852875(Tax:4932)	Chemical	Gene	gene|dep|START_ENTITY gene|amod|END_ENTITY	The leu-1 gene of Neurospora_crassa : nucleotide and deduced amino_acid sequence comparisons .
11641914	0	nucleotide	119,129	low-density_lipoprotein_receptor	151,183	nucleotide	low-density lipoprotein receptor	CHEBI:36976	3949	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	-LSB- Identification of novel missense mutation G571E , novel silent mutation H229H , nonsense mutation C74X , and four single nucleotide polymorphisms in the low-density_lipoprotein_receptor in patients with familial_hypercholesterolemia from St. Petersburg -RSB- .
7789514	0	nucleotide	4,14	ltf	48,51	nucleotide	ltf	CHEBI:36976	2777639(Tax:10726)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|gene gene|compound|END_ENTITY	The nucleotide sequence of the bacteriophage_T5 ltf gene .
11712863	0	nucleotide	7,17	mannose-binding_lectin	39,61	nucleotide	mannose-binding lectin	CHEBI:36976	4153	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Single nucleotide polymorphisms of the mannose-binding_lectin are associated with susceptibility to primary_biliary_cirrhosis .
21853476	0	nucleotide	7,17	matrix_metallopeptidase_3	35,60	nucleotide	matrix metallopeptidase 3	CHEBI:36976	4314	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Single nucleotide polymorphisms of matrix_metallopeptidase_3 and risk of gliomas in a Chinese Han population .
19932942	0	nucleotide	79,89	melanocortin-1_receptor	111,134	nucleotide	melanocortin-1 receptor	CHEBI:36976	4157	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Unexpectedly severe acute radiotherapy side effects are associated with single nucleotide polymorphisms of the melanocortin-1_receptor .
12133463	0	nucleotide	8,18	methylenetetrahydrofolate_reductase	36,71	nucleotide	methylenetetrahydrofolate reductase	CHEBI:36976	4524	Chemical	Gene	START_ENTITY|nmod|gene gene|amod|END_ENTITY	-LSB- Single nucleotide polymorphisms in methylenetetrahydrofolate_reductase gene and susceptibility to cancer_of_the_gastric_cardia in Chinese population -RSB- .
152644	0	nucleotide	15,25	mitochondrial_ATPase	70,90	nucleotide	mitochondrial ATPase	CHEBI:36976	514	Chemical	Gene	reactions|amod|START_ENTITY Specificity|nmod|reactions Specificity|acl|utilising utilising|dobj|END_ENTITY	Specificity of nucleotide binding and coupled reactions utilising the mitochondrial_ATPase .
8484802	0	nucleotide	47,57	mitochondrial_aldehyde_dehydrogenase	74,110	nucleotide	mitochondrial aldehyde dehydrogenase	CHEBI:36976	29539(Tax:10116)	Chemical	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Derivatives of cinnamic_acid interact with the nucleotide binding site of mitochondrial_aldehyde_dehydrogenase .
19506371	0	nucleotide	7,17	monocyte_chemoattractant_protein-1	35,69	nucleotide	monocyte chemoattractant protein-1	CHEBI:36976	6347	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Single nucleotide polymorphisms in monocyte_chemoattractant_protein-1 and its receptor act synergistically to increase the risk of carotid_atherosclerosis .
3354207	0	nucleotide	9,19	mu_1	115,119	nucleotide	mu 1	CHEBI:36976	2944	Chemical	Gene	sequence|compound|START_ENTITY sequence|nmod|END_ENTITY	Complete nucleotide sequence of the M2 gene segment of reovirus_type_3 dearing and analysis of its protein product mu_1 .
11054767	0	nucleotide	20,30	mu_opioid_receptor	58,76	nucleotide	mu opioid receptor	CHEBI:36976	4988	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Detection of single nucleotide polymorphisms of the human mu_opioid_receptor gene by hybridization or single nucleotide extension on custom oligonucleotide gelpad microchips : potential in studies of addiction .
11457836	0	nucleotide	7,17	mu_opioid_receptor	45,63	nucleotide	mu opioid receptor	CHEBI:36976	4988	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Single nucleotide polymorphisms in the human mu_opioid_receptor gene alter basal G protein coupling and calmodulin binding .
12783859	0	nucleotide	25,35	multidrug_resistance-associated_protein	54,93	nucleotide	multidrug resistance-associated protein	CHEBI:36976	8714	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	ATP binding to the first nucleotide binding domain of multidrug_resistance-associated_protein plays a regulatory role at low nucleotide concentration , whereas ATP hydrolysis at the second plays a dominant role in ATP-dependent leukotriene C4 transport .
12406647	0	nucleotide	7,17	multidrug_resistance_associated_protein_2	35,76	nucleotide	multidrug resistance associated protein 2	CHEBI:36976	1244	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Single nucleotide polymorphisms in multidrug_resistance_associated_protein_2 -LRB- MRP2/ABCC2 -RRB- : its impact on drug disposition .
25087925	0	nucleotide	7,17	multidrug_resistance_gene_1	35,62	nucleotide	multidrug resistance gene 1	CHEBI:36976	5243	Chemical	Gene	START_ENTITY|dobj|polymorphisms polymorphisms|nmod|END_ENTITY	Single nucleotide polymorphisms of multidrug_resistance_gene_1 -LRB- MDR1 -RRB- and risk of chronic_myeloid_leukemia .
8268211	0	nucleotide	66,76	muscle_creatine_kinase	94,116	nucleotide	muscle creatine kinase	CHEBI:36976	100009056(Tax:9986)	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Evidence for proximal cysteine and lysine residues present at the nucleotide domain of rabbit muscle_creatine_kinase .
11971905	0	nucleotide	12,22	myosin	48,54	nucleotide	myosin	CHEBI:36976	79784	Chemical	Gene	motor|amod|START_ENTITY motor|amod|binding binding|nmod|II II|compound|END_ENTITY	Analysis of nucleotide binding to Dictyostelium myosin II motor domains containing a single tryptophan near the active site .
127886	0	nucleotide	109,119	myosin	67,73	nucleotide	myosin	CHEBI:36976	79784	Chemical	Gene	presence|nmod|START_ENTITY subfragment-one|nmod|presence subfragment-one|nsubj|depolarization depolarization|nmod|END_ENTITY	Time-dependent fluorescence depolarization and lifetime studies of myosin subfragment-one in the presence of nucleotide and actin .
144522	0	nucleotide	10,20	myosin	84,90	nucleotide	myosin	CHEBI:36976	79784	Chemical	Gene	groups|amod|START_ENTITY Effect|nmod|groups Effect|nmod|END_ENTITY	Effect of nucleotide binding on the proximity of the essential sulfhydryl groups of myosin .
14502270	0	nucleotide	37,47	myosin	59,65	nucleotide	myosin	CHEBI:36976	79784	Chemical	Gene	model|nmod|START_ENTITY release|nsubj|model release|nmod|END_ENTITY	A structural model for actin-induced nucleotide release in myosin .
14508495	0	nucleotide	78,88	myosin	53,59	nucleotide	myosin	CHEBI:36976	79784	Chemical	Gene	releases|xcomp|START_ENTITY releases|nsubj|binding binding|nmod|END_ENTITY	Electron cryo-microscopy shows how strong binding of myosin to actin releases nucleotide .
17028139	0	nucleotide	16,26	myosin	37,43	nucleotide	myosin	CHEBI:36976	79784	Chemical	Gene	pocket|amod|START_ENTITY pocket|nmod|END_ENTITY	Dynamics of the nucleotide pocket of myosin measured by spin-labeled nucleotides .
185204	0	nucleotide	30,40	myosin	58,64	nucleotide	myosin	CHEBI:36976	79784	Chemical	Gene	sites|amod|START_ENTITY sites|nmod|END_ENTITY	Interactions of the actin and nucleotide binding sites on myosin subfragment 1 .
19804726	0	nucleotide	35,45	myosin	56,62	nucleotide	myosin	CHEBI:36976	79784	Chemical	Gene	base|amod|START_ENTITY base|nmod|END_ENTITY	Analysis of the interaction of the nucleotide base with myosin and the effect on substrate efficacy .
2148937	0	nucleotide	121,131	myosin	35,41	nucleotide	myosin	CHEBI:36976	79784	Chemical	Gene	site|amod|START_ENTITY phosphate|nmod|site influence|nmod|phosphate Interaction|dep|influence Interaction|nmod|F-actin-AMPPNP F-actin-AMPPNP|nmod|END_ENTITY	Interaction of F-actin-AMPPNP with myosin subfragment-1 and troponin-tropomyosin : influence of an extra phosphate at the nucleotide binding site in F-actin on its function .
23121488	0	nucleotide	7,17	myosin	38,44	nucleotide	myosin	CHEBI:36976	79784	Chemical	Gene	coordination|amod|START_ENTITY coordination|nmod|site site|amod|END_ENTITY	Mn -LRB- 2 + -RRB- - nucleotide coordination at the myosin active site as detected by pulsed electron paramagnetic resonance .
2713347	0	nucleotide	10,20	myosin	42,48	nucleotide	myosin	CHEBI:36976	79784	Chemical	Gene	structure|amod|START_ENTITY structure|nmod|END_ENTITY	Effect of nucleotide structure on cardiac myosin subfragment 1 transient kinetics .
2738037	0	nucleotide	104,114	myosin	28,34	nucleotide	myosin	CHEBI:36976	79784	Chemical	Gene	absence|nmod|START_ENTITY binding|nmod|absence Interaction|dep|binding Interaction|nmod|heads heads|nmod|END_ENTITY	Interaction of two heads of myosin with F-actin : binding of H-meromyosin with F-actin in the absence of nucleotide .
3904736	0	nucleotide	28,38	myosin	78,84	nucleotide	myosin	CHEBI:36976	79784	Chemical	Gene	+|amod|START_ENTITY studies|nmod|+ studies|dep|domains domains|nmod|END_ENTITY	Fluorescence studies on the nucleotide - and Ca2 + - binding domains of molluscan myosin .
5960869	0	nucleotide	26,36	myosin	68,74	nucleotide	myosin	CHEBI:36976	79784	Chemical	Gene	Exchange|nmod|START_ENTITY Exchange|nmod|presence presence|nmod|END_ENTITY	Exchange of F-actin-bound nucleotide in the presence and absence of myosin .
7142190	0	nucleotide	14,24	myosin	43,49	nucleotide	myosin	CHEBI:36976	79784	Chemical	Gene	START_ENTITY|nmod|the the|nmod|END_ENTITY	The effect of nucleotide on the binding of myosin subfragment 1 to regulated actin .
7503740	0	nucleotide	11,21	myosin	41,47	nucleotide	myosin	CHEBI:36976	79784	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of nucleotide on skeletal muscle myosin unfolding in myofibrils by DSC .
7787065	0	nucleotide	29,39	myosin	22,28	nucleotide	myosin	CHEBI:36976	396465(Tax:9031)	Chemical	Gene	complexes|amod|START_ENTITY studies|dep|complexes studies|nmod|END_ENTITY	Structural studies of myosin : nucleotide complexes : a revised model for the molecular basis of muscle_contraction .
8180239	0	nucleotide	103,113	myosin	42,48	nucleotide	myosin	CHEBI:36976	79784	Chemical	Gene	substitution|nmod|START_ENTITY influenced|nmod|substitution influenced|csubjpass|sliding sliding|nmod|END_ENTITY	In vitro ATP-dependent F-actin sliding on myosin is not influenced by substitution or removal of bound nucleotide .
8274637	0	nucleotide	91,101	myosin	52,58	nucleotide	myosin	CHEBI:36976	79784	Chemical	Gene	absence|nmod|START_ENTITY kinetics|nmod|absence kinetics|nmod|subfragment-1 subfragment-1|compound|END_ENTITY	Transient kinetics of the interaction of actin with myosin subfragment-1 in the absence of nucleotide .
8298019	0	nucleotide	87,97	myosin	29,35	nucleotide	myosin	CHEBI:36976	79784	Chemical	Gene	meromyosin|nmod|START_ENTITY meromyosin|nsubj|compressibility compressibility|nmod|END_ENTITY	Adiabatic compressibility of myosin subfragment-1 and heavy meromyosin with or without nucleotide .
8388733	0	nucleotide	40,50	myosin	4,10	nucleotide	myosin	CHEBI:36976	79784	Chemical	Gene	response|acl|START_ENTITY molecule|dep|response molecule|compound|END_ENTITY	The myosin molecule -- charge response to nucleotide binding .
8603721	0	nucleotide	15,25	myosin	68,74	nucleotide	myosin	CHEBI:36976	79784	Chemical	Gene	exchange|amod|START_ENTITY Measurement|nmod|exchange kinetics|nsubj|Measurement kinetics|nmod|filaments filaments|compound|END_ENTITY	Measurement of nucleotide exchange kinetics with isolated synthetic myosin filaments using flash photolysis .
9497352	0	nucleotide	61,71	myosin	18,24	nucleotide	myosin	CHEBI:36976	79784	Chemical	Gene	pocket|compound|START_ENTITY adjacent|nmod|pocket loop|amod|adjacent Kinetic|nmod|loop Kinetic|nmod|END_ENTITY	Kinetic tuning of myosin via a flexible loop adjacent to the nucleotide binding pocket .
9889853	0	nucleotide	27,37	myosin	69,75	nucleotide	myosin	CHEBI:36976	79784	Chemical	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Communications between the nucleotide - and actin-binding site of the myosin head in muscle fibers .
21640122	0	nucleotide	50,60	myosin_V	71,79	nucleotide	myosin V	CHEBI:36976	4644	Chemical	Gene	pocket|amod|START_ENTITY pocket|nmod|END_ENTITY	EPR spectra and molecular dynamics agree that the nucleotide pocket of myosin_V is closed and that it opens on binding actin .
20536908	0	nucleotide	7,17	myostatin	39,48	nucleotide	myostatin	CHEBI:36976	2660	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Single nucleotide polymorphisms in the myostatin -LRB- MSTN -RRB- and muscle creatine_kinase -LRB- CKM -RRB- genes are not associated with elite endurance performance .
24368331	0	nucleotide	7,17	myostatin	35,44	nucleotide	myostatin	CHEBI:36976	100033832(Tax:9796)	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Single nucleotide polymorphisms of myostatin gene in Chinese domestic_horses .
8400137	0	nucleotide	13,23	ndhF	27,31	nucleotide	ndhF	CHEBI:36976	800484(Tax:4097)	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Ninety extra nucleotide in ndhF gene of tobacco chloroplast DNA : a summary of revisions to the 1986 genome sequence .
7877490	0	nucleotide	61,71	nifK	84,88	nucleotide	nifK	CHEBI:36976	84365	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Assessing horizontal transfer of nifHDK genes in eubacteria : nucleotide sequence of nifK from Frankia strain HFPCcI3 .
15894713	0	nucleotide	7,17	norepinephrine_transporter	45,71	nucleotide	norepinephrine transporter	CHEBI:36976	6530	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Single nucleotide polymorphisms in the human norepinephrine_transporter gene affect expression , trafficking , antidepressant interaction , and protein kinase C regulation .
15226675	0	nucleotide	66,76	organic_anion_transporting_polypeptide-C	109,149	nucleotide	organic anion transporting polypeptide-C	CHEBI:36976	10599	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic_anion_transporting_polypeptide-C -LRB- OATP-C , SLCO1B1 -RRB- .
21934640	0	nucleotide	38,48	oxytocin_receptor	70,87	nucleotide	oxytocin receptor	CHEBI:36976	5021	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Test of association between 10 single nucleotide polymorphisms in the oxytocin_receptor gene and conduct_disorder .
10397753	0	nucleotide	38,48	p21	25,28	nucleotide	p21	CHEBI:36976	1026	Chemical	Gene	repair|amod|START_ENTITY inhibits|xcomp|repair inhibits|nsubj|domain domain|nmod|END_ENTITY	The C-terminal domain of p21 inhibits nucleotide excision repair In vitro and In vivo .
18788572	0	nucleotide	8,18	p21	57,60	nucleotide	p21	CHEBI:36976	644914	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	-LSB- Single nucleotide polymorphisms in cell cycle regulator p21 and p27 genes are associated with susceptibility to epithelial_ovarian_cancer -RSB- .
20126416	0	nucleotide	25,35	p21	57,60	nucleotide	p21	CHEBI:36976	1026	Chemical	Gene	Identification|nmod|START_ENTITY polymorphisms|nsubj|Identification polymorphisms|nmod|gene gene|amod|END_ENTITY	Identification of single nucleotide polymorphisms in the p21 -LRB- CDKN1A -RRB- gene and correlations with longevity in the Italian population .
2108052	0	nucleotide	26,36	p21	53,56	nucleotide	p21	CHEBI:36976	644914	Chemical	Gene	exchange|amod|START_ENTITY effects|nmod|exchange studied|nsubj|effects studied|advmod|as as|nmod:npmod|proteins proteins|nummod|END_ENTITY	Conformational effects of nucleotide exchange in ras p21 proteins as studied by fluorescence spectroscopy .
2191717	0	nucleotide	51,61	p21	124,127	nucleotide	p21	CHEBI:36976	644914	Chemical	Gene	proteins|compound|START_ENTITY loop|nmod|proteins study|nmod|loop study|dep|evidence evidence|nmod|bonding bonding|nmod|END_ENTITY	NMR study of the phosphoryl binding loop in purine nucleotide proteins : evidence for strong hydrogen bonding in human N-ras p21 .
22320961	0	nucleotide	7,17	p21	39,42	nucleotide	p21	CHEBI:36976	644914	Chemical	Gene	START_ENTITY|dobj|polymorphisms polymorphisms|nmod|END_ENTITY	Single nucleotide polymorphisms in the p21 and bcl2 cancer susceptibility genes and breast_cancer risk in Saudi Arabia .
6438627	0	nucleotide	10,20	p21	63,66	nucleotide	p21	CHEBI:36976	644914	Chemical	Gene	START_ENTITY|xcomp|binding binding|nmod|protein protein|amod|END_ENTITY	Guanosine nucleotide binding by highly purified Ha-ras-encoded p21 protein produced in Escherichia_coli .
6609772	0	nucleotide	87,97	p21	120,123	nucleotide	p21	CHEBI:36976	644914	Chemical	Gene	properties|amod|START_ENTITY properties|nmod|END_ENTITY	Activation of ras genes in human tumors does not affect localization , modification , or nucleotide binding properties of p21 .
7665622	0	nucleotide	14,24	p21	82,85	nucleotide	p21	CHEBI:36976	1026	Chemical	Gene	excision|amod|START_ENTITY Inhibition|nmod|excision repair|nsubj|Inhibition repair|nmod|END_ENTITY	Inhibition of nucleotide excision repair by the cyclin-dependent kinase inhibitor p21 .
7730301	0	nucleotide	10,20	p21	43,46	nucleotide	p21	CHEBI:36976	644914	Chemical	Gene	specificity|amod|START_ENTITY specificity|nmod|Ha-Ras Ha-Ras|nummod|END_ENTITY	Switching nucleotide specificity of Ha-Ras p21 by a single amino_acid substitution at aspartate 119 .
9312123	1	nucleotide	114,124	p21	163,166	nucleotide	p21	CHEBI:36976	644914	Chemical	Gene	exchange|amod|START_ENTITY factor-stimulated|dobj|exchange factor-stimulated|nmod|form form|nmod|Ha-ras Ha-ras|nummod|END_ENTITY	Prevention of the guanine_nucleotide exchange factor-stimulated nucleotide exchange on the active form of Ha-ras p21 .
2116014	0	nucleotide	20,30	p21ras	63,69	nucleotide	p21ras	CHEBI:36976	3265	Chemical	Gene	activity|amod|START_ENTITY Identification|nmod|activity Identification|nmod|END_ENTITY	Identification of a nucleotide exchange-promoting activity for p21ras .
10426782	0	nucleotide	27,37	p53	20,23	nucleotide	p53	CHEBI:36976	7157	Chemical	Gene	repair|amod|START_ENTITY roles|nmod|repair roles|nmod|END_ENTITY	Potential roles for p53 in nucleotide excision repair .
10611334	0	nucleotide	92,102	p53	28,31	nucleotide	p53	CHEBI:36976	7157	Chemical	Gene	repair|compound|START_ENTITY compromised|dobj|repair compromised|nmod|exhibit exhibit|compound|END_ENTITY	Human cells compromised for p53 function exhibit defective global and transcription-coupled nucleotide excision repair , whereas cells compromised for pRb function are defective only in global repair .
10634308	0	nucleotide	34,44	p53	10,13	nucleotide	p53	CHEBI:36976	7157	Chemical	Gene	repair|amod|START_ENTITY suppressor|nmod|repair suppressor|compound|END_ENTITY	Effect of p53 tumor suppressor on nucleotide excision repair in human colon_carcinoma cells treated with 4-nitroquinoline_1-oxide .
11205244	0	nucleotide	35,45	p53	115,118	nucleotide	p53	CHEBI:36976	22060(Tax:10090)	Chemical	Gene	synthesis|amod|START_ENTITY inhibitors|nmod|synthesis induced|nmod|inhibitors induced|nmod|cells cells|acl:relcl|lack lack|dobj|expression expression|compound|END_ENTITY	Apoptosis induced by inhibitors of nucleotide synthesis in deoxyadenosine-resistant leukemia L1210 cells that lack p53 expression .
11323179	0	nucleotide	12,22	p53	51,54	nucleotide	p53	CHEBI:36976	22060(Tax:10090)	Chemical	Gene	repair|amod|START_ENTITY role|nmod|repair role|nmod|END_ENTITY	The role of nucleotide excision repair and loss of p53 in mutagenesis and carcinogenesis .
12170774	0	nucleotide	2,12	p53	44,47	nucleotide	p53	CHEBI:36976	7157	Chemical	Gene	master-switch|amod|START_ENTITY master-switch|dep|END_ENTITY	A nucleotide excision repair master-switch : p53 regulated coordinate induction of global genomic repair genes .
12234998	0	nucleotide	20,30	p53	0,3	nucleotide	p53	CHEBI:36976	7157	Chemical	Gene	repair|amod|START_ENTITY controls|dobj|repair controls|nsubj|END_ENTITY	p53 controls global nucleotide excision repair of low levels of structurally diverse benzo -LRB- g -RRB- chrysene-DNA adducts in human fibroblasts .
12574133	0	nucleotide	44,54	p53	0,3	nucleotide	p53	CHEBI:36976	7157	Chemical	Gene	repair|amod|START_ENTITY factor|nmod|repair factor|nsubj|END_ENTITY	p53 is a chromatin accessibility factor for nucleotide excision repair of DNA damage .
12713809	0	nucleotide	46,56	p53	17,20	nucleotide	p53	CHEBI:36976	7157	Chemical	Gene	XPC|amod|START_ENTITY recruitment|nmod|XPC recruitment|compound|END_ENTITY	Tumor suppressor p53 dependent recruitment of nucleotide excision repair factors XPC and TFIIH to DNA damage .
12771027	0	nucleotide	15,25	p53	0,3	nucleotide	p53	CHEBI:36976	7157	Chemical	Gene	excision|amod|START_ENTITY excision|nummod|END_ENTITY	p53 responsive nucleotide excision repair gene products p48 and XPC , but not p53 , localize to sites of UV-irradiation-induced DNA damage , in vivo .
12826282	0	nucleotide	9,19	p53	87,90	nucleotide	p53	CHEBI:36976	7157	Chemical	Gene	excision|compound|START_ENTITY repair|nsubj|excision repair|ccomp|enhances enhances|dobj|repair repair|nmod|fibroblasts fibroblasts|nummod|END_ENTITY	The DDB2 nucleotide excision repair gene product p48 enhances global genomic repair in p53 deficient human fibroblasts .
12967652	0	nucleotide	52,62	p53	0,3	nucleotide	p53	CHEBI:36976	7157	Chemical	Gene	excision|amod|START_ENTITY recognition|nmod|excision END_ENTITY|nmod|recognition	p53 and regulation of DNA damage recognition during nucleotide excision repair .
15665582	0	nucleotide	47,57	p53	23,26	nucleotide	p53	CHEBI:36976	7157	Chemical	Gene	repair|amod|START_ENTITY roles|nmod|repair roles|nmod|suppressor suppressor|compound|END_ENTITY	The potential roles of p53 tumor suppressor in nucleotide excision repair -LRB- NER -RRB- and base excision repair -LRB- BER -RRB- .
15939931	0	nucleotide	92,102	p53	121,124	nucleotide	p53	CHEBI:36976	7157	Chemical	Gene	variations|compound|START_ENTITY variations|nmod|gene gene|compound|END_ENTITY	DNA microarrays on a dendron-modified surface improve significantly the detection of single nucleotide variations in the p53 gene .
16357521	0	nucleotide	64,74	p53	92,95	nucleotide	p53	CHEBI:36976	7157	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	ENU administration causes genomic instability along with single nucleotide polymorphisms in p53 during gliomagenesis : T11TS administration demonstrated in vivo apoptosis of these genetically altered tumor cells .
1656362	0	nucleotide	82,92	p53	4,7	nucleotide	p53	CHEBI:36976	7157	Chemical	Gene	pattern|amod|START_ENTITY mutated|nmod|pattern mutated|nsubjpass|gene gene|compound|END_ENTITY	The p53 gene is very frequently mutated in small-cell_lung_cancer with a distinct nucleotide substitution pattern .
17186536	0	nucleotide	18,28	p53	73,76	nucleotide	p53	CHEBI:36976	7157	Chemical	Gene	polymorphisms|nsubj|START_ENTITY polymorphisms|nmod|region region|nmod|gene gene|compound|END_ENTITY	Four novel single nucleotide polymorphisms within the promoter region of p53 gene and their associations with uterine_leiomyoma .
1761576	0	nucleotide	8,18	p53	61,64	nucleotide	p53	CHEBI:36976	22060(Tax:10090)	Chemical	Gene	biosynthesis|compound|START_ENTITY regulated|nsubjpass|biosynthesis regulated|nmod|concentration concentration|compound|END_ENTITY	Guanine nucleotide biosynthesis is regulated by the cellular p53 concentration .
18003626	0	nucleotide	86,96	p53	12,15	nucleotide	p53	CHEBI:36976	7157	Chemical	Gene	repair|amod|START_ENTITY regulate|dobj|repair ability|acl|regulate overrides|dobj|ability overrides|nsubj|role role|nmod|END_ENTITY	The role of p53 in DNA damage-mediated cytotoxicity overrides its ability to regulate nucleotide excision repair in human fibroblasts .
18343205	0	nucleotide	50,60	p53	43,46	nucleotide	p53	CHEBI:36976	7157	Chemical	Gene	excision|amod|START_ENTITY END_ENTITY|nmod|excision	Direct involvement of the tumor suppressor p53 in nucleotide excision repair .
18434539	0	nucleotide	30,40	p53	106,109	nucleotide	p53	CHEBI:36976	7157	Chemical	Gene	pools|compound|START_ENTITY synthesis|nmod|pools causes|nsubj|synthesis causes|dobj|damage damage|acl:relcl|triggers triggers|dobj|activation activation|compound|END_ENTITY	DNA synthesis from unbalanced nucleotide pools causes limited DNA damage that triggers ATR-CHK1-dependent p53 activation .
18440285	0	nucleotide	41,51	p53	24,27	nucleotide	p53	CHEBI:36976	7157	Chemical	Gene	START_ENTITY|nsubj|activation activation|nmod|END_ENTITY	Sustained activation of p53 in confluent nucleotide excision repair-deficient cells resistant to ultraviolet-induced apoptosis .
22414890	0	nucleotide	27,37	p53	55,58	nucleotide	p53	CHEBI:36976	100062044(Tax:9796)	Chemical	Gene	Association|nmod|START_ENTITY polymorphisms|nsubj|Association polymorphisms|nmod|END_ENTITY	Association between single nucleotide polymorphisms in p53 and abortion in Thoroughbred mares .
24173110	0	nucleotide	27,37	p53	59,62	nucleotide	p53	CHEBI:36976	7157	Chemical	Gene	Association|nmod|START_ENTITY polymorphisms|nsubj|Association polymorphisms|nmod|pathway pathway|compound|END_ENTITY	Association between single nucleotide polymorphisms in the p53 pathway and response to radiotherapy in patients with nasopharyngeal_carcinoma .
24507714	0	nucleotide	21,31	p53	61,64	nucleotide	p53	CHEBI:36976	7157	Chemical	Gene	enzyme|amod|START_ENTITY controls|nsubj|enzyme controls|dobj|activation activation|compound|END_ENTITY	Back to bases : how a nucleotide biosynthetic enzyme controls p53 activation .
26067754	0	nucleotide	14,24	p53	46,49	nucleotide	p53	D009711	7157	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|nmod|END_ENTITY	Regulation of nucleotide metabolism by mutant p53 contributes to its gain-of-function activities .
8134127	0	nucleotide	43,53	p53	70,73	nucleotide	p53	CHEBI:36976	7157	Chemical	Gene	affecting|dobj|START_ENTITY affecting|nmod|257 257|nmod|gene gene|compound|END_ENTITY	Two germ-line mutations affecting the same nucleotide at codon 257 of p53 gene , a rare site for mutations .
8333854	0	nucleotide	60,70	p53	6,9	nucleotide	p53	CHEBI:36976	301300(Tax:10116)	Chemical	Gene	biosynthesis|amod|START_ENTITY effects|nmod|biosynthesis salvage|nsubj|effects causes|ccomp|salvage causes|nsubj|END_ENTITY	Human p53 , mutated at codon 273 , causes distinct effects on nucleotide biosynthesis salvage pathway key enzymes in Rat-1 cells and in their derivatives expressing activated ras oncogene .
8590759	0	nucleotide	27,37	p53	20,23	nucleotide	p53	CHEBI:36976	7157	Chemical	Gene	activity|amod|START_ENTITY END_ENTITY|nmod|activity	-LSB- Opposite effect of p53 on nucleotide metabolizing enzyme activity in Rat1 cells and their sublines , transformed by N-RAS or v-mos oncogenes -RSB- .
9095000	0	nucleotide	44,54	p53	26,29	nucleotide	p53	CHEBI:36976	22060(Tax:10090)	Chemical	Gene	excision|amod|START_ENTITY regulation|nmod|excision regulation|compound|END_ENTITY	Differentiation-dependent p53 regulation of nucleotide excision repair in keratinocytes .
9346961	0	nucleotide	69,79	p53	24,27	nucleotide	p53	CHEBI:36976	7157	Chemical	Gene	repair|compound|START_ENTITY required|nmod|repair required|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of wild-type p53 is required for efficient global genomic nucleotide excision repair in UV-irradiated human fibroblasts .
9628350	0	nucleotide	138,148	p53	26,29	nucleotide	p53	CHEBI:36976	7157	Chemical	Gene	deletions|amod|START_ENTITY processes|nmod|deletions arise|nmod|processes arise|nsubj|mutations mutations|nmod|END_ENTITY	Accumulating mutations of p53 in colon_tumor and hairy_cell_leukemia do not arise from methylation/deamination processes , but rather from nucleotide deletions and insertions .
8409921	0	nucleotide	9,19	pabB	93,97	nucleotide	pabB	CHEBI:36976	12393289	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Cloning , nucleotide sequence and expression in Streptomyces_lividans and Escherichia_coli of pabB from Lactococcus_lactis_subsp .
6086460	0	nucleotide	23,33	parathyroid_hormone	66,85	nucleotide	parathyroid hormone	CHEBI:36976	280903(Tax:9913)	Chemical	Gene	sequence|compound|START_ENTITY sequence|nmod|END_ENTITY	Isolation and complete nucleotide sequence of the gene for bovine parathyroid_hormone .
2342478	0	nucleotide	48,58	parathyroid_hormone-like_peptide	14,46	nucleotide	parathyroid hormone-like peptide	CHEBI:36976	24695(Tax:10116)	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|dep|sequence	Gene-encoding parathyroid_hormone-like_peptide : nucleotide sequence of the rat gene and comparison with the human homologue .
2322274	0	nucleotide	8,18	parvalbumin	35,46	nucleotide	parvalbumin	CHEBI:36976	396531(Tax:9031)	Chemical	Gene	START_ENTITY|dobj|sequence sequence|nmod|END_ENTITY	Partial nucleotide sequence of the parvalbumin from chicken thymus designated `` avian thymic hormone '' .
12390022	0	nucleotide	31,41	phenol_sulfotransferase	57,80	nucleotide	phenol sulfotransferase	CHEBI:36976	6817	Chemical	Gene	specificity|amod|START_ENTITY specificity|nmod|END_ENTITY	A single mutation converts the nucleotide specificity of phenol_sulfotransferase from PAP to AMP .
15530708	0	nucleotide	7,17	phosphodiesterase-4	18,37	nucleotide	phosphodiesterase-4	CHEBI:36976	5141	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Cyclic nucleotide phosphodiesterase-4 inhibitors : a promising therapeutic approach to premature_birth ?
19231363	0	nucleotide	26,36	phosphodiesterase_4	37,56	nucleotide	phosphodiesterase 4	CHEBI:36976	5141	Chemical	Gene	activities|amod|START_ENTITY activities|amod|END_ENTITY	The measurement of cyclic nucleotide phosphodiesterase_4 activities via the quantification of inorganic phosphate with malachite green .
17097801	0	nucleotide	77,87	phosphodiesterase_type_4	88,112	nucleotide	phosphodiesterase type 4	CHEBI:36976	5141	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|amod|END_ENTITY	Relaxation of phasic contractile activity of human detrusor strips by cyclic nucleotide phosphodiesterase_type_4 inhibition .
3541923	0	nucleotide	8,18	phospholipase_C	33,48	nucleotide	phospholipase C	CHEBI:36976	100009319(Tax:9986)	Chemical	Gene	START_ENTITY|dobj|regulation regulation|nmod|activity activity|amod|END_ENTITY	Guanine nucleotide regulation of phospholipase_C activity in permeabilized rabbit neutrophils .
8223581	0	nucleotide	104,114	plasma_cell_membrane_glycoprotein_PC-1	61,99	nucleotide	plasma cell membrane glycoprotein PC-1	CHEBI:36976	18605(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification and characterization of a soluble form of the plasma_cell_membrane_glycoprotein_PC-1 -LRB- 5 ' - nucleotide phosphodiesterase -RRB- .
15943782	0	nucleotide	7,17	prion_protein	39,52	nucleotide	prion protein	CHEBI:36976	494014(Tax:9823)	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Single nucleotide polymorphisms of the prion_protein gene -LRB- PRNP -RRB- in Chinese pig breeds .
7492700	0	nucleotide	32,42	prorelaxin	21,31	nucleotide	prorelaxin	CHEBI:36976	101831439	Chemical	Gene	START_ENTITY|nsubj|Determination Determination|nmod|END_ENTITY	Determination of the prorelaxin nucleotide sequence and expression of prorelaxin messenger ribonucleic acid in the golden_hamster .
19450841	0	nucleotide	7,17	prostate_specific_antigen	81,106	nucleotide	prostate specific antigen	D009711	354	Chemical	Gene	START_ENTITY|nmod|level level|compound|END_ENTITY	Single nucleotide polymorphisms and the likelihood of prostate_cancer at a given prostate_specific_antigen level .
2991887	0	nucleotide	4,14	protein_C	46,55	nucleotide	protein C	CHEBI:36976	5624	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The nucleotide sequence of the gene for human protein_C .
175844	0	nucleotide	111,121	protein_kinase	85,99	nucleotide	protein kinase	CHEBI:36976	64030(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Effect of adenosine_3 ' ,5 ' - cyclic_monophosphate derivatives on alpha-amylase release , protein_kinase and cyclic nucleotide phosphodiesterase activity from rat parotid tissue .
15229188	0	nucleotide	7,17	protein_tyrosine_phosphatase_1beta	35,69	nucleotide	protein tyrosine phosphatase 1beta	CHEBI:36976	5770	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Single nucleotide polymorphisms in protein_tyrosine_phosphatase_1beta -LRB- PTPN1 -RRB- are associated with essential hypertension and obesity .
15576297	0	nucleotide	98,108	prothrombin	39,50	nucleotide	prothrombin	CHEBI:36976	2147	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|compound|END_ENTITY	Rapid combined genotyping of factor V , prothrombin and methylenetetrahydrofolate_reductase single nucleotide polymorphisms using minor groove binding DNA oligonucleotides -LRB- MGB probes -RRB- and real-time polymerase chain reaction .
24984162	0	nucleotide	36,46	pulmonary_surfactant_protein_A	64,94	nucleotide	pulmonary surfactant protein A	CHEBI:36976	653509	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Correlation analysis between single nucleotide polymorphisms of pulmonary_surfactant_protein_A gene and pulmonary_tuberculosis in the Han population in China .
21664930	0	nucleotide	9,19	quinolone_resistance_gene	34,59	nucleotide	quinolone resistance gene	CHEBI:36976	6875946(Tax:644)	Chemical	Gene	sequence|compound|START_ENTITY sequence|nmod|END_ENTITY	Complete nucleotide sequence of a quinolone_resistance_gene -LRB- qnrS2 -RRB- carrying plasmid of Aeromonas_hydrophila isolated from fish .
10847586	3	nucleotide	693,703	rat	723,726	nucleotide	NPY	CHEBI:36976	24604(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|gene gene|amod|END_ENTITY	In this study , we isolated and characterized a nuclear protein that is bound to NGF-response elements -LRB- NGFRE -RRB- that lie between nucleotide -87 and -33 of the rat NPY promoter gene .
9023342	0	nucleotide	32,42	receptor	43,51	nucleotide	receptor	CHEBI:36976	18436(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Transient up-regulation of P2Y2 nucleotide receptor mRNA expression is an immediate early gene response in activated thymocytes .
11872693	0	nucleotide	29,39	resistin	61,69	nucleotide	resistin	CHEBI:36976	56729	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Systematic search for single nucleotide polymorphisms in the resistin gene : the absence of evidence for the association of three identified single nucleotide polymorphisms with Japanese type 2 diabetes .
12962493	0	nucleotide	44,54	retina_specific_ABC_transporter	85,116	nucleotide	retina specific ABC transporter	CHEBI:36976	24	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Functional analysis of genetic mutations in nucleotide binding domain 2 of the human retina_specific_ABC_transporter .
11450851	0	nucleotide	7,17	retinoid_X_receptor_alpha	49,74	nucleotide	retinoid X receptor alpha	CHEBI:36976	6256	Chemical	Gene	START_ENTITY|dobj|polymorphisms polymorphisms|nmod|END_ENTITY	Single nucleotide polymorphisms of RXRA encoding retinoid_X_receptor_alpha .
7563054	0	nucleotide	48,58	ribonuclease_A	74,88	nucleotide	ribonuclease A	CHEBI:36976	282340(Tax:9913)	Chemical	Gene	specificity|amod|START_ENTITY specificity|nmod|END_ENTITY	A residue to residue hydrogen bond mediates the nucleotide specificity of ribonuclease_A .
22608881	0	nucleotide	7,17	sFRP4	35,40	nucleotide	sFRP4	CHEBI:36976	6424	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Single nucleotide polymorphisms in sFRP4 are associated with bone and body composition related parameters in Danish but not in Belgian men .
24133576	0	nucleotide	19,29	secreted_frizzled_related_protein_1	47,82	nucleotide	secreted frizzled related protein 1	CHEBI:36976	6422	Chemical	Gene	polymorphisms|compound|START_ENTITY Role|nmod|polymorphisms Role|nmod|END_ENTITY	Role of two single nucleotide polymorphisms in secreted_frizzled_related_protein_1 and bladder_cancer risk .
19845785	0	nucleotide	7,17	serotonin_transporter	39,60	nucleotide	serotonin transporter	CHEBI:36976	6532	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Single nucleotide polymorphisms of the serotonin_transporter gene in migraine -- an association study .
2558975	0	nucleotide	53,63	serum_amyloid_A	10,25	nucleotide	serum amyloid A	CHEBI:36976	6287	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|dep|sequence	The human serum_amyloid_A -LRB- SAA -RRB- - encoding gene GSAA1 : nucleotide sequence and possible autocrine-collagenase-inducer function .
1985920	0	nucleotide	25,35	sterol_carrier_protein_2	58,82	nucleotide	sterol carrier protein 2	CHEBI:36976	25541(Tax:10116)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	Cloning , expression , and nucleotide sequence of rat liver sterol_carrier_protein_2 cDNAs .
792815	1	nucleotide	97,107	tRNAPhe1	126,134	nucleotide	tRNAPhe1	CHEBI:36976	3023342(Tax:288681)	Chemical	Gene	geometry|amod|START_ENTITY geometry|nmod|END_ENTITY	The -LRB- omega , omega -RRB- plot and its correlation to the nucleotide geometry in yeast tRNAPhe1 .
3921221	0	nucleotide	4,14	tRNAVal3a	27,36	nucleotide	tRNAVal3a	CHEBI:36976	3772316(Tax:7227)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|END_ENTITY	The nucleotide sequence of tRNAVal3a and tRNAVal3b from Drosophila_melanogaster .
19571223	0	nucleotide	21,31	tas1r1	55,61	nucleotide	tas1r1	D009711	80835	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Nonsynonymous single nucleotide polymorphisms in human tas1r1 , tas1r3 , and mGluR1 and individual taste sensitivity to glutamate .
8163485	0	nucleotide	39,49	terminal_deoxynucleotidyl_transferase	74,111	nucleotide	terminal deoxynucleotidyl transferase	CHEBI:36976	1791	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Mutational analysis of residues in the nucleotide binding domain of human terminal_deoxynucleotidyl_transferase .
14719174	0	nucleotide	21,31	thrombin_activatable_fibrinolysis_inhibitor	53,96	nucleotide	thrombin activatable fibrinolysis inhibitor	CHEBI:36976	1361	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	The impact of single nucleotide polymorphisms of the thrombin_activatable_fibrinolysis_inhibitor -LRB- TAFI -RRB- gene on TAFI antigen levels in healthy children and pediatric oncology patients .
24747042	0	nucleotide	7,17	thymidine_kinase	35,51	nucleotide	thymidine kinase	CHEBI:36976	24271467	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|genes genes|compound|END_ENTITY	Single nucleotide polymorphisms of thymidine_kinase and DNA polymerase genes in clinical herpes_simplex_virus_type_1 isolates associated with different resistance phenotypes .
3027984	0	nucleotide	32,42	thymidine_kinase	14,30	nucleotide	thymidine kinase	CHEBI:36976	1486634(Tax:10261)	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|dep|sequence	Fowlpox_virus thymidine_kinase : nucleotide sequence and relationships to other thymidine_kinases .
15598685	0	nucleotide	40,50	thyroid_hormone_receptor_beta	58,87	nucleotide	thyroid hormone receptor beta	CHEBI:36976	7068	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	A de novo mutation in an already mutant nucleotide of the thyroid_hormone_receptor_beta gene perpetuates resistance to thyroid hormone .
22085193	0	nucleotide	7,17	toll-like_receptor-4	35,55	nucleotide	toll-like receptor-4	CHEBI:36976	7099	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Single nucleotide polymorphisms of toll-like_receptor-4 protect against acne_conglobata .
20445564	0	nucleotide	7,17	toll-like_receptor_6	35,55	nucleotide	toll-like receptor 6	CHEBI:36976	10333	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Single nucleotide polymorphisms in toll-like_receptor_6 are associated with altered lipopeptide - and mycobacteria-induced interleukin-6 secretion .
2054387	0	nucleotide	4,14	transferrin	40,51	nucleotide	transferrin	CHEBI:36976	100009267(Tax:9986)	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|cDNA cDNA|compound|END_ENTITY	The nucleotide sequence of rabbit liver transferrin cDNA .
7717992	0	nucleotide	31,41	transferrin	18,29	nucleotide	transferrin	CHEBI:36976	24825(Tax:10116)	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|dep|sequence	Rat mammary-gland transferrin : nucleotide sequence , phylogenetic analysis and glycan structure .
2060757	0	nucleotide	16,26	tuf	62,65	nucleotide	tuf	CHEBI:36976	25040336	Chemical	Gene	sequence|amod|START_ENTITY sequence|nmod|gene gene|compound|END_ENTITY	Analysis of the nucleotide sequence of the Mycoplasma_hominis tuf gene and its flanking region .
22947907	0	nucleotide	22,32	tumor_necrosis_factor-a	60,83	nucleotide	tumor necrosis factor-a	CHEBI:36976	7124	Chemical	Gene	Association|nmod|START_ENTITY polymorphisms|nsubj|Association polymorphisms|nmod|END_ENTITY	Association of single nucleotide polymorphisms in the human tumor_necrosis_factor-a and interleukin_1-b genes in patients with pre-eclampsia .
11759867	0	nucleotide	19,29	tumor_necrosis_factor-alpha	73,100	nucleotide	tumor necrosis factor-alpha	CHEBI:36976	7124	Chemical	Gene	Analysis|nmod|START_ENTITY polymorphisms|nsubj|Analysis polymorphisms|nmod|5 5|dep|region region|nmod|gene gene|amod|END_ENTITY	Analysis of single nucleotide polymorphisms in the 5 ' - flanking region of tumor_necrosis_factor-alpha gene in Japanese patients with early-onset periodontitis .
15533517	0	nucleotide	54,64	tumor_necrosis_factor-alpha	118,145	nucleotide	tumor necrosis factor-alpha	CHEBI:36976	7124	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Association of bladder_tumors and GA genotype of -308 nucleotide in tumor_necrosis_factor-alpha promoter with greater tumor_necrosis_factor-alpha expression .
15533517	0	nucleotide	54,64	tumor_necrosis_factor-alpha	68,95	nucleotide	tumor necrosis factor-alpha	CHEBI:36976	7124	Chemical	Gene	START_ENTITY|nmod|promoter promoter|amod|END_ENTITY	Association of bladder_tumors and GA genotype of -308 nucleotide in tumor_necrosis_factor-alpha promoter with greater tumor_necrosis_factor-alpha expression .
15900501	0	nucleotide	7,17	tumor_necrosis_factor-alpha	80,107	nucleotide	tumor necrosis factor-alpha	CHEBI:36976	715467(Tax:9544)	Chemical	Gene	polymorphisms|nsubj|START_ENTITY polymorphisms|nmod|region region|nmod|gene gene|amod|END_ENTITY	Single nucleotide polymorphisms within the promoter region of the rhesus_monkey tumor_necrosis_factor-alpha gene .
16970270	0	nucleotide	50,60	tumor_necrosis_factor-alpha	105,132	nucleotide	tumor necrosis factor-alpha	CHEBI:36976	7124	Chemical	Gene	associations|nmod|START_ENTITY Evaluation|nmod|associations polymorphisms|nsubj|Evaluation polymorphisms|nmod|region region|nmod|gene gene|amod|END_ENTITY	Evaluation of the associations between the single nucleotide polymorphisms of the promoter region of the tumor_necrosis_factor-alpha gene and nasopharyngeal_carcinoma .
17589947	0	nucleotide	111,121	tumor_necrosis_factor-alpha	76,103	nucleotide	tumor necrosis factor-alpha	D009711	7124	Chemical	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Role of matrix metalloproteinase , tissue inhibitor of metalloproteinase and tumor_necrosis_factor-alpha single nucleotide gene polymorphisms in inflammatory_bowel_disease .
18698679	0	nucleotide	7,17	tumor_necrosis_factor-alpha	38,65	nucleotide	tumor necrosis factor-alpha	D009711	7124	Chemical	Gene	polymorphism|compound|START_ENTITY polymorphism|nmod|gene gene|amod|END_ENTITY	Single nucleotide polymorphism in the tumor_necrosis_factor-alpha gene affects inflammatory_bowel_diseases risk .
23717605	0	nucleotide	7,17	tumor_necrosis_factor-alpha	39,66	nucleotide	tumor necrosis factor-alpha	CHEBI:36976	7124	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|region region|amod|END_ENTITY	Single nucleotide polymorphisms in the tumor_necrosis_factor-alpha gene promoter region alter the risk of psoriasis_vulgaris and psoriatic_arthritis : a meta-analysis .
9820599	0	nucleotide	35,45	tumor_necrosis_factor-alpha	73,100	nucleotide	tumor necrosis factor-alpha	CHEBI:36976	7124	Chemical	Gene	polymorphisms|compound|START_ENTITY Identification|nmod|polymorphisms Identification|nmod|promoter promoter|amod|END_ENTITY	Identification of three new single nucleotide polymorphisms in the human tumor_necrosis_factor-alpha gene promoter .
12597245	0	nucleotide	7,17	vascular_endothelial_growth_factor	65,99	nucleotide	vascular endothelial growth factor	CHEBI:36976	7422	Chemical	Gene	polymorphisms|nsubj|START_ENTITY polymorphisms|nmod|region region|nmod|gene gene|compound|END_ENTITY	Single nucleotide polymorphisms in the 3 ' untranslated region of vascular_endothelial_growth_factor gene in Japanese population with or without renal_cell_carcinoma .
20618614	0	nucleotide	7,17	vascular_endothelial_growth_factor	39,73	nucleotide	vascular endothelial growth factor	CHEBI:36976	7422	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	Single nucleotide polymorphisms of the vascular_endothelial_growth_factor gene associated with incidence of oral_squamous_cell_carcinoma .
21138680	0	nucleotide	40,50	vascular_endothelial_growth_factor	68,102	nucleotide	vascular endothelial growth factor	CHEBI:36976	7422	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|gene gene|compound|END_ENTITY	-LSB- A study on relationship between single nucleotide polymorphisms of vascular_endothelial_growth_factor gene and susceptibility to systemic_lupus_erythematosus in China north Han population -RSB- .
24008569	0	nucleotide	13,23	vascular_endothelial_growth_factor	45,79	nucleotide	vascular endothelial growth factor	CHEBI:36976	7422	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|nmod|END_ENTITY	Three single nucleotide polymorphisms of the vascular_endothelial_growth_factor -LRB- VEGF -RRB- gene and glioma risk in a Chinese population .
9777367	0	nucleotide	42,52	vascular_endothelial_growth_factor	6,40	nucleotide	vascular endothelial growth factor	CHEBI:36976	443103(Tax:9940)	Chemical	Gene	sequence|amod|START_ENTITY END_ENTITY|dep|sequence	Ovine vascular_endothelial_growth_factor : nucleotide sequence and expression in fetal tissues .
10725660	0	nucleotide	10,20	xpc	40,43	nucleotide	xpc	CHEBI:36976	22591(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Defective nucleotide excision repair in xpc mutant mice and its association with cancer predisposition .
15911612	0	nucleotide_sugar	61,77	SLC35B4	30,37	nucleotide sugar	SLC35B4	CHEBI:25609	84912	Chemical	Gene	transporter|compound|START_ENTITY encodes|dobj|transporter encodes|nsubj|END_ENTITY	The human solute carrier gene SLC35B4 encodes a bifunctional nucleotide_sugar transporter with specificity for UDP-xylose and UDP-N-acetylglucosamine .
11694445	0	nucleotide_triphosphates	93,117	mucin	34,39	nucleotide triphosphates	mucin	null	100508689	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|expression expression|compound|END_ENTITY	Differential regulation of airway mucin gene expression and mucin secretion by extracellular nucleotide_triphosphates .
23306083	0	nucleotide_uridine_diphosphate	61,91	Intestinal_alkaline_phosphatase	0,31	nucleotide uridine diphosphate	Intestinal alkaline phosphatase	null	11648(Tax:10090)	Chemical	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Intestinal_alkaline_phosphatase inhibits the proinflammatory nucleotide_uridine_diphosphate .
8282779	0	nucleotides	18,29	AE1	55,58	nucleotides	AE1	MESH:D009711	6521	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Duplication of 10 nucleotides in the erythroid band 3 -LRB- AE1 -RRB- gene in a kindred with hereditary_spherocytosis and band 3 protein deficiency -LRB- band 3PRAGUE -RRB- .
14131	0	nucleotides	11,22	ATPase	58,64	nucleotides	ATPase	MESH:D009711	1769	Chemical	Gene	Binding|nmod|START_ENTITY END_ENTITY|nsubj|Binding	Binding of nucleotides to purified coupling factor-latent ATPase from Mycobacterium phlei .
7805855	0	nucleotides	58,69	EF-2	48,52	nucleotides	EF-2	MESH:D009711	1938	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of phosphorylated elongation factor EF-2 with nucleotides and ribosomes .
17023685	0	nucleotides	11,22	GlcNAc_2-epimerase	56,74	nucleotides	GlcNAc 2-epimerase	MESH:D009711	5973	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of nucleotides on the interaction of renin with GlcNAc_2-epimerase -LRB- renin_binding_protein , RnBP -RRB- .
7867782	0	nucleotides	83,94	GroES	57,62	nucleotides	GroES	MESH:D009711	13876916	Chemical	Gene	affinity|nmod|START_ENTITY has|dobj|affinity has|nsubj|END_ENTITY	GroES and the chaperonin-assisted protein folding cycle : GroES has no affinity for nucleotides .
8786080	0	nucleotides	19,30	L1CAM	38,43	nucleotides	L1CAM	MESH:D009711	3897	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	A deletion of five nucleotides in the L1CAM gene in a Japanese family with X-linked_hydrocephalus .
17142918	0	nucleotides	89,100	MTH1	56,60	nucleotides	MTH1	MESH:D009711	4521	Chemical	Gene	complexed|nmod|START_ENTITY complexed|nsubj|analysis analysis|nmod|END_ENTITY	Crystallization and preliminary X-ray analysis of human MTH1 complexed with two oxidized nucleotides , 8-oxo-dGMP and 2-oxo-dATP .
17606897	0	nucleotides	37,48	Otopetrin_1	0,11	nucleotides	Otopetrin 1	MESH:D009711	133060	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Otopetrin_1 activation by purinergic nucleotides regulates intracellular calcium .
14689471	0	nucleotides	106,117	P2Y1	128,132	nucleotides	P2Y1	MESH:D009711	25265(Tax:10116)	Chemical	Gene	START_ENTITY|acl|acting acting|nmod|END_ENTITY	Mechanically evoked reflex electrogenic chloride secretion in rat distal colon is triggered by endogenous nucleotides acting at P2Y1 , P2Y2 , and P2Y4 receptors .
24816122	0	nucleotides	21,32	P2Y2	0,4	nucleotides	P2Y2	MESH:D009711	18442(Tax:10090)	Chemical	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	P2Y2 R activation by nucleotides promotes skin wound-healing process .
25156554	0	nucleotides	28,39	P2Y2	0,4	nucleotides	P2Y2	MESH:D009711	5029	Chemical	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	P2Y2 receptor activation by nucleotides released from highly metastatic breast_cancer cells increases_tumor growth and invasion via crosstalk with endothelial cells .
25238333	0	nucleotides	20,31	P2Y2R	0,5	nucleotides	P2Y2R	MESH:D009711	5029	Chemical	Gene	activation|nmod|START_ENTITY activation|nummod|END_ENTITY	P2Y2R activation by nucleotides released from the highly metastatic breast_cancer cell MDA-MB-231 contributes to pre-metastatic niche formation by mediating lysyl_oxidase secretion , collagen crosslinking , and monocyte recruitment .
8702787	0	nucleotides	46,57	Rab5	27,31	nucleotides	Rab5	MESH:D009711	5868	Chemical	Gene	Kinetics|nmod|START_ENTITY Kinetics|nmod|END_ENTITY	Kinetics of interaction of Rab5 and Rab7 with nucleotides and magnesium ions .
17686958	0	nucleotides	26,37	SGK1	18,22	nucleotides	SGK1	MESH:D009711	20393(Tax:10090)	Chemical	Gene	Downregulation|nmod|START_ENTITY Downregulation|nmod|END_ENTITY	Downregulation of SGK1 by nucleotides in renal tubular epithelial cells .
6259003	0	nucleotides	8,19	TRH-receptor	29,41	nucleotides	TRH-receptor	MESH:D009711	443425(Tax:9940)	Chemical	Gene	modulate|nsubj|START_ENTITY modulate|dobj|END_ENTITY	Guanine nucleotides modulate TRH-receptor binding in sheep anterior pituitary .
11279083	0	nucleotides	29,40	cystic_fibrosis_transmembrane_conductance_regulator	86,137	nucleotides	cystic fibrosis transmembrane conductance regulator	MESH:D009711	1080	Chemical	Gene	interactions|nmod|START_ENTITY interactions|nmod|END_ENTITY	Differential interactions of nucleotides at the two nucleotide_binding_domains of the cystic_fibrosis_transmembrane_conductance_regulator .
7687995	0	nucleotides	15,26	cystic_fibrosis_transmembrane_conductance_regulator	52,103	nucleotides	cystic fibrosis transmembrane conductance regulator	MESH:D009711	1080	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of nucleotides with membrane-associated cystic_fibrosis_transmembrane_conductance_regulator .
14610168	0	nucleotides	10,21	eIF4G	156,161	nucleotides	eIF4G	MESH:D009711	1981	Chemical	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	Conserved nucleotides within the J domain of the encephalomyocarditis_virus internal ribosome entry site are required for activity and for interaction with eIF4G .
9129831	0	nucleotides	27,38	methionyl_tRNA_synthetase	48,73	nucleotides	methionyl tRNA synthetase	MESH:D009711	4141	Chemical	Gene	START_ENTITY|acl|bound bound|xcomp|END_ENTITY	Adenosine conformations of nucleotides bound to methionyl_tRNA_synthetase by transferred nuclear Overhauser effect spectroscopy .
7918498	0	nucleotides	25,36	myosin	46,52	nucleotides	myosin	MESH:D009711	79784	Chemical	Gene	START_ENTITY|acl|bound bound|nmod|END_ENTITY	Quenching of fluorescent nucleotides bound to myosin : a probe of the active-site conformation .
6257510	0	nucleotides	69,80	vitellogenin	96,108	nucleotides	vitellogenin	MESH:D009711	424533(Tax:9031)	Chemical	Gene	START_ENTITY|nmod|mRNA mRNA|compound|END_ENTITY	Characterization of cloned complementary DNA covering more than 6000 nucleotides -LRB- 97 % -RRB- of avian vitellogenin mRNA .
3392030	0	numatrin	18,26	B23	122,125	numatrin	B23	null	4869	Chemical	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of numatrin , the nuclear matrix protein associated with induction of mitogenesis , as the nucleolar protein B23 .
16505116	0	nutlin	37,43	murine_double_minute_2	61,83	nutlin	murine double minute 2	CHEBI:46741	17246(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Radiosensitization of lung_cancer by nutlin , an inhibitor of murine_double_minute_2 .
22912717	0	nutlin-3	102,110	HDM2	81,85	nutlin-3	HDM2	MESH:C482205	4193	Chemical	Gene	inhibited|advcl|START_ENTITY inhibited|nsubj|Binding Binding|nmod|Translationally_Controlled_Tumour_Protein Translationally_Controlled_Tumour_Protein|nmod|domain domain|nmod|END_ENTITY	Binding of Translationally_Controlled_Tumour_Protein to the N-terminal domain of HDM2 is inhibited by nutlin-3 .
17138942	0	nutlin-3	47,55	MDM2	31,35	nutlin-3	MDM2	MESH:C482205	4193	Chemical	Gene	antagonist|xcomp|START_ENTITY antagonist|nsubj|activity activity|nmod|END_ENTITY	Antiangiogenic activity of the MDM2 antagonist nutlin-3 .
17440969	0	nutlin-3	32,40	MDM2	16,20	nutlin-3	MDM2	MESH:C482205	4193	Chemical	Gene	antagonist|xcomp|START_ENTITY antagonist|nsubj|Analysis Analysis|nmod|END_ENTITY	Analysis of the MDM2 antagonist nutlin-3 in human prostate_cancer cells .
18273046	0	nutlin-3	16,24	MDM2	147,151	nutlin-3	MDM2	MESH:C482205	17246(Tax:10090)	Chemical	Gene	MDM2|amod|START_ENTITY inducer|nsubj|MDM2 inducer|nmod|END_ENTITY	MDM2 antagonist nutlin-3 is a potent inducer of apoptosis in pediatric acute_lymphoblastic_leukemia cells with wild-type p53 and overexpression of MDM2 .
19188164	0	nutlin-3	16,24	MDM2	0,4	nutlin-3	MDM2	MESH:C482205	4193	Chemical	Gene	displays|amod|START_ENTITY displays|nummod|END_ENTITY	MDM2 antagonist nutlin-3 displays antiproliferative and proapoptotic activity in mantle_cell_lymphoma .
19903807	0	nutlin-3	52,60	MDM2	36,40	nutlin-3	MDM2	MESH:C482205	17246(Tax:10090)	Chemical	Gene	antagonist|xcomp|START_ENTITY antagonist|nsubj|activity activity|nmod|END_ENTITY	Antitumor activity of the selective MDM2 antagonist nutlin-3 against chemoresistant neuroblastoma with wild-type p53 .
21205074	0	nutlin-3	64,72	MDM2	49,53	nutlin-3	MDM2	MESH:C482205	4193	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|Potent Potent|nmod|effects effects|nmod|END_ENTITY	Potent in vitro and in vivo antitumor effects of MDM2 inhibitor nutlin-3 in gastric_cancer cells .
21460101	0	nutlin-3	103,111	MDM2	87,91	nutlin-3	MDM2	MESH:C482205	4193	Chemical	Gene	antagonist|xcomp|START_ENTITY antagonist|nsubj|analysis analysis|nmod|pathway pathway|nmod|cells cells|acl|using using|dobj|END_ENTITY	Functional analysis of the p53 pathway in neuroblastoma cells using the small-molecule MDM2 antagonist nutlin-3 .
22170099	0	nutlin-3	73,81	MDM2	58,62	nutlin-3	MDM2	MESH:C482205	4193	Chemical	Gene	results|amod|START_ENTITY inhibitor|dobj|results inhibitor|nsubj|Adaptation Adaptation|nmod|cells cells|nmod|entities entities|nmod|END_ENTITY	Adaptation of cancer cells from different entities to the MDM2 inhibitor nutlin-3 results in the emergence of p53-mutated multi-drug-resistant cancer cells .
22343310	0	nutlin-3	19,27	MDM2	0,4	nutlin-3	MDM2	MESH:C482205	4193	Chemical	Gene	antagonism|nmod|START_ENTITY antagonism|compound|END_ENTITY	MDM2 antagonism by nutlin-3 induces death in human medulloblastoma cells .
22578852	0	nutlin-3	58,66	MDM2	42,46	nutlin-3	MDM2	MESH:C482205	4193	Chemical	Gene	Comparison|amod|START_ENTITY Comparison|nmod|effects effects|nmod|END_ENTITY	Comparison of the antitumor effects of an MDM2 inhibitor , nutlin-3 , in feline lymphoma cell lines with or without p53 mutation .
19788889	0	nutlin-3	42,50	Mdm2	27,31	nutlin-3	Mdm2	MESH:C482205	4193	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|response response|nmod|END_ENTITY	DNA damage response to the Mdm2 inhibitor nutlin-3 .
19509161	0	nutlin-3	30,38	p53	15,18	nutlin-3	p53	MESH:C482205	7157	Chemical	Gene	pathway|nmod|START_ENTITY pathway|compound|END_ENTITY	Restoration of p53 pathway by nutlin-3 induces cell cycle arrest and apoptosis in human rhabdomyosarcoma cells .
20331637	0	nutlin-3	100,108	p53	58,61	nutlin-3	p53	MESH:C482205	7157	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Low-dose mithramycin exerts its anticancer effect via the p53 signaling pathway and synergizes with nutlin-3 in gynecologic_cancers .
23831464	0	nystatin	79,87	CC_chemokine_ligand_2	27,48	nystatin	CC chemokine ligand 2	MESH:D009761	6347	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of CC_chemokine_ligand_2 and CXCL8 by antifungal agent nystatin in macrophages .
24009857	0	nystatin	35,43	macrophage_inflammatory_protein-1	66,99	nystatin	macrophage inflammatory protein-1	MESH:D009761	79109	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	The cholesterol-binding antibiotic nystatin induces expression of macrophage_inflammatory_protein-1 in macrophages .
11398193	0	o-aminoazotoluene	63,80	HNF3gamma	36,45	o-aminoazotoluene	HNF3gamma	MESH:D009762	15377(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nmod|effect	Involvement of transcription factor HNF3gamma in the effect of o-aminoazotoluene on glucocorticoid induction of tyrosine_aminotransferase in mice sensitive to its hepatocarcinogenic action .
21397024	0	o-aminobenzamide	33,49	HDAC	50,54	o-aminobenzamide	HDAC	null	9734	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Prolonged treatment with pimelic o-aminobenzamide HDAC inhibitors ameliorates the disease phenotype of a Friedreich_ataxia mouse model .
21715165	0	o-aminobenzamide	34,50	Hsp90	51,56	o-aminobenzamide	Hsp90	null	111058(Tax:10090)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Discovery of a stable macrocyclic o-aminobenzamide Hsp90 inhibitor which significantly decreases tumor volume in a mouse xenograft model .
415733	0	o-aminophenol	83,96	UDP-glucuronosyltransferase	38,65	o-aminophenol	UDP-glucuronosyltransferase	MESH:C027667	24862(Tax:10116)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|activity activity|amod|END_ENTITY	Regulation of onset of development of UDP-glucuronosyltransferase activity towards o-aminophenol by glucocorticoids in late-foetal rat liver in utero .
21810487	0	o-aminophenols	23,37	tyrosinase	70,80	o-aminophenols	tyrosinase	null	7299	Chemical	Gene	oxidation|nmod|START_ENTITY oxidation|nmod|END_ENTITY	Catalytic oxidation of o-aminophenols and aromatic_amines by mushroom tyrosinase .
20695501	0	o-carboranylphenoxyacetanilide	47,77	HIF-1alpha	82,92	o-carboranylphenoxyacetanilide	HIF-1alpha	null	3091	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Identification of HSP60 as a primary target of o-carboranylphenoxyacetanilide , an HIF-1alpha inhibitor .
19047003	0	o-diphenols	14,25	tyrosinase	50,60	o-diphenols	tyrosinase	null	7299	Chemical	Gene	Production|nmod|START_ENTITY END_ENTITY|nsubj|Production	Production of o-diphenols by immobilized mushroom tyrosinase .
1864847	0	o-halogenophenol	17,33	salicylate_hydroxylase	55,77	o-halogenophenol	salicylate hydroxylase	null	1343177(Tax:303)	Chemical	Gene	Hydroxylation|nmod|START_ENTITY Hydroxylation|nmod|END_ENTITY	Hydroxylation of o-halogenophenol and o-nitrophenol by salicylate_hydroxylase .
2281039	0	o-naphthoquinone	29,45	5-lipoxygenase	46,60	o-naphthoquinone	5-lipoxygenase	MESH:C040756	240	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Pharmacokinetic screening of o-naphthoquinone 5-lipoxygenase inhibitors .
23912027	0	o-naphtoquinone	8,23	N-cadherin	33,43	o-naphtoquinone	N-cadherin	null	1000	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	A novel o-naphtoquinone inhibits N-cadherin expression and blocks_melanoma cell invasion via AKT signaling .
24679008	0	obatoclax_mesylate	46,64	Bcl-2	30,35	obatoclax mesylate	Bcl-2	null	596	Chemical	Gene	START_ENTITY|nsubj|study study|nmod|inhibitor inhibitor|compound|END_ENTITY	A phase I/II study of the pan Bcl-2 inhibitor obatoclax_mesylate plus bortezomib for relapsed or refractory_mantle_cell_lymphoma .
20624436	0	obestatin	39,48	neuropeptide_W	15,29	obestatin	neuropeptide W	MESH:D054439	259224(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Association Association|nmod|END_ENTITY	Association of neuropeptide_W , but not obestatin , with energy intake and endocrine status in Zucker rats .
9587020	0	obidoxime	24,33	acetylcholinesterase	85,105	obidoxime	acetylcholinesterase	MESH:D009768	43	Chemical	Gene	potency|nmod|START_ENTITY potency|nmod|END_ENTITY	Reactivating potency of obidoxime , pralidoxime , HI 6 and HL 7 in human erythrocyte acetylcholinesterase inhibited by highly toxic organophosphorus compounds .
12029385	0	ochratoxin_A	47,59	Hsp70	14,19	ochratoxin A	Hsp70	MESH:C025589	266759(Tax:10116)	Chemical	Gene	exposed|nmod|START_ENTITY exposed|nsubj|Expression Expression|nmod|END_ENTITY	Expression of Hsp70 in kidney cells exposed to ochratoxin_A .
21778665	0	ochratoxin_A	71,83	NPT4	40,44	ochratoxin A	NPT4	MESH:C025589	10786	Chemical	Gene	transport|nmod|START_ENTITY mediates|dobj|transport mediates|nsubj|END_ENTITY	A novel human organic anion transporter NPT4 mediates the transport of ochratoxin_A .
24448208	0	ochratoxin_A	30,42	Nrf2	49,53	ochratoxin A	Nrf2	MESH:C025589	4780	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|amod|END_ENTITY	A review of the evidence that ochratoxin_A is an Nrf2 inhibitor : implications for nephrotoxicity and renal_carcinogenicity .
11998373	0	ochratoxin_A	40,52	THP-1	135,140	ochratoxin A	THP-1	MESH:C025589	2736	Chemical	Gene	influence|nmod|START_ENTITY studies|nmod|influence studies|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- In vitro studies into the influence of ochratoxin_A on the production of tumor_necrosis_factor_alpha by the human monocytic cell line THP-1 -RSB- .
12505377	0	ochratoxin_A	25,37	THP-1	89,94	ochratoxin A	THP-1	MESH:C025589	2736	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of the mycotoxin ochratoxin_A and some of its metabolites on the human cell line THP-1 .
12063169	0	ochratoxin_A	62,74	organic_anion_transporter_4	14,41	ochratoxin A	organic anion transporter 4	MESH:C025589	55867	Chemical	Gene	transport|nmod|START_ENTITY Role|nmod|transport Role|nmod|END_ENTITY	Role of human organic_anion_transporter_4 in the transport of ochratoxin_A .
2167054	0	ochratoxin_A	15,27	phenylalanine_hydroxylase	47,72	ochratoxin A	phenylalanine hydroxylase	MESH:C025589	24616(Tax:10116)	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	The myocotoxin ochratoxin_A is a substrate for phenylalanine_hydroxylase in isolated rat hepatocytes and in vivo .
11998373	0	ochratoxin_A	40,52	tumor_necrosis_factor_alpha	74,101	ochratoxin A	tumor necrosis factor alpha	MESH:C025589	7124	Chemical	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	-LSB- In vitro studies into the influence of ochratoxin_A on the production of tumor_necrosis_factor_alpha by the human monocytic cell line THP-1 -RSB- .
6359816	0	octachlorostyrene	94,111	cytochrome_P-450	10,26	octachlorostyrene	cytochrome P-450	MESH:C014138	25251(Tax:10116)	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|amod|END_ENTITY	Increased cytochrome_P-450 independent drug metabolism and mutagen activation in rat liver by octachlorostyrene .
9520339	0	octamethylcyclotetrasiloxane	14,42	UDP-glucuronosyltransferase	105,132	octamethylcyclotetrasiloxane	UDP-glucuronosyltransferase	MESH:C024064	24862(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inducer inducer|nmod|END_ENTITY	Evaluation of octamethylcyclotetrasiloxane -LRB- D4 -RRB- as an inducer of rat hepatic microsomal cytochrome_P450 , UDP-glucuronosyltransferase , and epoxide hydrolase : a 28-day inhalation study .
3149601	0	octanol	35,42	dehydrogenase	43,56	octanol	dehydrogenase	CHEBI:37868	33824(Tax:7227)	Chemical	Gene	locus|amod|START_ENTITY locus|amod|END_ENTITY	Changes in gene frequencies at the octanol dehydrogenase locus of Drosophila_melanogaster imposed by environmental ethanol .
24187534	0	octopamine	15,25	AmOA1	38,43	octopamine	AmOA1	MESH:D009655	406068(Tax:7460)	Chemical	Gene	START_ENTITY|dobj|expression expression|amod|1 1|dep|END_ENTITY	Apis_mellifera octopamine receptor 1 -LRB- AmOA1 -RRB- expression in antennal lobe networks of the honey_bee -LRB- Apis_mellifera -RRB- and fruit_fly -LRB- Drosophila_melanogaster -RRB- .
17201769	1	octopamine	144,154	BmOAR1	170,176	octopamine	BmOAR1	MESH:D009655	768089(Tax:7091)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	A cDNA encoding an octopamine -LRB- OA -RRB- receptor -LRB- BmOAR1 -RRB- was isolated from the nerve tissue of silkworm -LRB- Bombyx_mori -RRB- larvae .
23107737	0	octopamine	88,98	tyrosinase	115,125	octopamine	tyrosinase	MESH:D009655	7299	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|amod|END_ENTITY	Synthesis and structure-activity relationships and effects of phenylpropanoid_amides of octopamine and dopamine on tyrosinase inhibition and antioxidation .
17984930	0	octreotide	20,30	ACTH	12,16	octreotide	ACTH	MESH:D015282	5443	Chemical	Gene	Response|acl|START_ENTITY Response|nmod|END_ENTITY	Response of ACTH to octreotide in a probable corticotropic adenoma associated with Addison 's _ disease .
15046398	0	octreotide	14,24	Bax	76,79	octreotide	Bax	MESH:D015282	24887(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|protein protein|compound|END_ENTITY	The effect of octreotide and bromocriptine on expression of a pro-apoptotic Bax protein in rat prolactinoma .
10333081	0	octreotide	123,133	GLP-1	103,108	octreotide	GLP-1	MESH:D015282	2641	Chemical	Gene	secretion|nmod|START_ENTITY END_ENTITY|acl|secretion	Inhibition of insulin , glucose-dependent_insulinotropic_polypeptide -LRB- GIP -RRB- and glucagon-like_peptide-1 -LRB- GLP-1 -RRB- secretion by octreotide has no effect on post-heparin plasma lipoprotein_lipase activity .
8514980	0	octreotide	123,133	Growth_hormone	0,14	octreotide	Growth hormone	MESH:D015282	2688	Chemical	Gene	acromegaly|nmod|START_ENTITY treatment|nmod|acromegaly markers|nmod|treatment markers|amod|END_ENTITY	Growth_hormone and insulin-like_growth_factor-1 in blood and urine as response markers during treatment of acromegaly with octreotide : a double-blind placebo-controlled study .
9231841	0	octreotide	124,134	Growth_hormone	0,14	octreotide	Growth hormone	MESH:D015282	2688	Chemical	Gene	effects|nmod|START_ENTITY responses|dep|effects responses|compound|END_ENTITY	Growth_hormone and insulin-like_growth_factor_I responses to moderate submaximal acute physical exercise in man : effects of octreotide , a somatostatin analogue , administration .
2018120	0	octreotide	21,31	IGF-I	58,63	octreotide	IGF-I	MESH:D015282	24482(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|generation generation|compound|END_ENTITY	Inhibitory effect of octreotide on growth_hormone-induced IGF-I generation and organ growth in hypophysectomized rats .
19141605	0	octreotide	32,42	IGF1	46,50	octreotide	IGF1	MESH:D015282	3479	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|generation generation|compound|END_ENTITY	Pituitary-independent effect of octreotide on IGF1 generation .
11782718	0	octreotide	190,200	LAR	201,204	octreotide	LAR	MESH:D015282	5792	Chemical	Gene	-RSB-|amod|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Comparison between integrated 24-hour concentrations of growth hormone , insulin-like growth factor I and prolactin in acromegalic patients treated with octreotide and patients treated with octreotide LAR -RSB- .
26431407	0	octreotide	65,75	S0518	5,10	octreotide	S0518	MESH:D015282	1076952(Tax:198215)	Chemical	Gene	comparison|nmod|START_ENTITY END_ENTITY|dep|comparison	SWOG S0518 : phase III prospective randomized comparison of depot octreotide plus interferon_alpha-2b versus depot octreotide plus bevacizumab -LRB- NSC # 704865 -RRB- in advanced , poor prognosis carcinoid patients -LRB- NCT00569127 -RRB- .
15152279	0	octreotide	20,30	Somatostatin	0,12	octreotide	Somatostatin	MESH:D015282	6750	Chemical	Gene	START_ENTITY|nsubj|versus versus|compound|END_ENTITY	Somatostatin versus octreotide in the treatment of patients with gastrointestinal_and_pancreatic_fistulas .
20389030	0	octreotide	61,71	VEGF	0,4	octreotide	VEGF	MESH:D015282	22339(Tax:10090)	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|secretion secretion|compound|END_ENTITY	VEGF secretion by neuroendocrine_tumor cells is inhibited by octreotide and by inhibitors of the PI3K/AKT/mTOR pathway .
18636202	0	octreotide	134,144	Vascular_endothelial_growth_factor	0,34	octreotide	Vascular endothelial growth factor	MESH:D015282	7422	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|monitoring monitoring|amod|END_ENTITY	Vascular_endothelial_growth_factor monitoring in advanced hepatocellular_carcinoma patients treated with radiofrequency ablation plus octreotide : a single center experience .
1425066	0	octreotide	106,116	cholecystokinin	45,60	octreotide	cholecystokinin	MESH:D015282	885	Chemical	Gene	injection|nmod|START_ENTITY END_ENTITY|nmod|injection	Postprandial_gallbladder motility and plasma cholecystokinin at regular time intervals after injection of octreotide in acromegalics on long-term treatment .
20372113	0	octreotide	34,44	chromogranin_A	7,21	octreotide	chromogranin A	MESH:D015282	1113	Chemical	Gene	test|amod|START_ENTITY response|nmod|test response|compound|END_ENTITY	Plasma chromogranin_A response to octreotide test : prognostic value for clinical outcome in endocrine digestive tumors .
22110271	0	octreotide	11,21	glucose_transporter_type_2	25,51	octreotide	glucose transporter type 2	MESH:D015282	25351(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|amod|END_ENTITY	Effects of octreotide on glucose_transporter_type_2 expression in obese rat small intestine .
10396369	0	octreotide	107,117	growth_hormone	161,175	octreotide	growth hormone	MESH:D015282	2688	Chemical	Gene	injections|nmod|START_ENTITY LAR|nmod|injections injections|nmod|LAR Comparison|nmod|injections Comparison|dep|effects effects|nmod|markers markers|amod|END_ENTITY	Comparison of monthly intramuscular injections of Sandostatin LAR with multiple subcutaneous injections of octreotide in the treatment of acromegaly ; effects on growth_hormone and other markers of growth_hormone secretion .
10396369	0	octreotide	107,117	growth_hormone	197,211	octreotide	growth hormone	MESH:D015282	2688	Chemical	Gene	injections|nmod|START_ENTITY LAR|nmod|injections injections|nmod|LAR Comparison|nmod|injections Comparison|dep|effects effects|nmod|secretion secretion|amod|END_ENTITY	Comparison of monthly intramuscular injections of Sandostatin LAR with multiple subcutaneous injections of octreotide in the treatment of acromegaly ; effects on growth_hormone and other markers of growth_hormone secretion .
10591235	0	octreotide	31,41	growth_hormone	62,76	octreotide	growth hormone	MESH:D015282	2688	Chemical	Gene	analog|appos|START_ENTITY suppresses|nsubj|analog suppresses|ccomp|preserved preserved|nsubj|equivalently equivalently|amod|END_ENTITY	Synthetic somatostatin analog -LRB- octreotide -RRB- suppresses daytime growth_hormone secretion equivalently in young and older men : preserved pituitary responsiveness to somatostatin 's inhibition in aging .
1424206	0	octreotide	97,107	growth_hormone	38,52	octreotide	growth hormone	MESH:D015282	2688	Chemical	Gene	accumulation|amod|START_ENTITY cells|nmod|accumulation treatment|dep|cells treatment|nmod|END_ENTITY	Long-term in-vitro treatment of human growth_hormone -LRB- GH -RRB- - secreting pituitary_adenoma cells with octreotide causes accumulation of intracellular GH and GH mRNA levels .
1516889	0	octreotide	40,50	growth_hormone	54,68	octreotide	growth hormone	MESH:D015282	2688	Chemical	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	The effect of the somatostatin analogue octreotide on growth_hormone secretion in insulin-dependent diabetics without residual insulin secretion .
15237932	0	octreotide	107,117	growth_hormone	47,61	octreotide	growth hormone	MESH:D015282	2688	Chemical	Gene	secreting|nmod|START_ENTITY END_ENTITY|xcomp|secreting	Sustained improvement in vision in a recurrent growth_hormone secreting macroadenoma during treatment with octreotide in the absence of marked tumour shrinkage .
15256780	0	octreotide	121,131	growth_hormone	36,50	octreotide	growth hormone	MESH:D015282	2688	Chemical	Gene	surgery|amod|START_ENTITY treatment|nmod|surgery kilodalton|nmod|treatment kilodalton|dobj|END_ENTITY	Serum levels of 20 kilodalton human growth_hormone -LRB- 20K-hGH -RRB- in patients with acromegaly before and after treatment with octreotide and transsphenoidal surgery .
1543025	0	octreotide	90,100	growth_hormone	15,29	octreotide	growth hormone	MESH:D015282	2688	Chemical	Gene	shrinking|nmod|START_ENTITY pituitary_tumour|dep|shrinking pituitary_tumour|dep|END_ENTITY	Invasive mixed growth_hormone / prolactin secreting pituitary_tumour : complete shrinking by octreotide and bromocriptine , and lack of tumour growth relapse 20 months after octreotide withdrawal .
16328564	0	octreotide	46,56	growth_hormone	113,127	octreotide	growth hormone	MESH:D015282	2688	Chemical	Gene	dose|nmod|START_ENTITY responses|nmod|dose predict|nsubj|responses predict|xcomp|achieve achieve|dobj|levels levels|amod|END_ENTITY	Poor responses to a test dose of subcutaneous octreotide predict the need for adjuvant therapy to achieve ` safe ' growth_hormone levels .
1789059	0	octreotide	33,43	growth_hormone	92,106	octreotide	growth hormone	MESH:D015282	2688	Chemical	Gene	drugs|amod|START_ENTITY effects|nmod|drugs Dynamics|nmod|effects Dynamics|nmod|secretion secretion|amod|END_ENTITY	Dynamics of the acute effects of octreotide , bromocriptine and both drugs in combination on growth_hormone secretion in acromegaly .
1823080	0	octreotide	10,20	growth_hormone	32,46	octreotide	growth hormone	MESH:D015282	2688	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of octreotide on 24-hour growth_hormone and prolactin secretory patterns in acromegalics .
2180976	0	octreotide	41,51	growth_hormone	100,114	octreotide	growth hormone	MESH:D015282	2688	Chemical	Gene	START_ENTITY|nmod|concentrations concentrations|nmod|END_ENTITY	Effective clinical response to long term octreotide treatment , with reduced serum concentrations of growth_hormone , insulin-like_growth_factor-I , and the amino-terminal propeptide of type III procollagen in acromegaly .
22539587	0	octreotide	5,15	growth_hormone	113,127	octreotide	growth hormone	MESH:D015282	2688	Chemical	Gene	absorption|compound|START_ENTITY absorption|dep|pharmacokinetics pharmacokinetics|acl|parenteral parenteral|dobj|suppression suppression|amod|END_ENTITY	Oral octreotide absorption in human subjects : comparable pharmacokinetics to parenteral octreotide and effective growth_hormone suppression .
22539587	0	octreotide	88,98	growth_hormone	113,127	octreotide	growth hormone	MESH:D015282	2688	Chemical	Gene	suppression|amod|START_ENTITY suppression|amod|END_ENTITY	Oral octreotide absorption in human subjects : comparable pharmacokinetics to parenteral octreotide and effective growth_hormone suppression .
2506217	0	octreotide	24,34	growth_hormone	61,75	octreotide	growth hormone	MESH:D015282	2688	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dep|releasing releasing|nsubj|secretion secretion|nmod|END_ENTITY	The somatostatin analog octreotide inhibits the secretion of growth_hormone -LRB- GH -RRB- - releasing hormone , thyrotropin , and GH in man .
2537844	0	octreotide	32,42	growth_hormone	4,18	octreotide	growth hormone	MESH:D015282	2688	Chemical	Gene	responses|xcomp|START_ENTITY responses|nsubj|END_ENTITY	The growth_hormone responses to octreotide in acromegaly correlate with adenoma somatostatin receptor status .
7621570	0	octreotide	64,74	growth_hormone	93,107	octreotide	growth hormone	MESH:D015282	2688	Chemical	Gene	effect|appos|START_ENTITY effect|nmod|years years|nmod|secretion secretion|amod|END_ENTITY	The effect of a continuous infusion of a somatostatin analogue -LRB- octreotide -RRB- for two years on growth_hormone secretion and height prediction in tall children .
9053782	0	octreotide	38,48	growth_hormone	91,105	octreotide	growth hormone	MESH:D015282	81668(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|regulation regulation|amod|END_ENTITY	Effects of neonatal administration of octreotide , a long-lasting somatostatin analogue , on growth_hormone regulation in the adult rat .
9109848	0	octreotide	124,134	growth_hormone	33,47	octreotide	growth hormone	MESH:D015282	2688	Chemical	Gene	study|nmod|START_ENTITY effects|dep|study effects|nmod|galanin galanin|nmod|release release|amod|END_ENTITY	Inhibitory effects of galanin on growth_hormone -LRB- GH -RRB- release in cultured GH-secreting adenoma cells : comparative study with octreotide , GH-releasing hormone , and thyrotropin-releasing_hormone .
25594044	0	octreotide	11,21	hTERT	94,99	octreotide	hTERT	MESH:D015282	7015	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|amod|END_ENTITY	Effects of octreotide and insulin on colon_cancer cellular proliferation and correlation with hTERT activity .
16375990	0	octreotide	44,54	heme_oxygenase-1	14,30	octreotide	heme oxygenase-1	MESH:D015282	24451(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|induction induction|amod|END_ENTITY	The effect of heme_oxygenase-1 induction by octreotide on radiation_enteritis .
17914959	0	octreotide	40,50	heme_oxygenase-1	10,26	octreotide	heme oxygenase-1	MESH:D015282	24451(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|induction induction|amod|END_ENTITY	Effect of heme_oxygenase-1 induction by octreotide on TNBS-induced colitis .
11137181	0	octreotide	10,20	insulin	24,31	octreotide	insulin	MESH:D015282	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|requirement requirement|compound|END_ENTITY	Effect of octreotide on insulin requirement , hepatic glucose production , growth_hormone , glucagon and c-peptide levels in type 2 diabetic patients with chronic_renal_failure or normal renal function .
7642173	0	octreotide	20,30	insulin	48,55	octreotide	insulin	MESH:D015282	3630	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|resistance resistance|compound|END_ENTITY	Long-term effect of octreotide in acromegaly on insulin resistance .
11069527	0	octreotide	103,113	insulin-like_growth_factor_1	62,90	octreotide	insulin-like growth factor 1	MESH:D015282	3479	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Refractory pretibial myxoedema with response to intralesional insulin-like_growth_factor_1 antagonist -LRB- octreotide -RRB- : downregulation of hyaluronic_acid production by the lesional fibroblasts .
24331588	0	octreotide	11,21	nitric_oxide_synthase	25,46	octreotide	nitric oxide synthase	MESH:D015282	24598(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|amod|END_ENTITY	Effects of octreotide on nitric_oxide_synthase expression in the small intestine of high fat diet-induced obese rats .
21764706	0	octreotide	44,54	p53	76,79	octreotide	p53	MESH:D015282	7157	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Inhibitory effect of somatostatin analogue octreotide on the expression of p53 and Ras in human gastric_cancer -RSB- .
8428709	0	octreotide	18,28	parathyroid_hormone	32,51	octreotide	parathyroid hormone	MESH:D015282	5741	Chemical	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	Lack of effect of octreotide on parathyroid_hormone levels and urinary excretion of epidermal growth factor .
9718014	0	octreotide	8,18	parathyroid_hormone	45,64	octreotide	parathyroid hormone	MESH:D015282	5741	Chemical	Gene	Role|nmod|START_ENTITY END_ENTITY|nsubj|Role	Role of octreotide on release of intact 1-84 parathyroid_hormone from human parathyroid cells .
8778155	0	octreotide	21,31	prolactin	45,54	octreotide	prolactin	MESH:D015282	5617	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|END_ENTITY	Effect of 4 weeks of octreotide treatment on prolactin , thyroid stimulating hormone and thyroid hormones in acromegalic patients .
9302560	0	octreotide	34,44	prolactin	75,84	octreotide	prolactin	MESH:D015282	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|proliferation proliferation|compound|END_ENTITY	The effect of somatostatin analog octreotide on diethylstilbestrol-induced prolactin secretion , cell proliferation and vascular changes in the rat anterior pituitary gland .
7724472	0	octreotide	18,28	somatostatin	44,56	octreotide	somatostatin	MESH:D015282	24797(Tax:10116)	Chemical	Gene	START_ENTITY|appos|analogue analogue|compound|END_ENTITY	Hepatic uptake of octreotide , a long-acting somatostatin analogue , via a bile_acid transport system .
9042991	0	octreotide	11,21	somatostatin	25,37	octreotide	somatostatin	MESH:D015282	6750	Chemical	Gene	START_ENTITY|appos|analogue analogue|compound|END_ENTITY	Effects of octreotide , a somatostatin analogue , on gastric function evaluated by real-time ultrasonography .
11291560	0	octreotide	52,62	vascular_endothelial_growth_factor	14,48	octreotide	vascular endothelial growth factor	MESH:D015282	7422	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of vascular_endothelial_growth_factor by octreotide in colorectal_cancer patients .
18953743	0	octreotide	122,132	vascular_endothelial_growth_factor	14,48	octreotide	vascular endothelial growth factor	MESH:D015282	7422	Chemical	Gene	treatment|amod|START_ENTITY reference|nmod|treatment Expression|dep|reference Expression|nmod|END_ENTITY	Expression of vascular_endothelial_growth_factor in growth_hormone-secreting pituitary_adenomas : special reference to the octreotide treatment .
11106918	0	octreotide_acetate	14,32	LAR	33,36	octreotide acetate	LAR	MESH:D015282	5792	Chemical	Gene	Comparison|nmod|START_ENTITY END_ENTITY|nsubj|Comparison	Comparison of octreotide_acetate LAR and lanreotide SR in patients with acromegaly .
15137872	0	octyl_gallate	36,49	Lipoxygenase	0,12	octyl gallate	Lipoxygenase	MESH:C016627	547836(Tax:3847)	Chemical	Gene	activity|nmod|START_ENTITY END_ENTITY|dobj|activity	Lipoxygenase inhibitory activity of octyl_gallate .
19679048	0	octylphenol	12,23	BRCA1	45,50	octylphenol	BRCA1	MESH:C474055	497672(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Prepubertal octylphenol exposure up-regulate BRCA1 expression , down-regulate ERalpha expression and reduce rat mammary_tumorigenesis .
19140725	0	odanacatib	42,52	Cathepsin_K	63,74	odanacatib	Cathepsin K	MESH:C527128	1513	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	A practical enantioselective synthesis of odanacatib , a potent Cathepsin_K inhibitor , via triflate displacement of an alpha-trifluoromethylbenzyl_triflate .
23785020	0	oestradiol	64,74	Growth_hormone	0,14	oestradiol	Growth hormone	MESH:D004958	2688	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|activity activity|amod|END_ENTITY	Growth_hormone -LRB- GH -RRB- activity is associated with increased serum oestradiol and reduced anti-M llerian hormone in healthy male volunteers treated with GH and a GH antagonist .
16133120	0	oestradiol	21,31	IGF-1	52,57	oestradiol	IGF-1	MESH:D004958	24482(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Antagonic effects of oestradiol in interaction with IGF-1 on proliferation of lactotroph cells in vitro .
11517293	0	oestradiol	139,149	IL-8	180,184	oestradiol	IL-8	MESH:D004958	3576	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Ectopic endometrial cells express high concentrations of interleukin _ -LRB- IL -RRB- -8 in vivo regardless of the menstrual cycle phase and respond to oestradiol by up-regulating IL-1-induced IL-8 expression in vitro .
16423056	0	oestradiol	102,112	IL-8	52,56	oestradiol	IL-8	MESH:D004958	3576	Chemical	Gene	effect|nmod|START_ENTITY lack|nmod|effect regulation|dep|lack regulation|nmod|chemotaxis chemotaxis|nmod|END_ENTITY	Differential regulation of neutrophil chemotaxis to IL-8 and fMLP by GM-CSF : lack of direct effect of oestradiol .
786508	0	oestradiol	10,20	LHRH	57,61	oestradiol	LHRH	MESH:D004958	2796	Chemical	Gene	Effect|nmod|START_ENTITY induced|nsubj|Effect induced|nmod|END_ENTITY	Effect of oestradiol on gonadotrophin release induced by LHRH in men .
11732982	0	oestradiol	102,112	VEGF	50,54	oestradiol	VEGF	MESH:D004958	83785(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY Expression|dep|regulation Expression|nmod|receptors receptors|appos|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptors in rat corpus luteum : regulation by oestradiol during mid-pregnancy .
16234819	0	oestradiol	11,21	VEGF	39,43	oestradiol	VEGF	MESH:D004958	7422	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of oestradiol and tamoxifen on VEGF , soluble VEGFR-1 , and VEGFR-2 in breast_cancer and endothelial cells .
6159438	0	oestradiol	11,21	alpha_2-macroglobulin	63,84	oestradiol	alpha 2-macroglobulin	MESH:D004958	24153(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|concentration concentration|nmod|END_ENTITY	Effects of oestradiol and progesterone on the concentration of alpha_2-macroglobulin in the sera of injured male and female rats .
11882013	0	oestradiol	49,59	bone_morphogenetic_protein_2	10,38	oestradiol	bone morphogenetic protein 2	MESH:D004958	443173(Tax:9940)	Chemical	Gene	production|compound|START_ENTITY Effect|nmod|production Effect|nmod|END_ENTITY	Effect of bone_morphogenetic_protein_2 -LRB- BMP2 -RRB- on oestradiol and inhibin_A production by sheep granulosa cells , and localization of BMP receptors in the ovary by immunohistochemistry .
2121397	0	oestradiol	14,24	epidermal_growth_factor	39,62	oestradiol	epidermal growth factor	MESH:D004958	1950	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Inhibition of oestradiol production by epidermal_growth_factor in human granulosa cells of normal and polycystic_ovaries .
3486035	0	oestradiol	115,125	epidermal_growth_factor	14,37	oestradiol	epidermal growth factor	MESH:D004958	1950	Chemical	Gene	17_beta_hydroxysteroid_dehydrogenase|amod|START_ENTITY activity|nmod|17_beta_hydroxysteroid_dehydrogenase transforming|nmod|activity transforming|nsubj|effect effect|nmod|END_ENTITY	The effect of epidermal_growth_factor , transforming growth factor and breast_tumour homogenates on the activity of oestradiol 17_beta_hydroxysteroid_dehydrogenase in cultured adipose tissue .
7561643	0	oestradiol	96,106	epidermal_growth_factor	52,75	oestradiol	epidermal growth factor	MESH:D004958	105614258	Chemical	Gene	secretion|nmod|START_ENTITY END_ENTITY|nmod|secretion	The in vivo effects of fibroblast growth factor and epidermal_growth_factor on the secretion of oestradiol , androstenedione and progesterone by the autotransplanted ovary in the ewe .
22612621	0	oestradiol	91,101	gonadotrophin-releasing_hormone	33,64	oestradiol	gonadotrophin-releasing hormone	MESH:D004958	14714(Tax:10090)	Chemical	Gene	modulation|nmod|START_ENTITY modulation|nmod|activity activity|amod|END_ENTITY	Activity-dependent modulation of gonadotrophin-releasing_hormone neurone activity by acute oestradiol .
2120380	0	oestradiol	49,59	growth_hormone	31,45	oestradiol	growth hormone	MESH:D004958	2688	Chemical	Gene	production|amod|START_ENTITY effect|nmod|production effect|nmod|END_ENTITY	Direct gonadotrophic effect of growth_hormone on oestradiol production by human granulosa cells in vitro .
9306984	0	oestradiol	55,65	growth_hormone	13,27	oestradiol	growth hormone	MESH:D004958	81668(Tax:10116)	Chemical	Gene	Influence|acl|START_ENTITY Influence|nmod|END_ENTITY	Influence of growth_hormone on the uterine response to oestradiol in rats .
12580757	0	oestradiol	28,38	nerve_growth_factor-alpha	68,93	oestradiol	nerve growth factor-alpha	MESH:D004958	18048(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|amod|END_ENTITY	Comparison of the effect of oestradiol , tamoxifen and raloxifene on nerve_growth_factor-alpha expression in specific neonatal mouse uterine cell types using laser capture microdissection .
12834435	0	oestradiol	21,31	neurokinin_B	35,47	oestradiol	neurokinin B	MESH:D004958	443213(Tax:9940)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|amod|END_ENTITY	Short-term effect of oestradiol on neurokinin_B mRNA expression in the infundibular nucleus of ewes .
2212928	0	oestradiol	38,48	oxytocin	72,80	oestradiol	oxytocin	MESH:D004958	5020	Chemical	Gene	infusion|compound|START_ENTITY infusion|nmod|concentrations concentrations|compound|END_ENTITY	Influence of mating and intra-uterine oestradiol infusion on peripheral oxytocin concentrations in the sow .
9623487	0	oestradiol	10,20	oxytocin	32,40	oestradiol	oxytocin	MESH:D004958	5020	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Effect of oestradiol on ovarian oxytocin secretion rate and luteolysis in the ewe after ovarian auto-transplantation .
7172459	0	oestradiol	31,41	prl	108,111	oestradiol	prl	MESH:D004958	5617	Chemical	Gene	lowers|dobj|START_ENTITY lowers|parataxis|evidence evidence|nmod|role role|nmod|oestradiol oestradiol|nmod|secretion secretion|compound|END_ENTITY	Hydrotestolactone lowers serum oestradiol and PRL levels in normal men : evidence of a role of oestradiol in prl secretion .
7172459	0	oestradiol	94,104	prl	108,111	oestradiol	prl	MESH:D004958	5617	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Hydrotestolactone lowers serum oestradiol and PRL levels in normal men : evidence of a role of oestradiol in prl secretion .
18208546	0	oestradiol	11,21	progesterone_receptor	32,53	oestradiol	progesterone receptor	MESH:D004958	25154(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Endogenous oestradiol regulates progesterone_receptor expression in the brain of female rat fetuses : what is the source of oestradiol ?
2615350	0	oestradiol	44,54	progesterone_receptor	14,35	oestradiol	progesterone receptor	MESH:D004958	5241	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|mRNA mRNA|compound|END_ENTITY	Regulation of progesterone_receptor mRNA by oestradiol and antioestrogens in breast_cancer cell lines .
2717543	0	oestradiol	122,132	prolactin	22,31	oestradiol	prolactin	MESH:D004958	5617	Chemical	Gene	secretion|amod|START_ENTITY effect|nmod|secretion effect|dep|effect effect|nmod|END_ENTITY	Stimulatory effect of prolactin on human placental progesterone secretion at term in vitro : possible inhibitory effect on oestradiol secretion .
3087134	0	oestradiol	40,50	prolactin	59,68	oestradiol	prolactin	MESH:D004958	24683(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY secretion|compound|END_ENTITY	The effect of oestriol and tamoxifen on oestradiol induced prolactin secretion in anaesthetised rats .
3716758	0	oestradiol	11,21	prolactin	70,79	oestradiol	prolactin	MESH:D004958	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|nmod|END_ENTITY	Effects of oestradiol and progesterone on stress-induced secretion of prolactin in ovariectomized and/or adrenalectomized female rats .
6424977	0	oestradiol	68,78	prolactin	28,37	oestradiol	prolactin	MESH:D004958	5617	Chemical	Gene	START_ENTITY|nsubj|Changes Changes|nmod|levels levels|nmod|END_ENTITY	Changes in plasma levels of prolactin , in relation to those of FSH , oestradiol , androstenedione and progesterone around the preovulatory surge of LH in women .
6436427	0	oestradiol	38,48	prolactin	15,24	oestradiol	prolactin	MESH:D004958	24683(Tax:10116)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Stimulation of prolactin secretion by oestradiol in the rat is associated with increased hypothalamic release of thyrotrophin-releasing_hormone .
6655402	0	oestradiol	77,87	prolactin	14,23	oestradiol	prolactin	MESH:D004958	24683(Tax:10116)	Chemical	Gene	affect|nmod|START_ENTITY affect|nsubj|Evidence Evidence|dep|END_ENTITY	Evidence that prolactin does not affect the induction of sexual behaviour by oestradiol and progesterone in ovariectomized rats .
6747503	0	oestradiol	35,45	prolactin	11,20	oestradiol	prolactin	MESH:D004958	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of prolactin on follicular oestradiol production in the rat .
3305759	0	oestradiol	35,45	renin	65,70	oestradiol	renin	MESH:D004958	24715(Tax:10116)	Chemical	Gene	activity|dep|START_ENTITY activity|compound|END_ENTITY	Hormone profiles for progesterone , oestradiol , prolactin , plasma renin activity , aldosterone and corticosterone during pregnancy and pseudopregnancy in two strains of rat : correlation with renal studies .
6681600	0	oestradiol	156,166	sex_hormone_binding_globulin	170,198	oestradiol	sex hormone binding globulin	MESH:D004958	6462	Chemical	Gene	non-specific|nmod|START_ENTITY evidence|nmod|non-specific albumin|dep|evidence Binding|nmod|albumin Binding|acl|END_ENTITY	Binding of testosterone and oestradiol to sex_hormone_binding_globulin , human serum albumin and other plasma proteins : evidence for non-specific binding of oestradiol to sex_hormone_binding_globulin .
6681600	0	oestradiol	156,166	sex_hormone_binding_globulin	42,70	oestradiol	sex hormone binding globulin	MESH:D004958	6462	Chemical	Gene	non-specific|nmod|START_ENTITY evidence|nmod|non-specific albumin|dep|evidence albumin|amod|END_ENTITY	Binding of testosterone and oestradiol to sex_hormone_binding_globulin , human serum albumin and other plasma proteins : evidence for non-specific binding of oestradiol to sex_hormone_binding_globulin .
6814138	0	oestradiol	11,21	sex_hormone_binding_globulin	25,53	oestradiol	sex hormone binding globulin	MESH:D004958	6462	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of oestradiol on sex_hormone_binding_globulin .
427059	0	oestriol	41,49	aminopeptidase	62,76	oestriol	aminopeptidase	CHEBI:27974	10404	Chemical	Gene	concentrations|amod|START_ENTITY concentrations|amod|END_ENTITY	The relation between plasma unconjugated oestriol and cystine aminopeptidase concentrations and uterine contractions .
3087134	0	oestriol	14,22	prolactin	59,68	oestriol	prolactin	CHEBI:27974	24683(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|compound|END_ENTITY	The effect of oestriol and tamoxifen on oestradiol induced prolactin secretion in anaesthetised rats .
16805920	0	oestrogen	11,20	AT1	123,126	oestrogen	AT1	CHEBI:50114	185	Chemical	Gene	signalling|compound|START_ENTITY signalling|dep|role role|nmod|END_ENTITY	Nongenomic oestrogen signalling in oestrogen receptor negative breast_cancer cells : a role for the angiotensin II receptor AT1 .
11825917	0	oestrogen	84,93	Androgen_receptor	0,17	oestrogen	Androgen receptor	CHEBI:50114	367	Chemical	Gene	receptors|compound|START_ENTITY relation|nmod|receptors expression|dep|relation expression|amod|END_ENTITY	Androgen_receptor expression in ductal_carcinoma in situ of the breast : relation to oestrogen and progesterone receptors .
26742006	0	oestrogen	71,80	Androgen_receptor	0,17	oestrogen	Androgen receptor	CHEBI:50114	367	Chemical	Gene	breast_cancer|amod|START_ENTITY response|nmod|breast_cancer predicts|dobj|response predicts|nsubj|expression expression|amod|END_ENTITY	Androgen_receptor expression predicts beneficial tamoxifen response in oestrogen receptor-a-negative breast_cancer .
4007019	0	oestrogen	76,85	Androgen_receptor	0,17	oestrogen	Androgen receptor	CHEBI:50114	367	Chemical	Gene	activity|compound|START_ENTITY activity|nmod|activity activity|amod|END_ENTITY	Androgen_receptor activity in human breast_cancer and its relationship with oestrogen and progestogen receptor activity .
7981903	0	oestrogen	131,140	BCL-2	18,23	oestrogen	BCL-2	CHEBI:50114	596	Chemical	Gene	correlates|xcomp|START_ENTITY correlates|nsubj|prevalence prevalence|nmod|immunoreactivity immunoreactivity|compound|END_ENTITY	The prevalence of BCL-2 immunoreactivity in breast_carcinomas and its clinicopathological correlates , with particular reference to oestrogen receptor status .
7833141	0	oestrogen	44,53	Bcl-2	14,19	oestrogen	Bcl-2	CHEBI:50114	596	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Modulation of Bcl-2 and Ki-67 expression in oestrogen receptor-positive human breast_cancer by tamoxifen .
12362231	0	oestrogen	32,41	C-reactive_protein	65,83	oestrogen	C-reactive protein	CHEBI:50114	1401	Chemical	Gene	therapy|compound|START_ENTITY therapy|nmod|levels levels|amod|END_ENTITY	Effects of transdermal and oral oestrogen replacement therapy on C-reactive_protein levels in postmenopausal women : a randomised , placebo-controlled trial .
15089836	0	oestrogen	11,20	C-reactive_protein	50,68	oestrogen	C-reactive protein	CHEBI:50114	1401	Chemical	Gene	therapy|compound|START_ENTITY therapy|nmod|levels levels|amod|END_ENTITY	Effects of oestrogen replacement therapy on serum C-reactive_protein levels in hysterectomised women .
1854619	0	oestrogen	94,103	Cathepsin_D	0,11	oestrogen	Cathepsin D	CHEBI:50114	1509	Chemical	Gene	factor|amod|START_ENTITY features|nmod|factor correlation|nmod|features assay|dep|correlation assay|amod|END_ENTITY	Cathepsin_D assay in ovarian_cancer : correlation with pathological features and receptors for oestrogen , progesterone and epidermal growth factor .
24825143	0	oestrogen	134,143	DNMT1	182,187	oestrogen	DNMT1	CHEBI:50114	1786	Chemical	Gene	downregulation|amod|START_ENTITY downregulation|nmod|END_ENTITY	17b-oestradiol enhances global DNA hypomethylation in CD4-positive T cells from female patients with lupus , through overexpression of oestrogen receptor-a-mediated downregulation of DNMT1 .
15693887	0	oestrogen	14,23	E-cadherin	45,55	oestrogen	E-cadherin	CHEBI:50114	999	Chemical	Gene	receptor|compound|START_ENTITY receptor|nmod|END_ENTITY	Expression of oestrogen receptor and loss of E-cadherin are diagnostic for gastric metastasis of breast_carcinoma .
10381820	2	oestrogen	306,315	ER-beta	331,338	oestrogen	ER-beta	CHEBI:50114	2100	Chemical	Gene	isoform|amod|START_ENTITY isoform|appos|END_ENTITY	With the recent discovery of the oestrogen receptor-beta -LRB- ER-beta -RRB- isoform , the aim of this study was to investigate whether differences in the expression of ER-alpha and ER-beta might explain this observation .
12398995	0	oestrogen	6,15	ER_alpha	54,62	oestrogen	ER alpha	CHEBI:50114	2099	Chemical	Gene	receptors|compound|START_ENTITY receptors|dep|expression expression|nmod|END_ENTITY	Human oestrogen receptors : differential expression of ER_alpha and beta and the identification of ER_beta variants .
12535323	0	oestrogen	31,40	ER_alpha	57,65	oestrogen	ER alpha	CHEBI:50114	2099	Chemical	Gene	alpha|amod|START_ENTITY alpha|appos|END_ENTITY	Immunohistochemical studies on oestrogen receptor alpha -LRB- ER_alpha -RRB- and the proliferative marker Ki-67 in the sow uterus at different stages of the oestrous cycle .
14731994	0	oestrogen	4,13	ER_alpha	25,33	oestrogen	ER alpha	CHEBI:50114	2099	Chemical	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	The oestrogen receptors -LRB- ER_alpha and ER_beta -RRB- and their role in breast_cancer : a review .
9379111	0	oestrogen	14,23	ER_beta	39,46	oestrogen	ER beta	CHEBI:50114	25149(Tax:10116)	Chemical	Gene	beta|compound|START_ENTITY beta|appos|END_ENTITY	Expression of oestrogen receptor beta -LRB- ER_beta -RRB- in multiple rat tissues visualised by immunohistochemistry .
9582517	0	oestrogen	14,23	ER_beta	39,46	oestrogen	ER beta	CHEBI:50114	25149(Tax:10116)	Chemical	Gene	beta|compound|START_ENTITY beta|appos|END_ENTITY	Expression of oestrogen receptor beta -LRB- ER_beta -RRB- occurs in multiple cell types , including some germ cells , in the rat testis .
15367271	0	oestrogen	31,40	ERalpha	57,64	oestrogen	ERalpha	CHEBI:50114	2099	Chemical	Gene	alpha|amod|START_ENTITY alpha|appos|END_ENTITY	Immunohistochemical studies on oestrogen receptor alpha -LRB- ERalpha -RRB- and the proliferative marker Ki-67 in the sow uterus at oestrus and early pregnancy .
17911007	0	oestrogen	27,36	ERalpha	53,60	oestrogen	ERalpha	CHEBI:50114	2099	Chemical	Gene	alpha|amod|START_ENTITY alpha|appos|END_ENTITY	Prognostic significance of oestrogen receptor alpha -LRB- ERalpha -RRB- and beta -LRB- ERbeta -RRB- , progesterone_receptor_A -LRB- PR-A -RRB- _ and_B -LRB- PR-B -RRB- in endometrial_carcinomas .
17911007	0	oestrogen	27,36	ERbeta	72,78	oestrogen	ERbeta	CHEBI:50114	2100	Chemical	Gene	alpha|amod|START_ENTITY alpha|appos|END_ENTITY	Prognostic significance of oestrogen receptor alpha -LRB- ERalpha -RRB- and beta -LRB- ERbeta -RRB- , progesterone_receptor_A -LRB- PR-A -RRB- _ and_B -LRB- PR-B -RRB- in endometrial_carcinomas .
15149721	0	oestrogen	64,73	ESR1	95,99	oestrogen	ESR1	CHEBI:50114	2099	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	About GATA3 , HNF3A , and XBP1 , three genes co-expressed with the oestrogen receptor-alpha gene -LRB- ESR1 -RRB- in breast_cancer .
16978173	0	oestrogen	86,95	ESR1	108,112	oestrogen	ESR1	CHEBI:50114	397435(Tax:9823)	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Comparison of genetic models for analysing the effects of a PvuII polymorphism in the oestrogen receptor 1 -LRB- ESR1 -RRB- gene on prolificacy in an Iberian x Meishan pig population .
19673915	0	oestrogen	12,21	ESR1	32,36	oestrogen	ESR1	CHEBI:50114	2099	Chemical	Gene	receptor|compound|START_ENTITY receptor|dep|PvuII PvuII|compound|END_ENTITY	Role of the oestrogen receptor -LRB- ESR1 PvuII and ESR1 325_C - > G -RRB- and progesterone_receptor -LRB- PROGINS -RRB- polymorphisms in genetic susceptibility to migraine in a North Indian population .
20028801	0	oestrogen	16,25	ESR1	36,40	oestrogen	ESR1	CHEBI:50114	2099	Chemical	Gene	Ontogeny|nmod|START_ENTITY receptors|nsubj|Ontogeny receptors|dobj|END_ENTITY	Ontogeny of the oestrogen receptors ESR1 and ESR2 during gonadal development in the tammar wallaby , Macropus eugenii .
23279460	0	oestrogen	62,71	ESR1	88,92	oestrogen	ESR1	CHEBI:50114	552888(Tax:9685)	Chemical	Gene	alpha|amod|START_ENTITY alpha|appos|END_ENTITY	Feline gonads exhibit tissue specific alternative splicing of oestrogen receptor alpha -LRB- ESR1 -RRB- .
15996129	0	oestrogen	30,39	ESR2	55,59	oestrogen	ESR2	CHEBI:50114	281146(Tax:9913)	Chemical	Gene	beta|compound|START_ENTITY beta|appos|END_ENTITY	Cell-specific localization of oestrogen receptor beta -LRB- ESR2 -RRB- mRNA within various bovine ovarian cell types using in situ hybridization .
17941906	0	oestrogen	20,29	ESR2	50,54	oestrogen	ESR2	CHEBI:50114	2100	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphism of the oestrogen receptor beta gene -LRB- ESR2 -RRB- is associated with susceptibility to Graves ' _ disease .
21645039	0	oestrogen	27,36	G-protein-coupled_receptor_30	86,115	oestrogen	G-protein-coupled receptor 30	CHEBI:50114	2852	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|receptor receptor|compound|END_ENTITY	Neuroprotective effects of oestrogen against oxidative toxicity through activation of G-protein-coupled_receptor_30 receptor .
3380016	0	oestrogen	81,90	Growth_hormone	0,14	oestrogen	Growth hormone	CHEBI:50114	2688	Chemical	Gene	therapy|nmod|START_ENTITY END_ENTITY|nmod|therapy	Growth_hormone and somatomedin_C during post-menopausal replacement therapy with oestrogen alone and in combination with an antioestrogen .
20664587	0	oestrogen	38,47	HER2	23,27	oestrogen	HER2	CHEBI:50114	2064	Chemical	Gene	receptor|amod|START_ENTITY receptor|nummod|END_ENTITY	Increased mortality in HER2 positive , oestrogen receptor positive invasive breast_cancer : a population-based study .
17492948	0	oestrogen	24,33	IGF-1	52,57	oestrogen	IGF-1	CHEBI:50114	3479	Chemical	Gene	administration|compound|START_ENTITY administration|nmod|END_ENTITY	Effects of the route of oestrogen administration on IGF-1 and IGFBP-3 in healthy postmenopausal women : results from a randomized placebo-controlled study .
791539	0	oestrogen	94,103	LHRH	151,155	oestrogen	LHRH	CHEBI:50114	2796	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|response response|nmod|END_ENTITY	The control of gonadotrophin release in women with hyperprolactinaemic amenorrhoea : effect of oestrogen and progesterone on the LH and FSH response to LHRH .
658265	0	oestrogen	11,20	N-acetyl_transferase	52,72	oestrogen	N-acetyl transferase	CHEBI:50114	116631(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|amod|END_ENTITY	Effects of oestrogen and progesterone on rat pineal N-acetyl_transferase activity and melatonin production .
1752938	0	oestrogen	8,17	P29	0,3	oestrogen	P29	CHEBI:50114	25949	Chemical	Gene	protein|amod|START_ENTITY END_ENTITY|appos|protein	P29 , an oestrogen receptor-associated protein , is down-regulated by mifepristone in first trimester human placenta and decidua .
401551	0	oestrogen	73,82	TRH	62,65	oestrogen	TRH	CHEBI:50114	7200	Chemical	Gene	treatment|compound|START_ENTITY END_ENTITY|nmod|treatment	Serum thyrotrophin , prolactin and growth_hormone , response to TRH during oestrogen treatment .
10690175	0	oestrogen	126,135	androgen_receptor	36,53	oestrogen	androgen receptor	CHEBI:50114	367	Chemical	Gene	receptors|compound|START_ENTITY relation|nmod|receptors localisation|dep|relation localisation|nmod|END_ENTITY	Immunohistochemical localisation of androgen_receptor in apocrine metaplasia and apocrine adenosis of the breast : relation to oestrogen and progesterone receptors .
11958468	0	oestrogen	102,111	androgen_receptor	60,77	oestrogen	androgen receptor	CHEBI:50114	280675(Tax:9913)	Chemical	Gene	receptor|compound|START_ENTITY Effects|appos|receptor Effects|nmod|progestagens progestagens|nmod|expression expression|nmod|END_ENTITY	Effects of synthetic progestagens on the mRNA expression of androgen_receptor , progesterone receptor , oestrogen receptor alpha and beta , insulin-like growth factor-1 -LRB- IGF-1 -RRB- and IGF-1 receptor in heifer tissues .
20500749	0	oestrogen	18,27	androgen_receptor	46,63	oestrogen	androgen receptor	CHEBI:50114	24208(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY administration|nmod|expression expression|compound|END_ENTITY	Effect of chronic oestrogen administration on androgen_receptor expression in reproductive organs and pituitary of adult male rat .
7530286	0	oestrogen	101,110	androgen_receptor	129,146	oestrogen	androgen receptor	CHEBI:50114	367	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Androgen and oestrogen responsiveness of stromal cells derived from the human hyperplastic prostate : oestrogen regulation of the androgen_receptor .
14757857	0	oestrogen	57,66	apolipoprotein_E	26,42	oestrogen	apolipoprotein E	CHEBI:50114	348	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	The allelic modulation of apolipoprotein_E expression by oestrogen : potential relevance for Alzheimer 's _ disease .
18192335	0	oestrogen	109,118	apolipoprotein_E	92,108	oestrogen	apolipoprotein E	CHEBI:50114	11816(Tax:10090)	Chemical	Gene	mice|compound|START_ENTITY mice|amod|END_ENTITY	Tissue-specific regulation of ACE/ACE2 and AT1/AT2 _ receptor gene expression by oestrogen in apolipoprotein_E / oestrogen receptor-alpha knock-out mice .
18192335	0	oestrogen	79,88	apolipoprotein_E	92,108	oestrogen	apolipoprotein E	CHEBI:50114	11816(Tax:10090)	Chemical	Gene	_|nmod|START_ENTITY _|nmod|mice mice|amod|END_ENTITY	Tissue-specific regulation of ACE/ACE2 and AT1/AT2 _ receptor gene expression by oestrogen in apolipoprotein_E / oestrogen receptor-alpha knock-out mice .
12392497	0	oestrogen	11,20	caspase-3	37,46	oestrogen	caspase-3	CHEBI:50114	12367(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|amod|END_ENTITY	Effects of oestrogen and exercise on caspase-3 activity in primary and secondary lymphoid compartments in ovariectomized mice .
11957260	0	oestrogen	14,23	cathepsin_D	83,94	oestrogen	cathepsin D	CHEBI:50114	1509	Chemical	Gene	p53|compound|START_ENTITY Expression|nmod|p53 Expression|acl|END_ENTITY	Expression of oestrogen and progesterone_receptors , Ki-67 , p53 and BCL-2 proteins , cathepsin_D , urokinase plasminogen activator and urokinase plasminogen activator-receptors in carcinomas of the female breast in an African population .
1832905	0	oestrogen	43,52	cathepsin_D	24,35	oestrogen	cathepsin D	CHEBI:50114	1509	Chemical	Gene	receptors|compound|START_ENTITY relevance|nmod|receptors relevance|nmod|END_ENTITY	Prognostic relevance of cathepsin_D versus oestrogen receptors in node negative breast_cancers .
3588310	0	oestrogen	47,56	cathepsin_D	20,31	oestrogen	cathepsin D	CHEBI:50114	1509	Chemical	Gene	responsive|amod|START_ENTITY cells|amod|responsive levels|nmod|cells levels|amod|END_ENTITY	Oestrogen regulates cathepsin_D mRNA levels in oestrogen responsive human breast_cancer cells .
8847064	0	oestrogen	31,40	cathepsin_D	18,29	oestrogen	cathepsin D	CHEBI:50114	1509	Chemical	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	The expression of cathepsin_D , oestrogen receptor and progestogen receptor in hydatidiform mole -- an immunohistochemical study .
11566608	0	oestrogen	71,80	epidermal_growth_factor_receptor	14,46	oestrogen	epidermal growth factor receptor	CHEBI:50114	1956	Chemical	Gene	breast_cancer|amod|START_ENTITY Modulation|nmod|breast_cancer Modulation|nmod|END_ENTITY	Modulation of epidermal_growth_factor_receptor in endocrine-resistant , oestrogen receptor-positive breast_cancer .
3292735	0	oestrogen	22,31	epidermal_growth_factor_receptor	41,73	oestrogen	epidermal growth factor receptor	CHEBI:50114	1956	Chemical	Gene	ER-D5|amod|START_ENTITY ER-D5|dep|END_ENTITY	Relationships between oestrogen receptor , epidermal_growth_factor_receptor , ER-D5 , and P24 oestrogen regulated protein in human breast_cancer .
8814683	0	oestrogen	66,75	epidermal_growth_factor_receptor	86,118	oestrogen	epidermal growth factor receptor	CHEBI:50114	1956	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Short-term effects of pure anti-oestrogen ICI_182780 treatment on oestrogen receptor , epidermal_growth_factor_receptor and transforming_growth_factor-alpha protein expression in human breast_cancer .
18835735	0	oestrogen	16,25	growth_hormone	50,64	oestrogen	growth hormone	CHEBI:50114	2688	Chemical	Gene	therapy|compound|START_ENTITY therapy|acl:relcl|dissociates dissociates|dobj|END_ENTITY	Short-term oral oestrogen therapy dissociates the growth_hormone / insulin-like growth factor-I axis without altering energy metabolism in premenopausal women .
3661068	0	oestrogen	11,20	growth_hormone	31,45	oestrogen	growth hormone	CHEBI:50114	2688	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of oestrogen and human growth_hormone on pregnancy-associated plasma proteins in the rat .
6794555	0	oestrogen	199,208	growth_hormone	38,52	oestrogen	growth hormone	CHEBI:50114	81668(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|nmod|END_ENTITY	Effects on the secretion of pituitary growth_hormone , thyroid stimulating hormone , luteinizing hormone and follicle stimulating hormone in rats rendered hyperprolactinaemic by chronic treatment with oestrogen .
7931002	0	oestrogen	31,40	growth_hormone	87,101	oestrogen	growth hormone	CHEBI:50114	81668(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY regulation|nmod|receptor regulation|dep|interplay interplay|nmod|END_ENTITY	The hormonal regulation of the oestrogen receptor in rat liver : an interplay involving growth_hormone , thyroid hormones and glucocorticoids .
11860375	0	oestrogen	23,32	myeloperoxidase	65,80	oestrogen	myeloperoxidase	CHEBI:50114	303413(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Differential effect of oestrogen on post-exercise cardiac_muscle myeloperoxidase and calpain activities in female rats .
12899712	3	oestrogen	438,447	p73	483,486	oestrogen	p16	CHEBI:50114	1029	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	In this study , methylation-specific polymerase chain reaction -LRB- MSP -RRB- was used to define the methylation status of a panel of nine genes , comprising p15 , p16 , RARbeta , oestrogen receptor -LRB- ER -RRB- , E-cadherin -LRB- E-CAD -RRB- , p73 , caspase_8 -LRB- CASP8 -RRB- , VHL and MGMT , in 29 patients with APL .
10844586	0	oestrogen	195,204	progesterone_receptor	134,155	oestrogen	progesterone receptor	CHEBI:50114	443444(Tax:9940)	Chemical	Gene	hypothalamus|nmod|START_ENTITY mRNA|nmod|hypothalamus mRNA|compound|END_ENTITY	The distribution of progesterone_receptor immunoreactivity and mRNA in the preoptic area and hypothalamus of the ewe : upregulation of progesterone_receptor mRNA in the mediobasal hypothalamus by oestrogen .
10844586	0	oestrogen	195,204	progesterone_receptor	20,41	oestrogen	progesterone receptor	CHEBI:50114	443444(Tax:9940)	Chemical	Gene	hypothalamus|nmod|START_ENTITY mRNA|nmod|hypothalamus upregulation|nmod|mRNA distribution|dep|upregulation distribution|nmod|immunoreactivity immunoreactivity|compound|END_ENTITY	The distribution of progesterone_receptor immunoreactivity and mRNA in the preoptic area and hypothalamus of the ewe : upregulation of progesterone_receptor mRNA in the mediobasal hypothalamus by oestrogen .
11026564	0	oestrogen	124,133	progesterone_receptor	13,34	oestrogen	progesterone receptor	CHEBI:50114	25154(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY immunoexpression|nmod|treatment immunoexpression|nsubj|Induction Induction|nmod|END_ENTITY	Induction of progesterone_receptor immunoexpression in stromal tissue throughout the male reproductive tract after neonatal oestrogen treatment of rats .
17400808	0	oestrogen	25,34	progesterone_receptor	68,89	oestrogen	progesterone receptor	CHEBI:50114	25154(Tax:10116)	Chemical	Gene	isoforms|amod|START_ENTITY isoforms|nmod|END_ENTITY	The integrated action of oestrogen receptor isoforms and sites with progesterone_receptor in the gonadotrope modulates LH secretion : evidence from tamoxifen-treated ovariectomized rats .
19432961	0	oestrogen	28,37	progesterone_receptor	48,69	oestrogen	progesterone receptor	CHEBI:50114	5241	Chemical	Gene	status|amod|START_ENTITY status|compound|END_ENTITY	MicroRNA signatures predict oestrogen receptor , progesterone_receptor and HER2/neu receptor status in breast_cancer .
21375607	0	oestrogen	20,29	progesterone_receptor	40,61	oestrogen	progesterone receptor	CHEBI:50114	5241	Chemical	Gene	receptor|compound|START_ENTITY blocks|nmod|receptor blocks|nsubj|END_ENTITY	Immunochemistry for oestrogen receptor , progesterone_receptor and HER2 on cell blocks in primary breast_carcinoma .
2139575	0	oestrogen	120,129	progesterone_receptor	5,26	oestrogen	progesterone receptor	CHEBI:50114	5241	Chemical	Gene	conditions|amod|START_ENTITY adapted|nmod|conditions adapted|nsubj|concentration concentration|compound|END_ENTITY	High progesterone_receptor concentration in a variant of the ZR-75-1 human breast_cancer cell line adapted to growth in oestrogen free conditions .
23936949	0	oestrogen	76,85	progesterone_receptor	96,117	oestrogen	progesterone receptor	CHEBI:50114	5241	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Prevalence of known prognostic factors in female breast_carcinoma including oestrogen receptor , progesterone_receptor and Her-2 / neu status -- a study in a tertiary care centre .
24269135	0	oestrogen	19,28	progesterone_receptor	39,60	oestrogen	progesterone receptor	CHEBI:50114	5241	Chemical	Gene	epidermal_growth_factor_receptor_2|amod|START_ENTITY epidermal_growth_factor_receptor_2|compound|END_ENTITY	A meta-analysis of oestrogen receptor , progesterone_receptor and human epidermal_growth_factor_receptor_2 discordance between primary breast_cancer and metastases .
25938238	0	oestrogen	37,46	progesterone_receptor	168,189	oestrogen	progesterone receptor	CHEBI:50114	5241	Chemical	Gene	breast_cancer|compound|START_ENTITY breast_cancer|nmod|definition definition|nmod|status status|compound|END_ENTITY	Clinicopathologic characteristics of oestrogen receptor-positive/progesterone _ receptor-negative/her2-negative breast_cancer according to a novel definition of negative progesterone_receptor status : a large population-based study from china .
474275	0	oestrogen	86,95	progesterone_receptor	47,68	oestrogen	progesterone receptor	CHEBI:50114	25154(Tax:10116)	Chemical	Gene	synthesis|nmod|START_ENTITY synthesis|compound|END_ENTITY	Inhibition of cell division and stimulation of progesterone_receptor synthesis in rat oestrogen target tissues by non-steroidal antioestrogens .
9835356	0	oestrogen	104,113	progesterone_receptor	14,35	oestrogen	progesterone receptor	CHEBI:50114	5241	Chemical	Gene	correlation|nmod|START_ENTITY Expression|dep|correlation Expression|nmod|isoforms isoforms|compound|END_ENTITY	Expression of progesterone_receptor isoforms in corpora lutea of human subjects : correlation with serum oestrogen and progesterone concentrations .
989226	0	oestrogen	22,31	prolactin	47,56	oestrogen	prolactin	CHEBI:50114	5617	Chemical	Gene	START_ENTITY|advcl|circulating circulating|dobj|END_ENTITY	Influence of low dose oestrogen on circulating prolactin .
12815179	0	oestrogen	29,38	tissue-type_plasminogen_activator	54,87	oestrogen	tissue-type plasminogen activator	CHEBI:50114	5327	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|release release|amod|END_ENTITY	Acute and chronic effects of oestrogen on endothelial tissue-type_plasminogen_activator release in postmenopausal women .
10823131	0	oestrogen	47,56	transforming_growth_factor_beta_2	10,43	oestrogen	transforming growth factor beta 2	CHEBI:50114	7042	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	Effect of transforming_growth_factor_beta_2 on oestrogen metabolism in the MCF-7 breast_cancer cell line .
2009219	0	oestrogen	60,69	vitellogenin	102,114	oestrogen	vitellogenin	CHEBI:50114	424533(Tax:9031)	Chemical	Gene	element|compound|START_ENTITY element|nmod|gene gene|compound|END_ENTITY	In vivo and in vitro protein-DNA interactions at the distal oestrogen response element of the chicken vitellogenin gene : evidence for the same protein binding to this sequence in hen and rooster liver .
15761236	5	oestrogen	971,980	women	996,1001	oestrogen	IGF-I	CHEBI:50114	3479	Chemical	Gene	replacement|compound|START_ENTITY replacement|nmod|END_ENTITY	Administration of oral oestrogen in healthy post-menopausal women suppresses hepatic IGF-I production and increases pituitary GH release , and oral oestrogen replacement in women with GH_deficiency lowers IGF-I concentrations and increases the amount of GH necessary to obtain IGF-I target levels during treatment .
6555126	0	oestrogens	86,96	C18	108,111	oestrogens	C18	CHEBI:50114	27241	Chemical	Gene	START_ENTITY|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Determination of total oestrogens in pregnancy urine : rapid and simple extraction of oestrogens by Sep-Pak C18 cartridges -RSB- .
15842231	0	oestrogens	55,65	oxytocin	34,42	oestrogens	oxytocin	CHEBI:50114	5020	Chemical	Gene	promoter|nmod|START_ENTITY promoter|compound|END_ENTITY	Transcriptional activation of the oxytocin promoter by oestrogens uses a novel non-classical mechanism of oestrogen receptor action .
825328	0	oestrogens	11,21	prolactin	25,34	oestrogens	prolactin	CHEBI:50114	5617	Chemical	Gene	START_ENTITY|nmod|responses responses|compound|END_ENTITY	Effects of oestrogens on prolactin and thyrotrophin responses to TRH in women during the menstrual cycle and under oral contraceptive treatment .
8887989	0	of_pindolol	7,18	5-HT1A	60,66	of pindolol	5-HT1A	null	24473(Tax:10116)	Chemical	Gene	START_ENTITY|dep|receptors receptors|nummod|END_ENTITY	Effect of_pindolol on the function of pre - and postsynaptic 5-HT1A receptors : in vivo microdialysis and electrophysiological studies in the rat brain .
11372446	0	ofloxacin	32,41	albumin	59,66	ofloxacin	albumin	MESH:D015242	213	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- The reaction mechanism between ofloxacin and bovine serum albumin -RSB- .
12570057	0	okadaic_acid	74,86	Egr-1	15,20	okadaic acid	Egr-1	MESH:D019319	1958	Chemical	Gene	Suppression|nmod|START_ENTITY Suppression|nmod|expression expression|compound|END_ENTITY	Suppression of Egr-1 expression in human oral_squamous_carcinoma cells by okadaic_acid .
7684929	0	okadaic_acid	10,22	apo_B	26,31	okadaic acid	apo B	MESH:D019319	338	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Effect of okadaic_acid on apo_B and apo_A-I secretion by CaCo-2 cells .
8381016	0	okadaic_acid	98,110	early_growth_response_1	34,57	okadaic acid	early growth response 1	MESH:D019319	1958	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|gene gene|amod|END_ENTITY	Transcriptional regulation of the early_growth_response_1 gene in human myeloid_leukemia cells by okadaic_acid .
8997264	0	okadaic_acid	10,22	elastin	26,33	okadaic acid	elastin	MESH:D019319	2006	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of okadaic_acid on elastin gene expression in interstitial lung fibroblasts .
1658015	0	okadaic_acid	121,133	epidermal_growth_factor_receptor	33,65	okadaic acid	epidermal growth factor receptor	MESH:D019319	24329(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of the transmodulated epidermal_growth_factor_receptor by cholera toxin and the protein phosphatase inhibitor okadaic_acid .
9242459	0	okadaic_acid	87,99	insulin-like_growth_factor_I_receptor	25,62	okadaic acid	insulin-like growth factor I receptor	MESH:D019319	16001(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|effect effect|nmod|END_ENTITY	Protective effect of the insulin-like_growth_factor_I_receptor on apoptosis induced by okadaic_acid .
1662987	0	okadaic_acid	76,88	jun	27,30	okadaic acid	jun	MESH:D019319	3725	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|expression expression|compound|END_ENTITY	Differential regulation of jun family gene expression by the tumor promoter okadaic_acid .
8044794	0	okadaic_acid	39,51	p53	24,27	okadaic acid	p53	MESH:D019319	7157	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Hyperphosphorylation of p53 induced by okadaic_acid attenuates its transcriptional activation function .
1653727	0	okadaic_acid	56,68	phenylalanine_hydroxylase	18,43	okadaic acid	phenylalanine hydroxylase	MESH:D019319	5053	Chemical	Gene	modulation|nmod|START_ENTITY modulation|nmod|activity activity|amod|END_ENTITY	The modulation of phenylalanine_hydroxylase activity by okadaic_acid .
1313673	0	okadaic_acid	15,27	thrombin	47,55	okadaic acid	thrombin	MESH:D019319	2147	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of okadaic_acid and calyculin_A on thrombin induced platelet reaction .
21681559	0	olanzapine	135,145	AMP-activated_protein_kinase	24,52	olanzapine	AMP-activated protein kinase	MESH:C076029	78975(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|role role|nmod|END_ENTITY	A role for hypothalamic AMP-activated_protein_kinase in the mediation of hyperphagia and weight_gain induced by chronic treatment with olanzapine in female rats .
8822533	0	olanzapine	11,21	C-Fos	34,39	olanzapine	C-Fos	MESH:C076029	314322(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of olanzapine on regional C-Fos expression in rat forebrain .
17293706	0	olanzapine	77,87	C-reactive_protein	51,69	olanzapine	C-reactive protein	MESH:C076029	1401	Chemical	Gene	administration|amod|START_ENTITY END_ENTITY|nmod|administration	Insulin counter-regulatory factors , fibrinogen and C-reactive_protein during olanzapine administration : effects of the antidiabetic metformin .
10688158	0	olanzapine	34,44	Dopamine_D2_receptor	0,20	olanzapine	Dopamine D2 receptor	MESH:C076029	1813	Chemical	Gene	occupancy|nmod|START_ENTITY occupancy|amod|END_ENTITY	Dopamine_D2_receptor occupancy by olanzapine or risperidone in young patients with schizophrenia .
23147717	0	olanzapine	47,57	FMO1_and_3	13,23	olanzapine	FMO1 and 3	MESH:C076029	2326;2328	Chemical	Gene	polymorphisms|nmod|START_ENTITY polymorphisms|nsubj|Influence Influence|nmod|END_ENTITY	Influence of FMO1_and_3 polymorphisms on serum olanzapine and its N-oxide metabolite in psychiatric patients .
12551741	0	olanzapine	11,21	P300	34,38	olanzapine	P300	MESH:C076029	2033	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of olanzapine on auditory P300 in schizophrenia .
18321680	0	olanzapine	46,56	P300	158,162	olanzapine	P300	MESH:C076029	2033	Chemical	Gene	ability|nmod|START_ENTITY basis|nmod|ability basis|dep|analysis analysis|nmod|END_ENTITY	Electrophysiological basis for the ability of olanzapine to improve verbal memory and functional outcome in patients with schizophrenia : a LORETA analysis of P300 .
26922530	0	olanzapine	19,29	POMC	48,52	olanzapine	POMC	MESH:C076029	24664(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY administration|nmod|END_ENTITY	Effect of extended olanzapine administration on POMC and neuropeptide Y mRNA levels in the male rat amygdala and hippocampus .
19333405	0	olanzapine	20,30	Prolactin	0,9	olanzapine	Prolactin	MESH:C076029	5617	Chemical	Gene	correlate|amod|START_ENTITY levels|nmod|correlate levels|compound|END_ENTITY	Prolactin levels in olanzapine treatment correlate with positive symptoms of schizophrenia : results from an open-label , flexible-dose study .
17675105	0	olanzapine	8,18	Stat3	33,38	olanzapine	Stat3	MESH:C076029	25125(Tax:10116)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|pathway pathway|amod|END_ENTITY	Chronic olanzapine activates the Stat3 signal transduction pathway and alters expression of components of the 5-HT2A receptor signaling system in rat frontal cortex .
15101569	0	olanzapine	55,65	adiponectin	6,17	olanzapine	adiponectin	MESH:C076029	9370	Chemical	Gene	treatment|nmod|START_ENTITY concentrations|nmod|treatment concentrations|compound|END_ENTITY	Serum adiponectin concentrations during treatment with olanzapine or risperidone : a pilot study .
21511441	0	olanzapine	24,34	adiponectin	61,72	olanzapine	adiponectin	MESH:C076029	9370	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|levels levels|compound|END_ENTITY	Differential effects of olanzapine and risperidone on plasma adiponectin levels over time : results from a 3-month prospective open-label study .
20546816	0	olanzapine	11,21	brain-derived_neurotrophic_factor	25,58	olanzapine	brain-derived neurotrophic factor	MESH:C076029	627	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|amod|END_ENTITY	Effects of olanzapine on brain-derived_neurotrophic_factor gene promoter activity in SH-SY5Y neuroblastoma cells .
22960130	0	olanzapine	55,65	c-Fos	106,111	olanzapine	c-Fos	MESH:C076029	314322(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY substrates|nmod|effect revealed|nsubj|substrates revealed|nmod|immunoreactivity immunoreactivity|amod|END_ENTITY	Neuroanatomical substrates of the disruptive effect of olanzapine on rat maternal behavior as revealed by c-Fos immunoreactivity .
18662828	0	olanzapine	24,34	calcitonin_gene-related_peptide	67,98	olanzapine	calcitonin gene-related peptide	MESH:C076029	24241(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Differential effects of olanzapine , haloperidol and risperidone on calcitonin_gene-related_peptide in the rat brain .
19467289	0	olanzapine	11,21	corticotropin-releasing_hormone	40,71	olanzapine	corticotropin-releasing hormone	MESH:C076029	81648(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|release release|amod|END_ENTITY	Effects of olanzapine and quetiapine on corticotropin-releasing_hormone release in the rat brain .
21556042	0	olanzapine	21,31	ghrelin	35,42	olanzapine	ghrelin	MESH:C076029	59301(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|secretion secretion|compound|END_ENTITY	The acute effects of olanzapine on ghrelin secretion , CCK sensitivity , meal size , locomotor activity and body temperature .
12050274	0	olanzapine	94,104	insulin	34,41	olanzapine	insulin	MESH:C076029	3630	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|assessment assessment|nmod|responses responses|compound|END_ENTITY	Hyperglycemic clamp assessment of insulin secretory responses in normal subjects treated with olanzapine , risperidone , or placebo .
14671184	0	olanzapine	69,79	insulin	14,21	olanzapine	insulin	MESH:C076029	3630	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|Evaluation Evaluation|nmod|sensitivity sensitivity|compound|END_ENTITY	Evaluation of insulin sensitivity in healthy volunteers treated with olanzapine , risperidone , or placebo : a prospective , randomized study using the two-step hyperinsulinemic , euglycemic clamp .
16974193	0	olanzapine	20,30	insulin	50,57	olanzapine	insulin	MESH:C076029	3630	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	The early effect of olanzapine and risperidone on insulin secretion in atypical-na ve schizophrenic patients .
19412507	0	olanzapine	78,88	insulin	29,36	olanzapine	insulin	MESH:C076029	3630	Chemical	Gene	addition|nmod|START_ENTITY hypersecretion|nmod|addition hypersecretion|compound|END_ENTITY	Hypoglycemia associated with insulin hypersecretion following the addition of olanzapine to conventional antipsychotics .
20394794	0	olanzapine	86,96	insulin	29,36	olanzapine	insulin	MESH:C076029	3630	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|change change|nmod|secretion secretion|compound|END_ENTITY	The time-dependent change of insulin secretion in schizophrenic patients treated with olanzapine .
21139307	0	olanzapine	32,42	insulin	75,82	olanzapine	insulin	MESH:C076029	3630	Chemical	Gene	induced|nmod|START_ENTITY hyperglycemia|acl|induced improved|nsubjpass|hyperglycemia improved|nmod|recovery recovery|nmod|secretion secretion|compound|END_ENTITY	Severe hyperglycemia induced by olanzapine was improved with a recovery of insulin secretion after switching to risperidone and introducing insulin therapy .
21711373	0	olanzapine	103,113	insulin	52,59	olanzapine	insulin	MESH:C076029	3630	Chemical	Gene	therapy|amod|START_ENTITY retinol-binding_protein_4|nmod|therapy retinol-binding_protein_4|nmod|resistance resistance|compound|END_ENTITY	Association of serum retinol-binding_protein_4 with insulin resistance and metabolic parameters during olanzapine therapy .
23803867	0	olanzapine	104,114	insulin	8,15	olanzapine	insulin	MESH:C076029	3630	Chemical	Gene	treated|nmod|START_ENTITY treated|csubj|Fasting Fasting|dobj|levels levels|compound|END_ENTITY	Fasting insulin serum levels and psychopathology profiles in male schizophrenic inpatients treated with olanzapine or risperidone .
17314489	0	olanzapine	43,53	leptin	6,12	olanzapine	leptin	MESH:C076029	3952	Chemical	Gene	elevation|nmod|START_ENTITY elevation|compound|END_ENTITY	Rapid leptin elevation after initiation of olanzapine ?
21811193	0	olanzapine	108,118	leptin	53,59	olanzapine	leptin	MESH:C076029	3952	Chemical	Gene	treatment|compound|START_ENTITY levels|dep|treatment levels|compound|END_ENTITY	Plasma orexin A , ghrelin , cholecystokinin , visfatin , leptin and agouti-related protein levels during 6-week olanzapine treatment in first-episode male patients with psychosis .
15820421	0	olanzapine	18,28	nerve_growth_factor	42,61	olanzapine	nerve growth factor	MESH:C076029	310738(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY treatment|nmod|END_ENTITY	Effect of chronic olanzapine treatment on nerve_growth_factor and brain-derived_neurotrophic_factor in the rat brain .
11048906	0	olanzapine	15,25	prolactin	66,75	olanzapine	prolactin	MESH:C076029	5617	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	The effects of olanzapine , risperidone , and haloperidol on plasma prolactin levels in patients with schizophrenia .
11403983	0	olanzapine	11,21	prolactin	47,56	olanzapine	prolactin	MESH:C076029	5617	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|compound|END_ENTITY	Effects of olanzapine and haloperidol on serum prolactin levels in male schizophrenic patients .
12019665	0	olanzapine	11,21	prolactin	25,34	olanzapine	prolactin	MESH:C076029	5617	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|compound|END_ENTITY	Effects of olanzapine on prolactin levels of female patients with schizophrenia treated with risperidone .
15671135	0	olanzapine	63,73	prolactin	109,118	olanzapine	prolactin	MESH:C076029	5617	Chemical	Gene	refractory_schizophrenia|nmod|START_ENTITY treatment|nmod|refractory_schizophrenia treatment|nmod|pituitary_microadenoma pituitary_microadenoma|compound|END_ENTITY	Successful treatment of refractory_schizophrenia with combined olanzapine and quetiapine in a patient with a prolactin secreting pituitary_microadenoma .
16333653	0	olanzapine	39,49	prolactin	76,85	olanzapine	prolactin	MESH:C076029	24683(Tax:10116)	Chemical	Gene	antipsychotics|amod|START_ENTITY antipsychotics|nmod|levels levels|compound|END_ENTITY	Effects of the atypical antipsychotics olanzapine and risperidone on plasma prolactin levels in male rats : a comparison with clinical data .
16824658	0	olanzapine	53,63	prolactin	22,31	olanzapine	prolactin	MESH:C076029	5617	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|differences differences|nmod|elevation elevation|compound|END_ENTITY	Gender differences in prolactin elevation induced by olanzapine in Japanese drug-na ve schizophrenic patients .
21823168	0	olanzapine	26,36	prolactin	64,73	olanzapine	prolactin	MESH:C076029	5617	Chemical	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	Dose-dependent effects of olanzapine on QT intervals and plasma prolactin levels in Japanese patients with stable schizophrenia .
26816428	0	olanzapine	82,92	prolactin	50,59	olanzapine	prolactin	MESH:C076029	5617	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubj|study study|nmod|level level|compound|END_ENTITY	Comparative study of sexual_dysfunction and serum prolactin level associated with olanzapine , risperidone , and clozapine in patients with remitted schizophrenia .
21711373	0	olanzapine	103,113	retinol-binding_protein_4	21,46	olanzapine	retinol-binding protein 4	MESH:C076029	5950	Chemical	Gene	therapy|amod|START_ENTITY END_ENTITY|nmod|therapy	Association of serum retinol-binding_protein_4 with insulin resistance and metabolic parameters during olanzapine therapy .
10213477	0	olanzapine	24,34	superoxide_dismutase	61,81	olanzapine	superoxide dismutase	MESH:C076029	24786(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Differential effects of olanzapine on the gene expression of superoxide_dismutase and the low_affinity_nerve_growth_factor_receptor .
24431454	0	oleandrin	90,99	BDNF	0,4	oleandrin	BDNF	MESH:C021065	627	Chemical	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	BDNF mediates neuroprotection against oxygen-glucose_deprivation by the cardiac glycoside oleandrin .
20100471	0	oleanolic_acid	26,40	Nrf2	68,72	oleanolic acid	Nrf2	MESH:D009828	4780	Chemical	Gene	activities|nmod|START_ENTITY activities|dep|role role|nmod|kinases kinases|compound|END_ENTITY	Antioxidant activities of oleanolic_acid in vitro : possible role of Nrf2 and MAP kinases .
23531458	0	oleanolic_acid	39,53	PTP1B	69,74	oleanolic acid	PTP1B	MESH:D009828	5770	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Synthesis and biological evaluation of oleanolic_acid derivatives as PTP1B inhibitors .
21681438	0	oleanolic_acid	185,199	cyclooxygenase-2	119,135	oleanolic acid	cyclooxygenase-2	MESH:D009828	5743	Chemical	Gene	role|nmod|START_ENTITY expression|dep|role expression|amod|END_ENTITY	Triacylglycerol-rich lipoproteins derived from healthy donors fed different olive oils modulate cytokine secretion and cyclooxygenase-2 expression in macrophages : the potential role of oleanolic_acid .
21246613	0	oleanolic_acid	32,46	mTOR	14,18	oleanolic acid	mTOR	MESH:D009828	21977(Tax:10090)	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Inhibition of mTOR signaling by oleanolic_acid contributes to its anti-tumor activity in osteosarcoma cells .
20964318	0	oleanolic_acid	39,53	protein_tyrosine_phosphatase_1B	83,114	oleanolic acid	protein tyrosine phosphatase 1B	MESH:D009828	5770	Chemical	Gene	derivatives|amod|START_ENTITY evaluation|nmod|derivatives evaluation|nmod|inhibitors inhibitors|nmod|END_ENTITY	Synthesis and biological evaluation of oleanolic_acid derivatives as inhibitors of protein_tyrosine_phosphatase_1B .
24721313	0	oleanolic_acid	36,50	protein_tyrosine_phosphatase_1B	70,101	oleanolic acid	protein tyrosine phosphatase 1B	MESH:D009828	5770	Chemical	Gene	Synthesis|nmod|START_ENTITY glycoconjugates|nsubj|Synthesis glycoconjugates|nmod|inhibitors inhibitors|amod|END_ENTITY	Synthesis and evaluation of several oleanolic_acid glycoconjugates as protein_tyrosine_phosphatase_1B inhibitors .
19463989	0	oleanolic_acid_saponins	39,62	pancreatic_lipase	98,115	oleanolic acid saponins	pancreatic lipase	null	5406	Chemical	Gene	synthesis|nmod|START_ENTITY synthesis|nmod|END_ENTITY	Facile synthesis of three bidesmosidic oleanolic_acid_saponins with strong inhibitory activity on pancreatic_lipase .
16753968	0	oleate	30,36	Lysozyme	0,8	oleate	Lysozyme	MESH:D019301	4069	Chemical	Gene	effect|nmod|START_ENTITY effect|amod|END_ENTITY	Lysozyme effect on oleic_acid / oleate vesicles .
26976120	0	oleate	8,14	PGC-1a	65,71	oleate	PGC-1a	MESH:D019301	19017(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Hepatic oleate regulates liver stress response partially through PGC-1a during high-carbohydrate feeding .
23829768	0	olefin	67,73	HO2	61,64	olefin	HO2	CHEBI:32878	3163	Chemical	Gene	channels|compound|START_ENTITY channels|nummod|END_ENTITY	Rate rules , branching ratios , and pressure dependence of the HO2 + olefin addition channels .
1543735	1	olefin	162,168	cytochrome_P-450	178,194	olefin	cytochrome P-450	CHEBI:32878	4051	Chemical	Gene	hydroxylation|nmod|START_ENTITY hydroxylation|nmod|END_ENTITY	Omega hydroxylation of cis and trans_unsaturated_lauric_acid analogs and epoxygenation of the terminal olefin by plant cytochrome_P-450 .
26439040	0	oleic_acid	11,21	SP-B	25,29	oleic acid	SP-B	MESH:D019301	6439	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effects of oleic_acid on SP-B expression and release in A549 cells .
23654101	0	oleic_acid	12,22	adiponectin	40,51	oleic acid	adiponectin	MESH:D019301	9370	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of oleic_acid on expression of adiponectin and its PPARgamma mechanism in 3T3-L1 adipocytes -RSB- .
2474848	0	oleic_acid	11,21	cholecystokinin	43,58	oleic acid	cholecystokinin	MESH:D019301	885	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of oleic_acid and oleyl_alcohol on cholecystokinin and secretin in plasma and pancreatobiliary secretion .
8464169	0	oleic_acid	106,116	cholecystokinin	8,23	oleic acid	cholecystokinin	MESH:D019301	25298(Tax:10116)	Chemical	Gene	-RSB-|amod|START_ENTITY injection|nmod|-RSB- induced|nmod|injection induced|nsubj|levels levels|compound|END_ENTITY	-LSB- Plasma cholecystokinin levels in rats with pancreatic_insufficiency induced by intra ductal injection of oleic_acid -RSB- .
8594945	0	oleic_acid	73,83	cholecystokinin	8,23	oleic acid	cholecystokinin	MESH:D019301	25298(Tax:10116)	Chemical	Gene	delivery|nmod|START_ENTITY produced|nmod|delivery produced|nsubj|Role Role|nmod|END_ENTITY	Role of cholecystokinin in the anorexia produced by duodenal delivery of oleic_acid in rats .
9138250	0	oleic_acid	93,103	cholecystokinin	40,55	oleic acid	cholecystokinin	MESH:D019301	25298(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|Involvement Involvement|nmod|processes processes|nmod|END_ENTITY	Involvement of cholinergic processes in cholecystokinin -LRB- CCK -RRB- release -LSB- corrected -RSB- by luminal oleic_acid .
1989527	0	oleic_acid	54,64	cytochrome_b5	12,25	oleic acid	cytochrome b5	MESH:D019301	106318209	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	The role of cytochrome_b5 in delta 12 desaturation of oleic_acid by microsomes of safflower -LRB- Carthamus tinctorius L. -RRB- .
2853632	0	oleic_acid	10,20	cytochrome_c	38,50	oleic acid	cytochrome c	MESH:D019301	54205	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	Effect of oleic_acid on mitochondrial cytochrome_c oxidase activity .
22253973	0	oleic_acid	43,53	hepatic_lipase	14,28	oleic acid	hepatic lipase	MESH:D019301	3990	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Activation of hepatic_lipase expression by oleic_acid : possible involvement of USF1 .
10700478	0	oleic_acid	60,70	insulin	74,81	oleic acid	insulin	MESH:D019301	3630	Chemical	Gene	START_ENTITY|nmod|sensitivity sensitivity|compound|END_ENTITY	Diabetes and the Mediterranean diet : a beneficial effect of oleic_acid on insulin sensitivity , adipocyte glucose transport and endothelium-dependent vasoreactivity .
15935394	0	oleic_acid	14,24	insulin	42,49	oleic acid	insulin	MESH:D019301	3630	Chemical	Gene	deterioration|amod|START_ENTITY deterioration|nmod|secretion secretion|compound|END_ENTITY	Mechanisms of oleic_acid deterioration in insulin secretion : role in the pathogenesis of type 2 diabetes .
1532491	0	oleic_acid	35,45	plasmin	15,22	oleic acid	plasmin	MESH:D019301	5340	Chemical	Gene	Stimulation|nmod|START_ENTITY Stimulation|nmod|activity activity|compound|END_ENTITY	Stimulation of plasmin activity by oleic_acid .
18848587	0	oleoyl-estrone	16,30	ghrelin	59,66	oleoyl-estrone	ghrelin	MESH:C108709	59301(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|nmod|END_ENTITY	Short-term oral oleoyl-estrone decreases the expression of ghrelin in the rat stomach .
10690640	0	oleoyl_imidazolide	94,112	phospholipase_A2	36,52	oleoyl imidazolide	phospholipase A2	MESH:C018353	151056	Chemical	Gene	venom|nmod|START_ENTITY END_ENTITY|nmod|venom	Activation of the acidic isoform of phospholipase_A2 from Naja mossambica mossambica venom by oleoyl_imidazolide requires the cooperative action of two ionizing groups .
720331	0	oleoyl_imidazolide	44,62	phospholipase_A2	24,40	oleoyl imidazolide	phospholipase A2	MESH:C018353	406141(Tax:7460)	Chemical	Gene	venom|nmod|START_ENTITY venom|dobj|END_ENTITY	Activation of bee venom phospholipase_A2 by oleoyl_imidazolide .
20029832	0	oleoylethanolamide	46,64	PPAR-alpha	26,36	oleoylethanolamide	PPAR-alpha	MESH:C488250	19013(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|agonist agonist|amod|END_ENTITY	Effects of the endogenous PPAR-alpha agonist , oleoylethanolamide on MDMA-induced cognitive_deficits in mice .
12761211	0	oleoylethanolamide	42,60	TRPV1	14,19	oleoylethanolamide	TRPV1	MESH:C488250	100462763	Chemical	Gene	START_ENTITY|nsubj|Activation Activation|nmod|END_ENTITY	Activation of TRPV1 by the satiety factor oleoylethanolamide .
22480617	0	oleoylethanolamide	20,38	peroxisome_proliferator-activated_receptor_a	103,147	oleoylethanolamide	peroxisome proliferator-activated receptor a	MESH:C488250	19013(Tax:10090)	Chemical	Gene	protects|nsubj|START_ENTITY protects|advcl|activating activating|dobj|END_ENTITY	Orally administered oleoylethanolamide protects mice from focal cerebral_ischemic_injury by activating peroxisome_proliferator-activated_receptor_a .
22395142	0	oleuropein	10,20	myeloperoxidase	31,46	oleuropein	myeloperoxidase	MESH:C002769	303413(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of oleuropein on tissue myeloperoxidase activity in experimental spinal_cord_trauma .
2860909	0	oligomycin	67,77	OSCP	26,30	oligomycin	OSCP	MESH:D009840	539	Chemical	Gene	confers|advcl|START_ENTITY structure|acl:relcl|confers structure|nmod|protein protein|compound|END_ENTITY	-LSB- Primary structure of the OSCP protein that confers sensitivity to oligomycin on the mitochondrial H + - ATPase complex .
9753477	0	oligomycin	4,14	OSCP	131,135	oligomycin	OSCP	MESH:D009840	192241(Tax:10116)	Chemical	Gene	sensitivity|compound|START_ENTITY conferring|nsubj|sensitivity conferring|parataxis|important important|nmod|the the|nmod|F1 F1|compound|END_ENTITY	The oligomycin sensitivity conferring protein of rat liver mitochondrial ATP synthase : arginine 94 is important for the binding of OSCP to F1 .
22494992	0	olmesartan	80,90	ABCC2	13,18	olmesartan	ABCC2	MESH:C437965	1244	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY polymorphisms|nmod|pharmacokinetics polymorphisms|nsubj|Influence Influence|nmod|END_ENTITY	Influence of ABCC2 , SLCO1B1 , and ABCG2 polymorphisms on the pharmacokinetics of olmesartan .
17089097	0	olmesartan	11,21	AT1	26,29	olmesartan	AT1	MESH:C437965	11607(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Effects of olmesartan , an AT1 receptor antagonist , on hypoxia-induced activation of ERK1/2 and pro-inflammatory signals in the mouse lung .
21843501	0	olmesartan	66,76	AT1	51,54	olmesartan	AT1	MESH:C437965	185	Chemical	Gene	START_ENTITY|nsubj|properties properties|nmod|antagonist antagonist|compound|END_ENTITY	Thermal , dynamic and structural properties of drug AT1 antagonist olmesartan in lipid bilayers .
19057515	0	olmesartan	73,83	AT1_receptor	51,63	olmesartan	AT1 receptor	MESH:C437965	11610(Tax:10090)	Chemical	Gene	blocker|appos|START_ENTITY blocker|amod|END_ENTITY	Prevention of vascular_injury by combination of an AT1_receptor blocker , olmesartan , with various calcium antagonists .
24187471	0	olmesartan	26,36	Angiotensin-II	0,14	olmesartan	Angiotensin-II	MESH:C437965	183	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Angiotensin-II inhibitor -LRB- olmesartan -RRB- - induced collagenous_sprue with resolution following discontinuation of drug .
26138656	0	olmesartan	35,45	Angiotensin_II	0,14	olmesartan	Angiotensin II	MESH:C437965	183	Chemical	Gene	inhibitor|compound|START_ENTITY antagonist|dobj|inhibitor antagonist|nsubj|receptor receptor|compound|END_ENTITY	Angiotensin_II receptor antagonist olmesartan and NF-kappaB inhibitor as cytotoxic and apoptotic agents in MCF-7 human cell line .
18300871	0	olmesartan	40,50	Angiotensin_II_type_1_receptor	0,30	olmesartan	Angiotensin II type 1 receptor	MESH:C437965	185	Chemical	Gene	blocker|appos|START_ENTITY blocker|amod|END_ENTITY	Angiotensin_II_type_1_receptor blocker , olmesartan , restores nocturnal blood pressure decline by enhancing daytime natriuresis .
17089097	0	olmesartan	11,21	ERK1/2	84,90	olmesartan	ERK1/2	MESH:C437965	26417;26413	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Effects of olmesartan , an AT1 receptor antagonist , on hypoxia-induced activation of ERK1/2 and pro-inflammatory signals in the mouse lung .
12939523	0	olmesartan	38,48	angiotensin_II	56,70	olmesartan	angiotensin II	MESH:C437965	183	Chemical	Gene	START_ENTITY|appos|type type|compound|END_ENTITY	The preferential inhibitory effect of olmesartan , a new angiotensin_II type 1 antagonist , on sympathetic nerve terminals in isolated canine splenic artery .
14574081	0	olmesartan	11,21	angiotensin_II	26,40	olmesartan	angiotensin II	MESH:C437965	24179(Tax:10116)	Chemical	Gene	START_ENTITY|appos|blocker blocker|amod|END_ENTITY	Effects of olmesartan , an angiotensin_II receptor blocker , on mechanically-modulated genes in cardiac myocytes .
16501004	0	olmesartan	70,80	angiotensin_II	90,104	olmesartan	angiotensin II	MESH:C437965	183	Chemical	Gene	START_ENTITY|appos|blocker blocker|compound|END_ENTITY	OATP1B1 , OATP1B3 , and mrp2 are involved in hepatobiliary transport of olmesartan , a novel angiotensin_II blocker .
16755152	0	olmesartan	161,171	angiotensin_II	27,41	olmesartan	angiotensin II	MESH:C437965	24179(Tax:10116)	Chemical	Gene	dose|nmod|START_ENTITY effects|nmod|dose Augmentation|dep|effects Augmentation|nmod|levels levels|compound|END_ENTITY	Augmentation of intrarenal angiotensin_II levels in uninephrectomized aldosterone/salt-treated hypertensive rats ; renoprotective effects of an ultrahigh dose of olmesartan .
15124927	0	olmesartan	22,32	angiotensin_II_receptor_type_1	42,72	olmesartan	angiotensin II receptor type 1	MESH:C437965	81638(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Beneficial effects of olmesartan , a novel angiotensin_II_receptor_type_1 antagonist , upon acute autoimmune_myocarditis .
20876084	0	olmesartan	22,32	angiotensin_II_receptor_type_1	37,67	olmesartan	angiotensin II receptor type 1	MESH:C437965	81638(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Beneficial effects of olmesartan , an angiotensin_II_receptor_type_1 antagonist , in rats with dilated_cardiomyopathy .
20638619	0	olmesartan	67,77	angiotensin_II_type-1_receptor	22,52	olmesartan	angiotensin II type-1 receptor	MESH:C437965	81638(Tax:10116)	Chemical	Gene	blockade|nmod|START_ENTITY blockade|amod|END_ENTITY	Protective effects of angiotensin_II_type-1_receptor blockade with olmesartan on spinal cord_ischemia-reperfusion injury : an experimental study on rats .
18434761	0	olmesartan	47,57	angiotensin_II_type_1_receptor	62,92	olmesartan	angiotensin II type 1 receptor	MESH:C437965	403836(Tax:9615)	Chemical	Gene	dogs|nmod|START_ENTITY myocardium|nmod|dogs Improvement|nmod|myocardium Improvement|appos|antagonist antagonist|amod|END_ENTITY	Improvement of stunned myocardium in dogs with olmesartan , an angiotensin_II_type_1_receptor antagonist , is independent of type 2 receptors .
19891533	0	olmesartan	56,66	angiotensin_II_type_1_receptor	14,44	olmesartan	angiotensin II type 1 receptor	MESH:C437965	185	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|antagonist antagonist|amod|END_ENTITY	Effect of the angiotensin_II_type_1_receptor antagonist olmesartan on cerebral hemodynamics and rehabilitation outcomes in hypertensive post-stroke patients .
20074257	0	olmesartan	73,83	angiotensin_II_type_1_receptor	28,58	olmesartan	angiotensin II type 1 receptor	MESH:C437965	81638(Tax:10116)	Chemical	Gene	blockade|nmod|START_ENTITY blockade|amod|END_ENTITY	Cardioprotective effects of angiotensin_II_type_1_receptor blockade with olmesartan on reperfusion injury in a rat myocardial_ischemia-reperfusion model .
23113965	0	olmesartan	47,57	insulin	90,97	olmesartan	insulin	MESH:C437965	3630	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|resistance resistance|compound|END_ENTITY	Effects of manidipine plus rosuvastatin versus olmesartan plus rosuvastatin on markers of insulin resistance in patients with impaired fasting glucose , hypertension , and mixed dyslipidemia .
24288395	0	olmesartan	36,46	osteoprotegerin	73,88	olmesartan	osteoprotegerin	MESH:C437965	4982	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of combination therapy with olmesartan and azelnidipine on serum osteoprotegerin in patients with hypertension .
12871826	0	olmesartan_medoxomil	46,66	angiotensin_II_type_1_receptor	3,33	olmesartan medoxomil	angiotensin II type 1 receptor	MESH:C097933	81638(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	An angiotensin_II_type_1_receptor antagonist , olmesartan_medoxomil , improves experimental liver_fibrosis by suppression of proliferation and collagen synthesis in activated hepatic stellate cells .
21184621	0	olmesartan_medoxomil	11,31	angiotensin_II_type_1_receptor	36,66	olmesartan medoxomil	angiotensin II type 1 receptor	MESH:C097933	185	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Effects of olmesartan_medoxomil , an angiotensin_II_type_1_receptor antagonist , on plasma concentration of B-type_natriuretic_peptide , in hypertensive patients with type 2 diabetes_mellitus : a preliminary , observational , open-label study .
26240115	0	olmesartan_medoxomil	112,132	angiotensin_II_type_1_receptor	16,46	olmesartan medoxomil	angiotensin II type 1 receptor	MESH:C097933	185	Chemical	Gene	Effect|nmod|START_ENTITY blocking|dep|Effect blocking|nmod|activity activity|compound|END_ENTITY	The blocking of angiotensin_II_type_1_receptor and RhoA/Rho kinase activity in hypertensive patients : Effect of olmesartan_medoxomil and implication with cardiovascular-renal_remodeling .
19521888	0	olmesartan_medoxomil	10,30	cystatin_C	34,44	olmesartan medoxomil	cystatin C	MESH:C097933	1471	Chemical	Gene	START_ENTITY|nmod|level level|amod|END_ENTITY	Effect of olmesartan_medoxomil on cystatin_C level , left_ventricular_hypertrophy and diastolic function .
15013847	0	olopatadine	78,89	IL-4	27,31	olopatadine	IL-4	MESH:C074921	287287(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Differential regulation of IL-4 expression and degranulation by anti-allergic olopatadine in rat_basophilic_leukemia -LRB- RBL-2H3 -RRB- cells .
9455080	0	olprinone	12,21	IL-6	25,29	olprinone	IL-6	MESH:C059498	3569	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|production production|amod|END_ENTITY	-LSB- Effects of olprinone on IL-6 and IL-10 production during and after cardiac surgery -RSB- .
11459203	0	oltipraz	47,55	CYP1A2	28,34	oltipraz	CYP1A2	MESH:C026209	1544	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	In vivo inhibition of human CYP1A2 activity by oltipraz .
19833192	0	oltipraz	82,90	CYP2B6	56,62	oltipraz	CYP2B6	MESH:C026209	1555	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Involvement of pregnane_X_receptor in the regulation of CYP2B6 gene expression by oltipraz in human hepatocytes .
15047705	0	oltipraz	59,67	NF-kappaB	0,9	oltipraz	NF-kappaB	MESH:C026209	4790	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	NF-kappaB activation by the chemopreventive dithiolethione oltipraz is exerted through stimulation of MEKK3 signaling .
12488544	0	oltipraz	62,70	UDP-glucuronosyltransferase_1A6	17,48	oltipraz	UDP-glucuronosyltransferase 1A6	MESH:C026209	113992(Tax:10116)	Chemical	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	Mechanism of rat UDP-glucuronosyltransferase_1A6 induction by oltipraz : evidence for a contribution of the Aryl_hydrocarbon receptor pathway .
9203627	0	oltipraz	116,124	Yc2	93,96	oltipraz	Yc2	MESH:C026209	494500(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Enhancement of radiation-inducible hepatic glutathione-S-transferases Ya , Yb1 , Yb2 , Yc1 , and Yc2 gene expression by oltipraz : possible role in radioprotection .
1520294	0	omega,omega,omega-triphenylalcohols	95,130	UDP-glucuronosyltransferase	53,80	omega,omega,omega-triphenylalcohols	UDP-glucuronosyltransferase	null	24862(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|activities activities|amod|END_ENTITY	Selective and potent inhibition of different hepatic UDP-glucuronosyltransferase activities by omega,omega,omega-triphenylalcohols and UDP derivatives .
21799946	0	omega-3_Fatty_acids	15,34	matrix_metalloproteinase-9	38,64	omega-3 Fatty acids	matrix metalloproteinase-9	MESH:D015525	4318	Chemical	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	The effects of omega-3_Fatty_acids on matrix_metalloproteinase-9 production and cell migration in human immune cells : implications for multiple_sclerosis .
8534855	0	omega-3_fatty_acid	111,129	FAD7	147,151	omega-3 fatty acid	FAD7	CHEBI:25681	820288(Tax:3702)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Tissue-specific and light-responsive regulation of the promoter region of the Arabidopsis_thaliana chloroplast omega-3_fatty_acid desaturase gene -LRB- FAD7 -RRB- .
9368411	0	omega-3_fatty_acid	75,93	FAD7	111,115	omega-3 fatty acid	FAD7	CHEBI:25681	820288(Tax:3702)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Wounding changes the spatial expression pattern of the arabidopsis plastid omega-3_fatty_acid desaturase gene -LRB- FAD7 -RRB- through different signal transduction pathways .
20813258	0	omega-3_fatty_acid	13,31	GPR120	0,6	omega-3 fatty acid	GPR120	CHEBI:25681	107221(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|nsubj|END_ENTITY	GPR120 is an omega-3_fatty_acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects .
12384076	0	omega-3_fatty_acid	97,115	tumor_necrosis_factor-alpha	55,82	omega-3 fatty acid	tumor necrosis factor-alpha	CHEBI:25681	7124	Chemical	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Modulation of lipopolysaccharide-stimulated macrophage tumor_necrosis_factor-alpha production by omega-3_fatty_acid is associated with differential cyclooxygenase-2 protein expression and is independent of interleukin-10 .
18638380	0	omega-3_fatty_acid	4,22	tumour_necrosis_factor	86,108	omega-3 fatty acid	tumour necrosis factor	CHEBI:25681	21926(Tax:10090)	Chemical	Gene	prevents|nsubj|START_ENTITY prevents|dobj|effects effects|nmod|END_ENTITY	The omega-3_fatty_acid , eicosapentaenoic_acid -LRB- EPA -RRB- , prevents the damaging effects of tumour_necrosis_factor -LRB- TNF -RRB- - alpha during murine skeletal muscle cell differentiation .
27000704	0	omega-3_fatty_acids	22,41	G_protein-coupled_receptor_120	127,157	omega-3 fatty acids	G protein-coupled receptor 120	MESH:D015525	294075(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|involvement involvement|nmod|END_ENTITY	Inhibitory effects of omega-3_fatty_acids on early brain_injury after subarachnoid_hemorrhage in rats : Possible involvement of G_protein-coupled_receptor_120 / b-arrestin2 / TGF-b activated kinase-1 binding protein-1 signaling pathway .
27000704	0	omega-3_fatty_acids	22,41	TGF-b	170,175	omega-3 fatty acids	TGF-b	MESH:D015525	59086(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nsubj|effects	Inhibitory effects of omega-3_fatty_acids on early brain_injury after subarachnoid_hemorrhage in rats : Possible involvement of G_protein-coupled_receptor_120 / b-arrestin2 / TGF-b activated kinase-1 binding protein-1 signaling pathway .
17038422	0	omega-3_polyunsaturated_fatty_acids	28,63	TRPV1	0,5	omega-3 polyunsaturated fatty acids	TRPV1	null	7442	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	TRPV1 is a novel target for omega-3_polyunsaturated_fatty_acids .
12578976	0	omega-6_and_omega-3_polyunsaturated_fatty_acids	51,98	COX-2	102,107	omega-6 and omega-3 polyunsaturated fatty acids	COX-2	null	4513	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Differential effects of prostaglandin derived from omega-6_and_omega-3_polyunsaturated_fatty_acids on COX-2 expression and IL-6 secretion .
26525102	0	omega-6_fatty_acid	44,62	C-reactive_protein	14,32	omega-6 fatty acid	C-reactive protein	CHEBI:36009	1401	Chemical	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Modulation of C-reactive_protein and plasma omega-6_fatty_acid levels by phospholipase_A2 gene polymorphisms following a 6-week supplementation with fish oil .
10806298	0	omega-6_polyunsaturated_fatty_acid	10,44	BRCA1	64,69	omega-6 polyunsaturated fatty acid	BRCA1	null	672	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of omega-6_polyunsaturated_fatty_acid -LRB- linoleic_acid -RRB- on BRCA1 gene expression in MCF-7 cell line .
10100022	0	omeprazole	68,78	CYP1A1	47,53	omeprazole	CYP1A1	MESH:D009853	1543	Chemical	Gene	differences|nmod|START_ENTITY differences|nmod|END_ENTITY	Species differences in hepatocyte induction of CYP1A1 and CYP1A2 by omeprazole .
10073749	0	omeprazole	19,29	CYP2C19	54,61	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	index|amod|START_ENTITY index|nmod|phenotyping phenotyping|compound|END_ENTITY	Reliability of the omeprazole hydroxylation index for CYP2C19 phenotyping : possible effect of age , liver_disease and length of therapy .
10215728	0	omeprazole	87,97	CYP2C19	10,17	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	treatment|compound|START_ENTITY patients|nmod|treatment polymorphism|nmod|patients polymorphism|nsubj|Effect Effect|nmod|END_ENTITY	Effect of CYP2C19 polymorphism on serum levels of vitamin_B12 in patients on long-term omeprazole treatment .
10233213	0	omeprazole	69,79	CYP2C19	46,53	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	measured|nmod|START_ENTITY activity|advcl|measured activity|nmod|END_ENTITY	Ticlopidine decreases the in vivo activity of CYP2C19 as measured by omeprazole metabolism .
10340921	0	omeprazole	38,48	CYP2C19	0,7	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	status|nmod|START_ENTITY genotype|dobj|status genotype|nsubj|END_ENTITY	CYP2C19 genotype status and effect of omeprazole on intragastric pH in humans .
10511062	0	omeprazole	47,57	CYP2C19	73,80	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	START_ENTITY|nmod|relation relation|nmod|END_ENTITY	Effects of clarithromycin on the metabolism of omeprazole in relation to CYP2C19 genotype status in humans .
10519449	0	omeprazole	10,20	CYP2C19	99,106	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	START_ENTITY|dep|use use|acl|assess assess|dobj|bioequivalence bioequivalence|nmod|phenotyping phenotyping|compound|END_ENTITY	High-dose omeprazole : use of a multiple-dose study design to assess bioequivalence and accuracy of CYP2C19 phenotyping .
10626755	0	omeprazole	27,37	CYP2C19	82,89	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	analysis|nmod|START_ENTITY supports|nsubj|analysis supports|nmod|inducer inducer|nmod|END_ENTITY	Stereospecific analysis of omeprazole supports artemisinin as a potent inducer of CYP2C19 .
10982760	0	omeprazole	11,21	CYP2C19	81,88	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	Effects|nmod|START_ENTITY dependent|nsubj|Effects dependent|nmod|polymorphism polymorphism|compound|END_ENTITY	Effects of omeprazole on intragastric pH and plasma gastrin are dependent on the CYP2C19 polymorphism .
11046127	0	omeprazole	19,29	CYP2C19	102,109	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	fractions|amod|START_ENTITY 5-hydroxylation|nmod|fractions related|nsubj|5-hydroxylation related|nmod|dose dose|compound|END_ENTITY	5-hydroxylation of omeprazole by human liver microsomal fractions from Chinese populations related to CYP2C19 gene dose and individual ethnicity .
11309556	0	omeprazole	10,20	CYP2C19	101,108	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|polymorphism polymorphism|nmod|END_ENTITY	Effect of omeprazole on the pharmacokinetics of moclobemide according to the genetic polymorphism of CYP2C19 .
11736724	0	omeprazole	62,72	CYP2C19	11,18	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	metabolism|nmod|START_ENTITY differences|nmod|metabolism differences|nummod|END_ENTITY	Effects of CYP2C19 genotypic differences in the metabolism of omeprazole and rabeprazole on intragastric pH. BACKGROUND : Omeprazole is mainly metabolized in the liver by CYP2C19 , a genetically determined enzyme , whereas rabeprazole is mainly reduced non-enzymatically and partially metabolized by CYP2C19 .
12132671	0	omeprazole	16,26	CYP2C19	31,38	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	START_ENTITY|nmod|metabolizers metabolizers|nummod|END_ENTITY	Optimal dose of omeprazole for CYP2C19 extensive metabolizers in anti-Helicobacter pylori therapy : pharmacokinetic considerations .
12401374	0	omeprazole	52,62	CYP2C19	13,20	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	Phenotype|nmod|START_ENTITY Phenotype|nmod|END_ENTITY	Phenotype of CYP2C19 and CYP3A4 by determination of omeprazole and its two main metabolites in plasma using liquid chromatography with liquid-liquid extraction .
12485723	0	omeprazole	27,37	CYP2C19	69,76	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	START_ENTITY|nmod|plasma plasma|nmod|probe probe|nmod|END_ENTITY	Stereospecific analysis of omeprazole in human plasma as a probe for CYP2C19 phenotype .
12623762	0	omeprazole	57,67	CYP2C19	71,78	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	metabolism|nmod|START_ENTITY troleandomycin|nmod|metabolism effect|nmod|troleandomycin genotype-dependent|nsubj|effect genotype-dependent|advmod|END_ENTITY	Inhibitory effect of troleandomycin on the metabolism of omeprazole is CYP2C19 genotype-dependent .
15025747	0	omeprazole	46,56	CYP2C19	76,83	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|nmod|END_ENTITY	Different inhibitory effect of fluvoxamine on omeprazole metabolism between CYP2C19 genotypes .
15317824	0	omeprazole	72,82	CYP2C19	87,94	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	variability|nmod|START_ENTITY dependency|dobj|variability dependency|nmod|phenotyping phenotyping|compound|END_ENTITY	Lack of weight-based dose dependency and intraindividual variability of omeprazole for CYP2C19 phenotyping .
15662508	0	omeprazole	65,75	CYP2C19	18,25	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	index|nmod|START_ENTITY genotype|nmod|index genotype|nsubj|effect effect|nmod|END_ENTITY	The effect of the CYP2C19 genotype on the hydroxylation index of omeprazole in South Indians .
15932363	0	omeprazole	61,71	CYP2C19	10,17	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	safety|nmod|START_ENTITY polymorphism|nmod|safety polymorphism|nsubj|Effect Effect|nmod|END_ENTITY	Effect of CYP2C19 polymorphism on the safety and efficacy of omeprazole in Japanese patients with recurrent reflux_oesophagitis .
16093273	0	omeprazole	68,78	CYP2C19	127,134	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	isomers|nmod|START_ENTITY interactions|dep|isomers interactions|dep|role role|nmod|END_ENTITY	Enantiomer/enantiomer interactions between the S - and R - isomers of omeprazole in human cytochrome_P450 enzymes : major role of CYP2C19 and CYP3A4 .
16413245	11	omeprazole	2085,2095	CYP2C19	2032,2039	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	area|amod|START_ENTITY attain|dobj|area attain|nsubj|homozygotes homozygotes|nummod|END_ENTITY	Predictions revealed that CYP2C19 * 17 homozygotes would attain 35 % to 40 % lower omeprazole area under the plasma concentration-time curve values than subjects homozygous for CYP2C19 * 1 taking standard doses of omeprazole .
16413245	11	omeprazole	2214,2224	CYP2C19	2032,2039	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	doses|nmod|START_ENTITY taking|dobj|doses attain|xcomp|taking attain|nsubj|homozygotes homozygotes|nummod|END_ENTITY	Predictions revealed that CYP2C19 * 17 homozygotes would attain 35 % to 40 % lower omeprazole area under the plasma concentration-time curve values than subjects homozygous for CYP2C19 * 1 taking standard doses of omeprazole .
16497565	0	omeprazole	27,37	CYP2C19	195,202	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	determination|nmod|START_ENTITY determination|dep|application application|nmod|study study|nmod|genotypes genotypes|nummod|END_ENTITY	Sensitive determination of omeprazole and its two main metabolites in human plasma by column-switching high-performance liquid chromatography : application to pharmacokinetic study in relation to CYP2C19 genotypes .
16953457	0	omeprazole	45,55	CYP2C19	106,113	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|nmod|metabolizers metabolizers|nmod|END_ENTITY	Finasteride 1 mg has no inhibitory effect on omeprazole metabolism in extensive and poor metabolizers for CYP2C19 in Japanese .
17047431	0	omeprazole	97,107	CYP2C19	14,21	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	effect|nmod|START_ENTITY Influence|nmod|effect Influence|nmod|polymorphism polymorphism|compound|END_ENTITY	-LSB- Influence of CYP2C19 polymorphism and Helicobacter_pylori status on the antisecretory effect of omeprazole in gastroesophageal_reflux_disease -RSB- .
17203292	0	omeprazole	43,53	CYP2C19	69,76	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	bioavailability|nmod|START_ENTITY Absolute|dobj|bioavailability Absolute|nmod|genotypes genotypes|nummod|END_ENTITY	Absolute bioavailability and metabolism of omeprazole in relation to CYP2C19 genotypes following single intravenous and oral administrations .
17701405	0	omeprazole	38,48	CYP2C19	14,21	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	index|amod|START_ENTITY Estimation|nmod|index Estimation|nmod|activity activity|compound|END_ENTITY	Estimation of CYP2C19 activity by the omeprazole hydroxylation index at a single point in time after intravenous and oral administration .
17875119	0	omeprazole	88,98	CYP2C19	11,18	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY Effects|nmod|pharmacokinetics Effects|nmod|polymorphism polymorphism|compound|END_ENTITY	Effects of CYP2C19 genetic polymorphism on the pharmacokinetics and pharmacodynamics of omeprazole in Chinese people .
17934830	0	omeprazole	69,79	CYP2C19	111,118	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	treatment|nmod|START_ENTITY treatment|nmod|relation relation|nmod|END_ENTITY	Endoscopic analysis of gastric_ulcer after one week 's treatment with omeprazole and rabeprazole in relation to CYP2C19 genotype .
18214455	0	omeprazole	34,44	CYP2C19	62,69	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	sulfoxidation|amod|START_ENTITY sulfoxidation|nmod|PMs PMs|compound|END_ENTITY	Effects of the CYP3A5 genotype on omeprazole sulfoxidation in CYP2C19 PMs .
18294333	0	omeprazole	10,20	CYP2C19	51,58	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|nmod|carriers carriers|nmod|END_ENTITY	Increased omeprazole metabolism in carriers of the CYP2C19 * 17 allele ; a pharmacokinetic study in healthy volunteers .
18654768	0	omeprazole	12,22	CYP2C19	59,66	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	Kinetics|nmod|START_ENTITY Kinetics|nmod|relation relation|nmod|END_ENTITY	Kinetics of omeprazole and escitalopram in relation to the CYP2C19 * 17 allele in healthy subjects .
19398604	0	omeprazole	56,66	CYP2C19	78,85	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	START_ENTITY|acl|related related|nmod|polymorphisms polymorphisms|nummod|END_ENTITY	Clopidogrel inhibits CYP2C19-dependent hydroxylation of omeprazole related to CYP2C19 genetic polymorphisms .
19583677	0	omeprazole	76,86	CYP2C19	0,7	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	evaluated|nmod|START_ENTITY activity|acl|evaluated marker|nmod|activity haplotypes|nmod|marker haplotypes|nsubj|END_ENTITY	CYP2C19 haplotypes in Koreans as a marker of enzyme activity evaluated with omeprazole .
20223877	0	omeprazole	59,69	CYP2C19	14,21	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY allele|nmod|pharmacokinetics Impact|dep|allele Impact|nmod|END_ENTITY	Impact of the CYP2C19 * 17 allele on the pharmacokinetics of omeprazole and pantoprazole in children : evidence for a differential effect .
20414645	0	omeprazole	89,99	CYP2C19	13,20	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of CYP2C19 on the relationship between pharmacokinetics and intragastric pH of omeprazole administered by successive intravenous infusions in Chinese healthy volunteers .
21783435	0	omeprazole	16,26	CYP2C19	96,103	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	assay|nmod|START_ENTITY related|nsubj|assay related|nmod|genotypes genotypes|nummod|END_ENTITY	Chiral assay of omeprazole and metabolites and its application to a pharmacokinetics related to CYP2C19 genotypes .
21783435	5	omeprazole	1290,1300	CYP2C19	1336,1343	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	study|nmod|START_ENTITY applied|nmod|study applied|nmod|genotypes genotypes|compound|END_ENTITY	The present method was successfully applied to a chiral pharmacokinetic study of omeprazole in human volunteers with different CYP2C19 genotypes .
21795468	0	omeprazole	27,37	CYP2C19	116,123	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|nsubj|inhibitor inhibitor|nmod|END_ENTITY	The proton pump inhibitor , omeprazole , but not lansoprazole or pantoprazole , is a metabolism-dependent inhibitor of CYP2C19 : implications for coadministration with clopidogrel .
22004687	0	omeprazole	11,21	CYP2C19	50,57	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	polymorphism|amod|START_ENTITY Effects|nmod|polymorphism Effects|nmod|END_ENTITY	Effects of omeprazole and genetic polymorphism of CYP2C19 on the clopidogrel active metabolite .
22875511	0	omeprazole	33,43	CYP2C19	114,121	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	pump|dobj|START_ENTITY pump|nmod|effect effect|nmod|clopidogrel clopidogrel|nmod|individuals individuals|nmod|END_ENTITY	-LSB- Impact of proton pump inhibitor omeprazole on the antiplatelet effect of clopidogrel in individuals with various CYP2C19 * 2 genotypes -RSB- .
23046071	0	omeprazole	17,27	CYP2C19	77,84	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	influence|nmod|START_ENTITY influence|nmod|alleles alleles|amod|clopidogrel clopidogrel|nmod|END_ENTITY	The influence of omeprazole on platelet inhibition of clopidogrel in various CYP2C19 mutant alleles .
23620487	0	omeprazole	36,46	CYP2C19	14,21	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	metabolites|amod|START_ENTITY Inhibition|nmod|metabolites Inhibition|nmod|END_ENTITY	Inhibition of CYP2C19 and CYP3A4 by omeprazole metabolites and their contribution to drug-drug interactions .
23629159	0	omeprazole	32,42	CYP2C19	57,64	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	metabolism|amod|START_ENTITY induction|nmod|metabolism dependent|nsubj|induction dependent|nmod:npmod|genotype genotype|nummod|END_ENTITY	Efavirenz-mediated induction of omeprazole metabolism is CYP2C19 genotype dependent .
24246616	1	omeprazole	196,206	CYP2C19	300,307	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	inhibitors|amod|START_ENTITY interact|nsubj|inhibitors interact|advcl|inhibiting inhibiting|dobj|formation formation|nmod|metabolite metabolite|nmod|inhibition inhibition|compound|END_ENTITY	BACKGROUND : Several studies have suggested that proton-pump inhibitors -LRB- PPIs -RRB- , mostly omeprazole , interact with clopidogrel efficacy by inhibiting the formation of its active metabolite via CYP2C19 inhibition .
24761684	0	omeprazole	76,86	CYP2C19	174,181	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	using|dobj|START_ENTITY using|nmod|polymorphism polymorphism|compound|END_ENTITY	Modified sequential Helicobacter_pylori eradication therapy using high dose omeprazole and amoxicillin in the initial phase in the extensive metaboliser Turkish patients for CYP2C19 polymorphism is ineffective .
7669487	0	omeprazole	101,111	CYP2C19	127,134	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	START_ENTITY|nmod|probe probe|nmod|END_ENTITY	Interphenotype differences in disposition and effect on gastrin levels of omeprazole -- suitability of omeprazole as a probe for CYP2C19 .
7669487	0	omeprazole	74,84	CYP2C19	127,134	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	levels|nmod|START_ENTITY differences|nmod|levels differences|dep|suitability suitability|nmod|omeprazole omeprazole|nmod|probe probe|nmod|END_ENTITY	Interphenotype differences in disposition and effect on gastrin levels of omeprazole -- suitability of omeprazole as a probe for CYP2C19 .
8675169	0	omeprazole	35,45	CYP2C19	91,98	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	START_ENTITY|acl|caused caused|nmod|saturation saturation|nmod|END_ENTITY	Nonlinear kinetics after high-dose omeprazole caused by saturation of genetically variable CYP2C19 .
8681489	0	omeprazole	20,30	CYP2C19	47,54	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	START_ENTITY|dep|substrate substrate|nmod|END_ENTITY	Pharmacokinetics of omeprazole -LRB- a substrate of CYP2C19 -RRB- and comparison with two mutant alleles , C gamma P2C19m1 in exon 5 and C gamma P2C19m2 in exon 4 , in Japanese subjects .
8747407	0	omeprazole	7,17	CYP2C19	38,45	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	START_ENTITY|nmod|drug drug|nmod|phenotype phenotype|nummod|END_ENTITY	Use of omeprazole as a probe drug for CYP2C19 phenotype in Swedish Caucasians : comparison with S-mephenytoin hydroxylation phenotype and CYP2C19 genotype .
8823231	0	omeprazole	59,69	CYP2C19	17,24	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	Americans|nmod|START_ENTITY phenotype|nmod|Americans phenotype|nummod|END_ENTITY	Determination of CYP2C19 phenotype in black Americans with omeprazole : correlation with genotype .
8894508	0	omeprazole	25,35	CYP2C19	6,13	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	5-hydroxylase|compound|START_ENTITY 5-hydroxylase|nsubj|END_ENTITY	Human CYP2C19 is a major omeprazole 5-hydroxylase , as demonstrated with recombinant cytochrome_P450 enzymes .
9014204	0	omeprazole	45,55	CYP2C19	0,7	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	determined|nmod|START_ENTITY determined|nsubj|END_ENTITY	CYP2C19 genotype and phenotype determined by omeprazole in a Korean population .
9284848	0	omeprazole	34,44	CYP2C19	58,65	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	hydroxylation|nmod|START_ENTITY catalyzed|nsubj|hydroxylation catalyzed|nmod|END_ENTITY	Enantioselective hydroxylation of omeprazole catalyzed by CYP2C19 in Swedish white subjects .
9829356	0	omeprazole	47,57	CYP2C19	0,7	omeprazole	CYP2C19	MESH:D009853	1557	Chemical	Gene	determined|nmod|START_ENTITY determined|nsubj|END_ENTITY	CYP2C19 genotype and phenotype determined with omeprazole in patients with acid-related disorders with and without Helicobacter_pylori_infection .
26159874	0	omeprazole	84,94	Cytochrome_P450_2C19	0,20	omeprazole	Cytochrome P450 2C19	MESH:D009853	1557	Chemical	Gene	inhibitors|amod|START_ENTITY phenoconversion|nmod|inhibitors phenoconversion|amod|END_ENTITY	Cytochrome_P450_2C19 phenoconversion by routinely prescribed proton pump inhibitors omeprazole and esomeprazole : clinical implications for personalized medicine .
24145087	0	omeprazole	15,25	GLP-1	31,36	omeprazole	GLP-1	MESH:D009853	14526(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|therapy therapy|compound|END_ENTITY	Combination of omeprazole with GLP-1 agonist therapy improves insulin sensitivity and antioxidant activity in liver in type 1 diabetic mice .
24048734	0	omeprazole	66,76	IL-8	86,90	omeprazole	IL-8	MESH:D009853	3576	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	In oesophageal squamous cells exposed to acidic bile_salt medium , omeprazole inhibits IL-8 expression through effects on nuclear factor-kB and activator protein-1 .
16438963	0	omeprazole	23,33	Proton_pump	0,11	omeprazole	Proton pump	MESH:D009853	495	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Proton_pump inhibitors omeprazole and lansoprazole induce relaxation of isolated human arteries .
25223993	0	omeprazole	81,91	Triosephosphate_Isomerase	9,34	omeprazole	Triosephosphate Isomerase	MESH:D009853	7167	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nmod|effect	Giardial Triosephosphate_Isomerase as possible target of the cytotoxic effect of omeprazole in Giardia .
15012614	0	omeprazole	77,87	chromogranin_A	97,111	omeprazole	chromogranin A	MESH:D009853	1113	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Effect of short-term treatment with low dosages of the proton-pump inhibitor omeprazole on serum chromogranin_A levels in man .
1505152	0	omeprazole	43,53	cytochrome_P450IA2	12,30	omeprazole	cytochrome P450IA2	MESH:D009853	1544	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Increase of cytochrome_P450IA2 activity by omeprazole : evidence by the 13C - -LSB- N-3-methyl -RSB- - caffeine breath test in poor and extensive metabolizers of S-mephenytoin .
12189366	0	omeprazole	78,88	cytochrome_P450_2C19	43,63	omeprazole	cytochrome P450 2C19	MESH:D009853	1557	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Effect of sex and menstrual cycle phase on cytochrome_P450_2C19 activity with omeprazole used as a biomarker .
19385713	0	omeprazole	45,55	cytochrome_P450_2C19	14,34	omeprazole	cytochrome P450 2C19	MESH:D009853	1557	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|inhibitor inhibitor|amod|END_ENTITY	Effect of the cytochrome_P450_2C19 inhibitor omeprazole on the pharmacokinetics and safety profile of bortezomib in patients with advanced solid tumours , non-Hodgkin 's _ lymphoma or multiple_myeloma .
20804307	0	omeprazole	82,92	cytochrome_P450_2C19	8,28	omeprazole	cytochrome P450 2C19	MESH:D009853	1557	Chemical	Gene	efficacy|nmod|START_ENTITY polymorphisms|nmod|efficacy polymorphisms|amod|END_ENTITY	Role of cytochrome_P450_2C19 genetic polymorphisms in the therapeutic efficacy of omeprazole in Iranian patients with erosive reflux_esophagitis .
8647857	0	omeprazole	97,107	cytochrome_P450_2C19	53,73	omeprazole	cytochrome P450 2C19	MESH:D009853	1557	Chemical	Gene	activity|amod|START_ENTITY determinants|nmod|activity END_ENTITY|nmod|determinants	Identification of residues 99 , 220 , and 221 of human cytochrome_P450_2C19 as key determinants of omeprazole activity .
9353355	0	omeprazole	76,86	cytochrome_P450_2C19	27,47	omeprazole	cytochrome P450 2C19	MESH:D009853	1557	Chemical	Gene	oxidation|nmod|START_ENTITY contributions|nmod|oxidation contributions|nmod|END_ENTITY	Different contributions of cytochrome_P450_2C19 and 3A4 in the oxidation of omeprazole by human liver microsomes : effects of contents of these two forms in individual human samples .
11943947	0	omeprazole	11,21	fibroblast_growth_factor-2	40,66	omeprazole	fibroblast growth factor-2	MESH:D009853	2247	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of omeprazole and famotidine on fibroblast_growth_factor-2 during artificial gastric_ulcer_healing in humans .
10027653	0	omeprazole	83,93	gastrin	40,47	omeprazole	gastrin	MESH:D009853	2520	Chemical	Gene	treatment|amod|START_ENTITY concentrations|nmod|treatment concentrations|compound|END_ENTITY	Helicobacter_pylori clearance and serum gastrin and pepsinogen_I concentrations in omeprazole treatment of duodenal ulcer patients .
11418787	0	omeprazole	53,63	gastrin	81,88	omeprazole	gastrin	MESH:D009853	2520	Chemical	Gene	therapy|amod|START_ENTITY Effect|nmod|therapy Effect|nmod|END_ENTITY	Effect of long-term , continuous versus alternate-day omeprazole therapy on serum gastrin in patients treated for reflux_esophagitis .
11819697	0	omeprazole	10,20	gastrin	71,78	omeprazole	gastrin	MESH:D009853	2520	Chemical	Gene	therapy|compound|START_ENTITY therapy|dep|follow-up follow-up|nmod|levels levels|compound|END_ENTITY	Long term omeprazole therapy for reflux_esophagitis : follow-up in serum gastrin levels , EC cell hyperplasia and neoplasia .
1355378	0	omeprazole	11,21	gastrin	54,61	omeprazole	gastrin	MESH:D009853	25320(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|number number|nmod|END_ENTITY	Effects of omeprazole on the number of immunoreactive gastrin - and somatostatin-cells in the rat gastric mucosa .
1392017	0	omeprazole	132,142	gastrin	46,53	omeprazole	gastrin	MESH:D009853	2520	Chemical	Gene	effect|nmod|START_ENTITY evidence|nmod|effect observations|dep|evidence observations|nmod|END_ENTITY	Preliminary observations in the fasting serum gastrin in patients with duodenal ulcer ; further evidence of the `` clearing '' effect of omeprazole on H_pylori ?
1397739	0	omeprazole	83,93	gastrin	57,64	omeprazole	gastrin	MESH:D009853	2520	Chemical	Gene	therapy|amod|START_ENTITY END_ENTITY|nmod|therapy	Clinical significance of hypergastrinaemia : relevance to gastrin monitoring during omeprazole therapy .
1459168	0	omeprazole	82,92	gastrin	39,46	omeprazole	gastrin	MESH:D009853	2520	Chemical	Gene	treated|nmod|START_ENTITY patients|acl|treated concentrations|nmod|patients concentrations|nmod|precursor precursor|compound|END_ENTITY	Increased tissue concentrations of the gastrin precursor in patients treated with omeprazole .
1471315	0	omeprazole	11,21	gastrin	47,54	omeprazole	gastrin	MESH:D009853	25320(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|concentration concentration|compound|END_ENTITY	Effects of omeprazole and ranitidine on plasma gastrin concentration and stomach gastrin content in rats .
1561524	0	omeprazole	15,25	gastrin	86,93	omeprazole	gastrin	MESH:D009853	2520	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of omeprazole on interdigestive motility and early postprandial levels of gastrin and secretin .
1841954	0	omeprazole	12,22	gastrin	44,51	omeprazole	gastrin	MESH:D009853	25320(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|depression depression|nmod|cell cell|compound|END_ENTITY	Reversal by omeprazole of the depression of gastrin cell function by fasting in the rat .
1981116	0	omeprazole	10,20	gastrin	30,37	omeprazole	gastrin	MESH:D009853	2520	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Effect of omeprazole on serum gastrin levels : influence of age and sex .
2104080	0	omeprazole	38,48	gastrin	6,13	omeprazole	gastrin	MESH:D009853	2520	Chemical	Gene	treatment|compound|START_ENTITY Serum|nmod|treatment Serum|dobj|levels levels|compound|END_ENTITY	Serum gastrin levels during long-term omeprazole treatment .
2199288	0	omeprazole	35,45	gastrin	55,62	omeprazole	gastrin	MESH:D009853	2520	Chemical	Gene	treatment|nmod|START_ENTITY Effect|nmod|treatment Effect|nmod|END_ENTITY	Effect of long-term treatment with omeprazole on serum gastrin and serum group A and C pepsinogens in patients with reflux_esophagitis .
2227275	0	omeprazole	54,64	gastrin	40,47	omeprazole	gastrin	MESH:D009853	2520	Chemical	Gene	treatment|amod|START_ENTITY END_ENTITY|nmod|treatment	24-hour intragastric acidity and plasma gastrin after omeprazole treatment and after proximal gastric vagotomy in duodenal ulcer patients .
2570728	0	omeprazole	49,59	gastrin	76,83	omeprazole	gastrin	MESH:D009853	100685087	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nmod|release release|compound|END_ENTITY	Effect of acute suppression of acid secretion by omeprazole on postprandial gastrin release in conscious dogs .
2598968	0	omeprazole	21,31	gastrin	97,104	omeprazole	gastrin	MESH:D009853	2520	Chemical	Gene	administration|compound|START_ENTITY Effect|nmod|administration pepsinogens|nsubj|Effect pepsinogens|nmod|END_ENTITY	Effect of short-term omeprazole administration on serum pepsinogens in relation to fasting serum gastrin and gastric_acid secretion .
3220312	0	omeprazole	33,43	gastrin	102,109	omeprazole	gastrin	MESH:D009853	2520	Chemical	Gene	therapy|nmod|START_ENTITY Effect|nmod|therapy Effect|nmod|END_ENTITY	Effect of ` weekend therapy ' with omeprazole on basal and stimulated acid secretion and fasting plasma gastrin in duodenal ulcer patients .
3378386	0	omeprazole	44,54	gastrin	87,94	omeprazole	gastrin	MESH:D009853	2520	Chemical	Gene	therapy|nmod|START_ENTITY Effect|nmod|therapy Effect|nmod|concentrations concentrations|compound|END_ENTITY	Effect of intermittent weekend therapy with omeprazole on basal and postprandial serum gastrin concentrations in patients with duodenal ulcer .
7657043	0	omeprazole	18,28	gastrin	88,95	omeprazole	gastrin	MESH:D009853	25320(Tax:10116)	Chemical	Gene	year|amod|START_ENTITY Administration|nmod|year produces|nsubj|Administration produces|dobj|effects effects|nmod|END_ENTITY	Administration of omeprazole to rats for one year produces reciprocal effects on antral gastrin and somatostatin cells and no effect on endocrine cells in the colon .
7669487	0	omeprazole	101,111	gastrin	56,63	omeprazole	gastrin	MESH:D009853	2520	Chemical	Gene	suitability|nmod|START_ENTITY differences|dep|suitability differences|nmod|levels levels|compound|END_ENTITY	Interphenotype differences in disposition and effect on gastrin levels of omeprazole -- suitability of omeprazole as a probe for CYP2C19 .
7669487	0	omeprazole	74,84	gastrin	56,63	omeprazole	gastrin	MESH:D009853	2520	Chemical	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	Interphenotype differences in disposition and effect on gastrin levels of omeprazole -- suitability of omeprazole as a probe for CYP2C19 .
7951847	0	omeprazole	49,59	gastrin	6,13	omeprazole	gastrin	MESH:D009853	2520	Chemical	Gene	administration|nmod|START_ENTITY levels|nmod|administration levels|compound|END_ENTITY	Serum gastrin levels following administration of omeprazole alone or in combination with pirenzepine .
8038355	0	omeprazole	107,117	gastrin	29,36	omeprazole	gastrin	MESH:D009853	2520	Chemical	Gene	treatment|nmod|START_ENTITY patients|nmod|treatment Effect|nmod|patients Effect|nmod|END_ENTITY	Effect of enprostil on serum gastrin and pepsinogen A and C levels in patients on long-term treatment with omeprazole .
8116940	0	omeprazole	54,64	gastrin	110,117	omeprazole	gastrin	MESH:D009853	100034214(Tax:9796)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|concentration concentration|compound|END_ENTITY	Effects of single intravenously administered doses of omeprazole and ranitidine on intragastric_pH and plasma gastrin concentration in nonfed ponies .
8281719	0	omeprazole	11,21	gastrin	58,65	omeprazole	gastrin	MESH:D009853	2520	Chemical	Gene	therapy|amod|START_ENTITY Effects|nmod|therapy Effects|nmod|levels levels|compound|END_ENTITY	Effects of omeprazole therapy on peptic_disease and serum gastrin levels in hemodialysis patients .
8359554	0	omeprazole	39,49	gastrin	59,66	omeprazole	gastrin	MESH:D009853	2520	Chemical	Gene	administration|nmod|START_ENTITY Effect|nmod|administration Effect|nmod|END_ENTITY	Effect of short-term administration of omeprazole on serum gastrin and pepsinogens in antrectomized patients .
8482449	0	omeprazole	10,20	gastrin	54,61	omeprazole	gastrin	MESH:D009853	2520	Chemical	Gene	therapy|compound|START_ENTITY therapy|dep|END_ENTITY	Long-term omeprazole therapy in peptic ulcer disease : gastrin , endocrine cell growth , and gastritis .
8580270	0	omeprazole	10,20	gastrin	43,50	omeprazole	gastrin	MESH:D009853	2520	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of omeprazole and feeding on plasma gastrin in patients with achlorhydria .
9248855	0	omeprazole	51,61	gastrin	15,22	omeprazole	gastrin	MESH:D009853	25320(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY induced|nmod|treatment induced|nsubj|Alterations Alterations|nmod|cells cells|compound|END_ENTITY	Alterations in gastrin cells induced by short-term omeprazole treatment in the rat antrum : an immunocytochemical and in situ hybridization study .
2518851	0	omeprazole	28,38	intrinsic_factor	53,69	omeprazole	intrinsic factor	MESH:D009853	2694	Chemical	Gene	doses|nmod|START_ENTITY affect|nsubj|doses affect|dobj|secretion secretion|compound|END_ENTITY	Repeated high oral doses of omeprazole do not affect intrinsic_factor secretion : proof of a selective mode of action .
3924748	0	omeprazole	10,20	intrinsic_factor	41,57	omeprazole	intrinsic factor	MESH:D009853	2694	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|nmod|END_ENTITY	Effect of omeprazole on the secretion of intrinsic_factor , gastric_acid and pepsin in man .
8871451	0	omeprazole	15,25	mucin	44,49	omeprazole	mucin	MESH:D009853	65202(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|release release|compound|END_ENTITY	The effects of omeprazole and famotidine on mucin and PGE2 release in the rat stomach .
12538803	0	omeprazole	13,23	multidrug_resistance_protein_3	27,57	omeprazole	multidrug resistance protein 3	MESH:D009853	5244	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|expression expression|amod|END_ENTITY	Influence of omeprazole on multidrug_resistance_protein_3 expression in human liver .
2996557	0	omeprazole	17,27	pepsinogen	62,72	omeprazole	pepsinogen	MESH:D009853	100328625(Tax:9986)	Chemical	Gene	START_ENTITY|nmod|synthesis synthesis|nmod|END_ENTITY	The influence of omeprazole on the synthesis and secretion of pepsinogen in isolated rabbit gastric glands .
26472491	0	onabotulinumtoxinA	62,80	SNAP-25	22,29	onabotulinumtoxinA	SNAP-25	MESH:C542870	20614(Tax:10090)	Chemical	Gene	injection|nmod|START_ENTITY END_ENTITY|nmod|injection	Expression of cleaved SNAP-25 after bladder wall injection of onabotulinumtoxinA or abobotulinumtoxinA : A comparative study in the mice .
23321066	6	ondansetron	1079,1090	5-HT3A	1109,1115	ondansetron	5-HT3A	MESH:D017294	3359	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|nmod|END_ENTITY	Furthermore , the ion-channel activity of the reconstituted P9-5-HT3A was effectively blocked by treatment with ondansetron , an antagonist of 5-HT3A .
1407694	0	ondansetron	40,51	5-HT3_receptor	14,28	ondansetron	5-HT3 receptor	MESH:D017294	79246(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|antagonist antagonist|amod|END_ENTITY	Effect of the 5-HT3_receptor antagonist ondansetron on hypothalamic self-stimulation in rats and its interaction with the CCK analogue caerulein .
7597126	0	ondansetron	168,179	5-HT3_receptor	141,155	ondansetron	5-HT3 receptor	MESH:D017294	79246(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Reversal_of_visual_attentional_dysfunction following lesions of the cholinergic basal forebrain by physostigmine and nicotine but not by the 5-HT3_receptor antagonist , ondansetron .
8799580	0	ondansetron	45,56	5-HT3_receptor	18,32	ondansetron	5-HT3 receptor	MESH:D017294	79246(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Prevention by the 5-HT3_receptor antagonist , ondansetron , of morphine-dependence and tolerance in the rat .
9498729	0	ondansetron	61,72	5-HT3_receptor	76,90	ondansetron	5-HT3 receptor	MESH:D017294	79246(Tax:10116)	Chemical	Gene	Blockade|nmod|START_ENTITY Blockade|appos|antagonist antagonist|amod|END_ENTITY	Blockade of the expression of sensitization and tolerance by ondansetron , a 5-HT3_receptor antagonist , administered during withdrawal from intermittent and continuous cocaine .
9932709	0	ondansetron	56,67	5-HT3_receptor	22,36	ondansetron	5-HT3 receptor	MESH:D017294	79246(Tax:10116)	Chemical	Gene	down-regulation|nmod|START_ENTITY down-regulation|amod|END_ENTITY	Blockade of accumbens 5-HT3_receptor down-regulation by ondansetron administered during continuous cocaine administration .
8856622	0	ondansetron	42,53	5-hydroxytryptamine_type_3_receptor	55,90	ondansetron	5-hydroxytryptamine type 3 receptor	MESH:D017294	3359	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Pathogenetic aspects of responsiveness to ondansetron -LRB- 5-hydroxytryptamine_type_3_receptor antagonist -RRB- in patients with primary_fibromyalgia syndrome -- a preliminary study .
26338742	0	ondansetron	69,80	ABCB1	35,40	ondansetron	ABCB1	MESH:D017294	5243	Chemical	Gene	efficacy|nmod|START_ENTITY END_ENTITY|nmod|efficacy	Influence of genetic variations in ABCB1 on the clinical efficacy of ondansetron - A pharmacogenetic analysis of Pakistani population .
21596874	0	ondansetron	70,81	CYP2D6	0,6	ondansetron	CYP2D6	MESH:D017294	1565	Chemical	Gene	concentrations|nmod|START_ENTITY concentrations|amod|END_ENTITY	CYP2D6 - and CYP3A-dependent enantioselective plasma concentrations of ondansetron in postanesthesia care .
21840870	0	ondansetron	76,87	CYP2D6	42,48	ondansetron	CYP2D6	MESH:D017294	1565	Chemical	Gene	response|amod|START_ENTITY polymorphisms|nmod|response polymorphisms|nummod|END_ENTITY	Association of ABCB1 , 5-HT3B receptor and CYP2D6 genetic polymorphisms with ondansetron and metoclopramide antiemetic response in Indonesian cancer patients treated with highly emetogenic chemotherapy .
20201779	0	ondansetron	17,28	CYP3A4	85,91	ondansetron	CYP3A4	MESH:D017294	1576	Chemical	Gene	interactions|amod|START_ENTITY interactions|nmod|END_ENTITY	An evaluation of ondansetron binding interactions with human cytochrome P450 enzymes CYP3A4 and CYP2D6 .
17456656	0	ondansetron	80,91	NK1	45,48	ondansetron	NK1	MESH:D017294	6869	Chemical	Gene	comparison|nmod|START_ENTITY comparison|nmod|END_ENTITY	A randomized , double-blind comparison of the NK1 antagonist , aprepitant , versus ondansetron for the prevention of postoperative_nausea_and_vomiting .
8804550	0	ondansetron	14,25	acetylcholinesterase	58,78	ondansetron	acetylcholinesterase	MESH:D017294	100422792	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nsubj|effect	The effect of ondansetron on pyridostigmine-induced blood acetylcholinesterase inhibition in the guinea_pig .
16664047	0	ophiobolin_a	55,67	calmodulin	8,18	ophiobolin a	calmodulin	MESH:C040764	542465(Tax:4577)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|inhibition inhibition|compound|END_ENTITY	Role of calmodulin inhibition in the mode of action of ophiobolin_a .
23248072	0	opicapone	55,64	catechol-O-methyltransferase	74,102	opicapone	catechol-O-methyltransferase	MESH:C549349	1312	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Pharmacokinetics , pharmacodynamics and tolerability of opicapone , a novel catechol-O-methyltransferase inhibitor , in healthy subjects : prediction of slow enzyme-inhibitor complex dissociation of a short-living and very long-acting inhibitor .
25649051	0	opicapone	10,19	catechol-O-methyltransferase	50,78	opicapone	catechol-O-methyltransferase	MESH:C549349	1312	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|pharmacokinetics pharmacokinetics|appos|activity activity|amod|END_ENTITY	Effect of opicapone on levodopa pharmacokinetics , catechol-O-methyltransferase activity and motor fluctuations in patients with Parkinson 's _ disease .
26408375	0	oral_contraceptives	10,29	MMP-2	61,66	oral contraceptives	MMP-2	MESH:D003276	4313	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of oral_contraceptives and doxycycline on endometrial MMP-2 and MMP-9 activity .
11702580	0	orexin	13,19	Hypocretin	1,11	orexin	Hypocretin	MESH:C110857	15171(Tax:10090)	Chemical	Gene	_|appos|START_ENTITY _|compound|END_ENTITY	-LSB- Hypocretin _ -LRB- orexin -RRB- _ deficiency in narcolepsy-cataplexy -RSB- .
21873816	0	organochlorine	31,45	PCB	26,29	organochlorine	PCB	null	5091	Chemical	Gene	START_ENTITY|nsubj|analysis analysis|nmod|END_ENTITY	-LSB- Multiresidue analysis of PCB , organochlorine pesticides and chlordanes in marine products by GC-micro ECD -RSB- .
22829064	0	organochlorines	43,58	Estrogen_receptor_alpha	0,23	organochlorines	Estrogen receptor alpha	null	2099	Chemical	Gene	target|nmod|START_ENTITY END_ENTITY|nmod|target	Estrogen_receptor_alpha as a key target of organochlorines to promote angiogenesis .
21126941	0	organophosphate	73,88	PON1	0,4	organophosphate	PON1	null	5444	Chemical	Gene	exposed|xcomp|START_ENTITY exposed|nsubj|END_ENTITY	PON1 and neurodevelopment in children from the CHAMACOS study exposed to organophosphate pesticides in utero .
10869390	0	organophosphate	54,69	acetylcholinesterase	100,120	organophosphate	acetylcholinesterase	null	11423(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|acl|lacking lacking|dobj|END_ENTITY	Postnatal_developmental_delay and supersensitivity to organophosphate in gene-targeted mice lacking acetylcholinesterase .
2340283	0	organophosphate	18,33	acetylcholinesterase	60,80	organophosphate	acetylcholinesterase	null	11423(Tax:10090)	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of an organophosphate with a peripheral site on acetylcholinesterase .
7376900	0	organophosphate	75,90	acetylcholinesterase	46,66	organophosphate	acetylcholinesterase	null	11423(Tax:10090)	Chemical	Gene	inhibition|amod|START_ENTITY END_ENTITY|nmod|inhibition	Protective effect of some pyridinium_salts on acetylcholinesterase against organophosphate inhibition .
21864557	0	organophosphate	32,47	paraoxonase_1	8,21	organophosphate	paraoxonase 1	null	5444	Chemical	Gene	metabolism|amod|START_ENTITY END_ENTITY|nmod|metabolism	Role of paraoxonase_1 -LRB- PON1 -RRB- in organophosphate metabolism : implications in neurodegenerative_diseases .
7737042	0	organophosphate_esters	90,112	acetylcholinesterase	66,86	organophosphate esters	acetylcholinesterase	CHEBI:25703	83817(Tax:10116)	Chemical	Gene	based|nmod|START_ENTITY based|nmod|inhibition inhibition|nmod|END_ENTITY	Physiologically based pharmacokinetic model for the inhibition of acetylcholinesterase by organophosphate_esters .
22230262	0	organophosphates	24,40	acetylcholinesterase	87,107	organophosphates	acetylcholinesterase	MESH:D010755	43	Chemical	Gene	kinetics|nmod|START_ENTITY END_ENTITY|nsubj|kinetics	Comparative kinetics of organophosphates and oximes with erythrocyte , muscle and brain acetylcholinesterase .
2362084	0	organophosphinates	64,82	acetylcholinesterase	30,50	organophosphinates	acetylcholinesterase	null	43	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubj|reactivation reactivation|nmod|END_ENTITY	Oxime-induced reactivation of acetylcholinesterase inhibited by organophosphinates .
23200223	0	organophosphorous-homodimers	47,75	acetylcholinesterase	97,117	organophosphorous-homodimers	acetylcholinesterase	null	41625(Tax:7227)	Chemical	Gene	evaluation|nmod|START_ENTITY END_ENTITY|nsubj|evaluation	Design , synthesis and biological evaluation of organophosphorous-homodimers as dual binding site acetylcholinesterase inhibitors .
15833035	0	organophosphorus	34,50	acetylcholinesterase	83,103	organophosphorus	acetylcholinesterase	null	43	Chemical	Gene	kinetics|nmod|START_ENTITY kinetics|nmod|END_ENTITY	Reaction kinetics of biotinylated organophosphorus toxicant , FP-biotin , with human acetylcholinesterase and human butyrylcholinesterase .
16485896	0	organophosphorus	79,95	acetylcholinesterase	25,45	organophosphorus	acetylcholinesterase	null	43	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Mechanistic insight into acetylcholinesterase inhibition and acute toxicity of organophosphorus compounds : a molecular modeling study .
20493132	0	organophosphorus	69,85	acetylcholinesterase	100,120	organophosphorus	acetylcholinesterase	null	11423(Tax:10090)	Chemical	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Interaction of a bisquaternary ammonium compound with the peripheral organophosphorus -LRB- POP -RRB- site on acetylcholinesterase .
2854078	0	organophosphorus	87,103	acetylcholinesterase	117,137	organophosphorus	acetylcholinesterase	null	83817(Tax:10116)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|nmod|END_ENTITY	-LSB- Restoration of neuromuscular transmission in the rat diaphragm after the action of an organophosphorus inhibitor of acetylcholinesterase by using curare -RSB- .
3603567	0	organophosphorus	100,116	acetylcholinesterase	131,151	organophosphorus	acetylcholinesterase	null	83817(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|inhibitors inhibitors|nmod|END_ENTITY	Differences in central and peripheral neural actions between soman and diisopropyl_fluorophosphate , organophosphorus inhibitors of acetylcholinesterase .
6300751	0	organophosphorus	34,50	acetylcholinesterase	51,71	organophosphorus	acetylcholinesterase	null	43	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nsubj|effects	Direct and indirect effects of an organophosphorus acetylcholinesterase inhibitor and of an oxime on a neuro-neuronal synapse .
9823777	0	organophosphorus	104,120	neuropathy_target_esterase	45,71	organophosphorus	neuropathy target esterase	null	10908	Chemical	Gene	administration|nmod|START_ENTITY END_ENTITY|nmod|administration	Delayed neuropathy and inhibition of soluble neuropathy_target_esterase following the administration of organophosphorus compounds to hens .
25784934	0	organophosphorus	66,82	paraoxonase	23,34	organophosphorus	paraoxonase	null	5444	Chemical	Gene	hydrolysis|nmod|START_ENTITY hydrolysis|amod|END_ENTITY	Species differences in paraoxonase mediated hydrolysis of several organophosphorus insecticide metabolites .
1679650	0	organophosphorus	14,30	pseudocholinesterase	50,70	organophosphorus	pseudocholinesterase	null	590	Chemical	Gene	effect|nmod|START_ENTITY compounds|nsubj|effect compounds|nmod|levels levels|compound|END_ENTITY	The effect of organophosphorus compounds on serum pseudocholinesterase levels in a group of industrial workers .
19226137	0	organoruthenium	49,64	sterile_20	75,85	organoruthenium	sterile 20	null	8428	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Toward the development of a potent and selective organoruthenium mammalian sterile_20 kinase inhibitor .
8117321	0	organosulfur	47,59	cytochrome_P4502E1	14,32	organosulfur	cytochrome P4502E1	null	25086(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Inhibition of cytochrome_P4502E1 expression by organosulfur compounds allylsulfide , allylmercaptan and allylmethylsulfide in rats .
23416714	0	oridonin	78,86	HSP70_1A	28,36	oridonin	HSP70 1A	MESH:C011959	3303	Chemical	Gene	target|nmod|START_ENTITY END_ENTITY|nmod|target	Chemical proteomics reveals HSP70_1A as a target for the anticancer diterpene oridonin in Jurkat cells .
23228697	0	orlistat	73,81	Carboxylesterase-2	0,18	orlistat	Carboxylesterase-2	MESH:C055122	8824	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Carboxylesterase-2 is a highly sensitive target of the antiobesity agent orlistat with profound implications in the activation of anticancer prodrugs .
24719628	0	orlistat	50,58	Macrocytic_anemia	0,17	orlistat	Macrocytic anemia	MESH:C055122	6948	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|END_ENTITY	Macrocytic_anemia and thrombocytopenia induced by orlistat .
16375203	0	orlistat	14,22	insulin	40,47	orlistat	insulin	MESH:C055122	3630	Chemical	Gene	therapy|amod|START_ENTITY therapy|nmod|level level|compound|END_ENTITY	-LSB- Influence of orlistat therapy on serum insulin level and morphological and functional parameters of peripheral arterial circulation in obese patients -RSB- .
20683173	0	orlistat	37,45	insulin	55,62	orlistat	insulin	MESH:C055122	3630	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	Orlistat and L-carnitine compared to orlistat alone on insulin resistance in obese diabetic patients .
18370719	0	orlistat	10,18	leptin	29,35	orlistat	leptin	MESH:C055122	3952	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|compound|END_ENTITY	Effect of orlistat on plasma leptin levels and risk factors for the metabolic_syndrome .
18846024	0	orlistat	17,25	leptin	48,54	orlistat	leptin	MESH:C055122	3952	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|levels levels|compound|END_ENTITY	Acute effects of orlistat on postprandial serum leptin levels in nondiabetic_obese patients .
24936112	0	orlistat	43,51	leptin	61,67	orlistat	leptin	MESH:C055122	3952	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Effects of a weight-reduction program with orlistat on serum leptin levels in obese women : A 12-week , randomized , placebo-controlled study .
7632666	0	orlistat	31,39	lipase	14,20	orlistat	lipase	MESH:C055122	16891(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|inhibitor inhibitor|amod|END_ENTITY	Effect of the lipase inhibitor orlistat and of dietary lipid on the absorption of radiolabelled triolein , tri-gamma-linolenin and tripalmitin in mice .
8760203	0	orlistat	32,40	lipase	15,21	orlistat	lipase	MESH:C055122	291437(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Effects of the lipase inhibitor orlistat on intake and preference for dietary fat in rats .
8707896	0	ornithine	53,62	Basic_fibroblast_growth_factor	0,30	ornithine	Basic fibroblast growth factor	CHEBI:18257	14173(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Basic_fibroblast_growth_factor selectively regulates ornithine decarboxylase gene expression in malignant H-ras transformed cells .
8344985	0	ornithine	56,65	H-ras	109,114	ornithine	H-ras	CHEBI:18257	15461(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Transforming_growth_factor_beta_1 selectively regulates ornithine decarboxylase gene expression in malignant H-ras transformed fibrosarcoma cell lines .
19937472	0	ornithine	7,16	SPE1	49,53	ornithine	SPE1	CHEBI:18257	853651(Tax:4932)	Chemical	Gene	decarboxylase|compound|START_ENTITY complements|nsubj|decarboxylase complements|dobj|knock-out knock-out|compound|END_ENTITY	Insect ornithine decarboxylase -LRB- ODC -RRB- complements SPE1 knock-out of yeast Saccharomyces_cerevisiae .
7492339	0	ornithine	34,43	SPE1	64,68	ornithine	SPE1	CHEBI:18257	853651(Tax:4932)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A new model for disruption of the ornithine decarboxylase gene , SPE1 , in Saccharomyces_cerevisiae exhibits growth_arrest and genetic instability at the MAT locus .
9392083	0	ornithine	44,53	SPE1	69,73	ornithine	SPE1	CHEBI:18257	853651(Tax:4932)	Chemical	Gene	Isolation|nmod|START_ENTITY Isolation|amod|END_ENTITY	Isolation and sequence of the gene encoding ornithine decarboxylase , SPE1 , from Candida_albicans by complementation of a spe1 delta strain of Saccharomyces_cerevisiae .
8344985	0	ornithine	56,65	Transforming_growth_factor_beta_1	0,33	ornithine	Transforming growth factor beta 1	CHEBI:18257	21803(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Transforming_growth_factor_beta_1 selectively regulates ornithine decarboxylase gene expression in malignant H-ras transformed fibrosarcoma cell lines .
7705341	0	ornithine	37,46	acetyltransferase	47,64	ornithine	acetyltransferase	CHEBI:18257	853237(Tax:4932)	Chemical	Gene	Purification|nmod|START_ENTITY END_ENTITY|nsubj|Purification	Purification and characterization of ornithine acetyltransferase from Saccharomyces_cerevisiae .
21586232	0	ornithine	17,26	antizyme_inhibitor_1	41,61	ornithine	antizyme inhibitor 1	CHEBI:18257	51582	Chemical	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	-LSB- Polymorphism of ornithine decarboxylase antizyme_inhibitor_1 gene is associated with liver_cirrhosis in Chinese hepatitis_B patients -RSB- .
6243092	0	ornithine	42,51	growth_hormone	11,25	ornithine	growth hormone	CHEBI:18257	81668(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY END_ENTITY|nmod|activity	Effects of growth_hormone and glucagon on ornithine decarboxylase activity and adenosine 3 ' ,5 ' - monophosphate levels in isolated rat hepatocytes .
3112133	0	ornithine	90,99	interferon-gamma	70,86	ornithine	interferon-gamma	CHEBI:18257	15978(Tax:10090)	Chemical	Gene	activity|amod|START_ENTITY END_ENTITY|nmod|activity	Time-dependent differential effects of natural and recombinant murine interferon-gamma on ornithine decarboxylase activity of tumor cells .
6282258	0	ornithine	48,57	ornithine_aminotransferase	16,42	ornithine	ornithine aminotransferase	CHEBI:18257	4942	Chemical	Gene	reaction|nmod|START_ENTITY reaction|nmod|END_ENTITY	The reaction of ornithine_aminotransferase with ornithine .
14688243	0	ornithine	91,100	ornithine_decarboxylase	58,81	ornithine	ornithine decarboxylase	CHEBI:18257	4953	Chemical	Gene	limitation|amod|START_ENTITY includes|dobj|limitation includes|nsubj|homeostasis homeostasis|nmod|plants plants|acl|overexpressing overexpressing|dobj|END_ENTITY	Polyamine homeostasis in transgenic plants overexpressing ornithine_decarboxylase includes ornithine limitation .
1872891	0	ornithine	78,87	ornithine_decarboxylase	34,57	ornithine	ornithine decarboxylase	CHEBI:18257	4953	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Regulation Regulation|nmod|1,4-diamines 1,4-diamines|nmod|activity activity|amod|END_ENTITY	Regulation by 1,4-diamines of the ornithine_decarboxylase activity induced by ornithine in perifused tumor cells .
4830542	2	ornithine	70,79	ornithine_decarboxylase	97,120	ornithine	ornithine decarboxylase	CHEBI:18257	4953	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Alpha-methyl - -LRB- plus or minus -RRB- - ornithine , an inhibitor of ornithine_decarboxylase .
7205870	0	ornithine	43,52	ornithine_decarboxylase	97,120	ornithine	ornithine decarboxylase	CHEBI:18257	4953	Chemical	Gene	analogues|nmod|START_ENTITY analogues|nmod|END_ENTITY	alpha-Ethynyl and alpha-vinyl analogues of ornithine as enzyme-activated inhibitors of mammalian ornithine_decarboxylase .
8845305	0	ornithine	12,21	ornithine_decarboxylase	98,121	ornithine	ornithine decarboxylase	CHEBI:18257	4953	Chemical	Gene	START_ENTITY|nmod|accumulation accumulation|nmod|death death|nmod|cells cells|amod|END_ENTITY	Exposure to ornithine results in excessive accumulation of putrescine and apoptotic cell death in ornithine_decarboxylase overproducing mouse myeloma cells .
7205129	0	ornithine	15,24	placental_lactogen	34,52	ornithine	placental lactogen	CHEBI:18257	443319(Tax:9940)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Stimulation by ornithine of ovine placental_lactogen secretion .
9392083	0	ornithine	44,53	spe1	121,125	ornithine	spe1	CHEBI:18257	853651(Tax:4932)	Chemical	Gene	Isolation|nmod|START_ENTITY Isolation|nmod|strain strain|amod|END_ENTITY	Isolation and sequence of the gene encoding ornithine decarboxylase , SPE1 , from Candida_albicans by complementation of a spe1 delta strain of Saccharomyces_cerevisiae .
3216774	0	ornithine	10,19	transferrin	23,34	ornithine	transferrin	CHEBI:18257	24825(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of ornithine on transferrin secretion of rat and human hepatocyte cultures .
486688	0	ornithine_alphaketoglutarate	11,39	insulin	49,56	ornithine alphaketoglutarate	insulin	null	3630	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of ornithine_alphaketoglutarate on blood insulin , glucagon and aminoacids in alcoholic_cirrhosis .
8174277	1	ornithine_carbamoyl	280,299	OCT	313,316	ornithine carbamoyl	OCT	null	5009	Chemical	Gene	deficiency|amod|START_ENTITY deficiency|appos|END_ENTITY	The increase in orotidine excretion following a 300 mg allopurinol dose has been used for carrier detection in ornithine_carbamoyl transferase -LRB- OCT -RRB- deficiency .
21350910	0	orotate	61,68	urate_transporter_1	6,25	orotate	urate transporter 1	CHEBI:30839	116085	Chemical	Gene	transport|nmod|START_ENTITY mediates|dobj|transport mediates|nsubj|END_ENTITY	Human urate_transporter_1 -LRB- hURAT1 -RRB- mediates the transport of orotate .
15670589	0	orotic_acid	121,132	CYP4A	44,49	orotic acid	CYP4A	MESH:D009963	13117(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|upregulation upregulation|nmod|END_ENTITY	Pretranslational upregulation of microsomal CYP4A in rat liver by intake of a high-sucrose , lipid-devoid diet containing orotic_acid .
22863860	0	orotic_acid	24,35	mTORC1	44,50	orotic acid	mTORC1	MESH:D009963	382056(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Proliferating effect of orotic_acid through mTORC1 activation mediated by negative regulation of AMPK in SK-Hep1 hepatocellular carcinoma cells .
23236370	0	oroxylin_a	15,25	STAT1	0,5	oroxylin a	STAT1	MESH:C080669	6772	Chemical	Gene	inhibition|compound|START_ENTITY mediates|dobj|inhibition mediates|nsubj|END_ENTITY	STAT1 mediates oroxylin_a inhibition of iNOS and pro-inflammatory cytokines expression in microglial BV-2 cells .
23236370	0	oroxylin_a	15,25	iNOS	40,44	oroxylin a	iNOS	MESH:C080669	4843	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	STAT1 mediates oroxylin_a inhibition of iNOS and pro-inflammatory cytokines expression in microglial BV-2 cells .
4746448	0	orphenadrine	13,25	HC1	26,29	orphenadrine	HC1	MESH:D009966	387397(Tax:10116)	Chemical	Gene	Influence|nmod|START_ENTITY END_ENTITY|nsubj|Influence	Influence of orphenadrine HC1 and its N-demethylated derivatives on the in vitro uptake of noradrenaline and 5-hydroxytryptamine by rat brain slices .
17965852	0	orphenadrine	35,47	HERG	57,61	orphenadrine	HERG	MESH:D009966	3757	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Anticholinergic antiparkinson drug orphenadrine inhibits HERG channels : block attenuation by mutations of the pore residues Y652 or F656 .
23856460	0	orteronel	48,57	CYP17A1	29,36	orteronel	CYP17A1	MESH:C571806	25146(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Effect of an investigational CYP17A1 inhibitor , orteronel -LRB- TAK-700 -RRB- , on estrogen - and corticoid-synthesis pathways in hypophysectomized female rats and on the serum estradiol levels in female cynomolgus_monkeys .
20576578	0	ortho-Substituted_C-aryl_glucosides	0,35	sodium-dependent_glucose_co-transporter_2	73,114	ortho-Substituted C-aryl glucosides	sodium-dependent glucose co-transporter 2	null	6524	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	ortho-Substituted_C-aryl_glucosides as highly potent and selective renal sodium-dependent_glucose_co-transporter_2 -LRB- SGLT2 -RRB- inhibitors .
22695972	0	ortho-chlorinated_benzamides	24,52	C-Cl	0,4	ortho-chlorinated benzamides	C-Cl	null	1420	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	C-Cl bond activation of ortho-chlorinated_benzamides by nickel and cobalt compounds supported with phosphine ligands .
4096894	0	ortho-substituted_arylhydrazines	29,61	myoglobin	16,25	ortho-substituted arylhydrazines	myoglobin	null	4151	Chemical	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of myoglobin by ortho-substituted_arylhydrazines .
159076	0	orthophosphate	11,25	ATPase	40,46	orthophosphate	ATPase	MESH:D010710	3654511(Tax:562)	Chemical	Gene	START_ENTITY|dobj|regulation regulation|nmod|activity activity|amod|END_ENTITY	-LSB- Exogenous orthophosphate regulation of ATPase activity of E. _ coli cells -RSB- .
14672816	0	oseltamivir	25,36	GM1	44,47	oseltamivir	GM1	MESH:D053139	210582(Tax:10090)	Chemical	Gene	blocks|compound|START_ENTITY blocks|dep|hyperalgesia hyperalgesia|nummod|END_ENTITY	Neuraminidase inhibitor , oseltamivir blocks GM1 ganglioside-regulated excitatory opioid receptor-mediated hyperalgesia , enhances opioid_analgesia_and_attenuates_tolerance in mice .
19133796	0	oseltamivir	41,52	Neuraminidase	0,13	oseltamivir	Neuraminidase	MESH:D053139	4758	Chemical	Gene	treatment|compound|START_ENTITY END_ENTITY|nmod|treatment	Neuraminidase inhibitor resistance after oseltamivir treatment of acute influenza A and B in children .
23267831	0	oseltamivir	155,166	Neuraminidase	0,13	oseltamivir	Neuraminidase	MESH:D053139	4758	Chemical	Gene	susceptibility|nmod|START_ENTITY identifies|nmod|susceptibility identifies|nsubj|testing testing|amod|END_ENTITY	Neuraminidase inhibitor susceptibility testing of influenza_type_B viruses in China during 2010 and 2011 identifies viruses with reduced susceptibility to oseltamivir and zanamivir .
23776615	0	oseltamivir	44,55	Neuraminidase	5,18	oseltamivir	Neuraminidase	MESH:D053139	4758	Chemical	Gene	susceptibility|compound|START_ENTITY reduce|dobj|susceptibility reduce|nsubj|mutations mutations|compound|END_ENTITY	I222 Neuraminidase mutations further reduce oseltamivir susceptibility of Indonesian Clade 2.1 highly pathogenic Avian Influenza_A -LRB- H5N1 -RRB- _ viruses .
25740997	0	oseltamivir	49,60	Neuraminidase	0,13	oseltamivir	Neuraminidase	MESH:D053139	4758	Chemical	Gene	conferring|advcl|START_ENTITY mutations|acl|conferring mutations|amod|END_ENTITY	Neuraminidase mutations conferring resistance to oseltamivir in influenza_A -LRB- H7N9 -RRB- _ viruses .
22584254	0	oseltamivir	52,63	PEPT1	43,48	oseltamivir	PEPT1	MESH:D053139	117261(Tax:10116)	Chemical	Gene	absorption|compound|START_ENTITY END_ENTITY|nmod|absorption	Role of the intestinal peptide transporter PEPT1 in oseltamivir absorption : in vitro and in vivo studies .
22673926	0	oseltamivir	81,92	carboxylesterase_1	14,32	oseltamivir	carboxylesterase 1	MESH:D053139	1066	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY polymorphisms|nmod|pharmacokinetics polymorphisms|nsubj|effect effect|nmod|END_ENTITY	The effect of carboxylesterase_1 -LRB- CES1 -RRB- polymorphisms on the pharmacokinetics of oseltamivir in humans .
10536125	0	oseltamivir	50,61	neuraminidase	26,39	oseltamivir	neuraminidase	MESH:D053139	4758	Chemical	Gene	START_ENTITY|nsubj|Use Use|nmod|inhibitor inhibitor|compound|END_ENTITY	Use of the selective oral neuraminidase inhibitor oseltamivir to prevent influenza .
12392584	0	oseltamivir	100,111	neuraminidase	68,81	oseltamivir	neuraminidase	MESH:D053139	4758	Chemical	Gene	prodrug|dobj|START_ENTITY inhibitor|xcomp|prodrug inhibitor|nsubj|Lack Lack|nmod|interaction interaction|nmod|END_ENTITY	Lack of pharmacokinetic interaction between the oral anti-influenza neuraminidase inhibitor prodrug oseltamivir and antacids .
17085491	0	oseltamivir	31,42	neuraminidase	56,69	oseltamivir	neuraminidase	MESH:D053139	4758	Chemical	Gene	susceptibility|nmod|START_ENTITY subtype|nmod|susceptibility subtype|nsubj|END_ENTITY	On the lower susceptibility of oseltamivir to influenza neuraminidase subtype N1 than those in N2 and N9 .
17085909	0	oseltamivir	66,77	neuraminidase	42,55	oseltamivir	neuraminidase	MESH:D053139	4758	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Acute hemorrhagic_colitis induced by the neuraminidase inhibitor oseltamivir -RSB- .
17707775	0	oseltamivir	33,44	neuraminidase	66,79	oseltamivir	neuraminidase	MESH:D053139	4758	Chemical	Gene	modifying|dobj|START_ENTITY modifying|advcl|structure structure|compound|END_ENTITY	Analogue inhibitors by modifying oseltamivir based on the crystal neuraminidase structure for treating drug-resistant_H5N1_virus .
18997437	0	oseltamivir	37,48	neuraminidase	12,25	oseltamivir	neuraminidase	MESH:D053139	4758	Chemical	Gene	Effect|appos|START_ENTITY Effect|nmod|inhibitor inhibitor|amod|END_ENTITY	Effect of a neuraminidase inhibitor -LRB- oseltamivir -RRB- on mouse jump-down behavior via stimulation of dopamine receptors .
19046066	0	oseltamivir	65,76	neuraminidase	8,21	oseltamivir	neuraminidase	MESH:D053139	4758	Chemical	Gene	conferring|advcl|START_ENTITY mutation|acl|conferring END_ENTITY|dobj|mutation	A novel neuraminidase deletion mutation conferring resistance to oseltamivir in clinical influenza_A / H3N2_virus .
19397892	0	oseltamivir	80,91	neuraminidase	17,30	oseltamivir	neuraminidase	MESH:D053139	4758	Chemical	Gene	derivatives|compound|START_ENTITY Design|nmod|derivatives using|nsubj|Design Search|parataxis|using Search|nmod|inhibitors inhibitors|compound|END_ENTITY	Search for novel neuraminidase inhibitors : Design , synthesis and interaction of oseltamivir derivatives with model membrane using docking , NMR and DSC methods .
19428595	0	oseltamivir	10,21	neuraminidase	41,54	oseltamivir	neuraminidase	MESH:D053139	4758	Chemical	Gene	Design|nmod|START_ENTITY analogs|nsubj|Design analogs|dobj|END_ENTITY	Design of oseltamivir analogs inhibiting neuraminidase of avian influenza virus H5N1 .
19619898	0	oseltamivir	26,37	neuraminidase	77,90	oseltamivir	neuraminidase	MESH:D053139	4758	Chemical	Gene	effectiveness|nmod|START_ENTITY _|nsubj|effectiveness _|nmod|mutation mutation|amod|END_ENTITY	Clinical effectiveness of oseltamivir for influenza_A -LRB- H1N1 -RRB- _ virus with H274Y neuraminidase mutation .
19857993	0	oseltamivir	122,133	neuraminidase	169,182	oseltamivir	neuraminidase	MESH:D053139	4758	Chemical	Gene	substitution|compound|START_ENTITY _|nmod|substitution _|nmod|END_ENTITY	Evaluation of a rapid molecular algorithm for detection of pandemic influenza_A _ -LRB- H1N1 -RRB- _ 2009_virus and screening for a key oseltamivir resistance -LRB- H275Y -RRB- substitution in neuraminidase .
20100088	0	oseltamivir	68,79	neuraminidase	14,27	oseltamivir	neuraminidase	MESH:D053139	4758	Chemical	Gene	conferring|advcl|START_ENTITY H274Y|acl|conferring H274Y|amod|END_ENTITY	Effect of the neuraminidase mutation H274Y conferring resistance to oseltamivir on the replicative capacity and virulence of old and recent human influenza_A -LRB- H1N1 -RRB- _ viruses .
20368393	0	oseltamivir	75,86	neuraminidase	12,25	oseltamivir	neuraminidase	MESH:D053139	4758	Chemical	Gene	laninamivir_octanoate|nmod|START_ENTITY laninamivir_octanoate|amod|END_ENTITY	Long-acting neuraminidase inhibitor laninamivir_octanoate -LRB- CS-8958 -RRB- versus oseltamivir as treatment for children with influenza_virus_infection .
20517627	0	oseltamivir	33,44	neuraminidase	59,72	oseltamivir	neuraminidase	MESH:D053139	4758	Chemical	Gene	resistance|compound|START_ENTITY simulation|nmod|resistance simulation|nmod|END_ENTITY	Molecular dynamics simulation of oseltamivir resistance in neuraminidase of avian influenza H5N1 virus .
20836794	1	oseltamivir	182,193	neuraminidase	149,162	oseltamivir	neuraminidase	MESH:D053139	4758	Chemical	Gene	inhibitors|nmod|START_ENTITY inhibitors|amod|END_ENTITY	BACKGROUND : First-line treatment of influenza_A 2009 H1N1 relies on neuraminidase inhibitors such as oseltamivir .
20936975	0	oseltamivir	65,76	neuraminidase	12,25	oseltamivir	neuraminidase	MESH:D053139	4758	Chemical	Gene	laninamivir_octanoate|nmod|START_ENTITY laninamivir_octanoate|amod|END_ENTITY	Long-acting neuraminidase inhibitor laninamivir_octanoate versus oseltamivir for treatment of influenza : A double-blind , randomized , noninferiority clinical trial .
21172786	0	oseltamivir	50,61	neuraminidase	73,86	oseltamivir	neuraminidase	MESH:D053139	4758	Chemical	Gene	mutation|compound|START_ENTITY mutation|compound|END_ENTITY	Pandemic H1N1 2009 influenza virus with the H275Y oseltamivir resistance neuraminidase mutation shows a small compromise in enzyme activity and viral fitness .
21489803	0	oseltamivir	40,51	neuraminidase	74,87	oseltamivir	neuraminidase	MESH:D053139	4758	Chemical	Gene	class|nmod|START_ENTITY selectivity|nmod|class analogs|nsubj|selectivity analogs|nmod|END_ENTITY	Inhibitor selectivity of a new class of oseltamivir analogs against viral neuraminidase over human neuraminidase enzymes .
21489803	0	oseltamivir	40,51	neuraminidase	99,112	oseltamivir	neuraminidase	MESH:D053139	4758	Chemical	Gene	class|nmod|START_ENTITY selectivity|nmod|class analogs|nsubj|selectivity analogs|nmod|neuraminidase neuraminidase|nmod|enzymes enzymes|compound|END_ENTITY	Inhibitor selectivity of a new class of oseltamivir analogs against viral neuraminidase over human neuraminidase enzymes .
21679678	0	oseltamivir	101,112	neuraminidase	154,167	oseltamivir	neuraminidase	MESH:D053139	4758	Chemical	Gene	START_ENTITY|amod|due due|nmod|mutation mutation|compound|END_ENTITY	Increased detection in Australia and Singapore of a novel influenza A -LRB- H1N1 -RRB- 2009 variant with reduced oseltamivir and zanamivir sensitivity due to a S247N neuraminidase mutation .
22000086	0	oseltamivir	183,194	neuraminidase	79,92	oseltamivir	neuraminidase	MESH:D053139	4758	Chemical	Gene	marker|compound|START_ENTITY detection|nmod|marker characterize|nmod|detection characterize|dobj|residue residue|amod|END_ENTITY	Reverse-transcription polymerase chain reaction/pyrosequencing to characterize neuraminidase H275 residue of influenza_A_2009_H1N1_virus for rapid and specific detection of the viral oseltamivir resistance marker in a clinical laboratory .
22544690	0	oseltamivir	23,34	neuraminidase	67,80	oseltamivir	neuraminidase	MESH:D053139	4758	Chemical	Gene	resistance|compound|START_ENTITY cause|nmod|resistance Exploring|dobj|cause END_ENTITY|csubj|Exploring	Exploring the cause of oseltamivir resistance against mutant H274Y neuraminidase by molecular simulation approach .
22563014	0	oseltamivir	132,143	neuraminidase	72,85	oseltamivir	neuraminidase	MESH:D053139	4758	Chemical	Gene	conferring|nmod|START_ENTITY conferring|nsubj|viruses viruses|nmod|mutations mutations|amod|END_ENTITY	In vitro passaging of a pandemic H1N1/09 virus selects for viruses with neuraminidase mutations conferring high-level resistance to oseltamivir and peramivir , but not to zanamivir .
22644080	0	oseltamivir	52,63	neuraminidase	26,39	oseltamivir	neuraminidase	MESH:D053139	4758	Chemical	Gene	effectiveness|dep|START_ENTITY effectiveness|nmod|inhibitors inhibitors|amod|END_ENTITY	Clinical effectiveness of neuraminidase inhibitors -- oseltamivir , zanamivir , laninamivir , and peramivir -- for treatment of influenza_A -LRB- H3N2 -RRB- _ and_A -LRB- H1N1 -RRB- pdm09_infection : an observational study in the 2010-2011 influenza season in Japan .
22936969	0	oseltamivir	89,100	neuraminidase	41,54	oseltamivir	neuraminidase	MESH:D053139	4758	Chemical	Gene	susceptibility|nmod|START_ENTITY confers|dobj|susceptibility confers|nsubj|mutation mutation|nmod|A A|amod|END_ENTITY	I223R mutation in influenza A -LRB- H1N1 -RRB- pdm09 neuraminidase confers reduced susceptibility to oseltamivir and zanamivir and enhanced resistance with H275Y .
23053629	0	oseltamivir	32,43	neuraminidase	96,109	oseltamivir	neuraminidase	MESH:D053139	4758	Chemical	Gene	resistance|compound|START_ENTITY mechanisms|dep|resistance mediated|nsubj|mechanisms mediated|nmod|END_ENTITY	Molecular mechanisms underlying oseltamivir resistance mediated by an I117V substitution in the neuraminidase of subtype H5N1 avian influenza_A_viruses .
23244438	0	oseltamivir	104,115	neuraminidase	36,49	oseltamivir	neuraminidase	MESH:D053139	4758	Chemical	Gene	analogue|compound|START_ENTITY applied|nmod|analogue approach|acl|applied approach|dep|Increasing Increasing|dobj|absorption absorption|nmod|inhibitors inhibitors|compound|END_ENTITY	Increasing oral absorption of polar neuraminidase inhibitors : a prodrug transporter approach applied to oseltamivir analogue .
23385316	0	oseltamivir	12,23	neuraminidase	81,94	oseltamivir	neuraminidase	MESH:D053139	4758	Chemical	Gene	substitutions|compound|START_ENTITY Analysis|nmod|substitutions END_ENTITY|nsubj|Analysis	Analysis of oseltamivir resistance substitutions in influenza virus glycoprotein neuraminidase using a lentivirus-based surrogate assay system .
23824808	0	oseltamivir	117,128	neuraminidase	54,67	oseltamivir	neuraminidase	MESH:D053139	4758	Chemical	Gene	resistance|compound|START_ENTITY mechanisms|nmod|resistance offers|nmod|mechanisms END_ENTITY|ccomp|offers	Functional and structural analysis of influenza virus neuraminidase N3 offers further insight into the mechanisms of oseltamivir resistance .
24366752	0	oseltamivir	145,156	neuraminidase	54,67	oseltamivir	neuraminidase	MESH:D053139	4758	Chemical	Gene	resistance|compound|START_ENTITY END_ENTITY|nmod|resistance	A conformational restriction in the influenza_A_virus neuraminidase binding site by R152 results in a combinational effect of I222T and H274Y on oseltamivir resistance .
24795482	0	oseltamivir	77,88	neuraminidase	30,43	oseltamivir	neuraminidase	MESH:D053139	4758	Chemical	Gene	resistance|acl|START_ENTITY confers|dobj|resistance confers|nsubj|substitution substitution|nmod|END_ENTITY	A novel I221L substitution in neuraminidase confers high-level resistance to oseltamivir in influenza B viruses .
25605596	0	oseltamivir	67,78	neuraminidase	44,57	oseltamivir	neuraminidase	MESH:D053139	4758	Chemical	Gene	resistance|compound|START_ENTITY avoid|dobj|resistance Targeting|advcl|avoid Targeting|dobj|cluster cluster|nmod|residues residues|nmod|END_ENTITY	Targeting a cluster of arginine residues of neuraminidase to avoid oseltamivir resistance in influenza A -LRB- H1N1 -RRB- : a theoretical study .
25859271	0	oseltamivir	26,37	neuraminidase	41,54	oseltamivir	neuraminidase	MESH:D053139	4758	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|amod|END_ENTITY	In silico modification of oseltamivir as neuraminidase inhibitor of influenza_A_virus_subtype_H1N1 .
26044768	0	oseltamivir	28,39	neuraminidase	142,155	oseltamivir	neuraminidase	MESH:D053139	4758	Chemical	Gene	efficiency|compound|START_ENTITY study|nmod|efficiency END_ENTITY|nsubj|study	A 3D-RISM/RISM study of the oseltamivir binding efficiency with the wild-type and resistance-associated mutant forms of the viral influenza B neuraminidase .
26247418	0	oseltamivir	151,162	neuraminidase	117,130	oseltamivir	neuraminidase	MESH:D053139	4758	Chemical	Gene	does|dobj|START_ENTITY does|nsubj|mutations mutations|compound|END_ENTITY	Difluorosialic_acids , potent novel influenza virus neuraminidase inhibitors , induce fewer drug resistance-associated neuraminidase mutations than does oseltamivir .
26247418	0	oseltamivir	151,162	neuraminidase	51,64	oseltamivir	neuraminidase	MESH:D053139	4758	Chemical	Gene	does|dobj|START_ENTITY induce|dep|does induce|nsubj|Difluorosialic_acids Difluorosialic_acids|appos|inhibitors inhibitors|compound|END_ENTITY	Difluorosialic_acids , potent novel influenza virus neuraminidase inhibitors , induce fewer drug resistance-associated neuraminidase mutations than does oseltamivir .
26257512	0	oseltamivir	38,49	neuraminidase	79,92	oseltamivir	neuraminidase	MESH:D053139	4758	Chemical	Gene	cross-resistance|nmod|START_ENTITY Understanding|dobj|cross-resistance influenza|csubj|Understanding influenza|dobj|mutations mutations|amod|END_ENTITY	Understanding the cross-resistance of oseltamivir to H1N1 and H5N1 influenza A neuraminidase mutations using multidimensional computational analyses .
26935590	0	oseltamivir	114,125	neuraminidase	40,53	oseltamivir	neuraminidase	MESH:D053139	4758	Chemical	Gene	resistance|nmod|START_ENTITY virus|nmod|resistance quasispecies|nmod|virus quasispecies|amod|END_ENTITY	The significance of naturally occurring neuraminidase quasispecies of H5N1_avian_influenza virus on resistance to oseltamivir : a point of concern .
19336914	0	osemozotan	22,32	c-Fos	94,99	osemozotan	c-Fos	MESH:C096294	14281(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|amod|END_ENTITY	Inhibitory effects of osemozotan , a serotonin 1A-receptor agonist , on methamphetamine-induced c-Fos expression in prefrontal cortical neurons .
27001618	0	osmotin	6,13	SREBP2	23,29	osmotin	SREBP2	null	6721	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Novel osmotin inhibits SREBP2 via the AdipoR1/AMPK/SIRT1 pathway to improve Alzheimer 's _ disease neuropathological deficits .
17979700	0	otamixaban	41,51	Factor_Xa	21,30	otamixaban	Factor Xa	MESH:C435830	2159	Chemical	Gene	START_ENTITY|nsubj|discovery discovery|nmod|inhibitor inhibitor|compound|END_ENTITY	The discovery of the Factor_Xa inhibitor otamixaban : from lead identification to clinical development .
16411387	0	otamixaban	60,70	factor_Xa	81,90	otamixaban	factor Xa	MESH:C435830	2159	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Pharmacodynamic markers in the early clinical assessment of otamixaban , a direct factor_Xa inhibitor .
17502577	0	otamixaban	48,58	factor_Xa	101,110	otamixaban	factor Xa	MESH:C435830	2159	Chemical	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Randomized , double-blind , dose-ranging study of otamixaban , a novel , parenteral , short-acting direct factor_Xa inhibitor , in percutaneous coronary intervention : the SEPIA-PCI trial .
2177192	0	ouabain	11,18	ATPase	22,28	ouabain	ATPase	MESH:D010042	1769	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activities activities|compound|END_ENTITY	Effects of ouabain on ATPase activities in human erythrocyte membranes .
227843	0	ouabain	11,18	ATPase	40,46	ouabain	ATPase	MESH:D010042	1769	Chemical	Gene	Binding|nmod|START_ENTITY Binding|dep|END_ENTITY	Binding of ouabain to Na + , K + - dependent ATPase during the ATPase reaction .
20403403	0	ouabain	81,88	Akt	14,17	ouabain	Akt	MESH:D010042	24185(Tax:10116)	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of Akt signaling in rat brain by intracerebroventricular injection of ouabain : a rat model for mania .
12556359	0	ouabain	10,17	CFTR	21,25	ouabain	CFTR	MESH:D010042	1080	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of ouabain on CFTR gene expression in human Calu-3 cells .
18632735	0	ouabain	24,31	ERK1/2	14,20	ouabain	ERK1/2	MESH:D010042	50689;116590	Chemical	Gene	utilization|compound|START_ENTITY Regulation|nmod|utilization Regulation|nmod|END_ENTITY	Regulation of ERK1/2 by ouabain and Na-K-ATPase-dependent energy utilization and AMPK activation in parotid acinar cells .
8543010	0	ouabain	22,29	NF-kappa_B	104,114	ouabain	NF-kappa B	MESH:D010042	18033(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|involvement involvement|nmod|END_ENTITY	Stimulatory effect of ouabain on VCAM-1 and iNOS expression in murine endothelial cells : involvement of NF-kappa_B .
8543010	0	ouabain	22,29	VCAM-1	33,39	ouabain	VCAM-1	MESH:D010042	22329(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Stimulatory effect of ouabain on VCAM-1 and iNOS expression in murine endothelial cells : involvement of NF-kappa_B .
9440253	0	ouabain	10,17	insulin	21,28	ouabain	insulin	MESH:D010042	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of ouabain on insulin secretion in the amphibian pancreas .
24772963	0	ouabain	110,117	m-calpain	10,19	ouabain	m-calpain	MESH:D010042	281662(Tax:9913)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|cells cells|amod|END_ENTITY	Effect of m-calpain in PKCalpha-mediated proliferation of pulmonary artery smooth muscle cells by low dose of ouabain .
6312252	0	ouabain	73,80	parathyroid_hormone	14,33	ouabain	parathyroid hormone	MESH:D010042	280903(Tax:9913)	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of parathyroid_hormone release from dispersed bovine cells by ouabain .
3017854	0	ouabain	22,29	renin	67,72	ouabain	renin	MESH:D010042	5972	Chemical	Gene	responses|nmod|START_ENTITY responses|nmod|hypertension hypertension|compound|END_ENTITY	Vascular responses to ouabain and norepinephrine in low and normal renin hypertension .
3550047	0	ouabain	59,66	renin	42,47	ouabain	renin	MESH:D010042	100358545(Tax:9986)	Chemical	Gene	effect|nmod|START_ENTITY control|dep|effect control|nmod|END_ENTITY	Secretion control for active and inactive renin : effect of ouabain on release from rabbit kidney cortex slices .
4375182	0	ouabain	10,17	renin	21,26	ouabain	renin	MESH:D010042	403838(Tax:9615)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of ouabain on renin secretion in anaesthetized dogs .
6991669	0	ouabain	33,40	renin	72,77	ouabain	renin	MESH:D010042	24715(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY potassium|nsubj|effects potassium|nmod|secretion secretion|compound|END_ENTITY	Separate and combined effects of ouabain and extracellular potassium on renin secretion from rat renal cortical slices .
7096201	0	oudenone	78,86	phenylalanine_hydroxylase	14,39	oudenone	phenylalanine hydroxylase	MESH:C002780	5053	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of phenylalanine_hydroxylase , a pterin-requiring monooxygenase , by oudenone and its derivatives .
16685364	0	overdose_fluoride	15,32	TGF-beta1	54,63	overdose fluoride	TGF-beta1	null	59086(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- The effect of overdose_fluoride on the expression of TGF-beta1 in rat 's dental pulps -RSB- .
16685365	0	overdose_fluoride	11,28	bone_sialoprotein	46,63	overdose fluoride	bone sialoprotein	null	24477(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of overdose_fluoride on expression of bone_sialoprotein in developing dental tissues of rats -RSB- .
16999342	0	overdose_fluoride	11,28	enamelin	50,58	overdose fluoride	enamelin	null	289525(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of overdose_fluoride on the expression of enamelin in rat mandibular incisor -RSB- .
22608962	0	oxadiazole	55,65	DGAT-1	66,72	oxadiazole	DGAT-1	CHEBI:46685	8694	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Identification , optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes .
20036129	0	oxadiazole	39,49	soluble_guanylyl_cyclase	79,103	oxadiazole	soluble guanylyl cyclase	CHEBI:46685	25206(Tax:10116)	Chemical	Gene	derivatives|amod|START_ENTITY evaluation|nmod|derivatives evaluation|nmod|inhibitors inhibitors|nmod|END_ENTITY	Synthesis and biological evaluation of oxadiazole derivatives as inhibitors of soluble_guanylyl_cyclase .
20493688	0	oxadiazole	37,47	tyrosinase	87,97	oxadiazole	tyrosinase	CHEBI:46685	7299	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Synthesis and biological activity of oxadiazole and triazolothiadiazole derivatives as tyrosinase inhibitors .
8580911	0	oxadiazolone	96,108	glutathione_S-transferase	49,74	oxadiazolone	glutathione S-transferase	null	48337(Tax:7227)	Chemical	Gene	studies|nmod|START_ENTITY studies|nmod|END_ENTITY	Developmental studies on Drosophila_melanogaster glutathione_S-transferase and its induction by oxadiazolone .
3814578	0	oxalacetate	19,30	pyruvate_carboxylase	34,54	oxalacetate	pyruvate carboxylase	null	5091	Chemical	Gene	Decarboxylation|nmod|START_ENTITY Decarboxylation|nmod|END_ENTITY	Decarboxylation of oxalacetate by pyruvate_carboxylase .
17664030	0	oxalamide	38,47	PAI-1	9,14	oxalamide	PAI-1	CHEBI:48248	5054	Chemical	Gene	derivatives|amod|START_ENTITY activity|nmod|derivatives activity|amod|END_ENTITY	In vitro PAI-1 inhibitory activity of oxalamide derivatives .
12624657	0	oxalate	70,77	Tamm-Horsfall_protein	11,32	oxalate	Tamm-Horsfall protein	null	403510(Tax:9615)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of Tamm-Horsfall_protein on the protection of MCDK cells from oxalate induced free radical_injury .
26538444	0	oxalate	32,39	dPrestin	56,64	oxalate	dPrestin	null	39996(Tax:7227)	Chemical	Gene	transport|amod|START_ENTITY transport|nmod|END_ENTITY	Sulfate and thiosulfate inhibit oxalate transport via a dPrestin -LRB- Slc26a6 -RRB- - dependent mechanism in an insect model of calcium_oxalate nephrolithiasis .
11142487	0	oxaliplatin	46,57	CPT-11	19,25	oxaliplatin	CPT-11	MESH:C030110	963084(Tax:115711)	Chemical	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	Dose escalation of CPT-11 in combination with oxaliplatin using an every two weeks schedule : a phase I study in advanced gastrointestinal_cancer patients .
18633248	0	oxaliplatin	105,116	GSTP1	77,82	oxaliplatin	GSTP1	MESH:C030110	2950	Chemical	Gene	Impact|nmod|START_ENTITY Impact|nmod|END_ENTITY	-LSB- Impact of single nucleotide polymorphisms in glutathione_S_transferase gene GSTP1 in the treatment with oxaliplatin based chemotherapy -RSB- .
25175346	0	oxaliplatin	34,45	HNF4a	0,5	oxaliplatin	HNF4a	MESH:C030110	3172	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	HNF4a induced chemosensitivity to oxaliplatin and 5-FU mediated by OCT1 and CNT3 in renal_cell_carcinoma .
19266094	0	oxaliplatin	106,117	MMP7	12,16	oxaliplatin	MMP7	MESH:C030110	4316	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of MMP7 and its cross-talk with the FAS/FASL system during the acquisition of chemoresistance to oxaliplatin .
23636450	0	oxaliplatin	87,98	PARP	132,136	oxaliplatin	PARP	MESH:C030110	142	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	MSH3 expression does not influence the sensitivity of colon_cancer HCT116 cell line to oxaliplatin and poly -LRB- ADP-ribose -RRB- _ polymerase -LRB- PARP -RRB- inhibitor as monotherapy or in combination .
24098947	0	oxaliplatin	58,69	RKIP	0,4	oxaliplatin	RKIP	MESH:C030110	5037	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|phosphorylation phosphorylation|compound|END_ENTITY	RKIP phosphorylation and STAT3 activation is inhibited by oxaliplatin and camptothecin and are associated with poor prognosis in stage II colon_cancer patients .
18832821	0	oxaliplatin	42,53	S-1	18,21	oxaliplatin	S-1	MESH:C030110	5707	Chemical	Gene	trial|nmod|START_ENTITY trial|nmod|END_ENTITY	Phase II trial of S-1 in combination with oxaliplatin in previously untreated patients with recurrent or inoperable biliary_tract_cancer .
21326246	0	oxaliplatin	36,47	S-1	18,21	oxaliplatin	S-1	MESH:C030110	5707	Chemical	Gene	combined|nmod|START_ENTITY END_ENTITY|acl|combined	Phase II study of S-1 combined with oxaliplatin as therapy for patients with metastatic biliary_tract_cancer : influence of the CYP2A6 polymorphism on pharmacokinetics and clinical activity .
21968463	0	oxaliplatin	78,89	S-1	39,42	oxaliplatin	S-1	MESH:C030110	5707	Chemical	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	Phase I study of two schedules of oral S-1 in combination with fixed doses of oxaliplatin and bevacizumab in patients with advanced solid tumors .
23494222	0	oxaliplatin	17,28	S-1	39,42	oxaliplatin	S-1	MESH:C030110	5707	Chemical	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	A pilot study of oxaliplatin with oral S-1 as second-line chemotherapy for patients with recurrent adenocarcimona of the uterine cervix .
24023346	0	oxaliplatin	21,32	S-1	43,46	oxaliplatin	S-1	MESH:C030110	5707	Chemical	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	Feasibility study of oxaliplatin with oral S-1 or capecitabine as first-line therapy for patients with metastases from colorectal_cancer .
24839048	0	oxaliplatin	56,67	S-1	32,35	oxaliplatin	S-1	MESH:C030110	5707	Chemical	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	A phase I trial of preoperative S-1 in combination with oxaliplatin and pelvic radiation for lower rectal_cancer with T4 and lateral pelvic lymph node metastasis .
19383922	10	oxaliplatin	1432,1443	Src	1454,1457	oxaliplatin	Src	MESH:C030110	6714	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Therefore , we conclude that oxaliplatin activates Src through a ROS-dependent mechanism .
25208577	0	oxaliplatin	29,40	Src	0,3	oxaliplatin	Src	MESH:C030110	6714	Chemical	Gene	modulated|nmod|START_ENTITY modulated|nsubjpass|activity activity|compound|END_ENTITY	Src activity is modulated by oxaliplatin and correlates with outcomes after hepatectomy for metastatic colorectal_cancer .
20233520	0	oxaliplatin	77,88	endostatin	44,54	oxaliplatin	endostatin	MESH:C030110	80781	Chemical	Gene	combined|nmod|START_ENTITY combined|nsubj|effect effect|nmod|END_ENTITY	The synergistic effect of recombinant human endostatin -LRB- YH-16 -RRB- combined with oxaliplatin on human colorectal_carcinoma .
26302162	0	oxaliplatin	34,45	leptin	60,66	oxaliplatin	leptin	MESH:C030110	16846(Tax:10090)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Ontogenic expression profiles and oxaliplatin regulation of leptin expression in mice dorsal root ganglion .
12553056	0	oxaliplatin	53,64	nerve_growth_factor	12,31	oxaliplatin	nerve growth factor	MESH:C030110	310738(Tax:10116)	Chemical	Gene	changes|nmod|START_ENTITY changes|compound|END_ENTITY	Circulating nerve_growth_factor level changes during oxaliplatin treatment-induced neurotoxicity in the rat .
16227409	0	oxaliplatin	35,46	p21waf1/cip1	8,20	oxaliplatin	p21waf1/cip1	MESH:C030110	1026	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nmod|effects	Role of p21waf1/cip1 in effects of oxaliplatin in colorectal_cancer cells .
19833818	0	oxaliplatin	173,184	p53	10,13	oxaliplatin	p53	MESH:C030110	7157	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|Impact Impact|nmod|expression expression|compound|END_ENTITY	Impact of p53 expression and microsatellite_instability on stage_III_colon_cancer disease-free survival in patients treated by 5-fluorouracil and leucovorin with or without oxaliplatin .
26998002	0	oxaliplatin	91,102	taxol_resistance_gene_1	11,34	oxaliplatin	taxol resistance gene 1	MESH:C030110	54458	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|amod|END_ENTITY	Effects of taxol_resistance_gene_1 expression on the chemosensitivity of SGC-7901 cells to oxaliplatin .
7669753	0	oxaloacetate	10,22	ATP-citrate_lyase	46,63	oxaloacetate	ATP-citrate lyase	MESH:D062907	47	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	Effect of oxaloacetate and phosphorylation on ATP-citrate_lyase activity .
25361010	0	oxamate	41,48	LDH-A	21,26	oxamate	LDH-A	CHEBI:18058	3939	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|effects effects|nmod|END_ENTITY	Different effects of LDH-A inhibition by oxamate in non-small_cell_lung_cancer cells .
19449386	0	oxamyl	23,29	acetylcholinesterase	70,90	oxamyl	acetylcholinesterase	MESH:C011960	105347545	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effects of exposure to oxamyl , carbofuran , dichlorvos , and lindane on acetylcholinesterase activity in the gills of the Pacific_oyster Crassostrea_gigas .
2751332	0	oxandrolone	63,74	Growth_hormone	0,14	oxandrolone	Growth hormone	MESH:D010074	2688	Chemical	Gene	secretion|nmod|START_ENTITY secretion|amod|END_ENTITY	Growth_hormone secretion in Turner 's _ syndrome and influence of oxandrolone and ethinyl_oestradiol .
11874177	0	oxandrolone	120,131	growth_hormone	91,105	oxandrolone	growth hormone	MESH:D010074	2688	Chemical	Gene	treated|nmod|START_ENTITY treated|nmod|END_ENTITY	Favorable final height outcome in girls with Ullrich-Turner_syndrome treated with low-dose growth_hormone together with oxandrolone despite starting treatment after 10 years of age .
2346341	0	oxandrolone	61,72	growth_hormone	87,101	oxandrolone	growth hormone	MESH:D010074	2688	Chemical	Gene	Treatment|nmod|START_ENTITY Treatment|nmod|END_ENTITY	Treatment of constitutional_delay_of_growth and puberty with oxandrolone compared with growth_hormone .
26322078	0	oxandrolone	10,21	growth_hormone	87,101	oxandrolone	growth hormone	MESH:D010074	2688	Chemical	Gene	therapy|amod|START_ENTITY Effect|nmod|therapy treated|nsubj|Effect treated|nmod|END_ENTITY	Effect of oxandrolone therapy on adult height in Turner_syndrome patients treated with growth_hormone : a meta-analysis .
3098462	0	oxandrolone	14,25	growth_hormone	33,47	oxandrolone	growth hormone	MESH:D010074	2688	Chemical	Gene	START_ENTITY|nmod|response response|amod|END_ENTITY	The effect of oxandrolone on the growth_hormone response to growth_hormone_releasing_hormone in children with constitutional growth delay .
8319371	0	oxandrolone	15,26	growth_hormone	34,48	oxandrolone	growth hormone	MESH:D010074	2688	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|axes axes|amod|END_ENTITY	The effects of oxandrolone on the growth_hormone and gonadal axes in boys with constitutional_delay_of_growth and puberty .
8563241	0	oxandrolone	20,31	growth_hormone	105,119	oxandrolone	growth hormone	MESH:D010074	2688	Chemical	Gene	promotion|nmod|START_ENTITY treated|nsubj|promotion treated|nmod|END_ENTITY	Growth promotion by oxandrolone in a girl with short_stature and early pubertal development treated with growth_hormone and gonadotropin-releasing_hormone-analogue .
9039510	0	oxandrolone	83,94	growth_hormone	17,31	oxandrolone	growth hormone	MESH:D010074	2688	Chemical	Gene	influence|nmod|START_ENTITY influence|nmod|monotherapy monotherapy|amod|END_ENTITY	The influence of growth_hormone monotherapy and growth_hormone in combination with oxandrolone or testosterone on thyroxid hormone parameters and thyroxine binding globulin in patients with Ullrich-Turner_syndrome .
9050948	0	oxandrolone	104,115	growth_hormone	65,79	oxandrolone	growth hormone	MESH:D010074	2688	Chemical	Gene	promotion|nmod|START_ENTITY promotion|nmod|therapy therapy|nmod|END_ENTITY	Growth promotion and Turner-specific bone age after therapy with growth_hormone and in combination with oxandrolone : when should therapy be started in Turner_syndrome ?
3098462	0	oxandrolone	14,25	growth_hormone_releasing_hormone	60,92	oxandrolone	growth hormone releasing hormone	MESH:D010074	2691	Chemical	Gene	effect|nmod|START_ENTITY effect|acl|END_ENTITY	The effect of oxandrolone on the growth_hormone response to growth_hormone_releasing_hormone in children with constitutional growth delay .
12475726	0	oxathiazine	10,21	estrone_sulfatase	36,53	oxathiazine	estrone sulfatase	null	412	Chemical	Gene	START_ENTITY|dobj|inhibitors inhibitors|nmod|END_ENTITY	Steroidal oxathiazine inhibitors of estrone_sulfatase .
7913315	0	oxatomide	23,32	IL2	53,56	oxatomide	IL2	MESH:C015408	3558	Chemical	Gene	START_ENTITY|nmod|induction induction|nmod|END_ENTITY	-LSB- Suppressive effect of oxatomide on the induction of IL2 responsiveness by DF-stimulated lymphocytes from patients with bronchial_asthma -RSB- .
26463039	0	oxatomide	61,70	P2X7_receptor	0,13	oxatomide	P2X7 receptor	MESH:C015408	5027	Chemical	Gene	START_ENTITY|nsubj|activity activity|amod|END_ENTITY	P2X7_receptor antagonist activity of the anti-allergic agent oxatomide .
20405259	0	oxazaphosphorines	15,32	multidrug_resistance-associated_protein_4	38,79	oxazaphosphorines	multidrug resistance-associated protein 4	null	10257	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of oxazaphosphorines with multidrug_resistance-associated_protein_4 -LRB- MRP4 -RRB- .
19916996	0	oxazepam	13,21	UGT2B15	45,52	oxazepam	UGT2B15	MESH:D010076	7366	Chemical	Gene	START_ENTITY|nmod|probe probe|nmod|END_ENTITY	Evidence for oxazepam as an in vivo probe of UGT2B15 : oxazepam clearance is reduced by UGT2B15 D85Y polymorphism but unaffected by UGT2B17 deletion .
20214645	0	oxazepam	80,88	adenosine_deaminase	38,57	oxazepam	adenosine deaminase	MESH:D010076	100	Chemical	Gene	studies|nmod|START_ENTITY studies|nmod|END_ENTITY	Kinetic and conformational studies of adenosine_deaminase upon interaction with oxazepam and lorazepam .
10915043	0	oxazole_benzenesulfonamides	12,39	beta3	56,61	oxazole benzenesulfonamides	beta3	null	1934	Chemical	Gene	START_ENTITY|nmod|agonists agonists|amod|END_ENTITY	Substituted oxazole_benzenesulfonamides as potent human beta3 adrenergic receptor agonists .
26231160	0	oxazolidinone	6,19	CGRP	53,57	oxazolidinone	CGRP	CHEBI:55374	796	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Novel oxazolidinone calcitonin_gene-related_peptide -LRB- CGRP -RRB- receptor antagonists for the acute treatment of migraine .
26231160	0	oxazolidinone	6,19	CGRP	53,57	oxazolidinone	CGRP	CHEBI:55374	796	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Novel oxazolidinone calcitonin_gene-related_peptide -LRB- CGRP -RRB- receptor antagonists for the acute treatment of migraine .
9364742	0	oxazolidinone	74,87	MAO-A	88,93	oxazolidinone	MAO-A	CHEBI:55374	29253(Tax:10116)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Absorption , distribution , metabolism and excretion of a new , 14C-labelled oxazolidinone MAO-A inhibitor in rat and dog .
10956183	0	oxazolidinone	26,39	alpha1A_adrenergic_receptor	75,102	oxazolidinone	alpha1A adrenergic receptor	CHEBI:55374	146	Chemical	Gene	START_ENTITY|nmod|antagonist antagonist|amod|END_ENTITY	De novo design of a novel oxazolidinone analogue as a potent and selective alpha1A_adrenergic_receptor antagonist with high oral bioavailability .
26231160	0	oxazolidinone	6,19	calcitonin_gene-related_peptide	20,51	oxazolidinone	calcitonin gene-related peptide	CHEBI:55374	796	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|amod|END_ENTITY	Novel oxazolidinone calcitonin_gene-related_peptide -LRB- CGRP -RRB- receptor antagonists for the acute treatment of migraine .
26231160	0	oxazolidinone	6,19	calcitonin_gene-related_peptide	20,51	oxazolidinone	calcitonin gene-related peptide	CHEBI:55374	796	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|amod|END_ENTITY	Novel oxazolidinone calcitonin_gene-related_peptide -LRB- CGRP -RRB- receptor antagonists for the acute treatment of migraine .
23701517	0	oxazolidinones	43,57	tankyrase	104,113	oxazolidinones	tankyrase	MESH:D023303	8658	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Discovery of novel , induced-pocket binding oxazolidinones as potent , selective , and orally bioavailable tankyrase inhibitors .
25515858	4	oxazolone	628,637	FcRy	576,580	oxazolone	FcRy	MESH:D010081	435653(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|responses responses|compound|END_ENTITY	In this study , we show that FcRy deficiency_decreases_ear-swelling responses to oxazolone in mice .
7712128	0	oxetanes	29,37	Renin	0,5	oxetanes	Renin	CHEBI:38784	5972	Chemical	Gene	inhibitors|dep|START_ENTITY inhibitors|compound|END_ENTITY	Renin inhibitors : C-terminal oxetanes as potent transition-state mimics .
3662051	0	oxidoreductase	44,58	diaphorase	60,70	oxidoreductase	diaphorase	null	1738	Chemical	Gene	Activity|nmod|START_ENTITY Activity|appos|END_ENTITY	Activity and localization of NADH-dependant oxidoreductase -LRB- diaphorase -RRB- in boar spermatozoa .
23022663	0	oxidosqualene	63,76	Erg7	86,90	oxidosqualene	Erg7	MESH:C520393	856470(Tax:4932)	Chemical	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Characterization of a mutation that results in independence of oxidosqualene cyclase -LRB- Erg7 -RRB- activity from the downstream 3-ketoreductase -LRB- Erg27 -RRB- in the yeast ergosterol biosynthetic pathway .
11706015	0	oxidosqualene	6,19	Erg7p	29,34	oxidosqualene	Erg7p	MESH:C520393	856470(Tax:4932)	Chemical	Gene	cyclase|compound|START_ENTITY cyclase|appos|END_ENTITY	Yeast oxidosqualene cyclase -LRB- Erg7p -RRB- is a major component of lipid particles .
12842197	0	oxidosqualene	83,96	Erg7p	106,111	oxidosqualene	Erg7p	MESH:C520393	856470(Tax:4932)	Chemical	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	In yeast sterol biosynthesis the 3-keto reductase protein -LRB- Erg27p -RRB- is required for oxidosqualene cyclase -LRB- Erg7p -RRB- activity .
19879375	0	oxidosqualene	16,29	Erg7p	39,44	oxidosqualene	Erg7p	MESH:C520393	856470(Tax:4932)	Chemical	Gene	cyclase|amod|START_ENTITY Interactions|nmod|cyclase Interactions|appos|END_ENTITY	Interactions of oxidosqualene cyclase -LRB- Erg7p -RRB- with 3-keto reductase -LRB- Erg27p -RRB- and other enzymes of sterol biosynthesis in yeast .
19862504	0	oxime	133,138	butyrylcholinesterase	80,101	oxime	butyrylcholinesterase	CHEBI:25750	100729351	Chemical	Gene	therapy|amod|START_ENTITY END_ENTITY|nmod|therapy	Biomarkers of organophosphorus nerve agent exposure : comparison of phosphylated butyrylcholinesterase and phosphylated albumin after oxime therapy .
8618930	0	oxime	34,39	cytochrome_P450	15,30	oxime	cytochrome P450	CHEBI:25750	4051	Chemical	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	Involvement of cytochrome_P450 in oxime production in glucosinolate biosynthesis as demonstrated by an in vitro microsomal enzyme system isolated from jasmonic_acid-induced seedlings of Sinapis alba L .
16904807	5	oximes	812,818	AChE	755,759	oximes	AChE	MESH:D010091	43	Chemical	Gene	action|nmod|START_ENTITY mechanism|nmod|action considered|xcomp|mechanism considered|nsubjpass|reactivation reactivation|nmod|END_ENTITY	Since reactivation of OP-inhibited AChE is considered to be the main mechanism of action of oximes , human erythrocyte AChE can be exploited to test the efficacy of new oximes .
16904807	5	oximes	888,894	AChE	755,759	oximes	AChE	MESH:D010091	43	Chemical	Gene	efficacy|nmod|START_ENTITY test|dobj|efficacy exploited|xcomp|test exploited|advcl|considered considered|nsubjpass|reactivation reactivation|nmod|END_ENTITY	Since reactivation of OP-inhibited AChE is considered to be the main mechanism of action of oximes , human erythrocyte AChE can be exploited to test the efficacy of new oximes .
18281016	0	oximes	11,17	AChE	69,73	oximes	AChE	MESH:D010091	43	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of oximes on rate of decarbamylation of human red blood cell AChE measured with two different methods .
21787634	0	oximes	43,49	AChE	29,33	oximes	AChE	MESH:D010091	43	Chemical	Gene	START_ENTITY|nsubj|Reactivation Reactivation|nmod|END_ENTITY	Reactivation of VX-inhibited AChE by novel oximes having two oxygen atoms in the linker .
22827894	0	oximes	138,144	AChE	106,110	oximes	AChE	MESH:D010091	43	Chemical	Gene	START_ENTITY|amod|kinetic kinetic|nmod|data data|nmod|END_ENTITY	Structural requirements for effective oximes -- evaluation of kinetic in vitro data with phosphylated human AChE and structurally different oximes .
22827894	0	oximes	38,44	AChE	106,110	oximes	AChE	MESH:D010091	43	Chemical	Gene	requirements|nmod|START_ENTITY requirements|dep|evaluation evaluation|nmod|oximes oximes|amod|kinetic kinetic|nmod|data data|nmod|END_ENTITY	Structural requirements for effective oximes -- evaluation of kinetic in vitro data with phosphylated human AChE and structurally different oximes .
22960624	0	oximes	17,23	AChE	66,70	oximes	AChE	MESH:D010091	43	Chemical	Gene	START_ENTITY|nmod|reactivation reactivation|nmod|END_ENTITY	Centrally acting oximes in reactivation of tabun-phosphoramidated AChE .
2260991	0	oximes	22,28	acetylcholinesterase	83,103	oximes	acetylcholinesterase	MESH:D010091	100009390(Tax:9986)	Chemical	Gene	Evaluation|nmod|START_ENTITY END_ENTITY|nsubj|Evaluation	Evaluation of several oximes as reactivators of unaged soman-inhibited whole blood acetylcholinesterase in rabbits .
26416217	0	oxindole	38,46	VEGFR-2	62,69	oxindole	VEGFR-2	MESH:C508198	3791	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	QSAR and molecular docking studies on oxindole derivatives as VEGFR-2 tyrosine kinase inhibitors .
17266627	0	oxindole	23,31	cyclin_dependent_kinase_1	47,72	oxindole	cyclin dependent kinase 1	MESH:C508198	983	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	3D-QSAR CoMFA study on oxindole derivatives as cyclin_dependent_kinase_1 -LRB- CDK1 -RRB- and cyclin_dependent_kinase_2 -LRB- CDK2 -RRB- inhibitors .
1507519	0	oxiracetam	15,25	CT-848	27,33	oxiracetam	CT-848	MESH:C040619	884679(Tax:272561)	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	The effects of oxiracetam -LRB- CT-848 -RRB- on local cerebral glucose utilization after focal cerebral_ischemia in rats .
24239908	0	oxo-centered_trinuclear_chromium_carboxylate	13,57	Cr3	86,89	oxo-centered trinuclear chromium carboxylate	Cr3	null	6998	Chemical	Gene	complexes|amod|START_ENTITY complexes|nmod|END_ENTITY	Formation of oxo-centered_trinuclear_chromium_carboxylate complexes and hydrolysis of Cr3 as established by paramagnetic -LRB- 2 -RRB- H NMR spectroscopy .
1858346	0	oxoglutarate	54,66	lipoamide_dehydrogenase	23,46	oxoglutarate	lipoamide dehydrogenase	null	1738	Chemical	Gene	complex|amod|START_ENTITY END_ENTITY|nmod|complex	-LSB- Kinetic properties of lipoamide_dehydrogenase of the oxoglutarate dehydrogenase complex of the human heart -RSB- .
263154	0	oxonic_acid	26,37	Urate-oxidase	0,13	oxonic acid	Urate-oxidase	MESH:D010094	22262(Tax:10090)	Chemical	Gene	liver|nmod|START_ENTITY END_ENTITY|nmod|liver	Urate-oxidase in liver of oxonic_acid treated mice .
23321418	0	oxophytodienoate	6,22	TaOPR1	38,44	oxophytodienoate	TaOPR1	null	101290675	Chemical	Gene	START_ENTITY|ccomp|confers confers|nsubj|END_ENTITY	Wheat oxophytodienoate reductase gene TaOPR1 confers salinity tolerance via enhancement of abscisic_acid signaling and reactive oxygen species scavenging .
3450532	0	oxotremorine	14,26	parathyroid_hormone	52,71	oxotremorine	parathyroid hormone	MESH:D010095	5741	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of oxotremorine on in-vitro secretion of parathyroid_hormone .
6807681	0	oxprenolol	14,24	renin	45,50	oxprenolol	renin	MESH:D010096	5972	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of oxprenolol and indomethacin on renin and aldosterone of normal subjects during low sodium diet .
3185874	5	oxyHb	741,746	EDRF	787,791	oxyHb	EDRF	null	51327	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The blocking effect of oxyHb to endothelium-derived_relaxing_factor -LRB- EDRF -RRB- did not appear for at least 3 hours after the extraluminal application of 10 -LRB- -5 -RRB- M oxyHb .
18561989	0	oxybutynin	20,30	c-Fos	49,54	oxybutynin	c-Fos	MESH:C005419	314322(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY administration|nmod|expression expression|amod|END_ENTITY	Effect of long-term oxybutynin administration on c-Fos expression in spinal neurons : inhibition of antimuscarinics on bladder afferents in conscious rats .
15039299	0	oxycodone	49,58	CYP2D6	29,35	oxycodone	CYP2D6	MESH:D010098	1565	Chemical	Gene	contribution|acl|START_ENTITY contribution|nmod|END_ENTITY	Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes .
22357901	0	oxycodone	76,85	TACE	109,113	oxycodone	TACE	MESH:D010098	6868	Chemical	Gene	START_ENTITY|nmod|control control|nmod|END_ENTITY	Liver_cancer : effects , safety , and cost-effectiveness of controlled-release oxycodone for pain control after TACE .
7107571	0	oxyferro	4,12	cytochrome_P-450scc	32,51	oxyferro	cytochrome P-450scc	null	1583	Chemical	Gene	complex|amod|START_ENTITY complex|nmod|END_ENTITY	The oxyferro complex of adrenal cytochrome_P-450scc .
20038050	0	oxyfluoride	90,101	Tm3	79,82	oxyfluoride	Tm3	MESH:C014559	7170	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Spectroscopic study on the interaction of glass matrixes and nanoparticles in Tm3 + doped oxyfluoride glass ceramics -RSB- .
17675410	0	oxygen	76,82	12/15-lipoxygenase	45,63	oxygen	12/15-lipoxygenase	MESH:D010100	246	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|nmod|channels	Molecular dioxygen enters the active site of 12/15-lipoxygenase via dynamic oxygen access channels .
9870556	0	oxygen	11,17	3-hydroxyanthranilate_oxidase	21,50	oxygen	3-hydroxyanthranilate oxidase	MESH:D010100	23498	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of oxygen on 3-hydroxyanthranilate_oxidase of the kynurenine pathway .
27033790	3	oxygen	403,409	4-HNE	446,451	oxygen	Bcl-2	MESH:D010100	12043(Tax:10090)	Chemical	Gene	species|compound|START_ENTITY species|appos|END_ENTITY	The relative content of reactive oxygen species -LRB- ROS -RRB- and 4-hydroxynonenal -LRB- 4-HNE -RRB- were detected by chemical fluorometric enzyme immunoassay .
20709391	0	oxygen	76,82	ABCA1	47,52	oxygen	ABCA1	MESH:D010100	19	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	The liver X receptor -LRB- LXR -RRB- and its target gene ABCA1 are regulated upon low oxygen in human trophoblast cells : a reason for alterations in preeclampsia ?
11121799	0	oxygen	64,70	ACE	86,89	oxygen	ACE	MESH:D010100	11421(Tax:10090)	Chemical	Gene	consumption|compound|START_ENTITY consumption|nmod|END_ENTITY	Potential role of eNOS in the therapeutic control of myocardial oxygen consumption by ACE inhibitors and amlodipine .
16380484	0	oxygen	96,102	AMP-activated_protein_kinase	14,42	oxygen	AMP-activated protein kinase	MESH:D010100	5562	Chemical	Gene	species|compound|START_ENTITY reduces|iobj|species reduces|nsubj|Activation Activation|nmod|END_ENTITY	Activation of AMP-activated_protein_kinase reduces hyperglycemia-induced mitochondrial reactive oxygen species production and promotes mitochondrial biogenesis in human umbilical vein endothelial cells .
21440488	0	oxygen	79,85	AMP-activated_protein_kinase	33,61	oxygen	AMP-activated protein kinase	MESH:D010100	5563	Chemical	Gene	species|compound|START_ENTITY END_ENTITY|nmod|species	Arecoline-mediated inhibition of AMP-activated_protein_kinase through reactive oxygen species is required for apoptosis induction .
23057846	0	oxygen	23,29	AMP-activated_protein_kinase	46,74	oxygen	AMP-activated protein kinase	MESH:D010100	5563	Chemical	Gene	species|compound|START_ENTITY enhance|nsubj|species enhance|dobj|activation activation|amod|END_ENTITY	Mitochondrial reactive oxygen species enhance AMP-activated_protein_kinase activation in the endothelium of patients with coronary_artery_disease and diabetes .
23108012	0	oxygen	142,148	AMP-activated_protein_kinase	14,42	oxygen	AMP-activated protein kinase	MESH:D010100	5563	Chemical	Gene	species|compound|START_ENTITY inhibition|nmod|species inhibits|nmod|inhibition inhibits|nsubj|Activation Activation|nmod|END_ENTITY	Activation of AMP-activated_protein_kinase inhibits albumin-induced endoplasmic reticulum stress and apoptosis through inhibition of reactive oxygen species .
25450395	0	oxygen	80,86	AMP-activated_protein_kinase	20,48	oxygen	AMP-activated protein kinase	MESH:D010100	5562	Chemical	Gene	deprivation-re-oxygenation|compound|START_ENTITY protect|nmod|deprivation-re-oxygenation END_ENTITY|xcomp|protect	Silibinin activates AMP-activated_protein_kinase to protect neuronal cells from oxygen and glucose deprivation-re-oxygenation .
17331470	0	oxygen	89,95	ASK1	0,4	oxygen	ASK1	MESH:D010100	4217	Chemical	Gene	species|compound|START_ENTITY accumulation|nmod|species activated|nmod|accumulation activated|nsubjpass|END_ENTITY	ASK1 is activated by arsenic_trioxide in leukemic cells through accumulation of reactive oxygen species and may play a negative role in induction of apoptosis .
17724081	0	oxygen	55,61	ASK1	173,177	oxygen	ASK1	MESH:D010100	4217	Chemical	Gene	activation|compound|START_ENTITY regulate|dobj|activation regulate|nmod|modulation modulation|nmod|interaction interaction|nmod|END_ENTITY	Thioredoxin and TRAF family proteins regulate reactive oxygen species-dependent activation of ASK1 through reciprocal modulation of the N-terminal homophilic interaction of ASK1 .
17724081	0	oxygen	55,61	ASK1	94,98	oxygen	ASK1	MESH:D010100	4217	Chemical	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Thioredoxin and TRAF family proteins regulate reactive oxygen species-dependent activation of ASK1 through reciprocal modulation of the N-terminal homophilic interaction of ASK1 .
1325381	0	oxygen	59,65	ATPase	11,17	oxygen	ATPase	MESH:D010100	1769	Chemical	Gene	radicals|compound|START_ENTITY induced|nmod|radicals inactivation|acl|induced END_ENTITY|dep|inactivation	-LRB- Na + + K + -RRB- - ATPase : inactivation and degradation induced by oxygen radicals .
137712	0	oxygen	33,39	ATPase	87,93	oxygen	ATPase	MESH:D010100	1769	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of increased pressures of oxygen , nitrogen , and helium on activity of a Na-K-Mg ATPase of beef brain .
1831462	0	oxygen	121,127	ATPase	50,56	oxygen	ATPase	MESH:D010100	1769	Chemical	Gene	exchange|compound|START_ENTITY using|dobj|exchange using|nsubj|Kinetics Kinetics|nmod|release release|amod|binding binding|nmod|cycle cycle|amod|END_ENTITY	Kinetics of ATP release and Pi binding during the ATPase cycle of lethocerus flight muscle fibres , using phosphate-water oxygen exchange .
19925794	0	oxygen	8,14	ATPase	24,30	oxygen	ATPase	MESH:D010100	1769	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	Singlet oxygen inhibits ATPase and proton translocation activity of the thylakoid ATP synthase CF1CFo .
2954954	0	oxygen	128,134	ATPase	15,21	oxygen	ATPase	MESH:D010100	1769	Chemical	Gene	exchange|compound|START_ENTITY probed|nmod|exchange probed|nsubj|Changes Changes|nmod|activity activity|amod|END_ENTITY	Changes in the ATPase activity of insect fibrillar flight muscle during calcium and strain activation probed by phosphate-water oxygen exchange .
2965703	0	oxygen	128,134	ATPase	15,21	oxygen	ATPase	MESH:D010100	1769	Chemical	Gene	exchange|compound|START_ENTITY probed|nmod|exchange probed|nsubj|Changes Changes|nmod|activity activity|amod|END_ENTITY	Changes in the ATPase activity of insect fibrillar flight muscle during sinusoidal length_oscillation probed by phosphate-water oxygen exchange .
6216920	0	oxygen	60,66	ATPase	21,27	oxygen	ATPase	MESH:D010100	1769	Chemical	Gene	exchange|compound|START_ENTITY nitrogenase|nmod|exchange site|nmod|nitrogenase site|amod|END_ENTITY	-LSB- Localization of the ATPase site of nitrogenase by isotopic oxygen exchange -LSB- 180 -RSB- - Pi in equilibrium with H20 -RSB- .
14971644	0	oxygen	68,74	Akt	51,54	oxygen	Akt	MESH:D010100	207	Chemical	Gene	species|compound|START_ENTITY species|compound|END_ENTITY	Arsenite induces HIF-1alpha and VEGF through PI3K , Akt and reactive oxygen species in DU145 human prostate_carcinoma cells .
18379870	0	oxygen	21,27	Akt	54,57	oxygen	Akt	MESH:D010100	24185(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY species|nmod|END_ENTITY	Increase in reactive oxygen species and activation of Akt signaling pathway in neuropathic_pain .
19690198	0	oxygen	39,45	Akt	79,82	oxygen	Akt	MESH:D010100	207	Chemical	Gene	inactivation|compound|START_ENTITY inactivation|nmod|END_ENTITY	15d-PGJ2 induces apoptosis by reactive oxygen species-mediated inactivation of Akt in leukemia and colorectal_cancer cells and shows in vivo antitumor activity .
11466560	0	oxygen	87,93	Angiotensin_II	0,14	oxygen	Angiotensin II	MESH:D010100	24179(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY role|nmod|species expression|dep|role induces|dobj|expression induces|nsubj|END_ENTITY	Angiotensin_II induces p27 -LRB- Kip1 -RRB- expression in renal tubules in vivo : role of reactive oxygen species .
12573135	0	oxygen	66,72	Angiotensin_II	0,14	oxygen	Angiotensin II	MESH:D010100	183	Chemical	Gene	species|compound|START_ENTITY increase|nmod|species induces|dobj|increase induces|nsubj|END_ENTITY	Angiotensin_II induces a rapid and transient increase of reactive oxygen species .
15770925	0	oxygen	109,115	Angiotensin_II	0,14	oxygen	Angiotensin II	MESH:D010100	183	Chemical	Gene	species|compound|START_ENTITY mediates|nmod|species mediates|nsubj|END_ENTITY	Angiotensin_II mediates high glucose-induced TGF-beta1 and fibronectin upregulation in HPMC through reactive oxygen species .
16249273	0	oxygen	84,90	Angiotensin_II	0,14	oxygen	Angiotensin II	MESH:D010100	183	Chemical	Gene	species|compound|START_ENTITY production|nmod|species requires|dobj|production requires|nsubj|stimulation stimulation|compound|END_ENTITY	Angiotensin_II stimulation of VEGF mRNA translation requires production of reactive oxygen species .
17463319	0	oxygen	100,106	Angiotensin_II	0,14	oxygen	Angiotensin II	MESH:D010100	24179(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY increases|nmod|species increases|nsubj|END_ENTITY	Angiotensin_II increases expression of alpha1C subunit of L-type calcium channel through a reactive oxygen species and cAMP response element-binding protein-dependent pathway in HL-1 myocytes .
21270817	0	oxygen	67,73	Angiotensin_II	0,14	oxygen	Angiotensin II	MESH:D010100	183	Chemical	Gene	production|compound|START_ENTITY induces|nmod|production induces|nsubj|END_ENTITY	Angiotensin_II induces human astrocyte senescence through reactive oxygen species production .
22215616	0	oxygen	103,109	Angiotensin_II	0,14	oxygen	Angiotensin II	MESH:D010100	183	Chemical	Gene	activation|compound|START_ENTITY induces|nmod|activation induces|nsubj|END_ENTITY	Angiotensin_II induces epithelial-to-mesenchymal transition in renal epithelial cells through reactive oxygen species/Src/caveolin-mediated activation of an epidermal growth factor receptor-extracellular_signal-regulated_kinase signaling pathway .
24037962	0	oxygen	93,99	Angiotensin_II	0,14	oxygen	Angiotensin II	MESH:D010100	24179(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY generation|nmod|species requires|dobj|generation requires|nsubj|activation activation|compound|END_ENTITY	Angiotensin_II activation of TRPC6 channels in rat podocytes requires generation of reactive oxygen species .
24729228	0	oxygen	43,49	Angiotensin_II	0,14	oxygen	Angiotensin II	MESH:D010100	11606(Tax:10090)	Chemical	Gene	consumption|compound|START_ENTITY reduces|dobj|consumption reduces|nsubj|END_ENTITY	Angiotensin_II reduces transport-dependent oxygen consumption but increases transport-independent oxygen consumption in immortalized mouse proximal tubular cells .
8244086	0	oxygen	44,50	Angiotensin_converting_enzyme	0,29	oxygen	Angiotensin converting enzyme	MESH:D010100	1636	Chemical	Gene	inhibitors|nmod|START_ENTITY inhibitors|amod|END_ENTITY	Angiotensin_converting_enzyme inhibitors as oxygen free radical scavengers .
17702967	0	oxygen	82,88	Apolipoprotein_E	0,16	oxygen	Apolipoprotein E	MESH:D010100	348	Chemical	Gene	treatment|compound|START_ENTITY END_ENTITY|nmod|treatment	Apolipoprotein_E genotype and response of carbon_monoxide poisoning to hyperbaric oxygen treatment .
15669087	0	oxygen	10,16	ArcA	41,45	oxygen	ArcA	MESH:D010100	9845996	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of oxygen on the Escherichia_coli ArcA and FNR regulation systems and metabolic responses .
15988767	0	oxygen	65,71	ArcA	10,14	oxygen	ArcA	MESH:D010100	9845996	Chemical	Gene	regulation|compound|START_ENTITY related|nmod|regulation related|nsubj|Effect Effect|nmod|END_ENTITY	Effect of ArcA and FNR on the expression of genes related to the oxygen regulation and the glycolysis pathway in Escherichia_coli under microaerobic growth conditions .
8626294	0	oxygen	61,67	ArcA	69,73	oxygen	ArcA	MESH:D010100	9845996	Chemical	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	The complex bet promoters of Escherichia_coli : regulation by oxygen -LRB- ArcA -RRB- , choline -LRB- BetI -RRB- , and osmotic stress .
17182545	0	oxygen	23,29	Atm	41,44	oxygen	Atm	MESH:D010100	11920(Tax:10090)	Chemical	Gene	species|compound|START_ENTITY species|nmod|END_ENTITY	Regulation of reactive oxygen species by Atm is essential for proper response to DNA double-strand breaks in lymphocytes .
19226375	0	oxygen	104,110	B-type_natriuretic_peptide	0,26	oxygen	B-type natriuretic peptide	MESH:D010100	4879	Chemical	Gene	consumption|compound|START_ENTITY END_ENTITY|nmod|consumption	B-type_natriuretic_peptide and C-terminal-pro-endothelin-1 for the prediction of severely impaired peak oxygen consumption .
16001273	0	oxygen	158,164	BCL-2	52,57	oxygen	BCL-2	MESH:D010100	24224(Tax:10116)	Chemical	Gene	therapy|compound|START_ENTITY treated|nmod|therapy Evaluation|acl|treated Evaluation|nmod|proteins proteins|nmod|family family|compound|END_ENTITY	Evaluation of the apoptosis-related proteins of the BCL-2 family in the traumatic penumbra area of the rat model of cerebral_contusion , treated by hyperbaric oxygen therapy : a quantitative immunohistochemical study .
19687201	0	oxygen	34,40	BLI-3	9,14	oxygen	BLI-3	MESH:D010100	171608(Tax:6239)	Chemical	Gene	species|compound|START_ENTITY generates|dobj|species generates|nsubj|END_ENTITY	Ce-Duox1 / BLI-3 generates reactive oxygen species as a protective innate immune mechanism in Caenorhabditis_elegans .
10867640	0	oxygen	59,65	Bax	45,48	oxygen	Bax	MESH:D010100	12028(Tax:10090)	Chemical	Gene	species|compound|START_ENTITY END_ENTITY|appos|species	Copper induces apoptosis in BA/F3beta cells : Bax , reactive oxygen species , and NFkappaB are involved .
14625274	0	oxygen	9,15	Bax	59,62	oxygen	Bax	MESH:D010100	24887(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY required|nsubjpass|species required|nmod|activation activation|compound|END_ENTITY	Reactive oxygen species are required for hyperoxia-induced Bax activation and cell death in alveolar epithelial cells .
17097638	0	oxygen	35,41	Bax	0,3	oxygen	Bax	MESH:D010100	12028(Tax:10090)	Chemical	Gene	production|nmod|START_ENTITY affects|dobj|production affects|nsubj|END_ENTITY	Bax affects production of reactive oxygen by the mitochondria of non-apoptotic neurons .
17172466	0	oxygen	9,15	Bax	74,77	oxygen	Bax	MESH:D010100	581	Chemical	Gene	species|compound|START_ENTITY activate|nsubj|species activate|dobj|END_ENTITY	Reactive oxygen species and p38_mitogen-activated_protein_kinase activate Bax to induce mitochondrial cytochrome_c release and apoptosis in response to malonate .
17549348	0	oxygen	9,15	Bax	33,36	oxygen	Bax	MESH:D010100	581	Chemical	Gene	species|compound|START_ENTITY regulate|nsubj|species regulate|dobj|translocation translocation|compound|END_ENTITY	Reactive oxygen species regulate Bax translocation and mitochondrial transmembrane potential , a possible mechanism for enhanced TRAIL-induced apoptosis by CCCP .
19574249	0	oxygen	9,15	Bax	48,51	oxygen	Bax	MESH:D010100	581	Chemical	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Reactive oxygen species-dependent activation of Bax and poly -LRB- ADP-ribose -RRB- _ polymerase-1 is required for mitochondrial_cell_death induced by triterpenoid_pristimerin in human cervical_cancer cells .
22056078	0	oxygen	9,15	Bax	46,49	oxygen	Bax	MESH:D010100	581	Chemical	Gene	species|compound|START_ENTITY MAPK|nsubj|species MAPK|xcomp|regulate regulate|dobj|translocation translocation|compound|END_ENTITY	Reactive oxygen species and p38 MAPK regulate Bax translocation and calcium redistribution in salubrinal-induced apoptosis of EBV-transformed B cells .
10514462	0	oxygen	24,30	Bcl-2	0,5	oxygen	Bcl-2	MESH:D010100	596	Chemical	Gene	radicals|compound|START_ENTITY END_ENTITY|dobj|radicals	Bcl-2 and mitochondrial oxygen radicals .
10657030	0	oxygen	137,143	Bcl-2	0,5	oxygen	Bcl-2	MESH:D010100	596	Chemical	Gene	species|compound|START_ENTITY production|nmod|species suppressing|dobj|production attenuates|advcl|suppressing attenuates|nsubj|overexpression overexpression|amod|END_ENTITY	Bcl-2 overexpression attenuates dopamine-induced apoptosis in an immortalized neural cell line by suppressing the production of reactive oxygen species .
11230808	0	oxygen	38,44	Bcl-2	218,223	oxygen	Bcl-2	MESH:D010100	596	Chemical	Gene	species|compound|START_ENTITY generation|nmod|species Changes|nmod|generation induced|nsubj|Changes induced|nmod|END_ENTITY	Changes in the generation of reactive oxygen species and in mitochondrial membrane potential during apoptosis induced by the antidepressants imipramine , clomipramine , and citalopram and the effects on these changes by Bcl-2 and Bcl-X -LRB- L -RRB- .
11236678	0	oxygen	22,28	Bcl-2	59,64	oxygen	Bcl-2	MESH:D010100	596	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|proteins proteins|amod|END_ENTITY	-LSB- Effect of hyperbaric oxygen on the expression of proteins Bcl-2 and Bax in the gerbil hippocampus CA1 following forebrain ischemia reperfusion -RSB- .
11355954	0	oxygen	128,134	Bcl-2	0,5	oxygen	Bcl-2	MESH:D010100	596	Chemical	Gene	species|compound|START_ENTITY generation|nmod|species involves|dobj|generation involves|nsubj|toxicity toxicity|amod|resistant resistant|advmod|END_ENTITY	Bcl-2 resistant mitochondrial toxicity mediated by the isoquinoline_carboxamide PK11195 involves de novo generation of reactive oxygen species .
11739725	0	oxygen	70,76	Bcl-2	0,5	oxygen	Bcl-2	MESH:D010100	12043(Tax:10090)	Chemical	Gene	death|nummod|START_ENTITY regulate|dobj|death chain|xcomp|regulate chain|nsubj|transport transport|compound|members members|amod|END_ENTITY	Bcl-2 family members and functional electron transport chain regulate oxygen deprivation-induced cell death .
14624451	0	oxygen	98,104	Bcl-2	0,5	oxygen	Bcl-2	MESH:D010100	24224(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY generation|nmod|species prevents|nmod|generation prevents|nsubj|END_ENTITY	Bcl-2 prevents hypoxia/reoxygenation-induced cell death through suppressed generation of reactive oxygen species and upregulation of Bcl-2 proteins .
14657380	0	oxygen	40,46	Bcl-2	11,16	oxygen	Bcl-2	MESH:D010100	596	Chemical	Gene	species|compound|START_ENTITY Control|nmod|species Control|nmod|expression expression|compound|END_ENTITY	Control of Bcl-2 expression by reactive oxygen species .
15298726	0	oxygen	9,15	Bcl-2	56,61	oxygen	Bcl-2	MESH:D010100	596	Chemical	Gene	species|compound|START_ENTITY control|nsubj|species control|dobj|expression expression|nmod|proteins proteins|compound|END_ENTITY	Reactive oxygen species -LRB- ROS -RRB- control the expression of Bcl-2 family proteins by regulating their phosphorylation and ubiquitination .
15528043	0	oxygen	54,60	Bcl-2	0,5	oxygen	Bcl-2	MESH:D010100	596	Chemical	Gene	production|compound|START_ENTITY regulate|dobj|production regulate|nsubj|proteins proteins|amod|END_ENTITY	Bcl-2 family proteins regulate mitochondrial reactive oxygen production and protect against oxidative stress .
15719027	0	oxygen	146,152	Bcl-2	38,43	oxygen	Bcl-2	MESH:D010100	12043(Tax:10090)	Chemical	Gene	species|compound|START_ENTITY scavenging|nmod|species suppression|dep|scavenging suppression|nmod|loss loss|compound|END_ENTITY	Ruthenium_red-mediated suppression of Bcl-2 loss and Ca -LRB- 2 + -RRB- release initiated by photodamage to the endoplasmic reticulum : scavenging of reactive oxygen species .
16990509	0	oxygen	9,15	Bcl-2	134,139	oxygen	Bcl-2	MESH:D010100	596	Chemical	Gene	species|compound|START_ENTITY mediate|nsubj|species mediate|dobj|activation activation|acl|induced induced|nmod|down-regulation down-regulation|compound|END_ENTITY	Reactive oxygen species mediate caspase activation and apoptosis induced by lipoic_acid in human lung epithelial cancer cells through Bcl-2 down-regulation .
17131910	0	oxygen	128,134	Bcl-2	95,100	oxygen	Bcl-2	MESH:D010100	24224(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY downregulation|nmod|species downregulation|nmod|END_ENTITY	Heat_stress induced apoptosis in BC-8 cells derived from AK-5 tumor involves downregulation of Bcl-2 and generation of reactive oxygen species .
17140381	0	oxygen	122,128	Bcl-2	79,84	oxygen	Bcl-2	MESH:D010100	596	Chemical	Gene	species|compound|START_ENTITY Changes|nmod|species Changes|nmod|expression expression|nmod|genes genes|acl|encoding encoding|dobj|enzymes enzymes|amod|END_ENTITY	Changes in expression of genes encoding antioxidant enzymes , heme_oxygenase-1 , Bcl-2 , and Bcl-xl and in level of reactive oxygen species in tumor cells resistant to doxorubicin .
17874842	0	oxygen	200,206	Bcl-2	152,157	oxygen	Bcl-2	MESH:D010100	596	Chemical	Gene	species|compound|START_ENTITY generate|dobj|species decomposes|xcomp|generate decomposes|nsubj|chromene-3-carboxylate chromene-3-carboxylate|appos|antagonist antagonist|nmod|proteins proteins|compound|END_ENTITY	Ethyl-2-amino-6-bromo-4 - -LRB- 1-cyano-2-ethoxy-2-oxoethyl -RRB- -4 H - _ chromene-3-carboxylate -LRB- HA_14-1 -RRB- , a prototype small-molecule antagonist against antiapoptotic Bcl-2 proteins , decomposes to generate reactive oxygen species that induce apoptosis .
19250964	0	oxygen	74,80	Bcl-2	117,122	oxygen	Bcl-2	MESH:D010100	12043(Tax:10090)	Chemical	Gene	species-dependent|compound|START_ENTITY species-dependent|acl|involving involving|dobj|END_ENTITY	Globular_adiponectin-induced RAW 264 apoptosis is regulated by a reactive oxygen species-dependent pathway involving Bcl-2 .
19855099	0	oxygen	56,62	Bcl-2	27,32	oxygen	Bcl-2	MESH:D010100	100774873	Chemical	Gene	regulation|compound|START_ENTITY regulate|nmod|regulation regulate|dobj|expression expression|compound|END_ENTITY	Sigma-1 receptors regulate Bcl-2 expression by reactive oxygen species-dependent transcriptional regulation of nuclear factor kappaB .
19855432	0	oxygen	81,87	Bcl-2	62,67	oxygen	Bcl-2	MESH:D010100	596	Chemical	Gene	species|compound|START_ENTITY species|amod|END_ENTITY	Prevention of premature senescence requires JNK regulation of Bcl-2 and reactive oxygen species .
20127174	0	oxygen	77,83	Bcl-2	101,106	oxygen	Bcl-2	MESH:D010100	596	Chemical	Gene	downregulation|compound|START_ENTITY downregulation|compound|END_ENTITY	Curcumin sensitizes non-small_cell_lung_cancer cell anoikis through reactive oxygen species-mediated Bcl-2 downregulation .
22491967	0	oxygen	117,123	Bcl-2	24,29	oxygen	Bcl-2	MESH:D010100	12043(Tax:10090)	Chemical	Gene	death|compound|START_ENTITY effects|nmod|death effects|nmod|END_ENTITY	Differential effects of Bcl-2 and caspases on mitochondrial permeabilization during endogenous or exogenous reactive oxygen species-induced cell death : a comparative study of H ___ O , paraquat , t-BHP , etoposide and TNF-a-induced cell death .
23398207	0	oxygen	80,86	Bcl-2	8,13	oxygen	Bcl-2	MESH:D010100	596	Chemical	Gene	pathway|compound|START_ENTITY autophagy|nmod|pathway induces|dobj|autophagy gossypol|acl:relcl|induces inhibitor|dep|gossypol inhibitor|compound|END_ENTITY	Natural Bcl-2 inhibitor -LRB- - -RRB- - _ gossypol induces protective autophagy via reactive oxygen species-high_mobility_group_box_1 pathway in Burkitt_lymphoma .
23621258	0	oxygen	67,73	Bcl-2	0,5	oxygen	Bcl-2	MESH:D010100	596	Chemical	Gene	species|compound|START_ENTITY generation|nmod|species inhibits|dobj|generation inhibits|nsubj|overexpression overexpression|amod|END_ENTITY	Bcl-2 overexpression inhibits generation of intracellular reactive oxygen species and blocks adriamycin-induced apoptosis in bladder_cancer cells .
25027422	0	oxygen	24,30	Bcl-2	67,72	oxygen	Bcl-2	MESH:D010100	596	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|nmod|END_ENTITY	-LSB- The effect of reactive oxygen species regulation of expression of Bcl-2 and Bax in apoptosis of human umbilical vein endothelial cell induced by heat stress -RSB- .
25971698	0	oxygen	101,107	Bcl-2	16,21	oxygen	Bcl-2	MESH:D010100	596	Chemical	Gene	deprived|nmod|START_ENTITY cells|acl|deprived enhances|nmod|cells enhances|nsubj|Upregulation Upregulation|nmod|END_ENTITY	Upregulation of Bcl-2 enhances secretion of growth factors by adipose-derived stem cells deprived of oxygen and glucose .
26173295	0	oxygen	101,107	Bcl-2	16,21	oxygen	Bcl-2	MESH:D010100	596	Chemical	Gene	deprived|nmod|START_ENTITY cells|acl|deprived enhances|nmod|cells enhances|nsubj|Upregulation Upregulation|nmod|END_ENTITY	Upregulation of Bcl-2 enhances secretion of growth factors by adipose-derived stem cells deprived of oxygen and glucose .
7599227	0	oxygen	9,15	Bcl-2	64,69	oxygen	Bcl-2	MESH:D010100	12043(Tax:10090)	Chemical	Gene	species|compound|START_ENTITY Reactive|dobj|species Reactive|nmod|family family|compound|END_ENTITY	Reactive oxygen species and the regulation of cell death by the Bcl-2 gene family .
9297559	0	oxygen	90,96	Bcl-2	0,5	oxygen	Bcl-2	MESH:D010100	596	Chemical	Gene	species|compound|START_ENTITY association|nmod|species cells|appos|association blocks|nmod|cells blocks|nsubj|END_ENTITY	Bcl-2 blocks peroxynitrite-induced apoptosis in HL-60 cells , an association with reactive oxygen species .
19227471	0	oxygen	35,41	C-peptide	22,31	oxygen	C-peptide	MESH:D010100	3630	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|nmod|transport	Effects of proinsulin C-peptide on oxygen transport , uptake and utilization in insulinopenic diabetic subjects -- a review .
22923476	0	oxygen	94,100	C-peptide	0,9	oxygen	C-peptide	MESH:D010100	3630	Chemical	Gene	activation|compound|START_ENTITY inhibition|nmod|activation prevents|nmod|inhibition prevents|nsubj|END_ENTITY	C-peptide prevents hyperglycemia-induced endothelial apoptosis through inhibition of reactive oxygen species-mediated transglutaminase_2 activation .
15378141	0	oxygen	29,35	C-reactive_protein	0,18	oxygen	C-reactive protein	MESH:D010100	1401	Chemical	Gene	START_ENTITY|nsubj|increases increases|amod|END_ENTITY	C-reactive_protein increases oxygen radical generation by neutrophils .
22906280	0	oxygen	32,38	C-reactive_protein	0,18	oxygen	C-reactive protein	MESH:D010100	1401	Chemical	Gene	metabolites|compound|START_ENTITY metabolites|amod|END_ENTITY	C-reactive_protein and reactive oxygen metabolites in subjects with metabolic_syndrome .
21199725	0	oxygen	9,15	CCL2	136,140	oxygen	CCL2	MESH:D010100	6347	Chemical	Gene	START_ENTITY|dep|secretion secretion|compound|END_ENTITY	Reactive oxygen species-activated p38/ERK 1/2 MAPK signaling pathway in the Mycobacterium_bovis bacillus Calmette Gu rin -LRB- BCG -RRB- - induced CCL2 secretion in human monocytic cell line THP-1 .
3377780	0	oxygen	33,39	CCl4	14,18	oxygen	CCl4	MESH:D010100	116637(Tax:10116)	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|amod|END_ENTITY	Inhibition of CCl4 metabolism by oxygen varies between isoenzymes of cytochrome_P-450 .
17977646	0	oxygen	13,19	CD133	31,36	oxygen	CD133	MESH:D010100	8842	Chemical	Gene	tension|compound|START_ENTITY tension|nmod|END_ENTITY	Influence of oxygen tension on CD133 phenotype in human glioma cell cultures .
10744228	0	oxygen	21,27	CD18	42,46	oxygen	CD18	MESH:D010100	309684(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of hyperbaric oxygen on neutrophil CD18 expression .
24318997	0	oxygen	28,34	CD44	70,74	oxygen	CD44	MESH:D010100	960	Chemical	Gene	species|compound|START_ENTITY suppress|nsubj|species suppress|dobj|END_ENTITY	Macrophage-derived reactive oxygen species suppress miR-328 targeting CD44 in cancer cells and promote redox adaptation .
26946213	0	oxygen	72,78	CD44	54,58	oxygen	CD44	MESH:D010100	960	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Hyaluronan coated cerium_oxide nanoparticles modulate CD44 and reactive oxygen species expression in human fibroblasts .
21956330	0	oxygen	31,37	CO2	62,65	oxygen	CO2	MESH:D010100	717	Chemical	Gene	isotopes|compound|START_ENTITY isotopes|nmod|END_ENTITY	Interannual variability in the oxygen isotopes of atmospheric CO2 driven by El Ni o .
3134787	0	oxygen	48,54	CO2	68,71	oxygen	CO2	MESH:D010100	717	Chemical	Gene	reactivity|compound|START_ENTITY reactivity|compound|END_ENTITY	Cerebral blood flow , cerebral metabolic rate of oxygen and relative CO2 reactivity during neurolept_anaesthesia in patients subjected to craniotomy for supratentorial_cerebral_tumours .
12418593	0	oxygen	10,16	COPD	108,112	oxygen	COPD	MESH:D010100	260431	Chemical	Gene	therapy|compound|START_ENTITY hospitalised|nsubj|therapy hospitalised|xcomp|due due|nmod|exacerbation exacerbation|nmod|END_ENTITY	Long-term oxygen therapy and quality of life in elderly patients hospitalised due to severe exacerbation of COPD .
16236854	0	oxygen	22,28	COPD	79,83	oxygen	COPD	MESH:D010100	260431	Chemical	Gene	production|compound|START_ENTITY intracellular|dobj|production intracellular|nmod|patients patients|amod|END_ENTITY	Reduced intracellular oxygen radical production in whole blood leukocytes from COPD patients and asymptomatic smokers .
23200590	0	oxygen	97,103	COPD	173,177	oxygen	COPD	MESH:D010100	260431	Chemical	Gene	therapy|compound|START_ENTITY due|nsubj|therapy due|nmod|END_ENTITY	-LSB- A multi-centre randomized controlled trial of domiciliary non-invasive ventilation vs long-term oxygen therapy in survivors of acute_hypercapnic_respiratory_failure due to COPD .
26557264	0	oxygen	68,74	COPD	35,39	oxygen	COPD	MESH:D010100	260431	Chemical	Gene	therapy|compound|START_ENTITY END_ENTITY|nmod|therapy	Outcomes of acute exacerbations in COPD in relation to pre-hospital oxygen therapy .
9926138	0	oxygen	75,81	COPD	44,48	oxygen	COPD	MESH:D010100	260431	Chemical	Gene	requirement|compound|START_ENTITY patients|nmod|requirement patients|nmod|practice practice|nmod|END_ENTITY	Screening patients in general practice with COPD for long-term domiciliary oxygen requirement using pulse oximetry .
16221213	0	oxygen	70,76	COX-2	28,33	oxygen	COX-2	MESH:D010100	29527(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY role|nmod|species Up-regulation|dep|role Up-regulation|nmod|END_ENTITY	Up-regulation of glomerular COX-2 by angiotensin_II : role of reactive oxygen species .
7034445	0	oxygen	26,32	CPAP	50,54	oxygen	CPAP	MESH:D010100	55835	Chemical	Gene	transport|compound|START_ENTITY transport|nmod|END_ENTITY	Central haemodynamics and oxygen transport during CPAP with and without mandatory ventilations .
24318796	0	oxygen	38,44	CP_47	12,17	oxygen	CP 47	MESH:D010100	8419	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of CP_47 in the evolution of oxygen and the binding of the extrinsic 33-kDa protein to the core complex of Photosystem II as determined by limited proteolysis .
18690522	0	oxygen	18,24	CXCL8	36,41	oxygen	CXCL8	MESH:D010100	3576	Chemical	Gene	species|compound|START_ENTITY species|nmod|END_ENTITY	Roles of reactive oxygen species in CXCL8 and CCL2 expression in response to the 30-kDa antigen of Mycobacterium_tuberculosis .
6296862	0	oxygen	28,34	CYC1	49,53	oxygen	CYC1	MESH:D010100	853507(Tax:4932)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Modulator sequences mediate oxygen regulation of CYC1 and a neighboring gene in yeast .
3037351	0	oxygen	21,27	CYC7	71,75	oxygen	CYC7	MESH:D010100	856672(Tax:4932)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|gene gene|compound|END_ENTITY	Elements involved in oxygen regulation of the Saccharomyces_cerevisiae CYC7 gene .
8772190	0	oxygen	70,76	Ca2	52,55	oxygen	Ca2	MESH:D010100	760	Chemical	Gene	intermediates|compound|START_ENTITY intermediates|amod|END_ENTITY	Activation of NF-kappa_B by ER stress requires both Ca2 + and reactive oxygen intermediates as messengers .
14695477	0	oxygen	65,71	Calcitonin_gene-related_peptide	0,31	oxygen	Calcitonin gene-related peptide	MESH:D010100	12310(Tax:10090)	Chemical	Gene	species|compound|START_ENTITY suppresses|dobj|species suppresses|nsubj|therapy therapy|amod|END_ENTITY	Calcitonin_gene-related_peptide gene therapy suppresses reactive oxygen species in the pancreas and prevents mice from autoimmune diabetes .
12948751	0	oxygen	91,97	Catalase	0,8	oxygen	Catalase	MESH:D010100	24248(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY induced|nmod|species induced|nsubj|derivatives derivatives|amod|END_ENTITY	Catalase and chondroitin_sulfate derivatives against thrombotic effect induced by reactive oxygen species in a rat artery .
16935793	0	oxygen	130,136	Catalase	0,8	oxygen	Catalase	MESH:D010100	847	Chemical	Gene	species|compound|START_ENTITY reactive|dobj|species exposed|xcomp|reactive fibroblasts|acl|exposed restores|nmod|fibroblasts restores|nsubj|END_ENTITY	Catalase restores the altered mRNA expression of collagen and matrix metalloproteinases by dermal fibroblasts exposed to reactive oxygen species .
19621736	0	oxygen	92,98	Catalase	1,9	oxygen	Catalase	MESH:D010100	12359(Tax:10090)	Chemical	Gene	-RSB-|compound|START_ENTITY rate|nmod|-RSB- correlations|nmod|rate END_ENTITY|dep|correlations	-LSB- Catalase and glutathione-peroxidase : qualitatively different correlations with the rate of oxygen consumption -RSB- .
21474567	0	oxygen	187,193	Catalase	0,8	oxygen	Catalase	MESH:D010100	847	Chemical	Gene	species|compound|START_ENTITY caused|nmod|species permeability|acl|caused alleviate|dobj|permeability alleviate|nsubj|antibody antibody|amod|END_ENTITY	Catalase and superoxide dismutase conjugated with platelet-endothelial cell adhesion molecule antibody distinctly alleviate abnormal endothelial permeability caused by exogenous reactive oxygen species and vascular_endothelial_growth_factor .
26314524	0	oxygen	29,35	Catalase	0,8	oxygen	Catalase	MESH:D010100	847	Chemical	Gene	species|compound|START_ENTITY eliminates|dobj|species eliminates|nsubj|END_ENTITY	Catalase eliminates reactive oxygen species and influences the intestinal microbiota of shrimp .
21832625	0	oxygen	9,15	CdO	59,62	oxygen	CdO	MESH:D010100	1036	Chemical	Gene	synthesis|compound|START_ENTITY synthesis|nmod|END_ENTITY	Reactive oxygen plasma-enabled synthesis of nanostructured CdO : tailoring nanostructures through plasma-surface interactions .
19494238	0	oxygen	19,25	Cdc42GAP	0,8	oxygen	Cdc42GAP	MESH:D010100	392	Chemical	Gene	species|compound|START_ENTITY END_ENTITY|appos|species	Cdc42GAP , reactive oxygen species , and the vimentin network .
1740238	0	oxygen	30,36	CuZn-superoxide_dismutase	54,79	oxygen	CuZn-superoxide dismutase	MESH:D010100	6647	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Relationship of resistance to oxygen free radicals to CuZn-superoxide_dismutase activity in transgenic , transfected , and trisomic cells .
16820798	0	oxygen	76,82	Cyclooxygenase-2	0,16	oxygen	Cyclooxygenase-2	MESH:D010100	19225(Tax:10090)	Chemical	Gene	species|compound|START_ENTITY production|nmod|species contribute|nmod|production contribute|nsubj|END_ENTITY	Cyclooxygenase-2 does not contribute to postischemic production of reactive oxygen species .
21164135	0	oxygen	37,43	Cyclooxygenase-2	0,16	oxygen	Cyclooxygenase-2	MESH:D010100	29527(Tax:10116)	Chemical	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	Cyclooxygenase-2 mediates hyperbaric oxygen preconditioning in the rat model of transient global cerebral_ischemia .
21193583	0	oxygen	87,93	Cytochrome_P-450	0,16	oxygen	Cytochrome P-450	MESH:D010100	13079(Tax:10090)	Chemical	Gene	constriction|nmod|START_ENTITY arteriosus|acl|constriction mediate|dobj|arteriosus mediate|nsubj|END_ENTITY	Cytochrome_P-450 3A13 and endothelin jointly mediate ductus arteriosus constriction to oxygen in mice .
6838544	0	oxygen	74,80	Cytochrome_P-450	0,16	oxygen	Cytochrome P-450	MESH:D010100	25251(Tax:10116)	Chemical	Gene	interaction|nmod|START_ENTITY mediated|dobj|interaction mediated|nsubj|END_ENTITY	Cytochrome_P-450 mediated interaction between hydroperoxide and molecular oxygen .
16452234	0	oxygen	157,163	DR5	198,201	oxygen	DR5	MESH:D010100	8795	Chemical	Gene	up-regulation|compound|START_ENTITY up-regulation|nmod|END_ENTITY	Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand -LRB- TRAIL -RRB- - resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of DR5 .
26056003	0	oxygen	37,43	DUOX2	56,61	oxygen	DUOX2	MESH:D010100	50506	Chemical	Gene	species|compound|START_ENTITY species|nmod|END_ENTITY	PKCa promotes generation of reactive oxygen species via DUOX2 in hepatocellular_carcinoma .
25925352	0	oxygen	34,40	E-selectin	0,10	oxygen	E-selectin	MESH:D010100	6401	Chemical	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	E-selectin , resistin and reactive oxygen species levels in GnRH - agonist and - antagonist protocols in IVF/ICSI : a prospective cohort study .
21708247	0	oxygen	33,39	EGFR	56,60	oxygen	EGFR	MESH:D010100	1956	Chemical	Gene	species|compound|START_ENTITY mediate|nsubj|species mediate|dobj|transactivation transactivation|amod|END_ENTITY	NADPH-oxidase-dependent reactive oxygen species mediate EGFR transactivation by FPRL1 in WKYMVm-stimulated human lung_cancer cells .
23872073	0	oxygen	87,93	EGFR	53,57	oxygen	EGFR	MESH:D010100	1956	Chemical	Gene	species|compound|START_ENTITY species|amod|END_ENTITY	Induction of renal fibrotic genes by TGF-b1 requires EGFR activation , p53 and reactive oxygen species .
24724551	0	oxygen	70,76	EGFR	20,24	oxygen	EGFR	MESH:D010100	1956	Chemical	Gene	species|compound|START_ENTITY mediated|nmod|species mediated|nsubjpass|Activation Activation|nmod|END_ENTITY	Activation of sperm EGFR by light irradiation is mediated by reactive oxygen species .
5391442	0	oxygen	26,32	ERG	36,39	oxygen	ERG	MESH:D010100	2078	Chemical	Gene	START_ENTITY|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- The effect of hyperbaric oxygen on ERG -RSB- .
10103024	0	oxygen	122,128	ERK	46,49	oxygen	ERK	MESH:D010100	5594	Chemical	Gene	induced|nmod|START_ENTITY pattern|acl|induced activation|dobj|pattern activation|nsubj|kinase kinase|dep|p38 p38|dep|JNK JNK|parataxis|END_ENTITY	Mitogen-activated protein kinase -LRB- p38 - , JNK - , ERK - -RRB- activation pattern induced by extracellular and intracellular singlet oxygen and UVA .
11483663	0	oxygen	49,55	ERK	13,16	oxygen	ERK	MESH:D010100	24338(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY mediated|nmod|species activation|acl|mediated activation|compound|END_ENTITY	Zn2 + - induced ERK activation mediated by reactive oxygen species causes cell death in differentiated PC12 cells .
11597988	0	oxygen	73,79	ERK	0,3	oxygen	ERK	MESH:D010100	5594	Chemical	Gene	induction|compound|START_ENTITY involved|nmod|induction involved|nsubj|END_ENTITY	ERK and p38 MAPK , but not NF-kappaB , are critically involved in reactive oxygen species-mediated induction of IL-6 by angiotensin_II in cardiac fibroblasts .
11709424	0	oxygen	17,23	ERK	66,69	oxygen	ERK	MESH:D010100	5594	Chemical	Gene	species|compound|START_ENTITY Role|nmod|species sustained|nsubj|Role sustained|dobj|activation activation|compound|END_ENTITY	Role of reactive oxygen species in IL-1_beta-stimulated sustained ERK activation and MMP-9 induction .
14623101	0	oxygen	148,154	ERK	34,37	oxygen	ERK	MESH:D010100	24338(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY formation|nmod|species activates|nmod|formation activates|dobj|kinase kinase|compound|END_ENTITY	Extracellular alkalosis activates ERK mitogen-activated protein kinase of vascular smooth muscle cells through NADPH-mediated formation of reactive oxygen species .
16328781	0	oxygen	11,17	ERK	50,53	oxygen	ERK	MESH:D010100	5594	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Hyperbaric oxygen induces VEGF expression through ERK , JNK and c-Jun/AP -1 activation in human umbilical vein endothelial cells .
18243549	0	oxygen	9,15	ERK	32,35	oxygen	ERK	MESH:D010100	24338(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY mediate|nsubj|species mediate|dobj|activation activation|compound|END_ENTITY	Reactive oxygen species mediate ERK activation through different Raf-1-dependent signaling pathways following cerebral_ischemia .
21059928	0	oxygen	32,38	ERK	111,114	oxygen	ERK	MESH:D010100	5594	Chemical	Gene	production|compound|START_ENTITY activates|nsubj|production activates|dobj|HIF-1 HIF-1|nmod|pathway pathway|compound|END_ENTITY	NADPH oxidase-mediated reactive oxygen species production activates hypoxia-inducible_factor-1 -LRB- HIF-1 -RRB- via the ERK pathway after hyperthermia treatment .
21229383	0	oxygen	67,73	ERK	141,144	oxygen	ERK	MESH:D010100	5594	Chemical	Gene	production|compound|START_ENTITY modulating|dobj|production hypersecretion|advcl|modulating mucous|acl|hypersecretion mucous|parataxis|signaling signaling|nsubj|MAPKinase MAPKinase|compound|END_ENTITY	Naringenin attenuates mucous hypersecretion by modulating reactive oxygen species production and inhibiting NF-kB activity via EGFR-PI3K-Akt / ERK MAPKinase signaling in human airway epithelial cells .
22961925	0	oxygen	9,15	ERK	46,49	oxygen	ERK	MESH:D010100	5594	Chemical	Gene	activation|compound|START_ENTITY activation|nmod|MAPK MAPK|compound|END_ENTITY	Reactive oxygen species-induced activation of ERK and p38 MAPK mediates PMA-induced NETs release from human neutrophils .
23490067	0	oxygen	97,103	ERK	122,125	oxygen	ERK	MESH:D010100	5594	Chemical	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Arachidonic_acid enhances TPA-induced differentiation in human leukemia HL-60 cells via reactive oxygen species-dependent ERK activation .
23957201	0	oxygen	100,106	ERK	38,41	oxygen	ERK	MESH:D010100	24338(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY lung_injury|acl|induced activation|nmod|lung_injury activation|compound|END_ENTITY	P38 activation is more important than ERK activation in lung_injury induced by prolonged hyperbaric oxygen .
25138434	0	oxygen	63,69	ERK	87,90	oxygen	ERK	MESH:D010100	5594	Chemical	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Quercetin induces mitochondrial-derived apoptosis via reactive oxygen species-mediated ERK activation in HL-60 leukemia cells and xenograft .
10233767	0	oxygen	61,67	ERK1/2	14,20	oxygen	ERK1/2	MESH:D010100	5595;5594	Chemical	Gene	species|compound|START_ENTITY pathways|nmod|species signaling|dobj|pathways activates|xcomp|signaling activates|dobj|END_ENTITY	UVB activates ERK1/2 and p38 signaling pathways via reactive oxygen species in cultured keratinocytes .
12860392	0	oxygen	137,143	ERK1/2	39,45	oxygen	ERK1/2	MESH:D010100	50689;116590	Chemical	Gene	species|compound|START_ENTITY formation|nmod|species peroxynitrite|nmod|formation mediated|nmod|peroxynitrite phosphorylation|acl|mediated phosphorylation|nummod|END_ENTITY	The Raf/MEK inhibitor PD98059 enhances ERK1/2 phosphorylation mediated by peroxynitrite via enforced mitochondrial formation of reactive oxygen species .
14755545	0	oxygen	62,68	ERK1/2	0,6	oxygen	ERK1/2	MESH:D010100	50689;116590	Chemical	Gene	induction|compound|START_ENTITY involved|nmod|induction involved|nsubjpass|END_ENTITY	ERK1/2 and JNKs , but not p38 kinase , are involved in reactive oxygen species-mediated induction of osteopontin gene expression by angiotensin_II and interleukin-1beta in adult rat cardiac fibroblasts .
15203192	0	oxygen	9,15	ERK1/2	67,73	oxygen	ERK1/2	MESH:D010100	5595;5594	Chemical	Gene	species|compound|START_ENTITY mediate|nsubj|species mediate|dobj|activation activation|nmod|PKB PKB|compound|END_ENTITY	Reactive oxygen species mediate Endothelin-1-induced activation of ERK1/2 , PKB , and Pyk2 signaling , as well as protein synthesis , in vascular smooth muscle cells .
16554353	0	oxygen	133,139	ERK1/2	158,164	oxygen	ERK1/2	MESH:D010100	50689;116590	Chemical	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	Chronic ethanol feeding increases activation of NADPH oxidase by lipopolysaccharide in rat Kupffer cells : role of increased reactive oxygen in LPS-stimulated ERK1/2 activation and TNF-alpha production .
16554353	0	oxygen	133,139	ERK1/2	158,164	oxygen	ERK1/2	MESH:D010100	50689;116590	Chemical	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	Chronic ethanol feeding increases activation of NADPH oxidase by lipopolysaccharide in rat Kupffer cells : role of increased reactive oxygen in LPS-stimulated ERK1/2 activation and TNF-alpha production .
16816114	0	oxygen	9,15	ERK1/2	78,84	oxygen	ERK1/2	MESH:D010100	5595;5594	Chemical	Gene	species|compound|START_ENTITY mediates|nsubj|species mediates|dobj|inhibition inhibition|nmod|END_ENTITY	Reactive oxygen species mediates disialoganglioside GD3-induced inhibition of ERK1/2 and matrix_metalloproteinase-9 expression in vascular smooth muscle cells .
17958324	0	oxygen	9,15	ERK1/2	59,65	oxygen	ERK1/2	MESH:D010100	5595;5594	Chemical	Gene	species|compound|START_ENTITY mediate|nsubj|species mediate|dobj|activation activation|nmod|END_ENTITY	Reactive oxygen species mediate ET-1-induced activation of ERK1/2 signaling in cultured feline esophageal smooth muscle cells .
18996496	0	oxygen	93,99	ERK1/2	29,35	oxygen	ERK1/2	MESH:D010100	5595;5594	Chemical	Gene	production|compound|START_ENTITY activation|nmod|production activation|compound|END_ENTITY	Docosahexaenoic_acid induces ERK1/2 activation and neuritogenesis via intracellular reactive oxygen species production in human neuroblastoma SH-SY5Y cells .
20105174	0	oxygen	62,68	ERK1/2	87,93	oxygen	ERK1/2	MESH:D010100	26417;26413	Chemical	Gene	signalling|compound|START_ENTITY signalling|compound|END_ENTITY	Tetrandrine blocks cardiac_hypertrophy by disrupting reactive oxygen species-dependent ERK1/2 signalling .
21510275	0	oxygen	55,61	ERK1/2	24,30	oxygen	ERK1/2	MESH:D010100	5595;5594	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Different activation of ERK1/2 and p38 with hyperbaric oxygen in dorsal root ganglion .
22956616	0	oxygen	9,15	ERK1/2	45,51	oxygen	ERK1/2	MESH:D010100	26417;26413	Chemical	Gene	species|compound|START_ENTITY regulate|nsubj|species regulate|dobj|signaling signaling|compound|END_ENTITY	Reactive oxygen species regulate prosurvival ERK1/2 signaling and bFGF expression in gliosis within the retina .
23338747	0	oxygen	61,67	ERK1/2	109,115	oxygen	ERK1/2	MESH:D010100	5595;5594	Chemical	Gene	species|compound|START_ENTITY increasing|iobj|species increasing|dobj|generation generation|nmod|END_ENTITY	Palmitate induces H9c2 cell apoptosis by increasing reactive oxygen species generation and activation of the ERK1/2 signaling pathway .
24442713	0	oxygen	32,38	ERK1/2	140,146	oxygen	ERK1/2	MESH:D010100	5595;5594	Chemical	Gene	species|compound|START_ENTITY promote|nsubj|species promote|nmod|heme_oxygenase-1 heme_oxygenase-1|nmod|pathways pathways|compound|END_ENTITY	Angiotensin_II-derived reactive oxygen species promote angiogenesis in human late endothelial progenitor cells through heme_oxygenase-1 via ERK1/2 and AKT/PI3K pathways .
24512724	0	oxygen	11,17	ERK1/2	91,97	oxygen	ERK1/2	MESH:D010100	50689;116590	Chemical	Gene	enlarges|nsubj|START_ENTITY enlarges|advcl|blocking blocking|nmod|activation activation|compound|END_ENTITY	Hyperbaric oxygen enlarges the area of brain_damage in MCAO rats by blocking autophagy via ERK1/2 activation .
24573389	0	oxygen	58,64	ERK1/2	14,20	oxygen	ERK1/2	MESH:D010100	50689;116590	Chemical	Gene	species|compound|START_ENTITY END_ENTITY|nmod|species	Activation of ERK1/2 by NADPH oxidase-originated reactive oxygen species mediates uric_acid-induced mesangial cell proliferation .
8060347	0	oxygen	4,10	ET-1	73,77	oxygen	ET-1	MESH:D010100	24323(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Low oxygen enhances endothelin-1 -LRB- ET-1 -RRB- production and responsiveness to ET-1 in cultured cardiac myocytes .
10807739	0	oxygen	88,94	Endothelin-1	0,12	oxygen	Endothelin-1	MESH:D010100	24323(Tax:10116)	Chemical	Gene	mechanism|compound|START_ENTITY kinase|nmod|mechanism induction|nmod|kinase cells|dep|induction cells|amod|END_ENTITY	Endothelin-1 and smooth muscle cells : induction of jun amino-terminal kinase through an oxygen radical-sensitive mechanism .
12193080	0	oxygen	78,84	Endothelin-1	0,12	oxygen	Endothelin-1	MESH:D010100	1906	Chemical	Gene	species|compound|START_ENTITY increased|nmod|species increased|nsubjpass|mRNA mRNA|amod|END_ENTITY	Endothelin-1 mRNA and protein in vascular wall cells is increased by reactive oxygen species .
15838313	0	oxygen	76,82	Endothelin-1	0,12	oxygen	Endothelin-1	MESH:D010100	24323(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY expression|nmod|species induces|dobj|expression induces|nsubj|END_ENTITY	Endothelin-1 induces cyclooxygenase-2 expression and generation of reactive oxygen species in endothelial cells .
16095180	0	oxygen	111,117	Endothelin-1	0,12	oxygen	Endothelin-1	MESH:D010100	281137(Tax:9913)	Chemical	Gene	treatment|compound|START_ENTITY association|nmod|treatment concentrations|dep|association concentrations|amod|END_ENTITY	Endothelin-1 concentrations in clone calves , their surrogate dams , and fetal fluids at birth : association with oxygen treatment .
16290054	0	oxygen	106,112	Endothelin-1	0,12	oxygen	Endothelin-1	MESH:D010100	24323(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY oxidase-derived|dobj|species H|acl|oxidase-derived involves|dobj|H involves|nsubj|activation activation|amod|END_ENTITY	Endothelin-1 activation of JAK2 in vascular smooth muscle cells involves NAD -LRB- P -RRB- H oxidase-derived reactive oxygen species .
8595934	0	oxygen	93,99	Endothelin-1	0,12	oxygen	Endothelin-1	MESH:D010100	1906	Chemical	Gene	metabolites|compound|START_ENTITY production|nmod|metabolites does|nmod|production does|nsubj|END_ENTITY	Endothelin-1 does not prime polymorphonuclear leukocytes for enhanced production of reactive oxygen metabolites .
9736447	0	oxygen	151,157	Endothelin-1	0,12	oxygen	Endothelin-1	MESH:D010100	1906	Chemical	Gene	chronic_respiratory_failure|nmod|START_ENTITY treatment|amod|chronic_respiratory_failure patients|nmod|treatment supplementation|nmod|patients oxygen|acl|supplementation circulating|nmod|oxygen END_ENTITY|acl|circulating	Endothelin-1 and NO2/NO3 circulating levels after short-term -LRB- 1h -RRB- oxygen supplementation in patients with chronic_respiratory_failure during long-term oxygen treatment -LRB- LTOT -RRB- .
9736447	0	oxygen	66,72	Endothelin-1	0,12	oxygen	Endothelin-1	MESH:D010100	1906	Chemical	Gene	circulating|nmod|START_ENTITY END_ENTITY|acl|circulating	Endothelin-1 and NO2/NO3 circulating levels after short-term -LRB- 1h -RRB- oxygen supplementation in patients with chronic_respiratory_failure during long-term oxygen treatment -LRB- LTOT -RRB- .
17573555	0	oxygen	74,80	Epidermal_growth_factor	0,23	oxygen	Epidermal growth factor	MESH:D010100	1950	Chemical	Gene	species|compound|START_ENTITY induced|nmod|species apoptosis|acl|induced rescues|dobj|apoptosis rescues|nsubj|END_ENTITY	Epidermal_growth_factor rescues trophoblast apoptosis induced by reactive oxygen species .
20473523	0	oxygen	35,41	Erk1/2	58,64	oxygen	Erk1/2	MESH:D010100	5595;5594	Chemical	Gene	induction|nmod|START_ENTITY species|nsubj|induction species|nmod|END_ENTITY	Differential induction of reactive oxygen species through Erk1/2 and Nox-1 by FK228 for selective apoptosis of oncogenic H-Ras-expressing human urinary_bladder_cancer J82 cells .
10422630	0	oxygen	49,55	Erythropoietin	0,14	oxygen	Erythropoietin	MESH:D010100	2056	Chemical	Gene	evidence|nmod|START_ENTITY production|dep|evidence production|compound|END_ENTITY	Erythropoietin production : evidence for multiple oxygen sensing pathways .
19260015	0	oxygen	50,56	Erythropoietin	0,14	oxygen	Erythropoietin	MESH:D010100	2056	Chemical	Gene	sensing|compound|START_ENTITY role|nmod|sensing END_ENTITY|dep|role	Erythropoietin and the skin : a role for epidermal oxygen sensing ?
20297691	0	oxygen	29,35	Erythropoietin	1,15	oxygen	Erythropoietin	MESH:D010100	100008786(Tax:9986)	Chemical	Gene	function|compound|START_ENTITY influence|nmod|function influence|nsubj|END_ENTITY	-LSB- Erythropoietin influence on oxygen transport function of blood and prooxidant/antioxidant balance in rabbits under lipopolysaccharide injection -RSB- .
20685070	0	oxygen	33,39	Erythropoietin	0,14	oxygen	Erythropoietin	MESH:D010100	2056	Chemical	Gene	generation|compound|START_ENTITY prevents|dobj|generation prevents|nsubj|END_ENTITY	Erythropoietin prevents reactive oxygen species generation and renal tubular cell apoptosis at high glucose level .
25669098	0	oxygen	39,45	Erythropoietin	1,15	oxygen	Erythropoietin	MESH:D010100	2056	Chemical	Gene	transport|compound|START_ENTITY influence|nmod|transport influence|nsubj|END_ENTITY	-LSB- Erythropoietin influence on the blood oxygen transport and prooxidant-antioxidant state during hepatic_ischemia-reperfusion -RSB- .
7969677	0	oxygen	75,81	Erythropoietin	0,14	oxygen	Erythropoietin	MESH:D010100	2056	Chemical	Gene	breathing|compound|START_ENTITY secretion|nmod|breathing secretion|nsubj|END_ENTITY	Erythropoietin secretion in patients with chronic_renal_failure after pure oxygen breathing .
8004661	0	oxygen	95,101	Erythropoietin	1,15	oxygen	Erythropoietin	MESH:D010100	2056	Chemical	Gene	-RSB-|compound|START_ENTITY secretion|nmod|-RSB- secretion|nsubj|END_ENTITY	-LSB- Erythropoietin secretion in patients with chronic_obstructive_lung_diseases during normobaric oxygen inhalation -RSB- .
9027736	0	oxygen	57,63	Erythropoietin	0,14	oxygen	Erythropoietin	MESH:D010100	2056	Chemical	Gene	sensing|compound|START_ENTITY depends|nmod|sensing depends|nsubj|regulation regulation|compound|END_ENTITY	Erythropoietin gene regulation depends on heme-dependent oxygen sensing and assembly of interacting transcription factors .
22829704	0	oxygen	92,98	Extracellular_signal-regulated_kinase	0,37	oxygen	Extracellular signal-regulated kinase	MESH:D010100	24338(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY podocytes|nmod|species treatment|amod|podocytes role|nmod|treatment plays|dobj|role plays|nsubj|END_ENTITY	Extracellular_signal-regulated_kinase plays a proapoptotic role in podocytes after reactive oxygen species treatment and inhibition of integrin-extracellular matrix interaction .
12051835	0	oxygen	47,53	FET4	39,43	oxygen	FET4	MESH:D010100	855369(Tax:4932)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of Saccharomyces_cerevisiae FET4 by oxygen and iron .
26499095	0	oxygen	79,85	FNR	20,23	oxygen	FNR	MESH:D010100	950327(Tax:71421)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A discrete role for FNR in the transcriptional response to moderate changes in oxygen by Haemophilus_influenzae Rd KW20 .
22139133	0	oxygen	26,32	FOXO3a	0,6	oxygen	FOXO3a	MESH:D010100	2309	Chemical	Gene	metabolism|compound|START_ENTITY regulates|dobj|metabolism regulates|nsubj|END_ENTITY	FOXO3a regulates reactive oxygen metabolism by inhibiting mitochondrial gene expression .
21708247	0	oxygen	33,39	FPRL1	80,85	oxygen	FPRL1	MESH:D010100	2358	Chemical	Gene	species|compound|START_ENTITY mediate|nsubj|species mediate|nmod|END_ENTITY	NADPH-oxidase-dependent reactive oxygen species mediate EGFR transactivation by FPRL1 in WKYMVm-stimulated human lung_cancer cells .
11514101	0	oxygen	87,93	Fas_ligand	15,25	oxygen	Fas ligand	MESH:D010100	356	Chemical	Gene	species|compound|START_ENTITY expression|nmod|species expression|nsubj|Suppression Suppression|nmod|END_ENTITY	Suppression of Fas_ligand expression on endothelial cells by arsenite through reactive oxygen species .
15087279	0	oxygen	117,123	Fas_ligand	41,51	oxygen	Fas ligand	MESH:D010100	356	Chemical	Gene	species|compound|START_ENTITY dependent|nmod|species mechanisms|amod|dependent cells|nmod|mechanisms induced|nmod|cells induced|nmod|expression expression|compound|END_ENTITY	Lipopolysaccharides induced increases in Fas_ligand expression by Kupffer cells via mechanisms dependent on reactive oxygen species .
24682485	0	oxygen	92,98	Fas_ligand	117,127	oxygen	Fas ligand	MESH:D010100	356	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Antibody ligation of CM1 on cisplatin-exposed HeLa cells induces apoptosis through reactive oxygen species-dependent Fas_ligand expression .
22977060	0	oxygen	35,41	Focal_adhesion_kinase	0,21	oxygen	Focal adhesion kinase	MESH:D010100	5747	Chemical	Gene	species|compound|START_ENTITY species|amod|END_ENTITY	Focal_adhesion_kinase and reactive oxygen species contribute to the persistent fibrotic phenotype of lesional scleroderma fibroblasts .
26867644	0	oxygen	96,102	GADD45	135,141	oxygen	GADD45	MESH:D010100	13197(Tax:10090)	Chemical	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Rhododenol and raspberry_ketone impair the normal proliferation of melanocytes through reactive oxygen species-dependent activation of GADD45 .
15640758	0	oxygen	22,28	GDNF	32,36	oxygen	GDNF	MESH:D010100	2668	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of hyperbaric oxygen on GDNF expression and apoptosis in spinal_cord_injury .
25101238	0	oxygen	40,46	GLUT1	8,13	oxygen	GLUT1	MESH:D010100	6513	Chemical	Gene	species|compound|START_ENTITY Role|nmod|species Role|nmod|END_ENTITY	Role of GLUT1 in regulation of reactive oxygen species .
20125115	0	oxygen	68,74	Granzyme_B	0,10	oxygen	Granzyme B	MESH:D010100	3002	Chemical	Gene	production|compound|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Granzyme_B of cytotoxic T cells induces extramitochondrial reactive oxygen species production via caspase-dependent NADPH oxidase activation .
2838478	0	oxygen	39,45	HEM13	59,64	oxygen	HEM13	MESH:D010100	851614(Tax:4932)	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Isolation , sequence , and regulation by oxygen of the yeast HEM13 gene coding for coproporphyrinogen_oxidase .
10847587	0	oxygen	107,113	HIF-1	28,33	oxygen	HIF-1	MESH:D010100	3091	Chemical	Gene	deprivation|compound|START_ENTITY lines|nmod|deprivation expression|nmod|lines expression|amod|factor-1 factor-1|dep|END_ENTITY	Hypoxia-inducible factor-1 -LRB- HIF-1 -RRB- up-regulates adrenomedullin expression in human tumor cell lines during oxygen deprivation : a possible promotion mechanism of carcinogenesis .
12719791	0	oxygen	9,15	HIF-1	33,38	oxygen	HIF-1	MESH:D010100	3091	Chemical	Gene	species|compound|START_ENTITY modulate|nsubj|species modulate|ccomp|mediated mediated|nsubj|END_ENTITY	Reactive oxygen species modulate HIF-1 mediated PAI-1 expression : involvement of the GTPase Rac1 .
14635664	0	oxygen	75,81	HIF-1	57,62	oxygen	HIF-1	MESH:D010100	3091	Chemical	Gene	species|compound|START_ENTITY END_ENTITY|nmod|species	Regulation of the hypoxia-inducible transcription factor HIF-1 by reactive oxygen species in smooth muscle cells .
14712080	0	oxygen	24,30	HIF-1	0,5	oxygen	HIF-1	MESH:D010100	3091	Chemical	Gene	relationship|nmod|START_ENTITY relationship|nmod:poss|END_ENTITY	HIF-1 's relationship to oxygen : simple yet sophisticated .
14726713	0	oxygen	10,16	HIF-1	0,5	oxygen	HIF-1	MESH:D010100	3091	Chemical	Gene	responsive|dep|START_ENTITY factor|amod|responsive END_ENTITY|dep|factor	HIF-1 : an oxygen and metal responsive transcription factor .
15304631	0	oxygen	24,30	HIF-1	17,22	oxygen	HIF-1	MESH:D010100	3091	Chemical	Gene	Hydroxylation|dep|START_ENTITY Hydroxylation|nmod|END_ENTITY	Hydroxylation of HIF-1 : oxygen sensing at the molecular level .
15618010	2	oxygen	182,188	HIF-1	162,167	oxygen	HIF-1	MESH:D010100	3091	Chemical	Gene	regulator|compound|START_ENTITY regulator|nsubj|Hypoxia-inducible_factor_1 Hypoxia-inducible_factor_1|appos|END_ENTITY	Hypoxia-inducible_factor_1 -LRB- HIF-1 -RRB- is the major oxygen homeostasis regulator .
16010420	1	oxygen	183,189	HIF-1	156,161	oxygen	HIF-1	MESH:D010100	3091	Chemical	Gene	tension|compound|START_ENTITY adapts|nmod|tension adapts|nsubj|factor factor|appos|END_ENTITY	The hypoxia-inducible transcription factor , HIF-1 , adapts cells to low oxygen tension .
16144688	0	oxygen	80,86	HIF-1	24,29	oxygen	HIF-1	MESH:D010100	3091	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|factors factors|amod|END_ENTITY	The interaction between HIF-1 and AP-1 transcription factors in response to low oxygen .
16144688	2	oxygen	453,459	HIF-1	559,564	oxygen	HIF-1	MESH:D010100	3091	Chemical	Gene	generated|nmod|START_ENTITY generated|nsubj|factors factors|acl:relcl|influenced influenced|nmod|activity activity|compound|END_ENTITY	As our understanding of the biology and biochemistry of HIF-1 has grown , it has become apparent that cells adapt to signals generated by low oxygen through a network of stress responsive transcription factors or complexes , which are influenced by HIF-1 activity .
16517402	0	oxygen	43,49	HIF-1	19,24	oxygen	HIF-1	MESH:D010100	3091	Chemical	Gene	consumption|compound|START_ENTITY consumption|amod|END_ENTITY	Coming up for air : HIF-1 and mitochondrial oxygen consumption .
16517406	0	oxygen	78,84	HIF-1	0,5	oxygen	HIF-1	MESH:D010100	3091	Chemical	Gene	consumption|compound|START_ENTITY downregulating|dobj|consumption mediates|advcl|downregulating mediates|nsubj|END_ENTITY	HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption .
21059928	0	oxygen	32,38	HIF-1	96,101	oxygen	HIF-1	MESH:D010100	3091	Chemical	Gene	production|compound|START_ENTITY activates|nsubj|production activates|dobj|END_ENTITY	NADPH oxidase-mediated reactive oxygen species production activates hypoxia-inducible_factor-1 -LRB- HIF-1 -RRB- via the ERK pathway after hyperthermia treatment .
21093262	0	oxygen	68,74	HIF-1	97,102	oxygen	HIF-1	MESH:D010100	180359(Tax:6239)	Chemical	Gene	species|compound|START_ENTITY span|nmod|species span|acl:relcl|increase increase|dobj|activity activity|compound|END_ENTITY	Inhibition of respiration extends C. _ elegans life span via reactive oxygen species that increase HIF-1 activity .
22360728	0	oxygen	17,23	HIF-1	53,58	oxygen	HIF-1	MESH:D010100	3091	Chemical	Gene	species|compound|START_ENTITY Role|nmod|species Role|nmod|regulation regulation|nmod|END_ENTITY	Role of reactive oxygen species in the regulation of HIF-1 by prolyl_hydroxylase_2 under mild hypoxia .
26899267	0	oxygen	42,48	HIF-1	36,41	oxygen	HIF-1	MESH:D010100	3091	Chemical	Gene	mechanism|compound|START_ENTITY mechanism|compound|END_ENTITY	Melatonin and the von_Hippel-Lindau / HIF-1 oxygen sensing mechanism : A review .
21633368	0	oxygen	21,27	HIF-1a	0,6	oxygen	HIF-1a	MESH:D010100	3091	Chemical	Gene	sensing|compound|START_ENTITY END_ENTITY|dep|sensing	HIF-1a in epidermis : oxygen sensing , cutaneous angiogenesis , cancer , and non-cancer_disorders .
22100406	0	oxygen	68,74	HIF-1a	51,57	oxygen	HIF-1a	MESH:D010100	15251(Tax:10090)	Chemical	Gene	consumption|compound|START_ENTITY decreases|dobj|consumption decreases|nsubj|Induction Induction|nmod|protein protein|nmod|END_ENTITY	Induction of the mitochondrial NDUFA4L2 protein by HIF-1a decreases oxygen consumption by inhibiting Complex I activity .
22162090	0	oxygen	64,70	HIF-1a	46,52	oxygen	HIF-1a	MESH:D010100	15251(Tax:10090)	Chemical	Gene	consumption|compound|START_ENTITY regulating|dobj|consumption END_ENTITY|acl|regulating	VEGF-independent cell-autonomous functions of HIF-1a regulating oxygen consumption in fetal cartilage are critical for chondrocyte survival .
22773957	2	oxygen	280,286	HIF-1a	362,368	oxygen	HIF-1a	MESH:D010100	3091	Chemical	Gene	alteration|compound|START_ENTITY adapted|nmod|alteration process|acl|adapted depends|nsubj|process depends|nmod|regulation regulation|nmod|subunit subunit|appos|END_ENTITY	The fundamental process adapted to cellular oxygen alteration largely depends on the refined regulation on its alpha subunit , HIF-1a .
23232974	0	oxygen	11,17	HIF-1a	39,45	oxygen	HIF-1a	MESH:D010100	15251(Tax:10090)	Chemical	Gene	tension|compound|START_ENTITY Effects|nmod|tension Effects|nmod|expression expression|compound|END_ENTITY	Effects of oxygen tension and IGF-I on HIF-1a protein expression in mouse blastocysts .
23840849	0	oxygen	96,102	HIF-1a	123,129	oxygen	HIF-1a	MESH:D010100	3091	Chemical	Gene	tension|compound|START_ENTITY changes|nmod|tension response|nmod|changes cells|nmod|response bioenergetics|nmod|cells bioenergetics|dep|effects effects|nmod|END_ENTITY	Mitochondrial bioenergetics of metastatic breast_cancer cells in response to dynamic changes in oxygen tension : effects of HIF-1a .
23988581	0	oxygen	37,43	HIF-1a	55,61	oxygen	HIF-1a	MESH:D010100	3091	Chemical	Gene	species|compound|START_ENTITY Effects|nmod|species Effects|nmod|stabilization stabilization|compound|END_ENTITY	Effects of nitric_oxide and reactive oxygen species on HIF-1a stabilization following clostridium_difficile toxin exposure of the Caco-2 epithelial cell line .
24835245	0	oxygen	88,94	HIF-1a	16,22	oxygen	HIF-1a	MESH:D010100	29560(Tax:10116)	Chemical	Gene	tensions|compound|START_ENTITY division|nmod|tensions factor|nmod|division factor|compound|END_ENTITY	The role of the HIF-1a transcription factor in increased cell division at physiological oxygen tensions .
24992925	0	oxygen	145,151	HIF-1a	177,183	oxygen	HIF-1a	MESH:D010100	29560(Tax:10116)	Chemical	Gene	conditions|compound|START_ENTITY cultured|nmod|conditions cultured|advcl|inhibiting inhibiting|dobj|END_ENTITY	Methylprednisolone inhibits the proliferation and affects the differentiation of rat spinal cord-derived neural progenitor cells cultured in low oxygen conditions by inhibiting HIF-1a and Hes1 in vitro .
25174950	0	oxygen	9,15	HIF-1a	67,73	oxygen	HIF-1a	MESH:D010100	3091	Chemical	Gene	species|compound|START_ENTITY promote|nsubj|species promote|dobj|progression progression|nmod|pathway pathway|compound|END_ENTITY	Reactive oxygen species promote ovarian_cancer progression via the HIF-1a / LOX/E-cadherin pathway .
25754172	0	oxygen	145,151	HIF-1a	44,50	oxygen	HIF-1a	MESH:D010100	15251(Tax:10090)	Chemical	Gene	control|nmod|START_ENTITY independent|parataxis|control independent|nmod|END_ENTITY	Kidney_injury is independent of endothelial HIF-1a UNASSIGNED : Hypoxia-inducible transcription factors -LRB- HIFs -RRB- control cellular adaptation to low oxygen .
26621849	0	oxygen	86,92	HIF-1a	54,60	oxygen	HIF-1a	MESH:D010100	3091	Chemical	Gene	metabolism|compound|START_ENTITY reprogramming|nmod|metabolism suppresses|advcl|reprogramming suppresses|dobj|stabilization stabilization|nmod|END_ENTITY	Metformin suppresses hypoxia-induced stabilization of HIF-1a through reprogramming of oxygen metabolism in hepatocellular_carcinoma .
26872098	0	oxygen	11,17	HIF-1a	35,41	oxygen	HIF-1a	MESH:D010100	29560(Tax:10116)	Chemical	Gene	therapy|compound|START_ENTITY inhibits|nsubj|therapy inhibits|dobj|expression expression|amod|END_ENTITY	Normobaric oxygen therapy inhibits HIF-1a and VEGF expression in perihematoma and reduces neurological function defects .
26996298	0	oxygen	85,91	HIF-1a	49,55	oxygen	HIF-1a	MESH:D010100	3091	Chemical	Gene	subjected|nmod|START_ENTITY cells|acl|subjected END_ENTITY|nmod|cells	Leptin contributes to long-term stabilization of HIF-1a in cancer cells subjected to oxygen limiting conditions .
12912907	0	oxygen	36,42	HIF-1alpha	85,95	oxygen	HIF-1alpha	MESH:D010100	3091	Chemical	Gene	sensor|compound|START_ENTITY sensor|acl|setting setting|dobj|levels levels|nmod|END_ENTITY	HIF_prolyl-hydroxylase_2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia .
14657004	0	oxygen	26,32	HIF-1alpha	117,127	oxygen	HIF-1alpha	MESH:D010100	3091	Chemical	Gene	species|compound|START_ENTITY exert|nsubj|species exert|xcomp|opposing opposing|nmod|stability stability|nmod|END_ENTITY	Nitric_oxide and reactive oxygen species exert opposing effects on the stability of hypoxia-inducible_factor-1alpha -LRB- HIF-1alpha -RRB- in explants of human pial arteries .
14971644	0	oxygen	68,74	HIF-1alpha	17,27	oxygen	HIF-1alpha	MESH:D010100	3091	Chemical	Gene	species|compound|START_ENTITY induces|nmod|species induces|dobj|END_ENTITY	Arsenite induces HIF-1alpha and VEGF through PI3K , Akt and reactive oxygen species in DU145 human prostate_carcinoma cells .
15492505	3	oxygen	479,485	HIF-1alpha	324,334	oxygen	HIF-1alpha	MESH:D010100	3091	Chemical	Gene	concentrations|compound|START_ENTITY enzymes|nmod|concentrations activity|nmod|enzymes achieved|nmod|activity hydroxylation|acl:relcl|achieved inhibition|nmod|hydroxylation result|nmod|inhibition stabilized|nmod|result stabilized|nsubjpass|END_ENTITY	In hypoxia , HIF-1alpha is stabilized as a result of inhibition of HIF-1alpha hydroxylation , which in part is achieved by decreased activity of PHD enzymes at very low oxygen concentrations .
15862307	0	oxygen	72,78	HIF-1alpha	115,125	oxygen	HIF-1alpha	MESH:D010100	3091	Chemical	Gene	species|compound|START_ENTITY species|nmod|signaling signaling|nmod|END_ENTITY	A targeted antioxidant reveals the importance of mitochondrial reactive oxygen species in the hypoxic signaling of HIF-1alpha .
16140212	0	oxygen	70,76	HIF-1alpha	12,22	oxygen	HIF-1alpha	MESH:D010100	3091	Chemical	Gene	species|compound|START_ENTITY role|nmod|species hydroxylation|dep|role hydroxylation|compound|END_ENTITY	NO restores HIF-1alpha hydroxylation during hypoxia : role of reactive oxygen species .
16507596	0	oxygen	112,118	HIF-1alpha	74,84	oxygen	HIF-1alpha	MESH:D010100	15251(Tax:10090)	Chemical	Gene	species|compound|START_ENTITY species|amod|END_ENTITY	Regulation of cardiotrophin-1 expression in mouse embryonic stem cells by HIF-1alpha and intracellular reactive oxygen species .
16753841	0	oxygen	41,47	HIF-1alpha	51,61	oxygen	HIF-1alpha	MESH:D010100	3091	Chemical	Gene	donor|nmod|START_ENTITY Peroxynitrite|nmod|donor Peroxynitrite|nmod|hydroxylation hydroxylation|compound|END_ENTITY	Peroxynitrite as an alternative donor of oxygen in HIF-1alpha proline hydroxylation under low oxygen availability .
16753841	0	oxygen	94,100	HIF-1alpha	51,61	oxygen	HIF-1alpha	MESH:D010100	3091	Chemical	Gene	availability|compound|START_ENTITY hydroxylation|nmod|availability hydroxylation|compound|END_ENTITY	Peroxynitrite as an alternative donor of oxygen in HIF-1alpha proline hydroxylation under low oxygen availability .
17272744	0	oxygen	9,15	HIF-1alpha	37,47	oxygen	HIF-1alpha	MESH:D010100	3091	Chemical	Gene	species|compound|START_ENTITY activate|nsubj|species activate|dobj|promoter promoter|compound|END_ENTITY	Reactive oxygen species activate the HIF-1alpha promoter via a functional NFkappaB site .
17666400	0	oxygen	110,116	HIF-1alpha	166,176	oxygen	HIF-1alpha	MESH:D010100	3091	Chemical	Gene	concentration|compound|START_ENTITY response|nmod|concentration response|dep|implications implications|nmod|mechanism mechanism|nmod|stabilization stabilization|compound|END_ENTITY	Detection of reactive oxygen species via endogenous oxidative pentose_phosphate cycle activity in response to oxygen concentration : implications for the mechanism of HIF-1alpha stabilization under moderate hypoxia .
17666400	0	oxygen	22,28	HIF-1alpha	166,176	oxygen	HIF-1alpha	MESH:D010100	3091	Chemical	Gene	species|compound|START_ENTITY Detection|nmod|species oxidative|nsubj|Detection oxidative|nmod|response response|dep|implications implications|nmod|mechanism mechanism|nmod|stabilization stabilization|compound|END_ENTITY	Detection of reactive oxygen species via endogenous oxidative pentose_phosphate cycle activity in response to oxygen concentration : implications for the mechanism of HIF-1alpha stabilization under moderate hypoxia .
18439571	0	oxygen	83,89	HIF-1alpha	13,23	oxygen	HIF-1alpha	MESH:D010100	15251(Tax:10090)	Chemical	Gene	preconditioning|compound|START_ENTITY induced|nmod|preconditioning tolerance|acl|induced involved|nmod|tolerance involved|nsubjpass|END_ENTITY	Up-regulated HIF-1alpha is involved in the hypoxic tolerance induced by hyperbaric oxygen preconditioning .
18473128	0	oxygen	94,100	HIF-1alpha	31,41	oxygen	HIF-1alpha	MESH:D010100	3091	Chemical	Gene	species|compound|START_ENTITY generation|nmod|species regulates|nmod|generation regulates|dobj|levels levels|compound|END_ENTITY	Thrombopoietin -LRB- TPO -RRB- regulates HIF-1alpha levels through generation of mitochondrial reactive oxygen species .
18771709	0	oxygen	115,121	HIF-1alpha	37,47	oxygen	HIF-1alpha	MESH:D010100	15251(Tax:10090)	Chemical	Gene	species|compound|START_ENTITY inhibition|nmod|species suppresses|nmod|inhibition suppresses|dobj|accumulation accumulation|compound|END_ENTITY	Baicalein suppresses hypoxia-induced HIF-1alpha protein accumulation and activation through inhibition of reactive oxygen species and PI 3-kinase/Akt pathway in BV2 murine microglial cells .
19587783	0	oxygen	57,63	HIF-1alpha	24,34	oxygen	HIF-1alpha	MESH:D010100	3091	Chemical	Gene	tension|compound|START_ENTITY induced|nmod|tension modulation|acl|induced modulation|compound|END_ENTITY	Molecular mechanisms of HIF-1alpha modulation induced by oxygen tension and BMP2 in glioblastoma derived cells .
19893619	0	oxygen	93,99	HIF-1alpha	14,24	oxygen	HIF-1alpha	MESH:D010100	3091	Chemical	Gene	concentration|compound|START_ENTITY alteration|nmod|concentration adapt|nmod|alteration Regulation|acl|adapt Regulation|nmod|cells cells|amod|END_ENTITY	Regulation of HIF-1alpha and VEGF by miR-20b tunes tumor cells to adapt to the alteration of oxygen concentration .
18711622	0	oxygen	90,96	HIF2A	72,77	oxygen	HIF2A	MESH:D010100	2034	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Familial_erythrocytosis arising from a gain-of-function mutation in the HIF2A gene of the oxygen sensing pathway .
23361906	0	oxygen	30,36	HIF2A	6,11	oxygen	HIF2A	MESH:D010100	2034	Chemical	Gene	sensing|compound|START_ENTITY sensing|amod|disrupt disrupt|nmod:npmod|mutations mutations|nummod|END_ENTITY	Novel HIF2A mutations disrupt oxygen sensing , leading to polycythemia , paragangliomas , and somatostatinomas .
12912907	0	oxygen	36,42	HIF_prolyl-hydroxylase_2	0,24	oxygen	HIF prolyl-hydroxylase 2	MESH:D010100	54583	Chemical	Gene	sensor|compound|START_ENTITY sensor|nsubj|END_ENTITY	HIF_prolyl-hydroxylase_2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia .
18336854	0	oxygen	9,15	HSP90	34,39	oxygen	HSP90	MESH:D010100	111042(Tax:10090)	Chemical	Gene	cleavage|compound|START_ENTITY cleavage|compound|END_ENTITY	Reactive oxygen species-dependent HSP90 protein cleavage participates in arsenical As -LRB- +3 -RRB- - and MMA -LRB- +3 -RRB- - induced apoptosis through inhibition of telomerase activity via JNK activation .
16678019	0	oxygen	110,116	Heme_oxygenase-1	0,16	oxygen	Heme oxygenase-1	MESH:D010100	24451(Tax:10116)	Chemical	Gene	generation|compound|START_ENTITY down-regulation|nmod|generation cells|nmod|down-regulation apoptosis|nmod|cells attenuates|dobj|apoptosis attenuates|nsubj|END_ENTITY	Heme_oxygenase-1 attenuates the cisplatin-induced apoptosis of auditory cells via down-regulation of reactive oxygen species generation .
18665050	0	oxygen	64,70	Heme_oxygenase-1	0,16	oxygen	Heme oxygenase-1	MESH:D010100	15368(Tax:10090)	Chemical	Gene	carrier|compound|START_ENTITY macrophages|nmod|carrier induction|nmod|macrophages induction|amod|END_ENTITY	Heme_oxygenase-1 induction in macrophages by a hemoglobin-based oxygen carrier reduces endotoxin-stimulated cytokine secretion .
21564546	0	oxygen	86,92	Heme_oxygenase-1	0,16	oxygen	Heme oxygenase-1	MESH:D010100	100682424	Chemical	Gene	homeostasis|compound|START_ENTITY modulating|dobj|homeostasis associated|advcl|modulating associated|nsubjpass|END_ENTITY	Heme_oxygenase-1 is associated with wheat salinity acclimation by modulating reactive oxygen species homeostasis .
22231145	0	oxygen	130,136	Heme_oxygenase_1	0,16	oxygen	Heme oxygenase 1	MESH:D010100	15368(Tax:10090)	Chemical	Gene	species/activator|compound|START_ENTITY decrease|nmod|species/activator expression|nmod|decrease attenuates|dobj|expression attenuates|nsubj|END_ENTITY	Heme_oxygenase_1 attenuates interleukin-1b-induced cytosolic_phospholipase_A2 expression via a decrease in NADPH oxidase/reactive oxygen species/activator _ protein_1 activation in rheumatoid_arthritis synovial fibroblasts .
12230876	0	oxygen	58,64	Heparin-binding_EGF-like_growth_factor	0,38	oxygen	Heparin-binding EGF-like growth factor	MESH:D010100	25433(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY decreases|dobj|production decreases|nsubj|END_ENTITY	Heparin-binding_EGF-like_growth_factor -LRB- HB-EGF -RRB- decreases oxygen free radical production in vitro and in vivo .
15978632	0	oxygen	55,61	Hsp70	25,30	oxygen	Hsp70	MESH:D010100	3308	Chemical	Gene	species|compound|START_ENTITY expression|nmod|species expression|amod|END_ENTITY	Arsenic_trioxide induces Hsp70 expression via reactive oxygen species and JNK pathway in MDA231 cells .
21481276	0	oxygen	97,103	Hypoxia-Inducible_Factor-1a	20,47	oxygen	Hypoxia-Inducible Factor-1a	MESH:D010100	3091	Chemical	Gene	availability|compound|START_ENTITY regulating|dobj|availability prevents|advcl|regulating prevents|dobj|stabilization stabilization|compound|END_ENTITY	Compound C prevents Hypoxia-Inducible_Factor-1a protein stabilization by regulating the cellular oxygen availability via interaction with Mitochondrial Complex I .
10712429	0	oxygen	62,68	Hypoxia-inducible_factor-1	0,26	oxygen	Hypoxia-inducible factor-1	MESH:D010100	3091	Chemical	Gene	effects|nmod|START_ENTITY mediates|dobj|effects mediates|nsubj|END_ENTITY	Hypoxia-inducible_factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta -LRB- 3 -RRB- During early pregnancy , placentation occurs in a relatively hypoxic environment that is essential for appropriate embryonic development .
20660157	0	oxygen	117,123	Hypoxia-inducible_factor-1	0,26	oxygen	Hypoxia-inducible factor-1	MESH:D010100	3091	Chemical	Gene	species|compound|START_ENTITY role|nmod|species activation|dep|role activation|amod|END_ENTITY	Hypoxia-inducible_factor-1 activation in nonhypoxic conditions : the essential role of mitochondrial-derived reactive oxygen species .
10362686	0	oxygen	13,19	ICAM-1	52,58	oxygen	ICAM-1	MESH:D010100	3383	Chemical	Gene	tension|compound|START_ENTITY Increases|nmod|tension stimulate|nsubj|Increases stimulate|dobj|expression expression|nmod|END_ENTITY	Increases in oxygen tension stimulate expression of ICAM-1 and VCAM-1 on human endothelial cells .
10843706	0	oxygen	110,116	ICAM-1	90,96	oxygen	ICAM-1	MESH:D010100	3383	Chemical	Gene	species|compound|START_ENTITY species|amod|END_ENTITY	Neutrophil-induced changes in the biomechanical properties of endothelial cells : roles of ICAM-1 and reactive oxygen species .
10891397	0	oxygen	21,27	ICAM-1	80,86	oxygen	ICAM-1	MESH:D010100	3383	Chemical	Gene	role|nmod|START_ENTITY intermediates|nsubj|role intermediates|nmod|regulation regulation|nmod|expression expression|compound|END_ENTITY	The role of reactive oxygen intermediates in the regulation of cytokine-induced ICAM-1 surface expression on endothelial cells .
20079413	0	oxygen	87,93	ICAM-1	13,19	oxygen	ICAM-1	MESH:D010100	3383	Chemical	Gene	species|compound|START_ENTITY generation|nmod|species mediated|nmod|generation mediated|nsubjpass|Induction Induction|nmod|mellea mellea|amod|END_ENTITY	Induction of ICAM-1 by Armillariella mellea is mediated through generation of reactive oxygen species and JNK activation .
7513210	0	oxygen	9,15	ICAM-1	53,59	oxygen	ICAM-1	MESH:D010100	3383	Chemical	Gene	species|compound|START_ENTITY increase|nsubj|species increase|dobj|ability ability|compound|END_ENTITY	Reactive oxygen species rapidly increase endothelial ICAM-1 ability to bind neutrophils without detectable upregulation .
8104435	5	oxygen	919,925	ICAM-1	863,869	oxygen	ICAM-1	MESH:D010100	15894(Tax:10090)	Chemical	Gene	>|dobj|START_ENTITY exposed|xcomp|> mice|acl|exposed lungs|nmod|mice investigating|nmod|lungs investigating|dobj|expression expression|compound|END_ENTITY	The purpose of this study was to examine the role of inflammation in hyperoxia-induced lung_injury by investigating ICAM-1 expression in the lungs of mice exposed to > 95 % oxygen continuously .
8596125	0	oxygen	42,48	ICAM-1	16,22	oxygen	ICAM-1	MESH:D010100	3383	Chemical	Gene	intermediates|compound|START_ENTITY intermediates|amod|END_ENTITY	Upregulation of ICAM-1 , IL-1 and reactive oxygen intermediates -LRB- ROI -RRB- by exogenous antigens from Plasmodium_falciparum parasites in vitro , and of sICAM-1 in the acute phase of malaria .
9350418	0	oxygen	55,61	ICAM-1	112,118	oxygen	ICAM-1	MESH:D010100	3383	Chemical	Gene	intermediates|compound|START_ENTITY generation|nmod|intermediates Ionizing|dep|generation Ionizing|dep|intercellular_adhesion_molecule-1 intercellular_adhesion_molecule-1|appos|END_ENTITY	Ionizing radiation induces , via generation of reactive oxygen intermediates , intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- gene transcription and NF_kappa_B-like binding activity in the ICAM-1 transcriptional regulatory region .
9451527	0	oxygen	21,27	ICAM-1	66,72	oxygen	ICAM-1	MESH:D010100	15894(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|appos|END_ENTITY	Effect of hyperbaric oxygen on intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression in murine lung .
20661932	0	oxygen	33,39	IL-1b	106,111	oxygen	IL-1b	MESH:D010100	3553	Chemical	Gene	effects|nmod|START_ENTITY degenerated|nsubj|effects degenerated|dobj|cells cells|nmod|suppression suppression|nmod|signal signal|compound|END_ENTITY	Beneficial effects of hyperbaric oxygen on human degenerated intervertebral disk cells via suppression of IL-1b and p38 MAPK signal .
23963575	0	oxygen	31,37	IL-1b	79,84	oxygen	IL-1b	MESH:D010100	3553	Chemical	Gene	species|compound|START_ENTITY involved|nsubjpass|species involved|nmod|secretion secretion|compound|END_ENTITY	NADPH oxidase derived reactive oxygen species are involved in human neutrophil IL-1b secretion but not in inflammasome activation .
24577006	0	oxygen	130,136	IL-1b	111,116	oxygen	IL-1b	MESH:D010100	16176(Tax:10090)	Chemical	Gene	species|compound|START_ENTITY species|amod|END_ENTITY	IFN-y impairs Trichophyton_rubrum proliferation in a murine model of dermatophytosis through the production of IL-1b and reactive oxygen species .
26959386	0	oxygen	138,144	IL-1b	30,35	oxygen	IL-1b	MESH:D010100	3553	Chemical	Gene	species|compound|START_ENTITY inflammasome|nmod|species activating|dobj|inflammasome induces|advcl|activating induces|dobj|production production|compound|END_ENTITY	Trichomonas_vaginalis induces IL-1b production in a human prostate epithelial cell line by activating the NLRP3 inflammasome via reactive oxygen species and potassium ion efflux .
11577997	0	oxygen	115,121	IL-1beta	81,89	oxygen	IL-1beta	MESH:D010100	281251(Tax:9913)	Chemical	Gene	species|compound|START_ENTITY involvement|nmod|species activation|dep|involvement activation|acl|induced induced|nmod|END_ENTITY	Diphenyleneiodonium inhibits NF-kappaB activation and iNOS expression induced by IL-1beta : involvement of reactive oxygen species .
12387824	0	oxygen	36,42	IL-1beta	0,8	oxygen	IL-1beta	MESH:D010100	16176(Tax:10090)	Chemical	Gene	species|compound|START_ENTITY MMP-9|nmod|species induces|dobj|MMP-9 induces|nsubj|END_ENTITY	IL-1beta induces MMP-9 via reactive oxygen species and NF-kappaB in murine macrophage RAW 264.7 cells .
14566967	6	oxygen	912,918	IL-1beta	1004,1012	oxygen	IL-1beta	MESH:D010100	3553	Chemical	Gene	species|compound|START_ENTITY scavenger|nmod|species Pyrrolidine_dithiocarbamate|appos|scavenger blocked|nsubj|Pyrrolidine_dithiocarbamate blocked|nmod|END_ENTITY	Pyrrolidine_dithiocarbamate -LRB- PDTC -RRB- , a scavenger of reactive oxygen species -LRB- ROS -RRB- blocked apoptosis induction by CH-11 / PSI as well as the enhancement by IL-1beta .
14651966	0	oxygen	92,98	IL-1beta	20,28	oxygen	IL-1beta	MESH:D010100	24494(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY regulated|nmod|species regulated|nsubjpass|END_ENTITY	Plasminogen-induced IL-1beta and TNF-alpha production in microglia is regulated by reactive oxygen species .
19949838	0	oxygen	84,90	IL-1beta	0,8	oxygen	IL-1beta	MESH:D010100	24494(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY channels|nmod|species Ca|dep|channels modulate|dobj|Ca modulate|nsubj|END_ENTITY	IL-1beta modulate the Ca -LRB- 2 + -RRB- - activated big-conductance K channels -LRB- BK -RRB- via reactive oxygen species in cultured rat aorta smooth muscle cells .
20059972	0	oxygen	157,163	IL-1beta	45,53	oxygen	IL-1beta	MESH:D010100	3553	Chemical	Gene	species|compound|START_ENTITY mediated|nmod|species levels|acl|mediated levels|nmod|production production|compound|END_ENTITY	Titanium_dioxide induces different levels of IL-1beta production dependent on its particle characteristics through caspase-1 activation mediated by reactive oxygen species and cathepsin_B .
20133696	0	oxygen	9,15	IL-1beta	54,62	oxygen	IL-1beta	MESH:D010100	3553	Chemical	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Reactive oxygen species-independent activation of the IL-1beta inflammasome in cells from patients with chronic_granulomatous_disease .
19067841	0	oxygen	18,24	IL-4	0,4	oxygen	IL-4	MESH:D010100	3565	Chemical	Gene	species|compound|START_ENTITY species|compound|END_ENTITY	IL-4 and reactive oxygen species are elevated in Egyptian patients affected with schistosomal_liver_disease .
11597988	0	oxygen	73,79	IL-6	110,114	oxygen	IL-6	MESH:D010100	3569	Chemical	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	ERK and p38 MAPK , but not NF-kappaB , are critically involved in reactive oxygen species-mediated induction of IL-6 by angiotensin_II in cardiac fibroblasts .
14760941	1	oxygen	103,109	IL-6	85,89	oxygen	IL-6	MESH:D010100	16193(Tax:10090)	Chemical	Gene	intermediates|compound|START_ENTITY intermediates|amod|END_ENTITY	Differential regulation of IL-6 and reactive oxygen intermediates -LRB- ROIs -RRB- synthesis as a possible homeostatic mechanism in the control of inflammation .
19164521	0	oxygen	55,61	Indy	11,15	oxygen	Indy	MESH:D010100	40049(Tax:7227)	Chemical	Gene	production|compound|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Long-lived Indy induces reduced mitochondrial reactive oxygen species production and oxidative damage .
9022680	0	oxygen	114,120	Interleukin-1_beta	0,18	oxygen	Interleukin-1 beta	MESH:D010100	3553	Chemical	Gene	intermediates|compound|START_ENTITY production|nmod|intermediates cells|nmod|production induces|nmod|cells induces|nsubj|END_ENTITY	Interleukin-1_beta induces nuclear factor kappa B in epithelial cells independently of the production of reactive oxygen intermediates .
9513043	0	oxygen	116,122	Interleukin-1_beta	0,18	oxygen	Interleukin-1 beta	MESH:D010100	281251(Tax:9913)	Chemical	Gene	species|compound|START_ENTITY involvement|nmod|species induction|dep|involvement induction|amod|END_ENTITY	Interleukin-1_beta induction of c-fos and collagenase expression in articular chondrocytes : involvement of reactive oxygen species .
9790925	0	oxygen	32,38	Interleukin-1_beta	0,18	oxygen	Interleukin-1 beta	MESH:D010100	3553	Chemical	Gene	species|compound|START_ENTITY species|amod|END_ENTITY	Interleukin-1_beta and reactive oxygen species mediate activation of c-Jun NH2-terminal kinases , in human epithelial cells , by two independent pathways .
10947166	0	oxygen	29,35	Interleukin-1beta	0,17	oxygen	Interleukin-1beta	MESH:D010100	100008990(Tax:9986)	Chemical	Gene	relationship|compound|START_ENTITY alters|dobj|relationship alters|nsubj|END_ENTITY	Interleukin-1beta alters the oxygen delivery-oxygen consumption relationship in rabbits by increasing the slope of the supply-independent line .
21863240	0	oxygen	50,56	Itch	33,37	oxygen	Itch	MESH:D010100	83737	Chemical	Gene	species|compound|START_ENTITY END_ENTITY|nmod|species	Impact of JNK1 , JNK2 , and ligase Itch on reactive oxygen species formation and survival of prostate_cancer cells treated with diallyl_trisulfide .
10103024	0	oxygen	122,128	JNK	40,43	oxygen	JNK	MESH:D010100	5599	Chemical	Gene	induced|nmod|START_ENTITY pattern|acl|induced activation|dobj|pattern activation|nsubj|kinase kinase|dep|p38 p38|dep|END_ENTITY	Mitogen-activated protein kinase -LRB- p38 - , JNK - , ERK - -RRB- activation pattern induced by extracellular and intracellular singlet oxygen and UVA .
10766791	0	oxygen	78,84	JNK	20,23	oxygen	JNK	MESH:D010100	26419(Tax:10090)	Chemical	Gene	species|compound|START_ENTITY mediate|nmod|species mediate|dobj|activation activation|compound|END_ENTITY	Src and Cas mediate JNK activation but not ERK1/2 and p38 kinases by reactive oxygen species .
15026320	0	oxygen	9,15	JNK	120,123	oxygen	JNK	MESH:D010100	5599	Chemical	Gene	species|compound|START_ENTITY species|dep|terminal_kinase terminal_kinase|appos|END_ENTITY	Reactive oxygen species -LRB- ROS -RRB- , troublemakers between nuclear_factor-kappaB -LRB- NF-kappaB -RRB- and c-Jun_NH -LRB- 2 -RRB- - terminal_kinase -LRB- JNK -RRB- .
15545623	0	oxygen	91,97	JNK	0,3	oxygen	JNK	MESH:D010100	26419(Tax:10090)	Chemical	Gene	species|compound|START_ENTITY production|nmod|species increasing|dobj|production potentiates|advcl|increasing potentiates|nsubj|END_ENTITY	JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species .
15917192	0	oxygen	72,78	JNK	0,3	oxygen	JNK	MESH:D010100	5599	Chemical	Gene	species|compound|START_ENTITY reactive|dobj|species limits|xcomp|reactive limits|nsubj|activation activation|compound|END_ENTITY	JNK activation limits dendritic cell maturation in response to reactive oxygen species by the induction of apoptosis .
16540388	0	oxygen	76,82	JNK	0,3	oxygen	JNK	MESH:D010100	5599	Chemical	Gene	mediated|nmod|START_ENTITY death|acl|mediated modulator|nmod|death modulator|nsubj|signaling signaling|compound|END_ENTITY	JNK signaling pathway is a key modulator in cell death mediated by reactive oxygen and nitrogen species .
18336854	0	oxygen	9,15	JNK	167,170	oxygen	JNK	MESH:D010100	26419(Tax:10090)	Chemical	Gene	cleavage|compound|START_ENTITY participates|nsubj|cleavage participates|nmod|inhibition inhibition|nmod|activity activity|nmod|activation activation|compound|END_ENTITY	Reactive oxygen species-dependent HSP90 protein cleavage participates in arsenical As -LRB- +3 -RRB- - and MMA -LRB- +3 -RRB- - induced apoptosis through inhibition of telomerase activity via JNK activation .
18728404	0	oxygen	96,102	JNK	4,7	oxygen	JNK	MESH:D010100	5599	Chemical	Gene	mediated|nmod|START_ENTITY apoptosis|acl|mediated involved|nmod|apoptosis involved|nsubjpass|signaling signaling|compound|END_ENTITY	The JNK signaling pathway is involved in sodium-selenite-induced apoptosis mediated by reactive oxygen in HepG2 cells .
19849792	0	oxygen	94,100	JNK	29,32	oxygen	JNK	MESH:D010100	116554(Tax:10116)	Chemical	Gene	neuroprotection|nmod|START_ENTITY enhances|dobj|neuroprotection inhibitor|ccomp|enhances inhibitor|nsubj|kinase kinase|appos|END_ENTITY	The c-Jun N-terminal kinase -LRB- JNK -RRB- inhibitor XG-102 enhances the neuroprotection of hyperbaric oxygen after cerebral_ischaemia in adult rats .
19855432	0	oxygen	81,87	JNK	44,47	oxygen	JNK	MESH:D010100	5599	Chemical	Gene	species|compound|START_ENTITY regulation|nmod|species regulation|compound|END_ENTITY	Prevention of premature senescence requires JNK regulation of Bcl-2 and reactive oxygen species .
21038848	0	oxygen	113,119	JNK	88,91	oxygen	JNK	MESH:D010100	5599	Chemical	Gene	mediated|nmod|START_ENTITY END_ENTITY|acl|mediated	Diallyl_disulfide induces apoptosis in human leukemia HL-60 cells through activation of JNK mediated by reactive oxygen .
21454558	0	oxygen	125,131	JNK	39,42	oxygen	JNK	MESH:D010100	5599	Chemical	Gene	generation|compound|START_ENTITY amplification|nmod|generation resulting|nmod|amplification changes|acl|resulting initiates|dobj|changes initiates|nsubj|c-Jun_N-terminal_kinase c-Jun_N-terminal_kinase|appos|END_ENTITY	Mitochondrial c-Jun_N-terminal_kinase -LRB- JNK -RRB- signaling initiates physiological changes resulting in amplification of reactive oxygen species generation .
21676946	0	oxygen	42,48	JNK	67,70	oxygen	JNK	MESH:D010100	5599	Chemical	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	The SUMO E3-ligase PIAS1 couples reactive oxygen species-dependent JNK activation to oxidative cell death .
22771329	0	oxygen	9,15	JNK	47,50	oxygen	JNK	MESH:D010100	5599	Chemical	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Reactive oxygen species-mediated activation of JNK and down-regulation of DAXX are critically involved in penta-O-galloyl-beta-d-glucose-induced apoptosis in chronic_myeloid_leukemia K562 cells .
23584725	0	oxygen	117,123	JNK	155,158	oxygen	JNK	MESH:D010100	26419(Tax:10090)	Chemical	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Delphinidin prevents hypoxia-induced mouse embryonic_stem cell apoptosis through reduction of intracellular reactive oxygen species-mediated activation of JNK and NF-kB , and Akt inhibition .
24476312	0	oxygen	149,155	JNK	124,127	oxygen	JNK	MESH:D010100	5599	Chemical	Gene	species|compound|START_ENTITY mediated|nmod|species END_ENTITY|acl|mediated	ent-kaurane_diterpenoids from Croton tonkinensis induce apoptosis in colorectal_cancer cells through the phosphorylation of JNK mediated by reactive oxygen species and dual-specificity JNK kinase MKK4 .
25294812	0	oxygen	46,52	JNK	84,87	oxygen	JNK	MESH:D010100	5599	Chemical	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Ciclopirox induces autophagy through reactive oxygen species-mediated activation of JNK signaling pathway .
26343144	0	oxygen	88,94	JNK	53,56	oxygen	JNK	MESH:D010100	5599	Chemical	Gene	generation|compound|START_ENTITY mediated|nmod|generation signaling|acl|mediated signaling|compound|END_ENTITY	Cryptotanshinone induces pro-death autophagy through JNK signaling mediated by reactive oxygen species generation in lung_cancer cells .
26477638	0	oxygen	150,156	JNK	174,177	oxygen	JNK	MESH:D010100	26419(Tax:10090)	Chemical	Gene	pathways|compound|START_ENTITY pathways|compound|END_ENTITY	Protective effects of 2,3,5,4 ' - tetrahydroxystilbene-2-O-b-d-glucoside in the MPTP-induced mouse model of Parkinson 's _ disease : Involvement of reactive oxygen species-mediated JNK , P38 and mitochondrial pathways .
26517353	0	oxygen	34,40	JNK	74,77	oxygen	JNK	MESH:D010100	5599	Chemical	Gene	results|compound|START_ENTITY results|nmod|activation activation|nmod|cascade cascade|compound|END_ENTITY	Fusarochromanone-induced reactive oxygen species results in activation of JNK cascade and cell death by inhibiting protein phosphatases 2A and 5 .
9188778	0	oxygen	8,14	JNK	42,45	oxygen	JNK	MESH:D010100	5599	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|nmod|END_ENTITY	Singlet oxygen mediates the activation of JNK by UVA radiation in human skin fibroblasts .
16257269	0	oxygen	27,33	Janus_kinase_2	96,110	oxygen	Janus kinase 2	MESH:D010100	3717	Chemical	Gene	species|compound|START_ENTITY mediate|nsubj|species mediate|nmod|END_ENTITY	Hyperglycemia and reactive oxygen species mediate apoptosis in aortic endothelial cells through Janus_kinase_2 .
23372771	0	oxygen	50,56	Klf4	21,25	oxygen	Klf4	MESH:D010100	16600(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Transcription factor Klf4 , induced in the lung by oxygen at birth , regulates perinatal fibroblast and myofibroblast differentiation .
24145091	7	oxygen	1232,1238	MDA	1274,1277	oxygen	CAT	MESH:D010100	24248(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY species|appos|END_ENTITY	Consistently , resveratrol reduced oxalate-mediated production of reactive oxygen species -LRB- ROS -RRB- and malondialdehyde -LRB- MDA -RRB- in oxalate-treated HRCs , while the activities of anti-oxidant enzymes such as superoxide dismutase -LRB- SOD -RRB- , catalase -LRB- CAT -RRB- and glutathione peroxidase -LRB- GPx -RRB- were enhanced by resveratrol in HRCs and EG-treated kidneys of rats .
25158572	5	oxygen	810,816	MDA	863,866	oxygen	SOD	MESH:D010100	6647	Chemical	Gene	species|compound|START_ENTITY species|appos|END_ENTITY	Treatment with 50 microM simvastatin for 48 h significantly increased reactive oxygen species -LRB- ROS -RRB- production and malondialdehyde -LRB- MDA -RRB- , a lipid peroxidation production , and augmented the activity of total superoxide_dismutase -LRB- SOD -RRB- and manganese SOD -LRB- SOD2 -RRB- .
20858479	0	oxygen	45,51	MDR1	23,27	oxygen	MDR1	MESH:D010100	5243	Chemical	Gene	species|compound|START_ENTITY END_ENTITY|nmod|species	C-Phycocyanin inhibits MDR1 through reactive oxygen species and cyclooxygenase-2 mediated pathways in human hepatocellular_carcinoma cell line .
16002781	0	oxygen	102,108	MMP-2	126,131	oxygen	MMP-2	MESH:D010100	4313	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Activation of transforming_growth_factor-beta1 / p38/Smad3 signaling in stromal cells requires reactive oxygen species-mediated MMP-2 activity during bone marrow_damage .
16713603	0	oxygen	208,214	MMP-2	101,106	oxygen	MMP-2	MESH:D010100	4313	Chemical	Gene	species|compound|START_ENTITY species|compound|END_ENTITY	Salvianolic_acid_B from Salvia miltiorrhiza inhibits tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- - induced MMP-2 upregulation in human aortic smooth muscle cells via suppression of NAD -LRB- P -RRB- H oxidase-derived reactive oxygen species .
21731450	0	oxygen	9,15	MMP-2	68,73	oxygen	MMP-2	MESH:D010100	81686(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY regulates|nsubj|species regulates|dobj|expression expression|compound|END_ENTITY	Reactive oxygen species released from hypoxic hepatocytes regulates MMP-2 expression in hepatic stellate cells .
24436993	0	oxygen	22,28	MMP-2	32,37	oxygen	MMP-2	MESH:D010100	81686(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|amod|END_ENTITY	Effects of hyperbaric oxygen on MMP-2 and MMP-9 expression and spinal_cord_edema after spinal_cord_injury .
24513198	0	oxygen	22,28	MMP-2	32,37	oxygen	MMP-2	MESH:D010100	81686(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expressions expressions|amod|END_ENTITY	Effects of hyperbaric oxygen on MMP-2 and MMP-9 expressions and spinal_cord_edema after spinal_cord_injury .
12387824	0	oxygen	36,42	MMP-9	17,22	oxygen	MMP-9	MESH:D010100	17395(Tax:10090)	Chemical	Gene	species|compound|START_ENTITY END_ENTITY|nmod|species	IL-1beta induces MMP-9 via reactive oxygen species and NF-kappaB in murine macrophage RAW 264.7 cells .
19135132	0	oxygen	83,89	MMP-9	21,26	oxygen	MMP-9	MESH:D010100	4318	Chemical	Gene	model|compound|START_ENTITY expression|nmod|model inhibits|nmod|expression inhibits|dobj|expression expression|compound|END_ENTITY	Resveratrol inhibits MMP-9 expression by up-regulating PPAR_alpha expression in an oxygen glucose deprivation-exposed neuron model .
20824409	0	oxygen	11,17	MMP-9	28,33	oxygen	MMP-9	MESH:D010100	4318	Chemical	Gene	effect|compound|START_ENTITY effect|nmod|END_ENTITY	Hyperbaric oxygen effect on MMP-9 after a vascular insult .
24060804	0	oxygen	4,10	MMP-9	33,38	oxygen	MMP-9	MESH:D010100	81687(Tax:10116)	Chemical	Gene	control|nsubj|START_ENTITY control|dobj|expression expression|compound|END_ENTITY	The oxygen free radicals control MMP-9 and transcription factors expression in the spontaneously hypertensive rat .
26628974	0	oxygen	21,27	MMP9/2	31,37	oxygen	MMP9/2	MESH:D010100	81687;81686	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effect of hyperbaric oxygen on MMP9/2 expression and motor function in rats with spinal_cord_injury .
26698664	0	oxygen	55,61	MST1	93,97	oxygen	MST1	MESH:D010100	4485	Chemical	Gene	stimulation|compound|START_ENTITY stimulation|nmod|END_ENTITY	TRAF2 functions as an activator switch in the reactive oxygen species-induced stimulation of MST1 .
11919081	0	oxygen	105,111	MUC5AC	28,34	oxygen	MUC5AC	MESH:D010100	4586	Chemical	Gene	species|compound|START_ENTITY involving|dobj|species pathway|acl|involving epithelium|nmod|pathway expression|nmod|epithelium expression|compound|END_ENTITY	Neutrophil elastase induces MUC5AC gene expression in airway epithelium via a pathway involving reactive oxygen species .
20709182	0	oxygen	97,103	MUC5AC	77,83	oxygen	MUC5AC	MESH:D010100	4586	Chemical	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	Arylhydrocarbon receptor -LRB- AhR -RRB- activation in airway epithelial cells induces MUC5AC via reactive oxygen species -LRB- ROS -RRB- production .
22629429	0	oxygen	70,76	Macrophage_migration_inhibitory_factor	0,38	oxygen	Macrophage migration inhibitory factor	MESH:D010100	4282	Chemical	Gene	generation|compound|START_ENTITY autophagy|nmod|generation induces|dobj|autophagy induces|nsubj|END_ENTITY	Macrophage_migration_inhibitory_factor induces autophagy via reactive oxygen species generation .
9651187	0	oxygen	59,65	MnSOD	31,36	oxygen	MnSOD	MESH:D010100	20656(Tax:10090)	Chemical	Gene	toxicity|compound|START_ENTITY END_ENTITY|nmod|toxicity	Susceptibility of heterozygous MnSOD gene-knockout mice to oxygen toxicity .
22322369	0	oxygen	75,81	Myeloperoxidase	0,15	oxygen	Myeloperoxidase	MESH:D010100	17523(Tax:10090)	Chemical	Gene	species|compound|START_ENTITY generating|dobj|species exacerbates|advcl|generating exacerbates|nsubj|END_ENTITY	Myeloperoxidase exacerbates secondary_injury by generating highly reactive oxygen species and mediating neutrophil recruitment in experimental spinal_cord_injury .
6087808	0	oxygen	34,40	Myeloperoxidase	0,15	oxygen	Myeloperoxidase	MESH:D010100	4353	Chemical	Gene	generation|compound|START_ENTITY singlet|dobj|generation singlet|nsubj|END_ENTITY	Myeloperoxidase singlet molecular oxygen generation detected by direct infrared electronic emission .
1433311	0	oxygen	20,26	Myoglobin	0,9	oxygen	Myoglobin	MESH:D010100	59108(Tax:10116)	Chemical	Gene	consumption|compound|START_ENTITY supported|dobj|consumption supported|nsubj|END_ENTITY	Myoglobin supported oxygen consumption in isolated rat hearts under dysoxic conditions .
22465476	0	oxygen	52,58	Myoglobin	0,9	oxygen	Myoglobin	MESH:D010100	4151	Chemical	Gene	bound|nmod|START_ENTITY relationship|acl|bound END_ENTITY|dep|relationship	Myoglobin and mitochondria : a relationship bound by oxygen and nitric_oxide .
25987728	0	oxygen	10,16	Myoglobin	0,9	oxygen	Myoglobin	MESH:D010100	4151	Chemical	Gene	affinity|compound|START_ENTITY affinity|compound|END_ENTITY	Myoglobin oxygen affinity in aquatic and terrestrial birds and mammals .
25987728	0	oxygen	10,16	Myoglobin	0,9	oxygen	Myoglobin	MESH:D010100	4151	Chemical	Gene	affinity|compound|START_ENTITY affinity|compound|END_ENTITY	Myoglobin oxygen affinity in aquatic and terrestrial birds and mammals .
3791352	0	oxygen	22,28	Myoglobin	0,9	oxygen	Myoglobin	MESH:D010100	4151	Chemical	Gene	diffusion|compound|START_ENTITY maintains|nsubj|diffusion facilitated|ccomp|maintains facilitated|nsubj|END_ENTITY	Myoglobin facilitated oxygen diffusion maintains mechanical function of mammalian cardiac_muscle .
861221	0	oxygen	16,22	Myoglobin	0,9	oxygen	Myoglobin	MESH:D010100	4151	Chemical	Gene	indicator|compound|START_ENTITY END_ENTITY|nmod|indicator	Myoglobin as an oxygen indicator for measuring the oxygen binding characteristics of a modified myoglobin derivative containing covalently bound mesoheme .
861221	0	oxygen	51,57	Myoglobin	0,9	oxygen	Myoglobin	MESH:D010100	4151	Chemical	Gene	measuring|dobj|START_ENTITY indicator|acl|measuring END_ENTITY|nmod|indicator	Myoglobin as an oxygen indicator for measuring the oxygen binding characteristics of a modified myoglobin derivative containing covalently bound mesoheme .
15454861	0	oxygen	98,104	NADPH_oxidase	145,158	oxygen	NADPH oxidase	MESH:D010100	100008852(Tax:9986)	Chemical	Gene	species|compound|START_ENTITY species|dep|role role|nmod|END_ENTITY	Acetylcholine-induced relaxation of rabbit basilar artery in vitro is rapidly reduced by reactive oxygen species in acute hyperglycemia : role of NADPH_oxidase .
20018867	0	oxygen	9,15	NADPH_oxidase_1	29,44	oxygen	NADPH oxidase 1	MESH:D010100	114243(Tax:10116)	Chemical	Gene	START_ENTITY|acl|generated generated|nmod|END_ENTITY	Reactive oxygen generated by NADPH_oxidase_1 -LRB- Nox1 -RRB- contributes to cell invasion by regulating matrix metalloprotease-9 production and cell migration .
11171586	0	oxygen	9,15	NF-kappaB	84,93	oxygen	NF-kappaB	MESH:D010100	4790	Chemical	Gene	species|compound|START_ENTITY species|dep|END_ENTITY	Reactive oxygen species from NAD -LRB- P -RRB- H : quinone oxidoreductase constitutively activate NF-kappaB in malignant_melanoma cells .
12842456	0	oxygen	9,15	NF-kappaB	75,84	oxygen	NF-kappaB	MESH:D010100	4790	Chemical	Gene	species|compound|START_ENTITY mediate|nsubj|species mediate|dobj|activation activation|compound|END_ENTITY	Reactive oxygen species mediate endotoxin-induced human dermal endothelial NF-kappaB activation .
17189834	0	oxygen	9,15	NFkappaB	100,108	oxygen	NFkappaB	MESH:D010100	4790	Chemical	Gene	species|compound|START_ENTITY species|dep|role role|nmod|END_ENTITY	Reactive oxygen species in in vitro pesticide-induced neuronal cell -LRB- SH-SY5Y -RRB- cytotoxicity : role of NFkappaB and caspase-3 .
27014913	0	oxygen	23,29	NLRP3	47,52	oxygen	NLRP3	MESH:D010100	114548	Chemical	Gene	activation|nummod|START_ENTITY activation|compound|END_ENTITY	Mitochondrial reactive oxygen species-mediated NLRP3 inflammasome activation contributes to aldosterone-induced renal_tubular_cells_injury .
25661082	0	oxygen	106,112	NOX1	88,92	oxygen	NOX1	MESH:D010100	114243(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY species|compound|END_ENTITY	Sphingosylphosphorylcholine potentiates vasoreactivity and voltage-gated Ca2 + entry via NOX1 and reactive oxygen species .
20532218	0	oxygen	33,39	NOX2	15,19	oxygen	NOX2	MESH:D010100	1536	Chemical	Gene	species|compound|START_ENTITY species|compound|END_ENTITY	Requirement of NOX2 and reactive oxygen species for efficient RIG-I-mediated antiviral response through regulation of MAVS expression .
18568954	0	oxygen	50,56	NOXA1	18,23	oxygen	NOXA1	MESH:D010100	10811	Chemical	Gene	species|compound|START_ENTITY role|nmod|species role|nmod|END_ENTITY	Essential role of NOXA1 in generation of reactive oxygen species induced by oxidized low-density lipoprotein in human vascular endothelial cells .
15994299	6	oxygen	1154,1160	Nox1	1177,1181	oxygen	Nox1	MESH:D010100	27035	Chemical	Gene	generation|compound|START_ENTITY generation|nmod|END_ENTITY	Small interfering RNAs decreased endogenous p22phox expression and inhibited reactive oxygen generation from Nox1 , Nox2 , Nox3 , and Nox4 but not Nox5 .
21123734	0	oxygen	36,42	Nox4	0,4	oxygen	Nox4	MESH:D010100	50507	Chemical	Gene	species|compound|START_ENTITY species|compound|END_ENTITY	Nox4 NADPH oxidase-derived reactive oxygen species , via endogenous carbon_monoxide , promote survival of brain endothelial cells during TNF-a-induced apoptosis .
25062272	0	oxygen	37,43	Nox4	0,4	oxygen	Nox4	MESH:D010100	50507	Chemical	Gene	sensor|compound|START_ENTITY END_ENTITY|dep|sensor	Nox4 : a hydrogen_peroxide-generating oxygen sensor .
15896789	0	oxygen	125,131	Nrf2	8,12	oxygen	Nrf2	MESH:D010100	18024(Tax:10090)	Chemical	Gene	protection|nmod|START_ENTITY Role|dep|protection Role|nmod|END_ENTITY	Role of Nrf2 signaling in regulation of antioxidants and phase 2 enzymes in cardiac fibroblasts : protection against reactive oxygen and nitrogen species-induced cell injury .
16723711	0	oxygen	103,109	Nrf2	181,185	oxygen	Nrf2	MESH:D010100	18024(Tax:10090)	Chemical	Gene	species|compound|START_ENTITY inflammation|nmod|species inflammation|nmod|mice mice|acl|lacking lacking|dobj|END_ENTITY	Multiorgan autoimmune inflammation , enhanced lymphoproliferation , and impaired homeostasis of reactive oxygen species in mice lacking the antioxidant-activated transcription factor Nrf2 .
17507167	0	oxygen	17,23	Nrf2	49,53	oxygen	Nrf2	MESH:D010100	18024(Tax:10090)	Chemical	Gene	species|compound|START_ENTITY Role|nmod|species Role|nmod|ischemic_reperfusion_injury ischemic_reperfusion_injury|amod|END_ENTITY	Role of reactive oxygen species in modulation of Nrf2 following ischemic_reperfusion_injury .
18372916	0	oxygen	39,45	Nrf2	12,16	oxygen	Nrf2	MESH:D010100	4780	Chemical	Gene	species|compound|START_ENTITY END_ENTITY|nmod|species	The role of Nrf2 in increased reactive oxygen species and DNA damage in prostate tumorigenesis .
19129213	0	oxygen	174,180	Nrf2	10,14	oxygen	Nrf2	MESH:D010100	18024(Tax:10090)	Chemical	Gene	species|compound|START_ENTITY reactive|dobj|species those|acl:relcl|reactive increases|nmod|those increases|nsubj|activation activation|amod|END_ENTITY	Increased Nrf2 activation in livers from Keap1-knockdown mice increases expression of cytoprotective genes that detoxify electrophiles more than those that detoxify reactive oxygen species .
19778293	0	oxygen	84,90	Nrf2	37,41	oxygen	Nrf2	MESH:D010100	18024(Tax:10090)	Chemical	Gene	species|compound|START_ENTITY regulates|nmod|species regulates|dobj|activation activation|amod|END_ENTITY	Extracellular redox status regulates Nrf2 activation through mitochondrial reactive oxygen species .
19797052	0	oxygen	125,131	Nrf2	29,33	oxygen	Nrf2	MESH:D010100	4780	Chemical	Gene	species|compound|START_ENTITY role|nmod|species keep|parataxis|role contributes|xcomp|keep contributes|nsubj|NF-E2-related_factor NF-E2-related_factor|appos|END_ENTITY	Active NF-E2-related_factor -LRB- Nrf2 -RRB- contributes to keep endothelial NO synthase -LRB- eNOS -RRB- in the coupled state : role of reactive oxygen species -LRB- ROS -RRB- , eNOS , and heme oxygenase -LRB- HO-1 -RRB- levels .
20417615	0	oxygen	28,34	Nrf2	52,56	oxygen	Nrf2	MESH:D010100	18024(Tax:10090)	Chemical	Gene	level|compound|START_ENTITY lowers|dobj|level lowers|nmod|activation activation|amod|END_ENTITY	Simvastatin lowers reactive oxygen species level by Nrf2 activation via PI3K/Akt pathway .
23404377	0	oxygen	9,15	Nrf2	98,102	oxygen	Nrf2	MESH:D010100	4780	Chemical	Gene	species|compound|START_ENTITY regulate|nsubj|species regulate|dobj|expression expression|nmod|vascular_endothelial_growth_factor vascular_endothelial_growth_factor|nmod|END_ENTITY	Reactive oxygen species regulate FSH-induced expression of vascular_endothelial_growth_factor via Nrf2 and HIF1a signaling in human epithelial_ovarian_cancer .
24191235	0	oxygen	122,128	Nrf2	0,4	oxygen	Nrf2	MESH:D010100	4780	Chemical	Gene	roles|nmod|START_ENTITY hypoxia|dep|roles supports|nmod|hypoxia supports|nsubj|activation activation|amod|END_ENTITY	Nrf2 activation supports cell survival during hypoxia and hypoxia/reoxygenation in cardiomyoblasts ; the roles of reactive oxygen and nitrogen species .
24716787	0	oxygen	98,104	Nrf2	0,4	oxygen	Nrf2	MESH:D010100	18024(Tax:10090)	Chemical	Gene	preconditioning|compound|START_ENTITY induced|nmod|preconditioning tolerance|acl|induced contributes|nmod|tolerance contributes|nsubj|activation activation|amod|END_ENTITY	Nrf2 activation in astrocytes contributes to spinal cord ischemic tolerance induced by hyperbaric oxygen preconditioning .
24924401	0	oxygen	80,86	Nrf2	8,12	oxygen	Nrf2	MESH:D010100	18024(Tax:10090)	Chemical	Gene	alters|dobj|START_ENTITY congenital_intrahepatic_shunt|acl:relcl|alters evokes|dobj|congenital_intrahepatic_shunt evokes|nsubj|Loss Loss|nmod|END_ENTITY	Loss of Nrf2 in mice evokes a congenital_intrahepatic_shunt that alters hepatic oxygen and protein expression gradients and toxicity .
26729624	0	oxygen	11,17	Nrf2	90,94	oxygen	Nrf2	MESH:D010100	83619(Tax:10116)	Chemical	Gene	preconditioning|compound|START_ENTITY ameliorates|nsubj|preconditioning ameliorates|xcomp|hypoxia-ischemia_brain_damage hypoxia-ischemia_brain_damage|advcl|activating activating|dobj|expression expression|amod|END_ENTITY	Hyperbaric oxygen preconditioning ameliorates hypoxia-ischemia_brain_damage by activating Nrf2 expression in vivo and in vitro .
16133879	0	oxygen	99,105	Ornithine_decarboxylase	0,23	oxygen	Ornithine decarboxylase	MESH:D010100	4953	Chemical	Gene	production|compound|START_ENTITY reducing|dobj|production prevents|advcl|reducing prevents|nsubj|END_ENTITY	Ornithine_decarboxylase prevents methotrexate-induced apoptosis by reducing intracellular reactive oxygen species production .
11279018	0	oxygen	109,115	P-glycoprotein	29,43	oxygen	P-glycoprotein	MESH:D010100	5243	Chemical	Gene	species|compound|START_ENTITY spheroids|nmod|species spheroids|nsubj|Down-regulation Down-regulation|nmod|expression expression|amod|END_ENTITY	Down-regulation of intrinsic P-glycoprotein expression in multicellular prostate_tumor spheroids by reactive oxygen species .
15389514	0	oxygen	137,143	P-glycoprotein	51,65	oxygen	P-glycoprotein	MESH:D010100	5243	Chemical	Gene	species|compound|START_ENTITY spheroids|nmod|species spheroids|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of the multidrug resistance transporter P-glycoprotein in multicellular prostate_tumor spheroids by hyperthermia and reactive oxygen species .
16083877	0	oxygen	9,15	P-glycoprotein	82,96	oxygen	P-glycoprotein	MESH:D010100	5243	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Reactive oxygen species-linked regulation of the multidrug resistance transporter P-glycoprotein in Nox-1 overexpressing prostate_tumor spheroids .
26169035	0	oxygen	177,183	P-glycoprotein	55,69	oxygen	P-glycoprotein	MESH:D010100	5243	Chemical	Gene	species|compound|START_ENTITY regulated|nmod|species regulated|dobj|expression expression|amod|END_ENTITY	BME , a novel compound of anthraquinone , down regulated P-glycoprotein expression in doxorubicin-resistant human myelogenous_leukemia -LRB- K562/DOX -RRB- cells via generation of reactive oxygen species .
11441983	0	oxygen	8,14	P-selectin	40,50	oxygen	P-selectin	MESH:D010100	6403	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Singlet oxygen inhibits agonist-induced P-selectin expression and formation of platelet aggregates .
12384485	0	oxygen	69,75	P-selectin	34,44	oxygen	P-selectin	MESH:D010100	6403	Chemical	Gene	generation|compound|START_ENTITY upregulation|nmod|generation upregulation|nmod|expression expression|amod|END_ENTITY	Rapid upregulation of endothelial P-selectin expression via reactive oxygen species generation .
22142906	0	oxygen	56,62	P-selectin	106,116	oxygen	P-selectin	MESH:D010100	6403	Chemical	Gene	species|compound|START_ENTITY production|nmod|species production|nmod|END_ENTITY	C1q regulates collagen-dependent production of reactive oxygen species , aggregation and levels of soluble P-selectin in whole blood .
9127326	0	oxygen	20,26	P-selectin	126,136	oxygen	P-selectin	MESH:D010100	6403	Chemical	Gene	production|compound|START_ENTITY production|dep|role role|nmod|adhesion adhesion|nmod|neutrophils neutrophils|nmod|END_ENTITY	Neutrophil reactive oxygen species production during hemodialysis : role of activated platelet adhesion to neutrophils through P-selectin .
10198538	0	oxygen	72,78	P50	38,41	oxygen	P50	MESH:D010100	4790	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|nmod|transport	Engineered erythrocytes : influence of P50 rightward shift and oxemia on oxygen transport to tissues .
1148470	0	oxygen	27,33	P50	60,63	oxygen	P50	MESH:D010100	4790	Chemical	Gene	analysis|nmod|START_ENTITY release|nsubj|analysis release|xcomp|due due|nmod|changes changes|nmod|END_ENTITY	A quantitative analysis of oxygen release due to changes in P50 and venous PO2 .
1690029	0	oxygen	11,17	P50	32,35	oxygen	P50	MESH:D010100	4790	Chemical	Gene	dissociation|compound|START_ENTITY dissociation|appos|END_ENTITY	Hemoglobin oxygen dissociation -LRB- P50 -RRB- in bronchopulmonary_dysplasia .
2579663	0	oxygen	16,22	P50	62,65	oxygen	P50	MESH:D010100	4790	Chemical	Gene	affinity|compound|START_ENTITY affinity|nmod|newborns newborns|amod|END_ENTITY	The whole blood oxygen affinity in normal human newborns : II -RRB- P50 , n value and related parameters .
2706089	0	oxygen	36,42	P50	44,47	oxygen	P50	MESH:D010100	4790	Chemical	Gene	pressure|nmod|START_ENTITY Modification|nmod|pressure Modification|appos|END_ENTITY	Modification of partial pressure of oxygen -LRB- P50 -RRB- in mammalian red blood cells by incorporation of an allosteric effector of hemoglobin .
3140916	0	oxygen	34,40	P50	62,65	oxygen	P50	MESH:D010100	4790	Chemical	Gene	transport|compound|START_ENTITY variables|nmod|transport variables|nmod|END_ENTITY	Optimal hematologic variables for oxygen transport , including P50 , hemoglobin cooperativity , hematocrit , acid-base status , and cardiac function .
3142969	0	oxygen	51,57	P50	25,28	oxygen	P50	MESH:D010100	4790	Chemical	Gene	tension|compound|START_ENTITY Effect|nmod|tension Effect|nmod|END_ENTITY	Effect of sevoflurane on P50 and on measurement of oxygen tension .
3916400	0	oxygen	50,56	P50	43,46	oxygen	P50	MESH:D010100	4790	Chemical	Gene	transport|compound|START_ENTITY Clarification|nmod|transport Clarification|nmod|effects effects|nmod|changes changes|nmod|END_ENTITY	Clarification of the effects of changes in P50 on oxygen transport .
6674658	0	oxygen	48,54	P50	142,145	oxygen	P50	MESH:D010100	4790	Chemical	Gene	curve|compound|START_ENTITY method|nmod|curve method|nmod|procedure procedure|nmod|END_ENTITY	A simple microtonometric method for whole blood oxygen dissociation curve and a critical evaluation of the `` single point '' procedure for blood P50 .
19837064	0	oxygen	23,29	PEDF	0,4	oxygen	PEDF	MESH:D010100	281386(Tax:9913)	Chemical	Gene	generation|compound|START_ENTITY prevents|dobj|generation prevents|nsubj|END_ENTITY	PEDF prevents reactive oxygen species generation and retinal endothelial cell damage at high glucose levels .
23618552	0	oxygen	77,83	PGC-1a	0,6	oxygen	PGC-1a	MESH:D010100	83516(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY reducing|dobj|production prevents|advcl|reducing prevents|nsubj|END_ENTITY	PGC-1a prevents apoptosis in adipose-derived stem cells by reducing reactive oxygen species production in a diabetic microenvironment .
24371810	0	oxygen	20,26	PGC-1a	0,6	oxygen	PGC-1a	MESH:D010100	10891	Chemical	Gene	species|compound|START_ENTITY species|amod|END_ENTITY	PGC-1a and reactive oxygen species regulate human embryonic stem cell-derived cardiomyocyte function .
26498856	0	oxygen	9,15	PHD2	4,8	oxygen	PHD2	MESH:D010100	54583	Chemical	Gene	sensor|compound|START_ENTITY sensor|compound|END_ENTITY	The PHD2 oxygen sensor paves the way to metastasis .
17684156	0	oxygen	57,63	PHD3	52,56	oxygen	PHD3	MESH:D010100	112399	Chemical	Gene	sensor|compound|START_ENTITY sensor|compound|END_ENTITY	Oxygen-dependent ATF-4 stability is mediated by the PHD3 oxygen sensor .
15203192	0	oxygen	9,15	PKB	75,78	oxygen	PKB	MESH:D010100	2185	Chemical	Gene	species|compound|START_ENTITY mediate|nsubj|species mediate|dobj|activation activation|nmod|END_ENTITY	Reactive oxygen species mediate Endothelin-1-induced activation of ERK1/2 , PKB , and Pyk2 signaling , as well as protein synthesis , in vascular smooth muscle cells .
15840586	0	oxygen	53,59	PKC-beta	95,103	oxygen	PKC-beta	MESH:D010100	18751(Tax:10090)	Chemical	Gene	species|compound|START_ENTITY species|appos|END_ENTITY	Role of p90_ribosomal_S6_kinase -LRB- p90RSK -RRB- in reactive oxygen species and protein_kinase_C_beta -LRB- PKC-beta -RRB- - mediated cardiac_troponin_I phosphorylation .
3141579	0	oxygen	56,62	PSK	0,3	oxygen	PSK	MESH:D010100	381921(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY enhances|dobj|metabolism enhances|nsubj|END_ENTITY	PSK , a polysaccharide from Coriolus vesicolor , enhances oxygen metabolism of murine peritoneal macrophages and the host resistance to listerial infection .
22634053	0	oxygen	39,45	Paraoxonase_2	0,13	oxygen	Paraoxonase 2	MESH:D010100	5445	Chemical	Gene	production|compound|START_ENTITY decreases|dobj|production decreases|nsubj|END_ENTITY	Paraoxonase_2 decreases renal reactive oxygen species production , lowers blood pressure , and mediates dopamine_D2_receptor-induced inhibition of NADPH oxidase .
21800522	0	oxygen	11,17	Part_1	41,47	oxygen	Part 1	MESH:D010100	25859	Chemical	Gene	therapy|compound|START_ENTITY therapy|dep|END_ENTITY	Delivering oxygen therapy in acute care : Part_1 .
2849792	1	oxygen	212,218	Pcj	220,223	oxygen	CO2	MESH:D010100	717	Chemical	Gene	sensors|compound|START_ENTITY sensors|appos|END_ENTITY	In order to evaluate potential applications of non-invasive fiberoptic conjunctival carbon_dioxide -LRB- Pcj , CO2 -RRB- and polarographic oxygen -LRB- Pcj , O2 -RRB- sensors , we studied the effects of graded hyper - _ and_hypoventilation on Pcj , CO2 and Pcj , O2 values in dogs .
16099207	0	oxygen	90,96	Phospholipase_D	0,15	oxygen	Phospholipase D	MESH:D010100	2822	Chemical	Gene	species|compound|START_ENTITY END_ENTITY|nmod|species	Phospholipase_D in the signaling networks of plant response to abscisic_acid and reactive oxygen species .
23662182	0	oxygen	44,50	Phospholipase_D	0,15	oxygen	Phospholipase D	MESH:D010100	2822	Chemical	Gene	lung_endothelial_barrier_dysfunction|compound|START_ENTITY mediates|dobj|lung_endothelial_barrier_dysfunction mediates|nsubj|signaling signaling|compound|END_ENTITY	Phospholipase_D signaling mediates reactive oxygen species-induced lung_endothelial_barrier_dysfunction .
9199889	0	oxygen	71,77	Phospholipase_D	0,15	oxygen	Phospholipase D	MESH:D010100	2822	Chemical	Gene	radicals|compound|START_ENTITY activation|nmod|radicals activity|dep|activation activity|amod|END_ENTITY	Phospholipase_D activity in the intestinal mitochondria : activation by oxygen free radicals .
24204775	0	oxygen	102,108	Protein_tyrosine_phosphatase_1B	0,31	oxygen	Protein tyrosine phosphatase 1B	MESH:D010100	19246(Tax:10090)	Chemical	Gene	axis|compound|START_ENTITY role|nmod|axis resistance|dep|role resistance|compound|END_ENTITY	Protein_tyrosine_phosphatase_1B and insulin resistance : role of endoplasmic reticulum stress/reactive oxygen species/nuclear factor kappa B axis .
11229364	0	oxygen	141,147	Prx-IV	81,87	oxygen	Prx-IV	MESH:D010100	53381(Tax:10090)	Chemical	Gene	species|compound|START_ENTITY END_ENTITY|nmod|species	Characterization of human and mouse peroxiredoxin_IV : evidence for inhibition by Prx-IV of epidermal_growth_factor - and p53-induced reactive oxygen species .
15259009	0	oxygen	9,15	PrxII	69,74	oxygen	PrxII	MESH:D010100	21672(Tax:10090)	Chemical	Gene	species|compound|START_ENTITY species|appos|END_ENTITY	Reactive oxygen species induced by the deletion of peroxiredoxin_II -LRB- PrxII -RRB- increases the number of thymocytes resulting in the enlargement of PrxII-null thymus .
16462764	0	oxygen	61,67	RAC-1	42,47	oxygen	RAC-1	MESH:D010100	19353(Tax:10090)	Chemical	Gene	species|compound|START_ENTITY species|amod|END_ENTITY	Pro-metastatic signaling by c-Met through RAC-1 and reactive oxygen species -LRB- ROS -RRB- .
17604276	0	oxygen	79,85	RAC-1	64,69	oxygen	RAC-1	MESH:D010100	5879	Chemical	Gene	production|compound|START_ENTITY reactive|dobj|production proliferation|dep|reactive proliferation|acl:relcl|requires requires|xcomp|END_ENTITY	Oxidative stress-mediated mesangial cell proliferation requires RAC-1 / reactive oxygen species production and beta4 integrin expression .
18070887	0	oxygen	175,181	Rac-1	64,69	oxygen	Rac-1	MESH:D010100	5879	Chemical	Gene	species|compound|START_ENTITY production|nmod|species critical|nmod|production critical|nsubj|recruitment recruitment|nmod|END_ENTITY	Phosphatidylinositol_3-kinase-dependent membrane recruitment of Rac-1 and p47phox is critical for alpha-platelet-derived growth factor receptor-induced production of reactive oxygen species .
19684199	0	oxygen	23,29	Rac1	41,45	oxygen	Rac1	MESH:D010100	19353(Tax:10090)	Chemical	Gene	species|compound|START_ENTITY species|nmod|END_ENTITY	Modulation of reactive oxygen species by Rac1 or catalase prevents asbestos-induced pulmonary_fibrosis .
16001073	0	oxygen	19,25	Rac1b	0,5	oxygen	Rac1b	MESH:D010100	170758(Tax:10090)	Chemical	Gene	species|compound|START_ENTITY species|amod|END_ENTITY	Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability .
21439370	0	oxygen	9,15	RhoA	34,38	oxygen	RhoA	MESH:D010100	11848(Tax:10090)	Chemical	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Reactive oxygen species-dependent RhoA activation mediates collagen synthesis in hyperoxic_lung_fibrosis .
21918362	0	oxygen	35,41	SHP-2	58,63	oxygen	SHP-2	MESH:D010100	5781	Chemical	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Caveolin-1 is involved in reactive oxygen species-induced SHP-2 activation in astrocytes .
21527745	0	oxygen	36,42	SUMO1	0,5	oxygen	SUMO1	MESH:D010100	7341	Chemical	Gene	production|compound|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	SUMO1 negatively regulates reactive oxygen species production from NADPH oxidases .
26234616	0	oxygen	9,15	Sea	39,42	oxygen	Sea	MESH:D010100	6395	Chemical	Gene	depletion|compound|START_ENTITY depletion|nmod|END_ENTITY	Seasonal oxygen depletion in the North Sea , a review .
24074935	0	oxygen	57,63	Selenoprotein_P	0,15	oxygen	Selenoprotein P	MESH:D010100	6414	Chemical	Gene	accumulation|compound|START_ENTITY inhibits|dobj|accumulation inhibits|nsubj|END_ENTITY	Selenoprotein_P inhibits radiation-induced late reactive oxygen species accumulation and normal cell injury .
11811528	0	oxygen	27,33	Sen	59,62	oxygen	Sen	MESH:D010100	10934	Chemical	Gene	START_ENTITY|dep|- -|compound|END_ENTITY	Photogeneration of singlet oxygen -LRB- 1O2 -RRB- and free radicals -LRB- Sen * - , O2 * - -RRB- by tetra-brominated hypocrellin_B derivative .
11796207	0	oxygen	56,62	Sod2	36,40	oxygen	Sod2	MESH:D010100	20656(Tax:10090)	Chemical	Gene	toxicity|compound|START_ENTITY END_ENTITY|nmod|toxicity	Increased sensitivity of homozygous Sod2 mutant mice to oxygen toxicity .
23626778	0	oxygen	72,78	Sp1	111,114	oxygen	Sp1	MESH:D010100	6667	Chemical	Gene	species|compound|START_ENTITY species|nmod|END_ENTITY	Insulin regulates hypoxia-inducible factor-1a transcription by reactive oxygen species sensitive activation of Sp1 in 3T3-L1 preadipocyte .
2843167	0	oxygen	125,131	Superoxide_dismutase	0,20	oxygen	Superoxide dismutase	MESH:D010100	6647	Chemical	Gene	3-hydroxyanthranilic_acid|nmod|START_ENTITY reaction|nmod|3-hydroxyanthranilic_acid radicals|nmod|reaction formation|nmod|radicals enhances|dobj|formation enhances|nsubj|END_ENTITY	Superoxide_dismutase enhances the formation of hydroxyl radicals in the reaction of 3-hydroxyanthranilic_acid with molecular oxygen .
21530688	0	oxygen	11,17	TASK	33,37	oxygen	TASK	MESH:D010100	29553(Tax:10116)	Chemical	Gene	sensitivity|compound|START_ENTITY sensitivity|nmod|END_ENTITY	Changes in oxygen sensitivity of TASK in carotid body glomus cells during early postnatal development .
21172400	0	oxygen	107,113	TGF-b	146,151	oxygen	TGF-b	MESH:D010100	59086(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY species|appos|production production|appos|TNF-a TNF-a|dep|END_ENTITY	Betulin and betulinic_acid attenuate ethanol-induced liver stellate cell activation by inhibiting reactive oxygen species -LRB- ROS -RRB- , cytokine -LRB- TNF-a , TGF-b -RRB- production and by influencing intracellular signaling .
23554457	0	oxygen	30,36	TGF-b	0,5	oxygen	TGF-b	MESH:D010100	7040	Chemical	Gene	species|compound|START_ENTITY species|nummod|END_ENTITY	TGF-b signalling and reactive oxygen species drive fibrosis and matrix remodelling in myxomatous mitral valves .
24487063	0	oxygen	116,122	TGF-b	190,195	oxygen	TGF-b	MESH:D010100	7040	Chemical	Gene	species|compound|START_ENTITY species|acl|resulting resulting|nmod|END_ENTITY	The anti-fibrotic effects of CCN1/CYR61 in primary portal myofibroblasts are mediated through induction of reactive oxygen species resulting in cellular senescence , apoptosis and attenuated TGF-b signaling .
26496488	0	oxygen	44,50	TGF-b	25,30	oxygen	TGF-b	MESH:D010100	7040	Chemical	Gene	species|compound|START_ENTITY species|amod|END_ENTITY	Reciprocal regulation of TGF-b and reactive oxygen species : A perverse cycle for fibrosis .
26825874	0	oxygen	63,69	TGF-b	38,43	oxygen	TGF-b	MESH:D010100	21803(Tax:10090)	Chemical	Gene	species|compound|START_ENTITY requires|dobj|species requires|nsubj|Transforming_growth_factor_type_beta Transforming_growth_factor_type_beta|appos|END_ENTITY	Transforming_growth_factor_type_beta -LRB- TGF-b -RRB- requires reactive oxygen species to induce skeletal muscle_atrophy .
22551312	0	oxygen	43,49	TGF-b1	23,29	oxygen	TGF-b1	MESH:D010100	59086(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY production|amod|END_ENTITY	Ethanol -LRB- EtOH -RRB- - induced TGF-b1 and reactive oxygen species production are necessary for EtOH-induced alveolar_macrophage dysfunction and induction of alternative activation .
11920680	0	oxygen	4,10	TGF-beta1	96,105	oxygen	TGF-beta1	MESH:D010100	7040	Chemical	Gene	tension|compound|START_ENTITY stimulates|nsubj|tension stimulates|nmod|action action|nmod|END_ENTITY	Low oxygen tension stimulates collagen synthesis and COL1A1 transcription through the action of TGF-beta1 .
15122306	0	oxygen	26,32	TGF-beta1	50,59	oxygen	TGF-beta1	MESH:D010100	7040	Chemical	Gene	species|compound|START_ENTITY activate|nsubj|species activate|xcomp|END_ENTITY	Asbestos-derived reactive oxygen species activate TGF-beta1 .
15770925	0	oxygen	109,115	TGF-beta1	45,54	oxygen	TGF-beta1	MESH:D010100	7040	Chemical	Gene	species|compound|START_ENTITY mediates|nmod|species mediates|dobj|END_ENTITY	Angiotensin_II mediates high glucose-induced TGF-beta1 and fibronectin upregulation in HPMC through reactive oxygen species .
15821013	0	oxygen	110,116	TGF-beta1	87,96	oxygen	TGF-beta1	MESH:D010100	443417(Tax:9940)	Chemical	Gene	species|compound|START_ENTITY species|amod|END_ENTITY	Cyclic stretch increases VEGF expression in pulmonary arterial smooth muscle cells via TGF-beta1 and reactive oxygen species : a requirement for NAD -LRB- P -RRB- H oxidase .
19631014	0	oxygen	49,55	TLR2	19,23	oxygen	TLR2	MESH:D010100	7097	Chemical	Gene	species|compound|START_ENTITY END_ENTITY|nmod|species	The involvement of TLR2 in cytokine and reactive oxygen species -LRB- ROS -RRB- production by PBMCs in response to Leishmania_major phosphoglycans -LRB- PGs -RRB- .
26709456	0	oxygen	9,15	TLR2	69,73	oxygen	TLR2	MESH:D010100	7097	Chemical	Gene	production|compound|START_ENTITY involves|nsubj|production involves|xcomp|END_ENTITY	Reactive oxygen species production by human dendritic cells involves TLR2 and dectin-1 and is essential for efficient immune response against Mycobacteria .
10532402	0	oxygen	24,30	TNF-alpha	42,51	oxygen	TNF-alpha	MESH:D010100	403922(Tax:9615)	Chemical	Gene	species|compound|START_ENTITY species|nmod|END_ENTITY	Involvement of reactive oxygen species in TNF-alpha mediated activation of the transcription factor NF-kappaB in canine dermal fibroblasts .
11159050	0	oxygen	77,83	TNF-alpha	26,35	oxygen	TNF-alpha	MESH:D010100	7124	Chemical	Gene	species|compound|START_ENTITY role|nmod|species induction|dep|role induction|nmod|END_ENTITY	Differential induction of TNF-alpha and MnSOD by endotoxin : role of reactive oxygen species and NADPH oxidase .
11420928	0	oxygen	106,112	TNF-alpha	0,9	oxygen	TNF-alpha	MESH:D010100	7124	Chemical	Gene	species|compound|START_ENTITY mediated|nmod|species mediated|nsubjpass|activation activation|amod|END_ENTITY	TNF-alpha dependent NF-kappa_B activation in cultured canine keratinocytes is partly mediated by reactive oxygen species .
11481030	2	oxygen	396,402	TNF-alpha	498,507	oxygen	TNF-alpha	MESH:D010100	21926(Tax:10090)	Chemical	Gene	participate|nsubj|START_ENTITY participate|advcl|regulating regulating|nmod|END_ENTITY	It has been suggested that both reactive oxygen and nitrogen metabolites participate in regulating adhesion molecule expression in response to TNF-alpha .
12126639	0	oxygen	9,15	TNF-alpha	70,79	oxygen	TNF-alpha	MESH:D010100	7124	Chemical	Gene	species|compound|START_ENTITY induce|nsubj|species induce|nmod|END_ENTITY	Reactive oxygen species induce cardiomyocyte apoptosis partly through TNF-alpha .
12230306	0	oxygen	136,142	TNF-alpha	24,33	oxygen	TNF-alpha	MESH:D010100	21926(Tax:10090)	Chemical	Gene	intermediates|compound|START_ENTITY role|nmod|intermediates expression|dep|role expression|amod|END_ENTITY	Methamphetamine-induced TNF-alpha gene expression and activation of AP-1 in discrete regions of mouse brain : potential role of reactive oxygen intermediates and lipid peroxidation .
12560208	0	oxygen	21,27	TNF-alpha	43,52	oxygen	TNF-alpha	MESH:D010100	24835(Tax:10116)	Chemical	Gene	consumption|compound|START_ENTITY consumption|nmod|END_ENTITY	Increased myocardial oxygen consumption by TNF-alpha is mediated by a sphingosine signaling pathway .
12817295	0	oxygen	10,16	TNF-alpha	104,113	oxygen	TNF-alpha	MESH:D010100	7124	Chemical	Gene	species|compound|START_ENTITY mediated|nsubj|species mediated|dobj|cardioprotection cardioprotection|acl|induced induced|nmod|END_ENTITY	-LSB- Reactive oxygen species and mitochondrial KATP-sensitive channels mediated cardioprotection induced by TNF-alpha during hypoxia and reoxygenation -RSB- .
15985531	0	oxygen	9,15	TNF-alpha	34,43	oxygen	TNF-alpha	MESH:D010100	7124	Chemical	Gene	species-dependent|compound|START_ENTITY END_ENTITY|nsubj|species-dependent	Reactive oxygen species-dependent TNF-alpha converting enzyme activation through stimulation of 5-HT2B and alpha1D autoreceptors in neuronal cells .
16713603	0	oxygen	208,214	TNF-alpha	82,91	oxygen	TNF-alpha	MESH:D010100	7124	Chemical	Gene	species|compound|START_ENTITY tumor_necrosis_factor-alpha|dep|species tumor_necrosis_factor-alpha|appos|END_ENTITY	Salvianolic_acid_B from Salvia miltiorrhiza inhibits tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- - induced MMP-2 upregulation in human aortic smooth muscle cells via suppression of NAD -LRB- P -RRB- H oxidase-derived reactive oxygen species .
16736108	0	oxygen	65,71	TNF-alpha	0,9	oxygen	TNF-alpha	MESH:D010100	7124	Chemical	Gene	generation|compound|START_ENTITY leukocyte|dobj|generation leukocyte|nsubj|effect effect|amod|END_ENTITY	TNF-alpha priming effect on polymorphonuclear leukocyte reactive oxygen species generation and adhesion molecule expression in hemodialyzed patients .
21166155	0	oxygen	18,24	TNF-alpha	84,93	oxygen	TNF-alpha	MESH:D010100	24835(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY species|appos|channels channels|nmod|cardioprotection cardioprotection|amod|END_ENTITY	-LSB- Role of reactive oxygen species , nitric_oxide and mitochondrial K -LRB- ATP -RRB- channels in TNF-alpha induced cardioprotection -RSB- .
8081209	0	oxygen	20,26	TNF-alpha	0,9	oxygen	TNF-alpha	MESH:D010100	24835(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|amod|END_ENTITY	TNF-alpha effect on oxygen free radical scavenging and generating enzymes in rat liver .
8391810	0	oxygen	117,123	TNF-alpha	20,29	oxygen	TNF-alpha	MESH:D010100	7124	Chemical	Gene	metabolites|compound|START_ENTITY independent|nmod|metabolites independent|nsubj|potentiation potentiation|nmod|END_ENTITY	The potentiation by TNF-alpha and PMA of Fc receptor-mediated phagocytosis in neutrophils is independent of reactive oxygen metabolites produced by NADPH oxidase and of protein kinase C .
8568258	0	oxygen	9,15	TNF-alpha	47,56	oxygen	TNF-alpha	MESH:D010100	24835(Tax:10116)	Chemical	Gene	intermediates|compound|START_ENTITY intermediates|nmod|regulators regulators|nmod|production production|amod|END_ENTITY	Reactive oxygen intermediates as regulators of TNF-alpha production in rat lung inflammation induced by silica .
9990295	0	oxygen	118,124	TNF-alpha	69,78	oxygen	TNF-alpha	MESH:D010100	7124	Chemical	Gene	species|compound|START_ENTITY role|nmod|species sensitize|parataxis|role sensitize|iobj|line line|nmod|END_ENTITY	NSAIDs and butyrate sensitize a human colorectal cancer cell line to TNF-alpha and Fas ligation : the role of reactive oxygen species .
26076811	0	oxygen	87,93	TNFR1	140,145	oxygen	TNFR1	MESH:D010100	21937(Tax:10090)	Chemical	Gene	species|compound|START_ENTITY species|appos|END_ENTITY	Modulation of PKC signaling and induction of apoptosis through suppression of reactive oxygen species and tumor_necrosis_factor_receptor_1 -LRB- TNFR1 -RRB- : key role of quercetin in cancer prevention .
18301379	0	oxygen	22,28	TNFalpha	0,8	oxygen	TNFalpha	MESH:D010100	7124	Chemical	Gene	species|compound|START_ENTITY species|compound|END_ENTITY	TNFalpha and reactive oxygen species in necrotic cell death .
15987718	0	oxygen	119,125	TRAIL	77,82	oxygen	TRAIL	MESH:D010100	8743	Chemical	Gene	upregulation|compound|START_ENTITY apoptosis|nmod|upregulation necrosis|dep|apoptosis necrosis|dep|ligand ligand|appos|END_ENTITY	Curcumin sensitizes tumor necrosis factor-related apoptosis-inducing ligand -LRB- TRAIL -RRB- - induced apoptosis through reactive oxygen species-mediated upregulation of death_receptor_5 -LRB- DR5 -RRB- .
16452234	0	oxygen	157,163	TRAIL	81,86	oxygen	TRAIL	MESH:D010100	8743	Chemical	Gene	up-regulation|compound|START_ENTITY sensitizes|nmod|up-regulation sensitizes|dobj|necrosis necrosis|dep|ligand ligand|appos|END_ENTITY	Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand -LRB- TRAIL -RRB- - resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of DR5 .
19421137	0	oxygen	64,70	TRAIL	23,28	oxygen	TRAIL	MESH:D010100	8743	Chemical	Gene	species|compound|START_ENTITY modulating|dobj|species determines|advcl|modulating determines|dobj|sensitivity sensitivity|amod|END_ENTITY	TAK1 kinase determines TRAIL sensitivity by modulating reactive oxygen species and cIAP .
19438509	0	oxygen	9,15	TRAIL	116,121	oxygen	TRAIL	MESH:D010100	8743	Chemical	Gene	species|compound|START_ENTITY species|dep|mechanism mechanism|nmod|apoptosis apoptosis|nmod|treatment treatment|nmod|END_ENTITY	Reactive oxygen species up-regulate p53 and Puma ; a possible mechanism for apoptosis during combined treatment with TRAIL and wogonin .
21078664	0	oxygen	72,78	TRAIL	49,54	oxygen	TRAIL	MESH:D010100	8743	Chemical	Gene	species|compound|START_ENTITY END_ENTITY|nmod|species	Nimbolide sensitizes human colon_cancer cells to TRAIL through reactive oxygen species - and ERK-dependent up-regulation of death receptors , p53 , and Bax .
22508521	0	oxygen	43,49	TRAIL	67,72	oxygen	TRAIL	MESH:D010100	8743	Chemical	Gene	species|compound|START_ENTITY inhibition|nmod|species enhances|nsubj|inhibition enhances|dobj|sensitivity sensitivity|compound|END_ENTITY	XIAP inhibition and generation of reactive oxygen species enhances TRAIL sensitivity in inflammatory_breast_cancer cells .
22559302	0	oxygen	72,78	TRAIL	23,28	oxygen	TRAIL	MESH:D010100	8743	Chemical	Gene	species|compound|START_ENTITY Rs|dep|species Rs|nmod|END_ENTITY	The three Rs along the TRAIL : resistance , re-sensitization and reactive oxygen species -LRB- ROS -RRB- .
24612139	0	oxygen	144,150	TRAIL	96,101	oxygen	TRAIL	MESH:D010100	8743	Chemical	Gene	species|compound|START_ENTITY enhances|nmod|species enhances|dobj|effect effect|nmod|tumor_necrosis_factor-related_apoptosis-inducing_ligand tumor_necrosis_factor-related_apoptosis-inducing_ligand|appos|END_ENTITY	Quercetin enhances apoptotic effect of tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- in ovarian_cancer cells through reactive oxygen species -LRB- ROS -RRB- mediated CCAAT_enhancer-binding_protein_homologous_protein -LRB- CHOP -RRB- - death receptor 5 pathway .
25446561	0	oxygen	9,15	TRAIL	105,110	oxygen	TRAIL	MESH:D010100	8743	Chemical	Gene	species|compound|START_ENTITY contribute|nsubj|species contribute|parataxis|apoptosis apoptosis|nsubj|mechanism mechanism|nmod|induced induced|compound|END_ENTITY	Reactive oxygen species contribute to TRAIL receptors upregulation ; the mechanism for PH II-7 augmenting TRAIL induced apoptosis in leukemia cells .
25446561	0	oxygen	9,15	TRAIL	38,43	oxygen	TRAIL	MESH:D010100	8743	Chemical	Gene	species|compound|START_ENTITY contribute|nsubj|species contribute|xcomp|END_ENTITY	Reactive oxygen species contribute to TRAIL receptors upregulation ; the mechanism for PH II-7 augmenting TRAIL induced apoptosis in leukemia cells .
15904916	0	oxygen	65,71	TRF2	40,44	oxygen	TRF2	MESH:D010100	7014	Chemical	Gene	species|compound|START_ENTITY species|nummod|END_ENTITY	Up-regulation of telomere-binding TRF1 , TRF2 related to reactive oxygen species induced by As -LRB- 2 -RRB- O -LRB- 3 -RRB- in MGC-803 cells .
88	0	oxygen	4,10	Tak	35,38	oxygen	Tak	MESH:D010100	1025	Chemical	Gene	affinity|compound|START_ENTITY affinity|nmod|END_ENTITY	The oxygen affinity of haemoglobin Tak , a variant with an elongated beta chain .
15358104	0	oxygen	58,64	Thioredoxin-1	0,13	oxygen	Thioredoxin-1	MESH:D010100	22166(Tax:10090)	Chemical	Gene	species|compound|START_ENTITY mediates|nmod|species mediates|nsubj|END_ENTITY	Thioredoxin-1 mediates osteoclast stimulation by reactive oxygen species .
23329835	0	oxygen	71,77	Thioredoxin-interacting_protein	0,31	oxygen	Thioredoxin-interacting protein	MESH:D010100	56338(Tax:10090)	Chemical	Gene	generation|compound|START_ENTITY mediates|dobj|generation mediates|nsubj|END_ENTITY	Thioredoxin-interacting_protein mediates high glucose-induced reactive oxygen species generation by mitochondria and the NADPH oxidase , Nox4 , in mesangial cells .
10772365	0	oxygen	47,53	Tissue_plasminogen_activator	0,28	oxygen	Tissue plasminogen activator	MESH:D010100	100128998	Chemical	Gene	production|compound|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Tissue_plasminogen_activator inhibits reactive oxygen species production by macrophages .
27005845	0	oxygen	226,232	Toll-like_Receptor_4	43,63	oxygen	Toll-like Receptor 4	MESH:D010100	7099	Chemical	Gene	species|compound|START_ENTITY generation|nmod|species suppressing|dobj|generation inhibits|advcl|suppressing inhibits|dobj|recruitment recruitment|nmod|END_ENTITY	Soyasaponin_Bb inhibits the recruitment of Toll-like_Receptor_4 -LRB- TLR4 -RRB- into Lipid Rafts and its signaling pathway by suppressing the Nicotinamide_Adenine_Dinucleotide_Phosphate -LRB- NADPH -RRB- Oxidase-dependent generation of reactive oxygen species .
19648648	0	oxygen	144,150	Toll-like_receptor_4	21,41	oxygen	Toll-like receptor 4	MESH:D010100	7099	Chemical	Gene	manner|compound|START_ENTITY rafts|nmod|manner modulate|nmod|rafts modulate|dobj|activation activation|compound|END_ENTITY	Fatty_acids modulate Toll-like_receptor_4 activation through regulation of receptor dimerization and recruitment into lipid rafts in a reactive oxygen species-dependent manner .
25093580	0	oxygen	122,128	Toll-like_receptor_4	0,20	oxygen	Toll-like receptor 4	MESH:D010100	29260(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY contributes|nmod|production contributes|nsubj|upregulation upregulation|amod|END_ENTITY	Toll-like_receptor_4 upregulation by angiotensin_II contributes to hypertension and vascular_dysfunction through reactive oxygen species production .
10934206	0	oxygen	47,53	Tumor_necrosis_factor-alpha	0,27	oxygen	Tumor necrosis factor-alpha	MESH:D010100	7124	Chemical	Gene	species|compound|START_ENTITY generates|dobj|species generates|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha generates reactive oxygen species via a cytosolic phospholipase A2-linked cascade .
12910306	0	oxygen	128,134	Tumor_necrosis_factor-alpha	0,27	oxygen	Tumor necrosis factor-alpha	MESH:D010100	7124	Chemical	Gene	species|compound|START_ENTITY produce|dobj|species ability|acl|produce increasing|dobj|ability preactivates|advcl|increasing preactivates|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha in low doses preactivates and activates macrophages by increasing their ability to produce reactive oxygen species and oxidize low-density lipoproteins : protective effect of antioxidants .
17145855	0	oxygen	47,53	Tumor_necrosis_factor-alpha	0,27	oxygen	Tumor necrosis factor-alpha	MESH:D010100	7124	Chemical	Gene	species|compound|START_ENTITY reactive|dobj|species reactive|nsubj|increases increases|amod|END_ENTITY	Tumor_necrosis_factor-alpha increases reactive oxygen species by inducing spermine_oxidase in human lung epithelial cells : a potential mechanism for inflammation-induced carcinogenesis .
20716917	0	oxygen	86,92	Tumor_necrosis_factor-alpha	0,27	oxygen	Tumor necrosis factor-alpha	MESH:D010100	24835(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY reactive|dobj|release reactive|nsubj|control control|amod|END_ENTITY	Tumor_necrosis_factor-alpha and apoptosis_signal-regulating_kinase_1 control reactive oxygen species release , mitochondrial autophagy , and c-Jun N-terminal kinase/p38 phosphorylation during necrotizing_enterocolitis .
8097206	0	oxygen	168,174	Tumor_necrosis_factor-alpha	0,27	oxygen	Tumor necrosis factor-alpha	MESH:D010100	7124	Chemical	Gene	generation|compound|START_ENTITY inhibition|nmod|generation prevents|nmod|inhibition prevents|nsubj|blockade blockade|amod|END_ENTITY	Tumor_necrosis_factor-alpha blockade prevents neutrophil CD18 receptor upregulation and attenuates acute_lung_injury in porcine sepsis without inhibition of neutrophil oxygen radical generation .
9754325	0	oxygen	36,42	Tyrosine_hydroxylase	0,20	oxygen	Tyrosine hydroxylase	MESH:D010100	7054	Chemical	Gene	formation|compound|START_ENTITY mechanisms|nmod|formation END_ENTITY|dep|mechanisms	Tyrosine_hydroxylase : mechanisms of oxygen radical formation .
20416274	0	oxygen	44,50	UCP_1	12,17	oxygen	UCP 1	MESH:D010100	22227(Tax:10090)	Chemical	Gene	species|compound|START_ENTITY role|nmod|species role|nmod|END_ENTITY	The role of UCP_1 in production of reactive oxygen species by mitochondria isolated from brown adipose tissue .
11295118	0	oxygen	18,24	Urocortin	0,9	oxygen	Urocortin	MESH:D010100	22226(Tax:10090)	Chemical	Gene	consumption|compound|START_ENTITY reduces|dobj|consumption reduces|nsubj|END_ENTITY	Urocortin reduces oxygen consumption in lean and ob/ob mice .
10408392	0	oxygen	44,50	VEGF	130,134	oxygen	VEGF	MESH:D010100	7422	Chemical	Gene	levels|compound|START_ENTITY reduction|nmod|levels analysis|nmod|reduction required|nsubj|analysis required|xcomp|induce induce|dobj|up-regulation up-regulation|nmod|mRNA mRNA|appos|END_ENTITY	A quantitative analysis of the reduction in oxygen levels required to induce up-regulation of vascular_endothelial_growth_factor -LRB- VEGF -RRB- mRNA in cervical_cancer cell lines .
10924082	1	oxygen	82,88	VEGF	170,174	oxygen	VEGF	MESH:D010100	7422	Chemical	Gene	START_ENTITY|ccomp|stimulus stimulus|nmod|expression expression|nmod|vascular_endothelial_growth_factor vascular_endothelial_growth_factor|appos|END_ENTITY	Low oxygen -LRB- O -LRB- 2 -RRB- -RRB- is the key stimulus for expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in several adherent cells .
11095513	0	oxygen	45,51	VEGF	0,4	oxygen	VEGF	MESH:D010100	7422	Chemical	Gene	supply|compound|START_ENTITY depends|nmod|supply depends|nsubj|release release|amod|END_ENTITY	VEGF release by retinal glia depends on both oxygen and glucose supply .
11237996	0	oxygen	9,15	VEGF	34,38	oxygen	VEGF	MESH:D010100	281572(Tax:9913)	Chemical	Gene	species|compound|START_ENTITY stimulate|nsubj|species stimulate|ccomp|skeletal skeletal|nsubj|production production|amod|END_ENTITY	Reactive oxygen species stimulate VEGF production from C -LRB- 2 -RRB- C -LRB- 12 -RRB- skeletal myotubes through a PI3K/Akt pathway .
11528533	0	oxygen	90,96	VEGF	51,55	oxygen	VEGF	MESH:D010100	83785(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY mechanisms|nmod|species END_ENTITY|nmod|mechanisms	Vascular_dysfunction induced by AGE is mediated by VEGF via mechanisms involving reactive oxygen species , guanylate cyclase , and protein_kinase_C .
12037012	0	oxygen	65,71	VEGF	34,38	oxygen	VEGF	MESH:D010100	22339(Tax:10090)	Chemical	Gene	status|compound|START_ENTITY induction|nmod|status induction|nsubj|effect effect|nmod|estrogen estrogen|nmod|END_ENTITY	Contrasting effect of estrogen on VEGF induction under different oxygen status and its role in murine ROP .
12508771	0	oxygen	40,46	VEGF	0,4	oxygen	VEGF	MESH:D010100	22339(Tax:10090)	Chemical	Gene	tensions|compound|START_ENTITY associated|nmod|tensions associated|nsubjpass|release release|compound|END_ENTITY	VEGF release is associated with reduced oxygen tensions in experimental inflammatory_arthritis .
12516032	8	oxygen	1247,1253	VEGF	1212,1216	oxygen	VEGF	MESH:D010100	7422	Chemical	Gene	delivery|nmod|START_ENTITY led|nmod|delivery led|nsubj|permeability permeability|acl|resulting resulting|nmod|inhibition inhibition|nmod|END_ENTITY	The reduced vascular permeability , resulting from inhibition of VEGF , led to increased delivery of oxygen and therapeutic agents to tumors .
12573617	0	oxygen	88,94	VEGF	56,60	oxygen	VEGF	MESH:D010100	83785(Tax:10116)	Chemical	Gene	tension|compound|START_ENTITY normalizes|dobj|tension normalizes|nsubj|transfer transfer|nmod|END_ENTITY	Adeno-associated viral vector-mediated gene transfer of VEGF normalizes skeletal muscle oxygen tension and induces arteriogenesis in ischemic rat hindlimb .
12924491	0	oxygen	11,17	VEGF	88,92	oxygen	VEGF	MESH:D010100	7422	Chemical	Gene	administration|compound|START_ENTITY Effects|nmod|administration Effects|nmod|levels levels|appos|END_ENTITY	Effects of oxygen administration on the circulating vascular_endothelial_growth_factor -LRB- VEGF -RRB- levels in patients with obstructive_sleep_apnea_syndrome .
15821013	0	oxygen	110,116	VEGF	25,29	oxygen	VEGF	MESH:D010100	443103(Tax:9940)	Chemical	Gene	species|compound|START_ENTITY cells|nmod|species END_ENTITY|nmod|cells	Cyclic stretch increases VEGF expression in pulmonary arterial smooth muscle cells via TGF-beta1 and reactive oxygen species : a requirement for NAD -LRB- P -RRB- H oxidase .
16219308	0	oxygen	95,101	VEGF	31,35	oxygen	VEGF	MESH:D010100	22339(Tax:10090)	Chemical	Gene	consumption|compound|START_ENTITY independent|nmod|consumption independent|nsubj|expression expression|nmod|gene gene|amod|END_ENTITY	Cold-induced expression of the VEGF gene in brown adipose tissue is independent of thermogenic oxygen consumption .
16249273	0	oxygen	84,90	VEGF	30,34	oxygen	VEGF	MESH:D010100	7422	Chemical	Gene	species|compound|START_ENTITY production|nmod|species requires|dobj|production requires|nsubj|stimulation stimulation|nmod|translation translation|compound|END_ENTITY	Angiotensin_II stimulation of VEGF mRNA translation requires production of reactive oxygen species .
16258288	5	oxygen	1181,1187	VEGF	1048,1052	oxygen	VEGF	MESH:D010100	7422	Chemical	Gene	tension|compound|START_ENTITY expression|appos|tension responsible|nmod|expression factor|amod|responsible stabilization|nmod|factor mediated|nmod|stabilization mediated|nsubjpass|effect effect|nmod|TPO TPO|nmod|expression expression|compound|END_ENTITY	Like several other effects of the cytokine , the effect of TPO on VEGF expression is mediated by stabilization and activation of the primary transcription factor responsible for VEGF expression , the oxygen tension responsive hypoxia_inducible_factor-1 -LRB- HIF-1 -RRB- .
16328781	0	oxygen	11,17	VEGF	26,30	oxygen	VEGF	MESH:D010100	7422	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Hyperbaric oxygen induces VEGF expression through ERK , JNK and c-Jun/AP -1 activation in human umbilical vein endothelial cells .
17271453	0	oxygen	106,112	VEGF	25,29	oxygen	VEGF	MESH:D010100	443103(Tax:9940)	Chemical	Gene	species|compound|START_ENTITY cells|nmod|species END_ENTITY|nmod|cells	Cyclic stretch increases VEGF expression in pulmonary arterial smooth muscle cells via TGF-1 and reactive oxygen species : a requirement for NAD -LRB- P -RRB- H oxidase .
18206401	0	oxygen	11,17	VEGF	75,79	oxygen	VEGF	MESH:D010100	100008899(Tax:9986)	Chemical	Gene	results|compound|START_ENTITY results|nmod|vascular_endothelial_growth_factor vascular_endothelial_growth_factor|appos|END_ENTITY	Hyperbaric oxygen results in increased vascular_endothelial_growth_factor -LRB- VEGF -RRB- protein expression in rabbit calvarial critical-sized defects .
18385079	0	oxygen	44,50	VEGF	93,97	oxygen	VEGF	MESH:D010100	7422	Chemical	Gene	oxidase|nmod|START_ENTITY H|amod|oxidase induces|nsubj|H induces|dobj|neovascularization neovascularization|nmod|END_ENTITY	Activated NAD -LRB- P -RRB- H oxidase from supplemental oxygen induces neovascularization independent of VEGF in retinopathy_of_prematurity model .
19298791	0	oxygen	49,55	VEGF	77,81	oxygen	VEGF	MESH:D010100	7422	Chemical	Gene	vessels|nmod|START_ENTITY Response|nmod|vessels Response|dep|modulation modulation|nmod|END_ENTITY	Response of blood vessels in vitro to hyperbaric oxygen -LRB- HBO -RRB- : modulation of VEGF and NO -LRB- x -RRB- release by external lactate or arginine .
21173077	0	oxygen	119,125	VEGF	29,33	oxygen	VEGF	MESH:D010100	7422	Chemical	Gene	species|compound|START_ENTITY production|nmod|species mediated|nmod|production mediated|nsubjpass|stimulation stimulation|nmod|secretion secretion|compound|END_ENTITY	Retinoic_acid stimulation of VEGF secretion from human endometrial stromal cells is mediated by production of reactive oxygen species .
21176170	0	oxygen	25,31	VEGF	101,105	oxygen	VEGF	MESH:D010100	7422	Chemical	Gene	therapy|compound|START_ENTITY impact|nmod|therapy impact|nmod|vascular_endothelial_growth_factor vascular_endothelial_growth_factor|appos|END_ENTITY	The impact of hyperbaric oxygen therapy on serological values of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and basic_fibroblast_growth_factor -LRB- bFGF -RRB- .
21240521	0	oxygen	123,129	VEGF	57,61	oxygen	VEGF	MESH:D010100	281572(Tax:9913)	Chemical	Gene	conditions|compound|START_ENTITY endothelial|nmod|conditions endothelial|nsubj|effect effect|nmod|estrogen estrogen|nmod|expression expression|nmod|END_ENTITY	The contrasting effect of estrogen on mRNA expression of VEGF in bovine retinal_vascular endothelial cells under different oxygen conditions .
22153388	0	oxygen	150,156	VEGF	57,61	oxygen	VEGF	MESH:D010100	7422	Chemical	Gene	production|compound|START_ENTITY inhibition|nmod|production non-small_cell_lung_carcinomas|nmod|inhibition expression|nmod|non-small_cell_lung_carcinomas expression|appos|END_ENTITY	Atorvastatin reduces vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in human non-small_cell_lung_carcinomas -LRB- NSCLCs -RRB- via inhibition of reactive oxygen species -LRB- ROS -RRB- production .
23480207	0	oxygen	9,15	VEGF	62,66	oxygen	VEGF	MESH:D010100	7422	Chemical	Gene	activation|compound|START_ENTITY activation|nmod|results results|nmod|END_ENTITY	Reactive oxygen species activation of MAPK pathway results in VEGF upregulation as an undesired irradiation response .
24183749	0	oxygen	80,86	VEGF	10,14	oxygen	VEGF	MESH:D010100	83785(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY Effect|nmod|treatment Effect|nmod|END_ENTITY	Effect of VEGF and CX43 on the promotion of neurological recovery by hyperbaric oxygen treatment in spinal cord-injured rats .
8670726	0	oxygen	114,120	VEGF	44,48	oxygen	VEGF	MESH:D010100	7422	Chemical	Gene	neovascularization|nmod|START_ENTITY altered|xcomp|neovascularization altered|nsubjpass|expression expression|appos|END_ENTITY	Retinal_vascular_endothelial_growth_factor -LRB- VEGF -RRB- mRNA expression is altered in relation to neovascularization in oxygen induced retinopathy .
15265790	0	oxygen	118,124	Vascular_cell_adhesion_molecule_1	0,33	oxygen	Vascular cell adhesion molecule 1	MESH:D010100	7412	Chemical	Gene	species|compound|START_ENTITY role|nmod|species activation|dep|role activation|amod|END_ENTITY	Vascular_cell_adhesion_molecule_1 -LRB- VCAM-1 -RRB- activation of endothelial cell matrix metalloproteinases : role of reactive oxygen species .
11350731	0	oxygen	80,86	Vascular_endothelial_growth_factor	0,34	oxygen	Vascular endothelial growth factor	MESH:D010100	7422	Chemical	Gene	perturbations|nmod|START_ENTITY adjustments|nmod|perturbations adjustments|compound|END_ENTITY	Vascular_endothelial_growth_factor and vascular adjustments to perturbations in oxygen homeostasis .
12708795	0	oxygen	117,123	Vascular_endothelial_growth_factor	0,34	oxygen	Vascular endothelial growth factor	MESH:D010100	7422	Chemical	Gene	tensions|compound|START_ENTITY release|nmod|tensions release|nsubj|END_ENTITY	Vascular_endothelial_growth_factor and placental_growth_factor release in cultured trophoblast cells under different oxygen tensions .
19236815	0	oxygen	142,148	Vascular_endothelial_growth_factor	0,34	oxygen	Vascular endothelial growth factor	MESH:D010100	281572(Tax:9913)	Chemical	Gene	species|compound|START_ENTITY cells|nmod|species up-regulates|nmod|cells up-regulates|nsubj|END_ENTITY	Vascular_endothelial_growth_factor up-regulates the expression of intracellular_adhesion_molecule-1 in retinal endothelial cells via reactive oxygen species , but not nitric_oxide .
7546767	0	oxygen	100,106	Vascular_endothelial_growth_factor	0,34	oxygen	Vascular endothelial growth factor	MESH:D010100	100008899(Tax:9986)	Chemical	Gene	injury|compound|START_ENTITY recovery|nmod|injury increases|nmod|recovery increases|nsubj|mRNA mRNA|compound|END_ENTITY	Vascular_endothelial_growth_factor mRNA increases in alveolar epithelial cells during recovery from oxygen injury .
12537522	0	oxygen	79,85	Vegf	140,144	oxygen	Vegf	MESH:D010100	22339(Tax:10090)	Chemical	Gene	species|compound|START_ENTITY species|appos|END_ENTITY	Proteinuria and vascular changes after renal irradiation : the role of reactive oxygen species -LRB- ROS -RRB- and vascular_endothelial_growth_factor -LRB- Vegf -RRB- .
25064843	0	oxygen	79,85	WAF1	106,110	oxygen	WAF1	MESH:D010100	1026	Chemical	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Phospholipase_D2 downregulation induces cellular senescence through a reactive oxygen species-p53-p21Cip1 / WAF1 pathway .
22679299	0	oxygen	52,58	X-box_binding_protein_1	15,38	oxygen	X-box binding protein 1	MESH:D010100	7494	Chemical	Gene	species|compound|START_ENTITY species|amod|END_ENTITY	Involvement of X-box_binding_protein_1 and reactive oxygen species pathways in the pathogenesis of tumour necrosis factor_receptor-associated_periodic_syndrome .
9201021	0	oxygen	108,114	activator_protein_1	137,156	oxygen	activator protein 1	MESH:D010100	3725	Chemical	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Cyclic strain-induced monocyte_chemotactic_protein-1 gene expression in endothelial cells involves reactive oxygen species activation of activator_protein_1 .
20207043	0	oxygen	69,75	adenosine_deaminase	19,38	oxygen	adenosine deaminase	MESH:D010100	100	Chemical	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	The role of plasma adenosine_deaminase in chemoattractant-stimulated oxygen radical production in neutrophils .
15535964	0	oxygen	111,117	albumin	61,68	oxygen	albumin	MESH:D010100	24186(Tax:10116)	Chemical	Gene	carrier|compound|START_ENTITY END_ENTITY|nmod|carrier	Physicochemical characterization of cross-linked human serum albumin dimer and its synthetic heme hybrid as an oxygen carrier .
16945391	0	oxygen	9,15	albumin	44,51	oxygen	albumin	MESH:D010100	213	Chemical	Gene	species|compound|START_ENTITY damaged|nsubj|species damaged|dobj|END_ENTITY	Reactive oxygen species damaged human serum albumin in patients with type 1 diabetes_mellitus : biochemical and immunological studies .
25109080	0	oxygen	25,31	albumin	61,68	oxygen	albumin	MESH:D010100	213	Chemical	Gene	therapy|compound|START_ENTITY therapy|nmod|levels levels|compound|END_ENTITY	The effect of hyperbaric oxygen therapy on ischemia-modified albumin levels in people with diabetes with foot ulcers .
15172677	0	oxygen	104,110	alpha-melanocyte-stimulating_hormone	55,91	oxygen	alpha-melanocyte-stimulating hormone	MESH:D010100	24664(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY END_ENTITY|nmod|species	The role of cyclooxygenase inhibition in the effect of alpha-melanocyte-stimulating_hormone on reactive oxygen species production by rat peritoneal neutrophils .
19375411	0	oxygen	53,59	alternative_oxidase	63,82	oxygen	alternative oxidase	MESH:D010100	102588786	Chemical	Gene	Evidence|nmod|START_ENTITY Evidence|nmod|END_ENTITY	Evidence for H -LRB- 2 -RRB- O -LRB- 2 -RRB- as the product of reduction of oxygen by alternative_oxidase in mitochondria from potato tubers .
12176040	0	oxygen	11,17	angiopoietin-2	38,52	oxygen	angiopoietin-2	MESH:D010100	285	Chemical	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Hyperbaric oxygen selectively induces angiopoietin-2 in human umbilical vein endothelial cells .
16298339	0	oxygen	33,39	angiotensin-II	57,71	oxygen	angiotensin-II	MESH:D010100	24179(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY regulate|nsubj|species regulate|dobj|END_ENTITY	NAD -LRB- P -RRB- H oxidase-derived reactive oxygen species regulate angiotensin-II induced adventitial fibroblast phenotypic differentiation .
7937273	0	oxygen	80,86	angiotensin-converting_enzyme	20,49	oxygen	angiotensin-converting enzyme	MESH:D010100	1636	Chemical	Gene	therapy|nmod|START_ENTITY therapy|amod|END_ENTITY	Effect of long-term angiotensin-converting_enzyme inhibitor therapy on arterial oxygen saturation in patients with mild to moderate heart_failure .
10428852	0	oxygen	9,15	angiotensin_II	74,88	oxygen	angiotensin II	MESH:D010100	183	Chemical	Gene	species|compound|START_ENTITY mediate|nsubj|species mediate|dobj|activation activation|nmod|cells cells|amod|kinase_B kinase_B|nmod|END_ENTITY	Reactive oxygen species mediate the activation of Akt/protein _ kinase_B by angiotensin_II in vascular smooth muscle cells .
10764657	0	oxygen	139,145	angiotensin_II	87,101	oxygen	angiotensin II	MESH:D010100	24179(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY involvement|nmod|species activation|dep|involvement activation|nmod|kinases kinases|nmod|cells cells|nmod|END_ENTITY	Differential activation of mitogen-activated protein kinases in smooth muscle cells by angiotensin_II : involvement of p22phox and reactive oxygen species .
10965882	0	oxygen	24,30	angiotensin_II	121,135	oxygen	angiotensin II	MESH:D010100	183	Chemical	Gene	species|compound|START_ENTITY Involvement|nmod|species kinase|nsubj|Involvement kinase|nmod|END_ENTITY	Involvement of reactive oxygen species in the activation of tyrosine kinase and extracellular_signal-regulated_kinase by angiotensin_II .
10967199	0	oxygen	9,15	angiotensin_II	40,54	oxygen	angiotensin II	MESH:D010100	183	Chemical	Gene	species|compound|START_ENTITY Reactive|dobj|species Reactive|nmod|mediators mediators|nmod|END_ENTITY	Reactive oxygen species as mediators of angiotensin_II signaling .
11230331	0	oxygen	9,15	angiotensin_II	101,115	oxygen	angiotensin II	MESH:D010100	24179(Tax:10116)	Chemical	Gene	species-mediated|nsubj|START_ENTITY species-mediated|nmod|END_ENTITY	Reactive oxygen species-mediated homologous downregulation of angiotensin_II_type_1_receptor mRNA by angiotensin_II .
11304462	0	oxygen	85,91	angiotensin_II	52,66	oxygen	angiotensin II	MESH:D010100	183	Chemical	Gene	species|compound|START_ENTITY requires|dobj|species requires|nsubj|transactivation transactivation|nmod|END_ENTITY	Epidermal_growth_factor_receptor transactivation by angiotensin_II requires reactive oxygen species in vascular smooth muscle cells .
11597988	0	oxygen	73,79	angiotensin_II	118,132	oxygen	angiotensin II	MESH:D010100	183	Chemical	Gene	induction|compound|START_ENTITY involved|nmod|induction involved|nmod|END_ENTITY	ERK and p38 MAPK , but not NF-kappaB , are critically involved in reactive oxygen species-mediated induction of IL-6 by angiotensin_II in cardiac fibroblasts .
12573139	0	oxygen	33,39	angiotensin_II	64,78	oxygen	angiotensin II	MESH:D010100	183	Chemical	Gene	species|compound|START_ENTITY H|dobj|species H|nmod|mediators mediators|nmod|END_ENTITY	NAD -LRB- P -RRB- H oxidase-derived reactive oxygen species as mediators of angiotensin_II signaling .
12874088	0	oxygen	36,42	angiotensin_II	8,22	oxygen	angiotensin II	MESH:D010100	24179(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY species|compound|END_ENTITY	Role of angiotensin_II and reactive oxygen species in cyclosporine_A-dependent hypertension .
14588150	0	oxygen	43,49	angiotensin_II	155,169	oxygen	angiotensin II	MESH:D010100	183	Chemical	Gene	species|compound|START_ENTITY kinases|nmod|species Activation|nmod|kinases Activation|dep|significance significance|nmod|EGF_receptor EGF_receptor|acl|transactivation transactivation|nmod|END_ENTITY	Activation of tyrosine kinases by reactive oxygen species in vascular smooth muscle cells : significance and involvement of EGF_receptor transactivation by angiotensin_II .
14755545	0	oxygen	62,68	angiotensin_II	130,144	oxygen	angiotensin II	MESH:D010100	24179(Tax:10116)	Chemical	Gene	induction|compound|START_ENTITY involved|nmod|induction involved|nmod|END_ENTITY	ERK1/2 and JNKs , but not p38 kinase , are involved in reactive oxygen species-mediated induction of osteopontin gene expression by angiotensin_II and interleukin-1beta in adult rat cardiac fibroblasts .
15699441	0	oxygen	30,36	angiotensin_II	85,99	oxygen	angiotensin II	MESH:D010100	24179(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY species|dep|comparison comparison|nmod|END_ENTITY	Mitochondria-derived reactive oxygen species and vascular MAP kinases : comparison of angiotensin_II and diazoxide .
15802620	0	oxygen	23,29	angiotensin_II	98,112	oxygen	angiotensin II	MESH:D010100	183	Chemical	Gene	downregulation|compound|START_ENTITY Mechanisms|nmod|downregulation Mechanisms|nmod|insulin_receptor_substrate-1 insulin_receptor_substrate-1|nmod|END_ENTITY	Mechanisms of reactive oxygen species-dependent downregulation of insulin_receptor_substrate-1 by angiotensin_II .
15824196	0	oxygen	59,65	angiotensin_II	128,142	oxygen	angiotensin II	MESH:D010100	24179(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY reactive|dobj|species reactive|nmod|END_ENTITY	Role of NAD -LRB- P -RRB- H oxidase - and mitochondria-derived reactive oxygen species in cardioprotection of ischemic_reperfusion_injury by angiotensin_II .
16115036	0	oxygen	9,15	angiotensin_II	61,75	oxygen	angiotensin II	MESH:D010100	183	Chemical	Gene	species|compound|START_ENTITY species|nmod|mediators mediators|nmod|calcium calcium|acl|signaling signaling|nmod|END_ENTITY	Reactive oxygen species as mediators of calcium signaling by angiotensin_II : implications in vascular physiology and pathophysiology .
16221213	0	oxygen	70,76	angiotensin_II	37,51	oxygen	angiotensin II	MESH:D010100	24179(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY role|nmod|species Up-regulation|dep|role Up-regulation|nmod|COX-2 COX-2|nmod|END_ENTITY	Up-regulation of glomerular COX-2 by angiotensin_II : role of reactive oxygen species .
16298685	0	oxygen	36,42	angiotensin_II	54,68	oxygen	angiotensin II	MESH:D010100	24179(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY reactive|dobj|species reactive|nmod|END_ENTITY	Activation of AP-1 through reactive oxygen species by angiotensin_II in rat cardiomyocytes .
16505203	0	oxygen	83,89	angiotensin_II	33,47	oxygen	angiotensin II	MESH:D010100	183	Chemical	Gene	species|compound|START_ENTITY role|nmod|species effect|dep|role effect|nmod|END_ENTITY	The positive inotropic effect of angiotensin_II : role of endothelin-1 and reactive oxygen species .
16685210	0	oxygen	25,31	angiotensin_II	141,155	oxygen	angiotensin II	MESH:D010100	24179(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY Contribution|nmod|species Contribution|dep|effects effects|nmod|blockade blockade|amod|END_ENTITY	Contribution of reactive oxygen species to the pathogenesis of left_ventricular_failure in Dahl salt-sensitive hypertensive rats : effects of angiotensin_II blockade .
18094033	0	oxygen	99,105	angiotensin_II	71,85	oxygen	angiotensin II	MESH:D010100	24179(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY species|compound|END_ENTITY	Upregulation of cortical COX-2 in salt-sensitive hypertension : role of angiotensin_II and reactive oxygen species .
18818681	0	oxygen	14,20	angiotensin_II	36,50	oxygen	angiotensin II	MESH:D010100	24179(Tax:10116)	Chemical	Gene	utilization|compound|START_ENTITY Regulation|nmod|utilization Regulation|nmod|END_ENTITY	Regulation of oxygen utilization by angiotensin_II in chronic_kidney_disease .
18854758	0	oxygen	30,36	angiotensin_II	83,97	oxygen	angiotensin II	MESH:D010100	24179(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY mediate|nsubj|species mediate|dobj|sympathoexcitation sympathoexcitation|acl|induced induced|nmod|END_ENTITY	Mitochondria-derived reactive oxygen species mediate sympathoexcitation induced by angiotensin_II in the rostral ventrolateral medulla .
19211495	0	oxygen	94,100	angiotensin_II	49,63	oxygen	angiotensin II	MESH:D010100	11606(Tax:10090)	Chemical	Gene	species|compound|START_ENTITY END_ENTITY|nmod|species	Gender influences cerebral vascular responses to angiotensin_II through Nox2-derived reactive oxygen species .
20626399	0	oxygen	24,30	angiotensin_II	65,79	oxygen	angiotensin II	MESH:D010100	183	Chemical	Gene	species|compound|START_ENTITY Stimulation|nmod|species Stimulation|nmod|END_ENTITY	Stimulation of reactive oxygen species and collagen synthesis by angiotensin_II in cardiac fibroblasts .
21464581	0	oxygen	43,49	angiotensin_II	15,29	oxygen	angiotensin II	MESH:D010100	24179(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY species|compound|END_ENTITY	Involvement of angiotensin_II and reactive oxygen species in pancreatic_fibrosis .
22227335	0	oxygen	21,27	angiotensin_II	84,98	oxygen	angiotensin II	MESH:D010100	24179(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY role|nmod|species induced|nsubj|role induced|nmod|END_ENTITY	The role of reactive oxygen species in the modulation of the contraction induced by angiotensin_II in carotid artery from diabetic rat .
23940049	0	oxygen	189,195	angiotensin_II	142,156	oxygen	angiotensin II	MESH:D010100	183	Chemical	Gene	species|compound|START_ENTITY role|nmod|species END_ENTITY|dep|role	Nox4 NADPH oxidase mediates peroxynitrite-dependent uncoupling of endothelial_nitric-oxide_synthase and fibronectin expression in response to angiotensin_II : role of mitochondrial reactive oxygen species .
25093580	0	oxygen	122,128	angiotensin_II	37,51	oxygen	angiotensin II	MESH:D010100	24179(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY contributes|nmod|production contributes|nsubj|upregulation upregulation|nmod|END_ENTITY	Toll-like_receptor_4 upregulation by angiotensin_II contributes to hypertension and vascular_dysfunction through reactive oxygen species production .
7188389	0	oxygen	28,34	angiotensin_II	48,62	oxygen	angiotensin II	MESH:D010100	24179(Tax:10116)	Chemical	Gene	tension|compound|START_ENTITY tension|nmod|END_ENTITY	Selective increase in tumor oxygen tension with angiotensin_II .
8372242	0	oxygen	56,62	angiotensin_II	76,90	oxygen	angiotensin II	MESH:D010100	183	Chemical	Gene	tension|compound|START_ENTITY tension|nmod|END_ENTITY	New modality of radiation therapy under increased tumor oxygen tension with angiotensin_II : a pilot study .
18595776	0	oxygen	11,17	apolipoprotein_E	84,100	oxygen	apolipoprotein E	MESH:D010100	11816(Tax:10090)	Chemical	Gene	treatment|compound|START_ENTITY attenuates|nsubj|treatment attenuates|dobj|responses responses|nmod|mice mice|amod|END_ENTITY	Hyperbaric oxygen treatment attenuates the pro-inflammatory and immune responses in apolipoprotein_E knockout mice .
24571688	0	oxygen	58,64	apolipoprotein_E	15,31	oxygen	apolipoprotein E	MESH:D010100	348	Chemical	Gene	uptake|compound|START_ENTITY polymorphism|nmod|uptake polymorphism|amod|END_ENTITY	Association of apolipoprotein_E polymorphism with maximal oxygen uptake after exercise training : a study of Chinese young adult .
22784044	0	oxygen	30,36	apoptosis_signal-regulating_kinase_1	54,90	oxygen	apoptosis signal-regulating kinase 1	MESH:D010100	4217	Chemical	Gene	START_ENTITY|dep|activation activation|amod|END_ENTITY	Platycodin_D induces reactive oxygen species-mediated apoptosis_signal-regulating_kinase_1 activation and endoplasmic reticulum stress response in human breast_cancer cells .
25624795	0	oxygen	17,23	aquaporin_4	41,52	oxygen	aquaporin 4	MESH:D010100	100008646(Tax:9986)	Chemical	Gene	therapy|compound|START_ENTITY inhibits|nsubj|therapy inhibits|dobj|expression expression|amod|END_ENTITY	Early hyperbaric oxygen therapy inhibits aquaporin_4 and adrenocorticotropic hormone expression in the pituitary gland of rabbits with blast-induced craniocerebral_injury .
9418241	0	oxygen	81,87	arcA	129,133	oxygen	arcA	MESH:D010100	9845996	Chemical	Gene	response|nmod|START_ENTITY Escherichia_coli|nmod|response expression|nmod|Escherichia_coli Regulation|nmod|expression Regulation|dep|role role|nmod|END_ENTITY	Regulation of fumarase -LRB- fumB -RRB- gene expression in Escherichia_coli in response to oxygen , iron and heme availability : role of the arcA , fur , and hemA gene products .
11568308	0	oxygen	8,14	atrial_natriuretic_peptide	33,59	oxygen	atrial natriuretic peptide	MESH:D010100	24602(Tax:10116)	Chemical	Gene	increases|compound|START_ENTITY END_ENTITY|nsubj|increases	Reduced oxygen tension increases atrial_natriuretic_peptide release from atrial cardiocytes .
28474	0	oxygen	30,36	azoreductase	14,26	oxygen	azoreductase	MESH:D010100	1728	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of azoreductase by oxygen .
21176170	0	oxygen	25,31	bFGF	143,147	oxygen	bFGF	MESH:D010100	2247	Chemical	Gene	therapy|compound|START_ENTITY impact|nmod|therapy impact|nmod|vascular_endothelial_growth_factor vascular_endothelial_growth_factor|appos|END_ENTITY	The impact of hyperbaric oxygen therapy on serological values of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and basic_fibroblast_growth_factor -LRB- bFGF -RRB- .
17322643	0	oxygen	11,17	basic_fibroblast_growth_factor	26,56	oxygen	basic fibroblast growth factor	MESH:D010100	14173(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Hyperbaric oxygen induces basic_fibroblast_growth_factor and hepatocyte_growth_factor expression , and enhances blood perfusion and muscle regeneration in mouse ischemic hind limbs .
18211809	0	oxygen	32,38	bax	18,21	oxygen	bax	MESH:D010100	12028(Tax:10090)	Chemical	Gene	species|compound|START_ENTITY reactive|dobj|species reactive|nmod|END_ENTITY	Interplay between bax , reactive oxygen species production , and cardiolipin oxidation during apoptosis .
8683994	0	oxygen	23,29	bcl-2	136,141	oxygen	bcl-2	MESH:D010100	596	Chemical	Gene	intermediates|compound|START_ENTITY Generation|nmod|intermediates Generation|dep|role role|nmod|END_ENTITY	Generation of reactive oxygen intermediates after treatment of blasts of acute_myeloblastic_leukemia with cytosine_arabinoside : role of bcl-2 .
11322781	0	oxygen	9,15	beta-myosin_heavy_chain	56,79	oxygen	beta-myosin heavy chain	MESH:D010100	29557(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY modulate|nsubj|species modulate|dobj|expression expression|amod|END_ENTITY	Reactive oxygen species modulate angiotensin_II-induced beta-myosin_heavy_chain gene expression via Ras/Raf/extracellular signal-regulated kinase pathway in neonatal rat cardiomyocytes .
15864745	0	oxygen	61,67	beta-myosin_heavy_chain	106,129	oxygen	beta-myosin heavy chain	MESH:D010100	29557(Tax:10116)	Chemical	Gene	pathway|nmod|START_ENTITY Role|nmod|pathway species-mediated|nsubj|Role species-mediated|dobj|expression expression|amod|END_ENTITY	Role of mitogen-activated protein kinase pathway in reactive oxygen species-mediated endothelin-1-induced beta-myosin_heavy_chain gene expression and cardiomyocyte hypertrophy .
17545941	0	oxygen	70,76	c-Jun_N-terminal_kinase	18,41	oxygen	c-Jun N-terminal kinase	MESH:D010100	26419(Tax:10090)	Chemical	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	Hypoxia activates c-Jun_N-terminal_kinase via Rac1-dependent reactive oxygen species production in hepatocytes .
21454558	0	oxygen	125,131	c-Jun_N-terminal_kinase	14,37	oxygen	c-Jun N-terminal kinase	MESH:D010100	5599	Chemical	Gene	generation|compound|START_ENTITY amplification|nmod|generation resulting|nmod|amplification changes|acl|resulting initiates|dobj|changes initiates|nsubj|END_ENTITY	Mitochondrial c-Jun_N-terminal_kinase -LRB- JNK -RRB- signaling initiates physiological changes resulting in amplification of reactive oxygen species generation .
9862355	0	oxygen	23,29	c-Jun_N-terminal_kinase	84,107	oxygen	c-Jun N-terminal kinase	MESH:D010100	26419(Tax:10090)	Chemical	Gene	Production|nmod|START_ENTITY intermediates|nsubj|Production intermediates|nmod|correlates correlates|nmod|activation activation|amod|END_ENTITY	Production of reactive oxygen intermediates following CD40 ligation correlates with c-Jun_N-terminal_kinase activation and IL-6 secretion in murine B lymphocytes .
10435037	0	oxygen	9,15	c-fos	54,59	oxygen	c-fos	MESH:D010100	314322(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY modulate|nsubj|species modulate|dobj|expression expression|amod|END_ENTITY	Reactive oxygen species modulate endothelin-I-induced c-fos gene expression in cardiomyocytes .
12810757	0	oxygen	62,68	c-fos	85,90	oxygen	c-fos	MESH:D010100	2353	Chemical	Gene	START_ENTITY|dobj|expression expression|amod|END_ENTITY	Cyclic_AMP response element-binding protein mediates reactive oxygen species-induced c-fos expression .
1617671	0	oxygen	39,45	c-fos	13,18	oxygen	c-fos	MESH:D010100	14281(Tax:10090)	Chemical	Gene	induction|nmod|START_ENTITY induction|nsubj|Mechanism Mechanism|nmod|END_ENTITY	Mechanism of c-fos induction by active oxygen .
20663035	0	oxygen	109,115	c-fos	61,66	oxygen	c-fos	MESH:D010100	314322(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY species|amod|END_ENTITY	Effect of gamma-glutamylcysteine_ethylester on the levels of c-fos mRNA expression , glutathione and reactive oxygen species formation in kainic_acid excitotoxicity .
7744816	0	oxygen	24,30	c-fos	82,87	oxygen	c-fos	MESH:D010100	2353	Chemical	Gene	species|compound|START_ENTITY Involvement|nmod|species Involvement|nmod|expression expression|amod|END_ENTITY	Involvement of reactive oxygen species in cytokine and growth factor induction of c-fos expression in chondrocytes .
9525474	0	oxygen	21,27	c-fos	117,122	oxygen	c-fos	MESH:D010100	2353	Chemical	Gene	species|compound|START_ENTITY Increase|nmod|species Increase|nmod|flow flow|nmod|ROS ROS|nmod|expression expression|amod|END_ENTITY	Increase of reactive oxygen species -LRB- ROS -RRB- in endothelial cells by shear flow and involvement of ROS in shear-induced c-fos expression .
14756677	0	oxygen	70,76	calcitonin_gene-related_peptide	14,45	oxygen	calcitonin gene-related peptide	MESH:D010100	24241(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY species|amod|END_ENTITY	Importance of calcitonin_gene-related_peptide , adenosine and reactive oxygen species in cerebral autoregulation under normal and diseased conditions .
22964219	0	oxygen	36,42	caspase_8	13,22	oxygen	caspase 8	MESH:D010100	12370(Tax:10090)	Chemical	Gene	species|compound|START_ENTITY species|amod|END_ENTITY	Induction of caspase_8 and reactive oxygen species by ruthenium-derived anticancer compounds with improved water solubility and cytotoxicity .
10628300	0	oxygen	39,45	catalase	19,27	oxygen	catalase	MESH:D010100	847	Chemical	Gene	Oxidation|nmod|START_ENTITY Oxidation|nmod|END_ENTITY	Oxidation of human catalase by singlet oxygen in myeloid_leukemia cells .
12730222	0	oxygen	44,50	catalase	80,88	oxygen	catalase	MESH:D010100	847	Chemical	Gene	species|compound|START_ENTITY production|nmod|species production|dep|role role|nmod|END_ENTITY	UVB light stimulates production of reactive oxygen species : unexpected role for catalase .
16346737	0	oxygen	35,41	catalase	87,95	oxygen	catalase	MESH:D010100	847	Chemical	Gene	addition|nmod|START_ENTITY Quantitative|dobj|addition Quantitative|nmod|use use|nmod|END_ENTITY	Quantitative addition of dissolved oxygen to in situ benthic chamber systems by use of catalase and hydrogen_peroxide .
17186497	0	oxygen	39,45	catalase	18,26	oxygen	catalase	MESH:D010100	847	Chemical	Gene	species|compound|START_ENTITY END_ENTITY|nmod|species	Downregulation of catalase by reactive oxygen species via PI 3 kinase/Akt signaling in mesangial cells .
18816030	0	oxygen	34,40	catalase	53,61	oxygen	catalase	MESH:D010100	847	Chemical	Gene	state|nmod|START_ENTITY released|nsubj|state released|nmod|END_ENTITY	Electronic state of the molecular oxygen released by catalase .
18967474	0	oxygen	112,118	catalase	67,75	oxygen	catalase	MESH:D010100	847	Chemical	Gene	probe|compound|START_ENTITY based|nmod|probe electrode|acl|based electrode|amod|END_ENTITY	A novel biosensor for specific determination of hydrogen_peroxide : catalase enzyme electrode based on dissolved oxygen probe .
20416298	0	oxygen	39,45	catalase	18,26	oxygen	catalase	MESH:D010100	847	Chemical	Gene	species|compound|START_ENTITY Downregulation|nmod|species Downregulation|nmod|END_ENTITY	Downregulation of catalase by reactive oxygen species via hypermethylation of CpG island II on the catalase promoter .
20416298	0	oxygen	39,45	catalase	99,107	oxygen	catalase	MESH:D010100	847	Chemical	Gene	species|compound|START_ENTITY Downregulation|nmod|species Downregulation|nmod|II II|nmod|promoter promoter|amod|END_ENTITY	Downregulation of catalase by reactive oxygen species via hypermethylation of CpG island II on the catalase promoter .
21183538	0	oxygen	67,73	catalase	96,104	oxygen	catalase	MESH:D010100	847	Chemical	Gene	species|compound|START_ENTITY system|nmod|species activity|nmod|system Modulation|nmod|activity Modulation|dep|influence influence|nmod|END_ENTITY	Modulation of the activity of the NADPH oxidase system by reactive oxygen species : influence of catalase .
21408075	0	oxygen	9,15	catalase	38,46	oxygen	catalase	MESH:D010100	40048(Tax:7227)	Chemical	Gene	species|compound|START_ENTITY species|acl|scavenging scavenging|nmod|END_ENTITY	Reactive oxygen species scavenging by catalase is important for female Lutzomyia longipalpis fecundity and mortality .
21455844	0	oxygen	19,25	catalase	59,67	oxygen	catalase	MESH:D010100	847	Chemical	Gene	species|compound|START_ENTITY species|dep|level level|compound|END_ENTITY	Increased reactive oxygen species -LRB- ROS -RRB- production and low catalase level in fibroblasts of a girl with MEGDEL association -LRB- Leigh_syndrome , deafness , 3-methylglutaconic aciduria -RRB- .
21497591	0	oxygen	46,52	catalase	114,122	oxygen	catalase	MESH:D010100	847	Chemical	Gene	species|compound|START_ENTITY reduces|iobj|species reduces|advcl|upregulating upregulating|dobj|expression expression|amod|END_ENTITY	Hydroxytyrosol reduces intracellular reactive oxygen species levels in vascular endothelial cells by upregulating catalase expression through the AMPK-FOXO3a pathway .
21985966	0	oxygen	9,15	catalase	37,45	oxygen	catalase	MESH:D010100	847	Chemical	Gene	species|compound|START_ENTITY downregulate|nsubj|species downregulate|dobj|expression expression|amod|END_ENTITY	Reactive oxygen species downregulate catalase expression via methylation of a CpG island in the Oct-1 promoter .
4020882	0	oxygen	62,68	catalase	119,127	oxygen	catalase	MESH:D010100	847	Chemical	Gene	paradox|compound|START_ENTITY radical|nmod|paradox Involvement|nmod|radical Involvement|dep|reduction reduction|nmod|release release|nmod|END_ENTITY	Involvement of hydrogen_peroxide and hydroxyl radical in the ` oxygen paradox ' : reduction of creatine kinase release by catalase , allopurinol or deferoxamine , but not by superoxide dismutase .
6091498	0	oxygen	21,27	catalase	117,125	oxygen	catalase	MESH:D010100	847	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of molecular oxygen on detection of superoxide radical with nitroblue_tetrazolium and on activity stains for catalase .
6690485	0	oxygen	19,25	catalase	82,90	oxygen	catalase	MESH:D010100	24248(Tax:10116)	Chemical	Gene	toxicity|compound|START_ENTITY toxicity|nmod|injection injection|nmod|END_ENTITY	Protection against oxygen toxicity by intravenous injection of liposome-entrapped catalase and superoxide dismutase .
7327241	0	oxygen	75,81	catalase	11,19	oxygen	catalase	MESH:D010100	24248(Tax:10116)	Chemical	Gene	radicals|compound|START_ENTITY Effects|nmod|radicals Effects|nmod|END_ENTITY	Effects of catalase , peroxidase , superoxide dismutase and 10 scavengers of oxygen radicals in carrageenin edema and in adjuvant_arthritis of rats .
9034240	0	oxygen	112,118	catalase	145,153	oxygen	catalase	MESH:D010100	847	Chemical	Gene	species|compound|START_ENTITY species|nmod|suppression suppression|nmod|peroxidase peroxidase|amod|END_ENTITY	TGF-beta1 triggers oxidative modifications and enhances apoptosis in HIT cells through accumulation of reactive oxygen species by suppression of catalase and glutathione peroxidase .
14654753	0	oxygen	70,76	coupling_factor_6	12,29	oxygen	Coupling factor 6	MESH:D010100	522	Chemical	Gene	species|compound|START_ENTITY role|nmod|species END_ENTITY|dep|role	Circulating coupling_factor_6 in human hypertension : role of reactive oxygen species .
11374891	0	oxygen	9,15	cyclooxygenase-2	37,53	oxygen	cyclooxygenase-2	MESH:D010100	282023(Tax:9913)	Chemical	Gene	species|compound|START_ENTITY up-regulates|nsubj|species up-regulates|dobj|END_ENTITY	Reactive oxygen species up-regulates cyclooxygenase-2 , p53 , and Bax mRNA expression in bovine luteal cells .
12453435	0	oxygen	4,10	cyclooxygenase-2	92,108	oxygen	cyclooxygenase-2	MESH:D010100	19225(Tax:10090)	Chemical	Gene	pyrrolidine_dithiocarbamate|amod|START_ENTITY enhances|nsubj|pyrrolidine_dithiocarbamate enhances|dobj|expression expression|amod|END_ENTITY	The oxygen radical scavenger pyrrolidine_dithiocarbamate enhances interleukin-1beta-induced cyclooxygenase-2 expression in cerebral microvascular smooth muscle cells .
14514642	0	oxygen	9,15	cyclooxygenase-2	49,65	oxygen	cyclooxygenase-2	MESH:D010100	5743	Chemical	Gene	species|compound|START_ENTITY species|nmod|expression expression|amod|END_ENTITY	Reactive oxygen species from mitochondria induce cyclooxygenase-2 gene expression in human mesangial cells : potential role in diabetic_nephropathy .
14522422	0	oxygen	9,15	cyclooxygenase-2	32,48	oxygen	cyclooxygenase-2	MESH:D010100	5743	Chemical	Gene	species|compound|START_ENTITY mediate|nsubj|species mediate|dobj|induction induction|amod|END_ENTITY	Reactive oxygen species mediate cyclooxygenase-2 induction during monocyte to macrophage differentiation : critical role of NADPH oxidase .
15767259	0	oxygen	126,132	cyclooxygenase-2	50,66	oxygen	cyclooxygenase-2	MESH:D010100	5743	Chemical	Gene	species|compound|START_ENTITY colonocytes|nmod|species END_ENTITY|nmod|colonocytes	Clostridium_difficile toxin A regulates inducible cyclooxygenase-2 and prostaglandin_E2 synthesis in colonocytes via reactive oxygen species and activation of p38_MAPK .
15838313	0	oxygen	76,82	cyclooxygenase-2	21,37	oxygen	cyclooxygenase-2	MESH:D010100	29527(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY expression|nmod|species expression|amod|END_ENTITY	Endothelin-1 induces cyclooxygenase-2 expression and generation of reactive oxygen species in endothelial cells .
16195339	0	oxygen	102,108	cyclooxygenase-2	30,46	oxygen	cyclooxygenase-2	MESH:D010100	5743	Chemical	Gene	signaling|nsubj|START_ENTITY involves|xcomp|signaling involves|nsubj|regulation regulation|nmod|inhibitors inhibitors|amod|END_ENTITY	Transcriptional regulation of cyclooxygenase-2 in response to proteasome inhibitors involves reactive oxygen species-mediated signaling pathway and recruitment of CCAAT/enhancer-binding _ protein_delta and CREB-binding_protein .
16638581	0	oxygen	147,153	cyclooxygenase-2	85,101	oxygen	cyclooxygenase-2	MESH:D010100	5743	Chemical	Gene	species|compound|START_ENTITY abolished|nmod|species abolished|nsubjpass|proliferation proliferation|nmod|overexpression overexpression|amod|END_ENTITY	Inhibition of platelet-derived growth factor-induced mesangial cell proliferation by cyclooxygenase-2 overexpression is abolished through reactive oxygen species .
16917206	0	oxygen	97,103	cyclooxygenase-2	49,65	oxygen	cyclooxygenase-2	MESH:D010100	5743	Chemical	Gene	species|compound|START_ENTITY species|compound|END_ENTITY	Celecoxib can induce cell death independently of cyclooxygenase-2 , p53 , Mdm2 , c-Abl and reactive oxygen species .
17082565	0	oxygen	134,140	cyclooxygenase-2	89,105	oxygen	cyclooxygenase-2	MESH:D010100	5743	Chemical	Gene	generation|compound|START_ENTITY modulates|nmod|generation modulates|dobj|expression expression|amod|END_ENTITY	An environmental quinoid polycyclic_aromatic_hydrocarbon , acenaphthenequinone , modulates cyclooxygenase-2 expression through reactive oxygen species generation and nuclear_factor_kappa_B activation in A549 cells .
17645304	0	oxygen	84,90	cyclooxygenase-2	16,32	oxygen	cyclooxygenase-2	MESH:D010100	29527(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY species|amod|END_ENTITY	Upregulation of cyclooxygenase-2 by motorcycle exhaust particulate-induced reactive oxygen species enhances rat vascular smooth muscle cell proliferation .
20940016	0	oxygen	144,150	cyclooxygenase-2	49,65	oxygen	cyclooxygenase-2	MESH:D010100	29527(Tax:10116)	Chemical	Gene	reduction|compound|START_ENTITY reduction|amod|END_ENTITY	Dipyridamole inhibits lipopolysaccharide-induced cyclooxygenase-2 and monocyte_chemoattractant_protein-1 via heme_oxygenase-1-mediated reactive oxygen species reduction in rat mesangial cells .
7706475	0	oxygen	24,30	cyclooxygenase-2	48,64	oxygen	cyclooxygenase-2	MESH:D010100	29527(Tax:10116)	Chemical	Gene	intermediates|compound|START_ENTITY intermediates|nmod|expression expression|amod|END_ENTITY	Involvement of reactive oxygen intermediates in cyclooxygenase-2 expression induced by interleukin-1 , _ tumor_necrosis_factor-alpha , and lipopolysaccharide .
1687018	1	oxygen	108,114	cytochrome_P-450	78,94	oxygen	cytochrome P-450	MESH:D010100	25251(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY species|amod|END_ENTITY	Role of cytochrome_P-450 and reactive oxygen species .
2012803	0	oxygen	11,17	cytochrome_P-450	57,73	oxygen	cytochrome P-450	MESH:D010100	25251(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|photodissociability photodissociability|nmod|END_ENTITY	Effects of oxygen on the relative photodissociability of cytochrome_P-450 .
2495190	1	oxygen	67,73	cytochrome_P-450	93,109	oxygen	cytochrome P-450	MESH:D010100	25251(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Inhibitory effect of oxygen and involvement of cytochrome_P-450 .
2600595	0	oxygen	96,102	cytochrome_P-450	52,68	oxygen	cytochrome P-450	MESH:D010100	4051	Chemical	Gene	consumption|compound|START_ENTITY kinetics|nmod|consumption Demethylation|dep|kinetics Demethylation|nmod|tertiary_amines tertiary_amines|nmod|system system|amod|END_ENTITY	Demethylation of tertiary_amines by a reconstituted cytochrome_P-450 enzyme system : kinetics of oxygen consumption and hydrogen_peroxide formation .
2609348	0	oxygen	131,137	cytochrome_P-450	80,96	oxygen	cytochrome P-450	MESH:D010100	25251(Tax:10116)	Chemical	Gene	microsomes|nmod|START_ENTITY END_ENTITY|nmod|microsomes	Halomethane hepatotoxicity : induction of lipid peroxidation and inactivation of cytochrome_P-450 in rat liver microsomes under low oxygen partial pressures .
2830813	0	oxygen	23,29	cytochrome_P-450	54,70	oxygen	cytochrome P-450	MESH:D010100	25251(Tax:10116)	Chemical	Gene	toxicity|compound|START_ENTITY Protection|nmod|toxicity Protection|nmod|inducers inducers|nmod|system system|amod|END_ENTITY	Protection of rat from oxygen toxicity by inducers of cytochrome_P-450 system .
2981610	0	oxygen	15,21	cytochrome_P-450	68,84	oxygen	cytochrome P-450	MESH:D010100	25251(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY Role|nmod|species Role|nmod|photodestruction photodestruction|nmod|END_ENTITY	Role of active oxygen species in the photodestruction of microsomal cytochrome_P-450 and associated monooxygenases by hematoporphyrin derivative in rats .
3377780	0	oxygen	33,39	cytochrome_P-450	69,85	oxygen	cytochrome P-450	MESH:D010100	25251(Tax:10116)	Chemical	Gene	metabolism|nmod|START_ENTITY Inhibition|nmod|metabolism varies|nsubj|Inhibition varies|nmod|isoenzymes isoenzymes|nmod|END_ENTITY	Inhibition of CCl4 metabolism by oxygen varies between isoenzymes of cytochrome_P-450 .
3600619	0	oxygen	97,103	cytochrome_P-450	39,55	oxygen	cytochrome P-450	MESH:D010100	4051	Chemical	Gene	-RSB-|compound|START_ENTITY factors|nmod|-RSB- factors|nmod|properties properties|nmod|END_ENTITY	-LSB- Electron factors in the properties of cytochrome_P-450 and mechanism of activation of molecular oxygen -RSB- .
3862132	0	oxygen	23,29	cytochrome_P-450	59,75	oxygen	cytochrome P-450	MESH:D010100	13079(Tax:10090)	Chemical	Gene	toxicity|compound|START_ENTITY differences|nmod|toxicity correlated|nsubjpass|differences correlated|nmod|inducibility inducibility|amod|END_ENTITY	Genetic differences in oxygen toxicity are correlated with cytochrome_P-450 inducibility .
420819	0	oxygen	30,36	cytochrome_P-450	47,63	oxygen	cytochrome P-450	MESH:D010100	25251(Tax:10116)	Chemical	Gene	donors|compound|START_ENTITY donors|nmod|catalyzed catalyzed|amod|END_ENTITY	Iodosylbenzene derivatives as oxygen donors in cytochrome_P-450 catalyzed steroid hydroxylations .
42252	0	oxygen	38,44	cytochrome_P-450	59,75	oxygen	cytochrome P-450	MESH:D010100	4051	Chemical	Gene	investigations|nmod|START_ENTITY activation|nsubj|investigations activation|advcl|END_ENTITY	Electrochemical investigations on the oxygen activation by cytochrome_P-450 .
6326394	0	oxygen	17,23	cytochrome_P-450	81,97	oxygen	cytochrome P-450	MESH:D010100	4051	Chemical	Gene	ligation|compound|START_ENTITY ligation|nmod|properties properties|nmod|END_ENTITY	The influence of oxygen donor ligation on the spectroscopic properties of ferric cytochrome_P-450 : ester , ether and ketone co-ordination to the haem iron .
6587349	0	oxygen	73,79	cytochrome_P-450	26,42	oxygen	cytochrome P-450	MESH:D010100	4051	Chemical	Gene	transfer|compound|START_ENTITY mechanism|nmod|transfer Epoxidation|dep|mechanism Epoxidation|nmod|olefins olefins|nmod|compounds compounds|amod|END_ENTITY	Epoxidation of olefins by cytochrome_P-450 model compounds : mechanism of oxygen atom transfer .
8600980	0	oxygen	81,87	cytochrome_P-450	8,24	oxygen	cytochrome P-450	MESH:D010100	25251(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY Role|nmod|species Role|nmod|END_ENTITY	Role of cytochrome_P-450 in the stimulation of microsomal production of reactive oxygen species by ferritin .
17718406	0	oxygen	71,77	cytochrome_P450_2E1	103,122	oxygen	cytochrome P450 2E1	MESH:D010100	1571	Chemical	Gene	generation|compound|START_ENTITY generation|nmod|END_ENTITY	Alcohol metabolism 's damaging effects on the cell : a focus on reactive oxygen generation by the enzyme cytochrome_P450_2E1 .
17276741	0	oxygen	45,51	cytochrome_c	24,36	oxygen	cytochrome c	MESH:D010100	54205	Chemical	Gene	toxicity|compound|START_ENTITY END_ENTITY|nmod|toxicity	Detoxifying function of cytochrome_c against oxygen toxicity .
17497889	0	oxygen	8,14	cytochrome_c	90,102	oxygen	cytochrome c	MESH:D010100	54205	Chemical	Gene	generation|compound|START_ENTITY generation|nmod|END_ENTITY	Singlet oxygen generation from the decomposition of alpha-linolenic_acid_hydroperoxide by cytochrome_c and lactoperoxidase .
21211514	0	oxygen	34,40	cytochrome_c	44,56	oxygen	cytochrome c	MESH:D010100	54205	Chemical	Gene	START_ENTITY|nmod|oxidase oxidase|amod|END_ENTITY	Explaining the enigmatic K -LRB- M -RRB- for oxygen in cytochrome_c oxidase : a kinetic model .
8702521	0	oxygen	10,16	cytochrome_c_oxidase	27,47	oxygen	cytochrome c oxidase	MESH:D010100	282199(Tax:9913)	Chemical	Gene	modulates|compound|START_ENTITY END_ENTITY|nsubj|modulates	Molecular oxygen modulates cytochrome_c_oxidase function .
22231145	0	oxygen	130,136	cytosolic_phospholipase_A2	51,77	oxygen	cytosolic phospholipase A2	MESH:D010100	18783(Tax:10090)	Chemical	Gene	species/activator|compound|START_ENTITY decrease|nmod|species/activator expression|nmod|decrease expression|amod|END_ENTITY	Heme_oxygenase_1 attenuates interleukin-1b-induced cytosolic_phospholipase_A2 expression via a decrease in NADPH oxidase/reactive oxygen species/activator _ protein_1 activation in rheumatoid_arthritis synovial fibroblasts .
18164688	0	oxygen	109,115	death_receptor_5	150,166	oxygen	death receptor 5	MESH:D010100	8795	Chemical	Gene	up-regulation|compound|START_ENTITY up-regulation|nmod|END_ENTITY	Rosiglitazone promotes tumor_necrosis_factor-related_apoptosis-inducing_ligand-induced apoptosis by reactive oxygen species-mediated up-regulation of death_receptor_5 and down-regulation of c-FLIP .
19345731	0	oxygen	65,71	death_receptor_5	106,122	oxygen	death receptor 5	MESH:D010100	8795	Chemical	Gene	up-regulation|compound|START_ENTITY up-regulation|nmod|END_ENTITY	Withaferin_A sensitizes TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of death_receptor_5 and down-regulation of c-FLIP .
18821853	0	oxygen	11,17	discoidin_domain_receptor_2	28,55	oxygen	discoidin domain receptor 2	MESH:D010100	685781(Tax:10116)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Hyperbaric oxygen activates discoidin_domain_receptor_2 via tumour necrosis factor-alpha and the p38 MAPK pathway to increase vascular smooth muscle cell migration through matrix_metalloproteinase_2 .
16293798	4	oxygen	505,511	eNOS	523,527	oxygen	eNOS	MESH:D010100	4846	Chemical	Gene	species|compound|START_ENTITY reactive|dobj|species reactive|nmod|END_ENTITY	As the switch from NO production to reactive oxygen species by eNOS is also the final common pathway in atherogenesis , the uncoupling of eNOS further builds on the hypothesis that atherogenesis is driven by cellular mechanisms that originally serve host defense .
19797052	0	oxygen	125,131	eNOS	147,151	oxygen	eNOS	MESH:D010100	4846	Chemical	Gene	species|compound|START_ENTITY species|appos|END_ENTITY	Active NF-E2-related_factor -LRB- Nrf2 -RRB- contributes to keep endothelial NO synthase -LRB- eNOS -RRB- in the coupled state : role of reactive oxygen species -LRB- ROS -RRB- , eNOS , and heme oxygenase -LRB- HO-1 -RRB- levels .
11860423	0	oxygen	9,15	elastin	43,50	oxygen	elastin	MESH:D010100	2006	Chemical	Gene	species|compound|START_ENTITY activate|nsubj|species activate|dobj|promoter promoter|compound|END_ENTITY	Reactive oxygen species activate the human elastin promoter in a transgenic model of cutaneous_photoaging .
9165309	0	oxygen	19,25	elastin	41,48	oxygen	elastin	MESH:D010100	2006	Chemical	Gene	species|compound|START_ENTITY species|nmod|expression expression|amod|END_ENTITY	Effect of reactive oxygen species on the elastin mRNA expression in cultured human dermal fibroblasts .
10779046	0	oxygen	9,15	endothelin-1	33,45	oxygen	endothelin-1	MESH:D010100	24323(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY enhances|nsubj|species enhances|dobj|production production|amod|END_ENTITY	Reactive oxygen species enhances endothelin-1 production of diabetic rat glomeruli in vitro and in vivo .
10844830	0	oxygen	9,15	endothelin-1	100,112	oxygen	endothelin-1	MESH:D010100	1906	Chemical	Gene	fraction|compound|START_ENTITY fraction|dep|effects effects|nmod|function function|nmod|regard regard|nmod|concentrations concentrations|amod|END_ENTITY	Inspired oxygen fraction after cardiopulmonary bypass : effects on pulmonary function with regard to endothelin-1 concentrations and venous admixture .
11603923	0	oxygen	9,15	endothelin-1	54,66	oxygen	endothelin-1	MESH:D010100	1906	Chemical	Gene	species|compound|START_ENTITY mediate|nsubj|species mediate|dobj|expression expression|amod|END_ENTITY	Reactive oxygen species mediate cyclic strain-induced endothelin-1 gene expression via Ras/Raf/extracellular signal-regulated kinase pathway in endothelial cells .
11853865	0	oxygen	46,52	endothelin-1	10,22	oxygen	endothelin-1	MESH:D010100	24323(Tax:10116)	Chemical	Gene	balance|compound|START_ENTITY improves|dobj|balance improves|nsubj|Exogenous Exogenous|amod|END_ENTITY	Exogenous endothelin-1 improves microvascular oxygen balance during focal cerebral_ischemia in the rat .
12132518	0	oxygen	106,112	endothelin-1	22,34	oxygen	endothelin-1	MESH:D010100	1906	Chemical	Gene	breathing|nmod|START_ENTITY increase|nmod|breathing increase|nmod|levels levels|amod|END_ENTITY	Transient increase in endothelin-1 levels in the pulmonary circulation during exercise while breathing of oxygen in patients with chronic_obstructive_pulmonary_disease .
12695528	0	oxygen	74,80	endothelin-1	138,150	oxygen	endothelin-1	MESH:D010100	24323(Tax:10116)	Chemical	Gene	pathway|nmod|START_ENTITY role|nmod|pathway species-mediated|nsubj|role species-mediated|dobj|expression expression|acl|induced induced|nmod|fibroblasts fibroblasts|amod|END_ENTITY	Crucial role of extracellular_signal-regulated_kinase pathway in reactive oxygen species-mediated endothelin-1 gene expression induced by endothelin-1 in rat cardiac fibroblasts .
12695528	0	oxygen	74,80	endothelin-1	98,110	oxygen	endothelin-1	MESH:D010100	24323(Tax:10116)	Chemical	Gene	pathway|nmod|START_ENTITY role|nmod|pathway species-mediated|nsubj|role species-mediated|dobj|expression expression|amod|END_ENTITY	Crucial role of extracellular_signal-regulated_kinase pathway in reactive oxygen species-mediated endothelin-1 gene expression induced by endothelin-1 in rat cardiac fibroblasts .
1445378	0	oxygen	80,86	endothelin-1	49,61	oxygen	endothelin-1	MESH:D010100	1906	Chemical	Gene	Decrease|nmod|START_ENTITY Decrease|nmod|immunoreactivity immunoreactivity|nmod|END_ENTITY	Decrease in immunoreactivity and vasoactivity of endothelin-1 after exposure to oxygen .
14642698	0	oxygen	24,30	endothelin-1	65,77	oxygen	endothelin-1	MESH:D010100	24323(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY Involvement|nmod|species Involvement|nmod|expression expression|amod|END_ENTITY	Involvement of reactive oxygen species in angiotensin_II-induced endothelin-1 gene expression in rat cardiac fibroblasts .
14730203	0	oxygen	17,23	endothelin-1	114,126	oxygen	endothelin-1	MESH:D010100	1906	Chemical	Gene	Role|nmod|START_ENTITY species-sensitive|nsubj|Role species-sensitive|nmod|expression expression|amod|END_ENTITY	Role of reactive oxygen species-sensitive extracellular_signal-regulated_kinase pathway in angiotensin_II-induced endothelin-1 gene expression in vascular endothelial cells .
15224158	0	oxygen	10,16	endothelin-1	94,106	oxygen	endothelin-1	MESH:D010100	24323(Tax:10116)	Chemical	Gene	mediate|compound|START_ENTITY cultured|nsubj|mediate cultured|dobj|myocyte myocyte|acl|induced induced|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Reactive oxygen species mediate cultured neonatal rat cardiac myocyte hypertrophy induced by endothelin-1 -RSB- .
15608082	0	oxygen	71,77	endothelin-1	107,119	oxygen	endothelin-1	MESH:D010100	1906	Chemical	Gene	species|compound|START_ENTITY species|dep|role role|nmod|END_ENTITY	Vascular_dysfunction of venous bypass conduits is mediated by reactive oxygen species in diabetes : role of endothelin-1 .
16391241	0	oxygen	9,15	endothelin-1	186,198	oxygen	endothelin-1	MESH:D010100	24323(Tax:10116)	Chemical	Gene	generation|compound|START_ENTITY involved|nsubjpass|generation involved|nmod|oxidization oxidization|nmod|fibroblasts fibroblasts|amod|Src_homology_2-containing_tyrosine_phosphatase Src_homology_2-containing_tyrosine_phosphatase|nmod|END_ENTITY	Reactive oxygen species generation is involved in epidermal_growth_factor_receptor transactivation through the transient oxidization of Src_homology_2-containing_tyrosine_phosphatase in endothelin-1 signaling pathway in rat cardiac fibroblasts .
16410680	0	oxygen	86,92	endothelin-1	21,33	oxygen	endothelin-1	MESH:D010100	281137(Tax:9913)	Chemical	Gene	production|compound|START_ENTITY dependent|nmod|production dependent|nsubj|release release|amod|END_ENTITY	Homocysteine-induced endothelin-1 release is dependent on hyperglycaemia and reactive oxygen species production in bovine aortic endothelial cells .
16505203	0	oxygen	83,89	endothelin-1	57,69	oxygen	endothelin-1	MESH:D010100	1906	Chemical	Gene	species|compound|START_ENTITY species|amod|END_ENTITY	The positive inotropic effect of angiotensin_II : role of endothelin-1 and reactive oxygen species .
18398338	0	oxygen	9,15	endothelin-1	73,85	oxygen	endothelin-1	MESH:D010100	1906	Chemical	Gene	species|compound|START_ENTITY oxidized|nsubj|species oxidized|dobj|expression expression|amod|END_ENTITY	Reactive oxygen species mediate oxidized low-density lipoprotein-induced endothelin-1 gene expression via extracellular_signal-regulated_kinase in vascular endothelial cells .
18625248	0	oxygen	84,90	endothelin-1	33,45	oxygen	endothelin-1	MESH:D010100	1906	Chemical	Gene	species|compound|START_ENTITY mediated|nmod|species mediated|nsubjpass|effect effect|nmod|END_ENTITY	The positive inotropic effect of endothelin-1 is mediated by mitochondrial reactive oxygen species .
19623039	0	oxygen	43,49	endothelin-1	17,29	oxygen	endothelin-1	MESH:D010100	1906	Chemical	Gene	species|compound|START_ENTITY species|amod|END_ENTITY	Novel pathway of endothelin-1 and reactive oxygen species in coronary_vasospasm with endothelial_dysfunction .
24239798	0	oxygen	51,57	endothelin-1	93,105	oxygen	endothelin-1	MESH:D010100	13614(Tax:10090)	Chemical	Gene	species|compound|START_ENTITY increases|nmod|species activate|nsubj|increases activate|dep|increasing increasing|dobj|reactivity reactivity|amod|END_ENTITY	Intermittent hypoxia-induced increases in reactive oxygen species activate NFATc3 increasing endothelin-1 vasoconstrictor reactivity .
25932745	0	oxygen	100,106	endothelin-1	40,52	oxygen	endothelin-1	MESH:D010100	1906	Chemical	Gene	generation|compound|START_ENTITY suppression|nmod|generation inhibits|nmod|suppression inhibits|dobj|expression expression|amod|END_ENTITY	Lycopene inhibits cyclic strain-induced endothelin-1 expression through the suppression of reactive oxygen species generation and induction of heme_oxygenase-1 in human umbilical vein endothelial cells .
8060347	0	oxygen	4,10	endothelin-1	20,32	oxygen	endothelin-1	MESH:D010100	24323(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|amod|END_ENTITY	Low oxygen enhances endothelin-1 -LRB- ET-1 -RRB- production and responsiveness to ET-1 in cultured cardiac myocytes .
8770966	0	oxygen	19,25	endothelin-1	37,49	oxygen	endothelin-1	MESH:D010100	1906	Chemical	Gene	species|compound|START_ENTITY Effect|nmod|species Effect|nmod|production production|amod|END_ENTITY	Effect of reactive oxygen species on endothelin-1 production by human mesangial cells .
9051826	0	oxygen	58,64	endothelin-1	13,25	oxygen	endothelin-1	MESH:D010100	403424(Tax:9615)	Chemical	Gene	metabolism|compound|START_ENTITY Effect|nmod|metabolism Effect|nmod|antagonist antagonist|amod|END_ENTITY	Effect of an endothelin-1 antagonist , BQ-485 , on cerebral oxygen metabolism after complete global cerebral_ischemia in dogs .
9595536	0	oxygen	14,20	endothelin-1	54,66	oxygen	endothelin-1	MESH:D010100	1906	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|production production|amod|END_ENTITY	The effect of oxygen and carbon_dioxide on tumor cell endothelin-1 production .
9641261	0	oxygen	44,50	endothelin-1	62,74	oxygen	endothelin-1	MESH:D010100	281137(Tax:9913)	Chemical	Gene	species|compound|START_ENTITY effects|nmod|species effects|nmod|secretion secretion|amod|END_ENTITY	Cytotoxicity-associated effects of reactive oxygen species on endothelin-1 secretion by pulmonary endothelial cells .
9662270	0	oxygen	76,82	endothelin-1	16,28	oxygen	endothelin-1	MESH:D010100	1906	Chemical	Gene	relationships|nmod|START_ENTITY levels|dep|relationships levels|amod|END_ENTITY	Elevated plasma endothelin-1 levels in sickle_cell_anemia : relationships to oxygen saturation and left ventricular_hypertrophy .
10385683	0	oxygen	173,179	epidermal_growth_factor	134,157	oxygen	epidermal growth factor	MESH:D010100	25313(Tax:10116)	Chemical	Gene	tension|compound|START_ENTITY tension|compound|END_ENTITY	Mimicry in primary rat hepatocyte cultures of the in vivo perivenous induction by phenobarbital of cytochrome P-450 2B1 mRNA : role of epidermal_growth_factor and perivenous oxygen tension .
11229364	0	oxygen	141,147	epidermal_growth_factor	91,114	oxygen	epidermal growth factor	MESH:D010100	13645(Tax:10090)	Chemical	Gene	species|compound|START_ENTITY species|amod|END_ENTITY	Characterization of human and mouse peroxiredoxin_IV : evidence for inhibition by Prx-IV of epidermal_growth_factor - and p53-induced reactive oxygen species .
25338626	0	oxygen	9,15	epidermal_growth_factor_receptor	59,91	oxygen	epidermal growth factor receptor	MESH:D010100	13649(Tax:10090)	Chemical	Gene	species|compound|START_ENTITY species|dep|END_ENTITY	Reactive oxygen species - mediated activation of the Src - epidermal_growth_factor_receptor - Akt signaling cascade prevents bortezomib - induced apoptosis in hepatocellular_carcinoma cells .
24701552	0	oxygen	11,17	era	46,49	oxygen	era	MESH:D010100	26284	Chemical	Gene	therapy|compound|START_ENTITY therapy|dep|END_ENTITY	Hyperbaric oxygen therapy - can it be the new era in dentistry ?
10329047	0	oxygen	135,141	erythropoietin	29,43	oxygen	erythropoietin	MESH:D010100	2056	Chemical	Gene	Effects|dep|START_ENTITY Effects|nmod|END_ENTITY	Effects of recombinant human erythropoietin on the antitumor effect of cisplatin in SCID mice bearing human ovarian_cancer : A possible oxygen effect .
11305808	0	oxygen	35,41	erythropoietin	87,101	oxygen	erythropoietin	MESH:D010100	2056	Chemical	Gene	delivery|compound|START_ENTITY hematocrit|nmod|delivery hematocrit|nmod|brain brain|nmod|END_ENTITY	Optimal hematocrit for the maximum oxygen delivery to the brain with recombinant human erythropoietin in hemodialysis patients .
14551773	0	oxygen	7,13	erythropoietin	110,124	oxygen	erythropoietin	MESH:D010100	2056	Chemical	Gene	kinetics|compound|START_ENTITY exercise|nsubj|kinetics exercise|xcomp|following following|dobj|treatment treatment|compound|END_ENTITY	Faster oxygen uptake kinetics at the onset of submaximal cycling exercise following 4 weeks recombinant human erythropoietin -LRB- r-HuEPO -RRB- treatment .
16239610	0	oxygen	130,136	erythropoietin	6,20	oxygen	erythropoietin	MESH:D010100	2056	Chemical	Gene	paradox|compound|START_ENTITY levels|dep|paradox levels|compound|END_ENTITY	Serum erythropoietin levels in healthy humans after a short period of normobaric and hyperbaric oxygen breathing : the `` normobaric oxygen paradox '' .
16239610	0	oxygen	96,102	erythropoietin	6,20	oxygen	erythropoietin	MESH:D010100	2056	Chemical	Gene	breathing|compound|START_ENTITY period|nmod|breathing humans|nmod|period levels|nmod|humans levels|compound|END_ENTITY	Serum erythropoietin levels in healthy humans after a short period of normobaric and hyperbaric oxygen breathing : the `` normobaric oxygen paradox '' .
17362920	7	oxygen	1158,1164	erythropoietin	1131,1145	oxygen	erythropoietin	MESH:D010100	24335(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY END_ENTITY|nmod|levels	Furthermore , the effect of erythropoietin on reactive oxygen species levels was also blocked by LY_294002 .
17699326	0	oxygen	49,55	erythropoietin	82,96	oxygen	erythropoietin	MESH:D010100	2056	Chemical	Gene	sensor|compound|START_ENTITY sensor|nmod|release release|nmod|END_ENTITY	Properties permitting the renal cortex to be the oxygen sensor for the release of erythropoietin : clinical implications .
20821977	0	oxygen	35,41	erythropoietin	11,25	oxygen	erythropoietin	MESH:D010100	24335(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY Effect|nmod|transport Effect|nmod|END_ENTITY	-LSB- Effect of erythropoietin on blood oxygen transport in rats during cold exposure and subsequent rewarming -RSB- .
21294852	0	oxygen	137,143	erythropoietin	57,71	oxygen	erythropoietin	MESH:D010100	2056	Chemical	Gene	theory|compound|START_ENTITY evidence|nmod|theory concentration|dep|evidence concentration|compound|END_ENTITY	Acute normobaric hyperoxia transiently attenuates plasma erythropoietin concentration in healthy males : evidence against the ` normobaric oxygen paradox ' theory .
22222171	0	oxygen	47,53	erythropoietin	8,22	oxygen	erythropoietin	MESH:D010100	2056	Chemical	Gene	delivery|compound|START_ENTITY equations|dobj|delivery equations|nsubj|END_ENTITY	Towards erythropoietin equations that estimate oxygen delivery rather than static hemoglobin targets .
22672319	0	oxygen	48,54	erythropoietin	10,24	oxygen	erythropoietin	MESH:D010100	2056	Chemical	Gene	tension|compound|START_ENTITY increases|dobj|tension increases|nsubj|END_ENTITY	High dose erythropoietin increases brain tissue oxygen tension in severe vasospasm after subarachnoid_hemorrhage .
2632899	0	oxygen	112,118	erythropoietin	27,41	oxygen	erythropoietin	MESH:D010100	13856(Tax:10090)	Chemical	Gene	affinity|compound|START_ENTITY changes|nmod|affinity changes|nmod|level level|compound|END_ENTITY	Temporal changes of plasma erythropoietin level in hypobaric hypoxic mice and the influence of an altered blood oxygen affinity .
2849206	0	oxygen	57,63	erythropoietin	18,32	oxygen	erythropoietin	MESH:D010100	2056	Chemical	Gene	sensor|compound|START_ENTITY protein|nsubj|sensor evidence|dep|protein Regulation|dep|evidence Regulation|nmod|gene gene|compound|END_ENTITY	Regulation of the erythropoietin gene : evidence that the oxygen sensor is a heme protein .
3401235	0	oxygen	20,26	erythropoietin	42,56	oxygen	erythropoietin	MESH:D010100	2056	Chemical	Gene	Effects|nmod|START_ENTITY metabolites|nsubj|Effects metabolites|nmod|production production|compound|END_ENTITY	Effects of reactive oxygen metabolites on erythropoietin production in renal_carcinoma cells .
3501227	0	oxygen	3,9	erythropoietin	39,53	oxygen	erythropoietin	MESH:D010100	2056	Chemical	Gene	supply|compound|START_ENTITY regulator|nsubj|supply regulator|nmod|levels levels|compound|END_ENTITY	Is oxygen supply the only regulator of erythropoietin levels ?
3593309	0	oxygen	49,55	erythropoietin	14,28	oxygen	erythropoietin	MESH:D010100	24335(Tax:10116)	Chemical	Gene	affinity|compound|START_ENTITY Dependence|nmod|affinity Dependence|nmod|production production|compound|END_ENTITY	Dependence of erythropoietin production on blood oxygen affinity and hemoglobin concentration in rats .
6502313	0	oxygen	73,79	erythropoietin	44,58	oxygen	erythropoietin	MESH:D010100	2056	Chemical	Gene	immunoreactive|nmod|START_ENTITY immunoreactive|dobj|END_ENTITY	Decreased response of plasma immunoreactive erythropoietin to `` available oxygen '' in anemia of prematurity .
6738642	0	oxygen	11,17	erythropoietin	43,57	oxygen	erythropoietin	MESH:D010100	2056	Chemical	Gene	Effects|nmod|START_ENTITY inhalation|nsubj|Effects inhalation|nmod|kinetics kinetics|compound|END_ENTITY	Effects of oxygen inhalation on endogenous erythropoietin kinetics , erythropoiesis , and properties of blood cells in sickle-cell_anemia .
7757199	0	oxygen	75,81	erythropoietin	50,64	oxygen	erythropoietin	MESH:D010100	2056	Chemical	Gene	species|compound|START_ENTITY loss|nmod|species loss|nmod|activity activity|nmod|END_ENTITY	The loss of in vivo activity of recombinant human erythropoietin by active oxygen species .
8394533	0	oxygen	48,54	erythropoietin	81,95	oxygen	erythropoietin	MESH:D010100	2056	Chemical	Gene	START_ENTITY|acl|releasing releasing|nmod|treatment treatment|compound|END_ENTITY	Reduced oxygen affinity contributes to improved oxygen releasing capacity during erythropoietin treatment of renal_anaemia .
8394533	0	oxygen	8,14	erythropoietin	81,95	oxygen	erythropoietin	MESH:D010100	2056	Chemical	Gene	contributes|nsubj|START_ENTITY contributes|nmod|oxygen oxygen|acl|releasing releasing|nmod|treatment treatment|compound|END_ENTITY	Reduced oxygen affinity contributes to improved oxygen releasing capacity during erythropoietin treatment of renal_anaemia .
8660366	0	oxygen	101,107	erythropoietin	54,68	oxygen	erythropoietin	MESH:D010100	2056	Chemical	Gene	sensor|compound|START_ENTITY protein|nsubj|sensor evidence|dep|protein Effects|dep|evidence Effects|nmod|transition_metals transition_metals|nmod|expression expression|nmod|gene gene|compound|END_ENTITY	Effects of transition_metals on the expression of the erythropoietin gene : further evidence that the oxygen sensor is a heme protein .
9027714	0	oxygen	106,112	erythropoietin	29,43	oxygen	erythropoietin	MESH:D010100	13856(Tax:10090)	Chemical	Gene	affecting|dobj|START_ENTITY conditions|acl|affecting secretion|nmod|conditions secretion|compound|END_ENTITY	Unexpected hypoxia-dependent erythropoietin secretion during experimental conditions not affecting tissue oxygen supply/demand ratio .
9027728	0	oxygen	103,109	erythropoietin	65,79	oxygen	erythropoietin	MESH:D010100	2056	Chemical	Gene	species|compound|START_ENTITY antagonize|nmod|species antagonize|dobj|inhibition inhibition|nmod|production production|compound|END_ENTITY	Cobalt_chloride and desferrioxamine antagonize the inhibition of erythropoietin production by reactive oxygen species .
9049176	0	oxygen	57,63	erythropoietin	78,92	oxygen	erythropoietin	MESH:D010100	24335(Tax:10116)	Chemical	Gene	regulation|compound|START_ENTITY genes|nmod|regulation Lack|nmod|genes Lack|nmod|expression expression|compound|END_ENTITY	Lack of control by immediate early response genes in the oxygen regulation of erythropoietin gene expression .
9085366	0	oxygen	84,90	erythropoietin	69,83	oxygen	erythropoietin	MESH:D010100	13856(Tax:10090)	Chemical	Gene	sensor|compound|START_ENTITY sensor|compound|END_ENTITY	Products of red blood cell degradation inhibit responsiveness of the erythropoietin oxygen sensor .
9350435	0	oxygen	17,23	erythropoietin	91,105	oxygen	erythropoietin	MESH:D010100	2056	Chemical	Gene	radicals|compound|START_ENTITY Effect|nmod|radicals Effect|nmod|END_ENTITY	Effect of active oxygen radicals on protein and carbohydrate moieties of recombinant human erythropoietin .
9382954	0	oxygen	81,87	erythropoietin	49,63	oxygen	erythropoietin	MESH:D010100	13856(Tax:10090)	Chemical	Gene	tension|compound|START_ENTITY function|nmod|tension approach|nmod|function approach|nmod|delivery delivery|nmod|END_ENTITY	A gene therapy approach to regulated delivery of erythropoietin as a function of oxygen tension .
18941890	0	oxygen	9,15	estrogen_receptor_alpha	72,95	oxygen	estrogen receptor alpha	MESH:D010100	2099	Chemical	Gene	species|compound|START_ENTITY induce|nsubj|species induce|nmod|END_ENTITY	Reactive oxygen species induce phosphorylation of serine 118 and 167 on estrogen_receptor_alpha .
12695528	0	oxygen	74,80	extracellular_signal-regulated_kinase	16,53	oxygen	extracellular signal-regulated kinase	MESH:D010100	24338(Tax:10116)	Chemical	Gene	pathway|nmod|START_ENTITY pathway|amod|END_ENTITY	Crucial role of extracellular_signal-regulated_kinase pathway in reactive oxygen species-mediated endothelin-1 gene expression induced by endothelin-1 in rat cardiac fibroblasts .
14730203	0	oxygen	17,23	extracellular_signal-regulated_kinase	42,79	oxygen	extracellular signal-regulated kinase	MESH:D010100	5594	Chemical	Gene	Role|nmod|START_ENTITY species-sensitive|nsubj|Role species-sensitive|dobj|pathway pathway|amod|END_ENTITY	Role of reactive oxygen species-sensitive extracellular_signal-regulated_kinase pathway in angiotensin_II-induced endothelin-1 gene expression in vascular endothelial cells .
18398338	0	oxygen	9,15	extracellular_signal-regulated_kinase	106,143	oxygen	extracellular signal-regulated kinase	MESH:D010100	5594	Chemical	Gene	species|compound|START_ENTITY oxidized|nsubj|species oxidized|dobj|expression expression|nmod|END_ENTITY	Reactive oxygen species mediate oxidized low-density lipoprotein-induced endothelin-1 gene expression via extracellular_signal-regulated_kinase in vascular endothelial cells .
22249458	0	oxygen	68,74	extracellular_signal-regulated_kinase	107,144	oxygen	extracellular signal-regulated kinase	MESH:D010100	24338(Tax:10116)	Chemical	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Mutant presenilin_2 increases b-secretase activity through reactive oxygen species-dependent activation of extracellular_signal-regulated_kinase .
23433299	0	oxygen	90,96	extracellular_signal-regulated_kinase	127,164	oxygen	extracellular signal-regulated kinase	MESH:D010100	5594	Chemical	Gene	species|compound|START_ENTITY species|dep|involvement involvement|amod|END_ENTITY	Grape_seed_extract triggers apoptosis in Caco-2 human colon_cancer cells through reactive oxygen species and calcium increase : extracellular_signal-regulated_kinase involvement .
22526333	0	oxygen	23,29	fas_ligand	107,117	oxygen	fas ligand	MESH:D010100	356	Chemical	Gene	species|compound|START_ENTITY Production|nmod|species stem|nsubj|Production stem|advcl|END_ENTITY	Production of reactive oxygen species by multipotent stromal cells/mesenchymal stem cells upon exposure to fas_ligand .
15633612	0	oxygen	9,15	focal_adhesion_kinase	34,55	oxygen	focal adhesion kinase	MESH:D010100	14083(Tax:10090)	Chemical	Gene	species|compound|START_ENTITY increased|nsubj|species increased|dobj|production production|amod|END_ENTITY	Reactive oxygen species increased focal_adhesion_kinase production in pulmonary microvascular endothelial cells .
16040628	0	oxygen	23,29	focal_adhesion_kinase	96,117	oxygen	focal adhesion kinase	MESH:D010100	506270(Tax:9913)	Chemical	Gene	Regulation|nmod|START_ENTITY species-induced|nsubj|Regulation species-induced|nmod|proteins proteins|amod|END_ENTITY	Regulation of reactive oxygen species-induced endothelial cell-cell and cell-matrix contacts by focal_adhesion_kinase and adherens junction proteins .
21555563	0	oxygen	74,80	focal_adhesion_kinase	114,135	oxygen	focal adhesion kinase	MESH:D010100	5747	Chemical	Gene	inactivation|compound|START_ENTITY inactivation|nmod|phosphatases phosphatases|amod|END_ENTITY	Enteric commensal bacteria potentiate epithelial restitution via reactive oxygen species-mediated inactivation of focal_adhesion_kinase phosphatases .
20619709	0	oxygen	43,49	folate_receptor_1	61,78	oxygen	folate receptor 1	MESH:D010100	2348	Chemical	Gene	species|compound|START_ENTITY species|nmod|END_ENTITY	Effect of antiepileptic drugs and reactive oxygen species on folate_receptor_1 -LRB- FOLR1 -RRB- - dependent 5-methyltetrahydrofolate transport .
4663013	0	oxygen	78,84	growth_hormone	12,26	oxygen	growth hormone	MESH:D010100	81668(Tax:10116)	Chemical	Gene	consumption|compound|START_ENTITY END_ENTITY|nmod|consumption	-LSB- Effects of growth_hormone , norethandrolone and of a combination of the 2 , on oxygen consumption of liver homogenates in rats -RSB- .
25712221	0	oxygen	71,77	hIDO1	57,62	oxygen	hIDO1	MESH:D010100	3620	Chemical	Gene	activity|nmod|START_ENTITY activity|appos|END_ENTITY	Catalytic activity of human indoleamine 2,3-dioxygenase -LRB- hIDO1 -RRB- at low oxygen .
1201209	0	oxygen	4,10	haemoglobin_E	23,36	oxygen	haemoglobin E	MESH:D010100	3046	Chemical	Gene	affinity|compound|START_ENTITY affinity|nmod|END_ENTITY	The oxygen affinity of haemoglobin_E .
10465686	0	oxygen	128,134	heme_oxygenase-1	14,30	oxygen	heme oxygenase-1	MESH:D010100	24451(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY involvement|nmod|production Expression|dep|involvement Expression|nmod|END_ENTITY	Expression of heme_oxygenase-1 mediated by non-NMDA and metabotropic receptors in glial cells : possible involvement of reactive oxygen species production and protein kinase C activation .
11023535	0	oxygen	107,113	heme_oxygenase-1	13,29	oxygen	heme oxygenase-1	MESH:D010100	3162	Chemical	Gene	treatment|compound|START_ENTITY damage|nmod|treatment damage|nsubj|Induction Induction|nmod|protection protection|amod|END_ENTITY	Induction of heme_oxygenase-1 and adaptive protection against the induction of DNA damage after hyperbaric oxygen treatment .
11751428	0	oxygen	104,110	heme_oxygenase-1	15,31	oxygen	heme oxygenase-1	MESH:D010100	3162	Chemical	Gene	treatment|compound|START_ENTITY lymphocytes|nmod|treatment protection|nmod|lymphocytes Involvement|nmod|protection Involvement|nmod|END_ENTITY	Involvement of heme_oxygenase-1 -LRB- HO-1 -RRB- in the adaptive protection of human lymphocytes after hyperbaric oxygen -LRB- HBO -RRB- treatment .
12361808	0	oxygen	98,104	heme_oxygenase-1	133,149	oxygen	heme oxygenase-1	MESH:D010100	24451(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY scavenging|nmod|species scavenging|nmod|END_ENTITY	Paradoxical effects of metalloporphyrins on doxorubicin-induced apoptosis : scavenging of reactive oxygen species versus induction of heme_oxygenase-1 .
12489116	0	oxygen	101,107	heme_oxygenase-1	18,34	oxygen	heme oxygenase-1	MESH:D010100	3162	Chemical	Gene	resistance|nmod|START_ENTITY results|nmod|resistance results|nsubj|Overexpression Overexpression|nmod|HO-1 HO-1|amod|END_ENTITY	Overexpression of heme_oxygenase-1 -LRB- HO-1 -RRB- in V79 cells results in increased resistance to hyperbaric oxygen -LRB- HBO -RRB- - induced DNA damage .
15024026	0	oxygen	93,99	heme_oxygenase-1	46,62	oxygen	heme oxygenase-1	MESH:D010100	3162	Chemical	Gene	manner|compound|START_ENTITY expression|nmod|manner expression|amod|END_ENTITY	15-deoxy-delta_12 ,14 - prostaglandin_J2 induces heme_oxygenase-1 gene expression in a reactive oxygen species-dependent manner in human lymphocytes .
16146466	0	oxygen	11,17	heme_oxygenase-1	87,103	oxygen	heme oxygenase-1	MESH:D010100	24451(Tax:10116)	Chemical	Gene	attenuation|compound|START_ENTITY involves|nsubj|attenuation involves|xcomp|END_ENTITY	Hyperbaric oxygen attenuation of lipopolysaccharide-induced acute_lung_injury involves heme_oxygenase-1 .
16271489	0	oxygen	61,67	heme_oxygenase-1	14,30	oxygen	heme oxygenase-1	MESH:D010100	3162	Chemical	Gene	due|nmod|START_ENTITY species|amod|due species|amod|END_ENTITY	Expression of heme_oxygenase-1 due to intracellular reactive oxygen species induced by ultrasound .
16625420	0	oxygen	72,78	heme_oxygenase-1	35,51	oxygen	heme oxygenase-1	MESH:D010100	15368(Tax:10090)	Chemical	Gene	generation|compound|START_ENTITY reactive|dobj|generation reactive|nsubj|Carbon_monoxide Carbon_monoxide|nmod|suppresses suppresses|amod|END_ENTITY	Carbon_monoxide and bilirubin from heme_oxygenase-1 suppresses reactive oxygen species generation and plasminogen_activator_inhibitor-1 induction .
17140381	0	oxygen	122,128	heme_oxygenase-1	61,77	oxygen	heme oxygenase-1	MESH:D010100	3162	Chemical	Gene	species|compound|START_ENTITY Changes|nmod|species Changes|nmod|expression expression|nmod|genes genes|acl|encoding encoding|dobj|enzymes enzymes|amod|Bcl-2 Bcl-2|amod|END_ENTITY	Changes in expression of genes encoding antioxidant enzymes , heme_oxygenase-1 , Bcl-2 , and Bcl-xl and in level of reactive oxygen species in tumor cells resistant to doxorubicin .
17277740	0	oxygen	102,108	heme_oxygenase-1	17,33	oxygen	heme oxygenase-1	MESH:D010100	3162	Chemical	Gene	generation|compound|START_ENTITY mediated|nmod|generation expression|acl|mediated expression|amod|END_ENTITY	Vitreous induces heme_oxygenase-1 expression mediated by transforming_growth_factor-beta and reactive oxygen species generation in human retinal_pigment_epithelial cells .
17291539	0	oxygen	32,38	heme_oxygenase-1	110,126	oxygen	heme oxygenase-1	MESH:D010100	3162	Chemical	Gene	Preconditioning|nmod|START_ENTITY Preconditioning|nsubj|tolerance tolerance|nmod|injury injury|nmod|expression expression|nmod|neurons neurons|amod|END_ENTITY	Preconditioning with hyperbaric oxygen induces tolerance against oxidative injury via increased expression of heme_oxygenase-1 in primary cultured spinal cord neurons .
18242889	0	oxygen	133,139	heme_oxygenase-1	79,95	oxygen	heme oxygenase-1	MESH:D010100	15368(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Maternally administered lipopolysaccharide -LRB- LPS -RRB- upregulates the expression of heme_oxygenase-1 in fetal liver : the role of reactive oxygen species .
18845130	0	oxygen	9,15	heme_oxygenase-1	99,115	oxygen	heme oxygenase-1	MESH:D010100	3162	Chemical	Gene	apoptosis|compound|START_ENTITY apoptosis|dep|role role|nmod|down-modulation down-modulation|amod|END_ENTITY	Reactive oxygen species-independent apoptosis in doxorubicin-treated H9c2 cardiomyocytes : role for heme_oxygenase-1 down-modulation .
19476795	0	oxygen	17,23	heme_oxygenase-1	40,56	oxygen	heme oxygenase-1	MESH:D010100	24451(Tax:10116)	Chemical	Gene	carrier|compound|START_ENTITY induces|nsubj|carrier induces|xcomp|END_ENTITY	Hemoglobin-based oxygen carrier induces heme_oxygenase-1 in the heart and lung but not brain .
19833168	0	oxygen	73,79	heme_oxygenase-1	18,34	oxygen	heme oxygenase-1	MESH:D010100	3162	Chemical	Gene	species|amod|START_ENTITY up-regulation|nmod|species pathway|amod|up-regulation pathway|amod|END_ENTITY	Rottlerin induces heme_oxygenase-1 -LRB- HO-1 -RRB- up-regulation through reactive oxygen species -LRB- ROS -RRB- dependent and PKC_delta-independent pathway in human colon_cancer HT29 cells .
20942796	0	oxygen	81,87	heme_oxygenase-1	99,115	oxygen	heme oxygenase-1	MESH:D010100	24451(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY Inhibition|nmod|species Inhibition|nmod|microsomes microsomes|amod|END_ENTITY	Inhibition of cytochrome_P450_1A2-mediated metabolism and production of reactive oxygen species by heme_oxygenase-1 in rat liver microsomes .
21816440	0	oxygen	32,38	heme_oxygenase-1	127,143	oxygen	heme oxygenase-1	MESH:D010100	24451(Tax:10116)	Chemical	Gene	Preconditioning|nmod|START_ENTITY Preconditioning|nsubj|tolerance tolerance|nmod|renal_ischemia-reperfusion_injury renal_ischemia-reperfusion_injury|nmod|expression expression|nmod|END_ENTITY	Preconditioning with hyperbaric oxygen induces tolerance against renal_ischemia-reperfusion_injury via increased expression of heme_oxygenase-1 .
21890508	0	oxygen	54,60	heme_oxygenase-1	103,119	oxygen	heme oxygenase-1	MESH:D010100	24451(Tax:10116)	Chemical	Gene	diseases|compound|START_ENTITY hemin|nmod|diseases potential|nmod|hemin potential|nmod|induction induction|nmod|END_ENTITY	Therapeutic potential of pegylated hemin for reactive oxygen species-related diseases via induction of heme_oxygenase-1 : results from a rat hepatic ischemia/reperfusion injury model .
22019695	0	oxygen	9,15	heme_oxygenase-1	94,110	oxygen	heme oxygenase-1	MESH:D010100	3162	Chemical	Gene	species|compound|START_ENTITY play|nsubj|species play|nmod|induction induction|nmod|expression expression|amod|END_ENTITY	Reactive oxygen species and PI3K/Akt signaling play key roles in the induction of Nrf2-driven heme_oxygenase-1 expression in sulforaphane-treated human mesothelioma MSTO-211H cells .
22539869	0	oxygen	147,153	heme_oxygenase-1	93,109	oxygen	heme oxygenase-1	MESH:D010100	3162	Chemical	Gene	cells|nmod|START_ENTITY cells|nmod|stress stress|nmod|induction induction|nmod|expression expression|amod|END_ENTITY	Curcumin protects retinal pigment epithelial cells against oxidative stress via induction of heme_oxygenase-1 expression and reduction of reactive oxygen .
23425954	0	oxygen	55,61	heme_oxygenase-1	93,109	oxygen	heme oxygenase-1	MESH:D010100	15368(Tax:10090)	Chemical	Gene	species|compound|START_ENTITY NADPH|dobj|species NADPH|advcl|END_ENTITY	D5_dopamine_receptor decreases NADPH oxidase , reactive oxygen species and blood pressure via heme_oxygenase-1 .
24442713	0	oxygen	32,38	heme_oxygenase-1	119,135	oxygen	heme oxygenase-1	MESH:D010100	3162	Chemical	Gene	species|compound|START_ENTITY promote|nsubj|species promote|nmod|END_ENTITY	Angiotensin_II-derived reactive oxygen species promote angiogenesis in human late endothelial progenitor cells through heme_oxygenase-1 via ERK1/2 and AKT/PI3K pathways .
25150395	0	oxygen	64,70	heme_oxygenase-1	17,33	oxygen	heme oxygenase-1	MESH:D010100	3162	Chemical	Gene	level|compound|START_ENTITY reactive|dobj|level reactive|nsubj|Up-regulation Up-regulation|nmod|modulates modulates|amod|END_ENTITY	Up-regulation of heme_oxygenase-1 expression modulates reactive oxygen species level during the cryopreservation of human seminiferous tubules .
25264201	0	oxygen	11,17	heme_oxygenase-1	96,112	oxygen	heme oxygenase-1	MESH:D010100	24451(Tax:10116)	Chemical	Gene	preconditioning|compound|START_ENTITY protects|nsubj|preconditioning protects|nmod|rats rats|nmod|induction induction|amod|END_ENTITY	Hyperbaric oxygen preconditioning protects lung against hyperoxic acute_lung_injury in rats via heme_oxygenase-1 induction .
17143561	0	oxygen	65,71	heme_oxygenase_1	17,33	oxygen	heme oxygenase 1	MESH:D010100	3162	Chemical	Gene	species|compound|START_ENTITY generation|nmod|species induces|nmod|generation induces|dobj|END_ENTITY	Curcumin induces heme_oxygenase_1 through generation of reactive oxygen species , p38 activation and phosphatase inhibition .
17689698	0	oxygen	17,23	heme_oxygenase_1	48,64	oxygen	heme oxygenase 1	MESH:D010100	15368(Tax:10090)	Chemical	Gene	carrier|compound|START_ENTITY induces|nsubj|carrier induces|dobj|expression expression|amod|END_ENTITY	Hemoglobin-based oxygen carrier induces hepatic heme_oxygenase_1 expression in Kupffer cells .
18293159	0	oxygen	90,96	heme_oxygenase_1	20,36	oxygen	heme oxygenase 1	MESH:D010100	24451(Tax:10116)	Chemical	Gene	Oxyglobin|compound|START_ENTITY based|dobj|Oxyglobin hemoglobin|acl|based exposed|nmod|hemoglobin exposed|nsubj|Failed_induction Failed_induction|nmod|END_ENTITY	Failed_induction of heme_oxygenase_1 in endothelial cells exposed to the hemoglobin based oxygen carrier Oxyglobin .
23042187	0	oxygen	184,190	heme_oxygenase_1	209,225	oxygen	heme oxygenase 1	MESH:D010100	15368(Tax:10090)	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Prostaglandins as negative regulators against lipopolysaccharide , lipoteichoic_acid , and peptidoglycan-induced inducible nitric_oxide synthase/nitric _ oxide production through reactive oxygen species-dependent heme_oxygenase_1 expression in macrophages .
1494928	0	oxygen	140,146	hemoglobin	129,139	oxygen	hemoglobin	MESH:D010100	100323610(Tax:9823)	Chemical	Gene	saturation|compound|START_ENTITY saturation|compound|END_ENTITY	Correlated , simultaneous , multiple-wavelength optical monitoring in vivo of localized cerebrocortical NADH and brain microvessel hemoglobin oxygen saturation .
26040511	0	oxygen	88,94	high-mobility_group_box-1	27,52	oxygen	high-mobility group box-1	MESH:D010100	25459(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY species|amod|END_ENTITY	Mutual enhancement between high-mobility_group_box-1 and NADPH oxidase-derived reactive oxygen species mediates diabetes-induced upregulation of retinal apoptotic markers .
12087669	0	oxygen	61,67	hip	88,91	oxygen	hip	MESH:D010100	6159	Chemical	Gene	species|compound|START_ENTITY production|nmod|species production|nmod|END_ENTITY	-LSB- Polymorphonuclear leucocytes and the production of reactive oxygen species after total hip and knee replacement -RSB- .
16585195	0	oxygen	4,10	hypoxia-inducible_factor-1	36,62	oxygen	hypoxia-inducible factor-1	MESH:D010100	3091	Chemical	Gene	sensor|nsubj|START_ENTITY sensor|dobj|expression expression|amod|END_ENTITY	The oxygen sensor factor-inhibiting hypoxia-inducible_factor-1 controls expression of distinct genes through the bifunctional transcriptional character of hypoxia-inducible_factor-1alpha .
21059928	0	oxygen	32,38	hypoxia-inducible_factor-1	68,94	oxygen	hypoxia-inducible factor-1	MESH:D010100	3091	Chemical	Gene	production|compound|START_ENTITY activates|nsubj|production activates|dobj|HIF-1 HIF-1|amod|END_ENTITY	NADPH oxidase-mediated reactive oxygen species production activates hypoxia-inducible_factor-1 -LRB- HIF-1 -RRB- via the ERK pathway after hyperthermia treatment .
23268347	0	oxygen	138,144	hypoxia-inducible_factor-1	32,58	oxygen	hypoxia-inducible factor-1	MESH:D010100	180359(Tax:6239)	Chemical	Gene	conditions|compound|START_ENTITY changes|nmod|conditions adapted|nmod|changes nematode|acl|adapted Cloning|dep|nematode Cloning|nmod|subunits subunits|amod|END_ENTITY	Cloning and characterization of hypoxia-inducible_factor-1 subunits from Ascaris_suum - a parasitic nematode highly adapted to changes of oxygen conditions during its life cycle .
22349311	0	oxygen	23,29	hypoxia-inducible_factor-1a	64,91	oxygen	hypoxia-inducible factor-1a	MESH:D010100	3091	Chemical	Gene	species|compound|START_ENTITY mediates|nsubj|species mediates|dobj|expression expression|amod|END_ENTITY	Mitochondrial reactive oxygen species mediates nicotine-induced hypoxia-inducible_factor-1a expression in human non-small cell lung_cancer cells .
24157153	0	oxygen	11,17	hypoxia-inducible_factor-1a	48,75	oxygen	hypoxia-inducible factor-1a	MESH:D010100	29560(Tax:10116)	Chemical	Gene	intervention|compound|START_ENTITY intervention|nmod|END_ENTITY	Hyperbaric oxygen intervention on expression of hypoxia-inducible_factor-1a and vascular_endothelial_growth_factor in spinal_cord_injury models in rats .
24221993	0	oxygen	72,78	hypoxia-inducible_factor-1a	96,123	oxygen	hypoxia-inducible factor-1a	MESH:D010100	3091	Chemical	Gene	START_ENTITY|dep|activation activation|amod|END_ENTITY	Resveratrol suppresses cancer cell glucose uptake by targeting reactive oxygen species-mediated hypoxia-inducible_factor-1a activation .
12445170	0	oxygen	49,55	insulin	14,21	oxygen	insulin	MESH:D010100	3630	Chemical	Gene	consumption|compound|START_ENTITY effect|nmod|consumption effect|nmod|END_ENTITY	The effect of insulin and glucagon on splanchnic oxygen consumption .
15569593	0	oxygen	9,15	insulin	78,85	oxygen	insulin	MESH:D010100	3630	Chemical	Gene	species|compound|START_ENTITY induce|nsubj|species induce|nmod|END_ENTITY	Reactive oxygen species -LRB- ROS -RRB- induce chemical and structural changes on human insulin in vitro , including alterations in its immunoreactivity .
15998257	0	oxygen	33,39	insulin	55,62	oxygen	insulin	MESH:D010100	3630	Chemical	Gene	species|compound|START_ENTITY species|nmod|END_ENTITY	Role of insulin-induced reactive oxygen species in the insulin signaling pathway .
3544650	0	oxygen	11,17	insulin	134,141	oxygen	insulin	MESH:D010100	483665(Tax:9615)	Chemical	Gene	START_ENTITY|nmod|doses doses|nmod|END_ENTITY	Total body oxygen consumption and haemodynamics during the treatment of acute ischaemic heart_failure with dopamine and high doses of insulin in dogs .
9350418	0	oxygen	55,61	intercellular_adhesion_molecule-1	77,110	oxygen	intercellular adhesion molecule-1	MESH:D010100	3383	Chemical	Gene	intermediates|compound|START_ENTITY generation|nmod|intermediates Ionizing|dep|generation Ionizing|dep|END_ENTITY	Ionizing radiation induces , via generation of reactive oxygen intermediates , intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- gene transcription and NF_kappa_B-like binding activity in the ICAM-1 transcriptional regulatory region .
9437207	0	oxygen	9,15	intercellular_adhesion_molecule-1	61,94	oxygen	intercellular adhesion molecule-1	MESH:D010100	3383	Chemical	Gene	species|compound|START_ENTITY involved|nsubjpass|species involved|nmod|expression expression|amod|END_ENTITY	Reactive oxygen species are involved in shear stress-induced intercellular_adhesion_molecule-1 expression in endothelial cells .
9451527	0	oxygen	21,27	intercellular_adhesion_molecule-1	31,64	oxygen	intercellular adhesion molecule-1	MESH:D010100	15894(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of hyperbaric oxygen on intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression in murine lung .
8514243	0	oxygen	48,54	interleukin-1_beta	19,37	oxygen	interleukin-1 beta	MESH:D010100	24494(Tax:10116)	Chemical	Gene	consumption|dep|START_ENTITY consumption|amod|END_ENTITY	Chronic effects of interleukin-1_beta on fever , oxygen consumption and food intake in the rat .
10022882	0	oxygen	9,15	interleukin-1beta	63,80	oxygen	interleukin-1beta	MESH:D010100	3553	Chemical	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Reactive oxygen intermediate-dependent NF-kappaB activation by interleukin-1beta requires 5-lipoxygenase or NADPH oxidase activity .
11860476	0	oxygen	45,51	interleukin-1beta	14,31	oxygen	interleukin-1beta	MESH:D010100	24494(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY production|amod|END_ENTITY	Evidence that interleukin-1beta and reactive oxygen species production play a pivotal role in stress-induced impairment of LTP in the rat dentate gyrus .
12127835	0	oxygen	23,29	interleukin-1beta	41,58	oxygen	interleukin-1beta	MESH:D010100	3553	Chemical	Gene	species|compound|START_ENTITY Regulation|nmod|species Regulation|nmod|production production|amod|END_ENTITY	Regulation by reactive oxygen species of interleukin-1beta , nitric_oxide and prostaglandin_E -LRB- 2 -RRB- production by human chondrocytes .
12462562	0	oxygen	26,32	interleukin-1beta	116,133	oxygen	interleukin-1beta	MESH:D010100	100008990(Tax:9986)	Chemical	Gene	relation|compound|START_ENTITY correct|dobj|relation correct|nmod|vasomotor_shock vasomotor_shock|acl|induced induced|advcl|END_ENTITY	Dopamine does not correct oxygen consumption/oxygen delivery relation abnormality during vasomotor_shock induced by interleukin-1beta .
2553311	0	oxygen	171,177	interleukin_1	144,157	oxygen	interleukin 1	MESH:D010100	3552	Chemical	Gene	species|compound|START_ENTITY species|amod|END_ENTITY	Production of interleukin_1-like factor from human peripheral blood monocytes and polymorphonuclear leukocytes by superoxide anion : the role of interleukin_1 and reactive oxygen species in inflamed sites .
15885101	0	oxygen	13,19	lipoxygenase	27,39	oxygen	lipoxygenase	MESH:D010100	100009114(Tax:9986)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|reactions reactions|amod|END_ENTITY	Dual role of oxygen during lipoxygenase reactions .
17227895	0	oxygen	95,101	lipoxygenase	63,75	oxygen	lipoxygenase	MESH:D010100	547836(Tax:3847)	Chemical	Gene	content|compound|START_ENTITY rearrangement|nmod|content rearrangement|nmod|reactions reactions|amod|END_ENTITY	Intramolecular rearrangement of linolenate peroxyl radicals in lipoxygenase reactions at lower oxygen content .
18597258	0	oxygen	29,35	lipoxygenase	49,61	oxygen	lipoxygenase	MESH:D010100	547836(Tax:3847)	Chemical	Gene	measurement|nmod|START_ENTITY uptake|nsubj|measurement uptake|xcomp|using using|dobj|END_ENTITY	Polarographic measurement of oxygen uptake using lipoxygenase in reverse micelles .
3080416	0	oxygen	8,14	lipoxygenase	37,49	oxygen	lipoxygenase	MESH:D010100	547836(Tax:3847)	Chemical	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Singlet oxygen production by soybean lipoxygenase isozymes .
3924036	0	oxygen	53,59	lipoxygenase	13,25	oxygen	lipoxygenase	MESH:D010100	100009114(Tax:9986)	Chemical	Gene	uptake|compound|START_ENTITY share|nmod|uptake share|nmod|END_ENTITY	The share of lipoxygenase in the antimycin-resistant oxygen uptake of intact rabbit reticulocytes .
25736529	0	oxygen	103,109	mGluR5	0,6	oxygen	mGluR5	MESH:D010100	14805(Tax:10090)	Chemical	Gene	species|compound|START_ENTITY regulates|nmod|species regulates|nsubj|END_ENTITY	mGluR5 in the nucleus accumbens shell regulates morphine-associated contextual memory through reactive oxygen species signaling .
16847060	0	oxygen	73,79	mammalian_target_of_rapamycin	4,33	oxygen	mammalian target of rapamycin	MESH:D010100	2475	Chemical	Gene	consumption|compound|START_ENTITY regulates|dobj|consumption regulates|nsubj|END_ENTITY	The mammalian_target_of_rapamycin -LRB- mTOR -RRB- pathway regulates mitochondrial oxygen consumption and oxidative capacity .
15557194	0	oxygen	94,100	matrix_metalloproteinase-9	27,53	oxygen	matrix metalloproteinase-9	MESH:D010100	17395(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Lipopolysaccharide induces matrix_metalloproteinase-9 expression via a mitochondrial reactive oxygen species-p38 kinase-activator protein-1 pathway in Raw 264.7 cells .
19812919	0	oxygen	125,131	matrix_metalloproteinase-9	8,34	oxygen	matrix metalloproteinase-9	MESH:D010100	81687(Tax:10116)	Chemical	Gene	preconditioned|nmod|START_ENTITY preconditioned|nsubj|activity activity|amod|END_ENTITY	Reduced matrix_metalloproteinase-9 activity and cell death after global ischemia in the brain preconditioned with hyperbaric oxygen .
22507553	0	oxygen	95,101	matrix_metalloproteinase-9	32,58	oxygen	matrix metalloproteinase-9	MESH:D010100	4318	Chemical	Gene	astrocytes|nmod|START_ENTITY END_ENTITY|nmod|astrocytes	Albumin induces upregulation of matrix_metalloproteinase-9 in astrocytes via MAPK and reactive oxygen species-dependent pathways .
27049289	0	oxygen	98,104	matrix_metalloproteinase-9	58,84	oxygen	matrix metalloproteinase-9	MESH:D010100	4318	Chemical	Gene	species|compound|START_ENTITY species|amod|END_ENTITY	The effect of phosphatidylinositol-3 kinase inhibition on matrix_metalloproteinase-9 and reactive oxygen species release from chronic_obstructive_pulmonary_disease neutrophils .
24649711	0	oxygen	22,28	matrix_metalloproteinase_9	61,87	oxygen	matrix metalloproteinase 9	MESH:D010100	81687(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of hyperbaric oxygen on the expression of endogenous matrix_metalloproteinase_9 in rat lung tissue .
8007764	0	oxygen	45,51	metallothionein_I	10,27	oxygen	metallothionein I	MESH:D010100	24567(Tax:10116)	Chemical	Gene	consumption|compound|START_ENTITY Effect|nmod|consumption Effect|nmod|END_ENTITY	Effect of metallothionein_I on mitochondrial oxygen consumption .
6301495	0	oxygen	28,34	methemoglobin	64,77	oxygen	methemoglobin	MESH:D010100	3048	Chemical	Gene	species|compound|START_ENTITY production|nmod|species production|nmod|END_ENTITY	The production of activated oxygen species by an interaction of methemoglobin with ascorbate .
24378438	0	oxygen	73,79	miR-27b	106,113	oxygen	miR-27b	MESH:D010100	407019	Chemical	Gene	species|compound|START_ENTITY species|nmod|expression expression|amod|END_ENTITY	-LRB- 6 -RRB- - Gingerolinduced myeloid_leukemia cell death is initiated by reactive oxygen species and activation of miR-27b expression .
14755345	0	oxygen	66,72	mitochondrial_aldehyde_dehydrogenase	16,52	oxygen	mitochondrial aldehyde dehydrogenase	MESH:D010100	29539(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY species|amod|END_ENTITY	Central role of mitochondrial_aldehyde_dehydrogenase and reactive oxygen species in nitroglycerin tolerance and cross-tolerance .
9367876	0	oxygen	43,49	monocyte_chemotactic_protein-4	4,34	oxygen	monocyte chemotactic protein-4	MESH:D010100	6357	Chemical	Gene	production|compound|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	The monocyte_chemotactic_protein-4 induces oxygen radical production , actin reorganization , and CD11b up-regulation via a pertussis toxin-sensitive G-protein in human eosinophils .
11996112	0	oxygen	49,55	myeloperoxidase	76,91	oxygen	myeloperoxidase	MESH:D010100	4353	Chemical	Gene	species|compound|START_ENTITY species|acl|produced produced|nmod|END_ENTITY	The reactions of hypochlorous_acid , the reactive oxygen species produced by myeloperoxidase , with lipids .
14613914	0	oxygen	78,84	myeloperoxidase	15,30	oxygen	myeloperoxidase	MESH:D010100	4353	Chemical	Gene	species|compound|START_ENTITY species|amod|END_ENTITY	Interaction of myeloperoxidase with vascular NAD -LRB- P -RRB- H oxidase-derived reactive oxygen species in vasculature : implications for vascular_diseases .
15130787	0	oxygen	12,18	myeloperoxidase	38,53	oxygen	myeloperoxidase	MESH:D010100	4353	Chemical	Gene	Kinetics|nmod|START_ENTITY END_ENTITY|nsubj|Kinetics	Kinetics of oxygen binding to ferrous myeloperoxidase .
15350145	0	oxygen	32,38	myeloperoxidase	112,127	oxygen	myeloperoxidase	MESH:D010100	4353	Chemical	Gene	mechanism|nmod|START_ENTITY mechanism|dep|analysis analysis|nmod|formation formation|compound|END_ENTITY	A novel multistep mechanism for oxygen binding to ferrous hemoproteins : rapid kinetic analysis of ferrous-dioxy myeloperoxidase -LRB- compound III -RRB- formation .
15504976	0	oxygen	182,188	myeloperoxidase	18,33	oxygen	myeloperoxidase	MESH:D010100	303413(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY amplifies|nmod|species amplifies|compound|END_ENTITY	Leukocyte-derived myeloperoxidase amplifies high-glucose -- induced endothelial_dysfunction through interaction with high-glucose -- stimulated , vascular non -- leukocyte-derived reactive oxygen species .
17214642	0	oxygen	53,59	myeloperoxidase	83,98	oxygen	myeloperoxidase	MESH:D010100	4353	Chemical	Gene	species|compound|START_ENTITY species|nmod|END_ENTITY	Areca nut extracts reduce the intracellular reactive oxygen species and release of myeloperoxidase by human polymorphonuclear leukocytes .
18273043	0	oxygen	113,119	myeloperoxidase	14,29	oxygen	myeloperoxidase	MESH:D010100	4353	Chemical	Gene	species|compound|START_ENTITY generation|nmod|species enhances|nmod|generation enhances|nsubj|Expression Expression|nmod|END_ENTITY	Expression of myeloperoxidase enhances the chemosensitivity of leukemia cells through the generation of reactive oxygen species and the nitration of protein .
2991014	0	oxygen	53,59	myeloperoxidase	78,93	oxygen	myeloperoxidase	MESH:D010100	4353	Chemical	Gene	production|nmod|START_ENTITY ascorbic_acid|nmod|production ascorbic_acid|nmod|END_ENTITY	Effect of ascorbic_acid on the production of singlet oxygen by purified human myeloperoxidase .
3021423	0	oxygen	33,39	myeloperoxidase	53,68	oxygen	myeloperoxidase	MESH:D010100	4353	Chemical	Gene	forms|nmod|START_ENTITY Inactivation|nmod|forms generated|nsubj|Inactivation generated|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Inactivation of active forms of oxygen generated by myeloperoxidase and serum proteins -RSB- .
6090506	0	oxygen	37,43	myeloperoxidase	73,88	oxygen	myeloperoxidase	MESH:D010100	4353	Chemical	Gene	production|compound|START_ENTITY requirements|nmod|production requirements|nmod|END_ENTITY	Biochemical requirements for singlet oxygen production by purified human myeloperoxidase .
10360958	0	oxygen	115,121	myoglobin	54,63	oxygen	myoglobin	MESH:D010100	4151	Chemical	Gene	donors|compound|START_ENTITY mutants|nmod|donors mutants|nsubj|Assignment Assignment|nmod|ligand ligand|nmod|END_ENTITY	Assignment of the heme axial ligand -LRB- s -RRB- for the ferric myoglobin -LRB- H93G -RRB- and heme oxygenase -LRB- H25A -RRB- cavity mutants as oxygen donors using magnetic circular dichroism .
1055374	0	oxygen	12,18	myoglobin	75,84	oxygen	myoglobin	MESH:D010100	4151	Chemical	Gene	Kinetics|nmod|START_ENTITY Kinetics|amod|binding binding|nmod|analogs analogs|nmod|END_ENTITY	Kinetics of oxygen and carbon_monoxide binding to synthetic analogs of the myoglobin and hemoglobin active sites .
1150657	0	oxygen	12,18	myoglobin	31,40	oxygen	myoglobin	MESH:D010100	100054434(Tax:9796)	Chemical	Gene	affinity|compound|START_ENTITY affinity|nmod|END_ENTITY	Decrease in oxygen affinity of myoglobin by formylation of vinyl groups of heme .
11916512	0	oxygen	60,66	myoglobin	25,34	oxygen	myoglobin	MESH:D010100	4151	Chemical	Gene	transport|nmod|START_ENTITY facilitated|dobj|transport facilitated|nsubj|modeling modeling|nmod|END_ENTITY	Mathematical modeling of myoglobin facilitated transport of oxygen in devices containing myoglobin-expressing cells .
12236710	0	oxygen	74,80	myoglobin	5,14	oxygen	myoglobin	MESH:D010100	4151	Chemical	Gene	shows|dobj|START_ENTITY shows|nsubj|END_ENTITY	Blue myoglobin reconstituted with an iron porphycene shows extremely high oxygen affinity .
12530625	0	oxygen	35,41	myoglobin	12,21	oxygen	myoglobin	MESH:D010100	59108(Tax:10116)	Chemical	Gene	depletion|compound|START_ENTITY retarding|dobj|depletion END_ENTITY|acl|retarding	The role of myoglobin in retarding oxygen depletion in anoxic heart .
1420896	0	oxygen	87,93	myoglobin	64,73	oxygen	myoglobin	MESH:D010100	4151	Chemical	Gene	plays|nmod|START_ENTITY plays|dobj|role role|nmod|reaction reaction|nmod|END_ENTITY	Hydrogen_peroxide plays a key role in the oxidation reaction of myoglobin by molecular oxygen .
15050527	0	oxygen	15,21	myoglobin	165,174	oxygen	myoglobin	MESH:D010100	100054434(Tax:9796)	Chemical	Gene	binding|compound|START_ENTITY END_ENTITY|nsubj|binding	Unusually weak oxygen binding , physical properties , partial sequence , autoxidation rate and a potential phosphorylation site of beluga whale -LRB- Delphinapterus leucas -RRB- myoglobin .
16430787	0	oxygen	35,41	myoglobin	25,34	oxygen	myoglobin	MESH:D010100	59108(Tax:10116)	Chemical	Gene	saturation|compound|START_ENTITY saturation|amod|END_ENTITY	Virtual cooperativity in myoglobin oxygen saturation curve in skeletal muscle in vivo .
17218454	0	oxygen	106,112	myoglobin	41,50	oxygen	myoglobin	MESH:D010100	59108(Tax:10116)	Chemical	Gene	architecture|compound|START_ENTITY implication|nmod|architecture dependence|dep|implication dependence|nmod|diffusion diffusion|amod|END_ENTITY	Anisotropy and temperature dependence of myoglobin translational diffusion in myocardium : implication for oxygen transport and cellular architecture .
17607	1	oxygen	121,127	myoglobin	73,82	oxygen	myoglobin	MESH:D010100	102975021	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of sperm_whale myoglobin and Glycera hemoglobin with molecular oxygen .
17910795	0	oxygen	19,25	myoglobin	9,18	oxygen	myoglobin	MESH:D010100	59108(Tax:10116)	Chemical	Gene	saturation|compound|START_ENTITY saturation|compound|END_ENTITY	Accurate myoglobin oxygen saturation by optical spectroscopy measured in blood-perfused rat muscle .
18964710	0	oxygen	51,57	myoglobin	25,34	oxygen	myoglobin	MESH:D010100	4151	Chemical	Gene	transport|compound|START_ENTITY facilitating|dobj|transport END_ENTITY|acl|facilitating	Evidence for the role of myoglobin in facilitating oxygen transport .
20124401	0	oxygen	32,38	myoglobin	16,25	oxygen	myoglobin	MESH:D010100	4151	Chemical	Gene	store|compound|START_ENTITY END_ENTITY|nmod|store	Significance of myoglobin as an oxygen store and oxygen transporter in the intermittently perfused human heart : a model study .
20392104	0	oxygen	31,37	myoglobin	50,59	oxygen	myoglobin	MESH:D010100	4151	Chemical	Gene	affinity|compound|START_ENTITY modification|nmod|affinity Effect|nmod|modification Effect|nmod|END_ENTITY	Effect of heme modification on oxygen affinity of myoglobin and equilibrium of the acid-alkaline transition in metmyoglobin .
2229044	0	oxygen	56,62	myoglobin	83,92	oxygen	myoglobin	MESH:D010100	102975021	Chemical	Gene	reaction|compound|START_ENTITY reaction|nmod|END_ENTITY	Thermodynamic study of protein dynamic structure in the oxygen binding reaction of myoglobin .
23082875	0	oxygen	21,27	myoglobin	57,66	oxygen	myoglobin	MESH:D010100	4151	Chemical	Gene	affinity|compound|START_ENTITY Relationship|nmod|affinity Relationship|nmod|END_ENTITY	Relationship between oxygen affinity and autoxidation of myoglobin .
23297402	0	oxygen	26,32	myoglobin	43,52	oxygen	myoglobin	MESH:D010100	4151	Chemical	Gene	uptake|compound|START_ENTITY drives|dobj|uptake drives|nmod|END_ENTITY	Hydrophobic effect drives oxygen uptake in myoglobin via histidine E7 .
24552592	0	oxygen	24,30	myoglobin	86,95	oxygen	myoglobin	MESH:D010100	4151	Chemical	Gene	luminescence|nsubj|START_ENTITY luminescence|nmod|matrix matrix|nmod|END_ENTITY	Photosensitized singlet oxygen luminescence from the protein matrix of Zn-substituted myoglobin .
24866933	0	oxygen	98,104	myoglobin	14,23	oxygen	myoglobin	MESH:D010100	4151	Chemical	Gene	carrier|compound|START_ENTITY designing|dobj|carrier containing|advcl|designing Usefulness|acl|containing Usefulness|nmod|END_ENTITY	Usefulness of myoglobin containing cobalt heme cofactor in designing a myoglobin-based artificial oxygen carrier .
25280951	0	oxygen	147,153	myoglobin	57,66	oxygen	myoglobin	MESH:D010100	280695(Tax:9913)	Chemical	Gene	species|compound|START_ENTITY suppression|nmod|species END_ENTITY|nmod|suppression	In vitro heme and non-heme_iron capture from hemoglobin , myoglobin and ferritin by bovine_lactoferrin and implications for suppression of reactive oxygen species in vivo .
3103560	0	oxygen	21,27	myoglobin	48,57	oxygen	myoglobin	MESH:D010100	59108(Tax:10116)	Chemical	Gene	level|compound|START_ENTITY level|nmod|END_ENTITY	Nifedipine increases oxygen saturation level of myoglobin in the rat heart during hypoxia .
3559469	0	oxygen	80,86	myoglobin	14,23	oxygen	myoglobin	MESH:D010100	4151	Chemical	Gene	demand|compound|START_ENTITY levels|nmod|demand support|nmod|levels support|nsubj|Evidence Evidence|dep|END_ENTITY	Evidence that myoglobin does not support heart performance at maximal levels of oxygen demand .
3789196	0	oxygen	25,31	myoglobin	12,21	oxygen	myoglobin	MESH:D010100	4151	Chemical	Gene	consumption|compound|START_ENTITY Function|nmod|consumption Function|nmod|END_ENTITY	Function of myoglobin in oxygen consumption by isolated perfused fish hearts .
3812771	0	oxygen	56,62	myoglobin	5,14	oxygen	myoglobin	MESH:D010100	4151	Chemical	Gene	diffusion|nmod|START_ENTITY contribute|nmod|diffusion contribute|nsubj|END_ENTITY	Does myoglobin contribute significantly to diffusion of oxygen in red skeletal muscle ?
7634074	0	oxygen	126,132	myoglobin	73,82	oxygen	myoglobin	MESH:D010100	4151	Chemical	Gene	Myoglobin|nmod|START_ENTITY crystals|dep|Myoglobin crystals|nmod|END_ENTITY	Photolysis-induced structural changes in single crystals of carbonmonoxy myoglobin at 40 K. Myoglobin 's reversible binding of oxygen is a model for studies of protein control of ligand binding and discrimination .
7964404	6	oxygen	1227,1233	myoglobin	1163,1172	oxygen	Myoglobin	MESH:D010100	59108(Tax:10116)	Chemical	Gene	capacity|compound|START_ENTITY have|dobj|capacity demonstrate|ccomp|have demonstrate|nsubj|data data|compound|END_ENTITY	The myoglobin data demonstrate that the grey_seals have the highest oxygen storage capacity of the three pinniped species , which correlates with their greater diving ability .
8343616	0	oxygen	35,41	myoglobin	12,21	oxygen	myoglobin	MESH:D010100	4151	Chemical	Gene	depletion|compound|START_ENTITY retarding|dobj|depletion END_ENTITY|acl|retarding	The role of myoglobin in retarding oxygen depletion in skeletal muscle .
861221	0	oxygen	16,22	myoglobin	96,105	oxygen	myoglobin	MESH:D010100	4151	Chemical	Gene	indicator|compound|START_ENTITY Myoglobin|nmod|indicator Myoglobin|dep|characteristics characteristics|nmod|derivative derivative|compound|END_ENTITY	Myoglobin as an oxygen indicator for measuring the oxygen binding characteristics of a modified myoglobin derivative containing covalently bound mesoheme .
861221	0	oxygen	51,57	myoglobin	96,105	oxygen	myoglobin	MESH:D010100	4151	Chemical	Gene	measuring|dobj|START_ENTITY indicator|acl|measuring Myoglobin|nmod|indicator Myoglobin|dep|characteristics characteristics|nmod|derivative derivative|compound|END_ENTITY	Myoglobin as an oxygen indicator for measuring the oxygen binding characteristics of a modified myoglobin derivative containing covalently bound mesoheme .
8660313	0	oxygen	69,75	myoglobin	17,26	oxygen	myoglobin	MESH:D010100	102975021	Chemical	Gene	stabilization|compound|START_ENTITY mechanism|nmod|stabilization cloning|dep|mechanism cloning|amod|END_ENTITY	Aplysia limacina myoglobin cDNA cloning : an alternative mechanism of oxygen stabilization as studied by active-site mutagenesis .
9297300	0	oxygen	32,38	myoglobin	9,18	oxygen	myoglobin	MESH:D010100	4151	Chemical	Gene	supplying|dobj|START_ENTITY END_ENTITY|acl|supplying	-LSB- Role of myoglobin in supplying oxygen to tissues -RSB- .
9491255	0	oxygen	15,21	myoglobin	47,56	oxygen	myoglobin	MESH:D010100	4151	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of 100 % oxygen on EKG changes and serum myoglobin in fighter pilots .
9510524	0	oxygen	14,20	myoglobin	45,54	oxygen	myoglobin	MESH:D010100	4151	Chemical	Gene	diffusion|compound|START_ENTITY diffusion|dep|roles roles|nmod|END_ENTITY	Intracellular oxygen diffusion : the roles of myoglobin and lipid at cold body temperature .
9889895	0	oxygen	19,25	myoglobin	42,51	oxygen	myoglobin	MESH:D010100	418056(Tax:9031)	Chemical	Gene	protein|compound|START_ENTITY Involvement|nmod|protein END_ENTITY|nsubj|Involvement	Involvement of the oxygen storage protein myoglobin in muscle damage under oxidative stress .
10220589	0	oxygen	23,29	nerve_growth_factor	41,60	oxygen	nerve growth factor	MESH:D010100	310738(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY species|nmod|END_ENTITY	Regulation of reactive oxygen species by nerve_growth_factor but not Bcl-2 as a novel mechanism of protection of PC12 cells from superoxide anion-induced death .
25029423	0	oxygen	125,131	neuronal_pentraxin-1	91,111	oxygen	neuronal pentraxin-1	MESH:D010100	4884	Chemical	Gene	species|compound|START_ENTITY species|amod|END_ENTITY	Long-acting progestin-only contraceptives enhance human endometrial stromal cell expressed neuronal_pentraxin-1 and reactive oxygen species to promote endothelial cell apoptosis .
25462067	0	oxygen	100,106	nod-like_receptor_3	129,148	oxygen	nod-like receptor 3	MESH:D010100	114548	Chemical	Gene	species|compound|START_ENTITY species|dep|END_ENTITY	Defective mitophagy driven by dysregulation of rheb and KIF5B contributes to mitochondrial reactive oxygen species -LRB- ROS -RRB- - induced nod-like_receptor_3 -LRB- NLRP3 -RRB- dependent proinflammatory response and aggravates lipotoxicity .
26218693	0	oxygen	137,143	nuclear_factor_kB	162,179	oxygen	nuclear factor kB	MESH:D010100	309165(Tax:10116)	Chemical	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	The therapeutic effect and mechanism of niacin on acute_lung_injury in a rat model of hemorrhagic_shock : Down-regulation of the reactive oxygen species-dependent nuclear_factor_kB pathway .
17665043	0	oxygen	44,50	nuclear_factor_kappa_B	8,30	oxygen	nuclear factor kappa B	MESH:D010100	4790	Chemical	Gene	species|compound|START_ENTITY species|amod|END_ENTITY	Role of nuclear_factor_kappa_B and reactive oxygen species in the tumor_necrosis_factor-alpha-induced epithelial-mesenchymal_transition of MCF-7 cells .
1846307	0	oxygen	28,34	ornithine_decarboxylase	75,98	oxygen	ornithine decarboxylase	MESH:D010100	4953	Chemical	Gene	species|compound|START_ENTITY Role|nmod|species Role|nmod|END_ENTITY	Role of asbestos and active oxygen species in activation and expression of ornithine_decarboxylase in hamster_tracheal_epithelial cells .
19272631	0	oxygen	119,125	p-nitrophenol	89,102	oxygen	p-nitrophenol	MESH:D010100	4860	Chemical	Gene	using|dobj|START_ENTITY END_ENTITY|acl|using	Concurrent destruction strategy : NaNO2-catalyzed , trichlorophenol-coupled degradation of p-nitrophenol using molecular oxygen .
19366603	0	oxygen	59,65	p13	92,95	oxygen	p13	MESH:D010100	440926	Chemical	Gene	START_ENTITY|nmod|protein protein|amod|END_ENTITY	Modulation of mitochondrial K -LRB- + -RRB- permeability and reactive oxygen species production by the p13 protein of human_T-cell_leukemia_virus_type_1 .
20160708	0	oxygen	34,40	p21	17,20	oxygen	p21	MESH:D010100	1026	Chemical	Gene	production|compound|START_ENTITY production|amod|END_ENTITY	Feedback between p21 and reactive oxygen production is necessary for cell senescence .
8943236	0	oxygen	38,44	p21	13,16	oxygen	p21	MESH:D010100	1026	Chemical	Gene	species|compound|START_ENTITY mediated|nmod|species END_ENTITY|acl|mediated	Induction of p21 mediated by reactive oxygen species formed during the metabolism of aziridinylbenzoquinones by HCT116 cells .
10764657	0	oxygen	139,145	p22phox	118,125	oxygen	p22phox	MESH:D010100	79129(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY species|amod|END_ENTITY	Differential activation of mitogen-activated protein kinases in smooth muscle cells by angiotensin_II : involvement of p22phox and reactive oxygen species .
15994299	0	oxygen	115,121	p22phox	46,53	oxygen	p22phox	MESH:D010100	1535	Chemical	Gene	generation|compound|START_ENTITY inhibitors|nmod|generation inhibitors|nsubj|mutations mutations|nmod|region region|nmod|END_ENTITY	Point mutations in the proline-rich region of p22phox are dominant inhibitors of Nox1 - and Nox2-dependent reactive oxygen generation .
15994299	7	oxygen	1287,1293	p22phox	1237,1244	oxygen	p22phox	MESH:D010100	1535	Chemical	Gene	generation|compound|START_ENTITY disrupted|dobj|generation END_ENTITY|acl:relcl|disrupted	Truncated forms of p22phox that disrupted the PRR-inhibited reactive oxygen generation from Nox1 , Nox2 , and Nox3 but not from Nox4 and Nox5 .
18813787	0	oxygen	35,41	p28GANK	0,7	oxygen	p28GANK	MESH:D010100	5716	Chemical	Gene	species|compound|START_ENTITY species|amod|END_ENTITY	p28GANK knockdown-derived reactive oxygen species induces apoptosis through mitochondrial_dysfunction mediated by p38 in HepG2 cells .
20068565	0	oxygen	17,23	p38-mitogen-activated_protein_kinase	54,90	oxygen	p38-mitogen-activated protein kinase	MESH:D010100	1432	Chemical	Gene	species|compound|START_ENTITY Role|nmod|species Role|nmod|END_ENTITY	Role of reactive oxygen species in brucein_D-mediated p38-mitogen-activated_protein_kinase and nuclear factor-kappaB signalling pathways in human pancreatic_adenocarcinoma cells .
18484897	0	oxygen	36,42	p38MAPK	15,22	oxygen	p38MAPK	MESH:D010100	26416(Tax:10090)	Chemical	Gene	species|compound|START_ENTITY species|amod|END_ENTITY	Involvement of p38MAPK and reactive oxygen species in icariin-induced cardiomyocyte differentiation of murine embryonic stem cells in vitro .
19699266	0	oxygen	140,146	p38_MAPK	156,164	oxygen	p38 MAPK	MESH:D010100	26416(Tax:10090)	Chemical	Gene	species|compound|START_ENTITY species|appos|END_ENTITY	Oleic_acid reduces lipopolysaccharide-induced expression of iNOS and COX-2 in BV2 murine microglial cells : possible involvement of reactive oxygen species , p38_MAPK , and IKK/NF-kappaB signaling pathways .
16024814	0	oxygen	147,153	p38_mitogen-activated_protein_kinase	95,131	oxygen	p38 mitogen-activated protein kinase	MESH:D010100	1432	Chemical	Gene	species|compound|START_ENTITY macrophages|dep|species macrophages|nmod|STAT1/reactive STAT1/reactive|amod|END_ENTITY	Essential role of STAT1 in caspase-independent cell death of activated macrophages through the p38_mitogen-activated_protein_kinase / STAT1/reactive oxygen species pathway .
16192891	0	oxygen	101,107	p38_mitogen-activated_protein_kinase	51,87	oxygen	p38 mitogen-activated protein kinase	MESH:D010100	1432	Chemical	Gene	species|compound|START_ENTITY species|amod|END_ENTITY	Interleukin-1alpha enhances IL-8 secretion through p38_mitogen-activated_protein_kinase and reactive oxygen species signaling in human pancreatic_cancer cells .
10657969	0	oxygen	86,92	p53	40,43	oxygen	p53	MESH:D010100	7157	Chemical	Gene	species|compound|START_ENTITY induced|nmod|species induced|nsubj|mutation mutation|nmod|248 248|nmod|gene gene|compound|END_ENTITY	Transition mutation in codon 248 of the p53 tumor suppressor gene induced by reactive oxygen species and a nitric_oxide-releasing compound .
11291926	0	oxygen	46,52	p53	135,138	oxygen	p53	MESH:D010100	7157	Chemical	Gene	species|compound|START_ENTITY downstream|nmod|species downstream|xcomp|carrying carrying|dobj|gene gene|compound|END_ENTITY	Caspase-3 activation downstream from reactive oxygen species in heat-induced apoptosis of pancreatic_carcinoma cells carrying a mutant p53 gene .
11313880	0	oxygen	78,84	p53	0,3	oxygen	p53	MESH:D010100	7157	Chemical	Gene	species|compound|START_ENTITY regulates|nmod|species regulates|nsubj|END_ENTITY	p53 regulates ceramide formation by neutral sphingomyelinase through reactive oxygen species in human glioma cells .
11368358	0	oxygen	98,104	p53	52,55	oxygen	p53	MESH:D010100	7157	Chemical	Gene	generation|compound|START_ENTITY independent|nmod|generation independent|nsubj|response response|acl|homoharringtonine homoharringtonine|nmod|cells cells|compound|END_ENTITY	Apoptotic response to homoharringtonine in human wt p53 leukemic cells is independent of reactive oxygen species generation and implicates Bax translocation , mitochondrial cytochrome_c release and caspase activation .
11447225	0	oxygen	9,15	p53	51,54	oxygen	p53	MESH:D010100	7157	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Reactive oxygen species-induced phosphorylation of p53 on serine 20 is mediated in part by polo-like_kinase-3 .
12067251	0	oxygen	9,15	p53	90,93	oxygen	p53	MESH:D010100	7157	Chemical	Gene	species|compound|START_ENTITY generated|nsubj|species generated|nmod|END_ENTITY	Reactive oxygen species generated by PAH_o-quinones cause change-in-function mutations in p53 .
14695179	0	oxygen	59,65	p53	26,29	oxygen	p53	MESH:D010100	7157	Chemical	Gene	function|nmod|START_ENTITY function|nsubj|Inactivation Inactivation|nmod|protein protein|compound|END_ENTITY	Inactivation of wild-type p53 protein function by reactive oxygen and nitrogen species in malignant_glioma cells .
14871840	0	oxygen	179,185	p53	145,148	oxygen	p53	MESH:D010100	7157	Chemical	Gene	species|compound|START_ENTITY implication|nmod|species implication|nmod|END_ENTITY	Induction of apoptosis in leukemic cells by homovanillic_acid derivative , capsaicin , through oxidative stress : implication of phosphorylation of p53 at Ser-15 residue by reactive oxygen species .
15342409	0	oxygen	68,74	p53	8,11	oxygen	p53	MESH:D010100	7157	Chemical	Gene	agents|compound|START_ENTITY reactive|dobj|agents sensing|advcl|reactive END_ENTITY|acl|sensing	Role of p53 in sensing oxidative DNA damage in response to reactive oxygen species-generating agents .
15711927	0	oxygen	25,31	p53	8,11	oxygen	p53	MESH:D010100	7157	Chemical	Gene	species|compound|START_ENTITY species|compound|END_ENTITY	Role of p53 and reactive oxygen species in apoptotic response to copper and zinc in epithelial breast_cancer cells .
17145881	0	oxygen	137,143	p53	120,123	oxygen	p53	MESH:D010100	7157	Chemical	Gene	species|compound|START_ENTITY species|compound|END_ENTITY	A novel BH3 mimetic reveals a mitogen-activated protein kinase-dependent mechanism of melanoma cell death controlled by p53 and reactive oxygen species .
18523266	0	oxygen	133,139	p53	157,160	oxygen	p53	MESH:D010100	7157	Chemical	Gene	START_ENTITY|dep|activation activation|compound|END_ENTITY	Proteasome inhibitors enhance TRAIL-induced apoptosis through the intronic regulation of DR5 : involvement of NF-kappa_B and reactive oxygen species-mediated p53 activation .
18676676	0	oxygen	9,15	p53	32,35	oxygen	p53	MESH:D010100	7157	Chemical	Gene	species|compound|START_ENTITY mediate|nsubj|species mediate|dobj|activation activation|compound|END_ENTITY	Reactive oxygen species mediate p53 activation and apoptosis induced by sodium_nitroprusside in SH-SY5Y cells .
18719315	0	oxygen	9,15	p53	73,76	oxygen	p53	MESH:D010100	7157	Chemical	Gene	species|compound|START_ENTITY mediate|nsubj|species mediate|nmod|END_ENTITY	Reactive oxygen species mediate oridonin-induced HepG2 apoptosis through p53 , MAPK , and mitochondrial signaling pathways .
19438509	0	oxygen	9,15	p53	36,39	oxygen	p53	MESH:D010100	7157	Chemical	Gene	species|compound|START_ENTITY species|dep|END_ENTITY	Reactive oxygen species up-regulate p53 and Puma ; a possible mechanism for apoptosis during combined treatment with TRAIL and wogonin .
20298709	0	oxygen	87,93	p53	111,114	oxygen	p53	MESH:D010100	22060(Tax:10090)	Chemical	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Cr -LRB- VI -RRB- induces mitochondrial-mediated and caspase-dependent apoptosis through reactive oxygen species-mediated p53 activation in JB6 Cl41 cells .
20382856	0	oxygen	23,29	p53	41,44	oxygen	p53	MESH:D010100	7157	Chemical	Gene	species|compound|START_ENTITY species|nmod|END_ENTITY	Regulation of reactive oxygen species by p53 : implications for nitric_oxide-mediated apoptosis .
20919943	0	oxygen	104,110	p53	15,18	oxygen	p53	MESH:D010100	7157	Chemical	Gene	production|compound|START_ENTITY control|dobj|production pathways|xcomp|control pathways|nsubj|Interaction Interaction|nmod|END_ENTITY	Interaction of p53 with tumor suppressive and oncogenic signaling pathways to control cellular reactive oxygen species production .
21696969	0	oxygen	94,100	p53	118,121	oxygen	p53	MESH:D010100	7157	Chemical	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	18b-Glycyrrhetinic_acid derivatives induced mitochondrial-mediated apoptosis through reactive oxygen species-mediated p53 activation in NTUB1 cells .
21993662	0	oxygen	75,81	p53	36,39	oxygen	p53	MESH:D010100	7157	Chemical	Gene	species|compound|START_ENTITY pathway|nmod|species pathway|compound|END_ENTITY	Plumbagin induces apoptosis via the p53 pathway and generation of reactive oxygen species in human osteosarcoma cells .
22075967	0	oxygen	118,124	p53	0,3	oxygen	p53	MESH:D010100	22060(Tax:10090)	Chemical	Gene	generation|compound|START_ENTITY caused|nmod|generation diabetic_mellitus|acl|caused promotes|nmod|diabetic_mellitus promotes|nsubj|END_ENTITY	p53 promotes cardiac_dysfunction in diabetic_mellitus caused by excessive mitochondrial respiration-mediated reactive oxygen species generation and lipid accumulation .
22145567	0	oxygen	9,15	p53	33,36	oxygen	p53	MESH:D010100	22060(Tax:10090)	Chemical	Gene	species-mediated|nsubj|START_ENTITY species-mediated|ccomp|determine determine|nsubj|modifications modifications|nummod|END_ENTITY	Reactive oxygen species-mediated p53 core-domain modifications determine apoptotic or necrotic death in cancer cells .
22521640	0	oxygen	77,83	p53	101,104	oxygen	p53	MESH:D010100	7157	Chemical	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	WITHDRAWN : Hexavalent chromium induces premature senescence through reactive oxygen species-mediated p53 pathway in L-02 hepatocytes .
22570471	0	oxygen	115,121	p53	163,166	oxygen	p53	MESH:D010100	7157	Chemical	Gene	species|compound|START_ENTITY species|acl:relcl|mediated mediated|dobj|manner manner|amod|cytotoxicity cytotoxicity|nmod|END_ENTITY	Inhibition of nicotinamide_phosphoribosyltransferase -LRB- NAMPT -RRB- activity by small molecule GMX1778 regulates reactive oxygen species -LRB- ROS -RRB- - mediated cytotoxicity in a p53 - and nicotinic_acid phosphoribosyltransferase1 -LRB- NAPRT1 -RRB- - dependent manner .
22841759	0	oxygen	24,30	p53	56,59	oxygen	p53	MESH:D010100	7157	Chemical	Gene	homeostasis|compound|START_ENTITY homeostasis|nmod|END_ENTITY	Metabolic regulation of oxygen and redox homeostasis by p53 : lessons from evolutionary biology ?
23216635	0	oxygen	9,15	p53	70,73	oxygen	p53	MESH:D010100	7157	Chemical	Gene	Cr|compound|START_ENTITY Cr|acl|induced induced|nmod|END_ENTITY	Reactive oxygen species mediate Cr -LRB- VI -RRB- - induced S phase arrest through p53 in human colon_cancer cells .
23872073	0	oxygen	87,93	p53	70,73	oxygen	p53	MESH:D010100	7157	Chemical	Gene	species|compound|START_ENTITY species|compound|END_ENTITY	Induction of renal fibrotic genes by TGF-b1 requires EGFR activation , p53 and reactive oxygen species .
23942225	0	oxygen	9,15	p53	132,135	oxygen	p53	MESH:D010100	7157	Chemical	Gene	species|compound|START_ENTITY play|nsubj|species play|nmod|roles roles|nmod|END_ENTITY	Reactive oxygen species play a central role in hexavalent chromium-induced apoptosis in Hep3B cells without the functional roles of p53 and caspase-3 .
24005285	0	oxygen	45,51	p53	21,24	oxygen	p53	MESH:D010100	22060(Tax:10090)	Chemical	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	The tumor suppressor p53 fine-tunes reactive oxygen species levels and neurogenesis via PI3 kinase signaling .
24012673	0	oxygen	136,142	p53	161,164	oxygen	p53	MESH:D010100	7157	Chemical	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Depletion of hepatoma-derived_growth_factor-related_protein-3 induces apoptotic sensitization of radioresistant A549 cells via reactive oxygen species-dependent p53 activation .
24308434	0	oxygen	73,79	p53	121,124	oxygen	p53	MESH:D010100	7157	Chemical	Gene	production|compound|START_ENTITY production|nmod|pathway pathway|compound|END_ENTITY	Bendamustine and melphalan kill myeloma cells similarly through reactive oxygen species production and activation of the p53 pathway and do not overcome resistance to each other .
24817286	0	oxygen	17,23	p53	35,38	oxygen	p53	MESH:D010100	301300(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY species|nmod|END_ENTITY	Role of reactive oxygen species in p53 activation during cisplatin-induced apoptosis of rat mesangial cells .
24831807	0	oxygen	124,130	p53	190,193	oxygen	p53	MESH:D010100	7157	Chemical	Gene	species|compound|START_ENTITY generation|nmod|species generation|acl:relcl|induce induce|dobj|response response|appos|stabilization stabilization|nmod|END_ENTITY	Interactions between exosomes from breast_cancer cells and primary mammary epithelial cells leads to generation of reactive oxygen species which induce DNA damage response , stabilization of p53 and autophagy in epithelial cells .
26887694	0	oxygen	10,16	p53	102,105	oxygen	p53	MESH:D010100	7157	Chemical	Gene	pressure|compound|START_ENTITY pressure|nmod|incubation incubation|nmod|B-carrier B-carrier|nmod|capacity capacity|nmod|wild-type wild-type|compound|END_ENTITY	Effect of oxygen pressure during incubation with a -LRB- 10 -RRB- B-carrier on -LRB- 10 -RRB- B uptake capacity of cultured p53 wild-type and mutated tumor cells : dependency on p53 status of tumor cells and types of -LRB- 10 -RRB- B-carriers .
26887694	0	oxygen	10,16	p53	155,158	oxygen	p53	MESH:D010100	7157	Chemical	Gene	pressure|compound|START_ENTITY Effect|nmod|pressure Effect|dep|dependency dependency|nmod|status status|compound|END_ENTITY	Effect of oxygen pressure during incubation with a -LRB- 10 -RRB- B-carrier on -LRB- 10 -RRB- B uptake capacity of cultured p53 wild-type and mutated tumor cells : dependency on p53 status of tumor cells and types of -LRB- 10 -RRB- B-carriers .
26986846	0	oxygen	76,82	p53	107,110	oxygen	p53	MESH:D010100	7157	Chemical	Gene	species|compound|START_ENTITY accumulation|nmod|species induces|nmod|accumulation induces|advmod|irrespective irrespective|nmod|status status|compound|END_ENTITY	PRIMA-1MET induces apoptosis through accumulation of intracellular reactive oxygen species irrespective of p53 status and chemo-sensitivity in epithelial_ovarian_cancer cells .
9074626	0	oxygen	65,71	p53	102,105	oxygen	p53	MESH:D010100	7157	Chemical	Gene	radicals|compound|START_ENTITY proliferating|nmod|radicals apoptosis|acl|proliferating induction|nmod|apoptosis associated|nsubjpass|induction associated|nmod|END_ENTITY	The induction of apoptosis in proliferating human fibroblasts by oxygen radicals is associated with a p53 - and p21WAF1CIP1 induction .
9257692	0	oxygen	7,13	p53	114,117	oxygen	p53	MESH:D010100	7157	Chemical	Gene	species|compound|START_ENTITY mediate|nsubj|species mediate|nmod|END_ENTITY	Active oxygen species mediate the solar ultraviolet radiation-dependent increase in the tumour suppressor protein p53 in human skin fibroblasts .
11641267	0	oxygen	103,109	p90RSK	14,20	oxygen	p90RSK	MESH:D010100	6195	Chemical	Gene	species|compound|START_ENTITY dependent|nmod|species dependent|nsubj|Activation Activation|nmod|stimulation stimulation|amod|END_ENTITY	Activation of p90RSK and growth stimulation of multicellular tumor spheroids are dependent on reactive oxygen species generated after purinergic receptor stimulation by ATP .
15840586	0	oxygen	53,59	p90RSK	33,39	oxygen	p90RSK	MESH:D010100	20112(Tax:10090)	Chemical	Gene	species|compound|START_ENTITY END_ENTITY|nmod|species	Role of p90_ribosomal_S6_kinase -LRB- p90RSK -RRB- in reactive oxygen species and protein_kinase_C_beta -LRB- PKC-beta -RRB- - mediated cardiac_troponin_I phosphorylation .
10636870	0	oxygen	9,15	p90_ribosomal_S6_kinase	33,56	oxygen	p90 ribosomal S6 kinase	MESH:D010100	20112(Tax:10090)	Chemical	Gene	species|compound|START_ENTITY activate|nsubj|species activate|dobj|END_ENTITY	Reactive oxygen species activate p90_ribosomal_S6_kinase via Fyn and Ras .
15840586	0	oxygen	53,59	p90_ribosomal_S6_kinase	8,31	oxygen	p90 ribosomal S6 kinase	MESH:D010100	20112(Tax:10090)	Chemical	Gene	species|compound|START_ENTITY p90RSK|nmod|species p90RSK|amod|END_ENTITY	Role of p90_ribosomal_S6_kinase -LRB- p90RSK -RRB- in reactive oxygen species and protein_kinase_C_beta -LRB- PKC-beta -RRB- - mediated cardiac_troponin_I phosphorylation .
18599872	0	oxygen	9,15	p90_ribosomal_S6_kinase	46,69	oxygen	p90 ribosomal S6 kinase	MESH:D010100	20112(Tax:10090)	Chemical	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Reactive oxygen species-induced activation of p90_ribosomal_S6_kinase prolongs cardiac repolarization through inhibiting outward K + channel activity .
25875582	0	oxygen	51,57	peroxiredoxin_3	23,38	oxygen	peroxiredoxin 3	MESH:D010100	10935	Chemical	Gene	species|compound|START_ENTITY END_ENTITY|nmod|species	The functional role of peroxiredoxin_3 in reactive oxygen species , apoptosis , and chemoresistance of cancer cells .
25875582	0	oxygen	51,57	peroxiredoxin_3	23,38	oxygen	peroxiredoxin 3	MESH:D010100	10935	Chemical	Gene	species|compound|START_ENTITY END_ENTITY|nmod|species	The functional role of peroxiredoxin_3 in reactive oxygen species , apoptosis , and chemoresistance of cancer cells .
1397323	0	oxygen	97,103	phosphoenolpyruvate_carboxykinase	55,88	oxygen	phosphoenolpyruvate carboxykinase	MESH:D010100	362282(Tax:10116)	Chemical	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Modulation of the glucagon-dependent activation of the phosphoenolpyruvate_carboxykinase gene by oxygen in rat hepatocyte cultures .
2050145	0	oxygen	14,20	phosphoenolpyruvate_carboxykinase	65,98	oxygen	phosphoenolpyruvate carboxykinase	MESH:D010100	362282(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|gene gene|amod|END_ENTITY	Modulation by oxygen of the glucagon-dependent activation of the phosphoenolpyruvate_carboxykinase gene in rat hepatocyte cultures .
8373414	0	oxygen	28,34	phosphoenolpyruvate_carboxykinase	99,132	oxygen	phosphoenolpyruvate carboxykinase	MESH:D010100	362282(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY levels|acl:relcl|modulate modulate|dobj|activation activation|nmod|gene gene|amod|END_ENTITY	A ferro-heme protein senses oxygen levels , which modulate the glucagon-dependent activation of the phosphoenolpyruvate_carboxykinase gene in rat hepatocyte cultures .
18558410	0	oxygen	11,17	placental_growth_factor	26,49	oxygen	placental growth factor	MESH:D010100	5228	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Hyperbaric oxygen induces placental_growth_factor expression in bone marrow-derived mesenchymal_stem_cells .
10714632	0	oxygen	52,58	platelet_activating_factor	15,41	oxygen	platelet activating factor	MESH:D010100	300795(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY species|compound|END_ENTITY	Interaction of platelet_activating_factor , reactive oxygen species generated by xanthine oxidase , and leukocytes in the generation of hepatic_injury after shock/resuscitation .
24553432	0	oxygen	108,114	podocin	87,94	oxygen	podocin	MESH:D010100	170672(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY species|compound|END_ENTITY	ATP acting through P2Y receptors causes activation of podocyte TRPC6 channels : role of podocin and reactive oxygen species .
12426206	0	oxygen	71,77	proline-rich_tyrosine_kinase	29,57	oxygen	proline-rich tyrosine kinase	MESH:D010100	541008(Tax:9913)	Chemical	Gene	pathway|compound|START_ENTITY END_ENTITY|nmod|pathway	Fluid shear stress activates proline-rich_tyrosine_kinase via reactive oxygen species-dependent pathway .
22360728	0	oxygen	17,23	prolyl_hydroxylase_2	62,82	oxygen	prolyl hydroxylase 2	MESH:D010100	54583	Chemical	Gene	species|compound|START_ENTITY Role|nmod|species Role|nmod|END_ENTITY	Role of reactive oxygen species in the regulation of HIF-1 by prolyl_hydroxylase_2 under mild hypoxia .
8457474	0	oxygen	104,110	protein_kinase_C	74,90	oxygen	protein kinase C	MESH:D010100	112476	Chemical	Gene	species|compound|START_ENTITY END_ENTITY|nmod|species	UVB radiation exposes fibrinogen binding sites on platelets by activating protein_kinase_C via reactive oxygen species .
16678897	0	oxygen	58,64	protein_tyrosine_phosphatase_1B	14,45	oxygen	protein tyrosine phosphatase 1B	MESH:D010100	5770	Chemical	Gene	species|compound|START_ENTITY END_ENTITY|nmod|species	Inhibition of protein_tyrosine_phosphatase_1B by reactive oxygen species leads to maintenance of Ca2 + influx following store depletion in HEK 293 cells .
12641442	0	oxygen	9,15	pyruvate_dehydrogenase	71,93	oxygen	pyruvate dehydrogenase	MESH:D010100	54704	Chemical	Gene	species|compound|START_ENTITY involved|nsubjpass|species involved|nmod|inhibition inhibition|nmod|activity activity|amod|END_ENTITY	Reactive oxygen species are involved in arsenic_trioxide inhibition of pyruvate_dehydrogenase activity .
8954577	0	oxygen	9,15	pyruvate_dehydrogenase	49,71	oxygen	pyruvate dehydrogenase	MESH:D010100	54704	Chemical	Gene	inactivation|compound|START_ENTITY inactivation|nmod|END_ENTITY	Reactive oxygen species-mediated inactivation of pyruvate_dehydrogenase .
22052977	0	oxygen	45,51	pyruvate_kinase_M2	14,32	oxygen	pyruvate kinase M2	MESH:D010100	5315	Chemical	Gene	species|compound|START_ENTITY END_ENTITY|nmod|species	Inhibition of pyruvate_kinase_M2 by reactive oxygen species contributes to cellular antioxidant responses .
23885364	0	oxygen	130,136	pyruvate_kinase_M2	55,73	oxygen	pyruvate kinase M2	MESH:D010100	5315	Chemical	Gene	species|compound|START_ENTITY levels|nmod|species regulate|dobj|levels inhibition|xcomp|regulate inhibition|nmod|ability ability|amod|END_ENTITY	ML285 affects reactive oxygen species inhibition of pyruvate_kinase_M2 The ability of all cells to regulate levels of reactive oxygen species -LRB- ROS -RRB- is vital for controlling many aspects of proliferation and survival and we have discovered that pyruvate_kinase_M2 -LRB- PKM2 -RRB- is important for cancer cell biology .
23885364	0	oxygen	23,29	pyruvate_kinase_M2	55,73	oxygen	pyruvate kinase M2	MESH:D010100	5315	Chemical	Gene	species|compound|START_ENTITY species|acl|inhibition inhibition|nmod|ability ability|amod|END_ENTITY	ML285 affects reactive oxygen species inhibition of pyruvate_kinase_M2 The ability of all cells to regulate levels of reactive oxygen species -LRB- ROS -RRB- is vital for controlling many aspects of proliferation and survival and we have discovered that pyruvate_kinase_M2 -LRB- PKM2 -RRB- is important for cancer cell biology .
26774701	0	oxygen	45,51	pyruvate_kinase_M2	14,32	oxygen	pyruvate kinase M2	MESH:D010100	25630(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY END_ENTITY|nmod|species	Inhibition of pyruvate_kinase_M2 by reactive oxygen species contributes to the development of pulmonary_arterial_hypertension .
26131370	0	oxygen	74,80	sclerostin	49,59	oxygen	sclerostin	MESH:D010100	50964	Chemical	Gene	species|compound|START_ENTITY END_ENTITY|nmod|species	Hyperglycemia increases the expression levels of sclerostin in a reactive oxygen species - and tumor_necrosis_factor-alpha-dependent manner .
26339526	1	oxygen	143,149	sclerostin	118,128	oxygen	sclerostin	MESH:D010100	50964	Chemical	Gene	species|compound|START_ENTITY END_ENTITY|nmod|species	Hyperglycemia increases the expression levels of sclerostin in a reactive oxygen species - and tumor_necrosis_factor-alpha-dependent manner .
18646723	0	oxygen	109,115	six_transmembrane_epithelial_antigen_of_the_prostate-1	28,82	oxygen	six transmembrane epithelial antigen of the prostate-1	MESH:D010100	26872	Chemical	Gene	species|compound|START_ENTITY END_ENTITY|nmod|species	-LSB- Influence of expression of six_transmembrane_epithelial_antigen_of_the_prostate-1 on intracellular reactive oxygen species level and cell growth : an in vitro experiment -RSB- .
22695329	0	oxygen	52,58	stanniocalcin-1	18,33	oxygen	stanniocalcin-1	MESH:D010100	20855(Tax:10090)	Chemical	Gene	species|compound|START_ENTITY species|amod|END_ENTITY	Overexpression of stanniocalcin-1 inhibits reactive oxygen species and renal_ischemia / reperfusion injury in mice .
16783004	0	oxygen	28,34	sterol	11,17	oxygen	Ecm22p	MESH:D010100	850928(Tax:4932)	Chemical	Gene	levels|nmod|START_ENTITY levels|amod|END_ENTITY	A role for sterol levels in oxygen sensing in Saccharomyces_cerevisiae .
23637859	0	oxygen	83,89	substance_P	50,61	oxygen	substance P	MESH:D010100	21333(Tax:10090)	Chemical	Gene	species|compound|START_ENTITY mediated|nmod|species END_ENTITY|acl|mediated	Chronic restraint stress inhibits hair growth via substance_P mediated by reactive oxygen species in mice .
10850363	0	oxygen	56,62	superoxide_dismutase	116,136	oxygen	superoxide dismutase	MESH:D010100	6647	Chemical	Gene	species|compound|START_ENTITY reactive|dobj|species reactive|nmod|mimics mimics|nmod|END_ENTITY	Susceptibility of natural killer -LRB- NK -RRB- cells to reactive oxygen species -LRB- ROS -RRB- and their restoration by the mimics of superoxide_dismutase -LRB- SOD -RRB- .
1290975	0	oxygen	97,103	superoxide_dismutase	35,55	oxygen	superoxide dismutase	MESH:D010100	6647	Chemical	Gene	-RSB-|compound|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- Increased activity of erythrocyte superoxide_dismutase as the result of adaptation to long-term oxygen therapy -RSB- .
16326710	0	oxygen	23,29	superoxide_dismutase	54,74	oxygen	superoxide dismutase	MESH:D010100	20656(Tax:10090)	Chemical	Gene	species|compound|START_ENTITY species|nmod|mice mice|acl|lacking lacking|xcomp|END_ENTITY	Mitochondrial reactive oxygen species in mice lacking superoxide_dismutase 2 : attenuation via antioxidant treatment .
9541139	0	oxygen	47,53	superoxide_dismutase	55,75	oxygen	superoxide dismutase	MESH:D010100	6647	Chemical	Gene	state|compound|START_ENTITY state|dep|END_ENTITY	Behavior pattern , arterial partial pressure of oxygen , superoxide_dismutase , micro-blood-flow state and longevity or aging .
1733279	0	oxygen	20,26	surfactant_protein_B	30,50	oxygen	surfactant protein B	MESH:D010100	20388(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|amod|END_ENTITY	Distinct effects of oxygen on surfactant_protein_B expression in bronchiolar and alveolar epithelium .
17511584	0	oxygen	5,11	thioredoxin	46,57	oxygen	thioredoxin	MESH:D010100	7295	Chemical	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	From oxygen sensing to heart_failure : role of thioredoxin .
19369702	0	oxygen	9,15	thioredoxin	49,60	oxygen	thioredoxin	MESH:D010100	7295	Chemical	Gene	oxidation|compound|START_ENTITY oxidation|nmod|END_ENTITY	Reactive oxygen species-independent oxidation of thioredoxin in hypoxia : inactivation of ribonucleotide reductase and redox-mediated checkpoint control .
8362375	0	oxygen	9,15	tissue_plasminogen_activator	70,98	oxygen	tissue plasminogen activator	MESH:D010100	25692(Tax:10116)	Chemical	Gene	intermediates|compound|START_ENTITY END_ENTITY|nsubj|intermediates	Reactive oxygen intermediates and ischemia-reperfusion injury release tissue_plasminogen_activator from isolated rat hearts .
12763041	0	oxygen	72,78	tissue_transglutaminase	22,45	oxygen	tissue transglutaminase	MESH:D010100	7052	Chemical	Gene	species|compound|START_ENTITY END_ENTITY|nmod|species	Activation of in situ tissue_transglutaminase by intracellular reactive oxygen species .
15541364	0	oxygen	105,111	tissue_transglutaminase	27,50	oxygen	tissue transglutaminase	MESH:D010100	21817(Tax:10090)	Chemical	Gene	species|compound|START_ENTITY formation|nmod|species formation|compound|END_ENTITY	Arachidonic_acid activates tissue_transglutaminase and stress fiber formation via intracellular reactive oxygen species .
15920727	0	oxygen	58,64	toll-like_receptor_4	24,44	oxygen	toll-like receptor 4	MESH:D010100	29260(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY species|amod|END_ENTITY	Interactive role of the toll-like_receptor_4 and reactive oxygen species in LPS-induced microglia activation .
21957979	0	oxygen	185,191	toll-like_receptor_4	104,124	oxygen	toll-like receptor 4	MESH:D010100	21898(Tax:10090)	Chemical	Gene	trafficking|compound|START_ENTITY dismutase|dobj|trafficking mediated|parataxis|dismutase mediated|nmod|inhibition inhibition|nmod|pathway pathway|amod|END_ENTITY	Superoxide dismutase 3 suppresses hyaluronic acid fragments mediated skin_inflammation by inhibition of toll-like_receptor_4 signaling pathway : superoxide dismutase 3 inhibits reactive oxygen species-induced trafficking of toll-like_receptor_4 to lipid rafts .
21957979	0	oxygen	185,191	toll-like_receptor_4	223,243	oxygen	toll-like receptor 4	MESH:D010100	21898(Tax:10090)	Chemical	Gene	trafficking|compound|START_ENTITY trafficking|nmod|rafts rafts|amod|END_ENTITY	Superoxide dismutase 3 suppresses hyaluronic acid fragments mediated skin_inflammation by inhibition of toll-like_receptor_4 signaling pathway : superoxide dismutase 3 inhibits reactive oxygen species-induced trafficking of toll-like_receptor_4 to lipid rafts .
25826119	0	oxygen	65,71	toll-like_receptor_4	24,44	oxygen	toll-like receptor 4	MESH:D010100	7099	Chemical	Gene	intermediates|compound|START_ENTITY intermediates|amod|END_ENTITY	Neutrophil and monocyte toll-like_receptor_4 , CD11b and reactive oxygen intermediates , and neuroimaging outcomes in preterm infants .
21304968	0	oxygen	109,115	transglutaminase_2	56,74	oxygen	transglutaminase 2	MESH:D010100	7052	Chemical	Gene	deprivation|compound|START_ENTITY death|nmod|deprivation potentiates|dobj|death potentiates|nsubj|form form|nmod|END_ENTITY	Cytosolic guanine_nucledotide binding deficient form of transglutaminase_2 -LRB- R580a -RRB- potentiates cell death in oxygen glucose deprivation .
22923476	0	oxygen	94,100	transglutaminase_2	118,136	oxygen	transglutaminase 2	MESH:D010100	21817(Tax:10090)	Chemical	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	C-peptide prevents hyperglycemia-induced endothelial apoptosis through inhibition of reactive oxygen species-mediated transglutaminase_2 activation .
19709383	0	oxygen	24,30	tropoelastin	60,72	oxygen	tropoelastin	MESH:D010100	2006	Chemical	Gene	species|compound|START_ENTITY Involvement|nmod|species Involvement|nmod|expression expression|compound|END_ENTITY	Involvement of reactive oxygen species in TGF-beta1-induced tropoelastin expression by human dermal fibroblasts .
9808343	0	oxygen	49,55	tropoelastin	24,36	oxygen	tropoelastin	MESH:D010100	2006	Chemical	Gene	species|compound|START_ENTITY END_ENTITY|nmod|species	In vitro degradation of tropoelastin by reactive oxygen species .
11289709	1	oxygen	188,194	tumor_necrosis_Factor-alpha	100,127	oxygen	tumor necrosis Factor-alpha	MESH:D010100	7124	Chemical	Gene	radicals|compound|START_ENTITY generation|nmod|radicals measured|nmod|generation neutrophils|acl|measured priming|nmod|neutrophils priming|amod|END_ENTITY	Increase in tumor_necrosis_Factor-alpha priming of peripheral neutrophils measured as generation of oxygen radicals .
11298495	0	oxygen	119,125	tumor_necrosis_factor-alpha	49,76	oxygen	tumor necrosis factor-alpha	MESH:D010100	7124	Chemical	Gene	species|compound|START_ENTITY stimulates|nmod|species stimulates|dobj|release release|amod|END_ENTITY	Trimethyltin-activated cyclooxygenase stimulates tumor_necrosis_factor-alpha release from glial cells through reactive oxygen species .
11415943	0	oxygen	15,21	tumor_necrosis_factor-alpha	89,116	oxygen	tumor necrosis factor-alpha	MESH:D010100	7124	Chemical	Gene	production|compound|START_ENTITY production|nmod|mitochondria mitochondria|nmod|cells cells|acl|exposed exposed|nmod|END_ENTITY	Rapid reactive oxygen species production by mitochondria in endothelial cells exposed to tumor_necrosis_factor-alpha is mediated by ceramide .
12929751	0	oxygen	69,75	tumor_necrosis_factor-alpha	13,40	oxygen	tumor necrosis factor-alpha	MESH:D010100	7124	Chemical	Gene	intermediates|compound|START_ENTITY role|nmod|intermediates Induction|dep|role Induction|nmod|END_ENTITY	Induction of tumor_necrosis_factor-alpha by UVB : a role for reactive oxygen intermediates and eicosanoids .
14973143	0	oxygen	90,96	tumor_necrosis_factor-alpha	44,71	oxygen	tumor necrosis factor-alpha	MESH:D010100	7124	Chemical	Gene	species|compound|START_ENTITY role|nmod|species END_ENTITY|dep|role	Impairment of HERG K -LRB- + -RRB- channel function by tumor_necrosis_factor-alpha : role of reactive oxygen species as a mediator .
15809210	0	oxygen	117,123	tumor_necrosis_factor-alpha	44,71	oxygen	tumor necrosis factor-alpha	MESH:D010100	7124	Chemical	Gene	supplementation|compound|START_ENTITY duration|nmod|supplementation -308|nmod|duration -308|nsubj|association association|nmod|state state|nmod|END_ENTITY	The association of the carrier state of the tumor_necrosis_factor-alpha -LRB- TNFalpha -RRB- -308 A allele with the duration of oxygen supplementation in preterm neonates .
16713603	0	oxygen	208,214	tumor_necrosis_factor-alpha	53,80	oxygen	tumor necrosis factor-alpha	MESH:D010100	7124	Chemical	Gene	species|compound|START_ENTITY END_ENTITY|dep|species	Salvianolic_acid_B from Salvia miltiorrhiza inhibits tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- - induced MMP-2 upregulation in human aortic smooth muscle cells via suppression of NAD -LRB- P -RRB- H oxidase-derived reactive oxygen species .
17049893	0	oxygen	24,30	tumor_necrosis_factor-alpha	34,61	oxygen	tumor necrosis factor-alpha	MESH:D010100	24835(Tax:10116)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|production production|compound|END_ENTITY	Influence of hyperbaric oxygen on tumor_necrosis_factor-alpha and nitric_oxide production in endotoxin-induced acute_lung_injury in rats .
17094942	0	oxygen	140,146	tumor_necrosis_factor-alpha	48,75	oxygen	tumor necrosis factor-alpha	MESH:D010100	24835(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY role|nmod|species inhibits|parataxis|role inhibits|dobj|expression expression|amod|END_ENTITY	Simvastatin inhibits lipopolysaccharide-induced tumor_necrosis_factor-alpha expression in neonatal rat cardiomyocytes : The role of reactive oxygen species .
18268422	0	oxygen	20,26	tumor_necrosis_factor-alpha	66,93	oxygen	tumor necrosis factor-alpha	MESH:D010100	7124	Chemical	Gene	therapy|compound|START_ENTITY increases|nsubj|therapy increases|xcomp|circulating circulating|dobj|level level|nmod|END_ENTITY	Effective nocturnal oxygen therapy increases circulating level of tumor_necrosis_factor-alpha in heart_failure .
20479003	0	oxygen	125,131	tumor_necrosis_factor-alpha	53,80	oxygen	tumor necrosis factor-alpha	MESH:D010100	21926(Tax:10090)	Chemical	Gene	production|compound|START_ENTITY requires|dobj|production requires|nsubj|Activation Activation|nmod|current current|nmod|END_ENTITY	Activation of swelling-activated chloride current by tumor_necrosis_factor-alpha requires ClC-3-dependent endosomal reactive oxygen production .
21372295	0	oxygen	101,107	tumor_necrosis_factor-alpha	136,163	oxygen	tumor necrosis factor-alpha	MESH:D010100	21926(Tax:10090)	Chemical	Gene	release|compound|START_ENTITY release|nmod|activation activation|amod|END_ENTITY	Early inflammatory reactions in atherosclerosis are induced by proline-rich_tyrosine_kinase / reactive oxygen species-mediated release of tumor_necrosis_factor-alpha and subsequent activation of the p21Cip1/Ets -1 / p300 system .
7539275	0	oxygen	18,24	tumor_necrosis_factor-alpha	57,84	oxygen	tumor necrosis factor-alpha	MESH:D010100	24835(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY species|nmod|response response|amod|END_ENTITY	Iron and reactive oxygen species in the asbestos-induced tumor_necrosis_factor-alpha response from alveolar macrophages .
7883956	0	oxygen	68,74	tumor_necrosis_factor-alpha	28,55	oxygen	tumor necrosis factor-alpha	MESH:D010100	7124	Chemical	Gene	uptake|compound|START_ENTITY END_ENTITY|nmod|uptake	Effect of recombinant human tumor_necrosis_factor-alpha on cerebral oxygen uptake , cerebrospinal fluid lactate , and cerebral blood flow in the rabbit : role of nitric_oxide .
12009413	0	oxygen	56,62	tyrosinase	82,92	oxygen	tyrosinase	MESH:D010100	7299	Chemical	Gene	consumption|compound|START_ENTITY consumption|nmod|END_ENTITY	Mechanistic implications of variable stoichiometries of oxygen consumption during tyrosinase catalyzed oxidation of monophenols and o-diphenols .
19335094	0	oxygen	104,110	tyrosine_hydroxylase	41,61	oxygen	tyrosine hydroxylase	MESH:D010100	25085(Tax:10116)	Chemical	Gene	downregulation|compound|START_ENTITY role|nmod|downregulation phosphatase|nsubj|role sustained|parataxis|phosphatase sustained|dobj|activation activation|nmod|END_ENTITY	Pattern-specific sustained activation of tyrosine_hydroxylase by intermittent_hypoxia : role of reactive oxygen species-dependent downregulation of protein phosphatase 2A and upregulation of protein kinases .
2888478	0	oxygen	13,19	tyrosine_hydroxylase	34,54	oxygen	tyrosine hydroxylase	MESH:D010100	7054	Chemical	Gene	Mechanism|nmod|START_ENTITY activation|nsubj|Mechanism activation|nmod|END_ENTITY	Mechanism of oxygen activation by tyrosine_hydroxylase .
8978742	0	oxygen	23,29	tyrosine_hydroxylase	41,61	oxygen	tyrosine hydroxylase	MESH:D010100	7054	Chemical	Gene	species|compound|START_ENTITY species|nmod|END_ENTITY	Generation of reactive oxygen species by tyrosine_hydroxylase : a possible contribution to the degeneration_of_dopaminergic_neurons ?
9027744	0	oxygen	75,81	tyrosine_hydroxylase	35,55	oxygen	tyrosine hydroxylase	MESH:D010100	25085(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Post-transcriptional regulation of tyrosine_hydroxylase gene expression by oxygen in PC12 cells .
21984579	0	oxygen	50,56	uncoupling_protein_2	10,30	oxygen	uncoupling protein 2	MESH:D010100	22228(Tax:10090)	Chemical	Gene	production|compound|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	Beta-cell uncoupling_protein_2 regulates reactive oxygen species production , which influences both insulin and glucagon secretion .
15870884	0	oxygen	81,87	urokinase_plasminogen_activator_receptor	104,144	oxygen	urokinase plasminogen activator receptor	MESH:D010100	5329	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Extracellular signal-regulated kinase and AP-1 pathways are involved in reactive oxygen species-induced urokinase_plasminogen_activator_receptor expression in human gastric_cancer cells .
17334646	0	oxygen	122,128	urokinase_plasminogen_activator_receptor	31,71	oxygen	urokinase plasminogen activator receptor	MESH:D010100	5329	Chemical	Gene	species|compound|START_ENTITY stimulates|nmod|species stimulates|dobj|expression expression|compound|END_ENTITY	Helicobacter_pylori stimulates urokinase_plasminogen_activator_receptor expression and cell invasiveness through reactive oxygen species and NF-kappaB signaling in human gastric_carcinoma cells .
10408392	0	oxygen	44,50	vascular_endothelial_growth_factor	94,128	oxygen	vascular endothelial growth factor	MESH:D010100	7422	Chemical	Gene	levels|compound|START_ENTITY reduction|nmod|levels analysis|nmod|reduction required|nsubj|analysis required|xcomp|induce induce|dobj|up-regulation up-regulation|nmod|mRNA mRNA|amod|END_ENTITY	A quantitative analysis of the reduction in oxygen levels required to induce up-regulation of vascular_endothelial_growth_factor -LRB- VEGF -RRB- mRNA in cervical_cancer cell lines .
11557687	0	oxygen	112,118	vascular_endothelial_growth_factor	16,50	oxygen	vascular endothelial growth factor	MESH:D010100	7422	Chemical	Gene	species|compound|START_ENTITY role|nmod|species causes|parataxis|role causes|dobj|expression expression|compound|END_ENTITY	Thrombin causes vascular_endothelial_growth_factor expression in vascular smooth muscle cells : role of reactive oxygen species .
11719508	0	oxygen	9,15	vascular_endothelial_growth_factor	75,109	oxygen	vascular endothelial growth factor	MESH:D010100	7422	Chemical	Gene	species|compound|START_ENTITY species|acl|signaling signaling|nmod|KDR KDR|amod|END_ENTITY	Reactive oxygen species as downstream mediators of angiogenic signaling by vascular_endothelial_growth_factor receptor-2 / KDR .
11937295	0	oxygen	9,15	vascular_endothelial_growth_factor	49,83	oxygen	vascular endothelial growth factor	MESH:D010100	22339(Tax:10090)	Chemical	Gene	species|compound|START_ENTITY accelerate|nsubj|species accelerate|dobj|production production|nmod|END_ENTITY	Reactive oxygen species accelerate production of vascular_endothelial_growth_factor by advanced glycation end products in RAW264 .7 mouse macrophages .
12924491	0	oxygen	11,17	vascular_endothelial_growth_factor	52,86	oxygen	vascular endothelial growth factor	MESH:D010100	7422	Chemical	Gene	administration|compound|START_ENTITY Effects|nmod|administration Effects|nmod|levels levels|compound|END_ENTITY	Effects of oxygen administration on the circulating vascular_endothelial_growth_factor -LRB- VEGF -RRB- levels in patients with obstructive_sleep_apnea_syndrome .
14554226	0	oxygen	47,53	vascular_endothelial_growth_factor	57,91	oxygen	vascular endothelial growth factor	MESH:D010100	83785(Tax:10116)	Chemical	Gene	injection|nmod|START_ENTITY topical|dobj|injection topical|nmod|gene gene|compound|END_ENTITY	Effects of transcutaneous topical injection of oxygen on vascular_endothelial_growth_factor gene into the healing ligament in rats .
15217908	0	oxygen	101,107	vascular_endothelial_growth_factor	16,50	oxygen	vascular endothelial growth factor	MESH:D010100	83785(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY involved|nmod|species involved|nsubjpass|IQGAP1 IQGAP1|appos|receptor receptor|compound|END_ENTITY	IQGAP1 , a novel vascular_endothelial_growth_factor receptor binding protein , is involved in reactive oxygen species -- dependent endothelial migration and proliferation .
15841086	0	oxygen	97,103	vascular_endothelial_growth_factor	137,171	oxygen	vascular endothelial growth factor	MESH:D010100	7422	Chemical	Gene	species|compound|START_ENTITY expression|nmod|species stimulation|nmod|expression stimulation|dep|effect effect|acl|targeting targeting|dobj|stress stress|compound|END_ENTITY	Cooperative stimulation of vascular_endothelial_growth_factor expression by hypoxia and reactive oxygen species : the effect of targeting vascular_endothelial_growth_factor and oxidative stress in an orthotopic xenograft model of bladder_carcinoma .
15841086	0	oxygen	97,103	vascular_endothelial_growth_factor	27,61	oxygen	vascular endothelial growth factor	MESH:D010100	7422	Chemical	Gene	species|compound|START_ENTITY expression|nmod|species expression|compound|END_ENTITY	Cooperative stimulation of vascular_endothelial_growth_factor expression by hypoxia and reactive oxygen species : the effect of targeting vascular_endothelial_growth_factor and oxidative stress in an orthotopic xenograft model of bladder_carcinoma .
16513203	0	oxygen	11,17	vascular_endothelial_growth_factor	26,60	oxygen	vascular endothelial growth factor	MESH:D010100	83785(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Hyperbaric oxygen induces vascular_endothelial_growth_factor and reduces liver_injury in regenerating rat liver after partial hepatectomy .
16707486	0	oxygen	138,144	vascular_endothelial_growth_factor	162,196	oxygen	vascular endothelial growth factor	MESH:D010100	83785(Tax:10116)	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Pigment_epithelium-derived_factor inhibits advanced glycation end product-induced retinal_vascular_hyperpermeability by blocking reactive oxygen species-mediated vascular_endothelial_growth_factor expression .
17045920	0	oxygen	9,15	vascular_endothelial_growth_factor	65,99	oxygen	vascular endothelial growth factor	MESH:D010100	7422	Chemical	Gene	species|compound|START_ENTITY regulate|nsubj|species regulate|dobj|END_ENTITY	Reactive oxygen species regulate epidermal growth factor-induced vascular_endothelial_growth_factor and hypoxia-inducible factor-1alpha expression through activation of AKT and P70S6K1 in human ovarian_cancer cells .
17187682	0	oxygen	9,15	vascular_endothelial_growth_factor	45,79	oxygen	vascular endothelial growth factor	MESH:D010100	7422	Chemical	Gene	species|compound|START_ENTITY induce|nsubj|species induce|dobj|expression expression|nmod|END_ENTITY	Reactive oxygen species induce expression of vascular_endothelial_growth_factor in chondrocytes and human articular cartilage explants .
17210799	0	oxygen	66,72	vascular_endothelial_growth_factor	14,48	oxygen	vascular endothelial growth factor	MESH:D010100	7422	Chemical	Gene	species|compound|START_ENTITY END_ENTITY|nmod|species	Activation of vascular_endothelial_growth_factor through reactive oxygen species mediates 20-hydroxyeicosatetraenoic_acid-induced endothelial cell proliferation .
18006827	0	oxygen	9,15	vascular_endothelial_growth_factor	71,105	oxygen	vascular endothelial growth factor	MESH:D010100	7422	Chemical	Gene	species|compound|START_ENTITY regulate|nsubj|species regulate|nmod|END_ENTITY	Reactive oxygen species regulate angiogenesis and tumor growth through vascular_endothelial_growth_factor .
18206401	0	oxygen	11,17	vascular_endothelial_growth_factor	39,73	oxygen	vascular endothelial growth factor	MESH:D010100	100008899(Tax:9986)	Chemical	Gene	results|compound|START_ENTITY results|nmod|END_ENTITY	Hyperbaric oxygen results in increased vascular_endothelial_growth_factor -LRB- VEGF -RRB- protein expression in rabbit calvarial critical-sized defects .
18322419	0	oxygen	82,88	vascular_endothelial_growth_factor	19,53	oxygen	vascular endothelial growth factor	MESH:D010100	7422	Chemical	Gene	production|compound|START_ENTITY induces|nmod|production induces|dobj|expression expression|compound|END_ENTITY	Paclitaxel induces vascular_endothelial_growth_factor expression through reactive oxygen species production .
19788349	0	oxygen	119,125	vascular_endothelial_growth_factor	160,194	oxygen	vascular endothelial growth factor	MESH:D010100	22339(Tax:10090)	Chemical	Gene	up-regulation|compound|START_ENTITY up-regulation|nmod|END_ENTITY	Static electromagnetic fields induce vasculogenesis and chondro-osteogenesis of mouse embryonic_stem cells by reactive oxygen species-mediated up-regulation of vascular_endothelial_growth_factor .
20113663	0	oxygen	56,62	vascular_endothelial_growth_factor	80,114	oxygen	vascular endothelial growth factor	MESH:D010100	83785(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of prolonged exposure of high concentration of oxygen on expression of vascular_endothelial_growth_factor and its receptors in neonatal rat lungs -RSB- .
20332345	0	oxygen	23,29	vascular_endothelial_growth_factor	66,100	oxygen	vascular endothelial growth factor	MESH:D010100	22339(Tax:10090)	Chemical	Gene	species|compound|START_ENTITY Inhibition|nmod|species downregulates|nsubj|Inhibition downregulates|dobj|expression expression|compound|END_ENTITY	Inhibition of reactive oxygen species by Lovastatin downregulates vascular_endothelial_growth_factor expression and ameliorates blood-retinal barrier breakdown in db/db mice : role of NADPH_oxidase_4 .
21176170	0	oxygen	25,31	vascular_endothelial_growth_factor	65,99	oxygen	vascular endothelial growth factor	MESH:D010100	7422	Chemical	Gene	therapy|compound|START_ENTITY impact|nmod|therapy impact|nmod|END_ENTITY	The impact of hyperbaric oxygen therapy on serological values of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and basic_fibroblast_growth_factor -LRB- bFGF -RRB- .
21296593	0	oxygen	112,118	vascular_endothelial_growth_factor	135,169	oxygen	vascular endothelial growth factor	MESH:D010100	281572(Tax:9913)	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Advanced glycation end products increase permeability of brain microvascular endothelial cells through reactive oxygen species-induced vascular_endothelial_growth_factor expression .
21636804	0	oxygen	217,223	vascular_endothelial_growth_factor	143,177	oxygen	vascular endothelial growth factor	MESH:D010100	7422	Chemical	Gene	species|compound|START_ENTITY transactivation|nmod|species transactivation|compound|END_ENTITY	Thioredoxin-interacting_protein mediates TRX1 translocation to the plasma membrane in response to tumor_necrosis_factor-a : a key mechanism for vascular_endothelial_growth_factor receptor-2 transactivation by reactive oxygen species .
22041018	0	oxygen	162,168	vascular_endothelial_growth_factor	66,100	oxygen	vascular endothelial growth factor	MESH:D010100	7422	Chemical	Gene	species|compound|START_ENTITY role|nmod|species up-regulation|dep|role up-regulation|nmod|END_ENTITY	Recombinant bone_morphogenetic_protein-2 induces up-regulation of vascular_endothelial_growth_factor and interleukin_6 in human pre-osteoblasts : role of reactive oxygen species .
22153388	0	oxygen	150,156	vascular_endothelial_growth_factor	21,55	oxygen	vascular endothelial growth factor	MESH:D010100	7422	Chemical	Gene	production|compound|START_ENTITY inhibition|nmod|production non-small_cell_lung_carcinomas|nmod|inhibition expression|nmod|non-small_cell_lung_carcinomas expression|amod|END_ENTITY	Atorvastatin reduces vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in human non-small_cell_lung_carcinomas -LRB- NSCLCs -RRB- via inhibition of reactive oxygen species -LRB- ROS -RRB- production .
23274526	0	oxygen	114,120	vascular_endothelial_growth_factor	21,55	oxygen	vascular endothelial growth factor	MESH:D010100	7422	Chemical	Gene	generation|compound|START_ENTITY induces|nmod|generation induces|dobj|production production|compound|END_ENTITY	High glucose induces vascular_endothelial_growth_factor production in human synovial fibroblasts through reactive oxygen species generation .
23385964	0	oxygen	112,118	vascular_endothelial_growth_factor	12,46	oxygen	vascular endothelial growth factor	MESH:D010100	83785(Tax:10116)	Chemical	Gene	inspired|dobj|START_ENTITY inspired|nsubj|Response Response|nmod|genes genes|compound|END_ENTITY	Response of vascular_endothelial_growth_factor and angiogenesis-related genes to stepwise increases in inspired oxygen in neonatal rat lungs .
23404377	0	oxygen	9,15	vascular_endothelial_growth_factor	59,93	oxygen	vascular endothelial growth factor	MESH:D010100	7422	Chemical	Gene	species|compound|START_ENTITY regulate|nsubj|species regulate|dobj|expression expression|nmod|END_ENTITY	Reactive oxygen species regulate FSH-induced expression of vascular_endothelial_growth_factor via Nrf2 and HIF1a signaling in human epithelial_ovarian_cancer .
23762849	0	oxygen	91,97	vascular_endothelial_growth_factor	22,56	oxygen	vascular endothelial growth factor	MESH:D010100	7422	Chemical	Gene	species|compound|START_ENTITY generation|nmod|species inhibits|nmod|generation inhibits|dobj|release release|compound|END_ENTITY	Sanguinarine inhibits vascular_endothelial_growth_factor release by generation of reactive oxygen species in MCF-7 human mammary adenocarcinoma cells .
25192544	0	oxygen	147,153	vascular_endothelial_growth_factor	190,224	oxygen	vascular endothelial growth factor	MESH:D010100	7422	Chemical	Gene	species/hypoxia-inducible|compound|START_ENTITY species/hypoxia-inducible|acl|_ _|dobj|END_ENTITY	Scutellarin inhibits high glucose-induced and hypoxia-mimetic agent-induced angiogenic effects in human retinal endothelial cells through reactive oxygen species/hypoxia-inducible _ factor-1a / vascular_endothelial_growth_factor pathway .
26518179	0	oxygen	79,85	vascular_endothelial_growth_factor	27,61	oxygen	vascular endothelial growth factor	MESH:D010100	83785(Tax:10116)	Chemical	Gene	delivery|compound|START_ENTITY effect|nmod|delivery effect|nmod|END_ENTITY	The effect of intravitreal vascular_endothelial_growth_factor on inner retinal oxygen delivery and metabolism in rats .
7548442	0	oxygen	127,133	vascular_endothelial_growth_factor	30,64	oxygen	vascular endothelial growth factor	MESH:D010100	7422	Chemical	Gene	concentration|compound|START_ENTITY function|nmod|concentration rates|nmod|function rates|nmod|END_ENTITY	Secretion rates and levels of vascular_endothelial_growth_factor in clone A or HCT-8 human colon_tumour cells as a function of oxygen concentration .
8833917	0	oxygen	9,15	vascular_endothelial_growth_factor	39,73	oxygen	vascular endothelial growth factor	MESH:D010100	7422	Chemical	Gene	intermediates|compound|START_ENTITY increase|nsubj|intermediates increase|dobj|expression expression|compound|END_ENTITY	Reactive oxygen intermediates increase vascular_endothelial_growth_factor expression in vitro and in vivo .
8859081	0	oxygen	52,58	vascular_endothelial_growth_factor	14,48	oxygen	vascular endothelial growth factor	MESH:D010100	7422	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of vascular_endothelial_growth_factor by oxygen in a model of retinopathy_of_prematurity .
9194664	0	oxygen	76,82	vascular_endothelial_growth_factor	129,163	oxygen	vascular endothelial growth factor	MESH:D010100	7422	Chemical	Gene	content|compound|START_ENTITY content|dep|association association|nmod|levels levels|compound|END_ENTITY	The developmental potential of the human oocyte is related to the dissolved oxygen content of follicular fluid : association with vascular_endothelial_growth_factor levels and perifollicular blood flow characteristics .
4319568	0	oxygen	56,62	vasopressin	11,22	oxygen	vasopressin	MESH:D010100	551	Chemical	Gene	consumption|compound|START_ENTITY END_ENTITY|nmod|consumption	Effects of vasopressin , cyclic_AMP , and theophylline on oxygen consumption of toad bladder `` sacs '' .
22798714	0	oxygen	46,52	xanthine_dehydrogenase	65,87	oxygen	xanthine dehydrogenase	MESH:D010100	497811(Tax:10116)	Chemical	Gene	species|compound|START_ENTITY species|nmod|END_ENTITY	All-trans Arachidonic_acid generates reactive oxygen species via xanthine_dehydrogenase / xanthine oxidase interconversion in the rat liver cytosol in vitro .
20848897	0	oxygenmedicine	36,50	Bcl-2	72,77	oxygenmedicine	Bcl-2	null	24224(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|proteins proteins|amod|END_ENTITY	-LSB- Effects of electroacupuncture plus oxygenmedicine on the expression of Bcl-2 and Bax proteins in the hippocampal CA_1 area in rats with global cerebral_ischemia / reperfusion injury -RSB- .
7934100	0	oxyhemoglobin	38,51	hemoglobin	10,20	oxyhemoglobin	hemoglobin	CHEBI:7861	100323610(Tax:9823)	Chemical	Gene	concentration|nmod|START_ENTITY concentration|compound|END_ENTITY	Effect of hemoglobin concentration on oxyhemoglobin dissociation during hypothermic blood cardioplegic_arrest .
3012163	0	oxylic_acid	94,105	angiotensin_converting_enzyme	131,160	oxylic acid	angiotensin converting enzyme	null	24310(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Species difference of -LRB- 2R ,4 R -RRB- -2 - -LRB- o-hydroxyphenyl -RRB- -3 - -LRB- 3-mercaptopropionyl -RRB- -4 - thiazolidinec arb oxylic_acid -LRB- SA446 -RRB- in inhibition of angiotensin_converting_enzyme .
17638069	0	oxylipin	8,16	cyclin_D1	109,118	oxylipin	cyclin D1	CHEBI:61121	595	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	A plant oxylipin , 12-oxo-phytodienoic_acid , inhibits proliferation of human breast_cancer cells by targeting cyclin_D1 .
17357477	0	oxymatrine	21,31	TNF-alpha	63,72	oxymatrine	TNF-alpha	MESH:C037573	24835(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|nmod|END_ENTITY	Inhibitory effect of oxymatrine on quartz-induced secretion of TNF-alpha by the pulmonary_alveolar_macrophages in the fibroblast proliferation .
23754270	0	oxymatrine	26,36	VEGF	94,98	oxymatrine	VEGF	MESH:C037573	7422	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Antiangiogenic effects of oxymatrine on pancreatic_cancer by inhibition of the NF-kB-mediated VEGF signaling pathway .
19567170	0	oxymatrine	10,20	p38	28,31	oxymatrine	p38	MESH:C037573	81649(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|protein protein|amod|END_ENTITY	Effect of oxymatrine on the p38 mitogen-activated protein kinases signalling pathway in rats with CCl4 induced hepatic fibrosis .
9442826	0	oxymetazoline	15,28	lysozyme	32,40	oxymetazoline	lysozyme	MESH:D010109	4069	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|secretion secretion|amod|END_ENTITY	The effects of oxymetazoline on lysozyme secretion from the human nasal mucosa .
21084036	0	oxymetholone	16,28	erythropoietin	49,63	oxymetholone	erythropoietin	MESH:D010110	2056	Chemical	Gene	efficacy|nmod|START_ENTITY efficacy|nmod|END_ENTITY	The efficacy of oxymetholone in combination with erythropoietin on hematologic parameters and muscle mass in CAPD patients .
18676367	0	oxysterol	41,50	LXRalpha	61,69	oxysterol	LXRalpha	CHEBI:53030	10062	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Regulation of cholesterologenesis by the oxysterol receptor , LXRalpha .
9874807	0	oxysterol	43,52	LXRalpha	71,79	oxysterol	LXRalpha	CHEBI:53030	10062	Chemical	Gene	liver|amod|START_ENTITY ligands|nmod|liver requirements|nmod|ligands requirements|dep|END_ENTITY	Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta .
11562371	0	oxysterol	40,49	lipoprotein_lipase	14,32	oxysterol	lipoprotein lipase	CHEBI:53030	16956(Tax:10090)	Chemical	Gene	receptors|amod|START_ENTITY Regulation|nmod|receptors Regulation|nmod|END_ENTITY	Regulation of lipoprotein_lipase by the oxysterol receptors , LXRalpha and LXRbeta .
11521968	0	oxysterol	17,26	sterol_27-hydroxylase	50,71	oxysterol	sterol 27-hydroxylase	CHEBI:53030	1593	Chemical	Gene	Metabolism|nmod|START_ENTITY Metabolism|nmod|END_ENTITY	Metabolism of an oxysterol , 7-ketocholesterol , by sterol_27-hydroxylase in HepG2 cells .
11606068	0	oxysterols	37,47	ABCG4	10,15	oxysterols	ABCG4	CHEBI:53030	64137	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|gene gene|compound|END_ENTITY	The human ABCG4 gene is regulated by oxysterols and retinoids in monocyte-derived macrophages .
20416362	0	oxysterols	47,57	APOE	14,18	oxysterols	APOE	CHEBI:53030	348	Chemical	Gene	levels|nmod|START_ENTITY genotype|nmod|levels genotype|nsubj|effect effect|nmod|END_ENTITY	The effect of APOE genotype on brain levels of oxysterols in young and old human APOE epsilon2 , epsilon3 and epsilon4 knock-in mice .
20416362	0	oxysterols	47,57	APOE	81,85	oxysterols	APOE	CHEBI:53030	11816(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	The effect of APOE genotype on brain levels of oxysterols in young and old human APOE epsilon2 , epsilon3 and epsilon4 knock-in mice .
20299684	0	oxysterols	93,103	Apoe	137,141	oxysterols	Apoe	CHEBI:53030	11816(Tax:10090)	Chemical	Gene	Abcg1|nmod|START_ENTITY Impaired|nmod|Abcg1 Impaired|ccomp|accumulate accumulate|nmod|Abcg1 Abcg1|dep|END_ENTITY	Impaired development of atherosclerosis in Abcg1 - / - Apoe - / - mice : identification of specific oxysterols that both accumulate in Abcg1 - / - Apoe - / - tissues and induce apoptosis .
20299684	0	oxysterols	93,103	Apoe	52,56	oxysterols	Apoe	CHEBI:53030	11816(Tax:10090)	Chemical	Gene	Abcg1|nmod|START_ENTITY Abcg1|dep|END_ENTITY	Impaired development of atherosclerosis in Abcg1 - / - Apoe - / - mice : identification of specific oxysterols that both accumulate in Abcg1 - / - Apoe - / - tissues and induce apoptosis .
25765595	0	oxysterols	20,30	apoE	54,58	oxysterols	apoE	CHEBI:53030	11816(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Vascular effects of oxysterols and oxyphytosterols in apoE - / - mice .
15077693	0	oxytetracycline	20,35	matrix_metalloproteinase-1	39,65	oxytetracycline	matrix metalloproteinase-1	MESH:D010118	100034145(Tax:9796)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	In vitro effects of oxytetracycline on matrix_metalloproteinase-1 mRNA expression and on collagen gel contraction by cultured myofibroblasts obtained from the accessory ligament of foals .
16088947	0	oxytocin	131,139	5-HT2A	91,97	oxytocin	5-HT2A	MESH:D010121	29595(Tax:10116)	Chemical	Gene	stimulation|nmod|START_ENTITY stimulation|amod|END_ENTITY	Fluoxetine treatment of prepubescent rats produces a selective functional reduction in the 5-HT2A receptor-mediated stimulation of oxytocin .
14614094	0	oxytocin	48,56	Alpha-melanocyte-stimulating_hormone	0,36	oxytocin	Alpha-melanocyte-stimulating hormone	MESH:D010121	5443	Chemical	Gene	release|compound|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Alpha-melanocyte-stimulating_hormone stimulates oxytocin release from the dendrites of hypothalamic neurons while inhibiting oxytocin release from their terminals in the neurohypophysis .
10859491	0	oxytocin	52,60	C-fos	14,19	oxytocin	C-fos	MESH:D010121	314322(Tax:10116)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|protein protein|compound|END_ENTITY	Regulation of C-fos protein in gonadotrope cells by oxytocin and gonadotropin-releasing_hormone .
19215523	0	oxytocin	59,67	C-fos	26,31	oxytocin	C-fos	MESH:D010121	2353	Chemical	Gene	activates|nmod|START_ENTITY activates|dobj|expression expression|compound|END_ENTITY	Cholecystokinin activates C-fos expression in hypothalamic oxytocin and corticotropin-releasing_hormone neurons .
24790515	0	oxytocin	98,106	C-reactive_protein	19,37	oxytocin	C-reactive protein	MESH:D010121	1401	Chemical	Gene	predict|nmod|START_ENTITY predict|nsubj|levels levels|amod|END_ENTITY	Can maternal serum C-reactive_protein levels predict successful labour induction with intravenous oxytocin in term pregnancies complicated with premature_rupture_of_the_membranes ?
17688286	0	oxytocin	15,23	CD38	0,4	oxytocin	CD38	MESH:D010121	952	Chemical	Gene	secretion|compound|START_ENTITY regulates|dobj|secretion regulates|nsubj|END_ENTITY	CD38 regulates oxytocin secretion and complex social behavior .
9574845	0	oxytocin	16,24	CRF	46,49	oxytocin	CRF	MESH:D010121	81648(Tax:10116)	Chemical	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of oxytocin and vasopressin with CRF on the rat colon .
26344333	0	oxytocin	93,101	DYNLL2	52,58	oxytocin	DYNLL2	MESH:D010121	140735	Chemical	Gene	neurons|compound|START_ENTITY END_ENTITY|nmod|neurons	Fasted/fed states regulate postsynaptic hub protein DYNLL2 and glutamatergic transmission in oxytocin neurons in the hypothalamic paraventricular nucleus .
6722545	0	oxytocin	59,67	Enkephalin	0,10	oxytocin	Enkephalin	MESH:D010121	29237(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Enkephalin inhibition of angiotensin-stimulated release of oxytocin and vasopressin .
8255396	0	oxytocin	37,45	FOS	13,16	oxytocin	FOS	MESH:D010121	314322(Tax:10116)	Chemical	Gene	neurons|compound|START_ENTITY immunoreactivity|nmod|neurons immunoreactivity|nsubj|Induction Induction|nmod|END_ENTITY	Induction of FOS immunoreactivity in oxytocin neurons after sexual activity in female rats .
15176441	0	oxytocin	37,45	Fos	13,16	oxytocin	Fos	MESH:D010121	314322(Tax:10116)	Chemical	Gene	neurons|compound|START_ENTITY Induction|nmod|neurons Induction|nmod|immunoreactivity immunoreactivity|compound|END_ENTITY	Induction of Fos immunoreactivity in oxytocin neurons in the paraventricular nucleus after female odor exposure in male rats : effects of sexual experience .
15177879	0	oxytocin	57,65	Fos	13,16	oxytocin	Fos	MESH:D010121	314322(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	TFF3 induced Fos protein expression in the magnocellular oxytocin neurons of the hypothalamus .
18955037	0	oxytocin	52,60	Fos	34,37	oxytocin	Fos	MESH:D010121	314322(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Proximal_colon_distension induces Fos expression in oxytocin - , vasopressin - , CRF - and catecholamines-containing neurons in rat brain .
23363338	8	oxytocin	1027,1035	Fos	1012,1015	oxytocin	CCK	MESH:D010121	12424(Tax:10090)	Chemical	Gene	neurones|compound|START_ENTITY protein|nmod|neurones protein|compound|END_ENTITY	The increased expression of Fos protein in oxytocin neurones following re-feeding or i.p. administration of cholecystokinin_octapeptide -LRB- CCK -RRB- , a peripheral satiety factor , was impaired_in_PrRP-deficient mice .
24012945	0	oxytocin	11,19	Fos	50,53	oxytocin	Fos	MESH:D010121	101831721	Chemical	Gene	necessary|nsubj|START_ENTITY necessary|nmod|expression expression|compound|END_ENTITY	Endogenous oxytocin is necessary for preferential Fos expression to male odors in the bed nucleus of the stria terminalis in female Syrian_hamsters .
8025564	0	oxytocin	28,36	Fos	10,13	oxytocin	Fos	MESH:D010121	314322(Tax:10116)	Chemical	Gene	neurons|compound|START_ENTITY expression|nmod|neurons expression|compound|END_ENTITY	Increased Fos expression in oxytocin neurons following masculine sexual_behavior .
8782874	0	oxytocin	26,34	Fos	134,137	oxytocin	Fos	MESH:D010121	314322(Tax:10116)	Chemical	Gene	responses|nmod|START_ENTITY neurons|nsubj|responses neurons|parataxis|double double|nsubj|protein protein|compound|END_ENTITY	Differential responses of oxytocin and vasopressin neurons to the osmotic and stressful components of hypertonic saline injections : a Fos protein double labeling study .
15706228	0	oxytocin	45,53	Galanin-like_peptide	0,20	oxytocin	Galanin-like peptide	MESH:D010121	64568(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Galanin-like_peptide stimulates vasopressin , oxytocin and adrenocorticotropic hormone release in rats .
17504438	0	oxytocin	130,138	GnRH	142,146	oxytocin	GnRH	MESH:D010121	25194(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|neurones neurones|compound|END_ENTITY	Presence of oxytocin receptors in the gonadotrophin-releasing_hormone -LRB- GnRH -RRB- neurones in female rats : a possible direct action of oxytocin on GnRH neurones .
3257517	0	oxytocin	40,48	Insulin-like_growth_factor-I	0,28	oxytocin	Insulin-like growth factor-I	MESH:D010121	104978413	Chemical	Gene	production|compound|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Insulin-like_growth_factor-I stimulates oxytocin and progesterone production by bovine granulosa cells in culture .
14561937	0	oxytocin	25,33	Neuromedin_U	0,12	oxytocin	Neuromedin U	MESH:D010121	63887(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY facilitates|dobj|release facilitates|nsubj|END_ENTITY	Neuromedin_U facilitates oxytocin release from the pituitary via beta adrenoceptors .
20488544	0	oxytocin	24,32	OXTR	48,52	oxytocin	OXTR	MESH:D010121	5021	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The association between oxytocin receptor gene -LRB- OXTR -RRB- polymorphisms and affective temperaments , as measured by TEMPS-A .
26178189	0	oxytocin	73,81	OXTR	33,37	oxytocin	OXTR	MESH:D010121	5021	Chemical	Gene	effects|compound|START_ENTITY modulates|dobj|effects modulates|nsubj|polymorphism polymorphism|appos|END_ENTITY	A common oxytocin_receptor gene -LRB- OXTR -RRB- polymorphism modulates intranasal oxytocin effects on the neural response to social cooperation in humans .
15990679	0	oxytocin	63,71	Placental_leucine_aminopeptidase	0,32	oxytocin	Placental leucine aminopeptidase	MESH:D010121	4012	Chemical	Gene	effects|nmod|START_ENTITY regulate|dobj|effects regulate|nsubj|END_ENTITY	Placental_leucine_aminopeptidase might regulate the effects of oxytocin with resolution in endothelial cells .
1883415	0	oxytocin	36,44	Prolactin	0,9	oxytocin	Prolactin	MESH:D010121	24683(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Prolactin stimulates the release of oxytocin in lactating rats : evidence for a physiological role via an action at the neural lobe .
20943859	0	oxytocin	19,27	Prolactin	0,9	oxytocin	Prolactin	MESH:D010121	24683(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY promotes|dobj|release promotes|nsubj|END_ENTITY	Prolactin promotes oxytocin and vasopressin release by activating neuronal nitric_oxide synthase in the supraoptic and paraventricular nuclei .
15177879	0	oxytocin	57,65	TFF3	0,4	oxytocin	TFF3	MESH:D010121	25563(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	TFF3 induced Fos protein expression in the magnocellular oxytocin neurons of the hypothalamus .
7976418	1	oxytocin	74,82	VIP	95,98	oxytocin	VIP	MESH:D010121	117064(Tax:10116)	Chemical	Gene	glucagon|compound|START_ENTITY glucagon|dep|END_ENTITY	Effects on plasma levels of oxytocin , prolactin , VIP , somatostatin , insulin , glucagon , glucose and of milk secretion in lactating rats .
12855184	0	oxytocin	100,108	c-Fos	22,27	oxytocin	c-Fos	MESH:D010121	2353	Chemical	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Central expression of c-Fos in neonatal male and female prairie voles in response to treatment with oxytocin .
22420322	0	oxytocin	15,23	c-Fos	118,123	oxytocin	c-Fos	MESH:D010121	314322(Tax:10116)	Chemical	Gene	agonist|compound|START_ENTITY agonist|nmod|expression expression|amod|END_ENTITY	The nonpeptide oxytocin receptor agonist WAY_267 ,464 : receptor-binding profile , prosocial effects and distribution of c-Fos expression in adolescent rats .
25038444	0	oxytocin	14,22	c-Fos	126,131	oxytocin	c-Fos	MESH:D010121	14281(Tax:10090)	Chemical	Gene	agonist|compound|START_ENTITY alleviates|nsubj|agonist alleviates|parataxis|insights insights|nmod|changes changes|nmod|immunoreactivity immunoreactivity|amod|END_ENTITY	A non-peptide oxytocin receptor agonist , WAY-267 ,464 , alleviates novelty-induced hypophagia in mice : insights into changes in c-Fos immunoreactivity .
1393570	0	oxytocin	64,72	c-fos	14,19	oxytocin	c-fos	MESH:D010121	314322(Tax:10116)	Chemical	Gene	neurons|amod|START_ENTITY protein|nmod|neurons protein|amod|END_ENTITY	Expression of c-fos protein by immunohistochemically identified oxytocin neurons in the rat hypothalamus upon osmotic stimulation .
7828526	0	oxytocin	35,43	c-fos	95,100	oxytocin	c-fos	MESH:D010121	314322(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY Induction|nmod|activity replicates|nsubj|Induction replicates|ccomp|stem stem|nsubj|expression expression|nmod|END_ENTITY	Induction of uterine activity with oxytocin in late pregnant rats replicates the expression of c-fos in neuroendocrine and brain stem neurons as seen during parturition .
8275963	0	oxytocin	68,76	c-fos	21,26	oxytocin	c-fos	MESH:D010121	2353	Chemical	Gene	stimulates|dep|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Histamine stimulates c-fos expression in hypothalamic vasopressin - , _ oxytocin - , _ and_corticotropin-releasing_hormone-containing neurons .
6099511	0	oxytocin	14,22	enkephalin	68,78	oxytocin	enkephalin	MESH:D010121	29237(Tax:10116)	Chemical	Gene	Inhibition|nmod|START_ENTITY secretion|nsubj|Inhibition secretion|nmod|analogues analogues|compound|END_ENTITY	Inhibition of oxytocin secretion by mu and delta receptor selective enkephalin analogues .
11442774	0	oxytocin	114,122	fos	46,49	oxytocin	fos	MESH:D010121	314322(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of nitric_oxide synthase inhibition on fos expression in the hypothalamus of female rats following central oxytocin and systemic urethane administration .
7716067	0	oxytocin	29,37	gonadotropin-releasing_hormone	58,88	oxytocin	gonadotropin-releasing hormone	MESH:D010121	25194(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of administration of oxytocin in association with gonadotropin-releasing_hormone on luteinizing hormone levels in rats in vivo .
8788308	0	oxytocin	120,128	growth_hormone	104,118	oxytocin	growth hormone	MESH:D010121	2688	Chemical	Gene	steroids|dep|START_ENTITY steroids|compound|END_ENTITY	The release of insulin-like_growth_factor-I by luteinized human granulosa cells in vitro : regulation by growth_hormone , oxytocin , steroids and cAMP-dependent intracellular mechanisms .
8958575	0	oxytocin	10,18	growth_hormone	22,36	oxytocin	growth hormone	MESH:D010121	81668(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|release release|amod|END_ENTITY	Effect of oxytocin on growth_hormone release in vitro .
22060896	0	oxytocin	82,90	heme_oxygenase-1	23,39	oxytocin	heme oxygenase-1	MESH:D010121	24451(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|amod|END_ENTITY	Enhanced expression of heme_oxygenase-1 and carbon_monoxide excitatory effects in oxytocin and vasopressin neurones during water_deprivation .
2395821	0	oxytocin	52,60	interleukin-1_beta	13,31	oxytocin	interleukin-1 beta	MESH:D010121	24494(Tax:10116)	Chemical	Gene	secretion|nmod|START_ENTITY END_ENTITY|nmod|secretion	Influence of interleukin-1_beta on the secretion of oxytocin and vasopressin from the isolated rat neurohypophysis .
9139116	0	oxytocin	40,48	neurophysin_I	26,39	oxytocin	neurophysin I	MESH:D010121	5020	Chemical	Gene	complex|compound|START_ENTITY complex|amod|END_ENTITY	Molecular modeling of the neurophysin_I / oxytocin complex .
932015	0	oxytocin	16,24	neurophysins_I_and_II	53,74	oxytocin	neurophysins I and II	MESH:D010121	280728(Tax:9913)	Chemical	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of oxytocin and vasopressin with bovine neurophysins_I_and_II .
10026797	0	oxytocin	73,81	nociceptin	22,32	oxytocin	nociceptin	MESH:D010121	25516(Tax:10116)	Chemical	Gene	actions|nmod|START_ENTITY actions|nmod|END_ENTITY	Inhibitory actions of nociceptin -LRB- orphanin_FQ -RRB- on rat supraoptic nucleus oxytocin and vasopressin neurones in vitro .
7069260	0	oxytocin	16,24	placental_leucine_aminopeptidase	47,79	oxytocin	placental leucine aminopeptidase	MESH:D010121	4012	Chemical	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of oxytocin and angiotensin_II by placental_leucine_aminopeptidase -LRB- P-LAP -RRB- .
10612638	0	oxytocin	65,73	prolactin-releasing_peptide	26,53	oxytocin	prolactin-releasing peptide	MESH:D010121	63850(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|administration administration|nmod|stimulates stimulates|amod|END_ENTITY	Central administration of prolactin-releasing_peptide stimulates oxytocin release in rats .
16410399	0	oxytocin	71,79	prolactin_receptor	35,53	oxytocin	prolactin receptor	MESH:D010121	24684(Tax:10116)	Chemical	Gene	neurons|compound|START_ENTITY END_ENTITY|nmod|neurons	Expression of the long form of the prolactin_receptor in magnocellular oxytocin neurons is associated with specific prolactin regulation of oxytocin neurons .
3892979	0	oxytocin	11,19	renin	23,28	oxytocin	renin	MESH:D010121	5972	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	-LSB- Effect of oxytocin on renin activity and aldosterone concentration in plasma as well as blood pressure in late pregnancy and early puerperium -RSB- .
20332196	0	oxytocin	50,58	secretin	12,20	oxytocin	secretin	MESH:D010121	24769(Tax:10116)	Chemical	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Circulating secretin activates supraoptic nucleus oxytocin and vasopressin neurons via noradrenergic pathways in the rat .
7976418	1	oxytocin	74,82	somatostatin	100,112	oxytocin	somatostatin	MESH:D010121	24797(Tax:10116)	Chemical	Gene	glucagon|compound|START_ENTITY glucagon|dep|END_ENTITY	Effects on plasma levels of oxytocin , prolactin , VIP , somatostatin , insulin , glucagon , glucose and of milk secretion in lactating rats .
11500247	0	oxytocin	21,29	vasopressin	70,81	oxytocin	vasopressin	MESH:D010121	551	Chemical	Gene	effect|nmod|START_ENTITY effect|parataxis|END_ENTITY	Inhibitory effect of oxytocin on corticotrope function in humans : are vasopressin and oxytocin ying-yang neurohormones ?
7200230	0	oxytocin	35,43	vasopressin	20,31	oxytocin	vasopressin	MESH:D010121	396995(Tax:9823)	Chemical	Gene	effects|dep|START_ENTITY effects|nmod|END_ENTITY	Vascular effects of vasopressin an oxytocin in the pig mesenteric bed .
22564436	0	oxytoxin	94,102	Connexin43	69,79	oxytoxin	Connexin43	null	14609(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Mechanism of PKA-dependent and lipid-raft independent stimulation of Connexin43 expression by oxytoxin in mouse embryonic stem cells .
19507014	0	ozagrel	19,26	tyrosinase	39,49	ozagrel	tyrosinase	MESH:C034364	7299	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nsubj|effect	In vitro effect of ozagrel on mushroom tyrosinase .
9028799	0	ozone	24,29	Clara_cell_secretory_protein	42,70	ozone	Clara cell secretory protein	MESH:D010126	25575(Tax:10116)	Chemical	Gene	exposure|compound|START_ENTITY exposure|nmod|expression expression|compound|END_ENTITY	Effect of chronic daily ozone exposure on Clara_cell_secretory_protein mRNA expression in the adult rat lung .
24613443	0	ozone	24,29	Cleaning-in-Place	34,51	ozone	Cleaning-in-Place	MESH:D010126	102157402	Chemical	Gene	using|dobj|START_ENTITY using|nmod|END_ENTITY	A green procedure using ozone for Cleaning-in-Place in the beverage industry .
16870661	0	ozone	72,77	GSTM1	0,5	ozone	GSTM1	MESH:D010126	2944	Chemical	Gene	exposed|nmod|START_ENTITY exposed|nsubj|END_ENTITY	GSTM1 and GSTP1 and respiratory health in asthmatic children exposed to ozone .
19076539	0	ozone	51,56	IgE	12,15	ozone	IgE	MESH:D010126	3497	Chemical	Gene	concentration|compound|START_ENTITY associated|nmod|concentration associated|nsubjpass|levels levels|compound|END_ENTITY	Total serum IgE levels are associated with ambient ozone concentration in asthmatic adults .
22096575	0	ozone	66,71	SERCA2	0,6	ozone	SERCA2	MESH:D010126	488	Chemical	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	SERCA2 regulates non-CF and CF airway epithelial cell response to ozone .
21690068	0	ozone	27,32	TNF-a	65,70	ozone	TNF-a	MESH:D010126	24835(Tax:10116)	Chemical	Gene	injection|compound|START_ENTITY injection|nmod|TNFR_I TNFR_I|nummod|END_ENTITY	-LSB- Effect of intra-articular ozone injection on serum and synovial TNF-a , TNFR_I , and TNFR_II contents in rats with rheumatoid_arthritis -RSB- .
23052485	0	ozone	71,76	TNF-a	93,98	ozone	TNF-a	MESH:D010126	103694380	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of intra-articular injection of different concentrations of ozone on the level of TNF-a , TNF-R1 , and TNF-R2 in rats with rheumatoid_arthritis .
21690068	0	ozone	27,32	TNFR_I	72,78	ozone	TNFR I	MESH:D010126	25625(Tax:10116)	Chemical	Gene	injection|compound|START_ENTITY injection|nmod|END_ENTITY	-LSB- Effect of intra-articular ozone injection on serum and synovial TNF-a , TNFR_I , and TNFR_II contents in rats with rheumatoid_arthritis -RSB- .
9389172	0	ozone	104,109	epidermal_growth_factor	26,49	ozone	epidermal growth factor	MESH:D010126	100008808(Tax:9986)	Chemical	Gene	-RSB-|compound|START_ENTITY exposed|nmod|-RSB- exposed|nsubj|effect effect|nmod|END_ENTITY	-LSB- Cytoprotective effect of epidermal_growth_factor on cultured rabbit airway epithelial cells exposed to ozone -RSB- .
14713916	0	ozone	89,94	epidermal_growth_factor_receptor	17,49	ozone	epidermal growth factor receptor	MESH:D010126	1956	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of the epidermal_growth_factor_receptor and its ligands in nasal epithelium by ozone .
3916973	0	ozone	79,84	glucose_6-phosphate_dehydrogenase	22,55	ozone	glucose 6-phosphate dehydrogenase	MESH:D010126	2539	Chemical	Gene	cells|nmod|START_ENTITY cells|amod|END_ENTITY	Estimation of risk of glucose_6-phosphate_dehydrogenase deficient red cells to ozone and nitrogen_dioxide .
6703696	0	ozone	16,21	glyceraldehyde-3-phosphate_dehydrogenase	27,67	ozone	glyceraldehyde-3-phosphate dehydrogenase	MESH:D010126	2597	Chemical	Gene	reaction|nmod|START_ENTITY reaction|nmod|END_ENTITY	The reaction of ozone with glyceraldehyde-3-phosphate_dehydrogenase .
15516495	0	ozone	52,57	interleukin-6	8,21	ozone	interleukin-6	MESH:D010126	16193(Tax:10090)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of interleukin-6 in murine airway responses to ozone .
8727540	0	ozone	60,65	surfactant_protein_A	15,35	ozone	surfactant protein A	MESH:D010126	100135615(Tax:10141)	Chemical	Gene	Alterations|nmod|START_ENTITY Alterations|nmod|END_ENTITY	Alterations in surfactant_protein_A after acute exposure to ozone .
9175234	0	p-Aminobenzoic_acid	0,19	thrombin	78,86	p-Aminobenzoic acid	thrombin	MESH:D010129	2147	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	p-Aminobenzoic_acid , but not its metabolite p-acetamidobenzoic_acid , inhibits thrombin induced thromboxane formation in human platelets in a non NSAID like manner .
234440	0	p-Chlorphenylalanine	0,20	phenylalanine_hydroxylase	31,56	p-Chlorphenylalanine	phenylalanine hydroxylase	null	5053	Chemical	Gene	effect|amod|START_ENTITY effect|nmod|END_ENTITY	p-Chlorphenylalanine effect on phenylalanine_hydroxylase in hepatoma cells in culture .
25954129	0	p-Coumaric_Acid	0,15	Stratifin	50,59	p-Coumaric Acid	Stratifin	MESH:C032171	2810	Chemical	Gene	Release|amod|START_ENTITY Release|nmod|END_ENTITY	p-Coumaric_Acid Attenuates UVB-Induced Release of Stratifin from Keratinocytes and Indirectly Regulates Matrix_Metalloproteinase_1 Release from Fibroblasts .
9085406	0	p-MPPI	27,33	5HT1A_receptor	43,57	p-MPPI	5HT1A receptor	MESH:C087205	15550(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Anxiolytic-like profile of p-MPPI , a novel 5HT1A_receptor antagonist , in the murine elevated plus-maze .
26627	0	p-Nitrobenzyl_p-toluenesulfonyl-L-arginine	0,42	thrombin	72,80	p-Nitrobenzyl p-toluenesulfonyl-L-arginine	thrombin	null	280685(Tax:9913)	Chemical	Gene	START_ENTITY|dep|substrate substrate|nmod|END_ENTITY	p-Nitrobenzyl_p-toluenesulfonyl-L-arginine : a chromogenic substrate for thrombin , plasmin and trypsin .
26180273	0	p-Nitrophenol	45,58	CYP2E1	72,78	p-Nitrophenol	CYP2E1	MESH:C024836	25086(Tax:10116)	Chemical	Gene	Activity|amod|START_ENTITY Activity|appos|END_ENTITY	Effect of Water Miscible Organic Solvents on p-Nitrophenol Hydroxylase -LRB- CYP2E1 -RRB- Activity in Rat Liver Microsomes .
24972725	0	p-aminophenols	10,24	tyrosinase	28,38	p-aminophenols	tyrosinase	null	7299	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	Effect of p-aminophenols on tyrosinase activity .
3861206	0	p-aminophenylalkylamines	83,107	monoamine_oxidase	14,31	p-aminophenylalkylamines	monoamine oxidase	null	29253(Tax:10116)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of monoamine_oxidase in 5-hydroxytryptaminergic neurones by substituted p-aminophenylalkylamines .
12659746	0	p-arylthio_cinnamides	19,40	ICAM-1	71,77	p-arylthio cinnamides	ICAM-1	null	3383	Chemical	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	QSAR study on some p-arylthio_cinnamides as antagonists of biochemical ICAM-1 / LFA-1 interaction and ICAM-1 / JY-8 cell adhesion in relation to anti-inflammatory activity .
10207608	0	p-bromophenacyl_bromide	28,51	Phospholipase_A2	0,16	p-bromophenacyl bromide	Phospholipase A2	MESH:C006821	18784(Tax:10090)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Phospholipase_A2 inhibitors p-bromophenacyl_bromide and arachidonyl_trifluoromethyl_ketone suppressed interleukin-2 -LRB- IL-2 -RRB- expression in murine primary splenocytes .
7882048	8	p-chloroamphetamine	1292,1311	oxytocin	1271,1279	p-chloroamphetamine	oxytocin	MESH:D010133	5020	Chemical	Gene	reduce|nmod|START_ENTITY reduce|dobj|response response|compound|END_ENTITY	In contrast , SON lesions did not alter basal oxytocin levels and did not reduce the oxytocin response to p-chloroamphetamine , suggesting that the SON is not involved in the serotonergic stimulation of oxytocin secretion .
180005	0	p-chlorophenylalanine	58,79	phenylalanine_hydroxylase	29,54	p-chlorophenylalanine	phenylalanine hydroxylase	null	24616(Tax:10116)	Chemical	Gene	Mechanism|nmod|START_ENTITY Mechanism|nmod|END_ENTITY	Mechanism of inactivation of phenylalanine_hydroxylase by p-chlorophenylalanine in hepatome cells in culture .
11456281	0	p-chlorophenylalanine	33,54	prolactin	64,73	p-chlorophenylalanine	prolactin	null	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Effect of serotonin depletion by p-chlorophenylalanine on serum prolactin levels in estrogen-treated ovariectomized rats : insights concerning the serotoninergic , dopaminergic and opioid systems .
20077437	0	p-coumaric_acid	0,15	tyrosinase	40,50	p-coumaric acid	tyrosinase	MESH:C032171	7299	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	p-coumaric_acid not only inhibits human tyrosinase activity in vitro but also melanogenesis in cells exposed to UVB .
24410493	0	p-cresol	146,154	OBP	117,120	p-cresol	OBP	MESH:C032538	505052(Tax:9913)	Chemical	Gene	analysis|nmod|START_ENTITY analysis|nmod|END_ENTITY	Identification of p-cresol as an estrus-specific volatile in buffalo saliva : comparative docking analysis of buffalo OBP and b-lactoglobulin with p-cresol .
10800950	0	p-ethynylphenylalanine	0,22	tryptophan_hydroxylase	46,68	p-ethynylphenylalanine	tryptophan hydroxylase	null	24848(Tax:10116)	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	p-ethynylphenylalanine : a potent inhibitor of tryptophan_hydroxylase .
17541167	0	p-hydroxybenzyl_alcohol	21,44	tyrosinase	48,58	p-hydroxybenzyl alcohol	tyrosinase	MESH:C018966	22173(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|amod|END_ENTITY	Inhibitory effect of p-hydroxybenzyl_alcohol on tyrosinase activity and melanogenesis .
25913862	0	p-hydroxybenzyl_alcohol	18,41	tyrosinase	93,103	p-hydroxybenzyl alcohol	tyrosinase	MESH:C018966	7299	Chemical	Gene	phloretin|dep|START_ENTITY phloridzin|amod|phloretin Identification|nmod|phloridzin Identification|nmod|substrates substrates|amod|END_ENTITY	Identification of p-hydroxybenzyl_alcohol , tyrosol , phloretin and its derivate phloridzin as tyrosinase substrates .
25913862	0	p-hydroxybenzyl_alcohol	18,41	tyrosinase	93,103	p-hydroxybenzyl alcohol	tyrosinase	MESH:C018966	7299	Chemical	Gene	phloretin|dep|START_ENTITY phloridzin|amod|phloretin Identification|nmod|phloridzin Identification|nmod|substrates substrates|amod|END_ENTITY	Identification of p-hydroxybenzyl_alcohol , tyrosol , phloretin and its derivate phloridzin as tyrosinase substrates .
10622704	0	p-hydroxyphenylpyruvate	31,54	transketolase	14,27	p-hydroxyphenylpyruvate	transketolase	MESH:C010590	7086	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of transketolase by p-hydroxyphenylpyruvate .
6811575	0	p-nitroanisole	47,61	cytochrome_b5	22,35	p-nitroanisole	cytochrome b5	MESH:C005306	64001(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|effect effect|nmod|END_ENTITY	Stimulatory effect of cytochrome_b5 induced by p-nitroanisole and diisopropyl_1 ,3 - dithiol-2-ylidenemalonate on rat liver microsomal drug hydroxylations .
15135088	0	p-nitrophenol	55,68	CYP2E1	101,107	p-nitrophenol	CYP2E1	MESH:C024836	1571	Chemical	Gene	hydroxylation|amod|START_ENTITY participating|nmod|hydroxylation enzymes|acl|participating Inhibition|nmod|enzymes known|nsubj|Inhibition known|nmod|inhibitors inhibitors|nummod|END_ENTITY	Inhibition of cytochrome P450 enzymes participating in p-nitrophenol hydroxylation by drugs known as CYP2E1 inhibitors .
15205381	0	p-nitrophenol	47,60	CYP2E1	14,20	p-nitrophenol	CYP2E1	MESH:C024836	13106(Tax:10090)	Chemical	Gene	O-hydroxylation|nmod|START_ENTITY END_ENTITY|nmod|O-hydroxylation	Role of mouse CYP2E1 in the O-hydroxylation of p-nitrophenol : comparison of activities in hepatic microsomes from Cyp2e1 -LRB- - / - -RRB- and wild-type mice .
15205381	0	p-nitrophenol	47,60	Cyp2e1	114,120	p-nitrophenol	Cyp2e1	MESH:C024836	13106(Tax:10090)	Chemical	Gene	O-hydroxylation|nmod|START_ENTITY CYP2E1|nmod|O-hydroxylation Role|nmod|CYP2E1 Role|dep|comparison comparison|nmod|activities activities|nmod|microsomes microsomes|nmod|END_ENTITY	Role of mouse CYP2E1 in the O-hydroxylation of p-nitrophenol : comparison of activities in hepatic microsomes from Cyp2e1 -LRB- - / - -RRB- and wild-type mice .
6253559	0	p-nitrophenyl	62,75	ATPase	99,105	p-nitrophenyl	ATPase	CHEBI:61595	1769	Chemical	Gene	phosphatase|amod|START_ENTITY phosphatase|appos|END_ENTITY	Cytochemical localization of ouabain-sensitive -LRB- K + -RRB- - dependent p-nitrophenyl phosphatase -LRB- transport ATPase -RRB- in human blood platelets .
2794798	0	p-nitrophenyl_butyrate	0,22	hormone-sensitive_lipase	47,71	p-nitrophenyl butyrate	hormone-sensitive lipase	MESH:C033592	286879(Tax:9913)	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	p-nitrophenyl_butyrate hydrolyzing activity of hormone-sensitive_lipase from bovine adipose tissue .
8118918	0	p-nitrophenyl_esters	19,39	C18	103,106	p-nitrophenyl esters	C18	null	27241	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	The effects of the p-nitrophenyl_esters of the even-numbered fatty_acids from caproic -LRB- C6 -RRB- to stearic -LRB- C18 -RRB- on the main phase transition of dimyristoylphosphatidylcholine .
3106018	0	p-tyramine	24,34	Prolactin	0,9	p-tyramine	Prolactin	MESH:D014439	24683(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Prolactin inhibition by p-tyramine in the male rat : site of action .
25955155	0	pGlcNAc	0,7	Akt1	124,128	pGlcNAc	Akt1	MESH:C113831	207	Chemical	Gene	Treatment|amod|START_ENTITY Treatment|nmod|END_ENTITY	pGlcNAc Nanofiber Treatment of Cutaneous Wounds Stimulate Increased Tensile Strength and Reduced Scarring via Activation of Akt1 .
7852885	0	pGlutamylglutamylprolineamide	0,29	growth_hormone	44,58	pGlutamylglutamylprolineamide	growth hormone	null	378781(Tax:9031)	Chemical	Gene	modulation|amod|START_ENTITY modulation|nmod|secretion secretion|amod|END_ENTITY	pGlutamylglutamylprolineamide modulation of growth_hormone secretion in domestic fowl : antagonism of thyrotrophin-releasing_hormone action ?
6439101	0	pO2	29,32	vasopressin	84,95	pO2	vasopressin	MESH:C093415	551	Chemical	Gene	START_ENTITY|nmod|infusion infusion|compound|END_ENTITY	Small bowel and liver tissue pO2 and pCO2 during hypovolaemic_shock and intravenous vasopressin infusion .
1587351	1	pachytene	110,119	bFGF	94,98	pachytene	bFGF	null	14173(Tax:10090)	Chemical	Gene	protein|nmod|START_ENTITY protein|compound|END_ENTITY	Presence of bFGF mRNA and of a 30 kDa bFGF protein in pachytene spermatocytes .
21059223	0	paclitaxel	58,68	Aurora-A	96,104	paclitaxel	Aurora-A	MESH:D017239	6790	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	ZNF217 confers resistance to the pro-apoptotic signals of paclitaxel and aberrant expression of Aurora-A in breast_cancer cells .
25912549	0	paclitaxel	60,70	BRAF	74,78	paclitaxel	BRAF	MESH:D017239	673	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Low inducible expression of p21 -LRB- Cip1 -RRB- confers resistance to paclitaxel in BRAF mutant melanoma cells with acquired resistance to BRAF inhibitor .
25374178	0	paclitaxel	86,96	Bax	19,22	paclitaxel	Bax	MESH:D017239	581	Chemical	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	Roles of the Bcl-2 / Bax ratio , caspase-8 and 9 in resistance of breast_cancer cells to paclitaxel .
20460378	0	paclitaxel	63,73	Bcl-2_antagonist_killer_1	111,136	paclitaxel	Bcl-2 antagonist killer 1	MESH:D017239	578;596	Chemical	Gene	START_ENTITY|nmod|suppression suppression|nmod|END_ENTITY	MicroRNA-125b confers the resistance of breast_cancer cells to paclitaxel through suppression of pro-apoptotic Bcl-2_antagonist_killer_1 -LRB- Bak1 -RRB- expression .
9218008	0	paclitaxel	10,20	CA_125	32,38	paclitaxel	CA 125	MESH:D017239	94025	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of paclitaxel -LRB- Taxol -RRB- on CA_125 expression and release by ovarian_cancer cell lines .
22416063	0	paclitaxel	85,95	CBT-1	57,62	paclitaxel	CBT-1	MESH:D017239	6392	Chemical	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	A pharmacodynamic study of the P-glycoprotein antagonist CBT-1 in combination with paclitaxel in solid tumors .
25516145	0	paclitaxel	69,79	CYP1B1	0,6	paclitaxel	CYP1B1	MESH:D017239	1545	Chemical	Gene	enhances|xcomp|START_ENTITY enhances|nsubj|END_ENTITY	CYP1B1 enhances the resistance of epithelial_ovarian_cancer cells to paclitaxel in vivo and in vitro .
15901749	0	paclitaxel	20,30	CYP2C8	87,93	paclitaxel	CYP2C8	MESH:D017239	1558	Chemical	Gene	Pharmacokinetics|nmod|START_ENTITY Pharmacokinetics|nmod|END_ENTITY	Pharmacokinetics of paclitaxel in ovarian_cancer patients and genetic polymorphisms of CYP2C8 , CYP3A4 , and MDR1 .
16533873	0	paclitaxel	140,150	EGFR	83,87	paclitaxel	EGFR	MESH:D017239	1956	Chemical	Gene	EMD|nmod|START_ENTITY EMD|nsubj|study study|nmod|antibody antibody|appos|END_ENTITY	A phase I study of the humanized monoclonal anti-epidermal_growth_factor_receptor -LRB- EGFR -RRB- antibody EMD 72000 -LRB- matuzumab -RRB- in combination with paclitaxel in patients with EGFR-positive advanced non-small-cell_lung_cancer -LRB- NSCLC -RRB- .
18199556	0	paclitaxel	130,140	EGFR	108,112	paclitaxel	EGFR	MESH:D017239	1956	Chemical	Gene	expression|nmod|START_ENTITY expression|dobj|tumors tumors|amod|END_ENTITY	Inhibition of Hsp90 down-regulates mutant epidermal_growth_factor_receptor -LRB- EGFR -RRB- expression and sensitizes EGFR mutant tumors to paclitaxel .
18199556	0	paclitaxel	130,140	EGFR	76,80	paclitaxel	EGFR	MESH:D017239	1956	Chemical	Gene	expression|nmod|START_ENTITY expression|nsubj|Inhibition Inhibition|nmod|epidermal_growth_factor_receptor epidermal_growth_factor_receptor|appos|END_ENTITY	Inhibition of Hsp90 down-regulates mutant epidermal_growth_factor_receptor -LRB- EGFR -RRB- expression and sensitizes EGFR mutant tumors to paclitaxel .
23029028	0	paclitaxel	11,21	EGFR	25,29	paclitaxel	EGFR	MESH:D017239	1956	Chemical	Gene	START_ENTITY|nmod|trafficking trafficking|amod|END_ENTITY	Effects of paclitaxel on EGFR endocytic trafficking revealed using quantum dot tracking in single cells .
23879997	0	paclitaxel	46,56	EGFR	106,110	paclitaxel	EGFR	MESH:D017239	1956	Chemical	Gene	chemosensitization|acl|START_ENTITY mechanism|nmod|chemosensitization induced|nsubj|mechanism induced|advcl|targeting targeting|dobj|END_ENTITY	-LSB- Molecular mechanism of chemosensitization to paclitaxel in human melanoma cells induced by targeting the EGFR signaling pathway -RSB- .
24875132	0	paclitaxel	87,97	EGFR	14,18	paclitaxel	EGFR	MESH:D017239	1956	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of EGFR , HER2 and HER3 signaling with AZD8931 alone and in combination with paclitaxel : phase i study in Japanese patients with advanced solid malignancies and advanced_breast_cancer .
26799187	0	paclitaxel	42,52	EGFR	99,103	paclitaxel	EGFR	MESH:D017239	1956	Chemical	Gene	resistance|amod|START_ENTITY confers|dobj|resistance confers|nmod|regulation regulation|nmod|END_ENTITY	p38_MAPK-induced MDM2 degradation confers paclitaxel resistance through p53-mediated regulation of EGFR in human lung_cancer cells .
24376711	0	paclitaxel	13,23	ERa	38,41	paclitaxel	ERa	MESH:D017239	26284	Chemical	Gene	resistance|amod|START_ENTITY resistance|nmod|END_ENTITY	Induction of paclitaxel resistance by ERa mediated prohibitin mitochondrial-nuclear shuttling .
27067521	0	paclitaxel	51,61	Endostatin	20,30	paclitaxel	Endostatin	MESH:D017239	80781	Chemical	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	A phase II study of Endostatin in combination with paclitaxel , carboplatin , and radiotherapy in patients with unresectable locally advanced non-small_cell_lung_cancer .
21909982	0	paclitaxel	54,64	Estrogen_receptor-a	0,19	paclitaxel	Estrogen receptor-a	MESH:D017239	2099	Chemical	Gene	regulates|advcl|START_ENTITY regulates|nsubj|END_ENTITY	Estrogen_receptor-a directly regulates sensitivity to paclitaxel in neoadjuvant chemotherapy for breast_cancer .
17545614	0	paclitaxel	66,76	Estrogen_receptor_alpha	0,23	paclitaxel	Estrogen receptor alpha	MESH:D017239	2099	Chemical	Gene	mediates|xcomp|START_ENTITY mediates|nsubj|END_ENTITY	Estrogen_receptor_alpha mediates breast_cancer cell resistance to paclitaxel through inhibition of apoptotic cell death .
18319717	0	paclitaxel	76,86	FOXO1	19,24	paclitaxel	FOXO1	MESH:D017239	2308	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|involvement involvement|nmod|END_ENTITY	The involvement of FOXO1 in cytotoxic stress and drug-resistance induced by paclitaxel in ovarian_cancers .
19048624	0	paclitaxel	33,43	HB-EGF	73,79	paclitaxel	HB-EGF	MESH:D017239	1839	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|inhibitor inhibitor|nmod|END_ENTITY	Synergistic anti-tumor effect of paclitaxel with CRM197 , an inhibitor of HB-EGF , in ovarian_cancer .
11872285	0	paclitaxel	84,94	HER2/neu	4,12	paclitaxel	HER2/neu	MESH:D017239	2064	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|expression expression|amod|END_ENTITY	Low HER2/neu gene expression is associated with pathological response to concurrent paclitaxel and radiation therapy in locally advanced breast_cancer .
16731752	0	paclitaxel	16,26	HSP90	43,48	paclitaxel	HSP90	MESH:D017239	3320	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Potentiation of paclitaxel activity by the HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin in human ovarian_carcinoma cell lines with high levels of activated AKT .
15262123	0	paclitaxel	32,42	Kallikrein	0,10	paclitaxel	Kallikrein	MESH:D017239	9622	Chemical	Gene	resistance|amod|START_ENTITY associated|nmod|resistance associated|nsubjpass|END_ENTITY	Kallikrein 4 is associated with paclitaxel resistance in ovarian_cancer .
25756509	0	paclitaxel	54,64	MiR-1204	0,8	paclitaxel	MiR-1204	MESH:D017239	100302185	Chemical	Gene	sensitizes|xcomp|START_ENTITY sensitizes|nsubj|END_ENTITY	MiR-1204 sensitizes nasopharyngeal_carcinoma cells to paclitaxel both in vitro and in vivo .
26596839	0	paclitaxel	51,61	MyD88	24,29	paclitaxel	MyD88	MESH:D017239	4615	Chemical	Gene	resistance|amod|START_ENTITY END_ENTITY|nmod|resistance	Increased expression of MyD88 and association with paclitaxel resistance in breast_cancer .
19305429	0	paclitaxel	65,75	NAC-1	0,5	paclitaxel	NAC-1	MESH:D017239	112939	Chemical	Gene	contributes|xcomp|START_ENTITY contributes|nsubj|END_ENTITY	NAC-1 , a potential stem cell pluripotency factor , contributes to paclitaxel resistance in ovarian_cancer through inactivating Gadd45 pathway .
24252806	0	paclitaxel	120,130	P-glycoprotein	53,67	paclitaxel	P-glycoprotein	MESH:D017239	5243	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|inhibition inhibition|nmod|END_ENTITY	Effect of coumarin derivative-mediated inhibition of P-glycoprotein on oral bioavailability and therapeutic efficacy of paclitaxel .
12848775	0	paclitaxel	39,49	P-gp	77,81	paclitaxel	P-gp	MESH:D017239	283871	Chemical	Gene	model|nmod|START_ENTITY model|nmod|presence presence|nmod|modulator modulator|compound|END_ENTITY	A population pharmacokinetic model for paclitaxel in the presence of a novel P-gp modulator , Zosuquidar_Trihydrochloride -LRB- LY335979 -RRB- .
16713148	9	paclitaxel	1301,1311	P-gp	1388,1392	paclitaxel	P-gp	MESH:D017239	5243	Chemical	Gene	substrates|nmod|START_ENTITY susceptible|nsubj|substrates susceptible|xcomp|efflux efflux|nmod|END_ENTITY	In conclusion , our studies suggest that P-gp substrates , such as paclitaxel , delivered to MDR cells by PLGA nanoparticles , are susceptible to efflux by P-gp .
20438839	0	paclitaxel	63,73	P-gp	54,58	paclitaxel	P-gp	MESH:D017239	5243	Chemical	Gene	transport|amod|START_ENTITY END_ENTITY|nmod|transport	Reciprocal competition between lipid nanocapsules and P-gp for paclitaxel transport across Caco-2 cells .
21903258	0	paclitaxel	92,102	P-gp	71,75	paclitaxel	P-gp	MESH:D017239	5243	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Synergistic effect of folate-mediated targeting and verapamil-mediated P-gp inhibition with paclitaxel - polymer micelles to overcome multi-drug resistance .
24927684	0	paclitaxel	108,118	P-gp	60,64	paclitaxel	P-gp	MESH:D017239	283871	Chemical	Gene	delivery|nmod|START_ENTITY properties|nmod|delivery properties|compound|END_ENTITY	Amphiphilic carboxymethyl chitosan-quercetin conjugate with P-gp inhibitory properties for oral delivery of paclitaxel .
24956463	0	paclitaxel	90,100	P-gp	66,70	paclitaxel	P-gp	MESH:D017239	67078(Tax:10090)	Chemical	Gene	efflux|nmod|START_ENTITY efflux|compound|END_ENTITY	A novel approach to overcome multidrug resistance : utilization of P-gp mediated efflux of paclitaxel to attack neighboring vascular endothelial cells in tumors .
16739339	0	paclitaxel	102,112	P53	0,3	paclitaxel	P53	MESH:D017239	7157	Chemical	Gene	response|nmod|START_ENTITY relation|nmod|response serous_epithelial_ovarian_cancer|nmod|relation patients|nmod|serous_epithelial_ovarian_cancer status|nmod|patients status|compound|END_ENTITY	P53 gene status in patients with advanced serous_epithelial_ovarian_cancer in relation to response to paclitaxel - plus platinum-based chemotherapy and long-term clinical outcome .
25855930	0	paclitaxel	96,106	P53	57,60	paclitaxel	P53	MESH:D017239	7157	Chemical	Gene	HeLa|amod|START_ENTITY adenovirus|advcl|HeLa adenovirus|nsubj|effect effect|nmod|END_ENTITY	The mechanism and inhibitory effect of recombinant human P53 adenovirus injection combined with paclitaxel on human cervical_cancer cell HeLa .
23807572	0	paclitaxel	15,25	PI3K	41,45	paclitaxel	PI3K	MESH:D017239	5293	Chemical	Gene	resistance|amod|START_ENTITY resistance|nmod|END_ENTITY	Acquisition of paclitaxel resistance via PI3K - dependent epithelial - mesenchymal transition in A2780 human ovarian_cancer cells .
23479422	0	paclitaxel	26,36	RC0639	0,6	paclitaxel	RC0639	MESH:D017239	927723(Tax:272944)	Chemical	Gene	study|nmod|START_ENTITY END_ENTITY|dep|study	RC0639 : phase II study of paclitaxel , trastuzumab , and lapatinib as adjuvant therapy for early stage HER2-positive_breast_cancer .
16600800	0	paclitaxel	29,39	Rh2	0,3	paclitaxel	Rh2	MESH:D017239	6005	Chemical	Gene	enhances|xcomp|START_ENTITY enhances|nsubj|END_ENTITY	Rh2 synergistically enhances paclitaxel or mitoxantrone in prostate_cancer models .
25986856	0	paclitaxel	204,214	S-1	225,228	paclitaxel	S-1	MESH:D017239	5707	Chemical	Gene	treated|nmod|START_ENTITY treated|nmod|END_ENTITY	Cell-free and concentrated ascites reinfusion therapy -LRB- CART -RRB- for management of massive malignant_ascites in gastric_cancer patients with peritoneal metastasis treated with intravenous and intraperitoneal paclitaxel with oral S-1 .
25986856	0	paclitaxel	204,214	S-1	225,228	paclitaxel	S-1	MESH:D017239	5707	Chemical	Gene	treated|nmod|START_ENTITY treated|nmod|END_ENTITY	Cell-free and concentrated ascites reinfusion therapy -LRB- CART -RRB- for management of massive malignant_ascites in gastric_cancer patients with peritoneal metastasis treated with intravenous and intraperitoneal paclitaxel with oral S-1 .
23215690	0	paclitaxel	47,57	SLN	40,43	paclitaxel	SLN	MESH:D017239	6588	Chemical	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	2-Hydroxypropyl-b-cyclodextrin-modified SLN of paclitaxel for overcoming p-glycoprotein function in multidrug-resistant breast_cancer cells .
26878391	0	paclitaxel	18,28	STAT3	77,82	paclitaxel	STAT3	MESH:D017239	6774	Chemical	Gene	sensitivity|amod|START_ENTITY promotes|dobj|sensitivity promotes|advcl|altering altering|dobj|expression expression|compound|END_ENTITY	MiR-125a promotes paclitaxel sensitivity in cervical cancer through altering STAT3 expression .
24184484	0	paclitaxel	28,38	Six1	0,4	paclitaxel	Six1	MESH:D017239	6495	Chemical	Gene	mediates|advcl|START_ENTITY mediates|nsubj|END_ENTITY	Six1 mediates resistance to paclitaxel in breast_cancer cells .
22847181	0	paclitaxel	60,70	Stat3	74,79	paclitaxel	Stat3	MESH:D017239	6774	Chemical	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Mitochondrial uncoupling_protein_2 regulates the effects of paclitaxel on Stat3 activation and cellular survival in lung_cancer cells .
19148534	0	paclitaxel	44,54	TACC3	22,27	paclitaxel	TACC3	MESH:D017239	10460	Chemical	Gene	treatment|nmod|START_ENTITY effects|nmod|treatment effects|nmod|END_ENTITY	Anticancer effects on TACC3 by treatment of paclitaxel in HPV-18_positive_cervical_carcinoma cells .
18068629	0	paclitaxel	107,117	TGFBI	33,38	paclitaxel	TGFBI	MESH:D017239	7045	Chemical	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	The extracellular matrix protein TGFBI induces microtubule stabilization and sensitizes ovarian_cancers to paclitaxel .
22248469	0	paclitaxel	49,59	TGFBI	0,5	paclitaxel	TGFBI	MESH:D017239	7045	Chemical	Gene	chemoresistance|amod|START_ENTITY correlating|nmod|chemoresistance hypermethylation|xcomp|correlating hypermethylation|nsubj|promoter promoter|compound|END_ENTITY	TGFBI promoter hypermethylation correlating with paclitaxel chemoresistance in ovarian_cancer .
23441224	0	paclitaxel	24,34	TLR4	12,16	paclitaxel	TLR4	MESH:D017239	21898(Tax:10090)	Chemical	Gene	effects|amod|START_ENTITY role|nmod|effects role|nmod|END_ENTITY	The role of TLR4 in the paclitaxel effects on neuronal growth in vitro .
9588740	0	paclitaxel	46,56	activator_protein_1	14,33	paclitaxel	activator protein 1	MESH:D017239	280831(Tax:9913)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Inhibition of activator_protein_1 activity by paclitaxel suppresses interleukin-1-induced collagenase and stromelysin expression by bovine chondrocytes .
25313764	0	paclitaxel	82,92	caspase_3	102,111	paclitaxel	caspase 3	MESH:D017239	836	Chemical	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	A novel series of di-fluorinated_propanedione derivatives synergistically augment paclitaxel mediated caspase_3 activation in ovarian_cancer cells .
16053664	0	paclitaxel	82,92	cyclooxygenase-2	33,49	paclitaxel	cyclooxygenase-2	MESH:D017239	5743	Chemical	Gene	celecoxib|nmod|START_ENTITY celecoxib|amod|END_ENTITY	The combination of the selective cyclooxygenase-2 inhibitor celecoxib with weekly paclitaxel is a safe and active second-line therapy for non-small_cell_lung_cancer : a phase II study with biological correlates .
23420555	0	paclitaxel	59,69	erythropoietin	39,53	paclitaxel	erythropoietin	MESH:D017239	2056	Chemical	Gene	treatment|amod|START_ENTITY END_ENTITY|nmod|treatment	A potentially neuroprotective role for erythropoietin with paclitaxel treatment in ovarian_cancer patients : a prospective phase II GINECO trial .
17390065	0	paclitaxel	47,57	extracellular_signal-regulated_kinase	81,118	paclitaxel	extracellular signal-regulated kinase	MESH:D017239	5594	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	The growth inhibition of liver_cancer cells by paclitaxel and the involvement of extracellular_signal-regulated_kinase and apoptosis .
10091804	0	paclitaxel	17,27	granulocyte-colony_stimulating_factor	84,121	paclitaxel	granulocyte-colony stimulating factor	MESH:D017239	1440	Chemical	Gene	trial|nmod|START_ENTITY trial|appos|END_ENTITY	Phase I trial of paclitaxel , carboplatin , and topotecan with or without filgrastim -LRB- granulocyte-colony_stimulating_factor -RRB- in the treatment of patients with advanced , refractory_cancer .
10053098	0	paclitaxel	181,191	granulocyte_colony-stimulating_factor	133,170	paclitaxel	granulocyte colony-stimulating factor	MESH:D017239	1440	Chemical	Gene	chemotherapy|compound|START_ENTITY END_ENTITY|nmod|chemotherapy	A phase II double-blind randomized study of the simultaneous administration of recombinant human interleukin-6 and recombinant human granulocyte_colony-stimulating_factor following paclitaxel and carboplatin chemotherapy in patients with advanced_epithelial_ovarian_cancer .
8622023	0	paclitaxel	39,49	granulocyte_colony-stimulating_factor	71,108	paclitaxel	granulocyte colony-stimulating factor	MESH:D017239	1440	Chemical	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	Phase I/II study of 72-hour infusional paclitaxel and doxorubicin with granulocyte_colony-stimulating_factor in patients with metastatic breast_cancer .
19958621	0	paclitaxel	80,90	histone_deacetylase	36,55	paclitaxel	histone deacetylase	MESH:D017239	9734	Chemical	Gene	combined|nmod|START_ENTITY combined|nsubj|effect effect|nmod|inhibitor inhibitor|amod|END_ENTITY	-LSB- Synergistic cytotoxicity effect of histone_deacetylase inhibitor combined with paclitaxel on lung_cancer cell lines and its mechanism -RSB- .
21296416	1	paclitaxel	259,269	human	273,278	paclitaxel	BRCA1	MESH:D017239	672	Chemical	Gene	START_ENTITY|nmod|cells cells|amod|END_ENTITY	Both BRCA1 and CaSR have been shown to suppress the expression of survivin and promote sensitivity to paclitaxel in human breast_cancer cells .
23799854	0	paclitaxel	47,57	leukotriene_B4_receptor-2	2,27	paclitaxel	leukotriene B4 receptor-2	MESH:D017239	56413	Chemical	Gene	resistance|amod|START_ENTITY associated|nmod|resistance associated|nsubjpass|END_ENTITY	A leukotriene_B4_receptor-2 is associated with paclitaxel resistance in MCF-7 / DOX breast_cancer cells .
24137413	0	paclitaxel	17,27	miR-21	0,6	paclitaxel	miR-21	MESH:D017239	406991	Chemical	Gene	START_ENTITY|nsubj|modulates modulates|amod|END_ENTITY	miR-21 modulates paclitaxel sensitivity and hypoxia-inducible_factor-1a expression in human ovarian_cancer cells .
25973036	0	paclitaxel	36,46	miR-877	17,24	paclitaxel	miR-877	MESH:D017239	100126314	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Up-regulation of miR-877 induced by paclitaxel inhibits hepatocellular_carcinoma cell proliferation though targeting FOXM1 .
26144859	0	paclitaxel	72,82	p-gp	88,92	paclitaxel	p-gp	MESH:D017239	283871	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|amod|END_ENTITY	Novel dietary lipid-based self-nanoemulsifying drug delivery systems of paclitaxel with p-gp inhibitor : implications on cytotoxicity and biopharmaceutical performance .
25912549	0	paclitaxel	60,70	p21	28,31	paclitaxel	p21	MESH:D017239	644914	Chemical	Gene	confers|advcl|START_ENTITY confers|nsubj|expression expression|nmod|END_ENTITY	Low inducible expression of p21 -LRB- Cip1 -RRB- confers resistance to paclitaxel in BRAF mutant melanoma cells with acquired resistance to BRAF inhibitor .
21813412	0	paclitaxel	44,54	p27	12,15	paclitaxel	p27	MESH:D017239	10671	Chemical	Gene	cytotoxicity|amod|START_ENTITY role|nmod|cytotoxicity role|nmod|END_ENTITY	The role of p27 -LRB- Kip1 -RRB- in dasatinib-enhanced paclitaxel cytotoxicity in human ovarian_cancer cells .
10210535	0	paclitaxel	75,85	p53	8,11	paclitaxel	p53	MESH:D017239	7157	Chemical	Gene	determining|nmod|START_ENTITY alterations|advcl|determining alterations|nsubj|Role Role|nmod|gene gene|compound|END_ENTITY	Role of p53 and p16 gene alterations in determining response to concurrent paclitaxel and radiation in solid tumor .
10347252	0	paclitaxel	75,85	p53	122,125	paclitaxel	p53	MESH:D017239	7157	Chemical	Gene	induced|nmod|START_ENTITY induced|xcomp|lacking lacking|dobj|protein protein|amod|END_ENTITY	Overexpression of p21 -LRB- waf1 -RRB- decreases G2-M arrest and apoptosis induced by paclitaxel in human sarcoma cells lacking both p53 and functional Rb protein .
10736495	0	paclitaxel	20,30	p53	157,160	paclitaxel	p53	MESH:D017239	7157	Chemical	Gene	study|nmod|START_ENTITY study|dep|regimen regimen|nmod|activity activity|nmod|mutation mutation|compound|END_ENTITY	Phase I/II study of paclitaxel , carboplatin , and methotrexate in advanced transitional_cell_carcinoma : a well-tolerated regimen with activity independent of p53 mutation .
10810342	0	paclitaxel	51,61	p53	90,93	paclitaxel	p53	MESH:D017239	7157	Chemical	Gene	sensitivity|amod|START_ENTITY Induction|nmod|sensitivity Induction|nmod|transfection transfection|compound|END_ENTITY	Induction of senescence-like phenotype and loss of paclitaxel sensitivity after wild-type p53 gene transfection of p53-null human non-small_cell_lung_cancer H358 cells .
10951339	0	paclitaxel	41,51	p53	0,3	paclitaxel	p53	MESH:D017239	7157	Chemical	Gene	predict|advcl|START_ENTITY predict|nsubj|mutations mutations|compound|END_ENTITY	p53 mutations do not predict response to paclitaxel in metastatic nonsmall_cell_lung_carcinoma .
11052631	0	paclitaxel	70,80	p53	28,31	paclitaxel	p53	MESH:D017239	7157	Chemical	Gene	influence|xcomp|START_ENTITY influence|nsubj|factors factors|nmod|END_ENTITY	Multiple factors other than p53 influence colon_cancer sensitivity to paclitaxel .
11064345	0	paclitaxel	74,84	p53	123,126	paclitaxel	p53	MESH:D017239	7157	Chemical	Gene	effect|nmod|START_ENTITY enhances|dobj|effect enhances|nmod|END_ENTITY	Low dose fractionated radiation enhances the radiosensitization effect of paclitaxel in colorectal_tumor cells with mutant p53 .
11404489	0	paclitaxel	122,132	p53	44,47	paclitaxel	p53	MESH:D017239	7157	Chemical	Gene	chemotherapy|compound|START_ENTITY expression|nmod|chemotherapy expression|nsubj|Angiogenesis Angiogenesis|dep|END_ENTITY	Angiogenesis and apoptosis-related protein -LRB- p53 , bcl-2 , and bax -RRB- expression versus response of gastric_adenocarcinomas to paclitaxel and carboplatin chemotherapy .
11439344	0	paclitaxel	22,32	p53	60,63	paclitaxel	p53	MESH:D017239	7157	Chemical	Gene	cell|amod|START_ENTITY cell|dep|arrest arrest|amod|type-dependent type-dependent|dep|END_ENTITY	Low concentrations of paclitaxel induce cell type-dependent p53 , p21 and G1/G2 arrest instead of mitotic_arrest : molecular determinants of paclitaxel-induced cytotoxicity .
11458051	0	paclitaxel	54,64	p53	11,14	paclitaxel	p53	MESH:D017239	7157	Chemical	Gene	susceptibility|amod|START_ENTITY determinant|nmod|susceptibility mutation|nmod|determinant mutation|compound|END_ENTITY	Functional p53 mutation as a molecular determinant of paclitaxel and gemcitabine susceptibility in human bladder_cancer .
11774260	0	paclitaxel	30,40	p53	60,63	paclitaxel	p53	MESH:D017239	7157	Chemical	Gene	induced|nmod|START_ENTITY Apoptosis|acl|induced associated|nsubjpass|Apoptosis associated|nmod|upregulation upregulation|compound|END_ENTITY	Apoptosis induced by low-dose paclitaxel is associated with p53 upregulation in nasopharyngeal_carcinoma cells .
12168940	0	paclitaxel	123,133	p53	37,40	paclitaxel	p53	MESH:D017239	7157	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|Correlation Correlation|nmod|outcome outcome|nmod|END_ENTITY	Correlation of clinical outcome with p53 and p21 status in patients with advanced transitional-cell_carcinoma treated with paclitaxel and carboplatin .
12530065	0	paclitaxel	83,93	p53	22,25	paclitaxel	p53	MESH:D017239	7157	Chemical	Gene	sensitizes|nmod|START_ENTITY sensitizes|nsubj|expression expression|nmod|END_ENTITY	Reduced expression of p53 and p21WAF1/CIP1 sensitizes human breast_cancer cells to paclitaxel and its combination with 5-fluorouracil .
12598349	0	paclitaxel	73,83	p53	15,18	paclitaxel	p53	MESH:D017239	7157	Chemical	Gene	using|dobj|START_ENTITY chemotherapy|xcomp|using chemotherapy|nsubj|Correlation Correlation|nmod|status status|compound|END_ENTITY	Correlation of p53 status with outcome of neoadjuvant chemotherapy using paclitaxel and doxorubicin in stage IIIB breast_cancer .
12715164	0	paclitaxel	38,48	p53	0,3	paclitaxel	p53	MESH:D017239	7157	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	p53 expression and resistance against paclitaxel in patients with metastatic breast_cancer .
12715164	10	paclitaxel	1265,1275	p53	1229,1232	paclitaxel	p53	MESH:D017239	7157	Chemical	Gene	responded|xcomp|START_ENTITY responded|nsubj|None None|nmod|tumors tumors|nmod|expression expression|compound|END_ENTITY	None of the tumors with p53 expression -LRB- n = 11 -RRB- responded to paclitaxel .
12897130	0	paclitaxel	80,90	p53	23,26	paclitaxel	p53	MESH:D017239	7157	Chemical	Gene	catastrophe|nmod|START_ENTITY leads|nmod|catastrophe leads|dep|Silencing Silencing|nmod|END_ENTITY	Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel -LRB- taxol -RRB- - exposed cells .
16459017	0	paclitaxel	137,147	p53	27,30	paclitaxel	p53	MESH:D017239	7157	Chemical	Gene	chemotherapy|nmod|START_ENTITY treated|nmod|chemotherapy ovarian_carcinoma|acl|treated resected|dobj|ovarian_carcinoma resected|nsubj|significance significance|nmod|mutation mutation|compound|END_ENTITY	Prognostic significance of p53 mutation in suboptimally resected advanced ovarian_carcinoma treated with the combination chemotherapy of paclitaxel and carboplatin .
17960385	0	paclitaxel	77,87	p53	14,17	paclitaxel	p53	MESH:D017239	7157	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|compound|END_ENTITY	The effect of p53 gene expression on the inhibition of cell proliferation by paclitaxel .
20878066	5	paclitaxel	654,664	p53	584,587	paclitaxel	p53	MESH:D017239	7157	Chemical	Gene	effect|nmod:poss|START_ENTITY enhancement|nmod|effect status-dependent|nsubj|enhancement found|ccomp|status-dependent found|nmod|report report|acl|using using|nmod|expression expression|compound|END_ENTITY	In this report , using a cell line with knock-down p53 expression through siRNA , we found that amifostine enhancement of paclitaxel 's anticancer effect is p53 status-dependent .
20944137	0	paclitaxel	64,74	p53	11,14	paclitaxel	p53	MESH:D017239	7157	Chemical	Gene	sensitizes|nmod|START_ENTITY sensitizes|nsubj|protein protein|compound|END_ENTITY	Increasing p53 protein sensitizes non-small_cell_lung_cancer to paclitaxel and cisplatin in vitro .
24565839	0	paclitaxel	49,59	p53	0,3	paclitaxel	p53	MESH:D017239	7157	Chemical	Gene	death|amod|START_ENTITY SETDB1|nmod|death SETDB1|nsubj|down-regulates down-regulates|compound|END_ENTITY	p53 down-regulates SETDB1 gene expression during paclitaxel induced-cell death .
8553077	0	paclitaxel	13,23	p53	105,108	paclitaxel	p53	MESH:D017239	7157	Chemical	Gene	START_ENTITY|dep|links links|nmod|status status|compound|END_ENTITY	Single-agent paclitaxel by 3-hour infusion in the treatment of non-small_cell_lung_cancer : links between p53 and K-ras gene status and chemosensitivity .
9041188	0	paclitaxel	77,87	p53	0,3	paclitaxel	p53	MESH:D017239	7157	Chemical	Gene	affect|advcl|START_ENTITY affect|nsubj|status status|compound|END_ENTITY	p53 status does not affect sensitivity of human ovarian_cancer cell lines to paclitaxel .
9569030	0	paclitaxel	50,60	p53	98,101	paclitaxel	p53	MESH:D017239	22060(Tax:10090)	Chemical	Gene	sensitivity|nmod|START_ENTITY role|nmod|sensitivity role|nmod|vinca_alkaloids vinca_alkaloids|nmod|cells cells|nummod|END_ENTITY	The role of MAP4 expression in the sensitivity to paclitaxel and resistance to vinca_alkaloids in p53 mutant cells .
9633517	0	paclitaxel	85,95	p53	16,19	paclitaxel	p53	MESH:D017239	7157	Chemical	Gene	sensitivity|acl|START_ENTITY increases|dobj|sensitivity increases|nsubj|Inactivation Inactivation|nmod|END_ENTITY	Inactivation of p53 in a human ovarian_cancer cell line increases the sensitivity to paclitaxel by inducing G2/M arrest and apoptosis .
9633517	2	paclitaxel	540,550	p53	432,435	paclitaxel	p53	MESH:D017239	7157	Chemical	Gene	treatment|amod|START_ENTITY induce|nmod|treatment clone|acl|induce inability|nmod|clone measuring|dobj|inability verified|advcl|measuring verified|nsubjpass|inactivation inactivation|nmod|END_ENTITY	The inactivation of wt p53 in A2780/E6 was verified by measuring the inability of the clone to induce p53 and p21 expression after paclitaxel treatment .
17211474	0	paclitaxel	38,48	progesterone_receptor	12,33	paclitaxel	progesterone receptor	MESH:D017239	5241	Chemical	Gene	resistance|amod|START_ENTITY END_ENTITY|nmod|resistance	Role of the progesterone_receptor for paclitaxel resistance in primary breast_cancer .
15245881	0	paclitaxel	61,71	substance_P	8,19	paclitaxel	substance P	MESH:D017239	6863	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Role Role|nmod|END_ENTITY	Role of substance_P in hypersensitivity_reactions induced by paclitaxel , an anticancer agent .
17640356	0	paclitaxel	110,120	thymidine_phosphorylase	14,37	paclitaxel	thymidine phosphorylase	MESH:D017239	1890	Chemical	Gene	increased|nmod|START_ENTITY increased|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of thymidine_phosphorylase in peripheral blood cells of breast_cancer patients is not increased by paclitaxel .
22164494	0	paeoniflorin	12,24	CTGF	43,47	paeoniflorin	CTGF	MESH:C015423	14219(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expressions expressions|nmod|END_ENTITY	-LSB- Effects of paeoniflorin on expressions of CTGF , PDGF and TNF-alpha in mice with hepatic_fibrosis due to Schistosoma_japonicum infection -RSB- .
24812806	0	paeoniflorin	11,23	TGF-beta1	40,49	paeoniflorin	TGF-beta1	MESH:C015423	21803(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|nmod|END_ENTITY	-LSB- Effect of paeoniflorin on secretion of TGF-beta1 from macrophages in mice -RSB- .
16927833	0	paeonol	23,30	tyrosinase	59,69	paeonol	tyrosinase	MESH:C013638	7299	Chemical	Gene	kinetics|nmod|START_ENTITY END_ENTITY|nsubj|kinetics	Inhibitory kinetics of paeonol on the activity of mushroom tyrosinase oxidizing L-dopa .
24120880	0	paeonol_thiosemicarbazone	57,82	tyrosinase	105,115	paeonol thiosemicarbazone	tyrosinase	null	7299	Chemical	Gene	evaluation|nmod|START_ENTITY analogues|nsubj|evaluation analogues|nmod|inhibitors inhibitors|compound|END_ENTITY	Synthesis , characterization and biological evaluation of paeonol_thiosemicarbazone analogues as mushroom tyrosinase inhibitors .
22585935	0	palate	62,68	Hsp90	26,31	palate	Hsp90	null	15519(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Gene expression of Hsp70 , Hsp90 and Hsp110 families in normal palate and cleft_palate during mouse embryogenesis .
12887311	0	palate	7,13	PLUNC	0,5	palate	PLUNC	null	51297	Chemical	Gene	proteins|dep|START_ENTITY proteins|compound|END_ENTITY	PLUNC -LRB- palate , lung and nasal epithelial clone -RRB- proteins in human nasal lavage fluid .
21512288	0	palatinose	48,58	GLP-1	0,5	palatinose	GLP-1	MESH:C008189	24952(Tax:10116)	Chemical	Gene	response|nmod|START_ENTITY secretion|nmod|response secretion|compound|END_ENTITY	GLP-1 secretion in response to oral and luminal palatinose -LRB- isomaltulose -RRB- in rats .
15878107	0	palifermin	39,49	keratinocyte_growth_factor	11,37	palifermin	keratinocyte growth factor	MESH:D051523	14178(Tax:10090)	Chemical	Gene	Effects|dep|START_ENTITY Effects|nmod|END_ENTITY	Effects of keratinocyte_growth_factor -LRB- palifermin -RRB- administration protocols on oral_mucositis -LRB- mouse -RRB- induced by fractionated irradiation .
21916922	0	palifermin	28,38	keratinocyte_growth_factor	58,84	palifermin	keratinocyte growth factor	MESH:D051523	2252	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Immunomodulatory effects of palifermin -LRB- recombinant human keratinocyte_growth_factor -RRB- in an SLE-like model of chronic_graft-versus-host_disease .
25187801	0	palifermin	40,50	keratinocyte_growth_factor	12,38	palifermin	keratinocyte growth factor	MESH:D051523	29348(Tax:10116)	Chemical	Gene	Efficacy|appos|START_ENTITY Efficacy|nmod|END_ENTITY	Efficacy of keratinocyte_growth_factor -LRB- palifermin -RRB- for the treatment of caustic esophageal burns .
22025345	0	palladacycles	19,32	C-Br	34,38	palladacycles	C-Br	null	873	Chemical	Gene	START_ENTITY|dep|activation activation|amod|END_ENTITY	New seven membered palladacycles : C-Br bond activation of 2-bromo-pyridine derivative by Pd -LRB- II -RRB- .
26267684	0	pallium	35,42	CD40	12,16	pallium	CD40	null	171369(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	-LSB- Changes in CD40 expression in the pallium and hippocampus in epileptic rats -RSB- .
16304351	0	palmitate	89,98	AMP-activated_protein_kinase	14,42	palmitate	AMP-activated protein kinase	CHEBI:7896	78975(Tax:10116)	Chemical	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nsubj|Regulation Regulation|nmod|carboxylase carboxylase|amod|END_ENTITY	Regulation of AMP-activated_protein_kinase and acetyl-CoA carboxylase phosphorylation by palmitate in skeletal muscle cells .
23095119	4	palmitate	775,784	AMPK	746,750	palmitate	AMPK	CHEBI:7896	78975(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Glucose decreased AMPK activity and effects of palmitate and glucose on AMPK activity were antagonistic .
8962097	0	palmitate	37,46	Gs_alpha	25,33	palmitate	Gs alpha	CHEBI:7896	2778	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Reciprocal regulation of Gs_alpha by palmitate and the beta gamma subunit .
12688632	0	palmitate	29,38	Insulin	0,7	palmitate	Insulin	CHEBI:7896	3630	Chemical	Gene	induced|nmod|START_ENTITY secretion|acl|induced secretion|compound|END_ENTITY	Insulin secretion induced by palmitate -- a process fully dependent on glucose concentration .
26701913	0	palmitate	70,79	N-Ras	64,69	palmitate	N-Ras	CHEBI:7896	4893	Chemical	Gene	turnover|compound|START_ENTITY turnover|compound|END_ENTITY	ABHD17 proteins are novel protein depalmitoylases that regulate N-Ras palmitate turnover and subcellular localization .
18559892	12	palmitate	1425,1434	PERK	1406,1410	palmitate	CHOP	CHEBI:7896	1649	Chemical	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	PERK activation by palmitate also contributes to beta-cell apoptosis via CHOP .
25724269	0	palmitate	39,48	PP2A	20,24	palmitate	PP2A	CHEBI:7896	5524	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Independent role of PP2A and mTORc1 in palmitate induced podocyte death .
25724269	0	palmitate	39,48	PP2A	20,24	palmitate	PP2A	CHEBI:7896	5524	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Independent role of PP2A and mTORc1 in palmitate induced podocyte death .
25163918	0	palmitate	15,24	TBC1D1	0,6	palmitate	TBC1D1	CHEBI:7896	57915(Tax:10090)	Chemical	Gene	oxidation|amod|START_ENTITY reduces|dobj|oxidation reduces|nsubj|END_ENTITY	TBC1D1 reduces palmitate oxidation by inhibiting b-HAD activity in skeletal muscle .
25600807	0	palmitate	31,40	TRAM1	0,5	palmitate	TRAM1	CHEBI:7896	23471	Chemical	Gene	protect|nmod|START_ENTITY protect|nsubj|END_ENTITY	TRAM1 protect HepG2 cells from palmitate induced insulin resistance through ER stress-JNK pathway .
23465595	0	palmitate	93,102	Toll-like_receptor_4	0,20	palmitate	Toll-like receptor 4	CHEBI:7896	7099	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|signaling signaling|compound|END_ENTITY	Toll-like_receptor_4 signaling is required for induction of gluconeogenic gene expression by palmitate in human hepatic_carcinoma cells .
8243440	0	palmitate	14,23	albumin	41,48	palmitate	albumin	CHEBI:7896	213	Chemical	Gene	START_ENTITY|xcomp|binding binding|xcomp|serum serum|dobj|END_ENTITY	Valproate and palmitate binding to serum albumin in valproate-treated patients .
18815554	0	palmitate	89,98	insulin	118,125	palmitate	insulin	CHEBI:7896	3630	Chemical	Gene	effect|nmod|START_ENTITY pathway|nmod|effect pathway|nmod|secretion secretion|compound|END_ENTITY	Involvement of phosphatidylinositol-3 kinase/AKT/PKCzeta / lambda pathway in the effect of palmitate on glucose-induced insulin secretion .
19607692	0	palmitate	39,48	insulin	102,109	palmitate	insulin	CHEBI:7896	3630	Chemical	Gene	levels|nmod|START_ENTITY levels|acl|implicated implicated|nmod|secretion secretion|compound|END_ENTITY	Proteins altered by elevated levels of palmitate or glucose implicated in impaired glucose-stimulated insulin secretion .
22132232	0	palmitate	93,102	insulin	45,52	palmitate	insulin	CHEBI:7896	3630	Chemical	Gene	signaling|nmod|START_ENTITY signaling|compound|END_ENTITY	Synergy analysis reveals association between insulin signaling and desmoplakin expression in palmitate treated HepG2 cells .
24035997	0	palmitate	59,68	insulin	72,79	palmitate	insulin	CHEBI:7896	3630	Chemical	Gene	acute|nmod|START_ENTITY involved|nmod|acute involved|nmod|secretion secretion|compound|END_ENTITY	FFAR1 is involved in both the acute and chronic effects of palmitate on insulin secretion .
24069458	0	palmitate	138,147	insulin	35,42	palmitate	insulin	CHEBI:7896	3630	Chemical	Gene	synthesis|nmod|START_ENTITY affecting|dobj|synthesis results|advcl|affecting results|nsubj|weight_gain weight_gain|nmod|treatment treatment|compound|END_ENTITY	Adipose weight_gain during chronic insulin treatment of mice results from changes in lipid storage without affecting de novo synthesis of palmitate .
24557677	0	palmitate	34,43	insulin	133,140	palmitate	insulin	CHEBI:7896	3630	Chemical	Gene	kinase|nmod|START_ENTITY kinase|nmod|resistance resistance|compound|END_ENTITY	Inhibition of protein kinase B by palmitate in the insulin signaling of HepG2 cells and the preventive effect of arachidonic_acid on insulin resistance .
24557677	0	palmitate	34,43	insulin	51,58	palmitate	insulin	CHEBI:7896	3630	Chemical	Gene	START_ENTITY|nmod|signaling signaling|compound|END_ENTITY	Inhibition of protein kinase B by palmitate in the insulin signaling of HepG2 cells and the preventive effect of arachidonic_acid on insulin resistance .
26301632	0	palmitate	21,30	insulin	39,46	palmitate	insulin	CHEBI:7896	3630	Chemical	Gene	resistance|amod|START_ENTITY resistance|compound|END_ENTITY	PRDX1 is involved in palmitate induced insulin resistance via regulating the activity of p38MAPK in HepG2 cells .
18471413	0	palmitate	111,120	interleukin-6	52,65	palmitate	interleukin-6	CHEBI:7896	16193(Tax:10090)	Chemical	Gene	-RSB-|amod|START_ENTITY cultured|nmod|-RSB- cells|acl|cultured cells|amod|END_ENTITY	-LSB- Pollen Typhae total flavones inhibit expression of interleukin-6 in C2C12 skeletal muscle cells cultured with palmitate -RSB- .
20063116	0	palmitate	44,53	pro-insulin	68,79	palmitate	pro-insulin	CHEBI:7896	3630	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|expression expression|amod|END_ENTITY	Blockage of ceramide metabolism exacerbates palmitate inhibition of pro-insulin gene expression in pancreatic beta-cells .
25761653	0	palmitic_acid	104,117	HIF1A-AS1	161,170	palmitic acid	HIF1A-AS1	MESH:D019308	100750246	Chemical	Gene	START_ENTITY|nmod|suppression suppression|nmod|END_ENTITY	Clopidogrel reduces apoptosis and promotes proliferation of human vascular endothelial cells induced by palmitic_acid via suppression of the long non-coding RNA HIF1A-AS1 in vitro .
25761653	0	palmitic_acid	104,117	HIF1A-AS1	161,170	palmitic acid	HIF1A-AS1	MESH:D019308	100750246	Chemical	Gene	START_ENTITY|nmod|suppression suppression|nmod|END_ENTITY	Clopidogrel reduces apoptosis and promotes proliferation of human vascular endothelial cells induced by palmitic_acid via suppression of the long non-coding RNA HIF1A-AS1 in vitro .
3805022	0	palmitic_acid	61,74	Ligatin	0,7	palmitic acid	Ligatin	MESH:D019308	100529141	Chemical	Gene	protein|nmod|START_ENTITY END_ENTITY|dep|protein	Ligatin : a peripheral membrane protein with covalently bound palmitic_acid .
209828	0	palmitic_acid	25,38	albumin	55,62	palmitic acid	albumin	MESH:D019308	213	Chemical	Gene	START_ENTITY|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Binding of spin-labeled palmitic_acid by bovine serum albumin -RSB- .
22408252	0	palmitic_acid	26,39	mTOR	103,107	palmitic acid	mTOR	MESH:D019308	21977(Tax:10090)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of autophagy by palmitic_acid via protein_kinase_C-mediated signaling pathway independent of mTOR -LRB- mammalian_target_of_rapamycin -RRB- .
20548961	0	palmitoyl	105,114	Zdhhc13	78,85	palmitoyl	Zdhhc13	CHEBI:45021	243983(Tax:10090)	Chemical	Gene	acyltransferase|amod|START_ENTITY coding|nmod|acyltransferase Mice|dep|coding Mice|amod|due due|nmod|mutation mutation|nmod|END_ENTITY	Mice with alopecia , osteoporosis , and systemic_amyloidosis due to mutation in Zdhhc13 , a gene coding for palmitoyl acyltransferase .
1343843	0	palmitoyl_esters	43,59	protein_kinase_C	14,30	palmitoyl esters	protein kinase C	null	112476	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|activity activity|amod|END_ENTITY	Modulation of protein_kinase_C activity by palmitoyl_esters of maltose .
19625629	0	palosuran	78,87	urotensin-II_receptor	45,66	palosuran	urotensin-II receptor	MESH:C493249	2837	Chemical	Gene	START_ENTITY|nsubj|Pharmacokinetics Pharmacokinetics|nmod|antagonist antagonist|amod|END_ENTITY	Pharmacokinetics and pharmacodynamics of the urotensin-II_receptor antagonist palosuran in healthy male subjects .
19843053	0	palosuran	47,56	urotensin-II_receptor	14,35	palosuran	urotensin-II receptor	MESH:C493249	2837	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|antagonist antagonist|amod|END_ENTITY	Effect of the urotensin-II_receptor antagonist palosuran on secretion of and sensitivity to insulin in patients with Type_2_diabetes_mellitus .
18318439	0	palosuran	73,82	urotensin_II	23,35	palosuran	urotensin II	MESH:C493249	29180(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|END_ENTITY	Hemodynamic effects of urotensin_II and its specific receptor antagonist palosuran in cirrhotic rats .
2570066	1	palytoxin	118,127	epidermal_growth_factor_receptor	82,114	palytoxin	epidermal growth factor receptor	MESH:C010272	13649(Tax:10090)	Chemical	Gene	Down-modulation|nmod|START_ENTITY Down-modulation|nmod|END_ENTITY	Down-modulation of the epidermal_growth_factor_receptor by palytoxin .
2887282	0	palytoxin	67,76	epidermal_growth_factor_receptor	31,63	palytoxin	epidermal growth factor receptor	MESH:C010272	1956	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Heterologous regulation of the epidermal_growth_factor_receptor by palytoxin , a non-12-O-tetradecanoylphorbol-13-acetate-type tumor promoter .
1185535	0	pamaquine	77,86	albumin	103,110	pamaquine	albumin	MESH:C004331	213	Chemical	Gene	binding|nmod|START_ENTITY binding|nmod|END_ENTITY	Fluorometric determination of drug-protein association constants : binding of pamaquine by bovine serum albumin .
12507583	0	pamidronate	10,21	TNF-alpha	55,64	pamidronate	TNF-alpha	MESH:C019248	21926(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|stimulation stimulation|nmod|release release|amod|END_ENTITY	Effect of pamidronate on the stimulation of macrophage TNF-alpha release by ultra-high-molecular-weight polyethylene particles : a role for apoptosis .
12507583	9	pamidronate	1460,1471	TNF-alpha	1496,1505	pamidronate	TNF-alpha	MESH:C019248	21926(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|amod|END_ENTITY	Our results also showed that at 10 particles/macrophage , pamidronate inhibits UHMWPE-induced TNF-alpha release by 12 % , 14 % , and 23 % respectively after 24 , 48 , and 72 h -LRB- p < 0.05 vs. 24 and 48 h -RRB- .
8352010	0	panaxatriol_ginsenoside	21,44	interleukin-1	73,86	panaxatriol ginsenoside	interleukin-1	null	3552	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Promoting effect of panaxatriol_ginsenoside on gene expression of human interleukin-1 -RSB- .
10704940	0	panaxydol	62,71	p27	40,43	panaxydol	p27	MESH:C055778	3429	Chemical	Gene	increase|nmod|START_ENTITY increase|amod|END_ENTITY	Induction of G -LRB- 1 -RRB- cell cycle arrest and p27 -LRB- KIP1 -RRB- increase by panaxydol isolated from Panax_ginseng .
18199429	0	panaxynol	28,37	ERK1/2	66,72	panaxynol	ERK1/2	MESH:C018541	50689;116590	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|inhibition inhibition|nmod|END_ENTITY	Antiproliferative effect of panaxynol on RASMCs via inhibition of ERK1/2 and CREB .
10660108	0	pancreastatin	26,39	chromogranin_A	10,24	pancreastatin	chromogranin A	MESH:C050836	1113	Chemical	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of chromogranin_A -LRB- pancreastatin -RRB- fragment on invasion of prostate_cancer cells .
2695319	0	pancreastatin	11,24	insulin	28,35	pancreastatin	insulin	MESH:C050836	483665(Tax:9615)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of pancreastatin on insulin and pancreatic_polypeptide secretion in the dog .
2695319	3	pancreastatin_did	416,433	insulin	465,472	pancreastatin did	insulin	null	483665(Tax:9615)	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|END_ENTITY	However , i.v. pancreastatin_did inhibit the i.v. CCK-8-induced insulin but not PP release .
24297862	0	panobinostat	107,119	HDAC	91,95	panobinostat	HDAC	MESH:C496932	9734	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Reducing TNF receptor 2 + regulatory T cells via the combined action of azacitidine and the HDAC inhibitor , panobinostat for clinical benefit in acute_myeloid_leukemia patients .
24429877	0	panobinostat	57,69	HDAC	74,78	panobinostat	HDAC	MESH:C496932	9734	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	A phase I , pharmacokinetic , and pharmacodynamic study of panobinostat , an HDAC inhibitor , combined with erlotinib in patients with advanced aerodigestive tract tumors .
22344699	0	pantoprazole	31,43	ABCG2	49,54	pantoprazole	ABCG2	MESH:C064276	312382(Tax:10116)	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Stereoselective interaction of pantoprazole with ABCG2 .
22355035	0	pantoprazole	31,43	ABCG2	49,54	pantoprazole	ABCG2	MESH:C064276	312382(Tax:10116)	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Stereoselective interaction of pantoprazole with ABCG2 .
25704601	0	pantoprazole	10,22	insulin	26,33	pantoprazole	insulin	MESH:C064276	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of pantoprazole on insulin secretion in drug-na ve patients with type 2 diabetes .
609151	2	papaverine	149,159	DT_diaphorase	176,189	papaverine	DT diaphorase	MESH:D010208	100135582(Tax:10141)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The differential effect of papaverine and rotenone on DT_diaphorase .
19066855	0	papaverine	75,85	PDE10A	57,63	papaverine	PDE10A	MESH:D010208	63885(Tax:10116)	Chemical	Gene	START_ENTITY|dep|Evaluating Evaluating|dobj|profile profile|nmod|inhibitor inhibitor|compound|END_ENTITY	Evaluating the antipsychotic profile of the preferential PDE10A inhibitor , papaverine .
20447563	0	papaverine	18,28	PDE10A	57,63	papaverine	PDE10A	MESH:D010208	63885(Tax:10116)	Chemical	Gene	labeled|dobj|START_ENTITY labeled|nmod|END_ENTITY	Carbon-11 labeled papaverine as a PET tracer for imaging PDE10A : radiosynthesis , in vitro and in vivo evaluation .
21816164	0	papaverine	22,32	PDE10A	4,10	papaverine	PDE10A	MESH:D010208	63885(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	The PDE10A inhibitor , papaverine , differentially activates ERK in male and female rat striatal slices .
419151	0	papaverine	14,24	renin	37,42	papaverine	renin	MESH:D010208	5972	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|compound|END_ENTITY	The effect of papaverine on in vitro renin secretion .
10231387	0	para-alkylphenols	27,44	estrogen_receptor	56,73	para-alkylphenols	estrogen receptor	null	2099	Chemical	Gene	requirements|nmod|START_ENTITY requirements|nmod|END_ENTITY	Structural requirements of para-alkylphenols to bind to estrogen_receptor .
10760098	0	para-aminohippurate	14,33	MRP2	83,87	para-aminohippurate	MRP2	CHEBI:64703	1244	Chemical	Gene	transport|amod|START_ENTITY transport|nmod|END_ENTITY	ATP-dependent para-aminohippurate transport by apical multidrug resistance protein MRP2 .
18249574	0	para-nitrophenyl	13,29	PHO13	53,58	para-nitrophenyl	PHO13	MESH:C024719	851362(Tax:4932)	Chemical	Gene	phosphatase|amod|START_ENTITY phosphatase|appos|END_ENTITY	Deleting the para-nitrophenyl phosphatase -LRB- pNPPase -RRB- , PHO13 , in recombinant Saccharomyces_cerevisiae improves growth and ethanol production on D-xylose .
18221308	0	para-substituted_aromatic_sulphonamides	26,65	CAII	69,73	para-substituted aromatic sulphonamides	CAII	null	760	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Comparative QSAR study on para-substituted_aromatic_sulphonamides as CAII inhibitors : information versus topological -LRB- distance-based and connectivity -RRB- indices .
25644523	0	parabens	93,101	bisphenol_A	32,43	parabens	bisphenol A	MESH:D010226	667	Chemical	Gene	Determination|nmod|START_ENTITY Determination|nmod|END_ENTITY	Determination and separation of bisphenol_A , phthalate metabolites and structural isomers of parabens in human urine with conventional high-pressure liquid chromatography combined with electrospray ionisation tandem mass spectrometry .
14504673	0	paracetamol	104,115	5-HT1B	36,42	paracetamol	5-HT1B	MESH:D000082	25075(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY involvement|nmod|effect involvement|nmod|END_ENTITY	Differential involvement of central 5-HT1B and 5-HT3_receptor subtypes in the antinociceptive effect of paracetamol .
9696492	0	paracetamol	73,84	Tumor_necrosis_factor	0,21	paracetamol	Tumor necrosis factor	MESH:D000082	7124	Chemical	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Tumor_necrosis_factor genomic polymorphism and outcome of acetaminophen -LRB- paracetamol -RRB- - induced acute_liver_failure .
16911100	0	paracetamol	10,21	cyclooxygenase-2	39,55	paracetamol	cyclooxygenase-2	MESH:D000082	5743	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|amod|END_ENTITY	Combining paracetamol with a selective cyclooxygenase-2 inhibitor for acute_pain relief after third molar surgery : a randomized , double-blind , placebo-controlled study .
17884974	0	paracetamol	15,26	cyclooxygenase-2	43,59	paracetamol	cyclooxygenase-2	MESH:D000082	5743	Chemical	Gene	Acetaminophen|appos|START_ENTITY inhibitor|nsubj|Acetaminophen inhibitor|amod|END_ENTITY	Acetaminophen -LRB- paracetamol -RRB- is a selective cyclooxygenase-2 inhibitor in man .
20584199	0	paracetamol	66,77	cyclooxygenase-2	37,53	paracetamol	cyclooxygenase-2	MESH:D000082	19225(Tax:10090)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Inhibition of the diclofenac-induced cyclooxygenase-2 activity by paracetamol in cultured macrophages is not related to the intracellular lipid hydroperoxide tone .
20654292	0	paracetamol	16,27	cytochrome_P-450	69,85	paracetamol	cytochrome P-450	MESH:D000082	25251(Tax:10116)	Chemical	Gene	Cytotoxicity|nmod|START_ENTITY Cytotoxicity|dep|Role Role|nmod|END_ENTITY	Cytotoxicity of paracetamol and 3,5-dihalogenated analogues : Role of cytochrome_P-450 and formation of GSH conjugates and protein adducts .
6867468	0	paracetamol	24,35	cytochrome_P-450	64,80	paracetamol	cytochrome P-450	MESH:D000082	25251(Tax:10116)	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Metabolic activation of paracetamol by highly purified forms of cytochrome_P-450 .
2582614	0	paracetamol	110,121	glutathione_S-transferase	7,32	paracetamol	glutathione S-transferase	MESH:D000082	373156	Chemical	Gene	markers|nmod|START_ENTITY aminotransferase|nmod|markers sensitive|nmod|aminotransferase sensitive|nsubj|END_ENTITY	Plasma glutathione_S-transferase and F protein are more sensitive than alanine aminotransferase as markers of paracetamol -LRB- acetaminophen -RRB- - induced liver_damage .
3965363	0	paracetamol	52,63	glutathione_S-transferase	7,32	paracetamol	glutathione S-transferase	MESH:D000082	373156	Chemical	Gene	overdose|compound|START_ENTITY measurements|nmod|overdose measurements|amod|END_ENTITY	Plasma glutathione_S-transferase measurements after paracetamol overdose : evidence for early hepatocellular_damage .
8010073	0	paracetamol	12,23	glutathione_S-transferase	27,52	paracetamol	glutathione S-transferase	MESH:D000082	54486(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	-LSB- Effects of paracetamol on glutathione_S-transferase activity in mice -RSB- .
2853663	0	parachlorophenylalanine	11,34	growth_hormone	68,82	parachlorophenylalanine	growth hormone	null	2688	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of parachlorophenylalanine , quipazine and cyproheptadine on growth_hormone and adrenocorticotropin secretion in steers .
8276424	0	paranitrophenyl-beta-D-galactopyranoside	56,96	beta-galactosidase	13,31	paranitrophenyl-beta-D-galactopyranoside	beta-galactosidase	null	2720	Chemical	Gene	hydrolysis|nmod|START_ENTITY hydrolysis|amod|END_ENTITY	Evidence for beta-galactosidase catalyzed hydrolysis of paranitrophenyl-beta-D-galactopyranoside anchored in cyclodextrins .
20032868	0	paraoxon	104,112	acetylcholinesterase	44,64	paraoxon	acetylcholinesterase	MESH:D010261	43	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubj|reactivation reactivation|nmod|END_ENTITY	Novel bisquaternary oximes -- reactivation of acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon .
3257593	0	paraoxon	11,19	interleukin_2	93,106	paraoxon	interleukin 2	MESH:D010261	116562(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|system system|amod|END_ENTITY	Effects of paraoxon , p-nitrophenol , phenyl_saligenin_cyclic_phosphate , and phenol on the rat interleukin_2 system .
2557706	0	paraquat	10,18	AICE	70,74	paraquat	AICE	MESH:D010269	610668(Tax:9615)	Chemical	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Effect of paraquat on serum and lung angiotensin_I_converting_enzyme -LRB- AICE -RRB- activity in beagle_dogs .
25815693	0	paraquat	119,127	Connective_tissue_growth_factor	0,31	paraquat	Connective tissue growth factor	MESH:D010269	1490	Chemical	Gene	stimulates|nmod|START_ENTITY stimulates|nsubj|END_ENTITY	Connective_tissue_growth_factor stimulates the proliferation , migration and differentiation of lung fibroblasts during paraquat - induced pulmonary_fibrosis .
24048193	0	paraquat	71,79	HIF-1a	31,37	paraquat	HIF-1a	MESH:D010269	29560(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Expression Expression|nmod|END_ENTITY	Expression and significance of HIF-1a in pulmonary_fibrosis induced by paraquat .
26813466	0	paraquat	72,80	KLF2	0,4	paraquat	KLF2	MESH:D010269	10365	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|END_ENTITY	KLF2 and caveolin-1 as early indicators of acute_lung_injury induced by paraquat .
2557706	0	paraquat	10,18	angiotensin_I_converting_enzyme	37,68	paraquat	angiotensin I converting enzyme	MESH:D010269	610668(Tax:9615)	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Effect of paraquat on serum and lung angiotensin_I_converting_enzyme -LRB- AICE -RRB- activity in beagle_dogs .
6250433	0	paraquat	10,18	angiotensin_converting_enzyme	28,57	paraquat	angiotensin converting enzyme	MESH:D010269	11421(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of paraquat on serum angiotensin_converting_enzyme .
21787677	0	paraquat	153,161	glial_cell_line-derived_neurotrophic_factor	25,68	paraquat	glial cell line-derived neurotrophic factor	MESH:D010269	2668	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|effect effect|nmod|END_ENTITY	Protective effect of the glial_cell_line-derived_neurotrophic_factor -LRB- GDNF -RRB- on human mesencephalic neuron-derived cells against neurotoxicity induced by paraquat .
25891458	0	paraquat	50,58	heme_oxygenase-1	15,31	paraquat	heme oxygenase-1	MESH:D010269	15368(Tax:10090)	Chemical	Gene	tissue|nmod|START_ENTITY END_ENTITY|nmod|tissue	-LSB- Expression of heme_oxygenase-1 in lung tissue of paraquat poisoned mice and its significance -RSB- .
26049187	0	paraquat	50,58	heme_oxygenase-1	15,31	paraquat	heme oxygenase-1	MESH:D010269	15368(Tax:10090)	Chemical	Gene	tissue|nmod|START_ENTITY END_ENTITY|nmod|tissue	-LSB- Expression of heme_oxygenase-1 in lung tissue of paraquat poisoned mice and its significance -RSB- .
21619786	0	paraquat	63,71	miR-133b	40,48	paraquat	miR-133b	MESH:D010269	100314078(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	-LSB- Induction of cell damage and change of miR-133b expression by paraquat in PC12 cells -RSB- .
3707996	0	paraquat	48,56	superoxide_dismutase	82,102	paraquat	superoxide dismutase	MESH:D010269	100274012(Tax:4577)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|genes genes|amod|END_ENTITY	Effect of the free radical-generating herbicide paraquat on the expression of the superoxide_dismutase -LRB- Sod -RRB- genes in maize .
11401758	0	parathion	70,79	acetylcholinesterase	112,132	parathion	acetylcholinesterase	MESH:D010278	83817(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nmod|inhibition inhibition|amod|END_ENTITY	A rat mammary tumor model induced by the organophosphorous pesticides parathion and malathion , possibly through acetylcholinesterase inhibition .
2339415	0	parathion	77,86	acetylcholinesterase	29,49	parathion	acetylcholinesterase	MESH:D010278	83817(Tax:10116)	Chemical	Gene	exposures|compound|START_ENTITY course|nmod|exposures course|nmod|END_ENTITY	Time course of inhibition of acetylcholinesterase and aliesterases following parathion and paraoxon exposures in rats .
9336056	0	parathion	12,21	acetylcholinesterase	25,45	parathion	acetylcholinesterase	MESH:D010278	83817(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	-LSB- Effects of parathion on acetylcholinesterase activity in rat kidney -RSB- .
5264	0	parathion	29,38	cytochrome_P-450	98,114	parathion	cytochrome P-450	MESH:D010278	100328948(Tax:9986)	Chemical	Gene	metabolism|nmod|START_ENTITY Studies|nmod|metabolism Studies|nmod|preparation preparation|nmod|END_ENTITY	Studies of the metabolism of parathion with an apparently homogeneous preparation of rabbit liver cytochrome_P-450 .
6766135	0	parathion	77,86	cytochrome_P-450	35,51	parathion	cytochrome P-450	MESH:D010278	25251(Tax:10116)	Chemical	Gene	metabolism|nmod|START_ENTITY END_ENTITY|nmod|metabolism	Inactivation of purified rat liver cytochrome_P-450 during the metabolism of parathion -LRB- diethyl_p-nitrophenyl_phosphorothionate -RRB- .
755667	0	parathion	15,24	cytochrome_P-450	52,68	parathion	cytochrome P-450	MESH:D010278	25251(Tax:10116)	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of parathion and malathion with hepatic cytochrome_P-450 from rats treated with phenobarbital and carbon_disulfide .
6428710	2	parathyrin	257,267	Parathyrin	129,139	parathyrin	parathyrin	MESH:D010281	5741	Chemical	Gene	related|nmod|START_ENTITY related|nsubjpass|END_ENTITY	Parathyrin of Stannius corpuscles -LRB- PCS -RRB- , glands which are restricted to Holostei and Teleostei , is closely related to mammalian parathyrin -LRB- PTH -RRB- secreted by the parathyroids -LSB- -LRB- 6 -RSB- to -LSB- 9 -RSB- -RRB- .
15713945	0	parecoxib	38,47	COX-2	21,26	parecoxib	COX-2	MESH:C409945	4513	Chemical	Gene	inhibitors|xcomp|START_ENTITY inhibitors|nsubj|Complications Complications|nmod|END_ENTITY	Complications of the COX-2 inhibitors parecoxib and valdecoxib after cardiac surgery .
17687276	0	parecoxib	12,21	COX-2	39,44	parecoxib	COX-2	MESH:C409945	5743	Chemical	Gene	leads|nsubj|START_ENTITY leads|nmod|concentration concentration|compound|END_ENTITY	Intravenous parecoxib rapidly leads to COX-2 inhibitory concentration of valdecoxib in the central nervous system .
21964800	0	parecoxib	26,35	COX-2	48,53	parecoxib	COX-2	MESH:C409945	26198(Tax:10116)	Chemical	Gene	administration|nmod|START_ENTITY administration|appos|inhibitor inhibitor|compound|END_ENTITY	Delayed administration of parecoxib , a specific COX-2 inhibitor , attenuated postischemic neuronal apoptosis by phosphorylation Akt and GSK-3b .
23935760	0	parecoxib	41,50	COX-2	25,30	parecoxib	COX-2	MESH:C409945	26198(Tax:10116)	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|effects effects|nmod|END_ENTITY	Analgesic effects of the COX-2 inhibitor parecoxib on surgical pain through suppression of spinal ERK signaling .
19046861	0	parecoxib	13,22	cox-2	24,29	parecoxib	cox-2	MESH:C409945	4513	Chemical	Gene	Influence|nmod|START_ENTITY Influence|appos|inhibitor inhibitor|amod|END_ENTITY	Influence of parecoxib -LRB- cox-2 inhibitor -RRB- in experimental pleurodesis .
12198057	0	parecoxib	17,26	cyclooxygenase-2	41,57	parecoxib	cyclooxygenase-2	MESH:C409945	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	The influence of parecoxib , a parenteral cyclooxygenase-2 specific inhibitor , on the pharmacokinetics and clinical effects of midazolam .
15102535	0	parecoxib	27,36	cyclooxygenase-2	75,91	parecoxib	cyclooxygenase-2	MESH:C409945	5743	Chemical	Gene	profile|nmod|START_ENTITY profile|dep|novel novel|appos|inhibitor inhibitor|amod|END_ENTITY	Pharmacological profile of parecoxib : a novel , potent injectable selective cyclooxygenase-2 inhibitor .
16508400	0	parecoxib	55,64	cyclooxygenase-2	27,43	parecoxib	cyclooxygenase-2	MESH:C409945	5743	Chemical	Gene	inhibitors|xcomp|START_ENTITY inhibitors|nsubj|Safety Safety|nmod|END_ENTITY	Safety and efficacy of the cyclooxygenase-2 inhibitors parecoxib and valdecoxib after noncardiac surgery .
19095866	0	parecoxib	67,76	cyclooxygenase-2	29,45	parecoxib	cyclooxygenase-2	MESH:C409945	5743	Chemical	Gene	safety|amod|START_ENTITY safety|nmod|inhibitors inhibitors|amod|END_ENTITY	Cardiovascular safety of the cyclooxygenase-2 selective inhibitors parecoxib and valdecoxib in the postoperative setting : an analysis of integrated data .
22251854	0	parecoxib	41,50	cyclooxygenase-2	14,30	parecoxib	cyclooxygenase-2	MESH:C409945	29527(Tax:10116)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	The selective cyclooxygenase-2 inhibitor parecoxib markedly improves the ability of the duodenum to regulate luminal hypertonicity in anaesthetized rats .
14748383	0	parecoxib_sodium	71,87	COX-2	54,59	parecoxib sodium	COX-2	MESH:C409945	4513	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Efficacy and safety of the first parenteral selective COX-2 inhibitor , parecoxib_sodium , in adult patients with postoperative_pain .
1686901	0	pargylines	114,124	MAO-A	154,159	pargylines	MAO-A	null	4128	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Synthesis , biological evaluation and quantitative structure activity relationship analysis of nuclear-substituted pargylines as competitive inhibitors of MAO-A and MAO-B .
19342729	0	paricalcitol	14,26	osteoprotegerin	30,45	paricalcitol	osteoprotegerin	MESH:C084656	4982	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|production production|compound|END_ENTITY	The effect of paricalcitol on osteoprotegerin production by human peripheral blood mononuclear cells .
24745821	0	paricalcitol	65,77	vitamin_D_receptor	32,50	paricalcitol	vitamin D receptor	MESH:C084656	7421	Chemical	Gene	activation|nmod|START_ENTITY activation|nsubj|effects effects|nmod|END_ENTITY	Beneficial effects of selective vitamin_D_receptor activation by paricalcitol in chronic_kidney_disease .
26748501	0	paricalcitol	19,31	vitamin_D_receptor	57,75	paricalcitol	vitamin D receptor	MESH:C084656	7421	Chemical	Gene	activator|amod|START_ENTITY activator|compound|END_ENTITY	Comparison between paricalcitol and active non-selective vitamin_D_receptor activator for secondary_hyperparathyroidism in chronic_kidney_disease : a systematic review and meta-analysis of randomized controlled trials .
15993625	0	paroxetine	24,34	5-HT1A	57,63	paroxetine	5-HT1A	MESH:D017374	24473(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|binding binding|amod|END_ENTITY	Differential effects of paroxetine on raphe and cortical 5-HT1A binding : a PET study in monkeys .
27040795	0	paroxetine	72,82	5-HT1A	95,101	paroxetine	5-HT1A	MESH:D017374	24473(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|receptors receptors|nummod|END_ENTITY	Vilazodone does not inhibit sexual behavior in male rats in contrast to paroxetine : A role for 5-HT1A receptors ?
10676872	0	paroxetine	18,28	5-HT1B	42,48	paroxetine	5-HT1B	MESH:D017374	25075(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY treatment|nmod|END_ENTITY	Effect of chronic paroxetine treatment on 5-HT1B and 5-HT1D autoreceptors in rat dorsal raphe nucleus .
21930121	0	paroxetine	55,65	BDNF	81,85	paroxetine	BDNF	MESH:D017374	24225(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effects of GABAB ligands alone and in combination with paroxetine on hippocampal BDNF gene expression .
12412820	0	paroxetine	38,48	CYP2D6	17,23	paroxetine	CYP2D6	MESH:D017374	1565	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|Effect Effect|nmod|END_ENTITY	Effect of potent CYP2D6 inhibition by paroxetine on atomoxetine pharmacokinetics .
12584155	0	paroxetine	64,74	CYP2D6	45,51	paroxetine	CYP2D6	MESH:D017374	1565	Chemical	Gene	vitro|nmod|START_ENTITY END_ENTITY|acl|vitro	Apparent mechanism-based inhibition of human CYP2D6 in vitro by paroxetine : comparison with fluoxetine and quinidine .
15570195	0	paroxetine	88,98	CYP2D6	55,61	paroxetine	CYP2D6	MESH:D017374	1565	Chemical	Gene	alleles|xcomp|START_ENTITY alleles|nsubj|effects effects|nmod|END_ENTITY	Severe adverse effects in a newborn with two defective CYP2D6 alleles after exposure to paroxetine during late pregnancy .
15788540	0	paroxetine	57,67	CYP2D6	34,40	paroxetine	CYP2D6	MESH:D017374	24303(Tax:10116)	Chemical	Gene	inactivation|nmod|START_ENTITY inactivation|compound|END_ENTITY	In vitro-in vivo extrapolation of CYP2D6 inactivation by paroxetine : prediction of nonstationary pharmacokinetics and drug interaction magnitude .
16423440	0	paroxetine	62,72	CYP2D6	14,20	paroxetine	CYP2D6	MESH:D017374	1565	Chemical	Gene	concentration|nmod|START_ENTITY genotypes|nmod|concentration genotypes|nsubj|impact impact|nmod|END_ENTITY	The impact of CYP2D6 genotypes on the plasma concentration of paroxetine in Japanese psychiatric patients .
18641553	0	paroxetine	51,61	CYP2D6	0,6	paroxetine	CYP2D6	MESH:D017374	1565	Chemical	Gene	level|amod|START_ENTITY influence|nmod|level END_ENTITY|dep|influence	CYP2D6 and ABCB1 genetic variability : influence on paroxetine plasma level and therapeutic response .
20354688	0	paroxetine	39,49	CYP2D6	110,116	paroxetine	CYP2D6	MESH:D017374	1565	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|mydriasis mydriasis|nmod|O-demethylation O-demethylation|nmod|END_ENTITY	Two separate dose-dependent effects of paroxetine : mydriasis and inhibition of tramadol 's O-demethylation via CYP2D6 .
23357843	0	paroxetine	137,147	CYP2D6	68,74	paroxetine	CYP2D6	MESH:D017374	1565	Chemical	Gene	kinetics|nmod|START_ENTITY explain|dobj|kinetics explain|nsubj|model model|acl|incorporating incorporating|dobj|inactivation inactivation|nmod|END_ENTITY	Pharmacokinetic model incorporating mechanism-based inactivation of CYP2D6 can explain both non-linear kinetics and drug interactions of paroxetine .
23437966	0	paroxetine	49,59	CYP2D6	28,34	paroxetine	CYP2D6	MESH:D017374	1565	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|Dynamics Dynamics|nmod|END_ENTITY	Dynamics and persistence of CYP2D6 inhibition by paroxetine .
24868171	0	paroxetine	102,112	CYP2D6	23,29	paroxetine	CYP2D6	MESH:D017374	1565	Chemical	Gene	estimates|nmod|START_ENTITY estimates|nsubj|impact impact|nmod|END_ENTITY	Possible impact of the CYP2D6 * 10 polymorphism on the nonlinear pharmacokinetic parameter estimates of paroxetine in Japanese patients with major depressive_disorders .
24868171	9	paroxetine	1803,1813	CYP2D6	1714,1720	paroxetine	CYP2D6	MESH:D017374	1565	Chemical	Gene	estimates|nmod|START_ENTITY affect|dobj|estimates affect|nsubj|polymorphism polymorphism|compound|END_ENTITY	This is the first study to demonstrate that the CYP2D6 * 10 polymorphism could affect the nonlinear pharmacokinetic parameter estimates of paroxetine in Asian populations .
9617978	0	paroxetine	90,100	CYP2D6	58,64	paroxetine	CYP2D6	MESH:D017374	1565	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|Determinants Determinants|nmod|variability variability|nmod|END_ENTITY	Determinants of interindividual variability and extent of CYP2D6 and CYP1A2 inhibition by paroxetine and fluvoxamine in vivo .
25967538	0	paroxetine	80,90	Cytochrome_P450_2D6	0,19	paroxetine	Cytochrome P450 2D6	MESH:D017374	1565	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY affects|dobj|pharmacokinetics affects|nsubj|genotype genotype|amod|END_ENTITY	Cytochrome_P450_2D6 genotype affects the pharmacokinetics of controlled-release paroxetine in healthy Chinese subjects : comparison of traditional phenotype and activity score systems .
17853254	0	paroxetine	21,31	SERT	58,62	paroxetine	SERT	MESH:D017374	6532	Chemical	Gene	response|amod|START_ENTITY response|nmod|gene gene|amod|END_ENTITY	Association study of paroxetine therapeutic response with SERT gene polymorphisms in patients with major_depressive_disorder .
17459550	0	paroxetine	11,21	brain-derived_neurotrophic_factor	46,79	paroxetine	brain-derived neurotrophic factor	MESH:D017374	627	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of paroxetine or milnacipran on serum brain-derived_neurotrophic_factor in depressed patients .
19300599	0	paroxetine	130,140	brain-derived_neurotrophic_factor	19,52	paroxetine	brain-derived neurotrophic factor	MESH:D017374	627	Chemical	Gene	responding|xcomp|START_ENTITY patients|acl|responding Increase|nmod|patients Increase|nmod|levels levels|compound|END_ENTITY	Increase of plasma brain-derived_neurotrophic_factor levels in two psychotic_depressed patients responding to lithium addition to paroxetine treatment .
11673748	0	paroxetine	47,57	cytochrome_P4502D6	14,32	paroxetine	cytochrome P4502D6	MESH:D017374	1565	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Inhibition of cytochrome_P4502D6 activity with paroxetine normalizes the ultrarapid metabolizer phenotype as measured by nortriptyline pharmacokinetics and the debrisoquin test .
15910012	0	paroxetine	103,113	cytochrome_P450_2D6	16,35	paroxetine	cytochrome P450 2D6	MESH:D017374	1565	Chemical	Gene	use|nmod|START_ENTITY Contribution|dep|use Contribution|nmod|END_ENTITY	Contribution of cytochrome_P450_2D6 to 3,4-methylenedioxymethamphetamine disposition in humans : use of paroxetine as a metabolic inhibitor probe .
19743889	0	paroxetine	51,61	cytochrome_P450_2D6	10,29	paroxetine	cytochrome P450 2D6	MESH:D017374	1565	Chemical	Gene	concentrations|compound|START_ENTITY genotype|nmod|concentrations genotype|nsubj|Effect Effect|nmod|END_ENTITY	Effect of cytochrome_P450_2D6 genotype on maternal paroxetine plasma concentrations during pregnancy .
20435235	0	paroxetine	104,114	cytochrome_P450_2D6	131,150	paroxetine	cytochrome P450 2D6	MESH:D017374	1565	Chemical	Gene	Changes|nmod|START_ENTITY Changes|nmod|relation relation|nmod|genotype genotype|amod|END_ENTITY	Changes in the QTc interval after administration of flecainide_acetate , with and without coadministered paroxetine , in relation to cytochrome_P450_2D6 genotype : data from an open-label , two-period , single-sequence crossover study in healthy Korean male subjects .
19739695	0	paroxetine	11,21	low-density_lipoprotein_cholesterol	40,75	paroxetine	low-density lipoprotein cholesterol	MESH:D017374	22796	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of paroxetine and sertraline on low-density_lipoprotein_cholesterol : an observational cohort study .
18563559	0	paroxetine	11,21	serotonin_transporter	29,50	paroxetine	serotonin transporter	MESH:D017374	6532	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of paroxetine to the serotonin_transporter in membranes from different cells , subcellular fractions and species .
2143355	0	paroxetine	14,24	serotonin_transporter	56,77	paroxetine	serotonin transporter	MESH:D017374	6532	Chemical	Gene	START_ENTITY|xcomp|binding binding|nmod|END_ENTITY	High-affinity paroxetine binding to the human placental serotonin_transporter .
11128062	0	paroxetine	10,20	vasopressin	31,42	paroxetine	vasopressin	MESH:D017374	551	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of paroxetine on plasma vasopressin and water load testing in elderly individuals .
12516545	0	parthenolide	44,56	IL-4	68,72	parthenolide	IL-4	MESH:C002669	3565	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	The anti-inflammatory sesquiterpene_lactone parthenolide suppresses IL-4 gene expression in peripheral blood_T .
15256485	0	parthenolide	92,104	NF-kappaB	11,20	parthenolide	NF-kappaB	MESH:C002669	4790	Chemical	Gene	effect|nmod|START_ENTITY contribute|nmod|effect contribute|nsubj|END_ENTITY	Suppressed NF-kappaB and sustained JNK activation contribute to the sensitization effect of parthenolide to TNF-alpha-induced apoptosis in human cancer cells .
19397439	0	parthenolide	37,49	NF-kappaB	15,24	parthenolide	NF-kappaB	MESH:C002669	4790	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Suppression of NF-kappaB activity by parthenolide induces X-ray sensitivity through inhibition of split-dose repair in TP53 null prostate_cancer cells .
10874135	0	parthenolide	14,26	THP-1	149,154	parthenolide	THP-1	MESH:C002669	2736	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition by parthenolide of phorbol_ester-induced transcriptional activation of inducible_nitric_oxide_synthase gene in a human monocyte cell line THP-1 .
24432684	0	parthenolide	11,23	interleukin-1beta	48,65	parthenolide	interleukin-1beta	MESH:C002669	100008990(Tax:9986)	Chemical	Gene	START_ENTITY|nmod|expressions expressions|nmod|END_ENTITY	-LSB- Effect of parthenolide on serum expressions of interleukin-1beta and tumor_necrosis_factor-alpha in rabbits with knee_osteoarthritis -RSB- .
16447874	0	parthenolide	12,24	urokinase_type_plasminogen_activator	59,95	parthenolide	urokinase type plasminogen activator	MESH:C002669	5328	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	-LSB- Effects of parthenolide on the activity and expression of urokinase_type_plasminogen_activator in PGCL3 cells -RSB- .
11784715	0	paxillin	47,55	Hepatocyte_growth_factor	0,24	paxillin	Hepatocyte growth factor	null	15234(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Hepatocyte_growth_factor induces ERK-dependent paxillin phosphorylation and regulates paxillin-focal_adhesion_kinase association .
12853963	0	paxillin	19,27	JNK	0,3	paxillin	JNK	null	116554(Tax:10116)	Chemical	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	JNK phosphorylates paxillin and regulates cell migration .
16814769	0	paxillin	23,31	JNK	0,3	paxillin	JNK	null	26419(Tax:10090)	Chemical	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	JNK phosphorylation of paxillin , acting through the Rac1 and Cdc42 signaling cascade , mediates neurite extension in N1E-115 cells .
24890457	0	pazopanib	44,53	IL-2	19,23	pazopanib	IL-2	MESH:C516667	3558	Chemical	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	In vitro effect of IL-2 in combination with pazopanib or sunitinib on lymphocytes function and apoptosis of RCC cells .
20165696	0	pazopanib	77,86	VEGF	32,36	pazopanib	VEGF	MESH:C516667	7422	Chemical	Gene	treatment|nmod|START_ENTITY END_ENTITY|nmod|treatment	Noninvasive assessment of tumor VEGF receptors in response to treatment with pazopanib : a molecular imaging study .
24919855	0	pbi-05204	24,33	akt	68,71	pbi-05204	akt	null	207	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	First-in-human study of pbi-05204 , an oleander-derived inhibitor of akt , fgf-2 , nf-k and p70s6k , in patients with advanced solid tumors .
23387084	0	pefloxacin_mesylate	34,53	transferrin	67,78	pefloxacin mesylate	transferrin	MESH:D015366	7018	Chemical	Gene	START_ENTITY|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Molecular transport mechanism of pefloxacin_mesylate binding with transferrin -RSB- .
20616682	0	pegaptanib	75,85	vascular_endothelial_growth_factor	8,42	pegaptanib	vascular endothelial growth factor	MESH:C495058	7422	Chemical	Gene	injection|nmod|START_ENTITY END_ENTITY|nmod|injection	Aqueous vascular_endothelial_growth_factor after intravitreal injection of pegaptanib or ranibizumab in patients with age-related macular_degeneration .
26112013	0	pegylated_interferon-a	15,37	activin-A	89,98	pegylated interferon-a	activin-A	null	29200(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|concentrations concentrations|nmod|END_ENTITY	The effects of pegylated_interferon-a and ribavirin on liver and serum concentrations of activin-A and follistatin in normal Wistar rat : a preliminary report .
21914796	0	pendrin	15,22	CFTR	118,122	pendrin	CFTR	null	1080	Chemical	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	Novel role for pendrin in orchestrating bicarbonate secretion in cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- - expressing airway serous cells .
26752218	0	pendrin	85,92	SLC26A4	94,101	pendrin	SLC26A4	null	5172	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Reduction of cellular expression levels is a common feature of functionally affected pendrin -LRB- SLC26A4 -RRB- protein variants .
16505157	0	penetratin	86,96	nuclear_factor-kappaB	21,42	penetratin	nuclear factor-kappaB	null	4790	Chemical	Gene	effects|nmod|START_ENTITY effects|amod|END_ENTITY	In vitro and in vivo nuclear_factor-kappaB inhibitory effects of the cell-penetrating penetratin peptide .
2163628	0	penicillamine	37,50	myeloperoxidase	56,71	penicillamine	myeloperoxidase	MESH:D010396	4353	Chemical	Gene	Reaction|nmod|START_ENTITY Reaction|nmod|END_ENTITY	Reaction of autoxidation products of penicillamine with myeloperoxidase .
793510	0	penicillin	46,56	acylase	57,64	penicillin	acylase	MESH:D010406	95	Chemical	Gene	determination|nmod|START_ENTITY Method|nmod|determination END_ENTITY|nsubj|Method	-LSB- Method for the quantitative determination of penicillin acylase activity by the formation of phenylacetic_acid -RSB- .
12086049	0	penicillin	42,52	lactoferrin	10,21	penicillin	lactoferrin	MESH:D010406	280846(Tax:9913)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of lactoferrin in combination with penicillin on the morphology and the physiology of Staphylococcus_aureus isolated from bovine mastitis .
26452467	0	penicillin	81,91	tumor_necrosis_factor-alpha	42,69	penicillin	tumor necrosis factor-alpha	MESH:D010406	100009088(Tax:9986)	Chemical	Gene	release|nmod|START_ENTITY release|amod|END_ENTITY	Experimental study of cerebrospinal fluid tumor_necrosis_factor-alpha release in penicillin - and cephalosporin-resistant pneumococcal_meningitis treated with different antibiotic schedules .
11024451	0	penta-acetyl_geniposide	22,45	gamma-glutamyl_transpeptidase	68,97	penta-acetyl geniposide	gamma-glutamyl transpeptidase	MESH:C074968	116568(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|development development|nmod|END_ENTITY	Suppressive effect of penta-acetyl_geniposide on the development of gamma-glutamyl_transpeptidase foci-induced by aflatoxin_B -LRB- 1 -RRB- in rats .
12724925	0	pentachlorophenol	91,108	P53	15,18	pentachlorophenol	P53	MESH:D010416	7157	Chemical	Gene	exposed|xcomp|START_ENTITY exposed|nsubj|END_ENTITY	CYP1a1 , HSP70 , P53 , and c-fos expression in human liver_carcinoma cells -LRB- HepG2 -RRB- exposed to pentachlorophenol .
21967325	0	pentachlorophenol	15,32	polyphenol_oxidase	43,61	pentachlorophenol	polyphenol oxidase	MESH:D010416	102577727	Chemical	Gene	Degradation|nmod|START_ENTITY END_ENTITY|nsubj|Degradation	Degradation of pentachlorophenol by potato polyphenol_oxidase .
16462051	0	pentacyclic_triterpenes	49,72	ACAT-1	6,12	pentacyclic triterpenes	ACAT-1	MESH:D053978	38	Chemical	Gene	activities|nmod|START_ENTITY activities|amod|END_ENTITY	Human ACAT-1 and ACAT-2 inhibitory activities of pentacyclic_triterpenes from the leaves of Lycopus lucidus TURCZ .
16519515	0	pentadienyl	59,70	COX-1	107,112	pentadienyl	COX-1	null	4512	Chemical	Gene	complexes|amod|START_ENTITY complexes|nmod|END_ENTITY	Molecular dynamics simulations of arachidonic_acid-derived pentadienyl radical intermediate complexes with COX-1 and COX-2 : insights into oxygenation regio - and stereoselectivity .
10901706	0	pentafluorophenylsulfonamide	59,87	Glutathione_S-transferase	0,25	pentafluorophenylsulfonamide	Glutathione S-transferase	null	54486(Tax:10090)	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|amod|END_ENTITY	Glutathione_S-transferase metabolism of the antineoplastic pentafluorophenylsulfonamide in tissue culture and mice .
4165711	0	pentagastrin	42,54	Intrinsic-factor	0,16	pentagastrin	Intrinsic-factor	MESH:D010418	2694	Chemical	Gene	secretion|nmod|START_ENTITY secretion|amod|END_ENTITY	Intrinsic-factor secretion in response to pentagastrin .
8930176	0	pentagastrin	63,75	Secretin	0,8	pentagastrin	Secretin	MESH:D010418	483407(Tax:9615)	Chemical	Gene	inhibits|xcomp|START_ENTITY inhibits|nsubj|END_ENTITY	Secretin inhibits canine gastric acid secretion in response to pentagastrin by modulating gastric histamine release .
110504	0	pentagastrin	44,56	Thyrotrophin-releasing_hormone	0,30	pentagastrin	Thyrotrophin-releasing hormone	MESH:D010418	7200	Chemical	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Thyrotrophin-releasing_hormone inhibits the pentagastrin stimulated gastric secretion in man .
4435584	0	pentagastrin	15,27	cholecystokinin	51,66	pentagastrin	cholecystokinin	MESH:D010418	885	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of pentagastrin and the octapeptide of cholecystokinin on the human lower oesophageal sphincter .
3556418	0	pentagastrin	22,34	growth_hormone	38,52	pentagastrin	growth hormone	MESH:D010418	2688	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|compound|END_ENTITY	Stimulatory effect of pentagastrin on growth_hormone and prolactin secretion in normal subjects .
8128360	0	pentagastrin	74,86	vasoactive_intestinal_peptide	15,44	pentagastrin	vasoactive intestinal peptide	MESH:D010418	7432	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Stimulation Stimulation|nmod|END_ENTITY	Stimulation of vasoactive_intestinal_peptide and neurotensin secretion by pentagastrin in a patient with VIPoma_syndrome .
1362980	0	pentagastrin-stimulated_acid	59,87	Somatostatin	0,12	pentagastrin-stimulated acid	Somatostatin	null	24797(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY END_ENTITY|nmod|secretion	Somatostatin as a mediator of the effect of neurotensin on pentagastrin-stimulated_acid secretion in rats .
6793335	0	pentagastrin-stimulated_acid	53,81	gastric_inhibitory_polypeptide	11,41	pentagastrin-stimulated acid	gastric inhibitory polypeptide	null	2695	Chemical	Gene	secretion|amod|START_ENTITY inhibit|dobj|secretion Failure|acl|inhibit Failure|nmod|END_ENTITY	Failure of gastric_inhibitory_polypeptide to inhibit pentagastrin-stimulated_acid secretion in vagotomized human subjects .
7353457	0	pentagastrin-stimulated_acid	44,72	gastric_inhibitory_polypeptide	10,40	pentagastrin-stimulated acid	gastric inhibitory polypeptide	null	2695	Chemical	Gene	secretion|amod|START_ENTITY Effect|nmod|secretion Effect|nmod|END_ENTITY	Effect of gastric_inhibitory_polypeptide on pentagastrin-stimulated_acid secretion in man .
15735558	0	pentagastrin-stimulated_gastric_acid	19,55	TGF-beta3	0,9	pentagastrin-stimulated gastric acid	TGF-beta3	null	25717(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY inhibits|dobj|secretion inhibits|nsubj|END_ENTITY	TGF-beta3 inhibits pentagastrin-stimulated_gastric_acid secretion in rats .
3358763	0	pentagastrin-stimulated_gastric_acid	36,72	neurotensin	21,32	pentagastrin-stimulated gastric acid	neurotensin	null	299757(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY effect|nmod|secretion effect|nmod|END_ENTITY	Inhibitory effect of neurotensin on pentagastrin-stimulated_gastric_acid secretion in pylorus-ligated rats .
6151241	0	pentagastrin-stimulated_gastric_acid	26,62	somatostatin	10,22	pentagastrin-stimulated gastric acid	somatostatin	null	403993(Tax:9615)	Chemical	Gene	secretion|amod|START_ENTITY Effect|nmod|secretion Effect|nmod|END_ENTITY	Effect of somatostatin on pentagastrin-stimulated_gastric_acid secretion and gastric_antral_motility in dogs with gastric_fistula .
6822480	0	pentalenolactone	85,101	glyceraldehyde-3-phosphate_dehydrogenase	24,64	pentalenolactone	glyceraldehyde-3-phosphate dehydrogenase	MESH:C017996	2597	Chemical	Gene	producer|amod|START_ENTITY isoenzymes|nmod|producer isoenzymes|amod|END_ENTITY	Characterization of two glyceraldehyde-3-phosphate_dehydrogenase isoenzymes from the pentalenolactone producer Streptomyces arenae .
8204587	0	pentalenolactone	58,74	glyceraldehyde-3-phosphate_dehydrogenase	14,54	pentalenolactone	glyceraldehyde-3-phosphate dehydrogenase	MESH:C017996	100009074(Tax:9986)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of glyceraldehyde-3-phosphate_dehydrogenase by pentalenolactone .
15513897	0	pentamethoxystilbene	63,83	cytochrome_p-450_1A1	39,59	pentamethoxystilbene	cytochrome p-450 1A1	null	1543	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Potent inhibition of recombinant human cytochrome_p-450_1A1 by pentamethoxystilbene .
7695273	0	pentamidine	29,40	PNT1	24,28	pentamidine	PNT1	MESH:D010419	854440(Tax:4932)	Chemical	Gene	START_ENTITY|nsubj|Characterization Characterization|nmod|END_ENTITY	Characterization of the PNT1 pentamidine resistance gene of Saccharomyces_cerevisiae .
18346045	0	pentamidine	49,60	cytochrome_p450	22,37	pentamidine	cytochrome p450	MESH:D010419	4051	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|enzymes enzymes|amod|END_ENTITY	Inhibitory effects on cytochrome_p450 enzymes of pentamidine and its amidoxime pro-drug .
19158435	0	pentapeptide	34,46	Abeta	64,69	pentapeptide	Abeta	CHEBI:48545	54226(Tax:10116)	Chemical	Gene	protects|nsubj|START_ENTITY protects|nmod|END_ENTITY	An intraperitoneally administered pentapeptide protects against Abeta -LRB- 1-42 -RRB- induced neuronal_excitation in vivo .
2272748	0	pentapeptide	56,68	elastin	81,88	pentapeptide	elastin	CHEBI:48545	2006	Chemical	Gene	sequence|compound|START_ENTITY sequence|nmod|END_ENTITY	Conformation of a cyclic_decapeptide analog of a repeat pentapeptide sequence of elastin : cyclo-bis -LRB- valyl-prolyl-alanyl-valyl-glycyl -RRB- .
549433	0	pentapeptide	25,37	gastrin	41,48	pentapeptide	gastrin	CHEBI:48545	25320(Tax:10116)	Chemical	Gene	Metabolism|nmod|START_ENTITY Metabolism|nmod|END_ENTITY	Metabolism of C-terminal pentapeptide of gastrin in the rat .
2713873	0	pentasaccharide	93,108	antithrombin	118,130	pentasaccharide	antithrombin	CHEBI:35369	462	Chemical	Gene	START_ENTITY|nmod|III III|compound|END_ENTITY	Examination , by 1H-n.m.r. spectroscopy , of the binding of a synthetic , high-affinity heparin pentasaccharide to human antithrombin III .
15187451	0	pentazocine	66,77	P-glycoprotein	15,29	pentazocine	P-glycoprotein	MESH:D010423	287115(Tax:10116)	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of P-glycoprotein in blood-brain barrier transport of pentazocine in rats using brain uptake index method .
24561586	0	pentitol	37,45	Lat1	98,102	pentitol	Lat1	CHEBI:25899	855653(Tax:4932)	Chemical	Gene	transport|amod|START_ENTITY transport|nmod|END_ENTITY	Effect of C-terminal protein tags on pentitol and L-arabinose transport by Ambrosiozyma monospora Lat1 and Lat2 transporters in Saccharomyces_cerevisiae .
2842561	0	pentobarbital	54,67	Corticotropin-releasing_factor	0,30	pentobarbital	Corticotropin-releasing factor	MESH:D010424	81648(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY reverses|dobj|effect reverses|nsubj|END_ENTITY	Corticotropin-releasing_factor reverses the effect of pentobarbital through a_beta-noradrenergic mechanism in rats .
1642355	0	pentobarbital	21,34	c-fos	52,57	pentobarbital	c-fos	MESH:D010424	314322(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Selective effects of pentobarbital and halothane on c-fos and jun-B gene expression in rat brain .
3490296	0	pentobarbital	61,74	corticotropin-releasing_factor	27,57	pentobarbital	corticotropin-releasing factor	MESH:D010424	81648(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The antagonistic effect of corticotropin-releasing_factor on pentobarbital in rats .
2997306	0	pentopril	41,50	angiotensin-converting-enzyme	55,84	pentopril	angiotensin-converting-enzyme	MESH:C038810	1636	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effect of food on the bioavailability of pentopril , an angiotensin-converting-enzyme inhibitor , in healthy subjects .
3007583	0	pentopril	41,50	angiotensin-converting-enzyme	58,87	pentopril	angiotensin-converting-enzyme	MESH:C038810	1636	Chemical	Gene	Pharmacokinetics|nmod|START_ENTITY Pharmacokinetics|appos|inhibitor inhibitor|amod|END_ENTITY	Pharmacokinetics and pharmacodynamics of pentopril , a new angiotensin-converting-enzyme inhibitor in humans .
19804470	0	pentosan_polysulphate	89,110	PrP	24,27	pentosan polysulphate	PrP	null	5621	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|END_ENTITY	Less protease-resistant PrP in a patient with sporadic_CJD treated with intraventricular pentosan_polysulphate .
6209821	0	pentosan_polysulphate	104,125	antithrombin	79,91	pentosan polysulphate	antithrombin	null	462	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Identification of heparin cofactor II as the principal plasma cofactor for the antithrombin activity of pentosan_polysulphate -LRB- SP54 -RRB- .
1463749	0	pentose_phosphate	62,79	transketolase	28,41	pentose phosphate	transketolase	null	7086	Chemical	Gene	pathway|compound|START_ENTITY END_ENTITY|nmod|pathway	High control coefficient of transketolase in the nonoxidative pentose_phosphate pathway of human erythrocytes : NMR , antibody , and computer simulation studies .
20826743	0	pentose_phosphate	75,92	transketolase	51,64	pentose phosphate	transketolase	null	7086	Chemical	Gene	enzymes|compound|START_ENTITY enzymes|compound|END_ENTITY	Role of thiamine status and genetic variability in transketolase and other pentose_phosphate cycle enzymes in the progression of diabetic_nephropathy .
9593635	0	pentosidine	34,45	PDGF-B	72,78	pentosidine	PDGF-B	CHEBI:59951	5155	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	The advanced glycation endproduct pentosidine induces the expression of PDGF-B in human retinal pigment epithelial cells .
3877119	0	pentostatin	11,22	adenosine_deaminase	60,79	pentostatin	adenosine deaminase	MESH:D015649	24165(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Effects of pentostatin -LRB- 2 ` deoxycoformycin -RRB- , an inhibitor of adenosine_deaminase , on type II collagen-induced arthritis in rats .
7646420	0	pentostatin	46,57	adenosine_deaminase	10,29	pentostatin	adenosine deaminase	MESH:D015649	477236(Tax:9615)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|Effect Effect|nmod|END_ENTITY	Effect of adenosine_deaminase inhibition with pentostatin on myocardial_stunning in dogs .
7733907	0	pentostatin	93,104	adenosine_deaminase	21,40	pentostatin	adenosine deaminase	MESH:D015649	100	Chemical	Gene	resist|nmod|START_ENTITY forms|acl:relcl|resist END_ENTITY|nmod|forms	Mutagenesis of human adenosine_deaminase to active forms that partially resist inhibition by pentostatin .
1533232	0	pentoxifylline	15,29	ATPase	58,64	pentoxifylline	ATPase	MESH:D010431	1769	Chemical	Gene	effects|nmod|START_ENTITY membrane|nsubj|effects membrane|dobj|END_ENTITY	The effects of pentoxifylline on the plasma membrane Ca2 + ATPase in age-separated rat and human erythrocytes .
16566217	0	pentoxifylline	91,105	Bcl-2	23,28	pentoxifylline	Bcl-2	MESH:D010431	12043(Tax:10090)	Chemical	Gene	-RSB-|amod|START_ENTITY Expression|nmod|-RSB- Expression|nmod|END_ENTITY	-LSB- Expression of hepatic Bcl-2 and Bax proteins in schistosome-infected mice and the role of pentoxifylline -RSB- .
10778916	0	pentoxifylline	11,25	IL-1beta	64,72	pentoxifylline	IL-1beta	MESH:D010431	24494(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|nmod|END_ENTITY	Effects of pentoxifylline and nabumetone on the serum levels of IL-1beta and TNFalpha in rats with adjuvant_arthritis .
12693718	0	pentoxifylline	118,132	P-glycoprotein	80,94	pentoxifylline	P-glycoprotein	MESH:D010431	67078(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|amod|END_ENTITY	Carbonyl group of aliphatic side chain of pentoxifylline does not play role for P-glycoprotein antagonizing effect of pentoxifylline .
12693718	0	pentoxifylline	42,56	P-glycoprotein	80,94	pentoxifylline	P-glycoprotein	MESH:D010431	67078(Tax:10090)	Chemical	Gene	chain|nmod|START_ENTITY group|nmod|chain play|nsubj|group play|nmod|effect effect|amod|END_ENTITY	Carbonyl group of aliphatic side chain of pentoxifylline does not play role for P-glycoprotein antagonizing effect of pentoxifylline .
12568020	0	pentoxifylline	11,25	TGF-beta_1	55,65	pentoxifylline	TGF-beta 1	MESH:D010431	21803(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of pentoxifylline on the expression of hepatic TGF-beta_1 , type I and type III collagen in mice with liver_fibrosis due to Schistosoma_japonicum infection -RSB- .
18801959	3	pentoxifylline	504,518	TNF	445,448	pentoxifylline	TNF	MESH:D010431	103694380	Chemical	Gene	production|appos|START_ENTITY production|compound|END_ENTITY	Either soluble TNF receptor-1 or the general inhibitor of TNF production , pentoxifylline , was given to diminish TNF action on the first indication of cachexia .
2001073	6	pentoxifylline	806,820	TNF	791,794	pentoxifylline	TNF	MESH:D010431	7124	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	We also postulated that the TNF inhibitor , pentoxifylline -LRB- PTF -RRB- , would attenuate both GBS-induced TNF production and late GBS effects .
7578989	0	pentoxifylline	11,25	TNF	77,80	pentoxifylline	TNF	MESH:D010431	7124	Chemical	Gene	Effects|nmod|START_ENTITY neutrophil|nsubj|Effects neutrophil|xcomp|END_ENTITY	Effects of pentoxifylline on human polymorphonuclear neutrophil responses to TNF in whole blood .
7593465	4	pentoxifylline	646,660	TNF	694,697	pentoxifylline	TNF	MESH:D010431	7124	Chemical	Gene	Inhibitors|amod|START_ENTITY inhibited|nsubj|Inhibitors inhibited|dobj|accumulation accumulation|compound|END_ENTITY	Inhibitors of TNF synthesis , pentoxifylline -LRB- PTX -RRB- and thalidomide , inhibited TNF mRNA accumulation in LPS-activated monocytes and down-regulated DR mRNA but not DP or DQ mRNA .
12844341	0	pentoxifylline	38,52	TNF-alpha	14,23	pentoxifylline	TNF-alpha	MESH:D010431	24835(Tax:10116)	Chemical	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Inhibition of TNF-alpha production by pentoxifylline does not prevent endotoxin-induced decrease in serum IGF-I .
1385797	0	pentoxifylline	24,38	TNF-alpha	90,99	pentoxifylline	TNF-alpha	MESH:D010431	7124	Chemical	Gene	effects|nmod|START_ENTITY necrosis|nsubj|effects necrosis|dobj|factor-alpha factor-alpha|appos|END_ENTITY	Differential effects of pentoxifylline on the production of tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- and interleukin-6 -LRB- IL-6 -RRB- by monocytes and T cells .
15086397	0	pentoxifylline	71,85	TNF-alpha	119,128	pentoxifylline	TNF-alpha	MESH:D010431	7124	Chemical	Gene	alpha|amod|START_ENTITY alpha|appos|END_ENTITY	IgG1 antimycobacterial antibodies can reverse the inhibitory effect of pentoxifylline on tumour necrosis factor alpha -LRB- TNF-alpha -RRB- secreted by mycobacterial antigen-stimulated adherent cells .
17436095	0	pentoxifylline	11,25	TNF-alpha	29,38	pentoxifylline	TNF-alpha	MESH:D010431	7124	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|production production|amod|END_ENTITY	Effects of pentoxifylline on TNF-alpha production by peripheral blood mononuclear cells in patients with nonalcoholic_steatohepatitis .
17624531	0	pentoxifylline	125,139	TNF-alpha	19,28	pentoxifylline	TNF-alpha	MESH:D010431	21926(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY Role|dep|effect Role|nmod|cytokines cytokines|appos|END_ENTITY	Role of cytokines -LRB- TNF-alpha , IL-1beta and KC -RRB- in the pathogenesis of CPT-11-induced intestinal mucositis in mice : effect of pentoxifylline and thalidomide .
18297211	0	pentoxifylline	11,25	TNF-alpha	29,38	pentoxifylline	TNF-alpha	MESH:D010431	24835(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|histopathology histopathology|amod|END_ENTITY	Effects of pentoxifylline on TNF-alpha and lung histopathology in HCL-induced lung_injury .
18345460	0	pentoxifylline	112,126	TNF-alpha	14,23	pentoxifylline	TNF-alpha	MESH:D010431	21926(Tax:10090)	Chemical	Gene	treatment|amod|START_ENTITY inhibition|nmod|treatment influence|nmod|inhibition Importance|dep|influence Importance|nmod|END_ENTITY	Importance of TNF-alpha in the course of acute_infection with Trypanosoma_cruzi : influence of its inhibition by pentoxifylline treatment .
19373973	0	pentoxifylline	34,48	TNF-alpha	82,91	pentoxifylline	TNF-alpha	MESH:D010431	7124	Chemical	Gene	effect|nmod|START_ENTITY study|nmod|effect study|nmod|levels levels|nmod|END_ENTITY	Randomized study of the effect of pentoxifylline or octreotide on serum levels of TNF-alpha and IL-6 after endoscopic retrograde cholangiopancreatography .
8118639	0	pentoxifylline	10,24	TNF-alpha	78,87	pentoxifylline	TNF-alpha	MESH:D010431	7124	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|synthesis synthesis|acl|induced induced|nmod|END_ENTITY	Effect of pentoxifylline on the inhibition of surfactant synthesis induced by TNF-alpha in human type II pneumocytes .
8189599	0	pentoxifylline	95,109	TNF-alpha	130,139	pentoxifylline	TNF-alpha	MESH:D010431	7124	Chemical	Gene	TNF-alpha|nmod|START_ENTITY TNF-alpha|nmod|combination combination|nmod|END_ENTITY	Overcoming TNF-alpha and drug resistance of human renal_cell_carcinoma cells by treatment with pentoxifylline in combination with TNF-alpha or drugs : the role of TNF-alpha mRNA downregulation in tumor cell sensitization .
8189599	0	pentoxifylline	95,109	TNF-alpha	162,171	pentoxifylline	TNF-alpha	MESH:D010431	7124	Chemical	Gene	TNF-alpha|nmod|START_ENTITY TNF-alpha|dep|role role|nmod|downregulation downregulation|amod|END_ENTITY	Overcoming TNF-alpha and drug resistance of human renal_cell_carcinoma cells by treatment with pentoxifylline in combination with TNF-alpha or drugs : the role of TNF-alpha mRNA downregulation in tumor cell sensitization .
8660849	0	pentoxifylline	79,93	TNF-alpha	148,157	pentoxifylline	TNF-alpha	MESH:D010431	21926(Tax:10090)	Chemical	Gene	cells|amod|START_ENTITY production|nmod|cells regulation|nmod|production inhibits|nsubj|regulation inhibits|dobj|production production|nmod|END_ENTITY	The regulation of tumor_necrosis_factor-alpha production in murine mast cells : pentoxifylline or dexamethasone inhibits IgE-dependent production of TNF-alpha by distinct mechanisms .
9260111	0	pentoxifylline	139,153	Tumor_necrosis_factor-alpha	0,27	pentoxifylline	Tumor necrosis factor-alpha	MESH:D010431	7124	Chemical	Gene	affected|nmod|START_ENTITY affected|nsubjpass|release release|amod|END_ENTITY	Tumor_necrosis_factor-alpha and interleukin-6 release from white blood cells induced by different graft materials in vitro are affected by pentoxifylline and iloprost .
12021409	0	pentoxifylline	142,156	c-Jun	185,190	pentoxifylline	c-Jun	MESH:D010431	3725	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Selective down-regulation of c-jun gene expression by pentoxifylline and c-jun antisense interrupts platelet-derived growth factor signaling : pentoxifylline inhibits phosphorylation of c-Jun on serine 73 .
10678110	0	pentoxifylline	11,25	intercellular_adhesion_molecule-1	82,115	pentoxifylline	intercellular adhesion molecule-1	MESH:D010431	25464(Tax:10116)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|nmod|expression expression|amod|END_ENTITY	Effects of pentoxifylline and protein_kinase_C inhibitor on phorbol_ester-induced intercellular_adhesion_molecule-1 expression in brain microvascular endothelial cells .
16512644	0	pentoxifylline	26,40	intercellular_adhesion_molecule-1	62,95	pentoxifylline	intercellular adhesion molecule-1	MESH:D010431	25464(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|myocytes myocytes|amod|END_ENTITY	-LSB- Effects and mechanism of pentoxifylline on the expression of intercellular_adhesion_molecule-1 in the rat cardiac myocytes after lipopolysaccharide challenge -RSB- .
9330666	0	pentoxifylline	21,35	interferon_gamma	127,143	pentoxifylline	interferon gamma	MESH:D010431	3458	Chemical	Gene	effect|nmod|START_ENTITY induced|nsubj|effect induced|nmod|END_ENTITY	Inhibitory effect of pentoxifylline on HLA-DR expression and glycosaminoglycan synthesis of retrobulbar fibroblasts induced by interferon_gamma .
15701781	0	pentoxifylline	8,22	radiation-induced_fibrosis	55,81	pentoxifylline	radiation-induced fibrosis	MESH:D010431	54509	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of pentoxifylline and vitamin_E in attenuation of radiation-induced_fibrosis .
8699869	0	pentoxifylline	13,27	thrombomodulin	40,54	pentoxifylline	thrombomodulin	MESH:D010431	7056	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Influence of pentoxifylline on membrane thrombomodulin levels in endothelial cells submitted to hypoxic conditions .
7769305	0	pentoxifylline	10,24	tumor_necrosis_factor	62,83	pentoxifylline	tumor necrosis factor	MESH:D010431	7124	Chemical	Gene	START_ENTITY|dep|inhibition inhibition|nmod|production production|compound|END_ENTITY	High-dose pentoxifylline in patients with AIDS : inhibition of tumor_necrosis_factor production .
10762214	0	pentoxifylline	27,41	tumor_necrosis_factor-alpha	91,118	pentoxifylline	tumor necrosis factor-alpha	MESH:D010431	7124	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|involvement involvement|nmod|molecules molecules|compound|END_ENTITY	Immunomodulatory effect of pentoxifylline during human allograft rejection : involvement of tumor_necrosis_factor-alpha and adhesion molecules .
11451976	0	pentoxifylline	5,19	tumor_necrosis_factor-alpha	40,67	pentoxifylline	tumor necrosis factor-alpha	MESH:D010431	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|nmod|END_ENTITY	Oral pentoxifylline inhibits release of tumor_necrosis_factor-alpha from human peripheral blood monocytes : a potential treatment for aseptic_loosening_of_total_joint_components .
11505142	0	pentoxifylline	86,100	tumor_necrosis_factor-alpha	104,131	pentoxifylline	tumor necrosis factor-alpha	MESH:D010431	24835(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Activation of alveolar macrophages in acid-injured lung in rats : different effects of pentoxifylline on tumor_necrosis_factor-alpha and nitric_oxide production .
15025228	0	pentoxifylline	50,64	tumor_necrosis_factor-alpha	11,38	pentoxifylline	tumor necrosis factor-alpha	MESH:D010431	24835(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|inhibitors inhibitors|amod|END_ENTITY	Effects of tumor_necrosis_factor-alpha inhibitors pentoxifylline and thalidomide on alveolar bone_loss in short-term experimental periodontal disease in rats .
15447754	0	pentoxifylline	64,78	tumor_necrosis_factor-alpha	22,49	pentoxifylline	tumor necrosis factor-alpha	MESH:D010431	7124	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|effects effects|nmod|END_ENTITY	Beneficial effects of tumor_necrosis_factor-alpha inhibition by pentoxifylline on clinical , biochemical , and metabolic parameters of patients with nonalcoholic_steatohepatitis .
15727386	0	pentoxifylline	10,24	tumor_necrosis_factor-alpha	28,55	pentoxifylline	tumor necrosis factor-alpha	MESH:D010431	7124	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|amod|END_ENTITY	Effect of pentoxifylline on tumor_necrosis_factor-alpha and interleukin-6 levels in neonatal_sepsis .
8623512	0	pentoxifylline	168,182	tumor_necrosis_factor-alpha	89,116	pentoxifylline	tumor necrosis factor-alpha	MESH:D010431	7124	Chemical	Gene	role|nmod|START_ENTITY Characterization|dep|role Characterization|nmod|disseminated_intravascular_coagulation disseminated_intravascular_coagulation|nmod|relation relation|nmod|concentrations concentrations|amod|END_ENTITY	Characterization of cancer-related disseminated_intravascular_coagulation in relation to tumor_necrosis_factor-alpha blood concentrations : possible therapeutic role of pentoxifylline .
8660849	0	pentoxifylline	79,93	tumor_necrosis_factor-alpha	18,45	pentoxifylline	tumor necrosis factor-alpha	MESH:D010431	21926(Tax:10090)	Chemical	Gene	cells|amod|START_ENTITY production|nmod|cells production|amod|END_ENTITY	The regulation of tumor_necrosis_factor-alpha production in murine mast cells : pentoxifylline or dexamethasone inhibits IgE-dependent production of TNF-alpha by distinct mechanisms .
17692605	0	pentoxifylline	64,78	tumor_necrosis_factor_alpha	14,41	pentoxifylline	tumor necrosis factor alpha	MESH:D010431	24835(Tax:10116)	Chemical	Gene	transcription|nmod|START_ENTITY transcription|compound|END_ENTITY	Inhibition of tumor_necrosis_factor_alpha gene transcription by pentoxifylline reduces normothermic liver_ischemia-reperfusion injury in rats .
10986330	0	pentylenetetrazol	123,140	CA1	148,151	pentylenetetrazol	CA1	MESH:D010433	310218(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|region region|compound|END_ENTITY	Primed-burst potentiation occludes the potentiation phenomenon and enhances the epileptiform_activity induced by transient pentylenetetrazol in the CA1 region of rat hippocampal slices .
12480172	0	pentylenetetrazol	138,155	CA1	163,166	pentylenetetrazol	CA1	MESH:D010433	310218(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|region region|compound|END_ENTITY	Contribution of ionotropic glutamate receptors and voltage-dependent calcium channels to the potentiation phenomenon induced by transient pentylenetetrazol in the CA1 region of rat hippocampal slices .
26721354	0	pentylenetetrazole	74,92	G_protein-coupled_estrogen_receptor_1	25,62	pentylenetetrazole	G protein-coupled estrogen receptor 1	MESH:D010433	171104(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|END_ENTITY	Epileptogenic effects of G_protein-coupled_estrogen_receptor_1 in the rat pentylenetetrazole kindling model of epilepsy .
24548550	0	pentylenetetrazole	57,75	calcitonin	19,29	pentylenetetrazole	calcitonin	MESH:D010433	24241(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|effect effect|nmod|END_ENTITY	Positive effect of calcitonin on the seizures induced by pentylenetetrazole in rats .
10579203	0	pentylenetetrazole	114,132	microtubule-associated_protein_1B	24,57	pentylenetetrazole	microtubule-associated protein 1B	MESH:D010433	29456(Tax:10116)	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|expression expression|nmod|END_ENTITY	Anomalous expression of microtubule-associated_protein_1B in the hippocampus and cortex of aged rats treated with pentylenetetrazole .
22742962	0	pentylenetetrazole	48,66	serine_racemase	70,85	pentylenetetrazole	serine racemase	MESH:D010433	27364(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Decreased susceptibility to seizures induced by pentylenetetrazole in serine_racemase knockout mice .
2578769	0	peplomycin	86,96	PEP	98,101	peplomycin	PEP	MESH:D017663	5047	Chemical	Gene	administration|compound|START_ENTITY administration|appos|END_ENTITY	-LSB- Effects of bronchial artery infusion -LRB- B-AI -RRB- with single use of MMC after intravenous peplomycin -LRB- PEP -RRB- administration in lung_cancer -RSB- .
3316655	1	pepstatin	96,105	renin	126,131	pepstatin	renin	MESH:C031375	5972	Chemical	Gene	series|nmod|START_ENTITY potency|nmod|series analysis|nmod|potency analogues|nsubj|analysis analogues|nmod|END_ENTITY	Free-Wilson and correlation analysis of the inhibitory potency of a series of pepstatin analogues on plasma renin .
7034718	0	pepstatin	37,46	renin	4,9	pepstatin	renin	MESH:C031375	5972	Chemical	Gene	homologous|nmod|START_ENTITY homologous|nsubj|inhibitors inhibitors|compound|END_ENTITY	New renin inhibitors homologous with pepstatin .
2844592	0	pepstatin_A	14,25	pro-opiomelanocortin	47,67	pepstatin A	pro-opiomelanocortin	MESH:C031375	18976(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|inhibitor inhibitor|nmod|END_ENTITY	The effect of pepstatin_A , an inhibitor of the pro-opiomelanocortin -LRB- POMC -RRB- - converting enzyme , on POMC processing in mouse intermediate pituitary .
10937745	0	peptidyl_alpha-keto-beta-aldehydes	15,49	cathepsin_L	71,82	peptidyl alpha-keto-beta-aldehydes	cathepsin L	null	1514	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Development of peptidyl_alpha-keto-beta-aldehydes as new inhibitors of cathepsin_L -- comparisons of potency and selectivity profiles with cathepsin_B .
1732539	0	peptidyl_fluoromethyl_ketones	27,56	calpain	16,23	peptidyl fluoromethyl ketones	calpain	null	693249(Tax:9031)	Chemical	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of calpain by peptidyl_fluoromethyl_ketones .
20214639	0	peptidyl_prolyl	68,83	pin1	95,99	peptidyl prolyl	pin1	null	5300	Chemical	Gene	isomerase|amod|START_ENTITY isomerase|appos|END_ENTITY	Interaction and structural modification of topoisomerase IIalpha by peptidyl_prolyl isomerase , pin1 : an in silico study .
22474283	0	peptidylprolyl	24,38	FK506_binding_protein_8	0,23	peptidylprolyl	FK506 binding protein 8	null	23770	Chemical	Gene	activity|amod|START_ENTITY activity|nummod|END_ENTITY	FK506_binding_protein_8 peptidylprolyl isomerase activity manages a late stage of cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- folding and stability .
18397323	0	peptidylprolyl	54,68	PPWD1	80,85	peptidylprolyl	PPWD1	null	23398	Chemical	Gene	isomerase|amod|START_ENTITY isomerase|appos|END_ENTITY	The crystal structure of human WD40 repeat-containing peptidylprolyl isomerase -LRB- PPWD1 -RRB- .
21545152	0	peptidylprolyl	86,100	Pin1	112,116	peptidylprolyl	Pin1	null	5300	Chemical	Gene	isomerase|amod|START_ENTITY isomerase|appos|END_ENTITY	Discovery and characterization of a nonphosphorylated cyclic peptide inhibitor of the peptidylprolyl isomerase , Pin1 .
18924217	0	peptolides	4,14	leukocyte_elastase	99,117	peptolides	leukocyte elastase	null	1991	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	New peptolides from the cyanobacterium Nostoc insulare as selective and potent inhibitors of human leukocyte_elastase .
10362750	0	peptone	73,80	cholecystokinin	8,23	peptone	cholecystokinin	null	25298(Tax:10116)	Chemical	Gene	delivery|nmod|START_ENTITY produced|nmod|delivery produced|nsubj|Role Role|nmod|END_ENTITY	Role of cholecystokinin in the anorexia produced by duodenal delivery of peptone in rats .
12834856	0	peramivir	68,77	neuraminidase	32,45	peramivir	neuraminidase	MESH:C414210	4758	Chemical	Gene	confers|nmod|START_ENTITY confers|nsubj|mutation mutation|nmod|END_ENTITY	A point mutation in influenza B neuraminidase confers resistance to peramivir and loss of slow binding .
17703908	0	peramivir	85,94	neuraminidase	60,73	peramivir	neuraminidase	MESH:C414210	4758	Chemical	Gene	REMOVED|appos|START_ENTITY REMOVED|dep|properties properties|nmod|inhibitor inhibitor|compound|END_ENTITY	REMOVED : Physicochemical properties of the potent influenza neuraminidase inhibitor , peramivir -LRB- BCX-1812 -RRB- .
21722670	0	peramivir	46,55	neuraminidase	91,104	peramivir	neuraminidase	MESH:C414210	4758	Chemical	Gene	affinities|nmod|START_ENTITY Characterization|nmod|affinities Characterization|nmod|enzyme enzyme|amod|END_ENTITY	Characterization of the binding affinities of peramivir and oseltamivir_carboxylate to the neuraminidase enzyme .
22001088	0	peramivir	36,45	neuraminidase	86,99	peramivir	neuraminidase	MESH:C414210	4758	Chemical	Gene	derivative|nmod|START_ENTITY remains|nsubj|derivative remains|xcomp|inhibitor inhibitor|nmod|END_ENTITY	The de-guanidinylated derivative of peramivir remains a potent inhibitor of influenza neuraminidase .
22518184	0	peramivir	26,35	neuraminidase	61,74	peramivir	neuraminidase	MESH:C414210	4758	Chemical	Gene	START_ENTITY|nmod|comparison comparison|nmod|END_ENTITY	Clinical effectiveness of peramivir in comparison with other neuraminidase inhibitors in pediatric influenza patients .
14581727	0	perazine	44,52	cytochrome_P-450	11,27	perazine	cytochrome P-450	MESH:D010464	4051	Chemical	Gene	metabolism|amod|START_ENTITY Effects|nmod|metabolism Effects|nmod|inducers inducers|amod|END_ENTITY	Effects of cytochrome_P-450 inducers on the perazine metabolism in a primary culture of human hepatocytes .
16583240	0	perazine	33,41	interleukin-1_beta	72,90	perazine	interleukin-1 beta	MESH:D010464	24494(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|amod|END_ENTITY	Effect of chronic treatment with perazine on lipopolysaccharide-induced interleukin-1_beta levels in the rat brain .
17607730	0	perchlorate	11,22	sodium-iodide_symporter	26,49	perchlorate	sodium-iodide symporter	MESH:C494474	114479(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of perchlorate on sodium-iodide_symporter and pendrin gene expression in deer mice .
18713766	0	perfluoroalkyl_acids	82,102	peroxisome_proliferator-activated_receptor_alpha	30,78	perfluoroalkyl acids	peroxisome proliferator-activated receptor alpha	null	5465	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of mouse and human peroxisome_proliferator-activated_receptor_alpha by perfluoroalkyl_acids of different functional groups and chain lengths .
19359353	0	perfluorobutyrate	32,49	PPAR-alpha	78,88	perfluorobutyrate	PPAR-alpha	MESH:C033094	5465	Chemical	Gene	effects|nmod|START_ENTITY mediated|nsubj|effects mediated|nmod|END_ENTITY	Differential hepatic effects of perfluorobutyrate mediated by mouse and human PPAR-alpha .
26935986	0	perfluorocarbon	15,30	ICAM-1	34,40	perfluorocarbon	ICAM-1	null	3383	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|compound|END_ENTITY	The effects of perfluorocarbon on ICAM-1 expression in LPS-induced A549 cells and the potential mechanism .
3708015	0	perfluorodecalin	11,27	cytochrome_P-450	68,84	perfluorodecalin	cytochrome P-450	MESH:C008805	13079(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Effect of perfluorodecalin and perfluorotributylamine on the liver cytochrome_P-450 system -RSB- .
10965884	0	perfluorodecanoic_acid	28,50	peripheral-type_benzodiazepine_receptor	64,103	perfluorodecanoic acid	peripheral-type benzodiazepine receptor	MESH:C036567	24230(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	The peroxisome proliferator perfluorodecanoic_acid inhibits the peripheral-type_benzodiazepine_receptor -LRB- PBR -RRB- expression and hormone-stimulated mitochondrial cholesterol transport and steroid formation in Leydig cells .
26826296	0	perfluorohexanesulfonate	44,68	AMP-activated_protein_kinase	0,28	perfluorohexanesulfonate	AMP-activated protein kinase	MESH:C471071	78975(Tax:10116)	Chemical	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	AMP-activated_protein_kinase is involved in perfluorohexanesulfonate - induced apoptosis of neuronal cells .
20936102	0	perfluorononanoic_Acid	25,47	peroxisome_proliferator-activated_receptor-alpha	78,126	perfluorononanoic Acid	peroxisome proliferator-activated receptor-alpha	CHEBI:38397	19013(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY dependent|nsubj|effects dependent|nmod|END_ENTITY	Developmental effects of perfluorononanoic_Acid in the mouse are dependent on peroxisome_proliferator-activated_receptor-alpha .
23435180	0	perfluorooctanoic_acid	67,89	Bcrp	18,22	perfluorooctanoic acid	Bcrp	MESH:C023036	26357(Tax:10090)	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|expression expression|compound|END_ENTITY	Hepatic and renal Bcrp transporter expression in mice treated with perfluorooctanoic_acid .
25056757	0	perfluorooctanoic_acid	78,100	IL-2	111,115	perfluorooctanoic acid	IL-2	MESH:C023036	3558	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	In vitro evaluation of the effects of perfluorooctanesulfonic_acid -LRB- PFOS -RRB- and perfluorooctanoic_acid -LRB- PFOA -RRB- on IL-2 production in human T-cells .
22154759	0	perfluorooctanoic_acid	11,33	peroxisome_proliferator-activated_receptors	58,101	perfluorooctanoic acid	peroxisome proliferator-activated receptors	MESH:C023036	19013(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of perfluorooctanoic_acid -LRB- PFOA -RRB- on expression of peroxisome_proliferator-activated_receptors -LRB- PPAR -RRB- and nuclear receptor-regulated genes in fetal and postnatal CD-1 mouse tissues .
15004168	0	perforin	61,69	CD4	88,91	perforin	CD4	null	920	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Demethylation of promoter regulatory elements contributes to perforin overexpression in CD4 + lupus_T cells .
19290021	0	perforin	18,26	CD4	52,55	perforin	CD4	null	12504(Tax:10090)	Chemical	Gene	START_ENTITY|acl|regulating regulating|dobj|END_ENTITY	Novel function of perforin in negatively regulating CD4 -LRB- + -RRB- T cell activation by affecting calcium signaling .
15113754	0	perforin	45,53	CD56	71,75	perforin	CD56	null	4684	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	LFA-1 signaling through p44/42 is coupled to perforin degranulation in CD56 + CD8 + natural killer cells .
2471775	0	perforin	22,30	CD8	34,37	perforin	CD8	null	925	Chemical	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	In vivo expression of perforin by CD8 + lymphocytes during an acute viral_infection .
15113754	0	perforin	45,53	LFA-1	0,5	perforin	LFA-1	null	3683	Chemical	Gene	coupled|xcomp|START_ENTITY coupled|nsubjpass|END_ENTITY	LFA-1 signaling through p44/42 is coupled to perforin degranulation in CD56 + CD8 + natural killer cells .
10516878	0	pergolide	49,58	dopamine_D2_receptor	16,36	pergolide	dopamine D2 receptor	MESH:D010479	1813	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Modification of dopamine_D2_receptor activity by pergolide in Parkinson 's _ disease : an in vivo study by PET .
7158225	0	pergolide	53,62	prolactin	30,39	pergolide	prolactin	MESH:D010479	5617	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|secretion secretion|compound|END_ENTITY	Potent 48 hours inhibition of prolactin secretion by pergolide in hyperprolactinaemic women .
17875193	0	perhexiline	52,63	CYP2D6	67,73	perhexiline	CYP2D6	MESH:D010480	1565	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY pharmacokinetics|nmod|metabolizers metabolizers|nummod|END_ENTITY	Steady-state pharmacokinetics of the enantiomers of perhexiline in CYP2D6 poor and extensive metabolizers administered Rac-perhexiline .
23912246	0	perifosine	21,31	AEG-1	0,5	perifosine	AEG-1	MESH:C105905	92140	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	AEG-1 is a target of perifosine and is over-expressed in gastric_dysplasia and cancers .
21775054	0	perifosine	21,31	AKT	122,125	perifosine	AKT	MESH:C105905	207	Chemical	Gene	Co-administration|nmod|START_ENTITY induces|nsubj|Co-administration induces|dobj|apoptosis apoptosis|nmod|cells cells|dep|inhibition inhibition|compound|END_ENTITY	Co-administration of perifosine with paclitaxel synergistically induces apoptosis in ovarian_cancer cells : more than just AKT inhibition .
22253088	0	perifosine	55,65	AKT	41,44	perifosine	AKT	MESH:C105905	207	Chemical	Gene	START_ENTITY|nsubj|consequences consequences|nmod|treatment treatment|nmod|inhibitor inhibitor|compound|END_ENTITY	Metabolic consequences of treatment with AKT inhibitor perifosine in breast_cancer cells .
23863122	1	perifosine	285,295	AKT	188,191	perifosine	AKT	MESH:C105905	207	Chemical	Gene	induced|nmod|START_ENTITY cytotoxicity|acl|induced evaluated|nmod|cytotoxicity evaluated|nmod|importance importance|nmod|chronic_lymphocytic_leukemia chronic_lymphocytic_leukemia|compound|END_ENTITY	Abstract Because of the importance of the phosphoinositide_3-kinase -LRB- PI3K -RRB- / AKT pathway in chronic_lymphocytic_leukemia -LRB- CLL -RRB- , we evaluated in vitro cytotoxicity induced by perifosine , an AKT inhibitor , in CLL lymphocytes and found that the mean 50 % effective dose -LRB- ED50 -RRB- was 313 nM .
17604333	0	perifosine	22,32	Akt	102,105	perifosine	Akt	MESH:C105905	207	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|apoptosis apoptosis|nmod|cells cells|acl|requiring requiring|dobj|inhibition inhibition|nmod|END_ENTITY	The alkylphospholipid perifosine induces apoptosis of human lung_cancer cells requiring inhibition of Akt and activation of the extrinsic apoptotic pathway .
17928881	0	perifosine	77,87	Akt	63,66	perifosine	Akt	MESH:C105905	207	Chemical	Gene	START_ENTITY|nsubj|activity activity|nmod|inhibitor inhibitor|compound|END_ENTITY	Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor perifosine in acute_myelogenous_leukemia cells .
18385752	0	perifosine	25,35	Akt	10,13	perifosine	Akt	MESH:C105905	207	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	The novel Akt inhibitor , perifosine , induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism .
20103671	0	perifosine	87,97	Akt	73,76	perifosine	Akt	MESH:C105905	207	Chemical	Gene	START_ENTITY|nsubj|studies studies|nmod|trial trial|nmod|inhibitor inhibitor|compound|END_ENTITY	Clinical and translational studies of a phase II trial of the novel oral Akt inhibitor perifosine in relapsed or relapsed/refractory Waldenstrom 's _ macroglobulinemia .
22674198	0	perifosine	46,56	Akt	32,35	perifosine	Akt	MESH:C105905	207	Chemical	Gene	START_ENTITY|nsubj|trials trials|nmod|inhibitor inhibitor|compound|END_ENTITY	Two phase 2 trials of the novel Akt inhibitor perifosine in patients with advanced renal_cell_carcinoma after progression on vascular_endothelial_growth_factor-targeted therapy .
25740692	0	perifosine	70,80	Akt	55,58	perifosine	Akt	MESH:C105905	207	Chemical	Gene	pharmacokinetics|appos|START_ENTITY pharmacokinetics|nmod|inhibitor inhibitor|compound|END_ENTITY	Plasma and cerebrospinal fluid pharmacokinetics of the Akt inhibitor , perifosine , in a non-human primate model .
26097873	1	perifosine	128,138	Akt	113,116	perifosine	Akt	MESH:C105905	207	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	The Akt inhibitor , perifosine , enhances the sorafenib-induced cytotoxicity against bladder_cancer cells .
23588929	0	perifosine	117,127	eIF4E	108,113	perifosine	eIF4E	MESH:C105905	1977	Chemical	Gene	targeting|nmod|START_ENTITY targeting|dobj|END_ENTITY	Upregulation of the eIF4E signaling pathway contributes to the progression of gastric_cancer , and targeting eIF4E by perifosine inhibits cell growth .
10800878	0	perindopril	51,62	ACE	35,38	perindopril	ACE	MESH:D020913	1636	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|appos|END_ENTITY	The angiotensin converting enzyme -LRB- ACE -RRB- inhibitor , perindopril , modifies the clinical features of Parkinson 's _ disease .
12240792	0	perindopril	61,72	ACE	0,3	perindopril	ACE	MESH:D020913	1636	Chemical	Gene	switching|xcomp|START_ENTITY inhibitors|parataxis|switching inhibitors|nsubj|END_ENTITY	ACE inhibitors in heart_failure -- switching from enalapril to perindopril .
1282386	0	perindopril	107,118	ACE	87,90	perindopril	ACE	MESH:D020913	100715217	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Endocrine and hemodynamic responses to dopamine infusion in the guinea-pig : effects of ACE inhibition with perindopril .
15673060	0	perindopril	11,22	ACE	142,145	perindopril	ACE	MESH:D020913	1636	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|function function|nmod|patients patients|nmod|hypertension hypertension|nmod|relation relation|nmod|angiotensin_converting_enzyme angiotensin_converting_enzyme|appos|END_ENTITY	Effects of perindopril treatment on hemostatic function in patients with essential hypertension in relation to angiotensin_converting_enzyme -LRB- ACE -RRB- and plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- gene polymorphisms .
16279041	0	perindopril	26,37	ACE	12,15	perindopril	ACE	MESH:D020913	1636	Chemical	Gene	Use|amod|START_ENTITY Use|nmod|inhibitor inhibitor|compound|END_ENTITY	-LSB- Use of the ACE inhibitor perindopril in patients with chronic_obstructive_lung_diseases , complicated by cor_pulmonale -RSB- .
16793747	0	perindopril	61,72	ACE	46,49	perindopril	ACE	MESH:D020913	1636	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|Effects Effects|nmod|enzyme enzyme|appos|END_ENTITY	Effects of the angiotensin-converting enzyme -LRB- ACE -RRB- inhibitor perindopril on endothelial and platelet functions in essential hypertension .
17140552	0	perindopril	20,31	ACE	0,3	perindopril	ACE	MESH:D020913	1636	Chemical	Gene	function|amod|START_ENTITY inhibition|nmod|function inhibition|nsubj|END_ENTITY	ACE inhibition with perindopril and endothelial function .
17953470	0	perindopril	41,52	ACE	0,3	perindopril	ACE	MESH:D020913	1636	Chemical	Gene	focus|nmod|START_ENTITY inhibition|dep|focus inhibition|compound|END_ENTITY	ACE inhibition in hypertension : focus on perindopril .
18219959	0	perindopril	83,94	ACE	69,72	perindopril	ACE	MESH:D020913	1636	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- The therapy of complicated forms of essential hypertension with the ACE inhibitor perindopril -RSB- .
18931896	0	perindopril	97,108	ACE	46,49	perindopril	ACE	MESH:D020913	1636	Chemical	Gene	reduction|nmod|START_ENTITY explain|nsubj|reduction explain|dep|prevention prevention|nmod|coronary_disease coronary_disease|nmod|inhibition inhibition|compound|END_ENTITY	Secondary prevention of coronary_disease with ACE inhibition -- does blood pressure reduction with perindopril explain the benefits in EUROPA ?
18950770	0	perindopril	20,31	ACE	0,3	perindopril	ACE	MESH:D020913	1636	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	ACE inhibition with perindopril and biomarkers of atherosclerosis and thrombosis : results from the PERTINENT study .
20573778	0	perindopril	76,87	ACE	61,64	perindopril	ACE	MESH:D020913	1636	Chemical	Gene	inhibitor|dep|START_ENTITY inhibitor|compound|END_ENTITY	The effect of treatment based on a diuretic -LRB- indapamide -RRB- + / - ACE inhibitor -LRB- perindopril -RRB- on fractures in the Hypertension in the Very Elderly Trial -LRB- HYVET -RRB- .
2219962	0	perindopril	53,64	ACE	103,106	perindopril	ACE	MESH:D020913	1636	Chemical	Gene	pathways|nmod|START_ENTITY comparison|nmod|pathways inhibitor|nsubj|comparison inhibitor|nsubj|angiotensin-converting_enzyme angiotensin-converting_enzyme|appos|END_ENTITY	Interspecies comparison of the metabolic pathways of perindopril , a new angiotensin-converting_enzyme -LRB- ACE -RRB- inhibitor .
2407491	0	perindopril	38,49	ACE	20,23	perindopril	ACE	MESH:D020913	24310(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|effects effects|nmod|END_ENTITY	Vascular effects of ACE inhibition by perindopril .
7571476	0	perindopril	40,51	ACE	69,72	perindopril	ACE	MESH:D020913	1636	Chemical	Gene	effectiveness|nmod|START_ENTITY effectiveness|appos|inhibitor inhibitor|compound|END_ENTITY	-LSB- 24-hour effectiveness and tolerance of perindopril -LRB- Prestarium -RRB- , an ACE inhibitor , in the treatment of mild to moderate hypertension .
8343488	0	perindopril	20,31	ACE	0,3	perindopril	ACE	MESH:D020913	613133(Tax:9823)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|END_ENTITY	ACE inhibition with perindopril and atherogenesis-induced structural and functional changes in minipig arteries .
8527353	0	perindopril	103,114	ACE	26,29	perindopril	ACE	MESH:D020913	1636	Chemical	Gene	comparison|nmod|START_ENTITY hypertension|appos|comparison inhibitor|nmod|hypertension inhibitor|nsubj|acceptability acceptability|nmod|END_ENTITY	Clinical acceptability of ACE inhibitor therapy in mild to moderate hypertension , a comparison between perindopril and enalapril .
9503533	0	perindopril	105,116	ACE	165,168	perindopril	ACE	MESH:D020913	1636	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|-RSB- -RSB-|appos|END_ENTITY	-LSB- Change of circadian pattern of arterial pressure in patients with congestive_heart_failure treated with perindopril , an inhibitor of angiotensin-converting_enzyme -LRB- ACE -RRB- -RSB- .
15723572	0	perindopril	82,93	Angiotensin-converting_enzyme	0,29	perindopril	Angiotensin-converting enzyme	MESH:D020913	1636	Chemical	Gene	evidence|nmod|START_ENTITY inhibition|dep|evidence inhibition|amod|END_ENTITY	Angiotensin-converting_enzyme inhibition in cardiovascular_disease : evidence with perindopril .
19303575	0	perindopril	46,57	Angiotensin-converting_enzyme	0,29	perindopril	Angiotensin-converting enzyme	MESH:D020913	1636	Chemical	Gene	revascularization|amod|START_ENTITY inhibition|nmod|revascularization inhibition|amod|END_ENTITY	Angiotensin-converting_enzyme inhibition with perindopril in patients with prior myocardial_infarction and/or revascularization : a subgroup analysis of the EUROPA trial .
19379059	0	perindopril	44,55	Angiotensin-converting_enzyme	0,29	perindopril	Angiotensin-converting enzyme	MESH:D020913	1636	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Angiotensin-converting_enzyme inhibition by perindopril in the treatment of cardiovascular_disease .
15619341	0	perindopril	12,23	TGF_beta_1	59,69	perindopril	TGF beta 1	MESH:D020913	59086(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of perindopril and valsartan on the expression of TGF_beta_1 and TGF beta receptor II mRNA , Smad3 and Smad7 in experimental hepatic fibrotic rats -RSB- .
15449186	0	perindopril	57,68	angiotensin-I_converting_enzyme	15,46	perindopril	angiotensin-I converting enzyme	MESH:D020913	1636	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Effects of the angiotensin-I_converting_enzyme inhibitor perindopril on tumor growth and angiogenesis in head_and_neck_squamous_cell_carcinoma cells .
11085284	0	perindopril	54,65	angiotensin-converting_enzyme	14,43	perindopril	angiotensin-converting enzyme	MESH:D020913	1636	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|inhibitor inhibitor|amod|END_ENTITY	Effect of the angiotensin-converting_enzyme inhibitor perindopril on haemostasis in essential hypertension .
15024568	0	perindopril	55,66	angiotensin-converting_enzyme	15,44	perindopril	angiotensin-converting enzyme	MESH:D020913	100009274(Tax:9986)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Effects of the angiotensin-converting_enzyme inhibitor perindopril on endothelial injury and hemostasis in rabbit endotoxic_shock .
15256675	0	perindopril	50,61	angiotensin-converting_enzyme	10,39	perindopril	angiotensin-converting enzyme	MESH:D020913	1636	Chemical	Gene	therapy|amod|START_ENTITY inhibitor|dep|therapy inhibitor|amod|END_ENTITY	Long-term angiotensin-converting_enzyme inhibitor perindopril therapy improves cerebral perfusion reserve in patients with previous minor stroke .
15572274	0	perindopril	50,61	angiotensin-converting_enzyme	10,39	perindopril	angiotensin-converting enzyme	MESH:D020913	11421(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|inhibitor inhibitor|amod|END_ENTITY	Effect of angiotensin-converting_enzyme inhibitor perindopril on interneurons in MPTP-treated mice .
1580274	0	perindopril	101,112	angiotensin-converting_enzyme	57,86	perindopril	angiotensin-converting enzyme	MESH:D020913	1636	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Long-term reduction of microalbuminuria after 3 years of angiotensin-converting_enzyme inhibition by perindopril in hypertensive insulin-treated diabetic patients .
16881230	0	perindopril	102,113	angiotensin-converting_enzyme	62,91	perindopril	angiotensin-converting enzyme	MESH:D020913	1636	Chemical	Gene	START_ENTITY|nsubj|efficiency efficiency|nmod|therapy therapy|nmod|inhibitor inhibitor|amod|END_ENTITY	-LSB- Clinical efficiency of course and long-term therapy with the angiotensin-converting_enzyme inhibitor perindopril in patients with chronic_obstructive_lung_disease and cor_pulmonale -RSB- .
20627092	0	perindopril	70,81	angiotensin-converting_enzyme	29,58	perindopril	angiotensin-converting enzyme	MESH:D020913	11421(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Effect of a centrally active angiotensin-converting_enzyme inhibitor , perindopril , on cognitive performance in a mouse model of Alzheimer 's _ disease .
21256058	0	perindopril	104,115	angiotensin-converting_enzyme	63,92	perindopril	angiotensin-converting enzyme	MESH:D020913	24310(Tax:10116)	Chemical	Gene	inhibitor|dep|START_ENTITY inhibitor|amod|END_ENTITY	Downregulation of remodelling enzymatic activity induced by an angiotensin-converting_enzyme inhibitor -LRB- perindopril -RRB- reduces the degeneration of experimental abdominal_aortic_aneurysms in a rat model .
2176982	0	perindopril	99,110	angiotensin-converting_enzyme	15,44	perindopril	angiotensin-converting enzyme	MESH:D020913	1636	Chemical	Gene	evoked|nmod|START_ENTITY evoked|nsubj|Involvement Involvement|nmod|inhibition inhibition|amod|END_ENTITY	Involvement of angiotensin-converting_enzyme inhibition in reversal of helpless behavior evoked by perindopril in rats .
2219962	0	perindopril	53,64	angiotensin-converting_enzyme	72,101	perindopril	angiotensin-converting enzyme	MESH:D020913	1636	Chemical	Gene	pathways|nmod|START_ENTITY comparison|nmod|pathways inhibitor|nsubj|comparison inhibitor|nsubj|END_ENTITY	Interspecies comparison of the metabolic pathways of perindopril , a new angiotensin-converting_enzyme -LRB- ACE -RRB- inhibitor .
2231339	0	perindopril	67,78	angiotensin-converting_enzyme	26,55	perindopril	angiotensin-converting enzyme	MESH:D020913	1636	Chemical	Gene	inhibitor|dep|START_ENTITY inhibitor|amod|END_ENTITY	Radioimmunoassay of a new angiotensin-converting_enzyme inhibitor -LRB- perindopril -RRB- in human plasma and urine : advantages of coupling anion-exchange column chromatography with radioimmunoassay .
2467090	0	perindopril	11,22	angiotensin-converting_enzyme	33,62	perindopril	angiotensin-converting enzyme	MESH:D020913	24310(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Effects of perindopril on tissue angiotensin-converting_enzyme activity demonstrated by quantitative in vitro autoradiography .
25518516	0	perindopril	90,101	angiotensin-converting_enzyme	28,57	perindopril	angiotensin-converting enzyme	MESH:D020913	1636	Chemical	Gene	-RSB-|amod|START_ENTITY features|nmod|-RSB- Principles|dep|features Principles|nmod|choice choice|nmod|inhibitor inhibitor|amod|END_ENTITY	-LSB- Principles of choice of an angiotensin-converting_enzyme inhibitor : specific features of perindopril -RSB- .
2847068	0	perindopril	92,103	angiotensin-converting_enzyme	13,42	perindopril	angiotensin-converting enzyme	MESH:D020913	24310(Tax:10116)	Chemical	Gene	administration|nmod|START_ENTITY brain|nmod|administration inhibition|nmod|brain inhibition|amod|END_ENTITY	Differential angiotensin-converting_enzyme inhibition in brain after oral administration of perindopril demonstrated by quantitative in vitro autoradiography .
9125666	0	perindopril	73,84	angiotensin-converting_enzyme	40,69	perindopril	angiotensin-converting enzyme	MESH:D020913	100009274(Tax:9986)	Chemical	Gene	Acute|nmod|START_ENTITY Acute|nmod|inhibition inhibition|nmod|END_ENTITY	Acute and chronic in vivo inhibition of angiotensin-converting_enzyme by perindopril in the endothelium and adventitia of large arteries and organs of the rabbit .
9503533	0	perindopril	105,116	angiotensin-converting_enzyme	134,163	perindopril	angiotensin-converting enzyme	MESH:D020913	1636	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Change of circadian pattern of arterial pressure in patients with congestive_heart_failure treated with perindopril , an inhibitor of angiotensin-converting_enzyme -LRB- ACE -RRB- -RSB- .
9867068	0	perindopril	56,67	angiotensin-converting_enzyme	10,39	perindopril	angiotensin-converting enzyme	MESH:D020913	1636	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Effect of angiotensin-converting_enzyme inhibition with perindopril and beta-blockade with atenolol on retinal blood flow in hypertensive diabetic subjects .
2043313	0	perindopril	57,68	angiotensin_I_converting_enzyme	15,46	perindopril	angiotensin I converting enzyme	MESH:D020913	24310(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Effects of the angiotensin_I_converting_enzyme inhibitor perindopril on cerebral blood flow in awake hypertensive rats .
1311597	0	perindopril	24,35	angiotensin_converting_enzyme	61,90	perindopril	angiotensin converting enzyme	MESH:D020913	1636	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY END_ENTITY|nsubj|pharmacokinetics	The pharmacokinetics of perindopril and its effects on serum angiotensin_converting_enzyme activity in hypertensive patients with chronic_renal_failure .
15673060	0	perindopril	11,22	angiotensin_converting_enzyme	111,140	perindopril	angiotensin converting enzyme	MESH:D020913	1636	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|function function|nmod|patients patients|nmod|hypertension hypertension|nmod|relation relation|nmod|END_ENTITY	Effects of perindopril treatment on hemostatic function in patients with essential hypertension in relation to angiotensin_converting_enzyme -LRB- ACE -RRB- and plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- gene polymorphisms .
2185055	0	perindopril	100,111	angiotensin_converting_enzyme	56,85	perindopril	angiotensin converting enzyme	MESH:D020913	1636	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|reduction reduction|nmod|microalbuminuria microalbuminuria|nmod|year year|nmod|END_ENTITY	Long term reduction of microalbuminuria after 1 year of angiotensin_converting_enzyme inhibition by perindopril in hypertensive insulin-treated diabetic patients .
3030762	0	perindopril	113,124	angiotensin_converting_enzyme	73,102	perindopril	angiotensin converting enzyme	MESH:D020913	1636	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|treatment treatment|nmod|month month|nmod|inhibitor inhibitor|amod|END_ENTITY	The haemodynamic and humoral effects of treatment for one month with the angiotensin_converting_enzyme inhibitor perindopril in salt replete hypertensive patients .
9426847	0	perindopril	54,65	angiotensin_converting_enzyme	10,39	perindopril	angiotensin converting enzyme	MESH:D020913	1636	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|Effect Effect|nmod|END_ENTITY	Effect of angiotensin_converting_enzyme inhibition by perindopril on proteinuria of primary renal_diseases .
23906395	0	perindopril	12,23	aquaporin-2	48,59	perindopril	aquaporin-2	MESH:D020913	25386(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of perindopril on expression of kidney aquaporin-2 and urine aquaporin-2 excretion in chronic_heart_failure rats -RSB- .
23906395	0	perindopril	12,23	aquaporin-2	70,81	perindopril	aquaporin-2	MESH:D020913	25386(Tax:10116)	Chemical	Gene	excretion|amod|START_ENTITY excretion|amod|END_ENTITY	-LSB- Effects of perindopril on expression of kidney aquaporin-2 and urine aquaporin-2 excretion in chronic_heart_failure rats -RSB- .
15604340	0	perindopril	125,136	plasminogen_activator_inhibitor_1	30,63	perindopril	plasminogen activator inhibitor 1	MESH:D020913	24617(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Reduced cardiac expression of plasminogen_activator_inhibitor_1 and transforming_growth_factor_beta1 in obese Zucker rats by perindopril .
21104642	0	perindopril	14,25	resistin	50,58	perindopril	resistin	MESH:D020913	56729	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|levels levels|compound|END_ENTITY	The effect of perindopril and enalapril on plasma resistin levels in normotensive patients with coronary_heart_disease .
26414930	0	periodontium	51,63	Wnt3a	14,19	periodontium	Wnt3a	null	303181(Tax:10116)	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of Wnt3a , Wnt10b , b-catenin and DKK1 in periodontium during orthodontic tooth movement in rats .
14642103	0	periodontium	72,84	fibromodulin	52,64	periodontium	fibromodulin	null	2331	Chemical	Gene	-RSB-|compound|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- Immunohistochemical localization and expression of fibromodulin in the periodontium -RSB- .
12377622	0	periodontium	68,80	interleukin-1beta	32,49	periodontium	interleukin-1beta	null	24494(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Effect of loss of bite force on interleukin-1beta expression in rat periodontium .
24872678	0	periplocin	81,91	P-glycoprotein	0,14	periplocin	P-glycoprotein	MESH:C502381	5243	Chemical	Gene	transport|nmod|START_ENTITY transport|amod|END_ENTITY	P-glycoprotein - and organic anion-transporting polypeptide-mediated transport of periplocin may lead to drug-herb/drug-drug interactions .
14575646	0	permethrin	110,120	dopamine_transporter	39,59	permethrin	dopamine transporter	MESH:D026023	13162(Tax:10090)	Chemical	Gene	up-regulation|nmod|START_ENTITY up-regulation|nmod|END_ENTITY	Differential up-regulation of striatal dopamine_transporter and alpha-synuclein by the pyrethroid insecticide permethrin .
20349050	0	perospirone	34,45	Dopamine_D2_receptor	0,20	perospirone	Dopamine D2 receptor	MESH:C065533	1813	Chemical	Gene	occupancy|nmod|START_ENTITY occupancy|amod|END_ENTITY	Dopamine_D2_receptor occupancy by perospirone : a positron emission tomography study in patients with schizophrenia and healthy subjects .
10462181	0	perospirone	11,22	Fos	69,72	perospirone	Fos	MESH:C065533	314322(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of perospirone , a novel 5-HT2 and D2 receptor antagonist , on Fos protein expression in the rat forebrain .
18478216	0	perospirone	39,50	P-glycoprotein	54,68	perospirone	P-glycoprotein	MESH:C065533	5243	Chemical	Gene	START_ENTITY|nmod|function function|amod|END_ENTITY	Effect of the novel antipsychotic drug perospirone on P-glycoprotein function and expression in Caco-2 cells .
19386475	0	perospirone	10,21	P300	25,29	perospirone	P300	MESH:C065533	2033	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Effect of perospirone on P300 electrophysiological activity and social cognition in schizophrenia : a three-dimensional analysis with sloreta .
8758777	0	peroxidate	42,52	endothelin-1	19,31	peroxidate	endothelin-1	null	1906	Chemical	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	-LSB- Changes in plasma endothelin-1 and lipid peroxidate levels and amount of superoxidate dismutase in red blood cell in patients with pregnancy-induced hypertension -RSB- .
9247609	0	peroxide	26,34	CPT-11	10,16	peroxide	CPT-11	CHEBI:44785	963084(Tax:115711)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of CPT-11 on lipid peroxide level in mouse tissues .
25108358	0	peroxide	16,24	Hsp70	0,5	peroxide	Hsp70	CHEBI:44785	3308	Chemical	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	Hsp70 and lipid peroxide levels following heat stress in Xeropicta derbentina -LRB- Krynicki 1836 -RRB- -LRB- Gastropoda , Pulmonata -RRB- with regard to different colour morphs .
12635575	0	peroxide	22,30	Interleukin-2	0,13	peroxide	Interleukin-2	CHEBI:44785	3558	Chemical	Gene	production|amod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Interleukin-2 induces peroxide production by primed normodense eosinophils of patients with asthma .
22906720	0	peroxide	22,30	S-formylglutathione_hydrolase	59,88	peroxide	S-formylglutathione hydrolase	CHEBI:44785	853377(Tax:4932)	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	A role for His-160 in peroxide inhibition of S. _ cerevisiae S-formylglutathione_hydrolase : evidence for an oxidation sensitive motif .
7536845	0	peroxide	70,78	cytochrome_P-450	30,46	peroxide	cytochrome P-450	CHEBI:44785	25251(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	Effect of orpiment -LRB- As2S3 -RRB- on cytochrome_P-450 , glutathione and lipid peroxide levels of rat liver .
6888166	0	peroxide	20,28	cytochrome_p-450	72,88	peroxide	cytochrome p-450	CHEBI:44785	4051	Chemical	Gene	START_ENTITY|nmod|compounds compounds|acl:relcl|bind bind|advcl|END_ENTITY	Inhibition of lipid peroxide decomposition by compounds which bind with cytochrome_p-450 .
9655189	0	peroxide	11,19	endothelial_nitric_oxide_synthase	23,56	peroxide	endothelial nitric oxide synthase	CHEBI:44785	397557(Tax:9823)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of peroxide on endothelial_nitric_oxide_synthase in coronary arteries .
11535888	0	peroxide	68,76	tumor_necrosis_factor-alpha	20,47	peroxide	tumor necrosis factor-alpha	CHEBI:44785	7124	Chemical	Gene	production|compound|START_ENTITY production|amod|END_ENTITY	CXCR2 regulation of tumor_necrosis_factor-alpha adherence-dependent peroxide production is significantly diminished after severe injury in human neutrophils .
10569633	5	peroxides	1037,1046	IFN-gamma	1002,1011	peroxides	IFN-gamma	MESH:D010545	3458	Chemical	Gene	induction|nmod|START_ENTITY END_ENTITY|nmod|induction	This revealed that IL-1 and LPS did not induce any increase in the amount of intracellular peroxides by themselves , but they primed IFN-gamma for maximal induction of peroxides .
3975871	0	peroxides	40,49	antithrombin_III	14,30	peroxides	antithrombin III	MESH:D010545	462	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of antithrombin_III by lipid peroxides .
2308398	0	peroxides	75,84	catalase	50,58	peroxides	catalase	MESH:D010545	847	Chemical	Gene	inactivation|nmod|START_ENTITY inactivation|amod|END_ENTITY	Glutathione peroxidase , superoxide dismutase , and catalase inactivation by peroxides and oxygen derived free radicals .
10588361	0	peroxides	74,83	thioredoxin	103,114	peroxides	thioredoxin	MESH:D010545	7295	Chemical	Gene	START_ENTITY|nmod|presence presence|nmod|END_ENTITY	Characterization of three isoforms of mammalian peroxiredoxin that reduce peroxides in the presence of thioredoxin .
42250	0	peroxy	151,157	cytochrome_P-450	129,145	peroxy	cytochrome P-450	CHEBI:29369	4051	Chemical	Gene	compounds|amod|START_ENTITY END_ENTITY|nmod|compounds	Mechanistic studies with purified components of the liver microsomal hydroxylation system : spectral intermediates in reaction of cytochrome_P-450 with peroxy compounds .
2241988	0	peroxyacetic_acid	22,39	catalase	10,18	peroxyacetic acid	catalase	MESH:D010463	847	Chemical	Gene	Action|nmod|START_ENTITY Action|nmod|END_ENTITY	Action of catalase on peroxyacetic_acid .
16298689	0	peroxynitrite	151,164	Bcl-2	8,13	peroxynitrite	Bcl-2	MESH:D030421	596	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Role Role|nmod|END_ENTITY	Role of Bcl-2 in the arachidonate-mediated survival signaling preventing mitochondrial permeability transition-dependent U937 cell necrosis induced by peroxynitrite .
10342486	0	peroxynitrite	119,132	Insulin	0,7	peroxynitrite	Insulin	MESH:D030421	3630	Chemical	Gene	START_ENTITY|nsubj|secretion secretion|compound|END_ENTITY	Insulin secretion , DNA damage , and apoptosis in human and rat islets of Langerhans following exposure to nitric_oxide , peroxynitrite , and cytokines .
24937218	9	peroxynitrite	1269,1282	Lpg2965	1294,1301	peroxynitrite	Lpg1809	MESH:D030421	3078221(Tax:272624)	Chemical	Gene	reductase|amod|START_ENTITY reductase|appos|END_ENTITY	In contrast , a peptidoglycan-associated lipoprotein -LRB- Lpg2043 -RRB- and a peroxynitrite reductase -LRB- Lpg2965 -RRB- were accumulated by biofilm cells .
17854826	0	peroxynitrite	78,91	Matrix_metalloproteinase-2	0,26	peroxynitrite	Matrix metalloproteinase-2	MESH:D030421	81686(Tax:10116)	Chemical	Gene	myocardial_injury|amod|START_ENTITY alpha-actinin|nmod|myocardial_injury degrades|dobj|alpha-actinin degrades|nsubj|END_ENTITY	Matrix_metalloproteinase-2 degrades the cytoskeletal protein alpha-actinin in peroxynitrite mediated myocardial_injury .
19464362	0	peroxynitrite	33,46	Myeloperoxidase	0,15	peroxynitrite	Myeloperoxidase	MESH:D030421	4353	Chemical	Gene	interaction|nmod|START_ENTITY interaction|amod|END_ENTITY	Myeloperoxidase interaction with peroxynitrite : chloride deficiency and heme depletion .
12960242	0	peroxynitrite	77,90	NF-kappaB	120,129	peroxynitrite	NF-kappaB	MESH:D030421	4790	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Nicotine induces human neutrophils to produce IL-8 through the generation of peroxynitrite and subsequent activation of NF-kappaB .
25547066	0	peroxynitrite	97,110	SERCA1	85,91	peroxynitrite	SERCA1	MESH:D030421	487	Chemical	Gene	injury|amod|START_ENTITY END_ENTITY|nmod|injury	Rutin stimulates sarcoplasmic reticulum Ca -LRB- 2 + -RRB- - ATPase activity -LRB- SERCA1 -RRB- and protects SERCA1 from peroxynitrite mediated injury .
11892711	0	peroxynitrite	12,25	cyclooxygenase-2	29,45	peroxynitrite	cyclooxygenase-2	MESH:D030421	5743	Chemical	Gene	role|nmod|START_ENTITY role|nmod|expression expression|amod|END_ENTITY	The role of peroxynitrite in cyclooxygenase-2 expression of rheumatoid_synovium .
19733148	0	peroxynitrite	49,62	cystathionine_beta-synthase	16,43	peroxynitrite	cystathionine beta-synthase	MESH:D030421	875	Chemical	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of cystathionine_beta-synthase with peroxynitrite .
10585458	0	peroxynitrite	4,17	cytochrome_c_oxidase	40,60	peroxynitrite	cytochrome c oxidase	MESH:D030421	282199(Tax:9913)	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	The peroxynitrite reductase activity of cytochrome_c_oxidase involves a two-electron redox reaction at the heme_a -LRB- 3 -RRB- - Cu -LRB- B -RRB- site .
12107173	0	peroxynitrite	14,27	endothelial_nitric_oxide_synthase	98,131	peroxynitrite	endothelial nitric oxide synthase	MESH:D030421	287024(Tax:9913)	Chemical	Gene	START_ENTITY|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Modulation by peroxynitrite of Akt - and AMP-activated kinase-dependent Ser1179 phosphorylation of endothelial_nitric_oxide_synthase .
11530836	0	peroxynitrite	10,23	glutaredoxin	27,39	peroxynitrite	glutaredoxin	MESH:D030421	64045(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of peroxynitrite on glutaredoxin .
11901182	0	peroxynitrite	56,69	iNOS	32,36	peroxynitrite	iNOS	MESH:D030421	18126(Tax:10090)	Chemical	Gene	generation|amod|START_ENTITY results|nmod|generation results|nsubj|overexpression overexpression|nmod|END_ENTITY	Cardiomyocyte overexpression of iNOS in mice results in peroxynitrite generation , heart_block , and sudden_death .
18289732	0	peroxynitrite	31,44	iNOS	130,134	peroxynitrite	iNOS	MESH:D030421	24599(Tax:10116)	Chemical	Gene	generation|amod|START_ENTITY induced|dobj|generation MAPK|acl|induced Activation|nmod|MAPK rat|nsubj|Activation rat|dobj|astrocytes astrocytes|nmod|activation activation|nmod|END_ENTITY	Activation of p38 MAPK induced peroxynitrite generation in LPS plus IFN-gamma-stimulated rat primary astrocytes via activation of iNOS and NADPH oxidase .
8864843	3	peroxynitrite	574,587	iNOS	666,670	peroxynitrite	HO-1	MESH:D030421	15368(Tax:10090)	Chemical	Gene	synthesis|amod|START_ENTITY activation|nmod|synthesis accompanied|nsubjpass|activation accompanied|nmod|activation activation|nmod|END_ENTITY	Results showed that activation of peroxynitrite synthesis in macrophages was accompanied by the transcriptional activation of iNOS and HO-1 genes .
9915669	0	peroxynitrite	61,74	iNOS	23,27	peroxynitrite	iNOS	MESH:D030421	24599(Tax:10116)	Chemical	Gene	level|compound|START_ENTITY decreases|dobj|level decreases|nsubj|inhibition inhibition|nmod|END_ENTITY	Specific inhibition of iNOS decreases the intestinal mucosal peroxynitrite level and improves the barrier function after thermal_injury .
17121419	0	peroxynitrite	51,64	insulin	40,47	peroxynitrite	insulin	MESH:D030421	3630	Chemical	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of the nitration site of insulin by peroxynitrite .
15026147	0	peroxynitrite	36,49	matrix_metalloproteinase-2	100,126	peroxynitrite	matrix metalloproteinase-2	MESH:D030421	282872(Tax:9913)	Chemical	Gene	exchanger|nmod|START_ENTITY exchanger|dep|role role|nmod|END_ENTITY	Inhibition of Na + / Ca2 + exchanger by peroxynitrite in microsomes of pulmonary smooth muscle : role of matrix_metalloproteinase-2 .
19046943	0	peroxynitrite	65,78	matrix_metalloproteinase-2	35,61	peroxynitrite	matrix metalloproteinase-2	MESH:D030421	4313	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation and modulation of 72kDa matrix_metalloproteinase-2 by peroxynitrite and glutathione .
8394811	0	peroxynitrite	36,49	myeloperoxidase	15,30	peroxynitrite	myeloperoxidase	MESH:D030421	4353	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of myeloperoxidase with peroxynitrite .
15663195	0	peroxynitrite	53,66	plasmin	70,77	peroxynitrite	plasmin	MESH:D030421	5340	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Peroxynitrite and fibrinolytic system : the effect of peroxynitrite on plasmin activity .
26234576	0	peroxynitrite	53,66	plasmin	83,90	peroxynitrite	plasmin	MESH:D030421	5340	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activity activity|compound|END_ENTITY	Peroxynitrite and fibrinolytic system-The effects of peroxynitrite on t-PA-induced plasmin activity .
11728807	0	peroxynitrite	14,27	soluble_guanylyl_cyclase	57,81	peroxynitrite	soluble guanylyl cyclase	MESH:D030421	25206(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|nmod|END_ENTITY	The effect of peroxynitrite on the catalytic activity of soluble_guanylyl_cyclase .
12033457	0	peroxynitrite	54,67	thioredoxin_reductase	13,34	peroxynitrite	thioredoxin reductase	MESH:D030421	25824	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Induction of thioredoxin_reductase gene expression by peroxynitrite in human umbilical vein endothelial cells .
15184375	0	peroxynitrite	66,79	thioredoxin_reductase	132,153	peroxynitrite	thioredoxin reductase	MESH:D030421	25824	Chemical	Gene	oxidation|nmod|START_ENTITY oxidation|dep|modulation modulation|nmod|kinetics kinetics|nmod|system system|amod|END_ENTITY	Cysteine oxidation of tau and microtubule-associated_protein-2 by peroxynitrite : modulation of microtubule assembly kinetics by the thioredoxin_reductase system .
8641430	0	peroxynitrite	59,72	tissue_inhibitor_of_metalloproteinase-1	16,55	peroxynitrite	tissue inhibitor of metalloproteinase-1	MESH:D030421	7076	Chemical	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of tissue_inhibitor_of_metalloproteinase-1 by peroxynitrite .
1208573	0	perphenazine	51,63	Prolactin	0,9	perphenazine	Prolactin	MESH:D010546	24683(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY synthesis|dep|effects synthesis|compound|END_ENTITY	Prolactin and growth_hormone synthesis : effects of perphenazine , alpha-methyltyrosine and estrogen in different thyroid states .
3617	0	perphenazine	32,44	Prolactin	0,9	perphenazine	Prolactin	MESH:D010546	24683(Tax:10116)	Chemical	Gene	test|nmod|START_ENTITY test|compound|END_ENTITY	Prolactin stimulation test with perphenazine : an evaluation of plasma prolactin levels and pituitary secretory activity in the rat .
3717195	0	perphenazine	42,54	Prolactin	0,9	perphenazine	Prolactin	MESH:D010546	5617	Chemical	Gene	responses|acl|START_ENTITY responses|compound|END_ENTITY	Prolactin and blood pressure responses to perphenazine in human subjects : comparison of the oral and intramuscular routes .
3795197	0	perphenazine	22,34	Prolactin	0,9	perphenazine	Prolactin	MESH:D010546	5617	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Prolactin response to perphenazine .
18075468	0	perphenazine	113,125	prolactin	91,100	perphenazine	prolactin	MESH:D010546	5617	Chemical	Gene	impact|advcl|START_ENTITY impact|dobj|sensitivity sensitivity|nmod|response response|compound|END_ENTITY	CYP2D6 and DRD2 genes differentially impact pharmacodynamic sensitivity and time course of prolactin response to perphenazine .
3617	0	perphenazine	32,44	prolactin	70,79	perphenazine	prolactin	MESH:D010546	24683(Tax:10116)	Chemical	Gene	test|nmod|START_ENTITY test|dep|evaluation evaluation|nmod|levels levels|compound|END_ENTITY	Prolactin stimulation test with perphenazine : an evaluation of plasma prolactin levels and pituitary secretory activity in the rat .
7120089	0	perphenazine	78,90	prolactin	6,15	perphenazine	prolactin	MESH:D010546	5617	Chemical	Gene	forms|amod|START_ENTITY administration|nmod|forms subjects|nmod|administration increase|nmod|subjects increase|compound|END_ENTITY	Serum prolactin level increase in normal subjects following administration of perphenazine oral dosage forms : possible application to bioavailability testing .
10087000	0	petrosaspongiolide_M	11,31	phospholipase_A2	41,57	petrosaspongiolide M	phospholipase A2	MESH:C118309	18780(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effects of petrosaspongiolide_M , a novel phospholipase_A2 inhibitor , on acute_and_chronic_inflammation .
12325001	0	petrosaspongiolide_M	50,70	phospholipase_A2	19,35	petrosaspongiolide M	phospholipase A2	MESH:C118309	406141(Tax:7460)	Chemical	Gene	basis|nmod|START_ENTITY basis|nmod|inhibition inhibition|amod|END_ENTITY	Molecular basis of phospholipase_A2 inhibition by petrosaspongiolide_M .
25522543	0	phellopterin	50,62	ERK	34,37	phellopterin	ERK	MESH:C104601	5594	Chemical	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	Stimulation of phosphorylation of ERK and CREB by phellopterin and auraptene isolated from Citrusjunos .
3104258	0	phenacetin	24,34	cytochrome_P-450	71,87	phenacetin	cytochrome P-450	MESH:D010615	25251(Tax:10116)	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Metabolic activation of phenacetin and phenetidine by several forms of cytochrome_P-450 purified from liver microsomes of rats and hamsters .
18051539	0	phenazopyridine_hydrochloride	41,70	albumin	88,95	phenazopyridine hydrochloride	albumin	MESH:D010621	213	Chemical	Gene	-RSB-|amod|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Spectroscopic studies on the binding of phenazopyridine_hydrochloride and bovine serum albumin -RSB- .
22227609	0	phencyclidine	32,45	5-HT1A	12,18	phencyclidine	5-HT1A	MESH:D010622	24473(Tax:10116)	Chemical	Gene	receptors|nmod|START_ENTITY receptors|nummod|END_ENTITY	The role of 5-HT1A receptors in phencyclidine -LRB- PCP -RRB- - induced novel object recognition -LRB- NOR -RRB- deficit in rats .
3621046	0	phencyclidine	26,39	CA1	55,58	phencyclidine	CA1	MESH:D010622	100720116	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|neurons neurons|compound|END_ENTITY	Dose-dependent effects of phencyclidine on hippocampal CA1 neurons .
25689573	0	phencyclidine	97,110	D-aspartate_oxidase	11,30	phencyclidine	D-aspartate oxidase	MESH:D010622	70503(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|role role|nmod|END_ENTITY	A role for D-aspartate_oxidase in schizophrenia and in schizophrenia-related symptoms induced by phencyclidine in mice .
18615569	0	phencyclidine	72,85	GLT-1	0,5	phencyclidine	GLT-1	MESH:D010622	29482(Tax:10116)	Chemical	Gene	increased|nmod|START_ENTITY increased|nsubjpass|expression expression|compound|END_ENTITY	GLT-1 expression and Glu uptake in rat cerebral cortex are increased by phencyclidine .
8440313	0	phencyclidine	11,24	MK-801_and_1	26,38	phencyclidine	MK-801 and 1	MESH:D010622	171436(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|amod|END_ENTITY	Effects of phencyclidine , MK-801_and_1 ,3 - di -LRB- 2-tolyl -RRB- guanidine on non-dopaminergic midbrain neurons .
11814421	0	phencyclidine	97,110	MS-153	10,16	phencyclidine	MS-153	MESH:D010622	3207684(Tax:155537)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of MS-153 on the development of behavioral sensitization to stereotypy-inducing effect of phencyclidine .
11875629	0	phencyclidine	110,123	MS-153	10,16	phencyclidine	MS-153	MESH:D010622	3207684(Tax:155537)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of MS-153 on the development of behavioral sensitization to locomotion - and ataxia-inducing effects of phencyclidine .
16800825	0	phencyclidine	29,42	brain-derived_neurotrophic_factor	46,79	phencyclidine	brain-derived neurotrophic factor	MESH:D010622	24225(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Different effects of chronic phencyclidine on brain-derived_neurotrophic_factor in neonatal and adult rat brains .
16903871	0	phencyclidine	127,140	brain-derived_neurotrophic_factor	10,43	phencyclidine	brain-derived neurotrophic factor	MESH:D010622	24225(Tax:10116)	Chemical	Gene	induced|xcomp|START_ENTITY up-regulation|acl|induced up-regulation|compound|END_ENTITY	Sustained brain-derived_neurotrophic_factor up-regulation and sensorimotor gating abnormality induced by postnatal exposure to phencyclidine : comparison with adult treatment .
26736083	0	phencyclidine	116,129	brain-derived_neurotrophic_factor	14,47	phencyclidine	brain-derived neurotrophic factor	MESH:D010622	24225(Tax:10116)	Chemical	Gene	administration|nmod|START_ENTITY retrosplenial|dobj|administration retrosplenial|nsubj|Expression Expression|nmod|mRNA mRNA|amod|END_ENTITY	Expression of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- mRNA in rat retrosplenial cortex following administration of phencyclidine .
9262187	0	phencyclidine	92,105	cyclooxygenase-2	14,30	phencyclidine	cyclooxygenase-2	MESH:D010622	29527(Tax:10116)	Chemical	Gene	administration|nmod|START_ENTITY retrosplenial|dobj|administration retrosplenial|nsubj|Expression Expression|nmod|mRNA mRNA|amod|END_ENTITY	Expression of cyclooxygenase-2 mRNA in rat retrosplenial cortex following administration of phencyclidine .
2891481	0	phencyclidine	76,89	cytochrome_P-450	30,46	phencyclidine	cytochrome P-450	MESH:D010622	100328948(Tax:9986)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Mechanism-based inhibition of cytochrome_P-450 by heterocyclic analogues of phencyclidine .
24345457	0	phencyclidine	73,86	dopamine_D1_receptor	109,129	phencyclidine	dopamine D1 receptor	MESH:D010622	13488(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nmod|activation activation|nmod|END_ENTITY	Clozapine ameliorates epigenetic and behavioral_abnormalities induced by phencyclidine through activation of dopamine_D1_receptor .
3837860	0	phencyclidine	11,24	met-enkephalin	71,85	phencyclidine	met-enkephalin	MESH:D010622	18976(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of phencyclidine in combination with morphine on the levels of met-enkephalin , dopamine , DOPAC and HVA in discrete brain areas of mice .
9617783	0	phencyclidine	21,34	neuropeptide_Y	48,62	phencyclidine	neuropeptide Y	MESH:D010622	24604(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY treatment|nmod|END_ENTITY	The effects of acute phencyclidine treatment on neuropeptide_Y -LRB- NPY -RRB- neuronal system in the rat arcuate nucleus studied by immunocytochemistry and in situ hybridization .
7672001	0	phencyclidine	61,74	neurotensin	38,49	phencyclidine	neurotensin	MESH:D010622	4922	Chemical	Gene	Response|acl|START_ENTITY Response|nmod|systems systems|compound|END_ENTITY	Response of extrapyramidal and limbic neurotensin systems to phencyclidine treatment .
6634885	0	phencyclidine	66,79	prolactin	26,35	phencyclidine	prolactin	MESH:D010622	5617	Chemical	Gene	responses|nmod|START_ENTITY responses|compound|END_ENTITY	Cardiovascular and plasma prolactin responses to stereoisomers of phencyclidine .
10696810	0	phencyclidine	20,33	serotonin_transporter	47,68	phencyclidine	serotonin transporter	MESH:D010622	25553(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|END_ENTITY	Effects of repeated phencyclidine treatment on serotonin_transporter in rat brain .
6106663	0	phencyclidine	47,60	tyrosine_hydroxylase	64,84	phencyclidine	tyrosine hydroxylase	MESH:D010622	25085(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|amod|END_ENTITY	Effects of acute and chronic administration of phencyclidine on tyrosine_hydroxylase activity in rat striatum .
9459570	0	phenelzine	11,21	GAD67	114,119	phenelzine	GAD67	MESH:D010624	24379(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|dep|END_ENTITY	Effects of phenelzine and imipramine on the steady-state levels of mRNAs that encode glutamic_acid decarboxylase -LRB- GAD67 and GAD65 -RRB- , the GABA transporter GAT-1 and GABA_transaminase in rat cortex .
153184	0	phenelzine	29,39	MAO	14,17	phenelzine	MAO	MESH:D010624	29253(Tax:10116)	Chemical	Gene	inhibitor|dep|START_ENTITY inhibitor|nsubj|Effect Effect|nmod|END_ENTITY	-LSB- Effect of an MAO inhibitor , phenelzine , on acetylation of isoniazid by isolated perfused rat liver -RSB- .
8584653	0	phenelzine	29,39	MAO	15,18	phenelzine	MAO	MESH:D010624	29253(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|inhibitor inhibitor|compound|END_ENTITY	Effects of the MAO inhibitor phenelzine on glutamine and GABA concentrations in rat brain .
10736426	0	phenelzine	177,187	monoamine_oxidase	32,49	phenelzine	monoamine oxidase	MESH:D010624	29253(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|changes changes|nmod|activity activity|compound|END_ENTITY	Time-dependent changes in brain monoamine_oxidase activity and in brain levels of monoamines and amino_acids following acute administration of the antidepressant/antipanic drug phenelzine .
2597196	0	phenelzine	28,38	monoamine_oxidase	84,101	phenelzine	monoamine oxidase	MESH:D010624	29253(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Deuterium isotope effect of phenelzine on the inhibition of rat liver mitochondrial monoamine_oxidase activity .
7773544	0	phenelzine	15,25	monoamine_oxidase	36,53	phenelzine	monoamine oxidase	MESH:D010624	29253(Tax:10116)	Chemical	Gene	inhibitor|compound|START_ENTITY inhibitor|compound|END_ENTITY	The effects of phenelzine and other monoamine_oxidase inhibitor antidepressants on brain and liver I2 imidazoline-preferring receptors .
14567627	0	phenethyl_isothiocyanate	112,136	Nrf2	15,19	phenethyl isothiocyanate	Nrf2	MESH:C058305	4780	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of Nrf2 and JNK1 in the activation of antioxidant responsive element -LRB- ARE -RRB- by chemopreventive agent phenethyl_isothiocyanate -LRB- PEITC -RRB- .
23509350	0	phenethyl_isothiocyanate	24,48	TLR3	73,77	phenethyl isothiocyanate	TLR3	MESH:C058305	7098	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|signaling signaling|compound|END_ENTITY	Differential effects of phenethyl_isothiocyanate and D,L-sulforaphane on TLR3 signaling .
22607231	0	phenethyl_isothiocyanate	43,67	TSC2	97,101	phenethyl isothiocyanate	TSC2	MESH:C058305	7249	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	Natural product-derived antitumor compound phenethyl_isothiocyanate inhibits mTORC1 activity via TSC2 .
22607231	0	phenethyl_isothiocyanate	43,67	mTORC1	77,83	phenethyl isothiocyanate	mTORC1	MESH:C058305	382056(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Natural product-derived antitumor compound phenethyl_isothiocyanate inhibits mTORC1 activity via TSC2 .
16002050	0	phenethyl_isothiocyanate	21,45	multidrug_resistance_protein_2	61,91	phenethyl isothiocyanate	multidrug resistance protein 2	MESH:C058305	403632(Tax:9615)	Chemical	Gene	Transport|nmod|START_ENTITY mediated|nsubjpass|Transport mediated|nmod|END_ENTITY	Transport of dietary phenethyl_isothiocyanate is mediated by multidrug_resistance_protein_2 but not P-glycoprotein .
23682784	0	phenethyl_isothiocyanate	32,56	vimentin	70,78	phenethyl isothiocyanate	vimentin	MESH:C058305	7431	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|expression expression|compound|END_ENTITY	In vitro and in vivo effects of phenethyl_isothiocyanate treatment on vimentin protein expression in cancer cells .
11714275	0	phenethylamine	13,27	cytochrome_P450_2D6	43,62	phenethylamine	cytochrome P450 2D6	MESH:C029261	1565	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Oxidation of phenethylamine derivatives by cytochrome_P450_2D6 : the issue of substrate protonation in binding and catalysis .
20067583	0	phenethylamines	9,24	dopamine_transporter	34,54	phenethylamines	dopamine transporter	MESH:D010627	6531	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Bivalent phenethylamines as novel dopamine_transporter inhibitors : evidence for multiple substrate-binding sites in a single transporter .
19632840	0	phenethylpyridone	19,36	melanin-concentrating_hormone_1_receptor	59,99	phenethylpyridone	melanin-concentrating hormone 1 receptor	null	2847	Chemical	Gene	START_ENTITY|nmod|antagonists antagonists|amod|END_ENTITY	Discovery of novel phenethylpyridone derivatives as potent melanin-concentrating_hormone_1_receptor antagonists .
26807315	0	phenformin	64,74	KRAS	20,24	phenformin	KRAS	MESH:D010629	3845	Chemical	Gene	Targeting|nmod|START_ENTITY Targeting|dobj|END_ENTITY	Targeting oncogenic KRAS in non-small_cell_lung_cancer cells by phenformin inhibits growth and angiogenesis .
2165405	0	phenformin	111,121	delta-aminolevulinic_acid_synthase	24,58	phenformin	delta-aminolevulinic acid synthase	MESH:D010629	65155(Tax:10116)	Chemical	Gene	Studies|nmod|START_ENTITY Studies|nmod|END_ENTITY	Studies on induction of delta-aminolevulinic_acid_synthase , ferrochelatase , cytochrome_P-450 and cyclic_AMP by phenformin .
1149946	0	phenformin	14,24	insulin	47,54	phenformin	insulin	MESH:D010629	3630	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|compound|END_ENTITY	The effect of phenformin on amino_acid-induced insulin secretion in diabetics .
145295	0	phenformin	53,63	insulin	67,74	phenformin	insulin	MESH:D010629	483665(Tax:9615)	Chemical	Gene	doses|nmod|START_ENTITY effect|nmod|doses Lack|nmod|effect Lack|nmod|secretion secretion|compound|END_ENTITY	-LSB- Lack of concordance in the effect of large doses of phenformin on insulin secretion and glycemia .
4995366	0	phenformin	68,78	insulin	94,101	phenformin	insulin	MESH:D010629	3630	Chemical	Gene	demonstration|dep|START_ENTITY demonstration|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Experimental demonstration of the simulating action of biguanides -LRB- phenformin , metformin -RRB- on insulin secretion -RSB- .
7020721	0	phenformin	92,102	prolactin	7,16	phenformin	prolactin	MESH:D010629	5617	Chemical	Gene	-RSB-|compound|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- Serum prolactin in obese subjects with glucose_intolerance before and after treatment with phenformin -RSB- .
2445116	0	phenidone	41,50	5-lipoxygenase	16,30	phenidone	5-lipoxygenase	MESH:C015429	240	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|inhibitor inhibitor|amod|END_ENTITY	-LSB- Effects of the 5-lipoxygenase inhibitor phenidone on antigen-induced release of histamine in vitro -RSB- .
21481568	0	phenobarbital	40,53	CD1	114,117	phenobarbital	CD1	MESH:D010634	111334(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|mice mice|compound|END_ENTITY	Different effects of high - and low-dose phenobarbital on post-stroke seizure suppression and recovery in immature CD1 mice .
9448747	0	phenobarbital	10,23	CYP1A1	35,41	phenobarbital	CYP1A1	MESH:D010634	13076(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of phenobarbital on hepatic CYP1A1 and CYP1A2 in the Ahr-null mouse .
10064569	0	phenobarbital	23,36	CYP1A2	13,19	phenobarbital	CYP1A2	MESH:D010634	13077(Tax:10090)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of CYP1A2 by phenobarbital in the livers of aryl_hydrocarbon-responsive and - nonresponsive mice .
10205826	0	phenobarbital	123,136	CYP2B1	50,56	phenobarbital	CYP2B1	MESH:D010634	24300(Tax:10116)	Chemical	Gene	-RSB-|amod|START_ENTITY differences|nmod|-RSB- differences|nmod|END_ENTITY	-LSB- Interstrain differences in enzymatic activity of CYP2B1 and expression of its gene in the rat liver during induction with phenobarbital and triphenyldioxane -RSB- .
10529397	0	phenobarbital	110,123	CYP2B1	73,79	phenobarbital	CYP2B1	MESH:D010634	24300(Tax:10116)	Chemical	Gene	crucial|nmod|START_ENTITY crucial|nmod|induction induction|nmod|expression expression|compound|END_ENTITY	Phosphorylation/Dephosphorylation steps are crucial for the induction of CYP2B1 and CYP2B2 gene expression by phenobarbital .
9280408	0	phenobarbital	38,51	CYP2B1	73,79	phenobarbital	CYP2B1	MESH:D010634	24300(Tax:10116)	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Effect of ovariectomy and androgen on phenobarbital induction of hepatic CYP2B1 and CYP2B2 in Sprague-Dawley_rats .
10796078	0	phenobarbital	38,51	CYP2B2	31,37	phenobarbital	CYP2B2	MESH:D010634	361523(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|END_ENTITY	Positive regulation of the rat CYP2B2 phenobarbital response unit by the nuclear receptor hexamer half-site .
14569871	4	phenobarbital	845,858	CYP2C	823,828	phenobarbital	CYP3A	MESH:D010634	13112(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	CYP2B , CYP2C and CYP3A activities in the CP sensitive tumor were comparable to those in liver , and CYP2B , CYP2C were induced by phenobarbital and dexamethasone .
20166883	0	phenobarbital	29,42	Cytochrome_P450	0,15	phenobarbital	Cytochrome P450	MESH:D010634	25251(Tax:10116)	Chemical	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Cytochrome_P450 induction by phenobarbital exacerbates warm hepatic_ischemia-reperfusion_injury in rat livers .
3382400	0	phenobarbital	29,42	Cytochrome_P450	0,15	phenobarbital	Cytochrome P450	MESH:D010634	25251(Tax:10116)	Chemical	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Cytochrome_P450 induction by phenobarbital -LRB- PB -RRB- is inhibited by 12-O-tetradecanoylphorbol-13-acetate -LRB- TPA -RRB- : evidence that protein kinase C regulates induction .
9144458	0	phenobarbital	109,122	Cytochrome_P450	0,15	phenobarbital	Cytochrome P450	MESH:D010634	25251(Tax:10116)	Chemical	Gene	microsomes|amod|START_ENTITY trifluoroethane|nmod|microsomes inactivation|dep|trifluoroethane inactivation|amod|END_ENTITY	Cytochrome_P450 inactivation during reductive metabolism of 1,1-dichloro-2 ,2,2 - trifluoroethane -LRB- HCFC-123 -RRB- by phenobarbital - and pyridine-induced rat liver microsomes .
12231384	0	phenobarbital	44,57	P-glycoprotein	92,106	phenobarbital	P-glycoprotein	MESH:D010634	5243	Chemical	Gene	Lack|nmod|START_ENTITY Lack|nmod|END_ENTITY	Lack of effects of prolonged treatment with phenobarbital or phenytoin on the expression of P-glycoprotein in various rat brain regions .
18440557	0	phenobarbital	29,42	P-glycoprotein	75,89	phenobarbital	P-glycoprotein	MESH:D010634	287115(Tax:10116)	Chemical	Gene	exposure|nmod|START_ENTITY Effect|nmod|exposure Effect|nmod|expression expression|amod|END_ENTITY	Effect of 21-day exposure of phenobarbital , carbamazepine and phenytoin on P-glycoprotein expression and activity in the rat brain .
19708687	0	phenobarbital	43,56	PPARalpha	30,39	phenobarbital	PPARalpha	MESH:D010634	19013(Tax:10090)	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Transcriptional activation of PPARalpha by phenobarbital in the absence of CAR and PXR .
9029046	0	phenobarbital	67,80	UDP-glucuronosyltransferase	17,44	phenobarbital	UDP-glucuronosyltransferase	MESH:D010634	24862(Tax:10116)	Chemical	Gene	isoforms|amod|START_ENTITY isoforms|amod|END_ENTITY	Induction of two UDP-glucuronosyltransferase isoforms sensitive to phenobarbital that are involved in morphine glucuronidation : production of isoform-selective antipeptide antibodies toward UGT1 .1 r and UGT2B1 .
6409115	0	phenobarbital	19,32	UDP-glucuronyl_transferase	55,81	phenobarbital	UDP-glucuronyl transferase	MESH:D010634	574523(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	Effect of low-dose phenobarbital on hepatic microsomal UDP-glucuronyl_transferase activity .
1182203	0	phenobarbital	89,102	UDPglucose_dehydrogenase	13,37	phenobarbital	UDPglucose dehydrogenase	MESH:D010634	22235(Tax:10090)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of UDPglucose_dehydrogenase during development , organ culture , and exposure to phenobarbital .
2755909	0	phenobarbital	97,110	aldehyde_dehydrogenase	33,55	phenobarbital	aldehyde dehydrogenase	MESH:D010634	25375(Tax:10116)	Chemical	Gene	treatment|nmod|START_ENTITY END_ENTITY|nmod|treatment	Tissue distribution of inducible aldehyde_dehydrogenase activity in the rat after treatment with phenobarbital or methylcholanthrene .
8003099	0	phenobarbital	52,65	apolipoprotein_A-I	14,32	phenobarbital	apolipoprotein A-I	MESH:D010634	335	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of apolipoprotein_A-I gene expression by phenobarbital in the human hepatocarcinoma cell line , Hep3B .
10096431	0	phenobarbital	49,62	c-fos	0,5	phenobarbital	c-fos	MESH:D010634	314322(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|expression expression|amod|END_ENTITY	c-fos gene expression in rat liver is induced by phenobarbital .
10096431	6	phenobarbital	802,815	c-fos	855,860	phenobarbital	GST-P	MESH:D010634	24426(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	The results indicate that phenobarbital , a widely used tumor promoter , induces c-fos expression .
7060925	0	phenobarbital	23,36	choline_acetyltransferase	59,84	phenobarbital	choline acetyltransferase	MESH:D010634	290567(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activity activity|amod|END_ENTITY	Comparative effects of phenobarbital and picrotoxin on the choline_acetyltransferase activity of specific rat brain areas .
12124310	0	phenobarbital	90,103	constitutive_androstane_receptor	8,40	phenobarbital	constitutive androstane receptor	MESH:D010634	65035(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of constitutive_androstane_receptor in the in vivo induction of Mrp3 and CYP2B1/2 by phenobarbital .
24180433	0	phenobarbital	108,121	constitutive_androstane_receptor	133,165	phenobarbital	constitutive androstane receptor	MESH:D010634	9970	Chemical	Gene	activator|amod|START_ENTITY activator|compound|END_ENTITY	Mode of action and human relevance analysis for nuclear receptor-mediated liver_toxicity : A case study with phenobarbital as a model constitutive_androstane_receptor -LRB- CAR -RRB- activator .
3621980	0	phenobarbital	51,64	cytochrome_P-450	13,29	phenobarbital	cytochrome P-450	MESH:D010634	100328948(Tax:9986)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of cytochrome_P-450 in the rabbit eye by phenobarbital , as detected immunohistochemically .
4851681	0	phenobarbital	10,23	cytochrome_P-450	139,155	phenobarbital	cytochrome P-450	MESH:D010634	4051	Chemical	Gene	administration|amod|START_ENTITY Effect|nmod|administration Effect|nmod|END_ENTITY	Effect of phenobarbital and 3-methylcholanthrene administration in vivo and isooctane extraction in vitro on metyrapone binding to reduced cytochrome_P-450 .
15629132	0	phenobarbital	79,92	cytochrome_P-450_2B1	36,56	phenobarbital	cytochrome P-450 2B1	MESH:D010634	24300(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY expression|acl|induced expression|amod|END_ENTITY	Prostaglandin_E2 down-regulation of cytochrome_P-450_2B1 expression induced by phenobarbital is through EP2 receptor in rat hepatocytes .
12695350	0	phenobarbital	119,132	cytochrome_P450	35,50	phenobarbital	cytochrome P450	MESH:D010634	25251(Tax:10116)	Chemical	Gene	isoforms|nmod|START_ENTITY isoforms|nsubj|END_ENTITY	Constitutive and inducible hepatic cytochrome_P450 isoforms in senescent male and female rats and response to low-dose phenobarbital .
12739762	0	phenobarbital	55,68	cytochrome_P450	13,28	phenobarbital	cytochrome P450	MESH:D010634	4051	Chemical	Gene	expression|nmod|START_ENTITY expression|nsubj|Induction Induction|nmod|END_ENTITY	Induction of cytochrome_P450 2B6 and 3A4 expression by phenobarbital and cyclophosphamide in cultured human liver slices .
3965334	1	phenobarbital	131,144	cytochrome_P450	105,120	phenobarbital	cytochrome P450	MESH:D010634	25251(Tax:10116)	Chemical	Gene	caused|nmod|START_ENTITY caused|nsubj|characterization characterization|nmod|increase increase|nmod|END_ENTITY	Immunochemical characterization of the increase in cytochrome_P450 caused by phenobarbital .
7805614	0	phenobarbital	88,101	cytochrome_P450	25,40	phenobarbital	cytochrome P450	MESH:D010634	25251(Tax:10116)	Chemical	Gene	induction|amod|START_ENTITY rats|nmod|induction microsomes|nmod|rats END_ENTITY|nmod|microsomes	-LSB- A selective decrease in cytochrome_P450 in the liver microsomes of male rats following phenobarbital and 3-methylcholanthrene induction and acute tetrachloromethane poisoning -RSB- .
7906730	0	phenobarbital	113,126	cytochrome_P450	147,162	phenobarbital	cytochrome P450	MESH:D010634	25251(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|induction induction|nmod|END_ENTITY	Strychnine and brucine as the potent inducers of drug metabolizing enzymes in rat liver : different profiles from phenobarbital on the induction of cytochrome_P450 and UDP-glucuronosyltransferase .
8212741	0	phenobarbital	10,23	cytochrome_P450	52,67	phenobarbital	cytochrome P450	MESH:D010634	487648(Tax:9615)	Chemical	Gene	model|amod|START_ENTITY Effect|nmod|model inducers|nsubj|Effect inducers|nmod|isoenzymes isoenzymes|amod|END_ENTITY	Effect of phenobarbital and other model inducers on cytochrome_P450 isoenzymes in primary culture of dog hepatocytes .
8995791	0	phenobarbital	77,90	cytochrome_P450	44,59	phenobarbital	cytochrome P450	MESH:D010634	35587(Tax:7227)	Chemical	Gene	Inducibility|nmod|START_ENTITY Inducibility|nmod|gene gene|amod|END_ENTITY	Inducibility of the Drosophila_melanogaster cytochrome_P450 gene , CYP6A2 , by phenobarbital in insecticide susceptible or resistant strains .
971305	0	phenobarbital	58,71	cytochrome_P450	24,39	phenobarbital	cytochrome P450	MESH:D010634	25251(Tax:10116)	Chemical	Gene	hepatocytes|nmod|START_ENTITY END_ENTITY|nmod|hepatocytes	Site of biosynthesis of cytochrome_P450 in hepatocytes of phenobarbital treated rats .
9752718	0	phenobarbital	52,65	cytochrome_P450	14,29	phenobarbital	cytochrome P450	MESH:D010634	4051	Chemical	Gene	transcription|nmod|START_ENTITY transcription|nsubj|Regulation Regulation|nmod|gene gene|amod|END_ENTITY	Regulation of cytochrome_P450 gene transcription by phenobarbital .
6408085	0	phenobarbital	129,142	epoxide_hydratase	40,57	phenobarbital	epoxide hydratase	MESH:D010634	65030(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of rat liver epoxide_hydratase , NADPH-Cytochrome P-450 oxidoreductase , and cytochrome_P-450b genes by phenobarbital .
8609896	0	phenobarbital	144,157	ferrochelatase	240,254	phenobarbital	ferrochelatase	MESH:D010634	374020(Tax:9031)	Chemical	Gene	START_ENTITY|dep|inhibition inhibition|nmod|END_ENTITY	Isolation of N-vinylprotoporphyrin IX after hepatic cytochrome P450 inactivation by 3 - -LSB- -LRB- arylthio -RRB- ethyl -RSB- sydnone in chick embryos pretreated with phenobarbital , glutethimide , dexamethasone , and beta-naphthoflavone : differential inhibition of ferrochelatase by N-vinylprotoporphyrin regioisomers .
6674910	0	phenobarbital	10,23	glucose-6-phosphate_dehydrogenase	49,82	phenobarbital	glucose-6-phosphate dehydrogenase	MESH:D010634	2539	Chemical	Gene	treatment|amod|START_ENTITY Effect|nmod|treatment Effect|nmod|END_ENTITY	Effect of phenobarbital treatment on erythrocyte glucose-6-phosphate_dehydrogenase in human newborns .
2575507	0	phenobarbital	24,37	glutathione-S-transferase	49,74	phenobarbital	glutathione-S-transferase	MESH:D010634	58962(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activity activity|amod|END_ENTITY	Dose-related effects of phenobarbital on hepatic glutathione-S-transferase activity and ligandin levels in the rat .
2060617	0	phenobarbital	59,72	glutathione_S-transferase	14,39	phenobarbital	glutathione S-transferase	MESH:D010634	58962(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of glutathione_S-transferase gene expression by phenobarbital in cultured adult rat hepatocytes .
2315263	0	phenobarbital	131,144	glutathione_S-transferase	35,60	phenobarbital	glutathione S-transferase	MESH:D010634	58962(Tax:10116)	Chemical	Gene	rats|amod|START_ENTITY release|dobj|rats release|nsubj|relationship relationship|nmod|END_ENTITY	Inverse relationship between total glutathione_S-transferase content and bile_acid release in isolated hepatocytes from untreated , phenobarbital pretreated and hypothyroid rats .
2411220	0	phenobarbital	75,88	glutathione_S-transferase	40,65	phenobarbital	glutathione S-transferase	MESH:D010634	58962(Tax:10116)	Chemical	Gene	liver|advcl|START_ENTITY liver|dobj|genes genes|amod|END_ENTITY	Transcriptional regulation of rat liver glutathione_S-transferase genes by phenobarbital and 3-methylcholanthrene .
2635735	0	phenobarbital	42,55	glutathione_S-transferase	13,38	phenobarbital	glutathione S-transferase	MESH:D010634	58962(Tax:10116)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of glutathione_S-transferase by phenobarbital in rat hepatocyte culture .
2753164	0	phenobarbital	10,23	glutathione_S-transferase	45,70	phenobarbital	glutathione S-transferase	MESH:D010634	58962(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|isoenzymes isoenzymes|amod|END_ENTITY	Effect of phenobarbital on the expression of glutathione_S-transferase isoenzymes in cultured rat hepatocytes .
3105185	0	phenobarbital	29,42	glutathione_S-transferase	112,137	phenobarbital	glutathione S-transferase	MESH:D010634	58962(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY effects|nmod|treatment Difference|nmod|effects Difference|nmod|composition composition|nmod|END_ENTITY	Difference in the effects of phenobarbital and 3-methylcholanthrene treatment on subunit composition of hepatic glutathione_S-transferase in male and female rats .
6546728	0	phenobarbital	49,62	glutathione_S-transferase	14,39	phenobarbital	glutathione S-transferase	MESH:D010634	373156	Chemical	Gene	mRNAs|acl|START_ENTITY mRNAs|amod|END_ENTITY	Regulation of glutathione_S-transferase mRNAs by phenobarbital and 3-methylcholanthrene : analysis using cDNA probes .
7317837	0	phenobarbital	10,23	growth_hormone	54,68	phenobarbital	growth hormone	MESH:D010634	2688	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of phenobarbital on sleep and nighttime plasma growth_hormone and cortisol levels .
3802391	0	phenobarbital	142,155	ornithine_decarboxylase	95,118	phenobarbital	ornithine decarboxylase	MESH:D010634	24609(Tax:10116)	Chemical	Gene	promoters|amod|START_ENTITY END_ENTITY|nmod|promoters	Inhibition by indomethacin and 5,8,11,14-eicosatetraynoic _ acid of the induction of rat hepatic ornithine_decarboxylase by the tumor promoters phenobarbital and 12-O-tetradecanoylphorbol-13-acetate in vivo .
7273008	0	phenobarbital	13,26	ornithine_decarboxylase	30,53	phenobarbital	ornithine decarboxylase	MESH:D010634	24609(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Induction by phenobarbital of ornithine_decarboxylase activity in rat liver after initiation with diethylnitrosamine .
9698295	0	phenobarbital	67,80	sulfotransferase	38,54	phenobarbital	sulfotransferase	MESH:D010634	140568(Tax:10116)	Chemical	Gene	isoforms|nmod|START_ENTITY isoforms|nsubj|regulation regulation|nmod|END_ENTITY	Differential regulation of individual sulfotransferase isoforms by phenobarbital in male rat liver .
38935	0	phenobarbitone	10,24	apolipoprotein_B	35,51	phenobarbitone	apolipoprotein B	MESH:D010634	338	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of phenobarbitone on plasma apolipoprotein_B and plasma high-density-lipoprotein cholesterol in normal subjects .
6614916	0	phenobarbitone	103,117	cytochrome_P-450	73,89	phenobarbitone	cytochrome P-450	MESH:D010634	25251(Tax:10116)	Chemical	Gene	synthesis|nmod|START_ENTITY synthesis|amod|END_ENTITY	Effect of cobalt_chloride and 3-amino-1 ,2,4 - triazole on the induction of cytochrome_P-450 synthesis by phenobarbitone in rat liver .
23923552	0	phenobarbitone	10,24	cytochrome_P450	28,43	phenobarbitone	cytochrome P450	MESH:D010634	25251(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effect of phenobarbitone on cytochrome_P450 activity and chlorpyrifos and 3,5,6-trichloropyridinol levels in liver and serum in rat .
16966304	0	phenol	120,126	Carcinoembryonic_antigen	0,24	phenol	Carcinoembryonic antigen	MESH:D019800	1084	Chemical	Gene	exposed|nmod|START_ENTITY exposed|nsubj|END_ENTITY	Carcinoembryonic_antigen , alpha-fetoprotein , and prostate-specific_antigen in the sera of industrial workers exposed to phenol , formaldehyde , urea , and mixed vapors .
11355194	0	phenol	22,28	NO3	34,37	phenol	NO3	MESH:D019800	4681	Chemical	Gene	reaction|nmod|START_ENTITY reaction|nmod|END_ENTITY	Gas-phase reaction of phenol with NO3 .
7802665	0	phenol	75,81	STM	105,108	phenol	STM	MESH:D019800	6818	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic organization and DNA sequence of the human catecholamine-sulfating phenol sulfotransferase gene -LRB- STM -RRB- .
7860079	0	phenol	77,83	STP	102,105	phenol	STP	MESH:D019800	6817	Chemical	Gene	sulfotransferase|amod|START_ENTITY sulfotransferase|appos|END_ENTITY	Detection of a HindIII restriction fragment length polymorphism in the human phenol sulfotransferase -LRB- STP -RRB- locus .
7999068	0	phenol	15,21	STP	47,50	phenol	STP	MESH:D019800	6817	Chemical	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Mapping of two phenol sulphotransferase genes , STP and STM , to 16p : candidate genes for Batten_disease .
8288252	0	phenol	15,21	STP	45,48	phenol	STP	MESH:D019800	6817	Chemical	Gene	gene|amod|START_ENTITY Mapping|nmod|gene Mapping|appos|END_ENTITY	Mapping of the phenol sulfotransferase gene -LRB- STP -RRB- to human chromosome 16p12.1-p11 .2 and to mouse chromosome 7 .
9119390	0	phenol	71,77	STP2	95,99	phenol	STP2	MESH:D019800	6799	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Cloning , structural organization , and chromosomal mapping of the human phenol sulfotransferase STP2 gene .
10548061	0	phenol	69,75	SULT1A1	94,101	phenol	SULT1A1	MESH:D019800	6817	Chemical	Gene	sulfotransferase|amod|START_ENTITY sulfotransferase|appos|END_ENTITY	Photoaffinity labeling probe for the substrate binding site of human phenol sulfotransferase -LRB- SULT1A1 -RRB- : 7-azido-4-methylcoumarin .
11123927	0	phenol	46,52	SULT1A1	71,78	phenol	SULT1A1	MESH:D019800	6817	Chemical	Gene	sulfotransferase|amod|START_ENTITY sulfotransferase|appos|END_ENTITY	Carboxyl residues in the active site of human phenol sulfotransferase -LRB- SULT1A1 -RRB- .
11191883	0	phenol	16,22	SULT1A1	50,57	phenol	SULT1A1	MESH:D019800	6817	Chemical	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Relationship of phenol sulfotransferase activity -LRB- SULT1A1 -RRB- genotype to sulfotransferase phenotype in platelet cytosol .
12065059	0	phenol	14,20	SULT1A1	39,46	phenol	SULT1A1	MESH:D019800	6817	Chemical	Gene	sulfotransferase|amod|START_ENTITY Inhibition|nmod|sulfotransferase Inhibition|appos|END_ENTITY	Inhibition of phenol sulfotransferase -LRB- SULT1A1 -RRB- by quercetin in human adult and foetal livers .
12745871	0	phenol	34,40	SULT1A1	59,66	phenol	SULT1A1	MESH:D019800	6817	Chemical	Gene	sulfotransferase|amod|START_ENTITY sulfotransferase|appos|END_ENTITY	Curcumin is a potent inhibitor of phenol sulfotransferase -LRB- SULT1A1 -RRB- in human liver and extrahepatic tissues .
12867416	0	phenol	46,52	SULT1A1	71,78	phenol	SULT1A1	MESH:D019800	6817	Chemical	Gene	sulfotransferase|amod|START_ENTITY sulfotransferase|appos|END_ENTITY	Arginine residues in the active site of human phenol sulfotransferase -LRB- SULT1A1 -RRB- .
14660177	0	phenol	98,104	SULT1A1	123,130	phenol	SULT1A1	MESH:D019800	6817	Chemical	Gene	sulfotransferase|amod|START_ENTITY sulfotransferase|appos|END_ENTITY	Sulfation of apomorphine by human sulfotransferases : evidence of a major role for the polymorphic phenol sulfotransferase , SULT1A1 .
18368507	0	phenol	41,47	SULT1A1	65,72	phenol	SULT1A1	MESH:D019800	6817	Chemical	Gene	polymorphism|amod|START_ENTITY polymorphism|compound|END_ENTITY	Further evidence for null association of phenol sulfotransferase SULT1A1 polymorphism with prostate_cancer risk : a case-control study of familial_prostate_cancer in a Japanese population .
25720860	0	phenol	21,27	SULT1A1	46,53	phenol	SULT1A1	MESH:D019800	83783(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|sulfotransferase sulfotransferase|appos|END_ENTITY	Ethanol up-regulates phenol sulfotransferase -LRB- SULT1A1 -RRB- and hydroxysteroid_sulfotransferase -LRB- SULT2A1 -RRB- in rat liver and intestine .
20566371	0	phenol	51,57	SULT1A3	76,83	phenol	SULT1A3	MESH:D019800	6818	Chemical	Gene	sulfotransferase|amod|START_ENTITY sulfotransferase|appos|END_ENTITY	Spectrofluorometric assay for monoamine-preferring phenol sulfotransferase -LRB- SULT1A3 -RRB- .
16475821	0	phenol	49,55	UDP-glucuronosyltransferase_1A10	78,110	phenol	UDP-glucuronosyltransferase 1A10	MESH:D019800	54575	Chemical	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Phenylalanine 90 and 93 are localized within the phenol binding site of human UDP-glucuronosyltransferase_1A10 as determined by photoaffinity labeling , mass spectrometry , and site-directed mutagenesis .
24411447	0	phenol	43,49	peroxidase	19,29	phenol	peroxidase	MESH:D019800	547504(Tax:3847)	Chemical	Gene	treatment|nmod|START_ENTITY treatment|compound|END_ENTITY	Crude soybean hull peroxidase treatment of phenol in synthetic and real wastewater : enzyme economy enhanced by Triton_X-100 .
16621480	0	phenol	26,32	sulfotransferase_1A1	33,53	phenol	sulfotransferase 1A1	MESH:D019800	6817	Chemical	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Frequency distribution of phenol sulfotransferase_1A1 activity in platelet cells from healthy Japanese subjects .
20054468	0	phenol	70,76	tyrosinase	88,98	phenol	tyrosinase	MESH:D019800	7299	Chemical	Gene	removal|amod|START_ENTITY removal|nmod|END_ENTITY	Enzymatic reactions in near critical CO : The effect of pressure on phenol removal by tyrosinase .
18155342	0	phenolic_acids	30,44	glutathione_S-transferase	66,91	phenolic acids	glutathione S-transferase	null	58962(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|isozymes isozymes|amod|END_ENTITY	Effect of naturally occurring phenolic_acids on the expression of glutathione_S-transferase isozymes in the rat .
15857113	0	phenolic_acyl_hydrazones	54,78	estrogen-related_orphan_nuclear_receptors_ERRbeta_and_ERRgamma	109,171	phenolic acyl hydrazones	estrogen-related orphan nuclear receptors ERRbeta and ERRgamma	null	2104	Chemical	Gene	relationship|nmod|START_ENTITY relationship|nmod|END_ENTITY	Identification and structure-activity relationship of phenolic_acyl_hydrazones as selective agonists for the estrogen-related_orphan_nuclear_receptors_ERRbeta_and_ERRgamma .
10418336	0	phenolic_fatty_acid_ester	6,31	lipoxygenase	37,49	phenolic fatty acid ester	lipoxygenase	null	547836(Tax:3847)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	A new phenolic_fatty_acid_ester with lipoxygenase inhibitory activity from Jacaranda filicifolia .
15043408	0	phenolic_glycosides	10,29	virH	59,63	phenolic glycosides	virH	null	6382028(Tax:358)	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of phenolic_glycosides on Agrobacterium_tumefaciens virH gene induction and plant transformation .
8157532	0	phenolic_monoamines	11,30	gonadotropin-releasing_hormone	79,109	phenolic monoamines	gonadotropin-releasing hormone	null	2796	Chemical	Gene	Effects|nmod|START_ENTITY stimulated|nsubj|Effects stimulated|nmod|END_ENTITY	Effects of phenolic_monoamines on release of luteinizing hormone stimulated by gonadotropin-releasing_hormone and on plasma adrenocorticotropic_hormone , norepinephrine , and cortisol concentrations in wethers .
15120715	0	phenolics	6,15	5-lipoxygenase	35,49	phenolics	5-lipoxygenase	null	240	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|END_ENTITY	Spice phenolics inhibit human PMNL 5-lipoxygenase .
17388968	0	phenolics	15,24	C-reactive_protein	45,63	phenolics	C-reactive protein	null	1401	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effect of wine phenolics on cytokine-induced C-reactive_protein expression .
17703733	0	phenolics	6,15	prolyl_endopeptidase	19,39	phenolics	prolyl endopeptidase	null	5550	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Plant phenolics as prolyl_endopeptidase inhibitors .
18613133	0	phenols	11,18	tyrosinase	62,72	phenols	tyrosinase	MESH:D010636	7299	Chemical	Gene	Removal|nmod|START_ENTITY Removal|nmod|END_ENTITY	Removal of phenols from wastewater by soluble and immobilized tyrosinase .
6947252	0	phenothiazine	87,100	S100b	33,38	phenothiazine	S100b	MESH:C031637	525716(Tax:9913)	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Calcium-dependent interaction of S100b , troponin_C , and calmodulin with an immobilized phenothiazine .
8155702	0	phenothiazine	39,52	methemoglobin	68,81	phenothiazine	methemoglobin	MESH:C031637	3048	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Kinetic evaluation of the oxidation of phenothiazine derivatives by methemoglobin and horseradish peroxidase in the presence of hydrogen_peroxide .
12259440	0	phenothiazine	30,43	prolactin	55,64	phenothiazine	prolactin	MESH:C031637	5617	Chemical	Gene	START_ENTITY|dobj|secretion secretion|compound|END_ENTITY	Endogenous estrogen modulates phenothiazine stimulated prolactin secretion .
2298188	0	phenothiazine	14,27	prolactin	38,47	phenothiazine	prolactin	MESH:C031637	100034034(Tax:9796)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|levels levels|compound|END_ENTITY	The effect of phenothiazine on plasma prolactin levels in non-pregnant mares .
977726	0	phenothiazine	30,43	prolactin	55,64	phenothiazine	prolactin	MESH:C031637	5617	Chemical	Gene	START_ENTITY|dobj|secretion secretion|compound|END_ENTITY	Endogenous estrogen modulates phenothiazine stimulated prolactin secretion .
20023237	0	phenothiazines	23,37	MRP1	41,45	phenothiazines	MRP1	MESH:D010640	4363	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Differential effect of phenothiazines on MRP1 and P-glycoprotein activity .
4988494	0	phenothiazines	10,24	tyrosinase	37,47	phenothiazines	tyrosinase	MESH:D010640	7299	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of phenothiazines on melanoma tyrosinase activity .
6257528	0	phenoxybenzamine	15,31	VIP	10,13	phenoxybenzamine	VIP	MESH:D010643	100735454	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of VIP , phenoxybenzamine and prednisolone on cyclic_nucleotide content of isolated guinea-pig lung and trachea .
6266906	0	phenoxybenzamine	14,30	gastrin	38,45	phenoxybenzamine	gastrin	MESH:D010643	100685087	Chemical	Gene	START_ENTITY|nmod|response response|compound|END_ENTITY	The effect of phenoxybenzamine on the gastrin response to glycine stimulation .
11023648	0	phenoxyherbicides	51,68	Catalase	0,8	phenoxyherbicides	Catalase	CHEBI:60575	847	Chemical	Gene	effect|nmod|START_ENTITY activity|dep|effect activity|amod|END_ENTITY	Catalase activity in human erythrocytes : effect of phenoxyherbicides and their metabolites .
10845768	0	phentolamine	5,17	alpha-1	22,29	phentolamine	alpha-1	MESH:D010646	146	Chemical	Gene	START_ENTITY|dep|antagonist antagonist|amod|END_ENTITY	Oral phentolamine : an alpha-1 , alpha-2 adrenergic antagonist for the treatment of erectile_dysfunction .
10849569	0	phentolamine	5,17	alpha-1	22,29	phentolamine	alpha-1	MESH:D010646	146	Chemical	Gene	START_ENTITY|dep|antagonist antagonist|amod|END_ENTITY	Oral phentolamine : an alpha-1 , alpha-2 adrenergic antagonist for the treatment of erectile_dysfunction .
7244331	0	phentolamine	11,23	growth_hormone	80,94	phentolamine	growth hormone	MESH:D010646	2688	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	-LSB- Effect of phentolamine , diphenhydramine and cyproheptadine on arginine-induced growth_hormone secretion -LRB- author 's transl -RRB- -RSB- .
7433752	0	phentolamine	19,31	growth_hormone	72,86	phentolamine	growth hormone	MESH:D010646	2688	Chemical	Gene	Lack|nmod|START_ENTITY Lack|nmod|secretion secretion|amod|END_ENTITY	-LSB- Lack of action of phentolamine , fenfluramine and cyproheptadine on the growth_hormone secretion induced by glucagon -LRB- author 's transl -RRB- -RSB- .
402275	0	phentolamine	17,29	insulin	64,71	phentolamine	insulin	MESH:D010646	3630	Chemical	Gene	influence|nmod|START_ENTITY influence|nmod|secretion secretion|compound|END_ENTITY	The influence of phentolamine , an adrenergic blocking agent , on insulin secretion during surgery .
7178369	0	phentolamine	21,33	prolactin	113,122	phentolamine	prolactin	MESH:D010646	5617	Chemical	Gene	secretion|amod|START_ENTITY effect|nmod|secretion effect|nmod|END_ENTITY	Inhibitory effect of phentolamine on diazepam-induced growth_hormone secretion and lack of effect of diazepam on prolactin secretion in man .
12190324	0	phenyl	180,186	dopamine_transporter	209,229	phenyl	dopamine transporter	CHEBI:30396	6531	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Synthesis and transporter binding properties of 3beta - -LSB- 4 ' - -LRB- phenylalkyl , _ - phenylalkenyl , _ and _ - phenylalkynyl -RRB- phenyl -RSB- tropane-2beta-carboxylic_acid_methyl_esters : evidence of a remote phenyl binding domain on the dopamine_transporter .
6195457	0	phenyl-2-aminoethyl_sulfide	11,38	dopamine-beta-hydroxylase	48,73	phenyl-2-aminoethyl sulfide	dopamine-beta-hydroxylase	MESH:C039557	448806(Tax:9615)	Chemical	Gene	START_ENTITY|appos|substrate substrate|amod|END_ENTITY	Effects of phenyl-2-aminoethyl_sulfide , a novel dopamine-beta-hydroxylase substrate , on the cardiovascular system of the anesthetized dog .
8512561	0	phenyl-sepharose	81,97	calreticulin	12,24	phenyl-sepharose	calreticulin	MESH:C020927	811	Chemical	Gene	interaction|nmod|START_ENTITY END_ENTITY|dep|interaction	Human liver calreticulin : characterization and Zn -LRB- 2 + -RRB- - dependent interaction with phenyl-sepharose .
4031869	0	phenyl_azides	35,48	monoamine_oxidase	14,31	phenyl azides	monoamine oxidase	null	29253(Tax:10116)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of monoamine_oxidase by phenyl_azides .
20160952	0	phenyl_cyanate	72,86	OCN	58,61	phenyl cyanate	OCN	CHEBI:38903	632	Chemical	Gene	region|nmod|START_ENTITY region|compound|END_ENTITY	2D IR photon echo study of the anharmonic coupling in the OCN region of phenyl_cyanate .
2344468	0	phenyl_iron	64,75	myoglobin	87,96	phenyl iron	myoglobin	null	100054434(Tax:9796)	Chemical	Gene	complex|compound|START_ENTITY complex|nmod|END_ENTITY	Resonance Raman enhancement of phenyl ring vibrational modes in phenyl_iron complex of myoglobin .
15916445	0	phenyl_ketone	60,73	cyclooxygenase-2	104,120	phenyl ketone	cyclooxygenase-2	null	5743	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|amod|END_ENTITY	3 - -LSB- 4 - -LRB- methylsulfonyl -RRB- phenyl -RSB- -5 - -LRB- trifluoromethyl -RRB- -LRB- 2-pyridyl -RRB- phenyl_ketone as a potent and orally active cyclooxygenase-2 selective inhibitor : synthesis and biological evaluation .
12076317	0	phenyl_selenoacetylene	48,70	Delta-aminolevulinate_dehydratase	0,33	phenyl selenoacetylene	Delta-aminolevulinate dehydratase	MESH:C469411	210	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Delta-aminolevulinate_dehydratase inhibition by phenyl_selenoacetylene : effect of reaction with hydrogen_peroxide .
15389747	0	phenyl_triazolinones	50,70	protoporphyrinogen_oxidase	74,100	phenyl triazolinones	protoporphyrinogen oxidase	null	5498	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Quantitative structure-activity relationships for phenyl_triazolinones of protoporphyrinogen_oxidase inhibitors : a density functional theory study .
8827086	0	phenylacetate	26,39	prostate-specific_antigen	50,75	phenylacetate	prostate-specific antigen	MESH:C025136|MESH:C570634	354	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|production production|amod|END_ENTITY	The differentiating agent phenylacetate increases prostate-specific_antigen production by prostate_cancer cells .
22119474	0	phenylacetic_acid	16,33	CRTH2	50,55	phenylacetic acid	CRTH2	MESH:C025136	11251	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Optimization of phenylacetic_acid derivatives for CRTH2 and DP selective antagonism .
12865413	0	phenylacetic_acid	17,34	iNOS	85,89	phenylacetic acid	iNOS	MESH:C025136	51477	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Increased plasma phenylacetic_acid in patients with end-stage_renal_failure inhibits iNOS expression .
2330597	0	phenylalanine	6,19	CCl4	78,82	phenylalanine	CCl4	CHEBI:28044	116637(Tax:10116)	Chemical	Gene	induced|nsubj|START_ENTITY induced|nmod|END_ENTITY	Brain phenylalanine and tyrosine levels and hepatic_encephalopathy induced by CCl4 in rats .
22973849	7	phenylalanine	975,988	EFhd2	992,997	phenylalanine	EFhd2	CHEBI:28044	79180	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Furthermore , characterization of an identified single-nucleotide polymorphisms -LRB- SNP -RRB- that introduced a missense mutation indicates the importance of a conserved phenylalanine on EFhd2 calcium binding activity .
10702592	0	phenylalanine	19,32	Insulin	0,7	phenylalanine	Insulin	CHEBI:28044	105613195	Chemical	Gene	uptake|compound|START_ENTITY stimulates|dobj|uptake stimulates|nsubj|END_ENTITY	Insulin stimulates phenylalanine uptake across the hind limb in fed lambs .
18433550	0	phenylalanine	11,24	Nogo-66_receptor	32,48	phenylalanine	Nogo-66 receptor	CHEBI:28044	113912(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	-LSB- Effect of phenylalanine on the Nogo-66_receptor expression in the cortical neurons of rats -RSB- .
24642849	0	phenylalanine	32,45	PAL1	66,70	phenylalanine	PAL1	CHEBI:28044	818280(Tax:3702)	Chemical	Gene	START_ENTITY|dobj|gene gene|appos|END_ENTITY	An important role of the pepper phenylalanine ammonia-lyase gene -LRB- PAL1 -RRB- in salicylic_acid-dependent signalling of the defence response to microbial pathogens .
1588831	0	phenylalanine	23,36	Prolactin	0,9	phenylalanine	Prolactin	CHEBI:28044	5617	Chemical	Gene	responses|nmod|START_ENTITY responses|compound|END_ENTITY	Prolactin responses to phenylalanine and tyrosine in phenylketonuria .
17515837	0	phenylalanine	24,37	Rac1	41,45	phenylalanine	Rac1	CHEBI:28044	5879	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Differential effects of phenylalanine on Rac1 , Cdc42 , and RhoA expression and activity in cultured cortical neurons .
16782051	0	phenylalanine	42,55	Stat1	14,19	phenylalanine	Stat1	CHEBI:28044	6772	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of Stat1 protein expression by phenylalanine 172 in the coiled-coil domain .
12132693	0	phenylalanine	42,55	acetylcholinesterase	59,79	phenylalanine	acetylcholinesterase	CHEBI:28044	43	Chemical	Gene	effect|nmod|START_ENTITY reverses|dobj|effect reverses|nmod|activity activity|amod|END_ENTITY	Alanine reverses the inhibitory effect of phenylalanine on acetylcholinesterase activity .
9618943	0	phenylalanine	22,35	acetylcholinesterase	39,59	phenylalanine	acetylcholinesterase	CHEBI:28044	43	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	In vitro influence of phenylalanine on acetylcholinesterase activity and DNA .
20101519	0	phenylalanine	11,24	brain-derived_neurotrophic_factor	132,165	phenylalanine	brain-derived neurotrophic factor	CHEBI:28044	24225(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|dep|involvement involvement|nmod|END_ENTITY	Effects of phenylalanine on the survival and neurite outgrowth of rat cortical neurons in primary cultures : possible involvement of brain-derived_neurotrophic_factor .
9756868	0	phenylalanine	14,27	calmodulin	46,56	phenylalanine	calmodulin	CHEBI:28044	852406(Tax:4932)	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	Importance of phenylalanine residues of yeast calmodulin for target binding and activation .
7517671	0	phenylalanine	107,120	cholecystokinin	14,29	phenylalanine	cholecystokinin	CHEBI:28044	885	Chemical	Gene	effects|nmod|START_ENTITY Regulation|dep|effects Regulation|nmod|secretion secretion|compound|END_ENTITY	Regulation of cholecystokinin secretion by calcium-dependent calmodulin kinase II : differential effects of phenylalanine and cAMP .
2713326	0	phenylalanine	60,73	dihydrofolate_reductase	99,122	phenylalanine	dihydrofolate reductase	CHEBI:28044	1719	Chemical	Gene	START_ENTITY|nmod|function function|nmod|END_ENTITY	Effects of conversion of an invariant tryptophan residue to phenylalanine on the function of human dihydrofolate_reductase .
7615519	0	phenylalanine	18,31	growth_hormone_receptor	47,70	phenylalanine	growth hormone receptor	CHEBI:28044	25235(Tax:10116)	Chemical	Gene	Identification|nmod|START_ENTITY END_ENTITY|nsubj|Identification	Identification of phenylalanine 346 in the rat growth_hormone_receptor as being critical for ligand-mediated internalization and down-regulation .
16941278	0	phenylalanine	30,43	insulin	72,79	phenylalanine	insulin	CHEBI:28044	3630	Chemical	Gene	administered|dobj|START_ENTITY administered|nmod|concentrations concentrations|compound|END_ENTITY	Effect of orally administered phenylalanine with and without glucose on insulin , glucagon and glucose concentrations .
23984046	0	phenylalanine	23,36	insulin	87,94	phenylalanine	insulin	CHEBI:28044	3630	Chemical	Gene	Ingestion|nmod|START_ENTITY produces|nsubj|Ingestion produces|nmod|END_ENTITY	Ingestion of leucine + phenylalanine with glucose produces an additive effect on serum insulin but less than additive effect on plasma glucose .
2649499	0	phenylalanine	12,25	insulin	54,61	phenylalanine	insulin	CHEBI:28044	3630	Chemical	Gene	side|compound|START_ENTITY Role|nmod|side chain|nsubj|Role chain|advcl|directing directing|dobj|interaction interaction|compound|END_ENTITY	Role of the phenylalanine B24 side chain in directing insulin interaction with its receptor .
3036097	0	phenylalanine	71,84	insulin	12,19	phenylalanine	insulin	CHEBI:28044	3630	Chemical	Gene	hydroxylation|compound|START_ENTITY role|nmod|hydroxylation role|nmod|END_ENTITY	The role of insulin in the modulation of glucagon-dependent control of phenylalanine hydroxylation in isolated liver cells .
497291	0	phenylalanine	49,62	insulin	29,36	phenylalanine	insulin	CHEBI:28044	3630	Chemical	Gene	modified|nmod|START_ENTITY modified|nsubj|Synthesis Synthesis|nmod|END_ENTITY	-LSB- Synthesis and properties of insulin modified on phenylalanine of chain B -RSB- .
8097152	0	phenylalanine	56,69	insulin	11,18	phenylalanine	insulin	CHEBI:28044	396145(Tax:9031)	Chemical	Gene	extraction|compound|START_ENTITY Effects|nmod|extraction Effects|nmod|END_ENTITY	Effects of insulin , growth_hormone , IGF-I and IGF-II on phenylalanine extraction in the chicken embryo cultured in vitro .
8916274	0	phenylalanine	15,28	insulin	63,70	phenylalanine	insulin	CHEBI:28044	3630	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|receptor receptor|amod|binding binding|nmod|I I|compound|END_ENTITY	Involvement of phenylalanine 23 in the binding of IGF-1 to the insulin and type I IGF receptor .
12670959	0	phenylalanine	75,88	myristoylated_alanine-rich_C_kinase_substrate	96,141	phenylalanine	myristoylated alanine-rich C kinase substrate	CHEBI:28044	4082	Chemical	Gene	START_ENTITY|nmod|domain domain|amod|END_ENTITY	Binding of peptides with basic and aromatic residues to bilayer membranes : phenylalanine in the myristoylated_alanine-rich_C_kinase_substrate effector domain penetrates into the hydrophobic core of the bilayer .
8425536	0	phenylalanine	27,40	phenylalanine_4-monooxygenase	44,73	phenylalanine	phenylalanine 4-monooxygenase	CHEBI:28044	5053	Chemical	Gene	cooperative|nmod|START_ENTITY cooperative|nmod|END_ENTITY	The cooperative binding of phenylalanine to phenylalanine_4-monooxygenase studied by 1H-NMR paramagnetic relaxation .
10964764	0	phenylalanine	92,105	phenylalanine_hydroxylase	46,71	phenylalanine	phenylalanine hydroxylase	CHEBI:28044	5053	Chemical	Gene	Studies|nmod|START_ENTITY Studies|nmod|END_ENTITY	Studies of ochratoxin_A-induced inhibition of phenylalanine_hydroxylase and its reversal by phenylalanine .
11175307	0	phenylalanine	47,60	phenylalanine_hydroxylase	82,107	phenylalanine	phenylalanine hydroxylase	CHEBI:28044	5053	Chemical	Gene	START_ENTITY|nmod|overexpression overexpression|nmod|END_ENTITY	Development of a skin-based metabolic sink for phenylalanine by overexpression of phenylalanine_hydroxylase and GTP cyclohydrolase in primary human keratinocytes .
6981644	0	phenylalanine	52,65	phenylalanine_hydroxylase	14,39	phenylalanine	phenylalanine hydroxylase	CHEBI:28044	24616(Tax:10116)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|activity activity|amod|END_ENTITY	Regulation of phenylalanine_hydroxylase activity by phenylalanine in vivo , in vitro , and in perfused rat liver .
9012811	0	phenylalanine	12,25	phenylalanine_hydroxylase	65,90	phenylalanine	phenylalanine hydroxylase	CHEBI:28044	24616(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|relationships relationships|nmod|END_ENTITY	The role of phenylalanine in structure-function relationships of phenylalanine_hydroxylase revealed by radiation target analysis .
2307734	0	phenylalanine	40,53	prolactin	72,81	phenylalanine	prolactin	CHEBI:28044	5617	Chemical	Gene	START_ENTITY|nmod|stimulation stimulation|nmod|secretion secretion|compound|END_ENTITY	Evidence for an intracerebral action of phenylalanine in stimulation of prolactin secretion : interaction of large neutral amino_acids .
7961902	0	phenylalkylamine	64,80	Ca2	81,84	phenylalkylamine	Ca2	CHEBI:60977	100719293	Chemical	Gene	START_ENTITY|dobj|protein protein|amod|END_ENTITY	Purification and amino-terminal sequencing of the high affinity phenylalkylamine Ca2 + antagonist binding protein from guinea_pig liver endoplasmic reticulum .
24352565	0	phenylarsine_oxide	95,113	CalDAG-GEFI	18,29	phenylarsine oxide	CalDAG-GEFI	MESH:C029341	10235	Chemical	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification of CalDAG-GEFI as an intracellular target for the vicinal_dithiol binding agent phenylarsine_oxide in human platelets .
19686715	0	phenylarsine_oxide	15,33	GLUT1	71,76	phenylarsine oxide	GLUT1	MESH:C029341	20525(Tax:10090)	Chemical	Gene	action|nmod|START_ENTITY action|nmod|END_ENTITY	Dual action of phenylarsine_oxide on the glucose transport activity of GLUT1 .
10754306	0	phenylarsine_oxide	46,64	L-selectin	97,107	phenylarsine oxide	L-selectin	MESH:C029341	6402	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|END_ENTITY	Sulfhydryl regulation of L-selectin shedding : phenylarsine_oxide promotes activation-independent L-selectin shedding from leukocytes .
11768235	0	phenylarsine_oxide	33,51	heme_oxygenase-1	13,29	phenylarsine oxide	heme oxygenase-1	MESH:C029341	3162	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of heme_oxygenase-1 by phenylarsine_oxide .
8581968	0	phenylarsine_oxide	54,72	protein_tyrosine_phosphatase	15,43	phenylarsine oxide	protein tyrosine phosphatase	MESH:C029341	26191	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Effects of the protein_tyrosine_phosphatase inhibitor phenylarsine_oxide on excision-activated calcium channels in Lymnaea neurons .
24750613	0	phenylboronic_acid	62,80	insulin	106,113	phenylboronic acid	insulin	MESH:C010686	3630	Chemical	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	pH - and glucose-sensitive glycopolymer nanoparticles based on phenylboronic_acid for triggered release of insulin .
15939622	0	phenylbutazone	45,59	COX-1	0,5	phenylbutazone	COX-1	MESH:D010653	807850(Tax:9796)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|END_ENTITY	COX-1 and COX-2 inhibition in horse blood by phenylbutazone , flunixin , carprofen and meloxicam : an in vitro analysis .
16930300	0	phenylbutazone	49,63	alpha1-antiproteinase	16,37	phenylbutazone	alpha1-antiproteinase	MESH:D010653	5265	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Inactivation of alpha1-antiproteinase induced by phenylbutazone : participation of peroxyl radicals and hydroperoxide .
19375914	0	phenylcarboxyamides	45,64	BACE	82,86	phenylcarboxyamides	BACE	null	23621	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Synthesis and SAR of hydroxyethylamine based phenylcarboxyamides as inhibitors of BACE .
9454800	0	phenylephrine	46,59	Alpha-1A_adrenergic_receptor	0,28	phenylephrine	Alpha-1A adrenergic receptor	MESH:D010656	29413(Tax:10116)	Chemical	Gene	stimulation|nmod|START_ENTITY stimulation|amod|END_ENTITY	Alpha-1A_adrenergic_receptor stimulation with phenylephrine promotes arachidonic_acid release by activation of phospholipase D in rat-1 fibroblasts : inhibition by protein kinase A .
11705990	0	phenylephrine	65,78	CBP	34,37	phenylephrine	CBP	MESH:D010656	1387	Chemical	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	The transcriptional co-activators CBP and p300 are activated via phenylephrine through the p42/p44 MAPK cascade .
3442953	0	phenylephrine	54,67	neuropeptide_Y	11,25	phenylephrine	neuropeptide Y	MESH:D010656	24604(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of neuropeptide_Y on the pressor responses to phenylephrine and to activation of the sympathetic nervous system in anaesthetized rats .
8298798	0	phenylephrine	102,115	neuropeptide_Y	35,49	phenylephrine	neuropeptide Y	MESH:D010656	24604(Tax:10116)	Chemical	Gene	presence|nmod|START_ENTITY artery|nmod|presence analogues|nmod|artery analogues|nsubj|effects effects|nmod|END_ENTITY	Vasoconstrictor effects of various neuropeptide_Y analogues on the rat tail artery in the presence of phenylephrine .
23510923	0	phenylephrine	88,101	p90	0,3	phenylephrine	p90	MESH:D010656	7037	Chemical	Gene	mediate|nmod|START_ENTITY mediate|nsubj|END_ENTITY	p90 -LRB- RSK -RRB- s mediate the activation of ribosomal RNA synthesis by the hypertrophic agonist phenylephrine in adult cardiomyocytes .
3130056	0	phenylephrine	19,32	phospholipase_A	47,62	phenylephrine	phospholipase A	MESH:D010656	57110	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Adenosine inhibits phenylephrine activation of phospholipase_A in hamster brown adipocytes .
15969951	0	phenylethanoid_glycosides	11,36	inducible_nitric_oxide_synthase	85,116	phenylethanoid glycosides	inducible nitric oxide synthase	null	18126(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of phenylethanoid_glycosides from Digitalis purpurea L. on the expression of inducible_nitric_oxide_synthase .
7205869	2	phenylethanolamine	82,100	phenylethanolamine_N-methyltransferase	118,156	phenylethanolamine	phenylethanolamine N-methyltransferase	CHEBI:16343	5409	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Nonaromatic analogues of phenylethanolamine as inhibitors of phenylethanolamine_N-methyltransferase : role of pi-electronic and steric interactions .
7205880	2	phenylethanolamine	82,100	phenylethanolamine_N-methyltransferase	118,156	phenylethanolamine	phenylethanolamine N-methyltransferase	CHEBI:16343	5409	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Nonaromatic analogues of phenylethanolamine as inhibitors of phenylethanolamine_N-methyltransferase : role of hydrophobic and steric interactions .
17401535	2	phenylethylamine	412,428	MAO-B	442,447	phenylethylamine	MAO-B	CHEBI:50048	4129	Chemical	Gene	oxidation|amod|START_ENTITY oxidation|nmod|END_ENTITY	The pH dependence of the kinetic parameters for kynuramine oxidation by purified human MAO-A and for phenylethylamine oxidation by MAO-B in granulocytes at pH values from 5 to 10 was consistent with the protonated amine being used .
16154750	0	phenylethylphosphonamidates	11,38	prostate-specific_membrane_antigen	61,95	phenylethylphosphonamidates	prostate-specific membrane antigen	null	2346	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Optimizing phenylethylphosphonamidates for the inhibition of prostate-specific_membrane_antigen .
6885792	0	phenylhydrazine	28,43	catalase	16,24	phenylhydrazine	catalase	MESH:C030299	847	Chemical	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of catalase by phenylhydrazine .
6802831	0	phenylhydrazine	16,31	cytochrome_P-450	48,64	phenylhydrazine	cytochrome P-450	MESH:C030299	25251(Tax:10116)	Chemical	Gene	reaction|nmod|START_ENTITY reaction|nmod|END_ENTITY	The reaction of phenylhydrazine with microsomal cytochrome_P-450 .
738253	0	phenylhydrazine	10,25	delta-aminolevulinic_acid_dehydratase	29,66	phenylhydrazine	delta-aminolevulinic acid dehydratase	MESH:C030299	25374(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of phenylhydrazine on delta-aminolevulinic_acid_dehydratase in red blood cells .
23456281	0	phenylhydrazine	17,32	tyrosinase	36,46	phenylhydrazine	tyrosinase	MESH:C030299	7299	Chemical	Gene	oxidation|nmod|START_ENTITY oxidation|nmod|END_ENTITY	The oxidation of phenylhydrazine by tyrosinase .
8298579	0	phenylmethanesulfonyl_fluoride	14,44	acetylcholinesterase	82,102	phenylmethanesulfonyl fluoride	acetylcholinesterase	MESH:C003614|MESH:D010664	83817(Tax:10116)	Chemical	Gene	Evaluation|nmod|START_ENTITY END_ENTITY|nsubj|Evaluation	Evaluation of phenylmethanesulfonyl_fluoride -LRB- PMSF -RRB- as a tracer candidate mapping acetylcholinesterase in vivo .
24927150	0	phenylmethylene_hydantoins	33,59	Brk	133,136	phenylmethylene hydantoins	Brk	null	5753	Chemical	Gene	START_ENTITY|nmod|signaling signaling|compound|END_ENTITY	Marine natural products-inspired phenylmethylene_hydantoins with potent in vitro and in vivo antitumor activities via suppression of Brk and FAK signaling .
10825396	0	phenylmethylsulfonyl_fluoride	50,79	acetylcholinesterase	24,44	phenylmethylsulfonyl fluoride	acetylcholinesterase	MESH:D010664	11423(Tax:10090)	Chemical	Gene	studies|nmod|START_ENTITY studies|nmod|END_ENTITY	Inactivation studies of acetylcholinesterase with phenylmethylsulfonyl_fluoride .
25648298	0	phenylpiperazine	13,29	IGF-1R	45,51	phenylpiperazine	IGF-1R	MESH:C031503	3480	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Discovery of phenylpiperazine derivatives as IGF-1R inhibitor with potent antiproliferative properties in vitro .
18220971	0	phenylpiperazines	69,86	melanocortin-4_receptor	90,113	phenylpiperazines	melanocortin-4 receptor	null	4160	Chemical	Gene	START_ENTITY|nmod|antagonists antagonists|amod|END_ENTITY	Studies on the structure-activity relationship of the basic amine of phenylpiperazines as melanocortin-4_receptor antagonists .
19784574	0	phenylpropanamides	48,66	transient_receptor_potential_vanilloid_1	76,116	phenylpropanamides	transient receptor potential vanilloid 1	null	83810(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|antagonists antagonists|amod|END_ENTITY	Design , synthesis , and biological evaluation of phenylpropanamides as novel transient_receptor_potential_vanilloid_1 antagonists .
12951092	0	phenylpropanoids	73,89	TNF-alpha	137,146	phenylpropanoids	TNF-alpha	CHEBI:26004	24835(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Antiallergic principles from Alpinia galanga : structural requirements of phenylpropanoids for inhibition of degranulation and release of TNF-alpha and IL-4 in RBL-2H3 cells .
3961266	0	phenylpropanolamine	44,63	monoamine_oxidase	14,31	phenylpropanolamine	monoamine oxidase	MESH:D010665	29253(Tax:10116)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activity activity|amod|END_ENTITY	Inhibition of monoamine_oxidase activity by phenylpropanolamine , an anorectic agent .
17868324	0	phenylpropanolamine	127,146	neuropeptide_Y	72,86	phenylpropanolamine	neuropeptide Y	MESH:D010665	24604(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Interrupting activator_protein-1 signaling in conscious rats can modify neuropeptide_Y gene expression and feeding behavior of phenylpropanolamine .
25193377	0	phenylpyrazoles	33,48	Rdl	12,15	phenylpyrazoles	Rdl	null	39054(Tax:7227)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of Rdl in resistance to phenylpyrazoles in Drosophila_melanogaster .
15760341	0	phenylthiourea	37,51	tyrosinase	15,25	phenylthiourea	tyrosinase	MESH:D010670	7299	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Degradation of tyrosinase induced by phenylthiourea occurs following Golgi maturation .
11420057	0	phenytoin	47,56	5alpha-reductase	69,85	phenytoin	5alpha-reductase	MESH:D010672	6715	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	The effects of human mast-cell products and of phenytoin on androgen 5alpha-reductase expression in human_gingival_fibroblasts .
142633	0	phenytoin	45,54	ATPase	24,30	phenytoin	ATPase	MESH:D010672	1769	Chemical	Gene	activation|nmod|START_ENTITY activation|nsubj|role role|nmod|END_ENTITY	The role or non-role of ATPase activation by phenytoin in the stabilization of excitable membranes .
12740174	0	phenytoin	11,20	CA3	64,67	phenytoin	CA3	MESH:D010672	54232(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|neurons neurons|compound|END_ENTITY	Effects of phenytoin on morphology and structure of hippocampal CA3 pyramidal neurons of rats in chronic stress .
8874828	0	phenytoin	57,66	CYP2C	10,15	phenytoin	CYP2C	MESH:D010672	1557	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY polymorphisms|nmod|pharmacokinetics polymorphisms|nsubj|Effect Effect|nmod|END_ENTITY	Effect of CYP2C polymorphisms on the pharmacokinetics of phenytoin in Japanese patients with epilepsy .
15155833	0	phenytoin	54,63	Cyp2c29	77,84	phenytoin	Cyp2c29	MESH:D010672	13095(Tax:10090)	Chemical	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	The constitutive active/androstane receptor regulates phenytoin induction of Cyp2c29 .
11496115	0	phenytoin	97,106	Multidrug_resistance-associated_protein	0,39	phenytoin	Multidrug resistance-associated protein	MESH:D010672	8714	Chemical	Gene	levels|nmod|START_ENTITY regulation|nmod|levels involved|nmod|regulation involved|nsubjpass|END_ENTITY	Multidrug_resistance-associated_protein is involved in the regulation of extracellular levels of phenytoin in the brain .
20651846	0	phenytoin	11,20	Satb2	24,29	phenytoin	Satb2	MESH:D010672	212712(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of phenytoin on Satb2 and Hoxa2 gene expressions in mouse embryonic craniofacial tissue .
565245	0	phenytoin	11,20	acetylcholinesterase	24,44	phenytoin	acetylcholinesterase	MESH:D010672	396388(Tax:9031)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effects of phenytoin on acetylcholinesterase activity and cell protein in cultured chick embryonic skeletal muscle .
2463738	0	phenytoin	14,23	calcitonin	49,59	phenytoin	calcitonin	MESH:D010672	24241(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|nmod|END_ENTITY	Inhibition by phenytoin of in vitro secretion of calcitonin from rat thyroid glands and cultured rat C cells .
15123723	0	phenytoin	87,96	constitutive_androstane_receptor	6,38	phenytoin	constitutive androstane receptor	MESH:D010672	9970	Chemical	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Human constitutive_androstane_receptor mediates induction of CYP2B6 gene expression by phenytoin .
183873	0	phenytoin	60,69	cytochrome_P-450_and_b5	14,37	phenytoin	cytochrome P-450 and b5	MESH:D010672	13079(Tax:10090)	Chemical	Gene	liver|nmod|START_ENTITY END_ENTITY|nmod|liver	-LSB- Induction of cytochrome_P-450_and_b5 of the mouse liver by phenytoin during chronic hypoxia -LRB- Fi02 : 0,08 -RRB- -RSB- .
11161626	0	phenytoin	72,81	cytochrome_P450	31,46	phenytoin	cytochrome P450	MESH:D010672	13079(Tax:10090)	Chemical	Gene	control|nmod|START_ENTITY END_ENTITY|nmod|control	Possible function of astrocyte cytochrome_P450 in control of xenobiotic phenytoin in the brain : in vitro studies on murine astrocyte primary cultures .
6113134	0	phenytoin	11,20	gamma-glutamyl_transpeptidase	30,59	phenytoin	gamma-glutamyl transpeptidase	MESH:D010672	92086	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|amod|END_ENTITY	Effects of phenytoin on serum gamma-glutamyl_transpeptidase activity .
8050068	0	pheromone	123,132	Bacteriocin	0,11	pheromone	Bacteriocin	CHEBI:26013	1450190(Tax:1351)	Chemical	Gene	plasmid|nmod|START_ENTITY plasmid|nsubj|END_ENTITY	Bacteriocin plasmid pMB1 of Enterococcus_faecalis : identification of the cell aggregation substance after induction by sex pheromone .
8423774	0	pheromone	98,107	CLN2	55,59	pheromone	CLN2	CHEBI:26013	855819(Tax:4932)	Chemical	Gene	required|nmod|START_ENTITY required|nmod|regulation regulation|nmod|expression expression|compound|END_ENTITY	FAR1 is required for posttranscriptional regulation of CLN2 gene expression in response to mating pheromone .
24023771	0	pheromone	108,117	DopEcR	67,73	pheromone	DopEcR	CHEBI:26013	38539(Tax:7227)	Chemical	Gene	START_ENTITY|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of the G-protein-coupled dopamine/ecdysteroid receptor DopEcR in the behavioral response to sex pheromone in an insect .
17827874	0	pheromone	70,79	ELOVL5	36,42	pheromone	ELOVL5	CHEBI:26013	100861282	Chemical	Gene	START_ENTITY|nsubj|Localization Localization|nmod|END_ENTITY	Localization of the candidate genes ELOVL5 and SCD1 for ` male effect ' pheromone synthesis in goats -LRB- Capra_hircus -RRB- .
8423774	0	pheromone	98,107	FAR1	0,4	pheromone	FAR1	CHEBI:26013	853283(Tax:4932)	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	FAR1 is required for posttranscriptional regulation of CLN2 gene expression in response to mating pheromone .
12031551	0	pheromone	108,117	Fos	62,65	pheromone	Fos	CHEBI:26013	2353	Chemical	Gene	exposure|amod|START_ENTITY influence|nmod|exposure influence|nmod|expression expression|compound|END_ENTITY	Experience facilitates vomeronasal and olfactory influence on Fos expression in medial preoptic area during pheromone exposure or mating in male hamsters .
15973154	0	pheromone	15,24	Fos	33,36	pheromone	Fos	CHEBI:26013	14281(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Age effects on pheromone induced Fos expression in olfactory bulbs of a primate .
9802897	0	pheromone	22,31	Hsp90	0,5	pheromone	Hsp90	CHEBI:26013	855836(Tax:4932)	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Hsp90 is required for pheromone signaling in yeast .
15995198	0	pheromone	37,46	PrgY	109,113	pheromone	PrgY	CHEBI:26013	7072417(Tax:1351)	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Specific control of endogenous cCF10 pheromone by a conserved domain of the pCF10-encoded regulatory protein PrgY in Enterococcus_faecalis .
8552617	0	pheromone	121,130	PrgZ	49,53	pheromone	PrgZ	CHEBI:26013	7072418(Tax:1351)	Chemical	Gene	cCF10|compound|START_ENTITY import|dobj|cCF10 recruits|advcl|import recruits|nsubj|protein protein|appos|END_ENTITY	Enterococcus_faecalis pheromone binding protein , PrgZ , recruits a chromosomal oligopeptide permease system to import sex pheromone cCF10 for induction of conjugation .
8552617	0	pheromone	22,31	PrgZ	49,53	pheromone	PrgZ	CHEBI:26013	7072418(Tax:1351)	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Enterococcus_faecalis pheromone binding protein , PrgZ , recruits a chromosomal oligopeptide permease system to import sex pheromone cCF10 for induction of conjugation .
20714403	0	pheromone	65,74	STIM1	19,24	pheromone	STIM1	CHEBI:26013	100188967(Tax:7091)	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	Functional role of STIM1 and Orai1 in silkmoth -LRB- Bombyx_mori -RRB- sex pheromone production .
15809442	0	pheromone	57,66	V1r	53,56	pheromone	V1r	CHEBI:26013	22296(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Olfactory expression of a single and highly variable V1r pheromone receptor-like gene in fish species .
23026375	0	pheromone	70,79	c-Fos	0,5	pheromone	c-Fos	CHEBI:26013	314322(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|nsubj|END_ENTITY	c-Fos expression during the modulation of sexual_behavior by an alarm pheromone .
15173596	0	pheromone	106,115	desaturase	41,51	pheromone	desaturase	CHEBI:26013	100862798	Chemical	Gene	START_ENTITY|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of a bifunctional fatty-acyl desaturase in the biosynthesis of the silkmoth , Bombyx_mori , sex pheromone .
10485850	0	pheromones	39,49	Far1p	18,23	pheromones	Far1p	MESH:D010675	853283(Tax:4932)	Chemical	Gene	response|nmod|START_ENTITY END_ENTITY|nmod|response	Nuclear export of Far1p in response to pheromones requires the export receptor Msn5p/Ste21p .
26774579	0	phidianidine_B	43,57	PTP1B	79,84	phidianidine B	PTP1B	MESH:C559225	5770	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Design , synthesis and in vitro activity of phidianidine_B derivatives as novel PTP1B inhibitors with specific selectivity .
23295750	1	phlebotomine	41,53	nov.	29,33	phlebotomine	nov.	null	4856	Chemical	Gene	species|compound|START_ENTITY END_ENTITY|appos|species	nov. , a new phlebotomine species -LRB- Diptera : Psychodidae -RRB- from a quartzite cave in Diamantina , state of Minas Gerais , Brazil .
17169565	0	phloridzin_dihydrate	22,42	tyrosinase	91,101	phloridzin dihydrate	tyrosinase	null	7299	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nsubj|effects	Inhibitory effects of phloridzin_dihydrate on the activity of mushroom -LRB- Agaricus bisporus -RRB- tyrosinase .
11565609	0	phlorizin	146,155	SGLT1	102,107	phlorizin	SGLT1	MESH:D010695	25552(Tax:10116)	Chemical	Gene	inhibitor|acl|START_ENTITY Induction|dep|inhibitor Induction|nmod|administration administration|nmod|+ +|compound|END_ENTITY	Induction of ependymal , glial , and neuronal transactivation by intraventricular administration of the SGLT1 Na + - D-glucose cotransporter inhibitor phlorizin .
26086341	0	phlorizin	18,27	SGLT1	84,89	phlorizin	SGLT1	MESH:D010695	6523	Chemical	Gene	domains|amod|START_ENTITY Identification|nmod|domains Identification|dep|END_ENTITY	Identification of phlorizin binding domains in sodium-glucose cotransporter family : SGLT1 as a unique model system .
20349407	0	phlorizin	10,19	SGLT2	23,28	phlorizin	SGLT2	MESH:D010695	64522(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of phlorizin on SGLT2 expression in the kidney of diabetic rats .
24259679	0	phloroglucinols	65,80	pregnane_X_receptor	23,42	phloroglucinols	pregnane X receptor	null	8856	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	No activation of human pregnane_X_receptor by hyperforin-related phloroglucinols .
18771320	0	phloroglucinols	21,36	thyrotropin-releasing_hormone_receptor-2	42,82	phloroglucinols	thyrotropin-releasing hormone receptor-2	null	252859(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|affinity affinity|amod|END_ENTITY	Myrtucommulones_F-I , phloroglucinols with thyrotropin-releasing_hormone_receptor-2 binding affinity from the seeds of Corymbia scabrida .
22473750	0	phlorotannins	41,54	Pancreatic_lipase	0,17	phlorotannins	Pancreatic lipase	CHEBI:71222	5406	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Pancreatic_lipase inhibitory activity of phlorotannins isolated from Eisenia bicyclis .
21585204	0	phlorotannins	53,66	neuraminidase	16,29	phlorotannins	neuraminidase	CHEBI:71222	4758	Chemical	Gene	activity|nmod|START_ENTITY END_ENTITY|dobj|activity	Influenza virus neuraminidase inhibitory activity of phlorotannins from the edible brown_alga_Ecklonia_cava .
11561718	0	phobol_12-myristate-13-acetate	38,68	c-fos	76,81	phobol 12-myristate-13-acetate	c-fos	null	314322(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Differential effects of forskolin and phobol_12-myristate-13-acetate on the c-fos and c-jun mRNA expression in rat C6_glioma cells .
17701898	0	phophatidylinsitol	113,131	PIPKI_gamma	94,105	phophatidylinsitol	PIPKI gamma	null	23396	Chemical	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	Lethal contractural syndrome type 3 -LRB- LCCS3 -RRB- is caused by a mutation in PIP5K1C , which encodes PIPKI_gamma of the phophatidylinsitol pathway .
12558400	0	phorbol	106,113	ABC	87,90	phorbol	ABC	MESH:C033085	10058	Chemical	Gene	system|nmod|START_ENTITY system|compound|END_ENTITY	An asymmetric synthesis of aza analogues of the tricyclic skeleton of daphnane and the ABC ring system of phorbol .
11692264	0	phorbol	24,31	PKCalpha	47,55	phorbol	PKCalpha	MESH:C033085	24680(Tax:10116)	Chemical	Gene	stimulation|amod|START_ENTITY stimulation|nmod|END_ENTITY	Concentration-dependent phorbol stimulation of PKCalpha localization at the nucleus or subplasmalemma in A7r5 cells .
3104713	0	phorbol	10,17	insulin	33,40	phorbol	insulin	MESH:C033085	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of phorbol and glucose on insulin secretion from the human fetal pancreas .
3281671	0	phorbol	49,56	insulin	66,73	phorbol	insulin	MESH:C033085	3630	Chemical	Gene	pancreas|nmod|START_ENTITY stimulation|nmod|pancreas inhibits|nsubj|stimulation inhibits|dobj|secretion secretion|compound|END_ENTITY	Chronic stimulation of human fetal pancreas with phorbol inhibits insulin secretion .
15721302	0	phorbol-12-myristate-13-acetate	14,45	ERK1/2	148,154	phorbol-12-myristate-13-acetate	ERK1/2	CHEBI:37537	5595;5594	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|activation activation|nmod|END_ENTITY	Phorbol ester phorbol-12-myristate-13-acetate promotes anchorage-independent growth and survival of melanomas through MEK-independent activation of ERK1/2 .
1421577	0	phorbol-esters	46,60	p90	19,22	phorbol-esters	p90	MESH:D010703	22042(Tax:10090)	Chemical	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of p90 and p52 in response to phorbol-esters in Swiss/3T3 cells overexpressing protein_kinase_C-alpha .
16210344	7	phorbol_12-myristate_13-acetate	1318,1349	PR-A	1295,1299	phorbol 12-myristate 13-acetate	GC-A	CHEBI:37537	18160(Tax:10090)	Chemical	Gene	absence|nmod|START_ENTITY END_ENTITY|nmod|absence	PR-A in the absence of phorbol_12-myristate_13-acetate was insufficient to induce cGK_II .
10501656	0	phorbol_12-myristate_13-acetate	48,79	SPR1	17,21	phorbol 12-myristate 13-acetate	SPR1	CHEBI:37537	170680	Chemical	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	Re-expression of SPR1 in breast_cancer cells by phorbol_12-myristate_13-acetate -LRB- PMA -RRB- or UV irradiation is mediated by the AP-1 binding site in the SPR1 promoter .
20167259	0	phorbol_12-myristate_13-acetate	59,90	choline_transporter	144,163	phorbol 12-myristate 13-acetate	choline transporter	CHEBI:37537	50690(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	Rapid , transient effects of the protein kinase C activator phorbol_12-myristate_13-acetate on activity and trafficking of the rat high-affinity choline_transporter .
8621697	0	phorbol_12-myristate_13-acetate	69,100	epidermal_growth_factor_receptor	14,46	phorbol 12-myristate 13-acetate	epidermal growth factor receptor	CHEBI:37537	1956	Chemical	Gene	transcription|nmod|START_ENTITY transcription|compound|END_ENTITY	Activation of epidermal_growth_factor_receptor gene transcription by phorbol_12-myristate_13-acetate is mediated by activator_protein_2 .
18992303	0	phorbol_12-myristate_13-acetate	34,65	interleukin-2	88,101	phorbol 12-myristate 13-acetate	interleukin-2	CHEBI:37537	3558	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Prolonged high glucose suppresses phorbol_12-myristate_13-acetate and ionomycin-induced interleukin-2 mRNA expression in Jurkat cells .
8043296	0	phorbol_12-myristate_13-acetate	24,55	phospholipase_A2	106,122	phorbol 12-myristate 13-acetate	phospholipase A2	CHEBI:37537	151056	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activation activation|amod|END_ENTITY	Differential effects of phorbol_12-myristate_13-acetate and diacylglycerols on thromboxane_A2-independent phospholipase_A2 activation in collage-stimulated human platelets .
2975599	0	phorbol_dibutyrate	30,48	C1q	0,3	phorbol dibutyrate	C1q	null	712	Chemical	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	C1q acts synergistically with phorbol_dibutyrate to activate CR1-mediated phagocytosis by human mononuclear phagocytes .
6960690	0	phorbol_diester	12,27	aid	49,52	phorbol diester	aid	null	57379	Chemical	Gene	START_ENTITY|acl|vitro vitro|nmod|END_ENTITY	Exposure to phorbol_diester -LRB- TPA -RRB- in vitro as an aid in the classification of blasts in human myelogenous and lymphoid_leukemias : in vitro differentiation , growth patterns , and ultrastructural observations .
6237101	0	phorbol_diester	85,100	interleukin_2	57,70	phorbol diester	interleukin 2	null	3558	Chemical	Gene	receptor|nmod|START_ENTITY receptor|amod|END_ENTITY	Induction of expression and phosphorylation of the human interleukin_2 receptor by a phorbol_diester .
3202146	0	phorbol_diester	43,58	myosin	17,23	phorbol diester	myosin	null	79784	Chemical	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	-LSB- Ca2 + -RSB- - dependent myosin phosphorylation in phorbol_diester stimulated smooth muscle contraction .
2154205	0	phorbol_ester	160,173	Angiotensin_II	0,14	phorbol ester	Angiotensin II	CHEBI:37532	24179(Tax:10116)	Chemical	Gene	modulated|nmod|START_ENTITY response|acl|modulated breakdown|dep|response breakdown|amod|END_ENTITY	Angiotensin_II and bradykinin_stimulate_phosphoinositide breakdown in intact rat kidney glomeruli but not in proximal tubules : glomerular response modulated by phorbol_ester .
3002350	0	phorbol_ester	60,73	Atrial_natriuretic_peptide	0,26	phorbol ester	Atrial natriuretic peptide	CHEBI:37532	24602(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY secretion|dep|effect secretion|amod|END_ENTITY	Atrial_natriuretic_peptide secretion : synergistic effect of phorbol_ester and A23187 .
11850819	0	phorbol_ester	40,53	C-Jun_N-terminal_kinase	0,23	phorbol ester	C-Jun N-terminal kinase	CHEBI:37532	5599	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	C-Jun_N-terminal_kinase is required for phorbol_ester - and thapsigargin-induced apoptosis in the androgen responsive_prostate_cancer cell line LNCaP .
10941932	0	phorbol_ester	95,108	CD4	44,47	phorbol ester	CD4	CHEBI:37532	920	Chemical	Gene	primed|nmod|START_ENTITY primed|nsubj|level level|nmod|co-down-modulation co-down-modulation|nmod|END_ENTITY	Differential level in co-down-modulation of CD4 and CXCR4 primed by HIV-1 gp120 in response to phorbol_ester , PMA , among HIV-1 isolates .
1349321	0	phorbol_ester	30,43	CD4	138,141	phorbol ester	CD4	CHEBI:37532	920	Chemical	Gene	accelerates|nsubj|START_ENTITY accelerates|xcomp|cycle cycle|nmod|cells cells|nummod|END_ENTITY	A protein kinase C-activating phorbol_ester accelerates the T cell antigen receptor-stimulated phosphatidylinositol cycle in normal human CD4 + T cells .
1971792	0	phorbol_ester	68,81	CD4	0,3	phorbol ester	CD4	CHEBI:37532	12504(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY fragmentation|acl|induced susceptible|nmod|fragmentation susceptible|nsubj|thymocytes thymocytes|compound|END_ENTITY	CD4 + CD8 + thymocytes are susceptible to DNA fragmentation induced by phorbol_ester , calcium ionophore and anti-CD3 antibody .
2265712	0	phorbol_ester	33,46	CD4	17,20	phorbol ester	CD4	CHEBI:37532	920	Chemical	Gene	turnover|nmod|START_ENTITY turnover|compound|END_ENTITY	Surface membrane CD4 turnover in phorbol_ester stimulated T-lymphocytes .
7857297	0	phorbol_ester	78,91	CD4	68,71	phorbol ester	CD4	CHEBI:37532	920	Chemical	Gene	treatment|compound|START_ENTITY END_ENTITY|nmod|treatment	Signal transduction in SF9 insect cells : endocytosis of recombinant CD4 after phorbol_ester treatment .
9092538	0	phorbol_ester	41,54	Cbl	26,29	phorbol ester	Cbl	CHEBI:37532	867	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Serine phosphorylation of Cbl induced by phorbol_ester enhances its association with 14-3-3 proteins in T cells via a novel serine-rich 14-3-3-binding motif .
18577431	0	phorbol_ester	134,147	Egr-1	90,95	phorbol ester	Egr-1	CHEBI:37532	407125(Tax:9913)	Chemical	Gene	regulation|nmod|START_ENTITY roles|nmod|regulation roles|nmod|END_ENTITY	Characterization of the bovine angiotensin_converting_enzyme promoter : essential roles of Egr-1 , ATF-2 and Ets-1 in the regulation by phorbol_ester .
2588913	0	phorbol_ester	84,97	Epidermal_growth_factor_receptor	1,33	phorbol ester	Epidermal growth factor receptor	CHEBI:37532	1956	Chemical	Gene	-RSB-|compound|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- Epidermal_growth_factor_receptor of human liver_cancer cells and its modulation by phorbol_ester -RSB- .
8206325	0	phorbol_ester	67,80	GnRH	43,47	phorbol ester	GnRH	CHEBI:37532	25194(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Evidence for transcriptional inhibition of GnRH gene expression by phorbol_ester at a proximal promoter region .
8245456	0	phorbol_ester	54,67	IL-5	19,23	phorbol ester	IL-5	CHEBI:37532	16191(Tax:10090)	Chemical	Gene	synergistically|nmod|START_ENTITY synergistically|compound|END_ENTITY	cAMP activates the IL-5 promoter synergistically with phorbol_ester through the signaling pathway involving protein kinase A in mouse thymoma line EL-4 .
2661946	0	phorbol_ester	50,63	Insulin	0,7	phorbol ester	Insulin	CHEBI:37532	396145(Tax:9031)	Chemical	Gene	effect|nmod|START_ENTITY reverses|dobj|effect reverses|nsubj|END_ENTITY	Insulin reverses the growth_retardation effect of phorbol_ester in chicken embryos during organogenesis .
6229253	0	phorbol_ester	39,52	Insulin	0,7	phorbol ester	Insulin	CHEBI:37532	3630	Chemical	Gene	effects|nmod|START_ENTITY secretion|dep|effects secretion|compound|END_ENTITY	Insulin secretion : combined effects of phorbol_ester and A23187 .
11174002	0	phorbol_ester	57,70	MMP-9	40,45	phorbol ester	MMP-9	CHEBI:37532	4318	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Prostacyclin inhibits the production of MMP-9 induced by phorbol_ester through protein kinase A activation , but does not affect the production of MMP-2 in Human cultured mesangial cells .
25981923	0	phorbol_ester	163,176	MUC5AC	139,145	phorbol ester	MUC5AC	CHEBI:37532	4586	Chemical	Gene	factor|compound|START_ENTITY induced|nmod|factor mucin|acl|induced mucin|compound|END_ENTITY	Dioscin and methylprotodioscin isolated from the root of Asparagus cochinchinensis suppressed the gene expression and production of airway MUC5AC mucin induced by phorbol_ester and growth factor .
25981923	0	phorbol_ester	163,176	MUC5AC	139,145	phorbol ester	MUC5AC	CHEBI:37532	4586	Chemical	Gene	factor|compound|START_ENTITY induced|nmod|factor mucin|acl|induced mucin|compound|END_ENTITY	Dioscin and methylprotodioscin isolated from the root of Asparagus cochinchinensis suppressed the gene expression and production of airway MUC5AC mucin induced by phorbol_ester and growth factor .
9697857	0	phorbol_ester	26,39	Munc13-1	0,8	phorbol ester	Munc13-1	CHEBI:37532	23025	Chemical	Gene	receptor|compound|START_ENTITY receptor|nsubj|END_ENTITY	Munc13-1 is a presynaptic phorbol_ester receptor that enhances neurotransmitter release .
12297018	0	phorbol_ester	64,77	NF-kappaB	34,43	phorbol ester	NF-kappaB	CHEBI:37532	4790	Chemical	Gene	induced|nmod|START_ENTITY activation|acl|induced activation|nmod|END_ENTITY	Curcumin suppresses activation of NF-kappaB and AP-1 induced by phorbol_ester in cultured human promyelocytic_leukemia cells .
9888864	0	phorbol_ester	66,79	PAI-1	41,46	phorbol ester	PAI-1	CHEBI:37532	5054	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	On the role of c-Jun in the induction of PAI-1 gene expression by phorbol_ester , serum , and IL-1alpha in HepG2 cells .
9192514	0	phorbol_ester	27,40	Parathyroid_hormone	0,19	phorbol ester	Parathyroid hormone	CHEBI:37532	24694(Tax:10116)	Chemical	Gene	stimulation|compound|START_ENTITY END_ENTITY|nmod|stimulation	Parathyroid_hormone versus phorbol_ester stimulation of activator_protein-1 gene family members in rat_osteosarcoma cells .
10514283	0	phorbol_ester	84,97	Protein_kinase_C	0,16	phorbol ester	Protein kinase C	CHEBI:37532	112476	Chemical	Gene	pharmacophores|compound|START_ENTITY set|nmod|pharmacophores containing|dobj|set templates|acl|containing ligands|advcl|templates ligands|nsubj|END_ENTITY	Protein_kinase_C ligands based on tetrahydrofuran templates containing a new set of phorbol_ester pharmacophores .
10705998	0	phorbol_ester	84,97	Protein_kinase_C	0,16	phorbol ester	Protein kinase C	CHEBI:37532	24681(Tax:10116)	Chemical	Gene	displaying|nmod|START_ENTITY cells|acl|displaying isoforms|nmod|cells isoforms|nsubj|END_ENTITY	Protein_kinase_C isoforms in pituitary cells displaying differential sensitivity to phorbol_ester .
12231451	0	phorbol_ester	67,80	Protein_kinase_C	0,16	phorbol ester	Protein kinase C	CHEBI:37532	100302324(Tax:10141)	Chemical	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Protein_kinase_C mediates potentiation of synaptic transmission by phorbol_ester at parallel fibers in the dorsal cochlear nucleus .
1380299	0	phorbol_ester	146,159	Protein_kinase_C	0,16	phorbol ester	Protein kinase C	CHEBI:37532	112476	Chemical	Gene	stimulation|nmod|START_ENTITY pump|dobj|stimulation stimulates|parataxis|pump stimulates|nsubj|END_ENTITY	Protein_kinase_C stimulates dense tubular Ca2 + uptake in the intact human platelet by increasing the Vm of the Ca -LRB- 2 + -RRB- - ATPase pump : stimulation by phorbol_ester , inhibition by calphostin_C .
1917958	0	phorbol_ester	30,43	Protein_kinase_C	0,16	phorbol ester	Protein kinase C	CHEBI:37532	112476	Chemical	Gene	domains|amod|START_ENTITY contains|dobj|domains contains|nsubj|END_ENTITY	Protein_kinase_C contains two phorbol_ester binding domains .
3196326	0	phorbol_ester	46,59	Protein_kinase_C	0,16	phorbol ester	Protein kinase C	CHEBI:37532	112476	Chemical	Gene	promoter|compound|START_ENTITY activities|nmod|promoter activities|amod|END_ENTITY	Protein_kinase_C activities and bindings of a phorbol_ester tumor promoter in 41 cell lines .
10355626	0	phorbol_ester	58,71	Protein_kinase_C-alpha	0,22	phorbol ester	Protein kinase C-alpha	CHEBI:37532	5578	Chemical	Gene	produces|nmod|START_ENTITY produces|nsubj|END_ENTITY	Protein_kinase_C-alpha produces reciprocal effects on the phorbol_ester stimulated tyrosine phosphorylation of a 50 kDa kinase in Jurkat cells .
12469196	0	phorbol_ester	37,50	Protein_kinase_C-alpha	0,22	phorbol ester	Protein kinase C-alpha	CHEBI:37532	282001(Tax:9913)	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Protein_kinase_C-alpha activation by phorbol_ester induces secretion of gelatinase_B / MMP-9 through ERK_1 / 2 pathway in capillary endothelial cells .
8781558	0	phorbol_ester	65,78	Protein_kinase_C-alpha	0,22	phorbol ester	Protein kinase C-alpha	CHEBI:37532	24680(Tax:10116)	Chemical	Gene	phosphorylated|xcomp|START_ENTITY phosphorylated|nsubj|END_ENTITY	Protein_kinase_C-alpha is multiply phosphorylated in response to phorbol_ester stimulation of PC12 cells .
14532295	0	phorbol_ester	48,61	RasGRP1	0,7	phorbol ester	RasGRP1	CHEBI:37532	19419(Tax:10090)	Chemical	Gene	represents|dobj|START_ENTITY represents|nsubj|END_ENTITY	RasGRP1 represents a novel non-protein_kinase_C phorbol_ester signaling pathway in mouse epidermal keratinocytes .
10914330	0	phorbol_ester	78,91	SP-A	112,116	phorbol ester	SP-A	CHEBI:37532	729238	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|activity activity|amod|END_ENTITY	Induction of AP-1 binding to intron 1 of SP-A1 and SP-A2 is implicated in the phorbol_ester inhibition of human SP-A promoter activity .
10783132	0	phorbol_ester	91,104	SPRR1	66,71	phorbol ester	SPRR1	CHEBI:37532	6699	Chemical	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Induction of cell cornification and enhanced squamous-cell marker SPRR1 gene expression by phorbol_ester are regulated by different signaling pathways in human conducting airway epithelial cells .
8484784	0	phorbol_ester	47,60	THP-1	30,35	phorbol ester	THP-1	CHEBI:37532	2736	Chemical	Gene	cells|nmod|START_ENTITY cells|compound|END_ENTITY	Differentiation of monocytoid THP-1 cells with phorbol_ester induces expression of prostaglandin_endoperoxide synthase-1 -LRB- COX-1 -RRB- .
10913371	0	phorbol_ester	96,109	TIS11	59,64	phorbol ester	TIS11	CHEBI:37532	79426(Tax:10116)	Chemical	Gene	function|nmod|START_ENTITY function|nmod|END_ENTITY	Transcriptional activation function of zinc finger protein TIS11 and its negative regulation by phorbol_ester .
11384204	5	phorbol_ester	850,863	TNF-alpha	887,896	phorbol ester	TNF-alpha	CHEBI:37532	7124	Chemical	Gene	secretion|amod|START_ENTITY secretion|amod|END_ENTITY	CsA -LRB- 100 ng/ml -RRB- potently inhibited phorbol_ester - and tachykinin-evoked TNF-alpha secretion .
11369514	0	phorbol_ester	47,60	Tumor_necrosis_factor-alpha	0,27	phorbol ester	Tumor necrosis factor-alpha	CHEBI:37532	7124	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Tumor_necrosis_factor-alpha is induced through phorbol_ester -- and glycated human albumin-dependent pathway in THP-1 cells .
12755693	0	phorbol_ester	127,140	Tumor_necrosis_factor-alpha	0,27	phorbol ester	Tumor necrosis factor-alpha	CHEBI:37532	7124	Chemical	Gene	stimulation|compound|START_ENTITY degraded|nmod|stimulation form|acl:relcl|degraded processed|nmod|form processed|nsubjpass|enzyme enzyme|amod|END_ENTITY	Tumor_necrosis_factor-alpha converting enzyme is processed by proprotein-convertases to its mature form which is degraded upon phorbol_ester stimulation .
11408617	0	phorbol_ester	21,34	activator_protein_1	50,69	phorbol ester	activator protein 1	CHEBI:37532	3725	Chemical	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Resveratrol inhibits phorbol_ester and UV-induced activator_protein_1 activation by interfering with mitogen-activated protein kinase pathways .
2829820	0	phorbol_ester	21,34	angiotensin_II	38,52	phorbol ester	angiotensin II	CHEBI:37532	24179(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Different effects of phorbol_ester on angiotensin_II - and stable GTP analogue-induced activation of polyphosphoinositide phosphodiesterase in membranes isolated from rat renal mesangial cells .
9563852	0	phorbol_ester	145,158	annexin_1	172,181	phorbol ester	annexin 1	CHEBI:37532	301	Chemical	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	Human annexin_1 is highly expressed during the differentiation of the epithelial cell line A 549 : involvement of nuclear factor interleukin 6 in phorbol_ester induction of annexin_1 .
1826618	0	phorbol_ester	10,23	atrial_natriuretic_peptide	42,68	phorbol ester	atrial natriuretic peptide	CHEBI:37532	24602(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|release release|nmod|END_ENTITY	Effect of phorbol_ester on the release of atrial_natriuretic_peptide from the hypertrophied rat myocardium .
11598794	0	phorbol_ester	39,52	c-myc	19,24	phorbol ester	c-myc	CHEBI:37532	4609	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Down-modulation of c-myc expression by phorbol_ester protects CEM T leukaemia cells from starvation-induced apoptosis : role of ornithine_decarboxylase and polyamines .
3152600	0	phorbol_ester	43,56	c-myc	14,19	phorbol ester	c-myc	CHEBI:37532	4609	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Modulation of c-myc oncogene expression by phorbol_ester and interferon-gamma : appraisal by flow cytometry .
7849624	0	phorbol_ester	69,82	c-myc	34,39	phorbol ester	c-myc	CHEBI:37532	4609	Chemical	Gene	12-0-tetradecanoyl_phorbol-13-acetate|compound|START_ENTITY expression|nmod|12-0-tetradecanoyl_phorbol-13-acetate expression|amod|END_ENTITY	Regulation of cell growth and the c-myc proto-oncogene expression by phorbol_ester 12-0-tetradecanoyl_phorbol-13-acetate -LRB- TPA -RRB- in the androgen-independent human prostatic JCA-1 cells .
1446649	0	phorbol_ester	12,25	endothelin-1	44,56	phorbol ester	endothelin-1	CHEBI:37532	1906	Chemical	Gene	START_ENTITY|nmod|release release|amod|END_ENTITY	Effect of a phorbol_ester on immunoreactive endothelin-1 release from cultured porcine aortic endothelial cells .
7736562	0	phorbol_ester	10,23	endothelin-1	91,103	phorbol ester	endothelin-1	CHEBI:37532	1906	Chemical	Gene	Effect|nmod|START_ENTITY induced|nsubj|Effect induced|nmod|cells cells|amod|END_ENTITY	Effect of phorbol_ester on phosphoinositide hydrolysis and calcium mobilization induced by endothelin-1 in cultured canine tracheal smooth muscle cells .
1656952	0	phorbol_ester	43,56	erythropoietin	14,28	phorbol ester	erythropoietin	CHEBI:37532	2056	Chemical	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	Inhibition of erythropoietin production by phorbol_ester is associated with down-regulation of protein_kinase_C-alpha isoenzyme in hepatoma cells .
12452835	0	phorbol_ester	128,141	gp-340	65,71	phorbol ester	gp-340	CHEBI:37532	1755	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	The scavenger receptor , cysteine-rich domain-containing molecule gp-340 is differentially regulated in epithelial cell lines by phorbol_ester .
7980519	0	phorbol_ester	31,44	heparin-binding_EGF-like_growth_factor	95,133	phorbol ester	heparin-binding EGF-like growth factor	CHEBI:37532	1839	Chemical	Gene	Biosynthesis|nmod|START_ENTITY surface-associated|nsubj|Biosynthesis surface-associated|dobj|form form|nmod|END_ENTITY	Biosynthesis and processing by phorbol_ester of the cells surface-associated precursor form of heparin-binding_EGF-like_growth_factor .
9244191	0	phorbol_ester	67,80	heparin-binding_EGF-like_growth_factor	14,52	phorbol ester	heparin-binding EGF-like growth factor	CHEBI:37532	1839	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of heparin-binding_EGF-like_growth_factor expression by phorbol_ester in a human hepatoma-derived cell line .
11301043	0	phorbol_ester	11,24	histidine_decarboxylase	56,79	phorbol ester	histidine decarboxylase	CHEBI:37532	3067	Chemical	Gene	treatment|compound|START_ENTITY Effects|nmod|treatment Effects|nmod|END_ENTITY	Effects of phorbol_ester and dexamethasone treatment on histidine_decarboxylase and ornithine_decarboxylase in basophilic cells .
15774549	0	phorbol_ester	66,79	interferon-gamma	35,51	phorbol ester	interferon-gamma	CHEBI:37532	15978(Tax:10090)	Chemical	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	2-Arachidonoyl-glycerol suppresses interferon-gamma production in phorbol_ester / ionomycin-activated mouse splenocytes independent of CB1 or CB2 .
1903142	0	phorbol_ester	155,168	interferon-gamma	16,32	phorbol ester	interferon-gamma	CHEBI:37532	3458	Chemical	Gene	effects|nmod|START_ENTITY cytokines|nmod|effects potencies|nmod|cytokines Upregulation|dep|potencies Upregulation|nmod|END_ENTITY	Upregulation of interferon-gamma binding by tumor_necrosis_factor and lymphotoxin : disparate potencies of the cytokines and modulation of their effects by phorbol_ester .
11304541	0	phorbol_ester	87,100	interferon_regulatory_factor-2	32,62	phorbol ester	interferon regulatory factor-2	CHEBI:37532	3660	Chemical	Gene	treatment|compound|START_ENTITY treatment|amod|END_ENTITY	Coactivator p300 acetylates the interferon_regulatory_factor-2 in U937 cells following phorbol_ester treatment .
8027056	0	phorbol_ester	43,56	interleukin-1_alpha	84,103	phorbol ester	interleukin-1 alpha	CHEBI:37532	16175(Tax:10090)	Chemical	Gene	induction|compound|START_ENTITY induction|nmod|mRNA mRNA|amod|END_ENTITY	Signal transduction pathway -LRB- s -RRB- involved in phorbol_ester and autocrine induction of interleukin-1_alpha mRNA in murine keratinocytes .
2400789	0	phorbol_ester	87,100	interleukin-2	67,80	phorbol ester	interleukin-2	CHEBI:37532	3558	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	T-cell restricted and unrestricted expression of transfected human interleukin-2 gene : phorbol_ester - and calcium-inducible versus constitutive expression .
7999066	0	phorbol_ester	104,117	interleukin-2	49,62	phorbol ester	interleukin-2	CHEBI:37532	3558	Chemical	Gene	synergism|nmod|START_ENTITY enhances|nmod|synergism enhances|dobj|activity activity|compound|END_ENTITY	Human_immunodeficiency_virus_type-1 tat enhances interleukin-2 promoter activity through synergism with phorbol_ester and calcium-mediated activation of the NF-AT cis-regulatory motif .
3081875	0	phorbol_ester	13,26	mucin	63,68	phorbol ester	mucin	CHEBI:37532	65202(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|nmod|END_ENTITY	Effects of a phorbol_ester and diacylglycerols on secretion of mucin and arginine esterase by rat submandibular gland cells .
2266135	0	phorbol_ester	2,15	nPKC_eta	41,49	phorbol ester	nPKC eta	CHEBI:37532	18755(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	A phorbol_ester receptor/protein kinase , nPKC_eta , a new member of the protein kinase C family predominantly expressed in lung and skin .
9195956	1	phorbol_ester	83,96	nuclear_factor_kappaB	111,132	phorbol ester	nuclear factor kappaB	CHEBI:37532	4790	Chemical	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Ceramide inhibits phorbol_ester activation of nuclear_factor_kappaB .
16149074	0	phorbol_ester	83,96	p38	101,104	phorbol ester	p38	CHEBI:37532	1432	Chemical	Gene	START_ENTITY|nmod|protein protein|amod|END_ENTITY	Inhibition of low_density_lipoprotein_receptor expression by long-term exposure to phorbol_ester via p38 mitogen-activated protein kinase pathway .
21533428	0	phorbol_ester	28,41	p53	147,150	phorbol ester	p53	CHEBI:37532	301300(Tax:10116)	Chemical	Gene	kinase|nmod|START_ENTITY Activation|nmod|kinase correlate|nsubj|Activation correlate|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Activation of Raf kinase by phorbol_ester does not correlate with enhanced phosphorylation or transactivation activity of tumor suppressor protein p53 .
7961944	0	phorbol_ester	32,45	p53	77,80	phorbol ester	p53	CHEBI:37532	301300(Tax:10116)	Chemical	Gene	activator|appos|START_ENTITY cooperates|nsubj|activator cooperates|nmod|species species|compound|END_ENTITY	The protein kinase C activator , phorbol_ester , cooperates with the wild-type p53 species of Ras-transformed embryo fibroblasts growth arrest .
8018565	0	phorbol_ester	16,29	p53	61,64	phorbol ester	p53	CHEBI:37532	7157	Chemical	Gene	down-modulates|nsubj|START_ENTITY down-modulates|dobj|level level|compound|END_ENTITY	Tumor-promoting phorbol_ester transiently down-modulates the p53 level and blocks the cell cycle .
8700548	0	phorbol_ester	134,147	p53	7,10	phorbol ester	p53	CHEBI:37532	22060(Tax:10090)	Chemical	Gene	o-tetradecanoylphorbol_13-acetate|compound|START_ENTITY phosphorylated|nmod|o-tetradecanoylphorbol_13-acetate phosphorylated|nsubjpass|END_ENTITY	Murine p53 is phosphorylated within the PAb421 epitope by protein_kinase_C in vitro , but not in vivo , even after stimulation with the phorbol_ester o-tetradecanoylphorbol_13-acetate .
9208127	0	phorbol_ester	61,74	p53	15,18	phorbol ester	p53	CHEBI:37532	22060(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Attenuation of p53 expression and Bax down-regulation during phorbol_ester mediated inhibition of apoptosis .
3686356	0	phorbol_ester	14,27	parathyroid_hormone	51,70	phorbol ester	parathyroid hormone	CHEBI:37532	5741	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|release release|nmod|END_ENTITY	The effect of phorbol_ester on in vitro release of parathyroid_hormone from abnormal human parathyroid cells .
14670086	0	phorbol_ester	117,130	peroxisome_proliferator_activated_receptor_delta	4,52	phorbol ester	peroxisome proliferator activated receptor delta	CHEBI:37532	5467	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	The peroxisome_proliferator_activated_receptor_delta is required for the differentiation of THP-1 monocytic cells by phorbol_ester .
9024981	0	phorbol_ester	11,24	phospholipase_D	28,43	phorbol ester	phospholipase D	CHEBI:37532	23646	Chemical	Gene	START_ENTITY|nmod|protein protein|amod|END_ENTITY	Effects of phorbol_ester on phospholipase_D and mitogen-activated protein kinase activities in T-lymphocyte cell lines .
7503727	0	phorbol_ester	47,60	prohormone_convertase-1	18,41	phorbol ester	prohormone convertase-1	CHEBI:37532	5122	Chemical	Gene	Downregulation|nmod|START_ENTITY Downregulation|nmod|END_ENTITY	Downregulation of prohormone_convertase-1 by a phorbol_ester .
12456804	0	phorbol_ester	116,129	prolactin	152,161	phorbol ester	prolactin	CHEBI:37532	24683(Tax:10116)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|promoter promoter|compound|END_ENTITY	Role of specific protein_kinase_C isozymes in mediating epidermal growth factor , thyrotropin-releasing_hormone , and phorbol_ester regulation of the rat prolactin promoter in GH4/GH4C1 pituitary cells .
3930485	0	phorbol_ester	24,37	prolactin	103,112	phorbol ester	prolactin	CHEBI:37532	24683(Tax:10116)	Chemical	Gene	thyrotropin-releasing_hormone|compound|START_ENTITY mechanisms|nmod|thyrotropin-releasing_hormone mechanisms|nmod|transcription transcription|amod|END_ENTITY	Molecular mechanisms of phorbol_ester , thyrotropin-releasing_hormone , and growth_factor stimulation of prolactin gene transcription .
8320275	0	phorbol_ester	68,81	prolactin_receptor	14,32	phorbol ester	prolactin receptor	CHEBI:37532	5618	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of prolactin_receptor expression by the tumour promoting phorbol_ester 12-O-tetradecanoylphorbol-13-acetate in human breast_cancer cells .
3479244	0	phorbol_ester	11,24	protein_kinase_C	65,81	phorbol ester	protein kinase C	CHEBI:37532	112476	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of phorbol_ester on translocation and down-regulation of protein_kinase_C and phosphorylation of endogenous proteins in human acute myeloid_leukemia cell line KG-1 and its phorbol_ester-resistant subline KG-1a .
8850328	0	phorbol_ester	64,77	protein_kinase_C	104,120	phorbol ester	protein kinase C	CHEBI:37532	24681(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of repeated administration of a kappa-opioid agonist on phorbol_ester binding to membrane-bound protein_kinase_C in rat brain .
1444457	0	phorbol_ester	34,47	protein_kinase_C-alpha	84,106	phorbol ester	protein kinase C-alpha	CHEBI:37532	5578	Chemical	Gene	cells|nmod|START_ENTITY Differentiation|nmod|cells correlated|nsubjpass|Differentiation correlated|nmod|up-regulation up-regulation|nmod|END_ENTITY	Differentiation of HL-60 cells by phorbol_ester is correlated with up-regulation of protein_kinase_C-alpha .
1656952	0	phorbol_ester	43,56	protein_kinase_C-alpha	95,117	phorbol ester	protein kinase C-alpha	CHEBI:37532	5578	Chemical	Gene	production|nmod|START_ENTITY Inhibition|nmod|production associated|nsubjpass|Inhibition associated|nmod|down-regulation down-regulation|nmod|isoenzyme isoenzyme|amod|END_ENTITY	Inhibition of erythropoietin production by phorbol_ester is associated with down-regulation of protein_kinase_C-alpha isoenzyme in hepatoma cells .
1953788	0	phorbol_ester	86,99	protein_kinase_C-alpha	25,47	phorbol ester	protein kinase C-alpha	CHEBI:37532	24680(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY isozymes|nmod|treatment isozymes|nsubj|recovery recovery|nmod|epsilon epsilon|amod|END_ENTITY	Differential recovery of protein_kinase_C-alpha and - epsilon isozymes after long-term phorbol_ester treatment in rat renal mesangial cells .
8467904	0	phorbol_ester	87,100	protein_kinase_C-alpha	19,41	phorbol ester	protein kinase C-alpha	CHEBI:37532	5578	Chemical	Gene	factor|dep|START_ENTITY enhances|dobj|factor enhances|nsubj|Over-expression Over-expression|nmod|END_ENTITY	Over-expression of protein_kinase_C-alpha enhances platelet-derived growth factor - and phorbol_ester - but not calcium ionophore-induced formation of prostaglandins in NIH 3T3 fibroblasts .
1672274	0	phorbol_ester	53,66	pyroglutamyl_peptidase_II	14,39	phorbol ester	pyroglutamyl peptidase II	CHEBI:37532	29953	Chemical	Gene	synthesis|nmod|START_ENTITY synthesis|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of pyroglutamyl_peptidase_II synthesis by phorbol_ester in the Y-79 retinoblastoma cell .
1979029	0	phorbol_ester	121,134	pyroglutamyl_peptidase_II	42,67	phorbol ester	pyroglutamyl peptidase II	CHEBI:37532	29953	Chemical	Gene	inactivation|nmod|START_ENTITY inactivation|nmod|END_ENTITY	Rapid inactivation and phosphorylation of pyroglutamyl_peptidase_II in Y-79 human retinoblastoma cells after exposure to phorbol_ester .
2747640	0	phorbol_ester	55,68	serum_amyloid_A	88,103	phorbol ester	serum amyloid A	CHEBI:37532	6287	Chemical	Gene	induction|compound|START_ENTITY induction|nmod|expression expression|compound|END_ENTITY	Identification of cis-acting sequences responsible for phorbol_ester induction of human serum_amyloid_A gene expression via a nuclear factor kappaB-like transcription factor .
8126384	0	phorbol_ester	11,24	tissue-type_plasminogen_activator	28,61	phorbol ester	tissue-type plasminogen activator	CHEBI:37532	5327	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|amod|END_ENTITY	-LSB- Effect of phorbol_ester on tissue-type_plasminogen_activator -LRB- t-PA -RRB- secretion in endometrial_carcinoma cell line in vitro -RSB- .
1903142	0	phorbol_ester	155,168	tumor_necrosis_factor	44,65	phorbol ester	tumor necrosis factor	CHEBI:37532	7124	Chemical	Gene	effects|nmod|START_ENTITY cytokines|nmod|effects potencies|nmod|cytokines Upregulation|dep|potencies Upregulation|nmod|interferon-gamma interferon-gamma|nmod|END_ENTITY	Upregulation of interferon-gamma binding by tumor_necrosis_factor and lymphotoxin : disparate potencies of the cytokines and modulation of their effects by phorbol_ester .
2494431	0	phorbol_ester	109,122	tumor_necrosis_factor	68,89	phorbol ester	tumor necrosis factor	CHEBI:37532	7124	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Role of arachidonic_acid metabolism in transcriptional induction of tumor_necrosis_factor gene expression by phorbol_ester .
1545816	0	phorbol_ester	73,86	tumor_necrosis_factor_alpha	32,59	phorbol ester	tumor necrosis factor alpha	CHEBI:37532	7124	Chemical	Gene	responsiveness|compound|START_ENTITY confers|dobj|responsiveness confers|nsubj|region region|nmod|gene gene|compound|END_ENTITY	The core promoter region of the tumor_necrosis_factor_alpha gene confers phorbol_ester responsiveness to upstream transcriptional activators .
2056282	0	phorbol_ester	53,66	tumor_necrosis_factor_alpha	6,33	phorbol ester	tumor necrosis factor alpha	CHEBI:37532	7124	Chemical	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	Human tumor_necrosis_factor_alpha gene regulation in phorbol_ester stimulated T and B cell lines .
2213017	0	phorbol_ester	154,167	urokinase-type_plasminogen_activator	13,49	phorbol ester	urokinase-type plasminogen activator	CHEBI:37532	5328	Chemical	Gene	stimulation|nmod|START_ENTITY Synthesis|dep|stimulation Synthesis|nmod|END_ENTITY	Synthesis of urokinase-type_plasminogen_activator and of type-1 plasminogen activator inhibitor in neuronal cultures of human fetal brain : stimulation by phorbol_ester .
8617995	0	phorbol_ester	144,157	urokinase-type_plasminogen_activator	27,63	phorbol ester	urokinase-type plasminogen activator	CHEBI:37532	18792(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Differential expression of urokinase-type_plasminogen_activator , its receptor , and inhibitors in mouse skin after exposure to a tumor-promoting phorbol_ester .
18505338	0	phorbol_ester	17,30	v-Myb	0,5	phorbol ester	v-Myb	CHEBI:37532	4602	Chemical	Gene	START_ENTITY|nsubj|suppresses suppresses|amod|END_ENTITY	v-Myb suppresses phorbol_ester - and modifies retinoic_acid-induced differentiation of human promonocytic U937 cells .
10978519	0	phorbol_ester	67,80	vimentin	121,129	phorbol ester	vimentin	CHEBI:37532	22352(Tax:10090)	Chemical	Gene	12-O-tetradecanoylphorbol-13-acetate|compound|START_ENTITY 12-O-tetradecanoylphorbol-13-acetate|nmod|expression expression|compound|END_ENTITY	Similar effects of electroporational stress and treatment with the phorbol_ester 12-O-tetradecanoylphorbol-13-acetate on vimentin expression in mouse_plasmacytoma cells .
3838316	0	phorbol_ester	82,95	vimentin	26,34	phorbol ester	vimentin	CHEBI:37532	7431	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of cytoskeletal vimentin and actin gene expression by a tumor-promoting phorbol_ester in the human leukemic cell line K562 .
7547512	0	phorbol_ester	57,70	vimentin	22,30	phorbol ester	vimentin	CHEBI:37532	420519(Tax:9031)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Regulation of chicken vimentin gene expression by serum , phorbol_ester , and growth factors : identification of a novel fibroblast growth factor-inducible element .
11169972	0	phorbol_ester_TPA	60,77	cyclin_D1	14,23	phorbol ester TPA	cyclin D1	null	12443(Tax:10090)	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|END_ENTITY	Modulation of cyclin_D1 and its signaling components by the phorbol_ester_TPA and the tyrosine phosphatase inhibitor vanadate .
7153708	0	phorbol_esters	16,30	C3b	41,44	phorbol esters	C3b	MESH:D010703	100862689	Chemical	Gene	stimulate|nsubj|START_ENTITY stimulate|dobj|END_ENTITY	Tumor-promoting phorbol_esters stimulate C3b and C3b ' receptor-mediated phagocytosis in cultured human monocytes .
11012750	0	phorbol_esters	21,35	CD2	73,76	phorbol esters	CD2	MESH:D010703	914	Chemical	Gene	effects|nmod|START_ENTITY receptors|nsubj|effects receptors|dobj|END_ENTITY	Disparate effects of phorbol_esters , CD3 and the costimulatory receptors CD2 and CD28 on RANTES secretion by human T lymphocytes .
7833348	0	phorbol_esters	14,28	GLYT1	57,62	phorbol esters	GLYT1	MESH:D010703	6536	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation by phorbol_esters of the glycine_transporter -LRB- GLYT1 -RRB- in glioblastoma cells .
3967242	0	phorbol_esters	24,38	H2B_and_H4	74,84	phorbol esters	H2B and H4	MESH:D010703	109814(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Specific stimulation by phorbol_esters of the phosphorylation of histones H2B_and_H4 in murine lymphocytes .
11672436	0	phorbol_esters	24,38	IGFBP-1	110,117	phorbol esters	IGFBP-1	MESH:D010703	3484	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Antagonistic effects of phorbol_esters on insulin regulation of insulin-like_growth_factor-binding_protein-1 -LRB- IGFBP-1 -RRB- but not glucose-6-phosphatase gene expression .
1370614	0	phorbol_esters	21,35	IGFBP-1	97,104	phorbol esters	IGFBP-1	MESH:D010703	25685(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Divergent effects of phorbol_esters and insulin on insulin-like growth factor binding protein-1 -LRB- IGFBP-1 -RRB- production and mRNA in rat H4IIE hepatoma cells .
10779634	0	phorbol_esters	60,74	KAI-1	13,18	phorbol esters	KAI-1	MESH:D010703	3732	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|expression expression|compound|END_ENTITY	Induction of KAI-1 expression in metastatic cancer cells by phorbol_esters .
1320249	0	phorbol_esters	92,106	Parathyroid_hormone	0,19	phorbol esters	Parathyroid hormone	MESH:D010703	5741	Chemical	Gene	effect|nmod|START_ENTITY simulation|nmod|effect enhances|parataxis|simulation enhances|nsubj|END_ENTITY	Parathyroid_hormone enhances calcium current in snail neurones -- simulation of the effect by phorbol_esters .
1833206	0	phorbol_esters	86,100	T_cell_antigen_receptor	43,66	phorbol esters	T cell antigen receptor	MESH:D010703	6962	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Differential regulation of gamma and delta T_cell_antigen_receptor gene expression by phorbol_esters and Ca2 + ionophores in the acute_lymphocyte_leukemia DND41 cell line .
7665972	0	phorbol_esters	54,68	cholesteryl_esterase	80,100	phorbol esters	cholesteryl esterase	MESH:D010703	25055(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Effects of insulin , insulin-like growth factor-I , and phorbol_esters on neutral cholesteryl_esterase activity in cultured rat vascular smooth muscle cells .
9545260	0	phorbol_esters	73,87	eIF4E	52,57	phorbol esters	eIF4E	MESH:D010703	1977	Chemical	Gene	response|nmod|START_ENTITY END_ENTITY|nmod|response	The phosphorylation of eukaryotic initiation factor eIF4E in response to phorbol_esters , cell stresses , and cytokines is mediated by distinct MAP kinase pathways .
6149663	0	phorbol_esters	10,24	growth_hormone	43,57	phorbol esters	growth hormone	MESH:D010703	81668(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	Effect of phorbol_esters on the release of growth_hormone and prolactin from rat pituitary cells cultured in monolayer .
7911467	0	phorbol_esters	171,185	intercellular_adhesion_molecule_1	120,153	phorbol esters	intercellular adhesion molecule 1	MESH:D010703	3383	Chemical	Gene	mRNA|nmod|START_ENTITY mRNA|amod|END_ENTITY	Inhibition of protein_kinase_C-alpha expression in human A549 cells by antisense oligonucleotides inhibits induction of intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- mRNA by phorbol_esters .
3113436	0	phorbol_esters	83,97	interleukin_2	52,65	phorbol esters	interleukin 2	MESH:D010703	3558	Chemical	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	The induction of IFN-gamma production and m-RNAs of interleukin_2 and IFN-gamma by phorbol_esters and a calcium ionophore .
7722482	0	phorbol_esters	72,86	interleukin_6	27,40	phorbol esters	interleukin 6	MESH:D010703	24498(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY release|amod|END_ENTITY	Synergistic stimulation of interleukin_6 release and gene expression by phorbol_esters and interleukin_1_beta in rat cortical astrocytes : role of protein kinase C activation and blockade .
3182205	0	phorbol_esters	10,24	lacrimal_gland_protein	32,54	phorbol esters	lacrimal gland protein	MESH:D010703	292801(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of phorbol_esters on rat lacrimal_gland_protein secretion .
2040659	0	phorbol_esters	46,60	ornithine_decarboxylase	14,37	phorbol esters	ornithine decarboxylase	MESH:D010703	24609(Tax:10116)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|mRNA mRNA|amod|END_ENTITY	Regulation of ornithine_decarboxylase mRNA by phorbol_esters and insulin in normal and C-kinase-deficient rat hepatoma cells .
7963658	0	phorbol_esters	85,99	ornithine_decarboxylase	42,65	phorbol esters	ornithine decarboxylase	MESH:D010703	4953	Chemical	Gene	suppression|nmod|START_ENTITY suppression|nmod|expression expression|compound|END_ENTITY	Post-transcriptional suppression of human ornithine_decarboxylase gene expression by phorbol_esters in human keratinocytes .
9368076	0	phorbol_esters	87,101	p21cip1	38,45	phorbol esters	p21cip1	MESH:D010703	1026	Chemical	Gene	effect|nmod|START_ENTITY mediates|dobj|effect mediates|nsubj|END_ENTITY	The cyclin-dependent kinase inhibitor p21cip1 mediates the growth inhibitory effect of phorbol_esters in human venous endothelial cells .
3940894	0	phorbol_esters	48,62	parathyroid_hormone	15,34	phorbol esters	parathyroid hormone	MESH:D010703	280903(Tax:9913)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|amod|END_ENTITY	Stimulation of parathyroid_hormone secretion by phorbol_esters is associated with a decrease of cytosolic calcium .
1650476	0	phorbol_esters	33,47	phosphoenolpyruvate_carboxykinase	68,101	phorbol esters	phosphoenolpyruvate carboxykinase	MESH:D010703	5106	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|transcription transcription|amod|END_ENTITY	Signal transduction convergence : phorbol_esters and insulin inhibit phosphoenolpyruvate_carboxykinase gene transcription through the same 10-base-pair sequence .
10102471	0	phorbol_esters	61,75	plasminogen_activator_inhibitor-1	14,47	phorbol esters	plasminogen activator inhibitor-1	MESH:D010703	5054	Chemical	Gene	synthesis|nmod|START_ENTITY synthesis|amod|END_ENTITY	Activation of plasminogen_activator_inhibitor-1 synthesis by phorbol_esters in human promyelocyte HL-60 -- roles of PCKbeta and MAPK p42 .
1537859	0	phorbol_esters	10,24	protein_kinase_C-zeta	28,49	phorbol esters	protein kinase C-zeta	MESH:D010703	5590	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of phorbol_esters on protein_kinase_C-zeta .
2925687	0	phorbol_esters	83,97	transforming_growth_factor-alpha	13,45	phorbol esters	transforming growth factor-alpha	MESH:D010703	7124	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|expression expression|amod|END_ENTITY	Induction of transforming_growth_factor-alpha expression in human keratinocytes by phorbol_esters .
2824494	0	phorbol_esters	10,24	tumor_necrosis_factor-alpha	93,120	phorbol esters	tumor necrosis factor-alpha	MESH:D010703	7124	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of phorbol_esters on down-regulation and redistribution of cell surface receptors for tumor_necrosis_factor-alpha .
16228063	0	phorbol_myristate_acetate	40,65	CD11b	13,18	phorbol myristate acetate	CD11b	MESH:D013755	3684	Chemical	Gene	down-regulation|nmod|START_ENTITY down-regulation|amod|END_ENTITY	Mechanism of CD11b down-regulation from phorbol_myristate_acetate stimulated polymorphonuclear neutrophils .
4033659	0	phorbol_myristate_acetate	67,92	Collagen	0,8	phorbol myristate acetate	Collagen	MESH:D013755	396340(Tax:9031)	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|expression expression|compound|END_ENTITY	Collagen expression in embryonic chicken chondrocytes treated with phorbol_myristate_acetate .
1723145	0	phorbol_myristate_acetate	40,65	TRH	75,78	phorbol myristate acetate	TRH	MESH:D013755	25569(Tax:10116)	Chemical	Gene	RNA|amod|START_ENTITY RNA|compound|END_ENTITY	Thyrotropin-releasing_hormone -LRB- TRH -RRB- and phorbol_myristate_acetate decrease TRH receptor messenger RNA in rat pituitary GH3 cells : evidence that protein kinase-C mediates the TRH effect .
2201557	0	phorbol_myristate_acetate	10,35	c-myc	39,44	phorbol myristate acetate	c-myc	MESH:D013755	4609	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effect of phorbol_myristate_acetate on c-myc , beta-actin , _ and_FV gene expression in morphologically recognizable human megakaryocytes : a kinetic analysis employing in situ hybridization .
6747295	0	phorbol_myristate_acetate	64,89	catalase	10,18	phorbol myristate acetate	catalase	MESH:D013755	847	Chemical	Gene	Effect|acl|START_ENTITY Effect|nmod|END_ENTITY	Effect of catalase on the proliferation of human lymphocytes to phorbol_myristate_acetate .
1696861	0	phorbol_myristate_acetate	10,35	interleukin-2	64,77	phorbol myristate acetate	interleukin-2	MESH:D013755	3558	Chemical	Gene	_|amod|START_ENTITY _|dep|END_ENTITY	Effect of phorbol_myristate_acetate on T cell colony formation , interleukin-2 -LRB- IL-2 -RRB- _ receptor expression and IL-2 production by cells from patients at all stages of HIV_infection .
2483604	0	phorbol_myristate_acetate	11,36	interleukin-2	40,53	phorbol myristate acetate	interleukin-2	MESH:D013755	3558	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Effects of phorbol_myristate_acetate on interleukin-2 and accompanying interferon production of human leukocytes induced by heat-inactivated Staphylococcus_aureus .
3135944	0	phorbol_myristate_acetate	143,168	interleukin-2	80,93	phorbol myristate acetate	interleukin-2	MESH:D013755	3558	Chemical	Gene	stimulated|nmod|START_ENTITY lymphocytes|acl|stimulated inhibit|nmod|lymphocytes inhibit|dobj|expression expression|nmod|receptors receptors|nmod|END_ENTITY	Antioxidants inhibit proliferation and cell surface expression of receptors for interleukin-2 and transferrin in T lymphocytes stimulated with phorbol_myristate_acetate and ionomycin .
3260781	0	phorbol_myristate_acetate	149,174	interleukin-2	37,50	phorbol myristate acetate	interleukin-2	MESH:D013755	3558	Chemical	Gene	addition|nmod|START_ENTITY correctable|nmod|addition correctable|nsubj|activity activity|compound|END_ENTITY	Deficient phytohemagglutinin-induced interleukin-2 activity in patients with inactive systemic_lupus_erythematosus is correctable by the addition of phorbol_myristate_acetate .
7718953	0	phorbol_myristate_acetate	101,126	interleukin-2	9,22	phorbol myristate acetate	interleukin-2	MESH:D013755	3558	Chemical	Gene	responses|amod|START_ENTITY ionophore|nmod|responses reversed|nmod|ionophore reversed|nsubjpass|production production|compound|END_ENTITY	Impaired interleukin-2 production in active ulcerative_colitis is reversed by calcium ionophore plus phorbol_myristate_acetate and related to altered intracellular Ca2 + responses .
2004606	0	phorbol_myristate_acetate	15,40	parathyroid_hormone	84,103	phorbol myristate acetate	parathyroid hormone	MESH:D013755	280903(Tax:9913)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of phorbol_myristate_acetate on the intracellular degradation of bovine parathyroid_hormone .
2827513	0	phorbol_myristate_acetate	10,35	parathyroid_hormone	52,71	phorbol myristate acetate	parathyroid hormone	MESH:D013755	19226(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of phorbol_myristate_acetate on secretion of parathyroid_hormone .
8315663	0	phorbol_myristate_acetate	24,49	protein_kinase_C	71,87	phorbol myristate acetate	protein kinase C	MESH:D013755	24681(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activity activity|amod|END_ENTITY	Differential effects of phorbol_myristate_acetate and dexamethasone on protein_kinase_C activity and eicosanoids production in cultured rat astrocytes .
6436381	0	phorbol_myristic_acetate	83,107	Leu-1	17,22	phorbol myristic acetate	Leu-1	null	10301	Chemical	Gene	induction|nmod|START_ENTITY induction|nmod|expression expression|compound|END_ENTITY	The induction of Leu-1 antigen expression in human malignant and normal B cells by phorbol_myristic_acetate -LRB- PMA -RRB- .
21941784	0	phosgene	125,133	matrix_metalloproteinase-9	56,82	phosgene	matrix metalloproteinase-9	MESH:D010705	81687(Tax:10116)	Chemical	Gene	-RSB-|amod|START_ENTITY induced|nmod|-RSB- Effects|acl|induced Effects|nmod|END_ENTITY	-LSB- Effects of dexamethasone pretreatment on expression of matrix_metalloproteinase-9 in rats with acute_lung_injury induced by phosgene -RSB- .
9485024	0	phosmidosine	84,96	cyclin_D1	14,23	phosmidosine	cyclin D1	MESH:C068885	595	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|expression expression|amod|END_ENTITY	Inhibition of cyclin_D1 expression and phosphorylation of retinoblastoma protein by phosmidosine , a nucleotide antibiotic .
9952450	0	phosphate	61,70	Apyrase	0,7	phosphate	Apyrase	CHEBI:26020	856722(Tax:4932)	Chemical	Gene	START_ENTITY|nsubj|functions functions|amod|END_ENTITY	Apyrase functions in plant phosphate nutrition and mobilizes phosphate from extracellular ATP .
1302274	0	phosphate	10,19	Ca2	34,37	phosphate	Ca2	CHEBI:26020	54231(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|content content|amod|END_ENTITY	Inorganic phosphate decreases the Ca2 + content of the sarcoplasmic reticulum in saponin-treated rat cardiac trabeculae .
4852567	0	phosphate	34,43	Ca2	59,62	phosphate	Ca2	CHEBI:26020	760	Chemical	Gene	START_ENTITY|nmod|plus plus|amod|END_ENTITY	Ionic and non-ionic mitochondrial phosphate in relation to Ca2 plus and arsenate accumulation .
6160036	0	phosphate	22,31	Ca2	50,53	phosphate	Ca2	CHEBI:26020	54231(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	The role of inorganic phosphate in the release of Ca2 + from rat-liver mitochondria .
6201430	2	phosphate	80,89	Ca2	100,103	phosphate	Ca2	CHEBI:26020	54231(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|+ +|amod|END_ENTITY	Effects of phosphate and pH on Ca2 + - induced Ca2 + release .
6201430	2	phosphate	80,89	Ca2	113,116	phosphate	Ca2	CHEBI:26020	54231(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|dep|END_ENTITY	Effects of phosphate and pH on Ca2 + - induced Ca2 + release .
7516710	5	phosphate	568,577	Ca2	511,514	phosphate	Ca2	CHEBI:26020	760	Chemical	Gene	absence|nmod|START_ENTITY inhibited|nmod|absence inhibited|nsubjpass|+ +|compound|END_ENTITY	Ca2 + uptake was inhibited by Mg2 + only in the absence of phosphate .
8424767	0	phosphate	42,51	Ca2	75,78	phosphate	Ca2	CHEBI:26020	54231(Tax:10116)	Chemical	Gene	concentrations|nmod|START_ENTITY affect|nsubj|concentrations affect|dobj|storage storage|compound|END_ENTITY	Physiological concentrations of inorganic phosphate affect MgATP-dependent Ca2 + storage and inositol_trisphosphate-induced Ca2 + efflux in microsomal vesicles from non-hepatic cells .
8683457	0	phosphate	33,42	Ca2	80,83	phosphate	Ca2	CHEBI:26020	54231(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|+ +|amod|END_ENTITY	Comparative effects of inorganic phosphate and oxalate on uptake and release of Ca2 + by the sarcoplasmic reticulum in saponin skinned rat cardiac trabeculae .
34429	0	phosphate	83,92	D-serine_dehydratase	50,70	phosphate	D-serine dehydratase	CHEBI:26020	63826	Chemical	Gene	study|dep|START_ENTITY study|nmod|END_ENTITY	Phosphorus-31 nuclear magnetic resonance study of D-serine_dehydratase : pryridoxal phosphate binding site .
26303287	0	phosphate	36,45	DMP-1	20,25	phosphate	DMP-1	D010710	13406(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	The in vivo role of DMP-1 and serum phosphate on bone mineral composition .
11072093	0	phosphate	83,92	DNPI	108,112	phosphate	DNPI	CHEBI:26020	84487(Tax:10116)	Chemical	Gene	cotransporter|amod|START_ENTITY cotransporter|appos|END_ENTITY	Regional expression of a gene encoding a neuron-specific Na -LRB- + -RRB- - dependent inorganic phosphate cotransporter -LRB- DNPI -RRB- in the rat forebrain .
11409890	0	phosphate	30,39	FGF-23	0,6	phosphate	FGF-23	CHEBI:26020	8074	Chemical	Gene	transport|compound|START_ENTITY inhibits|dobj|transport inhibits|nsubj|END_ENTITY	FGF-23 inhibits renal tubular phosphate transport and is a PHEX substrate .
16869716	0	phosphate	54,63	FGF-23	36,42	phosphate	FGF-23	CHEBI:26020	8074	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of C-terminal and intact FGF-23 by dietary phosphate in men and women .
11805436	0	phosphate	14,23	FGF23	104,109	phosphate	FGF23	CHEBI:26020	8074	Chemical	Gene	wasting|compound|START_ENTITY Loss|nmod|wasting caused|nsubj|Loss caused|nmod|mutation mutation|compound|END_ENTITY	Loss of renal phosphate wasting in a child with autosomal_dominant_hypophosphatemic_rickets caused by a FGF23 mutation .
14966565	0	phosphate	84,93	FGF23	75,80	phosphate	FGF23	CHEBI:26020	64654(Tax:10090)	Chemical	Gene	metabolism|amod|START_ENTITY END_ENTITY|nmod|metabolism	Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin_D metabolism .
15542045	0	phosphate	41,50	FGF23	20,25	phosphate	FGF23	CHEBI:26020	8074	Chemical	Gene	regulation|nmod|START_ENTITY Bone|dep|regulation Bone|nmod|source source|nmod|END_ENTITY	Bone as a source of FGF23 : regulation by phosphate ?
15885032	0	phosphate	50,59	FGF23	34,39	phosphate	FGF23	CHEBI:26020	64654(Tax:10090)	Chemical	Gene	metabolism|amod|START_ENTITY Role|nmod|metabolism Role|nmod|vitamin_D_receptor vitamin_D_receptor|nmod|action action|compound|END_ENTITY	Role of the vitamin_D_receptor in FGF23 action on phosphate metabolism .
15998839	0	phosphate	59,68	FGF23	31,36	phosphate	FGF23	CHEBI:26020	64654(Tax:10090)	Chemical	Gene	metabolism|amod|START_ENTITY regulating|dobj|metabolism Vitamin_D|advcl|regulating Vitamin_D|dobj|actions actions|compound|END_ENTITY	Vitamin_D receptor-independent FGF23 actions in regulating phosphate and vitamin_D metabolism .
16020653	0	phosphate	144,153	FGF23	42,47	phosphate	FGF23	CHEBI:26020	170583(Tax:10116)	Chemical	Gene	transport|amod|START_ENTITY controls|dobj|transport link|acl:relcl|controls expression|dep|link expression|compound|END_ENTITY	1alpha,25-Dihydroxyvitamin _ D3 upregulates FGF23 gene expression in bone : the final link in a renal-gastrointestinal-skeletal_axis that controls phosphate transport .
16292192	0	phosphate	35,44	FGF23	1,6	phosphate	FGF23	CHEBI:26020	8074	Chemical	Gene	homeostasis|amod|START_ENTITY regulating|dobj|homeostasis hormone|acl|regulating END_ENTITY|appos|hormone	-LSB- FGF23 , a `` new '' hormone regulating phosphate homeostasis and vitamin_D metabolism -RSB- .
16337659	0	phosphate	45,54	FGF23	14,19	phosphate	FGF23	CHEBI:26020	8074	Chemical	Gene	level|compound|START_ENTITY correlated|nmod|level correlated|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of FGF23 is correlated with serum phosphate level in isolated fibrous_dysplasia .
17276744	0	phosphate	30,39	FGF23	0,5	phosphate	FGF23	CHEBI:26020	8074	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|nsubj|END_ENTITY	FGF23 is a hormone-regulating phosphate metabolism -- unique biological characteristics of FGF23 .
17276744	0	phosphate	30,39	FGF23	89,94	phosphate	FGF23	CHEBI:26020	8074	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|dep|characteristics characteristics|nmod|END_ENTITY	FGF23 is a hormone-regulating phosphate metabolism -- unique biological characteristics of FGF23 .
17293108	0	phosphate	170,179	FGF23	51,56	phosphate	FGF23	CHEBI:26020	8074	Chemical	Gene	metabolism|compound|START_ENTITY regulation|nmod|metabolism orchestrate|dobj|regulation genes|acl:relcl|orchestrate _|nsubj|genes _|dobj|induction induction|nmod|END_ENTITY	1,25-Dihydroxyvitamin _ D3/VDR-mediated induction of FGF23 as well as transcriptional control of other bone anabolic and catabolic genes that orchestrate the regulation of phosphate and calcium mineral metabolism .
17464094	0	phosphate	111,120	FGF23	29,34	phosphate	FGF23	CHEBI:26020	8074	Chemical	Gene	regulation|compound|START_ENTITY role|nmod|regulation Fibroblast_growth_factor-23|dep|role Fibroblast_growth_factor-23|appos|END_ENTITY	Fibroblast_growth_factor-23 -LRB- FGF23 -RRB- in patients with transient_hypoparathyroidism : its important role in serum phosphate regulation .
19449283	0	phosphate	5,14	FGF23	79,84	phosphate	FGF23	CHEBI:26020	8074	Chemical	Gene	supplementation|compound|START_ENTITY corrects|nsubj|supplementation corrects|dobj|END_ENTITY	Oral phosphate supplementation corrects hypophosphatemia and normalizes plasma FGF23 and 25-hydroxyvitamin_D3 levels in women with chronic metabolic_acidosis .
19483273	1	phosphate	134,143	FGF23	61,66	phosphate	FGF23	CHEBI:26020	64654(Tax:10090)	Chemical	Gene	-RSB-|amod|START_ENTITY regulation|nmod|-RSB- action|nmod|regulation END_ENTITY|dep|action	FGF23 ; physiological action and molecular mechanism in the regulation of phosphate and vitamin_D metabolism -RSB- .
19669798	0	phosphate	104,113	FGF23	66,71	phosphate	FGF23	CHEBI:26020	8074	Chemical	Gene	metabolism|amod|START_ENTITY disorders|nmod|metabolism implications|nmod|disorders Regulation|dep|implications Regulation|nmod|transport transport|nmod|fibroblast_growth_factor_23 fibroblast_growth_factor_23|appos|END_ENTITY	Regulation of phosphate transport by fibroblast_growth_factor_23 -LRB- FGF23 -RRB- : implications for disorders of phosphate metabolism .
19669798	0	phosphate	14,23	FGF23	66,71	phosphate	FGF23	CHEBI:26020	8074	Chemical	Gene	transport|amod|START_ENTITY transport|nmod|fibroblast_growth_factor_23 fibroblast_growth_factor_23|appos|END_ENTITY	Regulation of phosphate transport by fibroblast_growth_factor_23 -LRB- FGF23 -RRB- : implications for disorders of phosphate metabolism .
20844473	0	phosphate	68,77	FGF23	40,45	phosphate	FGF23	CHEBI:26020	170583(Tax:10116)	Chemical	Gene	handling|compound|START_ENTITY evidence|nmod|handling evidence|nmod|role role|nmod|END_ENTITY	Direct evidence for a causative role of FGF23 in the abnormal renal phosphate handling and vitamin_D metabolism in rats with early-stage chronic_kidney_disease .
22419710	0	phosphate	72,81	FGF23	36,41	phosphate	FGF23	CHEBI:26020	8074	Chemical	Gene	leak|compound|START_ENTITY associated|nmod|leak associated|nsubjpass|variant variant|nmod|gene gene|compound|END_ENTITY	A functional allelic variant of the FGF23 gene is associated with renal phosphate leak in calcium nephrolithiasis .
23129509	1	phosphate	238,247	FGF23	162,167	phosphate	FGF23	CHEBI:26020	64654(Tax:10090)	Chemical	Gene	homeostasis|amod|START_ENTITY essential|nmod|homeostasis osteocytes|acl:relcl|essential secreted|nmod|osteocytes factor|acl|secreted factor|nsubj|Fibroblast_growth_factor_23 Fibroblast_growth_factor_23|appos|END_ENTITY	Fibroblast_growth_factor_23 -LRB- FGF23 -RRB- is a circulating factor secreted by osteocytes that is essential for phosphate homeostasis .
23391319	0	phosphate	14,23	FGF23	68,73	phosphate	FGF23	CHEBI:26020	8074	Chemical	Gene	binders|amod|START_ENTITY effect|nmod|binders effect|nmod|levels levels|nummod|END_ENTITY	The effect of phosphate binders , calcium and lanthanum_carbonate on FGF23 levels in chronic_kidney_disease patients .
23471131	0	phosphate	19,28	FGF23	66,71	phosphate	FGF23	CHEBI:26020	8074	Chemical	Gene	restriction|amod|START_ENTITY Effects|nmod|restriction binders|nsubj|Effects binders|nmod|levels levels|nummod|END_ENTITY	Effects of dietary phosphate restriction and phosphate binders on FGF23 levels in CKD .
23698235	2	phosphate	352,361	FGF23	440,445	phosphate	FGF23	CHEBI:26020	64654(Tax:10090)	Chemical	Gene	retention|amod|START_ENTITY responsible|nsubj|retention responsible|nmod|elevation elevation|nmod|END_ENTITY	Here , we tested whether phosphate retention in chronic_kidney_disease -LRB- CKD -RRB- is responsible for the elevation of FGF23 in serum using Col4a3 knockout mice , a murine model of Alport_disease exhibiting CKD .
23708836	0	phosphate	4,13	FGF23	144,149	phosphate	FGF23	CHEBI:26020	64654(Tax:10090)	Chemical	Gene	NaPi-IIa|amod|START_ENTITY determines|nsubj|NaPi-IIa determines|advcl|dietary dietary|nmod|irrespective irrespective|nmod|levels levels|compound|END_ENTITY	The phosphate transporter NaPi-IIa determines the rapid renal adaptation to dietary phosphate intake in mouse irrespective of persistently high FGF23 levels .
23708836	0	phosphate	84,93	FGF23	144,149	phosphate	FGF23	CHEBI:26020	64654(Tax:10090)	Chemical	Gene	intake|amod|START_ENTITY dietary|dobj|intake dietary|nmod|irrespective irrespective|nmod|levels levels|compound|END_ENTITY	The phosphate transporter NaPi-IIa determines the rapid renal adaptation to dietary phosphate intake in mouse irrespective of persistently high FGF23 levels .
23873717	0	phosphate	41,50	FGF23	75,80	phosphate	FGF23	CHEBI:26020	64654(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY causes|dobj|metabolism causes|advcl|elevating elevating|dobj|END_ENTITY	Neonatal iron_deficiency causes abnormal phosphate metabolism by elevating FGF23 in normal and ADHR mice .
24080872	0	phosphate	8,17	FGF23	59,64	phosphate	FGF23	CHEBI:26020	8074	Chemical	Gene	START_ENTITY|dep|challenges challenges|acl|exploring exploring|nmod|regulation regulation|compound|END_ENTITY	Dietary phosphate : the challenges of exploring its role in FGF23 regulation .
24259513	0	phosphate	20,29	FGF23	43,48	phosphate	FGF23	CHEBI:26020	64654(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY transport|nmod|END_ENTITY	Regulation of renal phosphate transport by FGF23 is mediated by FGFR1 and FGFR4 .
25427080	0	phosphate	43,52	FGF23	26,31	phosphate	FGF23	CHEBI:26020	8074	Chemical	Gene	regulation|amod|START_ENTITY interactions|nmod|regulation interactions|nmod|END_ENTITY	Molecular interactions of FGF23 and PTH in phosphate regulation .
25515813	0	phosphate	90,99	FGF23	81,86	phosphate	FGF23	CHEBI:26020	8074	Chemical	Gene	uptake|amod|START_ENTITY antagonizing|nmod|uptake antagonizing|dobj|effect effect|nmod|END_ENTITY	Selection of a novel FGF23-binding peptide antagonizing the inhibitory effect of FGF23 on phosphate uptake .
25700931	0	phosphate	21,30	FGF23	60,65	phosphate	FGF23	D010710	8074	Chemical	Gene	Impact|nmod|START_ENTITY excretion|nsubj|Impact excretion|nmod|relation relation|nmod|END_ENTITY	Impact of fractional phosphate excretion on the relation of FGF23 with outcome in CKD patients .
14966565	0	phosphate	84,93	Fgf23	21,26	phosphate	Fgf23	CHEBI:26020	64654(Tax:10090)	Chemical	Gene	metabolism|amod|START_ENTITY FGF23|nmod|metabolism role|nmod|FGF23 demonstrates|dobj|role demonstrates|nsubj|ablation ablation|nmod|END_ENTITY	Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin_D metabolism .
15869926	0	phosphate	22,31	Fgf23	82,87	phosphate	Fgf23	CHEBI:26020	64654(Tax:10090)	Chemical	Gene	regulation|amod|START_ENTITY regulation|acl|circulating circulating|dobj|concentrations concentrations|amod|END_ENTITY	Genetic dissection of phosphate - and vitamin_D-mediated regulation of circulating Fgf23 concentrations .
18835926	0	phosphate	116,125	Fgf23	76,81	phosphate	Fgf23	CHEBI:26020	64654(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY regulation|nmod|homeostasis mediated|dobj|regulation mediated|nsubj|evidence evidence|appos|fibroblast_growth_factor_23 fibroblast_growth_factor_23|appos|END_ENTITY	In vivo genetic evidence for klotho-dependent , fibroblast_growth_factor_23 -LRB- Fgf23 -RRB- - mediated regulation of systemic phosphate homeostasis .
15827108	0	phosphate	127,136	Fibroblast_growth_factor-23	0,27	phosphate	Fibroblast growth factor-23	CHEBI:26020	8074	Chemical	Gene	regulation|compound|START_ENTITY role|nmod|regulation END_ENTITY|dep|role	Fibroblast_growth_factor-23 in patients with Graves ' _ disease before and after antithyroid therapy : its important role in serum phosphate regulation .
17464094	0	phosphate	111,120	Fibroblast_growth_factor-23	0,27	phosphate	Fibroblast growth factor-23	CHEBI:26020	8074	Chemical	Gene	regulation|compound|START_ENTITY role|nmod|regulation END_ENTITY|dep|role	Fibroblast_growth_factor-23 -LRB- FGF23 -RRB- in patients with transient_hypoparathyroidism : its important role in serum phosphate regulation .
20012018	0	phosphate	73,82	Fibroblast_growth_factor-23	0,27	phosphate	Fibroblast growth factor-23	CHEBI:26020	8074	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	Fibroblast_growth_factor-23 is associated with C-reactive_protein , serum phosphate and bone_mineral_density in chronic_kidney_disease .
14505231	0	phosphate	46,55	G6PD	71,75	phosphate	G6PD	CHEBI:26020	2539	Chemical	Gene	START_ENTITY|acl|-RSB- -RSB-|dobj|variants variants|appos|END_ENTITY	Five different glucose-6-phophate -LSB- correction phosphate -RSB- dehydrogenase -LRB- G6PD -RRB- variants found among 11 G6PD-deficient persons in Flores Island , Indonesia .
8786155	0	phosphate	20,29	G6PD	45,49	phosphate	G6PD	CHEBI:26020	2539	Chemical	Gene	dehydrogenase|compound|START_ENTITY dehydrogenase|appos|END_ENTITY	Leukocyte glucose 6 phosphate dehydrogenase -LRB- G6PD -RRB- as prognostic indicator in children with acute_lymphocytic_leukemia .
18976705	0	phosphate	126,135	GALNT3	0,6	phosphate	GALNT3	CHEBI:26020	2591	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	GALNT3 , a gene associated with hyperphosphatemic_familial_tumoral_calcinosis , is transcriptionally regulated by extracellular phosphate and modulates matrix metalloproteinase activity .
7417521	0	phosphate	61,70	Glutathione_reductase	0,21	phosphate	Glutathione reductase	CHEBI:26020	2936	Chemical	Gene	START_ENTITY|nsubj|activity activity|amod|END_ENTITY	Glutathione_reductase activity and pyridoxine -LRB- pyridoxamine -RRB- phosphate oxidase activity in the red cell .
10830313	0	phosphate	53,62	Glvr-1	126,132	phosphate	Glvr-1	CHEBI:26020	20515(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY transport|nmod|END_ENTITY	Transforming growth factor-beta stimulates inorganic phosphate transport and expression of the type III phosphate transporter Glvr-1 in chondrogenic ATDC5 cells .
9556059	0	phosphate	5,14	Glvr-1	81,87	phosphate	Glvr-1	CHEBI:26020	20515(Tax:10090)	Chemical	Gene	cotransport|amod|START_ENTITY +|dep|cotransport +|dep|evidence evidence|nmod|expression expression|amod|END_ENTITY	Na + - phosphate cotransport in mouse distal convoluted tubule cells : evidence for Glvr-1 and Ram-1 gene expression .
9889306	0	phosphate	37,46	Glvr-1	30,36	phosphate	Glvr-1	CHEBI:26020	6574	Chemical	Gene	START_ENTITY|nsubj|Characterization Characterization|nmod|END_ENTITY	Characterization of the human Glvr-1 phosphate transporter/retrovirus receptor gene and promoter region .
16595195	0	phosphate	99,108	HPBP	126,130	phosphate	HPBP	CHEBI:26020	100144632	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Tandem purification of two HDL-associated partner proteins in human plasma , paraoxonase -LRB- PON1 -RRB- and phosphate binding protein -LRB- HPBP -RRB- using hydroxyapatite chromatography .
17139481	3	phosphate	539,548	HPr	558,561	phosphate	HPr	CHEBI:26020	3250	Chemical	Gene	group|amod|START_ENTITY group|nmod|END_ENTITY	The calculated pK -LRB- a -RRB- values for a representative set of HPr -LRB- Ser46P -RRB- structures indicate that the phosphate group of HPr -LRB- Ser46P -RRB- exists predominantly in the unprotonated form under neutral conditions .
2193542	0	phosphate	19,28	Insulin	0,7	phosphate	Insulin	CHEBI:26020	3630	Chemical	Gene	transport|amod|START_ENTITY stimulates|dobj|transport stimulates|nsubj|END_ENTITY	Insulin stimulates phosphate transport in opossum kidney epithelial cells .
12151082	0	phosphate	122,131	Matrix_Gla_protein	0,18	phosphate	Matrix Gla protein	CHEBI:26020	4256	Chemical	Gene	affinity|compound|START_ENTITY affinity|nmod|affinity enhances|dobj|affinity dependent|parataxis|enhances dependent|nsubj|END_ENTITY	Matrix_Gla_protein binding to hydroxyapatite is dependent on the ionic environment : calcium enhances binding affinity but phosphate and magnesium decrease affinity .
19005008	0	phosphate	50,59	Matrix_extracellular_phosphoglycoprotein	0,40	phosphate	Matrix extracellular phosphoglycoprotein	CHEBI:26020	56955	Chemical	Gene	transport|amod|START_ENTITY inhibits|dobj|transport inhibits|nsubj|END_ENTITY	Matrix_extracellular_phosphoglycoprotein inhibits phosphate transport .
11886840	0	phosphate	84,93	N-acetylneuraminic_acid	51,74	phosphate	N-acetylneuraminic acid	CHEBI:26020	41528(Tax:7227)	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Expression of a functional Drosophila_melanogaster N-acetylneuraminic_acid -LRB- Neu5Ac -RRB- phosphate synthase gene : evidence for endogenous sialic_acid biosynthetic ability in insects .
20145188	0	phosphate	9,18	N-ras	29,34	phosphate	N-ras	CHEBI:26020	18176(Tax:10090)	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Elevated phosphate activates N-ras and promotes cell transformation and skin tumorigenesis .
1915351	0	phosphate	39,48	NBL-1	100,105	phosphate	NBL-1	CHEBI:26020	535280(Tax:9913)	Chemical	Gene	transport|amod|START_ENTITY transport|nmod|END_ENTITY	Adaptive regulation of Na -LRB- + -RRB- - dependent phosphate transport in the bovine renal epithelial cell line NBL-1 .
22904329	0	phosphate	72,81	NHE3_regulatory_factor_1	0,24	phosphate	NHE3 regulatory factor 1	CHEBI:26020	59114(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	NHE3_regulatory_factor_1 -LRB- NHERF1 -RRB- modulates intestinal sodium-dependent phosphate transporter -LRB- NaPi-2b -RRB- expression in apical microvilli .
15942053	0	phosphate	45,54	NHERF-1	68,75	phosphate	NHERF-1	CHEBI:26020	26941(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY transport|nmod|END_ENTITY	Defective PTH regulation of sodium-dependent phosphate transport in NHERF-1 - / - renal proximal tubule cells and wild-type cells adapted to low-phosphate media .
16249272	0	phosphate	43,52	NHERF-1	87,94	phosphate	NHERF-1	CHEBI:26020	26941(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|compound|END_ENTITY	Longitudinal study of urinary excretion of phosphate , calcium , and uric_acid in mutant NHERF-1 null mice .
11473618	0	phosphate	55,64	NPT2	34,38	phosphate	NPT2	CHEBI:26020	20505(Tax:10090)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|gene gene|compound|END_ENTITY	Transcriptional regulation of the NPT2 gene by dietary phosphate .
24194864	0	phosphate	34,43	NPT2b	63,68	phosphate	NPT2b	CHEBI:26020	20531(Tax:10090)	Chemical	Gene	2b|amod|START_ENTITY 2b|appos|END_ENTITY	Knockdown of the sodium-dependent phosphate co-transporter 2b -LRB- NPT2b -RRB- suppresses lung tumorigenesis .
15505377	0	phosphate	23,32	NPT4	0,4	phosphate	NPT4	CHEBI:26020	10786	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|appos|transporter	NPT4 , a new microsomal phosphate transporter : mutation analysis in glycogen_storage_disease_type_Ic .
22904329	0	phosphate	72,81	NaPi-2b	95,102	phosphate	NaPi-2b	CHEBI:26020	84395(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	NHE3_regulatory_factor_1 -LRB- NHERF1 -RRB- modulates intestinal sodium-dependent phosphate transporter -LRB- NaPi-2b -RRB- expression in apical microvilli .
16705152	0	phosphate	116,125	Npt2a	92,97	phosphate	Npt2a	CHEBI:26020	20505(Tax:10090)	Chemical	Gene	media|compound|START_ENTITY restores|nmod|media restores|dobj|regulation regulation|amod|END_ENTITY	Adenoviral expression of NHERF-1 in NHERF-1 null mouse renal proximal tubule cells restores Npt2a regulation by low phosphate media and parathyroid_hormone .
19570882	0	phosphate	73,82	Npt2a	0,5	phosphate	Npt2a	CHEBI:26020	20505(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY roles|nmod|metabolism play|dobj|roles play|nsubj|END_ENTITY	Npt2a and Npt2c in mice play distinct and synergistic roles in inorganic phosphate metabolism and skeletal development .
20088828	0	phosphate	120,129	Npt2a	146,151	phosphate	Npt2a	CHEBI:26020	20505(Tax:10090)	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Thyroid hormones regulate phosphate homoeostasis through transcriptional control of the renal type IIa sodium-dependent phosphate co-transporter -LRB- Npt2a -RRB- gene .
20088828	0	phosphate	26,35	Npt2a	146,151	phosphate	Npt2a	CHEBI:26020	20505(Tax:10090)	Chemical	Gene	homoeostasis|amod|START_ENTITY regulate|dobj|homoeostasis regulate|nmod|control control|nmod|gene gene|appos|END_ENTITY	Thyroid hormones regulate phosphate homoeostasis through transcriptional control of the renal type IIa sodium-dependent phosphate co-transporter -LRB- Npt2a -RRB- gene .
24190035	0	phosphate	87,96	Npt2a	113,118	phosphate	Npt2a	CHEBI:26020	20505(Tax:10090)	Chemical	Gene	co-transporter|compound|START_ENTITY co-transporter|appos|END_ENTITY	Hypercholesterolemia and effects of high cholesterol diet in type IIa sodium-dependent phosphate co-transporter -LRB- Npt2a -RRB- deficient mice .
19729436	7	phosphate	1170,1179	Npt2b	1269,1274	phosphate	Npt2b	CHEBI:26020	20531(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY analysis|nmod|transport demonstrated|nmod|analysis demonstrated|ccomp|contributes contributes|nsubj|END_ENTITY	In vitro analysis of active phosphate transport in ileum segments isolated from wild-type or Npt2b -LRB- - / - -RRB- mice demonstrated that Npt2b contributes to > 90 % of total active phosphate absorption .
19729436	7	phosphate	1311,1320	Npt2b	1269,1274	phosphate	Npt2b	CHEBI:26020	20531(Tax:10090)	Chemical	Gene	absorption|compound|START_ENTITY %|nmod|absorption >|dobj|% contributes|xcomp|> contributes|nsubj|END_ENTITY	In vitro analysis of active phosphate transport in ileum segments isolated from wild-type or Npt2b -LRB- - / - -RRB- mice demonstrated that Npt2b contributes to > 90 % of total active phosphate absorption .
21816756	0	phosphate	10,19	Npt2b	76,81	phosphate	Npt2b	CHEBI:26020	20531(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY homeostasis|nmod|END_ENTITY	Inorganic phosphate homeostasis in sodium-dependent phosphate cotransporter Npt2b / mice .
12920127	0	phosphate	36,45	Osteopontin	0,11	phosphate	Osteopontin	CHEBI:26020	6696	Chemical	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	Osteopontin regulation by inorganic phosphate is ERK1/2 - , protein kinase C - , and proteasome-dependent .
16513836	0	phosphate	39,48	Osteopontin	0,11	phosphate	Osteopontin	CHEBI:26020	20750(Tax:10090)	Chemical	Gene	bone_loss|amod|START_ENTITY suppresses|dobj|bone_loss suppresses|nsubj|deficiency deficiency|compound|END_ENTITY	Osteopontin deficiency suppresses high phosphate load-induced bone_loss via specific modulation of osteoclasts .
12923174	0	phosphate	43,52	PHO84	76,81	phosphate	PHO84	CHEBI:26020	854916(Tax:4932)	Chemical	Gene	transporter|compound|START_ENTITY encoded|nsubj|transporter encoded|nmod|functions functions|compound|END_ENTITY	The Saccharomyces_cerevisiae high affinity phosphate transporter encoded by PHO84 also functions in manganese homeostasis .
2038328	0	phosphate	64,73	PHO84	4,9	phosphate	PHO84	CHEBI:26020	854916(Tax:4932)	Chemical	Gene	transporter|compound|START_ENTITY encodes|dobj|transporter encodes|nsubj|gene gene|compound|END_ENTITY	The PHO84 gene of Saccharomyces_cerevisiae encodes an inorganic phosphate transporter .
23509734	0	phosphate	10,19	PIST	124,128	phosphate	PIST	CHEBI:26020	57120	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	Inorganic phosphate modulates the expression of the NaPi-2a transporter in the trans-Golgi_network and the interaction with PIST in the proximal tubule .
10196273	0	phosphate	14,23	PIT-2	113,118	phosphate	PIT-2	CHEBI:26020	20516(Tax:10090)	Chemical	Gene	entry|amod|START_ENTITY Modulation|nmod|entry Modulation|nmod|END_ENTITY	Modulation of phosphate uptake and amphotropic murine leukemia virus entry by posttranslational modifications of PIT-2 .
11322772	0	phosphate	70,79	PP7	63,66	phosphate	PP7	CHEBI:26020	836507(Tax:3702)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Noncompetitive inhibition of plant protein Ser/Thr phosphatase PP7 by phosphate .
15942053	0	phosphate	45,54	PTH	10,13	phosphate	PTH	CHEBI:26020	19226(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY regulation|nmod|transport regulation|compound|END_ENTITY	Defective PTH regulation of sodium-dependent phosphate transport in NHERF-1 - / - renal proximal tubule cells and wild-type cells adapted to low-phosphate media .
20059333	0	phosphate	14,23	PTH	39,42	phosphate	PTH	CHEBI:26020	5741	Chemical	Gene	Regulation|nmod|START_ENTITY homeostasis|nsubj|Regulation homeostasis|nmod|END_ENTITY	Regulation of phosphate homeostasis by PTH , vitamin_D , and FGF23 .
1166316	0	phosphate	93,102	Parathyroid_hormone	0,19	phosphate	Parathyroid hormone	CHEBI:26020	24694(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY effects|nmod|transport vitamin_D3|dep|effects vitamin_D3|amod|END_ENTITY	Parathyroid_hormone and 25-hydroxy vitamin_D3 : synergistic and antagonistic effects on renal phosphate transport .
12003377	0	phosphate	67,76	Parathyroid_hormone	0,19	phosphate	Parathyroid hormone	CHEBI:26020	5741	Chemical	Gene	role|nmod|START_ENTITY suppression|dep|role suppression|amod|END_ENTITY	Parathyroid_hormone suppression by intravenous calcitriol : role of phosphate , calcium , race and diabetes .
17975671	0	phosphate	35,44	Parathyroid_hormone	0,19	phosphate	Parathyroid hormone	CHEBI:26020	19226(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY inhibits|dobj|transport inhibits|nsubj|END_ENTITY	Parathyroid_hormone inhibits renal phosphate transport by phosphorylation of serine 77 of sodium-hydrogen_exchanger_regulatory_factor-1 .
2159721	0	phosphate	30,39	Parathyroid_hormone	0,19	phosphate	Parathyroid hormone	CHEBI:26020	5741	Chemical	Gene	transport|amod|START_ENTITY action|nmod|transport action|amod|END_ENTITY	Parathyroid_hormone action on phosphate transport is inhibited by high osmolality .
23722911	1	phosphate	47,56	Parathyroid_hormone	12,31	phosphate	Parathyroid hormone	CHEBI:26020	5741	Chemical	Gene	transport|compound|START_ENTITY inhibits|dobj|transport inhibits|nsubj|END_ENTITY	Parathyroid_hormone inhibits renal phosphate transport by phosphorylation of serine 77 of sodium-hydrogen exchanger regulatory factor-1 .
2422014	0	phosphate	31,40	Parathyroid_hormone	0,19	phosphate	Parathyroid hormone	CHEBI:26020	24694(Tax:10116)	Chemical	Gene	efflux|amod|START_ENTITY stimulates|dobj|efflux stimulates|nsubj|END_ENTITY	Parathyroid_hormone stimulates phosphate efflux through an apparently adenosine_3 ' ,5 ' - monophosphate-independent process in rat parotid cell aggregates .
2465766	0	phosphate	38,47	Parathyroid_hormone	0,19	phosphate	Parathyroid hormone	CHEBI:26020	5741	Chemical	Gene	cotransport|amod|START_ENTITY inhibition|dep|cotransport inhibition|amod|END_ENTITY	Parathyroid_hormone inhibition of Na + / phosphate cotransport in OK cells : generation of second messengers in the regulatory cascade .
2548612	0	phosphate	38,47	Parathyroid_hormone	0,19	phosphate	Parathyroid hormone	CHEBI:26020	5741	Chemical	Gene	cotransport|amod|START_ENTITY inhibition|dep|cotransport inhibition|amod|END_ENTITY	Parathyroid_hormone inhibition of Na + / phosphate cotransport in OK cells : requirement of protein kinase C-dependent pathway .
2548613	0	phosphate	38,47	Parathyroid_hormone	0,19	phosphate	Parathyroid hormone	CHEBI:26020	5741	Chemical	Gene	cotransport|amod|START_ENTITY inhibition|dep|cotransport inhibition|amod|END_ENTITY	Parathyroid_hormone inhibition of Na + / phosphate cotransport in OK cells : intracellular -LSB- Ca2 + -RSB- as a second messenger .
3014885	0	phosphate	29,38	Parathyroid_hormone	0,19	phosphate	Parathyroid hormone	CHEBI:26020	399502(Tax:9823)	Chemical	Gene	transport|amod|START_ENTITY inhibits|dobj|transport inhibits|nsubj|END_ENTITY	Parathyroid_hormone inhibits phosphate transport in OK cells but not in LLC-PK1 and JTC-12 .
3495458	0	phosphate	30,39	Parathyroid_hormone	0,19	phosphate	Parathyroid hormone	CHEBI:26020	5741	Chemical	Gene	transport|amod|START_ENTITY regulates|dobj|transport regulates|nsubj|END_ENTITY	Parathyroid_hormone regulates phosphate transport in OK cells via an irreversible inactivation of a membrane protein .
6465346	0	phosphate	66,75	Parathyroid_hormone	0,19	phosphate	Parathyroid hormone	CHEBI:26020	396436(Tax:9031)	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|nmod|transport	Parathyroid_hormone effect on chicken renal brush-border membrane phosphate transport .
7272293	0	phosphate	34,43	Parathyroid_hormone	0,19	phosphate	Parathyroid hormone	CHEBI:26020	403986(Tax:9615)	Chemical	Gene	transport|amod|START_ENTITY inhibition|nmod|transport inhibition|amod|END_ENTITY	Parathyroid_hormone inhibition of phosphate transport in renal brush border vesicles from phosphate-depleted dogs .
7733336	0	phosphate	30,39	Parathyroid_hormone	0,19	phosphate	Parathyroid hormone	CHEBI:26020	24694(Tax:10116)	Chemical	Gene	mRNA|amod|START_ENTITY action|nmod|mRNA action|amod|END_ENTITY	Parathyroid_hormone action on phosphate transporter mRNA and protein in rat renal proximal tubules .
8756542	0	phosphate	39,48	Parathyroid_hormone	0,19	phosphate	Parathyroid hormone	CHEBI:26020	280903(Tax:9913)	Chemical	Gene	transport|amod|START_ENTITY stimulates|dobj|transport stimulates|nsubj|END_ENTITY	Parathyroid_hormone rapidly stimulates phosphate transport in perfused duodenal loops of chicks : lack of modulation by vitamin_D metabolites .
984201	0	phosphate	43,52	Parathyroid_hormone	0,19	phosphate	Parathyroid hormone	CHEBI:26020	5741	Chemical	Gene	excretion|nmod|START_ENTITY excretion|amod|END_ENTITY	Parathyroid_hormone and renal excretion of phosphate and calcium in normal starlings .
1581066	0	phosphate	54,63	Parathyroid_hormone-related_peptide	0,35	phosphate	Parathyroid hormone-related peptide	CHEBI:26020	443135(Tax:9940)	Chemical	Gene	START_ENTITY|nsubj|increases increases|amod|END_ENTITY	Parathyroid_hormone-related_peptide increases urinary phosphate excretion in fetal lambs .
22006791	0	phosphate	70,79	Phex	2,6	phosphate	Phex	CHEBI:26020	18675(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|mutation mutation|compound|END_ENTITY	A Phex mutation in a murine model of X-linked_hypophosphatemia alters phosphate responsiveness of bone cells .
10518922	0	phosphate	70,79	Pho84	64,69	phosphate	Pho84	CHEBI:26020	854916(Tax:4932)	Chemical	Gene	permease|compound|START_ENTITY permease|amod|END_ENTITY	Characterization of purified and unidirectionally reconstituted Pho84 phosphate permease of Saccharomyces_cerevisiae .
10580087	0	phosphate	79,88	Pho84	73,78	phosphate	Pho84	CHEBI:26020	854916(Tax:4932)	Chemical	Gene	START_ENTITY|nsubj|localization localization|nmod|END_ENTITY	Intracellular localization of an active green fluorescent protein-tagged Pho84 phosphate permease in Saccharomyces_cerevisiae .
11573939	0	phosphate	38,47	Pho84	32,37	phosphate	Pho84	CHEBI:26020	854916(Tax:4932)	Chemical	Gene	START_ENTITY|nsubj|Properties Properties|nmod|END_ENTITY	Properties of the cysteine-less Pho84 phosphate transporter of Saccharomyces_cerevisiae .
12208499	0	phosphate	86,95	Pho84	80,85	phosphate	Pho84	CHEBI:26020	854916(Tax:4932)	Chemical	Gene	START_ENTITY|nsubj|analysis analysis|nmod|C-terminus C-terminus|nmod|END_ENTITY	Mutagenic and functional analysis of the C-terminus of Saccharomyces_cerevisiae Pho84 phosphate transporter .
15533049	0	phosphate	32,41	Pho84	129,134	phosphate	Pho84	CHEBI:26020	854916(Tax:4932)	Chemical	Gene	analogue|amod|START_ENTITY Effects|appos|analogue Effects|nmod|expression expression|nmod|END_ENTITY	Effects of methylphosphonate , a phosphate analogue , on the expression and degradation of the high-affinity phosphate transporter Pho84 , in Saccharomyces_cerevisiae .
15589830	0	phosphate	52,61	Pho84	46,51	phosphate	Pho84	CHEBI:26020	854916(Tax:4932)	Chemical	Gene	START_ENTITY|nsubj|modeling modeling|nmod|END_ENTITY	Structural modeling of dual-affinity purified Pho84 phosphate transporter .
1620108	0	phosphate	88,97	Pho84	72,77	phosphate	Pho84	CHEBI:26020	854916(Tax:4932)	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	Putative GTP-binding protein , Gtr1 , associated with the function of the Pho84 inorganic phosphate transporter in Saccharomyces_cerevisiae .
19348508	0	phosphate	85,94	Pho84	79,84	phosphate	Pho84	CHEBI:26020	854916(Tax:4932)	Chemical	Gene	START_ENTITY|nsubj|mechanisms mechanisms|acl|controlling controlling|dobj|downregulation downregulation|nmod|END_ENTITY	Molecular mechanisms controlling phosphate-induced downregulation of the yeast Pho84 phosphate transporter .
20133652	0	phosphate	78,87	Pho84	72,77	phosphate	Pho84	CHEBI:26020	854916(Tax:4932)	Chemical	Gene	START_ENTITY|csubj|Transport Transport|nmod|site site|nmod|END_ENTITY	Transport and signaling through the phosphate-binding site of the yeast Pho84 phosphate transceptor .
21782409	0	phosphate	112,121	Pho84	87,92	phosphate	Pho84	CHEBI:26020	854916(Tax:4932)	Chemical	Gene	ions|amod|START_ENTITY sensing|nmod|ions symporter_membrane_protein|nmod|sensing symporter_membrane_protein|appos|END_ENTITY	A membrane protein based biosensor : use of a phosphate -- H + _ symporter_membrane_protein -LRB- Pho84 -RRB- in the sensing of phosphate ions .
21782409	0	phosphate	45,54	Pho84	87,92	phosphate	Pho84	CHEBI:26020	854916(Tax:4932)	Chemical	Gene	use|nmod|START_ENTITY protein|dep|use protein|dep|symporter_membrane_protein symporter_membrane_protein|appos|END_ENTITY	A membrane protein based biosensor : use of a phosphate -- H + _ symporter_membrane_protein -LRB- Pho84 -RRB- in the sensing of phosphate ions .
22587366	0	phosphate	32,41	Pho84	100,105	phosphate	Pho84	CHEBI:26020	854916(Tax:4932)	Chemical	Gene	sites|amod|START_ENTITY sites|nmod|phosphate phosphate|compound|END_ENTITY	Mutational analysis of putative phosphate - and proton-binding sites in the Saccharomyces_cerevisiae Pho84 phosphate : H -LRB- + -RRB- transceptor and its effect on signalling to the PKA and PHO pathways .
22628173	0	phosphate	78,87	Pho84	72,77	phosphate	Pho84	CHEBI:26020	854916(Tax:4932)	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	Enhanced arsenate uptake in Saccharomyces_cerevisiae overexpressing the Pho84 phosphate transporter .
21143198	0	phosphate	40,49	Pho87	63,68	phosphate	Pho87	CHEBI:26020	850403(Tax:4932)	Chemical	Gene	roles|nmod|START_ENTITY transporters|nsubj|roles transporters|dobj|END_ENTITY	Differential roles for the low-affinity phosphate transporters Pho87 and Pho90 in Saccharomyces_cerevisiae .
18625026	0	phosphate	30,39	Pho89	24,29	phosphate	Pho89	CHEBI:26020	852599(Tax:4932)	Chemical	Gene	START_ENTITY|nsubj|Characterization Characterization|nmod|END_ENTITY	Characterization of the Pho89 phosphate transporter by functional hyperexpression in Saccharomyces_cerevisiae .
17804816	0	phosphate	20,29	Pho91	0,5	phosphate	Pho91	CHEBI:26020	855747(Tax:4932)	Chemical	Gene	transporter|compound|START_ENTITY transporter|nsubj|END_ENTITY	Pho91 Is a vacuolar phosphate transporter that regulates phosphate and polyphosphate metabolism in Saccharomyces_cerevisiae .
17804816	0	phosphate	57,66	Pho91	0,5	phosphate	Pho91	CHEBI:26020	855747(Tax:4932)	Chemical	Gene	metabolism|amod|START_ENTITY regulates|dobj|metabolism transporter|acl:relcl|regulates transporter|nsubj|END_ENTITY	Pho91 Is a vacuolar phosphate transporter that regulates phosphate and polyphosphate metabolism in Saccharomyces_cerevisiae .
16547863	0	phosphate	37,46	Pht1	32,36	phosphate	Pht1	CHEBI:26020	542180(Tax:4577)	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|END_ENTITY	Differential regulation of five Pht1 phosphate transporters from maize -LRB- Zea_mays_L . -RRB- .
10048459	0	phosphate	40,49	PiT-1	14,19	phosphate	PiT-1	CHEBI:26020	25517(Tax:10116)	Chemical	Gene	co-transporter|compound|START_ENTITY END_ENTITY|appos|co-transporter	Regulation of PiT-1 , a sodium-dependent phosphate co-transporter in rat parathyroid glands .
15641067	0	phosphate	71,80	PiT-1	25,30	phosphate	PiT-1	CHEBI:26020	6574	Chemical	Gene	START_ENTITY|amod|interleukin-8 interleukin-8|nmod|expression expression|compound|END_ENTITY	Role of interleukin-8 in PiT-1 expression and CXCR1-mediated inorganic phosphate uptake in chondrocytes .
23968976	0	phosphate	17,26	PiT-1	131,136	phosphate	PiT-1	CHEBI:26020	18736(Tax:10090)	Chemical	Gene	cotransporters|compound|START_ENTITY cotransporters|dep|roles roles|nmod|END_ENTITY	Sodium-dependent phosphate cotransporters and phosphate-induced calcification of vascular smooth muscle cells : redundant roles for PiT-1 and PiT-2 .
25684711	0	phosphate	82,91	PiT-1	105,110	phosphate	PiT-1	CHEBI:26020	18736(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Phosphate uptake-independent signaling functions of the type III sodium-dependent phosphate transporter , PiT-1 , in vascular smooth muscle cells .
26923164	0	phosphate	75,84	PiT-1	27,32	phosphate	PiT-1	D010710	20515(Tax:10090)	Chemical	Gene	transporters|compound|START_ENTITY transporters|nsubj|transporters transporters|dep|END_ENTITY	The type III transporters -LRB- PiT-1 and PiT-2 -RRB- are the major sodium-dependent phosphate transporters in the mice and human brains .
9528951	0	phosphate	71,80	PiT-1	45,50	phosphate	PiT-1	CHEBI:26020	25517(Tax:10116)	Chemical	Gene	cotransporter|compound|START_ENTITY END_ENTITY|appos|cotransporter	Molecular cloning and hormonal regulation of PiT-1 , a sodium-dependent phosphate cotransporter from rat parathyroid glands .
11356966	0	phosphate	35,44	PiT-2	26,31	phosphate	PiT-2	CHEBI:26020	6575	Chemical	Gene	receptor|amod|START_ENTITY END_ENTITY|appos|receptor	Transmembrane topology of PiT-2 , a phosphate transporter-retrovirus receptor .
15971147	0	phosphate	34,43	PiT-2	28,33	phosphate	PiT-2	CHEBI:26020	29502(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of the rat renal PiT-2 phosphate transporter .
19726692	0	phosphate	98,107	PiT1	38,42	phosphate	PiT1	CHEBI:26020	5449	Chemical	Gene	activity|amod|START_ENTITY Identification|nmod|activity Identification|nmod|END_ENTITY	Identification of a novel function of PiT1 critical for cell proliferation and independent of its phosphate transport activity .
23376999	0	phosphate	34,43	PiT1	60,64	phosphate	PiT1	CHEBI:26020	20515(Tax:10090)	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Mice lacking the sodium-dependent phosphate import protein , PiT1 -LRB- SLC20A1 -RRB- , have a severe defect in terminal erythroid differentiation and early B cell development .
15955065	0	phosphate	197,206	PiT2	235,239	phosphate	PiT2	CHEBI:26020	6575	Chemical	Gene	function|amod|START_ENTITY function|nmod|END_ENTITY	Evolutionary and experimental analyses of inorganic phosphate transporter PiT family reveals two related signature sequences harboring highly conserved aspartic_acids critical for sodium-dependent phosphate transport function of human PiT2 .
15955065	0	phosphate	52,61	PiT2	235,239	phosphate	PiT2	CHEBI:26020	6575	Chemical	Gene	family|amod|START_ENTITY analyses|nmod|family reveals|nsubj|analyses reveals|dobj|sequences sequences|acl|harboring harboring|dobj|aspartic_acids aspartic_acids|amod|critical critical|nmod|function function|nmod|END_ENTITY	Evolutionary and experimental analyses of inorganic phosphate transporter PiT family reveals two related signature sequences harboring highly conserved aspartic_acids critical for sodium-dependent phosphate transport function of human PiT2 .
21586110	0	phosphate	33,42	PiT2	70,74	phosphate	PiT2	CHEBI:26020	6575	Chemical	Gene	START_ENTITY|acl|transporting transporting|dobj|unit unit|nmod|END_ENTITY	Mapping of the minimal inorganic phosphate transporting unit of human PiT2 suggests a structure universal to PiT-related proteins from all kingdoms of life .
16527991	0	phosphate	29,38	Pit-1	54,59	phosphate	Pit-1	CHEBI:26020	5449	Chemical	Gene	cotransporter|compound|START_ENTITY cotransporter|appos|END_ENTITY	Role of the sodium-dependent phosphate cotransporter , Pit-1 , in vascular smooth muscle cell calcification .
20709201	0	phosphate	37,46	Pit-1	140,145	phosphate	Pit-1	CHEBI:26020	18736(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|expression expression|nmod|chondrocytes chondrocytes|nmod|END_ENTITY	Signaling of extracellular inorganic phosphate up-regulates cyclin_D1 expression in proliferating chondrocytes via the Na + / Pi_cotransporter Pit-1 and Raf/MEK/ERK pathway .
21075853	0	phosphate	61,70	Pit-1	83,88	phosphate	Pit-1	CHEBI:26020	18736(Tax:10090)	Chemical	Gene	mediated|nmod|START_ENTITY END_ENTITY|amod|mediated	Cellular ATP synthesis mediated by type III sodium-dependent phosphate transporter Pit-1 is critical to chondrogenesis .
11718898	0	phosphate	56,65	Pit-2	81,86	phosphate	Pit-2	CHEBI:26020	20516(Tax:10090)	Chemical	Gene	cotransporter|compound|START_ENTITY cotransporter|appos|END_ENTITY	Molecular cloning of a murine type III sodium-dependent phosphate cotransporter -LRB- Pit-2 -RRB- gene promoter .
11932396	0	phosphate	77,86	Pit2	0,4	phosphate	Pit2	CHEBI:26020	6575	Chemical	Gene	concentration|amod|START_ENTITY modulated|nmod|concentration modulated|nsubjpass|assemblies assemblies|amod|END_ENTITY	Pit2 assemblies at the cell surface are modulated by extracellular inorganic phosphate concentration .
15184021	0	phosphate	119,128	Pit2	20,24	phosphate	Pit2	CHEBI:26020	6575	Chemical	Gene	modify|nmod|START_ENTITY modify|nsubj|transporters transporters|amod|END_ENTITY	Transport-deficient Pit2 phosphate transporters still modify cell surface oligomers structure in response to inorganic phosphate .
15184021	0	phosphate	25,34	Pit2	20,24	phosphate	Pit2	CHEBI:26020	6575	Chemical	Gene	transporters|compound|START_ENTITY transporters|amod|END_ENTITY	Transport-deficient Pit2 phosphate transporters still modify cell surface oligomers structure in response to inorganic phosphate .
7026529	0	phosphate	58,67	Pst	44,47	phosphate	Pst	CHEBI:26020	6817	Chemical	Gene	system|compound|START_ENTITY system|compound|END_ENTITY	Genetic analysis of mutants affected in the Pst inorganic phosphate transport system .
17562688	3	phosphate	451,460	TaPT2	474,479	phosphate	TaPT2	CHEBI:26020	543106(Tax:4565)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	In this study , the expression pattern of one putative wheat high-affinity phosphate transporter , TaPT2 , was examined in roots and leaves under Pi-deficient conditions .
22675212	0	phosphate	26,35	Wunen	0,5	phosphate	Wunen	CHEBI:26020	35966(Tax:7227)	Chemical	Gene	phosphatase|compound|START_ENTITY END_ENTITY|appos|phosphatase	Wunen , a Drosophila lipid phosphate phosphatase , is required for septate junction-mediated barrier function .
10606765	0	phosphate	27,36	adenosine_kinase	56,72	phosphate	adenosine kinase	CHEBI:26020	100736551	Chemical	Gene	influence|nmod|START_ENTITY influence|nmod|activity activity|nmod|END_ENTITY	The influence of inorganic phosphate on the activity of adenosine_kinase .
12377057	0	phosphate	77,86	aminopeptidase	149,163	phosphate	aminopeptidase	CHEBI:26020	10404	Chemical	Gene	binding|amod|START_ENTITY END_ENTITY|amod|binding	Paramagnetic cobalt -LRB- II -RRB- as a probe for kinetic and NMR relaxation studies of phosphate binding and the catalytic mechanism of Streptomyces dinuclear aminopeptidase .
1872896	0	phosphate	32,41	angiotensin_II	14,28	phosphate	angiotensin II	CHEBI:26020	24179(Tax:10116)	Chemical	Gene	transport|amod|START_ENTITY END_ENTITY|nmod|transport	Regulation by angiotensin_II of phosphate transport in cardiac myocytes .
2521395	0	phosphate	49,58	atrial_natriuretic_factor	4,29	phosphate	atrial natriuretic factor	CHEBI:26020	24602(Tax:10116)	Chemical	Gene	transport|amod|START_ENTITY inhibits|dobj|transport inhibits|nsubj|END_ENTITY	Rat atrial_natriuretic_factor -LRB- ANP-III -RRB- inhibits phosphate transport in brush border membrane from superficial and juxtamedullary cortex .
10200992	0	phosphate	113,122	calcium-sensing_receptor	10,34	phosphate	calcium-sensing receptor	CHEBI:26020	24247(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY expression|dep|role expression|amod|END_ENTITY	Decreased calcium-sensing_receptor expression in hyperplastic parathyroid glands of uremic rats : role of dietary phosphate .
20709201	0	phosphate	37,46	cyclin_D1	60,69	phosphate	cyclin D1	CHEBI:26020	12443(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|expression expression|amod|END_ENTITY	Signaling of extracellular inorganic phosphate up-regulates cyclin_D1 expression in proliferating chondrocytes via the Na + / Pi_cotransporter Pit-1 and Raf/MEK/ERK pathway .
9200705	0	phosphate	61,70	deoxycytidine_kinase	26,46	phosphate	deoxycytidine kinase	CHEBI:26020	1633	Chemical	Gene	donor|compound|START_ENTITY END_ENTITY|nmod|donor	Kinetic analysis of human deoxycytidine_kinase with the true phosphate donor uridine_triphosphate .
11500953	0	phosphate	51,60	endothelin-1	22,34	phosphate	endothelin-1	CHEBI:26020	13614(Tax:10090)	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|nmod|transport	Stimulatory effect of endothelin-1 on Na-dependent phosphate transport and its signaling mechanism in osteoblast-like cells .
9171303	0	phosphate	27,36	endothelin_1	11,23	phosphate	endothelin 1	CHEBI:26020	24323(Tax:10116)	Chemical	Gene	transport|amod|START_ENTITY END_ENTITY|nmod|transport	Effects of endothelin_1 on phosphate transport in brush border membrane vesicles .
17136110	0	phosphate	13,22	era	6,9	phosphate	era	CHEBI:26020	26284	Chemical	Gene	therapy|amod|START_ENTITY END_ENTITY|nmod|therapy	A new era in phosphate binder therapy : what are the options ?
1341057	0	phosphate	10,19	fibrinogen	31,41	phosphate	fibrinogen	CHEBI:26020	2244	Chemical	Gene	content|amod|START_ENTITY content|nmod|END_ENTITY	Increased phosphate content of fibrinogen in vivo correlates with alteration in fibrinogen behaviour .
3697510	0	phosphate	25,34	fibrinogen	46,56	phosphate	fibrinogen	CHEBI:26020	2244	Chemical	Gene	content|amod|START_ENTITY content|nmod|END_ENTITY	Fibrinopeptide_A and the phosphate content of fibrinogen in venous_thromboembolism and disseminated intravascular_coagulation .
16105045	0	phosphate	41,50	fibroblast_growth_factor-23	10,37	phosphate	fibroblast growth factor-23	CHEBI:26020	64654(Tax:10090)	Chemical	Gene	transport|amod|START_ENTITY END_ENTITY|nmod|transport	Effect of fibroblast_growth_factor-23 on phosphate transport in proximal tubules .
18826855	0	phosphate	87,96	fibroblast_growth_factor-23	46,73	phosphate	fibroblast growth factor-23	CHEBI:26020	64654(Tax:10090)	Chemical	Gene	intake|amod|START_ENTITY intake|amod|high high|amod|END_ENTITY	Osteoprotegerin affects the responsiveness of fibroblast_growth_factor-23 to high oral phosphate intake .
21030580	0	phosphate	19,28	fibroblast_growth_factor-23	51,78	phosphate	fibroblast growth factor-23	CHEBI:26020	8074	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of dietary phosphate and calcium intake on fibroblast_growth_factor-23 .
22450330	0	phosphate	75,84	fibroblast_growth_factor-23	31,58	phosphate	fibroblast growth factor-23	CHEBI:26020	428104(Tax:9031)	Chemical	Gene	requirements|amod|START_ENTITY reduced|dobj|requirements reduced|nsubj|antibody antibody|nmod|END_ENTITY	Maternally-derived antibody to fibroblast_growth_factor-23 reduced dietary phosphate requirements in growing chicks .
22796419	0	phosphate	106,115	fibroblast_growth_factor-23	52,79	phosphate	fibroblast growth factor-23	CHEBI:26020	8074	Chemical	Gene	wasting|compound|START_ENTITY determines|dobj|wasting determines|nsubj|vintage vintage|amod|END_ENTITY	Dialysis vintage and parathyroid_hormone level , not fibroblast_growth_factor-23 , determines chronic-phase phosphate wasting after renal transplantation .
23085728	0	phosphate	66,75	fibroblast_growth_factor-23	27,54	phosphate	fibroblast growth factor-23	CHEBI:26020	8074	Chemical	Gene	excretion|compound|START_ENTITY END_ENTITY|nmod|excretion	Association of circulating fibroblast_growth_factor-23 with renal phosphate excretion among hemodialysis patients with residual_renal_function .
26617686	0	phosphate	103,112	fibroblast_growth_factor_2	51,77	phosphate	fibroblast growth factor 2	D010710	2247	Chemical	Gene	kinase|amod|START_ENTITY kinase|amod|END_ENTITY	Expression of fibroblast_growth_factor_receptor_1 , fibroblast_growth_factor_2 , phosphatidyl_inositol 3 phosphate kinase and their clinical and prognostic significance in early and advanced stage of squamous cell carcinoma_of_the_lung .
19669798	0	phosphate	14,23	fibroblast_growth_factor_23	37,64	phosphate	fibroblast growth factor 23	CHEBI:26020	8074	Chemical	Gene	transport|amod|START_ENTITY transport|nmod|END_ENTITY	Regulation of phosphate transport by fibroblast_growth_factor_23 -LRB- FGF23 -RRB- : implications for disorders of phosphate metabolism .
26617686	0	phosphate	103,112	fibroblast_growth_factor_receptor_1	14,49	phosphate	fibroblast growth factor receptor 1	D010710	2260	Chemical	Gene	kinase|amod|START_ENTITY kinase|amod|END_ENTITY	Expression of fibroblast_growth_factor_receptor_1 , fibroblast_growth_factor_2 , phosphatidyl_inositol 3 phosphate kinase and their clinical and prognostic significance in early and advanced stage of squamous cell carcinoma_of_the_lung .
8298499	0	phosphate	20,29	glutathione_reductase	68,89	phosphate	glutathione reductase	CHEBI:26020	2936	Chemical	Gene	START_ENTITY|nmod|properties properties|nmod|END_ENTITY	Effect of inorganic phosphate on the self-associating properties of glutathione_reductase from Spirulina maxima .
3126802	0	phosphate	10,19	glycogen_phosphorylase_b	28,52	phosphate	glycogen phosphorylase b	CHEBI:26020	5834	Chemical	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Pyridoxal phosphate site in glycogen_phosphorylase_b : structure in native enzyme and in three derivatives with modified cofactors .
21252245	0	phosphate	15,24	growth_hormone	101,115	phosphate	growth hormone	CHEBI:26020	2688	Chemical	Gene	Effect|nmod|START_ENTITY Effect|acl|END_ENTITY	Effect of oral phosphate and alendronate on bone_mineral_density when given as adjunctive therapy to growth_hormone replacement in adult_growth_hormone_deficiency .
2206908	0	phosphate	20,29	growth_hormone	96,110	phosphate	growth hormone	CHEBI:26020	81668(Tax:10116)	Chemical	Gene	reabsorption|compound|START_ENTITY Regulation|nmod|reabsorption Regulation|dep|implications implications|nmod|model model|nmod|deficiency deficiency|amod|END_ENTITY	Regulation of renal phosphate reabsorption during development : implications from a new model of growth_hormone deficiency .
3838075	0	phosphate	58,67	growth_hormone	105,119	phosphate	growth hormone	CHEBI:26020	81668(Tax:10116)	Chemical	Gene	deprivation|amod|START_ENTITY synthesis|nmod|deprivation Activation|nmod|synthesis Activation|dep|evidence evidence|nmod|role role|nmod|END_ENTITY	Activation of renal 1,25-dihydroxyvitamin _ D3 synthesis by phosphate deprivation : evidence for a role for growth_hormone .
4221826	0	phosphate	38,47	growth_hormone	13,27	phosphate	growth hormone	CHEBI:26020	2688	Chemical	Gene	metabolism|compound|START_ENTITY effect|nmod|metabolism effect|nmod|END_ENTITY	An effect of growth_hormone on hexose phosphate metabolism .
7863823	0	phosphate	64,73	growth_hormone	16,30	phosphate	growth hormone	CHEBI:26020	2688	Chemical	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of growth_hormone and parathyroid_hormone in renal phosphate , calcium , and calcitriol metabolism and bone remodeling in postmenopausal women .
7949804	0	phosphate	22,31	growth_hormone	52,66	phosphate	growth hormone	CHEBI:26020	2688	Chemical	Gene	handling|nmod|START_ENTITY predict|nsubj|handling predict|advcl|END_ENTITY	Can renal handling of phosphate predict response to growth_hormone therapy in normal variant short children by short-term treatment ?
105228	0	phosphate	38,47	insulin	11,18	phosphate	insulin	CHEBI:26020	3630	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|infusion infusion|compound|END_ENTITY	Effects of insulin infusion on plasma phosphate in diabetic patients .
8637455	0	phosphate	29,38	insulin	10,17	phosphate	insulin	CHEBI:26020	3630	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of insulin on urinary phosphate excretion in type_II_diabetes_mellitus with or without renal_insufficiency .
7595027	0	phosphate	43,52	insulin-like_growth_factor_I	11,39	phosphate	insulin-like growth factor I	CHEBI:26020	3479	Chemical	Gene	transport|amod|START_ENTITY Effects|nmod|transport Effects|nmod|END_ENTITY	Effects of insulin-like_growth_factor_I on phosphate transport in cultured proximal tubule cells .
8895336	0	phosphate	25,34	insulin-like_growth_factor_I	48,76	phosphate	insulin-like growth factor I	CHEBI:26020	3479	Chemical	Gene	transport|compound|START_ENTITY transport|nmod|END_ENTITY	Stimulation of inorganic phosphate transport by insulin-like_growth_factor_I and vanadate in opossum kidney cells is mediated by distinct protein tyrosine phosphorylation processes .
19729436	0	phosphate	39,48	npt2b	11,16	phosphate	npt2b	CHEBI:26020	20531(Tax:10090)	Chemical	Gene	absorption|amod|START_ENTITY plays|nmod|absorption plays|nsubj|END_ENTITY	Intestinal npt2b plays a major role in phosphate absorption and homeostasis .
24700685	0	phosphate	10,19	osteopontin	117,128	phosphate	osteopontin	D010710	6696	Chemical	Gene	induces|nsubj|START_ENTITY induces|xcomp|dependent dependent|nmod|C2 C2|acl|regulated regulated|dobj|expression expression|compound|END_ENTITY	Inorganic phosphate induces cancer cell mediated angiogenesis dependent on forkhead box protein C2 -LRB- FOXC2 -RRB- regulated osteopontin expression .
10731661	0	phosphate	88,97	p58	39,42	phosphate	p58	CHEBI:26020	301323(Tax:10116)	Chemical	Gene	cotransporter|compound|START_ENTITY END_ENTITY|appos|cotransporter	Ganglioside GT1b in rat brain binds to p58 , a brain-specific sodium-dependent inorganic phosphate cotransporter : expression cloning with a specific monoclonal antibody to ganglioside GT1b-binding protein .
8366986	0	phosphate	66,75	parathyroid-hormone-related_protein	10,45	phosphate	parathyroid-hormone-related protein	CHEBI:26020	24695(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|nmod|transport	Effect of parathyroid-hormone-related_protein on sodium-dependent phosphate transport in renal brush border membrane vesicles in rats .
10571684	0	phosphate	10,19	parathyroid_hormone	23,42	phosphate	parathyroid hormone	CHEBI:26020	403986(Tax:9615)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|amod|END_ENTITY	Effect of phosphate on parathyroid_hormone secretion in vivo .
1113683	0	phosphate	54,63	parathyroid_hormone	14,33	phosphate	parathyroid hormone	CHEBI:26020	403986(Tax:9615)	Chemical	Gene	homeostasis|amod|START_ENTITY required|nmod|homeostasis required|nsubjpass|Evidence Evidence|acl:relcl|END_ENTITY	Evidence that parathyroid_hormone is not required for phosphate homeostasis in renal_failure .
1211488	0	phosphate	48,57	parathyroid_hormone	25,44	phosphate	parathyroid hormone	CHEBI:26020	403986(Tax:9615)	Chemical	Gene	reabsorption|amod|START_ENTITY site|nmod|reabsorption site|nmod|END_ENTITY	Distal site of action of parathyroid_hormone on phosphate reabsorption .
1422972	0	phosphate	34,43	parathyroid_hormone	63,82	phosphate	parathyroid hormone	CHEBI:26020	5741	Chemical	Gene	treatment|compound|START_ENTITY treatment|nmod|END_ENTITY	Effects of a short course of oral phosphate treatment on serum parathyroid_hormone -LRB- 1-84 -RRB- and biochemical markers of bone turnover : a dose-response study .
15775258	0	phosphate	39,48	parathyroid_hormone	10,29	phosphate	parathyroid hormone	CHEBI:26020	5741	Chemical	Gene	-RSB-|amod|START_ENTITY Roles|nmod|-RSB- Roles|nmod|END_ENTITY	-LSB- Roles of parathyroid_hormone -LRB- PTH -RRB- on phosphate metabolism -RSB- .
15914507	0	phosphate	51,60	parathyroid_hormone	20,39	phosphate	parathyroid hormone	CHEBI:26020	24694(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Acute regulation of parathyroid_hormone by dietary phosphate .
16514432	0	phosphate	14,23	parathyroid_hormone	120,139	phosphate	parathyroid hormone	CHEBI:26020	24694(Tax:10116)	Chemical	Gene	NaPi-IIa|amod|START_ENTITY internalized|nsubjpass|NaPi-IIa internalized|xcomp|END_ENTITY	The renal Na + / phosphate cotransporter NaPi-IIa is internalized via the receptor-mediated endocytic route in response to parathyroid_hormone .
175088	0	phosphate	121,130	parathyroid_hormone	58,77	phosphate	parathyroid hormone	CHEBI:26020	24694(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Renal adenylate cyclase and the interrelationship between parathyroid_hormone and vitamin_D in the regulation of urinary phosphate and adenosine_cyclic_3 ' ,5 ' - monophosphate excretion .
17703091	0	phosphate	32,41	parathyroid_hormone	43,62	phosphate	parathyroid hormone	CHEBI:26020	5741	Chemical	Gene	pressure|amod|START_ENTITY pressure|amod|nondipper nondipper|dep|END_ENTITY	Relation between serum calcium , phosphate , parathyroid_hormone and ` nondipper ' circadian blood pressure variability profile in patients with normal renal function .
183512	0	phosphate	32,41	parathyroid_hormone	60,79	phosphate	parathyroid hormone	CHEBI:26020	24694(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of colchicine on urinary phosphate and regulation by parathyroid_hormone .
18616960	0	phosphate	149,158	parathyroid_hormone	209,228	phosphate	parathyroid hormone	CHEBI:26020	5741	Chemical	Gene	absorption|compound|START_ENTITY stimulate|dobj|absorption stimulate|nmod|levels levels|acl|shown shown|xcomp|suppress suppress|dobj|END_ENTITY	2-methylene-19-nor-20 -LRB- S -RRB- -1 alpha-hydroxy-bishomopregnacalciferol -LSB- 20 -LRB- S -RRB- -2 MbisP -RSB- , an analog of vitamin_D3 -LSB- 1,25 -LRB- OH -RRB- 2D3 -RSB- , does not stimulate intestinal phosphate absorption at levels previously shown to suppress parathyroid_hormone .
19394454	0	phosphate	95,104	parathyroid_hormone	22,41	phosphate	parathyroid hormone	CHEBI:26020	5741	Chemical	Gene	administration|compound|START_ENTITY differences|nmod|administration differences|nmod|secretion secretion|amod|END_ENTITY	Ethnic differences in parathyroid_hormone secretion and mineral metabolism in response to oral phosphate administration .
19569018	0	phosphate	54,63	parathyroid_hormone	19,38	phosphate	parathyroid hormone	CHEBI:26020	5741	Chemical	Gene	load|amod|START_ENTITY secretion|nmod|load secretion|amod|END_ENTITY	-LSB- Responsiveness of parathyroid_hormone secretion to a phosphate load in hypertensive patients with non_insulin_dependent_diabetes_mellitus -RSB- .
20403518	0	phosphate	133,142	parathyroid_hormone	167,186	phosphate	parathyroid hormone	CHEBI:26020	5741	Chemical	Gene	START_ENTITY|nmod|control control|nmod|release release|amod|END_ENTITY	Acute parathyroid_hormone increase by oral peptones administration after roux-en-Y_gastric_bypass surgery in obese subjects : role of phosphate in the rapid control of parathyroid_hormone release .
20403518	0	phosphate	133,142	parathyroid_hormone	6,25	phosphate	parathyroid hormone	CHEBI:26020	5741	Chemical	Gene	role|nmod|START_ENTITY increase|dep|role increase|compound|END_ENTITY	Acute parathyroid_hormone increase by oral peptones administration after roux-en-Y_gastric_bypass surgery in obese subjects : role of phosphate in the rapid control of parathyroid_hormone release .
20526720	0	phosphate	79,88	parathyroid_hormone	6,25	phosphate	parathyroid hormone	CHEBI:26020	24694(Tax:10116)	Chemical	Gene	cotransporters|amod|START_ENTITY membrane|dobj|cotransporters border|acl|membrane regulates|dobj|border regulates|nsubj|END_ENTITY	Acute parathyroid_hormone differentially regulates renal brush border membrane phosphate cotransporters .
2104263	0	phosphate	25,34	parathyroid_hormone	95,114	phosphate	parathyroid hormone	CHEBI:26020	24694(Tax:10116)	Chemical	Gene	propranolol|nmod|START_ENTITY Effect|nmod|propranolol reabsorption|nsubj|Effect reabsorption|xcomp|END_ENTITY	Effect of propranolol on phosphate reabsorption by superficial nephron segments in response to parathyroid_hormone in phosphate-deprived rats .
21047792	0	phosphate	42,51	parathyroid_hormone	149,168	phosphate	parathyroid hormone	CHEBI:26020	5741	Chemical	Gene	NPT2a|compound|START_ENTITY down-regulation|nmod|NPT2a involves|nsubj|down-regulation involves|advcl|revealed revealed|nmod|analogs analogs|compound|END_ENTITY	Acute down-regulation of sodium-dependent phosphate transporter NPT2a involves predominantly the cAMP/PKA pathway as revealed by signaling-selective parathyroid_hormone analogs .
2177031	0	phosphate	146,155	parathyroid_hormone	43,62	phosphate	parathyroid hormone	CHEBI:26020	24694(Tax:10116)	Chemical	Gene	deprivation|amod|START_ENTITY effect|nmod|deprivation Bioactivity|dep|effect Bioactivity|nmod|fragments fragments|nmod|peptide peptide|amod|END_ENTITY	Bioactivity of amino terminal fragments of parathyroid_hormone and parathyroid_hormone related peptide in rat kidney slices : no effect of dietary phosphate deprivation .
2247335	0	phosphate	24,33	parathyroid_hormone	88,107	phosphate	parathyroid hormone	CHEBI:26020	5741	Chemical	Gene	transport|amod|START_ENTITY asymmetry|nmod|transport asymmetry|dep|inhibition inhibition|amod|END_ENTITY	Functional asymmetry in phosphate transport and its regulation in opossum kidney cells : parathyroid_hormone inhibition .
2419328	0	phosphate	17,26	parathyroid_hormone	50,69	phosphate	parathyroid hormone	CHEBI:26020	280903(Tax:9913)	Chemical	Gene	transport|compound|START_ENTITY inhibited|nsubj|transport inhibited|nmod|stimulation stimulation|compound|END_ENTITY	Sodium-dependent phosphate transport inhibited by parathyroid_hormone and cyclic_AMP stimulation in an opossum kidney cell line .
24979301	0	phosphate	5,14	parathyroid_hormone	60,79	phosphate	parathyroid hormone	CHEBI:26020	24694(Tax:10116)	Chemical	Gene	diet|compound|START_ENTITY increases|nsubj|diet increases|dobj|pressure pressure|nmod|increase increase|amod|END_ENTITY	High phosphate diet increases arterial blood pressure via a parathyroid_hormone mediated increase of renin .
3096150	0	phosphate	43,52	parathyroid_hormone	11,30	phosphate	parathyroid hormone	CHEBI:26020	24694(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of parathyroid_hormone and urinary phosphate on collecting duct hydrogen secretion .
3366359	0	phosphate	85,94	parathyroid_hormone	15,34	phosphate	parathyroid hormone	CHEBI:26020	5741	Chemical	Gene	transport|compound|START_ENTITY amide|nmod|transport -LSB-|parataxis|amide -LSB-|nsubj|Effects Effects|nmod|antagonist antagonist|amod|END_ENTITY	Effects of the parathyroid_hormone antagonist -LSB- Tyr34 -RSB- bPTH - -LRB- 7-34 -RRB- amide on avian renal phosphate transport .
34630	0	phosphate	82,91	parathyroid_hormone	55,74	phosphate	parathyroid hormone	CHEBI:26020	24694(Tax:10116)	Chemical	Gene	depletion|amod|START_ENTITY Resistance|nmod|depletion Resistance|nmod|actions actions|nmod|END_ENTITY	Resistance to the phosphaturic and calcemic actions of parathyroid_hormone during phosphate depletion .
418459	0	phosphate	27,36	parathyroid_hormone	88,107	phosphate	parathyroid hormone	CHEBI:26020	101120013	Chemical	Gene	loading|compound|START_ENTITY effects|nmod|loading END_ENTITY|nsubj|effects	The effects of intravenous phosphate loading on salivary phosphate secretion and plasma parathyroid_hormone levels in the sheep .
418459	0	phosphate	57,66	parathyroid_hormone	88,107	phosphate	parathyroid hormone	CHEBI:26020	101120013	Chemical	Gene	secretion|amod|START_ENTITY loading|nmod|secretion effects|nmod|loading END_ENTITY|nsubj|effects	The effects of intravenous phosphate loading on salivary phosphate secretion and plasma parathyroid_hormone levels in the sheep .
4322720	0	phosphate	96,105	parathyroid_hormone	18,37	phosphate	parathyroid hormone	CHEBI:26020	403986(Tax:9615)	Chemical	Gene	reabsorption|compound|START_ENTITY monophosphate|nmod|reabsorption Mode|dep|monophosphate Mode|nmod|action action|nmod|END_ENTITY	Mode of action of parathyroid_hormone and cyclic_adenosine_3 ' ,5 ' - monophosphate on renal tubular phosphate reabsorption in the dog .
5475987	0	phosphate	12,21	parathyroid_hormone	42,61	phosphate	parathyroid hormone	CHEBI:26020	5741	Chemical	Gene	role|nmod|START_ENTITY role|nmod|secretion secretion|nmod|END_ENTITY	The role of phosphate in the secretion of parathyroid_hormone in man .
548599	0	phosphate	110,119	parathyroid_hormone	51,70	phosphate	parathyroid hormone	CHEBI:26020	24694(Tax:10116)	Chemical	Gene	retention|amod|START_ENTITY caused|nmod|retention caused|csubjpass|Evidence Evidence|nmod|action action|nmod|END_ENTITY	Evidence that resistance to the calcemic action of parathyroid_hormone in rats with acute uremia is caused by phosphate retention .
6090236	0	phosphate	9,18	parathyroid_hormone	112,131	phosphate	parathyroid hormone	CHEBI:26020	5741	Chemical	Gene	START_ENTITY|dobj|response response|nmod|administration administration|nmod|END_ENTITY	-LSB- Urinary phosphate and cyclic_adenosine_monophosphate response to intravenous administration of synthetic human parathyroid_hormone - -LRB- 1-34 -RRB- in idiopathic_hypoparathyroidism , pseudohypoparathyroidism , pseudopseudohypoparathyroidism and normal subjects -RSB- .
6294581	0	phosphate	98,107	parathyroid_hormone	10,29	phosphate	parathyroid hormone	CHEBI:26020	5741	Chemical	Gene	formation|nmod|START_ENTITY Effect|nmod|formation Effect|nmod|END_ENTITY	Effect of parathyroid_hormone on cAMP and 1,25-dihydroxyvitamin _ D formation and renal handling of phosphate in vitamin_D-dependent_rickets .
6305645	0	phosphate	86,95	parathyroid_hormone	41,60	phosphate	parathyroid hormone	CHEBI:26020	24694(Tax:10116)	Chemical	Gene	depletion|amod|START_ENTITY Refractoriness|nmod|depletion Refractoriness|nmod|action action|nmod|END_ENTITY	Refractoriness to phosphaturic action of parathyroid_hormone occurring independent of phosphate depletion in hyperparathyroid rats .
6314912	0	phosphate	47,56	parathyroid_hormone	10,29	phosphate	parathyroid hormone	CHEBI:26020	403986(Tax:9615)	Chemical	Gene	transport|amod|START_ENTITY Effect|dep|transport Effect|nmod|END_ENTITY	Effect of parathyroid_hormone on Na + - dependent phosphate transport and cAMP-dependent 32P phosphorylation in brush border vesicles from isolated perfused canine kidneys .
6330514	0	phosphate	124,133	parathyroid_hormone	11,30	phosphate	parathyroid hormone	CHEBI:26020	100351309(Tax:9986)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of parathyroid_hormone and calcitonin on stop-flow patterns of cyclic_AMP , sodium , potassium , calcium and inorganic phosphate in thyroparathyroidectomized rabbits .
6514672	0	phosphate	63,72	parathyroid_hormone	10,29	phosphate	parathyroid hormone	CHEBI:26020	5741	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of parathyroid_hormone on total phosphate and inorganic phosphate in blood , plasma , and urine of domestic fowl .
6696117	0	phosphate	25,34	parathyroid_hormone	59,78	phosphate	parathyroid hormone	CHEBI:26020	24694(Tax:10116)	Chemical	Gene	reabsorption|amod|START_ENTITY heterogeneity|nmod|reabsorption heterogeneity|dep|effect effect|nmod|END_ENTITY	Nephron heterogeneity of phosphate reabsorption : effect of parathyroid_hormone .
6709951	0	phosphate	67,76	parathyroid_hormone	118,137	phosphate	parathyroid hormone	CHEBI:26020	24694(Tax:10116)	Chemical	Gene	reabsorption|nmod|START_ENTITY inhibition|nmod|reabsorption inhibition|nmod|tubule tubule|nmod|absence absence|nmod|END_ENTITY	Glucocorticoid-induced inhibition of the reabsorption of inorganic phosphate in the proximal tubule in the absence of parathyroid_hormone .
7804449	0	phosphate	71,80	parathyroid_hormone	94,113	phosphate	parathyroid hormone	CHEBI:26020	24694(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY stimulation|nmod|transport C|nmod|stimulation kinase|dobj|C kinase|nmod|END_ENTITY	Involvement of protein kinase C in the stimulation of sodium-dependent phosphate transport by parathyroid_hormone in osteoblast-like cells .
787619	0	phosphate	33,42	parathyroid_hormone	10,29	phosphate	parathyroid hormone	CHEBI:26020	403986(Tax:9615)	Chemical	Gene	reabsorption|amod|START_ENTITY Effect|nmod|reabsorption Effect|nmod|END_ENTITY	Effect of parathyroid_hormone on phosphate reabsorption in the presence of acetazolamide .
8338927	0	phosphate	19,28	parathyroid_hormone	37,56	phosphate	parathyroid hormone	CHEBI:26020	5741	Chemical	Gene	Elevation|nmod|START_ENTITY affects|nsubj|Elevation affects|dobj|levels levels|amod|END_ENTITY	Elevation of serum phosphate affects parathyroid_hormone levels in only 50 % of hemodialysis patients , which is unrelated to changes in serum calcium .
879321	0	phosphate	12,21	parathyroid_hormone	35,54	phosphate	parathyroid hormone	CHEBI:26020	100351309(Tax:9986)	Chemical	Gene	transport|amod|START_ENTITY Response|nmod|transport Response|acl|END_ENTITY	Response of phosphate transport to parathyroid_hormone in segments of rabbit nephron .
8970892	0	phosphate	19,28	parathyroid_hormone	39,58	phosphate	parathyroid hormone	CHEBI:26020	5741	Chemical	Gene	increases|amod|START_ENTITY intake|nmod|increases END_ENTITY|nsubj|intake	An acute intake of phosphate increases parathyroid_hormone secretion and inhibits bone formation in young women .
899922	0	phosphate	77,86	parathyroid_hormone	19,38	phosphate	parathyroid hormone	CHEBI:26020	5741	Chemical	Gene	reabsorption|nmod|START_ENTITY influence|nmod|reabsorption influence|nmod|END_ENTITY	Minor influence of parathyroid_hormone on fractional tubular reabsorption of phosphate in chronic_renal_failure .
899923	0	phosphate	36,45	parathyroid_hormone	67,86	phosphate	parathyroid hormone	CHEBI:26020	5741	Chemical	Gene	reabsorption|nmod|START_ENTITY reabsorption|nmod|END_ENTITY	The maximal tubular reabsorption of phosphate in relation to serum parathyroid_hormone .
9610844	0	phosphate	81,90	parathyroid_hormone	31,50	phosphate	parathyroid hormone	CHEBI:26020	5741	Chemical	Gene	transport|compound|START_ENTITY C|nmod|transport mediates|dep|C mediates|dep|effect effect|nmod|kinase kinase|compound|END_ENTITY	20-HETE mediates the effect of parathyroid_hormone and protein kinase C on renal phosphate transport .
9690090	0	phosphate	14,23	parathyroid_hormone	62,81	phosphate	parathyroid hormone	CHEBI:26020	5741	Chemical	Gene	transport|amod|START_ENTITY transport|nmod|tubule tubule|nmod|receptor receptor|amod|END_ENTITY	Regulation of phosphate transport in the renal tubule through parathyroid_hormone receptor : unexpected pathways .
9853280	0	phosphate	16,25	parathyroid_hormone	29,48	phosphate	parathyroid hormone	CHEBI:26020	5741	Chemical	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	Effect of serum phosphate on parathyroid_hormone secretion during hemodialysis .
14585826	0	phosphate	21,30	phosphoenolpyruvate_carboxylase	34,65	phosphate	phosphoenolpyruvate carboxylase	CHEBI:26020	5105	Chemical	Gene	START_ENTITY|nmod|hypochondriacus hypochondriacus|amod|END_ENTITY	Marked modulation by phosphate of phosphoenolpyruvate_carboxylase in leaves of Amaranthus hypochondriacus , a NAD-ME type C4 plant : decrease in malate sensitivity but no change in the phosphorylation status .
24435995	0	phosphate	23,32	phosphoenolpyruvate_carboxylase	58,89	phosphate	phosphoenolpyruvate carboxylase	CHEBI:26020	5105	Chemical	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	-LSB- The role of inorganic phosphate in the regulation of the phosphoenolpyruvate_carboxylase of Mesembryanthemum crystallinum L -RSB- .
2712576	0	phosphate	34,43	phosphoenolpyruvate_carboxylase	86,117	phosphate	phosphoenolpyruvate carboxylase	CHEBI:26020	5105	Chemical	Gene	phosphates|amod|START_ENTITY effects|nmod|phosphates study|nmod|effects study|nmod|activity activity|nmod|END_ENTITY	A kinetic study of the effects of phosphate and organic phosphates on the activity of phosphoenolpyruvate_carboxylase from Crassula argentea .
12067853	0	phosphate	23,32	prolactin	10,19	phosphate	prolactin	CHEBI:26020	19109(Tax:10090)	Chemical	Gene	transport|amod|START_ENTITY Effect|nmod|transport Effect|nmod|END_ENTITY	Effect of prolactin on phosphate transport and incorporation in mouse mammary gland explants .
19616422	0	phosphate	44,53	prostaglandin_D2	11,27	phosphate	prostaglandin D2	CHEBI:26020	19215(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of prostaglandin_D2 on Na-dependent phosphate transport activity and its intracellular signaling mechanism in osteoblast-like cells .
14614572	0	phosphate	30,39	ribonuclease	61,73	phosphate	ribonuclease	CHEBI:26020	853222(Tax:4932)	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Structure and expression of a phosphate deficiency-inducible ribonuclease gene in Pholiota nameko .
24236156	0	phosphate	19,28	sclerostin	99,109	phosphate	sclerostin	CHEBI:26020	80722(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|dep|role role|nmod|END_ENTITY	Effects of dietary phosphate on adynamic bone_disease in rats with chronic_kidney_disease -- role of sclerostin ?
3034877	0	phosphate	15,24	thrombin	54,62	phosphate	thrombin	CHEBI:26020	2147	Chemical	Gene	Stimulation|nmod|START_ENTITY uptake|nsubj|Stimulation uptake|nmod|END_ENTITY	Stimulation of phosphate uptake in human platelets by thrombin and collagen .
590505	0	phosphate	63,72	vasopressin	22,33	phosphate	vasopressin	CHEBI:26020	551	Chemical	Gene	stimulation|nmod|START_ENTITY stimulation|nmod|END_ENTITY	Rapid stimulation , by vasopressin and adrenaline , of inorganic phosphate incorporation into phosphatidyl_inositol in isolated hepatocytes .
15885032	0	phosphate	50,59	vitamin_D_receptor	12,30	phosphate	vitamin D receptor	CHEBI:26020	22337(Tax:10090)	Chemical	Gene	metabolism|amod|START_ENTITY Role|nmod|metabolism Role|nmod|END_ENTITY	Role of the vitamin_D_receptor in FGF23 action on phosphate metabolism .
26264689	0	phosphate_ester	92,107	carbohydrate-response_element-binding_protein	127,172	phosphate ester	carbohydrate-response element-binding protein	null	51085	Chemical	Gene	homeostasis|compound|START_ENTITY homeostasis|nmod|END_ENTITY	Dietary carbohydrate and control of hepatic gene expression : mechanistic links from ATP and phosphate_ester homeostasis to the carbohydrate-response_element-binding_protein .
20601405	0	phosphate_ester	57,72	dUTPase	87,94	phosphate ester	dUTPase	null	34529(Tax:7227)	Chemical	Gene	hydrolysis|compound|START_ENTITY hydrolysis|nmod|END_ENTITY	Aromatic stacking between nucleobase and enzyme promotes phosphate_ester hydrolysis in dUTPase .
3611094	0	phosphates	9,19	microtubule-associated_protein_2	23,55	phosphates	microtubule-associated protein 2	MESH:D010710	25595(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|brain brain|amod|END_ENTITY	Numerous phosphates of microtubule-associated_protein_2 in living rat brain .
25359770	0	phosphatidate	53,66	Pah1	48,52	phosphatidate	Pah1	CHEBI:16337	855201(Tax:4932)	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|amod|END_ENTITY	Yeast Nem1-Spo7 protein phosphatase activity on Pah1 phosphatidate phosphatase is specific for the Pho85-Pho80 protein kinase phosphorylation sites .
10488110	0	phosphatidate	45,58	cyclooxygenase-2	14,30	phosphatidate	cyclooxygenase-2	CHEBI:16337	5743	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of cyclooxygenase-2 expression by phosphatidate phosphohydrolase in human amnionic WISH cells .
17486115	0	phosphatidic_acid	27,44	EGFR	53,57	phosphatidic acid	EGFR	MESH:D010712	1956	Chemical	Gene	START_ENTITY|dobj|stimulation stimulation|compound|END_ENTITY	Phospholipase_D2-generated phosphatidic_acid couples EGFR stimulation to Ras activation by Sos .
2830907	0	phosphatidic_acid	71,88	Epidermal_growth_factor	0,23	phosphatidic acid	Epidermal growth factor	MESH:D010712	1950	Chemical	Gene	stimulates|nmod|START_ENTITY stimulates|nsubj|END_ENTITY	Epidermal_growth_factor stimulates the incorporation of phosphate into phosphatidic_acid and phosphoinositides but does not affect phosphoinositide breakdown by phospholipase C in renal cortical slices .
19254569	0	phosphatidic_acid	58,75	LIPIN1	89,95	phosphatidic acid	LIPIN1	MESH:D010712	23175	Chemical	Gene	phosphatase|amod|START_ENTITY phosphatase|appos|END_ENTITY	TORC2 regulates hepatic insulin signaling via a mammalian phosphatidic_acid phosphatase , LIPIN1 .
21911493	0	phosphatidic_acid	75,92	LIPIN1	106,112	phosphatidic acid	LIPIN1	MESH:D010712	23175	Chemical	Gene	phosphatase|amod|START_ENTITY phosphatase|appos|END_ENTITY	Estrogen-related_receptor_y -LRB- ERRy -RRB- is a novel transcriptional regulator of phosphatidic_acid phosphatase , LIPIN1 , and inhibits hepatic insulin signaling .
17105729	0	phosphatidic_acid	79,96	lipin_1	110,117	phosphatidic acid	lipin 1	MESH:D010712	14245(Tax:10090)	Chemical	Gene	phosphatase|amod|START_ENTITY phosphatase|appos|END_ENTITY	Insulin controls subcellular localization and multisite phosphorylation of the phosphatidic_acid phosphatase , lipin_1 .
15006382	0	phosphatidic_acid	79,96	mTOR	14,18	phosphatidic acid	mTOR	MESH:D010712	21977(Tax:10090)	Chemical	Gene	analogues|nmod|START_ENTITY signaling|nmod|analogues Activation|acl|signaling Activation|nmod|END_ENTITY	Activation of mTOR signaling by novel fluoromethylene_phosphonate analogues of phosphatidic_acid .
17210675	0	phosphatidic_acid	22,39	mTOR	14,18	phosphatidic acid	mTOR	MESH:D010712	21977(Tax:10090)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of mTOR by phosphatidic_acid ?
17684489	0	phosphatidic_acid	60,77	mTOR	208,212	phosphatidic acid	mTOR	MESH:D010712	21977(Tax:10090)	Chemical	Gene	mTOR|nmod|START_ENTITY interaction|nmod|mTOR characterization|nmod|interaction characterization|dep|evidence evidence|nmod|role role|nmod|domain domain|nmod|regulation regulation|nmod|END_ENTITY	Structural characterization of the interaction of mTOR with phosphatidic_acid and a novel class of inhibitor : compelling evidence for a central role of the FRB domain in small molecule-mediated regulation of mTOR .
21510936	0	phosphatidic_acid	77,94	mTOR	62,66	phosphatidic acid	mTOR	MESH:D010712	21977(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Modulation Modulation|nmod|stress stress|nmod|activator activator|compound|END_ENTITY	Modulation of oxidative stress and tau phosphorylation by the mTOR activator phosphatidic_acid in SH-SY5Y cells .
22952117	0	phosphatidic_acid	20,37	mTOR	85,89	phosphatidic acid	mTOR	MESH:D010712	21977(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|retina retina|dep|mediator mediator|nmod|signaling signaling|compound|END_ENTITY	Diabetes diminishes phosphatidic_acid in the retina : a putative mediator for reduced mTOR signaling and increased neuronal cell death .
23077579	0	phosphatidic_acid	128,145	mTOR	120,124	phosphatidic acid	mTOR	MESH:D010712	21977(Tax:10090)	Chemical	Gene	signaling|nmod|START_ENTITY signaling|nmod|mechanism mechanism|dep|implications implications|nmod|activation activation|nmod|END_ENTITY	Mechanical stimulation induces mTOR signaling via an ERK-independent mechanism : implications for a direct activation of mTOR by phosphatidic_acid .
23077579	0	phosphatidic_acid	128,145	mTOR	31,35	phosphatidic acid	mTOR	MESH:D010712	21977(Tax:10090)	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Mechanical stimulation induces mTOR signaling via an ERK-independent mechanism : implications for a direct activation of mTOR by phosphatidic_acid .
24302719	0	phosphatidic_acid	41,58	mTOR	122,126	phosphatidic acid	mTOR	MESH:D010712	21977(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|mammalian_target_of_rapamycin mammalian_target_of_rapamycin|appos|END_ENTITY	The role of diacylglycerol kinase and phosphatidic_acid in the mechanical activation of mammalian_target_of_rapamycin -LRB- mTOR -RRB- signaling and skeletal muscle_hypertrophy .
24990952	0	phosphatidic_acid	39,56	mTOR	113,117	phosphatidic acid	mTOR	MESH:D010712	21977(Tax:10090)	Chemical	Gene	levels|amod|START_ENTITY maintenance|nmod|levels maintenance|nmod|regulation regulation|nmod|mammalian_target_of_rapamycin mammalian_target_of_rapamycin|appos|END_ENTITY	Phospholipase_D and the maintenance of phosphatidic_acid levels for regulation of mammalian_target_of_rapamycin -LRB- mTOR -RRB- .
15632115	0	phosphatidic_acid	90,107	mammalian_target_of_rapamycin	18,47	phosphatidic acid	mammalian target of rapamycin	MESH:D010712	2475	Chemical	Gene	pathway|nmod|START_ENTITY pathway|nsubj|Modulation Modulation|nmod|END_ENTITY	Modulation of the mammalian_target_of_rapamycin pathway by diacylglycerol_kinase-produced phosphatidic_acid .
24302719	0	phosphatidic_acid	41,58	mammalian_target_of_rapamycin	91,120	phosphatidic acid	mammalian target of rapamycin	MESH:D010712	2475	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	The role of diacylglycerol kinase and phosphatidic_acid in the mechanical activation of mammalian_target_of_rapamycin -LRB- mTOR -RRB- signaling and skeletal muscle_hypertrophy .
24990952	0	phosphatidic_acid	39,56	mammalian_target_of_rapamycin	82,111	phosphatidic acid	mammalian target of rapamycin	MESH:D010712	2475	Chemical	Gene	levels|amod|START_ENTITY maintenance|nmod|levels maintenance|nmod|regulation regulation|nmod|END_ENTITY	Phospholipase_D and the maintenance of phosphatidic_acid levels for regulation of mammalian_target_of_rapamycin -LRB- mTOR -RRB- .
2418997	0	phosphatidic_acid	72,89	myelin_basic_protein	15,35	phosphatidic acid	myelin basic protein	MESH:D010712	4155	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of myelin_basic_protein with different ionization states of phosphatidic_acid and phosphatidylserine .
7527658	0	phosphatidic_acid	86,103	myelin_basic_protein	60,80	phosphatidic acid	myelin basic protein	MESH:D010712	618684(Tax:9913)	Chemical	Gene	Study|nmod|START_ENTITY Study|nmod|interaction interaction|nmod|END_ENTITY	Study by infrared spectroscopy of the interaction of bovine myelin_basic_protein with phosphatidic_acid .
9032461	0	phosphatidic_acid	66,83	phospholipase_A2	45,61	phosphatidic acid	phospholipase A2	MESH:D010712	151056	Chemical	Gene	specificity|nmod|START_ENTITY specificity|nmod|END_ENTITY	High specificity of human secretory class II phospholipase_A2 for phosphatidic_acid .
9065750	0	phosphatidic_acid	52,69	phospholipase_A2	23,39	phosphatidic acid	phospholipase A2	MESH:D010712	151056	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Induction of cytosolic phospholipase_A2 activity by phosphatidic_acid and diglycerides in permeabilized human neutrophils : interrelationship between phospholipases D and A2 .
8407914	0	phosphatidic_acid	45,62	phospholipase_C-gamma_1	18,41	phosphatidic acid	phospholipase C-gamma 1	MESH:D010712	5335	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	The regulation of phospholipase_C-gamma_1 by phosphatidic_acid .
15451027	0	phosphatidic_acid	32,49	phospholipase_D	61,76	phosphatidic acid	phospholipase D	MESH:D010712	2822	Chemical	Gene	START_ENTITY|dobj|activity activity|amod|END_ENTITY	Lysophosphatidic_acid increases phosphatidic_acid formation , phospholipase_D activity and degranulation by human neutrophils .
966372	0	phosphatidyl	30,42	Renin	0,5	phosphatidyl	Renin	CHEBI:26025	24715(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|END_ENTITY	Renin inhibition by synthetic phosphatidyl and phosphorylethanolamines .
17578896	0	phosphatidyl_inositol	138,159	epidermal_growth_factor_receptor	97,129	phosphatidyl inositol	epidermal growth factor receptor	MESH:D010716	1956	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Low-dose BBR3610 toxicity in colon_cancer cells is p53-independent and enhanced by inhibition of epidermal_growth_factor_receptor -LRB- ERBB1 -RRB- - phosphatidyl_inositol 3 kinase signaling .
26617686	0	phosphatidyl_inositol	79,100	fibroblast_growth_factor_2	51,77	phosphatidyl inositol	fibroblast growth factor 2	MESH:D010716	2247	Chemical	Gene	kinase|amod|START_ENTITY kinase|amod|END_ENTITY	Expression of fibroblast_growth_factor_receptor_1 , fibroblast_growth_factor_2 , phosphatidyl_inositol 3 phosphate kinase and their clinical and prognostic significance in early and advanced stage of squamous cell carcinoma_of_the_lung .
26617686	0	phosphatidyl_inositol	79,100	fibroblast_growth_factor_receptor_1	14,49	phosphatidyl inositol	fibroblast growth factor receptor 1	MESH:D010716	2260	Chemical	Gene	kinase|amod|START_ENTITY kinase|amod|END_ENTITY	Expression of fibroblast_growth_factor_receptor_1 , fibroblast_growth_factor_2 , phosphatidyl_inositol 3 phosphate kinase and their clinical and prognostic significance in early and advanced stage of squamous cell carcinoma_of_the_lung .
6623990	0	phosphatidyl_serine	11,30	fibrinogen	48,58	phosphatidyl serine	fibrinogen	null	2244	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of phosphatidyl_serine on conversion of fibrinogen to fibrin -RSB- .
6425863	0	phosphatidylcholine	56,75	Albumin	0,7	phosphatidylcholine	Albumin	MESH:D010713	213	Chemical	Gene	stimulates|nmod|START_ENTITY stimulates|nsubj|END_ENTITY	Albumin stimulates the release of arachidonic_acid from phosphatidylcholine in hamster lungs .
15310557	0	phosphatidylcholine	25,44	C-reactive_protein	63,81	phosphatidylcholine	C-reactive protein	MESH:D010713	527553(Tax:9913)	Chemical	Gene	START_ENTITY|dobj|proteins proteins|amod|END_ENTITY	Disparate effects of two phosphatidylcholine binding proteins , C-reactive_protein and surfactant_protein_A , on pulmonary surfactant structure and function .
11108844	0	phosphatidylcholine	89,108	Cholecystokinin	0,15	phosphatidylcholine	Cholecystokinin	MESH:D010713	25298(Tax:10116)	Chemical	Gene	acini|amod|START_ENTITY labeling|nmod|acini reduce|dep|labeling reduce|nsubj|octapeptide octapeptide|compound|END_ENTITY	Cholecystokinin octapeptide CCK-8 and carbachol reduce -LSB- -LRB- 32 -RRB- P -RSB- orthophosphate labeling of phosphatidylcholine without modifying phospholipase D activity in rat pancreatic acini .
1657994	0	phosphatidylcholine	25,44	Cholecystokinin	0,15	phosphatidylcholine	Cholecystokinin	MESH:D010713	25298(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY inhibits|dobj|synthesis inhibits|nsubj|END_ENTITY	Cholecystokinin inhibits phosphatidylcholine synthesis via a Ca -LRB- 2 + -RRB- - calmodulin-dependent pathway in isolated rat pancreatic acini .
11980474	0	phosphatidylcholine	48,67	Gut2p	108,113	phosphatidylcholine	Gut2p	MESH:D010713	854651(Tax:4932)	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	Photolabeling identifies an interaction between phosphatidylcholine and glycerol-3-phosphate dehydrogenase -LRB- Gut2p -RRB- in yeast mitochondria .
8770926	0	phosphatidylcholine	45,64	Insulin	0,7	phosphatidylcholine	Insulin	MESH:D010713	3630	Chemical	Gene	hydrolysis|compound|START_ENTITY stimulates|dobj|hydrolysis stimulates|nsubj|END_ENTITY	Insulin stimulates phospholipase_D-dependent phosphatidylcholine hydrolysis , Rho translocation , de novo phospholipid synthesis , and diacylglycerol/protein _ kinase_C signaling in L6 myotubes .
2818589	0	phosphatidylcholine	25,44	Interleukin_3	0,13	phosphatidylcholine	Interleukin 3	MESH:D010713	16187(Tax:10090)	Chemical	Gene	turnover|amod|START_ENTITY stimulates|dobj|turnover stimulates|nsubj|END_ENTITY	Interleukin_3 stimulates phosphatidylcholine turnover in a mast/megakaryocyte cell line .
19215923	0	phosphatidylcholine	4,23	MCP-1	48,53	phosphatidylcholine	MCP-1	MESH:D010713	100360872	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|dobj|expression expression|amod|END_ENTITY	Soy phosphatidylcholine inhibited TLR4-mediated MCP-1 expression in vascular cells .
14757231	0	phosphatidylcholine	21,40	MRP1	116,120	phosphatidylcholine	MRP1	MESH:D010713	4363	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Fluorescent modified phosphatidylcholine floppase activity of reconstituted multidrug_resistance-associated_protein MRP1 .
16274224	0	phosphatidylcholine	38,57	PITPbeta	13,21	phosphatidylcholine	PITPbeta	MESH:D010713	114561(Tax:10116)	Chemical	Gene	complex|nmod|START_ENTITY END_ENTITY|nmod|complex	Structure of PITPbeta in complex with phosphatidylcholine : comparison of structure and lipid transfer to other PITP isoforms .
8765001	0	phosphatidylcholine	83,102	Phosphatidylcholine_transfer_protein	0,36	phosphatidylcholine	Phosphatidylcholine transfer protein	MESH:D010713	317656(Tax:9913)	Chemical	Gene	species|amod|START_ENTITY contains|dobj|species contains|nsubj|END_ENTITY	Phosphatidylcholine_transfer_protein from bovine liver contains highly unsaturated phosphatidylcholine species .
16845888	0	phosphatidylcholine	14,33	Sec14	49,54	phosphatidylcholine	Sec14	MESH:D010713	855103(Tax:4932)	Chemical	Gene	Regulation|nmod|START_ENTITY homeostasis|nsubj|Regulation homeostasis|nmod|END_ENTITY	Regulation of phosphatidylcholine homeostasis by Sec14 .
10956052	0	phosphatidylcholine	71,90	apolipoprotein_A-I	52,70	phosphatidylcholine	apolipoprotein A-I	MESH:D010713	335	Chemical	Gene	complexes|compound|START_ENTITY complexes|compound|END_ENTITY	Cholesterol efflux to high-density lipoproteins and apolipoprotein_A-I phosphatidylcholine complexes is inhibited by ethanol : role of apolipoprotein structure and cooperative interaction of phosphatidylcholine and cholesterol .
6438077	0	phosphatidylcholine	44,63	apolipoprotein_A-II	15,34	phosphatidylcholine	apolipoprotein A-II	MESH:D010713	336	Chemical	Gene	START_ENTITY|nsubj|Association Association|nmod|END_ENTITY	Association of apolipoprotein_A-II with egg phosphatidylcholine unilamellar vesicles .
1569706	0	phosphatidylcholine	45,64	cholecystokinin	26,41	phosphatidylcholine	cholecystokinin	MESH:D010713	25298(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY -LSB-|nmod|synthesis -LSB-|dobj|effect effect|nmod|END_ENTITY	-LSB- The inhibitory effect of cholecystokinin on phosphatidylcholine synthesis in isolated rat pancreatic acini -LRB- II -RRB- -RSB- .
1920900	0	phosphatidylcholine	45,64	cholecystokinin	26,41	phosphatidylcholine	cholecystokinin	MESH:D010713	25298(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY -LSB-|nmod|synthesis -LSB-|dobj|effect effect|nmod|END_ENTITY	-LSB- The inhibitory effect of cholecystokinin on phosphatidylcholine synthesis in isolated rat pancreatic acini -RSB- .
18029352	0	phosphatidylcholine	105,124	choline_kinase_alpha	63,83	phosphatidylcholine	choline kinase alpha	MESH:D010713	12660(Tax:10090)	Chemical	Gene	biosynthesis|amod|START_ENTITY enzyme|nmod|biosynthesis END_ENTITY|appos|enzyme	Early embryonic lethality caused by disruption of the gene for choline_kinase_alpha , the first enzyme in phosphatidylcholine biosynthesis .
9315860	0	phosphatidylcholine	14,33	hepatic_lipase	37,51	phosphatidylcholine	hepatic lipase	MESH:D010713	3990	Chemical	Gene	Hydrolysis|nmod|START_ENTITY Hydrolysis|nmod|END_ENTITY	Hydrolysis of phosphatidylcholine by hepatic_lipase in discoidal and spheroidal recombinant high-density lipoprotein .
3044366	0	phosphatidylcholine	99,118	insulin	11,18	phosphatidylcholine	insulin	MESH:D010713	3630	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of insulin and phorbol_esters on diacylglycerol generation and synthesis and hydrolysis of phosphatidylcholine in BC3H-1 myocytes .
3297369	0	phosphatidylcholine	62,81	insulin	16,23	phosphatidylcholine	insulin	MESH:D010713	3630	Chemical	Gene	vesicles|nmod|START_ENTITY Interactions|nmod|vesicles Interactions|nmod|END_ENTITY	Interactions of insulin with sulfatide-containing vesicles of phosphatidylcholine at different pHs .
9879668	0	phosphatidylcholine	87,106	interleukin-1beta	59,76	phosphatidylcholine	interleukin-1beta	MESH:D010713	24494(Tax:10116)	Chemical	Gene	secretion|compound|START_ENTITY secretion|amod|END_ENTITY	The inflammatory cytokines tumor_necrosis_factor_alpha and interleukin-1beta stimulate phosphatidylcholine secretion in primary cultures of rat type II pneumocytes .
19383981	0	phosphatidylcholine	16,35	lysophosphatidylcholine_acyltransferase_1	45,86	phosphatidylcholine	lysophosphatidylcholine acyltransferase 1	MESH:D010713	79888	Chemical	Gene	Biosynthesis|nmod|START_ENTITY Biosynthesis|nmod|END_ENTITY	Biosynthesis of phosphatidylcholine by human lysophosphatidylcholine_acyltransferase_1 .
25091896	0	phosphatidylcholine	21,40	paraoxonase_1	69,82	phosphatidylcholine	paraoxonase 1	MESH:D010713	5444	Chemical	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Human carotid plaque phosphatidylcholine specifically interacts with paraoxonase_1 , increases its activity , and enhances its uptake by macrophage at the expense of its binding to HDL .
10500206	0	phosphatidylcholine	86,105	phosphatidylcholine_transfer_protein	13,49	phosphatidylcholine	phosphatidylcholine transfer protein	MESH:D010713	18559(Tax:10090)	Chemical	Gene	secretion|nmod|START_ENTITY defects|nmod|secretion have|dobj|defects have|nsubj|Mice Mice|nmod|END_ENTITY	Mice without phosphatidylcholine_transfer_protein have no defects in the secretion of phosphatidylcholine into bile or into lung airspaces .
11551535	0	phosphatidylcholine	15,34	phosphatidylcholine_transfer_protein	42,78	phosphatidylcholine	phosphatidylcholine transfer protein	MESH:D010713	317656(Tax:9913)	Chemical	Gene	The|nmod|START_ENTITY The|nmod|END_ENTITY	The binding of phosphatidylcholine to the phosphatidylcholine_transfer_protein : affinity and role in folding .
3284590	0	phosphatidylcholine	28,47	phosphatidylcholine_transfer_protein	90,126	phosphatidylcholine	phosphatidylcholine transfer protein	MESH:D010713	317656(Tax:9913)	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	Effect of acceptor membrane phosphatidylcholine on the catalytic activity of bovine liver phosphatidylcholine_transfer_protein .
10395967	0	phosphatidylcholine	14,33	phospholipase_A2	69,85	phosphatidylcholine	phospholipase A2	MESH:D010713	100764593	Chemical	Gene	Regulation|nmod|START_ENTITY homeostasis|nsubj|Regulation homeostasis|nmod|END_ENTITY	Regulation of phosphatidylcholine homeostasis by calcium-independent phospholipase_A2 .
3403556	0	phosphatidylcholine	14,33	phospholipase_A2	96,112	phosphatidylcholine	phospholipase A2	MESH:D010713	151056	Chemical	Gene	Hydrolysis|nmod|START_ENTITY Hydrolysis|nmod|END_ENTITY	Hydrolysis of phosphatidylcholine in phosphatidylcholine-cholate mixtures by porcine pancreatic phospholipase_A2 .
6529700	0	phosphatidylcholine	18,37	phospholipase_A2	41,57	phosphatidylcholine	phospholipase A2	MESH:D010713	151056	Chemical	Gene	hydrolysis|nmod|START_ENTITY hydrolysis|nmod|END_ENTITY	The hydrolysis of phosphatidylcholine by phospholipase_A2 in hamster heart .
6838196	0	phosphatidylcholine	60,79	phospholipase_A2	19,35	phosphatidylcholine	phospholipase A2	MESH:D010713	151056	Chemical	Gene	hydrolysis|nmod|START_ENTITY hydrolysis|amod|END_ENTITY	Pancreatic porcine phospholipase_A2 catalyzed hydrolysis of phosphatidylcholine in lecithin-bile_salt mixed micelles : kinetic studies in a lecithin-sodium_cholate system .
12013527	0	phosphatidylcholine	38,57	platelet-activating_factor	8,34	phosphatidylcholine	platelet-activating factor	MESH:D010713	300795(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY END_ENTITY|nmod|secretion	Role of platelet-activating_factor in phosphatidylcholine secretion in primary cultures of rat type II pneumocytes .
1788877	0	phosphatidylcholine	33,52	prolactin	20,29	phosphatidylcholine	prolactin	MESH:D010713	100499538	Chemical	Gene	metabolism|amod|START_ENTITY END_ENTITY|nmod|metabolism	-LSB- Anabolic action of prolactin on phosphatidylcholine metabolism in guinea_pig adrenocorticocytes -RSB- .
2102782	0	phosphatidylcholine	23,42	prolactin	10,19	phosphatidylcholine	prolactin	MESH:D010713	100499538	Chemical	Gene	hydrolysis|amod|START_ENTITY Effect|nmod|hydrolysis Effect|nmod|END_ENTITY	Effect of prolactin on phosphatidylcholine hydrolysis via phospholipase C in isolated adrenocortical cells of guinea_pig .
23613812	0	phosphatidylcholine	45,64	stearoyl-CoA_desaturase-1	83,108	phosphatidylcholine	stearoyl-CoA desaturase-1	MESH:D010713	6319	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Human breast_cancer tissues contain abundant phosphatidylcholine -LRB- 36 1 -RRB- with high stearoyl-CoA_desaturase-1 expression .
9788244	0	phosphatidylcholine	33,52	sterol_carrier_protein_2	74,98	phosphatidylcholine	sterol carrier protein 2	MESH:D010713	508918(Tax:9913)	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Submicellar bile_salts stimulate phosphatidylcholine transfer activity of sterol_carrier_protein_2 .
7998994	0	phosphatidylcholines	112,132	ATPase	65,71	phosphatidylcholines	ATPase	MESH:D010713	1769	Chemical	Gene	reconstituted|nmod|START_ENTITY END_ENTITY|acl|reconstituted	Characterization of the single Ca -LRB- 2 + -RRB- - binding site on the Ca -LRB- 2 + -RRB- - ATPase reconstituted with short - or long-chain phosphatidylcholines .
3104334	0	phosphatidylcholines	66,86	lecithin_cholesterol_acyltransferase	92,128	phosphatidylcholines	lecithin cholesterol acyltransferase	MESH:D010713	3931	Chemical	Gene	Reaction|nmod|START_ENTITY Reaction|nmod|END_ENTITY	Reaction of discoidal complexes of apolipoprotein_A-I and various phosphatidylcholines with lecithin_cholesterol_acyltransferase .
7195282	0	phosphatidylcholines	42,62	phospholipase_A2	11,27	phosphatidylcholines	phospholipase A2	MESH:D010713	151056	Chemical	Gene	hydrolysis|nmod|START_ENTITY hydrolysis|amod|END_ENTITY	Pancreatic phospholipase_A2 hydrolysis of phosphatidylcholines in various physicochemical states .
15087306	0	phosphatidylethanol	23,42	vascular_endothelial_growth_factor	81,115	phosphatidylethanol	vascular endothelial growth factor	MESH:C051521	83785(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|concentration concentration|nmod|END_ENTITY	Lipoprotein-associated phosphatidylethanol increases the plasma concentration of vascular_endothelial_growth_factor .
22302738	0	phosphatidylethanolamine	22,46	CD300a	6,12	phosphatidylethanolamine	CD300a	MESH:C483858	11314	Chemical	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	Human CD300a binds to phosphatidylethanolamine and phosphatidylserine , and modulates the phagocytosis of dead cells .
8138721	0	phosphatidylethanolamine	27,51	phospholipase_A2	77,93	phosphatidylethanolamine	phospholipase A2	MESH:C483858	151056	Chemical	Gene	Synthesis|nmod|START_ENTITY Synthesis|nmod|END_ENTITY	Synthesis of photoreactive phosphatidylethanolamine and its interaction with phospholipase_A2 .
8171289	0	phosphatidylethanolamine	14,38	phospholipase_A2	59,75	phosphatidylethanolamine	phospholipase A2	MESH:C483858	151056	Chemical	Gene	Hydrolysis|nmod|START_ENTITY Hydrolysis|nmod|END_ENTITY	Hydrolysis of phosphatidylethanolamine by human pancreatic phospholipase_A2 .
8947502	0	phosphatidylethanolamines	11,36	ATPase	67,73	phosphatidylethanolamines	ATPase	MESH:D010714	1769	Chemical	Gene	Effects|nmod|START_ENTITY Effects|dep|END_ENTITY	Effects of phosphatidylethanolamines on the activity of the Ca -LRB- 2 + -RRB- - ATPase of sarcoplasmic reticulum .
14596606	0	phosphatidylglycerol	33,53	Alpha-synuclein	0,15	phosphatidylglycerol	Alpha-synuclein	MESH:D010715	6622	Chemical	Gene	association|nmod|START_ENTITY association|amod|END_ENTITY	Alpha-synuclein association with phosphatidylglycerol probed by lipid spin labels .
20025994	0	phosphatidylglycerol	38,58	CLS1	30,34	phosphatidylglycerol	CLS1	MESH:D010715	54675	Chemical	Gene	synthesis|amod|START_ENTITY END_ENTITY|nmod|synthesis	A novel function of the human CLS1 in phosphatidylglycerol synthesis and remodeling .
2983785	0	phosphatidylglycerol	11,31	cytochrome_P-450	64,80	phosphatidylglycerol	cytochrome P-450	MESH:D010715	4051	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of phosphatidylglycerol on the incorporation process of cytochrome_P-450 in liposomes from dimyristoylphosphatidylcholine -RSB- .
11245689	0	phosphatidylinositol	36,56	AKT	76,79	phosphatidylinositol	AKT	MESH:D010716	207	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|compound|END_ENTITY	Reduction of potassium currents and phosphatidylinositol 3-kinase-dependent AKT phosphorylation by tumor_necrosis_factor - -LRB- alpha -RRB- rescues axotomized retinal ganglion cells from retrograde cell death in vivo .
21856939	0	phosphatidylinositol	13,33	APCs	81,85	phosphatidylinositol	APCs	MESH:D010716	100517891	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	HIV-mediated phosphatidylinositol 3-kinase/serine-threonine kinase activation in APCs leads to programmed death-1 ligand upregulation and suppression of HIV-specific CD8 T cells .
15087394	0	phosphatidylinositol	96,116	Akt	27,30	phosphatidylinositol	Akt	MESH:D010716	207	Chemical	Gene	analogues|amod|START_ENTITY inhibition|nmod|analogues inhibition|nmod|END_ENTITY	Preferential inhibition of Akt and killing of Akt-dependent cancer cells by rationally designed phosphatidylinositol ether lipid analogues .
17700164	0	phosphatidylinositol	90,110	Akt	120,123	phosphatidylinositol	Akt	MESH:D010716	24185(Tax:10116)	Chemical	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Improved poststorage cardiac function by poly _ -LRB- ADP-ribose -RRB- polymerase inhibition : role of phosphatidylinositol 3-kinase Akt pathway .
6882782	0	phosphatidylinositol	26,46	Angiotensin_II	0,14	phosphatidylinositol	Angiotensin II	MESH:D010716	183	Chemical	Gene	turnover|amod|START_ENTITY stimulates|dobj|turnover stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates phosphatidylinositol turnover in adrenal glomerulosa cells by a calcium-independent mechanism .
19050071	0	phosphatidylinositol	93,113	Barkor	18,24	phosphatidylinositol	Barkor	MESH:D010716	22863	Chemical	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification of Barkor as a mammalian autophagy-specific factor for Beclin_1 and class III phosphatidylinositol 3-kinase .
15611240	0	phosphatidylinositol	49,69	Bcl-xL	34,40	phosphatidylinositol	Bcl-xL	MESH:D010716	598	Chemical	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	CD28 regulates the translation of Bcl-xL via the phosphatidylinositol 3-kinase/mammalian _ target_of_rapamycin pathway .
12902840	0	phosphatidylinositol	74,94	CA1	122,125	phosphatidylinositol	CA1	MESH:D010716	759	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Correlation between delayed neuronal cell death and selective decrease in phosphatidylinositol 4-kinase expression in the CA1 subfield of the hippocampus after transient forebrain_ischemia .
11156964	0	phosphatidylinositol	103,123	CREB	33,37	phosphatidylinositol	CREB	MESH:D010716	81646(Tax:10116)	Chemical	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway .
22021906	0	phosphatidylinositol	38,58	Cdk7	14,18	phosphatidylinositol	Cdk7	MESH:D010716	1022	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Regulation of Cdk7 activity through a phosphatidylinositol -LRB- 3 -RRB- - kinase/PKC - - mediated signaling cascade in glioblastoma .
16627469	0	phosphatidylinositol	69,89	Eg5	34,37	phosphatidylinositol	Eg5	MESH:D010716	3832	Chemical	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	Inhibition of the mitotic kinesin Eg5 up-regulates Hsp70 through the phosphatidylinositol 3-kinase/Akt pathway in multiple_myeloma cells .
10554021	0	phosphatidylinositol	83,103	Epidermal_growth_factor	0,23	phosphatidylinositol	Epidermal growth factor	MESH:D010716	1950	Chemical	Gene	3|amod|START_ENTITY promotes|nmod|3 promotes|nsubj|END_ENTITY	Epidermal_growth_factor promotes MDA-MB-231_breast_cancer cell migration through a phosphatidylinositol 3 ' - kinase and phospholipase C-dependent mechanism .
15802268	0	phosphatidylinositol	139,159	Epidermal_growth_factor	0,23	phosphatidylinositol	Epidermal growth factor	MESH:D010716	1950	Chemical	Gene	mammalian_target_of_rapamycin|amod|START_ENTITY regulated|nmod|mammalian_target_of_rapamycin regulated|nsubjpass|expression expression|compound|END_ENTITY	Epidermal_growth_factor and hypoxia-induced expression of CXC_chemokine_receptor_4 on non-small_cell_lung_cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT / mammalian_target_of_rapamycin signaling pathway and activation of hypoxia_inducible_factor-1alpha .
16766857	0	phosphatidylinositol	61,81	Epidermal_growth_factor	0,23	phosphatidylinositol	Epidermal growth factor	MESH:D010716	25313(Tax:10116)	Chemical	Gene	pathway|amod|START_ENTITY induces|nmod|pathway induces|nsubj|END_ENTITY	Epidermal_growth_factor induces vasoconstriction through the phosphatidylinositol 3-kinase-mediated mitogen-activated protein kinase pathway in hypertensive rats .
2625434	0	phosphatidylinositol	170,190	Epidermal_growth_factor	0,23	phosphatidylinositol	Epidermal growth factor	MESH:D010716	1950	Chemical	Gene	turnover|amod|START_ENTITY stimulates|dobj|turnover stimulates|dep|stimulates stimulates|nsubj|END_ENTITY	Epidermal_growth_factor stimulates phosphatidylinositol turnover in human foreskin fibroblasts without activation of protein kinase C. Epidermal_growth_factor stimulates phosphatidylinositol turnover in human foreskin fibroblasts .
2625434	0	phosphatidylinositol	35,55	Epidermal_growth_factor	0,23	phosphatidylinositol	Epidermal growth factor	MESH:D010716	1950	Chemical	Gene	turnover|amod|START_ENTITY stimulates|dobj|turnover stimulates|nsubj|END_ENTITY	Epidermal_growth_factor stimulates phosphatidylinositol turnover in human foreskin fibroblasts without activation of protein kinase C. Epidermal_growth_factor stimulates phosphatidylinositol turnover in human foreskin fibroblasts .
3262342	0	phosphatidylinositol	168,188	Epidermal_growth_factor	0,23	phosphatidylinositol	Epidermal growth factor	MESH:D010716	1950	Chemical	Gene	turnover|amod|START_ENTITY stimulated|dobj|turnover Epidermal_Growth_Factor|acl|stimulated activation|nmod|Epidermal_Growth_Factor stimulates|nmod|activation stimulates|nsubj|END_ENTITY	Epidermal_growth_factor stimulates phosphatidylinositol turnover for ten hours in A431 cells without activation of protein kinase C. Epidermal_Growth_Factor stimulated phosphatidylinositol turnover in A431 cells for up to ten hours .
3262342	0	phosphatidylinositol	35,55	Epidermal_growth_factor	0,23	phosphatidylinositol	Epidermal growth factor	MESH:D010716	1950	Chemical	Gene	turnover|amod|START_ENTITY stimulates|dobj|turnover stimulates|nsubj|END_ENTITY	Epidermal_growth_factor stimulates phosphatidylinositol turnover for ten hours in A431 cells without activation of protein kinase C. Epidermal_Growth_Factor stimulated phosphatidylinositol turnover in A431 cells for up to ten hours .
8123595	0	phosphatidylinositol	104,124	Epidermal_growth_factor	0,23	phosphatidylinositol	Epidermal growth factor	MESH:D010716	1950	Chemical	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Epidermal_growth_factor induces the production of biologically distinguishable diglyceride species from phosphatidylinositol and phosphatidylcholine via the independent activation of type C and type D phospholipases .
9950886	0	phosphatidylinositol	36,56	ErbB-2	14,20	phosphatidylinositol	ErbB-2	MESH:D010716	2064	Chemical	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	EGF activates ErbB-2 and stimulates phosphatidylinositol 3-kinase in human airway smooth muscle cells .
2735929	0	phosphatidylinositol	82,102	F11	33,36	phosphatidylinositol	F11	MESH:D010716	422723(Tax:9031)	Chemical	Gene	interaction|nmod|START_ENTITY END_ENTITY|dep|interaction	Neural cell recognition molecule F11 : membrane interaction by covalently attached phosphatidylinositol .
12960025	0	phosphatidylinositol	104,124	FoxO1a	93,99	phosphatidylinositol	FoxO1a	MESH:D010716	2308	Chemical	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	Follicle-stimulating hormone promotes nuclear exclusion of the forkhead transcription factor FoxO1a via phosphatidylinositol 3-kinase in porcine granulosa cells .
14597408	0	phosphatidylinositol	110,130	GATA-4	100,106	phosphatidylinositol	GATA-4	MESH:D010716	14463(Tax:10090)	Chemical	Gene	inhibitor|amod|START_ENTITY END_ENTITY|nmod|inhibitor	Early stage-specific inhibitions of cardiomyocyte differentiation and expression of Csx/Nkx -2.5 and GATA-4 by phosphatidylinositol 3-kinase inhibitor LY294002 .
12869574	0	phosphatidylinositol	53,73	GLUT1	134,139	phosphatidylinositol	GLUT1	MESH:D010716	20525(Tax:10090)	Chemical	Gene	translocation|amod|START_ENTITY translocation|nmod|END_ENTITY	Interleukin-3-mediated cell survival signals include phosphatidylinositol 3-kinase-dependent translocation of the glucose transporter GLUT1 to the cell surface .
6140852	0	phosphatidylinositol	32,52	GRF	17,20	phosphatidylinositol	GRF	MESH:D010716	2691	Chemical	Gene	START_ENTITY|nsubj|stimulates stimulates|compound|END_ENTITY	Human pancreatic GRF stimulates phosphatidylinositol labeling in cultured anterior pituitary cells .
6340112	0	phosphatidylinositol	49,69	Gonadotropin-releasing_hormone	0,30	phosphatidylinositol	Gonadotropin-releasing hormone	MESH:D010716	25194(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY stimulates|dobj|metabolism stimulates|nsubj|END_ENTITY	Gonadotropin-releasing_hormone -LRB- GnRH -RRB- stimulates phosphatidylinositol metabolism in rat granulosa cells : mechanism of action of GnRH .
7772238	0	phosphatidylinositol	53,73	Growth_hormone_releasing_peptide	0,32	phosphatidylinositol	Growth hormone releasing peptide	MESH:D010716	51738	Chemical	Gene	turnover|amod|START_ENTITY stimulates|dobj|turnover stimulates|nsubj|END_ENTITY	Growth_hormone_releasing_peptide -LRB- GHRP-6 -RRB- stimulates phosphatidylinositol -LRB- PI -RRB- turnover in human pituitary somatotroph cells .
12800089	3	phosphatidylinositol	671,691	IRS-1	639,644	phosphatidylinositol	IRS-1	MESH:D010716	3667	Chemical	Gene	activity|dep|START_ENTITY activity|amod|END_ENTITY	L6 skeletal muscle cells -LRB- L6 cells -RRB- were treated with inhibitors of protein-tyrosine phosphatases , proteasomal degradation , and mammalian_target_of_rapamycin -LRB- mTOR -RRB- , and the effects of insulin on glucose uptake , IRS-1 tyrosine phosphorylation , phosphatidylinositol -LRB- PI -RRB- 3-kinase activity , and IRS-1 mass were examined .
17785853	0	phosphatidylinositol	15,35	I_kappa_B_alpha	71,86	phosphatidylinositol	I kappa B alpha	MESH:D010716	18035(Tax:10090)	Chemical	Gene	up-regulation|amod|START_ENTITY up-regulation|nmod|END_ENTITY	Involvement of phosphatidylinositol 3-kinase-mediated up-regulation of I_kappa_B_alpha in anti-inflammatory effect of gemfibrozil in microglia .
6432603	0	phosphatidylinositol	24,44	LHRH	0,4	phosphatidylinositol	LHRH	MESH:D010716	2796	Chemical	Gene	metabolism|amod|START_ENTITY stimulates|dobj|metabolism stimulates|nsubj|END_ENTITY	LHRH rapidly stimulates phosphatidylinositol metabolism in enriched gonadotrophs .
23097495	0	phosphatidylinositol	45,65	LPIAT1	0,6	phosphatidylinositol	LPIAT1	MESH:D010716	77582(Tax:10090)	Chemical	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	LPIAT1 regulates arachidonic_acid content in phosphatidylinositol and is required for cortical lamination in mice .
15297252	0	phosphatidylinositol	66,86	MT1-MMP	120,127	phosphatidylinositol	MT1-MMP	MESH:D010716	4323	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Activation of MMP-2 in response to vascular_injury is mediated by phosphatidylinositol 3-kinase-dependent expression of MT1-MMP .
20522663	0	phosphatidylinositol	135,155	P-glycoprotein	8,22	phosphatidylinositol	P-glycoprotein	MESH:D010716	67078(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of P-glycoprotein and breast_cancer_resistance_protein-1 in the brain penetration and brain pharmacodynamic activity of the novel phosphatidylinositol 3-kinase inhibitor GDC-0941 .
12738763	0	phosphatidylinositol	172,192	PDK1	234,238	phosphatidylinositol	PDK1	MESH:D010716	5163	Chemical	Gene	pathway|amod|START_ENTITY pathway|nmod|END_ENTITY	RET/PTC -LRB- rearranged_in_transformation / papillary_thyroid_carcinomas -RRB- tyrosine kinase phosphorylates and activates phosphoinositide-dependent_kinase_1 -LRB- PDK1 -RRB- : an alternative phosphatidylinositol 3-kinase-independent pathway to activate PDK1 .
23028960	0	phosphatidylinositol	82,102	PI3KC2b	118,125	phosphatidylinositol	PI3KC2b	MESH:D010716	5287	Chemical	Gene	regulation|amod|START_ENTITY regulation|appos|END_ENTITY	A new dimension to Ras function : a novel role for nucleotide-free Ras in Class II phosphatidylinositol 3-kinase beta -LRB- PI3KC2b -RRB- regulation .
11170653	0	phosphatidylinositol	67,87	PI4K230	106,113	phosphatidylinositol	PI4K230	MESH:D010716	5297	Chemical	Gene	isoform|amod|START_ENTITY isoform|appos|END_ENTITY	Synthesis of new cyclitol compounds that influence the activity of phosphatidylinositol 4-kinase isoform , PI4K230 .
7914867	0	phosphatidylinositol	40,60	PITPN	79,84	phosphatidylinositol	PITPN	MESH:D010716	5306	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Localization of the gene encoding human phosphatidylinositol transfer protein -LRB- PITPN -RRB- to 17p13 .3 : a gene showing homology to the Drosophila retinal_degeneration_B gene -LRB- rdgB -RRB- .
12477731	0	phosphatidylinositol	58,78	Pik1	97,101	phosphatidylinositol	Pik1	MESH:D010716	855454(Tax:4932)	Chemical	Gene	isoform|amod|START_ENTITY isoform|appos|END_ENTITY	Molecular interactions of yeast frequenin -LRB- Frq1 -RRB- with the phosphatidylinositol 4-kinase isoform , Pik1 .
14512421	0	phosphatidylinositol	144,164	Pik1	183,187	phosphatidylinositol	Pik1	MESH:D010716	855454(Tax:4932)	Chemical	Gene	isoform|amod|START_ENTITY isoform|appos|END_ENTITY	Conservation of regulatory function in calcium-binding proteins : human frequenin -LRB- neuronal_calcium_sensor-1 -RRB- associates productively with yeast phosphatidylinositol 4-kinase isoform , Pik1 .
15928809	0	phosphatidylinositol	64,84	Rac1	100,104	phosphatidylinositol	Rac1	MESH:D010716	5879	Chemical	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Emodin inhibits tumor cell migration through suppression of the phosphatidylinositol 3-kinase-Cdc42 / Rac1 pathway .
17135240	0	phosphatidylinositol	72,92	Rac1	112,116	phosphatidylinositol	Rac1	MESH:D010716	5879	Chemical	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Regulation of EphA2 receptor endocytosis by SHIP2 lipid phosphatase via phosphatidylinositol 3-Kinase-dependent Rac1 activation .
18056353	0	phosphatidylinositol	93,113	Rac1	147,151	phosphatidylinositol	Rac1	MESH:D010716	5879	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Formyl_peptide_receptor-1 activation enhances intestinal epithelial cell restitution through phosphatidylinositol 3-kinase-dependent activation of Rac1 and Cdc42 .
16973905	0	phosphatidylinositol	38,58	SHIP2	116,121	phosphatidylinositol	SHIP2	MESH:D010716	3636	Chemical	Gene	Pathway|amod|START_ENTITY Pathway|nmod|END_ENTITY	APOE4-VLDL inhibits the HDL-activated phosphatidylinositol 3-kinase/Akt Pathway via the phosphoinositol phosphatase SHIP2 .
15590660	0	phosphatidylinositol	86,106	STAT3	145,150	phosphatidylinositol	STAT3	MESH:D010716	6774	Chemical	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Carbon_monoxide differentially modulates STAT1 and STAT3 and inhibits apoptosis via a phosphatidylinositol 3-kinase/Akt and p38 kinase-dependent STAT3 pathway during anoxia-reoxygenation injury .
19139096	0	phosphatidylinositol	118,138	Sac1p	90,95	phosphatidylinositol	Sac1p	MESH:D010716	853668(Tax:4932)	Chemical	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Modulation of sphingolipid metabolism by the phosphatidylinositol-4-phosphate phosphatase Sac1p through regulation of phosphatidylinositol in Saccharomyces_cerevisiae .
11369518	1	phosphatidylinositol	124,144	Src	155,158	phosphatidylinositol	Src	MESH:D010716	6714	Chemical	Gene	kinase|amod|START_ENTITY kinase|amod|END_ENTITY	Role of Grb2 , phosphatidylinositol 3-kinase , Src tyrosine kinase , and phospholipase Cgamma .
18178826	0	phosphatidylinositol	42,62	Syk	0,3	phosphatidylinositol	Syk	MESH:D010716	6850	Chemical	Gene	START_ENTITY|nsubj|associates associates|compound|END_ENTITY	Syk associates with clathrin and mediates phosphatidylinositol 3-kinase activation during human rhinovirus internalization .
18565131	0	phosphatidylinositol	47,67	Thrombin	0,8	phosphatidylinositol	Thrombin	MESH:D010716	2147	Chemical	Gene	synthesis|nmod|START_ENTITY induces|dobj|synthesis induces|nsubj|END_ENTITY	Thrombin induces osteoprotegerin synthesis via phosphatidylinositol 3 ' - kinase/mammalian _ target_of_rapamycin pathway in human periodontal ligament cells .
14530393	0	phosphatidylinositol	78,98	Y_box-binding_protein_1	0,23	phosphatidylinositol	Y box-binding protein 1	MESH:D010716	386575(Tax:9031)	Chemical	Gene	pathway|amod|START_ENTITY induces|nmod|pathway induces|nsubj|END_ENTITY	Y_box-binding_protein_1 induces resistance to oncogenic transformation by the phosphatidylinositol 3-kinase pathway .
10350622	0	phosphatidylinositol	43,63	acetylcholinesterase	86,106	phosphatidylinositol	acetylcholinesterase	MESH:D010716	43	Chemical	Gene	modification|amod|START_ENTITY modification|nmod|END_ENTITY	Optimising the signal peptide for glycosyl phosphatidylinositol modification of human acetylcholinesterase using mutational analysis and peptide-quantitative structure-activity relationships .
9892008	0	phosphatidylinositol	97,117	alpha1A	34,41	phosphatidylinositol	alpha1A	MESH:D010716	12286(Tax:10090)	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Contrasting signaling pathways of alpha1A - and alpha1B-adrenergic_receptor subtype activation of phosphatidylinositol 3-kinase and Ras in transfected NIH3T3 cells .
15684402	0	phosphatidylinositol	82,102	apolipoprotein_A5	36,53	phosphatidylinositol	apolipoprotein A5	MESH:D010716	116519	Chemical	Gene	pathway|amod|START_ENTITY expression|nmod|pathway expression|amod|END_ENTITY	Insulin-mediated down-regulation of apolipoprotein_A5 gene expression through the phosphatidylinositol 3-kinase pathway : role of upstream stimulatory factor .
1734875	0	phosphatidylinositol	24,44	c-myc	48,53	phosphatidylinositol	c-myc	MESH:D010716	4609	Chemical	Gene	START_ENTITY|nmod|line line|amod|END_ENTITY	Effect of extracellular phosphatidylinositol on c-myc gene-expressed human renal_cancer cell line .
11509654	0	phosphatidylinositol	78,98	cyclin-dependent_kinase_2	132,157	phosphatidylinositol	cyclin-dependent kinase 2	MESH:D010716	12566(Tax:10090)	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Dna damage-induced G -LRB- 1 -RRB- arrest in hematopoietic cells is overridden following phosphatidylinositol 3-kinase-dependent activation of cyclin-dependent_kinase_2 .
18435486	0	phosphatidylinositol	122,142	endothelial_nitric-oxide_synthase	80,113	phosphatidylinositol	endothelial nitric-oxide synthase	MESH:D010716	4846	Chemical	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	Tannin_1-alpha-O-galloylpunicalagin induces the calcium-dependent activation of endothelial_nitric-oxide_synthase via the phosphatidylinositol 3-kinase/Akt pathway in endothelial cells .
14716823	0	phosphatidylinositol	84,104	epidermal_growth_factor	56,79	phosphatidylinositol	epidermal growth factor	MESH:D010716	1950	Chemical	Gene	3-kinase|amod|START_ENTITY Enhancement|nmod|3-kinase Enhancement|nmod|END_ENTITY	Enhancement of osteopontin expression in HepG2 cells by epidermal_growth_factor via phosphatidylinositol 3-kinase signaling pathway .
2549060	0	phosphatidylinositol	101,121	epidermal_growth_factor	29,52	phosphatidylinositol	epidermal growth factor	MESH:D010716	1950	Chemical	Gene	turnover|amod|START_ENTITY desensitization|nmod|turnover induces|dobj|desensitization induces|nsubj|Treatment Treatment|nmod|cells cells|nmod|END_ENTITY	Treatment of A431 cells with epidermal_growth_factor -LRB- EGF -RRB- induces desensitization of EGF-stimulated phosphatidylinositol turnover .
8626628	0	phosphatidylinositol	13,33	epidermal_growth_factor	52,75	phosphatidylinositol	epidermal growth factor	MESH:D010716	1950	Chemical	Gene	START_ENTITY|dobj|stimulation stimulation|compound|END_ENTITY	Brush border phosphatidylinositol 3-kinase mediates epidermal_growth_factor stimulation of intestinal NaCl absorption and Na + / H + exchange .
8943699	0	phosphatidylinositol	37,57	epidermal_growth_factor	10,33	phosphatidylinositol	epidermal growth factor	MESH:D010716	100008808(Tax:9986)	Chemical	Gene	activity|amod|START_ENTITY Effect|nmod|activity Effect|nmod|END_ENTITY	Effect of epidermal_growth_factor on phosphatidylinositol 3-kinase activity in rabbit corneal epithelial cells .
9886492	0	phosphatidylinositol	53,73	epidermal_growth_factor	112,135	phosphatidylinositol	epidermal growth factor	MESH:D010716	1950	Chemical	Gene	activity|amod|START_ENTITY involving|dobj|activity involving|nmod|stimulation stimulation|nmod|factor-I factor-I|compound|END_ENTITY	Formation of distinct signalling complexes involving phosphatidylinositol 3-kinase activity with stimulation of epidermal_growth_factor or insulin-like growth factor-I in human skin fibroblasts .
17138652	0	phosphatidylinositol	110,130	epidermal_growth_factor_receptor_2	75,109	phosphatidylinositol	epidermal growth factor receptor 2	MESH:D010716	2064	Chemical	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	The effect of estradiol on in vivo tumorigenesis is modulated by the human epidermal_growth_factor_receptor_2 / phosphatidylinositol 3-kinase/Akt1 pathway .
10400703	0	phosphatidylinositol	99,119	focal_adhesion_kinase	23,44	phosphatidylinositol	focal adhesion kinase	MESH:D010716	14083(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|interactions interactions|nmod|END_ENTITY	PTEN interactions with focal_adhesion_kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway .
8603102	0	phosphatidylinositol	15,35	focal_adhesion_kinase	79,100	phosphatidylinositol	focal adhesion kinase	MESH:D010716	14083(Tax:10090)	Chemical	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of phosphatidylinositol 3-kinase , via the SH2 domains of p85 , with focal_adhesion_kinase in polyoma middle t-transformed fibroblasts .
14612449	0	phosphatidylinositol	137,157	glucokinase	101,112	phosphatidylinositol	glucokinase	MESH:D010716	24385(Tax:10116)	Chemical	Gene	pathway|amod|START_ENTITY expression|nmod|pathway expression|amod|END_ENTITY	The transcription factors HIF-1 and HNF-4 and the coactivator p300 are involved in insulin-regulated glucokinase gene expression via the phosphatidylinositol 3-kinase/protein kinase B pathway .
16704410	0	phosphatidylinositol	45,65	heme_oxygenase-1	16,32	phosphatidylinositol	heme oxygenase-1	MESH:D010716	15368(Tax:10090)	Chemical	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	Insulin induces heme_oxygenase-1 through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in renal cells .
9388585	0	phosphatidylinositol	26,46	insulin	68,75	phosphatidylinositol	insulin	MESH:D010716	3630	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Is stimulation of class-1 phosphatidylinositol 3-kinase activity by insulin sufficient to activate pathways involved in glucose metabolism .
9421369	0	phosphatidylinositol	63,83	insulin_receptor_substrates_1_and_2	108,143	phosphatidylinositol	insulin receptor substrates 1 and 2	MESH:D010716	25467;29376	Chemical	Gene	START_ENTITY|dobj|activation activation|nmod|END_ENTITY	Altered expression levels and impaired steps in the pathway to phosphatidylinositol 3-kinase activation via insulin_receptor_substrates_1_and_2 in Zucker fatty rats .
17121804	0	phosphatidylinositol	65,85	interleukin-8	21,34	phosphatidylinositol	interleukin-8	MESH:D010716	3576	Chemical	Gene	pathway|amod|START_ENTITY expression|nmod|pathway expression|amod|END_ENTITY	Rhinovirus activates interleukin-8 expression via a Src/p110beta phosphatidylinositol 3-kinase/Akt pathway in human airway epithelial cells .
19321861	0	phosphatidylinositol	115,135	mammalian_target_of_rapamycin	155,184	phosphatidylinositol	mammalian target of rapamycin	MESH:D010716	2475	Chemical	Gene	activation|amod|START_ENTITY activation|compound|END_ENTITY	A_proliferation-inducing_ligand mediates follicular_lymphoma B-cell proliferation and cyclin_D1 expression through phosphatidylinositol 3-kinase-regulated mammalian_target_of_rapamycin activation .
18094042	0	phosphatidylinositol	137,157	mboa-7	23,29	phosphatidylinositol	mboa-7	MESH:D010716	181252(Tax:6239)	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Caenorhabditis_elegans mboa-7 , a member of the MBOAT family , is required for selective incorporation of polyunsaturated_fatty_acids into phosphatidylinositol .
19881225	0	phosphatidylinositol	136,156	nuclear_factor-kappaB	172,193	phosphatidylinositol	nuclear factor-kappaB	MESH:D010716	4790	Chemical	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	Proteinase-activated_receptor-2-triggered prostaglandin_E -LRB- 2 -RRB- release , but not cyclooxygenase-2 upregulation , requires activation of the phosphatidylinositol 3-kinase/Akt / nuclear_factor-kappaB pathway in human alveolar epithelial cells .
15705860	0	phosphatidylinositol	44,64	osteopontin	24,35	phosphatidylinositol	osteopontin	MESH:D010716	6696	Chemical	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	Hyaluronic acid induces osteopontin via the phosphatidylinositol 3-kinase/Akt pathway to enhance the motility of human glioma cells .
18565131	0	phosphatidylinositol	47,67	osteoprotegerin	17,32	phosphatidylinositol	osteoprotegerin	MESH:D010716	4982	Chemical	Gene	synthesis|nmod|START_ENTITY synthesis|compound|END_ENTITY	Thrombin induces osteoprotegerin synthesis via phosphatidylinositol 3 ' - kinase/mammalian _ target_of_rapamycin pathway in human periodontal ligament cells .
16339315	0	phosphatidylinositol	58,78	p110alpha	35,44	phosphatidylinositol	p110alpha	MESH:D010716	5290	Chemical	Gene	START_ENTITY|nsubj|properties properties|nmod|END_ENTITY	The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells .
19074847	0	phosphatidylinositol	40,60	p55PIK	33,39	phosphatidylinositol	p55PIK	MESH:D010716	8503	Chemical	Gene	subunit|amod|START_ENTITY subunit|amod|END_ENTITY	A peptide inhibitor derived from p55PIK phosphatidylinositol 3-kinase regulatory subunit : a novel cancer therapy .
10967104	0	phosphatidylinositol	146,166	p85	131,134	phosphatidylinositol	p85	MESH:D010716	5296	Chemical	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	Using a phage display library to identify basic residues in A-Raf required to mediate binding to the Src homology 2 domains of the p85 subunit of phosphatidylinositol 3 ' - kinase .
15377662	0	phosphatidylinositol	24,44	p85alpha	4,12	phosphatidylinositol	p85alpha	MESH:D010716	5295	Chemical	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	The p85alpha subunit of phosphatidylinositol 3 ' - kinase binds to and stimulates the GTPase activity of Rab proteins .
9582025	0	phosphatidylinositol	35,55	p85beta	65,72	phosphatidylinositol	p85beta	MESH:D010716	5296	Chemical	Gene	subunit|amod|START_ENTITY subunit|amod|END_ENTITY	An oncogenic fusion product of the phosphatidylinositol 3-kinase p85beta subunit and HUMORF8 , a putative deubiquitinating enzyme .
15470065	0	phosphatidylinositol	140,160	peroxisome_proliferator-activated_receptor_gamma	212,260	phosphatidylinositol	peroxisome proliferator-activated receptor gamma	MESH:D010716	25664(Tax:10116)	Chemical	Gene	independent|amod|START_ENTITY independent|nmod|END_ENTITY	The 15-deoxy-delta12 ,14 - prostaglandin_J2 inhibits the inflammatory response in primary rat astrocytes via down-regulating multiple steps in phosphatidylinositol 3-kinase-Akt-NF-kappaB-p300 pathway independent of peroxisome_proliferator-activated_receptor_gamma .
2305210	0	phosphatidylinositol	14,34	phospholipase_A2	55,71	phosphatidylinositol	phospholipase A2	MESH:D010716	151056	Chemical	Gene	Hydrolysis|nmod|START_ENTITY Hydrolysis|nmod|END_ENTITY	Hydrolysis of phosphatidylinositol by human pancreatic phospholipase_A2 .
8108463	0	phosphatidylinositol	47,67	prolactin	14,23	phosphatidylinositol	prolactin	MESH:D010716	5617	Chemical	Gene	kinase|amod|START_ENTITY END_ENTITY|nmod|kinase	Inhibition by prolactin of membrane-associated phosphatidylinositol kinase of human endometrial fibroblast .
11108839	0	phosphatidylinositol	38,58	protein_kinase_B	93,109	phosphatidylinositol	protein kinase B	MESH:D010716	2185	Chemical	Gene	kinases|amod|START_ENTITY kinases|amod|END_ENTITY	The T cell antigen receptor activates phosphatidylinositol 3-kinase-regulated serine kinases protein_kinase_B and ribosomal_S6_kinase_1 .
10531358	0	phosphatidylinositol	46,66	rdgBbeta	85,93	phosphatidylinositol	rdgBbeta	MESH:D010716	26207	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Cloning and characterization of a novel human phosphatidylinositol transfer protein , rdgBbeta .
1400434	0	phosphatidylinositol	53,73	surfactant_protein_D	10,30	phosphatidylinositol	surfactant protein D	MESH:D010716	6441	Chemical	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	Pulmonary surfactant_protein_D specifically binds to phosphatidylinositol .
1905965	0	phosphatidylinositol	29,49	thrombin	69,77	phosphatidylinositol	thrombin	MESH:D010716	2147	Chemical	Gene	turnover|amod|START_ENTITY Effects|nmod|turnover Effects|nmod|stimulation stimulation|compound|END_ENTITY	Effects of chlorpromazine on phosphatidylinositol turnover following thrombin stimulation of human platelets .
2999166	0	phosphatidylinositol	105,125	thrombin	139,147	phosphatidylinositol	thrombin	MESH:D010716	2147	Chemical	Gene	synthesis|amod|START_ENTITY synthesis|nmod|END_ENTITY	Effects of EGF and thrombin on inositol-containing phospholipids of cultured fibroblasts : stimulation of phosphatidylinositol synthesis by thrombin but not EGF .
14576166	0	phosphatidylinositol	31,51	transforming_growth_factor-beta1	76,108	phosphatidylinositol	transforming growth factor-beta1	MESH:D010716	7040	Chemical	Gene	pathway|amod|START_ENTITY pathway|nmod|END_ENTITY	Activation of the pro-survival phosphatidylinositol 3-kinase/AKT pathway by transforming_growth_factor-beta1 in mesenchymal cells is mediated by p38 MAPK-dependent induction of an autocrine growth factor .
16543245	0	phosphatidylinositol	82,102	vascular_endothelial_growth_factor	22,56	phosphatidylinositol	vascular endothelial growth factor	MESH:D010716	7422	Chemical	Gene	induction|nmod|START_ENTITY END_ENTITY|nmod|induction	Hypoxic regulation of vascular_endothelial_growth_factor through the induction of phosphatidylinositol 3-kinase/Rho/ROCK and c-Myc .
23193159	0	phosphatidylinositol-5-phosphate	14,46	Pin1	60,64	phosphatidylinositol-5-phosphate	Pin1	MESH:C113567	23988(Tax:10090)	Chemical	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Regulation of phosphatidylinositol-5-phosphate signaling by Pin1 determines sensitivity to oxidative stress .
11950935	0	phosphatidylinositol_3-phosphate	19,51	Fab1	14,18	phosphatidylinositol 3-phosphate	Fab1	MESH:C055525	850574(Tax:4932)	Chemical	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	Regulation of Fab1 phosphatidylinositol_3-phosphate 5-kinase pathway by Vac7 protein and Fig4 , a polyphosphoinositide phosphatase family member .
18434594	0	phosphatidylinositol_3-phosphate	19,51	Insulin	0,7	phosphatidylinositol 3-phosphate	Insulin	MESH:C055525	3630	Chemical	Gene	production|amod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Insulin stimulates phosphatidylinositol_3-phosphate production via the activation of Rab5 .
24867506	0	phosphatidylinositol_3-phosphate	71,103	insulin	14,21	phosphatidylinositol 3-phosphate	insulin	MESH:C055525	3630	Chemical	Gene	kinase|amod|START_ENTITY involvement|nmod|kinase Regulation|dep|involvement Regulation|nmod|secretion secretion|compound|END_ENTITY	Regulation of insulin secretion by geniposide : possible involvement of phosphatidylinositol_3-phosphate kinase .
22553352	0	phosphatidylinositol_4-phosphate	17,49	Vps74	86,91	phosphatidylinositol 4-phosphate	Vps74	MESH:C037178	64083	Chemical	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Local control of phosphatidylinositol_4-phosphate signaling in the Golgi apparatus by Vps74 and Sac1 phosphoinositide phosphatase .
16982895	0	phosphatidylinositol_mannoside	45,75	CD1d	93,97	phosphatidylinositol mannoside	CD1d	MESH:C034154	12479(Tax:10090)	Chemical	Gene	START_ENTITY|xcomp|binding binding|nmod|END_ENTITY	Structural characterization of mycobacterial phosphatidylinositol_mannoside binding to mouse CD1d .
2433285	0	phosphatidylinositol_monophosphate	53,87	Epidermal_growth_factor	0,23	phosphatidylinositol monophosphate	Epidermal growth factor	CHEBI:26036	1950	Chemical	Gene	production|nmod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Epidermal_growth_factor stimulates the production of phosphatidylinositol_monophosphate and the breakdown of polyphosphoinositides in A431 cells .
17220200	0	phosphatidylinositol_monophosphate	23,57	PIP5K9	0,6	phosphatidylinositol monophosphate	PIP5K9	CHEBI:26036	820151(Tax:3702)	Chemical	Gene	kinase|compound|START_ENTITY END_ENTITY|appos|kinase	PIP5K9 , an Arabidopsis phosphatidylinositol_monophosphate kinase , interacts with a cytosolic invertase to negatively regulate sugar-mediated root growth .
11672432	0	phosphatidylinositol_phosphate	34,64	AtPIP5K1	0,8	phosphatidylinositol phosphate	AtPIP5K1	CHEBI:28765	838801(Tax:3702)	Chemical	Gene	kinase|compound|START_ENTITY END_ENTITY|appos|kinase	AtPIP5K1 , an Arabidopsis_thaliana phosphatidylinositol_phosphate kinase , synthesizes PtdIns -LRB- 3,4 -RRB- P -LRB- 2 -RRB- and PtdIns -LRB- 4,5 -RRB- P -LRB- 2 -RRB- in vitro and is inhibited by phosphorylation .
14710196	0	phosphatidylinositol_phosphates	49,80	CFTR	41,45	phosphatidylinositol phosphates	CFTR	MESH:D018129	1080	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Protein_kinase-independent activation of CFTR by phosphatidylinositol_phosphates .
12504005	0	phosphatidylinosotol	31,51	c-myc	108,113	phosphatidylinosotol	c-myc	null	4609	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|transcription transcription|amod|END_ENTITY	B cell growth is controlled by phosphatidylinosotol 3-kinase-dependent induction of Rel/NF-kappaB regulated c-myc transcription .
2914139	0	phosphatidylserine	123,141	Aminophospholipid_translocase	0,29	phosphatidylserine	Aminophospholipid translocase	null	54670(Tax:10090)	Chemical	Gene	induce|nmod|START_ENTITY induce|nsubj|END_ENTITY	Aminophospholipid_translocase in the plasma membrane of Friend erythroleukemic cells can induce an asymmetric topology for phosphatidylserine but not for phosphatidylethanolamine .
2949778	0	phosphatidylserine	56,74	Calcium_binding_protein	0,23	phosphatidylserine	Calcium binding protein	null	1068	Chemical	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	Calcium_binding_protein from porcine intestine binds to phosphatidylserine vesicles in the presence of calcium .
8276751	2	phosphatidylserine	344,362	MARCKS	315,321	phosphatidylserine	MARCKS	null	81520(Tax:10116)	Chemical	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	MARCKS specifically binds to phosphatidylserine but not phosphatidylcholine .
12071854	0	phosphatidylserine	13,31	P-glycoprotein	65,79	phosphatidylserine	P-glycoprotein	null	5243	Chemical	Gene	Transport|nmod|START_ENTITY Transport|nmod|END_ENTITY	Transport of phosphatidylserine via MDR1 -LRB- multidrug_resistance_1 -RRB- P-glycoprotein in a human gastric_carcinoma cell line .
11053135	0	phosphatidylserine	60,78	PMP1	0,4	phosphatidylserine	PMP1	null	850389(Tax:4932)	Chemical	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	PMP1 18-38 , a yeast plasma membrane protein fragment , binds phosphatidylserine from bilayer mixtures with phosphatidylcholine : a -LRB- 2 -RRB- H-NMR study .
26961880	0	phosphatidylserine	18,36	Proteinase_3	0,12	phosphatidylserine	Proteinase 3	null	5657	Chemical	Gene	protein|amod|START_ENTITY protein|nsubj|END_ENTITY	Proteinase_3 is a phosphatidylserine binding protein which affects the production and function of microvesicles .
21037090	0	phosphatidylserine	22,40	TIM-4	0,5	phosphatidylserine	TIM-4	null	276891(Tax:10090)	Chemical	Gene	receptor|nmod|START_ENTITY END_ENTITY|appos|receptor	TIM-4 , a receptor for phosphatidylserine , controls adaptive immunity by regulating the removal of antigen-specific T cells .
17960135	0	phosphatidylserine	28,46	Tim4	18,22	phosphatidylserine	Tim4	null	276891(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY Identification|nmod|receptor Identification|nmod|END_ENTITY	Identification of Tim4 as a phosphatidylserine receptor .
2110840	0	phosphatidylserine	134,152	factor_VIII	111,122	phosphatidylserine	factor VIII	null	2157	Chemical	Gene	binding|xcomp|START_ENTITY binding|nsubj|END_ENTITY	Synthetic factor_VIII peptides with amino_acid sequences contained within the C2 domain of factor_VIII inhibit factor_VIII binding to phosphatidylserine .
7801316	0	phosphatidylserine	115,133	melittin	13,21	phosphatidylserine	melittin	null	406130(Tax:7460)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction by melittin of protein phosphorylation in bovine mammary gland and suppression of the phosphorylation by phosphatidylserine .
11104779	0	phosphatidylserine	20,38	phosphatidylserine_decarboxylase_2	65,99	phosphatidylserine	phosphatidylserine decarboxylase 2	null	853080(Tax:4932)	Chemical	Gene	transport|amod|START_ENTITY Characterization|nmod|transport Characterization|nmod|END_ENTITY	Characterization of phosphatidylserine transport to the locus of phosphatidylserine_decarboxylase_2 in permeabilized yeast .
12114511	0	phosphatidylserine	62,80	protein_kinase_C_beta_II	14,38	phosphatidylserine	protein kinase C beta II	null	18751(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	Activation of protein_kinase_C_beta_II by the stereo-specific phosphatidylserine receptor is required for phagocytosis of apoptotic thymocytes by resident murine tissue macrophages .
2481187	0	phosphinic_acid	14,29	angiotensin_I_converting_enzyme	43,74	phosphinic acid	angiotensin I converting enzyme	MESH:D010721	24310(Tax:10116)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|nmod|END_ENTITY	Fosinopril , a phosphinic_acid inhibitor of angiotensin_I_converting_enzyme : in vitro and preclinical in vivo pharmacology .
22206295	0	phosphino-substituted_isocyanate	13,45	CO2	61,64	phosphino-substituted isocyanate	CO2	null	717	Chemical	Gene	START_ENTITY|nmod|reaction reaction|nmod|END_ENTITY	Formation of phosphino-substituted_isocyanate by reaction of CO2 with group 2 complexes based on the -LRB- Me3Si -RRB- -LRB- i-Pr2P -RRB- NH ligand .
1322913	0	phospho	53,60	C-6	49,52	phospho	C-6	null	24237(Tax:10116)	Chemical	Gene	group|compound|START_ENTITY group|compound|END_ENTITY	Lysine 356 is a critical residue for binding the C-6 phospho group of fructose_2 ,6 - bisphosphate to the fructose-2 ,6 - bisphosphatase domain of rat liver 6-phosphofructo-2-kinase / fructose-2 ,6 - bisphosphatase .
25352128	1	phospho-tyrosine	186,202	Syk	243,246	phospho-tyrosine	PF4	CHEBI:74956	56744(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	We have used a novel knock-in mouse to investigate the effect of disruption of phospho-tyrosine binding of the N-terminal SH2 domain of Syk on platelet activation by GPVI , CLEC-2 and integrin aIIbb3 .
23650499	0	phospho-valproic_acid	45,66	STAT3	24,29	phospho-valproic acid	STAT3	null	20848(Tax:10090)	Chemical	Gene	Targeting|nmod|START_ENTITY Targeting|dobj|END_ENTITY	Targeting mitochondrial STAT3 with the novel phospho-valproic_acid -LRB- MDC-1112 -RRB- inhibits pancreatic_cancer growth in mice .
8719442	0	phosphocalcium	29,43	growth_hormone	11,25	phosphocalcium	growth hormone	null	2688	Chemical	Gene	homeostasis|compound|START_ENTITY Effects|nmod|homeostasis Effects|nmod|END_ENTITY	Effects of growth_hormone on phosphocalcium homeostasis and bone metabolism .
10368284	0	phosphocholine	77,91	C-reactive_protein	37,55	phosphocholine	C-reactive protein	MESH:D010767	1401	Chemical	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	The physiological structure of human C-reactive_protein and its complex with phosphocholine .
19218138	0	phosphocreatine	12,27	brain_natriuretic_peptide	38,63	phosphocreatine	brain natriuretic peptide	CHEBI:17287	4879	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	-LSB- Effects of phosphocreatine on plasma brain_natriuretic_peptide level in elderly patients with chronic congestive_heart_failure -RSB- .
7650737	0	phosphodiester	79,93	DNase_I	111,118	phosphodiester	DNase I	null	282217(Tax:9913)	Chemical	Gene	cleavage|compound|START_ENTITY cleavage|nmod|END_ENTITY	The roles of arginine 41 and tyrosine 76 in the coupling of DNA recognition to phosphodiester bond cleavage by DNase_I : a study using site-directed mutagenesis .
8095029	0	phosphoenolpyruvate	33,52	Epidermal_growth_factor	0,23	phosphoenolpyruvate	Epidermal growth factor	MESH:D010728	25313(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Epidermal_growth_factor inhibits phosphoenolpyruvate carboxykinase gene expression in rat hepatocytes in primary culture .
14585510	0	phosphoenolpyruvate	34,53	HNF-1	100,105	phosphoenolpyruvate	HNF-1	MESH:D010728	24817(Tax:10116)	Chemical	Gene	gene|amod|START_ENTITY regulation|nmod|gene requires|nsubj|regulation requires|dobj|site site|compound|END_ENTITY	The transcriptional regulation of phosphoenolpyruvate carboxykinase gene in the kidney requires the HNF-1 binding site of the gene .
9276474	0	phosphoenolpyruvate	42,61	HNF-1	15,20	phosphoenolpyruvate	HNF-1	MESH:D010728	6927	Chemical	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Involvement of HNF-1 in the regulation of phosphoenolpyruvate carboxykinase gene expression in the kidney .
3907706	0	phosphoenolpyruvate	87,106	HPr	65,68	phosphoenolpyruvate	HPr	MESH:D010728	3250	Chemical	Gene	protein|nmod|START_ENTITY protein|appos|END_ENTITY	Characterization of phosphorylated histidine-containing protein -LRB- HPr -RRB- of the bacterial phosphoenolpyruvate : sugar phosphotransferase system .
1452037	0	phosphoglycerate	87,103	glyceraldehyde-3-phosphate_dehydrogenase	45,85	phosphoglycerate	glyceraldehyde-3-phosphate dehydrogenase	CHEBI:61304	9117235	Chemical	Gene	kinase|amod|START_ENTITY kinase|amod|END_ENTITY	Cloning and sequencing of the genes encoding glyceraldehyde-3-phosphate_dehydrogenase , phosphoglycerate kinase and triosephosphate_isomerase -LRB- gap operon -RRB- from mesophilic Bacillus_megaterium : comparison with corresponding sequences from thermophilic Bacillus_stearothermophilus .
6084457	0	phosphoglycolate	92,108	PGP	122,125	phosphoglycolate	PGP	MESH:C013193	283871	Chemical	Gene	phosphatase|amod|START_ENTITY phosphatase|appos|END_ENTITY	Genetic markers in a Malaysian population : variants of uridine_monophosphate_kinase -LRB- UMPK -RRB- , phosphoglycolate phosphatase -LRB- PGP -RRB- and pancreatic amylase -LRB- AMY2 -RRB- .
6614593	0	phosphohexose	37,50	PHI	62,65	phosphohexose	PHI	null	397602(Tax:9823)	Chemical	Gene	isomerase|amod|START_ENTITY isomerase|appos|END_ENTITY	Genetic linkage between the loci for phosphohexose isomerase -LRB- PHI -RRB- and a serum protein -LRB- Xk -RRB- in horses .
3935162	0	phosphohistidine	66,82	ATP-citrate_lyase	134,151	phosphohistidine	ATP-citrate lyase	null	24159(Tax:10116)	Chemical	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	Phosphorus-31 nuclear magnetic resonance study of the active site phosphohistidine and regulatory phosphoserine residues of rat liver ATP-citrate_lyase .
21679093	0	phosphohistidine	23,39	phosphatase_1	40,53	phosphohistidine	phosphatase 1	null	75454(Tax:10090)	Chemical	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	A screening method for phosphohistidine phosphatase_1 activity .
8034624	0	phosphoinositide	14,30	Cdc42Hs	52,59	phosphoinositide	Cdc42Hs	CHEBI:18179	998	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85 .
17601877	0	phosphoinositide	14,30	Sec14p	75,81	phosphoinositide	Sec14p	CHEBI:18179	855103(Tax:4932)	Chemical	Gene	levels|amod|START_ENTITY levels|nmod|END_ENTITY	Regulation of phosphoinositide levels by the phospholipid transfer protein Sec14p controls Cdc42p/p21-activated kinase-mediated cell cycle progression at cytokinesis .
1966371	0	phosphoinositide	28,44	bradykinin	14,24	phosphoinositide	bradykinin	CHEBI:18179	280833(Tax:9913)	Chemical	Gene	metabolism|amod|START_ENTITY Regulation|nmod|metabolism Regulation|nmod|END_ENTITY	Regulation by bradykinin of phosphoinositide metabolism in the endothelial cells of the pulmonary artery .
21106690	0	phosphoinositide	55,71	epithelial_sodium_channel	18,43	phosphoinositide	epithelial sodium channel	CHEBI:18179	20276(Tax:10090)	Chemical	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	Insulin activates epithelial_sodium_channel -LRB- ENaC -RRB- via phosphoinositide 3-kinase in mammalian taste receptor cells .
8895571	0	phosphoinositide	89,105	mammalian_target_of_rapamycin	52,81	phosphoinositide	mammalian target of rapamycin	CHEBI:18179	2475	Chemical	Gene	inhibitors|amod|START_ENTITY END_ENTITY|nmod|inhibitors	Direct inhibition of the signaling functions of the mammalian_target_of_rapamycin by the phosphoinositide 3-kinase inhibitors , wortmannin and LY294002 .
7982262	0	phosphoinositide	14,30	parathyroid_hormone	45,64	phosphoinositide	parathyroid hormone	CHEBI:18179	5741	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|nmod|END_ENTITY	Activation of phosphoinositide metabolism by parathyroid_hormone in growth plate chondrocytes .
7986078	0	phosphoinositide	97,113	parathyroid_hormone	64,83	phosphoinositide	parathyroid hormone	CHEBI:18179	5741	Chemical	Gene	stimulate|dobj|START_ENTITY required|xcomp|stimulate required|nmod|END_ENTITY	Cyclic-AMP-dependent protein kinase activity is not required by parathyroid_hormone to stimulate phosphoinositide signaling in chondrocytes but is required to transduce the hormone 's proliferative effect .
10464307	0	phosphoinositides	31,48	AMP_deaminase	14,27	phosphoinositides	AMP deaminase	MESH:D010716	270	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of AMP_deaminase by phosphoinositides .
10801341	0	phosphoinositides	62,79	ARNO	54,58	phosphoinositides	ARNO	MESH:D010716	9266	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of the PH and polybasic C-terminal domains of ARNO to phosphoinositides and to acidic lipids .
12589044	0	phosphoinositides	102,119	Arf6	69,73	phosphoinositides	Arf6	MESH:D010716	382	Chemical	Gene	inactivation|nmod|START_ENTITY inactivation|amod|END_ENTITY	Convergence of non-clathrin - and clathrin-derived endosomes involves Arf6 inactivation and changes in phosphoinositides .
20374427	0	phosphoinositides	46,63	P2X1/5	26,32	phosphoinositides	P2X1/5	MESH:D010716	5023;5026	Chemical	Gene	receptors|nmod|START_ENTITY receptors|compound|END_ENTITY	Modulation of heteromeric P2X1/5 receptors by phosphoinositides in astrocytes depends on the P2X1 subunit .
19671169	0	phosphoinositides	60,77	P2X3	31,35	phosphoinositides	P2X3	MESH:D010716	5024	Chemical	Gene	receptors|nmod|START_ENTITY receptors|nsubj|regulation regulation|nmod|END_ENTITY	Subtype-specific regulation of P2X3 and P2X2/3 receptors by phosphoinositides in peripheral nociceptors .
17596456	0	phosphoinositides	28,45	TRPV1	19,24	phosphoinositides	TRPV1	MESH:D010716	7442	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Dual regulation of TRPV1 by phosphoinositides .
17339315	0	phosphoinositides	29,46	Tiam1	83,88	phosphoinositides	Tiam1	MESH:D010716	7074	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Non-canonical interaction of phosphoinositides with pleckstrin homology domains of Tiam1 and ArhGAP9 .
3000732	0	phosphoinositides	44,61	thyrotropin-releasing_hormone	11,40	phosphoinositides	thyrotropin-releasing hormone	MESH:D010716	25569(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of thyrotropin-releasing_hormone on phosphoinositides and cytoplasmic free calcium in thyrotropic pituitary cells .
2990238	0	phosphoinositides	26,43	vasopressin	11,22	phosphoinositides	vasopressin	MESH:D010716	551	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of vasopressin on phosphoinositides and prostaglandin production in cultured mesangial cells .
17673673	0	phosphoinositol	106,121	Nrf2	159,163	phosphoinositol	Nrf2	null	4780	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Biomechanical forces in atherosclerosis-resistant vascular regions regulate endothelial redox balance via phosphoinositol 3-kinase/Akt-dependent activation of Nrf2 .
9823298	0	phosphoinositol	4,19	PTEN	44,48	phosphoinositol	PTEN	null	5728	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cells .
19082482	0	phosphoinositol	6,21	SHIP2	0,5	phosphoinositol	SHIP2	null	3636	Chemical	Gene	phosphatase|amod|START_ENTITY phosphatase|nummod|END_ENTITY	SHIP2 phosphoinositol phosphatase positively regulates EGFR-Akt pathway , CXCR4 expression , and cell migration in MDA-MB-231 breast_cancer cells .
3211365	0	phosphoinositol	43,58	Transforming_growth_factor_beta	0,31	phosphoinositol	Transforming growth factor beta	null	7040	Chemical	Gene	metabolism|amod|START_ENTITY stimulates|dobj|metabolism stimulates|nsubj|END_ENTITY	Transforming_growth_factor_beta stimulates phosphoinositol metabolism and translocation of protein kinase C in cultured astrocytes .
23574264	0	phosphoinositol-3	67,84	PIK3CA	99,105	phosphoinositol-3	PIK3CA	null	5290	Chemical	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	The predictive role of phosphatase and tensin homolog -LRB- PTEN -RRB- loss , phosphoinositol-3 -LRB- PI3 -RRB- kinase -LRB- PIK3CA -RRB- mutation , and PI3K pathway activation in sensitivity to trastuzumab in HER2-positive_breast_cancer : a meta-analysis .
11278560	0	phosphoinositol_phosphate	40,65	DBL	24,27	phosphoinositol phosphate	DBL	null	4168	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Modulation of oncogenic DBL activity by phosphoinositol_phosphate binding to pleckstrin homology domain .
25356636	0	phosphoinositol_phosphates	55,81	SSeCKS	29,35	phosphoinositol phosphates	SSeCKS	null	9590	Chemical	Gene	Suppression|nmod|START_ENTITY Suppression|nmod|END_ENTITY	Suppression of chemotaxis by SSeCKS via scaffolding of phosphoinositol_phosphates and the recruitment of the Cdc42 GEF , Frabin , to the leading edge .
3137962	0	phospholipid	6,18	myosin	50,56	phospholipid	myosin	CHEBI:16247	79784	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|compound|END_ENTITY	Ca2 + , phospholipid and Ca2 + , calmodulin-dependent myosin light chain phosphorylation of smooth muscle and nonmuscle cells .
18801364	0	phosphomannose	56,70	PslB	93,97	phosphomannose	PslB	null	880925(Tax:208964)	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Identification of amino_acid residues important for the phosphomannose isomerase activity of PslB in Pseudomonas_aeruginosa_PAO1 .
1796353	0	phosphomonoesters	11,28	CA1	32,35	phosphomonoesters	CA1	null	310218(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|neurons neurons|compound|END_ENTITY	Actions of phosphomonoesters on CA1 hippocampal neurons as revealed by a combined electrophysiological and nuclear magnetic resonance study .
17257836	0	phosphonate	39,50	autotaxin	66,75	phosphonate	autotaxin	CHEBI:26066	5168	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Synthesis and biological evaluation of phosphonate derivatives as autotaxin -LRB- ATX -RRB- inhibitors .
10732971	0	phosphonate_esters	55,73	factor_Xa	31,40	phosphonate esters	factor Xa	null	2159	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Reversible modulation of human factor_Xa activity with phosphonate_esters : media effects .
7532720	0	phosphonopeptides	70,87	p56lck	44,50	phosphonopeptides	p56lck	null	3932	Chemical	Gene	complexed|nmod|START_ENTITY END_ENTITY|acl|complexed	The crystal structures of the SH2 domain of p56lck complexed with two phosphonopeptides suggest a gated peptide binding site .
17341634	0	phosphopeptides	34,49	Grb2-associated_binder_1	117,141	phosphopeptides	Grb2-associated binder 1	MESH:D010748	2549	Chemical	Gene	activity|nmod|START_ENTITY activity|nmod|END_ENTITY	Design and functional activity of phosphopeptides with potential immunomodulating capacity , based on the sequence of Grb2-associated_binder_1 .
8619258	0	phosphoramidates	64,80	acetylcholinesterase	30,50	phosphoramidates	acetylcholinesterase	null	43	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubj|reactivation reactivation|nmod|END_ENTITY	Oxime-induced reactivation of acetylcholinesterase inhibited by phosphoramidates .
9426079	0	phosphoramidon	46,60	Neutral_endopeptidase	0,21	phosphoramidon	Neutral endopeptidase	MESH:C008890	4311	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Neutral_endopeptidase inhibition with inhaled phosphoramidon : no effect on bronchial responsiveness to adenosine_5 ' - monophosphate -LRB- AMP -RRB- in asthma .
7599928	0	phosphoramidon	24,38	angiotensin_II	67,81	phosphoramidon	angiotensin II	MESH:C008890	24179(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Differential effects of phosphoramidon on contractile responses to angiotensin_II in rat blood vessels .
7550091	0	phosphoramidon	11,25	endothelin-1	29,41	phosphoramidon	endothelin-1	MESH:C008890	1906	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|production production|amod|END_ENTITY	Effects of phosphoramidon on endothelin-1 and big endothelin-1 production in human aortic endothelial cells .
7550091	0	phosphoramidon	11,25	endothelin-1	50,62	phosphoramidon	endothelin-1	MESH:C008890	1906	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|production production|amod|END_ENTITY	Effects of phosphoramidon on endothelin-1 and big endothelin-1 production in human aortic endothelial cells .
7924171	0	phosphoramidon	11,25	endothelin-1	62,74	phosphoramidon	endothelin-1	MESH:C008890	1906	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|nmod|endothelin-1 endothelin-1|amod|END_ENTITY	Effects of phosphoramidon and pepstatin_A on the secretion of endothelin-1 and big endothelin-1 by human umbilical vein endothelial cells : measurement by two-site enzyme-linked immunosorbent assays .
7924171	0	phosphoramidon	11,25	endothelin-1	83,95	phosphoramidon	endothelin-1	MESH:C008890	1906	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|nmod|END_ENTITY	Effects of phosphoramidon and pepstatin_A on the secretion of endothelin-1 and big endothelin-1 by human umbilical vein endothelial cells : measurement by two-site enzyme-linked immunosorbent assays .
1468574	0	phosphoramidon	10,24	endothelin-2	61,73	phosphoramidon	endothelin-2	MESH:C008890	1907	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|cells cells|amod|END_ENTITY	Effect of phosphoramidon on big endothelin-2 conversion into endothelin-2 in human renal_adenocarcinoma -LRB- ACHN -RRB- cells .
6363990	0	phosphoramidon	10,24	enkephalinase	39,52	phosphoramidon	enkephalinase	MESH:C008890	24590(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|inhibitor inhibitor|compound|END_ENTITY	Effect of phosphoramidon - a selective enkephalinase inhibitor - on nociception and behaviour .
7597662	0	phosphoramidon	54,68	neutral_endopeptidase	21,42	phosphoramidon	neutral endopeptidase	MESH:C008890	4311	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Effect of an inhaled neutral_endopeptidase inhibitor , phosphoramidon , on baseline airway calibre and bronchial responsiveness to bradykinin in asthma .
15612645	0	phosphoramidothioate	14,34	Ace	36,39	phosphoramidothioate	Ace	null	41625(Tax:7227)	Chemical	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	QSAR study on phosphoramidothioate -LRB- Ace -RRB- toxicities in housefly .
12494248	0	phosphoribosyl	133,147	dihydropyrimidine_dehydrogenase	89,120	phosphoribosyl	dihydropyrimidine dehydrogenase	null	1806	Chemical	Gene	activities|amod|START_ENTITY END_ENTITY|dobj|activities	Predicting 5-FU sensitivity using human colorectal_cancer specimens : comparison of tumor dihydropyrimidine_dehydrogenase and orotate phosphoribosyl transferase activities with in vitro chemosensitivity to 5-FU .
2168892	0	phosphoribosylpyrophosphate	33,60	testis-specific	8,23	phosphoribosylpyrophosphate	testis-specific	MESH:D010754	51298	Chemical	Gene	mRNA|nmod|START_ENTITY mRNA|amod|END_ENTITY	A human testis-specific mRNA for phosphoribosylpyrophosphate synthetase that initiates from a non-AUG codon .
11819791	0	phosphorthioate	48,63	TIMP-1	86,92	phosphorthioate	TIMP-1	null	116510(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Inhibiting effect of antisense oligonucleotides phosphorthioate on gene expression of TIMP-1 in rat liver fibrosis .
3295473	0	phosphorus	88,98	25-hydroxyvitamin_D3-1_alpha-hydroxylase	44,84	phosphorus	25-hydroxyvitamin D3-1 alpha-hydroxylase	MESH:D010758	114700(Tax:10116)	Chemical	Gene	deprivation|compound|START_ENTITY END_ENTITY|nmod|deprivation	Role of insulin in the stimulation of renal 25-hydroxyvitamin_D3-1_alpha-hydroxylase by phosphorus deprivation in rats .
7892964	0	phosphorus	38,48	ACTH	11,15	phosphorus	ACTH	MESH:D010758	5443	Chemical	Gene	treatment|nmod|START_ENTITY treatment|amod|END_ENTITY	Effects of ACTH treatment on cerebral phosphorus metabolites in infants with the West_syndrome .
12145936	0	phosphorus	68,78	COD	15,18	phosphorus	COD	MESH:D010758	6628	Chemical	Gene	removal|compound|START_ENTITY END_ENTITY|nmod|removal	-LSB- Effect of the COD and total phosphorus concentration on biological phosphorus removal supplied with acetate as a sole carbon source -RSB- .
14971455	0	phosphorus	72,82	MBR	94,97	phosphorus	MBR	MESH:D010758	706	Chemical	Gene	removal|compound|START_ENTITY removal|nmod|END_ENTITY	Determination of operational parameters of anaerobic phase for enhanced phosphorus removal in MBR .
12875848	0	phosphorus	14,24	N-acetyl-L-glutamate_kinase	44,71	phosphorus	N-acetyl-L-glutamate kinase	MESH:D010758	55577	Chemical	Gene	START_ENTITY|nmod|reaction reaction|nmod|END_ENTITY	The course of phosphorus in the reaction of N-acetyl-L-glutamate_kinase , determined from the structures of crystalline complexes , including a complex with an AlF -LRB- 4 -RRB- -LRB- - -RRB- transition state mimic .
14745193	0	phosphorus	29,39	PTH	65,68	phosphorus	PTH	MESH:D010758	24694(Tax:10116)	Chemical	Gene	START_ENTITY|advmod|regardless regardless|nmod|action action|compound|END_ENTITY	High phosphorus diet changes phosphorus metabolism regardless of PTH action in rats .
14745193	0	phosphorus	5,15	PTH	65,68	phosphorus	PTH	MESH:D010758	24694(Tax:10116)	Chemical	Gene	changes|compound|START_ENTITY phosphorus|nsubj|changes phosphorus|advmod|regardless regardless|nmod|action action|compound|END_ENTITY	High phosphorus diet changes phosphorus metabolism regardless of PTH action in rats .
15775644	0	phosphorus	61,71	PTH	44,47	phosphorus	PTH	MESH:D010758	5741	Chemical	Gene	-RSB-|compound|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- The regulation of vitamin_D metabolism and PTH secretion by phosphorus -RSB- .
16395276	0	phosphorus	29,39	PTH	77,80	phosphorus	PTH	MESH:D010758	24694(Tax:10116)	Chemical	Gene	manipulating|dobj|START_ENTITY manipulating|advcl|circulating circulating|dobj|END_ENTITY	Effect of manipulating serum phosphorus with phosphate binder on circulating PTH and FGF23 in renal_failure rats .
17717030	0	phosphorus	106,116	PTH	60,63	phosphorus	PTH	MESH:D010758	5741	Chemical	Gene	control|nmod|START_ENTITY level|nmod|control level|compound|END_ENTITY	Cinacalcet -LRB- KRN1493 -RRB- effectively decreases the serum intact PTH level with favorable control of the serum phosphorus and calcium levels in Japanese dialysis patients .
2769173	0	phosphorus	23,33	PTH	117,120	phosphorus	PTH	MESH:D010758	5741	Chemical	Gene	rates|amod|START_ENTITY effects|nmod|rates effects|nmod|response response|nmod|END_ENTITY	The effects of dietary phosphorus and parathyroid_hormone -LRB- PTH -RRB- infusion rates on the avian phosphaturic response to PTH .
2996369	0	phosphorus	27,37	PTH	76,79	phosphorus	PTH	MESH:D010758	24694(Tax:10116)	Chemical	Gene	handling|compound|START_ENTITY insulin|nmod|handling Effect|nmod|insulin Effect|dep|interaction interaction|nmod|END_ENTITY	Effect of insulin on renal phosphorus handling in the rat : interaction with PTH and nicotinamide .
8647946	1	phosphorus	63,73	PTH	94,97	phosphorus	PTH	MESH:D010758	24694(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|compound|END_ENTITY	High phosphorus directly stimulates PTH secretion in vitro .
8797118	0	phosphorus	17,27	PTH	31,34	phosphorus	PTH	MESH:D010758	24694(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Direct effect of phosphorus on PTH secretion from whole rat parathyroid glands in vitro .
11499657	0	phosphorus	35,45	Parathyroid_hormone	0,19	phosphorus	Parathyroid hormone	MESH:D010758	5741	Chemical	Gene	load|compound|START_ENTITY changes|nmod|load changes|nsubj|END_ENTITY	Parathyroid_hormone changes during phosphorus load in patients with chronic_renal_insufficiency with low serum parathyroid_hormone or adynamic_bone_disease .
22677630	0	phosphorus	18,28	PepT1	74,79	phosphorus	PepT1	MESH:D010758	117261(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Dietary inorganic phosphorus regulates the intestinal peptide transporter PepT1 .
16787855	0	phosphorus	77,87	Phytase	0,7	phosphorus	Phytase	MESH:D010758	100778145	Chemical	Gene	effects|nmod|START_ENTITY effects|amod|END_ENTITY	Phytase effects on the efficiency of utilisation and blood concentrations of phosphorus and calcium in Pekin_ducks .
15692183	0	phosphorus	16,26	SEN1	53,57	phosphorus	SEN1	MESH:D010758	823701(Tax:3702)	Chemical	Gene	effects|nmod|START_ENTITY -LSB-|dobj|effects -LSB-|nmod|expression expression|compound|END_ENTITY	-LSB- The effects of phosphorus , glucose and cytokinin on SEN1 gene expression in Arabidopsis -RSB- .
23146451	0	phosphorus	65,75	fibroblast_growth_factor_23	8,35	phosphorus	fibroblast growth factor 23	MESH:D010758	8074	Chemical	Gene	metabolism|nmod|START_ENTITY Role|nmod|metabolism Role|nmod|END_ENTITY	Role of fibroblast_growth_factor_23 -LRB- FGF23 -RRB- in the metabolism of phosphorus and calcium immediately after kidney transplantation .
1011167	0	phosphorus	64,74	growth_hormone	41,55	phosphorus	growth hormone	MESH:D010758	81668(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	-LSB- Need of thyroxine in chronic effects of growth_hormone -LRB- GH -RRB- on phosphorus and calcium metabolism of female adult rat -LRB- author 's transl -RRB- -RSB- .
7485139	0	phosphorus	79,89	insulin-like_growth_factor_1	29,57	phosphorus	insulin-like growth factor 1	MESH:D010758	3479	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of recombinant human insulin-like_growth_factor_1 on renal handling of phosphorus , calcium , and sodium in normal humans .
10495131	0	phosphorus	103,113	parathyroid_hormone	35,54	phosphorus	parathyroid hormone	MESH:D010758	24694(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY Dynamics|dep|effect Dynamics|acl|END_ENTITY	Dynamics of skeletal resistance to parathyroid_hormone in the rat : effect of renal_failure and dietary phosphorus .
10596962	0	phosphorus	47,57	parathyroid_hormone	9,28	phosphorus	parathyroid hormone	MESH:D010758	24694(Tax:10116)	Chemical	Gene	excretion|compound|START_ENTITY END_ENTITY|nmod|excretion	Impaired parathyroid_hormone action on urinary phosphorus excretion in isolated perfused kidney of streptozotocin-induced diabetic rats .
11499657	0	phosphorus	35,45	parathyroid_hormone	111,130	phosphorus	parathyroid hormone	MESH:D010758	5741	Chemical	Gene	load|compound|START_ENTITY changes|nmod|load changes|nmod|serum serum|amod|END_ENTITY	Parathyroid_hormone changes during phosphorus load in patients with chronic_renal_insufficiency with low serum parathyroid_hormone or adynamic_bone_disease .
16495674	0	phosphorus	40,50	parathyroid_hormone	59,78	phosphorus	parathyroid hormone	MESH:D010758	24694(Tax:10116)	Chemical	Gene	diet|compound|START_ENTITY diet|nmod|actions actions|amod|END_ENTITY	Effects of lowering food intake by high phosphorus diet on parathyroid_hormone actions and kidney mineral concentration in rats .
1762306	0	phosphorus	67,77	parathyroid_hormone	21,40	phosphorus	parathyroid hormone	MESH:D010758	24694(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY response|dep|role response|acl|END_ENTITY	Calcemic response to parathyroid_hormone in renal_failure : role of phosphorus and its effect on calcitriol .
186491	0	phosphorus	47,57	parathyroid_hormone	20,39	phosphorus	parathyroid hormone	MESH:D010758	24694(Tax:10116)	Chemical	Gene	deprivation|compound|START_ENTITY END_ENTITY|nmod|deprivation	Renal resistance to parathyroid_hormone during phosphorus deprivation .
19781123	0	phosphorus	12,22	parathyroid_hormone	61,80	phosphorus	parathyroid hormone	MESH:D010758	5741	Chemical	Gene	ratio|compound|START_ENTITY affects|nsubj|ratio affects|dobj|concentration concentration|compound|END_ENTITY	Low calcium : phosphorus ratio in habitual diets affects serum parathyroid_hormone concentration and calcium metabolism in healthy women with adequate calcium intake .
22863242	0	phosphorus	9,19	parathyroid_hormone	39,58	phosphorus	parathyroid hormone	MESH:D010758	5741	Chemical	Gene	control|nsubj|START_ENTITY control|acl|related related|xcomp|END_ENTITY	Is serum phosphorus control related to parathyroid_hormone control in dialysis patients with secondary_hyperparathyroidism ?
23208191	0	phosphorus	65,75	parathyroid_hormone	35,54	phosphorus	parathyroid hormone	MESH:D010758	5741	Chemical	Gene	START_ENTITY|nsubj|Relationship Relationship|nmod|reductions reductions|nmod|END_ENTITY	Relationship between reductions in parathyroid_hormone and serum phosphorus during the management of secondary_hyperparathyroidism with calcimimetics in hemodialysis patients .
23717787	0	phosphorus	6,16	parathyroid_hormone	126,145	phosphorus	parathyroid hormone	MESH:D010758	5741	Chemical	Gene	reduction|compound|START_ENTITY treated|nsubj|reduction treated|nmod|reduction reduction|amod|END_ENTITY	Serum phosphorus reduction in dialysis patients treated with cinacalcet for secondary_hyperparathyroidism results mainly from parathyroid_hormone reduction .
24975224	0	phosphorus	5,15	parathyroid_hormone	139,158	phosphorus	parathyroid hormone	MESH:D010758	24694(Tax:10116)	Chemical	Gene	supplementation|compound|START_ENTITY increases|nsubj|supplementation increases|xcomp|circulating circulating|advmod|partially partially|nmod|stimulation stimulation|nmod|secretion secretion|amod|END_ENTITY	Oral phosphorus supplementation secondarily increases circulating fibroblast_growth_factor_23 levels at least partially via stimulation of parathyroid_hormone secretion .
7187765	0	phosphorus	109,119	parathyroid_hormone	17,36	phosphorus	parathyroid hormone	MESH:D010758	101120013	Chemical	Gene	influence|nmod|START_ENTITY influence|nmod|END_ENTITY	The influence of parathyroid_hormone and calcitonin on urinary excretion of calcium , magnesium and inorganic phosphorus in chronically catheterized foetal lambs in utero .
7566311	0	phosphorus	183,193	parathyroid_hormone	23,42	phosphorus	parathyroid hormone	MESH:D010758	24694(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY Prevention|dep|role Prevention|nmod|secretion secretion|compound|END_ENTITY	Prevention of enhanced parathyroid_hormone secretion , synthesis and hyperplasia by mild dietary phosphorus restriction in early chronic_renal_failure in rats : possible direct role of phosphorus .
7566311	0	phosphorus	96,106	parathyroid_hormone	23,42	phosphorus	parathyroid hormone	MESH:D010758	24694(Tax:10116)	Chemical	Gene	restriction|compound|START_ENTITY secretion|nmod|restriction secretion|compound|END_ENTITY	Prevention of enhanced parathyroid_hormone secretion , synthesis and hyperplasia by mild dietary phosphorus restriction in early chronic_renal_failure in rats : possible direct role of phosphorus .
8393953	0	phosphorus	73,83	parathyroid_hormone	32,51	phosphorus	parathyroid hormone	MESH:D010758	5741	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|acl|calcitriol calcitriol|nmod|END_ENTITY	The regulation of calcitriol by parathyroid_hormone and absorbed dietary phosphorus in subjects with moderate_chronic_renal_failure .
10472841	0	phosphorus	57,67	phytase	38,45	phosphorus	phytase	MESH:D010758	100778145	Chemical	Gene	hydrolysis|compound|START_ENTITY END_ENTITY|nmod|hydrolysis	A bioassay to determine the effect of phytase on phytate phosphorus hydrolysis and total phosphorus retention of feed ingredients as determined with broilers and laying hens .
8394307	0	phosphorus	56,66	phytase	12,19	phosphorus	phytase	MESH:D010758	100778145	Chemical	Gene	bioavailability|nmod|START_ENTITY improving|dobj|bioavailability END_ENTITY|acl|improving	Efficacy of phytase in improving the bioavailability of phosphorus in soybean meal and corn-soybean meal diets for pigs .
12952980	0	phosphorylate	65,78	protein_kinase_C_alpha	29,51	phosphorylate	protein kinase C alpha	null	5578	Chemical	Gene	signaling|xcomp|START_ENTITY END_ENTITY|acl|signaling	Apolipoprotein_A-I activates protein_kinase_C_alpha signaling to phosphorylate and stabilize ATP binding cassette transporter A1 for the high density lipoprotein assembly .
21475921	0	phosphorylated_ascorbate	23,47	p53	151,154	phosphorylated ascorbate	p53	null	7157	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|gene gene|compound|END_ENTITY	Suppressive effects of phosphorylated_ascorbate on ultraviolet B radiation-induced DNA damage and differential expression of the wild-type and mutated p53 tumor-suppressor gene in keratinocytes .
8286343	0	phosphorylated_epoxides	58,81	glyceraldehyde-3-phosphate_dehydrogenase	14,54	phosphorylated epoxides	glyceraldehyde-3-phosphate dehydrogenase	null	100009074(Tax:9986)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of glyceraldehyde-3-phosphate_dehydrogenase by phosphorylated_epoxides and alpha-enones .
23601990	0	phosphorylated_flavonoids	39,64	cholesterol_esterase	103,123	phosphorylated flavonoids	cholesterol esterase	null	1056	Chemical	Gene	evaluation|nmod|START_ENTITY evaluation|nmod|END_ENTITY	Synthesis and biological evaluation of phosphorylated_flavonoids as potent and selective inhibitors of cholesterol_esterase .
11684681	0	phosphorylcholine	58,75	C-reactive_protein	35,53	phosphorylcholine	C-reactive protein	MESH:D010767	1401	Chemical	Gene	compounds|amod|START_ENTITY END_ENTITY|nmod|compounds	Mapping the binding areas of human C-reactive_protein for phosphorylcholine and polycationic compounds .
1071718	0	phosphorylethanolamine	37,59	Renin	0,5	phosphorylethanolamine	Renin	MESH:C005448	24715(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|compound|END_ENTITY	Renin inhibitory effect of synthetic phosphorylethanolamine -LRB- PE-104 -RRB- in the rat .
15478465	0	phosphorylethanolamine	80,102	Serum_amyloid_P_component	0,25	phosphorylethanolamine	Serum amyloid P component	MESH:C005448	325	Chemical	Gene	affinity|nmod|START_ENTITY END_ENTITY|nmod|affinity	Serum_amyloid_P_component in mink , a non-glycosylated protein with affinity for phosphorylethanolamine and phosphorylcholine .
6743332	0	phosphorylethanolamine	84,106	ornithine_decarboxylase	14,37	phosphorylethanolamine	ornithine decarboxylase	MESH:C005448	4953	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activities activities|amod|END_ENTITY	Inhibition of ornithine_decarboxylase and glutamic_acid decarboxylase activities by phosphorylethanolamine and phosphorylcholine .
314815	0	phosphorylserine	104,120	phosvitin	133,142	phosphorylserine	phosvitin	null	539235(Tax:9913)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Iron -LRB- III -RRB- -- phosphoprotein chelates : stoichiometric equilibrium constant for interation of iron -LRB- III -RRB- and phosphorylserine residues of phosvitin and casein .
22908299	0	phosphoserine	20,33	H2A.X	73,78	phosphoserine	H2A.X	CHEBI:15811	3014	Chemical	Gene	recognition|nmod|START_ENTITY recognition|nmod|END_ENTITY	Dual recognition of phosphoserine and phosphotyrosine in histone variant H2A.X by DNA damage response protein MCPH1 .
6297854	0	phosphoserine	24,37	PSP	56,59	phosphoserine	PSP	CHEBI:15811	5723	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Assignment of the human phosphoserine phosphatase gene -LRB- PSP -RRB- to the pter leads to q22 region of chromosome 7 .
6297855	0	phosphoserine	10,23	PSP	42,45	phosphoserine	PSP	CHEBI:15811	5723	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The human phosphoserine phosphatase gene -LRB- PSP -RRB- is mapped to chromosome 7 by somatic cell genetic analysis .
3038909	0	phosphoserine	16,29	tRNA	30,34	phosphoserine	tRNA	CHEBI:15811	4563	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Opal suppressor phosphoserine tRNA gene and pseudogene are located on human chromosomes 19 and 22 , respectively .
11246465	0	phosphotyrosine	13,28	ACP1	50,54	phosphotyrosine	ACP1	CHEBI:74956	52	Chemical	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Human 18 kDa phosphotyrosine protein phosphatase -LRB- ACP1 -RRB- polymorphism : studies of rare variants provide evidence that substitutions within or near alternatively spliced exons affect splicing result .
1533589	0	phosphotyrosine	61,76	CD45	56,60	phosphotyrosine	CD45	CHEBI:74956	5788	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|compound|END_ENTITY	Regulation of the p59fyn protein tyrosine kinase by the CD45 phosphotyrosine phosphatase .
2548204	0	phosphotyrosine	75,90	CD45	70,74	phosphotyrosine	CD45	CHEBI:74956	19264(Tax:10090)	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|compound|END_ENTITY	Rapid activation of the T-cell tyrosine protein kinase pp56lck by the CD45 phosphotyrosine phosphatase .
7507203	0	phosphotyrosine	33,48	CD45	28,32	phosphotyrosine	CD45	CHEBI:74956	5788	Chemical	Gene	phosphatase|amod|START_ENTITY phosphatase|nummod|END_ENTITY	Tyrosine phosphorylation of CD45 phosphotyrosine phosphatase by p50csk kinase creates a binding site for p56lck tyrosine kinase and activates the phosphatase .
7737297	0	phosphotyrosine	72,87	CD45	67,71	phosphotyrosine	CD45	CHEBI:74956	5788	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|compound|END_ENTITY	Regulation of the p70zap tyrosine protein kinase in T cells by the CD45 phosphotyrosine phosphatase .
10490604	0	phosphotyrosine	42,57	Cbl	18,21	phosphotyrosine	Cbl	CHEBI:74956	867	Chemical	Gene	binding|amod|START_ENTITY regulation|amod|binding blocks|dobj|regulation blocks|nsubj|mutation mutation|compound|END_ENTITY	The oncogenic 70Z Cbl mutation blocks the phosphotyrosine binding domain-dependent negative regulation of ZAP-70 by c-Cbl in Jurkat T cells .
15737992	0	phosphotyrosine	43,58	Cbl	39,42	phosphotyrosine	Cbl	CHEBI:74956	867	Chemical	Gene	START_ENTITY|nsubj|characterization characterization|nmod|END_ENTITY	Structural characterization of a novel Cbl phosphotyrosine recognition motif in the APS family of adapter proteins .
12665569	0	phosphotyrosine	61,76	Dok-R	55,60	phosphotyrosine	Dok-R	CHEBI:74956	13449(Tax:10090)	Chemical	Gene	domain|compound|START_ENTITY domain|amod|END_ENTITY	A unique autophosphorylation site on Tie2/Tek mediates Dok-R phosphotyrosine binding domain binding and function .
8548846	0	phosphotyrosine	10,25	Fc_gamma_RIIIA	40,54	phosphotyrosine	Fc gamma RIIIA	CHEBI:74956	2214	Chemical	Gene	START_ENTITY|xcomp|signaling signaling|nmod|END_ENTITY	Divergent phosphotyrosine signaling via Fc_gamma_RIIIA on human NK cells .
18650440	0	phosphotyrosine	28,43	Fe65L1	66,72	phosphotyrosine	Fe65L1	CHEBI:74956	11787(Tax:10090)	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Structure of the C-terminal phosphotyrosine interaction domain of Fe65L1 complexed with the cytoplasmic tail of amyloid_precursor_protein reveals a novel peptide binding mode .
23415435	0	phosphotyrosine	98,113	GULP	132,136	phosphotyrosine	GULP	CHEBI:74956	51454	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Cholesterol trapping in Niemann-Pick_disease_type_B fibroblasts can be relieved by expressing the phosphotyrosine binding domain of GULP .
20222723	0	phosphotyrosine	47,62	HGF	25,28	phosphotyrosine	HGF	CHEBI:74956	3082	Chemical	Gene	START_ENTITY|nsubj|analysis analysis|nmod|END_ENTITY	Quantitative analysis of HGF and EGF-dependent phosphotyrosine signaling networks .
20226764	5	phosphotyrosine	665,680	IRS-3	699,704	phosphotyrosine	IRS-3	CHEBI:74956	442338	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	We found that Bcl-3 interacts with the pleckstrin homology domain and the phosphotyrosine binding domain of IRS-3 , and that IRS-3 interacts with the ankyrin repeat domain of Bcl-3 .
9278318	0	phosphotyrosine	12,27	Lck	4,7	phosphotyrosine	Lck	CHEBI:74956	3932	Chemical	Gene	site|compound|START_ENTITY site|compound|END_ENTITY	The Lck SH2 phosphotyrosine binding site is critical for efficient TCR-induced processive tyrosine phosphorylation of the zeta-chain and IL-2 production .
19008309	0	phosphotyrosine	58,73	Leptin	0,6	phosphotyrosine	Leptin	CHEBI:74956	3952	Chemical	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Leptin but not ciliary_neurotrophic_factor -LRB- CNTF -RRB- induces phosphotyrosine phosphatase-1B expression in human neuronal cells -LRB- SH-SY5Y -RRB- : putative explanation of CNTF efficacy in leptin-resistant state .
16636066	0	phosphotyrosine	4,19	Nck1	51,55	phosphotyrosine	Nck1	CHEBI:74956	4690	Chemical	Gene	specificity|amod|START_ENTITY specificity|nmod|END_ENTITY	The phosphotyrosine peptide binding specificity of Nck1 and Nck2 Src homology 2 domains .
9418906	0	phosphotyrosine	42,57	Numb	76,80	phosphotyrosine	Numb	CHEBI:74956	8650	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Numb-associated_kinase interacts with the phosphotyrosine binding domain of Numb and antagonizes the function of Numb in vivo .
8662748	0	phosphotyrosine	21,36	SHC	90,93	phosphotyrosine	SHC	CHEBI:74956	6464	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Interaction with the phosphotyrosine binding domain/phosphotyrosine interacting domain of SHC is required for the transforming activity of the FLT4/VEGFR3 receptor tyrosine kinase .
11021818	0	phosphotyrosine	8,23	SHP-1	120,125	phosphotyrosine	SHP-1	CHEBI:74956	8431	Chemical	Gene	expression|amod|START_ENTITY Lack|nmod|expression results|nsubj|Lack results|nmod|methylation methylation|nmod|promoter promoter|compound|END_ENTITY	Lack of phosphotyrosine phosphatase SHP-1 expression in malignant T-cell_lymphoma cells results from methylation of the SHP-1 promoter .
11021818	0	phosphotyrosine	8,23	SHP-1	36,41	phosphotyrosine	SHP-1	CHEBI:74956	8431	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Lack of phosphotyrosine phosphatase SHP-1 expression in malignant T-cell_lymphoma cells results from methylation of the SHP-1 promoter .
14652006	0	phosphotyrosine	20,35	SHP-1	170,175	phosphotyrosine	SHP-1	CHEBI:74956	8431	Chemical	Gene	motifs|amod|START_ENTITY Characterization|nmod|motifs Characterization|acl|required required|nmod|phosphatases phosphatases|amod|END_ENTITY	Characterization of phosphotyrosine binding motifs in the cytoplasmic domain of B_and_T_lymphocyte_attenuator required for association with protein tyrosine phosphatases SHP-1 and SHP-2 .
20582921	0	phosphotyrosine	97,112	SHP-1	179,184	phosphotyrosine	SHP-1	CHEBI:74956	5777	Chemical	Gene	START_ENTITY|nmod|SH2-domain SH2-domain|nmod|END_ENTITY	Syntheses and activities of backbone-side chain cyclic_octapeptide ligands with N-functionalized phosphotyrosine for the N-terminal SH2-domain of the protein tyrosine phosphatase SHP-1 .
9148918	0	phosphotyrosine	8,23	SHP-1	139,144	phosphotyrosine	SHP-1	CHEBI:74956	5777	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	A novel phosphotyrosine motif with a critical amino_acid at position -2 for the SH2 domain-mediated activation of the tyrosine phosphatase SHP-1 .
9261115	2	phosphotyrosine	347,362	SHP-1	375,380	phosphotyrosine	SHP-1	CHEBI:74956	5777	Chemical	Gene	site|compound|START_ENTITY dephosphorylated|nmod|site dephosphorylated|nmod|phosphatase phosphatase|compound|END_ENTITY	Herein we show that Src isolated from human platelets and Jurkat T cells is preferentially dephosphorylated at its inhibitory phosphotyrosine site by the SHP-1 tyrosine phosphatase .
7854346	0	phosphotyrosine	46,61	SSTR1	26,31	phosphotyrosine	SSTR1	CHEBI:74956	6751	Chemical	Gene	coupled|xcomp|START_ENTITY coupled|nsubjpass|END_ENTITY	The somatostatin receptor SSTR1 is coupled to phosphotyrosine phosphatase activity in CHO-K1 cells .
7537362	0	phosphotyrosine	69,84	Shb	60,63	phosphotyrosine	Shb	CHEBI:74956	6461	Chemical	Gene	residues|amod|START_ENTITY END_ENTITY|nmod|residues	Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues , tyrosine kinase receptors and Src homology 3 domain proteins .
10749687	12	phosphotyrosine	2272,2287	Shc	2299,2302	phosphotyrosine	FAK	CHEBI:74956	5747	Chemical	Gene	residue|amod|START_ENTITY residue|nmod|END_ENTITY	With the use of glutathione_S-transferase fusion proteins containing Shc-SH2 , Grb2-SH2 , and Grb2 N-terminal and C-terminal SH3 domains , it was implied that the proline-rich region of Pyk2 -LRB- and FAK -RRB- binds to the N-terminal SH3 domain of Grb2 and that the phosphotyrosine residue of Shc binds to the SH2 domain of Grb2 .
7542744	0	phosphotyrosine	4,19	Shc	42,45	phosphotyrosine	Shc	CHEBI:74956	6464	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	The phosphotyrosine interaction domain of Shc binds an LXNPXY motif on the epidermal_growth_factor_receptor .
8524391	0	phosphotyrosine	40,55	Shc	74,77	phosphotyrosine	Shc	CHEBI:74956	6464	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Structure and ligand recognition of the phosphotyrosine binding domain of Shc .
8537337	0	phosphotyrosine	50,65	Shc	112,115	phosphotyrosine	Shc	CHEBI:74956	6464	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	The regions of the Fe65 protein homologous to the phosphotyrosine interaction/phosphotyrosine binding domain of Shc bind the intracellular domain of the Alzheimer 's amyloid precursor protein .
8537373	0	phosphotyrosine	97,112	Shc	132,135	phosphotyrosine	Shc	CHEBI:74956	6464	Chemical	Gene	START_ENTITY|dobj|domains domains|nmod|END_ENTITY	Binding affinities of tyrosine-phosphorylated peptides to the COOH-terminal SH2 and NH2-terminal phosphotyrosine binding domains of Shc .
8626723	0	phosphotyrosine	24,39	Shc	58,61	phosphotyrosine	Shc	CHEBI:74956	6464	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Interaction between the phosphotyrosine binding domain of Shc and the insulin_receptor is required for Shc phosphorylation by insulin in vivo .
8824262	0	phosphotyrosine	28,43	Shc	24,27	phosphotyrosine	Shc	CHEBI:74956	6464	Chemical	Gene	START_ENTITY|nsubj|roles roles|nmod|END_ENTITY	Functional roles of the Shc phosphotyrosine binding and Src homology 2 domains in insulin and epidermal growth factor signaling .
9058724	0	phosphotyrosine	82,97	Shc	116,119	phosphotyrosine	Shc	CHEBI:74956	20416(Tax:10090)	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	A tyrosine-phosphorylated protein of 140 kD is constitutively associated with the phosphotyrosine binding domain of Shc and the SH3 domains of Grb2 in acute_myeloid_leukemia cells .
10809671	0	phosphotyrosine	9,24	ShcA	4,8	phosphotyrosine	ShcA	CHEBI:74956	20416(Tax:10090)	Chemical	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	The ShcA phosphotyrosine docking protein sensitizes cardiovascular signaling in the mouse embryo .
21148430	0	phosphotyrosine	9,24	ShcA	4,8	phosphotyrosine	ShcA	CHEBI:74956	20416(Tax:10090)	Chemical	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	The ShcA phosphotyrosine docking protein uses distinct mechanisms to regulate myocyte and global heart function .
11163269	0	phosphotyrosine	28,43	ShcC	23,27	phosphotyrosine	ShcC	CHEBI:74956	53358	Chemical	Gene	proteins|compound|START_ENTITY proteins|compound|END_ENTITY	The mammalian ShcB and ShcC phosphotyrosine docking proteins function in the maturation of sensory and sympathetic neurons .
8662772	0	phosphotyrosine	51,66	ShcC	120,124	phosphotyrosine	ShcC	CHEBI:74956	53358	Chemical	Gene	domain|amod|START_ENTITY specificity|nmod|domain END_ENTITY|nsubj|specificity	Binding specificity and mutational analysis of the phosphotyrosine binding domain of the brain-specific adaptor protein ShcC .
7690989	0	phosphotyrosine	9,24	Stat91	36,42	phosphotyrosine	Stat91	CHEBI:74956	6772	Chemical	Gene	residue|compound|START_ENTITY residue|nmod|END_ENTITY	A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma .
7534299	0	phosphotyrosine	30,45	Syp	58,61	phosphotyrosine	Syp	CHEBI:74956	6855	Chemical	Gene	Involvement|nmod|START_ENTITY phosphatase|nsubj|Involvement phosphatase|dobj|END_ENTITY	Involvement of SH2-containing phosphotyrosine phosphatase Syp in erythropoietin receptor signal transduction pathways .
22996389	0	phosphotyrosine	22,37	c-Met	16,21	phosphotyrosine	c-Met	CHEBI:74956	4233	Chemical	Gene	sites|compound|START_ENTITY sites|amod|END_ENTITY	Dissociation of c-Met phosphotyrosine sites in human cells in response to mouse hepatocyte_growth_factor but not human hepatocyte_growth_factor : the possible roles of different amino_acids in different species .
2787757	0	phosphotyrosine	59,74	epidermal_growth_factor_receptor	122,154	phosphotyrosine	epidermal growth factor receptor	CHEBI:74956	407217(Tax:9913)	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	The 18 kDa cytosolic acid phosphatase from bovine live has phosphotyrosine phosphatase activity on the autophosphorylated epidermal_growth_factor_receptor .
7679612	0	phosphotyrosine	10,25	epidermal_growth_factor_receptor	36,68	phosphotyrosine	epidermal growth factor receptor	CHEBI:74956	1956	Chemical	Gene	modulates|compound|START_ENTITY END_ENTITY|nsubj|modulates	Exogenous phosphotyrosine modulates epidermal_growth_factor_receptor tyrosine phosphorylation .
14668342	0	phosphotyrosine	85,100	insulin_receptor_substrate-1	119,147	phosphotyrosine	insulin receptor substrate-1	CHEBI:74956	3667	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	A highly conserved NTRK3 C-terminal sequence in the ETV6-NTRK3 oncoprotein binds the phosphotyrosine binding domain of insulin_receptor_substrate-1 : an essential interaction for transformation .
7678546	0	phosphotyrosine	142,157	p185	122,126	phosphotyrosine	p185	CHEBI:74956	8661	Chemical	Gene	content|amod|START_ENTITY END_ENTITY|nmod|content	Repression of neu-induced clonogenicity by dimethylsulfoxide correlates with decreased levels of neu-encoded cell-surface p185 and changes in phosphotyrosine content of endogenous proteins .
7537382	0	phosphotyrosine	9,24	prolactin_receptor	40,58	phosphotyrosine	prolactin receptor	CHEBI:74956	5618	Chemical	Gene	residue|compound|START_ENTITY residue|nmod|END_ENTITY	A single phosphotyrosine residue of the prolactin_receptor is responsible for activation of gene transcription .
24825902	0	phosphotyrosines	24,40	EphA2	59,64	phosphotyrosines	EphA2	null	1943	Chemical	Gene	START_ENTITY|nmod|receptor receptor|appos|END_ENTITY	Binding and function of phosphotyrosines of the Ephrin_A2 -LRB- EphA2 -RRB- receptor using synthetic sterile a motif -LRB- SAM -RRB- domains .
19289054	0	phosphotyrosyl	100,114	epidermal_growth_factor_receptor	127,159	phosphotyrosyl	epidermal growth factor receptor	null	1956	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Molecular dynamics simulations reveal that Tyr-317 phosphorylation reduces Shc binding affinity for phosphotyrosyl residues of epidermal_growth_factor_receptor .
21227907	0	phthalate	10,19	constitutive_androstane_receptor	60,92	phthalate	constitutive androstane receptor	MESH:C032279	9970	Chemical	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Selective phthalate activation of naturally occurring human constitutive_androstane_receptor splice variants and the pregnane_X_receptor .
27036411	3	phthalate	633,642	men	666,669	phthalate	MBP	MESH:C032279	4155	Chemical	Gene	metabolites|amod|START_ENTITY metabolites|nmod|END_ENTITY	Analyzed data for 12 phthalate metabolites from 3,746 men -LRB- > = 20 years old -RRB- , who participated in the National Health and Nutrition Examination Survey 2001-2004 cross-sectional study , were included .
12805656	0	phthalate_monoesters	55,75	PPARalpha	14,23	phthalate monoesters	PPARalpha	null	5465	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of PPARalpha and PPARgamma by environmental phthalate_monoesters .
19786001	0	phthalates	100,110	11beta-hydroxysteroid_dehydrogenase_2	48,85	phthalates	11beta-hydroxysteroid dehydrogenase 2	CHEBI:26092	25117(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|activities activities|amod|END_ENTITY	Structure-dependent inhibition of human and rat 11beta-hydroxysteroid_dehydrogenase_2 activities by phthalates .
18289850	0	phthalates	37,47	Cathepsin_B	0,11	phthalates	Cathepsin B	CHEBI:26092	13030(Tax:10090)	Chemical	Gene	activities|nmod|START_ENTITY activities|amod|END_ENTITY	Cathepsin_B inhibitory activities of phthalates isolated from a marine Pseudomonas strain .
26998565	0	phthalic_anhydride	62,80	IL-4	84,88	phthalic anhydride	IL-4	MESH:C043103	16189(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|transgenic_mice transgenic_mice|compound|END_ENTITY	Diosgenin effectively suppresses skin_inflammation induced by phthalic_anhydride in IL-4 / Luc/CNS -1 transgenic_mice .
12729831	0	phthalimide	62,73	Tumor_necrosis_factor-alpha	0,27	phthalimide	Tumor necrosis factor-alpha	MESH:C037431	21926(Tax:10090)	Chemical	Gene	derivatives|amod|START_ENTITY activity|nmod|derivatives activity|amod|END_ENTITY	Tumor_necrosis_factor-alpha production-regulating activity of phthalimide derivatives in genetically modified murine melanoma cells B78H1 .
9416426	0	phthalimide	62,73	Tumor_necrosis_factor-alpha	0,27	phthalimide	Tumor necrosis factor-alpha	MESH:C037431	7124	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Tumor_necrosis_factor-alpha production-inhibiting activity of phthalimide analogues on human leukemia THP-1 cells and a structure-activity relationship study .
27017111	0	phthalimide	43,54	acetylcholinesterase	70,90	phthalimide	acetylcholinesterase	MESH:C037431	43	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Design , synthesis and bioactivity of novel phthalimide derivatives as acetylcholinesterase inhibitors .
7796053	0	phthalimide	103,114	leukocyte_elastase	190,208	phthalimide	leukocyte elastase	MESH:C037431	1991	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|inhibitors inhibitors|nmod|END_ENTITY	The Gabriel-Colman rearrangement in biological systems : design , synthesis and biological evaluation of phthalimide and saccharin derivatives as potential mechanism-based inhibitors of human leukocyte_elastase , cathepsin_G_and_proteinase_3 .
9084226	0	phthalimides	38,50	TNF-alpha	56,65	phthalimides	TNF-alpha	MESH:D010797	7124	Chemical	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	-LSB- Novel biological response modifiers : phthalimides with TNF-alpha production regulating activity -RSB- .
9288167	0	phthalimides	37,49	tumor_necrosis_factor-alpha	55,82	phthalimides	tumor necrosis factor-alpha	MESH:D010797	7124	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Novel biological response modifiers : phthalimides with tumor_necrosis_factor-alpha production-regulating activity .
1597127	0	physostigmine	71,84	Acetylcholinesterase	0,20	physostigmine	Acetylcholinesterase	MESH:D010830	100422792	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Acetylcholinesterase inhibition and anti-soman efficacy of homologs of physostigmine .
12785467	0	physostigmine	37,50	Growth_hormone	0,14	physostigmine	Growth hormone	MESH:D010830	2688	Chemical	Gene	administration|compound|START_ENTITY responses|nmod|administration responses|amod|END_ENTITY	Growth_hormone responses to low-dose physostigmine administration : functional sex differences -LRB- sexual diergism -RRB- between major depressives and matched controls .
15582025	0	physostigmine	62,75	acetylcholinesterase	25,45	physostigmine	acetylcholinesterase	MESH:D010830	11423(Tax:10090)	Chemical	Gene	changes|nmod|START_ENTITY changes|nmod|inhibition inhibition|amod|END_ENTITY	Behavioral changes after acetylcholinesterase inhibition with physostigmine in mice .
15611638	0	physostigmine	42,55	acetylcholinesterase	88,108	physostigmine	acetylcholinesterase	MESH:D010830	43	Chemical	Gene	utilizing|dobj|START_ENTITY utilizing|advcl|detect detect|dobj|END_ENTITY	Novel assay utilizing fluorochrome-tagged physostigmine -LRB- Ph-F -RRB- to in situ detect active acetylcholinesterase -LRB- AChE -RRB- induced during apoptosis .
1676644	0	physostigmine	144,157	acetylcholinesterase	74,94	physostigmine	acetylcholinesterase	MESH:D010830	43	Chemical	Gene	release|nmod|START_ENTITY physostigmine|nmod|release physostigmine|dobj|concentrations concentrations|nmod|inhibition inhibition|amod|END_ENTITY	Correlation between plasma physostigmine concentrations and percentage of acetylcholinesterase inhibition over time after controlled release of physostigmine in volunteer subjects .
1676644	0	physostigmine	27,40	acetylcholinesterase	74,94	physostigmine	acetylcholinesterase	MESH:D010830	43	Chemical	Gene	START_ENTITY|dobj|concentrations concentrations|nmod|inhibition inhibition|amod|END_ENTITY	Correlation between plasma physostigmine concentrations and percentage of acetylcholinesterase inhibition over time after controlled release of physostigmine in volunteer subjects .
19283689	0	physostigmine	134,147	acetylcholinesterase	32,52	physostigmine	acetylcholinesterase	MESH:D010830	83817(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Differential mRNA expression of acetylcholinesterase in the central nervous system of rats with acute and chronic exposure of sarin _ physostigmine .
1955905	0	physostigmine	152,165	acetylcholinesterase	20,40	physostigmine	acetylcholinesterase	MESH:D010830	43	Chemical	Gene	relative|nmod|START_ENTITY END_ENTITY|dep|relative	Cerebrospinal fluid acetylcholinesterase in progressive_supranuclear_palsy : reduced activity relative to normal subjects and lack of inhibition by oral physostigmine .
21402092	0	physostigmine	34,47	acetylcholinesterase	96,116	physostigmine	acetylcholinesterase	MESH:D010830	43	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nsubj|effect	Pre - and post-treatment effect of physostigmine on soman-inhibited human erythrocyte and muscle acetylcholinesterase in vitro .
2293100	0	physostigmine	18,31	acetylcholinesterase	48,68	physostigmine	acetylcholinesterase	MESH:D010830	43	Chemical	Gene	Tremorogenesis|nmod|START_ENTITY unrelated|nsubj|Tremorogenesis unrelated|xcomp|END_ENTITY	Tremorogenesis by physostigmine is unrelated to acetylcholinesterase inhibition : evidence for serotoninergic involvement .
2922758	0	physostigmine	38,51	acetylcholinesterase	61,81	physostigmine	acetylcholinesterase	MESH:D010830	83817(Tax:10116)	Chemical	Gene	administration|nmod|START_ENTITY Effects|nmod|administration END_ENTITY|nsubj|Effects	Effects of subacute administration of physostigmine on blood acetylcholinesterase activity , motor performance , and soman intoxication .
3178795	0	physostigmine	42,55	acetylcholinesterase	14,34	physostigmine	acetylcholinesterase	MESH:D010830	43	Chemical	Gene	derivatives|compound|START_ENTITY Inhibition|nmod|derivatives Inhibition|nmod|END_ENTITY	Inhibition of acetylcholinesterase by new physostigmine derivatives .
3785584	0	physostigmine	15,28	acetylcholinesterase	32,52	physostigmine	acetylcholinesterase	MESH:D010830	489828(Tax:9615)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	The effects of physostigmine on acetylcholinesterase activity of CSF plasma and brain .
9568379	0	physostigmine	109,122	acetylcholinesterase	71,91	physostigmine	acetylcholinesterase	MESH:D010830	43	Chemical	Gene	carbamylation|nmod|START_ENTITY carbamylation|amod|END_ENTITY	Effects of hexamethonium , phenothiazines , propranolol and ephedrine on acetylcholinesterase carbamylation by physostigmine , aldicarb and carbaryl : interaction between the active site and the functionally distinct peripheral sites in acetylcholinesterase .
9675107	0	physostigmine	87,100	acetylcholinesterase	30,50	physostigmine	acetylcholinesterase	MESH:D010830	43	Chemical	Gene	derivative|nmod|START_ENTITY END_ENTITY|nmod|derivative	Kinetics of human erythrocyte acetylcholinesterase inhibition by a novel derivative of physostigmine : phenserine .
15913750	0	physostigmine	11,24	butyrylcholinesterase	35,56	physostigmine	butyrylcholinesterase	MESH:D010830	590	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of physostigmine and human butyrylcholinesterase on acoustic startle reflex and prepulse inhibition in C57BL/6J mice .
978479	0	physostigmine	15,28	cholinesterase	32,46	physostigmine	cholinesterase	MESH:D010830	395358(Tax:9031)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activity activity|amod|END_ENTITY	The effects of physostigmine on cholinesterase activity , storage and release of acetylcholine in the isolated chicken heart .
24870784	0	phytic_acid	10,21	Bax	68,71	phytic acid	Bax	MESH:D010833	581	Chemical	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Rice bran phytic_acid induced apoptosis through regulation of Bcl-2 / Bax and p53 genes in HepG2 human hepatocellular_carcinoma cells .
23285696	0	phytic_acid	14,25	NF-kappaB	47,56	phytic acid	NF-kappaB	MESH:D010833	4790	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	The effect of phytic_acid on the expression of NF-kappaB , IL-6 and IL-8 in IL-1beta-stimulated human colonic epithelial cells .
15840570	0	phytochelatin	20,33	CeHMT-1	0,7	phytochelatin	CeHMT-1	MESH:D054811	176540(Tax:6239)	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|appos|transporter	CeHMT-1 , a putative phytochelatin transporter , is required for cadmium tolerance in Caenorhabditis_elegans .
12771320	0	phytosterol_esters	145,163	cholesteryl_ester_transfer_protein	10,44	phytosterol esters	cholesteryl ester transfer protein	null	1071	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|polymorphism polymorphism|compound|END_ENTITY	The human cholesteryl_ester_transfer_protein I405V polymorphism is associated with plasma cholesterol concentration and its reduction by dietary phytosterol_esters .
26408181	0	piR-55490	0,9	mTOR	63,67	piR-55490	mTOR	null	21977(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	piR-55490 inhibits the growth of lung_carcinoma by suppressing mTOR signaling .
24610083	0	piceatannol	47,58	CYP17A1	14,21	piceatannol	CYP17A1	MESH:C041525	1586	Chemical	Gene	activity|nmod|START_ENTITY activity|nummod|END_ENTITY	Inhibition of CYP17A1 activity by resveratrol , piceatannol , and synthetic resveratrol analogs .
19356012	0	piceatannol	48,59	CYP1A1	27,33	piceatannol	CYP1A1	MESH:C041525	24296(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	In vitro inhibition of rat CYP1A1 and CYP1A2 by piceatannol , a hydroxylated metabolite of trans-resveratrol .
10777558	1	piceatannol	127,138	STAT3	108,113	piceatannol	STAT3	MESH:C041525	6774	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Selective inhibition of STAT3 and STAT5 by piceatannol .
23712764	0	piceatannol	65,76	heme_oxygenase-1	15,31	piceatannol	heme oxygenase-1	MESH:C041525	3162	Chemical	Gene	neuroprotection|nmod|START_ENTITY expression|nmod|neuroprotection expression|amod|END_ENTITY	Involvement of heme_oxygenase-1 expression in neuroprotection by piceatannol , a natural analog and a metabolite of resveratrol , against glutamate-mediated oxidative injury in HT22 neuronal cells .
25815690	0	piceatannol	19,30	heme_oxygenase-1	195,211	piceatannol	heme oxygenase-1	MESH:C041525	3162	Chemical	Gene	restores|nsubj|START_ENTITY restores|dobj|signaling signaling|nmod|nitric_oxide nitric_oxide|nmod|activation activation|nmod|END_ENTITY	Resveratrol analog piceatannol restores the palmitic_acid-induced impairment_of_insulin signaling and production of endothelial nitric_oxide via activation of anti-inflammatory and antioxidative heme_oxygenase-1 in human endothelial cells .
12718941	0	picolinic_acid	23,37	macrophage_inflammatory_protein-1alpha	62,100	picolinic acid	macrophage inflammatory protein-1alpha	MESH:C030614	20302(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|production production|amod|END_ENTITY	Antagonistic effect of picolinic_acid and interferon-gamma on macrophage_inflammatory_protein-1alpha / beta production .
2990522	0	picolinic_acid	25,39	transferrin	49,60	picolinic acid	transferrin	MESH:C030614	7018	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	The iron-chelating agent picolinic_acid enhances transferrin receptors expression in human erythroleukaemic cell lines .
24002245	0	picrasmalignan_A	37,53	iNOS	75,79	picrasmalignan A	iNOS	MESH:C561749	18126(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	In vitro anti-inflammatory effect of picrasmalignan_A by the inhibition of iNOS and COX __ -2 expression in LPS - activated macrophage RAW 264.7 cells .
23699657	0	picropodophyllin	65,81	IGF-IR	48,54	picropodophyllin	IGF-IR	MESH:C415032	3480	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|inhibitor inhibitor|compound|END_ENTITY	Alternative cytotoxic effects of the postulated IGF-IR inhibitor picropodophyllin in vitro .
18515591	0	picropodophyllin	78,94	insulin-like_growth_factor-1_receptor	122,159	picropodophyllin	insulin-like growth factor-1 receptor	MESH:C415032	3480	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Inhibition of VEGF secretion and experimental choroidal_neovascularization by picropodophyllin -LRB- PPP -RRB- , an inhibitor of the insulin-like_growth_factor-1_receptor .
19032681	0	picropodophyllin	78,94	insulin-like_growth_factor-1_receptor	122,159	picropodophyllin	insulin-like growth factor-1 receptor	MESH:C415032	3480	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Inhibition of VEGF secretion and experimental choroidal_neovascularization by picropodophyllin -LRB- PPP -RRB- , an inhibitor of the insulin-like_growth_factor-1_receptor .
9612852	0	picrotoxin	99,109	CA1	117,120	picrotoxin	CA1	MESH:D010852	310218(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|region region|compound|END_ENTITY	-LSB- Selective suppression of the direct and feedback `` fast '' inhibition during local administration of picrotoxin in the CA1 region of rat hippocampal slices -RSB- .
8635557	0	picrotoxin	73,83	Fos	23,26	picrotoxin	Fos	MESH:D010852	2353	Chemical	Gene	expression|nmod|START_ENTITY END_ENTITY|dep|expression	Pentobarbitone induces Fos in astrocytes : increased expression following picrotoxin and seizures .
26291498	0	pifithrin-a	19,30	p53	4,7	pifithrin-a	p53	null	100136737(Tax:8022)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	The p53 inhibitor , pifithrin-a , disrupts microtubule organization , arrests growth , and induces polyploidy in the rainbow_trout gill cell line , RTgill-W1 .
24997826	0	piglitazone	10,21	retinol-binding_protein-4	39,64	piglitazone	retinol-binding protein-4	null	5950	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of piglitazone and metformin on retinol-binding_protein-4 and adiponcetin in patients with type_2_diabetes_mellitus complicated with non-alcohol fatty acid liver_diseases .
17178767	0	pilocarpine	89,100	CYP2A6	15,21	pilocarpine	CYP2A6	MESH:D010862	1548	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of CYP2A6 in the formation of a novel metabolite , 3-hydroxypilocarpine , from pilocarpine in human liver microsomes .
842358	0	pilocarpine	92,103	Choline_acetyltransferase	0,25	pilocarpine	Choline acetyltransferase	MESH:D010862	290567(Tax:10116)	Chemical	Gene	treatment|nmod|START_ENTITY END_ENTITY|nmod|treatment	Choline_acetyltransferase activity in parotid glands of rats after prolonged treatment with pilocarpine .
19673936	0	pilocarpine	24,35	aquaporin-5	45,56	pilocarpine	aquaporin-5	MESH:D010862	25241(Tax:10116)	Chemical	Gene	triggered|nmod|START_ENTITY Salivation|acl|triggered involves|nsubj|Salivation involves|xcomp|END_ENTITY	Salivation triggered by pilocarpine involves aquaporin-5 in normal rats but not in irradiated rats .
24610966	0	pilocarpine	38,49	aquaporin-5	71,82	pilocarpine	aquaporin-5	MESH:D010862	25241(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|amod|END_ENTITY	Effects of repeated administration of pilocarpine and isoproterenol on aquaporin-5 expression in rat salivary glands .
26961147	0	pimasertib	33,43	BTK	49,52	pimasertib	BTK	MESH:C550600	695	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Combination of the MEK inhibitor pimasertib with BTK or PI3K-delta inhibitors is active in pre-clinical models of aggressive_lymphomas .
391168	0	pimozide	10,18	LH-RH	38,43	pimozide	LH-RH	MESH:D010868	25194(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|response response|nmod|END_ENTITY	Effect of pimozide on the response of LH-RH in intact adult male rats .
993322	0	pimozide	47,55	growth_hormone	63,77	pimozide	growth hormone	MESH:D010868	2688	Chemical	Gene	START_ENTITY|nmod|response response|amod|END_ENTITY	Effect of the dopamine receptor blocking agent pimozide on the growth_hormone response to arginine and exercise and on the spontaneous growth_hormone fluctuations .
4041067	0	pimozide	11,19	prolactin	54,63	pimozide	prolactin	MESH:D010868	24683(Tax:10116)	Chemical	Gene	administration|amod|START_ENTITY administration|nmod|levels levels|compound|END_ENTITY	Effects of pimozide and domperidone administration on prolactin levels in neonatally estrogenized female rats .
7093595	0	pimozide	74,82	prolactin	7,16	pimozide	prolactin	MESH:D010868	5617	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|END_ENTITY	Plasma prolactin and growth_hormone levels in manic patients treated with pimozide .
2189901	0	pinacidil	34,43	insulin	47,54	pinacidil	insulin	MESH:D020110	3630	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Lack of effect of the vasodilator pinacidil on insulin secretion in healthy humans .
7608319	0	pinacidil	40,49	insulin	53,60	pinacidil	insulin	MESH:D020110	3630	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	Potassium channel modulation : effect of pinacidil on insulin release in healthy volunteers .
8736460	0	pinacidil	70,79	insulin	20,27	pinacidil	insulin	MESH:D020110	3630	Chemical	Gene	START_ENTITY|nsubj|deterioration deterioration|nmod|secretion secretion|compound|END_ENTITY	No deterioration of insulin secretion by the potassium channel opener pinacidil in essential hypertension .
3055428	0	pinacolyl_methylphosphonofluoridate	46,81	acetylcholinesterase	15,35	pinacolyl methylphosphonofluoridate	acetylcholinesterase	MESH:D012999	83817(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Effects of the acetylcholinesterase inhibitor pinacolyl_methylphosphonofluoridate -LRB- soman -RRB- on selected endocrine , glucose , and catecholamine levels in fasted and fed rats .
15127080	0	pindolol	46,54	5-HT1A	13,19	pindolol	5-HT1A	MESH:D010869	3350	Chemical	Gene	occupancy|nmod|START_ENTITY occupancy|amod|END_ENTITY	Preferential 5-HT1A autoreceptor occupancy by pindolol is attenuated in depressed patients : effect of treatment or an endophenotype of depression ?
8471832	0	pindolol	49,57	Prolactin	0,9	pindolol	Prolactin	MESH:D010869	5617	Chemical	Gene	administration|amod|START_ENTITY responses|nmod|administration responses|compound|END_ENTITY	Prolactin and thyrotropin responses to ECT after pindolol administration .
14533141	0	pindolol	10,18	prolactin	76,85	pindolol	prolactin	MESH:D010869	5617	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of pindolol and milnacipran versus milnacipran and placebo on plasma prolactin and adrenocorticotrophic hormone in depressed subjects .
7568634	0	pindolol	10,18	prolactin	26,35	pindolol	prolactin	MESH:D010869	5617	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|response response|compound|END_ENTITY	Effect of pindolol on the prolactin response to d-fenfluramine .
7855226	0	pindolol	10,18	prolactin	61,70	pindolol	prolactin	MESH:D010869	5617	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|increase increase|nmod|END_ENTITY	Effect of pindolol on the L-5-HTP-induced increase in plasma prolactin and cortisol concentrations in man .
1215927	0	pindolol	57,65	renin	80,85	pindolol	renin	MESH:D010869	5972	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	-LSB- Proceedings : The effect of beta receptor treatment with pindolol on the plasma renin activity and the left-ventricular dynamics in essential hypertension -RSB- .
411662	0	pindolol	14,22	renin	33,38	pindolol	renin	MESH:D010869	5972	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|compound|END_ENTITY	The effect of pindolol on plasma renin activity in patients with essential hypertension .
6102616	1	pindolol	104,112	renin	116,121	pindolol	renin	MESH:D010869	24715(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	Effects of dl - , d - , _ l-propranolol and pindolol on renin release .
6360452	0	pindolol	10,18	renin	45,50	pindolol	renin	MESH:D010869	5972	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of pindolol and propranolol on plasma renin and aldosterone in patients with renal allograft .
973972	0	pindolol	14,22	renin	33,38	pindolol	renin	MESH:D010869	5972	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|compound|END_ENTITY	The effect of pindolol on plasma renin activity and blood pressure in hypertensive patients .
26645404	0	pinometostat	51,63	DOT1L	34,39	pinometostat	DOT1L	null	362831(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Metabolism and disposition of the DOT1L inhibitor , pinometostat -LRB- EPZ-5676 -RRB- , in rat , dog and human .
23333577	0	pinosylvin	56,66	b-catenin	33,42	pinosylvin	b-catenin	MESH:C049032	1499	Chemical	Gene	signaling|nmod|START_ENTITY signaling|amod|END_ENTITY	Suppression of Src/ERK and GSK-3 / b-catenin signaling by pinosylvin inhibits the growth of human colorectal_cancer cells .
18664597	0	pioglitazone	38,50	Adiponectin	0,11	pioglitazone	Adiponectin	MESH:C060836	9370	Chemical	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Adiponectin secretion and response to pioglitazone is depot dependent in cultured human adipose_tissue .
12915698	0	pioglitazone	59,71	BNP	7,10	pioglitazone	BNP	MESH:C060836	4879	Chemical	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	Plasma BNP levels in the treatment of type 2 diabetes with pioglitazone .
25964889	0	pioglitazone	10,22	C-reactive_protein	49,67	pioglitazone	C-reactive protein	MESH:C060836	1401	Chemical	Gene	therapy|amod|START_ENTITY therapy|nmod|END_ENTITY	Effect of pioglitazone therapy on high sensitive C-reactive_protein and lipid profile in diabetic patients with renal transplantation ; a randomize clinical trial .
25210844	0	pioglitazone	11,23	CIDEC	57,62	pioglitazone	CIDEC	MESH:C060836	14311(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY mediated|nsubj|Effects mediated|nmod|END_ENTITY	Effects of pioglitazone mediated activation of PPAR-y on CIDEC and obesity related changes in mice .
19614891	0	pioglitazone	48,60	CYP2C8	18,24	pioglitazone	CYP2C8	MESH:C060836	1558	Chemical	Gene	metabolism|amod|START_ENTITY variants|nmod|metabolism variants|nsubj|role role|nmod|END_ENTITY	The role of human CYP2C8 and CYP2C9 variants in pioglitazone metabolism in vitro .
23712614	0	pioglitazone	49,61	CYP2C8	13,19	pioglitazone	CYP2C8	MESH:C060836	1558	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY *|nmod|pharmacokinetics *|nsubj|Influence Influence|nmod|END_ENTITY	Influence of CYP2C8 * 2 on the pharmacokinetics of pioglitazone in healthy African-American volunteers .
26195223	0	pioglitazone	54,66	CYP2C8	147,153	pioglitazone	CYP2C8	MESH:C060836	1558	Chemical	Gene	interaction|nmod|START_ENTITY mechanism|nmod|interaction Underlying|dobj|mechanism Underlying|parataxis|inhibitor inhibitor|nmod|END_ENTITY	Underlying mechanism of drug-drug interaction between pioglitazone and gemfibrozil : Gemfibrozil_acyl-glucuronide is a mechanism-based inhibitor of CYP2C8 .
26195223	0	pioglitazone	54,66	CYP2C8	147,153	pioglitazone	CYP2C8	MESH:C060836	1558	Chemical	Gene	interaction|nmod|START_ENTITY mechanism|nmod|interaction Underlying|dobj|mechanism Underlying|parataxis|inhibitor inhibitor|nmod|END_ENTITY	Underlying mechanism of drug-drug interaction between pioglitazone and gemfibrozil : Gemfibrozil_acyl-glucuronide is a mechanism-based inhibitor of CYP2C8 .
21036144	0	pioglitazone	99,111	GPR40	25,30	pioglitazone	GPR40	MESH:C060836	2864	Chemical	Gene	relationship|nmod|START_ENTITY relationship|nmod|END_ENTITY	The relationship between GPR40 and lipotoxicity of the pancreatic b-cells as well as the effect of pioglitazone .
21514683	0	pioglitazone	10,22	HIF-1a	65,71	pioglitazone	HIF-1a	MESH:C060836	29560(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of pioglitazone on diabetic_nephropathy and expression of HIF-1a and VEGF in the renal tissues of type 2 diabetic rats .
11411343	0	pioglitazone	75,87	Insulin	1,8	pioglitazone	Insulin	MESH:C060836	483665(Tax:9615)	Chemical	Gene	-RSB-|amod|START_ENTITY effect|nmod|-RSB- resistance-reducing|dobj|effect resistance-reducing|nsubj|END_ENTITY	-LSB- Insulin resistance-reducing effect of a new thiazolidinedione derivative , pioglitazone -RSB- .
16334613	0	pioglitazone	44,56	Insulin	0,7	pioglitazone	Insulin	MESH:C060836	3630	Chemical	Gene	treatment|amod|START_ENTITY predictor|nmod|treatment index|nmod|predictor index|compound|END_ENTITY	Insulin resistance index as a predictor for pioglitazone treatment in type 2 diabetes .
17063547	0	pioglitazone	12,24	MKP-1	28,33	pioglitazone	MKP-1	MESH:C060836	114856(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|amod|END_ENTITY	-LSB- Effects of pioglitazone on MKP-1 and TSP-1 expression in early stages of diabetic_retinopathy induced by streptozotocin -RSB- .
20392866	0	pioglitazone	87,99	Matrix_metalloproteinase-9	0,26	pioglitazone	Matrix metalloproteinase-9	MESH:C060836	4318	Chemical	Gene	increased|xcomp|START_ENTITY increased|nsubjpass|END_ENTITY	Matrix_metalloproteinase-9 is increased in obese subjects and decreases in response to pioglitazone .
20414637	0	pioglitazone	79,91	PPAR	59,63	pioglitazone	PPAR	MESH:C060836	5465	Chemical	Gene	Effects|dep|START_ENTITY Effects|nmod|peroxisome_proliferator-activated_receptor peroxisome_proliferator-activated_receptor|appos|END_ENTITY	Effects of the peroxisome_proliferator-activated_receptor -LRB- PPAR -RRB- - gamma agonist pioglitazone on renal and hormonal responses to salt in diabetic and hypertensive individuals .
12610044	7	pioglitazone	1491,1503	PPAR-gamma	1435,1445	pioglitazone	PPAR-gamma	MESH:C060836	5468	Chemical	Gene	efficacy|nmod|START_ENTITY affect|dobj|efficacy affect|nsubj|variant variant|nmod|gene gene|amod|END_ENTITY	CONCLUSIONS : The Pro12Ala variant in the PPAR-gamma gene does not affect the therapy efficacy of pioglitazone , suggesting that the drug-treatment response is independent from pharmacogenetic effects between PPAR-gamma and its ligand pioglitazone .
12688526	0	pioglitazone	81,93	PPAR-gamma	61,71	pioglitazone	PPAR-gamma	MESH:C060836	25664(Tax:10116)	Chemical	Gene	ligand|advmod|START_ENTITY ligand|nsubj|peroxisome_proliferator-activated_receptor-gamma peroxisome_proliferator-activated_receptor-gamma|appos|END_ENTITY	A specific peroxisome_proliferator-activated_receptor-gamma -LRB- PPAR-gamma -RRB- ligand , pioglitazone , ameliorates gastric_mucosal_damage induced by ischemia and reperfusion in rats .
12732191	0	pioglitazone	91,103	PPAR-gamma	112,122	pioglitazone	PPAR-gamma	MESH:C060836	19016(Tax:10090)	Chemical	Gene	increased|nmod|START_ENTITY increased|nmod|END_ENTITY	Lipoprotein_lipase mRNA in white_adipose_tissue but not in skeletal muscle is increased by pioglitazone through PPAR-gamma .
12821117	0	pioglitazone	118,130	PPAR-gamma	0,10	pioglitazone	PPAR-gamma	MESH:C060836	5468	Chemical	Gene	suppresses|nmod|START_ENTITY suppresses|nsubj|overexpression overexpression|amod|END_ENTITY	PPAR-gamma overexpression suppresses glucose-induced proinsulin biosynthesis and insulin release synergistically with pioglitazone in MIN6 cells .
15721871	0	pioglitazone	33,45	PPAR-gamma	15,25	pioglitazone	PPAR-gamma	MESH:C060836	25664(Tax:10116)	Chemical	Gene	ligand|dobj|START_ENTITY ligand|nsubj|effects effects|nmod|END_ENTITY	The effects of PPAR-gamma ligand pioglitazone on platelet_aggregation and arterial thrombus formation .
15738655	0	pioglitazone	23,35	PPAR-gamma	4,14	pioglitazone	PPAR-gamma	MESH:C060836	5468	Chemical	Gene	post-transcriptionally|compound|START_ENTITY post-transcriptionally|amod|END_ENTITY	The PPAR-gamma agonist pioglitazone post-transcriptionally induces p21 in PC3 prostate_cancer but not in other cell lines .
16876172	0	pioglitazone	23,35	PPAR-gamma	4,14	pioglitazone	PPAR-gamma	MESH:C060836	5468	Chemical	Gene	increases|compound|START_ENTITY increases|amod|END_ENTITY	The PPAR-gamma agonist pioglitazone increases neoangiogenesis and prevents apoptosis of endothelial progenitor cells .
17141574	0	pioglitazone	43,55	PPAR-gamma	23,33	pioglitazone	PPAR-gamma	MESH:C060836	25664(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Long-term effects of a PPAR-gamma agonist , pioglitazone , on neointimal hyperplasia and endothelial regrowth in insulin resistant rats .
17593822	0	pioglitazone	18,30	PPAR-gamma	42,52	pioglitazone	PPAR-gamma	MESH:C060836	5468	Chemical	Gene	START_ENTITY|xcomp|activating activating|dobj|END_ENTITY	-LSB- Effect of ligand pioglitazone activating PPAR-gamma on the invasiveness of cholangiocarcinoma cell in vitro and the expression regulation of related genes -RSB- .
19286954	0	pioglitazone	18,30	PPAR-gamma	68,78	pioglitazone	PPAR-gamma	MESH:C060836	100008892(Tax:9986)	Chemical	Gene	protects|nsubj|START_ENTITY protects|dobj|heart heart|nmod|activation activation|nmod|receptors receptors|amod|END_ENTITY	Antidiabetic drug pioglitazone protects the heart via activation of PPAR-gamma receptors , PI3-kinase , Akt , and eNOS pathway in a rabbit model of myocardial_infarction .
15644937	0	pioglitazone	46,58	PPAR_gamma	25,35	pioglitazone	PPAR gamma	MESH:C060836	25664(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|activator activator|compound|END_ENTITY	Long-term effects of the PPAR_gamma activator pioglitazone on cardiac_inflammation in stroke-prone spontaneously hypertensive rats .
15052691	0	pioglitazone	25,37	PPARg	11,16	pioglitazone	PPARg	MESH:C060836	25664(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|agonist agonist|compound|END_ENTITY	Effects of PPARg agonist pioglitazone on rat hepatic fibrosis .
15841215	0	pioglitazone	33,45	PPARgamma	15,24	pioglitazone	PPARgamma	MESH:C060836	5468	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|agonist agonist|compound|END_ENTITY	Effects of the PPARgamma agonist pioglitazone on lipoprotein metabolism in patients with type_2_diabetes_mellitus .
18312546	0	pioglitazone	35,47	PPARgamma	15,24	pioglitazone	PPARgamma	MESH:C060836	19016(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|activator activator|compound|END_ENTITY	Effects of the PPARgamma activator pioglitazone on p38 MAP kinase and IkappaBalpha in the spinal cord of a transgenic mouse model of amyotrophic_lateral_sclerosis .
18557423	0	pioglitazone	42,54	PPARgamma	24,33	pioglitazone	PPARgamma	MESH:C060836	100008892(Tax:9986)	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|agonist agonist|compound|END_ENTITY	Protective effects of a PPARgamma agonist pioglitazone on anti-oxidative system in testis of diabetic rabbits .
19331671	0	pioglitazone	135,147	PPARgamma	117,126	pioglitazone	PPARgamma	MESH:C060836	25664(Tax:10116)	Chemical	Gene	START_ENTITY|dep|agonist agonist|compound|END_ENTITY	Different skeletal effects of the peroxisome proliferator activated receptor -LRB- PPAR -RRB- alpha agonist fenofibrate and the PPARgamma agonist pioglitazone .
19506796	0	pioglitazone	76,88	PPARgamma	24,33	pioglitazone	PPARgamma	MESH:C060836	5468	Chemical	Gene	activation|nmod|START_ENTITY activation|nsubj|effects effects|nmod|END_ENTITY	Differential effects of PPARgamma activation by the oral antidiabetic agent pioglitazone in Barrett 's _ carcinoma in vitro and in vivo .
19920213	0	pioglitazone	29,41	PPARgamma	142,151	pioglitazone	PPARgamma	MESH:C060836	19016(Tax:10090)	Chemical	Gene	preserves|nsubj|START_ENTITY mechanism|acl:relcl|preserves mechanism|dep|evidence evidence|nmod|agonist agonist|compound|END_ENTITY	Molecular mechanism by which pioglitazone preserves pancreatic beta-cells in obese diabetic mice : evidence for acute and chronic actions as a PPARgamma agonist .
21440606	0	pioglitazone	21,33	PPARy	37,42	pioglitazone	PPARy	MESH:C060836	5468	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Protective effect of pioglitazone , a PPARy ligand , in a 3 nitropropionic_acid model of Huntington 's _ disease .
21968139	0	pioglitazone	169,181	PPARy	62,67	pioglitazone	PPARy	MESH:C060836	5468	Chemical	Gene	treatment|nmod|START_ENTITY relation|nmod|treatment Polymorphism|dep|relation Polymorphism|nmod|Pro12Ala Pro12Ala|appos|END_ENTITY	Polymorphism of peroxisome_proliferator-activated_receptor_y -LRB- PPARy -RRB- Pro12Ala in the Iranian population : relation with insulin resistance and response to treatment with pioglitazone in type 2 diabetes .
24722496	0	pioglitazone	128,140	PPARy	16,21	pioglitazone	PPARy	MESH:C060836	5468	Chemical	Gene	effects|nmod|START_ENTITY improve|nmod|effects improve|nsubj|modulator modulator|compound|END_ENTITY	Can a selective PPARy modulator improve glycemic control in patients with type_2_diabetes with fewer side effects compared with pioglitazone ?
16461819	0	pioglitazone	65,77	Peroxisome_proliferator-activated_receptor-gamma	0,48	pioglitazone	Peroxisome proliferator-activated receptor-gamma	MESH:C060836	5468	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Peroxisome_proliferator-activated_receptor-gamma activation with pioglitazone improves endothelium-dependent dilation in nondiabetic patients with major cardiovascular risk factors .
24727234	0	pioglitazone	25,37	RAGE	72,76	pioglitazone	RAGE	MESH:C060836	101669765	Chemical	Gene	effects|nmod|START_ENTITY Comparison|nmod|effects END_ENTITY|nsubj|Comparison	Comparison of effects of pioglitazone and glimepiride on plasma soluble RAGE and RAGE expression in peripheral mononuclear cells in type 2 diabetes : randomized controlled trial -LRB- PioRAGE -RRB- .
26003726	0	pioglitazone	63,75	REST	79,83	pioglitazone	REST	MESH:C060836	5978	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of REST4 in human gliomas in vivo and influence of pioglitazone on REST in vitro .
23662393	0	pioglitazone	12,24	TGFbeta1	28,36	pioglitazone	TGFbeta1	MESH:C060836	59086(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effects of pioglitazone on TGFbeta1 expression in ischemia/reperfusion injury myocardium of rats -RSB- .
25108428	0	pioglitazone	11,23	TLR4	45,49	pioglitazone	TLR4	MESH:C060836	29260(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of pioglitazone on the expression of TLR4 in renal tissue of diabetic rats -RSB- .
17952841	0	pioglitazone	75,87	Visfatin	0,8	pioglitazone	Visfatin	MESH:C060836	10135	Chemical	Gene	treatment|compound|START_ENTITY influenced|nmod|treatment biomarker|dep|influenced END_ENTITY|dep|biomarker	Visfatin : a putative biomarker for metabolic_syndrome is not influenced by pioglitazone or simvastatin treatment in nondiabetic patients at cardiovascular risk -- results from the PIOSTAT study .
15056132	0	pioglitazone	64,76	adiponectin	13,24	pioglitazone	adiponectin	MESH:C060836	9370	Chemical	Gene	efficacy|nmod|START_ENTITY predicts|dobj|efficacy predicts|nsubj|concentration concentration|compound|END_ENTITY	Lower plasma adiponectin concentration predicts the efficacy of pioglitazone in diabetic patients .
16118250	0	pioglitazone	44,56	adiponectin	17,28	pioglitazone	adiponectin	MESH:C060836	9370	Chemical	Gene	response|nmod|START_ENTITY END_ENTITY|nmod|response	Increased plasma adiponectin in response to pioglitazone does not result from increased gene expression .
16682836	0	pioglitazone	38,50	adiponectin	12,23	pioglitazone	adiponectin	MESH:C060836	9370	Chemical	Gene	therapy|amod|START_ENTITY Increase|nmod|therapy Increase|nmod|levels levels|compound|END_ENTITY	Increase in adiponectin levels during pioglitazone therapy in relation to glucose control , insulin resistance as well as ghrelin and resistin levels .
16839832	0	pioglitazone	93,105	adiponectin	10,21	pioglitazone	adiponectin	MESH:C060836	9370	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|Effect Effect|nmod|END_ENTITY	Effect of adiponectin on carotid arterial stiffness in type 2 diabetic patients treated with pioglitazone and metformin .
17003306	0	pioglitazone	14,26	adiponectin	49,60	pioglitazone	adiponectin	MESH:C060836	9370	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|role role|nmod|END_ENTITY	The effect of pioglitazone on the liver : role of adiponectin .
17121522	0	pioglitazone	11,23	adiponectin	48,59	pioglitazone	adiponectin	MESH:C060836	9370	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of pioglitazone and metformin on plasma adiponectin in newly detected type_2_diabetes_mellitus .
17509067	0	pioglitazone	29,41	adiponectin	103,114	pioglitazone	adiponectin	MESH:C060836	9370	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|circulating circulating|dobj|END_ENTITY	Comparison of the effects of pioglitazone and voglibose on circulating total and high-molecular-weight adiponectin , and on two fibrinolysis inhibitors , in patients with Type 2 diabetes .
17803698	0	pioglitazone	112,124	adiponectin	38,49	pioglitazone	adiponectin	MESH:C060836	9370	Chemical	Gene	treatment|amod|START_ENTITY levels|nmod|treatment END_ENTITY|dobj|levels	Total and high molecular weight -LRB- HMW -RRB- adiponectin levels and measures of glucose and lipid metabolism following pioglitazone treatment in a randomized placebo-controlled study in polycystic_ovary_syndrome .
19545925	0	pioglitazone	9,21	adiponectin	60,71	pioglitazone	adiponectin	MESH:C060836	9370	Chemical	Gene	increases|compound|START_ENTITY serum|nsubj|increases serum|dobj|END_ENTITY	Low-dose pioglitazone increases serum high molecular weight adiponectin and improves glycemic control in Japanese patients with poorly controlled type 2 diabetes .
22187345	0	pioglitazone	162,174	adiponectin	16,27	pioglitazone	adiponectin	MESH:C060836	9370	Chemical	Gene	treatment|nmod|START_ENTITY relation|nmod|treatment Polymorphism|dep|relation Polymorphism|nmod|END_ENTITY	Polymorphism of adiponectin -LRB- 45T/G -RRB- _ and_adiponectin_receptor-2 -LRB- 795G/A -RRB- in an Iranian population : relation with insulin resistance and response to treatment with pioglitazone in patients with type_2_diabetes_mellitus .
23142017	0	pioglitazone	27,39	adiponectin	72,83	pioglitazone	adiponectin	MESH:C060836	9370	Chemical	Gene	treatment|nmod|START_ENTITY reduces|nsubj|treatment reduces|xcomp|circulating circulating|dobj|END_ENTITY	Three-month treatment with pioglitazone reduces circulating C1q-binding adiponectin complex to total-adiponectin ratio , without changes in body mass index , in people with type 2 diabetes .
24482963	0	pioglitazone	97,109	adiponectin	14,25	pioglitazone	adiponectin	MESH:C060836	9370	Chemical	Gene	effects|nmod|START_ENTITY Regulation|dep|effects Regulation|nmod|secretion secretion|compound|END_ENTITY	Regulation of adiponectin secretion in human subcutaneous and omental adipose tissue : effects of pioglitazone and endothelin-1 : a pilot study .
24705615	0	pioglitazone	61,73	adiponectin	9,20	pioglitazone	adiponectin	MESH:C060836	9370	Chemical	Gene	response|acl|START_ENTITY influence|dobj|response influence|nsubj|levels levels|compound|END_ENTITY	Baseline adiponectin levels do not influence the response to pioglitazone in ACT NOW .
15585550	0	pioglitazone	10,22	adrenocorticotropic_hormone	26,53	pioglitazone	adrenocorticotropic hormone	MESH:C060836	5443	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|amod|END_ENTITY	Effect of pioglitazone on adrenocorticotropic_hormone and cortisol secretion in Cushing 's _ disease .
19371350	0	pioglitazone	63,75	dipeptidyl_peptidase-4	12,34	pioglitazone	dipeptidyl peptidase-4	MESH:C060836	13482(Tax:10090)	Chemical	Gene	inhibitor|nmod|START_ENTITY inhibitor|amod|END_ENTITY	Combining a dipeptidyl_peptidase-4 inhibitor , alogliptin , with pioglitazone improves glycaemic control , lipid profiles and beta-cell function in db/db mice .
18702951	0	pioglitazone	11,23	fetuin-A	33,41	pioglitazone	fetuin-A	MESH:C060836	197	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|amod|END_ENTITY	Effects of pioglitazone on serum fetuin-A levels in patients with type_2_diabetes_mellitus .
24551137	0	pioglitazone	29,41	fetuin-A	53,61	pioglitazone	fetuin-A	MESH:C060836	197	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|amod|END_ENTITY	Direct inhibitory effects of pioglitazone on hepatic fetuin-A expression .
24867508	0	pioglitazone	10,22	hypoxia-inducible_factor_1a	40,67	pioglitazone	hypoxia-inducible factor 1a	MESH:C060836	29560(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	Effect of pioglitazone on expression of hypoxia-inducible_factor_1a and vascular_endothelial_growth_factor in ischemic hindlimb of diabetic rats .
11874940	0	pioglitazone	24,36	insulin	40,47	pioglitazone	insulin	MESH:C060836	3630	Chemical	Gene	START_ENTITY|nmod|sensitivity sensitivity|compound|END_ENTITY	Dose-response effect of pioglitazone on insulin sensitivity and insulin secretion in type 2 diabetes .
12773448	0	pioglitazone	21,33	insulin	37,44	pioglitazone	insulin	MESH:C060836	3630	Chemical	Gene	START_ENTITY|nmod|abnormalities abnormalities|compound|END_ENTITY	Selective effects of pioglitazone on insulin and androgen abnormalities in normo - and hyperinsulinaemic obese patients with polycystic_ovary_syndrome .
15270789	0	pioglitazone	21,33	insulin	55,62	pioglitazone	insulin	MESH:C060836	3630	Chemical	Gene	vs.|amod|START_ENTITY effects|nmod|vs. glibenclamide|nsubj|effects glibenclamide|nmod|sensitivity sensitivity|compound|END_ENTITY	Sustained effects of pioglitazone vs. glibenclamide on insulin sensitivity , glycaemic control , and lipid profiles in patients with Type 2 diabetes .
15292314	0	pioglitazone	33,45	insulin	14,21	pioglitazone	insulin	MESH:C060836	3630	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|sensitizer sensitizer|compound|END_ENTITY	Effect of the insulin sensitizer pioglitazone on insulin resistance , hyperandrogenism , and ovulatory_dysfunction in women with polycystic_ovary_syndrome .
15292314	0	pioglitazone	33,45	insulin	49,56	pioglitazone	insulin	MESH:C060836	3630	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	Effect of the insulin sensitizer pioglitazone on insulin resistance , hyperandrogenism , and ovulatory_dysfunction in women with polycystic_ovary_syndrome .
15624096	0	pioglitazone	94,106	insulin	9,16	pioglitazone	insulin	MESH:C060836	3630	Chemical	Gene	dysregulation|nmod|START_ENTITY dysregulation|nsubj|sensitivity sensitivity|compound|END_ENTITY	Improved insulin sensitivity and adipose tissue dysregulation after short-term treatment with pioglitazone in non-diabetic , insulin-resistant subjects .
15644405	0	pioglitazone	152,164	insulin	125,132	pioglitazone	insulin	MESH:C060836	3630	Chemical	Gene	treatment|amod|START_ENTITY sensitivity|nmod|treatment sensitivity|compound|END_ENTITY	Luteinizing hormone secretion is not influenced by insulin infusion in women with polycystic_ovary_syndrome despite improved insulin sensitivity during pioglitazone treatment .
15644405	0	pioglitazone	152,164	insulin	51,58	pioglitazone	insulin	MESH:C060836	3630	Chemical	Gene	treatment|amod|START_ENTITY sensitivity|nmod|treatment influenced|nmod|sensitivity influenced|nmod|infusion infusion|compound|END_ENTITY	Luteinizing hormone secretion is not influenced by insulin infusion in women with polycystic_ovary_syndrome despite improved insulin sensitivity during pioglitazone treatment .
15978304	0	pioglitazone	21,33	insulin	152,159	pioglitazone	insulin	MESH:C060836	3630	Chemical	Gene	effects|nmod|START_ENTITY effects|acl:relcl|controlled controlled|nmod|therapy therapy|compound|END_ENTITY	Metabolic effects of pioglitazone in combination with insulin in patients with type_2_diabetes_mellitus whose disease is not adequately controlled with insulin therapy : results of a six-month , randomized , double-blind , prospective , multicenter , parallel-group study .
15978304	0	pioglitazone	21,33	insulin	54,61	pioglitazone	insulin	MESH:C060836	3630	Chemical	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	Metabolic effects of pioglitazone in combination with insulin in patients with type_2_diabetes_mellitus whose disease is not adequately controlled with insulin therapy : results of a six-month , randomized , double-blind , prospective , multicenter , parallel-group study .
16429317	0	pioglitazone	44,56	insulin	31,38	pioglitazone	insulin	MESH:C060836	3630	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of sensitisation to insulin with pioglitazone on fasting and postprandial lipid metabolism , lipoprotein modification by lipases , and lipid transfer activities in type 2 diabetic patients .
16508777	0	pioglitazone	23,35	insulin	132,139	pioglitazone	insulin	MESH:C060836	3630	Chemical	Gene	influence|nsubj|START_ENTITY influence|nmod|diabetes diabetes|acl|treated treated|nmod|END_ENTITY	The insulin sensitiser pioglitazone does not influence skin microcirculatory function in patients with type 2 diabetes treated with insulin .
16781793	0	pioglitazone	10,22	insulin	26,33	pioglitazone	insulin	MESH:C060836	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of pioglitazone on insulin secretion in patients with both impaired fasting glucose and impaired_glucose_tolerance .
17007957	0	pioglitazone	105,117	insulin	20,27	pioglitazone	insulin	MESH:C060836	3630	Chemical	Gene	Association|nmod|START_ENTITY Association|nmod|resistance resistance|compound|END_ENTITY	Association between insulin resistance and endothelial_dysfunction in type 2 diabetes and the effects of pioglitazone .
17084385	2	pioglitazone	268,280	insulin	312,319	pioglitazone	insulin	MESH:C060836	3630	Chemical	Gene	caused|nsubj|START_ENTITY caused|nmod|secretion secretion|compound|END_ENTITY	In 5 mM glucose , pioglitazone caused a transient increase in insulin secretion in non-diabetic , but not diabetic , islets .
17587394	0	pioglitazone	10,22	insulin	43,50	pioglitazone	insulin	MESH:C060836	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|therapy therapy|compound|END_ENTITY	Effect of pioglitazone in combination with insulin therapy on glycaemic control , insulin dose requirement and lipid profile in patients with type 2 diabetes previously poorly controlled with combination therapy .
17914032	0	pioglitazone	29,41	insulin	85,92	pioglitazone	insulin	MESH:C060836	3630	Chemical	Gene	effects|nmod|START_ENTITY Comparison|nmod|effects Comparison|nmod|action action|compound|END_ENTITY	Comparison of the effects of pioglitazone and metformin on hepatic and extra-hepatic insulin action in people with type 2 diabetes .
18544618	0	pioglitazone	145,157	insulin	9,16	pioglitazone	insulin	MESH:C060836	3630	Chemical	Gene	treatment|amod|START_ENTITY reversed|nmod|treatment reversed|nsubjpass|activation activation|compound|END_ENTITY	Impaired insulin activation and dephosphorylation of glycogen_synthase in skeletal muscle of women with polycystic_ovary_syndrome is reversed by pioglitazone treatment .
18769904	0	pioglitazone	11,23	insulin	54,61	pioglitazone	insulin	MESH:C060836	3630	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|resistance resistance|compound|END_ENTITY	Effects of pioglitazone and metformin on NEFA-induced insulin resistance in type 2 diabetes .
18793563	0	pioglitazone	41,53	insulin	76,83	pioglitazone	insulin	MESH:C060836	3630	Chemical	Gene	START_ENTITY|nmod|improvement improvement|nmod|resistance resistance|compound|END_ENTITY	Clinical investigation of the effects of pioglitazone on the improvement of insulin resistance and blood pressure in type 2-diabetic patients undergoing hemodialysis .
19217454	0	pioglitazone	177,189	insulin	32,39	pioglitazone	insulin	MESH:C060836	3630	Chemical	Gene	Relationship|dep|START_ENTITY Relationship|nmod|changes changes|nmod|sensitivity sensitivity|compound|END_ENTITY	Relationship between changes in insulin sensitivity and associated cardiovascular_disease risk factors in thiazolidinedione-treated , insulin-resistant , nondiabetic individuals : pioglitazone versus rosiglitazone .
19473593	0	pioglitazone	45,57	insulin	10,17	pioglitazone	insulin	MESH:C060836	3630	Chemical	Gene	treatment|nmod|START_ENTITY treatment|compound|END_ENTITY	Impact of insulin sensitivity treatment with pioglitazone on endothelial function in non-diabetic patients with arterial_hypertension .
19902036	0	pioglitazone	114,126	insulin	51,58	pioglitazone	insulin	MESH:C060836	3630	Chemical	Gene	therapy|amod|START_ENTITY weeks|nmod|therapy pressure|nmod|weeks pressure|nmod|resistance resistance|compound|END_ENTITY	Correlation between changes of blood pressure with insulin resistance in type_2_diabetes_mellitus with 4 weeks of pioglitazone therapy .
20144400	0	pioglitazone	9,21	insulin	92,99	pioglitazone	insulin	MESH:C060836	3630	Chemical	Gene	treatment|amod|START_ENTITY maintains|nmod|treatment maintains|dobj|effect effect|nmod|infusion infusion|compound|END_ENTITY	Combined pioglitazone and metformin treatment maintains the beneficial effect of short-term insulin infusion in patients with type 2 diabetes : results from a pilot study .
20237169	0	pioglitazone	64,76	insulin	37,44	pioglitazone	insulin	MESH:C060836	3630	Chemical	Gene	trial|amod|START_ENTITY END_ENTITY|nmod|trial	Pioglitazone use in combination with insulin in the prospective pioglitazone clinical trial in macrovascular events study -LRB- PROactive19 -RRB- .
20350924	0	pioglitazone	55,67	insulin	31,38	pioglitazone	insulin	MESH:C060836	3630	Chemical	Gene	glargine|nmod|START_ENTITY glargine|nsubj|control control|nmod|END_ENTITY	Improved glycemic control with insulin glargine versus pioglitazone as add-on therapy to sulfonylurea or metformin in patients with uncontrolled type_2_diabetes_mellitus .
20816593	0	pioglitazone	16,28	insulin	70,77	pioglitazone	insulin	MESH:C060836	3630	Chemical	Gene	addition|nmod|START_ENTITY controlled|nsubj|addition controlled|nmod|therapy therapy|compound|END_ENTITY	The addition of pioglitazone in type 2 diabetics poorly controlled on insulin therapy : a meta-analysis .
22187345	0	pioglitazone	162,174	insulin	112,119	pioglitazone	insulin	MESH:C060836	3630	Chemical	Gene	treatment|nmod|START_ENTITY relation|nmod|treatment relation|nmod|resistance resistance|compound|END_ENTITY	Polymorphism of adiponectin -LRB- 45T/G -RRB- _ and_adiponectin_receptor-2 -LRB- 795G/A -RRB- in an Iranian population : relation with insulin resistance and response to treatment with pioglitazone in patients with type_2_diabetes_mellitus .
22334369	0	pioglitazone	77,89	insulin	45,52	pioglitazone	insulin	MESH:C060836	3630	Chemical	Gene	treated|nmod|START_ENTITY resistance|acl|treated resistance|compound|END_ENTITY	Chronic hepatitis_C genotype 1 patients with insulin resistance treated with pioglitazone and peginterferon alpha-2a plus ribavirin .
22532269	0	pioglitazone	110,122	insulin	36,43	pioglitazone	insulin	MESH:C060836	3630	Chemical	Gene	Relationship|dep|START_ENTITY Relationship|nmod|resistance resistance|compound|END_ENTITY	Relationship between adipose tissue insulin resistance and liver histology in nonalcoholic_steatohepatitis : a pioglitazone versus vitamin_E versus placebo for the treatment of nondiabetic patients with nonalcoholic_steatohepatitis trial follow-up study .
24814528	0	pioglitazone	34,46	insulin	15,22	pioglitazone	insulin	MESH:C060836	3630	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|sensitizer sensitizer|compound|END_ENTITY	Effects of the insulin sensitizer pioglitazone on menstrual_irregularity , insulin resistance and hyperandrogenism in young women with polycystic_ovary_syndrome .
25134381	0	pioglitazone	38,50	insulin	54,61	pioglitazone	insulin	MESH:C060836	3630	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|resistance resistance|compound|END_ENTITY	The endothelial protective effects of pioglitazone on insulin resistance in endothelial cells .
26215435	0	pioglitazone	35,47	insulin	70,77	pioglitazone	insulin	MESH:C060836	3630	Chemical	Gene	START_ENTITY|acl:relcl|starting starting|dobj|END_ENTITY	Continuation or discontinuation of pioglitazone when starting bedtime insulin in patients with poorly controlled type 2 diabetes in an inner-city population .
26089929	0	pioglitazone	14,26	interleukin-10	42,56	pioglitazone	interleukin-10	MESH:C060836	3586	Chemical	Gene	START_ENTITY|acl|circulating circulating|dobj|levels levels|amod|END_ENTITY	The effect of pioglitazone on circulating interleukin-10 and tumor_necrosis_factor-alpha levels in a patient with metabolic_syndrome : A randomized , double-blind controlled trial .
16506273	0	pioglitazone	10,22	liver-type_fatty_acid-binding_protein	34,71	pioglitazone	liver-type fatty acid-binding protein	MESH:C060836	2168	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|concentrations concentrations|amod|END_ENTITY	Effect of pioglitazone on urinary liver-type_fatty_acid-binding_protein concentrations in diabetes patients with microalbuminuria .
19135426	0	pioglitazone	18,30	matrix_metalloproteinase-9	39,65	pioglitazone	matrix metalloproteinase-9	MESH:C060836	17395(Tax:10090)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|activity activity|amod|END_ENTITY	PPARgamma agonist pioglitazone reduces matrix_metalloproteinase-9 activity and neuronal_damage after focal cerebral_ischemia .
15265379	0	pioglitazone	11,23	matrix_metalloproteinases_2_and_9	42,75	pioglitazone	matrix metalloproteinases 2 and 9	MESH:C060836	81686(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expressions expressions|nmod|END_ENTITY	Effects of pioglitazone on expressions of matrix_metalloproteinases_2_and_9 in kidneys of diabetic rats .
20961967	0	pioglitazone	10,22	osteoprotegerin	50,65	pioglitazone	osteoprotegerin	MESH:C060836	4982	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|concentrations concentrations|nmod|END_ENTITY	Effect of pioglitazone on serum concentrations of osteoprotegerin in patients with type_2_diabetes_mellitus .
15001599	0	pioglitazone	73,85	peroxisomal_proliferator-activated_receptor-gamma	15,64	pioglitazone	peroxisomal proliferator-activated receptor-gamma	MESH:C060836	5468	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|agonist agonist|amod|END_ENTITY	Effects of the peroxisomal_proliferator-activated_receptor-gamma agonist pioglitazone on renal and hormonal responses to salt in healthy men .
20414637	0	pioglitazone	79,91	peroxisome_proliferator-activated_receptor	15,57	pioglitazone	peroxisome proliferator-activated receptor	MESH:C060836	5465	Chemical	Gene	Effects|dep|START_ENTITY Effects|nmod|END_ENTITY	Effects of the peroxisome_proliferator-activated_receptor -LRB- PPAR -RRB- - gamma agonist pioglitazone on renal and hormonal responses to salt in diabetic and hypertensive individuals .
12153485	0	pioglitazone	82,94	peroxisome_proliferator-activated_receptor-gamma	25,73	pioglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C060836	19016(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|action action|nmod|agonist agonist|amod|END_ENTITY	Protective action of the peroxisome_proliferator-activated_receptor-gamma agonist pioglitazone in a mouse model of Parkinson 's _ disease .
12688513	0	pioglitazone	125,137	peroxisome_proliferator-activated_receptor-gamma	68,116	pioglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C060836	25664(Tax:10116)	Chemical	Gene	ligand|advmod|START_ENTITY ligand|nsubj|Suppression Suppression|nmod|injury injury|nmod|END_ENTITY	Suppression of intestinal_ischemia-reperfusion injury by a specific peroxisome_proliferator-activated_receptor-gamma ligand , pioglitazone , in rats .
12688526	0	pioglitazone	81,93	peroxisome_proliferator-activated_receptor-gamma	11,59	pioglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C060836	25664(Tax:10116)	Chemical	Gene	ligand|advmod|START_ENTITY ligand|nsubj|END_ENTITY	A specific peroxisome_proliferator-activated_receptor-gamma -LRB- PPAR-gamma -RRB- ligand , pioglitazone , ameliorates gastric_mucosal_damage induced by ischemia and reperfusion in rats .
12805475	0	pioglitazone	118,130	peroxisome_proliferator-activated_receptor-gamma	68,116	pioglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C060836	25664(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Prevention Prevention|nmod|liver_injury liver_injury|nmod|rats rats|nmod|agonist agonist|nmod|END_ENTITY	Prevention of ethanol-induced liver_injury in rats by an agonist of peroxisome_proliferator-activated_receptor-gamma , pioglitazone .
15037267	0	pioglitazone	49,61	peroxisome_proliferator-activated_receptor-gamma	65,113	pioglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C060836	25664(Tax:10116)	Chemical	Gene	START_ENTITY|appos|ligand ligand|amod|END_ENTITY	Protective effects of preischemic treatment with pioglitazone , a peroxisome_proliferator-activated_receptor-gamma ligand , on lung_ischemia-reperfusion injury in rats .
15220243	0	pioglitazone	14,26	peroxisome_proliferator-activated_receptor-gamma	30,78	pioglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C060836	5468	Chemical	Gene	START_ENTITY|nmod|genes genes|amod|END_ENTITY	The effect of pioglitazone on peroxisome_proliferator-activated_receptor-gamma target genes related to lipid storage in vivo .
16051682	0	pioglitazone	128,140	peroxisome_proliferator-activated_receptor-gamma	71,119	pioglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C060836	5468	Chemical	Gene	START_ENTITY|nsubj|dynamics dynamics|nmod|cells cells|nmod|ligand ligand|amod|END_ENTITY	Growth dynamics of human leiomyoma cells and inhibitory effects of the peroxisome_proliferator-activated_receptor-gamma ligand , pioglitazone .
16085455	0	pioglitazone	62,74	peroxisome_proliferator-activated_receptor-gamma	4,52	pioglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C060836	25664(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	The peroxisome_proliferator-activated_receptor-gamma agonist , pioglitazone , inhibits fat accumulation and fibrosis in the livers of rats fed a choline-deficient , l-amino_acid-defined diet .
16687628	0	pioglitazone	157,169	peroxisome_proliferator-activated_receptor-gamma	46,94	pioglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C060836	5468	Chemical	Gene	effect|nmod|START_ENTITY mechanism|nmod|effect regulation|dep|mechanism regulation|nmod|gene gene|nmod|agonist agonist|amod|END_ENTITY	Transcriptional regulation of nephrin gene by peroxisome_proliferator-activated_receptor-gamma agonist : molecular mechanism of the antiproteinuric effect of pioglitazone .
18359318	0	pioglitazone	76,88	peroxisome_proliferator-activated_receptor-gamma	11,59	pioglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C060836	5468	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Effects of peroxisome_proliferator-activated_receptor-gamma activation with pioglitazone on plasma adipokines in nondiabetic patients with either hypercholesterolemia or hypertension .
20045142	0	pioglitazone	187,199	peroxisome_proliferator-activated_receptor-gamma	28,76	pioglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C060836	5468	Chemical	Gene	polymorphisms|acl|START_ENTITY polymorphisms|nmod|END_ENTITY	Common polymorphisms of the peroxisome_proliferator-activated_receptor-gamma -LRB- Pro12Ala -RRB- and peroxisome_proliferator-activated_receptor-gamma coactivator-1 -LRB- Gly482Ser -RRB- and the response to pioglitazone in Chinese patients with type_2_diabetes_mellitus .
20197197	0	pioglitazone	44,56	peroxisome_proliferator-activated_receptor-gamma	105,153	pioglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C060836	5468	Chemical	Gene	therapy|compound|START_ENTITY shifts|nmod|therapy shifts|dep|implications implications|nmod|use use|amod|END_ENTITY	Fluid compartmental shifts with efficacious pioglitazone therapy in overweight monkeys : implications for peroxisome_proliferator-activated_receptor-gamma agonist use in prediabetes .
17356310	0	pioglitazone	10,22	peroxisome_proliferator-activated_receptor_gamma	26,74	pioglitazone	peroxisome proliferator-activated receptor gamma	MESH:C060836	25664(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Effect of pioglitazone , a peroxisome_proliferator-activated_receptor_gamma agonist , on ischemia-reperfusion injury in rats .
17449904	0	pioglitazone	95,107	peroxisome_proliferator-activated_receptor_gamma	121,169	pioglitazone	peroxisome proliferator-activated receptor gamma	MESH:C060836	25664(Tax:10116)	Chemical	Gene	START_ENTITY|appos|ligand ligand|nmod|END_ENTITY	Suppression of N-nitrosobis -LRB- 2-oxopropyl -RRB- amine-induced pancreatic_carcinogenesis in hamsters by pioglitazone , a ligand of peroxisome_proliferator-activated_receptor_gamma .
19858066	0	pioglitazone	11,23	peroxisome_proliferator-activated_receptor_gamma	27,75	pioglitazone	peroxisome proliferator-activated receptor gamma	MESH:C060836	25664(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Effects of pioglitazone , a peroxisome_proliferator-activated_receptor_gamma agonist , on the urine and urothelium of the rat .
21339857	0	pioglitazone	68,80	peroxisome_proliferator-activated_receptor_gamma	10,58	pioglitazone	peroxisome proliferator-activated receptor gamma	MESH:C060836	5468	Chemical	Gene	agonist|dep|START_ENTITY agonist|nsubj|Effect Effect|nmod|END_ENTITY	Effect of peroxisome_proliferator-activated_receptor_gamma agonist -LRB- pioglitazone -RRB- and methotrexate on disease activity in rheumatoid_arthritis -LRB- experimental and clinical study -RRB- .
23313950	0	pioglitazone	128,140	peroxisome_proliferator-activated_receptor_gamma	71,119	pioglitazone	peroxisome proliferator-activated receptor gamma	MESH:C060836	5468	Chemical	Gene	START_ENTITY|nsubj|Suppression Suppression|nmod|hypertension hypertension|nmod|agonist agonist|amod|END_ENTITY	Suppression of primary_aldosteronism and resistant hypertension by the peroxisome_proliferator-activated_receptor_gamma agonist pioglitazone .
21968139	0	pioglitazone	169,181	peroxisome_proliferator-activated_receptor_y	16,60	pioglitazone	peroxisome proliferator-activated receptor y	MESH:C060836	5468	Chemical	Gene	treatment|nmod|START_ENTITY relation|nmod|treatment Polymorphism|dep|relation Polymorphism|nmod|Pro12Ala Pro12Ala|amod|END_ENTITY	Polymorphism of peroxisome_proliferator-activated_receptor_y -LRB- PPARy -RRB- Pro12Ala in the Iranian population : relation with insulin resistance and response to treatment with pioglitazone in type 2 diabetes .
26046374	0	pioglitazone	61,73	peroxisome_proliferator_activated_receptor_gamma	4,52	pioglitazone	peroxisome proliferator activated receptor gamma	MESH:C060836	5468	Chemical	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	The peroxisome_proliferator_activated_receptor_gamma agonist pioglitazone increases functional expression of the glutamate transporter excitatory amino_acid transporter 2 -LRB- EAAT2 -RRB- in human glioblastoma cells .
17046548	0	pioglitazone	106,118	plasminogen_activator_inhibitor_1	50,83	pioglitazone	plasminogen activator inhibitor 1	MESH:C060836	5054	Chemical	Gene	production|nmod|START_ENTITY production|nmod|END_ENTITY	Tumor_necrosis_factor-alpha-induced production of plasminogen_activator_inhibitor_1 and its regulation by pioglitazone and cerivastatin in a nonmalignant human hepatocyte cell line .
12201216	0	pioglitazone	10,22	proinsulin	32,42	pioglitazone	proinsulin	MESH:C060836	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|compound|END_ENTITY	Effect of pioglitazone on blood proinsulin levels in patients with type_2_diabetes_mellitus .
12821117	0	pioglitazone	118,130	proinsulin	53,63	pioglitazone	proinsulin	MESH:C060836	3630	Chemical	Gene	suppresses|nmod|START_ENTITY suppresses|dobj|biosynthesis biosynthesis|compound|END_ENTITY	PPAR-gamma overexpression suppresses glucose-induced proinsulin biosynthesis and insulin release synergistically with pioglitazone in MIN6 cells .
17327450	0	pioglitazone	11,23	suppressor_of_cytokine_signaling_3	27,61	pioglitazone	suppressor of cytokine signaling 3	MESH:C060836	12702(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effects of pioglitazone on suppressor_of_cytokine_signaling_3 expression : potential mechanisms for its effects on insulin sensitivity and adiponectin expression .
18778865	0	pioglitazone	15,27	visfatin	52,60	pioglitazone	visfatin	MESH:C060836	10135	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|levels levels|compound|END_ENTITY	The effects of pioglitazone and metformin on plasma visfatin levels in patients with treatment naive type_2_diabetes_mellitus .
19878073	0	pioglitazone	10,22	visfatin	26,34	pioglitazone	visfatin	MESH:C060836	297508(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of pioglitazone on visfatin expression in 3T3-L1 adipocytes and SD rats .
16978659	0	pipamperone	36,47	dopamine_D4_receptor	73,93	pipamperone	dopamine D4 receptor	MESH:C005569	1815	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Influence of the antipsychotic drug pipamperone on the expression of the dopamine_D4_receptor .
6248079	0	pipecurium_bromide	42,60	acetylcholinesterase	68,88	pipecurium bromide	acetylcholinesterase	MESH:D017300	43	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	The effect of the steroid muscle relaxant pipecurium_bromide on the acetylcholinesterase activity of red blood cells in vitro .
20041668	0	pipemidic_acid	18,32	autotaxin	33,42	pipemidic acid	autotaxin	MESH:D010876	5168	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	Optimization of a pipemidic_acid autotaxin inhibitor .
23286883	0	piperazine	30,40	CO2	13,16	piperazine	CO2	MESH:C034930	717	Chemical	Gene	solutions|compound|START_ENTITY END_ENTITY|nmod|solutions	Reactions of CO2 with aqueous piperazine solutions : formation and decomposition of mono - and dicarbamic_acids / carbamates of piperazine at 25.0 C. Piperazine -LRB- PZ -RRB- is widely recognized as a promising solvent for postcombustion capture -LRB- PCC -RRB- of carbon_dioxide -LRB- CO -LRB- 2 -RRB- -RRB- .
20137933	0	piperazine-bisamide	18,37	GHSR	38,42	piperazine-bisamide	GHSR	null	2693	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|compound|END_ENTITY	Identification of piperazine-bisamide GHSR antagonists for the treatment of obesity .
20605448	0	piperazine_hydroxamates	45,68	HDAC	100,104	piperazine hydroxamates	HDAC	null	9734	Chemical	Gene	activity|nmod|START_ENTITY activity|appos|END_ENTITY	Design , synthesis and anticancer activity of piperazine_hydroxamates and their histone_deacetylase -LRB- HDAC -RRB- inhibitory activity .
6466728	0	piperidine	25,35	albumin	65,72	piperidine	albumin	MESH:C032727	213	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	-LSB- Specific interaction of piperidine derivatives with human serum albumin -RSB- .
12565952	0	piperidine	16,26	p38	0,3	piperidine	p38	MESH:C032727	81649(Tax:10116)	Chemical	Gene	Inhibitors|amod|START_ENTITY Inhibitors|amod|END_ENTITY	p38 Inhibitors : piperidine - and 4-aminopiperidine-substituted_naphthyridinones , quinolinones , and dihydroquinazolinones .
16640339	0	piperidine-4-carboxamide	15,39	CCR5	40,44	piperidine-4-carboxamide	CCR5	null	1234	Chemical	Gene	antagonist|amod|START_ENTITY antagonist|compound|END_ENTITY	Discovery of a piperidine-4-carboxamide CCR5 antagonist -LRB- TAK-220 -RRB- with highly potent Anti-HIV-1 activity .
18662879	0	piperidine_carboxamide	13,35	TRPV1	36,41	piperidine carboxamide	TRPV1	CHEBI:48592	7442	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|compound|END_ENTITY	Discovery of piperidine_carboxamide TRPV1 antagonists .
25644934	0	piperidine_carboxamides	102,125	ALK	139,142	piperidine carboxamides	ALK	CHEBI:48592	238	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Importance of protein flexibility in ranking inhibitor affinities : modeling the binding mechanisms of piperidine_carboxamides as Type I1/2 ALK inhibitors .
25282655	0	piperidine_carboxamides	15,38	fatty_acid_amide_hydrolase	71,97	piperidine carboxamides	fatty acid amide hydrolase	CHEBI:48592	2166	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Piperazine and piperidine_carboxamides and carbamates as inhibitors of fatty_acid_amide_hydrolase -LRB- FAAH -RRB- and monoacylglycerol_lipase -LRB- MAGL -RRB- .
10074464	0	piperidines	32,43	Renin	0,5	piperidines	Renin	MESH:D010880	5972	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Renin inhibition by substituted piperidines : a novel paradigm for the inhibition of monomeric aspartic proteinases ?
21621998	0	piperidines	118,129	Renin	0,5	piperidines	Renin	MESH:D010880	403838(Tax:9615)	Chemical	Gene	series|nmod|START_ENTITY design|nmod|series inhibitors|dep|design inhibitors|compound|END_ENTITY	Renin inhibitors for the treatment of hypertension : design and optimization of a novel series of pyridone-substituted piperidines .
21641209	0	piperidines	122,133	Renin	0,5	piperidines	Renin	MESH:D010880	5972	Chemical	Gene	series|nmod|START_ENTITY design|nmod|series inhibitors|dep|design inhibitors|compound|END_ENTITY	Renin inhibitors for the treatment of hypertension : design and optimization of a novel series of tertiary alcohol-bearing piperidines .
25050166	0	piperidines	38,49	Renin	99,104	piperidines	Renin	MESH:D010880	5972	Chemical	Gene	START_ENTITY|nmod|class class|nmod|inhibitors inhibitors|amod|END_ENTITY	Structure-based design of substituted piperidines as a new class of highly efficacious oral direct Renin inhibitors .
10360744	0	piperidines	12,23	renin	39,44	piperidines	renin	MESH:D010880	5972	Chemical	Gene	START_ENTITY|dep|inhibitors inhibitors|compound|END_ENTITY	Substituted piperidines -- highly potent renin inhibitors due to induced fit adaptation of the active site .
21489792	0	piperidinyl_aminopyrimidine	13,40	IKK-2	56,61	piperidinyl aminopyrimidine	IKK-2	null	3551	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Discovery of piperidinyl_aminopyrimidine derivatives as IKK-2 inhibitors .
18480186	0	piperine	121,129	CYP3A4	156,162	piperine	CYP3A4	MESH:C008922	1576	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|compound|END_ENTITY	Curcuminoids inhibit multiple human cytochromes P450 , UDP-glucuronosyltransferase , and sulfotransferase enzymes , whereas piperine is a relatively selective CYP3A4 inhibitor .
15685214	0	piperine	11,19	TRPV1	93,98	piperine	TRPV1	MESH:C008922	7442	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|receptor receptor|appos|END_ENTITY	Effects of piperine , _ the_pungent_component_of_black_pepper , at the human vanilloid receptor -LRB- TRPV1 -RRB- .
17266134	0	piperine	106,114	TRPV1	0,5	piperine	TRPV1	MESH:C008922	83810(Tax:10116)	Chemical	Gene	study|nmod|START_ENTITY model|dep|study involved|nmod|model involved|nsubjpass|END_ENTITY	TRPV1 is involved in stretch-evoked contractile changes in the rat autonomous bladder model : a study with piperine , a new TRPV1 agonist .
17266134	0	piperine	106,114	TRPV1	122,127	piperine	TRPV1	MESH:C008922	83810(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	TRPV1 is involved in stretch-evoked contractile changes in the rat autonomous bladder model : a study with piperine , a new TRPV1 agonist .
20381363	0	piperine	27,35	TRPV1	9,14	piperine	TRPV1	MESH:C008922	7442	Chemical	Gene	activity|nmod|START_ENTITY derived|nsubj|activity derived|nmod|END_ENTITY	In vitro TRPV1 activity of piperine derived amides .
21703243	0	piperine	14,22	TRPV1	0,5	piperine	TRPV1	MESH:C008922	83810(Tax:10116)	Chemical	Gene	agonist|amod|START_ENTITY agonist|nummod|END_ENTITY	TRPV1 agonist piperine but not olvanil enhances glutamatergic spontaneous excitatory transmission in rat spinal substantia gelatinosa neurons .
25438036	0	piperine	11,19	TRPV1	28,33	piperine	TRPV1	MESH:C008922	7442	Chemical	Gene	START_ENTITY|nmod|ligands ligands|compound|END_ENTITY	Developing piperine towards TRPV1 and GABAA receptor ligands - synthesis of piperine analogs via Heck-coupling of conjugated dienes .
25438036	0	piperine	76,84	TRPV1	28,33	piperine	TRPV1	MESH:C008922	7442	Chemical	Gene	analogs|amod|START_ENTITY synthesis|nmod|analogs piperine|dep|synthesis piperine|nmod|ligands ligands|compound|END_ENTITY	Developing piperine towards TRPV1 and GABAA receptor ligands - synthesis of piperine analogs via Heck-coupling of conjugated dienes .
2783973	0	piperine	101,109	calcitonin_gene-related_peptide	15,46	piperine	calcitonin gene-related peptide	MESH:C008922	24241(Tax:10116)	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of calcitonin_gene-related_peptide in the positive chronotropic and inotropic effects of piperine and development of cross-tachyphylaxis between piperine and capsaicin in the isolated rat atria .
2783973	0	piperine	157,165	calcitonin_gene-related_peptide	15,46	piperine	calcitonin gene-related peptide	MESH:C008922	24241(Tax:10116)	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of calcitonin_gene-related_peptide in the positive chronotropic and inotropic effects of piperine and development of cross-tachyphylaxis between piperine and capsaicin in the isolated rat atria .
9457999	0	piperonyl_butoxide	28,46	CD-1	50,54	piperonyl butoxide	CD-1	MESH:D010882	111334(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|compound|END_ENTITY	Chronic_toxicity studies of piperonyl_butoxide in CD-1 mice : induction of hepatocellular_carcinoma .
4018535	0	piperonyl_butoxide	25,43	cytochrome_P-450	82,98	piperonyl butoxide	cytochrome P-450	MESH:D010882	13079(Tax:10090)	Chemical	Gene	interactions|nmod|START_ENTITY interactions|nmod|END_ENTITY	Spectral interactions of piperonyl_butoxide and isocyanides with purified hepatic cytochrome_P-450 from uninduced mice .
23122405	0	piperphentonamine	17,34	M1_and_M6	51,60	piperphentonamine	M1 and M6	MESH:C580809	100507027	Chemical	Gene	Determination|nmod|START_ENTITY END_ENTITY|nsubj|Determination	Determination of piperphentonamine and metabolites M1_and_M6 in human plasma and urine by LC/MS/MS and its application in a pharmacokinetics study in Chinese healthy volunteers .
24273275	0	piperphentonamine_hydrochloride	11,42	interleukin-1b	61,75	piperphentonamine hydrochloride	interleukin-1b	MESH:C580809	100135556(Tax:10141)	Chemical	Gene	START_ENTITY|nmod|expressions expressions|nmod|mRNA mRNA|amod|END_ENTITY	-LSB- Effect of piperphentonamine_hydrochloride on expressions of interleukin-1b and TNF-a mRNA and Fas protein in guinea_pigs with cochlear_ischemia / reperfusion injury -RSB- .
582756	0	piracetam	11,20	phospholipase_A2	50,66	piracetam	phospholipase A2	MESH:D010889	151056	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Effect of piracetam on neuronal and synaptosomal phospholipase_A2 activity -RSB- .
6628538	0	pirenperone	11,22	prolactin	45,54	pirenperone	prolactin	MESH:C034177	24683(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of pirenperone and ketanserin on rat prolactin secretion in vivo and in vitro .
1454656	0	pirenzepine	126,137	GH	31,33	pirenzepine	GH	MESH:D010890	2688	Chemical	Gene	-RSB-|amod|START_ENTITY system|nmod|-RSB- blockade|nmod|system GHRH|nmod|blockade response|xcomp|GHRH response|nsubj|Inhibition Inhibition|appos|END_ENTITY	-LSB- Inhibition of growth_hormone -LRB- GH -RRB- response to GHRH in diabetes_mellitus_type_1 after blockade of the cholinergic system with pirenzepine -RSB- .
1908328	0	pirenzepine	48,59	GH	77,79	pirenzepine	GH	MESH:D010890	2688	Chemical	Gene	secretion|amod|START_ENTITY secretion|compound|END_ENTITY	Blockade of cholinergic muscarinic receptors by pirenzepine and GHRH-induced GH secretion in the acute and recovery phase of anorexia_nervosa and atypical_eating_disorders .
9518881	0	pirenzepine	152,163	Growth_hormone	0,14	pirenzepine	Growth hormone	MESH:D010890	403795(Tax:9615)	Chemical	Gene	effect|nmod|START_ENTITY responses|dep|effect responses|amod|END_ENTITY	Growth_hormone responses to growth_hormone-releasing_hormone and hexarelin in fed and fasted dogs : effect of somatostatin infusion or pretreatment with pirenzepine .
2979673	0	pirenzepine	40,51	gastrin	104,111	pirenzepine	gastrin	MESH:D010890	2520	Chemical	Gene	Comparison|amod|START_ENTITY Comparison|appos|concentration concentration|compound|END_ENTITY	Comparison of two antimuscarinic drugs , pirenzepine and propantheline , on gastric acid secretion , serum gastrin concentration , salivary flow and heart rate in patients with duodenal_ulcer_disease .
6895273	0	pirenzepine	74,85	gastrin	26,33	pirenzepine	gastrin	MESH:D010890	2520	Chemical	Gene	-RSB-|amod|START_ENTITY Acid|nmod|-RSB- Acid|dobj|END_ENTITY	-LSB- Acid secretion and serum gastrin during acute and chronic treatment with pirenzepine in duodenal ulcer -LRB- author 's transl -RRB- -RSB- .
6895560	0	pirenzepine	35,46	gastrin	14,21	pirenzepine	gastrin	MESH:D010890	2520	Chemical	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Inhibition of gastrin secretion by pirenzepine -LRB- LS_519 -RRB- in treatment of gastric_ulcer .
8654146	0	pirenzepine	11,22	gastrin	45,52	pirenzepine	gastrin	MESH:D010890	25320(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of pirenzepine on omeprazole-induced gastrin gene expression in rat antral tissues .
1454656	0	pirenzepine	126,137	growth_hormone	15,29	pirenzepine	growth hormone	MESH:D010890	2688	Chemical	Gene	-RSB-|amod|START_ENTITY system|nmod|-RSB- blockade|nmod|system GHRH|nmod|blockade response|xcomp|GHRH response|nsubj|Inhibition Inhibition|nmod|END_ENTITY	-LSB- Inhibition of growth_hormone -LRB- GH -RRB- response to GHRH in diabetes_mellitus_type_1 after blockade of the cholinergic system with pirenzepine -RSB- .
2918051	0	pirenzepine	23,34	growth_hormone	45,59	pirenzepine	growth hormone	MESH:D010890	2688	Chemical	Gene	treatment|nmod|START_ENTITY decreases|nsubj|treatment decreases|dobj|secretion secretion|amod|END_ENTITY	Chronic treatment with pirenzepine decreases growth_hormone secretion in insulin-dependent_diabetes_mellitus .
3289300	0	pirenzepine	14,25	growth_hormone	29,43	pirenzepine	growth hormone	MESH:D010890	2688	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|levels levels|compound|END_ENTITY	The effect of pirenzepine on growth_hormone and blood glucose levels in type_I_diabetes_mellitus .
8176181	0	pirenzepine	90,101	growth_hormone	15,29	pirenzepine	growth hormone	MESH:D010890	2688	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	-LSB- Inhibition of growth_hormone in insulin-dependent diabetics after oral administration of pirenzepine .
8319519	0	pirenzepine	11,22	growth_hormone	68,82	pirenzepine	growth hormone	MESH:D010890	2688	Chemical	Gene	treatment|compound|START_ENTITY ineffective|nsubj|treatment ineffective|advcl|suppressing suppressing|dobj|secretion secretion|compound|END_ENTITY	Short term pirenzepine treatment is ineffective in suppressing 24-h growth_hormone secretion in type_1_diabetes_mellitus .
9518881	0	pirenzepine	152,163	growth_hormone-releasing_hormone	28,60	pirenzepine	growth hormone-releasing hormone	MESH:D010890	485863(Tax:9615)	Chemical	Gene	effect|nmod|START_ENTITY responses|dep|effect responses|nmod|END_ENTITY	Growth_hormone responses to growth_hormone-releasing_hormone and hexarelin in fed and fasted dogs : effect of somatostatin infusion or pretreatment with pirenzepine .
3886397	0	pirenzepine	11,22	insulin	33,40	pirenzepine	insulin	MESH:D010890	3630	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|compound|END_ENTITY	Effects of pirenzepine on plasma insulin , glucagon and pancreatic_polypeptide levels in normal man .
9075065	0	pirenzepine	35,46	insulin	50,57	pirenzepine	insulin	MESH:D010890	3630	Chemical	Gene	blockade|nmod|START_ENTITY Effects|nmod|blockade Effects|nmod|response response|compound|END_ENTITY	Effects of cholinergic blockade by pirenzepine on insulin and glucose response to oral and intravenous glucose and to arginine load in obesity .
6689490	0	pirenzepine	17,28	pancreatic_polypeptide	47,69	pirenzepine	pancreatic polypeptide	MESH:D010890	5539	Chemical	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	Possible role of pirenzepine on the release of pancreatic_polypeptide in duodenal ulcer patients : preliminary results of a randomized cross-over study .
9518881	0	pirenzepine	152,163	somatostatin	109,121	pirenzepine	somatostatin	MESH:D010890	403993(Tax:9615)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|infusion infusion|compound|END_ENTITY	Growth_hormone responses to growth_hormone-releasing_hormone and hexarelin in fed and fasted dogs : effect of somatostatin infusion or pretreatment with pirenzepine .
15571005	0	pirfenidone	28,39	TIMP-1	118,124	pirfenidone	TIMP-1	MESH:C093844	116510(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY mediated|nsubjpass|effect mediated|nmod|downregulation downregulation|nmod|alpha1 alpha1|amod|END_ENTITY	The anti-fibrotic effect of pirfenidone in rat liver fibrosis is mediated by downregulation of procollagen alpha1 -LRB- I -RRB- , TIMP-1 and MMP-2 .
10490926	0	pirfenidone	11,22	transforming_growth_factor-beta	26,57	pirfenidone	transforming growth factor-beta	MESH:C093844	7040	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|amod|END_ENTITY	Effects of pirfenidone on transforming_growth_factor-beta gene expression at the transcriptional level in bleomycin hamster model of lung_fibrosis .
12098600	0	pirfenidone	28,39	tumor_necrosis_factor-alpha	51,78	pirfenidone	tumor necrosis factor-alpha	MESH:C093844	21926(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	A novel anti-fibrotic agent pirfenidone suppresses tumor_necrosis_factor-alpha at the translational level .
578612	0	piribedil	10,19	prolactin	30,39	piribedil	prolactin	MESH:D010891	5617	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|compound|END_ENTITY	Effect of piribedil on plasma prolactin levels in women with puerperal or pathological hyperprolactinaemia .
562688	0	piridoxine	55,65	prolactin	32,41	piridoxine	prolactin	null	5617	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Suppression Suppression|nmod|END_ENTITY	Suppression of pimozide-induced prolactin secretion by piridoxine -LRB- vitamin_B6 -RRB- .
3431588	0	piritrexim	55,65	dihydrofolate_reductase	93,116	piritrexim	dihydrofolate reductase	MESH:C024530	609048(Tax:9615)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Preclinical biochemical pharmacology and toxicology of piritrexim , a lipophilic inhibitor of dihydrofolate_reductase .
9804692	0	piritrexim	62,72	dihydrofolate_reductase	90,113	piritrexim	dihydrofolate reductase	MESH:C024530	24312(Tax:10116)	Chemical	Gene	analogues|nmod|START_ENTITY -LSB-|dobj|analogues -LSB-|nmod|inhibitors inhibitors|nmod|END_ENTITY	6-Substituted_2 ,4 - diaminopyrido -LSB- 3,2-d -RSB- pyrimidine analogues of piritrexim as inhibitors of dihydrofolate_reductase from rat liver , Pneumocystis_carinii , and Toxoplasma_gondii and as antitumor agents .
12781338	0	pirlindole	102,112	Monoamine_oxidase_A	0,19	pirlindole	Monoamine oxidase A	MESH:C009830	4128	Chemical	Gene	structure|amod|START_ENTITY aspects|nmod|structure influenced|nmod|aspects influenced|nsubjpass|potency potency|compound|END_ENTITY	Monoamine_oxidase_A inhibitory potency and flavin perturbation are influenced by different aspects of pirlindole inhibitor structure .
9020990	0	pirlindole	81,91	monoamine_oxidase_A	106,125	pirlindole	monoamine oxidase A	MESH:C009830	4128	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	A double-blind randomized placebo-controlled study of the efficacy and safety of pirlindole , a reversible monoamine_oxidase_A inhibitor , in the treatment of depression .
9272198	0	pirlindole	124,134	monoamine_oxidase_A	92,111	pirlindole	monoamine oxidase A	MESH:C009830	4128	Chemical	Gene	study|amod|START_ENTITY study|nmod|efficacy efficacy|nmod|inhibitors inhibitors|compound|END_ENTITY	Double-blind randomized controlled study of the efficacy and tolerability of two reversible monoamine_oxidase_A inhibitors , pirlindole and moclobemide , in the treatment of depression .
7689093	0	piroxantrone	27,39	granulocyte_colony-stimulating_factor	45,82	piroxantrone	granulocyte colony-stimulating factor	MESH:C046659	1440	Chemical	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	Phase I study of high-dose piroxantrone with granulocyte_colony-stimulating_factor .
15573686	0	piroxicam	10,19	matrix_metalloproteinase_2	23,49	piroxicam	matrix metalloproteinase 2	MESH:D010894	17390(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of piroxicam on matrix_metalloproteinase_2 and apoptosis .
17226041	0	piscine_hemoflagellate	59,81	S-adenosylmethionine_synthetase	2,33	piscine hemoflagellate	S-adenosylmethionine synthetase	null	13385778	Chemical	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	A S-adenosylmethionine_synthetase gene from the pathogenic piscine_hemoflagellate , Cryptobia salmositica .
12048134	0	pitavastatin	25,37	HMG-CoA_reductase	54,71	pitavastatin	HMG-CoA reductase	MESH:C108475	3156	Chemical	Gene	treatment|nmod|START_ENTITY treatment|appos|inhibitor inhibitor|amod|END_ENTITY	Long-term treatment with pitavastatin -LRB- NK-104 -RRB- , a new HMG-CoA_reductase inhibitor , of patients with heterozygous familial_hypercholesterolemia .
12519692	0	pitavastatin	18,30	HMG-CoA_reductase	51,68	pitavastatin	HMG-CoA reductase	MESH:C108475	3156	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Metabolic fate of pitavastatin , a new inhibitor of HMG-CoA_reductase : human UDP-glucuronosyltransferase enzymes involved in lactonization .
12893526	0	pitavastatin	119,131	HMG-CoA_reductase	51,68	pitavastatin	HMG-CoA reductase	MESH:C108475	3156	Chemical	Gene	metabolism|nmod|START_ENTITY similarities|nmod|metabolism fate|dep|similarities fate|nmod|pitavastatin pitavastatin|appos|inhibitor inhibitor|nmod|END_ENTITY	Metabolic fate of pitavastatin , a new inhibitor of HMG-CoA_reductase : similarities and difference in the metabolism of pitavastatin in monkeys and humans .
12893526	0	pitavastatin	18,30	HMG-CoA_reductase	51,68	pitavastatin	HMG-CoA reductase	MESH:C108475	3156	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Metabolic fate of pitavastatin , a new inhibitor of HMG-CoA_reductase : similarities and difference in the metabolism of pitavastatin in monkeys and humans .
14969717	0	pitavastatin	61,73	HMG-CoA_reductase	32,49	pitavastatin	HMG-CoA reductase	MESH:C108475	25675(Tax:10116)	Chemical	Gene	effect|acl|START_ENTITY effect|nmod|inhibitor inhibitor|amod|END_ENTITY	Anti-lipid deposition effect of HMG-CoA_reductase inhibitor , pitavastatin , in a rat model of hypertension and hypercholesterolemia .
15618696	0	pitavastatin	18,30	HMG-CoA_reductase	51,68	pitavastatin	HMG-CoA reductase	MESH:C108475	15357(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Metabolic fate of pitavastatin , a new inhibitor of HMG-CoA_reductase -- effect of cMOAT deficiency_on_hepatobiliary_excretion in rats and of mdr1a/b gene disruption on tissue distribution in mice .
15618742	0	pitavastatin	20,32	HMG-CoA_reductase	53,70	pitavastatin	HMG-CoA reductase	MESH:C108475	25675(Tax:10116)	Chemical	Gene	mechanism|nmod|START_ENTITY mechanism|appos|inhibitor inhibitor|nmod|END_ENTITY	Uptake mechanism of pitavastatin , a new inhibitor of HMG-CoA_reductase , in rat hepatocytes .
16308507	0	pitavastatin	48,60	HMG-CoA_reductase	19,36	pitavastatin	HMG-CoA reductase	MESH:C108475	3156	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Biphasic effect of HMG-CoA_reductase inhibitor , pitavastatin , on vascular endothelial cells and angiogenesis .
21233289	0	pitavastatin	44,56	HMG-CoA_reductase	60,77	pitavastatin	HMG-CoA reductase	MESH:C108475	15357(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Inhibition of intestinal polyp formation by pitavastatin , a HMG-CoA_reductase inhibitor .
25894080	0	pitavastatin	21,33	HMG-CoA_reductase	38,55	pitavastatin	HMG-CoA reductase	MESH:C108475	3156	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Preconditioning with pitavastatin , an HMG-CoA_reductase inhibitor , attenuates C-Jun N-terminal kinase activation in experimental subarachnoid_hemorrhage-induced apoptosis .
24870014	0	pitavastatin	11,23	VCAM-1	45,51	pitavastatin	VCAM-1	MESH:C108475	7412	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effects of pitavastatin on the expression of VCAM-1 and its target gene miR-126 in cultured human umbilical vein endothelial cells .
17920663	0	pitavastatin	79,91	adiponectin	20,31	pitavastatin	adiponectin	MESH:C108475	9370	Chemical	Gene	treatment|compound|START_ENTITY Correlation|nmod|treatment Correlation|nmod|END_ENTITY	Correlation between adiponectin and reduction of cell adhesion molecules after pitavastatin treatment in hyperlipidemic patients with type_2_diabetes_mellitus .
18332608	0	pitavastatin	11,23	adiponectin	27,38	pitavastatin	adiponectin	MESH:C108475	9370	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of pitavastatin on adiponectin in patients with hyperlipidemia .
15474503	0	pitavastatin	10,22	apolipoprotein_A-I	26,44	pitavastatin	apolipoprotein A-I	MESH:C108475	335	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|production production|compound|END_ENTITY	Effect of pitavastatin on apolipoprotein_A-I production in HepG2 cell .
25062713	0	pitavastatin	141,153	apolipoprotein_A-I	16,34	pitavastatin	apolipoprotein A-I	MESH:C108475	335	Chemical	Gene	study|nmod|START_ENTITY Contribution|dep|study Contribution|acl|END_ENTITY	Contribution of apolipoprotein_A-I to the reduction in high-sensitivity C-reactive_protein levels by different statins : comparative study of pitavastatin and atorvastatin .
15701058	0	pitavastatin	21,33	interleukin-8	77,90	pitavastatin	interleukin-8	MESH:C108475	3576	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|production production|amod|END_ENTITY	Inhibitory effect of pitavastatin -LRB- NK-104 -RRB- on the C-reactive-protein-induced interleukin-8 production in human aortic endothelial cells .
16534182	0	pitavastatin	10,22	liver-type_fatty-acid-binding_protein	34,71	pitavastatin	liver-type fatty-acid-binding protein	MESH:C108475	2168	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of pitavastatin on urinary liver-type_fatty-acid-binding_protein in patients with nondiabetic mild chronic_kidney_disease .
16249547	0	pitavastatin	10,22	liver-type_fatty_acid-binding_protein	34,71	pitavastatin	liver-type fatty acid-binding protein	MESH:C108475	2168	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|amod|END_ENTITY	Effect of pitavastatin on urinary liver-type_fatty_acid-binding_protein levels in patients with early diabetic_nephropathy .
24870014	0	pitavastatin	11,23	miR-126	72,79	pitavastatin	miR-126	MESH:C108475	406913	Chemical	Gene	Effects|nmod|START_ENTITY Effects|amod|END_ENTITY	Effects of pitavastatin on the expression of VCAM-1 and its target gene miR-126 in cultured human umbilical vein endothelial cells .
19525846	0	pitavastatin	11,23	monocyte_chemoattractant_protein-1	27,61	pitavastatin	monocyte chemoattractant protein-1	MESH:C108475	6347	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of pitavastatin on monocyte_chemoattractant_protein-1 in hyperlipidemic patients .
22807641	0	pitavastatin	11,23	plasminogen_activator_inhibitor-1	27,60	pitavastatin	plasminogen activator inhibitor-1	MESH:C108475	5054	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of pitavastatin on plasminogen_activator_inhibitor-1 in hyperlipidemic patients .
24466319	0	pizotifen	47,56	5-HT2A_receptor	19,34	pizotifen	5-HT2A receptor	MESH:D010918	15558(Tax:10090)	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|amod|END_ENTITY	The antidepressant 5-HT2A_receptor antagonists pizotifen and cyproheptadine inhibit serotonin-enhanced platelet function .
8639487	0	plastocyanin	40,52	cytochrome_c	75,87	plastocyanin	cytochrome c	null	54205	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Enforced interaction of one molecule of plastocyanin with two molecules of cytochrome_c and an electron-transfer reaction involving the hydrophobic patch on the plastocyanin surface .
23585472	0	platinum	16,24	ATP11B	0,6	platinum	ATP11B	MESH:D010984	23200	Chemical	Gene	resistance|compound|START_ENTITY mediates|dobj|resistance mediates|nsubj|END_ENTITY	ATP11B mediates platinum resistance in ovarian_cancer .
24792335	0	platinum	46,54	CTR1	19,23	platinum	CTR1	MESH:D010984	1317	Chemical	Gene	concentration|compound|START_ENTITY END_ENTITY|dobj|concentration	Copper transporter CTR1 expression and tissue platinum concentration in non-small_cell_lung_cancer .
22435971	0	platinum	52,60	Calpain-2	0,9	platinum	Calpain-2	MESH:D010984	824	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|expression expression|amod|END_ENTITY	Calpain-2 expression is associated with response to platinum based chemotherapy , progression-free and overall survival in ovarian_cancer .
19330779	0	platinum	2,10	POLB	34,38	platinum	POLB	MESH:D010984	5423	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A platinum agent resistance gene , POLB , is a prognostic indicator in colorectal_cancer .
23982437	0	platinum	87,95	RRM1	30,34	platinum	RRM1	MESH:D010984	6240	Chemical	Gene	polymorphisms|nmod|START_ENTITY polymorphisms|nummod|END_ENTITY	Predictive value of ERCC1 and RRM1 gene single-nucleotide polymorphisms for first-line platinum - and gemcitabine-based chemotherapy in non-small_cell_lung_cancer patients .
22331725	0	platinum	68,76	TP53	0,4	platinum	TP53	MESH:D010984	7157	Chemical	Gene	status|nmod|START_ENTITY status|compound|END_ENTITY	TP53 gene status and human papilloma_virus_infection in response to platinum plus taxane-based chemotherapy of epithelial ovarian_carcinomas .
9891541	0	platinum	89,97	p53	0,3	platinum	p53	MESH:D010984	7157	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|expression expression|compound|END_ENTITY	p53 and bcl-2 expression in locally advanced squamous cell_head-neck_cancer treated with platinum based chemotherapy and radiotherapy .
21909579	0	platinum	21,29	phospholipase_A2	86,102	platinum	phospholipase A2	MESH:D010984	151056	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Inhibitory effect of platinum and ruthenium_bipyridyl_complexes on porcine pancreatic phospholipase_A2 .
23062942	0	platinum	52,60	snail	88,93	platinum	snail	MESH:D010984	6615	Chemical	Gene	Determination|nmod|START_ENTITY Determination|nmod|END_ENTITY	Determination of oral uptake and biodistribution of platinum and chromium by the garden snail -LRB- Helix aspersa -RRB- employing nano-secondary ion mass-spectrometry .
24679318	0	platinum	45,53	spin	25,29	platinum	spin	MESH:D010984	10927	Chemical	Gene	effect|nmod|START_ENTITY effect|compound|END_ENTITY	Spin pumping and inverse spin Hall effect in platinum : the essential role of spin-memory_loss at metallic interfaces .
24753635	0	platinum	80,88	spin	41,45	platinum	spin	MESH:D010984	10927	Chemical	Gene	bilayers|nsubj|START_ENTITY Influence|parataxis|bilayers Influence|acl|damping damping|dobj|MnO3 MnO3|amod|constant constant|nmod|voltage voltage|compound|END_ENTITY	Influence of damping constant on inverse spin hall voltage of La0 .7 Sr0 .3 MnO3 -LRB- x -RRB- / platinum bilayers .
212121	0	platinum	11,19	transferrin	29,40	platinum	transferrin	MESH:D010984	7018	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of platinum to human transferrin .
11153586	0	platinum_salt	81,94	T-cell_receptor	0,15	platinum salt	T-cell receptor	null	6962	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	T-cell_receptor repertoire expression in workers with occupational_asthma due to platinum_salt .
2471968	0	plaunotol	10,19	secretin	41,49	plaunotol	secretin	MESH:C047686	6343	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of plaunotol on release of plasma secretin and pancreatic exocrine secretion in humans .
24739265	0	plumbagin	66,75	CRM1	0,4	plumbagin	CRM1	MESH:C014758	7514	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	CRM1 is a direct cellular target of the natural anti-cancer agent plumbagin .
15638999	0	plumbagin	32,41	Nox-4	14,19	plumbagin	Nox-4	MESH:C014758	50507	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Inhibition of Nox-4 activity by plumbagin , a plant-derived bioactive naphthoquinone .
24489986	0	plumbagin	39,48	Nox4	22,26	plumbagin	Nox4	MESH:C014758	50507	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Inhibition of nuclear Nox4 activity by plumbagin : effect on proliferative capacity in human amniotic stem cells .
24134008	0	plumbagin	12,21	TNF-alpha	39,48	plumbagin	TNF-alpha	MESH:C014758	7124	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of plumbagin on expression of TNF-alpha and PDGF-BB in human hepatic stellate cells activated by leptin -RSB- .
2973991	0	plumbagin	43,52	ecdysone_20-monooxygenase	101,126	plumbagin	ecdysone 20-monooxygenase	MESH:C014758	39592(Tax:7227)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|amod|END_ENTITY	Effects of the chitin synthetase inhibitor plumbagin and its 2-demethyl derivative juglone on insect ecdysone_20-monooxygenase activity .
25834399	0	plumbagin	90,99	sirtuin1	41,49	plumbagin	sirtuin1	MESH:C014758	23411	Chemical	Gene	pathways|nmod|START_ENTITY pathways|amod|END_ENTITY	Induction of apoptosis and autophagy via sirtuin1 - and PI3K/Akt/mTOR-mediated pathways by plumbagin in human prostate_cancer cells .
19283769	0	pluronic_P85	40,52	P-glycoprotein	56,70	pluronic P85	P-glycoprotein	MESH:C422648	5243	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|amod|END_ENTITY	Investigation of the micellar effect of pluronic_P85 on P-glycoprotein inhibition : cell accumulation and equilibrium dialysis studies .
18563860	0	pmol	54,58	erythropoietin	81,95	pmol	erythropoietin	null	2056	Chemical	Gene	levels|amod|START_ENTITY levels|nmod|END_ENTITY	Low_LC-MS / MS detection of glycopeptides released from pmol levels of recombinant erythropoietin using nanoflow HPLC-chip electrospray ionization .
19956717	0	pneumolysin	84,95	Toll-like_receptors_2_and_4	8,35	pneumolysin	Toll-like receptors 2 and 4	MESH:C032290	24088;21898	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Role Role|nmod|END_ENTITY	Role of Toll-like_receptors_2_and_4 in pulmonary_inflammation and injury induced by pneumolysin in mice .
19562271	0	podocin	34,41	Lmx1b	53,58	podocin	Lmx1b	null	4010	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	The transcriptional regulation of podocin -LRB- NPHS2 -RRB- by Lmx1b and a promoter single nucleotide polymorphism .
19562271	0	podocin	34,41	NPHS2	43,48	podocin	NPHS2	null	7827	Chemical	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	The transcriptional regulation of podocin -LRB- NPHS2 -RRB- by Lmx1b and a promoter single nucleotide polymorphism .
2192011	0	podophyllin	104,115	interferon_alpha_2b	61,80	podophyllin	interferon alpha 2b	MESH:D011033	3440	Chemical	Gene	trial|nmod|START_ENTITY trial|nmod|END_ENTITY	A randomized trial of combination therapy with intralesional interferon_alpha_2b and podophyllin versus podophyllin alone for the therapy of anogenital warts .
9845403	0	polaprezinc	102,113	Insulin-like_growth_factor_I	0,28	polaprezinc	Insulin-like growth factor I	MESH:C061957	100008668(Tax:9986)	Chemical	Gene	derivative|amod|START_ENTITY using|dobj|derivative evidence|acl|using wound|nsubj|evidence plays|parataxis|wound plays|nsubj|END_ENTITY	Insulin-like_growth_factor_I plays a role in gastric wound healing : evidence using a zinc derivative , polaprezinc , and an in vitro rabbit wound repair model .
10423164	0	polaprezinc	10,21	insulin-like_growth_factor_I	141,169	polaprezinc	insulin-like growth factor I	MESH:C061957	3479	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|role role|nmod|END_ENTITY	Effect of polaprezinc -LRB- N - -LRB- 3-aminopropionyl -RRB- - L-histidinato_zinc -RRB- , a novel antiulcer agent containing zinc , on cellular proliferation : role of insulin-like_growth_factor_I .
19763655	0	policosanol	43,54	HMGCoA_reductase	14,30	policosanol	HMGCoA reductase	MESH:C080710	3156	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Regulation of HMGCoA_reductase activity by policosanol and octacosadienol , a new synthetic analogue of octacosanol .
24749391	0	poloxamine	52,62	bone_morphogenetic_protein-2	64,92	poloxamine	bone morphogenetic protein-2	null	29373(Tax:10116)	Chemical	Gene	system|compound|START_ENTITY system|amod|END_ENTITY	Bone regeneration induced by an in situ gel-forming poloxamine , bone_morphogenetic_protein-2 system .
17908979	0	poly-L-glutamate_camptothecin	17,46	CT-2106	48,55	poly-L-glutamate camptothecin	CT-2106	MESH:C525022	1007456(Tax:194439)	Chemical	Gene	trial|nmod|START_ENTITY trial|appos|END_ENTITY	Phase I trial of poly-L-glutamate_camptothecin -LRB- CT-2106 -RRB- administered weekly in patients with advanced solid malignancies .
16276887	0	poly-aromatic_hydrocarbons	75,101	GST	43,46	poly-aromatic hydrocarbons	GST	null	373156	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	-LSB- Identification , cloning and sequencing of GST gene of bacterium degrading poly-aromatic_hydrocarbons -RSB- .
26321373	0	polyIC	72,78	PKR	87,90	polyIC	PKR	MESH:D011070	5610	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|compound|END_ENTITY	Insulin treatment promotes tyrosine phosphorylation of PKR and inhibits polyIC induced PKR threonine phosphorylation .
26385519	7	polyIC	1130,1136	TLR3	1115,1119	polyIC	TLR3	MESH:D011070	142980(Tax:10090)	Chemical	Gene	treatment|amod|START_ENTITY END_ENTITY|nmod|treatment	Mechanistic studies revealed colocalization and interaction of S100A9 with TLR3 following polyIC treatment .
26423178	5	poly_IC	779,786	ISG60	813,818	poly IC	IFN-b	MESH:D011070	3456	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	In the present study , we demonstrated that poly_IC induces the expression of ISG60 , also named as IFIT3 , in U373MG cells .
17574359	0	polyacetylene_falcarindiol	4,30	COX-1	36,41	polyacetylene falcarindiol	COX-1	null	5742	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	The polyacetylene_falcarindiol with COX-1 activity isolated from Aegopodium podagraria L. Extracts of Aegopodium podagraria L. were screened in vitro for cyclooxygenase-1 -LRB- COX-1 -RRB- inhibitory activity .
2394215	0	polyacrylamide	57,71	6-phosphogluconate_dehydrogenase	12,44	polyacrylamide	6-phosphogluconate dehydrogenase	CHEBI:51135	5226	Chemical	Gene	isozymes|nmod|START_ENTITY isozymes|amod|END_ENTITY	Analysis of 6-phosphogluconate_dehydrogenase isozymes by polyacrylamide gel isoelectric focusing .
6654856	0	polyacrylamide	67,81	apolipoproteins_B100_and_B48	12,40	polyacrylamide	apolipoproteins B100 and B48	CHEBI:51135	338	Chemical	Gene	START_ENTITY|nsubj|Analysis Analysis|nmod|END_ENTITY	Analysis of apolipoproteins_B100_and_B48 by sodium_dodecyl_sulfate polyacrylamide gradient gel electrophoresis .
16320587	0	polyactin_A	29,40	GM-CSF	55,61	polyactin A	GM-CSF	MESH:C064233	1437	Chemical	Gene	START_ENTITY|acl|combined combined|nmod|END_ENTITY	-LSB- Tumor-suppression effect of polyactin_A combined with GM-CSF , TNF-alpha and IL-4 on cord blood mononuclear cells -RSB- .
2284949	0	polyactin_A	12,23	IL-2	36,40	polyactin A	IL-2	MESH:C064233	3558	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	-LSB- Effects of polyactin_A on in vitro IL-2 production and responsiveness of human lymphocytes -RSB- .
20554526	0	polyadenosine	15,28	Nab2	101,105	polyadenosine	Nab2	MESH:C069424	852755(Tax:4932)	Chemical	Gene	RNA-binding_protein_2|amod|START_ENTITY RNA-binding_protein_2|appos|END_ENTITY	Recognition of polyadenosine RNA by the zinc finger domain of nuclear_poly -LRB- A -RRB- _ RNA-binding_protein_2 -LRB- Nab2 -RRB- is required for correct mRNA 3 ' - end formation .
22484098	0	polyadenosine	58,71	Nab2	93,97	polyadenosine	Nab2	MESH:C069424	852755(Tax:4932)	Chemical	Gene	START_ENTITY|dobj|protein protein|appos|END_ENTITY	The long and the short of it : the role of the zinc finger polyadenosine RNA binding protein , Nab2 , in control of poly -LRB- A -RRB- tail length .
24071581	0	polyadenosine	50,63	Nab2	71,75	polyadenosine	Nab2	MESH:C069424	852755(Tax:4932)	Chemical	Gene	recognition|nmod|START_ENTITY basis|nmod|recognition RNA|nsubj|basis RNA|nmod|fingers fingers|amod|END_ENTITY	Structural basis for the molecular recognition of polyadenosine RNA by Nab2 Zn fingers .
19303045	0	polyadenosine	85,98	ZC3H14	29,35	polyadenosine	ZC3H14	MESH:C069424	79882	Chemical	Gene	protein|compound|START_ENTITY isoforms|nmod|protein generate|dobj|isoforms generate|nsubj|variants variants|nmod|gene gene|compound|END_ENTITY	Splice variants of the human ZC3H14 gene generate multiple isoforms of a zinc finger polyadenosine RNA binding protein .
24671764	0	polyadenosine	37,50	ZC3H14	72,78	polyadenosine	ZC3H14	MESH:C069424	79882	Chemical	Gene	START_ENTITY|dobj|protein protein|appos|END_ENTITY	A conserved role for the zinc finger polyadenosine RNA binding protein , ZC3H14 , in control of poly -LRB- A -RRB- tail length .
8896758	0	polyadenylic_acid	15,32	histone_H1	43,53	polyadenylic acid	histone H1	null	3005	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of polyadenylic_acid -LRB- 5 ' -RRB- with histone_H1 or protamine .
21204215	0	polyalanine	4,15	ARX	0,3	polyalanine	ARX	MESH:C019529	170302	Chemical	Gene	expansions|compound|START_ENTITY expansions|compound|END_ENTITY	ARX polyalanine expansions are highly implicated in familial cases of mental_retardation with infantile_epilepsy_and / or_hand_dystonia .
23246292	0	polyalanine	99,110	ARX	125,128	polyalanine	ARX	MESH:C019529	170302	Chemical	Gene	expansions|amod|START_ENTITY expansions|nmod|END_ENTITY	A regulatory path associated with X-linked_intellectual_disability and epilepsy links KDM5C to the polyalanine expansions in ARX .
25171319	0	polyalanine	67,78	Aristaless-Related_Homeobox	39,66	polyalanine	Aristaless-Related Homeobox	MESH:C019529	11878(Tax:10090)	Chemical	Gene	mutations|compound|START_ENTITY mutations|amod|END_ENTITY	Dysgenesis of enteroendocrine cells in Aristaless-Related_Homeobox polyalanine expansion mutations .
15533998	0	polyalanine	2,13	Arx	33,36	polyalanine	Arx	MESH:C019529	170302	Chemical	Gene	expansion|amod|START_ENTITY expansion|nmod|END_ENTITY	A polyalanine tract expansion in Arx forms intranuclear inclusions and results in increased cell death .
22108177	0	polyalanine	26,37	Arx	57,60	polyalanine	Arx	MESH:C019529	170302	Chemical	Gene	expansion|amod|START_ENTITY expansion|nmod|END_ENTITY	Differential effects of a polyalanine tract expansion in Arx on neural development and gene expression .
22736773	0	polyalanine	21,32	FOXE1	15,20	polyalanine	FOXE1	MESH:C019529	2304	Chemical	Gene	START_ENTITY|nsubj|Association Association|nmod|END_ENTITY	Association of FOXE1 polyalanine repeat region with papillary_thyroid_cancer .
18158309	0	polyalanine	62,73	FOXL2	88,93	polyalanine	FOXL2	MESH:C019529	668	Chemical	Gene	expansions|amod|START_ENTITY expansions|nmod|END_ENTITY	Differential_aggregation_and_functional_impairment induced by polyalanine expansions in FOXL2 , a transcription factor involved in cranio-facial and ovarian development .
12073020	0	polyalanine	15,26	HOXA13	54,60	polyalanine	HOXA13	MESH:C019529	3209	Chemical	Gene	expansion|compound|START_ENTITY expansion|nmod|gene gene|compound|END_ENTITY	A novel stable polyalanine -LSB- poly -LRB- A -RRB- -RSB- expansion in the HOXA13 gene associated with hand-foot-genital_syndrome : proper function of poly -LRB- A -RRB- - harbouring transcription factors depends on a critical repeat length ?
17935235	0	polyalanine	37,48	HOXA13	30,36	polyalanine	HOXA13	MESH:C019529	3209	Chemical	Gene	START_ENTITY|nsubj|characterization characterization|nmod|END_ENTITY	Molecular characterization of HOXA13 polyalanine expansion proteins in hand-foot-genital_syndrome .
23532960	0	polyalanine	27,38	HOXA13	20,26	polyalanine	HOXA13	MESH:C019529	3209	Chemical	Gene	expansions|compound|START_ENTITY expansions|compound|END_ENTITY	Analysis of de novo HOXA13 polyalanine expansions supports replication slippage without repair in their generation .
16222680	0	polyalanine	113,124	HOXD13	106,112	polyalanine	HOXD13	MESH:C019529	3239	Chemical	Gene	expansions|compound|START_ENTITY expansions|compound|END_ENTITY	A 72-year-old Danish puzzle resolved -- comparative analysis of phenotypes in families with different-sized HOXD13 polyalanine expansions .
22378146	0	polyalanine	6,17	NIPA1	0,5	polyalanine	NIPA1	MESH:C019529	123606	Chemical	Gene	expansions|compound|START_ENTITY expansions|compound|END_ENTITY	NIPA1 polyalanine repeat expansions are associated with amyotrophic_lateral_sclerosis .
19641605	0	polyalanine	87,98	PABPN1	113,119	polyalanine	PABPN1	MESH:C019529	8106	Chemical	Gene	expansions|amod|START_ENTITY expansions|nmod|END_ENTITY	Hsp70 chaperones and type I PRMTs are sequestered at intranuclear inclusions caused by polyalanine expansions in PABPN1 .
15888479	0	polyalanine	55,66	PHOX2B	37,43	polyalanine	PHOX2B	MESH:C019529	8929	Chemical	Gene	expansions|amod|START_ENTITY associated|dobj|expansions associated|nsubj|mechanisms mechanisms|nmod|END_ENTITY	Distinct pathogenetic mechanisms for PHOX2B associated polyalanine expansions and frameshift mutations in congenital_central_hypoventilation_syndrome .
16258163	0	polyalanine	23,34	PHOX2B	49,55	polyalanine	PHOX2B	MESH:C019529	8929	Chemical	Gene	expansions|amod|START_ENTITY expansions|nmod|END_ENTITY	Sensitive detection of polyalanine expansions in PHOX2B by polymerase chain reaction using bisulfite-converted DNA .
17045833	0	polyalanine	97,108	PHOX2B	60,66	polyalanine	PHOX2B	MESH:C019529	8929	Chemical	Gene	expansions|amod|START_ENTITY containing|dobj|expansions proteins|acl|containing proteins|nummod|END_ENTITY	Geldanamycin promotes nuclear localisation and clearance of PHOX2B misfolded proteins containing polyalanine expansions .
17300129	0	polyalanine	71,82	PHOX2B	59,65	polyalanine	PHOX2B	MESH:C019529	8929	Chemical	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	Unequal crossover recombination - population screening for PHOX2B gene polyalanine polymorphism using CE .
17928950	0	polyalanine	8,19	PHOX2B	33,39	polyalanine	PHOX2B	MESH:C019529	8929	Chemical	Gene	START_ENTITY|dobj|expansion expansion|nmod|END_ENTITY	De novo polyalanine expansion of PHOX2B in congenital_central_hypoventilation_syndrome : unequal sister chromatid exchange during paternal gametogenesis .
22437207	0	polyalanine	15,26	PHOX2B	49,55	polyalanine	PHOX2B	MESH:C019529	8929	Chemical	Gene	mutation|amod|START_ENTITY mutation|nmod|END_ENTITY	Inheritance of polyalanine expansion mutation of PHOX2B in congenital_central_hypoventilation_syndrome .
23103552	0	polyalanine	92,103	PHOX2B	48,54	polyalanine	PHOX2B	MESH:C019529	8929	Chemical	Gene	mutations|amod|START_ENTITY induced|nmod|mutations induced|nsubj|Transcriptional_dysregulation Transcriptional_dysregulation|nmod|mechanism mechanism|compound|END_ENTITY	Transcriptional_dysregulation and impairment of PHOX2B auto-regulatory mechanism induced by polyalanine expansion mutations associated with congenital_central_hypoventilation_syndrome .
26011159	0	polyalanine	88,99	PHOX2B	81,87	polyalanine	PHOX2B	MESH:C019529	8929	Chemical	Gene	mutation|amod|START_ENTITY mutation|compound|END_ENTITY	Treatment of neuroblastoma in congenital_central_hypoventilation_syndrome with a PHOX2B polyalanine repeat expansion mutation : New twist on a neurocristopathy_syndrome .
10767417	0	polyamide	80,89	DNA_gyrase	24,34	polyamide	DNA gyrase	CHEBI:61445	7153	Chemical	Gene	START_ENTITY|nsubj|inhibition inhibition|nmod|END_ENTITY	Selective inhibition of DNA_gyrase in vitro by a GC specific eight-ring hairpin polyamide at nanomolar concentration .
23755272	0	polyamine	77,86	Agp2	0,4	polyamine	Agp2	CHEBI:60143	852429(Tax:4932)	Chemical	Gene	transport|amod|START_ENTITY regulates|dobj|transport regulates|nsubj|END_ENTITY	Agp2 , a member of the yeast amino_acid permease family , positively regulates polyamine transport at the transcriptional level .
18703589	0	polyamine	23,32	AtPAO4	42,48	polyamine	AtPAO4	CHEBI:60143	842894(Tax:3702)	Chemical	Gene	oxidase|compound|START_ENTITY oxidase|appos|END_ENTITY	A putative peroxisomal polyamine oxidase , AtPAO4 , is involved in polyamine catabolism in Arabidopsis_thaliana .
23508577	0	polyamine	70,79	LSD1	120,124	polyamine	LSD1	CHEBI:60143	23028	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	The re-expression of the epigenetically silenced e-cadherin gene by a polyamine analogue lysine-specific_demethylase-1 -LRB- LSD1 -RRB- inhibitor in human acute_myeloid_leukemia cell lines .
18548481	0	polyamine	75,84	ODC	38,41	polyamine	ODC	CHEBI:60143	4953	Chemical	Gene	synthesis|amod|START_ENTITY Effects|nmod|synthesis Effects|nmod|END_ENTITY	Effects of antisense RNA targeting of ODC and AdoMetDC on the synthesis of polyamine synthesis and cell growth in prostate_cancer cells using a prostatic androgen-dependent promoter in adenovirus .
15716048	0	polyamine	53,62	Ornithine_decarboxylase	0,23	polyamine	Ornithine decarboxylase	CHEBI:60143	4953	Chemical	Gene	amino_acids|amod|START_ENTITY inhibited|nmod|amino_acids inhibited|nsubjpass|activity activity|amod|END_ENTITY	Ornithine_decarboxylase activity is inhibited by the polyamine precursor amino_acids at the protein stability level in Caco-2 cells .
1577163	0	polyamine	94,103	Ornithine_decarboxylase	0,23	polyamine	Ornithine decarboxylase	CHEBI:60143	4953	Chemical	Gene	unstable|xcomp|START_ENTITY unstable|nsubj|END_ENTITY	Ornithine_decarboxylase from Crithidia fasciculata is metabolically unstable and resistant to polyamine down-regulation .
2582110	0	polyamine	82,91	Ornithine_decarboxylase	0,23	polyamine	Ornithine decarboxylase	CHEBI:60143	4953	Chemical	Gene	metabolism|amod|START_ENTITY model|nmod|metabolism inhibition|dep|model inhibition|amod|END_ENTITY	Ornithine_decarboxylase inhibition and the malaria-infected red cell : a model for polyamine metabolism and growth .
9698071	0	polyamine	29,38	P-glycoprotein	65,79	polyamine	P-glycoprotein	CHEBI:60143	67078(Tax:10090)	Chemical	Gene	transporters|amod|START_ENTITY transporters|appos|END_ENTITY	A unique interaction between polyamine and multidrug resistance -LRB- P-glycoprotein -RRB- transporters in cultured Chinese_hamster_ovary cells transfected with mouse mdr-1 gene .
17868688	0	polyamine	143,152	Tp0655	122,128	polyamine	Tp0655	CHEBI:60143	2611153(Tax:243276)	Chemical	Gene	receptor|amod|START_ENTITY END_ENTITY|nmod|receptor	Structural and biochemical basis for polyamine binding to the Tp0655 lipoprotein of Treponema_pallidum : putative role for Tp0655 -LRB- TpPotD -RRB- as a polyamine receptor .
11120661	0	polyamine	54,63	arginase_I	19,29	polyamine	arginase I	CHEBI:60143	513608(Tax:9913)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Regulatory role of arginase_I and II in nitric_oxide , polyamine , and proline syntheses in endothelial cells .
1532663	0	polyamine	14,23	atrial_natriuretic_peptide	59,85	polyamine	atrial natriuretic peptide	CHEBI:60143	24602(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY Inhibition|nmod|synthesis impairs|nsubj|Inhibition impairs|dobj|secretion secretion|nmod|END_ENTITY	Inhibition of polyamine synthesis impairs the secretion of atrial_natriuretic_peptide .
17119451	0	polyamine	12,21	atrial_natriuretic_peptide	147,173	polyamine	atrial natriuretic peptide	CHEBI:60143	230899(Tax:10090)	Chemical	Gene	levels|amod|START_ENTITY Decrease|nmod|levels Decrease|acl|induced induced|nmod|END_ENTITY	Decrease of polyamine levels and enhancement of transglutaminase activity in selective reduction of B16-F10 melanoma cell proliferation induced by atrial_natriuretic_peptide .
23508577	0	polyamine	70,79	lysine-specific_demethylase-1	89,118	polyamine	lysine-specific demethylase-1	CHEBI:60143	23028	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	The re-expression of the epigenetically silenced e-cadherin gene by a polyamine analogue lysine-specific_demethylase-1 -LRB- LSD1 -RRB- inhibitor in human acute_myeloid_leukemia cell lines .
10216947	0	polyamine	77,86	ornithine_decarboxylase	28,51	polyamine	ornithine decarboxylase	CHEBI:60143	4953	Chemical	Gene	pathway|amod|START_ENTITY regulation|nmod|pathway regulation|nmod|enzymes enzymes|amod|END_ENTITY	Translational regulation of ornithine_decarboxylase and other enzymes of the polyamine pathway .
11683273	0	polyamine	97,106	ornithine_decarboxylase	36,59	polyamine	ornithine decarboxylase	CHEBI:60143	4953	Chemical	Gene	pool|amod|START_ENTITY alters|dobj|pool alters|nsubj|Over-expression Over-expression|nmod|cDNA cDNA|nmod|END_ENTITY	Over-expression of a cDNA for human ornithine_decarboxylase in transgenic rice plants alters the polyamine pool in a tissue-specific manner .
1513327	0	polyamine	105,114	ornithine_decarboxylase	8,31	polyamine	ornithine decarboxylase	CHEBI:60143	4953	Chemical	Gene	analogs|amod|START_ENTITY activity|nmod|analogs Role|nmod|activity Role|nmod|suppression suppression|amod|END_ENTITY	Role of ornithine_decarboxylase suppression and polyamine depletion in the antiproliferative activity of polyamine analogs .
17148758	0	polyamine	80,89	ornithine_decarboxylase	21,44	polyamine	ornithine decarboxylase	CHEBI:60143	18263(Tax:10090)	Chemical	Gene	deprivation|amod|START_ENTITY influence|nmod|deprivation dimorphism|dep|influence dimorphism|nmod|END_ENTITY	Sexual dimorphism of ornithine_decarboxylase in the mouse adrenal : influence of polyamine deprivation on catecholamine and corticoid levels .
1918176	0	polyamine	71,80	ornithine_decarboxylase	21,44	polyamine	ornithine decarboxylase	CHEBI:60143	4953	Chemical	Gene	toxicity|amod|START_ENTITY prevention|nmod|toxicity regulation|dep|prevention regulation|amod|END_ENTITY	A new perspective on ornithine_decarboxylase regulation : prevention of polyamine toxicity is the overriding theme .
19554423	0	polyamine	43,52	ornithine_decarboxylase	19,42	polyamine	ornithine decarboxylase	CHEBI:60143	24609(Tax:10116)	Chemical	Gene	system|amod|START_ENTITY Involvement|dep|system Involvement|nmod|END_ENTITY	Involvement of the ornithine_decarboxylase / polyamine system in precondition-induced cardioprotection through an interaction with PKC in rat hearts .
20332625	0	polyamine	46,55	ornithine_decarboxylase	22,45	polyamine	ornithine decarboxylase	CHEBI:60143	4953	Chemical	Gene	system|amod|START_ENTITY inhibits|nsubj|system Downregulation|parataxis|inhibits Downregulation|nmod|END_ENTITY	Downregulation of the ornithine_decarboxylase / polyamine system inhibits angiotensin-induced hypertrophy of cardiomyocytes through the NO/cGMP-dependent protein kinase type-I pathway .
2095365	0	polyamine	14,23	ornithine_decarboxylase	52,75	polyamine	ornithine decarboxylase	CHEBI:60143	4953	Chemical	Gene	pools|amod|START_ENTITY Management|nmod|pools Management|nmod|END_ENTITY	Management of polyamine pools and the regulation of ornithine_decarboxylase .
2110039	0	polyamine	47,56	ornithine_decarboxylase	23,46	polyamine	ornithine decarboxylase	CHEBI:60143	24609(Tax:10116)	Chemical	Gene	system|compound|START_ENTITY system|amod|END_ENTITY	Trophic control of the ornithine_decarboxylase / polyamine system in neonatal rat brain regions : lesions caused by 6-hydroxydopamine produce effects selective for cerebellum .
22579641	0	polyamine	46,55	ornithine_decarboxylase	98,121	polyamine	ornithine decarboxylase	CHEBI:60143	4953	Chemical	Gene	levels|amod|START_ENTITY increases|dobj|levels increases|advcl|activating activating|dobj|transcription transcription|nmod|1-acetyltransferase 1-acetyltransferase|amod|END_ENTITY	Chemically induced oxidative stress increases polyamine levels by activating the transcription of ornithine_decarboxylase and spermidine/spermine-N 1-acetyltransferase in human hepatoma HUH7 cells .
23457004	0	polyamine	19,28	ornithine_decarboxylase	136,159	polyamine	ornithine decarboxylase	CHEBI:60143	4953	Chemical	Gene	inhibitor|amod|START_ENTITY AMXT-1501|appos|inhibitor synergizes|nsubj|AMXT-1501 synergizes|advcl|inhibiting inhibiting|advcl|targeting targeting|dobj|transport transport|amod|END_ENTITY	AMXT-1501 , a novel polyamine transport inhibitor , synergizes with DFMO in inhibiting neuroblastoma cell proliferation by targeting both ornithine_decarboxylase and polyamine transport .
24464033	0	polyamine	52,61	ornithine_decarboxylase	28,51	polyamine	ornithine decarboxylase	CHEBI:60143	24609(Tax:10116)	Chemical	Gene	system|compound|START_ENTITY system|amod|END_ENTITY	Akt and Erk1/2 activate the ornithine_decarboxylase / polyamine system in cardioprotective ischemic preconditioning in rats : the role of mitochondrial permeability transition pores .
2495941	0	polyamine	92,101	ornithine_decarboxylase	44,67	polyamine	ornithine decarboxylase	CHEBI:60143	4953	Chemical	Gene	synthesis|amod|START_ENTITY inhibitors|nmod|synthesis caused|nmod|inhibitors caused|nsubj|Involvement Involvement|nmod|antizyme antizyme|nmod|stabilization stabilization|nmod|END_ENTITY	Involvement of antizyme in stabilization of ornithine_decarboxylase caused by inhibitors of polyamine synthesis .
26884982	0	polyamine	32,41	ornithine_decarboxylase	8,31	polyamine	ornithine decarboxylase	CHEBI:60143	24609(Tax:10116)	Chemical	Gene	pathway|amod|START_ENTITY Role|dep|pathway Role|nmod|END_ENTITY	Role of ornithine_decarboxylase / polyamine pathway in focal cerebral_ischemia-reperfusion_injury and its mechanism in rats .
3741487	0	polyamine	61,70	ornithine_decarboxylase	113,136	polyamine	ornithine decarboxylase	CHEBI:60143	4953	Chemical	Gene	biosynthesis|amod|START_ENTITY inhibitor|nmod|biosynthesis inhibitor|acl:relcl|inhibits inhibits|xcomp|END_ENTITY	Methylglyoxal_bis -LRB- butylamidinohydrazone -RRB- , a new inhibitor of polyamine biosynthesis that simultaneously inhibits ornithine_decarboxylase , adenosylmethionine decarboxylase and spermidine synthase .
7360002	0	polyamine	53,62	ornithine_decarboxylase	148,171	polyamine	ornithine decarboxylase	CHEBI:60143	4953	Chemical	Gene	biosynthesis|amod|START_ENTITY interference|nmod|biosynthesis growth|nmod|interference Inhibition|nmod|growth Inhibition|dep|effects effects|nmod|alpha-difluoromethylornithine alpha-difluoromethylornithine|appos|inhibitor inhibitor|nmod|END_ENTITY	Inhibition of EMT6 tumor growth by interference with polyamine biosynthesis ; effects of alpha-difluoromethylornithine , an irreversible inhibitor of ornithine_decarboxylase .
8905633	0	polyamine	82,91	ornithine_decarboxylase	14,37	polyamine	ornithine decarboxylase	CHEBI:60143	4953	Chemical	Gene	line|amod|START_ENTITY Regulation|nmod|line Regulation|nmod|END_ENTITY	Regulation of ornithine_decarboxylase and S-adenosylmethionine_decarboxylase in a polyamine auxotrophic cell line .
24253595	0	polyamine	65,74	p38	49,52	polyamine	p38	CHEBI:60143	81649(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	The mechanism by which MEK/ERK regulates JNK and p38 activity in polyamine depleted IEC-6 cells during apoptosis .
10646846	0	polyamine	87,96	sulfated_glycoprotein_2	140,163	polyamine	sulfated glycoprotein 2	CHEBI:60143	1191	Chemical	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Tumor progression is accompanied by significant changes in the levels of expression of polyamine metabolism regulatory genes and clusterin -LRB- sulfated_glycoprotein_2 -RRB- in human prostate_cancer specimens .
15840035	0	polyamines	72,82	Albumin	0,7	polyamines	Albumin	MESH:D011073	213	Chemical	Gene	stimulates|nmod|START_ENTITY stimulates|nsubj|END_ENTITY	Albumin stimulates cell growth , l-arginine transport , and metabolism to polyamines in human proximal tubular cells .
16445292	0	polyamines	81,91	CK2	47,50	polyamines	CK2	MESH:D011073	13000(Tax:10090)	Chemical	Gene	stimulated|nmod|START_ENTITY stimulated|nsubjpass|END_ENTITY	A novel protein kinase CK2 substrate indicates CK2 is not directly stimulated by polyamines in vivo .
15494691	0	polyamines	8,18	NF-kappaB	67,76	polyamines	NF-kappaB	MESH:D011073	4790	Chemical	Gene	Role|nmod|START_ENTITY END_ENTITY|nsubj|Role	Role of polyamines in the function of nuclear transcription factor NF-kappaB in breast_cancer cells .
26405039	5	polyamines	1143,1153	OCT3	1338,1342	polyamines	OCT1	MESH:D011073	6580	Chemical	Gene	interactions|nmod|START_ENTITY interactions|nmod|END_ENTITY	Thus , interactions of natural polyamines -LRB- putrescine , spermidine , spermine -RRB- and polyamine-like potent OCT1 blockers -LRB- 1,10-diaminodecane , decamethonium , bis-triethylaminodecane , and 1,10 _ bis-quinuclidinedecane -RRB- with wild-type OCT3 were weak , but were significantly potentiated in the mutant OCT3s .
7865637	0	polyamines	55,65	Ornithine_decarboxylase	0,23	polyamines	Ornithine decarboxylase	MESH:D011073	24609(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Ornithine_decarboxylase activity and concentrations of polyamines in embryos of diabetic rats .
1841519	0	polyamines	48,58	Polyamine_oxidase	0,17	polyamines	Polyamine oxidase	MESH:D011073	196743	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Polyamine_oxidase activity and concentration of polyamines in tissues and serum of hamsters with transplantational pigmented melanoma_IC-Sofia .
7895239	0	polyamines	8,18	angiotensin_II	46,60	polyamines	angiotensin II	MESH:D011073	24179(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY induced|nsubj|Role induced|nmod|END_ENTITY	Role of polyamines in hypertension induced by angiotensin_II .
19718454	0	polyamines	61,71	antizyme_inhibitor_2	14,34	polyamines	antizyme inhibitor 2	MESH:D011073	113451	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of antizyme_inhibitor_2 in mast cells and role of polyamines as selective regulators of serotonin secretion .
2765563	0	polyamines	43,53	deoxyhypusine_hydroxylase	14,39	polyamines	deoxyhypusine hydroxylase	MESH:D011073	100771021	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of deoxyhypusine_hydroxylase by polyamines and by a deoxyhypusine peptide .
1782416	0	polyamines	8,18	epidermal_growth_factor	50,73	polyamines	epidermal growth factor	MESH:D011073	25313(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY induced|nsubj|Role induced|nmod|END_ENTITY	Role of polyamines in gastroprotection induced by epidermal_growth_factor .
2496768	0	polyamines	65,75	epidermal_growth_factor	103,126	polyamines	epidermal growth factor	MESH:D011073	1950	Chemical	Gene	START_ENTITY|nmod|effect effect|nmod|END_ENTITY	-LSB- Effect of inhibitors of polyamine biosynthesis and of exogenous polyamines on the mitogenic effect of epidermal_growth_factor in a hepatocyte culture -RSB- .
6357086	0	polyamines	10,20	glucose-6-phosphate_dehydrogenase	66,99	polyamines	glucose-6-phosphate dehydrogenase	MESH:D011073	855480(Tax:4932)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of polyamines on palmitoyl-coenzyme A-caused inhibition of glucose-6-phosphate_dehydrogenase from baker 's _ yeast .
7451229	0	polyamines	41,51	growth_hormone	17,31	polyamines	growth hormone	MESH:D011073	2688	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of human growth_hormone on blood polyamines in hypopituitarism .
11271933	0	polyamines	17,27	gyrate_atrophy	31,45	polyamines	gyrate atrophy	MESH:D011073	4942	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Possible role of polyamines in gyrate_atrophy .
15955070	0	polyamines	83,93	interferon_regulatory_factor_3	29,59	polyamines	interferon regulatory factor 3	MESH:D011073	3661	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of arginase II by interferon_regulatory_factor_3 and the involvement of polyamines in the antiviral response .
244419	0	polyamines	10,20	isoleucyl-tRNA_synthetase	62,87	polyamines	isoleucyl-tRNA synthetase	MESH:D011073	306804(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of polyamines on isoleucyl-tRNA formation by rat-liver isoleucyl-tRNA_synthetase .
15539552	0	polyamines	127,137	ornithine_aminotransferase	28,54	polyamines	ornithine aminotransferase	MESH:D011073	18242(Tax:10090)	Chemical	Gene	synthesis|amod|START_ENTITY END_ENTITY|nmod|synthesis	Testosterone down-regulates ornithine_aminotransferase gene and up-regulates arginase II and ornithine_decarboxylase genes for polyamines synthesis in the murine kidney .
10564512	0	polyamines	19,29	ornithine_decarboxylase	85,108	polyamines	ornithine decarboxylase	MESH:D011073	4953	Chemical	Gene	levels|nmod|START_ENTITY levels|acl|resulting resulting|nmod|overexpression overexpression|nmod|gene gene|amod|END_ENTITY	Elevated levels of polyamines and trypanothione resulting from overexpression of the ornithine_decarboxylase gene in arsenite-resistant Leishmania .
11513732	0	polyamines	146,156	ornithine_decarboxylase	29,52	polyamines	ornithine decarboxylase	MESH:D011073	18263(Tax:10090)	Chemical	Gene	catabolism|nmod|START_ENTITY accelerates|dobj|catabolism overexpression|parataxis|accelerates overexpression|nmod|N N|amod|END_ENTITY	Concurrent overexpression of ornithine_decarboxylase and spermidine/spermine _ N -LRB- 1 -RRB- - acetyltransferase further accelerates the catabolism of hepatic polyamines in transgenic_mice .
12716758	0	polyamines	101,111	ornithine_decarboxylase	24,47	polyamines	ornithine decarboxylase	MESH:D011073	24609(Tax:10116)	Chemical	Gene	paracrine|nsubj|START_ENTITY paracrine|dep|expression expression|nmod|END_ENTITY	Increased expression of ornithine_decarboxylase in distal tubules of early diabetic rat kidneys : are polyamines paracrine hypertrophic factors ?
14600289	0	polyamines	107,117	ornithine_decarboxylase	43,66	polyamines	ornithine decarboxylase	MESH:D011073	24609(Tax:10116)	Chemical	Gene	tyrosine|dobj|START_ENTITY tyrosine|nsubj|changes changes|nmod|END_ENTITY	Hexachlorobenzene-induced early changes in ornithine_decarboxylase and protein tyrosine kinase activities , polyamines and c-Myc , c-Fos and c-Jun proto-oncogenes in rat liver .
1932110	0	polyamines	70,80	ornithine_decarboxylase	32,55	polyamines	ornithine decarboxylase	MESH:D011073	18263(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	On the translational control of ornithine_decarboxylase expression by polyamines .
3134356	0	polyamines	102,112	ornithine_decarboxylase	11,34	polyamines	ornithine decarboxylase	MESH:D011073	18263(Tax:10090)	Chemical	Gene	Control|nmod|START_ENTITY Control|nmod|activity activity|amod|END_ENTITY	Control of ornithine_decarboxylase activity in alpha-difluoromethylornithine-resistant L1210 cells by polyamines and synthetic analogues .
3743773	0	polyamines	55,65	ornithine_decarboxylase	28,51	polyamines	ornithine decarboxylase	MESH:D011073	4953	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Translational regulation of ornithine_decarboxylase by polyamines .
3818602	0	polyamines	105,115	ornithine_decarboxylase	39,62	polyamines	ornithine decarboxylase	MESH:D011073	4953	Chemical	Gene	decarboxylase|nmod|START_ENTITY decarboxylase|nsubj|Inhibition Inhibition|nmod|translation translation|nmod|mRNAs mRNAs|nmod|END_ENTITY	Inhibition of translation of mRNAs for ornithine_decarboxylase and S-adenosylmethionine decarboxylase by polyamines .
3934157	0	polyamines	65,75	ornithine_decarboxylase	38,61	polyamines	ornithine decarboxylase	MESH:D011073	4953	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Translational regulation of mammalian ornithine_decarboxylase by polyamines .
457786	0	polyamines	66,76	ornithine_decarboxylase	28,51	polyamines	ornithine decarboxylase	MESH:D011073	24609(Tax:10116)	Chemical	Gene	mechanisms|nmod|START_ENTITY mechanisms|nmod|regulation regulation|amod|END_ENTITY	Two distinct mechanisms for ornithine_decarboxylase regulation by polyamines in rat hepatoma cells .
6217347	0	polyamines	8,18	ornithine_decarboxylase	136,159	polyamines	ornithine decarboxylase	MESH:D011073	4953	Chemical	Gene	Role|nmod|START_ENTITY Role|dep|effects effects|nmod|alpha-difluoromethylornithine alpha-difluoromethylornithine|appos|inhibitor inhibitor|nmod|END_ENTITY	Role of polyamines in isoproterenol-induced cardiac_hypertrophy : effects of alpha-difluoromethylornithine , an irreversible inhibitor of ornithine_decarboxylase .
7106211	0	polyamines	73,83	ornithine_decarboxylase	27,50	polyamines	ornithine decarboxylase	MESH:D011073	24609(Tax:10116)	Chemical	Gene	Activity|nmod|START_ENTITY Activity|nmod|END_ENTITY	Activity and modulation of ornithine_decarboxylase and concentrations of polyamines in various tissues of rats as a function of age .
8095973	0	polyamines	141,151	ornithine_decarboxylase	13,36	polyamines	ornithine decarboxylase	MESH:D011073	24609(Tax:10116)	Chemical	Gene	potentiation|nmod|START_ENTITY unrelated|xcomp|potentiation unrelated|nsubj|Induction Induction|nmod|END_ENTITY	Induction of ornithine_decarboxylase by N-methyl-D-aspartate receptor activation is unrelated to potentiation of glutamate excitotoxicity by polyamines in cerebellar granule neurons .
8354641	0	polyamines	57,67	ornithine_decarboxylase	14,37	polyamines	ornithine decarboxylase	MESH:D011073	4953	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|decreases decreases|amod|END_ENTITY	Inhibition of ornithine_decarboxylase activity decreases polyamines and suppresses DNA synthesis in human colonic lamina propria lymphocytes .
8499611	0	polyamines	23,33	ornithine_decarboxylase	81,104	polyamines	ornithine decarboxylase	MESH:D011073	18263(Tax:10090)	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|cDNA cDNA|compound|END_ENTITY	Modulation of cellular polyamines in tobacco by transfer and expression of mouse ornithine_decarboxylase cDNA .
8706937	0	polyamines	117,127	ornithine_decarboxylase	45,68	polyamines	ornithine decarboxylase	MESH:D011073	4953	Chemical	Gene	control|nmod|START_ENTITY control|nmod|END_ENTITY	Differential post-transcriptional control of ornithine_decarboxylase and spermidine-spermine_N1-acetyltransferase by polyamines .
9756034	0	polyamines	106,116	ornithine_decarboxylase	45,68	polyamines	ornithine decarboxylase	MESH:D011073	24609(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY implications|nmod|role leads|dobj|implications leads|nmod|activity activity|compound|END_ENTITY	Chronic ethanol treatment leads to increased ornithine_decarboxylase activity : implications for a role of polyamines in ethanol dependence and withdrawal .
1877375	0	polyamines	15,25	parathyroid_hormone	56,75	polyamines	parathyroid hormone	MESH:D011073	19226(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY induced|nsubj|role induced|nmod|END_ENTITY	On the role of polyamines in bone resorption induced by parathyroid_hormone .
8916930	0	polyamines	11,21	spermidine-spermine_N1-acetyltransferase	81,121	polyamines	spermidine-spermine N1-acetyltransferase	MESH:D011073	6303	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|amod|END_ENTITY	Effects of polyamines , polyamine analogs , and inhibitors of protein synthesis on spermidine-spermine_N1-acetyltransferase gene expression .
8492070	0	polyamines	31,41	thyrotrophin-releasing_hormone	93,123	polyamines	thyrotrophin-releasing hormone	MESH:D011073	25569(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY induced|nsubj|role induced|nmod|END_ENTITY	Pro-oestrous-specific role for polyamines in mediating the secretion of prolactin induced by thyrotrophin-releasing_hormone in the rat .
3125836	0	polyamines	14,24	tyrosinase	28,38	polyamines	tyrosinase	MESH:D011073	7299	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|amod|END_ENTITY	The effect of polyamines on tyrosinase activity .
20493127	0	polyamines	11,21	tyrosine_hydroxylase	25,45	polyamines	tyrosine hydroxylase	MESH:D011073	7054	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effects of polyamines on tyrosine_hydroxylase activity in adrenals .
8307001	0	polyamines	19,29	vitamin_D_receptor	51,69	polyamines	vitamin D receptor	MESH:D011073	7421	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	The involvement of polyamines in the activation of vitamin_D_receptor from porcine intestinal mucosa .
26864392	0	polycarbazole	57,70	CO2	85,88	polycarbazole	CO2	CHEBI:60506	717	Chemical	Gene	START_ENTITY|nmod|capture capture|compound|END_ENTITY	Rational design and synthesis of a porous , task-specific polycarbazole for efficient CO2 capture .
10919282	0	polychlorinated_aromatic_hydrocarbons	32,69	cholecystokinin	84,99	polychlorinated aromatic hydrocarbons	cholecystokinin	null	25298(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nsubj|effects	Endocrine disruptive effects of polychlorinated_aromatic_hydrocarbons on intestinal cholecystokinin in rats .
15755030	0	polychlorinated_biphenyl	12,36	bcl-2	40,45	polychlorinated biphenyl	bcl-2	null	24224(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effects of polychlorinated_biphenyl on bcl-2 and TGFbeta1 expression in rat testes -RSB- .
22611921	0	polychlorinated_biphenyl	12,36	c-fos	58,63	polychlorinated biphenyl	c-fos	null	314322(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of polychlorinated_biphenyl on the expression of c-fos and c-jun in mesenchymal cells of rats -RSB- .
9624420	0	polychlorinated_biphenyl	56,80	insulin-like_growth_factor	18,44	polychlorinated biphenyl	insulin-like growth factor	null	3481	Chemical	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Expression of the insulin-like_growth_factor II gene in polychlorinated_biphenyl exposed female mink -LRB- Mustela vison -RRB- and their fetuses .
23907094	0	polychlorinated_biphenyls	32,57	Androgen_receptor	0,17	polychlorinated biphenyls	Androgen receptor	MESH:D011078	367	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Androgen_receptor activation by polychlorinated_biphenyls : epigenetic effects mediated by the histone demethylase Jarid1b .
7704189	0	polychlorinated_biphenyls	69,94	C18	26,29	polychlorinated biphenyls	C18	MESH:D011078	27241	Chemical	Gene	extraction|nmod|START_ENTITY extraction|nmod|END_ENTITY	Solid-phase extraction on C18 in the trace determination of selected polychlorinated_biphenyls in milk .
22157103	0	polychlorinated_biphenyls	11,36	CD-1	40,44	polychlorinated biphenyls	CD-1	MESH:D011078	111334(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|compound|END_ENTITY	Effects of polychlorinated_biphenyls in CD-1 mice : reproductive toxicity and intergenerational transmission .
22326254	0	polychlorinated_biphenyls	31,56	IL-8	62,66	polychlorinated biphenyls	IL-8	MESH:D011078	3576	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Association of serum levels of polychlorinated_biphenyls with IL-8 mRNA expression in blood samples from asthmatic and non-asthmatic Japanese children .
19332547	0	polychlorinated_biphenyls	61,86	aquaporin_1	18,29	polychlorinated biphenyls	aquaporin 1	MESH:D011078	11826(Tax:10090)	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	The water channel aquaporin_1 is a novel molecular target of polychlorinated_biphenyls for in utero_anomalies .
3103261	0	polychlorinated_biphenyls	67,92	cytochrome_P-450	26,42	polychlorinated biphenyls	cytochrome P-450	MESH:D011078	13079(Tax:10090)	Chemical	Gene	activities|nmod|START_ENTITY activities|amod|END_ENTITY	Differential induction of cytochrome_P-450 catalyzed activities by polychlorinated_biphenyls and benzo _ -LSB- a -RSB- pyrene in B6C3F1 mouse liver and lung .
18398048	0	polychlorinated_biphenyls	22,47	cytochrome_P4501A2	76,94	polychlorinated biphenyls	cytochrome P4501A2	MESH:D011078	1544	Chemical	Gene	START_ENTITY|nmod|biomarker biomarker|nmod|activity activity|amod|END_ENTITY	The ratio of specific polychlorinated_biphenyls as a surrogate biomarker of cytochrome_P4501A2 activity : a pharmaco-metabonomic study in humans .
9173681	0	polychlorinated_biphenyls	53,78	cytochrome_b5	8,21	polychlorinated biphenyls	cytochrome b5	MESH:D011078	64001(Tax:10116)	Chemical	Gene	metabolism|nmod|START_ENTITY END_ENTITY|nmod|metabolism	Role of cytochrome_b5 in the oxidative metabolism of polychlorinated_biphenyls catalyzed by cytochrome_P450 .
24508592	0	polychlorinated_biphenyls	37,62	hSULT2A1	115,123	polychlorinated biphenyls	hSULT2A1	MESH:D011078	6822	Chemical	Gene	interactions|nmod|START_ENTITY interactions|nmod|END_ENTITY	Binding interactions of hydroxylated polychlorinated_biphenyls -LRB- OHPCBs -RRB- with human hydroxysteroid sulfotransferase hSULT2A1 .
6412664	0	polychlorinated_dibenzofurans	23,52	aryl_hydrocarbon_hydroxylase	123,151	polychlorinated dibenzofurans	aryl hydrocarbon hydroxylase	MESH:C023386	24296(Tax:10116)	Chemical	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	A comparative study of polychlorinated_dibenzofurans , polychlorinated_biphenyls and 2,3,7,8-tetrachlorodibenzo-p-dioxin on aryl_hydrocarbon_hydroxylase inducing potency in rats .
25141271	0	polychlorinated_diphenylsulfides	90,122	aryl_hydrocarbon_receptor	20,45	polychlorinated diphenylsulfides	aryl hydrocarbon receptor	null	373907(Tax:9031)	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of avian aryl_hydrocarbon_receptor and inter-species sensitivity variations by polychlorinated_diphenylsulfides .
10581206	0	polycyclic_aromatic_acetylene	17,46	CYP1B1	61,67	polycyclic aromatic acetylene	CYP1B1	null	13078(Tax:10090)	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	Metabolism-based polycyclic_aromatic_acetylene inhibition of CYP1B1 in 10T1/2 cells potentiates aryl_hydrocarbon_receptor activity .
9509414	0	polycyclic_aromatic_hydrocarbon	57,88	FMO1	46,50	polycyclic aromatic hydrocarbon	FMO1	null	25256(Tax:10116)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of flavin-containing_monooxygenase -LRB- FMO1 -RRB- by a polycyclic_aromatic_hydrocarbon , 3-methylcholanthrene , in rat liver .
9622076	0	polycyclic_aromatic_hydrocarbon	125,156	aryl_hydrocarbon_receptor	96,121	polycyclic aromatic hydrocarbon	aryl hydrocarbon receptor	null	196	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	Characterization of CYP1B1 and CYP1A1 expression in human mammary epithelial cells : role of the aryl_hydrocarbon_receptor in polycyclic_aromatic_hydrocarbon metabolism .
17082565	0	polycyclic_aromatic_hydrocarbon	25,56	cyclooxygenase-2	89,105	polycyclic aromatic hydrocarbon	cyclooxygenase-2	null	5743	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	An environmental quinoid polycyclic_aromatic_hydrocarbon , acenaphthenequinone , modulates cyclooxygenase-2 expression through reactive oxygen species generation and nuclear_factor_kappa_B activation in A549 cells .
7344478	0	polycyclic_aromatic_hydrocarbon	64,95	cytochrome_P-450	40,56	polycyclic aromatic hydrocarbon	cytochrome P-450	null	4051	Chemical	Gene	substrates|compound|START_ENTITY END_ENTITY|nmod|substrates	Regio - and stereoselectivity of hepatic cytochrome_P-450 toward polycyclic_aromatic_hydrocarbon substrates .
9509414	0	polycyclic_aromatic_hydrocarbon	57,88	flavin-containing_monooxygenase	13,44	polycyclic aromatic hydrocarbon	flavin-containing monooxygenase	null	25256(Tax:10116)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of flavin-containing_monooxygenase -LRB- FMO1 -RRB- by a polycyclic_aromatic_hydrocarbon , 3-methylcholanthrene , in rat liver .
24203299	0	polycyclic_aromatic_hydrocarbons	49,81	C10	36,39	polycyclic aromatic hydrocarbons	C10	MESH:D011084	3226	Chemical	Gene	START_ENTITY|nsubj|Characterization Characterization|nmod|END_ENTITY	Characterization of flame-generated C10 to C 160 polycyclic_aromatic_hydrocarbons by atmospheric-pressure chemical ionization mass spectrometry with liquid introduction via heated nebulizer interface .
8674863	0	polycyclic_aromatic_hydrocarbons	99,131	CYP1A1	12,18	polycyclic aromatic hydrocarbons	CYP1A1	MESH:D011084	24296(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY END_ENTITY|dep|expression	Cytochromes CYP1A1 and CYP1B1 in the rat mammary gland : cell-specific expression and regulation by polycyclic_aromatic_hydrocarbons and hormones .
12398325	0	polycyclic_aromatic_hydrocarbons	74,106	Cytochrome_P450_1B1	0,19	polycyclic aromatic hydrocarbons	Cytochrome P450 1B1	MESH:D011084	1545	Chemical	Gene	levels|nmod|START_ENTITY levels|amod|END_ENTITY	Cytochrome_P450_1B1 mRNA levels in peripheral blood cells and exposure to polycyclic_aromatic_hydrocarbons in Chinese coke oven workers .
19548353	0	polycyclic_aromatic_hydrocarbons	15,47	P450_1B1	70,78	polycyclic aromatic hydrocarbons	P450 1B1	MESH:D011084	1545	Chemical	Gene	Interaction|nmod|START_ENTITY END_ENTITY|nsubj|Interaction	Interaction of polycyclic_aromatic_hydrocarbons with human cytochrome P450_1B1 in inhibiting catalytic activity .
12799773	0	polycyclic_aromatic_hydrocarbons	69,101	aryl_hydrocarbon_receptor	10,35	polycyclic aromatic hydrocarbons	aryl hydrocarbon receptor	MESH:D011084	196	Chemical	Gene	effects|nmod|START_ENTITY role|nmod|effects role|nmod|END_ENTITY	A role of aryl_hydrocarbon_receptor in the antiandrogenic effects of polycyclic_aromatic_hydrocarbons in LNCaP human prostate_carcinoma cells .
2775307	1	polycyclic_aromatic_hydrocarbons	68,100	cytochrome_P-450	104,120	polycyclic aromatic hydrocarbons	cytochrome P-450	MESH:D011084	25251(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|regulation regulation|amod|END_ENTITY	Effect of polycyclic_aromatic_hydrocarbons on cytochrome_P-450 regulation .
6317209	0	polycyclic_aromatic_hydrocarbons	64,96	cytochrome_P-450	116,132	polycyclic aromatic hydrocarbons	cytochrome P-450	MESH:D011084	25251(Tax:10116)	Chemical	Gene	Enhancement|nmod|START_ENTITY Enhancement|nmod|END_ENTITY	Enhancement of DNA binding , mutagenicity and carcinogenicity of polycyclic_aromatic_hydrocarbons after induction of cytochrome_P-450 by ellipticines in rats and mice .
8579379	0	polycyclic_aromatic_hydrocarbons	106,138	cytochrome_P450IA1	27,45	polycyclic aromatic hydrocarbons	cytochrome P450IA1	MESH:D011084	1543	Chemical	Gene	levels|nmod|START_ENTITY levels|nmod|END_ENTITY	Liver microsomal levels of cytochrome_P450IA1 as biomarker for exposure and bioavailability of soil-bound polycyclic_aromatic_hydrocarbons .
18284927	0	polycyclic_aromatic_hydrocarbons	11,43	odorant-binding_protein	58,81	polycyclic aromatic hydrocarbons	odorant-binding protein	MESH:D011084	396704(Tax:9823)	Chemical	Gene	START_ENTITY|nmod|mutants mutants|nmod|END_ENTITY	Binding of polycyclic_aromatic_hydrocarbons to mutants of odorant-binding_protein : a first step towards biosensors for environmental monitoring .
16427050	0	polycyclic_aromatic_hydrocarbons	66,98	p53	14,17	polycyclic aromatic hydrocarbons	p53	MESH:D011084	7157	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Activation Activation|nmod|END_ENTITY	Activation of p53 as a causal step for atherosclerosis induced by polycyclic_aromatic_hydrocarbons .
16451085	0	polycyclic_aza-amide	52,72	FKBP12	73,79	polycyclic aza-amide	FKBP12	null	2285	Chemical	Gene	ligands|amod|START_ENTITY ligands|compound|END_ENTITY	Design , synthesis , and biological activity of novel polycyclic_aza-amide FKBP12 ligands .
7744798	0	polycyclic_hydrocarbon	58,80	CYP1B1	99,105	polycyclic hydrocarbon	CYP1B1	CHEBI:33666	25426(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|nmod|END_ENTITY	Identification of a rat adrenal cytochrome P450 active in polycyclic_hydrocarbon metabolism as rat CYP1B1 .
22802962	0	polycystin-2	52,64	filamin	68,75	polycystin-2	filamin	null	2318	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Structural interaction and functional regulation of polycystin-2 by filamin .
25509306	0	polydatin	22,31	toll-like_receptor_4	49,69	polydatin	toll-like receptor 4	MESH:C058229	29260(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Inhibitory effect of polydatin on expression of toll-like_receptor_4 in ischemia-reperfusion injured NRK-52E cells -RSB- .
4711378	0	polyene-phosphatidyl-choline	105,133	familial_hypercholesterolemia	48,77	polyene-phosphatidyl-choline	familial hypercholesterolemia	MESH:C029449	3949	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|dep|effect	The coronary syndrome in two cases of essential familial_hypercholesterolemia -LRB- the therapeutic effect of polyene-phosphatidyl-choline -RRB- .
19585564	0	polyester	37,46	BMP-7	17,22	polyester	BMP-7	CHEBI:60160	85272(Tax:10116)	Chemical	Gene	delivery|nmod|START_ENTITY delivery|compound|END_ENTITY	Sequential BMP-2 / BMP-7 delivery from polyester nanocapsules .
21511923	0	polyethylene	33,45	hip	56,59	polyethylene	hip	MESH:D020959	6159	Chemical	Gene	START_ENTITY|nmod|replacement replacement|compound|END_ENTITY	Cross-linked versus conventional polyethylene for total hip replacement : a meta-analysis of randomised controlled trials .
22576119	0	polyethylene_glycol	33,52	CD11b	74,79	polyethylene glycol	CD11b	MESH:D011092	3684	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effects of cryopreservation with polyethylene_glycol on the expression of CD11b and CD62L on the surface of polymorphonuclear leukocytes .
118838	0	polyethylene_glycol	20,39	Conglutinin	0,11	polyethylene glycol	Conglutinin	MESH:D011092	281068(Tax:9913)	Chemical	Gene	START_ENTITY|nsubj|binding binding|compound|END_ENTITY	Conglutinin binding polyethylene_glycol precipitation assay for immune complexes .
531491	0	polyethylene_glycol	8,27	gastric_intrinsic_factor	38,62	polyethylene glycol	gastric intrinsic factor	MESH:D011092	2694	Chemical	Gene	assay|amod|START_ENTITY assay|nmod|END_ENTITY	A rapid polyethylene_glycol assay for gastric_intrinsic_factor .
9387313	0	polyethylene_glycol	30,49	interleukin-2	78,91	polyethylene glycol	interleukin-2	MESH:D011092	3558	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|END_ENTITY	-LSB- In vivo antitumor effects of polyethylene_glycol -- modified recombinant human interleukin-2 on mouse uterine cervical carcinoma -RSB- .
699287	0	polyethylene_glycol	7,26	placental_lactogen	56,74	polyethylene glycol	placental lactogen	MESH:D011092	1443	Chemical	Gene	Use|nmod|START_ENTITY Use|nmod|END_ENTITY	Use of polyethylene_glycol in radioimmunoassay of human placental_lactogen .
8874022	0	polyethylene_glycol_8000	27,51	gelsolin	83,91	polyethylene glycol 8000	gelsolin	MESH:D011092	2934	Chemical	Gene	START_ENTITY|nmod|presence presence|nmod|END_ENTITY	The bundling of actin with polyethylene_glycol_8000 in the presence and absence of gelsolin .
2642704	0	polyethylene_glycols	13,33	alcohol_dehydrogenase	37,58	polyethylene glycols	alcohol dehydrogenase	MESH:D011092	10327	Chemical	Gene	Oxidation|nmod|START_ENTITY Oxidation|nmod|END_ENTITY	Oxidation of polyethylene_glycols by alcohol_dehydrogenase .
15348300	0	polyethylene_terephthalate	91,117	Interleukin-6	0,13	polyethylene terephthalate	Interleukin-6	MESH:C501560	3569	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Interleukin-6 expression by cultured human endothelial cells in contact with carbon coated polyethylene_terephthalate .
18256079	0	polyethylenes	4,17	hip	27,30	polyethylenes	hip	MESH:D011095	6767	Chemical	Gene	START_ENTITY|nmod|replacement replacement|compound|END_ENTITY	New polyethylenes in total hip replacement : a prospective , comparative clinical study of two types of liner .
24917027	0	polyethylenimine	64,80	RAGE	27,31	polyethylenimine	RAGE	MESH:D011094	81722(Tax:10116)	Chemical	Gene	complexes|compound|START_ENTITY complexes|amod|END_ENTITY	Cardiac RNAi therapy using RAGE siRNA/deoxycholic _ acid-modified polyethylenimine complexes for myocardial_infarction .
19913908	0	polyethylenimine	105,121	STAT3	59,64	polyethylenimine	STAT3	MESH:D011094	6774	Chemical	Gene	delivery|nmod|START_ENTITY delivery|compound|END_ENTITY	The induction of tumor apoptosis in B16_melanoma following STAT3 siRNA delivery with a lipid-substituted polyethylenimine .
21314600	0	polyglutamic_acid	110,127	histone_H1	74,84	polyglutamic acid	histone H1	MESH:D011099	24437(Tax:10116)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of distamycin , chromomycin , and UV-irradiation on extraction of histone_H1 from rat liver nuclei by polyglutamic_acid .
15900600	0	polyglutamine	60,73	AIB1	95,99	polyglutamine	AIB1	MESH:C097188	116833	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Breast_cancer risk in BRCA1 and BRCA2 mutation carriers and polyglutamine repeat length in the AIB1 gene .
25263716	0	polyglutamine	14,27	AIB1	4,8	polyglutamine	AIB1	MESH:C097188	116833	Chemical	Gene	polymorphism|amod|START_ENTITY polymorphism|compound|END_ENTITY	The AIB1 gene polyglutamine repeat length polymorphism contributes to risk of epithelial_ovarian_cancer risk : a case-control study .
10556285	0	polyglutamine	55,68	Ataxin-3	0,8	polyglutamine	Ataxin-3	MESH:C097188	4287	Chemical	Gene	domain|amod|START_ENTITY exposes|dobj|domain conformation|acl:relcl|exposes END_ENTITY|nmod|conformation	Ataxin-3 with an altered conformation that exposes the polyglutamine domain is associated with the nuclear matrix .
15808507	0	polyglutamine	20,33	Ataxin-3	0,8	polyglutamine	Ataxin-3	MESH:C097188	4287	Chemical	Gene	START_ENTITY|nsubj|suppresses suppresses|amod|END_ENTITY	Ataxin-3 suppresses polyglutamine neurodegeneration in Drosophila by a ubiquitin-associated mechanism .
15664989	0	polyglutamine	43,56	CHIP	13,17	polyglutamine	CHIP	MESH:C097188	358	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|nmod|protein	Co-chaperone CHIP associates with expanded polyglutamine protein and promotes their degradation by proteasomes .
10332031	0	polyglutamine	70,83	DRPLA	41,46	polyglutamine	DRPLA	MESH:C097188	29515(Tax:10116)	Chemical	Gene	proteins|nmod|START_ENTITY proteins|compound|END_ENTITY	Adenovirus-mediated expression of mutant DRPLA proteins with expanded polyglutamine stretches in neuronally differentiated PC12 cells .
9705838	0	polyglutamine	108,121	DRPLA	75,80	polyglutamine	DRPLA	MESH:C097188	1822	Chemical	Gene	protein|nmod|START_ENTITY protein|appos|END_ENTITY	Intracellular aggregate formation of dentatorubral-pallidoluysian_atrophy -LRB- DRPLA -RRB- protein with the extended polyglutamine .
20399836	0	polyglutamine	6,19	POLG1	0,5	polyglutamine	POLG1	MESH:C097188	5428	Chemical	Gene	variants|compound|START_ENTITY variants|compound|END_ENTITY	POLG1 polyglutamine tract variants associated with Parkinson 's _ disease .
10332029	0	polyglutamine	16,29	PQBP-1	0,6	polyglutamine	PQBP-1	MESH:C097188	54633(Tax:10090)	Chemical	Gene	protein|amod|START_ENTITY END_ENTITY|appos|protein	PQBP-1 , a novel polyglutamine tract-binding protein , inhibits transcription activation by Brn-2 and affects cell survival .
10873650	0	polyglutamine	47,60	PQBP-1	0,6	polyglutamine	PQBP-1	MESH:C097188	10084	Chemical	Gene	tract|amod|START_ENTITY binding|nmod|tract protein|amod|binding Npw38|appos|protein interacts|nsubj|Npw38 END_ENTITY|appos|interacts	PQBP-1 / Npw38 , a nuclear protein binding to the polyglutamine tract , interacts with U5-15kD / dim1p via the carboxyl-terminal domain .
23022625	0	polyglutamine	23,36	PQBP-1	55,61	polyglutamine	PQBP-1	MESH:C097188	10084	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Comparative aspects of polyglutamine binding domain in PQBP-1 among Vertebrata .
14698481	0	polyglutamine	14,27	androgen_receptor	51,68	polyglutamine	androgen receptor	MESH:C097188	367	Chemical	Gene	expansion|amod|START_ENTITY expansion|nmod|END_ENTITY	The effect of polyglutamine expansion in the human androgen_receptor on its ability to suppress beta-catenin-Tcf/Lef dependent transcription .
14966121	0	polyglutamine	51,64	androgen_receptor	33,50	polyglutamine	androgen receptor	MESH:C097188	367	Chemical	Gene	START_ENTITY|nsubj|relationship relationship|nmod|END_ENTITY	Mechanistic relationship between androgen_receptor polyglutamine tract truncation and androgen-dependent transcriptional hyperactivity in prostate_cancer cells .
19237573	0	polyglutamine	27,40	androgen_receptor	54,71	polyglutamine	androgen receptor	MESH:C097188	367	Chemical	Gene	expansion|amod|START_ENTITY expansion|nmod|END_ENTITY	Aberrant E2F activation by polyglutamine expansion of androgen_receptor in SBMA_neurotoxicity .
9111734	0	polyglutamine	29,42	androgen_receptor	11,28	polyglutamine	androgen receptor	MESH:C097188	11835(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of androgen_receptor polyglutamine tract expansion on proliferation of NG108-15 cells .
10023088	0	polyglutamine	43,56	ataxin-3	143,151	polyglutamine	ataxin-3	MESH:C097188	378424(Tax:9031)	Chemical	Gene	polymorphism|amod|START_ENTITY evidence|nmod|polymorphism lack|nmod|evidence END_ENTITY|dep|lack	Conserved domains and lack of evidence for polyglutamine length polymorphism in the chicken homolog of the Machado-Joseph_disease gene product ataxin-3 .
11561037	0	polyglutamine	61,74	ataxin-3	28,36	polyglutamine	ataxin-3	MESH:C097188	4287	Chemical	Gene	independent|nmod|START_ENTITY independent|amod|END_ENTITY	Preferential recruitment of ataxin-3 independent of expanded polyglutamine : an immunohistochemical study on Marinesco bodies .
12646686	0	polyglutamine	43,56	ataxin-3	95,103	polyglutamine	ataxin-3	MESH:C097188	4287	Chemical	Gene	tract|compound|START_ENTITY mutagenesis|nmod|tract mutagenesis|dep|application application|acl|spinocerebellar spinocerebellar|xcomp|END_ENTITY	Site-specific mutagenesis in a homogeneous polyglutamine tract : application to spinocerebellar ataxin-3 .
14602712	0	polyglutamine	30,43	ataxin-3	60,68	polyglutamine	ataxin-3	MESH:C097188	4287	Chemical	Gene	disease|amod|START_ENTITY binding|nmod|disease END_ENTITY|amod|binding	Poly-ubiquitin binding by the polyglutamine disease protein ataxin-3 links its normal function to protein surveillance pathways .
14659761	0	polyglutamine	148,161	ataxin-3	49,57	polyglutamine	ataxin-3	MESH:C097188	4287	Chemical	Gene	disease|amod|START_ENTITY misfolding|nmod|disease model|acl|misfolding intermediate|dep|model Destabilization|nmod|intermediate Destabilization|nmod|results results|amod|END_ENTITY	Destabilization of a non-pathological variant of ataxin-3 results in fibrillogenesis via a partially folded intermediate : a model for misfolding in polyglutamine disease .
14661975	0	polyglutamine	124,137	ataxin-3	84,92	polyglutamine	ataxin-3	MESH:C097188	4287	Chemical	Gene	stretch|amod|START_ENTITY stretch|nsubj|formation formation|nmod|fibrils fibrils|nmod|carrying carrying|amod|END_ENTITY	Temperature-dependent , irreversible formation of amyloid fibrils by a soluble human ataxin-3 carrying a moderately expanded polyglutamine stretch -LRB- Q36 -RRB- .
15325242	0	polyglutamine	65,78	ataxin-3	87,95	polyglutamine	ataxin-3	MESH:C097188	4287	Chemical	Gene	protein|amod|START_ENTITY domain|nmod|protein analysis|nmod|domain analysis|amod|END_ENTITY	Structural and functional analysis of the Josephin domain of the polyglutamine protein ataxin-3 .
16040601	0	polyglutamine	57,70	ataxin-3	88,96	polyglutamine	ataxin-3	MESH:C097188	4287	Chemical	Gene	protein|amod|START_ENTITY motifs|nmod|protein role|nmod|motifs END_ENTITY|dep|role	Defining the role of ubiquitin-interacting motifs in the polyglutamine disease protein , ataxin-3 .
17302910	0	polyglutamine	58,71	ataxin-3	88,96	polyglutamine	ataxin-3	MESH:C097188	4287	Chemical	Gene	protein|amod|START_ENTITY END_ENTITY|nsubj|protein	p45 , an ATPase subunit of the 19S proteasome , targets the polyglutamine disease protein ataxin-3 to the proteasome .
17362987	0	polyglutamine	97,110	ataxin-3	14,22	polyglutamine	ataxin-3	MESH:C097188	4287	Chemical	Gene	protein|compound|START_ENTITY analysis|nmod|protein Mechanisms|dep|analysis Mechanisms|nmod|misfolding misfolding|amod|END_ENTITY	Mechanisms of ataxin-3 misfolding and fibril formation : kinetic analysis of a disease-associated polyglutamine protein .
18599482	0	polyglutamine	40,53	ataxin-3	28,36	polyglutamine	ataxin-3	MESH:C097188	4287	Chemical	Gene	protein|amod|START_ENTITY END_ENTITY|appos|protein	The deubiquitinating enzyme ataxin-3 , a polyglutamine disease protein , edits Lys63 linkages in mixed linkage ubiquitin chains .
21060878	0	polyglutamine	23,36	ataxin-3	53,61	polyglutamine	ataxin-3	MESH:C097188	4287	Chemical	Gene	protein|amod|START_ENTITY isoforms|nmod|protein isoforms|dep|exhibit exhibit|amod|END_ENTITY	Splice isoforms of the polyglutamine disease protein ataxin-3 exhibit similar enzymatic yet different aggregation properties .
23955261	0	polyglutamine	44,57	ataxin-3	7,15	polyglutamine	ataxin-3	MESH:C097188	110616(Tax:10090)	Chemical	Gene	chain|compound|START_ENTITY END_ENTITY|nmod|chain	Mutant ataxin-3 with an abnormally expanded polyglutamine chain disrupts dendritic development and metabotropic glutamate receptor signaling in mouse cerebellar Purkinje cells .
25143392	0	polyglutamine	28,41	ataxin-3	80,88	polyglutamine	ataxin-3	MESH:C097188	110616(Tax:10090)	Chemical	Gene	expansion|amod|START_ENTITY effect|nmod|expansion perturbs|nsubj|effect perturbs|dobj|function function|nmod|END_ENTITY	Dominant negative effect of polyglutamine expansion perturbs normal function of ataxin-3 in neuronal cells .
25700012	0	polyglutamine	123,136	ataxin-3	15,23	polyglutamine	ataxin-3	MESH:C097188	4287	Chemical	Gene	expansion|amod|START_ENTITY aggregation|nmod|expansion rationale|nmod|aggregation Examination|dep|rationale Examination|nmod|aggregation aggregation|amod|END_ENTITY	Examination of ataxin-3 aggregation by structural mass spectrometry techniques : A rationale for expedited aggregation upon polyglutamine expansion .
10749676	0	polyhistidine	26,39	Thrombospondin-1	0,16	polyhistidine	Thrombospondin-1	null	7057	Chemical	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	Thrombospondin-1 binds to polyhistidine with high affinity and specificity .
23967118	0	polyhydroxylated_alkaloids	14,40	maltase-glucoamylase	44,64	polyhydroxylated alkaloids	maltase-glucoamylase	null	8972	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of polyhydroxylated_alkaloids on maltase-glucoamylase .
8956073	0	polyhydroxymonoamide	8,28	renin	29,34	polyhydroxymonoamide	renin	null	5972	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Several polyhydroxymonoamide renin inhibitors assume similar conformations in the unbound and renin-bound states .
10350605	0	polylysine	11,21	GroEL	25,30	polylysine	GroEL	MESH:D011107	3329	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of polylysine to GroEL .
11007785	0	polylysine	15,25	K-Ras	52,57	polylysine	K-Ras	MESH:D011107	3845	Chemical	Gene	region|compound|START_ENTITY region|nmod|END_ENTITY	The C-terminal polylysine region and methylation of K-Ras are critical for the interaction between K-Ras and microtubules .
24805287	0	polylysine	57,67	VEGF	15,19	polylysine	VEGF	MESH:D011107	7422	Chemical	Gene	START_ENTITY|nsubj|Suppression Suppression|nmod|END_ENTITY	Suppression of VEGF by reversible-PEGylated histidylated polylysine in cancer therapy .
15025528	0	polylysine	71,81	receptor-associated_protein	43,70	polylysine	receptor-associated protein	MESH:D011107	4043	Chemical	Gene	conjugates|compound|START_ENTITY conjugates|amod|END_ENTITY	Gene transfer into human hepatoma cells by receptor-associated_protein / polylysine conjugates .
18053806	0	polymethoxyflavonoid	9,29	MEK	53,56	polymethoxyflavonoid	MEK	null	5609	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|compound|END_ENTITY	A citrus polymethoxyflavonoid , nobiletin , is a novel MEK inhibitor that exhibits antitumor metastasis in human fibrosarcoma HT-1080 cells .
23774476	0	polymethoxyflavonoid	42,62	thioredoxin-interacting_protein	82,113	polymethoxyflavonoid	thioredoxin-interacting protein	null	10628	Chemical	Gene	START_ENTITY|dobj|expression expression|amod|END_ENTITY	Suppressive effect of nobiletin , a citrus polymethoxyflavonoid that downregulates thioredoxin-interacting_protein expression , on tunicamycin-induced apoptosis in SK-N-SH human neuroblastoma cells .
8608324	0	polymyxin-B	79,90	TNF-alpha	41,50	polymyxin-B	TNF-alpha	MESH:D011112	21926(Tax:10090)	Chemical	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Inhibition of lipopolysaccharide-induced TNF-alpha production by semisynthetic polymyxin-B conjugated dextran .
8006310	9	polymyxin_B	1527,1538	IL-6	1497,1501	polymyxin B	IL-6	MESH:D011112	3569	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|release release|compound|END_ENTITY	Furthermore , IL-6 and IL-8 release from human nasal epithelial cell cultures was enhanced by addition to the cultures of lipopolysaccharide , and IL-6 release was inhibited by polymyxin_B .
16542581	0	polymyxin_B	22,33	NF-kappaB	37,46	polymyxin B	NF-kappaB	MESH:D011112	4790	Chemical	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Inhibitory effects of polymyxin_B on NF-kappaB activation and expression of procollagen I , III in pre-eclamptic umbilical artery smooth muscle cells .
17211459	0	polymyxin_B	41,52	P2X7_receptor	14,27	polymyxin B	P2X7 receptor	MESH:D011112	5027	Chemical	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	Modulation of P2X7_receptor functions by polymyxin_B : crucial role of the hydrophobic tail of the antibiotic molecule .
8430940	0	polymyxin_B	93,104	tumor_necrosis_factor-alpha	52,79	polymyxin B	tumor necrosis factor-alpha	MESH:D011112	21926(Tax:10090)	Chemical	Gene	synthesis|nmod|START_ENTITY synthesis|amod|END_ENTITY	Inhibition of lipopolysaccharide-induced macrophage tumor_necrosis_factor-alpha synthesis by polymyxin_B sulfate .
7470604	0	polynucleotide	29,43	growth_hormone	11,25	polynucleotide	growth hormone	CHEBI:15986	81668(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY END_ENTITY|nmod|activity	-LSB- Effect of growth_hormone on polynucleotide phosphorylase activity in a primary monolayer culture of rat hepatocytes -RSB- .
11701096	0	polyols	59,66	Fhit	84,88	polyols	Fhit	CHEBI:26191	2272	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Di - , _ tri - _ and_tetra-5 ' - O-phosphorothioadenosyl substituted polyols as inhibitors of Fhit : Importance of the alpha-beta bridging oxygen and beta phosphorus replacement .
14621974	0	polyols	10,17	lysozyme	93,101	polyols	lysozyme	CHEBI:26191	4069	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of polyols on the conformational stability and biological activity of a model protein lysozyme .
9477373	0	polyols	15,22	ryanodine_receptor	34,52	polyols	ryanodine receptor	CHEBI:26191	6261	Chemical	Gene	START_ENTITY|nmod|isoforms isoforms|compound|END_ENTITY	Stimulation by polyols of the two ryanodine_receptor isoforms of frog skeletal muscle .
20731121	0	polyoxidonium	14,27	IL-1_beta	31,40	polyoxidonium	IL-1 beta	MESH:C540909	3553	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|production production|amod|END_ENTITY	-LSB- Influence of polyoxidonium on IL-1_beta , TNF-alpha and IL-6 production by mononuclears and monocytes under the dexamethasone effect -RSB- .
7356845	0	polyoxyethylated_cholesterol	123,151	low_density_lipoprotein_receptor	78,110	polyoxyethylated cholesterol	low density lipoprotein receptor	MESH:C023044	3949	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Suppression of synthesis and esterification of cholesterol and stimulation of low_density_lipoprotein_receptor activity by polyoxyethylated_cholesterol in cultured human fibroblasts .
12648397	0	polyphennols	16,28	hepatic_lipase	32,46	polyphennols	hepatic lipase	null	100008678(Tax:9986)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	-LSB- Effects of tea polyphennols on hepatic_lipase activity in rabbits with fatty_liver -RSB- .
19839322	0	polyphenol	22,32	PPO	42,45	polyphenol	PPO	CHEBI:26195	5498	Chemical	Gene	oxidase|amod|START_ENTITY oxidase|appos|END_ENTITY	-LSB- Spectral analysis of polyphenol oxidase -LRB- PPO -RRB- and lipoxygenase -LRB- LOX -RRB- treated by pulsed electric field -RSB- .
22864385	0	polyphenol	21,31	PPO	41,44	polyphenol	PPO	CHEBI:26195	543131(Tax:4565)	Chemical	Gene	oxidase|amod|START_ENTITY oxidase|appos|END_ENTITY	Inheritance of grain polyphenol oxidase -LRB- PPO -RRB- activity in multiple wheat -LRB- Triticum_aestivum_L . -RRB-
23400843	1	polyphenol	52,62	PPO	72,75	polyphenol	PPO	CHEBI:26195	5498	Chemical	Gene	oxidase|amod|START_ENTITY oxidase|appos|END_ENTITY	contains polyphenol oxidase -LRB- PPO -RRB- and PPO substrates that can reduce post-harvest proteolysis .
17620095	0	polyphenol	10,20	caspase_14	29,39	polyphenol	caspase 14	CHEBI:26195	12365(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Green tea polyphenol induces caspase_14 in epidermal keratinocytes via MAPK pathways and reduces psoriasiform_lesions in the flaky skin mouse model .
25123494	0	polyphenol	88,98	pasta	132,137	polyphenol	pasta	CHEBI:26195	50651	Chemical	Gene	content|amod|START_ENTITY content|nmod|END_ENTITY	The effect of hazelnut roasted skin from different cultivars on the quality attributes , polyphenol content and texture of fresh egg pasta .
15870380	0	polyphenol_ellagic_acid	12,35	hOAT1	61,66	polyphenol ellagic acid	hOAT1	null	9356	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	The dietary polyphenol_ellagic_acid is a potent inhibitor of hOAT1 .
21320497	0	polyphenol_epigallocatechin-3-gallate	10,47	TLR2	57,61	polyphenol epigallocatechin-3-gallate	TLR2	null	7097	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|signaling signaling|compound|END_ENTITY	Green tea polyphenol_epigallocatechin-3-gallate inhibits TLR2 signaling induced by peptidoglycan through the polyphenol sensing molecule 67-kDa_laminin_receptor .
22960171	0	polyphenol_epigallocatechin-3-gallate	10,47	TLR4	57,61	polyphenol epigallocatechin-3-gallate	TLR4	null	7099	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Green tea polyphenol_epigallocatechin-3-gallate inhibits TLR4 signaling through the 67-kDa_laminin_receptor on lipopolysaccharide-stimulated dendritic cells .
19445683	0	polyphenol_epigallocatechin-3-gallate	10,47	tumor_necrosis_factor-alpha	110,137	polyphenol epigallocatechin-3-gallate	tumor necrosis factor-alpha	null	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Green tea polyphenol_epigallocatechin-3-gallate inhibits advanced glycation end product-induced expression of tumor_necrosis_factor-alpha and matrix_metalloproteinase-13 in human chondrocytes .
19887561	0	polyphenol_epigallocatechin_gallate	10,45	endothelin-1	54,66	polyphenol epigallocatechin gallate	endothelin-1	null	1906	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|amod|END_ENTITY	Green tea polyphenol_epigallocatechin_gallate reduces endothelin-1 expression and secretion in vascular endothelial cells : roles for AMP-activated protein kinase , Akt , and FOXO1 .
23743621	0	polyphenol_quercetin	57,77	paraoxonase_2	14,27	polyphenol quercetin	paraoxonase 2	null	330260(Tax:10090)	Chemical	Gene	brain|nmod|START_ENTITY END_ENTITY|nmod|brain	Modulation of paraoxonase_2 -LRB- PON2 -RRB- in mouse brain by the polyphenol_quercetin : a mechanism of neuroprotection ?
24610996	0	polyphenolic	37,49	Thrombin	0,8	polyphenolic	Thrombin	null	2147	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Thrombin inhibitory activity of some polyphenolic compounds .
17046132	0	polyphenolic	69,81	glutathione_S-transferases	24,50	polyphenolic	glutathione S-transferases	null	373156	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	The inhibition of human glutathione_S-transferases activity by plant polyphenolic compounds ellagic_acid and curcumin .
17420526	0	polyphenolic_peracetates	106,130	calreticulin	87,99	polyphenolic peracetates	calreticulin	null	811	Chemical	Gene	using|dobj|START_ENTITY END_ENTITY|acl|using	Characterization of protein transacetylase from human placenta as a signaling molecule calreticulin using polyphenolic_peracetates as the acetyl group donors .
12612140	0	polyphenolics	9,22	LDL_receptor	32,44	polyphenolics	LDL receptor	null	3949	Chemical	Gene	increase|nsubj|START_ENTITY increase|dobj|expression expression|amod|END_ENTITY	Red wine polyphenolics increase LDL_receptor expression and activity and suppress the secretion of ApoB100 from human HepG2 cells .
10903418	0	polyphenolics	124,137	ornithine_decarboxylase	76,99	polyphenolics	ornithine decarboxylase	null	18263(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|dobj|END_ENTITY	Inhibition of 12-O-tetradecanoylphorbol-13-acetate -LRB- TPA -RRB- - induced mouse skin ornithine_decarboxylase and protein kinase C by polyphenolics from grapes .
15134489	0	polyphenols	62,73	Bcl-2	29,34	polyphenols	Bcl-2	MESH:D059808	596	Chemical	Gene	proteins|nmod|START_ENTITY proteins|compound|END_ENTITY	Inhibition of anti-apoptotic Bcl-2 family proteins by natural polyphenols : new avenues for cancer chemoprevention and chemotherapy .
24875446	0	polyphenols	31,42	CYP17	48,53	polyphenols	CYP17	MESH:D059808	1586	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|compound|END_ENTITY	Assessment of the potential of polyphenols as a CYP17 inhibitor free of adverse corticosteroid elevation .
19195865	0	polyphenols	10,21	ERK1/2	62,68	polyphenols	ERK1/2	MESH:D059808	5595;5594	Chemical	Gene	START_ENTITY|dobj|expression expression|nmod|END_ENTITY	Green tea polyphenols down-regulate caveolin-1 expression via ERK1/2 and p38MAPK in endothelial cells .
22279672	0	polyphenols	16,27	GSH-Px	47,53	polyphenols	GSH-Px	MESH:D059808	24404(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	-LSB- Effects of tea polyphenols on the activity of GSH-Px and NOS , and the content of MDA and NO in rats fed with high methionine diet -RSB- .
19753602	0	polyphenols	16,27	GSTT2	31,36	polyphenols	GSTT2	MESH:D059808	2953	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Impact of apple polyphenols on GSTT2 gene expression , subsequent protection of DNA and modulation of proliferation using LT97 human colon_adenoma cells .
19753610	0	polyphenols	40,51	GSTT2	0,5	polyphenols	GSTT2	MESH:D059808	2953	Chemical	Gene	induced|nmod|START_ENTITY gene|acl|induced END_ENTITY|appos|gene	GSTT2 , a phase II gene induced by apple polyphenols , protects colon epithelial cells against genotoxic damage .
19082476	0	polyphenols	23,34	HER2	43,47	polyphenols	HER2	MESH:D059808	2064	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|END_ENTITY	Extra-virgin olive oil polyphenols inhibit HER2 -LRB- erbB-2 -RRB- - induced malignant transformation in human breast epithelial cells : relationship between the chemical structures of extra-virgin olive oil secoiridoids and lignans and their inhibitory activities on the tyrosine kinase activity of HER2 .
26357462	0	polyphenols	30,41	HMGR	61,65	polyphenols	HMGR	MESH:D059808	3159	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	Insight into the mechanism of polyphenols on the activity of HMGR by molecular docking .
18317887	0	polyphenols	92,103	NFkappaB	15,23	polyphenols	NFkappaB	MESH:D059808	18033(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Suppression Suppression|nmod|END_ENTITY	Suppression of NFkappaB and its regulated gene products by oral administration of green tea polyphenols in an autochthonous mouse prostate_cancer model .
26926494	0	polyphenols	29,40	Nrf2	0,4	polyphenols	Nrf2	MESH:D059808	4780	Chemical	Gene	target|nmod|START_ENTITY END_ENTITY|nmod|target	Nrf2 as molecular target for polyphenols : A novel therapeutic strategy in diabetic_retinopathy .
23685017	0	polyphenols	14,25	Part_1	82,88	polyphenols	Part 1	MESH:D059808	25859	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|END_ENTITY	Effect of tea polyphenols on the dilational rheology of human_whole_saliva -LRB- HWS -RRB- : Part_1 , HWS characterization .
20450879	0	polyphenols	51,62	SIRT1	14,19	polyphenols	SIRT1	MESH:D059808	23411	Chemical	Gene	role|nmod|START_ENTITY Regulation|dep|role Regulation|nmod|END_ENTITY	Regulation of SIRT1 in cellular functions : role of polyphenols .
22245592	0	polyphenols	109,120	SIRT1	15,20	polyphenols	SIRT1	MESH:D059808	23411	Chemical	Gene	effect|nmod|START_ENTITY Involvement|nmod|effect Involvement|nmod|END_ENTITY	Involvement of SIRT1 in hypoxic down-regulation of c-Myc and b-catenin and hypoxic preconditioning effect of polyphenols .
11237202	0	polyphenols	39,50	TNF-alpha	74,83	polyphenols	TNF-alpha	MESH:D059808	21926(Tax:10090)	Chemical	Gene	START_ENTITY|advcl|inhibition inhibition|nmod|expression expression|amod|END_ENTITY	Mechanisms of cancer prevention by tea polyphenols based on inhibition of TNF-alpha expression .
18495459	0	polyphenols	11,22	TNF-alpha	60,69	polyphenols	TNF-alpha	MESH:D059808	21926(Tax:10090)	Chemical	Gene	attenuate|nsubj|START_ENTITY attenuate|dobj|effects effects|nmod|END_ENTITY	Dried plum polyphenols attenuate the detrimental effects of TNF-alpha on osteoblast function coincident with up-regulation of Runx2 , Osterix and IGF-I .
20540146	0	polyphenols	25,36	TNF-alpha	40,49	polyphenols	TNF-alpha	MESH:D059808	7124	Chemical	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Effects of plant-derived polyphenols on TNF-alpha and nitric_oxide production induced by advanced glycation endproducts .
18354258	0	polyphenols	104,115	VEGF	50,54	polyphenols	VEGF	MESH:D059808	83785(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY expression|dep|effect expression|nmod|END_ENTITY	Angiotensin_II induces the vascular expression of VEGF and MMP-2 in vivo : preventive effect of red wine polyphenols .
9331105	0	polyphenols	99,110	activator_protein_1	37,56	polyphenols	activator protein 1	MESH:D059808	16476(Tax:10090)	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Inhibition of tumor promoter-induced activator_protein_1 activation and cell transformation by tea polyphenols , -LRB- - -RRB- - epigallocatechin_gallate , and theaflavins .
19441816	0	polyphenols	38,49	angiotensin-converting_enzyme	53,82	polyphenols	angiotensin-converting enzyme	MESH:D059808	1636	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effect of Vaccinium myrtillus and its polyphenols on angiotensin-converting_enzyme activity in human endothelial cells .
22253797	0	polyphenols	42,53	apoE	57,61	polyphenols	apoE	MESH:D059808	11816(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Modulation of miRNA expression by dietary polyphenols in apoE deficient mice : a new mechanism of the action of polyphenols .
22245592	0	polyphenols	109,120	b-catenin	61,70	polyphenols	b-catenin	MESH:D059808	1499	Chemical	Gene	effect|nmod|START_ENTITY effect|amod|END_ENTITY	Involvement of SIRT1 in hypoxic down-regulation of c-Myc and b-catenin and hypoxic preconditioning effect of polyphenols .
21047064	0	polyphenols	51,62	b-cyclodextrin	0,14	polyphenols	b-cyclodextrin	MESH:D059808	285440	Chemical	Gene	complexes|nmod|START_ENTITY complexes|compound|END_ENTITY	b-cyclodextrin and caffeine complexes with natural polyphenols from olive and olive oils : NMR , thermodynamic , and molecular modeling studies .
26415702	0	polyphenols	42,53	carbonyl_reductase_1	18,38	polyphenols	carbonyl reductase 1	MESH:D059808	873	Chemical	Gene	modulation|nmod|START_ENTITY modulation|nmod|END_ENTITY	The modulation of carbonyl_reductase_1 by polyphenols .
19195865	0	polyphenols	10,21	caveolin-1	36,46	polyphenols	caveolin-1	MESH:D059808	857	Chemical	Gene	START_ENTITY|dobj|expression expression|amod|END_ENTITY	Green tea polyphenols down-regulate caveolin-1 expression via ERK1/2 and p38MAPK in endothelial cells .
20054477	0	polyphenols	33,44	dihydrofolate_reductase	54,77	polyphenols	dihydrofolate reductase	MESH:D059808	1719	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of natural and synthetic polyphenols to human dihydrofolate_reductase .
10365250	0	polyphenols	96,107	dna_polymerase_alpha	25,45	polyphenols	dna polymerase alpha	MESH:D059808	5422	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of eukaryotic dna_polymerase_alpha by persimmon -LRB- Diospyros kaki -RRB- extract and related polyphenols .
11374875	0	polyphenols	10,21	dopa_decarboxylase	56,74	polyphenols	dopa decarboxylase	MESH:D059808	1644	Chemical	Gene	START_ENTITY|dep|inhibitors inhibitors|nmod|END_ENTITY	Green tea polyphenols : novel irreversible inhibitors of dopa_decarboxylase .
15333638	0	polyphenols	89,100	endothelial_nitric-oxide_synthase	14,47	polyphenols	endothelial nitric-oxide synthase	MESH:D059808	4846	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of endothelial_nitric-oxide_synthase by the p38_MAPK in response to black tea polyphenols .
18813848	0	polyphenols	44,55	fatty_acid_synthase	84,103	polyphenols	fatty acid synthase	MESH:D059808	2194	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Analyzing effects of extra-virgin olive oil polyphenols on breast_cancer-associated fatty_acid_synthase protein expression using reverse-phase protein microarrays .
9374426	0	polyphenols	45,56	glutathione_reductase	14,35	polyphenols	glutathione reductase	MESH:D059808	2936	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of glutathione_reductase by plant polyphenols .
19403032	0	polyphenols	15,26	nuclear_factor_kappa_B	44,66	polyphenols	nuclear factor kappa B	MESH:D059808	81736(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Effect of tea polyphenols on expression of nuclear_factor_kappa_B -RSB- .
15333638	0	polyphenols	89,100	p38_MAPK	55,63	polyphenols	p38 MAPK	MESH:D059808	1432	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of endothelial_nitric-oxide_synthase by the p38_MAPK in response to black tea polyphenols .
11522280	0	polyphenols	8,19	p53	29,32	polyphenols	p53	MESH:D059808	7157	Chemical	Gene	modulate|nsubj|START_ENTITY modulate|dobj|expression expression|compound|END_ENTITY	Do wine polyphenols modulate p53 gene expression in human cancer cell lines ?
15169886	0	polyphenols	8,19	paraoxonase_1	29,42	polyphenols	paraoxonase 1	MESH:D059808	5444	Chemical	Gene	increase|nsubj|START_ENTITY increase|dobj|expression expression|amod|END_ENTITY	Dietary polyphenols increase paraoxonase_1 gene expression by an aryl_hydrocarbon_receptor-dependent mechanism .
19713834	0	polyphenols	10,21	plasminogen_activator_inhibitor-1	30,63	polyphenols	plasminogen activator inhibitor-1	MESH:D059808	281375(Tax:9913)	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|expression expression|amod|END_ENTITY	Green tea polyphenols inhibit plasminogen_activator_inhibitor-1 expression and secretion in endothelial cells .
24028635	0	polyphenols	4,15	renin	66,71	polyphenols	renin	MESH:D059808	5972	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Tea polyphenols as novel and potent inhibitory substances against renin activity .
15541362	0	polyphenols	10,21	ribonuclease_A	39,53	polyphenols	ribonuclease A	MESH:D059808	282340(Tax:9913)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Green tea polyphenols as inhibitors of ribonuclease_A .
10679280	0	polyphenols	10,21	squalene_epoxidase	54,72	polyphenols	squalene epoxidase	MESH:D059808	29230(Tax:10116)	Chemical	Gene	START_ENTITY|dep|inhibitors inhibitors|nmod|END_ENTITY	Green tea polyphenols : novel and potent inhibitors of squalene_epoxidase .
11806426	0	polyphenols	26,37	tea	22,25	polyphenols	tea	MESH:D059808	11988(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|END_ENTITY	Protective effects of tea polyphenols on mild hypobaric_hypoxia induced pulmonary_free_radical_metabolic_disorder in mice .
21452375	0	polyphenols	23,34	tea	19,22	polyphenols	tea	MESH:D059808	11988(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	Protective role of tea polyphenols in combination against radiation-induced haematopoietic and biochemical alterations in mice .
14704129	0	polyphenols	25,36	transforming_growth_factor-beta1	40,72	polyphenols	transforming growth factor-beta1	MESH:D059808	59086(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Inhibitory effect of tea polyphenols on transforming_growth_factor-beta1 expression in rat with cyclosporine_A-induced chronic nephrotoxicity .
16091006	0	polyphenols	10,21	urokinase_plasminogen_activator	44,75	polyphenols	urokinase plasminogen activator	MESH:D059808	5328	Chemical	Gene	modulate|nsubj|START_ENTITY modulate|dobj|secretion secretion|nmod|END_ENTITY	Green tea polyphenols modulate secretion of urokinase_plasminogen_activator -LRB- uPA -RRB- and inhibit invasive behavior of breast_cancer cells .
20952447	0	polyphenols_fisetin	22,41	ERK	0,3	polyphenols fisetin	ERK	null	24338(Tax:10116)	Chemical	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	ERK activation by the polyphenols_fisetin and resveratrol provides neuroprotection in multiple models of Huntington 's _ disease .
10208869	0	polyphosphate	33,46	Spt7p	15,20	polyphosphate	Spt7p	CHEBI:16838	852373(Tax:4932)	Chemical	Gene	START_ENTITY|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of Spt7p in vacuolar polyphosphate level of Saccharomyces_cerevisiae .
20060443	0	polyphosphate	21,34	bone_sialoprotein	38,55	polyphosphate	bone sialoprotein	CHEBI:16838	24477(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|amod|END_ENTITY	Effects of inorganic polyphosphate on bone_sialoprotein gene expression .
10961683	0	polyphosphates	55,69	Ca2	76,79	polyphosphates	Ca2	MESH:D011122	760	Chemical	Gene	START_ENTITY|nmod|+ +|amod|END_ENTITY	Effect of ethanol on structural transitions of DNA and polyphosphates under Ca2 + ions action in mixed solutions .
1334440	0	polyphosphoinositide	50,70	TGF-alpha	15,24	polyphosphoinositide	TGF-alpha	MESH:D018129	7039	Chemical	Gene	metabolism|amod|START_ENTITY effects|nmod|metabolism effects|nmod|END_ENTITY	The effects of TGF-alpha and 17_beta-estradiol on polyphosphoinositide metabolism in MCF-7 breast_cancer cells .
2154447	0	polyphosphoinositide	46,66	Thrombin	0,8	polyphosphoinositide	Thrombin	MESH:D018129	2147	Chemical	Gene	production|nmod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Thrombin stimulates the production of a novel polyphosphoinositide in human platelets .
6317349	0	polyphosphoinositide	35,55	angiotensin-II	17,31	polyphosphoinositide	angiotensin-II	MESH:D018129	24179(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY effects|nmod|metabolism effects|nmod|END_ENTITY	Rapid effects of angiotensin-II on polyphosphoinositide metabolism in the rat adrenal glomerulosa .
11053443	0	polyproline	15,26	Mdm2	62,66	polyproline	Mdm2	MESH:C011083	4193	Chemical	Gene	domain|amod|START_ENTITY role|nmod|domain role|nmod|END_ENTITY	A role for the polyproline domain of p53 in its regulation by Mdm2 .
11053443	0	polyproline	15,26	p53	37,40	polyproline	p53	MESH:C011083	7157	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	A role for the polyproline domain of p53 in its regulation by Mdm2 .
12459898	0	polypyridine	51,63	glucose_oxidase	16,31	polypyridine	glucose oxidase	null	54363	Chemical	Gene	START_ENTITY|nsubj|Interactions Interactions|nmod|END_ENTITY	Interactions of glucose_oxidase with various metal polypyridine complexes as mediators of glucose oxidation .
17539608	0	polypyridine_carboxylate	61,85	Gd3	46,49	polypyridine carboxylate	Gd3	null	117189	Chemical	Gene	complexes|compound|START_ENTITY complexes|amod|END_ENTITY	Multiple-frequency EPR spectra of two aqueous Gd3 + polyamino polypyridine_carboxylate complexes : a study of high field effects .
25014769	0	polypyrimidine	11,25	DmPTB	49,54	polypyrimidine	DmPTB	null	48571(Tax:7227)	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Drosophila polypyrimidine tract-binding protein -LRB- DmPTB -RRB- regulates dorso-ventral patterning genes in embryos .
12359957	0	polypyrimidine	73,87	PTB	111,114	polypyrimidine	PTB	null	29497(Tax:10116)	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Hypoxia may increase rat insulin mRNA levels by promoting binding of the polypyrimidine tract-binding protein -LRB- PTB -RRB- to the pyrimidine-rich insulin mRNA 3 ' - untranslated region .
14659561	0	polypyrimidine	29,43	PTB	67,70	polypyrimidine	PTB	null	19205(Tax:10090)	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	A 25 kDa cleavage product of polypyrimidine tract binding protein -LRB- PTB -RRB- present in mouse tissues prevents PTB binding to the 5 ' untranslated region and inhibits translation of hepatitis_A_virus RNA .
15228089	0	polypyrimidine	31,45	PTB	69,72	polypyrimidine	PTB	null	29497(Tax:10116)	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Glucose-induced binding of the polypyrimidine tract-binding protein -LRB- PTB -RRB- to the 3 ' - untranslated region of the insulin mRNA -LRB- ins-PRS -RRB- is inhibited by rapamycin .
16102869	0	polypyrimidine	4,18	PTB	42,45	polypyrimidine	PTB	null	5725	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	The polypyrimidine tract-binding protein -LRB- PTB -RRB- is required for efficient replication of hepatitis_C_virus _ -LRB- HCV -RRB- RNA .
16950790	0	polypyrimidine	4,18	PTB	42,45	polypyrimidine	PTB	null	5725	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	The polypyrimidine tract-binding protein -LRB- PTB -RRB- is involved in the post-transcriptional regulation of human inducible nitric_oxide synthase expression .
19450550	4	polypyrimidine	551,565	PTB	589,592	polypyrimidine	PTB	null	5725	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Our study identified polypyrimidine tract-binding protein -LRB- PTB -RRB- as a novel interacting partner of DENV NS4A protein .
8548657	0	polypyrimidine	21,35	PTB	59,62	polypyrimidine	PTB	null	5725	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Direct evidence that polypyrimidine tract binding protein -LRB- PTB -RRB- is essential for internal initiation of translation of encephalomyocarditis_virus RNA .
19122103	0	polypyrimidine	2,16	RBP50	48,53	polypyrimidine	RBP50	null	10540	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	A polypyrimidine tract binding protein , pumpkin RBP50 , forms the basis of a phloem-mobile ribonucleoprotein complex .
7539809	0	polypyrimidine	91,105	hnRNP_I	129,136	polypyrimidine	hnRNP I	null	5725	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	A perinucleolar compartment contains several RNA polymerase III transcripts as well as the polypyrimidine tract-binding protein , hnRNP_I .
22158871	0	polysialic_acid	78,93	FGF2	48,52	polysialic acid	FGF2	MESH:C021319	14173(Tax:10090)	Chemical	Gene	growth|nmod|START_ENTITY regulation|dep|growth regulation|nmod|fibroblast_growth_factor_2 fibroblast_growth_factor_2|appos|END_ENTITY	Novel regulation of fibroblast_growth_factor_2 -LRB- FGF2 -RRB- - mediated cell growth by polysialic_acid .
26163659	0	polysialic_acid	22,37	FGF2	65,69	polysialic acid	FGF2	MESH:C021319	2247	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Protective effects of polysialic_acid on proteolytic cleavage of FGF2 and proBDNF/BDNF .
1541638	0	polysialic_acid	39,54	NCAM	66,70	polysialic acid	NCAM	MESH:C021319	4684	Chemical	Gene	content|amod|START_ENTITY content|nmod|END_ENTITY	Intercellular space is affected by the polysialic_acid content of NCAM .
9516473	0	polysialic_acid	53,68	PST	90,93	polysialic acid	PST	MESH:C021319	20452(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|gene gene|amod|synthase synthase|dep|END_ENTITY	Genomic structure and promoter activity of the mouse polysialic_acid synthase -LRB- mST8Sia_IV / PST -RRB- gene .
18045870	0	polysialic_acid	62,77	ST8SiaII	37,45	polysialic acid	ST8SiaII	MESH:C021319	20450(Tax:10090)	Chemical	Gene	synthesis|amod|START_ENTITY END_ENTITY|nmod|synthesis	Impact of the polysialyltransferases ST8SiaII and ST8SiaIV on polysialic_acid synthesis during postnatal mouse brain development .
20206239	0	polysialic_acid	72,87	ST8SiaII	47,55	polysialic acid	ST8SiaII	MESH:C021319	20450(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Divergent impact of the polysialyltransferases ST8SiaII and ST8SiaIV on polysialic_acid expression in immature neurons and interneurons of the adult cerebral cortex .
9498575	0	polysialic_acid	4,19	ST8Sia_II	37,46	polysialic acid	ST8Sia II	MESH:C021319	20450(Tax:10090)	Chemical	Gene	synthases|amod|START_ENTITY synthases|appos|END_ENTITY	Two polysialic_acid synthases , mouse ST8Sia_II and IV , synthesize different degrees of polysialic_acids on different substrate glycoproteins in mouse_neuroblastoma Neuro2a cells .
8939967	0	polysialic_acid	53,68	mST8Sia_II	84,94	polysialic acid	mST8Sia II	MESH:C021319	20450(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|gene gene|appos|END_ENTITY	Genomic structure and promoter activity of the mouse polysialic_acid synthase gene -LRB- mST8Sia_II -RRB- .
11133150	0	polysialic_acid	4,19	neural_cell_adhesion_molecule	34,63	polysialic acid	neural cell adhesion molecule	MESH:C021319	428253(Tax:9031)	Chemical	Gene	moiety|amod|START_ENTITY moiety|nmod|END_ENTITY	The polysialic_acid moiety of the neural_cell_adhesion_molecule is involved in intraretinal guidance of retinal ganglion cell axons .
12765789	0	polysialic_acid	41,56	neural_cell_adhesion_molecule	74,103	polysialic acid	neural cell adhesion molecule	MESH:C021319	4684	Chemical	Gene	synthesis|amod|START_ENTITY synthesis|nmod|END_ENTITY	Polysialyltransferases : major players in polysialic_acid synthesis on the neural_cell_adhesion_molecule .
8843031	0	polysialic_acid	4,19	neural_cell_adhesion_molecule	40,69	polysialic acid	neural cell adhesion molecule	MESH:C021319	24586(Tax:10116)	Chemical	Gene	modification|amod|START_ENTITY modification|nmod|END_ENTITY	The polysialic_acid modification of the neural_cell_adhesion_molecule is involved in spatial learning and hippocampal long-term potentiation .
9765230	0	polysialic_acid	11,26	neural_cell_adhesion_molecule	30,59	polysialic acid	neural cell adhesion molecule	MESH:C021319	17967(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|binding binding|amod|END_ENTITY	A role for polysialic_acid in neural_cell_adhesion_molecule heterophilic binding to proteoglycans .
6671346	0	polystyrene	28,39	CEA	7,10	polystyrene	CEA	MESH:D011137	1084	Chemical	Gene	-RSB-|compound|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- Serum CEA determination by polystyrene bead -RSB- .
8573291	0	polystyrene	46,57	beta_2_glycoprotein_I	11,32	polystyrene	beta 2 glycoprotein I	MESH:D011137	350	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of beta_2_glycoprotein_I to activated polystyrene and its recognition by human IgG autoantibodies .
2119386	0	polystyrene_sulphonate	78,100	basic_fibroblast_growth_factor	44,74	polystyrene sulphonate	basic fibroblast growth factor	null	281161(Tax:9913)	Chemical	Gene	resins|amod|START_ENTITY END_ENTITY|nmod|resins	High-performance affinity chromatography of basic_fibroblast_growth_factor on polystyrene_sulphonate resins modified with serine .
24607879	0	polyunsaturated_Fatty_Acid	50,76	neurotrophin_4	20,34	polyunsaturated Fatty Acid	neurotrophin 4	CHEBI:26208	4909	Chemical	Gene	START_ENTITY|nsubj|Association Association|nmod|END_ENTITY	Association between neurotrophin_4 and long-chain polyunsaturated_Fatty_Acid levels in mid-trimester amniotic fluid .
12683809	0	polyunsaturated_docosohexaenoic_acid	49,85	Rhodopsin	0,9	polyunsaturated docosohexaenoic acid	Rhodopsin	null	6010	Chemical	Gene	exhibits|nmod|START_ENTITY exhibits|nsubj|END_ENTITY	Rhodopsin exhibits a preference for solvation by polyunsaturated_docosohexaenoic_acid .
17510185	0	polyunsaturated_fatty_acid	41,67	Protein_kinase_A	0,16	polyunsaturated fatty acid	Protein kinase A	CHEBI:26208	25636(Tax:10116)	Chemical	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	Protein_kinase_A is activated by the n-3 polyunsaturated_fatty_acid eicosapentaenoic_acid in rat ventricular muscle .
16936261	0	polyunsaturated_fatty_acid	137,163	peroxisome_proliferator-activated_receptor-alpha	80,128	polyunsaturated fatty acid	peroxisome proliferator-activated receptor-alpha	CHEBI:26208	25747(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY treatment|compound|END_ENTITY	A model of insulin resistance and nonalcoholic_steatohepatitis in rats : role of peroxisome_proliferator-activated_receptor-alpha and n-3 polyunsaturated_fatty_acid treatment on liver_injury .
16391323	0	polyunsaturated_fatty_acids	44,71	ADRP	14,18	polyunsaturated fatty acids	ADRP	MESH:D005231	123	Chemical	Gene	expression|nmod|START_ENTITY expression|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of ADRP expression by long-chain polyunsaturated_fatty_acids in BeWo cells , a human placental_choriocarcinoma cell line .
17179391	0	polyunsaturated_fatty_acids	15,42	Akt	73,76	polyunsaturated fatty acids	Akt	MESH:D005231	24185(Tax:10116)	Chemical	Gene	START_ENTITY|dep|phosphorylation phosphorylation|nmod|END_ENTITY	Long-chain n-3 polyunsaturated_fatty_acids dissociate phosphorylation of Akt from phosphatidylinositol 3 ' - kinase activity in rats .
22943296	0	polyunsaturated_fatty_acids	20,47	BDNF	114,118	polyunsaturated fatty acids	BDNF	MESH:D005231	627	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Agonistic effect of polyunsaturated_fatty_acids -LRB- PUFAs -RRB- and its metabolites on brain-derived_neurotrophic_factor -LRB- BDNF -RRB- through molecular docking simulation .
12064337	0	polyunsaturated_fatty_acids	36,63	BRCA1	67,72	polyunsaturated fatty acids	BRCA1	MESH:D005231	672	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|compound|END_ENTITY	Differential effects of n-3 and n-6 polyunsaturated_fatty_acids on BRCA1 and BRCA2 gene expression in breast cell lines .
22113248	0	polyunsaturated_fatty_acids	25,52	C-reactive_protein	58,76	polyunsaturated fatty acids	C-reactive protein	MESH:D005231	1401	Chemical	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of serum n-3 polyunsaturated_fatty_acids with C-reactive_protein in men .
24052576	0	polyunsaturated_fatty_acids	38,65	HER2	18,22	polyunsaturated fatty acids	HER2	MESH:D005231	13866(Tax:10090)	Chemical	Gene	pathway|nmod|START_ENTITY pathway|compound|END_ENTITY	Inhibition of the HER2 pathway by n-3 polyunsaturated_fatty_acids prevents breast_cancer in fat-1 transgenic_mice .
20187917	0	polyunsaturated_fatty_acids	11,38	IL-4	118,122	polyunsaturated fatty acids	IL-4	MESH:D005231	403785(Tax:9615)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of polyunsaturated_fatty_acids on isolated canine peripheral blood mononuclear cells and cytokine expression -LRB- IL-4 , IFN-gamma , TGF-beta -RRB- in healthy and atopic dogs .
15219460	0	polyunsaturated_fatty_acids	10,37	L-selectin	65,75	polyunsaturated fatty acids	L-selectin	MESH:D005231	6402	Chemical	Gene	Impact|nmod|START_ENTITY Impact|nmod|END_ENTITY	Impact of polyunsaturated_fatty_acids on cytoskeletal linkage of L-selectin .
17624613	0	polyunsaturated_fatty_acids	21,48	MMP-9	52,57	polyunsaturated fatty acids	MMP-9	MESH:D005231	4318	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	Inhibitory effect of polyunsaturated_fatty_acids on MMP-9 release from microglial cells -- implications for complementary multiple_sclerosis treatment .
21270364	0	polyunsaturated_fatty_acids	123,150	Methylenetetrahydrofolate_reductase	0,35	polyunsaturated fatty acids	Methylenetetrahydrofolate reductase	MESH:D005231	4524	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubj|variants variants|amod|END_ENTITY	Methylenetetrahydrofolate_reductase variants associated with hypertension and cardiovascular_disease interact with dietary polyunsaturated_fatty_acids to modulate plasma homocysteine in puerto rican adults .
8898299	0	polyunsaturated_fatty_acids	44,71	P450	86,90	polyunsaturated fatty acids	P450	MESH:D005231	1555	Chemical	Gene	hydroxylation|nmod|START_ENTITY hydroxylation|nmod|END_ENTITY	Bisallylic hydroxylation and epoxidation of polyunsaturated_fatty_acids by cytochrome P450 .
16940242	0	polyunsaturated_fatty_acids	71,98	PPAR-gamma2	0,11	polyunsaturated fatty acids	PPAR-gamma2	MESH:D005231	5468	Chemical	Gene	START_ENTITY|nsubj|resistance resistance|compound|END_ENTITY	PPAR-gamma2 Pro12Ala variant , insulin resistance and plasma long-chain polyunsaturated_fatty_acids in childhood_obesity .
15845283	0	polyunsaturated_fatty_acids	22,49	PUFA	51,55	polyunsaturated fatty acids	PUFA	MESH:D005231	100531402	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of dietary polyunsaturated_fatty_acids -LRB- PUFA -RRB- on infection with the nematodes Ostertagia ostertagi and Cooperia_oncophora in calves .
18077200	0	polyunsaturated_fatty_acids	11,38	RANK-L	60,66	polyunsaturated fatty acids	RANK-L	MESH:D005231	21943(Tax:10090)	Chemical	Gene	alter|nsubj|START_ENTITY alter|dobj|expression expression|compound|END_ENTITY	Long chain polyunsaturated_fatty_acids alter membrane-bound RANK-L expression and osteoprotegerin secretion by MC3T3-E1 osteoblast-like cells .
23305113	0	polyunsaturated_fatty_acids	94,121	SIRT1	49,54	polyunsaturated fatty acids	SIRT1	MESH:D005231	23411	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	The combined effects of genetic variation in the SIRT1 gene and dietary intake of n-3 and n-6 polyunsaturated_fatty_acids on serum LDL-C and HDL-C levels : a population based study .
16901908	0	polyunsaturated_fatty_acids	55,82	TRP_gamma	42,51	polyunsaturated fatty acids	TRP gamma	MESH:D005231	34991(Tax:7227)	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Receptor-induced activation of Drosophila TRP_gamma by polyunsaturated_fatty_acids .
24356795	0	polyunsaturated_fatty_acids	15,42	adiponectin	66,77	polyunsaturated fatty acids	adiponectin	MESH:D005231	9370	Chemical	Gene	START_ENTITY|acl|circulating circulating|dobj|END_ENTITY	Effects of n-3 polyunsaturated_fatty_acids -LRB- PUFAs -RRB- on circulating adiponectin and leptin in subjects with type_2_diabetes_mellitus .
1720022	0	polyunsaturated_fatty_acids	57,84	alpha-fetoprotein	10,27	polyunsaturated fatty acids	alpha-fetoprotein	MESH:D005231	24177(Tax:10116)	Chemical	Gene	uptake|nmod|START_ENTITY Effect|nmod|uptake Effect|nmod|END_ENTITY	Effect of alpha-fetoprotein and albumin on the uptake of polyunsaturated_fatty_acids by rat hepatoma cells and fetal rat hepatocytes .
22475809	0	polyunsaturated_fatty_acids	12,39	angiotensinogen	72,87	polyunsaturated fatty acids	angiotensinogen	MESH:D005231	183	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	n-3 and n-6 polyunsaturated_fatty_acids differentially regulate adipose angiotensinogen and other inflammatory adipokines in part via NF-kB-dependent mechanisms .
9680670	0	polyunsaturated_fatty_acids	42,69	bradykinin	132,142	polyunsaturated fatty acids	bradykinin	MESH:D005231	3827	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of anti-atherosclerotic diet with polyunsaturated_fatty_acids omega-3 from linseed oil on dynamics of natural antibodies to bradykinin and angiotensin_II in blood serum of patients with cardiovascular_diseases -RSB- .
23911220	0	polyunsaturated_fatty_acids	98,125	brain-derived_neurotrophic_factor	38,71	polyunsaturated fatty acids	brain-derived neurotrophic factor	MESH:D005231	627	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|amod|END_ENTITY	Autism as a disorder_of_deficiency of brain-derived_neurotrophic_factor and altered metabolism of polyunsaturated_fatty_acids .
9635881	0	polyunsaturated_fatty_acids	34,61	cyclooxygenase_1_and_2	83,105	polyunsaturated fatty acids	cyclooxygenase 1 and 2	MESH:D005231	24693;29527	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	The effect of dietary n-3 and n-6 polyunsaturated_fatty_acids on the expression of cyclooxygenase_1_and_2 and levels of p21ras in rat mammary glands .
16517146	0	polyunsaturated_fatty_acids	12,39	cytochrome_P-450_2B1	54,74	polyunsaturated fatty acids	cytochrome P-450 2B1	MESH:D005231	24300(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	n-6 and n-3 polyunsaturated_fatty_acids down-regulate cytochrome_P-450_2B1 gene expression induced by phenobarbital in primary rat hepatocytes .
2212394	0	polyunsaturated_fatty_acids	39,66	fibrinogen	77,87	polyunsaturated fatty acids	fibrinogen	MESH:D005231	2244	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	The comparative effects of n-3 and n-6 polyunsaturated_fatty_acids on plasma fibrinogen levels : a controlled clinical trial in hypertriglyceridemic subjects .
21530211	0	polyunsaturated_fatty_acids	18,45	leukotriene_B	49,62	polyunsaturated fatty acids	leukotriene B	MESH:D005231	4050	Chemical	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	The effect of n-3 polyunsaturated_fatty_acids on leukotriene_B and leukotriene_B production from stimulated neutrophil granulocytes in patients with chronic_kidney_disease .
24096482	0	polyunsaturated_fatty_acids	25,52	mTORC1/2	0,8	polyunsaturated fatty acids	mTORC1/2	MESH:D005231	74343;382056	Chemical	Gene	targeted|nmod|START_ENTITY targeted|nsubj|END_ENTITY	mTORC1/2 targeted by n-3 polyunsaturated_fatty_acids in the prevention of mammary_tumorigenesis and tumor progression .
9227328	0	polyunsaturated_fatty_acids	63,90	neutral_sphingomyelinase	14,38	polyunsaturated fatty acids	neutral sphingomyelinase	MESH:D005231	6610	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of neutral_sphingomyelinase in human neutrophils by polyunsaturated_fatty_acids .
9514051	0	polyunsaturated_fatty_acids	19,46	nm-23	68,73	polyunsaturated fatty acids	nm-23	MESH:D005231	4830	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|nmod|END_ENTITY	The effects of n-6 polyunsaturated_fatty_acids on the expression of nm-23 in human cancer cells .
18158339	0	polyunsaturated_fatty_acids	12,39	renin	123,128	polyunsaturated fatty acids	renin	MESH:D005231	5972	Chemical	Gene	improve|nsubj|START_ENTITY improve|nmod|model model|nmod|hypertension hypertension|compound|END_ENTITY	Dietary n-3 polyunsaturated_fatty_acids and direct renin inhibition improve electrical remodeling in a model of high human renin hypertension .
6397528	0	polyunsaturated_fatty_acids	32,59	renin	63,68	polyunsaturated fatty acids	renin	MESH:D005231	24715(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	An inhibitory effect of dietary polyunsaturated_fatty_acids on renin secretion in the isolated perfused rat kidney .
26828067	0	polyunsaturated_fatty_acids	48,75	secreted_phospholipase_A2	8,33	polyunsaturated fatty acids	secreted phospholipase A2	MESH:D005231	18780(Tax:10090)	Chemical	Gene	releases|dobj|START_ENTITY releases|nsubj|END_ENTITY	Group X secreted_phospholipase_A2 releases -3 polyunsaturated_fatty_acids , suppresses colitis and promotes sperm fertility .
10484602	0	polyunsaturated_fatty_acids	41,68	stearoyl-CoA_desaturase	14,37	polyunsaturated fatty acids	stearoyl-CoA desaturase	MESH:D005231	20249(Tax:10090)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of stearoyl-CoA_desaturase by polyunsaturated_fatty_acids and cholesterol .
11414710	0	polyunsaturated_fatty_acids	171,198	stearoyl-CoA_desaturase	42,65	polyunsaturated fatty acids	stearoyl-CoA desaturase	MESH:D005231	6319	Chemical	Gene	activation|nmod|START_ENTITY Cloning|dep|activation Cloning|nmod|promoter promoter|amod|END_ENTITY	Cloning and characterization of the human stearoyl-CoA_desaturase gene promoter : transcriptional activation by sterol_regulatory_element_binding_protein and repression by polyunsaturated_fatty_acids and cholesterol .
8939925	0	polyunsaturated_fatty_acids	58,85	stearoyl-CoA_desaturase	14,37	polyunsaturated fatty acids	stearoyl-CoA desaturase	MESH:D005231	6319	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|stability stability|compound|END_ENTITY	Regulation of stearoyl-CoA_desaturase 1 mRNA stability by polyunsaturated_fatty_acids in 3T3-L1 adipocytes .
11414710	0	polyunsaturated_fatty_acids	171,198	sterol_regulatory_element_binding_protein	111,152	polyunsaturated fatty acids	sterol regulatory element binding protein	MESH:D005231	7555	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Cloning and characterization of the human stearoyl-CoA_desaturase gene promoter : transcriptional activation by sterol_regulatory_element_binding_protein and repression by polyunsaturated_fatty_acids and cholesterol .
18450755	0	polyunsaturated_fatty_acids	71,98	syndecan_1	35,45	polyunsaturated fatty acids	syndecan 1	MESH:D005231	6382	Chemical	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	In vivo and in vitro regulation of syndecan_1 in prostate cells by n-3 polyunsaturated_fatty_acids .
8701396	0	polyunsaturated_fatty_acids	76,103	tissue_factor_pathway_inhibitor	27,58	polyunsaturated fatty acids	tissue factor pathway inhibitor	MESH:D005231	7035	Chemical	Gene	levels|nmod|START_ENTITY levels|nmod|END_ENTITY	Increased plasma levels of tissue_factor_pathway_inhibitor -LRB- TFPI -RRB- after n-3 polyunsaturated_fatty_acids supplementation in patients with chronic atherosclerotic_disease .
18680379	0	polyunsaturated_lysophosphatidylcholines	39,79	lipoxygenase	14,26	polyunsaturated lysophosphatidylcholines	lipoxygenase	null	547836(Tax:3847)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|activity activity|amod|END_ENTITY	Regulation of lipoxygenase activity by polyunsaturated_lysophosphatidylcholines or their oxygenation derivatives .
22154859	0	polyurethane	45,57	IFN-y	78,83	polyurethane	IFN-y	MESH:D011140	3458	Chemical	Gene	mediated|nmod|START_ENTITY mediated|nmod|END_ENTITY	Cell death in HeLa mediated by thermoplastic polyurethane with co-immobilized IFN-y plus TNF-a .
21347565	0	polyurethane	57,69	IGF-1	22,27	polyurethane	IGF-1	MESH:D011140	3479	Chemical	Gene	release|nmod|START_ENTITY release|nmod|END_ENTITY	Controlled release of IGF-1 and HGF from a biodegradable polyurethane scaffold .
826460	0	polyurethane	89,101	phospholipase-A	45,60	polyurethane	phospholipase-A	MESH:D011140	57110	Chemical	Gene	Stimulation|nmod|START_ENTITY Stimulation|nmod|END_ENTITY	Stimulation of human platelet_aggregation by phospholipase-A and a saline `` extract '' of a polyurethane .
17032588	0	polyvinyl_alcohol	53,70	albumin	89,96	polyvinyl alcohol	albumin	MESH:D011142	213	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of amino_acid supplements and replacement of polyvinyl_alcohol with bovine serum albumin in porcine zygote medium .
12781474	0	ponazuril	27,36	interferon-gamma	112,128	ponazuril	interferon-gamma	MESH:C415002	15978(Tax:10090)	Chemical	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Effect of a single dose of ponazuril on neural_infection and clinical disease in Sarcocystis neurona-challenged interferon-gamma knockout mice .
18057724	0	poncirin	66,74	COX-2	32,37	poncirin	COX-2	MESH:C119641	19225(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Inhibition of LPS-induced iNOS , COX-2 and cytokines expression by poncirin through the NF-kappaB inactivation in RAW 264.7 macrophage cells .
18057724	0	poncirin	66,74	iNOS	26,30	poncirin	iNOS	MESH:C119641	18126(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY END_ENTITY|appos|expression	Inhibition of LPS-induced iNOS , COX-2 and cytokines expression by poncirin through the NF-kappaB inactivation in RAW 264.7 macrophage cells .
25498336	0	porcine	11,18	GPIHBP1	19,26	porcine	GPIHBP1	null	338328	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Cloning of porcine GPIHBP1 gene and its tissue expression pattern and genetic effect on adipose traits .
24587102	0	porphodimethene	2,17	uroporphyrinogen_decarboxylase	40,70	porphodimethene	uroporphyrinogen decarboxylase	null	7389	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|nmod|END_ENTITY	A porphodimethene chemical inhibitor of uroporphyrinogen_decarboxylase .
19202270	0	porphyran	28,37	apolipoprotein_B100	46,65	porphyran	apolipoprotein B100	MESH:C038549	338	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|secretion secretion|amod|END_ENTITY	The sulfated polysaccharide porphyran reduces apolipoprotein_B100 secretion and lipid synthesis in HepG2 cells .
21118089	0	porphyrin	31,40	ABCG2	12,17	porphyrin	ABCG2	CHEBI:8337	9429	Chemical	Gene	metabolism|amod|START_ENTITY role|nmod|metabolism role|nmod|END_ENTITY	The role of ABCG2 and ABCB6 in porphyrin metabolism and cell survival .
6267055	0	porphyrin	39,48	Growth_hormone	0,14	porphyrin	Growth hormone	CHEBI:8337	2688	Chemical	Gene	formation|compound|START_ENTITY stimulates|dobj|formation stimulates|nsubj|END_ENTITY	Growth_hormone stimulates drug-induced porphyrin formation in liver cells maintained in a serum-free medium .
18326586	0	porphyrin	26,35	PUG1	8,12	porphyrin	PUG1	CHEBI:8337	856934(Tax:4932)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of PUG1 in inducible porphyrin and heme transport in Saccharomyces_cerevisiae .
22046489	0	porphyrin	15,24	WNT1	54,58	porphyrin	WNT1	CHEBI:8337	7471	Chemical	Gene	START_ENTITY|dobj|expression expression|compound|END_ENTITY	The gold -LRB- III -RRB- porphyrin complex , gold-2a , suppresses WNT1 expression in breast_cancer cells by enhancing the promoter association of YY1 .
11959466	0	porphyrin	41,50	acetylcholinesterase	82,102	porphyrin	acetylcholinesterase	CHEBI:8337	43	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of monosulfonate tetraphenyl porphyrin , a competitive inhibitor , with acetylcholinesterase .
6272840	0	porphyrin	22,31	cytochrome_c	45,57	porphyrin	cytochrome c	CHEBI:8337	54205	Chemical	Gene	structure|compound|START_ENTITY structure|nmod|END_ENTITY	Protein influences on porphyrin structure in cytochrome_c : evidence from Raman difference spectroscopy .
8738813	0	porphyrin	47,56	erythropoietin	29,43	porphyrin	erythropoietin	CHEBI:8337	2056	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	Effects of recombinant human erythropoietin on porphyrin metabolism in uremic patients on hemodialysis .
2804139	0	porphyrins	20,30	ferrochelatase	64,78	porphyrins	ferrochelatase	MESH:D011166	14151(Tax:10090)	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of free porphyrins and metalloporphyrins with mouse ferrochelatase .
6497856	0	porphyrins	28,38	ferrochelatase	75,89	porphyrins	ferrochelatase	MESH:D011166	361338(Tax:10116)	Chemical	Gene	interaction|nmod|START_ENTITY used|nsubj|interaction used|nmod|END_ENTITY	Differential interaction of porphyrins used in photoradiation therapy with ferrochelatase .
19560444	0	porphyrins	15,25	organic_anion_transporting_polypeptide_1B1	37,79	porphyrins	organic anion transporting polypeptide 1B1	MESH:D011166	10599	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of porphyrins with human organic_anion_transporting_polypeptide_1B1 .
8887988	0	postdexamethasone	48,65	beta-endorphin	66,80	postdexamethasone	beta-endorphin	null	5443	Chemical	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Stimulatory effects of L-5-hydroxytryptophan on postdexamethasone beta-endorphin levels in major_depression .
3135847	1	postdexamethasone	129,146	prolactin	147,156	postdexamethasone	prolactin	null	5617	Chemical	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	I. Cross-sectional study of basal and post-TRH and postdexamethasone prolactin levels .
20027486	0	potassium	64,73	11beta-hydroxysteroid_dehydrogenase_2	8,45	potassium	11beta-hydroxysteroid dehydrogenase 2	MESH:D011188	25117(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Role of 11beta-hydroxysteroid_dehydrogenase_2 renal activity in potassium homeostasis in rats with chronic_renal_failure .
11044229	0	potassium	59,68	ACE	0,3	potassium	ACE	MESH:D011188	1636	Chemical	Gene	impact|nmod|START_ENTITY inhibition|dep|impact inhibition|compound|END_ENTITY	ACE inhibition or angiotensin receptor blockade : impact on potassium in renal_failure .
12092742	0	potassium	37,46	ACE	60,63	potassium	ACE	MESH:D011188	1636	Chemical	Gene	excretion|compound|START_ENTITY excretion|nmod|END_ENTITY	Comparative effects on dynamic renal potassium excretion of ACE inhibition versus angiotensin receptor blockade in hypertensive patients with type_II_diabetes_mellitus .
15384026	0	potassium	63,72	ACE	14,17	potassium	ACE	MESH:D011188	1636	Chemical	Gene	inhibitor|nmod|START_ENTITY inhibitor|compound|END_ENTITY	Effects of an ACE inhibitor or angiotensin receptor blocker on potassium in CAPD patients .
11287423	0	potassium	78,87	AKAP79	44,50	potassium	AKAP79	MESH:D011188	9495	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|nmod|channel	Targeting of an A kinase-anchoring protein , AKAP79 , to an inwardly rectifying potassium channel , Kir2 .1 .
11706182	0	potassium	27,36	AKT1	13,17	potassium	AKT1	MESH:D011188	817206(Tax:3702)	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Functions of AKT1 and AKT2 potassium channels determined by studies of single and double mutants of Arabidopsis .
26969743	0	potassium	32,41	AKT1	27,31	potassium	AKT1	MESH:D011188	817206(Tax:3702)	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Overexpression of the rice AKT1 potassium channel affects potassium nutrition and rice drought tolerance .
26969743	0	potassium	58,67	AKT1	27,31	potassium	AKT1	MESH:D011188	817206(Tax:3702)	Chemical	Gene	nutrition|compound|START_ENTITY affects|dobj|nutrition affects|nsubj|Overexpression Overexpression|nmod|channel channel|compound|END_ENTITY	Overexpression of the rice AKT1 potassium channel affects potassium nutrition and rice drought tolerance .
9218788	0	potassium	34,43	AKT1	23,27	potassium	AKT1	MESH:D011188	207	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Tetramerization of the AKT1 plant potassium channel involves its C-terminal cytoplasmic domain .
9572739	0	potassium	20,29	AKT1	15,19	potassium	AKT1	MESH:D011188	817206(Tax:3702)	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	A role for the AKT1 potassium channel in plant nutrition .
21445098	0	potassium	71,80	AKT2	66,70	potassium	AKT2	MESH:D011188	828311(Tax:3702)	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Calcium-dependent modulation and plasma membrane targeting of the AKT2 potassium channel by the CBL4/CIPK6 calcium sensor/protein kinase complex .
11181729	0	potassium	9,18	AKT3	4,8	potassium	AKT3	MESH:D011188	828311(Tax:3702)	Chemical	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	The AKT3 potassium channel protein interacts with the AtPP2CA protein phosphatase 2C .
22056818	0	potassium	43,52	AMIGO	0,5	potassium	AMIGO	MESH:D011188	229715(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY subunit|nmod|channel subunit|nsubj|END_ENTITY	AMIGO is an auxiliary subunit of the Kv2 .1 potassium channel .
2316703	0	potassium	34,43	ANG_II	0,6	potassium	ANG II	MESH:D011188	183	Chemical	Gene	channels|compound|START_ENTITY inhibits|dobj|channels inhibits|nsubj|END_ENTITY	ANG_II inhibits calcium-activated potassium channels from coronary smooth muscle in lipid bilayers .
6259330	0	potassium	68,77	ATPase	54,60	potassium	ATPase	MESH:D011188	1769	Chemical	Gene	phosphatase|compound|START_ENTITY END_ENTITY|nmod|phosphatase	Excess magnesium converts red cell -LRB- sodium + potassium -RRB- ATPase to the potassium phosphatase .
23426512	0	potassium	61,70	Angiotensin_II	1,15	potassium	Angiotensin II	MESH:D011188	183	Chemical	Gene	channels|compound|START_ENTITY Ca|dep|channels activates|dobj|Ca activates|nsubj|END_ENTITY	-LSB- Angiotensin_II activates large-conductance Ca -LRB- 2 + -RRB- - activated potassium channels in human mesenteric artery smooth muscle cells -RSB- .
11849449	0	potassium	97,106	Angiotensin_II_type_1_receptor	0,30	potassium	Angiotensin II type 1 receptor	MESH:D011188	81638(Tax:10116)	Chemical	Gene	deficiency|compound|START_ENTITY induced|nmod|deficiency induced|nsubj|ameliorates ameliorates|amod|END_ENTITY	Angiotensin_II_type_1_receptor blockade ameliorates tubulointerstitial_injury induced by chronic potassium deficiency .
11904452	0	potassium	28,37	AtKC1	0,5	potassium	AtKC1	MESH:D011188	829400(Tax:3702)	Chemical	Gene	channel|nsubj|START_ENTITY channel|advmod|END_ENTITY	AtKC1 , a silent Arabidopsis potassium channel alpha - subunit modulates root hair K + influx .
12842920	0	potassium	69,78	BKCa	64,68	potassium	BKCa	MESH:D011188	83731(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Molecular and functional identification of cyclic_AMP-sensitive BKCa potassium channels -LRB- ZERO variant -RRB- and L-type voltage-dependent calcium channels in single rat juxtaglomerular cells .
17984374	0	potassium	91,100	BKCa	102,106	potassium	BKCa	MESH:D011188	16531(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY channels|appos|END_ENTITY	Aldosterone-induced coronary_dysfunction in transgenic_mice involves the calcium-activated potassium -LRB- BKCa -RRB- channels of vascular smooth muscle cells .
19911462	0	potassium	36,45	BKCa	56,60	potassium	BKCa	MESH:D011188	83731(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|appos|END_ENTITY	Large conductance calcium-activated potassium channels -LRB- BKCa -RRB- modulate trigeminovascular nociceptive transmission .
24397812	0	potassium	27,36	BKCa	15,19	potassium	BKCa	MESH:D011188	83731(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Involvement of BKCa and KV potassium channels in cAMP-induced vasodilatation : their insufficient function in genetic_hypertension .
9662557	0	potassium	63,72	BKCa	83,87	potassium	BKCa	MESH:D011188	100008745(Tax:9986)	Chemical	Gene	channels|compound|START_ENTITY channels|appos|END_ENTITY	Characteristics of single , large-conductance calcium-dependent potassium channels -LRB- BKCa -RRB- from smooth muscle cells isolated from the rabbit mesenteric artery .
17158598	0	potassium	39,48	Bradykinin	0,10	potassium	Bradykinin	MESH:D011188	3827	Chemical	Gene	channels|compound|START_ENTITY activates|dobj|channels activates|nsubj|END_ENTITY	Bradykinin activates calcium-dependent potassium channels in cultured human airway_smooth_muscle cells .
10516298	0	potassium	81,90	CA1	111,114	potassium	CA1	MESH:D011188	759	Chemical	Gene	subtypes|compound|START_ENTITY controlled|nmod|subtypes controlled|nmod|neurons neurons|nummod|END_ENTITY	Dendritic calcium spike initiation and repolarization are controlled by distinct potassium channel subtypes in CA1 pyramidal neurons .
10551004	0	potassium	79,88	CA1	113,116	potassium	CA1	MESH:D011188	759	Chemical	Gene	currents|compound|START_ENTITY modulate|dobj|currents modulate|nmod|neurons neurons|compound|END_ENTITY	An adenosine A3 receptor-selective agonist does not modulate calcium-activated potassium currents in hippocampal CA1 pyramidal neurons .
10650976	0	potassium	41,50	CA1	87,90	potassium	CA1	MESH:D011188	310218(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY activation|nmod|channels activation|nmod|cells cells|nummod|END_ENTITY	Differential activation of ATP-sensitive potassium channels during energy depletion in CA1 pyramidal cells and interneurones of rat hippocampus .
10832017	0	potassium	56,65	CA1	78,81	potassium	CA1	MESH:D011188	310218(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY calcium-activated|dobj|channels calcium-activated|nmod|neurons neurons|nummod|END_ENTITY	Redox modulation of large conductance calcium-activated potassium channels in CA1 pyramidal neurons from adult rat hippocampus .
11082496	0	potassium	65,74	CA1	87,90	potassium	CA1	MESH:D011188	310218(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY calcium-activated|dobj|channels calcium-activated|nmod|pyramidal_neurons pyramidal_neurons|nummod|END_ENTITY	Enhancement in activities of large conductance calcium-activated potassium channels in CA1 pyramidal_neurons of rat hippocampus after transient forebrain_ischemia .
11110813	0	potassium	24,33	CA1	46,49	potassium	CA1	MESH:D011188	759	Chemical	Gene	currents|compound|START_ENTITY currents|nmod|pyramidal pyramidal|compound|END_ENTITY	Differential changes of potassium currents in CA1 pyramidal neurons after transient forebrain_ischemia .
11169627	0	potassium	8,17	CA1	38,41	potassium	CA1	MESH:D011188	310218(Tax:10116)	Chemical	Gene	currents|compound|START_ENTITY neurons|dep|currents neurons|nsubj|hippocampal hippocampal|compound|END_ENTITY	Reduced potassium currents in old rat CA1 hippocampal neurons .
11245064	0	potassium	53,62	CA1	117,120	potassium	CA1	MESH:D011188	310218(Tax:10116)	Chemical	Gene	current|compound|START_ENTITY peptide|nmod|current Effects|nmod|peptide dissociated|nsubj|Effects dissociated|nmod|sector sector|compound|END_ENTITY	Effects of beta-amyloid peptide on transient outward potassium current of acutely dissociated hippocampal neurons in CA1 sector in rats .
11297812	0	potassium	70,79	CA1	92,95	potassium	CA1	MESH:D011188	310218(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|nmod|neurons neurons|nummod|END_ENTITY	Toosendanin-induced inhibition of small-conductance calcium-activated potassium channels in CA1 pyramidal neurons of rat hippocampus .
11738492	0	potassium	22,31	CA1	52,55	potassium	CA1	MESH:D011188	310218(Tax:10116)	Chemical	Gene	activity|compound|START_ENTITY activity|nmod|pyramidal pyramidal|compound|END_ENTITY	Alterations of single potassium channel activity in CA1 pyramidal neurons after transient forebrain_ischemia .
11846964	0	potassium	50,59	CA1	111,114	potassium	CA1	MESH:D011188	310218(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY calcium-activated|dobj|channels calcium-activated|nmod|region region|compound|END_ENTITY	Properties of large conductance calcium-activated potassium channels in pyramidal neurons from the hippocampal CA1 region of adult rats .
11886457	0	potassium	98,107	CA1	161,164	potassium	CA1	MESH:D011188	310218(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|nmod|neurons neurons|compound|END_ENTITY	Transient forebrain_ischemia induces persistent hyperactivity of large conductance Ca2 + - activated potassium channels via oxidation modulation in rat hippocampal CA1 pyramidal neurons .
12020870	0	potassium	66,75	CA1	104,107	potassium	CA1	MESH:D011188	310218(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|nmod|neurons neurons|compound|END_ENTITY	Beta-agkistrodotoxin inhibits large-conductance calcium-activated potassium channels in rat hippocampal CA1 pyramidal neurons .
12042355	0	potassium	36,45	CA1	102,105	potassium	CA1	MESH:D011188	310218(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY hippocampal|nsubj|channels hippocampal|dobj|neurons neurons|nummod|END_ENTITY	Pre - and postsynaptic ATP-sensitive potassium channels during metabolic inhibition of rat hippocampal CA1 neurons .
12177218	0	potassium	62,71	CA1	95,98	potassium	CA1	MESH:D011188	100009083(Tax:9986)	Chemical	Gene	current|compound|START_ENTITY current|nmod|pyramidal pyramidal|compound|END_ENTITY	Age-related enhancement of the slow outward calcium-activated potassium current in hippocampal CA1 pyramidal neurons in vitro .
1356568	0	potassium	19,28	CA1	40,43	potassium	CA1	MESH:D011188	310218(Tax:10116)	Chemical	Gene	current|compound|START_ENTITY current|nmod|neurones neurones|nummod|END_ENTITY	Strychnine-induced potassium current in CA1 pyramidal neurones of the rat hippocampus .
1403796	1	potassium	226,235	CA1	191,194	potassium	CA1	MESH:D011188	759	Chemical	Gene	conductance|compound|START_ENTITY increase|nmod|conductance hippocampal|nmod|increase hippocampal|dobj|cells cells|nmod|END_ENTITY	5-hydroxytryptamine -LRB- 5-HT -RRB- hyperpolarizes hippocampal pyramidal cells in both areas CA1 and CA3 through an increase in potassium conductance .
14746925	0	potassium	24,33	CA1	63,66	potassium	CA1	MESH:D011188	310218(Tax:10116)	Chemical	Gene	currents|compound|START_ENTITY berberine|nmod|currents Effects|nmod|berberine isolated|nsubj|Effects isolated|dobj|neurons neurons|nummod|END_ENTITY	Effects of berberine on potassium currents in acutely isolated CA1 pyramidal neurons of rat hippocampus .
15066048	0	potassium	45,54	CA1	79,82	potassium	CA1	MESH:D011188	310218(Tax:10116)	Chemical	Gene	currents|compound|START_ENTITY outward|dobj|currents outward|nmod|neuron neuron|compound|END_ENTITY	Melatonin inhibits outward delayed rectifier potassium currents in hippocampal CA1 pyramidal neuron via intracellular indole-related domains .
15234075	0	potassium	106,115	CA1	160,163	potassium	CA1	MESH:D011188	310218(Tax:10116)	Chemical	Gene	current|compound|START_ENTITY Effects|nmod|current hippocampal|nsubj|Effects hippocampal|dobj|neurons neurons|nummod|END_ENTITY	Effects of aluminum_chloride on sodium current , transient outward potassium current and delayed rectifier potassium current in acutely isolated rat hippocampal CA1 neurons .
15234075	0	potassium	66,75	CA1	160,163	potassium	CA1	MESH:D011188	310218(Tax:10116)	Chemical	Gene	current|compound|START_ENTITY Effects|nmod|current hippocampal|nsubj|Effects hippocampal|dobj|neurons neurons|nummod|END_ENTITY	Effects of aluminum_chloride on sodium current , transient outward potassium current and delayed rectifier potassium current in acutely isolated rat hippocampal CA1 neurons .
15374744	0	potassium	17,26	CA1	142,145	potassium	CA1	MESH:D011188	310218(Tax:10116)	Chemical	Gene	conductance|compound|START_ENTITY participates|nsubj|conductance participates|nmod|afterpotential afterpotential|nmod|potential potential|nmod|cells cells|compound|END_ENTITY	Sodium-activated potassium conductance participates in the depolarizing afterpotential following a single action potential in rat hippocampal CA1 pyramidal cells .
15621334	0	potassium	35,44	CA1	74,77	potassium	CA1	MESH:D011188	310218(Tax:10116)	Chemical	Gene	currents|compound|START_ENTITY sodium_metabisulfite|nmod|currents Effects|nmod|sodium_metabisulfite isolated|nsubj|Effects isolated|dobj|neurons neurons|nummod|END_ENTITY	Effects of sodium_metabisulfite on potassium currents in acutely isolated CA1 pyramidal neurons of rat hippocampus .
16141270	0	potassium	4,13	CA1	125,128	potassium	CA1	MESH:D011188	310218(Tax:10116)	Chemical	Gene	subunits|compound|START_ENTITY control|nsubj|subunits control|dep|broadening broadening|nmod|neurones neurones|compound|END_ENTITY	Kv4 potassium channel subunits control action potential repolarization and frequency-dependent broadening in rat hippocampal CA1 pyramidal neurones .
16148750	0	potassium	28,37	CA1	86,89	potassium	CA1	MESH:D011188	310218(Tax:10116)	Chemical	Gene	currents|compound|START_ENTITY copper|nmod|currents Effects|nmod|copper dissociated|nsubj|Effects dissociated|xcomp|rat rat|dobj|neurons neurons|compound|END_ENTITY	Effects of copper on A-type potassium currents in acutely dissociated rat hippocampal CA1 neurons .
16706845	0	potassium	38,47	CA1	100,103	potassium	CA1	MESH:D011188	310218(Tax:10116)	Chemical	Gene	IA|amod|START_ENTITY modulation|nmod|IA arachidonic_acid|nsubj|modulation arachidonic_acid|nmod|neurons neurons|compound|END_ENTITY	Oxidative modulation of the transient potassium current IA by intracellular arachidonic_acid in rat CA1 pyramidal neurons .
17317746	0	potassium	17,26	CA1	93,96	potassium	CA1	MESH:D011188	310218(Tax:10116)	Chemical	Gene	currents|compound|START_ENTITY inhibit|nsubj|currents inhibit|dobj|afterdepolarization afterdepolarization|nmod|neurons neurons|compound|END_ENTITY	Dendritic D-type potassium currents inhibit the spike afterdepolarization in rat hippocampal CA1 pyramidal neurons .
17977674	0	potassium	96,105	CA1	56,59	potassium	CA1	MESH:D011188	759	Chemical	Gene	currents|compound|START_ENTITY inhibiting|dobj|currents impairs|advcl|inhibiting impairs|dobj|excitability excitability|nmod|neurons neurons|compound|END_ENTITY	Peroxynitrite donor impairs excitability of hippocampal CA1 neurons by inhibiting voltage-gated potassium currents .
18495361	0	potassium	17,26	CA1	57,60	potassium	CA1	MESH:D011188	310218(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|expression expression|nmod|interneurons interneurons|nummod|END_ENTITY	Dendritic A-type potassium channel subunit expression in CA1 hippocampal interneurons .
18623077	0	potassium	97,106	CA1	56,59	potassium	CA1	MESH:D011188	310218(Tax:10116)	Chemical	Gene	currents|compound|START_ENTITY hippocampus|dobj|currents hippocampus|nmod|study study|nmod|influence influence|nmod|particles particles|nmod|CuO CuO|nmod|END_ENTITY	In vitro study on influence of nano particles of CuO on CA1 pyramidal neurons of rat hippocampus potassium currents .
19895883	0	potassium	22,31	CA1	60,63	potassium	CA1	MESH:D011188	310218(Tax:10116)	Chemical	Gene	currents|compound|START_ENTITY melamine|nmod|currents Effect|nmod|melamine hippocampal|nsubj|Effect hippocampal|dobj|neurons neurons|nummod|END_ENTITY	Effect of melamine on potassium currents in rat hippocampal CA1 neurons .
19947539	0	potassium	26,35	CA1	132,135	potassium	CA1	MESH:D011188	310218(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|nmod|neurons neurons|nummod|END_ENTITY	-LSB- Role of Ca -LRB- 2 + -RRB- - activated potassium channels with high-conductivity in hypoxic preconditioning and posthypoxic hyperexcitability in CA1 hippocampal neurons in vitro -RSB- .
20549616	0	potassium	51,60	CA1	85,88	potassium	CA1	MESH:D011188	759	Chemical	Gene	currents|compound|START_ENTITY effects|nmod|currents effects|nmod|neurons neurons|compound|END_ENTITY	The inhibitory effects of nano-Ag on voltage-gated potassium currents of hippocampal CA1 neurons .
21162184	0	potassium	36,45	CA1	91,94	potassium	CA1	MESH:D011188	310218(Tax:10116)	Chemical	Gene	currents|compound|START_ENTITY sodium_metabisulfite|nmod|currents neurons|amod|sodium_metabisulfite neurons|compound|END_ENTITY	-LSB- Effects of sodium_metabisulfite on potassium currents in acutely isolated rat hippocampal CA1 neurons -RSB- .
22192952	0	potassium	69,78	CA1	103,106	potassium	CA1	MESH:D011188	310218(Tax:10116)	Chemical	Gene	currents|compound|START_ENTITY currents|nmod|neurons neurons|compound|END_ENTITY	Inhibitory effect of tungsten_carbide nanoparticles on voltage-gated potassium currents of hippocampal CA1 neurons .
2302557	0	potassium	25,34	CA1	125,128	potassium	CA1	MESH:D011188	310218(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY Effects|nmod|concentration Effects|nmod|END_ENTITY	Effects of extracellular potassium concentration and postsynaptic membrane potential on calcium-induced potentiation in area CA1 of rat hippocampus .
23274715	0	potassium	105,114	CA1	71,74	potassium	CA1	MESH:D011188	310218(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY inhibition|nmod|channels increases|nmod|inhibition increases|dobj|excitability excitability|nmod|neurons neurons|compound|END_ENTITY	Multi-walled carbon nanotube increases the excitability of hippocampal CA1 neurons through inhibition of potassium channels in rat 's brain slices .
23486576	0	potassium	35,44	CA1	92,95	potassium	CA1	MESH:D011188	310218(Tax:10116)	Chemical	Gene	blockers|compound|START_ENTITY Comparison|nmod|blockers Comparison|nmod|neurons neurons|compound|END_ENTITY	Comparison of effects of ATP-gated potassium channel blockers on activity variations of rat CA1 pyramidal neurons in hippocampal slices triggered by short-term hypoxia .
24336711	0	potassium	26,35	CA1	65,68	potassium	CA1	MESH:D011188	12346(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY channels|nmod|dendrites dendrites|nmod|pyramidal pyramidal|compound|END_ENTITY	Loss of functional A-type potassium channels in the dendrites of CA1 pyramidal neurons from a mouse model of fragile_X_syndrome .
2442026	0	potassium	64,73	CA1	102,105	potassium	CA1	MESH:D011188	759	Chemical	Gene	epileptiform_discharges|nmod|START_ENTITY Control|nmod|epileptiform_discharges Control|dep|study study|nmod|subfield subfield|compound|END_ENTITY	Control of spontaneous epileptiform_discharges by extracellular potassium : an `` in vitro '' study in the CA1 subfield of the hippocampal slice .
24606584	0	potassium	53,62	CA1	75,78	potassium	CA1	MESH:D011188	759	Chemical	Gene	channels|compound|START_ENTITY distributions|nmod|channels distributions|nmod|cells cells|nummod|END_ENTITY	Distinct axo-somato-dendritic distributions of three potassium channels in CA1 hippocampal pyramidal cells .
2999648	0	potassium	33,42	CA1	55,58	potassium	CA1	MESH:D011188	310218(Tax:10116)	Chemical	Gene	noradrenaline|nmod|START_ENTITY currents|amod|noradrenaline currents|nmod|END_ENTITY	Effects of noradrenaline on some potassium currents in CA1 neurones in rat hippocampal slices .
3697739	0	potassium	29,38	CA1	59,62	potassium	CA1	MESH:D011188	759	Chemical	Gene	accumulation|compound|START_ENTITY accumulation|nmod|region region|compound|END_ENTITY	The sources of extracellular potassium accumulation in the CA1 region of hippocampal slices .
3701404	0	potassium	37,46	CA1	81,84	potassium	CA1	MESH:D011188	100720116	Chemical	Gene	current|compound|START_ENTITY decreases|dobj|current decreases|advcl|guinea_pig guinea_pig|dobj|cells cells|compound|END_ENTITY	Histamine decreases calcium-mediated potassium current in guinea_pig hippocampal CA1 pyramidal cells .
7444438	0	potassium	60,69	CA1	95,98	potassium	CA1	MESH:D011188	759	Chemical	Gene	potential|compound|START_ENTITY potential|nmod|cells cells|compound|END_ENTITY	Epileptiform burst afterhyperolarization : calcium-dependent potassium potential in hippocampal CA1 pyramidal cells .
7552366	0	potassium	86,95	CA1	37,40	potassium	CA1	MESH:D011188	310218(Tax:10116)	Chemical	Gene	conductance|compound|START_ENTITY inducing|nmod|conductance rat|advcl|inducing rat|dobj|neurons neurons|nummod|END_ENTITY	Hydrogen_peroxide hyperpolarizes rat CA1 pyramidal neurons by inducing an increase in potassium conductance .
7821278	0	potassium	49,58	CA1	94,97	potassium	CA1	MESH:D011188	12346(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|area area|nummod|END_ENTITY	Effects of glutamate , N-methyl-D-aspartate , high potassium , and hypoxia on unit discharges in CA1 area of hippocampal slices of DBA and C57 mice .
8492147	0	potassium	19,28	CA1	40,43	potassium	CA1	MESH:D011188	310218(Tax:10116)	Chemical	Gene	current|compound|START_ENTITY current|nmod|neurons neurons|nummod|END_ENTITY	Serotonin-operated potassium current in CA1 neurons dissociated from rat hippocampus .
8576855	0	potassium	14,23	CA1	89,92	potassium	CA1	MESH:D011188	310218(Tax:10116)	Chemical	Gene	currents|compound|START_ENTITY currents|nmod|neurones neurones|nmod|END_ENTITY	Voltage-gated potassium currents in stratum oriens-alveus inhibitory neurones of the rat CA1 hippocampus .
8592191	0	potassium	32,41	CA1	118,121	potassium	CA1	MESH:D011188	310218(Tax:10116)	Chemical	Gene	currents|compound|START_ENTITY Comparison|nmod|currents isolated|nsubj|Comparison isolated|nmod|END_ENTITY	Comparison of voltage-dependent potassium currents in rat pyramidal neurons acutely isolated from hippocampal regions CA1 and CA3 .
8728473	0	potassium	48,57	CA1	89,92	potassium	CA1	MESH:D011188	310218(Tax:10116)	Chemical	Gene	current|compound|START_ENTITY current|nmod|neurons neurons|amod|END_ENTITY	Tetrahydroberberine suppresses dopamine-induced potassium current in acutely dissociated CA1 pyramidal neurons from rat hippocampus .
9120578	0	potassium	30,39	CA1	97,100	potassium	CA1	MESH:D011188	310218(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY Contribution|nmod|channels hippocampal|nsubj|Contribution hippocampal|dobj|neurons neurons|nummod|END_ENTITY	Contribution of ATP-sensitive potassium channels to hypoxic_hyperpolarization in rat hippocampal CA1 neurons in vitro .
9509993	0	potassium	63,72	CA1	95,98	potassium	CA1	MESH:D011188	310218(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY concentration|nmod|END_ENTITY	Effects of barium on stimulus induced changes in extracellular potassium concentration in area CA1 of hippocampal slices from normal and pilocarpine-treated epileptic rats .
9693779	0	potassium	10,19	CA1	41,44	potassium	CA1	MESH:D011188	310218(Tax:10116)	Chemical	Gene	currents|compound|START_ENTITY currents|acl|maturing maturing|dobj|neurones neurones|nummod|END_ENTITY	Sustained potassium currents in maturing CA1 hippocampal neurones .
9774157	0	potassium	49,58	CA1	126,129	potassium	CA1	MESH:D011188	310218(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY Inhibition|nmod|channels facilitate|nsubj|Inhibition facilitate|dobj|induction induction|nmod|potentiation potentiation|nmod|region region|compound|END_ENTITY	Inhibition of apamin-sensitive calcium dependent potassium channels facilitate the induction of long-term potentiation in the CA1 region of rat hippocampus in vitro .
18686609	0	potassium	85,94	CA3	122,125	potassium	CA3	MESH:D011188	54232(Tax:10116)	Chemical	Gene	current|compound|START_ENTITY current|nmod|neurons neurons|compound|END_ENTITY	-LSB- Inhibitory effect of unaggregated amyloid beta protein -LRB- 25-35 -RRB- on delayed rectifier potassium current in rat hippocampal CA3 pyramidal neurons -RSB- .
20303341	0	potassium	91,100	CA3	30,33	potassium	CA3	MESH:D011188	54232(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Characterizing the persistent CA3 interneuronal spiking activity in elevated extracellular potassium in the young rat hippocampus .
2709097	2	potassium	63,72	CA3	132,135	potassium	CA3	MESH:D011188	761	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|neurons neurons|compound|END_ENTITY	Effects of extracellular potassium , furosemide , and membrane potential on ECl - in hippocampal CA3 neurons .
14978245	0	potassium	92,101	CB1_cannabinoid_receptors	115,140	potassium	CB1 cannabinoid receptors	MESH:D011188	1268	Chemical	Gene	channels|compound|START_ENTITY channels|nmod|END_ENTITY	Endocannabinoids modulate N-type calcium channels and G-protein-coupled inwardly rectifying potassium channels via CB1_cannabinoid_receptors heterologously expressed in mammalian neurons .
19961728	0	potassium	7,16	CD4	50,53	potassium	CD4	MESH:D011188	920	Chemical	Gene	changes|compound|START_ENTITY changes|nmod|END_ENTITY	-LSB- Kv1 .3 potassium channel expression changes after CD4 -LRB- + -RRB- and subsets CD28 -LRB- null -RRB- / CD28 -LRB- + -RRB- T cells activation in peripheral blood of patients with acute_coronary_syndrome -RSB- .
21438014	0	potassium	29,38	CXCR4	51,56	potassium	CXCR4	MESH:D011188	60628(Tax:10116)	Chemical	Gene	current|compound|START_ENTITY current|nmod|END_ENTITY	HIV-1 gp120 enhances outward potassium current via CXCR4 and cAMP-dependent protein kinase A signaling in cultured rat microglia .
2340419	0	potassium	48,57	Ca2	31,34	potassium	Ca2	MESH:D011188	760	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dep|channels	-LSB- Rubidium permeability through Ca2 -LRB- + -RRB- - activated potassium channels in human erythrocytes -RSB- .
26445872	0	potassium	92,101	Corticotropin-releasing_factor	0,30	potassium	Corticotropin-releasing factor	MESH:D011188	81648(Tax:10116)	Chemical	Gene	increases|nmod|START_ENTITY increases|nsubj|END_ENTITY	Corticotropin-releasing_factor increases Purkinje neuron excitability by modulating sodium , potassium , and Ih currents .
9263909	0	potassium	64,73	Corticotropin_releasing_hormone	0,31	potassium	Corticotropin releasing hormone	MESH:D011188	81648(Tax:10116)	Chemical	Gene	current|compound|START_ENTITY inhibits|dobj|current inhibits|nsubj|END_ENTITY	Corticotropin_releasing_hormone inhibits an inwardly rectifying potassium current in rat corticotropes .
15671030	0	potassium	36,45	DPP10	0,5	potassium	DPP10	MESH:D011188	363972(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY modulates|dobj|channels modulates|nsubj|END_ENTITY	DPP10 modulates Kv4-mediated A-type potassium channels .
8496800	0	potassium	76,85	DRK1	63,67	potassium	DRK1	MESH:D011188	378535(Tax:8355)	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dep|channels	2,3-Butanedione _ monoxime -LRB- BDM -RRB- inhibition of delayed rectifier DRK1 -LRB- Kv2 .1 -RRB- potassium channels expressed in Xenopus oocytes .
8723646	0	potassium	39,48	DUK1	58,62	potassium	DUK1	MESH:D011188	853352(Tax:4932)	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	The S. _ cerevisiae outwardly-rectifying potassium channel -LRB- DUK1 -RRB- identifies a new family of channels with duplicated pore domains .
25025038	0	potassium	54,63	Dipeptidyl_peptidase_10	0,23	potassium	Dipeptidyl peptidase 10	MESH:D011188	57628	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|dep|channel	Dipeptidyl_peptidase_10 -LRB- DPP10 -LRB- 789 -RRB- -RRB- : a voltage gated potassium channel associated protein is abnormally expressed in Alzheimer 's and other neurodegenerative_diseases .
11211100	0	potassium	85,94	EAG	81,84	potassium	EAG	MESH:D011188	3756	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Cytoskeletal interactions determine the electrophysiological properties of human EAG potassium channels .
23319419	0	potassium	113,122	EAG	101,104	potassium	EAG	MESH:D011188	3756	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	ICA-105574 interacts with a common binding site to elicit opposite effects on inactivation gating of EAG and ERG potassium channels .
20708613	0	potassium	33,42	EAG1	28,32	potassium	EAG1	MESH:D011188	3756	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Current inhibition of human EAG1 potassium channels by the Ca2 + binding protein S100B .
22732247	0	potassium	126,135	EAG1	121,125	potassium	EAG1	MESH:D011188	16510(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Structural , biochemical , and functional characterization of the cyclic nucleotide binding homology domain from the mouse EAG1 potassium channel .
11943152	0	potassium	46,55	EAG2	41,45	potassium	EAG2	MESH:D011188	27133	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Functional distinction of human EAG1 and EAG2 potassium channels .
26258683	0	potassium	5,14	EAG2	0,4	potassium	EAG2	MESH:D011188	27133	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	EAG2 potassium channel with evolutionarily conserved function as a brain_tumor target .
12388285	0	potassium	56,65	ERG	52,55	potassium	ERG	MESH:D011188	2078	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Functional and pharmacological properties of canine ERG potassium channels .
16155403	0	potassium	25,34	ERG	21,24	potassium	ERG	MESH:D011188	2078	Chemical	Gene	START_ENTITY|csubj|targeting targeting|nmod|END_ENTITY	In vivo targeting of ERG potassium channels in mice and dogs by a positron-emitting analogue of fluoroclofilium .
18448609	0	potassium	72,81	ERG	83,86	potassium	ERG	MESH:D011188	100136713(Tax:8022)	Chemical	Gene	START_ENTITY|dobj|channels channels|appos|END_ENTITY	Electrophysiological properties and expression of the delayed rectifier potassium -LRB- ERG -RRB- channels in the heart of thermally acclimated rainbow_trout .
12063283	0	potassium	55,64	ERG1	32,36	potassium	ERG1	MESH:D011188	3757	Chemical	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression and coassociation of ERG1 , KCNQ1 , and KCNE1 potassium channel proteins in horse heart .
12612061	0	potassium	35,44	ERG1	28,32	potassium	ERG1	MESH:D011188	16511(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Selective knockout of mouse ERG1 B potassium channel eliminates I -LRB- Kr -RRB- in adult ventricular myocytes and elicits episodes of abrupt_sinus_bradycardia .
19921238	0	potassium	42,51	ERG1	37,41	potassium	ERG1	MESH:D011188	117018(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Expression and immunolocalization of ERG1 potassium channels in the rat kidney .
23138560	0	potassium	30,39	ERG1	25,29	potassium	ERG1	MESH:D011188	117018(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|nummod|END_ENTITY	Functional expression of ERG1 potassium channels in rat alveolar macrophages .
17610913	0	potassium	19,28	ERG2	14,18	potassium	ERG2	MESH:D011188	81033	Chemical	Gene	START_ENTITY|nsubj|Activation Activation|nmod|END_ENTITY	Activation of ERG2 potassium channels by the diphenylurea_NS1643 .
10617464	0	potassium	35,44	EXP-2	29,34	potassium	EXP-2	MESH:D011188	179003(Tax:6239)	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	A mutation in the C. _ elegans EXP-2 potassium channel that alters feeding behavior .
20855938	0	potassium	75,84	Eag	71,74	potassium	Eag	MESH:D011188	32428(Tax:7227)	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Intracellular linkers are involved in Mg2 + - dependent modulation of the Eag potassium channel .
21059657	0	potassium	33,42	Eag	29,32	potassium	Eag	MESH:D011188	3756	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Intracellular regions of the Eag potassium channel play a critical role in generation of voltage-dependent currents .
21138547	0	potassium	8,17	Eag	4,7	potassium	Eag	MESH:D011188	3756	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	The Eag potassium channel as a new prognostic marker in ovarian_cancer .
15964838	0	potassium	31,40	Eag1	17,21	potassium	Eag1	MESH:D011188	3756	Chemical	Gene	channels|compound|START_ENTITY channels|amod|Glycosylation Glycosylation|nmod|END_ENTITY	Glycosylation of Eag1 -LRB- Kv10 .1 -RRB- potassium channels : intracellular trafficking and functional consequences .
17022810	0	potassium	23,32	Eag1	18,22	potassium	Eag1	MESH:D011188	3756	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Overexpression of Eag1 potassium channels in clinical tumours .
17671204	0	potassium	47,56	Eag1	42,46	potassium	Eag1	MESH:D011188	3756	Chemical	Gene	function|compound|START_ENTITY function|amod|END_ENTITY	Monoclonal antibody blockade of the human Eag1 potassium channel function exerts antitumor activity .
17873312	0	potassium	28,37	Eag1	23,27	potassium	Eag1	MESH:D011188	3756	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Aberrant expression of Eag1 potassium channels in gastric_cancer patients and cell lines .
18063306	0	potassium	47,56	Eag1	33,37	potassium	Eag1	MESH:D011188	65198(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|localization localization|nmod|END_ENTITY	Differential localization of rat Eag1 and Eag2 potassium channels in the retina .
21646358	0	potassium	78,87	Eag1	73,77	potassium	Eag1	MESH:D011188	65198(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Distal end of carboxyl terminus is not essential for the assembly of rat Eag1 potassium channels .
21887469	0	potassium	5,14	Eag1	0,4	potassium	Eag1	MESH:D011188	3756	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Eag1 potassium channels as markers of cervical_dysplasia .
22048886	0	potassium	24,33	Eag1	18,22	potassium	Eag1	MESH:D011188	65198(Tax:10116)	Chemical	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Ether - - go-go 1 -LRB- Eag1 -RRB- potassium channel expression in dopaminergic neurons of basal ganglia is modulated by 6-hydroxydopamine lesion .
22911758	0	potassium	42,51	Eag1	37,41	potassium	Eag1	MESH:D011188	65198(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	14-3-3 is a binding partner of rat Eag1 potassium channels .
17877911	0	potassium	30,39	Endothelin-1	0,12	potassium	Endothelin-1	MESH:D011188	13614(Tax:10090)	Chemical	Gene	currents|compound|START_ENTITY inhibits|dobj|currents inhibits|nsubj|END_ENTITY	Endothelin-1 inhibits outward potassium currents in mouse outer sulcus cells .
7522332	0	potassium	39,48	Endothelin-1	0,12	potassium	Endothelin-1	MESH:D011188	1906	Chemical	Gene	channels|compound|START_ENTITY inhibits|dobj|channels inhibits|nsubj|END_ENTITY	Endothelin-1 inhibits inward rectifier potassium channels and activates nonspecific cation channels in cultured endothelial cells .
8968552	0	potassium	64,73	Endothelin-1	0,12	potassium	Endothelin-1	MESH:D011188	100009270(Tax:9986)	Chemical	Gene	current|compound|START_ENTITY inhibition|nmod|current inhibition|amod|END_ENTITY	Endothelin-1 mediated inhibition of the acetylcholine-activated potassium current from rabbit isolated atrial cardiomyocytes .
17322986	0	potassium	54,63	Erg	49,52	potassium	Erg	MESH:D011188	170909(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|changes changes|appos|END_ENTITY	Circadian changes of ether-a-go-go-related-gene -LRB- Erg -RRB- potassium channel transcripts in the rat pancreas and beta-cell .
20212103	0	potassium	98,107	Erg	94,97	potassium	Erg	MESH:D011188	37843(Tax:7227)	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	A Drosophila behavioral mutant , down_and_out -LRB- dao -RRB- , is defective in an essential regulator of Erg potassium channels .
24133274	0	potassium	4,13	Erg	0,3	potassium	Erg	MESH:D011188	13876(Tax:10090)	Chemical	Gene	currents|compound|START_ENTITY currents|compound|END_ENTITY	Erg potassium currents of neonatal mouse Purkinje cells exhibit fast gating kinetics and are inhibited by mGluR1 activation .
24706772	0	potassium	28,37	Erg	24,27	potassium	Erg	MESH:D011188	2078	Chemical	Gene	gating|compound|START_ENTITY gating|compound|END_ENTITY	Functional evolution of Erg potassium channel gating reveals an ancient origin for IKr .
18669623	0	potassium	76,85	Ether-a-go-go-related_gene	0,26	potassium	Ether-a-go-go-related gene	MESH:D011188	13876(Tax:10090)	Chemical	Gene	current|compound|START_ENTITY candidate|nmod|current candidate|dep|END_ENTITY	Ether-a-go-go-related_gene 3 is the main candidate for the E-4031-sensitive potassium current in the pacemaker interstitial cells of Cajal .
15466192	0	potassium	14,23	Ether_a_go-go	0,13	potassium	Ether a go-go	MESH:D011188	3756	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Ether_a_go-go potassium channels as human cervical cancer markers .
15819715	0	potassium	19,28	FDG-PET_and_MRI	0,15	potassium	FDG-PET and MRI	MESH:D011188	78996	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|nmod|channel	FDG-PET_and_MRI in potassium channel antibody-associated non-paraneoplastic limbic_encephalitis : correlation with clinical course and neuropsychology .
9729621	0	potassium	27,36	FGF-1	49,54	potassium	FGF-1	MESH:D011188	444686(Tax:8355)	Chemical	Gene	currents|compound|START_ENTITY currents|nmod|END_ENTITY	Differential regulation of potassium currents by FGF-1 and FGF-2 in embryonic Xenopus_laevis myocytes .
10701813	0	potassium	63,72	G-protein_beta3	6,21	potassium	G-protein beta3	MESH:D011188	2784	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|variant variant|compound|END_ENTITY	Human G-protein_beta3 subunit variant is associated with serum potassium and total cholesterol levels but not with blood pressure .
10889209	0	potassium	83,92	GIRK1	17,22	potassium	GIRK1	MESH:D011188	3760	Chemical	Gene	function|compound|START_ENTITY consequences|nmod|function has|dobj|consequences has|nsubj|Glycosylation Glycosylation|nmod|END_ENTITY	Glycosylation of GIRK1 at Asn119 and ROMK1 at Asn117 has different consequences in potassium channel function .
19636962	0	potassium	102,111	GIRK1	123,128	potassium	GIRK1	MESH:D011188	16519(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY rectifying|dobj|channel inwardly|acl|rectifying inwardly|dep|END_ENTITY	Backbone resonance assignments for the cytoplasmic regions of G protein-activated inwardly rectifying potassium channel 1 -LRB- GIRK1 -RRB- .
21075842	0	potassium	140,149	GIRK1	161,166	potassium	GIRK1	MESH:D011188	3760	Chemical	Gene	channel|compound|START_ENTITY rectifying|dobj|channel pore|acl|rectifying rearrangements|nmod|pore rearrangements|dep|END_ENTITY	NMR analyses of the Gbetagamma binding and conformational rearrangements of the cytoplasmic pore of G protein-activated inwardly rectifying potassium channel 1 -LRB- GIRK1 -RRB- .
7576657	0	potassium	80,89	GIRK1	74,79	potassium	GIRK1	MESH:D011188	3760	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Identification of structural elements involved in G protein gating of the GIRK1 potassium channel .
7777206	0	potassium	34,43	GIRK1	54,59	potassium	GIRK1	MESH:D011188	50599(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|appos|END_ENTITY	Activation of inwardly rectifying potassium channels -LRB- GIRK1 -RRB- by co-expressed rat brain cannabinoid receptors in Xenopus oocytes .
7822283	0	potassium	66,75	GIRK1	85,90	potassium	GIRK1	MESH:D011188	50599(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Agonist-induced desensitization of the mu opioid receptor-coupled potassium channel -LRB- GIRK1 -RRB- .
8088798	0	potassium	44,53	GIRK1	63,68	potassium	GIRK1	MESH:D011188	3760	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Human G-protein-coupled inwardly rectifying potassium channel -LRB- GIRK1 -RRB- gene -LRB- KCNJ3 -RRB- : localization to chromosome 2 and identification of a simple tandem repeat polymorphism .
8821795	0	potassium	49,58	GIRK1	43,48	potassium	GIRK1	MESH:D011188	50599(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Colocalization of mu opioid receptors with GIRK1 potassium channels in the rat brain : an immunocytochemical study .
9223341	0	potassium	138,147	GIRK1	157,162	potassium	GIRK1	MESH:D011188	16519(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Opioid receptors from a lower vertebrate -LRB- Catostomus_commersoni -RRB- : sequence , pharmacology , coupling to a G-protein-gated inward-rectifying potassium channel -LRB- GIRK1 -RRB- , and evolution .
9426226	0	potassium	88,97	GIRK1	107,112	potassium	GIRK1	MESH:D011188	50599(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Coupling of rat somatostatin receptor subtypes to a G-protein gated inwardly rectifying potassium channel -LRB- GIRK1 -RRB- .
14596925	0	potassium	44,53	GORK	67,71	potassium	GORK	MESH:D011188	833728(Tax:3702)	Chemical	Gene	gene|compound|START_ENTITY Regulation|nmod|gene END_ENTITY|nsubj|Regulation	Regulation of the ABA-sensitive Arabidopsis potassium channel gene GORK in response to water stress .
1711661	0	potassium	18,27	Galanin	0,7	potassium	Galanin	MESH:D011188	29141(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY increases|dobj|release increases|nsubj|END_ENTITY	Galanin increases potassium evoked release of -LSB- 3H -RSB- 5-hydroxytryptamine from rat hypothalamic synaptosomal preparations .
9813023	0	potassium	91,100	Gbeta	73,78	potassium	Gbeta	MESH:D011188	8801	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Regulators_of_G_protein_signaling -LRB- RGS -RRB- proteins constitutively activate Gbeta gamma-gated potassium channels .
23236146	0	potassium	73,82	Girk1	27,32	potassium	Girk1	MESH:D011188	3760	Chemical	Gene	activity|compound|START_ENTITY subunit|dobj|activity subunit|nsubj|elements elements|nmod|END_ENTITY	Structural elements in the Girk1 subunit that potentiate G protein-gated potassium channel activity .
12198249	0	potassium	58,67	Glucagon-like_peptide-1	0,23	potassium	Glucagon-like peptide-1	MESH:D011188	2641	Chemical	Gene	channels|compound|START_ENTITY inhibits|dobj|channels inhibits|nsubj|END_ENTITY	Glucagon-like_peptide-1 inhibits pancreatic ATP-sensitive potassium channels via a protein kinase A - and ADP-dependent mechanism .
20003076	0	potassium	47,56	Glucagon-like_peptide-1	0,23	potassium	Glucagon-like peptide-1	MESH:D011188	14526(Tax:10090)	Chemical	Gene	currents|compound|START_ENTITY inhibits|dobj|currents inhibits|nsubj|END_ENTITY	Glucagon-like_peptide-1 inhibits voltage-gated potassium currents in mouse nodose ganglion neurons .
10028924	0	potassium	19,28	HERG	14,18	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dobj|channels	Modulation of HERG potassium channels by extracellular magnesium and quinidine .
10187793	0	potassium	79,88	HERG	74,78	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dobj|channels	Long_QT_syndrome-associated mutations in the Per-Arnt-Sim -LRB- PAS -RRB- domain of HERG potassium channels accelerate channel deactivation .
10208308	0	potassium	82,91	HERG	77,81	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Inhibitory effects of the class III antiarrhythmic drug amiodarone on cloned HERG potassium channels .
10219239	0	potassium	16,25	HERG	40,44	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channels|compound|START_ENTITY forms|dobj|channels forms|nmod|END_ENTITY	MiRP1 forms IKr potassium channels with HERG and is associated with cardiac_arrhythmia .
10226095	0	potassium	122,131	HERG	109,113	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channel|amod|START_ENTITY channel|compound|END_ENTITY	Novel mechanism associated with an inherited cardiac_arrhythmia : defective protein trafficking by the mutant HERG -LRB- G601S -RRB- potassium channel .
10325236	0	potassium	78,87	HERG	73,77	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Mechanism of block and identification of the verapamil binding domain to HERG potassium channels .
10376921	0	potassium	14,23	HERG	9,13	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dobj|channels	Block of HERG potassium channels by the antihistamine astemizole and its metabolites desmethylastemizole and norastemizole .
10398876	0	potassium	144,153	HERG	14,18	potassium	HERG	MESH:D011188	3757	Chemical	Gene	IKr|compound|START_ENTITY encode|nmod|IKr known|xcomp|encode Modulation|acl|known Modulation|nmod|properties properties|compound|END_ENTITY	Modulation of HERG potassium channel properties by external pH. We expressed the human eag-related gene -LRB- HERG -RRB- , known to encode for the cardiac potassium channel IKr , in Chinese_hamster_ovary -LRB- CHO -RRB- cells .
10398876	0	potassium	19,28	HERG	14,18	potassium	HERG	MESH:D011188	3757	Chemical	Gene	properties|compound|START_ENTITY properties|compound|END_ENTITY	Modulation of HERG potassium channel properties by external pH. We expressed the human eag-related gene -LRB- HERG -RRB- , known to encode for the cardiac potassium channel IKr , in Chinese_hamster_ovary -LRB- CHO -RRB- cells .
10488078	0	potassium	63,72	HERG	58,62	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Deletion of protein kinase A phosphorylation sites in the HERG potassium channel inhibits activation shift by protein kinase A .
10510456	0	potassium	58,67	HERG	52,56	potassium	HERG	MESH:D011188	3757	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|gene gene|appos|END_ENTITY	Inhibition of the human ether-a-go-go-related gene -LRB- HERG -RRB- potassium channel by cisapride : affinity for open and inactivated states .
10510461	0	potassium	59,68	HERG	54,58	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dobj|channels	Inhibition of the current of heterologously expressed HERG potassium channels by imipramine and amitriptyline .
10531299	0	potassium	61,70	HERG	56,60	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Correction of defective protein trafficking of a mutant HERG potassium channel in human long_QT_syndrome .
10841244	0	potassium	24,33	HERG	19,23	potassium	HERG	MESH:D011188	3757	Chemical	Gene	mutation|compound|START_ENTITY mutation|compound|END_ENTITY	Homozygosity for a HERG potassium channel mutation causes a severe form of long_QT_syndrome : identification of an apparent founder mutation in the Finns .
10898527	0	potassium	23,32	HERG	18,22	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dobj|channels	Altered gating of HERG potassium channels by cobalt and lanthanum .
10952689	0	potassium	19,28	HERG	14,18	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dobj|channels	Inhibition of HERG potassium channels by the antimalarial agent halofantrine .
11033107	0	potassium	95,104	HERG	89,93	potassium	HERG	MESH:D011188	3757	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|azimilide azimilide|nmod|gene gene|appos|END_ENTITY	Comparative effects of azimilide and ambasilide on the human ether-a-go-go-related gene -LRB- HERG -RRB- potassium channel .
11104572	0	potassium	5,14	HERG	0,4	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	HERG potassium channels are more frequently expressed in human endometrial_cancer as compared to non-cancerous endometrium .
11164846	0	potassium	45,54	HERG	40,44	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dobj|channels	Antiarrhythmic drug carvedilol inhibits HERG potassium channels .
11278781	0	potassium	61,70	HERG	56,60	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Analysis of the cyclic nucleotide binding domain of the HERG potassium channel and interactions with KCNE2 .
11282296	0	potassium	44,53	HERG	39,43	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|dobj|channel	Regulation of the cardiac repolarizing HERG potassium channel by protein kinase A. Protein kinase A is an enzyme that regulates many cellular processes and is activated in many pathological conditions such as stress and various types of heart_failure .
11524404	0	potassium	77,86	HERG	72,76	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Long-QT_syndrome-associated missense mutations in the pore helix of the HERG potassium channel .
11689132	0	potassium	80,89	HERG	75,79	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|dobj|channel	Development and evaluation of high throughput functional assay methods for HERG potassium channel .
11744013	0	potassium	19,28	HERG	14,18	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dobj|channels	Inhibition of HERG potassium channels by cocaethylene : a metabolite of cocaine and ethanol .
11805215	0	potassium	94,103	HERG	88,92	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channels|compound|START_ENTITY gene|dep|channels gene|appos|END_ENTITY	The antidepressant drug fluoxetine is an inhibitor of human ether-a-go-go-related gene -LRB- HERG -RRB- potassium channels .
11926362	0	potassium	23,32	HERG	18,22	potassium	HERG	MESH:D011188	3757	Chemical	Gene	assay|compound|START_ENTITY assay|compound|END_ENTITY	A high-throughput HERG potassium channel function assay : an old assay with a new look .
12007180	0	potassium	54,63	HERG	49,53	potassium	HERG	MESH:D011188	3757	Chemical	Gene	liability|compound|START_ENTITY liability|compound|END_ENTITY	A virtual screening method for prediction of the HERG potassium channel liability of compound libraries .
12063277	0	potassium	71,80	HERG	66,70	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dobj|channels	Role of glycosylation in cell surface expression and stability of HERG potassium channels .
12065733	0	potassium	26,35	HERG	78,82	potassium	HERG	MESH:D011188	3757	Chemical	Gene	Blockade|nmod|START_ENTITY channel|nsubj|Blockade channel|dobj|gene gene|appos|END_ENTITY	Blockade of human cardiac potassium channel human ether-a-go-go-related gene -LRB- HERG -RRB- by macrolide antibiotics .
12086981	0	potassium	59,68	HERG	54,58	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dobj|channels	Inhibition of the current of heterologously expressed HERG potassium channels by flecainide and comparison with quinidine , propafenone and lignocaine .
12133532	0	potassium	50,59	HERG	45,49	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dobj|channels	Protein kinase A-mediated phosphorylation of HERG potassium channels in a human cell line .
12176129	0	potassium	89,98	HERG	84,88	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dobj|channels	The anti-malarial drug halofantrine and its metabolite N-desbutylhalofantrine block HERG potassium channels .
12200695	0	potassium	5,14	HERG	0,4	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	HERG potassium channels are constitutively expressed in primary human acute_myeloid_leukemias and regulate cell proliferation of normal and leukemic hemopoietic progenitors .
12354768	0	potassium	55,64	HERG	73,77	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channel|compound|START_ENTITY domain|nmod|channel mutation|nmod|domain END_ENTITY|nsubj|mutation	A novel mutation -LRB- T65P -RRB- in the PAS domain of the human potassium channel HERG results in the long_QT_syndrome by trafficking_deficiency .
12357160	0	potassium	27,36	HERG	22,26	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dobj|channels	Kinetic modulation of HERG potassium channels by the volatile anesthetic halothane .
12407082	0	potassium	76,85	HERG	71,75	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Structural and functional role of the extracellular s5-p linker in the HERG potassium channel .
12689355	0	potassium	97,106	HERG	92,96	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Interaction between tetraethylammonium and permeant cations at the inactivation gate of the HERG potassium channel .
12729675	0	potassium	25,34	HERG	20,24	potassium	HERG	MESH:D011188	3757	Chemical	Gene	inhibition|compound|START_ENTITY END_ENTITY|dobj|inhibition	Characterization of HERG potassium channel inhibition using CoMSiA 3D QSAR and homology modeling approaches .
12788816	0	potassium	52,61	HERG	47,51	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dobj|channels	The antipsychotic drug chlorpromazine inhibits HERG potassium channels .
12827215	0	potassium	26,35	HERG	21,25	potassium	HERG	MESH:D011188	3757	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of cloned HERG potassium channels by the antiestrogen tamoxifen .
12829172	0	potassium	19,28	HERG	14,18	potassium	HERG	MESH:D011188	3757	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of HERG potassium channel activation by protein_kinase_C independent of direct phosphorylation of the channel protein .
12839862	0	potassium	17,26	HERG	12,16	potassium	HERG	MESH:D011188	3757	Chemical	Gene	currents|compound|START_ENTITY END_ENTITY|dobj|currents	Blockade of HERG potassium currents by fluvoxamine : incomplete attenuation by S6 mutations at F656 or Y652 .
12860380	0	potassium	45,54	HERG	40,44	potassium	HERG	MESH:D011188	3757	Chemical	Gene	currents|compound|START_ENTITY END_ENTITY|dobj|currents	Preferential closed channel blockade of HERG potassium currents by chemically synthesised BeKm-1 scorpion toxin .
12928493	0	potassium	74,83	HERG	69,73	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dobj|channels	Gating currents associated with intramembrane charge displacement in HERG potassium channels .
14499861	0	potassium	85,94	HERG	110,114	potassium	HERG	MESH:D011188	3757	Chemical	Gene	KCNH2|compound|START_ENTITY KCNH2|appos|END_ENTITY	Functional characterization of the common amino_acid 897 polymorphism of the cardiac potassium channel KCNH2 -LRB- HERG -RRB- .
14642687	0	potassium	56,65	HERG	107,111	potassium	HERG	MESH:D011188	3757	Chemical	Gene	START_ENTITY|dep|improves improves|nmod|patients patients|nmod|mutations mutations|compound|END_ENTITY	A new oral therapy for long_QT_syndrome : long-term oral potassium improves repolarization in patients with HERG mutations .
14674677	0	potassium	90,99	HERG	85,89	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Characterization of the inhibitory effects of erythromycin and clarithromycin on the HERG potassium channel .
14975928	0	potassium	82,91	HERG	69,73	potassium	HERG	MESH:D011188	3757	Chemical	Gene	START_ENTITY|nsubj|characterization characterization|nmod|polymorphisms polymorphisms|nmod|END_ENTITY	Molecular and functional characterization of common polymorphisms in HERG -LRB- KCNH2 -RRB- potassium channels .
15120636	0	potassium	35,44	HERG	46,50	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channels|compound|START_ENTITY channels|appos|END_ENTITY	Potent inhibition of human cardiac potassium -LRB- HERG -RRB- channels by the anti-estrogen agent clomiphene-without QT_interval_prolongation .
15176423	0	potassium	19,28	HERG	14,18	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Modulation of HERG potassium channel function by drug action .
15326914	0	potassium	63,72	HERG	58,62	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dobj|channels	Physicochemical determinants for drug induced blockade of HERG potassium channels : effect of charge and charge shielding .
15599706	0	potassium	51,60	HERG	46,50	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dobj|channels	Class Ia anti-arrhythmic drug ajmaline blocks HERG potassium channels : mode of action .
15679475	0	potassium	80,89	HERG	74,78	potassium	HERG	MESH:D011188	3757	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|appos|END_ENTITY	Effect of beta-adrenoceptor blockers on human ether-a-go-go-related gene -LRB- HERG -RRB- potassium channels .
15720777	0	potassium	35,44	HERG	30,34	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Drug-induced block of cardiac HERG potassium channels and development of torsade_de_pointes_arrhythmias : the case of antipsychotics .
15911273	0	potassium	79,88	HERG	74,78	potassium	HERG	MESH:D011188	3757	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors .
15964935	0	potassium	67,76	HERG	62,66	potassium	HERG	MESH:D011188	3757	Chemical	Gene	START_ENTITY|nsubj|Evaluation Evaluation|nmod|method method|nmod|END_ENTITY	Evaluation of a high-throughput fluorescence assay method for HERG potassium channel inhibition .
16244363	0	potassium	51,60	HERG	46,50	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Long_QT_syndrome-associated I593R mutation in HERG potassium channel activates ER stress pathways .
16260841	0	potassium	39,48	HERG	34,38	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Coupled K + - water flux through the HERG potassium channel measured by an osmotic pulse method .
16423345	0	potassium	27,36	HERG	22,26	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Inhibition of cardiac HERG potassium channels by antidepressant maprotiline .
16711756	0	potassium	75,84	HERG	70,74	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Quantitative structure-activity relationship studies on inhibition of HERG potassium channels .
17266262	0	potassium	84,93	HERG	79,83	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Molecular dynamics and continuum electrostatics studies of inactivation in the HERG potassium channel .
17560554	0	potassium	23,32	HERG	18,22	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Inhibition of the HERG potassium channel by the tricyclic antidepressant doxepin .
18181608	0	potassium	26,35	HERG	21,25	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Incorporation of the HERG potassium channel in a mercury supported lipid bilayer .
18224703	0	potassium	83,92	HERG	9,13	potassium	HERG	MESH:D011188	3757	Chemical	Gene	simulations|compound|START_ENTITY light|nmod|simulations advances|nmod|light END_ENTITY|dep|advances	Modeling HERG and its interactions with drugs : recent advances in light of current potassium channel simulations .
18326583	0	potassium	107,116	HERG	101,105	potassium	HERG	MESH:D011188	3757	Chemical	Gene	START_ENTITY|nsubj|product product|appos|END_ENTITY	Topological mapping of the asymmetric drug binding to the human ether - - go-go-related gene product -LRB- HERG -RRB- potassium channel by use of tandem dimers .
18664324	0	potassium	77,86	HERG	72,76	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dobj|channels	Electropharmacological properties of telmisartan in blocking hKv1 .5 and HERG potassium channels expressed on Xenopus_laevis oocytes .
18923542	0	potassium	30,39	HERG	49,53	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channel|compound|START_ENTITY regulation|nmod|channel regulation|appos|END_ENTITY	The regulation of the cardiac potassium channel -LRB- HERG -RRB- by caveolin-1 .
19244476	0	potassium	30,39	HERG	25,29	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dobj|channels	State-dependent block of HERG potassium channels by R-roscovitine : implications for cancer therapy .
19528813	0	potassium	104,113	HERG	99,103	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	The organic cation transporter , OCTN1 , expressed in the human heart , potentiates antagonism of the HERG potassium channel .
19617705	0	potassium	14,23	HERG	47,51	potassium	HERG	MESH:D011188	3757	Chemical	Gene	dependency|compound|START_ENTITY dependency|nmod|block block|acl|END_ENTITY	Extracellular potassium dependency of block of HERG by quinidine and cisapride is primarily determined by the permeant ion and not by inactivation .
19765650	0	potassium	44,53	HERG	31,35	potassium	HERG	MESH:D011188	3757	Chemical	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression and significance of HERG -LRB- KCNH2 -RRB- potassium channels in the regulation of MDA-MB-435S melanoma cell proliferation and migration .
19859662	0	potassium	27,36	HERG	14,18	potassium	HERG	MESH:D011188	3757	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of HERG -LRB- KCNH2 -RRB- potassium channel surface expression by diacylglycerol .
19940115	0	potassium	49,58	HERG	44,48	potassium	HERG	MESH:D011188	2078	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Hsp40 chaperones promote degradation of the HERG potassium channel .
20104563	0	potassium	37,46	HERG	32,36	potassium	HERG	MESH:D011188	2078	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Toward a consensus model of the HERG potassium channel .
21351488	0	potassium	42,51	HERG	37,41	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|dobj|channel	-LSB- Chinfloxacin_hydrochloride inhibits HERG potassium channel at open state -RSB- .
21497594	0	potassium	48,57	HERG	43,47	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dobj|channels	Cyclovirobuxine_D inhibits the currents of HERG potassium channels stably expressed in HEK293 cells .
22039467	0	potassium	19,28	HERG	14,18	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dobj|channels	Inhibition of HERG potassium channels by celecoxib and its mechanism .
22107967	0	potassium	78,87	HERG	73,77	potassium	HERG	MESH:D011188	2078	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	The use of Bcl-2 over-expression to stabilize hybridomas specific to the HERG potassium channel .
22580281	0	potassium	23,32	HERG	18,22	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|dobj|channel	A422T mutation in HERG potassium channel retained in ER is rescurable by pharmacologic or molecular chaperones .
22586397	0	potassium	33,42	HERG	28,32	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dobj|channels	Voltage-dependent gating of HERG potassium channels .
22613764	0	potassium	73,82	HERG	68,72	potassium	HERG	MESH:D011188	3757	Chemical	Gene	synthesis|compound|START_ENTITY synthesis|compound|END_ENTITY	Mechanisms underlying the protein-kinase mediated regulation of the HERG potassium channel synthesis .
23221912	0	potassium	61,70	HERG	94,98	potassium	HERG	MESH:D011188	3757	Chemical	Gene	dependency|compound|START_ENTITY determining|dobj|dependency gate|acl|determining Role|nmod|gate Role|acl|END_ENTITY	Role of the activation gate in determining the extracellular potassium dependency of block of HERG by trapped drugs .
23313619	0	potassium	18,27	HERG	13,17	potassium	HERG	MESH:D011188	3757	Chemical	Gene	START_ENTITY|nsubj|Mechanism Mechanism|nmod|END_ENTITY	Mechanism of HERG potassium channel inhibition by tetra-n-octylammonium_bromide and benzethonium_chloride .
24154981	0	potassium	27,36	HERG	22,26	potassium	HERG	MESH:D011188	3757	Chemical	Gene	proteins|compound|START_ENTITY proteins|compound|END_ENTITY	Screening for cardiac HERG potassium channel interacting proteins using the yeast two-hybrid technique .
24846011	0	potassium	19,28	HERG	14,18	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dobj|channels	Inhibition of HERG potassium channels by domiphen_bromide and didecyl_dimethylammonium_bromide .
25418316	0	potassium	48,57	HERG	43,47	potassium	HERG	MESH:D011188	3757	Chemical	Gene	model|compound|START_ENTITY model|compound|END_ENTITY	Voltage sensor gating charge transfer in a HERG potassium channel model .
25704028	0	potassium	79,88	HERG	73,77	potassium	HERG	MESH:D011188	3757	Chemical	Gene	current|compound|START_ENTITY current|compound|END_ENTITY	Phosphatidylinositol4-phosphate_5-kinase prevents the decrease in the HERG potassium current induced by Gq protein-coupled receptor stimulation .
7604285	0	potassium	52,61	HERG	0,4	potassium	HERG	MESH:D011188	3757	Chemical	Gene	family|compound|START_ENTITY rectifier|nmod|family END_ENTITY|appos|rectifier	HERG , a human inward rectifier in the voltage-gated potassium channel family .
8587608	0	potassium	55,64	HERG	42,46	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	The inward rectification mechanism of the HERG cardiac potassium channel .
8799887	0	potassium	89,98	HERG	58,62	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|appos|channel	Molecular determinants for activation and inactivation of HERG , a human inward rectifier potassium channel .
8995352	0	potassium	41,50	HERG	36,40	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	The human delta1261 mutation of the HERG potassium channel results in a truncated protein that contains a subunit interaction domain and decreases the channel expression .
9138706	0	potassium	68,77	HERG	63,67	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	The inhibitory effect of the antipsychotic drug haloperidol on HERG potassium channels expressed in Xenopus oocytes .
9694935	0	potassium	86,95	HERG	104,108	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channel|compound|START_ENTITY channel|acl|END_ENTITY	The antipsychotic agent sertindole is a high affinity antagonist of the human cardiac potassium channel HERG .
9737994	0	potassium	5,14	HERG	0,4	potassium	HERG	MESH:D011188	3757	Chemical	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	HERG potassium channel activation is shifted by phorbol_esters via protein kinase A-dependent pathways .
9845367	0	potassium	54,63	HERG	49,53	potassium	HERG	MESH:D011188	3757	Chemical	Gene	terminus|compound|START_ENTITY terminus|compound|END_ENTITY	Crystal structure and functional analysis of the HERG potassium channel N terminus : a eukaryotic PAS domain .
9882738	0	potassium	66,75	HERG	61,65	potassium	HERG	MESH:D011188	3757	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dobj|channels	Mutations of the S4-S5 linker alter activation properties of HERG potassium channels expressed in Xenopus oocytes .
22460808	0	potassium	14,23	HERG1	8,13	potassium	HERG1	MESH:D011188	3757	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of HERG1 potassium channel in both malignant_transformation_and_disease_progression_in_head_and_neck_carcinomas .
7502075	0	potassium	14,23	HKT1	66,70	potassium	HKT1	MESH:D011188	543226(Tax:4565)	Chemical	Gene	uptake|nsubj|START_ENTITY uptake|nmod|END_ENTITY	Sodium-driven potassium uptake by the plant potassium transporter HKT1 and mutations conferring salt tolerance .
9765551	0	potassium	45,54	HKT1	23,27	potassium	HKT1	MESH:D011188	543226(Tax:4565)	Chemical	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	Rapid Up-regulation of HKT1 , a high-affinity potassium transporter gene , in roots of barley and wheat following withdrawal of potassium High-affinity K + uptake in plant roots is rapidly up-regulated when K + is withheld and down-regulated when K + is resupplied .
1547332	0	potassium	14,23	IK1	93,96	potassium	IK1	MESH:D011188	3783	Chemical	Gene	dependence|compound|START_ENTITY Origin|nmod|dependence Origin|nmod|K-current K-current|appos|END_ENTITY	Origin of the potassium and voltage dependence of the cardiac inwardly rectifying K-current -LRB- IK1 -RRB- .
15965951	0	potassium	46,55	IK1	66,69	potassium	IK1	MESH:D011188	3783	Chemical	Gene	channels|compound|START_ENTITY distribution|nmod|channels distribution|appos|END_ENTITY	Subcellular distribution of calcium-sensitive potassium channels -LRB- IK1 -RRB- in migrating cells .
17070838	0	potassium	106,115	IK1	102,105	potassium	IK1	MESH:D011188	16534(Tax:10090)	Chemical	Gene	downregulation|compound|START_ENTITY downregulation|compound|END_ENTITY	Chronic angiotensin_II stimulation in the heart produces an acquired long_QT_syndrome associated with IK1 potassium current downregulation .
21220927	0	potassium	52,61	IK1	71,74	potassium	IK1	MESH:D011188	65206(Tax:10116)	Chemical	Gene	current|compound|START_ENTITY current|appos|END_ENTITY	L-type calcium current -LRB- ICa , L -RRB- and inward rectifier potassium current -LRB- IK1 -RRB- are involved in QT_prolongation induced by arsenic_trioxide in rat .
21327545	0	potassium	49,58	IK1	68,71	potassium	IK1	MESH:D011188	65206(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Puerarin : a novel antagonist to inward rectifier potassium channel -LRB- IK1 -RRB- .
10961988	0	potassium	27,36	IKCa1	21,26	potassium	IKCa1	MESH:D011188	3783	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Up-regulation of the IKCa1 potassium channel during T-cell activation .
11425865	0	potassium	103,112	IKCa1	122,127	potassium	IKCa1	MESH:D011188	3783	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Delineation of the clotrimazole/TRAM -34 binding site on the intermediate conductance calcium-activated potassium channel , IKCa1 .
22705192	0	potassium	31,40	IKCa1	25,30	potassium	IKCa1	MESH:D011188	3783	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|compound|END_ENTITY	The effects of Kv1 .3 and IKCa1 potassium channel inhibition on calcium influx of human peripheral T lymphocytes in rheumatoid_arthritis .
24731458	0	potassium	33,42	IKCa1	27,32	potassium	IKCa1	MESH:D011188	3783	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	-LSB- Effects of telmisartan on IKCa1 potassium channel after T-lymphocyte activation and proliferation in peripheral blood of hypertensive patients in Xinjiang Kazakh -RSB- .
16297553	0	potassium	33,42	IL-6	71,75	potassium	IL-6	MESH:D011188	3569	Chemical	Gene	START_ENTITY|nmod|levels levels|nmod|END_ENTITY	Increased levels of interstitial potassium but normal levels of muscle IL-6 and LDH in patients with trapezius_myalgia .
10103089	0	potassium	162,171	IRK1	157,161	potassium	IRK1	MESH:D011188	16518(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Expression of Ras-GRF in the SK-N-BE neuroblastoma accelerates retinoic-acid-induced neuronal differentiation and increases the functional expression of the IRK1 potassium channel .
11236692	0	potassium	68,77	IRK1	87,91	potassium	IRK1	MESH:D011188	3759	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	-LSB- The blocking effects of extracellular Mn2 + on the inward rectifier potassium channel -LRB- IRK1 -RRB- -RSB- .
8603697	0	potassium	59,68	IRK1	121,125	potassium	IRK1	MESH:D011188	16518(Tax:10090)	Chemical	Gene	mRNAs|compound|START_ENTITY rectifying|dobj|mRNAs inwardly|acl|rectifying distribution|nmod|inwardly distribution|dep|comparison comparison|nmod|IRK2 IRK2|nmod|END_ENTITY	Differential distribution of classical inwardly rectifying potassium channel mRNAs in the brain : comparison of IRK2 with IRK1 and IRK3 .
8609894	0	potassium	38,47	IRK1	56,60	potassium	IRK1	MESH:D011188	3759	Chemical	Gene	channel|compound|START_ENTITY Modulation|nmod|channel END_ENTITY|nsubj|Modulation	Modulation of the inwardly rectifying potassium channel IRK1 by the m1 muscarinic receptor .
8842207	0	potassium	71,80	IRK1	91,95	potassium	IRK1	MESH:D011188	100049783(Tax:8355)	Chemical	Gene	channels|compound|START_ENTITY channels|appos|END_ENTITY	-LSB- K + -RSB- dependence of open-channel conductance in cloned inward rectifier potassium channels -LRB- IRK1 , Kir2 .1 -RRB- .
8854340	0	potassium	71,80	IRK1	91,95	potassium	IRK1	MESH:D011188	100049783(Tax:8355)	Chemical	Gene	channels|compound|START_ENTITY channels|appos|END_ENTITY	-LSB- K + -RSB- dependence of polyamine-induced rectification in inward rectifier potassium channels -LRB- IRK1 , Kir2 .1 -RRB- .
9533862	0	potassium	20,29	IRK1	71,75	potassium	IRK1	MESH:D011188	3759	Chemical	Gene	channels|compound|START_ENTITY family|nsubj|channels family|amod|END_ENTITY	Inwardly rectifying potassium channels in lens epithelium are from the IRK1 -LRB- Kir_2 .1 -RRB- family .
9758865	0	potassium	52,61	IRK1	47,51	potassium	IRK1	MESH:D011188	100049783(Tax:8355)	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Nonindependent K + movement through the pore in IRK1 potassium channels .
1939241	0	potassium	69,78	ISK	65,68	potassium	ISK	MESH:D011188	398417(Tax:8355)	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Alteration of channel activities and gating by mutations of slow ISK potassium channel .
11777323	0	potassium	55,64	Insulin	0,7	potassium	Insulin	MESH:D011188	3630	Chemical	Gene	metabolism|compound|START_ENTITY influence|nmod|metabolism influence|nsubj|END_ENTITY	Insulin and mineralocorticoids influence on extrarenal potassium metabolism in chronic hemodialysis patients .
15155829	0	potassium	76,85	Insulin	0,7	potassium	Insulin	MESH:D011188	3630	Chemical	Gene	channels|compound|START_ENTITY Ca|dep|channels activates|dobj|Ca activates|nsubj|END_ENTITY	Insulin activates native and recombinant large conductance Ca -LRB- 2 + -RRB- - activated potassium channels via a mitogen-activated protein kinase-dependent process .
15539200	0	potassium	87,96	Insulin	0,7	potassium	Insulin	MESH:D011188	105613195	Chemical	Gene	diet|compound|START_ENTITY magnesium|appos|diet fed|dobj|magnesium fed|nsubj|secretion secretion|compound|END_ENTITY	Insulin secretion and glucose_uptake in hypomagnesemic sheep fed a low magnesium , high potassium diet .
17968975	0	potassium	24,33	Insulin	0,7	potassium	Insulin	MESH:D011188	3630	Chemical	Gene	effect|nmod|START_ENTITY effect|compound|END_ENTITY	Insulin effect on serum potassium and auto-inhibition of insulin secretion is intact in a patient with leprechaunism despite severe impairment_of_substrates_metabolism .
3447811	0	potassium	27,36	Insulin	0,7	potassium	Insulin	MESH:D011188	3630	Chemical	Gene	START_ENTITY|nsubj|infusion infusion|compound|END_ENTITY	Insulin infusion and serum potassium in normal subjects .
3926504	0	potassium	54,63	Insulin	0,7	potassium	Insulin	MESH:D011188	3630	Chemical	Gene	concentration|compound|START_ENTITY fall|nmod|concentration increases|dobj|fall increases|nsubj|END_ENTITY	Insulin in vivo increases the in vitro fall of plasma potassium concentration in human venous blood .
8466068	0	potassium	28,37	Insulin	0,7	potassium	Insulin	MESH:D011188	3630	Chemical	Gene	concentration|compound|START_ENTITY decreases|dobj|concentration decreases|nsubj|END_ENTITY	Insulin decreases the serum potassium concentration during the anhepatic stage of liver transplantation .
18403443	0	potassium	61,70	Interleukin-4	0,13	potassium	Interleukin-4	MESH:D011188	3565	Chemical	Gene	channels|compound|START_ENTITY activates|dobj|channels activates|nsubj|END_ENTITY	Interleukin-4 activates large-conductance , calcium-activated potassium -LRB- BKCa -RRB- channels in human airway smooth muscle cells .
10995738	0	potassium	31,40	IsK	20,23	potassium	IsK	MESH:D011188	16509(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Contribution Contribution|nmod|END_ENTITY	Contribution of the IsK -LRB- MinK -RRB- potassium channel subunit to regulatory volume decrease in murine tracheal epithelial cells .
11414731	0	potassium	30,39	IsK	58,61	potassium	IsK	MESH:D011188	16509(Tax:10090)	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Mice disrupted for the KvLQT1 potassium channel regulator IsK gene accumulate mature T cells .
7622063	0	potassium	72,81	IsK	90,93	potassium	IsK	MESH:D011188	3753	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Gene assignment by polymerase chain reaction : localization of the human potassium channel IsK gene to the Down 's _ syndrome region of chromosome 21q22.1-q22 .2 .
7957868	0	potassium	36,45	IsK	32,35	potassium	IsK	MESH:D011188	398417(Tax:8355)	Chemical	Gene	currents|compound|START_ENTITY currents|compound|END_ENTITY	Changes in activation gating of IsK potassium currents brought about by mutations in the transmembrane sequence .
8973194	0	potassium	75,84	IsK	71,74	potassium	IsK	MESH:D011188	3753	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Peptides modeled on the transmembrane region of the slow voltage-gated IsK potassium channel : structural characterization of peptide assemblies in the beta-strand conformation .
9328483	0	potassium	102,111	IsK	0,3	potassium	IsK	MESH:D011188	3753	Chemical	Gene	channel|compound|START_ENTITY component|nmod|channel subunits|nmod|component either|nmod|subunits mutation|nmod|either cause|nsubj|mutation END_ENTITY|dep|cause	IsK and KvLQT1 : mutation in either of the two subunits of the slow component of the delayed rectifier potassium channel can cause Jervell and Lange-Nielsen_syndrome .
16380382	0	potassium	93,102	JNK	42,45	potassium	JNK	MESH:D011188	5599	Chemical	Gene	deprivation|compound|START_ENTITY induced|nmod|deprivation induced|nsubj|activation activation|nmod|END_ENTITY	N-methyl-D-aspartate blocks activation of JNK and mitochondrial apoptotic pathway induced by potassium deprivation in cerebellar granule cells .
18516069	0	potassium	36,45	K2P	31,34	potassium	K2P	MESH:D011188	51350	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|appos|END_ENTITY	Regulation of two-pore-domain -LRB- K2P -RRB- potassium leak channels by the tyrosine kinase inhibitor genistein .
19564427	0	potassium	27,36	K2P	23,26	potassium	K2P	MESH:D011188	32020(Tax:7227)	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	A structural model for K2P potassium channels based on 23 pairs of interacting sites and continuum electrostatics .
22875694	0	potassium	25,34	K2P	45,48	potassium	K2P	MESH:D011188	51350	Chemical	Gene	channels|compound|START_ENTITY channels|appos|END_ENTITY	-LSB- Cardiac two-pore-domain potassium channels -LRB- K2P -RRB- : Physiology , pharmacology , and therapeutic potential -RSB- .
23305490	0	potassium	20,29	K2P	31,34	potassium	K2P	MESH:D011188	51350	Chemical	Gene	channels|compound|START_ENTITY channels|appos|END_ENTITY	A role for two-pore potassium -LRB- K2P -RRB- channels in endometrial epithelial function .
23479219	0	potassium	48,57	K2P	44,47	potassium	K2P	MESH:D011188	51350	Chemical	Gene	TREK-1|compound|START_ENTITY TREK-1|compound|END_ENTITY	Expression and effects of modulation of the K2P potassium channels TREK-1 -LRB- KCNK2 -RRB- and TREK-2 -LRB- KCNK10 -RRB- in the normal human ovary_and_epithelial_ovarian_cancer .
23797625	0	potassium	96,105	K2P	75,78	potassium	K2P	MESH:D011188	51350	Chemical	Gene	effects|appos|START_ENTITY effects|nmod|bupivacaine bupivacaine|nmod|END_ENTITY	The inhibitory effects of bupivacaine , levobupivacaine , and ropivacaine on K2P -LRB- two-pore domain potassium -RRB- channel TREK-1 .
24116006	0	potassium	38,47	K2P	49,52	potassium	K2P	MESH:D011188	51350	Chemical	Gene	START_ENTITY|dobj|channels channels|appos|END_ENTITY	Altered expression of two-pore domain potassium -LRB- K2P -RRB- channels in cancer .
25366235	0	potassium	42,51	K2P	37,40	potassium	K2P	MESH:D011188	51350	Chemical	Gene	START_ENTITY|nsubj|sensitivity sensitivity|appos|END_ENTITY	Temperature sensitivity of two-pore -LRB- K2P -RRB- potassium channels .
25413469	0	potassium	75,84	K2P	86,89	potassium	K2P	MESH:D011188	51350	Chemical	Gene	START_ENTITY|dobj|channels channels|appos|END_ENTITY	Endocytosis as a mode to regulate functional expression of two-pore domain potassium -LRB- K2P -RRB- channels .
26993052	0	potassium	41,50	K2P	52,55	potassium	K2P	MESH:D011188	51350	Chemical	Gene	channels|compound|START_ENTITY channels|appos|END_ENTITY	Therapeutic targeting of two-pore-domain potassium -LRB- K2P -RRB- channels in the cardiovascular system .
12745922	0	potassium	26,35	KAT1	126,130	potassium	KAT1	MESH:D011188	883	Chemical	Gene	channels|compound|START_ENTITY Structure|nmod|channels Structure|dep|inferences inferences|nmod|origin origin|nmod|rectification rectification|nmod|channels channels|nummod|END_ENTITY	Structure and function of potassium channels in plants : some inferences about the molecular origin of inward rectification in KAT1 channels -LRB- Review -RRB- .
14731259	0	potassium	25,34	KAT1	52,56	potassium	KAT1	MESH:D011188	834666(Tax:3702)	Chemical	Gene	Trafficking|nmod|START_ENTITY inward|nsubj|Trafficking inward|dobj|END_ENTITY	Trafficking of the plant potassium inward rectifier KAT1 in guard cell protoplasts of Vicia faba .
16055063	0	potassium	78,87	KAT1	59,63	potassium	KAT1	MESH:D011188	856106(Tax:4932)	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	The S4 voltage sensor packs against the pore domain in the KAT1 voltage-gated potassium channel .
16263909	0	potassium	62,71	KAT1	0,4	potassium	KAT1	MESH:D011188	883	Chemical	Gene	concentrations|nmod|START_ENTITY inactivates|nmod|concentrations inactivates|nsubj|END_ENTITY	KAT1 inactivates at sub-millimolar concentrations of external potassium .
19785574	0	potassium	38,47	KAT1	33,37	potassium	KAT1	MESH:D011188	834666(Tax:3702)	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Threonine at position 306 of the KAT1 potassium channel is essential for channel activity and is a target site for ABA-activated SnRK2/OST1/SnRK2 .6 protein kinase .
23303104	0	potassium	81,90	KAT1	76,80	potassium	KAT1	MESH:D011188	834666(Tax:3702)	Chemical	Gene	channel|compound|START_ENTITY channel|nummod|END_ENTITY	Effect of counter ions on the transport current across membranes containing KAT1 potassium channel .
8966547	0	potassium	35,44	KAT1	72,76	potassium	KAT1	MESH:D011188	834666(Tax:3702)	Chemical	Gene	channel|compound|START_ENTITY Expression|nmod|channel Expression|nmod|cDNA cDNA|compound|END_ENTITY	Expression of an inward-rectifying potassium channel by the Arabidopsis KAT1 cDNA .
9635749	1	potassium	204,213	KAT1	199,203	potassium	KAT1	MESH:D011188	734936(Tax:8355)	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Functional roles of different domains -LRB- pore region , S4 segment , N-terminus -RRB- of the KAT1 potassium channel in its voltage-dependent gating were electrophysiologically studied in Xenopus oocytes .
17136396	0	potassium	31,40	KCNA1	50,55	potassium	KCNA1	MESH:D011188	378516(Tax:8355)	Chemical	Gene	channel|compound|START_ENTITY analysis|nmod|channel analysis|appos|END_ENTITY	Functional analysis of a novel potassium channel -LRB- KCNA1 -RRB- mutation in hereditary_myokymia .
17156368	0	potassium	104,113	KCNA1	40,45	potassium	KCNA1	MESH:D011188	3736	Chemical	Gene	channels|compound|START_ENTITY properties|nmod|channels impair|dobj|properties impair|nsubj|mutations mutations|nmod|gene gene|compound|END_ENTITY	Episodic_ataxia_type_1 mutations in the KCNA1 gene impair the fast inactivation properties of the human potassium channels Kv1.4-1 .1 / Kvbeta1 .1 and Kv1.4-1 .1 / Kvbeta1 .2 .
7842011	0	potassium	82,91	KCNA1	106,111	potassium	KCNA1	MESH:D011188	3736	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Episodic_ataxia / myokymia syndrome is associated with point mutations in the human potassium channel gene , KCNA1 .
21859894	0	potassium	12,21	KCNA3	36,41	potassium	KCNA3	MESH:D011188	16491(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY channels|nmod|END_ENTITY	KCNE2 forms potassium channels with KCNA3 and KCNQ1 in the choroid plexus epithelium .
11580756	0	potassium	12,21	KCNAB2	49,55	potassium	KCNAB2	MESH:D011188	8514	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Loss of the potassium channel beta-subunit gene , KCNAB2 , is associated with epilepsy in patients with 1p36 deletion syndrome .
7774931	0	potassium	54,63	KCNB1	73,78	potassium	KCNB1	MESH:D011188	3745	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Physical and genetic localization of a Shab subfamily potassium channel -LRB- KCNB1 -RRB- gene to chromosomal region 20q13 .2 .
12672015	0	potassium	30,39	KCNC1	16,21	potassium	KCNC1	MESH:D011188	423076(Tax:9031)	Chemical	Gene	START_ENTITY|nsubj|Localization Localization|nmod|END_ENTITY	Localization of KCNC1 -LRB- Kv3 .1 -RRB- potassium channel subunits in the avian auditory nucleus magnocellularis and nucleus laminaris during development .
8449507	0	potassium	41,50	KCNC1	75,80	potassium	KCNC1	MESH:D011188	3746	Chemical	Gene	gene|compound|START_ENTITY gene|appos|NGK2-KV4 NGK2-KV4|dep|END_ENTITY	Localization of a highly conserved human potassium channel gene -LRB- NGK2-KV4 ; KCNC1 -RRB- to chromosome 11p15 .
19171649	0	potassium	38,47	KCND3	32,37	potassium	KCND3	MESH:D011188	65195(Tax:10116)	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Divergent regulation of cardiac KCND3 potassium channel expression by the thyroid hormone receptors alpha1 and beta1 .
15207237	0	potassium	42,51	KCNE1	0,5	potassium	KCNE1	MESH:D011188	3753	Chemical	Gene	activity|amod|START_ENTITY regulate|dobj|activity pore|xcomp|regulate pore|nsubj|binds binds|nummod|END_ENTITY	KCNE1 binds to the KCNQ1 pore to regulate potassium channel activity .
17892302	0	potassium	90,99	KCNE1	67,72	potassium	KCNE1	MESH:D011188	3753	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|appos|channel	Preparation , functional characterization , and NMR studies of human KCNE1 , a voltage-gated potassium channel accessory subunit associated with deafness and long_QT_syndrome .
19131515	0	potassium	49,58	KCNE1	12,17	potassium	KCNE1	MESH:D011188	3753	Chemical	Gene	START_ENTITY|nsubj|Location Location|nmod|END_ENTITY	Location of KCNE1 relative to KCNQ1 in the I -LRB- KS -RRB- potassium channel by disulfide cross-linking of substituted cysteines .
21296569	0	potassium	73,82	KCNE1	43,48	potassium	KCNE1	MESH:D011188	3753	Chemical	Gene	channel|compound|START_ENTITY model|nmod|channel model|nmod|basis basis|nmod|modulation modulation|compound|END_ENTITY	Working model for the structural basis for KCNE1 modulation of the KCNQ1 potassium channel .
21943416	0	potassium	78,87	KCNE1	0,5	potassium	KCNE1	MESH:D011188	3753	Chemical	Gene	channels|compound|START_ENTITY trafficking|nmod|channels inhibit|dobj|trafficking inhibit|nsubj|END_ENTITY	KCNE1 and KCNE2 inhibit forward trafficking of homomeric N-type voltage-gated potassium channels .
21943417	0	potassium	61,70	KCNE1	0,5	potassium	KCNE1	MESH:D011188	3753	Chemical	Gene	composition|compound|START_ENTITY governing|dobj|composition provide|dep|governing provide|nsubj|END_ENTITY	KCNE1 and KCNE2 provide a checkpoint governing voltage-gated potassium channel a-subunit composition .
22771213	0	potassium	34,43	KCNE1	9,14	potassium	KCNE1	MESH:D011188	3753	Chemical	Gene	channel|compound|START_ENTITY regulate|dobj|channel regulate|nsubj|END_ENTITY	How does KCNE1 regulate the Kv7 .1 potassium channel ?
23213782	0	potassium	31,40	KCNE1	15,20	potassium	KCNE1	MESH:D011188	3753	Chemical	Gene	channels|compound|START_ENTITY channels|amod|-LSB- -LSB-|dep|KCNQ1 KCNQ1|nummod|END_ENTITY	-LSB- KCNQ1 , KCNH2 , KCNE1 and KCNE2 potassium channels gene variants in sudden_manhood_death_syndrome -RSB- .
24400172	0	potassium	43,52	KCNE1	16,21	potassium	KCNE1	MESH:D011188	3753	Chemical	Gene	response|compound|START_ENTITY variants|nmod|response variants|nummod|END_ENTITY	Modification by KCNE1 variants of the hERG potassium channel response to premature stimulation and to pharmacological inhibition .
11034315	0	potassium	19,28	KCNE2	59,64	potassium	KCNE2	MESH:D011188	9992	Chemical	Gene	channels|compound|START_ENTITY modulated|nsubjpass|channels modulated|nmod|subunit subunit|compound|END_ENTITY	M-type KCNQ2-KCNQ3 potassium channels are modulated by the KCNE2 subunit .
11101505	0	potassium	70,79	KCNE2	0,5	potassium	KCNE2	MESH:D011188	9992	Chemical	Gene	channel|compound|START_ENTITY confers|nmod|channel confers|nsubj|END_ENTITY	KCNE2 confers background current characteristics to the cardiac KCNQ1 potassium channel .
11278781	0	potassium	61,70	KCNE2	101,106	potassium	KCNE2	MESH:D011188	9992	Chemical	Gene	channel|compound|START_ENTITY domain|nmod|channel Analysis|nmod|domain Analysis|nmod|END_ENTITY	Analysis of the cyclic nucleotide binding domain of the HERG potassium channel and interactions with KCNE2 .
15368194	4	potassium	499,508	KCNE2	539,544	potassium	KCNE2	MESH:D011188	9992	Chemical	Gene	channels|compound|START_ENTITY channels|dep|KCNE5 KCNE5|appos|END_ENTITY	We evaluated 28 unrelated Chinese kindreds with AF and sequenced eight genes of potassium channels -LRB- KCNQ1 , HERG , KCNE1 , KCNE2 , KCNE3 , KCNE4 , KCNE5 , and KCNJ2 -RRB- .
16754665	0	potassium	10,19	KCNE2	4,9	potassium	KCNE2	MESH:D011188	246133(Tax:10090)	Chemical	Gene	subunit|amod|START_ENTITY subunit|compound|END_ENTITY	The KCNE2 potassium channel ancillary subunit is essential for gastric_acid secretion .
21859894	0	potassium	12,21	KCNE2	0,5	potassium	KCNE2	MESH:D011188	246133(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY forms|dobj|channels forms|nsubj|END_ENTITY	KCNE2 forms potassium channels with KCNA3 and KCNQ1 in the choroid plexus epithelium .
12414843	0	potassium	24,33	KCNE3	18,23	potassium	KCNE3	MESH:D011188	10008	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	A mutation in the KCNE3 potassium channel gene is associated with susceptibility to thyrotoxic_hypokalemic periodic paralysis .
15212652	0	potassium	25,34	KCNE3	19,24	potassium	KCNE3	MESH:D011188	10008	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	No mutation in the KCNE3 potassium channel gene in Chinese thyrotoxic_hypokalaemic periodic paralysis patients .
16782062	0	potassium	44,53	KCNE3	0,5	potassium	KCNE3	MESH:D011188	10008	Chemical	Gene	channel|compound|START_ENTITY subunit|nmod|channel subunit|nsubj|END_ENTITY	KCNE3 is an inhibitory subunit of the Kv4 .3 potassium channel .
19306396	0	potassium	42,51	KCNE3	6,11	potassium	KCNE3	MESH:D011188	10008	Chemical	Gene	repolarizing|dobj|START_ENTITY reduces|xcomp|repolarizing reduces|nsubj|mutation mutation|compound|END_ENTITY	Novel KCNE3 mutation reduces repolarizing potassium current and associated with long_QT_syndrome .
21899751	0	potassium	39,48	KCNE3	65,70	potassium	KCNE3	MESH:D011188	10008	Chemical	Gene	channel|compound|START_ENTITY resequencing|nmod|channel subunit|nsubj|resequencing subunit|dobj|gene gene|nummod|END_ENTITY	Deep resequencing of the voltage-gated potassium channel subunit KCNE3 gene in chronic tinnitus .
22310694	0	potassium	64,73	KCNH1	58,63	potassium	KCNH1	MESH:D011188	3756	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Cysteines control the N - and C-linker-dependent gating of KCNH1 potassium channels .
24062569	0	potassium	6,15	KCNH1	0,5	potassium	KCNH1	MESH:D011188	3756	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	KCNH1 potassium channels are expressed in cervical cytologies from pregnant patients and are regulated by progesterone .
25711872	0	potassium	44,53	KCNH1	67,72	potassium	KCNH1	MESH:D011188	3756	Chemical	Gene	Temple-Baraitser_syndrome|compound|START_ENTITY Temple-Baraitser_syndrome|nummod|END_ENTITY	Corrigendum : Mutations in the voltage-gated potassium channel gene KCNH1 cause Temple-Baraitser_syndrome and epilepsy .
14975928	0	potassium	82,91	KCNH2	75,80	potassium	KCNH2	MESH:D011188	3757	Chemical	Gene	START_ENTITY|nsubj|characterization characterization|appos|END_ENTITY	Molecular and functional characterization of common polymorphisms in HERG -LRB- KCNH2 -RRB- potassium channels .
16227340	0	potassium	59,68	KCNH2	45,50	potassium	KCNH2	MESH:D011188	3757	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dep|channels	Specific serine proteases selectively damage KCNH2 -LRB- hERG1 -RRB- potassium channels and I -LRB- Kr -RRB- .
18948620	0	potassium	39,48	KCNH2	32,37	potassium	KCNH2	MESH:D011188	16511(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|hERG hERG|appos|END_ENTITY	Homozygous missense N629D hERG -LRB- KCNH2 -RRB- potassium channel mutation causes developmental_defects in the right ventricle and its outflow tract and embryonic_lethality .
19765650	0	potassium	44,53	KCNH2	37,42	potassium	KCNH2	MESH:D011188	3757	Chemical	Gene	START_ENTITY|nsubj|Expression Expression|appos|END_ENTITY	Expression and significance of HERG -LRB- KCNH2 -RRB- potassium channels in the regulation of MDA-MB-435S melanoma cell proliferation and migration .
19859662	0	potassium	27,36	KCNH2	20,25	potassium	KCNH2	MESH:D011188	3757	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|appos|END_ENTITY	Regulation of HERG -LRB- KCNH2 -RRB- potassium channel surface expression by diacylglycerol .
20507645	0	potassium	62,71	KCNH2	92,97	potassium	KCNH2	MESH:D011188	3757	Chemical	Gene	HERG1|amod|START_ENTITY HERG1|appos|END_ENTITY	Two four-marker haplotypes on 7q36 .1 region indicate that the potassium channel gene HERG1 -LRB- KCNH2 , Kv11 .1 -RRB- is related to schizophrenia : a case control study .
22573844	0	potassium	123,132	KCNH2	142,147	potassium	KCNH2	MESH:D011188	3757	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Structure-guided topographic mapping and mutagenesis to elucidate binding sites for the human ether-a-go-go-related gene 1 potassium channel -LRB- KCNH2 -RRB- activator NS1643 .
23213782	0	potassium	31,40	KCNH2	8,13	potassium	KCNH2	MESH:D011188	3757	Chemical	Gene	channels|compound|START_ENTITY channels|amod|-LSB- -LSB-|dep|KCNQ1 KCNQ1|nummod|END_ENTITY	-LSB- KCNQ1 , KCNH2 , KCNE1 and KCNE2 potassium channels gene variants in sudden_manhood_death_syndrome -RSB- .
25800797	0	potassium	81,90	KCNH2	68,73	potassium	KCNH2	MESH:D011188	403761(Tax:9615)	Chemical	Gene	channels|compound|START_ENTITY mediated|dobj|channels mediated|nmod|END_ENTITY	Hypaconitine-induced QT_prolongation mediated through inhibition of KCNH2 -LRB- hERG -RRB- potassium channels in conscious dogs .
12890647	0	potassium	61,70	KCNH8	48,53	potassium	KCNH8	MESH:D011188	131096	Chemical	Gene	START_ENTITY|nsubj|properties properties|nmod|END_ENTITY	Distribution and functional properties of human KCNH8 -LRB- Elk1 -RRB- potassium channels .
11795013	0	potassium	135,144	KCNJ1	76,81	potassium	KCNJ1	MESH:D011188	3758	Chemical	Gene	-RSB-|compound|START_ENTITY synthesis|nmod|-RSB- codifies|dobj|synthesis detection|acl:relcl|codifies detection|nmod|mutation mutation|nmod|gene gene|compound|END_ENTITY	-LSB- Neonatal Bartter disease diagnosed with the detection of a mutation of the KCNJ1 gene which codifies the synthesis of the renal ROMK1 potassium channel -RSB- .
9099852	0	potassium	48,57	KCNJ1	42,47	potassium	KCNJ1	MESH:D011188	3758	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Nucleotide sequence analysis of the human KCNJ1 potassium channel locus .
15120748	0	potassium	50,59	KCNJ10	43,49	potassium	KCNJ10	MESH:D011188	3766	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Association between variation in the human KCNJ10 potassium ion channel gene and seizure susceptibility .
15725393	0	potassium	67,76	KCNJ10	60,66	potassium	KCNJ10	MESH:D011188	3766	Chemical	Gene	START_ENTITY|nsubj|evidence evidence|nmod|association association|nmod|END_ENTITY	Supportive evidence for an allelic association of the human KCNJ10 potassium channel gene with idiopathic_generalized_epilepsy .
15936844	0	potassium	65,74	KCNJ10	84,90	potassium	KCNJ10	MESH:D011188	3766	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Functional characterisation of missense variations in the Kir4 .1 potassium channel -LRB- KCNJ10 -RRB- associated with seizure susceptibility .
16925593	0	potassium	28,37	KCNJ10	47,53	potassium	KCNJ10	MESH:D011188	16513(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Progressive loss of a glial potassium channel -LRB- KCNJ10 -RRB- in the spinal cord of the SOD1 -LRB- G93A -RRB- transgenic mouse model of amyotrophic_lateral_sclerosis .
21763485	0	potassium	63,72	KCNJ13	23,29	potassium	KCNJ13	MESH:D011188	3769	Chemical	Gene	subunit|compound|START_ENTITY encoding|dobj|subunit cause|advcl|encoding cause|nsubj|mutations mutations|nmod|END_ENTITY	Recessive mutations in KCNJ13 , encoding an inwardly rectifying potassium channel subunit , cause leber_congenital_amaurosis .
9299242	0	potassium	23,32	KCNJ15	47,53	potassium	KCNJ15	MESH:D011188	3772	Chemical	Gene	START_ENTITY|dobj|gene gene|appos|END_ENTITY	A new inward rectifier potassium channel gene -LRB- KCNJ15 -RRB- localized on chromosome 21 in the Down syndrome chromosome region 1 -LRB- DCR1 -RRB- .
25777558	0	potassium	40,49	KCNJ2	66,71	potassium	KCNJ2	MESH:D011188	3759	Chemical	Gene	Kir2|compound|START_ENTITY Upregulation|nmod|Kir2 Upregulation|appos|END_ENTITY	Upregulation of the inwardly rectifying potassium channel Kir2 .1 -LRB- KCNJ2 -RRB- modulates multidrug resistance of small-cell_lung_cancer under the regulation of miR-7 and the Ras/MAPK pathway .
25880778	0	potassium	40,49	KCNJ2	66,71	potassium	KCNJ2	MESH:D011188	3759	Chemical	Gene	Kir2|compound|START_ENTITY Upregulation|nmod|Kir2 Upregulation|appos|END_ENTITY	Upregulation of the inwardly rectifying potassium channel Kir2 .1 -LRB- KCNJ2 -RRB- modulates multidrug resistance of small-cell_lung_cancer under the regulation of miR-7 and the Ras/MAPK pathway .
25880778	0	potassium	40,49	KCNJ2	66,71	potassium	KCNJ2	MESH:D011188	3759	Chemical	Gene	Kir2|compound|START_ENTITY Upregulation|nmod|Kir2 Upregulation|appos|END_ENTITY	Upregulation of the inwardly rectifying potassium channel Kir2 .1 -LRB- KCNJ2 -RRB- modulates multidrug resistance of small-cell_lung_cancer under the regulation of miR-7 and the Ras/MAPK pathway .
9712915	0	potassium	72,81	KCNJ2	96,101	potassium	KCNJ2	MESH:D011188	16518(Tax:10090)	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Multiple promoter elements interact to control the transcription of the potassium channel gene , KCNJ2 .
9778459	0	potassium	100,109	KCNJ2	73,78	potassium	KCNJ2	MESH:D011188	3759	Chemical	Gene	gene|amod|START_ENTITY rectifying|dobj|gene inwardly|xcomp|rectifying inwardly|nsubj|Detection Detection|appos|END_ENTITY	Detection of a high-frequency silent polymorphism -LRB- C -- > T -RRB- in the kir2 .1 -LRB- KCNJ2 -RRB- inwardly rectifying potassium channel gene by polymerase chain reaction and single strand conformation polymorphism .
8088798	0	potassium	44,53	KCNJ3	76,81	potassium	KCNJ3	MESH:D011188	3760	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Human G-protein-coupled inwardly rectifying potassium channel -LRB- GIRK1 -RRB- gene -LRB- KCNJ3 -RRB- : localization to chromosome 2 and identification of a simple tandem repeat polymorphism .
22848660	0	potassium	115,124	KCNJ5	109,114	potassium	KCNJ5	MESH:D011188	3762	Chemical	Gene	filter|compound|START_ENTITY filter|compound|END_ENTITY	Comprehensive re-sequencing of adrenal aldosterone producing lesions reveal three somatic mutations near the KCNJ5 potassium channel selectivity filter .
23829355	0	potassium	61,70	KCNJ5	54,59	potassium	KCNJ5	MESH:D011188	3762	Chemical	Gene	channel|compound|START_ENTITY channel|amod|.4 .4|dep|END_ENTITY	Regulation of aldosterone biosynthesis by the Kir3 .4 -LRB- KCNJ5 -RRB- potassium channel .
24420545	0	potassium	94,103	KCNJ5	88,93	potassium	KCNJ5	MESH:D011188	3762	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Role for germline mutations and a rare coding single nucleotide polymorphism within the KCNJ5 potassium channel in a large cohort of sporadic cases of primary_aldosteronism .
22846993	0	potassium	41,50	KCNK3	65,70	potassium	KCNK3	MESH:D011188	3777	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	The acid-sensitive , anesthetic-activated potassium leak channel , KCNK3 , is regulated by 14-3-3b-dependent , protein kinase C -LRB- PKC -RRB- - mediated endocytic trafficking .
23460565	0	potassium	46,55	KCNK3	8,13	potassium	KCNK3	MESH:D011188	29553(Tax:10116)	Chemical	Gene	antagonists|compound|START_ENTITY stimulate|nsubj|antagonists pore|ccomp|stimulate pore|nsubj|TASK-1 TASK-1|appos|END_ENTITY	TASK-1 -LRB- KCNK3 -RRB- and TASK-3 -LRB- KCNK9 -RRB- tandem pore potassium channel antagonists stimulate breathing in isoflurane-anesthetized rats .
12707131	0	potassium	28,37	KCNK5	12,17	potassium	KCNK5	MESH:D011188	16529(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Mutation of KCNK5 or Kir3 .2 potassium channels in mice does not change minimum alveolar anesthetic concentration .
12676587	0	potassium	60,69	KCNK9	54,59	potassium	KCNK9	MESH:D011188	51305	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene .
17704508	0	potassium	92,101	KCNK9	86,91	potassium	KCNK9	MESH:D011188	223604(Tax:10090)	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Sequence-based bioinformatic prediction and QUASEP identify genomic imprinting of the KCNK9 potassium channel gene in mouse and human .
20646278	0	potassium	16,25	KCNK9	83,88	potassium	KCNK9	MESH:D011188	223604(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY channels|dep|focus focus|nmod|.1 .1|appos|TASK3 TASK3|dep|END_ENTITY	Two pore domain potassium channels in cerebral_ischemia : a focus on K2P9 .1 -LRB- TASK3 , KCNK9 -RRB- .
22147752	0	potassium	100,109	KCNK9	81,86	potassium	KCNK9	MESH:D011188	84429(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|amod|TASK-3 TASK-3|dep|END_ENTITY	Covalent modification of a volatile anesthetic regulatory site activates TASK-3 -LRB- KCNK9 -RRB- tandem-pore potassium channels .
23658958	0	potassium	137,146	KCNK9	82,87	potassium	KCNK9	MESH:D011188	51305	Chemical	Gene	channel|compound|START_ENTITY inhibitor|nmod|channel identified|nmod|inhibitor identified|nsubjpass|ML308 ML308|compound|END_ENTITY	Development of a Selective Chemical Inhibitor for the Two-Pore Potassium Channel , KCNK9 ML308 was identified as a novel inhibitor of the potassium channel , subfamily K , member 9 -LRB- KCNK9 -RRB- two-pore domain potassium channel .
23658958	0	potassium	202,211	KCNK9	82,87	potassium	KCNK9	MESH:D011188	51305	Chemical	Gene	channel|compound|START_ENTITY member|dep|channel K|appos|member subfamily|dobj|K subfamily|parataxis|identified identified|nsubjpass|ML308 ML308|compound|END_ENTITY	Development of a Selective Chemical Inhibitor for the Two-Pore Potassium Channel , KCNK9 ML308 was identified as a novel inhibitor of the potassium channel , subfamily K , member 9 -LRB- KCNK9 -RRB- two-pore domain potassium channel .
25318378	0	potassium	20,29	KCNK9	14,19	potassium	KCNK9	MESH:D011188	51305	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Silencing the KCNK9 potassium channel -LRB- TASK-3 -RRB- gene disturbs mitochondrial function , causes mitochondrial depolarization , and induces apoptosis of human melanoma cells .
18854754	0	potassium	32,41	KCNMA1	25,31	potassium	KCNMA1	MESH:D011188	3778	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Genetic variation in the KCNMA1 potassium channel alpha subunit as risk factor for severe essential hypertension and myocardial_infarction .
15057310	0	potassium	40,49	KCNMB1	33,39	potassium	KCNMB1	MESH:D011188	3779	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	Gain-of-function mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic_hypertension .
10516439	0	potassium	87,96	KCNN1	115,120	potassium	KCNN1	MESH:D011188	3780	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Gene structure and chromosome mapping of the human small-conductance calcium-activated potassium channel SK1 gene -LRB- KCNN1 -RRB- .
10196711	0	potassium	46,55	KCNN3	31,36	potassium	KCNN3	MESH:D011188	3782	Chemical	Gene	START_ENTITY|nsubj|evidence evidence|nmod|involvement involvement|nmod|END_ENTITY	No evidence for involvement of KCNN3 -LRB- hSKCa3 -RRB- potassium channel gene in familial and isolated cases of schizophrenia .
10395218	0	potassium	82,91	KCNN3	101,106	potassium	KCNN3	MESH:D011188	3782	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Genetic association study of a polymorphic CAG repeats array of calcium-activated potassium channel -LRB- KCNN3 -RRB- gene and schizophrenia among the Chinese population from Taiwan .
15705118	0	potassium	51,60	KCNN3	69,74	potassium	KCNN3	MESH:D011188	3782	Chemical	Gene	channel|compound|START_ENTITY stretch|nmod|channel END_ENTITY|nsubj|stretch	A highly polymorphic poly-glutamine stretch in the potassium channel KCNN3 in migraine .
16162291	0	potassium	69,78	KCNN3	92,97	potassium	KCNN3	MESH:D011188	3782	Chemical	Gene	gene|compound|START_ENTITY Repeat|nmod|gene analysis|nmod|Repeat END_ENTITY|nsubj|analysis	Association analysis of a highly polymorphic CAG Repeat in the human potassium channel gene KCNN3 and migraine susceptibility .
16393881	0	potassium	69,78	KCNN3	88,93	potassium	KCNN3	MESH:D011188	3782	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Schizophrenia and polymorphic CAG repeats array of calcium-activated potassium channel -LRB- KCNN3 -RRB- gene in Serbian population .
22030984	0	potassium	22,31	KCNN3	46,51	potassium	KCNN3	MESH:D011188	3782	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Variants in the human potassium channel gene -LRB- KCNN3 -RRB- are associated with migraine in a high risk genetic isolate .
15148241	0	potassium	80,89	KCNN4	74,79	potassium	KCNN4	MESH:D011188	3783	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	4-Chloro-benzo -LSB- F -RSB- isoquinoline -LRB- CBIQ -RRB- activates CFTR chloride channels and KCNN4 potassium channels in Calu-3 human airway epithelial cells .
15379997	0	potassium	60,69	KCNN4	79,84	potassium	KCNN4	MESH:D011188	65206(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Selective intermediate - / small-conductance calcium-activated potassium channel -LRB- KCNN4 -RRB- blockers are potent and effective therapeutics in experimental brain_oedema and traumatic brain_injury caused by acute_subdural_haematoma .
17360457	0	potassium	5,14	KCNQ	0,4	potassium	KCNQ	MESH:D011188	36071(Tax:7227)	Chemical	Gene	mutations|compound|START_ENTITY mutations|amod|END_ENTITY	KCNQ potassium channel mutations cause cardiac_arrhythmias in Drosophila that mimic the effects of aging .
10646604	0	potassium	22,31	KCNQ1	50,55	potassium	KCNQ1	MESH:D011188	3784	Chemical	Gene	channel|compound|START_ENTITY formed|nsubj|channel formed|nmod|END_ENTITY	A constitutively open potassium channel formed by KCNQ1 and KCNE3 .
11101505	0	potassium	70,79	KCNQ1	64,69	potassium	KCNQ1	MESH:D011188	3784	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	KCNE2 confers background current characteristics to the cardiac KCNQ1 potassium channel .
11761407	0	potassium	59,68	KCNQ1	53,58	potassium	KCNQ1	MESH:D011188	3784	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Evidence for a single nucleotide polymorphism in the KCNQ1 potassium channel that underlies susceptibility to life-threatening arrhythmias .
12710526	0	potassium	59,68	KCNQ1	53,58	potassium	KCNQ1	MESH:D011188	3784	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Biophysical characteristics of a new mutation on the KCNQ1 potassium channel -LRB- L251P -RRB- causing long_QT_syndrome .
14561821	0	potassium	71,80	KCNQ1	65,70	potassium	KCNQ1	MESH:D011188	3784	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Tight coupling of rubidium conductance and inactivation in human KCNQ1 potassium channels .
14576198	0	potassium	76,85	KCNQ1	70,75	potassium	KCNQ1	MESH:D011188	373746(Tax:8355)	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Pharmacological activation of normal and arrhythmia-associated mutant KCNQ1 potassium channels .
15207237	0	potassium	42,51	KCNQ1	19,24	potassium	KCNQ1	MESH:D011188	3784	Chemical	Gene	activity|amod|START_ENTITY regulate|dobj|activity pore|xcomp|regulate pore|nsubj|binds binds|nmod|END_ENTITY	KCNE1 binds to the KCNQ1 pore to regulate potassium channel activity .
15226366	0	potassium	44,53	KCNQ1	38,43	potassium	KCNQ1	MESH:D011188	3784	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	External barium affects the gating of KCNQ1 potassium channels and produces a pore block via two discrete sites .
15316073	0	potassium	34,43	KCNQ1	28,33	potassium	KCNQ1	MESH:D011188	483669(Tax:9615)	Chemical	Gene	channels|compound|START_ENTITY channels|nummod|END_ENTITY	Basolateral localisation of KCNQ1 potassium channels in MDCK cells : molecular identification of an N-terminal targeting motif .
16287990	0	potassium	10,19	KCNQ1	4,9	potassium	KCNQ1	MESH:D011188	3784	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	The KCNQ1 potassium channel : from gene to physiological function .
16581021	0	potassium	50,59	KCNQ1	34,39	potassium	KCNQ1	MESH:D011188	100379230(Tax:10141)	Chemical	Gene	START_ENTITY|nsubj|modulation modulation|nmod|END_ENTITY	Frequency-dependent modulation of KCNQ1 and HERG1 potassium channels .
16831322	0	potassium	20,29	KCNQ1	38,43	potassium	KCNQ1	MESH:D011188	3784	Chemical	Gene	S145L|compound|START_ENTITY S145L|compound|END_ENTITY	-LSB- Novel mutations of potassium channel KCNQ1 S145L and KCNH2 Y475C genes in Chinese pedigrees of long_QT_syndrome -RSB- .
16887873	0	potassium	104,113	KCNQ1	98,103	potassium	KCNQ1	MESH:D011188	373746(Tax:8355)	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Ancillary subunits and stimulation frequency determine the potency of chromanol 293B block of the KCNQ1 potassium channel .
17227916	0	potassium	74,83	KCNQ1	68,73	potassium	KCNQ1	MESH:D011188	3784	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|charges charges|nmod|END_ENTITY	The role of S4 charges in voltage-dependent and voltage-independent KCNQ1 potassium channel complexes .
17289006	0	potassium	10,19	KCNQ1	4,9	potassium	KCNQ1	MESH:D011188	3784	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	The KCNQ1 potassium channel is down-regulated by ubiquitylating enzymes of the Nedd4/Nedd4-like family .
17310097	0	potassium	53,62	KCNQ1	47,52	potassium	KCNQ1	MESH:D011188	3784	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	KCNE beta subunits determine pH sensitivity of KCNQ1 potassium channels .
17347319	0	potassium	92,101	KCNQ1	26,31	potassium	KCNQ1	MESH:D011188	3784	Chemical	Gene	ion|compound|START_ENTITY involves|nmod|ion involves|nsubj|channels channels|amod|binding binding|nmod|END_ENTITY	Chromanol 293B binding in KCNQ1 -LRB- Kv7 .1 -RRB- channels involves electrostatic interactions with a potassium ion in the selectivity filter .
17704175	0	potassium	56,65	KCNQ1	50,55	potassium	KCNQ1	MESH:D011188	3784	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	An inactivation gate in the selectivity filter of KCNQ1 potassium channels .
17999538	0	potassium	46,55	KCNQ1	26,31	potassium	KCNQ1	MESH:D011188	3784	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Structural models for the KCNQ1 voltage-gated potassium channel .
18266681	0	potassium	68,77	KCNQ1	62,67	potassium	KCNQ1	MESH:D011188	3784	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	A double-point mutation in the selectivity filter site of the KCNQ1 potassium channel results in a severe phenotype , LQT1 , of long_QT_syndrome .
18490447	0	potassium	130,139	KCNQ1	124,129	potassium	KCNQ1	MESH:D011188	3784	Chemical	Gene	channels|compound|START_ENTITY channels|nummod|END_ENTITY	Desensitization of chemical activation by auxiliary subunits : convergence of molecular determinants critical for augmenting KCNQ1 potassium channels .
18590565	0	potassium	54,63	KCNQ1	25,30	potassium	KCNQ1	MESH:D011188	3784	Chemical	Gene	sequences|compound|START_ENTITY sequences|compound|END_ENTITY	Evolutionary analyses of KCNQ1 and HERG voltage-gated potassium channel sequences reveal location-specific susceptibility and augmented chemical severities of arrhythmogenic mutations .
18611041	0	potassium	67,76	KCNQ1	61,66	potassium	KCNQ1	MESH:D011188	3784	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Structure of KCNE1 and implications for how it modulates the KCNQ1 potassium channel .
19131515	0	potassium	49,58	KCNQ1	30,35	potassium	KCNQ1	MESH:D011188	3784	Chemical	Gene	START_ENTITY|advmod|relative relative|nmod|END_ENTITY	Location of KCNE1 relative to KCNQ1 in the I -LRB- KS -RRB- potassium channel by disulfide cross-linking of substituted cysteines .
19198868	0	potassium	74,83	KCNQ1	60,65	potassium	KCNQ1	MESH:D011188	16535(Tax:10090)	Chemical	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Identification of an ethnic-specific variant -LRB- V207M -RRB- of the KCNQ1 cardiac potassium channel gene in sudden unexplained death and implications from a knock-in mouse model .
19940153	0	potassium	39,48	KCNQ1	33,38	potassium	KCNQ1	MESH:D011188	3784	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Direct observation of individual KCNQ1 potassium channels reveals their distinctive diffusive behavior .
21296569	0	potassium	73,82	KCNQ1	67,72	potassium	KCNE1	MESH:D011188	3753	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Working model for the structural basis for KCNE1 modulation of the KCNQ1 potassium channel .
21594822	0	potassium	44,53	KCNQ1	20,25	potassium	KCNQ1	MESH:D011188	3784	Chemical	Gene	encoding|dobj|START_ENTITY encoding|nsubj|END_ENTITY	Expression of genes KCNQ1 and HERG encoding potassium ion channels Ikr , Iks in long_QT_syndrome .
22024150	0	potassium	82,91	KCNQ1	76,81	potassium	KCNQ1	MESH:D011188	3784	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels .
22189896	0	potassium	81,90	KCNQ1	129,134	potassium	KCNQ1	MESH:D011188	3784	Chemical	Gene	current|compound|START_ENTITY component|nmod|current decreases|dobj|component decreases|nmod|cells cells|acl|transfected transfected|nmod|END_ENTITY	Chronic probucol treatment decreases the slow component of the delayed-rectifier potassium current in CHO cells transfected with KCNQ1 and KCNE1 : a novel mechanism of QT_prolongation .
22509038	0	potassium	67,76	KCNQ1	61,66	potassium	KCNQ1	MESH:D011188	3784	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Allosteric gating mechanism underlies the flexible gating of KCNQ1 potassium channels .
22745159	0	potassium	114,123	KCNQ1	108,113	potassium	KCNQ1	MESH:D011188	3784	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Modulation of hERG potassium channel gating normalizes action potential duration prolonged by dysfunctional KCNQ1 potassium channel .
22745159	0	potassium	19,28	KCNQ1	108,113	potassium	KCNQ1	MESH:D011188	3784	Chemical	Gene	channel|compound|START_ENTITY Modulation|nmod|channel normalizes|nsubj|Modulation normalizes|dobj|duration duration|amod|prolonged prolonged|nmod|channel channel|compound|END_ENTITY	Modulation of hERG potassium channel gating normalizes action potential duration prolonged by dysfunctional KCNQ1 potassium channel .
22910039	0	potassium	147,156	KCNQ1	140,145	potassium	KCNQ1	MESH:D011188	3784	Chemical	Gene	START_ENTITY|nsubj|Identification Identification|appos|END_ENTITY	Identification of -LRB- R -RRB- - N - -LRB- 4 - -LRB- 4-methoxyphenyl -RRB- thiazol-2-yl -RRB- -1 - tosylpiperidine-2-carboxamide , ML277 , as a novel , potent and selective K -LRB- v -RRB- 7.1 -LRB- KCNQ1 -RRB- potassium channel activator .
23213782	0	potassium	31,40	KCNQ1	1,6	potassium	KCNQ1	MESH:D011188	3784	Chemical	Gene	channels|compound|START_ENTITY channels|amod|-LSB- -LSB-|dep|END_ENTITY	-LSB- KCNQ1 , KCNH2 , KCNE1 and KCNE2 potassium channels gene variants in sudden_manhood_death_syndrome -RSB- .
23529131	0	potassium	25,34	KCNQ1	19,24	potassium	KCNQ1	MESH:D011188	84020(Tax:10116)	Chemical	Gene	endocytosis|compound|START_ENTITY endocytosis|nummod|END_ENTITY	Oestrogen promotes KCNQ1 potassium channel endocytosis and postendocytic trafficking in colonic epithelium .
23762928	0	potassium	89,98	KCNQ1	55,60	potassium	KCNQ1	MESH:D011188	3784	Chemical	Gene	channels|compound|START_ENTITY channels|amod|KCNQ KCNQ|nmod:npmod|channels channels|nummod|END_ENTITY	Identification of a novel , small molecule activator of KCNQ1 channels KCNQ voltage-gated potassium channels are involved in regulating excitability , action potential duration and transport processes in a variety of cell types .
24606221	0	potassium	82,91	KCNQ1	76,81	potassium	KCNQ1	MESH:D011188	3784	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Purification and structural study of the voltage-sensor domain of the human KCNQ1 potassium ion channel .
25475720	0	potassium	59,68	KCNQ1	53,58	potassium	KCNQ1	MESH:D011188	3784	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Structural analysis of the S4-S5 linker of the human KCNQ1 potassium channel .
11230508	0	potassium	30,39	KCNQ2	24,29	potassium	KCNQ2	MESH:D011188	170848(Tax:10116)	Chemical	Gene	transcripts|compound|START_ENTITY transcripts|compound|END_ENTITY	Alternative splicing of KCNQ2 potassium channel transcripts contributes to the functional diversity of M-currents .
11726784	0	potassium	43,52	KCNQ2	61,66	potassium	KCNQ2	MESH:D011188	3785	Chemical	Gene	channel|compound|START_ENTITY analysis|nmod|channel END_ENTITY|nsubj|analysis	Cloning and mutation analysis of the human potassium channel KCNQ2 gene promoter .
12395102	0	potassium	18,27	KCNQ2	36,41	potassium	KCNQ2	MESH:D011188	3785	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|nsubj|channel	The voltage-gated potassium channel KCNQ2 in Taiwanese children with febrile convulsions .
12871719	0	potassium	46,55	KCNQ2	40,45	potassium	KCNQ2	MESH:D011188	3785	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	A medium-throughput functional assay of KCNQ2 potassium channels using rubidium efflux and atomic absorption spectrometry .
14534157	0	potassium	16,25	KCNQ2	0,5	potassium	KCNQ2	MESH:D011188	3785	Chemical	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	KCNQ2 and KCNQ3 potassium channel genes in benign_familial_neonatal_convulsions : expansion of the functional and mutation spectrum .
15030501	0	potassium	64,73	KCNQ2	58,63	potassium	KCNQ2	MESH:D011188	3785	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Complete loss of the cytoplasmic carboxyl terminus of the KCNQ2 potassium channel : a novel mutation in a large Czech pedigree with benign_neonatal_convulsions or other epileptic phenotypes .
15603955	0	potassium	89,98	KCNQ2	83,88	potassium	KCNQ2	MESH:D011188	3785	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	-LRB- S , E -RRB- - N - -LSB- 1 - -LRB- 3-heteroarylphenyl -RRB- ethyl -RSB- -3 - -LRB- 2-fluorophenyl -RRB- acrylamides : synthesis and KCNQ2 potassium channel opener activity .
16260777	0	potassium	53,62	KCNQ2	87,92	potassium	KCNQ2	MESH:D011188	3785	Chemical	Gene	impairment|compound|START_ENTITY impairment|nmod|C C|compound|END_ENTITY	Decreased_subunit_stability as a novel mechanism for potassium current impairment by a KCNQ2 C terminus mutation causing benign_familial_neonatal_convulsions .
16263935	0	potassium	41,50	KCNQ2	35,40	potassium	KCNQ2	MESH:D011188	170848(Tax:10116)	Chemical	Gene	fragment|compound|START_ENTITY fragment|compound|END_ENTITY	Expression of a calmodulin-binding KCNQ2 potassium channel fragment modulates neuronal M-current and membrane excitability .
16500630	0	potassium	38,47	KCNQ2	32,37	potassium	KCNQ2	MESH:D011188	16536(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|analysis analysis|nmod|END_ENTITY	Immunohistochemical analysis of KCNQ2 potassium channels in adult and developing mouse brain .
17475800	0	potassium	26,35	KCNQ2	110,115	potassium	KCNQ2	MESH:D011188	3785	Chemical	Gene	channels|compound|START_ENTITY gating|nmod|channels conferred|nsubj|gating conferred|nmod|region region|nmod|END_ENTITY	Atypical gating of M-type potassium channels conferred by mutations in uncharged residues in the S4 region of KCNQ2 causing benign_familial_neonatal_convulsions .
17993630	0	potassium	46,55	KCNQ2	40,45	potassium	KCNQ2	MESH:D011188	3785	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Calmodulin regulates the trafficking of KCNQ2 potassium channels .
23542819	0	potassium	82,91	KCNQ2	76,81	potassium	KCNQ2	MESH:D011188	3785	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	The ethylene_bis-dithiocarbamate fungicide Mancozeb activates voltage-gated KCNQ2 potassium channel .
23933653	0	potassium	57,66	KCNQ2	51,56	potassium	KCNQ2	MESH:D011188	3785	Chemical	Gene	channels|compound|START_ENTITY channels|nummod|END_ENTITY	Discovery of a retigabine derivative that inhibits KCNQ2 potassium channels .
23977150	0	potassium	47,56	KCNQ2	11,16	potassium	KCNQ2	MESH:D011188	16536(Tax:10090)	Chemical	Gene	currents|compound|START_ENTITY truncation|nmod|currents truncation|nsubj|Effects Effects|nmod|gene gene|compound|END_ENTITY	Effects of KCNQ2 gene truncation on M-type Kv7 potassium currents .
25077630	0	potassium	53,62	KCNQ2	116,121	potassium	KCNQ2	MESH:D011188	170848(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY expression|nmod|channels regulated|nsubjpass|expression regulated|nmod|subunit subunit|compound|END_ENTITY	Polarized axonal surface expression of neuronal KCNQ potassium channels is regulated by calmodulin interaction with KCNQ2 subunit .
9425895	0	potassium	8,17	KCNQ2	32,37	potassium	KCNQ2	MESH:D011188	3785	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A novel potassium channel gene , KCNQ2 , is mutated in an inherited_epilepsy_of_newborns .
9827540	0	potassium	10,19	KCNQ2	4,9	potassium	KCNQ2	MESH:D011188	3785	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	The KCNQ2 potassium channel : splice variants , functional and developmental expression .
16513263	0	potassium	38,47	KCNQ3	32,37	potassium	KCNQ3	MESH:D011188	110862(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Immunohistochemical analysis of KCNQ3 potassium channels in mouse brain .
18425618	0	potassium	14,23	KCNQ3	8,13	potassium	KCNQ3	MESH:D011188	3786	Chemical	Gene	function|compound|START_ENTITY function|compound|END_ENTITY	Altered KCNQ3 potassium channel function caused by the W309R pore-helix mutation found in human epilepsy .
19167866	0	potassium	8,17	KCNQ3	42,47	potassium	KCNQ3	MESH:D011188	3786	Chemical	Gene	Lack|nmod|START_ENTITY benign_familial_neonatal_convulsions|nsubj|Lack benign_familial_neonatal_convulsions|amod|current current|nmod|channel channel|compound|END_ENTITY	Lack of potassium current in W309R mutant KCNQ3 channel causing benign_familial_neonatal_convulsions -LRB- BFNC -RRB- .
20610766	0	potassium	28,37	KCNQ3	22,27	potassium	KCNQ3	MESH:D011188	3786	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	A pore residue of the KCNQ3 potassium M-channel subunit controls surface expression .
9836639	0	potassium	16,25	KCNQ3	10,15	potassium	KCNQ3	MESH:D011188	3786	Chemical	Gene	subunits|compound|START_ENTITY subunits|nummod|END_ENTITY	KCNQ2 and KCNQ3 potassium channel subunits : molecular correlates of the M-channel .
10025409	0	potassium	15,24	KCNQ4	0,5	potassium	KCNQ4	MESH:D011188	9132	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|appos|channel	KCNQ4 , a novel potassium channel expressed in sensory outer hair cells , is mutated in dominant deafness .
20876743	0	potassium	57,66	KCNQ4	88,93	potassium	KCNQ4	MESH:D011188	298496(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY distinguishes|nmod|channels composed|nsubj|distinguishes composed|nmod|subunits subunits|compound|END_ENTITY	Diclofenac distinguishes among homomeric and heteromeric potassium channels composed of KCNQ4 and KCNQ5 subunits .
22319145	0	potassium	18,27	KCNQ4	60,65	potassium	KCNQ4	MESH:D011188	9132	Chemical	Gene	channel|compound|START_ENTITY KQT|nsubj|channel KQT|ccomp|displays displays|nsubj|member member|appos|END_ENTITY	The voltage-gated potassium channel subfamily KQT member 4 -LRB- KCNQ4 -RRB- displays parallel evolution in echolocating bats .
10787416	0	potassium	56,65	KCNQ5	47,52	potassium	KCNQ5	MESH:D011188	56479	Chemical	Gene	subunit|compound|START_ENTITY Molecular|dobj|subunit Molecular|nmod|END_ENTITY	Molecular cloning and functional expression of KCNQ5 , a potassium channel subunit that may contribute to neuronal M-current diversity .
10816588	0	potassium	15,24	KCNQ5	0,5	potassium	KCNQ5	MESH:D011188	56479	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|appos|channel	KCNQ5 , a novel potassium channel broadly expressed in brain , mediates M-type currents .
15963599	0	potassium	10,19	KCNQ5	4,9	potassium	KCNQ5	MESH:D011188	226922(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	The KCNQ5 potassium channel from mouse : a broadly expressed M-current like potassium channel modulated by zinc , pH , and volume changes .
15963599	0	potassium	75,84	KCNQ5	4,9	potassium	KCNQ5	MESH:D011188	226922(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY M-current|nmod|channel channel|dep|M-current channel|compound|END_ENTITY	The KCNQ5 potassium channel from mouse : a broadly expressed M-current like potassium channel modulated by zinc , pH , and volume changes .
20534576	0	potassium	10,19	KCNQ5	4,9	potassium	KCNQ5	MESH:D011188	226922(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	The KCNQ5 potassium channel mediates a component of the afterhyperpolarization current in mouse hippocampus .
22937123	0	potassium	30,39	KCNS3	24,29	potassium	KCNS3	MESH:D011188	3790	Chemical	Gene	a-subunit|compound|START_ENTITY a-subunit|compound|END_ENTITY	Selective expression of KCNS3 potassium channel a-subunit in parvalbumin-containing GABA neurons in the human prefrontal cortex .
24170294	0	potassium	32,41	KCNS3	26,31	potassium	KCNS3	MESH:D011188	3790	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Lower gene expression for KCNS3 potassium channel subunit in parvalbumin-containing neurons in the prefrontal cortex in schizophrenia .
19032868	0	potassium	40,49	KCTD9	25,30	potassium	KCTD9	MESH:D011188	54793	Chemical	Gene	gene|compound|START_ENTITY expression|appos|gene expression|nmod|END_ENTITY	-LSB- Increased expression of KCTD9 , a novel potassium channel related gene , correlates with disease severity in patients with viral_hepatitis_B -RSB- .
22433305	0	potassium	16,25	KCTD9	1,6	potassium	KCTD9	MESH:D011188	105440(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|appos|channel	-LSB- KCTD9 , a novel potassium channel related gene , was highly expressed in hepatic NK cells and T cells of fulminant hepatitis mice induced by MHV-3 -RSB- .
11351020	0	potassium	21,30	KChIP2	14,20	potassium	KChIP2	MESH:D011188	30819	Chemical	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Regulation of KChIP2 potassium channel beta subunit gene expression underlies the gradient of transient outward current in canine and human ventricle .
15107477	0	potassium	73,82	KChIP2	6,12	potassium	KChIP2	MESH:D011188	30819	Chemical	Gene	currents|compound|START_ENTITY diversity|nmod|currents isoforms|dobj|diversity isoforms|nsubj|END_ENTITY	Novel KChIP2 isoforms increase functional diversity of transient outward potassium currents .
21252158	0	potassium	58,67	KChIP2	103,109	potassium	KChIP2	MESH:D011188	56817(Tax:10116)	Chemical	Gene	downregulates|iobj|START_ENTITY downregulates|nmod|control control|nmod|expression expression|amod|END_ENTITY	Nuclear factor kappaB downregulates the transient outward potassium current I -LRB- to , f -RRB- through control of KChIP2 expression .
22307618	0	potassium	70,79	KChIP2	63,69	potassium	KChIP2	MESH:D011188	30819	Chemical	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Evolution of CpG island promoter function underlies changes in KChIP2 potassium channel subunit gene expression in mammalian heart .
25228688	0	potassium	32,41	KChIP3	85,91	potassium	KChIP3	MESH:D011188	30818	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Modulation of the voltage gated potassium channel -LRB- Kv4 .3 -RRB- and the auxiliary protein -LRB- KChIP3 -RRB- interactions by the current activator NS5806 .
8528244	0	potassium	30,39	KVLQT1	54,60	potassium	KVLQT1	MESH:D011188	3784	Chemical	Gene	gene|compound|START_ENTITY cloning|nmod|gene cloning|dep|mutations mutations|nummod|END_ENTITY	Positional cloning of a novel potassium channel gene : KVLQT1 mutations cause cardiac_arrhythmias .
9570196	0	potassium	28,37	KVLQT1	21,27	potassium	KVLQT1	MESH:D011188	3784	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	New mutations in the KVLQT1 potassium channel that cause long-QT_syndrome .
18199775	0	potassium	49,58	KVS-1	43,48	potassium	KVS-1	MESH:D011188	183753(Tax:6239)	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Cumulative activation of voltage-dependent KVS-1 potassium channels .
12611901	0	potassium	29,38	KZM1	15,19	potassium	KZM1	MESH:D011188	542145(Tax:4577)	Chemical	Gene	uptake|compound|START_ENTITY mediates|dobj|uptake mediates|nsubj|END_ENTITY	The K + channel KZM1 mediates potassium uptake into the phloem and guard cells of the C4 grass Zea_mays .
8760241	0	potassium	55,64	Kcn1	36,40	potassium	Kcn1	MESH:D011188	100009396(Tax:9986)	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|appos|channel	Genomic structure and regulation of Kcn1 , a cGMP-gated potassium channel .
22927438	0	potassium	20,29	Kcnh1	0,5	potassium	Kcnh1	MESH:D011188	560568(Tax:7955)	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Kcnh1 voltage-gated potassium channels are essential for early zebrafish development .
11042260	0	potassium	58,67	Kcnj13	82,88	potassium	Kcnj13	MESH:D011188	94341(Tax:10116)	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genomic structure and promoter analysis of the rat kir7 .1 potassium channel gene -LRB- Kcnj13 -RRB- .
11886861	0	potassium	48,57	Kcnk3	22,27	potassium	Kcnk3	MESH:D011188	3777	Chemical	Gene	START_ENTITY|nsubj|Modulation Modulation|nmod|TASK-1 TASK-1|appos|END_ENTITY	Modulation of TASK-1 -LRB- Kcnk3 -RRB- and TASK-3 -LRB- Kcnk9 -RRB- potassium channels : volatile anesthetics and neurotransmitters share a molecular site of action .
11886861	0	potassium	48,57	Kcnk9	41,46	potassium	Kcnk9	MESH:D011188	51305	Chemical	Gene	START_ENTITY|nsubj|Modulation Modulation|nmod|TASK-1 TASK-1|appos|END_ENTITY	Modulation of TASK-1 -LRB- Kcnk3 -RRB- and TASK-3 -LRB- Kcnk9 -RRB- potassium channels : volatile anesthetics and neurotransmitters share a molecular site of action .
15347667	0	potassium	68,77	Kcnn4	86,91	potassium	Kcnn4	MESH:D011188	16534(Tax:10090)	Chemical	Gene	channel|nsubj|START_ENTITY channel|dobj|END_ENTITY	Physiological roles of the intermediate conductance , Ca2 + - activated potassium channel Kcnn4 .
20616305	0	potassium	8,17	Kcnn4	38,43	potassium	Kcnn4	MESH:D011188	65206(Tax:10116)	Chemical	Gene	efflux|compound|START_ENTITY efflux|acl|mediated mediated|nmod|channels channels|amod|END_ENTITY	Mucosal potassium efflux mediated via Kcnn4 channels provides the driving force for electrogenic anion secretion in colon .
16463373	0	potassium	48,57	Kcnq1	24,29	potassium	Kcnq1	MESH:D011188	16535(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|distribution distribution|nmod|END_ENTITY	Protein distribution of Kcnq1 , Kcnh2 , and Kcne3 potassium channel subunits during mouse embryonic development .
17660684	0	potassium	59,68	Kcnq1	53,58	potassium	Kcnq1	MESH:D011188	16535(Tax:10090)	Chemical	Gene	mutation|compound|START_ENTITY mutation|amod|END_ENTITY	Phenotypic analysis of vertigo 2 Jackson mice with a Kcnq1 potassium channel mutation .
16563220	0	potassium	20,29	Kir	40,43	potassium	Kir	MESH:D011188	3805	Chemical	Gene	channels|compound|START_ENTITY channels|appos|END_ENTITY	Inwardly rectifying potassium channels -LRB- Kir -RRB- in central nervous system glia : a special role for Kir4 .1 in glial functions .
17326663	0	potassium	60,69	Kir	55,58	potassium	Kir	MESH:D011188	3805	Chemical	Gene	channels|compound|START_ENTITY channels|amod|rectifying rectifying|dep|END_ENTITY	Molecular dynamics simulations of inwardly rectifying -LRB- Kir -RRB- potassium channels : a comparative study .
17698013	0	potassium	62,71	Kir	58,61	potassium	Kir	MESH:D011188	3805	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	H bonding at the helix-bundle crossing controls gating in Kir potassium channels .
24409153	0	potassium	48,57	Kir	59,62	potassium	Kir	MESH:D011188	3805	Chemical	Gene	START_ENTITY|dobj|channels channels|appos|END_ENTITY	Phosphoinositide regulation of inward rectifier potassium -LRB- Kir -RRB- channels .
14614103	0	potassium	30,39	Kv1	18,21	potassium	Kv1	MESH:D011188	25470(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|roles roles|nmod|END_ENTITY	Distinct roles of Kv1 and Kv3 potassium channels at the calyx of Held presynaptic terminal .
18026984	0	potassium	13,22	Kv1	0,3	potassium	Kv1	MESH:D011188	25470(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Kv1 and Kir2 potassium channels are expressed in rat brain endothelial cells .
18053989	0	potassium	35,44	Kv1	31,34	potassium	Kv1	MESH:D011188	25470(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Expression and localization of Kv1 potassium channels in rat dorsal and ventral spinal roots .
21339955	0	potassium	34,43	Kv1	30,33	potassium	Kv1	MESH:D011188	25470(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Screening and cDNA cloning of Kv1 potassium channel toxins in sea anemones .
21451062	0	potassium	58,67	Kv1	36,39	potassium	Kv1	MESH:D011188	25470(Tax:10116)	Chemical	Gene	currents|amod|START_ENTITY currents|amod|END_ENTITY	Postnatal development of A-type and Kv1 - and Kv2-mediated potassium channel currents in neocortical pyramidal neurons .
21647367	0	potassium	12,21	Kv1	8,11	potassium	Kv1	MESH:D011188	25470(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Role of Kv1 potassium channels in regulating dopamine release and presynaptic D2 receptor function .
24948003	0	potassium	49,58	Kv1	31,34	potassium	Kv1	MESH:D011188	25470(Tax:10116)	Chemical	Gene	family|compound|START_ENTITY family|amod|END_ENTITY	Differential expression of the Kv1 voltage-gated potassium channel family in the rat nephron .
9305996	0	potassium	49,58	Kv1	87,90	potassium	Kv1	MESH:D011188	25470(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY basis|nmod|channels basis|nmod|family family|amod|END_ENTITY	Molecular basis for different pore properties of potassium channels from the rat brain Kv1 gene family .
9738007	1	potassium	166,175	Kv1	162,165	potassium	Kv1	MESH:D011188	25470(Tax:10116)	Chemical	Gene	toxins|compound|START_ENTITY toxins|amod|END_ENTITY	The functional topographies of dendrotoxins are different but share a conserved core with those of other Kv1 potassium channel-blocking toxins .
15207333	0	potassium	15,24	Kv3	33,36	potassium	Kv3	MESH:D011188	29731(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY Association|nmod|channel END_ENTITY|nsubj|Association	Association of potassium channel Kv3 .4 subunits with pre - and post-synaptic structures in brainstem and spinal cord .
19634181	0	potassium	42,51	Kv3	38,41	potassium	Kv3	MESH:D011188	29731(Tax:10116)	Chemical	Gene	subunits|compound|START_ENTITY subunits|amod|END_ENTITY	Quantitative analysis of neurons with Kv3 potassium channel subunits , Kv3 .1 b and Kv3 .2 , in macaque primary visual cortex .
8081714	0	potassium	52,61	Kv3	48,51	potassium	Kv3	MESH:D011188	29731(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Mechanism and modulation of inactivation of the Kv3 potassium channel .
10051143	0	potassium	45,54	Kv4	31,34	potassium	Kv4	MESH:D011188	16502(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY family|nmod|channels family|amod|END_ENTITY	Effects of phrixotoxins on the Kv4 family of potassium channels and implications for the role of Ito1 in cardiac electrogenesis .
10228180	0	potassium	27,36	Kv4	23,26	potassium	Kv4	MESH:D011188	3746	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Inactivation gating of Kv4 potassium channels : molecular interactions involving the inner vestibule of the pore .
11805342	0	potassium	47,56	Kv4	36,39	potassium	Kv4	MESH:D011188	3746	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Elimination of fast inactivation in Kv4 A-type potassium channels by an auxiliary subunit domain .
12381814	0	potassium	47,56	Kv4	16,19	potassium	Kv4	MESH:D011188	16502(Tax:10090)	Chemical	Gene	current|compound|START_ENTITY Contribution|nmod|current Contribution|nmod|channels channels|amod|END_ENTITY	Contribution of Kv4 channels toward the A-type potassium current in murine colonic myocytes .
15096626	0	potassium	73,82	Kv4	69,72	potassium	Kv4	MESH:D011188	3746	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Solution structure of Phrixotoxin 1 , a specific peptide inhibitor of Kv4 potassium channels from the venom of the theraphosid spider Phrixotrichus auratus .
19213956	0	potassium	4,13	Kv4	0,3	potassium	Kv4	MESH:D011188	3746	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Kv4 potassium channels form a tripartite complex with the anchoring protein SAP97 and CaMKII in cardiac myocytes .
19576909	0	potassium	123,132	Kv4	119,122	potassium	Kv4	MESH:D011188	25469(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	SP protects cerebellar granule cells against beta-amyloid-induced apoptosis by down-regulation and reduced activity of Kv4 potassium channels .
20849929	0	potassium	35,44	Kv4	31,34	potassium	Kv4	MESH:D011188	25469(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Expression and distribution of Kv4 potassium channel subunits and potassium channel interacting proteins in subpopulations of interneurons in the basolateral amygdala .
22700470	0	potassium	4,13	Kv4	0,3	potassium	Kv4	MESH:D011188	25469(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Kv4 potassium channels modulate hippocampal EPSP-spike potentiation and spatial memory in rats .
10409658	0	potassium	68,77	KvLQT1	61,67	potassium	KvLQT1	MESH:D011188	447049(Tax:8355)	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Long_QT_syndrome-associated mutations in the S4-S5 linker of KvLQT1 potassium channels modify gating and interaction with minK subunits .
10483966	0	potassium	129,138	KvLQT1	113,119	potassium	KvLQT1	MESH:D011188	3784	Chemical	Gene	defects|compound|START_ENTITY defects|compound|END_ENTITY	Sinus node function and ventricular repolarization during exercise stress test in long_QT_syndrome patients with KvLQT1 and HERG potassium channel defects .
11306689	0	potassium	42,51	KvLQT1	29,35	potassium	KvLQT1	MESH:D011188	3784	Chemical	Gene	channels|compound|START_ENTITY minK|appos|channels minK|amod|END_ENTITY	Cocaine blocks HERG , but not KvLQT1 + minK , potassium channels .
11414731	0	potassium	30,39	KvLQT1	23,29	potassium	KvLQT1	MESH:D011188	16535(Tax:10090)	Chemical	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Mice disrupted for the KvLQT1 potassium channel regulator IsK gene accumulate mature T cells .
12879210	0	potassium	52,61	KvLQT1	134,140	potassium	KvLQT1	MESH:D011188	373746(Tax:8355)	Chemical	Gene	channels|compound|START_ENTITY KvLQT1/MinK|dobj|channels KvLQT1/MinK|nmod|oocytes oocytes|nmod|phosphorylation phosphorylation|nmod|protein protein|amod|END_ENTITY	Human beta -LRB- 3 -RRB- - adrenoreceptors couple to KvLQT1/MinK potassium channels in Xenopus oocytes via protein_kinase_C phosphorylation of the KvLQT1 protein .
18037918	0	potassium	35,44	KvLQT1	28,34	potassium	KvLQT1	MESH:D011188	100379230(Tax:10141)	Chemical	Gene	current|compound|START_ENTITY current|amod|END_ENTITY	Chlorthalidone inhibits the KvLQT1 potassium current in guinea-pig ventricular myocytes and oocytes from Xenopus_laevis .
9108097	0	potassium	24,33	KvLQT1	0,6	potassium	KvLQT1	MESH:D011188	3784	Chemical	Gene	channel|nsubj|START_ENTITY channel|advmod|END_ENTITY	KvLQT1 , a voltage-gated potassium channel responsible for human cardiac_arrhythmias .
9396783	0	potassium	7,16	KvLQT1	0,6	potassium	KvLQT1	MESH:D011188	3784	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|dobj|channel	KvLQT1 potassium channel but not IsK is the molecular target for trans-6-cyano-4 - -LRB- N-ethylsulfonyl-N-methylamino -RRB- -3 - hydroxy-2 ,2 - dimethyl - _ chromane .
9675180	0	potassium	48,57	KvLQT1	41,47	potassium	KvLQT1	MESH:D011188	373746(Tax:8355)	Chemical	Gene	START_ENTITY|nsubj|Activation Activation|nmod|END_ENTITY	Activation and inactivation of homomeric KvLQT1 potassium channels .
9817805	0	potassium	53,62	KvLQT1	46,52	potassium	KvLQT1	MESH:D011188	447049(Tax:8355)	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Increase of the single-channel conductance of KvLQT1 potassium channels induced by the association with minK .
8549760	0	potassium	67,76	Kv_beta_3	57,66	potassium	Kv beta 3	MESH:D011188	58981(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|characterization characterization|nmod|END_ENTITY	Molecular and functional characterization of a rat brain Kv_beta_3 potassium channel subunit .
12604245	0	potassium	88,97	Kvbeta2	108,115	potassium	Kvbeta2	MESH:D011188	8514	Chemical	Gene	channels|compound|START_ENTITY channels|appos|END_ENTITY	Protein_kinase_C-dependent phosphorylation of the beta-subunit of the voltage-sensitive potassium channels -LRB- Kvbeta2 -RRB- .
18684900	0	potassium	4,13	Kvbeta2	48,55	potassium	Kvbeta2	MESH:D011188	399149(Tax:8355)	Chemical	Gene	complexes|compound|START_ENTITY require|nsubj|complexes require|dobj|subunits subunits|amod|END_ENTITY	Kv1 potassium channel complexes in vivo require Kvbeta2 subunits in dorsal spinal neurons .
10219239	0	potassium	16,25	MiRP1	0,5	potassium	MiRP1	MESH:D011188	9992	Chemical	Gene	channels|compound|START_ENTITY forms|dobj|channels forms|nsubj|END_ENTITY	MiRP1 forms IKr potassium channels with HERG and is associated with cardiac_arrhythmia .
11207363	0	potassium	12,21	MiRP2	0,5	potassium	MiRP2	MESH:D011188	10008	Chemical	Gene	channels|compound|START_ENTITY forms|dobj|channels forms|nsubj|END_ENTITY	MiRP2 forms potassium channels in skeletal muscle with Kv3 .4 and is associated with periodic paralysis .
10968999	0	potassium	22,31	MinK	0,4	potassium	MinK	MESH:D011188	50488	Chemical	Gene	pore|compound|START_ENTITY endows|dobj|pore endows|nsubj|END_ENTITY	MinK endows the I -LRB- Ks -RRB- potassium channel pore with sensitivity to internal tetraethylammonium .
10995738	0	potassium	31,40	MinK	25,29	potassium	MinK	MESH:D011188	16509(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Contribution Contribution|nmod|IsK IsK|appos|END_ENTITY	Contribution of the IsK -LRB- MinK -RRB- potassium channel subunit to regulatory volume decrease in murine tracheal epithelial cells .
1407274	0	potassium	37,46	MinK	32,36	potassium	MinK	MESH:D011188	398417(Tax:8355)	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Structure and regulation of the MinK potassium channel .
14679187	0	potassium	49,58	MinK	0,4	potassium	MinK	MESH:D011188	3753	Chemical	Gene	gating|amod|START_ENTITY diversify|dobj|gating diversify|nsubj|END_ENTITY	MinK , MiRP1 , and MiRP2 diversify Kv3 .1 and Kv3 .2 potassium channel gating .
19219384	0	potassium	24,33	MinK	45,49	potassium	MinK	MESH:D011188	3753	Chemical	Gene	channel|compound|START_ENTITY Regulation|nmod|channel Regulation|nmod|END_ENTITY	Regulation of the Kv2 .1 potassium channel by MinK and MiRP1 .
8785054	0	potassium	21,30	MinK	0,4	potassium	MinK	MESH:D011188	50488	Chemical	Gene	pore|compound|START_ENTITY line|dobj|pore line|nsubj|residues residues|compound|END_ENTITY	MinK residues line a potassium channel pore .
8999841	0	potassium	5,14	MinK	0,4	potassium	MinK	MESH:D011188	398417(Tax:8355)	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	MinK potassium channels are heteromultimeric complexes .
10436003	0	potassium	29,38	Mslo	51,55	potassium	Mslo	MESH:D011188	16531(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY currents|nmod|channels currents|compound|END_ENTITY	Allosteric voltage gating of potassium channels I. Mslo ionic currents in the absence of Ca -LRB- 2 + -RRB- .
8449507	0	potassium	41,50	NGK2-KV4	65,73	potassium	NGK2-KV4	MESH:D011188	3746	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Localization of a highly conserved human potassium channel gene -LRB- NGK2-KV4 ; KCNC1 -RRB- to chromosome 11p15 .
11692276	0	potassium	31,40	NKCC1	64,69	potassium	NKCC1	MESH:D011188	20496(Tax:10090)	Chemical	Gene	cotransport|dep|START_ENTITY Expression|nmod|cotransport Expression|appos|END_ENTITY	Expression and role of sodium , potassium , chloride cotransport -LRB- NKCC1 -RRB- in mouse inner medullary collecting duct -LRB- mIMCD-K2 -RRB- epithelial cells .
19374842	0	potassium	139,148	NOP	117,120	potassium	NOP	MESH:D011188	4987	Chemical	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	1-Benzyl-N - -LSB- 3 - -LSB- spiroisobenzofuran-1 -LRB- 3H -RRB- ,4 ' - piperidin-1-yl -RSB- propyl -RSB- pyrrolidine-2-carboxamide -LRB- Compound 24 -RRB- antagonizes NOP receptor-mediated potassium channel activation in rat periaqueductal gray slices .
4263055	0	potassium	30,39	Na-K-ATPase	64,75	potassium	Na-K-ATPase	MESH:D011188	396530(Tax:9031)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effects of incubations in low potassium and low sodium media on Na-K-ATPase activity in snake and chicken kidney slices .
16890525	0	potassium	64,73	ORK1	29,33	potassium	ORK1	MESH:D011188	32020(Tax:7227)	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|appos|channel	Control of cardiac rhythm by ORK1 , a Drosophila two-pore domain potassium channel .
15066141	0	potassium	33,42	PACAP	0,5	potassium	PACAP	MESH:D011188	24166(Tax:10116)	Chemical	Gene	current|compound|START_ENTITY inhibits|dobj|current inhibits|nsubj|END_ENTITY	PACAP inhibits delayed rectifier potassium current via a cAMP/PKA transduction pathway : evidence for the involvement of I k_in the anti-apoptotic action of PACAP .
15250762	0	potassium	27,36	PSD-95	15,21	potassium	PSD-95	MESH:D011188	1742	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|nmod|channels	Interaction of PSD-95 with potassium channels visualized by fluorescence lifetime-based resonance energy transfer imaging .
6487306	0	potassium	45,54	PTH	0,3	potassium	PTH	MESH:D011188	280903(Tax:9913)	Chemical	Gene	stimulated|nmod|START_ENTITY release|acl|stimulated release|compound|END_ENTITY	PTH release stimulated by high extracellular potassium is associated with a decrease in cytosolic calcium in bovine parathyroid cells .
10713964	0	potassium	67,76	Protein_kinase_C	0,16	potassium	Protein kinase C	MESH:D011188	100302324(Tax:10141)	Chemical	Gene	current|compound|START_ENTITY enhances|dobj|current enhances|nsubj|END_ENTITY	Protein_kinase_C enhances the rapidly activating delayed rectifier potassium current , IKr , through a reduction in C-type inactivation in guinea-pig ventricular myocytes .
8404907	1	potassium	156,165	RCK1	151,155	potassium	RCK1	MESH:D011188	24520(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	The monoclonal antibody K1C3 is specific for the RCK1 potassium channel .
10352359	0	potassium	23,32	ROMK	18,22	potassium	ROMK	MESH:D011188	447262(Tax:8355)	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Regulation of the ROMK potassium channel in the kidney .
12122007	0	potassium	56,65	ROMK	51,55	potassium	ROMK	MESH:D011188	56379(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Impaired_renal_NaCl_absorption in mice lacking the ROMK potassium channel , a model for type_II_Bartter 's _ syndrome .
12217853	0	potassium	33,42	ROMK	28,32	potassium	ROMK	MESH:D011188	447262(Tax:8355)	Chemical	Gene	START_ENTITY|nsubj|Evidence Evidence|nmod|endocytosis endocytosis|nmod|END_ENTITY	Evidence for endocytosis of ROMK potassium channel via clathrin-coated vesicles .
12952855	0	potassium	8,17	ROMK	56,60	potassium	ROMK	MESH:D011188	447262(Tax:8355)	Chemical	Gene	restriction|compound|START_ENTITY stimulates|nsubj|restriction stimulates|dobj|endocytosis endocytosis|nmod|channel channel|compound|END_ENTITY	Dietary potassium restriction stimulates endocytosis of ROMK channel in rat cortical collecting duct .
15454395	0	potassium	19,28	ROMK	14,18	potassium	ROMK	MESH:D011188	447262(Tax:8355)	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of ROMK potassium channel by syntaxin 1A .
15895241	0	potassium	18,27	ROMK	36,40	potassium	ROMK	MESH:D011188	3758	Chemical	Gene	channel|compound|START_ENTITY Expression|nmod|channel END_ENTITY|nsubj|Expression	Expression of the potassium channel ROMK in adult and fetal human kidney .
16775035	0	potassium	44,53	ROMK	39,43	potassium	ROMK	MESH:D011188	3758	Chemical	Gene	independent|compound|START_ENTITY independent|compound|END_ENTITY	WNK1 affects surface expression of the ROMK potassium channel independent of WNK4 .
19458126	0	potassium	34,43	ROMK	29,33	potassium	ROMK	MESH:D011188	3758	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	A comprehensive guide to the ROMK potassium channel : form and function in health and disease .
19841541	0	potassium	58,67	ROMK	53,57	potassium	ROMK	MESH:D011188	56379(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	The ARH adaptor protein regulates endocytosis of the ROMK potassium secretory channel in mouse kidney .
21262879	0	potassium	69,78	ROMK	63,67	potassium	ROMK	MESH:D011188	3758	Chemical	Gene	START_ENTITY|nsubj|expression expression|nmod|.1 .1|appos|END_ENTITY	Functional and developmental expression of a zebrafish Kir1 .1 -LRB- ROMK -RRB- potassium channel homologue Kcnj1 .
21433378	0	potassium	201,210	ROMK	43,47	potassium	ROMK	MESH:D011188	3758	Chemical	Gene	channel|compound|START_ENTITY Channel|appos|channel inhibitors|nmod|Channel identify|dobj|inhibitors is|xcomp|identify is|nsubj|Discovery Discovery|nmod|inhibitor inhibitor|nmod|END_ENTITY	Discovery of a small molecule inhibitor of ROMK and Kir7 .1 The specific aim of this project is to identify small molecule inhibitors of Renal Outer Medullary Potassium Channel -LRB- ROMK , Kir1 .1 , KCNJ1 -RRB- , a potassium channel located in the renal tubule , where it critically regulates sodium and potassium balance .
21433391	0	potassium	221,230	ROMK	43,47	potassium	ROMK	MESH:D011188	3758	Chemical	Gene	channel|compound|START_ENTITY Channel|appos|channel inhibitors|nmod|Channel identify|dobj|inhibitors is|xcomp|identify is|nsubj|Discovery Discovery|nmod|inhibitor inhibitor|nmod|END_ENTITY	Discovery of a small molecule inhibitor of ROMK with unprecedented selectivity The specific aim of this project is to identify small molecule inhibitors of Renal Outer Medullary Potassium Channel -LRB- ROMK , Kir1 .1 , KCNJ1 -RRB- , a potassium channel located in the renal tubule , where it critically regulates sodium and potassium balance .
21454252	0	potassium	79,88	ROMK	27,31	potassium	ROMK	MESH:D011188	56379(Tax:10090)	Chemical	Gene	segments|nmod|START_ENTITY regulation|nmod|segments regulation|nmod|END_ENTITY	Differential regulation of ROMK -LRB- Kir1 .1 -RRB- in distal nephron segments by dietary potassium .
24721647	0	potassium	31,40	ROMK	49,53	potassium	ROMK	MESH:D011188	3758	Chemical	Gene	channel|compound|START_ENTITY Targeting|dobj|channel END_ENTITY|csubj|Targeting	Targeting the inward-rectifier potassium channel ROMK in cardiovascular_disease .
8569061	0	potassium	38,47	ROMK	73,77	potassium	ROMK	MESH:D011188	3758	Chemical	Gene	channel|compound|START_ENTITY channel|nmod|kidney kidney|appos|END_ENTITY	An ATP-regulated , inwardly rectifying potassium channel from rat kidney -LRB- ROMK -RRB- .
8861938	0	potassium	84,93	ROMK	104,108	potassium	ROMK	MESH:D011188	3758	Chemical	Gene	channels|compound|START_ENTITY channels|appos|END_ENTITY	Identification of a titratable lysine residue that determines sensitivity of kidney potassium channels -LRB- ROMK -RRB- to intracellular pH. Potassium -LRB- K + -RRB- homeostasis is controlled by the secretion of K + ions across the apical membrane of renal collecting duct cells through a low-conductance inwardly rectifying K + channel .
9002665	0	potassium	61,70	ROMK	80,84	potassium	ROMK	MESH:D011188	3758	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Mutations in the gene encoding the inwardly-rectifying renal potassium channel , ROMK , cause the antenatal variant of Bartter_syndrome : evidence for genetic heterogeneity .
9729502	0	potassium	52,61	ROMK	47,51	potassium	ROMK	MESH:D011188	3758	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dobj|channels	Roles of Na-K-2Cl and Na-Cl cotransporters and ROMK potassium channels in urinary concentrating mechanism .
10744702	0	potassium	78,87	ROMK1	72,77	potassium	ROMK1	MESH:D011188	3758	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Phosphatidylinositol_4 ,5 - bisphosphate and intracellular pH regulate the ROMK1 potassium channel via separate but interrelated mechanisms .
11795013	0	potassium	135,144	ROMK1	129,134	potassium	ROMK1	MESH:D011188	3758	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Neonatal Bartter disease diagnosed with the detection of a mutation of the KCNJ1 gene which codifies the synthesis of the renal ROMK1 potassium channel -RSB- .
8057249	0	potassium	47,56	ROMK1	41,46	potassium	ROMK1	MESH:D011188	447262(Tax:8355)	Chemical	Gene	channels|compound|START_ENTITY channels|nummod|END_ENTITY	Mg -LRB- 2 + -RRB- - dependent inward rectification of ROMK1 potassium channels expressed in Xenopus oocytes .
9136668	0	potassium	56,65	ROMK1	34,39	potassium	ROMK1	MESH:D011188	24521(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY permeation|appos|channel permeation|nmod|END_ENTITY	Cation permeation and blockade of ROMK1 , a cloned renal potassium channel .
9391167	0	potassium	32,41	ROMK1	51,56	potassium	ROMK1	MESH:D011188	3758	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Structural activity of a cloned potassium channel -LRB- ROMK1 -RRB- monitored with the atomic force microscope : the `` molecular-sandwich '' technique .
9401967	0	potassium	41,50	SHA	63,66	potassium	SHA	MESH:D011188	109556(Tax:10090)	Chemical	Gene	current|compound|START_ENTITY current|appos|END_ENTITY	A novel slow hyperpolarization-activated potassium current -LRB- IK -LRB- SHA -RRB- -RRB- from a mouse hippocampal cell line .
10516439	0	potassium	87,96	SK1	105,108	potassium	SK1	MESH:D011188	3780	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Gene structure and chromosome mapping of the human small-conductance calcium-activated potassium channel SK1 gene -LRB- KCNN1 -RRB- .
11146124	0	potassium	76,85	SK1	96,99	potassium	SK1	MESH:D011188	3780	Chemical	Gene	channels|compound|START_ENTITY channels|appos|END_ENTITY	Quantitative expression analysis of the small conductance calcium-activated potassium channels , SK1 , SK2 and SK3 , in human brain .
11844726	0	potassium	18,27	SK1	36,39	potassium	SK1	MESH:D011188	3780	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Calcium-activated potassium channel SK1 - and IK1-like immunoreactivity in injured human sensory neurones and its regulation by neurotrophic factors .
12850554	0	potassium	83,92	SK1	102,105	potassium	SK1	MESH:D011188	3780	Chemical	Gene	channels|compound|START_ENTITY calcium-activated|iobj|channels calcium-activated|dobj|END_ENTITY	The antidepressant fluoxetine blocks the human small conductance calcium-activated potassium channels SK1 , SK2 and SK3 .
14761961	0	potassium	41,50	SK1	59,62	potassium	SK1	MESH:D011188	54261(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY analysis|nmod|channel END_ENTITY|nsubj|analysis	Domain analysis of the calcium-activated potassium channel SK1 from rat brain .
15234350	0	potassium	87,96	SK1	115,118	potassium	SK1	MESH:D011188	103985(Tax:10090)	Chemical	Gene	channel|nsubj|START_ENTITY channel|dobj|END_ENTITY	Comparative immunohistochemical distribution of three small-conductance Ca2 + - activated potassium channel subunits , SK1 , SK2 , and SK3 in mouse brain .
10702465	0	potassium	104,113	SK2	65,68	potassium	SK2	MESH:D011188	3781	Chemical	Gene	channels|compound|START_ENTITY subtype|dobj|channels subtype|nsubj|analysis analysis|nmod|interactions interactions|nmod|END_ENTITY	Patch-clamp analysis of anesthetic interactions with recombinant SK2 subtype neuronal calcium-activated potassium channels .
12850554	0	potassium	83,92	SK2	107,110	potassium	SK2	MESH:D011188	3781	Chemical	Gene	channels|compound|START_ENTITY calcium-activated|iobj|channels calcium-activated|dobj|SK1 SK1|nummod|END_ENTITY	The antidepressant fluoxetine blocks the human small conductance calcium-activated potassium channels SK1 , SK2 and SK3 .
15234350	0	potassium	87,96	SK2	120,123	potassium	SK2	MESH:D011188	109666(Tax:10090)	Chemical	Gene	channel|nsubj|START_ENTITY channel|dobj|SK1 SK1|nummod|END_ENTITY	Comparative immunohistochemical distribution of three small-conductance Ca2 + - activated potassium channel subunits , SK1 , SK2 , and SK3 in mouse brain .
17396235	0	potassium	57,66	SK2	75,78	potassium	SK2	MESH:D011188	54262(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY channel|nsubj|regulation channel|dobj|promoters promoters|nummod|END_ENTITY	Transcriptional regulation of intronic calcium-activated potassium channel SK2 promoters by nuclear factor-kappa B and glucocorticoids .
18818242	0	potassium	40,49	SK2	18,21	potassium	SK2	MESH:D011188	109666(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Expression of the SK2 calcium-activated potassium channel is required for cholinergic function in mouse cochlear hair cells .
19204724	0	potassium	4,13	SK2	0,3	potassium	SK2	MESH:D011188	56848	Chemical	Gene	overexpression|compound|START_ENTITY overexpression|compound|END_ENTITY	SK2 potassium channel overexpression in basolateral amygdala reduces anxiety , stress-induced corticosterone secretion and dendritic arborization .
21426750	0	potassium	47,56	SK2	66,69	potassium	SK2	MESH:D011188	3781	Chemical	Gene	current|compound|START_ENTITY current|appos|channel channel|compound|END_ENTITY	-LSB- Increased small conductance calcium-activated potassium channel -LRB- SK2 channel -RRB- current in atrial myocytes of patients with persistent atrial_fibrillation -RSB- .
12813145	0	potassium	111,120	SK3	122,125	potassium	SK3	MESH:D011188	140493(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Urinary_bladder_instability induced by selective suppression of the murine small conductance calcium-activated potassium -LRB- SK3 -RRB- channel .
12875918	0	potassium	69,78	SK3	88,91	potassium	SK3	MESH:D011188	3782	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Expression and distribution of a small-conductance calcium-activated potassium channel -LRB- SK3 -RRB- protein in skeletal muscles from myotonic_muscular_dystrophy patients and congenital_myotonic_mice .
18703580	0	potassium	50,59	SK3	70,73	potassium	SK3	MESH:D011188	54263(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|appos|END_ENTITY	Expression of small-conductance calcium-activated potassium channels -LRB- SK3 -RRB- in skeletal muscle : regulation by muscle activity .
19472917	0	potassium	94,103	SK3	113,116	potassium	SK3	MESH:D011188	3782	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Analysis of Single Nucleotide Polymorphisms -LRB- SNPs -RRB- of the small-conductance calcium activated potassium channel -LRB- SK3 -RRB- gene as genetic modifier of the cardiac phenotype in myotonic_dystrophy type 1 patients .
24505302	0	potassium	54,63	SK3	83,86	potassium	SK3	MESH:D011188	54263(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY subtype|nsubj|channel subtype|dobj|3 3|appos|END_ENTITY	Expression of the small conductance Ca - activated potassium channel subtype 3 -LRB- SK3 -RRB- in rat uterus after stimulation with 17b-estradiol .
25783396	0	potassium	60,69	SK3	78,81	potassium	SK3	MESH:D011188	3782	Chemical	Gene	distribution|nmod|START_ENTITY channel|nsubj|distribution channel|dobj|END_ENTITY	Altered distribution of small-conductance calcium-activated potassium channel SK3 in Hirschsprung 's _ disease .
26619845	0	potassium	40,49	SK3	61,64	potassium	SK3	MESH:D011188	3782	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	The small conductance calcium-activated potassium channel 3 -LRB- SK3 -RRB- is a molecular target for Edelfosine to reduce the invasive potential of urothelial_carcinoma cells .
26711779	0	potassium	52,61	SK3	73,76	potassium	SK3	MESH:D011188	3782	Chemical	Gene	channel|compound|START_ENTITY Erratum|dep|channel Erratum|appos|END_ENTITY	Erratum to : The small conductance calcium-activated potassium channel 3 -LRB- SK3 -RRB- is a molecular target for Edelfosine to reduce the invasive potential of urothelial_carcinoma cells .
22041182	0	potassium	113,122	SK4	132,135	potassium	SK4	MESH:D011188	16534(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Control of hypothalamic-pituitary-adrenal stress axis activity by the intermediate conductance calcium-activated potassium channel , SK4 .
26725737	0	potassium	79,88	SK4	57,60	potassium	SK4	MESH:D011188	3783	Chemical	Gene	channels|compound|START_ENTITY channels|nummod|END_ENTITY	Mechanisms underlying the cardiac pacemaker : the role of SK4 calcium-activated potassium channels .
26100633	0	potassium	187,196	SLICK	69,74	potassium	SLICK	MESH:D011188	304827(Tax:10116)	Chemical	Gene	SLACK|compound|START_ENTITY contribute|nsubj|SLACK shown|ccomp|contribute remains|advcl|shown UNASSIGNED|parataxis|remains UNASSIGNED|nsubj|Regulation Regulation|nmod|promoter promoter|compound|END_ENTITY	Transcriptional Regulation of the Sodium-activated Potassium Channel SLICK -LRB- KCNT2 -RRB- promoter by nuclear factor-kappa B. UNASSIGNED : Although recent studies have shown the sodium-activated potassium channel SLACK -LRB- KCNT1 -RRB- can contribute to neuronal excitability , there remains little information on the physiological role of the closely related SLICK -LRB- KCNT2 -RRB- channel .
11738032	0	potassium	6,15	SLO-1	0,5	potassium	SLO-1	MESH:D011188	180203(Tax:6239)	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	SLO-1 potassium channels control quantal content of neurotransmitter release at the C. _ elegans neuromuscular junction .
17583712	0	potassium	22,31	SLO-1	41,46	potassium	SLO-1	MESH:D011188	180203(Tax:6239)	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	The calcium-activated potassium channel , SLO-1 , is required for the action of the novel cyclo-octadepsipeptide anthelmintic , emodepside , in Caenorhabditis_elegans .
25300429	0	potassium	6,15	SLO-2	0,5	potassium	SLO-2	MESH:D011188	181332(Tax:6239)	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	SLO-2 potassium channel is an important regulator of neurotransmitter release in Caenorhabditis_elegans .
15998639	0	potassium	28,37	SLO1	22,26	potassium	SLO1	MESH:D011188	3778	Chemical	Gene	START_ENTITY|nsubj|Activation Activation|appos|END_ENTITY	Activation of the BK -LRB- SLO1 -RRB- potassium channel by mallotoxin .
20138882	0	potassium	24,33	SLO3	4,8	potassium	SLO3	MESH:D011188	157855	Chemical	Gene	channel|compound|START_ENTITY channel|nummod|END_ENTITY	The SLO3 sperm-specific potassium channel plays a vital role in male fertility .
21946432	0	potassium	74,83	SSAT	58,62	potassium	SSAT	MESH:D011188	20229(Tax:10090)	Chemical	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Integrin a9b1-mediated cell migration in glioblastoma via SSAT and Kir4 .2 potassium channel pathway .
24586202	0	potassium	151,160	SUP-9	169,174	potassium	SUP-9	MESH:D011188	173613(Tax:6239)	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|nsubj|channel	The Caenorhabditis_elegans iodotyrosine deiodinase ortholog SUP-18 functions through a conserved channel SC-box to regulate the muscle two-pore domain potassium channel SUP-9 .
15296637	0	potassium	141,150	SUR1	168,172	potassium	SUR1	MESH:D011188	6833	Chemical	Gene	channels|compound|START_ENTITY channels|appos|END_ENTITY	Establishment and application of in vitro membrane potential assays in cell lines with endogenous or recombinant expression of ATP-sensitive potassium channels -LRB- Kir6 .2 / SUR1 -RRB- using a fluorescent probe kit .
16475928	0	potassium	30,39	SUR1	25,29	potassium	SUR1	MESH:D011188	6833	Chemical	Gene	openers|compound|START_ENTITY openers|nummod|END_ENTITY	Towards selective Kir6 .2 / SUR1 potassium channel openers , medicinal chemistry and therapeutic perspectives .
23678128	2	potassium	343,352	SUR1	448,452	potassium	SUR1	MESH:D011188	20927(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY loop|nmod|channel directly|nmod|loop receptor|amod|directly consisting|nsubj|receptor consisting|nmod|amino_acids amino_acids|dep|859-881 859-881|dep|END_ENTITY	Here we show that EPAC binds directly to the intracellular loop of an ATP-sensitive potassium -LRB- KATP -RRB- channel type-1 sulfonylurea receptor -LRB- SUR1 -RRB- receptor consisting of amino_acids 859-881 -LRB- SUR1 -LRB- 859-881 -RRB- -RRB- .
2122520	0	potassium	49,58	ShB	94,97	potassium	ShB	MESH:D011188	252628	Chemical	Gene	channels|compound|START_ENTITY Restoration|nmod|channels Restoration|acl|derived derived|nmod|END_ENTITY	Restoration of inactivation in mutants of Shaker potassium channels by a peptide derived from ShB .
2484347	0	potassium	25,34	ShB	14,17	potassium	ShB	MESH:D011188	252628	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Properties of ShB A-type potassium channels expressed in Shaker mutant Drosophila by germline transformation .
1697898	0	potassium	87,96	Shaker	123,129	potassium	Shaker	MESH:D011188	32780(Tax:7227)	Chemical	Gene	channels|compound|START_ENTITY role|nmod|channels role|acl|derived derived|nmod|gene gene|compound|END_ENTITY	The role of the divergent amino and carboxyl domains on the inactivation properties of potassium channels derived from the Shaker gene of Drosophila .
2001287	0	potassium	6,15	Shaker	40,46	potassium	Shaker	MESH:D011188	32780(Tax:7227)	Chemical	Gene	channels|compound|START_ENTITY encoded|nsubj|channels encoded|nmod|locus locus|compound|END_ENTITY	Novel potassium channels encoded by the Shaker locus in Drosophila photoreceptors .
2122519	0	potassium	47,56	Shaker	40,46	potassium	Shaker	MESH:D011188	32780(Tax:7227)	Chemical	Gene	START_ENTITY|nsubj|mechanisms mechanisms|nmod|END_ENTITY	Biophysical and molecular mechanisms of Shaker potassium channel inactivation .
2440582	0	potassium	71,80	Shaker	30,36	potassium	Shaker	MESH:D011188	32780(Tax:7227)	Chemical	Gene	channel|compound|START_ENTITY encodes|dobj|channel gene|acl:relcl|encodes characterization|appos|gene characterization|nmod|END_ENTITY	Molecular characterization of Shaker , a Drosophila gene that encodes a potassium channel .
2448636	0	potassium	25,34	Shaker	49,55	potassium	Shaker	MESH:D011188	32780(Tax:7227)	Chemical	Gene	channels|compound|START_ENTITY channels|nmod|cDNA cDNA|compound|END_ENTITY	Expression of functional potassium channels from Shaker cDNA in Xenopus oocytes .
2456579	0	potassium	7,16	Shaker	41,47	potassium	Shaker	MESH:D011188	32780(Tax:7227)	Chemical	Gene	channels|compound|START_ENTITY expressed|nsubj|channels expressed|nmod|cDNA cDNA|compound|END_ENTITY	A-type potassium channels expressed from Shaker locus cDNA .
2484347	0	potassium	25,34	Shaker	57,63	potassium	Shaker	MESH:D011188	32780(Tax:7227)	Chemical	Gene	channels|compound|START_ENTITY Properties|nmod|channels expressed|nsubj|Properties expressed|nmod|Drosophila Drosophila|compound|END_ENTITY	Properties of ShB A-type potassium channels expressed in Shaker mutant Drosophila by germline transformation .
3272175	0	potassium	66,75	Shaker	36,42	potassium	Shaker	MESH:D011188	32780(Tax:7227)	Chemical	Gene	contribute|xcomp|START_ENTITY contribute|nsubj|products products|nmod|gene gene|compound|END_ENTITY	Multiple products of the Drosophila Shaker gene may contribute to potassium channel diversity .
3272184	0	potassium	88,97	Shaker	26,32	potassium	Shaker	MESH:D011188	32780(Tax:7227)	Chemical	Gene	currents|compound|START_ENTITY induce|dobj|currents induce|nsubj|clones clones|nmod|locus locus|compound|END_ENTITY	Four cDNA clones from the Shaker locus of Drosophila induce kinetically distinct A-type potassium currents in Xenopus oocytes .
8722559	0	potassium	52,61	Shaker	45,51	potassium	Shaker	MESH:D011188	32780(Tax:7227)	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Unidirectional K + fluxes through recombinant Shaker potassium channels expressed in single Xenopus oocytes .
9110258	0	potassium	47,56	Shaker	40,46	potassium	Shaker	MESH:D011188	32780(Tax:7227)	Chemical	Gene	transcripts|compound|START_ENTITY transcripts|compound|END_ENTITY	Tissue-specific alternative splicing of Shaker potassium channel transcripts results from distinct modes of regulating 3 ' splice choice .
10962171	0	potassium	19,28	Shal	14,18	potassium	Shal	MESH:D011188	16506(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Expression of Shal potassium channel subunits in the adult and developing cochlear nucleus of the mouse .
7891132	0	potassium	83,92	Shal	40,44	potassium	Shal	MESH:D011188	40129(Tax:7227)	Chemical	Gene	currents|compound|START_ENTITY encode|dobj|currents encode|nsubj|END_ENTITY	Genetic analysis of Drosophila neurons : Shal , Shaw , and Shab encode most embryonic potassium currents .
18509535	0	potassium	21,30	Shaw	16,20	potassium	Shaw	MESH:D011188	33599(Tax:7227)	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Function of the Shaw potassium channel within the Drosophila circadian clock .
16513649	0	potassium	75,84	Sk2	94,97	potassium	Sk2	MESH:D011188	3781	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Regulation of surface localization of the small conductance Ca2 + - activated potassium channel , Sk2 , through direct phosphorylation by cAMP-dependent protein kinase .
12442315	0	potassium	26,35	Slack	20,25	potassium	Slack	MESH:D011188	60444(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Localization of the Slack potassium channel in the rat central nervous system .
15708472	0	potassium	78,87	Slack	37,42	potassium	Slack	MESH:D011188	57582	Chemical	Gene	channel|compound|START_ENTITY sequence|nmod|channel END_ENTITY|dep|sequence	Direct binding of estradiol enhances Slack -LRB- sequence like a calcium-activated potassium channel -RRB- channels ' activity .
19540251	0	potassium	67,76	Slack	44,49	potassium	Slack	MESH:D011188	57582	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	cAMP-dependent kinase does not modulate the Slack sodium-activated potassium channel .
14684870	0	potassium	50,59	Slick	0,5	potassium	Slick	MESH:D011188	343450	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|appos|channel	Slick -LRB- Slo2 .1 -RRB- , a rapidly-gating sodium-activated potassium channel inhibited by ATP .
17989352	0	potassium	55,64	Slo1	32,36	potassium	Slo1	MESH:D011188	3778	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	A novel actin-binding domain on Slo1 calcium-activated potassium channels is necessary for their expression in the plasma membrane .
20051533	0	potassium	138,147	Slo1	115,119	potassium	Slo1	MESH:D011188	3778	Chemical	Gene	variant|compound|START_ENTITY variant|amod|END_ENTITY	Dominant-negative regulation of cell surface expression by a pentapeptide motif at the extreme COOH terminus of an Slo1 calcium-activated potassium channel splice variant .
24137539	0	potassium	22,31	Slo1	0,4	potassium	Slo1	MESH:D011188	3778	Chemical	Gene	channel|compound|START_ENTITY channel|nsubj|END_ENTITY	Slo1 is the principal potassium channel of human spermatozoa .
17074977	0	potassium	118,127	Slob	68,72	potassium	Slob	MESH:D011188	34038(Tax:7227)	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|nmod|channel	Mechanisms of two modulatory actions of the channel-binding protein Slob on the Drosophila Slowpoke calcium-dependent potassium channel .
17634402	0	potassium	35,44	Smad7	89,94	potassium	Smad7	MESH:D011188	81516(Tax:10116)	Chemical	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Renal_inflammation is modulated by potassium in chronic_kidney_disease : possible role of Smad7 .
12514204	0	potassium	36,45	Src	58,61	potassium	Src	MESH:D011188	83805(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|nmod|END_ENTITY	Subunit-specific modulation of KCNQ potassium channels by Src tyrosine kinase .
15158164	0	potassium	21,30	Substance_P	0,11	potassium	Substance P	MESH:D011188	21333(Tax:10090)	Chemical	Gene	currents|compound|START_ENTITY inhibits|dobj|currents inhibits|nsubj|END_ENTITY	Substance_P inhibits potassium and calcium currents in inner ear spiral ganglion neurons .
11733509	0	potassium	83,92	TASK-1	49,55	potassium	TASK-1	MESH:D011188	3777	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Formation of functional heterodimers between the TASK-1 and TASK-3 two-pore domain potassium channel subunits .
11886861	0	potassium	48,57	TASK-1	14,20	potassium	TASK-1	MESH:D011188	3777	Chemical	Gene	START_ENTITY|nsubj|Modulation Modulation|nmod|END_ENTITY	Modulation of TASK-1 -LRB- Kcnk3 -RRB- and TASK-3 -LRB- Kcnk9 -RRB- potassium channels : volatile anesthetics and neurotransmitters share a molecular site of action .
19777211	0	potassium	34,43	TASK-1	26,32	potassium	TASK-1	MESH:D011188	3777	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|dep|channel	The human cardiac K2P3 .1 -LRB- TASK-1 -RRB- potassium leak channel is a molecular target for the class III antiarrhythmic drug amiodarone .
21362619	0	potassium	27,36	TASK-1	82,88	potassium	TASK-1	MESH:D011188	3777	Chemical	Gene	blocker|compound|START_ENTITY defines|nsubj|blocker defines|dobj|structure structure|nmod|pore pore|amod|open open|amod|END_ENTITY	A specific two-pore domain potassium channel blocker defines the structure of the TASK-1 open pore .
22977011	0	potassium	143,152	TASK-1	40,46	potassium	TASK-1	MESH:D011188	29553(Tax:10116)	Chemical	Gene	TASK-1|compound|START_ENTITY inhibited|nsubj|TASK-1 mediated|parataxis|inhibited mediated|nsubjpass|inhibition inhibition|nmod|END_ENTITY	The inhibition of the potassium channel TASK-1 in rat cardiac muscle by endothelin-1 is mediated by phospholipase C. AIMS : The two-pore-domain potassium channel TASK-1 is robustly inhibited by the activation of receptors coupled to the Ga -LRB- q -RRB- subgroup of G-proteins , but the signal transduction pathway is still unclear .
23460565	0	potassium	46,55	TASK-1	0,6	potassium	TASK-1	MESH:D011188	29553(Tax:10116)	Chemical	Gene	antagonists|compound|START_ENTITY stimulate|nsubj|antagonists pore|ccomp|stimulate pore|nsubj|END_ENTITY	TASK-1 -LRB- KCNK3 -RRB- and TASK-3 -LRB- KCNK9 -RRB- tandem pore potassium channel antagonists stimulate breathing in isoflurane-anesthetized rats .
24374141	0	potassium	41,50	TASK-1	60,66	potassium	TASK-1	MESH:D011188	3777	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Genetic variation in the two-pore domain potassium channel , TASK-1 , may contribute to an atrial substrate for arrhythmogenesis .
24952150	0	potassium	72,81	TASK-1	64,70	potassium	TASK-1	MESH:D011188	3777	Chemical	Gene	channels|compound|START_ENTITY channels|appos|END_ENTITY	Cloning , functional characterization , and remodeling of K2P3 .1 -LRB- TASK-1 -RRB- potassium channels in a porcine model of atrial_fibrillation and heart_failure .
25017033	0	potassium	46,55	TASK-1	39,45	potassium	TASK-1	MESH:D011188	3777	Chemical	Gene	START_ENTITY|nsubj|inhibitors inhibitors|nmod|END_ENTITY	Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold .
25559843	0	potassium	77,86	TASK-1	96,102	potassium	TASK-1	MESH:D011188	3777	Chemical	Gene	channels|compound|START_ENTITY traffic|nmod|channels interactions|nmod|traffic role|nmod|interactions role|amod|END_ENTITY	The role of protein-protein interactions in the intracellular traffic of the potassium channels TASK-1 and TASK-3 .
11249964	0	potassium	79,88	TASK-3	37,43	potassium	TASK-3	MESH:D011188	51305	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|appos|channel	Functional characterisation of human TASK-3 , an acid-sensitive two-pore domain potassium channel .
11875121	0	potassium	32,41	TASK-3	0,6	potassium	TASK-3	MESH:D011188	84429(Tax:10116)	Chemical	Gene	conductance|compound|START_ENTITY dominates|dobj|conductance dominates|nsubj|END_ENTITY	TASK-3 dominates the background potassium conductance in rat adrenal glomerulosa cells .
12606773	0	potassium	30,39	TASK-3	23,29	potassium	TASK-3	MESH:D011188	51305	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Ruthenium red inhibits TASK-3 potassium channel by interconnecting glutamate 70 of the two subunits .
17728447	0	potassium	23,32	TASK-3	0,6	potassium	TASK-3	MESH:D011188	51305	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	TASK-3 two-pore domain potassium channels enable sustained high-frequency firing in cerebellar granule neurons .
19805135	0	potassium	30,39	TASK-3	23,29	potassium	TASK-3	MESH:D011188	223604(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	An unexpected role for TASK-3 potassium channels in network oscillations with implications for sleep mechanisms and anesthetic action .
21916012	0	potassium	74,83	TASK-3	100,106	potassium	TASK-3	MESH:D011188	51305	Chemical	Gene	antagonist|nmod|START_ENTITY Discovery|nmod|antagonist channel|nsubj|Discovery channel|dobj|.1 .1|appos|END_ENTITY	Discovery of a pharmacologically active antagonist of the two-pore-domain potassium channel K2P9 .1 -LRB- TASK-3 -RRB- .
22147752	0	potassium	100,109	TASK-3	73,79	potassium	TASK-3	MESH:D011188	84429(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Covalent modification of a volatile anesthetic regulatory site activates TASK-3 -LRB- KCNK9 -RRB- tandem-pore potassium channels .
23564779	0	potassium	60,69	TASK-3	85,91	potassium	TASK-3	MESH:D011188	51305	Chemical	Gene	KCNK9|compound|START_ENTITY significance|nmod|KCNK9 significance|appos|END_ENTITY	Expression and prognostic significance of the oncogenic K2P potassium channel KCNK9 -LRB- TASK-3 -RRB- in ovarian_carcinoma .
25199828	0	potassium	69,78	TASK-3	62,68	potassium	TASK-3	MESH:D011188	223604(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Ion channel profile of TRPM8 cold receptors reveals a role of TASK-3 potassium channels in thermosensation .
25318378	0	potassium	20,29	TASK-3	39,45	potassium	TASK-3	MESH:D011188	51305	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Silencing the KCNK9 potassium channel -LRB- TASK-3 -RRB- gene disturbs mitochondrial function , causes mitochondrial depolarization , and induces apoptosis of human melanoma cells .
18034154	0	potassium	22,31	TASK1	16,21	potassium	TASK1	MESH:D011188	16527(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Invalidation of TASK1 potassium channels disrupts adrenal gland zonation and mineralocorticoid homeostasis .
18034154	1	potassium	160,169	TASK1	108,113	potassium	TASK1	MESH:D011188	16527(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY channels|nsubj|END_ENTITY	TASK1 -LRB- KCNK3 -RRB- and TASK3 -LRB- KCNK9 -RRB- are two-pore domain potassium channels highly expressed in adrenal glands .
18824070	0	potassium	47,56	TASK1	31,36	potassium	TASK1	MESH:D011188	3777	Chemical	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Altered neuronal expression of TASK1 and TASK3 potassium channels in rodent and human autoimmune CNS inflammation .
18930826	0	potassium	39,48	TASK1	57,62	potassium	TASK1	MESH:D011188	16527(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY impact|nmod|channel END_ENTITY|nsubj|impact	The neuroprotective impact of the leak potassium channel TASK1 on stroke development in mice .
20049674	0	potassium	16,25	TASK1	0,5	potassium	TASK1	MESH:D011188	16527(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	TASK1 and TASK3 potassium channels : determinants of aldosterone secretion and adrenocortical zonation .
12860925	0	potassium	14,23	TASK2	8,13	potassium	TASK2	MESH:D011188	16529(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of TASK2 potassium channels regarding volume regulation in primary cultures of mouse proximal tubules .
17374744	0	potassium	55,64	TASK3	33,38	potassium	TASK3	MESH:D011188	223604(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY channels|nummod|END_ENTITY	G -LRB- alpha -RRB- q-mediated regulation of TASK3 two-pore domain potassium channels : the role of protein_kinase_C .
17828294	0	potassium	56,65	TASK3	34,39	potassium	TASK3	MESH:D011188	51305	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Identification of a region in the TASK3 two pore domain potassium channel that is critical for its blockade by methanandamide .
18217213	0	potassium	20,29	TASK3	38,43	potassium	TASK3	MESH:D011188	51305	Chemical	Gene	death|compound|START_ENTITY death|compound|END_ENTITY	The two-pore domain potassium channel TASK3 functionally impacts glioma cell death .
20607593	0	potassium	88,97	TASK3	108,113	potassium	TASK3	MESH:D011188	84429(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|channels channels|dep|END_ENTITY	Identification of endocrine cells of the stomach that express acid-sensitive background potassium -LRB- K -LRB- 2P -RRB- 9.1 / TASK3 -RRB- channels .
20646278	0	potassium	16,25	TASK3	76,81	potassium	TASK3	MESH:D011188	223604(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY channels|dep|focus focus|nmod|.1 .1|appos|END_ENTITY	Two pore domain potassium channels in cerebral_ischemia : a focus on K2P9 .1 -LRB- TASK3 , KCNK9 -RRB- .
24307172	0	potassium	164,173	TASK3	64,69	potassium	TASK3	MESH:D011188	51305	Chemical	Gene	channels|compound|START_ENTITY responsible|nsubj|channels responsible|dep|TASK3 TASK3|dep|activity activity|dep|Enhancement Enhancement|nmod|TWIK-related_acid-sensitive_potassium_channel_3 TWIK-related_acid-sensitive_potassium_channel_3|appos|END_ENTITY	Enhancement of TWIK-related_acid-sensitive_potassium_channel_3 -LRB- TASK3 -RRB- two-pore domain potassium channel activity by tumor necrosis factor a. TASK3 two-pore domain potassium -LRB- K2P -RRB- channels are responsible for native leak K channels in many cell types which regulate cell resting membrane potential and excitability .
24307172	0	potassium	87,96	TASK3	64,69	potassium	TASK3	MESH:D011188	51305	Chemical	Gene	activity|compound|START_ENTITY activity|dep|Enhancement Enhancement|nmod|TWIK-related_acid-sensitive_potassium_channel_3 TWIK-related_acid-sensitive_potassium_channel_3|appos|END_ENTITY	Enhancement of TWIK-related_acid-sensitive_potassium_channel_3 -LRB- TASK3 -RRB- two-pore domain potassium channel activity by tumor necrosis factor a. TASK3 two-pore domain potassium -LRB- K2P -RRB- channels are responsible for native leak K channels in many cell types which regulate cell resting membrane potential and excitability .
24342771	0	potassium	42,51	TASK3	36,41	potassium	TASK3	MESH:D011188	51305	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Recovery of current through mutated TASK3 potassium channels underlying Birk Barel syndrome .
11146066	0	potassium	61,70	TNFalpha	24,32	potassium	TNFalpha	MESH:D011188	7124	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|expression expression|compound|END_ENTITY	Inhibition of astrocyte TNFalpha expression by extracellular potassium .
10555144	0	potassium	48,57	TOK1	43,47	potassium	TOK1	MESH:D011188	853352(Tax:4932)	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dep|channels	A molecular target for viral killer toxin : TOK1 potassium channels .
23285272	0	potassium	18,27	TRAAK	12,17	potassium	TRAAK	MESH:D011188	16528(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Deletion of TRAAK potassium channel affects brain metabolism and protects against ischemia .
10784345	0	potassium	86,95	TREK-1	79,85	potassium	TREK-1	MESH:D011188	16526(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|expression expression|nmod|orthologue orthologue|nmod|END_ENTITY	Cloning , localisation and functional expression of the human orthologue of the TREK-1 potassium channel .
11301200	0	potassium	57,66	TREK-1	31,37	potassium	TREK-1	MESH:D011188	170899(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|appos|channel	Distribution and expression of TREK-1 , a two-pore-domain potassium channel , in the adult rat CNS .
15486012	0	potassium	57,66	TREK-1	50,56	potassium	TREK-1	MESH:D011188	3776	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	The effects of hypoxia on the modulation of human TREK-1 potassium channels .
15685212	0	potassium	40,49	TREK-1	59,65	potassium	TREK-1	MESH:D011188	3776	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Inhibition of the human two-pore domain potassium channel , TREK-1 , by fluoxetine and its metabolite norfluoxetine .
16006563	0	potassium	97,106	TREK-1	79,85	potassium	TREK-1	MESH:D011188	3776	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Sequential phosphorylation mediates receptor - and kinase-induced inhibition of TREK-1 background potassium channels .
16711001	0	potassium	43,52	TREK-1	61,67	potassium	TREK-1	MESH:D011188	170899(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY Changes|nmod|expression channel|nsubj|Changes channel|dobj|mRNA mRNA|compound|END_ENTITY	Changes of expression of stretch-activated potassium channel TREK-1 mRNA and protein in hypertrophic_myocardium .
16906152	0	potassium	27,36	TREK-1	45,51	potassium	TREK-1	MESH:D011188	16526(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|results results|compound|END_ENTITY	Deletion of the background potassium channel TREK-1 results in a depression-resistant phenotype .
17556656	0	potassium	69,78	TREK-1	62,68	potassium	TREK-1	MESH:D011188	16526(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Polyunsaturated_fatty_acids are cerebral vasodilators via the TREK-1 potassium channel .
20022044	0	potassium	15,24	TREK-1	8,14	potassium	TREK-1	MESH:D011188	16526(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of TREK-1 potassium channel in bladder_overactivity after partial bladder_outlet_obstruction in mouse .
20357027	0	potassium	51,60	TREK-1	70,76	potassium	TREK-1	MESH:D011188	16526(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY deficient|nmod|channel deficient|xcomp|END_ENTITY	Cerebrovascular responses in mice deficient in the potassium channel , TREK-1 .
21069514	0	potassium	118,127	TREK-1	137,143	potassium	TREK-1	MESH:D011188	3776	Chemical	Gene	vitro|nmod|START_ENTITY channel|amod|vitro neurogenesis|nmod|channel attenuates|nmod|neurogenesis attenuates|xcomp|END_ENTITY	Fluoxetine attenuates the inhibitory effect of glucocorticoid hormones on neurogenesis in vitro via a two-pore domain potassium channel , TREK-1 .
21789545	0	potassium	43,52	TREK-1	61,67	potassium	TREK-1	MESH:D011188	170899(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|expression expression|compound|END_ENTITY	Changes in lipid-sensitive two-pore domain potassium channel TREK-1 expression and its involvement in astrogliosis following cerebral_ischemia in rats .
23271285	0	potassium	57,66	TREK-1	50,56	potassium	TREK-1	MESH:D011188	3776	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Small RNA interference-mediated gene silencing of TREK-1 potassium channel in cultured astrocytes .
23797625	0	potassium	96,105	TREK-1	115,121	potassium	TREK-1	MESH:D011188	3776	Chemical	Gene	effects|appos|START_ENTITY channel|nsubj|effects channel|xcomp|END_ENTITY	The inhibitory effects of bupivacaine , levobupivacaine , and ropivacaine on K2P -LRB- two-pore domain potassium -RRB- channel TREK-1 .
24196565	0	potassium	40,49	TREK-1	137,143	potassium	TREK-1	MESH:D011188	3776	Chemical	Gene	TREK-1|compound|START_ENTITY variant|nmod|TREK-1 reduces|nsubj|variant reduces|dobj|expression expression|nmod|channels channels|compound|END_ENTITY	A splice variant of the two-pore domain potassium channel TREK-1 with only one pore domain reduces the surface expression of full-length TREK-1 channels .
24402080	0	potassium	52,61	TREK-1	70,76	potassium	TREK-1	MESH:D011188	170899(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|synthesis synthesis|amod|related related|amod|END_ENTITY	Electrophysiology and pharmacology of tandem domain potassium channel TREK-1 related BDNF synthesis in rat astrocytes .
24705172	0	potassium	27,36	TREK-1	20,26	potassium	TREK-1	MESH:D011188	170899(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|study study|nmod|END_ENTITY	Functional study of TREK-1 potassium channels during rat heart development and cardiac_ischemia using RNAi techniques .
24801307	0	potassium	104,113	TREK-1	58,64	potassium	TREK-1	MESH:D011188	3776	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|dep|channel	Response of the human detrusor to stretch is regulated by TREK-1 , a two-pore-domain -LRB- K2P -RRB- mechano-gated potassium channel .
25409575	0	potassium	64,73	TREK-1	28,34	potassium	TREK-1	MESH:D011188	16526(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY background|dobj|channels background|nsubj|sensitivity sensitivity|nmod|END_ENTITY	Differential sensitivity of TREK-1 , TREK-2 and TRAAK background potassium channels to the polycationic dye ruthenium red .
25962960	0	potassium	42,51	TREK-1	31,37	potassium	TREK-1	MESH:D011188	3776	Chemical	Gene	START_ENTITY|nsubj|significance significance|nmod|K2P K2P|compound|END_ENTITY	Prognostic significance of the TREK-1 K2P potassium channels in prostate_cancer .
15857947	0	potassium	22,31	TREK-2	15,21	potassium	TREK-2	MESH:D011188	446288(Tax:8355)	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Zinc activates TREK-2 potassium channel activity .
17689202	0	potassium	57,66	TREK-2	38,44	potassium	TREK-2	MESH:D011188	54207	Chemical	Gene	channel|compound|START_ENTITY advance|dep|channel advance|nmod|END_ENTITY	Recent advance and possible future in TREK-2 : a two-pore potassium channel may involved in the process of NPP , brain_ischemia and memory_impairment .
17347672	0	potassium	104,113	TREK1	98,103	potassium	TREK1	MESH:D011188	16526(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Altered acetylcholine , bradykinin and cutaneous pressure-induced vasodilation in mice lacking the TREK1 potassium channel : the endothelial link .
19667202	0	potassium	71,80	TREK1	55,60	potassium	TREK1	MESH:D011188	3776	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Extracellular acidification exerts opposite actions on TREK1 and TREK2 potassium channels via a single conserved histidine residue .
24509840	0	potassium	84,93	TREK1	78,83	potassium	TREK1	MESH:D011188	3776	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Influence of the N terminus on the biophysical properties and pharmacology of TREK1 potassium channels .
25239074	0	potassium	18,27	TREK2	12,17	potassium	TREK2	MESH:D011188	72258(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Role of the TREK2 potassium channel in cold and warm thermosensation and in pain perception .
17962323	0	potassium	83,92	TRESK	0,5	potassium	TRESK	MESH:D011188	332396(Tax:10090)	Chemical	Gene	currents|compound|START_ENTITY component|nmod|currents constitute|dobj|component constitute|nsubj|channels channels|nummod|END_ENTITY	TRESK two-pore-domain K + channels constitute a significant component of background potassium currents in murine dorsal root ganglion neurones .
20871611	0	potassium	42,51	TRESK	36,41	potassium	TRESK	MESH:D011188	338567	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	A dominant-negative mutation in the TRESK potassium channel is linked to familial_migraine_with_aura .
21042202	0	potassium	88,97	TRESK	110,115	potassium	TRESK	MESH:D011188	332396(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY mice|nmod|channel sensitivity|nmod|mice change|nmod|sensitivity END_ENTITY|nsubj|change	Discrete change in volatile anesthetic sensitivity in mice with inactivated tandem pore potassium ion channel TRESK .
21855646	0	potassium	37,46	TRESK	22,27	potassium	TRESK	MESH:D011188	338567	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Migraine : Role of the TRESK two-pore potassium channel .
22115960	0	potassium	42,51	TRESK	0,5	potassium	TRESK	MESH:D011188	338567	Chemical	Gene	channels|compound|START_ENTITY ranger|nmod|channels END_ENTITY|dep|ranger	TRESK : the lone ranger of two-pore domain potassium channels .
11158535	0	potassium	15,24	TRH1	0,4	potassium	TRH1	MESH:D011188	828464(Tax:3702)	Chemical	Gene	transporter|compound|START_ENTITY encodes|dobj|transporter encodes|nsubj|END_ENTITY	TRH1 encodes a potassium transporter required for tip growth in Arabidopsis root hairs .
12101003	0	potassium	39,48	TRK1	68,72	potassium	TRK1	MESH:D011188	853312(Tax:4932)	Chemical	Gene	mechanism|nmod|START_ENTITY analysis|nmod|mechanism uptake|nsubj|analysis uptake|nmod|transporter transporter|compound|END_ENTITY	Molecular analysis of the mechanism of potassium uptake through the TRK1 transporter of Saccharomyces_cerevisiae .
16823886	0	potassium	10,19	TRK1	63,67	potassium	TRK1	MESH:D011188	853312(Tax:4932)	Chemical	Gene	TRK2|compound|START_ENTITY able|nsubj|TRK2 able|xcomp|substitute substitute|nmod|END_ENTITY	The yeast potassium transporter TRK2 is able to substitute for TRK1 in its biological function under low K and low pH conditions .
8282703	0	potassium	27,36	TRK2	0,4	potassium	TRK2	MESH:D011188	853924(Tax:4932)	Chemical	Gene	transporter|compound|START_ENTITY transporter|nsubj|END_ENTITY	TRK2 is not a low-affinity potassium transporter in Saccharomyces_cerevisiae .
25323322	0	potassium	100,109	TRPM4	0,5	potassium	TRPM4	MESH:D011188	171143(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|nummod|END_ENTITY	TRPM4 inhibitor 9-phenanthrol activates endothelial cell intermediate conductance calcium-activated potassium channels in rat isolated mesenteric artery .
19279249	0	potassium	111,120	TRPM8	97,102	potassium	TRPM8	MESH:D011188	171382(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Variable threshold of trigeminal cold-thermosensitive neurons is determined by a balance between TRPM8 and Kv1 potassium channels .
25199828	0	potassium	69,78	TRPM8	23,28	potassium	TRPM8	MESH:D011188	171382(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY role|nmod|channels reveals|dobj|role reveals|nsubj|profile profile|nmod|receptors receptors|nummod|END_ENTITY	Ion channel profile of TRPM8 cold receptors reveals a role of TASK-3 potassium channels in thermosensation .
16889902	0	potassium	35,44	TRPV1	103,108	potassium	TRPV1	MESH:D011188	83810(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY Co-expression|nmod|channel Kv1|nsubj|Co-expression Kv1|nmod|channels channels|appos|END_ENTITY	Co-expression of the voltage-gated potassium channel Kv1 .4 with transient receptor potential channels -LRB- TRPV1 and TRPV2 -RRB- and the cannabinoid receptor CB1 in rat dorsal root ganglion neurons .
23470198	0	potassium	124,133	TRPV1	91,96	potassium	TRPV1	MESH:D011188	7442	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	The ruthenium_NO donor , -LSB- Ru -LRB- bpy -RRB- 2 -LRB- NO -RRB- SO3 -RSB- -LRB- PF6 -RRB- , inhibits inflammatory_pain : involvement of TRPV1 and cGMP/PKG/ATP-sensitive potassium channel signaling pathway .
20133877	0	potassium	6,15	Task2	0,5	potassium	Task2	MESH:D011188	16529(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Task2 potassium channels set central respiratory CO2 and O2 sensitivity .
22878402	0	potassium	6,15	Task3	0,5	potassium	Task3	MESH:D011188	223604(Tax:10090)	Chemical	Gene	invalidation|compound|START_ENTITY invalidation|compound|END_ENTITY	Task3 potassium channel gene invalidation causes low renin and salt-sensitive arterial hypertension .
23698720	0	potassium	44,53	Task3	38,43	potassium	Task3	MESH:D011188	223604(Tax:10090)	Chemical	Gene	mice|compound|START_ENTITY mice|compound|END_ENTITY	Severe hyperaldosteronism in neonatal Task3 potassium channel knockout mice is associated with activation of the intraadrenal renin-angiotensin system .
12225850	0	potassium	94,103	Trk1	87,91	potassium	Trk1	MESH:D011188	853312(Tax:4932)	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	The yeast SR protein kinase Sky1p modulates salt tolerance , membrane potential and the Trk1 ,2 potassium transporter .
16166647	0	potassium	56,65	Trk1	51,55	potassium	Trk1	MESH:D011188	853312(Tax:4932)	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	pH-Responsive , posttranslational regulation of the Trk1 potassium transporter by the type 1-related Ppz1 phosphatase .
24021239	0	potassium	115,124	Trk1	33,37	potassium	Trk1	MESH:D011188	853312(Tax:4932)	Chemical	Gene	levels|compound|START_ENTITY changes|nmod|levels potassium|nmod|changes potassium|nsubj|Role Role|nmod|END_ENTITY	Role of Saccharomyces_cerevisiae Trk1 in stabilization of intracellular potassium content upon changes in external potassium levels .
24021239	0	potassium	72,81	Trk1	33,37	potassium	Trk1	MESH:D011188	853312(Tax:4932)	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of Saccharomyces_cerevisiae Trk1 in stabilization of intracellular potassium content upon changes in external potassium levels .
26019147	0	potassium	46,55	Trk1	25,29	potassium	Trk1	MESH:D011188	853312(Tax:4932)	Chemical	Gene	transporter|compound|START_ENTITY transporter|nsubj|END_ENTITY	Zygosaccharomyces_rouxii Trk1 is an efficient potassium transporter providing yeast cells with high lithium tolerance .
26019147	0	potassium	46,55	Trk1	25,29	potassium	Trk1	MESH:D011188	853312(Tax:4932)	Chemical	Gene	transporter|compound|START_ENTITY transporter|nsubj|END_ENTITY	Zygosaccharomyces_rouxii Trk1 is an efficient potassium transporter providing yeast cells with high lithium tolerance .
12684455	0	potassium	40,49	UNC-103	23,30	potassium	UNC-103	MESH:D011188	175527(Tax:6239)	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Caenorhabditis_elegans UNC-103 ERG-like potassium channel regulates contractile behaviors of sex muscles in males before and during mating .
16775035	0	potassium	44,53	WNK4	77,81	potassium	WNK4	MESH:D011188	65266	Chemical	Gene	independent|compound|START_ENTITY independent|nmod|END_ENTITY	WNK1 affects surface expression of the ROMK potassium channel independent of WNK4 .
15528278	0	potassium	71,80	Yotiao	53,59	potassium	Yotiao	MESH:D011188	10142	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|nmod|channel	Regulatory actions of the A-kinase anchoring protein Yotiao on a heart potassium channel downstream of PKA phosphorylation .
23063532	0	potassium	59,68	angiotensin_II	41,55	potassium	angiotensin II	MESH:D011188	24179(Tax:10116)	Chemical	Gene	current|compound|START_ENTITY END_ENTITY|nmod|current	Mechanical stretch reduces the effect of angiotensin_II on potassium current in cardiac ventricular cells of adult Sprague_Dawley_rats .
2475713	0	potassium	22,31	apamin	47,53	potassium	apamin	MESH:D011188	406135(Tax:7460)	Chemical	Gene	conductance|compound|START_ENTITY conductance|nmod|END_ENTITY	Possible increases in potassium conductance by apamin in mammalian ventricular papillary muscles : a comparison with the effects on enzymatically isolated ventricular cells .
16470808	0	potassium	38,47	aquaporin-4	73,84	potassium	aquaporin-4	MESH:D011188	11829(Tax:10090)	Chemical	Gene	kinetics|compound|START_ENTITY slowed|dobj|kinetics slowed|nmod|mice mice|acl|lacking lacking|dobj|channels channels|amod|END_ENTITY	Increased seizure duration and slowed potassium kinetics in mice lacking aquaporin-4 water channels .
17525153	0	potassium	86,95	aquaporin-4	48,59	potassium	aquaporin-4	MESH:D011188	11829(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY Evidence|dep|channels Evidence|nmod|interaction interaction|nmod|channels channels|amod|END_ENTITY	Evidence against functional interaction between aquaporin-4 water channels and Kir4 .1 potassium channels in retinal M ller cells .
22987392	0	potassium	62,71	aquaporin-4	26,37	potassium	aquaporin-4	MESH:D011188	25293(Tax:10116)	Chemical	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Changes in the astrocytic aquaporin-4 and inwardly rectifying potassium channel expression in the brain of the amyotrophic_lateral_sclerosis SOD1 -LRB- G93A -RRB- rat model .
12682056	0	potassium	9,18	arsenate_reductase	44,62	potassium	arsenate reductase	MESH:D011188	13874340	Chemical	Gene	binding|compound|START_ENTITY stabilizes|nsubj|binding stabilizes|dobj|END_ENTITY	Specific potassium binding stabilizes pI258 arsenate_reductase from Staphylococcus_aureus .
11057658	0	potassium	61,70	beta1	22,27	potassium	beta1	MESH:D011188	3779	Chemical	Gene	channel|compound|START_ENTITY subunit|nmod|channel subunit|amod|END_ENTITY	Vasoregulation by the beta1 subunit of the calcium-activated potassium channel .
11852255	0	potassium	93,102	beta1	54,59	potassium	beta1	MESH:D011188	3779	Chemical	Gene	channel|compound|START_ENTITY subunit|nmod|channel subunit|amod|END_ENTITY	Vasoregulation at the molecular level : a role for the beta1 subunit of the calcium-activated potassium -LRB- BK -RRB- channel .
16439573	0	potassium	26,35	beta1	44,49	potassium	beta1	MESH:D011188	3779	Chemical	Gene	subunits|compound|START_ENTITY subunits|amod|END_ENTITY	Analysis of voltage-gated potassium channel beta1 subunits in the porcine neonatal ductus arteriosus .
1681847	0	potassium	59,68	beta_2-adrenoceptor	21,40	potassium	beta 2-adrenoceptor	MESH:D011188	154	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|blockade blockade|amod|END_ENTITY	Effects of selective beta_2-adrenoceptor blockade on serum potassium and exercise performance in normal men .
11972176	0	potassium	43,52	ca1	99,102	potassium	ca1	MESH:D011188	310218(Tax:10116)	Chemical	Gene	glutamate|nmod|START_ENTITY current|amod|glutamate current|nmod|neurons neurons|nmod|sector sector|amod|END_ENTITY	-LSB- Effects of glutamate on transient outward potassium current of dissociated hippocampal neurons in ca1 sector in rats -RSB- .
18923542	0	potassium	30,39	caveolin-1	58,68	potassium	caveolin-1	MESH:D011188	857	Chemical	Gene	channel|compound|START_ENTITY regulation|nmod|channel regulation|nmod|END_ENTITY	The regulation of the cardiac potassium channel -LRB- HERG -RRB- by caveolin-1 .
18039661	0	potassium	103,112	cortactin	126,135	potassium	cortactin	MESH:D011188	2017	Chemical	Gene	channels|compound|START_ENTITY channels|nmod|END_ENTITY	Reversible tyrosine protein phosphorylation regulates large conductance voltage - and calcium-activated potassium channels via cortactin .
1665913	0	potassium	227,236	cytochrome_c	159,171	potassium	cytochrome c	MESH:D011188	54205	Chemical	Gene	ion|compound|START_ENTITY ion|amod|END_ENTITY	Chlorophyll photosensitized electron transfer reactions in lipid vesicles : enhancement in yield of vectorial electron transfer across the bilayer from reduced cytochrome_c to oxidized ferredoxin by addition of valinomycin plus potassium ion .
3532815	0	potassium	58,67	cytoplasmic_protein	17,36	potassium	cytoplasmic protein	MESH:D011188	8548	Chemical	Gene	efflux|compound|START_ENTITY END_ENTITY|nmod|efflux	Involvement of a cytoplasmic_protein in calcium-dependent potassium efflux in red blood cells .
22298003	0	potassium	129,138	dipeptidyl_peptidase_10	68,91	potassium	dipeptidyl peptidase 10	MESH:D011188	57628	Chemical	Gene	channels|compound|START_ENTITY component|nmod|channels END_ENTITY|appos|component	Crystallization and preliminary X-ray diffraction analysis of human dipeptidyl_peptidase_10 -LRB- DPPY -RRB- , a component of voltage-gated potassium channels .
20170975	0	potassium	110,119	disulfide_isomerase	60,79	potassium	disulfide isomerase	MESH:D011188	79770	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Identification of a common autoantigenic epitope of protein disulfide_isomerase , golgin-160 and voltage-gated potassium channel in type 1 diabetes .
11980904	0	potassium	95,104	eag	91,94	potassium	eag	MESH:D011188	32428(Tax:7227)	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Calcium/calmodulin-dependent _ protein_kinase_II phosphorylates and regulates the Drosophila eag potassium channel .
14699099	0	potassium	8,17	eag	4,7	potassium	eag	MESH:D011188	32428(Tax:7227)	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	The eag potassium channel binds and locally activates calcium/calmodulin-dependent protein kinase II .
1840699	0	potassium	11,20	eag	67,70	potassium	eag	MESH:D011188	32428(Tax:7227)	Chemical	Gene	polypeptide|compound|START_ENTITY encoded|nsubj|polypeptide encoded|nmod|locus locus|compound|END_ENTITY	A distinct potassium channel polypeptide encoded by the Drosophila eag locus .
1901818	0	potassium	52,61	eag	30,33	potassium	eag	MESH:D011188	32428(Tax:7227)	Chemical	Gene	channels|compound|START_ENTITY affecting|dobj|channels gene|acl|affecting characterization|dep|gene characterization|nmod|END_ENTITY	Molecular characterization of eag : a gene affecting potassium channels in Drosophila_melanogaster .
19130887	0	potassium	32,41	eag	28,31	potassium	eag	MESH:D011188	32428(Tax:7227)	Chemical	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Alternative splicing of the eag potassium channel gene in Drosophila generates a novel signal transduction scaffolding protein .
8159766	0	potassium	12,21	eag	47,50	potassium	eag	MESH:D011188	32428(Tax:7227)	Chemical	Gene	genes|compound|START_ENTITY family|nmod|genes related|nsubj|family related|xcomp|END_ENTITY	A family of potassium channel genes related to eag in Drosophila and mammals .
10882483	0	potassium	92,101	eag2	41,45	potassium	eag2	MESH:D011188	171146(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY family|nmod|channels expression|dep|family expression|nmod|END_ENTITY	Cloning and functional expression of rat eag2 , a new member of the ether - - go-go family of potassium channels and comparison of its distribution with that of eag1 .
12135768	0	potassium	64,73	eag2	59,63	potassium	eag2	MESH:D011188	27133	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Molecular identification and characterisation of the human eag2 potassium channel .
1422579	0	potassium	101,110	endothelin-1	24,36	potassium	endothelin-1	MESH:D011188	24323(Tax:10116)	Chemical	Gene	openers|compound|START_ENTITY effects|nmod|openers effects|nmod|properties properties|amod|END_ENTITY	Differential effects of endothelin-1 on the vasorelaxant properties of benzopyran and non-benzopyran potassium channel openers .
15924778	0	potassium	33,42	endothelin-1	132,144	potassium	endothelin-1	MESH:D011188	1906	Chemical	Gene	channels|compound|START_ENTITY Regulation|nmod|channels smooth|nsubj|Regulation smooth|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Regulation of calcium-activated potassium channels of mesenteric artery smooth muscle from patients with essential hypertension by endothelin-1 and prostagl E1 -RSB- .
1610355	0	potassium	4,13	endothelin-1	75,87	potassium	endothelin-1	MESH:D011188	24323(Tax:10116)	Chemical	Gene	opener|compound|START_ENTITY opener|dep|labelled labelled|xcomp|END_ENTITY	The potassium channel opener BRL_38227 inhibits binding of -LSB- 125I -RSB- - labelled endothelin-1 to rat cardiac membranes .
22977011	0	potassium	143,152	endothelin-1	72,84	potassium	endothelin-1	MESH:D011188	24323(Tax:10116)	Chemical	Gene	TASK-1|compound|START_ENTITY inhibited|nsubj|TASK-1 mediated|parataxis|inhibited mediated|nsubjpass|inhibition inhibition|nmod|TASK-1 TASK-1|nmod|muscle muscle|nmod|END_ENTITY	The inhibition of the potassium channel TASK-1 in rat cardiac muscle by endothelin-1 is mediated by phospholipase C. AIMS : The two-pore-domain potassium channel TASK-1 is robustly inhibited by the activation of receptors coupled to the Ga -LRB- q -RRB- subgroup of G-proteins , but the signal transduction pathway is still unclear .
22977011	0	potassium	22,31	endothelin-1	72,84	potassium	endothelin-1	MESH:D011188	24323(Tax:10116)	Chemical	Gene	TASK-1|compound|START_ENTITY TASK-1|nmod|muscle muscle|nmod|END_ENTITY	The inhibition of the potassium channel TASK-1 in rat cardiac muscle by endothelin-1 is mediated by phospholipase C. AIMS : The two-pore-domain potassium channel TASK-1 is robustly inhibited by the activation of receptors coupled to the Ga -LRB- q -RRB- subgroup of G-proteins , but the signal transduction pathway is still unclear .
7732750	0	potassium	41,50	endothelin-1	69,81	potassium	endothelin-1	MESH:D011188	403424(Tax:9615)	Chemical	Gene	content|compound|START_ENTITY content|nmod|plasma plasma|amod|END_ENTITY	Effects of a low sodium diet with a high potassium content on plasma endothelin-1 , atrial_natriuretic_peptide and arginine_vasopressin in normal dogs .
8847337	0	potassium	83,92	endothelin-1	28,40	potassium	endothelin-1	MESH:D011188	403424(Tax:9615)	Chemical	Gene	channels|compound|START_ENTITY modulated|nmod|channels modulated|nsubjpass|tone tone|amod|vasoreactivity vasoreactivity|advcl|END_ENTITY	Pulmonary vasoreactivity to endothelin-1 at elevated vascular tone is modulated by potassium channels .
9774177	0	potassium	96,105	endothelin-1	52,64	potassium	endothelin-1	MESH:D011188	396915(Tax:9823)	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Hypoxic pulmonary vasoconstriction in pigs : role of endothelin-1 , prostanoids and ATP-dependent potassium channels .
4080113	0	potassium	9,18	enkephalin	30,40	potassium	enkephalin	MESH:D011188	29237(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|biosynthesis biosynthesis|compound|END_ENTITY	Elevated potassium stimulates enkephalin biosynthesis in bovine chromaffin cells .
15136697	0	potassium	45,54	episodic_ataxia_type_2	13,35	potassium	episodic ataxia type 2	MESH:D011188	773	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|nmod|channel	Treatment of episodic_ataxia_type_2 with the potassium channel blocker 4-aminopyridine .
15235086	0	potassium	29,38	erg	25,28	potassium	erg	MESH:D011188	2078	Chemical	Gene	START_ENTITY|nsubj|modulation modulation|nmod|END_ENTITY	Muscarinic modulation of erg potassium current .
18998156	0	potassium	34,43	erg1	28,32	potassium	erg1	MESH:D011188	3757	Chemical	Gene	channels|compound|START_ENTITY shape|nsubj|channels gene|acl:relcl|shape gene|appos|END_ENTITY	Ether - - gogo-related gene -LRB- erg1 -RRB- potassium channels shape the dark response of horizontal cells in the mammalian retina .
16150441	0	potassium	58,67	ether-a-go-go-related_gene	31,57	potassium	ether-a-go-go-related gene	MESH:D011188	2078	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Propranolol inhibits the human ether-a-go-go-related_gene potassium channels .
16219910	0	potassium	47,56	ether-a-go-go-related_gene	20,46	potassium	ether-a-go-go-related gene	MESH:D011188	2078	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Activation of human ether-a-go-go-related_gene potassium channels by the diphenylurea_1 ,3 - bis - -LRB- 2-hydroxy-5-trifluoromethyl-phenyl -RRB- - urea -LRB- NS1643 -RRB- .
23115170	0	potassium	102,111	fragile_X_mental_retardation_protein	54,90	potassium	fragile X mental retardation protein	MESH:D011188	2332	Chemical	Gene	channels|compound|START_ENTITY Regulation|nmod|channels Regulation|nmod|END_ENTITY	Regulation of neuronal excitability by interaction of fragile_X_mental_retardation_protein with slack potassium channels .
15955806	0	potassium	57,66	glucose-dependent_insulinotropic_polypeptide	78,122	potassium	glucose-dependent insulinotropic polypeptide	MESH:D011188	2695	Chemical	Gene	channel|compound|START_ENTITY channel|nmod|END_ENTITY	A novel mechanism for the suppression of a voltage-gated potassium channel by glucose-dependent_insulinotropic_polypeptide : protein kinase A-dependent endocytosis .
20861393	0	potassium	34,43	gonadotrophin-releasing_hormone	60,91	potassium	gonadotrophin-releasing hormone	MESH:D011188	25194(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|nmod|END_ENTITY	Expression of kv4 .3 voltage-gated potassium channels in rat gonadotrophin-releasing_hormone -LRB- GnRH -RRB- neurons during the estrous cycle .
21438014	0	potassium	29,38	gp120	6,11	potassium	gp120	MESH:D011188	155971(Tax:11676)	Chemical	Gene	current|compound|START_ENTITY enhances|dobj|current enhances|nsubj|END_ENTITY	HIV-1 gp120 enhances outward potassium current via CXCR4 and cAMP-dependent protein kinase A signaling in cultured rat microglia .
12522086	0	potassium	30,39	hEAG1	14,19	potassium	hEAG1	MESH:D011188	3756	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of hEAG1 and hERG1 potassium channels by clofilium and its tertiary analogue LY97241 .
17120019	0	potassium	20,29	hEAG1	14,19	potassium	hEAG1	MESH:D011188	3756	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Activation of hEAG1 potassium channels by arachidonic_acid .
22357737	0	potassium	132,141	hEAG1	125,130	potassium	hEAG1	MESH:D011188	3756	Chemical	Gene	channel|compound|START_ENTITY 1|dep|channel 1|appos|END_ENTITY	Regulation of cell proliferation of human induced pluripotent stem cell-derived mesenchymal stem cells via ether - - go-go 1 -LRB- hEAG1 -RRB- potassium channel .
22466864	0	potassium	65,74	hEAG1	58,63	potassium	hEAG1	MESH:D011188	3756	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Frequent aberrant expression of the human ether go-go -LRB- hEAG1 -RRB- potassium channel in head_and_neck_cancer : pathobiological mechanisms and clinical implications .
10651011	0	potassium	119,128	hERG	114,118	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Allosteric effects of mutations in the extracellular S5-P loop on the gating and ion permeation properties of the hERG potassium channel .
12873512	0	potassium	19,28	hERG	14,18	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|dobj|channel	Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods .
15385083	0	potassium	39,48	hERG	34,38	potassium	hERG	MESH:D011188	2078	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|amod|END_ENTITY	Variability in the measurement of hERG potassium channel inhibition : effects of temperature and stimulus pattern .
15494025	0	potassium	63,72	hERG	58,62	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Physical and functional interaction between integrins and hERG potassium channels .
15537500	0	potassium	21,30	hERG	16,20	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dobj|channels	Direct block of hERG potassium channels by the protein_kinase_C inhibitor bisindolylmaleimide_I -LRB- GF109203X -RRB- .
15716081	0	potassium	82,91	hERG	77,81	potassium	hERG	MESH:D011188	2078	Chemical	Gene	currents|compound|START_ENTITY currents|amod|END_ENTITY	Effects of the antiepileptic_drugs lamotrigine , topiramate and gabapentin on hERG potassium currents .
15922632	0	potassium	114,123	hERG	109,113	potassium	hERG	MESH:D011188	2078	Chemical	Gene	current|compound|START_ENTITY current|amod|END_ENTITY	Additive effects of ziprasidone and D,L-sotalol on the action potential in rabbit Purkinje fibres and on the hERG potassium current .
15976038	0	potassium	53,62	hERG	47,51	potassium	hERG	MESH:D011188	2078	Chemical	Gene	START_ENTITY|nsubj|gene gene|appos|END_ENTITY	Novel potent human ether-a-go-go-related gene -LRB- hERG -RRB- potassium channel enhancers and their in vitro antiarrhythmic activity .
15978804	0	potassium	27,36	hERG	22,26	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Predictive models for hERG potassium channel blockers .
16050266	0	potassium	56,65	hERG	51,55	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Structural determinants for high-affinity block of hERG potassium channels .
16051556	0	potassium	37,46	hERG	32,36	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dobj|channels	The phenothiazine drugs inhibit hERG potassium channels .
16426850	0	potassium	19,28	hERG	14,18	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|dobj|channel	Prediction of hERG potassium channel affinity by the CODESSA approach .
16495758	0	potassium	57,66	hERG	52,56	potassium	hERG	MESH:D011188	2078	Chemical	Gene	current|compound|START_ENTITY current|compound|END_ENTITY	Flunarizine is a highly potent inhibitor of cardiac hERG potassium current .
16554806	0	potassium	5,14	hERG	0,4	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dobj|channels	hERG potassium channels and cardiac_arrhythmia .
16736158	0	potassium	81,90	hERG	76,80	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Atypical tetracyclic antidepressant maprotiline is an antagonist at cardiac hERG potassium channels .
16769794	0	potassium	33,42	hERG	28,32	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Na + permeation and block of hERG potassium channels .
16926094	0	potassium	51,60	hERG	46,50	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Orange flavonoid hesperetin modulates cardiac hERG potassium channel via binding to amino_acid F656 .
16928897	0	potassium	62,71	hERG	56,60	potassium	hERG	MESH:D011188	2078	Chemical	Gene	START_ENTITY|nsubj|gene gene|appos|END_ENTITY	Mallotoxin is a novel human ether-a-go-go-related gene -LRB- hERG -RRB- potassium channel activator .
17042915	0	potassium	23,32	hERG	113,117	potassium	hERG	MESH:D011188	2078	Chemical	Gene	concentration|compound|START_ENTITY modulate|nsubj|concentration modulate|dobj|block block|nmod|channels channels|compound|END_ENTITY	Altering extracellular potassium concentration does not modulate drug block of human ether-a-go-go-related gene -LRB- hERG -RRB- channels .
17298291	0	potassium	9,18	hERG	4,8	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	The hERG potassium channel as a therapeutic target .
17363390	0	potassium	19,28	hERG	14,18	potassium	hERG	MESH:D011188	2078	Chemical	Gene	currents|compound|START_ENTITY END_ENTITY|dobj|currents	Modulation of hERG potassium currents in HEK-293 cells by protein_kinase_C .
17444521	0	potassium	23,32	hERG	18,22	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Drug block of the hERG potassium channel : insight from modeling .
17477915	0	potassium	18,27	hERG	13,17	potassium	hERG	MESH:D011188	2078	Chemical	Gene	currents|compound|START_ENTITY END_ENTITY|dobj|currents	Reduction of hERG potassium currents by hyperosmolar solutions .
17624316	0	potassium	56,65	hERG	51,55	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Functional consequences of methionine oxidation of hERG potassium channels .
17823114	0	potassium	26,35	hERG	21,25	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dobj|channels	Activation gating of hERG potassium channels : S6 glycines are not required as gating hinges .
17926340	0	potassium	18,27	hERG	13,17	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Modeling the hERG potassium channel in a phospholipid bilayer : Molecular dynamics and drug docking studies .
17961513	0	potassium	76,85	hERG	71,75	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Green tea flavonoid epigallocatechin-3-gallate -LRB- EGCG -RRB- inhibits cardiac hERG potassium channels .
17982510	0	potassium	31,40	hERG	26,30	potassium	hERG	MESH:D011188	2078	Chemical	Gene	blockade|amod|START_ENTITY END_ENTITY|dobj|blockade	Comparative evaluation of hERG potassium channel blockade by antipsychotics .
18243713	0	potassium	47,56	hERG	42,46	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	A binary QSAR model for classification of hERG potassium channel blockers .
18447395	0	potassium	5,14	hERG	0,4	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dobj|channels	hERG potassium channels and the structural basis of drug-induced arrhythmias .
18458880	0	potassium	27,36	hERG	22,26	potassium	hERG	MESH:D011188	2078	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of cardiac hERG potassium channels by tetracyclic antidepressant mianserin .
18574455	0	potassium	111,120	hERG	105,109	potassium	hERG	MESH:D011188	2078	Chemical	Gene	START_ENTITY|nsubj|gene gene|appos|END_ENTITY	The 5-HT2 antagonist ketanserin is an open channel blocker of human cardiac ether - - go-go-related gene -LRB- hERG -RRB- potassium channels .
18616963	0	potassium	9,18	hERG	4,8	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	The hERG potassium channel and hERG screening for drug-induced torsades_de_pointes .
18849661	0	potassium	13,22	hERG	8,12	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Role of hERG potassium channel assays in drug development .
18998101	0	potassium	15,24	hERG	10,14	potassium	hERG	MESH:D011188	2078	Chemical	Gene	currents|compound|START_ENTITY END_ENTITY|dobj|currents	Recording hERG potassium currents and assessing the effects of compounds using the whole-cell patch-clamp technique .
19034038	0	potassium	48,57	hERG	43,47	potassium	hERG	MESH:D011188	2078	Chemical	Gene	current|compound|START_ENTITY current|amod|END_ENTITY	Effects of common antitussive drugs on the hERG potassium channel current .
19442204	0	potassium	30,39	hERG	25,29	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|dobj|channel	The interactions between hERG potassium channel and blockers .
19534531	0	potassium	65,74	hERG	84,88	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Side chain flexibilities in the human ether-a-go-go related gene potassium channel -LRB- hERG -RRB- together with matched-pair binding studies suggest a new binding mode for channel blockers .
19651618	0	potassium	115,124	hERG	110,114	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	A recombinant N-terminal domain fully restores deactivation gating in N-truncated and long_QT_syndrome mutant hERG potassium channels .
19878047	0	potassium	39,48	hERG	34,38	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Movement of the S4 segment in the hERG potassium channel during membrane depolarization .
19903464	0	potassium	34,43	hERG	29,33	potassium	hERG	MESH:D011188	2078	Chemical	Gene	currents|compound|START_ENTITY currents|amod|END_ENTITY	Block effect of capsaicin on hERG potassium currents is enhanced by S6 mutation at Y652 .
20146282	0	potassium	9,18	hERG	4,8	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	The hERG potassium channel and drug trapping : insight from docking studies with propafenone derivatives .
20172036	0	potassium	50,59	hERG	45,49	potassium	hERG	MESH:D011188	2078	Chemical	Gene	inhibition|amod|START_ENTITY END_ENTITY|dobj|inhibition	Investigating dynamic protocol-dependence of hERG potassium channel inhibition at 37 degrees C : Cisapride versus dofetilide .
20643767	0	potassium	49,58	hERG	44,48	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Revealing the structural basis of action of hERG potassium channel activators and blockers .
21219869	0	potassium	47,56	hERG	42,46	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dobj|channels	Enhanced inhibitory effect of acidosis on hERG potassium channels that incorporate the hERG1b isoform .
21357734	0	potassium	5,14	hERG	0,4	potassium	hERG	MESH:D011188	2078	Chemical	Gene	gating|compound|START_ENTITY gating|amod|END_ENTITY	hERG potassium channel gating is mediated by N - and C-terminal region interactions .
21362439	0	potassium	77,86	hERG	72,76	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Identification of quaternary_ammonium compounds as potent inhibitors of hERG potassium channels .
21489024	0	potassium	39,48	hERG	34,38	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Pharmacological inhibition of the hERG potassium channel is modulated by extracellular but not intracellular acidosis .
21623390	0	potassium	54,63	hERG	48,52	potassium	hERG	MESH:D011188	2078	Chemical	Gene	START_ENTITY|nsubj|Activation Activation|nmod|gene gene|dep|END_ENTITY	Activation of human ether-a-go-go related gene -LRB- hERG -RRB- potassium channels by small molecules .
21777565	0	potassium	182,191	hERG	4,8	potassium	hERG	MESH:D011188	2078	Chemical	Gene	current|compound|START_ENTITY mediating|dobj|current responsible|xcomp|mediating repolarization|dep|responsible characterization|nmod|repolarization channel|dep|characterization channel|amod|END_ENTITY	The hERG K -LRB- + -RRB- channel S4 domain L532P mutation : characterization at 37 C. hERG -LRB- human Ether - - go-go Related Gene -RRB- is responsible for ion channels mediating rapid delayed rectifier potassium current , I -LRB- Kr -RRB- , which is key to cardiac action potential repolarization .
21806934	0	potassium	26,35	hERG	81,85	potassium	hERG	MESH:D011188	2078	Chemical	Gene	Blockade|nmod|START_ENTITY Blockade|nmod|G628S G628S|acl|nonconducting nonconducting|advcl|END_ENTITY	Blockade of permeation by potassium but normal gating of the G628S nonconducting hERG channel mutant .
21844197	0	potassium	92,101	hERG	138,142	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channels|compound|START_ENTITY revealed|nsubj|channels revealed|nmod|+ +|acl|induced induced|xcomp|END_ENTITY	Interaction between the cardiac rapidly -LRB- IKr -RRB- and slowly -LRB- IKs -RRB- activating delayed rectifier potassium channels revealed by low K + - induced hERG endocytic degradation .
21950687	0	potassium	32,41	hERG	27,31	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dobj|channels	High potency inhibition of hERG potassium channels by the sodium-calcium exchange inhibitor KB-R7943 .
21989164	0	potassium	31,40	hERG	26,30	potassium	hERG	MESH:D011188	2078	Chemical	Gene	inhibition|amod|START_ENTITY END_ENTITY|dobj|inhibition	Molecular determinants of hERG potassium channel inhibition by disopyramide .
22052838	0	potassium	55,64	hERG	50,54	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	The solution structure of the S4-S5 linker of the hERG potassium channel .
22101212	0	potassium	23,32	hERG	18,22	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dobj|channels	Curcumin inhibits hERG potassium channels in vitro .
22380484	2	potassium	107,116	hERG	102,106	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Development of binary classification models for prediction of hERG potassium channel blockage .
22609836	0	potassium	108,117	hERG	76,80	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dobj|channels	Comparison of the effects of DC031050 , a class III antiarrhythmic agent , on hERG channel and three neuronal potassium channels .
22684720	1	potassium	389,398	hERG	383,387	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channels|compound|START_ENTITY gene|dep|channels gene|appos|END_ENTITY	In vitro electrophysiological safety studies have become an integral part of the drug development process since , in many instances , compound-induced QT_prolongation has been associated with a direct block of human ether-a-go-go-related gene -LRB- hERG -RRB- potassium channels or its native current , the rapidly activating delayed rectifier potassium current -LRB- I -LRB- Kr -RRB- -RRB- .
22742967	0	potassium	91,100	hERG	12,16	potassium	hERG	MESH:D011188	2078	Chemical	Gene	current|compound|START_ENTITY component|nmod|current basis|nmod|component channels|dep|basis channels|compound|END_ENTITY	Deciphering hERG channels : molecular basis of the rapid component of the delayed rectifier potassium current .
22856456	0	potassium	64,73	hERG	59,63	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Marine algal toxin azaspiracid is an open-state blocker of hERG potassium channels .
23041462	0	potassium	86,95	hERG	81,85	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Purification and structural characterization of the voltage-sensor domain of the hERG potassium channel .
23103595	0	potassium	97,106	hERG	115,119	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channel|compound|START_ENTITY channel|acl|END_ENTITY	Development of a high-throughput electrophysiological assay for the human ether - - go-go related potassium channel hERG .
23133669	0	potassium	32,41	hERG	27,31	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Ion conduction through the hERG potassium channel .
23369369	0	potassium	40,49	hERG	35,39	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Current pharmacogenomic studies on hERG potassium channels .
23423263	0	potassium	45,54	hERG	40,44	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|dobj|channel	Biomimetic membrane platform containing hERG potassium channel and its application to drug screening .
23524574	0	potassium	56,65	hERG	51,55	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dobj|channels	Allocryptopine and benzyltetrahydropalmatine block hERG potassium channels expressed in HEK293 cells .
23711922	0	potassium	81,90	hERG	76,80	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	The synergic modeling for the binding of fluoroquinolone antibiotics to the hERG potassium channel .
23716168	0	potassium	44,53	hERG	39,43	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|dobj|channel	AMP-activated protein kinase regulates hERG potassium channel .
23917377	0	potassium	106,115	hERG	101,105	potassium	hERG	MESH:D011188	3757	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	ZC88 , a novel 4-amino_piperidine analog , inhibits the growth of neuroblastoma cells through blocking hERG potassium channel .
24045971	0	potassium	27,36	hERG	22,26	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Escitalopram block of hERG potassium channels .
24386436	0	potassium	5,14	hERG	0,4	potassium	hERG	MESH:D011188	2078	Chemical	Gene	blockage|compound|START_ENTITY blockage|amod|END_ENTITY	hERG potassium channel blockage by scorpion toxin BmKKx2 enhances erythroid differentiation of human leukemia cells K562 .
24400172	0	potassium	43,52	hERG	38,42	potassium	hERG	MESH:D011188	2078	Chemical	Gene	response|compound|START_ENTITY response|amod|END_ENTITY	Modification by KCNE1 variants of the hERG potassium channel response to premature stimulation and to pharmacological inhibition .
24417241	0	potassium	78,87	hERG	73,77	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Allosteric effects of erythromycin pretreatment on thioridazine block of hERG potassium channels .
24877995	0	potassium	30,39	hERG	25,29	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Ranolazine inhibition of hERG potassium channels : drug-pore interactions and reduced potency against inactivation mutants .
24976154	0	potassium	76,85	hERG	71,75	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Novel Bayesian classification models for predicting compounds blocking hERG potassium channels .
25117629	0	potassium	123,132	hERG	83,87	potassium	hERG	MESH:D011188	2078	Chemical	Gene	START_ENTITY|nsubj|assessment assessment|nmod|assay assay|nmod|END_ENTITY	Solubility assessment and on-line exposure confirmation in a patch-clamp assay for hERG -LRB- human ether-a-go-go-related gene -RRB- potassium channel inhibition .
25318749	0	potassium	106,115	hERG	19,23	potassium	hERG	MESH:D011188	2078	Chemical	Gene	concentration|compound|START_ENTITY Suppression|nmod|concentration Suppression|nmod|response response|amod|END_ENTITY	Suppression of the hERG potassium channel response to premature stimulation by reduction in extracellular potassium concentration .
25318749	0	potassium	24,33	hERG	19,23	potassium	hERG	MESH:D011188	2078	Chemical	Gene	response|compound|START_ENTITY response|amod|END_ENTITY	Suppression of the hERG potassium channel response to premature stimulation by reduction in extracellular potassium concentration .
25331429	0	potassium	71,80	hERG	66,70	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Structural insight into the transmembrane segments 3 and 4 of the hERG potassium channel .
25456079	0	potassium	134,143	hERG	129,133	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Discovery of novel tetrahydroisoquinoline derivatives as orally active N-type calcium channel blockers with high selectivity for hERG potassium channels .
25481375	0	potassium	66,75	hERG	61,65	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dobj|channels	Effects of Chelidonium majus extracts and major alkaloids on hERG potassium channels and on dog cardiac action potential - A safety approach .
25680947	0	potassium	68,77	hERG	63,67	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dobj|channels	Endoxifen , the active metabolite of tamoxifen , inhibits cloned hERG potassium channels .
25800797	0	potassium	81,90	hERG	75,79	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channels|compound|START_ENTITY mediated|dobj|channels mediated|parataxis|END_ENTITY	Hypaconitine-induced QT_prolongation mediated through inhibition of KCNH2 -LRB- hERG -RRB- potassium channels in conscious dogs .
25911606	0	potassium	5,14	hERG	0,4	potassium	hERG	MESH:D011188	2078	Chemical	Gene	blockade|compound|START_ENTITY blockade|amod|END_ENTITY	hERG potassium channel blockade by the HCN channel inhibitor bradycardic agent ivabradine .
26159617	0	potassium	24,33	hERG	19,23	potassium	hERG	MESH:D011188	2078	Chemical	Gene	blockade|amod|START_ENTITY END_ENTITY|dobj|blockade	Molecular basis of hERG potassium channel blockade by the class Ic antiarrhythmic flecainide .
26275355	0	potassium	5,14	hERG	0,4	potassium	hERG	MESH:D011188	2078	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|amod|END_ENTITY	hERG potassium channel inhibition by ivabradine requires channel gating .
26301071	0	potassium	5,14	hERG	0,4	potassium	hERG	MESH:D011188	2078	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|amod|END_ENTITY	hERG potassium channel inhibition by ivabradine may contribute to QT_prolongation and risk of torsades_de_pointes .
26363003	0	potassium	58,67	hERG	52,56	potassium	hERG	MESH:D011188	2078	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|gene gene|appos|END_ENTITY	Regulation of the human ether-a-go-go-related gene -LRB- hERG -RRB- potassium channel by Nedd4 family interacting proteins -LRB- Ndfips -RRB- .
26484507	0	potassium	53,62	hERG	48,52	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Mechanism of inhibition by olanzapine of cloned hERG potassium channels .
26516576	0	potassium	19,28	hERG	14,18	potassium	hERG	MESH:D011188	2078	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|dobj|channel	Inhibition of hERG potassium channel by the antiarrhythmic agent mexiletine and its metabolite m-hydroxymexiletine .
26526230	0	potassium	112,121	hERG	106,110	potassium	hERG	MESH:D011188	2078	Chemical	Gene	photoinduced|dep|START_ENTITY photoinduced|dep|END_ENTITY	Novel intramolecular photoinduced electron transfer-based probe for the Human Ether-a-go-go-Related Gene -LRB- hERG -RRB- potassium channel .
16227340	0	potassium	59,68	hERG1	52,57	potassium	hERG1	MESH:D011188	3757	Chemical	Gene	channels|compound|START_ENTITY KCNH2|dep|channels KCNH2|appos|END_ENTITY	Specific serine proteases selectively damage KCNH2 -LRB- hERG1 -RRB- potassium channels and I -LRB- Kr -RRB- .
19413965	0	potassium	110,119	hERG1	104,109	potassium	hERG1	MESH:D011188	3757	Chemical	Gene	structure|compound|START_ENTITY structure|amod|END_ENTITY	Interactions of H562 in the S5 helix with T618 and S621 in the pore helix are important determinants of hERG1 potassium channel structure and function .
20097192	0	potassium	51,60	hERG1	45,50	potassium	hERG1	MESH:D011188	3757	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	The amiodarone derivative KB130015 activates hERG1 potassium channels via a novel mechanism .
20547678	0	potassium	75,84	hERG1	69,74	potassium	hERG1	MESH:D011188	3757	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Cysteine 723 in the C-linker segment confers oxidative inhibition of hERG1 potassium channels .
21463633	0	potassium	63,72	hERG1	81,86	potassium	hERG1	MESH:D011188	3757	Chemical	Gene	channel|compound|START_ENTITY ubiquitylation|nmod|channel END_ENTITY|nsubj|ubiquitylation	Nedd4-2-dependent ubiquitylation and regulation of the cardiac potassium channel hERG1 .
24830940	0	potassium	116,125	hERG1	109,114	potassium	hERG1	MESH:D011188	3757	Chemical	Gene	START_ENTITY|nsubj|gene gene|appos|END_ENTITY	Long-term channel block is required to inhibit cellular transformation by human ether - - go-go-related gene -LRB- hERG1 -RRB- potassium channels .
15208030	0	potassium	90,99	hIKCa1	110,116	potassium	hIKCa1	MESH:D011188	3783	Chemical	Gene	channels|compound|START_ENTITY channels|appos|END_ENTITY	Block of maurotoxin and charybdotoxin on human intermediate-conductance calcium-activated potassium channels -LRB- hIKCa1 -RRB- .
8821791	0	potassium	83,92	hIRK1	102,107	potassium	hIRK1	MESH:D011188	3768	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Cloning , localization , and functional expression of a human brain inward rectifier potassium channel -LRB- hIRK1 -RRB- .
15707997	0	potassium	27,36	hKCNE4	0,6	potassium	hKCNE4	MESH:D011188	23704	Chemical	Gene	current|compound|START_ENTITY inhibits|dobj|current inhibits|nsubj|END_ENTITY	hKCNE4 inhibits the hKCNQ1 potassium current without affecting the activation kinetics .
15707997	0	potassium	27,36	hKCNQ1	20,26	potassium	hKCNQ1	MESH:D011188	3784	Chemical	Gene	current|compound|START_ENTITY current|amod|END_ENTITY	hKCNE4 inhibits the hKCNQ1 potassium current without affecting the activation kinetics .
10196711	0	potassium	46,55	hSKCa3	38,44	potassium	hSKCa3	MESH:D011188	3782	Chemical	Gene	START_ENTITY|nsubj|evidence evidence|appos|END_ENTITY	No evidence for involvement of KCNN3 -LRB- hSKCa3 -RRB- potassium channel gene in familial and isolated cases of schizophrenia .
10523823	0	potassium	46,55	hSKCa3	69,75	potassium	hSKCa3	MESH:D011188	3782	Chemical	Gene	gene|compound|START_ENTITY association|nmod|gene support|dobj|association evidence|acl|support END_ENTITY|nsubj|evidence	No evidence to support the association of the potassium channel gene hSKCa3 CAG repeat with schizophrenia or bipolar_disorder in the Irish population .
10732800	0	potassium	46,55	hSKCa3	70,76	potassium	hSKCa3	MESH:D011188	3782	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The human small conductance calcium-regulated potassium channel gene -LRB- hSKCa3 -RRB- contains two CAG repeats in exon 1 , is on chromosome 1q21 .3 , and shows a possible association with schizophrenia .
12009018	0	potassium	50,59	hSlo	45,49	potassium	hSlo	MESH:D011188	3778	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Prostaglandin_E2 induces interaction between hSlo potassium channel and Syk tyrosine kinase in osteosarcoma cells .
12223479	0	potassium	86,95	hSlo	63,67	potassium	hSlo	MESH:D011188	3778	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Reciprocal modulation between the alpha and beta 4 subunits of hSlo calcium-dependent potassium channels .
14584897	0	potassium	91,100	hSlo	86,90	potassium	hSlo	MESH:D011188	3778	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Focal adhesion kinase pp125FAK interacts with the large conductance calcium-activated hSlo potassium channel in human osteoblasts : potential role in mechanotransduction .
18404672	0	potassium	18,27	hSlo	13,17	potassium	hSlo	MESH:D011188	3778	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Silencing of hSlo potassium channels in human osteosarcoma cells promotes tumorigenesis .
9829973	0	potassium	64,73	hSlo	75,79	potassium	hSlo	MESH:D011188	3778	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Role of the S4 segment in a voltage-dependent calcium-sensitive potassium -LRB- hSlo -RRB- channel .
18458804	0	potassium	56,65	heag2	36,41	potassium	heag2	MESH:D011188	27133	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Tubulin as a binding partner of the heag2 voltage-gated potassium channel .
8679653	0	potassium	45,54	hsp70	29,34	potassium	hsp70	MESH:D011188	3308	Chemical	Gene	channels|compound|START_ENTITY activates|dobj|channels activates|nsubj|END_ENTITY	Exogenous heat_shock protein hsp70 activates potassium channels in U937 cells .
18536731	1	potassium	164,173	human	132,137	potassium	Kv4.3	MESH:D011188	3752	Chemical	Gene	current|compound|START_ENTITY current|amod|END_ENTITY	BACKGROUND AND PURPOSE : The human cardiac transient outward potassium current -LRB- Ito -RRB- is believed to be composed of the pore-forming Kv4 .3 alpha-subunit , coassembled with modulatory beta-subunits as KChIP2 , MiRP1 and DPP6 proteins .
10482044	0	potassium	49,58	insulin	15,22	potassium	insulin	MESH:D011188	3630	Chemical	Gene	supply|compound|START_ENTITY influence|nmod|supply Measurement|dep|influence Measurement|nmod|sensitivity sensitivity|compound|END_ENTITY	Measurement of insulin sensitivity : influence of potassium supply during euglycaemic_glucose_clamps in healthy volunteers .
11868613	0	potassium	33,42	insulin	85,92	potassium	insulin	MESH:D011188	3630	Chemical	Gene	coupled|nsubjpass|START_ENTITY coupled|nmod|resistance resistance|compound|END_ENTITY	Adenosine_triphosphate-sensitive potassium -LRB- K -LRB- ATP -RRB- -RRB- channel activity is coupled with insulin resistance in obesity and type_2_diabetes_mellitus .
11959047	0	potassium	16,25	insulin	8,15	potassium	insulin	MESH:D011188	3630	Chemical	Gene	infusion|compound|START_ENTITY infusion|compound|END_ENTITY	Glucose insulin potassium infusion improves systolic function in patients with chronic ischemic_cardiomyopathy .
12542400	0	potassium	128,137	insulin	13,20	potassium	insulin	MESH:D011188	3630	Chemical	Gene	channels|compound|START_ENTITY loss|nmod|channels due|nmod|loss due|nsubj|secretion secretion|compound|END_ENTITY	Uncontrolled insulin secretion from a childhood pancreatic beta-cell adenoma is not due to the functional loss of ATP-sensitive potassium channels .
14562192	0	potassium	26,35	insulin	18,25	potassium	insulin	MESH:D011188	3630	Chemical	Gene	infusion|compound|START_ENTITY infusion|compound|END_ENTITY	Long-term glucose insulin potassium infusion improves systolic and diastolic function in patients with chronic ischemic_cardiomyopathy .
15948674	0	potassium	6,15	insulin	51,58	potassium	insulin	MESH:D011188	3630	Chemical	Gene	blockade|compound|START_ENTITY Kv1|dobj|blockade Kv1|nmod|approach approach|nmod|resistance resistance|compound|END_ENTITY	Kv1 .3 potassium channel blockade as an approach to insulin resistance .
1733294	0	potassium	21,30	insulin	10,17	potassium	insulin	MESH:D011188	100009181(Tax:9986)	Chemical	Gene	secretion|compound|START_ENTITY END_ENTITY|nmod|secretion	Effect of insulin on potassium secretion in rabbit cortical collecting ducts .
1793613	0	potassium	26,35	insulin	9,16	potassium	insulin	MESH:D011188	3630	Chemical	Gene	uptake|compound|START_ENTITY mediated|dobj|uptake mediated|nsubj|END_ENTITY	Impaired insulin mediated potassium uptake in adolescents with IDDM .
17968975	0	potassium	24,33	insulin	57,64	potassium	insulin	MESH:D011188	3630	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Insulin effect on serum potassium and auto-inhibition of insulin secretion is intact in a patient with leprechaunism despite severe impairment_of_substrates_metabolism .
1988777	0	potassium	59,68	insulin	20,27	potassium	insulin	MESH:D011188	3630	Chemical	Gene	depend|nmod|START_ENTITY depend|nsubj|retention retention|nmod|END_ENTITY	Sodium retention by insulin may depend on decreased plasma potassium .
21734082	0	potassium	47,56	insulin	14,21	potassium	insulin	MESH:D011188	3630	Chemical	Gene	glucose|nmod|START_ENTITY action|nmod|glucose action|compound|END_ENTITY	Comparison of insulin action on glucose versus potassium uptake in humans .
21946656	0	potassium	22,31	insulin	82,89	potassium	insulin	MESH:D011188	3630	Chemical	Gene	excretion|compound|START_ENTITY Determinants|nmod|excretion Determinants|dep|role role|nmod|therapy therapy|compound|END_ENTITY	Determinants of renal potassium excretion in critically ill patients : the role of insulin therapy .
22550068	0	potassium	64,73	insulin	36,43	potassium	insulin	MESH:D011188	3630	Chemical	Gene	depolarization|compound|START_ENTITY secretion|nmod|depolarization END_ENTITY|acl|secretion	Ca -LRB- 2 + -RRB- - dependent desensitization of insulin secretion by strong potassium depolarization .
4799348	1	potassium	86,95	insulin	26,33	potassium	insulin	MESH:D011188	3630	Chemical	Gene	transfer|compound|START_ENTITY insulin|nmod|transfer effect|nmod|insulin Mode|dep|effect Mode|nmod|action action|compound|END_ENTITY	Mode of insulin action on the cell : separative effect of insulin on potassium and glucose transfer of myocardium .
4799348	1	potassium	86,95	insulin	75,82	potassium	insulin	MESH:D011188	3630	Chemical	Gene	transfer|compound|START_ENTITY END_ENTITY|nmod|transfer	Mode of insulin action on the cell : separative effect of insulin on potassium and glucose transfer of myocardium .
621284	0	potassium	53,62	insulin	19,26	potassium	insulin	MESH:D011188	483665(Tax:9615)	Chemical	Gene	metabolism|compound|START_ENTITY secretion|nmod|metabolism secretion|nsubj|Influence Influence|nmod|END_ENTITY	Influence of basal insulin and glucagon secretion on potassium and sodium metabolism .
6765549	0	potassium	33,42	insulin	96,103	potassium	insulin	MESH:D011188	3630	Chemical	Gene	START_ENTITY|nmod|hypoglycemia hypoglycemia|acl|induced induced|nmod|END_ENTITY	Less pronounced changes in serum potassium and epinephrine during hypoglycemia induced by human insulin -LRB- recombinant DNA -RRB- .
7018811	0	potassium	31,40	insulin	68,75	potassium	insulin	MESH:D011188	3630	Chemical	Gene	disposition|nmod|START_ENTITY disposition|dep|role role|nmod|END_ENTITY	The disposition of intravenous potassium in normal man : the role of insulin .
8736460	0	potassium	45,54	insulin	20,27	potassium	insulin	MESH:D011188	3630	Chemical	Gene	opener|compound|START_ENTITY secretion|nmod|opener secretion|compound|END_ENTITY	No deterioration of insulin secretion by the potassium channel opener pinacidil in essential hypertension .
263797	0	potassium	19,28	kallikrein	62,72	potassium	kallikrein	MESH:D011188	9622	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|excretion excretion|nmod|END_ENTITY	Effects of dietary potassium and race on urinary excretion of kallikrein and aldosterone in man .
793839	0	potassium	110,119	luteinizing_hormone-releasing_hormone	20,57	potassium	luteinizing hormone-releasing hormone	MESH:D011188	25194(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|release release|nmod|END_ENTITY	In vitro release of luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- from rat mediobasal_hypothalamus : effects of potassium , calcium and dopamine .
7508434	0	potassium	152,161	mSlo	124,128	potassium	mSlo	MESH:D011188	16531(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY family|nmod|channels family|compound|END_ENTITY	Subunit composition of the high conductance calcium-activated potassium channel from smooth muscle , a representative of the mSlo and slowpoke family of potassium channels .
7508434	0	potassium	62,71	mSlo	124,128	potassium	mSlo	MESH:D011188	16531(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY calcium-activated|dobj|channel calcium-activated|nmod|muscle muscle|appos|representative representative|nmod|family family|compound|END_ENTITY	Subunit composition of the high conductance calcium-activated potassium channel from smooth muscle , a representative of the mSlo and slowpoke family of potassium channels .
7687074	0	potassium	61,70	mSlo	0,4	potassium	mSlo	MESH:D011188	16531(Tax:10090)	Chemical	Gene	channels|amod|START_ENTITY encoding|dobj|channels gene|acl|encoding END_ENTITY|appos|gene	mSlo , a complex mouse gene encoding `` maxi '' calcium-activated potassium channels .
8938718	0	potassium	63,72	mSlo	30,34	potassium	mSlo	MESH:D011188	16531(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY modulation|appos|channel modulation|nmod|END_ENTITY	State-dependent modulation of mSlo , a cloned calcium-dependent potassium channel .
9405514	0	potassium	81,90	mSlo	48,52	potassium	mSlo	MESH:D011188	16531(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|appos|channel	Characterization of gating and peptide block of mSlo , a cloned calcium-dependent potassium channel .
11501168	0	potassium	22,31	melittin	10,18	potassium	melittin	MESH:D011188	406130(Tax:7460)	Chemical	Gene	currents|compound|START_ENTITY END_ENTITY|nmod|currents	Effect of melittin on potassium currents and action potential in ventricular myocytes of guinea_pig .
10409658	0	potassium	68,77	minK	122,126	potassium	minK	MESH:D011188	446555(Tax:8355)	Chemical	Gene	channels|compound|START_ENTITY linker|nmod|channels mutations|nmod|linker modify|nsubj|mutations modify|nmod|subunits subunits|compound|END_ENTITY	Long_QT_syndrome-associated mutations in the S4-S5 linker of KvLQT1 potassium channels modify gating and interaction with minK subunits .
11306689	0	potassium	42,51	minK	36,40	potassium	minK	MESH:D011188	50488	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|appos|channels	Cocaine blocks HERG , but not KvLQT1 + minK , potassium channels .
2065015	0	potassium	18,27	minK	38,42	potassium	minK	MESH:D011188	42982(Tax:7227)	Chemical	Gene	channels|compound|START_ENTITY channels|dep|END_ENTITY	Voltage-dependent potassium channels : minK and Shaker families .
7514215	0	potassium	9,18	minK	4,8	potassium	minK	MESH:D011188	398417(Tax:8355)	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	The minK potassium channel exists in functional and nonfunctional forms when expressed in the plasma membrane of Xenopus oocytes .
7605639	0	potassium	28,37	minK	23,27	potassium	minK	MESH:D011188	398417(Tax:8355)	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Subunit composition of minK potassium channels .
7828904	0	potassium	50,59	minK	73,77	potassium	minK	MESH:D011188	3753	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Polymorphism of the gene encoding a human minimal potassium ion channel -LRB- minK -RRB- .
8271270	0	potassium	33,42	minK	28,32	potassium	minK	MESH:D011188	25471(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Inward rectification of the minK potassium channel .
8443177	0	potassium	96,105	minK	91,95	potassium	minK	MESH:D011188	3753	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Spectroscopic and functional characterization of the putative transmembrane segment of the minK potassium channel .
8900282	0	potassium	69,78	minK	18,22	potassium	minK	MESH:D011188	3753	Chemical	Gene	form|dobj|START_ENTITY associate|xcomp|form associate|nsubj|proteins proteins|appos|END_ENTITY	K -LRB- V -RRB- LQT1 and lsK -LRB- minK -RRB- proteins associate to form the I -LRB- Ks -RRB- cardiac potassium current .
9230130	0	potassium	51,60	minK	78,82	potassium	minK	MESH:D011188	3753	Chemical	Gene	protein|compound|START_ENTITY region|nmod|protein region|appos|END_ENTITY	Synthetic putative transmembrane region of minimal potassium channel protein -LRB- minK -RRB- adopts an alpha-helical conformation in phospholipid membranes .
9817805	0	potassium	53,62	minK	104,108	potassium	minK	MESH:D011188	446555(Tax:8355)	Chemical	Gene	channels|compound|START_ENTITY conductance|nmod|channels Increase|nmod|conductance induced|nsubj|Increase induced|nmod|association association|nmod|END_ENTITY	Increase of the single-channel conductance of KvLQT1 potassium channels induced by the association with minK .
8545061	0	potassium	69,78	myosin	11,17	potassium	myosin	MESH:D011188	79784	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|inhibitors inhibitors|amod|END_ENTITY	Effects of myosin light chain kinase inhibitors on delayed rectifier potassium current in bullfrog sympathetic neurons .
17699685	0	potassium	74,83	p62	53,56	potassium	p62	MESH:D011188	18226(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|nmod|channel	Role of protein_kinase_Czeta and its adaptor protein p62 in voltage-gated potassium channel modulation in pulmonary arteries .
167590	0	potassium	50,59	parathyroid_hormone	27,46	potassium	parathyroid hormone	MESH:D011188	24694(Tax:10116)	Chemical	Gene	depletion|compound|START_ENTITY END_ENTITY|nmod|depletion	Impaired renal response to parathyroid_hormone in potassium depletion .
24685970	0	potassium	90,99	parathyroid_hormone-related_peptide	11,46	potassium	parathyroid hormone-related peptide	MESH:D011188	24695(Tax:10116)	Chemical	Gene	channel|amod|START_ENTITY channel|amod|END_ENTITY	Effects of parathyroid_hormone-related_peptide on the large conductance calcium-activated potassium channel and calcium homeostasis in vascular smooth muscle cells .
1899114	0	potassium	93,102	prolactin	19,28	potassium	prolactin	MESH:D011188	24683(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY secretion|acl|induced secretion|compound|END_ENTITY	Quinidine inhibits prolactin secretion induced by thyrotropin-releasing_hormone , high medium potassium or hyposmolarity in GH4C1 cells .
26022182	0	potassium	62,71	r-ERG	56,61	potassium	r-ERG	MESH:D011188	502916(Tax:10116)	Chemical	Gene	currents|compound|START_ENTITY currents|amod|END_ENTITY	ERK and RSK are necessary for TRH-induced inhibition of r-ERG potassium currents in rat pituitary GH3 cells .
11041555	0	potassium	8,17	renin	45,50	potassium	renin	MESH:D011188	24715(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|nmod|control control|nmod|END_ENTITY	Role of potassium channels in the control of renin secretion from isolated perfused rat kidneys .
2544410	0	potassium	94,103	renin	14,19	potassium	renin	MESH:D011188	24715(Tax:10116)	Chemical	Gene	response|acl|START_ENTITY Production|dep|response Production|nmod|END_ENTITY	Production of renin , angiotensin_II , and aldosterone by adrenal explant cultures : response to potassium and converting enzyme inhibition .
3883811	0	potassium	57,66	renin	26,31	potassium	renin	MESH:D011188	24715(Tax:10116)	Chemical	Gene	loading|compound|START_ENTITY Role|nmod|loading Role|nmod|prostaglandins prostaglandins|nmod|suppression suppression|compound|END_ENTITY	Role of prostaglandins in renin suppression during acute potassium loading .
4319970	0	potassium	17,26	renin	81,86	potassium	renin	MESH:D011188	5972	Chemical	Gene	administration|compound|START_ENTITY influence|nmod|administration END_ENTITY|nsubj|influence	The influence of potassium administration and of potassium deprivation on plasma renin in normal and hypertensive subjects .
5431662	0	potassium	19,28	renin	50,55	potassium	renin	MESH:D011188	403838(Tax:9615)	Chemical	Gene	deficiency|compound|START_ENTITY Effects|nmod|deficiency Effects|nmod|activity activity|compound|END_ENTITY	Effects of chronic potassium deficiency on plasma renin activity .
6337502	0	potassium	54,63	renin	19,24	potassium	renin	MESH:D011188	5972	Chemical	Gene	depletion|compound|START_ENTITY Effects|nmod|depletion Effects|nmod|responses responses|compound|END_ENTITY	Effects of NaCl on renin and aldosterone responses to potassium depletion .
6428366	0	potassium	12,21	renin	25,30	potassium	renin	MESH:D011188	5972	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Effects of potassium on renin and aldosterone -RSB- .
6759133	0	potassium	83,92	renin	7,12	potassium	renin	MESH:D011188	5972	Chemical	Gene	intakes|compound|START_ENTITY infants|nmod|intakes concentration|nmod|infants END_ENTITY|dobj|concentration	Plasma renin activity and plasma aldosterone concentration in infants with various potassium intakes .
6991669	0	potassium	59,68	renin	72,77	potassium	renin	MESH:D011188	24715(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Separate and combined effects of ouabain and extracellular potassium on renin secretion from rat renal cortical slices .
7003099	0	potassium	89,98	renin	42,47	potassium	renin	MESH:D011188	24715(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|Effect Effect|nmod|D-600 D-600|nmod|inhibition inhibition|nmod|END_ENTITY	Effect of D-600 on inhibition of in vitro renin release in the rat by high extracellular potassium and angiotensin_II .
7044145	0	potassium	17,26	renin	78,83	potassium	renin	MESH:D011188	24715(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY infusions|nsubj|Effects infusions|nmod|salts salts|nmod|chloride chloride|nmod|activity activity|compound|END_ENTITY	Effects of acute potassium infusions with salts other than chloride on plasma renin activity .
7889179	8	potassium	1251,1260	renin	1086,1091	potassium	renin	MESH:D011188	5972	Chemical	Gene	levels|compound|START_ENTITY response|nmod|levels reappearance|nmod|response normalized|nmod|reappearance normalized|nsubj|activity activity|compound|END_ENTITY	Plasma renin activity and aldosterone plasma levels normalized 1 month later , with reappearance also of a plasma renin activity postural response and maintenance of normal potassium plasma levels even on a high sodium and normal potassium diet .
837868	0	potassium	16,25	renin	44,49	potassium	renin	MESH:D011188	24715(Tax:10116)	Chemical	Gene	loading|compound|START_ENTITY loading|nmod|END_ENTITY	Effect of acute potassium loading on plasma renin and on urinary aldosterone in rats .
23115170	0	potassium	102,111	slack	96,101	potassium	slack	MESH:D011188	57582	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Regulation of neuronal excitability by interaction of fragile_X_mental_retardation_protein with slack potassium channels .
15559785	0	potassium	63,72	snail	89,94	potassium	snail	MESH:D011188	6615	Chemical	Gene	channels|compound|START_ENTITY channels|nmod|END_ENTITY	-LSB- Influence of He-Ne laser irradiation and local anesthetics on potassium channels in the snail neurons -RSB- .
9631439	0	potassium	20,29	snail	51,56	potassium	snail	MESH:D011188	6615	Chemical	Gene	channels|compound|START_ENTITY channels|nmod|neurons neurons|compound|END_ENTITY	Diversity of single potassium channels in isolated snail neurons .
21649805	0	potassium	80,89	sulfonylurea_receptor_1	14,37	potassium	sulfonylurea receptor 1	MESH:D011188	6833	Chemical	Gene	channels|compound|START_ENTITY role|nmod|channels role|nmod|END_ENTITY	A role of the sulfonylurea_receptor_1 in endocytic trafficking of ATP-sensitive potassium channels .
10670456	0	potassium	79,88	traak	73,78	potassium	traak	MESH:D011188	16528(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|dobj|channel	Immunolocalization of the arachidonic_acid and mechanosensitive baseline traak potassium channel in the nervous system .
26603619	0	potassium	52,61	transglutaminase_2	15,33	potassium	transglutaminase 2	MESH:D011188	56083(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Involvement of transglutaminase_2 and voltage-gated potassium channels in cystamine vasodilatation in rat mesenteric small arteries .
12535075	0	potassium	20,29	trk1	109,113	potassium	TRK2	MESH:D011188	853924(Tax:4932)	Chemical	Gene	transport|compound|START_ENTITY Characterization|nmod|transport Characterization|acl|carrying carrying|dobj|combinations combinations|nmod|mutations mutations|amod|END_ENTITY	Characterization of potassium transport in wild-type and isogenic yeast strains carrying all combinations of trk1 , trk2 and tok1 null mutations .
25777080	0	potassium	131,140	trk1	88,92	potassium	trk1	MESH:D011188	853312(Tax:4932)	Chemical	Gene	limiting|dobj|START_ENTITY grown|advcl|limiting grown|nsubj|characterization characterization|nmod|mutants mutants|amod|END_ENTITY	A physiological , biochemical and proteomic characterization of Saccharomyces_cerevisiae trk1 ,2 transport mutants grown at limiting potassium .
9614085	0	potassium	8,17	trk1	28,32	potassium	trk1	MESH:D011188	853312(Tax:4932)	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|mutants mutants|amod|END_ENTITY	Ectopic potassium uptake in trk1 trk2 mutants of Saccharomyces_cerevisiae correlates with a highly hyperpolarized membrane potential .
9614085	0	potassium	8,17	trk2	33,37	potassium	trk2	MESH:D011188	853924(Tax:4932)	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|mutants mutants|amod|END_ENTITY	Ectopic potassium uptake in trk1 trk2 mutants of Saccharomyces_cerevisiae correlates with a highly hyperpolarized membrane potential .
8244534	0	potassium	43,52	tumor_necrosis_factor	11,32	potassium	tumor necrosis factor	MESH:D011188	7124	Chemical	Gene	current|compound|START_ENTITY Effects|nmod|current Effects|nmod|END_ENTITY	Effects of tumor_necrosis_factor on inward potassium current and cell morphology in cultured human oligodendrocytes .
2876755	0	potassium	107,116	tyrosine_hydroxylase	29,49	potassium	tyrosine hydroxylase	MESH:D011188	7054	Chemical	Gene	effects|nmod|START_ENTITY Expression|dep|effects Expression|nmod|END_ENTITY	Expression and regulation of tyrosine_hydroxylase in adult sensory neurons in culture : effects of elevated potassium and nerve growth factor .
8595887	0	potassium	87,96	uKATP-1	106,113	potassium	uKATP-1	MESH:D011188	3764	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	cDNA sequence , gene structure , and chromosomal localization of the human ATP-sensitive potassium channel , uKATP-1 , gene -LRB- KCNJ8 -RRB- .
14678080	0	potassium	39,48	urinary_trypsin_inhibitor	10,35	potassium	urinary trypsin inhibitor	MESH:D011188	259	Chemical	Gene	currents|compound|START_ENTITY END_ENTITY|nmod|currents	Effect of urinary_trypsin_inhibitor on potassium currents : fetus modulates membrane excitability by production of UTI .
17218966	0	potassium	25,34	uroguanylin	10,21	potassium	uroguanylin	MESH:D011188	64055(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY Effect|nmod|transport Effect|nmod|END_ENTITY	Effect of uroguanylin on potassium and bicarbonate transport in rat renal tubules .
23678030	0	potassium	38,47	vasopressin	8,19	potassium	vasopressin	MESH:D011188	396995(Tax:9823)	Chemical	Gene	maintenance|nmod|START_ENTITY END_ENTITY|nmod|maintenance	Role of vasopressin in maintenance of potassium homeostasis in severe hemorrhage .
15733107	0	potassium-magnesium_citrate	11,38	ATP_citrate_lyase	68,85	potassium-magnesium citrate	ATP citrate lyase	MESH:C066902	47	Chemical	Gene	supplementation|amod|START_ENTITY supplementation|nmod|END_ENTITY	Effects of potassium-magnesium_citrate supplementation on cytosolic ATP_citrate_lyase and mitochondrial_aconitase activity in leukocytes : a window on renal citrate metabolism .
17456300	0	potassium_EDTA	14,28	parathyroid_hormone	49,68	potassium EDTA	parathyroid hormone	MESH:D004492	5741	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|stability stability|nmod|END_ENTITY	The effect of potassium_EDTA on the stability of parathyroid_hormone in whole blood .
24684235	0	potassium_acyltrifluoroborate	59,88	KAT	90,93	potassium acyltrifluoroborate	KAT	null	100131187	Chemical	Gene	formation|amod|START_ENTITY formation|appos|END_ENTITY	Rapid ligations with equimolar reactants in water with the potassium_acyltrifluoroborate -LRB- KAT -RRB- amide formation .
886216	0	potassium_chloride	11,29	renin	40,45	potassium chloride	renin	MESH:D011189	5972	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|compound|END_ENTITY	Effects of potassium_chloride on plasma renin activity during sodium restriction in normal man .
3655875	0	potassium_modulate	43,61	CA1	94,97	potassium modulate	CA1	null	310218(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|region region|compound|END_ENTITY	Activity-evoked increases in extracellular potassium_modulate presynaptic excitability in the CA1 region of the hippocampus .
22245121	0	potassium_perfluorooctanesulfonate	98,132	PPARa	199,204	potassium perfluorooctanesulfonate	PPARa	null	25747(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Hepatocellular hypertrophy and cell proliferation in Sprague-Dawley_rats from dietary exposure to potassium_perfluorooctanesulfonate results from increased expression of xenosensor nuclear receptors PPARa and CAR/PXR .
10746944	0	potassium_permanganate	23,45	metallothionein	72,87	potassium permanganate	metallothionein	MESH:D011196	100304478(Tax:7998)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|mRNA mRNA|compound|END_ENTITY	Effects of the oxidant potassium_permanganate on the expression of gill metallothionein mRNA and its relationship to sublethal whole animal endpoints in channel_catfish .
11697473	0	potassium_peroxodisulfate	48,73	interleukin-2	31,44	potassium peroxodisulfate	interleukin-2	MESH:C009007	3558	Chemical	Gene	Oxidation|nmod|START_ENTITY Oxidation|nmod|END_ENTITY	Oxidation of recombinant human interleukin-2 by potassium_peroxodisulfate .
4139577	0	practolol	70,79	growth-hormone	40,54	practolol	growth-hormone	MESH:D011217	2688	Chemical	Gene	stimulation|nmod|START_ENTITY stimulation|amod|END_ENTITY	Letter : Enhancement of levodopa-induced growth-hormone stimulation by practolol .
16940083	0	pradefovir	24,34	CYP3A4	38,44	pradefovir	CYP3A4	MESH:C497721	1576	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Metabolic activation of pradefovir by CYP3A4 and its potential as an inhibitor or inducer .
25889044	0	pradigastat	30,41	DGAT1	14,19	pradigastat	DGAT1	null	8694	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|inhibitor inhibitor|compound|END_ENTITY	Effect of the DGAT1 inhibitor pradigastat on triglyceride and apoB48 levels in patients with familial_chylomicronemia_syndrome .
25889044	0	pradigastat	30,41	DGAT1	14,19	pradigastat	DGAT1	null	8694	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|inhibitor inhibitor|compound|END_ENTITY	Effect of the DGAT1 inhibitor pradigastat on triglyceride and apoB48 levels in patients with familial_chylomicronemia_syndrome .
23888707	0	praeruptorin_A	35,49	UGT1A1	14,20	praeruptorin A	UGT1A1	MESH:C441070	54658	Chemical	Gene	expression|nmod|START_ENTITY expression|nsubj|Induction Induction|nmod|END_ENTITY	-LSB- Induction of UGT1A1 expression by praeruptorin_A and praeruptorin_C through hCAR pathway -RSB- .
19549514	0	pramipexole	26,37	dopamine_D3_receptor	91,111	pramipexole	dopamine D3 receptor	MESH:C061333	29238(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|agonist agonist|amod|END_ENTITY	Antidepressant effects of pramipexole , a dopamine D3/D2 receptor agonist , and 7-OH-DPAT , a dopamine_D3_receptor agonist , in olfactory bulbectomized rats .
9212325	0	pramlintide	41,52	amylin	11,17	pramlintide	amylin	MESH:C105254	3375	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of amylin and the amylin agonist pramlintide on glucose metabolism .
9389419	0	pramlintide	38,49	amylin	59,65	pramlintide	amylin	MESH:C105254	3375	Chemical	Gene	START_ENTITY|appos|analogue analogue|compound|END_ENTITY	Effects of 4 weeks ' administration of pramlintide , a human amylin analogue , on glycaemia control in patients with IDDM : effects on plasma glucose profiles and serum fructosamine concentrations .
18236018	0	pranlukast	21,31	cysteinyl-leukotriene_receptor_1	35,67	pranlukast	cysteinyl-leukotriene receptor 1	MESH:C047681	114099(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Protective effect of pranlukast , a cysteinyl-leukotriene_receptor_1 antagonist , on indomethacin-induced small intestinal damage in rats .
11527250	0	pranlukast	11,21	cysteinyl_leukotriene_receptor_1	25,57	pranlukast	cysteinyl leukotriene receptor 1	MESH:C047681	10800	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|antagonist antagonist|amod|END_ENTITY	Effects of pranlukast , a cysteinyl_leukotriene_receptor_1 antagonist , combined with inhaled beclomethasone in patients with moderate or severe asthma .
10028377	0	pranlukast_hydrate	11,29	eosinophil_cationic_protein	39,66	pranlukast hydrate	eosinophil cationic protein	null	6037	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|compound|END_ENTITY	Effects of pranlukast_hydrate on serum eosinophil_cationic_protein levels in patients with adult bronchial_asthma .
15852222	0	prasugrel	24,33	P2Y12	94,99	prasugrel	P2Y12	MESH:C408153	64803(Tax:10116)	Chemical	Gene	CS-747|appos|START_ENTITY Pharmacology|nmod|CS-747 Pharmacology|appos|agent agent|nmod|activity activity|nummod|END_ENTITY	Pharmacology of CS-747 -LRB- prasugrel , LY640315 -RRB- , a novel , potent antiplatelet agent with in vivo P2Y12 receptor antagonist activity .
15967851	0	prasugrel	25,34	P2Y12	78,83	prasugrel	P2Y12	MESH:C408153	64805	Chemical	Gene	comparison|nmod|START_ENTITY comparison|appos|antagonist antagonist|compound|END_ENTITY	Randomized comparison of prasugrel -LRB- CS-747 , LY640315 -RRB- , a novel thienopyridine P2Y12 antagonist , with clopidogrel in percutaneous coronary intervention : results of the Joint Utilization of Medications to Block Platelets Optimally -LRB- JUMBO -RRB- - TIMI 26 trial .
16268477	0	prasugrel	103,112	P2Y12	133,138	prasugrel	P2Y12	MESH:C408153	64805	Chemical	Gene	CS-747|appos|START_ENTITY metabolite|nmod|CS-747 inhibition|appos|metabolite inhibition|appos|inhibitor inhibitor|compound|END_ENTITY	Stereoselective inhibition of human platelet_aggregation by R-138727 , the active metabolite of CS-747 -LRB- prasugrel , LY640315 -RRB- , a novel P2Y12 receptor inhibitor .
16769598	0	prasugrel	53,62	P2Y12	95,100	prasugrel	P2Y12	MESH:C408153	64805	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY pharmacokinetics|dep|inhibitor inhibitor|compound|END_ENTITY	Platelet inhibitory activity and pharmacokinetics of prasugrel -LRB- CS-747 -RRB- a novel thienopyridine P2Y12 inhibitor : a single ascending dose study in healthy humans .
16769599	0	prasugrel	53,62	P2Y12	95,100	prasugrel	P2Y12	MESH:C408153	64805	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY pharmacokinetics|dep|inhibitor inhibitor|compound|END_ENTITY	Platelet inhibitory activity and pharmacokinetics of prasugrel -LRB- CS-747 -RRB- a novel thienopyridine P2Y12 inhibitor : a multiple-dose study in healthy humans .
17076696	0	prasugrel	25,34	P2Y12	68,73	prasugrel	P2Y12	MESH:C408153	64805	Chemical	Gene	study|nmod|START_ENTITY study|appos|inhibitor inhibitor|compound|END_ENTITY	A multiple dose study of prasugrel -LRB- CS-747 -RRB- , a novel thienopyridine P2Y12 inhibitor , compared with clopidogrel in healthy humans .
17681285	0	prasugrel	167,176	P2Y12	148,153	prasugrel	P2Y12	MESH:C408153	70839(Tax:10090)	Chemical	Gene	receptors|nmod|START_ENTITY receptors|nummod|END_ENTITY	The influence of P2Y12 receptor deficiency on the platelet inhibitory activities of prasugrel in a mouse model : evidence for specific inhibition of P2Y12 receptors by prasugrel .
17681285	0	prasugrel	167,176	P2Y12	17,22	prasugrel	P2Y12	MESH:C408153	70839(Tax:10090)	Chemical	Gene	receptors|nmod|START_ENTITY inhibition|nmod|receptors evidence|nmod|inhibition influence|dep|evidence influence|nmod|deficiency deficiency|compound|END_ENTITY	The influence of P2Y12 receptor deficiency on the platelet inhibitory activities of prasugrel in a mouse model : evidence for specific inhibition of P2Y12 receptors by prasugrel .
17681285	0	prasugrel	84,93	P2Y12	148,153	prasugrel	P2Y12	MESH:C408153	70839(Tax:10090)	Chemical	Gene	activities|nmod|START_ENTITY deficiency|nmod|activities influence|nmod|deficiency influence|dep|evidence evidence|nmod|inhibition inhibition|nmod|receptors receptors|nummod|END_ENTITY	The influence of P2Y12 receptor deficiency on the platelet inhibitory activities of prasugrel in a mouse model : evidence for specific inhibition of P2Y12 receptors by prasugrel .
17681285	0	prasugrel	84,93	P2Y12	17,22	prasugrel	P2Y12	MESH:C408153	70839(Tax:10090)	Chemical	Gene	activities|nmod|START_ENTITY deficiency|nmod|activities deficiency|compound|END_ENTITY	The influence of P2Y12 receptor deficiency on the platelet inhibitory activities of prasugrel in a mouse model : evidence for specific inhibition of P2Y12 receptors by prasugrel .
18278193	0	prasugrel	133,142	P2Y12	25,30	prasugrel	P2Y12	MESH:C408153	64805	Chemical	Gene	administration|amod|START_ENTITY levels|nmod|administration range|nmod|levels monitor|nmod|range use|acl|monitor use|nmod|device device|compound|END_ENTITY	The use of the VerifyNow P2Y12 point-of-care device to monitor platelet function across a range of P2Y12 inhibition levels following prasugrel and clopidogrel administration .
18278193	0	prasugrel	133,142	P2Y12	99,104	prasugrel	P2Y12	MESH:C408153	64805	Chemical	Gene	administration|amod|START_ENTITY levels|nmod|administration levels|nummod|END_ENTITY	The use of the VerifyNow P2Y12 point-of-care device to monitor platelet function across a range of P2Y12 inhibition levels following prasugrel and clopidogrel administration .
19050170	0	prasugrel	53,62	P2Y12	0,5	prasugrel	P2Y12	MESH:C408153	64805	Chemical	Gene	focus|nmod|START_ENTITY inhibitors|dep|focus inhibitors|nummod|END_ENTITY	P2Y12 inhibitors in cardiovascular_disease : focus on prasugrel .
19249429	0	prasugrel	104,113	P2Y12	73,78	prasugrel	P2Y12	MESH:C408153	64805	Chemical	Gene	treated|nmod|START_ENTITY patients|acl|treated inhibition|nmod|patients inhibition|nmod|END_ENTITY	Assessment of P2Y -LRB- 12 -RRB- inhibition with the point-of-care device VerifyNow P2Y12 in patients treated with prasugrel or clopidogrel coadministered with aspirin .
20386460	0	prasugrel	127,136	P2Y12	30,35	prasugrel	P2Y12	MESH:C408153	64805	Chemical	Gene	monitor|nmod|START_ENTITY aggregometry|xcomp|monitor aggregometry|nsubj|comparison comparison|nmod|device device|compound|END_ENTITY	A comparison of the VerifyNow P2Y12 point-of-care device and light transmission aggregometry to monitor platelet function with prasugrel and clopidogrel : an integrated analysis .
21697729	0	prasugrel	41,50	P2Y12	22,27	prasugrel	P2Y12	MESH:C408153	64803(Tax:10116)	Chemical	Gene	receptors|nmod|START_ENTITY receptors|nummod|END_ENTITY	Selective blockade of P2Y12 receptors by prasugrel inhibits myocardial_infarction induced by thrombotic_coronary_artery_occlusion in rats .
21713327	0	prasugrel	133,142	P2Y12	115,120	prasugrel	P2Y12	MESH:C408153	64805	Chemical	Gene	clopidogrel|amod|START_ENTITY blockade|nmod|clopidogrel blockade|compound|END_ENTITY	Intrinsic platelet reactivity before P2Y12 blockade contributes to residual platelet reactivity despite high-level P2Y12 blockade by prasugrel or high-dose clopidogrel .
21713327	0	prasugrel	133,142	P2Y12	37,42	prasugrel	P2Y12	MESH:C408153	64805	Chemical	Gene	clopidogrel|amod|START_ENTITY blockade|nmod|clopidogrel contributes|nmod|blockade contributes|nsubj|reactivity reactivity|nmod|blockade blockade|compound|END_ENTITY	Intrinsic platelet reactivity before P2Y12 blockade contributes to residual platelet reactivity despite high-level P2Y12 blockade by prasugrel or high-dose clopidogrel .
23106905	0	prasugrel	65,74	P2Y12	149,154	prasugrel	P2Y12	MESH:C408153	64805	Chemical	Gene	aspirin|appos|START_ENTITY therapy|dep|aspirin comparison|nmod|therapy comparison|acl|using using|dobj|assay assay|nummod|END_ENTITY	Randomized comparison of new dual-antiplatelet therapy -LRB- aspirin , prasugrel -RRB- and triple-antiplatelet therapy -LRB- aspirin , clopidogrel , cilostazol -RRB- using P2Y12 point-of-care assay in patients with STEMI undergoing primary PCI .
24486281	0	prasugrel	131,140	P2Y12	11,16	prasugrel	P2Y12	MESH:C408153	64805	Chemical	Gene	clopidogrel|amod|START_ENTITY impact|nmod|clopidogrel inhibition|dep|impact inhibition|compound|END_ENTITY	Optimizing P2Y12 receptor inhibition in patients with acute_coronary_syndrome on the basis of platelet function testing : impact of prasugrel and high-dose clopidogrel .
25130912	6	prasugrel	762,771	P2Y12	789,794	prasugrel	P2Y12	MESH:C408153	70839(Tax:10090)	Chemical	Gene	administration|nmod|START_ENTITY administration|appos|antagonist antagonist|compound|END_ENTITY	The administration of prasugrel , a thienopiridyl P2Y12 antagonist , did not affect the activation state of circulating platelets suggesting P2Y12 independent mechanism of activation .
26340851	0	prasugrel	43,52	P2Y12	25,30	prasugrel	P2Y12	MESH:C408153	64805	Chemical	Gene	clopidogrel|compound|START_ENTITY inhibitors|appos|clopidogrel inhibitors|nummod|END_ENTITY	Antiplatelet efficacy of P2Y12 inhibitors -LRB- prasugrel , ticagrelor , clopidogrel -RRB- in patients treated with mild therapeutic_hypothermia after cardiac_arrest due to acute myocardial_infarction .
18372401	0	prasugrel	25,34	carboxylesterases_1_and_2	79,104	prasugrel	carboxylesterases 1 and 2	MESH:C408153	1066;8824	Chemical	Gene	biotransformation|nmod|START_ENTITY biotransformation|nmod|END_ENTITY	The biotransformation of prasugrel , a new thienopyridine prodrug , by the human carboxylesterases_1_and_2 .
18360048	0	pratosartan	67,78	angiotensin_II_type_1_receptor	27,57	pratosartan	angiotensin II type 1 receptor	MESH:C528642	185	Chemical	Gene	blocker|appos|START_ENTITY blocker|amod|END_ENTITY	Clinical efficacy of a new angiotensin_II_type_1_receptor blocker , pratosartan , in hypertensive patients .
15242490	0	pravastatin	11,22	Abcg5	92,97	pravastatin	Abcg5	MESH:D017035	114628(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|excretion excretion|nmod|END_ENTITY	Effects of pravastatin and bezafibrate on biliary lipid excretion and hepatic expression of Abcg5 and Abcg8 in the rat .
8344125	0	pravastatin	54,65	Apolipoprotein_E	0,16	pravastatin	Apolipoprotein E	MESH:D017035	348	Chemical	Gene	response|acl|START_ENTITY affects|dobj|response affects|nsubj|polymorphism polymorphism|compound|END_ENTITY	Apolipoprotein_E polymorphism affects the response to pravastatin on plasma apolipoproteins in diabetic patients .
18985798	5	pravastatin	875,886	Bsep	901,905	pravastatin	Bsep	MESH:D017035	83569(Tax:10116)	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|dobj|END_ENTITY	The uptake of -LSB- -LRB- 3 -RRB- H -RSB- taurocholic_acid by all three transporters was significantly inhibited by troglitazone , glibenclamide , and other several inhibitors , while pravastatin inhibited dog Bsep and human BSEP , but not rat Bsep at 100 microM .
10411845	0	pravastatin	21,32	C-reactive_protein	60,78	pravastatin	C-reactive protein	MESH:D017035	1401	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Long-term effects of pravastatin on plasma concentration of C-reactive_protein .
11434828	0	pravastatin	59,70	C-reactive_protein	28,46	pravastatin	C-reactive protein	MESH:D017035	1401	Chemical	Gene	evaluation|amod|START_ENTITY Effect|dep|evaluation Effect|nmod|therapy therapy|nmod|levels levels|amod|END_ENTITY	Effect of statin therapy on C-reactive_protein levels : the pravastatin inflammation/CRP evaluation -LRB- PRINCE -RRB- : a randomized trial and cohort study .
15469788	0	pravastatin	39,50	C-reactive_protein	54,72	pravastatin	C-reactive protein	MESH:D017035	1401	Chemical	Gene	administration|nmod|START_ENTITY Effect|nmod|administration Effect|nmod|levels levels|amod|END_ENTITY	-LSB- Effect of the early administration of pravastatin on C-reactive_protein and interleukin-6 levels in the acute phase of myocardial_infarction with ST segment elevation -RSB- .
15801991	0	pravastatin	21,32	C-reactive_protein	52,70	pravastatin	C-reactive protein	MESH:D017035	1401	Chemical	Gene	switching|dobj|START_ENTITY switching|advcl|cerivastatin cerivastatin|nmod|END_ENTITY	Effects of switching pravastatin to cerivastatin on C-reactive_protein , butyrylcholinesterase , and lipids .
16444450	0	pravastatin	53,64	C-reactive_protein	21,39	pravastatin	C-reactive protein	MESH:D017035	1401	Chemical	Gene	course|nmod|START_ENTITY course|nmod|reduction reduction|amod|END_ENTITY	Time course of rapid C-reactive_protein reduction by pravastatin in patients with stable_angina .
17996517	0	pravastatin	24,35	C-reactive_protein	47,65	pravastatin	C-reactive protein	MESH:D017035	1401	Chemical	Gene	therapy|compound|START_ENTITY Effect|nmod|therapy Effect|nmod|cholesterol cholesterol|compound|END_ENTITY	Effect of withdrawal of pravastatin therapy on C-reactive_protein and low-density lipoprotein cholesterol .
18312772	0	pravastatin	142,153	C-reactive_protein	14,32	pravastatin	C-reactive protein	MESH:D017035	1401	Chemical	Gene	patients|nmod|START_ENTITY outcomes|nmod|patients predictors|nmod|outcomes Usefulness|nmod|predictors Usefulness|nmod|END_ENTITY	Usefulness of C-reactive_protein and interleukin-6 as predictors of outcomes in patients with chronic_obstructive_pulmonary_disease receiving pravastatin .
2123791	0	pravastatin	56,67	HMG-CoA-reductase	28,45	pravastatin	HMG-CoA-reductase	MESH:D017035	3156	Chemical	Gene	START_ENTITY|nsubj|efficacy efficacy|nmod|inhibitor inhibitor|amod|END_ENTITY	Therapeutic efficacy of the HMG-CoA-reductase inhibitor pravastatin in hyperlipoproteinaemia type II .
1902546	0	pravastatin	11,22	HMG-CoA_reductase	30,47	pravastatin	HMG-CoA reductase	MESH:D017035	3156	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effects of pravastatin , a new HMG-CoA_reductase inhibitor , on vitamin_D synthesis in man .
1910254	0	pravastatin	40,51	HMG-CoA_reductase	59,76	pravastatin	HMG-CoA reductase	MESH:D017035	3156	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Lipid-lowering diets in patients taking pravastatin , a new HMG-CoA_reductase inhibitor : compliance and adequacy .
24948077	0	pravastatin	29,40	HMG-CoA_reductase	0,17	pravastatin	HMG-CoA reductase	MESH:D017035	15357(Tax:10090)	Chemical	Gene	suppress|compound|START_ENTITY suppress|amod|END_ENTITY	HMG-CoA_reductase inhibitors pravastatin , lovastatin and simvastatin suppress delayed rectifier K -LRB- + -RRB- - channel currents in murine thymocytes .
7730737	0	pravastatin	35,46	HMG-Co_A_reductase	70,88	pravastatin	HMG-Co A reductase	MESH:D017035	3156	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|inhibitor inhibitor|nmod|END_ENTITY	Efficacy and short-term effects of pravastatin , a potent inhibitor of HMG-Co_A_reductase , on hypercholesterolemia in climacteric women .
12888915	0	pravastatin	76,87	IL-6	0,4	pravastatin	IL-6	MESH:D017035	3569	Chemical	Gene	induced|nmod|START_ENTITY cells|acl|induced inhibition|nmod|cells factor|nmod|inhibition factor|nsubj|END_ENTITY	IL-6 is a key factor in growth inhibition of human myeloma cells induced by pravastatin , an HMG-CoA reductase inhibitor .
26826613	0	pravastatin	98,109	IL-6	58,62	pravastatin	IL-6	MESH:D017035	3569	Chemical	Gene	treatment|compound|START_ENTITY patients|nmod|treatment patients|dep|polymorphisms polymorphisms|nmod|levels levels|compound|END_ENTITY	Effects of the SLCO1B1 * 1 and SLCO1B1 * 5 polymorphisms on IL-6 and IL-10 levels in patients under pravastatin treatment prior to inguinal_hernia_repair .
16286607	0	pravastatin	58,69	Low-density_lipoprotein_receptor	0,32	pravastatin	Low-density lipoprotein receptor	MESH:D017035	3949	Chemical	Gene	genotype|nmod|START_ENTITY genotype|compound|END_ENTITY	Low-density_lipoprotein_receptor genotype and response to pravastatin in children with familial_hypercholesterolemia : substudy of an intima-media_thickness trial .
17523051	0	pravastatin	62,73	OATP1B1	86,93	pravastatin	OATP1B1	MESH:D017035	10599	Chemical	Gene	START_ENTITY|acl|mediated mediated|nmod|END_ENTITY	Gemfibrozil and its glucuronide inhibit the hepatic uptake of pravastatin mediated by OATP1B1 .
16368469	0	pravastatin	25,36	P-selectin	68,78	pravastatin	P-selectin	MESH:D017035	6403	Chemical	Gene	effects|nmod|START_ENTITY Comparison|nmod|effects Comparison|nmod|END_ENTITY	Comparison of effects of pravastatin and hormone_therapy on soluble P-selectin and platelet P-selectin expression in postmenopausal_hypercholesterolemic women .
11479481	0	pravastatin	14,25	Q10	55,58	pravastatin	Q10	MESH:D017035	27161	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of pravastatin and atorvastatin on coenzyme Q10 .
17031758	0	pravastatin	11,22	S6_kinase	125,134	pravastatin	S6 kinase	MESH:D017035	83840(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|dep|role role|nmod|END_ENTITY	Effects of pravastatin on ventricular remodeling by activation of myocardial KATP channels in infarcted rats : role of 70-kDa S6_kinase .
26239079	0	pravastatin	82,93	SLC22A9	65,72	pravastatin	SLC22A9	MESH:D017035	114571	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|appos|transporter	Variability in hepatic expression of organic_anion_transporter_7 / SLC22A9 , a novel pravastatin uptake transporter : impact of genetic and regulatory factors .
15932706	0	pravastatin	12,23	TNF-alpha	72,81	pravastatin	TNF-alpha	MESH:D017035	24835(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	-LSB- Effects of pravastatin , fosinopril and their combination on myocardium TNF-alpha expression and ventricular remodeling after myocardial_infarction in rats -RSB- .
11472741	0	pravastatin	85,96	TNF_alpha	18,27	pravastatin	TNF alpha	MESH:D017035	7124	Chemical	Gene	levels|nmod|START_ENTITY levels|nmod|END_ENTITY	Reduced levels of TNF_alpha in hypercholesterolemic individuals after treatment with pravastatin for 8 weeks .
18164019	0	pravastatin	112,123	adiponectin	10,21	pravastatin	adiponectin	MESH:D017035	9370	Chemical	Gene	treated|nmod|START_ENTITY synthesis|acl|treated synthesis|compound|END_ENTITY	Increased adiponectin synthesis in the visceral adipose tissue in men with coronary_artery_disease treated with pravastatin : a role of the attenuation of oxidative stress .
19856791	0	pravastatin	34,45	adiponectin	55,66	pravastatin	adiponectin	MESH:D017035	9370	Chemical	Gene	dose|nmod|START_ENTITY increasing|dobj|dose increasing|nmod|level level|compound|END_ENTITY	Effects of increasing the dose of pravastatin on serum adiponectin level in Japanese mild hypercholesterolemic and hypertensive patients .
20608995	0	pravastatin	11,22	adiponectin	61,72	pravastatin	adiponectin	MESH:D017035	9370	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|generation generation|nmod|END_ENTITY	Effects of pravastatin and rosuvastatin on the generation of adiponectin in the visceral adipose tissue in patients with coronary_artery_disease .
23466100	0	pravastatin	11,22	adiponectin	32,43	pravastatin	adiponectin	MESH:D017035	9370	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|compound|END_ENTITY	Effects of pravastatin on serum adiponectin levels in female patients with type_2_diabetes_mellitus .
7596034	0	pravastatin	20,31	apolipoprotein_A-I	73,91	pravastatin	apolipoprotein A-I	MESH:D017035	100009253(Tax:9986)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Combined effects of pravastatin and probucol on high-density lipoprotein apolipoprotein_A-I kinetics in cholesterol-fed rabbits .
15842977	0	pravastatin	97,108	cholesteryl_ester_transfer_protein	31,65	pravastatin	cholesteryl ester transfer protein	MESH:D017035	1071	Chemical	Gene	Effectiveness|nmod|START_ENTITY Effectiveness|nmod|END_ENTITY	Effectiveness of inhibition of cholesteryl_ester_transfer_protein by JTT-705 in combination with pravastatin in type_II_dyslipidemia .
20466804	0	pravastatin	10,21	connexin43	76,86	pravastatin	connexin43	MESH:D017035	24392(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|role role|nmod|END_ENTITY	Effect of pravastatin on ventricular_arrhythmias in infarcted rats : role of connexin43 .
19099934	0	pravastatin	12,23	connexin_43	38,49	pravastatin	connexin 43	MESH:D017035	14609(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expressions expressions|amod|END_ENTITY	-LSB- Effects of pravastatin on myocardial connexin_43 , IFN-gamma and IL-10 expressions in a murine model of viral_myocarditis induced by Coxsackievirus B3 -RSB- .
11334580	0	pravastatin	69,80	fibrinogen	18,28	pravastatin	fibrinogen	MESH:D017035	2244	Chemical	Gene	-RSB-|compound|START_ENTITY Effect|nmod|-RSB- Effect|nmod|END_ENTITY	-LSB- Effect on plasma fibrinogen of hypercholesterolaemia treatment with pravastatin -RSB- .
7797599	0	pravastatin	11,22	hydroxymethylglutaryl-CoA_reductase	26,61	pravastatin	hydroxymethylglutaryl-CoA reductase	MESH:D017035	3156	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effects of pravastatin , a hydroxymethylglutaryl-CoA_reductase inhibitor , on two human tumour cell lines .
10422491	0	pravastatin	96,107	leptin	7,13	pravastatin	leptin	MESH:D017035	3952	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|dep|effect	-LSB- Serum leptin , early atherosclerosis and hypolipidemia -LRB- a new , previously undescribed effect of pravastatin , a hypolipemic agent -RRB- -RSB- .
8366183	0	pravastatin	38,49	lipoprotein_a	86,99	pravastatin	lipoprotein a	MESH:D017035	4018	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of one year of treatment with pravastatin , an HMG-CoA reductase inhibitor , on lipoprotein_a .
2118022	0	pravastatin	14,25	low_density_lipoprotein_receptor	41,73	pravastatin	low density lipoprotein receptor	MESH:D017035	3949	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|compound|END_ENTITY	The effect of pravastatin in relation to low_density_lipoprotein_receptor activity .
19147525	0	pravastatin	11,22	osteoprotegerin	32,47	pravastatin	osteoprotegerin	MESH:D017035	4982	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|compound|END_ENTITY	Effects of pravastatin on serum osteoprotegerin levels in patients with hypercholesterolemia and type 2 diabetes .
2116173	0	pravastatin_sodium	64,82	3-hydroxy-3-methylglutaryl_coenzyme_A_reductase	86,133	pravastatin sodium	3-hydroxy-3-methylglutaryl coenzyme A reductase	MESH:D017035	15357(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Tissue-selective inhibition of cholesterol synthesis in vivo by pravastatin_sodium , a 3-hydroxy-3-methylglutaryl_coenzyme_A_reductase inhibitor .
10329788	0	pravastatin_sodium	139,157	HMG-CoA_reductase	191,208	pravastatin sodium	HMG-CoA reductase	MESH:D017035	3156	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Crystallization and preliminary X-ray diffraction analysis of cytochrome P450sca-2 from Streptomyces carbophilus involved in production of pravastatin_sodium , a tissue-selective inhibitor of HMG-CoA_reductase .
2106337	0	pravastatin_sodium	15,33	HMG-CoA_reductase	54,71	pravastatin sodium	HMG-CoA reductase	MESH:D017035	3156	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Disposition of pravastatin_sodium , a tissue-selective HMG-CoA_reductase inhibitor , in healthy subjects .
8769685	0	pravastatin_sodium	11,29	fibrinogen	56,66	pravastatin sodium	fibrinogen	MESH:D017035	2244	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|level level|compound|END_ENTITY	Effects of pravastatin_sodium and simvastatin on plasma fibrinogen level and blood rheology in type_II_hyperlipoproteinemia .
1903605	0	praziquantel	71,83	CAA	131,134	praziquantel	CAA	MESH:D011223	10194	Chemical	Gene	_|amod|START_ENTITY _|appos|END_ENTITY	Assessment of cure in schistosomiasis patients after chemotherapy with praziquantel by quantitation of circulating_anodic_antigen _ -LRB- CAA -RRB- in urine .
19852800	0	praziquantel	39,51	CCL3	29,33	praziquantel	CCL3	MESH:D011223	6348	Chemical	Gene	treatment|amod|START_ENTITY END_ENTITY|nmod|treatment	Downregulation of MIP-1alpha / CCL3 with praziquantel treatment in Schistosoma_haematobium and HIV-1_co-infected individuals in a rural community in Zimbabwe .
17357589	0	praziquantel	21,33	cytochrome_p450_3A4	43,62	praziquantel	cytochrome p450 3A4	MESH:D011223	1576	Chemical	Gene	Biotransformation|nmod|START_ENTITY Biotransformation|nmod|END_ENTITY	Biotransformation of praziquantel by human cytochrome_p450_3A4 -LRB- CYP_3A4 -RRB- .
2149548	0	prazosin	93,101	Beta-thromboglobulin	0,20	prazosin	Beta-thromboglobulin	MESH:D011224	5473	Chemical	Gene	therapy|compound|START_ENTITY END_ENTITY|nmod|therapy	Beta-thromboglobulin and platelet_aggregation in essential hypertension and the influence of prazosin therapy .
1353386	0	prazosin	44,52	alpha-1	15,22	prazosin	alpha-1	MESH:D011224	146	Chemical	Gene	START_ENTITY|nsubj|study study|nmod|blocker blocker|amod|END_ENTITY	A study of the alpha-1 adrenoceptor blocker prazosin in the prophylactic management of autonomic_dysreflexia in high spinal_cord_injury patients .
18945226	0	prazosin	52,60	alpha-1	21,28	prazosin	alpha-1	MESH:D011224	146	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	A pilot trial of the alpha-1 adrenergic antagonist , prazosin , for alcohol_dependence .
6146242	0	prazosin	62,70	alpha-1	75,82	prazosin	alpha-1	MESH:D011224	146	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Effects of methoxamine , and alpha-1 adrenoceptor agonist , and prazosin , an alpha-1 antagonist , on the stages of the sleep-waking cycle in the cat .
2408807	0	prazosin	11,19	beta-thromboglobulin	55,75	prazosin	beta-thromboglobulin	MESH:D011224	5473	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of prazosin on platelet_aggregation and plasma beta-thromboglobulin in essential hypertension .
21525724	0	prazosin	20,28	c-Fos	61,66	prazosin	c-Fos	MESH:D011224	314322(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effect of long-term prazosin and yohimbine administration on c-Fos expression in spinal neurons : inhibitory effect of alpha-1 and alpha-2 adrenoceptors on afferents from the lower urinary tract .
7023672	0	prazosin	10,18	renin	44,49	prazosin	renin	MESH:D011224	5972	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|compound|END_ENTITY	Effect of prazosin and oxprenolol on plasma renin activity and blood pressure in patients with essential hypertension .
975613	0	prazosin	44,52	renin	77,82	prazosin	renin	MESH:D011224	403838(Tax:9615)	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Differing effects of the vasodilator drugs , prazosin and diazoxide on plasma renin activity in the dog .
7032827	0	prazosin	19,27	renin_and_angiotensin_II	75,99	prazosin	renin and angiotensin II	MESH:D011224	5972;183	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of oral prazosin on blood pressure and plasma concentrations of renin_and_angiotensin_II in man .
17666808	0	prednisolone	36,48	IL-1beta	0,8	prednisolone	IL-1beta	MESH:D011239	3553	Chemical	Gene	effect|nmod|START_ENTITY effect|amod|END_ENTITY	IL-1beta genotype-related effect of prednisolone on IL-1beta production in human peripheral blood mononuclear cells under acute inflammation .
17666808	0	prednisolone	36,48	IL-1beta	52,60	prednisolone	IL-1beta	MESH:D011239	3553	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|production production|compound|END_ENTITY	IL-1beta genotype-related effect of prednisolone on IL-1beta production in human peripheral blood mononuclear cells under acute inflammation .
8067791	0	prednisolone	108,120	Interleukin-1_alpha	0,19	prednisolone	Interleukin-1 alpha	MESH:D011239	3552	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|END_ENTITY	Interleukin-1_alpha , soluble interleukin-2 receptor , and IgG concentrations in cystic_fibrosis treated with prednisolone .
11123172	0	prednisolone	17,29	MUC5AC	50,56	prednisolone	MUC5AC	MESH:D011239	4586	Chemical	Gene	START_ENTITY|nmod|secretion secretion|nmod|END_ENTITY	The influence of prednisolone on the secretion of MUC5AC from TH29-MTX cell culture INTRODUCTION : Glucocorticoids have been used in the treatment of otitis media with effusion with promising but inconsistent resluts .
12379510	0	prednisolone	74,86	P-glycoprotein	35,49	prednisolone	P-glycoprotein	MESH:D011239	5243	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of the efflux transporter P-glycoprotein in brain penetration of prednisolone .
3899618	0	prednisolone	81,93	insulin_receptor	12,28	prednisolone	insulin receptor	MESH:D011239	3643	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|END_ENTITY	Erythrocyte insulin_receptor and glucose tolerance test in children treated with prednisolone .
12580879	0	prednisolone	13,25	mucin	46,51	prednisolone	mucin	MESH:D011239	100508689	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|secretion secretion|nmod|END_ENTITY	Influence of prednisolone on the secretion of mucin from the HT29-MTX cell line .
3382764	0	prednisolone	11,23	sex_hormone_binding_globulin	27,55	prednisolone	sex hormone binding globulin	MESH:D011239	6462	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of prednisolone on sex_hormone_binding_globulin during primary endocrine treatment of advanced_breast_cancer .
3427792	0	prednisolone	10,22	thyroglobulin	47,60	prednisolone	thyroglobulin	MESH:D011239	7038	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|level level|compound|END_ENTITY	Effect of prednisolone and salicylate on serum thyroglobulin level in patients with subacute_thyroiditis .
22677619	0	prednisolone	110,122	upregulated_gene_4	36,54	prednisolone	upregulated gene 4	MESH:D011239	55665	Chemical	Gene	response|compound|START_ENTITY END_ENTITY|nmod|response	Higher expression of the novel gene upregulated_gene_4 in two acute_lymphoblastic_leukemia patients with poor prednisolone response .
3142918	0	prednisone	14,24	GH	44,46	prednisone	GH	MESH:D011241	2688	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|response response|appos|END_ENTITY	Inhibition by prednisone of growth_hormone -LRB- GH -RRB- response to GH-releasing hormone in normal men .
7520318	0	prednisone	34,44	GH	58,60	prednisone	GH	MESH:D011241	2688	Chemical	Gene	treatment|compound|START_ENTITY treatment|nmod|END_ENTITY	Effects of alternate-day or daily prednisone treatment on GH and cortisol levels in growth-retarded children after renal transplantation .
10090131	0	prednisone	69,79	GHRH	38,42	prednisone	GHRH	MESH:D011241	2691	Chemical	Gene	treatment|compound|START_ENTITY END_ENTITY|nmod|treatment	IGF-I levels rise and GH responses to GHRH decrease during long-term prednisone treatment in man .
16160912	0	prednisone	37,47	IL-13	75,80	prednisone	IL-13	MESH:D011241	3596	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|secretion secretion|compound|END_ENTITY	The combined effects of zafirlukast , prednisone , and inhaled budesonide on IL-13 and IFN-gamma secretion .
18514101	0	prednisone	127,137	Multidrug_resistance-1	0,22	prednisone	Multidrug resistance-1	MESH:D011241	5243	Chemical	Gene	treatment|amod|START_ENTITY effect|nmod|treatment END_ENTITY|dep|effect	Multidrug_resistance-1 in T lymphocytes and natural killer cells of adults with idiopathic_thrombocytopenic_purpura : effect of prednisone treatment .
11353432	0	prednisone	10,20	TGF-beta1	24,33	prednisone	TGF-beta1	MESH:D011241	21803(Tax:10090)	Chemical	Gene	Impact|nmod|START_ENTITY Impact|nmod|END_ENTITY	Impact of prednisone on TGF-beta1 and collagen in diaphragm muscle from mdx mice .
8957747	0	prednisone	24,34	growth_hormone	48,62	prednisone	growth hormone	MESH:D011241	2688	Chemical	Gene	treatment|compound|START_ENTITY effect|nmod|treatment effect|nmod|END_ENTITY	The effect of long-term prednisone treatment on growth_hormone and insulin-like_growth_factor-1 .
1159064	0	prednisone	21,31	insulin	35,42	prednisone	insulin	MESH:D011241	3630	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Inhibitory effect of prednisone on insulin secretion in man : model for duplication of blood glucose concentration .
1263838	0	prednisone	126,136	insulin	15,22	prednisone	insulin	MESH:D011241	3630	Chemical	Gene	therapy|amod|START_ENTITY effect|nmod|therapy levels|dep|effect levels|compound|END_ENTITY	Free and total insulin levels in a patient with insulin-resistant_diabetes_mellitus and chronic_lymphatic_leukemia : effect of prednisone therapy .
19738036	0	prednisone	11,21	insulin	38,45	prednisone	insulin	MESH:D011241	3630	Chemical	Gene	use|compound|START_ENTITY antagonizes|nsubj|use antagonizes|dobj|effect effect|nmod:poss|END_ENTITY	Short-term prednisone use antagonizes insulin 's anabolic effect on muscle protein and glucose metabolism in young healthy people .
20497628	0	prednisone	33,43	insulin	47,54	prednisone	insulin	MESH:D011241	3630	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|resistance resistance|compound|END_ENTITY	Effects of low or medium-dose of prednisone on insulin resistance in patients with systemic_lupus_erythematosus .
21973241	0	prednisone	172,182	insulin	240,247	prednisone	insulin	MESH:D011241	3630	Chemical	Gene	treatment|compound|START_ENTITY fatty_acid|nmod|treatment fatty_acid|dobj|evidence evidence|nmod|effects effects|nmod|secretion secretion|compound|END_ENTITY	Twenty-four-hour profiles of plasma glucose , insulin , C-peptide and free fatty_acid in subjects with varying degrees of glucose_tolerance following short-term , medium-dose prednisone -LRB- 20 mg/day -RRB- treatment : evidence for differing effects on insulin secretion and action .
21973241	0	prednisone	172,182	insulin	45,52	prednisone	insulin	MESH:D011241	3630	Chemical	Gene	treatment|compound|START_ENTITY fatty_acid|nmod|treatment fatty_acid|nsubj|profiles profiles|nmod|glucose glucose|appos|END_ENTITY	Twenty-four-hour profiles of plasma glucose , insulin , C-peptide and free fatty_acid in subjects with varying degrees of glucose_tolerance following short-term , medium-dose prednisone -LRB- 20 mg/day -RRB- treatment : evidence for differing effects on insulin secretion and action .
2571541	0	prednisone	58,68	insulin	16,23	prednisone	insulin	MESH:D011241	3630	Chemical	Gene	Contribution|nmod|START_ENTITY Contribution|nmod|resistance resistance|compound|END_ENTITY	Contribution of insulin resistance to catabolic effect of prednisone on leucine metabolism in humans .
7973537	0	prednisone	41,51	insulin	63,70	prednisone	insulin	MESH:D011241	3630	Chemical	Gene	START_ENTITY|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- The effect of long-term cyclosporin and prednisone therapy on insulin secretory reserve -RSB- .
1372881	0	prednisone	46,56	interferon_alpha-2A	12,31	prednisone	interferon alpha-2A	MESH:D011241	3440	Chemical	Gene	combined|nmod|START_ENTITY END_ENTITY|acl|combined	Recombinant interferon_alpha-2A combined with prednisone in metastatic renal-cell_carcinoma : treatment results , serum interferon levels and the development of antibodies .
9024520	0	prednisone	53,63	interferon_alpha-2a	27,46	prednisone	interferon alpha-2a	MESH:D011241	3440	Chemical	Gene	therapy|amod|START_ENTITY END_ENTITY|nmod|therapy	Successful management with interferon_alpha-2a after prednisone therapy failure in an infant with a giant cavernous hemangioma .
9697790	0	prednisone	10,20	prostate-specific_antigen	24,49	prednisone	prostate-specific antigen	MESH:D011241	354	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of prednisone on prostate-specific_antigen in patients with hormone-refractory_prostate_cancer .
20171174	0	pregnane	24,32	CYP3A4	14,20	pregnane	CYP3A4	CHEBI:8386	1576	Chemical	Gene	receptor|amod|START_ENTITY END_ENTITY|nmod|receptor	Regulation of CYP3A4 by pregnane X receptor : The role of nuclear receptors competing for response element binding .
24316275	0	pregnane	87,95	PXR	99,102	pregnane	PXR	CHEBI:8386	8856	Chemical	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Profiling of enantiopure drugs towards aryl_hydrocarbon -LRB- AhR -RRB- , glucocorticoid -LRB- GR -RRB- and pregnane X -LRB- PXR -RRB- receptors in human reporter cell lines .
25039279	0	pregnane	18,26	PXR	52,55	pregnane	PXR	CHEBI:8386	8856	Chemical	Gene	X|amod|START_ENTITY END_ENTITY|nsubj|X	Evidence that the pregnane X and retinoid receptors PXR , RAR and RXR may regulate transcription of the transporter hOCT1 in chronic_myeloid_leukaemia cells .
11062854	0	pregnenolone	108,120	3_beta-hydroxysteroid_dehydrogenase	37,72	pregnenolone	3 beta-hydroxysteroid dehydrogenase	MESH:D011284	3283	Chemical	Gene	cells|nmod|START_ENTITY activity|nmod|cells activity|amod|END_ENTITY	Increased progesterone secretion and 3_beta-hydroxysteroid_dehydrogenase activity in human cumulus cells by pregnenolone is limited to the high steroidogenic active cumuli .
8240978	0	pregnenolone	111,123	cytochrome_b5	143,156	pregnenolone	cytochrome b5	MESH:D011284	281110(Tax:9913)	Chemical	Gene	START_ENTITY|nmod|presence presence|nmod|END_ENTITY	Cytochrome_P450c17 from porcine and bovine adrenal catalyses the formation of 5,16-androstadien-3 _ beta-ol from pregnenolone in the presence of cytochrome_b5 .
8947841	0	pregnenolone	68,80	cytochrome_p-450scc	102,121	pregnenolone	cytochrome p-450scc	MESH:D011284	1583	Chemical	Gene	START_ENTITY|nmod|system system|amod|END_ENTITY	Identification of intermediates in the conversion of cholesterol to pregnenolone with a reconstituted cytochrome_p-450scc system : accumulation of the intermediate modulated by the adrenodoxin level .
19359405	6	pregnenolone_16alpha-carbonitrile	1139,1172	mice	1224,1228	pregnenolone 16alpha-carbonitrile	Ces6	MESH:D011285	102022(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nmod|END_ENTITY	Here , we show that a gene encoding a member of the CES2 subtype of liver - and intestine-enriched CES enzymes , called Ces6 , is induced after treatment with pregnenolone_16alpha-carbonitrile in a PXR-dependent manner in duodenum and liver in mice .
22355414	0	prelamin_A	51,61	ZMPSTE24	65,73	prelamin A	ZMPSTE24	null	10269	Chemical	Gene	Requirements|nmod|START_ENTITY Requirements|nmod|END_ENTITY	Requirements for efficient proteolytic cleavage of prelamin_A by ZMPSTE24 .
6108219	0	prenalterol	34,45	adrenergic_beta-1-receptor	53,79	prenalterol	adrenergic beta-1-receptor	MESH:D011294	153	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Immediate haemodynamic effects of prenalterol , a new adrenergic_beta-1-receptor agonist , in healthy volunteers .
6102914	0	prenalterol	104,115	beta_1-adrenoceptor	75,94	prenalterol	beta 1-adrenoceptor	MESH:D011294	153	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|END_ENTITY	Metabolic and haemodynamic effects and pharmacokinetics of a new selective beta_1-adrenoceptor agonist , prenalterol , in man .
6114866	0	prenalterol	77,88	beta_1-adrenoceptor	48,67	prenalterol	beta 1-adrenoceptor	MESH:D011294	153	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Pharmacokinetic studies in man of the selective beta_1-adrenoceptor agonist , prenalterol .
6124405	0	prenalterol	71,82	beta_1-adrenoceptor	43,62	prenalterol	beta 1-adrenoceptor	MESH:D011294	11554(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|disposition disposition|nmod|agonist agonist|amod|END_ENTITY	The metabolic disposition of the selective beta_1-adrenoceptor agonist prenalterol in mice , rats , dogs , and humans .
3542308	0	prenalterol	35,46	renin	57,62	prenalterol	renin	MESH:D011294	5972	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Effect of the partial beta-agonist prenalterol on plasma renin activity in patients with left_ventricular_failure .
12506405	0	prenyl_pyrophosphates	11,32	PKCgamma	51,59	prenyl pyrophosphates	PKCgamma	null	5582	Chemical	Gene	START_ENTITY|nmod|the the|nmod|END_ENTITY	Effects of prenyl_pyrophosphates on the binding of PKCgamma with RACK1 .
19288405	0	prenylated_flavonoids	38,59	15-Lipoxygenase	0,15	prenylated flavonoids	15-Lipoxygenase	null	246	Chemical	Gene	effects|nmod|START_ENTITY effects|amod|END_ENTITY	15-Lipoxygenase inhibitory effects of prenylated_flavonoids from Erythrina senegalensis .
24054487	0	prenylated_isoflavones	46,68	neuraminidase	10,23	prenylated isoflavones	neuraminidase	null	4758	Chemical	Gene	effects|nmod|START_ENTITY effects|amod|END_ENTITY	Bacterial neuraminidase inhibitory effects of prenylated_isoflavones from roots of Flemingia philippinensis .
1986735	0	prenylflavone	2,15	arachidonate_5-lipoxygenase	31,58	prenylflavone	arachidonate 5-lipoxygenase	null	240	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|amod|END_ENTITY	A prenylflavone , artonin_E , as arachidonate_5-lipoxygenase inhibitor .
2697638	0	prephenate	24,34	TYR1	64,68	prephenate	TYR1	MESH:C005550	852464(Tax:4932)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of the prephenate dehydrogenase-encoding gene , TYR1 , from Saccharomyces_cerevisiae .
11259546	0	primaquine	63,73	CYP1A1	53,59	primaquine	CYP1A1	MESH:D011319	1543	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional and post-translational regulation of CYP1A1 by primaquine .
25518709	0	primaquine	31,41	CYP2D6	51,57	primaquine	CYP2D6	MESH:D011319	1565	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|nmod|END_ENTITY	Enantioselective metabolism of primaquine by human CYP2D6 .
7835226	0	primary_amine	45,58	monoamine_oxidase_B	59,78	primary amine	monoamine oxidase B	CHEBI:32877	403451(Tax:9615)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	Novel carbamate metabolites of mofegiline , a primary_amine monoamine_oxidase_B inhibitor , in dogs and humans .
6186243	0	primary_amines	86,100	alpha_2-macroglobulin	47,68	primary amines	alpha 2-macroglobulin	CHEBI:32877	2	Chemical	Gene	Evidence|nmod|START_ENTITY Evidence|nmod|END_ENTITY	Evidence for similar conformational changes in alpha_2-macroglobulin on reaction with primary_amines or proteolytic enzymes .
16708425	0	pristane	11,19	cytochrome_P450	23,38	pristane	cytochrome P450	MESH:C009042	25251(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|amod|END_ENTITY	Effects of pristane on cytochrome_P450 isozyme expression in rat tissues .
7720780	0	pristinamycin_IA	15,31	P-glycoprotein	37,51	pristinamycin IA	P-glycoprotein	MESH:D025381	5243	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of pristinamycin_IA with P-glycoprotein in human intestinal epithelial cells .
9296364	0	pro-pro-diphenyl-phosphonate	58,86	dipeptidyl_peptidase_IV	22,45	pro-pro-diphenyl-phosphonate	dipeptidyl peptidase IV	null	100341424(Tax:9986)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	In vivo inhibition of dipeptidyl_peptidase_IV activity by pro-pro-diphenyl-phosphonate -LRB- Prodipine -RRB- .
16789503	0	pro12Ala	27,35	PPARgamma	39,48	pro12Ala	PPARgamma	null	5468	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	-LSB- Influence of polymorphism pro12Ala of PPARgamma gene on endothelium destruction in patients with diabetes_mellitus t. 2 -RSB- .
22678031	0	proanthocyanidin	59,75	ANR	44,47	proanthocyanidin	ANR	MESH:C013221	100232981(Tax:29760)	Chemical	Gene	pathway|nmod|START_ENTITY pathway|compound|END_ENTITY	An integrated approach to demonstrating the ANR pathway of proanthocyanidin biosynthesis in plants .
17208963	0	proanthocyanidin	54,70	VvMYBPA1	35,43	proanthocyanidin	VvMYBPA1	MESH:C013221	100232899(Tax:29760)	Chemical	Gene	synthesis|compound|START_ENTITY regulates|dobj|synthesis regulates|nsubj|END_ENTITY	The grapevine transcription factor VvMYBPA1 regulates proanthocyanidin synthesis during fruit development .
26051626	0	proanthocyanidins	8,25	Nampt	54,59	proanthocyanidins	Nampt	MESH:D044945	297508(Tax:10116)	Chemical	Gene	modulate|nsubj|START_ENTITY modulate|dobj|expression expression|amod|END_ENTITY	Dietary proanthocyanidins modulate BMAL1 acetylation , Nampt expression and NAD levels in rat liver .
17313938	0	proanthocyanidins	10,27	cyclooxygenase-2	36,52	proanthocyanidins	cyclooxygenase-2	MESH:D044945	19225(Tax:10090)	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|expression expression|amod|END_ENTITY	Green tea proanthocyanidins inhibit cyclooxygenase-2 expression in LPS-activated mouse macrophages : molecular mechanisms and structure-activity relationship .
20143255	0	proanthocyanidins	19,36	cyclooxygenase-2	57,73	proanthocyanidins	cyclooxygenase-2	MESH:D044945	19225(Tax:10090)	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|expression expression|amod|END_ENTITY	Dietary grape seed proanthocyanidins inhibit UVB-induced cyclooxygenase-2 expression and other inflammatory mediators in UVB-exposed skin and skin_tumors of SKH-1 hairless mice .
21803362	0	proanthocyanidins	57,74	pancreatic_lipase	151,168	proanthocyanidins	pancreatic lipase	MESH:D044945	100034202(Tax:9796)	Chemical	Gene	analysis|nmod|START_ENTITY analysis|nmod|END_ENTITY	Structural analysis of A-type or B-type highly polymeric proanthocyanidins by thiolytic degradation and the implication in their inhibitory effects on pancreatic_lipase .
16112700	0	proatherocytin	73,87	PAR1	116,120	proatherocytin	PAR1	null	2149	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Characterization of a novel protein from Proatheris superciliaris venom : proatherocytin , a 34-kDa platelet receptor PAR1 agonist .
23128665	0	probucol	11,19	BMP-2	46,51	probucol	BMP-2	MESH:D011341	650	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of probucol on angiotensin_II-induced BMP-2 expression in human umbilical vein endothelial cells .
8447724	0	probucol	148,156	CETP	130,134	probucol	LCAT	MESH:D011341	3931	Chemical	Gene	activity|nmod|START_ENTITY activity|appos|END_ENTITY	Decrease of plasma large , light LDL -LRB- LDL1 -RRB- , HDL2 and HDL3 levels with concomitant increase of cholesteryl_ester_transfer_protein -LRB- CETP -RRB- activity by probucol in type_II_hyperlipoproteinemia .
9714785	0	probucol	23,31	CETP	71,75	probucol	CETP	MESH:D011341	100758852	Chemical	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Mechanism of action of probucol on cholesteryl_ester_transfer_protein -LRB- CETP -RRB- mRNA in a Chinese_hamster ovary cell line that had been stably transfected with a human CETP gene .
1872919	0	probucol	53,61	IL-1_beta	14,23	probucol	IL-1 beta	MESH:D011341	3553	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|expression expression|compound|END_ENTITY	Inhibition of IL-1_beta expression in THP-1 cells by probucol and tocopherol .
16766063	0	probucol	10,18	SR-BI	76,81	probucol	SR-BI	MESH:D011341	100009590(Tax:9986)	Chemical	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Effect of probucol on HDL metabolism and class B type I scavenger receptor -LRB- SR-BI -RRB- expression in the liver of hypercholesterolemic rabbits .
25983325	0	probucol	64,72	SR-BI	76,81	probucol	SR-BI	MESH:D011341	20778(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Spontaneous and diet-aggravated hemolysis and its correction by probucol in SR-BI knockout mice with LDL-R deficiency .
11223433	0	probucol	24,32	VCAM-1	71,77	probucol	VCAM-1	MESH:D011341	7412	Chemical	Gene	START_ENTITY|nmod|expression expression|appos|END_ENTITY	Selective inhibition by probucol of vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- expression in human vascular endothelial cells .
12946703	0	probucol	30,38	apolipoprotein_E	49,65	probucol	apolipoprotein E	MESH:D011341	25728(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|production production|amod|END_ENTITY	The cholesterol-lowering drug probucol increases apolipoprotein_E production in the hippocampus of aged rats : implications for Alzheimer 's _ disease .
14642415	0	probucol	32,40	cholesteryl_ester_transfer_protein	53,87	probucol	cholesteryl ester transfer protein	MESH:D011341	1071	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|nmod|deficiency deficiency|compound|END_ENTITY	Modulation of HDL metabolism by probucol in complete cholesteryl_ester_transfer_protein deficiency .
1903061	0	probucol	61,69	cholesteryl_ester_transfer_protein	19,53	probucol	cholesteryl ester transfer protein	MESH:D011341	1071	Chemical	Gene	treatment|amod|START_ENTITY Increase|nmod|treatment Increase|nmod|END_ENTITY	Increase in plasma cholesteryl_ester_transfer_protein during probucol treatment .
8447724	0	probucol	148,156	cholesteryl_ester_transfer_protein	94,128	probucol	cholesteryl ester transfer protein	MESH:D011341	1071	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Decrease of plasma large , light LDL -LRB- LDL1 -RRB- , HDL2 and HDL3 levels with concomitant increase of cholesteryl_ester_transfer_protein -LRB- CETP -RRB- activity by probucol in type_II_hyperlipoproteinemia .
8509722	0	probucol	70,78	cholesteryl_ester_transfer_protein	15,49	probucol	cholesteryl ester transfer protein	MESH:D011341	1071	Chemical	Gene	treatment|amod|START_ENTITY response|nmod|treatment mRNA|nmod|response mRNA|compound|END_ENTITY	Adipose tissue cholesteryl_ester_transfer_protein mRNA in response to probucol treatment : cholesterol and species dependence .
1632848	0	probucol	58,66	familial_hypercholesterolemia	80,109	probucol	familial hypercholesterolemia	MESH:D011341	3949	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|END_ENTITY	Non-macrophage-related accumulation of cholesterol during probucol treatment in familial_hypercholesterolemia : report of two cases .
19060422	0	probucol	10,18	familial_hypercholesterolemia	116,145	probucol	familial hypercholesterolemia	MESH:D011341	3949	Chemical	Gene	treatment|amod|START_ENTITY prevents|nsubj|treatment prevents|dobj|events events|dep|study study|nmod|patients patients|nmod|END_ENTITY	Long-term probucol treatment prevents secondary cardiovascular events : a cohort study of patients with heterozygous familial_hypercholesterolemia in Japan .
3081013	0	probucol	10,18	familial_hypercholesterolemia	101,130	probucol	familial hypercholesterolemia	MESH:D011341	3949	Chemical	Gene	treatment|amod|START_ENTITY Effect|nmod|treatment Effect|nmod|END_ENTITY	Effect of probucol treatment on lipoprotein cholesterol and drug levels in blood and lipoproteins in familial_hypercholesterolemia .
6615580	0	probucol	11,19	familial_hypercholesterolemia	43,72	probucol	familial hypercholesterolemia	MESH:D011341	3949	Chemical	Gene	cases|amod|START_ENTITY Effects|nmod|cases Effects|nmod|END_ENTITY	Effects of probucol on homozygous cases of familial_hypercholesterolemia .
8026274	0	probucol	104,112	familial_hypercholesterolemia	42,71	probucol	familial hypercholesterolemia	MESH:D011341	3949	Chemical	Gene	composition|nmod|START_ENTITY composition|nmod|END_ENTITY	Biliary lipid composition in heterozygous familial_hypercholesterolemia and influence of treatment with probucol .
24211675	0	probucol	11,19	hERG	31,35	probucol	hERG	MESH:D011341	2078	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effects of probucol , a typical hERG expression inhibitor , on in vivo QT_interval_prolongation in conscious dogs .
26512244	0	probucol	10,18	insulin	22,29	probucol	insulin	MESH:D011341	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|resistance resistance|compound|END_ENTITY	Effect of probucol on insulin resistance in patients with non-diabetic chronic_kidney_disease .
3260741	0	probucol	14,22	interleukin_1	26,39	probucol	interleukin 1	MESH:D011341	111343(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	Inhibition by probucol of interleukin_1 secretion and its implication in atherosclerosis .
19220660	0	probucol	11,19	tumor_necrosis_factor-alpha	31,58	probucol	tumor necrosis factor-alpha	MESH:D011341	24835(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|amod|END_ENTITY	Effects of probucol on hepatic tumor_necrosis_factor-alpha , interleukin-6 and adiponectin_receptor-2 expression in diabetic rats .
11223433	0	probucol	24,32	vascular_cell_adhesion_molecule-1	36,69	probucol	vascular cell adhesion molecule-1	MESH:D011341	7412	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Selective inhibition by probucol of vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- expression in human vascular endothelial cells .
15795105	0	procainamide	28,40	CD3-zeta_chain	44,58	procainamide	CD3-zeta chain	MESH:D011342	919	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effect of 5-azacytidine and procainamide on CD3-zeta_chain expression in Jurkat T cells .
23809695	4	procainamide	699,711	DNMT1	682,687	procainamide	DNMT1	MESH:D011342	13433(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	FINDINGS : Our data indicated that the use of an unspecific DNMT inhibitor -LRB- 5aza-2deoxycytidine -RRB- , a DNMT1 inhibitor -LRB- procainamide -RRB- or peptides disrupting the DNMT1/PCNA , DNMT1/EZH2 , DNMT1/HDAC1 , DNMT1/DNMT3b and DNMT1/HP1 interactions promoted or enhanced in vivo tumorigenesis in a mouse glioma model .
2433967	0	procainamide	122,134	N-acetylprocainamide	79,99	procainamide	N-acetylprocainamide	MESH:D011342	8775	Chemical	Gene	metabolite|nmod|START_ENTITY metabolite|amod|END_ENTITY	Arrhythmia control by selective lengthening of cardiac repolarization : role of N-acetylprocainamide , active metabolite of procainamide .
11922660	0	procaine	17,25	fos	59,62	procaine	fos	MESH:D011343	314322(Tax:10116)	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|END_ENTITY	Intrapericardial procaine affects volume expansion-induced fos immunoreactivity in unanesthetized rats .
4597423	0	procaine	32,40	insulin	58,65	procaine	insulin	MESH:D011343	100009181(Tax:9986)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Effect of the local anesthetics procaine and lidocaine on insulin secretion from rabbit pancreas pieces .
10530583	0	procalcitonin	14,27	C-reactive_protein	33,51	procalcitonin	C-reactive protein	MESH:C029100	1401	Chemical	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|END_ENTITY	Comparison of procalcitonin with C-reactive_protein , interleukin_6 and interferon-alpha for differentiation of bacterial vs. viral_infections .
12031922	0	procalcitonin	20,33	C-reactive_protein	66,84	procalcitonin	C-reactive protein	MESH:C029100	1401	Chemical	Gene	levels|amod|START_ENTITY value|nmod|levels value|nmod|END_ENTITY	Diagnostic value of procalcitonin serum levels in comparison with C-reactive_protein in allogeneic stem_cell_transplantation .
12749651	0	procalcitonin	6,19	C-reactive_protein	73,91	procalcitonin	C-reactive protein	MESH:C029100	1401	Chemical	Gene	START_ENTITY|dep|comparison comparison|nmod|count count|amod|END_ENTITY	Serum procalcitonin in children with suspected sepsis : a comparison with C-reactive_protein and neutrophil count .
15069709	0	procalcitonin	20,33	C-reactive_protein	0,18	procalcitonin	C-reactive protein	MESH:C029100	1401	Chemical	Gene	factor|dep|START_ENTITY factor|amod|END_ENTITY	C-reactive_protein , procalcitonin , interleukin-6 , vascular endothelial growth factor and oxidative metabolites in diagnosis of infection and staging in patients with gastric_cancer .
15221617	0	procalcitonin	87,100	C-reactive_protein	133,151	procalcitonin	C-reactive protein	MESH:C029100	1401	Chemical	Gene	hematological_malignancies|amod|START_ENTITY patients|nmod|hematological_malignancies bacteremia|nmod|patients Markers|nmod|bacteremia reliable|nsubj|Markers reliable|nmod|END_ENTITY	Markers of bacteremia in febrile neutropenic patients with hematological_malignancies : procalcitonin and IL-6 are more reliable than C-reactive_protein .
15276911	0	procalcitonin	48,61	C-reactive_protein	180,198	procalcitonin	C-reactive protein	MESH:C029100	1401	Chemical	Gene	measurement|nmod|START_ENTITY evaluation|nmod|measurement evaluation|dep|study study|nmod|patients patients|nmod|concentrations concentrations|nmod|END_ENTITY	Clinical evaluation of the measurement of serum procalcitonin : comparative study of procalcitonin and serum_amyloid_A_protein in patients with high and low concentrations of serum C-reactive_protein .
15276911	0	procalcitonin	84,97	C-reactive_protein	180,198	procalcitonin	C-reactive protein	MESH:C029100	1401	Chemical	Gene	study|nmod|START_ENTITY study|nmod|patients patients|nmod|concentrations concentrations|nmod|END_ENTITY	Clinical evaluation of the measurement of serum procalcitonin : comparative study of procalcitonin and serum_amyloid_A_protein in patients with high and low concentrations of serum C-reactive_protein .
16896829	0	procalcitonin	40,53	C-reactive_protein	20,38	procalcitonin	C-reactive protein	MESH:C029100	1401	Chemical	Gene	alpha|dep|START_ENTITY alpha|compound|END_ENTITY	Evaluation of serum C-reactive_protein , procalcitonin , tumor necrosis factor alpha , and interleukin-10 levels as diagnostic and prognostic parameters in patients with community-acquired sepsis , severe_sepsis , and septic_shock .
17362525	0	procalcitonin	34,47	C-reactive_protein	14,32	procalcitonin	C-reactive protein	MESH:C029100	1401	Chemical	Gene	receptor|dep|START_ENTITY receptor|compound|END_ENTITY	Use of plasma C-reactive_protein , procalcitonin , neutrophils , macrophage_migration_inhibitory_factor , soluble urokinase-type plasminogen activator receptor , and soluble triggering receptor expressed on myeloid cells-1 in combination to diagnose infections : a prospective study .
19747215	0	procalcitonin	24,37	C-reactive_protein	4,22	procalcitonin	C-reactive protein	MESH:C029100	1401	Chemical	Gene	measurements|compound|START_ENTITY END_ENTITY|appos|measurements	Can C-reactive_protein , procalcitonin and mid-regional pro-atrial natriuretic peptide measurements guide choice of in-patient or out-patient care in acute pyelonephritis ?
20087955	0	procalcitonin	3,16	C-reactive_protein	29,47	procalcitonin	C-reactive protein	MESH:C029100	1401	Chemical	Gene	better|nsubj|START_ENTITY better|nmod|END_ENTITY	Is procalcitonin better than C-reactive_protein for early diagnosis of bacterial_pneumonia in children ?
20192974	0	procalcitonin	6,19	C-reactive_protein	21,39	procalcitonin	C-reactive protein	MESH:C029100	1401	Chemical	Gene	START_ENTITY|appos|levels levels|amod|END_ENTITY	Serum procalcitonin , C-reactive_protein and white blood cell levels following hypothermia after cardiac_arrest : a retrospective cohort study .
21636351	0	procalcitonin	82,95	C-reactive_protein	62,80	procalcitonin	C-reactive protein	MESH:C029100	1401	Chemical	Gene	START_ENTITY|nsubj|value value|nmod|comparison comparison|nmod|END_ENTITY	Diagnostic value of resistin and visfatin , in comparison with C-reactive_protein , procalcitonin and interleukin-6 in neonatal_sepsis .
23712521	0	procalcitonin	77,90	C-reactive_protein	23,41	procalcitonin	C-reactive protein	MESH:C029100	1401	Chemical	Gene	levels|nmod|START_ENTITY END_ENTITY|acl:relcl|levels	Substantially elevated C-reactive_protein -LRB- CRP -RRB- , together with low levels of procalcitonin -LRB- PCT -RRB- , contributes to diagnosis of fungal_infection in immunocompromised patients .
25963492	0	procalcitonin	14,27	C-reactive_protein	29,47	procalcitonin	C-reactive protein	MESH:C029100	1401	Chemical	Gene	serum_amyloid_A|amod|START_ENTITY serum_amyloid_A|amod|END_ENTITY	Evaluation of procalcitonin , C-reactive_protein , interleukin-6 _ serum_amyloid_A as diagnostic biomarkers of bacterial_infection in febrile patients .
26190096	0	procalcitonin	86,99	C-reactive_protein	66,84	procalcitonin	C-reactive protein	MESH:C029100	1401	Chemical	Gene	Comparison|appos|START_ENTITY Comparison|nmod|efficacy efficacy|nmod|parameters parameters|nmod|END_ENTITY	Comparison of the efficacy of new leukocyte parameters with serum C-reactive_protein , procalcitonin , interleukin-6 levels in the diagnosis of neonatal_sepsis .
15069709	0	procalcitonin	20,33	interleukin-6	35,48	procalcitonin	interleukin-6	MESH:C029100	3569	Chemical	Gene	factor|dep|START_ENTITY factor|amod|END_ENTITY	C-reactive_protein , procalcitonin , interleukin-6 , vascular endothelial growth factor and oxidative metabolites in diagnosis of infection and staging in patients with gastric_cancer .
20495248	0	procalcitonin	20,33	interleukin-6	47,60	procalcitonin	interleukin-6	MESH:C029100	3569	Chemical	Gene	value|nmod|START_ENTITY and/or|nsubj|value and/or|dobj|levels levels|amod|END_ENTITY	Prognostic value of procalcitonin -LRB- PCT -RRB- and/or interleukin-6 -LRB- IL-6 -RRB- plasma levels after multiple trauma for the development of multi_organ_dysfunction_syndrome -LRB- MODS -RRB- or sepsis .
20669762	0	procalcitonin	6,19	interleukin-6	21,34	procalcitonin	interleukin-6	MESH:C029100	3569	Chemical	Gene	molecule-1|compound|START_ENTITY molecule-1|amod|END_ENTITY	Serum procalcitonin , interleukin-6 , soluble intercellular adhesin molecule-1 and IgG to short-chain exocellular lipoteichoic acid as predictors of infection_in_total_joint_prosthesis_revision .
25963492	0	procalcitonin	14,27	interleukin-6	49,62	procalcitonin	interleukin-6	MESH:C029100	3569	Chemical	Gene	serum_amyloid_A|amod|START_ENTITY serum_amyloid_A|amod|END_ENTITY	Evaluation of procalcitonin , C-reactive_protein , interleukin-6 _ serum_amyloid_A as diagnostic biomarkers of bacterial_infection in febrile patients .
26190096	0	procalcitonin	86,99	interleukin-6	101,114	procalcitonin	interleukin-6	MESH:C029100	3569	Chemical	Gene	Comparison|appos|START_ENTITY Comparison|appos|levels levels|amod|END_ENTITY	Comparison of the efficacy of new leukocyte parameters with serum C-reactive_protein , procalcitonin , interleukin-6 levels in the diagnosis of neonatal_sepsis .
7519972	0	procarbazine	24,36	O6-alkylguanine-DNA_alkyltransferase	133,169	procarbazine	O6-alkylguanine-DNA alkyltransferase	MESH:D011344	25332(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Differential effects of procarbazine and methylnitrosourea on the accumulation of O6-methylguanine and the depletion and recovery of O6-alkylguanine-DNA_alkyltransferase in rat tissues .
7857702	0	procarbazine	18,30	POC	59,62	procarbazine	POC	MESH:D011344	5443	Chemical	Gene	trial|nmod|START_ENTITY trial|appos|END_ENTITY	Phase II trial of procarbazine , vincristine and lomustine -LRB- POC -RRB- chemotherapy in metastatic cutaneous_malignant_melanoma .
23427001	0	procarbazine_hydrochloride	82,108	CD-1	112,116	procarbazine hydrochloride	CD-1	MESH:D011344	100124526(Tax:9823)	Chemical	Gene	START_ENTITY|nmod|mice mice|compound|END_ENTITY	Flow cytometric analysis of Pig-a gene mutation and chromosomal damage induced by procarbazine_hydrochloride in CD-1 mice .
20652827	0	procaterol	23,33	IP-10	51,56	procaterol	IP-10	MESH:D017265	3627	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|nmod|END_ENTITY	Suppressive effects of procaterol on expression of IP-10 / CXCL_10 and RANTES/CCL _ 5 by bronchial epithelial cells .
26738	0	procaterol	11,21	beta2-adrenoceptor	40,58	procaterol	beta2-adrenoceptor	MESH:D017265	154	Chemical	Gene	Actions|nmod|START_ENTITY Actions|appos|stimulant stimulant|amod|END_ENTITY	Actions of procaterol -LRB- OPC-2009 -RRB- , a new beta2-adrenoceptor stimulant , on pulmonary resistance , contractions of the soleus muscle , and cardiovascular system of the anaesthetized cat .
33812	0	procaterol	154,164	beta2-adrenoceptor	182,200	procaterol	beta2-adrenoceptor	MESH:D017265	403910(Tax:9615)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Alterations in blood levels of carbohydrate and lipid metabolites and of cyclic_AMP mediated by beta1 - and beta2-adrenoceptors in beagle_dogs : effects of procaterol , a new selective beta2-adrenoceptor agonist .
2862893	0	procaterol	68,78	beta_2-adrenoceptor	39,58	procaterol	beta 2-adrenoceptor	MESH:D017265	154	Chemical	Gene	agonist|amod|START_ENTITY agonist|amod|END_ENTITY	A comparative study of a new selective beta_2-adrenoceptor agonist , procaterol and salbutamol in asthma .
2894876	0	procaterol	20,30	beta_2-adrenoceptor	34,53	procaterol	beta 2-adrenoceptor	MESH:D017265	403910(Tax:9615)	Chemical	Gene	START_ENTITY|appos|stimulant stimulant|amod|END_ENTITY	Relaxing actions of procaterol , a beta_2-adrenoceptor stimulant , on smooth muscle cells of the dog trachea .
43821	0	procaterol	31,41	beta_2-adrenoceptor	73,92	procaterol	beta 2-adrenoceptor	MESH:D017265	24176(Tax:10116)	Chemical	Gene	START_ENTITY|appos|stimulant stimulant|amod|END_ENTITY	-LSB- Pharmacological properties of procaterol , a newly synthetized , specific beta_2-adrenoceptor stimulant .
7544228	0	procaterol	10,20	beta_2-adrenoceptor	24,43	procaterol	beta 2-adrenoceptor	MESH:D017265	154	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Effect of procaterol , a beta_2-adrenoceptor agonist , on skin whealing response caused by inflammatory mediators in asthmatic children .
7600383	0	procaterol	19,29	beta_2_adrenoceptor	33,52	procaterol	beta 2 adrenoceptor	MESH:D017265	100722663	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Ability of inhaled procaterol , a beta_2_adrenoceptor agonist , to attenuate eicosanoid-induced airflow obstruction and airway microvascular leakage .
9776083	0	procathepsin_B	18,32	cathepsin_B	44,55	procathepsin B	cathepsin B	null	1508	Chemical	Gene	forms|amod|START_ENTITY forms|compound|END_ENTITY	Codistribution of procathepsin_B and mature cathepsin_B forms in human prostate_tumors detected by confocal and immunofluorescence microscopy .
6811447	0	procetofen	10,20	apolipoprotein_A_I	24,42	procetofen	apolipoprotein A I	MESH:D011345	335	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|concentrations concentrations|compound|END_ENTITY	Effect of procetofen on apolipoprotein_A_I and B concentrations in hyperlipoproteinemia .
2460071	0	proctolin	106,115	CGRP	58,62	proctolin	CGRP	MESH:C011536	796	Chemical	Gene	VIP|appos|START_ENTITY VIP|appos|END_ENTITY	Immunohistochemical studies of the neurochemical markers , CGRP , enkephalin , galanin , gamma-MSH , NPY , PHI , proctolin , PTH , somatostatin , SP , VIP , tyrosine hydroxylase and neurofilament in nerves and cells of the human attached_gingiva .
2460071	0	proctolin	106,115	NPY	96,99	proctolin	NPY	MESH:C011536	4852	Chemical	Gene	VIP|appos|START_ENTITY VIP|appos|END_ENTITY	Immunohistochemical studies of the neurochemical markers , CGRP , enkephalin , galanin , gamma-MSH , NPY , PHI , proctolin , PTH , somatostatin , SP , VIP , tyrosine hydroxylase and neurofilament in nerves and cells of the human attached_gingiva .
2460071	0	proctolin	106,115	PTH	117,120	proctolin	PTH	MESH:C011536	5741	Chemical	Gene	VIP|appos|START_ENTITY VIP|appos|END_ENTITY	Immunohistochemical studies of the neurochemical markers , CGRP , enkephalin , galanin , gamma-MSH , NPY , PHI , proctolin , PTH , somatostatin , SP , VIP , tyrosine hydroxylase and neurofilament in nerves and cells of the human attached_gingiva .
2460071	0	proctolin	106,115	gamma-MSH	85,94	proctolin	gamma-MSH	MESH:C011536	5443	Chemical	Gene	VIP|appos|START_ENTITY VIP|appos|END_ENTITY	Immunohistochemical studies of the neurochemical markers , CGRP , enkephalin , galanin , gamma-MSH , NPY , PHI , proctolin , PTH , somatostatin , SP , VIP , tyrosine hydroxylase and neurofilament in nerves and cells of the human attached_gingiva .
15461267	0	procyanidin	21,32	SSTR-2	54,60	procyanidin	SSTR-2	MESH:C017674	54305(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|mRNA mRNA|compound|END_ENTITY	-LSB- Inhibition of grape procyanidin on the expression of SSTR-2 mRNA in the hepatic cells induced by N-nitroso compounds -RSB- .
24625919	0	procyanidin	14,25	STAT1	43,48	procyanidin	STAT1	MESH:C017674	25124(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	The effect of procyanidin on expression of STAT1 in type_2_diabetes_mellitus SD rats with focal cerebral_ischemia .
26037075	0	procyanidin_B1	28,42	THP1	58,62	procyanidin B1	THP1	MESH:C479579	2736	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Anti-inflammatory effect of procyanidin_B1 on LPS-treated THP1 cells via interaction with the TLR4-MD-2 heterodimer and p38 MAPK and NF-kB signaling .
26037075	7	procyanidin_B1	1210,1224	THP1	1240,1244	procyanidin B1	MD-2	MESH:C479579	23643	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	The production of TNF-a was significantly decreased by procyanidin_B1 in LPS-treated THP1 cells -LRB- p < 0.05 -RRB- .
18275936	0	procyanidin_B2	8,22	NF-kappaB	54,63	procyanidin B2	NF-kappaB	MESH:C479580	4790	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Dimeric procyanidin_B2 inhibits constitutively active NF-kappaB in Hodgkin 's _ lymphoma cells independently of the presence of IkappaB mutations .
27051016	0	procyanidine	10,22	VEGFR-2	26,33	procyanidine	VEGFR-2	MESH:C017674	25589(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effect of procyanidine on VEGFR-2 expression and transduction pathway in rat endothelial progenitor cells under high glucose conditions .
25385044	0	procyanidins	9,21	HIF-1a	112,118	procyanidins	HIF-1a	MESH:D044945	3091	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	Oligomer procyanidins -LRB- F2 -RRB- isolated from grape seeds inhibits tumor angiogenesis and cell invasion by targeting HIF-1a in vitro .
19123327	0	procyanidins	22,34	T-bet	115,120	procyanidins	T-bet	MESH:D044945	30009	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nsubj|effect	-LSB- Regulatory effect of procyanidins on the expressions of interferon-gamma , interleukin-12 and transcription factor T-bet mRNA in peripheral blood mononuclear cell of patients with alopecia_areata -RSB- .
19840828	0	procyanidins	39,51	cyclooxygenase-2	55,71	procyanidins	cyclooxygenase-2	MESH:D044945	5743	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effects of Areca catechu L. containing procyanidins on cyclooxygenase-2 expression in vitro and in vivo .
21028873	0	procyanidins	51,63	pancreatic_lipase	28,45	procyanidins	pancreatic lipase	MESH:D044945	5406	Chemical	Gene	Study|nmod|START_ENTITY Study|nmod|interaction interaction|nmod|END_ENTITY	Study of the interaction of pancreatic_lipase with procyanidins by optical and enzymatic methods .
25047167	0	procysteine	10,21	smpd3	119,124	procysteine	smpd3	MESH:C029536	58994(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|evidence evidence|nmod|regulation regulation|nmod|END_ENTITY	Effect of procysteine on aging-associated changes in hepatic GSH and SMase : evidence for transcriptional regulation of smpd3 .
23629652	0	profilaggrin	70,82	Kallikrein-related_peptidase_5	0,30	profilaggrin	Kallikrein-related peptidase 5	null	25818	Chemical	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	Kallikrein-related_peptidase_5 functions in proteolytic processing of profilaggrin in cultured human keratinocytes .
6089242	0	progabide	49,58	GABA_receptor	62,75	progabide	GABA receptor	MESH:C017985	11337	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Pharmacology of the GABAergic system : effects of progabide , a GABA_receptor agonist .
12604236	0	progesterone	131,143	20alpha-hydroxysteroid_dehydrogenase	41,77	progesterone	20alpha-hydroxysteroid dehydrogenase	MESH:D011374	1645	Chemical	Gene	derived|nmod|START_ENTITY derived|nsubj|inhibitors inhibitors|nmod|END_ENTITY	Selective and potent inhibitors of human 20alpha-hydroxysteroid_dehydrogenase -LRB- AKR1C1 -RRB- that metabolizes neurosteroids derived from progesterone .
17122075	0	progesterone	70,82	20alpha-hydroxysteroid_dehydrogenase	8,44	progesterone	20alpha-hydroxysteroid dehydrogenase	MESH:D011374	105349(Tax:10090)	Chemical	Gene	catabolizes|xcomp|START_ENTITY catabolizes|nsubj|END_ENTITY	Adrenal 20alpha-hydroxysteroid_dehydrogenase in the mouse catabolizes progesterone and 11-deoxycorticosterone and is restricted to the X-zone .
2143469	0	progesterone	76,88	3_beta-hydroxysteroid_dehydrogenase	30,65	progesterone	3 beta-hydroxysteroid dehydrogenase	MESH:D011374	3283	Chemical	Gene	concentrations|compound|START_ENTITY concentrations|amod|END_ENTITY	Effects of DHA-S on placental 3_beta-hydroxysteroid_dehydrogenase activity , progesterone and 20 alpha-dihydroprogesterone concentrations in placenta and serum .
24140593	0	progesterone	17,29	ALK3	69,73	progesterone	ALK3	MESH:D011374	657	Chemical	Gene	production|amod|START_ENTITY suppresses|dobj|production suppresses|nmod|StAR StAR|nmod|END_ENTITY	BMP15 suppresses progesterone production by down-regulating StAR via ALK3 in human granulosa cells .
19081562	0	progesterone	59,71	Adiponectin	0,11	progesterone	Adiponectin	MESH:D011374	9370	Chemical	Gene	increases|dobj|START_ENTITY increases|nsubj|END_ENTITY	Adiponectin increases insulin-like_growth_factor_I-induced progesterone and estradiol secretion in human granulosa cells .
25338202	0	progesterone	23,35	Adiponectin	0,11	progesterone	Adiponectin	MESH:D011374	9370	Chemical	Gene	production|amod|START_ENTITY influences|dobj|production influences|nsubj|END_ENTITY	Adiponectin influences progesterone production from MA-10 Leydig cells in a dose-dependent manner .
1919391	0	progesterone	34,46	Avidin	0,6	progesterone	Avidin	MESH:D011374	396260(Tax:9031)	Chemical	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	Avidin and ovalbumin induction by progesterone in chicken oviduct detected by sensitive immunoenzymometric assays .
9698273	0	progesterone	29,41	Beta-endorphin	0,14	progesterone	Beta-endorphin	MESH:D011374	5443	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Beta-endorphin inhibition of progesterone secretion by porcine granulosa cells during follicle development .
11784143	0	progesterone	17,29	C-7	0,3	progesterone	C-7	MESH:D011374	730	Chemical	Gene	analogues|nmod|START_ENTITY analogues|compound|END_ENTITY	C-7 analogues of progesterone as potent inhibitors of the P-glycoprotein efflux pump .
2351224	0	progesterone	17,29	CA-125	9,15	progesterone	CA-125	MESH:D011374	94025	Chemical	Gene	protein|dep|START_ENTITY protein|compound|END_ENTITY	Relaxin , CA-125 , progesterone , estradiol , Schwangerschaft protein , and human chorionic gonadotropin as predictors of outcome in threatened and nonthreatened pregnancies .
8554564	0	progesterone	19,31	CFTR	35,39	progesterone	CFTR	MESH:D011374	100135647(Tax:10141)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Down-regulation by progesterone of CFTR expression in endometrial epithelial cells : a study by competitive RT-PCR .
16399999	0	progesterone	11,23	COX-2	33,38	progesterone	COX-2	MESH:D011374	29527(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of progesterone on iNOS , COX-2 , and collagen expression in the cervix .
20530431	0	progesterone	16,28	COX-2	66,71	progesterone	COX-2	MESH:D011374	5743	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Increased serum progesterone and estradiol_correlate to increased COX-2 tissue expression in cervical_intraepithelial_neoplasia .
21543431	0	progesterone	24,36	COX-2	40,45	progesterone	COX-2	MESH:D011374	5743	Chemical	Gene	START_ENTITY|nmod|expressions expressions|amod|END_ENTITY	Differential effects of progesterone on COX-2 and Mn-SOD expressions are associated with histone acetylation status of the promoter region in human endometrial stromal cells .
19671838	0	progesterone	19,31	CYP27A1	8,15	progesterone	CYP27A1	MESH:D011374	104086(Tax:10090)	Chemical	Gene	metabolism|amod|START_ENTITY Role|nmod|metabolism Role|nmod|END_ENTITY	Role of CYP27A1 in progesterone metabolism in vitro and in vivo .
11730320	0	progesterone	5,17	Cdc2	28,32	progesterone	Cdc2	MESH:D011374	379785(Tax:8355)	Chemical	Gene	active|amod|START_ENTITY END_ENTITY|amod|active	From progesterone to active Cdc2 in Xenopus oocytes : a puzzling signalling pathway .
22447628	0	progesterone	32,44	Chemerin	0,8	progesterone	Chemerin	MESH:D011374	5919	Chemical	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Chemerin inhibits IGF-1-induced progesterone and estradiol secretion in human granulosa cells .
22447628	0	progesterone	32,44	Chemerin	0,8	progesterone	Chemerin	MESH:D011374	5919	Chemical	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Chemerin inhibits IGF-1-induced progesterone and estradiol secretion in human granulosa cells .
17170093	0	progesterone	41,53	Corticotropin-releasing_hormone	0,31	progesterone	Corticotropin-releasing hormone	MESH:D011374	1392	Chemical	Gene	production|amod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Corticotropin-releasing_hormone inhibits progesterone production in cultured human placental trophoblasts .
19665469	0	progesterone	89,101	Cxcl12	54,60	progesterone	Cxcl12	MESH:D011374	24772(Tax:10116)	Chemical	Gene	repressed|nmod|START_ENTITY repressed|nsubj|factor-1 factor-1|appos|END_ENTITY	Estrogen-induced stromal cell-derived factor-1 -LRB- SDF-1 / Cxcl12 -RRB- expression is repressed by progesterone and by Selective Estrogen Receptor Modulators via estrogen receptor alpha in rat uterine cells and tissues .
3708054	0	progesterone	109,121	Decidual_prolactin	0,18	progesterone	Decidual prolactin	MESH:D011374	5617	Chemical	Gene	treatment|compound|START_ENTITY effects|nmod|treatment production|dep|effects production|compound|END_ENTITY	Decidual_prolactin production by organ cultures of human endometrium : effects of continuous and intermittent progesterone treatment .
25244916	0	progesterone	19,31	Decorin	0,7	progesterone	Decorin	MESH:D011374	1634	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Decorin induced by progesterone plays a crucial role in suppressing endometriosis .
16123073	0	progesterone	42,54	Depp	16,20	progesterone	Depp	MESH:D011374	11067	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl:relcl|induced	A novel protein Depp , which is induced by progesterone in human endometrial stromal cells activates Elk-1 transcription factor .
16449346	0	progesterone	59,71	Dickkopf-1	0,10	progesterone	Dickkopf-1	MESH:D011374	22943	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Dickkopf-1 , an inhibitor of Wnt signaling , is regulated by progesterone in human endometrial stromal cells .
1425445	0	progesterone	169,181	Endothelin-1	0,12	progesterone	Endothelin-1	MESH:D011374	24323(Tax:10116)	Chemical	Gene	formation|amod|START_ENTITY affecting|dobj|formation steps|acl|affecting modulation|nmod|steps accumulation|nmod|modulation inhibition|nmod|accumulation END_ENTITY|dep|inhibition	Endothelin-1 as a luteinization inhibitor : inhibition of rat granulosa cell progesterone accumulation via selective modulation of key steroidogenic steps affecting both progesterone formation and degradation .
1425445	0	progesterone	76,88	Endothelin-1	0,12	progesterone	Endothelin-1	MESH:D011374	24323(Tax:10116)	Chemical	Gene	accumulation|compound|START_ENTITY inhibition|nmod|accumulation END_ENTITY|dep|inhibition	Endothelin-1 as a luteinization inhibitor : inhibition of rat granulosa cell progesterone accumulation via selective modulation of key steroidogenic steps affecting both progesterone formation and degradation .
9806262	0	progesterone	73,85	Endothelin-1	0,12	progesterone	Endothelin-1	MESH:D011374	1906	Chemical	Gene	production|compound|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Endothelin-1 inhibits basal and human chorionic gonadotrophin-stimulated progesterone production .
6968677	0	progesterone	49,61	Epidermal_growth_factor	0,23	progesterone	Epidermal growth factor	MESH:D011374	1950	Chemical	Gene	production|nmod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Epidermal_growth_factor stimulates production of progesterone in cultured human choriocarcinoma cells .
16445913	7	progesterone	1001,1013	GFAP	1025,1029	progesterone	AQP4	MESH:D011374	25293(Tax:10116)	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|expression expression|compound|END_ENTITY	Also progesterone effects on GFAP expression varied according to brain region .
21141602	0	progesterone	11,23	GLUT	45,49	progesterone	GLUT	MESH:D011374	24398(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of progesterone on the expression of GLUT in the brain following hypoxic-ischemia in newborn rats -RSB- .
23307114	2	progesterone	298,310	GLUT1	344,349	progesterone	GLUT3	MESH:D011374	25551(Tax:10116)	Chemical	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	The current study was designed to investigate the effects of progesterone on glucose transporter proteins -LRB- GLUT1 and GLUT3 -RRB- during hypoxic-ischemic_injury in a neonatal rat model .
22380541	0	progesterone	47,59	Glucocorticoid_receptor	0,23	progesterone	Glucocorticoid receptor	MESH:D011374	2908	Chemical	Gene	effect|nmod|START_ENTITY mediates|dobj|effect mediates|nsubj|END_ENTITY	Glucocorticoid_receptor mediates the effect of progesterone on uterine natural killer cells .
10718907	0	progesterone	32,44	GnRH	110,114	progesterone	GnRH	MESH:D011374	2796	Chemical	Gene	action|nmod|START_ENTITY associated|nsubjpass|action associated|nmod|changes changes|nmod|expression expression|amod|END_ENTITY	The negative feedback action of progesterone on luteinizing hormone release is not associated with changes in GnRH mRNA expression in the Ewe .
16857887	0	progesterone	25,37	GnRH	93,97	progesterone	GnRH	MESH:D011374	2796	Chemical	Gene	estradiol|acl|START_ENTITY Addition|nmod|estradiol Addition|acl|stimulated stimulated|nmod|antagonist/rFSH antagonist/rFSH|compound|END_ENTITY	Addition of estradiol to progesterone for luteal supplementation in patients stimulated with GnRH antagonist/rFSH for IVF : a randomized controlled trial .
18001329	0	progesterone	103,115	GnRH	189,193	progesterone	GnRH	MESH:D011374	25194(Tax:10116)	Chemical	Gene	rat|nmod|START_ENTITY surge|nmod|rat Facilitation|nmod|surge Facilitation|dep|effects effects|appos|END_ENTITY	Facilitation or inhibition of the oestradiol-induced gonadotrophin surge in the immature female rat by progesterone : effects on pituitary responsiveness to gonadotrophin-releasing_hormone -LRB- GnRH -RRB- , GnRH self-priming and pituitary mRNAs for the progesterone_receptor A and B isoforms .
21133851	0	progesterone	55,67	GnRH	18,22	progesterone	GnRH	MESH:D011374	2796	Chemical	Gene	case|nmod|START_ENTITY antagonists|nmod|case antagonists|amod|END_ENTITY	Administration of GnRH antagonists in case of elevated progesterone at initiation of the cycle : a prospective cohort study .
21657997	0	progesterone	55,67	GnRH	103,107	progesterone	GnRH	MESH:D011374	2796	Chemical	Gene	elevation|amod|START_ENTITY elevation|nmod|patients patients|acl|treated treated|nmod|antagonists antagonists|compound|END_ENTITY	Significantly lower pregnancy rates in the presence of progesterone elevation in patients treated with GnRH antagonists and gonadotrophins : a systematic review and meta-analysis .
21774931	0	progesterone	71,83	GnRH	127,131	progesterone	GnRH	MESH:D011374	2796	Chemical	Gene	levels|compound|START_ENTITY absence|nmod|levels hormone|nmod|absence rise|nmod|hormone detrimental|nsubj|rise detrimental|nmod|outcome outcome|nmod|cycles cycles|compound|END_ENTITY	Is a premature rise in luteinizing hormone in the absence of increased progesterone levels detrimental to pregnancy outcome in GnRH antagonist in_vitro_fertilization cycles .
21853250	0	progesterone	9,21	GnRH	25,29	progesterone	GnRH	MESH:D011374	2796	Chemical	Gene	START_ENTITY|nmod|agonist agonist|compound|END_ENTITY	Elevated progesterone in GnRH agonist down regulated in vitro fertilisation -LRB- IVFICSI -RRB- cycles reduces live birth rates but not embryo quality .
23802563	0	progesterone	92,104	GnRH	0,4	progesterone	GnRH	MESH:D011374	2796	Chemical	Gene	levels|amod|START_ENTITY role|nmod|levels agonist|dep|role agonist|compound|END_ENTITY	GnRH agonist versus GnRH antagonist in ovarian stimulation : the role of elevated peak serum progesterone levels .
6297204	0	progesterone	88,100	GnRH	43,47	progesterone	GnRH	MESH:D011374	25194(Tax:10116)	Chemical	Gene	accumulation|nmod|START_ENTITY agonists|nmod|accumulation agonists|nsubj|Effect Effect|nmod|gonadotrophin-releasing_hormone gonadotrophin-releasing_hormone|appos|END_ENTITY	Effect of gonadotrophin-releasing_hormone -LRB- GnRH -RRB- and GnRH agonists upon accumulation of progesterone , cAMP and prostaglandin in isolated preovulatory rat follicles .
8730652	0	progesterone	79,91	GnRH	29,33	progesterone	GnRH	MESH:D011374	25194(Tax:10116)	Chemical	Gene	neurons|nmod|START_ENTITY neurons|nsubj|Induction Induction|nmod|mRNA mRNA|nmod|END_ENTITY	Induction of galanin mRNA in GnRH neurons by estradiol and its facilitation by progesterone .
9014843	0	progesterone	122,134	GnRH_receptor	17,30	progesterone	GnRH receptor	MESH:D011374	443413(Tax:9940)	Chemical	Gene	effect|nmod|START_ENTITY Concentration|dep|effect Concentration|nmod|mRNA mRNA|compound|END_ENTITY	Concentration of GnRH_receptor and GnRH_receptor mRNA in pituitary tissue of orchidectomized sheep : effect of oestradiol , progesterone , and progesterone withdrawal .
9861165	0	progesterone	53,65	GnRH_receptor	20,33	progesterone	GnRH receptor	MESH:D011374	2798	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of ovine GnRH_receptor gene expression by progesterone and oestradiol .
10944203	0	progesterone	43,55	Growth_differentiation_factor-9	0,31	progesterone	Growth differentiation factor-9	MESH:D011374	14566(Tax:10090)	Chemical	Gene	synthesis|amod|START_ENTITY stimulates|dobj|synthesis stimulates|nsubj|END_ENTITY	Growth_differentiation_factor-9 stimulates progesterone synthesis in granulosa cells via a prostaglandin_E2 / EP2_receptor pathway .
19459040	0	progesterone	12,24	HCG	44,47	progesterone	HCG	MESH:D011374	3342	Chemical	Gene	rise|nsubj|START_ENTITY rise|nmod|day day|nmod|rate rate|compound|END_ENTITY	Does subtle progesterone rise on the day of HCG affect pregnancy rate in long agonist ICSI cycles ?
6771092	0	progesterone	66,78	HCG	10,13	progesterone	HCG	MESH:D011374	3342	Chemical	Gene	systems|amod|START_ENTITY intrauterine|dobj|systems intrauterine|nsubj|Levels Levels|nmod|END_ENTITY	Levels of HCG in subjects using the Progestasert -LRB- TM -RRB- intrauterine progesterone systems .
19239424	0	progesterone	10,22	HLA-E	26,31	progesterone	HLA-E	MESH:D011374	3133	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of progesterone on HLA-E gene expression in JEG-3 choriocarcinoma cell line .
16684846	0	progesterone	61,73	HLA-G	23,28	progesterone	HLA-G	MESH:D011374	3135	Chemical	Gene	element|amod|START_ENTITY regulates|nmod|element regulates|dobj|expression expression|amod|END_ENTITY	Progesterone regulates HLA-G gene expression through a novel progesterone response element .
19527229	0	progesterone	36,48	HLA-G	0,5	progesterone	HLA-G	MESH:D011374	3135	Chemical	Gene	up-regulated|nmod|START_ENTITY up-regulated|nsubjpass|expression expression|amod|END_ENTITY	HLA-G expression is up-regulated by progesterone in mesenchymal stem cells .
21330545	0	progesterone	32,44	Hand2	82,87	progesterone	Hand2	MESH:D011374	15111(Tax:10090)	Chemical	Gene	action|nmod|START_ENTITY mediated|nsubjpass|action mediated|nmod|END_ENTITY	The antiproliferative action of progesterone in uterine epithelium is mediated by Hand2 .
18250406	0	progesterone	14,26	IFN-alpha	37,46	progesterone	IFN-alpha	MESH:D011374	3439	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|amod|END_ENTITY	Cutting edge : progesterone regulates IFN-alpha production by plasmacytoid dendritic cells .
8889839	0	progesterone	11,23	IGF-1	43,48	progesterone	IGF-1	MESH:D011374	24482(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|nmod|END_ENTITY	Effects of progesterone on serum levels of IGF-1 and on femur IGF-1 mRNA in ovariectomized rats .
8344216	9	progesterone	2061,2073	IGF-II	2037,2043	progesterone	IGF-II	MESH:D011374	396916(Tax:9823)	Chemical	Gene	accumulation|amod|START_ENTITY stimulation|nmod|accumulation stimulation|nmod:poss|END_ENTITY	Cotreatment with FSH or E2 for 4 days decreased the ED50 of IGF-II 's stimulation of progesterone accumulation by 61 % and 50 % , respectively -LRB- P < 0.01 -RRB- .
8690108	0	progesterone	56,68	IGF-II	39,45	progesterone	IGF-II	MESH:D011374	3481	Chemical	Gene	production|compound|START_ENTITY production|amod|END_ENTITY	Insulin-like_growth_factor _ -LRB- IGF -RRB- - I and IGF-II stimulate progesterone production by human luteal cells : role of IGF-I as mediator of growth_hormone action .
9387786	0	progesterone	21,33	IGF-II	11,17	progesterone	IGF-II	MESH:D011374	24483(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	-LSB- Effect of IGF-II on progesterone production by cultured rat luteal cells in vitro -RSB- .
24120276	0	progesterone	19,31	Insulin	0,7	progesterone	Insulin	MESH:D011374	3630	Chemical	Gene	secretion|amod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Insulin stimulates progesterone secretion to a greater extent than LH in early pregnant buffalo luteal cells cultured in vitro .
6093547	0	progesterone	46,58	Insulin	0,7	progesterone	Insulin	MESH:D011374	3630	Chemical	Gene	cells|dep|START_ENTITY cells|amod|granulosa granulosa|nmod:npmod|stimulates stimulates|nummod|END_ENTITY	Insulin stimulates granulosa cells : increased progesterone and cAMP production in vitro .
2378930	0	progesterone	37,49	Interleukin-1_alpha	0,19	progesterone	Interleukin-1 alpha	MESH:D011374	3552	Chemical	Gene	production|compound|START_ENTITY increases|dobj|production increases|nsubj|END_ENTITY	Interleukin-1_alpha increases thecal progesterone production of preovulatory follicles in cyclic hamsters .
7740171	0	progesterone	66,78	Interleukin-1_alpha	0,19	progesterone	Interleukin-1 alpha	MESH:D011374	3552	Chemical	Gene	START_ENTITY|nsubj|inhibition inhibition|amod|END_ENTITY	Interleukin-1_alpha inhibition of luteinized human granulosa cell progesterone production through influences on associated white blood cells .
12788874	0	progesterone	30,42	Interleukin-1_beta	0,18	progesterone	Interleukin-1 beta	MESH:D011374	3553	Chemical	Gene	production|amod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Interleukin-1_beta stimulates progesterone production by in vitro human luteal cells : evidence of a mediatory role of prostaglandins .
8641202	0	progesterone	130,142	Interleukin-1_beta	0,18	progesterone	Interleukin-1 beta	MESH:D011374	3553	Chemical	Gene	biosynthesis|compound|START_ENTITY ceramide|nmod|biosynthesis role|nmod|ceramide evidence|nmod|role hydrolysis|dep|evidence hydrolysis|amod|END_ENTITY	Interleukin-1_beta stimulates sphingomyelin hydrolysis in cultured granulosa cells : evidence for a regulatory role of ceramide on progesterone and prostaglandin biosynthesis .
9359471	0	progesterone	28,40	Interleukin-1_beta	0,18	progesterone	Interleukin-1 beta	MESH:D011374	24494(Tax:10116)	Chemical	Gene	accumulation|amod|START_ENTITY inhibits|dobj|accumulation inhibits|dep|END_ENTITY	Interleukin-1_beta inhibits progesterone accumulation in rat corpora luteal cell cultures in a mechanism dissociated from its effects on nitric_oxide and prostaglandin_E accumulation .
9405973	0	progesterone	47,59	Interleukin-1_beta	0,18	progesterone	Interleukin-1 beta	MESH:D011374	101023446	Chemical	Gene	secretion|compound|START_ENTITY inhibits|nmod|secretion inhibits|nsubj|END_ENTITY	Interleukin-1_beta inhibits in vitro pulsatile progesterone secretion and stimulates prostaglandin_F2_alpha secretion by micro-retrodialyzed baboon_corpus_luteum .
15780010	0	progesterone	28,40	Interleukin-8	0,13	progesterone	Interleukin-8	MESH:D011374	3576	Chemical	Gene	secretion|amod|START_ENTITY stimulate|dobj|secretion stimulate|nsubj|END_ENTITY	Interleukin-8 can stimulate progesterone secretion from a human trophoblast cell line , BeWo .
23160800	0	progesterone	25,37	Interleukin-8	0,13	progesterone	Interleukin-8	MESH:D011374	280828(Tax:9913)	Chemical	Gene	production|amod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Interleukin-8 stimulates progesterone production via the MEK pathway in ovarian theca cells .
10979034	0	progesterone	20,32	LHRH	0,4	progesterone	LHRH	MESH:D011374	2796	Chemical	Gene	secretion|amod|START_ENTITY modulator|nmod|secretion END_ENTITY|dep|modulator	LHRH - modulator of progesterone and estradiol secretion by theca and granulosa cells on porcine follicle in mono - and co-culture .
1100290	0	progesterone	14,26	LHRH	54,58	progesterone	LHRH	MESH:D011374	2796	Chemical	Gene	effect|nmod|START_ENTITY response|nsubj|effect response|xcomp|END_ENTITY	The effect of progesterone and FSH and LH response to LHRH in normal women .
2054151	0	progesterone	17,29	LHRH	11,15	progesterone	LHRH	MESH:D011374	25194(Tax:10116)	Chemical	Gene	beta|amod|START_ENTITY beta|amod|END_ENTITY	Effects of LHRH , progesterone , estradiol-17 beta and dexamethasone in vitro on pineal synaptic ribbons and serotonin_N-acetyltransferase activity in diestrous rats .
3113437	0	progesterone	84,96	LHRH	67,71	progesterone	LHRH	MESH:D011374	25194(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY stimulated|dobj|production stimulated|dep|C C|nmod|luteinizing_hormone-releasing_hormone luteinizing_hormone-releasing_hormone|appos|END_ENTITY	Role of protein kinase C in luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- - stimulated progesterone production in rat granulosa cells .
3279272	0	progesterone	20,32	LHRH	94,98	progesterone	LHRH	MESH:D011374	25194(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY surge|nsubj|role surge|nmod|modulation modulation|nmod|activity activity|compound|END_ENTITY	A possible role for progesterone in the preovulatory gonadotropin surge through modulation of LHRH degrading activity .
3887198	0	progesterone	11,23	LHRH	51,55	progesterone	LHRH	MESH:D011374	25194(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of progesterone on hypothalamic and plasma LHRH .
7032893	0	progesterone	15,27	LHRH	103,107	progesterone	LHRH	MESH:D011374	25194(Tax:10116)	Chemical	Gene	accumulation|amod|START_ENTITY accumulation|nmod|END_ENTITY	Stimulation of progesterone and prostaglandin_E accumulation by luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- and LHRH analogs in rat granulosa cells .
23409146	1	progesterone	140,152	LIF	77,80	progesterone	LIF	MESH:D011374	16878(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nmod|effect	LIF as a potential mediator of the anti-inflammatory effect of progesterone .
10357956	0	progesterone	56,68	Leptin	0,6	progesterone	Leptin	MESH:D011374	3952	Chemical	Gene	production|compound|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Leptin inhibits gonadotrophin-stimulated granulosa cell progesterone production by antagonizing insulin action .
11452227	0	progesterone	69,81	Leptin	0,6	progesterone	Leptin	MESH:D011374	25608(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY action|nmod|release modulates|dobj|action modulates|nsubj|END_ENTITY	Leptin modulates the corticotropin-releasing_hormone -LRB- CRH -RRB- action on progesterone release from cultured rat granulosa cells .
16987633	0	progesterone	70,82	Leptin	0,6	progesterone	Leptin	MESH:D011374	3952	Chemical	Gene	production|amod|START_ENTITY affect|dobj|production affect|nsubj|infusion infusion|compound|END_ENTITY	Leptin infusion during the early luteal phase in ewes does not affect progesterone production .
17154301	0	progesterone	71,83	Leptin	0,6	progesterone	Leptin	MESH:D011374	280836(Tax:9913)	Chemical	Gene	production|amod|START_ENTITY expression|nmod|production END_ENTITY|dep|expression	Leptin in the bovine corpus luteum : receptor expression and effects on progesterone production .
9344869	0	progesterone	91,103	MCP-1	81,86	progesterone	MCP-1	MESH:D011374	6347	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	The inhibition of synthesis of a beta-chemokine , monocyte_chemotactic_protein-1 -LRB- MCP-1 -RRB- by progesterone .
21038694	0	progesterone	11,23	MMP-3	27,32	progesterone	MMP-3	MESH:D011374	171045(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	-LSB- Effect of progesterone on MMP-3 expression in neonatal rat brain after hypoxic-ischemia -RSB- .
16600042	0	progesterone	108,120	MMP2	64,68	progesterone	MMP2	MESH:D011374	4313	Chemical	Gene	elements|compound|START_ENTITY independent|nmod|elements transcription|xcomp|independent transcription|nsubj|mechanism mechanism|nmod|regulation regulation|nmod|END_ENTITY	A proposed mechanism for progesterone regulation of trophoblast MMP2 transcription independent of classical progesterone response elements on its promoter .
16600042	0	progesterone	25,37	MMP2	64,68	progesterone	MMP2	MESH:D011374	4313	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	A proposed mechanism for progesterone regulation of trophoblast MMP2 transcription independent of classical progesterone response elements on its promoter .
17678863	6	progesterone	704,716	MMP2	727,731	progesterone	MMP2	MESH:D011374	4313	Chemical	Gene	decreased|nsubj|START_ENTITY decreased|dobj|expression expression|compound|END_ENTITY	RESULTS : In decidua with overexpressed PRB , progesterone decreased MMP2 expression .
2944912	0	progesterone	63,75	Met-enkephalin	0,14	progesterone	Met-enkephalin	MESH:D011374	5443	Chemical	Gene	production|compound|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	Met-enkephalin enhances follicle-stimulating hormone-dependent progesterone production from cultured granulosa cells .
20383792	0	progesterone	90,102	Microsomal_epoxide_hydrolase	0,28	progesterone	Microsomal epoxide hydrolase	MESH:D011374	2052	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	Microsomal_epoxide_hydrolase expression in the endometrial uterine corpus is regulated by progesterone during the menstrual cycle .
10809083	0	progesterone	5,17	Milk	0,4	progesterone	Milk	MESH:D011374	100532204	Chemical	Gene	profiles|compound|START_ENTITY profiles|compound|END_ENTITY	Milk progesterone profiles in various reproductive states in dairy buffaloes under field conditions .
16725820	0	progesterone	5,17	Milk	0,4	progesterone	Milk	MESH:D011374	100532204	Chemical	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Milk progesterone levels in crossbred buffaloes -LRB- swamp x murrah -RRB- and a comparison to the original breeds .
17459743	0	progesterone	63,75	Neuregulin_1	0,12	progesterone	Neuregulin 1	MESH:D011374	112400(Tax:10116)	Chemical	Gene	regulated|nmod|START_ENTITY cytokine|acl:relcl|regulated cytokine|nsubj|END_ENTITY	Neuregulin_1 is a pronociceptive cytokine that is regulated by progesterone in the spinal cord : implications for sex specific pain modulation .
17409375	0	progesterone	9,21	Nr5a2	36,41	progesterone	Nr5a2	MESH:D011374	26424(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|production production|nmod|END_ENTITY	Impaired progesterone production in Nr5a2 + / - mice leads to a reduction in female reproductive function .
12206876	0	progesterone	108,120	Oxytocin	0,8	progesterone	Oxytocin	MESH:D011374	100152272(Tax:9823)	Chemical	Gene	presence|nmod|START_ENTITY swine|nmod|presence cells|nmod|swine stimulates|nmod|cells stimulates|nsubj|END_ENTITY	Oxytocin stimulates secretion of prostaglandin_F -LRB- 2alpha -RRB- from endometrial cells of swine in the presence of progesterone .
16769107	0	progesterone	68,80	Oxytocin	0,8	progesterone	Oxytocin	MESH:D011374	5020	Chemical	Gene	secretion|amod|START_ENTITY dilation|nmod|secretion effects|nmod|dilation contribute|nmod|effects contribute|nsubj|END_ENTITY	Oxytocin does not contribute to the effects of cervical dilation on progesterone secretion and embryonic development in mares .
8651597	0	progesterone	11,23	PGR	34,37	progesterone	PGR	MESH:D011374	5241	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	MCF-7 cell progesterone receptor -LRB- PGR -RRB- is additionally modulated by sex_steroid_binding_protein -LRB- SBP -RRB- and its membrane receptor -LRB- SBP-R -RRB- through cAMP and PKA .
22650023	0	progesterone	46,58	PP2A	1,5	progesterone	PP2A	MESH:D011374	19052(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY involved|nmod|effect involved|nsubjpass|END_ENTITY	-LSB- PP2A is involved in the inhibitory effect of progesterone on proliferation of mouse endometrial epithelial cells -RSB- .
20133449	0	progesterone	40,52	PPAR-gamma_coactivator-1alpha	0,29	progesterone	PPAR-gamma coactivator-1alpha	MESH:D011374	83516(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	PPAR-gamma_coactivator-1alpha regulates progesterone production in ovarian granulosa cells with SF-1 and LRH-1 .
19696010	0	progesterone	107,119	PTGS2	18,23	progesterone	PTGS2	MESH:D011374	5743	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|dep|effects	HSD11B1 , HSD11B2 , PTGS2 , and NR3C1 expression in the peri-implantation ovine uterus : effects of pregnancy , progesterone , and interferon tau .
10859261	0	progesterone	64,76	Pituitary_adenylate_cyclase-activating_peptide	0,46	progesterone	Pituitary adenylate cyclase-activating peptide	MESH:D011374	24166(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Pituitary_adenylate_cyclase-activating_peptide stimulates acute progesterone production in rat granulosa/Lutein cells via two receptor subtypes .
6370734	0	progesterone	61,73	Placental_protein_12	0,20	progesterone	Placental protein 12	MESH:D011374	3484	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Placental_protein_12 -LRB- PP12 -RRB- is induced in the endometrium by progesterone .
12516630	0	progesterone	53,65	Progesterone_induced_blocking_factor	0,36	progesterone	Progesterone induced blocking factor	MESH:D011374	10464	Chemical	Gene	suppression|amod|START_ENTITY mediates|dobj|suppression mediates|nsubj|END_ENTITY	Progesterone_induced_blocking_factor -LRB- PIBF -RRB- mediates progesterone induced suppression of decidual lymphocyte cytotoxicity .
10577832	0	progesterone	42,54	Progesterone_receptor	0,21	progesterone	Progesterone receptor	MESH:D011374	25154(Tax:10116)	Chemical	Gene	action|amod|START_ENTITY required|nmod|action required|nsubjpass|END_ENTITY	Progesterone_receptor is not required for progesterone action in the rat corpus luteum of pregnancy .
12009386	0	progesterone	138,150	Progesterone_receptor	0,21	progesterone	Progesterone receptor	MESH:D011374	613024(Tax:9544)	Chemical	Gene	withdrawal|amod|START_ENTITY evidence|nmod|withdrawal localization|dep|evidence localization|compound|END_ENTITY	Progesterone_receptor localization and isoforms in myometrium , decidua , and fetal membranes from rhesus_macaques : evidence for functional progesterone withdrawal at parturition .
15764807	0	progesterone	135,147	Progesterone_receptor	0,21	progesterone	Progesterone receptor	MESH:D011374	5241	Chemical	Gene	withdrawal|amod|START_ENTITY mechanism|nmod|withdrawal expression|dep|mechanism expression|amod|END_ENTITY	Progesterone_receptor expression in human decidua and fetal membranes before and after contractions : possible mechanism for functional progesterone withdrawal .
22348324	0	progesterone	99,111	Progesterone_receptor	0,21	progesterone	Progesterone receptor	MESH:D011374	5241	Chemical	Gene	response|amod|START_ENTITY binding|nmod|response element|amod|binding expression|nmod|element downregulates|dobj|expression downregulates|nsubj|END_ENTITY	Progesterone_receptor downregulates breast_cancer_resistance_protein expression via binding to the progesterone response element in breast_cancer .
25157946	0	progesterone	85,97	Progesterone_receptor	0,21	progesterone	Progesterone receptor	MESH:D011374	100724945	Chemical	Gene	withdrawal|amod|START_ENTITY uterus|nmod|withdrawal declines|nmod|uterus declines|nsubj|expression expression|amod|END_ENTITY	Progesterone_receptor expression declines in the guinea_pig uterus during functional progesterone withdrawal and in response to prostaglandins .
3698920	0	progesterone	53,65	Progesterone_receptor	0,21	progesterone	Progesterone receptor	MESH:D011374	101825493	Chemical	Gene	treatment|amod|START_ENTITY replenishment|nmod|treatment replenishment|nsubj|END_ENTITY	Progesterone_receptor replenishment during sustained progesterone treatment in the hamster uterus .
7626494	0	progesterone	53,65	Progesterone_receptor	0,21	progesterone	Progesterone receptor	MESH:D011374	5241	Chemical	Gene	antagonists|amod|START_ENTITY mechanism|nmod|antagonists mechanism|amod|END_ENTITY	Progesterone_receptor and the mechanism of action of progesterone antagonists .
7720632	0	progesterone	129,141	Progesterone_receptor	0,21	progesterone	Progesterone receptor	MESH:D011374	613024(Tax:9544)	Chemical	Gene	regulation|nmod|START_ENTITY messenger|dep|regulation messenger|amod|END_ENTITY	Progesterone_receptor messenger ribonucleic_acid in the primate corpus luteum during the menstrual cycle : possible regulation by progesterone .
2383926	0	progesterone	101,113	Prolactin	0,9	progesterone	Prolactin	MESH:D011374	5617	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|END_ENTITY	Prolactin secretion in women during the oestradiol-induced luteinizing hormone surge with or without progesterone .
2923259	0	progesterone	59,71	Prolactin	0,9	progesterone	Prolactin	MESH:D011374	24683(Tax:10116)	Chemical	Gene	absence|nmod|START_ENTITY stimulates|nmod|absence stimulates|nsubj|END_ENTITY	Prolactin stimulates food intake in the absence of ovarian progesterone .
3091106	0	progesterone	74,86	Prolactin	0,9	progesterone	Prolactin	MESH:D011374	24683(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY steroidogenesis|dobj|Effects steroidogenesis|nsubj|modulates modulates|compound|END_ENTITY	Prolactin modulates steroidogenesis by rat granulosa cells : I. Effects on progesterone .
3594432	0	progesterone	40,52	Prolactin	0,9	progesterone	Prolactin	MESH:D011374	24683(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|amod|END_ENTITY	Prolactin release-inhibitory effects of progesterone , megestrol_acetate , and mifepristone -LRB- RU_38486 -RRB- by cultured rat pituitary_tumor cells .
4090915	0	progesterone	56,68	Prolactin	0,9	progesterone	Prolactin	MESH:D011374	19109(Tax:10090)	Chemical	Gene	accumulation|amod|START_ENTITY effects|nmod|accumulation effects|compound|END_ENTITY	Prolactin effects on basal and gonadotrophin-stimulated progesterone accumulation by PMSG-primed mouse ovaries in vitro .
7076799	0	progesterone	82,94	Prolactin	0,9	progesterone	Prolactin	MESH:D011374	5617	Chemical	Gene	secretion|nmod|START_ENTITY inhibits|dobj|secretion inhibits|nsubj|END_ENTITY	Prolactin directly inhibits basal as well as gonadotropin-stimulated secretion of progesterone and 17 beta-estradiol in the human ovary .
24085821	0	progesterone	71,83	Prostate_androgen-regulated_mucin-like_protein_1	0,48	progesterone	Prostate androgen-regulated mucin-like protein 1	MESH:D011374	286894(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY regulator|nmod|metabolism END_ENTITY|dep|regulator	Prostate_androgen-regulated_mucin-like_protein_1 : a novel regulator of progesterone metabolism .
17217369	0	progesterone	66,78	RANTES	15,21	progesterone	RANTES	MESH:D011374	20304(Tax:10090)	Chemical	Gene	Implication|nmod|START_ENTITY Implication|nmod|END_ENTITY	Implication of RANTES in the modulation of alloimmune response by progesterone during pregnancy .
24140593	0	progesterone	17,29	StAR	60,64	progesterone	StAR	MESH:D011374	6770	Chemical	Gene	production|amod|START_ENTITY suppresses|dobj|production suppresses|nmod|END_ENTITY	BMP15 suppresses progesterone production by down-regulating StAR via ALK3 in human granulosa cells .
8522236	0	progesterone	58,70	TNF-alpha	15,24	progesterone	TNF-alpha	MESH:D011374	7124	Chemical	Gene	synthesis|amod|START_ENTITY -LSB-|nmod|synthesis -LSB-|dobj|effect effect|nmod|END_ENTITY	-LSB- The effect of TNF-alpha -LRB- tumor_necrosis_factor-alpha -RRB- on progesterone synthesis in vitro by cells from ovarian follicular fluid in women -RSB- .
8567961	0	progesterone	64,76	Thrombospondin-1	0,16	progesterone	Thrombospondin-1	MESH:D011374	7057	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Thrombospondin-1 , an inhibitor of angiogenesis , is regulated by progesterone in the human endometrium .
7638197	0	progesterone	45,57	Transforming_growth_factor_beta	0,31	progesterone	Transforming growth factor beta	MESH:D011374	7040	Chemical	Gene	suppression|amod|START_ENTITY mediates|dobj|suppression mediates|nsubj|END_ENTITY	Transforming_growth_factor_beta mediates the progesterone suppression of an epithelial metalloproteinase by adjacent stroma in the human endometrium .
11344239	0	progesterone	93,105	Tumor_necrosis_factor-alpha	0,27	progesterone	Tumor necrosis factor-alpha	MESH:D011374	7124	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Tumor_necrosis_factor-alpha expression in human uterine_leiomyoma and its down-regulation by progesterone .
14967894	0	progesterone	49,61	Tumor_necrosis_factor-alpha	0,27	progesterone	Tumor necrosis factor-alpha	MESH:D011374	280943(Tax:9913)	Chemical	Gene	production|amod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha -LRB- TNF_alpha -RRB- inhibits progesterone and estradiol-17beta production from cultured granulosa cells : presence of TNFalpha receptors in bovine granulosa and theca cells .
12121710	0	progesterone	21,33	VCAM-1	104,110	progesterone	VCAM-1	MESH:D011374	7412	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of estrogen , progesterone , and combination exposure on interleukin-1_beta-induced expression of VCAM-1 , ICAM-1 , PECAM , and E-selectin by human female iliac artery endothelial cells .
15026368	6	progesterone	831,843	VEGF	852,856	progesterone	VEGF	MESH:D011374	7422	Chemical	Gene	Treatment|nmod|START_ENTITY induces|nsubj|Treatment induces|xcomp|2-fold 2-fold|nsubj|mRNA mRNA|compound|END_ENTITY	Treatment with progesterone induces VEGF mRNA and protein approximately 2-fold in T47-Dco and YA cells and 3-7-fold in YB cells , suggesting that PRA inhibits PRB-dependent induction of VEGF .
16299233	9	progesterone	1256,1268	VEGF	1300,1304	progesterone	VEGF	MESH:D011374	7422	Chemical	Gene	had|nsubj|START_ENTITY had|dobj|correlation correlation|nmod|END_ENTITY	Plasma as well as local estradiol and breast tissue VEGF exhibited significant correlations , whereas progesterone had no correlation with breast VEGF .
17551930	0	progesterone	30,42	VEGF	92,96	progesterone	VEGF	MESH:D011374	7422	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|amod|END_ENTITY	Membrane-initiated effects of progesterone on calcium dependent signaling and activation of VEGF gene expression in retinal glial cells .
19340614	0	progesterone	30,42	VEGF	78,82	progesterone	VEGF	MESH:D011374	7422	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Membrane-initiated effects of progesterone on proliferation and activation of VEGF in breast_cancer cells .
26345811	0	progesterone	50,62	VEGF	17,21	progesterone	VEGF	MESH:D011374	83785(Tax:10116)	Chemical	Gene	signaling|nmod|START_ENTITY signaling|nsubj|END_ENTITY	Effect of HIF-1a / VEGF signaling pathway on plasma progesterone and ovarian prostaglandin_F2a secretion during luteal development of pseudopregnant rats .
26345811	0	progesterone	50,62	VEGF	17,21	progesterone	VEGF	MESH:D011374	83785(Tax:10116)	Chemical	Gene	signaling|nmod|START_ENTITY signaling|nsubj|END_ENTITY	Effect of HIF-1a / VEGF signaling pathway on plasma progesterone and ovarian prostaglandin_F2a secretion during luteal development of pseudopregnant rats .
12011800	0	progesterone	34,46	VIP	105,108	progesterone	VIP	MESH:D011374	117064(Tax:10116)	Chemical	Gene	accumulation|amod|START_ENTITY potentiation|nmod|accumulation stimulated|nsubj|potentiation stimulated|nmod|peptide peptide|appos|END_ENTITY	Alfa 1 adrenergic potentiation of progesterone accumulation stimulated by vasoactive intestinal peptide -LRB- VIP -RRB- and pituitary_adenylate_cyclase-activating_polypeptide _ -LRB- PACAP -RRB- in cultured rat granulosa cells .
20960159	0	progesterone	22,34	VIP	158,161	progesterone	VIP	MESH:D011374	117064(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY Effect|nmod|administration caused|nsubj|Effect caused|nmod|immunoreactivities immunoreactivities|compound|END_ENTITY	Effect of concomitant progesterone administration or the effect of removal of estrogen capsule on changes caused by long-term estrogen treatment in pituitary VIP immunoreactivities .
3512260	8	progesterone	1154,1166	VIP	1179,1182	progesterone	VIP	MESH:D011374	117064(Tax:10116)	Chemical	Gene	response|amod|START_ENTITY response|nmod|END_ENTITY	The progesterone response to VIP increased moderately between day 12 and first proestrus , and then strikingly at estrus and first diestrus .
3929235	0	progesterone	56,68	Vasoactive_intestinal_polypeptide	0,33	progesterone	Vasoactive intestinal polypeptide	MESH:D011374	100352512(Tax:9986)	Chemical	Gene	secretion|compound|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Vasoactive_intestinal_polypeptide stimulates nonovarian progesterone secretion in rabbits .
11114187	0	progesterone	27,39	XPR-1	18,23	progesterone	XPR-1	MESH:D011374	446765(Tax:8355)	Chemical	Gene	receptor|amod|START_ENTITY END_ENTITY|appos|receptor	Identification of XPR-1 , a progesterone receptor required for Xenopus oocyte activation .
19125374	0	progesterone	11,23	adenosine_deaminase	46,65	progesterone	adenosine deaminase	MESH:D011374	100	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of progesterone on total brain tissue adenosine_deaminase activity in experimental epilepsy .
3017465	0	progesterone	15,27	adrenocorticotropic_hormone	42,69	progesterone	adrenocorticotropic hormone	MESH:D011374	5443	Chemical	Gene	production|amod|START_ENTITY Stimulation|nmod|production Stimulation|nmod|END_ENTITY	Stimulation of progesterone production by adrenocorticotropic_hormone and prostaglandin_E2 in rat luteal cells .
23938178	0	progesterone	21,33	aldosterone_synthase	74,94	progesterone	aldosterone synthase	MESH:D011374	1585	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nsubj|effects	Different effects of progesterone and estradiol on chimeric and wild type aldosterone_synthase in vitro .
946146	0	progesterone	49,61	alpha-MSH	10,19	progesterone	alpha-MSH	MESH:D011374	5443	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of alpha-MSH on plasma levels of LH , FSH , progesterone and cortisol during the corpus luteum phase of the menstrual cycle .
9294849	0	progesterone	37,49	angiotensin_II	19,33	progesterone	angiotensin II	MESH:D011374	183	Chemical	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	Regulatory role of angiotensin_II on progesterone production by cultured human granulosa cells .
17446234	0	progesterone	35,47	annexin_2	78,87	progesterone	annexin 2	MESH:D011374	100048993(Tax:9940)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|induction induction|nmod|END_ENTITY	Separate and synergistic effect of progesterone and estradiol on induction of annexin_2 and its interaction protein p11 in pregnant sheep myometrium .
26638215	0	progesterone	26,38	aquaporin-4	115,126	progesterone	aquaporin-4	MESH:D011374	25293(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY Effect|nmod|administration Effect|dep|changes changes|acl|END_ENTITY	Effect of estrogen and/or progesterone administration on traumatic brain_injury-caused brain_edema : the changes of aquaporin-4 and interleukin-6 .
1472452	0	progesterone	35,47	avidin	20,26	progesterone	avidin	MESH:D011374	396260(Tax:9031)	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Inducibility of the avidin gene by progesterone is suppressed during estrogen-induced cytodifferentiation .
16303606	0	progesterone	10,22	bax	44,47	progesterone	bax	MESH:D011374	280730(Tax:9913)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	Effect of progesterone on the expression of bax and bcl-2 and on caspase activity in bovine luteal cells .
19325006	0	progesterone	47,59	brain-derived_neurotrophic_factor	124,157	progesterone	brain-derived neurotrophic factor	MESH:D011374	12064(Tax:10090)	Chemical	Gene	efficacy|nmod|START_ENTITY differences|nmod|efficacy correlate|nsubj|differences correlate|nmod|expression expression|amod|END_ENTITY	The differences in neuroprotective efficacy of progesterone and medroxyprogesterone_acetate correlate with their effects on brain-derived_neurotrophic_factor expression .
3162308	0	progesterone	54,66	c-myc	20,25	progesterone	c-myc	MESH:D011374	420332(Tax:9031)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Rapid regulation of c-myc protooncogene expression by progesterone in the avian oviduct .
9681502	0	progesterone	56,68	cadherin-11	72,83	progesterone	cadherin-11	MESH:D011374	1009	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	17Beta-estradiol potentiates the stimulatory effects of progesterone on cadherin-11 expression in cultured human endometrial stromal cells .
2033240	0	progesterone	85,97	catechol-O-methyltransferase	13,41	progesterone	catechol-O-methyltransferase	MESH:D011374	24267(Tax:10116)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of catechol-O-methyltransferase in the luminal epithelium of rat uterus by progesterone .
11452227	0	progesterone	69,81	corticotropin-releasing_hormone	21,52	progesterone	corticotropin-releasing hormone	MESH:D011374	81648(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY action|nmod|release action|amod|END_ENTITY	Leptin modulates the corticotropin-releasing_hormone -LRB- CRH -RRB- action on progesterone release from cultured rat granulosa cells .
17560576	0	progesterone	26,38	cyclin_D1	127,136	progesterone	cyclin D1	MESH:D011374	12443(Tax:10090)	Chemical	Gene	inhibition|amod|START_ENTITY mediates|nmod|inhibition mediates|nmod|localization localization|nmod|END_ENTITY	GSK-3beta mediates in the progesterone inhibition of estrogen induced cyclin_D2 nuclear localization and cell proliferation in cyclin_D1 - / - mouse uterine epithelium .
23432380	0	progesterone	33,45	cyclin_D1	74,83	progesterone	cyclin D1	MESH:D011374	595	Chemical	Gene	expression|nmod|START_ENTITY Regulation|nmod|expression Regulation|dep|effects effects|nmod|END_ENTITY	Regulation of gene expression by progesterone in cancer cells : effects on cyclin_D1 , EGFR and VEGF .
22649121	0	progesterone	12,24	cyclin_G1	45,54	progesterone	cyclin G1	MESH:D011374	900	Chemical	Gene	role|nmod|START_ENTITY role|nmod|expression expression|amod|END_ENTITY	The role of progesterone and its receptor on cyclin_G1 expression in endometrial_carcinoma cells .
16825323	0	progesterone	184,196	cyclooxygenase-2	66,82	progesterone	cyclooxygenase-2	MESH:D011374	282023(Tax:9913)	Chemical	Gene	receptor|amod|START_ENTITY regulated|nmod|receptor regulated|nsubjpass|expression expression|nmod|messenger messenger|acl|ribonucleic_acid ribonucleic_acid|nmod|END_ENTITY	Gonadotropin-induced expression of messenger ribonucleic_acid for cyclooxygenase-2 and production of prostaglandins_E_and_F2alpha in bovine preovulatory follicles are regulated by the progesterone receptor .
19837932	0	progesterone	14,26	cyclooxygenase-2	108,124	progesterone	cyclooxygenase-2	MESH:D011374	5743	Chemical	Gene	receptor|amod|START_ENTITY Expression|nmod|receptor Expression|nmod|expression expression|amod|END_ENTITY	Expression of progesterone receptor A form and its role in the interaction of progesterone with cortisol on cyclooxygenase-2 expression in amnionic fibroblasts .
3396695	0	progesterone	25,37	decidual_prolactin	51,69	progesterone	decidual prolactin	MESH:D011374	5617	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Effect of short-duration progesterone treatment on decidual_prolactin production by cultures of proliferative human endometrium .
3698908	0	progesterone	11,23	decidual_prolactin	27,45	progesterone	decidual prolactin	MESH:D011374	5617	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|production production|compound|END_ENTITY	Effects of progesterone on decidual_prolactin production by organ cultures of human endometrium .
10074248	0	progesterone	32,44	endothelin-1	12,24	progesterone	endothelin-1	MESH:D011374	24323(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	-LSB- Effects of endothelin-1 on the progesterone production of rat preovulatory ovarian granulosa cells -RSB- .
11971747	0	progesterone	70,82	endothelin-1	34,46	progesterone	endothelin-1	MESH:D011374	1906	Chemical	Gene	secretion|amod|START_ENTITY inhibition|nmod|secretion provoked|dobj|inhibition provoked|nsubj|role role|nmod|nitric_oxide nitric_oxide|nmod|END_ENTITY	Potential role of nitric_oxide in endothelin-1 provoked inhibition of progesterone secretion by isolated ovarian granulosa cells .
12949628	0	progesterone	71,83	endothelin-1	55,67	progesterone	endothelin-1	MESH:D011374	1906	Chemical	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	Involvement of prostanoids in the inhibitory effect of endothelin-1 on progesterone production of ovarian granulosa cells .
23592430	0	progesterone	47,59	endothelin-a_receptor	11,32	progesterone	endothelin-a receptor	MESH:D011374	13617(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Control of endothelin-a_receptor expression by progesterone is enhanced by synergy with Gata2 .
7507841	0	progesterone	112,124	epidermal_growth_factor_receptor	27,59	progesterone	epidermal growth factor receptor	MESH:D011374	13649(Tax:10090)	Chemical	Gene	bioactivity|nmod|START_ENTITY bioactivity|nsubj|expression expression|nmod|gene gene|amod|END_ENTITY	Differential expression of epidermal_growth_factor_receptor -LRB- EGF-R -RRB- gene and regulation of EGF-R bioactivity by progesterone and estrogen in the adult mouse uterus .
9665341	0	progesterone	148,160	epidermal_growth_factor_receptor	80,112	progesterone	epidermal growth factor receptor	MESH:D011374	1956	Chemical	Gene	influence|nmod|START_ENTITY detection|dep|influence detection|nmod|END_ENTITY	Flow cytometric detection and binding studies of human endometrial stromal cell epidermal_growth_factor_receptor in monolayer culture : influence of progesterone .
12396561	0	progesterone	170,182	estrogen_receptor	230,247	progesterone	estrogen receptor	MESH:D011374	2099	Chemical	Gene	START_ENTITY|nmod|explants explants|acl|expressing expressing|dobj|END_ENTITY	Cyproterone , norethindrone , medroxyprogesterone and levonorgestrel are less potent local human growth_hormone and insulin-like_growth_factor_I secretion stimulators than progesterone in human breast_cancer explants expressing the estrogen_receptor .
17683929	0	progesterone	62,74	estrogen_receptor	14,31	progesterone	estrogen receptor	MESH:D011374	2099	Chemical	Gene	metabolites|amod|START_ENTITY Regulation|nmod|metabolites Regulation|nmod|levels levels|amod|END_ENTITY	Regulation of estrogen_receptor -LRB- ER -RRB- levels in MCF-7 cells by progesterone metabolites .
1916218	0	progesterone	27,39	estrogen_receptor	58,75	progesterone	estrogen receptor	MESH:D011374	2099	Chemical	Gene	receptor|amod|START_ENTITY downregulates|dobj|receptor downregulates|dep|END_ENTITY	Progesterone downregulates progesterone receptor , but not estrogen_receptor , in the estrogen-primed oviduct of a turtle -LRB- Trachemys_scripta -RRB- .
2755123	0	progesterone	57,69	estrogen_receptor	97,114	progesterone	estrogen receptor	MESH:D011374	2099	Chemical	Gene	downregulation|amod|START_ENTITY downregulation|nmod|END_ENTITY	Role of porcine endometrial estrogen sulfotransferase in progesterone mediated downregulation of estrogen_receptor .
7769876	0	progesterone	23,35	estrogen_receptor	5,22	progesterone	estrogen receptor	MESH:D011374	2099	Chemical	Gene	receptor|amod|START_ENTITY receptor|dep|-LSB- -LSB-|dobj|END_ENTITY	-LSB- The estrogen_receptor / progesterone receptor quotient as an index of the transcriptional activity of estrogen_receptors in breast_cancer -RSB- .
10097091	0	progesterone	50,62	estrogen_receptor_alpha	77,100	progesterone	estrogen receptor alpha	MESH:D011374	13982(Tax:10090)	Chemical	Gene	action|amod|START_ENTITY prevent|dobj|action prevent|nmod|uterus uterus|amod|END_ENTITY	Disruption of estrogen signaling does not prevent progesterone action in the estrogen_receptor_alpha knockout mouse uterus .
17049840	0	progesterone	67,79	estrogen_receptor_alpha	36,59	progesterone	estrogen receptor alpha	MESH:D011374	2099	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Co-expression of steroid receptors -LRB- estrogen_receptor_alpha and/or progesterone receptors -RRB- and Her-2 / neu : Clinical implications .
19551522	0	progesterone	85,97	estrogen_receptor_alpha	11,34	progesterone	estrogen receptor alpha	MESH:D011374	13982(Tax:10090)	Chemical	Gene	receptors|amod|START_ENTITY induction|nmod|receptors deletion|nmod|induction deletion|compound|END_ENTITY	Effects of estrogen_receptor_alpha and beta gene deletion on estrogenic induction of progesterone receptors in the locus coeruleus in female mice .
17392499	0	progesterone	76,88	fibroblast_growth_factor_7	28,54	progesterone	fibroblast growth factor 7	MESH:D011374	397281(Tax:9823)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of expression of fibroblast_growth_factor_7 in the pig uterus by progesterone and estradiol .
15163626	0	progesterone	39,51	galectin-1	11,21	progesterone	galectin-1	MESH:D011374	414915(Tax:9823)	Chemical	Gene	production|amod|START_ENTITY regulation|nmod|production END_ENTITY|nmod|regulation	Effects of galectin-1 on regulation of progesterone production in granulosa cells from pig ovaries in vitro .
11994363	0	progesterone	206,218	gonadotropin-releasing_hormone	75,105	progesterone	gonadotropin-releasing hormone	MESH:D011374	2796	Chemical	Gene	effects|nmod|START_ENTITY loss|nmod|effects reflects|dobj|loss reflects|nsubj|increase increase|nmod|frequency frequency|amod|END_ENTITY	Hypothalamic regulation of cyclic ovulation : evidence that the increase in gonadotropin-releasing_hormone pulse frequency during the follicular phase reflects the gradual loss of the restraining effects of progesterone .
12413982	0	progesterone	14,26	gonadotropin-releasing_hormone	134,164	progesterone	gonadotropin-releasing hormone	MESH:D011374	2796	Chemical	Gene	A|amod|START_ENTITY Expression|nmod|A factor-I|nsubj|Expression factor-I|nmod|analogue analogue|amod|END_ENTITY	Expression of progesterone receptors A and B and insulin-like growth factor-I in human myometrium and fibroids after treatment with a gonadotropin-releasing_hormone analogue .
15486051	0	progesterone	113,125	gonadotropin-releasing_hormone	30,60	progesterone	gonadotropin-releasing hormone	MESH:D011374	2796	Chemical	Gene	therapy|amod|START_ENTITY receiving|dobj|therapy women|acl|receiving women|amod|END_ENTITY	Responses to a saline load in gonadotropin-releasing_hormone antagonist-pretreated premenopausal women receiving progesterone or estradiol-progesterone therapy .
17616858	0	progesterone	7,19	gonadotropin-releasing_hormone	44,74	progesterone	gonadotropin-releasing hormone	MESH:D011374	2796	Chemical	Gene	rise|nsubj|START_ENTITY rise|nmod|antagonist antagonist|amod|END_ENTITY	Subtle progesterone rise in the single-dose gonadotropin-releasing_hormone antagonist -LRB- cetrorelix -RRB- stimulation protocol in patients undergoing in_vitro_fertilization or intracytoplasmic sperm injection cycles .
19351732	0	progesterone	76,88	gonadotropin-releasing_hormone	14,44	progesterone	gonadotropin-releasing hormone	MESH:D011374	2796	Chemical	Gene	Modulation|acl|START_ENTITY Modulation|nmod|sensitivity sensitivity|amod|END_ENTITY	Modulation of gonadotropin-releasing_hormone pulse generator sensitivity to progesterone inhibition in hyperandrogenic adolescent girls -- implications for regulation of pubertal maturation .
19939363	0	progesterone	18,30	gonadotropin-releasing_hormone	113,143	progesterone	gonadotropin-releasing hormone	MESH:D011374	2796	Chemical	Gene	gel|amod|START_ENTITY efficiency|nmod|gel progesterone|nsubj|efficiency progesterone|nmod|cycles cycles|amod|END_ENTITY	The efficiency of progesterone vaginal gel versus intramuscular progesterone for luteal phase supplementation in gonadotropin-releasing_hormone antagonist cycles : a prospective clinical trial .
19939363	0	progesterone	64,76	gonadotropin-releasing_hormone	113,143	progesterone	gonadotropin-releasing hormone	MESH:D011374	2796	Chemical	Gene	START_ENTITY|nmod|cycles cycles|amod|END_ENTITY	The efficiency of progesterone vaginal gel versus intramuscular progesterone for luteal phase supplementation in gonadotropin-releasing_hormone antagonist cycles : a prospective clinical trial .
2110408	0	progesterone	55,67	gonadotropin-releasing_hormone	13,43	progesterone	gonadotropin-releasing hormone	MESH:D011374	2796	Chemical	Gene	formation|amod|START_ENTITY agonist|nmod|formation agonist|amod|END_ENTITY	Effects of a gonadotropin-releasing_hormone agonist on progesterone formation in cultured human granulosa cells .
22377800	0	progesterone	83,95	gonadotropin-releasing_hormone	39,69	progesterone	gonadotropin-releasing hormone	MESH:D011374	2796	Chemical	Gene	sensitivity|acl|START_ENTITY sensitivity|nmod|secretion secretion|amod|END_ENTITY	Differential sleep-wake sensitivity of gonadotropin-releasing_hormone secretion to progesterone inhibition in early pubertal girls .
3546570	0	progesterone	201,213	gonadotropin-releasing_hormone	32,62	progesterone	gonadotropin-releasing hormone	MESH:D011374	2796	Chemical	Gene	levels|nmod|START_ENTITY maintained|dobj|levels maintained|nsubj|Effect Effect|nmod|infusion infusion|nmod|concentrations concentrations|amod|END_ENTITY	Effect of pulsatile infusion of gonadotropin-releasing_hormone on plasma oestradiol-17 beta concentrations and follicular development during naturally and artificially maintained high levels of plasma progesterone in heifers .
3919050	0	progesterone	187,199	gonadotropin-releasing_hormone	128,158	progesterone	gonadotropin-releasing hormone	MESH:D011374	2796	Chemical	Gene	antagonism|nmod|START_ENTITY Reduction|dep|antagonism Reduction|nmod|release release|nmod|estrogen estrogen|nmod|administration administration|nmod|END_ENTITY	Reduction in pituitary desensitization and prolongation of gonadotropin release by estrogen during continuous administration of gonadotropin-releasing_hormone in women : its antagonism by progesterone .
7035139	0	progesterone	74,86	gonadotropin-releasing_hormone	15,45	progesterone	gonadotropin-releasing hormone	MESH:D011374	2796	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|agonist agonist|amod|END_ENTITY	Interaction of gonadotropin-releasing_hormone agonist and antagonist with progesterone , prolactin , or human chorionic gonadotropin during pregnancy in the rat .
7731981	0	progesterone	2,14	gonadotropin-releasing_hormone	52,82	progesterone	gonadotropin-releasing hormone	MESH:D011374	2796	Chemical	Gene	metabolite|amod|START_ENTITY stimulates|nsubj|metabolite stimulates|dobj|release release|nmod|receptor receptor|amod|END_ENTITY	A progesterone metabolite stimulates the release of gonadotropin-releasing_hormone from GT1-1 hypothalamic neurons via the gamma-aminobutyric_acid type A receptor .
7962266	0	progesterone	116,128	gonadotropin-releasing_hormone	53,83	progesterone	gonadotropin-releasing hormone	MESH:D011374	2796	Chemical	Gene	secretion|compound|START_ENTITY associated|nmod|secretion associated|nsubjpass|Induction Induction|nmod|maturation maturation|nmod|complex complex|nmod|analog analog|amod|END_ENTITY	Induction of maturation of cumulus-oocyte complex by gonadotropin-releasing_hormone analog is associated with lower progesterone secretion .
8492012	0	progesterone	65,77	gonadotropin-releasing_hormone	139,169	progesterone	gonadotropin-releasing hormone	MESH:D011374	2796	Chemical	Gene	START_ENTITY|nmod|phase phase|acl|stimulated stimulated|nmod|combination combination|nmod|analog analog|amod|END_ENTITY	-LSB- Relation between the outcome of IVF-ET and subtle rise in serum progesterone during the follicular phase stimulated with a combination of gonadotropin-releasing_hormone analog and gonadotropin -RSB- .
8636350	0	progesterone	8,20	gonadotropin-releasing_hormone	68,98	progesterone	gonadotropin-releasing hormone	MESH:D011374	2796	Chemical	Gene	factors|amod|START_ENTITY factors|acl|regulating regulating|dobj|self-priming self-priming|amod|END_ENTITY	Role of progesterone and nonsteroidal ovarian factors in regulating gonadotropin-releasing_hormone self-priming in vitro .
9531875	0	progesterone	71,83	gonadotropin-releasing_hormone	183,213	progesterone	gonadotropin-releasing hormone	MESH:D011374	2796	Chemical	Gene	concentrations|amod|START_ENTITY effect|nmod|concentrations effect|nmod|women women|acl|treated treated|nmod|agonist agonist|amod|END_ENTITY	Luteinizing hormone increases estradiol secretion but has no effect on progesterone concentrations in the late follicular phase of in vitro fertilization cycles in women treated with gonadotropin-releasing_hormone agonist and follicle-stimulating hormone .
9724815	0	progesterone	33,45	gonadotropin-releasing_hormone	49,79	progesterone	gonadotropin-releasing hormone	MESH:D011374	2796	Chemical	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	The negative feedback actions of progesterone on gonadotropin-releasing_hormone secretion are transduced by the classical progesterone_receptor .
11455330	0	progesterone	78,90	growth_hormone	11,25	progesterone	growth hormone	MESH:D011374	81668(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY Effects|nmod|release Effects|nmod|END_ENTITY	Effects of growth_hormone -LRB- GH -RRB- and growth_hormone_releasing_hormone -LRB- GHRH -RRB- on progesterone and estradiol release from cultured rat granulosa cells .
17953960	0	progesterone	62,74	growth_hormone	11,25	progesterone	growth hormone	MESH:D011374	2688	Chemical	Gene	production|amod|START_ENTITY Effects|nmod|production Effects|nmod|END_ENTITY	Effects of growth_hormone and insulin-like_growth_factor_1 on progesterone production in human luteinized granulosa cells .
12182445	0	progesterone	81,93	hCG	54,57	progesterone	hCG	MESH:D011374	3342	Chemical	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	Effect of in vivo GnRH agonist and GnRH antagonist on hCG and insulin-stimulated progesterone production by human granulosa-lutein cells in vitro .
1349590	0	progesterone	19,31	hCG	54,57	progesterone	hCG	MESH:D011374	3342	Chemical	Gene	START_ENTITY|nmod|time time|nmod|END_ENTITY	Influence of serum progesterone levels at the time of hCG on the release of ova during hMG cycles .
16726235	0	progesterone	87,99	hCG	69,72	progesterone	hCG	MESH:D011374	93659	Chemical	Gene	secretion|amod|START_ENTITY stimulate|dobj|secretion treated|xcomp|stimulate treated|nmod|gonadotropin gonadotropin|appos|END_ENTITY	Fertility of dairy cattle treated with human chorionic gonadotropin -LRB- hCG -RRB- to stimulate progesterone secretion .
19032425	0	progesterone	36,48	hCG	10,13	progesterone	hCG	MESH:D011374	93659	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of hCG on early luteal serum progesterone concentrations in PG600-treated gilts .
21801119	0	progesterone	26,38	hCG	67,70	progesterone	hCG	MESH:D011374	3342	Chemical	Gene	START_ENTITY|dobj|values values|nmod|day day|nmod|administration administration|compound|END_ENTITY	Prognostic value of serum progesterone and LH values on the day of hCG administration in IUI GnRH antagonist cycles .
22528535	0	progesterone	93,105	hCG	38,41	progesterone	hCG	MESH:D011374	93659	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|administration administration|nmod|END_ENTITY	Effects of repeated administration of hCG on follicular and luteal characteristics and serum progesterone concentrations in eCG-superovulated Sanjabi ewes .
2389060	0	progesterone	19,31	hCG	102,105	progesterone	hCG	MESH:D011374	3342	Chemical	Gene	oxytocin_and_prostaglandin|amod|START_ENTITY oxytocin_and_prostaglandin|nmod|cattle cattle|acl|treated treated|nmod|END_ENTITY	Associations among progesterone , estradiol-17_beta , _ oxytocin_and_prostaglandin in cattle treated with hCG during diestrus to extend corpus luteum function .
24012150	0	progesterone	50,62	hCG	77,80	progesterone	hCG	MESH:D011374	3342	Chemical	Gene	associated|nmod|START_ENTITY associated|nmod|day day|nmod|administration administration|compound|END_ENTITY	Recurrent IVF_failure is associated with elevated progesterone on the day of hCG administration .
24012449	0	progesterone	87,99	hCG	113,116	progesterone	hCG	MESH:D011374	3342	Chemical	Gene	elevation|amod|START_ENTITY effect|nmod|elevation overcome|dobj|effect overcome|nmod|END_ENTITY	Fresh blastocyst transfer as a clinical approach to overcome the detrimental effect of progesterone elevation at hCG triggering : a strategy in the context of the Italian law .
24549270	0	progesterone	52,64	hCG	89,92	progesterone	hCG	MESH:D011374	3342	Chemical	Gene	elevation|amod|START_ENTITY determinant|nmod|elevation level|nmod|determinant progesterone|dobj|level progesterone|nmod|day day|nmod|END_ENTITY	Basal progesterone level as the main determinant of progesterone elevation on the day of hCG triggering in controlled ovarian stimulation cycles .
24549270	0	progesterone	6,18	hCG	89,92	progesterone	hCG	MESH:D011374	3342	Chemical	Gene	START_ENTITY|nmod|day day|nmod|END_ENTITY	Basal progesterone level as the main determinant of progesterone elevation on the day of hCG triggering in controlled ovarian stimulation cycles .
25861798	0	progesterone	20,32	hCG	0,3	progesterone	hCG	MESH:D011374	3342	Chemical	Gene	increases|dobj|START_ENTITY increases|nsubj|END_ENTITY	hCG increases serum progesterone , number of corpora lutea , and angiogenic factors in pregnant sheep .
26309611	0	progesterone	27,39	hCG	22,25	progesterone	hCG	MESH:D011374	3342	Chemical	Gene	START_ENTITY|nsubj|value value|nmod|ratio ratio|nmod|END_ENTITY	The value of ratio of hCG , progesterone in local blood of pregnancy location versus venous blood in the diagnosis of ectopic pregnancy .
2788776	6	progesterone	824,836	hCG	808,811	progesterone	hCG	MESH:D011374	93659	Chemical	Gene	estradiol|amod|START_ENTITY END_ENTITY|amod|estradiol	At 24 h , theca cells were treated with M199 , hCG -LRB- 15 ng/ml -RRB- , progesterone , estradiol , or DHT -LRB- 100 ng/ml -RRB- or a combination of hCG + one of the three steroids .
2891621	0	progesterone	48,60	hCG	13,16	progesterone	hCG	MESH:D011374	93659	Chemical	Gene	metabolism|nmod|START_ENTITY Influence|nmod|metabolism Influence|nmod|treatment treatment|compound|END_ENTITY	Influence of hCG treatment on the metabolism of progesterone and pregnenolone in vitro by the human undescended prepubertal testis .
3872132	0	progesterone	70,82	hCG	31,34	progesterone	hCG	MESH:D011374	93659	Chemical	Gene	START_ENTITY|nsubj|gonadotrophin gonadotrophin|appos|END_ENTITY	Serum chorionic gonadotrophin -LRB- hCG -RRB- , schwangerschaftsprotein 1 -LRB- SP1 -RRB- , progesterone and oestradiol levels in patients with nausea and vomiting in early pregnancy .
7942084	0	progesterone	26,38	hCG	60,63	progesterone	hCG	MESH:D011374	93659	Chemical	Gene	START_ENTITY|nmod|day day|nmod|administration administration|compound|END_ENTITY	The significance of serum progesterone levels on the day of hCG administration on IVF pregnancy rates .
19114373	0	progesterone	11,23	high_mobility_group_Box-1	27,52	progesterone	high mobility group Box-1	MESH:D011374	3146	Chemical	Gene	START_ENTITY|nmod|release release|amod|END_ENTITY	-LSB- Effect of progesterone on high_mobility_group_Box-1 protein-induced interleukin-6 release by human umbilic vein endothelial cells -RSB- .
1963323	0	progesterone	25,37	histone_H2A	10,21	progesterone	histone H2A	MESH:D011374	100299831	Chemical	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	Effect of histone_H2A on progesterone production by bovine luteal cells .
10963849	0	progesterone	53,65	inducible_nitric_oxide_synthase	101,132	progesterone	inducible nitric oxide synthase	MESH:D011374	18126(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY blocks|dobj|effect blocks|nmod|expression expression|amod|END_ENTITY	Onapristone -LRB- ZK299 -RRB- blocks the suppressive effect of progesterone , but not that of dexamethasone , on inducible_nitric_oxide_synthase gene expression and nitric_oxide production in murine macrophages .
15857396	0	progesterone	22,34	inducible_nitric_oxide_synthase	38,69	progesterone	inducible nitric oxide synthase	MESH:D011374	18126(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|amod|END_ENTITY	Modulatory effects of progesterone on inducible_nitric_oxide_synthase expression in vivo and in vitro .
1349597	0	progesterone	34,46	insulin	14,21	progesterone	insulin	MESH:D011374	3630	Chemical	Gene	production|amod|START_ENTITY effect|nmod|production effect|nmod|END_ENTITY	The effect of insulin on in vitro progesterone production of human granulosa cells .
16612012	0	progesterone	28,40	insulin	76,83	progesterone	insulin	MESH:D011374	105613195	Chemical	Gene	clearance|amod|START_ENTITY alterations|nmod|clearance appear|nsubj|alterations appear|xcomp|mediated mediated|nmod|END_ENTITY	Diet-induced alterations in progesterone clearance appear to be mediated by insulin signaling in hepatocytes .
23318859	0	progesterone	33,45	insulin	6,13	progesterone	insulin	MESH:D011374	3630	Chemical	Gene	treatment|amod|START_ENTITY Basal|nmod|treatment Basal|dobj|requirements requirements|compound|END_ENTITY	Basal insulin requirements after progesterone treatment in a type 1 diabetic pregnant woman .
6193139	12	progesterone	1776,1788	insulin	1975,1982	progesterone	insulin	MESH:D011374	397415(Tax:9823)	Chemical	Gene	production|amod|START_ENTITY augmentation|nmod|production reflected|nsubj|augmentation indicate|ccomp|reflected indicate|ccomp|acts acts|nsubj|END_ENTITY	Insulin 's augmentation of progesterone production reflected a selective action on progestin biosynthesis , since insulin significantly suppressed estrogen biosynthesis by granulosa cells.Thus , our investigations indicate that insulin acts on ovarian cells selectively to stimulate pregnenolone -LRB- but not estrogen -RRB- biosynthesis .
8505257	0	progesterone	108,120	insulin	11,18	progesterone	insulin	MESH:D011374	280829(Tax:9913)	Chemical	Gene	production|amod|START_ENTITY proliferation|appos|production END_ENTITY|nmod|proliferation	Effects of insulin , insulin-like_growth_factor_I , and gonadotropins on bovine granulosa cell proliferation , progesterone production , estradiol production , and -LRB- or -RRB- insulin-like_growth_factor_I production in vitro .
9225119	0	progesterone	87,99	insulin-like_growth_factor-I	12,40	progesterone	insulin-like growth factor-I	MESH:D011374	100008668(Tax:9986)	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	The role of insulin-like_growth_factor-I -LRB- IGF-I -RRB- and estradiol in rabbit corpus luteum progesterone production .
7593840	0	progesterone	63,75	interferon-tau	17,31	progesterone	interferon-tau	MESH:D011374	317698(Tax:9913)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of bovine interferon-tau on body temperature and plasma progesterone concentrations in cyclic dairy cows .
7546248	0	progesterone	86,98	interleukin-1_beta	32,50	progesterone	interleukin-1 beta	MESH:D011374	3553	Chemical	Gene	embryolethality|nmod|START_ENTITY embryolethality|nsubj|Prevention Prevention|nmod|END_ENTITY	Prevention of human recombinant interleukin-1_beta -LRB- rhIL-1 beta -RRB- embryolethality with progesterone or indomethacin .
8988519	0	progesterone	52,64	interleukin-1_beta	11,29	progesterone	interleukin-1 beta	MESH:D011374	281251(Tax:9913)	Chemical	Gene	beta|amod|START_ENTITY fragment|nmod|beta fragment|amod|END_ENTITY	Effects of interleukin-1_beta fragment -LRB- 163-171 -RRB- on progesterone and estradiol-17 beta release by bovine granulosa cells from different size follicles .
19114373	0	progesterone	11,23	interleukin-6	69,82	progesterone	interleukin-6	MESH:D011374	3569	Chemical	Gene	START_ENTITY|nmod|release release|amod|END_ENTITY	-LSB- Effect of progesterone on high_mobility_group_Box-1 protein-induced interleukin-6 release by human umbilic vein endothelial cells -RSB- .
7782982	0	progesterone	14,26	interleukin-6	30,43	progesterone	interleukin-6	MESH:D011374	3569	Chemical	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Modulation by progesterone of interleukin-6 production by gingival fibroblasts .
9681513	0	progesterone	88,100	interleukin-6	18,31	progesterone	interleukin-6	MESH:D011374	24498(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	The expression of interleukin-6 in the pregnant rat corpus luteum and its regulation by progesterone and glucocorticoid .
9834465	0	progesterone	93,105	interleukin-6	29,42	progesterone	interleukin-6	MESH:D011374	100008733(Tax:9986)	Chemical	Gene	secretion|compound|START_ENTITY production|nmod|secretion production|nmod|END_ENTITY	Rabbit ovarian production of interleukin-6 and its potential effects on gonadotropin-induced progesterone secretion in granulosa and theca cells .
8180676	0	progesterone	45,57	interleukin_2	10,23	progesterone	interleukin 2	MESH:D011374	3558	Chemical	Gene	production|nmod|START_ENTITY END_ENTITY|nmod|production	Effect of interleukin_2 on the production of progesterone and prostaglandin_E2 in human fetal membranes and its consequences for preterm uterine contractions .
8037668	0	progesterone	43,55	interleukin_8	15,28	progesterone	interleukin 8	MESH:D011374	100009129(Tax:9986)	Chemical	Gene	Suppression|nmod|START_ENTITY Suppression|nmod|production production|amod|END_ENTITY	Suppression of interleukin_8 production by progesterone in rabbit uterine cervix .
12276837	0	progesterone	25,37	kininogen	88,97	progesterone	kininogen	MESH:D011374	288001(Tax:10116)	Chemical	Gene	concentrations|amod|START_ENTITY concentrations|compound|END_ENTITY	Effect of oestrogens and progesterone alone and in combination on the female rat plasma kininogen concentrations .
10357956	8	progesterone	1320,1332	leptin	1276,1282	progesterone	Leptin	MESH:D011374	3952	Chemical	Gene	production|amod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	We conclude that leptin inhibits gonadotrophin-stimulated GC progesterone production apparently by antagonizing insulin action .
11056138	0	progesterone	47,59	leptin	85,91	progesterone	leptin	MESH:D011374	3952	Chemical	Gene	women|nmod|START_ENTITY Treatment|nmod|women prevents|nsubj|Treatment prevents|dobj|decrease decrease|nmod|concentrations concentrations|compound|END_ENTITY	Treatment of normal women with oestradiol plus progesterone prevents the decrease of leptin concentrations induced by ovariectomy .
12533410	0	progesterone	20,32	leptin	10,16	progesterone	leptin	MESH:D011374	3952	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of leptin on progesterone , human chorionic gonadotropin , and interleukin-6 secretion by human term trophoblast cells in culture .
14628651	0	progesterone	39,51	leptin	11,17	progesterone	leptin	MESH:D011374	25608(Tax:10116)	Chemical	Gene	production|nmod|START_ENTITY Effect|nmod|production Effect|nmod|END_ENTITY	-LSB- Effect of leptin in the production of progesterone and estradiol by ovarian rat tissue -RSB- .
16177544	0	progesterone	102,114	leptin	19,25	progesterone	leptin	MESH:D011374	396832(Tax:9823)	Chemical	Gene	secretion|amod|START_ENTITY stimulated|dobj|secretion stimulated|nmod|effect effect|nmod|END_ENTITY	In vitro effect of leptin on growth hormone -LRB- GH -RRB- - and insulin-like growth factor-I -LRB- IGF-I -RRB- - stimulated progesterone secretion and apoptosis in developing and mature corpora lutea of pig ovaries .
23580952	0	progesterone	106,118	leptin	19,25	progesterone	leptin	MESH:D011374	396832(Tax:9823)	Chemical	Gene	secretion|amod|START_ENTITY follicles|nmod|secretion steroidogenesis|nmod|follicles profile|nmod|steroidogenesis shift|dobj|profile shift|nsubj|levels levels|compound|END_ENTITY	Supraphysiological leptin levels shift the profile of steroidogenesis in porcine ovarian follicles toward progesterone and testosterone secretion through increased expressions of CYP11A1 and 17b-HSD : a tissue culture approach .
24101399	0	progesterone	41,53	leptin	76,82	progesterone	leptin	MESH:D011374	3952	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	In vitro effects of luteinizing hormone , progesterone and oestradiol-17b on leptin gene expression and leptin secretion by porcine luteal cells obtained in early pregnancy .
15639816	0	progesterone	68,80	leukemia_inhibitory_factor	31,57	progesterone	leukemia inhibitory factor	MESH:D011374	16878(Tax:10090)	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	-LSB- Relationship of expression of leukemia_inhibitory_factor gene with progesterone and estradiol in mouse endometrium -RSB- .
1315261	15	progesterone	2066,2078	mPL-I	2088,2093	progesterone	mPL-I	MESH:D011374	18775(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|amod|END_ENTITY	These data suggest that progesterone inhibits mPL-I secretion at least in part by inhibiting the differentiation of mPL-I-producing giant cells .
20096719	0	progesterone	47,59	mPRalpha	76,84	progesterone	mPRalpha	MESH:D011374	20200(Tax:10090)	Chemical	Gene	alpha|compound|START_ENTITY alpha|appos|END_ENTITY	Comparison between steroid binding to membrane progesterone receptor alpha -LRB- mPRalpha -RRB- and to nuclear_progesterone_receptor : correlation with physicochemical properties assessed by comparative molecular field analysis and identification of mPRalpha-specific agonists .
17443805	0	progesterone	11,23	microtubule-associated_protein_tau	177,211	progesterone	microtubule-associated protein tau	MESH:D011374	29477(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY synthase|nsubj|Effects synthase|dobj|END_ENTITY	Effects of progesterone and its reduced metabolites , dihydroprogesterone and tetrahydroprogesterone , on the expression and phosphorylation of glycogen synthase kinase-3 and the microtubule-associated_protein_tau in the rat cerebellum .
17405632	0	progesterone	25,37	milk	20,24	progesterone	milk	MESH:D011374	100532204	Chemical	Gene	START_ENTITY|nsubj|Radioimmunoassay Radioimmunoassay|nmod|END_ENTITY	Radioimmunoassay of milk progesterone as a tool for fertility control in smallholder dairy farms .
18049715	0	progesterone	54,66	neuregulin_1	27,39	progesterone	neuregulin 1	MESH:D011374	112400(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Differential regulation of neuregulin_1 expression by progesterone in astrocytes and neurons .
7506290	0	progesterone	89,101	neuropeptide_Y	20,34	progesterone	neuropeptide Y	MESH:D011374	504216(Tax:9913)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Multiple effects of neuropeptide_Y , substance_P and vasoactive_intestinal_polypeptide on progesterone and oxytocin release from bovine corpus luteum in vitro .
17341544	0	progesterone	51,63	organic_anion_transporter_4	20,47	progesterone	organic anion transporter 4	MESH:D011374	55867	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of human organic_anion_transporter_4 by progesterone and protein_kinase_C in human placental BeWo cells .
7264510	0	progesterone	20,32	ornithine_decarboxylase	54,77	progesterone	ornithine decarboxylase	MESH:D011374	421937(Tax:9031)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|activity activity|compound|END_ENTITY	Early inhibition by progesterone of oestrogen-induced ornithine_decarboxylase activity in the chick oviduct and rat uterus .
12954727	0	progesterone	45,57	oxytocin	25,33	progesterone	oxytocin	MESH:D011374	18429(Tax:10090)	Chemical	Gene	binding|nmod|START_ENTITY binding|nsubj|inhibition inhibition|nmod|END_ENTITY	Nongenomic inhibition of oxytocin binding by progesterone in the ovine uterus .
1444177	0	progesterone	62,74	oxytocin	17,25	progesterone	oxytocin	MESH:D011374	5020	Chemical	Gene	production|amod|START_ENTITY influence|nmod|production influence|nmod|END_ENTITY	The influence of oxytocin , vasopressin and their analogues on progesterone and testosterone production by porcine granulosa cells in vitro .
1653357	0	progesterone	55,67	oxytocin	36,44	progesterone	oxytocin	MESH:D011374	5020	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|infusion infusion|nmod|END_ENTITY	Effect of intra-ovarian infusion of oxytocin on plasma progesterone concentrations in pregnant ewes .
19457780	0	progesterone	26,38	oxytocin	14,22	progesterone	oxytocin	MESH:D011374	100152272(Tax:9823)	Chemical	Gene	secretion|amod|START_ENTITY effect|nmod|secretion effect|nmod|END_ENTITY	The effect of oxytocin on progesterone secretion , phosphoinositide hydrolysis and intracellular mobilisation of Ca2 + in porcine luteal cells .
7600764	2	progesterone	355,367	oxytocin	318,326	progesterone	oxytocin	MESH:D011374	5020	Chemical	Gene	production|nmod|START_ENTITY modulates|dobj|production modulates|nsubj|END_ENTITY	Bovine granulosa cells secrete oxytocin , and oxytocin modulates the production of progesterone by granulosa cells in vitro .
10705995	0	progesterone	107,119	p53	62,65	progesterone	p53	MESH:D011374	7157	Chemical	Gene	upregulated|nmod|START_ENTITY upregulated|nsubjpass|END_ENTITY	Bcl-2 , survivin and variant CD44 v7-v10 are downregulated and p53 is upregulated in breast_cancer cells by progesterone : inhibition of cell growth and induction of apoptosis .
25864740	0	progesterone	20,32	pgr	90,93	progesterone	pgr	MESH:D011374	5241	Chemical	Gene	treatment|amod|START_ENTITY Association|nmod|treatment Association|nmod|END_ENTITY	Association between progesterone and estradiol-17beta treatment and protein expression of pgr and pgrmc1 in porcine luminal epithelial cells : a real-time cell proliferation approach .
10694271	0	progesterone	15,27	pituitary_adenylate_cyclase-activating_polypeptide	53,103	progesterone	pituitary adenylate cyclase-activating polypeptide	MESH:D011374	24166(Tax:10116)	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|expression expression|amod|END_ENTITY	Involvement of progesterone in gonadotrophin-induced pituitary_adenylate_cyclase-activating_polypeptide gene expression in pre-ovulatory follicles of rat ovary .
8503848	0	progesterone	55,67	platelet-activating_factor	15,41	progesterone	platelet-activating factor	MESH:D011374	9768	Chemical	Gene	Stimulation|nmod|START_ENTITY Stimulation|nmod|synthesis synthesis|amod|END_ENTITY	Stimulation of platelet-activating_factor synthesis by progesterone and A23187 in human spermatozoa .
17220940	0	progesterone	20,32	proenkephalin	50,63	progesterone	proenkephalin	MESH:D011374	100294557(Tax:9940)	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|expression expression|compound|END_ENTITY	Effect of prolonged progesterone treatment on the proenkephalin mRNA gene expression and enkephalins concentration in the sheep brain .
17701593	0	progesterone	131,143	progesterone_induced_blocking_factor	29,65	progesterone	progesterone induced blocking factor	MESH:D011374	10464	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression and modulation of progesterone_induced_blocking_factor -LRB- PIBF -RRB- and innate immune factors in human leukemia cell lines by progesterone and mifepristone .
26524797	0	progesterone	148,160	progesterone_induced_blocking_factor	20,56	progesterone	progesterone induced blocking factor	MESH:D011374	10464	Chemical	Gene	exposed|xcomp|START_ENTITY women|acl|exposed rise|nmod|women rise|nsubj|levels levels|nmod|END_ENTITY	Serum levels of the progesterone_induced_blocking_factor do not precipitously rise in women with gynecologic_cancer in contrast to women exposed to progesterone .
26634256	0	progesterone	26,38	progesterone_induced_blocking_factor	134,170	progesterone	progesterone induced blocking factor	MESH:D011374	10464	Chemical	Gene	Evidence|acl|START_ENTITY stimulus|nsubj|Evidence stimulus|acl|cause cause|dobj|rise rise|nmod|protein protein|dep|END_ENTITY	Evidence that exposure to progesterone alone is a sufficient stimulus to cause a precipitous rise in the immunomodulatory protein the progesterone_induced_blocking_factor -LRB- PIBF -RRB- .
9161642	0	progesterone	160,172	progesterone_induced_blocking_factor	51,87	progesterone	progesterone induced blocking factor	MESH:D011374	10464	Chemical	Gene	women|amod|START_ENTITY trimester_spontaneous_abortions|nmod|women correlate|nmod|trimester_spontaneous_abortions correlate|nsubj|Expression Expression|nmod|protein protein|acl|known known|nmod|END_ENTITY	Expression of an immunomodulatory protein known as progesterone_induced_blocking_factor -LRB- PIBF -RRB- does not correlate with first trimester_spontaneous_abortions in progesterone supplemented women .
10611086	0	progesterone	94,106	progesterone_receptor	11,32	progesterone	progesterone receptor	MESH:D011374	5241	Chemical	Gene	secretion|nmod|START_ENTITY blockers|nmod|secretion blockers|nsubj|Effects Effects|nmod|END_ENTITY	Effects of progesterone_receptor blockers on human granulosa-luteal cell culture secretion of progesterone , estradiol , and relaxin .
10727250	0	progesterone	76,88	progesterone_receptor	35,56	progesterone	progesterone receptor	MESH:D011374	18667(Tax:10090)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Paracrine regulation of epithelial progesterone_receptor and lactoferrin by progesterone in the mouse uterus .
11747343	0	progesterone	141,153	progesterone_receptor	46,67	progesterone	progesterone receptor	MESH:D011374	5241	Chemical	Gene	analogues|amod|START_ENTITY functions|nmod|analogues studying|dobj|functions model|acl|studying cells|dep|model Demonstration|dep|cells Demonstration|nmod|properties properties|nmod|RU486 RU486|nmod|END_ENTITY	Demonstration of mixed properties of RU486 in progesterone_receptor -LRB- PR -RRB- - transfected MDA-MB-231 cells : a model for studying the functions of progesterone analogues .
14982969	0	progesterone	27,39	progesterone_receptor	61,82	progesterone	progesterone receptor	MESH:D011374	18667(Tax:10090)	Chemical	Gene	activity|nmod|START_ENTITY activity|nmod|mice mice|compound|END_ENTITY	Anticonvulsant activity of progesterone and neurosteroids in progesterone_receptor knockout mice .
15680344	0	progesterone	22,34	progesterone_receptor	55,76	progesterone	progesterone receptor	MESH:D011374	18667(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY undiminished|nsubjpass|effects undiminished|nmod|mice mice|compound|END_ENTITY	Anesthetic effects of progesterone are undiminished in progesterone_receptor knockout mice .
15945099	0	progesterone	68,80	progesterone_receptor	141,162	progesterone	progesterone receptor	MESH:D011374	5241	Chemical	Gene	START_ENTITY|nmod|cells cells|acl|transfected transfected|nmod|END_ENTITY	Gene regulation profile reveals consistent anticancer properties of progesterone in hormone-independent breast_cancer cells transfected with progesterone_receptor .
1595890	0	progesterone	140,152	progesterone_receptor	181,202	progesterone	progesterone receptor	MESH:D011374	5241	Chemical	Gene	START_ENTITY|nmod|plasma plasma|acl|using using|dobj|END_ENTITY	A method for characterization of endogenous ligands to orphan receptors belonging to the steroid hormone receptor superfamily -- isolation of progesterone from pregnancy plasma using progesterone_receptor ligand-binding domain .
16139444	0	progesterone	105,117	progesterone_receptor	14,35	progesterone	progesterone receptor	MESH:D011374	5241	Chemical	Gene	proteins|compound|START_ENTITY induced|nmod|proteins Expression|acl|induced Expression|nmod|END_ENTITY	Expression of progesterone_receptor -LRB- s -RRB- during capacitation and incidence of acrosome_reaction induced by progesterone and zona proteins in boar spermatozoa .
17015480	0	progesterone	149,161	progesterone_receptor	20,41	progesterone	progesterone receptor	MESH:D011374	5241	Chemical	Gene	required|nmod|START_ENTITY coactivator|acl|required coactivator|compound|END_ENTITY	TReP-132 is a novel progesterone_receptor coactivator required for the inhibition of breast_cancer cell growth and enhancement of differentiation by progesterone .
17138644	0	progesterone	81,93	progesterone_receptor	46,67	progesterone	progesterone receptor	MESH:D011374	5241	Chemical	Gene	regulation|amod|START_ENTITY mediating|dobj|regulation signaling|advcl|mediating signaling|dobj|actions actions|nmod|END_ENTITY	The role of extranuclear signaling actions of progesterone_receptor in mediating progesterone regulation of gene expression and the cell cycle .
17293450	0	progesterone	87,99	progesterone_receptor	38,59	progesterone	progesterone receptor	MESH:D011374	5241	Chemical	Gene	response|acl|START_ENTITY diminishes|dobj|response diminishes|nsubj|polymorphism polymorphism|nmod|END_ENTITY	The PROGINS polymorphism of the human progesterone_receptor diminishes the response to progesterone .
1737013	0	progesterone	47,59	progesterone_receptor	14,35	progesterone	progesterone receptor	MESH:D011374	5241	Chemical	Gene	binding|xcomp|START_ENTITY binding|nsubj|Modulation Modulation|nmod|END_ENTITY	Modulation of progesterone_receptor binding to progesterone response elements by positioned nucleosomes .
1839136	0	progesterone	69,81	progesterone_receptor	102,123	progesterone	progesterone receptor	MESH:D011374	25154(Tax:10116)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|RU486 RU486|compound|END_ENTITY	Inhibition of the tocolytic activity of atrial_natriuretic_factor by progesterone and potentiation by progesterone_receptor antagonist RU486 in rats .
18625316	0	progesterone	89,101	progesterone_receptor	112,133	progesterone	progesterone receptor	MESH:D011374	18667(Tax:10090)	Chemical	Gene	derivatives|nmod|START_ENTITY substituted|dobj|derivatives substituted|nmod|antagonists antagonists|compound|END_ENTITY	Synthesis and biological effect of halogen substituted phenyl_acetic_acid derivatives of progesterone as potent progesterone_receptor antagonists .
21315613	0	progesterone	96,108	progesterone_receptor	51,72	progesterone	progesterone receptor	MESH:D011374	5241	Chemical	Gene	activity|nmod|START_ENTITY activity|nmod|END_ENTITY	Biological activity and ligand binding mode to the progesterone_receptor of A-homo analogues of progesterone .
21531767	0	progesterone	18,30	progesterone_receptor	67,88	progesterone	progesterone receptor	MESH:D011374	5241	Chemical	Gene	action|amod|START_ENTITY counteracts|dobj|action counteracts|nmod|ubiquitination ubiquitination|acl|leading leading|xcomp|END_ENTITY	BRCA1 counteracts progesterone action by ubiquitination leading to progesterone_receptor degradation and epigenetic silencing of target promoters .
22960752	0	progesterone	110,122	progesterone_receptor	39,60	progesterone	progesterone receptor	MESH:D011374	25154(Tax:10116)	Chemical	Gene	progestins|amod|START_ENTITY Bimodal|nmod|progestins Bimodal|dobj|energy energy|nmod|END_ENTITY	Bimodal binding and free energy of the progesterone_receptor in the induction of female sexual receptivity by progesterone and synthetic progestins .
23242527	0	progesterone	124,136	progesterone_receptor	69,90	progesterone	progesterone receptor	MESH:D011374	25154(Tax:10116)	Chemical	Gene	ability|nmod:poss|START_ENTITY regulate|dobj|ability membrane|xcomp|regulate membrane|nsubj|interacts interacts|nmod|END_ENTITY	Plasminogen_activator_inhibitor_1_RNA-binding_protein interacts with progesterone_receptor membrane component 1 to regulate progesterone 's ability to maintain the viability of spontaneously immortalized granulosa cells and rat granulosa cells .
23651709	0	progesterone	109,121	progesterone_receptor	14,35	progesterone	progesterone receptor	MESH:D011374	18667(Tax:10090)	Chemical	Gene	beat|nmod|START_ENTITY mediates|ccomp|beat mediates|nsubj|END_ENTITY	The classical progesterone_receptor mediates the rapid reduction of fallopian tube ciliary beat frequency by progesterone .
24550466	0	progesterone	18,30	progesterone_receptor	79,100	progesterone	progesterone receptor	MESH:D011374	100033883(Tax:9796)	Chemical	Gene	defines|nmod|START_ENTITY defines|nsubj|agonist agonist|compound|END_ENTITY	Pregnancy without progesterone in horses defines a second endogenous biopotent progesterone_receptor agonist , 5a-dihydroprogesterone .
2766287	0	progesterone	172,184	progesterone_receptor	46,67	progesterone	progesterone receptor	MESH:D011374	5241	Chemical	Gene	relationship|nmod|START_ENTITY Comparison|nmod|relationship Comparison|nmod|assay assay|nmod|END_ENTITY	Comparison of an immunocytochemical assay for progesterone_receptor with a biochemical method of measurement and immunocytochemical examination of the relationship between progesterone and estrogen_receptors .
3033446	0	progesterone	10,22	progesterone_receptor	36,57	progesterone	progesterone receptor	MESH:D011374	5241	Chemical	Gene	injection|amod|START_ENTITY Effect|nmod|injection Effect|nmod|levels levels|compound|END_ENTITY	Effect of progesterone injection on progesterone_receptor levels and distribution in untreated and short-term Premarin-primed pre-menopausal and post-menopausal endometrium .
4368909	0	progesterone	14,26	progesterone_receptor	65,86	progesterone	progesterone receptor	MESH:D011374	396198(Tax:9031)	Chemical	Gene	Metabolism|nmod|START_ENTITY Metabolism|dep|relation relation|nmod|END_ENTITY	Metabolism of progesterone in the chick oviduct : relation to the progesterone_receptor and biological activity .
6708528	0	progesterone	55,67	progesterone_receptor	16,37	progesterone	progesterone receptor	MESH:D011374	396198(Tax:9031)	Chemical	Gene	treatments|compound|START_ENTITY Augmentation|nmod|treatments Augmentation|nmod|concentration concentration|compound|END_ENTITY	Augmentation of progesterone_receptor concentration by progesterone and estrogen treatments in the chick oviduct .
6850032	0	progesterone	113,125	progesterone_receptor	40,61	progesterone	progesterone receptor	MESH:D011374	101098742	Chemical	Gene	administration|nmod|START_ENTITY uteri|nmod|administration END_ENTITY|nmod|uteri	Subcellular compartmentalization of the progesterone_receptor in cat uteri following the acute administration of progesterone .
9453243	0	progesterone	74,86	progesterone_receptor	16,37	progesterone	progesterone receptor	MESH:D011374	396198(Tax:9031)	Chemical	Gene	action|compound|START_ENTITY organs|nmod|action Distribution|dep|organs Distribution|nmod|END_ENTITY	Distribution of progesterone_receptor in chicken : novel target organs for progesterone and estrogen action .
9603252	0	progesterone	84,96	progesterone_receptor	18,39	progesterone	progesterone receptor	MESH:D011374	25154(Tax:10116)	Chemical	Gene	basalis|nmod|START_ENTITY basalis|nsubj|Regulation Regulation|nmod|receptor receptor|compound|END_ENTITY	Regulation of the progesterone_receptor and estrogen receptor in decidua basalis by progesterone and estradiol during pregnancy .
9724815	0	progesterone	33,45	progesterone_receptor	122,143	progesterone	progesterone receptor	MESH:D011374	5241	Chemical	Gene	actions|nmod|START_ENTITY transduced|nsubjpass|actions transduced|nmod|END_ENTITY	The negative feedback actions of progesterone on gonadotropin-releasing_hormone secretion are transduced by the classical progesterone_receptor .
9795281	0	progesterone	59,71	progesterone_receptor	81,102	progesterone	progesterone receptor	MESH:D011374	25154(Tax:10116)	Chemical	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of 16alpha,17alpha-cyclohexane derivatives of progesterone with the progesterone_receptor from rat uterus .
9989224	0	progesterone	45,57	progesterone_receptor	85,106	progesterone	progesterone receptor	MESH:D011374	5241	Chemical	Gene	START_ENTITY|acl|using using|dobj|muteins muteins|nmod|END_ENTITY	Investigation of the binding interactions of progesterone using muteins of the human progesterone_receptor ligand binding domain designed on the basis of a three-dimensional protein model .
10397281	0	progesterone	47,59	prolactin	61,70	progesterone	prolactin	MESH:D011374	5617	Chemical	Gene	cortisol|dep|START_ENTITY cortisol|dep|END_ENTITY	Acute effect of alcohol on estradiol , estrone , progesterone , prolactin , cortisol , and luteinizing hormone in premenopausal women .
1167352	0	progesterone	15,27	prolactin	101,110	progesterone	prolactin	MESH:D011374	24683(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY control|nmod|secretion control|dep|levels levels|compound|END_ENTITY	The control of progesterone secretion during the estrous cycle and early pseudopregnancy in the rat : prolactin , gonadotropin and steroid levels associated with rescue of the corpus luteum of pseudopregnancy .
1628694	0	progesterone	20,32	prolactin	67,76	progesterone	prolactin	MESH:D011374	24683(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|synthesis synthesis|nmod|END_ENTITY	Indirect effects of progesterone on the synthesis and secretion of prolactin in mammotroph-enriched cells .
1915063	0	progesterone	25,37	prolactin	128,137	progesterone	prolactin	MESH:D011374	5617	Chemical	Gene	antibody|nmod|START_ENTITY interrupts|nsubj|antibody interrupts|advcl|curtailing curtailing|dobj|secretion secretion|nmod|complex complex|nmod|hormone hormone|compound|END_ENTITY	A monoclonal antibody to progesterone interrupts pregnancy in the hamster by curtailing secretion of the luteotropic complex of prolactin and follicle-stimulating hormone .
1968810	0	progesterone	39,51	prolactin	72,81	progesterone	prolactin	MESH:D011374	24683(Tax:10116)	Chemical	Gene	change|compound|START_ENTITY change|nmod|secretion secretion|compound|END_ENTITY	Positive feedback relationship between progesterone and daily change of prolactin secretion that develops functional corpora lutea in PMSG-induced first oestrous cycle in prepubertal rats .
2013883	0	progesterone	18,30	prolactin	100,109	progesterone	prolactin	MESH:D011374	5617	Chemical	Gene	Changes|nmod|START_ENTITY Changes|nmod|END_ENTITY	Changes in plasma progesterone and prolactin concentrations during the annual cycle and the role of prolactin in the maintenance of lactation and luteal development in the Antarctic fur seal -LRB- Arctocephalus gazella -RRB- .
2020258	0	progesterone	15,27	prolactin	60,69	progesterone	prolactin	MESH:D011374	24683(Tax:10116)	Chemical	Gene	Replacement|nmod|START_ENTITY restores|nsubj|Replacement restores|dobj|surge surge|nmod|suppression suppression|compound|END_ENTITY	Replacement of progesterone restores the nocturnal surge of prolactin following suppression with a gonadotropin-releasing hormone agonist during early pregnancy in the rat .
25299230	0	progesterone	4,16	prolactin	49,58	progesterone	prolactin	MESH:D011374	19109(Tax:10090)	Chemical	Gene	modify|nsubj|START_ENTITY modify|dobj|END_ENTITY	The progesterone and estrogen modify the uterine prolactin and prolactin_receptor expression of hyperprolactinemic mice .
26740274	0	progesterone	80,92	prolactin	4,13	progesterone	Prolactin	MESH:D011374	5617	Chemical	Gene	women|amod|START_ENTITY lower|dobj|women contribute|xcomp|lower contribute|nsubj|END_ENTITY	Low prolactin and high 20alpha-hydroxysteroid dehydrogenase contribute to lower progesterone in HIV-infected protease inhibitor-cART exposed pregnant women .
2703990	0	progesterone	15,27	prolactin	74,83	progesterone	prolactin	MESH:D011374	24683(Tax:10116)	Chemical	Gene	Development|nmod|START_ENTITY dependency|nsubj|Development dependency|nmod|appearance appearance|nmod|surge surge|compound|END_ENTITY	Development of progesterone dependency in the appearance of the nocturnal prolactin surge in immature rats .
2717543	0	progesterone	51,63	prolactin	22,31	progesterone	prolactin	MESH:D011374	5617	Chemical	Gene	secretion|compound|START_ENTITY END_ENTITY|nmod|secretion	Stimulatory effect of prolactin on human placental progesterone secretion at term in vitro : possible inhibitory effect on oestradiol secretion .
2918266	0	progesterone	23,35	prolactin	54,63	progesterone	prolactin	MESH:D011374	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	Feedback regulation by progesterone of stress-induced prolactin release in rats .
2944979	0	progesterone	85,97	prolactin	15,24	progesterone	prolactin	MESH:D011374	24683(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY influence|nmod|treatment release|dep|influence release|compound|END_ENTITY	Stress-induced prolactin release in female , male and androgenized rats : influence of progesterone treatment .
4062899	0	progesterone	14,26	prolactin	30,39	progesterone	prolactin	MESH:D011374	100009394(Tax:9986)	Chemical	Gene	START_ENTITY|nmod|stimulation stimulation|compound|END_ENTITY	The effect of progesterone on prolactin stimulation of fatty_acid synthesis , glycerolipid synthesis and lipogenic-enzyme activities in mammary glands of pseudopregnant rabbits , after explant culture or intraductal injection .
4092671	0	progesterone	11,23	prolactin	27,36	progesterone	prolactin	MESH:D011374	5617	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of progesterone on prolactin secretion in hypogonadal women .
4218958	0	progesterone	14,26	prolactin	55,64	progesterone	prolactin	MESH:D011374	100009394(Tax:9986)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|effect effect|nmod|END_ENTITY	Inhibition by progesterone of the lactogenic effect of prolactin in the pseudopregnant rabbit .
428227	0	progesterone	66,78	prolactin	30,39	progesterone	prolactin	MESH:D011374	5617	Chemical	Gene	using|dobj|START_ENTITY study|acl|using study|nmod|levels levels|compound|END_ENTITY	A prospective study of plasma prolactin levels in women using the progesterone releasing intrauterine device -LRB- P-IUD -RRB- .
638868	0	progesterone	22,34	prolactin	11,20	progesterone	prolactin	MESH:D011374	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of prolactin , progesterone , and 17beta-hydroxy-5alpha-androstan-3-one on squalene production by the preputial gland of the immature female rat .
7077605	0	progesterone	102,114	prolactin	25,34	progesterone	prolactin	MESH:D011374	396965(Tax:9823)	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|concentrations concentrations|nmod|beta beta|compound|relaxin relaxin|compound|END_ENTITY	Plasma concentrations of prolactin , progesterone , relaxin and oestradiol-17 beta in sows treated with progesterone , bromocriptine or indomethacin during late pregnancy .
7410533	0	progesterone	82,94	prolactin	23,32	progesterone	prolactin	MESH:D011374	5617	Chemical	Gene	estradiol|compound|START_ENTITY secretion|nmod|estradiol effect|nmod|secretion have|dobj|effect have|nsubj|changes changes|nmod|concentration concentration|compound|END_ENTITY	Acute changes in serum prolactin concentration have no effect on the secretion of progesterone , estradiol , or chorionic gonadotropin during early pregnancy .
7780003	0	progesterone	92,104	prolactin	28,37	progesterone	prolactin	MESH:D011374	5617	Chemical	Gene	START_ENTITY|nsubj|patterns patterns|nmod|secretion secretion|compound|END_ENTITY	Daily patterns of pituitary prolactin secretion and their role in regulating maternal serum progesterone concentrations across pregnancy in the Djungarian hamster -LRB- Phodopus campbelli -RRB- .
7803622	0	progesterone	64,76	prolactin	103,112	progesterone	prolactin	MESH:D011374	5617	Chemical	Gene	antibody|acl|START_ENTITY hamster|nmod|antibody effects|nmod|hamster reversed|nsubjpass|effects reversed|nmod|END_ENTITY	Abortifacient effects in the pregnant hamster of an antibody to progesterone are reversed by exogenous prolactin .
9795359	0	progesterone	58,70	prolactin	37,46	progesterone	prolactin	MESH:D011374	396965(Tax:9823)	Chemical	Gene	START_ENTITY|nsubj|stimulates stimulates|compound|END_ENTITY	Assessment of the mechanism by which prolactin stimulates progesterone production by early corpora lutea of pigs .
16107292	0	progesterone	185,197	prolactin_receptor	71,89	progesterone	prolactin receptor	MESH:D011374	24684(Tax:10116)	Chemical	Gene	regimen|nmod|START_ENTITY exposure|nmod|regimen Effects|nmod|exposure alterations|dep|Effects alterations|nmod|expression expression|nmod|form form|nmod|END_ENTITY	Steroid-induced alterations in mRNA expression of the long form of the prolactin_receptor in the medial preoptic area of female rats : Effects of exposure to a pregnancy-like regimen of progesterone and estradiol .
21521814	0	progesterone	84,96	prolactin_receptor	14,32	progesterone	prolactin receptor	MESH:D011374	281422(Tax:9913)	Chemical	Gene	cycle|amod|START_ENTITY regulation|nmod|cycle involvement|nmod|regulation expression|dep|involvement expression|compound|END_ENTITY	Bovine luteal prolactin_receptor expression : potential involvement in regulation of progesterone during the estrous cycle and pregnancy .
9626159	0	progesterone	17,29	proliferating_cell_nuclear_antigen	33,67	progesterone	proliferating cell nuclear antigen	MESH:D011374	5111	Chemical	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|expression expression|compound|END_ENTITY	Up-regulation by progesterone of proliferating_cell_nuclear_antigen and epidermal_growth_factor expression in human uterine_leiomyoma .
11078439	0	progesterone	49,61	renin	164,169	progesterone	renin	MESH:D011374	5972	Chemical	Gene	active|amod|START_ENTITY END_ENTITY|amod|active	Plasma endothelin and LH-RH , LH , FSH , prolactin , progesterone , 17alpha-hydroxyprogesterone , estrone , 17beta-estradiol , delta4-androstenedione , testosterone , active renin , angiotensin-II and ANP levels in blood and LH , estrone and 17beta-estradiol and pregnanediol levels in urine of normal cycling women .
1149405	0	progesterone	10,22	renin	101,106	progesterone	renin	MESH:D011374	5972	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|relation relation|acl|aldosterone aldosterone|dobj|activity activity|compound|END_ENTITY	Effect of progesterone on renal sodium handling in man : relation to aldosterone excretion and plasma renin activity .
11499018	0	progesterone	72,84	renin	39,44	progesterone	renin	MESH:D011374	5972	Chemical	Gene	-RSB-|amod|START_ENTITY Modulation|nmod|-RSB- Modulation|nmod|secretion secretion|nmod|END_ENTITY	-LSB- Modulation of the secretion of active renin in human decidual cells by progesterone -RSB- .
2014841	0	progesterone	10,22	renin	26,31	progesterone	renin	MESH:D011374	5972	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of progesterone on renin secretion in endometrial stromal , chorionic trophoblast , and mesenchymal monolayer cultures .
3305759	0	progesterone	21,33	renin	65,70	progesterone	renin	MESH:D011374	24715(Tax:10116)	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Hormone profiles for progesterone , oestradiol , prolactin , plasma renin activity , aldosterone and corticosterone during pregnancy and pseudopregnancy in two strains of rat : correlation with renal studies .
14521952	0	progesterone	80,92	secretory_leukocyte_protease_inhibitor	27,65	progesterone	secretory leukocyte protease inhibitor	MESH:D011374	6590	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of secretory_leukocyte_protease_inhibitor and elafin by progesterone .
7159296	0	progesterone	11,23	steroid_receptor	47,63	progesterone	steroid receptor	MESH:D011374	443066(Tax:9940)	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Effects of progesterone on nuclear and cytosol steroid_receptor levels in the oestrogen-stimulated uterus : comparison of the sheep and mouse .
12604660	0	progesterone	22,34	steroidogenic_acute_regulatory_protein	56,94	progesterone	steroidogenic acute regulatory protein	MESH:D011374	20845(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|nmod|END_ENTITY	Stimulatory effect of progesterone on the expression of steroidogenic_acute_regulatory_protein in MA-10 Leydig cells .
11005131	0	progesterone	45,57	transferrin	22,33	progesterone	transferrin	MESH:D011374	7018	Chemical	Gene	production|amod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	-LSB- Human amniotic fluid transferrin stimulates progesterone production by human trophoblast cells in vitro -RSB- .
15188799	0	progesterone	56,68	transferrin	34,45	progesterone	transferrin	MESH:D011374	7018	Chemical	Gene	production|amod|START_ENTITY stimulate|dobj|production stimulate|nsubj|N-glycans N-glycans|nmod|END_ENTITY	N-glycans of human amniotic fluid transferrin stimulate progesterone production in human first trimester trophoblast cells in vitro .
7557634	0	progesterone	36,48	transferrin	21,32	progesterone	transferrin	MESH:D011374	7018	Chemical	Gene	production|amod|START_ENTITY effect|nmod|production effect|nmod|END_ENTITY	Inhibitory effect of transferrin on progesterone production in the granulosa cell of humans in vivo and porcine granulosa cell in vitro .
7648911	0	progesterone	33,45	tumor_necrosis_factor	49,70	progesterone	tumor necrosis factor	MESH:D011374	7124	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	-LSB- The regulation of estradiol and progesterone in tumor_necrosis_factor production in vitro -RSB- .
16891052	0	progesterone	55,67	tumor_necrosis_factor-alpha	13,40	progesterone	tumor necrosis factor-alpha	MESH:D011374	7124	Chemical	Gene	growth|amod|START_ENTITY END_ENTITY|nmod|growth	Influence of tumor_necrosis_factor-alpha on estradiol , progesterone , insulin-like growth factor-II , and insulin-like_growth_factor_binding_protein-1 , _ 2 , _ and_3 in cultured human luteinized granulosa cells .
7684743	0	progesterone	32,44	tumor_necrosis_factor-alpha	109,136	progesterone	tumor necrosis factor-alpha	MESH:D011374	7124	Chemical	Gene	action|amod|START_ENTITY associated|nmod|action fever|acl|associated elevated|nsubj|fever elevated|dobj|levels levels|nmod|END_ENTITY	Recurrent fever associated with progesterone action and persistently elevated serum levels of immunoreactive tumor_necrosis_factor-alpha and interleukin-6 .
8522236	0	progesterone	58,70	tumor_necrosis_factor-alpha	26,53	progesterone	tumor necrosis factor-alpha	MESH:D011374	7124	Chemical	Gene	synthesis|amod|START_ENTITY -LSB-|nmod|synthesis -LSB-|dobj|effect effect|appos|END_ENTITY	-LSB- The effect of TNF-alpha -LRB- tumor_necrosis_factor-alpha -RRB- on progesterone synthesis in vitro by cells from ovarian follicular fluid in women -RSB- .
9171974	0	progesterone	41,53	tumor_necrosis_factor-alpha	10,37	progesterone	tumor necrosis factor-alpha	MESH:D011374	7124	Chemical	Gene	production|amod|START_ENTITY Effect|nmod|production Effect|nmod|END_ENTITY	Effect of tumor_necrosis_factor-alpha on progesterone production by granulosa cells in laying hens of different genetic lines .
2183616	0	progesterone	110,122	tumor_necrosis_factor_alpha	50,77	progesterone	tumor necrosis factor alpha	MESH:D011374	21926(Tax:10090)	Chemical	Gene	accumulation|compound|START_ENTITY inhibits|dobj|accumulation inhibits|nsubj|END_ENTITY	Cytokine-mediated regulation of ovarian function : tumor_necrosis_factor_alpha inhibits gonadotropin-supported progesterone accumulation by differentiating and luteinized murine granulosa cells .
2886358	0	progesterone	25,37	tyrosine_aminotransferase	57,82	progesterone	tyrosine aminotransferase	MESH:D011374	24813(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	Dual effect of exogenous progesterone on the activity of tyrosine_aminotransferase in the liver of female rats .
12798890	0	progesterone	44,56	vascular_endothelial_growth_factor	69,103	progesterone	vascular endothelial growth factor	MESH:D011374	7422	Chemical	Gene	START_ENTITY|nmod|mRNA mRNA|nmod|END_ENTITY	Effect of raloxifene , 17beta-estradiol , and progesterone on mRNA for vascular_endothelial_growth_factor isoforms 121 and 165 and thrombospondin-1 in Ishikawa cells .
24998155	0	progesterone	60,72	vascular_endothelial_growth_factor	22,56	progesterone	vascular endothelial growth factor	MESH:D011374	7422	Chemical	Gene	production|amod|START_ENTITY effect|nmod|production effect|nmod|END_ENTITY	Stimulatory effect of vascular_endothelial_growth_factor on progesterone production and survivability of cultured bubaline luteal cells .
26143364	0	progesterone	152,164	vascular_endothelial_growth_factor	27,61	progesterone	vascular endothelial growth factor	MESH:D011374	7422	Chemical	Gene	level|compound|START_ENTITY have|dobj|level women|acl:relcl|have compartments|nmod|women compartments|nsubj|expression expression|nmod|factors factors|amod|END_ENTITY	Differential expression of vascular_endothelial_growth_factor angiogenic factors in different endometrial compartments in women who have an elevated progesterone level before oocyte retrieval , during in vitro fertilization-embryo transfer treatment .
26143364	0	progesterone	152,164	vascular_endothelial_growth_factor	27,61	progesterone	vascular endothelial growth factor	MESH:D011374	7422	Chemical	Gene	level|compound|START_ENTITY have|dobj|level women|acl:relcl|have compartments|nmod|women compartments|nsubj|expression expression|nmod|factors factors|amod|END_ENTITY	Differential expression of vascular_endothelial_growth_factor angiogenic factors in different endometrial compartments in women who have an elevated progesterone level before oocyte retrieval , during in vitro fertilization-embryo transfer treatment .
11558590	0	progesterone_esters	4,23	5alpha-reductase	27,43	progesterone esters	5alpha-reductase	null	6715	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	New progesterone_esters as 5alpha-reductase inhibitors .
10509795	0	progestin	52,61	Androgen_receptor	0,17	progestin	Androgen receptor	CHEBI:59826	367	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Androgen_receptor agonist activity of the synthetic progestin , medroxyprogesterone_acetate , in human breast_cancer cells .
20519331	0	progestin	88,97	Elf5	140,144	progestin	Elf5	CHEBI:59826	2001	Chemical	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	The antiproliferative effects of progestins in T47D breast_cancer cells are tempered by progestin induction of the ETS transcription factor Elf5 .
21131554	0	progestin	58,67	FOXO1	30,35	progestin	FOXO1	CHEBI:59826	2308	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Forkhead transcription factor FOXO1 is a direct target of progestin to inhibit endometrial epithelial cell growth .
1964636	0	progestin	47,56	epidermal_growth_factor	14,37	progestin	epidermal growth factor	CHEBI:59826	25313(Tax:10116)	Chemical	Gene	secretion|compound|START_ENTITY effect|nmod|secretion effect|nmod|END_ENTITY	The effect of epidermal_growth_factor -LRB- EGF -RRB- on progestin secretion and cyclic_AMP synthesis in cultured luteal cells from pregnant rats .
6288675	0	progestin	22,31	epidermal_growth_factor	46,69	progestin	epidermal growth factor	CHEBI:59826	25313(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Regulation of ovarian progestin production by epidermal_growth_factor in cultured rat granulosa cells .
6790199	0	progestin	123,132	hepatic_lipase	92,106	progestin	hepatic lipase	CHEBI:59826	3990	Chemical	Gene	treatment|compound|START_ENTITY END_ENTITY|nmod|treatment	Reduction of plasma high-density lipoprotein cholesterol and increase of postheparin plasma hepatic_lipase activity during progestin treatment .
24695628	0	progestin	93,102	mPRalpha	119,127	progestin	mPRalpha	CHEBI:59826	20200(Tax:10090)	Chemical	Gene	receptor-alpha|compound|START_ENTITY receptor-alpha|appos|END_ENTITY	Activation of the Pi3k/Akt pathway and modulation of phosphodiesterase activity via membrane progestin receptor-alpha -LRB- mPRalpha -RRB- regulate progestin-initiated sperm_hypermotility in Atlantic croaker .
1831804	0	progestin	74,83	macrophage-colony-stimulating_factor	26,62	progestin	macrophage-colony-stimulating factor	CHEBI:59826	1435	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|effects effects|nmod|END_ENTITY	The biological effects of macrophage-colony-stimulating_factor induced by progestin on growth and differentiation of endometrial_adenocarcinoma cells .
12374462	0	progestin_R5020	46,61	Cyr61	22,27	progestin R5020	Cyr61	null	3491	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	The angiogenic factor Cyr61 is induced by the progestin_R5020 and is necessary for mammary adenocarcinoma cell growth .
15531127	0	progestins	11,21	C-reactive_protein	54,72	progestins	C-reactive protein	MESH:D011372	1401	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of progestins on estrogen-induced increase in C-reactive_protein in postmenopausal women .
9361392	0	progestins	10,20	IGF-I	24,29	progestins	IGF-I	MESH:D011372	3479	Chemical	Gene	START_ENTITY|nmod|level level|amod|END_ENTITY	Effect of progestins on IGF-I serum level in estrogen-treated postmenopausal women .
11304678	2	progestins	468,478	VEGF	308,312	progestins	VEGF	MESH:D011372	7422	Chemical	Gene	elevated|nmod|START_ENTITY cells|acl:relcl|elevated regulated|nmod|cells regulated|nsubjpass|expression expression|compound|END_ENTITY	VEGF expression is regulated by steroid hormones in a number of systems , including T47-D human breast_cancer cells in which VEGF protein levels are elevated by progestins .
17413000	0	progestins	55,65	androgen_receptor	14,31	progestins	androgen receptor	MESH:D011372	367	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Disruption of androgen_receptor signaling by synthetic progestins may increase risk of developing breast_cancer .
2229140	0	progestins	40,50	androgen_receptor	19,36	progestins	androgen receptor	MESH:D011372	367	Chemical	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|nmod|END_ENTITY	Down-regulation of androgen_receptor by progestins and interference with estrogenic or androgenic stimulation of mammary_carcinoma cell growth .
6234148	0	progestins	111,121	apo-lipoprotein_AI	17,35	progestins	apo-lipoprotein AI	MESH:D011372	335	Chemical	Gene	treatment|nmod|START_ENTITY END_ENTITY|nmod|treatment	Changes in serum apo-lipoprotein_AI and sex-hormone-binding globulin levels after treatment with two different progestins administered alone and in combination with ethinyl_estradiol .
3158321	0	progestins	15,25	endothelial_lipase	74,92	progestins	endothelial lipase	MESH:D011372	9388	Chemical	Gene	START_ENTITY|nmod|properties properties|nmod|END_ENTITY	Effects of two progestins with different androgenic properties on hepatic endothelial_lipase and high density lipoprotein2 .
169281	0	progestins	11,21	estradiol_receptor	25,43	progestins	estradiol receptor	MESH:D011372	2099	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Effects of progestins on estradiol_receptor levels in human endometrium .
2996526	0	progestins	70,80	growth_hormone	14,28	progestins	growth hormone	MESH:D011372	2688	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|receptors receptors|compound|END_ENTITY	Regulation of growth_hormone and epidermal_growth_factor receptors by progestins in breast_cancer cells .
6460509	0	progestins	25,35	hepatic_lipase	101,115	progestins	hepatic lipase	MESH:D011372	3990	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nsubj|effects	Different effects of two progestins on plasma high density lipoprotein -LRB- HDL2 -RRB- and postheparin plasma hepatic_lipase activity .
23813454	0	progestins	87,97	matrix_metalloproteinase_9	118,144	progestins	matrix metalloproteinase 9	MESH:D011372	4318	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Progesterone_receptor_membrane_component_1 as the mediator of the inhibitory effect of progestins on cytokine-induced matrix_metalloproteinase_9 activity in vitro .
16049127	0	progestins	15,25	multidrug_resistance-associated_protein_2	41,82	progestins	multidrug resistance-associated protein 2	MESH:D011372	1244	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of progestins with the human multidrug_resistance-associated_protein_2 -LRB- MRP2 -RRB- .
1457040	0	progestins	14,24	prolactin_receptor	28,46	progestins	prolactin receptor	MESH:D011372	5618	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	The effect of progestins on prolactin_receptor gene transcription in human breast_cancer cells .
11304678	0	progestins	31,41	vascular_endothelial_growth_factor	49,83	progestins	vascular endothelial growth factor	MESH:D011372	7422	Chemical	Gene	START_ENTITY|xcomp|induce induce|dobj|expression expression|compound|END_ENTITY	Pharmacological and endogenous progestins induce vascular_endothelial_growth_factor expression in human breast_cancer cells .
1751397	0	progestogens	29,41	estrone_sulfatase	45,62	progestogens	estrone sulfatase	MESH:D011372	412	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	In vitro effect of synthetic progestogens on estrone_sulfatase activity in human breast_carcinoma .
2027496	0	proglumide	38,48	CCK	52,55	proglumide	CCK	null	885	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Treatment of Parkinson 's _ disease with proglumide , a CCK antagonist .
3432123	0	proglumide	17,27	CCK	40,43	proglumide	CCK	null	885	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	The influence of proglumide , a putative CCK antagonist , on cerebral_ischemia in gerbil .
18207473	0	proglumide	43,53	cholecystokinin	8,23	proglumide	cholecystokinin	null	885	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of cholecystokinin and its antagonist proglumide on macronutrient selection in European sea bass Dicentrarchus labrax , L. Teleost fish are able to adjust their energy intake when fed on pure macronutrient sources , although the exact mechanisms regulating macronutrient selection remain unknown .
3087585	0	proglumide	47,57	cholecystokinin	19,34	proglumide	cholecystokinin	null	25298(Tax:10116)	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|END_ENTITY	The effects of the cholecystokinin antagonist , proglumide , on gonadotropin release in the rat .
3807652	0	proglumide	47,57	cholecystokinin	19,34	proglumide	cholecystokinin	null	25298(Tax:10116)	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|END_ENTITY	The effects of the cholecystokinin antagonist , proglumide , on prolactin secretion in the rat .
4014744	0	proglumide	57,67	cholecystokinin	71,86	proglumide	cholecystokinin	null	885	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Potentiation of systemic morphine analgesia in humans by proglumide , a cholecystokinin antagonist .
6463283	0	proglumide	32,42	cholecystokinin	4,19	proglumide	cholecystokinin	null	25298(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	The cholecystokinin antagonist , proglumide , increases food intake in the rat .
3621187	0	proglumide	116,126	gastrin	130,137	proglumide	gastrin	null	14459(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Inhibition of pentagastrin-stimulated up-regulation of gastrin receptors and growth of mouse colon_tumor in vivo by proglumide , a gastrin receptor antagonist .
11263367	0	proglumide	11,21	gastrin_receptor	25,41	proglumide	gastrin receptor	null	887	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Effects of proglumide , a gastrin_receptor antagonist , on human large intestine carcinoma SW480 cell line .
2207995	0	proglumide	46,56	gastrin_receptor	18,34	proglumide	gastrin receptor	null	887	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|antagonist antagonist|compound|END_ENTITY	The effect of the gastrin_receptor antagonist proglumide on survival in gastric_carcinoma .
2209837	0	proglumide	36,46	gastrin_receptor	50,66	proglumide	gastrin receptor	null	887	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	A pilot randomized control trial of proglumide -LRB- a gastrin_receptor antagonist -RRB- in advanced colorectal_cancer .
11501186	0	proguanil	9,18	CYP2C19	60,67	proguanil	CYP2C19	MESH:D002727	1557	Chemical	Gene	mediated|advcl|START_ENTITY mediated|nmod|END_ENTITY	In vitro proguanil activation to cycloguanil is mediated by CYP2C19 and CYP3A4 in adult Chinese liver microsomes .
10675531	0	prokallikrein	64,77	High-molecular-weight_kininogen	0,31	prokallikrein	High-molecular-weight kininogen	null	3827	Chemical	Gene	protein|nmod|START_ENTITY protein|nsubj|END_ENTITY	High-molecular-weight_kininogen is a binding protein for tissue prokallikrein .
16687502	0	prokineticin	65,77	transient_receptor_potential_vanilloid_1	17,57	prokineticin	transient receptor potential vanilloid 1	null	7442	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	Sensitization of transient_receptor_potential_vanilloid_1 by the prokineticin receptor agonist Bv8 .
14502423	0	proline	13,20	ASCT1	76,81	proline	ASCT1	CHEBI:26271	6509	Chemical	Gene	Transport|nmod|START_ENTITY Transport|nmod|END_ENTITY	Transport of proline and hydroxyproline by the neutral amino-acid exchanger ASCT1 .
1356808	0	proline	46,53	CA1	57,60	proline	CA1	CHEBI:26271	759	Chemical	Gene	START_ENTITY|nmod|cells cells|nummod|END_ENTITY	NMDA receptor-mediated depolarizing action of proline on CA1 pyramidal cells .
12168769	0	proline	39,46	CAMP-dependent_protein_kinase	0,29	proline	CAMP-dependent protein kinase	CHEBI:26271	171150(Tax:10116)	Chemical	Gene	transport|amod|START_ENTITY inhibits|dobj|transport inhibits|nsubj|END_ENTITY	CAMP-dependent_protein_kinase inhibits proline transport across the rat renal tubular brush border membrane .
26919535	0	proline	28,35	COMT	12,16	proline	COMT	CHEBI:26271	1312	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	The role of COMT and plasma proline in the variable penetrance of autistic spectrum symptoms in 22q11 .2 Deletion Syndrome .
10744628	0	proline	21,28	Dopamine_transporter	0,20	proline	Dopamine transporter	CHEBI:26271	6531	Chemical	Gene	mutations|compound|START_ENTITY mutations|amod|END_ENTITY	Dopamine_transporter proline mutations influence dopamine uptake , cocaine analog recognition , and expression .
8789253	0	proline	26,33	HSP47	87,92	proline	HSP47	CHEBI:26271	871	Chemical	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Age-related alteration of proline hydroxylase and collagen-binding heat_shock protein -LRB- HSP47 -RRB- expression in human fibroblasts .
17300219	0	proline	2,9	MAML1	50,55	proline	MAML1	CHEBI:26271	9794	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	A proline repeat domain in the Notch co-activator MAML1 is important for the p300-mediated acetylation of MAML1 .
17494643	0	proline	42,49	MRP1	61,65	proline	MRP1	CHEBI:26271	4363	Chemical	Gene	residue|compound|START_ENTITY residue|nmod|END_ENTITY	Mutational analysis of a highly conserved proline residue in MRP1 , MRP2 , and MRP3 reveals a partially conserved function .
16668837	2	proline	695,702	P5CR	717,721	proline	P5CR	CHEBI:26271	547907(Tax:3847)	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	The K -LRB- 1 -RRB- for proline inhibition of P5CR in bacteroid cytosol was 1.8 millimolar .
2541599	0	proline	34,41	Parathyroid_hormone	0,19	proline	Parathyroid hormone	CHEBI:26271	19226(Tax:10090)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Parathyroid_hormone regulation of proline uptake by cultured neonatal mouse osteoblastlike cells .
2742596	0	proline	54,61	Parathyroid_hormone	0,19	proline	Parathyroid hormone	CHEBI:26271	19226(Tax:10090)	Chemical	Gene	activities|amod|START_ENTITY alteration|nmod|activities END_ENTITY|dobj|alteration	Parathyroid_hormone alteration of free and tRNA-bound proline specific activities in cultured mouse osteoblast-like cells .
22796327	0	proline	39,46	Proline_dehydrogenase	0,21	proline	Proline dehydrogenase	CHEBI:26271	5625	Chemical	Gene	protection|amod|START_ENTITY essential|nmod|protection essential|nsubj|END_ENTITY	Proline_dehydrogenase is essential for proline protection against hydrogen_peroxide-induced cell death .
25982064	0	proline	70,77	alkaline_phosphatase	42,62	proline	alkaline phosphatase	CHEBI:26271	250	Chemical	Gene	phenotype|nmod|START_ENTITY phenotype|nmod|END_ENTITY	Molecular phenotype of tissue-nonspecific alkaline_phosphatase with a proline -LRB- 108 -RRB- to leucine substitution associated with dominant odontohypophosphatasia .
25982064	0	proline	70,77	alkaline_phosphatase	42,62	proline	alkaline phosphatase	CHEBI:26271	250	Chemical	Gene	phenotype|nmod|START_ENTITY phenotype|nmod|END_ENTITY	Molecular phenotype of tissue-nonspecific alkaline_phosphatase with a proline -LRB- 108 -RRB- to leucine substitution associated with dominant odontohypophosphatasia .
22145976	0	proline	51,58	alpha-1	43,50	proline	alpha-1	CHEBI:26271	146	Chemical	Gene	mutations|compound|START_ENTITY mutations|amod|END_ENTITY	HLA-B * 08:01:08 - joining the fold of silent alpha-1 proline mutations in HLA-B .
12890816	0	proline	98,105	apolipoprotein_B-100	155,175	proline	apolipoprotein B-100	CHEBI:26271	338	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Measurement of 5-hydroxy-2-aminovaleric_acid as a specific marker of metal catalysed oxidation of proline and arginine residues of low density lipoprotein apolipoprotein_B-100 in human atherosclerotic_lesions .
19331814	0	proline	20,27	dynamin-2	43,52	proline	dynamin-2	CHEBI:26271	1785	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	New function of the proline rich domain in dynamin-2 to negatively regulate its interaction with microtubules in mammalian cells .
1419149	0	proline	25,32	insulin	10,17	proline	insulin	CHEBI:26271	3630	Chemical	Gene	activity|amod|START_ENTITY Effect|nmod|activity Effect|nmod|END_ENTITY	Effect of insulin on the proline transport activity in cultured fibroblasts from patients with Werner_syndrome .
10606845	0	proline	6,13	keratin_16	40,50	proline	keratin 16	CHEBI:26271	3868	Chemical	Gene	mutations|amod|START_ENTITY mutations|nmod|END_ENTITY	Novel proline substitution mutations in keratin_16 in two cases of pachyonychia congenita type 1 .
8210513	0	proline	36,43	neurotensin	21,32	proline	neurotensin	CHEBI:26271	299757(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Inhibitory effect of neurotensin on proline .
21903295	0	proline	108,115	ornithine_amino_transferase	57,84	proline	ornithine amino transferase	CHEBI:26271	4942	Chemical	Gene	contributes|xcomp|START_ENTITY contributes|nsubj|END_ENTITY	Exogenous ornithine is an effective precursor and the - ornithine_amino_transferase pathway contributes to proline accumulation under high N recycling in salt-stressed cashew leaves .
14612423	0	proline	4,11	p53	29,32	proline	p53	CHEBI:26271	7157	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	The proline repeat domain of p53 binds directly to the transcriptional coactivator p300 and allosterically controls DNA-dependent acetylation of p53 .
17172295	0	proline	121,128	prion_protein	147,160	proline	prion protein	CHEBI:26271	5621	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Beta-sheet containment by flanking prolines : molecular dynamic simulations of the inhibition of beta-sheet elongation by proline residues in human prion_protein .
11788754	0	proline	66,73	proline_dehydrogenase	18,39	proline	proline dehydrogenase	CHEBI:26271	822833(Tax:3702)	Chemical	Gene	cause|nmod|START_ENTITY cause|nsubj|levels levels|nmod|END_ENTITY	Altered levels of proline_dehydrogenase cause hypersensitivity to proline and its analogs in Arabidopsis .
12376638	0	proline	39,46	proline_dehydrogenase	116,137	proline	proline dehydrogenase	CHEBI:26271	822833(Tax:3702)	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	ACTCAT , a novel cis-acting element for proline - and hypoosmolarity-responsive expression of the ProDH gene encoding proline_dehydrogenase in Arabidopsis .
12773641	0	proline	17,24	proline_dehydrogenase	85,106	proline	proline dehydrogenase	CHEBI:26271	822833(Tax:3702)	Chemical	Gene	Toxicity|nmod|START_ENTITY revealed|nsubj|Toxicity revealed|nmod|deficient deficient|nmod|END_ENTITY	Toxicity of free proline revealed in an arabidopsis T-DNA-tagged mutant deficient in proline_dehydrogenase .
15065439	0	proline	26,33	proline_dehydrogenase	130,151	proline	proline dehydrogenase	CHEBI:26271	822833(Tax:3702)	Chemical	Gene	pressure|amod|START_ENTITY level|nmod|pressure Increase|nmod|level Increase|nmod|tobacco tobacco|acl|bearing bearing|dobj|suppressor suppressor|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Increase in the level of proline and osmotic pressure of cytoplasm in transformed tobacco bearing an antisense suppressor of the proline_dehydrogenase gene -RSB- .
19140736	0	proline	99,106	proline_dehydrogenase	44,65	proline	proline dehydrogenase	CHEBI:26271	5625	Chemical	Gene	preference|nmod|START_ENTITY enforce|dobj|preference helps|xcomp|enforce helps|nsubj|residue residue|nmod|END_ENTITY	A conserved active site tyrosine residue of proline_dehydrogenase helps enforce the preference for proline over hydroxyproline as the substrate .
8776899	0	proline	121,128	proline_dehydrogenase	38,59	proline	proline dehydrogenase	CHEBI:26271	822833(Tax:3702)	Chemical	Gene	upregulated|nmod|START_ENTITY upregulated|nsubjpass|END_ENTITY	A nuclear gene encoding mitochondrial proline_dehydrogenase , an enzyme involved in proline metabolism , is upregulated by proline but downregulated by dehydration in Arabidopsis .
8776899	0	proline	83,90	proline_dehydrogenase	38,59	proline	proline dehydrogenase	CHEBI:26271	822833(Tax:3702)	Chemical	Gene	metabolism|amod|START_ENTITY involved|nmod|metabolism enzyme|acl|involved END_ENTITY|appos|enzyme	A nuclear gene encoding mitochondrial proline_dehydrogenase , an enzyme involved in proline metabolism , is upregulated by proline but downregulated by dehydration in Arabidopsis .
9847097	0	proline	61,68	proline_dehydrogenase	16,37	proline	proline dehydrogenase	CHEBI:26271	822833(Tax:3702)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	A gene encoding proline_dehydrogenase is not only induced by proline and hypoosmolarity , but is also developmentally regulated in the reproductive organs of Arabidopsis .
17176070	0	proline	45,52	triosephosphate_isomerase	56,81	proline	triosephosphate isomerase	CHEBI:26271	7167	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Functional role of the conserved active site proline of triosephosphate_isomerase .
22955912	0	prolyl	47,53	EPO	79,82	prolyl	EPO	CHEBI:26274	13856(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY production|compound|END_ENTITY	Transmembrane_prolyl 4-hydroxylase is a fourth prolyl 4-hydroxylase regulating EPO production and erythropoiesis .
17353276	0	prolyl	13,19	FKBP38	40,46	prolyl	FKBP38	CHEBI:26274	23770	Chemical	Gene	stability|compound|START_ENTITY stability|compound|END_ENTITY	The peptidyl prolyl cis/trans isomerase FKBP38 determines hypoxia-inducible transcription factor prolyl-4-hydroxylase PHD2 protein stability .
16157596	0	prolyl	96,102	HIF-1alpha	48,58	prolyl	HIF-1alpha	CHEBI:26274	3091	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Suppression of hypoxia-inducible_factor_1alpha -LRB- HIF-1alpha -RRB- transcriptional activity by the HIF prolyl hydroxylase EGLN1 .
12039559	0	prolyl	27,33	PHD1	47,51	prolyl	PHD1	CHEBI:26274	112398	Chemical	Gene	hydroxylase|amod|START_ENTITY hydroxylase|appos|END_ENTITY	The use of dioxygen by HIF prolyl hydroxylase -LRB- PHD1 -RRB- .
16782814	0	prolyl	71,77	PHD2	91,95	prolyl	PHD2	CHEBI:26274	54583	Chemical	Gene	hydroxylase|compound|START_ENTITY hydroxylase|appos|END_ENTITY	Cellular oxygen sensing : Crystal structure of hypoxia-inducible factor prolyl hydroxylase -LRB- PHD2 -RRB- .
17353276	0	prolyl	13,19	PHD2	118,122	prolyl	PHD2	CHEBI:26274	54583	Chemical	Gene	stability|compound|START_ENTITY stability|compound|END_ENTITY	The peptidyl prolyl cis/trans isomerase FKBP38 determines hypoxia-inducible transcription factor prolyl-4-hydroxylase PHD2 protein stability .
25035986	0	prolyl	47,53	Pin1	65,69	prolyl	Pin1	CHEBI:26274	23988(Tax:10090)	Chemical	Gene	isomerase|amod|START_ENTITY isomerase|appos|END_ENTITY	A high-throughput screen for inhibitors of the prolyl isomerase , Pin1 , identifies a seaweed polyphenol that reduces adipose cell differentiation .
16157596	0	prolyl	96,102	hypoxia-inducible_factor_1alpha	15,46	prolyl	hypoxia-inducible factor 1alpha	CHEBI:26274	3091	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Suppression of hypoxia-inducible_factor_1alpha -LRB- HIF-1alpha -RRB- transcriptional activity by the HIF prolyl hydroxylase EGLN1 .
17047048	0	prolyl	117,123	hypoxia-inducible_factor_1alpha	43,74	prolyl	hypoxia-inducible factor 1alpha	CHEBI:26274	3091	Chemical	Gene	hydroxylases|amod|START_ENTITY down-regulation|nmod|hydroxylases END_ENTITY|nmod|down-regulation	EBV latent_membrane_protein_1 up-regulates hypoxia-inducible_factor_1alpha through Siah1-mediated down-regulation of prolyl hydroxylases 1 and 3 in nasopharyngeal epithelial cells .
23305921	0	prolyl_hydroxamic_acid	71,93	tyrosinase	109,119	prolyl hydroxamic acid	tyrosinase	null	7299	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|amod|END_ENTITY	Synthesis and dual biological effects of hydroxycinnamoyl_phenylalanyl / prolyl_hydroxamic_acid derivatives as tyrosinase inhibitor and antioxidant .
4350556	0	promethazine	79,91	ccl_4	45,50	promethazine	ccl 4	MESH:D011398	6351	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nmod|effect	Importance of the route of administration of ccl_4 in the protective effect of promethazine .
21589945	0	propafenone	68,79	P-glycoprotein	99,113	propafenone	P-glycoprotein	MESH:D011405	5243	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Exhaustive sampling of docking poses reveals binding hypotheses for propafenone type inhibitors of P-glycoprotein .
2552989	0	propan-2-ol	10,21	elongation_factor_G	62,81	propan-2-ol	elongation factor G	CHEBI:17824	85476	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of propan-2-ol on enzymic and structural properties of elongation_factor_G .
12638965	0	propane	80,87	VPO	46,49	propane	VPO	MESH:D011407	7837	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of water on the catalytic behaviour of VPO in the selective oxidation of propane to acrylic_acid .
6116801	0	propantheline	36,49	Histamine_H2-receptor	0,21	propantheline	Histamine H2-receptor	MESH:D011413	100135540(Tax:10141)	Chemical	Gene	antagonism|nmod|START_ENTITY antagonism|nsubj|END_ENTITY	Histamine_H2-receptor antagonism by propantheline and derivatives .
2872493	0	propantheline	10,23	growth_hormone	27,41	propantheline	growth hormone	MESH:D011413	2688	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|compound|END_ENTITY	Effect of propantheline on growth_hormone and blood glucose levels .
6683853	0	propantheline_bromide	11,32	growth_hormone	42,56	propantheline bromide	growth hormone	MESH:D011413	2688	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|compound|END_ENTITY	Effects of propantheline_bromide on basal growth_hormone , cortisol and prolactin levels .
23923069	0	propentofylline	24,39	GAP-43	14,20	propentofylline	GAP-43	MESH:C032114	29423(Tax:10116)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of GAP-43 by propentofylline in a rat model of neuropathic_pain .
9062684	0	propentofylline	23,38	NGF	77,80	propentofylline	NGF	MESH:C032114	310738(Tax:10116)	Chemical	Gene	administration|nmod|START_ENTITY administration|appos|END_ENTITY	Oral administration of propentofylline , a stimulator of nerve growth factor -LRB- NGF -RRB- synthesis , recovers cholinergic neuronal_dysfunction induced by the infusion of anti-NGF antibody into the rat septum .
25268938	0	propiconazole	56,69	P-glycoprotein	0,14	propiconazole	P-glycoprotein	MESH:C045950	67078(Tax:10090)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	P-glycoprotein inhibition by the agricultural pesticide propiconazole and its hydroxylated metabolites : Implications for pesticide-drug interactions .
3707613	0	propiolaldehyde	8,23	aldehyde_dehydrogenase	87,109	propiolaldehyde	aldehyde dehydrogenase	MESH:C018132	25375(Tax:10116)	Chemical	Gene	metabolites|amod|START_ENTITY Role|nmod|metabolites END_ENTITY|nsubj|Role	Role of propiolaldehyde and other metabolites in the pargyline inhibition of rat liver aldehyde_dehydrogenase .
705026	0	propiolaldehyde	40,55	aldehyde_dehydrogenase	14,36	propiolaldehyde	aldehyde dehydrogenase	MESH:C018132	25375(Tax:10116)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of aldehyde_dehydrogenase by propiolaldehyde , a possible metabolite of pargyline .
17283404	0	propionate	47,57	Insulin	0,7	propionate	Insulin	CHEBI:17272	280829(Tax:9913)	Chemical	Gene	tests|amod|START_ENTITY patterns|nmod|tests patterns|compound|END_ENTITY	Insulin and glucagon secretory patterns during propionate and arginine tolerance tests in Japanese black cattle with growth_retardation .
7601733	0	propionate	41,51	Plasma_insulin_and_glucagon	0,27	propionate	Plasma insulin and glucagon	CHEBI:17272	443179(Tax:9940)	Chemical	Gene	responses|xcomp|START_ENTITY responses|nsubj|END_ENTITY	Plasma_insulin_and_glucagon responses to propionate infusion into femoral and mesenteric veins in sheep .
7904990	0	propionate	65,75	Plasma_insulin_and_glucagon	0,27	propionate	Plasma insulin and glucagon	CHEBI:17272	443179(Tax:9940)	Chemical	Gene	responses|nmod|START_ENTITY responses|compound|END_ENTITY	Plasma_insulin_and_glucagon responses to intravenous infusion of propionate and their autonomic control in sheep .
6246879	0	propionate	34,44	cytochrome_c	48,60	propionate	cytochrome c	CHEBI:17272	54205	Chemical	Gene	modification|nmod|START_ENTITY modification|nmod|END_ENTITY	Chemical modification of the haem propionate of cytochrome_c .
2205294	0	propionate	40,50	insulin	10,17	propionate	insulin	CHEBI:17272	105613195	Chemical	Gene	utilization|nmod|START_ENTITY Effect|nmod|utilization Effect|nmod|END_ENTITY	Effect of insulin on the utilization of propionate in gluconeogenesis in sheep .
15539315	0	propionate	51,61	tissue_transglutaminase	13,36	propionate	tissue transglutaminase	CHEBI:17272	7052	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|expression expression|amod|END_ENTITY	Induction of tissue_transglutaminase expression by propionate and n-butyrate in colon_cancer cell lines .
3304416	0	propionic_acid	55,69	insulin	18,25	propionic acid	insulin	MESH:C029658	280829(Tax:9913)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects on plasma insulin of intermittent infusions of propionic_acid , glucose or casein into the alimentary tract of non-lactating cows maintained on a liquid diet .
8179938	0	propionyl	41,50	acylase	51,58	propionyl	acylase	CHEBI:26294	95	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	-LSB- Localization and nucleotide sequence of propionyl acylase gene of Streptomyces mycarofaciens -RSB- .
18184179	0	propiverine	27,38	M-1	66,69	propiverine	M-1	MESH:C015586	100507027	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Pharmacological effects of propiverine and its active metabolite , M-1 , on isolated human urinary bladder smooth muscle , and on bladder_contraction in rats .
15008959	0	propofol	10,18	Angiotensin_II	75,89	propofol	Angiotensin II	MESH:D015742	24179(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|acl|induced induced|nmod|END_ENTITY	Effect of propofol on vasoconstriction and calcium mobilization induced by Angiotensin_II differs in aortas from normotensive and hypertensive rats .
25009636	0	propofol	79,87	CCL2	14,18	propofol	CCL2	MESH:D015742	24770(Tax:10116)	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of CCL2 and CCR2 in the hippocampus and the interventional roles of propofol in rat cerebral_ischemia / reperfusion .
21869535	0	propofol	84,92	CYP2B6	108,114	propofol	CYP2B6	MESH:D015742	1555	Chemical	Gene	START_ENTITY|nmod|genotype genotype|compound|END_ENTITY	Individual differences in pharmacokinetics and pharmacodynamics of anesthetic agent propofol with regard to CYP2B6 and UGT1A9 genotype and patient age .
23364923	0	propofol	17,25	HMGB1	8,13	propofol	HMGB1	MESH:D015742	25459(Tax:10116)	Chemical	Gene	protection|amod|START_ENTITY Role|nmod|protection Role|nmod|END_ENTITY	Role of HMGB1 in propofol protection of rat intestinal epithelial cells injured by heat_shock .
25714879	0	propofol	11,19	HMGB1	76,81	propofol	HMGB1	MESH:D015742	15289(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of propofol on lipopolysaccharide-induced expression and release of HMGB1 in macrophages .
26131269	0	propofol	33,41	MAP2K3	61,67	propofol	MAP2K3	MESH:D015742	303200(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|level level|compound|END_ENTITY	Effect of combination therapy of propofol and sevoflurane on MAP2K3 level and myocardial_apoptosis induced by ischemia-reperfusion in rats .
26762997	0	propofol	17,25	MnSOD	8,13	propofol	MnSOD	MESH:D015742	6648	Chemical	Gene	protection|amod|START_ENTITY Role|nmod|protection Role|nmod|END_ENTITY	Role of MnSOD in propofol protection of human umbilical vein endothelial cells injured by heat_stress .
16480469	0	propofol	17,25	P-selectin	29,39	propofol	P-selectin	MESH:D015742	6403	Chemical	Gene	influence|nmod|START_ENTITY influence|nmod|expression expression|amod|END_ENTITY	The influence of propofol on P-selectin expression and nitric_oxide production in re-oxygenated human umbilical vein endothelial cells .
21607877	0	propofol	11,19	P2X7	23,27	propofol	P2X7	MESH:D015742	5027	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|receptors receptors|nummod|END_ENTITY	Effects of propofol on P2X7 receptors and the secretion of tumor_necrosis_factor-a in cultured astrocytes .
22735776	0	propofol	35,43	S100A9	14,20	propofol	S100A9	MESH:D015742	94195(Tax:10116)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|expression expression|compound|END_ENTITY	Inhibition of S100A9 expression by propofol in monocytes of rats with endotoxemia .
23040781	0	propofol	38,46	Toll-like_receptor_4	50,70	propofol	Toll-like receptor 4	MESH:D015742	29260(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	-LSB- The effects of postconditioning with propofol on Toll-like_receptor_4 expression in the lung tissue of rat with acute_lung_injury -RSB- .
17697043	0	propofol	78,86	UDP-glucuronosyltransferase_1A1	34,65	propofol	UDP-glucuronosyltransferase 1A1	MESH:D015742	54658	Chemical	Gene	modulation|nmod|START_ENTITY modulation|nmod|END_ENTITY	Substrate-dependent modulation of UDP-glucuronosyltransferase_1A1 -LRB- UGT1A1 -RRB- by propofol in recombinant human UGT1A1 and human liver microsomes .
17697043	0	propofol	78,86	UGT1A1	67,73	propofol	UGT1A1	MESH:D015742	54658	Chemical	Gene	modulation|nmod|START_ENTITY modulation|appos|END_ENTITY	Substrate-dependent modulation of UDP-glucuronosyltransferase_1A1 -LRB- UGT1A1 -RRB- by propofol in recombinant human UGT1A1 and human liver microsomes .
19752585	0	propofol	20,28	UGT1A6	46,52	propofol	UGT1A6	MESH:D015742	113992(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Pharmacokinetics of propofol and extrahepatic UGT1A6 gene expression in anhepatic rats .
20179014	0	propofol	18,26	alpha	72,77	propofol	alpha	MESH:D015742	146	Chemical	Gene	_|amod|START_ENTITY _|dep|END_ENTITY	Reduced effect of propofol at human -LCB- alpha -RCB- 1 -LCB- beta -RCB- 2 -LRB- N289M -RRB- -LCB- gamma -RCB- 2_and _ -LCB- alpha -RCB- 2 -LCB- beta -RCB- 3 -LRB- N290M -RRB- -LCB- gamma -RCB- 2 mutant GABA -LRB- A -RRB- receptors .
23500137	0	propofol	29,37	apolipoprotein_M	54,70	propofol	apolipoprotein M	MESH:D015742	55937	Chemical	Gene	effects|nmod|START_ENTITY mediated|nsubjpass|effects mediated|nmod|END_ENTITY	Anti-inflammatory effects of propofol are mediated by apolipoprotein_M in a hepatocyte nuclear factor-1a-dependent manner .
23772702	0	propofol	22,30	aquaporin-4	40,51	propofol	aquaporin-4	MESH:D015742	361	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	A general anaesthetic propofol inhibits aquaporin-4 in the presence of Zn .
26100336	0	propofol	11,19	aquaporin-4	39,50	propofol	aquaporin-4	MESH:D015742	361	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effects of propofol and sevoflurane on aquaporin-4 and aquaporin-9 expression in patients performed gliomas resection .
22144767	0	propofol	27,35	c-Fos	66,71	propofol	c-Fos	MESH:D015742	14281(Tax:10090)	Chemical	Gene	administration|nmod|START_ENTITY upregulated|nsubj|administration upregulated|dobj|expression expression|nmod|proteins proteins|amod|END_ENTITY	Repeated administration of propofol upregulated the expression of c-Fos and cleaved-caspase-3 proteins in the developing mouse brain .
20707988	0	propofol	15,23	caspase-3	39,48	propofol	caspase-3	MESH:D015742	25402(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|forebrain_ischemia-reperfusion forebrain_ischemia-reperfusion|amod|END_ENTITY	The effects of propofol on hippocampal caspase-3 and Bcl-2 expression following forebrain_ischemia-reperfusion in rats .
22069482	0	propofol	11,19	caspase-3	54,63	propofol	caspase-3	MESH:D015742	836	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|activation activation|amod|END_ENTITY	Anesthetic propofol attenuates the isoflurane-induced caspase-3 activation and Ab oligomerization .
19104173	0	propofol	11,19	endothelin-1	45,57	propofol	endothelin-1	MESH:D015742	1906	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|amod|END_ENTITY	Effects of propofol on cyclic strain-induced endothelin-1 expression in human umbilical vein endothelial cells .
9477066	0	propofol	22,30	endothelin-1	61,73	propofol	endothelin-1	MESH:D015742	24323(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|acl|signaling signaling|nmod|END_ENTITY	Inhibitory effects of propofol on intracellular signaling by endothelin-1 in aortic smooth muscle cells .
23743186	0	propofol	60,68	glycogen_synthase_kinase_3b	8,35	propofol	glycogen synthase kinase 3b	MESH:D015742	2932	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of glycogen_synthase_kinase_3b in protective effect of propofol against hepatic_ischemia-reperfusion injury .
20039079	0	propofol	27,35	hypoxia-inducible_factor_1	72,98	propofol	hypoxia-inducible factor 1	MESH:D015742	3091	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	The intravenous anesthetic propofol inhibits lipopolysaccharide-induced hypoxia-inducible_factor_1 activation and suppresses the glucose metabolism in macrophages .
23274498	0	propofol	16,24	insulin	33,40	propofol	insulin	MESH:D015742	3630	Chemical	Gene	Anesthesia|nmod|START_ENTITY induces|nsubj|Anesthesia induces|dobj|systemically systemically|compound|END_ENTITY	Anesthesia with propofol induces insulin resistance systemically in skeletal and cardiac muscles and liver of rats .
26170951	0	propofol	39,47	insulin	96,103	propofol	insulin	MESH:D015742	3630	Chemical	Gene	resistance|amod|START_ENTITY resistance|compound|END_ENTITY	Protective effect of pretreatment with propofol against tumor necrosis factor-a-induced hepatic insulin resistance .
19149672	0	propofol	25,33	lactoperoxidase	44,59	propofol	lactoperoxidase	MESH:D015742	280844(Tax:9913)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The inhibitory effect of propofol on bovine lactoperoxidase .
25547709	0	propofol	12,20	miR-181a	24,32	propofol	miR-181a	MESH:D015742	387176(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effects of propofol on miR-181a and Bcl-2 expression in glucose_deprivation cultured astrocytes -RSB- .
16027086	0	propofol	12,20	neuron-specific_enolase	45,68	propofol	neuron-specific enolase	MESH:D015742	2026	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|level level|amod|END_ENTITY	-LSB- Effects of propofol and isoflurane on serum neuron-specific_enolase level in surgical patients with acute craniocerebral_trauma : a comparative study -RSB- .
15657568	0	propofol	5,13	parathyroid_hormone	47,66	propofol	parathyroid hormone	MESH:D015742	5741	Chemical	Gene	anesthesia|amod|START_ENTITY affect|nsubj|anesthesia affect|dobj|levels levels|compound|END_ENTITY	Does propofol anesthesia affect intraoperative parathyroid_hormone levels ?
21455643	0	propofol	11,19	parathyroid_hormone	38,57	propofol	parathyroid hormone	MESH:D015742	5741	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of propofol on intraoperative parathyroid_hormone monitoring in patients with primary_hyperparathyroidism undergoing parathyroidectomy : a randomized control trial .
2683851	0	propofol	98,106	somatomedin_C	48,61	propofol	somatomedin C	MESH:D015742	3479	Chemical	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	-LSB- The behavior of hGH -LRB- human growth_hormone -RRB- and somatomedin_C following anesthesia induction with propofol in comparison with diazepam and thiopental -RSB- .
24067211	0	propofol	11,19	thrombospondin-1	23,39	propofol	thrombospondin-1	MESH:D015742	445442(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effect of propofol on thrombospondin-1 expression in cultured newborn rat cortical astrocytes -RSB- .
19107373	0	propofol	11,19	toll-like_receptor_4	46,66	propofol	toll-like receptor 4	MESH:D015742	21898(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effects of propofol on the mRNA expression of toll-like_receptor_4 in BV-2 cells during mimic ischemia-reperfusion injury in vitro .
21607877	0	propofol	11,19	tumor_necrosis_factor-a	59,82	propofol	tumor necrosis factor-a	MESH:D015742	7124	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of propofol on P2X7 receptors and the secretion of tumor_necrosis_factor-a in cultured astrocytes .
2410671	0	propranolol	35,46	ACAT	101,105	propranolol	ACAT	MESH:D011433	100009537(Tax:9986)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effects of antihypertensive agents propranolol , metoprolol , nadolol , prazosin , and chlorthalidone on ACAT activity in rabbit and rat aortas and on LCAT activity in human plasma in vitro .
2527473	0	propranolol	11,22	ANP	46,49	propranolol	ANP	MESH:D011433	4878	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of propranolol and pindolol on plasma ANP levels in humans at rest and during exercise .
6264899	0	propranolol	119,130	Cyclic_nucleotide_phosphodiesterase	0,35	propranolol	Cyclic nucleotide phosphodiesterase	MESH:D011433	50678(Tax:10116)	Chemical	Gene	variation|nmod|START_ENTITY END_ENTITY|dep|variation	Cyclic_nucleotide_phosphodiesterase in the aorta of spontaneously hypertensive rats : variation with age and effect of propranolol .
1553429	0	propranolol	10,21	GHRH	74,78	propranolol	GHRH	MESH:D011433	485863(Tax:9615)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of propranolol on growth_hormone response to GH_releasing_hormone -LRB- GHRH 1-44 -RRB- in the dog .
1553429	0	propranolol	10,21	GH_releasing_hormone	52,72	propranolol	GH releasing hormone	MESH:D011433	485863(Tax:9615)	Chemical	Gene	START_ENTITY|nmod|response response|nmod|END_ENTITY	Effect of propranolol on growth_hormone response to GH_releasing_hormone -LRB- GHRH 1-44 -RRB- in the dog .
3031716	0	propranolol	43,54	Growth_hormone	163,177	propranolol	Growth hormone	MESH:D011433	2688	Chemical	Gene	methysergide|appos|START_ENTITY blockers|dep|methysergide Effect|nmod|blockers Effect|dep|END_ENTITY	Effect of receptor blockers -LRB- methysergide , propranolol , phentolamine , yohimbine and prazosin -RRB- on desimipramine-induced pituitary hormone stimulation in humans -- I. Growth_hormone .
628352	0	propranolol	27,38	Growth_hormone	0,14	propranolol	Growth hormone	MESH:D011433	2688	Chemical	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Growth_hormone response to propranolol and L -- dopa in obese subjects .
6548729	0	propranolol	47,58	LCAT	62,66	propranolol	LCAT	MESH:D011433	3931	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	Effect of talinolol and the optical isomers of propranolol on LCAT activity in vitro .
764929	0	propranolol	36,47	Renin	0,5	propranolol	Renin	MESH:D011433	5972	Chemical	Gene	concentrations|nmod|START_ENTITY concentrations|amod|END_ENTITY	Renin concentrations and effects of propranolol and spironolactone in patients with hypertension .
772425	0	propranolol	62,73	Renin	0,5	propranolol	Renin	MESH:D011433	5972	Chemical	Gene	treatment|nmod|START_ENTITY profiling|nmod|treatment END_ENTITY|acl|profiling	Renin profiling in hypertension and its use in treatment with propranolol and chlorthalidone .
6133659	0	propranolol	21,32	T3	88,90	propranolol	T3	MESH:D011433	24754(Tax:10116)	Chemical	Gene	effects|acl|START_ENTITY effects|nmod|END_ENTITY	Different effects of propranolol , alprenolol , sotalol , atenolol and metoprolol on serum T3 and serum rT3 in hyperthyroidism .
241811	0	propranolol	84,95	Tyrosine_hydroxylase	0,20	propranolol	Tyrosine hydroxylase	MESH:D011433	25085(Tax:10116)	Chemical	Gene	activity|dep|START_ENTITY activity|amod|END_ENTITY	Tyrosine_hydroxylase activity in rat brain regions after chronic treatment with + / -- propranolol .
26622443	0	propranolol	21,32	VEGF	85,89	propranolol	VEGF	MESH:D011433	7422	Chemical	Gene	efficacy|nmod|START_ENTITY efficacy|nmod|END_ENTITY	Clinical efficacy of propranolol in the treatment of hemangioma and changes in serum VEGF , bFGF and MMP-9 .
26665926	0	propranolol	11,22	VEGF	37,41	propranolol	VEGF	MESH:D011433	7422	Chemical	Gene	Effect|nmod|START_ENTITY gel|nsubj|Effect gel|nmod|END_ENTITY	-LSB- Effect of propranolol gel on plasma VEGF , bFGF and MMP-9 in proliferating infantile_hemangiomas of superficial type -RSB- .
26109805	0	propranolol	58,69	b-2_Adrenergic_receptor	0,23	propranolol	b-2 Adrenergic receptor	MESH:D011433	154	Chemical	Gene	START_ENTITY|nsubj|polymorphism polymorphism|amod|END_ENTITY	b-2_Adrenergic_receptor gene polymorphism and response to propranolol in cirrhosis .
2439825	0	propranolol	10,21	beta_2-adrenoceptor	63,82	propranolol	beta 2-adrenoceptor	MESH:D011433	154	Chemical	Gene	START_ENTITY|nmod|density density|amod|END_ENTITY	Effect of propranolol , alprenolol , pindolol , and bopindolol on beta_2-adrenoceptor density in human lymphocytes .
2103752	0	propranolol	10,21	gastrin	42,49	propranolol	gastrin	MESH:D011433	2520	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|release release|compound|END_ENTITY	Effect of propranolol on secretin-induced gastrin release and secretin-induced tachycardia in patients with the Zollinger-Ellison_syndrome .
241651	0	propranolol	14,25	gastrin	52,59	propranolol	gastrin	MESH:D011433	2520	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|concentration concentration|compound|END_ENTITY	The effect of propranolol and phentolamine on serum gastrin concentration in response to respiratory_acidosis in normal man .
4133478	0	propranolol	70,81	growth-hormone	40,54	propranolol	growth-hormone	MESH:D011433	2688	Chemical	Gene	stimulation|nmod|START_ENTITY stimulation|amod|END_ENTITY	Letter : Enhancement of levodopa-induced growth-hormone stimulation by propranolol .
1553429	0	propranolol	10,21	growth_hormone	25,39	propranolol	growth hormone	MESH:D011433	403795(Tax:9615)	Chemical	Gene	START_ENTITY|nmod|response response|amod|END_ENTITY	Effect of propranolol on growth_hormone response to GH_releasing_hormone -LRB- GHRH 1-44 -RRB- in the dog .
451694	0	propranolol	25,36	growth_hormone	41,55	propranolol	growth hormone	MESH:D011433	2688	Chemical	Gene	START_ENTITY|nmod|provocation provocation|amod|END_ENTITY	Combined oral L-dopa and propranolol for growth_hormone provocation .
1124146	0	propranolol	12,23	insulin	63,70	propranolol	insulin	MESH:D011433	3630	Chemical	Gene	Effects|nmod|START_ENTITY induced|nsubj|Effects induced|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Effects of propranolol on some metabolic changes induced with insulin -RSB- .
2694115	0	propranolol	11,22	insulin	51,58	propranolol	insulin	MESH:D011433	3630	Chemical	Gene	therapy|amod|START_ENTITY Effect|nmod|therapy Effect|nmod|secretion secretion|nmod|END_ENTITY	-LSB- Effect of propranolol therapy on the secretion of insulin , glucagon , gastrin and pancreatic_polypeptide in patients with essential hypertension -RSB- .
2857210	0	propranolol	15,26	insulin	118,125	propranolol	insulin	MESH:D011433	3630	Chemical	Gene	Aggravation|nmod|START_ENTITY Aggravation|nmod|alteration alteration|nmod|secretion secretion|compound|END_ENTITY	Aggravation by propranolol of hyperglycaemic effect of hydrochlorothiazide in type II diabetics without alteration of insulin secretion .
6468493	0	propranolol	35,46	insulin	75,82	propranolol	insulin	MESH:D011433	100009181(Tax:9986)	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	Adrenal function and the action of propranolol in surgical stress-mediated insulin resistance of glucose utilization by peripheral tissues in vivo .
24364277	0	propranolol	11,22	myoglobin	36,45	propranolol	myoglobin	MESH:D011433	59108(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	-LSB- Effect of propranolol on dialysate myoglobin levels evoked by ischemia/reperfusion -RSB- .
18588611	0	propranolol	67,78	oxytocin	35,43	propranolol	oxytocin	MESH:D011433	5020	Chemical	Gene	START_ENTITY|nsubj|comparison comparison|nmod|effect effect|nmod|END_ENTITY	A comparison between the effect of oxytocin only and oxytocin plus propranolol on the labor -LRB- a double blind randomized trial -RRB- .
24392402	0	propranolol	26,37	oxytocin	58,66	propranolol	oxytocin	MESH:D011433	5020	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Comparison effect of oral propranolol and oxytocin versus oxytocin only on induction of labour in nulliparous women -LRB- a double blind randomized trial -RRB- .
8185671	0	propranolol	40,51	phospholipase_D	55,70	propranolol	phospholipase D	MESH:D011433	2822	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Sphingosine-like stimulatory effects of propranolol on phospholipase_D activity in NIH 3T3 fibroblasts .
6624970	0	propranolol	7,18	rage	59,63	propranolol	rage	MESH:D011433	101669765	Chemical	Gene	Use|nmod|START_ENTITY Use|nmod|END_ENTITY	Use of propranolol for provoked and unprovoked episodes of rage .
1071618	0	propranolol	39,50	renin	21,26	propranolol	renin	MESH:D011433	5972	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	The immediate plasma renin response to propranolol : evidence for a different mode of renin release in essential and renal_hypertension .
1071618	0	propranolol	39,50	renin	85,90	propranolol	renin	MESH:D011433	5972	Chemical	Gene	response|nmod|START_ENTITY response|dep|evidence evidence|nmod|mode mode|nmod|release release|compound|END_ENTITY	The immediate plasma renin response to propranolol : evidence for a different mode of renin release in essential and renal_hypertension .
1071960	0	propranolol	73,84	renin	7,12	propranolol	renin	MESH:D011433	5972	Chemical	Gene	treatment|nmod|START_ENTITY END_ENTITY|nmod|treatment	Plasma renin activity and blood pressure during long term treatment with propranolol and diuretic .
10725	0	propranolol	114,125	renin	37,42	propranolol	renin	MESH:D011433	5972	Chemical	Gene	concentration|nmod|START_ENTITY concentration|nsubj|Effect Effect|nmod|depletion depletion|nmod|END_ENTITY	Effect of sodium depletion on plasma renin concentration before and during adrenergic beta-receptor blockade with propranolol in normotensive man .
10730	0	propranolol	157,168	renin	56,61	propranolol	renin	MESH:D011433	5972	Chemical	Gene	drugs|nmod|START_ENTITY role|nmod|drugs system|dep|role system|acl|treating treating|advcl|profiling profiling|compound|END_ENTITY	Modern system for treating high_blood_pressure based on renin profiling and vasoconstriction-volume analysis : a primary role for beta blocking drugs such as propranolol .
1177407	0	propranolol	51,62	renin	30,35	propranolol	renin	MESH:D011433	5972	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	-LSB- Different reaction of plasma renin activity after propranolol in essential and renal_hypertension -RSB- .
1208570	0	propranolol	10,21	renin	32,37	propranolol	renin	MESH:D011433	24715(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Effect of propranolol on plasma renin activity , renal cortex renin , and adrenal and brain isorenins in rats .
1241067	0	propranolol	10,21	renin	39,44	propranolol	renin	MESH:D011433	5972	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of propranolol and prindolol on renin secretion in normal supine man .
1276834	0	propranolol	35,46	renin	17,22	propranolol	renin	MESH:D011433	5972	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Immediate plasma renin response to propranolol : differentiation between essential and renal_hypertension .
175422	0	propranolol	18,29	renin	72,77	propranolol	renin	MESH:D011433	5972	Chemical	Gene	influence|nmod|START_ENTITY -LSB-|dobj|influence -LSB-|nmod|activity activity|compound|END_ENTITY	-LSB- The influence of propranolol , practolol and theophylline on the plasma renin activity -LRB- author 's transl -RRB- -RSB- .
191300	0	propranolol	87,98	renin	12,17	propranolol	renin	MESH:D011433	5972	Chemical	Gene	blockade|amod|START_ENTITY comparison|nmod|blockade Blockade|dep|comparison Blockade|nmod|END_ENTITY	Blockade of renin or angiotensin for understanding human hypertension : a comparison of propranolol , saralasin and converting enzyme blockade .
26489635	0	propranolol	18,29	renin	44,49	propranolol	renin	MESH:D011433	5972	Chemical	Gene	Effect|nmod|START_ENTITY gel|nsubj|Effect gel|nmod|END_ENTITY	Effect of topical propranolol gel on plasma renin , angiotensin_ii and vascular_endothelial_growth_factor in superficial infantile_hemangiomas .
4155994	0	propranolol	29,40	renin	71,76	propranolol	renin	MESH:D011433	5972	Chemical	Gene	Comparison|nmod|START_ENTITY Comparison|acl|blocking blocking|dobj|END_ENTITY	Comparison of the effects of propranolol and ICI_66082 in blocking the renin releasing effect of renal nerve stimulation in the cat .
6358580	0	propranolol	69,80	renin	51,56	propranolol	renin	MESH:D011433	24715(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Inhibition of captopril-induced increase in plasma renin activity by propranolol .
6397501	0	propranolol	71,82	renin	23,28	propranolol	renin	MESH:D011433	24715(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY activity|dep|effects activity|compound|END_ENTITY	Aldosterone and plasma renin activity in hyperthyroid rats : effects of propranolol and propylthiouracil .
6764167	0	propranolol	11,22	renin	46,51	propranolol	renin	MESH:D011433	5972	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|compound|END_ENTITY	Effects of propranolol and atenolol on plasma renin activity and systolic time intervals in borderline hypertension .
6996018	0	propranolol	10,21	renin	77,82	propranolol	renin	MESH:D011433	5972	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|excretion excretion|nmod|activity activity|compound|END_ENTITY	Effect of propranolol on the urinary excretion of prostaglandin_E and plasma renin activity in hypertensive patients .
6996661	0	propranolol	10,21	renin	29,34	propranolol	renin	MESH:D011433	5972	Chemical	Gene	START_ENTITY|nmod|response response|compound|END_ENTITY	Effect of propranolol on the renin response to frusemide in man .
7032826	0	propranolol	26,37	renin	96,101	propranolol	renin	MESH:D011433	5972	Chemical	Gene	effect|nmod|START_ENTITY involve|nsubj|effect involve|ccomp|aldosterone aldosterone|nsubj|END_ENTITY	The hypotensive effect of propranolol in captopril-treated patients does not involve the plasma renin -- angiotensin -- aldosterone system .
7039349	8	propranolol	1048,1059	renin	926,931	propranolol	renin	MESH:D011433	5972	Chemical	Gene	administration|amod|START_ENTITY present|nmod|administration increased|parataxis|present increased|dobj|release release|compound|END_ENTITY	Intrarenal infusion of glucagon and dopamine increased renin release by 13 + / - 3 and 22 + / - 12 micrograms/min , respectively ; enhancement of renin release was also present after propranolol administration .
843147	0	propranolol	40,51	renin	23,28	propranolol	renin	MESH:D011433	5972	Chemical	Gene	effects|nmod|START_ENTITY effects|compound|END_ENTITY	Hemodynamic and plasma renin effects of propranolol in essential hypertension .
870747	0	propranolol	68,79	renin	21,26	propranolol	renin	MESH:D011433	5972	Chemical	Gene	-RSB-|amod|START_ENTITY Behaviour|nmod|-RSB- Behaviour|nmod|activity activity|compound|END_ENTITY	-LSB- Behaviour of plasma renin activity during long-term treatment with propranolol -LRB- author 's transl -RRB- -RSB- .
879001	0	propranolol	61,72	renin	16,21	propranolol	renin	MESH:D011433	5972	Chemical	Gene	therapy|amod|START_ENTITY changes|nmod|therapy changes|nsubj|activity activity|dep|END_ENTITY	Blood pressure , renin activity and heart rate changes during propranolol therapy of hypertension .
9547558	0	propranolol	15,26	thrombin	63,71	propranolol	thrombin	MESH:D011433	2147	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Dual effect of propranolol on the human platelet activation by thrombin : potentiation of free intracellular Ca2 + mobilization and inhibition of phospholipase D activity .
189996	0	propranolol	17,28	thyrotropin_receptor	36,56	propranolol	thyrotropin receptor	MESH:D011433	7253	Chemical	Gene	influence|nmod|START_ENTITY influence|nmod|END_ENTITY	The influence of propranolol on the thyrotropin_receptor .
6466702	0	propranolol	10,21	tryptophan_oxygenase	81,101	propranolol	tryptophan oxygenase	MESH:D011433	64206(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of propranolol and cycloheximide on the ethanol-induced increase in liver tryptophan_oxygenase activity in starved rats .
23180813	0	propranolol	109,120	tumour_necrosis_factor-a	136,160	propranolol	tumour necrosis factor-a	MESH:D011433	24835(Tax:10116)	Chemical	Gene	stimulation|amod|START_ENTITY stimulation|nmod|production production|amod|END_ENTITY	Adrenal_hormone_deprivation affects macrophage catecholamine metabolism and b2-adrenoceptor density , but not propranolol stimulation of tumour_necrosis_factor-a production .
11489433	0	propranolol_glycol	144,162	monoamine_oxidase	53,70	propranolol glycol	monoamine oxidase	MESH:C013223	29253(Tax:10116)	Chemical	Gene	involvement|acl|START_ENTITY involvement|nmod|END_ENTITY	Side-chain metabolism of propranolol : involvement of monoamine_oxidase and aldehyde_reductase in the metabolism of N-desisopropylpropranolol to propranolol_glycol in rat liver .
14628447	0	propylene_glycol_mannate_sulfate	40,72	MCP-1	15,20	propylene glycol mannate sulfate	MCP-1	null	24770(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	-LSB- Inhibition of MCP-1 mRNA expression by propylene_glycol_mannate_sulfate in hyperlipidemic rat aorta -RSB- .
17070108	0	propylthiouracil	61,77	MPO	53,56	propylthiouracil	MPO	MESH:D011441	4353	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of oxidation activity of myeloperoxidase -LRB- MPO -RRB- by propylthiouracil -LRB- PTU -RRB- and anti-MPO antibodies from patients with PTU-induced vasculitis .
11422030	0	propylthiouracil	10,26	adenosine_deaminase	30,49	propylthiouracil	adenosine deaminase	MESH:D011441	100	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effect of propylthiouracil on adenosine_deaminase activity and thyroid function in patients with psoriasis .
2159305	0	propylthiouracil	48,64	myeloperoxidase	29,44	propylthiouracil	myeloperoxidase	MESH:D011441	303413(Tax:10116)	Chemical	Gene	Mechanism|nmod|START_ENTITY Mechanism|nmod|END_ENTITY	Mechanism of inactivation of myeloperoxidase by propylthiouracil .
21820424	0	propylthiouracil	21,37	prolactin	59,68	propylthiouracil	prolactin	MESH:D011441	5617	Chemical	Gene	efficacy|nmod|START_ENTITY efficacy|nmod|END_ENTITY	Clinical efficacy of propylthiouracil and its influence on prolactin in psoriatic patients .
20924043	0	propylthiouracil	23,39	steroidogenic_acute_regulatory_protein	91,129	propylthiouracil	steroidogenic acute regulatory protein	MESH:D011441	25557(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|compound|END_ENTITY	Stimulatory effects of propylthiouracil on pregnenolone production through upregulation of steroidogenic_acute_regulatory_protein expression in rat granulosa cells .
7355663	0	propylthiouracil	11,27	thyroglobulin	59,72	propylthiouracil	thyroglobulin	MESH:D011441	24826(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|synthesis synthesis|compound|END_ENTITY	Effects of propylthiouracil and methylmercaptoimidazole on thyroglobulin synthesis .
7999027	0	prosomatostatin	20,35	S-28	53,57	prosomatostatin	S-28	MESH:C028456	6750	Chemical	Gene	START_ENTITY|nmod|cells cells|amod|END_ENTITY	Processing of human prosomatostatin in AtT-20 cells : S-28 and S-14 are generated in different secretory pathways .
6109991	0	prosomatostatin	11,26	growth_hormone	30,44	prosomatostatin	growth hormone	MESH:C028456	2688	Chemical	Gene	START_ENTITY|nmod|response response|compound|END_ENTITY	Effects of prosomatostatin on growth_hormone and prolactin response to arginine in man .
20019327	0	prostacyclin	59,71	Brain-derived_neurotrophic_factor	0,33	prostacyclin	Brain-derived neurotrophic factor	MESH:D011464	100356949(Tax:9986)	Chemical	Gene	production|nmod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor stimulates production of prostacyclin in cerebral arteries .
18838483	0	prostacyclin	26,38	COX-1	17,22	prostacyclin	COX-1	MESH:D011464	4512	Chemical	Gene	production|compound|START_ENTITY role|nmod|production role|nmod|END_ENTITY	Critical role of COX-1 in prostacyclin production by human endothelial cells under modification of hydroperoxide tone .
11509629	0	prostacyclin	122,134	COX-2	148,153	prostacyclin	COX-2	MESH:D011464	4513	Chemical	Gene	synthesis|compound|START_ENTITY synthesis|nmod|END_ENTITY	Roles of cyclooxygenase _ -LRB- COX -RRB- -1 and COX-2 in prostanoid production by human endothelial cells : selective up-regulation of prostacyclin synthesis by COX-2 .
2473289	0	prostacyclin	22,34	Endothelin-1	0,12	prostacyclin	Endothelin-1	MESH:D011464	100009270(Tax:9986)	Chemical	Gene	releases|dobj|START_ENTITY releases|nsubj|END_ENTITY	Endothelin-1 releases prostacyclin and inhibits ex vivo platelet_aggregation in the anesthetized rabbit .
1725311	0	prostacyclin	24,36	Endothelin-3	0,12	prostacyclin	Endothelin-3	MESH:D011464	513753(Tax:9913)	Chemical	Gene	production|compound|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Endothelin-3 stimulates prostacyclin production in cultured bovine endothelial cells .
3056398	0	prostacyclin	49,61	IL-1	20,24	prostacyclin	IL-1	MESH:D011464	3552	Chemical	Gene	synthesis|compound|START_ENTITY effects|nmod|synthesis effects|nmod|END_ENTITY	Additive effects of IL-1 and TNF on induction of prostacyclin synthesis in human vascular endothelial cells .
2127553	0	prostacyclin	55,67	Interleukin-1	0,13	prostacyclin	Interleukin-1	MESH:D011464	3552	Chemical	Gene	release|nmod|START_ENTITY potentiates|dobj|release potentiates|nsubj|END_ENTITY	Interleukin-1 potentiates histamine-induced release of prostacyclin from human endothelial cells .
10622468	0	prostacyclin	35,47	Interleukin-8	0,13	prostacyclin	Interleukin-8	MESH:D011464	3576	Chemical	Gene	production|compound|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Interleukin-8 stimulates placental prostacyclin production in preeclampsia .
24954635	0	prostacyclin	31,43	PTGIR	54,59	prostacyclin	PTGIR	MESH:D011464	5739	Chemical	Gene	receptor|compound|START_ENTITY profile|nmod|receptor profile|appos|END_ENTITY	Expression profile and role of prostacyclin receptor -LRB- PTGIR -RRB- in peri-implantation porcine conceptuses .
16007128	0	prostacyclin	24,36	PTGIS	47,52	prostacyclin	PTGIS	MESH:D011464	5740	Chemical	Gene	promoter|compound|START_ENTITY promoter|appos|END_ENTITY	Hypermethylation of the prostacyclin synthase -LRB- PTGIS -RRB- promoter is a frequent event in colorectal_cancer and associated with aneuploidy .
18502100	0	prostacyclin	171,183	TPalpha	150,157	prostacyclin	TPalpha	MESH:D011464	5327	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Differential regulation of RhoA-mediated signaling by the TPalpha and TPbeta isoforms of the human thromboxane_A2_receptor : independent modulation of TPalpha signaling by prostacyclin and nitric_oxide .
11729726	0	prostacyclin	37,49	adrenomedullin	60,74	prostacyclin	adrenomedullin	MESH:D011464	133	Chemical	Gene	treatment|nmod|START_ENTITY Effects|nmod|treatment Effects|nmod|END_ENTITY	-LSB- Effects of long-term treatment with prostacyclin on plasma adrenomedullin in patients with primary_pulmonary_hypertension -RSB- .
1910117	0	prostacyclin	29,41	albumin	12,19	prostacyclin	albumin	MESH:D011464	280717(Tax:9913)	Chemical	Gene	production|compound|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Human serum albumin inhibits prostacyclin production by endothelial cells : the relation of the inhibitory activity to sulfhydryl groups in albumin .
1910117	0	prostacyclin	29,41	albumin	139,146	prostacyclin	albumin	MESH:D011464	280717(Tax:9913)	Chemical	Gene	production|compound|START_ENTITY inhibits|dobj|production inhibits|advcl|sulfhydryl sulfhydryl|nmod|END_ENTITY	Human serum albumin inhibits prostacyclin production by endothelial cells : the relation of the inhibitory activity to sulfhydryl groups in albumin .
6196567	0	prostacyclin	23,35	bradykinin	47,57	prostacyclin	bradykinin	MESH:D011464	478666(Tax:9615)	Chemical	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Pericardial release of prostacyclin induced by bradykinin and angiotensin II : effects on coronary blood flow in the dog .
9822642	0	prostacyclin	29,41	coupling_factor_6	55,72	prostacyclin	coupling factor 6	MESH:D011464	94271(Tax:10116)	Chemical	Gene	synthesis|compound|START_ENTITY synthesis|nmod|END_ENTITY	A novel inhibitory effect on prostacyclin synthesis of coupling_factor_6 extracted from the heart of spontaneously hypertensive rats .
14670842	0	prostacyclin	161,173	cyclooxygenase-2	208,224	prostacyclin	cyclooxygenase-2	MESH:D011464	5743	Chemical	Gene	START_ENTITY|nmod|induction induction|amod|END_ENTITY	Interleukin-1beta , transforming_growth_factor-beta1 , and bradykinin attenuate cyclic_AMP production by human pulmonary artery smooth muscle cells in response to prostacyclin analogues and prostaglandin_E2 by cyclooxygenase-2 induction and downregulation of adenylyl cyclase isoforms 1 , 2 , and 4 .
8321913	0	prostacyclin	38,50	endothelial_cell_growth_factor	65,95	prostacyclin	endothelial cell growth factor	MESH:D011464	2246	Chemical	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Augmentation of interleukin-1 induced prostacyclin production by endothelial_cell_growth_factor : implications for chronic synovitis .
1725337	0	prostacyclin	81,93	endothelin-1	43,55	prostacyclin	endothelin-1	MESH:D011464	403424(Tax:9615)	Chemical	Gene	role|nmod|START_ENTITY effects|dep|role effects|nmod|END_ENTITY	Antiaggregatory and hypotensive effects of endothelin-1 in beagle_dogs : role for prostacyclin .
11788351	0	prostacyclin	61,73	iNOS	24,28	prostacyclin	iNOS	MESH:D011464	4843	Chemical	Gene	synthase|compound|START_ENTITY END_ENTITY|nmod|synthase	Peroxynitrite increases iNOS through NF-kappaB and decreases prostacyclin synthase in endothelial cells .
20522807	0	prostacyclin	56,68	id1	49,52	prostacyclin	id1	MESH:D011464	3397	Chemical	Gene	analogues|compound|START_ENTITY END_ENTITY|nmod|analogues	Smad-dependent and smad-independent induction of id1 by prostacyclin analogues inhibits proliferation of pulmonary artery smooth muscle cells in vitro and in vivo .
17885093	0	prostacyclin	80,92	inducible_nitric-oxide_synthase	4,35	prostacyclin	inducible nitric-oxide synthase	MESH:D011464	18126(Tax:10090)	Chemical	Gene	release|nmod|START_ENTITY modulates|dobj|release modulates|nsubj|END_ENTITY	The inducible_nitric-oxide_synthase modulates endothelin-1-dependent release of prostacyclin and inhibition of platelet_aggregation ex vivo in the mouse .
8321913	0	prostacyclin	38,50	interleukin-1	16,29	prostacyclin	interleukin-1	MESH:D011464	3552	Chemical	Gene	production|compound|START_ENTITY production|amod|END_ENTITY	Augmentation of interleukin-1 induced prostacyclin production by endothelial_cell_growth_factor : implications for chronic synovitis .
2961007	0	prostacyclin	40,52	lipocortin_1	18,30	prostacyclin	lipocortin 1	MESH:D011464	301	Chemical	Gene	production|compound|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Human recombinant lipocortin_1 inhibits prostacyclin production by human umbilical artery in vitro .
17123841	0	prostacyclin	65,77	mPGES1	136,142	prostacyclin	mPGES1	MESH:D011464	64292(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|dep|effects effects|nmod|END_ENTITY	BCP crystals increase prostacyclin production and upregulate the prostacyclin receptor in OA synovial fibroblasts : potential effects on mPGES1 and MMP-13 .
9276148	0	prostacyclin	58,70	neuropeptide_Y	10,24	prostacyclin	neuropeptide Y	MESH:D011464	100724008	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of neuropeptide_Y on bradykinin-induced release of prostacyclin and thromboxane from guinea_pig perfused lung .
6117930	0	prostacyclin	15,27	prolactin	38,47	prostacyclin	prolactin	MESH:D011464	24683(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|secretion secretion|compound|END_ENTITY	The effects of prostacyclin -LRB- PGI2 -RRB- on prolactin secretion in vitro .
18162607	0	prostacyclin	74,86	protease-activated_receptor-1	30,59	prostacyclin	protease-activated receptor-1	MESH:D011464	2149	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|expression expression|amod|END_ENTITY	Transcriptional inhibition of protease-activated_receptor-1 expression by prostacyclin in human vascular smooth_muscle_cells .
15550787	0	prostacyclin	50,62	renin	81,86	prostacyclin	renin	MESH:D011464	403838(Tax:9615)	Chemical	Gene	START_ENTITY|nmod|control control|nmod|release release|compound|END_ENTITY	The differential role of exogenous and endogenous prostacyclin in the control of renin release from dog renal cortical slices .
1839873	0	prostacyclin	102,114	renin	70,75	prostacyclin	renin	MESH:D011464	5972	Chemical	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Maternal and fetal atrial natriuretic peptide levels , maternal plasma renin activity , angiotensin_II , prostacyclin and thromboxane_A2 levels in normal and preeclamptic pregnancies .
6761534	0	prostacyclin	10,22	renin	55,60	prostacyclin	renin	MESH:D011464	5972	Chemical	Gene	infusion|compound|START_ENTITY infusion|nmod|END_ENTITY	Effect of prostacyclin infusion on active and inactive renin release in the isolated perfused kidney .
1371536	0	prostacyclin	81,93	tumor_necrosis_factor	43,64	prostacyclin	tumor necrosis factor	MESH:D011464	21926(Tax:10090)	Chemical	Gene	analogue|compound|START_ENTITY END_ENTITY|nmod|analogue	Inhibition of endotoxin-induced macrophage tumor_necrosis_factor expression by a prostacyclin analogue and its beneficial effect in experimental lipopolysaccharide intoxication .
1648387	0	prostacyclin	36,48	tumor_necrosis_factor	11,32	prostacyclin	tumor necrosis factor	MESH:D011464	7124	Chemical	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	Effects of tumor_necrosis_factor on prostacyclin production and the barrier function of human endothelial cell monolayers .
1869846	0	prostacyclin	45,57	tumor_necrosis_factor	90,111	prostacyclin	tumor necrosis factor	MESH:D011464	7124	Chemical	Gene	dynamics|nmod|START_ENTITY Comparison|nmod|dynamics release|nsubj|Comparison release|nmod|administration administration|nmod|END_ENTITY	Comparison of the early dynamics of systemic prostacyclin release after administration of tumor_necrosis_factor and endotoxin to healthy humans .
1138377	0	prostaglandin	30,43	Angiotensin_II	0,14	prostaglandin	Angiotensin II	CHEBI:26333	183	Chemical	Gene	production|compound|START_ENTITY stimulation|nmod|production stimulation|compound|END_ENTITY	Angiotensin_II stimulation of prostaglandin production in cultured human vascular endothelium .
17328065	0	prostaglandin	40,53	Bradykinin	0,10	prostaglandin	Bradykinin	CHEBI:26333	3827	Chemical	Gene	biosynthesis|compound|START_ENTITY potentiates|dobj|biosynthesis potentiates|nsubj|END_ENTITY	Bradykinin potentiates cytokine-induced prostaglandin biosynthesis in osteoblasts by enhanced expression of cyclooxygenase_2 , resulting in increased RANKL expression .
18587	0	prostaglandin	46,59	Bradykinin	0,10	prostaglandin	Bradykinin	CHEBI:26333	3827	Chemical	Gene	production|compound|START_ENTITY contracted|nmod|production contracted|nsubj|relaxes relaxes|compound|END_ENTITY	Bradykinin relaxes contracted airways through prostaglandin production .
22960173	0	prostaglandin	52,65	CFTR	23,27	prostaglandin	CFTR	CHEBI:26333	100381094(Tax:8355)	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	Lubiprostone activates CFTR , but not ClC-2 , via the prostaglandin receptor -LRB- EP -LRB- 4 -RRB- -RRB- .
11032096	0	prostaglandin	5,18	COX-2	43,48	prostaglandin	COX-2	CHEBI:26333	4513	Chemical	Gene	replacement|compound|START_ENTITY replacement|nmod|inhibition inhibition|compound|END_ENTITY	From prostaglandin replacement to specific COX-2 inhibition : a critical appraisal .
12578976	0	prostaglandin	24,37	COX-2	102,107	prostaglandin	COX-2	CHEBI:26333	4513	Chemical	Gene	effects|nmod|START_ENTITY derived|nsubj|effects derived|nmod|secretion secretion|amod|omega-6_and_omega-3_polyunsaturated_fatty_acids omega-6_and_omega-3_polyunsaturated_fatty_acids|nmod|expression expression|compound|END_ENTITY	Differential effects of prostaglandin derived from omega-6_and_omega-3_polyunsaturated_fatty_acids on COX-2 expression and IL-6 secretion .
14980657	0	prostaglandin	58,71	COX-2	42,47	prostaglandin	COX-2	CHEBI:26333	17709(Tax:10090)	Chemical	Gene	production|compound|START_ENTITY catalyzed|dobj|production catalyzed|nsubj|Synthesis Synthesis|nmod|END_ENTITY	Synthesis and inhibitory activity against COX-2 catalyzed prostaglandin production of chrysin derivatives .
15883739	0	prostaglandin	52,65	COX-2	32,37	prostaglandin	COX-2	CHEBI:26333	17709(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Positive feedback regulation of COX-2 expression by prostaglandin metabolites .
17253252	0	prostaglandin	80,93	COX-2	64,69	prostaglandin	COX-2	CHEBI:26333	4513	Chemical	Gene	biosynthesis|compound|START_ENTITY catalysed|dobj|biosynthesis catalysed|nsubj|END_ENTITY	Amentoflavone from Biophytum sensitivum and its effect on COX-1 / COX-2 catalysed prostaglandin biosynthesis .
19667156	0	prostaglandin	14,27	COX-2	49,54	prostaglandin	COX-2	CHEBI:26333	5743	Chemical	Gene	Expression|nmod|START_ENTITY Expression|acl|metabolising metabolising|dobj|END_ENTITY	Expression of prostaglandin metabolising enzymes COX-2 and 15-PGDH and VDR in human granulosa cells .
22347460	8	prostaglandin	1797,1810	COX-2	1630,1635	prostaglandin	COX-2	CHEBI:26333	5743	Chemical	Gene	levels|compound|START_ENTITY contribute|nmod|levels suggesting|ccomp|contribute induced|xcomp|suggesting induced|nsubjpass|transcription transcription|compound|END_ENTITY	Finally , COX-2 transcription is also induced at febrile temperatures in endothelial cells , suggesting that HSF1-dependent COX-2 expression could contribute to increasing blood prostaglandin levels during fever .
20188355	0	prostaglandin	75,88	Cyclooxygenase-2	0,16	prostaglandin	Cyclooxygenase-2	CHEBI:26333	5743	Chemical	Gene	synthesis|compound|START_ENTITY induction|nmod|synthesis evidence|nmod|induction END_ENTITY|dep|evidence	Cyclooxygenase-2 in testes of infertile men : evidence for the induction of prostaglandin synthesis by interleukin-1b .
22230338	0	prostaglandin	46,59	DDT	14,17	prostaglandin	DDT	CHEBI:26333	615999(Tax:9913)	Chemical	Gene	secretion|compound|START_ENTITY effect|nmod|secretion effect|nmod|END_ENTITY	The effect of DDT and its metabolite -LRB- DDE -RRB- on prostaglandin secretion from epithelial cells and on contractions of the smooth muscle of the bovine oviduct in vitro .
12411813	0	prostaglandin	8,21	EP1	31,34	prostaglandin	EP1	CHEBI:26333	25637(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY Role|nmod|receptor END_ENTITY|nsubj|Role	Role of prostaglandin receptor EP1 in the spinal dorsal horn in carrageenan-induced inflammatory_pain .
15126118	0	prostaglandin	8,21	EP1	39,42	prostaglandin	EP1	CHEBI:26333	25637(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY Role|nmod|receptor subtype|nsubj|Role subtype|dobj|END_ENTITY	Role of prostaglandin receptor subtype EP1 in prostaglandin_E2-induced nociceptive transmission in the rat spinal dorsal horn .
16877408	0	prostaglandin	15,28	EP1	53,56	prostaglandin	EP1	CHEBI:26333	19216(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY analogues|nsubj|effects analogues|nmod|END_ENTITY	The effects of prostaglandin analogues on prostanoid EP1 , EP2 , and EP3 receptor-deficient mice .
24614038	0	prostaglandin	16,29	EP1	39,42	prostaglandin	EP1	CHEBI:26333	5731	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Upregulation of prostaglandin receptor EP1 expression involves its association with cyclooxygenase-2 .
17531488	0	prostaglandin	19,32	EP2	73,76	prostaglandin	EP2	CHEBI:26333	5732	Chemical	Gene	analogs|compound|START_ENTITY analogs|nmod|PGE2 PGE2|nmod|END_ENTITY	Discovery of novel prostaglandin analogs of PGE2 as potent and selective EP2 and EP4 receptor agonists .
20399827	0	prostaglandin	103,116	EP2	117,120	prostaglandin	EP2	CHEBI:26333	5732	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Expression profiling of cumulus cells reveals functional changes during ovulation and central roles of prostaglandin EP2 receptor in cAMP signaling .
23192657	0	prostaglandin	8,21	EP2	31,34	prostaglandin	EP2	CHEBI:26333	5732	Chemical	Gene	receptor|compound|START_ENTITY Role|nmod|receptor END_ENTITY|nsubj|Role	Role of prostaglandin receptor EP2 in the regulations of cancer cell proliferation , invasion , and inflammation .
9730918	0	prostaglandin	44,57	EP2	40,43	prostaglandin	EP2	CHEBI:26333	5732	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	A single amino-acid substitution in the EP2 prostaglandin receptor confers responsiveness to prostacyclin analogs .
9785384	0	prostaglandin	72,85	EP2	86,89	prostaglandin	EP2	CHEBI:26333	5732	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Potentiation of retinoic_acid-induced differentiation of HL-60 cells by prostaglandin EP2 receptor .
10082673	0	prostaglandin	30,43	EP3	44,47	prostaglandin	EP3	CHEBI:26333	19218(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	The key amino_acid residue of prostaglandin EP3 receptor for governing G protein association and activation steps .
10802063	0	prostaglandin	32,45	EP3	46,49	prostaglandin	EP3	CHEBI:26333	19218(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Different membrane targeting of prostaglandin EP3 receptor isoforms dependent on their carboxy-terminal tail structures .
11779148	0	prostaglandin	74,87	EP3	105,108	prostaglandin	EP3	CHEBI:26333	24929(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY activity|nmod|receptor Augmentation|nmod|activity subtype|nsubj|Augmentation subtype|dobj|END_ENTITY	Augmentation of receptor-mediated adenylyl cyclase activity by Gi-coupled prostaglandin receptor subtype EP3 in a Gbetagamma subunit-independent manner .
9681455	0	prostaglandin	34,47	EP3	48,51	prostaglandin	EP3	CHEBI:26333	24929(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Inhibition of dopamine release by prostaglandin EP3 receptor via pertussis toxin-sensitive and - insensitive pathways in PC12 cells .
10882227	0	prostaglandin	24,37	EP4	38,41	prostaglandin	EP4	CHEBI:26333	84023(Tax:10116)	Chemical	Gene	expression|compound|START_ENTITY expression|nummod|END_ENTITY	Effect of rebamipide on prostaglandin EP4 receptor gene expression in rat gastric_mucosa .
12131119	0	prostaglandin	41,54	EP4	72,75	prostaglandin	EP4	CHEBI:26333	5734	Chemical	Gene	receptor|compound|START_ENTITY agonist|nmod|receptor Effects|nmod|agonist subtype|nsubj|Effects subtype|dobj|END_ENTITY	Effects of a novel selective agonist for prostaglandin receptor subtype EP4 on hyperalgesia and inflammation in monoarthritic model .
19322876	0	prostaglandin	12,25	EP4	26,29	prostaglandin	EP4	CHEBI:26333	5734	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Effect of a prostaglandin EP4 receptor agonist on early fixation of hydroxyapatite/titanium composite - and titanium-coated rough-surfaced implants in ovariectomized rats .
19344793	0	prostaglandin	93,106	EP4	46,49	prostaglandin	EP4	CHEBI:26333	19219(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|receptor receptor|compound|END_ENTITY	Effects of global or targeted deletion of the EP4 receptor on the response of osteoblasts to prostaglandin in vitro and on bone histomorphometry in aged mice .
9846175	0	prostaglandin	36,49	EP4	18,21	prostaglandin	EP4	CHEBI:26333	19219(Tax:10090)	Chemical	Gene	subtype|nmod|START_ENTITY receptor|amod|subtype END_ENTITY|appos|receptor	Important role of EP4 , a subtype of prostaglandin -LRB- PG -RRB- E receptor , in osteoclast-like_cell formation from mouse bone marrow cells induced by PGE2 .
10563545	0	prostaglandin	79,92	Epidermal_growth_factor	0,23	prostaglandin	Epidermal growth factor	CHEBI:26333	25313(Tax:10116)	Chemical	Gene	dependent|advmod|START_ENTITY effect|amod|dependent colon|appos|effect flow|nmod|colon increases|dobj|flow increases|nsubj|END_ENTITY	Epidermal_growth_factor increases basal mucosal blood flow in the rat colon , a prostaglandin dependent effect .
23051736	0	prostaglandin	50,63	Fascin	11,17	prostaglandin	Fascin	CHEBI:26333	31717(Tax:7227)	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Drosophila Fascin is a novel downstream target of prostaglandin signaling during actin remodeling .
6212125	0	prostaglandin	18,31	Fc_gamma_receptor	40,57	prostaglandin	Fc gamma receptor	CHEBI:26333	2209	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Monocyte-produced prostaglandin induces Fc_gamma_receptor expression on human T cells .
10189071	0	prostaglandin	23,36	IL-1alpha	10,19	prostaglandin	IL-1alpha	CHEBI:26333	24493(Tax:10116)	Chemical	Gene	synthesis|compound|START_ENTITY END_ENTITY|nmod|synthesis	Effect of IL-1alpha on prostaglandin synthesis of oestrogenized rat uterus is mediated by nitric_oxide .
10882189	0	prostaglandin	18,31	IL1alpha	0,8	prostaglandin	IL1alpha	CHEBI:26333	24493(Tax:10116)	Chemical	Gene	synthesis|compound|START_ENTITY augments|dobj|synthesis augments|nsubj|END_ENTITY	IL1alpha augments prostaglandin synthesis in pregnant rat uteri by a nitric_oxide mediated mechanism .
10735591	0	prostaglandin	39,52	Interleukin-1	0,13	prostaglandin	Interleukin-1	CHEBI:26333	3552	Chemical	Gene	production|compound|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Interleukin-1 stimulates human uterine prostaglandin production through induction of cyclooxygenase-2 expression .
7669843	0	prostaglandin	30,43	Interleukin-1_alpha	0,19	prostaglandin	Interleukin-1 alpha	CHEBI:26333	24493(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	Interleukin-1_alpha regulates prostaglandin production and cyclooxygenase activity in sensitized rat endometrial stromal cells in vitro .
10397407	0	prostaglandin	39,52	Interleukin-4	0,13	prostaglandin	Interleukin-4	CHEBI:26333	3565	Chemical	Gene	production|compound|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	Interleukin-4 differentially regulates prostaglandin production in amnion-derived WISH cells stimulated with pro-inflammatory cytokines and epidermal_growth_factor .
2040361	0	prostaglandin	25,38	Interleukin-6	0,13	prostaglandin	Interleukin-6	CHEBI:26333	3569	Chemical	Gene	production|compound|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Interleukin-6 stimulates prostaglandin production by human amnion and decidual cells .
6769661	0	prostaglandin	15,28	LHRH	84,88	prostaglandin	LHRH	CHEBI:26333	25194(Tax:10116)	Chemical	Gene	accumulation|compound|START_ENTITY accumulation|nmod|END_ENTITY	Stimulation of prostaglandin accumulation by luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- and LHRH analogs in rat granulosa cells in vitro .
22031854	0	prostaglandin	79,92	OAT-PG	106,112	prostaglandin	OAT-PG	CHEBI:26333	299944(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY expression|nmod|transporter difference|nmod|expression induce|dobj|difference induce|advmod|END_ENTITY	Sex hormones induce a gender-related difference in renal expression of a novel prostaglandin transporter , OAT-PG , influencing basal PGE2 concentration .
24008262	0	prostaglandin	32,45	OAT-PG	59,65	prostaglandin	OAT-PG	CHEBI:26333	299944(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY expression|nmod|transporter facilitates|nsubj|expression facilitates|advmod|END_ENTITY	Decreased expression of a novel prostaglandin transporter , OAT-PG , facilitates renocortical PGE2 accumulation during rat pregnancy .
24057348	0	prostaglandin	71,84	OAT-PG	45,51	prostaglandin	OAT-PG	CHEBI:26333	299944(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|appos|transporter	Glucocorticoid mediates the transcription of OAT-PG , a kidney-specific prostaglandin transporter .
10480490	0	prostaglandin	32,45	PLA2	24,28	prostaglandin	PLA2	CHEBI:26333	151056	Chemical	Gene	formation|compound|START_ENTITY END_ENTITY|nmod|formation	Contribution of type II PLA2 to prostaglandin formation : a study using a type II PLA2 specific inhibitor SB_203347 .
10480490	0	prostaglandin	32,45	PLA2	81,85	prostaglandin	PLA2	CHEBI:26333	151056	Chemical	Gene	formation|compound|START_ENTITY PLA2|nmod|formation Contribution|nmod|PLA2 Contribution|dep|study study|acl|using using|dobj|type type|dep|SB_203347 SB_203347|compound|END_ENTITY	Contribution of type II PLA2 to prostaglandin formation : a study using a type II PLA2 specific inhibitor SB_203347 .
8829212	0	prostaglandin	26,39	Renin	0,5	prostaglandin	Renin	CHEBI:26333	5972	Chemical	Gene	production|compound|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Renin stimulates decidual prostaglandin production via a novel mechanism that is independent of angiotensin_II formation .
19807916	0	prostaglandin	54,67	SLCO2A1	81,88	prostaglandin	SLCO2A1	CHEBI:26333	100144510(Tax:9823)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Molecular cloning and characterization of the porcine prostaglandin transporter -LRB- SLCO2A1 -RRB- : evaluation of its role in F4 mediated neonatal_diarrhoea .
2903014	0	prostaglandin	24,37	Somatostatin	0,12	prostaglandin	Somatostatin	CHEBI:26333	24797(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Somatostatin stimulates prostaglandin production by rat gastric epithelial cells in vitro , but is not cytoprotective .
1569057	0	prostaglandin	54,67	TIS10	48,53	prostaglandin	TIS10	CHEBI:26333	19225(Tax:10090)	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Dexamethasone inhibits mitogen induction of the TIS10 prostaglandin synthase/cyclooxygenase gene .
1712772	0	prostaglandin	91,104	TIS10	0,5	prostaglandin	TIS10	CHEBI:26333	19225(Tax:10090)	Chemical	Gene	synthase/cyclooxygenase|compound|START_ENTITY encodes|dobj|synthase/cyclooxygenase encodes|nsubj|END_ENTITY	TIS10 , a phorbol_ester_tumor promoter-inducible mRNA from Swiss_3T3 cells , encodes a novel prostaglandin synthase/cyclooxygenase homologue .
20035107	0	prostaglandin	112,125	VEGF	104,108	prostaglandin	VEGF	CHEBI:26333	281572(Tax:9913)	Chemical	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	Expression of VEGF and its receptors in the bovine endometrium throughout the estrous cycle : effects of VEGF on prostaglandin production in endometrial cells .
20035107	0	prostaglandin	112,125	VEGF	14,18	prostaglandin	VEGF	CHEBI:26333	281572(Tax:9913)	Chemical	Gene	production|compound|START_ENTITY VEGF|nmod|production effects|nmod|VEGF Expression|dep|effects Expression|nmod|END_ENTITY	Expression of VEGF and its receptors in the bovine endometrium throughout the estrous cycle : effects of VEGF on prostaglandin production in endometrial cells .
27091669	0	prostaglandin	10,23	VEGF	30,34	prostaglandin	VEGF	CHEBI:26333	7422	Chemical	Gene	D2|compound|START_ENTITY D2|nmod|END_ENTITY	Effect of prostaglandin D2 on VEGF release by nasal polyp fibroblasts .
10855742	0	prostaglandin	62,75	angiotensin_II	32,46	prostaglandin	angiotensin II	CHEBI:26333	24179(Tax:10116)	Chemical	Gene	infusion|nmod|START_ENTITY infusion|amod|END_ENTITY	Regional renal haemodynamics of angiotensin_II infusion under prostaglandin , kinin or converting enzyme inhibition in the Wistar rat .
1550682	0	prostaglandin	28,41	bradykinin	62,72	prostaglandin	bradykinin	CHEBI:26333	478666(Tax:9615)	Chemical	Gene	secretion|compound|START_ENTITY distribution|nmod|secretion caused|nsubj|distribution caused|nmod|END_ENTITY	Topographic distribution of prostaglandin secretion caused by bradykinin in canine tracheal epithelial cells .
18475453	0	prostaglandin	74,87	bradykinin	14,24	prostaglandin	bradykinin	CHEBI:26333	280833(Tax:9913)	Chemical	Gene	factor|compound|START_ENTITY release|nmod|factor stimulated|dobj|release stimulated|nsubj|Mechanisms Mechanisms|nmod|END_ENTITY	Mechanisms in bradykinin stimulated arachidonate release and synthesis of prostaglandin and platelet activating factor .
2555202	0	prostaglandin	72,85	bradykinin	33,43	prostaglandin	bradykinin	CHEBI:26333	3827	Chemical	Gene	synthesis|compound|START_ENTITY stimulation|nmod|synthesis stimulation|compound|END_ENTITY	Diacylglycerol in the synergy of bradykinin and thrombin stimulation of prostaglandin synthesis .
26235941	0	prostaglandin	44,57	bradykinin	73,83	prostaglandin	bradykinin	CHEBI:26333	3827	Chemical	Gene	release|compound|START_ENTITY Enhanced|nmod|release Enhanced|nmod|B2_receptor B2_receptor|compound|END_ENTITY	Enhanced Ca -LRB- 2 + -RRB- response and stimulation of prostaglandin release by the bradykinin B2_receptor in human retinal pigment epithelial cells primed with proinflammatory cytokines .
2894457	0	prostaglandin	53,66	bradykinin	9,19	prostaglandin	bradykinin	CHEBI:26333	280833(Tax:9913)	Chemical	Gene	synthesis|compound|START_ENTITY stimulation|nmod|synthesis mediate|dobj|stimulation mediate|nsubj|receptors receptors|compound|END_ENTITY	Distinct bradykinin receptors mediate stimulation of prostaglandin synthesis by endothelial cells and fibroblasts .
679427	0	prostaglandin	14,27	bradykinin	97,107	prostaglandin	bradykinin	CHEBI:26333	478666(Tax:9615)	Chemical	Gene	synthesis|compound|START_ENTITY Inhibition|nmod|synthesis augments|nsubj|Inhibition augments|advcl|END_ENTITY	Inhibition of prostaglandin synthesis by indomethacin augments the renal vasodilator response to bradykinin in the anesthetized dog .
6806549	0	prostaglandin	14,27	bradykinin	89,99	prostaglandin	bradykinin	CHEBI:26333	3827	Chemical	Gene	modulation|compound|START_ENTITY Difference|nmod|modulation Difference|nmod|END_ENTITY	Difference in prostaglandin modulation of arterial and venous smooth muscle responses to bradykinin and norepinephrine .
887800	0	prostaglandin	30,43	bradykinin	16,26	prostaglandin	bradykinin	CHEBI:26333	280833(Tax:9913)	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	Dual effects of bradykinin on prostaglandin metabolism : relationship to the dissimilar vascular actions of kinins .
10027864	0	prostaglandin	14,27	cyclooxygenase-2	51,67	prostaglandin	cyclooxygenase-2	CHEBI:26333	5743	Chemical	Gene	synthesis|compound|START_ENTITY Inhibition|nmod|synthesis up-regulates|nsubj|Inhibition up-regulates|dobj|induced induced|amod|END_ENTITY	Inhibition of prostaglandin synthesis up-regulates cyclooxygenase-2 induced by lipopolysaccharide and peroxisomal proliferators .
10735591	0	prostaglandin	39,52	cyclooxygenase-2	85,101	prostaglandin	cyclooxygenase-2	CHEBI:26333	5743	Chemical	Gene	production|compound|START_ENTITY stimulates|dobj|production stimulates|nmod|induction induction|nmod|expression expression|amod|END_ENTITY	Interleukin-1 stimulates human uterine prostaglandin production through induction of cyclooxygenase-2 expression .
10874015	0	prostaglandin	31,44	cyclooxygenase-2	57,73	prostaglandin	cyclooxygenase-2	CHEBI:26333	5743	Chemical	Gene	production|compound|START_ENTITY production|appos|mRNA mRNA|amod|END_ENTITY	Areca nut extract up-regulates prostaglandin production , cyclooxygenase-2 mRNA and protein expression of human oral keratinocytes .
12414896	0	prostaglandin	119,132	cyclooxygenase-2	86,102	prostaglandin	cyclooxygenase-2	CHEBI:26333	5743	Chemical	Gene	dehydrogenase|compound|START_ENTITY immunostaining|nmod|dehydrogenase immunostaining|nmod|END_ENTITY	Mifepristone-induced vaginal_bleeding is associated with increased immunostaining for cyclooxygenase-2 and decrease in prostaglandin dehydrogenase in luteal phase endometrium .
14623055	0	prostaglandin	44,57	cyclooxygenase-2	26,42	prostaglandin	cyclooxygenase-2	CHEBI:26333	19225(Tax:10090)	Chemical	Gene	EP2|dep|START_ENTITY EP2|amod|END_ENTITY	The effect of deletion of cyclooxygenase-2 , prostaglandin receptor EP2 , or EP4 in bone marrow cells on osteoclasts induced by mouse mammary cancer cell lines .
15121014	0	prostaglandin	88,101	cyclooxygenase-2	35,51	prostaglandin	cyclooxygenase-2	CHEBI:26333	19225(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Stimulation of cAMP production and cyclooxygenase-2 by prostaglandin_E -LRB- 2 -RRB- and selective prostaglandin receptor agonists in murine osteoblastic cells .
15517155	0	prostaglandin	77,90	cyclooxygenase-2	46,62	prostaglandin	cyclooxygenase-2	CHEBI:26333	5743	Chemical	Gene	release|compound|START_ENTITY inhibitors|nmod|release inhibitors|amod|END_ENTITY	-LSB- In vitro effects of diclofenac and selective cyclooxygenase-2 inhibitors on prostaglandin release from inflamed bursa subacromialis tissue in patients with subacromial_syndrome -RSB- .
24603686	0	prostaglandin	26,39	cyclooxygenase-2	113,129	prostaglandin	cyclooxygenase-2	CHEBI:26333	19225(Tax:10090)	Chemical	Gene	barricading|nmod|START_ENTITY biosynthesis|nsubj|barricading biosynthesis|parataxis|understanding understanding|dobj|mechanism mechanism|nmod|inhibition inhibition|amod|END_ENTITY	The bitter barricading of prostaglandin biosynthesis pathway : understanding the molecular mechanism of selective cyclooxygenase-2 inhibition by amarogentin , a secoiridoid_glycoside from Swertia chirayita .
24614038	0	prostaglandin	16,29	cyclooxygenase-2	84,100	prostaglandin	cyclooxygenase-2	CHEBI:26333	5743	Chemical	Gene	expression|compound|START_ENTITY Upregulation|nmod|expression involves|nsubj|Upregulation involves|advcl|END_ENTITY	Upregulation of prostaglandin receptor EP1 expression involves its association with cyclooxygenase-2 .
7636805	0	prostaglandin	41,54	epidermal_growth_factor	14,37	prostaglandin	epidermal growth factor	CHEBI:26333	25313(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	Regulation by epidermal_growth_factor of prostaglandin production and cyclooxygenase activity in sensitized rat endometrial stromal cells in vitro .
8311923	0	prostaglandin	125,138	epidermal_growth_factor	98,121	prostaglandin	epidermal growth factor	CHEBI:26333	1950	Chemical	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	Evidence for a common mechanism of action of interleukin-1_beta , tumor necrosis factor-alpha , and epidermal_growth_factor on prostaglandin production in human chorion cells .
7243104	0	prostaglandin	18,31	hCG	11,14	prostaglandin	hCG	CHEBI:26333	3342	Chemical	Gene	synthesis|compound|START_ENTITY Effects|nmod|synthesis Effects|nmod|END_ENTITY	Effects of hCG on prostaglandin synthesis and function of corpus luteum .
9832484	0	prostaglandin	6,19	hPGT	38,42	prostaglandin	hPGT	CHEBI:26333	6578	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Human prostaglandin transporter gene -LRB- hPGT -RRB- is regulated by fluid mechanical stimuli in cultured endothelial cells and expressed in vascular endothelium in vivo .
15451438	0	prostaglandin	35,48	heme_oxygenase-1	10,26	prostaglandin	heme oxygenase-1	CHEBI:26333	3162	Chemical	Gene	uptake|compound|START_ENTITY induces|dobj|uptake induces|nsubj|END_ENTITY	Augmented heme_oxygenase-1 induces prostaglandin uptake via the prostaglandin_transporter in micro-vascular endothelial cells .
15328215	0	prostaglandin	46,59	interferon-tau	24,38	prostaglandin	interferon-tau	CHEBI:26333	317698(Tax:9913)	Chemical	Gene	pathway|compound|START_ENTITY END_ENTITY|nmod|pathway	Differential effects of interferon-tau on the prostaglandin synthetic pathway in bovine endometrial cells treated with phorbol_ester .
11774411	0	prostaglandin	49,62	interleukin-1_and_dexamethasone	14,45	prostaglandin	interleukin-1 and dexamethasone	CHEBI:26333	3552	Chemical	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	-LSB- Influence of interleukin-1_and_dexamethasone on prostaglandin production of condylar chondrocytes -RSB- .
20188355	0	prostaglandin	75,88	interleukin-1b	102,116	prostaglandin	interleukin-1b	CHEBI:26333	3553	Chemical	Gene	synthesis|compound|START_ENTITY synthesis|nmod|END_ENTITY	Cyclooxygenase-2 in testes of infertile men : evidence for the induction of prostaglandin synthesis by interleukin-1b .
2383610	0	prostaglandin	44,57	oxytocin	10,18	prostaglandin	oxytocin	CHEBI:26333	5020	Chemical	Gene	release|compound|START_ENTITY Effect|nmod|release Effect|nmod|END_ENTITY	Effect of oxytocin and estradiol on uterine prostaglandin release in nonpregnant and early-pregnant ewes .
3862579	0	prostaglandin	47,60	parathyroid_hormone	11,30	prostaglandin	parathyroid hormone	CHEBI:26333	24694(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY Effects|nmod|production Effects|nmod|END_ENTITY	Effects of parathyroid_hormone and cortisol on prostaglandin production by neonatal rat calvaria in vitro .
17526477	0	prostaglandin	14,27	part_1	38,44	prostaglandin	part 1	CHEBI:26333	25859	Chemical	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Modulation of prostaglandin activity , part_1 : prostaglandin inhibition in the management of nonrheumatologic_diseases : immunologic and hematologic aspects .
2293202	0	prostaglandin	64,77	phospholipase_C	92,107	prostaglandin	phospholipase C	CHEBI:26333	100009319(Tax:9986)	Chemical	Gene	synthesis|compound|START_ENTITY synthesis|nmod|END_ENTITY	Adenosine-5 ' - triphosphate-induced sinus_tachycardia mediated by prostaglandin synthesis via phospholipase_C in the rabbit heart .
8582856	0	prostaglandin	68,81	pregnancy-specific_protein_B	10,38	prostaglandin	pregnancy-specific protein B	CHEBI:26333	281964(Tax:9913)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of pregnancy-specific_protein_B on luteal cell progesterone , prostaglandin , and oxytocin production during two stages of the bovine estrous cycle .
3927900	0	prostaglandin	19,32	transforming_growth_factor-alpha	47,79	prostaglandin	transforming growth factor-alpha	CHEBI:26333	24827(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	The stimulation of prostaglandin production by transforming_growth_factor-alpha and 12-O-tetradecanoyl-phorbol-13-acetate or 1-oleoyl-2-acetyl-glycerol is synergistic .
18339853	0	prostaglandin-E2	61,77	cyclooxygenase-2	31,47	prostaglandin-E2	cyclooxygenase-2	MESH:D015232	5743	Chemical	Gene	synthesis|amod|START_ENTITY END_ENTITY|nmod|synthesis	Lipid bodies are reservoirs of cyclooxygenase-2 and sites of prostaglandin-E2 synthesis in colon_cancer cells .
14715242	0	prostaglandin-J2	20,36	HIF-1	78,83	prostaglandin-J2	HIF-1	MESH:C037112	3091	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|role role|nmod|END_ENTITY	Opposite effects of prostaglandin-J2 on VEGF in normoxia and hypoxia : role of HIF-1 .
8181472	0	prostaglandin-endoperoxide	52,78	PTGS2	36,41	prostaglandin-endoperoxide	PTGS2	null	5743	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of the human gene -LRB- PTGS2 -RRB- encoding prostaglandin-endoperoxide synthase 2 .
744259	0	prostaglandin_A	10,25	renin	29,34	prostaglandin A	renin	null	403838(Tax:9615)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of prostaglandin_A on renin secretion in the dog .
15889622	0	prostaglandin_A2	13,29	Bax	56,59	prostaglandin A2	Bax	MESH:C100008	581	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|levels levels|amod|END_ENTITY	Influence of prostaglandin_A2 and 2-methoxyestradiol on Bax and Bcl-2 expression levels in cervical_carcinoma cells .
9824682	0	prostaglandin_A2	109,125	c-Myc	12,17	prostaglandin A2	c-Myc	MESH:C100008	4609	Chemical	Gene	Delta12-prostaglandin_J2|amod|START_ENTITY induced|nmod|Delta12-prostaglandin_J2 induced|nsubj|role role|nmod|cells cells|amod|END_ENTITY	The role of c-Myc and heat_shock_protein_70 in human hepatocarcinoma Hep3B cells during apoptosis induced by prostaglandin_A2 / Delta12-prostaglandin_J2 .
3162825	0	prostaglandin_A2	22,38	c-myc	42,47	prostaglandin A2	c-myc	MESH:C100008	4609	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Inhibitory effects of prostaglandin_A2 on c-myc expression and cell cycle progression in human leukemia cell line HL-60 .
21887724	0	prostaglandin_D	14,29	H-Pgds	40,46	prostaglandin D	H-Pgds	null	54486(Tax:10090)	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	Hematopoietic prostaglandin_D synthase -LRB- H-Pgds -RRB- is expressed in the early embryonic gonad and participates to the initial nuclear translocation of the SOX9 protein .
21821144	0	prostaglandin_D	14,29	HPGDS	40,45	prostaglandin D	HPGDS	null	27306	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	Hematopoietic prostaglandin_D synthase -LRB- HPGDS -RRB- : a high stability , Val187Ile isoenzyme common among African Americans and its relationship to risk for colorectal_cancer .
17200838	0	prostaglandin_D	68,83	MK-0524	14,21	prostaglandin D	MK-0524	null	1476625(Tax:190192)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of MK-0524 , a prostaglandin_D -LRB- 2 -RRB- receptor antagonist , on prostaglandin_D -LRB- 2 -RRB- - induced nasal airway obstruction in healthy volunteers .
15047795	0	prostaglandin_D2	75,91	BICP0	23,28	prostaglandin D2	BICP0	MESH:D015230	1487364(Tax:10320)	Chemical	Gene	blocked|nmod|START_ENTITY blocked|nsubjpass|END_ENTITY	Transactivator protein BICP0 of bovine_herpesvirus_1 _ -LRB- BHV-1 -RRB- is blocked by prostaglandin_D2 -LRB- PGD2 -RRB- , which points to a mechanism for PGD2-mediated inhibition of BHV-1 replication .
24523542	0	prostaglandin_D2	24,40	CRTH2	8,13	prostaglandin D2	CRTH2	MESH:D015230	14764(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY END_ENTITY|appos|receptor	Central CRTH2 , a second prostaglandin_D2 receptor , mediates emotional impairment in the lipopolysaccharide and tumor-induced sickness_behavior model .
17910949	0	prostaglandin_D2	51,67	CRTh2	42,47	prostaglandin D2	CRTh2	MESH:D015230	11251	Chemical	Gene	receptor|amod|START_ENTITY END_ENTITY|appos|receptor	Characterization of the promoter of human CRTh2 , a prostaglandin_D2 receptor .
11804951	0	prostaglandin_D2	63,79	Cyclooxygenase-2	0,16	prostaglandin D2	Cyclooxygenase-2	MESH:D015230	29527(Tax:10116)	Chemical	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Cyclooxygenase-2 regulates apoptosis in rat epididymis through prostaglandin_D2 .
25964109	0	prostaglandin_D2	23,39	L-PGDS	50,56	prostaglandin D2	L-PGDS	MESH:D015230	19215(Tax:10090)	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	Role of Lipocalin-type prostaglandin_D2 synthase -LRB- L-PGDS -RRB- and its metabolite , prostaglandin_D2 , in preterm_birth .
25964109	0	prostaglandin_D2	78,94	L-PGDS	50,56	prostaglandin D2	L-PGDS	MESH:D015230	19215(Tax:10090)	Chemical	Gene	Role|amod|START_ENTITY Role|nmod|synthase synthase|appos|END_ENTITY	Role of Lipocalin-type prostaglandin_D2 synthase -LRB- L-PGDS -RRB- and its metabolite , prostaglandin_D2 , in preterm_birth .
24101662	0	prostaglandin_D2	11,27	Nrf2	116,120	prostaglandin D2	Nrf2	MESH:D015230	18024(Tax:10090)	Chemical	Gene	protect|nsubj|START_ENTITY protect|nmod|END_ENTITY	Endogenous prostaglandin_D2 and its metabolites protect the heart against ischemia-reperfusion injury by activating Nrf2 .
25968070	0	prostaglandin_D2	77,93	Nrf2	23,27	prostaglandin D2	Nrf2	MESH:D015230	4780	Chemical	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Close teamwork between Nrf2 and peroxiredoxins_1_and_6 for the regulation of prostaglandin_D2 and E2 production in macrophages in acute inflammation .
9388257	0	prostaglandin_D2	48,64	Tumor_necrosis_factor-alpha	0,27	prostaglandin D2	Tumor necrosis factor-alpha	MESH:D015230	21926(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha inversely regulates prostaglandin_D2 and prostaglandin_E2 production in murine macrophages .
6598030	0	prostaglandin_D2	29,45	growth_hormone	49,63	prostaglandin D2	growth hormone	MESH:D015230	81668(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	Direct suppressive effect of prostaglandin_D2 on growth_hormone secretion from rat anterior pituitary .
11755918	0	prostaglandin_D2	44,60	interleukin-8	16,29	prostaglandin D2	interleukin-8	MESH:D015230	3576	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Upregulation of interleukin-8 expression by prostaglandin_D2 metabolite 15-deoxy-delta12 , _ 14_prostaglandin_J2 -LRB- 15d-PGJ2 -RRB- in human THP-1 macrophages .
23791868	0	prostaglandin_E	39,54	15-hydroxyprostaglandin_dehydrogenase	84,121	prostaglandin E	15-hydroxyprostaglandin dehydrogenase	null	3248	Chemical	Gene	Control|nmod|START_ENTITY Control|nmod|END_ENTITY	Control of the intracellular levels of prostaglandin_E through inhibition of the 15-hydroxyprostaglandin_dehydrogenase for wound healing .
23623753	0	prostaglandin_E	57,72	5-lipoxygenase	27,41	prostaglandin E	5-lipoxygenase	null	240	Chemical	Gene	START_ENTITY|nsubj|inhibition inhibition|nmod|END_ENTITY	Potent inhibition of human 5-lipoxygenase and microsomal prostaglandin_E synthase-1 by the anti-carcinogenic and anti-inflammatory agent embelin .
2952748	0	prostaglandin_E	52,67	C3b	11,14	prostaglandin E	C3b	null	718	Chemical	Gene	release|nmod|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Cell-bound C3b stimulates human monocyte release of prostaglandin_E and thromboxane_B2 .
7690750	0	prostaglandin_E	58,73	EP1	43,46	prostaglandin E	EP1	null	19216(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY subtype|nmod|receptor subtype|compound|END_ENTITY	Cloning and expression of cDNA for a mouse EP1 subtype of prostaglandin_E receptor .
12940822	0	prostaglandin_E	98,113	EP2	131,134	prostaglandin E	EP2	null	19217(Tax:10090)	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Identification and characterization of a novel progesterone receptor-binding element in the mouse prostaglandin_E receptor subtype EP2 gene .
15481309	0	prostaglandin_E	97,112	EP2	122,125	prostaglandin E	EP2	null	81752(Tax:10116)	Chemical	Gene	subtype|amod|START_ENTITY subtype|compound|END_ENTITY	Prostaglandin_E2 inhibits platelet-derived growth factor-stimulated cell proliferation through a prostaglandin_E receptor EP2 subtype in rat hepatic stellate cells .
21261791	0	prostaglandin_E	86,101	EP2	112,115	prostaglandin E	EP2	null	5732	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	4 - -LRB- Methylnitrosamino -RRB- -1 - -LRB- 3-pyridyl -RRB- -1 - butanone promoted gastric_cancer growth through prostaglandin_E receptor -LRB- EP2 and EP4 -RRB- in vivo and in vitro .
11095474	0	prostaglandin_E	50,65	EP3	75,78	prostaglandin E	EP3	null	5733	Chemical	Gene	isoforms|amod|START_ENTITY isoforms|compound|END_ENTITY	Multiple signal transduction pathways through two prostaglandin_E receptor EP3 subtype isoforms expressed in human uterus .
20015609	0	prostaglandin_E	47,62	EP3	43,46	prostaglandin E	EP3	null	19218(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Recruited bone marrow cells expressing the EP3 prostaglandin_E receptor subtype enhance angiogenesis during chronic_inflammation .
7945376	0	prostaglandin_E	6,21	EP3	31,34	prostaglandin E	EP3	null	19218(Tax:10090)	Chemical	Gene	subtype|compound|START_ENTITY subtype|compound|END_ENTITY	Mouse prostaglandin_E receptor EP3 subtype mediates calcium signals via Gi in cDNA-transfected Chinese_hamster ovary cells .
8198593	0	prostaglandin_E	48,63	EP3	73,76	prostaglandin E	EP3	null	19218(Tax:10090)	Chemical	Gene	isoforms|amod|START_ENTITY isoforms|compound|END_ENTITY	Enhancement of adenylate cyclase stimulation by prostaglandin_E receptor EP3 subtype isoforms with different efficiencies .
8935703	0	prostaglandin_E	41,56	EP3	66,69	prostaglandin E	EP3	null	24929(Tax:10116)	Chemical	Gene	subtype|amod|START_ENTITY subtype|compound|END_ENTITY	Membrane depolarization by activation of prostaglandin_E receptor EP3 subtype of putative serotonergic neurons in the dorsal raphe nucleus of the rat .
11083800	0	prostaglandin_E	80,95	EP4	105,108	prostaglandin E	EP4	null	19219(Tax:10090)	Chemical	Gene	subtype|amod|START_ENTITY subtype|compound|END_ENTITY	Impaired bone resorption by lipopolysaccharide in vivo in mice deficient in the prostaglandin_E receptor EP4 subtype .
16997129	0	prostaglandin_E	14,29	EP4	39,42	prostaglandin E	EP4	null	19219(Tax:10090)	Chemical	Gene	subtype|amod|START_ENTITY subtype|compound|END_ENTITY	Activation of prostaglandin_E receptor EP4 subtype suppresses food intake in mice .
2104754	0	prostaglandin_E	44,59	Fatty_acid_binding_protein	0,26	prostaglandin E	Fatty acid binding protein	null	25721(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|modulates modulates|amod|END_ENTITY	Fatty_acid_binding_protein -LRB- FABP -RRB- modulates prostaglandin_E binding to rat epididymal adipocyte membrane similarly to albumin .
14602805	0	prostaglandin_E	105,120	PGES	131,135	prostaglandin E	PGES	null	9536	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Glucocorticoids induce cytosolic phospholipase A2 and prostaglandin_H_synthase_type_2 but not microsomal prostaglandin_E synthase -LRB- PGES -RRB- and cytosolic PGES expression in cultured primary human amnion cells .
18666211	0	prostaglandin_E	49,64	PTGER2	77,83	prostaglandin E	PTGER2	null	5732	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Clinical significance of aberrant methylation of prostaglandin_E receptor 2 -LRB- PTGER2 -RRB- in nonsmall_cell_lung_cancer : association with prognosis , PTGER2 expression , and epidermal_growth_factor_receptor mutation .
17022010	0	prostaglandin_E	39,54	cyclo-oxygenase_1_and_2	14,37	prostaglandin E	cyclo-oxygenase 1 and 2	null	5742;5743	Chemical	Gene	synthase|amod|START_ENTITY synthase|amod|END_ENTITY	Expression of cyclo-oxygenase_1_and_2 , prostaglandin_E synthase and transforming_growth_factor_beta1 , and their relationship with vascular_endothelial_growth_factors A and C , in primary adenocarcinoma_of_the_small_intestine .
12860389	0	prostaglandin_E	119,134	cyclooxygenase-2	87,103	prostaglandin E	cyclooxygenase-2	null	5743	Chemical	Gene	synthase|compound|START_ENTITY synthase|amod|END_ENTITY	IL-1beta-dependent activation of NF-kappaB mediates PGE2 release via the expression of cyclooxygenase-2 and microsomal prostaglandin_E synthase .
15090964	0	prostaglandin_E	108,123	cyclooxygenase-2	76,92	prostaglandin E	cyclooxygenase-2	null	29527(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY synthase|amod|END_ENTITY	Burn_injury enhances brain prostaglandin_E2 production through induction of cyclooxygenase-2 and microsomal prostaglandin_E synthase in cerebral vascular endothelial cells in rats .
19018769	0	prostaglandin_E	41,56	cyclooxygenase-2	9,25	prostaglandin E	cyclooxygenase-2	null	19225(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Roles of cyclooxygenase-2 and microsomal prostaglandin_E synthase-1 expression and beta-catenin activation in gastric_carcinogenesis in N-methyl-N-nitrosourea-treated K19-C2mE transgenic_mice .
21957267	0	prostaglandin_E	23,38	cyclooxygenase-2	90,106	prostaglandin E	cyclooxygenase-2	null	5743	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Hemokinin-1 stimulates prostaglandin_E production in human colon through activation of cyclooxygenase-2 and inhibition of 15-hydroxyprostaglandin_dehydrogenase .
15590979	0	prostaglandin_E	111,126	cyclooxygenase-II	69,86	prostaglandin E	cyclooxygenase-II	null	26198(Tax:10116)	Chemical	Gene	synthase|compound|START_ENTITY synthase|compound|END_ENTITY	Vascular_endothelial_growth_factor increases messenger RNAs encoding cyclooxygenase-II and membrane-associated prostaglandin_E synthase in rat luteal cells .
23426368	0	prostaglandin_E	11,26	mPGES2	44,50	prostaglandin E	mPGES2	null	96979(Tax:10090)	Chemical	Gene	type|amod|START_ENTITY type|appos|END_ENTITY	Microsomal prostaglandin_E synthase type 2 -LRB- mPGES2 -RRB- is a glutathione-dependent heme protein , and dithiothreitol dissociates the bound heme to produce active prostaglandin_E2 synthase in vitro .
20522791	0	prostaglandin_E	27,42	miR-146a	8,16	prostaglandin E	miR-146a	null	406938	Chemical	Gene	START_ENTITY|nsubj|increases increases|amod|END_ENTITY	Reduced miR-146a increases prostaglandin_E in chronic_obstructive_pulmonary_disease fibroblasts .
2176076	0	prostaglandin_E	48,63	parathyroid_hormone	11,30	prostaglandin E	parathyroid hormone	null	5741	Chemical	Gene	synthesis|amod|START_ENTITY Effects|nmod|synthesis Effects|nmod|END_ENTITY	Effects of parathyroid_hormone and cytokines on prostaglandin_E synthesis and bone resorption by human periodontal ligament fibroblasts .
19060098	0	prostaglandin_E	70,85	prostacyclin_synthase	97,118	prostaglandin E	prostacyclin synthase	null	25527(Tax:10116)	Chemical	Gene	synthases|amod|START_ENTITY synthases|appos|END_ENTITY	Expression patterns and role of prostaglandin-endoperoxide synthases , prostaglandin_E synthases , prostacyclin_synthase , prostacyclin receptor , peroxisome_proliferator-activated_receptor_delta and retinoid_x_receptor_alpha in rat endometrium during artificially-induced decidualization .
15078866	0	prostaglandin_E	99,114	prostaglandin-endoperoxide_synthase_2	41,78	prostaglandin E	prostaglandin-endoperoxide synthase 2	null	19225(Tax:10090)	Chemical	Gene	synthase|compound|START_ENTITY synthase|amod|END_ENTITY	Prostaglandin_E2 is a product of induced prostaglandin-endoperoxide_synthase_2 and microsomal-type prostaglandin_E synthase at the implantation site of the hamster .
6996018	0	prostaglandin_E	50,65	renin	77,82	prostaglandin E	renin	null	5972	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Effect of propranolol on the urinary excretion of prostaglandin_E and plasma renin activity in hypertensive patients .
7031179	0	prostaglandin_E	6,21	renin	68,73	prostaglandin E	renin	null	5972	Chemical	Gene	START_ENTITY|dep|relationship relationship|acl|END_ENTITY	Renal prostaglandin_E in normal Chinese adults : its relationship to renin activity , sodium and water excretion .
11685297	0	prostaglandin_E1	68,84	C-53	90,94	prostaglandin E1	C-53	MESH:D000527	80279	Chemical	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	A multi-centre , double-blind , placebo-controlled study of liposomal prostaglandin_E1 -LRB- TLC C-53 -RRB- in patients with acute_respiratory_distress_syndrome .
6152434	0	prostaglandin_E1	21,37	E2_and_D2	39,48	prostaglandin E1	E2 and D2	MESH:D000527	299201(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Different effects of prostaglandin_E1 , E2_and_D2 on pancreatic somatostatin release .
3545647	0	prostaglandin_E1	14,30	angiotensin_II	83,97	prostaglandin E1	angiotensin II	MESH:D000527	183	Chemical	Gene	START_ENTITY|nmod|response response|nmod|END_ENTITY	The effect of prostaglandin_E1 upon the pressor and hormonal response to exogenous angiotensin_II in human pregnancy .
9101367	0	prostaglandin_E1	61,77	collagenase-1	28,41	prostaglandin E1	collagenase-1	MESH:D000527	100009110(Tax:9986)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Role of protein kinase A in collagenase-1 gene regulation by prostaglandin_E1 : studies in a rabbit synoviocyte cell line , HIG-82 .
215447	0	prostaglandin_E1	46,62	cyclic_nucleotide_phosphodiesterase	81,116	prostaglandin E1	cyclic nucleotide phosphodiesterase	MESH:D000527	5140	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of sodium_butyrate in combination with prostaglandin_E1 and inhibitors of cyclic_nucleotide_phosphodiesterase on human amelanotic_melanoma cells in culture .
20014600	0	prostaglandin_E1	15,31	interleukin-6	35,48	prostaglandin E1	interleukin-6	MESH:D000527	3569	Chemical	Gene	START_ENTITY|nmod|function function|amod|END_ENTITY	The effects of prostaglandin_E1 on interleukin-6 , pulmonary function and postoperative recovery in oesophagectomised patients .
12595852	0	prostaglandin_E1	12,28	monocyte_chemoattractant_protein-1	37,71	prostaglandin E1	monocyte chemoattractant protein-1	MESH:D000527	6347	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|levels levels|amod|END_ENTITY	Intravenous prostaglandin_E1 reduces monocyte_chemoattractant_protein-1 levels in peripheral arterial_obstructive_disease .
16939916	0	prostaglandin_E1	11,27	monocyte_chemotactic_protein-1	31,61	prostaglandin E1	monocyte chemotactic protein-1	MESH:D000527	24770(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effect of prostaglandin_E1 on monocyte_chemotactic_protein-1 expression in Kupffer cells of rats with hepatic_ischemia-reperfusion_injury -RSB- .
7267829	0	prostaglandin_E1	10,26	parathyroid_hormone	56,75	prostaglandin E1	parathyroid hormone	MESH:D000527	24694(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of prostaglandin_E1 , E2 or indomethacin on serum parathyroid_hormone and calcitonin in the rat .
3042580	0	prostaglandin_E1	37,53	renin	10,15	prostaglandin E1	renin	MESH:D000527	5972	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|END_ENTITY	Increased renin release by exogenous prostaglandin_E1 in liver_cirrhosis with and without ascites .
11579367	0	prostaglandin_E1	12,28	vascular_cell_adhesion_molecule-1	45,78	prostaglandin E1	vascular cell adhesion molecule-1	MESH:D000527	7412	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	Intravenous prostaglandin_E1 reduces soluble vascular_cell_adhesion_molecule-1 in peripheral arterial_obstructive_disease .
10965822	0	prostaglandin_E1	10,26	vascular_endothelial_growth_factor	30,64	prostaglandin E1	vascular endothelial growth factor	MESH:D000527	7422	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Effect of prostaglandin_E1 on vascular_endothelial_growth_factor production by human macrophages and colon_cancer cells .
21334450	0	prostaglandin_E2	95,111	15-PGDH	133,140	prostaglandin E2	15-PGDH	MESH:D015232	15446(Tax:10090)	Chemical	Gene	enzyme|amod|START_ENTITY enzyme|amod|END_ENTITY	Involvement of the constitutive prostaglandin_E synthase cPGES/p23 in expression of an initial prostaglandin_E2 inactivating enzyme , 15-PGDH .
192030	0	prostaglandin_E2	8,24	ACTH	54,58	prostaglandin E2	ACTH	MESH:D015232	403659(Tax:9615)	Chemical	Gene	START_ENTITY|nmod|effect effect|nmod|END_ENTITY	Role of prostaglandin_E2 in the stimulatory effect of ACTH on ovarian blood flow .
2851750	0	prostaglandin_E2	168,184	ACTH	107,111	prostaglandin E2	ACTH	MESH:D015232	5443	Chemical	Gene	vitro|nmod|START_ENTITY release|acl|vitro release|compound|END_ENTITY	Human recombinant interleukin-1_beta_and _ - alpha , but not recombinant tumor_necrosis_factor_alpha stimulate ACTH release from rat anterior pituitary cells in vitro in a prostaglandin_E2 and cAMP independent manner .
21937683	0	prostaglandin_E2	21,37	ANGPTL4	0,7	prostaglandin E2	ANGPTL4	MESH:D015232	51129	Chemical	Gene	induction|nmod|START_ENTITY induction|nummod|END_ENTITY	ANGPTL4 induction by prostaglandin_E2 under hypoxic conditions promotes colorectal_cancer_progression .
8621783	0	prostaglandin_E2	121,137	AT1	99,102	prostaglandin E2	AT1	MESH:D015232	24180(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY production|nummod|END_ENTITY	The subtype-2 -LRB- AT2 -RRB- angiotensin receptor regulates renal cyclic_guanosine_3 ' , _ 5 ' - monophosphate and AT1 receptor-mediated prostaglandin_E2 production in conscious rats .
21169864	0	prostaglandin_E2	69,85	Angiotensin_II	0,14	prostaglandin E2	Angiotensin II	MESH:D015232	24179(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	Angiotensin_II differentially modulates cyclooxygenase-2 , microsomal prostaglandin_E2 synthase-1 and prostaglandin_I2 synthase expression in adventitial fibroblasts exposed to inflammatory stimuli .
6592393	0	prostaglandin_E2	30,46	Angiotensin_II	0,14	prostaglandin E2	Angiotensin II	MESH:D015232	183	Chemical	Gene	formation|amod|START_ENTITY stimulation|nmod|formation stimulation|compound|END_ENTITY	Angiotensin_II stimulation of prostaglandin_E2 and 6-keto-F1 alpha formation by isolated human glomeruli .
2144053	0	prostaglandin_E2	89,105	Atrial_natriuretic_factor	0,25	prostaglandin E2	Atrial natriuretic factor	MESH:D015232	4878	Chemical	Gene	excretion|compound|START_ENTITY excretion|compound|END_ENTITY	Atrial_natriuretic_factor , angiotensin_II , aldosterone , arginine_vasopressin and urinary prostaglandin_E2 excretion in hyperfiltrating unilaterally nephrectomized humans .
3872889	0	prostaglandin_E2	41,57	B_cell_activation	20,37	prostaglandin E2	B cell activation	MESH:D015232	29760	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of human B_cell_activation by prostaglandin_E2 .
1591276	0	prostaglandin_E2	40,56	Bradykinin	0,10	prostaglandin E2	Bradykinin	MESH:D015232	3827	Chemical	Gene	production|nmod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Bradykinin stimulates the production of prostaglandin_E2 and interleukin-6 in human osteoblast-like cells .
2160302	0	prostaglandin_E2	22,38	Bradykinin	0,10	prostaglandin E2	Bradykinin	MESH:D015232	3827	Chemical	Gene	formation|amod|START_ENTITY stimulates|dobj|formation stimulates|nsubj|END_ENTITY	Bradykinin stimulates prostaglandin_E2 formation in isolated human osteoblast-like cells .
20208419	0	prostaglandin_E2	20,36	CD44	52,56	prostaglandin E2	CD44	MESH:D015232	960	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Hyaluronan inhibits prostaglandin_E2 production via CD44 in U937 human macrophages .
11128051	0	prostaglandin_E2	76,92	COX-2	14,19	prostaglandin E2	COX-2	MESH:D015232	26198(Tax:10116)	Chemical	Gene	levels|amod|START_ENTITY levels|amod|selective selective|amod|END_ENTITY	Effect of the COX-2 selective inhibitor l-745 ,337 on inflammation and organ prostaglandin_E2 -LRB- PGE2 -RRB- levels in adjuvant arthritic rats .
11487607	0	prostaglandin_E2	97,113	COX-2	185,190	prostaglandin E2	COX-2	MESH:D015232	29527(Tax:10116)	Chemical	Gene	action|nmod|START_ENTITY mediated|nsubj|action mediated|nmod|inhibition inhibition|nmod|cyclooxygenase-2 cyclooxygenase-2|appos|END_ENTITY	The acute antihyperalgesic action of nonsteroidal , anti-inflammatory drugs and release of spinal prostaglandin_E2 is mediated by the inhibition of constitutive spinal cyclooxygenase-2 -LRB- COX-2 -RRB- but not COX-1 .
12349897	0	prostaglandin_E2	48,64	COX-2	124,129	prostaglandin E2	COX-2	MESH:D015232	5743	Chemical	Gene	release|amod|START_ENTITY mediated|nsubjpass|release mediated|nmod|activation activation|nmod|transcription transcription|appos|END_ENTITY	Tumor_necrosis factor alpha -LRB- TNF-alpha -RRB- - induced prostaglandin_E2 release is mediated by the activation of cyclooxygenase-2 -LRB- COX-2 -RRB- transcription via NFkappaB in human_gingival_fibroblasts .
12846004	0	prostaglandin_E2	57,73	COX-2	42,47	prostaglandin E2	COX-2	MESH:D015232	29527(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY reduces|dobj|production reduces|nsubj|inhibition inhibition|nmod|cyclooxygenase-2 cyclooxygenase-2|appos|END_ENTITY	Selective inhibition of cyclooxygenase-2 -LRB- COX-2 -RRB- reduces prostaglandin_E2 production and attenuates systemic_disease_sequelae in experimental pancreatitis .
16621493	0	prostaglandin_E2	9,25	COX-2	43,48	prostaglandin E2	COX-2	MESH:D015232	26198(Tax:10116)	Chemical	Gene	level|amod|START_ENTITY level|nmod|carcinogenesis carcinogenesis|dep|END_ENTITY	Elevated prostaglandin_E2 level via cPLA2 -- COX-2 -- mPGES-1 pathway involved in bladder carcinogenesis induced by terephthalic_acid-calculi in Wistar_rats .
17085321	0	prostaglandin_E2	106,122	COX-2	81,86	prostaglandin E2	COX-2	MESH:D015232	4513	Chemical	Gene	synthesis|amod|START_ENTITY stimulates|dobj|synthesis stimulates|nsubj|activation activation|nmod|extracellular_signal-regulated_kinase extracellular_signal-regulated_kinase|nmod|END_ENTITY	Concomitant activation of extracellular_signal-regulated_kinase and induction of COX-2 stimulates maximum prostaglandin_E2 synthesis in human airway epithelial cells .
18449498	0	prostaglandin_E2	66,82	COX-2	84,89	prostaglandin E2	COX-2	MESH:D015232	17709(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY production|appos|END_ENTITY	Anti-oxidative and inhibitory activities on nitric_oxide -LRB- NO -RRB- and prostaglandin_E2 -LRB- COX-2 -RRB- production of flavonoids from seeds of Prunus tomentosa Thunberg .
19628768	0	prostaglandin_E2	71,87	COX-2	39,44	prostaglandin E2	COX-2	MESH:D015232	17709(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY activation|nmod|receptor mice|nmod|activation /|dep|mice Rescue|dep|/ Rescue|nmod|healing healing|nmod|END_ENTITY	Rescue of impaired fracture healing in COX-2 - / - mice via activation of prostaglandin_E2 receptor subtype 4 .
22219191	0	prostaglandin_E2	102,118	COX-2	13,18	prostaglandin E2	COX-2	MESH:D015232	5743	Chemical	Gene	production|amod|START_ENTITY control|dobj|production control|nsubj|Induction Induction|nmod|enzyme enzyme|compound|END_ENTITY	Induction of COX-2 enzyme and down-regulation of COX-1 expression by lipopolysaccharide -LRB- LPS -RRB- control prostaglandin_E2 production in astrocytes .
24694755	0	prostaglandin_E2	36,52	COX-2	62,67	prostaglandin E2	COX-2	MESH:D015232	5743	Chemical	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	Genetic variability in key genes in prostaglandin_E2 pathway -LRB- COX-2 , HPGD , ABCC4 and SLCO2A1 -RRB- and their involvement in colorectal_cancer development .
24965577	0	prostaglandin_E2	10,26	COX-2	86,91	prostaglandin E2	COX-2	MESH:D015232	4513	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|survival survival|nmod|expression expression|compound|END_ENTITY	Autocrine prostaglandin_E2 signaling promotes promonocytic_leukemia cell survival via COX-2 expression and MAPK pathway .
25237168	0	prostaglandin_E2	82,98	COX-2	103,108	prostaglandin E2	COX-2	MESH:D015232	5743	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Cyclic compressive loading on 3D tissue of human synovial fibroblasts upregulates prostaglandin_E2 via COX-2 production without IL-1b and TNF-a .
25343626	9	prostaglandin_E2	1309,1325	COX-2	1302,1307	prostaglandin E2	COX-2	MESH:D015232	5743	Chemical	Gene	START_ENTITY|amod|cyclooxygenase-2 cyclooxygenase-2|dep|END_ENTITY	Furthermore , we attribute the TRAIL-resistance and cancer stem cell phenotype observed in tumor spheroids to the upregulation of cyclooxygenase-2 -LRB- COX-2 -RRB- / prostaglandin_E2 -LRB- PGE -RRB- pathway .
25379644	4	prostaglandin_E2	580,596	COX-2	648,653	prostaglandin E2	IL-1b	MESH:D015232	3553	Chemical	Gene	production|amod|START_ENTITY production|acl|suppressing suppressing|dobj|expression expression|appos|END_ENTITY	It also attenuated prostaglandin_E2 -LRB- PGE2 -RRB- production by suppressing cyclooxygenase-2 -LRB- COX-2 -RRB- expression in a concentration-dependent manner -LRB- from 10 M to 80 M -RRB- without affecting cell viability .
27079437	0	prostaglandin_E2	55,71	COX-2	49,54	prostaglandin E2	COX-2	MESH:D015232	5743	Chemical	Gene	Inflammation|dep|START_ENTITY Inflammation|dep|Interplay Interplay|nmod|END_ENTITY	Inflammation in gastric_cancer : Interplay of the COX-2 / prostaglandin_E2 and Toll-like receptor/MyD88 pathways .
9628259	0	prostaglandin_E2	25,41	COX-2	137,142	prostaglandin E2	COX-2	MESH:D015232	5743	Chemical	Gene	production|amod|START_ENTITY increases|dobj|production increases|advcl|enhancing enhancing|dobj|expression expression|amod|cyclooxygenase_2 cyclooxygenase_2|dep|END_ENTITY	Interleukin-13 increases prostaglandin_E2 -LRB- PGE2 -RRB- production by normal human polymorphonuclear neutrophils by enhancing cyclooxygenase_2 -LRB- COX-2 -RRB- gene expression .
16567391	0	prostaglandin_E2	17,33	CXCL1	0,5	prostaglandin E2	CXCL1	MESH:D015232	2919	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	CXCL1 induced by prostaglandin_E2 promotes angiogenesis in colorectal_cancer .
12037188	0	prostaglandin_E2	27,43	Cyclooxygenase-2	0,16	prostaglandin E2	Cyclooxygenase-2	MESH:D015232	5743	Chemical	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Cyclooxygenase-2 regulates prostaglandin_E2 signaling in hippocampal long-term synaptic plasticity .
12445196	0	prostaglandin_E2	44,60	Cyclooxygenase-2	0,16	prostaglandin E2	Cyclooxygenase-2	MESH:D015232	5743	Chemical	Gene	inhibits|nsubj|START_ENTITY enhances|advcl|inhibits enhances|nsubj|inhibitor inhibitor|amod|END_ENTITY	Cyclooxygenase-2 inhibitor enhances whereas prostaglandin_E2 inhibits the production of interferon-induced_protein_of_10_kDa in epidermoid_carcinoma A431 .
12672535	0	prostaglandin_E2	61,77	Cyclooxygenase-2	0,16	prostaglandin E2	Cyclooxygenase-2	MESH:D015232	29527(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY mediates|dobj|release mediates|nsubj|END_ENTITY	Cyclooxygenase-2 mediates platelet-activating factor-induced prostaglandin_E2 release from rat primary astrocytes .
14517215	0	prostaglandin_E2	186,202	Cyclooxygenase-2	0,16	prostaglandin E2	Cyclooxygenase-2	MESH:D015232	5743	Chemical	Gene	loop|nmod|START_ENTITY mediated|nmod|loop mediated|nsubjpass|induction induction|amod|END_ENTITY	Cyclooxygenase-2 induction by bradykinin in human pulmonary artery smooth muscle cells is mediated by the cyclic_AMP response element through a novel autocrine loop involving endogenous prostaglandin_E2 , E-prostanoid_2 -LRB- EP2 -RRB- , and EP4 receptors .
17332329	0	prostaglandin_E2	80,96	Cyclooxygenase-2	0,16	prostaglandin E2	Cyclooxygenase-2	MESH:D015232	19225(Tax:10090)	Chemical	Gene	receptors|amod|START_ENTITY activating|dobj|receptors inhibits|advcl|activating inhibits|nsubj|END_ENTITY	Cyclooxygenase-2 inhibits UVB-induced apoptosis in mouse skin by activating the prostaglandin_E2 receptors , EP2 and EP4 .
17673547	0	prostaglandin_E2	17,33	Cyclooxygenase-2	0,16	prostaglandin E2	Cyclooxygenase-2	MESH:D015232	19225(Tax:10090)	Chemical	Gene	accelerates|nsubj|START_ENTITY END_ENTITY|parataxis|accelerates	Cyclooxygenase-2 / prostaglandin_E2 accelerates the healing of gastric_ulcers via EP4 receptors .
22822059	0	prostaglandin_E2	105,121	Cyclooxygenase-2	0,16	prostaglandin E2	Cyclooxygenase-2	MESH:D015232	5743	Chemical	Gene	production|amod|START_ENTITY mechanism|nmod|production mechanism|nsubj|END_ENTITY	Cyclooxygenase-2 , not microsomal prostaglandin_E synthase-1 , is the mechanism for interleukin-1b-induced prostaglandin_E2 production and inhibition of insulin secretion in pancreatic islets .
21636806	0	prostaglandin_E2	27,43	E-prostanoid_2	44,58	prostaglandin E2	E-prostanoid 2	MESH:D015232	19217(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Targeted disruption of the prostaglandin_E2 E-prostanoid_2 receptor exacerbates vascular neointimal formation in mice .
25327961	0	prostaglandin_E2	12,28	E-prostanoid_2	29,43	prostaglandin E2	E-prostanoid 2	MESH:D015232	19217(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Role of the prostaglandin_E2 / E-prostanoid_2 receptor signalling pathway in TGFb-induced mice mesangial_cell_damage .
7829602	0	prostaglandin_E2	192,208	EGF	70,73	prostaglandin E2	EGF	MESH:D015232	1950	Chemical	Gene	synthesis|amod|START_ENTITY TGF_alpha|nmod|synthesis role|nmod|TGF_alpha Expression|dep|role Expression|nmod|acid acid|appos|END_ENTITY	Expression of messenger ribonucleic acid for epidermal_growth_factor -LRB- EGF -RRB- , transforming_growth_factor-alpha -LRB- TGF_alpha -RRB- , and EGF_receptor in human amnion cells : possible role of TGF_alpha in prostaglandin_E2 synthesis and cell proliferation .
12512025	0	prostaglandin_E2	4,20	EP-1	33,37	prostaglandin E2	EP-1	MESH:D015232	5731	Chemical	Gene	receptor-1|amod|START_ENTITY receptor-1|appos|END_ENTITY	The prostaglandin_E2 receptor-1 -LRB- EP-1 -RRB- mediates_acid-induced visceral_pain hypersensitivity in humans .
10477136	0	prostaglandin_E2	31,47	EP1	66,69	prostaglandin E2	EP1	MESH:D015232	5731	Chemical	Gene	proteins|amod|START_ENTITY Immunolocalization|nmod|proteins Immunolocalization|dep|EP2 EP2|nummod|END_ENTITY	Immunolocalization of the four prostaglandin_E2 receptor proteins EP1 , EP2 , EP3 , and EP4 in human kidney .
11574375	0	prostaglandin_E2	2,18	EP1	36,39	prostaglandin E2	EP1	MESH:D015232	25637(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY subtype|nsubj|receptor subtype|dobj|antagonist antagonist|compound|END_ENTITY	A prostaglandin_E2 receptor subtype EP1 receptor antagonist -LRB- ONO-8711 -RRB- reduces_hyperalgesia , allodynia , and c-fos gene expression in rats with chronic_nerve_constriction .
15612948	0	prostaglandin_E2	106,122	EP1	89,92	prostaglandin E2	EP1	MESH:D015232	5731	Chemical	Gene	receptors|nmod|START_ENTITY receptors|nummod|END_ENTITY	Down-regulation of interleukin-1alpha-induced matrix_metalloproteinase-13 expression via EP1 receptors by prostaglandin_E2 in human periodontal ligament cells .
15855163	0	prostaglandin_E2	25,41	EP1	109,112	prostaglandin E2	EP1	MESH:D015232	5731	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|activation activation|nummod|END_ENTITY	Cyclooxygenase-2-derived prostaglandin_E2 promotes human cholangiocarcinoma cell growth and invasion through EP1 receptor-mediated activation of the epidermal_growth_factor_receptor and Akt .
16172547	0	prostaglandin_E2	19,35	EP1	78,81	prostaglandin E2	EP1	MESH:D015232	25637(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|model model|nmod|esophagitis esophagitis|acl|mediated mediated|nmod|receptors receptors|nummod|END_ENTITY	Biphasic effect of prostaglandin_E2 in a rat model of esophagitis mediated by EP1 receptors : relation to pepsin secretion .
18648380	0	prostaglandin_E2	30,46	EP1	47,50	prostaglandin E2	EP1	MESH:D015232	5731	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|compound|END_ENTITY	The neuroprotective effect of prostaglandin_E2 EP1 receptor inhibition has a wide therapeutic window , is sustained in time and is not sexually dimorphic .
19299433	0	prostaglandin_E2	14,30	EP1	31,34	prostaglandin E2	EP1	MESH:D015232	19216(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Activation of prostaglandin_E2 EP1 receptor increases arteriolar tone and blood pressure in mice with type 2 diabetes .
19389932	0	prostaglandin_E2	115,131	EP1	149,152	prostaglandin E2	EP1	MESH:D015232	19216(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY ablation|nmod|receptor activation|nmod|ablation neurogenesis|nmod|activation Protection|nmod|neurogenesis subtype|nsubj|Protection subtype|dobj|END_ENTITY	Protection of hippocampal neurogenesis from toll-like_receptor_4-dependent innate immune activation by ablation of prostaglandin_E2 receptor subtype EP1 or EP2 .
19625175	0	prostaglandin_E2	19,35	EP1	4,7	prostaglandin E2	EP1	MESH:D015232	5731	Chemical	Gene	receptor|amod|START_ENTITY subtype|nmod|receptor subtype|compound|END_ENTITY	The EP1 subtype of prostaglandin_E2 receptor : role in keratinocyte differentiation and expression in non-melanoma_skin_cancer .
20655707	0	prostaglandin_E2	14,30	EP1	31,34	prostaglandin E2	EP1	MESH:D015232	19216(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Targeting the prostaglandin_E2 EP1 receptor and cyclooxygenase-2 in the amygdala kindling model in mice .
21268127	0	prostaglandin_E2	37,53	EP1	20,23	prostaglandin E2	EP1	MESH:D015232	19216(Tax:10090)	Chemical	Gene	receptor|nmod|START_ENTITY receptor|compound|END_ENTITY	Upregulation of the EP1 receptor for prostaglandin_E2 promotes skin_tumor progression .
21270690	0	prostaglandin_E2	21,37	EP1	55,58	prostaglandin E2	EP1	MESH:D015232	25637(Tax:10116)	Chemical	Gene	antagonist|amod|START_ENTITY antagonist|compound|END_ENTITY	Analgesic effects of prostaglandin_E2 receptor subtype EP1 receptor antagonist : experimental study of application of nucleus pulposus .
21739481	0	prostaglandin_E2	21,37	EP1	4,7	prostaglandin E2	EP1	MESH:D015232	19216(Tax:10090)	Chemical	Gene	receptor|nmod|START_ENTITY receptor|compound|END_ENTITY	The EP1 receptor for prostaglandin_E2 promotes the development and progression of malignant murine skin_tumors .
22110249	0	prostaglandin_E2	12,28	EP1	47,50	prostaglandin E2	EP1	MESH:D015232	5731	Chemical	Gene	START_ENTITY|acl|signaling signaling|nmod|receptors receptors|compound|END_ENTITY	Blockade of prostaglandin_E2 signaling through EP1 and EP3 receptors attenuates Flt3L-dependent dendritic cell development from hematopoietic progenitor cells .
10359563	0	prostaglandin_E2	72,88	EP2	68,71	prostaglandin E2	EP2	MESH:D015232	19217(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Reproductive failure and reduced blood pressure in mice lacking the EP2 prostaglandin_E2 receptor .
10477136	0	prostaglandin_E2	31,47	EP2	71,74	prostaglandin E2	EP4	MESH:D015232	5734	Chemical	Gene	proteins|amod|START_ENTITY Immunolocalization|nmod|proteins Immunolocalization|dep|END_ENTITY	Immunolocalization of the four prostaglandin_E2 receptor proteins EP1 , EP2 , EP3 , and EP4 in human kidney .
10617145	0	prostaglandin_E2	70,86	EP2	107,110	prostaglandin E2	EP2	MESH:D015232	81752(Tax:10116)	Chemical	Gene	reduces|nmod|START_ENTITY reduces|advcl|interfering interfering|nmod|receptors receptors|nummod|END_ENTITY	Protein kinase C activation reduces microglial cyclic_AMP response to prostaglandin_E2 by interfering with EP2 receptors .
12748385	0	prostaglandin_E2	26,42	EP2	3,6	prostaglandin E2	EP2	MESH:D015232	5732	Chemical	Gene	agonist|compound|START_ENTITY agonist|compound|END_ENTITY	An EP2 receptor-selective prostaglandin_E2 agonist induces bone_healing .
12954235	0	prostaglandin_E2	70,86	EP2	28,31	prostaglandin E2	EP2	MESH:D015232	81752(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY essential|nmod|effect essential|nsubj|stimulation stimulation|nmod|END_ENTITY	Simultaneous stimulation of EP2 and EP4 is essential to the effect of prostaglandin_E2 in chondrocyte differentiation .
15113745	0	prostaglandin_E2	32,48	EP2	64,67	prostaglandin E2	EP2	MESH:D015232	19217(Tax:10090)	Chemical	Gene	release|nmod|START_ENTITY Stimulation|nmod|release mediated|nsubjpass|Stimulation mediated|nmod|receptors receptors|compound|END_ENTITY	Stimulation of renin release by prostaglandin_E2 is mediated by EP2 and EP4 receptors in mouse kidneys .
15855407	0	prostaglandin_E2	144,160	EP2	108,111	prostaglandin E2	EP2	MESH:D015232	5732	Chemical	Gene	prostanoid|nmod|START_ENTITY prostanoid|nsubj|regulation regulation|nmod|phosphorylation phosphorylation|nmod|protein protein|nmod|activation activation|nmod|END_ENTITY	Differential regulation of phosphorylation of the cAMP response element-binding protein after activation of EP2 and EP4 prostanoid receptors by prostaglandin_E2 .
15967161	0	prostaglandin_E2	120,136	EP2	101,104	prostaglandin E2	EP2	MESH:D015232	5732	Chemical	Gene	receptor|amod|START_ENTITY subtype|nmod|receptor subtype|compound|END_ENTITY	Regulation of vascular endothelial cell growth factor expression in mouse mammary_tumor cells by the EP2 subtype of the prostaglandin_E2 receptor .
16251433	0	prostaglandin_E2	29,45	EP2	120,123	prostaglandin E2	EP2	MESH:D015232	5732	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|transmission transmission|nmod|receptor receptor|compound|END_ENTITY	Postsynaptically synthesized prostaglandin_E2 -LRB- PGE2 -RRB- modulates hippocampal synaptic transmission via a presynaptic PGE2 EP2 receptor .
16437207	0	prostaglandin_E2	14,30	EP2	50,53	prostaglandin E2	EP2	MESH:D015232	81752(Tax:10116)	Chemical	Gene	subtypes|amod|START_ENTITY subtypes|appos|END_ENTITY	Expression of prostaglandin_E2 receptor subtypes , EP2 and EP4 , in the rat hippocampus after cerebral_ischemia and ischemic tolerance .
16827895	0	prostaglandin_E2	92,108	EP2	16,19	prostaglandin E2	EP2	MESH:D015232	5732	Chemical	Gene	/|nmod|START_ENTITY /|nsubj|E_prostanoid_2 E_prostanoid_2|appos|END_ENTITY	E_prostanoid_2 -LRB- EP2 -RRB- / EP4-mediated suppression of antigen-specific human T-cell responses by prostaglandin_E2 .
17277233	0	prostaglandin_E2	76,92	EP2	23,26	prostaglandin E2	EP2	MESH:D015232	19217(Tax:10090)	Chemical	Gene	responsible|nmod|START_ENTITY responsible|nsubj|END_ENTITY	Prostaglandin receptor EP2 is responsible for cyclooxygenase-2 induction by prostaglandin_E2 in mouse skin .
19233324	0	prostaglandin_E2	90,106	EP2	0,3	prostaglandin E2	EP2	MESH:D015232	81752(Tax:10116)	Chemical	Gene	actions|nmod|START_ENTITY pathways|dobj|actions pathways|nsubj|MAPK MAPK|compound|END_ENTITY	EP2 and EP4 receptors differentially mediate MAPK pathways underlying anabolic actions of prostaglandin_E2 on bone formation in rat calvaria cell cultures .
20664890	0	prostaglandin_E2	28,44	EP2	62,65	prostaglandin E2	EP2	MESH:D015232	5732	Chemical	Gene	receptor|amod|START_ENTITY activation|nmod|receptor subtype|nsubj|activation subtype|ccomp|leads leads|nsubj|END_ENTITY	Selective activation of the prostaglandin_E2 receptor subtype EP2 or EP4 leads to inhibition of platelet_aggregation .
20959465	0	prostaglandin_E2	4,20	EP2	31,34	prostaglandin E2	EP2	MESH:D015232	19217(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	The prostaglandin_E2 receptor , EP2 , stimulates keratinocyte proliferation in mouse skin by G protein-dependent and -LCB- beta -RCB- - arrestin1-dependent signaling pathways .
21268125	0	prostaglandin_E2	4,20	EP2	31,34	prostaglandin E2	EP2	MESH:D015232	19217(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	The prostaglandin_E2 receptor , EP2 , regulates survivin expression via an EGFR/STAT3 pathway in UVB-exposed mouse skin .
22789984	0	prostaglandin_E2	4,20	EP2	31,34	prostaglandin E2	EP2	MESH:D015232	81752(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	The prostaglandin_E2 receptor , EP2 , is upregulated in the dorsal root ganglion after painful cervical facet_joint_injury in the rat .
26034388	0	prostaglandin_E2	14,30	EP2	51,54	prostaglandin E2	EP2	MESH:D015232	5732	Chemical	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Expression of prostaglandin_E2 prostanoid receptor EP2 and interleukin-1b in laryngeal_carcinoma - preliminary study .
8250933	0	prostaglandin_E2	65,81	EP2	30,33	prostaglandin E2	EP2	MESH:D015232	5732	Chemical	Gene	Cloning|nmod|START_ENTITY Cloning|nmod|subtype subtype|compound|END_ENTITY	Cloning and expression of the EP2 subtype of human receptors for prostaglandin_E2 .
8567030	0	prostaglandin_E2	59,75	EP2	31,34	prostaglandin E2	EP2	MESH:D015232	5732	Chemical	Gene	receptors|amod|START_ENTITY subtypes|nmod|receptors subtypes|nsubj|down-regulation down-regulation|nmod|END_ENTITY	Independent down-regulation of EP2 and EP3 subtypes of the prostaglandin_E2 receptors on U937 human monocytic cells .
15619666	0	prostaglandin_E2	19,35	EP2_receptor	97,109	prostaglandin E2	EP2 receptor	MESH:D015232	19217(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|role role|nmod|END_ENTITY	Biphasic effect of prostaglandin_E2 on osteoclast formation in spleen cell cultures : role of the EP2_receptor .
10477136	0	prostaglandin_E2	31,47	EP3	76,79	prostaglandin E2	EP3	MESH:D015232	5733	Chemical	Gene	proteins|amod|START_ENTITY Immunolocalization|nmod|proteins Immunolocalization|dep|EP2 EP2|nummod|END_ENTITY	Immunolocalization of the four prostaglandin_E2 receptor proteins EP1 , EP2 , EP3 , and EP4 in human kidney .
12611496	0	prostaglandin_E2	21,37	EP3	48,51	prostaglandin E2	EP3	MESH:D015232	24929(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	In vitro response of prostaglandin_E2 receptor -LRB- EP3 -RRB- in the term pregnant rat uterus and cervix to misoprostol .
16188227	0	prostaglandin_E2	53,69	EP3	74,77	prostaglandin E2	EP3	MESH:D015232	5733	Chemical	Gene	START_ENTITY|nmod|subtype subtype|compound|END_ENTITY	Rho-kinase mediates spinal nitric_oxide formation by prostaglandin_E2 via EP3 subtype .
16230392	0	prostaglandin_E2	55,71	EP3	38,41	prostaglandin E2	EP3	MESH:D015232	19218(Tax:10090)	Chemical	Gene	results|amod|START_ENTITY receptor|nmod|results receptor|nummod|END_ENTITY	Lack of expression of the EP2 but not EP3 receptor for prostaglandin_E2 results in suppression of skin_tumor development .
17148783	0	prostaglandin_E2	33,49	EP3	94,97	prostaglandin E2	EP3	MESH:D015232	24929(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|role role|nmod|receptor receptor|compound|END_ENTITY	Direct vasoconstrictor effect of prostaglandin_E2 on renal interlobular arteries : role of the EP3 receptor .
17242161	0	prostaglandin_E2	23,39	EP3	110,113	prostaglandin E2	EP3	MESH:D015232	19218(Tax:10090)	Chemical	Gene	exacerbates|nsubj|START_ENTITY exacerbates|nmod|receptors receptors|compound|END_ENTITY	Vascular wall-produced prostaglandin_E2 exacerbates arterial thrombosis and atherothrombosis through platelet EP3 receptors .
19212690	0	prostaglandin_E2	14,30	EP3	110,113	prostaglandin E2	EP3	MESH:D015232	5733	Chemical	Gene	receptors|amod|START_ENTITY Expression|nmod|receptors Expression|nmod|oral_squamous_cell_carcinomas oral_squamous_cell_carcinomas|nmod|antagonist antagonist|compound|END_ENTITY	Expression of prostaglandin_E2 receptors in oral_squamous_cell_carcinomas and growth inhibitory effects of an EP3 selective antagonist , ONO-AE3-240 .
21803432	0	prostaglandin_E2	14,30	EP3	31,34	prostaglandin E2	EP3	MESH:D015232	5733	Chemical	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	Inhibition of prostaglandin_E2 EP3 receptors improves stroke_injury via anti-inflammatory and anti-apoptotic mechanisms .
25865705	0	prostaglandin_E2	102,118	EP3	133,136	prostaglandin E2	EP3	MESH:D015232	5733	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|receptors receptors|compound|END_ENTITY	Exogenous arachidonic_acid mediates permeability of human brain microvessel endothelial cells through prostaglandin_E2 activation of EP3 and EP4 receptors .
25865705	0	prostaglandin_E2	102,118	EP3	133,136	prostaglandin E2	EP3	MESH:D015232	5733	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|receptors receptors|compound|END_ENTITY	Exogenous arachidonic_acid mediates permeability of human brain microvessel endothelial cells through prostaglandin_E2 activation of EP3 and EP4 receptors .
7715741	0	prostaglandin_E2	73,89	EP3	28,31	prostaglandin E2	EP3	MESH:D015232	19218(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY mediate|dobj|effect subtype|xcomp|mediate subtype|nsubj|receptors receptors|nmod|END_ENTITY	Prostanoid receptors of the EP3 subtype mediate the inhibitory effect of prostaglandin_E2 on noradrenaline release in the mouse brain cortex .
7874513	0	prostaglandin_E2	37,53	EP3	120,123	prostaglandin E2	EP3	MESH:D015232	24929(Tax:10116)	Chemical	Gene	injection|nmod|START_ENTITY induces|nsubj|injection induces|parataxis|involvement involvement|nmod|receptors receptors|nummod|END_ENTITY	Intracerebroventricular injection of prostaglandin_E2 induces thermal hyperalgesia in rats : the possible involvement of EP3 receptors .
7981210	0	prostaglandin_E2	37,53	EP3	16,19	prostaglandin E2	EP3	MESH:D015232	5733	Chemical	Gene	receptor|amod|START_ENTITY subtype|nmod|receptor subtype|compound|END_ENTITY	Isoforms of the EP3 subtype of human prostaglandin_E2 receptor transduce both intracellular calcium and cAMP signals .
8910368	0	prostaglandin_E2	127,143	EP3	112,115	prostaglandin E2	EP3	MESH:D015232	5733	Chemical	Gene	receptor|amod|START_ENTITY subtype|nmod|receptor subtype|compound|END_ENTITY	Regulation of expression of matrix_metalloproteinase-9 in early human T cells of the HSB .2 cultured line by the EP3 subtype of prostaglandin_E2 receptor .
9124580	0	prostaglandin_E2	65,81	EP3	91,94	prostaglandin E2	EP3	MESH:D015232	24929(Tax:10116)	Chemical	Gene	subtype|amod|START_ENTITY subtype|compound|END_ENTITY	Prostaglandins induce proliferation of rat hepatocytes through a prostaglandin_E2 receptor EP3 subtype .
9843913	0	prostaglandin_E2	65,81	EP3	47,50	prostaglandin E2	EP3	MESH:D015232	19218(Tax:10090)	Chemical	Gene	receptors|nmod|START_ENTITY receptors|nummod|END_ENTITY	Urinary concentrating function in mice lacking EP3 receptors for prostaglandin_E2 .
8076679	0	prostaglandin_E2	38,54	EP3_beta	71,79	prostaglandin E2	EP3 beta	MESH:D015232	24929(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY receptor|nmod|END_ENTITY	Molecular cloning and expression of a prostaglandin_E2 receptor of the EP3_beta subtype from rat hepatocytes .
10800959	0	prostaglandin_E2	84,100	EP4	25,28	prostaglandin E2	EP4	MESH:D015232	84023(Tax:10116)	Chemical	Gene	action|nmod|START_ENTITY mediating|dobj|action neurons|acl|mediating neurons|nummod|END_ENTITY	A functional analysis of EP4 receptor-expressing neurons in mediating the action of prostaglandin_E2 within specific nuclei of the brain in response to circulating interleukin-1beta .
11444589	0	prostaglandin_E2	64,80	EP4	90,93	prostaglandin E2	EP4	MESH:D015232	5734	Chemical	Gene	subtype|amod|START_ENTITY subtype|compound|END_ENTITY	Molecular cloning and functional characterization of the canine prostaglandin_E2 receptor EP4 subtype .
11597569	0	prostaglandin_E2	41,57	EP4	58,61	prostaglandin E2	EP4	MESH:D015232	5734	Chemical	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Sequestration and phosphorylation of the prostaglandin_E2 EP4 receptor : dependence on the C-terminal tail .
11876748	0	prostaglandin_E2	20,36	EP4	50,53	prostaglandin E2	EP4	MESH:D015232	19219(Tax:10090)	Chemical	Gene	acts|amod|START_ENTITY acts|nmod|receptor receptor|compound|END_ENTITY	Placentally derived prostaglandin_E2 acts via the EP4 receptor to inhibit IL-2-dependent proliferation of CTLL-2 T cells .
11903814	0	prostaglandin_E2	76,92	EP4	28,31	prostaglandin E2	EP4	MESH:D015232	84023(Tax:10116)	Chemical	Gene	actions|nmod|START_ENTITY END_ENTITY|nmod|actions	Involvement of postsynaptic EP4 and presynaptic EP3 receptors in actions of prostaglandin_E2 in rat supraoptic neurones .
12100473	0	prostaglandin_E2	22,38	EP4	18,21	prostaglandin E2	EP4	MESH:D015232	84023(Tax:10116)	Chemical	Gene	subtype|amod|START_ENTITY subtype|compound|END_ENTITY	Expression of the EP4 prostaglandin_E2 receptor subtype with rat dextran sodium_sulphate colitis : colitis suppression by a selective agonist , ONO-AE1-329 .
14751573	0	prostaglandin_E2	122,138	EP4	12,15	prostaglandin E2	EP4	MESH:D015232	84023(Tax:10116)	Chemical	Gene	abrogates|nmod|START_ENTITY abrogates|nsubj|antagonist antagonist|compound|END_ENTITY	A selective EP4 receptor antagonist abrogates the stimulation of osteoblast recruitment from bone marrow stromal cells by prostaglandin_E2 in vivo and in vitro .
15123663	0	prostaglandin_E2	47,63	EP4	64,67	prostaglandin E2	EP4	MESH:D015232	19219(Tax:10090)	Chemical	Gene	activation|amod|START_ENTITY activation|compound|END_ENTITY	Colon_carcinoma cell growth is associated with prostaglandin_E2 / EP4 receptor-evoked ERK activation .
15201706	0	prostaglandin_E2	2,18	EP4	36,39	prostaglandin E2	EP4	MESH:D015232	84023(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY subtype|nsubj|receptor subtype|dobj|cardiovascular_depression cardiovascular_depression|compound|END_ENTITY	A prostaglandin_E2 receptor subtype EP4 agonist attenuates cardiovascular_depression in endotoxin shock by inhibiting inflammatory cytokines and nitric_oxide production .
15336550	0	prostaglandin_E2	47,63	EP4	25,28	prostaglandin E2	EP4	MESH:D015232	19219(Tax:10090)	Chemical	Gene	suppression|amod|START_ENTITY suppression|nummod|END_ENTITY	Microarray evaluation of EP4 receptor-mediated prostaglandin_E2 suppression of 3T3-L1 adipocyte differentiation .
15808664	0	prostaglandin_E2	12,28	EP4	8,11	prostaglandin E2	EP4	MESH:D015232	19219(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Role of EP4 prostaglandin_E2 receptor in the ischemic liver .
15976003	0	prostaglandin_E2	17,33	EP4	34,37	prostaglandin E2	EP4	MESH:D015232	19219(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Dominant role of prostaglandin_E2 EP4 receptor in furosemide-induced salt-losing tubulopathy : a model for hyperprostaglandin_E_syndrome / antenatal_Bartter_syndrome .
17579056	0	prostaglandin_E2	14,30	EP4	31,34	prostaglandin E2	EP4	MESH:D015232	562469(Tax:7955)	Chemical	Gene	Abrogation|nmod|START_ENTITY Abrogation|parataxis|impairs impairs|nsubj|signaling signaling|compound|END_ENTITY	Abrogation of prostaglandin_E2 / EP4 signaling impairs the development of rag1 + lymphoid precursors in the thymus of zebrafish embryos .
17673547	0	prostaglandin_E2	17,33	EP4	80,83	prostaglandin E2	EP4	MESH:D015232	84023(Tax:10116)	Chemical	Gene	accelerates|nsubj|START_ENTITY accelerates|dobj|healing healing|nmod|gastric_ulcers gastric_ulcers|nmod|receptors receptors|nummod|END_ENTITY	Cyclooxygenase-2 / prostaglandin_E2 accelerates the healing of gastric_ulcers via EP4 receptors .
18516068	0	prostaglandin_E2	26,42	EP4	80,83	prostaglandin E2	EP4	MESH:D015232	5734	Chemical	Gene	induced|nmod|START_ENTITY Vasorelaxation|acl|induced Vasorelaxation|dep|role role|nmod|subtype subtype|compound|END_ENTITY	Vasorelaxation induced by prostaglandin_E2 in human pulmonary vein : role of the EP4 receptor subtype .
18849297	0	prostaglandin_E2	73,89	EP4	58,61	prostaglandin E2	EP4	MESH:D015232	5734	Chemical	Gene	receptor|amod|START_ENTITY subtype|nmod|receptor subtype|compound|END_ENTITY	Human_papillomavirus E5 protein induces expression of the EP4 subtype of prostaglandin_E2 receptor in cyclic_AMP response element-dependent pathways in cervical_cancer cells .
19444759	0	prostaglandin_E2	115,131	EP4	61,64	prostaglandin E2	EP4	MESH:D015232	5734	Chemical	Gene	production|nmod|START_ENTITY stimulates|nmod|production stimulates|dobj|expression expression|nmod|END_ENTITY	IL-1beta stimulates the expression of prostaglandin receptor EP4 in human chondrocytes by increasing production of prostaglandin_E2 .
21710489	0	prostaglandin_E2	120,136	EP4	145,148	prostaglandin E2	EP4	MESH:D015232	5734	Chemical	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	Mesenchymal stem cell inhibition of T-helper 17 cell - differentiation is triggered by cell-cell contact and mediated by prostaglandin_E2 via the EP4 receptor .
21898865	0	prostaglandin_E2	11,27	EP4	138,141	prostaglandin E2	EP4	MESH:D015232	5734	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|receptor receptor|compound|END_ENTITY	Endogenous prostaglandin_E2 inhibits aberrant overgrowth of rheumatoid synovial tissue and the development of osteoclast activity through EP4 receptor .
23759445	0	prostaglandin_E2	78,94	EP4	30,33	prostaglandin E2	EP4	MESH:D015232	5734	Chemical	Gene	production|amod|START_ENTITY loop|nmod|production integral|nmod|loop integral|nsubj|END_ENTITY	The prostaglandin_E2 receptor EP4 is integral to a positive feedback loop for prostaglandin_E2 production in human macrophages infected with Mycobacterium_tuberculosis .
23902376	0	prostaglandin_E2	55,71	EP4	0,3	prostaglandin E2	EP4	MESH:D015232	5734	Chemical	Gene	impairs|amod|START_ENTITY A|nmod|impairs activation|nmod|A activation|compound|END_ENTITY	EP4 and EP2 receptor activation of protein kinase A by prostaglandin_E2 impairs macrophage phagocytosis of Clostridium sordellii .
24910202	0	prostaglandin_E2	11,27	EP4	176,179	prostaglandin E2	EP4	MESH:D015232	5734	Chemical	Gene	prolongs|nsubj|START_ENTITY prolongs|advcl|facilitating facilitating|dobj|synthesis synthesis|nmod|receptors receptors|nummod|END_ENTITY	Peripheral prostaglandin_E2 prolongs the sensitization of nociceptive dorsal root ganglion neurons possibly by facilitating the synthesis and anterograde axonal trafficking of EP4 receptors .
25034079	0	prostaglandin_E2	53,69	EP4	36,39	prostaglandin E2	EP4	MESH:D015232	19219(Tax:10090)	Chemical	Gene	promoting|nmod|START_ENTITY promoting|dobj|activity activity|nmod|receptor receptor|compound|END_ENTITY	The tumor promoting activity of the EP4 receptor for prostaglandin_E2 in murine skin .
25063918	0	prostaglandin_E2	24,40	EP4	78,81	prostaglandin E2	EP4	MESH:D015232	5734	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|receptors receptors|nummod|END_ENTITY	Prophylactic effects of prostaglandin_E2 on NSAID-induced enteropathy-role of EP4 receptors in its protective and healing-promoting effects .
26518053	0	prostaglandin_E2	78,94	EP4	39,42	prostaglandin E2	EP4	MESH:D015232	5734	Chemical	Gene	synthesis|amod|START_ENTITY induce|dobj|synthesis induce|nsubj|receptors receptors|compound|END_ENTITY	Prostaglandin_E2-stimulated prostanoid EP4 receptors induce prolonged de novo prostaglandin_E2 synthesis through biphasic phosphorylation of extracellular signal-regulated kinases mediated by activation of protein kinase A in HCA-7 human colon_cancer cells .
27032908	0	prostaglandin_E2	4,20	EP4	21,24	prostaglandin E2	EP4	MESH:D015232	19219(Tax:10090)	Chemical	Gene	START_ENTITY|parataxis|channel channel|nsubj|AMP/T-type AMP/T-type|compound|END_ENTITY	The prostaglandin_E2 / EP4 receptor/cyclic _ AMP/T-type Ca -LRB- 2 + -RRB- channel pathway mediates neuritogenesis in sensory neuron-like ND7/23 cells .
8679543	0	prostaglandin_E2	84,100	EP4	69,72	prostaglandin E2	EP4	MESH:D015232	84023(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY subtype|nmod|receptor subtype|compound|END_ENTITY	Selective regulation of RNK-16 cell matrix metalloproteinases by the EP4 subtype of prostaglandin_E2 receptor .
9203641	0	prostaglandin_E2	46,62	EP4	72,75	prostaglandin E2	EP4	MESH:D015232	5734	Chemical	Gene	subtype|amod|START_ENTITY subtype|compound|END_ENTITY	The long cytoplasmic carboxyl terminus of the prostaglandin_E2 receptor EP4 subtype is essential for agonist-induced desensitization .
15123663	0	prostaglandin_E2	47,63	ERK	84,87	prostaglandin E2	ERK	MESH:D015232	26413(Tax:10090)	Chemical	Gene	activation|amod|START_ENTITY activation|compound|END_ENTITY	Colon_carcinoma cell growth is associated with prostaglandin_E2 / EP4 receptor-evoked ERK activation .
1794340	0	prostaglandin_E2	40,56	Endothelin-1	0,12	prostaglandin E2	Endothelin-1	MESH:D015232	24323(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY stimulate|dobj|secretion END_ENTITY|dep|stimulate	Endothelin-1 and endothelin-3 stimulate prostaglandin_E2 secretion from the rat median eminence .
1850601	0	prostaglandin_E2	24,40	Endothelin-1	0,12	prostaglandin E2	Endothelin-1	MESH:D015232	24323(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Endothelin-1 stimulates prostaglandin_E2 production in an extracellular calcium-independent manner in cultured rat mesangial cells .
26639895	0	prostaglandin_E2	70,86	Ep2	8,11	prostaglandin E2	Ep2	MESH:D015232	19217(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Role Role|nmod|receptors receptors|amod|END_ENTITY	Role of Ep2 and Ep4 receptors in airway microvascular leak induced by prostaglandin_E2 .
3131328	0	prostaglandin_E2	39,55	Epidermal_growth_factor	0,23	prostaglandin E2	Epidermal growth factor	MESH:D015232	1950	Chemical	Gene	biosynthesis|amod|START_ENTITY stimulation|nmod|biosynthesis stimulation|amod|END_ENTITY	Epidermal_growth_factor stimulation of prostaglandin_E2 biosynthesis in amnion cells .
8140119	0	prostaglandin_E2	125,141	Epidermal_growth_factor	0,23	prostaglandin E2	Epidermal growth factor	MESH:D015232	1950	Chemical	Gene	production|amod|START_ENTITY enhance|dobj|production enhance|nsubj|END_ENTITY	Epidermal_growth_factor and transforming_growth_factor-alpha enhance the interleukin-1 - and tumor_necrosis_factor-stimulated prostaglandin_E2 production and the interleukin-1 specific binding on amnion cells .
8951994	0	prostaglandin_E2	60,76	Epidermal_growth_factor	0,23	prostaglandin E2	Epidermal growth factor	MESH:D015232	25313(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|amod|END_ENTITY	Epidermal_growth_factor and glucocorticoid effects on blood prostaglandin_E2 level in DENA-induced carcinogenesis .
9361169	0	prostaglandin_E2	73,89	Epidermal_growth_factor	0,23	prostaglandin E2	Epidermal growth factor	MESH:D015232	1950	Chemical	Gene	derivative|amod|START_ENTITY nocloprost|appos|derivative gastric_ulcer_healing|nmod|nocloprost END_ENTITY|advcl|gastric_ulcer_healing	Epidermal_growth_factor in gastric_ulcer_healing by nocloprost , a stable prostaglandin_E2 derivative .
12598228	0	prostaglandin_E2	22,38	GM-CSF	94,100	prostaglandin E2	GM-CSF	MESH:D015232	12981(Tax:10090)	Chemical	Gene	synthesis|nmod|START_ENTITY synthesis|nmod|END_ENTITY	Impaired synthesis of prostaglandin_E2 by lung fibroblasts and alveolar epithelial cells from GM-CSF - / - mice : implications for fibroproliferation .
10762076	0	prostaglandin_E2	70,86	IL-10	50,55	prostaglandin E2	IL-10	MESH:D015232	16153(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Regulation of macrophage interleukin-6 -LRB- IL-6 -RRB- and IL-10 expression by prostaglandin_E2 : the role of p38 mitogen-activated protein kinase .
7897221	1	prostaglandin_E2	93,109	IL-10	163,168	prostaglandin E2	IL-10	MESH:D015232	16153(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|nmod|mechanism mechanism|acl|involving involving|dobj|END_ENTITY	Colon-26-derived prostaglandin_E2 inhibits TNF-alpha release via a mechanism involving IL-10 .
8018602	0	prostaglandin_E2	15,31	IL-10	0,5	prostaglandin E2	IL-10	MESH:D015232	3586	Chemical	Gene	production|amod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	IL-10 inhibits prostaglandin_E2 production by lipopolysaccharide-stimulated monocytes .
17548652	0	prostaglandin_E2	30,46	IL-23	114,119	prostaglandin E2	IL-23	MESH:D015232	51561	Chemical	Gene	effect|nmod|START_ENTITY mediated|nsubjpass|effect mediated|nmod|END_ENTITY	The proinflammatory effect of prostaglandin_E2 in experimental inflammatory_bowel_disease is mediated through the IL-23 -- > IL-17 axis .
18566439	0	prostaglandin_E2	63,79	IL-23	97,102	prostaglandin E2	IL-23	MESH:D015232	51561	Chemical	Gene	alters|amod|START_ENTITY presence|nmod|alters cells|nmod|presence differentiation|nmod|cells /|nmod|differentiation /|dobj|balance balance|compound|END_ENTITY	In vitro differentiation of dendritic cells in the presence of prostaglandin_E2 alters the IL-12 / IL-23 balance and promotes differentiation of Th17 cells .
8436811	0	prostaglandin_E2	10,26	IL-3	37,41	prostaglandin E2	IL-3	MESH:D015232	16187(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of prostaglandin_E2 -LRB- PGE2 -RRB- on IL-3 / granulocyte-macrophage colony-stimulating factor production by T helper cells .
2553585	0	prostaglandin_E2	20,36	IL-5	116,120	prostaglandin E2	IL-5	MESH:D015232	16191(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|parataxis|END_ENTITY	Different effect of prostaglandin_E2 on B-cell activation by two distinct B-cell differentiation factors , B151-TRF1 / IL-5 and B151-TRF2 : selective inhibition of B151-TRF2-induced antibody response through increases in intracellular cyclic_AMP levels .
11154400	2	prostaglandin_E2	362,378	IL-6	412,416	prostaglandin E2	IL-8	MESH:D015232	3576	Chemical	Gene	beta|amod|START_ENTITY beta|amod|END_ENTITY	Both killed and viable P. _ gingivalis elicited production of prostaglandin_E2 , interleukin-1 beta -LRB- IL-1_beta -RRB- , IL-6 and IL-8 , although killed P. _ gingivalis induced generally higher levels , particularly IL-6 and IL-8 , compared with the viable bacteria .
21475837	0	prostaglandin_E2	44,60	IL-8	17,21	prostaglandin E2	IL-8	MESH:D015232	3576	Chemical	Gene	pathways|amod|START_ENTITY production|nmod|pathways production|compound|END_ENTITY	IL-1b stimulates IL-8 production , including prostaglandin_E2 receptor EP4-triggered pathways , in synoviocyte MH7A cells .
8345201	0	prostaglandin_E2	51,67	IL-8	33,37	prostaglandin E2	IL-8	MESH:D015232	3576	Chemical	Gene	role|nmod|START_ENTITY Regulation|dep|role Regulation|nmod|END_ENTITY	Regulation of neutrophil-derived IL-8 : the role of prostaglandin_E2 , dexamethasone , and IL-4 .
18842581	0	prostaglandin_E2	25,41	Id-1	53,57	prostaglandin E2	Id-1	MESH:D015232	3397	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|transcription transcription|compound|END_ENTITY	Cyclooxygenase-2-derived prostaglandin_E2 stimulates Id-1 transcription .
10376946	0	prostaglandin_E2	51,67	Interferon-gamma	0,16	prostaglandin E2	Interferon-gamma	MESH:D015232	15978(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY reduces|dobj|production reduces|nsubj|END_ENTITY	Interferon-gamma reduces cyclooxygenase-2-mediated prostaglandin_E2 production from primary mouse astrocytes independent of nitric_oxide formation .
6330202	0	prostaglandin_E2	71,87	Interferon-gamma	0,16	prostaglandin E2	Interferon-gamma	MESH:D015232	15978(Tax:10090)	Chemical	Gene	release|amod|START_ENTITY inhibiting|dobj|release reduces|advcl|inhibiting reduces|nsubj|END_ENTITY	Interferon-gamma reduces macrophage-suppressive activity by inhibiting prostaglandin_E2 release and inducing interleukin 1 production .
8354638	0	prostaglandin_E2	84,100	Interferon-gamma	0,16	prostaglandin E2	Interferon-gamma	MESH:D015232	15978(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY Ia|dep|role reduces|nsubj|Ia reduces|dep|END_ENTITY	Interferon-gamma reduces tumor-induced Ia - macrophage-mediated suppression : role of prostaglandin_E2 , _ Ia , _ and_tumor_necrosis_factor-alpha .
2177198	0	prostaglandin_E2	28,44	Interferon_gamma	0,16	prostaglandin E2	Interferon gamma	MESH:D015232	15978(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Interferon_gamma stimulates prostaglandin_E2 production by mouse Kupffer cells .
2138628	0	prostaglandin_E2	121,137	Interleukin-1	0,13	prostaglandin E2	Interleukin-1	MESH:D015232	3552	Chemical	Gene	production|amod|START_ENTITY correlates|nmod|production presence|nmod|correlates regulation|dep|presence regulation|amod|END_ENTITY	Interleukin-1 -LRB- IL-1 -RRB- regulation of human endometrial function : presence of IL-1 receptor correlates with IL-1-stimulated prostaglandin_E2 production .
1641074	0	prostaglandin_E2	74,90	Interleukin-1_beta	0,18	prostaglandin E2	Interleukin-1 beta	MESH:D015232	24494(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY increase|dobj|release increase|dep|END_ENTITY	Interleukin-1_beta and interleukin-6 specifically increase the release of prostaglandin_E2 from rat hypothalamic explants in vitro .
7488646	0	prostaglandin_E2	58,74	Interleukin-1_beta	0,18	prostaglandin E2	Interleukin-1 beta	MESH:D015232	3553	Chemical	Gene	production|nmod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Interleukin-1_beta independently stimulates production of prostaglandin_E2 and cyclic_AMP from human decidual cells .
7615646	0	prostaglandin_E2	110,126	Interleukin-1_beta	0,18	prostaglandin E2	Interleukin-1 beta	MESH:D015232	3553	Chemical	Gene	antagonized|nmod|START_ENTITY antagonized|nsubjpass|induction induction|amod|END_ENTITY	Interleukin-1_beta induction of tissue inhibitor of metalloproteinase -LRB- TIMP-1 -RRB- is functionally antagonized by prostaglandin_E2 in human synovial fibroblasts .
8140125	0	prostaglandin_E2	30,46	Interleukin-1_beta	0,18	prostaglandin E2	Interleukin-1 beta	MESH:D015232	3553	Chemical	Gene	synthesis|amod|START_ENTITY stimulates|dobj|synthesis stimulates|nsubj|END_ENTITY	Interleukin-1_beta stimulates prostaglandin_E2 and F2 alpha synthesis in human ovarian granulosa cells in culture .
8273584	0	prostaglandin_E2	59,75	Interleukin-1_beta	0,18	prostaglandin E2	Interleukin-1 beta	MESH:D015232	3553	Chemical	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Interleukin-1_beta induces cytosolic_PLA2 in parallel with prostaglandin_E2 in rheumatoid synovial fibroblasts .
8866314	0	prostaglandin_E2	20,36	Interleukin-1_beta	0,18	prostaglandin E2	Interleukin-1 beta	MESH:D015232	3553	Chemical	Gene	subclasses|nsubj|START_ENTITY subclasses|advmod|END_ENTITY	Interleukin-1_beta , prostaglandin_E2 , and immunoglobulin G subclasses in gingival crevicular fluid in patients undergoing periodontal therapy .
12529415	0	prostaglandin_E2	62,78	Interleukin-1beta	0,17	prostaglandin E2	Interleukin-1beta	MESH:D015232	3553	Chemical	Gene	pathway|amod|START_ENTITY synthesis|nmod|pathway induces|dobj|synthesis induces|nsubj|END_ENTITY	Interleukin-1beta induces glycosaminoglycan synthesis via the prostaglandin_E2 pathway in cultured human cervical fibroblasts .
8636925	0	prostaglandin_E2	89,105	Interleukin-2	0,13	prostaglandin E2	Interleukin-2	MESH:D015232	3558	Chemical	Gene	release|amod|START_ENTITY implications|nmod|release END_ENTITY|dep|implications	Interleukin-2 in human amniotic_fluid during pregnancy and parturition : implications for prostaglandin_E2 release by fetal membranes .
8164197	0	prostaglandin_E2	25,41	Interleukin-3	0,13	prostaglandin E2	Interleukin-3	MESH:D015232	3562	Chemical	Gene	release|amod|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Interleukin-3 stimulates prostaglandin_E2 release by human fetal membranes at term gestation .
1773338	0	prostaglandin_E2	53,69	Interleukin-6	0,13	prostaglandin E2	Interleukin-6	MESH:D015232	3569	Chemical	Gene	induction|nmod|START_ENTITY END_ENTITY|dep|induction	Interleukin-6 as an endogenous pyrogen : induction of prostaglandin_E2 in brain but not in peripheral blood mononuclear cells .
2362412	0	prostaglandin_E2	79,95	Interleukin-6	0,13	prostaglandin E2	Interleukin-6	MESH:D015232	24498(Tax:10116)	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|production production|amod|END_ENTITY	Interleukin-6 production by endotoxin-stimulated Kupffer cells is regulated by prostaglandin_E2 .
7953976	0	prostaglandin_E2	50,66	Interleukin-6	0,13	prostaglandin E2	Interleukin-6	MESH:D015232	16193(Tax:10090)	Chemical	Gene	mediate|nmod|START_ENTITY mediate|nsubj|END_ENTITY	Interleukin-6 does not mediate the stimulation by prostaglandin_E2 , parathyroid_hormone , or 1,25 _ dihydroxyvitamin_D3 of osteoclast differentiation and bone resorption in neonatal mouse parietal bones .
9556135	0	prostaglandin_E2	35,51	Interleukin-6	0,13	prostaglandin E2	Interleukin-6	MESH:D015232	16193(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY synthesis|acl|induced synthesis|amod|END_ENTITY	Interleukin-6 synthesis induced by prostaglandin_E2 : cross-talk regulation by protein_kinase_C .
1901415	0	prostaglandin_E2	29,45	Interleukin_1_alpha	0,19	prostaglandin E2	Interleukin 1 alpha	MESH:D015232	24493(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY inhibits|dobj|release inhibits|nsubj|END_ENTITY	Interleukin_1_alpha inhibits prostaglandin_E2 release to suppress pulsatile release of luteinizing hormone but not follicle-stimulating hormone .
10225366	0	prostaglandin_E2	18,34	Leptin	0,6	prostaglandin E2	Leptin	MESH:D015232	25608(Tax:10116)	Chemical	Gene	stimulates|dobj|START_ENTITY stimulates|nsubj|END_ENTITY	Leptin stimulates prostaglandin_E2 and F2alpha , but not nitric_oxide production in neonatal rat hypothalamus .
22626465	0	prostaglandin_E2	52,68	MSK1	126,130	prostaglandin E2	MSK1	MESH:D015232	9252	Chemical	Gene	secretion|nmod|START_ENTITY attenuates|dobj|secretion attenuates|advcl|interrupting interrupting|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Astaxanthin attenuates the UVB-induced secretion of prostaglandin_E2 and interleukin-8 in human keratinocytes by interrupting MSK1 phosphorylation in a ROS depletion-independent manner .
16584400	0	prostaglandin_E2	64,80	Multidrug_resistance_associated_protein_2	0,41	prostaglandin E2	Multidrug resistance associated protein 2	MESH:D015232	25303(Tax:10116)	Chemical	Gene	transport|nmod|START_ENTITY mediates|dobj|transport mediates|nsubj|END_ENTITY	Multidrug_resistance_associated_protein_2 mediates transport of prostaglandin_E2 .
2445011	0	prostaglandin_E2	17,33	PO2	10,13	prostaglandin E2	PO2	MESH:D015232	100324027(Tax:9823)	Chemical	Gene	production|amod|START_ENTITY Effect|nmod|production Effect|nmod|END_ENTITY	Effect of PO2 on prostaglandin_E2 production in renal cell cultures .
1332431	0	prostaglandin_E2	47,63	Parathyroid_hormone-related_protein	0,35	prostaglandin E2	Parathyroid hormone-related protein	MESH:D015232	5744	Chemical	Gene	release|amod|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Parathyroid_hormone-related_protein stimulates prostaglandin_E2 release from human osteoblast-like cells : modulating effect of peptide length .
1856269	0	prostaglandin_E2	34,50	Renin	0,5	prostaglandin E2	Renin	MESH:D015232	5972	Chemical	Gene	biosynthesis|nsubj|START_ENTITY increases|ccomp|biosynthesis increases|nsubj|END_ENTITY	Renin increases human amnion cell prostaglandin_E2 biosynthesis .
1414692	0	prostaglandin_E2	10,26	SIN-1	56,61	prostaglandin E2	SIN-1	MESH:D015232	79109	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of prostaglandin_E2 and 3-morpholinosydnonimine -LRB- SIN-1 -RRB- on arachidonic_acid metabolism in fMLP-stimulated rat neutrophils and on thrombin-induced human platelet_aggregation .
7829602	0	prostaglandin_E2	192,208	TGF_alpha	110,119	prostaglandin E2	TGF alpha	MESH:D015232	7039	Chemical	Gene	synthesis|amod|START_ENTITY TGF_alpha|nmod|synthesis role|nmod|TGF_alpha Expression|dep|role Expression|nmod|acid acid|appos|transforming_growth_factor-alpha transforming_growth_factor-alpha|appos|END_ENTITY	Expression of messenger ribonucleic acid for epidermal_growth_factor -LRB- EGF -RRB- , transforming_growth_factor-alpha -LRB- TGF_alpha -RRB- , and EGF_receptor in human amnion cells : possible role of TGF_alpha in prostaglandin_E2 synthesis and cell proliferation .
7829602	0	prostaglandin_E2	192,208	TGF_alpha	179,188	prostaglandin E2	TGF alpha	MESH:D015232	7039	Chemical	Gene	synthesis|amod|START_ENTITY END_ENTITY|nmod|synthesis	Expression of messenger ribonucleic acid for epidermal_growth_factor -LRB- EGF -RRB- , transforming_growth_factor-alpha -LRB- TGF_alpha -RRB- , and EGF_receptor in human amnion cells : possible role of TGF_alpha in prostaglandin_E2 synthesis and cell proliferation .
20637112	0	prostaglandin_E2	12,28	TLR4	62,66	prostaglandin E2	TLR4	MESH:D015232	21898(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|receptor receptor|appos|END_ENTITY	The role of prostaglandin_E2 -LRB- PGE_2 -RRB- in toll-like receptor 4 -LRB- TLR4 -RRB- - mediated colitis-associated_neoplasia .
12349897	0	prostaglandin_E2	48,64	TNF-alpha	29,38	prostaglandin E2	TNF-alpha	MESH:D015232	7124	Chemical	Gene	release|amod|START_ENTITY mediated|nsubjpass|release induced|ccomp|mediated alpha|acl|induced alpha|appos|END_ENTITY	Tumor_necrosis factor alpha -LRB- TNF-alpha -RRB- - induced prostaglandin_E2 release is mediated by the activation of cyclooxygenase-2 -LRB- COX-2 -RRB- transcription via NFkappaB in human_gingival_fibroblasts .
7897221	1	prostaglandin_E2	93,109	TNF-alpha	119,128	prostaglandin E2	TNF-alpha	MESH:D015232	21926(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|amod|END_ENTITY	Colon-26-derived prostaglandin_E2 inhibits TNF-alpha release via a mechanism involving IL-10 .
9743553	0	prostaglandin_E2	98,114	TNF-alpha	39,48	prostaglandin E2	TNF-alpha	MESH:D015232	7124	Chemical	Gene	role|nmod|START_ENTITY kinase|nsubj|role inhibitor|parataxis|kinase inhibitor|amod|END_ENTITY	A carbocyclic_nucleoside analogue is a TNF-alpha inhibitor with immunosuppressive action : role of prostaglandin_E2 and protein kinase C and comparison with pentoxifylline .
8447405	0	prostaglandin_E2	28,44	TRH	64,67	prostaglandin E2	TRH	MESH:D015232	25569(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY release|nsubj|regulation release|nmod|END_ENTITY	Vagal regulation of gastric prostaglandin_E2 release by central TRH in rats .
16929493	0	prostaglandin_E2	41,57	Thioredoxin-related_protein-1	0,29	prostaglandin E2	Thioredoxin-related protein-1	MESH:D015232	9352	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|END_ENTITY	Thioredoxin-related_protein-1 induced by prostaglandin_E2 .
9141614	0	prostaglandin_E2	28,44	Thrombin	0,8	prostaglandin E2	Thrombin	MESH:D015232	2147	Chemical	Gene	synthesis|amod|START_ENTITY synthesis|compound|END_ENTITY	Thrombin receptor-dependent prostaglandin_E2 synthesis in hamster fibroblasts : synergistic interactions with interleukin-1beta .
8897887	0	prostaglandin_E2	89,105	Tumor_necrosis_factor-alpha	0,27	prostaglandin E2	Tumor necrosis factor-alpha	MESH:D015232	7124	Chemical	Gene	driven|nmod|START_ENTITY colon|acl|driven secretion|nmod|colon Cl|dep|secretion Cl|compound|END_ENTITY	Tumor_necrosis_factor-alpha induces Cl - _ and_K + secretion in human distal colon driven by prostaglandin_E2 .
12727858	0	prostaglandin_E2	84,100	Vascular_endothelial_growth_factor	0,34	prostaglandin E2	Vascular endothelial growth factor	MESH:D015232	7422	Chemical	Gene	exposed|nmod|START_ENTITY cells|acl|exposed expression|nmod|cells expression|amod|END_ENTITY	Vascular_endothelial_growth_factor gene expression in colon_cancer cells exposed to prostaglandin_E2 is mediated by hypoxia-inducible_factor_1 .
15970595	0	prostaglandin_E2	48,64	Vascular_endothelial_growth_factor	0,34	prostaglandin E2	Vascular endothelial growth factor	MESH:D015232	7422	Chemical	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Vascular_endothelial_growth_factor induction by prostaglandin_E2 in human airway smooth muscle cells is mediated by E prostanoid EP2/EP4 receptors and SP-1 transcription factor binding sites .
25333935	0	prostaglandin_E2	106,122	Vascular_endothelial_growth_factor	0,34	prostaglandin E2	Vascular endothelial growth factor	MESH:D015232	22339(Tax:10090)	Chemical	Gene	niche|nmod|START_ENTITY formation|nmod|niche role|nmod|formation plays|dobj|role plays|nsubj|END_ENTITY	Vascular_endothelial_growth_factor plays a critical role in the formation of the pre-metastatic niche via prostaglandin_E2 .
20194308	0	prostaglandin_E2	25,41	angiotensin_II	120,134	prostaglandin E2	angiotensin II	MESH:D015232	11606(Tax:10090)	Chemical	Gene	required|nsubjpass|START_ENTITY required|nmod|cerebrovascular_dysfunction cerebrovascular_dysfunction|acl|induced induced|nmod|END_ENTITY	Cyclooxygenase_1-derived prostaglandin_E2 and EP1 receptors are required for the cerebrovascular_dysfunction induced by angiotensin_II .
2113380	0	prostaglandin_E2	100,116	angiotensin_II	51,65	prostaglandin E2	angiotensin II	MESH:D015232	24179(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY synthesis|amod|END_ENTITY	Interleukin_1_and_tumor_necrosis_factor potentiate angiotensin_II - and calcium ionophore-stimulated prostaglandin_E2 synthesis in rat renal mesangial cells .
2268285	0	prostaglandin_E2	152,168	angiotensin_II	77,91	prostaglandin E2	angiotensin II	MESH:D015232	183	Chemical	Gene	attenuated|nmod|START_ENTITY attenuated|nsubjpass|contractility contractility|nmod|cells cells|nmod|response response|nmod|factor factor|amod|END_ENTITY	Insulin-dependent contractility of glomerular mesangial cells in response to angiotensin_II , platelet-activating factor and endothelin is attenuated by prostaglandin_E2 .
3036706	0	prostaglandin_E2	65,81	angiotensin_II	24,38	prostaglandin E2	angiotensin II	MESH:D015232	24179(Tax:10116)	Chemical	Gene	alter|dobj|START_ENTITY alter|nsubj|infusions infusions|nmod|END_ENTITY	Subpressor infusions of angiotensin_II alter glomerular binding , prostaglandin_E2 , and cyclic_AMP production .
3284821	0	prostaglandin_E2	32,48	angiotensin_II	8,22	prostaglandin E2	angiotensin II	MESH:D015232	183	Chemical	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	Role of angiotensin_II in renal prostaglandin_E2 production after furosemide administration .
6365409	0	prostaglandin_E2	14,30	angiotensin_II	72,86	prostaglandin E2	angiotensin II	MESH:D015232	183	Chemical	Gene	START_ENTITY|nmod|response response|nmod|END_ENTITY	The effect of prostaglandin_E2 upon the biochemical response to infused angiotensin_II in human pregnancy .
8023965	0	prostaglandin_E2	81,97	angiotensin_II	50,64	prostaglandin E2	angiotensin II	MESH:D015232	24179(Tax:10116)	Chemical	Gene	modulated|nmod|START_ENTITY modulated|nsubjpass|Vasoconstriction Vasoconstriction|nmod|recta recta|nmod|END_ENTITY	Vasoconstriction of outer medullary vasa recta by angiotensin_II is modulated by prostaglandin_E2 .
913046	0	prostaglandin_E2	161,177	angiotensin_II	134,148	prostaglandin E2	angiotensin II	MESH:D015232	24179(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY Potentiation|dep|effects Potentiation|nmod|effects effects|nmod|ions ions|nmod|arteries arteries|nmod|concentrations concentrations|nmod|END_ENTITY	Potentiation of pressor effects of noradrenaline and potassium ions in the rat mesenteric arteries by physiological concentrations of angiotensin_II : effects of prostaglandin_E2 and cortisol .
2683790	0	prostaglandin_E2	20,36	antidiuretic_hormone	47,67	prostaglandin E2	antidiuretic hormone	MESH:D015232	551	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of exogenous prostaglandin_E2 on plasma antidiuretic_hormone in normal man .
7263837	0	prostaglandin_E2	48,64	antidiuretic_hormone	16,36	prostaglandin E2	antidiuretic hormone	MESH:D015232	551	Chemical	Gene	excretion|amod|START_ENTITY effects|nmod|excretion effects|nmod|END_ENTITY	Dual effects of antidiuretic_hormone on urinary prostaglandin_E2 excretion in man .
18199552	0	prostaglandin_E2	25,41	beta-catenin	52,64	prostaglandin E2	beta-catenin	MESH:D015232	1499	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Cyclooxygenase-2-derived prostaglandin_E2 activates beta-catenin in human cholangiocarcinoma cells : evidence for inhibition of these signaling pathways by omega_3_polyunsaturated_fatty_acids .
19169646	0	prostaglandin_E2	54,70	beta1-integrin	25,39	prostaglandin E2	beta1-integrin	MESH:D015232	3688	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Enhancement of activated beta1-integrin expression by prostaglandin_E2 via EP receptors in isolated human coronary arterial endothelial cells : implication for the treatment of Kawasaki_disease .
15254968	0	prostaglandin_E2	68,84	bone_morphogenetic_protein-2	14,42	prostaglandin E2	bone morphogenetic protein-2	MESH:D015232	650	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of bone_morphogenetic_protein-2 expression by endogenous prostaglandin_E2 in human mesenchymal stem cells .
15468368	0	prostaglandin_E2	37,53	calcitonin_gene-related_peptide	68,99	prostaglandin E2	calcitonin gene-related peptide	MESH:D015232	12310(Tax:10090)	Chemical	Gene	release|amod|START_ENTITY release|amod|END_ENTITY	Osteoarthritic mice exhibit enhanced prostaglandin_E2 and unchanged calcitonin_gene-related_peptide release in a novel isolated knee joint model .
9407310	0	prostaglandin_E2	52,68	connexin43	14,24	prostaglandin E2	connexin43	MESH:D015232	24392(Tax:10116)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of connexin43 expression and function by prostaglandin_E2 -LRB- PGE2 -RRB- and parathyroid_hormone -LRB- PTH -RRB- in osteoblastic cells .
15077295	0	prostaglandin_E2	25,41	corticotropin-releasing_hormone	56,87	prostaglandin E2	corticotropin-releasing hormone	MESH:D015232	1392	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Cyclooxygenase_2-derived prostaglandin_E2 production by corticotropin-releasing_hormone contributes to the activated cAMP_response_element_binding_protein content in rheumatoid_arthritis synovial tissue .
10027847	0	prostaglandin_E2	14,30	cyclooxygenase-2	66,82	prostaglandin E2	cyclooxygenase-2	MESH:D015232	5743	Chemical	Gene	release|amod|START_ENTITY release|nmod|cells cells|acl|expressing expressing|xcomp|END_ENTITY	Mechanisms of prostaglandin_E2 release by intact cells expressing cyclooxygenase-2 : evidence for a ` two-component ' model .
10079177	0	prostaglandin_E2	51,67	cyclooxygenase-2	100,116	prostaglandin E2	cyclooxygenase-2	MESH:D015232	19225(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY production|nmod|induction induction|nmod|mRNA mRNA|amod|END_ENTITY	Low intensity pulsed ultrasound exposure increases prostaglandin_E2 production via the induction of cyclooxygenase-2 mRNA in mouse osteoblasts .
10807497	0	prostaglandin_E2	10,26	cyclooxygenase-2	135,151	prostaglandin E2	cyclooxygenase-2	MESH:D015232	29527(Tax:10116)	Chemical	Gene	generation|amod|START_ENTITY generation|nmod|cells cells|amod|END_ENTITY	Augmented prostaglandin_E2 generation resulting from increased activities of cytosolic and secretory phospholipase A2 and induction of cyclooxygenase-2 in interleukin-1_beta-stimulated rat calvarial cells during the mineralizing phase .
10815617	0	prostaglandin_E2	88,104	cyclooxygenase-2	17,33	prostaglandin E2	cyclooxygenase-2	MESH:D015232	5743	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|induction induction|nmod|cells cells|amod|END_ENTITY	The induction of cyclooxygenase-2 in IL-1beta-treated endothelial cells is inhibited by prostaglandin_E2 through cAMP .
10869354	0	prostaglandin_E2	14,30	cyclooxygenase-2	129,145	prostaglandin E2	cyclooxygenase-2	MESH:D015232	5743	Chemical	Gene	biosynthesis|amod|START_ENTITY Regulation|nmod|biosynthesis synthase|nsubj|Regulation synthase|ccomp|acts acts|advcl|END_ENTITY	Regulation of prostaglandin_E2 biosynthesis by inducible membrane-associated prostaglandin_E2 synthase that acts in concert with cyclooxygenase-2 .
10869354	0	prostaglandin_E2	77,93	cyclooxygenase-2	129,145	prostaglandin E2	cyclooxygenase-2	MESH:D015232	5743	Chemical	Gene	biosynthesis|nmod|START_ENTITY Regulation|nmod|biosynthesis synthase|nsubj|Regulation synthase|ccomp|acts acts|advcl|END_ENTITY	Regulation of prostaglandin_E2 biosynthesis by inducible membrane-associated prostaglandin_E2 synthase that acts in concert with cyclooxygenase-2 .
10975859	0	prostaglandin_E2	113,129	cyclooxygenase-2	151,167	prostaglandin E2	cyclooxygenase-2	MESH:D015232	5743	Chemical	Gene	START_ENTITY|nmod|induction induction|nmod|END_ENTITY	The induction of cell death in human osteoarthritis chondrocytes by nitric_oxide is related to the production of prostaglandin_E2 via the induction of cyclooxygenase-2 .
11076710	0	prostaglandin_E2	31,47	cyclooxygenase-2	75,91	prostaglandin E2	cyclooxygenase-2	MESH:D015232	5743	Chemical	Gene	relationship|nmod|START_ENTITY relationship|amod|END_ENTITY	Inverse relationship of plasma prostaglandin_E2 and blood mononuclear cell cyclooxygenase-2 with disease severity in children with Plasmodium_falciparum malaria .
11140899	0	prostaglandin_E2	124,140	cyclooxygenase-2	23,39	prostaglandin E2	cyclooxygenase-2	MESH:D015232	5743	Chemical	Gene	production|amod|START_ENTITY inhibition|nmod|production inhibition|nmod|results results|amod|END_ENTITY	Specific inhibition of cyclooxygenase-2 results in inhibition of proliferation of oral_cancer cell lines via suppression of prostaglandin_E2 production .
11487607	0	prostaglandin_E2	97,113	cyclooxygenase-2	167,183	prostaglandin E2	cyclooxygenase-2	MESH:D015232	29527(Tax:10116)	Chemical	Gene	action|nmod|START_ENTITY mediated|nsubj|action mediated|nmod|inhibition inhibition|nmod|END_ENTITY	The acute antihyperalgesic action of nonsteroidal , anti-inflammatory drugs and release of spinal prostaglandin_E2 is mediated by the inhibition of constitutive spinal cyclooxygenase-2 -LRB- COX-2 -RRB- but not COX-1 .
12349897	0	prostaglandin_E2	48,64	cyclooxygenase-2	106,122	prostaglandin E2	cyclooxygenase-2	MESH:D015232	5743	Chemical	Gene	release|amod|START_ENTITY mediated|nsubjpass|release mediated|nmod|activation activation|nmod|transcription transcription|amod|END_ENTITY	Tumor_necrosis factor alpha -LRB- TNF-alpha -RRB- - induced prostaglandin_E2 release is mediated by the activation of cyclooxygenase-2 -LRB- COX-2 -RRB- transcription via NFkappaB in human_gingival_fibroblasts .
12593597	0	prostaglandin_E2	78,94	cyclooxygenase-2	21,37	prostaglandin E2	cyclooxygenase-2	MESH:D015232	5743	Chemical	Gene	levels|nmod|START_ENTITY Effects|nmod|levels Effects|nmod|inhibition inhibition|amod|END_ENTITY	Effects of selective cyclooxygenase-2 inhibition on gingival_tissue levels of prostaglandin_E2 and prostaglandin_F2alpha and clinical parameters of chronic_periodontitis .
12846004	0	prostaglandin_E2	57,73	cyclooxygenase-2	24,40	prostaglandin E2	cyclooxygenase-2	MESH:D015232	29527(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY reduces|dobj|production reduces|nsubj|inhibition inhibition|nmod|END_ENTITY	Selective inhibition of cyclooxygenase-2 -LRB- COX-2 -RRB- reduces prostaglandin_E2 production and attenuates systemic_disease_sequelae in experimental pancreatitis .
15090964	0	prostaglandin_E2	27,43	cyclooxygenase-2	76,92	prostaglandin E2	cyclooxygenase-2	MESH:D015232	29527(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY production|nmod|induction induction|nmod|synthase synthase|amod|END_ENTITY	Burn_injury enhances brain prostaglandin_E2 production through induction of cyclooxygenase-2 and microsomal prostaglandin_E synthase in cerebral vascular endothelial cells in rats .
15234907	0	prostaglandin_E2	56,72	cyclooxygenase-2	24,40	prostaglandin E2	cyclooxygenase-2	MESH:D015232	5743	Chemical	Gene	synthase|amod|START_ENTITY synthase|amod|END_ENTITY	Cigarette smoke induces cyclooxygenase-2 and microsomal prostaglandin_E2 synthase in human lung fibroblasts : implications for lung_inflammation and cancer .
15364005	0	prostaglandin_E2	66,82	cyclooxygenase-2	14,30	prostaglandin E2	cyclooxygenase-2	MESH:D015232	29527(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY reduces|dobj|secretion reduces|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of cyclooxygenase-2 , but not cyclooxygenase-1 , reduces prostaglandin_E2 secretion from diabetic rat retinas .
16014934	0	prostaglandin_E2	94,110	cyclooxygenase-2	47,63	prostaglandin E2	cyclooxygenase-2	MESH:D015232	5743	Chemical	Gene	role|nmod|START_ENTITY expression|dep|role expression|nmod|END_ENTITY	Hepatitis_C virus stimulates the expression of cyclooxygenase-2 via oxidative stress : role of prostaglandin_E2 in RNA replication .
16580130	0	prostaglandin_E2	103,119	cyclooxygenase-2	141,157	prostaglandin E2	cyclooxygenase-2	MESH:D015232	29527(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY induced|dobj|release induced|nmod|activation activation|nmod|END_ENTITY	The long-term exposure of rat cultured dorsal root ganglion cells to bradykinin induced the release of prostaglandin_E2 by the activation of cyclooxygenase-2 .
17277233	0	prostaglandin_E2	76,92	cyclooxygenase-2	46,62	prostaglandin E2	cyclooxygenase-2	MESH:D015232	19225(Tax:10090)	Chemical	Gene	responsible|nmod|START_ENTITY responsible|nmod|induction induction|amod|END_ENTITY	Prostaglandin receptor EP2 is responsible for cyclooxygenase-2 induction by prostaglandin_E2 in mouse skin .
17342254	0	prostaglandin_E2	63,79	cyclooxygenase-2	98,114	prostaglandin E2	cyclooxygenase-2	MESH:D015232	5743	Chemical	Gene	production|nmod|START_ENTITY enhances|dobj|production enhances|nmod|increase increase|nmod|expression expression|amod|END_ENTITY	Lipopolysaccharide enhances the production of nicotine-induced prostaglandin_E2 by an increase in cyclooxygenase-2 expression in osteoblasts .
18183617	0	prostaglandin_E2	23,39	cyclooxygenase-2	83,99	prostaglandin E2	cyclooxygenase-2	MESH:D015232	29527(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY enhances|dobj|production enhances|nmod|expression expression|nmod|microglia microglia|amod|END_ENTITY	Retinoic_acid enhances prostaglandin_E2 production through increased expression of cyclooxygenase-2 and microsomal prostaglandin_E synthase-1 in rat brain microglia .
19244345	0	prostaglandin_E2	123,139	cyclooxygenase-2	35,51	prostaglandin E2	cyclooxygenase-2	MESH:D015232	5743	Chemical	Gene	production|amod|START_ENTITY reduced|iobj|production reduced|nsubj|suppression suppression|nmod|END_ENTITY	Caveolin-1-mediated suppression of cyclooxygenase-2 via a beta-catenin-Tcf/Lef-dependent transcriptional mechanism reduced prostaglandin_E2 production and survivin expression .
20838026	0	prostaglandin_E2	64,80	cyclooxygenase-2	107,123	prostaglandin E2	cyclooxygenase-2	MESH:D015232	5743	Chemical	Gene	production|amod|START_ENTITY Inhibits|dobj|production Inhibits|advcl|suppressing suppressing|dobj|upregulation upregulation|amod|END_ENTITY	Curcumin Inhibits the proteinase-activated_receptor-2-triggered prostaglandin_E2 production by suppressing cyclooxygenase-2 upregulation and Akt-dependent activation of nuclear factor-kB in human lung epithelial cells .
21169864	0	prostaglandin_E2	69,85	cyclooxygenase-2	40,56	prostaglandin E2	cyclooxygenase-2	MESH:D015232	29527(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Angiotensin_II differentially modulates cyclooxygenase-2 , microsomal prostaglandin_E2 synthase-1 and prostaglandin_I2 synthase expression in adventitial fibroblasts exposed to inflammatory stimuli .
22113581	0	prostaglandin_E2	91,107	cyclooxygenase-2	147,163	prostaglandin E2	cyclooxygenase-2	MESH:D015232	5743	Chemical	Gene	synthesis|amod|START_ENTITY synthesis|nmod|suppression suppression|nmod|END_ENTITY	A curcumin derivative , 2,6-bis -LRB- 2,5-dimethoxybenzylidene -RRB- - cyclohexanone -LRB- BDMC33 -RRB- attenuates prostaglandin_E2 synthesis via selective suppression of cyclooxygenase-2 in IFN-y/LPS-stimulated macrophages .
23973650	0	prostaglandin_E2	44,60	cyclooxygenase-2	13,29	prostaglandin E2	cyclooxygenase-2	MESH:D015232	5743	Chemical	Gene	stimulation|amod|START_ENTITY Induction|nmod|stimulation Induction|nmod|expression expression|amod|END_ENTITY	Induction of cyclooxygenase-2 expression by prostaglandin_E2 stimulation of the prostanoid_EP4_receptor via coupling to Gai and transactivation of the epidermal_growth_factor_receptor in HCA-7 human colon_cancer cells .
24376609	0	prostaglandin_E2	18,34	cyclooxygenase-2	65,81	prostaglandin E2	cyclooxygenase-2	MESH:D015232	19225(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY stimulates|dobj|production stimulates|nmod|macrophages macrophages|nmod|A2 A2|amod|END_ENTITY	Bisgma stimulates prostaglandin_E2 production in macrophages via cyclooxygenase-2 , cytosolic phospholipase A2 , and mitogen-activated protein kinases family .
24946563	0	prostaglandin_E2	81,97	cyclooxygenase-2	63,79	prostaglandin E2	cyclooxygenase-2	MESH:D015232	5743	Chemical	Gene	axis|amod|START_ENTITY axis|amod|END_ENTITY	-LSB- Triptolide inhibites Th17 cell differentiation via regulating cyclooxygenase-2 / prostaglandin_E2 axis in synovial fibroblasts from rheumatoid_arthritis -RSB- .
25777050	0	prostaglandin_E2	181,197	cyclooxygenase-2	12,28	prostaglandin E2	cyclooxygenase-2	MESH:D015232	5743	Chemical	Gene	B2|amod|START_ENTITY quantification|nmod|B2 extraction-liquid|nmod|quantification extraction-liquid|csubj|Determining Determining|dobj|activity activity|amod|END_ENTITY	Determining cyclooxygenase-2 activity in three different test systems utilizing online-solid phase extraction-liquid chromatography-mass spectrometry for parallel quantification of prostaglandin_E2 , D2 and thromboxane B2 .
7873203	0	prostaglandin_E2	78,94	cyclooxygenase-2	13,29	prostaglandin E2	cyclooxygenase-2	MESH:D015232	5743	Chemical	Gene	synthesis|amod|START_ENTITY responsible|nmod|synthesis responsible|nsubj|Induction Induction|nmod|END_ENTITY	Induction of cyclooxygenase-2 is responsible for interleukin-1_beta-dependent prostaglandin_E2 synthesis by human lung fibroblasts .
8643498	0	prostaglandin_E2	37,53	cyclooxygenase-2	106,122	prostaglandin E2	cyclooxygenase-2	MESH:D015232	19225(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|model model|dep|role role|nmod|END_ENTITY	Elevated interleukin_6 is induced by prostaglandin_E2 in a murine model of inflammation : possible role of cyclooxygenase-2 .
8937452	0	prostaglandin_E2	37,53	cyclooxygenase-2	80,96	prostaglandin E2	cyclooxygenase-2	MESH:D015232	442942(Tax:9615)	Chemical	Gene	synthesis|amod|START_ENTITY corticosteroids|nmod|synthesis Interference|nmod|corticosteroids Interference|nmod|level level|nmod|expression expression|amod|END_ENTITY	Interference of corticosteroids with prostaglandin_E2 synthesis at the level of cyclooxygenase-2 mRNA expression in kidney cells .
9014225	0	prostaglandin_E2	52,68	cyclooxygenase-2	83,99	prostaglandin E2	cyclooxygenase-2	MESH:D015232	29527(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY production|nmod|macrophages macrophages|amod|END_ENTITY	Effects of non-steroidal anti-inflammatory drugs on prostaglandin_E2 production by cyclooxygenase-2 from endogenous and exogenous arachidonic_acid in rat peritoneal macrophages stimulated with lipopolysaccharide .
9020023	0	prostaglandin_E2	105,121	cyclooxygenase-2	55,71	prostaglandin E2	cyclooxygenase-2	MESH:D015232	29527(Tax:10116)	Chemical	Gene	production|nmod|START_ENTITY leads|nmod|production leads|nsubj|induction induction|nmod|synthase synthase|nmod|END_ENTITY	Concordant induction of prostaglandin_E2 synthase with cyclooxygenase-2 leads to preferred production of prostaglandin_E2 over thromboxane and prostaglandin_D2 in lipopolysaccharide-stimulated rat peritoneal macrophages .
9020023	0	prostaglandin_E2	24,40	cyclooxygenase-2	55,71	prostaglandin E2	cyclooxygenase-2	MESH:D015232	29527(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY synthase|nmod|END_ENTITY	Concordant induction of prostaglandin_E2 synthase with cyclooxygenase-2 leads to preferred production of prostaglandin_E2 over thromboxane and prostaglandin_D2 in lipopolysaccharide-stimulated rat peritoneal macrophages .
9105400	0	prostaglandin_E2	70,86	cyclooxygenase-2	50,66	prostaglandin E2	cyclooxygenase-2	MESH:D015232	19225(Tax:10090)	Chemical	Gene	cyclic_AMP|amod|START_ENTITY END_ENTITY|nmod|cyclic_AMP	Repression of inducible_nitric_oxide_synthase and cyclooxygenase-2 by prostaglandin_E2 and other cyclic_AMP stimulants in J774 macrophages .
9182946	0	prostaglandin_E2	70,86	cyclooxygenase-2	17,33	prostaglandin E2	cyclooxygenase-2	MESH:D015232	29527(Tax:10116)	Chemical	Gene	drugs|amod|START_ENTITY Up-regulation|nmod|drugs Up-regulation|nmod|expression expression|amod|END_ENTITY	Up-regulation of cyclooxygenase-2 expression in cultured microglia by prostaglandin_E2 , cyclic_AMP and non-steroidal anti-inflammatory drugs .
8273584	0	prostaglandin_E2	59,75	cytosolic_PLA2	27,41	prostaglandin E2	cytosolic PLA2	MESH:D015232	5321	Chemical	Gene	induces|nmod|START_ENTITY induces|dobj|END_ENTITY	Interleukin-1_beta induces cytosolic_PLA2 in parallel with prostaglandin_E2 in rheumatoid synovial fibroblasts .
11099107	0	prostaglandin_E2	79,95	endothelin-1	14,26	prostaglandin E2	endothelin-1	MESH:D015232	1906	Chemical	Gene	radiations|amod|START_ENTITY radiations|amod|END_ENTITY	Modulation of endothelin-1 in normal human keratinocytes by UVA1/B radiations , prostaglandin_E2 and peptidase inhibitors .
1397025	0	prostaglandin_E2	21,37	endothelin-1	88,100	prostaglandin E2	endothelin-1	MESH:D015232	1906	Chemical	Gene	production|amod|START_ENTITY production|dep|modulation modulation|nmod|response response|nmod|END_ENTITY	Endothelin-1-induced prostaglandin_E2 production : modulation of contractile response to endothelin-1 in porcine coronary artery .
9687319	0	prostaglandin_E2	35,51	endothelin-1	57,69	prostaglandin E2	endothelin-1	MESH:D015232	281137(Tax:9913)	Chemical	Gene	hormones|appos|START_ENTITY release|nmod|hormones release|acl:relcl|END_ENTITY	Local release of steroid hormones , prostaglandin_E2 , and endothelin-1 from bovine mature follicles In vitro : effects of luteinizing hormone , endothelin-1 , and cytokines .
16818638	0	prostaglandin_E2	89,105	epidermal_growth_factor	45,68	prostaglandin E2	epidermal growth factor	MESH:D015232	1950	Chemical	Gene	START_ENTITY|nsubj|Repression Repression|nmod|prostaglandin_dehydrogenase prostaglandin_dehydrogenase|nmod|increases increases|compound|END_ENTITY	Repression of prostaglandin_dehydrogenase by epidermal_growth_factor and snail increases prostaglandin_E2 and promotes cancer progression .
1805201	0	prostaglandin_E2	28,44	epidermal_growth_factor	59,82	prostaglandin E2	epidermal growth factor	MESH:D015232	1950	Chemical	Gene	production|amod|START_ENTITY laeve|dobj|production laeve|nmod|END_ENTITY	Regulation of chorion laeve prostaglandin_E2 production by epidermal_growth_factor , protein kinase C activation and calcium .
1813662	0	prostaglandin_E2	27,43	epidermal_growth_factor	55,78	prostaglandin E2	epidermal growth factor	MESH:D015232	13645(Tax:10090)	Chemical	Gene	stimulation|nmod|START_ENTITY release|nsubj|stimulation release|nmod|END_ENTITY	Synergistic stimulation of prostaglandin_E2 release by epidermal_growth_factor and a tumor promoter anthralin from primary cultures of mouse epidermal cells .
2146343	0	prostaglandin_E2	45,61	epidermal_growth_factor	12,35	prostaglandin E2	epidermal growth factor	MESH:D015232	1950	Chemical	Gene	synthesis|amod|START_ENTITY END_ENTITY|nmod|synthesis	-LSB- Effects of epidermal_growth_factor -LRB- EGF -RRB- on prostaglandin_E2 synthesis by cultured human endometrial cells -RSB- .
2830489	0	prostaglandin_E2	71,87	epidermal_growth_factor	110,133	prostaglandin E2	epidermal growth factor	MESH:D015232	403657(Tax:9615)	Chemical	Gene	line|nmod|START_ENTITY line|nmod|END_ENTITY	Induction of glucagon sensitivity in a transformed kidney cell line by prostaglandin_E2 and its inhibition by epidermal_growth_factor .
2995220	0	prostaglandin_E2	49,65	epidermal_growth_factor	22,45	prostaglandin E2	epidermal growth factor	MESH:D015232	13645(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY effect|nmod|production effect|nmod|END_ENTITY	Stimulatory effect of epidermal_growth_factor on prostaglandin_E2 production in mouse fibrosarcoma cell line -LRB- HSDM1 C1 -RRB- .
3096986	0	prostaglandin_E2	15,31	epidermal_growth_factor	94,117	prostaglandin E2	epidermal growth factor	MESH:D015232	13645(Tax:10090)	Chemical	Gene	synthesis|amod|START_ENTITY Stimulation|nmod|synthesis Stimulation|nmod|END_ENTITY	Stimulation of prostaglandin_E2 synthesis in cloned osteoblastic cells of mouse -LRB- MC3T3-E1 -RRB- by epidermal_growth_factor .
3139271	0	prostaglandin_E2	54,70	epidermal_growth_factor	14,37	prostaglandin E2	epidermal growth factor	MESH:D015232	1950	Chemical	Gene	output|amod|START_ENTITY action|nmod|output action|nmod|END_ENTITY	The action of epidermal_growth_factor on human amnion prostaglandin_E2 output .
6091385	0	prostaglandin_E2	105,121	epidermal_growth_factor	23,46	prostaglandin E2	epidermal growth factor	MESH:D015232	1950	Chemical	Gene	receptors|nmod|START_ENTITY receptors|nmod|END_ENTITY	Specific receptors for epidermal_growth_factor in human bone_tumour cells and its effect on synthesis of prostaglandin_E2 by cultured osteosarcoma cell line .
7648967	0	prostaglandin_E2	55,71	epidermal_growth_factor	83,106	prostaglandin E2	epidermal growth factor	MESH:D015232	100714471	Chemical	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	Induction of cyclooxygenase protein and stimulation of prostaglandin_E2 release by epidermal_growth_factor in cultured guinea_pig gastric mucous cells .
7829602	0	prostaglandin_E2	192,208	epidermal_growth_factor	45,68	prostaglandin E2	epidermal growth factor	MESH:D015232	1950	Chemical	Gene	synthesis|amod|START_ENTITY TGF_alpha|nmod|synthesis role|nmod|TGF_alpha Expression|dep|role Expression|nmod|acid acid|nmod|END_ENTITY	Expression of messenger ribonucleic acid for epidermal_growth_factor -LRB- EGF -RRB- , transforming_growth_factor-alpha -LRB- TGF_alpha -RRB- , and EGF_receptor in human amnion cells : possible role of TGF_alpha in prostaglandin_E2 synthesis and cell proliferation .
9247974	0	prostaglandin_E2	15,31	epidermal_growth_factor	46,69	prostaglandin E2	epidermal growth factor	MESH:D015232	1950	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Enhancement of prostaglandin_E2 production by epidermal_growth_factor requires the coordinate activation of cytosolic phospholipase_A2 and cyclooxygenase_2 in human squamous_carcinoma A431 cells .
15855163	0	prostaglandin_E2	25,41	epidermal_growth_factor_receptor	149,181	prostaglandin E2	epidermal growth factor receptor	MESH:D015232	1956	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|nmod|activation activation|nmod|END_ENTITY	Cyclooxygenase-2-derived prostaglandin_E2 promotes human cholangiocarcinoma cell growth and invasion through EP1 receptor-mediated activation of the epidermal_growth_factor_receptor and Akt .
6434592	0	prostaglandin_E2	19,35	erythropoietin	39,53	prostaglandin E2	erythropoietin	MESH:D015232	2056	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|production production|compound|END_ENTITY	Role of endogenous prostaglandin_E2 in erythropoietin production and dome formation by human renal_carcinoma cells in culture .
16905765	0	prostaglandin_E2	19,35	fibroblast_growth_factor_2	48,74	prostaglandin E2	fibroblast growth factor 2	MESH:D015232	2247	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Seminal plasma and prostaglandin_E2 up-regulate fibroblast_growth_factor_2 expression in endometrial_adenocarcinoma cells via E-series_prostanoid-2 receptor-mediated transactivation of the epidermal_growth_factor_receptor and extracellular_signal-regulated_kinase pathway .
2578327	0	prostaglandin_E2	10,26	gamma-interferon	34,50	prostaglandin E2	gamma-interferon	MESH:D015232	15978(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|induction induction|amod|END_ENTITY	Effect of prostaglandin_E2 on the gamma-interferon induction of antigen-presenting ability in P388D1 cells and on IL-2 production by T-cell hybridomas .
7521167	0	prostaglandin_E2	42,58	gp_120	12,18	prostaglandin E2	gp 120	MESH:D015232	3700	Chemical	Gene	release|amod|START_ENTITY release|amod|END_ENTITY	HIV coating gp_120 glycoprotein-dependent prostaglandin_E2 release by human cultured astrocytoma cells is regulated by nitric_oxide formation .
1397474	0	prostaglandin_E2	8,24	growth_hormone	82,96	prostaglandin E2	growth hormone	MESH:D015232	2688	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|action action|nmod|END_ENTITY	Role of prostaglandin_E2 -LRB- PGE2 -RRB- in the growth_hormone_releasing_hormone action on growth_hormone , insulin and C-peptide in normal men .
1397474	0	prostaglandin_E2	8,24	growth_hormone_releasing_hormone	39,71	prostaglandin E2	growth hormone releasing hormone	MESH:D015232	2691	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|action action|amod|END_ENTITY	Role of prostaglandin_E2 -LRB- PGE2 -RRB- in the growth_hormone_releasing_hormone action on growth_hormone , insulin and C-peptide in normal men .
9034831	2	prostaglandin_E2	781,797	iNOS	925,929	prostaglandin E2	iNOS	MESH:D015232	24599(Tax:10116)	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|compound|END_ENTITY	In this study we show that exogenous prostaglandin_E2 -LRB- PGE2 -RRB- , which is known to increase cyclic_adenosine_monophosphate -LRB- cAMP -RRB- levels in microglial cells , downregulates LPS-induced iNOS expression in a dose-dependent manner .
8702983	0	prostaglandin_E2	129,145	insulin-like_growth_factor-I	92,120	prostaglandin E2	insulin-like growth factor-I	MESH:D015232	24482(Tax:10116)	Chemical	Gene	controls|nmod|START_ENTITY controls|dobj|activation activation|nmod|gene gene|amod|END_ENTITY	Identification of the cAMP response element that controls transcriptional activation of the insulin-like_growth_factor-I gene by prostaglandin_E2 in osteoblasts .
1907761	0	prostaglandin_E2	8,24	interferon-gamma	38,54	prostaglandin E2	interferon-gamma	MESH:D015232	3458	Chemical	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Role of prostaglandin_E2 on defective interferon-gamma production during type B acute_viral_hepatitis .
3921560	0	prostaglandin_E2	13,29	interferon-gamma	50,66	prostaglandin E2	interferon-gamma	MESH:D015232	3458	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|production production|amod|END_ENTITY	Influence of prostaglandin_E2 and indomethacin on interferon-gamma production by cultured peripheral blood leukocytes of multiple_sclerosis patients and healthy donors .
12445196	0	prostaglandin_E2	44,60	interferon-induced_protein_of_10_kDa	88,124	prostaglandin E2	interferon-induced protein of 10 kDa	MESH:D015232	3627	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|nmod|END_ENTITY	Cyclooxygenase-2 inhibitor enhances whereas prostaglandin_E2 inhibits the production of interferon-induced_protein_of_10_kDa in epidermoid_carcinoma A431 .
1714774	0	prostaglandin_E2	44,60	interleukin-1	12,25	prostaglandin E2	interleukin-1	MESH:D015232	3552	Chemical	Gene	production|amod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Recombinant interleukin-1 -LRB- IL-1 -RRB- stimulates prostaglandin_E2 production by osteoblastic cells : role of calcium , calmodulin , and cAMP .
3019358	0	prostaglandin_E2	93,109	interleukin-1	14,27	prostaglandin E2	interleukin-1	MESH:D015232	3552	Chemical	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|induction induction|amod|END_ENTITY	Evidence that interleukin-1 induction of synovial cell plasminogen activator is mediated via prostaglandin_E2 and cAMP .
3135104	0	prostaglandin_E2	37,53	interleukin-1	12,25	prostaglandin E2	interleukin-1	MESH:D015232	111343(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY stimulates|dep|production stimulates|amod|END_ENTITY	Recombinant interleukin-1 stimulates prostaglandin_E2 production by osteoblastic cells : synergy with parathyroid_hormone .
3492161	0	prostaglandin_E2	87,103	interleukin-1	36,49	prostaglandin E2	interleukin-1	MESH:D015232	3552	Chemical	Gene	secretion|nmod|START_ENTITY activity|nmod|secretion activity|nsubj|_ _|amod|END_ENTITY	Human alveolar macrophages suppress interleukin-1 _ -LRB- IL-1 -RRB- activity via the secretion of prostaglandin_E2 .
7525383	0	prostaglandin_E2	108,124	interleukin-1	168,181	prostaglandin E2	interleukin-1	MESH:D015232	3552	Chemical	Gene	fibroblasts|nmod|START_ENTITY fibroblasts|parataxis|kinase kinase|dobj|A A|nmod|END_ENTITY	Transcriptional regulation of plasminogen_activator_inhibitor-1 expression in human synovial fibroblasts by prostaglandin_E2 : mediation by protein kinase A and role of interleukin-1 .
8140119	0	prostaglandin_E2	125,141	interleukin-1	73,86	prostaglandin E2	interleukin-1	MESH:D015232	3552	Chemical	Gene	production|amod|START_ENTITY production|amod|END_ENTITY	Epidermal_growth_factor and transforming_growth_factor-alpha enhance the interleukin-1 - and tumor_necrosis_factor-stimulated prostaglandin_E2 production and the interleukin-1 specific binding on amnion cells .
8225402	0	prostaglandin_E2	72,88	interleukin-1	18,31	prostaglandin E2	interleukin-1	MESH:D015232	3552	Chemical	Gene	generation|amod|START_ENTITY inhibits|dobj|generation inhibits|nsubj|antagonist antagonist|amod|END_ENTITY	Human recombinant interleukin-1 receptor antagonist -LRB- hrIL-1RA -RRB- inhibits prostaglandin_E2 -LRB- PGE2 -RRB- generation but not alkaline phosphatase activity in in vivo chronic granulomatous tissue induced by KMnO4 .
15596223	0	prostaglandin_E2	126,142	interleukin-10	64,78	prostaglandin E2	interleukin-10	MESH:D015232	3586	Chemical	Gene	production|nmod|START_ENTITY END_ENTITY|nmod|production	The effect of the anti-inflammatory cytokines interleukin-4 and interleukin-10 on lipopolysaccharide-stimulated production of prostaglandin_E2 by cultured human decidual cells .
2651547	0	prostaglandin_E2	40,56	interleukin-1_alpha	98,117	prostaglandin E2	interleukin-1 alpha	MESH:D015232	16175(Tax:10090)	Chemical	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	Regulation of monokine gene expression : prostaglandin_E2 suppresses tumor necrosis factor but not interleukin-1_alpha or beta-mRNA and cell-associated bioactivity .
8079657	0	prostaglandin_E2	15,31	interleukin-1_alpha	46,65	prostaglandin E2	interleukin-1 alpha	MESH:D015232	16175(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY Stimulation|nmod|production Stimulation|nmod|END_ENTITY	Stimulation of prostaglandin_E2 production by interleukin-1_alpha and transforming_growth_factor_alpha in osteoblastic MC3T3-E1 cells .
1442930	0	prostaglandin_E2	122,138	interleukin-1_and_tumor_necrosis_factor	67,106	prostaglandin E2	interleukin-1 and tumor necrosis factor	MESH:D015232	3552;7124	Chemical	Gene	production|amod|START_ENTITY production|amod|END_ENTITY	Transforming_growth_factor-beta opposes the stimulatory effects of interleukin-1_and_tumor_necrosis_factor on amnion cell prostaglandin_E2 production : implication for preterm_labor .
8195358	0	prostaglandin_E2	52,68	interleukin-1_beta	17,35	prostaglandin E2	interleukin-1 beta	MESH:D015232	3553	Chemical	Gene	correlates|nmod|START_ENTITY correlates|amod|END_ENTITY	Concentration of interleukin-1_beta correlates with prostaglandin_E2 and F2 alpha in human pre-ovulatory follicular fluid .
10800959	0	prostaglandin_E2	84,100	interleukin-1beta	164,181	prostaglandin E2	interleukin-1beta	MESH:D015232	24494(Tax:10116)	Chemical	Gene	action|nmod|START_ENTITY mediating|dobj|action neurons|acl|mediating analysis|nmod|neurons analysis|acl|circulating circulating|xcomp|END_ENTITY	A functional analysis of EP4 receptor-expressing neurons in mediating the action of prostaglandin_E2 within specific nuclei of the brain in response to circulating interleukin-1beta .
11847219	0	prostaglandin_E2	17,33	interleukin-1beta	47,64	prostaglandin E2	interleukin-1beta	MESH:D015232	3553	Chemical	Gene	synthesis|amod|START_ENTITY synthesis|nmod|END_ENTITY	Up-regulation of prostaglandin_E2 synthesis by interleukin-1beta in human orbital fibroblasts involves coordinate induction of prostaglandin-endoperoxide_H synthase-2 and glutathione-dependent prostaglandin_E2 synthase expression .
16210363	0	prostaglandin_E2	83,99	interleukin-1beta	128,145	prostaglandin E2	interleukin-1beta	MESH:D015232	3553	Chemical	Gene	induction|nmod|START_ENTITY influence|nmod|induction cytokines|dobj|influence cytokines|nmod|END_ENTITY	T helper type 1 and type 2 cytokines exert divergent influence on the induction of prostaglandin_E2 and hyaluronan synthesis by interleukin-1beta in orbital fibroblasts : implications for the pathogenesis of thyroid-associated_ophthalmopathy .
8751285	0	prostaglandin_E2	35,51	interleukin-1beta	121,138	prostaglandin E2	interleukin-1beta	MESH:D015232	24494(Tax:10116)	Chemical	Gene	circulating|dobj|START_ENTITY circulating|nmod|administration administration|nmod|END_ENTITY	A study on the role of circulating prostaglandin_E2 in the adrenocorticotropin response to intravenous administration of interleukin-1beta in the rat .
8782659	0	prostaglandin_E2	179,195	interleukin-1beta	105,122	prostaglandin E2	interleukin-1beta	MESH:D015232	3553	Chemical	Gene	role|nmod|START_ENTITY dissociation|nmod|role Regulation|dep|dissociation Regulation|nmod|cells cells|nmod|END_ENTITY	Regulation of arachidonic_acid metabolism , aromatase activity and growth in human breast_cancer cells by interleukin-1beta and phorbol_ester : dissociation of a mediatory role for prostaglandin_E2 in the autocrine control of cell function .
9141614	0	prostaglandin_E2	28,44	interleukin-1beta	109,126	prostaglandin E2	interleukin-1beta	MESH:D015232	3553	Chemical	Gene	synthesis|amod|START_ENTITY synthesis|dep|interactions interactions|nmod|END_ENTITY	Thrombin receptor-dependent prostaglandin_E2 synthesis in hamster fibroblasts : synergistic interactions with interleukin-1beta .
9244174	0	prostaglandin_E2	15,31	interleukin-1beta	45,62	prostaglandin E2	interleukin-1beta	MESH:D015232	3553	Chemical	Gene	synthesis|amod|START_ENTITY synthesis|nmod|END_ENTITY	Stimulation of prostaglandin_E2 synthesis by interleukin-1beta is amplified by interferons but inhibited by interleukin-4 in human amnion-derived WISH cells .
9416852	0	prostaglandin_E2	85,101	interleukin-1beta	201,218	prostaglandin E2	interleukin-1beta	MESH:D015232	3553	Chemical	Gene	proteoglycan|nummod|START_ENTITY production|nmod|proteoglycan osteogenic_protein_1|nmod|production Effects|nmod|osteogenic_protein_1 cultured|nsubj|Effects cultured|nmod|presence presence|nmod|END_ENTITY	Effects of recombinant human osteogenic_protein_1 on the production of proteoglycan , prostaglandin_E2 , and interleukin-1_receptor_antagonist by human articular chondrocytes cultured in the presence of interleukin-1beta .
9751081	0	prostaglandin_E2	42,58	interleukin-1beta	13,30	prostaglandin E2	interleukin-1beta	MESH:D015232	3553	Chemical	Gene	formation|amod|START_ENTITY Induction|nmod|formation Induction|nmod|peptide peptide|amod|END_ENTITY	Induction by interleukin-1beta peptide of prostaglandin_E2 formation via enhanced prostaglandin_H synthase-2 expression in 3T6 fibroblasts .
10090941	0	prostaglandin_E2	58,74	interleukin-2	144,157	prostaglandin E2	interleukin-2	MESH:D015232	3558	Chemical	Gene	agents|amod|START_ENTITY agents|dep|impact impact|nmod|receptor receptor|compound|END_ENTITY	Downregulation of JAK3 protein levels in T lymphocytes by prostaglandin_E2 and other cyclic_adenosine_monophosphate-elevating agents : impact on interleukin-2 receptor signaling pathway .
2175768	0	prostaglandin_E2	9,25	interleukin-2	77,90	prostaglandin E2	interleukin-2	MESH:D015232	3558	Chemical	Gene	production|amod|START_ENTITY vitro|dobj|production vitro|nmod|activation activation|compound|END_ENTITY	In vitro prostaglandin_E2 production by glioblastoma cells and its effect on interleukin-2 activation of oncolytic lymphocytes .
3485703	0	prostaglandin_E2	116,132	interleukin-2	187,200	prostaglandin E2	interleukin-2	MESH:D015232	3558	Chemical	Gene	patients|nmod|START_ENTITY lymphocytes|nmod|patients production|nmod|lymphocytes inhibition|nmod|production enhancement|nmod|inhibition enhancement|nmod|END_ENTITY	In vitro inhibition of interleukin-2 production by peripheral blood lymphocytes from stage_III_melanoma patients by prostaglandin_E2 : enhancement of lymphocyte proliferation by exogenous interleukin-2 plus indomethacin .
3485703	0	prostaglandin_E2	116,132	interleukin-2	23,36	prostaglandin E2	interleukin-2	MESH:D015232	3558	Chemical	Gene	patients|nmod|START_ENTITY lymphocytes|nmod|patients production|nmod|lymphocytes production|compound|END_ENTITY	In vitro inhibition of interleukin-2 production by peripheral blood lymphocytes from stage_III_melanoma patients by prostaglandin_E2 : enhancement of lymphocyte proliferation by exogenous interleukin-2 plus indomethacin .
3498487	0	prostaglandin_E2	15,31	interleukin-2	96,109	prostaglandin E2	interleukin-2	MESH:D015232	3558	Chemical	Gene	production|amod|START_ENTITY Stimulation|nmod|production Stimulation|nmod|END_ENTITY	Stimulation of prostaglandin_E2 and thromboxane_B2 production by human monocytes in response to interleukin-2 .
3873352	0	prostaglandin_E2	130,146	interleukin-2	92,105	prostaglandin E2	interleukin-2	MESH:D015232	3558	Chemical	Gene	suppression|amod|START_ENTITY acquired|nmod|suppression acquired|nsubj|activity activity|nmod|cells cells|acl|propagated propagated|nmod|presence presence|nmod|END_ENTITY	Natural killer-like activity in human cultured lymphoid cells propagated in the presence of interleukin-2 : acquired resistance to prostaglandin_E2 - or dexamethasone-mediated suppression .
8210948	0	prostaglandin_E2	65,81	interleukin-2	99,112	prostaglandin E2	interleukin-2	MESH:D015232	16183(Tax:10090)	Chemical	Gene	lymphokine-activated|nmod|START_ENTITY lymphokine-activated|nmod|phase phase|nmod|induction induction|compound|END_ENTITY	Responsiveness of murine lymphokine-activated killer activity to prostaglandin_E2 at late phase of interleukin-2 induction .
10211885	0	prostaglandin_E2	50,66	interleukin-4	112,125	prostaglandin E2	interleukin-4	MESH:D015232	3565	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Inhibition of tumor_necrosis_factor_alpha-induced prostaglandin_E2 production by the antiinflammatory cytokines interleukin-4 , interleukin-10 , and interleukin-13 in osteoarthritic synovial fibroblasts : distinct targeting in the signaling pathways .
11779582	0	prostaglandin_E2	17,33	interleukin-6	103,116	prostaglandin E2	interleukin-6	MESH:D015232	24498(Tax:10116)	Chemical	Gene	factor|amod|START_ENTITY Participation|nmod|factor Participation|nmod|END_ENTITY	Participation of prostaglandin_E2 and platelet-activating factor in thapsigargin-induced production of interleukin-6 .
17825413	0	prostaglandin_E2	190,206	interleukin-6	136,149	prostaglandin E2	interleukin-6	MESH:D015232	395337(Tax:9031)	Chemical	Gene	production|nmod|START_ENTITY leading|nmod|production leading|nmod|expression expression|acl|END_ENTITY	Thrombocytes respond to lipopolysaccharide through Toll-like_receptor-4 , and MAP kinase and NF-kappaB pathways leading to expression of interleukin-6 and cyclooxygenase-2 with production of prostaglandin_E2 .
19022895	0	prostaglandin_E2	91,107	interleukin-6	12,25	prostaglandin E2	interleukin-6	MESH:D015232	16193(Tax:10090)	Chemical	Gene	independent|nmod|START_ENTITY independent|amod|END_ENTITY	The role of interleukin-6 in lipopolysaccharide-induced fever by mechanisms independent of prostaglandin_E2 .
21371033	0	prostaglandin_E2	8,24	interleukin-6	75,88	prostaglandin E2	interleukin-6	MESH:D015232	24498(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY cytokine|nsubj|Role cytokine|xcomp|END_ENTITY	Role of prostaglandin_E2 in the synthesis of the pro-inflammatory cytokine interleukin-6 in primary sensory neurons : an in vivo and in vitro study .
25476497	0	prostaglandin_E2	119,135	interleukin-6	28,41	prostaglandin E2	interleukin-6	MESH:D015232	3569	Chemical	Gene	production|amod|START_ENTITY expression|nmod|production promotes|dobj|expression promotes|nsubj|END_ENTITY	Obesity-associated systemic interleukin-6 promotes pre-adipocyte aromatase expression via increased_breast_cancer cell prostaglandin_E2 production .
25916550	0	prostaglandin_E2	79,95	interleukin-6	96,109	prostaglandin E2	interleukin-6	MESH:D015232	3569	Chemical	Gene	/|amod|START_ENTITY signaling|nsubj|/ signaling|dep|END_ENTITY	Epigenetic silencing of microRNA-149 in cancer-associated fibroblasts mediates prostaglandin_E2 / interleukin-6 signaling in the tumor microenvironment .
25916550	0	prostaglandin_E2	79,95	interleukin-6	96,109	prostaglandin E2	interleukin-6	MESH:D015232	3569	Chemical	Gene	/|amod|START_ENTITY signaling|nsubj|/ signaling|dep|END_ENTITY	Epigenetic silencing of microRNA-149 in cancer-associated fibroblasts mediates prostaglandin_E2 / interleukin-6 signaling in the tumor microenvironment .
8315354	0	prostaglandin_E2	153,169	interleukin-6	171,184	prostaglandin E2	interleukin-6	MESH:D015232	3569	Chemical	Gene	not|nmod|START_ENTITY or_tumor_necrosis_factor-alpha|dep|not or_tumor_necrosis_factor-alpha|amod|END_ENTITY	Effects of macrophage-colony_stimulating_factor on human monocytes : induction of expression of urokinase-type_plasminogen_activator , but not of secreted prostaglandin_E2 , interleukin-6 , interleukin-1 , _ or_tumor_necrosis_factor-alpha .
9661073	0	prostaglandin_E2	42,58	interleukin-6	14,27	prostaglandin E2	interleukin-6	MESH:D015232	24498(Tax:10116)	Chemical	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Regulation of interleukin-6 production by prostaglandin_E2 in fetal rat osteoblasts : role of protein_kinase_A signaling pathway .
9732406	0	prostaglandin_E2	26,42	interleukin-6	57,70	prostaglandin E2	interleukin-6	MESH:D015232	3569	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|generation generation|amod|END_ENTITY	EP4/EP2 receptor-specific prostaglandin_E2 regulation of interleukin-6 generation by human HSB .2 early T cells .
2330842	0	prostaglandin_E2	19,35	interleukin_1	39,52	prostaglandin E2	interleukin 1	MESH:D015232	3552	Chemical	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Role of endogenous prostaglandin_E2 in interleukin_1 production by peripheral blood monocytes from patients with rheumatoid_arthritis .
2988854	0	prostaglandin_E2	205,221	interleukin_1	94,107	prostaglandin E2	interleukin 1	MESH:D015232	3552	Chemical	Gene	effects|nmod|START_ENTITY medium|dep|effects medium|acl|containing containing|dobj|mononuclear_cell_factor mononuclear_cell_factor|acl|homologous homologous|nmod|collagen collagen|amod|END_ENTITY	Mononuclear cell-conditioned medium containing mononuclear_cell_factor -LRB- MCF -RRB- , homologous with interleukin_1 , stimulates collagen and fibronectin synthesis by adherent rheumatoid synovial cells : effects of prostaglandin_E2 and indomethacin .
3871360	0	prostaglandin_E2	42,58	interleukin_2	14,27	prostaglandin E2	interleukin 2	MESH:D015232	16183(Tax:10090)	Chemical	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Inhibition of interleukin_2 production by prostaglandin_E2 is not absolute but depends on the strength of the stimulating signal .
8643498	0	prostaglandin_E2	37,53	interleukin_6	9,22	prostaglandin E2	interleukin 6	MESH:D015232	16193(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Elevated interleukin_6 is induced by prostaglandin_E2 in a murine model of inflammation : possible role of cyclooxygenase-2 .
8738072	0	prostaglandin_E2	105,121	kallikrein	56,66	prostaglandin E2	kallikrein	MESH:D015232	9622	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|compound|END_ENTITY	Effects of perindopril treatment on plasma and urine of kallikrein activity and the stable metabolite of prostaglandin_E2 in patients with essential hypertension .
6392920	0	prostaglandin_E2	15,31	luteinizing_hormone-releasing_hormone_and_luteinizing-hormone	96,157	prostaglandin E2	luteinizing hormone-releasing hormone and luteinizing-hormone	MESH:D015232	25194(Tax:10116)	Chemical	Gene	actions|nmod|START_ENTITY actions|nmod|secretion secretion|amod|END_ENTITY	The actions of prostaglandin_E2 , naloxone and testosterone on starvation-induced suppression of luteinizing_hormone-releasing_hormone_and_luteinizing-hormone secretion .
15953724	0	prostaglandin_E2	39,55	mPGES-1	66,73	prostaglandin E2	mPGES-1	MESH:D015232	64292(Tax:10090)	Chemical	Gene	synthase|amod|START_ENTITY synthase|dep|END_ENTITY	Inhibitors of the inducible microsomal prostaglandin_E2 synthase -LRB- mPGES-1 -RRB- derived from MK-886 .
14764723	0	prostaglandin_E2	45,61	osteoprotegerin	15,30	prostaglandin E2	osteoprotegerin	MESH:D015232	18383(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Suppression of osteoprotegerin expression by prostaglandin_E2 is crucially involved in lipopolysaccharide-induced osteoclast formation .
9642127	0	prostaglandin_E2	45,61	osteoprotegerin	14,29	prostaglandin E2	osteoprotegerin	MESH:D015232	4982	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|levels levels|amod|END_ENTITY	Regulation of osteoprotegerin mRNA levels by prostaglandin_E2 in human bone marrow_stroma cells .
24145719	0	prostaglandin_E2	11,27	p53	31,34	prostaglandin E2	p53	MESH:D015232	7157	Chemical	Gene	START_ENTITY|nmod|transcription transcription|compound|END_ENTITY	Effects of prostaglandin_E2 on p53 mRNA transcription and p53 mutagenesis during T-cell-independent human B-cell clonal expansion .
15964894	0	prostaglandin_E2	37,53	phospholipase_A2	78,94	prostaglandin E2	phospholipase A2	MESH:D015232	151056	Chemical	Gene	production|amod|START_ENTITY mutation|nmod|production Impact|nmod|mutation IIA|nsubj|Impact IIA|dobj|expression expression|amod|END_ENTITY	Impact of CFTR DeltaF508 mutation on prostaglandin_E2 production and type IIA phospholipase_A2 expression by pulmonary epithelial cells .
16203828	0	prostaglandin_E2	109,125	phospholipase_A2	54,70	prostaglandin E2	phospholipase A2	MESH:D015232	151056	Chemical	Gene	release|compound|START_ENTITY effects|nmod|release effects|nmod|inhibitors inhibitors|amod|END_ENTITY	Systemic and intrathecal effects of a novel series of phospholipase_A2 inhibitors on hyperalgesia and spinal prostaglandin_E2 release .
17459165	0	prostaglandin_E2	43,59	phospholipase_A2	9,25	prostaglandin E2	phospholipase A2	MESH:D015232	104974671	Chemical	Gene	production|amod|START_ENTITY regulate|dobj|production regulate|nsubj|enzymes enzymes|amod|END_ENTITY	Distinct phospholipase_A2 enzymes regulate prostaglandin_E2 and F2alpha production by bovine endometrial epithelial cells .
1761509	0	prostaglandin_E2	16,32	phospholipase_A2	57,73	prostaglandin E2	phospholipase A2	MESH:D015232	151056	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Augmentation of prostaglandin_E2 production by mammalian phospholipase_A2 added exogenously .
7957239	0	prostaglandin_E2	22,38	phospholipase_A2	113,129	prostaglandin E2	phospholipase A2	MESH:D015232	151056	Chemical	Gene	biosynthesis|amod|START_ENTITY involves|nsubj|biosynthesis involves|dobj|activation activation|nmod|END_ENTITY	Interleukin-1-induced prostaglandin_E2 biosynthesis in human synovial cells involves the activation of cytosolic phospholipase_A2 and cyclooxygenase-2 .
8832976	0	prostaglandin_E2	113,129	phospholipase_A2	48,64	prostaglandin E2	phospholipase A2	MESH:D015232	151056	Chemical	Gene	reduces|dobj|START_ENTITY reduces|nsubj|Suppression Suppression|nmod|END_ENTITY	Suppression of human synovial fibroblast 85 kDa phospholipase_A2 by antisense reduces interleukin-1_beta induced prostaglandin_E2 .
9038215	0	prostaglandin_E2	119,135	phospholipase_A2	24,40	prostaglandin E2	phospholipase A2	MESH:D015232	18784(Tax:10090)	Chemical	Gene	synthesis|amod|START_ENTITY essential|nmod|synthesis essential|nsubj|Activation Activation|nmod|END_ENTITY	Activation of cytosolic phospholipase_A2 by platelet-derived growth factor is essential for cyclooxygenase-2-dependent prostaglandin_E2 synthesis in mouse osteoblasts cultured with interleukin-1 .
9247974	0	prostaglandin_E2	15,31	phospholipase_A2	118,134	prostaglandin E2	phospholipase A2	MESH:D015232	151056	Chemical	Gene	production|amod|START_ENTITY Enhancement|nmod|production requires|nsubj|Enhancement requires|dobj|activation activation|nmod|END_ENTITY	Enhancement of prostaglandin_E2 production by epidermal_growth_factor requires the coordinate activation of cytosolic phospholipase_A2 and cyclooxygenase_2 in human squamous_carcinoma A431 cells .
11811551	0	prostaglandin_E2	149,165	receptor_activator_of_nuclear_factor_kappaB_ligand	80,130	prostaglandin E2	receptor activator of nuclear factor kappaB ligand	MESH:D015232	8600	Chemical	Gene	synthesis|amod|START_ENTITY up-regulation|nmod|synthesis up-regulation|amod|END_ENTITY	Periodontal ligament cells under mechanical stress induce osteoclastogenesis by receptor_activator_of_nuclear_factor_kappaB_ligand up-regulation via prostaglandin_E2 synthesis .
19062743	0	prostaglandin_E2	100,116	receptor_activator_of_nuclear_factor_kappaB_ligand	15,65	prostaglandin E2	receptor activator of nuclear factor kappaB ligand	MESH:D015232	117516(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	-LSB- Regulation of receptor_activator_of_nuclear_factor_kappaB_ligand and osteoprotegerin expression by prostaglandin_E2 in osteoblastic-like cells -RSB- .
3536150	0	prostaglandin_E2	50,66	renin	70,75	prostaglandin E2	renin	MESH:D015232	5972	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	Evidence for a direct renal stimulating effect of prostaglandin_E2 on renin release in patients with congestive_heart_failure .
6143602	0	prostaglandin_E2	151,167	renin	136,141	prostaglandin E2	renin	MESH:D015232	24715(Tax:10116)	Chemical	Gene	enalapril|amod|START_ENTITY enalapril|appos|END_ENTITY	Effect of enalapril -LRB- MK-421 -RRB- , an orally active angiotensin_I_converting_enzyme inhibitor , on blood pressure , active and inactive plasma renin , urinary prostaglandin_E2 , and kallikrein excretion in conscious rats .
6360871	1	prostaglandin_E2	47,63	renin	75,80	prostaglandin E2	renin	MESH:D015232	24715(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect on urinary prostaglandin_E2 and plasma renin in response to variations in sodium intake and in relation to blood pressure .
7031725	0	prostaglandin_E2	83,99	renin	43,48	prostaglandin E2	renin	MESH:D015232	5972	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Effect of antihypertensive drugs on plasma renin activity and urinary excretion of prostaglandin_E2 .
877383	0	prostaglandin_E2	32,48	renin	15,20	prostaglandin E2	renin	MESH:D015232	24715(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|Stimulation Stimulation|nmod|END_ENTITY	Stimulation of renin release by prostaglandin_E2 .
7687126	0	prostaglandin_E2	50,66	transforming_growth_factor-alpha	81,113	prostaglandin E2	transforming growth factor-alpha	MESH:D015232	24827(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Activation of phospholipase A2 and stimulation of prostaglandin_E2 production by transforming_growth_factor-alpha in rat thymic epithelial cells requires influx of calcium .
7829602	0	prostaglandin_E2	192,208	transforming_growth_factor-alpha	76,108	prostaglandin E2	transforming growth factor-alpha	MESH:D015232	7124	Chemical	Gene	synthesis|amod|START_ENTITY TGF_alpha|nmod|synthesis role|nmod|TGF_alpha Expression|dep|role Expression|nmod|acid acid|appos|END_ENTITY	Expression of messenger ribonucleic acid for epidermal_growth_factor -LRB- EGF -RRB- , transforming_growth_factor-alpha -LRB- TGF_alpha -RRB- , and EGF_receptor in human amnion cells : possible role of TGF_alpha in prostaglandin_E2 synthesis and cell proliferation .
3148653	0	prostaglandin_E2	97,113	tumor_necrosis_factor	15,36	prostaglandin E2	tumor necrosis factor	MESH:D015232	103694380	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|release release|nmod|END_ENTITY	The release of tumor_necrosis_factor from endotoxin-stimulated rat Kupffer cells is regulated by prostaglandin_E2 and dexamethasone .
16619186	0	prostaglandin_E2	15,31	tumor_necrosis_factor-alpha	105,132	prostaglandin E2	tumor necrosis factor-alpha	MESH:D015232	7124	Chemical	Gene	products|amod|START_ENTITY Suppression|nmod|products promotes|nsubj|Suppression promotes|dobj|overproduction overproduction|nmod|END_ENTITY	Suppression of prostaglandin_E2 by malaria parasite products and antipyretics promotes overproduction of tumor_necrosis_factor-alpha : association with the pathogenesis of childhood malarial_anemia .
1965895	0	prostaglandin_E2	75,91	tumor_necrosis_factor-alpha	15,42	prostaglandin E2	tumor necrosis factor-alpha	MESH:D015232	24835(Tax:10116)	Chemical	Gene	Enhancement|nmod|START_ENTITY Enhancement|nmod|expression expression|amod|END_ENTITY	Enhancement of tumor_necrosis_factor-alpha gene expression by low doses of prostaglandin_E2 and cyclic_GMP .
26724477	0	prostaglandin_E2	151,167	tumor_necrosis_factor_alpha	122,149	prostaglandin E2	tumor necrosis factor alpha	MESH:D015232	7124	Chemical	Gene	production|amod|START_ENTITY production|amod|END_ENTITY	Anti-inflammatory effects of the butanolic fraction of Byrsonima verbascifolia leaves : Mechanisms involving inhibition of tumor_necrosis_factor_alpha , prostaglandin_E2 production and migration of polymorphonuclear leucocyte in vivo experimentation .
7812678	0	prostaglandin_E2	94,110	tumor_necrosis_factor_alpha	41,68	prostaglandin E2	tumor necrosis factor alpha	MESH:D015232	24835(Tax:10116)	Chemical	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	Regulation of lipopolysaccharide-induced tumor_necrosis_factor_alpha production by endogenous prostaglandin_E2 in rat resident and thioglycollate-elicited macrophages .
8804726	0	prostaglandin_E2	55,71	tyrosine_hydroxylase	31,51	prostaglandin E2	tyrosine hydroxylase	MESH:D015232	25085(Tax:10116)	Chemical	Gene	enhancement|nmod|START_ENTITY enhancement|nmod|END_ENTITY	Transcriptional enhancement of tyrosine_hydroxylase by prostaglandin_E2 in SK-N-BE -LRB- 2 -RRB- _ C cells .
18949628	0	prostaglandin_E2	10,26	urokinase-type_plasminogen_activator	30,66	prostaglandin E2	urokinase-type plasminogen activator	MESH:D015232	5328	Chemical	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Effect of prostaglandin_E2 on urokinase-type_plasminogen_activator production by human lung fibroblasts .
8315354	0	prostaglandin_E2	153,169	urokinase-type_plasminogen_activator	95,131	prostaglandin E2	urokinase-type plasminogen activator	MESH:D015232	5328	Chemical	Gene	not|nmod|START_ENTITY or_tumor_necrosis_factor-alpha|dep|not or_tumor_necrosis_factor-alpha|amod|END_ENTITY	Effects of macrophage-colony_stimulating_factor on human monocytes : induction of expression of urokinase-type_plasminogen_activator , but not of secreted prostaglandin_E2 , interleukin-6 , interleukin-1 , _ or_tumor_necrosis_factor-alpha .
19210337	0	prostaglandin_E2	25,41	vascular_endothelial_growth_factor	57,91	prostaglandin E2	vascular endothelial growth factor	MESH:D015232	7422	Chemical	Gene	involved|nsubjpass|START_ENTITY involved|nmod|production production|compound|END_ENTITY	Cyclooxygenase-2-derived prostaglandin_E2 is involved in vascular_endothelial_growth_factor production in interleukin-1alpha-stimulated human periodontal ligament cells .
23656623	0	prostaglandin_E2	119,135	vascular_endothelial_growth_factor	62,96	prostaglandin E2	vascular endothelial growth factor	MESH:D015232	7422	Chemical	Gene	induced|nmod|START_ENTITY production|acl|induced production|compound|END_ENTITY	Phosphodiesterase-4 inhibition augments human lung fibroblast vascular_endothelial_growth_factor production induced by prostaglandin_E2 .
9261124	0	prostaglandin_E2_ethanolamide	13,42	cyclooxygenase-2	62,78	prostaglandin E2 ethanolamide	cyclooxygenase-2	MESH:C107684	5743	Chemical	Gene	Synthesis|nmod|START_ENTITY Synthesis|nmod|END_ENTITY	Synthesis of prostaglandin_E2_ethanolamide from anandamide by cyclooxygenase-2 .
4344730	0	prostaglandin_E_1	10,27	parathyroid_hormone	56,75	prostaglandin E 1	parathyroid hormone	MESH:D000527	5741	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of prostaglandin_E_1 on certain renal actions of parathyroid_hormone .
14979715	0	prostaglandin_F	27,42	AKR1C3	53,59	prostaglandin F	AKR1C3	null	8644	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Crystal structure of human prostaglandin_F synthase -LRB- AKR1C3 -RRB- .
2069577	0	prostaglandin_F2-alpha	63,85	Basic_fibroblast_growth_factor	0,30	prostaglandin F2-alpha	Basic fibroblast growth factor	MESH:D015237	54250(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Basic_fibroblast_growth_factor in rat corpus luteum stimulates prostaglandin_F2-alpha production .
1857721	0	prostaglandin_F2_alpha	24,46	Endothelin-1	0,12	prostaglandin F2 alpha	Endothelin-1	MESH:D015237	1906	Chemical	Gene	release|amod|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Endothelin-1 stimulates prostaglandin_F2_alpha release from human endometrium .
8464006	0	prostaglandin_F2_alpha	57,79	beta-endorphin	26,40	prostaglandin F2 alpha	beta-endorphin	MESH:D015237	281416(Tax:9913)	Chemical	Gene	Stimulation|nmod|START_ENTITY Stimulation|nmod|END_ENTITY	Stimulation of release of beta-endorphin and oxytocin by prostaglandin_F2_alpha in cattle at parturition .
22851578	0	prostaglandin_F2a	20,37	Akr1b7	54,60	prostaglandin F2a	Akr1b7	CHEBI:15553	11997(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|acl|lacking lacking|dobj|END_ENTITY	Depressed levels of prostaglandin_F2a in mice lacking Akr1b7 increase basal adiposity and predispose to diet-induced obesity .
12724323	0	prostaglandin_F2alpha	14,35	Cyr61	94,99	prostaglandin F2alpha	Cyr61	MESH:D015237	3491	Chemical	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|END_ENTITY	Comparison of prostaglandin_F2alpha , bimatoprost -LRB- prostamide -RRB- , and butaprost -LRB- EP2 agonist -RRB- on Cyr61 and connective_tissue_growth_factor gene expression .
15838293	0	prostaglandin_F2alpha	103,124	Endothelin-1	0,12	prostaglandin F2alpha	Endothelin-1	MESH:D015237	281137(Tax:9913)	Chemical	Gene	interaction|nmod|START_ENTITY END_ENTITY|dep|interaction	Endothelin-1 within the corpus luteum during spontaneous luteolysis in the cow : local interaction with prostaglandin_F2alpha and angiotensin II .
21513166	0	prostaglandin_F2alpha	38,59	PTGFR	70,75	prostaglandin F2alpha	PTGFR	MESH:D015237	397126(Tax:9823)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	-LSB- Genetic variation and association of prostaglandin_F2alpha receptor -LRB- PTGFR -RRB- gene with sow maternal behaviors in a White Duroc x Erhualian resource population -RSB- .
21270323	0	prostaglandin_F2alpha	49,70	Surfactant_protein-A	0,20	prostaglandin F2alpha	Surfactant protein-A	MESH:D015237	653509	Chemical	Gene	production|amod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Surfactant_protein-A -LRB- SP-A -RRB- selectively inhibits prostaglandin_F2alpha -LRB- PGF2alpha -RRB- production in term decidua : implications for the onset of labor .
10862006	0	prostaglandin_F2alpha	39,60	Tumor_necrosis_factor-alpha	0,27	prostaglandin F2alpha	Tumor necrosis factor-alpha	MESH:D015237	280943(Tax:9913)	Chemical	Gene	secretion|amod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha stimulates prostaglandin_F2alpha secretion by bovine luteal cells via activation of mitogen-activated protein kinase and phospholipase_A2 pathways .
15271885	0	prostaglandin_F2alpha	60,81	cyp19	35,40	prostaglandin F2alpha	cyp19	MESH:D015237	13075(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	In vivo and in vitro inhibition of cyp19 gene expression by prostaglandin_F2alpha in murine luteal cells : implication of GATA-4 .
10394087	0	prostaglandin_F2alpha	14,35	phospholipase_A2	84,100	prostaglandin F2alpha	phospholipase A2	MESH:D015237	151056	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Regulation of prostaglandin_F2alpha by the specific inhibition of secretory type II phospholipase_A2 : implications for the management of premature_labour .
13679315	0	prostaglandin_F2alpha	79,100	tumor_necrosis_factor-alpha	48,75	prostaglandin F2alpha	tumor necrosis factor-alpha	MESH:D015237	280943(Tax:9913)	Chemical	Gene	synthesis|amod|START_ENTITY END_ENTITY|nmod|synthesis	Interferon-tau blocks the stimulatory effect of tumor_necrosis_factor-alpha on prostaglandin_F2alpha synthesis by bovine endometrial stromal cells .
8140262	0	prostaglandin_G	60,75	COX-2	103,108	prostaglandin G	COX-2	null	26198(Tax:10116)	Chemical	Gene	START_ENTITY|xcomp|activity activity|appos|END_ENTITY	NS-398 , a new anti-inflammatory agent , selectively inhibits prostaglandin_G / H synthase/cyclooxygenase -LRB- COX-2 -RRB- activity in vitro .
8852946	0	prostaglandin_G	23,38	Interleukin-4	0,13	prostaglandin G	Interleukin-4	null	16189(Tax:10090)	Chemical	Gene	inhibits|xcomp|START_ENTITY inhibits|nsubj|END_ENTITY	Interleukin-4 inhibits prostaglandin_G / H synthase-2 and cytosolic_phospholipase_A2 induction in neonatal mouse parietal bone cultures .
9348193	0	prostaglandin_G	47,62	Transforming_growth_factor-beta1	0,32	prostaglandin G	Transforming growth factor-beta1	null	21803(Tax:10090)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Transforming_growth_factor-beta1 regulation of prostaglandin_G / H synthase-2 expression in osteoblastic MC3T3-E1 cells .
15657087	0	prostaglandin_H	33,48	IL-10	24,29	prostaglandin H	IL-10	null	16153(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Differential effects of IL-10 on prostaglandin_H synthase-2 expression and prostaglandin_E2 biosynthesis between spleen and bone marrow macrophages .
8562397	0	prostaglandin_H	34,49	PGHS-1	62,68	prostaglandin H	PGHS-1	null	5742	Chemical	Gene	deficiency|amod|START_ENTITY deficiency|appos|END_ENTITY	Bleeding_disorder due to platelet prostaglandin_H synthase-1 -LRB- PGHS-1 -RRB- deficiency .
7488650	1	prostaglandin_H	152,167	TXAS	212,216	prostaglandin H	TXAS	null	6916	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	We determined the expression of isoforms of prostaglandin_H synthase -LRB- PGHS -RRB- and thromboxane_A_synthase -LRB- TXAS -RRB- in a human megakaryocyte cell line -LRB- MEG-01 .
16475787	0	prostaglandin_H2	37,53	PGFS	111,115	prostaglandin H2	PGFS	MESH:D044262	8644	Chemical	Gene	synthase|amod|START_ENTITY formation|nmod|synthase formation|dep|structure structure|nmod|END_ENTITY	Prostaglandin_F2alpha formation from prostaglandin_H2 by prostaglandin_F synthase -LRB- PGFS -RRB- : crystal structure of PGFS containing bimatoprost .
16475787	0	prostaglandin_H2	37,53	PGFS	83,87	prostaglandin H2	PGFS	MESH:D044262	8644	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	Prostaglandin_F2alpha formation from prostaglandin_H2 by prostaglandin_F synthase -LRB- PGFS -RRB- : crystal structure of PGFS containing bimatoprost .
1731622	0	prostaglandin_I2	39,55	interleukin_6	22,35	prostaglandin I2	interleukin 6	MESH:D011464	280826(Tax:9913)	Chemical	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	Inhibitory effects of interleukin_6 on prostaglandin_I2 production in cultured bovine vascular endothelial cells .
24402297	0	prostaglandin_I2	10,26	macrophage_inflammatory_protein_1a	38,72	prostaglandin I2	macrophage inflammatory protein 1a	MESH:D011464	6348	Chemical	Gene	analogs|amod|START_ENTITY analogs|nmod|END_ENTITY	Effect of prostaglandin_I2 analogs on macrophage_inflammatory_protein_1a in human monocytes via I prostanoid receptor and cyclic_adenosine_monophosphate .
15523637	0	prostaglandin_J2	11,27	cyclooxygenase-2	37,53	prostaglandin J2	cyclooxygenase-2	MESH:C037112	5743	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Neurotoxic prostaglandin_J2 enhances cyclooxygenase-2 expression in neuronal cells through the p38MAPK pathway : a death wish ?
1549109	0	prostaglandin_PGA2	60,78	HSP70	13,18	prostaglandin PGA2	HSP70	null	3308	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Induction of HSP70 gene expression by the antiproliferative prostaglandin_PGA2 : a growth-dependent response mediated by activation of heat_shock transcription factor .
23814676	0	prostaglandin_e2	10,26	vascular_endothelial_growth_factor	30,64	prostaglandin e2	vascular endothelial growth factor	MESH:D015232	7422	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Effect of prostaglandin_e2 on vascular_endothelial_growth_factor production in nasal polyp fibroblasts .
2967770	0	prostaglandin_endoperoxide	19,45	CV-4151	78,85	prostaglandin endoperoxide	CV-4151	null	2549726(Tax:243365)	Chemical	Gene	START_ENTITY|dobj|activity activity|nmod|END_ENTITY	The thromboxane_A2 / prostaglandin_endoperoxide receptor antagonist activity of CV-4151 , a thromboxane_A2 synthetase inhibitor .
6896278	0	prostaglandin_endoperoxide	52,78	SIN-1	0,5	prostaglandin endoperoxide	SIN-1	null	79109	Chemical	Gene	inhibits|dep|START_ENTITY inhibits|nsubj|END_ENTITY	SIN-1 , the main metabolite of molsidomine , inhibits prostaglandin_endoperoxide analogue - and arachidonic_acid-induced platelet_aggregation as well as platelet thromboxane_A2 formation .
197569	0	prostaglandins	72,86	ACTH	15,19	prostaglandins	ACTH	MESH:D011453	5443	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Stimulation Stimulation|nmod|END_ENTITY	Stimulation of ACTH secretion by indomethacin and reversal by exogenous prostaglandins .
230143	0	prostaglandins	67,81	ACTH	14,18	prostaglandins	ACTH	MESH:D011453	5443	Chemical	Gene	metabolism|nmod|START_ENTITY effect|nmod|metabolism effect|nmod|END_ENTITY	The effect of ACTH and its fragments on the in vitro metabolism of prostaglandins .
7282958	0	prostaglandins	80,94	Bradykinin	0,10	prostaglandins	Bradykinin	MESH:D011453	478666(Tax:9615)	Chemical	Gene	relation|nmod|START_ENTITY effects|dep|relation effects|compound|END_ENTITY	Bradykinin effects on adrenergic transmission in the canine kidney : relation to prostaglandins .
11509575	0	prostaglandins	75,89	COX-2	49,54	prostaglandins	COX-2	MESH:D011453	4513	Chemical	Gene	roles|nmod|START_ENTITY regulation|dep|roles regulation|nmod|NF-kappaB NF-kappaB|nmod|END_ENTITY	Positive and negative regulation of NF-kappaB by COX-2 : roles of different prostaglandins .
21277633	0	prostaglandins	24,38	COX-2	100,105	prostaglandins	COX-2	MESH:D011453	4513	Chemical	Gene	START_ENTITY|advcl|repressing repressing|dobj|expression expression|amod|END_ENTITY	IL-4 and IL-13 suppress prostaglandins production in human follicular dendritic cells by repressing COX-2 and mPGES-1 expression through JAK1 and STAT6 .
21417030	0	prostaglandins	21,35	COX-2	1,6	prostaglandins	COX-2	MESH:D011453	5743	Chemical	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	-LSB- COX-2 regulation of prostaglandins in synaptic signaling -RSB- .
22109885	0	prostaglandins	215,229	COX-2	37,42	prostaglandins	COX-2	MESH:D011453	4513	Chemical	Gene	production|nmod|START_ENTITY enzyme|nmod|production mannosidase|ccomp|enzyme mannosidase|nsubj|degradation degradation|nmod|END_ENTITY	Ubiquitin-proteasomal degradation of COX-2 in TGF-b stimulated human endometrial cells is mediated through endoplasmic reticulum mannosidase I. Cyclooxygenase _ -LRB- COX -RRB- -2 is a key regulatory enzyme in the production of prostaglandins -LRB- PG -RRB- during various physiological processes .
1775636	0	prostaglandins	8,22	CRH	115,118	prostaglandins	CRH	MESH:D011453	1392	Chemical	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of prostaglandins and leukotrienes in the synergistic effect of oxytocin and corticotropin-releasing_hormone -LRB- CRH -RRB- on the contraction force in human gestational myometrium .
7280117	0	prostaglandins	11,25	E1_and_E2	26,35	prostaglandins	E1 and E2	MESH:D011453	6080;6044	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of prostaglandins E1_and_E2 on the in vitro production of immunoglobulin by human peripheral blood lymphocytes .
9785380	0	prostaglandins	14,28	E1_and_E2	29,38	prostaglandins	E1 and E2	MESH:D011453	6080;6044	Chemical	Gene	Production|nmod|START_ENTITY END_ENTITY|nsubj|Production	Production of prostaglandins E1_and_E2 by adult human red blood cells .
14643177	0	prostaglandins	38,52	Epidermal_growth_factor	0,23	prostaglandins	Epidermal growth factor	MESH:D011453	25313(Tax:10116)	Chemical	Gene	modulation|nmod|START_ENTITY modulation|amod|END_ENTITY	Epidermal_growth_factor modulation of prostaglandins and nitrite biosynthesis in rat fetal membranes .
7308621	0	prostaglandins	28,42	Fc_receptor	46,57	prostaglandins	Fc receptor	MESH:D011453	109615(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Lack of effect of exogenous prostaglandins on Fc_receptor expression of mouse splenocytes .
16339488	8	prostaglandins	1199,1213	HAS2	1132,1136	prostaglandins	HAS2	MESH:D011453	3037	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	HAS2 , HAS1 , and HA synthesis were strongly induced by vasodilatory prostaglandins via Gs-coupled prostaglandin receptors .
2477997	0	prostaglandins	11,25	IL-1	54,58	prostaglandins	IL-1	MESH:D011453	3552	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|production production|compound|END_ENTITY	Effects of prostaglandins and cAMP levels on monocyte IL-1 production .
8953469	0	prostaglandins	131,145	IL-1_beta	26,35	prostaglandins	IL-1 beta	MESH:D011453	24494(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY effect|dep|role effect|nmod|END_ENTITY	Changing effect of i.c.v. IL-1_beta on vasopressin release in anaesthetized , female rats at different stages of lactation : role of prostaglandins and noradrenaline .
7720090	0	prostaglandins	56,70	IL-4	14,18	prostaglandins	IL-4	MESH:D011453	16189(Tax:10090)	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|production production|compound|END_ENTITY	Modulation of IL-4 production in murine spleen cells by prostaglandins .
4755182	0	prostaglandins	14,28	Itch	0,4	prostaglandins	Itch	MESH:D011453	83737	Chemical	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Itch : role of prostaglandins .
2854153	0	prostaglandins	11,25	LDL_receptor	29,41	prostaglandins	LDL receptor	MESH:D011453	3949	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Effects of prostaglandins on LDL_receptor activity and cholesterol synthesis in freshly isolated human mononuclear leukocytes .
2226777	0	prostaglandins	55,69	N-myc	0,5	prostaglandins	N-myc	MESH:D011453	4613	Chemical	Gene	suppression|nmod|START_ENTITY suppression|compound|END_ENTITY	N-myc suppression and cell cycle arrest at G1 phase by prostaglandins .
23603366	0	prostaglandins	23,37	PGD2	58,62	prostaglandins	PGD2	MESH:D011453	5730	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Yin-Yang regulation of prostaglandins and nitric_oxide by PGD2 in human arthritis : reversal by celecoxib .
2847201	0	prostaglandins	72,86	PGD2	100,104	prostaglandins	PGD2	MESH:D011453	5730	Chemical	Gene	START_ENTITY|appos|PGE1 PGE1|dep|END_ENTITY	Role of adenosine_3 ' 5 ' - cyclic_monophosphate in antineoplastic effect of prostaglandins -LRB- PGE1 , PGE2 , PGD2 and PGA1 -RRB- on human neuroblastoma cells .
9448742	0	prostaglandins	54,68	Phospholipase_A2	0,16	prostaglandins	Phospholipase A2	MESH:D011453	18784(Tax:10090)	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Phospholipase_A2 activation and increases in specific prostaglandins in the oxidatively stressed 14CoS/14CoS mouse hepatocyte line .
6997808	0	prostaglandins	66,80	Renin	1,6	prostaglandins	Renin	MESH:D011453	24715(Tax:10116)	Chemical	Gene	-RSB-|amod|START_ENTITY influence|nmod|-RSB- secretion|nmod|influence secretion|nsubj|END_ENTITY	-LSB- Renin secretion by rat and rabbit kidneys under the influence of prostaglandins -RSB- .
18523308	0	prostaglandins	33,47	TLR2	14,18	prostaglandins	TLR2	MESH:D011453	7097	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of TLR2 expression by prostaglandins in brain_glia .
6195481	0	prostaglandins	8,22	angiotensin-converting_enzyme	48,77	prostaglandins	angiotensin-converting enzyme	MESH:D011453	610668(Tax:9615)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|inhibition inhibition|amod|END_ENTITY	Role of prostaglandins in the renal response to angiotensin-converting_enzyme inhibition and renal_artery_occlusion .
3447251	0	prostaglandins	41,55	angiotensin_II	17,31	prostaglandins	angiotensin II	MESH:D011453	24179(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY effects|dep|role effects|nmod|END_ENTITY	Renal effects of angiotensin_II : role of prostaglandins ?
3518789	0	prostaglandins	15,29	angiotensin_II	58,72	prostaglandins	angiotensin II	MESH:D011453	183	Chemical	Gene	actions|nmod|START_ENTITY actions|nmod|END_ENTITY	The actions of prostaglandins and their interactions with angiotensin_II in the isolated perfused human placental cotyledon .
6391178	0	prostaglandins	7,21	angiotensin_II	57,71	prostaglandins	angiotensin II	MESH:D011453	183	Chemical	Gene	START_ENTITY|nmod|infusion infusion|nmod|END_ENTITY	Plasma prostaglandins during the intravenous infusion of angiotensin_II in pregnant women .
897209	0	prostaglandins	8,22	angiotensin_II	69,83	prostaglandins	angiotensin II	MESH:D011453	24179(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of prostaglandins in the mediation of systemic tachyphylaxis to angiotensin_II .
6962466	0	prostaglandins	14,28	arginine_vasopressin	61,81	prostaglandins	arginine vasopressin	MESH:D011453	403579(Tax:9615)	Chemical	Gene	START_ENTITY|nmod|action action|nmod|END_ENTITY	Modulation by prostaglandins of the renal vascular action of arginine_vasopressin .
7460817	0	prostaglandins	14,28	arginine_vasopressin	47,67	prostaglandins	arginine vasopressin	MESH:D011453	100716009	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of prostaglandins on the release of arginine_vasopressin from the guinea_pig hypothalamo-neurohypophyseal complex in organ culture .
2971617	0	prostaglandins	8,22	atrial_natriuretic_factor	57,82	prostaglandins	atrial natriuretic factor	MESH:D011453	608289(Tax:9615)	Chemical	Gene	START_ENTITY|acl|mediating mediating|dobj|effects effects|nmod|END_ENTITY	Role of prostaglandins in mediating the renal effects of atrial_natriuretic_factor .
1149403	0	prostaglandins	88,102	bradykinin	15,25	prostaglandins	bradykinin	MESH:D011453	3827	Chemical	Gene	relationships|nmod|START_ENTITY actions|dep|relationships actions|nmod|END_ENTITY	The actions of bradykinin and eledoisin in the canine isolated kidney : relationships to prostaglandins .
1282633	0	prostaglandins	8,22	bradykinin	56,66	prostaglandins	bradykinin	MESH:D011453	3827	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|inhibitors inhibitors|compound|END_ENTITY	Role of prostaglandins in the cardiovascular effects of bradykinin and angiotensin-converting enzyme inhibitors .
3812104	0	prostaglandins	50,64	bradykinin	34,44	prostaglandins	bradykinin	MESH:D011453	478666(Tax:9615)	Chemical	Gene	modes|nmod|START_ENTITY modes|nmod|END_ENTITY	Different modes of interaction of bradykinin with prostaglandins in pain and acute inflammation .
3925124	0	prostaglandins	19,33	bradykinin	51,61	prostaglandins	bradykinin	MESH:D011453	478666(Tax:9615)	Chemical	Gene	START_ENTITY|nmod|action action|nmod|END_ENTITY	Permissive role of prostaglandins in the action of bradykinin on the pancreas of anesthetized dogs .
4043214	0	prostaglandins	8,22	bradykinin	79,89	prostaglandins	bradykinin	MESH:D011453	3827	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|action action|nmod|END_ENTITY	Role of prostaglandins and the areas postrema in the central pressor action of bradykinin .
474758	0	prostaglandins	22,36	bradykinin	66,76	prostaglandins	bradykinin	MESH:D011453	478666(Tax:9615)	Chemical	Gene	Contribution|nmod|START_ENTITY Contribution|nmod|action action|nmod|END_ENTITY	Contribution of renal prostaglandins to the natriuretic action of bradykinin in the dog .
636947	0	prostaglandins	11,25	bradykinin	56,66	prostaglandins	bradykinin	MESH:D011453	3827	Chemical	Gene	START_ENTITY|acl|mediating mediating|dobj|potentiation potentiation|nmod|END_ENTITY	Release of prostaglandins mediating the potentiation of bradykinin by BPF and chymotrypsin in rate isolated ileum -LSB- proceedings -RSB- .
7449252	0	prostaglandins	107,121	bradykinin	14,24	prostaglandins	bradykinin	MESH:D011453	478666(Tax:9615)	Chemical	Gene	relationship|nmod|START_ENTITY Inhibition|dep|relationship Inhibition|nmod|END_ENTITY	Inhibition of bradykinin of the vascular effects of pressor hormones in the canine kidney : relationship to prostaglandins .
8945723	0	prostaglandins	130,144	c-fos	86,91	prostaglandins	c-fos	MESH:D011453	314322(Tax:10116)	Chemical	Gene	involvement|nmod|START_ENTITY Effect|dep|involvement Effect|nmod|injection injection|nmod|expression expression|amod|interleukin-1_beta interleukin-1_beta|nmod|END_ENTITY	Effect of central and continuous intravenous injection of interleukin-1_beta on brain c-fos expression in the rat : involvement of prostaglandins .
9450688	0	prostaglandins	50,64	c-fos	72,77	prostaglandins	c-fos	MESH:D011453	314322(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Principal involvement of cyclooxygenase-1-derived prostaglandins in the c-fos expression of the rat hind brain following visceral stimulation with acetic_acid .
2105952	1	prostaglandins	200,214	c-myc	180,185	prostaglandins	c-myc	MESH:D011453	4609	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|expression expression|amod|END_ENTITY	Modulation of EGF-dependent c-myc expression by prostaglandins .
9408232	0	prostaglandins	80,94	corticotropin-releasing_factor	46,76	prostaglandins	corticotropin-releasing factor	MESH:D011453	1392	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of human placental corticotropin-releasing_factor by prostaglandins and estradiol .
23416211	0	prostaglandins	127,141	cyclooxygenase-2	92,108	prostaglandins	cyclooxygenase-2	MESH:D011453	19225(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	A catalytically-inactive snake venom Lys49 phospholipase_A homolog induces expression of cyclooxygenase-2 and production of prostaglandins through selected signaling pathways in macrophages .
9012840	0	prostaglandins	114,128	cyclooxygenase-2	73,89	prostaglandins	cyclooxygenase-2	MESH:D011453	5743	Chemical	Gene	release|nmod|START_ENTITY release|amod|END_ENTITY	Epidermal_growth_factor_receptor activation induces nuclear targeting of cyclooxygenase-2 , basolateral release of prostaglandins , and mitogenesis in polarizing colon_cancer cells .
16926398	0	prostaglandins	139,153	cyclooxygenase_2	85,101	prostaglandins	cyclooxygenase 2	MESH:D011453	5743	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Infection of human endothelial cells with spotted Fever group rickettsiae stimulates cyclooxygenase_2 expression and release of vasoactive prostaglandins .
18438856	0	prostaglandins	92,106	cyclooxygenase_2	38,54	prostaglandins	cyclooxygenase 2	MESH:D011453	19225(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Predominance Predominance|nmod|cyclooxygenase_1 cyclooxygenase_1|nmod|END_ENTITY	Predominance of cyclooxygenase_1 over cyclooxygenase_2 in the generation of proinflammatory prostaglandins in autoantibody-driven K/BxN serum-transfer arthritis .
6451899	0	prostaglandins	11,25	diamine_oxidase	65,80	prostaglandins	diamine oxidase	MESH:D011453	26	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of prostaglandins on peripheral progesterone and uterine diamine_oxidase in the pregnant hamster .
1988651	0	prostaglandins	70,84	endothelin-1	40,52	prostaglandins	endothelin-1	MESH:D011453	403424(Tax:9615)	Chemical	Gene	role|nmod|START_ENTITY responses|dep|role responses|nmod|END_ENTITY	Renal and femoral vascular responses to endothelin-1 in dogs : role of prostaglandins .
8794819	0	prostaglandins	9,23	endothelin-1	58,70	prostaglandins	endothelin-1	MESH:D011453	403424(Tax:9615)	Chemical	Gene	Roles|nmod|START_ENTITY Roles|nmod|effect effect|nmod|END_ENTITY	Roles of prostaglandins and nitric_oxide in the effect of endothelin-1 on renal hemodynamics .
213236	0	prostaglandins	75,89	erythropoietin	50,64	prostaglandins	erythropoietin	MESH:D011453	13856(Tax:10090)	Chemical	Gene	concept|nmod|START_ENTITY concept|nmod|END_ENTITY	A concept for the control of kidney production of erythropoietin involving prostaglandins and cyclic nucleotides .
2990227	0	prostaglandins	8,22	erythropoietin	45,59	prostaglandins	erythropoietin	MESH:D011453	24335(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|production production|compound|END_ENTITY	Role of prostaglandins in hypoxia-stimulated erythropoietin production .
3079674	0	prostaglandins	103,117	erythropoietin	18,32	prostaglandins	erythropoietin	MESH:D011453	24335(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY Mode|dep|role Mode|nmod|action action|nmod|END_ENTITY	Mode of action of erythropoietin and glucocorticoids on the hepatic erythroid precursor cells : role of prostaglandins .
3339271	0	prostaglandins	30,44	erythropoietin	59,73	prostaglandins	erythropoietin	MESH:D011453	24335(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Effect of indomethacin and of prostaglandins on extrarenal erythropoietin production in rats .
7399607	0	prostaglandins	20,34	erythropoietin	77,91	prostaglandins	erythropoietin	MESH:D011453	2056	Chemical	Gene	Effect|nmod|START_ENTITY _|nsubj|Effect _|nmod|formation formation|nmod|END_ENTITY	Effect of different prostaglandins _ methyl_testosterone on the formation of erythropoietin by kidney .
2311372	0	prostaglandins	29,43	growth_hormone	68,82	prostaglandins	growth hormone	MESH:D011453	378781(Tax:9031)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|secretion secretion|amod|END_ENTITY	Influence of catecholamines , prostaglandins and thyroid hormones on growth_hormone secretion by chicken pituitary cells in vitro .
3015304	0	prostaglandins	64,78	haptoglobin	128,139	prostaglandins	haptoglobin	MESH:D011453	24464(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of endogenous pyrogen , corticosteroids and inhibitors of prostaglandins and leukotrienes on the plasma concentrations of haptoglobin and fibrinogen in rats .
11525800	0	prostaglandins	105,119	interleukin-1beta	24,41	prostaglandins	interleukin-1beta	MESH:D011453	3553	Chemical	Gene	role|nmod|START_ENTITY clearance|dep|role clearance|amod|END_ENTITY	Intracerebroventricular interleukin-1beta impairs clearance of tumor cells from the lungs : role of brain prostaglandins .
15298980	0	prostaglandins	26,40	interleukin-1beta	83,100	prostaglandins	interleukin-1beta	MESH:D011453	3553	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Independent regulation of prostaglandins and monocyte_chemoattractant_protein-1 by interleukin-1beta and hCG in human endometrial cells .
9801384	0	prostaglandins	99,113	interleukin-1beta	61,78	prostaglandins	interleukin-1beta	MESH:D011453	24494(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY Activation|dep|role Activation|nmod|afferents afferents|nmod|injection injection|nmod|END_ENTITY	Activation of vagal afferents after intravenous injection of interleukin-1beta : role of endogenous prostaglandins .
8007951	0	prostaglandins	76,90	interleukin-6	36,49	prostaglandins	interleukin-6	MESH:D011453	16193(Tax:10090)	Chemical	Gene	mediate|nmod|START_ENTITY mediate|nsubj|elements elements|nmod|gene gene|amod|END_ENTITY	Multiple regulatory elements in the interleukin-6 gene mediate induction by prostaglandins , cyclic_AMP , and lipopolysaccharide .
9578149	0	prostaglandins	59,73	interleukin-6	24,37	prostaglandins	interleukin-6	MESH:D011453	16193(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Effect Effect|nmod|vitamin_D3 vitamin_D3|nmod|synthesis synthesis|amod|END_ENTITY	Effect of vitamin_D3 on interleukin-6 synthesis induced by prostaglandins in osteoblasts .
9610845	0	prostaglandins	60,74	interleukin-6	25,38	prostaglandins	interleukin-6	MESH:D011453	16193(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY synthesis|acl|induced synthesis|amod|END_ENTITY	Retinoic_acid suppresses interleukin-6 synthesis induced by prostaglandins in osteoblasts .
12788827	0	prostaglandins	124,138	neurokinin1_receptor	49,69	prostaglandins	neurokinin1 receptor	MESH:D011453	24807(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY expression|dep|role expression|nmod|END_ENTITY	Prostaglandin_E2 increases the expression of the neurokinin1_receptor in adult sensory neurones in culture : a novel role of prostaglandins .
11461938	0	prostaglandins	15,29	nf-kappab	55,64	prostaglandins	nf-kappab	MESH:D011453	4790	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|activation activation|compound|END_ENTITY	Cyclopentenone prostaglandins inhibit cytokine-induced nf-kappab activation and chemokine production by human mesangial cells .
18378017	0	prostaglandins	100,114	orexin-A	27,35	prostaglandins	orexin-A	MESH:D011453	25723(Tax:10116)	Chemical	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|action action|nmod|END_ENTITY	Gastroprotective action of orexin-A against stress-induced gastric_damage is mediated by endogenous prostaglandins , sensory afferent neuropeptides and nitric_oxide .
3109985	0	prostaglandins	89,103	ornithine_decarboxylase	53,76	prostaglandins	ornithine decarboxylase	MESH:D011453	4953	Chemical	Gene	potentiates|nmod|START_ENTITY potentiates|dobj|induction induction|nmod|activity activity|amod|END_ENTITY	Epidermal_growth_factor potentiates the induction of ornithine_decarboxylase activity by prostaglandins in embryonic_palate mesenchymal cells : effects on cell proliferation and glycosaminoglycan synthesis .
6252576	0	prostaglandins	10,24	ornithine_decarboxylase	28,51	prostaglandins	ornithine decarboxylase	MESH:D011453	24609(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effect of prostaglandins on ornithine_decarboxylase activity in the testis of immature rat .
866364	0	prostaglandins	100,114	phospholipase_A2	14,30	prostaglandins	phospholipase A2	MESH:D011453	151056	Chemical	Gene	action|nmod|START_ENTITY action|nmod|END_ENTITY	The action of phospholipase_A2 on parameters of cardiac contraction , excitation and biosynthesis of prostaglandins .
9237867	0	prostaglandins	60,74	phospholipase_A2	129,145	prostaglandins	phospholipase A2	MESH:D011453	151056	Chemical	Gene	START_ENTITY|dep|activation activation|nmod|END_ENTITY	Endothelin-1 stimulates the release of arachidonic_acid and prostaglandins in cultured human ciliary muscle cells : activation of phospholipase_A2 .
1650837	0	prostaglandins	42,56	phospholipase_D	14,29	prostaglandins	phospholipase D	MESH:D011453	2822	Chemical	Gene	START_ENTITY|nsubj|Activation Activation|nmod|END_ENTITY	Activation of phospholipase_D by E-series prostaglandins in human erythroleukemia cells .
400384	0	prostaglandins	17,31	prolactin	52,61	prostaglandins	prolactin	MESH:D011453	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|levels levels|nmod|END_ENTITY	-LSB- Effects of some prostaglandins on plasma levels of prolactin in the rat -RSB- .
1077783	0	prostaglandins	10,24	renin	72,77	prostaglandins	renin	MESH:D011453	5972	Chemical	Gene	START_ENTITY|nmod|reaction reaction|nmod|END_ENTITY	Effect of prostaglandins -LRB- E2_and_A2 -RRB- on the enzymatic reaction of human renin in isolated homologous system and with added normal and hypertensive plasma .
2035656	0	prostaglandins	61,75	renin	30,35	prostaglandins	renin	MESH:D011453	24715(Tax:10116)	Chemical	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|modulation modulation|nmod|secretion secretion|compound|END_ENTITY	Protein-induced modulation of renin secretion is mediated by prostaglandins .
2960181	0	prostaglandins	24,38	renin	68,73	prostaglandins	renin	MESH:D011453	5972	Chemical	Gene	role|nmod|START_ENTITY role|nmod|secretion secretion|compound|END_ENTITY	Dual regulatory role of prostaglandins and lipoxygenase products on renin secretion .
3324705	0	prostaglandins	73,87	renin	30,35	prostaglandins	renin	MESH:D011453	24715(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Effect of pregnancy on plasma renin activity and glomerular synthesis of prostaglandins and thromboxane in rats .
3883811	0	prostaglandins	8,22	renin	26,31	prostaglandins	renin	MESH:D011453	24715(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|suppression suppression|compound|END_ENTITY	Role of prostaglandins in renin suppression during acute potassium loading .
398992	0	prostaglandins	28,42	renin	54,59	prostaglandins	renin	MESH:D011453	5972	Chemical	Gene	relationship|nmod|START_ENTITY END_ENTITY|nsubj|relationship	The relationship of urinary prostaglandins and plasma renin to sodium balance and diuresis in normal man .
6251763	4	prostaglandins	494,508	renin	519,524	prostaglandins	renin	MESH:D011453	5972	Chemical	Gene	influence|nsubj|START_ENTITY influence|dobj|release release|compound|END_ENTITY	A more precise definition of the mechanisms whereby prostaglandins influence renin release is given showing that the baroreceptor and the macula densa mechanisms of renin release are affected by prostaglandins .
6251763	4	prostaglandins	637,651	renin	519,524	prostaglandins	renin	MESH:D011453	5972	Chemical	Gene	affected|nmod|START_ENTITY showing|ccomp|affected given|xcomp|showing given|nsubjpass|definition definition|nmod|mechanisms mechanisms|acl:relcl|influence influence|dobj|release release|compound|END_ENTITY	A more precise definition of the mechanisms whereby prostaglandins influence renin release is given showing that the baroreceptor and the macula densa mechanisms of renin release are affected by prostaglandins .
6260459	0	prostaglandins	18,32	renin	40,45	prostaglandins	renin	MESH:D011453	24715(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|response response|compound|END_ENTITY	The role of renal prostaglandins in the renin response to isoproterenol in the rat in vitro .
6269043	0	prostaglandins	12,26	renin	72,77	prostaglandins	renin	MESH:D011453	403838(Tax:9615)	Chemical	Gene	START_ENTITY|nmod|response response|compound|END_ENTITY	The role of prostaglandins in the alpha - and beta-adrenoceptor mediated renin release response to graded renal nerve stimulation .
6275455	0	prostaglandins	47,61	renin	65,70	prostaglandins	renin	MESH:D011453	403838(Tax:9615)	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	Effect of precursors of the 1 , 2 , and 3 series prostaglandins on renin release and renal blood flow in the dog .
6394759	0	prostaglandins	23,37	renin	60,65	prostaglandins	renin	MESH:D011453	5972	Chemical	Gene	excretion|nmod|START_ENTITY excretion|nmod|END_ENTITY	The renal excretion of prostaglandins and changes in plasma renin during treatment with either sulindac or naproxen in patients with rheumatoid_arthritis and thiazide treated heart_failure .
6756707	0	prostaglandins	11,25	renin	71,76	prostaglandins	renin	MESH:D011453	5972	Chemical	Gene	START_ENTITY|acl|inhibition inhibition|nmod|changes changes|nmod|END_ENTITY	Effects of prostaglandins inhibition on changes in active and inactive renin induced by antihypertensive drugs .
6996036	0	prostaglandins	40,54	renin	13,18	prostaglandins	renin	MESH:D011453	5972	Chemical	Gene	START_ENTITY|nsubj|Induction Induction|nmod|release release|compound|END_ENTITY	Induction of renin release by exogenous prostaglandins in hyporeninemic_hypoaldosteronism .
7644529	1	prostaglandins	182,196	renin	226,231	prostaglandins	renin	MESH:D011453	24715(Tax:10116)	Chemical	Gene	involvement|nmod|START_ENTITY examine|dobj|involvement examine|nmod|effect effect|amod|END_ENTITY	This study was designed to examine the possible involvement of prostaglandins and nitric_oxide -LRB- NO -RRB- in the renin stimulatory effect of angiotensin_II -LRB- AngII -RRB- antagonists .
852103	0	prostaglandins	8,22	renin	41,46	prostaglandins	renin	MESH:D011453	403838(Tax:9615)	Chemical	Gene	START_ENTITY|nmod|control control|nmod|secretion secretion|compound|END_ENTITY	Role of prostaglandins in the control of renin secretion in the dog .
6344655	0	prostaglandins	65,79	secretin	10,18	prostaglandins	secretin	MESH:D011453	483407(Tax:9615)	Chemical	Gene	relation|nmod|START_ENTITY Effect|dep|relation Effect|nmod|END_ENTITY	Effect of secretin and caerulein in canine pancreas : relation to prostaglandins .
8420279	0	prostaglandins	19,33	secretin	37,45	prostaglandins	secretin	MESH:D011453	24769(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|amod|END_ENTITY	Role of endogenous prostaglandins in secretin - and plaunotol-induced inhibition of gastric_acid secretion in the rat .
11425333	0	prostaglandins	8,22	transforming_growth_factor_alpha	81,113	prostaglandins	transforming growth factor alpha	MESH:D011453	7124	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of prostaglandins in the suppression of apoptosis in hen granulosa cells by transforming_growth_factor_alpha .
2808538	0	prostaglandins	17,31	tumor_necrosis_factor	80,101	prostaglandins	tumor necrosis factor	MESH:D011453	7124	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Possible role of prostaglandins as negative regulators in growth stimulation by tumor_necrosis_factor and epidermal_growth_factor in human fibroblasts .
1908334	0	prostaglandins	78,92	tumor_necrosis_factor_alpha	127,154	prostaglandins	tumor necrosis factor alpha	MESH:D011453	21926(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	In vitro cytokine release by activated murine peritoneal macrophages : role of prostaglandins in the differential regulation of tumor_necrosis_factor_alpha , interleukin_1 , and interleukin_6 .
9461495	0	prostaglandins	19,33	type-II_phospholipase_A2	37,61	prostaglandins	type-II phospholipase A2	MESH:D011453	100135599(Tax:10141)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Down-regulation by prostaglandins of type-II_phospholipase_A2 expression in guinea-pig alveolar macrophages : a possible involvement of cAMP .
6827269	0	prostaglandins	58,72	vasoactive_intestinal_polypeptide	11,44	prostaglandins	vasoactive intestinal polypeptide	MESH:D011453	117064(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of vasoactive_intestinal_polypeptide , monoamines , prostaglandins , and 2-chloroadenosine on adenylate cyclase in rat cerebral microvessels .
6573182	0	prostaglandins	15,29	vasopressin	33,44	prostaglandins	vasopressin	MESH:D011453	551	Chemical	Gene	START_ENTITY|nmod|stimulation stimulation|compound|END_ENTITY	Involvement of prostaglandins in vasopressin stimulation of the human uterus .
11393218	0	prostaglandins_E2_and_F2alpha	55,84	tumor_necrosis_factor-alpha	11,38	prostaglandins E2 and F2alpha	tumor necrosis factor-alpha	null	280943(Tax:9913)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of tumor_necrosis_factor-alpha on secretion of prostaglandins_E2_and_F2alpha in bovine endometrium throughout the estrous cycle .
6750695	0	prostaglandins_E2_and_I2	58,82	angiotensin_ii	10,24	prostaglandins E2 and I2	angiotensin ii	null	24179(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of angiotensin_ii and norepinephrine on release of prostaglandins_E2_and_I2 by the perfused rat mesenteric artery .
8955561	0	prostaglandins_E_and_F2_alpha	120,149	histone-H2A	10,21	prostaglandins E and F2 alpha	histone-H2A	null	100299831	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of histone-H2A -LRB- H-H2A -RRB- , platelet activating factor -LRB- PAF -RRB- and pregnancy_specific_protein_B -LRB- PSPB -RRB- on secretion of prostaglandins_E_and_F2_alpha -LRB- PGE ; PGF2 alpha -RRB- by bovine endometrium and H-H2A on basal secretion of luteinizing hormone -LRB- LH -RRB- by bovine pituitary cells in vitro .
16008217	0	prostanoid	82,92	cyclooxygenase	46,60	prostanoid	cyclooxygenase	CHEBI:26347	403544(Tax:9615)	Chemical	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	In vivo effects of tepoxalin , an inhibitor of cyclooxygenase and lipoxygenase , on prostanoid and leukotriene production in dogs with chronic_osteoarthritis .
8062861	0	prostanoids	79,90	Bradykinin	0,10	prostanoids	Bradykinin	MESH:D011453	3827	Chemical	Gene	release|nmod|START_ENTITY stimulate|dobj|release stimulate|nsubj|END_ENTITY	Bradykinin and thrombin stimulate release of arachidonic_acid and formation of prostanoids in human periodontal ligament cells .
19237150	0	prostanoids	39,50	Nur77	14,19	prostanoids	Nur77	MESH:D011453	15370(Tax:10090)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of Nur77 gene expression by prostanoids in cementoblastic cells .
19552966	0	prostanoids	83,94	cortistatin	21,32	prostanoids	cortistatin	MESH:D011453	25305(Tax:10116)	Chemical	Gene	production|nmod|START_ENTITY effects|nmod|production effects|nmod|END_ENTITY	Diverging effects of cortistatin and somatostatin on the production and release of prostanoids from rat cortical microglia and astrocytes .
9795252	0	prostanoids	14,25	cyclo-oxygenase-2	40,57	prostanoids	cyclo-oxygenase-2	MESH:D011453	5743	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Production of prostanoids via increased cyclo-oxygenase-2 expression in human amnion cells in response to low molecular weight hyaluronic acid fragment .
12900348	0	prostanoids	57,68	cyclooxygenase-2	8,24	prostanoids	cyclooxygenase-2	MESH:D011453	29527(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of cyclooxygenase-2 in the generation of vasoactive prostanoids in the rat pulmonary and systemic vascular beds .
1725341	0	prostanoids	59,70	endothelin-1	11,23	prostanoids	endothelin-1	MESH:D011453	24323(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|acl|END_ENTITY	Effects of endothelin-1 and endothelin-3 on the release of prostanoids from isolated perfused rat kidney .
15051033	0	prostanoids	45,56	interleukin-6	18,31	prostanoids	interleukin-6	MESH:D011453	3569	Chemical	Gene	secretion|nmod|START_ENTITY secretion|amod|END_ENTITY	The regulation of interleukin-6 secretion by prostanoids and members of the tumor necrosis factor superfamily in fresh villous fragments of term human placenta .
1484418	0	prostate_acid	29,42	PAP	24,27	prostate acid	PAP	null	11333	Chemical	Gene	phosphatase|amod|START_ENTITY END_ENTITY|appos|phosphatase	-LSB- Relation between serum PAP -LRB- prostate_acid phosphatase -RRB- and bone scintigraphy in prostatic_cancer -RSB- .
17014716	0	prostratin	11,21	Cyclin_T1	25,34	prostratin	Cyclin T1	MESH:C070999	904	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of prostratin on Cyclin_T1 / P-TEFb function and the gene expression profile in primary resting CD4 + T cells .
3180741	0	protamine	38,47	C5a_receptor	11,23	protamine	C5a receptor	null	728	Chemical	Gene	antagonism|nmod|START_ENTITY antagonism|nsubj|END_ENTITY	Complement C5a_receptor antagonism by protamine and poly-L-Arg on human leukocytes .
20016815	0	protamine	70,79	RyR2	61,65	protamine	RyR2	null	6262	Chemical	Gene	modulation|nmod|START_ENTITY modulation|appos|END_ENTITY	Voltage-dependent modulation of cardiac ryanodine receptors -LRB- RyR2 -RRB- by protamine .
22455130	0	protamine	11,20	VEGF	24,28	protamine	VEGF	null	83785(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	-LSB- Effect of protamine on VEGF expression in vitreous and serum of rats with diabetic -RSB- .
8925890	0	protamine	71,80	chymase	10,17	protamine	chymase	null	1215	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Mast cell chymase in complex with heparin proteoglycan is regulated by protamine .
7818503	0	protamine	10,19	lipoprotein_lipase	23,41	protamine	lipoprotein lipase	null	24539(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of protamine on lipoprotein_lipase and hepatic_lipase in rats .
7225294	0	protamine	14,23	placental_protein_5	43,62	protamine	placental protein 5	null	7980	Chemical	Gene	START_ENTITY|nmod|levels levels|nmod|END_ENTITY	The effect of protamine on serum levels of placental_protein_5 -LRB- PP5 -RRB- in normal and abnormal pregnancy : a possible relation to coagulation_abnormalities .
18314125	0	protamine	33,42	protamine_2	48,59	protamine	protamine 2	null	5620	Chemical	Gene	START_ENTITY|nmod|ratio ratio|amod|END_ENTITY	Protamine_2 precursors -LRB- Pre-P2 -RRB- , protamine 1 to protamine_2 ratio -LRB- P1/P2 -RRB- , and assisted reproduction outcome .
2303128	0	protamine_sulfate	64,81	CSF	29,32	protamine sulfate	CSF	null	116630(Tax:10116)	Chemical	Gene	infusion|nmod|START_ENTITY END_ENTITY|nmod|infusion	Albumin content in brain and CSF after intracarotid infusion of protamine_sulfate : a longitudinal study .
20238034	12	protamine_sulfate	1889,1906	VEGF	1921,1925	protamine sulfate	VEGF	null	7422	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|END_ENTITY	In this study we showed that protamine_sulfate could inhibit VEGF and the binding of VEGF and its receptor , implying that protamine_sulfate may inhibit blood vessel growth through inhibition of the VEGF pathway .
6846326	0	protamine_sulfate	15,32	thrombin	38,46	protamine sulfate	thrombin	null	2147	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of protamine_sulfate with thrombin .
923094	0	protamine_sulphate	10,28	lipoprotein_lipase	45,63	protamine sulphate	lipoprotein lipase	null	4023	Chemical	Gene	inactivation|compound|START_ENTITY inactivation|nmod|END_ENTITY	Selective protamine_sulphate inactivation of lipoprotein_lipase and hepatic_lipase in human post-heparin plasma : specific lipase levels in normals and in type_I_hyperlipoproteinaemia .
23627096	0	protocatechuic_acid	26,45	APP	72,75	protocatechuic acid	APP	MESH:C009091	100689222	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- The inhibition effect of protocatechuic_acid on the mRNA expression of APP on M146L cell -RSB- .
24757420	0	protocatechuic_acid	45,64	p66shc	15,21	protocatechuic acid	p66shc	MESH:C009091	20416(Tax:10090)	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Modulating the p66shc signaling pathway with protocatechuic_acid protects the intestine from ischemia-reperfusion injury and alleviates secondary liver_damage .
11023549	0	protocatechuic_acid	30,49	tyrosinase	196,206	protocatechuic acid	tyrosinase	MESH:C009091	22173(Tax:10090)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	A simple phenolic antioxidant protocatechuic_acid enhances tumor promotion and oxidative stress in female ICR mouse skin : dose-and timing-dependent enhancement and involvement of bioactivation by tyrosinase .
15154289	0	protocatechuic_aldehyde	28,51	tyrosinase	14,24	protocatechuic aldehyde	tyrosinase	MESH:C005581	7299	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of tyrosinase by protocatechuic_aldehyde .
8624514	0	protochlorophyllide	41,60	POR	78,81	protochlorophyllide	POR	MESH:D011521	830151(Tax:3702)	Chemical	Gene	oxidoreductases|amod|START_ENTITY oxidoreductases|appos|END_ENTITY	Distinct roles for light-dependent NADPH : protochlorophyllide oxidoreductases -LRB- POR -RRB- A and B during greening in higher plants .
20012672	0	protochlorophyllide	12,31	PORA	50,54	protochlorophyllide	PORA	MESH:D011521	835507(Tax:3702)	Chemical	Gene	A|amod|START_ENTITY A|appos|END_ENTITY	Arabidopsis protochlorophyllide oxidoreductase A -LRB- PORA -RRB- restores bulk chlorophyll synthesis and normal development to a porB porC double mutant .
22278767	0	protochlorophyllide	28,47	PORA	66,70	protochlorophyllide	PORA	MESH:D011521	835507(Tax:3702)	Chemical	Gene	A|compound|START_ENTITY A|appos|END_ENTITY	Arabidopsis light-dependent protochlorophyllide oxidoreductase A -LRB- PORA -RRB- is essential for normal plant growth and development .
14581621	0	protochlorophyllide	42,61	PORB	84,88	protochlorophyllide	PORB	MESH:D011521	828853(Tax:3702)	Chemical	Gene	oxidoreductase|amod|START_ENTITY oxidoreductase|appos|END_ENTITY	Functional analysis of isoforms of NADPH : protochlorophyllide oxidoreductase -LRB- POR -RRB- , PORB and PORC , in Arabidopsis_thaliana .
25704023	0	protopanaxadiol	63,78	TRAIL	0,5	protopanaxadiol	TRAIL	MESH:C062916	8743	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	TRAIL pathway is associated with inhibition of colon_cancer by protopanaxadiol .
1332695	0	protoporphyrin	22,36	cytochrome_P-450	44,60	protoporphyrin	cytochrome P-450	CHEBI:15430	25251(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|system system|amod|END_ENTITY	Toxic dark effects of protoporphyrin on the cytochrome_P-450 system in rat liver microsomes .
17174393	15	protoporphyrin_IX	1953,1970	PBR	1941,1944	protoporphyrin IX	PBR	MESH:C028025	24230(Tax:10116)	Chemical	Gene	ligand|appos|START_ENTITY ligand|compound|END_ENTITY	The endogenous PBR ligand , protoporphyrin_IX , facilitated PTP opening and phosphorylation of the mitochondrial proteins , thus , inducing effects opposite to anti-PBR antibody .
11986241	0	protoporphyrin_IX	30,47	frataxin	62,70	protoporphyrin IX	frataxin	MESH:C028025	2395	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Erythroid differentiation and protoporphyrin_IX down-regulate frataxin expression in Friend cells : characterization of frataxin expression compared to molecules involved in iron metabolism and hemoglobinization .
22862424	0	protoporphyrin_IX	96,113	frataxin	32,40	protoporphyrin IX	frataxin	MESH:C028025	2395	Chemical	Gene	accumulation|nmod|START_ENTITY controls|dobj|accumulation controls|nsubj|expression expression|nmod|END_ENTITY	The p53-dependent expression of frataxin controls 5-aminolevulinic_acid-induced accumulation of protoporphyrin_IX and photo-damage in cancerous cells .
17464175	5	protoporphyrin_IX	855,872	heme	826,830	protoporphyrin IX	HO-1	MESH:C028025	3162	Chemical	Gene	activity|dep|START_ENTITY activity|amod|END_ENTITY	In additional experiments , an inhibitor of heme oxygenase activity -LRB- tin protoporphyrin_IX , 10 microM -RRB- or siRNA for HO-1 were used to investigate the participation of HO-1 as a mediator of curcumin-induced effects .
19101161	0	protoporphyrin_IX	89,106	peripheral-type_benzodiazepine_receptor	16,55	protoporphyrin IX	peripheral-type benzodiazepine receptor	MESH:C028025	706	Chemical	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of peripheral-type_benzodiazepine_receptor with diamino_acid derivatives of protoporphyrin_IX .
1327514	0	provitamin_A	72,84	connexin43	24,34	provitamin A	connexin43	CHEBI:67200	14609(Tax:10090)	Chemical	Gene	independent|nmod|START_ENTITY independent|amod|END_ENTITY	Carotenoids up-regulate connexin43 gene expression independent of their provitamin_A or antioxidant properties .
26937219	0	prunetin	11,19	MMP-3	115,120	prunetin	MMP-3	MESH:C083295	100009111(Tax:9986)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of prunetin on the proteolytic activity , secretion and gene expression of MMP-3 in vitro and production of MMP-3 in vivo .
26937219	0	prunetin	11,19	MMP-3	82,87	prunetin	MMP-3	MESH:C083295	100009111(Tax:9986)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of prunetin on the proteolytic activity , secretion and gene expression of MMP-3 in vitro and production of MMP-3 in vivo .
15853801	2	psbO	262,266	PsbO1	305,310	psbO	PsbO1	null	836789(Tax:3702)	Chemical	Gene	genes|amod|START_ENTITY genes|dep|END_ENTITY	Arabidopsis_thaliana has two psbO genes that express two PsbO proteins ; PsbO1 and PsbO2 .
21559677	0	psc-833	91,98	p-glycoprotein	13,27	psc-833	p-glycoprotein	MESH:C070272	5243	Chemical	Gene	mediated|nmod|START_ENTITY mediated|nsubj|Reversion Reversion|nmod|END_ENTITY	Reversion of p-glycoprotein mediated multidrug-resistance to vincristine and adriamycin by psc-833 , a cyclosporine derivative in human neuroblastoma cell-lines .
16953122	0	pseudolaric_acid_B	76,94	p53	69,72	pseudolaric acid B	p53	MESH:C058391	7157	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of JNK-initiated p53 accumulation and phosphorylation of p53 in pseudolaric_acid_B induced cell death .
9430663	0	pseudouridine	42,55	Deg1	34,38	pseudouridine	Deg1	MESH:D011560	850550(Tax:4932)	Chemical	Gene	synthase|amod|START_ENTITY END_ENTITY|nmod|synthase	Characterization of yeast protein Deg1 as pseudouridine synthase -LRB- Pus3 -RRB- catalyzing the formation of psi 38 and psi 39 in tRNA anticodon loop .
15108122	0	pseudouridine	21,34	PUS1	47,51	pseudouridine	PUS1	MESH:D011560	80324	Chemical	Gene	synthase|compound|START_ENTITY mutation|nmod|synthase mutation|appos|END_ENTITY	Missense mutation in pseudouridine synthase 1 -LRB- PUS1 -RRB- causes mitochondrial_myopathy_and_sideroblastic_anemia -LRB- MLASA -RRB- .
15772074	0	pseudouridine	82,95	PUS1	108,112	pseudouridine	PUS1	MESH:D011560	80324	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mitochondrial_myopathy_and_sideroblastic_anemia -LRB- MLASA -RRB- : missense mutation in the pseudouridine synthase 1 -LRB- PUS1 -RRB- gene is associated with the loss of tRNA pseudouridylation .
23707380	0	pseudouridine	9,22	Pus1	130,134	pseudouridine	Pus1	MESH:D011560	80324	Chemical	Gene	blocks|nmod|START_ENTITY blocks|nmod|TruA TruA|amod|binding binding|nmod|orientation orientation|nmod|homologue homologue|amod|END_ENTITY	In human pseudouridine synthase 1 -LRB- hPus1 -RRB- , a C-terminal helical insert blocks tRNA from binding in the same orientation as in the Pus1 bacterial homologue TruA , consistent with their different target selectivities .
9430663	0	pseudouridine	42,55	Pus3	66,70	pseudouridine	Pus3	MESH:D011560	850550(Tax:4932)	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	Characterization of yeast protein Deg1 as pseudouridine synthase -LRB- Pus3 -RRB- catalyzing the formation of psi 38 and psi 39 in tRNA anticodon loop .
9358157	0	pseudouridine	33,46	Pus4	57,61	pseudouridine	Pus4	MESH:D011560	855424(Tax:4932)	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	The yeast gene YNL292w encodes a pseudouridine synthase -LRB- Pus4 -RRB- catalyzing the formation of psi55 in both mitochondrial and cytoplasmic tRNAs .
1304460	0	psoralen	22,30	MEC-1	69,74	psoralen	MEC-1	MESH:D005363	545	Chemical	Gene	activity|nmod|START_ENTITY activity|nmod|END_ENTITY	Antitumor activity of psoralen on mucoepidermoid_carcinoma cell line MEC-1 .
3582276	0	psoralen	13,21	NAT	25,28	psoralen	NAT	MESH:D005363	116631(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Influence of psoralen on NAT activity and melatonin levels in rat pineal gland during the daily period of darkness .
24871658	0	psoralen	53,61	Th2	65,68	psoralen	Th2	MESH:D005363	15111(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|response response|amod|END_ENTITY	Effects of Psoraleae fructus and its major component psoralen on Th2 response in allergic_asthma .
19223576	4	psoralidin	673,683	Akt	700,703	psoralidin	Akt	MESH:C102768	207	Chemical	Gene	compound|appos|START_ENTITY compound|acl:relcl|inhibits inhibits|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Recently , we identified a natural compound , psoralidin , which inhibits Akt phosphorylation , and its consequent activation in androgen-independent_prostate_cancer -LRB- AIPC -RRB- cells .
19641888	0	psoralidin	43,53	quinone_reductase	13,30	psoralidin	quinone reductase	MESH:C102768	12972(Tax:10090)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Induction of quinone_reductase activity by psoralidin isolated from Psoralea corylifolia in mouse hepa 1c1c7 cells .
22643355	0	psoralidin	13,23	tumor_necrosis_factor-related_apoptosis-inducing_ligand	54,109	psoralidin	tumor necrosis factor-related apoptosis-inducing ligand	MESH:C102768	8743	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|effect effect|nmod|END_ENTITY	The coumarin psoralidin enhances anticancer effect of tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- .
23761900	0	psychosine	17,27	GSK3b	94,99	psychosine	GSK3b	MESH:D011609	56637(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|activation activation|nmod|END_ENTITY	The sphingolipid psychosine inhibits fast axonal transport in Krabbe_disease by activation of GSK3b and deregulation of molecular motors .
17696965	0	psychosine	114,124	TNF-alpha	10,19	psychosine	TNF-alpha	MESH:D011609	7124	Chemical	Gene	effect|nmod|START_ENTITY production|dep|effect production|amod|END_ENTITY	Increased TNF-alpha production by peripheral blood mononuclear cells in patients with Krabbe 's _ disease : effect of psychosine .
18332401	0	psyllium	10,18	C-reactive_protein	44,62	psyllium	C-reactive protein	MESH:D011620	1401	Chemical	Gene	supplementation|compound|START_ENTITY supplementation|nmod|END_ENTITY	Effect of psyllium fiber supplementation on C-reactive_protein : the trial to reduce inflammatory markers -LRB- TRIM -RRB- .
25391814	0	psyllium	11,19	LDL-cholesterol	23,38	psyllium	LDL-cholesterol	MESH:D011620	22796	Chemical	Gene	START_ENTITY|nmod|concentrations concentrations|amod|END_ENTITY	Effects of psyllium on LDL-cholesterol concentrations in Brazilian children and adolescents : a randomised , placebo-controlled , parallel clinical trial .
6033638	0	pteridine	35,44	dopamine-beta-hydroxylase	48,73	pteridine	dopamine-beta-hydroxylase	CHEBI:27601	1621	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|amod|END_ENTITY	The effect of reduced and oxidized pteridine on dopamine-beta-hydroxylase activity .
10749677	0	pteridine_5-methyltetrahydrobiopterin	116,153	nitric_oxide_synthase	48,69	pteridine 5-methyltetrahydrobiopterin	nitric oxide synthase	null	4843	Chemical	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	Nitric_oxide-induced autoinhibition of neuronal nitric_oxide_synthase in the presence of the autoxidation-resistant pteridine_5-methyltetrahydrobiopterin .
3840051	0	pteroic_acid	46,58	folypolyglutamate_synthetase	14,42	pteroic acid	folypolyglutamate synthetase	MESH:C005584	2356	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of folypolyglutamate_synthetase by pteroic_acid .
18272370	0	pterostilbene	64,77	PPARalpha	93,102	pterostilbene	PPARalpha	MESH:C107773	5465	Chemical	Gene	analogs|amod|START_ENTITY analogs|nmod|END_ENTITY	Design , synthesis , biological evaluation and docking studies of pterostilbene analogs inside PPARalpha .
23838680	0	pterygium	30,39	CREB	14,18	pterygium	CREB	null	1385	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of CREB in primary pterygium and correlation with cyclin_D1 , ki-67 , MMP7 , p53 , p63 , Survivin and Vimentin .
18050111	0	pterygium	53,62	Cyclooxygenase-2	0,16	pterygium	Cyclooxygenase-2	null	5743	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Cyclooxygenase-2 expression in primary and recurrent pterygium .
17515883	0	pterygium	31,40	Cyclooxygenase_2	0,16	pterygium	Cyclooxygenase 2	null	5743	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Cyclooxygenase_2 expression in pterygium .
19223989	0	pterygium	43,52	S100	16,20	pterygium	S100	null	6271	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Calcium-binding S100 protein expression in pterygium .
17444036	0	pterygium	72,81	VEGF	64,68	pterygium	VEGF	null	7422	Chemical	Gene	-RSB-|compound|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- Blood vessel multiply and significance of expression of Cox-2 , VEGF in pterygium -RSB- .
24123908	0	pterygium	99,108	Vascular_endothelial_growth_factor	0,34	pterygium	Vascular endothelial growth factor	null	7422	Chemical	Gene	polymorphism|nmod|START_ENTITY polymorphism|amod|END_ENTITY	Vascular_endothelial_growth_factor gene polymorphism and protein expression in the pathogenesis of pterygium .
23838680	0	pterygium	30,39	cyclin_D1	61,70	pterygium	cyclin D1	null	595	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of CREB in primary pterygium and correlation with cyclin_D1 , ki-67 , MMP7 , p53 , p63 , Survivin and Vimentin .
12905904	0	pterygium	93,102	epidermal_growth_factor	23,46	pterygium	epidermal growth factor	null	1950	Chemical	Gene	-RSB-|compound|START_ENTITY Effect|nmod|-RSB- Effect|nmod|END_ENTITY	-LSB- Effect of recombinant epidermal_growth_factor on corneal epithelial cells after excision of pterygium -RSB- .
15968165	0	pterygium	18,27	p53	0,3	pterygium	p53	null	7157	Chemical	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	p53 Expression in pterygium by immunohistochemical analysis : a series report of 127 cases and review of the literature .
19384014	0	pterygium	18,27	p53	0,3	pterygium	p53	null	7157	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	p53 expression in pterygium in two climatic regions in Turkey .
19481369	0	pterygium	96,105	p53	78,81	pterygium	p53	null	7157	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Immunohistochemical analysis of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and p53 expression in pterygium from Tunisian patients .
26964379	0	pterygium	68,77	p53	35,38	pterygium	p53	null	7157	Chemical	Gene	protein|nmod|START_ENTITY protein|compound|END_ENTITY	The expression and significance of p53 protein and Ki-67 protein in pterygium .
9793769	0	pterygium	29,38	p53	14,17	pterygium	p53	null	7157	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|protein protein|compound|END_ENTITY	Expression of p53 protein in pterygium .
23499777	0	pterygium	37,46	peroxiredoxin_2	18,33	pterygium	peroxiredoxin 2	null	7001	Chemical	Gene	Overexpression|nmod|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of peroxiredoxin_2 in pterygium .
17205823	0	puerarin	11,19	ADMA-DDAH	23,32	puerarin	ADMA-DDAH	MESH:C033607	23576	Chemical	Gene	START_ENTITY|nmod|system system|amod|END_ENTITY	-LSB- Effect of puerarin on ADMA-DDAH system in human umbilical vein endothelial cells cultured with oxidized free radical -RSB- .
19086646	0	puerarin	12,20	ADRP	24,28	puerarin	ADRP	MESH:C033607	298199(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effects of puerarin on ADRP gene expression in fatty tissue of type_2_diabetes_mellitus rats -RSB- .
20195825	0	puerarin	15,23	CYP2D6	27,33	puerarin	CYP2D6	MESH:C033607	1565	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activities activities|compound|END_ENTITY	The effects of puerarin on CYP2D6 and CYP1A2 activities in vivo .
23088308	0	puerarin	21,29	GSK-3b	138,144	puerarin	GSK-3b	MESH:C033607	84027(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|involvement involvement|nmod|END_ENTITY	Protective effect of puerarin against beta-amyloid-induced oxidative stress in neuronal_cultures from rat hippocampus : involvement of the GSK-3b / Nrf2 signaling pathway .
18981705	7	puerarin	1168,1176	HSP70	1278,1283	puerarin	HSP70	MESH:C033607	266759(Tax:10116)	Chemical	Gene	limit|nsubj|START_ENTITY limit|dobj|injury injury|acl|caused caused|advcl|improving improving|dobj|expression expression|nmod|END_ENTITY	The results indicated that puerarin can limit the tissue injury caused by local cerebral_ischemia_injury through improving expression of HSP70 , and limit the tissue injury caused by local_cerebral_ischemia-reperfusion through decreasing the Fas expression and improving expression of HSP70 .
16011103	0	puerarin	11,19	Hsp70	41,46	puerarin	Hsp70	MESH:C033607	266759(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of puerarin on the expression of Hsp70 in the rats with cerebral_injury induced by acute local ischemia -RSB- .
20077420	0	puerarin	46,54	MDR1	38,42	puerarin	MDR1	MESH:C033607	5243	Chemical	Gene	mechanism|nmod|START_ENTITY mechanism|nmod|END_ENTITY	Molecular mechanism of suppression of MDR1 by puerarin from Pueraria lobata via NF-kappaB pathway and cAMP-responsive element transcriptional activity-dependent up-regulation of AMP-activated_protein_kinase in breast_cancer MCF-7 / adr cells .
26985919	0	puerarin	10,18	NMU	40,43	puerarin	NMU	MESH:C033607	10874	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effect of puerarin on the expression of NMU , NPY , and POMC genes in the hypothalamus .
24496955	0	puerarin	26,34	PKC	102,105	puerarin	PKC	MESH:C033607	29340(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY mediated|nsubjpass|effects mediated|nmod|END_ENTITY	The protective effects of puerarin in cardiomyocytes from anoxia/reoxygenation injury are mediated by PKC .
22027447	0	puerarin	11,19	Smad3	45,50	puerarin	Smad3	MESH:C033607	25631(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effects of puerarin on expression of cardiac Smad3 and Smad7 mRNA in spontaneously hypertensive rat .
19166018	0	puerarin	11,19	TGF-beta1	33,42	puerarin	TGF-beta1	MESH:C033607	59086(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|nmod|END_ENTITY	-LSB- Effect of puerarin on levels of TGF-beta1 and alpha-SMA in rats with alcoholic_injury_liver -RSB- .
18051529	0	puerarin	36,44	albumin	62,69	puerarin	albumin	MESH:C033607	213	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Studies on the interaction between puerarin and bovine serum albumin -RSB- .
16038632	4	puerarin	621,629	c-fos	633,638	puerarin	c-fos	MESH:C033607	314322(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	The aim of this study is to investigate the effect of puerarin on c-fos , c-jun and CoIV expression in GMC cultured in medium containing 5.6 or 27.8 mmol/L glucose .
18330247	0	puerarin	12,20	nuclear_factor_kappaB	38,59	puerarin	nuclear factor kappaB	MESH:C033607	309165(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of puerarin on expression of nuclear_factor_kappaB after cerebral_ischemia / reperfusion in rats -RSB- .
16677576	0	puerarin	12,20	thrombin	81,89	puerarin	thrombin	MESH:C033607	29251(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY induced|nsubj|Effects induced|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Effects of puerarin on proliferation of vascular smooth muscle cells induced by thrombin -RSB- .
20301656	0	purine	107,113	Adenosine_Deaminase	0,19	purine	Adenosine Deaminase	MESH:C030985	100	Chemical	Gene	metabolic_disorder|compound|START_ENTITY Adenosine_deaminase|acl:relcl|metabolic_disorder CHARACTERISTICS|dep|Adenosine_deaminase CHARACTERISTICS|compound|END_ENTITY	Adenosine_Deaminase Deficiency DISEASE CHARACTERISTICS : Adenosine_deaminase -LRB- ADA -RRB- deficiency is a systemic purine metabolic_disorder that primarily affects lymphocyte development , viability , and function .
25466177	0	purine	35,41	CB2	67,70	purine	CB2	MESH:C030985	1269	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	The SAR development of substituted purine derivatives as selective CB2 agonists for the treatment of chronic_pain .
22495427	0	purine	34,40	XDH	53,56	purine	XDH	MESH:C030985	7498	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|appos|END_ENTITY	Polymorphism of genes involved in purine metabolism -LRB- XDH , AOX1 , MOCOS -RRB- in kidney transplant recipients receiving azathioprine .
3367398	0	purine	86,92	adenosine_deaminase	51,70	purine	adenosine deaminase	MESH:C030985	24165(Tax:10116)	Chemical	Gene	compounds|amod|START_ENTITY inhibition|nmod|compounds characterization|dep|inhibition characterization|nmod|END_ENTITY	Purification and partial characterization of brain adenosine_deaminase : inhibition by purine compounds and by drugs .
5898336	0	purine	15,21	adenosine_deaminase	37,56	purine	adenosine deaminase	MESH:C030985	100	Chemical	Gene	Deamination|nmod|START_ENTITY antibiotics|nsubj|Deamination antibiotics|nmod|END_ENTITY	Deamination of purine antibiotics by adenosine_deaminase .
818021	0	purine	44,50	adenosine_deaminase	14,33	purine	adenosine deaminase	MESH:C030985	100070773(Tax:9796)	Chemical	Gene	enzymes|compound|START_ENTITY enzymes|compound|END_ENTITY	Evaluation of adenosine_deaminase and other purine salvage pathway enzymes in horses with combined_immunodeficiency .
9539871	0	purine	74,80	adenosine_deaminase	94,113	purine	adenosine deaminase	MESH:C030985	100346236(Tax:9986)	Chemical	Gene	metabolites|compound|START_ENTITY assess|nmod|metabolites microdialysis|acl|assess microdialysis|dep|inhibition inhibition|amod|END_ENTITY	Dual cardiac microdialysis to assess drug-induced changes in interstitial purine metabolites : adenosine_deaminase inhibition versus adenosine_kinase inhibition .
4672340	0	purine	110,116	adenosine_kinase	59,75	purine	adenosine kinase	MESH:C030985	132	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	On the existence of a guanine_nucleotide trap , the role of adenosine_kinase and a possible cause of excessive purine production in mammalian cells .
20570525	0	purine	19,25	c-Src_tyrosine_kinase	92,113	purine	c-Src tyrosine kinase	MESH:C030985	1445	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	Discovery of novel purine derivatives with potent and selective inhibitory activity against c-Src_tyrosine_kinase .
19475601	0	purine	74,80	caveolin_1	49,59	purine	caveolin 1	MESH:C030985	857	Chemical	Gene	complex|compound|START_ENTITY complex|amod|END_ENTITY	Novel extreme homozygote haplotypes at the human caveolin_1 gene upstream purine complex in sporadic Alzheimer 's _ disease .
22659071	0	purine	53,59	caveolin_1	28,38	purine	caveolin 1	MESH:C030985	857	Chemical	Gene	complex|compound|START_ENTITY complex|amod|END_ENTITY	Haplotypes across the human caveolin_1 gene upstream purine complex significantly alter gene expression : implication in neurodegenerative_disorders .
23640536	0	purine	66,72	caveolin_1	46,56	purine	caveolin 1	MESH:C030985	857	Chemical	Gene	complex|compound|START_ENTITY complex|amod|END_ENTITY	Biased homozygous haplotypes across the human caveolin_1 upstream purine complex in Parkinson 's _ disease .
12057661	0	purine_nucleosides	102,120	adenosine_deaminase	58,77	purine nucleosides	adenosine deaminase	MESH:D011684	100	Chemical	Gene	hydrolysis|nmod|START_ENTITY hydrolysis|amod|END_ENTITY	Is the anomeric effect an important factor in the rate of adenosine_deaminase catalyzed hydrolysis of purine_nucleosides ?
3031295	0	purine_nucleosides	47,65	adenosine_deaminase	88,107	purine nucleosides	adenosine deaminase	MESH:D011684	100	Chemical	Gene	START_ENTITY|nmod|action action|nmod|END_ENTITY	Resolution of racemic carbocyclic analogues of purine_nucleosides through the action of adenosine_deaminase .
19747168	0	purine_nucleotides	35,53	Uncoupling_protein_1	0,20	purine nucleotides	Uncoupling protein 1	MESH:D011685	24860(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Uncoupling_protein_1 inhibition by purine_nucleotides is under the control of the endogenous ubiquinone redox state .
8457591	0	purines	117,124	ACP1	108,112	purines	ACP1	MESH:D011687	52	Chemical	Gene	modulation|nmod|START_ENTITY modulation|appos|END_ENTITY	Activity modulation of the fast and slow isozymes of human cytosolic low-molecular-weight acid_phosphatase -LRB- ACP1 -RRB- by purines .
11756435	0	purines	66,73	DNA_polymerase_beta	8,27	purines	DNA polymerase beta	MESH:D011687	5423	Chemical	Gene	START_ENTITY|nsubj|Loss Loss|nmod|END_ENTITY	Loss of DNA_polymerase_beta stacking interactions with templating purines , but not pyrimidines , alters catalytic efficiency and fidelity .
31491	0	purines	27,34	HCN	0,3	purines	HCN	MESH:D011687	378938	Chemical	Gene	source|nmod|START_ENTITY END_ENTITY|dep|source	HCN : a plausible source of purines , pyrimidines and amino_acids on the primitive earth .
12191963	0	puromycin_aminonucleoside	77,102	NHE3	59,63	puromycin aminonucleoside	NHE3	MESH:D011692	24784(Tax:10116)	Chemical	Gene	rats|nmod|START_ENTITY END_ENTITY|nmod|rats	Regulation of the proximal tubular sodium/proton exchanger NHE3 in rats with puromycin_aminonucleoside -LRB- PAN -RRB- - induced nephrotic_syndrome .
24463119	0	puromycin_aminonucleoside	50,75	RANK-RANKL	21,31	puromycin aminonucleoside	RANK-RANKL	MESH:D011692	117516(Tax:10116)	Chemical	Gene	-RSB-|amod|START_ENTITY expression|nmod|-RSB- expression|nmod|END_ENTITY	-LSB- Renal expression of RANK-RANKL in a rat model of puromycin_aminonucleoside nephropathy -RSB- .
1415478	0	puromycin_aminonucleoside	48,73	ZO-1	154,158	puromycin aminonucleoside	ZO-1	MESH:D011692	292994(Tax:10116)	Chemical	Gene	nephrosis|amod|START_ENTITY seen|nmod|nephrosis slits|acl|seen contain|nsubj|slits contain|dobj|END_ENTITY	The altered glomerular filtration slits seen in puromycin_aminonucleoside nephrosis and protamine_sulfate-treated rats contain the tight junction protein ZO-1 .
15744817	0	puromycin_aminonucleoside	53,78	ZO-1	34,38	puromycin aminonucleoside	ZO-1	MESH:D011692	292994(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Impact of cyclosporin on podocyte ZO-1 expression in puromycin_aminonucleoside nephrosis rats .
10462268	0	puromycin_aminonucleoside	78,103	albumin	35,42	puromycin aminonucleoside	albumin	MESH:D011692	24186(Tax:10116)	Chemical	Gene	tissues|nmod|START_ENTITY END_ENTITY|nmod|tissues	In vivo microvascular clearance of albumin in renal and extrarenal tissues in puromycin_aminonucleoside -LRB- PAN -RRB- induced nephrotic_syndrome .
23498794	0	puromycin_aminonucleoside	45,70	bad	8,11	puromycin aminonucleoside	bad	MESH:D011692	572	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Role Role|nmod|END_ENTITY	Role of bad in podocyte apoptosis induced by puromycin_aminonucleoside .
24747598	0	puromycin_aminonucleoside	51,76	survivin	12,20	puromycin aminonucleoside	Survivin	MESH:D011692	11799(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|role role|nmod|END_ENTITY	The role of survivin in podocyte injury induced by puromycin_aminonucleoside .
2165054	0	purple_acid	35,46	uteroferrin	22,33	purple acid	uteroferrin	null	397414(Tax:9823)	Chemical	Gene	phosphatase|amod|START_ENTITY END_ENTITY|appos|phosphatase	Transfer of iron from uteroferrin -LRB- purple_acid phosphatase -RRB- to transferrin related to acid phosphatase activity .
8401327	0	putrescine	40,50	Ornithine_decarboxylase	0,23	putrescine	Ornithine decarboxylase	MESH:D011700	18263(Tax:10090)	Chemical	Gene	inactivation|nmod|START_ENTITY inactivation|amod|END_ENTITY	Ornithine_decarboxylase inactivation by putrescine : involvement of lipid peroxidation .
11583148	0	putrescine	108,118	S-adenosylmethionine_decarboxylase	21,55	putrescine	S-adenosylmethionine decarboxylase	MESH:D011700	262	Chemical	Gene	stimulation|amod|START_ENTITY intermediate|nmod|stimulation intermediate|amod|END_ENTITY	Structure of a human S-adenosylmethionine_decarboxylase self-processing ester intermediate and mechanism of putrescine stimulation of processing as revealed by the H243A mutant .
1415709	0	putrescine	10,20	S-adenosylmethionine_decarboxylase	24,58	putrescine	S-adenosylmethionine decarboxylase	MESH:D011700	81640(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of putrescine on S-adenosylmethionine_decarboxylase in a small intestinal crypt cell line .
19053272	0	putrescine	21,31	S-adenosylmethionine_decarboxylase	52,86	putrescine	S-adenosylmethionine decarboxylase	MESH:D011700	262	Chemical	Gene	activation|amod|START_ENTITY basis|nmod|activation basis|nmod|END_ENTITY	Structural basis for putrescine activation of human S-adenosylmethionine_decarboxylase .
9880821	0	putrescine	73,83	S-adenosylmethionine_decarboxylase	0,34	putrescine	S-adenosylmethionine decarboxylase	MESH:D011700	262	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	S-adenosylmethionine_decarboxylase activity and utilization of exogenous putrescine are enhanced in colon_cancer cells stimulated to grow by EGF .
1937393	0	putrescine	15,25	epidermal_growth_factor	40,63	putrescine	epidermal growth factor	MESH:D011700	25313(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Stimulation of putrescine production by epidermal_growth_factor in rat liver after partial hepatectomy .
2040654	0	putrescine	8,18	interleukin_1_beta	22,40	putrescine	interleukin 1 beta	MESH:D011700	3553	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|production production|amod|END_ENTITY	Role of putrescine in interleukin_1_beta production in human histiocytic_lymphoma cell line U937 .
1008888	0	putrescine	76,86	ornithine_decarboxylase	21,44	putrescine	ornithine decarboxylase	MESH:D011700	4953	Chemical	Gene	effect|nmod|START_ENTITY account|nmod|effect account|nsubj|inhibitor inhibitor|nmod|END_ENTITY	Protein inhibitor of ornithine_decarboxylase does not account for effect of putrescine on 3T3 cells .
1174509	0	putrescine	54,64	ornithine_decarboxylase	14,37	putrescine	ornithine decarboxylase	MESH:D011700	4953	Chemical	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	Regulation of ornithine_decarboxylase in 3T3 cells by putrescine and spermidine : indirect evidence for translational control .
1727906	0	putrescine	92,102	ornithine_decarboxylase	13,36	putrescine	ornithine decarboxylase	MESH:D011700	24609(Tax:10116)	Chemical	Gene	replacement|amod|START_ENTITY liver|nmod|replacement regenerating|dobj|liver Aging|advcl|regenerating Aging|dobj|END_ENTITY	Aging alters ornithine_decarboxylase and decreases polyamines in regenerating rat liver but putrescine replacement has no effect .
2051998	0	putrescine	57,67	ornithine_decarboxylase	30,53	putrescine	ornithine decarboxylase	MESH:D011700	4953	Chemical	Gene	induced|nmod|START_ENTITY induced|dobj|END_ENTITY	Modulation of insulin induced ornithine_decarboxylase by putrescine and methylputrescines in H-35 hepatoma cells .
2106270	0	putrescine	64,74	ornithine_decarboxylase	11,34	putrescine	ornithine decarboxylase	MESH:D011700	24609(Tax:10116)	Chemical	Gene	half-life|nmod|START_ENTITY END_ENTITY|dep|half-life	Intestinal ornithine_decarboxylase : half-life and regulation by putrescine .
3091594	0	putrescine	121,131	ornithine_decarboxylase	55,78	putrescine	ornithine decarboxylase	MESH:D011700	4953	Chemical	Gene	synthesis|compound|START_ENTITY END_ENTITY|nmod|synthesis	Spermidine N1-acetyltransferase has a larger role than ornithine_decarboxylase in 1 alpha,25-dihydroxyvitamin _ D3-induced putrescine synthesis .
3934184	0	putrescine	168,178	ornithine_decarboxylase	14,37	putrescine	ornithine decarboxylase	MESH:D011700	4953	Chemical	Gene	effects|appos|START_ENTITY comparison|nmod|effects Inhibition|dep|comparison Inhibition|nmod|activity activity|amod|END_ENTITY	Inhibition of ornithine_decarboxylase activity and cell growth by diamines : a comparison between the effects of two homologs , 1,3-diaminopropane and 1,4-diaminobutane -LRB- putrescine -RRB- .
3948865	0	putrescine	11,21	ornithine_decarboxylase	54,77	putrescine	ornithine decarboxylase	MESH:D011700	24609(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of putrescine on synthesis and degradation of ornithine_decarboxylase in primary cultured hepatocytes .
4721611	0	putrescine	79,89	ornithine_decarboxylase	11,34	putrescine	ornithine decarboxylase	MESH:D011700	4953	Chemical	Gene	Control|nmod|START_ENTITY Control|nmod|activity activity|amod|END_ENTITY	Control of ornithine_decarboxylase activity in stimulated human lymphocytes by putrescine and spermidine .
6114735	0	putrescine	73,83	ornithine_decarboxylase	34,57	putrescine	ornithine decarboxylase	MESH:D011700	4953	Chemical	Gene	modification|nmod|START_ENTITY modification|nmod|END_ENTITY	Posttranslational modification of ornithine_decarboxylase by its product putrescine .
8528457	0	putrescine	188,198	ornithine_decarboxylase	144,167	putrescine	ornithine decarboxylase	MESH:D011700	4953	Chemical	Gene	evidence|acl:relcl|START_ENTITY gene|dep|evidence gene|compound|END_ENTITY	Cerebral energy metabolism and immediate early gene induction following severe incomplete ischaemia in transgenic_mice overexpressing the human ornithine_decarboxylase gene : evidence that putrescine is not neurotoxic in vivo .
8845305	0	putrescine	59,69	ornithine_decarboxylase	98,121	putrescine	ornithine decarboxylase	MESH:D011700	4953	Chemical	Gene	death|amod|START_ENTITY death|nmod|cells cells|amod|END_ENTITY	Exposure to ornithine results in excessive accumulation of putrescine and apoptotic cell death in ornithine_decarboxylase overproducing mouse myeloma cells .
12871859	0	pyocyanin	34,43	catalase	53,61	pyocyanin	catalase	MESH:D011710	847	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	The Pseudomonas secretory product pyocyanin inhibits catalase activity in human lung epithelial cells .
9826354	0	pyocyanin	12,21	interleukin-8	32,45	pyocyanin	interleukin-8	MESH:D011710	3576	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Pseudomonas pyocyanin increases interleukin-8 expression by human airway epithelial cells .
22821204	0	pyoverdine	25,35	S11	127,130	pyoverdine	S11	MESH:C042453	6267	Chemical	Gene	START_ENTITY|nmod|colonization colonization|nmod|END_ENTITY	Influence of siderophore pyoverdine synthesis and iron-uptake on abiotic and biotic surface colonization of Pseudomonas putida S11 .
23392768	0	pyoverdine	49,59	S11	92,95	pyoverdine	S11	MESH:C042453	6267	Chemical	Gene	synthesis|amod|START_ENTITY synthesis|nmod|END_ENTITY	Influence of periplasmic oxidation of glucose on pyoverdine synthesis in Pseudomonas putida S11 .
17989320	0	pyranonaphthoquinones	41,62	AKT/PKB	102,109	pyranonaphthoquinones	AKT/PKB	null	207	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Discovery of lactoquinomycin and related pyranonaphthoquinones as potent and allosteric inhibitors of AKT/PKB : mechanistic involvement of AKT catalytic activation loop cysteines .
17048193	0	pyrazinamide	24,36	alpha-amino-beta-carboxymuconate-epsilon-semialdehyde_decarboxylase	86,153	pyrazinamide	alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase	MESH:D011718	171385(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Differential effects of pyrazinamide and clofibrate on gene expression of rat hepatic alpha-amino-beta-carboxymuconate-epsilon-semialdehyde_decarboxylase , a key enzyme of the tryptophan-NAD pathway .
16392826	0	pyrazine	51,59	B-RAF	20,25	pyrazine	B-RAF	CHEBI:30953	673	Chemical	Gene	based|nmod|START_ENTITY END_ENTITY|acl|based	Novel inhibitors of B-RAF based on a disubstituted pyrazine scaffold .
17513109	0	pyrazine_carboxamide	13,33	CB1	34,37	pyrazine carboxamide	CB1	MESH:D011718	25248(Tax:10116)	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|compound|END_ENTITY	Discovery of pyrazine_carboxamide CB1 antagonists : the introduction of a hydroxyl group improves the pharmaceutical properties and in vivo efficacy of the series .
15341931	0	pyrazinone	6,16	mast_cell_tryptase	31,49	pyrazinone	mast cell tryptase	null	25823	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|nmod|END_ENTITY	Novel pyrazinone inhibitors of mast_cell_tryptase : synthesis and SAR evaluation .
15890436	0	pyrazinone	6,16	thrombin	32,40	pyrazinone	thrombin	null	2147	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Novel pyrazinone and pyridinone thrombin inhibitors incorporating weakly basic heterobicyclic P -LRB- 1 -RRB- - arginine mimetics .
15686936	0	pyrazinone_mono-amides	6,28	caspase-3	54,63	pyrazinone mono-amides	caspase-3	null	836	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Novel pyrazinone_mono-amides as potent and reversible caspase-3 inhibitors .
9648274	0	pyrazole	70,78	CC-1065	110,117	pyrazole	CC-1065	MESH:C031280	940519(Tax:190650)	Chemical	Gene	analogs|compound|START_ENTITY analogs|nmod|END_ENTITY	Synthesis , cytotoxicity and antitumor activity of some new simplified pyrazole analogs of the antitumor agent CC-1065 .
12620660	0	pyrazole	210,218	COX-2	100,105	pyrazole	COX-2	MESH:C031280	4513	Chemical	Gene	ring|amod|START_ENTITY core|nmod|ring replacement|nmod|core activity|nmod|replacement effects|nmod|activity Synthesis|dep|effects Synthesis|dep|arylmethyloxy arylmethyloxy|dep|inhibitors inhibitors|compound|END_ENTITY	Synthesis of heteroaromatic analogues of -LRB- 2-aryl-1-cyclopentenyl-1-alkylidene -RRB- - -LRB- arylmethyloxy -RRB- amine COX-2 inhibitors : effects on the inhibitory activity of the replacement of the cyclopentene central core with pyrazole , thiophene or isoxazole ring .
21138530	0	pyrazole	24,32	COX-2	8,13	pyrazole	COX-2	MESH:C031280	24679512	Chemical	Gene	START_ENTITY|nsubj|inhibitor inhibitor|compound|END_ENTITY	A novel COX-2 inhibitor pyrazole derivative proven effective as an anti-inflammatory and analgesic drug .
22516672	0	pyrazole	65,73	COX-2	114,119	pyrazole	COX-2	MESH:C031280	26198(Tax:10116)	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|inhibitors inhibitors|compound|END_ENTITY	Synthesis , biological evaluation and molecular modeling study of pyrazole and pyrazoline derivatives as selective COX-2 inhibitors and anti-inflammatory agents .
18462938	0	pyrazole	11,19	EP1	20,23	pyrazole	EP1	MESH:C031280	5731	Chemical	Gene	START_ENTITY|dobj|antagonists antagonists|nummod|END_ENTITY	Non-acidic pyrazole EP1 receptor antagonists with in vivo analgesic efficacy .
172084	0	pyrazole	70,78	alcohol_dehydrogenase	12,33	pyrazole	alcohol dehydrogenase	MESH:C031280	10327	Chemical	Gene	activity|acl|START_ENTITY inhibition|nmod|activity END_ENTITY|dep|inhibition	Human liver alcohol_dehydrogenase -- inhibition of methanol activity by pyrazole , 4-methylpyrazole , 4-hydroxymethylpyrazole and 4-carboxypyrazole .
3036002	0	pyrazole	92,100	alcohol_dehydrogenase	60,81	pyrazole	alcohol dehydrogenase	MESH:C031280	10327	Chemical	Gene	START_ENTITY|nsubj|Production Production|nmod|4-hydroxypyrazole 4-hydroxypyrazole|nmod|interaction interaction|nmod|inhibitor inhibitor|amod|END_ENTITY	Production of 4-hydroxypyrazole from the interaction of the alcohol_dehydrogenase inhibitor pyrazole with hydroxyl radical .
3123698	0	pyrazole	71,79	alcohol_dehydrogenase	100,121	pyrazole	alcohol dehydrogenase	MESH:C031280	10327	Chemical	Gene	derivative|amod|START_ENTITY binding|nmod|derivative END_ENTITY|amod|binding	Comparison of computer modelling and X-ray results of the binding of a pyrazole derivative to liver alcohol_dehydrogenase .
515510	0	pyrazole	13,21	alcohol_dehydrogenase	39,60	pyrazole	alcohol dehydrogenase	MESH:C031280	78959(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Influence of pyrazole , an inhibitor of alcohol_dehydrogenase on the prenatal toxicity of ethanol in the rat .
7016530	0	pyrazole	16,24	alcohol_dehydrogenase	42,63	pyrazole	alcohol dehydrogenase	MESH:C031280	10327	Chemical	Gene	pH|nmod|START_ENTITY Effect|nmod|pH Effect|amod|binding binding|nmod|END_ENTITY	Effect of pH on pyrazole binding to liver alcohol_dehydrogenase .
7604387	0	pyrazole	84,92	alcohol_dehydrogenase	51,72	pyrazole	alcohol dehydrogenase	MESH:C031280	3771877(Tax:7227)	Chemical	Gene	properties|amod|START_ENTITY properties|nmod|inhibitors inhibitors|amod|END_ENTITY	Differences in teratogenic and toxic properties of alcohol_dehydrogenase inhibitors pyrazole and 4-methylpyrazole in Drosophila_melanogaster : I. ADH allozymes in variable genetic backgrounds .
7709366	0	pyrazole	84,92	alcohol_dehydrogenase	51,72	pyrazole	alcohol dehydrogenase	MESH:C031280	3771877(Tax:7227)	Chemical	Gene	properties|amod|START_ENTITY properties|nmod|inhibitors inhibitors|amod|END_ENTITY	Differences in teratogenic and toxic properties of alcohol_dehydrogenase inhibitors pyrazole and 4-methylpyrazole in Drosophila_melanogaster : II .
4151018	0	pyrazole	10,18	catalase	32,40	pyrazole	catalase	MESH:C031280	24248(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of pyrazole on rat liver catalase .
23664099	0	pyrazole-benzimidazole	82,104	Aurora_A	127,135	pyrazole-benzimidazole	Aurora A	null	6790	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Design , synthesis , quantum chemical studies and biological activity evaluation of pyrazole-benzimidazole derivatives as potent Aurora_A / B kinase inhibitors .
16843659	0	pyrazole_acid	24,37	EP1	58,61	pyrazole acid	EP1	null	25637(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	Identification of novel pyrazole_acid antagonists for the EP1 receptor .
18571922	0	pyrazole_amide	39,53	EP1	54,57	pyrazole amide	EP1	null	5731	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|compound|END_ENTITY	Discovery of brain penetrant , soluble , pyrazole_amide EP1 receptor antagonists .
15293263	0	pyrazoles	28,37	cyclooxygenase-2	51,67	pyrazoles	cyclooxygenase-2	MESH:D011720	5743	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	QSAR analysis of some fused pyrazoles as selective cyclooxygenase-2 inhibitors : a Hansch approach .
21434686	0	pyrazoles	73,82	cyclooxygenase-2	105,121	pyrazoles	cyclooxygenase-2	MESH:D011720	29527(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Synthesis and structure-activity relationship studies of urea-containing pyrazoles as dual inhibitors of cyclooxygenase-2 and soluble_epoxide_hydrolase .
20934334	0	pyrazoles	12,21	sEH	31,34	pyrazoles	sEH	MESH:D011720	2053	Chemical	Gene	START_ENTITY|nmod|antagonist antagonist|compound|END_ENTITY	Substituted pyrazoles as novel sEH antagonist : investigation of key binding interactions within the catalytic domain .
15713382	0	pyrazolidine	28,40	dipeptidyl_peptidase_IV	56,79	pyrazolidine	dipeptidyl peptidase IV	CHEBI:33138	1803	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Synthesis and evaluation of pyrazolidine derivatives as dipeptidyl_peptidase_IV -LRB- DP-IV -RRB- inhibitors .
18215030	0	pyrazolo-triazolo-pyrimidine	128,156	adenosine_A2A_receptor	195,217	pyrazolo-triazolo-pyrimidine	adenosine A2A receptor	MESH:C477655	135	Chemical	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Linear and nonlinear 3D-QSAR approaches in tandem with ligand-based homology modeling as a computational strategy to depict the pyrazolo-triazolo-pyrimidine antagonists binding site of the human adenosine_A2A_receptor .
15044055	0	pyrazolo_pyrimidine	6,25	cyclooxygenase-2	50,66	pyrazolo pyrimidine	cyclooxygenase-2	CHEBI:38669	19225(Tax:10090)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|nmod|END_ENTITY	A new pyrazolo_pyrimidine derivative inhibitor of cyclooxygenase-2 with anti-angiogenic activity .
14977851	0	pyrazoloacridine	18,34	p450_and_flavin_monooxygenase	63,92	pyrazoloacridine	p450 and flavin monooxygenase	MESH:C064541	1555	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|nmod|END_ENTITY	The metabolism of pyrazoloacridine -LRB- NSC_366140 -RRB- by cytochromes p450_and_flavin_monooxygenase in human liver microsomes .
24920381	0	pyrazolocurcuminoids	76,96	5-lipoxygenase	141,155	pyrazolocurcuminoids	5-lipoxygenase	null	11689(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	SAR studies on curcumin 's pro-inflammatory targets : discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase .
17174091	0	pyrazolopiperazinone	6,26	MCH-R1	58,64	pyrazolopiperazinone	MCH-R1	MESH:C518524	2847	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|compound|END_ENTITY	Novel pyrazolopiperazinone - and pyrrolopiperazinone-based MCH-R1 antagonists .
15739175	0	pyrazolopyridines	136,153	CDK2	116,120	pyrazolopyridines	CDK2	CHEBI:46699	1017	Chemical	Gene	affinities|nmod|START_ENTITY affinities|nmod|END_ENTITY	Insights from ab initio quantum chemical calculations into the preferred tautomeric forms and binding affinities to CDK2 of substituted pyrazolopyridines .
11297448	0	pyrazolopyridines	12,29	PDE5	54,58	pyrazolopyridines	PDE5	CHEBI:46699	8654	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Substituted pyrazolopyridines as potent and selective PDE5 inhibitors : potential agents for treatment of erectile_dysfunction .
24373283	0	pyrazolopyrimidine	40,58	B-Raf	87,92	pyrazolopyrimidine	B-Raf	CHEBI:38669	673	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Insight into the structural features of pyrazolopyrimidine - and pyrazolopyridine-based B-Raf -LRB- V600E -RRB- kinase inhibitors by computational explorations .
19896845	0	pyrazolopyrimidine	46,64	mTOR	65,69	pyrazolopyrimidine	mTOR	CHEBI:38669	21977(Tax:10090)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Incorporation of water-solubilizing groups in pyrazolopyrimidine mTOR inhibitors : discovery of highly potent and selective analogs with improved human microsomal stability .
19875283	0	pyrazolopyrimidines	6,25	B-Raf	43,48	pyrazolopyrimidines	B-Raf	CHEBI:38669	673	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Novel pyrazolopyrimidines as highly potent B-Raf inhibitors .
22342124	0	pyrazolopyrimidines	37,56	p70S6K	60,66	pyrazolopyrimidines	p70S6K	CHEBI:38669	6198	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Design and evaluation of a series of pyrazolopyrimidines as p70S6K inhibitors .
16913726	0	pyrazolopyrimidopyridazinones	6,35	PDE5	83,87	pyrazolopyrimidopyridazinones	PDE5	null	8654	Chemical	Gene	START_ENTITY|nmod|activity activity|appos|END_ENTITY	Novel pyrazolopyrimidopyridazinones with potent and selective phosphodiesterase_5 -LRB- PDE5 -RRB- inhibitory activity as potential agents for treatment of erectile_dysfunction .
16913726	0	pyrazolopyrimidopyridazinones	6,35	phosphodiesterase_5	62,81	pyrazolopyrimidopyridazinones	phosphodiesterase 5	null	8654	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Novel pyrazolopyrimidopyridazinones with potent and selective phosphodiesterase_5 -LRB- PDE5 -RRB- inhibitory activity as potential agents for treatment of erectile_dysfunction .
21835615	0	pyrazolyl_and_thienyl_aminohydantoins	4,41	BACE1	52,57	pyrazolyl and thienyl aminohydantoins	BACE1	null	23621	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	New pyrazolyl_and_thienyl_aminohydantoins as potent BACE1 inhibitors : exploring the S2 ' region .
21775139	0	pyrazolylpyrrole	20,36	ERK	52,55	pyrazolylpyrrole	ERK	null	5594	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Structure tuning of pyrazolylpyrrole derivatives as ERK inhibitors utilizing dual tools ; 3D-QSAR and side-chain hopping .
10756232	0	pyrene	28,34	IL-4	61,65	pyrene	IL-4	MESH:C030984	16189(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|nmod|END_ENTITY	The environmental pollutant pyrene induces the production of IL-4 .
12946434	0	pyrene	29,35	IL-8	58,62	pyrene	IL-8	MESH:C030984	3576	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	The diesel exhaust component pyrene induces expression of IL-8 but not of eotaxin .
23590426	0	pyrene	99,105	acetylcholinesterase	33,53	pyrene	acetylcholinesterase	MESH:C030984	43	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Real-time fluorometric assay for acetylcholinesterase activity and inhibitor screening through the pyrene probe monomer-excimer transition .
25196058	0	pyrenocine_B	21,33	EpsinR	0,6	pyrenocine B	EpsinR	MESH:C052580	9685	Chemical	Gene	target|nmod|START_ENTITY END_ENTITY|appos|target	EpsinR , a target for pyrenocine_B , role in endogenous MHC-II-restricted antigen presentation .
15120606	0	pyrenylalanine	45,59	CCK	103,106	pyrenylalanine	CCK	null	885	Chemical	Gene	synthesis|nmod|START_ENTITY synthesis|nmod|END_ENTITY	A novel 3-step enantioselective synthesis of pyrenylalanine with subsequent incorporation into opioid , CCK , and melanotropin ligands .
11082455	0	pyrethroid	96,106	brain-derived_neurotrophic_factor	43,76	pyrethroid	brain-derived neurotrophic factor	null	12064(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Repression of activity-dependent c-fos and brain-derived_neurotrophic_factor mRNA expression by pyrethroid insecticides accompanying a decrease in Ca -LRB- 2 + -RRB- influx into neurons .
23576335	0	pyrethroids	24,35	Ant	0,3	pyrethroids	Ant	MESH:D011722	293	Chemical	Gene	efficacy|nmod|START_ENTITY END_ENTITY|dobj|efficacy	Ant control efficacy of pyrethroids and fipronil on outdoor concrete surfaces .
7595515	0	pyrethroids	51,62	acetylcholinesterase	14,34	pyrethroids	acetylcholinesterase	MESH:D011722	83817(Tax:10116)	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|END_ENTITY	Modulation in acetylcholinesterase of rat brain by pyrethroids in vivo and an in vitro kinetic study .
8232282	0	pyrethroids	50,61	monoamine_oxidase-A	14,33	pyrethroids	monoamine oxidase-A	MESH:D011722	29253(Tax:10116)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of monoamine_oxidase-A of rat brain by pyrethroids -- an in vitro kinetic study .
21875806	0	pyridazine	41,51	EAAT2	89,94	pyridazine	EAAT2	MESH:C062482	6506	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Structure-activity relationship study of pyridazine derivatives as glutamate transporter EAAT2 activators .
24304424	0	pyridazinone	6,18	vascular_adhesion_protein-1	34,61	pyridazinone	vascular adhesion protein-1	CHEBI:26414	8639	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|nmod|END_ENTITY	Novel pyridazinone inhibitors for vascular_adhesion_protein-1 -LRB- VAP-1 -RRB- : old target-new inhibition mode .
19043245	0	pyridazinylacetic_acid	18,40	monoamine_oxidase-A	73,92	pyridazinylacetic acid	monoamine oxidase-A	null	4128	Chemical	Gene	START_ENTITY|nmod|class class|nmod|inhibitors inhibitors|amod|END_ENTITY	Synthesis of some pyridazinylacetic_acid derivatives as a novel class of monoamine_oxidase-A inhibitors .
21398122	0	pyridin-2-yloxymethylpiperidin-1-ylbutyl_amide	24,70	CCR5	71,75	pyridin-2-yloxymethylpiperidin-1-ylbutyl amide	CCR5	null	1234	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|compound|END_ENTITY	Design and synthesis of pyridin-2-yloxymethylpiperidin-1-ylbutyl_amide CCR5 antagonists that are potent inhibitors of M-tropic -LRB- R5 -RRB- HIV-1 replication .
19736007	0	pyridine	6,14	CB2	51,54	pyridine	CB2	MESH:C023666	57302(Tax:10116)	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	Novel pyridine derivatives as potent and selective CB2 cannabinoid receptor agonists .
12147272	0	pyridine	20,28	CYP1A1	0,6	pyridine	CYP1A1	MESH:C023666	1543	Chemical	Gene	induction|nmod|START_ENTITY induction|nsubj|END_ENTITY	CYP1A1 induction by pyridine and its metabolites in HepG2 cells .
20006497	0	pyridine	106,114	ROCK1	119,124	pyridine	ROCK1	MESH:C023666	6093	Chemical	Gene	START_ENTITY|nmod|selectivity selectivity|compound|END_ENTITY	2,3,5-Trisubstituted _ pyridines as selective AKT inhibitors-Part I : Substitution at 2-position of the core pyridine for ROCK1 selectivity .
3668864	0	pyridine	72,80	cytochrome_P-450	52,68	pyridine	cytochrome P-450	MESH:C023666	100328948(Tax:9986)	Chemical	Gene	microsomal|nmod|START_ENTITY microsomal|xcomp|END_ENTITY	Inhibition and induction of rabbit liver microsomal cytochrome_P-450 by pyridine .
7406903	0	pyridine	40,48	cytochrome_P-450	87,103	pyridine	cytochrome P-450	MESH:C023666	25251(Tax:10116)	Chemical	Gene	ability|nmod|START_ENTITY relationship|nmod|ability pyridines|nsubj|relationship pyridines|xcomp|maintain maintain|xcomp|END_ENTITY	The relationship between the ability of pyridine and substituted pyridines to maintain cytochrome_P-450 and inhibit protein synthesis in rat hepatocyte cultures .
886443	0	pyridine	11,19	cytochrome_P-450	35,51	pyridine	cytochrome P-450	MESH:C023666	4051	Chemical	Gene	derivatives|amod|START_ENTITY Binding|nmod|derivatives Binding|nmod|END_ENTITY	Binding of pyridine derivatives to cytochrome_P-450 .
8230122	0	pyridine	15,23	leukotriene_B4_receptor	24,47	pyridine	leukotriene B4 receptor	MESH:C023666	1241	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|amod|END_ENTITY	Trisubstituted pyridine leukotriene_B4_receptor antagonists : synthesis and structure-activity relationships .
12005500	0	pyridine-2-carboxamido	50,72	III	104,107	pyridine-2-carboxamido	III	null	4514	Chemical	Gene	complexes|amod|START_ENTITY complexes|appos|END_ENTITY	Unusual reactivity of methylene group adjacent to pyridine-2-carboxamido moiety in iron -LRB- III -RRB- and cobalt -LRB- III -RRB- complexes .
22000948	0	pyridine_acyl_sulfonamide	47,72	COX-2	94,99	pyridine acyl sulfonamide	COX-2	null	19225(Tax:10090)	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Design , synthesis and biological evaluation of pyridine_acyl_sulfonamide derivatives as novel COX-2 inhibitors .
17076898	0	pyridine_ether	73,87	PPAR	88,92	pyridine ether	PPAR	null	5465	Chemical	Gene	agonists|compound|START_ENTITY agonists|compound|END_ENTITY	ADDP and PS-PPh3 : an efficient Mitsunobu protocol for the preparation of pyridine_ether PPAR agonists .
7391953	0	pyridines	33,42	cytochrome_P-450	48,64	pyridines	cytochrome P-450	MESH:D011725	4051	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Ligand interaction of sustituted pyridines with cytochrome_P-450 .
7406903	0	pyridines	65,74	cytochrome_P-450	87,103	pyridines	cytochrome P-450	MESH:D011725	25251(Tax:10116)	Chemical	Gene	START_ENTITY|xcomp|maintain maintain|xcomp|END_ENTITY	The relationship between the ability of pyridine and substituted pyridines to maintain cytochrome_P-450 and inhibit protein synthesis in rat hepatocyte cultures .
12565962	0	pyridines	45,54	dopamine_transporter	64,84	pyridines	dopamine transporter	MESH:D011725	6531	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Pharmacophore-based discovery of substituted pyridines as novel dopamine_transporter inhibitors .
9873497	0	pyridines	31,40	endothelin_converting_enzyme-1	58,88	pyridines	endothelin converting enzyme-1	MESH:D011725	1889	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Synthesis of novel substituted pyridines as inhibitors of endothelin_converting_enzyme-1 -LRB- ECE-1 -RRB- .
8847965	0	pyridinium	101,111	CYP3A	59,64	pyridinium	CYP3A	null	170509(Tax:10116)	Chemical	Gene	production|nmod|START_ENTITY END_ENTITY|nmod|production	Studies on the metabolism of haloperidol -LRB- HP -RRB- : the role of CYP3A in the production of the neurotoxic pyridinium metabolite HPP + found in rat brain following ip administration of HP .
22712755	0	pyridinium	20,30	NTf2	14,18	pyridinium	NTf2	null	10204	Chemical	Gene	family|compound|START_ENTITY family|compound|END_ENTITY	Modeling the -LSB- NTf2 -RSB- pyridinium ionic liquids family and their mixtures with the soft statistical associating fluid theory equation of state .
26185800	0	pyridinium	80,90	uracil-DNA_glycosylase	37,59	pyridinium	uracil-DNA glycosylase	null	7374	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Sensitive and selective detection of uracil-DNA_glycosylase activity with a new pyridinium luminescent switch-on molecular probe .
9124047	0	pyridinoline	26,38	growth_hormone	52,66	pyridinoline	growth hormone	null	2688	Chemical	Gene	START_ENTITY|nmod|children children|amod|END_ENTITY	Rapid decrease of urinary pyridinoline excretion in growth_hormone deficient children following discontinuation of growth_hormone therapy .
9871547	0	pyridinone_acetamide	48,68	thrombin	69,77	pyridinone acetamide	thrombin	null	29251(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|inhibitor inhibitor|compound|END_ENTITY	L-374 ,087 , an efficacious , orally bioavailable , pyridinone_acetamide thrombin inhibitor .
2493243	0	pyridinones	32,43	tyrosinase	18,28	pyridinones	tyrosinase	MESH:D011728	7299	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	The inhibition of tyrosinase by pyridinones .
9827991	0	pyridinyl_imidazole	59,78	p38_MAP_kinase	93,107	pyridinyl imidazole	p38 MAP kinase	null	1432	Chemical	Gene	START_ENTITY|dobj|inhibitors inhibitors|nmod|END_ENTITY	A single amino_acid substitution makes ERK2 susceptible to pyridinyl_imidazole inhibitors of p38_MAP_kinase .
20481631	0	pyridinylimidazol-2-ones	69,93	p38alpha	110,118	pyridinylimidazol-2-ones	p38alpha	null	1432	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Unexpected reaction of 2-alkylsulfanylimidazoles to imidazol-2-ones : pyridinylimidazol-2-ones as novel potent p38alpha mitogen-activated protein kinase inhibitors .
23641780	0	pyridoquinazoline	48,65	epidermal_growth_factor_receptor	88,120	pyridoquinazoline	epidermal growth factor receptor	null	1956	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|inhibitors inhibitors|compound|END_ENTITY	Design , synthesis , and biological evaluation of pyridoquinazoline derivatives as potent epidermal_growth_factor_receptor inhibitors .
2229305	0	pyridostigmine	41,55	GH	25,27	pyridostigmine	GH	MESH:D011729	2688	Chemical	Gene	response|xcomp|START_ENTITY response|nsubj|growth_hormone growth_hormone|appos|END_ENTITY	Impaired growth_hormone -LRB- GH -RRB- response to pyridostigmine in type 1 diabetic patients with exaggerated GH-releasing_hormone-stimulated GH secretion .
10770183	0	pyridostigmine	126,140	GHRH	168,172	pyridostigmine	GHRH	MESH:D011729	2691	Chemical	Gene	hormone|compound|START_ENTITY hormone|appos|END_ENTITY	Diagnosis of growth_hormone _ -LRB- GH -RRB- _ deficiency in adults with hypothalamic-pituitary_disorders : comparison of test results using pyridostigmine plus GH-releasing hormone -LRB- GHRH -RRB- , clonidine plus GHRH , and insulin-induced hypoglycemia as GH secretagogues .
1358762	0	pyridostigmine	46,60	GHRH	83,87	pyridostigmine	GHRH	MESH:D011729	2691	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|response response|acl|END_ENTITY	Effect of potentiation of cholinergic tone by pyridostigmine on the GH response to GHRH in elderly men .
1934529	0	pyridostigmine	10,24	GHRH	60,64	pyridostigmine	GHRH	MESH:D011729	2691	Chemical	Gene	Effect|nmod|START_ENTITY Effect|acl|END_ENTITY	Effect of pyridostigmine and pirenzepine on GH responses to GHRH in hyperthyroid patients .
2220258	13	pyridostigmine	1271,1285	GHRH	1335,1339	pyridostigmine	GHRH	MESH:D011729	2691	Chemical	Gene	enhancement|nmod|START_ENTITY able|nsubj|enhancement able|xcomp|potentiate potentiate|xcomp|END_ENTITY	In conclusion , the cholinergic enhancement by pyridostigmine is able to potentiate the blunted GH response to GHRH in elderly subjects , inducing a GH increase similar to that observed after GHRH alone in young adults .
8872421	0	pyridostigmine	24,38	GHRH	61,65	pyridostigmine	GHRH	MESH:D011729	2691	Chemical	Gene	START_ENTITY|nmod|response response|nmod|END_ENTITY	The enhancing effect of pyridostigmine on the GH response to GHRH undergoes an accelerated age-related reduction_in_Down_syndrome .
9026681	0	pyridostigmine	107,121	GHRH	86,90	pyridostigmine	GHRH	MESH:D011729	2691	Chemical	Gene	-RSB-|amod|START_ENTITY combination|nmod|-RSB- combination|nmod|END_ENTITY	-LSB- Effect of sex on the increase of GH induced by galanin , alone or in combination with GHRH with or without pyridostigmine in pubescent subjects -RSB- .
9585379	0	pyridostigmine	47,61	GHRH	23,27	pyridostigmine	GHRH	MESH:D011729	2691	Chemical	Gene	sequential|amod|START_ENTITY sequential|amod|END_ENTITY	Plasma GH responses to GHRH , arginine , L-dopa , pyridostigmine , sequential administrations of GHRH and combined administration of PD and GHRH in Turner 's _ syndrome .
9585379	0	pyridostigmine	47,61	GHRH	93,97	pyridostigmine	GHRH	MESH:D011729	2691	Chemical	Gene	sequential|amod|START_ENTITY administrations|amod|sequential administrations|nmod|END_ENTITY	Plasma GH responses to GHRH , arginine , L-dopa , pyridostigmine , sequential administrations of GHRH and combined administration of PD and GHRH in Turner 's _ syndrome .
7833422	0	pyridostigmine	28,42	Growth_hormone	0,14	pyridostigmine	Growth hormone	MESH:D011729	2688	Chemical	Gene	responses|acl|START_ENTITY responses|amod|END_ENTITY	Growth_hormone responses to pyridostigmine in schizophrenia : evidence for cholinergic_dysfunction .
8406340	0	pyridostigmine	41,55	Growth_hormone	0,14	pyridostigmine	Growth hormone	MESH:D011729	2688	Chemical	Gene	response|nmod|START_ENTITY END_ENTITY|xcomp|response	Growth_hormone -LRB- GH -RRB- response to combined pyridostigmine and GH-releasing_hormone administration in patients with Prader-Labhard-Willi_syndrome .
10361382	0	pyridostigmine	11,25	TRH	71,74	pyridostigmine	TRH	MESH:D011729	7200	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|response response|nmod|END_ENTITY	Effects of pyridostigmine and naloxone on the abnormal TSH response to TRH during starvation in humans .
11131034	0	pyridostigmine	19,33	acetylcholinesterase	59,79	pyridostigmine	acetylcholinesterase	MESH:D011729	11423(Tax:10090)	Chemical	Gene	training|compound|START_ENTITY training|nmod|END_ENTITY	Delayed effects of pyridostigmine and exercise training on acetylcholinesterase and muscle_tension in mouse lower extremity .
11701190	0	pyridostigmine	24,38	acetylcholinesterase	86,106	pyridostigmine	acetylcholinesterase	MESH:D011729	83817(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY stress|nsubj|effects stress|dobj|performance performance|compound|END_ENTITY	The combined effects of pyridostigmine and chronic stress on brain cortical and blood acetylcholinesterase , corticosterone , prolactin and alternation performance in rats .
11829412	0	pyridostigmine	25,39	acetylcholinesterase	75,95	pyridostigmine	acetylcholinesterase	MESH:D011729	100422792	Chemical	Gene	administration|compound|START_ENTITY effect|nmod|administration END_ENTITY|nsubj|effect	The effect of continuous pyridostigmine administration on functional -LRB- A12 -RRB- acetylcholinesterase activity in guinea-pig muscles .
1895153	0	pyridostigmine	80,94	acetylcholinesterase	35,55	pyridostigmine	acetylcholinesterase	MESH:D011729	43	Chemical	Gene	START_ENTITY|nsubj|Determination Determination|nmod|activity activity|compound|END_ENTITY	Determination of erythrocyte-bound acetylcholinesterase activity for monitoring pyridostigmine therapy in myasthenia_gravis .
21981462	0	pyridostigmine	113,127	acetylcholinesterase	73,93	pyridostigmine	acetylcholinesterase	MESH:D011729	11423(Tax:10090)	Chemical	Gene	comparison|nmod|START_ENTITY comparison|nmod|END_ENTITY	A comparison of the efficacy of newly developed reversible inhibitors of acetylcholinesterase with commonly used pyridostigmine as pharmacological pre-treatment of soman-poisoned mice .
9023571	0	pyridostigmine	11,25	acetylcholinesterase	29,49	pyridostigmine	acetylcholinesterase	MESH:D011729	11423(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of pyridostigmine on acetylcholinesterase in different muscles of the mouse .
9088969	0	pyridostigmine	34,48	acetylcholinesterase	52,72	pyridostigmine	acetylcholinesterase	MESH:D011729	11423(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of repeated treatment with pyridostigmine on acetylcholinesterase in mouse muscles .
10770183	0	pyridostigmine	126,140	growth_hormone	13,27	pyridostigmine	growth hormone	MESH:D011729	2688	Chemical	Gene	hormone|compound|START_ENTITY using|dobj|hormone results|acl|using comparison|nmod|results hypothalamic-pituitary_disorders|dep|comparison _|nmod|hypothalamic-pituitary_disorders _|nsubj|Diagnosis Diagnosis|nmod|_ _|amod|END_ENTITY	Diagnosis of growth_hormone _ -LRB- GH -RRB- _ deficiency in adults with hypothalamic-pituitary_disorders : comparison of test results using pyridostigmine plus GH-releasing hormone -LRB- GHRH -RRB- , clonidine plus GHRH , and insulin-induced hypoglycemia as GH secretagogues .
11782869	0	pyridostigmine	15,29	growth_hormone	90,104	pyridostigmine	growth hormone	MESH:D011729	2688	Chemical	Gene	stimulation|amod|START_ENTITY use|nmod|stimulation test|nsubj|use test|xcomp|detect detect|dobj|deficiency deficiency|amod|END_ENTITY	The use of the pyridostigmine growth_hormone-releasing hormone stimulation test to detect growth_hormone deficiency in patients with pituitary_adenomas .
12445839	0	pyridostigmine	80,94	growth_hormone	53,67	pyridostigmine	growth hormone	MESH:D011729	2688	Chemical	Gene	Effects|acl|START_ENTITY Effects|nmod|therapy therapy|nmod|response response|amod|END_ENTITY	Effects of long-term estrogen replacement therapy on growth_hormone response to pyridostigmine in healthy postmenopausal women .
1407375	0	pyridostigmine	26,40	growth_hormone	98,112	pyridostigmine	growth hormone	MESH:D011729	2688	Chemical	Gene	potentiation|amod|START_ENTITY Effects|nmod|potentiation Effects|nmod|release release|compound|END_ENTITY	Effects of sex and age on pyridostigmine potentiation of growth_hormone-releasing hormone-induced growth_hormone release .
1483293	0	pyridostigmine	97,111	growth_hormone	9,23	pyridostigmine	growth hormone	MESH:D011729	2688	Chemical	Gene	enhanced|nmod|START_ENTITY enhanced|nsubjpass|rise rise|compound|END_ENTITY	The late growth_hormone rise induced by oral glucose is enhanced by cholinergic stimulation with pyridostigmine in normal subjects .
1543015	0	pyridostigmine	34,48	growth_hormone	163,177	pyridostigmine	growth hormone	MESH:D011729	2688	Chemical	Gene	tone|nmod|START_ENTITY Activation|nmod|tone reverses|nsubj|Activation reverses|nmod|secretion secretion|compound|END_ENTITY	Activation of cholinergic tone by pyridostigmine reverses the inhibitory effect of corticotropin-releasing_hormone on the growth_hormone-releasing_hormone-induced growth_hormone secretion .
1592867	0	pyridostigmine	13,27	growth_hormone	31,45	pyridostigmine	growth hormone	MESH:D011729	2688	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|response response|amod|END_ENTITY	Influence of pyridostigmine on growth_hormone -LRB- GH -RRB- response to GH-releasing_hormone pre - and postprandially in normal and obese subjects .
1618997	0	pyridostigmine	58,72	growth_hormone	31,45	pyridostigmine	growth hormone	MESH:D011729	2688	Chemical	Gene	steroid|advcl|START_ENTITY steroid|nmod|response response|amod|END_ENTITY	Sex steroid priming effects on growth_hormone response to pyridostigmine throughout the menstrual cycle .
17407215	0	pyridostigmine	44,58	growth_hormone	185,199	pyridostigmine	growth hormone	MESH:D011729	2688	Chemical	Gene	exercise|amod|START_ENTITY treatment|nmod|exercise months|nmod|treatment combination|nmod|months fails|nsubj|combination fails|xcomp|improve improve|nmod|improvement improvement|nmod|response response|amod|END_ENTITY	A combination of 6 months of treatment with pyridostigmine and triweekly exercise fails to improve insulin-like_growth_factor-I levels in fibromyalgia , despite improvement in the acute growth_hormone response to exercise .
1758382	0	pyridostigmine	30,44	growth_hormone	67,81	pyridostigmine	growth hormone	MESH:D011729	2688	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|stimulation stimulation|nmod|END_ENTITY	-LSB- Effect of pre-treatment with pyridostigmine on the stimulation of growth_hormone by clonidine and GRF -RSB- .
1769130	0	pyridostigmine	11,25	growth_hormone	89,103	pyridostigmine	growth hormone	MESH:D011729	2688	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of pyridostigmine on spontaneous and growth_hormone-releasing_hormone stimulated growth_hormone secretion in children on daily glucocorticoid therapy after liver transplantation .
1874023	0	pyridostigmine	15,29	growth_hormone	47,61	pyridostigmine	growth hormone	MESH:D011729	2688	Chemical	Gene	Application|nmod|START_ENTITY Application|nmod|reserves reserves|amod|END_ENTITY	Application of pyridostigmine in evaluation of growth_hormone reserves in children and adolescents .
1960380	0	pyridostigmine	61,75	growth_hormone	34,48	pyridostigmine	growth hormone	MESH:D011729	2688	Chemical	Gene	differences|acl|START_ENTITY differences|nmod|response response|amod|END_ENTITY	Gender and age differences in the growth_hormone response to pyridostigmine .
2045624	0	pyridostigmine	31,45	growth_hormone	4,18	pyridostigmine	growth hormone	MESH:D011729	2688	Chemical	Gene	response|acl|START_ENTITY response|amod|END_ENTITY	The growth_hormone response to pyridostigmine plus growth_hormone_releasing_hormone is not influenced by pubertal maturation .
2105328	0	pyridostigmine	58,72	growth_hormone	111,125	pyridostigmine	growth hormone	MESH:D011729	2688	Chemical	Gene	START_ENTITY|nmod|relationships relationships|nmod|END_ENTITY	Effect of enhancement of endogenous cholinergic tone with pyridostigmine on the dose-response relationships of growth_hormone -LRB- GH -RRB- - releasing hormone-induced GH secretion in normal subjects .
2115060	0	pyridostigmine	122,136	growth_hormone	32,46	pyridostigmine	growth hormone	MESH:D011729	2688	Chemical	Gene	administration|nmod|START_ENTITY test|dep|administration test|nmod|diagnosis diagnosis|nmod|deficiency deficiency|amod|END_ENTITY	A new test for the diagnosis of growth_hormone deficiency due to primary pituitary_impairment : combined administration of pyridostigmine and growth_hormone-releasing_hormone .
2229305	0	pyridostigmine	41,55	growth_hormone	9,23	pyridostigmine	growth hormone	MESH:D011729	2688	Chemical	Gene	response|xcomp|START_ENTITY response|nsubj|END_ENTITY	Impaired growth_hormone -LRB- GH -RRB- response to pyridostigmine in type 1 diabetic patients with exaggerated GH-releasing_hormone-stimulated GH secretion .
2493023	0	pyridostigmine	35,49	growth_hormone	59,73	pyridostigmine	growth hormone	MESH:D011729	2688	Chemical	Gene	activation|nmod|START_ENTITY restores|nsubj|activation restores|dobj|responsiveness responsiveness|amod|END_ENTITY	Cholinergic receptor activation by pyridostigmine restores growth_hormone -LRB- GH -RRB- responsiveness to GH-releasing hormone administration in obese subjects : evidence for hypothalamic_somatostatinergic_participation in the blunted GH release of obesity .
2500577	0	pyridostigmine	37,51	growth_hormone	55,69	pyridostigmine	growth hormone	MESH:D011729	2688	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|amod|END_ENTITY	Effect of cholinergic enhancement by pyridostigmine on growth_hormone secretion in obese adults and children .
2566942	0	pyridostigmine	47,61	growth_hormone	113,127	pyridostigmine	growth hormone	MESH:D011729	2688	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nsubj|effect effect|nmod|END_ENTITY	Activation of cholinergic neurotransmission by pyridostigmine reverses the inhibitory effect of hyperglycemia on growth_hormone -LRB- GH -RRB- releasing hormone-induced GH secretion in man : does acute hyperglycemia act through hypothalamic release of somatostatin ?
7629249	0	pyridostigmine	90,104	growth_hormone	21,35	pyridostigmine	growth hormone	MESH:D011729	2688	Chemical	Gene	potentiates|nmod|START_ENTITY potentiates|dobj|response response|amod|END_ENTITY	Acipimox potentiates growth_hormone -LRB- GH -RRB- response to GH-releasing hormone with or without pyridostigmine by lowering serum free fatty_acid in normal and obese subjects .
7907904	0	pyridostigmine	21,35	growth_hormone	39,53	pyridostigmine	growth hormone	MESH:D011729	2688	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|response response|amod|END_ENTITY	Different effects of pyridostigmine on growth_hormone -LRB- GH -RRB- response to GH-releasing_hormone in endogenous and exogenous hypercortisolemic patients .
7927192	0	pyridostigmine	10,24	growth_hormone	80,94	pyridostigmine	growth hormone	MESH:D011729	2688	Chemical	Gene	START_ENTITY|nmod|decrease decrease|acl|circulating circulating|dobj|levels levels|amod|END_ENTITY	Effect of pyridostigmine on the hydrocortisone-mediated decrease of circulating growth_hormone levels in acromegaly .
8028515	0	pyridostigmine	10,24	growth_hormone	32,46	pyridostigmine	growth hormone	MESH:D011729	2688	Chemical	Gene	START_ENTITY|nmod|response response|amod|END_ENTITY	Effect of pyridostigmine on the growth_hormone response to growth_hormone-releasing hormone in lean and obese type II Diabetic patients .
8494078	0	pyridostigmine	37,51	growth_hormone	9,23	pyridostigmine	growth hormone	MESH:D011729	2688	Chemical	Gene	responses|acl|START_ENTITY responses|compound|END_ENTITY	Elevated growth_hormone responses to pyridostigmine in obsessive-compulsive_disorder : evidence of cholinergic supersensitivity .
9347094	0	pyridostigmine	10,24	thyrotropin-releasing_hormone	72,101	pyridostigmine	thyrotropin-releasing hormone	MESH:D011729	7200	Chemical	Gene	Effect|nmod|START_ENTITY Effect|acl|END_ENTITY	Effect of pyridostigmine on the thyroid-stimulating_hormone response to thyrotropin-releasing_hormone in abstinent alcoholics .
9440477	0	pyridostigmine	21,35	thyrotropin-releasing_hormone	67,96	pyridostigmine	thyrotropin-releasing hormone	MESH:D011729	7200	Chemical	Gene	effects|nmod|START_ENTITY effects|acl|END_ENTITY	Different effects of pyridostigmine on the thyrotropin response to thyrotropin-releasing_hormone in endogenous_depression and subclinical thyrotoxicosis .
2184685	0	pyridostigmine_bromide	32,54	Acetylcholinesterase	0,20	pyridostigmine bromide	Acetylcholinesterase	MESH:D011729	43	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Acetylcholinesterase inhibitor , pyridostigmine_bromide , reduces skin blood flow in humans .
14751452	0	pyridostigmine_bromide	15,37	acetylcholinesterase	116,136	pyridostigmine bromide	acetylcholinesterase	MESH:D011729	83817(Tax:10116)	Chemical	Gene	permethrin|amod|START_ENTITY Co-exposure|nmod|permethrin causes|nsubj|Co-exposure causes|dobj|deficit deficit|nmod|activity activity|compound|END_ENTITY	Co-exposure to pyridostigmine_bromide , DEET , and/or permethrin causes sensorimotor deficit and alterations in brain acetylcholinesterase activity .
20144889	0	pyridostigmine_bromide	14,36	acetylcholinesterase	64,84	pyridostigmine bromide	acetylcholinesterase	MESH:D011729	43	Chemical	Gene	Protection|nmod|START_ENTITY END_ENTITY|nsubj|Protection	Protection by pyridostigmine_bromide of marmoset hemi-diaphragm acetylcholinesterase activity after soman exposure .
6845436	0	pyridoxal-5-phosphate	29,50	albumin	68,75	pyridoxal-5-phosphate	albumin	MESH:D011732	213	Chemical	Gene	-RSB-|amod|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Mechanism of interaction of pyridoxal-5-phosphate with human serum albumin -RSB- .
4665286	0	pyridoxal_phosphate	11,30	DOPA_decarboxylase	64,82	pyridoxal phosphate	DOPA decarboxylase	MESH:D011732	1644	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|compound|END_ENTITY	Effects of pyridoxal_phosphate and L-dopapyridoxal_phosphate on DOPA_decarboxylase activity .
12021103	0	pyridoxal_phosphate	25,44	GAD65	63,68	pyridoxal phosphate	GAD65	MESH:D011732	2572	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	The PEVKEK region of the pyridoxal_phosphate binding domain of GAD65 expresses a dominant B cell epitope for type 1 diabetes sera .
2416896	0	pyridoxine	10,20	cytosolic_aspartate_aminotransferase	56,92	pyridoxine	cytosolic aspartate aminotransferase	MESH:D011736	24401(Tax:10116)	Chemical	Gene	administration|amod|START_ENTITY Effect|nmod|administration Effect|nmod|END_ENTITY	Effect of pyridoxine administration on the induction of cytosolic_aspartate_aminotransferase in the liver of rats treated with hydrocortisone .
263321	0	pyridoxine	10,20	growth_hormone	45,59	pyridoxine	growth hormone	MESH:D011736	2688	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|release release|nmod|END_ENTITY	Effect of pyridoxine on pituitary release of growth_hormone and prolactin in childhood and adolescence .
1243433	0	pyridoxine	33,43	prolactin	76,85	pyridoxine	prolactin	MESH:D011736	5617	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	-LSB- Effect of methergine , oxytocin , pyridoxine -LRB- vitamin_B_6 -RRB- and quinestrol on prolactin and milk secretion in puerperium -RSB- .
653534	0	pyridoxine	11,21	prolactin	47,56	pyridoxine	prolactin	MESH:D011736	5617	Chemical	Gene	Failure|nmod|START_ENTITY raised|nsubj|Failure raised|dobj|levels levels|compound|END_ENTITY	Failure of pyridoxine to suppress raised serum prolactin levels .
755053	0	pyridoxine	22,32	prolactin	43,52	pyridoxine	prolactin	MESH:D011736	5617	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of intravenous pyridoxine on plasma prolactin in hyperprolactinemic subjects .
6103702	0	pyridoxine	64,74	tyrosine_aminotransferase	27,52	pyridoxine	tyrosine aminotransferase	MESH:D011736	24813(Tax:10116)	Chemical	Gene	administration|amod|START_ENTITY END_ENTITY|nmod|administration	Stabilization of rat liver tyrosine_aminotransferase in vivo by pyridoxine administration .
21546249	0	pyridyl	27,34	mGluR5	7,13	pyridyl	mGluR5	null	14805(Tax:10090)	Chemical	Gene	antagonists|dep|START_ENTITY antagonists|amod|END_ENTITY	Potent mGluR5 antagonists : pyridyl and thiazolyl-ethynyl-3 ,5 - disubstituted-phenyl series .
12873950	0	pyrilamine	15,25	C-fos	49,54	pyrilamine	C-fos	MESH:D011738	314322(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nsubj|effects	The effects of pyrilamine and cimetidine on mRNA C-fos expression and nociceptive flinching behavior in rats .
21265544	0	pyrimethamine	56,69	b-hexosaminidase_B	21,39	pyrimethamine	b-hexosaminidase B	MESH:D011739	3074	Chemical	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Crystal structure of b-hexosaminidase_B in complex with pyrimethamine , a potential pharmacological chaperone .
25948633	0	pyrimidine	46,56	EGFR	0,4	pyrimidine	EGFR	MESH:C030986	1956	Chemical	Gene	START_ENTITY|nsubj|mutations mutations|compound|END_ENTITY	EGFR mutations and resistance to Irreversible pyrimidine based EGFR inhibitors .
23642479	0	pyrimidine	15,25	cdc2-like	44,53	pyrimidine	cdc2-like	MESH:C030986	1195	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|nmod|END_ENTITY	Small-molecule pyrimidine inhibitors of the cdc2-like -LRB- Clk -RRB- and dual_specificity_tyrosine_phosphorylation-regulated -LRB- Dyrk -RRB- kinases : development of chemical probe ML315 .
22246285	0	pyrimidine	27,37	checkpoint_kinase_1	111,130	pyrimidine	checkpoint kinase 1	MESH:C030986	1111	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Structural requirements of pyrimidine , thienopyridine and ureido_thiophene_carboxamide-based inhibitors of the checkpoint_kinase_1 : QSAR , docking , molecular dynamics analysis .
9873520	0	pyrimidine	72,82	factor_Xa	83,92	pyrimidine	factor Xa	MESH:C030986	2159	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Design , synthesis , and biological activity of novel purine and bicyclic pyrimidine factor_Xa inhibitors .
10455109	0	pyrimidine	58,68	hCNT1	160,165	pyrimidine	hCNT1	MESH:C030986	9154	Chemical	Gene	specificities|amod|START_ENTITY responsible|nmod|specificities residues|amod|responsible Identification|nmod|residues nucleoside|nsubj|Identification nucleoside|dobj|END_ENTITY	Identification of amino_acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na -LRB- + -RRB- _ nucleoside cotransporters hCNT1 and hCNT2 .
19272774	0	pyrimidine	25,35	phosphodiesterase_7	50,69	pyrimidine	phosphodiesterase 7	MESH:C030986	5150	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|nmod|END_ENTITY	Identification of potent pyrimidine inhibitors of phosphodiesterase_7 -LRB- PDE7 -RRB- and their ability to inhibit T cell proliferation .
24939104	0	pyrimidine-4-yl-ethanol	43,66	ROS1	82,86	pyrimidine-4-yl-ethanol	ROS1	null	6098	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Synthesis and biological evaluation of new pyrimidine-4-yl-ethanol derivatives as ROS1 kinase inhibitors .
24974342	0	pyrimidine-5-carbonitrile-6-alkyl	45,78	CXCR2	79,84	pyrimidine-5-carbonitrile-6-alkyl	CXCR2	null	3579	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|amod|END_ENTITY	The discovery of potent , orally bioavailable pyrimidine-5-carbonitrile-6-alkyl CXCR2 receptor antagonists .
18793846	0	pyrimidine_benzimidazoles	13,38	Lck	42,45	pyrimidine benzimidazoles	Lck	null	3932	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Discovery of pyrimidine_benzimidazoles as Lck inhibitors : part I .
21493064	0	pyrimidine_carboxamides	13,36	CCK1	61,65	pyrimidine carboxamides	CCK1	CHEBI:48438	56477	Chemical	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	Discovery of pyrimidine_carboxamides as potent and selective CCK1 receptor agonists .
225551	0	pyrimidine_deoxyribonucleoside	20,50	thymidine_kinase	59,75	pyrimidine deoxyribonucleoside	thymidine kinase	CHEBI:68472	24271467	Chemical	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	Characterization of pyrimidine_deoxyribonucleoside kinase -LRB- thymidine_kinase -RRB- and thymidylate kinase as a multifunctional enzyme in cells transformed by herpes_simplex_virus_type_1 and in cells infected with mutant strains of herpes_simplex_virus .
8700147	5	pyrimidine_nucleosides	634,656	rCNT1	603,608	pyrimidine nucleosides	rCNT1	MESH:D011741	116642(Tax:10116)	Chemical	Gene	transports|dobj|START_ENTITY transports|nsubj|END_ENTITY	Recombinant rCNT1 transports physiological pyrimidine_nucleosides and adenosine .
21420869	0	pyrimidine_nucleosides	12,34	ribonuclease_A	52,66	pyrimidine nucleosides	ribonuclease A	MESH:D011741	6035	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	5 ' - Modified pyrimidine_nucleosides as inhibitors of ribonuclease_A .
20453889	0	pyrimidine_nucleotide	14,35	PNC1	45,49	pyrimidine nucleotide	PNC1	CHEBI:26441	84275	Chemical	Gene	carrier|compound|START_ENTITY carrier|appos|END_ENTITY	Mitochondrial pyrimidine_nucleotide carrier -LRB- PNC1 -RRB- regulates mitochondrial biogenesis and the invasive phenotype of cancer cells .
21777202	0	pyrimidine_nucleotide	8,29	Rim2	0,4	pyrimidine nucleotide	Rim2	CHEBI:26441	852491(Tax:4932)	Chemical	Gene	exchanger|amod|START_ENTITY END_ENTITY|appos|exchanger	Rim2 , a pyrimidine_nucleotide exchanger , is needed for iron utilization in mitochondria .
19596576	0	pyrimidines	12,23	CB1	39,42	pyrimidines	CB1	MESH:D011743	1268	Chemical	Gene	START_ENTITY|nmod|ligands ligands|compound|END_ENTITY	Substituted pyrimidines as cannabinoid CB1 receptor ligands .
7815092	2	pyrimidines	146,157	dihydrofolate_reductase	119,142	pyrimidines	dihydrofolate reductase	MESH:D011743	13906554	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	The inhibition of dihydrofolate_reductase by pyrimidines .
17887745	0	pyrimidinylbenzoates	60,80	acetohydroxyacid_synthase	84,109	pyrimidinylbenzoates	acetohydroxyacid synthase	null	10994	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Rational design based on bioactive conformation analysis of pyrimidinylbenzoates as acetohydroxyacid_synthase inhibitors by integrating molecular docking , CoMFA , CoMSIA , and DFT calculations .
19785436	0	pyrimido-pyrrolo-quinoxalinedione	18,51	CFTR	52,56	pyrimido-pyrrolo-quinoxalinedione	CFTR	null	1080	Chemical	Gene	inhibitor|compound|START_ENTITY inhibitor|compound|END_ENTITY	Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst size in a polycystic_kidney_disease model .
19827834	0	pyrimidylpyrrole	48,64	extracellular_signal-regulated_kinase	79,116	pyrimidylpyrrole	extracellular signal-regulated kinase	null	5594	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|nmod|END_ENTITY	Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular_signal-regulated_kinase -LRB- ERK -RRB- using conformational control .
11498534	0	pyrin	20,25	ASC	59,62	pyrin	ASC	null	29108	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|appos|END_ENTITY	Interaction between pyrin and the apoptotic speck protein -LRB- ASC -RRB- modulates ASC-induced apoptosis .
23726149	0	pyrocarbon	90,100	Pi2	101,104	pyrocarbon	Pi2	MESH:C009139	1992	Chemical	Gene	-RSB-|amod|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Total trapeziectomy and suspension ligamentoplasty : is there any interest to interpose a pyrocarbon Pi2 implant ? -RSB- .
3015304	0	pyrogen	21,28	haptoglobin	128,139	pyrogen	haptoglobin	null	24464(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of endogenous pyrogen , corticosteroids and inhibitors of prostaglandins and leukotrienes on the plasma concentrations of haptoglobin and fibrinogen in rats .
1681074	0	pyrogens	9,17	interleukin-6	21,34	pyrogens	interleukin-6	MESH:D011749	3569	Chemical	Gene	START_ENTITY|nmod|release release|amod|END_ENTITY	Assay of pyrogens by interleukin-6 release from monocytic cell lines .
20211600	0	pyroglutamate	41,54	SLC5A8	74,80	pyroglutamate	SLC5A8	MESH:D011761	160728	Chemical	Gene	transport|nmod|START_ENTITY transport|nmod|END_ENTITY	Sodium-coupled electrogenic transport of pyroglutamate -LRB- 5-oxoproline -RRB- via SLC5A8 , a monocarboxylate transporter .
17035026	0	pyroglutamic_acid	21,38	thyrotropin-releasing_hormone	65,94	pyroglutamic acid	thyrotropin-releasing hormone	MESH:D011761	7200	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Modifications of the pyroglutamic_acid and histidine residues in thyrotropin-releasing_hormone -LRB- TRH -RRB- yield analogs with selectivity for TRH receptor type 2 over type 1 .
17762177	0	pyrophosphate	35,48	ANK	62,65	pyrophosphate	ANK	MESH:C107241	11732(Tax:10090)	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Expression and localisation of the pyrophosphate transporter , ANK , in murine kidney cells .
18034874	0	pyrophosphate	10,23	ANK	95,98	pyrophosphate	ANK	MESH:C107241	286	Chemical	Gene	generation|compound|START_ENTITY dependent|nsubj|generation dependent|nmod|END_ENTITY	Inorganic pyrophosphate generation by transforming_growth_factor-beta-1 is mainly dependent on ANK induction by Ras/Raf -1 / extracellular_signal-regulated_kinase pathways in chondrocytes .
15818664	0	pyrophosphate	216,229	ANKH	154,158	pyrophosphate	ANKH	MESH:C107241	56172	Chemical	Gene	protein|nmod|START_ENTITY protein|compound|END_ENTITY	Association of sporadic_chondrocalcinosis with a -4 - basepair G-to-A transition in the 5 ' - untranslated region of ANKH that promotes enhanced expression of ANKH protein and excess generation of extracellular inorganic pyrophosphate .
17067391	0	pyrophosphate	70,83	Ank	16,19	pyrophosphate	Ank	MESH:C107241	56172	Chemical	Gene	START_ENTITY|nsubj|mutation mutation|nmod|results results|compound|END_ENTITY	P5L mutation in Ank results in an increase in extracellular inorganic pyrophosphate during proliferation and nonmineralizing hypertrophy in stably transduced ATDC5 cells .
15039209	0	pyrophosphate	34,47	akp2	67,71	pyrophosphate	akp2	MESH:C107241	11647(Tax:10090)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Concerted regulation of inorganic pyrophosphate and osteopontin by akp2 , enpp1 , and ank : an integrated model of the pathogenesis of mineralization disorders .
2843563	0	pyrophosphate	14,27	myosin	47,53	pyrophosphate	myosin	MESH:C107241	79784	Chemical	Gene	START_ENTITY|nmod|reaction reaction|nmod|END_ENTITY	The effect of pyrophosphate on the reaction of myosin with 2,4,6-trinitrobenzene _ sulphonate .
10513816	0	pyrophosphate	37,50	plasma_cell_membrane_glycoprotein-1	65,100	pyrophosphate	plasma cell membrane glycoprotein-1	MESH:C107241	5167	Chemical	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Differential mechanisms of inorganic pyrophosphate production by plasma_cell_membrane_glycoprotein-1 and B10 in chondrocytes .
4352460	0	pyrophosphate	28,41	thrombin	97,105	pyrophosphate	thrombin	MESH:C107241	2147	Chemical	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of inorganic pyrophosphate in human platelets and its release on stimulation with thrombin .
18034874	0	pyrophosphate	10,23	transforming_growth_factor-beta-1	38,71	pyrophosphate	transforming growth factor-beta-1	MESH:C107241	7040	Chemical	Gene	generation|compound|START_ENTITY generation|nmod|END_ENTITY	Inorganic pyrophosphate generation by transforming_growth_factor-beta-1 is mainly dependent on ANK induction by Ras/Raf -1 / extracellular_signal-regulated_kinase pathways in chondrocytes .
19555187	0	pyrostatins_A_and_B	4,23	N-acetyl-beta-D-glucosaminidase	39,70	pyrostatins A and B	N-acetyl-beta-D-glucosaminidase	null	10724	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|END_ENTITY	The pyrostatins_A_and_B do not inhibit N-acetyl-beta-D-glucosaminidase .
20621728	0	pyrrole	40,47	MEK	63,66	pyrrole	MEK	CHEBI:19203	5609	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Structure-based design and synthesis of pyrrole derivatives as MEK inhibitors .
24463557	0	pyrrole-imidazole_polyamide	24,51	ABCA1	62,67	pyrrole-imidazole polyamide	ABCA1	null	11303(Tax:10090)	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	A novel gene regulator , pyrrole-imidazole_polyamide targeting ABCA1 gene increases cholesterol efflux from macrophages and plasma HDL concentration .
23969530	0	pyrrole-imidazole_polyamide	28,55	MMP-9	14,19	pyrrole-imidazole polyamide	MMP-9	null	4318	Chemical	Gene	using|dobj|START_ENTITY END_ENTITY|acl|using	Inhibition of MMP-9 using a pyrrole-imidazole_polyamide reduces cell invasion in renal_cell_carcinoma .
12056891	0	pyrrole-imidazole_polyamides	45,73	NF-kappa_B	29,39	pyrrole-imidazole polyamides	NF-kappa B	null	4790	Chemical	Gene	binding|nmod|START_ENTITY binding|nmod|END_ENTITY	Inhibition of DNA binding by NF-kappa_B with pyrrole-imidazole_polyamides .
25882525	0	pyrrole_carboxamide	6,25	JAK2	40,44	pyrrole carboxamide	JAK2	CHEBI:48611	3717	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|nmod|END_ENTITY	Novel pyrrole_carboxamide inhibitors of JAK2 as potential treatment of myeloproliferative_disorders .
18023580	0	pyrrolidine	7,18	BACE-1	41,47	pyrrolidine	BACE-1	MESH:C032519	23621	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Potent pyrrolidine - and piperidine-based BACE-1 inhibitors .
26620718	0	pyrrolidine	56,67	Mcl-1	83,88	pyrrolidine	Mcl-1	MESH:C032519	4170	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Design , synthesis and preliminary biological studies of pyrrolidine derivatives as Mcl-1 inhibitors .
20737212	0	pyrrolidine	28,39	dipeptidyl_peptidase_IV	53,76	pyrrolidine	dipeptidyl peptidase IV	MESH:C032519	1803	Chemical	Gene	analogues|compound|START_ENTITY analogues|nmod|inhibitors inhibitors|amod|END_ENTITY	CoMFA and CoMSIA of diverse pyrrolidine analogues as dipeptidyl_peptidase_IV inhibitors : active site requirements .
21299434	0	pyrrolidine	62,73	dipeptidyl_peptidase_IV	86,109	pyrrolidine	dipeptidyl peptidase IV	MESH:C032519	1803	Chemical	Gene	analogs|amod|START_ENTITY analogs|nmod|END_ENTITY	Development of a robust QSAR model to predict the affinity of pyrrolidine analogs for dipeptidyl_peptidase_IV -LRB- DPP - _ IV -RRB- .
21414780	0	pyrrolidine	6,17	hERG	84,88	pyrrolidine	hERG	MESH:C032519	2078	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|compound|END_ENTITY	Novel pyrrolidine melanin-concentrating_hormone_receptor_1 antagonists with reduced hERG inhibition .
7752184	0	pyrrolidine	8,19	histamine_H3_receptor	70,91	pyrrolidine	histamine H3 receptor	MESH:C032519	11255	Chemical	Gene	START_ENTITY|nmod|agonist agonist|amod|END_ENTITY	A novel pyrrolidine analog of histamine as a potent , highly selective histamine_H3_receptor agonist .
22251826	0	pyrrolidine	38,49	neuraminidase	72,85	pyrrolidine	neuraminidase	MESH:C032519	4758	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Docking and 3D-QSAR investigations of pyrrolidine derivatives as potent neuraminidase inhibitors .
20363126	0	pyrrolidine_carboxamide	27,50	11beta-HSD1	51,62	pyrrolidine carboxamide	11beta-HSD1	CHEBI:46770	3290	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	The development and SAR of pyrrolidine_carboxamide 11beta-HSD1 inhibitors .
15033443	0	pyrrolidine_dithiocarbamate	127,154	Sp1	21,24	pyrrolidine dithiocarbamate	Sp1	MESH:C020972	6667	Chemical	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Transcription factor Sp1 mediates p38MAPK-dependent activation of the p21WAF1 gene promoter in vascular smooth muscle cells by pyrrolidine_dithiocarbamate .
23433149	0	pyrrolidine_dithiocarbamate	17,44	connective_tissue_growth_factor	63,94	pyrrolidine dithiocarbamate	connective tissue growth factor	MESH:C020972	64032(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expressions expressions|nmod|END_ENTITY	-LSB- Intervention of pyrrolidine_dithiocarbamate on expressions of connective_tissue_growth_factor , type I collagen , and type_III_collage in acute paraquat poisoned rats -RSB- .
12453435	0	pyrrolidine_dithiocarbamate	29,56	cyclooxygenase-2	92,108	pyrrolidine dithiocarbamate	cyclooxygenase-2	MESH:C020972	19225(Tax:10090)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	The oxygen radical scavenger pyrrolidine_dithiocarbamate enhances interleukin-1beta-induced cyclooxygenase-2 expression in cerebral microvascular smooth muscle cells .
9837857	0	pyrrolidine_dithiocarbamate	59,86	heme_oxygenase_1	34,50	pyrrolidine dithiocarbamate	heme oxygenase 1	MESH:C020972	24451(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|gene gene|amod|END_ENTITY	Transcriptional regulation of the heme_oxygenase_1 gene by pyrrolidine_dithiocarbamate .
18474243	0	pyrrolidine_dithiocarbamate	67,94	hepatocyte_growth_factor	34,58	pyrrolidine dithiocarbamate	hepatocyte growth factor	MESH:C020972	3082	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|gene gene|compound|END_ENTITY	Transcriptional regulation of the hepatocyte_growth_factor gene by pyrrolidine_dithiocarbamate .
19856104	0	pyrrolidine_dithiocarbamate	91,118	nuclear_factor_kappa_B	14,36	pyrrolidine dithiocarbamate	nuclear factor kappa B	MESH:C020972	4790	Chemical	Gene	effect|nmod|START_ENTITY drives|dobj|effect drives|nsubj|Inhibition Inhibition|nmod|activity activity|amod|END_ENTITY	Inhibition of nuclear_factor_kappa_B transcription activity drives a synergistic effect of pyrrolidine_dithiocarbamate and cisplatin for treatment of renal_cell_carcinoma .
19882112	0	pyrrolidine_dithiocarbamate	27,54	nuclear_factor_kappa_B	58,80	pyrrolidine dithiocarbamate	nuclear factor kappa B	MESH:C020972	4790	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Anti-angiogenic actions of pyrrolidine_dithiocarbamate , a nuclear_factor_kappa_B inhibitor .
25177164	0	pyrrolidine_dithiocarbamate	59,86	nuclear_factor_kappa_B	26,48	pyrrolidine dithiocarbamate	nuclear factor kappa B	MESH:C020972	81736(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Protective effects of the nuclear_factor_kappa_B inhibitor pyrrolidine_dithiocarbamate on experimental testicular_torsion and detorsion injury .
24952131	0	pyrrolidine_dithiocarbamate	38,65	prolactin	15,24	pyrrolidine dithiocarbamate	prolactin	MESH:C020972	5617	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Suppression of prolactin signaling by pyrrolidine_dithiocarbamate is alleviated by N-acetylcysteine in mammary epithelial cells .
22529688	6	pyrrolidinedithiocarbamate	1492,1518	PDTC	1520,1524	pyrrolidinedithiocarbamate	bFGF	MESH:C020972	2247	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|appos|END_ENTITY	Interestingly , application of the NF-kB specific inhibitor , pyrrolidinedithiocarbamate -LRB- PDTC -RRB- , to SGC-7901 cells significantly potentized the toxicarioside_A-induced down-regulation of bFGF compared with the control group -LRB- P < 0.05 -RRB- .
2884061	0	pyrrolidonyl	39,51	aminopeptidase	52,66	pyrrolidonyl	aminopeptidase	null	10404	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Rapid identification of enterococci by pyrrolidonyl aminopeptidase activity -LRB- PYRase -RRB- .
24502590	0	pyrroline-5-carboxylate	34,57	ALDH4A1	73,80	pyrroline-5-carboxylate	ALDH4A1	MESH:C015485	8659	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	Structural studies of yeast -LRB- 1 -RRB- - pyrroline-5-carboxylate dehydrogenase -LRB- ALDH4A1 -RRB- : active site flexibility and oligomeric state .
21739576	0	pyrroline-5-carboxylate	98,121	P5CS	132,136	pyrroline-5-carboxylate	P5CS	MESH:C015485	5832	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	Further expansion of the phenotypic spectrum associated with mutations in ALDH18A1 , encoding / \ - pyrroline-5-carboxylate synthase -LRB- P5CS -RRB- .
19815412	0	pyrrolopyridazine	39,56	HER-2	78,83	pyrrolopyridazine	HER-2	MESH:C508945	2064	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Synthesis and biological evaluation of pyrrolopyridazine derivatives as novel HER-2 tyrosine kinase inhibitors .
23933111	0	pyrrolopyridinone	6,23	Cdc7	69,73	pyrrolopyridinone	Cdc7	null	8317	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|inhibitors inhibitors|nmod|END_ENTITY	Novel pyrrolopyridinone derivatives as anticancer inhibitors towards Cdc7 : QSAR studies based on dockings by solvation score approach .
18201066	0	pyrrolopyridinones	24,42	Cdc7	0,4	pyrrolopyridinones	Cdc7	null	8317	Chemical	Gene	inhibitors|dep|START_ENTITY inhibitors|amod|END_ENTITY	Cdc7 kinase inhibitors : pyrrolopyridinones as potential antitumor agents .
19115845	0	pyrrolopyridinones	30,48	Cdc7	6,10	pyrrolopyridinones	Cdc7	null	8317	Chemical	Gene	inhibitors|dep|START_ENTITY inhibitors|amod|END_ENTITY	First Cdc7 kinase inhibitors : pyrrolopyridinones as potent and orally active antitumor agents .
17502141	0	pyrrolopyrimidine	66,83	DPP-4	84,89	pyrrolopyrimidine	DPP-4	MESH:C527741	1803	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Modeling assisted rational design of novel , potent , and selective pyrrolopyrimidine DPP-4 inhibitors .
20178314	1	pyrrolopyrimidine	112,129	FAK	145,148	pyrrolopyrimidine	FAK	MESH:C527741	5747	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|nmod|END_ENTITY	Impact on the relative affinities of competing pyrrolopyrimidine inhibitors for FAK kinase .
20337583	0	pyrrolopyrimidine	48,65	cathepsin_K	20,31	pyrrolopyrimidine	cathepsin K	MESH:C527741	1513	Chemical	Gene	inhibitors|nmod|START_ENTITY inhibitors|compound|END_ENTITY	Orally bioavailable cathepsin_K inhibitors with pyrrolopyrimidine scaffold .
11738619	0	pyrrolopyrimidines	44,62	CRHR1	0,5	pyrrolopyrimidines	CRHR1	CHEBI:38670	1394	Chemical	Gene	Receptor|nmod|START_ENTITY Receptor|compound|END_ENTITY	CRHR1 Receptor binding and lipophilicity of pyrrolopyrimidines , potential nonpeptide corticotropin-releasing_hormone_type_1_receptor antagonists .
16168641	0	pyrrolopyrimidines	68,86	MRP1	40,44	pyrrolopyrimidines	MRP1	CHEBI:38670	4363	Chemical	Gene	activity|nmod|START_ENTITY activity|nummod|END_ENTITY	Topological model for the prediction of MRP1 inhibitory activity of pyrrolopyrimidines and templates derived from pyrrolopyrimidine .
14998323	0	pyrrolopyrimidines	11,29	multidrug-resistance-associated_protein	57,96	pyrrolopyrimidines	multidrug-resistance-associated protein	CHEBI:38670	8714	Chemical	Gene	Studies|nmod|START_ENTITY Studies|nmod|END_ENTITY	Studies on pyrrolopyrimidines as selective inhibitors of multidrug-resistance-associated_protein in multidrug resistance .
26622336	0	pyrroloquinoline_quinone	22,46	Bmi-1	66,71	pyrroloquinoline quinone	Bmi-1	MESH:D045542	12151(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|mice mice|compound|END_ENTITY	Biological effects of pyrroloquinoline_quinone on liver_damage in Bmi-1 knockout mice .
26708114	0	pyrrolospirooxindole	13,33	cyclin_dependent_kinase_4	55,80	pyrrolospirooxindole	cyclin dependent kinase 4	null	1019	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Discovery of pyrrolospirooxindole derivatives as novel cyclin_dependent_kinase_4 -LRB- CDK4 -RRB- inhibitors by catalyst-free , green approach .
20223661	0	pyrrolyl_2-aminopyridines	6,31	beta-secretase	62,76	pyrrolyl 2-aminopyridines	beta-secretase	null	23621	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Novel pyrrolyl_2-aminopyridines as potent and selective human beta-secretase -LRB- BACE1 -RRB- inhibitors .
35457	0	pyruvate	66,74	D-lactate_dehydrogenase	41,64	pyruvate	D-lactate dehydrogenase	MESH:D019289	197257	Chemical	Gene	kinase|amod|START_ENTITY kinase|amod|END_ENTITY	The effects of season and temperature on D-lactate_dehydrogenase , pyruvate kinase and arginine kinase in the foot of Helix pomatia L .
1378399	0	pyruvate	48,56	DNase-I	0,7	pyruvate	DNase-I	MESH:D019289	25633(Tax:10116)	Chemical	Gene	analysis|nmod|START_ENTITY analysis|amod|END_ENTITY	DNase-I hypersensitivity analysis of the L-type pyruvate kinase gene in rats and transgenic_mice .
20160912	1	pyruvate	118,126	E1	231,233	pyruvate	BP	MESH:D019289	50865	Chemical	Gene	consists|compound|START_ENTITY consists|dep|dehydrogenase dehydrogenase|appos|END_ENTITY	The human -LRB- h -RRB- pyruvate dehydrogenase complex -LRB- hPDC -RRB- consists of multiple copies of several components : pyruvate dehydrogenase -LRB- E1 -RRB- , dihydrolipoamide acetyltransferase -LRB- E2 -RRB- , dihydrolipoamide dehydrogenase -LRB- E3 -RRB- , E3-binding protein -LRB- BP -RRB- , and specific kinases and phosphatases .
20160912	1	pyruvate	207,215	E1	231,233	pyruvate	BP	MESH:D019289	50865	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	The human -LRB- h -RRB- pyruvate dehydrogenase complex -LRB- hPDC -RRB- consists of multiple copies of several components : pyruvate dehydrogenase -LRB- E1 -RRB- , dihydrolipoamide acetyltransferase -LRB- E2 -RRB- , dihydrolipoamide dehydrogenase -LRB- E3 -RRB- , E3-binding protein -LRB- BP -RRB- , and specific kinases and phosphatases .
11724561	0	pyruvate	103,111	E1beta	85,91	pyruvate	E1beta	MESH:D019289	594	Chemical	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	3D structure and significance of the GPhiXXG helix packing motif in tetramers of the E1beta subunit of pyruvate dehydrogenase from the archeon Pyrobaculum_aerophilum .
12650930	0	pyruvate	38,46	HERC1	20,25	pyruvate	HERC1	MESH:D019289	8925	Chemical	Gene	START_ENTITY|nsubj|Interaction Interaction|nmod|END_ENTITY	Interaction between HERC1 and M2-type pyruvate kinase .
12784616	0	pyruvate	16,24	JEN1	40,44	pyruvate	JEN1	MESH:D019289	853663(Tax:4932)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Analysis of the pyruvate permease gene -LRB- JEN1 -RRB- in glucose derepression yeast -LRB- Saccharomyces_cerevisiae -RRB- Isolated from a 2-deoxyglucose-tolerant mutant , and its application to sake making .
17517371	0	pyruvate	68,76	L-lactate_oxidase	45,62	pyruvate	L-lactate oxidase	MESH:D019289	4015	Chemical	Gene	study|nmod|START_ENTITY study|nmod|interaction interaction|nmod|END_ENTITY	Crystallographic study on the interaction of L-lactate_oxidase with pyruvate at 1.9 Angstrom resolution .
1282029	0	pyruvate	130,138	PDC-E2	162,168	pyruvate	PDC-E2	MESH:D019289	1737	Chemical	Gene	complex|amod|START_ENTITY complex|appos|END_ENTITY	Differing epitope selection of experimentally-induced and natural antibodies to a disease-specific autoantigen , the E2 subunit of pyruvate dehydrogenase complex -LRB- PDC-E2 -RRB- .
15113568	6	pyruvate	934,942	PDC2	978,982	pyruvate	pdc2	MESH:D019289	851654(Tax:4932)	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	The reduction of pyruvate decarboxylase activity by deleting PDC2 led to an additional increase .
3378452	0	pyruvate	21,29	PKL	38,41	pyruvate	PKL	MESH:D019289	5313	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The human liver-type pyruvate kinase -LRB- PKL -RRB- gene is on chromosome 1 at band q21 .
18759866	0	pyruvate	54,62	PKLR	41,45	pyruvate	PKLR	MESH:D019289	5313	Chemical	Gene	patients|amod|START_ENTITY gene|nmod|patients gene|compound|END_ENTITY	Spectrum of novel mutations in the human PKLR gene in pyruvate kinase-deficient Indian patients with heterogeneous clinical phenotypes .
19085939	0	pyruvate	48,56	PKLR	27,31	pyruvate	PKLR	MESH:D019289	5313	Chemical	Gene	deficiency|amod|START_ENTITY associated|nmod|deficiency END_ENTITY|acl|associated	Fifteen novel mutations in PKLR associated with pyruvate kinase -LRB- PK -RRB- deficiency : structural implications of amino_acid substitutions in PK .
24969675	0	pyruvate	37,45	PKLR	59,63	pyruvate	PKLR	MESH:D019289	5313	Chemical	Gene	kinase|amod|START_ENTITY gene|amod|kinase gene|appos|END_ENTITY	A previously unknown mutation in the pyruvate kinase gene -LRB- PKLR -RRB- identified from a neonate with severe jaundice .
9608355	0	pyruvate	78,86	PKLR	95,99	pyruvate	PKLR	MESH:D019289	5313	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	Structure and linkage relationships of the region containing the human L-type pyruvate kinase -LRB- PKLR -RRB- and glucocerebrosidase -LRB- GBA -RRB- genes .
9677056	0	pyruvate	90,98	PKLR	107,111	pyruvate	PKLR	MESH:D019289	5313	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Linkage disequilibrium of common Gaucher_disease mutations with a polymorphic site in the pyruvate kinase -LRB- PKLR -RRB- gene .
18298799	0	pyruvate	22,30	PML	66,69	pyruvate	PML	MESH:D019289	5371	Chemical	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	Modulation of M2-type pyruvate kinase activity by the cytoplasmic PML tumor suppressor protein .
16132722	0	pyruvate	80,88	Pkm2	97,101	pyruvate	Pkm2	MESH:D019289	25630(Tax:10116)	Chemical	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	High glucose upregulates pantothenate_kinase_4 -LRB- PanK4 -RRB- and thus affects M2-type pyruvate kinase -LRB- Pkm2 -RRB- .
9139918	0	pyruvate	40,48	Pyk2p	57,62	pyruvate	Pyk2p	MESH:D019289	854529(Tax:4932)	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	Characterization of a glucose-repressed pyruvate kinase -LRB- Pyk2p -RRB- in Saccharomyces_cerevisiae that is catalytically insensitive to fructose-1 ,6 - bisphosphate .
3593302	0	pyruvate	18,26	R-PK	38,42	pyruvate	R-PK	MESH:D019289	5313	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	Human erythrocyte pyruvate kinase -LRB- L' / R-PK -RRB- : production and characterization of a monoclonal antibody .
6546383	0	pyruvate	41,49	aldolase_B	19,29	pyruvate	aldolase B	MESH:D019289	24190(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|control control|nmod|END_ENTITY	Dietary control of aldolase_B and L-type pyruvate kinase mRNAs in rat .
3949360	0	pyruvate	48,56	glucose-6-phosphate_dehydrogenase	13,46	pyruvate	glucose-6-phosphate dehydrogenase	MESH:D019289	2539	Chemical	Gene	kinase|amod|START_ENTITY kinase|amod|END_ENTITY	Frequency of glucose-6-phosphate_dehydrogenase , pyruvate kinase and hexokinase deficiency in the Saudi population .
20654332	0	pyruvate	10,18	glutathione_s-transferase	22,47	pyruvate	glutathione s-transferase	MESH:D019289	58962(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of pyruvate on glutathione_s-transferase expression in primary cultures of rat hepatocytes .
3054434	0	pyruvate	29,37	growth_hormone	11,25	pyruvate	growth hormone	MESH:D019289	81668(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY END_ENTITY|nmod|activity	Effects of growth_hormone on pyruvate dehydrogenase activity in intact rat liver and in isolated hepatocytes : comparison with insulin .
736715	0	pyruvate	78,86	insulin	60,67	pyruvate	insulin	MESH:D019289	280829(Tax:9913)	Chemical	Gene	fatty_acids|dep|START_ENTITY fatty_acids|dep|END_ENTITY	-LSB- Behavior of various blood constituents -LRB- glucose , fructose , insulin , lactate , pyruvate , free fatty_acids , inorganic phosphate -RRB- and half-life of monosaccharides in the plasma after i.v. infusion of glucose , _ fructose , _ galactose and invert sugar solutions in ruminants .
736716	0	pyruvate	78,86	insulin	60,67	pyruvate	insulin	MESH:D019289	280829(Tax:9913)	Chemical	Gene	fatty_acids|dep|START_ENTITY fatty_acids|dep|END_ENTITY	-LSB- Behavior of various blood constituents -LRB- glucose , fructose , insulin , lactate , pyruvate , free fatty_acids , inorganic phosphate -RRB- and half-life of monosaccharides in the plasma after i.v. infusion of glucose , fructose , galactose and invert sugar solutions in ruminants .
736717	0	pyruvate	78,86	insulin	60,67	pyruvate	insulin	MESH:D019289	105613195	Chemical	Gene	fatty_acids|dep|START_ENTITY fatty_acids|dep|END_ENTITY	-LSB- Behavior of various blood constituents -LRB- glucose , fructose , insulin , lactate , pyruvate , free fatty_acids , inorganic phosphate -RRB- and the half-life of monosaccharides in plasma after i.v infusion of glucose , fructose , galactose and invert sugar solutions in ruminants .
1644204	0	pyruvate	109,117	kinase_activator_protein	78,102	pyruvate	kinase activator protein	MESH:D019289	24937(Tax:10116)	Chemical	Gene	kinase|compound|START_ENTITY END_ENTITY|appos|kinase	Purification and partial characterization of rat liver pyruvate dehydrogenase kinase_activator_protein -LRB- free pyruvate dehydrogenase kinase -RRB- .
9786900	0	pyruvate	62,70	monocarboxylate_transporter_2	6,35	pyruvate	monocarboxylate transporter 2	MESH:D019289	9194	Chemical	Gene	transporter|amod|START_ENTITY transporter|nsubj|END_ENTITY	Human monocarboxylate_transporter_2 -LRB- MCT2 -RRB- is a high affinity pyruvate transporter .
2719694	0	pyruvate	51,59	protein_X	8,17	pyruvate	protein X	MESH:D019289	5967	Chemical	Gene	function|nmod|START_ENTITY END_ENTITY|nmod|function	Role of protein_X in the function of the mammalian pyruvate dehydrogenase complex .
23576436	0	pyruvate	74,82	protein_kinase	25,39	pyruvate	protein kinase	MESH:D019289	1022	Chemical	Gene	activities|nmod|START_ENTITY activities|amod|END_ENTITY	Reciprocal regulation of protein_kinase and pyruvate kinase activities of pyruvate kinase M2 by growth signals .
4725035	0	pyruvate	14,22	pyruvate_carboxylase	38,58	pyruvate	pyruvate carboxylase	MESH:D019289	25104(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY Regulation|nmod|metabolism Regulation|nmod|END_ENTITY	Regulation of pyruvate metabolism via pyruvate_carboxylase in rat brain mitochondria .
10683263	0	pyruvate	31,39	regulatory_protein	100,118	pyruvate	regulatory protein	MESH:D019289	100273320(Tax:4577)	Chemical	Gene	START_ENTITY|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Further analysis of maize C -LRB- 4 -RRB- pyruvate , orthophosphate dikinase phosphorylation by its bifunctional regulatory_protein using selective substitutions of the regulatory Thr-456 and catalytic His-458 residues .
8069629	0	pyruvate	102,110	transketolase	87,100	pyruvate	transketolase	MESH:D019289	7086	Chemical	Gene	oxidase|amod|START_ENTITY oxidase|amod|END_ENTITY	A thiamin_diphosphate binding fold revealed by comparison of the crystal structures of transketolase , pyruvate oxidase and pyruvate decarboxylase .
20693722	0	qinghuobaiduyin	11,26	high_mobility_group_box_chromosomal_protein_1	48,93	qinghuobaiduyin	high mobility group box chromosomal protein 1	null	25459(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of qinghuobaiduyin on the expression of high_mobility_group_box_chromosomal_protein_1 in macrophage -RSB- .
12237812	0	quercetin	10,19	ACE	73,76	quercetin	ACE	MESH:D011794	24310(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of quercetin on plasma extravasation in rat CNS and dura mater by ACE and NEP inhibition .
17184768	0	quercetin	31,40	C-protein	139,148	quercetin	C-protein	MESH:D011794	1401	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	The anti-inflammatory flavones quercetin and kaempferol cause inhibition of inducible_nitric_oxide_synthase , cyclooxygenase-2 and reactive C-protein , and down-regulation of the nuclear factor kappaB pathway in Chang Liver cells .
17111826	0	quercetin	56,65	CBP	24,27	quercetin	CBP	MESH:D011794	1387	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nmod|effect	-LSB- The roles of c-Jun and CBP in the inhibitory effect of quercetin on prostate_cancer cells -RSB- .
24649026	0	quercetin	11,20	CDK4	24,28	quercetin	CDK4	MESH:D011794	1019	Chemical	Gene	START_ENTITY|nmod|mRNA mRNA|compound|END_ENTITY	Effects of quercetin on CDK4 mRNA and protein expression in A549 cells infected by H1N1 .
20377179	0	quercetin	21,30	COX-2	56,61	quercetin	COX-2	MESH:D011794	29527(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|compound|END_ENTITY	Protective effect of quercetin against arsenite-induced COX-2 expression by targeting PI3K in rat liver epithelial cells .
21680781	0	quercetin	10,19	CYP3A	23,28	quercetin	CYP3A	MESH:D011794	1576	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|compound|END_ENTITY	Effect of quercetin on CYP3A activity in Chinese healthy participants .
12508355	0	quercetin	41,50	GM-CSF_and_B7-1	117,132	quercetin	GM-CSF and B7-1	MESH:D011794	1437;941	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nsubj|effect	Synergetic anticancer effect of combined quercetin and recombinant adenoviral vector expressing human wild-type p53 , GM-CSF_and_B7-1 genes on hepatocellular_carcinoma cells in vitro .
17364964	0	quercetin	14,23	HIF-1alpha	65,75	quercetin	HIF-1alpha	MESH:D011794	3091	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	The flavonoid quercetin induces hypoxia-inducible_factor-1alpha -LRB- HIF-1alpha -RRB- and inhibits cell proliferation by depleting intracellular iron .
19390785	0	quercetin	55,64	Heme_oxygenase-1	0,16	quercetin	Heme oxygenase-1	MESH:D011794	24451(Tax:10116)	Chemical	Gene	actions|nmod|START_ENTITY mediates|dobj|actions mediates|nsubj|END_ENTITY	Heme_oxygenase-1 mediates the anti-allergic actions of quercetin in rodent mast cells .
16426496	0	quercetin	25,34	IL-6	38,42	quercetin	IL-6	MESH:D011794	3569	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|production production|compound|END_ENTITY	The inhibitory effect of quercetin on IL-6 production by LPS-stimulated neutrophils .
16532021	0	quercetin	90,99	IL-6	37,41	quercetin	IL-6	MESH:D011794	3569	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of IL-1-induced selective IL-6 release from human mast cells and inhibition by quercetin .
19013512	0	quercetin	29,38	MAO-A	0,5	quercetin	MAO-A	MESH:D011794	4128	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	MAO-A inhibitory activity of quercetin from Calluna_vulgaris -LRB- L. -RRB- Hull .
17509533	0	quercetin	14,23	MRP1	51,55	quercetin	MRP1	MESH:D011794	4363	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|nmod|END_ENTITY	The effect of quercetin phase II metabolism on its MRP1 and MRP2 inhibiting potential .
12849725	0	quercetin	62,71	NQO1	31,35	quercetin	NQO1	MESH:D011794	1728	Chemical	Gene	cytotoxicity|compound|START_ENTITY reductase|nmod|cytotoxicity reductase|dep|END_ENTITY	The role of quinone reductase -LRB- NQO1 -RRB- and quinone chemistry in quercetin cytotoxicity .
15670828	0	quercetin	67,76	NQO1	26,30	quercetin	NQO1	MESH:D011794	1728	Chemical	Gene	protection|nmod|START_ENTITY role|nmod|protection role|appos|END_ENTITY	No role of DT-diaphorase -LRB- NQO1 -RRB- in the protection against oxidized quercetin .
17462537	0	quercetin	60,69	NQO1	41,45	quercetin	NQO1	MESH:D011794	1728	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Action of Nrf2 and Keap1 in ARE-mediated NQO1 expression by quercetin .
19576171	0	quercetin	62,71	Nrf2	18,22	quercetin	Nrf2	MESH:D011794	4780	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Essential role of Nrf2 in keratinocyte protection from UVA by quercetin .
18619980	0	quercetin	110,119	P-glycoprotein	146,160	quercetin	P-glycoprotein	MESH:D011794	287115(Tax:10116)	Chemical	Gene	combination|nmod|START_ENTITY irinotecan|nmod|combination absorption|nmod|irinotecan evidence|nmod|absorption evidence|dep|contribution contribution|nmod|END_ENTITY	Pre-clinical evidence for altered absorption and biliary excretion of irinotecan -LRB- CPT-11 -RRB- in combination with quercetin : possible contribution of P-glycoprotein .
19221726	0	quercetin	21,30	P-glycoprotein	87,101	quercetin	P-glycoprotein	MESH:D011794	5243	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|substrate substrate|nmod|END_ENTITY	Short-term effect of quercetin on the pharmacokinetics of fexofenadine , a substrate of P-glycoprotein , in healthy volunteers .
23422925	0	quercetin	10,19	P-glycoprotein	23,37	quercetin	P-glycoprotein	MESH:D011794	5243	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|ability ability|amod|END_ENTITY	Effect of quercetin on P-glycoprotein transport ability in Chinese healthy subjects .
9105411	0	quercetin	10,19	P-glycoprotein	77,91	quercetin	P-glycoprotein	MESH:D011794	5243	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of quercetin on Hoechst_33342 transport by purified and reconstituted P-glycoprotein .
16156274	0	quercetin	12,21	PDGF-B	49,55	quercetin	PDGF-B	MESH:D011794	24628(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of quercetin and enalapril on amount of PDGF-B and VEGF-1 in kidney of diabetic rats -RSB- .
12015078	0	quercetin	25,34	PML	38,41	quercetin	PML	MESH:D011794	5371	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	-LSB- Study of the effects of quercetin on PML gene and protein expression and localization in leukemia cells -RSB- .
24141791	0	quercetin	6,15	SERCA1	67,73	quercetin	SERCA1	MESH:D011794	487	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	Novel quercetin derivatives in treatment of peroxynitrite-oxidized SERCA1 .
21932938	0	quercetin	14,23	SOX9	41,45	quercetin	SOX9	MESH:D011794	20682(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|nmod|END_ENTITY	The effect of quercetin on expression of SOX9 and subsequent release of type II collagen in spheno-occipital synchondroses of organ-cultured mice .
12065059	0	quercetin	51,60	SULT1A1	39,46	quercetin	SULT1A1	MESH:D011794	6817	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of phenol sulfotransferase -LRB- SULT1A1 -RRB- by quercetin in human adult and foetal livers .
23596717	0	quercetin	11,20	TGF-beta1	42,51	quercetin	TGF-beta1	MESH:D011794	7040	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of quercetin on the expression of TGF-beta1 in human embryonic lung fibroblasts activated by the silicotic alveolar macrophages -RSB- .
17103373	4	quercetin	843,852	THP-1	869,874	quercetin	S100B	MESH:D011794	6285	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	S100B treatment with quercetin and catechin in THP-1 cells had inhibitory effects on the expression of pro-inflammatory genes and protein levels .
19664387	0	quercetin	12,21	VEGF-C	43,49	quercetin	VEGF-C	MESH:D011794	7424	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of quercetin on the expression of VEGF-C and VEGFR-3 in human cancer MGC-803 cells -RSB- .
22141284	0	quercetin	22,31	X-linked_inhibitor_of_apoptosis_protein	119,158	quercetin	X-linked inhibitor of apoptosis protein	MESH:D011794	63879(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|involvement involvement|nmod|END_ENTITY	Protective effects of quercetin against status_epilepticus induced hippocampal_neuronal_injury in rats : involvement of X-linked_inhibitor_of_apoptosis_protein .
15327830	0	quercetin	35,44	androgen_receptor	102,119	quercetin	androgen receptor	MESH:D011794	367	Chemical	Gene	induced|nmod|START_ENTITY c-Jun|acl|induced Overexpression|nmod|c-Jun inhibits|nsubj|Overexpression inhibits|dobj|expression expression|nmod|END_ENTITY	Overexpression of c-Jun induced by quercetin and resverol inhibits the expression and function of the androgen_receptor in human prostate_cancer cells .
20148354	0	quercetin	49,58	androgen_receptor	19,36	quercetin	androgen receptor	MESH:D011794	367	Chemical	Gene	function|nmod|START_ENTITY function|nsubj|Suppression Suppression|nmod|END_ENTITY	Suppression of the androgen_receptor function by quercetin through protein-protein interactions of Sp1 , c-Jun , and the androgen_receptor in human prostate_cancer cells .
24963805	0	quercetin	75,84	apolipoprotein_A-I	21,39	quercetin	apolipoprotein A-I	MESH:D011794	335	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|expression expression|compound|END_ENTITY	Induction of hepatic apolipoprotein_A-I gene expression by the isoflavones quercetin and isoquercetrin .
12216835	0	quercetin	68,77	apolipoprotein_B	11,27	quercetin	apolipoprotein B	MESH:D011794	338	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|secretion secretion|compound|END_ENTITY	Intestinal apolipoprotein_B secretion is inhibited by the flavonoid quercetin : potential role of microsomal triglyceride transfer protein and diacylglycerol acyltransferase .
15327830	0	quercetin	35,44	c-Jun	18,23	quercetin	c-Jun	MESH:D011794	3725	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Overexpression of c-Jun induced by quercetin and resverol inhibits the expression and function of the androgen_receptor in human prostate_cancer cells .
20731900	0	quercetin	11,20	caspase-3	53,62	quercetin	caspase-3	MESH:D011794	836	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of quercetin on the expression and growth of caspase-3 in lung adenocarcinoma_cancer cell line A549 . -RSB- .
12168845	0	quercetin	77,86	epidermal_growth_factor_receptor	16,48	quercetin	epidermal growth factor receptor	MESH:D011794	1956	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Blockade of the epidermal_growth_factor_receptor tyrosine kinase activity by quercetin and luteolin leads to growth inhibition and apoptosis of pancreatic_tumor cells .
19838946	0	quercetin	11,20	glutathione-S_transferase	45,70	quercetin	glutathione-S transferase	MESH:D011794	58962(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of quercetin and catechin on hepatic glutathione-S_transferase -LRB- GST -RRB- , NAD -LRB- P -RRB- H_quinone_oxidoreductase_1 -LRB- NQO1 -RRB- , and antioxidant enzyme activity levels in rats .
12686490	0	quercetin	68,77	glutathione_S-transferase_P1-1	20,50	quercetin	glutathione S-transferase P1-1	MESH:D011794	2950	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of human glutathione_S-transferase_P1-1 by the flavonoid quercetin .
16601819	0	quercetin	14,23	glutathione_reductase	40,61	quercetin	glutathione reductase	MESH:D011794	2936	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of quercetin and galangin on glutathione_reductase .
17559999	0	quercetin	38,47	glyceraldehyde-3-phosphate_dehydrogenase	51,91	quercetin	glyceraldehyde-3-phosphate dehydrogenase	MESH:D011794	2597	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Antioxidant and prooxidant effects of quercetin on glyceraldehyde-3-phosphate_dehydrogenase .
23849943	0	quercetin	11,20	heparanase	42,52	quercetin	heparanase	MESH:D011794	10855	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Impact of quercetin on the expression of heparanase in cervical_cancer cells -RSB- .
16171798	0	quercetin	38,47	iNOS	14,18	quercetin	iNOS	MESH:D011794	18126(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Inhibition of iNOS gene expression by quercetin is mediated by the inhibition of IkappaB kinase , nuclear factor-kappa B and STAT1 , and depends on heme_oxygenase-1 induction in mouse_BV-2 microglia .
21455760	0	quercetin	11,20	lysozyme	24,32	quercetin	lysozyme	MESH:D011794	4069	Chemical	Gene	Binding|nmod|START_ENTITY Binding|acl|END_ENTITY	Binding of quercetin to lysozyme as probed by spectroscopic analysis and molecular simulation .
20579867	0	quercetin	10,19	miR-155	122,129	quercetin	miR-155	MESH:D011794	387173(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|role role|nmod|END_ENTITY	Effect of quercetin and its metabolites isorhamnetin and quercetin-3-glucuronide on inflammatory gene expression : role of miR-155 .
22943758	0	quercetin	12,21	p65	43,46	quercetin	p65	MESH:D011794	25716(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effects of quercetin on nuclear factor-kB p65 expression in renal ubiquitin-proteasome system of diabetic rats -RSB- .
25858763	0	quercetin	22,31	p65	129,132	quercetin	p65	MESH:D011794	25716(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|acl|inhibiting inhibiting|dobj|END_ENTITY	Protective effects of quercetin against chronic mixed reflux_esophagitis in rats -LRB- Rattus_norvegicus -RRB- by inhibiting the NF-kappaB p65 and interleukin-8 signaling pathway .
20228421	0	quercetin	10,19	paraoxonase_1	23,36	quercetin	paraoxonase 1	MESH:D011794	18979(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effect of quercetin on paraoxonase_1 activity -- studies in cultured cells , mice and humans .
20307882	0	quercetin	48,57	paraoxonase_1	61,74	quercetin	paraoxonase 1	MESH:D011794	18979(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|status status|amod|END_ENTITY	Impact of apolipoprotein_E genotype and dietary quercetin on paraoxonase_1 status in apoE3 and apoE4 transgenic_mice .
21893570	0	quercetin	73,82	paraoxonase_1	97,110	quercetin	paraoxonase 1	MESH:D011794	84024(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY model|dep|effects Phytotherapy|nmod|model involve|nsubj|Phytotherapy involve|dobj|activation activation|amod|END_ENTITY	Phytotherapy in a rat model of hyperoxaluria : the antioxidant effects of quercetin involve serum paraoxonase_1 activation .
25328927	0	quercetin	32,41	paraoxonase_1	67,80	quercetin	paraoxonase 1	MESH:D011794	84024(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|activity activity|amod|END_ENTITY	Onion extract -LRB- Allium cepa L. -RRB- , quercetin and catechin up-regulate paraoxonase_1 activity with concomitant protection against low-density lipoprotein oxidation in male Wistar_rats subjected to oxidative stress .
19865538	0	quercetin	10,19	paraoxonase_2	23,36	quercetin	paraoxonase 2	MESH:D011794	5445	Chemical	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	Effect of quercetin on paraoxonase_2 levels in RAW264 .7 macrophages and in human monocytes -- role of quercetin metabolism .
19865538	0	quercetin	100,109	paraoxonase_2	23,36	quercetin	paraoxonase 2	MESH:D011794	5445	Chemical	Gene	metabolism|compound|START_ENTITY role|nmod|metabolism Effect|dep|role Effect|nmod|quercetin quercetin|nmod|levels levels|amod|END_ENTITY	Effect of quercetin on paraoxonase_2 levels in RAW264 .7 macrophages and in human monocytes -- role of quercetin metabolism .
22402395	0	quercetin	10,19	redox_factor_1	84,98	quercetin	redox factor 1	MESH:D011794	11792(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|role role|nmod|END_ENTITY	Effect of quercetin on inflammatory gene expression in mice liver in vivo - role of redox_factor_1 , miRNA-122 and miRNA-125b .
22647223	0	quercetin	93,102	thrombin	106,114	quercetin	thrombin	MESH:D011794	2147	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Metabolism-based synthesis , biologic evaluation and SARs analysis of O-methylated analogs of quercetin as thrombin inhibitors .
26806540	0	quercetin	56,65	transient_receptor_potential_ankyrin_1	14,52	quercetin	transient receptor potential ankyrin 1	MESH:D011794	8989	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of transient_receptor_potential_ankyrin_1 by quercetin and its analogs .
9812753	0	quercetin	21,30	tumor_necrosis_factor	34,55	quercetin	tumor necrosis factor	MESH:D011794	7124	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activities activities|compound|END_ENTITY	Inhibitory effect of quercetin on tumor_necrosis_factor and interleukin-1_beta pro-osteoclastic activities .
17873839	0	quercetin	11,20	tyrosinase	33,43	quercetin	tyrosinase	MESH:D011794	22173(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|cells cells|amod|END_ENTITY	Effects of quercetin on mushroom tyrosinase and B16-F10 melanoma cells .
23385462	0	quercitrin	18,28	RSK	77,80	quercitrin	RSK	MESH:C012526	20111(Tax:10090)	Chemical	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	Identification of quercitrin as an inhibitor of the p90 S6 ribosomal kinase -LRB- RSK -RRB- : structure of its complex with the N-terminal domain of RSK2 at 1.8 resolution .
18716446	0	quercitrin_gallate	25,43	iNOS	47,51	quercitrin gallate	iNOS	null	18126(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	The inhibitory effect of quercitrin_gallate on iNOS expression induced by lipopolysaccharide in Balb/c mice .
11512044	0	quetiapine	36,46	5-HT2A_receptor	8,23	quetiapine	5-HT2A receptor	MESH:C069541	3356	Chemical	Gene	blockade|nmod|START_ENTITY blockade|amod|END_ENTITY	In vivo 5-HT2A_receptor blockade by quetiapine : an R91150 single photon emission tomography study .
24240480	0	quetiapine	79,89	ABCB1	13,18	quetiapine	ABCB1	MESH:C069541	5243	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY polymorphisms|nmod|pharmacokinetics polymorphisms|nsubj|Influence Influence|nmod|END_ENTITY	Influence of ABCB1 and CYP3A5 genetic polymorphisms on the pharmacokinetics of quetiapine in healthy volunteers .
15933483	0	quetiapine	7,17	SRI	21,24	quetiapine	SRI	MESH:C069541	6717	Chemical	Gene	Adding|dobj|START_ENTITY Adding|nmod|END_ENTITY	Adding quetiapine to SRI in treatment-resistant obsessive-compulsive_disorder : a randomized controlled treatment study .
16713676	0	quetiapine	11,21	brain-derived_neurotrophic_factor	29,62	quetiapine	brain-derived neurotrophic factor	MESH:C069541	24225(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|amod|END_ENTITY	Effects of quetiapine on the brain-derived_neurotrophic_factor expression in the hippocampus and neocortex of rats .
22939945	0	quetiapine	91,101	brain-derived_neurotrophic_factor	11,44	quetiapine	brain-derived neurotrophic factor	MESH:C069541	627	Chemical	Gene	treatment|nmod|START_ENTITY changes|nmod|treatment changes|amod|END_ENTITY	Peripheral brain-derived_neurotrophic_factor changes along treatment with extended release quetiapine during acute mood episodes : an open-label trial in drug-free patients with bipolar_disorder .
22732518	0	quetiapine	97,107	norepinephrine_transporter	38,64	quetiapine	norepinephrine transporter	MESH:C069541	6530	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nmod|effect	Role of concomitant inhibition of the norepinephrine_transporter for the antipsychotic effect of quetiapine .
23809226	0	quetiapine_XR	85,98	Norepinephrine_transporter	0,26	quetiapine XR	Norepinephrine transporter	null	6530	Chemical	Gene	occupancy|nmod|START_ENTITY occupancy|amod|END_ENTITY	Norepinephrine_transporter occupancy in the human brain after oral administration of quetiapine_XR .
21779761	0	quinacrine	41,51	Kir	15,18	quinacrine	Kir	MESH:D011796	3805	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Mechanisms for Kir channel inhibition by quinacrine : acute pore block of Kir2.x channels and interference in PIP2 interaction with Kir2.x and Kir6 .2 channels .
20424169	0	quinacrine	37,47	NF-kappaB	14,23	quinacrine	NF-kappaB	MESH:D011796	4790	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Inhibition of NF-kappaB signaling by quinacrine is cytotoxic to human colon_carcinoma cell lines and is synergistic in combination with tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- or oxaliplatin .
21518868	0	quinacrine	64,74	NF-kappaB	111,120	quinacrine	NF-kappaB	MESH:D011796	4790	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	FER tyrosine kinase -LRB- FER -RRB- overexpression mediates resistance to quinacrine through EGF-dependent activation of NF-kappaB .
8569417	0	quinacrine	56,66	phospholipase_inhibitor	32,55	quinacrine	phospholipase inhibitor	MESH:D011796	646627	Chemical	Gene	START_ENTITY|nsubj|action action|nmod|END_ENTITY	Cerebroprotective action of the phospholipase_inhibitor quinacrine in the ischemia/reperfused gerbil hippocampus .
12457623	0	quinapril	19,28	ACE	4,7	quinapril	ACE	MESH:C041125	11421(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	The ACE inhibitor , quinapril , ameliorates peritoneal fibrosis in an encapsulating peritoneal sclerosis model in mice .
15109241	0	quinapril	29,38	ACE	15,18	quinapril	ACE	MESH:C041125	100064801(Tax:9796)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|inhibitor inhibitor|compound|END_ENTITY	Effects of the ACE inhibitor quinapril on echocardiographic variables in horses with mitral_valve_insufficiency .
15526248	0	quinapril	20,29	ACE	51,54	quinapril	ACE	MESH:C041125	1636	Chemical	Gene	effects|nmod|START_ENTITY depend|nsubj|effects depend|nmod|polymorphism polymorphism|compound|END_ENTITY	Vascular effects of quinapril completely depend on ACE insertion/deletion polymorphism .
1691402	0	quinapril	12,21	ACE	29,32	quinapril	ACE	MESH:C041125	1636	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Overview of quinapril , a new ACE inhibitor .
2189620	0	quinapril	22,31	ACE	61,64	quinapril	ACE	MESH:C041125	1636	Chemical	Gene	profile|nmod|START_ENTITY difference|nsubj|profile difference|nmod|inhibitors inhibitors|compound|END_ENTITY	The safety profile of quinapril : is there a difference among ACE inhibitors ?
7713100	0	quinapril	47,56	ACE	24,27	quinapril	ACE	MESH:C041125	1636	Chemical	Gene	effects|dep|START_ENTITY effects|nmod|inhibition inhibition|compound|END_ENTITY	Dose-related effects of ACE inhibition in man : quinapril in patients with moderate congestive_heart_failure .
9231041	0	quinapril	26,35	ACE	8,11	quinapril	ACE	MESH:C041125	24310(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY END_ENTITY|acl|inhibition	Chronic ACE inhibition by quinapril modulates central vasopressinergic system .
8585063	0	quinapril	71,80	ACe	41,44	quinapril	ACe	MESH:C041125	610668(Tax:9615)	Chemical	Gene	-RSB-|amod|START_ENTITY comparison|nmod|-RSB- Treatment|dep|comparison Treatment|nmod|heart_failure heart_failure|nmod|dogs dogs|nmod|inhibitors inhibitors|compound|END_ENTITY	-LSB- Treatment of heart_failure in dogs with ACe inhibitors : comparison of quinapril and captopril -RSB- .
10784227	0	quinapril	44,53	Angiotensin-converting_enzyme	0,29	quinapril	Angiotensin-converting enzyme	MESH:C041125	1636	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Angiotensin-converting_enzyme inhibition by quinapril blocks the albuminuric effect of atrial natriuretic peptide in Type 1 diabetes and microalbuminuria .
3309510	0	quinapril	46,55	Angiotensin-converting_enzyme	0,29	quinapril	Angiotensin-converting enzyme	MESH:C041125	24310(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Angiotensin-converting_enzyme inhibition with quinapril -LRB- CI-906 -RRB- and captopril in spontaneously hypertensive rats with suppressed renin-angiotensin system .
8759064	0	quinapril	46,55	Angiotensin-converting_enzyme	0,29	quinapril	Angiotensin-converting enzyme	MESH:C041125	1636	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Angiotensin-converting_enzyme inhibition with quinapril improves endothelial vasomotor dysfunction in patients with coronary_artery_disease .
12616664	0	quinapril	20,29	angiotensin-converting_enzyme	86,115	quinapril	angiotensin-converting enzyme	MESH:C041125	1636	Chemical	Gene	Pharmacokinetics|nmod|START_ENTITY Pharmacokinetics|dep|assessment assessment|nmod|substitution substitution|nmod|treatment treatment|amod|END_ENTITY	Pharmacokinetics of quinapril in children : assessment during substitution for chronic angiotensin-converting_enzyme inhibitor treatment .
1375675	0	quinapril	100,109	angiotensin-converting_enzyme	30,59	quinapril	angiotensin-converting enzyme	MESH:C041125	24310(Tax:10116)	Chemical	Gene	rats|amod|START_ENTITY inhibition|nmod|rats inhibition|nmod|END_ENTITY	Prolonged inhibition of local angiotensin-converting_enzyme after single or repeated treatment with quinapril in spontaneously hypertensive rats .
1376798	0	quinapril	71,80	angiotensin-converting_enzyme	85,114	quinapril	angiotensin-converting enzyme	MESH:C041125	1636	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Renal structure and function in rats after suprapharmacologic doses of quinapril , an angiotensin-converting_enzyme inhibitor .
1546639	0	quinapril	102,111	angiotensin-converting_enzyme	19,48	quinapril	angiotensin-converting enzyme	MESH:C041125	1636	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|inhibitors inhibitors|amod|END_ENTITY	Adverse effects of angiotensin-converting_enzyme inhibitors in antihypertensive therapy with focus on quinapril .
1778358	0	quinapril	100,109	angiotensin-converting_enzyme	59,88	quinapril	angiotensin-converting enzyme	MESH:C041125	24310(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|studies studies|nmod|rats rats|nmod|inhibitor inhibitor|amod|END_ENTITY	Fertility and perinatal/postnatal studies in rats with the angiotensin-converting_enzyme inhibitor , quinapril .
2196144	0	quinapril	23,32	angiotensin-converting_enzyme	42,71	quinapril	angiotensin-converting enzyme	MESH:C041125	1636	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Hemodynamic effects of quinapril , a novel angiotensin-converting_enzyme inhibitor .
2267499	0	quinapril	79,88	angiotensin-converting_enzyme	106,135	quinapril	angiotensin-converting enzyme	MESH:C041125	24310(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Ultrastructural juxtaglomerular cell changes in normotensive rats treated with quinapril , an inhibitor of angiotensin-converting_enzyme .
8797130	0	quinapril	43,52	angiotensin-converting_enzyme	84,113	quinapril	angiotensin-converting enzyme	MESH:C041125	24310(Tax:10116)	Chemical	Gene	study|nmod|START_ENTITY END_ENTITY|nsubj|study	Acute and long-term dose-response study of quinapril on hormonal profile and tissue angiotensin-converting_enzyme in Wistar_rats .
12799093	0	quinapril	10,19	angiotensin_converting_enzyme	127,156	quinapril	angiotensin converting enzyme	MESH:C041125	1636	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|relationship relationship|nmod|polymorphisms polymorphisms|amod|END_ENTITY	Effect of quinapril , quinapril-hydrochlorothiazide , and enalapril on the bone mass of hypertensive subjects : relationship with angiotensin_converting_enzyme polymorphisms .
1708046	0	quinapril	57,66	angiotensin_converting_enzyme	76,105	quinapril	angiotensin converting enzyme	MESH:C041125	1636	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Platelet function during antihypertensive treatment with quinapril , a novel angiotensin_converting_enzyme inhibitor .
1850330	0	quinapril	11,20	angiotensin_converting_enzyme	28,57	quinapril	angiotensin converting enzyme	MESH:C041125	1636	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Effects of quinapril , a new angiotensin_converting_enzyme inhibitor , on left_ventricular_failure and survival in the cardiomyopathic hamster .
24175935	0	quinapril	11,20	angiotensin_converting_enzyme	24,53	quinapril	angiotensin converting enzyme	MESH:C041125	100064801(Tax:9796)	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Effects of quinapril on angiotensin_converting_enzyme and plasma renin activity as well as pharmacokinetic parameters of quinapril and its active metabolite , quinaprilat , after intravenous and oral administration to mature horses .
9504380	0	quinapril	11,20	mREN2	130,135	quinapril	mREN2	MESH:C041125	19702(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of quinapril , losartan and hydralazine on cardiac_hypertrophy and beta-adrenergic neuroeffector mechanisms in transgenic -LRB- mREN2 -RRB- 27 rats .
24175935	0	quinapril	11,20	renin	65,70	quinapril	renin	MESH:C041125	100054248(Tax:9796)	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Effects of quinapril on angiotensin_converting_enzyme and plasma renin activity as well as pharmacokinetic parameters of quinapril and its active metabolite , quinaprilat , after intravenous and oral administration to mature horses .
10520782	0	quinaprilat_IV	106,120	angiotensin-converting_enzyme	60,89	quinaprilat IV	angiotensin-converting enzyme	null	1636	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Improvement of myocardial_blood_flow to ischemic regions by angiotensin-converting_enzyme inhibition with quinaprilat_IV : a study using -LSB- 15O -RSB- water dobutamine stress positron emission tomography .
18702009	0	quinazoline	40,51	EGFR	93,97	quinazoline	EGFR	CHEBI:36621	1956	Chemical	Gene	START_ENTITY|dobj|inhibitors inhibitors|nmod|END_ENTITY	Synthesis and characterization of novel quinazoline type inhibitors for mutant and wild-type EGFR and RICK kinases .
26879314	0	quinazoline	28,39	EGFR	55,59	quinazoline	EGFR	CHEBI:36621	1956	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	Novel morpholin-3-one fused quinazoline derivatives as EGFR tyrosine kinase inhibitors .
9473502	0	quinazoline	16,27	endothelin_converting_enzyme-1	42,72	quinazoline	endothelin converting enzyme-1	CHEBI:36621	1889	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|nmod|END_ENTITY	Novel selective quinazoline inhibitors of endothelin_converting_enzyme-1 .
1913676	0	quinazoline	13,24	thymidylate_synthase	36,56	quinazoline	thymidylate synthase	CHEBI:36621	22171(Tax:10090)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	ICI_D1694 , a quinazoline antifolate thymidylate_synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo : a new agent for clinical study .
3008799	0	quinazoline	93,104	thymidylate_synthase	118,138	quinazoline	thymidylate synthase	CHEBI:36621	22171(Tax:10090)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|nmod|END_ENTITY	Inhibition of the growth of human hepatocellular_carcinoma in vitro and in athymic mice by a quinazoline inhibitor of thymidylate_synthase , CB3717 .
12209987	0	quinazoline_tyrosine	38,58	EGF_receptor	87,99	quinazoline tyrosine	EGF receptor	null	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Antagonistic and agonistic effects of quinazoline_tyrosine kinase inhibitors on mutant EGF_receptor function .
16837130	0	quinazoline_tyrosine	48,68	epidermal_growth_factor_receptor	12,44	quinazoline tyrosine	epidermal growth factor receptor	null	1956	Chemical	Gene	inhibitors|amod|START_ENTITY END_ENTITY|nmod|inhibitors	Blockage of epidermal_growth_factor_receptor by quinazoline_tyrosine kinase inhibitors suppresses growth of human hepatocellular_carcinoma .
18465761	0	quinazolines	105,117	EGFR	139,143	quinazolines	EGFR	MESH:D011799	1956	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|kinase kinase|amod|END_ENTITY	Allene as an alternative functional group for drug design : effect of C -- C multiple bonds conjugated with quinazolines on the inhibition of EGFR tyrosine kinase .
21254978	0	quinazolines	18,30	EGFR	42,46	quinazolines	EGFR	MESH:D011799	1956	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Novel substituted quinazolines for potent EGFR tyrosine kinase inhibitors .
11378364	0	quinazolines	15,27	EGFr	71,75	quinazolines	EGFr	MESH:D011799	13649(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Indazolylamino quinazolines and pyridopyrimidines as inhibitors of the EGFr and C-erbB-2 .
11844674	0	quinazolinones	11,25	Pgp	48,51	quinazolinones	Pgp	MESH:D052999	283871	Chemical	Gene	Studies|nmod|START_ENTITY Studies|nmod|END_ENTITY	Studies on quinazolinones as dual inhibitors of Pgp and MRP1 in multidrug resistance .
698151	0	quinestrol	15,25	prolactin	72,81	quinestrol	prolactin	MESH:D011800	5617	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of quinestrol and bromocriptine on blood_coagulation , serum prolactin and serum FSH levels in puerperal women .
26996372	0	quinic_acid	22,33	histone_deacetylase	49,68	quinic acid	histone deacetylase	MESH:D011801	9734	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Identification of new quinic_acid derivatives as histone_deacetylase inhibitors by fluorescence-based cellular assay .
11765139	0	quinidine	54,63	CYP1A1	33,39	quinidine	CYP1A1	MESH:D011802	1543	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Differential inhibition of human CYP1A1 and CYP1A2 by quinidine and quinine .
12023534	0	quinidine	70,79	CYP1A1	41,47	quinidine	CYP1A1	MESH:D011802	1543	Chemical	Gene	4-Hydroxylation|nmod|START_ENTITY 4-Hydroxylation|nmod|END_ENTITY	4-Hydroxylation of debrisoquine by human CYP1A1 and its inhibition by quinidine and quinine .
10671914	0	quinidine	46,55	CYP2D6	98,104	quinidine	CYP2D6	MESH:D011802	1565	Chemical	Gene	genes|amod|START_ENTITY genes|compound|END_ENTITY	Inhibition of debrisoquine hydroxylation with quinidine in subjects with three or more functional CYP2D6 genes .
10671914	1	quinidine	320,329	CYP2D6	139,145	quinidine	CYP2D6	MESH:D011802	1565	Chemical	Gene	doses|nmod|START_ENTITY normalised|nmod|doses normalised|nsubj|capacity capacity|compound|END_ENTITY	AIMS : To study whether the CYP2D6 capacity in ultrarapid metabolizers of debrisoquine due to duplication/multiduplication of a functional CYP2D6 gene , can be ` normalised ' by low doses of the CYP2D6 inhibitor quinidine and whether this is dose-dependent .
10671914	11	quinidine	1485,1494	CYP2D6	1575,1581	quinidine	CYP2D6	MESH:D011802	1565	Chemical	Gene	doses|nmod|START_ENTITY use|nmod|doses considered|nsubjpass|use considered|ccomp|taking taking|dobj|drugs drugs|nummod|END_ENTITY	The clinical use of low doses of quinidine as an inhibitor of CYP2D6 might be considered in ultrarapid metabolizers taking CYP2D6 metabolized drugs rather than giving increased doses of the drug .
10702886	0	quinidine	24,33	CYP2D6	14,20	quinidine	CYP2D6	MESH:D011802	1565	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of CYP2D6 by quinidine and its effects on the metabolism of cilostazol .
19103487	0	quinidine	43,52	CYP2D6	68,74	quinidine	CYP2D6	MESH:D011802	1565	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|compound|END_ENTITY	Insight into the effects of chiral isomers quinidine and quinine on CYP2D6 inhibition .
12228192	0	quinidine	65,74	CYP3A4	35,41	quinidine	CYP3A4	MESH:D011802	1576	Chemical	Gene	inactivation|nmod|START_ENTITY inactivation|nmod|END_ENTITY	Diclofenac-induced inactivation of CYP3A4 and its stimulation by quinidine .
14534517	0	quinidine	99,108	P-glycoprotein	70,84	quinidine	P-glycoprotein	MESH:D011802	5243	Chemical	Gene	blocked|nmod|START_ENTITY blocked|nsubjpass|END_ENTITY	Respiratory and miotic effects of morphine in healthy volunteers when P-glycoprotein is blocked by quinidine .
14704918	0	quinidine	73,82	P-glycoprotein	10,24	quinidine	P-glycoprotein	MESH:D011802	100008914(Tax:9986)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of P-glycoprotein on the ocular disposition of a model substrate , quinidine .
15089813	0	quinidine	14,23	P-glycoprotein	64,78	quinidine	P-glycoprotein	MESH:D011802	5243	Chemical	Gene	effect|nmod|START_ENTITY effect|acl|used used|nmod|probe probe|nmod|involvement involvement|nmod|END_ENTITY	The effect of quinidine , used as a probe for the involvement of P-glycoprotein , on the intestinal absorption and pharmacodynamics of methadone .
16258992	0	quinidine	122,131	P-glycoprotein	36,50	quinidine	P-glycoprotein	MESH:D011802	287115(Tax:10116)	Chemical	Gene	efflux|amod|START_ENTITY analysis|nmod|efflux activity|dep|analysis activity|nmod|END_ENTITY	pH-dependent functional activity of P-glycoprotein in limiting intestinal absorption of protic drugs : kinetic analysis of quinidine efflux in situ .
18444515	0	quinidine	8,17	P-glycoprotein	21,35	quinidine	P-glycoprotein	MESH:D011802	5243	Chemical	Gene	START_ENTITY|appos|substrate substrate|amod|END_ENTITY	Fate of quinidine , a P-glycoprotein substrate , in the gastrointestinal tract after oral administration in rats .
19406953	0	quinidine	20,29	P-glycoprotein	85,99	quinidine	P-glycoprotein	MESH:D011802	100008914(Tax:9986)	Chemical	Gene	kinetics|nmod|START_ENTITY coadministered|nsubj|kinetics coadministered|dobj|substrates/modulators substrates/modulators|amod|END_ENTITY	Vitreal kinetics of quinidine in rabbits in the presence of topically coadministered P-glycoprotein substrates/modulators .
22764568	0	quinidine	45,54	P-glycoprotein	58,72	quinidine	P-glycoprotein	MESH:D011802	287115(Tax:10116)	Chemical	Gene	absorption|nmod|START_ENTITY Characterization|nmod|absorption Characterization|appos|substrate substrate|amod|END_ENTITY	Characterization of intestinal absorption of quinidine , a P-glycoprotein substrate , given as a powder in rats .
26248047	0	quinidine	14,23	P-glycoprotein	34,48	quinidine	P-glycoprotein	MESH:D011802	5243	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	The effect of quinidine , a strong P-glycoprotein inhibitor , on the pharmacokinetics and central nervous system distribution of naloxegol .
26248047	0	quinidine	14,23	P-glycoprotein	34,48	quinidine	P-glycoprotein	MESH:D011802	5243	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	The effect of quinidine , a strong P-glycoprotein inhibitor , on the pharmacokinetics and central nervous system distribution of naloxegol .
8250956	0	quinidine	80,89	alpha_1-acidglycoprotein	10,34	quinidine	alpha 1-acidglycoprotein	MESH:D011802	497200(Tax:9913)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of alpha_1-acidglycoprotein on myocardial uptake and pharmacodynamics of quinidine in perfused rat heart .
10381752	0	quinidine	87,96	cytochrome_P-450	20,36	quinidine	cytochrome P-450	MESH:D011802	4051	Chemical	Gene	methylhydroxylation|nmod|START_ENTITY Activation|acl|methylhydroxylation Activation|nmod|meloxicam_5 meloxicam_5|amod|END_ENTITY	Activation of human cytochrome_P-450 3A4-catalyzed meloxicam_5 ' - methylhydroxylation by quinidine and hydroquinidine in vitro .
3748010	0	quinidine	13,22	cytochrome_P-450	38,54	quinidine	cytochrome P-450	MESH:D011802	4051	Chemical	Gene	Oxidation|nmod|START_ENTITY Oxidation|nmod|END_ENTITY	Oxidation of quinidine by human liver cytochrome_P-450 .
16162505	0	quinidine	7,16	cytochrome_P450_2D6	33,52	quinidine	cytochrome P450 2D6	MESH:D011802	1565	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|nmod|END_ENTITY	Why is quinidine an inhibitor of cytochrome_P450_2D6 ?
1763518	0	quinidine	40,49	debrisoquine_4-hydroxylase	125,151	quinidine	debrisoquine 4-hydroxylase	MESH:D011802	24303(Tax:10116)	Chemical	Gene	inhibitor|nmod|START_ENTITY inhibitor|nmod|methoxyphenamine methoxyphenamine|acl:relcl|involve involve|xcomp|END_ENTITY	Quinine is a more potent inhibitor than quinidine in rat of the oxidative metabolic routes of methoxyphenamine which involve debrisoquine_4-hydroxylase .
2775304	0	quinidine	72,81	debrisoquine_4-hydroxylase	33,59	quinidine	debrisoquine 4-hydroxylase	MESH:D011802	25053(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	The specificity of inhibition of debrisoquine_4-hydroxylase activity by quinidine and quinine in the rat is the inverse of that in man .
3674164	0	quinidine	21,30	pseudocholinesterase	41,61	quinidine	pseudocholinesterase	MESH:D011802	590	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nsubj|effect	Inhibitory effect of quinidine on plasma pseudocholinesterase activity in pregnant women .
946356	1	quinine	56,63	ERG	93,96	quinine	ERG	MESH:D011803	101110646	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	I. Effects of quinine and chloroquine on the sheep ERG .
18977034	0	quinine	24,31	MnSOD	111,116	quinine	MnSOD	MESH:D011803	6648	Chemical	Gene	gene|amod|START_ENTITY gene|dep|END_ENTITY	Additive effect between quinine oxidoreductase gene -LRB- NQO1 : Pro187Ser -RRB- and manganese_superoxide dismutase gene -LRB- MnSOD : Ala-9Val -RRB- polymorphisms on tardive_dyskinesia in patients with schizophrenia .
18977034	0	quinine	24,31	NQO1	53,57	quinine	NQO1	MESH:D011803	1728	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Additive effect between quinine oxidoreductase gene -LRB- NQO1 : Pro187Ser -RRB- and manganese_superoxide dismutase gene -LRB- MnSOD : Ala-9Val -RRB- polymorphisms on tardive_dyskinesia in patients with schizophrenia .
24716985	0	quinine	13,20	NQO1	39,43	quinine	NQO1	MESH:D011803	1728	Chemical	Gene	oxidoreductase|amod|START_ENTITY oxidoreductase|appos|END_ENTITY	The NAD -LRB- P -RRB- H : quinine oxidoreductase 1 -LRB- NQO1 -RRB- gene 609_C > T polymorphism is associated with gastric_cancer risk : evidence from a case-control study and a meta-analysis .
26059226	0	quinine	87,94	NQO1	113,117	quinine	NQO1	MESH:D011803	1728	Chemical	Gene	oxidoreductase|nsubj|START_ENTITY oxidoreductase|dobj|1 1|appos|END_ENTITY	HIV-1 Rev downregulates Tat expression and viral replication via modulation of NAD -LRB- P -RRB- H : quinine oxidoreductase 1 -LRB- NQO1 -RRB- .
18538895	0	quinine	30,37	NQO2	54,58	quinine	NQO2	MESH:D011803	4835	Chemical	Gene	oxidoreductase|amod|START_ENTITY oxidoreductase|appos|END_ENTITY	Investigation of a functional quinine oxidoreductase -LRB- NQO2 -RRB- polymorphism and cognitive_decline .
10683873	1	quinine	147,154	Part_8	48,54	quinine	Part 8	MESH:D011803	54625	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|dep|Effect	Part_8 : Effect of pectins and bile_acid preparations forming stable mixed micelles on transport of quinine in vitro .
1546958	0	quinine	46,53	THP1	121,125	quinine	THP1	MESH:D011803	2736	Chemical	Gene	induced|nmod|START_ENTITY induced|nmod|END_ENTITY	Changes in phospholipid metabolism induced by quinine , 4-aminopyridine and tetraethylammonium in the monocytic cell line THP1 .
10695778	0	quinine	15,22	tumor_necrosis_factor	58,79	quinine	tumor necrosis factor	MESH:D011803	7124	Chemical	Gene	treatment|amod|START_ENTITY effects|nmod|treatment effects|nmod|levels levels|compound|END_ENTITY	The effects of quinine and artesunate treatment on plasma tumor_necrosis_factor levels in malaria-infected patients .
11735393	0	quinol	60,66	cytochrome_b	84,96	quinol	cytochrome b	CHEBI:17594	4519	Chemical	Gene	oxidation|amod|START_ENTITY oxidation|nmod|END_ENTITY	Deuterium kinetic isotope effects in the p-side pathway for quinol oxidation by the cytochrome_b -LRB- 6 -RRB- f complex .
18587424	0	quinol	25,31	thioredoxin	45,56	quinol	thioredoxin	CHEBI:17594	7295	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	PMX464 , a thiol-reactive quinol and putative thioredoxin inhibitor , inhibits NF-kappaB-dependent proinflammatory activation of alveolar epithelial cells .
19843078	0	quinoline	57,66	P-selectin	96,106	quinoline	P-selectin	MESH:C037219	6403	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|inhibitors inhibitors|nmod|END_ENTITY	Combined 3D-QSAR modeling and molecular docking study on quinoline derivatives as inhibitors of P-selectin .
23354020	0	quinoline	36,45	PDE10A	61,67	quinoline	PDE10A	MESH:C037219	10846	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Inhibition mechanism exploration of quinoline derivatives as PDE10A inhibitors by in silico analysis .
22206487	0	quinoline	55,64	quinone_reductase_2	124,143	quinoline	quinone reductase 2	MESH:C037219	4835	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Design , synthesis , and biological evaluation of potent quinoline and pyrroloquinoline_ammosamide analogues as inhibitors of quinone_reductase_2 .
16973359	0	quinoline-3-carbonitriles	55,80	Tpl2	14,18	quinoline-3-carbonitriles	Tpl2	null	1326	Chemical	Gene	kinase|nmod|START_ENTITY kinase|amod|END_ENTITY	Inhibition of Tpl2 kinase and TNFalpha production with quinoline-3-carbonitriles for the treatment of rheumatoid_arthritis .
19402754	0	quinoline-3-carboxamides	100,124	S100A9	24,30	quinoline-3-carboxamides	S100A9	null	6280	Chemical	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of human S100A9 as a novel target for treatment of autoimmune_disease via binding to quinoline-3-carboxamides .
20943391	0	quinoline_amide	47,62	VEGFR-2	84,91	quinoline amide	VEGFR-2	null	3791	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Design , synthesis and biological evaluation of quinoline_amide derivatives as novel VEGFR-2 inhibitors .
26827943	0	quinolinecarboxylic_acid	11,35	PAK2	96,100	quinolinecarboxylic acid	PAK2	null	5062	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Prenylated quinolinecarboxylic_acid derivative suppresses immune response through inhibition of PAK2 .
16155209	0	quinolinediones	42,57	Cdc25B	20,26	quinolinediones	Cdc25B	null	994	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Redox regulation of Cdc25B by cell-active quinolinediones .
25456383	0	quinolines	98,108	PDE10A	118,124	quinolines	PDE10A	MESH:D011804	63885(Tax:10116)	Chemical	Gene	evaluation|nmod|START_ENTITY evaluation|nmod|END_ENTITY	Synthesis and preliminary biological evaluation of potent and selective 2 - -LRB- 3-alkoxy-1-azetidinyl -RRB- quinolines as novel PDE10A inhibitors with improved solubility .
15078100	0	quinolines	85,95	quinone_oxidoreductase_2	21,45	quinolines	quinone oxidoreductase 2	MESH:D011804	4835	Chemical	Gene	START_ENTITY|nsubj|mechanism mechanism|nmod|END_ENTITY	Kinetic mechanism of quinone_oxidoreductase_2 and its inhibition by the antimalarial quinolines .
10964490	0	quinolinic_acid	56,71	BDNF	28,32	quinolinic acid	BDNF	MESH:D017378	627	Chemical	Gene	expression|nmod|START_ENTITY expression|nsubj|regulation regulation|nmod|END_ENTITY	Developmental regulation of BDNF and NT-3 expression by quinolinic_acid in the striatum and its main connections .
24833554	0	quinolinic_acid	83,98	Cathepsin_D	11,22	quinolinic acid	Cathepsin D	MESH:D017378	1509	Chemical	Gene	START_ENTITY|nsubj|Changes Changes|nmod|END_ENTITY	Changes in Cathepsin_D and Beclin-1 mRNA and protein expression by the excitotoxin quinolinic_acid in human astrocytes and neurons .
7881035	0	quinolinic_acid	84,99	GFAP	14,18	quinolinic acid	GFAP	MESH:D017378	24387(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of GFAP in the striatum and its projection areas in response to striatal quinolinic_acid lesion in rats .
26598832	5	quinolinic_acid	522,537	QPRT	565,569	quinolinic acid	qprt	MESH:D017378	67375(Tax:10090)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	We generated mice that are missing the quinolinic_acid phosphoribosyltransferase -LRB- QPRT -RRB- gene .
20223279	0	quinolinic_acid	29,44	RAGE	61,65	quinolinic acid	RAGE	MESH:D017378	81722(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY involvement|nmod|effect involvement|nmod|END_ENTITY	On the early toxic effect of quinolinic_acid : involvement of RAGE .
18483877	0	quinolinic_acid	102,117	Somatostatin	0,12	quinolinic acid	Somatostatin	MESH:D017378	6750	Chemical	Gene	neurotoxicity|amod|START_ENTITY preservation|nmod|neurotoxicity responsible|nmod|preservation responsible|nsubj|END_ENTITY	Somatostatin in medium-sized aspiny interneurons of striatum is responsible for their preservation in quinolinic_acid and N-methyl-D-asparate-induced neurotoxicity .
2169955	1	quinolinic_acid	110,125	neurotensin	147,158	quinolinic acid	neurotensin	MESH:D017378	299757(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|content content|compound|END_ENTITY	Effects of unilateral striatal lesions with quinolinic_acid and ibotenic_acid on neurotensin content and its binding site density .
19374401	0	quinolinone	159,170	iNOS	171,175	quinolinone	iNOS	null	18126(Tax:10090)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Discovery of inducible_nitric_oxide_synthase -LRB- iNOS -RRB- inhibitor development candidate KD7332 , part_1 : Identification of a novel , potent , and selective series of quinolinone iNOS dimerization inhibitors that are orally active in rodent_pain models .
17724159	0	quinolone	50,59	qnrA1	83,88	quinolone	qnrA1	CHEBI:23765	13906559	Chemical	Gene	resistance|compound|START_ENTITY Prevalence|nmod|resistance determinant|nsubj|Prevalence determinant|dobj|END_ENTITY	Prevalence and expression of the plasmid-mediated quinolone resistance determinant qnrA1 .
21235404	0	quinolone	33,42	qnrA1	54,59	quinolone	qnrA1	CHEBI:23765	7065650(Tax:573)	Chemical	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	First report of plasmid-mediated quinolone resistance qnrA1 gene in Klebsiella_pneumoniae isolate of animal origin .
22260532	0	quinolone	39,48	qnrS2	61,66	quinolone	qnrS2	CHEBI:23765	6875946(Tax:644)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A small IncQ-type plasmid carrying the quinolone resistance -LRB- qnrS2 -RRB- gene from Aeromonas_hydrophila .
23558565	0	quinolone	75,84	topoisomerase_I	120,135	quinolone	topoisomerase I	CHEBI:23765	7150	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Design , synthesis , biological evaluation , and molecular docking studies of quinolone derivatives as potential antitumor topoisomerase_I inhibitors .
2165582	0	quinolones	11,21	TNF-alpha	25,34	quinolones	TNF-alpha	MESH:D015363	7124	Chemical	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	-LSB- Effect of quinolones on TNF-alpha production by human monocytes -RSB- .
3496323	0	quinolones	11,21	interleukin_1	25,38	quinolones	interleukin 1	MESH:D015363	3552	Chemical	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Effects of quinolones on interleukin_1 production in vitro by human monocytes .
23689721	0	quinolones	78,88	qnrS1	29,34	quinolones	qnrS1	MESH:D015363	20467117	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of plasmid-carried qnrS1 in Escherichia_coli by naturally occurring quinolones and quorum-sensing signal molecules .
1689279	0	quinolones	11,21	tumor_necrosis_factor	25,46	quinolones	tumor necrosis factor	MESH:D015363	7124	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Effects of quinolones on tumor_necrosis_factor production by human monocytes .
18180330	0	quinols	46,53	Thioredoxin_reductase	0,21	quinols	Thioredoxin reductase	MESH:D006873	25824	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Thioredoxin_reductase inhibition by antitumor quinols : a quinol pharmacophore effect correlating to antiproliferative activity .
14718602	0	quinone	83,90	Cdc25	91,96	quinone	Cdc25	MESH:C004532	995	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	NAD -LRB- P -RRB- H : quinone_oxidoreductase-1-dependent and - independent cytotoxicity of potent quinone Cdc25 phosphatase inhibitors .
10092053	0	quinone	156,163	DT-diaphorase	52,65	quinone	DT-diaphorase	MESH:C004532	18104(Tax:10090)	Chemical	Gene	metabolites|amod|START_ENTITY involvement|nmod|metabolites evidence|nmod|involvement Modulation|dep|evidence Modulation|nmod|hepatotoxicity hepatotoxicity|nmod|modulators modulators|amod|END_ENTITY	Modulation of halobenzene-induced hepatotoxicity by DT-diaphorase modulators , butylated_hydroxyanisole and dicoumarol : evidence for possible involvement of quinone metabolites in the toxicity of halobenzenes .
10423172	0	quinone	37,44	DT-diaphorase	14,27	quinone	DT-diaphorase	MESH:C004532	1728	Chemical	Gene	oxidoreductase|amod|START_ENTITY H|dep|oxidoreductase END_ENTITY|dep|H	Inhibition of DT-diaphorase -LRB- NAD -LRB- P -RRB- H : quinone oxidoreductase , EC 1.6.99.2 -RRB- by 5,6-dimethylxanthenone-4-acetic _ acid -LRB- DMXAA -RRB- and flavone-8-acetic_acid -LRB- FAA -RRB- : implications for bioreductive drug development .
11862423	0	quinone	63,70	DT-diaphorase	94,107	quinone	DT-diaphorase	MESH:C004532	1728	Chemical	Gene	agents|amod|START_ENTITY effect|nmod|agents effect|nmod|END_ENTITY	The effect of functional groups on reduction and activation of quinone bioreductive agents by DT-diaphorase .
12069105	0	quinone	32,39	DT-diaphorase	67,80	quinone	DT-diaphorase	MESH:C004532	24314(Tax:10116)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	Effect of dicumarol , a Nad -LRB- P -RRB- h : quinone acceptor oxidoreductase 1 -LRB- DT-diaphorase -RRB- inhibitor on ubiquinone redox cycling in cultured rat hepatocytes .
1373799	0	quinone	17,24	DT-diaphorase	51,64	quinone	DT-diaphorase	MESH:C004532	18104(Tax:10090)	Chemical	Gene	acceptor|amod|START_ENTITY oxidoreductase|appos|acceptor oxidoreductase|appos|END_ENTITY	Role of NAD -LRB- P -RRB- H : -LRB- quinone acceptor -RRB- oxidoreductase -LRB- DT-diaphorase -RRB- in activation of mitomycin_C under hypoxia .
1406605	0	quinone	243,250	DT-diaphorase	99,112	quinone	DT-diaphorase	MESH:C004532	24314(Tax:10116)	Chemical	Gene	acceptor|amod|START_ENTITY mechanism|dep|acceptor mechanism|dep|oxidoreductase oxidoreductase|appos|END_ENTITY	Suggested mechanism for the modulation of the activity of NAD -LRB- P -RRB- H : quinone acceptor oxidoreductase -LRB- DT-diaphorase -RRB- by menadione : interpretation of the effect of menadione on 5 ' - -LSB- p - -LRB- Fluorosulfonyl -RRB- benzoyl -RSB- adenosine labeling of rat liver NAD -LRB- P -RRB- H : quinone acceptor oxidoreductase .
1406605	0	quinone	66,73	DT-diaphorase	99,112	quinone	DT-diaphorase	MESH:C004532	24314(Tax:10116)	Chemical	Gene	oxidoreductase|amod|START_ENTITY oxidoreductase|appos|END_ENTITY	Suggested mechanism for the modulation of the activity of NAD -LRB- P -RRB- H : quinone acceptor oxidoreductase -LRB- DT-diaphorase -RRB- by menadione : interpretation of the effect of menadione on 5 ' - -LSB- p - -LRB- Fluorosulfonyl -RRB- benzoyl -RSB- adenosine labeling of rat liver NAD -LRB- P -RRB- H : quinone acceptor oxidoreductase .
1510692	0	quinone	41,48	DT-diaphorase	83,96	quinone	DT-diaphorase	MESH:C004532	1728	Chemical	Gene	sensitivity|acl|START_ENTITY sensitivity|dep|role role|nmod|END_ENTITY	The sensitivity of human tumour cells to quinone bioreductive drugs : what role for DT-diaphorase ?
1694261	0	quinone	32,39	DT-diaphorase	65,78	quinone	DT-diaphorase	MESH:C004532	24314(Tax:10116)	Chemical	Gene	oxidoreductase|amod|START_ENTITY oxidoreductase|appos|END_ENTITY	Inhibition of rat liver NAD -LRB- P -RRB- H : quinone acceptor oxidoreductase -LRB- DT-diaphorase -RRB- by flavonoids isolated from the Chinese herb scutellariae radix -LRB- Huang Qin -RRB- .
1714284	0	quinone	21,28	DT-diaphorase	53,66	quinone	DT-diaphorase	MESH:C004532	1728	Chemical	Gene	reductase|amod|START_ENTITY reductase|appos|EC EC|dep|END_ENTITY	The role of NAD -LRB- P -RRB- H : quinone reductase -LRB- EC 1.6.99.2 , DT-diaphorase -RRB- in the reductive bioactivation of the novel indoloquinone antitumor agent EO9 .
1737339	0	quinone	8,15	DT-diaphorase	126,139	quinone	DT-diaphorase	MESH:C004532	1728	Chemical	Gene	expression|amod|START_ENTITY expression|dep|characterization characterization|nmod|mutation mutation|acl:relcl|modulates modulates|dobj|activity activity|amod|END_ENTITY	NAD -LRB- P -RRB- H : quinone oxidoreductase gene expression in human colon_carcinoma cells : characterization of a mutation which modulates DT-diaphorase activity and mitomycin sensitivity .
1908440	0	quinone	8,15	DT-diaphorase	32,45	quinone	DT-diaphorase	MESH:C004532	18104(Tax:10090)	Chemical	Gene	activity|amod|START_ENTITY activity|amod|oxidoreductase oxidoreductase|dep|END_ENTITY	NAD -LRB- P -RRB- H : quinone oxidoreductase -LRB- DT-diaphorase -RRB- activity and mRNA content in normal and neoplastic_mouse_lung_epithelia .
2105732	0	quinone	9,16	DT-diaphorase	33,46	quinone	DT-diaphorase	MESH:C004532	24314(Tax:10116)	Chemical	Gene	oxidoreductase|amod|START_ENTITY oxidoreductase|appos|END_ENTITY	NAD -LRB- P -RRB- H : quinone oxidoreductase -LRB- DT-diaphorase -RRB- in chick embryo liver .
2121335	0	quinone	37,44	DT-diaphorase	71,84	quinone	DT-diaphorase	MESH:C004532	1728	Chemical	Gene	oxidoreductase|amod|START_ENTITY oxidoreductase|appos|END_ENTITY	Metabolism of diaziquone by NAD -LRB- P -RRB- H : -LRB- quinone acceptor -RRB- oxidoreductase -LRB- DT-diaphorase -RRB- : role in diaziquone-induced DNA damage and cytotoxicity in human colon_carcinoma cells .
2499768	0	quinone	45,52	DT-diaphorase	22,35	quinone	DT-diaphorase	MESH:C004532	24314(Tax:10116)	Chemical	Gene	reductase|amod|START_ENTITY H|dep|reductase NAD|dep|H END_ENTITY|appos|NAD	Reaction of rat liver DT-diaphorase -LRB- NAD -LRB- P -RRB- H : quinone acceptor reductase -RRB- with 5 ' - -LSB- p - -LRB- fluorosulfonyl -RRB- benzoyl -RSB- - adenosine .
3089219	0	quinone	46,53	DT-diaphorase	23,36	quinone	DT-diaphorase	MESH:C004532	1728	Chemical	Gene	dehydrogenase|amod|START_ENTITY H|dep|dehydrogenase NAD|dep|H END_ENTITY|appos|NAD	Lapachol inhibition of DT-diaphorase -LRB- NAD -LRB- P -RRB- H : quinone dehydrogenase -RRB- .
6191666	0	quinone	147,154	DT-diaphorase	166,179	quinone	DT-diaphorase	MESH:C004532	24314(Tax:10116)	Chemical	Gene	reductase|amod|START_ENTITY reductase|appos|END_ENTITY	Hepatic low-level chemiluminescence during redox cycling of menadione and the menadione-glutathione conjugate : relation to glutathione and NAD -LRB- P -RRB- H : quinone reductase -LRB- DT-diaphorase -RRB- activity .
7565631	0	quinone	135,142	DT-diaphorase	71,84	quinone	DT-diaphorase	MESH:C004532	1728	Chemical	Gene	cytotoxicity|amod|START_ENTITY _|dep|cytotoxicity _|dep|oxidoreductase oxidoreductase|appos|END_ENTITY	Nicotinamide_adenine_dinucleotide _ -LRB- phosphate -RRB- : quinone oxidoreductase -LRB- DT-diaphorase -RRB- as a target for bioreductive antitumor quinones : quinone cytotoxicity and selectivity in human lung and breast_cancer cell lines .
7565631	0	quinone	47,54	DT-diaphorase	71,84	quinone	DT-diaphorase	MESH:C004532	1728	Chemical	Gene	oxidoreductase|amod|START_ENTITY oxidoreductase|appos|END_ENTITY	Nicotinamide_adenine_dinucleotide _ -LRB- phosphate -RRB- : quinone oxidoreductase -LRB- DT-diaphorase -RRB- as a target for bioreductive antitumor quinones : quinone cytotoxicity and selectivity in human lung and breast_cancer cell lines .
7620214	0	quinone	127,134	DT-diaphorase	200,213	quinone	DT-diaphorase	MESH:C004532	1728	Chemical	Gene	agents|amod|START_ENTITY emphasis|nmod|agents emphasis|amod|END_ENTITY	Enzyme-directed bioreductive drug development revisited : a commentary on recent progress and future prospects with emphasis on quinone anticancer agents and quinone metabolizing enzymes , particularly DT-diaphorase .
7653992	0	quinone	100,107	DT-diaphorase	19,32	quinone	DT-diaphorase	MESH:C004532	18104(Tax:10090)	Chemical	Gene	sensitivity|compound|START_ENTITY lead|nmod|sensitivity lead|nsubj|Over-expression Over-expression|nmod|END_ENTITY	Over-expression of DT-diaphorase in transfected NIH 3T3 cells does not lead to increased anticancer quinone drug sensitivity : a questionable role for the enzyme as a target for bioreductively activated anticancer drugs .
7780966	0	quinone	89,96	DT-diaphorase	39,52	quinone	DT-diaphorase	MESH:C004532	1728	Chemical	Gene	site|amod|START_ENTITY present|nsubj|site lacking|ccomp|present RNA|xcomp|lacking RNA|nsubj|form form|nmod|messenger messenger|appos|END_ENTITY	An alternatively spliced form of NQO1 -LRB- DT-diaphorase -RRB- messenger RNA lacking the putative quinone substrate binding site is present in human normal and tumor tissues .
7857313	0	quinone	54,61	DT-diaphorase	78,91	quinone	DT-diaphorase	MESH:C004532	1728	Chemical	Gene	oxidoreductase|amod|START_ENTITY oxidoreductase|appos|END_ENTITY	Involvement of NF-kappa_B in the induction of NAD -LRB- P -RRB- H : quinone oxidoreductase -LRB- DT-diaphorase -RRB- by hypoxia , oltipraz and mitomycin_C .
8403076	0	quinone	42,49	DT-diaphorase	142,155	quinone	DT-diaphorase	MESH:C004532	1728	Chemical	Gene	agents|amod|START_ENTITY formation|nmod|agents comparison|nmod|formation oxidoreductase|nsubj|comparison oxidoreductase|dep|END_ENTITY	A comparison of free radical formation by quinone antitumour agents in MCF-7 cells and the role of NAD -LRB- P -RRB- H -LRB- quinone-acceptor -RRB- oxidoreductase -LRB- DT-diaphorase -RRB- .
8461317	0	quinone	18,25	DT-diaphorase	37,50	quinone	DT-diaphorase	MESH:C004532	24314(Tax:10116)	Chemical	Gene	reductase|amod|START_ENTITY reductase|appos|END_ENTITY	Does lung NAD -LRB- P -RRB- H : quinone reductase -LRB- DT-diaphorase -RRB- play an antioxidant enzyme role in protection from hyperoxia ?
8615901	0	quinone	16,23	DT-diaphorase	40,53	quinone	DT-diaphorase	MESH:C004532	1728	Chemical	Gene	oxidoreductase|amod|START_ENTITY oxidoreductase|appos|END_ENTITY	Role of NAD -LRB- P -RRB- H : quinone oxidoreductase -LRB- DT-diaphorase -RRB- in cytotoxicity and induction of DNA damage by streptonigrin .
8863816	0	quinone	29,36	DT-diaphorase	53,66	quinone	DT-diaphorase	MESH:C004532	1728	Chemical	Gene	oxidoreductase|amod|START_ENTITY oxidoreductase|appos|END_ENTITY	Expression of human NAD -LRB- P -RRB- H : quinone oxidoreductase -LRB- DT-diaphorase -RRB- in Chinese_hamster ovary cells : effect on the toxicity of antitumor quinones .
9000600	0	quinone	47,54	DT-diaphorase	71,84	quinone	DT-diaphorase	MESH:C004532	1728	Chemical	Gene	oxidoreductase|amod|START_ENTITY oxidoreductase|appos|END_ENTITY	Characterization of a polymorphism in NAD -LRB- P -RRB- H : quinone oxidoreductase -LRB- DT-diaphorase -RRB- .
10383895	0	quinone	23,30	NQO1	47,51	quinone	NQO1	MESH:C004532	1728	Chemical	Gene	oxidoreductase|amod|START_ENTITY oxidoreductase|appos|END_ENTITY	Association of NAD -LRB- P -RRB- H : quinone oxidoreductase -LRB- NQO1 -RRB- null with numbers of basal_cell_carcinomas : use of a multivariate model to rank the relative importance of this polymorphism and those at other relevant loci .
11156173	0	quinone	22,29	NQO1	46,50	quinone	NQO1	MESH:C004532	1728	Chemical	Gene	oxidoreductase|amod|START_ENTITY oxidoreductase|dep|END_ENTITY	Modulation of Nad -LRB- P -RRB- H : quinone oxidoreductase -LRB- NQO1 -RRB- activity mediated by 5-arylamino-2-methyl-4 ,7 - dioxobenzothiazoles and their cytotoxic potential .
11693537	0	quinone	103,110	NQO1	127,131	quinone	NQO1	MESH:C004532	1728	Chemical	Gene	activity|advmod|START_ENTITY activity|appos|END_ENTITY	Effects of 6-arylamino-5 ,8 - quinolinediones and 6-chloro-7-arylamino-5 ,8 - isoquinolinediones on NAD -LRB- P -RRB- H : quinone oxidoreductase -LRB- NQO1 -RRB- activity and their cytotoxic potential .
11710826	0	quinone	35,42	NQO1	21,25	quinone	NQO1	MESH:C004532	1728	Chemical	Gene	oxidoreductase|amod|START_ENTITY H|dep|oxidoreductase strategy|dep|H strategy|nmod|END_ENTITY	A novel strategy for NQO1 -LRB- NAD -LRB- P -RRB- H : quinone oxidoreductase , EC 1.6.99.2 -RRB- mediated therapy of bladder_cancer based on the pharmacological properties of EO9 .
11882782	0	quinone	8,15	NQO1	32,36	quinone	NQO1	MESH:C004532	1728	Chemical	Gene	START_ENTITY|dobj|polymorphism polymorphism|appos|END_ENTITY	NAD -LRB- P -RRB- H : quinone oxidoreductase -LRB- NQO1 -RRB- polymorphism , exposure to benzene , and predisposition to disease : a HuGE review .
11943609	0	quinone	136,143	NQO1	160,164	quinone	NQO1	MESH:C004532	1728	Chemical	Gene	oxidoreductase|amod|START_ENTITY oxidoreductase|appos|END_ENTITY	Analyses of bulky DNA adduct levels in human breast tissue and genetic polymorphisms of cytochromes P450 -LRB- CYPs -RRB- , myeloperoxidase -LRB- MPO -RRB- , quinone oxidoreductase -LRB- NQO1 -RRB- , and glutathione_S-transferases -LRB- GSTs -RRB- .
12429349	0	quinone	85,92	NQO1	109,113	quinone	NQO1	MESH:C004532	1728	Chemical	Gene	oxidoreductase|amod|START_ENTITY oxidoreductase|appos|END_ENTITY	A physiological threshold for protection against menadione toxicity by human NAD -LRB- P -RRB- H : quinone oxidoreductase -LRB- NQO1 -RRB- in Chinese_hamster_ovary -LRB- CHO -RRB- cells .
12649308	0	quinone	20,27	NQO1	46,50	quinone	NQO1	MESH:C004532	18104(Tax:10090)	Chemical	Gene	I|amod|START_ENTITY I|appos|END_ENTITY	Kinetics of NAD -LRB- P -RRB- H : quinone oxidoreductase I -LRB- NQO1 -RRB- inhibition by mitomycin_C in vitro and in vivo .
12834817	0	quinone	9,16	NQO1	33,37	quinone	NQO1	MESH:C004532	1728	Chemical	Gene	oxidoreductase|amod|START_ENTITY oxidoreductase|appos|END_ENTITY	NAD -LRB- P -RRB- H : quinone oxidoreductase -LRB- NQO1 -RRB- gene polymorphism and schizophrenia .
12849725	0	quinone	12,19	NQO1	31,35	quinone	NQO1	MESH:C004532	1728	Chemical	Gene	role|nmod|START_ENTITY reductase|nsubj|role reductase|dep|END_ENTITY	The role of quinone reductase -LRB- NQO1 -RRB- and quinone chemistry in quercetin cytotoxicity .
15298951	0	quinone	71,78	NQO1	93,97	quinone	NQO1	MESH:C004532	1728	Chemical	Gene	oxoreductase|amod|START_ENTITY oxoreductase|appos|END_ENTITY	Oral contraceptive use and breast_cancer risk : modification by NAD -LRB- P -RRB- H : quinone oxoreductase -LRB- NQO1 -RRB- genetic polymorphisms .
15746574	0	quinone	29,36	NQO1	62,66	quinone	NQO1	MESH:C004532	1728	Chemical	Gene	oxidoreductase|amod|START_ENTITY oxidoreductase|appos|END_ENTITY	Cytotoxicity of RH1 : NAD -LRB- P -RRB- H : quinone acceptor oxidoreductase -LRB- NQO1 -RRB- - independent oxidative stress and apoptosis induction .
16003741	0	quinone	18,25	NQO1	42,46	quinone	NQO1	MESH:C004532	1728	Chemical	Gene	oxidoreductase|amod|START_ENTITY oxidoreductase|appos|END_ENTITY	Targeting NAD -LRB- P -RRB- H : quinone oxidoreductase -LRB- NQO1 -RRB- in pancreatic_cancer .
16678022	1	quinone	107,114	NQO1	132,136	quinone	NQO2	MESH:C004532	18105(Tax:10090)	Chemical	Gene	oxidoreductases|amod|START_ENTITY oxidoreductases|appos|END_ENTITY	NAD -LRB- P -RRB- H/NRH : quinone oxidoreductases -LRB- NQO1 and NQO2 -RRB- protect against oxidative stress and neoplasia .
17305492	0	quinone	81,88	NQO1	67,71	quinone	NQO1	MESH:C004532	24314(Tax:10116)	Chemical	Gene	reduction|amod|START_ENTITY mediated|dobj|reduction mediated|nsubj|END_ENTITY	Identification of a novel intestinal first pass metabolic pathway : NQO1 mediated quinone reduction and subsequent glucuronidation .
18444152	0	quinone	82,89	NQO1	106,110	quinone	NQO1	MESH:C004532	1728	Chemical	Gene	oxidoreductase|amod|START_ENTITY oxidoreductase|appos|END_ENTITY	The influence of fruit and vegetable consumption and genetic variation on NAD -LRB- P -RRB- H : quinone oxidoreductase -LRB- NQO1 -RRB- phenotype in an endoscopy-based population .
18813798	0	quinone	53,60	NQO1	71,75	quinone	NQO1	MESH:C004532	1728	Chemical	Gene	status|nmod|START_ENTITY Control|nmod|status reductase|nsubj|Control reductase|dobj|END_ENTITY	Control of cellular redox status and upregulation of quinone reductase NQO1 via Nrf2 activation by alpha-lipoic_acid in human leukemia HL-60 cells .
19536870	0	quinone	93,100	NQO1	117,121	quinone	NQO1	MESH:C004532	1728	Chemical	Gene	oxidoreductase|amod|START_ENTITY oxidoreductase|appos|END_ENTITY	The aliphatic isothiocyanates erucin and sulforaphane do not effectively up-regulate NAD -LRB- P -RRB- H : quinone oxidoreductase -LRB- NQO1 -RRB- in human liver compared with rat .
19657853	0	quinone	43,50	NQO1	129,133	quinone	NQO1	MESH:C004532	1728	Chemical	Gene	oxidoreductase|amod|START_ENTITY expression|dep|oxidoreductase expression|nmod|activity activity|compound|END_ENTITY	Heat_shock increases expression of NAD -LRB- P -RRB- H : quinone oxidoreductase -LRB- NQO1 -RRB- , mediator of beta-lapachone cytotoxicity , by increasing NQO1 gene activity and via Hsp70-mediated stabilisation of NQO1 protein .
19657853	0	quinone	43,50	NQO1	67,71	quinone	NQO1	MESH:C004532	1728	Chemical	Gene	oxidoreductase|amod|START_ENTITY oxidoreductase|appos|END_ENTITY	Heat_shock increases expression of NAD -LRB- P -RRB- H : quinone oxidoreductase -LRB- NQO1 -RRB- , mediator of beta-lapachone cytotoxicity , by increasing NQO1 gene activity and via Hsp70-mediated stabilisation of NQO1 protein .
20036559	0	quinone	50,57	NQO1	74,78	quinone	NQO1	MESH:C004532	1728	Chemical	Gene	inhibitors|nmod|START_ENTITY Triazoloacridin-6-ones|nmod|inhibitors oxidoreductases|nsubj|Triazoloacridin-6-ones oxidoreductases|dobj|END_ENTITY	Triazoloacridin-6-ones as novel inhibitors of the quinone oxidoreductases NQO1 and NQO2 .
20391128	0	quinone	13,20	NQO1	39,43	quinone	NQO1	MESH:C004532	1728	Chemical	Gene	Detection|nmod|START_ENTITY oxidoreductase|nsubj|Detection oxidoreductase|xcomp|polymorphisms polymorphisms|nsubj|1 1|appos|END_ENTITY	Detection of quinone oxidoreductase 1 -LRB- NQO1 -RRB- single-nucleotide polymorphisms -LRB- SNP -RRB- related to benzene metabolism in immortalized B lymphocytes from a Chinese Han population .
23746950	0	quinone	88,95	NQO1	112,116	quinone	NQO1	MESH:C004532	1728	Chemical	Gene	induction|nmod|START_ENTITY b-Lapachone|nmod|induction oxidoreductase|amod|b-Lapachone oxidoreductase|appos|END_ENTITY	Synergistic enhancement of antitumor effect of b-Lapachone by photodynamic induction of quinone oxidoreductase -LRB- NQO1 -RRB- .
23883585	2	quinone	395,402	NQO1	419,423	quinone	Her2	MESH:C004532	2064	Chemical	Gene	oxidoreductase|amod|START_ENTITY oxidoreductase|appos|END_ENTITY	b-Lapachone -LRB- clinical forms , Arq501/Arq761 -RRB- has been developed to exploit dramatic cancer-specific elevations in the phase II detoxifying enzyme NAD -LRB- P -RRB- H : quinone oxidoreductase -LRB- NQO1 -RRB- .
24015818	0	quinone	52,59	NQO1	78,82	quinone	NQO1	MESH:C004532	18104(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|oxidoreductase oxidoreductase|appos|END_ENTITY	Assessment of the contribution of NAD -LRB- P -RRB- H-dependent quinone oxidoreductase 1 -LRB- NQO1 -RRB- to the reduction of vitamin_K in wild-type and NQO1-deficient mice .
7780966	0	quinone	89,96	NQO1	33,37	quinone	NQO1	MESH:C004532	1728	Chemical	Gene	site|amod|START_ENTITY present|nsubj|site lacking|ccomp|present RNA|xcomp|lacking RNA|nsubj|form form|nmod|messenger messenger|compound|END_ENTITY	An alternatively spliced form of NQO1 -LRB- DT-diaphorase -RRB- messenger RNA lacking the putative quinone substrate binding site is present in human normal and tumor tissues .
9012471	0	quinone	110,117	NQO1	134,138	quinone	NQO1	MESH:C004532	1728	Chemical	Gene	oxidoreductase|amod|START_ENTITY oxidoreductase|appos|END_ENTITY	Caffeic_acid_phenethyl_ester stimulates human antioxidant response element-mediated expression of the NAD -LRB- P -RRB- H : quinone oxidoreductase -LRB- NQO1 -RRB- gene .
9871615	0	quinone	53,60	NQO1	115,119	quinone	NQO1	MESH:C004532	1728	Chemical	Gene	structure|amod|START_ENTITY relationship|nmod|structure relationship|nmod|metabolism metabolism|nmod|END_ENTITY	Indolequinone antitumor agents : relationship between quinone structure and rate of metabolism by recombinant human NQO1 .
21742892	0	quinone	72,79	oxidoreductase	80,94	quinone	oxidoreductase	MESH:C004532	7296	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	KefF , the regulatory subunit of the potassium efflux system KefC , shows quinone oxidoreductase activity .
18007403	0	quinoxaline	29,40	JSP-1	41,46	quinoxaline	JSP-1	CHEBI:36616	56940	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Preparation of 6-substituted quinoxaline JSP-1 inhibitors by microwave accelerated nucleophilic substitution .
2566488	0	quinpirole	31,41	D-2	19,22	quinpirole	D-2	MESH:D019257	29484(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|agonist agonist|compound|END_ENTITY	Biphasic effect of D-2 agonist quinpirole on locomotion and movements .
9401747	0	quinpirole	36,46	Fos	63,66	quinpirole	Fos	MESH:D019257	314322(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Compartmentally specific effects of quinpirole on the striatal Fos expression induced by stimulation of D1-dopamine receptors in intact rats .
12827645	0	quinpirole	87,97	catecholamine-regulated_protein	27,58	quinpirole	catecholamine-regulated protein	MESH:D019257	291671(Tax:10116)	Chemical	Gene	administration|amod|START_ENTITY END_ENTITY|nmod|administration	Asymmetric modulation of a catecholamine-regulated_protein in the rat brain , following quinpirole administration .
8100980	0	quinpirole_hydrochloride	42,66	prolactin	114,123	quinpirole hydrochloride	prolactin	MESH:D019257	24683(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The stimulatory and inhibitory effects of quinpirole_hydrochloride , D2-dopamine receptor agonist , on secretion of prolactin as assessed by the reverse hemolytic plaque assay .
15848758	0	quipazine	81,90	serotonin_transporter	94,115	quipazine	serotonin transporter	MESH:D011814	6532	Chemical	Gene	START_ENTITY|nmod|ligands ligands|compound|END_ENTITY	Structure-affinity relationship studies on arylpiperazine derivatives related to quipazine as serotonin_transporter ligands .
24038993	0	quisinostat	64,75	histone_deacetylase	33,52	quisinostat	histone deacetylase	null	9734	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Initial testing -LRB- stage 1 -RRB- of the histone_deacetylase inhibitor , quisinostat -LRB- JNJ-26481585 -RRB- , by the Pediatric Preclinical Testing Program .
1791975	0	quisqualate	15,26	MAP2	65,69	quisqualate	MAP2	MESH:D016318	4133	Chemical	Gene	START_ENTITY|nmod|organization organization|nmod|END_ENTITY	The effects of quisqualate and nocodazole on the organization of MAP2 and neurofilaments in spinal cord neurons in vitro .
1848014	0	quisqualate	74,85	phospholipase_A2	99,115	quisqualate	phospholipase A2	MESH:D016318	151056	Chemical	Gene	receptors|amod|START_ENTITY receptors|nmod|END_ENTITY	Modulation of DL-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic_acid / quisqualate receptors by phospholipase_A2 : a necessary step in long-term potentiation ?
8971923	0	quisqualic_acid	87,102	alpha-MSH	10,19	quisqualic acid	alpha-MSH	MESH:D016318	5443	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of alpha-MSH upon cyclic_AMP levels induced by the glutamatergic agonists NMDA , quisqualic_acid , and kainic_acid .
23967177	0	quizartinib	19,30	ABCG2	40,45	quizartinib	ABCG2	MESH:C544967	9429	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	The FLT3 inhibitor quizartinib inhibits ABCG2 at pharmacologically relevant concentrations , with implications for both chemosensitization and adverse drug interactions .
1428205	0	r-HuEPO	44,51	erythropoietin	28,42	r-HuEPO	erythropoietin	null	2056	Chemical	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of recombinant human erythropoietin -LRB- r-HuEPO -RRB- therapy on plasma FT3 , FT4 , TSH , FSH , LH , free testosterone and prolactin levels in hemodialysis patients .
9495304	0	r-hirudin	67,76	thrombin	42,50	r-hirudin	thrombin	null	100144442(Tax:9823)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Dissolution of mural_thrombus by specific thrombin inhibition with r-hirudin : comparison with heparin and aspirin .
25082758	0	rGO	66,69	SnO	59,62	rGO	SnO	null	55206	Chemical	Gene	aerogel|compound|START_ENTITY aerogel|compound|END_ENTITY	Novel and facile method , dynamic self-assemble , to prepare SnO / rGO droplet aerogel with complex morphologies and their application in supercapacitors .
11346713	1	rHu-Epo	154,161	erythropoietin	138,152	rHu-Epo	erythropoietin	null	2056	Chemical	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Synergic effect with DNA recombinant erythropoietin -LRB- rHu-Epo -RRB- -RSB- .
15024187	0	rHuKGF	56,62	keratinocyte_growth_factor	28,54	rHuKGF	keratinocyte growth factor	null	2252	Chemical	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of recombinant human keratinocyte_growth_factor -LRB- rHuKGF -RRB- on the immunopathogenesis of intestinal graft-vs .
11736724	0	rabeprazole	220,231	CYP2C19	11,18	rabeprazole	CYP2C19	MESH:C063129	1557	Chemical	Gene	reduced|nsubjpass|START_ENTITY metabolized|advcl|reduced BACKGROUND|parataxis|metabolized BACKGROUND|nsubj|Effects Effects|nmod|differences differences|nummod|END_ENTITY	Effects of CYP2C19 genotypic differences in the metabolism of omeprazole and rabeprazole on intragastric pH. BACKGROUND : Omeprazole is mainly metabolized in the liver by CYP2C19 , a genetically determined enzyme , whereas rabeprazole is mainly reduced non-enzymatically and partially metabolized by CYP2C19 .
15715938	0	rabeprazole	51,62	CYP2C19	78,85	rabeprazole	CYP2C19	MESH:C063129	1557	Chemical	Gene	START_ENTITY|nmod|relation relation|nmod|END_ENTITY	Pharmacodynamic effects and kinetic disposition of rabeprazole in relation to CYP2C19 genotype in healthy Chinese subjects .
16012079	0	rabeprazole	46,57	CYP2C19	117,124	rabeprazole	CYP2C19	MESH:C063129	1557	Chemical	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|recipients recipients|acl:relcl|END_ENTITY	Comparison of enantioselective disposition of rabeprazole versus lansoprazole in renal-transplant recipients who are CYP2C19 extensive metabolizers .
16359346	0	rabeprazole	40,51	CYP2C19	0,7	rabeprazole	CYP2C19	MESH:C063129	1557	Chemical	Gene	focus|nmod|START_ENTITY genotype|dep|focus genotype|nummod|END_ENTITY	CYP2C19 genotype and the PPIs -- focus on rabeprazole .
16487224	0	rabeprazole	36,47	CYP2C19	80,87	rabeprazole	CYP2C19	MESH:C063129	1557	Chemical	Gene	fluvoxamine|nmod|START_ENTITY effects|nmod|fluvoxamine pharmacokinetics|nsubj|effects pharmacokinetics|nmod|status status|compound|END_ENTITY	Different effects of fluvoxamine on rabeprazole pharmacokinetics in relation to CYP2C19 genotype status .
16487225	0	rabeprazole	32,43	CYP2C19	59,66	rabeprazole	CYP2C19	MESH:C063129	1557	Chemical	Gene	START_ENTITY|nmod|relation relation|nmod|END_ENTITY	Enantioselective disposition of rabeprazole in relation to CYP2C19 genotypes .
16783561	0	rabeprazole	43,54	CYP2C19	80,87	rabeprazole	CYP2C19	MESH:C063129	1557	Chemical	Gene	pharmacokinetics|amod|START_ENTITY Effects|nmod|pharmacokinetics Effects|nmod|genotypes genotypes|nummod|END_ENTITY	Effects of clarithromycin and verapamil on rabeprazole pharmacokinetics between CYP2C19 genotypes .
16911688	0	rabeprazole	33,44	CYP2C19	108,115	rabeprazole	CYP2C19	MESH:C063129	1557	Chemical	Gene	administration|amod|START_ENTITY effects|nmod|administration influenced|nsubjpass|effects influenced|nmod|polymorphism polymorphism|compound|END_ENTITY	Therapeutic effects of 10 mg/day rabeprazole administration on reflux_esophagitis was not influenced by the CYP2C19 polymorphism .
16937451	0	rabeprazole	38,49	CYP2C19	88,95	rabeprazole	CYP2C19	MESH:C063129	1557	Chemical	Gene	effect|nmod|START_ENTITY level|nsubj|effect level|nmod|polymorphism polymorphism|compound|END_ENTITY	Pharmacodynamic and kinetic effect of rabeprazole on serum gastrin level in relation to CYP2C19 polymorphism in Chinese Hans .
17377957	0	rabeprazole	13,24	CYP2C19	95,102	rabeprazole	CYP2C19	MESH:C063129	1557	Chemical	Gene	START_ENTITY|nmod|pharmacokinetics pharmacokinetics|nmod|tacrolimus tacrolimus|nmod|relation relation|nmod|END_ENTITY	Influence of rabeprazole and lansoprazole on the pharmacokinetics of tacrolimus in relation to CYP2C19 , CYP3A5 and MDR1 polymorphisms in renal transplant recipients .
20838991	0	rabeprazole	83,94	CYP2C19	10,17	rabeprazole	CYP2C19	MESH:C063129	1557	Chemical	Gene	relationship|nmod|START_ENTITY genotypes|nmod|relationship genotypes|nsubj|Effect Effect|nmod|END_ENTITY	Effect of CYP2C19 genotypes on the pharmacokinetic/pharmacodynamic relationship of rabeprazole after a single oral dose in healthy Chinese volunteers .
22108775	0	rabeprazole	31,42	CYP2C19	181,188	rabeprazole	CYP2C19	MESH:C063129	1557	Chemical	Gene	relationships|nmod|START_ENTITY mg|nsubj|relationships mg|nmod|genotypes genotypes|compound|END_ENTITY	Dose-response relationships of rabeprazole 5 , 10 , 20 , and 40 mg once daily on suppression of gastric_acid secretion through the night in healthy Japanese individuals with different CYP2C19 genotypes .
22542748	0	rabeprazole	11,22	CYP2C19	110,117	rabeprazole	CYP2C19	MESH:C063129	1557	Chemical	Gene	Ability|nmod|START_ENTITY depends|nsubj|Ability depends|nmod|genotype genotype|compound|END_ENTITY	Ability of rabeprazole to prevent gastric_mucosal_damage from clopidogrel and low doses of aspirin depends on CYP2C19 genotype .
22882464	0	rabeprazole	85,96	CYP2C19	134,141	rabeprazole	CYP2C19	MESH:C063129	1557	Chemical	Gene	b.d.|compound|START_ENTITY decreases|nmod|b.d. decreases|advcl|overcoming overcoming|dobj|genotype genotype|compound|END_ENTITY	Rabeprazole 10 mg q.d.s. decreases 24-h intragastric acidity significantly more than rabeprazole 20 mg b.d. or 40 mg o.m. , overcoming CYP2C19 genotype .
23474843	0	rabeprazole	30,41	CYP2C19	0,7	rabeprazole	CYP2C19	MESH:C063129	1557	Chemical	Gene	polymorphism|amod|START_ENTITY polymorphism|nummod|END_ENTITY	CYP2C19 genetic polymorphism , rabeprazole and esomeprazole have no effect on the antiplatelet action of clopidogrel .
26427705	0	rabeprazole	41,52	CYP2C19	161,168	rabeprazole	CYP2C19	MESH:C063129	1557	Chemical	Gene	doses|nmod|START_ENTITY front-loading|nmod|doses provides|nsubj|front-loading provides|dobj|inhibition inhibition|nmod|metabolizers metabolizers|nmod|END_ENTITY	One-day front-loading with four doses of rabeprazole followed by a standard twice-daily regimen provides sufficient acid inhibition in extensive metabolizers of CYP2C19 .
20143290	0	racecadotril	30,42	enkephalinase	60,73	racecadotril	enkephalinase	MESH:C049331	24590(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Increase of plasma insulin by racecadotril , an inhibitor of enkephalinase , in Wistar_rats .
21557151	0	racecadotril	42,54	insulin_degrading_enzyme	14,38	racecadotril	insulin degrading enzyme	MESH:C049331	25700(Tax:10116)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of insulin_degrading_enzyme by racecadotril in the brain of Wistar_rats .
17200836	0	racemate	98,106	CYP3A4	14,20	racemate	CYP3A4	CHEBI:60911	1576	Chemical	Gene	catalyzed|nmod|START_ENTITY catalyzed|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of CYP3A4 and CYP3A5 catalyzed metabolism of alprazolam and quinine by ketoconazole as racemate and four different enantiomers .
22290999	0	raclopride	76,86	D-2	90,93	raclopride	D-2	MESH:D020891	28503	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Effect of chronic treatment with NNC_756 , a new D-1 receptor antagonist , or raclopride , a D-2 receptor antagonist , in drug-naive Cebus monkeys : dystonia , dyskinesia and D-1 / D-2 supersensitivity .
15962764	0	radicicol	59,68	Heat_shock_protein_90	0,21	radicicol	Heat shock protein 90	MESH:C035359	3320	Chemical	Gene	inhibitor|appos|START_ENTITY potentiated|nsubj|inhibitor chaperone|ccomp|potentiated chaperone|nsubj|END_ENTITY	Heat_shock_protein_90 -LRB- Hsp90 -RRB- chaperone complex inhibitor , radicicol , potentiated radiation-induced cell killing in a_hormone-sensitive_prostate_cancer cell line through degradation of the androgen_receptor .
10383157	0	radicicol	37,46	Hsp90	111,116	radicicol	Hsp90	MESH:C035359	3320	Chemical	Gene	derivative|nmod|START_ENTITY KF25706|appos|derivative exhibits|nsubj|KF25706 exhibits|nmod|activity activity|nmod|depletion depletion|nmod|molecules molecules|amod|END_ENTITY	KF25706 , a novel oxime derivative of radicicol , exhibits in vivo antitumor activity via selective depletion of Hsp90 binding signaling molecules .
10979978	0	radicicol	27,36	Hsp90	206,211	radicicol	Hsp90	MESH:C035359	3320	Chemical	Gene	induce|amod|START_ENTITY derivatives|nmod|induce erythroid|nsubj|derivatives erythroid|nmod|complex complex|amod|END_ENTITY	Novel oxime derivatives of radicicol induce erythroid differentiation associated with preferential G -LRB- 1 -RRB- phase accumulation against chronic_myelogenous_leukemia cells through destabilization of Bcr-Abl with Hsp90 complex .
15962764	0	radicicol	59,68	Hsp90	23,28	radicicol	Hsp90	MESH:C035359	3320	Chemical	Gene	inhibitor|appos|START_ENTITY potentiated|nsubj|inhibitor chaperone|ccomp|potentiated chaperone|nsubj|Heat_shock_protein_90 Heat_shock_protein_90|appos|END_ENTITY	Heat_shock_protein_90 -LRB- Hsp90 -RRB- chaperone complex inhibitor , radicicol , potentiated radiation-induced cell killing in a_hormone-sensitive_prostate_cancer cell line through degradation of the androgen_receptor .
16499313	0	radicicol	93,102	Hsp90	11,16	radicicol	Hsp90	MESH:C035359	855836(Tax:4932)	Chemical	Gene	studies|nmod|START_ENTITY inhibitors|dep|studies inhibitors|amod|END_ENTITY	Search for Hsp90 inhibitors with potential anticancer activity : isolation and SAR studies of radicicol and monocillin_I from two plant-associated fungi of the Sonoran desert .
19101477	0	radicicol	51,60	Hsp90	65,70	radicicol	Hsp90	MESH:C035359	3320	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Functional characterization of the biosynthesis of radicicol , an Hsp90 inhibitor resorcylic_acid_lactone from Chaetomium chiversii .
19582223	0	radicicol	99,108	Hsp90	120,125	radicicol	Hsp90	MESH:C035359	3320	Chemical	Gene	binding|amod|START_ENTITY binding|nmod|END_ENTITY	Measurement of nanomolar_dissociation constants by titration calorimetry and thermal_shift_assay - radicicol binding to Hsp90 and ethoxzolamide binding to CAII .
9672245	0	radicicol	11,20	Hsp90	55,60	radicicol	Hsp90	MESH:C035359	3320	Chemical	Gene	binds|nsubj|START_ENTITY binds|nmod|domain domain|nmod|END_ENTITY	Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin .
11562079	0	radicicol	39,48	IL-8	15,19	radicicol	IL-8	MESH:C035359	3576	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Suppression of IL-8 gene expression by radicicol is mediated through the inhibition of ERK1/2 and p38 signaling and negative regulation of NF-kappaB and AP-1 .
19236053	0	radicicol	24,33	hsp90	67,72	radicicol	hsp90	MESH:C035359	855836(Tax:4932)	Chemical	Gene	resistance|amod|START_ENTITY basis|nmod|resistance displayed|nsubj|basis displayed|nmod|END_ENTITY	Structural basis of the radicicol resistance displayed by a fungal hsp90 .
23010732	0	radioactive_iodine	115,133	thyroglobulin	68,81	radioactive iodine	thyroglobulin	null	7038	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of prophylactic central compartment neck dissection on serum thyroglobulin and recommendations for adjuvant radioactive_iodine in patients with differentiated_thyroid_cancer .
22069101	0	radioiodine	81,92	Fibrinogen	0,10	radioiodine	Fibrinogen	null	2244	Chemical	Gene	START_ENTITY|nsubj|levels levels|compound|END_ENTITY	Fibrinogen and D-dimers levels in patients with hyperthyroidism before and after radioiodine therapy .
21737629	0	radioiodine	29,40	thyroglobulin	12,25	radioiodine	thyroglobulin	null	7038	Chemical	Gene	therapy|amod|START_ENTITY END_ENTITY|nmod|therapy	Response of thyroglobulin to radioiodine therapy in thyroglobulin-elevated negative iodine scintigraphy -LRB- TENIS -RRB- syndrome .
23829063	0	radon	129,134	SPA	62,65	radon	SPA	MESH:D011886	729238	Chemical	Gene	concentrations|compound|START_ENTITY information|nmod|concentrations use|advcl|information doses|acl:relcl|use doses|acl|derived derived|nmod|radon radon|nmod|centers centers|compound|END_ENTITY	-LSB- Estimation of effective doses derived from radon in selected SPA centers that use geothermal waters based on the information of radon concentrations -RSB- .
23829063	0	radon	44,49	SPA	62,65	radon	SPA	MESH:D011886	729238	Chemical	Gene	START_ENTITY|nmod|centers centers|compound|END_ENTITY	-LSB- Estimation of effective doses derived from radon in selected SPA centers that use geothermal waters based on the information of radon concentrations -RSB- .
23829063	11	radon	1581,1586	SPA	1604,1607	radon	SPA	MESH:D011886	729238	Chemical	Gene	concentration|compound|START_ENTITY concentration|nmod|facilities facilities|compound|END_ENTITY	CONCLUSIONS : The analysis of radon concentration in SPA facilities shows that the radiological protection of people working with geothermal waters plays an important role .
17203297	0	radon	21,26	spa	27,30	radon	spa	MESH:D011886	729238	Chemical	Gene	therapy|compound|START_ENTITY therapy|compound|END_ENTITY	Long-term benefit of radon spa therapy in the rehabilitation of rheumatoid_arthritis : a randomised , double-blinded trial .
21971209	0	raloxifene	86,96	Adiponectin	0,11	raloxifene	Adiponectin	MESH:D020849	9370	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|levels levels|compound|END_ENTITY	Adiponectin and leptin serum levels in osteoporotic postmenopausal women treated with raloxifene or alendronate .
22707322	0	raloxifene	14,24	Bax	28,31	raloxifene	Bax	MESH:D020849	581	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|compound|END_ENTITY	The effect of raloxifene on Bax protein expression in breast_carcinomas of postmenopausal women .
15807179	0	raloxifene	90,100	Estrogen_receptor	0,17	raloxifene	Estrogen receptor	MESH:D020849	2099	Chemical	Gene	predict|advcl|START_ENTITY predict|nsubj|END_ENTITY	Estrogen_receptor -LRB- ER -RRB- gene polymorphism may predict the bone_mineral_density response to raloxifene in postmenopausal women on chronic hemodialysis .
11747323	0	raloxifene	10,20	IGF-I	24,29	raloxifene	IGF-I	MESH:D020849	3479	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of raloxifene on IGF-I and IGFBP-3 in postmenopausal women with breast_cancer .
24347426	0	raloxifene	11,21	IGF1	48,52	raloxifene	IGF1	MESH:D020849	3479	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of raloxifene and estrogen on bioactive IGF1 in GH-deficient women .
10320515	0	raloxifene	18,28	PTH	66,69	raloxifene	PTH	MESH:D020849	24694(Tax:10116)	Chemical	Gene	analog|amod|START_ENTITY addition|nmod|analog allows|nsubj|addition allows|nmod|END_ENTITY	The addition of a raloxifene analog -LRB- LY117018 -RRB- allows for reduced PTH -LRB- 1-34 -RRB- dosing during reversal of osteopenia in ovariectomized rats .
10321904	0	raloxifene	88,98	PTH	56,59	raloxifene	PTH	MESH:D020849	24694(Tax:10116)	Chemical	Gene	analogue|amod|START_ENTITY Assessment|nmod|analogue Assessment|nmod|END_ENTITY	Assessment of maintenance therapy with reduced doses of PTH -LRB- 1-34 -RRB- in combination with a raloxifene analogue -LRB- LY117018 -RRB- following anabolic therapy in the ovariectomized rat .
17929072	0	raloxifene	28,38	PTH	62,65	raloxifene	PTH	MESH:D020849	5741	Chemical	Gene	START_ENTITY|nmod|response response|nmod|END_ENTITY	Effect of prior and ongoing raloxifene therapy on response to PTH and maintenance of BMD after PTH therapy .
17929072	0	raloxifene	28,38	PTH	95,98	raloxifene	PTH	MESH:D020849	5741	Chemical	Gene	START_ENTITY|nmod|therapy therapy|compound|END_ENTITY	Effect of prior and ongoing raloxifene therapy on response to PTH and maintenance of BMD after PTH therapy .
19371317	0	raloxifene	37,47	UGT1A1	11,17	raloxifene	UGT1A1	MESH:D020849	54658	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of UGT1A1 * 28 polymorphism on raloxifene pharmacokinetics and pharmacodynamics .
15769887	0	raloxifene	55,65	UGT1A10	92,99	raloxifene	UGT1A10	MESH:D020849	54575	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|dep|role role|nmod|END_ENTITY	Species - and disposition model-dependent metabolism of raloxifene in gut and liver : role of UGT1A10 .
17091190	0	raloxifene	11,21	caveolin-1	25,35	raloxifene	caveolin-1	MESH:D020849	857	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|mRNA mRNA|amod|END_ENTITY	Effects of raloxifene on caveolin-1 mRNA and protein expressions in vascular smooth muscle cells .
10485477	0	raloxifene	19,29	estrogen_receptor	108,125	raloxifene	estrogen receptor	MESH:D020849	2099	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	The interaction of raloxifene and the active metabolite of the antiestrogen EM-800 -LRB- SC 5705 -RRB- with the human estrogen_receptor .
17654759	0	raloxifene	113,123	estrogen_receptor	74,91	raloxifene	estrogen receptor	MESH:D020849	2099	Chemical	Gene	modulators|nmod|START_ENTITY modulators|nsubj|relationships relationships|nmod|family family|nmod|END_ENTITY	Structure-activity relationships for a family of benzothiophene selective estrogen_receptor modulators including raloxifene and arzoxifene .
19429434	0	raloxifene	145,155	estrogen_receptor	90,107	raloxifene	estrogen receptor	MESH:D020849	2099	Chemical	Gene	pathways|nmod|START_ENTITY pathways|amod|END_ENTITY	Comparative effects of raloxifene , tamoxifen and estradiol on human osteoblasts in vitro : estrogen_receptor dependent or independent pathways of raloxifene .
19429434	0	raloxifene	23,33	estrogen_receptor	90,107	raloxifene	estrogen receptor	MESH:D020849	2099	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|pathways pathways|amod|END_ENTITY	Comparative effects of raloxifene , tamoxifen and estradiol on human osteoblasts in vitro : estrogen_receptor dependent or independent pathways of raloxifene .
23613312	0	raloxifene	87,97	estrogen_receptor	142,159	raloxifene	estrogen receptor	MESH:D020849	2099	Chemical	Gene	chain|amod|START_ENTITY chain|nmod|ligands ligands|nmod|END_ENTITY	Design , synthesis , and biological evaluation of cyclopropyl analogues of stilbene with raloxifene side chain as subtype-selective ligands for estrogen_receptor .
24930824	0	raloxifene	104,114	estrogen_receptor	33,50	raloxifene	estrogen receptor	MESH:D020849	2099	Chemical	Gene	practice|appos|START_ENTITY modulators|nmod|practice modulators|compound|END_ENTITY	Acquired resistance to selective estrogen_receptor modulators -LRB- SERMs -RRB- in clinical practice -LRB- tamoxifen _ raloxifene -RRB- by selection pressure in breast_cancer cell populations .
9581827	0	raloxifene	43,53	estrogen_receptor	91,108	raloxifene	estrogen receptor	MESH:D020849	2099	Chemical	Gene	mechanism|nmod|START_ENTITY key|nmod|mechanism 351|nsubj|key 351|nmod|END_ENTITY	The key to the antiestrogenic mechanism of raloxifene is amino_acid 351 -LRB- aspartate -RRB- in the estrogen_receptor .
9928564	0	raloxifene	127,137	estrogen_receptor	25,42	raloxifene	estrogen receptor	MESH:D020849	2099	Chemical	Gene	aids|nmod|START_ENTITY aids|nsubj|biology biology|nmod|END_ENTITY	Molecular biology of the estrogen_receptor aids in the understanding of tamoxifen resistance and breast cancer prevention with raloxifene .
21964465	0	raloxifene	37,47	estrogen_receptor_a	14,33	raloxifene	estrogen receptor a	MESH:D020849	2099	Chemical	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	Activation of estrogen_receptor_a by raloxifene through an activating protein-1-dependent tethering mechanism in human cervical epithelial_cancer cells : a role for c-Jun N-terminal kinase .
20207825	0	raloxifene	21,31	growth_hormone	72,86	raloxifene	growth hormone	MESH:D020849	2688	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|action action|nmod|END_ENTITY	Modulatory effect of raloxifene and estrogen on the metabolic action of growth_hormone in hypopituitary women .
17586504	0	raloxifene	11,21	insulin	25,32	raloxifene	insulin	MESH:D020849	3630	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|sensitivity sensitivity|compound|END_ENTITY	Effects of raloxifene on insulin sensitivity , beta-cell function , and hepatic insulin extraction in normal postmenopausal women .
16934544	0	raloxifene	21,31	interleukin-1beta	48,65	raloxifene	interleukin-1beta	MESH:D020849	3553	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|production production|amod|END_ENTITY	Different effects of raloxifene and estrogen on interleukin-1beta and interleukin-1_receptor_antagonist production using in vitro and ex vivo studies .
18560259	0	raloxifene	11,21	osteoprotegerin	45,60	raloxifene	osteoprotegerin	MESH:D020849	4982	Chemical	Gene	therapy|amod|START_ENTITY therapy|acl|circulating circulating|dobj|END_ENTITY	Effects of raloxifene therapy on circulating osteoprotegerin and RANK ligand levels in post-menopausal_osteoporosis .
12370106	0	raloxifene	24,34	prolactin	54,63	raloxifene	prolactin	MESH:D020849	5617	Chemical	Gene	treatment|compound|START_ENTITY treatment|nmod|END_ENTITY	Effects of long-lasting raloxifene treatment on serum prolactin and gonadotropin levels in postmenopausal women .
16775175	0	raloxifene	11,21	prolactin	37,46	raloxifene	prolactin	MESH:D020849	5617	Chemical	Gene	START_ENTITY|acl|circulating circulating|dobj|levels levels|compound|END_ENTITY	Effects of raloxifene on circulating prolactin and estradiol levels in premenopausal women at high risk for developing breast_cancer .
16864147	0	raloxifene	11,21	renin	40,45	raloxifene	renin	MESH:D020849	5972	Chemical	Gene	therapy|amod|START_ENTITY therapy|nmod|END_ENTITY	Effects of raloxifene therapy on plasma renin and aldosterone levels and blood pressure in postmenopausal women .
19489979	0	raloxifene	10,20	vascular_endothelial_growth_factor	24,58	raloxifene	vascular endothelial growth factor	MESH:D020849	7422	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of raloxifene on vascular_endothelial_growth_factor expression in breast_carcinomas of postmenopausal women .
19279563	0	raltegravir	20,31	UGT1A1	52,58	raltegravir	UGT1A1	MESH:C507898	54658	Chemical	Gene	START_ENTITY|nmod|individuals individuals|nmod|END_ENTITY	Pharmacokinetics of raltegravir in individuals with UGT1A1 polymorphisms .
12649388	0	ramatroban	59,69	CRTH2	52,57	ramatroban	CRTH2	MESH:C063119	11251	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|nmod|END_ENTITY	An orally bioavailable small molecule antagonist of CRTH2 , ramatroban -LRB- BAY_u3405 -RRB- , inhibits prostaglandin_D2-induced eosinophil migration in vitro .
9870646	0	ramatroban	14,24	thromboxane_A2_receptor	41,64	ramatroban	thromboxane A2 receptor	MESH:C063119	6915	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|antagonist antagonist|amod|END_ENTITY	The effect of ramatroban -LRB- BAY_u_3405 -RRB- , a thromboxane_A2_receptor antagonist , on nasal cavity volume and minimum cross-sectional area and nasal mucosal hemodynamics after nasal mucosal allergen challenge in patients with perennial_allergic_rhinitis .
10543928	0	ramipril	20,28	ACE	0,3	ramipril	ACE	MESH:D017257	1636	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	ACE inhibition with ramipril improves left ventricular function at rest and post exercise in patients with stable ischaemic_heart_disease and preserved left ventricular systolic function .
11718163	0	ramipril	39,47	ACE	3,6	ramipril	ACE	MESH:D017257	1636	Chemical	Gene	reduces|nsubj|START_ENTITY inhibitor|parataxis|reduces inhibitor|nsubj|END_ENTITY	An ACE inhibitor to coronary patients : ramipril reduces mortality according to HOPE trial .
16398929	0	ramipril	70,78	ACE	54,57	ramipril	ACE	MESH:D017257	1636	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Human physiologically based pharmacokinetic model for ACE inhibitors : ramipril and ramiprilat .
17004100	0	ramipril	98,106	ACE	60,63	ramipril	ACE	MESH:D017257	24310(Tax:10116)	Chemical	Gene	dose|amod|START_ENTITY importance|nmod|dose Mitigation|dep|importance Mitigation|nmod|optic_neuropathy optic_neuropathy|nmod|rats rats|nmod|ramipril ramipril|compound|END_ENTITY	Mitigation of radiation-induced optic_neuropathy in rats by ACE inhibitor ramipril : importance of ramipril dose and treatment time .
1837563	0	ramipril	51,59	ACE	37,40	ramipril	ACE	MESH:D017257	1636	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|inhibitor inhibitor|compound|END_ENTITY	Long lasting arterial effects of the ACE inhibitor ramipril .
25256070	0	ramipril	52,60	ACE	8,11	ramipril	ACE	MESH:D017257	1636	Chemical	Gene	effect|nmod|START_ENTITY polymorphisms|nmod|effect polymorphisms|nsubj|Role Role|nmod|gene gene|compound|END_ENTITY	Role of ACE I/D gene polymorphisms on the effect of ramipril in inflammatory response and myocardial_injury in patients undergoing coronary artery bypass grafts .
9849606	0	ramipril	49,57	ACE	35,38	ramipril	ACE	MESH:D017257	100009274(Tax:9986)	Chemical	Gene	START_ENTITY|nsubj|application application|nmod|inhibitor inhibitor|compound|END_ENTITY	-LSB- Intra-arterial application of the ACE inhibitor ramipril using a microperforated catheter for the prevention of neointimal proliferation after angioplasty in an animal model -RSB- .
9853269	0	ramipril	50,58	ACE	30,33	ramipril	ACE	MESH:D017257	24310(Tax:10116)	Chemical	Gene	rats|amod|START_ENTITY inhibition|nmod|rats inhibition|nsubj|Nephroprotection Nephroprotection|nmod|END_ENTITY	Nephroprotection by long-term ACE inhibition with ramipril in spontaneously hypertensive stroke prone rats .
20970202	0	ramipril	20,28	Ace	113,116	ramipril	Ace	MESH:D017257	1636	Chemical	Gene	trial|nmod|START_ENTITY trial|dep|study study|dep|inhibitors inhibitors|compound|END_ENTITY	Randomised trial of ramipril in repaired tetralogy of Fallot and pulmonary_regurgitation : the APPROPRIATE study -LRB- Ace inhibitors for Potential PRevention Of the deleterious effects of Pulmonary_Regurgitation In Adults with repaired TEtralogy of Fallot -RRB- .
9150805	0	ramipril	84,92	Angiotensin-converting_enzyme	0,29	ramipril	Angiotensin-converting enzyme	MESH:D017257	1636	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY inhibition|dep|pharmacokinetics inhibition|amod|END_ENTITY	Angiotensin-converting_enzyme inhibition in cirrhotic patients -- pharmacokinetics of ramipril .
10933355	0	ramipril	85,93	angiotensin-converting_enzyme	44,73	ramipril	angiotensin-converting enzyme	MESH:D017257	1636	Chemical	Gene	START_ENTITY|nsubj|Randomized Randomized|appos|trial trial|nmod|inhibitor inhibitor|amod|END_ENTITY	Randomized , placebo-controlled trial of the angiotensin-converting_enzyme inhibitor , ramipril , in patients with coronary or other occlusive_arterial_disease .
12423701	0	ramipril	10,18	angiotensin-converting_enzyme	32,61	ramipril	angiotensin-converting enzyme	MESH:D017257	1636	Chemical	Gene	Impact|nmod|START_ENTITY Impact|nmod|inhibitors inhibitors|amod|END_ENTITY	Impact of ramipril versus other angiotensin-converting_enzyme inhibitors on outcome of unselected patients with ST-elevation acute myocardial_infarction .
14731077	0	ramipril	36,44	angiotensin-converting_enzyme	59,88	ramipril	angiotensin-converting enzyme	MESH:D017257	24310(Tax:10116)	Chemical	Gene	radiation_injury|nmod|START_ENTITY Modification|nmod|radiation_injury Modification|appos|inhibitor inhibitor|nmod|END_ENTITY	Modification of radiation_injury by ramipril , inhibitor of angiotensin-converting_enzyme , on optic_neuropathy in the rat .
15222408	0	ramipril	68,76	angiotensin-converting_enzyme	27,56	ramipril	angiotensin-converting enzyme	MESH:D017257	1636	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Hemodynamic effects of the angiotensin-converting_enzyme inhibitor , ramipril , in patients with mild to moderate aortic_stenosis and preserved left ventricular function .
1725027	0	ramipril	76,84	angiotensin-converting_enzyme	36,65	ramipril	angiotensin-converting enzyme	MESH:D017257	1636	Chemical	Gene	START_ENTITY|nsubj|Comparison Comparison|nmod|rates rates|nmod|inhibitor inhibitor|amod|END_ENTITY	Comparison of response rates to the angiotensin-converting_enzyme inhibitor ramipril in mild-to-moderate hypertension in a double-blind , parallel-group study and an open single-blind study .
19875309	0	ramipril	91,99	angiotensin-converting_enzyme	51,80	ramipril	angiotensin-converting enzyme	MESH:D017257	1636	Chemical	Gene	START_ENTITY|nsubj|vasopressin vasopressin|nmod|patients patients|acl|receiving receiving|dobj|inhibitor inhibitor|amod|END_ENTITY	Prophylactic vasopressin in patients receiving the angiotensin-converting_enzyme inhibitor ramipril undergoing coronary artery bypass graft surgery .
23933903	0	ramipril	69,77	angiotensin-converting_enzyme	8,37	ramipril	angiotensin-converting enzyme	MESH:D017257	1636	Chemical	Gene	focus|nmod|START_ENTITY equal|ccomp|focus equal|nsubj|inhibitors inhibitors|amod|END_ENTITY	Not all angiotensin-converting_enzyme inhibitors are equal : focus on ramipril and perindopril .
3016405	0	ramipril	60,68	angiotensin-converting_enzyme	19,48	ramipril	angiotensin-converting enzyme	MESH:D017257	1636	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Effects of the new angiotensin-converting_enzyme inhibitor , ramipril , in patients with essential hypertension .
15958311	0	ramipril	170,178	angiotensin_converting_enzyme	21,50	ramipril	angiotensin converting enzyme	MESH:D017257	1636	Chemical	Gene	-RSB-|amod|START_ENTITY treated|nmod|-RSB- atherosclerosis|acl|treated I/D|nmod|atherosclerosis I/D|nsubj|Association Association|nmod|END_ENTITY	-LSB- Association between angiotensin_converting_enzyme I/D polymorphism and high-sensitivity C-reactive protein in type 2 diabetic patients with atherosclerosis treated with ramipril -RSB- .
16598590	0	ramipril	154,162	angiotensin_converting_enzyme	37,66	ramipril	angiotensin converting enzyme	MESH:D017257	1636	Chemical	Gene	patients|nmod|START_ENTITY platelet_aggregation|nmod|patients comparison|nmod|platelet_aggregation effects|dep|comparison effects|nmod|inhibitors inhibitors|amod|END_ENTITY	Differential antiplatelet effects of angiotensin_converting_enzyme inhibitors : comparison of ex vivo platelet_aggregation in cardiovascular patients with ramipril , captopril and enalapril .
1661764	0	ramipril	47,55	angiotensin_converting_enzyme	14,43	ramipril	angiotensin converting enzyme	MESH:D017257	1636	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of angiotensin_converting_enzyme by ramipril in serum and tissue of man .
2138704	0	ramipril	62,70	angiotensin_converting_enzyme	22,51	ramipril	angiotensin converting enzyme	MESH:D017257	1636	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|inhibitor inhibitor|amod|END_ENTITY	-LSB- Acute effects of the angiotensin_converting_enzyme inhibitor ramipril in patients with coronary_heart_disease -RSB- .
2173610	0	ramipril	68,76	angiotensin_converting_enzyme	28,57	ramipril	angiotensin converting enzyme	MESH:D017257	24310(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|conversion conversion|nmod|inhibitor inhibitor|compound|END_ENTITY	Rapid conversion of the new angiotensin_converting_enzyme inhibitor ramipril to its active metabolite in rats .
2969671	0	ramipril	121,129	angiotensin_converting_enzyme	80,109	ramipril	angiotensin converting enzyme	MESH:D017257	1636	Chemical	Gene	START_ENTITY|nsubj|response response|nmod|inhibitor inhibitor|compound|END_ENTITY	First dose response and 24-hour antihypertensive efficacy of the new once-daily angiotensin_converting_enzyme inhibitor , ramipril .
3028436	0	ramipril	61,69	angiotensin_converting_enzyme	21,50	ramipril	angiotensin converting enzyme	MESH:D017257	24310(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Influence Influence|nmod|inhibitor inhibitor|compound|END_ENTITY	Influence of the new angiotensin_converting_enzyme inhibitor ramipril on several models of acute inflammation and the adjuvant_arthritis in the rat .
3028438	0	ramipril	82,90	angiotensin_converting_enzyme	42,71	ramipril	angiotensin converting enzyme	MESH:D017257	1636	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Humoral and blood pressure effects of the angiotensin_converting_enzyme inhibitor ramipril in essential hypertension .
3034016	0	ramipril	96,104	angiotensin_converting_enzyme	55,84	ramipril	angiotensin converting enzyme	MESH:D017257	1636	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Efficacy , tolerance and hormonal effects of a new oral angiotensin_converting_enzyme inhibitor , ramipril -LRB- HOE_498 -RRB- , in mild to moderate primary hypertension .
3034017	0	ramipril	127,135	angiotensin_converting_enzyme	87,116	ramipril	angiotensin converting enzyme	MESH:D017257	1636	Chemical	Gene	START_ENTITY|nsubj|study study|acl|compare compare|dobj|efficacy efficacy|nmod|doses doses|nmod|inhibitor inhibitor|amod|END_ENTITY	A double-blind study to compare the efficacy , tolerance and safety of two doses of the angiotensin_converting_enzyme inhibitor ramipril with placebo .
3034021	0	ramipril	70,78	angiotensin_converting_enzyme	30,59	ramipril	angiotensin converting enzyme	MESH:D017257	1636	Chemical	Gene	START_ENTITY|nsubj|relation relation|nmod|inhibitor inhibitor|amod|END_ENTITY	Dose-response relation of the angiotensin_converting_enzyme inhibitor ramipril in mild to moderate essential hypertension .
12010742	5	ramipril	1225,1233	rats	1237,1241	ramipril	nNOS	MESH:D017257	24598(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nmod|END_ENTITY	Thus mineralocorticoid substitution prevented the fall of systolic blood pressure and of glomerular filtration induced by ramipril in rats on low-salt diet .
21900941	0	ramipril	74,82	renin	43,48	ramipril	renin	MESH:D017257	5972	Chemical	Gene	Efficacy|nmod|START_ENTITY Efficacy|appos|inhibitor inhibitor|compound|END_ENTITY	Efficacy and safety of aliskiren , a direct renin inhibitor , compared with ramipril in Asian patients with mild to moderate hypertension .
3023553	0	ramipril	114,122	renin	48,53	ramipril	renin	MESH:D017257	5972	Chemical	Gene	doses|nmod|START_ENTITY END_ENTITY|nmod|doses	Twenty-four hour changes in active and inactive renin after various oral doses of the converting enzyme inhibitor ramipril -LRB- HOE498 -RRB- in normal man .
18296863	0	ramosetron	22,32	5-HT3-receptor	57,71	ramosetron	5-HT3-receptor	MESH:C071315	79246(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|antagonist antagonist|amod|END_ENTITY	Inhibitory effects of ramosetron , a potent and selective 5-HT3-receptor antagonist , on conditioned_fear_stress-induced abnormal defecation and normal defecation in rats : comparative studies with antidiarrheal and spasmolytic agents .
6166964	0	ranatensin	85,95	pancreatic_polypeptide	22,44	ranatensin	pancreatic polypeptide	MESH:C003291	5539	Chemical	Gene	Stimulation|nmod|START_ENTITY Stimulation|nmod|END_ENTITY	Stimulation of canine pancreatic_polypeptide , gastrin , and gastric_acid secretion by ranatensin , litorin , bombesin_nonapeptide and substance_P .
6135642	0	ranitidine	11,21	gastric_intrinsic_factor	38,62	ranitidine	gastric intrinsic factor	MESH:D011899	2694	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|nmod|END_ENTITY	-LSB- Effect of ranitidine on secretion of gastric_intrinsic_factor and absorption of vitamin_B_12 -RSB- .
12503773	0	ranitidine	66,76	gastrin	87,94	ranitidine	gastrin	MESH:D011899	2520	Chemical	Gene	Effects|appos|START_ENTITY Effects|nmod|level level|compound|END_ENTITY	Effects of three H2-receptor antagonists -LRB- cimetidine , famotidine , ranitidine -RRB- on serum gastrin level .
2401392	0	ranitidine	20,30	gastrin	51,58	ranitidine	gastrin	MESH:D011899	25320(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY Effect|nmod|treatment Effect|nmod|levels levels|compound|END_ENTITY	Effect of 20 weeks ' ranitidine treatment on plasma gastrin levels and gastric enterochromaffin-like cell density in the rat .
2410935	0	ranitidine	42,52	gastrin	80,87	ranitidine	gastrin	MESH:D011899	2520	Chemical	Gene	treatment|nmod|START_ENTITY Effects|nmod|treatment Effects|nmod|END_ENTITY	Effects of eight-week treatment with oral ranitidine on plasma level changes of gastrin , histamine and serotonin in duodenal ulcer patients .
2565384	0	ranitidine	17,27	gastrin	65,72	ranitidine	gastrin	MESH:D011899	25320(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Acute effects of ranitidine , famotidine and omeprazole on plasma gastrin in the rat .
2979226	0	ranitidine	111,121	gastrin	49,56	ranitidine	gastrin	MESH:D011899	2520	Chemical	Gene	intragastric|nmod|START_ENTITY intragastric|dobj|concentration concentration|compound|END_ENTITY	Twenty-four-hour intragastric acidity and plasma gastrin concentration before and during treatment with either ranitidine or omeprazole .
1353559	0	ranitidine	28,38	interleukin-2	82,95	ranitidine	interleukin-2	MESH:D011899	3558	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	Effect of indomethacin plus ranitidine in advanced melanoma patients on high-dose interleukin-2 .
2575550	0	ranitidine	48,58	somatostatin	30,42	ranitidine	somatostatin	MESH:D011899	6750	Chemical	Gene	trial|nmod|START_ENTITY trial|nmod|END_ENTITY	Clinical , controlled trial of somatostatin with ranitidine and placebo in the control of peptic hemorrhage of the upper gastrointestinal tract .
8472980	0	ranitidine_bismuth_citrate	10,36	gastrin	60,67	ranitidine bismuth citrate	gastrin	MESH:C073340	2520	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of ranitidine_bismuth_citrate on postprandial plasma gastrin and pepsinogens .
6117373	0	ranitidine_hydrochloride	14,38	intrinsic_factor	83,99	ranitidine hydrochloride	intrinsic factor	MESH:D011899	2694	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|compound|END_ENTITY	The effect of ranitidine_hydrochloride , a new histamine H2-receptor antagonist , on intrinsic_factor secretion .
20298924	0	ranolazine	45,55	B-type_natriuretic_peptide	0,26	ranolazine	B-type natriuretic peptide	MESH:C055512	4879	Chemical	Gene	effect|nmod|START_ENTITY effect|amod|END_ENTITY	B-type_natriuretic_peptide and the effect of ranolazine in patients with non-ST-segment elevation acute_coronary_syndromes : observations from the MERLIN-TIMI 36 -LRB- Metabolic Efficiency With Ranolazine for Less Ischemia in Non-ST Elevation Acute Coronary-Thrombolysis In Myocardial_Infarction 36 -RRB- trial .
19120326	0	rapamycin	105,114	AKT	40,43	rapamycin	AKT	MESH:D020123	207	Chemical	Gene	treatment|nmod|START_ENTITY cells|nmod|treatment phosphorylation|nmod|cells phosphorylation|compound|END_ENTITY	Suppression of mTOR complex 2-dependent AKT phosphorylation in melanoma cells by combined treatment with rapamycin and LY294002 .
16952420	0	rapamycin	11,20	Akt/PKB	146,153	rapamycin	Akt/PKB	MESH:D020123	207	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of rapamycin on cell proliferation and phosphorylation of mTOR and p70 -LRB- S6K -RRB- in HepG2 and HepG2 cells overexpressing constitutively active Akt/PKB .
18261725	0	rapamycin	21,30	Akt/PKB	80,87	rapamycin	Akt/PKB	MESH:D020123	207	Chemical	Gene	treatment|compound|START_ENTITY effects|nmod|treatment mediated|nsubj|effects mediated|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Long-term effects of rapamycin treatment on insulin mediated phosphorylation of Akt/PKB and glycogen_synthase activity .
21823021	0	rapamycin	11,20	Bcl-2	38,43	rapamycin	Bcl-2	MESH:D020123	596	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effects of rapamycin on expression of Bcl-2 and Bax in human lens epithelial cells and cell cycle in rats .
23726640	0	rapamycin	36,45	Calcineurin_inhibitor	0,21	rapamycin	Calcineurin inhibitor	MESH:D020123	23523	Chemical	Gene	conversion|nmod|START_ENTITY conversion|amod|END_ENTITY	Calcineurin_inhibitor conversion to rapamycin can improve graft function in living donor kidney transplantation with older donors .
20466002	0	rapamycin	20,29	Cdk4	114,118	rapamycin	Cdk4	MESH:D020123	1019	Chemical	Gene	signaling|amod|START_ENTITY target|nmod|signaling opposes|nsubj|target opposes|advcl|leading leading|nmod|activation activation|nmod|END_ENTITY	Mammalian target of rapamycin complex 1 signaling opposes the effects of anchorage loss , leading to activation of Cdk4 and Cdc6 stabilization .
19524730	0	rapamycin	55,64	Cyclooxygenase_2	0,16	rapamycin	Cyclooxygenase 2	MESH:D020123	5743	Chemical	Gene	effect|nmod|START_ENTITY mediates|dobj|effect mediates|nsubj|END_ENTITY	Cyclooxygenase_2 mediates the antiangiogenic effect of rapamycin in Ewing_sarcoma .
24389203	0	rapamycin	11,20	DC-SIGN	24,31	rapamycin	DC-SIGN	MESH:D020123	30835	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|amod|END_ENTITY	Effects of rapamycin on DC-SIGN expression and biological functions in DC .
22556409	0	rapamycin	153,162	ERK	106,109	rapamycin	ERK	MESH:D020123	5594	Chemical	Gene	complex|compound|START_ENTITY target|nmod|complex cells|nmod|target extracellular_signal-regulated_kinase|nmod|cells extracellular_signal-regulated_kinase|appos|END_ENTITY	The PP242 mammalian target of rapamycin -LRB- mTOR -RRB- inhibitor activates extracellular_signal-regulated_kinase -LRB- ERK -RRB- in multiple_myeloma cells via a target of rapamycin complex 1 -LRB- TORC1 -RRB- / eukaryotic_translation_initiation_factor_4E -LRB- eIF-4E -RRB- / RAF pathway and activation is a mechanism of resistance .
22556409	0	rapamycin	30,39	ERK	106,109	rapamycin	ERK	MESH:D020123	5594	Chemical	Gene	target|nmod|START_ENTITY inhibitor|nsubj|target activates|dep|inhibitor activates|nsubj|extracellular_signal-regulated_kinase extracellular_signal-regulated_kinase|appos|END_ENTITY	The PP242 mammalian target of rapamycin -LRB- mTOR -RRB- inhibitor activates extracellular_signal-regulated_kinase -LRB- ERK -RRB- in multiple_myeloma cells via a target of rapamycin complex 1 -LRB- TORC1 -RRB- / eukaryotic_translation_initiation_factor_4E -LRB- eIF-4E -RRB- / RAF pathway and activation is a mechanism of resistance .
1375932	0	rapamycin	44,53	FKBP25	71,77	rapamycin	FKBP25	MESH:D020123	2287	Chemical	Gene	START_ENTITY|dobj|protein protein|appos|END_ENTITY	Molecular cloning of a 25-kDa high affinity rapamycin binding protein , FKBP25 .
24879919	0	rapamycin	51,60	FKBP25	23,29	rapamycin	FKBP25	MESH:D020123	2287	Chemical	Gene	targets|nmod|START_ENTITY targets|nmod|END_ENTITY	Diversified targets of FKBP25 and its complex with rapamycin .
18812505	0	rapamycin	62,71	Fpr1	57,61	rapamycin	Fpr1	MESH:D020123	855587(Tax:4932)	Chemical	Gene	complex|amod|START_ENTITY END_ENTITY|amod|complex	Superoxide anions regulate TORC1 and its ability to bind Fpr1 : rapamycin complex .
20010125	0	rapamycin	69,78	GLUT4	25,30	rapamycin	GLUT4	MESH:D020123	6517	Chemical	Gene	target|nmod|START_ENTITY END_ENTITY|nmod|target	Cycle training increased GLUT4 and activation of mammalian target of rapamycin in fast twitch muscle fibers .
19414743	0	rapamycin	68,77	GRAIL	92,97	rapamycin	GRAIL	MESH:D020123	79589	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Naive CD4 t cell proliferation is controlled by mammalian target of rapamycin regulation of GRAIL expression .
23838998	0	rapamycin	31,40	Galectin-9	0,10	rapamycin	Galectin-9	MESH:D020123	16859(Tax:10090)	Chemical	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	Galectin-9 in combination with rapamycin induces cardiac allograft tolerance in mice .
17347776	0	rapamycin	218,227	HER-2	59,64	rapamycin	HER-2	MESH:D020123	2064	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	Decreased levels of hypoxic cells in gefitinib treated ER + HER-2 overexpressing MCF-7 breast_cancer_tumors are associated with hyperactivation of the mTOR pathway : therapeutic implications for combination therapy with rapamycin .
16357868	0	rapamycin	52,61	Heme_oxygenase-1	0,16	rapamycin	Heme oxygenase-1	MESH:D020123	24451(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY mediates|dobj|effects mediates|nsubj|END_ENTITY	Heme_oxygenase-1 mediates the protective effects of rapamycin in monocrotaline-induced pulmonary_hypertension .
24970820	0	rapamycin	93,102	Hsp90	171,176	rapamycin	Hsp90	MESH:D020123	855836(Tax:4932)	Chemical	Gene	factor|nmod|START_ENTITY inhibition|nmod|factor yeast|nmod|inhibition Insights|nmod|yeast prevent|nsubj|Insights prevent|dobj|activation activation|acl:relcl|results results|nmod|inhibitor inhibitor|amod|END_ENTITY	Insights from yeast into whether the inhibition of heat_shock transcription factor -LRB- Hsf1 -RRB- by rapamycin can prevent the Hsf1 activation that results from treatment with an Hsp90 inhibitor .
18630505	0	rapamycin	40,49	IGF-I_receptor	0,14	rapamycin	IGF-I receptor	MESH:D020123	3480	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	IGF-I_receptor inhibition combined with rapamycin or temsirolimus inhibits neuroblastoma cell growth .
19528451	0	rapamycin	59,68	IGF-I_receptor	14,28	rapamycin	IGF-I receptor	MESH:D020123	3480	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Inhibition of IGF-I_receptor signaling in combination with rapamycin or temsirolimus increases MYC-N phosphorylation .
8565319	0	rapamycin	10,19	IL-2_receptor	45,58	rapamycin	IL-2 receptor	MESH:D020123	3560	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	Effect of rapamycin on the expression of the IL-2_receptor -LRB- CD25 -RRB- .
23913957	0	rapamycin	22,31	IL-4	52,56	rapamycin	IL-4	MESH:D020123	3565	Chemical	Gene	activation|compound|START_ENTITY target|nmod|activation triggers|nsubj|target triggers|dobj|production production|compound|END_ENTITY	Mechanistic target of rapamycin activation triggers IL-4 production and necrotic death of double-negative T cells in patients with systemic_lupus_erythematosus .
7689258	0	rapamycin	14,23	IL-4	52,56	rapamycin	IL-4	MESH:D020123	3565	Chemical	Gene	Evidence|dep|START_ENTITY has|nsubj|Evidence has|dobj|effects effects|nmod|function function|compound|END_ENTITY	Evidence that rapamycin has differential effects of IL-4 function .
19729590	0	rapamycin	56,65	Insulin	0,7	rapamycin	Insulin	MESH:D020123	3630	Chemical	Gene	activity|amod|START_ENTITY target|nmod|activity resistance|nmod|target resistance|compound|END_ENTITY	Insulin resistance without elevated mammalian target of rapamycin complex 1 activity in muscles of mice fed a high-fat diet .
12559758	0	rapamycin	26,35	Insulin/IGF	0,11	rapamycin	Insulin/IGF	MESH:D020123	42549(Tax:7227)	Chemical	Gene	signaling|compound|START_ENTITY END_ENTITY|nmod|signaling	Insulin/IGF and target of rapamycin signaling : a TOR de force in growth control .
18519772	0	rapamycin	94,103	Mammalian_target_of_rapamycin	43,72	rapamycin	mammalian target of rapamycin	MESH:D020123	2475	Chemical	Gene	kinase|nmod|START_ENTITY kinase|nsubj|Changes Changes|nmod|metabolism metabolism|nmod|readout readout|nmod|END_ENTITY	Changes in tumor metabolism as readout for Mammalian_target_of_rapamycin kinase inhibition by rapamycin in glioblastoma .
19509067	0	rapamycin	41,50	Mammalian_target_of_rapamycin	0,29	rapamycin	Mammalian target of rapamycin	MESH:D020123	2475	Chemical	Gene	induce|nsubj|START_ENTITY inhibitors|ccomp|induce inhibitors|nsubj|END_ENTITY	Mammalian_target_of_rapamycin inhibitors rapamycin and RAD001 -LRB- everolimus -RRB- induce anti-proliferative effects in GH-secreting pituitary_tumor cells in vitro .
19963098	0	rapamycin	44,53	Mammalian_target_of_rapamycin	0,29	rapamycin	Mammalian target of rapamycin	MESH:D020123	2475	Chemical	Gene	discovery|nmod|START_ENTITY reveals|nsubj|discovery END_ENTITY|parataxis|reveals	Mammalian_target_of_rapamycin : discovery of rapamycin reveals a signaling pathway important for normal and cancer cell growth .
24371138	0	rapamycin	53,62	Mammalian_target_of_rapamycin	0,29	rapamycin	Mammalian target of rapamycin	MESH:D020123	56717(Tax:10090)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibition with rapamycin improves cardiac function in type 2 diabetic mice : potential role of attenuated oxidative stress and altered contractile protein expression .
23555865	0	rapamycin	26,35	MicroRNA-21	0,11	rapamycin	MicroRNA-21	MESH:D020123	406991	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	MicroRNA-21 is induced by rapamycin in a model of tuberous_sclerosis -LRB- TSC -RRB- and lymphangioleiomyomatosis -LRB- LAM -RRB- .
19664332	0	rapamycin	12,21	PC-3	41,45	rapamycin	PC-3	MESH:D020123	3853	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	-LSB- Effects of rapamycin on prostate_cancer PC-3 cells -RSB- .
26011939	0	rapamycin	32,41	PrLZ	5,9	rapamycin	PrLZ	MESH:D020123	7163	Chemical	Gene	confers|advcl|START_ENTITY confers|nsubj|END_ENTITY	PC-1 / PrLZ confers resistance to rapamycin in prostate_cancer cells through increased 4E-BP1 stability .
16322523	0	rapamycin	111,120	RRD1	51,55	rapamycin	RRD1	MESH:D020123	854653(Tax:4932)	Chemical	Gene	exposure|compound|START_ENTITY modulate|nmod|exposure required|xcomp|modulate required|nsubjpass|END_ENTITY	The Saccharomyces_cerevisiae phosphatase activator RRD1 is required to modulate gene expression in response to rapamycin exposure .
19059405	0	rapamycin	54,63	Redd1	81,86	rapamycin	Redd1	MESH:D020123	54541	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	SP600125 negatively regulates the mammalian target of rapamycin via ATF4-induced Redd1 expression .
23426372	0	rapamycin	69,78	Rheb	0,4	rapamycin	Rheb	MESH:D020123	6009	Chemical	Gene	target|nmod|START_ENTITY END_ENTITY|dep|target	Rheb -LRB- Ras_homologue_enriched_in_brain -RRB- - dependent mammalian target of rapamycin complex 1 -LRB- mTORC1 -RRB- activation becomes indispensable for cardiac hypertrophic_growth after early postnatal period .
15627783	0	rapamycin	74,83	RhoA	29,33	rapamycin	RhoA	MESH:D020123	387	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|dep|effect	Stent implantation activates RhoA in human arteries : inhibitory effect of rapamycin .
24316235	0	rapamycin	59,68	RhoA	0,4	rapamycin	RhoA	MESH:D020123	387	Chemical	Gene	target|nmod|START_ENTITY signaling|nmod|target modulates|xcomp|signaling modulates|nsubj|END_ENTITY	RhoA modulates signaling through the mechanistic target of rapamycin complex 1 -LRB- mTORC1 -RRB- in mammalian cells .
21129186	0	rapamycin	49,58	Rrd1	0,4	rapamycin	Rrd1	MESH:D020123	854653(Tax:4932)	Chemical	Gene	isomerizes|nmod|START_ENTITY isomerizes|nsubj|END_ENTITY	Rrd1 isomerizes RNA polymerase II in response to rapamycin .
21639830	0	rapamycin	75,84	Rrd1	14,18	rapamycin	Rrd1	MESH:D020123	854653(Tax:4932)	Chemical	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	The isomerase Rrd1 mediates rapid loss of the Sgs1 helicase in response to rapamycin .
23839034	0	rapamycin	8,17	S6K1	39,43	rapamycin	S6K1	MESH:D020123	72508(Tax:10090)	Chemical	Gene	treatment|compound|START_ENTITY treatment|nmod|END_ENTITY	Chronic rapamycin treatment or lack of S6K1 does not reduce ribosome activity in vivo .
24239466	3	rapamycin	764,773	S6K1	795,799	rapamycin	S6K1	MESH:D020123	6198	Chemical	Gene	concentration|nmod|START_ENTITY RESULTS|dep|concentration blocked|nsubj|RESULTS blocked|dobj|END_ENTITY	RESULTS : A high concentration of rapamycin -LRB- 10 M -RRB- blocked both S6K1 and elF4E phosphorylation and inhibited cell proliferation in T24 and 5637 cells .
24760501	7	rapamycin	1054,1063	S6K1	1140,1144	rapamycin	S6K1	MESH:D020123	6198	Chemical	Gene	dose|compound|START_ENTITY reduced|nsubj|dose reduced|dobj|insulin insulin|dep|END_ENTITY	A low rapamycin dose -LRB- 2.5 nmol/L -RRB- significantly reduced the insulin - -LRB- 0.5 nmol/L -RRB- stimulated S6K1 and S6 phosphorylation .
27083004	1	rapamycin	143,152	S6K1	263,267	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	target|nmod|START_ENTITY UNASSIGNED|dep|target plays|nsubj|UNASSIGNED plays|parataxis|extended extended|nsubj|mice mice|acl|lacking lacking|dobj|S6 S6|appos|END_ENTITY	UNASSIGNED : The mechanistic target of rapamycin -LRB- mTOR -RRB- signalling pathway plays a highly conserved role in aging ; mice lacking ribosomal protein S6 kinase 1 -LRB- S6K1 - / - -RRB- have extended lifespan and healthspan relative to wild_type -LRB- WT -RRB- controls .
16859513	0	rapamycin	19,28	Skp2	91,95	rapamycin	Skp2	MESH:D020123	6502	Chemical	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|nmod|END_ENTITY	The mTOR inhibitor rapamycin down-regulates the expression of the ubiquitin ligase subunit Skp2 in breast_cancer cells .
19099956	0	rapamycin	27,36	Smad_3	40,46	rapamycin	Smad 3	MESH:D020123	25631(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|protein protein|amod|END_ENTITY	-LSB- Effects of mTOR inhibitor rapamycin on Smad_3 protein and collagen type I expression in rat myocardial fibroblasts infected with coxsackie virus B 3 -RSB- .
26837772	0	rapamycin	14,23	TGFb1	27,32	rapamycin	TGFb1	MESH:D020123	100008645(Tax:9986)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of rapamycin on TGFb1 and MMP1 expression in a rabbit model of urethral_stricture .
20854798	0	rapamycin	112,121	TIMP-1	54,60	rapamycin	TIMP-1	MESH:D020123	116510(Tax:10116)	Chemical	Gene	system|nmod|START_ENTITY system|compound|END_ENTITY	Differential modulation of the cytokine-induced MMP-9 / TIMP-1 protease-antiprotease system by the mTOR inhibitor rapamycin .
11983923	0	rapamycin	60,69	TOR	45,48	rapamycin	TOR	MESH:D020123	841427(Tax:3702)	Chemical	Gene	target|nmod|START_ENTITY END_ENTITY|dep|target	Expression and disruption of the Arabidopsis TOR -LRB- target of rapamycin -RRB- gene .
21210909	0	rapamycin	39,48	TOR	24,27	rapamycin	TOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	target|nmod|START_ENTITY END_ENTITY|dep|target	Activating mutations of TOR -LRB- target of rapamycin -RRB- .
8387896	0	rapamycin	10,19	TOR2	30,34	rapamycin	TOR2	MESH:D020123	853632(Tax:4932)	Chemical	Gene	Target|nmod|START_ENTITY Target|appos|END_ENTITY	Target of rapamycin in yeast , TOR2 , is an essential phosphatidylinositol kinase homolog required for G1 progression .
22556409	0	rapamycin	153,162	TORC1	174,179	rapamycin	TORC1	MESH:D020123	23373	Chemical	Gene	complex|compound|START_ENTITY target|nmod|complex cells|nmod|target extracellular_signal-regulated_kinase|nmod|cells extracellular_signal-regulated_kinase|appos|END_ENTITY	The PP242 mammalian target of rapamycin -LRB- mTOR -RRB- inhibitor activates extracellular_signal-regulated_kinase -LRB- ERK -RRB- in multiple_myeloma cells via a target of rapamycin complex 1 -LRB- TORC1 -RRB- / eukaryotic_translation_initiation_factor_4E -LRB- eIF-4E -RRB- / RAF pathway and activation is a mechanism of resistance .
22556409	0	rapamycin	30,39	TORC1	174,179	rapamycin	TORC1	MESH:D020123	23373	Chemical	Gene	target|nmod|START_ENTITY inhibitor|nsubj|target activates|dep|inhibitor activates|nsubj|extracellular_signal-regulated_kinase extracellular_signal-regulated_kinase|appos|END_ENTITY	The PP242 mammalian target of rapamycin -LRB- mTOR -RRB- inhibitor activates extracellular_signal-regulated_kinase -LRB- ERK -RRB- in multiple_myeloma cells via a target of rapamycin complex 1 -LRB- TORC1 -RRB- / eukaryotic_translation_initiation_factor_4E -LRB- eIF-4E -RRB- / RAF pathway and activation is a mechanism of resistance .
14679193	0	rapamycin	121,130	Tor1/2	145,151	rapamycin	Tor1/2	MESH:D020123	853529;853632	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	Gln3 phosphorylation and intracellular localization in nutrient limitation and starvation differ from those generated by rapamycin inhibition of Tor1/2 in Saccharomyces_cerevisiae .
23223232	0	rapamycin	96,105	TorC1	120,125	rapamycin	TorC1	MESH:D020123	23373	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	gln3 mutations dissociate responses to nitrogen limitation -LRB- nitrogen catabolite repression -RRB- and rapamycin inhibition of TorC1 .
16702957	0	rapamycin	76,85	Tristetraprolin	0,15	rapamycin	Tristetraprolin	MESH:D020123	7538	Chemical	Gene	regulates|advcl|START_ENTITY regulates|nsubj|END_ENTITY	Tristetraprolin regulates Cyclin_D1 and c-Myc mRNA stability in response to rapamycin in an Akt-dependent manner via p38 MAPK signaling .
19789339	0	rapamycin	124,133	VEGF	99,103	rapamycin	VEGF	MESH:D020123	7422	Chemical	Gene	suppresses|nmod|START_ENTITY suppresses|dobj|END_ENTITY	The insulin-like_growth_factor-1_receptor-targeting antibody , CP-751 ,871 , suppresses tumor-derived VEGF and synergizes with rapamycin in models of childhood_sarcoma .
23464458	0	rapamycin	60,69	VEGF	135,139	rapamycin	VEGF	MESH:D020123	7422	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|appos|END_ENTITY	Prevalence and clinical significance of mammalian target of rapamycin phosphorylation -LRB- p-mTOR -RRB- and vascular_endothelial_growth_factor -LRB- VEGF -RRB- in clear cell carcinoma_of_the_ovary .
26427711	0	rapamycin	21,30	VEGF	62,66	rapamycin	VEGF	MESH:D020123	7422	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|downregulation downregulation|nmod|expression expression|compound|END_ENTITY	Anticancer effect of rapamycin on MCF-7 via downregulation of VEGF expression .
8242902	0	rapamycin	14,23	c-jun	27,32	rapamycin	c-jun	MESH:D020123	3725	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|amod|END_ENTITY	The effect of rapamycin on c-jun expression in human lymphocytes .
15131122	0	rapamycin	44,53	cyclin_D3	13,22	rapamycin	cyclin D3	MESH:D020123	896	Chemical	Gene	Evidence|nmod|START_ENTITY Evidence|nmod|END_ENTITY	Evidence for cyclin_D3 as a novel target of rapamycin in human T lymphocytes .
19766909	0	rapamycin	60,69	galectin-1	48,58	rapamycin	galectin-1	MESH:D020123	3956	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Use of a cocktail regimen consisting of soluble galectin-1 , rapamycin and histone deacetylase inhibitor may effectively prevent type 1 diabetes .
21295008	0	rapamycin	14,23	granulocyte-colony_stimulating_factor	57,94	rapamycin	granulocyte-colony stimulating factor	MESH:D020123	12985(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Inhibition by rapamycin of the lipoteichoic_acid-induced granulocyte-colony_stimulating_factor expression in mouse macrophages .
12591764	0	rapamycin	120,129	heme_oxygenase-1	18,34	rapamycin	heme oxygenase-1	MESH:D020123	3162	Chemical	Gene	induces|nmod|START_ENTITY induces|xcomp|END_ENTITY	Rapamycin induces heme_oxygenase-1 in human pulmonary vascular cells : implications in the antiproliferative response to rapamycin .
26449763	0	rapamycin	22,31	insulin	63,70	rapamycin	insulin	MESH:D020123	3630	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|resistance resistance|compound|END_ENTITY	Paradoxical effect of rapamycin on inflammatory stress-induced insulin resistance in vitro and in vivo .
14508096	0	rapamycin	24,33	mTOR	35,39	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	target|nmod|START_ENTITY target|appos|END_ENTITY	The molecular target of rapamycin -LRB- mTOR -RRB- as a therapeutic target against cancer .
15184287	0	rapamycin	34,43	mTOR	14,18	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	regresses|compound|START_ENTITY signaling|nmod|regresses END_ENTITY|acl|signaling	Inhibition of mTOR signaling with rapamycin regresses established cardiac_hypertrophy induced by pressure overload .
15784722	0	rapamycin	147,156	mTOR	18,22	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	dissection|nmod|START_ENTITY Identification|dep|dissection Identification|nmod|END_ENTITY	Identification of mTOR as a novel bifunctional target in chronic_myeloid_leukemia : dissection of growth-inhibitory and VEGF-suppressive effects of rapamycin in leukemic cells .
16193082	0	rapamycin	40,49	mTOR	32,36	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	targeting|nmod|START_ENTITY targeting|dobj|END_ENTITY	Synergistic effect of targeting mTOR by rapamycin and depleting ATP by inhibition of glycolysis in lymphoma and leukemia cells .
16217558	0	rapamycin	28,37	mTOR	39,43	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	The mammalian target of the rapamycin -LRB- mTOR -RRB- kinase pathway : its role in tumourigenesis and targeted antitumour therapy .
16364254	0	rapamycin	34,43	mTOR	14,18	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Inhibition of mTOR signaling with rapamycin attenuates renal_hypertrophy in the early diabetic mice .
16540312	0	rapamycin	58,67	mTOR	49,53	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	mammalian_target_of_rapamycin|nmod|START_ENTITY mammalian_target_of_rapamycin|appos|END_ENTITY	Inhibition of the mammalian_target_of_rapamycin -LRB- mTOR -RRB- by rapamycin increases chemosensitivity of CaSki cells to paclitaxel .
17347776	0	rapamycin	218,227	mTOR	150,154	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	associated|nmod|START_ENTITY associated|nmod|hyperactivation hyperactivation|nmod|pathway pathway|compound|END_ENTITY	Decreased levels of hypoxic cells in gefitinib treated ER + HER-2 overexpressing MCF-7 breast_cancer_tumors are associated with hyperactivation of the mTOR pathway : therapeutic implications for combination therapy with rapamycin .
17360108	0	rapamycin	125,134	mTOR	153,157	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	signaling|nmod|START_ENTITY signaling|nmod|END_ENTITY	An activated mTOR/p70S6K signaling pathway in esophageal_squamous_cell_carcinoma cell lines and inhibition of the pathway by rapamycin and siRNA against mTOR .
17584050	0	rapamycin	17,26	mTOR	0,4	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	inhibitors|dep|START_ENTITY inhibitors|compound|END_ENTITY	mTOR inhibitors -LRB- rapamycin and its derivatives -RRB- and nitrogen containing bisphosphonates : bi-functional compounds for the treatment of bone_tumours .
17635004	0	rapamycin	48,57	mTOR	33,37	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|testing testing|nmod|inhibitor inhibitor|compound|END_ENTITY	Initial testing -LRB- stage 1 -RRB- of the mTOR inhibitor rapamycin by the pediatric preclinical testing program .
17804702	5	rapamycin	921,930	mTOR	948,952	rapamycin	EGFR	MESH:D020123	1956	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	To address the importance of PI3K blockade , we showed in PTEN -LRB- mt -RRB- glioma that combining PI-103 and erlotinib was superior to either monotherapy or to therapy combining erlotinib with either rapamycin -LRB- an inhibitor of mTOR -RRB- or PIK-90 -LRB- an inhibitor of PI3Kalpha -RRB- .
18075305	0	rapamycin	37,46	mTOR	22,26	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|effect effect|nmod|END_ENTITY	Synergistic effect of mTOR inhibitor rapamycin and fluorouracil in inducing apoptosis and cell senescence in hepatocarcinoma cells .
18094032	0	rapamycin	28,37	mTOR	9,13	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Low-dose mTOR inhibition by rapamycin attenuates progression in anti-thy1-induced chronic_glomerulosclerosis of the rat .
18174523	0	rapamycin	19,28	mTOR	0,4	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	mTOR inhibition by rapamycin prevents beta-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes .
18534253	0	rapamycin	31,40	mTOR	76,80	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|Implications Implications|nmod|inhibition inhibition|compound|END_ENTITY	Antidepressive-like effects of rapamycin in animal models : Implications for mTOR inhibition as a new target for treatment of affective_disorders .
18757421	0	rapamycin	87,96	mTOR	66,70	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|Chemoprevention Chemoprevention|nmod|disease disease|nmod|END_ENTITY	Chemoprevention and treatment of experimental Cowden 's _ disease by mTOR inhibition with rapamycin .
18783828	0	rapamycin	55,64	mTOR	99,103	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	lines|nmod|START_ENTITY Hypersensitivity|nmod|lines Hypersensitivity|dep|application application|nmod|inhibitor inhibitor|compound|END_ENTITY	Hypersensitivity of Ph-positive lymphoid cell lines to rapamycin : Possible clinical application of mTOR inhibitor .
19120326	0	rapamycin	105,114	mTOR	15,19	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	treatment|nmod|START_ENTITY cells|nmod|treatment phosphorylation|nmod|cells phosphorylation|compound|END_ENTITY	Suppression of mTOR complex 2-dependent AKT phosphorylation in melanoma cells by combined treatment with rapamycin and LY294002 .
19176057	0	rapamycin	39,48	mTOR	13,17	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	-LSB- Blockage of mTOR signaling pathway by rapamycin contributes to inhibition of tumor cell proliferation in ALK-positive lymphoid cell strains -RSB- .
19270529	0	rapamycin	20,29	mTOR	10,14	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	Targeting|nmod|START_ENTITY Targeting|dobj|END_ENTITY	Targeting mTOR with rapamycin : one dose does not fit all .
19853373	0	rapamycin	15,24	mTOR	0,4	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	inhibitor|dep|START_ENTITY inhibitor|compound|END_ENTITY	mTOR inhibitor rapamycin alone or combined with cisplatin inhibits growth of esophageal_squamous_cell_carcinoma in nude_mice .
19901542	0	rapamycin	51,60	mTOR	10,14	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	thinking|nmod|START_ENTITY END_ENTITY|dep|thinking	Targeting mTOR globally in cancer : thinking beyond rapamycin .
20102778	4	rapamycin	714,723	mTOR	675,679	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	doses|nmod|START_ENTITY following|nmod|doses following|dobj|inhibition inhibition|compound|END_ENTITY	The effects on HeLa cell survival and downstream signaling were determined following mTOR inhibition by increasing doses of rapamycin , or silencing by siRNA .
20177775	0	rapamycin	35,44	mTOR	64,68	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|cells cells|amod|END_ENTITY	Effect of combination treatment of rapamycin and isoflavones on mTOR pathway in human glioblastoma -LRB- U87 -RRB- cells .
20376313	0	rapamycin	22,31	mTOR	14,18	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	abolishes|compound|START_ENTITY END_ENTITY|nmod|abolishes	Inhibition of mTOR by rapamycin abolishes cognitive_deficits and reduces amyloid-beta levels in a mouse model of Alzheimer 's _ disease .
20542007	0	rapamycin	63,72	mTOR	23,27	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	inhibition|compound|START_ENTITY Structure|nmod|inhibition Structure|nmod|I I|compound|END_ENTITY	Structure of the human mTOR complex I and its implications for rapamycin inhibition .
20727967	0	rapamycin	20,29	mTOR	31,35	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	target|nmod|START_ENTITY target|appos|END_ENTITY	Mammalian target of rapamycin -LRB- mTOR -RRB- phosphorylates inositol_1 ,4,5 - trisphosphate receptor type 2 and increases its Ca -LRB- 2 + -RRB- release activity .
20811722	0	rapamycin	10,19	mTOR	24,28	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|inhibitor inhibitor|compound|END_ENTITY	Effect of rapamycin , an mTOR inhibitor , on radiation sensitivity of lung_cancer cells having different p53 gene status .
21063721	0	rapamycin	46,55	mTOR	26,30	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	enhanced|nmod|START_ENTITY enhanced|nsubjpass|accumulation accumulation|nmod|END_ENTITY	Lysosomal accumulation of mTOR is enhanced by rapamycin .
21208419	0	rapamycin	26,35	mTOR	4,8	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	decreases|compound|START_ENTITY iNOS|nsubj|decreases kinase|ccomp|iNOS kinase|nsubj|END_ENTITY	The mTOR kinase inhibitor rapamycin decreases iNOS mRNA stability in astrocytes .
21277936	7	rapamycin	1450,1459	mTOR	1510,1514	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	using|dobj|START_ENTITY studies|acl|using showed|nsubj|studies showed|dobj|effect effect|nmod|blockade blockade|compound|END_ENTITY	Functional studies using rapamycin or CCI-779 showed a dominant inhibitory effect of mTOR blockade on interleukin-7-induced proliferation , survival , and cell-cycle progression of T-ALL cells .
21993994	0	rapamycin	203,212	mTOR	177,181	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	target|nmod|START_ENTITY END_ENTITY|dep|target	AKT -LRB- v-akt murine thymoma viral oncogene homolog 1 -RRB- and N-Ras -LRB- neuroblastoma ras viral oncogene homolog -RRB- coactivation in the mouse liver promotes rapid carcinogenesis by way of mTOR -LRB- mammalian target of rapamycin complex 1 -RRB- , FOXM1 -LRB- forkhead_box_M1 -RRB- / SKP2 , and c-Myc pathways .
22014210	0	rapamycin	27,36	mTOR	8,12	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Chronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight_loss in rats .
22040565	0	rapamycin	56,65	mTOR	47,51	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	Inactivation|nmod|START_ENTITY Inactivation|appos|END_ENTITY	Inactivation of mammalian_target_of_rapamycin -LRB- mTOR -RRB- by rapamycin in a murine model of lipopolysaccharide-induced acute_lung_injury .
22071574	0	rapamycin	10,19	mTOR	76,80	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|advcl|dissociating dissociating|dobj|complex complex|compound|END_ENTITY	High-dose rapamycin induces apoptosis in human cancer cells by dissociating mTOR complex 1 and suppressing phosphorylation of 4E-BP1 .
22125057	0	rapamycin	54,63	mTOR	46,50	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Biochemical and pharmacological inhibition of mTOR by rapamycin and an ATP-competitive mTOR inhibitor .
22178316	0	rapamycin	43,52	mTOR	67,71	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	Impairment of object recognition memory by rapamycin inhibition of mTOR in the amygdala or hippocampus around the time of learning or reactivation .
22281494	0	rapamycin	32,41	mTOR	74,78	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	sensitivity|nmod|START_ENTITY associated|nsubjpass|sensitivity associated|nmod|reduction reduction|nmod|activities activities|compound|END_ENTITY	Improved insulin sensitivity by rapamycin is associated with reduction of mTOR and S6K1 activities in L6 myotubes .
22307455	0	rapamycin	62,71	mTOR	25,29	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	methylene|compound|START_ENTITY combination|nmod|methylene signaling|nmod|combination END_ENTITY|acl|signaling	Remarkable inhibition of mTOR signaling by the combination of rapamycin and 1,4-phenylenebis -LRB- methylene -RRB- selenocyanate in human prostate_cancer cells .
22333157	0	rapamycin	21,30	mTOR	0,4	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	mTOR inhibition with rapamycin causes impaired insulin signalling and glucose uptake in human subcutaneous and omental adipocytes .
22556409	0	rapamycin	153,162	mTOR	41,45	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	complex|compound|START_ENTITY target|nmod|complex cells|nmod|target extracellular_signal-regulated_kinase|nmod|cells activates|nsubj|extracellular_signal-regulated_kinase activates|dep|inhibitor inhibitor|nsubj|target target|nmod|rapamycin rapamycin|appos|END_ENTITY	The PP242 mammalian target of rapamycin -LRB- mTOR -RRB- inhibitor activates extracellular_signal-regulated_kinase -LRB- ERK -RRB- in multiple_myeloma cells via a target of rapamycin complex 1 -LRB- TORC1 -RRB- / eukaryotic_translation_initiation_factor_4E -LRB- eIF-4E -RRB- / RAF pathway and activation is a mechanism of resistance .
22958927	0	rapamycin	12,21	mTOR	23,27	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	Relief|nmod|START_ENTITY Relief|dep|inhibition inhibition|compound|END_ENTITY	Relief with rapamycin : mTOR inhibition protects against radiation-induced mucositis .
23437362	0	rapamycin	69,78	mTOR	92,96	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Different patterns of Akt and ERK feedback activation in response to rapamycin , active-site mTOR inhibitors and metformin in pancreatic_cancer cells .
23454121	0	rapamycin	22,31	mTOR	33,37	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	regulation|amod|START_ENTITY regulation|compound|END_ENTITY	Mechanistic target of rapamycin -LRB- mTOR -RRB- dependent regulation of thioredoxin_interacting_protein -LRB- TXNIP -RRB- transcription in hypoxia .
23462168	0	rapamycin	137,146	mTOR	148,152	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	C1-dependent|amod|START_ENTITY C1-dependent|appos|END_ENTITY	Increased milk protein synthesis in response to exogenous growth_hormone is associated with changes in mechanistic -LRB- mammalian -RRB- target of rapamycin -LRB- mTOR -RRB- C1-dependent and independent cell signaling .
23708663	0	rapamycin	65,74	mTOR	44,48	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Accumulation of dephosphorylated 4EBP after mTOR inhibition with rapamycin is sufficient to disrupt paracrine transformation by the KSHV vGPCR oncogene .
23783557	0	rapamycin	34,43	mTOR	45,49	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	complexes|amod|START_ENTITY complexes|appos|END_ENTITY	The role of mechanistic target of rapamycin -LRB- mTOR -RRB- complexes signaling in the immune responses .
23852509	8	rapamycin	1059,1068	mTOR	1048,1052	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	using|dobj|START_ENTITY END_ENTITY|acl|using	Inhibition of mTOR using rapamycin induces mitochondria uncoupling in control rats , suggesting a role of mTOR as a moderator of mitochondria efficiency .
23928304	0	rapamycin	44,53	mTOR	55,59	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	integrity|amod|START_ENTITY integrity|appos|END_ENTITY	Autoregulation of the mechanistic target of rapamycin -LRB- mTOR -RRB- complex 2 integrity is controlled by an ATP-dependent mechanism .
23933173	0	rapamycin	95,104	mTOR	0,4	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	nasopharyngeal_carcinoma|nmod|START_ENTITY activation|nmod|nasopharyngeal_carcinoma activation|compound|END_ENTITY	mTOR activation in immature cells of primary nasopharyngeal_carcinoma and anti-tumor effect of rapamycin in vitro and in vivo .
23949159	0	rapamycin	72,81	mTOR	56,60	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	inhibitors|dobj|START_ENTITY inhibitors|nsubj|effects effects|nmod|treatment treatment|nmod|END_ENTITY	Contrasting effects of chronic , systemic treatment with mTOR inhibitors rapamycin and metformin on adult neural progenitors in mice .
24001755	0	rapamycin	30,39	mTOR	14,18	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	kinase|nmod|START_ENTITY kinase|compound|END_ENTITY	Inhibition of mTOR kinase via rapamycin blocks persistent predator stress-induced hyperarousal .
24012802	0	rapamycin	39,48	mTOR	23,27	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	kinase|nmod|START_ENTITY kinase|compound|END_ENTITY	Systemic inhibition of mTOR kinase via rapamycin disrupts consolidation and reconsolidation of auditory fear memory .
24371138	0	rapamycin	53,62	mTOR	31,35	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|appos|END_ENTITY	Mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibition with rapamycin improves cardiac function in type 2 diabetic mice : potential role of attenuated oxidative stress and altered contractile protein expression .
24375594	0	rapamycin	70,79	mTOR	51,55	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	blocks|nmod|START_ENTITY blocks|dobj|pathway pathway|compound|END_ENTITY	The immunosuppressant tributyltin_oxide blocks the mTOR pathway , like rapamycin , albeit by a different mechanism .
24619883	0	rapamycin	80,89	mTOR	59,63	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nmod|inhibition inhibition|compound|END_ENTITY	PPARy activation attenuates glucose_intolerance induced by mTOR inhibition with rapamycin in rats .
24944633	0	rapamycin	68,77	mTOR	93,97	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	START_ENTITY|advcl|suppressing suppressing|dobj|activity activity|compound|END_ENTITY	Interferon-a enhances the susceptibility of renal_cell_carcinoma to rapamycin by suppressing mTOR activity .
25043405	0	rapamycin	91,100	mTOR	102,106	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Fructose leads to hepatic_steatosis in zebrafish that is reversed by mechanistic target of rapamycin -LRB- mTOR -RRB- inhibition .
25307040	1	rapamycin	162,171	mTOR	173,177	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	target|nmod|START_ENTITY target|appos|END_ENTITY	The mechanistic/mammalian target of rapamycin -LRB- mTOR -RRB- is inhibited clinically to suppress T cell function and prevent allograft rejection .
25349249	6	rapamycin	760,769	mTOR	774,778	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	To determine whether inhibition of mTOR signaling could attenuate LPS-induced anorexia , we performed an intracerebroventricular -LRB- i.c.v. -RRB- injection of rapamycin , an mTOR inhibitor , on LPS-treated male mice .
25389372	3	rapamycin	544,553	mTOR	516,520	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	target|nmod|START_ENTITY END_ENTITY|dep|target	Inhibitors against KRAS signaling mediators , namely , PI3K -LRB- phosphatidylinositol 3-kinase -RRB- and mTOR -LRB- mechanistic target of rapamycin -RRB- , have limited clinical efficacy as single agents in KRAS-mutant colorectal_cancer -LRB- CRC -RRB- .
26016889	0	rapamycin	26,35	mTOR	37,41	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	The mechanistic target of rapamycin -LRB- mTOR -RRB- pathway and S6_Kinase mediate diazoxide preconditioning in primary rat cortical neurons .
26315673	0	rapamycin	37,46	mTOR	8,12	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	mice|nmod|START_ENTITY inhibition|nmod|mice inhibition|compound|END_ENTITY	Chronic mTOR inhibition in mice with rapamycin alters T , B , myeloid , and innate lymphoid cells and gut flora and prolongs life of immune-deficient mice .
26323682	0	rapamycin	36,45	mTOR	8,12	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	target|nmod|START_ENTITY END_ENTITY|dep|target	Topical mTOR -LRB- mechanistic target of rapamycin -RRB- inhibitor therapy in facial angiofibroma .
26323682	0	rapamycin	36,45	mTOR	8,12	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	target|nmod|START_ENTITY END_ENTITY|dep|target	Topical mTOR -LRB- mechanistic target of rapamycin -RRB- inhibitor therapy in facial angiofibroma .
26390657	4	rapamycin	908,917	mTOR	987,991	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	rapamycin|amod|START_ENTITY target|nmod|rapamycin intervention|nmod|target observed|nmod|intervention observed|nsubj|effect effect|acl|blocking blocking|dobj|END_ENTITY	With the intervention of mammalian target of rapamycin mTOR inhibitor rapamycin -LRB- 100 nmol x L -LRB- -1 -RRB- -RRB- , the effect of blocking mTOR signaling pathway on autophagic inhibition of emodin was observed .
26390657	4	rapamycin	933,942	mTOR	987,991	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	target|nmod|START_ENTITY intervention|nmod|target observed|nmod|intervention observed|nsubj|effect effect|acl|blocking blocking|dobj|END_ENTITY	With the intervention of mammalian target of rapamycin mTOR inhibitor rapamycin -LRB- 100 nmol x L -LRB- -1 -RRB- -RRB- , the effect of blocking mTOR signaling pathway on autophagic inhibition of emodin was observed .
26477999	0	rapamycin	22,31	mTOR	33,37	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Mechanistic target of rapamycin -LRB- mTOR -RRB- expression is increased in acne patients ' skin .
26540919	0	rapamycin	112,121	mTOR	15,19	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY cells|nmod|effect stem|nsubj|cells stem|ccomp|stem stem|nsubj|Activation Activation|nmod|END_ENTITY	-LSB- Activation of mTOR signaling pathway in cancer stem cells of nasopharyngeal_carcinoma and inhibitive effect of rapamycin against the cancer stem cells -RSB- .
26588882	0	rapamycin	19,28	mTOR	0,4	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	mTOR inhibition by rapamycin protects against deltamethrin-induced apoptosis in PC12 Cells .
26698023	0	rapamycin	42,51	mTOR	14,18	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	target|nmod|START_ENTITY Activation|dep|target Activation|nmod|END_ENTITY	Activation of mTOR -LRB- mechanistic target of rapamycin -RRB- in rheumatic_diseases .
26810941	0	rapamycin	37,46	mTOR	20,24	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	inhibitors|dep|START_ENTITY inhibitors|compound|END_ENTITY	New perspectives on mTOR inhibitors -LRB- rapamycin , rapalogs and TORKinibs -RRB- in transplantation .
27045863	0	rapamycin	43,52	mTOR	86,90	rapamycin	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	extract|nmod|START_ENTITY extract|nmod|END_ENTITY	Huaier aqueous extract sensitizes cells to rapamycin and cisplatin through activating mTOR signaling .
19114562	0	rapamycin	88,97	mTORC1	14,20	rapamycin	mTORC1	MESH:D020123	382056(Tax:10090)	Chemical	Gene	competition|nmod|START_ENTITY Regulation|dep|competition Regulation|nmod|END_ENTITY	Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic_acid : competition with rapamycin .
19520853	6	rapamycin	797,806	mTORC1	818,824	rapamycin	mTORC1	MESH:D020123	382056(Tax:10090)	Chemical	Gene	complex|amod|START_ENTITY END_ENTITY|amod|complex	Basal MEK/ERK activity conferred basal Beclin_1 by preventing disassembly of mammalian target of rapamycin complex 1 -LRB- mTORC1 -RRB- and mTORC2 .
21042876	0	rapamycin	22,31	mTORC1	0,6	rapamycin	mTORC1	MESH:D020123	382056(Tax:10090)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	mTORC1 inhibition via rapamycin promotes triacylglycerol lipolysis and release of free fatty_acids in 3T3-L1 adipocytes .
21673091	0	rapamycin	110,119	mTORC1	77,83	rapamycin	mTORC1	MESH:D020123	382056(Tax:10090)	Chemical	Gene	distinct|nmod|START_ENTITY characterization|dep|distinct characterization|nmod|OSI-027 OSI-027|appos|inhibitor inhibitor|nmod|END_ENTITY	Preclinical characterization of OSI-027 , a potent and selective inhibitor of mTORC1 and mTORC2 : distinct from rapamycin .
21862237	0	rapamycin	120,129	mTORC1	0,6	rapamycin	mTORC1	MESH:D020123	382056(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY rationalizing|dobj|effects risk|parataxis|rationalizing risk|nsubj|activity activity|amod|END_ENTITY	mTORC1 activity as a determinant of cancer risk -- rationalizing the cancer-preventive effects of adiponectin , metformin , rapamycin , and low-protein vegan diets .
22143799	0	rapamycin	39,48	mTORC1	60,66	rapamycin	mTORC1	MESH:D020123	382056(Tax:10090)	Chemical	Gene	inactivation|amod|START_ENTITY inactivation|compound|END_ENTITY	Myopathy caused by mammalian target of rapamycin complex 1 -LRB- mTORC1 -RRB- inactivation is not reversed by restoring mitochondrial function .
22306200	0	rapamycin	28,37	mTORC1	9,15	rapamycin	mTORC1	MESH:D020123	382056(Tax:10090)	Chemical	Gene	Blocking|nmod|START_ENTITY Blocking|dobj|activity activity|amod|END_ENTITY	Blocking mTORC1 activity by rapamycin leads to impairment_of_spatial_memory retrieval but not acquisition in C57BL/6J mice .
22452883	0	rapamycin	131,140	mTORC1	14,20	rapamycin	mTORC1	MESH:D020123	382056(Tax:10090)	Chemical	Gene	mediating|nmod|START_ENTITY activates|advcl|mediating activates|nsubj|Inhibition Inhibition|nmod|kinase kinase|amod|END_ENTITY	Inhibition of mTORC1 kinase activates Smads_1_and_5 but not Smad8 in human prostate_cancer cells , mediating cytostatic response to rapamycin .
22474287	0	rapamycin	119,128	mTORC1	140,146	rapamycin	mTORC1	MESH:D020123	382056(Tax:10090)	Chemical	Gene	complex|compound|START_ENTITY target|nmod|complex role|nmod|target role|appos|END_ENTITY	Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 -LRB- mTORC1 -RRB- signaling .
23461035	4	rapamycin	926,935	mTORC1	876,882	rapamycin	mTORC1	MESH:D020123	382056(Tax:10090)	Chemical	Gene	inhibiting|nmod|START_ENTITY shown|advcl|inhibiting correlates|advcl|shown correlates|nmod|activation activation|nmod|END_ENTITY	Induction of senescence closely correlates with the activation of the complex mTORC1 , as it was shown by inhibiting mTORC1 with rapamycin .
23977383	0	rapamycin	58,67	mTORC1	79,85	rapamycin	mTORC1	MESH:D020123	382056(Tax:10090)	Chemical	Gene	target|nmod|START_ENTITY role|nmod|target role|appos|END_ENTITY	A new functional role for mechanistic/mammalian target of rapamycin complex 1 -LRB- mTORC1 -RRB- in the circadian regulation of L-type voltage-gated calcium channels in avian cone photoreceptors .
24303063	0	rapamycin	20,29	mTORC1	41,47	rapamycin	mTORC1	MESH:D020123	382056(Tax:10090)	Chemical	Gene	complex|compound|START_ENTITY target|nmod|complex activity|dep|target activity|amod|END_ENTITY	Mammalian target of rapamycin complex I -LRB- mTORC1 -RRB- activity in ras homologue enriched in brain -LRB- Rheb -RRB- - deficient mouse embryonic fibroblasts .
24526113	0	rapamycin	58,67	mTORC1	79,85	rapamycin	mTORC1	MESH:D020123	382056(Tax:10090)	Chemical	Gene	complex|compound|START_ENTITY target|nmod|complex signaling|nmod|target signaling|parataxis|goes goes|nsubj|END_ENTITY	Environmental signaling through the mechanistic target of rapamycin complex 1 : mTORC1 goes nuclear .
24691032	0	rapamycin	127,136	mTORC1	14,20	rapamycin	mTORC1	MESH:D020123	382056(Tax:10090)	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|Activation Activation|nmod|signaling signaling|amod|END_ENTITY	Activation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin .
25278019	4	rapamycin	743,752	mTORC1	786,792	rapamycin	mTORC1	MESH:D020123	382056(Tax:10090)	Chemical	Gene	START_ENTITY|parataxis|independent independent|nsubj|inhibitor inhibitor|nmod|mTOR mTOR|appos|END_ENTITY	This orexin/GPCR-stimulated mTOR activation is sensitive to rapamycin , an inhibitor of mTOR complex 1 -LRB- mTORC1 -RRB- but is independent of two well known mTORC1 activators , Erk and Akt .
25478892	0	rapamycin	142,151	mTORC1	163,169	rapamycin	mTORC1	MESH:D020123	382056(Tax:10090)	Chemical	Gene	functions|amod|START_ENTITY functions|appos|END_ENTITY	Erythroid induction of K562 cells treated with mithramycin is associated with inhibition of raptor gene transcription and mammalian target of rapamycin complex 1 -LRB- mTORC1 -RRB- functions .
25652038	6	rapamycin	1267,1276	mTORC1	1246,1252	rapamycin	mTORC2	MESH:D020123	74343(Tax:10090)	Chemical	Gene	blocks|nmod|START_ENTITY blocks|dobj|inhibition inhibition|amod|END_ENTITY	Further reduction of FKBP12 in cell lines with already low FKBP12 levels completely blocks mTORC1 inhibition by rapamycin , indicating that relative FKBP12 levels are critical for both mTORC1 and mTORC2 inhibition , but at different levels .
26584207	0	rapamycin	76,85	mTORC1	97,103	rapamycin	mTORC1	MESH:D020123	382056(Tax:10090)	Chemical	Gene	target|nmod|START_ENTITY 20-hydroxyecdysone|nmod|target effect|nmod|20-hydroxyecdysone Evaluating|dobj|effect Evaluating|dep|END_ENTITY	Evaluating the effect of 20-hydroxyecdysone -LRB- 20HE -RRB- on mechanistic target of rapamycin complex 1 -LRB- mTORC1 -RRB- signaling in the skeletal muscle and liver of rats .
18672974	0	rapamycin	74,83	mammalian_target_of_rapamycin	18,47	rapamycin	mammalian target of rapamycin	MESH:D020123	2475	Chemical	Gene	Evaluation|nmod|START_ENTITY Evaluation|nmod|pathway pathway|compound|END_ENTITY	Evaluation of the mammalian_target_of_rapamycin pathway and the effect of rapamycin on target expression and cellular proliferation in osteosarcoma cells from dogs .
20977929	0	rapamycin	59,68	mammalian_target_of_rapamycin	18,47	rapamycin	mammalian target of rapamycin	MESH:D020123	2475	Chemical	Gene	pathway|nmod|START_ENTITY pathway|compound|END_ENTITY	Inhibition of the mammalian_target_of_rapamycin pathway by rapamycin blocks cocaine-induced locomotor sensitization .
21092676	0	rapamycin	30,39	mammalian_target_of_rapamycin	58,87	rapamycin	mammalian target of rapamycin	MESH:D020123	2475	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	-LSB- Inhibition of cell growth by rapamycin through targeting mammalian_target_of_rapamycin signaling pathway in nasopharyngeal_carcinoma -RSB- .
22040565	0	rapamycin	56,65	mammalian_target_of_rapamycin	16,45	rapamycin	mammalian target of rapamycin	MESH:D020123	2475	Chemical	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of mammalian_target_of_rapamycin -LRB- mTOR -RRB- by rapamycin in a murine model of lipopolysaccharide-induced acute_lung_injury .
22913509	0	rapamycin	38,47	mammalian_target_of_rapamycin	51,80	rapamycin	mammalian target of rapamycin	MESH:D020123	2475	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Preventive and therapeutic effects of rapamycin , a mammalian_target_of_rapamycin inhibitor , on food_allergy in mice .
24737099	0	rapamycin	127,136	mammalian_target_of_rapamycin	14,43	rapamycin	mammalian target of rapamycin	MESH:D020123	2475	Chemical	Gene	resistance|compound|START_ENTITY mechanism|nmod|resistance conditions|dep|mechanism decreased|nmod|conditions decreased|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of mammalian_target_of_rapamycin in atherosclerotic_plaques is decreased under diabetic conditions : a mechanism for rapamycin resistance .
26381051	0	rapamycin	58,67	miR-208a	22,30	rapamycin	miR-208a	MESH:D020123	100314162(Tax:10116)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of cardiac miR-208a , an inducer of obesity , by rapamycin and nebivolol .
17620442	0	rapamycin	126,135	p21	95,98	rapamycin	p21	MESH:D020123	1026	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Sensitizing HER2-overexpressing cancer cells to luteolin-induced apoptosis through suppressing p21 -LRB- WAF1/CIP1 -RRB- expression with rapamycin .
11567647	0	rapamycin	18,27	protein_kinase_C_alpha	37,59	rapamycin	protein kinase C alpha	MESH:D020123	5578	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Immunosuppressant rapamycin inhibits protein_kinase_C_alpha and p38_mitogen-activated_protein_kinase leading to the inhibition of chondrogenesis .
23454121	0	rapamycin	22,31	thioredoxin_interacting_protein	63,94	rapamycin	thioredoxin interacting protein	MESH:D020123	10628	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Mechanistic target of rapamycin -LRB- mTOR -RRB- dependent regulation of thioredoxin_interacting_protein -LRB- TXNIP -RRB- transcription in hypoxia .
23030618	0	rasagiline	132,142	AChE	159,163	rasagiline	AChE	MESH:C031967	43	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	3D MI-DRAGON : new model for the reconstruction of US FDA drug - target network and theoretical-experimental studies of inhibitors of rasagiline derivatives for AChE .
10907720	0	rasagiline	13,23	MAO-B	27,32	rasagiline	MAO-B	MESH:C031967	25750(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Studies with rasagiline , a MAO-B inhibitor , in experimental focal ischemia in the rat .
15621213	0	rasagiline	49,59	MAO-B	33,38	rasagiline	MAO-B	MESH:C031967	4129	Chemical	Gene	VK-28|amod|START_ENTITY inhibitor|dobj|VK-28 inhibitor|nsubj|derivatives derivatives|nmod|END_ENTITY	Bifunctional drug derivatives of MAO-B inhibitor rasagiline and iron chelator VK-28 as a more effective approach to treatment of brain ageing and ageing neurodegenerative_diseases .
16110345	0	rasagiline	134,144	MAO-B	95,100	rasagiline	MAO-B	MESH:C031967	4129	Chemical	Gene	START_ENTITY|nsubj|Neuropharmacological Neuropharmacological|appos|properties properties|nmod|drug drug|compound|END_ENTITY	Neuropharmacological , neuroprotective and amyloid precursor processing properties of selective MAO-B inhibitor antiparkinsonian drug , rasagiline .
10082192	0	rasagiline	26,36	monoamine_oxidase-B	50,69	rasagiline	monoamine oxidase-B	MESH:C031967	109731(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Neuroprotective effect of rasagiline , a selective monoamine_oxidase-B inhibitor , against closed_head_injury in the mouse .
15765264	0	rasagiline	26,36	monoamine_oxidase-B	40,59	rasagiline	monoamine oxidase-B	MESH:C031967	25750(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Neuroprotective effect of rasagiline , a monoamine_oxidase-B inhibitor , on spontaneous cell degeneration in a rat model .
26474874	0	rasagiline	122,132	monoamine_oxidase-B	48,67	rasagiline	monoamine oxidase-B	MESH:C031967	4129	Chemical	Gene	comparison|nmod|START_ENTITY pattern|dep|comparison pattern|nmod|inhibitors inhibitors|amod|END_ENTITY	Prescribing pattern and resource utilization of monoamine_oxidase-B inhibitors in Parkinson treatment : comparison between rasagiline and selegiline .
26897020	0	rasagiline	134,144	monoamine_oxidase-B	60,79	rasagiline	monoamine oxidase-B	MESH:C031967	4129	Chemical	Gene	comparison|nmod|START_ENTITY Erratum|dep|comparison Erratum|dep|pattern pattern|nmod|inhibitors inhibitors|amod|END_ENTITY	Erratum to : Prescribing pattern and resource utilization of monoamine_oxidase-B inhibitors in Parkinson treatment : comparison between rasagiline and selegiline .
15339864	0	rasagiline	27,37	monoamine_oxidase_B	89,108	rasagiline	monoamine oxidase B	MESH:C031967	25750(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Cardiovascular activity of rasagiline , a selective and potent inhibitor of mitochondrial monoamine_oxidase_B : comparison with selegiline .
23030609	0	rasagiline	131,141	monoamine_oxidase_B	66,85	rasagiline	monoamine oxidase B	MESH:C031967	4129	Chemical	Gene	bioisosteres|compound|START_ENTITY generation|nmod|bioisosteres techniques|dep|generation techniques|nmod|discovery discovery|nmod|inhibitors inhibitors|compound|END_ENTITY	QSAR and molecular docking techniques for the discovery of potent monoamine_oxidase_B inhibitors : computer-aided generation of new rasagiline bioisosteres .
9559942	0	rasagiline	46,56	monoamine_oxidase_B	60,79	rasagiline	monoamine oxidase B	MESH:C031967	25750(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Increased survival of dopaminergic neurons by rasagiline , a monoamine_oxidase_B inhibitor .
9564628	0	rasagiline	139,149	monoamine_oxidase_B	85,104	rasagiline	monoamine oxidase B	MESH:C031967	708468(Tax:9544)	Chemical	Gene	N-propargyl-1-aminoindan|appos|START_ENTITY production|dep|N-propargyl-1-aminoindan production|nmod|END_ENTITY	Increased striatal dopamine production from L-DOPA following selective inhibition of monoamine_oxidase_B by R -LRB- + -RRB- - N-propargyl-1-aminoindan -LRB- rasagiline -RRB- in the monkey .
9564630	0	rasagiline	33,43	monoamine_oxidase_B	104,123	rasagiline	monoamine oxidase B	MESH:C031967	4129	Chemical	Gene	N-propargyl-1-aminoindan|appos|START_ENTITY R|dep|N-propargyl-1-aminoindan R|dep|inhibitors inhibitors|nmod|END_ENTITY	-LRB- R -RRB- -LRB- + -RRB- - N-propargyl-1-aminoindan -LRB- rasagiline -RRB- and derivatives : highly selective and potent inhibitors of monoamine_oxidase_B .
15628826	0	rasagiline	64,74	monoamine_oxidase_type_B	114,138	rasagiline	monoamine oxidase type B	MESH:C031967	4129	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|amod|END_ENTITY	Tolerability , safety , pharmacodynamics , and pharmacokinetics of rasagiline : a potent , selective , and irreversible monoamine_oxidase_type_B inhibitor .
24447649	0	rasagiline	18,28	monoamine_oxidase_type_B	42,66	rasagiline	monoamine oxidase type B	MESH:C031967	4129	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Cardiac safety of rasagiline , a selective monoamine_oxidase_type_B inhibitor for the treatment of Parkinson 's _ disease : a thorough QT/QTc study .
6318774	0	razoxane	15,23	TIMP	83,87	razoxane	TIMP	MESH:D011929	7076	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	The effects of razoxane -LRB- ICRF_159 -RRB- on the production of collagenase and inhibitor -LRB- TIMP -RRB- by stimulated rabbit articular chondrocytes .
11046075	0	rebamipide	55,65	cyclooxygenase-2	13,29	rebamipide	cyclooxygenase-2	MESH:C052785	29527(Tax:10116)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of cyclooxygenase-2 in rat gastric_mucosa by rebamipide , a mucoprotective agent .
12162853	0	rebamipide	52,62	cytochrome_P450	15,30	rebamipide	cytochrome P450	MESH:C052785	4051	Chemical	Gene	metabolism|nmod|START_ENTITY END_ENTITY|nmod|metabolism	Involvement of cytochrome_P450 in the metabolism of rebamipide by the human liver .
12678329	0	rebamipide	10,20	hepatocyte_growth_factor	82,106	rebamipide	hepatocyte growth factor	MESH:C052785	24446(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|involvement involvement|nmod|END_ENTITY	Effect of rebamipide on acetic_acid-induced gastric_ulcer in rats : involvement of hepatocyte_growth_factor .
16039106	0	rebamipide	26,36	mucin	71,76	rebamipide	mucin	MESH:C052785	65202(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|production production|compound|END_ENTITY	The inhibitory effects of rebamipide on cigarette smoke-induced airway mucin production .
15609068	0	reboxetine	44,54	Fos	12,15	reboxetine	Fos	MESH:C074679	314322(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY expression|acl|induced expression|compound|END_ENTITY	Contrasting Fos expression induced by acute reboxetine and fluoxetine in the rat forebrain : neuroanatomical substrates for the antidepressant effect .
26539877	0	reboxetine	11,21	carboxypeptidase_E	37,55	reboxetine	carboxypeptidase E	MESH:C074679	25669(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	-LSB- Effect of reboxetine on activity of carboxypeptidase_E in the nerve tissue of rats -RSB- .
20064607	0	reduced_glutathione	54,73	glutathione_S-transferase	8,33	reduced glutathione	glutathione S-transferase	MESH:D005978	54486(Tax:10090)	Chemical	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	Mutated glutathione_S-transferase in combination with reduced_glutathione shows a synergistic effect in ameliorating oxidative stress and airway_inflammation .
2112914	0	reduced_glutathione	25,44	insulin	12,19	reduced glutathione	insulin	MESH:D005978	3630	Chemical	Gene	Reaction|nmod|START_ENTITY Reaction|nmod|END_ENTITY	Reaction of insulin with reduced_glutathione .
26554440	0	regadenoson	35,46	AMPD1	0,5	regadenoson	AMPD1	MESH:C430916	270	Chemical	Gene	polymorphism|nmod|START_ENTITY polymorphism|compound|END_ENTITY	AMPD1 polymorphism and response to regadenoson .
17112296	0	regadenoson	57,68	adenosine_A2A-receptor	73,95	regadenoson	adenosine A2A-receptor	MESH:C430916	135	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	A population pharmacokinetic/pharmacodynamic analysis of regadenoson , an adenosine_A2A-receptor agonist , in healthy male volunteers .
17577101	0	regadenoson	97,108	adenosine_A2A_receptor	129,151	regadenoson	adenosine A2A receptor	MESH:C430916	403960(Tax:9615)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Caffeine attenuates the duration of coronary vasodilation and changes in hemodynamics induced by regadenoson -LRB- CVT-3146 -RRB- , a novel adenosine_A2A_receptor agonist .
18513639	0	regadenoson	10,21	adenosine_A2A_receptor	26,48	regadenoson	adenosine A2A receptor	MESH:C430916	135	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Safety of regadenoson , an adenosine_A2A_receptor agonist for myocardial perfusion imaging , in mild asthma and moderate asthma patients : a randomized , double-blind , placebo-controlled trial .
22067143	0	regadenoson	79,90	adenosine_A2A_receptor	104,126	regadenoson	adenosine A2A receptor	MESH:C430916	403960(Tax:9615)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Detection of coronary_stenosis with myocardial contrast echocardiography using regadenoson , a selective adenosine_A2A_receptor agonist .
25071018	0	regorafenib	21,32	SHP-1	0,5	regorafenib	SHP-1	MESH:C559147	5777	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	SHP-1 is a target of regorafenib in colorectal_cancer .
25544765	0	regorafenib	25,36	protein_kinase_D	57,73	regorafenib	protein kinase D	MESH:C559147	5587	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|inhibition inhibition|amod|END_ENTITY	The cytotoxic effects of regorafenib in combination with protein_kinase_D inhibition in human colorectal_cancer cells .
17062925	0	reinioside_C	22,34	LOX-1	38,43	reinioside C	LOX-1	MESH:C530274	4973	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	-LSB- Inhibitory effect of reinioside_C on LOX-1 expression induced by ox-LDL -RSB- .
23668634	0	remogliflozin_etabonate	39,62	SGLT2	123,128	remogliflozin etabonate	SGLT2	MESH:C532127	6524	Chemical	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	First human dose-escalation study with remogliflozin_etabonate , a selective inhibitor of the sodium-glucose transporter 2 -LRB- SGLT2 -RRB- , in healthy subjects and in subjects with type_2_diabetes_mellitus .
7636755	0	remoxipride	24,35	Prolactin	0,9	remoxipride	Prolactin	MESH:D017330	5617	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|END_ENTITY	Prolactin release after remoxipride by an integrated pharmacokinetic-pharmacodynamic model with intra - and interindividual aspects .
11607043	0	remoxipride	43,54	dopamine_D2_receptor	58,78	remoxipride	dopamine D2 receptor	MESH:D017330	1813	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Pharmacology of the atypical antipsychotic remoxipride , a dopamine_D2_receptor antagonist .
1688013	0	remoxipride	25,36	prolactin	68,77	remoxipride	prolactin	MESH:D017330	5617	Chemical	Gene	concentrations|nmod|START_ENTITY concentrations|nmod|relation relation|nmod|END_ENTITY	Plasma concentrations of remoxipride and haloperidol in relation to prolactin and short-term therapeutic outcome in schizophrenic patients .
2885345	0	remoxipride	33,44	prolactin	96,105	remoxipride	prolactin	MESH:D017330	5617	Chemical	Gene	trial|nmod|START_ENTITY II|dobj|trial II|nmod|measurements measurements|nmod|activity activity|amod|END_ENTITY	Early phase II clinical trial of remoxipride in treatment of schizophrenia with measurements of prolactin and neuroleptic activity .
7669486	0	remoxipride	60,71	prolactin	36,45	remoxipride	prolactin	MESH:D017330	5617	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|Influence Influence|nmod|interval interval|nmod|END_ENTITY	Influence of the dosing interval on prolactin release after remoxipride .
18187595	0	repaglinide	90,101	SLCO1B1	21,28	repaglinide	SLCO1B1	MESH:C072379	10599	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY polymorphism|nmod|pharmacokinetics polymorphism|nsubj|effects effects|nmod|END_ENTITY	Different effects of SLCO1B1 polymorphism on the pharmacokinetics and pharmacodynamics of repaglinide and nateglinide .
12482641	0	repaglinide	14,25	insulin	29,36	repaglinide	insulin	MESH:C072379	3630	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	The effect of repaglinide on insulin secretion and oxidative stress in type 2 diabetic patients .
14632720	0	repaglinide	14,25	insulin	73,80	repaglinide	insulin	MESH:C072379	3630	Chemical	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|END_ENTITY	Comparison of repaglinide vs. gliclazide in combination with bedtime NPH insulin in patients with Type 2 diabetes inadequately controlled with oral hypoglycaemic agents .
17211567	0	repaglinide	12,23	insulin	127,134	repaglinide	insulin	MESH:C072379	3630	Chemical	Gene	decreases|compound|START_ENTITY exogenous|nsubj|decreases exogenous|nmod|patients patients|acl|taking taking|dobj|treatment treatment|compound|END_ENTITY	Preprandial repaglinide decreases exogenous insulin requirements and HbA1c levels in type 2 diabetic patients taking intensive insulin treatment .
17211567	0	repaglinide	12,23	insulin	44,51	repaglinide	insulin	MESH:C072379	3630	Chemical	Gene	decreases|compound|START_ENTITY exogenous|nsubj|decreases exogenous|dobj|requirements requirements|compound|END_ENTITY	Preprandial repaglinide decreases exogenous insulin requirements and HbA1c levels in type 2 diabetic patients taking intensive insulin treatment .
17211567	10	repaglinide	1249,1260	insulin	1274,1281	repaglinide	insulin	MESH:C072379	3630	Chemical	Gene	START_ENTITY|nmod|therapy therapy|compound|END_ENTITY	Combining repaglinide to intensive insulin therapy could be a safe and effective alternative to intensive insulin therapy alone for the glycemic control and for reducing exogenous insulin requirements in type 2 diabetic patients .
18166815	0	repaglinide	62,73	insulin	40,47	repaglinide	insulin	MESH:C072379	3630	Chemical	Gene	Impact|amod|START_ENTITY Impact|nmod|END_ENTITY	Impact of metformin versus the prandial insulin secretagogue , repaglinide , on fasting and postprandial glucose and lipid responses in non-obese patients with type 2 diabetes .
18777156	0	repaglinide	128,139	insulin	81,88	repaglinide	insulin	MESH:C072379	3630	Chemical	Gene	aspart|nmod|START_ENTITY aspart|compound|END_ENTITY	Differential lipid profile and hormonal response in type 2 diabetes by exogenous insulin aspart versus the insulin secretagogue repaglinide , at the same glycemic control .
20305679	0	repaglinide	46,57	insulin	70,77	repaglinide	insulin	MESH:C072379	3630	Chemical	Gene	efficacy|amod|START_ENTITY efficacy|nmod|resistance resistance|compound|END_ENTITY	A variation in NOS1AP gene is associated with repaglinide efficacy on insulin resistance in type 2 diabetes of Chinese .
10729376	0	reserpine	11,20	LDL_receptor	42,54	reserpine	LDL receptor	MESH:D012110	100009086(Tax:9986)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of reserpine on expression of the LDL_receptor in liver and on plasma and tissue lipids , low density lipoprotein and fibrinogen in rabbits in vivo .
1713314	0	reserpine	69,78	Neuropeptide	0,12	reserpine	Neuropeptide	MESH:D012110	379044(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY regulation|dep|effect regulation|compound|END_ENTITY	Neuropeptide Y mRNA regulation in rat sympathetic ganglia : effect of reserpine .
6116608	0	reserpine	27,36	Prolactin	0,9	reserpine	Prolactin	MESH:D012110	5617	Chemical	Gene	treatment|amod|START_ENTITY secretion|nmod|treatment secretion|nsubj|END_ENTITY	Prolactin secretion during reserpine and syrosingopine treatment .
1684370	0	reserpine	72,81	Tyrosine_hydroxylase	0,20	reserpine	Tyrosine hydroxylase	MESH:D012110	25085(Tax:10116)	Chemical	Gene	evoked|nmod|START_ENTITY evoked|nsubj|inductions inductions|amod|END_ENTITY	Tyrosine_hydroxylase and dopamine beta-hydroxylase inductions evoked by reserpine in the superior cervical ganglion of developing eu - and hypothyroid rats .
1705056	0	reserpine	96,105	Tyrosine_hydroxylase	0,20	reserpine	Tyrosine hydroxylase	MESH:D012110	7054	Chemical	Gene	administration|amod|START_ENTITY increased|nmod|administration coeruleus|ccomp|increased coeruleus|nsubj|levels levels|amod|END_ENTITY	Tyrosine_hydroxylase and galanin mRNA levels in locus coeruleus neurons are increased following reserpine administration .
1976760	0	reserpine	104,113	Tyrosine_hydroxylase	0,20	reserpine	Tyrosine hydroxylase	MESH:D012110	7054	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|concentration concentration|amod|END_ENTITY	Tyrosine_hydroxylase mRNA concentration in midbrain dopaminergic neurons is differentially regulated by reserpine .
4152852	0	reserpine	10,19	catechol-O-methyl_transferase	23,52	reserpine	catechol-O-methyl transferase	MESH:D012110	24267(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of reserpine on catechol-O-methyl_transferase in rat submaxillary gland .
708472	0	reserpine	10,19	monoamine_oxidase	27,44	reserpine	monoamine oxidase	MESH:D012110	29253(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	Effect of reserpine on the monoamine_oxidase -LRB- MAO -RRB- activity in rat liver and brain .
1850078	0	reserpine	10,19	neuropeptide	38,50	reserpine	neuropeptide	MESH:D012110	379044(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|amod|END_ENTITY	Effect of reserpine and colchicine on neuropeptide mRNA levels in the rat hypothalamic paraventricular nucleus .
22891581	0	reserpine	140,149	neurotensin	51,62	reserpine	neurotensin	MESH:D012110	299757(Tax:10116)	Chemical	Gene	-RSB-|amod|START_ENTITY background|nmod|-RSB- microinjection|nmod|background microinjection|nsubj|Reproduction Reproduction|nmod|reactions reactions|nmod|END_ENTITY	-LSB- Reproduction of passive avoidance reactions after neurotensin microinjection into nucleus accumbens of rat brain against the background of reserpine action -RSB- .
20504635	0	reserpine	11,20	phenylethanolamine_N-methyltransferase	24,62	reserpine	phenylethanolamine N-methyltransferase	MESH:D012110	24661(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	Effects of reserpine on phenylethanolamine_N-methyltransferase mRNA levels in rat adrenal gland : Role of steroids .
2903502	0	reserpine	171,180	phenylethanolamine_N-methyltransferase	35,73	reserpine	phenylethanolamine N-methyltransferase	MESH:D012110	24661(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY expression|dep|effects expression|nmod|END_ENTITY	Coexistence and gene expression of phenylethanolamine_N-methyltransferase , tyrosine_hydroxylase , and neuropeptide_tyrosine in the rat and bovine adrenal gland : effects of reserpine .
131202	0	reserpine	34,43	prolactin	10,19	reserpine	prolactin	MESH:D012110	5617	Chemical	Gene	treatment|amod|START_ENTITY levels|nmod|treatment levels|compound|END_ENTITY	Increased prolactin levels during reserpine treatment of hypertensive patients .
1473523	0	reserpine	10,19	prolactin	41,50	reserpine	prolactin	MESH:D012110	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Effect of reserpine on the inhibition of prolactin released from different pituitary constructs in vitro by dopamine , bromocriptine and apomorphine .
6722826	0	reserpine	11,20	prolactin	24,33	reserpine	prolactin	MESH:D012110	5617	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Effects of reserpine on prolactin levels and incidence of breast_cancer in postmenopausal women .
7248756	0	reserpine	21,30	prolactin	43,52	reserpine	prolactin	MESH:D012110	24683(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|glands glands|amod|vitro vitro|nmod|release release|compound|END_ENTITY	The direct effect of reserpine in vitro on prolactin release from rat anterior pituitary glands .
15837122	0	reserpine	24,33	ret	17,20	reserpine	ret	MESH:D012110	24716(Tax:10116)	Chemical	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|END_ENTITY	Up-regulation of ret by reserpine in the adult rat adrenal medulla .
8369965	0	reserpine	17,26	tryptophan_hydroxylase	30,52	reserpine	tryptophan hydroxylase	MESH:D012110	24848(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activity activity|amod|END_ENTITY	Acute effects of reserpine on tryptophan_hydroxylase activity and mRNA in rat brain .
11161478	0	reserpine	97,106	tyrosine_hydroxylase	31,51	reserpine	tyrosine hydroxylase	MESH:D012110	25085(Tax:10116)	Chemical	Gene	stimulation|amod|START_ENTITY involved|nmod|stimulation involved|nmod|stability stability|amod|END_ENTITY	Multiple complexes involved in tyrosine_hydroxylase mRNA stability in rat adrenal medulla , after reserpine stimulation .
1350653	0	reserpine	11,20	tyrosine_hydroxylase	24,44	reserpine	tyrosine hydroxylase	MESH:D012110	7054	Chemical	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	Effects of reserpine on tyrosine_hydroxylase mRNA levels in locus coeruleus and medullary A1 and A2 neurons analyzed by in situ hybridization histochemistry and quantitative image analysis methods .
14767	0	reserpine	31,40	tyrosine_hydroxylase	96,116	reserpine	tyrosine hydroxylase	MESH:D012110	395592(Tax:9031)	Chemical	Gene	dose|nmod|START_ENTITY effect|nmod|dose administered|nsubj|effect administered|nmod|development development|nmod|activity activity|amod|END_ENTITY	The effect of a single dose of reserpine administered prior to incubation on the development of tyrosine_hydroxylase activity in chick sympathetic ganglia .
20504418	0	reserpine	75,84	tyrosine_hydroxylase	32,52	reserpine	tyrosine hydroxylase	MESH:D012110	25085(Tax:10116)	Chemical	Gene	elicited|nmod|START_ENTITY induction|acl|elicited induction|amod|END_ENTITY	Further characterization of the tyrosine_hydroxylase induction elicited by reserpine in the rat locus coeruleus and adrenals .
2865664	0	reserpine	74,83	tyrosine_hydroxylase	42,62	reserpine	tyrosine hydroxylase	MESH:D012110	25085(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|properties properties|nmod|END_ENTITY	Molecular and physiological properties of tyrosine_hydroxylase induced by reserpine in rat adrenal gland .
6138264	0	reserpine	76,85	tyrosine_hydroxylase	10,30	reserpine	tyrosine hydroxylase	MESH:D012110	25085(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY neurons|nmod|treatment neurons|nsubj|activity activity|amod|END_ENTITY	Increased tyrosine_hydroxylase activity in central adrenaline neurons after reserpine treatment .
23765438	0	resistin	18,26	TNF-a	82,87	resistin	TNF-a	MESH:D052243	24835(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|nmod|END_ENTITY	The adipocytokine resistin stimulates the production of proinflammatory cytokines TNF-a and IL-6 in pancreatic acinar cells via NF-kB activation .
24174713	0	resolvin_D1	23,34	cyclooxygenase-2	52,68	resolvin D1	cyclooxygenase-2	MESH:C518399	5743	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Novel biphasic role of resolvin_D1 on expression of cyclooxygenase-2 in lipopolysaccharide-stimulated lung fibroblasts is partly through PI3K/AKT and ERK2 pathways .
19860733	0	resorcyclic_acid_lactones	22,47	Hsp90	0,5	resorcyclic acid lactones	Hsp90	null	3320	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|END_ENTITY	Hsp90 inhibition with resorcyclic_acid_lactones -LRB- RALs -RRB- .
20087915	0	resorcylic_acid_macrolactone	50,78	Hsp90	93,98	resorcylic acid macrolactone	Hsp90	null	3320	Chemical	Gene	START_ENTITY|dobj|inhibitors inhibitors|nmod|END_ENTITY	Targeting the Hsp90 chaperone : synthesis of novel resorcylic_acid_macrolactone inhibitors of Hsp90 .
24933654	0	resveratrol	28,39	ATM	21,24	resveratrol	ATM	MESH:C059514	472	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Direct activation of ATM by resveratrol under oxidizing conditions .
24413998	0	resveratrol	14,25	AdipoR1	47,54	resveratrol	AdipoR1	MESH:C059514	289036(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|nmod|END_ENTITY	The effect of resveratrol on the expression of AdipoR1 in kidneys of diabetic_nephropathy .
21221775	0	resveratrol	15,26	BDNF	34,38	resveratrol	BDNF	MESH:C059514	24225(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of oral resveratrol on the BDNF gene expression in the hippocampus of the rat brain .
15345477	0	resveratrol	37,48	Bcl-2	73,78	resveratrol	Bcl-2	MESH:C059514	24224(Tax:10116)	Chemical	Gene	preconditioning|nmod|START_ENTITY preconditioning|dep|role role|nmod|END_ENTITY	Pharmacological preconditioning with resveratrol : role of CREB-dependent Bcl-2 signaling via adenosine A3 receptor activation .
19426672	0	resveratrol	8,19	Bcl-2	78,83	resveratrol	Bcl-2	MESH:C059514	596	Chemical	Gene	derivative|amod|START_ENTITY overcomes|nsubj|derivative overcomes|ccomp|conferred conferred|nmod|END_ENTITY	A novel resveratrol derivative , HS1793 , overcomes the resistance conferred by Bcl-2 in human leukemic U937 cells .
19885558	0	resveratrol	8,19	Bcl-2	85,90	resveratrol	Bcl-2	MESH:C059514	596	Chemical	Gene	treatment|amod|START_ENTITY overcomes|nsubj|treatment overcomes|ccomp|conferred conferred|nmod|END_ENTITY	A novel resveratrol analogue HS-1793 treatment overcomes the resistance conferred by Bcl-2 and is associated with the formation of mature PML nuclear bodies in renal_clear_cell_carcinoma Caki-1 cells .
22148982	0	resveratrol	10,21	Bcl-2	25,30	resveratrol	Bcl-2	MESH:C059514	24224(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of resveratrol on Bcl-2 and VEGF expression in oxygen-induced retinopathy_of_prematurity .
10668496	2	resveratrol	282,293	COX-2	393,398	resveratrol	COX-2	MESH:C059514	5743	Chemical	Gene	suppress|nsubj|START_ENTITY suppress|dobj|phorbol_ester phorbol_ester|dep|induction induction|nmod|END_ENTITY	In this study , we investigated whether resveratrol , a chemopreventive agent found in grapes , could suppress phorbol_ester -LRB- PMA -RRB- - mediated induction of COX-2 in human mammary and oral epithelial cells .
18814970	0	resveratrol	26,37	COX-2	110,115	resveratrol	COX-2	MESH:C059514	26198(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|effect effect|acl|related related|nmod|impairment impairment|compound|END_ENTITY	Antinociceptive effect of resveratrol in carrageenan-evoked hyperalgesia in rats : prolonged effect related to COX-2 expression impairment .
11597580	0	resveratrol	90,101	CYP1A1	69,75	resveratrol	CYP1A1	MESH:C059514	1543	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|mechanism mechanism|nmod|inhibition inhibition|nmod|expression expression|compound|END_ENTITY	Involvement of a post-transcriptional mechanism in the inhibition of CYP1A1 expression by resveratrol in breast_cancer cells .
16488535	0	resveratrol	23,34	ErbB2	56,61	resveratrol	ErbB2	MESH:C059514	2064	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|nmod|END_ENTITY	Bifunctional effect of resveratrol on the expression of ErbB2 in human breast_cancer cell .
25126945	0	resveratrol	30,41	FANCA	13,18	resveratrol	FANCA	MESH:C059514	2175	Chemical	Gene	cells|nmod|START_ENTITY cells|compound|END_ENTITY	Treatment of FANCA cells with resveratrol and N-acetylcysteine : a comparative study .
19740748	0	resveratrol	85,96	FoxO1	0,5	resveratrol	FoxO1	MESH:C059514	2308	Chemical	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	FoxO1 and HNF-4 are involved in regulation of hepatic glucokinase gene expression by resveratrol .
22733486	0	resveratrol	14,25	FoxO1	29,34	resveratrol	FoxO1	MESH:C059514	84482(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|amod|END_ENTITY	The effect of resveratrol on FoxO1 expression in kidneys of diabetic_nephropathy rats .
26556864	0	resveratrol	26,37	GSK3b	121,126	resveratrol	GSK3b	MESH:C059514	2932	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Chemopreventive effect of resveratrol and apocynin on pancreatic carcinogenesis via modulation of nuclear phosphorylated GSK3b and ERK1/2 .
17919812	0	resveratrol	81,92	HIF-1alpha	29,39	resveratrol	HIF-1alpha	MESH:C059514	3091	Chemical	Gene	inhibition|nmod|START_ENTITY END_ENTITY|dep|inhibition	Hypoxia enhances LPA-induced HIF-1alpha and VEGF expression : their inhibition by resveratrol .
17015251	0	resveratrol	27,38	HO-1	43,47	resveratrol	HO-1	MESH:C059514	24451(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Cardioprotective effect of resveratrol via HO-1 expression involves p38 map kinase and PI-3-kinase signaling , but does not involve NFkappaB .
23724044	0	resveratrol	33,44	HSP27	54,59	resveratrol	HSP27	MESH:C059514	3315	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Proteomic profiling reveals that resveratrol inhibits HSP27 expression and sensitizes breast_cancer cells to doxorubicin therapy .
25860916	0	resveratrol	69,80	HSP70	28,33	resveratrol	HSP70	MESH:C059514	15511(Tax:10090)	Chemical	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	Mesenchymal stem cell-based HSP70 promoter-driven VEGFA induction by resveratrol promotes angiogenesis in a mouse model .
26243699	0	resveratrol	69,80	HSP70	28,33	resveratrol	HSP70	MESH:C059514	15511(Tax:10090)	Chemical	Gene	alleviates|amod|START_ENTITY induction|nmod|alleviates induction|compound|END_ENTITY	Mesenchymal stem cell-based HSP70 promoter-driven VEGFA induction by resveratrol alleviates elastase-induced emphysema in a mouse model .
26243699	0	resveratrol	69,80	HSP70	28,33	resveratrol	HSP70	MESH:C059514	15511(Tax:10090)	Chemical	Gene	alleviates|amod|START_ENTITY induction|nmod|alleviates induction|compound|END_ENTITY	Mesenchymal stem cell-based HSP70 promoter-driven VEGFA induction by resveratrol alleviates elastase-induced emphysema in a mouse model .
20090934	0	resveratrol	41,52	Hsp70	130,135	resveratrol	Hsp70	MESH:C059514	3308	Chemical	Gene	results|amod|START_ENTITY results|nmod|downregulation downregulation|nmod|END_ENTITY	Modulation of Akt and ERK1/2 pathways by resveratrol in chronic_myelogenous_leukemia -LRB- CML -RRB- cells results in the downregulation of Hsp70 .
24630009	0	resveratrol	22,33	IL-1b	51,56	resveratrol	IL-1b	MESH:C059514	3553	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	-LSB- Inhibitory effect of resveratrol on expression of IL-1b in mesenchymal stem cells exposed to radiation -RSB- .
12765200	0	resveratrol	42,53	IL-8	15,19	resveratrol	IL-8	MESH:C059514	3576	Chemical	Gene	transcription|nmod|START_ENTITY transcription|compound|END_ENTITY	Suppression of IL-8 gene transcription by resveratrol in phorbol_ester treated human monocytic cells .
19938227	0	resveratrol	28,39	IL-8	57,61	resveratrol	IL-8	MESH:C059514	3576	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|production production|compound|END_ENTITY	Anti-inflammatory effect of resveratrol by inhibition of IL-8 production in LPS-induced THP-1 cells .
18291098	0	resveratrol	28,39	MCP-1	61,66	resveratrol	MCP-1	MESH:C059514	6347	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|compound|END_ENTITY	Anti-inflammatory effect of resveratrol on TNF-alpha-induced MCP-1 expression in adipocytes .
21419119	0	resveratrol	156,167	MCP-1	52,57	resveratrol	MCP-1	MESH:C059514	6347	Chemical	Gene	inhibition|nmod|START_ENTITY END_ENTITY|dep|inhibition	Extracellular HIV-1 Tat upregulates TNF-a dependent MCP-1 / CCL2 production via activation of ERK1/2 pathway in rat hippocampal slice cultures : inhibition by resveratrol , a polyphenolic_phytostilbene .
21878744	11	resveratrol	1370,1381	MCP-1	1425,1430	resveratrol	MCP-1	MESH:C059514	6347	Chemical	Gene	treatment|nmod|START_ENTITY inhibited|nsubj|treatment inhibited|nmod|END_ENTITY	In monocytic cells , treatment with resveratrol significantly inhibited chemotaxis towards MCP-1 already at 1 mol/L .
23661232	0	resveratrol	22,33	MCP-1	37,42	resveratrol	MCP-1	MESH:C059514	6347	Chemical	Gene	START_ENTITY|nmod|IL-6 IL-6|compound|END_ENTITY	Inhibitory effects of resveratrol on MCP-1 , IL-6 , and IL-8 production in human coronary artery smooth muscle cells .
26221511	0	resveratrol	14,25	MDR1	47,51	resveratrol	MDR1	MESH:C059514	5243	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	The effect of resveratrol on the expression of MDR1 gene in leukemic lymphoblast 's of acute_lymphoblastic_leukemia patients .
26221511	0	resveratrol	14,25	MDR1	47,51	resveratrol	MDR1	MESH:C059514	5243	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	The effect of resveratrol on the expression of MDR1 gene in leukemic lymphoblast 's of acute_lymphoblastic_leukemia patients .
18167310	0	resveratrol	63,74	MnSOD	114,119	resveratrol	MnSOD	MESH:C059514	6648	Chemical	Gene	induced|nmod|START_ENTITY resistance|acl|induced mechanisms|nmod|resistance mechanisms|dep|induction induction|nmod|END_ENTITY	Molecular mechanisms of oxidative stress resistance induced by resveratrol : Specific and progressive induction of MnSOD .
18486604	0	resveratrol	8,19	MnSOD	45,50	resveratrol	MnSOD	MESH:C059514	20656(Tax:10090)	Chemical	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	Dietary resveratrol administration increases MnSOD expression and activity in mouse brain .
17724663	0	resveratrol	30,41	Mrp2	86,90	resveratrol	Mrp2	MESH:C059514	25303(Tax:10116)	Chemical	Gene	Metabolism|nmod|START_ENTITY Metabolism|dep|role role|nmod|END_ENTITY	Metabolism and disposition of resveratrol in the isolated perfused rat liver : role of Mrp2 in the biliary excretion of glucuronides .
20068143	14	resveratrol	1766,1777	NAMPT	1732,1737	resveratrol	SIRT1	MESH:C059514	23411	Chemical	Gene	prevented|nmod|START_ENTITY prevented|nsubjpass|effects effects|nmod|END_ENTITY	Glucose - and palmitate-mediated effects on NAMPT and SIRT1 were prevented by resveratrol in vitro .
12659672	0	resveratrol	104,115	NF-kappaB	61,70	resveratrol	NF-kappaB	MESH:C059514	4790	Chemical	Gene	keratinocytes|nmod|START_ENTITY Suppression|nmod|keratinocytes Suppression|nmod|END_ENTITY	Suppression of ultraviolet B exposure-mediated activation of NF-kappaB in normal human keratinocytes by resveratrol .
12716675	7	resveratrol	1845,1856	NF-kappaB	1910,1919	resveratrol	NF-kappaB	MESH:C059514	4790	Chemical	Gene	treatment|amod|START_ENTITY inhibit|nsubj|treatment inhibit|dobj|appearance appearance|nmod|END_ENTITY	CONCLUSIONS : Acute resveratrol treatment does not inhibit the nuclear appearance of NF-kappaB in human umbilical vein endothelial cells , but overnight treatment does .
15476852	0	resveratrol	38,49	NF-kappaB	51,60	resveratrol	NF-kappaB	MESH:C059514	4790	Chemical	Gene	chemoprevention|nmod|START_ENTITY basis|nmod|chemoprevention basis|dep|END_ENTITY	Molecular basis of chemoprevention by resveratrol : NF-kappaB and AP-1 as potential targets .
15588712	5	resveratrol	1100,1111	NF-kappaB	943,952	resveratrol	NF-kappaB	MESH:C059514	4790	Chemical	Gene	suggesting|nmod|START_ENTITY reduced|advcl|suggesting reduced|nsubj|deletion deletion|nmod|sites sites|amod|END_ENTITY	Additionally , the results of our study showed that nuclear_factor-kappa_B -LRB- NF-kappaB -RRB- inhibitors eliminated resveratrol-mediated HO-1 induction and promoter activity , and that deletion of NF-kappaB binding sites in the HO-1 promoter region strongly reduced promoter activity , suggesting involvement of the NF-kappaB pathway in HO-1 induction by resveratrol .
16178859	0	resveratrol	37,48	NF-kappaB	15,24	resveratrol	NF-kappaB	MESH:C059514	4790	Chemical	Gene	Enhancement|nmod|START_ENTITY Enhancement|nmod|activity activity|amod|END_ENTITY	Enhancement of NF-kappaB activity by resveratrol in cytokine-exposed mesangial cells .
24667915	0	resveratrol	82,93	Nampt	58,63	resveratrol	Nampt	MESH:C059514	297508(Tax:10116)	Chemical	Gene	preconditioning|amod|START_ENTITY pools|nmod|preconditioning pools|nmod|END_ENTITY	Protein_kinase_C_epsilon regulates mitochondrial pools of Nampt and NAD following resveratrol and ischemic preconditioning in the rat cortex .
21355597	0	resveratrol	34,45	Nrf2	153,157	resveratrol	Nrf2	MESH:C059514	18024(Tax:10090)	Chemical	Gene	START_ENTITY|acl|induced induced|dobj|tumorigenesis tumorigenesis|nmod|activation activation|nmod|NF-E2-related_factor_2 NF-E2-related_factor_2|appos|END_ENTITY	Pterostilbene is more potent than resveratrol in preventing azoxymethane -LRB- AOM -RRB- - induced colon tumorigenesis via activation of the NF-E2-related_factor_2 -LRB- Nrf2 -RRB- - mediated antioxidant signaling pathway .
25451641	0	resveratrol	47,58	Nrf2	65,69	resveratrol	Nrf2	MESH:C059514	4780	Chemical	Gene	induced|nmod|START_ENTITY stress|acl|induced oxidative|dobj|stress Skin|advcl|oxidative Skin|nmod|END_ENTITY	Skin resistance to oxidative stress induced by resveratrol : From Nrf2 activation to GSH biosynthesis .
26314862	0	resveratrol	163,174	Nrf2	128,132	resveratrol	Nrf2	MESH:C059514	4780	Chemical	Gene	analog|amod|START_ENTITY activation|nmod|analog activation|amod|END_ENTITY	Toward an understanding of the role of a catechol moiety in cancer chemoprevention : The case of copper - _ and_o-quinone-dependent Nrf2 activation by a catechol-type resveratrol analog .
26738390	0	resveratrol	12,23	Nrf2	27,31	resveratrol	Nrf2	MESH:C059514	18024(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|pathway pathway|amod|END_ENTITY	-LSB- Effects of resveratrol on Nrf2 signal pathway of chronic lead-exposed mouse brain tissue -RSB- .
26311624	1	resveratrol	52,63	PAI-1	85,90	resveratrol	PAI-1	MESH:C059514	5054	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|compound|END_ENTITY	Opposite effects of resveratrol on hypoxia-dependent PAI-1 expression in tumour and primary cells .
23874150	0	resveratrol	11,22	PGC-1a	36,42	resveratrol	PGC-1a	MESH:C059514	83516(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|compound|END_ENTITY	Effects of resveratrol and SIRT1 on PGC-1a activity and mitochondrial biogenesis : a reevaluation .
24812624	0	resveratrol	40,51	PTEN	0,4	resveratrol	PTEN	MESH:C059514	5728	Chemical	Gene	effect|nmod|START_ENTITY mediates|dobj|effect mediates|nsubj|END_ENTITY	PTEN mediates the antioxidant effect of resveratrol at nutritionally relevant concentrations .
20133117	0	resveratrol	135,146	Pak1	96,100	resveratrol	Pak1	MESH:C059514	5058	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nmod|effects	Downregulation of cyclin_D1 is associated with decreased levels of p38 MAP kinases , Akt/PKB and Pak1 during chemopreventive effects of resveratrol in liver_cancer cells .
15749705	0	resveratrol	39,50	SIRT1	19,24	resveratrol	SIRT1	MESH:C059514	23411	Chemical	Gene	activation|nmod|START_ENTITY activation|nsubj|Mechanism Mechanism|nmod|END_ENTITY	Mechanism of human SIRT1 activation by resveratrol .
19046567	5	resveratrol	998,1009	SIRT1	1047,1052	resveratrol	SIRT1	MESH:C059514	93759(Tax:10090)	Chemical	Gene	work|nmod|START_ENTITY validates|advcl|work validates|dobj|END_ENTITY	Combined with our previous work on resveratrol , the current study further validates SIRT1 as a target for the treatment of metabolic_disorders and characterizes the mechanisms underlying the therapeutic potential of SIRT1 activation .
20102704	0	resveratrol	100,111	SIRT1	0,5	resveratrol	SIRT1	MESH:C059514	23411	Chemical	Gene	Role|nmod|START_ENTITY eNOS|dep|Role regulates|dobj|eNOS regulates|nsubj|END_ENTITY	SIRT1 regulates oxidant - and cigarette smoke-induced eNOS acetylation in endothelial cells : Role of resveratrol .
20623590	0	resveratrol	25,36	SIRT1	46,51	resveratrol	SIRT1	MESH:C059514	93759(Tax:10090)	Chemical	Gene	activity|nmod|START_ENTITY activity|appos|activator activator|compound|END_ENTITY	Antidiabetic activity of resveratrol , a known SIRT1 activator in a genetic model for type-2 diabetes .
20960276	0	resveratrol	11,22	SIRT1	83,88	resveratrol	SIRT1	MESH:C059514	23411	Chemical	Gene	START_ENTITY|nmod|secretion secretion|acl|stimulated stimulated|nmod|END_ENTITY	Effects of resveratrol on NO secretion stimulated by insulin and its dependence on SIRT1 in high glucose cultured endothelial cells .
21593185	0	resveratrol	20,31	SIRT1	0,5	resveratrol	SIRT1	MESH:C059514	93759(Tax:10090)	Chemical	Gene	ameliorates|amod|START_ENTITY activation|nmod|ameliorates activation|nummod|END_ENTITY	SIRT1 activation by resveratrol ameliorates cisplatin-induced renal_injury through deacetylation of p53 .
21896316	0	resveratrol	22,33	SIRT1	63,68	resveratrol	SIRT1	MESH:C059514	23411	Chemical	Gene	START_ENTITY|nmod|up-regulation up-regulation|nmod|END_ENTITY	Protective effects of resveratrol through the up-regulation of SIRT1 expression in the mutant hSOD1-G93A-bearing motor neuron-like cell culture model of amyotrophic_lateral_sclerosis .
21896928	0	resveratrol	47,58	SIRT1	24,29	resveratrol	SIRT1	MESH:C059514	309757(Tax:10116)	Chemical	Gene	effects|nmod:poss|START_ENTITY essential|nmod|effects essential|nsubj|END_ENTITY	Mediobasal hypothalamic SIRT1 is essential for resveratrol 's effects on insulin action in rats .
21905824	0	resveratrol	10,21	SIRT1	108,113	resveratrol	SIRT1	MESH:C059514	23411	Chemical	Gene	BTM-0512|amod|START_ENTITY Effect|nmod|BTM-0512 Effect|dep|role role|nmod|END_ENTITY	Effect of resveratrol derivative BTM-0512 on high glucose-induced dysfunction of endothelial cells : role of SIRT1 .
22968147	6	resveratrol	828,839	SIRT1	951,956	resveratrol	SIRT1	MESH:C059514	309757(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY decreased|nsubj|secretion decreased|nmod|palmitate palmitate|acl:relcl|abrogated abrogated|nmod|EX527 EX527|appos|inhibitor inhibitor|compound|END_ENTITY	In addition , resveratrol improved glucose-stimulated insulin secretion decreased by palmitate , which was abrogated by EX527 , a specific SIRT1 inhibitor .
23518473	0	resveratrol	23,34	SIRT1	14,19	resveratrol	SIRT1	MESH:C059514	23411	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of SIRT1 by resveratrol requires lamin A.
23583951	0	resveratrol	69,80	SIRT1	8,13	resveratrol	SIRT1	MESH:C059514	23411	Chemical	Gene	transcriptional|nmod|START_ENTITY transcriptional|nsubj|Role Role|nmod|factors factors|compound|END_ENTITY	Role of SIRT1 and FOXO factors in eNOS transcriptional activation by resveratrol .
23918588	0	resveratrol	11,22	SIRT1	84,89	resveratrol	SIRT1	MESH:C059514	23411	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|patients patients|nmod|type_2_diabetes_mellitus type_2_diabetes_mellitus|nmod|expression expression|compound|END_ENTITY	Effects of resveratrol in patients with type_2_diabetes_mellitus on skeletal muscle SIRT1 expression and energy expenditure .
24639483	0	resveratrol	49,60	SIRT1	21,26	resveratrol	SIRT1	MESH:C059514	93759(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|effect effect|nmod|activation activation|compound|END_ENTITY	Modulating effect of SIRT1 activation induced by resveratrol on Foxo1-associated apoptotic signalling in senescent heart .
25737402	0	resveratrol	16,27	SIRT1	105,110	resveratrol	SIRT1	MESH:C059514	93759(Tax:10090)	Chemical	Gene	injection|amod|START_ENTITY prevents|nsubj|injection prevents|advcl|activating activating|dobj|END_ENTITY	Intra-articular resveratrol injection prevents osteoarthritis progression in a mouse model by activating SIRT1 and thereby silencing HIF-2a UNASSIGNED : We investigated the feasibility of the intra-articular injection of resveratrol for preventing the progression of existing cartilage_degeneration in a mouse model of osteoarthritis -LRB- OA -RRB- .
25737402	0	resveratrol	220,231	SIRT1	105,110	resveratrol	SIRT1	MESH:C059514	93759(Tax:10090)	Chemical	Gene	injection|nmod|START_ENTITY feasibility|nmod|injection investigated|dobj|feasibility prevents|parataxis|investigated prevents|advcl|activating activating|dobj|END_ENTITY	Intra-articular resveratrol injection prevents osteoarthritis progression in a mouse model by activating SIRT1 and thereby silencing HIF-2a UNASSIGNED : We investigated the feasibility of the intra-articular injection of resveratrol for preventing the progression of existing cartilage_degeneration in a mouse model of osteoarthritis -LRB- OA -RRB- .
26055805	0	resveratrol	106,117	SIRT1	39,44	resveratrol	SIRT1	MESH:C059514	23411	Chemical	Gene	suppresses|amod|START_ENTITY enhances|nsubj|suppresses Reverse|dep|enhances Reverse|dobj|effects effects|nmod|activators activators|nummod|END_ENTITY	Reverse chemomodulatory effects of the SIRT1 activators resveratrol and SRT1720 in Ewing 's _ sarcoma cells : resveratrol suppresses and SRT1720 enhances etoposide - and vincristine-induced anticancer activity .
26055805	0	resveratrol	56,67	SIRT1	39,44	resveratrol	SIRT1	MESH:C059514	23411	Chemical	Gene	Reverse|nsubj|START_ENTITY Reverse|dobj|effects effects|nmod|activators activators|nummod|END_ENTITY	Reverse chemomodulatory effects of the SIRT1 activators resveratrol and SRT1720 in Ewing 's _ sarcoma cells : resveratrol suppresses and SRT1720 enhances etoposide - and vincristine-induced anticancer activity .
26109052	0	resveratrol	86,97	SIRT1	68,73	resveratrol	SIRT1	MESH:C059514	23411	Chemical	Gene	basis|nmod|START_ENTITY basis|nmod|stimulation stimulation|nmod|activity activity|compound|END_ENTITY	Structural basis for allosteric , substrate-dependent stimulation of SIRT1 activity by resveratrol .
26459286	0	resveratrol	31,42	SIRT1	101,106	resveratrol	SIRT1	MESH:C059514	23411	Chemical	Gene	combinatorial|amod|START_ENTITY alters|nsubj|combinatorial alters|advcl|affecting affecting|dobj|expression expression|compound|END_ENTITY	Epigenetic-based combinatorial resveratrol and pterostilbene alters DNA damage response by affecting SIRT1 and DNMT enzyme expression , including SIRT1-dependent y-H2AX and telomerase regulation in triple-negative breast_cancer .
26525891	7	resveratrol	1154,1165	SIRT1	1059,1064	resveratrol	SIRT1	MESH:C059514	309757(Tax:10116)	Chemical	Gene	activation|nmod|START_ENTITY reversed|nsubj|activation induced|advcl|reversed induced|nsubj|inhibition inhibition|compound|END_ENTITY	Moreover , pharmacological SIRT1 inhibition by Ex527 induced HMGB1 translocation and release , whereas SIRT1 activation by resveratrol or SalB reversed this trend .
26681077	2	resveratrol	319,330	SIRT1	362,367	resveratrol	SIRT1	MESH:C059514	309757(Tax:10116)	Chemical	Gene	START_ENTITY|acl:relcl|activator activator|nmod|END_ENTITY	Our previous studies have shown hepatoprotective effect of polyphenolic compound resveratrol , which is also an activator of SIRT1 .
19796711	0	resveratrol	38,49	STAT3	64,69	resveratrol	STAT3	MESH:C059514	20848(Tax:10090)	Chemical	Gene	Evaluation|nmod|START_ENTITY Evaluation|acl|modulating modulating|dobj|signaling signaling|compound|END_ENTITY	Evaluation of anti-leukemia effect of resveratrol by modulating STAT3 signaling .
17037214	0	resveratrol	12,23	Sirt1	116,121	resveratrol	Sirt1	MESH:C059514	751859(Tax:9823)	Chemical	Gene	Effects|nmod|START_ENTITY preadipocytes|nsubj|Effects preadipocytes|dobj|expression expression|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Effects of resveratrol on pig primary preadipocytes proliferation , differentiation and transcription expression of Sirt1 gene -RSB- .
23524286	0	resveratrol	20,31	Sirt1	0,5	resveratrol	Sirt1	MESH:C059514	23411	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Sirt1 activation by resveratrol is substrate sequence-selective .
24722566	0	resveratrol	42,53	Sirt1	83,88	resveratrol	Sirt1	MESH:C059514	23411	Chemical	Gene	effect|nmod|START_ENTITY hippocampus|nsubj|effect hippocampus|nmod|END_ENTITY	Radioprotective and antioxidant effect of resveratrol in hippocampus by activating Sirt1 .
26872534	0	resveratrol	23,34	Sirt1	0,5	resveratrol	Sirt1	MESH:C059514	309757(Tax:10116)	Chemical	Gene	enhancement|amod|START_ENTITY essential|nmod|enhancement essential|nsubj|END_ENTITY	Sirt1 is essential for resveratrol enhancement of hypoxia-induced autophagy in the type 2 diabetic_nephropathy rat .
25351437	0	resveratrol	59,70	Stat3	21,26	resveratrol	Stat3	MESH:C059514	6774	Chemical	Gene	determinant|nmod|START_ENTITY determinant|nsubj|activation activation|amod|END_ENTITY	GRIM __ -19 - mediated Stat3 activation is a determinant for resveratrol - induced proliferation and cytotoxicity in cervical_tumor - derived cell lines .
18242191	0	resveratrol	50,61	TGF-beta	75,83	resveratrol	TGF-beta	MESH:C059514	7040	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|expression expression|amod|END_ENTITY	A possible link between resveratrol and TGF-beta : resveratrol induction of TGF-beta expression and signaling .
20339855	0	resveratrol	193,204	VEGF	175,179	resveratrol	VEGF	MESH:C059514	7422	Chemical	Gene	secretion|nmod|START_ENTITY END_ENTITY|acl|secretion	Effects of oxysterols on cell viability , inflammatory cytokines , VEGF , and reactive oxygen species production on human retinal cells : cytoprotective effects and prevention of VEGF secretion by resveratrol .
20927579	0	resveratrol	27,38	VEGF	61,65	resveratrol	VEGF	MESH:C059514	7422	Chemical	Gene	effects|nmod|START_ENTITY mediated|nsubj|effects mediated|nmod|END_ENTITY	Anti-angiogenic effects of resveratrol mediated by decreased VEGF and increased TSP1 expression in melanoma-endothelial cell co-culture .
21687947	0	resveratrol	21,32	VEGF	58,62	resveratrol	VEGF	MESH:C059514	7422	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|nmod|gene gene|amod|END_ENTITY	Inhibitory effect of resveratrol on the expression of the VEGF gene and proliferation in renal_cancer cells .
26402726	0	resveratrol	52,63	VEGF	89,93	resveratrol	VEGF	MESH:C059514	7422	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|genes genes|amod|END_ENTITY	Inhibitory effect of cytotoxic stilbenes related to resveratrol on the expression of the VEGF , hTERT and c-Myc genes .
25860916	0	resveratrol	69,80	VEGFA	50,55	resveratrol	VEGFA	MESH:C059514	22339(Tax:10090)	Chemical	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	Mesenchymal stem cell-based HSP70 promoter-driven VEGFA induction by resveratrol promotes angiogenesis in a mouse model .
26243699	0	resveratrol	69,80	VEGFA	50,55	resveratrol	VEGFA	MESH:C059514	22339(Tax:10090)	Chemical	Gene	alleviates|amod|START_ENTITY induction|nmod|alleviates induction|compound|END_ENTITY	Mesenchymal stem cell-based HSP70 promoter-driven VEGFA induction by resveratrol alleviates elastase-induced emphysema in a mouse model .
26243699	0	resveratrol	69,80	VEGFA	50,55	resveratrol	VEGFA	MESH:C059514	22339(Tax:10090)	Chemical	Gene	alleviates|amod|START_ENTITY induction|nmod|alleviates induction|compound|END_ENTITY	Mesenchymal stem cell-based HSP70 promoter-driven VEGFA induction by resveratrol alleviates elastase-induced emphysema in a mouse model .
19321194	0	resveratrol	80,91	Vascular_Endothelial_Growth_Factor	14,48	resveratrol	Vascular Endothelial Growth Factor	MESH:C059514	7422	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of Vascular_Endothelial_Growth_Factor in endometrial_tumour cells by resveratrol and EGCG .
23224687	0	resveratrol	6,17	adiponectin	34,45	resveratrol	adiponectin	MESH:C059514	9370	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Grape resveratrol increases serum adiponectin and downregulates inflammatory genes in peripheral blood mononuclear cells : a triple-blind , placebo-controlled , one-year clinical trial in patients with stable coronary_artery_disease .
26282595	0	resveratrol	15,26	adiponectin	58,69	resveratrol	adiponectin	MESH:C059514	9370	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of resveratrol in crosstalk between adipokine adiponectin and hepatokine fetuin-A in vivo and in vitro .
26282595	0	resveratrol	15,26	adiponectin	58,69	resveratrol	adiponectin	MESH:C059514	9370	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of resveratrol in crosstalk between adipokine adiponectin and hepatokine fetuin-A in vivo and in vitro .
10769659	0	resveratrol	36,47	androgen_receptor	122,139	resveratrol	androgen receptor	MESH:C059514	367	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|nmod|END_ENTITY	Grape-derived chemopreventive agent resveratrol decreases prostate-specific_antigen _ -LRB- PSA -RRB- expression in LNCaP cells by an androgen_receptor -LRB- AR -RRB- - independent mechanism .
19816598	0	resveratrol	22,33	androgen_receptor	37,54	resveratrol	androgen receptor	MESH:C059514	367	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activity activity|compound|END_ENTITY	Repressive effects of resveratrol on androgen_receptor transcriptional activity .
21965742	0	resveratrol	15,26	androgen_receptor	80,97	resveratrol	androgen receptor	MESH:C059514	367	Chemical	Gene	Combination|nmod|START_ENTITY has|nsubj|Combination has|dobj|effect effect|nmod|inhibition inhibition|compound|END_ENTITY	Combination of resveratrol and antiandrogen_flutamide has synergistic effect on androgen_receptor inhibition in prostate_cancer cells .
18543488	0	resveratrol	22,33	angiotensin_II	81,95	resveratrol	angiotensin II	MESH:C059514	24179(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY induced|nsubj|effect induced|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Inhibitory effect of resveratrol on cardiac fibroblast proliferation induced by angiotensin_II -RSB- .
18512326	0	resveratrol	37,48	bcl-2	98,103	resveratrol	bcl-2	MESH:C059514	596	Chemical	Gene	START_ENTITY|nmod|inducting inducting|amod|END_ENTITY	-LSB- Effects of garlic oil combined with resveratrol on inducting of apoptosis and expression of Fas , bcl-2 and bax in human gastric_cancer cell line -RSB- .
17513867	0	resveratrol	102,113	bone_morphogenetic_protein-2	35,63	resveratrol	bone morphogenetic protein-2	MESH:C059514	650	Chemical	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Forkhead proteins are critical for bone_morphogenetic_protein-2 regulation and anti-tumor activity of resveratrol .
24740756	0	resveratrol	122,133	catalase	74,82	resveratrol	catalase	MESH:C059514	24248(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Redox regulation of antioxidant enzymes : post-translational modulation of catalase and glutathione peroxidase activity by resveratrol in diabetic rat liver .
19693696	0	resveratrol	15,26	cyclooxygenase-1	30,46	resveratrol	cyclooxygenase-1	MESH:C059514	24693(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|mRNA mRNA|amod|END_ENTITY	The effects of resveratrol on cyclooxygenase-1 and cyclooxygenase-2 mRNA and protein levels in diabetic_rat_kidneys .
24676467	0	resveratrol	28,39	cyclooxygenase-2	125,141	resveratrol	cyclooxygenase-2	MESH:C059514	29527(Tax:10116)	Chemical	Gene	rats|amod|START_ENTITY effect|nmod|rats function|nsubj|effect function|nmod|reduction reduction|nmod|END_ENTITY	Anti-inflammatory effect of resveratrol on adjuvant_arthritis rats with abnormal immunological function via the reduction of cyclooxygenase-2 and prostaglandin_E2 .
26923138	0	resveratrol	66,77	eIF2a	14,19	resveratrol	eIF2a	MESH:C059514	54318(Tax:10116)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of eIF2a expression and renal_interstitial_fibrosis by resveratrol in rat renal tissue after unilateral_ureteral_obstruction .
14623829	0	resveratrol	68,79	endothelin-1	36,48	resveratrol	endothelin-1	MESH:C059514	1906	Chemical	Gene	strain-induced|nmod|START_ENTITY strain-induced|dobj|expression expression|amod|END_ENTITY	Inhibition of cyclic strain-induced endothelin-1 gene expression by resveratrol .
22634503	0	resveratrol	85,96	epidermal_growth_factor_receptor	30,62	resveratrol	epidermal growth factor receptor	MESH:C059514	1956	Chemical	Gene	signalling|nmod|START_ENTITY pathway|xcomp|signalling pathway|nsubj|Modulation Modulation|nmod|END_ENTITY	Modulation of arsenic-induced epidermal_growth_factor_receptor pathway signalling by resveratrol .
24514079	0	resveratrol	21,32	epidermal_growth_factor_receptor	54,86	resveratrol	epidermal growth factor receptor	MESH:C059514	1956	Chemical	Gene	effect|amod|START_ENTITY effect|nmod|END_ENTITY	In-situ detection of resveratrol inhibition effect on epidermal_growth_factor_receptor of living MCF-7 cells by Atomic Force Microscopy .
20960276	0	resveratrol	11,22	insulin	53,60	resveratrol	insulin	MESH:C059514	3630	Chemical	Gene	START_ENTITY|nmod|secretion secretion|acl|stimulated stimulated|nmod|END_ENTITY	Effects of resveratrol on NO secretion stimulated by insulin and its dependence on SIRT1 in high glucose cultured endothelial cells .
19471118	0	resveratrol	37,48	mTOR	31,35	resveratrol	mTOR	MESH:C059514	21977(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|concentrations concentrations|acl:relcl|inhibit inhibit|dobj|END_ENTITY	At concentrations that inhibit mTOR , resveratrol suppresses cellular senescence .
23272906	0	resveratrol	56,67	mTOR	10,14	resveratrol	mTOR	MESH:C059514	21977(Tax:10090)	Chemical	Gene	potential|nmod|START_ENTITY evaluating|dobj|potential END_ENTITY|dep|evaluating	Targeting mTOR : evaluating the therapeutic potential of resveratrol for cancer treatment .
24060150	0	resveratrol	22,33	mTOR	0,4	resveratrol	mTOR	MESH:C059514	21977(Tax:10090)	Chemical	Gene	targets|nmod|START_ENTITY END_ENTITY|dep|targets	mTOR : more targets of resveratrol ?
16084059	0	resveratrol	10,21	matrix_metalloproteinase-2	25,51	resveratrol	matrix metalloproteinase-2	MESH:C059514	4313	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of resveratrol on matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- and Secreted_Protein_Acidic_and_Rich_in_Cysteine -LRB- SPARC -RRB- on human cultured glioblastoma cells .
18334147	0	resveratrol	12,23	matrix_metalloproteinase-9	27,53	resveratrol	matrix metalloproteinase-9	MESH:C059514	4318	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effects of resveratrol on matrix_metalloproteinase-9 expression in hepatoma cells -RSB- .
24584901	0	resveratrol	22,33	monocyte_chemotactic_protein-1	78,108	resveratrol	monocyte chemotactic protein-1	MESH:C059514	6347	Chemical	Gene	effects|nmod|START_ENTITY mediated|nsubjpass|effects mediated|nmod|proteins proteins|amod|END_ENTITY	Inhibitory effects of resveratrol on foam cell formation are mediated through monocyte_chemotactic_protein-1 and lipid metabolism-related proteins .
24813642	0	resveratrol	15,26	osteoprotegerin	58,73	resveratrol	osteoprotegerin	MESH:C059514	18383(Tax:10090)	Chemical	Gene	Suppression|nmod|START_ENTITY Suppression|nmod|synthesis synthesis|compound|END_ENTITY	Suppression by resveratrol of prostaglandin_D2-stimulated osteoprotegerin synthesis in osteoblasts .
17868048	0	resveratrol	25,36	p38_MAPK	78,86	resveratrol	p38 MAPK	MESH:C059514	26416(Tax:10090)	Chemical	Gene	mechanisms|nmod|START_ENTITY mechanisms|dep|roles roles|nmod|END_ENTITY	Inhibitory mechanisms of resveratrol in platelet activation : pivotal roles of p38_MAPK and NO/cyclic _ GMP .
11745454	6	resveratrol	980,991	p53	1003,1006	resveratrol	Bax	MESH:C059514	581	Chemical	Gene	stimulated|nsubj|START_ENTITY stimulated|dobj|accumulation accumulation|compound|END_ENTITY	When compared with 5-FU , resveratrol stimulated p53 accumulation and activity only weakly and with delayed kinetics and neither the increased levels nor the activity affected apoptosis detectably .
16518869	1	resveratrol	186,197	p53	246,249	resveratrol	p53	MESH:C059514	7157	Chemical	Gene	basis|nmod|START_ENTITY basis|dep|apoptosis apoptosis|acl:relcl|colon_cancer colon_cancer|nmod|four four|dep|+ +|parataxis|Bax Bax|parataxis|/ /|parataxis|+ +|nummod|END_ENTITY	The study investigated the molecular basis of resveratrol -LRB- RSV -RRB- - evoked apoptosis in four -LRB- Bax + / - , Bax - / - , p53 + / + , and p53 - / - -RRB- HCT116 colon_cancer cell lines .
16965847	0	resveratrol	27,38	p53	52,55	resveratrol	p53	MESH:C059514	22060(Tax:10090)	Chemical	Gene	mice|amod|START_ENTITY mice|appos|knockout knockout|compound|END_ENTITY	Oncogenicity evaluation of resveratrol in p53 -LRB- + / - -RRB- -LRB- p53 knockout -RRB- mice .
21225623	0	resveratrol	44,55	p53	14,17	resveratrol	p53	MESH:C059514	7157	Chemical	Gene	proliferation|nmod|START_ENTITY proliferation|compound|END_ENTITY	Regulation of p53 and cell proliferation by resveratrol and its derivatives in breast_cancer cells : an in silico and biochemical approach targeting integrin avb3 .
21593185	0	resveratrol	20,31	p53	100,103	resveratrol	p53	MESH:C059514	22060(Tax:10090)	Chemical	Gene	ameliorates|amod|START_ENTITY activation|nmod|ameliorates cisplatin-induced|nsubj|activation cisplatin-induced|nmod|deacetylation deacetylation|nmod|END_ENTITY	SIRT1 activation by resveratrol ameliorates cisplatin-induced renal_injury through deacetylation of p53 .
15458977	0	resveratrol	50,61	paraoxonase-1	17,30	resveratrol	paraoxonase-1	MESH:C059514	5444	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|expression expression|amod|END_ENTITY	Induction of the paraoxonase-1 gene expression by resveratrol .
15350128	0	resveratrol	57,68	quinone_reductase_2	21,40	resveratrol	quinone reductase 2	MESH:C059514	4835	Chemical	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Crystal structure of quinone_reductase_2 in complex with resveratrol .
18997065	0	resveratrol	68,79	sirtuin_1	8,17	resveratrol	sirtuin 1	MESH:C059514	751859(Tax:9823)	Chemical	Gene	Porcine|nmod|START_ENTITY Porcine|dobj|clone clone|amod|END_ENTITY	Porcine sirtuin_1 gene clone , expression pattern , and regulation by resveratrol .
25004063	0	resveratrol	14,25	sirtuin_1	131,140	resveratrol	sirtuin 1	MESH:C059514	309757(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY role|dep|suppression suppression|nmod|translocation translocation|nmod|upregulation upregulation|nmod|END_ENTITY	Novel role of resveratrol : suppression of high-mobility_group_protein_box_1 nucleocytoplasmic translocation by the upregulation of sirtuin_1 in sepsis-induced liver_injury .
21717185	0	resveratrol	20,31	synthase	32,40	resveratrol	synthase	MESH:C059514	828186(Tax:3702)	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Overexpression of a resveratrol synthase gene -LRB- PcRS -RRB- from Polygonum cuspidatum in transgenic Arabidopsis causes the accumulation of trans-piceid with antifungal activity .
20507262	0	resveratrol	11,22	vascular_endothelial_growth_factor	40,74	resveratrol	vascular endothelial growth factor	MESH:C059514	7422	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of resveratrol on expression of vascular_endothelial_growth_factor in human gingival fibroblasts stimulated by periodontal pathogens .
23205110	0	resveratrol	11,22	vascular_endothelial_growth_factor	26,60	resveratrol	vascular endothelial growth factor	MESH:C059514	7422	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of resveratrol on vascular_endothelial_growth_factor expression in osteosarcoma cells and cell proliferation .
25407017	0	resveratrol-salicylate	24,46	CYP1A1	69,75	resveratrol-salicylate	CYP1A1	null	1543	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Design and synthesis of resveratrol-salicylate hybrid derivatives as CYP1A1 inhibitors .
16574431	0	retinal	56,63	EphA4	23,28	retinal	EphA4	MESH:D012172	13838(Tax:10090)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Temporal regulation of EphA4 in astroglia during murine retinal and optic nerve development .
7854966	4	retinal	765,772	PKC	750,753	retinal	VIP	MESH:D012172	117064(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	By contrast , a PKC inhibitor , retinal -LRB- 2 x 10 -LRB- -5 -RRB- M -RRB- , decreased significantly these capacities .
18442442	0	retinal	114,121	extracellular_signal-regulated_kinase	41,78	retinal	extracellular signal-regulated kinase	MESH:D012172	5594	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|amod|END_ENTITY	Effects of unoprostone on phosphorylated extracellular_signal-regulated_kinase expression in endothelin-1-induced retinal and optic_nerve_damage .
20811044	12	retinal	1611,1618	iron	1619,1623	retinal	Hepc	MESH:D012172	84506(Tax:10090)	Chemical	Gene	regulation|amod|START_ENTITY regulation|compound|END_ENTITY	CONCLUSIONS : These findings indicate that Hepc is essential for retinal iron regulation .
15461454	0	retinal	27,34	rhodopsin	58,67	retinal	rhodopsin	MESH:D012172	509933(Tax:9913)	Chemical	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Deuterium NMR structure of retinal in the ground state of rhodopsin .
26098991	0	retinal	35,42	rhodopsin	80,89	retinal	rhodopsin	MESH:D012172	30295(Tax:7955)	Chemical	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	Comparative mutagenesis studies of retinal release in light-activated zebrafish rhodopsin using fluorescence spectroscopy .
24733397	0	retinaldehyde	4,17	DHRS3	40,45	retinaldehyde	DHRS3	MESH:D012172	20148(Tax:10090)	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	The retinaldehyde reductase activity of DHRS3 is reciprocally activated by retinol_dehydrogenase_10 to control retinoid homeostasis .
8819158	0	retinaldehyde	91,104	Xlcpl1	14,20	retinaldehyde	Xlcpl1	MESH:D012172	397884(Tax:8355)	Chemical	Gene	protein|compound|START_ENTITY protein|nsubj|END_ENTITY	The lipocalin Xlcpl1 expressed in the neural plate of Xenopus_laevis embryos is a secreted retinaldehyde binding protein .
3582580	0	retinaldehyde	18,31	cellular_retinaldehyde_binding_protein	58,96	retinaldehyde	cellular retinaldehyde binding protein	MESH:D012172	282038(Tax:9913)	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of 11-cis retinaldehyde to the partially purified cellular_retinaldehyde_binding_protein from bovine retinal pigment epithelium .
21566993	0	retinoic_Acid	18,31	rxr	82,85	retinoic Acid	rxr	MESH:D014212	6256	Chemical	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Expression of the retinoic_Acid nuclear receptors -LRB- rars -RRB- and retinoid_x-receptor -LRB- rxr -RRB- genes in estrogen-receptor positive and negative breast-cancer .
17825242	0	retinoic_acid	14,27	AJ18	67,71	retinoic acid	AJ18	MESH:D014212	78972(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|factor factor|appos|END_ENTITY	The effect of retinoic_acid on a zinc finger transcription factor , AJ18 , during differentiation of a rat clonal preosteoblastic cell line , ROB-C20 , into osteoblasts .
20375987	0	retinoic_acid	88,101	ALDH1A2	8,15	retinoic acid	ALDH1A2	MESH:D014212	8854	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|variant variant|compound|END_ENTITY	A human ALDH1A2 gene variant is associated with increased_newborn_kidney_size and serum retinoic_acid .
12453892	0	retinoic_acid	101,114	Activating_transcription_factor-2	0,33	retinoic acid	Activating transcription factor-2	MESH:D014212	1386	Chemical	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Activating_transcription_factor-2 mediates transcriptional regulation of gluconeogenic gene PEPCK by retinoic_acid .
9478048	0	retinoic_acid	48,61	Alcohol_dehydrogenase	0,21	retinoic acid	Alcohol dehydrogenase	MESH:D014212	58810(Tax:10090)	Chemical	Gene	synthesis|amod|START_ENTITY mediator|nmod|synthesis END_ENTITY|nmod|mediator	Alcohol_dehydrogenase as a critical mediator of retinoic_acid synthesis from vitamin_A in the mouse embryo .
7929425	0	retinoic_acid	35,48	Apolipoprotein_D	0,16	retinoic acid	Apolipoprotein D	MESH:D014212	347	Chemical	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Apolipoprotein_D gene induction by retinoic_acid is concomitant with growth_arrest and cell differentiation in human breast_cancer cells .
11181704	0	retinoic_acid	45,58	BCL-2	0,5	retinoic acid	BCL-2	MESH:D014212	12043(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|cooperates cooperates|compound|END_ENTITY	BCL-2 cooperates with promyelocytic_leukemia retinoic_acid receptor alpha chimeric protein -LRB- PMLRARalpha -RRB- to block neutrophil differentiation and initiate acute_leukemia .
9716607	0	retinoic_acid	67,80	BCL-2	19,24	retinoic acid	BCL-2	MESH:D014212	596	Chemical	Gene	cells|nmod|START_ENTITY Phosphorylation|nmod|cells Phosphorylation|nmod|END_ENTITY	Phosphorylation of BCL-2 after exposure of human leukemic cells to retinoic_acid .
20649843	0	retinoic_acid	98,111	BDNF	153,157	retinoic acid	BDNF	MESH:D014212	24225(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|up-regulation up-regulation|nmod|END_ENTITY	Midbrain dopaminergic neurons utilize nitric_oxide / cyclic_GMP signaling to recruit ERK that links retinoic_acid receptor stimulation to up-regulation of BDNF .
24592121	0	retinoic_acid	61,74	Bcl-2	37,42	retinoic acid	Bcl-2	MESH:D014212	596	Chemical	Gene	cells|amod|START_ENTITY Expression|nmod|cells Expression|nmod|END_ENTITY	Expression of URG4/URGCP , Cyclin_D1 , Bcl-2 , and Bax genes in retinoic_acid treated SH-SY5Y human neuroblastoma cells .
8790944	0	retinoic_acid	46,59	Bcl-2	23,28	retinoic acid	Bcl-2	MESH:D014212	596	Chemical	Gene	related|nmod|START_ENTITY related|nsubj|Induction Induction|nmod|mcl1/EAT mcl1/EAT|appos|END_ENTITY	Induction of mcl1/EAT , Bcl-2 related gene , by retinoic_acid or heat_shock in the human embryonal_carcinoma cells , NCR-G3 .
8593698	1	retinoic_acid	101,114	Brn-2	198,203	retinoic acid	Brn-2	MESH:D014212	18992(Tax:10090)	Chemical	Gene	Use|nmod|START_ENTITY Use|nmod|END_ENTITY	Use of retinoic_acid and antisense against the central nervous system-specific POU transcription factor Brn-2 .
15989786	0	retinoic_acid	15,28	C3_and_factor_B	32,47	retinoic acid	C3 and factor B	MESH:D014212	718	Chemical	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	-LSB- The effect of retinoic_acid on C3_and_factor_B secretion of human alveolar type II epithelial cells induced with cytokines -RSB- .
9886825	0	retinoic_acid	68,81	CBP	192,195	retinoic acid	CBP	MESH:D014212	1387	Chemical	Gene	protein|dep|START_ENTITY protein|appos|END_ENTITY	Expression of hepatocyte_growth_factor-like_protein is repressed by retinoic_acid and enhanced by cyclic_adenosine_3 ' ,5 ' - monophosphate response element-binding protein -LRB- CREB -RRB- - binding protein -LRB- CBP -RRB- .
17977671	0	retinoic_acid	82,95	CD-RAP	115,121	retinoic acid	CD-RAP	MESH:D014212	8190	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Molecular characterization and chromosomal assignment of equine cartilage derived retinoic_acid sensitive protein -LRB- CD-RAP -RRB- / melanoma_inhibitory_activity -LRB- MIA -RRB- .
16982809	0	retinoic_acid	49,62	CD1d	19,23	retinoic acid	CD1d	MESH:D014212	912	Chemical	Gene	synthesis|amod|START_ENTITY turning|nmod|synthesis controls|advcl|turning controls|dobj|expression expression|amod|END_ENTITY	PPARgamma controls CD1d expression by turning on retinoic_acid synthesis in developing human dendritic cells .
19651460	0	retinoic_acid	48,61	CD1d	19,23	retinoic acid	CD1d	MESH:D014212	912	Chemical	Gene	conduritol-B-epoxide|dep|START_ENTITY responsiveness|amod|conduritol-B-epoxide induced|nmod|responsiveness induced|csubj|Uncoupling Uncoupling|nmod|upregulation upregulation|amod|END_ENTITY	Uncoupling between CD1d upregulation induced by retinoic_acid and conduritol-B-epoxide and iNKT cell responsiveness .
9624127	0	retinoic_acid	53,66	CD38	29,33	retinoic acid	CD38	MESH:D014212	952	Chemical	Gene	mechanism|nmod|START_ENTITY mechanism|nmod|expression expression|compound|END_ENTITY	Molecular mechanism of human CD38 gene expression by retinoic_acid .
19233184	0	retinoic_acid	40,53	CD8	24,27	retinoic acid	CD8	MESH:D014212	925	Chemical	Gene	START_ENTITY|nsubjpass|receptors receptors|nmod|cells cells|compound|END_ENTITY	Gut homing receptors on CD8 T cells are retinoic_acid dependent and not maintained by liver dendritic_or_stellate cells .
10629053	0	retinoic_acid	118,131	COUP-TF	16,23	retinoic acid	COUP-TF	MESH:D014212	7025	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Orphan receptor COUP-TF is required for induction of retinoic_acid receptor beta , growth inhibition , and apoptosis by retinoic_acid in cancer cells .
10023853	0	retinoic_acid	44,57	CR1	92,95	retinoic acid	CR1	MESH:D014212	1378	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Complement_receptor_type_1 gene regulation : retinoic_acid and cytosine_arabinoside increase CR1 expression .
1648546	0	retinoic_acid	29,42	CRABP	60,65	retinoic acid	CRABP	MESH:D014212	1381	Chemical	Gene	binding|amod|START_ENTITY gene|amod|binding gene|appos|END_ENTITY	Localization of the cellular retinoic_acid binding protein -LRB- CRABP -RRB- gene relative to the acute_promyelocytic_leukemia-associated breakpoint on human chromosome 15 .
1653151	0	retinoic_acid	25,38	CRABP	83,88	retinoic acid	CRABP	MESH:D014212	1381	Chemical	Gene	distribution|nmod|START_ENTITY distribution|appos|END_ENTITY	Temporal distribution of retinoic_acid and cellular retinoic_acid-binding protein -LRB- CRABP -RRB- in the fetal hamster .
1653241	0	retinoic_acid	23,36	CRABP	54,59	retinoic acid	CRABP	MESH:D014212	1381	Chemical	Gene	START_ENTITY|dobj|protein protein|appos|END_ENTITY	Expression of cellular retinoic_acid binding protein -LRB- CRABP -RRB- in Escherichia_coli .
3035450	0	retinoic_acid	9,22	CRABP	40,45	retinoic acid	CRABP	MESH:D014212	1381	Chemical	Gene	START_ENTITY|dobj|protein protein|appos|END_ENTITY	Cellular retinoic_acid binding protein -LRB- CRABP -RRB- in retinoblastoma .
8381481	0	retinoic_acid	73,86	CRBP	55,59	retinoic acid	CRBP	MESH:D014212	5947	Chemical	Gene	roles|nmod|START_ENTITY roles|nmod|END_ENTITY	Biosynthesis and metabolism of retinoic_acid : roles of CRBP and CRABP in retinoic_acid : roles of CRBP and CRABP in retinoic_acid homeostasis .
17646388	0	retinoic_acid	63,76	CREB	39,43	retinoic acid	CREB	MESH:D014212	1385	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|expression expression|nmod|END_ENTITY	Regulation of mucin gene expression by CREB via a nonclassical retinoic_acid signaling pathway .
15725648	0	retinoic_acid	22,35	CREM	86,90	retinoic acid	CREM	MESH:D014212	25620(Tax:10116)	Chemical	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	The administration of retinoic_acid down-regulates cAMP-responsive_element_modulator -LRB- CREM -RRB- mRNA in vitamin_A-deficient testes .
10354487	0	retinoic_acid	14,27	CYP26	43,48	retinoic acid	CYP26	MESH:D014212	13082(Tax:10090)	Chemical	Gene	4-hydroxylase|amod|START_ENTITY Expression|nmod|4-hydroxylase Expression|appos|END_ENTITY	Expression of retinoic_acid 4-hydroxylase -LRB- CYP26 -RRB- during mouse and Xenopus_laevis embryogenesis .
11157777	0	retinoic_acid	100,113	CYP26	38,43	retinoic acid	CYP26	MESH:D014212	13082(Tax:10090)	Chemical	Gene	distribution|nmod|START_ENTITY establishing|dobj|distribution essential|advcl|establishing essential|nsubj|END_ENTITY	The retinoic_acid-inactivating enzyme CYP26 is essential for establishing an uneven distribution of retinoic_acid along the anterio-posterior axis within the mouse embryo .
11471143	0	retinoic_acid	94,107	CYP26	35,40	retinoic acid	CYP26	MESH:D014212	1592	Chemical	Gene	bud|xcomp|START_ENTITY bud|nsubj|expression expression|nmod|END_ENTITY	Differential expression of chicken CYP26 in anterior versus posterior limb bud in response to retinoic_acid .
17486130	0	retinoic_acid	23,36	CYP26	82,87	retinoic acid	CYP26	MESH:D014212	13082(Tax:10090)	Chemical	Gene	metabolism|amod|START_ENTITY targeting|nmod|metabolism targeting|dep|role role|nmod|R116010 R116010|compound|END_ENTITY	Molecular targeting of retinoic_acid metabolism in neuroblastoma : the role of the CYP26 inhibitor R116010 in vitro and in vivo .
18608743	0	retinoic_acid	101,114	CYP26	135,140	retinoic acid	CYP26	MESH:D014212	1592	Chemical	Gene	metabolizing|amod|START_ENTITY inhibitors|nmod|metabolizing END_ENTITY|dep|inhibitors	Design and synthesis of substituted imidazole and triazole_N-phenylbenzo -LSB- d -RSB- oxazolamine inhibitors of retinoic_acid metabolizing enzyme CYP26 .
19519282	0	retinoic_acid	29,42	CYP26	12,17	retinoic acid	CYP26	MESH:D014212	1592	Chemical	Gene	clearance|amod|START_ENTITY role|nmod|clearance role|nmod|enzymes enzymes|nummod|END_ENTITY	The role of CYP26 enzymes in retinoic_acid clearance .
20842651	0	retinoic_acid	50,63	CYP26	12,17	retinoic acid	CYP26	MESH:D014212	13082(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|enzymes enzymes|nummod|END_ENTITY	The role of CYP26 enzymes in defining appropriate retinoic_acid exposure during embryogenesis .
21428449	0	retinoic_acid	29,42	CYP26	58,63	retinoic acid	CYP26	MESH:D014212	1592	Chemical	Gene	4-hydroxylase|amod|START_ENTITY 4-hydroxylase|appos|END_ENTITY	Small molecule inhibitors of retinoic_acid 4-hydroxylase -LRB- CYP26 -RRB- : synthesis and biological evaluation of imidazole_methyl 3 - -LRB- 4 - -LRB- aryl-2-ylamino -RRB- phenyl -RRB- propanoates .
21838328	0	retinoic_acid	171,184	CYP26	200,205	retinoic acid	CYP26	MESH:D014212	1592	Chemical	Gene	4-hydroxylase|amod|START_ENTITY 4-hydroxylase|appos|END_ENTITY	Synthesis and biological evaluation of 3 - -LRB- 1H-imidazol - _ and_triazol-1-yl -RRB- -2,2 - dimethyl-3 - -LSB- 4 - -LRB- naphthalen-2-ylamino -RRB- phenyl -RSB- propyl derivatives as small molecule inhibitors of retinoic_acid 4-hydroxylase -LRB- CYP26 -RRB- .
22727372	0	retinoic_acid	6,19	CYP26	35,40	retinoic acid	CYP26	MESH:D014212	1592	Chemical	Gene	START_ENTITY|dobj|inhibitors inhibitors|appos|END_ENTITY	Novel retinoic_acid 4-hydroxylase -LRB- CYP26 -RRB- inhibitors based on a 3 - -LRB- 1H-imidazol - _ and_triazol-1-yl -RRB- -2,2 - dimethyl-3 - -LRB- 4 - -LRB- phenylamino -RRB- phenyl -RRB- propyl scaffold .
9442090	0	retinoic_acid	115,128	CYP26	15,20	retinoic acid	CYP26	MESH:D014212	13082(Tax:10090)	Chemical	Gene	gamma|amod|START_ENTITY regulated|nmod|gamma regulated|nsubjpass|expression expression|appos|END_ENTITY	Mouse P450RAI -LRB- CYP26 -RRB- expression and retinoic_acid-inducible retinoic_acid metabolism in F9 cells are regulated by retinoic_acid receptor gamma and retinoid_X receptor alpha .
9564181	0	retinoic_acid	99,112	CYP26	68,73	retinoic acid	CYP26	MESH:D014212	1592	Chemical	Gene	specificity|nmod|START_ENTITY family|nmod|specificity family|appos|END_ENTITY	The cloning and characterization of a novel cytochrome P450 family , CYP26 , with specificity toward retinoic_acid .
9716180	0	retinoic_acid	6,19	CYP26	40,45	retinoic acid	CYP26	MESH:D014212	1592	Chemical	Gene	_|amod|START_ENTITY _|amod|4-hydroxylase 4-hydroxylase|dep|END_ENTITY	Human retinoic_acid _ -LRB- RA -RRB- _ 4-hydroxylase -LRB- CYP26 -RRB- is highly specific for all-trans-RA and can be induced through RA receptors in human breast and colon_carcinoma cells .
12971996	0	retinoic_acid	102,115	CYP26B1	52,59	retinoic acid	CYP26B1	MESH:D014212	428809(Tax:9031)	Chemical	Gene	enzyme|nmod|START_ENTITY enzyme|dobj|END_ENTITY	Expression of the retinoic_acid catabolising enzyme CYP26B1 in the chick embryo and its regulation by retinoic_acid .
12971996	0	retinoic_acid	18,31	CYP26B1	52,59	retinoic acid	CYP26B1	MESH:D014212	428809(Tax:9031)	Chemical	Gene	catabolising|amod|START_ENTITY Expression|nmod|catabolising enzyme|nsubj|Expression enzyme|dobj|END_ENTITY	Expression of the retinoic_acid catabolising enzyme CYP26B1 in the chick embryo and its regulation by retinoic_acid .
17616924	0	retinoic_acid	4,17	CYP26B1	37,44	retinoic acid	CYP26B1	MESH:D014212	324188(Tax:7955)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The retinoic_acid metabolising gene , CYP26B1 , patterns the cartilaginous_cranial_neural_crest in zebrafish .
22415012	0	retinoic_acid	32,45	CYP26B1	2,9	retinoic acid	CYP26B1	MESH:D014212	56603	Chemical	Gene	catabolism|amod|START_ENTITY enhances|dobj|catabolism enhances|nsubj|polymorphism polymorphism|compound|END_ENTITY	A CYP26B1 polymorphism enhances retinoic_acid catabolism and may aggravate atherosclerosis .
22985482	0	retinoic_acid	35,48	CYP26B1	70,77	retinoic acid	CYP26B1	MESH:D014212	56603	Chemical	Gene	START_ENTITY|xcomp|metabolizing metabolizing|xcomp|variant variant|nsubj|END_ENTITY	Homology models of human all-trans retinoic_acid metabolizing enzymes CYP26B1 and CYP26B1 spliced variant .
23977348	0	retinoic_acid	20,33	CYP26B1	54,61	retinoic acid	CYP26B1	MESH:D014212	56603	Chemical	Gene	metabolizing|amod|START_ENTITY Polymorphism|nmod|metabolizing enzyme|nsubj|Polymorphism enzyme|dobj|END_ENTITY	Polymorphism in the retinoic_acid metabolizing enzyme CYP26B1 and the development of Crohn 's _ Disease .
26374207	0	retinoic_acid	18,31	CYP26B1	49,56	retinoic acid	CYP26B1	MESH:D014212	56603	Chemical	Gene	catabolic|amod|START_ENTITY Expression|nmod|catabolic enzyme|nsubj|Expression enzyme|dobj|END_ENTITY	Expression of the retinoic_acid catabolic enzyme CYP26B1 in the human brain to maintain signaling homeostasis .
20147703	0	retinoic_acid	61,74	CYP2C22	31,38	retinoic acid	CYP2C22	MESH:D014212	171518(Tax:10116)	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Liver-specific cytochrome P450 CYP2C22 is a direct target of retinoic_acid and a retinoic_acid-metabolizing enzyme in rat liver .
24490503	0	retinoic_acid	12,25	Cx43	47,51	retinoic acid	Cx43	MESH:D014212	14609(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of retinoic_acid on the expression of Cx43 and its gap juncion intercellular communication function in testicular_cancer cell -RSB- .
17164423	0	retinoic_acid	27,40	Cyp26	0,5	retinoic acid	Cyp26	MESH:D014212	1592	Chemical	Gene	pattern|amod|START_ENTITY necessary|nsubj|pattern generate|xcomp|necessary generate|nsubj|enzymes enzymes|amod|END_ENTITY	Cyp26 enzymes generate the retinoic_acid response pattern necessary for hindbrain development .
22366455	0	retinoic_acid	10,23	Cyp26b1	51,58	retinoic acid	Cyp26b1	MESH:D014212	56603	Chemical	Gene	levels|amod|START_ENTITY levels|nmod|ablation ablation|nmod|END_ENTITY	Increased retinoic_acid levels through ablation of Cyp26b1 determine the processes of embryonic skin barrier formation and peridermal development .
18485106	0	retinoic_acid	65,78	DARPP-32	92,100	retinoic acid	DARPP-32	MESH:D014212	84152	Chemical	Gene	START_ENTITY|dobj|induction induction|nmod|END_ENTITY	Phosphatidylinositide 3-kinase and protein kinase C zeta mediate retinoic_acid induction of DARPP-32 in medium size spiny neurons in vitro .
17509854	0	retinoic_acid	10,23	ERK5	55,59	retinoic acid	ERK5	MESH:D014212	114509(Tax:10116)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	All-trans retinoic_acid regulates c-jun expression via ERK5 in cardiac myoblasts .
9302644	0	retinoic_acid	38,51	Elastin	0,7	retinoic acid	Elastin	MESH:D014212	396441(Tax:9031)	Chemical	Gene	up-regulated|nmod|START_ENTITY up-regulated|nsubjpass|expression expression|compound|END_ENTITY	Elastin expression is up-regulated by retinoic_acid but not by retinol in chick embryonic skin fibroblasts .
17361080	0	retinoic_acid	60,73	Epidermal_growth_factor	0,23	retinoic acid	Epidermal growth factor	MESH:D014212	1950	Chemical	Gene	_|amod|START_ENTITY _|compound|END_ENTITY	Epidermal_growth_factor - , transforming growth factor-beta - , retinoic_acid - and 1,25-dihydroxyvitamin _ D3-regulated expression of the novel protein PTPIP51 in keratinocytes .
8590777	0	retinoic_acid	69,82	Epidermal_growth_factor	0,23	retinoic acid	Epidermal growth factor	MESH:D014212	1950	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|END_ENTITY	Epidermal_growth_factor in acute_promyelocytic_leukemia treated with retinoic_acid .
11856352	0	retinoic_acid	33,46	FasL	14,18	retinoic acid	FasL	MESH:D014212	356	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Repression of FasL expression by retinoic_acid involves a novel mechanism of inhibition of transactivation function of the nuclear factors of activated T-cells .
10951230	0	retinoic_acid	132,145	Fas_ligand	37,47	retinoic acid	Fas ligand	MESH:D014212	356	Chemical	Gene	upregulation|nmod|START_ENTITY upregulation|nmod|expression expression|compound|END_ENTITY	Selective upregulation of fibroblast Fas_ligand expression , and prolongation of Fas/Fas _ ligand-mediated skin allograft survival , by retinoic_acid : the skin as a retinoide-inducible immune privilege site .
7536793	0	retinoic_acid	117,130	Fas_ligand	92,102	retinoic acid	Fas ligand	MESH:D014212	356	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|expression expression|compound|END_ENTITY	Fas and activation-induced Fas_ligand mediate apoptosis of T cell hybridomas : inhibition of Fas_ligand expression by retinoic_acid and glucocorticoids .
17620362	0	retinoic_acid	99,112	Foxp3	77,82	retinoic acid	Foxp3	MESH:D014212	50943	Chemical	Gene	cells|nmod|START_ENTITY cells|amod|END_ENTITY	Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic_acid .
21365646	0	retinoic_acid	45,58	GADD153	92,99	retinoic acid	GADD153	MESH:D014212	1649	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Impact of intracellular alpha_fetoprotein on retinoic_acid receptors-mediated expression of GADD153 in human hepatoma cell lines .
18052213	0	retinoic_acid	75,88	Galactomutarotase	0,17	retinoic acid	Galactomutarotase	MESH:D014212	130589	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Galactomutarotase and other galactose-related genes are rapidly induced by retinoic_acid in human myeloid cells .
9305907	0	retinoic_acid	100,113	Galpha12	0,8	retinoic acid	Galpha12	MESH:D014212	14673(Tax:10090)	Chemical	Gene	mediate|advcl|START_ENTITY mediate|nsubj|END_ENTITY	Galpha12 and Galpha13 mediate differentiation of P19 mouse embryonal_carcinoma cells in response to retinoic_acid .
9305907	7	retinoic_acid	1255,1268	Galpha12	1177,1185	retinoic acid	Galpha12	MESH:D014212	14673(Tax:10090)	Chemical	Gene	essential|nmod|START_ENTITY essential|nsubj|END_ENTITY	Thus , both Galpha12 and Galpha13 are essential to stimulation of cell differentiation by retinoic_acid .
24973045	0	retinoic_acid	84,97	Gck	119,122	retinoic acid	Gck	MESH:D014212	24385(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	A RARE of hepatic Gck promoter interacts with RARa , HNF4a and COUP-TFII that affect retinoic_acid - and insulin-induced Gck expression .
24973045	0	retinoic_acid	84,97	Gck	18,21	retinoic acid	Gck	MESH:D014212	24385(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY affect|dobj|expression interacts|acl:relcl|affect interacts|compound|END_ENTITY	A RARE of hepatic Gck promoter interacts with RARa , HNF4a and COUP-TFII that affect retinoic_acid - and insulin-induced Gck expression .
8882165	0	retinoic_acid	97,110	Growth_hormone	0,14	retinoic acid	Growth hormone	MESH:D014212	14599(Tax:10090)	Chemical	Gene	differentiation|compound|START_ENTITY modulation|nmod|differentiation binds|dep|modulation binds|amod|END_ENTITY	Growth_hormone binds to a single high affinity receptor site on mouse osteoblasts : modulation by retinoic_acid and cell differentiation .
10413451	0	retinoic_acid	59,72	HERG	14,18	retinoic acid	HERG	MESH:D014212	3757	Chemical	Gene	treatment|amod|START_ENTITY END_ENTITY|nmod|treatment	Modulation of HERG current and herg gene expression during retinoic_acid treatment of human neuroblastoma cells : potentiating effects of BDNF .
8612233	0	retinoic_acid	53,66	HMG-CoA_reductase	0,17	retinoic acid	HMG-CoA reductase	MESH:D014212	3156	Chemical	Gene	effects|nmod|START_ENTITY mediates|dobj|effects mediates|nsubj|END_ENTITY	HMG-CoA_reductase mediates the biological effects of retinoic_acid on human neuroblastoma cells : lovastatin specifically targets P-glycoprotein-expressing cells .
19477923	0	retinoic_acid	35,48	HoxB	13,17	retinoic acid	HoxB	MESH:D014212	3210	Chemical	Gene	transcription|nmod|START_ENTITY transcription|compound|END_ENTITY	Induction of HoxB transcription by retinoic_acid requires actin polymerization .
9053316	0	retinoic_acid	45,58	Hoxa-1	35,41	retinoic acid	Hoxa-1	MESH:D014212	15394(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|analysis analysis|nmod|END_ENTITY	In vivo functional analysis of the Hoxa-1 3 ' retinoic_acid response element -LRB- 3 ` RARE -RRB- .
11891985	0	retinoic_acid	25,38	Hoxb1	78,83	retinoic acid	Hoxb1	MESH:D014212	15407(Tax:10090)	Chemical	Gene	elements|amod|START_ENTITY Analysis|nmod|elements Analysis|nmod|END_ENTITY	Analysis of two distinct retinoic_acid response elements in the homeobox gene Hoxb1 in transgenic_mice .
1370436	0	retinoic_acid	76,89	ICAM-1	44,50	retinoic acid	ICAM-1	MESH:D014212	3383	Chemical	Gene	stimulated|nmod|START_ENTITY stimulated|nsubj|effect effect|nmod|agents agents|nmod|expression expression|compound|END_ENTITY	Biphasic effect of cAMP-elevating agents on ICAM-1 expression stimulated by retinoic_acid and interferon_gamma .
1680399	0	retinoic_acid	14,27	ICAM-1	31,37	retinoic acid	ICAM-1	MESH:D014212	3383	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation by retinoic_acid of ICAM-1 expression on human tumor cell lines .
7737364	0	retinoic_acid	91,104	ICAM-1	80,86	retinoic acid	ICAM-1	MESH:D014212	3383	Chemical	Gene	gene|nmod|START_ENTITY gene|dep|END_ENTITY	Transcriptional modulation of the human intercellular adhesion molecule gene I -LRB- ICAM-1 -RRB- by retinoic_acid in melanoma cells .
7913411	5	retinoic_acid	919,932	ICAM-1	778,784	retinoic acid	ICAM-1	MESH:D014212	3383	Chemical	Gene	use|nsubj|START_ENTITY stimulate|advcl|use use|xcomp|stimulate suggesting|ccomp|use stimulated|advcl|suggesting stimulated|dobj|expression expression|compound|END_ENTITY	Both Ca -LRB- 2 + -RRB- - mobilizing agents stimulated ICAM-1 expression additively to IFN-gamma but not to retinoic_acid , suggesting that IFN-gamma does not use Ca2 + to stimulate ICAM-1 , whereas retinoic_acid might use it in part .
12421932	0	retinoic_acid	84,97	IL-2	116,120	retinoic acid	IL-2	MESH:D014212	3558	Chemical	Gene	secretion|amod|START_ENTITY secretion|compound|END_ENTITY	Retinoic_acid stimulates the cell cycle machinery in normal T cells : involvement of retinoic_acid receptor-mediated IL-2 secretion .
14978018	0	retinoic_acid	57,70	IL-2	88,92	retinoic acid	IL-2	MESH:D014212	3558	Chemical	Gene	START_ENTITY|nmod|induction induction|nmod|END_ENTITY	Survival of activated human T lymphocytes is promoted by retinoic_acid via induction of IL-2 .
11306982	0	retinoic_acid	88,101	IL-5_receptor	14,27	retinoic acid	IL-5 receptor	MESH:D014212	3568	Chemical	Gene	role|nmod|START_ENTITY Regulation|dep|role Regulation|nmod|END_ENTITY	Regulation of IL-5_receptor on eosinophil progenitors in allergic_inflammation : role of retinoic_acid .
8603400	0	retinoic_acid	54,67	Insulin-like_growth_factor_binding_protein_3	0,44	retinoic acid	Insulin-like growth factor binding protein 3	MESH:D014212	3486	Chemical	Gene	inhibition|amod|START_ENTITY mediates|dobj|inhibition mediates|nsubj|END_ENTITY	Insulin-like_growth_factor_binding_protein_3 mediates retinoic_acid - and transforming_growth_factor_beta2-induced growth inhibition in human breast_cancer cells .
11668484	0	retinoic_acid	33,46	Interferon-gamma	0,16	retinoic acid	Interferon-gamma	MESH:D014212	3458	Chemical	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Interferon-gamma cooperates with retinoic_acid and phorbol_ester to induce differentiation and growth inhibition of human neuroblastoma cells .
1281867	0	retinoic_acid	22,35	K14	97,100	retinoic acid	K14	MESH:D014212	3861	Chemical	Gene	element|amod|START_ENTITY Identification|nmod|element Identification|nmod|gene gene|compound|END_ENTITY	Identification of the retinoic_acid and thyroid_hormone receptor-responsive element in the human K14 keratin gene .
17670908	0	retinoic_acid	70,83	LGL1	0,4	retinoic acid	LGL1	MESH:D014212	78892(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	LGL1 , a novel branching morphogen in developing kidney , is induced by retinoic_acid .
9295165	0	retinoic_acid	61,74	LTC4_synthase	35,48	retinoic acid	LTC4 synthase	MESH:D014212	114097(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|activity activity|amod|END_ENTITY	Post-transcriptional regulation of LTC4_synthase activity by retinoic_acid in rat_basophilic_leukemia cells .
20057335	0	retinoic_acid	31,44	Lgl1	14,18	retinoic acid	Lgl1	MESH:D014212	171547(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Modulation Modulation|nmod|END_ENTITY	Modulation of Lgl1 by steroid , retinoic_acid , and vitamin_D models complex transcriptional regulation during alveolarization .
1610391	0	retinoic_acid	101,114	Lipoprotein_lipase	0,18	retinoic acid	Lipoprotein lipase	MESH:D014212	4023	Chemical	Gene	down-regulated|advcl|START_ENTITY down-regulated|nsubj|expression expression|amod|END_ENTITY	Lipoprotein_lipase enzyme expression in 3T3-L1 adipocytes is posttranscriptionally down-regulated by retinoic_acid .
10807916	0	retinoic_acid	46,59	MEKK4	0,5	retinoic acid	MEKK4	MESH:D014212	26407(Tax:10090)	Chemical	Gene	mediates|xcomp|START_ENTITY mediates|nsubj|END_ENTITY	MEKK4 mediates differentiation in response to retinoic_acid via activation of c-Jun N-terminal kinase in rat embryonal_carcinoma P19 cells .
17977671	0	retinoic_acid	82,95	MIA	153,156	retinoic acid	MIA	MESH:D014212	100064799(Tax:9796)	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Molecular characterization and chromosomal assignment of equine cartilage derived retinoic_acid sensitive protein -LRB- CD-RAP -RRB- / melanoma_inhibitory_activity -LRB- MIA -RRB- .
12569559	0	retinoic_acid	96,109	MICA	23,27	retinoic acid	MICA	MESH:D014212	100507436	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression and role of MICA and MICB_in_human_hepatocellular_carcinomas and their regulation by retinoic_acid .
10646501	0	retinoic_acid	67,80	MMP-9	38,43	retinoic acid	MMP-9	MESH:D014212	4318	Chemical	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	Induction of matrix metalloproteinase MMP-9 -LRB- 92-kDa gelatinase -RRB- by retinoic_acid in human neuroblastoma SKNBE cells : relevance to neuronal differentiation .
16249480	0	retinoic_acid	10,23	MUC16	140,145	retinoic acid	MUC16	MESH:D014212	94025	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|induction induction|nmod|END_ENTITY	Effect of retinoic_acid on gene expression in human conjunctival epithelium : secretory phospholipase A2 mediates retinoic_acid induction of MUC16 .
16249480	0	retinoic_acid	113,126	MUC16	140,145	retinoic acid	MUC16	MESH:D014212	94025	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Effect of retinoic_acid on gene expression in human conjunctival epithelium : secretory phospholipase A2 mediates retinoic_acid induction of MUC16 .
17091192	0	retinoic_acid	51,64	Mespo	33,38	retinoic acid	Mespo	MESH:D014212	100216477(Tax:8355)	Chemical	Gene	expression|amod|START_ENTITY promoter|nmod|expression promoter|compound|END_ENTITY	Cloning and analyzing of Xenopus Mespo promoter in retinoic_acid regulated Mespo expression .
17091192	0	retinoic_acid	51,64	Mespo	75,80	retinoic acid	Mespo	MESH:D014212	100216477(Tax:8355)	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Cloning and analyzing of Xenopus Mespo promoter in retinoic_acid regulated Mespo expression .
15591039	0	retinoic_acid	87,100	Mucin	0,5	retinoic acid	Mucin	MESH:D014212	100508689	Chemical	Gene	cytokines|amod|START_ENTITY N-acetylglucosaminyltransferase|nmod|cytokines upregulation|nmod|N-acetylglucosaminyltransferase biosynthesis|dep|upregulation biosynthesis|compound|END_ENTITY	Mucin biosynthesis : upregulation of core_2_beta_1 ,6 _ N-acetylglucosaminyltransferase by retinoic_acid and Th2 cytokines in a human airway epithelial cell line .
1565467	0	retinoic_acid	57,70	N-myc	84,89	retinoic acid	N-myc	MESH:D014212	4613	Chemical	Gene	START_ENTITY|nmod|promoter promoter|compound|END_ENTITY	Cell type-specific expression and negative regulation by retinoic_acid of the human N-myc promoter in neuroblastoma cells .
10222420	0	retinoic_acid	103,116	NCAM	161,165	retinoic acid	NCAM	MESH:D014212	4684	Chemical	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Paucity of retinoic_acid_receptor_alpha -LRB- RAR_alpha -RRB- nuclear immunostaining in gliomas and inability of retinoic_acid to influence neural_cell_adhesion_molecule -LRB- NCAM -RRB- expression .
20159962	0	retinoic_acid	20,33	Nanos2	46,52	retinoic acid	Nanos2	MESH:D014212	378430(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Opposing effects of retinoic_acid and FGF9 on Nanos2 expression and meiotic entry of mouse germ cells .
1467987	0	retinoic_acid	110,123	P19	78,81	retinoic acid	P19	MESH:D014212	83430(Tax:10090)	Chemical	Gene	induction|nmod|START_ENTITY END_ENTITY|nmod|induction	Chronological expression of microtubule-associated proteins -LRB- MAPs -RRB- in EC cell P19 after neuronal induction by retinoic_acid .
1936556	0	retinoic_acid	69,82	P19	86,89	retinoic acid	P19	MESH:D014212	83430(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	The transcription factor , Egr-1 , is rapidly modulated in response to retinoic_acid in P19 embryonal_carcinoma cells .
20941745	0	retinoic_acid	93,106	PAX9	62,66	retinoic acid	PAX9	MESH:D014212	5083	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Transcriptional activity analysis of promoter region of human PAX9 gene under dexamethasone , retinoic_acid , and ergocalciferol treatment in MCF-7 and MDPC23 .
10486248	0	retinoic_acid	83,96	PKC_alpha	43,52	retinoic acid	PKC alpha	MESH:D014212	18750(Tax:10090)	Chemical	Gene	element|amod|START_ENTITY identification|nmod|element Cloning|dep|identification Cloning|nmod|promoter promoter|compound|END_ENTITY	Cloning and characterization of the murine PKC_alpha promoter : identification of a retinoic_acid response element .
23856557	0	retinoic_acid	21,34	Prdm12	0,6	retinoic acid	Prdm12	MESH:D014212	381359(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Prdm12 is induced by retinoic_acid and exhibits anti-proliferative properties through the cell cycle modulation of P19 embryonic_carcinoma cells .
11562472	0	retinoic_acid	22,35	RAE-1	60,65	retinoic acid	RAE-1	MESH:D014212	8480	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Ectopic expression of retinoic_acid early inducible-1 gene -LRB- RAE-1 -RRB- permits natural killer cell-mediated rejection of a MHC class I-bearing tumor in vivo .
1655630	0	retinoic_acid	26,39	RAR	50,53	retinoic acid	RAR	MESH:D014212	19401(Tax:10090)	Chemical	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Chromosomal assignment of retinoic_acid receptor -LRB- RAR -RRB- genes in the human , mouse , and rat genomes .
17325034	0	retinoic_acid	13,26	RAR	37,40	retinoic acid	RAR	MESH:D014212	19401(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	CSK controls retinoic_acid receptor -LRB- RAR -RRB- signaling : a RAR-c-SRC signaling axis is required for neuritogenic differentiation .
17641689	1	retinoic_acid	135,148	RAR	184,187	retinoic acid	RXR	MESH:D014212	6256	Chemical	Gene	START_ENTITY|amod|bound bound|dep|retinoic_acid_receptor retinoic_acid_receptor|appos|END_ENTITY	We isolated MED25 , which associates with retinoic_acid -LRB- RA -RRB- - bound retinoic_acid_receptor -LRB- RAR -RRB- through the C-terminal nuclear hormone receptor -LRB- NR -RRB- box/LxxLL motif , and increases RAR/RXR-mediated transcription .
1850696	0	retinoic_acid	9,22	RAR	75,78	retinoic acid	RAR	MESH:D014212	5914	Chemical	Gene	induction|amod|START_ENTITY involves|nsubj|induction involves|xcomp|binding binding|nsubj|END_ENTITY	The late retinoic_acid induction of laminin_B1 gene transcription involves RAR binding to the responsive element .
20736163	0	retinoic_acid	134,147	RAR	112,115	retinoic acid	RAR	MESH:D014212	5914	Chemical	Gene	absence|nmod|START_ENTITY adaptor|nmod|absence adaptor|nmod|END_ENTITY	A novel cytoplasmic adaptor for retinoic_acid_receptor -LRB- RAR -RRB- and thyroid receptor functions as a Derepressor of RAR in the absence of retinoic_acid .
20736163	0	retinoic_acid	134,147	RAR	56,59	retinoic acid	RAR	MESH:D014212	5914	Chemical	Gene	absence|nmod|START_ENTITY adaptor|nmod|absence adaptor|nmod|retinoic_acid_receptor retinoic_acid_receptor|appos|END_ENTITY	A novel cytoplasmic adaptor for retinoic_acid_receptor -LRB- RAR -RRB- and thyroid receptor functions as a Derepressor of RAR in the absence of retinoic_acid .
23321499	0	retinoic_acid	38,51	RAR	77,80	retinoic acid	RAR	MESH:D014212	10966	Chemical	Gene	resistance|amod|START_ENTITY confer|dobj|resistance confer|advcl|repressing repressing|dobj|activity activity|compound|END_ENTITY	Zyxin cooperates with PTOV1 to confer retinoic_acid resistance by repressing RAR activity .
24875094	0	retinoic_acid	8,21	RAR	32,35	retinoic acid	RAR	MESH:D014212	5914	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Role of retinoic_acid receptor -LRB- RAR -RRB- signaling in post-natal male germ cell differentiation .
3002533	0	retinoic_acid	17,30	RAR	41,44	retinoic acid	RAR	MESH:D014212	5914	Chemical	Gene	status|amod|START_ENTITY status|appos|END_ENTITY	The influence of retinoic_acid receptor -LRB- RAR -RRB- status of bladder_tumours on the course of the disease .
7852380	0	retinoic_acid	11,24	RAR	35,38	retinoic acid	RAR	MESH:D014212	5914	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Endogenous retinoic_acid receptor -LRB- RAR -RRB- - retinoid_X_receptor -LRB- RXR -RRB- heterodimers are the major functional forms regulating retinoid-responsive elements in adult human keratinocytes .
8734497	0	retinoic_acid	21,34	RAR	45,48	retinoic acid	RAR	MESH:D014212	19401(Tax:10090)	Chemical	Gene	beta|amod|START_ENTITY beta|appos|END_ENTITY	Compound mutants for retinoic_acid receptor -LRB- RAR -RRB- beta and RAR_alpha_1 reveal developmental functions for multiple RAR_beta isoforms .
9345016	0	retinoic_acid	50,63	RAR	113,116	retinoic acid	RAR	MESH:D014212	5914	Chemical	Gene	differentiation|nmod|START_ENTITY apoptosis|nmod|differentiation Induction|nmod|apoptosis requires|nsubj|Induction requires|dobj|activation activation|nmod|END_ENTITY	Induction of apoptosis without differentiation by retinoic_acid in PLB-985 cells requires the activation of both RAR and RXR .
1380150	4	retinoic_acid	608,621	RAR-alpha	632,641	retinoic acid	RAR-alpha	MESH:D014212	24705(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	To address the role of the retinoic_acid receptor -LRB- RAR-alpha -RRB- in mediating the transformation-inhibitory effect of retinoic_acid , we have overexpressed either RAR-alpha or cellular_retinoic_acid-binding_protein_I -LRB- CRABP -RRB- cDNAs in F111 cells .
1380150	4	retinoic_acid	696,709	RAR-alpha	632,641	retinoic acid	RAR-alpha	MESH:D014212	24705(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY mediating|dobj|effect address|advcl|mediating address|dobj|role role|nmod|receptor receptor|appos|END_ENTITY	To address the role of the retinoic_acid receptor -LRB- RAR-alpha -RRB- in mediating the transformation-inhibitory effect of retinoic_acid , we have overexpressed either RAR-alpha or cellular_retinoic_acid-binding_protein_I -LRB- CRABP -RRB- cDNAs in F111 cells .
1970118	0	retinoic_acid	116,129	RAR-alpha	140,149	retinoic acid	RAR-alpha	MESH:D014212	5914	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Retinoic_acid-induced granulocytic differentiation of HL-60 myeloid_leukemia cells is mediated directly through the retinoic_acid receptor -LRB- RAR-alpha -RRB- .
7581005	0	retinoic_acid	35,48	RAR-beta	65,73	retinoic acid	RAR-beta	MESH:D014212	24706(Tax:10116)	Chemical	Gene	beta|amod|START_ENTITY beta|appos|END_ENTITY	Study of retinoic_acid effect upon retinoic_acid receptors beta -LRB- RAR-beta -RRB- in C6 cultured glioma cells .
10921005	0	retinoic_acid	54,67	RAR_alpha	77,86	retinoic acid	RAR alpha	MESH:D014212	5914	Chemical	Gene	-RSB-|amod|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Binding activity of retinoids with recombinant human retinoic_acid receptor RAR_alpha -RSB- .
8649786	0	retinoic_acid	112,125	RAR_alpha	64,73	retinoic acid	RAR alpha	MESH:D014212	5914	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Differential changes of retinoid-X-receptor -LRB- RXR_alpha -RRB- and its RAR_alpha and PML-RAR_alpha partners induced by retinoic_acid and cAMP distinguish maturation sensitive and resistant t -LRB- 15 ; 17 -RRB- _ promyelocytic_leukemia NB4 cells .
1725165	0	retinoic_acid	23,36	RAR_beta	47,55	retinoic acid	RAR beta	MESH:D014212	5915	Chemical	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Variable expression of retinoic_acid receptor -LRB- RAR_beta -RRB- mRNA in human oral and epidermal keratinocytes ; relation to keratin_19 expression and keratinization potential .
2844650	0	retinoic_acid	28,41	RAR_beta	51,59	retinoic acid	RAR beta	MESH:D014212	5915	Chemical	Gene	START_ENTITY|dobj|gene gene|compound|END_ENTITY	Assignment of the human hap retinoic_acid receptor RAR_beta gene to the p24 band of chromosome 3 .
8606853	0	retinoic_acid	19,32	RAR_beta	96,104	retinoic acid	RAR beta	MESH:D014212	24706(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|mRNA mRNA|compound|END_ENTITY	Postnatal rat lung retinoic_acid receptor -LRB- RAR -RRB- mRNA expression and effects of dexamethasone on RAR_beta mRNA .
19155306	0	retinoic_acid	107,120	RARalpha	142,150	retinoic acid	RARalpha	MESH:D014212	5914	Chemical	Gene	START_ENTITY|nmod|stabilization stabilization|nmod|END_ENTITY	Inhibition of the peptidyl-prolyl-isomerase Pin1 enhances the responses of acute_myeloid_leukemia cells to retinoic_acid via stabilization of RARalpha and PML-RARalpha .
9699718	0	retinoic_acid	5,18	RARalpha	36,44	retinoic acid	RARalpha	MESH:D014212	19401(Tax:10090)	Chemical	Gene	alpha|amod|START_ENTITY alpha|appos|END_ENTITY	Both retinoic_acid receptors alpha -LRB- RARalpha -RRB- and gamma -LRB- RARgamma -RRB- are able to initiate mouse upper-lip_skin_glandular_metaplasia .
15010078	0	retinoic_acid	27,40	RARbeta	56,63	retinoic acid	RARbeta	MESH:D014212	5915	Chemical	Gene	beta|amod|START_ENTITY beta|appos|END_ENTITY	Differential expression of retinoic_acid receptor beta -LRB- RARbeta -RRB- and the AP-1 transcription factor in normal , premalignant and malignant human laryngeal tissues .
20508731	0	retinoic_acid	24,37	RARbeta	53,60	retinoic acid	RARbeta	MESH:D014212	5915	Chemical	Gene	beta|amod|START_ENTITY beta|appos|END_ENTITY	Association analysis of retinoic_acid receptor beta -LRB- RARbeta -RRB- gene with high_myopia in Chinese subjects .
8650192	0	retinoic_acid	64,77	RIG-E	0,5	retinoic acid	RIG-E	MESH:D014212	4061	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	RIG-E , a human homolog of the murine Ly-6 family , is induced by retinoic_acid during the differentiation of acute_promyelocytic_leukemia cell .
17656367	0	retinoic_acid	112,125	RXR	162,165	retinoic acid	RXR	MESH:D014212	6256	Chemical	Gene	receptor|amod|START_ENTITY mechanism|nmod|receptor /|nsubj|mechanism /|dobj|heterodimer heterodimer|appos|END_ENTITY	p21WAF1/CIP1 is a common transcriptional target of retinoid receptors : pleiotropic regulatory mechanism through retinoic_acid receptor -LRB- RAR -RRB- / retinoid_X_receptor -LRB- RXR -RRB- heterodimer and RXR/RXR homodimer .
23392891	3	retinoic_acid	597,610	RXR	691,694	retinoic acid	VDR	MESH:D014212	396628(Tax:9823)	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|vitamin_D_receptor vitamin_D_receptor|appos|END_ENTITY	In this study , we test the hypothesis that the TauT gene is regulated by vitamin_D -LRB- 3 -RRB- -LRB- VD -LRB- 3 -RRB- -RRB- and retinoic_acid -LRB- RA -RRB- via activation of the vitamin_D_receptor -LRB- VDR -RRB- and retinoic_acid_receptor -LRB- RXR -RRB- .
7852380	0	retinoic_acid	11,24	RXR	61,64	retinoic acid	RXR	MESH:D014212	6256	Chemical	Gene	receptor|amod|START_ENTITY receptor|dep|retinoid_X_receptor retinoid_X_receptor|appos|END_ENTITY	Endogenous retinoic_acid receptor -LRB- RAR -RRB- - retinoid_X_receptor -LRB- RXR -RRB- heterodimers are the major functional forms regulating retinoid-responsive elements in adult human keratinocytes .
8025272	0	retinoic_acid	41,54	RXR	85,88	retinoic acid	RXR	MESH:D014212	6256	Chemical	Gene	receptor/retinoic|amod|START_ENTITY X_receptor|amod|receptor/retinoic X_receptor|appos|END_ENTITY	Myeloid differentiation mediated through retinoic_acid receptor/retinoic _ X_receptor -LRB- RXR -RRB- not RXR/RXR pathway .
8251184	0	retinoic_acid	39,52	Rar	21,24	retinoic acid	Rar	MESH:D014212	19401(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Mapping Mapping|nmod|encoding encoding|compound|END_ENTITY	Mapping of the mouse Rar loci encoding retinoic_acid receptors RAR_alpha , RAR_beta and RAR_gamma .
12123542	0	retinoic_acid	81,94	Retinoic_acid_receptor_beta	0,27	retinoic acid	Retinoic acid receptor beta	MESH:D014212	5915	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Retinoic_acid_receptor_beta is required for anti-activator_protein-1 activity by retinoic_acid in gastric_cancer cells .
24637840	0	retinoic_acid	36,49	SOX14	23,28	retinoic acid	SOX14	MESH:D014212	8403	Chemical	Gene	analysis|nmod|START_ENTITY analysis|nmod|END_ENTITY	Expression analysis of SOX14 during retinoic_acid induced neural differentiation of embryonal_carcinoma cells and assessment of the effect of its ectopic expression on SOXB members in HeLa cells .
17005281	0	retinoic_acid	53,66	SOX3	115,119	retinoic acid	SOX3	MESH:D014212	6658	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|gene gene|compound|END_ENTITY	Mapping of the RXRalpha binding elements involved in retinoic_acid induced transcriptional activation of the human SOX3 gene .
18786169	0	retinoic_acid	45,58	SOX3	21,25	retinoic acid	SOX3	MESH:D014212	6658	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Up-regulation of the SOX3 gene expression by retinoic_acid : characterization of the novel promoter-response element and the retinoid receptors involved .
12489526	0	retinoic_acid	84,97	STRA8	63,68	retinoic acid	STRA8	MESH:D014212	20899(Tax:10090)	Chemical	Gene	gene|compound|START_ENTITY stimulated|nmod|gene stimulated|nsubj|analysis analysis|nmod|gene gene|appos|END_ENTITY	Isolation and expression analysis of the testis-specific gene , STRA8 , stimulated by retinoic_acid gene 8 .
8089852	0	retinoic_acid	24,37	SmN	116,119	retinoic acid	SmN	MESH:D014212	64301(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Antagonistic effects of retinoic_acid and thyroid_hormone on the expression of the tissue-specific splicing protein SmN in a clonal cell line derived from rat heart .
20179325	0	retinoic_acid	77,90	Smad3	21,26	retinoic acid	Smad3	MESH:D014212	4088	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Transcription factor Smad3 is required for the inhibition of adipogenesis by retinoic_acid .
18032419	0	retinoic_acid	121,134	Stra8	50,55	retinoic acid	Stra8	MESH:D014212	20899(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY Expression|acl|induced Expression|acl|stimulated stimulated|nmod|gene gene|appos|END_ENTITY	Expression of stimulated by retinoic_acid gene 8 -LRB- Stra8 -RRB- and maturation of murine gonocytes and spermatogonia induced by retinoic_acid in vitro .
18032419	0	retinoic_acid	28,41	Stra8	50,55	retinoic acid	Stra8	MESH:D014212	20899(Tax:10090)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Expression of stimulated by retinoic_acid gene 8 -LRB- Stra8 -RRB- and maturation of murine gonocytes and spermatogonia induced by retinoic_acid in vitro .
18322276	0	retinoic_acid	28,41	Stra8	50,55	retinoic acid	Stra8	MESH:D014212	20899(Tax:10090)	Chemical	Gene	gene|amod|START_ENTITY stimulated|nmod|gene stimulated|dobj|8 8|appos|END_ENTITY	Expression of stimulated by retinoic_acid gene 8 -LRB- Stra8 -RRB- in spermatogenic cells induced by retinoic_acid : an in vivo study in vitamin_A-sufficient postnatal murine testes .
18322276	0	retinoic_acid	91,104	Stra8	50,55	retinoic acid	Stra8	MESH:D014212	20899(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY cells|acl|induced 8|nmod|cells 8|appos|END_ENTITY	Expression of stimulated by retinoic_acid gene 8 -LRB- Stra8 -RRB- in spermatogenic cells induced by retinoic_acid : an in vivo study in vitamin_A-sufficient postnatal murine testes .
15609095	0	retinoic_acid	18,31	TGF-beta2	51,60	retinoic acid	TGF-beta2	MESH:D014212	81809(Tax:10116)	Chemical	Gene	Teratogenicity|nmod|START_ENTITY Teratogenicity|nmod|expression expression|compound|END_ENTITY	Teratogenicity of retinoic_acid and its effects on TGF-beta2 expression in the developing cerebral cortex of the rat .
16479313	0	retinoic_acid	21,34	TGF-beta2	38,47	retinoic acid	TGF-beta2	MESH:D014212	81809(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effects of high dose retinoic_acid on TGF-beta2 expression during pancreatic organogenesis .
1879351	0	retinoic_acid	45,58	TGF_beta	22,30	retinoic acid	TGF beta	MESH:D014212	59086(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Complex regulation of TGF_beta expression by retinoic_acid in the vitamin_A-deficient rat .
12879006	0	retinoic_acid	65,78	TIG3	13,17	retinoic acid	TIG3	MESH:D014212	5920	Chemical	Gene	START_ENTITY|nsubj|Induction Induction|nmod|END_ENTITY	Induction of TIG3 , a putative class II tumor suppressor gene , by retinoic_acid in head and neck and lung_carcinoma cells and its association with suppression of the transformed phenotype .
11500296	0	retinoic_acid	37,50	TNF-alpha	19,28	retinoic acid	TNF-alpha	MESH:D014212	24835(Tax:10116)	Chemical	Gene	mRNA|nmod|START_ENTITY mRNA|amod|END_ENTITY	Destabilization of TNF-alpha mRNA by retinoic_acid in hepatic macrophages : implications for alcoholic_liver_disease .
11880314	0	retinoic_acid	19,32	TNF-alpha	66,75	retinoic acid	TNF-alpha	MESH:D014212	7124	Chemical	Gene	START_ENTITY|nmod|action action|nmod|END_ENTITY	Protective role of retinoic_acid from antiproliferative action of TNF-alpha on lung epithelial cells .
2826339	1	retinoic_acid	141,154	TNF-alpha	187,196	retinoic acid	IFN-gamma	MESH:D014212	3458	Chemical	Gene	combination|nmod|START_ENTITY combination|appos|END_ENTITY	The combination of retinoic_acid or tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- with interferon_gamma _ -LRB- IFN-gamma -RRB- resulted in a synergistic amplification of the anti-proliferative effect of IFN-gamma on cultured breast_cancer cells .
10393558	0	retinoic_acid	69,82	TR2-11	139,145	retinoic acid	TR2-11	MESH:D014212	22025(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Characterization of an inverted repeat with a zero spacer -LRB- IR0 -RRB- - type retinoic_acid response element from the mouse nuclear orphan receptor TR2-11 gene .
17634193	0	retinoic_acid	47,60	Tgf_beta	14,22	retinoic acid	Tgf beta	MESH:D014212	21803(Tax:10090)	Chemical	Gene	endogenous|acl|START_ENTITY signaling|nmod|endogenous END_ENTITY|acl|signaling	Inhibition of Tgf_beta signaling by endogenous retinoic_acid is essential for primary lung bud induction .
16713268	0	retinoic_acid	77,90	Thrombomodulin	0,14	retinoic acid	Thrombomodulin	MESH:D014212	7056	Chemical	Gene	analogues|amod|START_ENTITY cultured|nmod|analogues cultured|nsubj|induction induction|compound|END_ENTITY	Thrombomodulin induction in cultured human endothelial cells by 9-cis-locked retinoic_acid analogues .
9128763	0	retinoic_acid	85,98	Thrombomodulin	0,14	retinoic acid	Thrombomodulin	MESH:D014212	7056	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Thrombomodulin , a functional surface protein on human keratinocytes , is regulated by retinoic_acid .
11980848	0	retinoic_acid	37,50	VEGF	13,17	retinoic acid	VEGF	MESH:D014212	7422	Chemical	Gene	START_ENTITY|nsubj|Induction Induction|acl|END_ENTITY	Induction of VEGF gene expression by retinoic_acid through Sp1-binding sites in retinoblastoma Y79 cells .
19012162	0	retinoic_acid	11,24	Vangl1	47,53	retinoic acid	Vangl1	MESH:D014212	229658(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expressions expressions|nmod|END_ENTITY	Effects of retinoic_acid on the expressions of Vangl1 and vangl2 in mouse fetuses .
12239602	0	retinoic_acid	156,169	WNT10B	133,139	retinoic acid	WNT10B	MESH:D014212	7480	Chemical	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	Expression and regulation of WNT10B in human cancer : up-regulation of WNT10B in MCF-7 cells by beta-estradiol and down-regulation of WNT10B in NT2 cells by retinoic_acid .
6386496	0	retinoic_acid	47,60	acetylcholinesterase	14,34	retinoic acid	acetylcholinesterase	MESH:D014212	43	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|activity activity|amod|END_ENTITY	Regulation of acetylcholinesterase activity by retinoic_acid in a human neuroblastoma cell line .
1877746	0	retinoic_acid	84,97	alcohol_dehydrogenase	115,136	retinoic acid	alcohol dehydrogenase	MESH:D014212	10327	Chemical	Gene	synthesis|amod|START_ENTITY inhibition|nmod|synthesis involving|dobj|inhibition involving|nmod|step step|amod|END_ENTITY	A hypothetical mechanism for fetal_alcohol_syndrome involving ethanol inhibition of retinoic_acid synthesis at the alcohol_dehydrogenase step .
1996113	0	retinoic_acid	108,121	alcohol_dehydrogenase	44,65	retinoic acid	alcohol dehydrogenase	MESH:D014212	10327	Chemical	Gene	synthesis|amod|START_ENTITY regulation|nmod|synthesis implications|nmod|regulation element|dep|implications element|nmod|ADH3 ADH3|amod|END_ENTITY	Retinoic_acid response element in the human alcohol_dehydrogenase gene ADH3 : implications for regulation of retinoic_acid synthesis .
7748347	0	retinoic_acid	37,50	alcohol_dehydrogenase	12,33	retinoic acid	alcohol dehydrogenase	MESH:D014212	58810(Tax:10090)	Chemical	Gene	homeostasis|amod|START_ENTITY role|nmod|homeostasis role|nmod|END_ENTITY	The role of alcohol_dehydrogenase in retinoic_acid homeostasis and fetal_alcohol_syndrome .
8823154	0	retinoic_acid	173,186	alcohol_dehydrogenase	15,36	retinoic acid	alcohol dehydrogenase	MESH:D014212	10327	Chemical	Gene	synthesis|amod|START_ENTITY activation|nmod|synthesis signaling|nmod|activation Involvement|acl|signaling Involvement|nmod|END_ENTITY	Involvement of alcohol_dehydrogenase , short-chain dehydrogenase/reductase , aldehyde dehydrogenase , and cytochrome_P450 in the control of retinoid signaling by activation of retinoic_acid synthesis .
8892527	0	retinoic_acid	146,159	alcohol_dehydrogenase	115,136	retinoic acid	alcohol dehydrogenase	MESH:D014212	58810(Tax:10090)	Chemical	Gene	synthesis|amod|START_ENTITY END_ENTITY|nmod|synthesis	Expression patterns of class I and class IV alcohol_dehydrogenase genes in developing epithelia suggest a role for alcohol_dehydrogenase in local retinoic_acid synthesis .
9463728	0	retinoic_acid	61,74	alcohol_dehydrogenase	23,44	retinoic acid	alcohol dehydrogenase	MESH:D014212	10327	Chemical	Gene	treatment|amod|START_ENTITY END_ENTITY|nmod|treatment	Changes in human serum alcohol_dehydrogenase activity during retinoic_acid treatment of cancer patients .
8216300	0	retinoic_acid	35,48	alkaline_phosphatase	78,98	retinoic acid	alkaline phosphatase	MESH:D014212	250	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effects of synthetic retinoids and retinoic_acid isomers on the expression of alkaline_phosphatase in F9 teratocarcinoma cells .
10076999	0	retinoic_acid	43,56	alpha-1	66,73	retinoic acid	alpha-1	MESH:D014212	146	Chemical	Gene	promoter|amod|START_ENTITY promoter|amod|END_ENTITY	Estrogen receptor beta activates the human retinoic_acid receptor alpha-1 promoter in response to tamoxifen and other estrogen receptor antagonists , but not in response to estrogen .
11319755	0	retinoic_acid	65,78	alpha-smooth_muscle_actin	14,39	retinoic acid	alpha-smooth muscle actin	MESH:D014212	25365(Tax:10116)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of alpha-smooth_muscle_actin and CRBP-1 expression by retinoic_acid and TGF-beta in cultured fibroblasts .
21365646	0	retinoic_acid	45,58	alpha_fetoprotein	24,41	retinoic acid	alpha fetoprotein	MESH:D014212	174	Chemical	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Impact of intracellular alpha_fetoprotein on retinoic_acid receptors-mediated expression of GADD153 in human hepatoma cell lines .
10067845	0	retinoic_acid	74,87	androgen_receptor	13,30	retinoic acid	androgen receptor	MESH:D014212	367	Chemical	Gene	START_ENTITY|nsubj|Induction Induction|nmod|END_ENTITY	Induction of androgen_receptor by 1alpha,25-dihydroxyvitamin _ D3 and 9-cis retinoic_acid in LNCaP human prostate_cancer cells .
8943263	0	retinoic_acid	135,148	apolipoprotein_D	36,52	retinoic acid	apolipoprotein D	MESH:D014212	347	Chemical	Gene	RARalpha-dependent|amod|START_ENTITY mediated|nmod|RARalpha-dependent mediated|nsubjpass|expression expression|nmod|arrest arrest|compound|END_ENTITY	Retinoic_acid-induced expression of apolipoprotein_D and concomitant growth arrest in human breast_cancer cells are mediated through a retinoic_acid receptor RARalpha-dependent signaling pathway .
18636178	0	retinoic_acid	62,75	aquaporin_3	24,35	retinoic acid	aquaporin 3	MESH:D014212	360	Chemical	Gene	induced|nmod|START_ENTITY overexpression|acl|induced overexpression|amod|END_ENTITY	Nicotinamide attenuates aquaporin_3 overexpression induced by retinoic_acid through inhibition of EGFR/ERK in cultured human skin keratinocytes .
20178647	0	retinoic_acid	106,119	bcl-2	77,82	retinoic acid	bcl-2	MESH:D014212	596	Chemical	Gene	modulation|nmod|START_ENTITY modulation|amod|END_ENTITY	A randomized phase II trial of mitoxantrone , estramustine and vinorelbine or bcl-2 modulation with 13-cis retinoic_acid , interferon and paclitaxel in patients with metastatic castrate-resistant_prostate_cancer : ECOG 3899 .
7564507	0	retinoic_acid	68,81	bcl-2	41,46	retinoic acid	bcl-2	MESH:D014212	596	Chemical	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Direct evidence for the participation of bcl-2 in the regulation by retinoic_acid of the Ara-C sensitivity of leukemic stem cells .
11454993	0	retinoic_acid	40,53	beta2	63,68	retinoic acid	beta2	MESH:D014212	10242	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	The role of epigenetic modifications in retinoic_acid receptor beta2 gene expression in human prostate_cancers .
15219855	0	retinoic_acid	38,51	c-Jun	0,5	retinoic acid	c-Jun	MESH:D014212	16476(Tax:10090)	Chemical	Gene	induction|amod|START_ENTITY critical|nmod|induction critical|nsubj|END_ENTITY	c-Jun and Sp1 family are critical for retinoic_acid induction of the lamin_A / C retinoic_acid-responsive element .
1581607	0	retinoic_acid	56,69	c-Jun	39,44	retinoic acid	c-Jun	MESH:D014212	16476(Tax:10090)	Chemical	Gene	differentiation|amod|START_ENTITY inhibit|nmod|differentiation inhibit|dobj|induction induction|nmod|END_ENTITY	JunB does not inhibit the induction of c-Jun during the retinoic_acid induced differentiation of F9 cells .
1568207	3	retinoic_acid	481,494	c-fos	505,510	retinoic acid	c-fos	MESH:D014212	2353	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	In addition , nuclear run-on experiments showed that retinoic_acid regulated c-fos expression in SSV-NRK cells at the transcriptional initiation level .
1310930	0	retinoic_acid	48,61	c-jun	34,39	retinoic acid	c-jun	MESH:D014212	3725	Chemical	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Transcriptional regulation of the c-jun gene by retinoic_acid and E1A during differentiation of F9 cells .
1590797	0	retinoic_acid	97,110	c-jun	34,39	retinoic acid	c-jun	MESH:D014212	16476(Tax:10090)	Chemical	Gene	presence|nmod|START_ENTITY increased|nmod|presence increased|dobj|mRNA mRNA|amod|END_ENTITY	Activin synergistically increased c-jun mRNA in P19 embryonal_carcinoma cells in the presence of retinoic_acid .
1851295	0	retinoic_acid	36,49	c-jun	27,32	retinoic acid	c-jun	MESH:D014212	16476(Tax:10090)	Chemical	Gene	control|nmod|START_ENTITY control|nmod|END_ENTITY	Transcriptional control of c-jun by retinoic_acid .
9436983	0	retinoic_acid	66,79	c-jun	119,124	retinoic acid	c-jun	MESH:D014212	3725	Chemical	Gene	transcription|amod|START_ENTITY transcription|nmod|gene gene|amod|END_ENTITY	p300 and ATF-2 are components of the DRF complex , which regulates retinoic_acid - and E1A-mediated transcription of the c-jun gene in F9 cells .
15725648	0	retinoic_acid	22,35	cAMP-responsive_element_modulator	51,84	retinoic acid	cAMP-responsive element modulator	MESH:D014212	25620(Tax:10116)	Chemical	Gene	mRNA|amod|START_ENTITY mRNA|compound|END_ENTITY	The administration of retinoic_acid down-regulates cAMP-responsive_element_modulator -LRB- CREM -RRB- mRNA in vitamin_A-deficient testes .
16280361	0	retinoic_acid	23,36	cAMP_response_element-binding_protein	62,99	retinoic acid	cAMP response element-binding protein	MESH:D014212	1385	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Nonclassical action of retinoic_acid on the activation of the cAMP_response_element-binding_protein in normal human bronchial epithelial cells .
3032437	0	retinoic_acid	17,30	cRABP	48,53	retinoic acid	cRABP	MESH:D014212	1381	Chemical	Gene	START_ENTITY|dobj|protein protein|appos|END_ENTITY	Role of cellular retinoic_acid binding protein -LRB- cRABP -RRB- in patients with large_bowel_cancer .
7547509	0	retinoic_acid	60,73	cathepsin_D	14,25	retinoic acid	cathepsin D	MESH:D014212	1509	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of cathepsin_D gene expression in HL-60 cells by retinoic_acid and calcitriol .
21409183	0	retinoic_acid	118,131	cellular_retinoic_acid-binding_protein_I_and_II	14,61	retinoic acid	cellular retinoic acid-binding protein I and II	MESH:D014212	12903;12904	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|Expression Expression|nmod|END_ENTITY	Expression of cellular_retinoic_acid-binding_protein_I_and_II -LRB- CRABP_I and II -RRB- in embryonic mouse hearts treated with retinoic_acid .
1855468	0	retinoic_acid	20,33	cellular_retinol-binding_protein	55,87	retinoic acid	cellular retinol-binding protein	MESH:D014212	25056(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	Opposing effects of retinoic_acid and dexamethasone on cellular_retinol-binding_protein ribonucleic acid levels in the rat .
8262951	0	retinoic_acid	79,92	cellular_retinol-binding_protein	17,49	retinoic acid	cellular retinol-binding protein	MESH:D014212	537379(Tax:9913)	Chemical	Gene	synthesis|amod|START_ENTITY substrate|nmod|synthesis substrate|nsubj|Retinol Retinol|acl|bound bound|nmod|END_ENTITY	Retinol bound to cellular_retinol-binding_protein is a substrate for cytosolic retinoic_acid synthesis .
10329401	0	retinoic_acid	18,31	cholesteryl_ester_transfer_protein	58,92	retinoic acid	cholesteryl ester transfer protein	MESH:D014212	1071	Chemical	Gene	element|amod|START_ENTITY Identification|nmod|element Identification|nmod|gene gene|compound|END_ENTITY	Identification of retinoic_acid receptor element in human cholesteryl_ester_transfer_protein gene .
22485150	0	retinoic_acid	52,65	citrate_synthase	28,44	retinoic acid	citrate synthase	MESH:D014212	12974(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY END_ENTITY|nmod|receptor	Regulation of expression of citrate_synthase by the retinoic_acid receptor-related orphan receptor a -LRB- RORa -RRB- .
8806447	0	retinoic_acid	46,59	connexin31	14,24	retinoic acid	connexin31	MESH:D014212	29585(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY expression|nmod|treatment expression|amod|END_ENTITY	Regulation of connexin31 gene expression upon retinoic_acid treatment in rat_choriocarcinoma cells .
9428648	0	retinoic_acid	45,58	connexin43	62,72	retinoic acid	connexin43	MESH:D014212	14609(Tax:10090)	Chemical	Gene	Evidence|nmod|START_ENTITY Evidence|nmod|expression expression|amod|END_ENTITY	Evidence for a posttranscriptional effect of retinoic_acid on connexin43 gene expression via the 3 ' - untranslated region .
25877907	0	retinoic_acid	81,94	connexin_43	66,77	retinoic acid	connexin 43	MESH:D014212	2697	Chemical	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	A role for retinoids in human oocyte fertilization : regulation of connexin_43 by retinoic_acid in cumulus granulosa cells .
10919981	0	retinoic_acid	26,39	elastin	75,82	retinoic acid	elastin	MESH:D014212	13717(Tax:10090)	Chemical	Gene	receptors|amod|START_ENTITY deletions|nmod|receptors demonstrate|nsubj|deletions demonstrate|dobj|END_ENTITY	Mice bearing deletions of retinoic_acid receptors demonstrate reduced lung elastin and alveolar_numbers .
3499133	0	retinoic_acid	11,24	epidermal_growth_factor	42,65	retinoic acid	epidermal growth factor	MESH:D014212	13645(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|receptors receptors|nmod|END_ENTITY	Effects of retinoic_acid on receptors for epidermal_growth_factor in mouse palatal mesenchymal cells in vitro .
6288114	0	retinoic_acid	10,23	epidermal_growth_factor	84,107	retinoic acid	epidermal growth factor	MESH:D014212	1950	Chemical	Gene	Effect|acl|START_ENTITY Effect|nmod|binding binding|nmod|END_ENTITY	Effect of retinoic_acid and 12-O-tetradecanoyl_phorbol-13-acetate on the binding of epidermal_growth_factor to its cellular receptors .
1389683	0	retinoic_acid	15,28	epidermal_growth_factor_receptor	32,64	retinoic acid	epidermal growth factor receptor	MESH:D014212	1956	Chemical	Gene	Suppression|nmod|START_ENTITY Suppression|nmod|autophosphorylation autophosphorylation|compound|END_ENTITY	Suppression by retinoic_acid of epidermal_growth_factor_receptor autophosphorylation and glycosylation in cultured human head and neck squamous_carcinoma cells .
14519647	0	retinoic_acid	22,35	epidermal_growth_factor_receptor	135,167	retinoic acid	epidermal growth factor receptor	MESH:D014212	1956	Chemical	Gene	receptor-selective|amod|START_ENTITY Responsiveness|nmod|receptor-selective Responsiveness|parataxis|signaling signaling|nsubj|autocrine autocrine|compound|END_ENTITY	Responsiveness to the retinoic_acid receptor-selective retinoid LGD1550 correlates with abrogation of transforming_growth_factor_alpha / epidermal_growth_factor_receptor autocrine signaling in head and neck squamous_carcinoma cells .
1515368	0	retinoic_acid	63,76	epidermal_growth_factor_receptor	27,59	retinoic acid	epidermal growth factor receptor	MESH:D014212	1956	Chemical	Gene	control|nmod|START_ENTITY control|nmod|END_ENTITY	Transcriptional control of epidermal_growth_factor_receptor by retinoic_acid .
2288880	0	retinoic_acid	66,79	epidermal_growth_factor_receptor	20,52	retinoic acid	epidermal growth factor receptor	MESH:D014212	24329(Tax:10116)	Chemical	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	Characterization of epidermal_growth_factor_receptor induction by retinoic_acid in a chemically transformed rat liver cell line .
2575317	0	retinoic_acid	7,20	epidermal_growth_factor_receptor	71,103	retinoic acid	epidermal growth factor receptor	MESH:D014212	1956	Chemical	Gene	modulate|nsubj|START_ENTITY modulate|dobj|expression expression|nmod|protein protein|amod|END_ENTITY	13-cis retinoic_acid and dexamethasone modulate the gene expression of epidermal_growth_factor_receptor and fibroblast proteoglycan 40 core protein in human skin fibroblasts .
2783693	0	retinoic_acid	66,79	epidermal_growth_factor_receptor	14,46	retinoic acid	epidermal growth factor receptor	MESH:D014212	24329(Tax:10116)	Chemical	Gene	factor|amod|START_ENTITY Regulation|nmod|factor Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of epidermal_growth_factor_receptor gene expression by retinoic_acid and epidermal growth factor .
9191201	0	retinoic_acid	46,59	fatty_acid_synthase	18,37	retinoic acid	fatty acid synthase	MESH:D014212	2194	Chemical	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Regulation of the fatty_acid_synthase gene by retinoic_acid in HepG2 cells is mediated by an E-box-containing multihormonal response element and two neighbouring upstream sequences .
10385401	0	retinoic_acid	10,23	glucokinase	27,38	retinoic acid	glucokinase	MESH:D014212	24385(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effect of retinoic_acid on glucokinase activity and gene expression and on insulin secretion in primary cultures of pancreatic islets .
11432447	0	retinoic_acid	10,23	glucokinase	27,38	retinoic acid	glucokinase	MESH:D014212	24385(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effect of retinoic_acid on glucokinase activity and gene expression in neonatal and adult cultured hepatocytes .
1537314	0	retinoic_acid	114,127	glucokinase	14,25	retinoic acid	glucokinase	MESH:D014212	24385(Tax:10116)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Regulation Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of glucokinase and proinsulin gene expression and insulin secretion in RIN-m5F cells by dexamethasone , retinoic_acid , and thyroid hormone .
1315523	0	retinoic_acid	30,43	glutathione_S-transferase	58,83	retinoic acid	glutathione S-transferase	MESH:D014212	373156	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Glucocorticoid , androgen , and retinoic_acid regulation of glutathione_S-transferase gene expression in hamster smooth muscle_tumor cells .
9641219	0	retinoic_acid	11,24	gp96	92,96	retinoic acid	gp96	MESH:D014212	7184	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of retinoic_acid on the expression of a tumor_rejection_antigen -LRB- heat_shock protein gp96 -RRB- in human cervical_cancer .
23136256	0	retinoic_acid	75,88	granulocyte-colony_stimulating_factor_receptor	4,50	retinoic acid	granulocyte-colony stimulating factor receptor	MESH:D014212	12986(Tax:10090)	Chemical	Gene	receptors|amod|START_ENTITY interacts|nmod|receptors interacts|nsubj|END_ENTITY	The granulocyte-colony_stimulating_factor_receptor -LRB- G-CSFR -RRB- interacts with retinoic_acid receptors -LRB- RARs -RRB- in the regulation of myeloid differentiation .
1464411	0	retinoic_acid	40,53	growth_hormone	75,89	retinoic acid	growth hormone	MESH:D014212	81668(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|synthesis synthesis|amod|END_ENTITY	Comparative effects of thyroxine and/or retinoic_acid treatment in vivo on growth_hormone synthesis and release by pituitaries from thyroidectomized rats .
7956917	0	retinoic_acid	6,19	growth_hormone	38,52	retinoic acid	growth hormone	MESH:D014212	81668(Tax:10116)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	9-cis retinoic_acid regulation of rat growth_hormone gene expression : potential roles of multiple nuclear hormone receptors .
8243317	0	retinoic_acid	69,82	growth_hormone	29,43	retinoic acid	growth hormone	MESH:D014212	14599(Tax:10090)	Chemical	Gene	regulation|nmod|START_ENTITY express|dep|regulation express|dobj|receptors receptors|amod|END_ENTITY	Embryonic stem cells express growth_hormone receptors : regulation by retinoic_acid .
2546152	0	retinoic_acid	14,27	hRAR-gamma	38,48	retinoic acid	hRAR-gamma	MESH:D014212	5916	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	A third human retinoic_acid receptor , hRAR-gamma .
7821715	0	retinoic_acid	86,99	homodimer	151,160	retinoic acid	homodimer	MESH:D014212	6647	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Quantitative increases in DNA binding affinity and positional effects determine 9-cis retinoic_acid induced activation of the retinoid_X_receptor_beta homodimer .
9853959	0	retinoic_acid	34,47	hoxb2	22,27	retinoic acid	hoxb2	MESH:D014212	30338(Tax:7955)	Chemical	Gene	treatment|amod|START_ENTITY END_ENTITY|nmod|treatment	Ectopic expression of hoxb2 after retinoic_acid treatment or mRNA injection : disruption of hindbrain and craniofacial morphogenesis in zebrafish embryos .
14702176	0	retinoic_acid	65,78	iNOS	18,22	retinoic acid	iNOS	MESH:D014212	18126(Tax:10090)	Chemical	Gene	Overexpression|nmod|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of iNOS and down-regulation of BMPs-2 , 4 and 7 in retinoic_acid induced cleft_palate formation .
12169446	0	retinoic_acid	55,68	inducible_NO_synthase	19,40	retinoic acid	inducible NO synthase	MESH:D014212	24599(Tax:10116)	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Enhancement of the inducible_NO_synthase activation by retinoic_acid is mimicked by RARalpha agonist in vivo .
24583012	0	retinoic_acid	37,50	insulin	18,25	retinoic acid	insulin	MESH:D014212	3630	Chemical	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification of insulin as a novel retinoic_acid receptor-related orphan receptor a target gene .
7647034	0	retinoic_acid	14,27	intercellular_adhesion_molecule-1	110,143	retinoic acid	intercellular adhesion molecule-1	MESH:D014212	3383	Chemical	Gene	START_ENTITY|ccomp|stimulate stimulate|dobj|expression expression|nmod|gene gene|amod|END_ENTITY	Heterodimeric retinoic_acid receptor-beta and retinoid_X receptor-alpha complexes stimulate expression of the intercellular_adhesion_molecule-1 gene .
7914515	0	retinoic_acid	62,75	intercellular_adhesion_molecule-1	14,47	retinoic acid	intercellular adhesion molecule-1	MESH:D014212	3383	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of intercellular_adhesion_molecule-1 expression by retinoic_acid : analysis of the 5 ' regulatory region of the gene .
1673449	0	retinoic_acid	53,66	interferon-gamma	11,27	retinoic acid	interferon-gamma	MESH:D014212	3458	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of interferon-gamma and its interaction with retinoic_acid on human neuroblastoma differentiation .
7578267	0	retinoic_acid	77,90	interferon-gamma	23,39	retinoic acid	interferon-gamma	MESH:D014212	3458	Chemical	Gene	2-vitamin_D3|compound|START_ENTITY oxidase|nmod|2-vitamin_D3 oxidase|nsubj|effects effects|nmod|END_ENTITY	Cooperative effects of interferon-gamma on the induction of NADPH oxidase by retinoic_acid or 1,25 -LRB- OH -RRB- 2-vitamin_D3 in monocytic U937 cells .
9462716	0	retinoic_acid	11,24	interferon-gamma	39,55	retinoic acid	interferon-gamma	MESH:D014212	3458	Chemical	Gene	Effects|nmod|START_ENTITY combined|nsubj|Effects combined|nmod|END_ENTITY	Effects of retinoic_acid combined with interferon-gamma on the expression of major-histocompatibility-complex molecules and intercellular adhesion molecule-1 in human cervical_cancer .
8083217	0	retinoic_acid	52,65	interleukin-1	19,32	retinoic acid	interleukin-1	MESH:D014212	3552	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Induction of human interleukin-1 gene expression by retinoic_acid and its regulation at processing of precursor transcripts .
3931632	0	retinoic_acid	49,62	interleukin_1_and_3	15,34	retinoic acid	interleukin 1 and 3	MESH:D014212	16187(Tax:10090)	Chemical	Gene	Stimulation|nmod|START_ENTITY Stimulation|nmod|production production|amod|END_ENTITY	Stimulation of interleukin_1_and_3 production by retinoic_acid in vitro .
8734361	0	retinoic_acid	15,28	interleukin_6	66,79	retinoic acid	interleukin 6	MESH:D014212	3569	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|role role|nmod|END_ENTITY	The effects of retinoic_acid on immunoglobulin synthesis : role of interleukin_6 .
8959344	0	retinoic_acid	44,57	involucrin	14,24	retinoic acid	involucrin	MESH:D014212	3713	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of involucrin gene expression by retinoic_acid and glucocorticoids .
1850696	0	retinoic_acid	9,22	laminin_B1	36,46	retinoic acid	laminin B1	MESH:D014212	16777(Tax:10090)	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|transcription transcription|amod|END_ENTITY	The late retinoic_acid induction of laminin_B1 gene transcription involves RAR binding to the responsive element .
8350952	0	retinoic_acid	129,142	leukosialin	14,25	retinoic acid	leukosialin	MESH:D014212	105369261	Chemical	Gene	START_ENTITY|nsubj|Modulation Modulation|nmod|END_ENTITY	Modulation of leukosialin -LRB- sialophorin , CD43 antigen -RRB- on the cell surface of human hematopoietic cell lines induced by cytokins , retinoic_acid and 1,25 -LRB- OH -RRB- 2-vitamin_D3 .
16448226	0	retinoic_acid	136,149	lif	112,115	retinoic acid	lif	MESH:D014212	16878(Tax:10090)	Chemical	Gene	effects|acl|START_ENTITY effects|nmod|END_ENTITY	Self-renewal and differentiation of mouse embryonic stem cells as measured by Oct_4 gene expression : effects of lif , serum-free medium , retinoic_acid , and dbcAMP .
8442757	0	retinoic_acid	11,24	lipoprotein_lipase	28,46	retinoic acid	lipoprotein lipase	MESH:D014212	4023	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effects of retinoic_acid on lipoprotein_lipase activity and mRNA level in vitro and in vivo .
25241363	0	retinoic_acid	72,85	mammalian_target_of_rapamycin	14,43	retinoic acid	mammalian target of rapamycin	MESH:D014212	2475	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of mammalian_target_of_rapamycin signaling pathway decreases retinoic_acid stimulated gene 8 expression in adult mouse testis .
1846233	0	retinoic_acid	11,24	melanoma-associated_antigen	56,83	retinoic acid	melanoma-associated antigen	MESH:D014212	57730	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|amod|END_ENTITY	Effects of retinoic_acid and bromodeoxyuridine on human melanoma-associated_antigen expression in small_cell_lung_carcinoma cells .
10024510	0	retinoic_acid	73,86	mucin	48,53	retinoic acid	mucin	MESH:D014212	100508689	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Role of retinoid receptors in the regulation of mucin gene expression by retinoic_acid in human tracheobronchial epithelial cells .
10855573	0	retinoic_acid	86,99	mucin	115,120	retinoic acid	mucin	MESH:D014212	100508689	Chemical	Gene	differentiation|nmod|START_ENTITY differentiation|dep|expression expression|nmod|END_ENTITY	Secretory differentiation of serially passaged normal human nasal epithelial cells by retinoic_acid : expression of mucin and lysozyme .
11200589	0	retinoic_acid	11,24	mucin	65,70	retinoic acid	mucin	MESH:D014212	100508689	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of retinoic_acid , triiodothyronine and hydrocortisone on mucin and lysozyme expression in cultured human middle ear epithelial cells .
17646388	0	retinoic_acid	63,76	mucin	14,19	retinoic acid	mucin	MESH:D014212	100508689	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of mucin gene expression by CREB via a nonclassical retinoic_acid signaling pathway .
8297336	0	retinoic_acid	10,23	mucin	27,32	retinoic acid	mucin	MESH:D014212	65202(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effect of retinoic_acid on mucin gene expression in rat airways in vitro .
9870916	0	retinoic_acid	39,52	mucin	117,122	retinoic acid	mucin	MESH:D014212	100508689	Chemical	Gene	cultures|amod|START_ENTITY phenotype|nmod|cultures Restoration|nmod|phenotype Restoration|dep|changes changes|nmod|expression expression|amod|END_ENTITY	Restoration of the mucous phenotype by retinoic_acid in retinoid-deficient human bronchial cell cultures : changes in mucin gene expression .
3030555	0	retinoic_acid	10,23	nerve_growth_factor	27,46	retinoic acid	nerve growth factor	MESH:D014212	4803	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|receptors receptors|compound|END_ENTITY	Effect of retinoic_acid on nerve_growth_factor receptors .
1446821	0	retinoic_acid	71,84	nerve_growth_factor_receptor	96,124	retinoic acid	nerve growth factor receptor	MESH:D014212	24596(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|promoter promoter|compound|END_ENTITY	Regulatory elements and transcriptional regulation by testosterone and retinoic_acid of the rat nerve_growth_factor_receptor promoter .
7972206	0	retinoic_acid	74,87	nerve_growth_factor_receptor	14,42	retinoic acid	nerve growth factor receptor	MESH:D014212	4804	Chemical	Gene	Expression|acl|START_ENTITY Expression|nmod|mRNAs mRNAs|compound|END_ENTITY	Expression of nerve_growth_factor_receptor mRNAs and clinical response to retinoic_acid in neuroblastoma .
10222420	0	retinoic_acid	103,116	neural_cell_adhesion_molecule	130,159	retinoic acid	neural cell adhesion molecule	MESH:D014212	4684	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Paucity of retinoic_acid_receptor_alpha -LRB- RAR_alpha -RRB- nuclear immunostaining in gliomas and inability of retinoic_acid to influence neural_cell_adhesion_molecule -LRB- NCAM -RRB- expression .
18602376	0	retinoic_acid	15,28	neurogranin	50,61	retinoic acid	neurogranin	MESH:D014212	64356(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	The effects of retinoic_acid on the expression of neurogranin after experimental cerebral_ischemia .
3349487	0	retinoic_acid	193,206	ornithine_decarboxylase	97,120	retinoic acid	ornithine decarboxylase	MESH:D014212	18263(Tax:10090)	Chemical	Gene	promoter|nmod|START_ENTITY promoter|dobj|synthesis synthesis|nmod|RNA RNA|amod|END_ENTITY	Inhibition of tumor promoter 12-O-tetradecanoylphorbol-13-acetate-induced synthesis of epidermal ornithine_decarboxylase messenger RNA and diacylglycerol-promoted mouse skin_tumor formation by retinoic_acid .
4053280	0	retinoic_acid	26,39	ornithine_decarboxylase	119,142	retinoic acid	ornithine decarboxylase	MESH:D014212	4953	Chemical	Gene	Dose|nmod|START_ENTITY needed|nsubj|Dose needed|xcomp|inhibit inhibit|dobj|activity activity|compound|END_ENTITY	Dose and schedule of oral retinoic_acid and indomethacin needed to effectively inhibit phorbol_ester-induced epidermal ornithine_decarboxylase activity .
7448775	0	retinoic_acid	13,26	ornithine_decarboxylase	41,64	retinoic acid	ornithine decarboxylase	MESH:D014212	18263(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|inhibition inhibition|nmod|induction induction|amod|END_ENTITY	Differential retinoic_acid inhibition of ornithine_decarboxylase induction by 12-O-tetradecanoylphorbol-13-acetate and by germicidal ultraviolet light .
12139723	0	retinoic_acid	25,38	p53	191,194	retinoic acid	p53	MESH:D014212	7157	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nsubj|effect	Superior effect of 9-cis retinoic_acid -LRB- RA -RRB- compared with all-trans_RA and 13-cis RA on the inhibition of clonogenic cell growth and the induction of apoptosis in OCI/AML -2 subclones : is the p53 pathway involved ?
15790450	0	retinoic_acid	69,82	p53	111,114	retinoic acid	p53	MESH:D014212	7157	Chemical	Gene	radiation|nmod|START_ENTITY lines|nmod|radiation Sensitization|nmod|lines require|nsubj|Sensitization require|dobj|END_ENTITY	Sensitization of cervical cancer cell lines to low-dose radiation by retinoic_acid does not require functional p53 .
8082749	0	retinoic_acid	96,109	p53	27,30	retinoic acid	p53	MESH:D014212	7157	Chemical	Gene	arrested|nmod|START_ENTITY arrested|nsubj|stabilization stabilization|nmod|END_ENTITY	Transient stabilization of p53 in non-small_cell_lung_carcinoma cultures arrested for growth by retinoic_acid .
1333043	0	retinoic_acid	106,119	phosphoenolpyruvate_carboxykinase	18,51	retinoic acid	phosphoenolpyruvate carboxykinase	MESH:D014212	5106	Chemical	Gene	complex|amod|START_ENTITY dependent|nmod|complex retinoic_acid|ccomp|dependent retinoic_acid|nsubj|Activation Activation|nmod|gene gene|amod|END_ENTITY	Activation of the phosphoenolpyruvate_carboxykinase gene retinoic_acid response element is dependent on a retinoic_acid receptor/coregulator complex .
1333043	0	retinoic_acid	57,70	phosphoenolpyruvate_carboxykinase	18,51	retinoic acid	phosphoenolpyruvate carboxykinase	MESH:D014212	5106	Chemical	Gene	START_ENTITY|nsubj|Activation Activation|nmod|gene gene|amod|END_ENTITY	Activation of the phosphoenolpyruvate_carboxykinase gene retinoic_acid response element is dependent on a retinoic_acid receptor/coregulator complex .
16713227	0	retinoic_acid	32,45	phosphoenolpyruvate_carboxykinase	71,104	retinoic acid	phosphoenolpyruvate carboxykinase	MESH:D014212	18534(Tax:10090)	Chemical	Gene	elements|amod|START_ENTITY receptor|nmod|elements receptor|nmod|gene gene|amod|END_ENTITY	Nuclear receptor binding to the retinoic_acid response elements of the phosphoenolpyruvate_carboxykinase gene in vivo : effects of vitamin_A_deficiency .
1848696	0	retinoic_acid	2,15	phosphoenolpyruvate_carboxykinase	72,105	retinoic acid	phosphoenolpyruvate carboxykinase	MESH:D014212	5106	Chemical	Gene	element|amod|START_ENTITY part|nsubj|element part|nmod|domain domain|nmod|gene gene|amod|END_ENTITY	A retinoic_acid response element is part of a pleiotropic domain in the phosphoenolpyruvate_carboxykinase gene .
2176887	0	retinoic_acid	66,79	phosphoenolpyruvate_carboxykinase	13,46	retinoic acid	phosphoenolpyruvate carboxykinase	MESH:D014212	362282(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Induction of phosphoenolpyruvate_carboxykinase gene expression by retinoic_acid in an adult rat hepatocyte line .
9078282	0	retinoic_acid	99,112	phosphoenolpyruvate_carboxykinase	126,159	retinoic acid	phosphoenolpyruvate carboxykinase	MESH:D014212	5106	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|transcription transcription|amod|END_ENTITY	CCAAT-enhancer-binding_protein alpha -LRB- C/EBP _ alpha -RRB- is required for the thyroid hormone but not the retinoic_acid induction of phosphoenolpyruvate_carboxykinase -LRB- PEPCK -RRB- gene transcription .
11358286	0	retinoic_acid	10,23	phospholipase_A2	48,64	retinoic acid	phospholipase A2	MESH:D014212	151056	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|END_ENTITY	Effect of retinoic_acid on the Ca2 + - independent phospholipase_A2 in nuclei of LA-N-1 neuroblastoma cells .
22125274	0	retinoic_acid	79,92	pitx2	59,64	retinoic acid	pitx2	MESH:D014212	30164(Tax:7955)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	A zebrafish model of axenfeld-rieger_syndrome reveals that pitx2 regulation by retinoic_acid is essential for ocular and craniofacial development .
1324146	0	retinoic_acid	79,92	prolactin	44,53	retinoic acid	prolactin	MESH:D014212	5617	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|gene gene|compound|END_ENTITY	Posttranscriptional regulation of the human prolactin gene in IM-9-P3 cells by retinoic_acid .
17151246	0	retinoic_acid	39,52	receptor_C	77,87	retinoic acid	receptor C	MESH:D014212	527470(Tax:9913)	Chemical	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	The effect of genetic variation of the retinoic_acid receptor-related orphan receptor_C gene on fatness in cattle .
19820062	0	retinoic_acid	31,44	receptor_C	69,79	retinoic acid	receptor C	MESH:D014212	527470(Tax:9913)	Chemical	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	The effect of variation at the retinoic_acid receptor-related orphan receptor_C gene on intramuscular fat percent and marbling score in Australian cattle .
20736163	0	retinoic_acid	134,147	retinoic_acid_receptor	32,54	retinoic acid	retinoic acid receptor	MESH:D014212	5914	Chemical	Gene	absence|nmod|START_ENTITY adaptor|nmod|absence adaptor|nmod|END_ENTITY	A novel cytoplasmic adaptor for retinoic_acid_receptor -LRB- RAR -RRB- and thyroid receptor functions as a Derepressor of RAR in the absence of retinoic_acid .
1661301	0	retinoic_acid	10,23	retinoic_acid_receptor-alpha	38,66	retinoic acid	retinoic acid receptor-alpha	MESH:D014212	5914	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	All-trans retinoic_acid modulates the retinoic_acid_receptor-alpha in promyelocytic cells .
8260698	0	retinoic_acid	17,30	retinoic_acid_receptor-alpha	115,143	retinoic acid	retinoic acid receptor-alpha	MESH:D014212	5914	Chemical	Gene	START_ENTITY|nmod|proliferation proliferation|nmod|RNA RNA|amod|END_ENTITY	Effects of novel retinoic_acid compound , 9-cis-retinoic_acid , on proliferation , differentiation , and expression of retinoic_acid_receptor-alpha and retinoid_X_receptor-alpha RNA by HL-60 cells .
10222420	0	retinoic_acid	103,116	retinoic_acid_receptor_alpha	11,39	retinoic acid	retinoic acid receptor alpha	MESH:D014212	5914	Chemical	Gene	expression|amod|START_ENTITY immunostaining|nmod|expression Paucity|dep|immunostaining Paucity|nmod|END_ENTITY	Paucity of retinoic_acid_receptor_alpha -LRB- RAR_alpha -RRB- nuclear immunostaining in gliomas and inability of retinoic_acid to influence neural_cell_adhesion_molecule -LRB- NCAM -RRB- expression .
11819850	0	retinoic_acid	22,35	retinoic_acid_receptor_alpha	58,86	retinoic acid	retinoic acid receptor alpha	MESH:D014212	5914	Chemical	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	The effect pathway of retinoic_acid through regulation of retinoic_acid_receptor_alpha in gastric_cancer cells .
12009305	0	retinoic_acid	21,34	retinoic_acid_receptor_alpha	79,107	retinoic acid	retinoic acid receptor alpha	MESH:D014212	5914	Chemical	Gene	effect|nmod|START_ENTITY mediated|nsubjpass|effect mediated|nmod|END_ENTITY	Anticancer effect of retinoic_acid via AP-1 activity repression is mediated by retinoic_acid_receptor_alpha and beta in gastric_cancer cells .
1336976	0	retinoic_acid	93,106	retinoic_acid_receptor_alpha	16,44	retinoic acid	retinoic acid receptor alpha	MESH:D014212	399081(Tax:8355)	Chemical	Gene	respond|xcomp|START_ENTITY respond|nsubj|isoforms isoforms|nmod|END_ENTITY	Two isoforms of retinoic_acid_receptor_alpha expressed during Xenopus development respond to retinoic_acid .
17035595	0	retinoic_acid	9,22	retinoic_acid_receptor_alpha	80,108	retinoic acid	retinoic acid receptor alpha	MESH:D014212	19401(Tax:10090)	Chemical	Gene	determines|nsubj|START_ENTITY determines|dobj|integrity integrity|dep|Role Role|nmod|agonists agonists|compound|END_ENTITY	Cellular retinoic_acid bioavailability determines epithelial integrity : Role of retinoic_acid_receptor_alpha agonists in colitis .
17786207	0	retinoic_acid	79,92	retinoic_acid_receptor_alpha	14,42	retinoic acid	retinoic acid receptor alpha	MESH:D014212	5914	Chemical	Gene	face|nmod|START_ENTITY reveals|dobj|face reveals|nsubj|Disruption Disruption|nmod|END_ENTITY	Disruption of retinoic_acid_receptor_alpha reveals the growth promoter face of retinoic_acid .
18048326	0	retinoic_acid	18,31	retinoic_acid_receptor_alpha	99,127	retinoic acid	retinoic acid receptor alpha	MESH:D014212	5914	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Identification of retinoic_acid as an inhibitor of transcription factor Nrf2 through activation of retinoic_acid_receptor_alpha .
1846598	0	retinoic_acid	128,141	retinoic_acid_receptor_alpha	31,59	retinoic acid	retinoic acid receptor alpha	MESH:D014212	19401(Tax:10090)	Chemical	Gene	generated|nmod|START_ENTITY generated|nsubjpass|isoforms isoforms|nmod|END_ENTITY	Multiple isoforms of the mouse retinoic_acid_receptor_alpha are generated by alternative splicing and differential induction by retinoic_acid .
7934625	0	retinoic_acid	68,81	retinoic_acid_receptor_alpha	102,130	retinoic acid	retinoic acid receptor alpha	MESH:D014212	19401(Tax:10090)	Chemical	Gene	caused|nmod|START_ENTITY cells|acl|caused differentiation|nmod|cells prevention|nmod|differentiation elicited|nsubjpass|prevention elicited|nmod|END_ENTITY	The prevention of adipose differentiation of 3T3-L1 cells caused by retinoic_acid is elicited through retinoic_acid_receptor_alpha .
8702769	0	retinoic_acid	61,74	retinoic_acid_receptor_alpha	23,51	retinoic acid	retinoic acid receptor alpha	MESH:D014212	5914	Chemical	Gene	inhibition|amod|START_ENTITY mediates|dobj|inhibition mediates|nsubj|region region|nmod|END_ENTITY	The AF-2 region of the retinoic_acid_receptor_alpha mediates retinoic_acid inhibition of estrogen receptor function in breast_cancer cells .
8947586	0	retinoic_acid	111,124	retinoic_acid_receptor_alpha	45,73	retinoic acid	retinoic acid receptor alpha	MESH:D014212	5914	Chemical	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	Mutation in the ligand-binding domain of the retinoic_acid_receptor_alpha in HL-60 leukemic cells resistant to retinoic_acid and with increased sensitivity to vitamin_D3 analogs .
11058790	0	retinoic_acid	10,23	retinoic_acid_receptor_beta	39,66	retinoic acid	retinoic acid receptor beta	MESH:D014212	5915	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of retinoic_acid and ethanol on retinoic_acid_receptor_beta and glial_fibrillary_acidic_protein mRNA expression in human astrocytoma cells .
7852380	0	retinoic_acid	11,24	retinoid_X_receptor	40,59	retinoic acid	retinoid X receptor	MESH:D014212	6256	Chemical	Gene	receptor|amod|START_ENTITY receptor|dep|END_ENTITY	Endogenous retinoic_acid receptor -LRB- RAR -RRB- - retinoid_X_receptor -LRB- RXR -RRB- heterodimers are the major functional forms regulating retinoid-responsive elements in adult human keratinocytes .
11036068	0	retinoic_acid	53,66	thrombomodulin	16,30	retinoic acid	thrombomodulin	MESH:D014212	7056	Chemical	Gene	transcription|nmod|START_ENTITY transcription|nsubj|Acceleration Acceleration|nmod|gene gene|compound|END_ENTITY	Acceleration of thrombomodulin gene transcription by retinoic_acid : retinoic_acid receptors and Sp1 regulate the promoter activity through interactions with two different sequences in the 5 ' - flanking region of human gene .
11036068	0	retinoic_acid	68,81	thrombomodulin	16,30	retinoic acid	thrombomodulin	MESH:D014212	7056	Chemical	Gene	receptors|amod|START_ENTITY regulate|nsubj|receptors transcription|parataxis|regulate transcription|nsubj|Acceleration Acceleration|nmod|gene gene|compound|END_ENTITY	Acceleration of thrombomodulin gene transcription by retinoic_acid : retinoic_acid receptors and Sp1 regulate the promoter activity through interactions with two different sequences in the 5 ' - flanking region of human gene .
1370608	1	retinoic_acid	181,194	thrombomodulin	163,177	retinoic acid	thrombomodulin	MESH:D014212	7056	Chemical	Gene	Differences|nmod|START_ENTITY Differences|nmod|END_ENTITY	Differences between up-regulation of thrombomodulin by retinoic_acid and cyclic_AMP .
8207015	0	retinoic_acid	61,74	thrombomodulin	143,157	retinoic acid	thrombomodulin	MESH:D014212	7056	Chemical	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|element element|nmod|gene gene|compound|END_ENTITY	Characterization of thrombomodulin expression in response to retinoic_acid and identification of a retinoic_acid response element in the human thrombomodulin gene .
8207015	0	retinoic_acid	61,74	thrombomodulin	20,34	retinoic acid	thrombomodulin	MESH:D014212	7056	Chemical	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|expression expression|compound|END_ENTITY	Characterization of thrombomodulin expression in response to retinoic_acid and identification of a retinoic_acid response element in the human thrombomodulin gene .
8207015	0	retinoic_acid	99,112	thrombomodulin	143,157	retinoic acid	thrombomodulin	MESH:D014212	7056	Chemical	Gene	element|amod|START_ENTITY element|nmod|gene gene|compound|END_ENTITY	Characterization of thrombomodulin expression in response to retinoic_acid and identification of a retinoic_acid response element in the human thrombomodulin gene .
8207015	0	retinoic_acid	99,112	thrombomodulin	20,34	retinoic acid	thrombomodulin	MESH:D014212	7056	Chemical	Gene	element|amod|START_ENTITY Characterization|nmod|element Characterization|nmod|expression expression|compound|END_ENTITY	Characterization of thrombomodulin expression in response to retinoic_acid and identification of a retinoic_acid response element in the human thrombomodulin gene .
1935958	0	retinoic_acid	10,23	tissue-type_plasminogen_activator	44,77	retinoic acid	tissue-type plasminogen activator	MESH:D014212	5327	Chemical	Gene	START_ENTITY|nmod|synthesis synthesis|nmod|END_ENTITY	Effect of retinoic_acid on the synthesis of tissue-type_plasminogen_activator and plasminogen_activator_inhibitor-1 in human endothelial cells .
8695801	0	retinoic_acid	113,126	tissue-type_plasminogen_activator	15,48	retinoic acid	tissue-type plasminogen activator	MESH:D014212	5327	Chemical	Gene	induction|amod|START_ENTITY requires|dobj|induction requires|nsubj|Stimulation Stimulation|nmod|expression expression|amod|END_ENTITY	Stimulation of tissue-type_plasminogen_activator expression by retinoic_acid in human endothelial cells requires retinoic_acid receptor beta 2 induction .
8695801	0	retinoic_acid	63,76	tissue-type_plasminogen_activator	15,48	retinoic acid	tissue-type plasminogen activator	MESH:D014212	5327	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Stimulation of tissue-type_plasminogen_activator expression by retinoic_acid in human endothelial cells requires retinoic_acid receptor beta 2 induction .
1323347	0	retinoic_acid	58,71	tissue_plasminogen_activator	15,43	retinoic acid	tissue plasminogen activator	MESH:D014212	100128998	Chemical	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	Stimulation of tissue_plasminogen_activator production by retinoic_acid : synergistic effect on protein_kinase_C-mediated activation .
1357767	0	retinoic_acid	54,67	tissue_transglutaminase	13,36	retinoic acid	tissue transglutaminase	MESH:D014212	21817(Tax:10090)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of tissue_transglutaminase and apoptosis by retinoic_acid in the limb bud .
7504461	0	retinoic_acid	64,77	tissue_transglutaminase	91,114	retinoic acid	tissue transglutaminase	MESH:D014212	21817(Tax:10090)	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Transformation of NIH3T3 cells with ras oncogenes abrogates the retinoic_acid induction of tissue_transglutaminase .
8626785	0	retinoic_acid	78,91	tissue_transglutaminase	169,192	retinoic acid	tissue transglutaminase	MESH:D014212	21817(Tax:10090)	Chemical	Gene	element|amod|START_ENTITY element|dep|element element|nmod|promoter promoter|compound|END_ENTITY	Identification and characterization of a versatile retinoid response element -LRB- retinoic_acid receptor response element-retinoid X receptor response element -RRB- in the mouse tissue_transglutaminase gene promoter .
8574976	0	retinoic_acid	10,23	transforming_growth_factor-beta	41,72	retinoic acid	transforming growth factor-beta	MESH:D014212	7040	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effect of retinoic_acid on expression of transforming_growth_factor-beta by retinal_pigment_epithelial cells in culture .
9641219	0	retinoic_acid	11,24	tumor_rejection_antigen	48,71	retinoic acid	tumor rejection antigen	MESH:D014212	55578	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effects of retinoic_acid on the expression of a tumor_rejection_antigen -LRB- heat_shock protein gp96 -RRB- in human cervical_cancer .
1350056	0	retinoic_acid	59,72	tyrosine_aminotransferase	14,39	retinoic acid	tyrosine aminotransferase	MESH:D014212	6898	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|expression expression|amod|END_ENTITY	Inhibition of tyrosine_aminotransferase gene expression by retinoic_acid .
19834471	0	retinoic_acid	86,99	uncoupling_protein-1	13,33	retinoic acid	uncoupling protein-1	MESH:D014212	22227(Tax:10090)	Chemical	Gene	adipocytes|nmod|START_ENTITY adipocytes|amod|END_ENTITY	Induction of uncoupling_protein-1 in mouse embryonic fibroblast-derived adipocytes by retinoic_acid .
9659286	0	retinoic_acid	24,37	uncoupling_protein-1	41,61	retinoic acid	uncoupling protein-1	MESH:D014212	24860(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|amod|END_ENTITY	Differential effects of retinoic_acid on uncoupling_protein-1 and leptin gene expression .
10567719	0	retinoic_acid	119,132	uncoupling_protein_3	17,37	retinoic acid	uncoupling protein 3	MESH:D014212	7352	Chemical	Gene	START_ENTITY|nsubj|Up-regulation Up-regulation|nmod|END_ENTITY	Up-regulation of uncoupling_protein_3 by thyroid hormone , peroxisome proliferator-activated receptor ligands and 9-cis retinoic_acid in L6 myotubes .
7529599	0	retinoic_acid	49,62	vitronectin	14,25	retinoic acid	vitronectin	MESH:D014212	7448	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Regulation of vitronectin receptor expression by retinoic_acid on human melanoma cells .
22562199	0	retinoic_acid	56,69	xCOUP-TF-B	0,10	retinoic acid	xCOUP-TF-B	MESH:D014212	380180(Tax:8355)	Chemical	Gene	regulates|ccomp|START_ENTITY regulates|nsubj|END_ENTITY	xCOUP-TF-B regulates xCyp26 transcription and modulates retinoic_acid signaling for anterior neural patterning in Xenopus .
7600972	0	retinoic_acid	29,42	xCRABP	60,66	retinoic acid	xCRABP	MESH:D014212	378522(Tax:8355)	Chemical	Gene	binding|amod|START_ENTITY protein|amod|binding protein|appos|END_ENTITY	Overexpression of a cellular retinoic_acid binding protein -LRB- xCRABP -RRB- causes anteroposterior defects in developing Xenopus embryos .
7877619	0	retinoic_acid	20,33	zif268	79,85	retinoic acid	zif268	MESH:D014212	24330(Tax:10116)	Chemical	Gene	sequences|amod|START_ENTITY sequences|acl:relcl|regulate regulate|dobj|expression expression|amod|END_ENTITY	Characterization of retinoic_acid - and cell-dependent sequences which regulate zif268 gene expression in osteoblastic cells .
26823704	0	retinoic_acid_amide	64,83	Akt	106,109	retinoic acid amide	Akt	null	207	Chemical	Gene	cell|nmod|START_ENTITY cell|nmod|activation activation|nmod|pathway pathway|compound|END_ENTITY	Inhibition of LN-308 glioma cell proliferation and migration by retinoic_acid_amide through activation of Akt pathway .
9174604	0	retinoic_acids	74,88	CD43	0,4	retinoic acids	CD43	null	6693	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	CD43 -LRB- leukosialin , sialophorin -RRB- expression is differentially regulated by retinoic_acids .
11836298	0	retinoic_acids	21,35	ERalpha	57,64	retinoic acids	ERalpha	null	2099	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Divergent effects of retinoic_acids on the expression of ERalpha and 17beta-hydroxysteroid_dehydrogenase_type_2 in endometrial_carcinoma cells -LRB- RL_95-2 -RRB- .
20724538	0	retinoic_acids	41,55	Olfactomedin_4	0,14	retinoic acids	Olfactomedin 4	null	10562	Chemical	Gene	gene|nmod|START_ENTITY gene|nsubj|END_ENTITY	Olfactomedin_4 is a novel target gene of retinoic_acids and 5-aza-2 ' - deoxycytidine involved in human myeloid_leukemia cell growth , differentiation , and apoptosis .
1545145	0	retinoic_acids	18,32	TGF-beta	158,166	retinoic acids	TGF-beta	null	21803(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of topical retinoic_acids on the levels of collagen mRNA during the repair of UVB-induced dermal_damage in the hairless mouse and the possible role of TGF-beta as a mediator .
7658149	0	retinoic_acids	99,113	apolipoprotein_A-I	20,38	retinoic acids	apolipoprotein A-I	null	335	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of human apolipoprotein_A-I expression in Caco-2 and HepG2 cells by all-trans and 9-cis retinoic_acids .
10681373	0	retinoic_acids	49,63	cytochrome_P-450	6,22	retinoic acids	cytochrome P-450	null	4051	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|amod|END_ENTITY	Human cytochrome_P-450 metabolism of retinals to retinoic_acids .
15306824	0	retinoic_acids	80,94	immediate_early_gene_X-1	18,42	retinoic acids	immediate early gene X-1	null	8870	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|expression expression|nmod|END_ENTITY	The expression of immediate_early_gene_X-1 -LRB- IEX-1 -RRB- is differentially induced by retinoic_acids in NB4 and KG1 cells : possible implication in the distinct phenotype of retinoic_acid-responsive and - resistant leukemic cells .
11274229	0	retinoic_acids	126,140	monocyte_chemoattractant_protein-1	69,103	retinoic acids	monocyte chemoattractant protein-1	null	24770(Tax:10116)	Chemical	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	Suppression of constitutive but not Il-1beta-inducible expression of monocyte_chemoattractant_protein-1 in mesangial cells by retinoic_acids : intervention in the activator_protein-1 pathway .
17510468	0	retinoid	34,42	CYP26	0,5	retinoid	CYP26	CHEBI:26537	1592	Chemical	Gene	START_ENTITY|nsubj|increases increases|compound|END_ENTITY	CYP26 inhibitor R115866 increases retinoid signaling in intimal smooth muscle cells .
24361262	0	retinoid	11,19	CYP26B1	30,37	retinoid	CYP26B1	CHEBI:26537	232174(Tax:10090)	Chemical	Gene	levels|amod|START_ENTITY levels|nmod|END_ENTITY	Control of retinoid levels by CYP26B1 is important for lymphatic vascular development in the mouse embryo .
8735598	0	retinoid	14,22	EGF	0,3	retinoid	EGF	CHEBI:26537	1950	Chemical	Gene	START_ENTITY|nsubj|increases increases|compound|END_ENTITY	EGF increases retinoid X receptor-alpha expression in human trophoblastic cells in culture : relationship with retinoic_acid induced human chorionic gonadotropin secretion .
11245924	9	retinoid	1662,1670	GnRH	1693,1697	retinoid	GnRH	CHEBI:26537	25194(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|nmod|expression expression|compound|END_ENTITY	To gain insights into the role of retinoid X receptors -LRB- RXRs -RRB- in GnRH expression , we examined the effects of RXR overexpression on GnRH transcriptional activity .
8590809	0	retinoid	20,28	Hsp90	11,16	retinoid	Hsp90	CHEBI:26537	855836(Tax:4932)	Chemical	Gene	receptor|amod|START_ENTITY END_ENTITY|nmod|receptor	A role for Hsp90 in retinoid receptor signal transduction .
17504753	0	retinoid	20,28	LRAT	8,12	retinoid	LRAT	CHEBI:26537	79235(Tax:10090)	Chemical	Gene	activity|amod|START_ENTITY Role|nmod|activity Role|nmod|END_ENTITY	Role of LRAT on the retinoid isomerase activity and membrane association of Rpe65 .
9516145	0	retinoid	15,23	MDR1	39,43	retinoid	MDR1	CHEBI:26537	5243	Chemical	Gene	sensitivity|amod|START_ENTITY sensitivity|nmod|END_ENTITY	Restoration of retinoid sensitivity by MDR1 ribozymes in retinoic_acid-resistant myeloid_leukemic cells .
9521860	0	retinoid	104,112	NF-kappa_B	128,138	retinoid	NF-kappa B	CHEBI:26537	4790	Chemical	Gene	receptors|amod|START_ENTITY receptors|nmod|END_ENTITY	TNF-alpha and 9-cis-retinoic_acid synergistically induce ICAM-1 expression : evidence for interaction of retinoid receptors with NF-kappa_B .
12576512	0	retinoid	49,57	RALDH1	18,24	retinoid	RALDH1	CHEBI:26537	24188(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY END_ENTITY|nmod|metabolism	Cloning of monkey RALDH1 and characterization of retinoid metabolism in monkey kidney proximal tubule cells .
8761883	0	retinoid	109,117	RAR_alpha	128,137	retinoid	RAR alpha	CHEBI:26537	19401(Tax:10090)	Chemical	Gene	receptors|amod|START_ENTITY END_ENTITY|dep|receptors	Pattern of retinoid-induced teratogenic effects : possible relationship with relative selectivity for nuclear retinoid receptors RAR_alpha , RAR_beta , and RAR_gamma .
11377877	0	retinoid	14,22	RARbeta	23,30	retinoid	RARbeta	CHEBI:26537	5915	Chemical	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	The levels of retinoid RARbeta receptors correlate with galectin-1 , _ -3 _ and _ -8 expression in human cholesteatomas .
11278635	0	retinoid	30,38	RIP140	178,184	retinoid	RIP140	CHEBI:26537	8204	Chemical	Gene	receptors|amod|START_ENTITY formation|nmod|receptors mediated|nsubjpass|formation mediated|nmod|motif motif|nmod|END_ENTITY	Ligand-dependent formation of retinoid receptors , receptor-interacting_protein_140 -LRB- RIP140 -RRB- , and histone deacetylase complex is mediated by a novel receptor-interacting motif of RIP140 .
11278635	0	retinoid	30,38	RIP140	84,90	retinoid	RIP140	CHEBI:26537	8204	Chemical	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Ligand-dependent formation of retinoid receptors , receptor-interacting_protein_140 -LRB- RIP140 -RRB- , and histone deacetylase complex is mediated by a novel receptor-interacting motif of RIP140 .
12403842	0	retinoid	47,55	RIP140	104,110	retinoid	RIP140	CHEBI:26537	8204	Chemical	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Real-time analysis of molecular interaction of retinoid receptors and receptor-interacting_protein_140 -LRB- RIP140 -RRB- .
12549917	0	retinoid	11,19	RIP140	31,37	retinoid	RIP140	CHEBI:26537	8204	Chemical	Gene	ligands|amod|START_ENTITY ligands|nmod|END_ENTITY	Effects of retinoid ligands on RIP140 : molecular interaction with retinoid receptors and biological activity .
12549917	0	retinoid	66,74	RIP140	31,37	retinoid	RIP140	CHEBI:26537	8204	Chemical	Gene	receptors|amod|START_ENTITY interaction|nmod|receptors Effects|dep|interaction Effects|nmod|ligands ligands|nmod|END_ENTITY	Effects of retinoid ligands on RIP140 : molecular interaction with retinoid receptors and biological activity .
14506269	1	retinoid	84,92	RIP140	106,112	retinoid	RIP140	CHEBI:26537	8204	Chemical	Gene	Self-limitation|nmod|START_ENTITY Self-limitation|acl|signaling signaling|nmod|END_ENTITY	Self-limitation of retinoid signaling by RIP140 .
19862326	0	retinoid	50,58	RIP140	112,118	retinoid	RIP140	CHEBI:26537	8204	Chemical	Gene	activity|amod|START_ENTITY oscillations|nmod|activity oscillations|dep|evidence evidence|nmod|role role|nmod|END_ENTITY	Retinoic_acid mediates long-paced oscillations in retinoid receptor activity : evidence for a potential role for RIP140 .
19862326	7	retinoid	908,916	RIP140	987,993	retinoid	RIP140	CHEBI:26537	8204	Chemical	Gene	START_ENTITY|ccomp|ablated ablated|nmod|overexpression overexpression|nmod|END_ENTITY	Cyclic retinoid receptor transactivation is ablated by constitutive overexpression of RIP140 .
21658367	0	retinoid	55,63	RXR-a	75,80	retinoid	RXR-a	CHEBI:26537	6256	Chemical	Gene	receptors|amod|START_ENTITY receptors|dep|END_ENTITY	Tissue factor dependent liver_injury causes release of retinoid receptors -LRB- RXR-a and RAR-a -RRB- as lipid droplets .
9543171	0	retinoid	82,90	RXR_alpha	69,78	retinoid	RXR alpha	CHEBI:26537	6256	Chemical	Gene	secretion|amod|START_ENTITY END_ENTITY|nmod|secretion	Retinoid receptors expression in human term placenta : involvement of RXR_alpha in retinoid induced-hCG secretion .
12750559	0	retinoid	36,44	RXRalpha	55,63	retinoid	RXRalpha	CHEBI:26537	6256	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Aberration in the expression of the retinoid receptor , RXRalpha , in prostate_cancer .
9694878	0	retinoid	38,46	RXRalpha	56,64	retinoid	RXRalpha	CHEBI:26537	6256	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Activation-induced down-regulation of retinoid receptor RXRalpha expression in human T lymphocytes .
17504753	0	retinoid	20,28	Rpe65	76,81	retinoid	Rpe65	CHEBI:26537	19892(Tax:10090)	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Role of LRAT on the retinoid isomerase activity and membrane association of Rpe65 .
12554754	1	retinoid	225,233	SMRT	265,269	retinoid	NCoR	CHEBI:26537	9611	Chemical	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	The thyroid hormone receptor -LRB- TR -RRB- recruits the nuclear corepressors , nuclear receptor corepressor -LRB- NCoR -RRB- and silencing mediator of retinoid and thyroid hormone receptors -LRB- SMRT -RRB- , to target DNA elements in the absence of ligand .
16219912	0	retinoid	100,108	SMRT	140,144	retinoid	SMRT	CHEBI:26537	9612	Chemical	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Regulation and binding of pregnane_X_receptor by nuclear receptor corepressor silencing mediator of retinoid and thyroid hormone receptors -LRB- SMRT -RRB- .
20371609	0	retinoid	26,34	SMRT	66,70	retinoid	SMRT	CHEBI:26537	20602(Tax:10090)	Chemical	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	The silencing mediator of retinoid and thyroid hormone receptors -LRB- SMRT -RRB- regulates adipose tissue accumulation and adipocyte_insulin_sensitivity in vivo .
15833882	0	retinoid	34,42	cyclooxygenase-2	68,84	retinoid	cyclooxygenase-2	CHEBI:26537	5743	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	The retinoid_X_receptor-selective retinoid , LGD1069 , down-regulates cyclooxygenase-2 expression in human breast cells through transcription factor crosstalk : implications for molecular-based chemoprevention .
8823154	0	retinoid	137,145	cytochrome_P450	103,118	retinoid	cytochrome P450	CHEBI:26537	4051	Chemical	Gene	control|nmod|START_ENTITY END_ENTITY|nmod|control	Involvement of alcohol_dehydrogenase , short-chain dehydrogenase/reductase , aldehyde dehydrogenase , and cytochrome_P450 in the control of retinoid signaling by activation of retinoic_acid synthesis .
19676051	0	retinoid	57,65	histone_deacetylase	80,99	retinoid	histone deacetylase	CHEBI:26537	9734	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|amod|END_ENTITY	Sensitization of ovarian_carcinoma cells to the atypical retinoid ST1926 by the histone_deacetylase inhibitor , RC307 : enhanced DNA damage response .
8626785	0	retinoid	51,59	tissue_transglutaminase	169,192	retinoid	tissue transglutaminase	CHEBI:26537	21817(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|element element|nmod|promoter promoter|compound|END_ENTITY	Identification and characterization of a versatile retinoid response element -LRB- retinoic_acid receptor response element-retinoid X receptor response element -RRB- in the mouse tissue_transglutaminase gene promoter .
11274407	0	retinoid	47,55	ultraspiracle	17,30	retinoid	ultraspiracle	CHEBI:26537	31165(Tax:7227)	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|appos|receptor	The dual role of ultraspiracle , the Drosophila retinoid X receptor , in the ecdysone response .
22077062	0	retinoid_Am80	10,23	Th1	89,92	retinoid Am80	Th1	null	57314(Tax:10090)	Chemical	Gene	ameliorates|nsubj|START_ENTITY ameliorates|nmod|END_ENTITY	Synthetic retinoid_Am80 ameliorates chronic graft-versus-host disease by down-regulating Th1 and Th17 .
23565190	0	retinoid_acid	20,33	NPSR1	111,116	retinoid acid	NPSR1	null	387129	Chemical	Gene	alpha|amod|START_ENTITY alpha|appos|END_ENTITY	Interaction between retinoid_acid receptor-related orphan receptor alpha -LRB- RORA -RRB- and neuropeptide_S_receptor_1 -LRB- NPSR1 -RRB- in asthma .
15058751	0	retinoid_acid	10,23	Notch1	34,40	retinoid acid	Notch1	null	4851	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	All-trans retinoid_acid increases Notch1 transcript expression in acute_promyelocytic_leukemia .
16441406	1	retinoid_acid	176,189	RAR-alpha	201,210	retinoid acid	RXR-alpha	null	6256	Chemical	Gene	receptors|amod|START_ENTITY receptors|dep|END_ENTITY	PURPOSE : The aim of this study is to investigate whether there are any abnormalities in the in vivo expression of retinoid_acid receptors -LRB- RAR-alpha , RAR-beta and RAR-gamma -RRB- and retinoid X receptors -LRB- RXR-alpha , RXR-beta and RXR-gamma -RRB- in sebaceous_cell_carcinoma .
23565190	0	retinoid_acid	20,33	RORA	74,78	retinoid acid	RORA	null	6095	Chemical	Gene	alpha|amod|START_ENTITY alpha|appos|END_ENTITY	Interaction between retinoid_acid receptor-related orphan receptor alpha -LRB- RORA -RRB- and neuropeptide_S_receptor_1 -LRB- NPSR1 -RRB- in asthma .
25079382	0	retinoids	14,23	ABCD2	60,65	retinoids	ABCD2	MESH:D012176	225	Chemical	Gene	Evaluation|nmod|START_ENTITY Evaluation|nmod|END_ENTITY	Evaluation of retinoids for induction of the redundant gene ABCD2 as an alternative treatment option in X-linked_adrenoleukodystrophy .
7969403	0	retinoids	15,24	AP-1	54,58	retinoids	AP-1	MESH:D012176	3726	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	A new class of retinoids with selective inhibition of AP-1 inhibits proliferation .
20426546	0	retinoids	15,24	CD38	47,51	retinoids	CD38	MESH:D012176	952	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Requirement of retinoids for the expression of CD38 on human hematopoietic progenitors in vitro .
8609714	0	retinoids	69,78	CD49f	0,5	retinoids	CD49f	MESH:D012176	3655	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	CD49f -LRB- alpha 6 integrin -RRB- and CD66a -LRB- BGP -RRB- are specifically induced by retinoids during human monocytic differentiation .
10882644	0	retinoids	53,62	CD95	14,18	retinoids	CD95	MESH:D012176	355	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|END_ENTITY	Modulation of CD95 in leukemia and lymphoma cells by retinoids .
15093674	0	retinoids	10,19	COX-2	35,40	retinoids	COX-2	MESH:D012176	17709(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effect of retinoids on LPS-induced COX-2 expression and COX-2 associated PGE -LRB- 2 -RRB- release from mouse peritoneal macrophages and TNF-alpha release from rat peripheral blood mononuclear cells .
11934446	0	retinoids	14,23	CRX	58,61	retinoids	CRX	MESH:D012176	1406	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|nmod|END_ENTITY	The effect of retinoids and butyrate on the expression of CRX and IRBP in retinoblastoma cells .
11302942	0	retinoids	30,39	CYP26	43,48	retinoids	CYP26	MESH:D012176	1592	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of receptor-selective retinoids on CYP26 gene expression and metabolism of all-trans-retinoic_acid in intestinal cells .
12445205	0	retinoids	65,74	Caspase-14	0,10	retinoids	Caspase-14	MESH:D012176	23581	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	Caspase-14 expression by epidermal keratinocytes is regulated by retinoids in a differentiation-associated manner .
7908827	0	retinoids	38,47	HOXD4	24,29	retinoids	HOXD4	MESH:D012176	3233	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|gene gene|compound|END_ENTITY	Regulation of the human HOXD4 gene by retinoids .
10921105	0	retinoids	25,34	IFN-gamma	55,64	retinoids	IFN-gamma	MESH:D012176	3458	Chemical	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	-LSB- Study on effects of new retinoids in combination with IFN-gamma on proliferation and differentiation of U937 cell and its mechanism -RSB- .
11233995	0	retinoids	14,23	IL-4	43,47	retinoids	IL-4	MESH:D012176	287287(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Inhibition by retinoids of antigen-induced IL-4 production in rat mast cell line RBL-2H3 .
8674128	1	retinoids	55,64	IL-4	138,142	retinoids	IL-4	MESH:D012176	16189(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY isotype|nsubj|role isotype|xcomp|switching switching|nmod|END_ENTITY	The role of retinoids in directing isotype switching to IgA and IgG1 -LRB- IgE -RRB- in association with IL-4 and IL-5 .
2857744	0	retinoids	32,41	Interferon-gamma	0,16	retinoids	Interferon-gamma	MESH:D012176	3458	Chemical	Gene	requires|dobj|START_ENTITY requires|nsubj|END_ENTITY	Interferon-gamma requires serum retinoids to promote the expression of tissue_transglutaminase in cultured human blood monocytes .
19121872	0	retinoids	56,65	LRAT	21,25	retinoids	LRAT	MESH:D012176	9227	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|appos|END_ENTITY	Retinoid metabolism -LRB- LRAT , REH -RRB- in the liver and plasma retinoids of bullfrog , Rana catesbeiana , in relation to agricultural contamination .
11856770	0	retinoids	67,76	Midkine	0,7	retinoids	Midkine	MESH:D012176	81517(Tax:10116)	Chemical	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	Midkine is involved in kidney development and in its regulation by retinoids .
19746216	0	retinoids	30,39	NF-kappaB	52,61	retinoids	NF-kappaB	MESH:D012176	4790	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	The chemopreventive effect of retinoids on cellular NF-kappaB activity induced by NMU and NEU in human malignant keratinocytes .
18404486	0	retinoids	34,43	P2Y2	16,20	retinoids	P2Y2	MESH:D012176	5029	Chemical	Gene	receptors|nmod|START_ENTITY receptors|nummod|END_ENTITY	Upregulation of P2Y2 receptors by retinoids in normal human epidermal keratinocytes .
10921005	0	retinoids	21,30	RAR_alpha	77,86	retinoids	RAR alpha	MESH:D012176	5914	Chemical	Gene	START_ENTITY|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Binding activity of retinoids with recombinant human retinoic_acid receptor RAR_alpha -RSB- .
7533656	1	retinoids	192,201	RAR_alpha	144,153	retinoids	RAR alpha	MESH:D012176	5914	Chemical	Gene	effect|nmod|START_ENTITY mediates|dobj|effect mediates|nsubj|END_ENTITY	RAR_alpha mediates the antiangiogenic effect of retinoids .
20456496	0	retinoids	78,87	RARalpha	116,124	retinoids	RARalpha	MESH:D012176	5914	Chemical	Gene	START_ENTITY|amod|binding binding|nmod|END_ENTITY	Keratins 2 and 4/13 in reconstituted human skin are reciprocally regulated by retinoids binding to nuclear receptor RARalpha .
21811588	0	retinoids	57,66	RIG-I	0,5	retinoids	RIG-I	MESH:D012176	23586	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	RIG-I is required for the inhibition of measles_virus by retinoids .
21060808	0	retinoids	63,72	RPTOR	35,40	retinoids	RPTOR	MESH:D012176	57521	Chemical	Gene	induced|nmod|START_ENTITY expression|acl|induced expression|amod|END_ENTITY	Allele-specific down-regulation of RPTOR expression induced by retinoids contributes to climate adaptations .
10441468	0	retinoids	59,68	Retinoic_acid_receptor_alpha	0,28	retinoids	Retinoic acid receptor alpha	MESH:D012176	5914	Chemical	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Retinoic_acid_receptor_alpha mediates growth inhibition by retinoids in human colon_carcinoma HT29 cells .
9823968	0	retinoids	59,68	Retinoic_acid_receptor_alpha	0,28	retinoids	Retinoic acid receptor alpha	MESH:D012176	24705(Tax:10116)	Chemical	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Retinoic_acid_receptor_alpha mediates growth inhibition by retinoids in rat pancreatic_carcinoma DSL-6A / C1 cells .
11675406	0	retinoids	11,20	TGF-beta	28,36	retinoids	TGF-beta	MESH:D012176	59086(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|system system|amod|END_ENTITY	Effects of retinoids on the TGF-beta system and extracellular matrix in experimental glomerulonephritis .
18974614	0	retinoids	10,19	UDP-glucuronosyltransferase_2B7	23,54	retinoids	UDP-glucuronosyltransferase 2B7	MESH:D012176	7364	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of retinoids on UDP-glucuronosyltransferase_2B7 mRNA expression in Caco-2 cells .
6201166	0	retinoids	15,24	alpha-fetoprotein	85,102	retinoids	alpha-fetoprotein	MESH:D012176	174	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of retinoids and bilirubin with the binding of arachidonic_acid to human alpha-fetoprotein .
2547418	0	retinoids	42,51	cellular_retinoic_acid_binding_protein	79,117	retinoids	cellular retinoic acid binding protein	MESH:D012176	1381	Chemical	Gene	START_ENTITY|nmod|modulation modulation|nmod|END_ENTITY	Isotretinoin differs from other synthetic retinoids in its modulation of human cellular_retinoic_acid_binding_protein -LRB- CRABP -RRB- .
1328400	0	retinoids	114,123	connexin_43	23,34	retinoids	connexin 43	MESH:D012176	2697	Chemical	Gene	modulation|nmod|START_ENTITY dermis|dep|modulation expressed|nmod|dermis expressed|nsubjpass|END_ENTITY	Gap-junctional protein connexin_43 is expressed in dermis and epidermis of human skin : differential modulation by retinoids .
15754312	0	retinoids	56,65	connexin_43	30,41	retinoids	connexin 43	MESH:D012176	2697	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Transcriptional regulation of connexin_43 expression by retinoids and carotenoids : similarities and differences .
25877907	0	retinoids	11,20	connexin_43	66,77	retinoids	connexin 43	MESH:D012176	2697	Chemical	Gene	role|nmod|START_ENTITY role|dep|regulation regulation|nmod|END_ENTITY	A role for retinoids in human oocyte fertilization : regulation of connexin_43 by retinoic_acid in cumulus granulosa cells .
7775379	0	retinoids	60,69	elastin	15,22	retinoids	elastin	MESH:D012176	396441(Tax:9031)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Modulations of elastin expression and cell proliferation by retinoids in cultured vascular smooth muscle cells .
9277454	0	retinoids	11,20	elastin	40,47	retinoids	elastin	MESH:D012176	25043(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|expression expression|amod|END_ENTITY	Endogenous retinoids increase perinatal elastin gene expression in rat lung fibroblasts and fetal explants .
12186877	0	retinoids	79,88	mitogen-activated_protein_kinase_phosphatase_1	29,75	retinoids	mitogen-activated protein kinase phosphatase 1	MESH:D012176	1843	Chemical	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	Transcriptional induction of mitogen-activated_protein_kinase_phosphatase_1 by retinoids .
3864525	0	retinoids	40,49	ornithine_decarboxylase	108,131	retinoids	ornithine decarboxylase	MESH:D012176	18263(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY Comparison|nmod|effects END_ENTITY|nsubj|Comparison	Comparison of the inhibitory effects of retinoids on 12-O-tetradecanoylphorbol-13-acetate-induced epidermal ornithine_decarboxylase activities in CD-1 and Sencar mice .
18280804	0	retinoids	93,102	p21	64,67	retinoids	p21	MESH:D012176	1026	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Role of the translational repressor 4E-BP1 in the regulation of p21 -LRB- Waf1/Cip1 -RRB- expression by retinoids .
8603404	0	retinoids	102,111	retinoic_acid_receptor-gamma	19,47	retinoids	retinoic acid receptor-gamma	MESH:D012176	5916	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Potential role for retinoic_acid_receptor-gamma in the inhibition of breast_cancer cells by selective retinoids and interferons .
10051583	0	retinoids	156,165	retinoic_acid_receptor_alpha	57,85	retinoids	retinoic acid receptor alpha	MESH:D012176	5914	Chemical	Gene	mimics|nmod|START_ENTITY heterodimers|acl:relcl|mimics heterodimers|dep|Ligand-dependent Ligand-dependent|advcl|vitro vitro|nmod|END_ENTITY	Ligand-dependent activation of transcription in vitro by retinoic_acid_receptor_alpha / retinoid_X_receptor_alpha heterodimers that mimics transactivation by retinoids in vivo .
2162635	0	retinoids	20,29	retinoic_acid_receptor_alpha	45,73	retinoids	retinoic acid receptor alpha	MESH:D012176	5914	Chemical	Gene	binding|nmod|START_ENTITY binding|nmod|END_ENTITY	In vitro binding of retinoids to the nuclear retinoic_acid_receptor_alpha .
8788040	0	retinoids	19,28	retinoic_acid_receptor_alpha	39,67	retinoids	retinoic acid receptor alpha	MESH:D012176	5914	Chemical	Gene	implicate|nsubj|START_ENTITY implicate|dobj|END_ENTITY	Receptor-selective retinoids implicate retinoic_acid_receptor_alpha and gamma in the regulation of bmp-2 and bmp-4 in F9 embryonal_carcinoma cells .
9823320	0	retinoids	93,102	retinoic_acid_receptor_alpha	120,148	retinoids	retinoic acid receptor alpha	MESH:D012176	5914	Chemical	Gene	response|nmod|START_ENTITY activates|dobj|response activates|nmod|expression expression|compound|END_ENTITY	Estrogen_receptor expression activates the transcriptional and growth-inhibitory response to retinoids without enhanced retinoic_acid_receptor_alpha expression .
17045963	0	retinoids	49,58	retinoid_X_receptor	71,90	retinoids	retinoid X receptor	MESH:D012176	6256	Chemical	Gene	induced|nmod|START_ENTITY induced|nmod|END_ENTITY	Expression of the human ABCC6 gene is induced by retinoids through the retinoid_X_receptor .
24265455	0	retinoids	104,113	steroidogenic_acute_regulatory_protein	26,64	retinoids	steroidogenic acute regulatory protein	MESH:D012176	20845(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Synergistic activation of steroidogenic_acute_regulatory_protein expression and steroid biosynthesis by retinoids : involvement of cAMP/PKA signaling .
1380592	0	retinoids	15,24	tissue-type_plasminogen_activator	28,61	retinoids	tissue-type plasminogen activator	MESH:D012176	5327	Chemical	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	Stimulation by retinoids of tissue-type_plasminogen_activator secretion in cultured human endothelial cells : relations of structure to effect .
1908141	0	retinoids	62,71	tissue-type_plasminogen_activator	15,48	retinoids	tissue-type plasminogen activator	MESH:D012176	5327	Chemical	Gene	Stimulation|nmod|START_ENTITY Stimulation|nmod|synthesis synthesis|amod|END_ENTITY	Stimulation of tissue-type_plasminogen_activator synthesis by retinoids in cultured human endothelial cells and rat tissues in vivo .
8498603	0	retinoids	51,60	tissue-type_plasminogen_activator	14,47	retinoids	tissue-type plasminogen activator	MESH:D012176	25692(Tax:10116)	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|END_ENTITY	Modulation of tissue-type_plasminogen_activator by retinoids in rat plasma and tissues .
2230595	0	retinoids	10,19	tumor_necrosis_factor-alpha	58,85	retinoids	tumor necrosis factor-alpha	MESH:D012176	7124	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effect of retinoids on the release and gene expression of tumor_necrosis_factor-alpha in human peripheral blood monocytes .
2826339	0	retinoids	11,20	tumor_necrosis_factor_alpha	93,120	retinoids	tumor necrosis factor alpha	MESH:D012176	7124	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of retinoids and interferon-gamma on cultured breast_cancer cells in comparison with tumor_necrosis_factor_alpha .
10473956	0	retinoids	22,31	vascular_endothelial_growth_factor	35,69	retinoids	vascular endothelial growth factor	MESH:D012176	7422	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Inhibitory effects of retinoids on vascular_endothelial_growth_factor production by cultured human skin keratinocytes .
10617662	0	retinoids	86,95	vascular_endothelial_growth_factor	14,48	retinoids	vascular endothelial growth factor	MESH:D012176	7422	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of vascular_endothelial_growth_factor expression in human keratinocytes by retinoids .
16054134	0	retinol	9,16	ARAT	34,38	retinol	ARAT	MESH:D014801	404129(Tax:9913)	Chemical	Gene	acyltransferase|amod|START_ENTITY acyltransferase|appos|END_ENTITY	Acyl_CoA : retinol acyltransferase -LRB- ARAT -RRB- activity is present in bovine retinal pigment epithelium .
3484732	6	retinol	1102,1109	CRBP	1052,1056	retinol	CRBP	MESH:D014801	5947	Chemical	Gene	concentration|amod|START_ENTITY concentration|dep|concentration concentration|compound|END_ENTITY	Tumour CRBP showed no correlation either to CRBP concentration in normal mucosa , or to plasma retinol or plasma retinol-binding_protein concentration .
1425454	0	retinol	202,209	EGF	173,176	retinol	EGF	MESH:D014801	408035(Tax:9031)	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Inhibition by epidermal_growth_factor -LRB- EGF -RRB- of epidermal DNA synthesis in cultured chick embryonic skin pretreated with retinol and/or hydrocortisone : specific increment in EGF binding activity in both retinol - and hydrocortisone-pretreated epidermis without correlation to EGF-mediated inhibition of cell growth .
9374503	0	retinol	11,18	IRBP	98,102	retinol	IRBP	MESH:D014801	5949	Chemical	Gene	Binding|nmod|START_ENTITY Binding|appos|END_ENTITY	Binding of retinol in both retinoid-binding sites of interphotoreceptor_retinoid-binding_protein -LRB- IRBP -RRB- is stabilized mainly by hydrophobic interactions .
17726077	0	retinol	47,54	Insulin	0,7	retinol	Insulin	MESH:D014801	3630	Chemical	Gene	binding|amod|START_ENTITY protein|amod|binding circulating|dobj|protein unrelated|advcl|circulating unrelated|nsubj|resistance resistance|compound|END_ENTITY	Insulin resistance is unrelated to circulating retinol binding protein and protein_C_inhibitor .
10386423	0	retinol	111,118	RBP	136,139	retinol	RBP	MESH:D014801	5950	Chemical	Gene	binding|amod|START_ENTITY protein|amod|binding protein|appos|END_ENTITY	The effect of ` renal-dose ' dopamine on renal tubular function following cardiac surgery : assessed by measuring retinol binding protein -LRB- RBP -RRB- .
20883645	0	retinol	31,38	RBP	25,28	retinol	RBP	MESH:D014801	281444(Tax:9913)	Chemical	Gene	START_ENTITY|nsubj|Retinol-binding_protein Retinol-binding_protein|appos|END_ENTITY	Retinol-binding_protein -LRB- RBP -RRB- , retinol and b-carotene in the bovine uterus and plasma during the oestrous cycle and the relationship between systemic progesterone and RBP on day 7 .
24803602	0	retinol	9,16	RBP	63,66	retinol	RBP	MESH:D014801	5950	Chemical	Gene	behaves|nsubj|START_ENTITY behaves|nmod|retinol retinol|nmod|END_ENTITY	How free retinol behaves differently from rbp-bound retinol in RBP receptor-mediated vitamin_A uptake .
24803603	0	retinol	19,26	RBP	73,76	retinol	RBP	MESH:D014801	5950	Chemical	Gene	behaves|nsubj|START_ENTITY behaves|nmod|retinol retinol|nmod|uptake uptake|compound|END_ENTITY	Reply to `` How free retinol behaves differently from RBP-bound retinol in RBP receptor-mediated vitamin_A uptake '' .
24803603	0	retinol	62,69	RBP	73,76	retinol	RBP	MESH:D014801	5950	Chemical	Gene	START_ENTITY|nmod|uptake uptake|compound|END_ENTITY	Reply to `` How free retinol behaves differently from RBP-bound retinol in RBP receptor-mediated vitamin_A uptake '' .
2739217	7	retinol	795,802	RBP	837,840	retinol	RBP	MESH:D014801	281444(Tax:9913)	Chemical	Gene	transported|nsubjpass|START_ENTITY transported|nmod|complex complex|nmod|END_ENTITY	These results suggested that , in cow , retinol was transported by the complex of RBP and another protein , presumably PA , but in calf , mainly by RBP alone .
3662139	0	retinol	31,38	RBP	58,61	retinol	RBP	MESH:D014801	5950	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	-LSB- Normal serum concentration of retinol transport protein -LRB- RBP -RRB- measured by an immunonephelometric method -RSB- .
575285	0	retinol	29,36	RBP	62,65	retinol	RBP	MESH:D014801	5950	Chemical	Gene	levels|nmod|START_ENTITY Decrease|nmod|levels Decrease|appos|END_ENTITY	-LSB- Decrease in serum levels of retinol and its binding protein -LRB- RBP -RRB- in infection -RSB- .
7531154	3	retinol	332,339	RBP	505,508	retinol	RBP	MESH:D014801	5950	Chemical	Gene	order|nsubj|START_ENTITY order|nmod|magnitude magnitude|amod|efficient efficient|advcl|blocking blocking|advcl|administered administered|nmod|complex complex|nmod|END_ENTITY	We show here that retinol is at least an order of magnitude more efficient at blocking the terminal differentiation of cultured normal human keratinocytes when administered as a complex with RBP than when administered free in solution .
9260907	0	retinol	87,94	RBP	65,68	retinol	RBP	MESH:D014801	25703(Tax:10116)	Chemical	Gene	uptake|nmod|START_ENTITY Interactions|nmod|uptake Interactions|nmod|transthyretin transthyretin|appos|END_ENTITY	Interactions of transthyretin -LRB- TTR -RRB- and retinol-binding_protein -LRB- RBP -RRB- in the uptake of retinol by primary rat hepatocytes .
9260907	1	retinol	160,167	RBP	198,201	retinol	TTR	MESH:D014801	24856(Tax:10116)	Chemical	Gene	take|dobj|START_ENTITY take|dep|END_ENTITY	The mechanism by which cells take up retinol from retinol-binding_protein -LRB- RBP -RRB- and the role of the RBP-transthyretin -LRB- TTR -RRB- complex remain unclear .
7531154	0	retinol	43,50	Retinol-binding_protein	0,23	retinol	Retinol-binding protein	MESH:D014801	5950	Chemical	Gene	uptake|nmod|START_ENTITY uptake|nsubj|mediates mediates|amod|END_ENTITY	Retinol-binding_protein mediates uptake of retinol to cultured human keratinocytes .
25073702	0	retinol	21,28	Serum_amyloid_A	0,15	retinol	Serum amyloid A	MESH:D014801	111345(Tax:10090)	Chemical	Gene	protein|amod|START_ENTITY protein|nsubj|END_ENTITY	Serum_amyloid_A is a retinol binding protein that transports retinol during bacterial_infection .
9260907	0	retinol	87,94	TTR	31,34	retinol	TTR	MESH:D014801	24856(Tax:10116)	Chemical	Gene	uptake|nmod|START_ENTITY Interactions|nmod|uptake Interactions|nmod|transthyretin transthyretin|appos|END_ENTITY	Interactions of transthyretin -LRB- TTR -RRB- and retinol-binding_protein -LRB- RBP -RRB- in the uptake of retinol by primary rat hepatocytes .
18492757	0	retinol	12,19	adiponectin	53,64	retinol	adiponectin	MESH:D014801	9370	Chemical	Gene	concentrations|compound|START_ENTITY concentrations|compound|END_ENTITY	High plasma retinol binding protein-4 and low plasma adiponectin concentrations are associated with severity of glucose_intolerance in women with previous_gestational_diabetes_mellitus .
11928954	0	retinol	39,46	beta-lactoglobulin	10,28	retinol	beta-lactoglobulin	MESH:D014801	280838(Tax:9913)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of beta-lactoglobulin on plasma retinol and triglyceride concentrations , and fatty_acid composition in calves .
3015290	0	retinol	18,25	cRABP	70,75	retinol	cRABP	MESH:D014801	1381	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	-LSB- Presence of free retinol receptor -LRB- cRBP -RRB- and retinoic_acid receptor -LRB- cRABP -RRB- in human skin_tumors -RSB- .
3015290	0	retinol	18,25	cRBP	36,40	retinol	cRBP	MESH:D014801	5947	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	-LSB- Presence of free retinol receptor -LRB- cRBP -RRB- and retinoic_acid receptor -LRB- cRABP -RRB- in human skin_tumors -RSB- .
1622339	0	retinol	110,117	epidermal_growth_factor	78,101	retinol	epidermal growth factor	MESH:D014801	13645(Tax:10090)	Chemical	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	Alteration of murine odontogenic patterning and prolongation of expression of epidermal_growth_factor mRNA by retinol in vitro .
18430770	0	retinol	6,13	insulin	46,53	retinol	insulin	MESH:D014801	3630	Chemical	Gene	protein|amod|START_ENTITY related|nsubjpass|protein related|nmod|resistance resistance|compound|END_ENTITY	Serum retinol binding protein 4 is related to insulin resistance and nonoxidative glucose metabolism in lean and obese women with normal glucose tolerance .
9374503	0	retinol	11,18	interphotoreceptor_retinoid-binding_protein	53,96	retinol	interphotoreceptor retinoid-binding protein	MESH:D014801	5949	Chemical	Gene	START_ENTITY|nmod|sites sites|nmod|END_ENTITY	Binding of retinol in both retinoid-binding sites of interphotoreceptor_retinoid-binding_protein -LRB- IRBP -RRB- is stabilized mainly by hydrophobic interactions .
23136757	0	retinol	11,18	period1	49,56	retinol	period1	MESH:D014801	287422(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of retinol on interaction of the protein period1 , oxytocin , and GABA at the prenatal period of formation of the circadian clock-mechanism in rats -RSB- .
4101	0	retinol	14,21	phospholipase_a	58,73	retinol	phospholipase a	MESH:D014801	288025(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|compound|END_ENTITY	The effect of retinol and retinoic_acid on the testicular phospholipase_a activity in retinol-deficient rats .
15967793	0	retinol	14,21	rdh1l	37,42	retinol	rdh1l	MESH:D014801	322529(Tax:7955)	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	The zebrafish retinol dehydrogenase , rdh1l , is essential for intestinal development and is regulated by the tumor suppressor adenomatous_polyposis_coli .
10457350	0	retinol	93,100	retinol-binding_protein	46,69	retinol	retinol-binding protein	MESH:D014801	19662(Tax:10090)	Chemical	Gene	regulated|nmod|START_ENTITY secretion|acl|regulated secretion|amod|END_ENTITY	MMH cells : An in vitro model for the study of retinol-binding_protein secretion regulated by retinol .
12787682	0	retinol	70,77	retinol-binding_protein	30,53	retinol	retinol-binding protein	MESH:D014801	281444(Tax:9913)	Chemical	Gene	complex|nmod|START_ENTITY END_ENTITY|nmod|complex	High-resolution structures of retinol-binding_protein in complex with retinol : pH-induced protein structural changes in the crystal state .
1445851	0	retinol	16,23	retinol-binding_protein	60,83	retinol	retinol-binding protein	MESH:D014801	5950	Chemical	Gene	Interactions|nmod|START_ENTITY Interactions|dep|studies studies|nmod|END_ENTITY	Interactions of retinol with binding proteins : studies with retinol-binding_protein and with transthyretin .
14587034	0	retinol	33,40	retinol-binding_protein	57,80	retinol	retinol-binding protein	MESH:D014801	5950	Chemical	Gene	START_ENTITY|acl|associated associated|nmod|END_ENTITY	Hepatic stellate cells uptake of retinol associated with retinol-binding_protein or with bovine serum albumin .
17867372	0	retinol	104,111	retinol-binding_protein	42,65	retinol	retinol-binding protein	MESH:D014801	5950	Chemical	Gene	uptake|nmod|START_ENTITY Identification|nmod|uptake Identification|nmod|receptor receptor|nmod|functioning functioning|amod|END_ENTITY	Identification of a membrane receptor for retinol-binding_protein functioning in the cellular uptake of retinol .
18410697	0	retinol	94,101	retinol-binding_protein	21,44	retinol	retinol-binding protein	MESH:D014801	5950	Chemical	Gene	concentrations|amod|START_ENTITY estimate|dobj|concentrations using|advcl|estimate using|dobj|END_ENTITY	Feasibility of using retinol-binding_protein from capillary blood specimens to estimate serum retinol concentrations and the prevalence of vitamin_A_deficiency in low-resource settings .
2611252	0	retinol	19,26	retinol-binding_protein	51,74	retinol	retinol-binding protein	MESH:D014801	5950	Chemical	Gene	accumulation|amod|START_ENTITY Characteristics|nmod|accumulation Characteristics|nmod|END_ENTITY	Characteristics of retinol accumulation from serum retinol-binding_protein by cultured Sertoli cells .
26672737	0	retinol	97,104	retinol-binding_protein	63,86	retinol	retinol-binding protein	MESH:D014801	25703(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY transport|amod|END_ENTITY	Antenatal retinoic_acid administration increases trophoblastic retinol-binding_protein dependent retinol transport in the nitrofen model of congenital_diaphragmatic_hernia .
3368453	0	retinol	12,19	retinol-binding_protein	79,102	retinol	retinol-binding protein	MESH:D014801	25703(Tax:10116)	Chemical	Gene	Transfer|nmod|START_ENTITY mediated|nsubjpass|Transfer mediated|nmod|END_ENTITY	Transfer of retinol from parenchymal to stellate cells in liver is mediated by retinol-binding_protein .
6774741	0	retinol	146,153	retinol-binding_protein	21,44	retinol	retinol-binding protein	MESH:D014801	5950	Chemical	Gene	malnourished|nmod|START_ENTITY malnourished|nsubj|changes changes|nmod|concentrations concentrations|compound|END_ENTITY	The early changes in retinol-binding_protein and prealbumin concentrations in plasma of protein-energy malnourished children after treatment with retinol and an improved diet .
7200983	0	retinol	10,17	retinol-binding_protein	28,51	retinol	retinol-binding protein	MESH:D014801	25703(Tax:10116)	Chemical	Gene	status|amod|START_ENTITY status|nmod|END_ENTITY	Effect of retinol status on retinol-binding_protein biosynthesis rate and translatable messenger RNA level in rat liver .
8375617	0	retinol	85,92	retinol-binding_protein	37,60	retinol	retinol-binding protein	MESH:D014801	25703(Tax:10116)	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Retinoids : in vitro interaction with retinol-binding_protein and influence on plasma retinol .
8425602	0	retinol	35,42	retinol-binding_protein	48,71	retinol	retinol-binding protein	MESH:D014801	5950	Chemical	Gene	Mechanism|nmod|START_ENTITY Mechanism|nmod|END_ENTITY	Mechanism of pH-induced release of retinol from retinol-binding_protein .
9710574	0	retinol	11,18	retinol-binding_protein	59,82	retinol	retinol-binding protein	MESH:D014801	5950	Chemical	Gene	Release|nmod|START_ENTITY Release|nmod|carrier carrier|appos|END_ENTITY	Release of retinol and denaturation of its plasma carrier , retinol-binding_protein .
9772136	0	retinol	21,28	transthyretin	48,61	retinol	transthyretin	MESH:D014801	24856(Tax:10116)	Chemical	Gene	protein|amod|START_ENTITY protein|nmod|END_ENTITY	A low molar ratio of retinol binding protein to transthyretin indicates vitamin_A_deficiency during inflammation : studies in rats and a posterior analysis of vitamin_A-supplemented children with measles .
27089473	0	retinyl_acetate	10,25	transglutaminase_2	29,47	retinyl acetate	transglutaminase 2	MESH:C009166	56083(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effect of retinyl_acetate on transglutaminase_2 activity in carcinogen treated rat liver .
8206972	0	retinyl_ester	33,46	Lipoprotein_lipase	0,18	retinyl ester	Lipoprotein lipase	CHEBI:16179	100340171(Tax:9986)	Chemical	Gene	hydrolysis|nmod|START_ENTITY hydrolysis|amod|END_ENTITY	Lipoprotein_lipase hydrolysis of retinyl_ester .
14532273	0	retinyl_ester	11,24	Rpe65	0,5	retinyl ester	Rpe65	CHEBI:16179	19892(Tax:10090)	Chemical	Gene	protein|compound|START_ENTITY protein|nsubj|END_ENTITY	Rpe65 is a retinyl_ester binding protein that presents insoluble substrate to the isomerase in retinal pigment epithelial cells .
10769148	0	retinyl_esters	14,28	pancreatic_triglyceride_lipase	32,62	retinyl esters	pancreatic triglyceride lipase	CHEBI:16179	69060(Tax:10090)	Chemical	Gene	Hydrolysis|nmod|START_ENTITY Hydrolysis|nmod|END_ENTITY	Hydrolysis of retinyl_esters by pancreatic_triglyceride_lipase .
17719606	0	retinylidene	21,33	rhodopsin	44,53	retinylidene	rhodopsin	null	6010	Chemical	Gene	ligand|amod|START_ENTITY ligand|nmod|END_ENTITY	Dynamic structure of retinylidene ligand of rhodopsin probed by molecular simulations .
1282584	0	retrothiorphan	58,72	neutral_endopeptidase	25,46	retrothiorphan	neutral endopeptidase	MESH:C072559	24590(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Effects of the selective neutral_endopeptidase inhibitor , retrothiorphan , on renal function and blood pressure in conscious normotensive Wistar and hypertensive DOCA-salt rats .
9414127	0	retrotransposon	53,68	intracisternal_A-particle	70,95	retrotransposon	intracisternal A-particle	null	15601(Tax:10090)	Chemical	Gene	element|compound|START_ENTITY element|amod|END_ENTITY	Detection and cloning of unique integration sites of retrotransposon , intracisternal_A-particle element in the genome of acute_myeloid_leukemia cells in mice .
21533487	0	rhIL-11	31,38	interleukin-11	15,29	rhIL-11	interleukin-11	MESH:C105308	3589	Chemical	Gene	Interaction|dep|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of interleukin-11 -LRB- rhIL-11 -RRB- with cytotoxic therapies in the human HT-29 colon_carcinoma .
8611685	0	rhIL-11	61,68	interleukin-11	37,51	rhIL-11	interleukin-11	MESH:C105308	3589	Chemical	Gene	factor|compound|START_ENTITY END_ENTITY|appos|factor	A phase I trial of recombinant human interleukin-11 -LRB- neumega rhIL-11 growth factor -RRB- in women with breast_cancer receiving chemotherapy .
17490774	0	rhIL11	71,77	interleukin-11	55,69	rhIL11	interleukin-11	MESH:C105308	3589	Chemical	Gene	activity|appos|START_ENTITY activity|nmod|END_ENTITY	Enhanced pharmacological activity of recombinant human interleukin-11 -LRB- rhIL11 -RRB- by chemical modification with polyethylene_glycol .
11259321	0	rhapontigenin	59,72	cytochrome_P450_1A1	36,55	rhapontigenin	cytochrome P450 1A1	MESH:C431126	1543	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Mechanism-based inhibition of human cytochrome_P450_1A1 by rhapontigenin .
25821307	0	rhein	59,64	Toll-like_receptor_4	0,20	rhein	Toll-like receptor 4	MESH:C020491	29260(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY involved|nmod|effect involved|nsubjpass|END_ENTITY	Toll-like_receptor_4 is involved in a protective effect of rhein on immunoglobulin A nephropathy .
20621639	0	rhodamine-123	87,100	ATPase	109,115	rhodamine-123	ATPase	CHEBI:8828	1769	Chemical	Gene	activity|amod|START_ENTITY activity|dep|END_ENTITY	Differences in assessment of macrolide interaction with human MDR1 -LRB- ABCB1 , P-gp -RRB- using rhodamine-123 efflux , ATPase activity and cellular accumulation assays .
10086998	0	rhodamine_123	13,26	P-glycoprotein	30,44	rhodamine 123	P-glycoprotein	CHEBI:8828	287115(Tax:10116)	Chemical	Gene	START_ENTITY|appos|substrate substrate|amod|END_ENTITY	Transport of rhodamine_123 , a P-glycoprotein substrate , across rat intestine and Caco-2 cell monolayers in the presence of cytochrome P-450 3A-related compounds .
10342379	0	rhodamine_123	42,55	P-glycoprotein	8,22	rhodamine 123	P-glycoprotein	CHEBI:8828	100008914(Tax:9986)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of P-glycoprotein in distribution of rhodamine_123 into aqueous_humor in rabbits .
11159804	0	rhodamine_123	73,86	P-glycoprotein	90,104	rhodamine 123	P-glycoprotein	CHEBI:8828	287115(Tax:10116)	Chemical	Gene	START_ENTITY|appos|substrate substrate|amod|END_ENTITY	Pharmacokinetic interaction of cytochrome P450 3A-related compounds with rhodamine_123 , a P-glycoprotein substrate , in rats pretreated with dexamethasone .
2576349	0	rhodamine_123	80,93	P-glycoprotein	45,59	rhodamine 123	P-glycoprotein	CHEBI:8828	5243	Chemical	Gene	correlation|nmod|START_ENTITY correlation|nmod|END_ENTITY	Reciprocal correlation between expression of P-glycoprotein and accumulation of rhodamine_123 in human tumors .
16530413	0	rhodanine	39,48	PRL-3	64,69	rhodanine	PRL-3	MESH:D012236	11156	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Synthesis and biological evaluation of rhodanine derivatives as PRL-3 inhibitors .
23352746	0	rhynchophylline	35,50	NMDAR1	82,88	rhynchophylline	NMDAR1	MESH:C052714	24408(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|compound|END_ENTITY	Individual and combined effects of rhynchophylline and ketamine on proliferation , NMDAR1 and GluA2/3 protein expression in PC12 cells .
25193707	0	rhynchophylline	10,25	NR2B	75,79	rhynchophylline	NR2B	MESH:C052714	14812(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|preference preference|nmod|expression expression|nmod|END_ENTITY	Effect of rhynchophylline on conditioned place preference on expression of NR2B in methamphetamine-dependent mice .
25011570	0	ribavirin	33,42	CNT1	16,20	ribavirin	CNT1	MESH:D012254	9154	Chemical	Gene	Contribution|nmod|START_ENTITY Contribution|nmod|END_ENTITY	Contribution of CNT1 and ENT1 to ribavirin uptake in human hepatocytes .
19164463	0	ribavirin	93,102	ENT1	56,60	ribavirin	ENT1	MESH:D012254	2030	Chemical	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of the equilibrative_nucleoside_transporter_1 -LRB- ENT1 -RRB- in transport and metabolism of ribavirin by human and wild-type or Ent1 - / - mouse erythrocytes .
22232287	0	ribavirin	77,86	ENT1	0,4	ribavirin	ENT1	MESH:D012254	2030	Chemical	Gene	efficacy|nmod|START_ENTITY role|nmod|efficacy plays|dobj|role plays|nsubj|END_ENTITY	ENT1 , a ribavirin transporter , plays a pivotal role in antiviral efficacy of ribavirin in a hepatitis_C_virus replication cell system .
22232287	0	ribavirin	8,17	ENT1	0,4	ribavirin	ENT1	MESH:D012254	2030	Chemical	Gene	transporter|amod|START_ENTITY END_ENTITY|appos|transporter	ENT1 , a ribavirin transporter , plays a pivotal role in antiviral efficacy of ribavirin in a hepatitis_C_virus replication cell system .
12971972	0	ribavirin	58,67	IFN-alpha	34,43	ribavirin	IFN-alpha	MESH:D012254	3439	Chemical	Gene	combined|nmod|START_ENTITY combined|nsubj|trial trial|nmod|END_ENTITY	Randomized , controlled trial with IFN-alpha combined with ribavirin with and without amantadine_sulphate in non-responders with chronic hepatitis_C .
23439262	0	ribavirin	111,120	IL28B	124,129	ribavirin	IL28B	MESH:D012254	282617	Chemical	Gene	START_ENTITY|nmod|patients patients|compound|END_ENTITY	A phase 2a trial of 12-week interferon-free therapy with two direct-acting antivirals -LRB- ABT-450 / r , ABT-072 -RRB- and ribavirin in IL28B C/C patients with chronic hepatitis_C genotype 1 .
12606760	0	ribavirin	41,50	NDP_kinase	62,72	ribavirin	NDP kinase	MESH:D012254	129607	Chemical	Gene	analogs|amod|START_ENTITY analogs|nmod|END_ENTITY	Structural analysis of the activation of ribavirin analogs by NDP_kinase : comparison with other ribavirin targets .
17845853	0	ribavirin	19,28	S-adenosyl-L-homocysteine_hydrolase	57,92	ribavirin	S-adenosyl-L-homocysteine hydrolase	MESH:D012254	191	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	The antiviral drug ribavirin is a selective inhibitor of S-adenosyl-L-homocysteine_hydrolase from Trypanosoma_cruzi .
16699498	0	ribavirin	27,36	TGF-beta1	61,70	ribavirin	TGF-beta1	MESH:D012254	7040	Chemical	Gene	treatment|compound|START_ENTITY Effects|nmod|treatment Effects|nmod|END_ENTITY	Effects of interferon plus ribavirin treatment on NF-kappaB , TGF-beta1 , and metalloproteinase activity in chronic hepatitis_C .
16377237	0	ribavirin	20,29	Th1	0,3	ribavirin	Th1	MESH:D012254	51497	Chemical	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Th1 response during ribavirin and interferon-alpha combination therapy in chronic hepatitis_C .
20483710	0	ribavirin	158,167	Th1	10,13	ribavirin	Th1	MESH:D012254	51497	Chemical	Gene	interferon|nmod|START_ENTITY down-regulated|nmod|interferon down-regulated|nsubjpass|responses responses|compound|Th17 Th17|compound|END_ENTITY	Increased Th1 , Th17 and pro-fibrotic responses in hepatitis_C-infected patients are down-regulated after 12 weeks of treatment with pegylated interferon plus ribavirin .
24442435	0	ribavirin	146,155	Th1	115,118	ribavirin	Th1	MESH:D012254	57314(Tax:10090)	Chemical	Gene	therapy|compound|START_ENTITY reversible|nmod|therapy shift|amod|reversible induces|nmod|shift induces|dobj|END_ENTITY	Cleavage of the T cell protein tyrosine phosphatase by the hepatitis_C virus nonstructural 3/4A protease induces a Th1 to Th2 shift reversible by ribavirin therapy .
16251386	0	ribavirin	22,31	eIF4E	47,52	ribavirin	eIF4E	MESH:D012254	1977	Chemical	Gene	evidence|acl:relcl|START_ENTITY interacts|nsubj|evidence interacts|nmod|END_ENTITY	Further evidence that ribavirin interacts with eIF4E .
19433856	0	ribavirin	116,125	eIF4E	36,41	ribavirin	eIF4E	MESH:D012254	1977	Chemical	Gene	trial|nmod|START_ENTITY targeting|dep|trial targeting|nmod|END_ENTITY	Molecular targeting of the oncogene eIF4E in acute_myeloid_leukemia -LRB- AML -RRB- : a proof-of-principle clinical trial with ribavirin .
25425688	0	ribavirin	19,28	eIF4E	135,140	ribavirin	eIF4E	MESH:D012254	1977	Chemical	Gene	trial|nmod|START_ENTITY I|dobj|trial I|nmod|END_ENTITY	A phase I trial of ribavirin and low-dose cytarabine for the treatment of relapsed and refractory acute myeloid_leukemia with elevated eIF4E .
19164463	0	ribavirin	93,102	equilibrative_nucleoside_transporter_1	16,54	ribavirin	equilibrative nucleoside transporter 1	MESH:D012254	2030	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of the equilibrative_nucleoside_transporter_1 -LRB- ENT1 -RRB- in transport and metabolism of ribavirin by human and wild-type or Ent1 - / - mouse erythrocytes .
21346780	0	ribavirin	108,117	interferon-a	90,102	ribavirin	interferon-a	MESH:D012254	3440	Chemical	Gene	therapy|compound|START_ENTITY therapy|compound|END_ENTITY	IL28B genetic variations are associated with high sustained virological response -LRB- SVR -RRB- of interferon-a plus ribavirin therapy in Taiwanese chronic_HCV_infection .
14633177	0	ribavirin	82,91	interferon-alpha2b	58,76	ribavirin	interferon-alpha2b	MESH:D012254	3440	Chemical	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	Comparative study of the efficacy of an induction dose of interferon-alpha2b with ribavirin compared with standard combined treatment in naive patients with chronic hepatitis_C .
16149143	0	ribavirin	67,76	interferon-alpha2b	10,28	ribavirin	interferon-alpha2b	MESH:D012254	3440	Chemical	Gene	therapy|nmod|START_ENTITY therapy|amod|END_ENTITY	High-dose interferon-alpha2b induction therapy in combination with ribavirin for treatment of chronic hepatitis_C in patients with non-response or relapse after interferon-alpha monotherapy .
17441805	0	ribavirin	83,92	interferon-alpha2b	59,77	ribavirin	interferon-alpha2b	MESH:D012254	3440	Chemical	Gene	therapy|compound|START_ENTITY therapy|compound|END_ENTITY	Diabetes_mellitus reduces the therapeutic effectiveness of interferon-alpha2b plus ribavirin therapy in patients with chronic hepatitis_C .
18610555	0	ribavirin	98,107	interferon-alpha2b	51,69	ribavirin	interferon-alpha2b	MESH:D012254	3440	Chemical	Gene	combination|nmod|START_ENTITY combination|amod|END_ENTITY	Combinations of 2 ' - C-methylcytidine analogues with interferon-alpha2b and triple combination with ribavirin in the hepatitis_C virus replicon system .
21161001	0	ribavirin	36,45	interferon-b	52,64	ribavirin	interferon-b	MESH:D012254	3456	Chemical	Gene	START_ENTITY|nmod|induction induction|amod|END_ENTITY	Twenty four-week peginterferon plus ribavirin after interferon-b induction for genotype 1b chronic hepatitis_C .
11211891	0	ribavirin	55,64	interferon_alpha-2b	15,34	ribavirin	interferon alpha-2b	MESH:D012254	3440	Chemical	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	The effects of interferon_alpha-2b in combination with ribavirin on health related quality of life and work productivity .
16761995	0	ribavirin	61,70	interferon_alpha-2b	21,40	ribavirin	interferon alpha-2b	MESH:D012254	3440	Chemical	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	Twenty-four weeks of interferon_alpha-2b in combination with ribavirin for Japanese hepatitis_C patients : sufficient treatment period for patients with genotype 2 but not for patients with genotype 1 .
15902734	0	ribavirin	87,96	interferon_alpha_2b	62,81	ribavirin	interferon alpha 2b	MESH:D012254	3440	Chemical	Gene	therapy|compound|START_ENTITY END_ENTITY|nmod|therapy	Expression of bcl-2 protein in chronic hepatitis_C : effect of interferon_alpha_2b with ribavirin therapy .
19277449	0	ribavirin	95,104	interferon_alpha_2b	70,89	ribavirin	interferon alpha 2b	MESH:D012254	3440	Chemical	Gene	prediction|nmod|START_ENTITY prediction|nmod|END_ENTITY	Effective prediction of outcome of combination therapy with pegylated interferon_alpha_2b plus ribavirin in Japanese patients with genotype-1 chronic hepatitis_C using early viral kinetics and new indices .
16425392	0	ribavirin	45,54	transforming_growth_factor-beta1	75,107	ribavirin	transforming growth factor-beta1	MESH:D012254	7040	Chemical	Gene	treatment|amod|START_ENTITY treatment|amod|END_ENTITY	Effect of pegylated interferon_alpha_2b plus ribavirin treatment on plasma transforming_growth_factor-beta1 , metalloproteinase-1 , and tissue metalloproteinase inhibitor-1 in patients with chronic hepatitis_C .
23583375	0	ribavirin_triphosphate	121,143	eIF4E	79,84	ribavirin triphosphate	eIF4E	null	1977	Chemical	Gene	induced|advmod|START_ENTITY induced|nmod|END_ENTITY	Conformational changes induced in the eukaryotic translation initiation factor eIF4E by a clinically relevant inhibitor , ribavirin_triphosphate .
23275236	0	riboflavin	48,58	C20orf54	72,80	riboflavin	C20orf54	MESH:D012256	113278	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association of the plasma riboflavin levels and riboflavin transporter -LRB- C20orf54 -RRB- gene statuses in Kazak esophageal_squamous_cell_carcinoma patients .
9458829	0	riboflavin	28,38	HK-2	98,102	riboflavin	HK-2	MESH:D012256	3099	Chemical	Gene	Mechanism|nmod|START_ENTITY uptake|nsubj|Mechanism uptake|nmod|END_ENTITY	Mechanism and regulation of riboflavin uptake by human renal proximal tubule epithelial cell line HK-2 .
25284511	0	riboflavin	71,81	SLC52A1	102,109	riboflavin	SLC52A1	MESH:D012256	55065	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Identification and characterization of 5 ' - flanking region of the human riboflavin transporter 1 gene -LRB- SLC52A1 -RRB- .
237845	0	riboflavin	60,70	glutathione_reductase	20,41	riboflavin	glutathione reductase	MESH:D012256	2936	Chemical	Gene	status|compound|START_ENTITY END_ENTITY|nmod|status	Flavin_nucleotides , glutathione_reductase and assessment of riboflavin status .
21554614	0	ribonucleic_Acid	87,103	luteinizing_hormone-releasing_hormone	27,64	ribonucleic Acid	luteinizing hormone-releasing hormone	CHEBI:33697	25194(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|messenger messenger|compound|END_ENTITY	Differential regulation of luteinizing_hormone-releasing_hormone and galanin messenger ribonucleic_Acid levels by alpha -LRB- 1 -RRB- adrenergic agents in the ovariectomized rat .
21554648	0	ribonucleic_Acid	74,90	proopiomelanocortin	44,63	ribonucleic Acid	proopiomelanocortin	CHEBI:33697	24664(Tax:10116)	Chemical	Gene	messenger|acl|START_ENTITY messenger|compound|END_ENTITY	Oestrogen positive feedback reduces arcuate proopiomelanocortin messenger ribonucleic_Acid .
21554656	0	ribonucleic_Acid	130,146	tyrosine_hydroxylase	38,58	ribonucleic Acid	tyrosine hydroxylase	CHEBI:33697	25085(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	Repeated immobilization stress alters tyrosine_hydroxylase , corticotropin-releasing_hormone and corticosteroid receptor messenger ribonucleic_Acid levels in rat brain .
2522772	0	ribonucleic_acid	36,52	Atrial_natriuretic_factor	0,25	ribonucleic acid	Atrial natriuretic factor	CHEBI:33697	4878	Chemical	Gene	START_ENTITY|nsubj|messenger messenger|compound|END_ENTITY	Atrial_natriuretic_factor messenger ribonucleic_acid and peptide in the human heart during ontogenic development .
9464858	0	ribonucleic_acid	41,57	Basic_fibroblast_growth_factor	0,30	ribonucleic acid	Basic fibroblast growth factor	CHEBI:33697	2247	Chemical	Gene	START_ENTITY|nsubj|messenger messenger|compound|END_ENTITY	Basic_fibroblast_growth_factor messenger ribonucleic_acid levels in human placentas from normal and pathological pregnancies .
6093800	0	ribonucleic_acid	86,102	Corticotropin-releasing_factor	0,30	ribonucleic acid	Corticotropin-releasing factor	CHEBI:33697	81648(Tax:10116)	Chemical	Gene	regulates|ccomp|START_ENTITY regulates|nsubj|END_ENTITY	Corticotropin-releasing_factor differentially regulates proopiomelanocortin messenger ribonucleic_acid levels in anterior as compared to intermediate pituitary lobes of rats .
6332279	0	ribonucleic_acid	71,87	Corticotropin-releasing_factor	0,30	ribonucleic acid	Corticotropin-releasing factor	CHEBI:33697	81648(Tax:10116)	Chemical	Gene	regulates|ccomp|START_ENTITY regulates|nsubj|END_ENTITY	Corticotropin-releasing_factor regulates proopiomelanocortin messenger ribonucleic_acid levels in vivo .
26273355	0	ribonucleic_acid	50,66	FOXN1	88,93	ribonucleic acid	FOXN1	D012313	8456	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	In vitro study of the effect of small interfering ribonucleic_acid on the expression of FOXN1 and B_cell-attracting_chemokine_1 in thymoma cell lines .
8275955	0	ribonucleic_acid	68,84	FSH_receptor	45,57	ribonucleic acid	FSH receptor	CHEBI:33697	2492	Chemical	Gene	START_ENTITY|nsubj|messenger messenger|compound|END_ENTITY	Follicle-stimulating hormone -LRB- FSH -RRB- increases FSH_receptor messenger ribonucleic_acid while decreasing FSH binding in cultured porcine granulosa cells .
8119173	0	ribonucleic_acid	108,124	GAP-43	76,82	ribonucleic acid	GAP-43	CHEBI:33697	29423(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|messenger messenger|compound|END_ENTITY	Estrogen and androgen differentially modulate the growth-associated protein GAP-43 -LRB- neuromodulin -RRB- messenger ribonucleic_acid in postnatal rat brain .
10830294	0	ribonucleic_acid	96,112	GH	28,30	ribonucleic acid	GH	CHEBI:33697	81668(Tax:10116)	Chemical	Gene	levels|amod|START_ENTITY expression|nmod|levels inhibit|dobj|expression inhibit|nsubj|levels levels|appos|END_ENTITY	High plasma growth_hormone -LRB- GH -RRB- levels inhibit expression of GH secretagogue receptor messenger ribonucleic_acid levels in the rat pituitary .
10830294	0	ribonucleic_acid	96,112	GH	61,63	ribonucleic acid	GH	CHEBI:33697	81668(Tax:10116)	Chemical	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	High plasma growth_hormone -LRB- GH -RRB- levels inhibit expression of GH secretagogue receptor messenger ribonucleic_acid levels in the rat pituitary .
2004472	0	ribonucleic_acid	55,71	GH	41,43	ribonucleic acid	GH	CHEBI:33697	2688	Chemical	Gene	START_ENTITY|nsubj|relationship relationship|nmod|messenger messenger|appos|END_ENTITY	The relationship between growth_hormone -LRB- GH -RRB- messenger ribonucleic_acid levels and hormone release from individual cells derived from human GH-secreting pituitary_adenomas .
2152867	0	ribonucleic_acid	131,147	GH	118,120	ribonucleic acid	GH	CHEBI:33697	81668(Tax:10116)	Chemical	Gene	messenger|acl|START_ENTITY messenger|compound|END_ENTITY	Molecular mechanism of growth_hormone -LRB- GH -RRB- deficiency in the spontaneous dwarf rat : detection of abnormal splicing of GH messenger ribonucleic_acid by the polymerase chain reaction .
2152867	0	ribonucleic_acid	131,147	GH	39,41	ribonucleic acid	GH	CHEBI:33697	81668(Tax:10116)	Chemical	Gene	messenger|acl|START_ENTITY splicing|nmod|messenger detection|nmod|splicing mechanism|dep|detection mechanism|nmod|deficiency deficiency|appos|END_ENTITY	Molecular mechanism of growth_hormone -LRB- GH -RRB- deficiency in the spontaneous dwarf rat : detection of abnormal splicing of GH messenger ribonucleic_acid by the polymerase chain reaction .
2307109	0	ribonucleic_acid	153,169	GH	70,72	ribonucleic acid	GH	CHEBI:33697	2688	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|feeding feeding|appos|END_ENTITY	Effect of restricted feeding on the concentrations of growth_hormone -LRB- GH -RRB- , gonadotropins , and prolactin -LRB- PRL -RRB- in plasma , and on the amounts of messenger ribonucleic_acid for GH , gonadotropin subunits , and PRL in the pituitary glands of adult ovariectomized ewes .
2731486	0	ribonucleic_acid	40,56	GH	27,29	ribonucleic acid	GH	CHEBI:33697	81668(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|concentration concentration|nmod|messenger messenger|compound|END_ENTITY	Pituitary concentration of GH messenger ribonucleic_acid in rats with anterolateral hypothalamic deafferentation .
2737142	0	ribonucleic_acid	116,132	GH	103,105	ribonucleic acid	GH	CHEBI:33697	81668(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|messenger messenger|compound|END_ENTITY	Heat shock of cultured GC cells enhances the level of triiodothyronine induced growth_hormone -LRB- GH -RRB- and GH messenger ribonucleic_acid .
10022420	0	ribonucleic_acid	64,80	GHRH	48,52	ribonucleic acid	GHRH	CHEBI:33697	2691	Chemical	Gene	_|amod|START_ENTITY _|appos|END_ENTITY	Expression of growth_hormone-releasing_hormone -LRB- GHRH -RRB- messenger ribonucleic_acid and the presence of biologically active GHRH in human breast , _ endometrial , _ and_ovarian_cancers .
8732461	0	ribonucleic_acid	134,150	GnRH_receptor	110,123	ribonucleic acid	GnRH receptor	CHEBI:33697	81668(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|messenger messenger|compound|END_ENTITY	Continuous stimulation of gonadotropin-releasing_hormone -LRB- GnRH -RRB- receptors by GnRH agonist decreases pituitary GnRH_receptor messenger ribonucleic_acid concentration in immature female rats .
9166707	0	ribonucleic_acid	119,135	GnRH_receptor	140,153	ribonucleic acid	GnRH receptor	CHEBI:33697	281798(Tax:9913)	Chemical	Gene	START_ENTITY|nmod|subunits subunits|compound|END_ENTITY	Effects of bovine follicular fluid and passive immunization against gonadotropin-releasing_hormone -LRB- GnRH -RRB- on messenger ribonucleic_acid for GnRH_receptor and gonadotropin subunits in ovariectomized ewes .
2117526	0	ribonucleic_acid	43,59	Growth_hormone-releasing_hormone	0,32	ribonucleic acid	Growth hormone-releasing hormone	CHEBI:33697	29446(Tax:10116)	Chemical	Gene	messenger|acl|START_ENTITY messenger|amod|END_ENTITY	Growth_hormone-releasing_hormone messenger ribonucleic_acid in the hypothalamus of the adult male rat is increased by testosterone .
10919271	0	ribonucleic_acid	103,119	IGF-I	59,64	ribonucleic acid	IGF-I	CHEBI:33697	24482(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|appos|END_ENTITY	Effect of growth hormone and insulin-like_growth_factor_I -LRB- IGF-I -RRB- on the expression of IGF-I messenger ribonucleic_acid and peptide in rat tibial growth plate and articular chondrocytes in vivo .
8855838	0	ribonucleic_acid	128,144	IGFBP-5	110,117	ribonucleic acid	IGFBP-5	CHEBI:33697	3488	Chemical	Gene	messenger|acl|START_ENTITY messenger|compound|END_ENTITY	Insulin-like growth factor-binding proteins -LRB- IGFBP -RRB- -4 , -5 , and -6 in the benign and malignant human prostate : IGFBP-5 messenger ribonucleic_acid localization differs from IGFBP-5 protein localization .
8855838	0	ribonucleic_acid	128,144	IGFBP-5	171,178	ribonucleic acid	IGFBP-5	CHEBI:33697	3488	Chemical	Gene	START_ENTITY|nmod|localization localization|compound|END_ENTITY	Insulin-like growth factor-binding proteins -LRB- IGFBP -RRB- -4 , -5 , and -6 in the benign and malignant human prostate : IGFBP-5 messenger ribonucleic_acid localization differs from IGFBP-5 protein localization .
9024273	0	ribonucleic_acid	47,63	IL-13	20,25	ribonucleic acid	IL-13	CHEBI:33697	3596	Chemical	Gene	START_ENTITY|nsubj|Detection Detection|nmod|END_ENTITY	Detection of IL-12 , IL-13 , and IL-15 messenger ribonucleic_acid in the thyroid of patients with autoimmune_thyroid_disease .
8568239	0	ribonucleic_acid	46,62	IL-5	22,26	ribonucleic acid	IL-5	CHEBI:33697	3567	Chemical	Gene	START_ENTITY|nsubj|messenger messenger|compound|END_ENTITY	Human B cells express IL-5 receptor messenger ribonucleic_acid and respond to IL-5 with enhanced IgM production after mitogenic stimulation with Moraxella_catarrhalis .
1639013	0	ribonucleic_acid	32,48	Insulin	0,7	ribonucleic acid	Insulin	CHEBI:33697	3630	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|compound|END_ENTITY	Insulin regulation of messenger ribonucleic_acid for the surfactant-associated proteins in human fetal lung in vitro .
9607779	0	ribonucleic_acid	106,122	LHRH	91,95	ribonucleic acid	LHRH	CHEBI:33697	14714(Tax:10090)	Chemical	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Luteinizing_hormone_releasing_hormone -LRB- LHRH -RRB- neurons maintained in nasal explants decrease LHRH messenger ribonucleic_acid levels after activation of GABA -LRB- A -RRB- receptors .
1407661	0	ribonucleic_acid	25,41	Neuropeptide_Y	0,14	ribonucleic acid	Neuropeptide Y	CHEBI:33697	24604(Tax:10116)	Chemical	Gene	messenger|acl|START_ENTITY messenger|amod|END_ENTITY	Neuropeptide_Y messenger ribonucleic_acid in the magnocellular hypothalamo-neurohypophysial system of the rat is increased during osmotic stimulation .
11159869	0	ribonucleic_acid	23,39	Pleiotrophin	0,12	ribonucleic acid	Pleiotrophin	CHEBI:33697	19242(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|messenger messenger|compound|END_ENTITY	Pleiotrophin messenger ribonucleic_acid levels increase in mouse endometrial stromal cells during decidualization .
7720632	0	ribonucleic_acid	32,48	Progesterone_receptor	0,21	ribonucleic acid	Progesterone receptor	CHEBI:33697	613024(Tax:9544)	Chemical	Gene	messenger|acl|START_ENTITY messenger|amod|END_ENTITY	Progesterone_receptor messenger ribonucleic_acid in the primate corpus luteum during the menstrual cycle : possible regulation by progesterone .
1391339	0	ribonucleic_acid	101,117	Prolactin	0,9	ribonucleic acid	Prolactin	CHEBI:33697	24683(Tax:10116)	Chemical	Gene	messenger|acl|START_ENTITY luteinizing|dobj|messenger expression|acl|luteinizing stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Prolactin stimulates the expression of luteinizing hormone/chorionic gonadotropin receptor messenger ribonucleic_acid in the rat corpus luteum and rescues early pregnancy from bromocriptine-induced abortion .
2002749	0	ribonucleic_acid	20,36	Prolactin	0,9	ribonucleic acid	Prolactin	CHEBI:33697	443317(Tax:9940)	Chemical	Gene	START_ENTITY|nsubj|messenger messenger|compound|END_ENTITY	Prolactin messenger ribonucleic_acid concentrations throughout the ovine estrous cycle : assessment relative to prolactin serum and pituitary amounts .
2329917	0	ribonucleic_acid	20,36	Prolactin	0,9	ribonucleic acid	Prolactin	CHEBI:33697	101843376	Chemical	Gene	START_ENTITY|nsubj|messenger messenger|compound|END_ENTITY	Prolactin messenger ribonucleic_acid levels , prolactin synthesis , and radioimmunoassayable prolactin during the estrous cycle in the golden Syrian_hamster .
2924734	0	ribonucleic_acid	20,36	Prolactin	0,9	ribonucleic acid	Prolactin	CHEBI:33697	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|messenger messenger|compound|END_ENTITY	Prolactin messenger ribonucleic_acid concentrations in 4-day cycling rats and during the prolactin surge .
3096690	0	ribonucleic_acid	20,36	Prolactin	0,9	ribonucleic acid	Prolactin	CHEBI:33697	19109(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|messenger messenger|compound|END_ENTITY	Prolactin messenger ribonucleic_acid levels in the normal and hypogonadal mouse pituitary gland .
8212993	0	ribonucleic_acid	60,76	Proopiomelanocortin	0,19	ribonucleic acid	Proopiomelanocortin	CHEBI:33697	443212(Tax:9940)	Chemical	Gene	START_ENTITY|nsubj|messenger messenger|compound|END_ENTITY	Proopiomelanocortin , prolactin and growth_hormone messenger ribonucleic_acid levels in the fetal sheep pituitary during late gestation .
9864065	0	ribonucleic_acid	46,62	Somatostatin	0,12	ribonucleic acid	Somatostatin	CHEBI:33697	24797(Tax:10116)	Chemical	Gene	decreases|ccomp|START_ENTITY decreases|nsubj|END_ENTITY	Somatostatin decreases somatostatin messenger ribonucleic_acid levels in the rat periventricular nucleus .
17118994	0	ribonucleic_acid	47,63	Thyroid-stimulating_hormone_receptor	0,36	ribonucleic acid	Thyroid-stimulating hormone receptor	CHEBI:33697	7253	Chemical	Gene	START_ENTITY|nsubj|messenger messenger|compound|END_ENTITY	Thyroid-stimulating_hormone_receptor messenger ribonucleic_acid measurement in blood as a marker for circulating thyroid_cancer cells and its role in the preoperative diagnosis of thyroid_cancer .
9348202	0	ribonucleic_acid	107,123	VEGF	72,76	ribonucleic acid	VEGF	CHEBI:33697	7422	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|END_ENTITY	Differential hormonal regulation of vascular_endothelial_growth_factors VEGF , VEGF-B , and VEGF-C messenger ribonucleic_acid levels in cultured human granulosa-luteal cells .
3569140	0	ribonucleic_acid	22,38	Vasopressin	0,11	ribonucleic acid	Vasopressin	CHEBI:33697	551	Chemical	Gene	messenger|acl|START_ENTITY messenger|compound|END_ENTITY	Vasopressin messenger ribonucleic_acid in supraoptic and suprachiasmatic nuclei : appearance and circadian regulation during development .
18583425	0	ribonucleic_acid	47,63	agouti-related_protein	14,36	ribonucleic acid	agouti-related protein	CHEBI:33697	181	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|messenger messenger|amod|END_ENTITY	Regulation of agouti-related_protein messenger ribonucleic_acid transcription and peptide secretion by acute_and_chronic_inflammation .
2441975	0	ribonucleic_acid	65,81	alpha_2u-globulin	29,46	ribonucleic acid	alpha 2u-globulin	CHEBI:33697	298111(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|synthesis synthesis|nmod|END_ENTITY	Sex-independent synthesis of alpha_2u-globulin and its messenger ribonucleic_acid in the rat preputial gland : biochemical and immunocytochemical analyses .
2968239	0	ribonucleic_acid	70,86	atrial_natriuretic_factor	14,39	ribonucleic acid	atrial natriuretic factor	CHEBI:33697	24602(Tax:10116)	Chemical	Gene	levels|amod|START_ENTITY Modulation|dep|levels Modulation|nmod|END_ENTITY	Modulation of atrial_natriuretic_factor by thyroid hormone : messenger ribonucleic_acid and peptide levels in hypothyroid , euthyroid , and hyperthyroid rat atria and ventricles .
8238204	0	ribonucleic_acid	93,109	atrial_natriuretic_factor	25,50	ribonucleic acid	atrial natriuretic factor	CHEBI:33697	100294648(Tax:9940)	Chemical	Gene	START_ENTITY|nsubj|changes changes|nmod|content content|compound|END_ENTITY	Developmental changes in atrial_natriuretic_factor content and localization of its messenger ribonucleic_acid in ovine fetal heart .
7590624	0	ribonucleic_acid	85,101	basic_fibroblast_growth_factor	36,66	ribonucleic acid	basic fibroblast growth factor	CHEBI:33697	54250(Tax:10116)	Chemical	Gene	messenger|acl|START_ENTITY Fasting|dep|messenger Fasting|dep|increases increases|dobj|expression expression|nmod|END_ENTITY	Fasting increases the expression of basic_fibroblast_growth_factor -LRB- FGF-2 -RRB- messenger ribonucleic_acid in rat hypothalamus .
10218987	0	ribonucleic_acid	104,120	c-fos	88,93	ribonucleic acid	c-fos	CHEBI:33697	314322(Tax:10116)	Chemical	Gene	messenger|acl|START_ENTITY messenger|amod|END_ENTITY	Centrally administered adrenomedullin increases plasma oxytocin level with induction of c-fos messenger ribonucleic_acid in the paraventricular and supraoptic nuclei of the rat .
12399428	0	ribonucleic_acid	94,110	c-fos	78,83	ribonucleic acid	c-fos	CHEBI:33697	314322(Tax:10116)	Chemical	Gene	messenger|acl|START_ENTITY messenger|amod|END_ENTITY	Centrally administered neuromedin_U activates neurosecretion and induction of c-fos messenger ribonucleic_acid in the paraventricular and supraoptic nuclei of rat .
3125035	0	ribonucleic_acid	101,117	c-fos	75,80	ribonucleic acid	c-fos	CHEBI:33697	2353	Chemical	Gene	messenger|acl|START_ENTITY messenger|amod|END_ENTITY	Epidermal_growth_factor , but not thyrotropin , stimulates the expression of c-fos and c-myc messenger ribonucleic_acid in porcine thyroid follicle cells in primary culture .
2484717	0	ribonucleic_acid	39,55	c-myc	23,28	ribonucleic acid	c-myc	CHEBI:33697	24577(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|messenger messenger|amod|END_ENTITY	Androgen regulation of c-myc messenger ribonucleic_acid levels in rat ventral prostate .
3036482	0	ribonucleic_acid	85,101	c-myc	69,74	ribonucleic acid	c-myc	CHEBI:33697	4609	Chemical	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	A growth stimulatory effect of iodide is suggested by its effects on c-myc messenger ribonucleic_acid levels , -LSB- 3H -RSB- thymidine incorporation , and mitotic activity of porcine follicle cells in suspension culture .
7921218	0	ribonucleic_acid	45,61	c-myc	29,34	ribonucleic acid	c-myc	CHEBI:33697	4609	Chemical	Gene	START_ENTITY|nsubj|expression expression|nmod|messenger messenger|amod|END_ENTITY	Stage-specific expression of c-myc messenger ribonucleic_acid in porcine granulosa cells early in follicular growth .
8828833	0	ribonucleic_acid	138,154	cLH-R	122,127	ribonucleic acid	cLH-R	CHEBI:33697	395776(Tax:9031)	Chemical	Gene	START_ENTITY|nsubj|expression expression|nmod|messenger messenger|amod|END_ENTITY	Characterization of a chicken luteinizing hormone receptor -LRB- cLH-R -RRB- complementary deoxyribonucleic_acid , and expression of cLH-R messenger ribonucleic_acid in the ovary .
2347900	0	ribonucleic_acid	39,55	chromogranin-A	14,28	ribonucleic acid	chromogranin-A	CHEBI:33697	1113	Chemical	Gene	START_ENTITY|nsubj|Expression Expression|nmod|messenger messenger|amod|END_ENTITY	Expression of chromogranin-A messenger ribonucleic_acid in parathyroid tissue from patients with primary_hyperparathyroidism .
1935773	0	ribonucleic_acid	77,93	chromogranin_A	52,66	ribonucleic acid	chromogranin A	CHEBI:33697	24258(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Estradiol negatively regulates secretogranin_II and chromogranin_A messenger ribonucleic_acid levels in the female rat pituitary but not in the adrenal .
9165053	0	ribonucleic_acid	47,63	chromogranin_A	22,36	ribonucleic acid	chromogranin A	CHEBI:33697	24258(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|messenger messenger|compound|END_ENTITY	In vivo regulation of chromogranin_A messenger ribonucleic_acid in the parathyroid by 1,25-dihydroxyvitamin _ D : studies in normal rats and in chronic_renal_insufficiency .
8142549	0	ribonucleic_acid	49,65	connexin_43	14,25	ribonucleic acid	connexin 43	CHEBI:33697	24392(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Expression Expression|nmod|messenger messenger|amod|END_ENTITY	Expression of connexin_43 gap junction messenger ribonucleic_acid and protein during follicular atresia .
7916682	0	ribonucleic_acid	87,103	corticosteroid-binding_globulin	37,68	ribonucleic acid	corticosteroid-binding globulin	CHEBI:33697	12401(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|distribution distribution|nmod|END_ENTITY	Spatial and temporal distribution of corticosteroid-binding_globulin and its messenger ribonucleic_acid in embryonic and fetal mice .
1850346	0	ribonucleic_acid	70,86	corticotropin-releasing_factor	29,59	ribonucleic acid	corticotropin-releasing factor	CHEBI:33697	81648(Tax:10116)	Chemical	Gene	level|compound|START_ENTITY level|amod|END_ENTITY	Angiotensin_II increases the corticotropin-releasing_factor messenger ribonucleic_acid level in the rat hypothalamus .
8392133	0	ribonucleic_acid	70,86	corticotropin-releasing_factor	29,59	ribonucleic acid	corticotropin-releasing factor	CHEBI:33697	81648(Tax:10116)	Chemical	Gene	level|compound|START_ENTITY level|amod|END_ENTITY	Neuropeptide_Y increases the corticotropin-releasing_factor messenger ribonucleic_acid level in the rat hypothalamus .
10218971	0	ribonucleic_acid	111,127	corticotropin-releasing_hormone	44,75	ribonucleic acid	corticotropin-releasing hormone	CHEBI:33697	702877(Tax:9544)	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|estrogen estrogen|nmod|messenger messenger|compound|END_ENTITY	The effects of estrogen and progesterone on corticotropin-releasing_hormone and arginine_vasopressin messenger ribonucleic_acid levels in the paraventricular nucleus and supraoptic nucleus of the rhesus_monkey .
2171915	0	ribonucleic_acid	87,103	corticotropin-releasing_hormone	20,51	ribonucleic acid	corticotropin-releasing hormone	CHEBI:33697	81648(Tax:10116)	Chemical	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Regulation of basal corticotropin-releasing_hormone and arginine_vasopressin messenger ribonucleic_acid expression in the paraventricular nucleus : effects of selective hypothalamic deafferentations .
8119200	0	ribonucleic_acid	81,97	corticotropin-releasing_hormone	39,70	ribonucleic acid	corticotropin-releasing hormone	CHEBI:33697	81648(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|messenger messenger|amod|END_ENTITY	Thyroid hormone-mediated regulation of corticotropin-releasing_hormone messenger ribonucleic_acid in the rat .
17127751	0	ribonucleic_acid	75,91	cytochrome_P450_aromatase	39,64	ribonucleic acid	cytochrome P450 aromatase	CHEBI:33697	281740(Tax:9913)	Chemical	Gene	messenger|acl|START_ENTITY messenger|amod|END_ENTITY	Control of oestradiol secretion and of cytochrome_P450_aromatase messenger ribonucleic_acid accumulation by FSH involves different intracellular pathways in oestrogenic bovine granulosa cells in vitro .
7769365	0	ribonucleic_acid	79,95	endothelin-1	56,68	ribonucleic acid	endothelin-1	CHEBI:33697	24323(Tax:10116)	Chemical	Gene	messenger|amod|START_ENTITY messenger|amod|END_ENTITY	Developmental expression and anatomical localization of endothelin-1 messenger ribonucleic_acid and immunoreactivity in the rat placenta : a northern analysis and immunohistochemistry study .
8917275	1	ribonucleic_acid	183,199	endothelin-1	160,172	ribonucleic acid	endothelin-1	CHEBI:33697	24323(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|expression expression|nmod|messenger messenger|amod|END_ENTITY	Increased expression of endothelin-1 messenger ribonucleic_acid and endothelin-1-like immunoreactivity in the lung in congestive_heart_failure in rats .
3263984	0	ribonucleic_acid	62,78	epidermal_growth_factor_receptor	11,43	ribonucleic acid	epidermal growth factor receptor	CHEBI:33697	1956	Chemical	Gene	START_ENTITY|nsubj|Changes Changes|nmod|END_ENTITY	Changes in epidermal_growth_factor_receptor and its messenger ribonucleic_acid levels in human placenta and isolated trophoblast cells during pregnancy .
2282976	0	ribonucleic_acid	50,66	estrogen_receptor	14,31	ribonucleic acid	estrogen receptor	CHEBI:33697	2099	Chemical	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of estrogen_receptor and its messenger ribonucleic_acid in the MCF-7 cell line : multiparametric analysis of its processing and regulation by estrogen .
7678235	0	ribonucleic_acid	41,57	estrogen_receptor	13,30	ribonucleic acid	estrogen receptor	CHEBI:33697	2099	Chemical	Gene	START_ENTITY|nsubj|Detection Detection|nmod|messenger messenger|compound|END_ENTITY	Detection of estrogen_receptor messenger ribonucleic_acid in human oocytes and cumulus-oocyte complexes using reverse transcriptase-polymerase chain reaction .
8288720	0	ribonucleic_acid	59,75	estrogen_receptor	31,48	ribonucleic acid	estrogen receptor	CHEBI:33697	2099	Chemical	Gene	START_ENTITY|nsubj|study study|nmod|messenger messenger|compound|END_ENTITY	In situ hybridization study of estrogen_receptor messenger ribonucleic_acid in human adenohypophysial cells and pituitary_adenomas .
9348186	0	ribonucleic_acid	129,145	estrogen_receptor-alpha	49,72	ribonucleic acid	estrogen receptor-alpha	CHEBI:33697	13982(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|distribution distribution|nmod|END_ENTITY	Tissue distribution and quantitative analysis of estrogen_receptor-alpha -LRB- ERalpha -RRB- and estrogen_receptor-beta -LRB- ERbeta -RRB- messenger ribonucleic_acid in the wild-type and ERalpha-knockout mouse .
1311235	0	ribonucleic_acid	71,87	follicle-stimulating_hormone_receptor	23,60	ribonucleic acid	follicle-stimulating hormone receptor	CHEBI:33697	25449(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|messenger messenger|amod|END_ENTITY	Hormonal regulation of follicle-stimulating_hormone_receptor messenger ribonucleic_acid levels in cultured rat granulosa cells .
7758841	0	ribonucleic_acid	62,78	follicle-stimulating_hormone_receptor	14,51	ribonucleic acid	follicle-stimulating hormone receptor	CHEBI:33697	25449(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|messenger messenger|amod|END_ENTITY	Regulation of follicle-stimulating_hormone_receptor messenger ribonucleic_acid levels in cultured rat granulosa cells .
1855461	0	ribonucleic_acid	40,56	follistatin	18,29	ribonucleic acid	follistatin	CHEBI:33697	24373(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|changes changes|nmod|messenger messenger|compound|END_ENTITY	Cyclic changes in follistatin messenger ribonucleic_acid and its protein in the rat ovary during the estrous cycle .
7664979	0	ribonucleic_acid	36,52	follistatin	14,25	ribonucleic acid	follistatin	CHEBI:33697	24373(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|messenger messenger|compound|END_ENTITY	Regulation of follistatin messenger ribonucleic_acid in cultured rat granulosa cells .
8462462	0	ribonucleic_acid	36,52	follistatin	14,25	ribonucleic acid	follistatin	CHEBI:33697	10468	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|messenger messenger|compound|END_ENTITY	Regulation of follistatin messenger ribonucleic_acid in porcine granulosa cells by epidermal_growth_factor and the protein_kinase-C pathway .
9492023	0	ribonucleic_acid	66,82	galanin	48,55	ribonucleic acid	galanin	CHEBI:33697	29141(Tax:10116)	Chemical	Gene	messenger|acl|START_ENTITY messenger|compound|END_ENTITY	Expression of functional estrogen receptors and galanin messenger ribonucleic_acid in immortalized luteinizing hormone-releasing hormone neurons : estrogenic control of galanin gene expression .
12959995	0	ribonucleic_acid	58,74	ghrelin	40,47	ribonucleic acid	ghrelin	CHEBI:33697	59301(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|distribution distribution|nmod|messenger messenger|compound|END_ENTITY	Cellular distribution and regulation of ghrelin messenger ribonucleic_acid in the rat pituitary gland .
12574199	0	ribonucleic_acid	168,184	gonadotropin_releasing_hormone	26,56	ribonucleic acid	gonadotropin releasing hormone	CHEBI:33697	2796	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|END_ENTITY	Dose-dependent effects of gonadotropin_releasing_hormone on matrix_metalloproteinase _ -LRB- MMP -RRB- -2 , and MMP-9 and tissue specific inhibitor of metalloproteinases-1 messenger ribonucleic_acid levels in human decidual Stromal cells in vitro .
12108784	0	ribonucleic_acid	45,61	gp130	29,34	ribonucleic acid	gp130	CHEBI:33697	25205(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Expression Expression|nmod|messenger messenger|amod|END_ENTITY	Expression and regulation of gp130 messenger ribonucleic_acid in cultured immature rat Sertoli cells .
10830294	0	ribonucleic_acid	96,112	growth_hormone	12,26	ribonucleic acid	growth hormone	CHEBI:33697	81668(Tax:10116)	Chemical	Gene	levels|amod|START_ENTITY expression|nmod|levels inhibit|dobj|expression inhibit|nsubj|levels levels|compound|END_ENTITY	High plasma growth_hormone -LRB- GH -RRB- levels inhibit expression of GH secretagogue receptor messenger ribonucleic_acid levels in the rat pituitary .
1624913	0	ribonucleic_acid	50,66	growth_hormone	11,25	ribonucleic acid	growth hormone	CHEBI:33697	2688	Chemical	Gene	START_ENTITY|nsubj|Changes Changes|nmod|messenger messenger|compound|END_ENTITY	Changes in growth_hormone and prolactin messenger ribonucleic_acid levels during seawater adaptation of amago salmon -LRB- Oncorhynchus rhodurus -RRB- .
2004472	0	ribonucleic_acid	55,71	growth_hormone	25,39	ribonucleic acid	growth hormone	CHEBI:33697	2688	Chemical	Gene	START_ENTITY|nsubj|relationship relationship|nmod|messenger messenger|compound|END_ENTITY	The relationship between growth_hormone -LRB- GH -RRB- messenger ribonucleic_acid levels and hormone release from individual cells derived from human GH-secreting pituitary_adenomas .
2152867	0	ribonucleic_acid	131,147	growth_hormone	23,37	ribonucleic acid	growth hormone	CHEBI:33697	81668(Tax:10116)	Chemical	Gene	messenger|acl|START_ENTITY splicing|nmod|messenger detection|nmod|splicing mechanism|dep|detection mechanism|nmod|deficiency deficiency|amod|END_ENTITY	Molecular mechanism of growth_hormone -LRB- GH -RRB- deficiency in the spontaneous dwarf rat : detection of abnormal splicing of GH messenger ribonucleic_acid by the polymerase chain reaction .
2307109	0	ribonucleic_acid	153,169	growth_hormone	54,68	ribonucleic acid	growth hormone	CHEBI:33697	2688	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|feeding feeding|nmod|concentrations concentrations|nmod|END_ENTITY	Effect of restricted feeding on the concentrations of growth_hormone -LRB- GH -RRB- , gonadotropins , and prolactin -LRB- PRL -RRB- in plasma , and on the amounts of messenger ribonucleic_acid for GH , gonadotropin subunits , and PRL in the pituitary glands of adult ovariectomized ewes .
2778032	0	ribonucleic_acid	53,69	growth_hormone	14,28	ribonucleic acid	growth hormone	CHEBI:33697	2688	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|secretion secretion|amod|END_ENTITY	Regulation of growth_hormone secretion and messenger ribonucleic_acid accumulation in human somatotropinoma cells in vitro .
3359980	0	ribonucleic_acid	63,79	growth_hormone	148,162	ribonucleic acid	growth hormone	CHEBI:33697	81668(Tax:10116)	Chemical	Gene	levels|amod|START_ENTITY Regulation|nmod|levels Regulation|dep|implications implications|nmod|autoregulation autoregulation|amod|END_ENTITY	Regulation of pituitary insulin-like_growth_factor-I messenger ribonucleic_acid levels in rats harboring somatomammotropic tumors : implications for growth_hormone autoregulation .
3882504	0	ribonucleic_acid	48,64	growth_hormone	23,37	ribonucleic acid	growth hormone	CHEBI:33697	81668(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|messenger messenger|compound|END_ENTITY	Insulin suppresses rat growth_hormone messenger ribonucleic_acid levels in rat pituitary_tumor cells .
5701666	0	ribonucleic_acid	28,44	growth_hormone	10,24	ribonucleic acid	growth hormone	CHEBI:33697	81668(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY Effect|nmod|metabolism Effect|nmod|END_ENTITY	Effect of growth_hormone on ribonucleic_acid metabolism .
5840717	0	ribonucleic_acid	28,44	growth_hormone	10,24	ribonucleic acid	growth hormone	CHEBI:33697	2688	Chemical	Gene	metabolism|amod|START_ENTITY Effect|nmod|metabolism Effect|nmod|END_ENTITY	Effect of growth_hormone on ribonucleic_acid metabolism .
5941353	0	ribonucleic_acid	104,120	growth_hormone	37,51	ribonucleic acid	growth hormone	CHEBI:33697	81668(Tax:10116)	Chemical	Gene	polymerase|amod|START_ENTITY END_ENTITY|nmod|polymerase	Additive effects of thyroid hormone , growth_hormone and testosterone on deoxyribonucleic_acid-dependent ribonucleic_acid polymerase in rat-liver nuclei .
8950599	0	ribonucleic_acid	80,96	growth_hormone	47,61	ribonucleic acid	growth hormone	CHEBI:33697	81668(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|identification identification|nmod|END_ENTITY	Simultaneous ultrastructural identification of growth_hormone and its messenger ribonucleic_acid using combined immunohistochemistry and non-radioisotopic in situ hybridization : a technical note .
2104584	0	ribonucleic_acid	74,90	growth_hormone-releasing_hormone	31,63	ribonucleic acid	growth hormone-releasing hormone	CHEBI:33697	29446(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Expression Expression|nmod|messenger messenger|amod|END_ENTITY	Expression and localization of growth_hormone-releasing_hormone messenger ribonucleic_acid in rat placenta : in vitro secretion and regulation of its peptide product .
10404796	0	ribonucleic_acid	42,58	growth_hormone_receptor	8,31	ribonucleic acid	growth hormone receptor	CHEBI:33697	2690	Chemical	Gene	START_ENTITY|nsubj|messenger messenger|compound|END_ENTITY	Reduced growth_hormone_receptor messenger ribonucleic_acid in an aged man with chronic malnutrition and growth hormone resistance .
10709921	0	ribonucleic_acid	64,80	growth_hormone_receptor	30,53	ribonucleic acid	growth hormone receptor	CHEBI:33697	397488(Tax:9823)	Chemical	Gene	START_ENTITY|nsubj|Expression Expression|nmod|variants variants|nmod|messenger messenger|compound|END_ENTITY	Expression of two variants of growth_hormone_receptor messenger ribonucleic_acid in porcine liver .
10946895	0	ribonucleic_acid	40,56	growth_hormone_receptor	61,84	ribonucleic acid	growth hormone receptor	CHEBI:33697	2690	Chemical	Gene	START_ENTITY|nmod|isoforms isoforms|compound|END_ENTITY	Distribution and abundance of messenger ribonucleic_acid for growth_hormone_receptor isoforms in human tissues .
8126150	0	ribonucleic_acid	50,66	growth_hormone_receptor	16,39	ribonucleic acid	growth hormone receptor	CHEBI:33697	2690	Chemical	Gene	START_ENTITY|nsubj|Distribution Distribution|nmod|messenger messenger|compound|END_ENTITY	Distribution of growth_hormone_receptor messenger ribonucleic_acid containing and lacking exon 3 in human tissues .
8440172	0	ribonucleic_acid	70,86	growth_hormone_receptor	36,59	ribonucleic acid	growth hormone receptor	CHEBI:33697	443333(Tax:9940)	Chemical	Gene	START_ENTITY|nsubj|distribution distribution|nmod|messenger messenger|compound|END_ENTITY	Tissue distribution and ontogeny of growth_hormone_receptor messenger ribonucleic_acid and ligand binding to hepatic tissue in the midgestation sheep fetus .
10819792	0	ribonucleic_acid	152,168	hepatocyte_growth_factor	211,235	ribonucleic acid	hepatocyte growth factor	CHEBI:33697	24446(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|hormone hormone|compound|END_ENTITY	Modulation of estrogen production and 17beta-hydroxysteroid_dehydrogenase-type_1 , cytochrome P450 aromatase , c-met , and protein kinase Balpha messenger ribonucleic_acid content in rat ovarian granulosa cells by hepatocyte_growth_factor and follicle-stimulating hormone .
3359980	0	ribonucleic_acid	63,79	insulin-like_growth_factor-I	24,52	ribonucleic acid	insulin-like growth factor-I	CHEBI:33697	24482(Tax:10116)	Chemical	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	Regulation of pituitary insulin-like_growth_factor-I messenger ribonucleic_acid levels in rats harboring somatomammotropic tumors : implications for growth_hormone autoregulation .
2458916	0	ribonucleic_acid	74,90	insulin-like_growth_factor_I	35,63	ribonucleic acid	insulin-like growth factor I	CHEBI:33697	24482(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|messenger messenger|compound|END_ENTITY	Dexamethasone reduces steady state insulin-like_growth_factor_I messenger ribonucleic_acid levels in rat neuronal and glial cells in primary culture .
8243280	0	ribonucleic_acid	75,91	interleukin-6	51,64	ribonucleic acid	interleukin-6	CHEBI:33697	24498(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|expression expression|nmod|messenger messenger|amod|END_ENTITY	Bacterial lipopolysaccharide-induced expression of interleukin-6 messenger ribonucleic_acid in the rat hypothalamus , pituitary , adrenal gland , and spleen .
9421394	0	ribonucleic_acid	49,65	leptin_receptor	16,31	ribonucleic acid	leptin receptor	CHEBI:33697	16847(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Localization Localization|nmod|messenger messenger|compound|END_ENTITY	Localization of leptin_receptor -LRB- Ob-R -RRB- messenger ribonucleic_acid in the rodent hindbrain .
7628399	0	ribonucleic_acid	88,104	luteinizing_hormone-releasing_hormone	40,77	ribonucleic acid	luteinizing hormone-releasing hormone	CHEBI:33697	25194(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	Effects of estrogen and progesterone on luteinizing_hormone-releasing_hormone messenger ribonucleic_acid levels : consideration of temporal and neuroanatomical variables .
8754771	0	ribonucleic_acid	172,188	luteinizing_hormone-releasing_hormone	30,67	ribonucleic acid	luteinizing hormone-releasing hormone	CHEBI:33697	25194(Tax:10116)	Chemical	Gene	decreases|ccomp|START_ENTITY decreases|nsubj|administration administration|nmod|cetrorelix cetrorelix|amod|END_ENTITY	Chronic administration of the luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- antagonist cetrorelix decreases gonadotrope responsiveness and pituitary LHRH receptor messenger ribonucleic_acid levels in rats .
9075729	0	ribonucleic_acid	137,153	luteinizing_hormone-releasing_hormone	63,100	ribonucleic acid	luteinizing hormone-releasing hormone	CHEBI:33697	25194(Tax:10116)	Chemical	Gene	messenger|acl|START_ENTITY synthesize|dobj|messenger synthesize|nsubj|neurons neurons|amod|END_ENTITY	Dual label in situ hybridization studies provide evidence that luteinizing_hormone-releasing_hormone neurons do not synthesize messenger ribonucleic_acid for mu , kappa , or delta opiate receptors .
12768791	0	ribonucleic_acid	80,96	matrix_metalloproteinase-1	19,45	ribonucleic acid	matrix metalloproteinase-1	CHEBI:33697	4312	Chemical	Gene	START_ENTITY|nsubj|expression expression|nmod|messenger messenger|amod|END_ENTITY	-LSB- The expression of matrix_metalloproteinase-1 and interleukin-1-alpha messenger ribonucleic_acid in human middle_ear_cholesteatoma -RSB- .
8954975	0	ribonucleic_acid	32,48	midkine	14,21	ribonucleic acid	midkine	CHEBI:33697	81517(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|messenger messenger|amod|END_ENTITY	Regulation of midkine messenger ribonucleic_acid levels in cultured rat granulosa cells .
7735294	0	ribonucleic_acid	75,91	neuropeptide_Y	8,22	ribonucleic acid	neuropeptide Y	CHEBI:33697	24604(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of neuropeptide_Y in the regulation of tyrosine hydroxylase messenger ribonucleic_acid levels in the male rat arcuate nucleus as evaluated by in situ hybridization .
11430882	0	ribonucleic_acid	77,93	orexin_receptor_2	49,66	ribonucleic acid	orexin receptor 2	CHEBI:33697	25605(Tax:10116)	Chemical	Gene	messenger|acl|START_ENTITY messenger|amod|END_ENTITY	Orexins : effects on behavior and localisation of orexin_receptor_2 messenger ribonucleic_acid in the rat brainstem .
10579336	0	ribonucleic_acid	156,172	oxytocin_receptor	38,55	ribonucleic acid	oxytocin receptor	CHEBI:33697	443138(Tax:9940)	Chemical	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Differential expression of myometrial oxytocin_receptor and prostaglandin_H synthase 2 , but not estrogen_receptor_alpha and heat_shock protein 90 messenger ribonucleic_acid in the gravid horn and nongravid horn in sheep during betamethasone-induced labor .
8396014	0	ribonucleic_acid	44,60	oxytocin_receptor	16,33	ribonucleic acid	oxytocin receptor	CHEBI:33697	25342(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Localization Localization|nmod|messenger messenger|compound|END_ENTITY	Localization of oxytocin_receptor messenger ribonucleic_acid in the rat brain .
9780319	0	ribonucleic_acid	45,61	oxytocin_receptor	17,34	ribonucleic acid	oxytocin receptor	CHEBI:33697	25342(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Up-regulation Up-regulation|nmod|messenger messenger|compound|END_ENTITY	Up-regulation of oxytocin_receptor messenger ribonucleic_acid and protein by estradiol in the cervix of ovariectomized rat .
9972675	0	ribonucleic_acid	30,46	p53	0,3	ribonucleic acid	p53	CHEBI:33697	7157	Chemical	Gene	START_ENTITY|nsubj|protein protein|compound|END_ENTITY	p53 protein and its messenger ribonucleic_acid in human adrenal_tumors .
9389509	0	ribonucleic_acid	79,95	peptidylglycine_alpha-amidating_monooxygenase	23,68	ribonucleic acid	peptidylglycine alpha-amidating monooxygenase	CHEBI:33697	25508(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|messenger messenger|amod|END_ENTITY	Estrogen regulation of peptidylglycine_alpha-amidating_monooxygenase messenger ribonucleic_acid levels by a nuclear posttranscriptional event .
9492018	0	ribonucleic_acid	137,153	peptidylglycine_alpha-amidating_monooxygenase	81,126	ribonucleic acid	peptidylglycine alpha-amidating monooxygenase	CHEBI:33697	5066	Chemical	Gene	messenger|acl|START_ENTITY messenger|amod|END_ENTITY	Identification of a novel cis-element in the 3 ' - untranslated region of mammalian peptidylglycine_alpha-amidating_monooxygenase messenger ribonucleic_acid .
8299576	1	ribonucleic_acid	112,128	pro-TRH	94,101	ribonucleic acid	pro-TRH	CHEBI:33697	25569(Tax:10116)	Chemical	Gene	messenger|amod|START_ENTITY messenger|amod|END_ENTITY	I. Presence of pro-TRH messenger ribonucleic_acid and pro-TRH-derived peptide in a subpopulation of somatotrophs .
2464133	0	ribonucleic_acid	43,59	proenkephalin	19,32	ribonucleic acid	proenkephalin	CHEBI:33697	29237(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|messenger messenger|compound|END_ENTITY	Estrogen increases proenkephalin messenger ribonucleic_acid levels in the ventromedial hypothalamus of the rat .
11474214	0	ribonucleic_acid	123,139	progesterone_receptor	91,112	ribonucleic acid	progesterone receptor	CHEBI:33697	25154(Tax:10116)	Chemical	Gene	messenger|acl|START_ENTITY messenger|compound|END_ENTITY	The endocrine disrupters butyl_benzyl_phthalate and bisphenol_A increase the expression of progesterone_receptor messenger ribonucleic_acid in the preoptic area of adult ovariectomized rats .
2651098	0	ribonucleic_acid	40,56	progesterone_receptor	141,162	ribonucleic acid	progesterone receptor	CHEBI:33697	5241	Chemical	Gene	down-regulation|nmod|START_ENTITY down-regulation|dep|correlation correlation|nmod|levels levels|compound|END_ENTITY	Autologous down-regulation of messenger ribonucleic_acid and protein levels for estrogen receptors in MCF-7 cells : an inverse correlation to progesterone_receptor levels .
3342760	0	ribonucleic_acid	46,62	progesterone_receptor	144,165	ribonucleic acid	progesterone receptor	CHEBI:33697	5241	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|dep|analysis analysis|nmod|effect effect|nmod|synthesis synthesis|compound|END_ENTITY	Regulation of progesterone_receptor messenger ribonucleic_acid and protein levels in MCF-7 cells by estradiol : analysis of estrogen 's effect on progesterone_receptor synthesis and degradation .
8797022	0	ribonucleic_acid	128,144	progesterone_receptor	96,117	ribonucleic acid	progesterone receptor	CHEBI:33697	25154(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Progesterone inhibits female-typical receptive behavior and decreases hypothalamic estrogen and progesterone_receptor messenger ribonucleic_acid levels in whiptail lizards -LRB- genus Cnemidophorus -RRB- .
9389534	0	ribonucleic_acid	46,62	progesterone_receptor	14,35	ribonucleic acid	progesterone receptor	CHEBI:33697	25154(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|messenger messenger|compound|END_ENTITY	Regulation of progesterone_receptor messenger ribonucleic_acid in the rat medial preoptic nucleus by estrogenic and antiestrogenic compounds : an in situ hybridization study .
9408241	0	ribonucleic_acid	46,62	progesterone_receptor	14,35	ribonucleic acid	progesterone receptor	CHEBI:33697	5241	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|messenger messenger|compound|END_ENTITY	Regulation of progesterone_receptor messenger ribonucleic_acid by progestin in human endometrial stromal cells .
9717846	0	ribonucleic_acid	58,74	progesterone_receptor	21,42	ribonucleic acid	progesterone receptor	CHEBI:33697	25154(Tax:10116)	Chemical	Gene	messenger|amod|START_ENTITY messenger|amod|END_ENTITY	Hormone induction of progesterone_receptor -LRB- PR -RRB- messenger ribonucleic_acid and activation of PR promoter regions in ovarian granulosa cells : evidence for a role of cyclic_adenosine_3 ' ,5 ' - monophosphate but not estradiol .
10456854	0	ribonucleic_acid	38,54	prolactin	18,27	ribonucleic acid	prolactin	CHEBI:33697	100303694(Tax:9103)	Chemical	Gene	content|amod|START_ENTITY messenger|dobj|content messenger|nsubj|Quantification Quantification|nmod|END_ENTITY	Quantification of prolactin messenger ribonucleic_acid , pituitary content and plasma levels of prolactin , and detection of immunoreactive isoforms of prolactin in pituitaries from turkey embryos during ontogeny .
10456854	0	ribonucleic_acid	38,54	prolactin	95,104	ribonucleic acid	prolactin	CHEBI:33697	100303694(Tax:9103)	Chemical	Gene	content|amod|START_ENTITY content|nmod|END_ENTITY	Quantification of prolactin messenger ribonucleic_acid , pituitary content and plasma levels of prolactin , and detection of immunoreactive isoforms of prolactin in pituitaries from turkey embryos during ontogeny .
11826766	0	ribonucleic_acid	10,26	prolactin	50,59	ribonucleic acid	prolactin	CHEBI:33697	19109(Tax:10090)	Chemical	Gene	START_ENTITY|advcl|present present|nsubjpass|END_ENTITY	Messenger ribonucleic_acid for the mouse decidual prolactin is present and induced during in vitro decidualization of endometrial stromal cells .
2002749	0	ribonucleic_acid	20,36	prolactin	111,120	ribonucleic acid	prolactin	CHEBI:33697	443317(Tax:9940)	Chemical	Gene	START_ENTITY|parataxis|amounts amounts|advmod|relative relative|nmod|serum serum|compound|END_ENTITY	Prolactin messenger ribonucleic_acid concentrations throughout the ovine estrous cycle : assessment relative to prolactin serum and pituitary amounts .
2464129	0	ribonucleic_acid	46,62	prolactin	20,29	ribonucleic acid	prolactin	CHEBI:33697	24683(Tax:10116)	Chemical	Gene	cells|amod|START_ENTITY cells|amod|Discrepancy Discrepancy|nmod|END_ENTITY	Discrepancy between prolactin -LRB- PRL -RRB- messenger ribonucleic_acid and PRL content in rat fetal pituitary cells : possible role of dopamine .
6194977	0	ribonucleic_acid	97,113	prolactin	53,62	ribonucleic acid	prolactin	CHEBI:33697	5617	Chemical	Gene	express|nmod|START_ENTITY required|xcomp|express required|nmod|END_ENTITY	Extracellular calcium ion concentration required for prolactin to express its actions on casein , ribonucleic_acid , and lipid biosynthesis in mouse mammary gland explants .
7683213	0	ribonucleic_acid	71,87	prolactin	51,60	ribonucleic acid	prolactin	CHEBI:33697	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|messenger messenger|compound|END_ENTITY	Mammary epithelial cells of lactating rats express prolactin messenger ribonucleic_acid .
8485553	0	ribonucleic_acid	47,63	prolactin	27,36	ribonucleic acid	prolactin	CHEBI:33697	24683(Tax:10116)	Chemical	Gene	poly|amod|START_ENTITY modulation|nsubj|poly modulation|nmod|regulation regulation|nmod|messenger messenger|compound|END_ENTITY	In vitro regulation of rat prolactin messenger ribonucleic_acid poly -LRB- A -RRB- tail length : modulation by bromocriptine .
9716559	0	ribonucleic_acid	101,117	prolactin	157,166	ribonucleic acid	prolactin	CHEBI:33697	24683(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|dep|induction induction|nmod|lactogens lactogens|compound|END_ENTITY	Hormonal regulation of copper-zinc_superoxide dismutase and manganese_superoxide dismutase messenger ribonucleic_acid in the rat corpus luteum : induction by prolactin and placental lactogens .
18162529	0	ribonucleic_acid	42,58	prolactin_receptor	13,31	ribonucleic acid	prolactin receptor	D012313	24684(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|messenger messenger|compound|END_ENTITY	Hypothalamic prolactin_receptor messenger ribonucleic_acid levels , prolactin signaling , and hyperprolactinemic inhibition of pulsatile luteinizing hormone secretion are dependent on estradiol .
11162901	0	ribonucleic_acid	44,60	proopiomelanocortin	14,33	ribonucleic acid	proopiomelanocortin	CHEBI:33697	443212(Tax:9940)	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|messenger messenger|compound|END_ENTITY	Regulation of proopiomelanocortin messenger ribonucleic_acid levels in the ovine fetal anterior pituitary in vitro .
1378571	0	ribonucleic_acid	83,99	proopiomelanocortin	53,72	ribonucleic acid	proopiomelanocortin	CHEBI:33697	18976(Tax:10090)	Chemical	Gene	messenger|acl|START_ENTITY messenger|compound|END_ENTITY	Aging impairs estrogenic suppression of hypothalamic proopiomelanocortin messenger ribonucleic_acid in the mouse .
2385358	0	ribonucleic_acid	44,60	proopiomelanocortin	14,33	ribonucleic acid	proopiomelanocortin	CHEBI:33697	24664(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|messenger messenger|compound|END_ENTITY	Regulation of proopiomelanocortin messenger ribonucleic_acid content by sex steroids in the arcuate nucleus of the female rat brain .
2933246	0	ribonucleic_acid	66,82	proopiomelanocortin	36,55	ribonucleic acid	proopiomelanocortin	CHEBI:33697	24664(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Estrogen decreases rat hypothalamic proopiomelanocortin messenger ribonucleic_acid levels .
3023021	0	ribonucleic_acid	92,108	proopiomelanocortin	62,81	ribonucleic acid	proopiomelanocortin	CHEBI:33697	24664(Tax:10116)	Chemical	Gene	messenger|acl|START_ENTITY messenger|compound|END_ENTITY	Calcium ion and cyclic_adenosine_3 ' ,5 ' - monophosphate regulate proopiomelanocortin messenger ribonucleic_acid levels in rat intermediate and anterior pituitary lobes .
3490963	0	ribonucleic_acid	156,172	proopiomelanocortin	104,123	ribonucleic acid	proopiomelanocortin	CHEBI:33697	24664(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY peptide|dobj|production peptide|nsubj|END_ENTITY	Calcium-independent and calcium-dependent mechanisms regulate corticotropin-releasing factor-stimulated proopiomelanocortin peptide secretion and messenger ribonucleic_acid production .
6093800	0	ribonucleic_acid	86,102	proopiomelanocortin	56,75	ribonucleic acid	proopiomelanocortin	CHEBI:33697	24664(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|messenger messenger|compound|END_ENTITY	Corticotropin-releasing_factor differentially regulates proopiomelanocortin messenger ribonucleic_acid levels in anterior as compared to intermediate pituitary lobes of rats .
7750460	0	ribonucleic_acid	111,127	somatostatin	24,36	ribonucleic acid	somatostatin	CHEBI:33697	6750	Chemical	Gene	messenger|acl|START_ENTITY degradation|nmod|messenger inhibit|nmod|degradation inhibit|dobj|expression expression|compound|END_ENTITY	Glucocorticoids inhibit somatostatin gene expression through accelerated degradation of somatostatin messenger ribonucleic_acid in human thyroid_medullary_carcinoma -LRB- TT -RRB- cells .
7750460	0	ribonucleic_acid	111,127	somatostatin	88,100	ribonucleic acid	somatostatin	CHEBI:33697	6750	Chemical	Gene	messenger|acl|START_ENTITY messenger|compound|END_ENTITY	Glucocorticoids inhibit somatostatin gene expression through accelerated degradation of somatostatin messenger ribonucleic_acid in human thyroid_medullary_carcinoma -LRB- TT -RRB- cells .
9322956	0	ribonucleic_acid	64,80	somatostatin	41,53	ribonucleic acid	somatostatin	CHEBI:33697	6750	Chemical	Gene	START_ENTITY|nsubj|messenger messenger|compound|END_ENTITY	Transforming growth factor-betas inhibit somatostatin messenger ribonucleic_acid levels and somatostatin secretion in hypothalamic cells in culture .
9864065	0	ribonucleic_acid	46,62	somatostatin	23,35	ribonucleic acid	somatostatin	CHEBI:33697	24797(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|messenger messenger|compound|END_ENTITY	Somatostatin decreases somatostatin messenger ribonucleic_acid levels in the rat periventricular nucleus .
1547732	0	ribonucleic_acid	60,76	sulfated_glycoprotein-2	14,37	ribonucleic acid	sulfated glycoprotein-2	CHEBI:33697	24854(Tax:10116)	Chemical	Gene	messenger|acl|START_ENTITY messenger|amod|END_ENTITY	Regulation of sulfated_glycoprotein-2 -LRB- clusterin -RRB- messenger ribonucleic_acid in the rat epididymis .
2853971	0	ribonucleic_acid	72,88	tRNA_ligase	35,46	ribonucleic acid	tRNA ligase	CHEBI:33697	853358(Tax:4932)	Chemical	Gene	START_ENTITY|nsubj|interactions interactions|nmod|END_ENTITY	Binding interactions between yeast tRNA_ligase and a precursor transfer ribonucleic_acid containing two photoreactive uridine analogues .
10566646	0	ribonucleic_acid	100,116	thyroglobulin	76,89	ribonucleic acid	thyroglobulin	CHEBI:33697	7038	Chemical	Gene	START_ENTITY|nsubj|reaction reaction|acl|circulating circulating|dobj|messenger messenger|compound|END_ENTITY	Quantitative reverse transcription-polymerase chain reaction of circulating thyroglobulin messenger ribonucleic_acid for monitoring patients with thyroid_carcinoma .
11061512	0	ribonucleic_acid	161,177	thyroglobulin	109,122	ribonucleic acid	thyroglobulin	CHEBI:33697	7038	Chemical	Gene	transcripts|amod|START_ENTITY transcripts|compound|END_ENTITY	Detection of recurrent thyroid_cancer by sensitive nested reverse transcription-polymerase chain reaction of thyroglobulin and sodium/iodide symporter messenger ribonucleic_acid transcripts in peripheral blood .
14715824	0	ribonucleic_acid	49,65	thyroglobulin	25,38	ribonucleic acid	thyroglobulin	CHEBI:33697	7038	Chemical	Gene	messenger|acl|START_ENTITY messenger|compound|END_ENTITY	Low specificity of blood thyroglobulin messenger ribonucleic_acid assay prevents its use in the follow-up of differentiated thyroid_cancer patients .
15687333	0	ribonucleic_acid	45,61	thyroglobulin	21,34	ribonucleic acid	thyroglobulin	CHEBI:33697	7038	Chemical	Gene	START_ENTITY|nsubj|messenger messenger|compound|END_ENTITY	Thyrotropin_receptor / thyroglobulin messenger ribonucleic_acid in peripheral blood and fine-needle aspiration cytology : diagnostic synergy for detecting thyroid_cancer .
2584351	0	ribonucleic_acid	38,54	thyroglobulin	14,27	ribonucleic acid	thyroglobulin	CHEBI:33697	7038	Chemical	Gene	START_ENTITY|nsubj|levels levels|nmod|messenger messenger|compound|END_ENTITY	Low levels of thyroglobulin messenger ribonucleic_acid in congenital goitrous_hypothyroidism with defective_thyroglobulin_synthesis .
2642421	0	ribonucleic_acid	37,53	thyroglobulin	13,26	ribonucleic acid	thyroglobulin	CHEBI:33697	100750237	Chemical	Gene	messenger|acl|START_ENTITY messenger|compound|END_ENTITY	Normal-sized thyroglobulin messenger ribonucleic_acid in Dutch goats with a thyroglobulin_synthesis_defect is translated into a 35,000 molecular weight N-terminal fragment .
3745406	0	ribonucleic_acid	40,56	thyroglobulin	16,29	ribonucleic acid	thyroglobulin	CHEBI:33697	7038	Chemical	Gene	START_ENTITY|nsubj|level level|nmod|messenger messenger|compound|END_ENTITY	Normal level of thyroglobulin messenger ribonucleic_acid in a human congenital_goiter with thyroglobulin deficiency .
3745406	0	ribonucleic_acid	40,56	thyroglobulin	91,104	ribonucleic acid	thyroglobulin	CHEBI:33697	7038	Chemical	Gene	START_ENTITY|nmod|deficiency deficiency|compound|END_ENTITY	Normal level of thyroglobulin messenger ribonucleic_acid in a human congenital_goiter with thyroglobulin deficiency .
9851791	0	ribonucleic_acid	105,121	thyroglobulin	81,94	ribonucleic acid	thyroglobulin	CHEBI:33697	7038	Chemical	Gene	START_ENTITY|nsubj|diagnosis diagnosis|nmod|thyroid_cancer thyroid_cancer|nmod|amplification amplification|nmod|messenger messenger|compound|END_ENTITY	Molecular diagnosis of residual and recurrent thyroid_cancer by amplification of thyroglobulin messenger ribonucleic_acid in peripheral blood .
2542003	0	ribonucleic_acid	55,71	thyroid_peroxidase	26,44	ribonucleic acid	thyroid peroxidase	CHEBI:33697	54314(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	Thyrotropin regulation of thyroid_peroxidase messenger ribonucleic_acid levels in cultured rat thyroid cells : evidence for the involvement of a nontranscriptional mechanism .
3139993	0	ribonucleic_acid	67,83	tissue-type_plasminogen_activator	23,56	ribonucleic acid	tissue-type plasminogen activator	CHEBI:33697	25692(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|messenger messenger|amod|END_ENTITY	Hormonal regulation of tissue-type_plasminogen_activator messenger ribonucleic_acid levels in rat granulosa cells : mechanisms of induction by follicle-stimulating hormone and gonadotropin releasing hormone .
8166201	0	ribonucleic_acid	58,74	transforming_growth_factor-beta_1	14,47	ribonucleic acid	transforming growth factor-beta 1	CHEBI:33697	7040	Chemical	Gene	START_ENTITY|nsubj|Expression Expression|nmod|messenger messenger|amod|END_ENTITY	Expression of transforming_growth_factor-beta_1 messenger ribonucleic_acid and the modulation of deoxyribonucleic_acid synthesis by transforming_growth_factor-beta_1 in human endometrial cells .
1280203	0	ribonucleic_acid	96,112	transforming_growth_factor-beta_2	39,72	ribonucleic acid	transforming growth factor-beta 2	CHEBI:33697	81809(Tax:10116)	Chemical	Gene	messenger|acl|START_ENTITY messenger|amod|END_ENTITY	Porcine granulosa cells do not express transforming_growth_factor-beta_2 -LRB- TGF-beta_2 -RRB- messenger ribonucleic_acid : molecular basis for their inability to produce TGF-beta activity comparable to that of rat granulosa cells .
1426318	0	ribonucleic_acid	79,95	tumor_necrosis_factor_alpha	41,68	ribonucleic acid	tumor necrosis factor alpha	CHEBI:33697	7124	Chemical	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Ovarian steroids modulate human monocyte tumor_necrosis_factor_alpha messenger ribonucleic_acid levels in cultured human peripheral monocytes .
11174499	0	ribonucleic_acid	93,109	vascular_endothelial_growth_factor	48,82	ribonucleic acid	vascular endothelial growth factor	CHEBI:33697	443103(Tax:9940)	Chemical	Gene	messenger|acl|START_ENTITY messenger|compound|END_ENTITY	Fetal esophageal ligation induces expression of vascular_endothelial_growth_factor messenger ribonucleic_acid in fetal membranes .
10843188	0	ribonucleic_acid	49,65	vitamin_D_receptor	20,38	ribonucleic acid	vitamin D receptor	CHEBI:33697	7421	Chemical	Gene	START_ENTITY|nsubj|messenger messenger|compound|END_ENTITY	Reduced parathyroid vitamin_D_receptor messenger ribonucleic_acid levels in primary and secondary hyperparathyroidism .
1335319	0	ribonucleic_acid	75,91	vitamin_D_receptor	46,64	ribonucleic acid	vitamin D receptor	CHEBI:33697	22337(Tax:10090)	Chemical	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	1,25-Dihydroxyvitamin _ D3 does not up-regulate vitamin_D_receptor messenger ribonucleic_acid levels in hypophosphatemic mice .
7559881	0	ribonucleic_acid	49,65	vitamin_D_receptor	20,38	ribonucleic acid	vitamin D receptor	CHEBI:33697	7421	Chemical	Gene	START_ENTITY|nsubj|Evidence Evidence|nmod|messenger messenger|compound|END_ENTITY	Evidence for normal vitamin_D_receptor messenger ribonucleic_acid and genotype in absorptive hypercalciuria .
8612525	0	ribonucleic_acid	89,105	vitamin_D_receptor	188,206	ribonucleic acid	vitamin D receptor	CHEBI:33697	7421	Chemical	Gene	START_ENTITY|advcl|level level|compound|END_ENTITY	1,25-Dihydroxyvitamin _ D3 enhances the enzymatic activity and expression of the messenger ribonucleic_acid for aromatase cytochrome P450 synergistically with dexamethasone depending on the vitamin_D_receptor level in cultured human osteoblasts .
1535312	0	ribonucleic_acids	58,75	V1a	16,19	ribonucleic acids	V1a	CHEBI:33697	25107(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Distribution Distribution|nmod|END_ENTITY	Distribution of V1a and V2 vasopressin receptor messenger ribonucleic_acids in rat liver , kidney , pituitary and brain .
70428	1	ribonucleic_acids	91,108	beta2	123,128	ribonucleic acids	beta2	CHEBI:33697	10242	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of viral and nonviral ribonucleic_acids to the alpha , beta2 , and alphabeta forms of the enzyme .
1338729	0	ribonucleic_acids	53,70	c-fos	27,32	ribonucleic acids	c-fos	CHEBI:33697	314322(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|messenger messenger|amod|END_ENTITY	Gonadotropin regulation of c-fos and c-jun messenger ribonucleic_acids in cultured rat granulosa cells .
9854589	0	ribonucleic_acids	59,76	calcium-sensing_receptor	24,48	ribonucleic acids	calcium-sensing receptor	CHEBI:33697	846	Chemical	Gene	START_ENTITY|nsubj|expression expression|nmod|messenger messenger|amod|END_ENTITY	Decreased expression of calcium-sensing_receptor messenger ribonucleic_acids in parathyroid_adenomas .
1446636	0	ribonucleic_acids	65,82	cytochrome_P450scc	20,38	ribonucleic acids	cytochrome P450scc	CHEBI:33697	1583	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of human cytochrome_P450scc and adrenodoxin messenger ribonucleic_acids in JEG-3 cytotrophoblast cells .
8119165	0	ribonucleic_acids	54,71	follistatin	32,43	ribonucleic acids	follistatin	CHEBI:33697	24373(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|messenger messenger|compound|END_ENTITY	Dynamic regulation of pituitary follistatin messenger ribonucleic_acids during the rat estrous cycle .
10833369	0	ribonucleic_acids	122,139	leukaemia_inhibitory_factor	34,61	ribonucleic acids	leukaemia inhibitory factor	CHEBI:33697	3976	Chemical	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Pregnancy-dependent expression of leukaemia_inhibitory_factor -LRB- LIF -RRB- , LIF receptor-beta and interleukin-6 -LRB- IL-6 -RRB- messenger ribonucleic_acids in the porcine female reproductive tract .
10860830	0	ribonucleic_acids	44,61	maf-1	28,33	ribonucleic acids	maf-1	CHEBI:33697	315093(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|expression expression|nmod|messenger messenger|amod|END_ENTITY	Developmental expression of maf-1 messenger ribonucleic_acids in rat kidney by in situ hybridization histochemistry .
2395335	0	ribonucleic_acids	71,88	prolactin	32,41	ribonucleic acids	prolactin	CHEBI:33697	5617	Chemical	Gene	START_ENTITY|nsubj|localization localization|nmod|messenger messenger|compound|END_ENTITY	Ultrastructural localization of prolactin and chromogranin_B messenger ribonucleic_acids with biotinylated oligonucleotide probes in cultured pituitary cells .
1381371	0	ribonucleic_acids	60,77	renin	16,21	ribonucleic acids	renin	CHEBI:33697	5972	Chemical	Gene	START_ENTITY|nsubj|Coexpression Coexpression|nmod|END_ENTITY	Coexpression of renin , angiotensinogen , and their messenger ribonucleic_acids in adrenal tissues .
9166690	0	ribonucleic_acids	84,101	vascular_endothelial_growth_factor	14,48	ribonucleic acids	vascular endothelial growth factor	CHEBI:33697	7422	Chemical	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and VEGF-receptor messenger ribonucleic_acids in the peri-implantation rabbit uterus .
19345262	0	ribonucleoprotein	34,51	40LoVe	16,22	ribonucleoprotein	40LoVe	null	380181(Tax:8355)	Chemical	Gene	complex|compound|START_ENTITY END_ENTITY|nmod|complex	Interactions of 40LoVe within the ribonucleoprotein complex that forms on the localization element of Xenopus Vg1 mRNA .
15303970	0	ribonucleoprotein	30,47	Staufen	20,27	ribonucleoprotein	Staufen	null	37065(Tax:7227)	Chemical	Gene	START_ENTITY|nsubj|Characterization Characterization|nmod|END_ENTITY	Characterization of Staufen 1 ribonucleoprotein complexes .
21670278	0	ribonucleoprotein	59,76	Tudor_domain_containing_7	0,25	ribonucleoprotein	Tudor domain containing 7	null	23424	Chemical	Gene	essential|nmod|START_ENTITY essential|nsubj|END_ENTITY	Tudor_domain_containing_7 -LRB- Tdrd7 -RRB- is essential for dynamic ribonucleoprotein -LRB- RNP -RRB- remodeling of chromatoid bodies during spermatogenesis .
14614102	0	ribonucleoprotein	39,56	beta-actin	18,28	ribonucleoprotein	beta-actin	null	728378	Chemical	Gene	complex|compound|START_ENTITY complex|amod|END_ENTITY	Localization of a beta-actin messenger ribonucleoprotein complex with zipcode-binding protein modulates the density of dendritic_filopodia and filopodial synapses .
16600900	0	ribonucleotide	94,108	CRT10	39,44	ribonucleotide	CRT10	CHEBI:26561	854091(Tax:4932)	Chemical	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification and characterization of CRT10 as a novel regulator of Saccharomyces_cerevisiae ribonucleotide reductase genes .
1748682	0	ribonucleotide	19,33	H-ras	110,115	ribonucleotide	H-ras	CHEBI:26561	3265	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|transforming_growth_factor_beta_1 transforming_growth_factor_beta_1|nmod|END_ENTITY	Early induction of ribonucleotide reductase gene expression by transforming_growth_factor_beta_1 in malignant H-ras transformed cell lines .
7505277	0	ribonucleotide	69,83	H-ras	123,128	ribonucleotide	H-ras	CHEBI:26561	15461(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Alterations in the cyclic_AMP signal transduction pathway regulating ribonucleotide reductase gene expression in malignant H-ras transformed cell lines .
7768988	0	ribonucleotide	68,82	H-ras	28,33	ribonucleotide	H-ras	CHEBI:26561	15461(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY regulation|nmod|expression results|nmod|regulation results|nsubj|transformation transformation|nmod|END_ENTITY	Malignant transformation by H-ras results in aberrant regulation of ribonucleotide reductase gene expression by transforming_growth_factor-beta_1 .
19015526	0	ribonucleotide	50,64	MDM2	111,115	ribonucleotide	MDM2	CHEBI:26561	4193	Chemical	Gene	protein|compound|START_ENTITY protein|nmod|END_ENTITY	ATM-mediated serine 72 phosphorylation stabilizes ribonucleotide reductase small subunit p53R2 protein against MDM2 to DNA damage .
21614643	0	ribonucleotide	94,108	RNR2	120,124	ribonucleotide	RNR2	CHEBI:26561	821937(Tax:3702)	Chemical	Gene	reductase|amod|START_ENTITY reductase|appos|END_ENTITY	COP9 signalosome subunit 7 from Arabidopsis interacts with and regulates the small subunit of ribonucleotide reductase -LRB- RNR2 -RRB- .
10191191	5	ribonucleotide	1321,1335	RR1	1347,1350	ribonucleotide	RR1	CHEBI:26561	6240	Chemical	Gene	reductase|amod|START_ENTITY reductase|appos|END_ENTITY	To measure the CTL responses induced by the HSV alpha-mutants , we have targeted two H-2Kb-restricted CTL epitopes : an epitope in a virion protein , gB -LRB- 498-505 -RRB- , and an epitope in a nonvirion protein , ribonucleotide reductase -LRB- RR1 822-829 -RRB- .
20223551	0	ribonucleotide	42,56	RRM1	90,94	ribonucleotide	RRM1	CHEBI:26561	6240	Chemical	Gene	reductase|amod|START_ENTITY protein|amod|reductase protein|appos|END_ENTITY	The immunohistochemical overexpression of ribonucleotide reductase regulatory subunit M1 -LRB- RRM1 -RRB- protein is a predictor of shorter survival to gemcitabine-based chemotherapy in advanced non-small_cell_lung_cancer -LRB- NSCLC -RRB- .
21163702	0	ribonucleotide	4,18	RRM1	44,48	ribonucleotide	RRM1	CHEBI:26561	6240	Chemical	Gene	reductase|amod|START_ENTITY subunit|amod|reductase subunit|appos|END_ENTITY	The ribonucleotide reductase large subunit -LRB- RRM1 -RRB- as a predictive factor in patients with cancer .
23253379	0	ribonucleotide	91,105	RRM1	139,143	ribonucleotide	RRM1	CHEBI:26561	6240	Chemical	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Combined analysis of intratumoral human equilibrative nucleoside transporter 1 -LRB- hENT1 -RRB- and ribonucleotide reductase regulatory subunit M1 -LRB- RRM1 -RRB- expression is a powerful predictor of survival in patients with pancreatic_carcinoma treated with adjuvant gemcitabine-based chemotherapy after operative resection .
7557993	0	ribonucleotide	36,50	RRM1	62,66	ribonucleotide	RRM1	CHEBI:26561	6240	Chemical	Gene	reductase|amod|START_ENTITY reductase|appos|END_ENTITY	Human gene for the large subunit of ribonucleotide reductase -LRB- RRM1 -RRB- : functional analysis of the promoter .
17404105	0	ribonucleotide	27,41	RRM2	60,64	ribonucleotide	RRM2	CHEBI:26561	6241	Chemical	Gene	reductase|amod|START_ENTITY inhibitors|nmod|reductase subunit|nsubj|inhibitors subunit|ccomp|reduce reduce|nsubj|END_ENTITY	Potent siRNA inhibitors of ribonucleotide reductase subunit RRM2 reduce cell proliferation in vitro and in vivo .
18941749	0	ribonucleotide	82,96	RRM2	108,112	ribonucleotide	RRM2	CHEBI:26561	6241	Chemical	Gene	reductase|amod|START_ENTITY reductase|appos|END_ENTITY	Evaluation of mRNA by Q-RTPCR and protein expression by AQUA of the M2 subunit of ribonucleotide reductase -LRB- RRM2 -RRB- in human tumors .
20825972	0	ribonucleotide	14,28	RRM2	83,87	ribonucleotide	RRM2	CHEBI:26561	6241	Chemical	Gene	Expression|nmod|START_ENTITY reductase|nsubj|Expression reductase|dobj|subunit subunit|nmod|inhibition inhibition|nummod|END_ENTITY	Expression of ribonucleotide reductase M2 subunit in gastric_cancer and effects of RRM2 inhibition in vitro .
25378334	0	ribonucleotide	58,72	Rnr2	112,116	ribonucleotide	Rnr2	CHEBI:26561	6053	Chemical	Gene	activity|amod|START_ENTITY inhibits|dobj|activity inhibits|nmod|subunit subunit|amod|END_ENTITY	Hug1 is an intrinsically disordered protein that inhibits ribonucleotide reductase activity by directly binding Rnr2 subunit .
24600515	0	ribonucleotide	58,72	Thioredoxin	0,11	ribonucleotide	Thioredoxin	CHEBI:26561	7295	Chemical	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	Thioredoxin and glutaredoxin-mediated redox regulation of ribonucleotide reductase .
25256246	1	ribonucleotide	122,136	hRNR	148,152	ribonucleotide	hRNR	CHEBI:26561	10002	Chemical	Gene	reductase|compound|START_ENTITY reductase|appos|END_ENTITY	Human ribonucleotide reductase -LRB- hRNR -RRB- is a target of nucleotide chemotherapeutics in clinical use .
10980602	0	ribonucleotide	2,16	p53	63,66	ribonucleotide	p53	CHEBI:26561	7157	Chemical	Gene	gene|amod|START_ENTITY target|nsubj|gene target|nmod|END_ENTITY	A ribonucleotide reductase gene is a transcriptional target of p53 and p73 .
15096505	0	ribonucleotide	40,54	p53	114,117	ribonucleotide	p53	CHEBI:26561	7157	Chemical	Gene	reductase|amod|START_ENTITY reductase|nmod|HCT-116 HCT-116|compound|END_ENTITY	Stable suppression of the R2 subunit of ribonucleotide reductase by R2-targeted short interference RNA sensitizes p53 -LRB- - / - -RRB- HCT-116 colon_cancer cells to DNA-damaging agents and ribonucleotide reductase inhibitors .
16619496	0	ribonucleotide	21,35	p53	7,10	ribonucleotide	p53	CHEBI:26561	7157	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	P53R2 , p53 inducible ribonucleotide reductase gene , correlated with tumor progression of non-small cell lung_cancer .
19929413	0	ribonucleotide	46,60	p53	120,123	ribonucleotide	p53	CHEBI:26561	7157	Chemical	Gene	reductase|amod|START_ENTITY inhibiting|dobj|reductase Modulating|advcl|inhibiting silenced|csubj|Modulating silenced|dobj|protein protein|compound|END_ENTITY	Modulating radiation resistance by inhibiting ribonucleotide reductase in cancers with virally or mutationally silenced p53 protein .
14729598	0	ribonucleotide	95,109	p53R2	72,77	ribonucleotide	p53R2	CHEBI:26561	50484	Chemical	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	In vitro characterization of enzymatic properties and inhibition of the p53R2 subunit of human ribonucleotide reductase .
19015526	0	ribonucleotide	50,64	p53R2	89,94	ribonucleotide	p53R2	CHEBI:26561	50484	Chemical	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	ATM-mediated serine 72 phosphorylation stabilizes ribonucleotide reductase small subunit p53R2 protein against MDM2 to DNA damage .
19176520	0	ribonucleotide	94,108	thioredoxin	24,35	ribonucleotide	thioredoxin	CHEBI:26561	7295	Chemical	Gene	reductase|compound|START_ENTITY reductase|nsubj|mechanisms mechanisms|nmod|END_ENTITY	Molecular mechanisms of thioredoxin and glutaredoxin as hydrogen donors for Mammalian s phase ribonucleotide reductase .
19369702	0	ribonucleotide	89,103	thioredoxin	49,60	ribonucleotide	thioredoxin	CHEBI:26561	7295	Chemical	Gene	reductase|amod|START_ENTITY inactivation|nmod|reductase oxidation|dep|inactivation oxidation|nmod|END_ENTITY	Reactive oxygen species-independent oxidation of thioredoxin in hypoxia : inactivation of ribonucleotide reductase and redox-mediated checkpoint control .
2832522	0	ribonucleotide	73,87	thioredoxin	130,141	ribonucleotide	thioredoxin	CHEBI:26561	7295	Chemical	Gene	reductase|compound|START_ENTITY donor|nmod|reductase END_ENTITY|nsubj|donor	The principal hydrogen donor for the herpes_simplex_virus_type_1-encoded ribonucleotide reductase in infected cells is a cellular thioredoxin .
6358204	0	ribonucleotide	121,135	thioredoxin	16,27	ribonucleotide	thioredoxin	CHEBI:26561	100359245(Tax:9986)	Chemical	Gene	reductase|amod|START_ENTITY donor|nmod|reductase serve|nmod|donor fails|xcomp|serve marrow|acl:relcl|fails purified|nmod|marrow purified|nsubj|Properties Properties|nmod|END_ENTITY	Properties of a thioredoxin purified from rabbit bone marrow which fails to serve as a hydrogen donor for the homologous ribonucleotide reductase .
1748682	0	ribonucleotide	19,33	transforming_growth_factor_beta_1	63,96	ribonucleotide	transforming growth factor beta 1	CHEBI:26561	7040	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Early induction of ribonucleotide reductase gene expression by transforming_growth_factor_beta_1 in malignant H-ras transformed cell lines .
1709734	0	ribonucleotides	74,89	Mg2	33,36	ribonucleotides	Mg2	MESH:D012265	4589	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of metal ions , including Mg2 + and lanthanides , on the cleavage of ribonucleotides and RNA model compounds .
10728670	0	ribose	89,95	Transforming_growth_factor_beta2	0,32	ribose	Transforming growth factor beta2	MESH:D012266	7042	Chemical	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Transforming_growth_factor_beta2 promotes glucose_carbon incorporation into nucleic acid ribose through the nonoxidative pentose cycle in lung epithelial_carcinoma cells .
9435525	0	riboside	5,13	AMP-activated_protein_kinase	24,52	riboside	AMP-activated protein kinase	null	78975(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	AICA riboside increases AMP-activated_protein_kinase , fatty_acid oxidation , and glucose uptake in rat muscle .
6187376	0	ricin_A	34,41	alpha_2-macroglobulin	7,28	ricin A	alpha 2-macroglobulin	null	2	Chemical	Gene	chain|compound|START_ENTITY END_ENTITY|nmod|chain	Arming alpha_2-macroglobulin with ricin_A chain forms a cytotoxic conjugate that inhibits protein synthesis and kills human fibroblasts .
20855840	0	ridaforolimus	37,50	mTOR	22,26	ridaforolimus	mTOR	MESH:C515074	21977(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|study study|nmod|inhibitor inhibitor|compound|END_ENTITY	Phase IB study of the mTOR inhibitor ridaforolimus with capecitabine .
22143378	0	ridaforolimus	18,31	mTOR	41,45	ridaforolimus	mTOR	MESH:C515074	21977(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Phase I study for ridaforolimus , an oral mTOR inhibitor , in Japanese patients with advanced solid tumors .
22231376	0	ridaforolimus	63,76	mTOR	48,52	ridaforolimus	mTOR	MESH:C515074	21977(Tax:10090)	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|Analysis Analysis|nmod|activity activity|nmod|END_ENTITY	Analysis of the pharmacodynamic activity of the mTOR inhibitor ridaforolimus -LRB- AP23573 , MK-8669 -RRB- in a phase 1 clinical trial .
22614157	0	ridaforolimus	43,56	mTOR	28,32	ridaforolimus	mTOR	MESH:C515074	21977(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|activity activity|nmod|inhibitor inhibitor|compound|END_ENTITY	Synergistic activity of the mTOR inhibitor ridaforolimus and the antiandrogen bicalutamide in prostate_cancer models .
22695254	0	ridaforolimus	63,76	mTOR	48,52	ridaforolimus	mTOR	MESH:C515074	21977(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|analysis analysis|nmod|inhibitor inhibitor|compound|END_ENTITY	Safety and preliminary efficacy analysis of the mTOR inhibitor ridaforolimus in patients with taxane-treated , castration-resistant prostate_cancer .
26091915	0	ridaforolimus	36,49	mTOR	21,25	ridaforolimus	mTOR	MESH:C515074	21977(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|study study|nmod|inhibitor inhibitor|compound|END_ENTITY	Phase I study of the mTOR inhibitor ridaforolimus and the HDAC inhibitor vorinostat in advanced renal_cell_carcinoma and other solid_tumors .
22067397	0	ridaforolimus	62,75	mammalian_target_of_rapamycin	22,51	ridaforolimus	mammalian target of rapamycin	MESH:C515074	2475	Chemical	Gene	START_ENTITY|nsubj|study study|nmod|inhibitor inhibitor|compound|END_ENTITY	Phase II study of the mammalian_target_of_rapamycin inhibitor ridaforolimus in patients with advanced bone and soft tissue sarcomas .
26482301	0	rifabutin	63,72	SLCO1B1	14,21	rifabutin	SLCO1B1	MESH:D017828	10599	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY polymorphisms|nmod|pharmacokinetics polymorphisms|nsubj|effect effect|nmod|END_ENTITY	The effect of SLCO1B1 polymorphisms on the pharmacokinetics of rifabutin in African HIV-infected patients with tuberculosis .
19371336	0	rifampicin	74,84	CYP2E1	5,11	rifampicin	CYP2E1	MESH:D012293	1571	Chemical	Gene	play|nmod|START_ENTITY play|nsubj|END_ENTITY	Does CYP2E1 play a major role in the aggravation of isoniazid_toxicity by rifampicin in human hepatocytes ?
10570062	0	rifampicin	90,100	CYP3A4	80,86	rifampicin	CYP3A4	MESH:D012293	1576	Chemical	Gene	mediates|nmod|START_ENTITY mediates|dobj|activation activation|nmod|END_ENTITY	The orphan human pregnane_X_receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module .
16847425	0	rifampicin	57,67	CYP3A4	47,53	rifampicin	CYP3A4	MESH:D012293	1576	Chemical	Gene	polymorphism|nmod|START_ENTITY polymorphism|nmod|induction induction|nmod|END_ENTITY	Effect of SLCO1B1 polymorphism on induction of CYP3A4 by rifampicin .
19356089	0	rifampicin	34,44	CYP3A4	125,131	rifampicin	CYP3A4	MESH:D012293	1576	Chemical	Gene	exposure|compound|START_ENTITY relationship|nmod|exposure relationship|dep|extrapolation extrapolation|nmod|potential potential|compound|END_ENTITY	Quantitative relationship between rifampicin exposure and induction of Cyp3a11 in SXR humanized mice : extrapolation to human CYP3A4 induction potential .
23393219	0	rifampicin	199,209	CYP3A4	146,152	rifampicin	CYP3A4	MESH:D012293	1576	Chemical	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	Quantitative prediction of repaglinide-rifampicin complex drug interactions using dynamic and static mechanistic models : delineating differential CYP3A4 induction and OATP1B1 inhibition potential of rifampicin .
23674608	0	rifampicin	97,107	CYP3A4	77,83	rifampicin	CYP3A4	MESH:D012293	1576	Chemical	Gene	induction|nmod|START_ENTITY induction|nsubj|Comparison Comparison|nmod|endogenous endogenous|amod|4b-hydroxycholesterol 4b-hydroxycholesterol|nmod|midazolam midazolam|nmod|markers markers|nmod|END_ENTITY	Comparison of endogenous 4b-hydroxycholesterol with midazolam as markers for CYP3A4 induction by rifampicin .
24474302	0	rifampicin	14,24	CYP3A4	41,47	rifampicin	CYP3A4	MESH:D012293	1576	Chemical	Gene	START_ENTITY|appos|inducer inducer|compound|END_ENTITY	The effect of rifampicin , a prototypical CYP3A4 inducer , on erlotinib pharmacokinetics in healthy subjects .
24530864	0	rifampicin	70,80	CYP3A4	50,56	rifampicin	CYP3A4	MESH:D012293	1576	Chemical	Gene	induction|nmod|START_ENTITY induction|nummod|END_ENTITY	Physiologically based pharmacokinetic modeling of CYP3A4 induction by rifampicin in human : influence of time between substrate and inducer administration .
18650803	0	rifampicin	29,39	Cytochrome_P450	0,15	rifampicin	Cytochrome P450	MESH:D012293	4051	Chemical	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Cytochrome_P450 induction by rifampicin in healthy subjects : determination using the Karolinska cocktail and the endogenous CYP3A4 marker 4beta-hydroxycholesterol .
1418078	0	rifampicin	93,103	Fibrinogen	0,10	rifampicin	Fibrinogen	MESH:D012293	2244	Chemical	Gene	administration|compound|START_ENTITY END_ENTITY|nmod|administration	Fibrinogen and antithrombin III blood levels fluctuations during isoniazid or isoniazid plus rifampicin administration .
10408915	0	rifampicin	72,82	MRP	55,58	rifampicin	MRP	MESH:D012293	8714	Chemical	Gene	activity|nmod|START_ENTITY activity|appos|END_ENTITY	Inhibition of multidrug_resistance-associated_protein -LRB- MRP -RRB- activity by rifampicin in human multidrug-resistant lung_tumor cells .
24894561	0	rifampicin	78,88	Rv1258c	192,199	rifampicin	Rv1258c	MESH:D012293	887056(Tax:83332)	Chemical	Gene	Synthesis|nmod|START_ENTITY Synthesis|nmod|END_ENTITY	Synthesis of new verapamil analogues and their evaluation in combination with rifampicin against Mycobacterium_tuberculosis and molecular docking studies in the binding site of efflux protein Rv1258c .
10887954	0	rifampicin	43,53	cytochrome_P450	11,26	rifampicin	cytochrome P450	MESH:D012293	100328948(Tax:9986)	Chemical	Gene	Intestinal|nmod|START_ENTITY Intestinal|dobj|END_ENTITY	Intestinal cytochrome_P450 and response to rifampicin in rabbits .
23974699	0	rifampicin	25,35	cytochrome_P450	55,70	rifampicin	cytochrome P450	MESH:D012293	4051	Chemical	Gene	discontinuation|compound|START_ENTITY discontinuation|nmod|activity activity|amod|END_ENTITY	Chronological effects of rifampicin discontinuation on cytochrome_P450 activity in healthy Japanese volunteers , using the cocktail method .
10408915	0	rifampicin	72,82	multidrug_resistance-associated_protein	14,53	rifampicin	multidrug resistance-associated protein	MESH:D012293	8714	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Inhibition of multidrug_resistance-associated_protein -LRB- MRP -RRB- activity by rifampicin in human multidrug-resistant lung_tumor cells .
10570062	0	rifampicin	90,100	pregnane_X_receptor	17,36	rifampicin	pregnane X receptor	MESH:D012293	8856	Chemical	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	The orphan human pregnane_X_receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module .
10772631	0	rifampicin	43,53	pregnane_X_receptor	7,26	rifampicin	pregnane X receptor	MESH:D012293	18171(Tax:10090)	Chemical	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	Rabbit pregnane_X_receptor is activated by rifampicin .
14600250	0	rifampicin	29,39	pregnane_X_receptor	90,109	rifampicin	pregnane X receptor	MESH:D012293	8856	Chemical	Gene	CYP2C9|nmod|START_ENTITY Induction|nmod|CYP2C9 mediated|nsubjpass|Induction mediated|nmod|END_ENTITY	Induction of human CYP2C9 by rifampicin , hyperforin , and phenobarbital is mediated by the pregnane_X_receptor .
924280	0	rifampicin	10,20	tryptophanase	24,37	rifampicin	tryptophanase	MESH:D012293	6999	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|induction induction|amod|END_ENTITY	Effect of rifampicin on tryptophanase induction in normal and rifampicin-resistant Vibrio el tor .
25047139	0	rifampin	10,18	Bcl-2	113,118	rifampin	Bcl-2	MESH:D012293	596	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|inhibitor inhibitor|nmod|END_ENTITY	Effect of rifampin on the pharmacokinetics , safety and tolerability of navitoclax -LRB- ABT-263 -RRB- , a dual inhibitor of Bcl-2 and Bcl-XL , in patients with cancer .
9749821	0	rifampin	10,18	CD1b	22,26	rifampin	CD1b	MESH:D012293	910	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of rifampin on CD1b expression and double-negative T cell responses against mycobacteria-derived glycolipid antigen .
11297522	0	rifampin	75,83	MDR1	67,71	rifampin	MDR1	MESH:D012293	5243	Chemical	Gene	mediate|nmod|START_ENTITY mediate|dobj|induction induction|nmod|END_ENTITY	Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin .
12721332	0	rifampin	84,92	P-glycoprotein	14,28	rifampin	P-glycoprotein	MESH:D012293	67078(Tax:10090)	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|activity activity|amod|END_ENTITY	Modulation of P-glycoprotein transport activity in the mouse blood-brain barrier by rifampin .
23320515	0	rifampin	63,71	PXR	88,91	rifampin	PXR	MESH:D012293	8856	Chemical	Gene	START_ENTITY|appos|activator activator|compound|END_ENTITY	Global metabolomics and targeted steroid profiling reveal that rifampin , a strong human PXR activator , alters endogenous urinary steroid markers .
11744607	0	rifampin	92,100	multidrug_resistance-1	13,35	rifampin	multidrug resistance-1	MESH:D012293	5243	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|mRNAs mRNAs|amod|END_ENTITY	Induction of multidrug_resistance-1 and cytochrome_P450 mRNAs in human mononuclear cells by rifampin .
8289340	0	rifampin	39,47	p65	99,102	rifampin	p65	MESH:D012293	5970	Chemical	Gene	START_ENTITY|nmod|distribution distribution|nmod|END_ENTITY	Assembly of vaccinia_virus : effects of rifampin on the intracellular distribution of viral protein p65 .
26990650	0	riluzole	22,30	spinocerebellar_ataxia_type_3	67,96	riluzole	spinocerebellar ataxia type 3	MESH:D019782	110616(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|drug drug|nmod|END_ENTITY	In vivo assessment of riluzole as a potential therapeutic drug for spinocerebellar_ataxia_type_3 .
10940	0	rimiterol	52,61	beta2-adrenoceptor	18,36	rimiterol	beta2-adrenoceptor	MESH:C084590	154	Chemical	Gene	selectivity|nmod|START_ENTITY selectivity|amod|END_ENTITY	Comparison of the beta2-adrenoceptor selectivity of rimiterol , salbutamol and isoprenaline by the intravenous route in man .
12967941	0	rimonabant	131,141	CB1	20,23	rimonabant	CB1	MESH:C089032	12801(Tax:10090)	Chemical	Gene	Role|appos|START_ENTITY Role|nmod|receptors receptors|compound|END_ENTITY	Role of cannabinoid CB1 receptors and tumor_necrosis_factor-alpha in the gut and systemic anti-inflammatory activity of SR_141716 -LRB- rimonabant -RRB- in rodents .
14694354	0	rimonabant	53,63	CB1	28,31	rimonabant	CB1	MESH:C089032	12801(Tax:10090)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	Blockade by the cannabinoid CB1 receptor antagonist , rimonabant -LRB- SR141716 -RRB- , of the potentiation by quinelorane of food-primed reinstatement of food-seeking behavior .
15167981	0	rimonabant	54,64	CB1	81,84	rimonabant	CB1	MESH:C089032	25248(Tax:10116)	Chemical	Gene	SR-141716|appos|START_ENTITY rats|nmod|SR-141716 effects|nmod|rats effects|appos|antagonist antagonist|nummod|END_ENTITY	Discriminative stimulus effects in rats of SR-141716 -LRB- rimonabant -RRB- , a cannabinoid CB1 receptor antagonist .
15292905	0	rimonabant	164,174	CB1	138,141	rimonabant	CB1	MESH:C089032	25248(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|appos|END_ENTITY	Nicotine-associated cues maintain nicotine-seeking behavior in rats several weeks after nicotine withdrawal : reversal by the cannabinoid -LRB- CB1 -RRB- receptor antagonist , rimonabant -LRB- SR141716 -RRB- .
15691527	0	rimonabant	51,61	CB1	27,30	rimonabant	CB1	MESH:C089032	12801(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|antagonist antagonist|compound|END_ENTITY	Effects of the cannabinoid CB1 receptor antagonist rimonabant in models of emotional reactivity in rodents .
16148441	0	rimonabant	157,167	CB1	122,125	rimonabant	CB1	MESH:C089032	25248(Tax:10116)	Chemical	Gene	SR-141716|appos|START_ENTITY SR-141716|compound|END_ENTITY	Delta9-THC induced hyperphagia and tolerance assessment : interactions between the CB1 receptor agonist delta9-THC and the CB1 receptor antagonist SR-141716 -LRB- rimonabant -RRB- in rats .
16412990	0	rimonabant	11,21	CB1	47,50	rimonabant	CB1	MESH:C089032	25248(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Effects of rimonabant , a selective cannabinoid CB1 receptor antagonist , in a rat model of Parkinson 's _ disease .
16814374	0	rimonabant	46,56	CB1	16,19	rimonabant	CB1	MESH:C089032	25248(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	The cannabinoid CB1 receptor inverse agonist , rimonabant , modifies body weight and adiponectin function in diet-induced obese rats as a consequence of reduced food intake .
16958983	0	rimonabant	12,22	CB1	45,48	rimonabant	CB1	MESH:C089032	1268	Chemical	Gene	Efficacy|nmod|START_ENTITY cannabinoid|nsubj|Efficacy cannabinoid|dobj|antagonists antagonists|nummod|END_ENTITY	Efficacy of rimonabant and other cannabinoid CB1 receptor antagonists in reducing food intake and body weight : preclinical and clinical data .
17220538	0	rimonabant	71,81	CB1	27,30	rimonabant	CB1	MESH:C089032	25248(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY Involvement|dep|effects Involvement|nmod|receptors receptors|compound|END_ENTITY	Involvement of cannabinoid CB1 receptors in drug_addiction : effects of rimonabant on behavioral responses induced by cocaine .
17245360	0	rimonabant	50,60	CB1	26,29	rimonabant	CB1	MESH:C089032	25248(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|antagonist antagonist|compound|END_ENTITY	Effect of the cannabinoid CB1 receptor antagonist rimonabant on nociceptive responses and adjuvant-induced arthritis in obese and lean rats .
17387457	0	rimonabant	51,61	CB1	27,30	rimonabant	CB1	MESH:C089032	25248(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|antagonist antagonist|compound|END_ENTITY	Effects of the cannabinoid CB1 receptor antagonist rimonabant on distinct measures of impulsive behavior in rats .
17952655	0	rimonabant	41,51	CB1	16,19	rimonabant	CB1	MESH:C089032	25248(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	The cannabinoid CB1 receptor antagonist , rimonabant , as a promising pharmacotherapy for alcohol_dependence : preclinical evidence .
17989514	0	rimonabant	126,136	CB1	51,54	rimonabant	CB1	MESH:C089032	25248(Tax:10116)	Chemical	Gene	prevented|nmod|START_ENTITY switch|acl:relcl|prevented switch|compound|END_ENTITY	Cannabinoid-induced tolerance is associated with a CB1 receptor G protein coupling switch that is prevented by ultra-low dose rimonabant .
18059061	0	rimonabant	80,90	CB1	94,97	rimonabant	CB1	MESH:C089032	1268	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Liquid chromatography tandem mass spectrometry method for the quantification of rimonabant , a CB1 receptor antagonist , in human plasma .
18253160	0	rimonabant	11,21	CB1	37,40	rimonabant	CB1	MESH:C089032	25248(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|receptor receptor|compound|END_ENTITY	Effects of rimonabant , a cannabinoid CB1 receptor ligand , on energy expenditure in lean rats .
18264696	0	rimonabant	75,85	CB1	51,54	rimonabant	CB1	MESH:C089032	25248(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|antagonist antagonist|compound|END_ENTITY	Discriminative stimulus effects of the cannabinoid CB1 receptor antagonist rimonabant in rats .
18342403	0	rimonabant	144,154	CB1	94,97	rimonabant	CB1	MESH:C089032	1268	Chemical	Gene	related|xcomp|START_ENTITY related|nsubj|design design|appos|evaluation evaluation|nmod|derivatives derivatives|nmod|antagonists antagonists|compound|END_ENTITY	Rational design , synthesis and biological evaluation of new 1,5-diarylpyrazole derivatives as CB1 receptor antagonists , structurally related to rimonabant .
18417461	0	rimonabant	38,48	CB1	20,23	rimonabant	CB1	MESH:C089032	1268	Chemical	Gene	blockade|nmod|START_ENTITY blockade|nummod|END_ENTITY	Long-term effect of CB1 blockade with rimonabant on cardiometabolic risk factors : two year results from the RIO-Europe Study .
18426513	0	rimonabant	105,115	CB1	0,3	rimonabant	CB1	MESH:C089032	1268	Chemical	Gene	programme|nmod|START_ENTITY overview|nmod|programme blockade|dep|overview blockade|compound|END_ENTITY	CB1 receptor blockade and its impact on cardiometabolic risk factors : overview of the RIO programme with rimonabant .
18678611	0	rimonabant	112,122	CB1	144,147	rimonabant	CB1	MESH:C089032	1268	Chemical	Gene	monotherapy|nmod|START_ENTITY effects|nmod|monotherapy SERENADE|dep|effects SERENADE|appos|antagonist antagonist|compound|END_ENTITY	SERENADE : the Study Evaluating Rimonabant Efficacy in Drug-naive Diabetic Patients : effects of monotherapy with rimonabant , the first selective CB1 receptor antagonist , on glycemic control , body weight , and lipid profile in drug-naive type 2 diabetes .
18814765	0	rimonabant	57,67	CB1	1,4	rimonabant	CB1	MESH:C089032	1268	Chemical	Gene	role|nmod|START_ENTITY inhibition|dep|role inhibition|nummod|END_ENTITY	-LSB- CB1 receptor inhibition and glucose metabolism : role of rimonabant in type 2 diabetes -RSB- .
19325539	4	rimonabant	573,583	CB1	476,479	rimonabant	CB1	MESH:C089032	25248(Tax:10116)	Chemical	Gene	received|dobj|START_ENTITY received|advcl|assess assess|dobj|actions actions|nmod|antagonism antagonism|compound|END_ENTITY	In order to assess the actions of CB1 antagonism on glucose homeostasis , diet-induced obese -LRB- DIO -RRB- rats received the CB1 antagonist rimonabant -LRB- 10 mg/kg , intraperitoneally -LRB- IP -RRB- -RRB- or its vehicle for 4 weeks , or were pair-fed to the rimonabant-treated group for the same length of time .
19462153	0	rimonabant	41,51	CB1	16,19	rimonabant	CB1	MESH:C089032	12801(Tax:10090)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	The cannabinoid CB1 receptor antagonist , rimonabant , protects against acute_myocardial_infarction .
19956878	0	rimonabant	100,110	CB1	76,79	rimonabant	CB1	MESH:C089032	1268	Chemical	Gene	antagonist|dobj|START_ENTITY antagonist|nsubj|inhibition inhibition|nmod|growth growth|nmod|receptor receptor|compound|END_ENTITY	Synergistic inhibition of human colon_cancer cell growth by the cannabinoid CB1 receptor antagonist rimonabant and oxaliplatin .
20406631	0	rimonabant	10,20	CB1	38,41	rimonabant	CB1	MESH:C089032	25248(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Effect of rimonabant , the cannabinoid CB1 receptor antagonist , on peripheral nerve in streptozotocin-induced diabetic rat .
21369753	0	rimonabant	144,154	CB1	120,123	rimonabant	CB1	MESH:C089032	25248(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|mediation mediation|nmod|cannabinergics cannabinergics|nmod|effects effects|nmod|antagonist antagonist|compound|END_ENTITY	Central mediation and differential blockade by cannabinergics of the discriminative stimulus effects of the cannabinoid CB1 receptor antagonist rimonabant in rats .
21470203	0	rimonabant	41,51	CB1	16,19	rimonabant	CB1	MESH:C089032	373759(Tax:8355)	Chemical	Gene	antagonists|dobj|START_ENTITY antagonists|nsubj|receptor receptor|compound|END_ENTITY	The cannabinoid CB1 receptor antagonists rimonabant -LRB- SR141716 -RRB- and AM251 directly potentiate GABA -LRB- A -RRB- receptors .
22093909	0	rimonabant	30,40	CB1	100,103	rimonabant	CB1	MESH:C089032	1268	Chemical	Gene	effect|nmod|START_ENTITY mediated|nsubjpass|effect mediated|nmod|receptor receptor|compound|END_ENTITY	The inverse agonist effect of rimonabant on G protein activation is not mediated by the cannabinoid CB1 receptor : evidence from postmortem human brain .
23487769	4	rimonabant	829,839	CB1	724,727	rimonabant	CB1	MESH:C089032	12801(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY dispensable|nmod|effects dispensable|nsubj|receptor receptor|nummod|END_ENTITY	Fasting/refeeding experiments revealed that CB1 receptor signaling in many specific brain neurons is dispensable for the acute hypophagic effects of rimonabant .
21406493	0	rimonabant	80,90	cannabinoid_type_1_receptor	40,67	rimonabant	cannabinoid type 1 receptor	MESH:C089032	1268	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	Effects of 7 days of treatment with the cannabinoid_type_1_receptor antagonist , rimonabant , on emotional processing .
20807320	0	rimonabant	54,64	growth_hormone	68,82	rimonabant	growth hormone	MESH:C089032	2688	Chemical	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	Peripheral endocannabinoid system-mediated actions of rimonabant on growth_hormone secretion are ghrelin-dependent .
21627558	0	risedronate	14,25	osteoprotegerin	45,60	risedronate	osteoprotegerin	MESH:C073008	4982	Chemical	Gene	treatment|amod|START_ENTITY effect|nmod|treatment effect|nmod|END_ENTITY	The effect of risedronate treatment on serum osteoprotegerin and bone marker levels in postmenopausal women with osteoporosis .
24120669	0	risedronate	65,76	progranulin	46,57	risedronate	progranulin	MESH:C073008	2896	Chemical	Gene	treatment|amod|START_ENTITY END_ENTITY|nmod|treatment	Osteoblastic cell secretome : a novel role for progranulin during risedronate treatment .
22623266	0	risperidone	39,50	CYP2D6	106,112	risperidone	CYP2D6	MESH:D018967	1565	Chemical	Gene	analysis|nmod|START_ENTITY analysis|nmod|END_ENTITY	Population pharmacokinetic analysis of risperidone and 9-hydroxyrisperidone with genetic polymorphisms of CYP2D6 and ABCB1 .
19329549	0	risperidone	14,25	D-amino_acid_oxidase	29,49	risperidone	D-amino acid oxidase	MESH:D018967	1610	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|amod|END_ENTITY	The effect of risperidone on D-amino_acid_oxidase activity as a hypothesis for a novel mechanism of action in the treatment of schizophrenia .
14610521	0	risperidone	68,79	DRD2	10,14	risperidone	DRD2	MESH:D018967	1813	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of DRD2 , 5-HT2A , and COMT genes on antipsychotic response to risperidone .
17059881	0	risperidone	34,45	Dopamine_D2_receptor	0,20	risperidone	Dopamine D2 receptor	MESH:D018967	1813	Chemical	Gene	occupancy|nmod|START_ENTITY occupancy|amod|END_ENTITY	Dopamine_D2_receptor occupancy by risperidone : implications for the timing and magnitude of clinical response .
22230651	0	risperidone	36,47	Dopamine_D2_receptor	0,20	risperidone	Dopamine D2 receptor	MESH:D018967	1813	Chemical	Gene	occupancy|nmod|START_ENTITY occupancy|amod|END_ENTITY	Dopamine_D2_receptor occupancy with risperidone or olanzapine during maintenance treatment of schizophrenia : a cross-sectional study .
7508329	0	risperidone	77,88	Dopamine_D2_receptor	0,20	risperidone	Dopamine D2 receptor	MESH:D018967	1813	Chemical	Gene	occupancy|nmod|START_ENTITY occupancy|amod|END_ENTITY	Dopamine_D2_receptor occupancy in vivo and response to the new antipsychotic risperidone .
21652606	0	risperidone	27,38	HRH3	70,74	risperidone	HRH3	MESH:D018967	11255	Chemical	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	A pharmacogenetic study of risperidone on histamine_H3_receptor gene -LRB- HRH3 -RRB- in Chinese Han schizophrenia patients .
20304506	0	risperidone	51,62	Homer1a	27,34	risperidone	Homer1a	MESH:D018967	9456	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Haloperidol induces higher Homer1a expression than risperidone , olanzapine and sulpiride in striatal sub-regions .
19042107	0	risperidone	9,20	NCAM	59,63	risperidone	NCAM	MESH:D018967	24586(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY increases|nsubj|treatment increases|dobj|expression expression|nmod|END_ENTITY	Repeated risperidone treatment increases the expression of NCAM and PSA-NCAM protein in the rat medial prefrontal cortex .
16118767	0	risperidone	32,43	P-glycoprotein	0,14	risperidone	P-glycoprotein	MESH:D018967	67078(Tax:10090)	Chemical	Gene	interaction|nmod|START_ENTITY interaction|amod|END_ENTITY	P-glycoprotein interaction with risperidone and 9-OH-risperidone studied in vitro , in knock-out mice and in drug-drug interaction experiments .
11838821	0	risperidone	81,92	Prolactin	0,9	risperidone	Prolactin	MESH:D018967	5617	Chemical	Gene	treatment|amod|START_ENTITY pervasive_developmental_disorders|nmod|treatment levels|nmod|pervasive_developmental_disorders levels|compound|END_ENTITY	Prolactin levels in young children with pervasive_developmental_disorders during risperidone treatment .
12686750	0	risperidone	82,93	Prolactin	0,9	risperidone	Prolactin	MESH:D018967	5617	Chemical	Gene	receiving|advcl|START_ENTITY levels|acl|receiving levels|compound|END_ENTITY	Prolactin levels in schizophrenic patients receiving perospirone in comparison to risperidone .
14658952	0	risperidone	34,45	Prolactin	0,9	risperidone	Prolactin	MESH:D018967	5617	Chemical	Gene	treatment|compound|START_ENTITY levels|nmod|treatment levels|compound|END_ENTITY	Prolactin levels during long-term risperidone treatment in children and adolescents .
15206663	0	risperidone	64,75	Prolactin	0,9	risperidone	Prolactin	MESH:D018967	5617	Chemical	Gene	treated|nmod|START_ENTITY patients|acl|treated function|nmod|patients function|nsubj|levels levels|compound|END_ENTITY	Prolactin levels and erectile function in patients treated with risperidone .
15289996	0	risperidone	61,72	Prolactin	0,9	risperidone	Prolactin	MESH:D018967	5617	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|levels levels|compound|END_ENTITY	Prolactin levels in male schizophrenic patients treated with risperidone and haloperidol : a double-blind and randomized study .
16526181	0	risperidone	104,115	Prolactin	1,10	risperidone	Prolactin	MESH:D018967	5617	Chemical	Gene	disturbances|dep|START_ENTITY disturbances|compound|END_ENTITY	-LSB- Prolactin secretion disturbances in schizophrenic patients treated with 2nd generation antipsychotics -- risperidone and olanzapine -RSB- .
17094165	0	risperidone	41,52	Prolactin	0,9	risperidone	Prolactin	MESH:D018967	5617	Chemical	Gene	elevation|nmod|START_ENTITY elevation|compound|END_ENTITY	Prolactin elevation of the antipsychotic risperidone is predominantly related to its 9-hydroxy metabolite .
17224713	0	risperidone	43,54	Prolactin	0,9	risperidone	Prolactin	MESH:D018967	5617	Chemical	Gene	treated|nmod|START_ENTITY children|acl|treated release|nmod|children release|compound|END_ENTITY	Prolactin release in children treated with risperidone : impact and role of CYP2D6 metabolism .
17355517	0	risperidone	34,45	Prolactin	0,9	risperidone	Prolactin	MESH:D018967	5617	Chemical	Gene	treatment|amod|START_ENTITY years|nmod|treatment level|nmod|years level|nsubj|END_ENTITY	Prolactin level during 5 years of risperidone treatment in patients with psychotic_disorders .
17519641	0	risperidone	95,106	Prolactin	0,9	risperidone	Prolactin	MESH:D018967	5617	Chemical	Gene	treated|nmod|START_ENTITY patients|acl|treated nonparanoid|dobj|patients nonparanoid|nsubj|levels levels|amod|END_ENTITY	Prolactin serum levels in paranoid versus nonparanoid male schizophrenia patients treated with risperidone .
18466271	0	risperidone	117,128	Prolactin	0,9	risperidone	Prolactin	MESH:D018967	5617	Chemical	Gene	comparing|nmod|START_ENTITY study|acl|comparing END_ENTITY|dep|study	Prolactin , subjective well-being and sexual_dysfunction : an open label observational study comparing quetiapine with risperidone .
9934944	0	risperidone	61,72	Prolactin	0,9	risperidone	Prolactin	MESH:D018967	5617	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|levels levels|compound|END_ENTITY	Prolactin levels and adverse events in patients treated with risperidone .
19270464	0	risperidone	131,142	brain-derived_neurotropic_factor	17,49	risperidone	brain-derived neurotropic factor	MESH:D018967	627	Chemical	Gene	response|acl|START_ENTITY END_ENTITY|nmod|response	Increased plasma brain-derived_neurotropic_factor , not nerve growth factor-Beta , in schizophrenia patients with better response to risperidone treatment .
18937879	0	risperidone	101,112	dopamine_D2_receptor	26,46	risperidone	dopamine D2 receptor	MESH:D018967	1813	Chemical	Gene	occupancy|nmod|START_ENTITY occupancy|amod|END_ENTITY	No regional difference in dopamine_D2_receptor occupancy by the second-generation antipsychotic drug risperidone in humans : a positron emission tomography study .
21652606	0	risperidone	27,38	histamine_H3_receptor	42,63	risperidone	histamine H3 receptor	MESH:D018967	11255	Chemical	Gene	START_ENTITY|nmod|gene gene|amod|END_ENTITY	A pharmacogenetic study of risperidone on histamine_H3_receptor gene -LRB- HRH3 -RRB- in Chinese Han schizophrenia patients .
19914297	0	risperidone	28,39	parvalbumin	128,139	risperidone	parvalbumin	MESH:D018967	25269(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|acl|END_ENTITY	Effect of pretreatment with risperidone on phencyclidine-induced disruptions in object recognition memory and prefrontal cortex parvalbumin immunoreactivity in the rat .
12019665	0	risperidone	93,104	prolactin	25,34	risperidone	prolactin	MESH:D018967	5617	Chemical	Gene	treated|nmod|START_ENTITY Effects|acl|treated Effects|nmod|levels levels|compound|END_ENTITY	Effects of olanzapine on prolactin levels of female patients with schizophrenia treated with risperidone .
1380082	0	risperidone	15,26	prolactin	34,43	risperidone	prolactin	MESH:D018967	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Stimulation by risperidone of rat prolactin secretion in vivo and in cultured pituitary cells in vitro .
15863810	0	risperidone	48,59	prolactin	79,88	risperidone	prolactin	MESH:D018967	5617	Chemical	Gene	metabolite|nmod|START_ENTITY role|nmod|metabolite role|nmod|levels levels|compound|END_ENTITY	Predominant role of the 9-hydroxy metabolite of risperidone in elevating blood prolactin levels .
16379509	0	risperidone	54,65	prolactin	9,18	risperidone	prolactin	MESH:D018967	5617	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|levels levels|compound|END_ENTITY	Elevated prolactin levels in male youths treated with risperidone and quetiapine .
16466670	0	risperidone	69,80	prolactin	25,34	risperidone	prolactin	MESH:D018967	5617	Chemical	Gene	relationship|nmod|START_ENTITY relationship|nmod|response response|compound|END_ENTITY	The relationship between prolactin response and clinical efficacy of risperidone in acute psychotic inpatients .
17454518	0	risperidone	176,187	prolactin	31,40	risperidone	prolactin	MESH:D018967	5617	Chemical	Gene	trial|nmod|START_ENTITY relationship|dep|trial relationship|nmod|level level|compound|END_ENTITY	The relationship between serum prolactin level and sexual functioning among male outpatients with schizophrenia or schizoaffective_disorder : a randomized double-blind trial of risperidone vs. quetiapine .
17715206	0	risperidone	31,42	prolactin	6,15	risperidone	prolactin	MESH:D018967	5617	Chemical	Gene	levels|compound|START_ENTITY levels|appos|levels levels|compound|END_ENTITY	Serum prolactin levels , plasma risperidone levels , polymorphism of cytochrome_P450_2D6 and clinical response in patients with schizophrenia .
19038534	0	risperidone	103,114	prolactin	27,36	risperidone	prolactin	MESH:D018967	5617	Chemical	Gene	cross-titration|nmod|START_ENTITY schizophrenia|nmod|cross-titration subjects|nmod|schizophrenia levels|nmod|subjects levels|compound|END_ENTITY	Effects of aripiprazole on prolactin levels in subjects with schizophrenia during cross-titration with risperidone or olanzapine : analysis of a randomized , open-label study .
19706318	0	risperidone	45,56	prolactin	32,41	risperidone	prolactin	MESH:D018967	5617	Chemical	Gene	treatments|amod|START_ENTITY -|nmod|treatments -|nmod|END_ENTITY	Short - and long-term effects on prolactin of risperidone and olanzapine treatments in children and adolescents .
20170699	0	risperidone	68,79	prolactin	16,25	risperidone	prolactin	MESH:D018967	5617	Chemical	Gene	treatments|nmod|START_ENTITY response|nmod|treatments response|compound|END_ENTITY	Gender-specific prolactin response to antipsychotic treatments with risperidone and olanzapine and its relationship to drug concentrations in patients with acutely exacerbated schizophrenia .
20621147	0	risperidone	51,62	prolactin	89,98	risperidone	prolactin	MESH:D018967	5617	Chemical	Gene	metabolism|amod|START_ENTITY relationship|nmod|metabolism differences|nmod|relationship END_ENTITY|nsubj|differences	Gender differences in the relationship between the risperidone metabolism and the plasma prolactin levels in psychiatric patients .
23232756	0	risperidone	120,131	prolactin	11,20	risperidone	prolactin	MESH:D018967	5617	Chemical	Gene	START_ENTITY|nsubj|Changes Changes|nmod|levels levels|compound|END_ENTITY	Changes in prolactin levels and sexual function in young psychotic patients after switching from long-acting injectable risperidone to paliperidone_palmitate .
25092954	0	risperidone	164,175	prolactin	55,64	risperidone	prolactin	MESH:D018967	5617	Chemical	Gene	comparing|nmod|START_ENTITY comparing|dobj|changes changes|nmod|END_ENTITY	Randomized controlled trial comparing changes in serum prolactin and weight among female patients with first-episode schizophrenia over 12 months of treatment with risperidone or quetiapine .
26976681	0	risperidone	84,95	prolactin	6,15	risperidone	prolactin	MESH:D018967	5617	Chemical	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	Serum prolactin levels and sexual_dysfunctions in antipsychotic medication , such as risperidone : a review .
12640213	0	risperidone	14,25	superoxide_dismutase	39,59	risperidone	superoxide dismutase	MESH:D018967	6647	Chemical	Gene	treatment|amod|START_ENTITY effect|nmod|treatment effect|nmod|END_ENTITY	The effect of risperidone treatment on superoxide_dismutase in schizophrenia .
10929042	6	ristocetin	819,829	VWF	873,876	ristocetin	VWF	MESH:D012310	7450	Chemical	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Removal of A antigen with alpha-N-acetylgalactosaminidase or B antigen with alpha-galactosidase did not affect its multimer size or antigenic level , but decreased the ristocetin cofactor -LRB- RCoF -RRB- activity of the respective VWF by 33-39 % -LRB- P < 0.01-0 .002 -RRB- .
6983351	0	ristocetin	34,44	von_Willebrand_factor	72,93	ristocetin	von Willebrand factor	MESH:D012310	7450	Chemical	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Amino group modification inhibits ristocetin cofactor activity of human von_Willebrand_factor .
10986089	0	ristocetin_A	58,70	DEF	39,42	ristocetin A	DEF	MESH:C016719	27042	Chemical	Gene	system|nmod|START_ENTITY system|compound|END_ENTITY	Approaches to the fully functionalized DEF ring system of ristocetin_A via highly selective ruthenium-promoted S -LRB- N -RRB- Ar reaction .
2892349	0	ritanserin	35,45	5-HT2-receptor	8,22	ritanserin	5-HT2-receptor	MESH:D016713	3356	Chemical	Gene	blockade|nmod|START_ENTITY blockade|amod|END_ENTITY	Chronic 5-HT2-receptor blockade by ritanserin does not reduce blood pressure in patients with essential hypertension .
1343870	0	ritanserin	10,20	5-HT2_receptor	41,55	ritanserin	5-HT2 receptor	MESH:D016713	3356	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Effect of ritanserin , a highly selective 5-HT2_receptor antagonist , on Parkinson 's _ disease .
1903019	0	ritanserin	94,104	5-HT2_receptor	0,14	ritanserin	5-HT2 receptor	MESH:D016713	3356	Chemical	Gene	study|nmod|START_ENTITY antagonism|dep|study antagonism|amod|END_ENTITY	5-HT2_receptor antagonism in dysthymic_disorder : a double-blind placebo-controlled study with ritanserin .
1851310	0	ritanserin	21,31	ACTH	78,82	ritanserin	ACTH	MESH:D016713	5443	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Inhibitory effect of ritanserin on the 5-hydroxytryptophan-mediated cortisol , ACTH and prolactin secretion in humans .
16364460	0	ritanserin	18,28	CA1	38,41	ritanserin	CA1	MESH:D016713	310218(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|region region|compound|END_ENTITY	Microinjection of ritanserin into the CA1 region of hippocampus improves scopolamine-induced amnesia in adult male rats .
7993659	0	ritodrine	48,57	Erythropoietin	0,14	ritodrine	Erythropoietin	MESH:D012312	24335(Tax:10116)	Chemical	Gene	administration|amod|START_ENTITY END_ENTITY|nmod|administration	Erythropoietin -LRB- EPO -RRB- levels in fetal rats after ritodrine and terbutaline administration .
23886699	0	ritonavir	14,23	CYP2B6	33,39	ritonavir	CYP2B6	MESH:D019438	1555	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	The effect of ritonavir on human CYP2B6 catalytic activity : heme modification contributes to the mechanism-based inactivation of CYP2B6 and CYP3A4 by ritonavir .
15492266	0	ritonavir	26,35	CYP3A4	59,65	ritonavir	CYP3A4	MESH:D019438	1576	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	HIV-1 protease inhibitor , ritonavir : a potent inhibitor of CYP3A4 , enhanced the anticancer effects of docetaxel in androgen-independent prostate_cancer cells in vitro and in vivo .
20201776	0	ritonavir	10,19	CYP3A4	61,67	ritonavir	CYP3A4	MESH:D019438	1576	Chemical	Gene	Impact|nmod|START_ENTITY Impact|nmod|potential potential|compound|END_ENTITY	Impact of ritonavir , atazanavir and their combination on the CYP3A4 induction potential of efavirenz in primary human hepatocytes .
23381882	0	ritonavir	50,59	CYP3A4	118,124	ritonavir	CYP3A4	MESH:D019438	1576	Chemical	Gene	enhancement|nmod|START_ENTITY Mechanisms|nmod|enhancement Mechanisms|dep|tests tests|appos|END_ENTITY	Mechanisms of pharmacokinetic enhancement between ritonavir and saquinavir ; micro/small dosing tests using midazolam -LRB- CYP3A4 -RRB- , fexofenadine -LRB- p-glycoprotein -RRB- , and pravastatin -LRB- OATP1B1 -RRB- as probe drugs .
12501133	0	ritonavir	134,143	MDR-1	96,101	ritonavir	MDR-1	MESH:D019438	5243	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Intracellular concentration of protease inhibitors in HIV-1-infected patients : correlation with MDR-1 gene expression and low dose of ritonavir .
12218384	0	ritonavir	23,32	MRP-1	113,118	ritonavir	MRP-1	MESH:D019438	4363	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	The protease inhibitor ritonavir inhibits the functional activity of the multidrug_resistance_related-protein_1 -LRB- MRP-1 -RRB- .
11230802	0	ritonavir	23,32	P-glycoprotein	61,75	ritonavir	P-glycoprotein	MESH:D019438	5243	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	HIV protease inhibitor ritonavir : a more potent inhibitor of P-glycoprotein than the cyclosporine analog SDZ_PSC_833 .
11259625	0	ritonavir	108,117	P-glycoprotein	0,14	ritonavir	P-glycoprotein	MESH:D019438	5243	Chemical	Gene	doses|nmod|START_ENTITY limits|nmod|doses limits|nsubj|END_ENTITY	P-glycoprotein limits oral availability , brain , and fetal penetration of saquinavir even with high doses of ritonavir .
21212519	0	ritonavir	49,58	P-glycoprotein	107,121	ritonavir	P-glycoprotein	MESH:D019438	287115(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY Evidence|nmod|levels Evidence|nmod|inhibition inhibition|amod|END_ENTITY	Evidence for time-dependent interactions between ritonavir and lopinavir/ritonavir plasma levels following P-glycoprotein inhibition in Sprague-Dawley_rats .
23589366	0	ritonavir	30,39	P-glycoprotein	110,124	ritonavir	P-glycoprotein	MESH:D019438	287115(Tax:10116)	Chemical	Gene	interaction|nmod|START_ENTITY interaction|dep|balance balance|nmod|3A 3A|amod|END_ENTITY	Time-dependent interaction of ritonavir in chronic use : the power balance between inhibition and induction of P-glycoprotein and cytochrome P450 3A .
20551242	0	ritonavir	102,111	p-glycoprotein	84,98	ritonavir	p-glycoprotein	MESH:D019438	67078(Tax:10090)	Chemical	Gene	demonstrates|nmod|START_ENTITY demonstrates|dobj|inhibition inhibition|nmod|END_ENTITY	In situ intestinal perfusion in knockout mice demonstrates inhibition of intestinal p-glycoprotein by ritonavir causing increased darunavir absorption .
22851565	0	rituximab	84,93	MYC	25,28	rituximab	MYC	CHEBI:64357	4609	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|expression expression|nmod|END_ENTITY	Concurrent expression of MYC and BCL2 in diffuse large B-cell_lymphoma treated with rituximab plus cyclophosphamide , doxorubicin , vincristine , and prednisone .
21360491	0	rituximab	28,37	tumor_necrosis_factor	60,81	rituximab	tumor necrosis factor	CHEBI:64357	7124	Chemical	Gene	START_ENTITY|nmod|combination combination|nmod|inhibitor inhibitor|compound|END_ENTITY	Evaluation of the safety of rituximab in combination with a tumor_necrosis_factor inhibitor and methotrexate in patients with active rheumatoid_arthritis : results from a randomized controlled trial .
25849716	0	rivabirin	91,100	IFNa	80,84	rivabirin	IFNa	null	3438	Chemical	Gene	therapy|compound|START_ENTITY therapy|compound|END_ENTITY	Inherent transcriptional signatures of NK cells are associated with response to IFNa + rivabirin therapy in patients with Hepatitis_C Virus .
17116766	0	rivaroxaban	48,59	Factor_Xa	27,36	rivaroxaban	Factor Xa	MESH:C503223	2159	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	A once-daily , oral , direct Factor_Xa inhibitor , rivaroxaban -LRB- BAY_59-7939 -RRB- , for thromboprophylaxis after total hip replacement .
17292948	0	rivaroxaban	25,36	Factor_Xa	68,77	rivaroxaban	Factor Xa	MESH:C503223	2159	Chemical	Gene	study|nmod|START_ENTITY study|dep|inhibitor inhibitor|compound|END_ENTITY	Dose-escalation study of rivaroxaban -LRB- BAY_59-7939 -RRB- -- an oral , direct Factor_Xa inhibitor -- for the prevention of venous_thromboembolism in patients undergoing total hip replacement .
17576867	0	rivaroxaban	84,95	Factor_Xa	138,147	rivaroxaban	Factor Xa	MESH:C503223	2159	Chemical	Gene	deep-vein_thrombosis|nmod|START_ENTITY Treatment|nmod|deep-vein_thrombosis Treatment|dep|ODIXa-DVT ODIXa-DVT|dep|BAY_59-7939 BAY_59-7939|compound|END_ENTITY	Treatment of proximal deep-vein_thrombosis with the oral direct factor_Xa inhibitor rivaroxaban -LRB- BAY_59-7939 -RRB- : the ODIXa-DVT -LRB- Oral Direct Factor_Xa Inhibitor BAY_59-7939 in Patients With Acute Symptomatic Deep-Vein_Thrombosis -RRB- study .
18675600	0	rivaroxaban	17,28	Factor_Xa	52,61	rivaroxaban	Factor Xa	MESH:C503223	2159	Chemical	Gene	Determination|nmod|START_ENTITY Determination|dep|novel novel|appos|inhibitor inhibitor|compound|END_ENTITY	Determination of rivaroxaban -- a novel , oral , direct Factor_Xa inhibitor -- in human plasma by high-performance liquid chromatography-tandem mass spectrometry .
20888031	0	rivaroxaban	27,38	Factor_Xa	56,65	rivaroxaban	Factor Xa	MESH:C503223	2159	Chemical	Gene	action|nmod|START_ENTITY mechanism|nmod|action mechanism|dep|inhibitor inhibitor|compound|END_ENTITY	The mechanism of action of rivaroxaban -- an oral , direct Factor_Xa inhibitor -- compared with other anticoagulants .
21039764	0	rivaroxaban	84,95	Factor_Xa	113,122	rivaroxaban	Factor Xa	MESH:C503223	2159	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Effects of renal_impairment on the pharmacokinetics , pharmacodynamics and safety of rivaroxaban , an oral , direct Factor_Xa inhibitor .
22035050	0	rivaroxaban	111,122	Factor_Xa	27,36	rivaroxaban	Factor Xa	MESH:C503223	2159	Chemical	Gene	effect|nmod|START_ENTITY comparing|dobj|effect study|acl|comparing effect|dep|study effect|nmod|inhibitor inhibitor|compound|END_ENTITY	The effect of a new direct Factor_Xa inhibitor on human osteoblasts : an in-vitro study comparing the effect of rivaroxaban with enoxaparin .
23294275	0	rivaroxaban	94,105	Factor_Xa	123,132	rivaroxaban	Factor Xa	MESH:C503223	2159	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Effect of hepatic_impairment on the pharmacokinetics and pharmacodynamics of a single dose of rivaroxaban , an oral , direct Factor_Xa inhibitor .
23381840	0	rivaroxaban	80,91	Factor_Xa	109,118	rivaroxaban	Factor Xa	MESH:C503223	2159	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY influence|nmod|pharmacokinetics influence|dep|inhibitor inhibitor|compound|END_ENTITY	The influence of age and gender on the pharmacokinetics and pharmacodynamics of rivaroxaban -- an oral , direct Factor_Xa inhibitor .
23391196	0	rivaroxaban	26,37	Factor_Xa	183,192	rivaroxaban	Factor Xa	MESH:C503223	2159	Chemical	Gene	discontinuing|dobj|START_ENTITY discontinuing|advcl|warfarin warfarin|dep|Inhibition Inhibition|compound|END_ENTITY	Outcomes of discontinuing rivaroxaban compared with warfarin in patients with nonvalvular atrial_fibrillation : analysis from the ROCKET AF trial -LRB- Rivaroxaban Once-Daily , Oral , Direct Factor_Xa Inhibition Compared With Vitamin_K Antagonism for Prevention of Stroke and Embolism Trial in Atrial_Fibrillation -RRB- .
23631182	0	rivaroxaban	22,33	Factor_Xa	1,10	rivaroxaban	Factor Xa	MESH:C503223	2159	Chemical	Gene	inhibitor|dep|START_ENTITY inhibitor|compound|END_ENTITY	-LSB- Factor_Xa inhibitor -LRB- rivaroxaban and drugs under investigation -RRB- -RSB- .
24895454	0	rivaroxaban	23,34	Factor_Xa	162,171	rivaroxaban	Factor Xa	MESH:C503223	2159	Chemical	Gene	Efficacy|nmod|START_ENTITY Efficacy|nmod|Inhibition Inhibition|compound|END_ENTITY	Efficacy and safety of rivaroxaban compared with warfarin among elderly patients with nonvalvular atrial_fibrillation in the Rivaroxaban Once Daily , Oral , Direct Factor_Xa Inhibition Compared With Vitamin_K Antagonism for Prevention of Stroke and Embolism Trial in Atrial_Fibrillation -LRB- ROCKET AF -RRB- .
26386791	0	rivaroxaban	23,34	Factor_Xa	139,148	rivaroxaban	Factor Xa	MESH:C503223	2159	Chemical	Gene	Efficacy|nmod|START_ENTITY Efficacy|dep|Inhibition Inhibition|compound|END_ENTITY	Efficacy and safety of rivaroxaban in patients with diabetes and nonvalvular atrial_fibrillation : The Rivaroxaban Once-daily , Oral , Direct Factor_Xa Inhibition Compared with Vitamin_K Antagonism for Prevention of Stroke and Embolism Trial in Atrial_Fibrillation -LRB- ROCKET AF Trial -RRB- .
16638738	0	rivaroxaban	95,106	factor_Xa	125,134	rivaroxaban	factor Xa	MESH:C503223	2159	Chemical	Gene	absorption|appos|START_ENTITY absorption|appos|inhibitor inhibitor|compound|END_ENTITY	Effect of food , an antacid , and the H2 antagonist ranitidine on the absorption of BAY_59-7939 -LRB- rivaroxaban -RRB- , an oral , direct factor_Xa inhibitor , in healthy subjects .
16920892	0	rivaroxaban	64,75	factor_Xa	93,102	rivaroxaban	factor Xa	MESH:C503223	2159	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY pharmacokinetics|dep|inhibitor inhibitor|compound|END_ENTITY	Safety , tolerability , pharmacodynamics , and pharmacokinetics of rivaroxaban -- an oral , direct factor_Xa inhibitor -- are not affected by aspirin .
17629849	0	rivaroxaban	44,55	factor_Xa	79,88	rivaroxaban	factor Xa	MESH:C503223	2159	Chemical	Gene	characteristics|nmod|START_ENTITY characteristics|dep|inhibitor inhibitor|compound|END_ENTITY	Preclinical and clinical characteristics of rivaroxaban : a novel , oral , direct factor_Xa inhibitor .
19196846	0	rivaroxaban	23,34	factor_Xa	52,61	rivaroxaban	factor Xa	MESH:C503223	2159	Chemical	Gene	metabolism|nmod|START_ENTITY microsomes|nmod|metabolism microsomes|nsubj|inhibitor inhibitor|compound|END_ENTITY	In vitro metabolism of rivaroxaban , an oral , direct factor_Xa inhibitor , in liver microsomes and hepatocytes of rats , dogs , and humans .
20062915	0	rivaroxaban	65,76	factor_Xa	95,104	rivaroxaban	factor Xa	MESH:C503223	2159	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY pharmacokinetics|dep|inhibitor inhibitor|compound|END_ENTITY	Safety , pharmacokinetics and pharmacodynamics of single doses of rivaroxaban - an oral , direct factor_Xa inhibitor - in elderly Chinese subjects .
20124518	0	rivaroxaban	118,129	factor_Xa	40,49	rivaroxaban	factor Xa	MESH:C503223	2159	Chemical	Gene	focus|nmod|START_ENTITY Role|dep|focus Role|nmod|antagonists antagonists|nmod|END_ENTITY	Role of orally available antagonists of factor_Xa in the treatment and prevention of thromboembolic_disease : focus on rivaroxaban .
20135059	0	rivaroxaban	43,54	factor_Xa	72,81	rivaroxaban	factor Xa	MESH:C503223	2159	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Assessment of laboratory assays to measure rivaroxaban -- an oral , direct factor_Xa inhibitor .
20617418	0	rivaroxaban	59,70	factor_Xa	12,21	rivaroxaban	factor Xa	MESH:C503223	2159	Chemical	Gene	inhibitors|nmod|START_ENTITY inhibitors|nsubj|END_ENTITY	Oral direct factor_Xa inhibitors , with special emphasis on rivaroxaban .
20806114	0	rivaroxaban	91,102	factor_Xa	69,78	rivaroxaban	factor Xa	MESH:C503223	2159	Chemical	Gene	inhibitors|appos|START_ENTITY inhibitors|compound|END_ENTITY	An optimised , rapid chromogenic assay , specific for measuring direct factor_Xa inhibitors -LRB- rivaroxaban -RRB- in plasma .
21666147	0	rivaroxaban	131,142	factor_Xa	53,62	rivaroxaban	factor Xa	MESH:C503223	2159	Chemical	Gene	focus|nmod|START_ENTITY thromboembolic_disease|dep|focus treatment|nmod|thromboembolic_disease Response|nmod|treatment Response|nmod|antagonists antagonists|nmod|END_ENTITY	Response to `` Role of orally available antagonists of factor_Xa in the treatment and prevention of thromboembolic_disease : focus on rivaroxaban '' .
23014816	0	rivaroxaban	45,56	factor_Xa	74,83	rivaroxaban	factor Xa	MESH:C503223	2159	Chemical	Gene	use|nmod|START_ENTITY guidance|nmod|use guidance|dep|inhibitor inhibitor|compound|END_ENTITY	Management consensus guidance for the use of rivaroxaban -- an oral , direct factor_Xa inhibitor .
23151091	0	rivaroxaban	189,200	factor_Xa	168,177	rivaroxaban	factor Xa	MESH:C503223	2159	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Preincubation in the Prothrombinase-induced Clotting Time test -LRB- PiCT -RRB- is necessary for in vitro evaluation of fondaparinux and to be avoided for the reversible , direct factor_Xa inhibitor , rivaroxaban .
23389892	0	rivaroxaban	64,75	factor_Xa	43,52	rivaroxaban	factor Xa	MESH:C503223	2159	Chemical	Gene	inhibitors|dobj|START_ENTITY inhibitors|nsubj|therapy therapy|nmod|END_ENTITY	Anticoagulant therapy with the oral direct factor_Xa inhibitors rivaroxaban , apixaban and edoxaban and the thrombin inhibitor dabigatran_etexilate in patients with hepatic_impairment .
24218999	0	rivaroxaban	41,52	factor_Xa	70,79	rivaroxaban	factor Xa	MESH:C503223	2159	Chemical	Gene	Pharmacokinetics|nmod|START_ENTITY Pharmacokinetics|dep|inhibitor inhibitor|compound|END_ENTITY	Pharmacokinetics and pharmacodynamics of rivaroxaban -- an oral , direct factor_Xa inhibitor .
24315894	0	rivaroxaban	82,93	factor_Xa	117,126	rivaroxaban	factor Xa	MESH:C503223	2159	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|compound|END_ENTITY	Factors associated with major_bleeding events : insights from the ROCKET AF trial -LRB- rivaroxaban once-daily oral direct factor_Xa inhibition compared with vitamin_K antagonism for prevention of stroke and embolism trial in atrial_fibrillation -RRB- .
24552831	0	rivaroxaban	140,151	factor_Xa	177,186	rivaroxaban	factor Xa	MESH:C503223	2159	Chemical	Gene	START_ENTITY|acl:relcl|inhibition inhibition|amod|END_ENTITY	Outcomes of temporary interruption of rivaroxaban compared with warfarin in patients with nonvalvular atrial_fibrillation : results from the rivaroxaban once daily , oral , direct factor_Xa inhibition compared with vitamin_K antagonism for prevention of stroke and embolism trial in atrial_fibrillation -LRB- ROCKET AF -RRB- .
24552831	0	rivaroxaban	38,49	factor_Xa	177,186	rivaroxaban	factor Xa	MESH:C503223	2159	Chemical	Gene	Outcomes|nmod|START_ENTITY Outcomes|nmod|patients patients|dep|results results|nmod|rivaroxaban rivaroxaban|acl:relcl|inhibition inhibition|amod|END_ENTITY	Outcomes of temporary interruption of rivaroxaban compared with warfarin in patients with nonvalvular atrial_fibrillation : results from the rivaroxaban once daily , oral , direct factor_Xa inhibition compared with vitamin_K antagonism for prevention of stroke and embolism trial in atrial_fibrillation -LRB- ROCKET AF -RRB- .
24743444	0	rivaroxaban	113,124	factor_Xa	150,159	rivaroxaban	factor Xa	MESH:C503223	2159	Chemical	Gene	once|nmod:npmod|START_ENTITY warfarin|advmod|once warfarin|dep|inhibition inhibition|compound|END_ENTITY	Intracranial_hemorrhage among patients with atrial_fibrillation anticoagulated with warfarin or rivaroxaban : the rivaroxaban once daily , oral , direct factor_Xa inhibition compared with vitamin_K antagonism for prevention of stroke and embolism trial in atrial_fibrillation .
26305919	0	rivaroxaban	73,84	factor_Xa	52,61	rivaroxaban	factor Xa	MESH:C503223	2159	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Comparison of the effects of heparin and the direct factor_Xa inhibitor , rivaroxaban , on bone microstructure and metabolism in adult rats .
26305919	0	rivaroxaban	73,84	factor_Xa	52,61	rivaroxaban	factor Xa	MESH:C503223	2159	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Comparison of the effects of heparin and the direct factor_Xa inhibitor , rivaroxaban , on bone microstructure and metabolism in adult rats .
26653339	0	rivaroxaban	119,130	factor_Xa	154,163	rivaroxaban	factor Xa	MESH:C503223	2159	Chemical	Gene	analysis|nmod|START_ENTITY patients|dep|analysis patients|dep|inhibition inhibition|compound|END_ENTITY	-LSB- Digoxin use in patients with atrial_fibrillation and adverse cardiovascular outcomes : A retrospective analysis of the rivaroxaban once daily oral direct factor_Xa inhibition compared with vitamin_K antagonism for prevention of stroke and embolism trial in atrial_fibrillation -LRB- ROCKET AF -RRB- -RSB- .
17595891	0	rivaroxaban	65,76	factor_xa	94,103	rivaroxaban	factor xa	MESH:C503223	2159	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY model|nmod|pharmacokinetics model|dep|oral oral|appos|inhibitor inhibitor|compound|END_ENTITY	Population model of the pharmacokinetics and pharmacodynamics of rivaroxaban -- an oral , direct factor_xa inhibitor -- in healthy subjects .
17873238	0	rivaroxaban	48,59	factor_xa	28,37	rivaroxaban	factor xa	MESH:C503223	2159	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|inhibitor inhibitor|compound|END_ENTITY	Effects of the oral , direct factor_xa inhibitor rivaroxaban on platelet-induced thrombin generation and prothrombinase activity .
18981864	0	rivaroxaban	41,52	factor_xa	20,29	rivaroxaban	factor xa	MESH:C503223	2159	Chemical	Gene	inhibitor|appos|START_ENTITY END_ENTITY|dep|inhibitor	Orally administered factor_xa inhibitor , rivaroxaban : a novel thromboembolic prophylaxis agent .
24768192	0	rivaroxaban	87,98	factor_xa	66,75	rivaroxaban	factor xa	MESH:C503223	2159	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Patient-reported compliance with thromboprophylaxis using an oral factor_xa inhibitor -LRB- rivaroxaban -RRB- following total hip and total knee arthroplasty .
24727881	0	rivastigmin	40,51	AChE	11,15	rivastigmin	AChE	null	43	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|Effect Effect|nmod|END_ENTITY	-LSB- Effect of AChE and BuChE inhibition by rivastigmin in a group of old-old elderly patients with cerebrovascular_impairment -LRB- SIVD type -RRB- -RSB- .
22323348	0	rivastigmin	29,40	aChE	0,4	rivastigmin	aChE	null	43	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	aChE and BuChE inhibition by rivastigmin have no effect on peripheral insulin resistance in elderly patients with Alzheimer_disease .
10673128	0	rivastigmine	8,20	acetylcholinesterase	34,54	rivastigmine	acetylcholinesterase	MESH:C072506	100009390(Tax:9986)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Topical rivastigmine , a selective acetylcholinesterase inhibitor , lowers intraocular pressure in rabbits .
23291013	0	rivastigmine	47,59	acetylcholinesterase	14,34	rivastigmine	acetylcholinesterase	MESH:C072506	101123006	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Inhibition of acetylcholinesterase activity by rivastigmine decreases lipopolysaccharide-induced IL-1b expression in the hypothalamus of ewes .
9737824	0	rivastigmine	25,37	acetylcholinesterase	56,76	rivastigmine	acetylcholinesterase	MESH:C072506	43	Chemical	Gene	pharmacology|nmod|START_ENTITY pharmacology|dep|inhibitor inhibitor|compound|END_ENTITY	Clinical pharmacology of rivastigmine : a new-generation acetylcholinesterase inhibitor for the treatment of Alzheimer 's _ disease .
12566177	0	rivastigmine	128,140	apolipoprotein_E	89,105	rivastigmine	apolipoprotein E	MESH:C072506	348	Chemical	Gene	genotype|nmod|START_ENTITY genotype|amod|END_ENTITY	Cerebral glucose metabolism , cerebrospinal fluid-beta-amyloid1-42 -LRB- CSF-Abeta42 -RRB- , tau and apolipoprotein_E genotype in long-term rivastigmine and tacrine treated Alzheimer_disease -LRB- AD -RRB- patients .
19809220	0	rivoglitazone	31,44	peroxisome_proliferator-activated_receptor-gamma	54,102	rivoglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C521549	25664(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Potent antidiabetic effects of rivoglitazone , a novel peroxisome_proliferator-activated_receptor-gamma agonist , in obese diabetic rodent models .
15944648	0	rizatriptan	38,49	5-HT1B	11,17	rizatriptan	5-HT1B	MESH:C093622	3351	Chemical	Gene	Effects|dep|START_ENTITY Effects|nmod|END_ENTITY	Effects of 5-HT1B / 1D receptor agonist rizatriptan on cerebral blood flow and blood volume in normal circulation .
15174248	0	rizatriptan	62,73	calcitonin_gene-related_peptide	77,108	rizatriptan	calcitonin gene-related peptide	MESH:C093622	796	Chemical	Gene	START_ENTITY|nmod|concentration concentration|amod|END_ENTITY	-LSB- Suppressing effect of the serotonin 5HT1B/D receptor agonist rizatriptan on calcitonin_gene-related_peptide -LRB- CGRP -RRB- concentration in migraine attacks -RSB- .
19788468	0	rizatriptan	109,120	calcitonin_gene-related_peptide	16,47	rizatriptan	calcitonin gene-related peptide	MESH:C093622	796	Chemical	Gene	predict|nmod|START_ENTITY predict|nsubj|levels levels|amod|END_ENTITY	Elevated saliva calcitonin_gene-related_peptide levels during acute migraine predict therapeutic response to rizatriptan .
25524408	0	rizatriptan	11,22	calcitonin_gene-related_peptide	44,75	rizatriptan	calcitonin gene-related peptide	MESH:C093622	24241(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of rizatriptan on the expression of calcitonin_gene-related_peptide and cholecystokinin in the periaqueductal gray of a rat migraine model .
24586947	0	roadside	6,14	Alien	0,5	roadside	Alien	null	9318	Chemical	Gene	species|compound|START_ENTITY species|compound|END_ENTITY	Alien roadside species more easily invade alpine than lowland plant communities in a subarctic mountain ecosystem .
19161452	0	robenacoxib	120,131	COX-2	99,104	robenacoxib	COX-2	MESH:C551524	807936(Tax:9685)	Chemical	Gene	START_ENTITY|amod|selective selective|amod|END_ENTITY	Use of a pharmacokinetic/pharmacodynamic approach in the cat to determine a dosage regimen for the COX-2 selective drug robenacoxib .
19161451	0	robenacoxib	28,39	cyclooxygenase-2	72,88	robenacoxib	cyclooxygenase-2	MESH:C551524	29527(Tax:10116)	Chemical	Gene	pharmacology|nmod|START_ENTITY pharmacology|dep|inhibitor inhibitor|nmod|END_ENTITY	Preclinical pharmacology of robenacoxib : a novel selective inhibitor of cyclooxygenase-2 .
26747242	0	rociletinib	112,123	EGFR	14,18	rociletinib	EGFR	MESH:C000589977	1956	Chemical	Gene	study|nmod|START_ENTITY patients|nmod|study plasma|nmod|patients status|nmod|plasma status|amod|END_ENTITY	Assessment of EGFR mutation status in matched plasma and tumor tissue of NSCLC patients from a phase 1 study of rociletinib -LRB- CO-1686 -RRB- .
10555907	0	rofecoxib	124,133	COX-2	19,24	rofecoxib	COX-2	MESH:C116926	5743	Chemical	Gene	study|nmod|START_ENTITY Effect|dep|study Effect|nmod|inhibition inhibition|compound|END_ENTITY	Effect of specific COX-2 inhibition in osteoarthritis_of_the_knee : a 6 week double blind , placebo controlled pilot study of rofecoxib .
10986213	0	rofecoxib	136,145	COX-2	0,5	rofecoxib	COX-2	MESH:C116926	5743	Chemical	Gene	comparing|dobj|START_ENTITY study|acl|comparing permeability|dep|study increase|dobj|permeability increase|nsubj|inhibition inhibition|compound|END_ENTITY	COX-2 inhibition with rofecoxib does not increase intestinal permeability in healthy subjects : a double blind crossover study comparing rofecoxib with placebo and indomethacin .
10986213	0	rofecoxib	22,31	COX-2	0,5	rofecoxib	COX-2	MESH:C116926	5743	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	COX-2 inhibition with rofecoxib does not increase intestinal permeability in healthy subjects : a double blind crossover study comparing rofecoxib with placebo and indomethacin .
11041909	0	rofecoxib	82,91	COX-2	65,70	rofecoxib	COX-2	MESH:C116926	5743	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|tolerability tolerability|nmod|cyclooxygenase-2 cyclooxygenase-2|appos|END_ENTITY	Gastrointestinal tolerability of the selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitor rofecoxib compared with nonselective COX-1 and COX-2 inhibitors in osteoarthritis .
11199547	0	rofecoxib	26,35	COX-2	8,13	rofecoxib	COX-2	MESH:C116926	4513	Chemical	Gene	inhibitors|dep|START_ENTITY inhibitors|compound|END_ENTITY	The new COX-2 inhibitors : rofecoxib -LRB- Vioxx -RRB- and celecoxib -LRB- Celebrex -RRB- .
11425807	0	rofecoxib	86,95	COX-2	70,75	rofecoxib	COX-2	MESH:C116926	4513	Chemical	Gene	START_ENTITY|amod|human human|nmod|END_ENTITY	Induction of delayed follicular rupture in the human by the selective COX-2 inhibitor rofecoxib : a randomized double-blind study .
11703585	4	rofecoxib	754,763	COX-2	824,829	rofecoxib	COX-2	MESH:C116926	26198(Tax:10116)	Chemical	Gene	received|dobj|START_ENTITY received|nmod|inhibition inhibition|nmod|END_ENTITY	In addition , parallel groups received rofecoxib -LRB- 1 to 10 mg/kg body weight/day -RRB- for selective inhibition of COX-2 .
11706832	0	rofecoxib	14,23	COX-2	27,32	rofecoxib	COX-2	MESH:C116926	4513	Chemical	Gene	Discussion|nmod|START_ENTITY Discussion|appos|inhibitor inhibitor|compound|END_ENTITY	Discussion on rofecoxib , a COX-2 inhibitor , does not inhibit human gastric mucosal prostaglandin production .
12406411	0	rofecoxib	53,62	COX-2	40,45	rofecoxib	COX-2	MESH:C116926	4513	Chemical	Gene	NSAID|advmod|START_ENTITY NSAID|nsubj|evaluation evaluation|nmod|END_ENTITY	-LSB- Economic evaluation of a new selective COX-2 NSAID , rofecoxib , in a real practice context -RSB- .
14627349	0	rofecoxib	33,42	COX-2	13,18	rofecoxib	COX-2	MESH:C116926	5743	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|Influence Influence|nmod|END_ENTITY	Influence of COX-2 inhibition by rofecoxib on serum and tumor progastrin and gastrin levels and expression of PPARgamma and apoptosis-related proteins in gastric_cancer patients .
15082814	0	rofecoxib	123,132	COX-2	107,112	rofecoxib	COX-2	MESH:C116926	4513	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|case case|nmod|END_ENTITY	Applying a research ethics committee approach to a medical practice controversy : the case of the selective COX-2 inhibitor rofecoxib .
15179440	0	rofecoxib	96,105	COX-2	69,74	rofecoxib	COX-2	MESH:C116926	4513	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|selective selective|amod|END_ENTITY	Prevention of heterotopic_ossification after spinal_cord_injury with COX-2 selective inhibitor -LRB- rofecoxib -RRB- .
15355480	0	rofecoxib	42,51	COX-2	26,31	rofecoxib	COX-2	MESH:C116926	4513	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|safety safety|nmod|END_ENTITY	Partial safety of the new COX-2 inhibitor rofecoxib in NSAIDs high sensitive patients .
15623076	0	rofecoxib	15,24	COX-2	70,75	rofecoxib	COX-2	MESH:C116926	4513	Chemical	Gene	START_ENTITY|dep|selective selective|nmod|safety safety|nmod|END_ENTITY	-LSB- Withdrawal of rofecoxib -LRB- Vioxx -RRB- : what about cardiovascular safety of COX-2 selective non-steroidal anti-inflammatory drugs ? -RSB- .
15720519	0	rofecoxib	68,77	COX-2	81,86	rofecoxib	COX-2	MESH:C116926	804479(Tax:9615)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|selective selective|amod|END_ENTITY	Superiority of the gastroduodenal safety profile of licofelone over rofecoxib , a COX-2 selective inhibitor , in dogs .
15883736	0	rofecoxib	21,30	COX-2	4,9	rofecoxib	COX-2	MESH:C116926	17709(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	The COX-2 inhibitor , rofecoxib , ameliorates dextran sulphate_sodium induced colitis in mice .
15902994	0	rofecoxib	51,60	COX-2	10,15	rofecoxib	COX-2	MESH:C116926	4513	Chemical	Gene	doses|nmod|START_ENTITY inhibition|nmod|doses inhibition|compound|END_ENTITY	Selective COX-2 inhibition with different doses of rofecoxib does not impair endothelial function in patients with coronary_artery_disease .
16934053	0	rofecoxib	32,41	COX-2	69,74	rofecoxib	COX-2	MESH:C116926	4513	Chemical	Gene	START_ENTITY|nmod|patterns patterns|nmod|END_ENTITY	The effect of the withdrawal of rofecoxib on prescribing patterns of COX-2 inhibitors in Scotland .
17222987	0	rofecoxib	133,142	COX-2	29,34	rofecoxib	COX-2	MESH:C116926	4513	Chemical	Gene	trials|amod|START_ENTITY structuring|nmod|trials useful|advcl|structuring proposed|xcomp|useful proposed|nsubj|mechanism mechanism|nmod|cardiovascular_events cardiovascular_events|compound|END_ENTITY	A pathogenetic mechanism for COX-2 inhibitor-induced cardiovascular_events proposed to be useful in structuring medical testimony in rofecoxib trials .
17612051	0	rofecoxib	54,63	COX-2	97,102	rofecoxib	COX-2	MESH:C116926	4513	Chemical	Gene	effects|nmod|START_ENTITY rationale|nmod|effects rationale|dep|analysis analysis|nmod|agents agents|compound|END_ENTITY	A biological rationale for the cardiotoxic effects of rofecoxib : comparative analysis with other COX-2 selective agents and NSAids .
17636557	0	rofecoxib	119,128	COX-2	42,47	rofecoxib	COX-2	MESH:C116926	5743	Chemical	Gene	withdrawn|nsubjpass|START_ENTITY happened|advcl|withdrawn happened|nmod|prescribing prescribing|nmod|inhibitors inhibitors|compound|END_ENTITY	What happened to the prescribing of other COX-2 inhibitors , paracetamol and non-steroidal anti-inflammatory drugs when rofecoxib was withdrawn in Australia ?
17706175	0	rofecoxib	28,37	COX-2	77,82	rofecoxib	COX-2	MESH:C116926	5743	Chemical	Gene	analogs|compound|START_ENTITY analogs|nmod|inhibitors inhibitors|appos|END_ENTITY	Design and synthesis of new rofecoxib analogs as selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors : replacement of the methanesulfonyl pharmacophore by a N-acetylsulfonamido bioisostere .
17963198	0	rofecoxib	77,86	COX-2	50,55	rofecoxib	COX-2	MESH:C116926	4513	Chemical	Gene	withdrawal|amod|START_ENTITY inhibitors|nmod|withdrawal inhibitors|nsubj|stopping stopping|nmod|END_ENTITY	Large-scale stopping and switching treatment with COX-2 inhibitors after the rofecoxib withdrawal .
18344196	0	rofecoxib	119,128	COX-2	66,71	rofecoxib	COX-2	MESH:C116926	26198(Tax:10116)	Chemical	Gene	drugs|amod|START_ENTITY drugs|amod|selective selective|amod|END_ENTITY	Effect of inflammation on kidney function and pharmacokinetics of COX-2 selective nonsteroidal anti-inflammatory drugs rofecoxib and meloxicam .
14504873	0	rofecoxib	37,46	COX_2	50,55	rofecoxib	COX 2	MESH:C116926	4513	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	A comparative study of the effect of rofecoxib -LRB- a COX_2 inhibitor -RRB- and naproxen_sodium on analgesic requirements after abdominal hysterectomy .
14524083	0	rofecoxib	27,36	COX_2	11,16	rofecoxib	COX 2	MESH:C116926	4513	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|END_ENTITY	-LSB- Selective COX_2 inhibitor rofecoxib .
14517190	0	rofecoxib	60,69	CYP1A2	94,100	rofecoxib	CYP1A2	MESH:C116926	1544	Chemical	Gene	CYP1A2|nmod|START_ENTITY inhibition|nmod|CYP1A2 evaluation|nmod|inhibition evaluation|acl|using using|nmod|probe probe|compound|END_ENTITY	An evaluation of the dose-dependent inhibition of CYP1A2 by rofecoxib using theophylline as a CYP1A2 probe .
11413920	0	rofecoxib	35,44	Cox-2	15,20	rofecoxib	Cox-2	MESH:C116926	4513	Chemical	Gene	-LSB-|nmod|START_ENTITY -LSB-|dobj|inhibition inhibition|compound|END_ENTITY	-LSB- The selective Cox-2 inhibition by rofecoxib reduces risk of severe gastrointestinal_complications of anti-inflammatory therapy by more than 50 % -RSB- .
15136060	4	rofecoxib	744,753	Cox-2	766,771	rofecoxib	Cox-2	MESH:C116926	5743	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	HDL-induced PGI -LRB- 2 -RRB- release was inhibited by rofecoxib -LRB- a specific Cox-2 inhibitor , 5 microM -RRB- .
10391671	0	rofecoxib	31,40	Cyclooxygenase-2	0,16	rofecoxib	Cyclooxygenase-2	MESH:C116926	5743	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Cyclooxygenase-2 inhibition by rofecoxib reverses naturally occurring fever in humans .
11739299	0	rofecoxib	123,132	Cyclooxygenase-2	0,16	rofecoxib	Cyclooxygenase-2	MESH:C116926	5743	Chemical	Gene	evaluation|nmod|START_ENTITY function|dep|evaluation impair|dobj|function impair|nsubj|blockade blockade|amod|END_ENTITY	Cyclooxygenase-2 blockade does not impair endothelial vasodilator function in healthy volunteers : randomized evaluation of rofecoxib versus naproxen on endothelium-dependent vasodilatation .
12389882	0	rofecoxib	76,85	Cyclooxygenase-2	0,16	rofecoxib	Cyclooxygenase-2	MESH:C116926	5743	Chemical	Gene	report|nmod|START_ENTITY acute_renal_failure|dep|report acute_renal_failure|amod|END_ENTITY	Cyclooxygenase-2 inhibitor-associated acute_renal_failure : case report with rofecoxib and review of the literature .
22108833	0	rofecoxib	106,115	Cyclooxygenase-2	0,16	rofecoxib	Cyclooxygenase-2	MESH:C116926	5743	Chemical	Gene	withdrawal|nmod|START_ENTITY study|nmod|withdrawal study|nsubj|inhibitors inhibitors|amod|END_ENTITY	Cyclooxygenase-2 inhibitors and cardiovascular risk in a nation-wide cohort study after the withdrawal of rofecoxib .
12695355	0	rofecoxib	40,49	UGT2B7	21,27	rofecoxib	UGT2B7	MESH:C116926	7364	Chemical	Gene	metabolism|amod|START_ENTITY Involvement|nmod|metabolism Involvement|nmod|END_ENTITY	Involvement of human UGT2B7 and 2B15 in rofecoxib metabolism .
12786631	0	rofecoxib	66,75	cyclo-oxygenase-2	37,54	rofecoxib	cyclo-oxygenase-2	MESH:C116926	5743	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	An open-label trial of the selective cyclo-oxygenase-2 inhibitor , rofecoxib , in inflammatory_bowel_disease-associated peripheral arthritis and arthralgia .
14642796	0	rofecoxib	33,42	cyclo-oxygenase-2	4,21	rofecoxib	cyclo-oxygenase-2	MESH:C116926	29527(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	The cyclo-oxygenase-2 inhibitor , rofecoxib , attenuates mucosal_damage due to colitis induced by trinitrobenzene_sulphonic_acid in rats .
16671960	0	rofecoxib	10,19	cyclo-oxygenase-2	23,40	rofecoxib	cyclo-oxygenase-2	MESH:C116926	19225(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effect of rofecoxib , a cyclo-oxygenase-2 inhibitor , on various biochemical parameters of brain associated with pentylenetetrazol-induced chemical kindling in mice .
10096266	0	rofecoxib	20,29	cyclooxygenase-2	35,51	rofecoxib	cyclooxygenase-2	MESH:C116926	5743	Chemical	Gene	START_ENTITY|nmod|isoform isoform|amod|END_ENTITY	Characterization of rofecoxib as a cyclooxygenase-2 isoform inhibitor and demonstration of analgesia in the dental pain model .
10566562	0	rofecoxib	14,23	cyclooxygenase-2	43,59	rofecoxib	cyclooxygenase-2	MESH:C116926	5743	Chemical	Gene	START_ENTITY|appos|inhibitors inhibitors|amod|END_ENTITY	Comparison of rofecoxib and celecoxib , two cyclooxygenase-2 inhibitors , in postoperative dental pain : a randomized , placebo - and active-comparator-controlled clinical trial .
10997947	0	rofecoxib	58,67	cyclooxygenase-2	92,108	rofecoxib	cyclooxygenase-2	MESH:C116926	29527(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	The absorption , distribution , metabolism and excretion of rofecoxib , a potent and selective cyclooxygenase-2 inhibitor , in rats and dogs .
11041909	0	rofecoxib	82,91	cyclooxygenase-2	47,63	rofecoxib	cyclooxygenase-2	MESH:C116926	5743	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|tolerability tolerability|nmod|END_ENTITY	Gastrointestinal tolerability of the selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitor rofecoxib compared with nonselective COX-1 and COX-2 inhibitors in osteoarthritis .
11092584	0	rofecoxib	17,26	cyclooxygenase-2	40,56	rofecoxib	cyclooxygenase-2	MESH:C116926	5743	Chemical	Gene	Determination|nmod|START_ENTITY Determination|appos|inhibitor inhibitor|amod|END_ENTITY	Determination of rofecoxib -LRB- MK-0966 -RRB- , a cyclooxygenase-2 inhibitor , in human plasma by high-performance_liquid_chromatography with tandem mass spectrometric detection .
11136272	0	rofecoxib	55,64	cyclooxygenase-2	98,114	rofecoxib	cyclooxygenase-2	MESH:C116926	5743	Chemical	Gene	profile|nmod|START_ENTITY article|dep|profile article|appos|inhibitor inhibitor|nmod|END_ENTITY	Review article : the gastrointestinal safety profile of rofecoxib , a highly selective inhibitor of cyclooxygenase-2 , in humans .
11185674	0	rofecoxib	34,43	cyclooxygenase-2	6,22	rofecoxib	cyclooxygenase-2	MESH:C116926	5743	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	A new cyclooxygenase-2 inhibitor , rofecoxib -LRB- VIOXX -RRB- , did not alter the antiplatelet effects of low-dose aspirin in healthy volunteers .
11245490	0	rofecoxib	68,77	cyclooxygenase-2	90,106	rofecoxib	cyclooxygenase-2	MESH:C116926	19225(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Chemoprevention of intestinal_polyposis in the Apcdelta716 mouse by rofecoxib , a specific cyclooxygenase-2 inhibitor .
12019196	0	rofecoxib	34,43	cyclooxygenase-2	68,84	rofecoxib	cyclooxygenase-2	MESH:C116926	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	The disposition and metabolism of rofecoxib , a potent and selective cyclooxygenase-2 inhibitor , in human subjects .
12217369	0	rofecoxib	30,39	cyclooxygenase-2	86,102	rofecoxib	cyclooxygenase-2	MESH:C116926	5743	Chemical	Gene	analogues|nmod|START_ENTITY analogues|dep|class class|nmod|inhibitors inhibitors|amod|END_ENTITY	Isomeric acetoxy analogues of rofecoxib : a novel class of highly potent and selective cyclooxygenase-2 inhibitors .
12745131	0	rofecoxib	132,141	cyclooxygenase-2	78,94	rofecoxib	cyclooxygenase-2	MESH:C116926	5743	Chemical	Gene	celecoxib|nmod|START_ENTITY celecoxib|amod|END_ENTITY	Blood pressure control and rates of edema following the administration of the cyclooxygenase-2 specific inhibitors celecoxib versus rofecoxib in patients with systemic hypertension and osteoarthritis .
14581346	0	rofecoxib	71,80	cyclooxygenase-2	94,110	rofecoxib	cyclooxygenase-2	MESH:C116926	5743	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	A randomized , double-blind , placebo-controlled trial of the effects of rofecoxib , a selective cyclooxygenase-2 inhibitor , on rectal_polyps in familial_adenomatous_polyposis patients .
14642682	0	rofecoxib	43,52	cyclooxygenase-2	10,26	rofecoxib	cyclooxygenase-2	MESH:C116926	5743	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|inhibition inhibition|amod|END_ENTITY	Effect of cyclooxygenase-2 inhibition with rofecoxib on endothelial_dysfunction and inflammatory markers in patients with coronary_artery_disease .
15050636	0	rofecoxib	64,73	cyclooxygenase-2	177,193	rofecoxib	cyclooxygenase-2	MESH:C116926	5743	Chemical	Gene	analogues|nmod|START_ENTITY Sulfonamido|appos|analogues inhibitor|nsubj|Sulfonamido inhibitor|amod|END_ENTITY	Sulfonamido , azidosulfonyl and N-acetylsulfonamido analogues of rofecoxib : 4 - -LSB- 4 - -LRB- N-acetylsulfonamido -RRB- phenyl -RSB- -3 - -LRB- 4-methanesulfonylphenyl -RRB- -2 -LRB- 5H -RRB- furanone is a potent and selective cyclooxygenase-2 inhibitor .
16584081	0	rofecoxib	41,50	cyclooxygenase-2	13,29	rofecoxib	cyclooxygenase-2	MESH:C116926	29527(Tax:10116)	Chemical	Gene	Effects|appos|START_ENTITY Effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Effects of a cyclooxygenase-2 inhibitor -LRB- rofecoxib -RRB- on bone healing .
17076866	0	rofecoxib	10,19	cyclooxygenase-2	34,50	rofecoxib	cyclooxygenase-2	MESH:C116926	5743	Chemical	Gene	withdrawal|amod|START_ENTITY Impact|nmod|withdrawal Impact|nmod|utilization utilization|amod|END_ENTITY	Impact of rofecoxib withdrawal on cyclooxygenase-2 utilization among patients with and without cardiovascular risk .
17706175	0	rofecoxib	28,37	cyclooxygenase-2	59,75	rofecoxib	cyclooxygenase-2	MESH:C116926	5743	Chemical	Gene	analogs|compound|START_ENTITY analogs|nmod|inhibitors inhibitors|amod|END_ENTITY	Design and synthesis of new rofecoxib analogs as selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors : replacement of the methanesulfonyl pharmacophore by a N-acetylsulfonamido bioisostere .
20110006	0	rofecoxib	101,110	cyclooxygenase-2	47,63	rofecoxib	cyclooxygenase-2	MESH:C116926	5743	Chemical	Gene	withdrawal|nmod|START_ENTITY prescribing|nmod|withdrawal prescribing|dobj|inhibitor inhibitor|amod|END_ENTITY	Changes in physicians ' practice of prescribing cyclooxygenase-2 inhibitor after market withdrawal of rofecoxib : a retrospective study of physician-patient pairs in Taiwan .
24672083	0	rofecoxib	11,20	cyclooxygenase-2	34,50	rofecoxib	cyclooxygenase-2	MESH:C116926	29527(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effects of rofecoxib , a selective cyclooxygenase-2 inhibitor , on endothelial_dysfunction , lipid peroxidation , and hepatocyte morphology in rats with sepsis-induced liver_damage .
10693877	0	rofecoxib	28,37	cyclooxygenase_2	41,57	rofecoxib	cyclooxygenase 2	MESH:C116926	5743	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|inhibitor inhibitor|amod|END_ENTITY	Comparison of the effect of rofecoxib -LRB- a cyclooxygenase_2 inhibitor -RRB- , ibuprofen , and placebo on the gastroduodenal mucosa of patients with osteoarthritis : a randomized , double-blind , placebo-controlled trial .
15702813	0	rofecoxib	119,128	cyclooxygenase_2	91,107	rofecoxib	cyclooxygenase 2	MESH:C116926	5743	Chemical	Gene	inhibitors|xcomp|START_ENTITY inhibitors|nsubj|Tolerance Tolerance|nmod|patients patients|nmod|END_ENTITY	Tolerance of nonsteroidal anti-inflammatory drug-sensitive patients to the highly specific cyclooxygenase_2 inhibitors rofecoxib and valdecoxib .
18668614	0	rofecoxib	121,130	cyclooxygenase_2	64,80	rofecoxib	cyclooxygenase 2	MESH:C116926	5743	Chemical	Gene	withdrawal|nmod|START_ENTITY prescribed|nmod|withdrawal prescribed|dobj|inhibitors inhibitors|amod|END_ENTITY	Changes in the characteristics of patients prescribed selective cyclooxygenase_2 inhibitors after the 2004 withdrawal of rofecoxib .
24106801	0	roflumilast	66,77	Cystic_fibrosis_transmembrane_conductance_regulator	0,51	roflumilast	Cystic fibrosis transmembrane conductance regulator	MESH:C424423	1080	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Cystic_fibrosis_transmembrane_conductance_regulator activation by roflumilast contributes to therapeutic benefit in chronic bronchitis .
11259554	0	roflumilast	77,88	PDE4	62,66	roflumilast	PDE4	MESH:C424423	5141	Chemical	Gene	START_ENTITY|nsubj|potential potential|nmod|inhibitor inhibitor|compound|END_ENTITY	Anti-inflammatory and immunomodulatory potential of the novel PDE4 inhibitor roflumilast in vitro .
16257550	0	roflumilast	71,82	PDE4	93,97	roflumilast	PDE4	MESH:C424423	5141	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Inhibition of airway hyperresponsiveness and pulmonary_inflammation by roflumilast and other PDE4 inhibitors .
23389862	0	roflumilast	201,212	Phosphodiesterase_4	0,19	roflumilast	Phosphodiesterase 4	MESH:C424423	5141	Chemical	Gene	efficacy|nmod|START_ENTITY mechanism|nmod|efficacy cells|dep|mechanism ability|nmod|cells augment|dobj|ability inhibitors|xcomp|augment inhibitors|nsubj|END_ENTITY	Phosphodiesterase_4 inhibitors augment the ability of formoterol to enhance glucocorticoid-dependent gene transcription in human airway epithelial cells : a novel mechanism for the clinical efficacy of roflumilast in severe chronic_obstructive_pulmonary_disease .
16389572	0	roflumilast	26,37	heme_oxygenase-1	126,142	roflumilast	heme oxygenase-1	MESH:C424423	15368(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY mediated|nsubjpass|effects mediated|nmod|END_ENTITY	The inhibitory effects of roflumilast on lipopolysaccharide-induced nitric_oxide production in RAW264 .7 cells are mediated by heme_oxygenase-1 and its product carbon_monoxide .
20381629	0	roflumilast	32,43	phosphodiesterase_4	63,82	roflumilast	phosphodiesterase 4	MESH:C424423	5141	Chemical	Gene	pharmacology|nmod|START_ENTITY pharmacology|dep|inhibitor inhibitor|amod|END_ENTITY	The preclinical pharmacology of roflumilast -- a selective , oral phosphodiesterase_4 inhibitor in development for chronic_obstructive_pulmonary_disease .
21232047	0	roflumilast	10,21	phosphodiesterase_4	25,44	roflumilast	phosphodiesterase 4	MESH:C424423	5141	Chemical	Gene	Update|nmod|START_ENTITY Update|appos|inhibitor inhibitor|amod|END_ENTITY	Update on roflumilast , a phosphodiesterase_4 inhibitor for the treatment of chronic_obstructive_pulmonary_disease .
24027357	0	roflumilast_N-oxide	37,56	NOX4	18,22	roflumilast N-oxide	NOX4	MESH:C517734	50507	Chemical	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Downregulation of NOX4 expression by roflumilast_N-oxide reduces markers of fibrosis in lung fibroblasts .
1659868	0	rogletimide	39,50	aromatase	18,27	rogletimide	aromatase	MESH:C049837	100721069	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	The effect of the aromatase inhibitor , rogletimide -LRB- pyridoglutethimide -RRB- , on guinea_pig adrenal cell steroidogenesis and placental microsomal aromatase activity : comparison with aminoglutethimide and CGS_16949A .
8273597	0	rolipram	11,19	IL-2	34,38	rolipram	IL-2	MESH:D020889	3558	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|transcription transcription|compound|END_ENTITY	Effects of rolipram and CI-930 on IL-2 mRNA transcription in human Jurkat cells .
10749688	0	rolipram	10,18	PDE4	31,35	rolipram	PDE4	MESH:D020889	5141	Chemical	Gene	START_ENTITY|nmod|isoforms isoforms|compound|END_ENTITY	Action of rolipram on specific PDE4 cAMP phosphodiesterase isoforms and on the phosphorylation of cAMP-response-element-binding_protein -LRB- CREB -RRB- and p38 mitogen-activated protein -LRB- MAP -RRB- kinase in U937 monocytic cells .
9245486	0	rolipram	25,33	TNF-alpha	37,46	rolipram	TNF-alpha	MESH:D020889	21926(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	The inhibitory effect of rolipram on TNF-alpha production in mouse blood ex vivo is dependent upon the release of corticosterone and adrenaline .
9550429	0	rolipram	115,123	TNF-alpha	15,24	rolipram	TNF-alpha	MESH:D020889	21926(Tax:10090)	Chemical	Gene	collagen-induced_arthritis|nmod|START_ENTITY Suppression|nmod|collagen-induced_arthritis Suppression|nmod|expression expression|amod|END_ENTITY	Suppression of TNF-alpha expression , inhibition of Th1 activity , and amelioration of collagen-induced_arthritis by rolipram .
15233866	0	rolipram	46,54	Th1	58,61	rolipram	Th1	MESH:D020889	57314(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of the phosphodiesterase IV inhibitor rolipram on Th1 and Th2 immune responses in mice .
8786537	0	rolipram	69,77	renin	15,20	rolipram	renin	MESH:D020889	100358545(Tax:9986)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Stimulation Stimulation|nmod|END_ENTITY	Stimulation of renin secretion by the phosphodiesterase IV inhibitor rolipram .
11367521	0	romurtide	128,137	tumor_necrosis_factor-alpha	13,40	romurtide	tumor necrosis factor-alpha	MESH:C036866	21926(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Induction Induction|nmod|END_ENTITY	Induction of tumor_necrosis_factor-alpha in solid tumor region by the orally administered synthetic muramyl_dipeptide analogue , romurtide .
23225637	0	rooperol	80,88	p38a	100,104	rooperol	p38a	MESH:C079659	1432	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|amod|END_ENTITY	A fluorescence-based assay for p38a recruitment site binders : identification of rooperol as a novel p38a kinase inhibitor .
18165569	0	ropivacaine	47,58	CYP2D6	62,68	ropivacaine	CYP2D6	MESH:C037663	1565	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	The effect of a long term epidural infusion of ropivacaine on CYP2D6 activity .
23218601	0	roscovitine	39,50	CDK5	21,25	roscovitine	CDK5	MESH:C104586	1020	Chemical	Gene	derived|nmod|START_ENTITY END_ENTITY|acl|derived	Potent inhibitors of CDK5 derived from roscovitine : synthesis , biological evaluation and molecular modelling .
15659113	0	roscovitine	30,41	Cdk5	51,55	roscovitine	Cdk5	MESH:C104586	140908(Tax:10116)	Chemical	Gene	administration|nmod|START_ENTITY inhibits|nsubj|administration inhibits|dobj|activity activity|amod|END_ENTITY	Intrathecal administration of roscovitine inhibits Cdk5 activity and attenuates formalin-induced nociceptive response in rats .
18588979	0	roscovitine	45,56	Cdk5	60,64	roscovitine	Cdk5	MESH:C104586	140908(Tax:10116)	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY pharmacokinetics|nmod|END_ENTITY	Age-dependent pharmacokinetics and effect of roscovitine on Cdk5 and Erk1/2 in the rat brain .
9030780	0	roscovitine	107,118	cdk2	87,91	roscovitine	cdk2	MESH:C104586	1017	Chemical	Gene	complexed|nmod|START_ENTITY END_ENTITY|acl|complexed	Inhibition of cyclin-dependent kinases by purine analogues : crystal structure of human cdk2 complexed with roscovitine .
15301735	0	roscovitine	28,39	cdk5	12,16	roscovitine	cdk5	MESH:C104586	140908(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Intrathecal cdk5 inhibitor , roscovitine , attenuates morphine antinociceptive tolerance in rats .
18457570	0	roscovitine	10,21	cyclin_B-dependent_kinase_1	35,62	roscovitine	cyclin B-dependent kinase 1	MESH:C104586	983	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effect of roscovitine , a selective cyclin_B-dependent_kinase_1 inhibitor , on assembly of the nucleolus in mitosis .
15985434	0	roscovitine	54,65	pyridoxal_kinase	21,37	roscovitine	pyridoxal kinase	MESH:C104586	8566	Chemical	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Crystal structure of pyridoxal_kinase in complex with roscovitine and derivatives .
15562399	0	rosglitazone	11,23	adiponectin	34,45	rosglitazone	adiponectin	null	9370	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of rosglitazone on plasma adiponectin , insulin sensitivity , and insulin secretion in high-risk African Americans with impaired_glucose_tolerance test and type 2 diabetes .
19321784	0	rosiglitazone	99,112	5-lipoxygenase	27,41	rosiglitazone	5-lipoxygenase	MESH:C089730	25290(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|amod|END_ENTITY	Synthesis of lipoxin A4 by 5-lipoxygenase mediates PPARgamma-dependent , neuroprotective effects of rosiglitazone in experimental stroke .
11994296	0	rosiglitazone	24,37	AMP-activated_protein_kinase	62,90	rosiglitazone	AMP-activated protein kinase	MESH:C089730	5563	Chemical	Gene	stimulate|nsubj|START_ENTITY stimulate|dobj|END_ENTITY	The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated_protein_kinase through distinct signaling pathways .
17084402	0	rosiglitazone	73,86	Adiponectin	0,11	rosiglitazone	Adiponectin	MESH:C089730	9370	Chemical	Gene	treatment|amod|START_ENTITY associated|nmod|treatment associated|nsubjpass|END_ENTITY	Adiponectin is associated with improvement of endothelial function after rosiglitazone treatment in non-diabetic individuals with metabolic_syndrome .
12689821	0	rosiglitazone	90,103	C-reactive_protein	56,74	rosiglitazone	C-reactive protein	MESH:C089730	1401	Chemical	Gene	reversal|nmod|START_ENTITY effects|dep|reversal effects|nmod|END_ENTITY	Hyperglycemia potentiates the proatherogenic effects of C-reactive_protein : reversal with rosiglitazone .
12695287	0	rosiglitazone	10,23	CD40L	45,50	rosiglitazone	CD40L	MESH:C089730	959	Chemical	Gene	treatment|amod|START_ENTITY Effect|nmod|treatment Effect|nmod|END_ENTITY	Effect of rosiglitazone treatment on soluble CD40L in patients with type_2_diabetes_and_coronary_artery_disease .
19056168	1	rosiglitazone	459,472	COX-2	226,231	rosiglitazone	COX-2	MESH:C089730	5743	Chemical	Gene	inhibitor|appos|START_ENTITY combination|nmod|inhibitor effects|nmod|combination remains|nsubj|effects remains|advcl|leads leads|nsubj|inhibition inhibition|nmod|cyclooxygenase-2 cyclooxygenase-2|appos|END_ENTITY	Although inhibition of cyclooxygenase-2 -LRB- COX-2 -RRB- or activation of peroxisome_proliferators-activated_receptor_gamma -LRB- PPAR-gamma -RRB- leads to growth inhibition in malignancies , the synergistic anti-tumor effects of combination of COX-2 inhibitor -LRB- NS-398 -RRB- and PPAR-gamma agonist -LRB- rosiglitazone -RRB- on the human pancreatic_cancer cells remains unknown .
15606443	0	rosiglitazone	46,59	CYP2C8	30,36	rosiglitazone	CYP2C8	MESH:C089730	1558	Chemical	Gene	metabolism|amod|START_ENTITY mediated|dobj|metabolism mediated|nsubj|effect effect|nmod|trimethoprim trimethoprim|nmod|END_ENTITY	The effect of trimethoprim on CYP2C8 mediated rosiglitazone metabolism in human liver microsomes and healthy subjects .
16027405	0	rosiglitazone	47,60	CYP2C8	64,70	rosiglitazone	CYP2C8	MESH:C089730	1558	Chemical	Gene	START_ENTITY|appos|substrate substrate|compound|END_ENTITY	Effect of quercetin on the pharmacokinetics of rosiglitazone , a CYP2C8 substrate , in healthy subjects .
16856883	0	rosiglitazone	80,93	CYP2C8	21,27	rosiglitazone	CYP2C8	MESH:C089730	1558	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY genotype|nmod|pharmacokinetics genotype|nsubj|effects effects|nmod|END_ENTITY	The effects of human CYP2C8 genotype and fluvoxamine on the pharmacokinetics of rosiglitazone in healthy subjects .
16981900	0	rosiglitazone	67,80	CYP2C8	84,90	rosiglitazone	CYP2C8	MESH:C089730	1558	Chemical	Gene	START_ENTITY|appos|substrate substrate|compound|END_ENTITY	Effect of multiple doses of montelukast on the pharmacokinetics of rosiglitazone , a CYP2C8 substrate , in humans .
17178266	0	rosiglitazone	41,54	CYP2C8	70,76	rosiglitazone	CYP2C8	MESH:C089730	1558	Chemical	Gene	START_ENTITY|nmod|relation relation|nmod|END_ENTITY	Pharmacokinetics and pharmacodynamics of rosiglitazone in relation to CYP2C8 genotype .
21245287	0	rosiglitazone	111,124	CYP2C8	40,46	rosiglitazone	CYP2C8	MESH:C089730	1558	Chemical	Gene	disposition|amod|START_ENTITY *|nmod|disposition *|nsubj|Discovery Discovery|nmod|variant variant|nmod|CYP2C8 CYP2C8|compound|END_ENTITY	Discovery of a novel allelic variant of CYP2C8 , CYP2C8 * 11 , in Asian populations and its clinical effect on the rosiglitazone disposition in vivo .
21245287	0	rosiglitazone	111,124	CYP2C8	48,54	rosiglitazone	CYP2C8	MESH:C089730	1558	Chemical	Gene	disposition|amod|START_ENTITY *|nmod|disposition *|nsubj|Discovery Discovery|nmod|variant variant|nmod|END_ENTITY	Discovery of a novel allelic variant of CYP2C8 , CYP2C8 * 11 , in Asian populations and its clinical effect on the rosiglitazone disposition in vivo .
23307233	0	rosiglitazone	169,182	CYP2C8	146,152	rosiglitazone	CYP2C8	MESH:C089730	1558	Chemical	Gene	exposure|amod|START_ENTITY polymorphism|nmod|exposure polymorphism|amod|modelling modelling|xcomp|investigate investigate|dobj|impact impact|nmod|END_ENTITY	Application of in vitro-in vivo extrapolation -LRB- IVIVE -RRB- and physiologically based pharmacokinetic -LRB- PBPK -RRB- modelling to investigate the impact of the CYP2C8 polymorphism on rosiglitazone exposure .
23426382	0	rosiglitazone	118,131	CYP2C8	32,38	rosiglitazone	CYP2C8	MESH:C089730	1558	Chemical	Gene	concentrations|nmod|START_ENTITY role|nmod|concentrations role|nmod|END_ENTITY	The role of genetic variants in CYP2C8 , LPIN1 , PPARGC1A and PPARy on the trough steady-state plasma concentrations of rosiglitazone and on glycosylated haemoglobin A1c in type 2 diabetes .
25854986	0	rosiglitazone	202,215	CYP2C8	179,185	rosiglitazone	CYP2C8	MESH:C089730	1558	Chemical	Gene	PK|compound|START_ENTITY PK|compound|END_ENTITY	Pharmacokinetic -LRB- PK -RRB- drug interaction studies of cabozantinib : Effect of CYP3A inducer rifampin and inhibitor ketoconazole on cabozantinib plasma PK and effect of cabozantinib on CYP2C8 probe substrate rosiglitazone plasma PK .
25052610	0	rosiglitazone	11,24	HIF1a	46,51	rosiglitazone	HIF1a	MESH:C089730	3091	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of rosiglitazone on the expression of HIF1a and IGF1 mRNA in myeloma -RSB- .
20671417	0	rosiglitazone	10,23	IGF-I	33,38	rosiglitazone	IGF-I	MESH:C089730	3479	Chemical	Gene	START_ENTITY|nmod|concentrations concentrations|amod|END_ENTITY	Effect of rosiglitazone on serum IGF-I concentrations in uncontrolled acromegalic patients under conventional medical therapy : results from a pilot phase 2 study .
17950491	0	rosiglitazone	54,67	Interleukin-4	0,13	rosiglitazone	Interleukin-4	MESH:C089730	287287(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY mediates|dobj|effects mediates|nsubj|END_ENTITY	Interleukin-4 mediates the neuroprotective effects of rosiglitazone in the aged brain .
17903364	0	rosiglitazone	12,25	KLF6	52,56	rosiglitazone	KLF6	MESH:C089730	58954(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|factor factor|appos|END_ENTITY	-LSB- Effects of rosiglitazone on Kruppul-like factor 6 -LRB- KLF6 -RRB- signaling in the livers of rats with nonalcoholic_fatty_liver_fibrosis -RSB- .
22040807	0	rosiglitazone	14,27	LRP1	31,35	rosiglitazone	LRP1	MESH:C089730	4035	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	The effect of rosiglitazone on LRP1 expression and amyloid b uptake in human brain microvascular endothelial cells : a possible role of a low-dose thiazolidinedione for dementia treatment .
22889684	6	rosiglitazone	751,764	LRP1	686,690	rosiglitazone	LRP1	MESH:C089730	299858(Tax:10116)	Chemical	Gene	increased|nmod|START_ENTITY increased|nsubjpass|mRNA mRNA|compound|END_ENTITY	LRP1 mRNA and protein expressions were increased by 0.5 and 5 M rosiglitazone in HepG2 cells .
12588772	0	rosiglitazone	34,47	MMP-9	56,61	rosiglitazone	MMP-9	MESH:C089730	4318	Chemical	Gene	reduces|advmod|START_ENTITY reduces|dobj|levels levels|compound|END_ENTITY	Antidiabetic PPAR_gamma-activator rosiglitazone reduces MMP-9 serum levels in type 2 diabetic patients with coronary_artery_disease .
19201691	0	rosiglitazone	17,30	MMP-9	136,141	rosiglitazone	MMP-9	MESH:C089730	81687(Tax:10116)	Chemical	Gene	mechanism|nmod|START_ENTITY reduce|nsubj|mechanism reduce|parataxis|followed followed|nmod|inhibition inhibition|nmod|END_ENTITY	New mechanism of rosiglitazone to reduce neointimal_hyperplasia : activation of glycogen_synthase_kinase-3beta followed by inhibition of MMP-9 .
19674806	0	rosiglitazone	10,23	MMP-9	96,101	rosiglitazone	MMP-9	MESH:C089730	4318	Chemical	Gene	Effect|nmod|START_ENTITY serum|nsubj|Effect serum|dobj|levels levels|amod|END_ENTITY	Effect of rosiglitazone , metformin and medical nutrition treatment on arterial stiffness , serum MMP-9 and MCP-1 levels in drug naive type 2 diabetic patients .
20021931	0	rosiglitazone	31,44	MMP-9	48,53	rosiglitazone	MMP-9	MESH:C089730	4318	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effects of PPAR-gamma agonist rosiglitazone on MMP-9 and TIMP-1 expression of monocyte-derived macrophages isolated from patients with acute_coronary_syndrome -RSB- .
24548695	0	rosiglitazone	11,24	PPAR	26,30	rosiglitazone	PPAR	MESH:C089730	25747(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|agonist agonist|amod|END_ENTITY	Effects of rosiglitazone -LRB- PPAR y agonist -RRB- on the myocardium in non-hypertensive diabetic rats .
11774944	0	rosiglitazone	45,58	PPAR-gamma	27,37	rosiglitazone	PPAR-gamma	MESH:C089730	5468	Chemical	Gene	START_ENTITY|nsubj|trial trial|nmod|ligand ligand|amod|END_ENTITY	An open-label trial of the PPAR-gamma ligand rosiglitazone for active ulcerative_colitis .
12663234	0	rosiglitazone	90,103	PPAR-gamma	72,82	rosiglitazone	PPAR-gamma	MESH:C089730	5468	Chemical	Gene	hepatic_steatosis|amod|START_ENTITY ligand|dobj|hepatic_steatosis ligand|nsubj|results results|nmod|study study|acl|demonstrating demonstrating|dobj|effects effects|nmod|END_ENTITY	Interim results of a pilot study demonstrating the early effects of the PPAR-gamma ligand rosiglitazone on insulin sensitivity , aminotransferases , hepatic_steatosis and body weight in patients with non-alcoholic_steatohepatitis .
15296471	0	rosiglitazone	55,68	PPAR-gamma	37,47	rosiglitazone	PPAR-gamma	MESH:C089730	5468	Chemical	Gene	ligand|dobj|START_ENTITY ligand|nsubj|Effects Effects|nmod|administration administration|nmod|END_ENTITY	Effects of chronic administration of PPAR-gamma ligand rosiglitazone in Cushing 's _ disease .
17094055	0	rosiglitazone	34,47	PPAR-gamma	15,25	rosiglitazone	PPAR-gamma	MESH:C089730	5468	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|agonist agonist|amod|END_ENTITY	Effects of the PPAR-gamma agonist rosiglitazone on renal haemodynamics and the renin-angiotensin system in diabetes .
17463185	0	rosiglitazone	86,99	PPAR-gamma	0,10	rosiglitazone	PPAR-gamma	MESH:C089730	19016(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY abolishes|dobj|effect abolishes|nsubj|knockout knockout|amod|END_ENTITY	PPAR-gamma knockout in pancreatic epithelial cells abolishes the inhibitory effect of rosiglitazone on caerulein-induced acute pancreatitis .
19357642	0	rosiglitazone	49,62	PPAR-gamma	30,40	rosiglitazone	PPAR-gamma	MESH:C089730	5468	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|agonist agonist|amod|END_ENTITY	Bronchodilatory effect of the PPAR-gamma agonist rosiglitazone in smokers with asthma .
19919817	0	rosiglitazone	36,49	PPAR-gamma	17,27	rosiglitazone	PPAR-gamma	MESH:C089730	5468	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|agonist agonist|amod|END_ENTITY	No effect of the PPAR-gamma agonist rosiglitazone on ACTH or cortisol secretion in Nelson 's _ syndrome and Cushing 's _ disease in vitro and in vivo .
20401461	0	rosiglitazone	25,38	PPAR-gamma	104,114	rosiglitazone	PPAR-gamma	MESH:C089730	19016(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|peroxisome_proliferator-activated_receptor-gamma peroxisome_proliferator-activated_receptor-gamma|appos|END_ENTITY	Sex dimorphic actions of rosiglitazone in generalised peroxisome_proliferator-activated_receptor-gamma -LRB- PPAR-gamma -RRB- - deficient mice .
20441053	0	rosiglitazone	37,50	PPAR-gamma	18,28	rosiglitazone	PPAR-gamma	MESH:C089730	5468	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|agonist agonist|amod|END_ENTITY	The effect of the PPAR-gamma agonist rosiglitazone on neuroblastoma SK-N-SH cells in a metastatic xenograft mouse model .
20444009	0	rosiglitazone	11,24	PPAR-gamma	28,38	rosiglitazone	PPAR-gamma	MESH:C089730	281993(Tax:9913)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Effects of rosiglitazone , a PPAR-gamma agonist , on the contractility of bovine uterus in vitro .
20729387	0	rosiglitazone	44,57	PPAR-gamma	25,35	rosiglitazone	PPAR-gamma	MESH:C089730	25664(Tax:10116)	Chemical	Gene	prevents|advmod|START_ENTITY prevents|nsubj|agonist agonist|amod|END_ENTITY	Antenatally administered PPAR-gamma agonist rosiglitazone prevents hyperoxia-induced neonatal rat_lung_injury .
23388479	0	rosiglitazone	83,96	PPAR-gamma	63,73	rosiglitazone	PPAR-gamma	MESH:C089730	25664(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Comparison Comparison|nmod|actions actions|nmod|agonists agonists|amod|END_ENTITY	Comparison of the anti-inflammatory and therapeutic actions of PPAR-gamma agonists rosiglitazone and troglitazone in experimental colitis .
25789586	0	rosiglitazone	150,163	PPAR-gamma	130,140	rosiglitazone	PPAR-gamma	MESH:C089730	5468	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Damage to vascular endothelial cells by high insulin levels is associated with increased expression of ChemR23 , and attenuated by PPAR-gamma agonist , rosiglitazone .
23791613	0	rosiglitazone	21,34	PPAR-y	0,6	rosiglitazone	PPAR-y	MESH:C089730	5468	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	PPAR-y activation by rosiglitazone suppresses angiotensin_II-mediated proliferation and phenotypictransition in cardiac fibroblasts via inhibition of activation of activator_protein_1 .
12504108	5	rosiglitazone	771,784	PPAR_gamma	966,976	rosiglitazone	PPAR gamma	MESH:C089730	5468	Chemical	Gene	START_ENTITY|advmod|upstream upstream|nmod|sequence sequence|acl|identified identified|dobj|elements elements|acl:relcl|shown shown|nmod|END_ENTITY	Resistin expression was reduced by up to 80 % after exposure to 100 nM rosiglitazone for 96 h. Bioinformatics analysis of the genomic sequence upstream of the resistin coding sequence identified several putative PPAR response elements of which one was shown to bind PPAR_gamma using electrophoretic mobility shift assays .
17461532	0	rosiglitazone	55,68	PPAR_gamma	13,23	rosiglitazone	PPAR gamma	MESH:C089730	25664(Tax:10116)	Chemical	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	Induction of PPAR_gamma mRNA and protein expression by rosiglitazone in chronic cyclosporine nephropathy in the rat .
18810647	0	rosiglitazone	20,33	PPAR_gamma	0,10	rosiglitazone	PPAR gamma	MESH:C089730	5468	Chemical	Gene	ligands|amod|START_ENTITY ligands|compound|END_ENTITY	PPAR_gamma ligands , rosiglitazone and pioglitazone , inhibit bFGF - and VEGF-mediated angiogenesis .
9934490	0	rosiglitazone	25,38	PPAR_gamma	54,64	rosiglitazone	PPAR gamma	MESH:C089730	5468	Chemical	Gene	activity|nmod|START_ENTITY enantiomers|nsubj|activity enantiomers|nmod|END_ENTITY	Differential activity of rosiglitazone enantiomers at PPAR_gamma .
11399762	3	rosiglitazone	621,634	PPARgamma	484,493	rosiglitazone	PPARgamma	MESH:C089730	373928(Tax:9031)	Chemical	Gene	START_ENTITY|nmod|elements elements|amod|END_ENTITY	Of the two PPARgamma response elements , gAF1/PCK1 and PCK2 , only PCK2 is required for PEPCK expression and responsiveness to the PPARgamma agonist , rosiglitazone , in adipose tissue even though both elements bind PPARgamma/RXR in vitro .
12401879	0	rosiglitazone	55,68	PPARgamma	37,46	rosiglitazone	PPARgamma	MESH:C089730	19016(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|agonist agonist|compound|END_ENTITY	Lipid metabolome-wide effects of the PPARgamma agonist rosiglitazone .
15533890	0	rosiglitazone	142,155	PPARgamma	174,183	rosiglitazone	PPARgamma	MESH:C089730	5468	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activation activation|compound|END_ENTITY	GW9662 , a potent antagonist of PPARgamma , inhibits growth of breast_tumour cells and promotes the anticancer effects of the PPARgamma agonist rosiglitazone , independently of PPARgamma activation .
15549648	0	rosiglitazone	120,133	PPARgamma	92,101	rosiglitazone	PPARgamma	MESH:C089730	25664(Tax:10116)	Chemical	Gene	BRL49653|appos|START_ENTITY BRL49653|compound|END_ENTITY	Enhanced marrow adipogenesis and bone resorption in estrogen-deprived rats treated with the PPARgamma agonist BRL49653 -LRB- rosiglitazone -RRB- .
16110522	0	rosiglitazone	35,48	PPARgamma	18,27	rosiglitazone	PPARgamma	MESH:C089730	5468	Chemical	Gene	ligand|dobj|START_ENTITY ligand|nsubj|effect effect|nmod|END_ENTITY	The effect of the PPARgamma ligand rosiglitazone on energy balance regulation .
16286236	0	rosiglitazone	22,35	PPARgamma	4,13	rosiglitazone	PPARgamma	MESH:C089730	19016(Tax:10090)	Chemical	Gene	ligand|appos|START_ENTITY ligand|compound|END_ENTITY	The PPARgamma ligand , rosiglitazone , reduces airways hyperresponsiveness in a murine model of allergen-induced inflammation .
16430724	0	rosiglitazone	36,49	PPARgamma	53,62	rosiglitazone	PPARgamma	MESH:C089730	5468	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Effect of protracted treatment with rosiglitazone , a PPARgamma agonist , in patients with Cushing 's _ disease .
16499094	0	rosiglitazone	29,42	PPARgamma	11,20	rosiglitazone	PPARgamma	MESH:C089730	100008892(Tax:9986)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|agonist agonist|compound|END_ENTITY	-LSB- Effect of PPARgamma agonist rosiglitazone on regression of the atherosclerotic_plaques in rabbits -RSB- .
16672634	0	rosiglitazone	27,40	PPARgamma	119,128	rosiglitazone	PPARgamma	MESH:C089730	19016(Tax:10090)	Chemical	Gene	activation|amod|START_ENTITY effect|nmod|activation effect|dep|mechanism mechanism|nmod|effects effects|nmod:poss|agonist agonist|compound|END_ENTITY	Adipose-specific effect of rosiglitazone on vascular permeability and protein_kinase_C activation : novel mechanism for PPARgamma agonist 's effects on edema and weight_gain .
17122083	0	rosiglitazone	78,91	PPARgamma	64,73	rosiglitazone	PPARgamma	MESH:C089730	5468	Chemical	Gene	components|amod|START_ENTITY Activation|nmod|components Activation|appos|END_ENTITY	Activation of peroxisome_proliferator-activated_receptor_gamma -LRB- PPARgamma -RRB- by rosiglitazone suppresses components of the insulin-like growth factor regulatory system in vitro and in vivo .
17337254	0	rosiglitazone	22,35	PPARgamma	4,13	rosiglitazone	PPARgamma	MESH:C089730	19016(Tax:10090)	Chemical	Gene	ligand|appos|START_ENTITY ligand|compound|END_ENTITY	The PPARgamma ligand , rosiglitazone , reduces vascular oxidative stress and NADPH oxidase expression in diabetic mice .
17390024	10	rosiglitazone	1668,1681	PPARgamma	1578,1587	rosiglitazone	PPARgamma	MESH:C089730	5468	Chemical	Gene	effect|nmod|START_ENTITY blocked|dobj|effect GW9662|acl:relcl|blocked GW9662|compound|END_ENTITY	To confirm the involvement of PPARgamma in thiazolidinedione-induced CXCR4 down-regulation , we used PPARgamma antagonists GW9662 and T0070907 , both of which completely blocked the effect of rosiglitazone on CXCR4 expression .
17909895	0	rosiglitazone	72,85	PPARgamma	54,63	rosiglitazone	PPARgamma	MESH:C089730	19016(Tax:10090)	Chemical	Gene	levels|amod|START_ENTITY ligand|dobj|levels ligand|nsubj|peroxisome_proliferator_activated_receptor_gamma peroxisome_proliferator_activated_receptor_gamma|appos|END_ENTITY	The peroxisome_proliferator_activated_receptor_gamma -LRB- PPARgamma -RRB- ligand rosiglitazone modulates bronchoalveolar lavage levels of leptin , adiponectin , and inflammatory cytokines in lean and obese mice .
18177513	0	rosiglitazone	21,34	PPARgamma	144,153	rosiglitazone	PPARgamma	MESH:C089730	5468	Chemical	Gene	influences|nsubj|START_ENTITY influences|advcl|increasing increasing|dobj|activity activity|nmod|END_ENTITY	The PPARgamma ligand rosiglitazone influences triacylglycerol metabolism in non-obese males , without increasing the transcriptional activity of PPARgamma in the subcutaneous adipose tissue .
18269641	0	rosiglitazone	75,88	PPARgamma	56,65	rosiglitazone	PPARgamma	MESH:C089730	25664(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	Energy restriction enhances therapeutic efficacy of the PPARgamma agonist , rosiglitazone , through regulation of visceral fat gene expression .
18506083	0	rosiglitazone	114,127	PPARgamma	20,29	rosiglitazone	PPARgamma	MESH:C089730	19016(Tax:10090)	Chemical	Gene	treatment|amod|START_ENTITY Impact|nmod|treatment Impact|nmod|activity activity|compound|END_ENTITY	Impact of increased PPARgamma activity in adipocytes in vivo on adiposity , insulin sensitivity and the effects of rosiglitazone treatment .
19201733	0	rosiglitazone	48,61	PPARgamma	30,39	rosiglitazone	PPARgamma	MESH:C089730	25664(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|agonist agonist|compound|END_ENTITY	Depot-specific effects of the PPARgamma agonist rosiglitazone on adipose tissue glucose uptake and metabolism .
19261916	0	rosiglitazone	121,134	PPARgamma	0,9	rosiglitazone	PPARgamma	MESH:C089730	25664(Tax:10116)	Chemical	Gene	focus|nmod|START_ENTITY adipose|dep|focus handling|nmod|adipose regulates|dobj|handling regulates|nsubj|END_ENTITY	PPARgamma differentially regulates energy substrate handling in brown vs. white adipose : focus on `` The PPARgamma agonist rosiglitazone enhances rat brown adipose tissue lipogenesis from glucose without altering glucose uptake '' .
19300395	0	rosiglitazone	11,24	PPARgamma	77,86	rosiglitazone	PPARgamma	MESH:C089730	5468	Chemical	Gene	Effects|nmod|START_ENTITY Effects|dep|gamma gamma|appos|END_ENTITY	Effects of rosiglitazone -- peroxisome proliferators-activated receptor gamma -LRB- PPARgamma -RRB- agonist on cell viability of human pituitary_adenomas in vitro .
19443733	0	rosiglitazone	27,40	PPARgamma	14,23	rosiglitazone	PPARgamma	MESH:C089730	5468	Chemical	Gene	attenuates|amod|START_ENTITY END_ENTITY|nmod|attenuates	Activation of PPARgamma by rosiglitazone attenuates intestinal Cl - secretion .
19451898	0	rosiglitazone	19,32	PPARgamma	0,9	rosiglitazone	PPARgamma	MESH:C089730	25664(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	PPARgamma agonist , rosiglitazone , regulates angiotensin_II-induced vascular_inflammation through the TLR4-dependent signaling pathway .
20193324	0	rosiglitazone	44,57	PPARgamma	27,36	rosiglitazone	PPARgamma	MESH:C089730	5468	Chemical	Gene	ligand|xcomp|START_ENTITY ligand|nsubj|effect effect|nmod|END_ENTITY	-LSB- Differentiating effect of PPARgamma ligand rosiglitazone and all_trans-retinoic_acid on myeloma cells and its possible mechanism -RSB- .
20527969	0	rosiglitazone	244,257	PPARgamma	175,184	rosiglitazone	PPARgamma	MESH:C089730	19016(Tax:10090)	Chemical	Gene	efficacy|nmod|START_ENTITY agonists|nmod|efficacy Design|dep|agonists Design|dep|acids acids|nmod|peroxisome_proliferator-activated_receptor_gamma peroxisome_proliferator-activated_receptor_gamma|appos|END_ENTITY	Design , synthesis , and structure-activity relationship studies of novel 2,4,6-trisubstituted-5-pyrimidinecarboxylic _ acids as peroxisome_proliferator-activated_receptor_gamma -LRB- PPARgamma -RRB- partial agonists with comparable antidiabetic efficacy to rosiglitazone .
19902320	0	rosiglitazone	127,140	Peroxisome_proliferator-activated_receptor-gamma	0,48	rosiglitazone	Peroxisome proliferator-activated receptor-gamma	MESH:C089730	25664(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY cardiac_fibrosis|dobj|effect cardiac_fibrosis|nsubj|attenuates attenuates|amod|END_ENTITY	Peroxisome_proliferator-activated_receptor-gamma activation attenuates cardiac_fibrosis in type_2_diabetic rats : the effect of rosiglitazone on myocardial expression of receptor_for_advanced_glycation_end_products and of connective_tissue_growth_factor .
9703335	0	rosiglitazone	58,71	Peroxisome_proliferator-activated_receptor-gamma	0,48	rosiglitazone	Peroxisome proliferator-activated receptor-gamma	MESH:C089730	25664(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Peroxisome_proliferator-activated_receptor-gamma agonist , rosiglitazone , protects against nephropathy and pancreatic_islet_abnormalities in Zucker fatty rats .
18455351	0	rosiglitazone	58,71	Peroxisome_proliferator-activated_receptor_gamma	0,48	rosiglitazone	Peroxisome proliferator-activated receptor gamma	MESH:C089730	25664(Tax:10116)	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Peroxisome_proliferator-activated_receptor_gamma agonist , rosiglitazone , suppresses CD40 expression and attenuates inflammatory responses after lithium_pilocarpine-induced status_epilepticus in rats .
15665514	0	rosiglitazone	23,36	SERCA2	49,55	rosiglitazone	SERCA2	MESH:C089730	29693(Tax:10116)	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	The antidiabetic agent rosiglitazone upregulates SERCA2 and enhances TNF-alpha - and LPS-induced NF-kappaB-dependent transcription and TNF-alpha-induced IL-6 secretion in ventricular myocytes .
19563079	0	rosiglitazone	15,28	STAT1	48,53	rosiglitazone	STAT1	MESH:C089730	25124(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	-LSB- The effect of rosiglitazone on the activity of STAT1 in rats with severe acute pancreatitis -RSB- .
20606418	0	rosiglitazone	18,31	STAT1	84,89	rosiglitazone	STAT1	MESH:C089730	20846(Tax:10090)	Chemical	Gene	Renoprotection|nmod|START_ENTITY Renoprotection|dep|Role Role|nmod|inhibition inhibition|amod|END_ENTITY	Renoprotection by rosiglitazone in accelerated type 2 diabetic_nephropathy : Role of STAT1 inhibition and nephrin restoration .
20196958	0	rosiglitazone	11,24	Skp2	69,73	rosiglitazone	Skp2	MESH:C089730	6502	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of rosiglitazone on cells cycle , apoptosis and expression of Skp2 and p27Kip1 in hepatocellular_carcinoma cell line -RSB- .
18846339	0	rosiglitazone	16,29	TLR4	41,45	rosiglitazone	TLR4	MESH:C089730	21898(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Significance of rosiglitazone inhibiting TLR4 expression in partial hepatic_ischemia / reperfusion of mice .
18438653	0	rosiglitazone	59,72	TNF-alpha	46,55	rosiglitazone	TNF-alpha	MESH:C089730	7124	Chemical	Gene	response|amod|START_ENTITY END_ENTITY|nmod|response	Impact of genetic polymorphisms of leptin and TNF-alpha on rosiglitazone response in Chinese patients with type 2 diabetes .
26178497	0	rosiglitazone	12,25	TNFa	39,43	rosiglitazone	TNFa	MESH:C089730	24835(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|nmod|END_ENTITY	-LSB- Effects of rosiglitazone on levels of TNFa in septic rats with acute kidney_injury -RSB- .
21406603	0	rosiglitazone	33,46	TRPM3	79,84	rosiglitazone	TRPM3	MESH:C089730	80036	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Rapid and contrasting effects of rosiglitazone on transient receptor potential TRPM3 and TRPC5 channels .
12630940	0	rosiglitazone	11,24	UCP-3	43,48	rosiglitazone	UCP-3	MESH:C089730	7352	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of rosiglitazone and oleic_acid on UCP-3 expression in L6 myotubes .
21694775	0	rosiglitazone	25,38	Visfatin	0,8	rosiglitazone	Visfatin	MESH:C089730	10135	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Visfatin is regulated by rosiglitazone in type_2_diabetes_mellitus and influenced by NFkB and JNK in human abdominal subcutaneous adipocytes .
18948967	0	rosiglitazone	63,76	acyl-CoA_dehydrogenases	18,41	rosiglitazone	acyl-CoA dehydrogenases	MESH:C089730	11409(Tax:10090)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	The regulation of acyl-CoA_dehydrogenases in adipose tissue by rosiglitazone .
17721754	0	rosiglitazone	11,24	brain_natriuretic_peptide	35,60	rosiglitazone	brain natriuretic peptide	MESH:C089730	4879	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|compound|END_ENTITY	Effects of rosiglitazone on plasma brain_natriuretic_peptide levels and myocardial performance index in patients with type_2_diabetes_mellitus .
20684283	0	rosiglitazone	12,25	connective_tissue_growth_factor	47,78	rosiglitazone	connective tissue growth factor	MESH:C089730	64032(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of rosiglitazone on the expression of connective_tissue_growth_factor in the pulmonary arteries of rats suffering from fibrosis in lung -RSB- .
19528204	0	rosiglitazone	11,24	fibroblast_growth_factor-21	43,70	rosiglitazone	fibroblast growth factor-21	MESH:C089730	26291	Chemical	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Effects of rosiglitazone on fasting plasma fibroblast_growth_factor-21 levels in patients with type_2_diabetes_mellitus .
24459515	0	rosiglitazone	11,24	heat_shock_protein	28,46	rosiglitazone	heat shock protein	MESH:C089730	290549(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of rosiglitazone on heat_shock_protein and the endothelin system in deoxycorticosterone_acetate-salt hypertensive rats .
23707273	0	rosiglitazone	57,70	heme_oxygenase-1	125,141	rosiglitazone	heme oxygenase-1	MESH:C089730	3162	Chemical	Gene	attenuates|nsubj|START_ENTITY attenuates|nmod|induction induction|nmod|END_ENTITY	Peroxisome_proliferator-activated_receptor-gamma agonist rosiglitazone attenuates inflammatory_pain through the induction of heme_oxygenase-1 in macrophages .
11704136	0	rosiglitazone	134,147	insulin	15,22	rosiglitazone	insulin	MESH:C089730	3630	Chemical	Gene	treated|nmod|START_ENTITY polycystic_ovary_syndrome|acl:relcl|treated followed|nmod|polycystic_ovary_syndrome followed|nsubj|Improvement Improvement|nmod|sensitivity sensitivity|compound|END_ENTITY	Improvement in insulin sensitivity followed by ovulation and pregnancy in a woman with polycystic_ovary_syndrome who was treated with rosiglitazone .
12593999	0	rosiglitazone	95,108	insulin	14,21	rosiglitazone	insulin	MESH:C089730	3630	Chemical	Gene	Correction|nmod|START_ENTITY Correction|nmod|resistance resistance|compound|END_ENTITY	Correction of insulin resistance and hyperandrogenism_in_polycystic_ovary_syndrome by combined rosiglitazone and clomiphene_citrate therapy .
12663234	0	rosiglitazone	90,103	insulin	107,114	rosiglitazone	insulin	MESH:C089730	3630	Chemical	Gene	START_ENTITY|nmod|sensitivity sensitivity|compound|END_ENTITY	Interim results of a pilot study demonstrating the early effects of the PPAR-gamma ligand rosiglitazone on insulin sensitivity , aminotransferases , hepatic_steatosis and body weight in patients with non-alcoholic_steatohepatitis .
12915671	0	rosiglitazone	13,26	insulin	149,156	rosiglitazone	insulin	MESH:C089730	3630	Chemical	Gene	treatment|amod|START_ENTITY Influence|nmod|treatment Influence|dep|evidence evidence|nmod|ability ability|acl|entrain entrain|dobj|END_ENTITY	Influence of rosiglitazone treatment on beta-cell function in type 2 diabetes : evidence of an increased ability of glucose to entrain high-frequency insulin pulsatility .
14747233	0	rosiglitazone	20,33	insulin	46,53	rosiglitazone	insulin	MESH:C089730	3630	Chemical	Gene	therapy|amod|START_ENTITY therapy|nmod|resistance resistance|compound|END_ENTITY	In type 2 diabetes , rosiglitazone therapy for insulin resistance ameliorates endothelial_dysfunction independent of glucose control .
15486228	0	rosiglitazone	132,145	insulin	71,78	rosiglitazone	insulin	MESH:C089730	101823595	Chemical	Gene	ameliorated|nmod|START_ENTITY ameliorated|nsubjpass|overproduction overproduction|appos|component component|nmod|resistance resistance|compound|END_ENTITY	Intestinal lipoprotein overproduction , a newly recognized component of insulin resistance , is ameliorated by the insulin sensitizer rosiglitazone : studies in the fructose-fed Syrian_golden_hamster .
15994753	0	rosiglitazone	10,23	insulin	27,34	rosiglitazone	insulin	MESH:C089730	3630	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	Effect of rosiglitazone on insulin resistance , C-reactive_protein and endothelial function in non-obese young women with polycystic_ovary_syndrome .
16719233	0	rosiglitazone	10,23	insulin	46,53	rosiglitazone	insulin	MESH:C089730	3630	Chemical	Gene	START_ENTITY|nmod|levels levels|dep|END_ENTITY	Impact of rosiglitazone on glycaemic control , insulin levels and blood pressure values in patients with type 2 diabetes .
17403121	0	rosiglitazone	86,99	insulin	134,141	rosiglitazone	insulin	MESH:C089730	3630	Chemical	Gene	START_ENTITY|advcl|starting starting|dobj|therapy therapy|compound|END_ENTITY	A double-blind randomized study comparing the effects of continuing or not continuing rosiglitazone + metformin therapy when starting insulin therapy in people with Type 2 diabetes .
18074413	0	rosiglitazone	10,23	insulin	41,48	rosiglitazone	insulin	MESH:C089730	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|resistance resistance|compound|END_ENTITY	Effect of rosiglitazone and metformin on insulin resistance in patients infected with human immunodeficiency virus receiving highly active antiretroviral therapy containing protease inhibitor : randomized prospective controlled clinical trial .
19217454	0	rosiglitazone	197,210	insulin	32,39	rosiglitazone	insulin	MESH:C089730	3630	Chemical	Gene	pioglitazone|nmod|START_ENTITY Relationship|dep|pioglitazone Relationship|nmod|changes changes|nmod|sensitivity sensitivity|compound|END_ENTITY	Relationship between changes in insulin sensitivity and associated cardiovascular_disease risk factors in thiazolidinedione-treated , insulin-resistant , nondiabetic individuals : pioglitazone versus rosiglitazone .
19888409	0	rosiglitazone	25,38	insulin	70,77	rosiglitazone	insulin	MESH:C089730	3630	Chemical	Gene	treatment|nmod|START_ENTITY Impact|nmod|treatment Impact|nmod|biomarkers biomarkers|nmod|resistance resistance|compound|END_ENTITY	Impact of treatment with rosiglitazone or metformin on biomarkers for insulin resistance and metabolic_syndrome in patients with polycystic_ovary_syndrome .
20158105	3	rosiglitazone	388,401	insulin	578,585	rosiglitazone	insulin	MESH:C089730	3630	Chemical	Gene	gamma|amod|START_ENTITY treatment|nmod|gamma offer|nsubj|treatment offer|advcl|lowering lowering|dobj|END_ENTITY	Pharmacologic treatment with thiazolidinedions , such as rosiglitazone and pioglitazone , agonists of the nuclear receptor peroxisome proliferator-activated receptor gamma -LRB- PPARgamma -RRB- , may offer some therapeutic relief of AD by lowering peripheral insulin and enhancing insulin sensitivity .
23983807	0	rosiglitazone	23,36	insulin	77,84	rosiglitazone	insulin	MESH:C089730	3630	Chemical	Gene	START_ENTITY|nmod|means means|acl|treating treating|dobj|resistance resistance|compound|END_ENTITY	Electroacupuncture and rosiglitazone combined therapy as a means of treating insulin resistance and type_2_diabetes_mellitus : a randomized controlled trial .
24683246	0	rosiglitazone	34,47	insulin	51,58	rosiglitazone	insulin	MESH:C089730	3630	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	Effectiveness and tolerability of rosiglitazone on insulin resistance and body composition in nondiabetic Thai patients undergoing continuous ambulatory peritoneal dialysis : A 12-week pilot study .
25621136	0	rosiglitazone	43,56	insulin	60,67	rosiglitazone	insulin	MESH:C089730	3630	Chemical	Gene	START_ENTITY|nmod|therapy therapy|compound|END_ENTITY	Effect and cardiovascular safety of adding rosiglitazone to insulin therapy in type 2 diabetes : A meta-analysis .
26317056	0	rosiglitazone	38,51	insulin	16,23	rosiglitazone	insulin	MESH:C089730	3630	Chemical	Gene	resistance|nmod|START_ENTITY resistance|compound|END_ENTITY	Amelioration of insulin resistance by rosiglitazone is associated with increased adipose cell size in obese type_2_diabetic patients .
17441352	0	rosiglitazone	11,24	integrin_beta1	28,42	rosiglitazone	integrin beta1	MESH:C089730	24511(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	-LSB- Effect of rosiglitazone on integrin_beta1 expression and apoptosis of proximal tubular cell exposed to high glucose -RSB- .
17224000	0	rosiglitazone	11,24	interleukin-18	91,105	rosiglitazone	interleukin-18	MESH:C089730	3606	Chemical	Gene	START_ENTITY|dep|decrease decrease|nmod|END_ENTITY	Effects of rosiglitazone and metformin on inflammatory markers and adipokines : decrease in interleukin-18 is an independent factor for the improvement of homeostasis model assessment-beta in type_2_diabetes_mellitus .
19084941	0	rosiglitazone	51,64	interleukin-18	22,36	rosiglitazone	interleukin-18	MESH:C089730	29197(Tax:10116)	Chemical	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Inhibition of hepatic interleukin-18 production by rosiglitazone in a rat model of nonalcoholic_fatty_liver_disease .
17909895	0	rosiglitazone	72,85	leptin	129,135	rosiglitazone	leptin	MESH:C089730	16846(Tax:10090)	Chemical	Gene	levels|amod|START_ENTITY levels|nmod|END_ENTITY	The peroxisome_proliferator_activated_receptor_gamma -LRB- PPARgamma -RRB- ligand rosiglitazone modulates bronchoalveolar lavage levels of leptin , adiponectin , and inflammatory cytokines in lean and obese mice .
21782425	0	rosiglitazone	62,75	mitoNEET	92,100	rosiglitazone	mitoNEET	MESH:C089730	55847	Chemical	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	A novel binding assay identifies high affinity ligands to the rosiglitazone binding site of mitoNEET .
19906946	0	rosiglitazone	113,126	nephrin	16,23	rosiglitazone	nephrin	MESH:C089730	4868	Chemical	Gene	effect|nmod|START_ENTITY expression|dep|effect expression|compound|END_ENTITY	Stretch reduces nephrin expression via an angiotensin_II-AT -LRB- 1 -RRB- - dependent mechanism in human podocytes : effect of rosiglitazone .
16843455	0	rosiglitazone	11,24	paraoxonase-1_and_monocyte_chemoattractant_protein-1	55,107	rosiglitazone	paraoxonase-1 and monocyte chemoattractant protein-1	MESH:C089730	5444;6347	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of rosiglitazone and metformin on postprandial paraoxonase-1_and_monocyte_chemoattractant_protein-1 in human_immunodeficiency_virus-infected patients with lipodystrophy .
20510595	0	rosiglitazone	85,98	peroxisome_proliferator-activated_receptor	25,67	rosiglitazone	peroxisome proliferator-activated receptor	MESH:C089730	5465	Chemical	Gene	effect|dep|START_ENTITY effect|nmod|END_ENTITY	Protective effect of the peroxisome_proliferator-activated_receptor -LRB- PPAR -RRB- - y , ligand rosiglitazone on tert-butyl_hydroperoxide-induced QZG_cell_injury .
11714655	0	rosiglitazone	127,140	peroxisome_proliferator-activated_receptor-gamma	70,118	rosiglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C089730	25664(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|protection protection|nmod|injury injury|nmod|agonist agonist|amod|END_ENTITY	In vivo myocardial protection from ischemia/reperfusion injury by the peroxisome_proliferator-activated_receptor-gamma agonist rosiglitazone .
11815513	0	rosiglitazone	68,81	peroxisome_proliferator-activated_receptor-gamma	10,58	rosiglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C089730	5468	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Synthetic peroxisome_proliferator-activated_receptor-gamma agonist , rosiglitazone , increases plasma levels of adiponectin in type 2 diabetic patients .
14642684	0	rosiglitazone	15,28	peroxisome_proliferator-activated_receptor-gamma	32,80	rosiglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C089730	5468	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	The effects of rosiglitazone , a peroxisome_proliferator-activated_receptor-gamma agonist , on markers of endothelial cell activation , C-reactive_protein , and fibrinogen levels in non-diabetic coronary_artery_disease patients .
15797891	0	rosiglitazone	61,74	peroxisome_proliferator-activated_receptor-gamma	11,59	rosiglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C089730	19016(Tax:10090)	Chemical	Gene	reduces|advmod|START_ENTITY reduces|nsubj|Agonist Agonist|nmod|END_ENTITY	Agonist of peroxisome_proliferator-activated_receptor-gamma , rosiglitazone , reduces renal_injury_and_dysfunction in a murine sepsis model .
16378914	0	rosiglitazone	67,80	peroxisome_proliferator-activated_receptor-gamma	10,58	rosiglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C089730	25664(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|agonist agonist|amod|END_ENTITY	Effect of peroxisome_proliferator-activated_receptor-gamma agonist rosiglitazone on the induction of endometriosis in an experimental rat model .
16539667	0	rosiglitazone	116,129	peroxisome_proliferator-activated_receptor-gamma	59,107	rosiglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C089730	19016(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Neuroprotection Neuroprotection|nmod|ischemic_brain_injury ischemic_brain_injury|nmod|agonist agonist|amod|END_ENTITY	Neuroprotection against focal ischemic_brain_injury by the peroxisome_proliferator-activated_receptor-gamma agonist rosiglitazone .
16609881	0	rosiglitazone	115,128	peroxisome_proliferator-activated_receptor-gamma	58,106	rosiglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C089730	19016(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|receptors receptors|nmod|hepatocytes hepatocytes|nmod|agonist agonist|amod|END_ENTITY	Regulation of adiponectin receptors in hepatocytes by the peroxisome_proliferator-activated_receptor-gamma agonist rosiglitazone .
18387855	0	rosiglitazone	12,25	peroxisome_proliferator-activated_receptor-gamma	34,82	rosiglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C089730	25664(Tax:10116)	Chemical	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	Intrathecal rosiglitazone acts at peroxisome_proliferator-activated_receptor-gamma to rapidly inhibit neuropathic_pain in rats .
20087330	0	rosiglitazone	8,21	peroxisome_proliferator-activated_receptor-gamma	73,121	rosiglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C089730	5468	Chemical	Gene	treatment|compound|START_ENTITY improves|nsubj|treatment improves|advcl|restoring restoring|dobj|activity activity|amod|END_ENTITY	Topical rosiglitazone treatment improves ulcerative_colitis by restoring peroxisome_proliferator-activated_receptor-gamma activity .
21490083	0	rosiglitazone	96,109	peroxisome_proliferator-activated_receptor-gamma	39,87	rosiglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C089730	5468	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|agonist agonist|amod|END_ENTITY	The macrophage-mediated effects of the peroxisome_proliferator-activated_receptor-gamma agonist rosiglitazone attenuate tactile_allodynia in the early phase of neuropathic_pain development .
26099551	0	rosiglitazone	54,67	peroxisome_proliferator-activated_receptor-gamma	71,119	rosiglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C089730	100729138	Chemical	Gene	antioxidant|nmod|START_ENTITY agonists|nsubj|antioxidant agonists|nsubj|END_ENTITY	In-vivo antioxidant and anti-inflammatory activity of rosiglitazone , a peroxisome_proliferator-activated_receptor-gamma -LRB- PPAR-y -RRB- agonists in animal model of bronchial_asthma .
14674008	0	rosiglitazone	90,103	peroxisome_proliferator-activated_receptor_gamma	121,169	rosiglitazone	peroxisome proliferator-activated receptor gamma	MESH:C089730	19016(Tax:10090)	Chemical	Gene	START_ENTITY|appos|ligand ligand|nmod|END_ENTITY	Reduction in the evolution of murine type II collagen-induced_arthritis by treatment with rosiglitazone , a ligand of the peroxisome_proliferator-activated_receptor_gamma .
15640776	0	rosiglitazone	68,81	peroxisome_proliferator-activated_receptor_gamma	10,58	rosiglitazone	peroxisome proliferator-activated receptor gamma	MESH:C089730	5468	Chemical	Gene	Effect|amod|START_ENTITY Effect|nmod|END_ENTITY	Effect of peroxisome_proliferator-activated_receptor_gamma agonist , rosiglitazone , on dedifferentiated thyroid_cancers .
15735429	0	rosiglitazone	60,73	peroxisome_proliferator-activated_receptor_gamma	4,52	rosiglitazone	peroxisome proliferator-activated receptor gamma	MESH:C089730	19016(Tax:10090)	Chemical	Gene	delays|amod|START_ENTITY onset|nsubj|delays ligand|xcomp|onset ligand|nsubj|END_ENTITY	The peroxisome_proliferator-activated_receptor_gamma ligand rosiglitazone delays the onset of inflammatory_bowel_disease in mice with interleukin_10 deficiency .
16321982	0	rosiglitazone	77,90	peroxisome_proliferator-activated_receptor_gamma	123,171	rosiglitazone	peroxisome proliferator-activated receptor gamma	MESH:C089730	5468	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Different residues mediate recognition of 1-O-oleyllysophosphatidic_acid and rosiglitazone in the ligand binding domain of peroxisome_proliferator-activated_receptor_gamma .
16499875	0	rosiglitazone	68,81	peroxisome_proliferator-activated_receptor_gamma	10,58	rosiglitazone	peroxisome proliferator-activated receptor gamma	MESH:C089730	5468	Chemical	Gene	transcription|amod|START_ENTITY agonists|dobj|transcription agonists|nsubj|END_ENTITY	Synthetic peroxisome_proliferator-activated_receptor_gamma agonists rosiglitazone and troglitazone suppress transcription by promoter 3 of the human thromboxane_A2_receptor gene in human erythroleukemia cells .
17122083	0	rosiglitazone	78,91	peroxisome_proliferator-activated_receptor_gamma	14,62	rosiglitazone	peroxisome proliferator-activated receptor gamma	MESH:C089730	5468	Chemical	Gene	components|amod|START_ENTITY Activation|nmod|components Activation|nmod|END_ENTITY	Activation of peroxisome_proliferator-activated_receptor_gamma -LRB- PPARgamma -RRB- by rosiglitazone suppresses components of the insulin-like growth factor regulatory system in vitro and in vivo .
18334011	0	rosiglitazone	117,130	peroxisome_proliferator-activated_receptor_gamma	60,108	rosiglitazone	peroxisome proliferator-activated receptor gamma	MESH:C089730	19016(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|chemoprevention chemoprevention|nmod|endometrial_hyperplasia endometrial_hyperplasia|nmod|agonist agonist|amod|END_ENTITY	Primary chemoprevention of endometrial_hyperplasia with the peroxisome_proliferator-activated_receptor_gamma agonist rosiglitazone in the PTEN heterozygote murine model .
18954260	0	rosiglitazone	10,23	peroxisome_proliferator-activated_receptor_gamma	27,75	rosiglitazone	peroxisome proliferator-activated receptor gamma	MESH:C089730	5468	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effect of rosiglitazone on peroxisome_proliferator-activated_receptor_gamma gene expression in human adipose tissue is limited by antiretroviral drug-induced mitochondrial_dysfunction .
20527969	0	rosiglitazone	244,257	peroxisome_proliferator-activated_receptor_gamma	125,173	rosiglitazone	peroxisome proliferator-activated receptor gamma	MESH:C089730	19016(Tax:10090)	Chemical	Gene	efficacy|nmod|START_ENTITY agonists|nmod|efficacy Design|dep|agonists Design|dep|acids acids|nmod|END_ENTITY	Design , synthesis , and structure-activity relationship studies of novel 2,4,6-trisubstituted-5-pyrimidinecarboxylic _ acids as peroxisome_proliferator-activated_receptor_gamma -LRB- PPARgamma -RRB- partial agonists with comparable antidiabetic efficacy to rosiglitazone .
24304573	0	rosiglitazone	104,117	peroxisome_proliferator-activated_receptor_gamma	46,94	rosiglitazone	peroxisome proliferator-activated receptor gamma	MESH:C089730	25664(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Comparison Comparison|nmod|properties properties|nmod|agonists agonists|amod|END_ENTITY	Comparison of anti-inflammatory properties of peroxisome_proliferator-activated_receptor_gamma agonists rosiglitazone and troglitazone in prophylactic treatment of experimental colitis .
20880548	0	rosiglitazone	86,99	peroxisome_proliferator-activated_receptor_y	12,56	rosiglitazone	peroxisome proliferator-activated receptor y	MESH:C089730	5468	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	The role of peroxisome_proliferator-activated_receptor_y , and effects of its agonist , rosiglitazone , on transient cerebral ischemic_damage .
19902320	0	rosiglitazone	127,140	receptor_for_advanced_glycation_end_products	169,213	rosiglitazone	receptor for advanced glycation end products	MESH:C089730	81722(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Peroxisome_proliferator-activated_receptor-gamma activation attenuates cardiac_fibrosis in type_2_diabetic rats : the effect of rosiglitazone on myocardial expression of receptor_for_advanced_glycation_end_products and of connective_tissue_growth_factor .
15736108	0	rosiglitazone	15,28	resistin	75,83	rosiglitazone	resistin	MESH:C089730	56729	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|concentrations concentrations|nmod|END_ENTITY	The effects of rosiglitazone and metformin on the plasma concentrations of resistin in patients with type_2_diabetes_mellitus .
19778788	0	rosiglitazone	23,36	toll-like_receptor_4	63,83	rosiglitazone	toll-like receptor 4	MESH:C089730	21898(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Inhibitory effects of rosiglitazone on angiotensin_II-induced toll-like_receptor_4 expression and myeloperoxidase activity in RAW264 .7 cells -RSB- .
18239149	0	rosiglitazone	45,58	tumor_necrosis_factor-alpha	73,100	rosiglitazone	tumor necrosis factor-alpha	MESH:C089730	7124	Chemical	Gene	START_ENTITY|dobj|inhibition inhibition|nmod|END_ENTITY	A new mechanism involving ERK contributes to rosiglitazone inhibition of tumor_necrosis_factor-alpha and interferon-gamma inflammatory effects in human endothelial cells .
17235334	0	rosiglitazone	10,23	visfatin	27,35	rosiglitazone	visfatin	MESH:C089730	10135	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|concentrations concentrations|compound|END_ENTITY	Effect of rosiglitazone on visfatin and retinol-binding_protein-4 plasma concentrations in HIV-positive patients .
18942491	0	rosiglitazone	10,23	visfatin	27,35	rosiglitazone	visfatin	MESH:C089730	10135	Chemical	Gene	Impact|nmod|START_ENTITY Impact|nmod|concentrations concentrations|compound|END_ENTITY	Impact of rosiglitazone on visfatin and adiponectin plasma concentrations in patients with type 2 diabetes and coronary_artery_disease .
19815243	0	rosiglitazone	11,24	visfatin	60,68	rosiglitazone	visfatin	MESH:C089730	10135	Chemical	Gene	treatment|compound|START_ENTITY Effects|nmod|treatment Effects|nmod|END_ENTITY	Effects of rosiglitazone and metformin treatment on apelin , visfatin , and ghrelin levels in patients with type_2_diabetes_mellitus .
10353266	0	rosmarinic_acid	51,66	C3b	80,83	rosmarinic acid	C3b	MESH:C041376	718	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of complement by covalent attachment of rosmarinic_acid to activated C3b .
17315853	0	rosmarinic_acid	62,77	Fyn	87,90	rosmarinic acid	Fyn	MESH:C041376	2534	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|compound|END_ENTITY	Homology modeling of human Fyn kinase structure : discovery of rosmarinic_acid as a new Fyn kinase inhibitor and in silico study of its possible binding modes .
26694802	0	rosmarinic_acid	33,48	MDM2	14,18	rosmarinic acid	MDM2	MESH:C041376	17246(Tax:10090)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|expression expression|compound|END_ENTITY	Inhibition of MDM2 expression by rosmarinic_acid in TSLP-stimulated mast cell .
20230877	0	rosmarinic_acid	29,44	prolyl_oligopeptidase	56,77	rosmarinic acid	prolyl oligopeptidase	MESH:C041376	5550	Chemical	Gene	administration|nmod|START_ENTITY administration|appos|inhibitor inhibitor|compound|END_ENTITY	Subchronic administration of rosmarinic_acid , a natural prolyl_oligopeptidase inhibitor , enhances cognitive performances .
20130569	0	rosuvastatin	90,102	ABCG2	0,5	rosuvastatin	ABCG2	MESH:C422923	9429	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|polymorphism polymorphism|compound|END_ENTITY	ABCG2 polymorphism is associated with the low-density lipoprotein cholesterol response to rosuvastatin .
17920365	0	rosuvastatin	31,43	C-reactive_protein	95,113	rosuvastatin	C-reactive protein	MESH:C422923	1401	Chemical	Gene	START_ENTITY|nmod|atorvastatin atorvastatin|nmod|achievement achievement|nmod|END_ENTITY	Comparison of effectiveness of rosuvastatin versus atorvastatin on the achievement of combined C-reactive_protein -LRB- < 2 mg/L -RRB- and low-density lipoprotein cholesterol -LRB- < 70 mg/dl -RRB- targets in patients with type_2_diabetes_mellitus -LRB- from the ANDROMEDA study -RRB- .
20335146	0	rosuvastatin	12,24	C-reactive_protein	106,124	rosuvastatin	C-reactive protein	MESH:C422923	1401	Chemical	Gene	Effects|nmod|START_ENTITY left|nsubj|Effects left|dobj|END_ENTITY	-LSB- Effects of rosuvastatin on left ventricular cardiac function , arteriosclerotic_plaque and high sensitive C-reactive_protein in hypertensive patients with mild LDL-C elevation -RSB- .
20412373	0	rosuvastatin	33,45	C-reactive_protein	0,18	rosuvastatin	C-reactive protein	MESH:C422923	1401	Chemical	Gene	lowering|nmod|START_ENTITY END_ENTITY|acl|lowering	C-reactive_protein lowering with rosuvastatin in the METEOR study .
21641360	0	rosuvastatin	10,22	C-reactive_protein	26,44	rosuvastatin	C-reactive protein	MESH:C422923	1401	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of rosuvastatin on C-reactive_protein and progression of aortic_stenosis .
17270148	0	rosuvastatin	107,119	HMG-CoA-reductase	73,90	rosuvastatin	HMG-CoA-reductase	MESH:C422923	25675(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Improved endothelial function and reduced platelet activation by chronic HMG-CoA-reductase inhibition with rosuvastatin in rats with streptozotocin-induced diabetes_mellitus .
11501230	0	rosuvastatin	23,35	HMG-CoA_reductase	50,67	rosuvastatin	HMG-CoA reductase	MESH:C422923	3156	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Clinical rationale for rosuvastatin , a potent new HMG-CoA_reductase inhibitor .
12238638	0	rosuvastatin	20,32	HMG-CoA_reductase	40,57	rosuvastatin	HMG-CoA reductase	MESH:C422923	3156	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Clinical effects of rosuvastatin , a new HMG-CoA_reductase inhibitor , in Japanese patients with primary hypercholesterolemia : an early phase II study .
12354446	0	rosuvastatin	48,60	HMG-CoA_reductase	68,85	rosuvastatin	HMG-CoA reductase	MESH:C422923	15357(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Direct vascular and cardioprotective effects of rosuvastatin , a new HMG-CoA_reductase inhibitor .
12362926	0	rosuvastatin	54,66	HMG-CoA_reductase	74,91	rosuvastatin	HMG-CoA reductase	MESH:C422923	3156	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY effect|nmod|pharmacokinetics effect|dep|inhibitor inhibitor|amod|END_ENTITY	No effect of age or gender on the pharmacokinetics of rosuvastatin : a new HMG-CoA_reductase inhibitor .
19889690	0	rosuvastatin	26,38	adiponectin	42,53	rosuvastatin	adiponectin	MESH:C422923	9370	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Effect of simvastatin vs. rosuvastatin on adiponectin and haemoglobin A1c levels in patients with non-ischaemic_chronic_heart_failure .
18809153	0	rosuvastatin	11,23	apolipoprotein_B	48,64	rosuvastatin	apolipoprotein B	MESH:C422923	338	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of rosuvastatin and atorvastatin on the apolipoprotein_B / apolipoprotein A-1 ratio in patients with an acute_coronary_syndrome : The CENTAURUS trial design .
20417447	0	rosuvastatin	30,42	apolipoprotein_B	75,91	rosuvastatin	apolipoprotein B	MESH:C422923	338	Chemical	Gene	efficacy|nmod|START_ENTITY Comparison|nmod|efficacy Comparison|nmod|atorvastatin atorvastatin|nmod|END_ENTITY	Comparison of the efficacy of rosuvastatin versus atorvastatin in reducing apolipoprotein_B / apolipoprotein A-1 ratio in patients with acute_coronary_syndrome : results of the CENTAURUS study .
15642550	0	rosuvastatin	23,35	insulin	64,71	rosuvastatin	insulin	MESH:C422923	3630	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Comparative effects of rosuvastatin and gemfibrozil on glucose , insulin , and lipid metabolism in insulin-resistant , nondiabetic patients with combined_dyslipidemia .
16002078	0	rosuvastatin	10,22	insulin	111,118	rosuvastatin	insulin	MESH:C422923	101823595	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|lipoproteins lipoproteins|nmod|model model|nmod|resistance resistance|compound|END_ENTITY	Effect of rosuvastatin on hepatic production of apolipoprotein_B-containing lipoproteins in an animal model of insulin resistance and metabolic_dyslipidemia .
18093597	0	rosuvastatin	10,22	insulin	26,33	rosuvastatin	insulin	MESH:C422923	3630	Chemical	Gene	START_ENTITY|nmod|sensitivity sensitivity|compound|END_ENTITY	Effect of rosuvastatin on insulin sensitivity in an animal model of insulin resistance : evidence for statin-induced hepatic_insulin_sensitization .
18093597	0	rosuvastatin	10,22	insulin	68,75	rosuvastatin	insulin	MESH:C422923	3630	Chemical	Gene	START_ENTITY|nmod|sensitivity sensitivity|nmod|model model|nmod|resistance resistance|compound|END_ENTITY	Effect of rosuvastatin on insulin sensitivity in an animal model of insulin resistance : evidence for statin-induced hepatic_insulin_sensitization .
23113965	0	rosuvastatin	27,39	insulin	90,97	rosuvastatin	insulin	MESH:C422923	3630	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|resistance resistance|compound|END_ENTITY	Effects of manidipine plus rosuvastatin versus olmesartan plus rosuvastatin on markers of insulin resistance in patients with impaired fasting glucose , hypertension , and mixed dyslipidemia .
23113965	0	rosuvastatin	63,75	insulin	90,97	rosuvastatin	insulin	MESH:C422923	3630	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|resistance resistance|compound|END_ENTITY	Effects of manidipine plus rosuvastatin versus olmesartan plus rosuvastatin on markers of insulin resistance in patients with impaired fasting glucose , hypertension , and mixed dyslipidemia .
23170931	0	rosuvastatin	17,29	insulin	93,100	rosuvastatin	insulin	MESH:C422923	3630	Chemical	Gene	mg/day|compound|START_ENTITY mg/day|nsubj|mg/day mg/day|nmod|markers markers|nmod|resistance resistance|compound|END_ENTITY	Colesevelam plus rosuvastatin 5 mg/day versus rosuvastatin 10 mg/day alone on markers of insulin resistance in patients with hypercholesterolemia and impaired_fasting_glucose .
23897788	0	rosuvastatin	11,23	matrix_metalloproteinase-2	60,86	rosuvastatin	matrix metalloproteinase-2	MESH:C422923	81686(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	Effects of rosuvastatin on the production and activation of matrix_metalloproteinase-2 and migration of cultured rat vascular smooth muscle cells induced by homocysteine .
19962701	0	rosuvastatin	11,23	myeloperoxidase	27,42	rosuvastatin	myeloperoxidase	MESH:C422923	4353	Chemical	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	Effects of rosuvastatin on myeloperoxidase levels in patients with chronic_heart_failure : a randomized placebo-controlled study .
17851565	0	rosuvastatin	62,74	organic_anion-transporting_polypeptide_1B1	89,131	rosuvastatin	organic anion-transporting polypeptide 1B1	MESH:C422923	10599	Chemical	Gene	START_ENTITY|appos|substrate substrate|nmod|END_ENTITY	The effect of herbal medicine baicalin on pharmacokinetics of rosuvastatin , substrate of organic_anion-transporting_polypeptide_1B1 .
17692153	0	rosuvastatin	10,22	paraoxonase-1	56,69	rosuvastatin	paraoxonase-1	MESH:C422923	5444	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	Effect of rosuvastatin versus atorvastatin treatment on paraoxonase-1 activity in men with established cardiovascular_disease and a low HDL-cholesterol .
17931620	0	rosuvastatin	10,22	visfatin	43,51	rosuvastatin	visfatin	MESH:C422923	10135	Chemical	Gene	treatment|compound|START_ENTITY Effect|nmod|treatment Effect|nmod|levels levels|compound|END_ENTITY	Effect of rosuvastatin treatment on plasma visfatin levels in patients with primary hyperlipidemia .
10549166	0	rotenone	40,48	AK-5	26,30	rotenone	AK-5	MESH:D012402	26289	Chemical	Gene	cells|nmod|START_ENTITY cells|compound|END_ENTITY	Induction of apoptosis in AK-5 cells by rotenone involves participation of caspases .
23139723	0	rotenone	11,19	inducible_nitric_oxide_synthase	23,54	rotenone	inducible nitric oxide synthase	MESH:D012402	24599(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	Effects of rotenone on inducible_nitric_oxide_synthase and cyclooxygenase-2 mRNA levels detected by real-time PCR in a rat bladder_ischemia / reperfusion model .
26859572	0	rotenone	72,80	mTOR	95,99	rotenone	mTOR	MESH:D012402	21977(Tax:10090)	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Crosstalk between Ca2 + signaling and mitochondrial H2O2 is required for rotenone inhibition of mTOR signaling pathway leading to neuronal apoptosis .
21223980	0	rotenone	96,104	p53	15,18	rotenone	p53	MESH:D012402	7157	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of p53 in cell death following cell cycle arrest and mitotic catastrophe induced by rotenone .
16415913	0	rotigaptide	27,38	connexin_43	144,155	rotigaptide	connexin 43	MESH:C477643	2697	Chemical	Gene	increases|nsubj|START_ENTITY increases|advcl|expressing expressing|dobj|END_ENTITY	The antiarrhythmic peptide rotigaptide -LRB- ZP123 -RRB- increases gap junction intercellular communication in cardiac myocytes and HeLa cells expressing connexin_43 .
16613777	0	rotigaptide	27,38	connexin_43	57,68	rotigaptide	connexin 43	MESH:C477643	24392(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	The antiarrhythmic peptide rotigaptide -LRB- ZP123 -RRB- increases connexin_43 protein expression in neonatal rat ventricular cardiomyocytes .
15922001	0	rottlerin	25,34	PKC_delta	4,13	rottlerin	PKC delta	MESH:C085746	5580	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	The PKC_delta inhibitor , rottlerin , induces apoptosis of haematopoietic cell lines through mitochondrial membrane depolarization and caspases ' cascade .
15232218	5	rottlerin	974,983	PKCdelta	881,889	rottlerin	PKCdelta	MESH:C085746	5580	Chemical	Gene	inhibits|nsubj|START_ENTITY suggesting|ccomp|inhibits affect|advcl|suggesting affect|nsubj|overexpression overexpression|nmod|END_ENTITY	However overexpression of wild type PKCdelta , or a kinase-inactive mutant , did not affect PMA-induction of RANK , suggesting that rottlerin inhibits PMA-induced expression of RANK via a PKCdelta-independent mechanism .
16469949	5	rottlerin	776,785	PKCdelta	755,763	rottlerin	PKCdelta	MESH:C085746	18753(Tax:10090)	Chemical	Gene	adenovirus|amod|START_ENTITY activity|nmod|adenovirus activity|compound|END_ENTITY	Inhibition of PKCdelta activity by rottlerin or dominant-negative adenovirus -LRB- AdPKCdelta DN -RRB- blocked TGFbeta1 's induction of FN , whereas overexpression of PKCdelta enhanced TGFbeta 's effect .
9056675	0	rottlerin	11,20	calmodulin-dependent_protein_kinase_III	38,77	rottlerin	calmodulin-dependent protein kinase III	MESH:C085746	29904	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|inhibitor inhibitor|nmod|END_ENTITY	Effects of rottlerin , an inhibitor of calmodulin-dependent_protein_kinase_III , on cellular proliferation , viability , and cell cycle distribution in malignant_glioma cells .
26142830	0	rovatirelin	10,21	thyrotropin-releasing_Hormone	31,60	rovatirelin	thyrotropin-releasing Hormone	null	7200	Chemical	Gene	START_ENTITY|appos|analog analog|amod|END_ENTITY	Effect of rovatirelin , a novel thyrotropin-releasing_Hormone analog , on the central noradrenergic system .
7904786	0	roxatidine_acetate	49,67	histamine_H2_receptor	16,37	roxatidine acetate	histamine H2 receptor	MESH:C053742	100135540(Tax:10141)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|antagonist antagonist|amod|END_ENTITY	-LSB- Effects of the histamine_H2_receptor antagonist roxatidine_acetate on stomach and liver alcohol dehydrogenase and serum alcohol level -RSB- .
11512277	0	roxindole	36,45	dopamine_D2-receptor	49,69	roxindole	dopamine D2-receptor	MESH:C059613	1813	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	A simple procedure for synthesis of roxindole , a dopamine_D2-receptor agonist .
8776950	0	roxithromycin	23,36	IL-2	57,61	roxithromycin	IL-2	MESH:D015575	3558	Chemical	Gene	START_ENTITY|nmod|induction induction|nmod|END_ENTITY	-LSB- Suppressive effect of roxithromycin on the induction of IL-2 responsiveness by DF-stimulated lymphocytes from patients with bronchial_asthma -RSB- .
8948090	0	roxithromycin	11,24	cytochrome_P450	100,115	roxithromycin	cytochrome P450	MESH:D015575	4051	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|enzymes enzymes|amod|END_ENTITY	Effects of roxithromycin , erythromycin and troleandomycin on their N-demethylation by rat and human cytochrome_P450 enzymes .
19453496	0	roxithromycin	95,108	matrix_metalloproteinase-13	53,80	roxithromycin	matrix metalloproteinase-13	MESH:D015575	4322	Chemical	Gene	involved|nmod|START_ENTITY involved|nmod|inhibition inhibition|nmod|expression expression|amod|END_ENTITY	Runt-related gene 2 is involved in the inhibition of matrix_metalloproteinase-13 expression by roxithromycin in human gingival epithelial cell cultures .
11063386	0	roxithromycin	11,24	vascular_endothelial_growth_factor	64,98	roxithromycin	vascular endothelial growth factor	MESH:D015575	7422	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of roxithromycin on tumor_necrosis_factor-alpha-induced vascular_endothelial_growth_factor expression in human periodontal ligament cells in culture .
197447	0	rubidium	10,18	ATPase	48,54	rubidium	ATPase	MESH:D012413	1769	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of rubidium , lithium and cesium on brain ATPase and protein kinases .
17044810	0	ruboxistaurin	53,66	PKC-beta	33,41	ruboxistaurin	PKC-beta	MESH:C099154	5579	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Clinical safety of the selective PKC-beta inhibitor , ruboxistaurin .
16384948	0	ruboxistaurin	49,62	PKC_beta	14,22	ruboxistaurin	PKC beta	MESH:C099154	5579	Chemical	Gene	administration|nmod|START_ENTITY tolerated|nmod|administration tolerated|nsubjpass|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of PKC_beta by oral administration of ruboxistaurin is well tolerated and ameliorates diabetes-induced retinal_hemodynamic_abnormalities in patients .
18949545	0	ruboxistaurin	35,48	PKC_beta	10,18	ruboxistaurin	PKC beta	MESH:C099154	5579	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Selective PKC_beta inhibition with ruboxistaurin and endothelial function in type-2 diabetes_mellitus .
21892921	0	ruboxistaurin	21,34	PKCb	0,4	ruboxistaurin	PKCb	MESH:C099154	25023(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	PKCb inhibition with ruboxistaurin reduces oxidative stress and attenuates left_ventricular_hypertrophy_and_dysfunction in rats with streptozotocin-induced diabetes .
12624816	0	rutaecarpine	41,53	calcitonin_gene-related_peptide	70,101	rutaecarpine	calcitonin gene-related peptide	MESH:C028632	24241(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY mediated|nsubjpass|effects mediated|nmod|END_ENTITY	The depressor and vasodilator effects of rutaecarpine are mediated by calcitonin_gene-related_peptide .
19018804	0	rutaecarpine	55,67	prolylcarboxypeptidase	15,37	rutaecarpine	prolylcarboxypeptidase	MESH:C028632	293118(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY Involvement|nmod|effect Involvement|nmod|END_ENTITY	Involvement of prolylcarboxypeptidase in the effect of rutaecarpine on the regression of mesenteric artery hypertrophy in renovascular hypertensive rats .
22716220	0	ruthenium_hydride	69,86	CO2	100,103	ruthenium hydride	CO2	null	717	Chemical	Gene	complex|amod|START_ENTITY complex|nmod|END_ENTITY	Mechanistic insight from activation parameters for the reaction of a ruthenium_hydride complex with CO2 in conventional solvents and an ionic liquid .
23837585	0	rutin	51,56	GLUT-4	15,21	rutin	GLUT-4	MESH:D012431	25139(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nmod|effect	Involvement of GLUT-4 in the stimulatory effect of rutin on glucose uptake in rat soleus muscle .
26062544	0	rutin	28,33	IL-6	38,42	rutin	IL-6	MESH:D012431	24498(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Hepato-protective effect of rutin via IL-6 / STAT3 pathway in CCl4-induced hepatotoxicity in rats .
25091621	0	rutin	21,26	MIP-2	83,88	rutin	MIP-2	MESH:D012431	2920	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|compound|END_ENTITY	Protective effect of rutin on LPS-induced acute_lung_injury via down-regulation of MIP-2 expression and MMP-9 activation through inhibition of Akt phosphorylation .
24001577	0	rutin	98,103	Synaptophysin	0,13	rutin	Synaptophysin	MESH:D012431	20977(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY involved|nmod|effect involved|nsubjpass|END_ENTITY	Synaptophysin and the dopaminergic system in hippocampus are involved in the protective effect of rutin against trimethyltin-induced learning_and_memory_impairment .
22292957	0	rutin	48,53	tyrosinase	23,33	rutin	tyrosinase	MESH:D012431	7299	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	An integrated study of tyrosinase inhibition by rutin : progress using a computational simulation .
25975244	0	rutin	22,27	vascular_endothelial_growth_factor	50,84	rutin	vascular endothelial growth factor	MESH:D012431	22339(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Protective effects of rutin through regulation of vascular_endothelial_growth_factor in allergic_rhinitis .
24258498	0	ruxolitinib	19,30	JAK1	40,44	ruxolitinib	JAK1	MESH:C540383	3716	Chemical	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	A phase 2 study of ruxolitinib , an oral JAK1 and JAK2 Inhibitor , in patients with advanced polycythemia vera who are refractory or intolerant to hydroxyurea .
23648912	0	ruxolitinib	43,54	janus_kinase_1	64,78	ruxolitinib	janus kinase 1	MESH:C540383	3716	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	An opportunistic_infection associated with ruxolitinib , a novel janus_kinase_1 ,2 inhibitor .
25957473	0	ryanodine	18,27	Bcl-2	55,60	ryanodine	Bcl-2	MESH:D012433	596	Chemical	Gene	receptor|amod|START_ENTITY receptor|nmod|END_ENTITY	Regulation of the ryanodine receptor by anti-apoptotic Bcl-2 is independent of its BH3-domain-binding properties .
9212592	0	ryanodine	19,28	CA1	52,55	ryanodine	CA1	MESH:D012433	759	Chemical	Gene	reduction|nmod|START_ENTITY END_ENTITY|nsubj|reduction	Rapid reduction in ryanodine binding of hippocampus CA1 in cerebral_ischemia .
18522493	0	ryanodine	44,53	CLIC-2	67,73	ryanodine	CLIC-2	MESH:D012433	1193	Chemical	Gene	receptors|compound|START_ENTITY receptors|nmod|END_ENTITY	Redox potential and the response of cardiac ryanodine receptors to CLIC-2 , a member of the glutathione_S-transferase structural family .
23278119	0	ryanodine	48,57	Dopamine_D1_receptor	0,20	ryanodine	Dopamine D1 receptor	MESH:D012433	13488(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Dopamine_D1_receptor signaling system regulates ryanodine receptor expression in ethanol physical dependence .
19398037	0	ryanodine	43,52	Junctin	0,7	ryanodine	Junctin	MESH:D012433	444	Chemical	Gene	receptors|compound|START_ENTITY activate|dobj|receptors activate|nsubj|END_ENTITY	Junctin and triadin each activate skeletal ryanodine receptors but junctin alone mediates functional interactions with calsequestrin .
12059893	0	ryanodine	26,35	RYR1	53,57	ryanodine	RYR1	MESH:D012433	6261	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mutation screening in the ryanodine receptor 1 gene -LRB- RYR1 -RRB- in patients susceptible to malignant_hyperthermia who show definite IVCT results : identification of three novel mutations .
12364321	0	ryanodine	58,67	RYR1	78,82	ryanodine	RYR1	MESH:D012433	6261	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Suramin interacts with the calmodulin binding site on the ryanodine receptor , RYR1 .
14708096	0	ryanodine	31,40	RYR1	56,60	ryanodine	RYR1	MESH:D012433	6261	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A new mutation in the skeletal ryanodine receptor gene -LRB- RYR1 -RRB- is potentially causative of malignant_hyperthermia , central_core_disease , and severe skeletal_malformation .
25189431	0	ryanodine	63,72	RYR1	88,92	ryanodine	RYR1	MESH:D012433	6261	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Malignant_hyperthermia and the clinical significance of type-1 ryanodine receptor gene -LRB- RYR1 -RRB- variants : proceedings of the 2013 MHAUS Scientific Conference .
27033913	0	ryanodine	15,24	RYR1	35,39	ryanodine	RYR1	MESH:D012433	396718(Tax:9823)	Chemical	Gene	receptor|amod|START_ENTITY effects|nmod|receptor effects|appos|END_ENTITY	The effects of ryanodine receptor -LRB- RYR1 -RRB- mutation on natural killer cell cytotoxicity , plasma cytokines and stress hormones during acute intermittent exercise in pigs .
8203748	0	ryanodine	118,127	RYR1	143,147	ryanodine	RYR1	MESH:D012433	6261	Chemical	Gene	region|amod|START_ENTITY region|appos|END_ENTITY	Application of bacterial artificial chromosomes to the generation of contiguous physical maps : a pilot study of human ryanodine receptor gene -LRB- RYR1 -RRB- region .
20471964	0	ryanodine	46,55	RyR1	73,77	ryanodine	RyR1	MESH:D012433	6261	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Green tea catechins are potent sensitizers of ryanodine receptor type 1 -LRB- RyR1 -RRB- .
20576841	0	ryanodine	62,71	RyR1	106,110	ryanodine	RyR1	MESH:D012433	6261	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Chloroform extract of hog_barn_dust modulates skeletal muscle ryanodine receptor calcium-release channel -LRB- RyR1 -RRB- .
21454501	0	ryanodine	24,33	RyR1	46,50	ryanodine	RyR1	MESH:D012433	6261	Chemical	Gene	START_ENTITY|dobj|interaction interaction|appos|END_ENTITY	Identification of novel ryanodine receptor 1 -LRB- RyR1 -RRB- protein interaction with calcium homeostasis endoplasmic reticulum protein -LRB- CHERP -RRB- .
22007141	1	ryanodine	164,173	RyR1	184,188	ryanodine	RyR1	MESH:D012433	6261	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Imperatoxin A -LRB- IpTx -LRB- a -RRB- -RRB- is known to modify the gating of skeletal ryanodine receptor -LRB- RyR1 -RRB- .
23071115	0	ryanodine	89,98	RyR1	109,113	ryanodine	RyR1	MESH:D012433	6261	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Fluorescence resonance energy transfer -LRB- FRET -RRB- indicates that association with the type I ryanodine receptor -LRB- RyR1 -RRB- causes reorientation of multiple cytoplasmic domains of the dihydropyridine_receptor -LRB- DHPR -RRB- a -LRB- 1S -RRB- subunit .
24819467	0	ryanodine	51,60	RyR1	71,75	ryanodine	RyR1	MESH:D012433	6261	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	CCDI : a new ligand that modulates mammalian type 1 ryanodine receptor -LRB- RyR1 -RRB- .
8670108	1	ryanodine	165,174	RyR1	310,314	ryanodine	RyR1	MESH:D012433	396112(Tax:9031)	Chemical	Gene	isoforms|amod|START_ENTITY relationship|nmod|isoforms define|dobj|relationship cloned|advcl|define cloned|dobj|groups groups|nmod|cDNAs cDNAs|acl|encoding encoding|dobj|homologues homologues|nmod|END_ENTITY	To define the relationship between the two ryanodine receptor -LRB- RyR -RRB- isoforms present in chicken skeletal muscle , we cloned two groups of cDNAs encoding the chicken homologues of mammalian RyR1 and RyR3 .
11157710	0	ryanodine	25,34	RyR2	45,49	ryanodine	RyR2	MESH:D012433	6262	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Mutations of the cardiac ryanodine receptor -LRB- RyR2 -RRB- gene in familial polymorphic ventricular_tachycardia .
16188589	0	ryanodine	35,44	RyR2	55,59	ryanodine	RyR2	MESH:D012433	6262	Chemical	Gene	mutations|amod|START_ENTITY mutations|appos|END_ENTITY	Spectrum and prevalence of cardiac ryanodine receptor -LRB- RyR2 -RRB- mutations in a cohort of unrelated patients referred explicitly for long_QT_syndrome genetic testing .
16249429	0	ryanodine	23,32	RyR2	62,66	ryanodine	RyR2	MESH:D012433	689560(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY diabetes|nmod|receptor Effects|nmod|diabetes release|nsubj|Effects release|dobj|channel channel|appos|END_ENTITY	Effects of diabetes on ryanodine receptor Ca release channel -LRB- RyR2 -RRB- and Ca2 + homeostasis in rat heart .
18045169	0	ryanodine	75,84	RyR2	95,99	ryanodine	RyR2	MESH:D012433	6262	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Developing new anti-arrhythmics : clues from the molecular basis of cardiac ryanodine receptor -LRB- RyR2 -RRB- Ca2 + - release channel_dysfunction .
23354458	0	ryanodine	71,80	RyR2	91,95	ryanodine	RyR2	MESH:D012433	689560(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Malondialdehyde and 4-hydroxynonenal adducts are not formed on cardiac ryanodine receptor -LRB- RyR2 -RRB- and sarco -LRB- endo -RRB- plasmic reticulum Ca2 + - ATPase -LRB- SERCA2 -RRB- in diabetes .
24723656	0	ryanodine	84,93	RyR2	8,12	ryanodine	RyR2	MESH:D012433	6262	Chemical	Gene	phosphorylation|amod|START_ENTITY Controversies|nmod|phosphorylation Role|dep|Controversies Role|nmod|phosphorylation phosphorylation|amod|END_ENTITY	Role of RyR2 phosphorylation in heart_failure and arrhythmias : Controversies around ryanodine receptor phosphorylation in cardiac_disease .
25901278	0	ryanodine	14,23	RyR2	132,136	ryanodine	RyR2	MESH:D012433	6262	Chemical	Gene	RyR2|amod|START_ENTITY Regulation|nmod|RyR2 Regulation|dep|prediction prediction|nmod|site site|nmod|domain domain|nmod|END_ENTITY	Regulation of ryanodine receptor RyR2 by protein-protein interactions : prediction of a PKA binding site on the N-terminal domain of RyR2 and its relation to disease causing mutations .
9148749	0	ryanodine	27,36	RyR2	46,50	ryanodine	RyR2	MESH:D012433	6262	Chemical	Gene	mRNA|amod|START_ENTITY mRNA|compound|END_ENTITY	Differential expression of ryanodine receptor RyR2 mRNA in the non-pregnant and pregnant human myometrium .
11226332	0	ryanodine	78,87	Ryanodine_receptor	0,18	ryanodine	Ryanodine receptor	MESH:D012433	6261	Chemical	Gene	reveals|nmod|START_ENTITY reveals|nsubj|E4032A E4032A|compound|END_ENTITY	Ryanodine_receptor point mutant E4032A reveals an allosteric interaction with ryanodine .
10648886	0	ryanodine	32,41	calreticulin	55,67	ryanodine	calreticulin	MESH:D012433	100381266(Tax:9823)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	The effects of mutated skeletal ryanodine receptors on calreticulin and calsequestrin expression in the brain and pituitary_gland_of_boars .
17709274	0	ryanodine	59,68	presenilin-1	28,40	ryanodine	presenilin-1	MESH:D012433	19164(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	The cytosolic N-terminus of presenilin-1 potentiates mouse ryanodine receptor single channel activity .
14557272	0	ryanodine	123,132	ryanodine_receptor	87,105	ryanodine	ryanodine receptor	MESH:D012433	6262	Chemical	Gene	interaction|amod|START_ENTITY critical|nmod|interaction critical|nsubj|Gln4863 Gln4863|nmod|sequence sequence|nmod|channel channel|appos|END_ENTITY	Residue Gln4863 within a predicted transmembrane sequence of the Ca2 + release channel -LRB- ryanodine_receptor -RRB- is critical for ryanodine interaction .
9174102	0	ryanodine	71,80	ryanodine_receptor	26,44	ryanodine	ryanodine receptor	MESH:D012433	6261	Chemical	Gene	effects|nmod|START_ENTITY effects|amod|END_ENTITY	Conformation state of the ryanodine_receptor and functional effects of ryanodine on skeletal muscle .
7592856	0	ryanodine	39,48	sorcin	15,21	ryanodine	sorcin	MESH:D012433	100751462	Chemical	Gene	receptor|compound|START_ENTITY Association|nmod|receptor Association|nmod|END_ENTITY	Association of sorcin with the cardiac ryanodine receptor .
16954819	0	sabiporide	87,97	NHE-1	114,119	sabiporide	NHE-1	MESH:C476560	6548	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Inhibition of human pulmonary artery smooth muscle cell proliferation and migration by sabiporide , a new specific NHE-1 inhibitor .
22989728	0	sabiporide	43,53	NHE1	22,26	sabiporide	NHE1	MESH:C476560	397458(Tax:9823)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|effects effects|nmod|END_ENTITY	Protective effects of NHE1 inhibition with sabiporide in an experimental model of asphyxia-induced cardiac_arrest in piglets .
21502756	0	saccharated_ferric_oxide	22,46	FGF23	56,61	saccharated ferric oxide	FGF23	null	8074	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of intravenous saccharated_ferric_oxide on serum FGF23 and mineral metabolism in hemodialysis patients .
1933946	0	saccharides	32,43	galaptin	47,55	saccharides	galaptin	CHEBI:16646	3956	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of hydroxylysine-linked saccharides by galaptin , a galactoside-binding animal tissue lectin .
8230105	0	saccharin	68,77	leukocyte_elastase	30,48	saccharin	leukocyte elastase	MESH:D012439	1991	Chemical	Gene	derivatives|compound|START_ENTITY inhibition|nmod|derivatives inhibition|nmod|END_ENTITY	Efficient inhibition of human leukocyte_elastase and cathepsin_G by saccharin derivatives .
15079082	0	saframycin	51,61	GAPDH	18,23	saframycin	GAPDH	null	2597	Chemical	Gene	target|nmod|START_ENTITY END_ENTITY|nmod|target	Identification of GAPDH as a protein target of the saframycin antiproliferative agents .
16624750	0	saikosaponins	11,24	glial_fibrillary_acidic_protein	28,59	saikosaponins	glial fibrillary acidic protein	MESH:C025759	24387(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	-LSB- Effect of saikosaponins on glial_fibrillary_acidic_protein expression in hippocampal astrocytes of pentetrazole-induced chronic kindling rats -RSB- .
18522800	4	sakuranetin	662,673	PPARgamma2	682,692	sakuranetin	PPARgamma2	MESH:C099724	19016(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Time-course analyses indicated that sakuranetin induces PPARgamma2 expression without prior induction of C/EBPbeta , a transcriptional regulator of PPARgamma2 in adipogenesis .
7889288	0	salbutamol	69,79	ANP	59,62	salbutamol	ANP	MESH:D000420	4878	Chemical	Gene	interaction|nmod|START_ENTITY interaction|appos|END_ENTITY	The interaction of alpha-human atrial_natriuretic_peptide -LRB- ANP -RRB- with salbutamol , sodium_nitroprusside and isosorbide_dinitrate in human bronchial smooth muscle .
15081243	0	salbutamol	57,67	IFN-gamma	83,92	salbutamol	IFN-gamma	MESH:D000420	3458	Chemical	Gene	START_ENTITY|nmod|responses responses|compound|END_ENTITY	Tissue specific effects of the beta_2-adrenergic agonist salbutamol on LPS-induced IFN-gamma , IL-10 and TGF-beta responses in vivo .
15133343	0	salbutamol	112,122	P-selectin	26,36	salbutamol	P-selectin	MESH:D000420	6403	Chemical	Gene	levels|nmod|START_ENTITY levels|nmod|END_ENTITY	Decreased serum levels of P-selectin and eosinophil_cationic_protein in patients with mild asthma after inhaled salbutamol .
7889288	0	salbutamol	69,79	atrial_natriuretic_peptide	31,57	salbutamol	atrial natriuretic peptide	MESH:D000420	4878	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	The interaction of alpha-human atrial_natriuretic_peptide -LRB- ANP -RRB- with salbutamol , sodium_nitroprusside and isosorbide_dinitrate in human bronchial smooth muscle .
16420663	0	salbutamol	23,33	beta-2	8,14	salbutamol	beta-2	MESH:D000420	10242	Chemical	Gene	agonist|amod|START_ENTITY agonist|amod|END_ENTITY	Inhaled beta-2 agonist salbutamol and acute_lung_injury : an association with improvement in acute_lung_injury .
21481414	0	salbutamol	23,33	beta-2	8,14	salbutamol	beta-2	MESH:D000420	10242	Chemical	Gene	START_ENTITY|nsubj|agonist agonist|amod|END_ENTITY	Inhaled beta-2 agonist salbutamol for the treatment of transient tachypnea_of_the_newborn .
11772115	0	salbutamol	92,102	beta2-adrenoceptor	13,31	salbutamol	beta2-adrenoceptor	MESH:D000420	154	Chemical	Gene	focus|nmod|START_ENTITY Potential|dep|focus Potential|nmod|agonists agonists|amod|END_ENTITY	Potential of beta2-adrenoceptor agonists as add-on therapy for multiple_sclerosis : focus on salbutamol -LRB- albuterol -RRB- .
12959292	0	salbutamol	86,96	beta2-adrenoceptor	33,51	salbutamol	beta2-adrenoceptor	MESH:D000420	154	Chemical	Gene	responses|nmod|START_ENTITY responses|amod|END_ENTITY	Comparison of the extrapulmonary beta2-adrenoceptor responses and pharmacokinetics of salbutamol given by standard metered dose-inhaler and modified actuator device .
14678347	0	salbutamol	34,44	beta2-adrenoceptor	96,114	salbutamol	beta2-adrenoceptor	MESH:D000420	154	Chemical	Gene	effects|nmod|START_ENTITY homozygous|nsubj|effects homozygous|dobj|haplotypes haplotypes|amod|END_ENTITY	Acute systemic effects of inhaled salbutamol in asthmatic subjects expressing common homozygous beta2-adrenoceptor haplotypes at positions 16 and 27 .
16404139	0	salbutamol	98,108	beta2-adrenoceptor	70,88	salbutamol	beta2-adrenoceptor	MESH:D000420	24176(Tax:10116)	Chemical	Gene	alteration|amod|START_ENTITY alteration|nmod|proteins proteins|nmod|END_ENTITY	Tissue - and dose-dependent alteration of stress-inducible proteins by beta2-adrenoceptor agonist , salbutamol , in rats .
2570601	0	salbutamol	68,78	beta_2-adrenoceptor	104,123	salbutamol	beta 2-adrenoceptor	MESH:D000420	154	Chemical	Gene	Assessment|nmod|START_ENTITY Assessment|nmod|quantification quantification|nmod|blockade blockade|amod|END_ENTITY	Assessment of airways , tremor and chronotropic responses to inhaled salbutamol in the quantification of beta_2-adrenoceptor blockade .
2572036	0	salbutamol	58,68	beta_2-adrenoceptor	18,37	salbutamol	beta 2-adrenoceptor	MESH:D000420	154	Chemical	Gene	agonist|acl|START_ENTITY agonist|amod|END_ENTITY	Broxaterol , a new beta_2-adrenoceptor agonist compared to salbutamol in asthmatics , oral and inhalation treatment .
2575521	0	salbutamol	49,59	beta_2-adrenoceptor	82,101	salbutamol	beta 2-adrenoceptor	MESH:D000420	154	Chemical	Gene	responses|nmod|START_ENTITY Evaluation|nmod|responses Evaluation|nmod|measurement measurement|nmod|blockade blockade|amod|END_ENTITY	Evaluation of the metabolic responses to inhaled salbutamol in the measurement of beta_2-adrenoceptor blockade .
6104976	0	salbutamol	78,88	beta_2-adrenoceptor	49,68	salbutamol	beta 2-adrenoceptor	MESH:D000420	154	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|agonists agonists|amod|END_ENTITY	Metabolic and cardiovascular side effects of the beta_2-adrenoceptor agonists salbutamol and rimiterol .
11985763	0	salbutamol	10,20	erythropoietin	54,68	salbutamol	erythropoietin	MESH:D000420	2056	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|concentration concentration|compound|END_ENTITY	Effect of salbutamol , a beta-2-adrenergic agonist , on erythropoietin concentration in healthy males .
14729655	0	salicylamide	9,21	aryl_hydrocarbon_receptor	46,71	salicylamide	aryl hydrocarbon receptor	MESH:C031060	196	Chemical	Gene	antagonist|nsubj|START_ENTITY antagonist|nmod|END_ENTITY	The drug salicylamide is an antagonist of the aryl_hydrocarbon_receptor that inhibits signal transduction induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin .
6759079	0	salicylate	133,143	Insulin	0,7	salicylate	Insulin	CHEBI:30762	3630	Chemical	Gene	effect|nmod|START_ENTITY responses|dep|effect responses|compound|END_ENTITY	Insulin responses to glucose in non-insulin-dependent diabetic subjects with and without the chlorpropamide-alcohol flush : effect of salicylate and naloxone .
20147414	0	salicylate	10,20	KCNQ4	24,29	salicylate	KCNQ4	CHEBI:30762	100716024	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of salicylate on KCNQ4 of the guinea_pig outer hair cell .
5127332	0	salicylate	15,25	tryptophan_pyrrolase	55,75	salicylate	tryptophan pyrrolase	CHEBI:30762	64206(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nsubj|effects	The effects of salicylate on the activity of rat liver tryptophan_pyrrolase in vitro and in vivo .
9826736	0	salicylates	39,50	erk	59,62	salicylates	erk	MESH:D012459	5594	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|activation activation|compound|END_ENTITY	Modes of action of aspirin-like drugs : salicylates inhibit erk activation and integrin-dependent neutrophil adhesion .
2543361	0	salicylhydroxamic_acid	33,55	myeloperoxidase	14,29	salicylhydroxamic acid	myeloperoxidase	MESH:C005703	4353	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of myeloperoxidase by salicylhydroxamic_acid .
2559945	0	salicylhydroxamic_acid	129,151	myeloperoxidase	8,23	salicylhydroxamic acid	myeloperoxidase	MESH:C005703	4353	Chemical	Gene	studies|nmod|START_ENTITY Role|dep|studies Role|nmod|END_ENTITY	Role of myeloperoxidase in the killing of Staphylococcus_aureus by human neutrophils : studies with the myeloperoxidase inhibitor salicylhydroxamic_acid .
8718890	0	salicylhydroxamic_acid	79,101	myeloperoxidase	117,132	salicylhydroxamic acid	myeloperoxidase	MESH:C005703	4353	Chemical	Gene	START_ENTITY|xcomp|bound bound|nmod|END_ENTITY	2.3 A resolution X-ray crystal structure of the bisubstrate analogue inhibitor salicylhydroxamic_acid bound to human myeloperoxidase : a model for a prereaction complex with hydrogen_peroxide .
20181750	0	salicylic_acid	101,115	AtNUDX6	0,7	salicylic acid	AtNUDX6	MESH:D020156	814985(Tax:3702)	Chemical	Gene	regulates|ccomp|START_ENTITY regulates|nsubj|END_ENTITY	AtNUDX6 , an ADP-ribose/NADH pyrophosphohydrolase in Arabidopsis , positively regulates NPR1-dependent salicylic_acid signaling .
16813576	0	salicylic_acid	35,49	EDS1	102,106	salicylic acid	EDS1	MESH:D020156	823964(Tax:3702)	Chemical	Gene	responses|amod|START_ENTITY responses|nmod|END_ENTITY	Arabidopsis MAP kinase 4 regulates salicylic_acid - and jasmonic_acid / ethylene-dependent responses via EDS1 and PAD4 .
25483988	0	salicylic_acid	12,26	EDS1	40,44	salicylic acid	EDS1	MESH:D020156	823964(Tax:3702)	Chemical	Gene	pathway|amod|START_ENTITY pathway|nmod|END_ENTITY	Evidence of salicylic_acid pathway with EDS1 and PAD4 proteins by molecular dynamics simulation for grape improvement .
12472683	0	salicylic_acid	119,133	RCY1	0,4	salicylic acid	RCY1	MESH:D020156	817183(Tax:3702)	Chemical	Gene	requires|dobj|START_ENTITY requires|nsubj|END_ENTITY	RCY1 , an Arabidopsis_thaliana RPP8/HRT family resistance gene , conferring resistance to cucumber_mosaic_virus requires salicylic_acid , ethylene and a novel signal transduction mechanism .
20560978	0	salicylic_acid	15,29	YopH	47,51	salicylic acid	YopH	MESH:D020156	15151821	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Derivatives of salicylic_acid as inhibitors of YopH in Yersinia_pestis .
582677	0	salicylic_acid	35,49	acetylcholinesterase	62,82	salicylic acid	acetylcholinesterase	MESH:D020156	83817(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	The effect of acetylsalicylic_acid / salicylic_acid mixtures on acetylcholinesterase activity in vitro .
15768982	0	salicylic_acid	42,56	albumin	74,81	salicylic acid	albumin	MESH:D020156	213	Chemical	Gene	-RSB-|amod|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Fluorescence study on the interaction of salicylic_acid and bovine serum albumin -RSB- .
23500715	0	salicylic_acid	52,66	phospholipase_D	15,30	salicylic acid	phospholipase D	MESH:D020156	820816(Tax:3702)	Chemical	Gene	START_ENTITY|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of phospholipase_D and NADPH-oxidase in salicylic_acid signaling cascade .
21711135	0	salidroside	20,31	ovalbumin	82,91	salidroside	ovalbumin	MESH:C009172	282665(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|acl|END_ENTITY	Adjuvant effects of salidroside from Rhodiola rosea L. on the immune responses to ovalbumin in mice .
23339921	0	salidroside	11,22	tumor_necrosis_factor-alpha	53,80	salidroside	tumor necrosis factor-alpha	MESH:C009172	24835(Tax:10116)	Chemical	Gene	pretreatment|amod|START_ENTITY Effects|nmod|pretreatment Effects|nmod|END_ENTITY	Effects of salidroside pretreatment on expression of tumor_necrosis_factor-alpha and permeability of blood brain barrier in rat model of focal_cerebralischemia-reperfusion injury .
20444629	0	salinomycin	41,52	p-glycoprotein	58,72	salinomycin	p-glycoprotein	MESH:C010327	5243	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|amod|END_ENTITY	The cancer stem cell selective inhibitor salinomycin is a p-glycoprotein inhibitor .
9537752	0	salivarium	11,21	interleukin-6	30,43	salivarium	interleukin-6	null	3569	Chemical	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Mycoplasma salivarium induces interleukin-6 and interleukin-8 in human gingival fibroblasts .
12970006	0	salmeterol	63,73	COPD	138,142	salmeterol	COPD	MESH:C057823	260431	Chemical	Gene	combined|nsubj|START_ENTITY combined|nmod|treatment treatment|nmod|END_ENTITY	The efficacy and safety of fluticasone_propionate -LRB- 250 microg -RRB- / salmeterol -LRB- 50 microg -RRB- combined in the Diskus inhaler for the treatment of COPD .
15170026	0	salmeterol	10,20	COPD	89,93	salmeterol	COPD	MESH:C057823	260431	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of salmeterol on respiratory muscle activity during exercise in poorly reversible COPD .
15219176	0	salmeterol	50,60	COPD	117,121	salmeterol	COPD	MESH:C057823	260431	Chemical	Gene	comparison|dep|START_ENTITY albuterol|nsubj|comparison albuterol|nmod|treatment treatment|nmod|END_ENTITY	A short-term comparison of fluticasone_propionate / salmeterol with ipratropium_bromide / albuterol for the treatment of COPD .
18614347	0	salmeterol	33,43	COPD	89,93	salmeterol	COPD	MESH:C057823	260431	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|exacerbations exacerbations|amod|END_ENTITY	Effect of fluticasone_propionate / salmeterol -LRB- 250/50 microg -RRB- or salmeterol -LRB- 50 microg -RRB- on COPD exacerbations .
20631816	0	salmeterol	35,45	COPD	97,101	salmeterol	COPD	MESH:C057823	260431	Chemical	Gene	therapy|amod|START_ENTITY /|dobj|therapy /|advcl|preventing preventing|dobj|exacerbations exacerbations|nmod|END_ENTITY	The role of fluticasone_propionate / salmeterol combination therapy in preventing exacerbations of COPD .
20678680	0	salmeterol	75,85	COPD	194,198	salmeterol	COPD	MESH:C057823	260431	Chemical	Gene	START_ENTITY|nmod|study study|nmod|patients patients|nmod|chronic_obstructive_pulmonary_disease chronic_obstructive_pulmonary_disease|appos|END_ENTITY	Relative effectiveness of budesonide/formoterol and fluticasone_propionate / salmeterol in a 1-year , population-based , matched cohort study of patients with chronic_obstructive_pulmonary_disease -LRB- COPD -RRB- : Effect on COPD-related exacerbations , emergency_department visits and hospitalizations , medication utilization , and treatment adherence .
24461901	0	salmeterol	49,59	COPD	89,93	salmeterol	COPD	MESH:C057823	260431	Chemical	Gene	efficacy|nmod|START_ENTITY polymorphisms|nmod|efficacy Effect|nmod|polymorphisms Effect|acl|preventing preventing|dobj|exacerbations exacerbations|amod|END_ENTITY	Effect of ADRB2 polymorphisms on the efficacy of salmeterol and tiotropium in preventing COPD exacerbations : a prespecified substudy of the POET-COPD trial .
10200132	0	salmeterol	51,61	beta-2	36,42	salmeterol	beta-2	MESH:C057823	10242	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|agonist agonist|amod|END_ENTITY	Cardiac side effects of long-acting beta-2 agonist salmeterol in asthmatic children .
1357550	0	salmeterol	64,74	beta_2-adrenoceptor	35,54	salmeterol	beta 2-adrenoceptor	MESH:C057823	154	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Long-term effects of a long-acting beta_2-adrenoceptor agonist , salmeterol , on airway hyperresponsiveness in patients with mild asthma .
1687365	0	salmeterol	75,85	beta_2-adrenoceptor	47,66	salmeterol	beta 2-adrenoceptor	MESH:C057823	100722663	Chemical	Gene	START_ENTITY|nsubj|Estimation Estimation|nmod|efficacy efficacy|nmod|agonist agonist|amod|END_ENTITY	Estimation of the efficacy and affinity of the beta_2-adrenoceptor agonist salmeterol in guinea-pig trachea .
19594756	0	salmeterol	98,108	beta_2-adrenoceptor	70,89	salmeterol	beta 2-adrenoceptor	MESH:C057823	154	Chemical	Gene	START_ENTITY|nsubj|mechanisms mechanisms|nmod|effect effect|nmod|agonist agonist|amod|END_ENTITY	Molecular mechanisms for the persistent bronchodilatory effect of the beta_2-adrenoceptor agonist salmeterol .
7521712	0	salmeterol	13,23	beta_2-adrenoceptor	39,58	salmeterol	beta 2-adrenoceptor	MESH:C057823	154	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Influence of salmeterol , a long-acting beta_2-adrenoceptor agonist , on IgE-mediated histamine release from human basophils .
8095419	0	salmeterol	99,109	beta_2-adrenoceptor	70,89	salmeterol	beta 2-adrenoceptor	MESH:C057823	24176(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Investigations Investigations|nmod|factors factors|acl|determining determining|dobj|duration duration|nmod|action action|nmod|agonist agonist|amod|END_ENTITY	Investigations into factors determining the duration of action of the beta_2-adrenoceptor agonist , salmeterol .
8622643	0	salmeterol	143,153	beta_2-adrenoceptor	173,192	salmeterol	beta 2-adrenoceptor	MESH:C057823	154	Chemical	Gene	action|nmod|START_ENTITY duration|nmod|action specific|nsubj|duration specific|nmod|END_ENTITY	Comparison of duration of agonist action at beta_1 - and beta_2 - adrenoceptors in C6_glioma cells : evidence that the long duration of action of salmeterol is specific to the beta_2-adrenoceptor .
25921426	0	salmochelin	4,15	IroN	25,29	salmochelin	IroN	null	3853509(Tax:562)	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|nsubj|receptor	The salmochelin receptor IroN itself , but not salmochelin-mediated_iron uptake promotes biofilm formation in extraintestinal pathogenic Escherichia_coli -LRB- ExPEC -RRB- .
24963111	0	salsalate	10,19	insulin	23,30	salsalate	insulin	MESH:C014182	3630	Chemical	Gene	START_ENTITY|nmod|action action|compound|END_ENTITY	Effect of salsalate on insulin action , secretion , and clearance in nondiabetic , insulin-resistant individuals : a randomized , placebo-controlled study .
17976947	0	salsolinol	20,30	prolactin	114,123	salsolinol	prolactin	MESH:C036617	100861193	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|secretion secretion|nmod|END_ENTITY	Interaction between salsolinol -LRB- SAL -RRB- and thyrotropin-releasing hormone -LRB- TRH -RRB- or dopamine -LRB- DA -RRB- on the secretion of prolactin in ruminants .
23323006	0	salvianolate	10,22	zonula_occludens_protein_1	71,97	salvianolate	zonula occludens protein 1	MESH:C561960	292994(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of salvianolate on intestinal epithelium tight junction protein zonula_occludens_protein_1 in cirrhotic rats .
21925853	0	salvianolic_acid_B	112,130	Matrix_metalloproteinase-9	0,26	salvianolic acid B	Matrix metalloproteinase-9	MESH:C076944	4318	Chemical	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Matrix_metalloproteinase-9 induces cardiac fibroblast migration , collagen and cytokine secretion : inhibition by salvianolic_acid_B from Salvia miltiorrhiza .
20083418	0	salvinorin_A	31,43	C-2	18,21	salvinorin A	C-2	MESH:C090499	717	Chemical	Gene	analogs|compound|START_ENTITY analogs|compound|END_ENTITY	CoMFA analyses of C-2 position salvinorin_A analogs at the kappa-opioid_receptor provides insights into epimer selectivity .
16724512	0	salvinorin_A	29,41	kappa-opioid_receptor	66,87	salvinorin A	kappa-opioid receptor	MESH:C090499	4986	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Bioisosteric modification of salvinorin_A , a potent and selective kappa-opioid_receptor agonist .
17951511	0	salvinorin_A	28,40	kappa-opioid_receptor	72,93	salvinorin A	kappa-opioid receptor	MESH:C090499	4986	Chemical	Gene	analog|nmod|START_ENTITY analog|dep|agonist agonist|amod|END_ENTITY	N-methylacetamide analog of salvinorin_A : a highly potent and selective kappa-opioid_receptor agonist with oral efficacy .
18293909	0	salvinorin_A	34,46	kappa-opioid_receptor	66,87	salvinorin A	kappa-opioid receptor	MESH:C090499	4986	Chemical	Gene	recognition|compound|START_ENTITY recognition|nmod|END_ENTITY	Toward a structure-based model of salvinorin_A recognition of the kappa-opioid_receptor .
20083418	0	salvinorin_A	31,43	kappa-opioid_receptor	59,80	salvinorin A	kappa-opioid receptor	MESH:C090499	4986	Chemical	Gene	analogs|compound|START_ENTITY analogs|nmod|END_ENTITY	CoMFA analyses of C-2 position salvinorin_A analogs at the kappa-opioid_receptor provides insights into epimer selectivity .
15658846	0	salvinorin_A	36,48	kappa_opioid_receptor	59,80	salvinorin A	kappa opioid receptor	MESH:C090499	4986	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Studies toward the pharmacophore of salvinorin_A , a potent kappa_opioid_receptor agonist .
16640560	0	salvinorin_A	29,41	kappa_opioid_receptor	61,82	salvinorin A	kappa opioid receptor	MESH:C090499	4986	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	A unique binding epitope for salvinorin_A , a non-nitrogenous kappa_opioid_receptor agonist .
19147366	0	salvinorin_A	34,46	kappa_opioid_receptor	101,122	salvinorin A	kappa opioid receptor	MESH:C090499	4986	Chemical	Gene	ring|nmod|START_ENTITY Modification|nmod|ring Modification|dep|identification identification|nmod|agonist agonist|nmod|END_ENTITY	Modification of the furan ring of salvinorin_A : identification of a selective partial agonist at the kappa_opioid_receptor .
10371365	0	sampatrilat	108,119	angiotensin-converting_enzyme	45,74	sampatrilat	angiotensin-converting enzyme	MESH:C111998	1636	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Sustained antihypertensive actions of a dual angiotensin-converting_enzyme neutral_endopeptidase inhibitor , sampatrilat , in black hypertensive subjects .
10371365	0	sampatrilat	108,119	neutral_endopeptidase	75,96	sampatrilat	neutral endopeptidase	MESH:C111998	4311	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Sustained antihypertensive actions of a dual angiotensin-converting_enzyme neutral_endopeptidase inhibitor , sampatrilat , in black hypertensive subjects .
9797801	0	sampatrilat	82,93	neutral_endopeptidase	23,44	sampatrilat	neutral endopeptidase	MESH:C111998	4311	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Combined inhibition of neutral_endopeptidase and angiotensin-converting_enzyme by sampatrilat in essential hypertension .
12239914	0	sandostatin	12,23	LAR	24,27	sandostatin	LAR	MESH:D015282	5792	Chemical	Gene	role|nmod|START_ENTITY END_ENTITY|nsubj|role	The role of sandostatin LAR in treating patients with advanced hepatocellular_cancer .
2778040	0	sandostatin	11,22	chromogranin-A	33,47	sandostatin	chromogranin-A	MESH:D015282	1113	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|compound|END_ENTITY	Effects of sandostatin on plasma chromogranin-A levels in neuroendocrine_tumors .
11557753	0	sanglifehrin_A	69,83	p53	142,145	sanglifehrin A	p53	MESH:C121329	7157	Chemical	Gene	mediated|nsubjpass|START_ENTITY mediated|nmod|activation activation|nmod|END_ENTITY	Inhibition of cell cycle progression by the novel cyclophilin ligand sanglifehrin_A is mediated through the NFkappa_B-dependent activation of p53 .
11911836	0	sanguiin	11,19	H-6	20,23	sanguiin	H-6	null	3166	Chemical	Gene	Effects|nmod|START_ENTITY Effects|amod|END_ENTITY	Effects of sanguiin H-6 , a component of Sanguisorbae Radix , on lipopolysaccharide-stimulated nitric_oxide production .
8794470	0	sanguinarine	13,25	glutamate_decarboxylase	58,81	sanguinarine	glutamate decarboxylase	MESH:C005705	24957(Tax:10116)	Chemical	Gene	Influence|nmod|START_ENTITY END_ENTITY|nsubj|Influence	Influence of sanguinarine on the GABA synthesizing enzyme glutamate_decarboxylase in vitro .
25299846	0	sanguinarine	54,66	heme_oxygenase-1	15,31	sanguinarine	heme oxygenase-1	MESH:C005705	15368(Tax:10090)	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of heme_oxygenase-1 in neuroprotection by sanguinarine against glutamate-triggered apoptosis in HT22 neuronal cells .
26828288	0	santalin	23,31	tyrosinase	35,45	santalin	tyrosinase	MESH:C030275	22173(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|amod|END_ENTITY	Functionality study of santalin as tyrosinase inhibitor : A potential depigmentation agent .
23185771	0	saponin	34,41	Bax	64,67	saponin	Bax	MESH:D012503	24887(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expressions expressions|nmod|END_ENTITY	-LSB- Effect of qingxin kaiqiao recipe saponin on the expressions of Bax , Bcl-2 , Abeta , and betaAPP in the cortex and hippocampus of Alzheimer 's _ disease rats -RSB- .
17076642	0	saponin	110,117	insulin	82,89	saponin	insulin	MESH:D012503	3630	Chemical	Gene	Isolation|nmod|START_ENTITY Isolation|nmod|END_ENTITY	Isolation , characterization and study of enhancing effects on nasal absorption of insulin in rat of the total saponin from Acanthophyllum squarrosum .
21818973	0	saponins	29,37	APP	41,44	saponins	APP	MESH:D012503	11820(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|transcription transcription|compound|END_ENTITY	-LSB- Effect of Panax notoginseng saponins on APP gene transcription in the brain tissue of SAMP8 -RSB- .
22162298	0	saponins	29,37	CYP1A2	59,65	saponins	CYP1A2	MESH:D012503	24297(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activities activities|nmod|END_ENTITY	Effects of Panax notoginseng saponins on the activities of CYP1A2 , CYP2C9 , CYP2D6 and CYP3A4 in rats in vivo .
9103043	0	saponins	11,19	Carr	40,44	saponins	Carr	MESH:D012503	407	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of saponins from Hedera taurica Carr .
23944037	0	saponins	29,37	MMP-13	56,62	saponins	MMP-13	MESH:D012503	171052(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expressions expressions|nmod|END_ENTITY	-LSB- Effect of Panax notoginseng saponins on expressions of MMP-13 and TIMP-1 in rats with hepatic_fibrosis -RSB- .
25993753	0	saponins	17,25	SDF1	82,86	saponins	SDF1	MESH:D012503	6387	Chemical	Gene	START_ENTITY|nmod|nipponicae nipponicae|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of total saponins from rhizoma dioscoreae nipponicae on the expression of SDF1 and HCIKB kinase in rIK-1beta induced fibroblast-like synoviocytes -RSB- .
25993753	0	saponins	17,25	SDF1	82,86	saponins	SDF1	MESH:D012503	6387	Chemical	Gene	START_ENTITY|nmod|nipponicae nipponicae|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of total saponins from rhizoma dioscoreae nipponicae on the expression of SDF1 and HCIKB kinase in rIK-1beta induced fibroblast-like synoviocytes -RSB- .
16814471	0	saponins	103,111	TNF-alpha	21,30	saponins	TNF-alpha	MESH:D012503	21926(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Mechanism Mechanism|nmod|expression expression|amod|END_ENTITY	Mechanism of altered TNF-alpha expression by macrophage and the modulatory effect of Panax notoginseng saponins in scald mice .
19641779	0	saponins	53,61	TNF-alpha	18,27	saponins	TNF-alpha	MESH:D012503	7124	Chemical	Gene	isolation|nmod|START_ENTITY Saponins|dep|isolation Saponins|nmod|inhibitors inhibitors|amod|END_ENTITY	Saponins as novel TNF-alpha inhibitors : isolation of saponins and a nor-pseudoguaianolide from Parthenium hysterophorus .
16131033	0	saponins	29,37	intercellular_adhesion_molecule-1	41,74	saponins	intercellular adhesion molecule-1	MESH:D012503	25464(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effect of Panax notoginseng saponins on intercellular_adhesion_molecule-1 expression and neutrophil infiltration in cerebral infarction tissue of rats -RSB- .
17498496	0	saponins	30,38	interleukin-1_beta	62,80	saponins	interleukin-1 beta	MESH:D012503	24494(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of Panax notoginseng saponins on mRNA expressions of interleukin-1_beta , its correlative factors and cysteinyl-aspartate specific protease after cerebral_ischemia-reperfusion in rats -RSB- .
20460744	0	saponins	38,46	renin	20,25	saponins	renin	MESH:D012503	5972	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activity activity|compound|END_ENTITY	Inhibition of human renin activity by saponins .
26712211	0	saponins	18,26	silent_information_regulator_1	73,103	saponins	silent information regulator 1	MESH:D012503	309757(Tax:10116)	Chemical	Gene	protect|nsubj|START_ENTITY protect|nmod|END_ENTITY	Panax notoginseng saponins protect kidney from diabetes by up-regulating silent_information_regulator_1 and activating antioxidant proteins in rats .
19673391	0	saponins	29,37	syp	41,44	saponins	syp	MESH:D012503	20977(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	-LSB- Effect of Panax notoginseng saponins on syp and tau gene expression in brain of senescence accelerated mouse -RSB- .
24599820	0	saponins	18,26	vascular_endothelial_growth_factor	91,125	saponins	vascular endothelial growth factor	MESH:D012503	22339(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Panax notoginseng saponins inhibits atherosclerotic_plaque_angiogenesis by down-regulating vascular_endothelial_growth_factor and nicotinamide_adenine_dinucleotide_phosphate_oxidase_subunit_4 expression .
26947206	0	saponins	17,25	vascular_endothelial_growth_factor	78,112	saponins	vascular endothelial growth factor	MESH:D012503	83785(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|Nipponicae Nipponicae|nmod|expression expression|nmod|END_ENTITY	Effects of total saponins from Rhizoma Dioscoreae Nipponicae on expression of vascular_endothelial_growth_factor and angiopoietin-2 and Tie-2 receptors in the synovium of rats with rheumatoid_arthritis .
12126932	0	saposin_C	34,43	beta-glucosidase	71,87	saposin C	beta-glucosidase	MESH:D049231	14466(Tax:10090)	Chemical	Gene	region|amod|START_ENTITY region|nmod|END_ENTITY	Ex vivo localization of the mouse saposin_C activation region for acid beta-glucosidase .
10682127	0	saquinavir	28,38	CD4	148,151	saquinavir	CD4	MESH:D019258	920	Chemical	Gene	outcomes|nmod|START_ENTITY Quality|nmod|outcomes saquinavir|nsubj|Quality saquinavir|nmod|counts counts|nummod|END_ENTITY	Quality of life outcomes of saquinavir , zalcitabine and combination saquinavir plus zalcitabine therapy for adults with advanced HIV_infection with CD4 counts between 50 and 300 cells/mm3 .
10682127	0	saquinavir	68,78	CD4	148,151	saquinavir	CD4	MESH:D019258	920	Chemical	Gene	START_ENTITY|nmod|counts counts|nummod|END_ENTITY	Quality of life outcomes of saquinavir , zalcitabine and combination saquinavir plus zalcitabine therapy for adults with advanced HIV_infection with CD4 counts between 50 and 300 cells/mm3 .
16464744	0	saquinavir	78,88	CD4	108,111	saquinavir	CD4	MESH:D019258	920	Chemical	Gene	START_ENTITY|nmod|response response|nmod|END_ENTITY	Anti-retroviral therapy in HIV-infected patients : in vitro effects of AZT and saquinavir on the response of CD4 and CD8 lymphocytes to interleukin-7 .
23966779	0	saquinavir	61,71	CD4	75,78	saquinavir	CD4	MESH:D019258	920	Chemical	Gene	delivery|nmod|START_ENTITY nanomedicine|nmod|delivery nanomedicine|nmod|cells cells|nummod|+ +|compound|END_ENTITY	Novel intravaginal nanomedicine for the targeted delivery of saquinavir to CD4 + immune cells .
26349060	0	saquinavir	27,37	HMGB1	47,52	saquinavir	HMGB1	MESH:D019258	3146	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	The HIV protease inhibitor saquinavir inhibits HMGB1 driven inflammation by targeting the interaction of cathepsin_V with TLR4/MyD88 .
22293191	0	saquinavir	141,151	MDR1	35,39	saquinavir	MDR1	MESH:D019258	5243	Chemical	Gene	activation|nmod|START_ENTITY activation|nummod|END_ENTITY	High sodium_butyrate levels induce MDR1 activation in colorectal cells : Impact of 15-deoxy - / \ -LRB- 12,14 -RRB- - prostaglandin_J -LRB- 2 -RRB- on the resistance to saquinavir .
15180339	0	saquinavir	50,60	P-glycoprotein	15,29	saquinavir	P-glycoprotein	MESH:D019258	287115(Tax:10116)	Chemical	Gene	transport|nmod|START_ENTITY Involvement|nmod|transport Involvement|nmod|END_ENTITY	Involvement of P-glycoprotein in the transport of saquinavir and indinavir in rat brain microvessel endothelial and microglia cell lines .
15646074	0	saquinavir	115,125	P-glycoprotein	0,14	saquinavir	P-glycoprotein	MESH:D019258	5243	Chemical	Gene	concentration|nmod|START_ENTITY affects|dobj|concentration affects|nsubj|expression expression|amod|END_ENTITY	P-glycoprotein expression affects the intracellular concentration and antiviral activity of the protease inhibitor saquinavir in a T cell line .
18256206	0	saquinavir	94,104	P-glycoprotein	22,36	saquinavir	P-glycoprotein	MESH:D019258	287115(Tax:10116)	Chemical	Gene	absorption|compound|START_ENTITY roles|nmod|absorption roles|nmod|END_ENTITY	Differential roles of P-glycoprotein , multidrug_resistance-associated_protein_2 , and CYP3A on saquinavir oral absorption in Sprague-Dawley_rats .
22611042	0	saquinavir	113,123	P-glycoprotein	27,41	saquinavir	P-glycoprotein	MESH:D019258	287115(Tax:10116)	Chemical	Gene	modification|nmod|START_ENTITY Stereoselective|nmod|modification Stereoselective|dobj|evasion evasion|nmod|END_ENTITY	Stereoselective evasion of P-glycoprotein , cytochrome_P450_3A , and hydrolases by peptide prodrug modification of saquinavir .
23759068	0	saquinavir	25,35	hTERT	45,50	saquinavir	hTERT	MESH:D019258	7015	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	The antiretroviral agent saquinavir enhances hTERT expression and telomerase activity in human T leukaemia cells in vitro .
21855303	0	saquinavir	62,72	ornithine_decarboxylase	14,37	saquinavir	ornithine decarboxylase	MESH:D019258	4953	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of ornithine_decarboxylase during the transport of saquinavir across the blood-brain barrier using composite polymeric nanocarriers under an electromagnetic field .
24145088	0	saquinavir	49,59	protease_inhibitor	29,47	saquinavir	protease inhibitor	MESH:D019258	388007	Chemical	Gene	effects|dep|START_ENTITY effects|nmod|END_ENTITY	Metabolic effects of the HIV protease_inhibitor -- saquinavir in differentiating human preadipocytes .
27095574	0	saracatinib	27,38	SRC	0,3	saracatinib	SRC	MESH:C515233	20779(Tax:10090)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	SRC kinase inhibition with saracatinib limits the development of osteolytic_bone_disease in multiple_myeloma .
20484016	0	saracatinib	51,62	Src	23,26	saracatinib	Src	MESH:C515233	6714	Chemical	Gene	kinase|dobj|START_ENTITY kinase|nsubj|Effect Effect|nmod|family family|compound|END_ENTITY	Effect of the specific Src family kinase inhibitor saracatinib on osteolytic_lesions using the PC-3 bone model .
20682712	0	saracatinib	76,87	Src	101,104	saracatinib	Src	MESH:C515233	6714	Chemical	Gene	activity|nmod|START_ENTITY activity|appos|inhibitor inhibitor|compound|END_ENTITY	Gene array and fluorescence in situ hybridization biomarkers of activity of saracatinib -LRB- AZD0530 -RRB- , a Src inhibitor , in a preclinical model of colorectal_cancer .
21115886	0	saracatinib	28,39	Src	14,17	saracatinib	Src	MESH:C515233	20779(Tax:10090)	Chemical	Gene	model|amod|START_ENTITY inhibitor|dobj|model inhibitor|nsubj|Impact Impact|nmod|END_ENTITY	Impact of the Src inhibitor saracatinib on the metastatic phenotype of a fibrosarcoma -LRB- KHT -RRB- tumor model .
22896656	0	saracatinib	20,31	Src	0,3	saracatinib	Src	MESH:C515233	6714	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|compound|END_ENTITY	Src Inhibition with saracatinib reverses fulvestrant resistance in ER-positive ovarian_cancer models in vitro and in vivo .
23342270	0	saracatinib	92,103	Src	113,116	saracatinib	Src	MESH:C515233	6714	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Biomarker-driven trial in metastatic pancreas_cancer : feasibility in a multicenter study of saracatinib , an oral Src inhibitor , in previously treated pancreatic_cancer .
26009269	0	saracatinib	20,31	Src	45,48	saracatinib	Src	MESH:C515233	6714	Chemical	Gene	study|nmod|START_ENTITY study|appos|inhibitor inhibitor|compound|END_ENTITY	A phase II study of saracatinib -LRB- AZD0530 -RRB- , a Src inhibitor , administered orally daily to patients with advanced thymic malignancies .
24169259	0	saracatinib	20,31	src	49,52	saracatinib	src	MESH:C515233	6714	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|kinases kinases|compound|END_ENTITY	A phase II trial of saracatinib , an inhibitor of src kinases , in previously-treated advanced non-small-cell_lung_cancer : the princess margaret hospital phase II consortium .
2847552	0	saralasin	26,35	ACE	49,52	saralasin	ACE	MESH:D012504	610668(Tax:9615)	Chemical	Gene	START_ENTITY|nmod|effect effect|nmod|END_ENTITY	Resistance to blockade by saralasin of effect of ACE inhibitors in conscious sodium-restricted dog .
8432361	3	saralasin	624,633	ANG_II	658,664	saralasin	ANG II	MESH:D012504	24179(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Previous injections of saralasin -LRB- 10 -LRB- -10 -RRB- M -RRB- , a specific ANG_II antagonist , but not saline vehicle , into the MnPO significantly attenuated the drinking response to ANG_II administration directly into the SFO .
7004740	0	saralasin	103,112	Angiotensin_II	0,14	saralasin	Angiotensin II	MESH:D012504	183	Chemical	Gene	actions|nmod:poss|START_ENTITY balance|nmod|actions determinant|nmod|balance determinant|nsubj|END_ENTITY	Angiotensin_II and not sodium status is the major determinant of the agonistic/antagonistic balance of saralasin 's actions .
7018793	0	saralasin	84,93	Angiotensin_II	0,14	saralasin	Angiotensin II	MESH:D012504	183	Chemical	Gene	actions|nmod:poss|START_ENTITY balance|nmod|actions END_ENTITY|dep|balance	Angiotensin_II and sodium as determinants of the agonistic -- antagonistic balance of saralasin 's actions .
1019166	0	saralasin	45,54	angiotensin_II	140,154	saralasin	angiotensin II	MESH:D012504	183	Chemical	Gene	effects|nmod|START_ENTITY aldosterone|nsubj|effects aldosterone|nmod|concentration concentration|compound|END_ENTITY	The effects of the angiotensin_II antagonist saralasin on blood pressure and plasma aldosterone in man in relation to the prevailing plasma angiotensin_II concentration .
1071403	0	saralasin	15,24	angiotensin_II	29,43	saralasin	angiotensin II	MESH:D012504	183	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	The effects of saralasin , an angiotensin_II antagonist , on blood pressure and the renin-angiotensin-aldosterone system in normal and hypertensive subjects .
19645	0	saralasin	54,63	angiotensin_II	27,41	saralasin	angiotensin II	MESH:D012504	183	Chemical	Gene	-RSB-|amod|START_ENTITY changes|nmod|-RSB- changes|nmod|blockade blockade|amod|END_ENTITY	-LSB- Hemodynamic changes after angiotensin_II blockade by saralasin -LRB- author 's transl -RRB- -RSB- .
235090	0	saralasin	37,46	angiotensin_II	10,24	saralasin	angiotensin II	MESH:D012504	183	Chemical	Gene	Use|appos|START_ENTITY Use|nmod|antagonist antagonist|amod|END_ENTITY	Use of an angiotensin_II antagonist -LRB- saralasin -RRB- in the recognition of `` angiotensinogenic '' hypertension ; .
3521046	0	saralasin	37,46	angiotensin_II	15,29	saralasin	angiotensin II	MESH:D012504	183	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|analog analog|amod|END_ENTITY	-LSB- Effect of the angiotensin_II analog saralasin before donor nephrectomy on primary transplant function -RSB- .
4079591	1	saralasin	94,103	angiotensin_II	74,88	saralasin	angiotensin II	MESH:D012504	24179(Tax:10116)	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	I. Interaction of angiotensin_II with saralasin .
455738	0	saralasin	40,49	angiotensin_II	14,28	saralasin	angiotensin II	MESH:D012504	183	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|antagonist antagonist|amod|END_ENTITY	Effect of the angiotensin_II antagonist saralasin on plasma aldosterone concentration and on blood pressure before and during sodium depletion in normal subjects .
600326	0	saralasin	52,61	angiotensin_II	26,40	saralasin	angiotensin II	MESH:D012504	24179(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Action Action|nmod|antagonist antagonist|compound|END_ENTITY	Action of the competitive angiotensin_II antagonist saralasin during the initial phase of glycerol-induced acute_renal_failure of the rat .
6168855	0	saralasin	80,89	angiotensin_II	51,65	saralasin	angiotensin II	MESH:D012504	183	Chemical	Gene	Systemic|nmod|START_ENTITY Systemic|nmod|blockade blockade|amod|END_ENTITY	Systemic hemodynamic and hormonal responses during angiotensin_II blockade with saralasin .
6306220	0	saralasin	37,46	angiotensin_II	92,106	saralasin	angiotensin II	MESH:D012504	24179(Tax:10116)	Chemical	Gene	produce|nsubj|START_ENTITY produce|dobj|blockade blockade|nmod|receptors receptors|compound|END_ENTITY	Will chronic intracerebroventricular saralasin infusion produce selective blockade of brain angiotensin_II receptors in the rat ?
6349037	0	saralasin	47,56	angiotensin_II	20,34	saralasin	angiotensin II	MESH:D012504	183	Chemical	Gene	influence|acl|START_ENTITY influence|nmod|antagonist antagonist|amod|END_ENTITY	The influence of an angiotensin_II antagonist , saralasin , given before donor nephrectomy , on kidney function after transplantation .
7020064	0	saralasin	41,50	angiotensin_II	14,28	saralasin	angiotensin II	MESH:D012504	183	Chemical	Gene	use|appos|START_ENTITY use|nmod|antagonist antagonist|amod|END_ENTITY	The use of an angiotensin_II antagonist -LRB- saralasin -RRB- as an adjunct during renal vein catheterization .
732257	0	saralasin	98,107	angiotensin_II	82,96	saralasin	angiotensin II	MESH:D012504	183	Chemical	Gene	Val5|dep|START_ENTITY Val5|appos|END_ENTITY	Pharmacokinetic and pharmacodynamic studies of infusions with -LSB- Sar_1 , Val5 , Ala8 -RSB- angiotensin_II -LRB- saralasin -RRB- .
874056	0	saralasin	38,47	angiotensin_II	11,25	saralasin	angiotensin II	MESH:D012504	183	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|blockade blockade|amod|END_ENTITY	Effects of angiotensin_II blockade by saralasin in normal man .
1020762	0	saralasin	30,39	renin	106,111	saralasin	renin	MESH:D012504	5972	Chemical	Gene	Usefulness|nmod|START_ENTITY Usefulness|acl|evaluating evaluating|dobj|factors factors|compound|END_ENTITY	Usefulness and limitations of saralasin , a partial competitive agonist of angioten II , for evaluating the renin and sodium factors in hypertensive patients .
1053323	0	saralasin	40,49	renin	62,67	saralasin	renin	MESH:D012504	5972	Chemical	Gene	test|compound|START_ENTITY test|nmod|determinations determinations|compound|END_ENTITY	Detection of renovascular_hypertension : saralasin test versus renin determinations .
185903	0	saralasin	96,105	renin	11,16	saralasin	renin	MESH:D012504	5972	Chemical	Gene	converting|nmod|START_ENTITY superiority|acl|converting participation|dep|superiority participation|compound|END_ENTITY	Estimating renin participation in hypertension : superiority of converting enzyme inhibitor over saralasin .
682528	0	saralasin	11,20	renin	31,36	saralasin	renin	MESH:D012504	5972	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	-LSB- Effect of saralasin on plasma renin activity and arginine-vasopressin in patients with angiotensin-dependent hypertension -LRB- author 's transl -RRB- -RSB- .
7001167	0	saralasin	11,20	renin	47,52	saralasin	renin	MESH:D012504	5972	Chemical	Gene	START_ENTITY|nmod|pressure pressure|appos|END_ENTITY	-LSB- Effect of saralasin on blood pressure , plasma renin and plasma noradrenaline in hypertensive patients -RSB- .
740674	0	saralasin	10,19	renin	30,35	saralasin	renin	MESH:D012504	5972	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of saralasin on plasma renin activity and arginine-vasopressin in hypertensive man .
17321042	0	sarcophine-diol	27,42	CD-1	72,76	sarcophine-diol	CD-1	MESH:C573078	111334(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|mice mice|compound|END_ENTITY	Chemopreventive effects of sarcophine-diol on skin_tumor development in CD-1 mice .
10966517	0	sarin	6,11	acetylcholinesterase	82,102	sarin	acetylcholinesterase	MESH:D012524	83817(Tax:10116)	Chemical	Gene	exposure|compound|START_ENTITY causes|nsubj|exposure causes|dobj|regulation regulation|nmod|END_ENTITY	Acute sarin exposure causes differential regulation of choline acetyltransferase , acetylcholinesterase , and acetylcholine receptors in the central nervous system of the rat .
12604711	0	sarin	125,130	acetylcholinesterase	82,102	sarin	acetylcholinesterase	MESH:D012524	83817(Tax:10116)	Chemical	Gene	affects|nmod|START_ENTITY affects|dobj|inactivation inactivation|nmod|END_ENTITY	Adenosine A1 receptor agonist N6-cyclopentyladenosine affects the inactivation of acetylcholinesterase in blood and brain by sarin .
16025528	0	sarin	80,85	acetylcholinesterase	38,58	sarin	acetylcholinesterase	MESH:D012524	83817(Tax:10116)	Chemical	Gene	reactivators|nmod|START_ENTITY reactivators|nsubj|potency potency|nmod|END_ENTITY	In vitro reactivation potency of some acetylcholinesterase reactivators against sarin - and cyclosarin-induced inhibitions .
16119250	0	sarin	69,74	acetylcholinesterase	11,31	sarin	acetylcholinesterase	MESH:D012524	83817(Tax:10116)	Chemical	Gene	vapors|compound|START_ENTITY exposure|nmod|vapors Changes|nmod|exposure Changes|nmod|activity activity|amod|END_ENTITY	Changes of acetylcholinesterase activity after long-term exposure to sarin vapors in rats .
16821887	0	sarin	47,52	acetylcholinesterase	12,32	sarin	acetylcholinesterase	MESH:D012524	43	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Probing the acetylcholinesterase inhibition of sarin : a comparative interaction study of the inhibitor and acetylcholine with a model enzyme cavity .
16904809	0	sarin	42,47	acetylcholinesterase	78,98	sarin	acetylcholinesterase	MESH:D012524	43	Chemical	Gene	investigation|nmod|START_ENTITY analogues|nsubj|investigation analogues|xcomp|reacting reacting|nmod|END_ENTITY	Enzyme-kinetic investigation of different sarin analogues reacting with human acetylcholinesterase and butyrylcholinesterase .
17096183	0	sarin	116,121	acetylcholinesterase	68,88	sarin	acetylcholinesterase	MESH:D012524	43	Chemical	Gene	isopropyl_p-nitrophenyl_methylphosphonate|amod|START_ENTITY using|dobj|isopropyl_p-nitrophenyl_methylphosphonate END_ENTITY|xcomp|using	New safe method for preparation of sarin-exposed human erythrocytes acetylcholinesterase using non-toxic and stable sarin analogue isopropyl_p-nitrophenyl_methylphosphonate and its application to evaluation of nerve agent antidotes .
18396355	0	sarin	25,30	acetylcholinesterase	54,74	sarin	acetylcholinesterase	MESH:D012524	43	Chemical	Gene	regeneration|nmod|START_ENTITY inhibited|nsubj|regeneration inhibited|dobj|END_ENTITY	In-vitro regeneration of sarin inhibited electric eel acetylcholinesterase by bis-pyridinium_oximes bearing xylene linker .
18645722	0	sarin	118,123	acetylcholinesterase	39,59	sarin	acetylcholinesterase	MESH:D012524	100422792	Chemical	Gene	exposure|nmod|START_ENTITY levels|nmod|exposure levels|compound|END_ENTITY	Blood and bronchoalveolar lavage fluid acetylcholinesterase levels following microinstillation inhalation exposure to sarin in Guinea_pigs .
19283689	0	sarin	126,131	acetylcholinesterase	32,52	sarin	acetylcholinesterase	MESH:D012524	83817(Tax:10116)	Chemical	Gene	physostigmine|amod|START_ENTITY expression|nmod|physostigmine expression|nmod|END_ENTITY	Differential mRNA expression of acetylcholinesterase in the central nervous system of rats with acute and chronic exposure of sarin _ physostigmine .
20105433	0	sarin	46,51	acetylcholinesterase	83,103	sarin	acetylcholinesterase	MESH:D012524	43	Chemical	Gene	interactions|nmod|START_ENTITY interactions|nmod|END_ENTITY	Kinetic analysis of interactions of different sarin and tabun analogues with human acetylcholinesterase and oximes : is there a structure-activity relationship ?
20227400	0	sarin	111,116	acetylcholinesterase	17,37	sarin	acetylcholinesterase	MESH:D012524	100422792	Chemical	Gene	exposure|nmod|START_ENTITY activity|nmod|exposure END_ENTITY|dobj|activity	Gastrointestinal acetylcholinesterase activity following endotracheal microinstillation inhalation exposure to sarin in guinea_pigs .
21745562	0	sarin	136,141	acetylcholinesterase	90,110	sarin	acetylcholinesterase	MESH:D012524	43	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubj|potency potency|nmod|bis-pyridinium_oximes bis-pyridinium_oximes|nmod|END_ENTITY	In vitro reactivation potency of novel symmetrical bis-pyridinium_oximes for electric eel acetylcholinesterase inhibited by nerve agent sarin .
24443939	0	sarin	92,97	acetylcholinesterase	125,145	sarin	acetylcholinesterase	MESH:D012524	43	Chemical	Gene	inactivated|nsubj|START_ENTITY inactivated|xcomp|END_ENTITY	Exploring the physicochemical properties of oxime-reactivation therapeutics for cyclosarin , sarin , tabun , and VX inactivated acetylcholinesterase .
3945161	0	sarin	74,79	acetylcholinesterase	83,103	sarin	acetylcholinesterase	MESH:D012524	43	Chemical	Gene	inhibition|nmod|START_ENTITY Protection|nmod|inhibition Protection|nmod|activity activity|amod|END_ENTITY	Protection from quinidine or physostigmine against in vitro inhibition by sarin of acetylcholinesterase activity .
7463067	0	sarin	195,200	acetylcholinesterase	92,112	sarin	acetylcholinesterase	MESH:D012524	83817(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of selective alkylphosphorylation of propionylcholinesterase on the regeneration of acetylcholinesterase in the aqueous soluble fraction of superior cervical ganglia of the rat following sarin .
9481881	0	sarin	84,89	acetylcholinesterase	37,57	sarin	acetylcholinesterase	MESH:D012524	83817(Tax:10116)	Chemical	Gene	intoxication|compound|START_ENTITY forms|nmod|intoxication END_ENTITY|dobj|forms	Differential inhibition of the brain acetylcholinesterase molecular forms following sarin , soman and VX intoxication in laboratory_rats .
21329748	0	sarin	43,48	paraoxonase_1	12,25	sarin	paraoxonase 1	MESH:D012524	100721268	Chemical	Gene	toxicity|compound|START_ENTITY protects|nmod|toxicity protects|nsubj|END_ENTITY	Recombinant paraoxonase_1 protects against sarin and soman toxicity following microinstillation inhalation exposure in guinea_pigs .
16229932	0	sarizotan	40,49	5-HT1A	51,57	sarizotan	5-HT1A	MESH:C443959	24473(Tax:10116)	Chemical	Gene	administration|nmod|START_ENTITY effect|nmod|administration effect|appos|agonist/D3/D4 agonist/D3/D4|nummod|END_ENTITY	The effect of chronic administration of sarizotan , 5-HT1A agonist/D3/D4 ligand , on haloperidol-induced repetitive jaw_movements in rat model of tardive_dyskinesia .
17031071	0	sarpogrelate	28,40	5-HT2A-receptor	54,69	sarpogrelate	5-HT2A-receptor	MESH:C064294	3356	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Inverse agonist activity of sarpogrelate , a selective 5-HT2A-receptor antagonist , at the constitutively active human 5-HT2A_receptor .
17031071	0	sarpogrelate	28,40	5-HT2A_receptor	117,132	sarpogrelate	5-HT2A receptor	MESH:C064294	3356	Chemical	Gene	activity|nmod|START_ENTITY activity|nmod|END_ENTITY	Inverse agonist activity of sarpogrelate , a selective 5-HT2A-receptor antagonist , at the constitutively active human 5-HT2A_receptor .
22975508	0	sarpogrelate	39,51	5-HT2A_receptor	97,112	sarpogrelate	5-HT2A receptor	MESH:C064294	3356	Chemical	Gene	START_ENTITY|nmod|mutant mutant|nmod|END_ENTITY	Mechanism of inverse agonist action of sarpogrelate at the constitutively active mutant of human 5-HT2A_receptor revealed by molecular modeling .
8987165	0	sarpogrelate	41,53	5HT2_receptor	16,29	sarpogrelate	5HT2 receptor	MESH:C064294	3356	Chemical	Gene	treatment|amod|START_ENTITY treatment|amod|END_ENTITY	The effect of a 5HT2_receptor antagonist sarpogrelate -LRB- MCI-9042 -RRB- treatment on platelet function in Buerger 's _ disease .
25268386	0	sarpogrelate	38,50	CYP2D6	21,27	sarpogrelate	CYP2D6	MESH:C064294	1565	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|inhibitor inhibitor|compound|END_ENTITY	Effect of the potent CYP2D6 inhibitor sarpogrelate on the pharmacokinetics and pharmacodynamics of metoprolol in healthy male Korean volunteers .
20799047	0	sarpogrelate_hydrochloride	33,59	5-HT2_receptor	85,99	sarpogrelate hydrochloride	5-HT2 receptor	null	3356	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|antagonist antagonist|amod|END_ENTITY	Erythrocyte-protective effect of sarpogrelate_hydrochloride -LRB- Anplag -RRB- , a selective 5-HT2_receptor antagonist : an in vitro study .
20214903	0	sarsasapogenin	41,55	CREB	8,12	sarsasapogenin	CREB	MESH:C046297	1385	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of CREB in the regulatory action of sarsasapogenin on muscarinic M1 receptor density during cell aging .
21608017	0	sasanquasaponin	34,49	Anion_exchanger_3	0,17	sasanquasaponin	Anion exchanger 3	MESH:C497504	6508	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Anion_exchanger_3 is required for sasanquasaponin to inhibit ischemia/reperfusion-induced elevation of intracellular Cl - concentration and to elicit cardioprotection .
12037735	0	saturated_and_unsaturated_fatty_acids	34,71	insulin	23,30	saturated and unsaturated fatty acids	insulin	null	3630	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Differential effect of insulin on saturated_and_unsaturated_fatty_acids .
7094889	0	sauvagine	61,70	prolactin	28,37	sauvagine	prolactin	MESH:C025727	24683(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Potent in vivo and in vitro prolactin inhibiting activity of sauvagine , a frog skin peptide .
19929711	0	saxagliptin	52,63	DPP-4	19,24	saxagliptin	DPP-4	MESH:C502994	1803	Chemical	Gene	focus|nmod|START_ENTITY inhibitors|nmod|focus inhibitors|nsubj|Exploration Exploration|nmod|END_ENTITY	Exploration of the DPP-4 inhibitors with a focus on saxagliptin .
22932707	0	saxagliptin	39,50	Dipeptidyl_peptidase-4	0,22	saxagliptin	Dipeptidyl peptidase-4	MESH:C502994	25253(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Dipeptidyl_peptidase-4 inhibition with saxagliptin enhanced nitric_oxide release and reduced blood pressure and sICAM-1 levels in hypertensive rats .
24163113	0	saxagliptin	80,91	Dipeptidyl_peptidase-4	0,22	saxagliptin	Dipeptidyl peptidase-4	MESH:C502994	1803	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|inhibition inhibition|amod|END_ENTITY	Dipeptidyl_peptidase-4 inhibition in patients with type 2 diabetes treated with saxagliptin , sitagliptin , or vildagliptin .
18355324	0	saxagliptin	66,77	dipeptidyl_peptidase-4	33,55	saxagliptin	dipeptidyl peptidase-4	MESH:C502994	1803	Chemical	Gene	START_ENTITY|nsubj|activity activity|nmod|inhibitor inhibitor|amod|END_ENTITY	Glucose-lowering activity of the dipeptidyl_peptidase-4 inhibitor saxagliptin in drug-naive patients with type 2 diabetes .
21651615	0	saxagliptin	69,80	dipeptidyl_peptidase-4	84,106	saxagliptin	dipeptidyl peptidase-4	MESH:C502994	1803	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effect of rifampicin on the pharmacokinetics and pharmacodynamics of saxagliptin , a dipeptidyl_peptidase-4 inhibitor , in healthy subjects .
25936515	0	saxagliptin	87,98	dipeptidyl_peptidase-4	23,45	saxagliptin	dipeptidyl peptidase-4	MESH:C502994	25253(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|role role|nmod|END_ENTITY	Critical role of renal dipeptidyl_peptidase-4 in ameliorating kidney_injury induced by saxagliptin in Dahl salt-sensitive hypertensive rats .
27063445	0	saxagliptin	94,105	dipeptidyl_peptidase-4	60,82	saxagliptin	dipeptidyl peptidase-4	MESH:C502994	25253(Tax:10116)	Chemical	Gene	mechanisms|acl|START_ENTITY mechanisms|amod|inhibitor inhibitor|amod|END_ENTITY	Glucose-independent renoprotective mechanisms of the tissue dipeptidyl_peptidase-4 inhibitor , saxagliptin , in Dahl salt-sensitive hypertensive rats .
16364232	0	saxagliptin	93,104	dipeptidyl_peptidase-IV	47,70	saxagliptin	dipeptidyl peptidase-IV	MESH:C502994	1803	Chemical	Gene	catalyzed|nmod|START_ENTITY catalyzed|nmod|END_ENTITY	Mechanism of Gly-Pro-pNA cleavage catalyzed by dipeptidyl_peptidase-IV and its inhibition by saxagliptin -LRB- BMS-477118 -RRB- .
19251818	0	saxagliptin	57,68	dipeptidyl_peptidase_4	24,46	saxagliptin	dipeptidyl peptidase 4	MESH:C502994	25253(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Pharmacokinetics Pharmacokinetics|nmod|inhibitor inhibitor|amod|END_ENTITY	Pharmacokinetics of the dipeptidyl_peptidase_4 inhibitor saxagliptin in rats , dogs , and monkeys and clinical projections .
8621395	0	schiff_base	2,13	P-selectin	86,96	schiff base	P-selectin	MESH:D012545	6403	Chemical	Gene	stabilizes|nsubj|START_ENTITY stabilizes|xcomp|END_ENTITY	A schiff_base with mildly oxidized_carbohydrate ligands stabilizes L-selectin and not P-selectin or E-selectin rolling adhesions in shear flow .
20448858	0	schisandrin_A	22,35	CYP3A	57,62	schisandrin A	CYP3A	MESH:C034734	170509(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activity activity|compound|END_ENTITY	Inhibitory effects of schisandrin_A and schisandrin_B on CYP3A activity .
22906632	0	schizandrin	11,22	thymic_stromal_lymphopoietin	44,72	schizandrin	thymic stromal lymphopoietin	MESH:C011105	85480	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of schizandrin on the expression of thymic_stromal_lymphopoietin in human mast cell line HMC-1 .
17350296	0	scopolamine	98,109	CA3	150,153	scopolamine	CA3	MESH:D012601	54232(Tax:10116)	Chemical	Gene	infusions|amod|START_ENTITY infusions|nmod|END_ENTITY	Behavioral characterization of a transection of dorsal CA3 subcortical efferents : comparison with scopolamine and physostigmine infusions into dorsal CA3 .
9296567	0	scopolamine	32,43	HSP70	90,95	scopolamine	HSP70	MESH:D012601	266759(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nsubj|effects	Regionally different effects of scopolamine on NMDA antagonist-induced heat_shock protein HSP70 .
2849408	0	scopolamine	86,97	beta-endorphin	34,48	scopolamine	beta-endorphin	MESH:D012601	18976(Tax:10090)	Chemical	Gene	enhancement|nmod|START_ENTITY enhancement|nmod|END_ENTITY	Retention enhancement by pre-test beta-endorphin and oxotremorine and its reversal by scopolamine .
11223008	0	scopolamine	23,34	fos	66,69	scopolamine	fos	MESH:D012601	314322(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Comparative effects of scopolamine and quinpirole on the striatal fos expression induced by stimulation of D -LRB- 1 -RRB- dopamine receptors in the rat .
1986031	0	scopolamine	26,37	growth_hormone	51,65	scopolamine	growth hormone	MESH:D012601	2688	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Dose-dependent effects of scopolamine on nocturnal growth_hormone secretion in normal adult men : relation to delta-sleep changes .
11371021	0	scopoletin	11,21	cytochrome_c	113,125	scopoletin	cytochrome c	MESH:D012603	104968582	Chemical	Gene	Effects|nmod|START_ENTITY Effects|dep|END_ENTITY	Effects of scopoletin and aflatoxin_B1 on bovine hepatic mitochondrial respiratory complexes , 2 : a-ketoglutarate cytochrome_c and succinate cytochrome_c reductases .
17786283	0	scopoletin	10,20	lipoprotein_lipase	24,42	scopoletin	lipoprotein lipase	MESH:D012603	4023	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	Effect of scopoletin on lipoprotein_lipase activity in 3T3-L1 adipocytes .
15566295	0	scopolin	44,52	Acetylcholinesterase	0,20	scopolin	Acetylcholinesterase	MESH:C417572	83817(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Acetylcholinesterase inhibitory activity of scopolin and scopoletin discovered by virtual screening of natural products .
25073400	0	scutellarin	19,30	CYP1A2	52,58	scutellarin	CYP1A2	MESH:C484876	24297(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activities activities|nmod|END_ENTITY	In vivo effects of scutellarin on the activities of CYP1A2 , CYP2C11 , CYP2D1 , and CYP3A1/2 by cocktail probe drugs in rats .
21655064	0	scutellarin	11,22	MUC5AC	26,32	scutellarin	MUC5AC	MESH:C484876	4586	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Effects of scutellarin on MUC5AC mucin production induced by human neutrophil elastase or interleukin_13 on airway epithelial cells .
17883942	0	scutellarin	11,22	PKCgamma	26,34	scutellarin	PKCgamma	MESH:C484876	24681(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of scutellarin on PKCgamma in PC12 cell injury induced by oxygen and glucose deprivation .
21672380	0	scutellarin_benzyl_ester	12,36	Bcl-2	59,64	scutellarin benzyl ester	Bcl-2	null	24224(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of scutellarin_benzyl_ester on the expressions of Bcl-2 and Bax in cardiomyocytes injured by acute hypoxia -RSB- .
17907134	0	scyphostatin	38,50	neutral_sphingomyelinase	74,98	scyphostatin	neutral sphingomyelinase	MESH:C121123	6610	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Concise asymmetric total synthesis of scyphostatin , a potent inhibitor of neutral_sphingomyelinase .
7521171	0	seaprose	122,130	alpha-1-antichymotrypsin	16,40	seaprose	alpha-1-antichymotrypsin	null	12	Chemical	Gene	START_ENTITY|nsubj|Interactions Interactions|nmod|inhibitor inhibitor|amod|END_ENTITY	Interactions of alpha-1-antichymotrypsin , alpha-1-proteinase inhibitor , and alpha-2-macroglobulin with the fungal enzyme , seaprose .
10428373	0	seco-acid	75,84	HMGCoA_reductase	51,67	seco-acid	HMGCoA reductase	null	25675(Tax:10116)	Chemical	Gene	Synthesis|nmod|START_ENTITY Synthesis|nmod|inhibitors inhibitors|nmod|END_ENTITY	Synthesis and biological testings as inhibitors of HMGCoA_reductase of the seco-acid of tuckolide and its C-7 epimer .
16789881	0	seco-amino-cyclopropylindoline	16,46	CC-1065	62,69	seco-amino-cyclopropylindoline	CC-1065	null	940519(Tax:190650)	Chemical	Gene	analog|amod|START_ENTITY analog|nmod|END_ENTITY	A novel achiral seco-amino-cyclopropylindoline -LRB- CI -RRB- analog of CC-1065 and the duocarmycins : design , synthesis and biological studies .
455230	0	secretin	10,18	CEA	62,65	secretin	CEA	MESH:D012633	1084	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of secretin and cholecystokinin-pancreozymin on plasma CEA concentration in patients with pancreatic_carcinoma and pancreatitis .
7172964	0	secretin	54,62	Gastrin	0,7	secretin	Gastrin	MESH:D012633	2520	Chemical	Gene	stimulated|nmod|START_ENTITY cells|acl|stimulated release|nmod|cells release|nsubj|END_ENTITY	Gastrin release from gastrinoma cells stimulated with secretin .
1218824	0	secretin	10,18	gastrin	56,63	secretin	gastrin	MESH:D012633	2520	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|forms forms|nmod|END_ENTITY	Effect of secretin on release of heterogeneous forms of gastrin .
1278648	1	secretin	195,203	gastrin	97,104	secretin	gastrin	MESH:D012633	2520	Chemical	Gene	concentrations|compound|START_ENTITY correlation|nmod|concentrations Effect|nmod|correlation Effect|nmod|food food|nmod|concentrations concentrations|compound|END_ENTITY	Effect of food , acid , and calcitonin on serum gastrin concentrations and component pattern in pernicious_anemia , with correlation to endogenous secretin concentrations in plasma .
3710471	5	secretin	1040,1048	gastrin	970,977	secretin	gastrin	MESH:D012633	2520	Chemical	Gene	challenge|compound|START_ENTITY derived|nmod|challenge derived|nmod|normalization normalization|nmod|levels levels|compound|END_ENTITY	Additional evidence for the primary nature of these EGEP_gastrinomas is derived from the postoperative normalization of high serum gastrin levels and the correction of the abnormal gastrin response to secretin challenge or to calcium infusion tests .
6863881	0	secretin	46,54	gastrin	21,28	secretin	gastrin	MESH:D012633	2520	Chemical	Gene	stimulation|compound|START_ENTITY elevation|nmod|stimulation elevation|compound|END_ENTITY	False-positive serum gastrin elevation during secretin stimulation due to Boots secretin .
7268628	0	secretin	8,16	gastrin	33,40	secretin	gastrin	MESH:D012633	100685087	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	Role of secretin on postprandial gastrin release in the dog : a further study .
1222379	0	secretin	11,19	insulin	23,30	secretin	insulin	MESH:D012633	3630	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of secretin on insulin secretion and glucose tolerance .
17563	0	secretin	10,18	motilin	29,36	secretin	motilin	MESH:D012633	4295	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of secretin on plasma motilin in man .
15918681	0	selectinE	86,95	Lewisx	34,40	selectinE	Lewisx	MESH:D019040	2526	Chemical	Gene	dynamics|nmod|START_ENTITY dynamics|nmod|END_ENTITY	Conformational dynamics of sialyl Lewisx in aqueous solution and its interaction with selectinE .
11860347	0	selegiline	63,73	MAO-B	35,40	selegiline	MAO-B	MESH:D012642	25750(Tax:10116)	Chemical	Gene	potency|nmod|START_ENTITY potency|amod|END_ENTITY	The influence of metabolism on the MAO-B inhibitory potency of selegiline .
14628189	0	selegiline	21,31	MAO-B	78,83	selegiline	MAO-B	MESH:D012642	4129	Chemical	Gene	formulation|nmod|START_ENTITY formulation|dep|bioavailability bioavailability|nmod|inhibition inhibition|amod|END_ENTITY	A new formulation of selegiline : improved bioavailability and selectivity for MAO-B inhibition .
14628190	0	selegiline	30,40	MAO-B	100,105	selegiline	MAO-B	MESH:D012642	4129	Chemical	Gene	formulation|nmod|START_ENTITY formulation|dep|preference preference|nmod|inhibition inhibition|amod|END_ENTITY	A new low-dose formulation of selegiline : clinical efficacy , patient preference and selectivity for MAO-B inhibition .
1658311	0	selegiline	10,20	MAO-B	35,40	selegiline	MAO-B	MESH:D012642	4129	Chemical	Gene	Deprenyl|appos|START_ENTITY Deprenyl|appos|inhibitor inhibitor|amod|END_ENTITY	Deprenyl -LRB- selegiline -RRB- , a selective MAO-B inhibitor with active metabolites ; effects on locomotor activity , dopaminergic neurotransmission and firing rate of nigral dopamine neurons .
2517980	0	selegiline	53,63	MAO-B	12,17	selegiline	MAO-B	MESH:D012642	25750(Tax:10116)	Chemical	Gene	pretreatment|appos|START_ENTITY activity|nmod|pretreatment enzyme|dobj|activity enzyme|nsubj|Recovery Recovery|nmod|END_ENTITY	Recovery of MAO-B enzyme activity after -LRB- - -RRB- deprenyl -LRB- selegiline -RRB- pretreatment , measured in vivo .
7587975	0	selegiline	63,73	MAO-B	47,52	selegiline	MAO-B	MESH:D012642	4129	Chemical	Gene	START_ENTITY|nsubj|Absence Absence|nmod|interactions interactions|nmod|inhibitor inhibitor|amod|END_ENTITY	Absence of acute cocaine interactions with the MAO-B inhibitor selegiline .
7981318	0	selegiline	43,53	MAO-B	27,32	selegiline	MAO-B	MESH:D012642	4129	Chemical	Gene	START_ENTITY|nsubj|assay assay|nmod|inhibitor inhibitor|amod|END_ENTITY	An enzymatic assay for the MAO-B inhibitor selegiline in plasma .
8302308	0	selegiline	75,85	monoamine_oxidase-B	23,42	selegiline	monoamine oxidase-B	MESH:D012642	4129	Chemical	Gene	action|nmod|START_ENTITY END_ENTITY|nmod|action	The relevance of glial monoamine_oxidase-B and polyamines to the action of selegiline in Parkinson 's _ disease .
15339864	0	selegiline	126,136	monoamine_oxidase_B	89,108	selegiline	monoamine oxidase B	MESH:D012642	25750(Tax:10116)	Chemical	Gene	comparison|nmod|START_ENTITY activity|dep|comparison activity|nmod|rasagiline rasagiline|appos|inhibitor inhibitor|nmod|END_ENTITY	Cardiovascular activity of rasagiline , a selective and potent inhibitor of mitochondrial monoamine_oxidase_B : comparison with selegiline .
21858609	0	selegiline	11,21	monoamine_oxidase_B	25,44	selegiline	monoamine oxidase B	MESH:D012642	109731(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effects of selegiline , a monoamine_oxidase_B inhibitor , on differentiation of P19 embryonal_carcinoma stem cells , into neuron-like cells .
16062100	0	selegiline	21,31	monoamine_oxidase_type-B	58,82	selegiline	monoamine oxidase type-B	MESH:D012642	4129	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|inhibitor inhibitor|amod|END_ENTITY	Remarkable effect of selegiline -LRB- L-deprenyl -RRB- , a selective monoamine_oxidase_type-B inhibitor , in a patient with severe refractory_depression : a case report .
9243352	0	selegiline	51,61	monoamine_oxidase_type_B	23,47	selegiline	monoamine oxidase type B	MESH:D012642	4129	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of platelet monoamine_oxidase_type_B by selegiline .
9243353	0	selegiline	37,47	monoamine_oxidase_type_B	81,105	selegiline	monoamine oxidase type B	MESH:D012642	4129	Chemical	Gene	metabolite|nmod|START_ENTITY Desmethylselegiline|appos|metabolite inhibitor|nsubj|Desmethylselegiline inhibitor|nmod|END_ENTITY	Desmethylselegiline , a metabolite of selegiline , is an irreversible inhibitor of monoamine_oxidase_type_B in humans .
7690291	0	selenate	74,82	lipoprotein_lipase	12,30	selenate	lipoprotein lipase	MESH:C055793	24539(Tax:10116)	Chemical	Gene	Increase|nmod|START_ENTITY Increase|nmod|activity activity|amod|END_ENTITY	Increase in lipoprotein_lipase activity in isolated rat adipose tissue by selenate .
7615089	0	selenite	42,50	AP-1	0,4	selenite	AP-1	MESH:D018038	3726	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|activity activity|compound|END_ENTITY	AP-1 DNA-binding activity is inhibited by selenite and selenodiglutathione .
10967555	0	selenite	11,19	estrogen_receptor-alpha	23,46	selenite	estrogen receptor-alpha	MESH:D018038	2099	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|amod|END_ENTITY	Effects of selenite on estrogen_receptor-alpha expression and activity in MCF-7 breast_cancer cells .
7125906	0	selenite	40,48	glutathione_reductase	15,36	selenite	glutathione reductase	MESH:D018038	116686(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY END_ENTITY|nmod|metabolism	Involvement of glutathione_reductase in selenite metabolism and toxicity , studied in isolated rat hepatocytes .
22100759	0	selenite	23,31	lipoamide_dehydrogenase	49,72	selenite	lipoamide dehydrogenase	MESH:D018038	1738	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activity activity|amod|END_ENTITY	Contrasting effects of selenite and tellurite on lipoamide_dehydrogenase activity suggest a different biological behaviour of the two chalcogens .
3622906	0	selenite	55,63	ornithine_decarboxylase	96,119	selenite	ornithine decarboxylase	MESH:D018038	24609(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|amod|END_ENTITY	Selenium and polyamine metabolism : different effect of selenite on liver and bursa of Fabricius ornithine_decarboxylase activity .
17523932	0	selenite	23,31	p53	35,38	selenite	p53	MESH:D018038	7157	Chemical	Gene	Lack|nmod|START_ENTITY Lack|nmod|END_ENTITY	Lack of effect of oral selenite on p53 associated gene expression during TL01 therapy of psoriasis patients .
8546882	0	selenium	32,40	A-II	60,64	selenium	A-II	MESH:D012643	114548	Chemical	Gene	relationship|nmod|START_ENTITY END_ENTITY|nsubj|relationship	Consistent relationship between selenium and apolipoprotein A-II concentrations in the sera of fasting middle-aged male abstainers and regular consumers of alcohol .
17314095	0	selenium	46,54	Apolipoprotein_E_receptor-2	0,27	selenium	Apolipoprotein E receptor-2	MESH:D012643	16975(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY mediates|dobj|uptake mediates|nsubj|END_ENTITY	Apolipoprotein_E_receptor-2 -LRB- ApoER2 -RRB- mediates selenium uptake from selenoprotein P by the mouse testis .
25870994	0	selenium	10,18	CD4	38,41	selenium	CD4	MESH:D012643	920	Chemical	Gene	supplementation|compound|START_ENTITY supplementation|nmod|END_ENTITY	Effect of selenium supplementation on CD4 + T-cell recovery , viral suppression and morbidity of HIV-infected patients in Rwanda : a randomized controlled trial .
19661375	0	selenium	17,25	CEA	81,84	selenium	CEA	MESH:D012643	1084	Chemical	Gene	levels|compound|START_ENTITY levels|nmod|END_ENTITY	Serum and tissue selenium levels in gastric_cancer patients and correlation with CEA .
19917098	0	selenium	41,49	CatSper	17,24	selenium	CatSper	MESH:D012643	225865(Tax:10090)	Chemical	Gene	family|nmod|START_ENTITY family|compound|END_ENTITY	Up-regulation of CatSper genes family by selenium .
22288306	0	selenium	38,46	GLUT4	68,73	selenium	GLUT4	MESH:D012643	25139(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effect of insulin in combination with selenium on Irs/PI3K-mediated GLUT4 expression in cardiac muscle of diabetic rats .
12496980	0	selenium	48,56	GPX1	67,71	selenium	GPX1	MESH:D012643	2876	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Association between the GCG polymorphism of the selenium dependent GPX1 gene and the risk of young onset prostate_cancer .
23289525	0	selenium	53,61	GPX1	14,18	selenium	GPX1	MESH:D012643	2876	Chemical	Gene	association|nmod|START_ENTITY END_ENTITY|nmod|association	The impact of GPX1 on the association of groundwater selenium and depression : a Project FRONTIER study .
26658762	0	selenium	44,52	GPX1	142,146	selenium	GPX1	MESH:D012643	853842(Tax:4932)	Chemical	Gene	yeast|compound|START_ENTITY damage|nmod|yeast damage|dep|trial trial|nmod|respect respect|nmod|polymorphism polymorphism|compound|END_ENTITY	DNA damage and oxidative stress response to selenium yeast in the non-smoking individuals : a short-term supplementation trial with respect to GPX1 and SEPP1 polymorphism .
21372135	0	selenium	23,31	GPx1	79,83	selenium	GPx1	MESH:D012643	101710466	Chemical	Gene	utilization|nmod|START_ENTITY utilization|amod|due due|nmod|defect defect|nmod|expression expression|amod|END_ENTITY	Reduced utilization of selenium by naked_mole_rats due to a specific defect in GPx1 expression .
25894865	0	selenium	61,69	GPx1	145,149	selenium	GPx1	MESH:D012643	2876	Chemical	Gene	impact|nmod|START_ENTITY study|nmod|impact supplementation|nsubj|study supplementation|nmod|genotypes genotypes|amod|END_ENTITY	A randomized-controlled , double-blind study of the impact of selenium supplementation on thyroid autoimmunity and inflammation with focus on the GPx1 genotypes .
7782896	0	selenium	125,133	Glutathione_peroxidase	0,22	selenium	Glutathione peroxidase	MESH:D012643	24404(Tax:10116)	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|hydroperoxide_glutathione_peroxidase hydroperoxide_glutathione_peroxidase|amod|END_ENTITY	Glutathione_peroxidase and phospholipid hydroperoxide_glutathione_peroxidase are differentially regulated in rats by dietary selenium .
26595309	0	selenium	12,20	IGF-IR	63,69	selenium	IGF-IR	MESH:D012643	16001(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|appos|END_ENTITY	The role of selenium in insulin-like_growth_factor_I_receptor -LRB- IGF-IR -RRB- expression and regulation of apoptosis in mouse osteoblasts .
8005524	0	selenium	29,37	PHGPX	105,110	selenium	PHGPX	MESH:D012643	29328(Tax:10116)	Chemical	Gene	supplementation|compound|START_ENTITY effect|nmod|supplementation END_ENTITY|nsubj|effect	Protective effect of dietary selenium supplementation on delayed cardiotoxicity of adriamycin in rat : is PHGPX but not GPX involved ?
16500636	0	selenium	59,67	Plasma_glutathione_peroxidase	0,29	selenium	Plasma glutathione peroxidase	MESH:D012643	2878	Chemical	Gene	level|compound|START_ENTITY END_ENTITY|nmod|level	Plasma_glutathione_peroxidase by ELISA and relationship to selenium level .
26734501	0	selenium	4,12	SEPP1	24,29	selenium	SEPP1	MESH:D012643	6414	Chemical	Gene	content|compound|START_ENTITY content|nmod|END_ENTITY	The selenium content of SEPP1 versus selenium requirements in vertebrates .
23084568	0	selenium	32,40	Sel_P	82,87	selenium	Sel P	MESH:D012643	102170076	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of maternal and dietary selenium -LRB- Se-enriched yeast -RRB- on the expression of Sel_P and apoER2 of germ cells of their offspring in goats .
23830627	0	selenium	49,57	Selenoprotein	0,13	selenium	Selenoprotein	MESH:D012643	93684(Tax:10090)	Chemical	Gene	efficacy|nmod|START_ENTITY biomarker|nmod|efficacy W|nmod|biomarker W|compound|END_ENTITY	Selenoprotein W as biomarker for the efficacy of selenium compounds to act as source for selenoprotein biosynthesis .
24626785	0	selenium	33,41	Selenoprotein_P	0,15	selenium	Selenoprotein P	MESH:D012643	6414	Chemical	Gene	transporter|compound|START_ENTITY transporter|nsubj|END_ENTITY	Selenoprotein_P is the essential selenium transporter for bones .
25068390	0	selenium	29,37	Selenoprotein_P	0,15	selenium	Selenoprotein P	MESH:D012643	20363(Tax:10090)	Chemical	Gene	protein|compound|START_ENTITY protein|nsubj|END_ENTITY	Selenoprotein_P is the major selenium transport protein in mouse milk .
21170571	0	selenium	96,104	Selenoprotein_W	0,15	selenium	Selenoprotein W	MESH:D012643	100310814(Tax:9031)	Chemical	Gene	affected|nmod|START_ENTITY affected|nsubjpass|expression expression|amod|END_ENTITY	Selenoprotein_W gene expression in the gastrointestinal tract of chicken is affected by dietary selenium .
22234495	0	selenium	46,54	Selenoprotein_W	11,26	selenium	Selenoprotein W	MESH:D012643	100310814(Tax:9031)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Effects of Selenoprotein_W gene expression by selenium involves regulation of mRNA stability in chicken embryos neurons .
16600092	0	selenium	12,20	TERT	38,42	selenium	TERT	MESH:D012643	301965(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of selenium on expression of TERT , c-Myc and p53 induced by cadmium in rat liver -RSB- .
17937623	0	selenium	10,18	Txnrd1	56,62	selenium	Txnrd1	MESH:D012643	50493(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	Effect of selenium on thioredoxin reductase activity in Txnrd1 or Txnrd2 hemizygous mice .
16410637	0	selenium	8,16	activator_protein_1	66,85	selenium	activator protein 1	MESH:D012643	16476(Tax:10090)	Chemical	Gene	Role|nmod|START_ENTITY Role|dep|involvement involvement|nmod|END_ENTITY	Role of selenium in regulation of spermatogenesis : involvement of activator_protein_1 .
23478569	0	selenium	32,40	alpha-1_antitrypsin	44,63	selenium	alpha-1 antitrypsin	MESH:D012643	5265	Chemical	Gene	START_ENTITY|nmod|deficiency deficiency|amod|END_ENTITY	Is there a therapeutic role for selenium in alpha-1_antitrypsin deficiency ?
19294445	0	selenium	50,58	apolipoprotein_A-I	28,46	selenium	apolipoprotein A-I	MESH:D012643	335	Chemical	Gene	status|compound|START_ENTITY Regulation|nmod|status Regulation|nmod|END_ENTITY	Regulation of expression of apolipoprotein_A-I by selenium status in human liver hepatoblastoma cells .
12666833	0	selenium	11,19	c-fos	34,39	selenium	c-fos	MESH:D012643	314322(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|mRNA mRNA|amod|END_ENTITY	Effects of selenium and iodine on c-fos and c-jun mRNA and their protein expressions in cultured rat hippocampus cells .
16004321	0	selenium	25,33	c-fos	55,60	selenium	c-fos	MESH:D012643	314322(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Antagonistic effects of selenium on the expression of c-fos in central nerval system of rat included by mercury contaminated rice -RSB- .
11978490	0	selenium	113,121	cyclooxygenase-2	50,66	selenium	cyclooxygenase-2	MESH:D012643	5743	Chemical	Gene	deficiency|compound|START_ENTITY macrophages|nmod|deficiency macrophages|amod|END_ENTITY	Nuclear factor-kappaB mediates over-expression of cyclooxygenase-2 during activation of RAW 264.7 macrophages in selenium deficiency .
11846010	0	selenium	56,64	erythropoietin	32,46	selenium	erythropoietin	MESH:D012643	2056	Chemical	Gene	levels|compound|START_ENTITY effect|nmod|levels effect|nmod|END_ENTITY	The effect of recombinant human erythropoietin on serum selenium levels in hemodialysis patients .
22983684	0	selenium	11,19	glucagon-like_peptide-1_receptor	37,69	selenium	glucagon-like peptide-1 receptor	MESH:D012643	25051(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|acl|END_ENTITY	Effects of selenium and exendin-4 on glucagon-like_peptide-1_receptor , IRS-1 , and Raf-1 in the liver of diabetic rats .
12577306	1	selenium	113,121	glucose	133,140	selenium	insulin	MESH:D012643	3630	Chemical	Gene	transport|compound|START_ENTITY transport|compound|END_ENTITY	In insulin-sensitive 3T3-L1 adipocytes , selenium stimulates glucose transport and antilipolysis and these actions of selenium , like insulin actions , are sensitive to wortmanin , an inhibitor of phosphatidylinositol-3-kinase -LRB- PI3K -RRB- .
1690709	0	selenium	88,96	glutathione_S-transferase	36,61	selenium	glutathione S-transferase	MESH:D012643	58962(Tax:10116)	Chemical	Gene	nutrition|compound|START_ENTITY induction|nmod|nutrition induction|nmod|subunits subunits|amod|END_ENTITY	The induction of specific rat liver glutathione_S-transferase subunits under inadequate selenium nutrition causes an increase in prostaglandin_F2_alpha formation .
3435464	0	selenium	15,23	glutathione_S-transferase	51,76	selenium	glutathione S-transferase	MESH:D012643	58962(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|peroxidase peroxidase|amod|END_ENTITY	The effects of selenium and copper_deficiencies on glutathione_S-transferase and glutathione peroxidase in rat liver .
6466377	0	selenium	70,78	glutathione_S-transferase	24,49	selenium	glutathione S-transferase	MESH:D012643	58962(Tax:10116)	Chemical	Gene	changes|nmod|START_ENTITY changes|nmod|activity activity|amod|END_ENTITY	Differential changes of glutathione_S-transferase activity by dietary selenium .
7518676	0	selenium	80,88	glutathione_S-transferase	14,39	selenium	glutathione S-transferase	MESH:D012643	58962(Tax:10116)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of glutathione_S-transferase gene expression and activity by dietary selenium .
26273132	0	selenium	8,16	glutathione_peroxidase	31,53	selenium	glutathione peroxidase	MESH:D012643	24404(Tax:10116)	Chemical	Gene	regulation|compound|START_ENTITY regulation|nmod|mRNA mRNA|amod|END_ENTITY	Dietary selenium regulation of glutathione_peroxidase mRNA and other selenium-dependent parameters in male rats .
2742329	0	selenium	31,39	glutathione_peroxidase	43,65	selenium	glutathione peroxidase	MESH:D012643	542974(Tax:4565)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effects of durum wheat dietary selenium on glutathione_peroxidase activity and Se content in long-term-fed rats .
3676160	0	selenium	16,24	glutathione_peroxidase	39,61	selenium	glutathione peroxidase	MESH:D012643	100135925(Tax:8022)	Chemical	Gene	deficiency|compound|START_ENTITY effects|nmod|deficiency effects|nmod|activity activity|amod|END_ENTITY	Some effects of selenium deficiency on glutathione_peroxidase -LRB- EC 1.11.1.9 -RRB- activity and tissue pathology in rainbow_trout -LRB- Salmo_gairdneri -RRB- .
6846235	0	selenium	19,27	glutathione_peroxidase	67,89	selenium	glutathione peroxidase	MESH:D012643	542974(Tax:4565)	Chemical	Gene	Bioavailability|nmod|START_ENTITY assessed|nsubj|Bioavailability assessed|nmod|activity activity|amod|END_ENTITY	Bioavailability of selenium to Finnish men as assessed by platelet glutathione_peroxidase activity and other blood parameters .
7189775	0	selenium	121,129	glutathione_peroxidase	162,184	selenium	glutathione peroxidase	MESH:D012643	100306295(Tax:3847)	Chemical	Gene	Availability|nmod|START_ENTITY Availability|acl|restoring restoring|dobj|activity activity|amod|END_ENTITY	Availability of selenium in fish meal in comparison with soybean meal , corn gluten meal and selenomethionine relative to selenium in sodiumselenite for restoring glutathione_peroxidase activity in selenium-depleted chicks .
7189775	0	selenium	16,24	glutathione_peroxidase	162,184	selenium	glutathione peroxidase	MESH:D012643	100306295(Tax:3847)	Chemical	Gene	Availability|nmod|START_ENTITY Availability|acl|restoring restoring|dobj|activity activity|amod|END_ENTITY	Availability of selenium in fish meal in comparison with soybean meal , corn gluten meal and selenomethionine relative to selenium in sodiumselenite for restoring glutathione_peroxidase activity in selenium-depleted chicks .
15963764	0	selenium	21,29	hsp70	33,38	selenium	hsp70	MESH:D012643	423504(Tax:9031)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|response response|amod|END_ENTITY	Influence of organic selenium on hsp70 response of heat-stressed and enteropathogenic Escherichia_coli-challenged broiler chickens -LRB- Gallus_gallus -RRB- .
26595309	0	selenium	12,20	insulin-like_growth_factor_I_receptor	24,61	selenium	insulin-like growth factor I receptor	MESH:D012643	16001(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	The role of selenium in insulin-like_growth_factor_I_receptor -LRB- IGF-IR -RRB- expression and regulation of apoptosis in mouse osteoblasts .
11049201	0	selenium	109,117	phospholipid_hydroperoxide_glutathione_peroxidase	16,65	selenium	phospholipid hydroperoxide glutathione peroxidase	MESH:D012643	29328(Tax:10116)	Chemical	Gene	deficiency|compound|START_ENTITY spermatozoon|nmod|deficiency mRNA|nmod|spermatozoon mRNA|amod|END_ENTITY	Analysis of the phospholipid_hydroperoxide_glutathione_peroxidase mRNA in the rat spermatozoon and effect of selenium deficiency on the mRNA .
9285063	0	selenium	10,18	phospholipid_hydroperoxide_glutathione_peroxidase	28,77	selenium	phospholipid hydroperoxide glutathione peroxidase	MESH:D012643	2879	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effect of selenium on human phospholipid_hydroperoxide_glutathione_peroxidase expression and host cell susceptibility to lipid hydroperoxide-mediated injury .
22291978	0	selenium	91,99	selenocysteine_lyase	121,141	selenium	selenocysteine lyase	MESH:D012643	51540	Chemical	Gene	specificity|compound|START_ENTITY specificity|nmod|END_ENTITY	Biochemical discrimination between selenium and sulfur 2 : mechanistic investigation of the selenium specificity of human selenocysteine_lyase .
12521380	0	selenium	53,61	selenoprotein	34,47	selenium	selenoprotein	MESH:D012643	93684(Tax:10090)	Chemical	Gene	delivery|compound|START_ENTITY P|nmod|delivery P|compound|END_ENTITY	Gene disruption discloses role of selenoprotein P in selenium delivery to target tissues .
23830627	0	selenium	49,57	selenoprotein	89,102	selenium	selenoprotein	MESH:D012643	93684(Tax:10090)	Chemical	Gene	efficacy|nmod|START_ENTITY biomarker|nmod|efficacy W|nmod|biomarker compounds|nsubj|W compounds|xcomp|act act|nmod|source source|nmod|biosynthesis biosynthesis|compound|END_ENTITY	Selenoprotein W as biomarker for the efficacy of selenium compounds to act as source for selenoprotein biosynthesis .
10746307	0	selenium	17,25	selenoprotein_P	31,46	selenium	selenoprotein P	MESH:D012643	25651(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|peroxidase peroxidase|compound|END_ENTITY	Incorporation of selenium into selenoprotein_P and extracellular glutathione peroxidase : HPLC-ICPMS data with enriched selenite .
17311913	0	selenium	92,100	selenoprotein_P	45,60	selenium	selenoprotein P	MESH:D012643	20363(Tax:10090)	Chemical	Gene	supply|nmod|START_ENTITY necessary|nmod|supply necessary|nsubj|domain domain|nmod|END_ENTITY	The selenium-rich C-terminal domain of mouse selenoprotein_P is necessary for the supply of selenium to brain and testis but not for the maintenance of whole body selenium .
17311961	0	selenium	79,87	selenoprotein_P	44,59	selenium	selenoprotein P	MESH:D012643	20363(Tax:10090)	Chemical	Gene	maintenance|nmod|START_ENTITY END_ENTITY|nmod|maintenance	All regions of mouse brain are dependent on selenoprotein_P for maintenance of selenium .
17536041	0	selenium	107,115	selenoprotein_P	35,50	selenium	selenoprotein P	MESH:D012643	6414	Chemical	Gene	determine|xcomp|START_ENTITY determine|nsubj|polymorphisms polymorphisms|nmod|gene gene|compound|END_ENTITY	Genetic polymorphisms in the human selenoprotein_P gene determine the response of selenoprotein markers to selenium supplementation in a gender-specific manner -LRB- the SELGEN study -RRB- .
17553827	0	selenium	94,102	selenoprotein_P	74,89	selenium	selenoprotein P	MESH:D012643	20344(Tax:10090)	Chemical	Gene	supply|compound|START_ENTITY END_ENTITY|nmod|supply	The selenoproteome exhibits widely varying , tissue-specific dependence on selenoprotein_P for selenium supply .
20573787	0	selenium	49,57	selenoprotein_P	16,31	selenium	selenoprotein P	MESH:D012643	6414	Chemical	Gene	biomarkers|compound|START_ENTITY biomarkers|compound|END_ENTITY	Optimization of selenoprotein_P and other plasma selenium biomarkers for the assessment of the selenium nutritional requirement : a placebo-controlled , double-blind study of selenomethionine supplementation in selenium-deficient Chinese subjects .
20573787	0	selenium	95,103	selenoprotein_P	16,31	selenium	selenoprotein P	MESH:D012643	6414	Chemical	Gene	requirement|compound|START_ENTITY assessment|nmod|requirement Optimization|nmod|assessment Optimization|nmod|biomarkers biomarkers|compound|END_ENTITY	Optimization of selenoprotein_P and other plasma selenium biomarkers for the assessment of the selenium nutritional requirement : a placebo-controlled , double-blind study of selenomethionine supplementation in selenium-deficient Chinese subjects .
22761431	0	selenium	79,87	selenoprotein_P	19,34	selenium	selenoprotein P	MESH:D012643	20363(Tax:10090)	Chemical	Gene	rat|nmod|START_ENTITY supplies|xcomp|rat supplies|nsubj|END_ENTITY	Long isoform mouse selenoprotein_P -LRB- Sepp1 -RRB- supplies rat myoblast L8 cells with selenium via endocytosis mediated by heparin binding properties and apolipoprotein E receptor-2 -LRB- ApoER2 -RRB- .
23038251	0	selenium	67,75	selenoprotein_P	14,29	selenium	selenoprotein P	MESH:D012643	20363(Tax:10090)	Chemical	Gene	central|xcomp|START_ENTITY central|nsubj|Production Production|nmod|END_ENTITY	Production of selenoprotein_P -LRB- Sepp1 -RRB- by hepatocytes is central to selenium homeostasis .
21331563	0	selenium	8,16	selenoprotein_W	25,40	selenium	selenoprotein W	MESH:D012643	100310814(Tax:9031)	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|expression expression|compound|END_ENTITY	Dietary selenium affects selenoprotein_W gene expression in the liver of chicken .
21519859	0	selenium	19,27	selenoprotein_W	31,46	selenium	selenoprotein W	MESH:D012643	100310814(Tax:9031)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of dietary selenium on selenoprotein_W gene expression in the chicken immune organs .
21708100	0	selenium	8,16	selenoprotein_W	56,71	selenium	selenoprotein W	MESH:D012643	100310814(Tax:9031)	Chemical	Gene	influences|nsubj|START_ENTITY influences|dobj|levels levels|nmod|END_ENTITY	Dietary selenium influences pancreatic tissue levels of selenoprotein_W in chickens .
2293564	0	selenium	35,43	tank	25,29	selenium	tank	MESH:D012643	539513(Tax:9913)	Chemical	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	An investigation of bulk tank milk selenium levels in the San Joaquin Valley of California .
9890567	0	selenium	10,18	thioredoxin_reductase	26,47	selenium	thioredoxin reductase	MESH:D012643	113898(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Effect of selenium on rat thioredoxin_reductase activity : increase by supranutritional selenium and decrease by selenium deficiency .
22086213	0	selenium	62,70	thymic_stromal_lymphopoietin	19,47	selenium	thymic stromal lymphopoietin	MESH:D012643	85480	Chemical	Gene	suppression|nmod|START_ENTITY suppression|nmod|expression expression|compound|END_ENTITY	The suppression of thymic_stromal_lymphopoietin expression by selenium .
14559319	0	selenium	59,67	tumor_necrosis_factor-alpha	8,35	selenium	tumor necrosis factor-alpha	MESH:D012643	7124	Chemical	Gene	supplementation|compound|START_ENTITY END_ENTITY|nmod|supplementation	Soluble tumor_necrosis_factor-alpha receptor type 1 during selenium supplementation in psoriasis patients .
1395717	0	selenocysteine	29,43	TRSP	55,59	selenocysteine	TRSP	MESH:D017279	7234	Chemical	Gene	gene|amod|START_ENTITY localization|nmod|gene localization|appos|END_ENTITY	Regional localization of the selenocysteine tRNA gene -LRB- TRSP -RRB- on human chromosome 19 .
12588969	0	selenocysteine	25,39	Trsp	60,64	selenocysteine	Trsp	MESH:D017279	7234	Chemical	Gene	gene|amod|START_ENTITY removal|nmod|gene removal|appos|END_ENTITY	Selective removal of the selenocysteine tRNA -LSB- Ser -RSB- Sec gene -LRB- Trsp -RRB- in mouse mammary epithelium .
14660662	0	selenocysteine	25,39	Trsp	54,58	selenocysteine	Trsp	MESH:D017279	22069(Tax:10090)	Chemical	Gene	tRNA|amod|START_ENTITY gene|amod|tRNA gene|appos|END_ENTITY	Specific excision of the selenocysteine tRNA -LSB- Ser -RSB- Sec -LRB- Trsp -RRB- gene in mouse liver demonstrates an essential role of selenoproteins in liver function .
7565585	0	selenocysteine	54,68	Trsp	90,94	selenocysteine	Trsp	MESH:D017279	22069(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|gene gene|appos|END_ENTITY	Cloning , structural analysis and mapping of the mouse selenocysteine tRNA -LRB- -LSB- Ser -RSB- Sec -RRB- gene -LRB- Trsp -RRB- .
9159106	0	selenocysteine	69,83	Trsp	95,99	selenocysteine	Trsp	MESH:D017279	22069(Tax:10090)	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Early embryonic_lethality caused by targeted disruption of the mouse selenocysteine tRNA gene -LRB- Trsp -RRB- .
23914919	0	selenocysteine	16,30	selenoprotein_S	61,76	selenocysteine	selenoprotein S	MESH:D017279	55829	Chemical	Gene	Contribution|nmod|START_ENTITY Contribution|nmod|END_ENTITY	Contribution of selenocysteine to the peroxidase activity of selenoprotein_S .
1395717	0	selenocysteine	29,43	tRNA	44,48	selenocysteine	tRNA	MESH:D017279	4563	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Regional localization of the selenocysteine tRNA gene -LRB- TRSP -RRB- on human chromosome 19 .
18039655	0	selenocysteine	16,30	tRNA	31,35	selenocysteine	tRNA	MESH:D017279	17733(Tax:10090)	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Deletion of the selenocysteine tRNA gene in macrophages and liver results in compensatory gene induction of cytoprotective enzymes by Nrf2 .
24763048	0	selenocystine	63,76	TrxR1	101,106	selenocystine	TrxR1	MESH:C009226	7296	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Enhancement of auranofin-induced lung_cancer cell apoptosis by selenocystine , a natural inhibitor of TrxR1 in vitro and in vivo .
8033315	0	selenodiglutathione	24,43	p53	52,55	selenodiglutathione	p53	MESH:C017710	7157	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	The selenium metabolite selenodiglutathione induces p53 and apoptosis : relevance to the chemopreventive effects of selenium ?
19459742	0	selenomethionine	22,38	p53	90,93	selenomethionine	p53	MESH:D012645	7157	Chemical	Gene	START_ENTITY|acl|ionizing ionizing|nmod|modulation modulation|nmod|suppressor suppressor|compound|END_ENTITY	Protective effects of selenomethionine against ionizing radiation under the modulation of p53 tumor suppressor .
21653573	0	selenomethionine	8,24	p53	72,75	selenomethionine	p53	MESH:D012645	301300(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|methylation methylation|nmod|gene gene|compound|END_ENTITY	Dietary selenomethionine increases exon-specific DNA methylation of the p53 gene in rat liver and colon mucosa .
24023291	0	selenomethionine	96,112	p53	41,44	selenomethionine	p53	MESH:D012645	7157	Chemical	Gene	stabilization|acl|START_ENTITY stabilization|compound|END_ENTITY	Enhanced redox_factor_1 -LRB- REF1 -RRB- - modulated p53 stabilization and JNK1 dissociation in response to selenomethionine .
20674356	0	selenophene	13,24	CHK1	46,50	selenophene	CHK1	CHEBI:30857	1111	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Synthesis of selenophene derivatives as novel CHK1 inhibitors .
18156471	0	selenophosphate	27,42	SPS1	54,58	selenophosphate	SPS1	MESH:C076818	692787(Tax:7091)	Chemical	Gene	functions|amod|START_ENTITY functions|compound|END_ENTITY	Selenoproteinless animals : selenophosphate synthetase SPS1 functions in a pathway unrelated to selenocysteine biosynthesis .
17703234	0	seliciclib	47,57	Mcl-1	71,76	seliciclib	Mcl-1	MESH:C104586	4170	Chemical	Gene	acts|amod|START_ENTITY acts|nmod|END_ENTITY	Crosstalk among Bcl-2 family members in B-CLL : seliciclib acts via the Mcl-1 / Noxa axis and gradual exhaustion of Bcl-2 protection .
22233925	0	seliciclib	161,171	p57	38,41	seliciclib	p57	MESH:C104586	1028	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	The cyclin-dependent kinase inhibitor p57 -LRB- Kip2 -RRB- is epigenetically regulated in carboplatin resistance and results in collateral sensitivity to the CDK inhibitor seliciclib in ovarian_cancer .
24567366	0	selumetinib	79,90	BRAF	104,108	selumetinib	BRAF	MESH:C517975	673	Chemical	Gene	START_ENTITY|nmod|melanoma melanoma|compound|END_ENTITY	DOC-MEK : a double-blind randomized phase II trial of docetaxel with or without selumetinib in wild-type BRAF advanced melanoma .
25322874	0	selumetinib	18,29	K-RAS	109,114	selumetinib	K-RAS	MESH:C517975	3845	Chemical	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	Phase II study of selumetinib -LRB- AZD6244 , ARRY-142886 -RRB- plus irinotecan as second-line therapy in patients with K-RAS mutated colorectal_cancer .
21910575	0	selumetinib	21,32	MEK1/2	13,19	selumetinib	MEK1/2	MESH:C517975	5604;5605	Chemical	Gene	Inhibitor|appos|START_ENTITY Inhibitor|nmod|END_ENTITY	Inhibitor of MEK1/2 , selumetinib , for biliary_tract_cancer .
22343622	0	selumetinib	22,33	MEK1/2	4,10	selumetinib	MEK1/2	MESH:C517975	5604;5605	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	The MEK1/2 inhibitor , selumetinib -LRB- AZD6244 ; ARRY-142886 -RRB- , enhances anti-tumour efficacy when combined with conventional chemotherapeutic agents in human tumour xenograft models .
22569000	0	selumetinib	24,35	MEK1/2	62,68	selumetinib	MEK1/2	MESH:C517975	5604;5605	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Intrinsic resistance to selumetinib , a selective inhibitor of MEK1/2 , by cAMP-dependent protein kinase A activation in human lung and colorectal_cancer cells .
26666244	0	selumetinib	19,30	MEK1/2	56,62	selumetinib	MEK1/2	MESH:C517975	5604;5605	Chemical	Gene	study|nmod|START_ENTITY study|appos|inhibitor inhibitor|compound|END_ENTITY	A phase I study of selumetinib -LRB- AZD6244/ARRY -142866 -RRB- , a MEK1/2 inhibitor , in combination with cetuximab in refractory solid tumors and KRAS mutant colorectal_cancer .
11683995	0	semaphorin	19,29	Plexin-A3	0,9	semaphorin	Plexin-A3	MESH:D039961	55558	Chemical	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	Plexin-A3 mediates semaphorin signaling and regulates the development of hippocampal axonal projections .
9427525	0	semaphorin	39,49	semaphorin_Z	64,76	semaphorin	semaphorin Z	MESH:D039961	84609(Tax:10116)	Chemical	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Molecular cloning of a novel member of semaphorin family genes , semaphorin_Z .
17300923	0	semialdehyde	33,45	Aldh5a1	61,68	semialdehyde	Aldh5a1	CHEBI:26643	214579(Tax:10090)	Chemical	Gene	dehydrogenase|compound|START_ENTITY dehydrogenase|dep|END_ENTITY	Lipid_abnormalities in succinate semialdehyde dehydrogenase -LRB- Aldh5a1 - / - -RRB- deficient mouse brain provide additional evidence for myelin alterations .
3904835	0	sepiapterin	31,42	Carbonyl_reductase	0,18	sepiapterin	Carbonyl reductase	MESH:C016727	266686(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Carbonyl_reductase activity of sepiapterin reductase from rat erythrocytes .
24961103	0	sequoyitol	11,21	NOX4	39,43	sequoyitol	NOX4	MESH:C572459	85431(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of sequoyitol on expression of NOX4 and eNOS in aortas of type 2 diabetic rats -RSB- .
25016868	0	sequoyitol	11,21	NOX4	39,43	sequoyitol	NOX4	MESH:C572459	50507	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of sequoyitol on expression of NOX4 and eNOS induced with glucose in human umbilical vein endothelial cells -RSB- .
24584737	0	serelaxin	31,40	relaxin-2	60,69	serelaxin	relaxin-2	null	6019	Chemical	Gene	injection|nmod|START_ENTITY injection|appos|END_ENTITY	Acute intravenous injection of serelaxin -LRB- recombinant human relaxin-2 -RRB- causes rapid and sustained bradykinin-mediated vasorelaxation .
25101847	0	sericin	42,49	TNF-a	0,5	sericin	TNF-a	null	7124	Chemical	Gene	effect|nmod|START_ENTITY effect|amod|END_ENTITY	TNF-a blocker effect of naringenin-loaded sericin microparticles that are potentially useful in the treatment of psoriasis .
26379831	0	sericin	11,18	growth_hormone	37,51	sericin	growth hormone	null	81668(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of sericin on the testicular growth_hormone / insulin-like_growth_factor-1 axis in a rat model of type 2 diabetes .
21560355	0	sericine	12,20	TGF-beta1	24,33	sericine	TGF-beta1	null	59086(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of sericine on TGF-beta1 / Smad3 signal pathway of diabetic mephropathy rats kidney -RSB- .
7533107	0	serine	22,28	APRF	69,73	serine	APRF	CHEBI:17822	6774	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Interleukin-6-induced serine phosphorylation of transcription factor APRF : evidence for a role in interleukin-6 target gene induction .
11085518	0	serine	119,125	Akt	134,137	serine	Akt	CHEBI:17822	207	Chemical	Gene	START_ENTITY|nmod|cascade cascade|compound|END_ENTITY	Inhibition of BAD phosphorylation either at serine 112 via extracellular_signal-regulated_protein_kinase cascade or at serine 136 via Akt cascade sensitizes human ovarian_cancer cells to cisplatin .
14585966	0	serine	23,29	Akt	0,3	serine	Akt	CHEBI:17822	207	Chemical	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Akt phosphorylation of serine 21 on Pak1 modulates Nck binding and cell migration .
15309026	0	serine	49,55	Akt	42,45	serine	Akt	CHEBI:17822	11651(Tax:10090)	Chemical	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	beta1-Integrins induce phosphorylation of Akt on serine 473 independently of focal adhesion kinase and Src family kinases .
26592809	0	serine	32,38	Akt	28,31	serine	Akt	CHEBI:17822	24185(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Periapical_lesions decrease Akt serine phosphorylation and plasma membrane GLUT4 content in rat skeletal muscle .
16954147	0	serine	98,104	Akt/PKB	90,97	serine	Akt/PKB	CHEBI:17822	11651(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|compound|END_ENTITY	Neuronal polarity is regulated by glycogen synthase kinase-3 -LRB- GSK-3beta -RRB- independently of Akt/PKB serine phosphorylation .
10377265	0	serine	26,32	Angiotensin_II	0,14	serine	Angiotensin II	CHEBI:17822	24179(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates serine phosphorylation of the adaptor protein Nck : physical association with the serine/threonine kinases Pak1 and casein kinase I. Nck is a small adaptor protein consisting exclusively of three SH3 domains and one SH2 domain .
19454314	0	serine	50,56	BCAR3	7,12	serine	BCAR3	CHEBI:17822	8412	Chemical	Gene	regulates|ccomp|START_ENTITY regulates|nsubj|END_ENTITY	AND-34 / BCAR3 regulates adhesion-dependent p130Cas serine phosphorylation and breast_cancer cell growth pattern .
11983683	0	serine	50,56	Bad	80,83	serine	Bad	CHEBI:17822	572	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Activation of JNK1 , RSK2 , and MSK1 is involved in serine 112 phosphorylation of Bad by ultraviolet B radiation .
8622703	0	serine	18,24	Bcr	14,17	serine	Bcr	CHEBI:17822	613	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of Bcr serine kinase by tyrosine phosphorylation .
19234596	0	serine	45,51	Bicaudal-D	34,44	serine	Bicaudal-D	CHEBI:17822	35051(Tax:7227)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Systematic functional analysis of Bicaudal-D serine phosphorylation and intragenic suppression of a female sterile allele of BicD .
23086925	0	serine	68,74	Bromodomain-containing_protein_4	0,32	serine	Bromodomain-containing protein 4	CHEBI:17822	23476	Chemical	Gene	regulates|ccomp|START_ENTITY regulates|nsubj|END_ENTITY	Bromodomain-containing_protein_4 -LRB- BRD4 -RRB- regulates RNA polymerase II serine 2 phosphorylation in human CD4 + T cells .
22855709	0	serine	73,79	C1s	99,102	serine	C1s	CHEBI:17822	716	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Identification of a catalytic exosite for complement component C4 on the serine protease domain of C1s .
15006641	0	serine	9,15	CBP	28,31	serine	CBP	CHEBI:17822	1387	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	Distinct serine residues in CBP and p300 are necessary for their activation by phenylephrine .
1850360	0	serine	25,31	CD45	51,55	serine	CD45	CHEBI:17822	19264(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Interleukin_2 stimulates serine phosphorylation of CD45 in CTLL-2 .4 cells .
10094408	0	serine	105,111	CK2	117,120	serine	CK2	CHEBI:17822	81650(Tax:10116)	Chemical	Gene	site|amod|START_ENTITY site|appos|END_ENTITY	Protein kinase CK2-dependent regulation of p53 function : evidence that the phosphorylation status of the serine 386 -LRB- CK2 -RRB- site of p53 is constitutive and stable .
12091337	0	serine	73,79	CREB	99,103	serine	CREB	CHEBI:17822	1385	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Prostaglandin-E2 enhances EPO-mediated STAT5 transcriptional activity by serine phosphorylation of CREB .
22848689	0	serine	67,73	CRK-II	60,66	serine	CRK-II	CHEBI:17822	1398	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	PAK1 kinase promotes cell motility and invasiveness through CRK-II serine phosphorylation in non-small_cell_lung_cancer cells .
15580268	0	serine	29,35	Chronophin	0,10	serine	Chronophin	CHEBI:17822	57026	Chemical	Gene	phosphatase|compound|START_ENTITY END_ENTITY|appos|phosphatase	Chronophin , a novel HAD-type serine protein phosphatase , regulates cofilin-dependent actin dynamics .
9874688	0	serine	2,8	ClC-3	20,25	serine	ClC-3	CHEBI:17822	1182	Chemical	Gene	residue|amod|START_ENTITY residue|nmod|END_ENTITY	A serine residue in ClC-3 links phosphorylation-dephosphorylation to chloride channel regulation by cell volume .
11447171	0	serine	20,26	ClpP	15,19	serine	ClpP	CHEBI:17822	53895(Tax:10090)	Chemical	Gene	protease|compound|START_ENTITY protease|amod|END_ENTITY	Stress-induced ClpP serine protease of Listeria_monocytogenes is essential for induction of listeriolysin_O-dependent protective immunity .
18198344	7	serine	1419,1425	DAT	1445,1448	serine	DAT	CHEBI:17822	24898(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Consistent with elevated DAT activity in cocaine-experienced animals , a higher level of surface DAT , DAT-PP2Ac association , and decreased serine phosphorylation of DAT were observed in the CPu , but not in the NAcc .
20966071	0	serine	45,51	DNA-dependent_protein_kinase	63,91	serine	DNA-dependent protein kinase	CHEBI:17822	5591	Chemical	Gene	residue|compound|START_ENTITY residue|nmod|END_ENTITY	Phosphorylation of p50 NF-kappaB at a single serine residue by DNA-dependent_protein_kinase is critical for VCAM-1 expression upon TNF treatment .
15128734	0	serine	19,25	Daxx	42,46	serine	Daxx	CHEBI:17822	1616	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Tryptophan 621 and serine 667 residues of Daxx regulate its nuclear export during glucose_deprivation .
23728337	0	serine	69,75	Dock180	95,102	serine	Dock180	CHEBI:17822	1793	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	EGFRvIII stimulates glioma growth and invasion through PKA-dependent serine phosphorylation of Dock180 .
25468898	0	serine	57,63	Dock180	46,53	serine	Dock180	CHEBI:17822	330662(Tax:10090)	Chemical	Gene	residue|compound|START_ENTITY END_ENTITY|nmod|residue	Protein kinase A-dependent phosphorylation of Dock180 at serine residue 1250 is important for glioma growth and invasion stimulated by platelet_derived_growth_factor_receptor a BACKGROUND : Dedicator of cytokinesis 1 -LRB- Dock1 or Dock180 -RRB- , a bipartite guanine_nucleotide exchange factor for Rac1 , plays critical roles in receptor tyrosine kinase-stimulated cancer growth and invasion .
16953577	0	serine	54,60	EF-Tu2	113,119	serine	EF-Tu2	CHEBI:17822	175851(Tax:6239)	Chemical	Gene	specificity|compound|START_ENTITY specificity|nmod|END_ENTITY	Identification of the residues involved in the unique serine specificity of Caenorhabditis_elegans mitochondrial EF-Tu2 .
11342545	0	serine	21,27	Endothelin-1	0,12	serine	Endothelin-1	CHEBI:17822	1906	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Endothelin-1 induces serine phosphorylation of the adaptor protein p66Shc and its association with 14-3-3 protein in glomerular mesangial cells .
23772378	0	serine	85,91	EphA2	115,120	serine	EphA2	CHEBI:17822	1969	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Ephexin4-mediated promotion of cell migration and anoikis resistance is regulated by serine 897 phosphorylation of EphA2 .
25908849	0	serine	12,18	EphA2	42,47	serine	EphA2	CHEBI:17822	487421(Tax:9615)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	HGF-induced serine 897 phosphorylation of EphA2 regulates epithelial morphogenesis of MDCK cells in three-dimensional culture .
26158630	0	serine	52,58	EphA2	78,83	serine	EphA2	CHEBI:17822	1969	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Crucial roles of RSK in cell motility by catalysing serine phosphorylation of EphA2 .
2439087	0	serine	35,41	Epidermal_growth_factor	0,23	serine	Epidermal growth factor	CHEBI:17822	25313(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Epidermal_growth_factor stimulates serine and tyrosine phosphorylation in a 59-kD protein in purified plasma membranes from rat liver .
7925779	0	serine	26,32	Erythropoietin	0,14	serine	Erythropoietin	CHEBI:17822	2056	Chemical	Gene	activity|amod|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	Erythropoietin stimulates serine kinase activity in erythropoietin-dependent cells .
9922457	0	serine	85,91	FAK	111,114	serine	FAK	CHEBI:17822	14083(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Dissociation of FAK/p130 -LRB- CAS -RRB- / c-Src complex during mitosis : role of mitosis-specific serine phosphorylation of FAK .
19861535	0	serine	52,58	FANCD2	37,43	serine	FANCD2	CHEBI:17822	2177	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Fanconi_anemia complementation group FANCD2 protein serine 331 phosphorylation is important for fanconi_anemia pathway function and BRCA2 interaction .
25479686	7	serine	1710,1716	GATA3	1685,1690	serine	GATA3	CHEBI:17822	2625	Chemical	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	This transcriptional regulation is coupled with increased GATA3 protein turnover through progestin-induced GATA3 phosphorylation at serine 308 followed by 26S proteasome-mediated degradation .
9990089	0	serine	4,10	GLT-1	49,54	serine	GLT-1	CHEBI:17822	6506	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Two serine residues of the glutamate transporter GLT-1 are crucial for coupling the fluxes of sodium and the neurotransmitter .
23246341	0	serine	36,42	GSK3b	30,35	serine	GSK3b	CHEBI:17822	84027(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Greater filamin_C , GSK3a , and GSK3b serine phosphorylation in insulin-stimulated isolated skeletal muscles of calorie restricted 24 month-old rats .
16391009	0	serine	28,34	Gata1	19,24	serine	Gata1	CHEBI:17822	14460(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation of Gata1 at serine residues 72 , 142 , and 310 is not essential for hematopoiesis in vivo .
16272153	0	serine	54,60	GluR1	48,53	serine	GluR1	CHEBI:17822	2890	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Extrasynaptic membrane trafficking regulated by GluR1 serine 845 phosphorylation primes AMPA receptors for long-term potentiation .
18455244	0	serine	27,33	GluR1	21,26	serine	GluR1	CHEBI:17822	14799(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	A necessary role for GluR1 serine 831 phosphorylation in appetitive incentive learning .
16126302	0	serine	124,130	GluR6	150,155	serine	GluR6	CHEBI:17822	54257(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Calcium/calmodulin-dependent protein kinase II -LRB- CaMKII -RRB- , through NMDA receptors and L-Voltage-gated channels , modulates the serine phosphorylation of GluR6 during cerebral_ischemia and early reperfusion period in rat hippocampus .
16188906	0	serine	18,24	HSL	14,17	serine	HSL	CHEBI:17822	3991	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of HSL serine phosphorylation in skeletal muscle and adipose tissue .
16690773	0	serine	29,35	HSL	25,28	serine	HSL	CHEBI:17822	3991	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|END_ENTITY	Adrenergic regulation of HSL serine phosphorylation and activity in human skeletal muscle during the onset of exercise .
24603527	0	serine	42,48	HSP70	69,74	serine	HSP70	CHEBI:17822	3308	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	The increase in phosphorylation levels of serine residues of protein HSP70 during holding_time at 17 C is concomitant with a higher cryotolerance of boar_spermatozoa .
21844367	0	serine	40,46	HTRA1	57,62	serine	HTRA1	CHEBI:17822	56213(Tax:10090)	Chemical	Gene	protease|compound|START_ENTITY protease|appos|END_ENTITY	Increased expression of multifunctional serine protease , HTRA1 , in retinal_pigment_epithelium induces polypoidal_choroidal_vasculopathy in mice .
20402766	0	serine	45,51	Hepatocyte_growth_factor_activator	0,34	serine	Hepatocyte growth factor activator	CHEBI:17822	3083	Chemical	Gene	protease|amod|START_ENTITY END_ENTITY|dep|protease	Hepatocyte_growth_factor_activator -LRB- HGFA -RRB- : a serine protease that links tissue injury to activation of hepatocyte_growth_factor .
10049781	0	serine	82,88	Hepatocyte_growth_factor_activator_inhibitor_type_2	0,51	serine	Hepatocyte growth factor activator inhibitor type 2	CHEBI:17822	20733(Tax:10090)	Chemical	Gene	domain|compound|START_ENTITY lacking|dobj|domain END_ENTITY|acl|lacking	Hepatocyte_growth_factor_activator_inhibitor_type_2 lacking the first Kunitz-type serine proteinase inhibitor domain is a predominant product in mouse but not in human .
24657880	0	serine	36,42	Hepsin	52,58	serine	Hepsin	CHEBI:17822	3249	Chemical	Gene	blocks|compound|START_ENTITY blocks|amod|END_ENTITY	Targeted inhibition of cell-surface serine protease Hepsin blocks prostate_cancer bone metastasis .
24701826	0	serine	81,87	Hespintor	107,116	serine	Hespintor	CHEBI:17822	153218	Chemical	Gene	-RSB-|amod|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Prokaryotic expression , purification and activity analysis of recombinant human serine protease inhibitor Hespintor Kazal Domain -RSB- .
9383148	0	serine	19,25	HtrA	4,8	serine	HtrA	CHEBI:17822	56213(Tax:10090)	Chemical	Gene	family|nmod|START_ENTITY family|compound|END_ENTITY	The HtrA family of serine proteases .
12242667	0	serine	10,16	HtrA1	4,9	serine	HtrA1	CHEBI:17822	5654	Chemical	Gene	protease|compound|START_ENTITY protease|amod|END_ENTITY	The HtrA1 serine protease is down-regulated during human melanoma progression and represses growth of metastatic_melanoma cells .
14500695	0	serine	20,26	HtrA1	36,41	serine	HtrA1	CHEBI:17822	5654	Chemical	Gene	Distribution|nmod|START_ENTITY protease|nsubj|Distribution protease|dobj|END_ENTITY	Distribution of the serine protease HtrA1 in normal human tissues .
14973287	0	serine	6,12	HtrA1	0,5	serine	HtrA1	CHEBI:17822	56213(Tax:10090)	Chemical	Gene	protease|compound|START_ENTITY protease|amod|END_ENTITY	HtrA1 serine protease inhibits signaling mediated by Tgfbeta family proteins .
15101818	0	serine	78,84	HtrA1	72,77	serine	HtrA1	CHEBI:17822	5654	Chemical	Gene	protease|compound|START_ENTITY protease|amod|END_ENTITY	Binding of proteins to the PDZ domain regulates proteolytic activity of HtrA1 serine protease .
15855271	0	serine	20,26	HtrA1	36,41	serine	HtrA1	CHEBI:17822	5654	Chemical	Gene	Implications|nmod|START_ENTITY protease|nsubj|Implications protease|dobj|END_ENTITY	Implications of the serine protease HtrA1 in amyloid precursor protein processing .
15993670	0	serine	26,32	HtrA1	20,25	serine	HtrA1	CHEBI:17822	56213(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of mouse HtrA1 serine protease in normal bone and cartilage and its upregulation in joint cartilage damaged by experimental arthritis .
17094466	0	serine	18,24	HtrA1	12,17	serine	HtrA1	CHEBI:17822	5654	Chemical	Gene	START_ENTITY|nsubj|Analysis Analysis|nmod|END_ENTITY	Analysis of HtrA1 serine protease expression in human lung_cancer .
18231652	0	serine	25,31	HtrA1	42,47	serine	HtrA1	CHEBI:17822	101837644	Chemical	Gene	expression|nmod|START_ENTITY Changes|nmod|expression proteases|nsubj|Changes proteases|dobj|END_ENTITY	Changes in expression of serine proteases HtrA1 and HtrA2 during estrogen-induced oxidative stress and nephrocarcinogenesis in male Syrian_hamster .
18667191	0	serine	23,29	HtrA1	39,44	serine	HtrA1	CHEBI:17822	5654	Chemical	Gene	expression|nmod|START_ENTITY protease|nsubj|expression protease|dobj|END_ENTITY	Elevated expression of serine protease HtrA1 in preeclampsia and its role in trophoblast cell migration and invasion .
19301262	0	serine	44,50	HtrA1	60,65	serine	HtrA1	CHEBI:17822	5654	Chemical	Gene	substrates|nmod|START_ENTITY tubulins|nmod|substrates Identification|nmod|tubulins protease|nsubj|Identification protease|dobj|END_ENTITY	Identification of tubulins as substrates of serine protease HtrA1 by mixture-based oriented peptide library screening .
19688690	0	serine	38,44	HtrA1	54,59	serine	HtrA1	CHEBI:17822	5654	Chemical	Gene	alterations|nmod|START_ENTITY protease|nsubj|alterations protease|dobj|END_ENTITY	Expression pattern alterations of the serine protease HtrA1 in normal human placental tissues and in gestational_trophoblastic_diseases .
22923201	0	serine	31,37	HtrA1	47,52	serine	HtrA1	CHEBI:17822	5654	Chemical	Gene	HtrA2|amod|START_ENTITY HtrA2|compound|END_ENTITY	Changes in expression of human serine protease HtrA1 , HtrA2 and HtrA3 genes in benign and malignant thyroid_tumors .
25687108	0	serine	12,18	HtrA1	28,33	serine	HtrA1	CHEBI:17822	5654	Chemical	Gene	Decrease|nmod|START_ENTITY protease|nsubj|Decrease protease|dobj|correlates correlates|amod|END_ENTITY	Decrease in serine protease HtrA1 expression correlates with grade and recurrence in meningiomas .
27058767	0	serine	32,38	HtrA1	48,53	serine	HtrA1	CHEBI:17822	5654	Chemical	Gene	frailty|nmod|START_ENTITY Association|nmod|frailty protease|nsubj|Association protease|dobj|END_ENTITY	Association of frailty with the serine protease HtrA1 in older adults .
16968707	0	serine	68,74	HtrA2	62,67	serine	HtrA2	CHEBI:17822	64704(Tax:10090)	Chemical	Gene	protease|compound|START_ENTITY protease|amod|END_ENTITY	Beta-amyloid_precursor_protein is a direct cleavage target of HtrA2 serine protease .
9036989	0	serine	48,54	IFN-alpha	65,74	serine	IFN-alpha	CHEBI:17822	3439	Chemical	Gene	Activation|nmod|START_ENTITY kinase|nsubj|Activation kinase|nmod|END_ENTITY	Activation of the phosphatidylinositol 3-kinase serine kinase by IFN-alpha .
10810290	0	serine	19,25	IGF-I	10,15	serine	IGF-I	CHEBI:17822	443318(Tax:9940)	Chemical	Gene	metabolism|amod|START_ENTITY Effect|nmod|metabolism Effect|nmod|END_ENTITY	Effect of IGF-I on serine metabolism in fetal sheep .
10521702	0	serine	14,20	IL-13	0,5	serine	IL-13	CHEBI:17822	16163(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	IL-13 induces serine phosphorylation of cPLA2 in mouse peritoneal macrophages leading to arachidonic_acid and PGE2 production and blocks the zymosan-induced serine phosphorylation of cPLA2 and eicosanoid production .
8225567	0	serine	11,17	IL-1_beta	47,56	serine	IL-1 beta	CHEBI:17822	3553	Chemical	Gene	inhibitor|amod|START_ENTITY Effects|nmod|inhibitor Effects|nmod|END_ENTITY	Effects of serine protease inhibitor , TAME , on IL-1_beta in LPS-stimulated human monocytes : relationship between synthesis and release of a 33-kDa precursor and the 17-kDa biologically active species .
11164892	0	serine	13,19	IL-4	0,4	serine	IL-4	CHEBI:17822	16189(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	IL-4 induces serine phosphorylation of the STAT6 transactivation domain in B lymphocytes .
19344727	8	serine	1174,1180	IRS	1200,1203	serine	JNK	CHEBI:17822	26419(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	ALDH2 significantly attenuated alcohol-induced decrease in the insulin-stimulated tyrosine phosphorylation and increase in serine phosphorylation of IRS .
10488146	0	serine	93,99	IRS-1	87,92	serine	IRS-1	CHEBI:17822	3667	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	JAK1-dependent phosphorylation of insulin_receptor_substrate-1 -LRB- IRS-1 -RRB- is inhibited by IRS-1 serine phosphorylation .
11162588	0	serine	15,21	IRS-1	41,46	serine	IRS-1	CHEBI:17822	3667	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Frap-dependent serine phosphorylation of IRS-1 inhibits IRS-1 tyrosine phosphorylation .
15122091	0	serine	44,50	IRS-1	38,43	serine	IRS-1	CHEBI:17822	3667	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Alteration in insulin action : role of IRS-1 serine phosphorylation in the retroregulation of insulin signalling .
15240146	0	serine	17,23	IRS-1	43,48	serine	IRS-1	CHEBI:17822	25467(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Aspirin inhibits serine phosphorylation of IRS-1 in muscle and adipose tissue of septic rats .
16284649	0	serine	50,56	IRS-1	44,49	serine	IRS-1	CHEBI:17822	3667	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents .
17244624	0	serine	76,82	IRS-1	102,107	serine	IRS-1	CHEBI:17822	3667	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Adiponectin sensitizes insulin signaling by reducing p70 S6 kinase-mediated serine phosphorylation of IRS-1 .
17379643	4	serine	660,666	IRS-1	686,691	serine	IRS-1	CHEBI:17822	3667	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	TNFalpha transiently stimulated serine phosphorylation of IRS-1 from 10 min to 1 h , whereas insulin-stimulated IRS-1 tyrosine phosphorylation was inhibited only after TNFalpha treatment longer than 4 h .
18347658	0	serine	97,103	IRS-1	91,96	serine	IRS-1	CHEBI:17822	25467(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	A chronic increase in physical activity inhibits fed-state mTOR/S6K1 signaling and reduces IRS-1 serine phosphorylation in rat skeletal muscle .
18613220	0	serine	85,91	IRS-1	118,123	serine	IRS-1	CHEBI:17822	3667	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Prevention of insulin resistance and beta-cell loss by abrogating PKCepsilon-induced serine phosphorylation of muscle IRS-1 in Psammomys obesus .
21301931	0	serine	101,107	IRS-1	95,100	serine	IRS-1	CHEBI:17822	25467(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Sex steroids influence glucose oxidation through modulation of insulin_receptor expression and IRS-1 serine phosphorylation in target tissues of adult male rat .
21386087	0	serine	138,144	IRS-1	132,137	serine	IRS-1	CHEBI:17822	16367(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|compound|END_ENTITY	p38_mitogen-activated_protein_kinase-dependent transactivation of ErbB receptor family : a novel common mechanism for stress-induced IRS-1 serine phosphorylation and insulin resistance .
23698110	0	serine	32,38	IRS-1	58,63	serine	IRS-1	CHEBI:17822	16367(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Inhibition of the TNF-a-induced serine phosphorylation of IRS-1 at 636/639 by AICAR .
24896641	0	serine	69,75	IRS-1	95,100	serine	IRS-1	CHEBI:17822	25467(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Metformin attenuates palmitate-induced endoplasmic_reticulum_stress , serine phosphorylation of IRS-1 and apoptosis in rat_insulinoma cells .
26604643	0	serine	65,71	IRS-1	59,64	serine	IRS-1	CHEBI:17822	3667	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Hepatitis_C_virus_NS5A promotes insulin resistance through IRS-1 serine phosphorylation and increased gluconeogenesis .
26704265	0	serine	31,37	IRS-1	25,30	serine	IRS-1	CHEBI:17822	3667	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Novel compounds reducing IRS-1 serine phosphorylation for treatment of diabetes .
21098738	0	serine	16,22	IRS-2	42,47	serine	IRS-2	CHEBI:17822	384783(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Insulin-induced serine phosphorylation of IRS-2 via ERK1/2 and mTOR : studies on the function of Ser675 and Ser907 .
14556646	0	serine	112,118	IRS1	138,142	serine	IRS1	CHEBI:17822	3667	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Rosiglitazone , an agonist of peroxisome-proliferator-activated_receptor_gamma -LRB- PPARgamma -RRB- , decreases inhibitory serine phosphorylation of IRS1 in vitro and in vivo .
24391749	0	serine	68,74	IRS1	63,67	serine	IRS1	CHEBI:17822	16367(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Evodiamine inhibits insulin-stimulated mTOR-S6K activation and IRS1 serine phosphorylation in adipocytes and improves glucose tolerance in obese/diabetic mice .
8562658	0	serine	25,31	IT-1	86,90	serine	IT-1	CHEBI:17822	79441	Chemical	Gene	START_ENTITY|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Inhibition of exogenous serine proteinases by a trypsin inhibitor from the buckwheat IT-1 seeds -RSB- .
7642544	0	serine	75,81	I_kappa_B-alpha	59,74	serine	I kappa B-alpha	CHEBI:17822	4792	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Involvement of a putative protein-tyrosine phosphatase and I_kappa_B-alpha serine phosphorylation in nuclear_factor_kappa_B activation by tumor_necrosis_factor .
7675442	0	serine	144,150	I_kappa_B-alpha	163,178	serine	I kappa B-alpha	CHEBI:17822	4792	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	I_kappa_B-alpha-mediated inhibition of nuclear transport and DNA-binding by Rel proteins are separable functions : phosphorylation of C-terminal serine residues of I_kappa_B-alpha is specifically required for inhibition of DNA-binding .
16195219	0	serine	87,93	IkappaB-alpha	126,139	serine	IkappaB-alpha	CHEBI:17822	4792	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Inhibition of SRC tyrosine kinases suppresses activation of nuclear factor-kappaB , and serine and tyrosine phosphorylation of IkappaB-alpha in lipopolysaccharide-stimulated raw 264.7 macrophages .
16332940	0	serine	65,71	Insulin	0,7	serine	Insulin	CHEBI:17822	3630	Chemical	Gene	phosphorylation|amod|START_ENTITY mediated|nmod|phosphorylation mediated|nsubjpass|resistance resistance|compound|END_ENTITY	Insulin resistance in human preeclamptic placenta is mediated by serine phosphorylation of insulin_receptor_substrate-1_and _ -2 .
2197270	0	serine	84,90	Insulin	0,7	serine	Insulin	CHEBI:17822	3630	Chemical	Gene	phosphorylation|amod|START_ENTITY increasing|dobj|phosphorylation activates|advcl|increasing activates|nsubj|END_ENTITY	Insulin activates the kinase activity of the Raf-1 proto-oncogene by increasing its serine phosphorylation .
6316966	0	serine	38,44	Insulin	0,7	serine	Insulin	CHEBI:17822	3630	Chemical	Gene	residues|amod|START_ENTITY phosphorylation|nmod|residues stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Insulin stimulates phosphorylation of serine residues in soluble insulin receptors .
8496180	0	serine	19,25	Insulin	0,7	serine	Insulin	CHEBI:17822	3630	Chemical	Gene	phosphorylation|amod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Insulin stimulates serine and tyrosine phosphorylation in the juxtamembrane region of the insulin_receptor .
8647800	0	serine	23,29	Insulin	0,7	serine	Insulin	CHEBI:17822	3630	Chemical	Gene	phosphorylation|amod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Insulin stimulates the serine phosphorylation of the signal_transducer_and_activator_of_transcription -LRB- STAT3 -RRB- isoform .
8472865	0	serine	30,36	Insulin_receptor	0,16	serine	Insulin receptor	CHEBI:17822	24954(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Insulin_receptor beta-subunit serine phosphorylation in permeabilized cultured fetal rat hepatocytes .
1850360	0	serine	25,31	Interleukin_2	0,13	serine	Interleukin 2	CHEBI:17822	16183(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Interleukin_2 stimulates serine phosphorylation of CD45 in CTLL-2 .4 cells .
11352573	0	serine	65,71	KLK14	39,44	serine	KLK14	CHEBI:17822	43847	Chemical	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification and characterization of KLK14 , a novel kallikrein serine protease gene located on human chromosome 19q13 .4 and expressed in prostate and skeletal muscle .
10438493	0	serine	56,62	KLK4	78,82	serine	KLK4	CHEBI:17822	9622	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Localization of a new prostate-specific antigen-related serine protease gene , KLK4 , is evidence for an expanded human kallikrein gene family cluster on chromosome 19q13.3-13 .4 .
16202624	0	serine	49,55	LACTB	65,70	serine	LACTB	CHEBI:17822	80907(Tax:10090)	Chemical	Gene	Expression|nmod|START_ENTITY protease|nsubj|Expression protease|dobj|END_ENTITY	Expression and purification of the mitochondrial serine protease LACTB as an N-terminal GST fusion protein in Escherichia_coli .
11943586	0	serine	21,27	LEKTI	0,5	serine	LEKTI	CHEBI:17822	11005	Chemical	Gene	inhibitor|amod|START_ENTITY END_ENTITY|dep|inhibitor	LEKTI : a multidomain serine proteinase inhibitor with pathophysiological relevance .
15485854	0	serine	43,49	Lcb1p	20,25	serine	Lcb1p	CHEBI:17822	855342(Tax:4932)	Chemical	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	The topology of the Lcb1p subunit of yeast serine palmitoyltransferase .
2552997	0	serine	109,115	MAP-2	102,107	serine	MAP-2	CHEBI:17822	4133	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Complexing of the CD-3 subunit by a monoclonal antibody activates a microtubule-associated_protein 2 -LRB- MAP-2 -RRB- serine kinase in Jurkat cells .
8039496	0	serine	44,50	MAP_kinase_kinase	85,102	serine	MAP kinase kinase	CHEBI:17822	5604	Chemical	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Constitutive mutant and putative regulatory serine phosphorylation site of mammalian MAP_kinase_kinase -LRB- MEK1 -RRB- .
12707349	0	serine	44,50	MASP	61,65	serine	MASP	CHEBI:17822	5648	Chemical	Gene	protease|compound|START_ENTITY protease|appos|END_ENTITY	Origin of mannose-binding lectin-associated serine protease -LRB- MASP -RRB- -1 and MASP-3 involved in the lectin complement pathway traced back to the invertebrate , amphioxus .
12847554	0	serine	7,13	MASP-1	24,30	serine	MASP-1	CHEBI:17822	17174(Tax:10090)	Chemical	Gene	proteases|compound|START_ENTITY proteases|amod|END_ENTITY	Murine serine proteases MASP-1 and MASP-3 , components of the lectin pathway activation complex of complement , are encoded by a single structural gene .
12601245	0	serine	64,70	MASP1	81,86	serine	MASP1	CHEBI:17822	5648	Chemical	Gene	protease|compound|START_ENTITY protease|appos|END_ENTITY	Detection of a processed pseudogene of the human MBL-associated serine protease , MASP1 .
12763138	0	serine	23,29	MEK	95,98	serine	MEK	CHEBI:17822	5609	Chemical	Gene	phosphorylation|amod|START_ENTITY mediated|nsubj|phosphorylation mediated|nmod|END_ENTITY	Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK - , ERK - , and MSK1-dependent pathway .
15358159	0	serine	38,44	MEK	0,3	serine	MEK	CHEBI:17822	5609	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	MEK inhibition and phosphorylation of serine 4 on B23 are two coincident events in mitosis .
8034665	0	serine	20,26	MEK-1	39,44	serine	MEK-1	CHEBI:17822	170851(Tax:10116)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Identification of 2 serine residues of MEK-1 that are differentially phosphorylated during activation by raf and MEK kinase .
15020250	0	serine	46,52	Mammalian_target_of_rapamycin	0,29	serine	Mammalian target of rapamycin	CHEBI:17822	2475	Chemical	Gene	phosphorylation|amod|START_ENTITY regulates|dobj|phosphorylation regulates|nsubj|END_ENTITY	Mammalian_target_of_rapamycin regulates IRS-1 serine 307 phosphorylation .
18424734	0	serine	40,46	Mannose-binding_lectin	0,22	serine	Mannose-binding lectin	CHEBI:17822	17195(Tax:10090)	Chemical	Gene	protease|amod|START_ENTITY END_ENTITY|dep|protease	Mannose-binding_lectin -LRB- MBL -RRB- - associated serine protease -LRB- MASP -RRB- -1 contributes to activation of the lectin complement pathway .
7731720	0	serine	64,70	Mek-1	55,60	serine	Mek-1	CHEBI:17822	5604	Chemical	Gene	residues|amod|START_ENTITY END_ENTITY|nmod|residues	B-Raf protein isoforms interact with and phosphorylate Mek-1 on serine residues 218 and 222 .
16818610	0	serine	26,32	MuSK	52,56	serine	MuSK	CHEBI:17822	18198(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Casein kinase 2-dependent serine phosphorylation of MuSK regulates acetylcholine receptor aggregation at the neuromuscular junction .
24741082	0	serine	36,42	NEP	100,103	serine	NEP	CHEBI:17822	4311	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	Phosphorylation of highly conserved serine residues in the influenza_A_virus nuclear_export_protein NEP plays a minor role in viral growth in human cells and mice .
19789307	0	serine	41,47	NF-kappaB	8,17	serine	NF-kappaB	CHEBI:17822	4790	Chemical	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Nuclear NF-kappaB p65 phosphorylation at serine 276 by protein kinase A contributes to the malignant phenotype of head_and_neck_cancer .
20966071	0	serine	45,51	NF-kappaB	23,32	serine	NF-kappaB	CHEBI:17822	4790	Chemical	Gene	residue|compound|START_ENTITY END_ENTITY|nmod|residue	Phosphorylation of p50 NF-kappaB at a single serine residue by DNA-dependent_protein_kinase is critical for VCAM-1 expression upon TNF treatment .
20667449	0	serine	47,53	NR1	95,98	serine	NR1	CHEBI:17822	24408(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Metabotropic glutamate mGlu5 receptor-mediated serine phosphorylation of NMDA receptor subunit NR1 in hippocampal CA1 region after transient global ischemia in rats .
12505640	0	serine	52,58	NS3	48,51	serine	NS3	CHEBI:17822	3845	Chemical	Gene	START_ENTITY|nsubj|assay assay|nmod|END_ENTITY	A novel high throughput screening assay for HCV NS3 serine protease inhibitors .
12646587	0	serine	7,13	NS3	3,6	serine	NS3	CHEBI:17822	3845	Chemical	Gene	inhibitor|compound|START_ENTITY inhibitor|compound|END_ENTITY	An NS3 serine protease inhibitor abrogates replication of subgenomic hepatitis_C_virus RNA .
17921146	0	serine	4,10	NS3	48,51	serine	NS3	CHEBI:17822	3845	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	The serine protease domain of hepatitis_C viral NS3 activates RNA helicase activity by promoting the binding of RNA substrate .
23773863	0	serine	54,60	NS3	50,53	serine	NS3	CHEBI:17822	3845	Chemical	Gene	analogs|compound|START_ENTITY analogs|compound|END_ENTITY	Peptide backbone replacement_of_hepatitis_C virus NS3 serine protease C-terminal cleavage product analogs : discovery of potent succinamide inhibitors .
7747484	0	serine	44,50	NS3	40,43	serine	NS3	CHEBI:17822	3845	Chemical	Gene	START_ENTITY|nsubj|assay assay|nmod|END_ENTITY	An in vitro assay for hepatitis_C virus NS3 serine proteinase .
9010283	0	serine	45,51	NS3	41,44	serine	NS3	CHEBI:17822	3845	Chemical	Gene	domain|amod|START_ENTITY domain|compound|END_ENTITY	Purification and characterization of the NS3 serine protease domain of hepatitis_C virus expressed in Saccharomyces_cerevisiae .
9188600	0	serine	32,38	NS3	28,31	serine	NS3	CHEBI:17822	3845	Chemical	Gene	proteinase|amod|START_ENTITY END_ENTITY|amod|proteinase	Bovine_viral_diarrhea_virus NS3 serine proteinase : polyprotein cleavage sites , cofactor requirements , and molecular model of an enzyme essential for pestivirus replication .
8245015	0	serine	2,8	Nm23	28,32	serine	Nm23	CHEBI:17822	4830	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	A serine phosphorylation of Nm23 , and not its nucleoside_diphosphate_kinase activity , correlates with suppression of tumor metastatic potential .
26291278	0	serine	46,52	Nrf2	26,30	serine	Nrf2	CHEBI:17822	4780	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|END_ENTITY	Coordinated regulation of Nrf2 and histone H3 serine 10 phosphorylation in arsenite-activated transcription of the human heme_oxygenase-1 gene .
11507231	0	serine	37,43	ORF47	23,28	serine	ORF47	CHEBI:17822	1487678(Tax:10335)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Varicella-zoster_virus ORF47 protein serine kinase : characterization of a cloned , biologically active phosphotransferase and two viral substrates , ORF62 and ORF63 .
15687493	0	serine	59,65	P450c17	85,92	serine	P450c17	CHEBI:17822	1586	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Regulation of 17,20 lyase activity by cytochrome b5 and by serine phosphorylation of P450c17 .
21825134	0	serine	44,50	PI3K	70,74	serine	PI3K	CHEBI:17822	5295	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Inhibition of PI3K binding to activators by serine phosphorylation of PI3K regulatory subunit p85alpha Src homology-2 domains .
10435626	0	serine	10,16	PIM-1	4,9	serine	PIM-1	CHEBI:17822	18712(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The PIM-1 serine kinase prolongs survival and inhibits apoptosis-related mitochondrial_dysfunction in part through a bcl-2-dependent pathway .
11457471	0	serine	43,49	PN-1	88,92	serine	PN-1	CHEBI:17822	29366(Tax:10116)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Increased expression and localization of a serine protease inhibitor , protease_nexin-1 -LRB- PN-1 -RRB- , in the ovary and uterus during implantation in rat .
17827166	0	serine	24,30	PN-1	62,66	serine	PN-1	CHEBI:17822	707121(Tax:9544)	Chemical	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of prostasin serine protease and protease_nexin-1 -LRB- PN-1 -RRB- in rhesus_monkey ovary during menstrual cycle and early pregnancy .
10662548	0	serine	90,96	PRSS20	112,118	serine	PRSS20	CHEBI:17822	11012	Chemical	Gene	protease|compound|START_ENTITY protease|appos|END_ENTITY	Genomic organization , mapping , tissue expression , and hormonal regulation of trypsin-like serine protease -LRB- TLSP PRSS20 -RRB- , a new member of the human kallikrein gene family .
25537662	5	serine	806,812	PSMA	927,931	serine	PSMA	CHEBI:17822	2346	Chemical	Gene	_|amod|START_ENTITY _|appos|END_ENTITY	The inactivating acidic peptide domain was engineered to be a cleavable substrate for the secreted serine protease prostate-specific_antigen _ -LRB- PSA -RRB- or the transmembrane metalloprotease prostate-specific_membrane_antigen -LRB- PSMA -RRB- .
11756316	0	serine	108,114	PTP-1B	134,140	serine	PTP-1B	CHEBI:17822	5770	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	A P387L variant in protein_tyrosine_phosphatase-1B -LRB- PTP-1B -RRB- is associated with type 2 diabetes and impaired serine phosphorylation of PTP-1B in vitro .
17008371	0	serine	115,121	PTP1B	99,104	serine	PTP1B	CHEBI:17822	24697(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Reversal of diet-induced insulin resistance with a single bout of exercise in the rat : the role of PTP1B and IRS-1 serine phosphorylation .
16116087	0	serine	23,29	Pleiotrophin	0,12	serine	Pleiotrophin	CHEBI:17822	5764	Chemical	Gene	phosphorylation|amod|START_ENTITY regulates|dobj|phosphorylation regulates|nsubj|END_ENTITY	Pleiotrophin regulates serine phosphorylation and the cellular distribution of beta-adducin through activation of protein kinase C. Pleiotrophin -LRB- PTN -RRB- was found to regulate tyrosine phosphorylation of beta-adducin through the PTN/receptor protein tyrosine phosphatase -LRB- RPTP -RRB- beta/zeta signaling pathway .
23046929	0	serine	24,30	Plk1	11,15	serine	Plk1	CHEBI:17822	5347	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	-LSB- Effect of Plk1 330/597 serine phosphorylated mutant on cytokinesis during mitosis -RSB- .
20406818	0	serine	23,29	RIG-I	17,22	serine	RIG-I	CHEBI:17822	23586	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	Negative role of RIG-I serine 8 phosphorylation in the regulation of interferon-beta production .
2307850	0	serine	42,48	RNKP-1	0,6	serine	RNKP-1	CHEBI:17822	171528(Tax:10116)	Chemical	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	RNKP-1 , a novel natural killer-associated serine protease gene cloned from RNK-16 cytotoxic lymphocytes .
1386920	0	serine	113,119	Raf-1	89,94	serine	Raf-1	CHEBI:17822	24703(Tax:10116)	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Ras controls coupling of growth factor receptors and protein kinase C in the membrane to Raf-1 and B-Raf protein serine kinases in the cytosol .
12874295	0	serine	22,28	RelB	17,21	serine	RelB	CHEBI:17822	19698(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	Critical role of RelB serine 368 for dimerization and p100 stabilization .
17050626	0	serine	21,27	Ret	39,42	serine	Ret	CHEBI:17822	19713(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|kinase kinase|compound|END_ENTITY	Targeted mutation of serine 697 in the Ret tyrosine kinase causes migration_defect_of_enteric_neural_crest cells .
20977773	0	serine	33,39	SERPINE2	60,68	serine	SERPINE2	CHEBI:17822	20720(Tax:10090)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Spatiotemporal expression of the serine protease inhibitor , SERPINE2 , in the mouse placenta and uterus during the estrous cycle , pregnancy , and lactation .
15260483	0	serine	30,36	SLBP	71,75	serine	SLBP	CHEBI:17822	43448(Tax:7227)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Electrostatic contribution of serine phosphorylation to the Drosophila SLBP -- histone mRNA complex .
19194479	0	serine	46,52	SPINK9	0,6	serine	SPINK9	CHEBI:17822	643394	Chemical	Gene	inhibitor|compound|START_ENTITY END_ENTITY|dep|inhibitor	SPINK9 : a selective , skin-specific Kazal-type serine protease inhibitor .
18715980	0	serine	21,27	SPINKL	0,6	serine	SPINKL	CHEBI:17822	77424(Tax:10090)	Chemical	Gene	protein|amod|START_ENTITY END_ENTITY|appos|protein	SPINKL , a Kazal-type serine protease inhibitor-like protein purified from mouse seminal vesicle fluid , is able to inhibit sperm capacitation .
19592499	0	serine	62,68	SPTLC1	32,38	serine	SPTLC1	CHEBI:17822	10558	Chemical	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Cell polarity factor Par3 binds SPTLC1 and modulates monocyte serine palmitoyltransferase activity and chemotaxis .
10523304	0	serine	37,43	STAT1	31,36	serine	STAT1	CHEBI:17822	6772	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	p38 MAP kinase is required for STAT1 serine phosphorylation and transcriptional activation induced by interferons .
12018856	0	serine	10,16	STAT1	51,56	serine	STAT1	CHEBI:17822	6772	Chemical	Gene	START_ENTITY|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Increased serine phosphorylation and activation of STAT1 by oncogenic Ras transfection .
12811837	0	serine	80,86	STAT1	91,96	serine	STAT1	CHEBI:17822	6772	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|compound|END_ENTITY	Triggering of Toll-like receptors modulates IFN-gamma signaling : involvement of serine 727 STAT1 phosphorylation and suppressors of cytokine signaling .
24449862	0	serine	67,73	STAT1	93,98	serine	STAT1	CHEBI:17822	6772	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Novel antiviral host factor , TNK1 , regulates IFN signaling through serine phosphorylation of STAT1 .
7791765	0	serine	26,32	STAT1	52,57	serine	STAT1	CHEBI:17822	6772	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Differentiation-regulated serine phosphorylation of STAT1 promotes GAF activation in macrophages .
10347203	0	serine	101,107	STAT3	73,78	serine	STAT3	CHEBI:17822	6774	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Activated G protein-coupled receptor induces tyrosine phosphorylation of STAT3 and agonist-selective serine phosphorylation via sustained stimulation of mitogen-activated protein kinase .
12681450	0	serine	42,48	STAT3	36,41	serine	STAT3	CHEBI:17822	6774	Chemical	Gene	START_ENTITY|nsubj|activation activation|nmod|END_ENTITY	IL-2 activation of a PI3K-dependent STAT3 serine phosphorylation pathway in primary human T cells .
12763138	0	serine	23,29	STAT3	53,58	serine	STAT3	CHEBI:17822	6774	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK - , ERK - , and MSK1-dependent pathway .
15325847	0	serine	63,69	STAT3	89,94	serine	STAT3	CHEBI:17822	6774	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Activation of formyl peptide receptor-like 1 by WKYMVm induces serine phosphorylation of STAT3 , which inhibits its tyrosine phosphorylation and nuclear translocation induced by hydrogen_peroxide .
19331815	0	serine	112,118	STAT3	138,143	serine	STAT3	CHEBI:17822	6774	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	mTOR mediates human trophoblast invasion through regulation of matrix-remodeling enzymes and is associated with serine phosphorylation of STAT3 .
24312439	0	serine	37,43	STAT3	77,82	serine	STAT3	CHEBI:17822	6774	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	The MEK-ERK pathway is necessary for serine phosphorylation of mitochondrial STAT3 and Ras-mediated transformation .
24263804	0	serine	20,26	STAT5	14,19	serine	STAT5	CHEBI:17822	6776	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	PAK-dependent STAT5 serine phosphorylation is required for BCR-ABL-induced leukemogenesis .
9388190	0	serine	143,149	Shc	169,172	serine	Shc	CHEBI:17822	20416(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	12-O-Tetradecanoylphorbol-13-acetate activates the Ras/extracellular _ signal-regulated_kinase -LRB- ERK -RRB- signaling pathway upstream of SOS involving serine phosphorylation of Shc in NIH3T3 cells .
9322921	0	serine	51,57	Signal_transducer_and_activator_of_transcription-3	0,50	serine	Signal transducer and activator of transcription-3	CHEBI:17822	6774	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Signal_transducer_and_activator_of_transcription-3 serine phosphorylation by insulin is mediated by a Ras/Raf/MEK-dependent pathway .
23416984	0	serine	32,38	Slingshot_2	13,24	serine	Slingshot 2	CHEBI:17822	85464	Chemical	Gene	phosphatase|amod|START_ENTITY END_ENTITY|amod|phosphatase	Knockdown of Slingshot_2 -LRB- SSH2 -RRB- serine phosphatase induces Caspase3 activation in human carcinoma cell lines with the loss of the Birt-Hogg-Dub tumour suppressor gene -LRB- FLCN -RRB- .
11509558	3	serine	265,271	Smad1	259,264	serine	Smad1	CHEBI:17822	4086	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	BMP addition triggers Smad1 serine phosphorylation , binding of Smad4 , and its accumulation in the nucleus .
8143911	0	serine	18,24	Spi-1	0,5	serine	Spi-1	CHEBI:17822	299282(Tax:10116)	Chemical	Gene	inhibitor|amod|START_ENTITY END_ENTITY|dep|inhibitor	Spi-1 : an hepatic serine protease inhibitor regulated by GH and other hormones .
10878008	4	serine	950,956	Stat1	976,981	serine	Stat3	CHEBI:17822	6774	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	In studies to determine whether the regulatory effects of p38 are mediated by serine phosphorylation of Stat1 or Stat3 , we found that the p38 kinase inhibitors SB203580 or SB202190 or overexpression of a dominant negative p38 mutant do not inhibit phosphorylation of Stat1 or Stat3 on Ser-727 in several IFNalpha-sensitive cell lines .
12748293	0	serine	115,121	Stat1	145,150	serine	Stat1	CHEBI:17822	6772	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Interleukin-13 induction of 15-lipoxygenase gene expression requires p38_mitogen-activated_protein_kinase-mediated serine 727 phosphorylation of Stat1 and Stat3 .
9343425	0	serine	6,12	Stat1	0,5	serine	Stat1	CHEBI:17822	6772	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Stat1 serine phosphorylation occurs independently of tyrosine phosphorylation and requires an activated Jak2 kinase .
8704168	0	serine	21,27	Stat3	47,52	serine	Stat3	CHEBI:17822	6774	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Steel_factor induces serine phosphorylation of Stat3 in human growth factor-dependent myeloid cell lines .
9144332	0	serine	32,38	Stat3	79,84	serine	Stat3	CHEBI:17822	25125(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Angiotensin_II stimulates rapid serine phosphorylation of transcription factor Stat3 .
9153303	0	serine	17,23	Stat3	11,16	serine	Stat3	CHEBI:17822	6774	Chemical	Gene	START_ENTITY|nsubj|Mapping Mapping|nmod|END_ENTITY	Mapping of Stat3 serine phosphorylation to a single residue -LRB- 727 -RRB- and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3 .
8704168	0	serine	21,27	Steel_factor	0,12	serine	Steel factor	CHEBI:17822	4254	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Steel_factor induces serine phosphorylation of Stat3 in human growth factor-dependent myeloid cell lines .
15044063	0	serine	33,39	SynGAP	102,108	serine	SynGAP	CHEBI:17822	192117(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	PSD-95 promotes CaMKII-catalyzed serine phosphorylation of the synaptic_RAS-GTPase_activating_protein SynGAP after transient brain_ischemia in rat hippocampus .
24534530	0	serine	87,93	TAK1	82,86	serine	TAK1	CHEBI:17822	26409(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|compound|END_ENTITY	Phosphatase holoenzyme PP1/GADD34 negatively regulates TLR response by inhibiting TAK1 serine 412 phosphorylation .
8620895	0	serine	27,33	TL2	53,56	serine	TL2	CHEBI:17822	8743	Chemical	Gene	protease|compound|START_ENTITY protease|appos|END_ENTITY	T-cell membrane-associated serine protease , tryptase TL2 , binds human_immunodeficiency_virus_type_1 gp120 and cleaves the third-variable-domain loop of gp120 .
10485450	0	serine	75,81	TMPRSS2	91,98	serine	TMPRSS2	CHEBI:17822	7113	Chemical	Gene	expression|nmod|START_ENTITY protease|nsubj|expression protease|dobj|END_ENTITY	Prostate-localized and androgen-regulated expression of the membrane-bound serine protease TMPRSS2 .
11169526	0	serine	28,34	TMPRSS2	44,51	serine	TMPRSS2	CHEBI:17822	50528(Tax:10090)	Chemical	Gene	Expression|nmod|START_ENTITY protease|nsubj|Expression protease|dobj|END_ENTITY	Expression of transmembrane serine protease TMPRSS2 in mouse and human tissues .
23740979	0	serine	97,103	TRIM28	177,183	serine	TRIM28	CHEBI:17822	10155	Chemical	Gene	inactivation|amod|START_ENTITY inactivation|nmod|END_ENTITY	Kaposi 's _ sarcoma-associated_herpesvirus kaposin_B induces unique monophosphorylation of STAT3 at serine 727 and MK2-mediated inactivation of the STAT3 transcriptional repressor TRIM28 .
24791141	0	serine	26,32	Tmprss6	56,63	serine	Tmprss6	CHEBI:17822	71753(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY protease|nsubj|expression protease|dobj|END_ENTITY	Retinal expression of the serine protease matriptase-2 -LRB- Tmprss6 -RRB- and its role in retinal iron homeostasis .
20729278	0	serine	67,73	Tssk	82,86	serine	Tssk	CHEBI:17822	22114(Tax:10090)	Chemical	Gene	family|amod|START_ENTITY family|appos|END_ENTITY	Expression and localization of five members of the testis-specific serine kinase -LRB- Tssk -RRB- family in mouse and human sperm and testis .
17684042	0	serine	19,25	VASP	14,18	serine	VASP	CHEBI:17822	7408	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of VASP serine 157 phosphorylation in human neutrophils after stimulation by a chemoattractant .
24779009	0	serine	74,80	VASP	50,54	serine	VASP	CHEBI:17822	7408	Chemical	Gene	phosphorylation|nmod|START_ENTITY END_ENTITY|dobj|phosphorylation	A short-term incubation with high glucose impairs VASP phosphorylation at serine 239 in response to the nitric_oxide / cGMP pathway in vascular smooth muscle cells : role of oxidative stress .
20802512	0	serine	52,58	Y-box_binding_protein-1	28,51	serine	Y-box binding protein-1	CHEBI:17822	4904	Chemical	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	The expression of activated Y-box_binding_protein-1 serine 102 mediates trastuzumab resistance in breast_cancer cells by increasing CD44 + cells .
7608200	0	serine	50,56	acetyltransferase	57,74	serine	acetyltransferase	CHEBI:17822	20468107	Chemical	Gene	cloning|nmod|START_ENTITY END_ENTITY|nsubj|cloning	Molecular cloning and characterization of a plant serine acetyltransferase playing a regulatory role in cysteine biosynthesis from watermelon .
22394463	2	serine	531,537	alanine	514,521	serine	RASSF1A	CHEBI:17822	11186	Chemical	Gene	determines|nmod|START_ENTITY determines|dobj|END_ENTITY	A_guanine -LRB- G -RRB- / thymine -LRB- T -RRB- common single nucleotide polymorphism -LRB- SNP -RRB- at first position of codon 133 in RASSF1A gene determines an alanine -LRB- Ala -RRB- to serine -LRB- Ser -RRB- -LRB- Ala133Ser -RRB- amino acidic substitution which may alter cancer risk by influencing the function of RASSF1A protein .
18511414	0	serine	32,38	androgen_receptor	14,31	serine	androgen receptor	CHEBI:17822	367	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Site-specific androgen_receptor serine phosphorylation linked to epidermal_growth_factor-dependent growth of castration-recurrent prostate_cancer .
19940161	0	serine	12,18	angiotensin_II	72,86	serine	angiotensin II	CHEBI:17822	183	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	PGC-1_alpha serine 570 phosphorylation and GCN5-mediated acetylation by angiotensin_II drive catalase down-regulation and vascular hypertrophy .
18412141	0	serine	54,60	annexin_A2	101,111	serine	annexin A2	CHEBI:17822	302	Chemical	Gene	START_ENTITY|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Epstein-Barr_virus latent_membrane_protein_1 mediates serine 25 phosphorylation and nuclear entry of annexin_A2 via PI-PLC-PKCalpha/PKCbeta pathway .
7476280	0	serine	14,20	apolipoprotein_B	141,157	serine	apolipoprotein B	CHEBI:17822	338	Chemical	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|END_ENTITY	Comparison of serine and hippurate as precursor equivalents during infusion of -LSB- 15N -RSB- glycine for measurement of fractional synthetic rates of apolipoprotein_B of very-low-density lipoprotein .
1368488	0	serine	12,18	basic_fibroblast_growth_factor	36,66	serine	basic fibroblast growth factor	CHEBI:17822	2247	Chemical	Gene	substitutions|amod|START_ENTITY substitutions|nmod|END_ENTITY	Cysteine to serine substitutions in basic_fibroblast_growth_factor : effect on inclusion body formation and proteolytic susceptibility during in vitro refolding .
11027724	0	serine	85,91	brassinosteroid	12,27	serine	brassinosteroid	CHEBI:17822	830095(Tax:3702)	Chemical	Gene	residues|amod|START_ENTITY END_ENTITY|nmod|residues	Recombinant brassinosteroid insensitive_1 receptor-like kinase autophosphorylates on serine and threonine residues and phosphorylates a conserved peptide motif in vitro .
23624790	2	serine	387,393	c-Met	413,418	serine	c-Met	CHEBI:17822	4233	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	We have previously shown that lysophosphatidic_acid -LRB- LPA -RRB- induced a decrease in c-Met activation via serine phosphorylation of c-Met at cell-cell contacts .
10521702	0	serine	14,20	cPLA2	40,45	serine	cPLA2	CHEBI:17822	18783(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	IL-13 induces serine phosphorylation of cPLA2 in mouse peritoneal macrophages leading to arachidonic_acid and PGE2 production and blocks the zymosan-induced serine phosphorylation of cPLA2 and eicosanoid production .
11726805	0	serine	39,45	cdc2	66,70	serine	cdc2	CHEBI:17822	983	Chemical	Gene	residue|amod|START_ENTITY residue|nmod|END_ENTITY	Phosphorylation of amyloid-beta at the serine 26 residue by human cdc2 kinase .
23973256	0	serine	15,21	connexin43	41,51	serine	connexin43	CHEBI:17822	24392(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	PKC mediates serine phosphorylation of connexin43 induced by lysophosphatidylcholine in neonatal rat cardiomyocytes .
24013421	0	serine	6,12	cyclin-dependent_kinase_1	36,61	serine	cyclin-dependent kinase 1	CHEBI:17822	983	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Ubp-M serine 552 phosphorylation by cyclin-dependent_kinase_1 regulates cell cycle progression .
15572662	0	serine	41,47	cyclin-dependent_protein_kinase_2	134,167	serine	cyclin-dependent protein kinase 2	CHEBI:17822	1017	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Phosphorylation of progesterone receptor serine 400 mediates ligand-independent transcriptional activity in response to activation of cyclin-dependent_protein_kinase_2 .
7649158	0	serine	38,44	cytosolic_phospholipase_A2	125,151	serine	cytosolic phospholipase A2	CHEBI:17822	5321	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Epidermal_growth_factor -LRB- EGF -RRB- induces serine phosphorylation-dependent activation and calcium-dependent translocation of the cytosolic_phospholipase_A2 .
22512582	0	serine	6,12	dipeptidyl_peptidase_IV	22,45	serine	dipeptidyl peptidase IV	CHEBI:17822	1803	Chemical	Gene	inhibitor|compound|START_ENTITY inhibitor|compound|END_ENTITY	Novel serine protease dipeptidyl_peptidase_IV inhibitor : alogliptin .
23161550	0	serine	40,46	dopamine_transporter	19,39	serine	dopamine transporter	CHEBI:17822	24898(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation of dopamine_transporter serine 7 modulates cocaine analog binding .
7512621	0	serine	13,19	dystrophin	39,49	serine	dystrophin	CHEBI:17822	1756	Chemical	Gene	START_ENTITY|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Tyrosine and serine phosphorylation of dystrophin and the 58-kDa protein in the postsynaptic membrane of Torpedo electric organ .
1403850	0	serine	37,43	eIF-4E	99,105	serine	eIF-4E	CHEBI:17822	1977	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Protein kinase C phosphorylates both serine and threonine residues of the mRNA_cap_binding_protein eIF-4E .
11041858	0	serine	19,25	eIF2_alpha	59,69	serine	eIF2 alpha	CHEBI:17822	100338417(Tax:9986)	Chemical	Gene	START_ENTITY|nmod|factor factor|appos|END_ENTITY	Phosphorylation of serine 51 in initiation factor 2 alpha -LRB- eIF2_alpha -RRB- promotes complex formation between eIF2_alpha -LRB- P -RRB- and eIF2B and causes inhibition in the guanine_nucleotide exchange activity of eIF2B .
25497381	0	serine	49,55	eIF2a	43,48	serine	eIF2a	CHEBI:17822	1965	Chemical	Gene	START_ENTITY|nsubj|Roles Roles|nmod|END_ENTITY	Roles of the translation initiation factor eIF2a serine 51 phosphorylation in cancer formation and treatment .
25795854	0	serine	100,106	eIF2a	94,99	serine	eIF2a	CHEBI:17822	1965	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	P5 .03 Control of cell fate by the mammalian_target_of_rapamycin -LRB- mTOR -RRB- under stress depends on eIF2a serine 51 phosphorylation .
9792652	0	serine	40,46	eIF4E	19,24	serine	eIF4E	CHEBI:17822	1977	Chemical	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of eIF4E at a conserved serine in Aplysia .
23220022	0	serine	55,61	epidermal_growth_factor_receptor	19,51	serine	epidermal growth factor receptor	CHEBI:17822	1956	Chemical	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	Phosphorylation of epidermal_growth_factor_receptor at serine 1047 by MAP_kinase-activated_protein_kinase-2 in cultured lung epithelial cells treated with flagellin .
17615152	0	serine	13,19	estrogen_receptor-alpha	48,71	serine	estrogen receptor-alpha	CHEBI:17822	2099	Chemical	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	A functional serine 118 phosphorylation site in estrogen_receptor-alpha is required for down-regulation of gene expression by 17beta-estradiol and 4-hydroxytamoxifen .
18550720	0	serine	104,110	estrogen_receptor_alpha	23,46	serine	estrogen receptor alpha	CHEBI:17822	2099	Chemical	Gene	START_ENTITY|nsubj|phosphorylation phosphorylation|nmod|END_ENTITY	Low phosphorylation of estrogen_receptor_alpha -LRB- ERalpha -RRB- serine 118 and high phosphorylation of ERalpha serine 167 improve survival in ER-positive breast_cancer .
18838540	0	serine	40,46	glucocorticoid_receptor	76,99	serine	glucocorticoid receptor	CHEBI:17822	2908	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Glycogen_synthase_kinase_3beta-mediated serine phosphorylation of the human glucocorticoid_receptor redirects gene expression profiles .
15659239	0	serine	72,78	glycogen_synthase_kinase-3	98,124	serine	glycogen synthase kinase-3	CHEBI:17822	56637(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Anesthesia and post-mortem interval profoundly influence the regulatory serine phosphorylation of glycogen_synthase_kinase-3 in mouse brain .
17709562	0	serine	39,45	glycogen_synthase_kinase-3alpha	69,100	serine	glycogen synthase kinase-3alpha	CHEBI:17822	536561(Tax:9913)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Porcine sperm motility is regulated by serine phosphorylation of the glycogen_synthase_kinase-3alpha .
1700699	0	serine	104,110	granulocyte-macrophage_colony-stimulating_factor	47,95	serine	granulocyte-macrophage colony-stimulating factor	CHEBI:17822	1437	Chemical	Gene	phosphorylation|amod|START_ENTITY END_ENTITY|nmod|phosphorylation	Signal transduction of human interleukin_3 and granulocyte-macrophage_colony-stimulating_factor through serine and tyrosine phosphorylation .
9701563	0	serine	25,31	granzyme_A	41,51	serine	granzyme A	CHEBI:17822	14938(Tax:10090)	Chemical	Gene	protease|amod|START_ENTITY END_ENTITY|amod|protease	Nuclear targeting of the serine protease granzyme_A -LRB- fragmentin-1 -RRB- .
11562487	0	serine	74,80	granzyme_B	16,26	serine	granzyme B	CHEBI:17822	3002	Chemical	Gene	PI-9|amod|START_ENTITY overexpression|nmod|PI-9 perforin|nmod|overexpression Blockade|dep|perforin Blockade|nmod|END_ENTITY	Blockade of the granzyme_B / perforin pathway through overexpression of the serine protease inhibitor PI-9 / SPI-6 constitutes a mechanism for immune escape by tumors .
14578460	0	serine	115,121	granzyme_B	131,141	serine	granzyme B	CHEBI:17822	3002	Chemical	Gene	protease|amod|START_ENTITY END_ENTITY|amod|protease	Mechanistic studies of a novel human fusion toxin composed of vascular_endothelial_growth_factor -LRB- VEGF -RRB- 121 and the serine protease granzyme_B : directed apoptotic events in vascular endothelial cells .
17982045	0	serine	128,134	granzyme_B	71,81	serine	granzyme B	CHEBI:17822	14939(Tax:10090)	Chemical	Gene	inhibitor|amod|START_ENTITY expression|nmod|inhibitor induces|dobj|expression induces|nsubj|expression expression|nmod|END_ENTITY	Intrahepatic lymphocyte expression of dipeptidyl peptidase I-processed granzyme_B and perforin induces hepatocyte expression of serine proteinase inhibitor 6 -LRB- Serpinb9/SPI -6 -RRB- .
8449211	0	serine	32,38	granzyme_B	48,58	serine	granzyme B	CHEBI:17822	3002	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	A promoter element of the human serine esterase granzyme_B gene controls specific transcription in activated T cells .
9872403	0	serine	20,26	granzyme_B	98,108	serine	granzyme B	CHEBI:17822	171528(Tax:10116)	Chemical	Gene	inhibitor|compound|START_ENTITY expressed|nsubj|inhibitor expressed|nmod|complexes complexes|nmod|END_ENTITY	A new intracellular serine protease inhibitor expressed in the rat pituitary gland complexes with granzyme_B .
17102136	0	serine	31,37	haptoglobin	57,68	serine	haptoglobin	CHEBI:17822	3240	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	A unique loop extension in the serine protease domain of haptoglobin is essential for CD163 recognition of the haptoglobin-hemoglobin complex .
8142647	0	serine	130,136	heat_shock_protein	166,184	serine	heat shock protein	CHEBI:17822	3315	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Interleukin-3_and_granulocyte-macrophage_colony-stimulating_factor induce activation of the MAPKAP_kinase_2 resulting in in vitro serine phosphorylation of the small heat_shock_protein -LRB- Hsp_27 -RRB- .
14641015	0	serine	76,82	insulin	125,132	serine	insulin	CHEBI:17822	3630	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|retroregulation retroregulation|nmod|signalling signalling|compound|END_ENTITY	Fatty_acid-induced insulin resistance : role of insulin_receptor_substrate_1 serine phosphorylation in the retroregulation of insulin signalling .
14641015	0	serine	76,82	insulin	19,26	serine	insulin	CHEBI:17822	3630	Chemical	Gene	phosphorylation|compound|START_ENTITY role|nmod|phosphorylation resistance|dep|role resistance|compound|END_ENTITY	Fatty_acid-induced insulin resistance : role of insulin_receptor_substrate_1 serine phosphorylation in the retroregulation of insulin signalling .
16129690	0	serine	63,69	insulin	34,41	serine	insulin	CHEBI:17822	3630	Chemical	Gene	START_ENTITY|nsubj|Attenuation Attenuation|nmod|substrate-1 substrate-1|compound|END_ENTITY	Attenuation of insulin-stimulated insulin receptor substrate-1 serine 307 phosphorylation in insulin resistance of type 2 diabetes .
16129690	0	serine	63,69	insulin	93,100	serine	insulin	CHEBI:17822	3630	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	Attenuation of insulin-stimulated insulin receptor substrate-1 serine 307 phosphorylation in insulin resistance of type 2 diabetes .
16516141	0	serine	27,33	insulin	68,75	serine	insulin	CHEBI:17822	3630	Chemical	Gene	IRS1|nmod|START_ENTITY Phosphorylation|nmod|IRS1 307|nsubj|Phosphorylation 307|nmod|END_ENTITY	Phosphorylation of IRS1 at serine 307 and serine 312 in response to insulin in human adipocytes .
1652474	0	serine	10,16	insulin	40,47	serine	insulin	CHEBI:17822	3630	Chemical	Gene	START_ENTITY|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Multisite serine phosphorylation of the insulin and IGF-I_receptors in transfected cells .
16873706	0	serine	44,50	insulin	24,31	serine	insulin	CHEBI:17822	3630	Chemical	Gene	phosphorylation|amod|START_ENTITY mechanisms|dep|phosphorylation mechanisms|nmod|resistance resistance|compound|END_ENTITY	Molecular mechanisms of insulin resistance : serine phosphorylation of insulin_receptor_substrate-1 and increased expression of p85alpha : the two sides of a coin .
20594757	0	serine	94,100	insulin	21,28	serine	insulin	CHEBI:17822	3630	Chemical	Gene	residues|amod|START_ENTITY substrate-1|nmod|residues phosphorylation|nmod|substrate-1 mediates|nmod|phosphorylation mediates|dobj|resistance resistance|compound|END_ENTITY	mTOR partly mediates insulin resistance by phosphorylation of insulin receptor substrate-1 on serine -LRB- 307 -RRB- residues after burn .
20594757	0	serine	94,100	insulin	62,69	serine	insulin	CHEBI:17822	3630	Chemical	Gene	residues|amod|START_ENTITY substrate-1|nmod|residues substrate-1|compound|END_ENTITY	mTOR partly mediates insulin resistance by phosphorylation of insulin receptor substrate-1 on serine -LRB- 307 -RRB- residues after burn .
23565163	0	serine	27,33	insulin	53,60	serine	insulin	CHEBI:17822	3630	Chemical	Gene	307|amod|START_ENTITY 307|nmod|response response|nmod|END_ENTITY	Phosphorylation of IRS1 at serine 307 in response to insulin in human adipocytes is not likely to be catalyzed by p70 ribosomal S6 kinase .
26604643	0	serine	65,71	insulin	32,39	serine	insulin	CHEBI:17822	3630	Chemical	Gene	phosphorylation|compound|START_ENTITY promotes|nmod|phosphorylation promotes|dobj|resistance resistance|compound|END_ENTITY	Hepatitis_C_virus_NS5A promotes insulin resistance through IRS-1 serine phosphorylation and increased gluconeogenesis .
3146495	0	serine	25,31	insulin	103,110	serine	insulin	CHEBI:17822	3630	Chemical	Gene	changes|acl|START_ENTITY amino_acid|nsubj|changes amino_acid|nmod|treatment treatment|compound|END_ENTITY	Rapid changes in urinary serine and branched-chain amino_acid excretion among diabetic patients during insulin treatment .
6316966	0	serine	38,44	insulin	65,72	serine	insulin	CHEBI:17822	3630	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|receptors receptors|compound|END_ENTITY	Insulin stimulates phosphorylation of serine residues in soluble insulin receptors .
19887566	0	serine	103,109	insulin_receptor	74,90	serine	insulin receptor	CHEBI:17822	3643	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Central insulin signaling is attenuated by long-term insulin exposure via insulin_receptor substrate-1 serine phosphorylation , proteasomal degradation , and lysosomal insulin_receptor degradation .
2136851	0	serine	108,114	insulin_receptor	67,83	serine	insulin receptor	CHEBI:17822	3643	Chemical	Gene	kinase|compound|START_ENTITY END_ENTITY|nmod|kinase	Insulin-sensitive phosphorylation of serine 1293/1294 on the human insulin_receptor by a tightly associated serine kinase .
2464505	0	serine	29,35	insulin_receptor	71,87	serine	insulin receptor	CHEBI:17822	3643	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Characterization of sites of serine phosphorylation in human placental insulin_receptor copurified with insulin-stimulated serine kinase activity by two-dimensional thin-layer peptide mapping .
7542920	1	serine	195,201	insulin_receptor	178,194	serine	insulin receptor	CHEBI:17822	3643	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Characterization of synthetic peptide substrates for the insulin-stimulated insulin_receptor serine kinase .
8948451	0	serine	50,56	insulin_receptor	33,49	serine	insulin receptor	CHEBI:17822	3643	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Studies on an insulin-stimulated insulin_receptor serine kinase activity : separation of the kinase activity from the insulin_receptor and its reconstitution back to the insulin_receptor .
15473137	0	serine	38,44	insulin_receptor_substrate-1	64,92	serine	insulin receptor substrate-1	CHEBI:17822	486148(Tax:9615)	Chemical	Gene	START_ENTITY|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Protein_kinase_C -LRB- PKC -RRB- beta modulates serine phosphorylation of insulin_receptor_substrate-1 -LRB- IRS-1 -RRB- -- effect of overexpression of PKCbeta on insulin signal transduction .
15914920	0	serine	75,81	insulin_receptor_substrate-1	101,129	serine	insulin receptor substrate-1	CHEBI:17822	3667	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Disruption of the availability of amino_acids induces a rapid reduction of serine phosphorylation of insulin_receptor_substrate-1 in vivo and in vitro .
16150868	0	serine	99,105	insulin_receptor_substrate-1	67,95	serine	insulin receptor substrate-1	CHEBI:17822	3667	Chemical	Gene	residues|amod|START_ENTITY END_ENTITY|nmod|residues	Interleukin-1alpha inhibits insulin signaling with phosphorylating insulin_receptor_substrate-1 on serine residues in 3T3-L1 adipocytes .
9761740	0	serine	79,85	insulin_receptor_substrate-1	50,78	serine	insulin receptor substrate-1	CHEBI:17822	3667	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Phosphatidylinositol 3 ' - kinase associates with an insulin_receptor_substrate-1 serine kinase distinct from its intrinsic serine kinase .
12714600	0	serine	17,23	insulin_receptor_substrate_1	43,71	serine	insulin receptor substrate 1	CHEBI:17822	3667	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Aspirin inhibits serine phosphorylation of insulin_receptor_substrate_1 in tumor_necrosis_factor-treated cells through targeting multiple serine kinases .
14641015	0	serine	76,82	insulin_receptor_substrate_1	47,75	serine	insulin receptor substrate 1	CHEBI:17822	3667	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Fatty_acid-induced insulin resistance : role of insulin_receptor_substrate_1 serine phosphorylation in the retroregulation of insulin signalling .
15302844	0	serine	39,45	insulin_receptor_substrate_1	10,38	serine	insulin receptor substrate 1	CHEBI:17822	25467(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Increased insulin_receptor_substrate_1 serine phosphorylation and stress-activated protein kinase/c-Jun N-terminal kinase activation associated with vascular insulin resistance in spontaneously hypertensive rats .
15922338	0	serine	17,23	insulin_receptor_substrate_1	43,71	serine	insulin receptor substrate 1	CHEBI:17822	25467(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Aspirin inhibits serine phosphorylation of insulin_receptor_substrate_1 in growth hormone treated animals .
25107476	0	serine	9,15	insulin_receptor_substrate_1	35,63	serine	insulin receptor substrate 1	CHEBI:17822	16367(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Abnormal serine phosphorylation of insulin_receptor_substrate_1 is associated with tau pathology in Alzheimer 's _ disease and tauopathies .
9054461	0	serine	132,138	keratin_8	25,34	serine	keratin 8	CHEBI:17822	3856	Chemical	Gene	START_ENTITY|nsubj|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation of human keratin_8 in vivo at conserved head domain serine 23 and at epidermal_growth_factor-stimulated tail domain serine 431 .
11730816	0	serine	32,38	lipoprotein_lipase	13,31	serine	lipoprotein lipase	CHEBI:17822	4023	Chemical	Gene	START_ENTITY|nsubj|Influence Influence|nmod|END_ENTITY	Influence of lipoprotein_lipase serine 447 stop polymorphism on tracking of triglycerides and HDL cholesterol from childhood to adulthood and familial risk of coronary_artery_disease : the Bogalusa heart study .
17291198	0	serine	28,34	lipoprotein_lipase	4,22	serine	lipoprotein lipase	CHEBI:17822	4023	Chemical	Gene	variant|compound|START_ENTITY variant|amod|END_ENTITY	The lipoprotein_lipase gene serine 447 stop variant influences hypertension-induced left_ventricular_hypertrophy and risk of coronary_heart_disease .
18187430	0	serine	23,29	lipoprotein_lipase	4,22	serine	lipoprotein lipase	CHEBI:17822	4023	Chemical	Gene	polymorphism|compound|START_ENTITY polymorphism|amod|END_ENTITY	The lipoprotein_lipase serine 447 stop polymorphism is associated with altered serum carotenoid concentrations in the Stanislas Family Study .
16307483	0	serine	47,53	lympho-epithelial_Kazal-type_inhibitor	73,111	serine	lympho-epithelial Kazal-type inhibitor	CHEBI:17822	11005	Chemical	Gene	protease|amod|START_ENTITY END_ENTITY|amod|protease	Inhibition of human kallikreins_5_and_7 by the serine protease inhibitor lympho-epithelial_Kazal-type_inhibitor -LRB- LEKTI -RRB- .
12021391	4	serine	939,945	mGluR7	920,926	serine	mGluR7	CHEBI:17822	14807(Tax:10090)	Chemical	Gene	residue|compound|START_ENTITY END_ENTITY|nmod|residue	These actions are mediated by PKC - , PKA - , or PKG-dependent phosphorylation of mGluR7 at a single serine residue , Ser -LRB- 862 -RRB- , in the carboxyl terminus of the receptor .
24801268	0	serine	34,40	maspin	61,67	serine	maspin	CHEBI:17822	5268	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Loss of heterozygosity in mammary serine protease inhibitor -LRB- maspin -RRB- and p53 at chromosome 17 and 18 in oral_cavity_squamous_cell_carcinoma .
24469043	1	serine	170,176	matriptase	187,197	serine	matriptase	CHEBI:17822	19143(Tax:10090)	Chemical	Gene	protease|compound|START_ENTITY protease|appos|END_ENTITY	The membrane-anchored serine protease , matriptase , is consistently dysregulated in a range of human carcinomas , and high matriptase activity correlates with poor prognosis .
20015002	0	serine	26,32	matriptase-2	43,55	serine	matriptase-2	CHEBI:17822	164656	Chemical	Gene	protease|compound|START_ENTITY protease|appos|END_ENTITY	The type II transmembrane serine protease , matriptase-2 : Possible links to cancer ?
1572695	0	serine	76,82	medullasin	62,72	serine	medullasin	CHEBI:17822	1991	Chemical	Gene	protease|amod|START_ENTITY END_ENTITY|dep|protease	Induction of activated killer cells from human lymphocytes by medullasin -LRB- a serine protease in bone marrow cells -RRB- .
1859409	0	serine	66,72	medullasin	52,62	serine	medullasin	CHEBI:17822	1991	Chemical	Gene	protease|amod|START_ENTITY END_ENTITY|dep|protease	The primary structure and elastinolytic activity of medullasin -LRB- a serine protease of bone marrow -RRB- .
12805386	0	serine	27,33	myosin	65,71	serine	myosin	CHEBI:17822	79784	Chemical	Gene	START_ENTITY|nmod|site site|nmod|END_ENTITY	Chemical identification of serine 181 at the ATP-binding site of myosin as a residue esterified selectively by the fluorescent reagent 9-anthroylnitrile .
22120626	0	serine	67,73	myosin	14,20	serine	myosin	CHEBI:17822	395534(Tax:9031)	Chemical	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|efficiently efficiently|amod|END_ENTITY	Smooth muscle myosin light chain kinase efficiently phosphorylates serine 15 of cardiac myosin_regulatory_light_chain .
2966156	0	serine	68,74	myosin	130,136	serine	myosin	CHEBI:17822	79784	Chemical	Gene	START_ENTITY|nmod|properties properties|nmod|END_ENTITY	Effects of phosphorylation of light chain residues threonine 18 and serine 19 on the properties and conformation of smooth muscle myosin .
3145287	0	serine	17,23	myosin	90,96	serine	myosin	CHEBI:17822	79784	Chemical	Gene	residues|compound|START_ENTITY located|nsubjpass|residues located|nmod|tailpiece tailpiece|nmod|END_ENTITY	Phosphorylatable serine residues are located in a non-helical tailpiece of a catch muscle myosin .
8108436	0	serine	45,51	myosin	59,65	serine	myosin	CHEBI:17822	79784	Chemical	Gene	START_ENTITY|nmod|chain chain|amod|END_ENTITY	Charge replacement near the phosphorylatable serine of the myosin regulatory light chain mimics aspects of phosphorylation .
9425160	0	serine	25,31	myosin	50,56	serine	myosin	CHEBI:17822	79784	Chemical	Gene	19|amod|START_ENTITY localization|nmod|19 phosphorylated|nsubj|localization phosphorylated|dobj|II II|compound|END_ENTITY	Specific localization of serine 19 phosphorylated myosin II during cell locomotion and mitosis of cultured cells .
22419107	0	serine	19,25	neural_cell_adhesion_molecule	37,66	serine	neural cell adhesion molecule	CHEBI:17822	4684	Chemical	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of serine 774 of the neural_cell_adhesion_molecule is necessary for cyclic_adenosine_monophosphate response element binding protein activation and neurite outgrowth .
23377853	0	serine	19,25	neural_cell_adhesion_molecule	37,66	serine	neural cell adhesion molecule	CHEBI:17822	4684	Chemical	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of serine 774 of the neural_cell_adhesion_molecule -LRB- NCAM -RRB- is involved in the interaction with collapsin_response_mediator_protein-2 .
11388408	0	serine	36,42	neurosin	53,61	serine	neurosin	CHEBI:17822	5653	Chemical	Gene	protease|compound|START_ENTITY protease|appos|END_ENTITY	Characterization of a brain-related serine protease , neurosin -LRB- human kaillikrein 6 -RRB- , in human cerebrospinal fluid .
9003450	0	serine	42,48	neurosin	59,67	serine	neurosin	CHEBI:17822	5653	Chemical	Gene	protease|compound|START_ENTITY protease|appos|END_ENTITY	Molecular cloning of a novel trypsin-like serine protease -LRB- neurosin -RRB- preferentially expressed in brain .
9971783	0	serine	110,116	nsp4	105,109	serine	nsp4	CHEBI:17822	400668	Chemical	Gene	protease|compound|START_ENTITY protease|amod|END_ENTITY	Proteolytic processing of the open reading frame 1b-encoded part of arterivirus replicase is mediated by nsp4 serine protease and Is essential for virus replication .
10625701	0	serine	94,100	oatp1	120,125	serine	oatp1	CHEBI:17822	50572(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Down-regulation by extracellular ATP of rat hepatocyte organic anion transport is mediated by serine phosphorylation of oatp1 .
17623675	0	serine	25,31	p300	51,55	serine	p300	CHEBI:17822	2033	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	ERK2-mediated C-terminal serine phosphorylation of p300 is vital to the regulation of epidermal growth factor-induced keratin_16 gene expression .
2951248	0	serine	22,28	p36	54,57	serine	p36	CHEBI:17822	302	Chemical	Gene	sites|amod|START_ENTITY sites|nmod|END_ENTITY	Functionally distinct serine phosphorylation sites of p36 , the cellular substrate of retroviral protein kinase ; differential inhibition of reassociation with p11 .
10094408	0	serine	105,111	p53	130,133	serine	p53	CHEBI:17822	301300(Tax:10116)	Chemical	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Protein kinase CK2-dependent regulation of p53 function : evidence that the phosphorylation status of the serine 386 -LRB- CK2 -RRB- site of p53 is constitutive and stable .
10425175	0	serine	44,50	p53	21,24	serine	p53	CHEBI:17822	7157	Chemical	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Inhibition of mutant p53 phosphorylation at serine 15 or serine 315 partially restores the function of wild-type p53 .
10446957	0	serine	32,38	p53	28,31	serine	p53	CHEBI:17822	7157	Chemical	Gene	START_ENTITY|nsubj|phosphorylation phosphorylation|nmod|END_ENTITY	Enhanced phosphorylation of p53 serine 18 following DNA damage in DNA-dependent_protein_kinase catalytic subunit-deficient cells .
11239457	0	serine	25,31	p53	21,24	serine	p53	CHEBI:17822	7157	Chemical	Gene	complex|compound|START_ENTITY complex|compound|END_ENTITY	A DNA damage-induced p53 serine 392 kinase complex contains CK2 , hSpt16 , and SSRP1 .
11258898	0	serine	25,31	p53	51,54	serine	p53	CHEBI:17822	7157	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Thyroid_hormone promotes serine phosphorylation of p53 by mitogen-activated protein kinase .
11526498	0	serine	96,102	p53	115,118	serine	p53	CHEBI:17822	7157	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	Activation of p53 transcriptional activity requires ATM 's kinase domain and multiple N-terminal serine residues of p53 .
12131363	0	serine	20,26	p53	46,49	serine	p53	CHEBI:17822	7157	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Resveratrol induced serine phosphorylation of p53 causes apoptosis in a mutant p53 prostate_cancer cell line .
16082226	0	serine	30,36	p53	66,69	serine	p53	CHEBI:17822	7157	Chemical	Gene	START_ENTITY|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Blockage of NF-kappaB induces serine 15 phosphorylation of mutant p53 by JNK kinase in prostate_cancer cells .
16247456	0	serine	10,16	p53	39,42	serine	p53	CHEBI:17822	7157	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Defect in serine 46 phosphorylation of p53 contributes to acquisition of p53 resistance in oral_squamous_cell_carcinoma cells .
16538517	0	serine	74,80	p53	29,32	serine	p53	CHEBI:17822	7157	Chemical	Gene	mutation|nmod|START_ENTITY mutation|compound|END_ENTITY	Lack of prognostic impact of p53 gene mutation and p53 phosphorylation at serine 15 in multimodally treated adenocarcinomas of the gastroesophageal junction .
16552184	0	serine	27,33	p53	20,23	serine	p53	CHEBI:17822	7157	Chemical	Gene	residues|amod|START_ENTITY END_ENTITY|nmod|residues	CDK9 phosphorylates p53 on serine residues 33 , 315 and 392 .
19882354	0	serine	109,115	p53	105,108	serine	p53	CHEBI:17822	7157	Chemical	Gene	residues|compound|START_ENTITY residues|compound|END_ENTITY	Inhibitory role of cAMP on doxorubicin-induced apoptosis in pre-B ALL cells through dephosphorylation of p53 serine residues .
20145032	0	serine	23,29	p53	19,22	serine	p53	CHEBI:17822	22060(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation of p53 serine 18 upregulates apoptosis to suppress Myc-induced tumorigenesis .
20673369	5	serine	687,693	p53	706,709	serine	p53	CHEBI:17822	7157	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	Phosphorylation at specific serine residues in p53 is essential for it to cause cell growth inhibition .
21394211	0	serine	12,18	p53	25,28	serine	p53	CHEBI:17822	7157	Chemical	Gene	START_ENTITY|nmod|regulation regulation|compound|END_ENTITY	Role of p53 serine 46 in p53 target gene regulation .
21394211	0	serine	12,18	p53	8,11	serine	p53	CHEBI:17822	7157	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of p53 serine 46 in p53 target gene regulation .
21539808	0	serine	194,200	p53	223,226	serine	p53	CHEBI:17822	7157	Chemical	Gene	START_ENTITY|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	In the absence of cellular poly _ -LRB- A -RRB- _ binding_protein , the glycolytic enzyme GAPDH translocated to the cell nucleus and activated the GAPDH mediated apoptotic pathway by enhancing acetylation and serine 46 phosphorylation of p53 .
7936649	0	serine	21,27	p53	62,65	serine	p53	CHEBI:17822	7157	Chemical	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	The carboxy-terminal serine 392 phosphorylation site of human p53 is not required for wild-type activities .
8502477	0	serine	16,22	p53	56,59	serine	p53	CHEBI:17822	7157	Chemical	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Mutation of the serine 15 phosphorylation site of human p53 reduces the ability of p53 to inhibit cell cycle progression .
9830059	0	serine	23,29	p53	19,22	serine	p53	CHEBI:17822	7157	Chemical	Gene	START_ENTITY|nsubj|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation of p53 serine 15 increases interaction with CBP .
12711606	0	serine	95,101	p65	121,124	serine	p65	CHEBI:17822	5970	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Hydrogen_peroxide activates NF-kappa_B through tyrosine phosphorylation of I_kappa_B_alpha and serine phosphorylation of p65 : evidence for the involvement of I_kappa_B_alpha kinase and Syk protein-tyrosine kinase .
19038492	0	serine	75,81	p65_subunit_of_NF-kappaB	109,133	serine	p65 subunit of NF-kappaB	CHEBI:17822	5970	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Identification of genes , including the gene encoding p27Kip1 , regulated by serine 276 phosphorylation of the p65_subunit_of_NF-kappaB .
19910110	0	serine	48,54	p65_subunit_of_NF-kappaB	82,106	serine	p65 subunit of NF-kappaB	CHEBI:17822	5970	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Identification of a small molecule inhibitor of serine 276 phosphorylation of the p65_subunit_of_NF-kappaB using in silico molecular docking .
1409678	2	serine	356,362	p68	373,376	serine	p68	CHEBI:17822	20218(Tax:10090)	Chemical	Gene	protease|compound|START_ENTITY protease|appos|END_ENTITY	The sensitivity of a merozoite-specific serine protease -LRB- p68 -RRB- to various inhibitors and the effect of these inhibitors on invasion indicate a crucial role for p68 .
16873706	0	serine	44,50	p85alpha	127,135	serine	p85alpha	CHEBI:17822	5295	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Molecular mechanisms of insulin resistance : serine phosphorylation of insulin_receptor_substrate-1 and increased expression of p85alpha : the two sides of a coin .
10581004	0	serine	51,57	paxillin	20,28	serine	paxillin	CHEBI:17822	360820(Tax:10116)	Chemical	Gene	kinases|compound|START_ENTITY kinases|amod|END_ENTITY	Characterization of paxillin LIM domain-associated serine threonine kinases : activation by angiotensin_II in vascular smooth muscle cells .
12198769	0	serine	37,43	paxillin	76,84	serine	paxillin	CHEBI:17822	5829	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Protein phosphatase-2A modulates the serine and tyrosine phosphorylation of paxillin in Lewis_lung_carcinoma tumor variants .
12837288	0	serine	12,18	paxillin	65,73	serine	paxillin	CHEBI:17822	5829	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Ras-induced serine phosphorylation of the focal adhesion protein paxillin is mediated by the Raf -- > MEK -- > ERK pathway .
8631923	0	serine	34,40	paxillin	60,68	serine	paxillin	CHEBI:17822	5829	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Integrin alpha v beta_5-dependent serine phosphorylation of paxillin in cultured human macrophages adherent to vitronectin .
1828897	0	serine	69,75	phospholipase_C-gamma_1	42,65	serine	phospholipase C-gamma 1	CHEBI:17822	5335	Chemical	Gene	residues|amod|START_ENTITY END_ENTITY|nmod|residues	CD3 stimulation causes phosphorylation of phospholipase_C-gamma_1 on serine and tyrosine residues in a human T-cell line .
12530668	0	serine	76,82	pro-opiomelanocortin	55,75	serine	pro-opiomelanocortin	CHEBI:17822	5443	Chemical	Gene	protease|compound|START_ENTITY protease|amod|END_ENTITY	Adrenal growth is controlled by expression of specific pro-opiomelanocortin serine protease in the outer adrenal cortex .
11433419	0	serine	29,35	prostasin	19,28	serine	prostasin	CHEBI:17822	5652	Chemical	Gene	protease|compound|START_ENTITY protease|amod|END_ENTITY	Down-regulation of prostasin serine protease : a potential invasion suppressor in prostate_cancer .
26715240	0	serine	71,77	prostasin	88,97	serine	prostasin	CHEBI:17822	5652	Chemical	Gene	proteases|compound|START_ENTITY proteases|amod|END_ENTITY	Ibuprofen regulates the expression and function of membrane-associated serine proteases prostasin and matriptase .
1702714	0	serine	85,91	prostate-specific_antigen	22,47	serine	prostate-specific antigen	CHEBI:17822	354	Chemical	Gene	START_ENTITY|nsubj|activity activity|nmod|END_ENTITY	Enzymatic activity of prostate-specific_antigen and its reactions with extracellular serine proteinase inhibitors .
7846074	0	serine	2,8	protease_nexin_I	29,45	serine	protease nexin I	CHEBI:17822	5270	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	A serine protease inhibitor , protease_nexin_I , rescues motoneurons from naturally occurring and axotomy-induced cell death .
10231023	0	serine	57,63	protein_C	83,92	serine	protein C	CHEBI:17822	5624	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	A molecular model of a point mutation -LRB- Val297Met -RRB- in the serine protease domain of protein_C .
11108839	0	serine	78,84	protein_kinase_B	93,109	serine	protein kinase B	CHEBI:17822	2185	Chemical	Gene	kinases|compound|START_ENTITY kinases|amod|END_ENTITY	The T cell antigen receptor activates phosphatidylinositol 3-kinase-regulated serine kinases protein_kinase_B and ribosomal_S6_kinase_1 .
11943586	0	serine	21,27	proteinase	28,38	serine	proteinase	CHEBI:17822	100616101	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	LEKTI : a multidomain serine proteinase inhibitor with pathophysiological relevance .
1368969	0	serine	75,81	proteinase	8,18	serine	proteinase	CHEBI:17822	100616101	Chemical	Gene	proteinases|amod|START_ENTITY characterization|nmod|proteinases tools|nmod|characterization inhibitors|dep|tools inhibitors|compound|END_ENTITY	Labeled proteinase inhibitors : versatile tools for the characterization of serine proteinases in solid-phase assays .
2729962	0	serine	28,34	proteinase	35,45	serine	proteinase	CHEBI:17822	100616101	Chemical	Gene	Mechanism|nmod|START_ENTITY END_ENTITY|nsubj|Mechanism	Mechanism of staphylococcal serine proteinase inactivation by lymphocytes and granulocytes .
2747551	0	serine	11,17	proteinase	18,28	serine	proteinase	CHEBI:17822	100616101	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of serine proteinase from Staphylococcus_aureus V8 cells on Con A stimulation of human lymphocytes .
2760036	0	serine	88,94	proteinase	95,105	serine	proteinase	CHEBI:17822	12393251	Chemical	Gene	procaryotic|appos|START_ENTITY gene|nmod|procaryotic structure|nmod|gene END_ENTITY|nsubj|structure	Primary structure and organization of the gene for a procaryotic , cell envelope-located serine proteinase .
8368519	0	serine	30,36	proteinase	37,47	serine	proteinase	CHEBI:17822	100616101	Chemical	Gene	determination|nmod|START_ENTITY END_ENTITY|nsubj|determination	Quantitative determination of serine proteinase inhibitor activity using a radial diffusion assay .
8757293	0	serine	43,49	proteinase	50,60	serine	proteinase	CHEBI:17822	100616101	Chemical	Gene	antigen|amod|START_ENTITY antigen|compound|END_ENTITY	The crystal structure of PR3 , a neutrophil serine proteinase antigen of Wegener 's _ granulomatosis antibodies .
9011247	0	serine	29,35	proteinase	36,46	serine	proteinase	CHEBI:17822	100616101	Chemical	Gene	PC|amod|START_ENTITY PC|compound|END_ENTITY	-LSB- Isolation and properties of serine proteinase PC from the Kamchatka crab , Paralithodes camtschatica -- a proteolytic enzyme with broad specificity -RSB- .
16580636	0	serine	10,16	serotonin_transporter	29,50	serine	serotonin transporter	CHEBI:17822	693007(Tax:7091)	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	Conserved serine residues in serotonin_transporter contribute to high-affinity cocaine binding .
10570951	0	serine	22,28	serpin_C1	57,66	serine	serpin C1	CHEBI:17822	462	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|amod|END_ENTITY	Hepatitis_C virus NS3 serine protease interacts with the serpin_C1 inhibitor .
17408967	0	serine	43,49	sfp2	64,68	serine	sfp2	CHEBI:17822	852597(Tax:4932)	Chemical	Gene	expression|nmod|START_ENTITY protease|nsubj|expression protease|dobj|END_ENTITY	Functional expression of the keratinolytic serine protease gene sfp2 from Streptomyces fradiae var .
8383357	0	serine	18,24	synaptophysin	44,57	serine	synaptophysin	CHEBI:17822	24804(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Calcium-dependent serine phosphorylation of synaptophysin .
1526985	0	serine	101,107	thioesterase_II	142,157	serine	thioesterase II	CHEBI:17822	10005	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Utilization of an active serine_101 -- cysteine mutant to demonstrate the proximity of the catalytic serine 101 and histidine_237 residues in thioesterase_II .
8104935	0	serine	27,33	thrombin	41,49	serine	thrombin	CHEBI:17822	2147	Chemical	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	Substituting isoserine for serine in the thrombin receptor activation peptide SFLLRN confers resistance to aminopeptidase_M-induced cleavage and inactivation .
11278496	0	serine	61,67	transcription_factor_IIA	33,57	serine	transcription factor IIA	CHEBI:17822	2957	Chemical	Gene	residues|amod|START_ENTITY END_ENTITY|nmod|residues	Taf -LRB- II -RRB- _ 250 phosphorylates human transcription_factor_IIA on serine residues important for TBP binding and transcription activity .
2124349	0	serine	22,28	tyrosinase	41,51	serine	tyrosinase	CHEBI:17822	22173(Tax:10090)	Chemical	Gene	mutation|amod|START_ENTITY mutation|nmod|END_ENTITY	Conserved cysteine to serine mutation in tyrosinase is responsible for the classical albino mutation in laboratory mice .
1973163	0	serine	51,57	tyrosine_hydroxylase	19,39	serine	tyrosine hydroxylase	CHEBI:17822	25085(Tax:10116)	Chemical	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of tyrosine_hydroxylase in situ at serine 8 , 19 , 31 , and 40 .
1377417	0	serine	125,131	u-PA	151,155	serine	u-PA	CHEBI:17822	5328	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	An enzyme-linked immunosorbent assay for urokinase-type_plasminogen_activator -LRB- u-PA -RRB- and mutants and chimeras containing the serine protease domain of u-PA .
20418543	0	serine207	10,19	troponin_T	39,49	serine207	troponin T	null	7138	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Decreased serine207 phosphorylation of troponin_T as a biomarker for left_ventricular_remodelling after myocardial_infarction .
19798690	0	serine239	24,33	VASP	0,4	serine239	VASP	null	7408	Chemical	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	VASP phosphorylation at serine239 regulates the effects of NO on smooth_muscle_cell invasion and contraction of collagen .
12027456	0	serines	38,45	beta-catenin	67,79	serines	beta-catenin	null	1499	Chemical	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of two novel regulated serines in the N terminus of beta-catenin .
1496128	0	serotonin	43,52	5-HT-1c	53,60	serotonin	5-HT-1c	MESH:D012701	25187(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|receptors receptors|amod|END_ENTITY	Chronic clozapine treatment down-regulates serotonin 5-HT-1c receptors in rat brain .
3139864	0	serotonin	44,53	5-HT-1c	54,61	serotonin	5-HT-1c	MESH:D012701	25187(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Putative selective 5-HT-2 antagonists block serotonin 5-HT-1c receptors in the choroid plexus .
10084155	0	serotonin	103,112	5-HT1A	96,102	serotonin	5-HT1A	MESH:D012701	3350	Chemical	Gene	START_ENTITY|amod|affinity affinity|nmod|END_ENTITY	Synthesis of 3-aryl-1 - -LSB- -LRB- 4-phenyl-1-piperazinyl -RRB- butyl -RSB- indazole derivatives and their affinity to 5-HT1A serotonin and dopamine D1 receptors .
10349831	0	serotonin	65,74	5-HT1A	75,81	serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|gene gene|nummod|END_ENTITY	TATA-driven transcriptional initiation and regulation of the rat serotonin 5-HT1A receptor gene .
10660896	0	serotonin	85,94	5-HT1A	32,38	serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY localization|nmod|receptors localization|nmod|END_ENTITY	Somatodendritic localization of 5-HT1A and preterminal axonal localization of 5-HT1B serotonin receptors in adult rat brain .
10800921	0	serotonin	50,59	5-HT1A	33,39	serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|p-chloroamphetamine p-chloroamphetamine|nmod|END_ENTITY	Effect of p-chloroamphetamine on 5-HT1A and 5-HT7 serotonin receptor expression in rat brain .
11027920	0	serotonin	36,45	5-HT1A	29,35	serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|nummod|END_ENTITY	WAY_100135 , an antagonist of 5-HT1A serotonin receptors , attenuates psychotomimetic effects of MK-801 .
11231049	0	serotonin	103,112	5-HT1A	96,102	serotonin	5-HT1A	MESH:D012701	3350	Chemical	Gene	receptors|compound|START_ENTITY receptors|nummod|END_ENTITY	New 3 - -LSB- 4 - -LRB- aryl -RRB- piperazin-1-yl -RSB- -1 - -LRB- benzo -LSB- b -RSB- thiophen-3-yl -RRB- propane derivatives with dual action at 5-HT1A serotonin receptors and serotonin_transporter as a new class of antidepressants .
11330332	0	serotonin	72,81	5-HT1A	82,88	serotonin	5-HT1A	MESH:D012701	3350	Chemical	Gene	START_ENTITY|dep|receptors receptors|nummod|END_ENTITY	Pindolol antagonises G-protein activation at both pre - and postsynaptic serotonin 5-HT1A receptors : a .
11418278	0	serotonin	61,70	5-HT1A	21,27	serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	synthesis|compound|START_ENTITY antagonists|nmod|synthesis antagonists|amod|END_ENTITY	Effects of selective 5-HT1A receptor antagonists on regional serotonin synthesis in the rat brain : an autoradiographic study with alpha - -LSB- 14C -RSB- methyl-L-tryptophan .
11462981	0	serotonin	83,92	5-HT1A	76,82	serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|nummod|END_ENTITY	New 1-aryl-3 - -LRB- 4-arylpiperazin-1-yl -RRB- propane derivatives , with dual action at 5-HT1A serotonin receptors and serotonin_transporter , as a new class of antidepressants .
11483665	0	serotonin	31,40	5-HT1A	69,75	serotonin	5-HT1A	MESH:D012701	15550(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY density|nmod|transporter changes|nmod|density changes|nmod|brain brain|nmod|END_ENTITY	Regional changes in density of serotonin transporter in the brain of 5-HT1A and 5-HT1B knockout mice , and of serotonin innervation in the 5-HT1B knockout .
11989622	0	serotonin	40,49	5-HT1A	22,28	serotonin	5-HT1A	MESH:D012701	3350	Chemical	Gene	START_ENTITY|nsubj|Molecular_dynamics Molecular_dynamics|nmod|END_ENTITY	Molecular_dynamics of 5-HT1A and 5-HT2A serotonin receptors with methylated_buspirone analogues .
11989808	0	serotonin	50,59	5-HT1A	83,89	serotonin	5-HT1A	MESH:D012701	3350	Chemical	Gene	ligands|compound|START_ENTITY piperazines|appos|ligands Interaction|nmod|piperazines Interaction|nmod|receptors receptors|compound|END_ENTITY	Interaction of 1,2,4-substituted _ piperazines , new serotonin receptor ligands , with 5-HT1A and 5-HT2A receptors .
12020683	0	serotonin	42,51	5-HT1A	93,99	serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	VN2222|appos|START_ENTITY activity|nmod|VN2222 reuptake|nsubj|activity reuptake|nmod|receptors receptors|nummod|END_ENTITY	Antidepressant-like activity of VN2222 , a serotonin reuptake inhibitor with high affinity at 5-HT1A receptors .
12404340	0	serotonin	31,40	5-HT1A	0,6	serotonin	5-HT1A	MESH:D012701	3350	Chemical	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	5-HT1A and beyond : the role of serotonin and its receptors in depression and the antidepressant response .
12564641	0	serotonin	38,47	5-HT1A	91,97	serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	efflux|nmod|START_ENTITY clozapine|nmod|efflux Effects|nmod|clozapine Effects|dep|role role|nmod|receptors receptors|nummod|END_ENTITY	Effects of clozapine on the efflux of serotonin and dopamine in the rat brain : the role of 5-HT1A receptors .
12960198	0	serotonin	24,33	5-HT1A	54,60	serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	level|compound|START_ENTITY increases|nsubj|level increases|xcomp|binding binding|nsubj|18F-MPPF 18F-MPPF|nummod|END_ENTITY	A reduced extracellular serotonin level increases the 5-HT1A PET ligand 18F-MPPF binding in the rat hippocampus .
1356248	0	serotonin	50,59	5-HT1A	60,66	serotonin	5-HT1A	MESH:D012701	3350	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nummod|END_ENTITY	The effects of pertussis toxin on dopamine D2 and serotonin 5-HT1A autoreceptor-mediated inhibition of neurotransmitter synthesis : relationship to receptor reserve .
14614949	0	serotonin	20,29	5-HT1A	30,36	serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	agonism|compound|START_ENTITY agonism|nummod|END_ENTITY	Contribution of the serotonin 5-HT1A receptor agonism of 8-OH-DPAT and EMD_128130 to the regulation of haloperidol-induced muscle_rigidity in rats .
14730096	0	serotonin	46,55	5-HT1A	32,38	serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	activity|compound|START_ENTITY vivo|dep|activity vivo|nummod|END_ENTITY	Synthesis , in vitro and in vivo 5-HT1A / 5-HT2A serotonin receptor activity of new hybrid 1,2,3,4-tetrahydro-gamma-carbolines with 1 - -LRB- 2-methoxyphenyl -RRB- piperazine moiety .
15036582	0	serotonin	15,24	5-HT1A	134,140	serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	inhibitor|amod|START_ENTITY Milnacipran|appos|inhibitor suppresses|nsubj|Milnacipran suppresses|nmod|field field|nmod|receptors receptors|nummod|END_ENTITY	Milnacipran , a serotonin and noradrenaline reuptake inhibitor , suppresses long-term potentiation in the rat hippocampal CA1 field via 5-HT1A receptors and alpha 1-adrenoceptors .
15219613	0	serotonin	24,33	5-HT1A	34,40	serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	internalization|compound|START_ENTITY internalization|nummod|END_ENTITY	Toward brain imaging of serotonin 5-HT1A autoreceptor internalization .
15893579	0	serotonin	2,11	5-HT1A	12,18	serotonin	5-HT1A	MESH:D012701	3350	Chemical	Gene	agonist|compound|START_ENTITY agonist|nummod|END_ENTITY	A serotonin 5-HT1A receptor agonist prevents behavioral sensitization to L-DOPA in a rodent model of Parkinson 's _ disease .
16180022	0	serotonin	83,92	5-HT1A	93,99	serotonin	5-HT1A	MESH:D012701	3350	Chemical	Gene	sites|compound|START_ENTITY sites|compound|END_ENTITY	The macaque inferior parietal lobule : cytoarchitecture and distribution pattern of serotonin 5-HT1A binding sites .
16310183	0	serotonin	87,96	5-HT1A	0,6	serotonin	5-HT1A	MESH:D012701	3350	Chemical	Gene	hypothesis|amod|START_ENTITY challenge|nmod|hypothesis agonists|dep|challenge agonists|compound|END_ENTITY	5-HT1A and 5-HT1B receptor agonists and aggression : a pharmacological challenge of the serotonin deficiency hypothesis .
16406667	0	serotonin	73,82	5-HT1A	0,6	serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	neurons|compound|START_ENTITY induced|nmod|neurons immunoreactivity|acl|induced counteracts|dobj|immunoreactivity counteracts|nsubj|activation activation|nummod|END_ENTITY	5-HT1A receptor activation counteracts c-Fos immunoreactivity induced in serotonin neurons of the raphe nuclei after immobilization stress in the male rat .
16421514	0	serotonin	99,108	5-HT1A	109,115	serotonin	5-HT1A	MESH:D012701	3350	Chemical	Gene	activation|compound|START_ENTITY activation|nummod|END_ENTITY	Actions of novel antipsychotic agents on apomorphine-induced PPI disruption : influence of combined serotonin 5-HT1A receptor activation and dopamine D2 receptor blockade .
16685258	0	serotonin	15,24	5-HT1A	25,31	serotonin	5-HT1A	MESH:D012701	3350	Chemical	Gene	binding|compound|START_ENTITY binding|nummod|END_ENTITY	Measurement of serotonin 5-HT1A receptor binding using positron emission tomography and -LSB- carbonyl - -LRB- 11 -RRB- C -RSB- WAY-100635-considerations on the validity of cerebellum as a reference region .
16796994	0	serotonin	42,51	5-HT1A	52,58	serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|nummod|END_ENTITY	Stereoselectivity of 8-OH-DPAT toward the serotonin 5-HT1A receptor : biochemical and molecular modeling study .
16929962	0	serotonin	57,66	5-HT1A	50,56	serotonin	5-HT1A	MESH:D012701	15550(Tax:10090)	Chemical	Gene	receptors|amod|START_ENTITY receptors|nummod|END_ENTITY	Effect of imipramine on the behavior and cerebral 5-HT1A serotonin receptors in mice genetically predisposed to catalepsy .
17003106	0	serotonin	61,70	5-HT1A	43,49	serotonin	5-HT1A	MESH:D012701	3350	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Role of the C-terminal di-leucine motif of 5-HT1A and 5-HT1B serotonin receptors in plasma membrane targeting .
17015907	0	serotonin	45,54	5-HT1A	55,61	serotonin	5-HT1A	MESH:D012701	3350	Chemical	Gene	START_ENTITY|dobj|radioligand radioligand|nummod|END_ENTITY	Synthesis and biologic evaluation of a novel serotonin 5-HT1A receptor radioligand , 18F-labeled mefway , in rodents and imaging by PET in a nonhuman primate .
17984160	0	serotonin	110,119	5-HT1A	182,188	serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY inhibitors|nmod|levels administration|nmod|inhibitors effects|nmod|administration effects|dep|role role|nmod|receptors receptors|nummod|END_ENTITY	Reciprocal effects of combined administration of serotonin , noradrenaline and dopamine reuptake inhibitors on serotonin and dopamine levels in the rat prefrontal cortex : the role of 5-HT1A receptors .
17984160	0	serotonin	49,58	5-HT1A	182,188	serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	noradrenaline|compound|START_ENTITY inhibitors|compound|noradrenaline administration|nmod|inhibitors effects|nmod|administration effects|dep|role role|nmod|receptors receptors|nummod|END_ENTITY	Reciprocal effects of combined administration of serotonin , noradrenaline and dopamine reuptake inhibitors on serotonin and dopamine levels in the rat prefrontal cortex : the role of 5-HT1A receptors .
1824956	0	serotonin	12,21	5-HT1A	22,28	serotonin	5-HT1A	MESH:D012701	3350	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Increase in serotonin 5-HT1A receptors in prefrontal and temporal cortices of brains from patients with chronic schizophrenia .
1831889	0	serotonin	61,70	5-HT1A	71,77	serotonin	5-HT1A	MESH:D012701	3350	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Fetal human brain exhibits a prenatal peak in the density of serotonin 5-HT1A receptors .
1848278	0	serotonin	63,72	5-HT1A	73,79	serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Potential mechanisms involved in the negative coupling between serotonin 5-HT1A receptors and carbachol-stimulated phosphoinositide turnover in the rat hippocampus .
21070242	0	serotonin	32,41	5-HT1A	63,69	serotonin	5-HT1A	MESH:D012701	15550(Tax:10090)	Chemical	Gene	Density|nmod|START_ENTITY transporters|nsubj|Density transporters|dobj|END_ENTITY	Density and function of central serotonin -LRB- 5-HT -RRB- transporters , 5-HT1A and 5-HT2A receptors , and effects of their targeting on BTBR T + tf/J mouse social behavior .
21780177	0	serotonin	61,70	5-HT1A	54,60	serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	agonist|compound|START_ENTITY agonist|nummod|END_ENTITY	Improving voiding efficiency in the diabetic rat by a 5-HT1A serotonin receptor agonist .
22357950	0	serotonin	22,31	5-HT1A	42,48	serotonin	5-HT1A	MESH:D012701	3350	Chemical	Gene	START_ENTITY|amod|receptors receptors|dep|END_ENTITY	Heterodimerization of serotonin receptors 5-HT1A and 5-HT7 differentially regulates receptor signalling and trafficking .
22373544	0	serotonin	92,101	5-HT1A	111,117	serotonin	5-HT1A	MESH:D012701	3350	Chemical	Gene	receptor|compound|START_ENTITY receptor|nummod|END_ENTITY	3D-QSAR study indicates an enhancing effect of membrane ions on psychiatric drugs targeting serotonin receptor 5-HT1A .
22493371	0	serotonin	14,23	5-HT1A	34,40	serotonin	5-HT1A	MESH:D012701	3350	Chemical	Gene	Expression|nmod|START_ENTITY Expression|amod|receptors receptors|dep|END_ENTITY	Expression of serotonin receptors 5-HT1A , 5-HT1B , 5-HT2B and 5-HT4 in ovary and in ovarian_tumours .
24949809	0	serotonin	13,22	5-HT1A	99,105	serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY role|dep|Involvement Involvement|nmod|END_ENTITY	Dual role of serotonin in the acquisition and extinction of reward-driven learning : Involvement of 5-HT1A , 5-HT2A and 5-HT3 receptors .
24955866	0	serotonin	60,69	5-HT1A	70,76	serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	agonist|amod|START_ENTITY agonist|amod|END_ENTITY	-LRB- 6aR -RRB- -11 - amino-N-propyl-noraporphine , a new dopamine D2 and serotonin 5-HT1A dual agonist , elicits potent antiparkinsonian action and attenuates levodopa-induced_dyskinesia in a 6-OHDA-lesioned rat model of Parkinson 's _ disease .
2521252	0	serotonin	60,69	5-HT1A	53,59	serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	sites|amod|START_ENTITY sites|nummod|END_ENTITY	2 - -LRB- Alkylamino -RRB- tetralin derivatives : interaction with 5-HT1A serotonin binding sites .
2529352	0	serotonin	32,41	5-HT1A	42,48	serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|nummod|END_ENTITY	Chromatographic analyses of the serotonin 5-HT1A receptor solubilized from the rat hippocampus .
2532054	0	serotonin	33,42	5-HT1A	26,32	serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|nummod|END_ENTITY	Regional changes in brain 5-HT1A serotonin receptors in the rat model of persistent spasmodic dyskinesias induced by iminodipropionitrile .
26171224	0	serotonin	18,27	5-HT1A	52,58	serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	inhibitor|compound|START_ENTITY inhibitor|nmod|activity activity|nummod|END_ENTITY	DSP-1053 , a novel serotonin reuptake inhibitor with 5-HT1A partial agonistic activity , displays fast antidepressant effect with minimal undesirable effects in juvenile rats .
26973100	0	serotonin	69,78	5-HT1A	62,68	serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|nummod|END_ENTITY	Differential effects of amyloid-beta 1-40 and 1-42 fibrils on 5-HT1A serotonin receptors in rat brain .
2754715	0	serotonin	88,97	5-HT1A	81,87	serotonin	5-HT1A	MESH:D012701	3350	Chemical	Gene	sites|amod|START_ENTITY sites|nummod|END_ENTITY	N - -LRB- phthalimidoalkyl -RRB- derivatives of serotonergic agents : a common interaction at 5-HT1A serotonin binding sites ?
2867462	0	serotonin	29,38	5-HT1A	22,28	serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	subtype|compound|START_ENTITY subtype|nummod|END_ENTITY	-LSB- 3H -RSB- WB4101 labels the 5-HT1A serotonin receptor subtype in rat brain .
2881318	0	serotonin	146,155	5-HT1A	156,162	serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	The interoceptive discriminative stimuli induced by the novel putative anxiolytic TVX_Q_7821 : behavioral evidence for the specific involvement of serotonin 5-HT1A receptors .
2934545	0	serotonin	26,35	5-HT1A	104,110	serotonin	5-HT1A	MESH:D012701	3350	Chemical	Gene	agonists|compound|START_ENTITY constants|nmod|agonists correlate|nsubj|constants correlate|xcomp|Ki Ki|nmod|site site|nummod|END_ENTITY	Dissociation constants of serotonin agonists in the canine basilar artery correlate to Ki values at the 5-HT1A binding site .
2952898	0	serotonin	24,33	5-HT1A	35,41	serotonin	5-HT1A	MESH:D012701	3350	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|END_ENTITY	Differential effects of serotonin -LRB- 5-HT1A and 5-HT2 -RRB- agonists and antagonists on renin and corticosterone secretion .
7494385	0	serotonin	99,108	5-HT1A	12,18	serotonin	5-HT1A	MESH:D012701	15550(Tax:10090)	Chemical	Gene	inhibitor|compound|START_ENTITY fluvoxamine|appos|inhibitor effect|nmod|fluvoxamine mediates|dobj|effect mediates|nsubj|- -|nummod|END_ENTITY	Neither the 5-HT1A - nor the 5-HT2-receptor subtype mediates the effect of fluvoxamine , a selective serotonin reuptake inhibitor , on forced-swimming-induced immobility in mice .
7545820	0	serotonin	83,92	5-HT1A	40,46	serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|agonist agonist|amod|END_ENTITY	Gender and estrous cycle effects of the 5-HT1A agonist , 8-OH-DPAT , on hypothalamic serotonin .
7686633	0	serotonin	62,71	5-HT1A	72,78	serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	-LRB- - -RRB- Tertatolol is a potent antagonist at pre - and postsynaptic serotonin 5-HT1A receptors in the rat brain .
7905292	0	serotonin	72,81	5-HT1A	0,6	serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	agonists|compound|START_ENTITY induced|nmod|agonists erections|acl|induced increases|dobj|erections increases|nsubj|blockade blockade|nummod|END_ENTITY	5-HT1A receptor blockade increases penile erections induced by indirect serotonin agonists .
7932553	1	serotonin	98,107	5-HT1A	108,114	serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|agonists agonists|nummod|END_ENTITY	Derivatives as potent and orally active serotonin 5-HT1A receptor agonists .
7988650	0	serotonin	89,98	5-HT1A	127,133	serotonin	5-HT1A	MESH:D012701	3350	Chemical	Gene	output|compound|START_ENTITY dose|nmod|output effect|nmod|dose effect|dep|role role|nmod|receptors receptors|amod|END_ENTITY	Chronic treatment with citalopram facilitates the effect of a challenge dose on cortical serotonin output : role of presynaptic 5-HT1A receptors .
7988652	0	serotonin	87,96	5-HT1A	39,45	serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	inhibitors|compound|START_ENTITY action|nmod|inhibitors autoreceptors|nmod|action autoreceptors|nsubj|evidence evidence|nmod|importance importance|nmod|END_ENTITY	Further evidence for the importance of 5-HT1A autoreceptors in the action of selective serotonin reuptake inhibitors .
8014870	0	serotonin	27,36	5-HT1A	87,93	serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY release|nsubj|regulation release|nmod|autoreceptors autoreceptors|nummod|END_ENTITY	Differential regulation of serotonin -LRB- 5-HT -RRB- release in the striatum and hippocampus by 5-HT1A autoreceptors of the dorsal and median raphe nuclei .
8158130	0	serotonin	12,21	5-HT1A	22,28	serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|nummod|END_ENTITY	Hippocampal serotonin 5-HT1A receptor enhances acetylcholine release in conscious rats .
8309982	0	serotonin	55,64	5-HT1A	0,6	serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	system|compound|START_ENTITY effect|nmod|system mediate|dobj|effect mediate|nsubj|receptors receptors|nummod|END_ENTITY	5-HT1A receptors mediate the effect of the bulbospinal serotonin system on spinal dorsal horn nociceptive neurons .
8364729	0	serotonin	113,122	5-HT1A	62,68	serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Stress and antidepressant effects on hippocampal and cortical 5-HT1A and 5-HT2 receptors and transport sites for serotonin .
8374738	0	serotonin	86,95	5-HT1A	33,39	serotonin	5-HT1A	MESH:D012701	407137(Tax:9913)	Chemical	Gene	sites|amod|START_ENTITY labeling|nmod|sites reflect|dobj|labeling reflect|nsubj|differences differences|nmod|binding binding|nummod|END_ENTITY	Apparent regional differences in 5-HT1A binding may reflect -LSB- 3H -RSB- 8-OH-DPAT labeling of serotonin uptake sites .
8566173	0	serotonin	20,29	5-HT1A	80,86	serotonin	5-HT1A	MESH:D012701	3350	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|receptors receptors|compound|END_ENTITY	Mitogenic effect of serotonin in human small_cell_lung_carcinoma cells via both 5-HT1A and 5-HT1D receptors .
8592129	0	serotonin	14,23	5-HT1A	24,30	serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Antagonism of serotonin 5-HT1A receptors potentiates the increases in extracellular monoamines induced by duloxetine in rat hypothalamus .
8611634	0	serotonin	49,58	5-HT1A	59,65	serotonin	5-HT1A	MESH:D012701	3350	Chemical	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Cell-specific regulation of the stably expressed serotonin 5-HT1A receptor and altered ganglioside synthesis .
8726963	0	serotonin	62,71	5-HT1A	120,126	serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	START_ENTITY|xcomp|pindolol pindolol|dep|antagonist antagonist|nmod|receptors receptors|nummod|END_ENTITY	Enhancement of fluoxetine-dependent increase of extracellular serotonin -LRB- 5-HT -RRB- levels by -LRB- - -RRB- - pindolol , an antagonist at 5-HT1A receptors .
8728551	0	serotonin	85,94	5-HT1A	8,14	serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	fluoxetine|nmod|START_ENTITY fluoxetine|nsubj|Role Role|nmod|receptors receptors|nummod|END_ENTITY	Role of 5-HT1A receptors in the effects of acute chronic fluoxetine on extracellular serotonin in the frontal cortex .
8788529	0	serotonin	15,24	5-HT1A	25,31	serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	agonists|compound|START_ENTITY agonists|nummod|END_ENTITY	The anxiolytic serotonin 5-HT1A receptor agonists buspirone , ipsapirone and gepirone are inhibitors of tyrosine hydroxylation in rat striatum .
8878215	0	serotonin	26,35	5-HT1A	36,42	serotonin	5-HT1A	MESH:D012701	100008780(Tax:9986)	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Do beta-adrenoceptors and serotonin 5-HT1A receptors have similar functions in the control of intraocular pressure in the rabbit ?
8945740	0	serotonin	94,103	5-HT1A	62,68	serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	synthesis|compound|START_ENTITY modulating|dobj|synthesis autoreceptors|acl|modulating autoreceptors|nummod|END_ENTITY	The alpha 2-adrenoceptor antagonist idazoxan is an agonist at 5-HT1A autoreceptors modulating serotonin synthesis in the rat brain in vivo .
8982718	0	serotonin	48,57	5-HT1A	0,6	serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	BMY-14802|nmod|START_ENTITY effects|nmod|BMY-14802 effects|nummod|END_ENTITY	5-HT1A receptor agonist effects of BMY-14802 on serotonin release in dorsal raphe and hippocampus .
9048762	0	serotonin	71,80	5-HT1A	156,162	serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	levels|nmod|START_ENTITY increase|nmod|levels Potentiation|nmod|increase Potentiation|nmod|cortex cortex|acl|moving moving|nmod|blockade blockade|nmod|END_ENTITY	Potentiation of the fluoxetine-induced increase in dialysate levels of serotonin -LRB- 5-HT -RRB- in the frontal cortex of freely moving rats by combined blockade of 5-HT1A and 5-HT1B receptors with WAY_100 ,635 and GR 127,935 .
9098681	0	serotonin	13,22	5-HT1A	69,75	serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|nmod|properties properties|nummod|END_ENTITY	EMD_68843 , a serotonin reuptake inhibitor with selective presynaptic 5-HT1A receptor agonistic properties .
9142996	0	serotonin	53,62	5-HT1A	63,69	serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	system|compound|START_ENTITY system|nummod|END_ENTITY	Differential effects of three acute stressors on the serotonin 5-HT1A receptor system in rat brain .
9187317	0	serotonin	102,111	5-HT1A	95,101	serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|nummod|END_ENTITY	Single doses of MK-801 , a non-competitive antagonist of NMDA receptors , increase the number of 5-HT1A serotonin receptors in the rat brain .
9223549	0	serotonin	48,57	5-HT1A	114,120	serotonin	5-HT1A	MESH:D012701	3350	Chemical	Gene	ligand|nmod|START_ENTITY benzodioxopiperazine|dobj|ligand benzodioxopiperazine|dep|receptors receptors|nmod|hD2/hD3 hD2/hD3|amod|END_ENTITY	S_15535 , a novel benzodioxopiperazine ligand of serotonin -LRB- 5-HT -RRB- 1A receptors : I. Interaction with cloned human -LRB- h -RRB- 5-HT1A , dopamine hD2/hD3 and h alpha2A-adrenergic receptors in relation to modulation of cortical monoamine release and activity in models of potential antidepressant activity .
9225266	0	serotonin	54,63	5-HT1A	64,70	serotonin	5-HT1A	MESH:D012701	3350	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Inhibition of cAMP accumulation via recombinant human serotonin 5-HT1A receptors : considerations on receptor effector coupling across systems .
9225271	0	serotonin	86,95	5-HT1A	10,16	serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	increase|nmod|START_ENTITY antagonists|nmod|increase antagonists|nummod|END_ENTITY	Effect of 5-HT1A receptor antagonists on citalopram-induced increase in extracellular serotonin in the frontal cortex , striatum and dorsal hippocampus .
9652362	0	serotonin	66,75	5-HT1A	93,99	serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	synthesis|compound|START_ENTITY antagonism|nmod|synthesis antagonism|nmod|antagonists antagonists|amod|END_ENTITY	Differential regional antagonism of 8-OH-DPAT-induced decrease in serotonin synthesis by two 5-HT1A receptor antagonists .
9670995	0	serotonin	59,68	5-HT1A	69,75	serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	sites|compound|START_ENTITY sites|amod|END_ENTITY	Age-dependent loss of corticosterone modulation of central serotonin 5-HT1A receptor binding sites .
9873746	0	serotonin	127,136	5-HT1A	43,49	serotonin	5-HT1A	MESH:D012701	3350	Chemical	Gene	reuptake|compound|START_ENTITY derivatives|nmod|reuptake coupling|nmod|derivatives antagonists|nmod|coupling antagonists|amod|END_ENTITY	Design and synthesis of new potent , silent 5-HT1A antagonists by covalent coupling of aminopropanol derivatives with selective serotonin reuptake inhibitors .
9886078	0	serotonin	43,52	5-HT1A	53,59	serotonin	5-HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	START_ENTITY|dep|receptors receptors|nummod|END_ENTITY	Differential regulation of somatodendritic serotonin 5-HT1A receptors by 2-week treatments with the selective agonists alnespirone -LRB- S-20499 -RRB- and 8-hydroxy-2 - -LRB- Di-n-propylamino -RRB- tetralin : microdialysis and autoradiographic studies in rat brain .
15009637	0	serotonin	18,27	5-HT1A_receptor	59,74	serotonin	5-HT1A receptor	MESH:D012701	15550(Tax:10090)	Chemical	Gene	efflux|nmod|START_ENTITY raphe|nsubj|efflux raphe|dobj|nucleus nucleus|nmod|mice mice|amod|END_ENTITY	In vivo efflux of serotonin in the dorsal raphe nucleus of 5-HT1A_receptor knockout mice .
15680262	0	serotonin	70,79	5-HT1A_receptor	4,19	serotonin	5-HT1A receptor	MESH:D012701	3350	Chemical	Gene	cocaine|nmod|START_ENTITY effects|nmod|cocaine modulates|dobj|effects modulates|nsubj|END_ENTITY	The 5-HT1A_receptor modulates the effects of cocaine on extracellular serotonin and dopamine levels in the nucleus accumbens .
15758168	0	serotonin	38,47	5-HT1A_receptor	75,90	serotonin	5-HT1A receptor	MESH:D012701	3350	Chemical	Gene	transporter|amod|START_ENTITY variation|nmod|transporter affects|nsubj|variation affects|dobj|END_ENTITY	A functional genetic variation of the serotonin -LRB- 5-HT -RRB- transporter affects 5-HT1A_receptor binding in humans .
16541245	0	serotonin	32,41	5-HT1A_receptor	42,57	serotonin	5-HT1A receptor	MESH:D012701	3350	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Search for correlations between serotonin 5-HT1A_receptor expression and cognitive functions -- a strategy in translational psychopharmacology .
17895527	0	serotonin	42,51	5-HT1A_receptor	63,78	serotonin	5-HT1A receptor	MESH:D012701	15550(Tax:10090)	Chemical	Gene	intracellular|dobj|START_ENTITY intracellular|ccomp|END_ENTITY	13-cis-Retinoic_acid alters intracellular serotonin , increases 5-HT1A_receptor , and serotonin_reuptake_transporter levels in vitro .
17971260	0	serotonin	16,25	5-HT1A_receptor	26,41	serotonin	5-HT1A receptor	MESH:D012701	3350	Chemical	Gene	availability|compound|START_ENTITY availability|amod|END_ENTITY	Decreased brain serotonin 5-HT1A_receptor availability in medication-naive patients with major_depressive_disorder : an in-vivo imaging study using PET and -LSB- carbonyl-11C -RSB- WAY-100635 .
19300037	0	serotonin	45,54	5-HT1A_receptor	55,70	serotonin	5-HT1A receptor	MESH:D012701	3350	Chemical	Gene	piclozotan|amod|START_ENTITY piclozotan|amod|END_ENTITY	Population pharmacokinetics of the selective serotonin 5-HT1A_receptor partial agonist piclozotan .
19800133	0	serotonin	28,37	5-HT1A_receptor	108,123	serotonin	5-HT1A receptor	MESH:D012701	3350	Chemical	Gene	inhibitors|compound|START_ENTITY response|nmod|inhibitors associated|nsubjpass|response associated|nmod|polymorphism polymorphism|amod|END_ENTITY	Early response to selective serotonin reuptake inhibitors in panic_disorder is associated with a functional 5-HT1A_receptor gene polymorphism .
24050112	0	serotonin	4,13	5-HT1A_receptor	14,29	serotonin	5-HT1A receptor	MESH:D012701	3350	Chemical	Gene	agonists|amod|START_ENTITY agonists|amod|END_ENTITY	New serotonin 5-HT1A_receptor agonists endowed with antinociceptive activity in vivo .
26509362	0	serotonin	45,54	5-HT1A_receptor	55,70	serotonin	5-HT1A receptor	MESH:D012701	3350	Chemical	Gene	agent|amod|START_ENTITY agent|amod|END_ENTITY	Comparative assessment of -LRB- 18 -RRB- _ F-Mefway as a serotonin 5-HT1A_receptor PET imaging agent across species - rodents , nonhuman primates , and humans .
9166757	0	serotonin	44,53	5-HT1A_receptor	75,90	serotonin	5-HT1A receptor	MESH:D012701	3350	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|antagonists antagonists|amod|END_ENTITY	Preferential potentiation of the effects of serotonin uptake inhibitors by 5-HT1A_receptor antagonists in the dorsal raphe pathway : role of somatodendritic autoreceptors .
9844013	0	serotonin	54,63	5-HT1A_receptor	64,79	serotonin	5-HT1A receptor	MESH:D012701	15550(Tax:10090)	Chemical	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A_receptor mutant mice .
10208648	0	serotonin	80,89	5-HT1B	90,96	serotonin	5-HT1B	MESH:D012701	3351	Chemical	Gene	receptor|compound|START_ENTITY receptor|nummod|END_ENTITY	Modified ligand binding to the naturally occurring Cys-124 variant of the human serotonin 5-HT1B receptor .
10431754	0	serotonin	69,78	5-HT1B	87,93	serotonin	5-HT1B	MESH:D012701	3351	Chemical	Gene	START_ENTITY|dep|5-HT1A 5-HT1A|nummod|END_ENTITY	Actions of roxindole at recombinant human dopamine D2 , D3 and D4 and serotonin 5-HT1A , 5-HT1B and 5-HT1D receptors .
10465699	0	serotonin	55,64	5-HT1B	0,6	serotonin	5-HT1B	MESH:D012701	25075(Tax:10116)	Chemical	Gene	clearance|nmod|START_ENTITY modulate|dobj|clearance modulate|nsubj|antagonists antagonists|nummod|END_ENTITY	5-HT1B antagonists modulate clearance of extracellular serotonin in rat hippocampus .
10660896	0	serotonin	85,94	5-HT1B	78,84	serotonin	5-HT1B	MESH:D012701	25075(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|nummod|END_ENTITY	Somatodendritic localization of 5-HT1A and preterminal axonal localization of 5-HT1B serotonin receptors in adult rat brain .
11158258	0	serotonin	52,61	5-HT1B	0,6	serotonin	5-HT1B	MESH:D012701	15551(Tax:10090)	Chemical	Gene	inhibitors|amod|START_ENTITY effects|nmod|inhibitors limit|dobj|effects limit|nsubj|Autoreceptors Autoreceptors|compound|END_ENTITY	5-HT1B Autoreceptors limit the effects of selective serotonin re-uptake inhibitors in mouse hippocampus and frontal cortex .
11417564	0	serotonin	68,77	5-HT1B	1,7	serotonin	5-HT1B	MESH:D012701	15551(Tax:10090)	Chemical	Gene	inhibitors|compound|START_ENTITY receptors|nmod|inhibitors receptors|nummod|END_ENTITY	-LSB- 5-HT1B serotonin receptors and antidepressant effects of selective serotonin reuptake inhibitors -RSB- .
11417564	0	serotonin	8,17	5-HT1B	1,7	serotonin	5-HT1B	MESH:D012701	15551(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|nummod|END_ENTITY	-LSB- 5-HT1B serotonin receptors and antidepressant effects of selective serotonin reuptake inhibitors -RSB- .
11483665	0	serotonin	109,118	5-HT1B	138,144	serotonin	5-HT1B	MESH:D012701	15551(Tax:10090)	Chemical	Gene	innervation|compound|START_ENTITY innervation|nmod|knockout knockout|nummod|END_ENTITY	Regional changes in density of serotonin transporter in the brain of 5-HT1A and 5-HT1B knockout mice , and of serotonin innervation in the 5-HT1B knockout .
12383060	0	serotonin	10,19	5-HT1B	21,27	serotonin	5-HT1B	MESH:D012701	3351	Chemical	Gene	START_ENTITY|appos|agonists agonists|nummod|END_ENTITY	Triptans -LRB- serotonin , 5-HT1B / 1D agonists -RRB- in migraine : detailed results and methods of a meta-analysis of 53 trials .
12421573	0	serotonin	41,50	5-HT1B	82,88	serotonin	5-HT1B	MESH:D012701	3351	Chemical	Gene	effects|nmod|START_ENTITY moduline|nsubj|effects moduline|xcomp|antagonist antagonist|nummod|END_ENTITY	The negative immunoregulatory effects of serotonin -LRB- 5-HT -RRB- moduline , an endogenous 5-HT1B receptor antagonist with anti-anxiety properties .
12497617	0	serotonin	28,37	5-HT1B	38,44	serotonin	5-HT1B	MESH:D012701	3351	Chemical	Gene	gene|compound|START_ENTITY gene|nummod|END_ENTITY	Lack of association between serotonin 5-HT1B receptor gene polymorphism and suicidal behavior .
12556913	0	serotonin	4,13	5-HT1B	14,20	serotonin	5-HT1B	MESH:D012701	3351	Chemical	Gene	START_ENTITY|dep|gene gene|nummod|END_ENTITY	The serotonin 5-HT1B receptor gene and attention_deficit_hyperactivity_disorder .
1409786	0	serotonin	55,64	5-HT1B	135,141	serotonin	5-HT1B	MESH:D012701	25075(Tax:10116)	Chemical	Gene	action|nmod|START_ENTITY mediated|nsubjpass|action mediated|nmod|stimulation stimulation|nmod|receptors receptors|nummod|END_ENTITY	Further evidence showing that the inhibitory action of serotonin on rat masculine sexual_behavior is mediated after the stimulation of 5-HT1B receptors .
1449511	0	serotonin	36,45	5-HT1B	66,72	serotonin	5-HT1B	MESH:D012701	25075(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|nmod|phenotype phenotype|nummod|END_ENTITY	Conversion of the human 5-HT1D beta serotonin receptor to the rat 5-HT1B ligand-binding phenotype by Thr355Asn site directed mutagenesis .
1548463	0	serotonin	69,78	5-HT1B	79,85	serotonin	5-HT1B	MESH:D012701	25075(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|nummod|END_ENTITY	Characterization of -LSB- 3H -RSB- CP-96 ,501 as a selective radioligand for the serotonin 5-HT1B receptor : binding studies in rat brain membranes .
15572052	0	serotonin	22,31	5-HT1B	129,135	serotonin	5-HT1B	MESH:D012701	403741(Tax:9615)	Chemical	Gene	5-HT2A_receptor|compound|START_ENTITY blockade|nmod|5-HT2A_receptor increases|nsubj|blockade increases|nmod|receptor receptor|nummod|END_ENTITY	Selective blockade of serotonin 5-HT2A_receptor increases coronary blood flow via augmented cardiac nitric_oxide release through 5-HT1B receptor in hypoperfused canine hearts .
15670643	0	serotonin	42,51	5-HT1B	10,16	serotonin	5-HT1B	MESH:D012701	3351	Chemical	Gene	reduces|iobj|START_ENTITY reduces|nsubj|agonist agonist|nummod|END_ENTITY	Selective 5-HT1B receptor agonist reduces serotonin synthesis following acute , and not chronic , drug administration : results of an autoradiographic study .
1678720	0	serotonin	65,74	5-HT1B	83,89	serotonin	5-HT1B	MESH:D012701	3351	Chemical	Gene	START_ENTITY|dep|5-HT1A 5-HT1A|nummod|END_ENTITY	Interaction of the alpha-adrenoceptor agonist oxymetazoline with serotonin 5-HT1A , 5-HT1B , 5-HT1C and 5-HT1D receptors .
17291490	0	serotonin	11,20	5-HT1B	21,27	serotonin	5-HT1B	MESH:D012701	25075(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|nummod|END_ENTITY	Effects of serotonin 5-HT1B receptor ligands on the cocaine - and food-maintained self-administration in rats .
1852219	0	serotonin	35,44	5-HT1B	67,73	serotonin	5-HT1B	MESH:D012701	25075(Tax:10116)	Chemical	Gene	autoreceptors|compound|START_ENTITY differences|nmod|autoreceptors differences|dep|END_ENTITY	Species differences in presynaptic serotonin autoreceptors : mainly 5-HT1B but possibly in addition 5-HT1D in the rat , 5-HT1D in the rabbit and guinea-pig brain cortex .
1913239	0	serotonin	55,64	5-HT1B	88,94	serotonin	5-HT1B	MESH:D012701	25075(Tax:10116)	Chemical	Gene	specific|amod|START_ENTITY specific|nmod|END_ENTITY	-LSB- Synthesis and pharmacological study of radioiodinated serotonin derivative specific of 5-HT1B and 5-HT1D binding sites of the central nervous system -RSB- .
22493371	0	serotonin	14,23	5-HT1B	42,48	serotonin	5-HT1B	MESH:D012701	3351	Chemical	Gene	Expression|nmod|START_ENTITY Expression|amod|receptors receptors|dep|5-HT1A 5-HT1A|nummod|END_ENTITY	Expression of serotonin receptors 5-HT1A , 5-HT1B , 5-HT2B and 5-HT4 in ovary and in ovarian_tumours .
2364979	0	serotonin	53,62	5-HT1B	64,70	serotonin	5-HT1B	MESH:D012701	15551(Tax:10090)	Chemical	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Chronic but not acute antidepressants interfere with serotonin -LRB- 5-HT1B -RRB- receptors .
23659057	0	serotonin	62,71	5-HT1B	55,61	serotonin	5-HT1B	MESH:D012701	3351	Chemical	Gene	receptors|compound|START_ENTITY receptors|nummod|END_ENTITY	-LSB- Regulation of potential-dependant calcium channels by 5-HT1B serotonin receptors in various populations of hippocampal cells -RSB- .
3662697	0	serotonin	23,32	5-HT1B	127,133	serotonin	5-HT1B	MESH:D012701	25075(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY RU_24969|nmod|release Effects|nmod|RU_24969 Effects|dep|support support|nmod|identity identity|nmod|autoreceptors autoreceptors|nmod|sites sites|nummod|END_ENTITY	Effects of RU_24969 on serotonin release in rat brain cortex : further support for the identity of serotonin autoreceptors with 5-HT1B sites .
3662697	0	serotonin	98,107	5-HT1B	127,133	serotonin	5-HT1B	MESH:D012701	25075(Tax:10116)	Chemical	Gene	autoreceptors|compound|START_ENTITY autoreceptors|nmod|sites sites|nummod|END_ENTITY	Effects of RU_24969 on serotonin release in rat brain cortex : further support for the identity of serotonin autoreceptors with 5-HT1B sites .
8782828	0	serotonin	64,73	5-HT1B	57,63	serotonin	5-HT1B	MESH:D012701	15551(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|nummod|END_ENTITY	Elevated alcohol consumption in null mutant mice lacking 5-HT1B serotonin receptors .
8922413	0	serotonin	24,33	5-HT1B	47,53	serotonin	5-HT1B	MESH:D012701	25075(Tax:10116)	Chemical	Gene	START_ENTITY|acl|mediated mediated|nmod|receptors receptors|compound|END_ENTITY	Differential actions of serotonin , mediated by 5-HT1B and 5-HT2C receptors , on GABA-mediated synaptic input to rat substantia nigra pars reticulata neurons in vitro .
9555084	0	serotonin	132,141	5-HT1B	29,35	serotonin	5-HT1B	MESH:D012701	3351	Chemical	Gene	reinnervation|compound|START_ENTITY reversed|nmod|reinnervation reversed|nsubjpass|up-regulation up-regulation|nmod|sites sites|nummod|END_ENTITY	Post-lesion up-regulation of 5-HT1B binding sites in the suprachiasmatic nucleus may be reversed after spontaneous or graft-induced serotonin reinnervation .
9630549	0	serotonin	23,32	5-HT1B	33,39	serotonin	5-HT1B	MESH:D012701	25075(Tax:10116)	Chemical	Gene	increases|nmod|START_ENTITY 1D|dep|increases 1D|dep|/ /|nummod|END_ENTITY	Selective increases in serotonin 5-HT1B / 1D and 5-HT2A / 2C binding sites in adult rat basal ganglia following lesions of serotonergic neurons .
9721730	0	serotonin	12,21	5-HT1B	22,28	serotonin	5-HT1B	MESH:D012701	100689321	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Coupling of serotonin 5-HT1B receptors to activation of mitogen-activated protein kinase -LRB- ERK-2 -RRB- and p70 S6 kinase signaling systems .
9819067	0	serotonin	40,49	5-HT1B	50,56	serotonin	5-HT1B	MESH:D012701	3351	Chemical	Gene	gene|compound|START_ENTITY gene|nummod|END_ENTITY	Linkage of antisocial alcoholism to the serotonin 5-HT1B receptor gene in 2 populations .
10101609	0	serotonin	95,104	5-HT1B_receptor	40,55	serotonin	5-HT1B receptor	MESH:D012701	15551(Tax:10090)	Chemical	Gene	inhibitors|compound|START_ENTITY END_ENTITY|nmod|inhibitors	-LSB- Homozygote mice deficient in serotonin 5-HT1B_receptor and antidepressant effect of selective serotonin reuptake inhibitors -RSB- .
1381232	0	serotonin	56,65	5-HT1C	23,29	serotonin	5-HT1C	MESH:D012701	15560(Tax:10090)	Chemical	Gene	genes|amod|START_ENTITY fundus|dobj|genes fundus|nsubj|Structure Structure|nmod|END_ENTITY	Structure of the mouse 5-HT1C , 5-HT2 and stomach fundus serotonin receptor genes .
1542100	0	serotonin	60,69	5-HT1C	43,49	serotonin	5-HT1C	MESH:D012701	3358	Chemical	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	Binding of phenylalkylamine derivatives at 5-HT1C and 5-HT2 serotonin receptors : evidence for a lack of selectivity .
1776132	0	serotonin	24,33	5-HT1C	106,112	serotonin	5-HT1C	MESH:D012701	25187(Tax:10116)	Chemical	Gene	responses|nmod|START_ENTITY responses|dep|evidence evidence|nmod|mediation mediation|nmod|receptors receptors|nummod|END_ENTITY	Excitatory responses to serotonin -LRB- 5-HT -RRB- in neurons of the rat piriform cortex : evidence for mediation by 5-HT1C receptors in pyramidal cells and 5-HT2 receptors in interneurons .
2714444	0	serotonin	16,25	5-HT1C	26,32	serotonin	5-HT1C	MESH:D012701	25187(Tax:10116)	Chemical	Gene	mRNA|compound|START_ENTITY mRNA|nummod|END_ENTITY	Distribution of serotonin 5-HT1C receptor mRNA in adult rat brain .
1521164	0	serotonin	33,42	5-HT1D	43,49	serotonin	5-HT1D	MESH:D012701	15552(Tax:10090)	Chemical	Gene	sequences|compound|START_ENTITY sequences|nummod|END_ENTITY	Molecular cloning of two partial serotonin 5-HT1D receptor sequences in mouse and one in guinea_pig .
1559993	0	serotonin	29,38	5-HT1D	108,114	serotonin	5-HT1D	MESH:D012701	3352	Chemical	Gene	receptor|compound|START_ENTITY Molecular|nmod|receptor Molecular|nmod|profile profile|acl|resembling resembling|xcomp|that that|nmod|subtype subtype|nummod|END_ENTITY	Molecular cloning of a human serotonin receptor -LRB- S12 -RRB- with a pharmacological profile resembling that of the 5-HT1D subtype .
1641195	0	serotonin	86,95	5-HT1D	48,54	serotonin	5-HT1D	MESH:D012701	3352	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|5-CT-sensitive 5-CT-sensitive|dep|END_ENTITY	Quantitative autoradiography of 5-CT-sensitive -LRB- 5-HT1D -RRB- and 5-CT-insensitive -LRB- 5-HT1E -RRB- serotonin receptors in human brain .
1852219	0	serotonin	35,44	5-HT1D	118,124	serotonin	5-HT1D	MESH:D012701	25323(Tax:10116)	Chemical	Gene	autoreceptors|compound|START_ENTITY differences|nmod|autoreceptors differences|dep|5-HT1B 5-HT1B|nmod|rat rat|appos|END_ENTITY	Species differences in presynaptic serotonin autoreceptors : mainly 5-HT1B but possibly in addition 5-HT1D in the rat , 5-HT1D in the rabbit and guinea-pig brain cortex .
1852219	0	serotonin	35,44	5-HT1D	99,105	serotonin	5-HT1D	MESH:D012701	25323(Tax:10116)	Chemical	Gene	autoreceptors|compound|START_ENTITY differences|nmod|autoreceptors differences|dep|5-HT1B 5-HT1B|nmod|addition addition|nummod|END_ENTITY	Species differences in presynaptic serotonin autoreceptors : mainly 5-HT1B but possibly in addition 5-HT1D in the rat , 5-HT1D in the rabbit and guinea-pig brain cortex .
2215849	0	serotonin	4,13	5-HT1D	14,20	serotonin	5-HT1D	MESH:D012701	3352	Chemical	Gene	receptor|compound|START_ENTITY receptor|nummod|END_ENTITY	The serotonin 5-HT1D receptor : a progress review .
2523233	0	serotonin	47,56	5-HT1D	57,63	serotonin	5-HT1D	MESH:D012701	25323(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Postsynaptic localization and up-regulation of serotonin 5-HT1D receptors in rat brain .
3399126	0	serotonin	25,34	5-HT1D	53,59	serotonin	5-HT1D	MESH:D012701	3352	Chemical	Gene	site|compound|START_ENTITY Visualization|nmod|site Visualization|appos|END_ENTITY	Visualization of a novel serotonin recognition site -LRB- 5-HT1D -RRB- in the human brain by autoradiography .
7595565	0	serotonin	26,35	5-HT1D	36,42	serotonin	5-HT1D	MESH:D012701	397309(Tax:9823)	Chemical	Gene	receptors|compound|START_ENTITY receptors|nummod|END_ENTITY	Immunolabeling of central serotonin 5-HT1D beta receptors in the rat , mouse , and guinea_pig with a specific anti-peptide antiserum .
7775648	0	serotonin	12,21	5-HT1D	39,45	serotonin	5-HT1D	MESH:D012701	3352	Chemical	Gene	receptor|compound|START_ENTITY Role|nmod|receptor subtype|nsubj|Role subtype|dobj|END_ENTITY	Role of the serotonin receptor subtype 5-HT1D on basal and stimulated growth_hormone secretion .
7805767	0	serotonin	73,82	5-HT1D	0,6	serotonin	5-HT1D	MESH:D012701	3352	Chemical	Gene	involved|nmod|START_ENTITY involved|nsubjpass|type type|nummod|END_ENTITY	5-HT1D receptor type is involved in stimulation of cell proliferation by serotonin in human small_cell_lung_carcinoma .
8082225	0	serotonin	105,114	5-HT1D	20,26	serotonin	5-HT1D	MESH:D012701	100379622(Tax:10141)	Chemical	Gene	display|nmod|START_ENTITY display|nsubj|autoreceptors autoreceptors|compound|END_ENTITY	Guinea_pig terminal 5-HT1D autoreceptors do not display a circadian variation in their responsiveness to serotonin .
8841890	0	serotonin	28,37	5-HT1D	46,52	serotonin	5-HT1D	MESH:D012701	3352	Chemical	Gene	START_ENTITY|dep|5-HT1A 5-HT1A|nummod|END_ENTITY	Autoradiographic mapping of serotonin 5-HT1A , 5-HT1D , 5-HT2A and 5-HT3 receptors in the aged human spinal cord .
8978753	0	serotonin	62,71	5-HT1D	72,78	serotonin	5-HT1D	MESH:D012701	25323(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Sequence and functional analysis of cloned guinea_pig and rat serotonin 5-HT1D receptors : common pharmacological features within the 5-HT1D receptor subfamily .
8170966	0	serotonin	23,32	5-HT1D_alpha	10,22	serotonin	5-HT1D alpha	MESH:D012701	3352	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Selective 5-HT1D_alpha serotonin receptor gene expression in trigeminal ganglia : implications for antimigraine drug development .
7485252	0	serotonin	15,24	5-HT1D_beta	25,36	serotonin	5-HT1D beta	MESH:D012701	3351	Chemical	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Mapping of the serotonin 5-HT1D_beta autoreceptor gene on chromosome 6 and direct analysis for sequence variants .
8568822	0	serotonin	34,43	5-HT1D_beta	53,64	serotonin	5-HT1D beta	MESH:D012701	3351	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|receptors receptors|amod|END_ENTITY	Binding of O-alkyl derivatives of serotonin at human 5-HT1D_beta receptors .
9435911	0	serotonin	84,93	5-HT1D_beta	62,73	serotonin	5-HT1D beta	MESH:D012701	3351	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	2 - -LRB- 1-Naphthyloxy -RRB- ethylamines with enhanced affinity for human 5-HT1D_beta -LRB- h5-HT1B -RRB- serotonin receptors .
2664084	0	serotonin	21,30	5-HT1E	49,55	serotonin	5-HT1E	MESH:D012701	3354	Chemical	Gene	subtype|compound|START_ENTITY subtype|appos|END_ENTITY	Detection of a novel serotonin receptor subtype -LRB- 5-HT1E -RRB- in human brain : interaction with a GTP-binding protein .
8001977	0	serotonin	43,52	5-HT1E	36,42	serotonin	5-HT1E	MESH:D012701	3354	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Assignment of the gene encoding the 5-HT1E serotonin receptor -LRB- S31 -RRB- -LRB- locus HTR1E -RRB- to human chromosome 6q14-q15 .
11059260	0	serotonin	27,36	5-HT1a	20,26	serotonin	5-HT1a	MESH:D012701	24473(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	-LSB- The involvement of 5-HT1a serotonin receptors in the pathophysiology and pharmacotherapy of schizophrenia -RSB- .
20721314	0	serotonin	24,33	5-HT1a	44,50	serotonin	5-HT1a	MESH:D012701	3350	Chemical	Gene	effects|nmod|START_ENTITY receptors|nsubj|effects receptors|dobj|END_ENTITY	Oppositional effects of serotonin receptors 5-HT1a , 2 , and 2c in the regulation of adult hippocampal neurogenesis .
9051259	0	serotonin	52,61	5-HT1a	0,6	serotonin	5-HT1a	MESH:D012701	24473(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY mediate|dobj|effect mediate|nsubj|receptors receptors|amod|END_ENTITY	5-HT1a receptors mediate the neurotrophic effect of serotonin on developing dentate granule cells .
2108241	0	serotonin	17,26	5-HT1b	85,91	serotonin	5-HT1b	MESH:D012701	15551(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY exhibit|nsubj|receptors exhibit|nmod|receptors receptors|amod|END_ENTITY	G-protein-linked serotonin receptors in mouse kidney exhibit identical properties to 5-HT1b receptors in brain .
18162482	0	serotonin	129,138	5-HT2	139,144	serotonin	5-HT2	MESH:D012701	29595(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|receptors receptors|nummod|END_ENTITY	Maintenance of gasping and restoration of eupnea after hypoxia is impaired following blockers of alpha1-adrenergic receptors and serotonin 5-HT2 receptors .
10081968	0	serotonin	44,53	5-HT2A	54,60	serotonin	5-HT2A	MESH:D012701	3356	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Relationship between central and peripheral serotonin 5-HT2A receptors : a positron emission tomography study in healthy individuals .
10198219	0	serotonin	40,49	5-HT2A	32,38	serotonin	5-HT2A	MESH:D012701	29595(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|nummod|END_ENTITY	Biochemical localisation of the 5-HT2A -LRB- serotonin -RRB- receptor in rat skeletal muscle .
10203244	0	serotonin	20,29	5-HT2A	30,36	serotonin	5-HT2A	MESH:D012701	15558(Tax:10090)	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Adaptive changes of serotonin 5-HT2A receptors in mice lacking the serotonin transporter .
10203244	0	serotonin	67,76	5-HT2A	30,36	serotonin	5-HT2A	MESH:D012701	15558(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY lacking|dobj|transporter changes|acl|lacking changes|nmod|receptors receptors|amod|END_ENTITY	Adaptive changes of serotonin 5-HT2A receptors in mice lacking the serotonin transporter .
10774780	0	serotonin	17,26	5-HT2A	85,91	serotonin	5-HT2A	MESH:D012701	29595(Tax:10116)	Chemical	Gene	_|compound|START_ENTITY AT-1015|appos|_ blocks|nsubj|AT-1015 blocks|dobj|receptors receptors|nummod|END_ENTITY	AT-1015 , a novel serotonin _ -LRB- 5-HT -RRB- 2 receptor antagonist , blocks vascular and platelet 5-HT2A receptors and prevents the laurate-induced peripheral_vascular_lesion in rats .
10821438	0	serotonin	99,108	5-HT2A	109,115	serotonin	5-HT2A	MESH:D012701	29595(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|receptors receptors|nummod|END_ENTITY	Differential effects of subchronic treatments with atypical antipsychotic drugs on dopamine D2 and serotonin 5-HT2A receptors in the rat brain .
11403977	0	serotonin	29,38	5-HT2A	93,99	serotonin	5-HT2A	MESH:D012701	3356	Chemical	Gene	sites|amod|START_ENTITY paroxetine|nmod|sites -RSB-|amod|paroxetine Binding|nmod|-RSB- lysergic_acid_diethylamide|nsubj|Binding lysergic_acid_diethylamide|nmod|receptors receptors|nummod|END_ENTITY	Binding of -LSB- 3H -RSB- paroxetine to serotonin uptake sites and of -LSB- 3H -RSB- lysergic_acid_diethylamide to 5-HT2A receptors in platelets from women with premenstrual_dysphoric_disorder during gonadotropin_releasing_hormone treatment .
12097814	0	serotonin	18,27	5-HT2A	0,6	serotonin	5-HT2A	MESH:D012701	15558(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	5-HT2A and 5-HT2C serotonin receptors differentially modulate mouse sexual arousal and the hypothalamo-pituitary-testicular response to the presence of a female .
12614326	0	serotonin	68,77	5-HT2A	37,43	serotonin	5-HT2A	MESH:D012701	15558(Tax:10090)	Chemical	Gene	mice|amod|START_ENTITY alterations|nmod|mice alterations|nmod|receptors receptors|compound|END_ENTITY	Brain region-specific alterations of 5-HT2A and 5-HT2C receptors in serotonin transporter knockout mice .
12682061	0	serotonin	43,52	5-HT2A	36,42	serotonin	5-HT2A	MESH:D012701	3356	Chemical	Gene	receptors|compound|START_ENTITY receptors|nummod|END_ENTITY	A direct interaction of PSD-95 with 5-HT2A serotonin receptors regulates receptor trafficking and signal transduction .
14730096	0	serotonin	46,55	5-HT2A	39,45	serotonin	5-HT2A	MESH:D012701	29595(Tax:10116)	Chemical	Gene	activity|compound|START_ENTITY activity|nummod|END_ENTITY	Synthesis , in vitro and in vivo 5-HT1A / 5-HT2A serotonin receptor activity of new hybrid 1,2,3,4-tetrahydro-gamma-carbolines with 1 - -LRB- 2-methoxyphenyl -RRB- piperazine moiety .
15127084	0	serotonin	4,13	5-HT2A	14,20	serotonin	5-HT2A	MESH:D012701	29595(Tax:10116)	Chemical	Gene	START_ENTITY|dep|receptors receptors|nummod|END_ENTITY	The serotonin 5-HT2A receptors antagonist M100907 prevents impairment in attentional performance by NMDA receptor blockade in the rat prefrontal cortex .
15999145	0	serotonin	52,61	5-HT2A	45,51	serotonin	5-HT2A	MESH:D012701	29595(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|nummod|END_ENTITY	Evidence for the preferential involvement of 5-HT2A serotonin receptors in stress - and drug-induced dopamine release in the rat medial prefrontal cortex .
16300424	0	serotonin	78,87	5-HT2A	88,94	serotonin	5-HT2A	MESH:D012701	29595(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Relationship of cocaine-induced c-Fos expression to behaviors and the role of serotonin 5-HT2A receptors in cocaine-induced c-Fos expression .
16382194	0	serotonin	41,50	5-HT2A	23,29	serotonin	5-HT2A	MESH:D012701	3356	Chemical	Gene	START_ENTITY|nsubj|studies studies|nmod|END_ENTITY	Association studies of 5-HT2A and 5-HT2C serotonin receptor gene polymorphisms with prophylactic lithium response in bipolar patients .
17617023	0	serotonin	59,68	5-HT2A	82,88	serotonin	5-HT2A	MESH:D012701	3356	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Association between T102C and A-1438G polymorphisms in the serotonin receptor 2A -LRB- 5-HT2A -RRB- gene and schizophrenia : relevance for treatment with antipsychotic drugs .
19103592	0	serotonin	82,91	5-HT2A	121,127	serotonin	5-HT2A	MESH:D012701	3356	Chemical	Gene	receptor|compound|START_ENTITY receptor|acl|modulating modulating|dobj|signaling signaling|nummod|END_ENTITY	Ribosomal_S6_kinase_2 directly phosphorylates the 5-hydroxytryptamine_2A -LRB- 5-HT2A -RRB- serotonin receptor , thereby modulating 5-HT2A signaling .
20456331	0	serotonin	39,48	5-HT2A	15,21	serotonin	5-HT2A	MESH:D012701	29595(Tax:10116)	Chemical	Gene	syndrome|amod|START_ENTITY receptors|nmod|syndrome receptors|nummod|END_ENTITY	Involvement of 5-HT2A receptors in the serotonin -LRB- 5-HT -RRB- syndrome caused by excessive 5-HT efflux in rat brain .
21782029	0	serotonin	33,42	5-HT2A	47,53	serotonin	5-HT2A	MESH:D012701	3356	Chemical	Gene	characterisation|nmod|START_ENTITY characterisation|appos|END_ENTITY	Extended characterisation of the serotonin 2A -LRB- 5-HT2A -RRB- receptor-selective PET radiotracer 11C-MDL100907 in humans : quantitative analysis , test-retest reproducibility , and vulnerability to endogenous 5-HT tone .
21874578	1	serotonin	89,98	5-HT2A	82,88	serotonin	5-HT2A	MESH:D012701	15558(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|nummod|END_ENTITY	In vivo evidence for partial agonist effects of -LRB- - -RRB- - OSU6162 and -LRB- + -RRB- - OSU6162 on 5-HT2A serotonin receptors .
23034456	0	serotonin	26,35	5-HT2A	49,55	serotonin	5-HT2A	MESH:D012701	3356	Chemical	Gene	receptor|compound|START_ENTITY selectivity|nmod|receptor selectivity|appos|END_ENTITY	Functional selectivity in serotonin receptor 2A -LRB- 5-HT2A -RRB- endocytosis , recycling , and phosphorylation .
23146656	0	serotonin	46,55	5-HT2A	56,62	serotonin	5-HT2A	MESH:D012701	3356	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Glucocorticoid treatment increases density of serotonin 5-HT2A receptors in humans .
23380172	0	serotonin	7,16	5-HT2A	0,6	serotonin	5-HT2A	MESH:D012701	3356	Chemical	Gene	alleviates|compound|START_ENTITY alleviates|nummod|END_ENTITY	5-HT2A serotonin receptor agonist DOI alleviates cytotoxicity in neuroblastoma cells : role of the ERK pathway .
23404493	1	serotonin	125,134	5-HT2A	149,155	serotonin	5-HT2A	MESH:D012701	3356	Chemical	Gene	START_ENTITY|appos|Rs Rs|nummod|END_ENTITY	Prefrontal serotonin 2A receptors -LRB- 5-HT2A Rs -RRB- have been linked to the pathogenesis and treatment of schizophrenia .
24949809	0	serotonin	13,22	5-HT2A	107,113	serotonin	5-HT2A	MESH:D012701	29595(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY role|dep|Involvement Involvement|nmod|5-HT1A 5-HT1A|nummod|END_ENTITY	Dual role of serotonin in the acquisition and extinction of reward-driven learning : Involvement of 5-HT1A , 5-HT2A and 5-HT3 receptors .
7617676	0	serotonin	7,16	5-HT2A	0,6	serotonin	5-HT2A	MESH:D012701	15558(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|nummod|END_ENTITY	5-HT2A serotonin receptors in the brain of rats and mice hereditarily predisposed to catalepsy .
7988407	0	serotonin	20,29	5-HT2A	41,47	serotonin	5-HT2A	MESH:D012701	3356	Chemical	Gene	START_ENTITY|dep|receptors receptors|nummod|END_ENTITY	-LSB- The role of type 2 serotonin receptors , 5-HT2A and 5-HT2C , in depressive_disorders : effect of medifoxamine -RSB- .
8028479	0	serotonin	20,29	5-HT2A	78,84	serotonin	5-HT2A	MESH:D012701	29595(Tax:10116)	Chemical	Gene	mRNAs|amod|START_ENTITY Distribution|nmod|mRNAs Distribution|dep|comparison comparison|nmod|receptors receptors|compound|END_ENTITY	Distribution of the serotonin 5-HT2 receptor family mRNAs : comparison between 5-HT2A and 5-HT2C receptors .
8642415	0	serotonin	50,59	5-HT2A	60,66	serotonin	5-HT2A	MESH:D012701	29595(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|nummod|END_ENTITY	Dopamine receptor agonists regulate levels of the serotonin 5-HT2A receptor and its mRNA in a subpopulation of rat striatal neurons .
8788517	0	serotonin	29,38	5-HT2A	39,45	serotonin	5-HT2A	MESH:D012701	3356	Chemical	Gene	facilitation|amod|START_ENTITY facilitation|amod|END_ENTITY	Ca2 + mobilizing agents mimic serotonin 5-HT2A facilitation of N-methyl-D-aspartate depolarization .
8799865	0	serotonin	18,27	5-HT2A	46,52	serotonin	5-HT2A	MESH:D012701	29595(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY Colocalization|nmod|receptor subtypes|nsubj|Colocalization subtypes|dobj|END_ENTITY	Colocalization of serotonin receptor subtypes 5-HT2A , 5-HT2C , and 5-HT6 with neuropeptides in rat striatum .
8841890	0	serotonin	28,37	5-HT2A	54,60	serotonin	5-HT2A	MESH:D012701	3356	Chemical	Gene	START_ENTITY|dep|5-HT1A 5-HT1A|nummod|END_ENTITY	Autoradiographic mapping of serotonin 5-HT1A , 5-HT1D , 5-HT2A and 5-HT3 receptors in the aged human spinal cord .
9188767	0	serotonin	22,31	5-HT2A	32,38	serotonin	5-HT2A	MESH:D012701	29595(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY ligand|nmod|regulation ligand|nsubj|receptors receptors|nummod|END_ENTITY	In vivo regulation of serotonin 5-HT2A receptors in rat brain by subchronic administration of sigma receptor ligand NE-100 .
9539697	0	serotonin	46,55	5-HT2A	28,34	serotonin	5-HT2A	MESH:D012701	3356	Chemical	Gene	START_ENTITY|nsubj|requirements requirements|nmod|END_ENTITY	Structural requirements for 5-HT2A and 5-HT1A serotonin receptor potentiation by the biologically active lipid oleamide .
9572479	0	serotonin	109,118	5-HT2A	123,129	serotonin	5-HT2A	MESH:D012701	29595(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|receptors receptors|nummod|END_ENTITY	Signaling pathways mediating induction of the early response genes prostaglandin_G / H synthase-2 and egr-1 by serotonin via 5-HT2A receptors .
9833645	0	serotonin	30,39	5-HT2A	23,29	serotonin	5-HT2A	MESH:D012701	3356	Chemical	Gene	receptors|compound|START_ENTITY receptors|nummod|END_ENTITY	-LSB- 3H -RSB- MDL_100 ,907 labels 5-HT2A serotonin receptors selectively in primate brain .
12892843	0	serotonin	28,37	5-HT2A_receptor	38,53	serotonin	5-HT2A receptor	MESH:D012701	3356	Chemical	Gene	START_ENTITY|dep|antagonist antagonist|amod|END_ENTITY	EMD_281014 , a new selective serotonin 5-HT2A_receptor antagonist .
11378296	0	serotonin	26,35	5-HT2B	36,42	serotonin	5-HT2B	MESH:D012701	41017(Tax:7227)	Chemical	Gene	START_ENTITY|dep|receptors receptors|nummod|END_ENTITY	Developmentally regulated serotonin 5-HT2B receptors .
11744166	0	serotonin	4,13	5-HT2B	14,20	serotonin	5-HT2B	MESH:D012701	3357	Chemical	Gene	receptor|compound|START_ENTITY receptor|nummod|END_ENTITY	The serotonin 5-HT2B receptor from the puffer fish Tetraodon fluviatilis : cDNA cloning , genomic organization and alternatively spliced variants .
11859080	0	serotonin	4,13	5-HT2B	47,53	serotonin	5-HT2B	MESH:D012701	15559(Tax:10090)	Chemical	Gene	site|compound|START_ENTITY site|nmod|receptors receptors|amod|END_ENTITY	The serotonin binding site of human and murine 5-HT2B receptors : molecular modeling and site-directed mutagenesis .
12810613	0	serotonin	22,31	5-HT2B	32,38	serotonin	5-HT2B	MESH:D012701	15559(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|nummod|END_ENTITY	Overexpression of the serotonin 5-HT2B receptor in heart leads to abnormal mitochondrial function and cardiac_hypertrophy .
15302781	0	serotonin	19,28	5-HT2B	29,35	serotonin	5-HT2B	MESH:D012701	15559(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|nummod|END_ENTITY	Involvement of the serotonin 5-HT2B receptor in cardiac_hypertrophy linked to sympathetic stimulation : control of interleukin-6 , interleukin-1beta , and tumor_necrosis_factor-alpha cytokine production by ventricular fibroblasts .
17854596	0	serotonin	10,19	5-HT2B	100,106	serotonin	5-HT2B	MESH:D012701	15559(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|receptors receptors|nummod|END_ENTITY	Exogenous serotonin regulates proliferation of interstitial cells of Cajal in mouse jejunum through 5-HT2B receptors .
18703043	0	serotonin	46,55	5-HT2B	64,70	serotonin	5-HT2B	MESH:D012701	3357	Chemical	Gene	START_ENTITY|dep|5-HT2A 5-HT2A|nummod|END_ENTITY	Agonist-directed trafficking of signalling at serotonin 5-HT2A , 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells .
19956756	0	serotonin	8,17	5-HT2B	22,28	serotonin	5-HT2B	MESH:D012701	15559(Tax:10090)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|receptors receptors|nummod|END_ENTITY	Role of serotonin via 5-HT2B receptors in the reinforcing effects of MDMA in mice .
22493371	0	serotonin	14,23	5-HT2B	50,56	serotonin	5-HT2B	MESH:D012701	3357	Chemical	Gene	Expression|nmod|START_ENTITY Expression|amod|receptors receptors|dep|5-HT1A 5-HT1A|nummod|END_ENTITY	Expression of serotonin receptors 5-HT1A , 5-HT1B , 5-HT2B and 5-HT4 in ovary and in ovarian_tumours .
7920184	0	serotonin	72,81	5-HT2B	10,16	serotonin	5-HT2B	MESH:D012701	15559(Tax:10090)	Chemical	Gene	functions|nmod|START_ENTITY involvement|nmod|functions receptor|dep|involvement receptor|nummod|END_ENTITY	The mouse 5-HT2B receptor : possible involvement in trophic functions of serotonin .
9165122	0	serotonin	25,34	5-HT2B	0,6	serotonin	5-HT2B	MESH:D012701	15559(Tax:10090)	Chemical	Gene	functions|amod|START_ENTITY functions|nummod|END_ENTITY	5-HT2B receptor-mediated serotonin morphogenetic functions in mouse cranial neural crest and myocardiac cells .
9178521	0	serotonin	49,58	5-HT2B	31,37	serotonin	5-HT2B	MESH:D012701	29581(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|affinity affinity|nmod|5-HT2A 5-HT2A|nummod|END_ENTITY	Synthesis , affinity at 5-HT2A , 5-HT2B and 5-HT2C serotonin receptors and structure-activity relationships of a series of cyproheptadine analogues .
9928240	0	serotonin	31,40	5-HT2B	6,12	serotonin	5-HT2B	MESH:D012701	15559(Tax:10090)	Chemical	Gene	functions|amod|START_ENTITY receptor-mediated|dobj|functions receptor-mediated|nsubj|END_ENTITY	Mouse 5-HT2B receptor-mediated serotonin trophic functions .
15652696	0	serotonin	14,23	5-HT2C	24,30	serotonin	5-HT2C	MESH:D012701	25187(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Expression of serotonin 5-HT2C receptors in GABAergic cells of the anterior raphe nuclei .
18095642	0	serotonin	134,143	5-HT2C	144,150	serotonin	5-HT2C	MESH:D012701	25187(Tax:10116)	Chemical	Gene	agonist|compound|START_ENTITY agonist|nummod|END_ENTITY	Discovery and structure-activity relationship of -LRB- 1R -RRB- -8 - chloro-2 ,3,4,5 - tetrahydro-1-methyl-1H-3-benzazepine -LRB- Lorcaserin -RRB- , a selective serotonin 5-HT2C receptor agonist for the treatment of obesity .
19403919	0	serotonin	72,81	5-HT2C	115,121	serotonin	5-HT2C	MESH:D012701	3358	Chemical	Gene	analogs|nmod|START_ENTITY labeled|dobj|analogs labeled|nmod|screening screening|nmod|receptor receptor|nummod|END_ENTITY	Design , synthesis , and pharmacology of fluorescently labeled analogs of serotonin : application to screening of the 5-HT2C receptor .
20570529	0	serotonin	133,142	5-HT2C	159,165	serotonin	5-HT2C	MESH:D012701	3358	Chemical	Gene	START_ENTITY|appos|receptor receptor|nummod|END_ENTITY	Synthesis and structure-affinity relationships of novel small molecule natural product derivatives capable of discriminating between serotonin 5-HT1A , 5-HT2A , 5-HT2C receptor subtypes .
25596490	0	serotonin	4,13	5-HT2C	65,71	serotonin	5-HT2C	MESH:D012701	3358	Chemical	Gene	transporter|compound|START_ENTITY transporter|nmod|variant variant|appos|Cys23Ser Cys23Ser|nummod|END_ENTITY	The serotonin transporter -LRB- 5-HTTLPR -RRB- but not serotonin receptor -LRB- 5-HT2C Cys23Ser -RRB- variant is associated with bipolar_I_disorder in Kurdish population from Western Iran .
25596490	0	serotonin	45,54	5-HT2C	65,71	serotonin	5-HT2C	MESH:D012701	3358	Chemical	Gene	variant|amod|START_ENTITY variant|appos|Cys23Ser Cys23Ser|nummod|END_ENTITY	The serotonin transporter -LRB- 5-HTTLPR -RRB- but not serotonin receptor -LRB- 5-HT2C Cys23Ser -RRB- variant is associated with bipolar_I_disorder in Kurdish population from Western Iran .
25720309	0	serotonin	26,35	5-HT2C	46,52	serotonin	5-HT2C	MESH:D012701	25187(Tax:10116)	Chemical	Gene	Expression|nmod|START_ENTITY receptors|nsubj|Expression receptors|dobj|END_ENTITY	Expression of hippocampal serotonin receptors 5-HT2C and 5-HT5A in a rat model of diet-induced obesity supplemented with tryptophan .
26145279	0	serotonin	7,16	5-HT2C	0,6	serotonin	5-HT2C	MESH:D012701	15560(Tax:10090)	Chemical	Gene	blockade|amod|START_ENTITY blockade|nummod|END_ENTITY	5-HT2C serotonin receptor blockade prevents tau protein hyperphosphorylation and corrects the defect in hippocampal synaptic plasticity caused by a combination of environmental stressors in mice .
7851496	0	serotonin	14,23	5-HT2C	24,30	serotonin	5-HT2C	MESH:D012701	25187(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Regulation of serotonin 5-HT2C receptors in the rat choroid plexus after acute clozapine treatment .
8750891	0	serotonin	22,31	5-HT2C	32,38	serotonin	5-HT2C	MESH:D012701	25187(Tax:10116)	Chemical	Gene	Identification|nmod|START_ENTITY glycoproteins|nsubj|Identification glycoproteins|advmod|as as|nmod:npmod|receptors receptors|nummod|END_ENTITY	Identification of rat serotonin 5-HT2C receptors as glycoproteins containing N-linked oligosaccharides .
8799865	0	serotonin	18,27	5-HT2C	54,60	serotonin	5-HT2C	MESH:D012701	25187(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY Colocalization|nmod|receptor subtypes|nsubj|Colocalization subtypes|dobj|5-HT2A 5-HT2A|nummod|END_ENTITY	Colocalization of serotonin receptor subtypes 5-HT2A , 5-HT2C , and 5-HT6 with neuropeptides in rat striatum .
9326273	0	serotonin	4,13	5-HT2C	14,20	serotonin	5-HT2C	MESH:D012701	25187(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|nummod|END_ENTITY	The serotonin 5-HT2C receptor is a prominent serotonin receptor in basal ganglia : evidence from functional studies on serotonin-mediated phosphoinositide hydrolysis .
9326273	0	serotonin	45,54	5-HT2C	14,20	serotonin	5-HT2C	MESH:D012701	25187(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|nsubj|receptor receptor|nummod|END_ENTITY	The serotonin 5-HT2C receptor is a prominent serotonin receptor in basal ganglia : evidence from functional studies on serotonin-mediated phosphoinositide hydrolysis .
9844009	0	serotonin	36,45	5-HT2C_receptor	46,61	serotonin	5-HT2C receptor	MESH:D012701	15560(Tax:10090)	Chemical	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Perturbed dentate gyrus function in serotonin 5-HT2C_receptor mutant mice .
8151622	0	serotonin	48,57	5-HT2_receptor	58,72	serotonin	5-HT2 receptor	MESH:D012701	3356	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|amod|END_ENTITY	Development of a receptor-interaction model for serotonin 5-HT2_receptor antagonists .
22776473	0	serotonin	50,59	5-HT2b	75,81	serotonin	5-HT2b	MESH:D012701	3357	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Identification and expression analyses of a novel serotonin receptor gene , 5-HT2b , in the field cricket , Gryllus bimaculatus .
11594443	0	serotonin	16,25	5-HT2c	26,32	serotonin	5-HT2c	MESH:D012701	25187(Tax:10116)	Chemical	Gene	agonist|amod|START_ENTITY agonist|amod|END_ENTITY	Sertindole is a serotonin 5-HT2c inverse agonist and decreases agonist but not antagonist binding to 5-HT2c receptors after chronic treatment .
19058784	0	serotonin	10,19	5-HT2c	99,105	serotonin	5-HT2c	MESH:D012701	25187(Tax:10116)	Chemical	Gene	reuptake|compound|START_ENTITY inhibitors|nsubj|reuptake inhibitors|xcomp|modify modify|dobj|activities activities|nmod|receptor receptor|amod|END_ENTITY	Selective serotonin reuptake inhibitors modify physiological gastrointestinal motor activities via 5-HT2c receptor and acyl_ghrelin .
21281651	0	serotonin	39,48	5-HT2c	58,64	serotonin	5-HT2c	MESH:D012701	25187(Tax:10116)	Chemical	Gene	rhythm|nmod|START_ENTITY Control|nmod|rhythm Control|dep|role role|nmod|receptors receptors|amod|END_ENTITY	Control of hippocampal theta rhythm by serotonin : role of 5-HT2c receptors .
24562856	0	serotonin	89,98	5-HT2c	31,37	serotonin	5-HT2c	MESH:D012701	3358	Chemical	Gene	agonists|amod|START_ENTITY action|nmod|agonists Insights|nmod|action Insights|nmod|influence influence|nmod|variants variants|amod|END_ENTITY	Insights into the influence of 5-HT2c aminoacidic variants with the inhibitory action of serotonin inverse agonists and antagonists .
7700379	0	serotonin	52,61	5-HT2c	45,51	serotonin	5-HT2c	MESH:D012701	15560(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Eating_disorder and epilepsy in mice lacking 5-HT2c serotonin receptors .
11533135	0	serotonin	44,53	5-HT3A	37,43	serotonin	5-HT3A	MESH:D012701	15561(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|nummod|END_ENTITY	Open probability of homomeric murine 5-HT3A serotonin receptors depends on subunit occupancy .
1682951	0	serotonin	12,21	5-HT3_receptor	22,36	serotonin	5-HT3 receptor	MESH:D012701	79246(Tax:10116)	Chemical	Gene	antagonist|amod|START_ENTITY antagonist|amod|END_ENTITY	MDL72222 , a serotonin 5-HT3_receptor antagonist , blocks MDMA 's ability to establish a conditioned place preference .
7988681	0	serotonin	49,58	5-HT5A	42,48	serotonin	5-HT5A	MESH:D012701	25689(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|nummod|END_ENTITY	Cloning and characterisation of the human 5-HT5A serotonin receptor .
9602024	0	serotonin	27,36	5-HT5A	20,26	serotonin	5-HT5A	MESH:D012701	3361	Chemical	Gene	mRNA|compound|START_ENTITY mRNA|nummod|END_ENTITY	Distribution of the 5-HT5A serotonin receptor mRNA in the human brain .
8522988	0	serotonin	73,82	5-HT6	67,72	serotonin	5-HT6	MESH:D012701	3362	Chemical	Gene	receptor|compound|START_ENTITY receptor|nummod|END_ENTITY	Cloning , characterization , and chromosomal localization of a human 5-HT6 serotonin receptor .
12911615	0	serotonin	31,40	5-HTT	54,59	serotonin	5-HTT	MESH:D012701	6532	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Glucocorticoid-regulated human serotonin transporter -LRB- 5-HTT -RRB- expression is modulated by the 5-HTT gene-promotor-linked polymorphic region .
12911615	0	serotonin	31,40	5-HTT	92,97	serotonin	5-HTT	MESH:D012701	6532	Chemical	Gene	transporter|compound|START_ENTITY modulated|nsubjpass|transporter modulated|nmod|region region|amod|END_ENTITY	Glucocorticoid-regulated human serotonin transporter -LRB- 5-HTT -RRB- expression is modulated by the 5-HTT gene-promotor-linked polymorphic region .
17886257	0	serotonin	47,56	5-HTT	70,75	serotonin	5-HTT	MESH:D012701	6532	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Haplotype analysis confirms association of the serotonin transporter -LRB- 5-HTT -RRB- gene with schizophrenia but not with major_depression .
19429037	0	serotonin	47,56	5-HTT	70,75	serotonin	5-HTT	MESH:D012701	6532	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Haplotype analysis confirms association of the serotonin transporter -LRB- 5-HTT -RRB- gene with schizophrenia in the Han Chinese population .
19895335	0	serotonin	23,32	5-HTT	60,65	serotonin	5-HTT	MESH:D012701	6532	Chemical	Gene	promoter|amod|START_ENTITY study|nmod|promoter study|dep|gene gene|nummod|END_ENTITY	A prospective study of serotonin transporter gene promoter -LRB- 5-HTT gene linked polymorphic region -RRB- and intron 2 -LRB- variable number of tandem repeats -RRB- polymorphisms as predictors of trauma response to mild physical_injury .
24815315	0	serotonin	38,47	5-HTT	60,65	serotonin	5-HTT	MESH:D012701	6532	Chemical	Gene	tranporter|compound|START_ENTITY tranporter|appos|END_ENTITY	Endotoxaemia resulting from decreased serotonin tranporter -LRB- 5-HTT -RRB- function : A reciprocal risk factor for depression and insulin resistance ?
25524139	0	serotonin	11,20	5-HTT	34,39	serotonin	5-HTT	MESH:D012701	6532	Chemical	Gene	transporter|compound|START_ENTITY Changes|nmod|transporter Changes|appos|END_ENTITY	Changes in serotonin transporter -LRB- 5-HTT -RRB- gene expression in peripheral blood cells after MDMA intake .
8950411	0	serotonin	69,78	5-HTT	92,97	serotonin	5-HTT	MESH:D012701	6532	Chemical	Gene	region|nmod|START_ENTITY mutations|nmod|region screening|nmod|mutations transporter|nsubj|screening transporter|dep|END_ENTITY	Systematic screening for mutations in the coding region of the human serotonin transporter -LRB- 5-HTT -RRB- gene using PCR and DGGE .
9702741	0	serotonin	13,22	5-HTT	36,41	serotonin	5-HTT	MESH:D012701	6532	Chemical	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	A functional serotonin transporter -LRB- 5-HTT -RRB- polymorphism is associated with psychosis in neuroleptic-free_schizophrenics .
11121166	0	serotonin	46,55	5-HTTLPR	75,83	serotonin	5-HTTLPR	MESH:D012701	6532	Chemical	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Tardive_dyskinesia is not associated with the serotonin gene polymorphism -LRB- 5-HTTLPR -RRB- in Chinese .
12962916	0	serotonin	161,170	5-HTTLPR	228,236	serotonin	5-HTTLPR	MESH:D012701	6532	Chemical	Gene	concentration|compound|START_ENTITY independent|nsubj|concentration independent|nmod|variants variants|nummod|END_ENTITY	Despite the general correlation of the serotonin_transporter gene regulatory region polymorphism -LRB- 5-HTTLPR -RRB- and platelet serotonin concentration , lower platelet serotonin concentration in migraine patients is independent of the 5-HTTLPR variants .
12962916	0	serotonin	161,170	5-HTTLPR	98,106	serotonin	5-HTTLPR	MESH:D012701	6532	Chemical	Gene	concentration|compound|START_ENTITY independent|nsubj|concentration independent|nmod|correlation correlation|nmod|polymorphism polymorphism|appos|END_ENTITY	Despite the general correlation of the serotonin_transporter gene regulatory region polymorphism -LRB- 5-HTTLPR -RRB- and platelet serotonin concentration , lower platelet serotonin concentration in migraine patients is independent of the 5-HTTLPR variants .
15108187	0	serotonin	43,52	5-HTTLPR	88,96	serotonin	5-HTTLPR	MESH:D012701	6532	Chemical	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Meta-analysis of the association between a serotonin transporter promoter polymorphism -LRB- 5-HTTLPR -RRB- and anxiety-related_personality traits .
16362658	0	serotonin	11,20	5-HTTLPR	21,29	serotonin	5-HTTLPR	MESH:D012701	6532	Chemical	Gene	polymorphism|compound|START_ENTITY polymorphism|nummod|END_ENTITY	Functional serotonin 5-HTTLPR polymorphism is a risk factor for migraine_with_aura .
17146470	0	serotonin	104,113	5-HTTLPR	67,75	serotonin	5-HTTLPR	MESH:D012701	6532	Chemical	Gene	efficacy|compound|START_ENTITY association|nmod|efficacy association|dep|END_ENTITY	Meta-analysis of serotonin_transporter gene promoter polymorphism -LRB- 5-HTTLPR -RRB- association with selective serotonin reuptake inhibitor efficacy in depressed patients .
17450557	0	serotonin	27,36	5-HTTLPR	63,71	serotonin	5-HTTLPR	MESH:D012701	6532	Chemical	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	No interaction between the serotonin transporter polymorphism -LRB- 5-HTTLPR -RRB- and childhood adversity or recent stressful life events on symptoms of depression : results from two community surveys .
18164547	0	serotonin	32,41	5-HTTLPR	77,85	serotonin	5-HTTLPR	MESH:D012701	6532	Chemical	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Lack of association between the serotonin transporter promoter polymorphism -LRB- 5-HTTLPR -RRB- and personality traits in asymptomatic patients with panic_disorder .
18628680	0	serotonin	117,126	5-HTTLPR	17,25	serotonin	5-HTTLPR	MESH:D012701	6532	Chemical	Gene	reuptake|compound|START_ENTITY effect|nmod|reuptake gene|nmod|effect polymorphisms|nmod|gene polymorphisms|compound|END_ENTITY	The influence of 5-HTTLPR and STin2 polymorphisms in the serotonin_transporter gene on treatment effect of selective serotonin reuptake inhibitors in depressive patients .
19891962	0	serotonin	4,13	5-HTTLPR	49,57	serotonin	5-HTTLPR	MESH:D012701	6532	Chemical	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	The serotonin transporter promoter polymorphism -LRB- 5-HTTLPR -RRB- is associated with type 2 diabetes .
20096463	0	serotonin	7,16	5-HTTLPR	43,51	serotonin	5-HTTLPR	MESH:D012701	6532	Chemical	Gene	transporter|compound|START_ENTITY polymorphism|nsubj|transporter polymorphism|appos|END_ENTITY	Is the serotonin transporter polymorphism -LRB- 5-HTTLPR -RRB- a potential marker for suicidal behavior in bipolar_disorder patients ?
20640435	0	serotonin	48,57	5-HTTLPR	3,11	serotonin	5-HTTLPR	MESH:D012701	6532	Chemical	Gene	inhibitors|compound|START_ENTITY response|nmod|inhibitors linked|nmod|response linked|nsubjpass|END_ENTITY	Is 5-HTTLPR linked to the response of selective serotonin reuptake inhibitors in MDD ?
22086748	0	serotonin	4,13	5-HTTLPR	49,57	serotonin	5-HTTLPR	MESH:D012701	6532	Chemical	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	The serotonin transporter promoter polymorphism -LRB- 5-HTTLPR -RRB- affects the relation between antidepressant serum concentrations and effectiveness in major_depression .
22328412	0	serotonin	38,47	5-HTTLPR	78,86	serotonin	5-HTTLPR	MESH:D012701	6532	Chemical	Gene	variant|amod|START_ENTITY variant|appos|END_ENTITY	Moderation of adult depression by the serotonin transporter promoter variant -LRB- 5-HTTLPR -RRB- , childhood abuse and adult traumatic events in a general population sample .
22390669	0	serotonin	20,29	5-HTTLPR	56,64	serotonin	5-HTTLPR	MESH:D012701	6532	Chemical	Gene	polymorphism|compound|START_ENTITY polymorphism|appos|END_ENTITY	Interaction between serotonin transporter polymorphism -LRB- 5-HTTLPR -RRB- and stressful life events in adolescents ' trajectories of anxious/depressed symptoms .
22488255	0	serotonin	18,27	5-HTTLPR	54,62	serotonin	5-HTTLPR	MESH:D012701	6532	Chemical	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	The effect of the serotonin transporter polymorphism -LRB- 5-HTTLPR -RRB- on amygdala function : a meta-analysis .
23277128	0	serotonin	28,37	5-HTTLPR	61,69	serotonin	5-HTTLPR	MESH:D012701	6532	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|triallelic triallelic|dep|END_ENTITY	Study of the association of serotonin transporter triallelic 5-HTTLPR and STin2 VNTR polymorphisms with lithium prophylaxis response in bipolar_disorder .
23394411	0	serotonin	17,26	5-HTTLPR	58,66	serotonin	5-HTTLPR	MESH:D012701	6532	Chemical	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Association of a serotonin transporter gene polymorphism -LRB- 5-HTTLPR -RRB- and stressful_life_events with postpartum depressive_symptoms : a population-based study .
24105442	0	serotonin	22,31	5-HTTLPR	111,119	serotonin	5-HTTLPR	MESH:D012701	6532	Chemical	Gene	turnover|compound|START_ENTITY variation|nmod|turnover variation|nmod|END_ENTITY	Seasonal variation of serotonin turnover in human cerebrospinal fluid , depressive_symptoms and the role of the 5-HTTLPR .
24150247	0	serotonin	17,26	5-HTTLPR	155,163	serotonin	5-HTTLPR	MESH:D012701	6532	Chemical	Gene	homeostasis|nsubj|START_ENTITY predicts|csubj|homeostasis predicts|dobj|changes changes|dep|model model|acl|explain explain|nmod|phenotype phenotype|nmod|END_ENTITY	How the cerebral serotonin homeostasis predicts environmental changes : a model to explain seasonal changes of brain_5-HTT as intermediate phenotype of the 5-HTTLPR .
24637816	0	serotonin	19,28	5-HTTLPR	41,49	serotonin	5-HTTLPR	MESH:D012701	6532	Chemical	Gene	polymorphism|compound|START_ENTITY polymorphism|nummod|END_ENTITY	-LSB- The effect of the serotonin transporter 5-HTTLPR polymorphism on the recognition of facial_emotions in schizophrenia -RSB- .
25078292	0	serotonin	41,50	5-HTTLPR	81,89	serotonin	5-HTTLPR	MESH:D012701	6532	Chemical	Gene	interaction|nmod|START_ENTITY update|nmod|interaction transporter|nsubj|update transporter|dobj|variant variant|appos|END_ENTITY	An update on the interaction between the serotonin transporter promoter variant -LRB- 5-HTTLPR -RRB- , stress and depression , plus an exploration of non-confirming findings .
25128279	0	serotonin	36,45	5-HTTLPR	46,54	serotonin	5-HTTLPR	MESH:D012701	6532	Chemical	Gene	modulates|amod|START_ENTITY modulates|nummod|END_ENTITY	Functional genetic variation in the serotonin 5-HTTLPR modulates brain_damage in frontotemporal_dementia .
26886943	0	serotonin	43,52	5-HTTLPR	65,73	serotonin	5-HTTLPR	MESH:D012701	6532	Chemical	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	Meta-analysis of the association between a serotonin transporter 5-HTTLPR polymorphism and smoking cessation .
26896742	0	serotonin	27,36	5-HTTLPR	10,18	serotonin	5-HTTLPR	MESH:D012701	6532	Chemical	Gene	blockade|compound|START_ENTITY Impact|nmod|blockade Impact|nmod|END_ENTITY	Impact of 5-HTTLPR on SSRI serotonin transporter blockade during emotion regulation : A preliminary fMRI study .
8601462	0	serotonin	69,78	5-HTdro2B	59,68	serotonin	5-HTdro2B	MESH:D012701	37191(Tax:7227)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Functional characterisation of the Drosophila 5-HTdro1 and 5-HTdro2B serotonin receptors in insect cells : activation of a G -LRB- alpha -RRB- s-like protein by 5-HTdro1 but lack of coupling to inhibitory G-proteins by 5-HTdro2B .
11902118	0	serotonin	21,30	5-hT1A	53,59	serotonin	5-hT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|the the|nmod|PET PET|amod|END_ENTITY	Effect of endogenous serotonin on the binding of the 5-hT1A PET ligand 18F-MPPF in the rat hippocampus : kinetic beta measurements combined with microdialysis .
19103592	0	serotonin	82,91	5-hydroxytryptamine_2A	50,72	serotonin	5-hydroxytryptamine 2A	MESH:D012701	3356	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Ribosomal_S6_kinase_2 directly phosphorylates the 5-hydroxytryptamine_2A -LRB- 5-HT2A -RRB- serotonin receptor , thereby modulating 5-HT2A signaling .
11383553	0	serotonin	48,57	5HT-1a	58,64	serotonin	5HT-1a	MESH:D012701	24473(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Overcrowding induces anxiety and causes loss of serotonin 5HT-1a receptors in rats .
12724937	0	serotonin	64,73	5HT1A	75,80	serotonin	5HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Autoradiographic evaluation of electromagnetic field effects on serotonin -LRB- 5HT1A -RRB- receptors in rat brain .
16739558	3	serotonin	402,411	5HT1A	425,430	serotonin	5HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	agonists|amod|START_ENTITY agonists|nummod|END_ENTITY	Because systemic administration of serotonin 1A receptor -LRB- 5HT1A -RRB- agonists reversed the altered breathing patterns after spinal_cord_injury -LRB- SCI -RRB- , we predicted that 5HT1A receptor activation after SCI -LRB- C2 -RRB- would activate latent crossed motor pathways .
1829353	0	serotonin	19,28	5HT1A	70,75	serotonin	5HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	Depletion|nmod|START_ENTITY affects|nsubj|Depletion affects|dobj|behaviors behaviors|acl|induced induced|nmod|END_ENTITY	Depletion of brain serotonin differently affects behaviors induced by 5HT1A , 5HT1C , and 5HT2 receptor activation in rats .
20493020	0	serotonin	56,65	5HT1A	33,38	serotonin	5HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	sites|nmod|START_ENTITY sites|nummod|END_ENTITY	Evidence for the localization of 5HT1A binding sites on serotonin containing neurons in the raphe dorsalis and raphe centralis nuclei of the rat brain .
3941588	0	serotonin	26,35	5HT1A	78,83	serotonin	5HT1A	MESH:D012701	24473(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY fundus|nsubj|receptor evidence|dep|fundus END_ENTITY|nsubj|evidence	Further evidence that the serotonin receptor in the rat stomach fundus is not 5HT1A or 5HT1B .
7834355	0	serotonin	36,45	5HT1A	50,55	serotonin	5HT1A	MESH:D012701	3350	Chemical	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Localization and gene expression of serotonin 1A -LRB- 5HT1A -RRB- receptors in human brain postmortem .
8645269	0	serotonin	2,11	5HT1A	27,32	serotonin	5HT1A	MESH:D012701	3350	Chemical	Gene	variant|amod|START_ENTITY variant|appos|END_ENTITY	A serotonin receptor gene -LRB- 5HT1A -RRB- variant found in a Tourette 's _ syndrome patient .
1446239	0	serotonin	29,38	5HT1A_receptor	59,73	serotonin	5HT1A receptor	MESH:D012701	3350	Chemical	Gene	effects|nmod|START_ENTITY mediated|nsubjpass|effects mediated|nmod|END_ENTITY	The physiological effects of serotonin are mediated by the 5HT1A_receptor in the cat 's cerebellar cortex .
1557407	0	serotonin	12,21	5HT1B	6,11	serotonin	5HT1B	MESH:D012701	15551(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|nummod|END_ENTITY	Mouse 5HT1B serotonin receptor : cloning , functional expression , and localization in motor control centers .
1679849	0	serotonin	84,93	5HT1C	94,99	serotonin	5HT1C	MESH:D012701	25187(Tax:10116)	Chemical	Gene	agonist|compound|START_ENTITY agonist|nummod|END_ENTITY	-LRB- + -RRB- Lysergic_acid_diethylamide , but not its nonhallucinogenic congeners , is a potent serotonin 5HT1C receptor agonist .
1351684	0	serotonin	8,17	5HT1D_beta	39,49	serotonin	5HT1D beta	MESH:D012701	3351	Chemical	Gene	variant|compound|START_ENTITY variant|appos|END_ENTITY	A human serotonin 1D receptor variant -LRB- 5HT1D_beta -RRB- encoded by an intronless gene on chromosome 6 .
9050900	0	serotonin	18,27	5HT2C	12,17	serotonin	5HT2C	MESH:D012701	3358	Chemical	Gene	receptors|compound|START_ENTITY receptors|nummod|END_ENTITY	Blockage of 5HT2C serotonin receptors by fluoxetine -LRB- Prozac -RRB- .
10752491	0	serotonin	51,60	5HT3	46,50	serotonin	5HT3	MESH:D012701	3359	Chemical	Gene	antagonist|compound|START_ENTITY antagonist|nummod|END_ENTITY	Treatment of fibromyalgia with tropisetron , a 5HT3 serotonin antagonist : a pilot study .
16009349	0	serotonin	25,34	5HTT	48,52	serotonin	5HTT	MESH:D012701	6532	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Allelic variation in the serotonin transporter -LRB- 5HTT -RRB- gene contributes to idiopathic pulmonary_hypertension in children .
14990868	0	serotonin	117,126	5HTTLPR	162,169	serotonin	5HTTLPR	MESH:D012701	6532	Chemical	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Anxious behavior and fenfluramine-induced prolactin secretion in young rhesus_macaques with different alleles of the serotonin reuptake transporter polymorphism -LRB- 5HTTLPR -RRB- .
10557342	0	serotonin	60,69	CA1	99,102	serotonin	CA1	MESH:D012701	310218(Tax:10116)	Chemical	Gene	responses|compound|START_ENTITY responses|nmod|neurons neurons|compound|END_ENTITY	Long-term exposure to high corticosterone levels attenuates serotonin responses in rat hippocampal CA1 neurons .
18756498	0	serotonin	41,50	COMT	124,128	serotonin	COMT	MESH:D012701	1312	Chemical	Gene	region|amod|START_ENTITY region|appos|END_ENTITY	Interaction between gene variants of the serotonin transporter promoter region -LRB- 5-HTTLPR -RRB- and catechol_O-methyltransferase -LRB- COMT -RRB- in borderline_personality_disorder .
7064189	0	serotonin	4,13	CSF	0,3	serotonin	CSF	MESH:D012701	1437	Chemical	Gene	concentrations|compound|START_ENTITY concentrations|compound|END_ENTITY	CSF serotonin concentrations and cerebral arterial spasm in patients with ruptured_intracranial_aneurysm .
19755127	0	serotonin	67,76	CXCL12	11,17	serotonin	CXCL12	MESH:D012701	24772(Tax:10116)	Chemical	Gene	neurons|compound|START_ENTITY enhances|nmod|neurons enhances|nsubj|END_ENTITY	SDF-1alpha / CXCL12 enhances GABA and glutamate synaptic activity at serotonin neurons in the rat dorsal raphe nucleus .
10192756	0	serotonin	34,43	CYP2C9	14,20	serotonin	CYP2C9	MESH:D012701	1559	Chemical	Gene	inhibitors|compound|START_ENTITY END_ENTITY|nmod|inhibitors	Inhibition of CYP2C9 by selective serotonin reuptake inhibitors : in vitro studies with tolbutamide and -LRB- S -RRB- - warfarin using human liver microsomes .
9384467	0	serotonin	34,43	CYP2C9	14,20	serotonin	CYP2C9	MESH:D012701	1559	Chemical	Gene	inhibitors|compound|START_ENTITY END_ENTITY|nmod|inhibitors	Inhibition of CYP2C9 by selective serotonin reuptake inhibitors in vitro : studies of phenytoin p-hydroxylation .
17945210	0	serotonin	92,101	Corticotropin-releasing_factor	0,30	serotonin	Corticotropin-releasing factor	MESH:D012701	81648(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY affect|dobj|release affect|nsubj|1 1|amod|END_ENTITY	Corticotropin-releasing_factor 1 and 2 receptors in the dorsal raph differentially affect serotonin release in the nucleus accumbens .
18702701	0	serotonin	96,105	Corticotropin-releasing_factor	0,30	serotonin	Corticotropin-releasing factor	MESH:D012701	81648(Tax:10116)	Chemical	Gene	increases|dobj|START_ENTITY increases|nsubj|END_ENTITY	Corticotropin-releasing_factor in the dorsal raphe nucleus increases medial prefrontal cortical serotonin via type 2 receptors and median raphe nucleus activity .
19065121	0	serotonin	93,102	DTNBP1	16,22	serotonin	DTNBP1	MESH:D012701	84062	Chemical	Gene	inhibitors|compound|START_ENTITY response|nmod|inhibitors association|nmod|response gene|dep|association gene|appos|END_ENTITY	Dysbindin gene -LRB- DTNBP1 -RRB- in major_depression : association with clinical response to selective serotonin reuptake inhibitors .
20683774	0	serotonin	16,25	DTNBP1	66,72	serotonin	DTNBP1	MESH:D012701	84062	Chemical	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Polymorphism of serotonin receptor genes -LRB- 5-HTR2A -RRB- and Dysbindin -LRB- DTNBP1 -RRB- and individual components of short-term verbal memory processes in Schizophrenia .
6302223	1	serotonin	205,214	E1_and_E2	253,262	serotonin	E1 and E2	MESH:D012701	6080;6044	Chemical	Gene	effects|nmod|START_ENTITY mediating|dobj|effects mediating|nmod|END_ENTITY	The possible role of cyclic_AMP in mediating opposite modulatory effects of serotonin -LRB- 5-HT -RRB- on Aplysia buccal mass muscles E1_and_E2 was examined .
26903268	0	serotonin	29,38	ERICH3	8,14	serotonin	ERICH3	MESH:D012701	127254	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	TSPAN5 , ERICH3 and selective serotonin reuptake inhibitors in major_depressive_disorder : pharmacometabolomics-informed pharmacogenomics .
17597646	0	serotonin	51,60	FEV	68,71	serotonin	FEV	MESH:D012701	54738	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Sudden_infant_death_syndrome : rare mutation in the serotonin system FEV gene .
12445576	0	serotonin	35,44	Fos	61,64	serotonin	Fos	MESH:D012701	314322(Tax:10116)	Chemical	Gene	augmentation|compound|START_ENTITY augmentation|nmod|END_ENTITY	Effect of 5-HT1A receptor-mediated serotonin augmentation on Fos immunoreactivity in rat brain .
2323038	0	serotonin	36,45	GFAP	78,82	serotonin	GFAP	MESH:D012701	24387(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Neuron-glia interactions : effect of serotonin on the astroglial expression of GFAP and of its encoding message .
26009422	0	serotonin	11,20	GLP1	92,96	serotonin	GLP1	MESH:D012701	2641	Chemical	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Intestinal serotonin -LRB- 5-HT -RRB- signalling is hormonally regulated via glucagon-like_peptide_1 -LRB- GLP1 -RRB- and PKA/MAPK activation .
21820473	0	serotonin	18,27	Ghrelin	0,7	serotonin	Ghrelin	MESH:D012701	59301(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY inhibited|dobj|release inhibited|nsubj|END_ENTITY	Ghrelin inhibited serotonin release from hippocampal slices .
7566509	0	serotonin	15,24	GnRH	46,50	serotonin	GnRH	MESH:D012701	25194(Tax:10116)	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|regulation regulation|nmod|expression expression|compound|END_ENTITY	Involvement of serotonin in the regulation of GnRH gene expression in the male rat brain .
6839209	0	serotonin	26,35	Growth_hormone	0,14	serotonin	Growth hormone	MESH:D012701	403795(Tax:9615)	Chemical	Gene	secretion|compound|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Growth_hormone stimulates serotonin secretion into the hepatic portal circulation .
23195070	0	serotonin	25,34	HDAC2	93,98	serotonin	HDAC2	MESH:D012701	3066	Chemical	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|dep|role role|nmod|END_ENTITY	Regulation of intestinal serotonin transporter expression via epigenetic mechanisms : role of HDAC2 .
18163385	0	serotonin	30,39	HTR1A	53,58	serotonin	HTR1A	MESH:D012701	3350	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Association study between the serotonin 1A receptor -LRB- HTR1A -RRB- gene and neuroticism , major_depression , and anxiety_disorders .
21459095	0	serotonin	72,81	HTR1A	100,105	serotonin	HTR1A	MESH:D012701	3350	Chemical	Gene	receptor|compound|START_ENTITY receptor|dep|gene gene|appos|END_ENTITY	Predicting cortisol stress responses in older individuals : influence of serotonin receptor 1A gene -LRB- HTR1A -RRB- and stressful life events .
24432029	0	serotonin	21,30	HTR1A	44,49	serotonin	HTR1A	MESH:D012701	3350	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	The presence of both serotonin 1A receptor -LRB- HTR1A -RRB- and dopamine_transporter -LRB- DAT1 -RRB- gene variants increase the risk of borderline_personality_disorder .
11690602	0	serotonin	20,29	HTR1B	52,57	serotonin	HTR1B	MESH:D012701	3351	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Polymorphism of the serotonin 5-HT1B receptor gene -LRB- HTR1B -RRB- associated with minimum lifetime body mass index in women with bulimia_nervosa .
16344719	0	serotonin	41,50	HTR1B	64,69	serotonin	HTR1B	MESH:D012701	3351	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association analysis of polymorphisms in serotonin 1B receptor -LRB- HTR1B -RRB- gene with heroin_addiction : a comparison of molecular and statistically estimated haplotypes .
19350534	0	serotonin	32,41	HTR1B	60,65	serotonin	HTR1B	MESH:D012701	3351	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Functional polymorphisms in the serotonin 1B receptor gene -LRB- HTR1B -RRB- predict self-reported anger and hostility among young men .
23335468	0	serotonin	41,50	HTR1B	70,75	serotonin	HTR1B	MESH:D012701	3351	Chemical	Gene	_|appos|START_ENTITY Associations|nmod|_ _|nsubj|Associations _|dobj|gene gene|appos|END_ENTITY	Associations of the 5-hydroxytryptamine _ -LRB- serotonin -RRB- _ receptor_1B gene -LRB- HTR1B -RRB- with alcohol , cocaine , and heroin_abuse .
8001977	0	serotonin	43,52	HTR1E	75,80	serotonin	HTR1E	MESH:D012701	3354	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Assignment of the gene encoding the 5-HT1E serotonin receptor -LRB- S31 -RRB- -LRB- locus HTR1E -RRB- to human chromosome 6q14-q15 .
10754425	0	serotonin	10,19	HTR2	35,39	serotonin	HTR2	MESH:D012701	3356	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The human serotonin receptor gene -LRB- HTR2 -RRB- MspI polymorphism in Japanese schizophrenic and alcoholic patients .
1980030	0	serotonin	4,13	HTR2	39,43	serotonin	HTR2	MESH:D012701	3356	Chemical	Gene	receptor|compound|START_ENTITY subtype|nsubj|receptor subtype|dobj|locus locus|acl:relcl|genes genes|nsubj|END_ENTITY	The serotonin receptor subtype 2 locus HTR2 is on human chromosome 13 near genes for esterase_D and retinoblastoma-1 and on mouse chromosome 14 .
2032718	0	serotonin	16,25	HTR2	47,51	serotonin	HTR2	MESH:D012701	3356	Chemical	Gene	gene|amod|START_ENTITY Assignment|nmod|gene Assignment|appos|END_ENTITY	Assignment of a serotonin 5HT-2 receptor gene -LRB- HTR2 -RRB- to human chromosome 13q14-q21 and mouse chromosome 14 .
8672130	0	serotonin	29,38	HTR2	59,63	serotonin	HTR2	MESH:D012701	3356	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Syntenic assignment of human serotonin receptor subtype 2 -LRB- HTR2 -RRB- , esterase_D -LRB- ESD -RRB- , and fms-related tyrosine kinase -LRB- FLT -RRB- homologs to bovine chromosome 12 .
11032388	0	serotonin	17,26	HTR2A	27,32	serotonin	HTR2A	MESH:D012701	3356	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Evidence for the serotonin HTR2A receptor gene as a susceptibility factor in attention_deficit_hyperactivity_disorder -LRB- ADHD -RRB- .
15826503	0	serotonin	60,69	HTR2A	54,59	serotonin	HTR2A	MESH:D012701	3356	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	The association between the T102C polymorphism of the HTR2A serotonin receptor gene and HDL cholesterol level in Koreans .
18359159	0	serotonin	27,36	HTR2A	63,68	serotonin	HTR2A	MESH:D012701	3356	Chemical	Gene	subtypes|compound|START_ENTITY subtypes|appos|HTR3A HTR3A|dep|END_ENTITY	Relationship between three serotonin receptor subtypes -LRB- HTR3A , HTR2A and HTR4 -RRB- and treatment-resistant schizophrenia in the Japanese population .
19647026	0	serotonin	12,21	HTR2A	40,45	serotonin	HTR2A	MESH:D012701	3356	Chemical	Gene	gene|amod|START_ENTITY Analysis|nmod|gene Analysis|appos|END_ENTITY	Analysis of serotonin receptor 2A gene -LRB- HTR2A -RRB- : association study with autism_spectrum_disorder in the Indian population and investigation of the gene expression in peripheral blood leukocytes .
20047709	0	serotonin	38,47	HTR2A	21,26	serotonin	HTR2A	MESH:D012701	3356	Chemical	Gene	potential|amod|START_ENTITY influences|dobj|potential influences|nsubj|variation variation|nmod|END_ENTITY	Genetic variation in HTR2A influences serotonin transporter binding potential as measured using PET and -LSB- 11C -RSB- DASB .
20941551	0	serotonin	23,32	HTR2A	46,51	serotonin	HTR2A	MESH:D012701	3356	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Functional genomics of serotonin receptor 2A -LRB- HTR2A -RRB- : interaction of polymorphism , methylation , expression and disease association .
21598376	0	serotonin	23,32	HTR2A	56,61	serotonin	HTR2A	MESH:D012701	3356	Chemical	Gene	Gene|amod|START_ENTITY Gene|appos|END_ENTITY	Hypomethylation of the serotonin receptor type-2A Gene -LRB- HTR2A -RRB- at T102C polymorphic site in DNA derived from the saliva of patients with schizophrenia and bipolar_disorder .
21614492	0	serotonin	171,180	HTR2C	193,198	serotonin	HTR2C	MESH:D012701	3358	Chemical	Gene	receptor2C|compound|START_ENTITY receptor2C|appos|END_ENTITY	A candidate gene study of serotonergic pathway genes and pain relief during treatment with escitalopram in patients with neuropathic_pain shows significant association to serotonin receptor2C -LRB- HTR2C -RRB- .
24279860	6	serotonin	807,816	HTR2C	831,836	serotonin	MTHFR	MESH:D012701	4524	Chemical	Gene	START_ENTITY|nsubj|receptors receptors|appos|END_ENTITY	Among the steadiest findings associated with AIWG are serotonin 2C receptors -LRB- HTR2C -RRB- and leptin promoter gene variants , with more recent studies implicating MTHFR and , in particular , MC4R genes .
9034010	0	serotonin	15,24	HTR2C	8,13	serotonin	HTR2C	MESH:D012701	3358	Chemical	Gene	START_ENTITY|nsubj|5-HT2C 5-HT2C|appos|END_ENTITY	5-HT2C -LRB- HTR2C -RRB- serotonin receptor gene polymorphism associated with the human personality trait of reward dependence : interaction with dopamine_D4_receptor -LRB- D4DR -RRB- and dopamine_D3_receptor -LRB- D3DR -RRB- polymorphisms .
10206238	0	serotonin	52,61	HTR2c	78,83	serotonin	HTR2c	MESH:D012701	3358	Chemical	Gene	5HT2c|amod|START_ENTITY 5HT2c|appos|END_ENTITY	Allelic variants of dopamine_receptor_D4 -LRB- DRD4 -RRB- and serotonin receptor 5HT2c -LRB- HTR2c -RRB- and temperament factors : replication tests .
18359159	0	serotonin	27,36	HTR3A	56,61	serotonin	HTR3A	MESH:D012701	3359	Chemical	Gene	subtypes|compound|START_ENTITY subtypes|appos|END_ENTITY	Relationship between three serotonin receptor subtypes -LRB- HTR3A , HTR2A and HTR4 -RRB- and treatment-resistant schizophrenia in the Japanese population .
18807291	0	serotonin	23,32	HTR3B	51,56	serotonin	HTR3B	MESH:D012701	9177	Chemical	Gene	association|nmod|START_ENTITY receptor|nsubj|association receptor|dobj|gene gene|appos|END_ENTITY	An association between serotonin receptor 3B gene -LRB- HTR3B -RRB- and treatment-resistant_schizophrenia -LRB- TRS -RRB- in a Japanese population .
12898568	0	serotonin	34,43	HTR4	65,69	serotonin	HTR4	MESH:D012701	3360	Chemical	Gene	gene|amod|START_ENTITY haplotype|nmod|gene Association|nmod|haplotype Association|appos|END_ENTITY	Association of a haplotype in the serotonin 5-HT4 receptor gene -LRB- HTR4 -RRB- with Japanese schizophrenia .
9724925	0	serotonin	24,33	HTR4	51,55	serotonin	HTR4	MESH:D012701	3360	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Assignment of the human serotonin 4 receptor gene -LRB- HTR4 -RRB- to the long arm of chromosome 5 -LRB- 5q31-q33 -RRB- .
11163544	0	serotonin	42,51	HTR6	73,77	serotonin	HTR6	MESH:D012701	3362	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Lack of association between the T -- > C_267 serotonin 5-HT6 receptor gene -LRB- HTR6 -RRB- polymorphism and prediction of response to clozapine in schizophrenia .
10490701	0	serotonin	24,33	HTR7	57,61	serotonin	HTR7	MESH:D012701	3363	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Physical mapping of the serotonin 5-HT -LRB- 7 -RRB- receptor gene -LRB- HTR7 -RRB- to chromosome 10 and pseudogene -LRB- HTR7P -RRB- to chromosome 12 , and testing of linkage disequilibrium between HTR7 and autistic_disorder .
19233240	0	serotonin	24,33	HTR7	51,55	serotonin	HTR7	MESH:D012701	3363	Chemical	Gene	analysis|nmod|START_ENTITY receptor|nsubj|analysis receptor|dobj|gene gene|appos|END_ENTITY	Association analysis of serotonin receptor 7 gene -LRB- HTR7 -RRB- and risperidone response in Chinese schizophrenia patients .
23028768	0	serotonin	84,93	Htr1a	98,103	serotonin	Htr1a	MESH:D012701	15550(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Impaired chemosensitivity of mouse dorsal raphe serotonergic neurons overexpressing serotonin 1A -LRB- Htr1a -RRB- receptors .
8045595	0	serotonin	66,75	IL-3	31,35	serotonin	IL-3	MESH:D012701	16187(Tax:10090)	Chemical	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Interactions of IFN-gamma with IL-3 and IL-4 in the regulation of serotonin and arachidonate release from mouse peritoneal mast cells .
19019013	0	serotonin	25,34	IL1beta	0,7	serotonin	IL1beta	MESH:D012701	3553	Chemical	Gene	secretion|compound|START_ENTITY secretion|amod|END_ENTITY	IL1beta - and LPS-induced serotonin secretion is increased in EC cells derived from Crohn 's _ disease .
1915558	0	serotonin	26,35	Interferon-gamma	0,16	serotonin	Interferon-gamma	MESH:D012701	15978(Tax:10090)	Chemical	Gene	release|compound|START_ENTITY inhibits|dobj|release inhibits|nsubj|END_ENTITY	Interferon-gamma inhibits serotonin release from mouse peritoneal mast cells .
20093369	0	serotonin	40,49	Jab1	24,28	serotonin	Jab1	MESH:D012701	10987	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Physical interaction of Jab1 with human serotonin 6 G-protein-coupled receptor and their possible roles in cell survival .
24650663	0	serotonin	11,20	LR11	69,73	serotonin	LR11	MESH:D012701	6653	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of serotonin on expression of the LDL receptor family member LR11 and 7-ketocholesterol-induced apoptosis in human vascular smooth muscle cells .
10510338	0	serotonin	17,26	Leptin	0,6	serotonin	Leptin	MESH:D012701	16846(Tax:10090)	Chemical	Gene	turnover|compound|START_ENTITY increases|dobj|turnover increases|nsubj|END_ENTITY	Leptin increases serotonin turnover by inhibition of brain nitric_oxide synthesis .
20211152	0	serotonin	96,105	Leptin	0,6	serotonin	Leptin	MESH:D012701	25608(Tax:10116)	Chemical	Gene	content|compound|START_ENTITY correlated|nmod|content correlated|nsubjpass|accumulation accumulation|compound|END_ENTITY	Leptin accumulation in hypothalamic and dorsal raphe neurons is inversely correlated with brain serotonin content .
21531340	0	serotonin	36,45	Leptin	0,6	serotonin	Leptin	MESH:D012701	16846(Tax:10090)	Chemical	Gene	neurons|compound|START_ENTITY affect|dobj|neurons affect|nsubj|END_ENTITY	Leptin does not directly affect CNS serotonin neurons to influence appetite .
16042979	0	serotonin	8,17	NPY	82,85	serotonin	NPY	MESH:D012701	109648(Tax:10090)	Chemical	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of serotonin -LRB- 5-HT -RRB- in the antidepressant-like properties of neuropeptide_Y -LRB- NPY -RRB- in the mouse forced swim test .
8234027	0	serotonin	152,161	NPY	136,139	serotonin	NPY	MESH:D012701	24604(Tax:10116)	Chemical	Gene	effects|nmod:poss|START_ENTITY mediate|dobj|effects mediate|nsubj|END_ENTITY	Increased neuropeptide Y concentrations in specific hypothalamic nuclei of the rat following treatment with methysergide : evidence that NPY may mediate serotonin 's effects on food intake .
8358162	0	serotonin	35,44	NPY	65,68	serotonin	NPY	MESH:D012701	109648(Tax:10090)	Chemical	Gene	distribution|nmod|START_ENTITY distribution|appos|END_ENTITY	Immunocytochemical distribution of serotonin and neuropeptide_Y -LRB- NPY -RRB- in mouse adrenal gland .
8899812	0	serotonin	168,177	NPY	152,155	serotonin	NPY	MESH:D012701	24604(Tax:10116)	Chemical	Gene	effects|nmod:poss|START_ENTITY mediate|dobj|effects mediate|nsubj|END_ENTITY	Differential effects of the 5-HT 1B/2C receptor agonist mCPP and the 5-HT1A agonist flesinoxan on hypothalamic neuropeptide Y in the rat : evidence that NPY may mediate serotonin 's effects on food intake .
20871394	0	serotonin	23,32	Neurokinin-1	0,12	serotonin	Neurokinin-1	MESH:D012701	6863	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|amod|END_ENTITY	Neurokinin-1 and novel serotonin antagonists for postoperative and postdischarge_nausea_and_vomiting .
9765360	0	serotonin	32,41	Oxytocin	0,8	serotonin	Oxytocin	MESH:D012701	18429(Tax:10090)	Chemical	Gene	uptake|nmod|START_ENTITY inhibits|dobj|uptake inhibits|nsubj|END_ENTITY	Oxytocin inhibits the uptake of serotonin into uterine mast cells .
20717101	0	serotonin	52,61	PPARy	21,26	serotonin	PPARy	MESH:D012701	5468	Chemical	Gene	responds|nmod|START_ENTITY responds|nsubj|END_ENTITY	The nuclear receptor PPARy individually responds to serotonin - and fatty_acid-metabolites .
12682061	0	serotonin	43,52	PSD-95	24,30	serotonin	PSD-95	MESH:D012701	1742	Chemical	Gene	receptors|compound|START_ENTITY END_ENTITY|nmod|receptors	A direct interaction of PSD-95 with 5-HT2A serotonin receptors regulates receptor trafficking and signal transduction .
16914526	0	serotonin	52,61	PSD-95	20,26	serotonin	PSD-95	MESH:D012701	1742	Chemical	Gene	desensitization|amod|START_ENTITY effects|nmod|desensitization effects|nmod|proteins proteins|compound|END_ENTITY	Opposite effects of PSD-95 and MPP3 PDZ proteins on serotonin 5-hydroxytryptamine2C receptor desensitization and membrane stability .
19494135	0	serotonin	80,89	PSD-95	0,6	serotonin	PSD-95	MESH:D012701	13385(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY actions|nmod|receptors essential|nmod|actions essential|nsubj|END_ENTITY	PSD-95 is essential for hallucinogen and atypical antipsychotic drug actions at serotonin receptors .
3517149	0	serotonin	32,41	PYY	62,65	serotonin	PYY	MESH:D012701	5697	Chemical	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Ultrastructural localization of serotonin and polypeptide_YY -LRB- PYY -RRB- in endocrine cells of the human rectum .
10023505	0	serotonin	89,98	Prolactin	0,9	serotonin	Prolactin	MESH:D012701	5617	Chemical	Gene	inhibitors|amod|START_ENTITY d-fenfluramine|nmod|inhibitors d-fenfluramine|nsubj|response response|compound|END_ENTITY	Prolactin response to d-fenfluramine in major_depression before and after treatment with serotonin reuptake inhibitors .
6235145	0	serotonin	125,134	Prolactin	0,9	serotonin	Prolactin	MESH:D012701	100303694(Tax:9103)	Chemical	Gene	administration|nmod|START_ENTITY levels|nmod|administration levels|amod|END_ENTITY	Prolactin and luteinizing hormone levels of prelaying , laying and postlaying turkey hens following central administration of serotonin and peripheral administration of quipazine_maleate .
662080	0	serotonin	25,34	Prolactin	0,9	serotonin	Prolactin	MESH:D012701	5617	Chemical	Gene	antagonists|compound|START_ENTITY suppression|nmod|antagonists suppression|compound|END_ENTITY	Prolactin suppression by serotonin antagonists in man : further evidence for serotoninergic control of prolactin secretion .
8894606	0	serotonin	53,62	Prolactin	0,9	serotonin	Prolactin	MESH:D012701	24683(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY independent|nmod|release independent|nsubj|response response|compound|END_ENTITY	Prolactin response to fenfluramine is independent of serotonin release .
17220354	0	serotonin	15,24	RGS4	0,4	serotonin	RGS4	MESH:D012701	29480(Tax:10116)	Chemical	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	RGS4 modulates serotonin signaling in prefrontal cortex and links_to_serotonin_dysfunction in a rat model of schizophrenia .
19786426	0	serotonin	67,76	S100B	9,14	serotonin	S100B	MESH:D012701	6285	Chemical	Gene	inhibitors|compound|START_ENTITY END_ENTITY|nmod|inhibitors	Neonatal S100B protein levels after prenatal exposure to selective serotonin reuptake inhibitors .
26499172	0	serotonin	25,34	S100B	0,5	serotonin	S100B	MESH:D012701	20203(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY interacts|nmod|receptor interacts|nsubj|END_ENTITY	S100B interacts with the serotonin 5-HT7 receptor to regulate a depressive-like behavior .
1513320	0	serotonin	53,62	S31	11,14	serotonin	S31	MESH:D012701	3354	Chemical	Gene	receptor|amod|START_ENTITY defined|dobj|receptor pharmacologically|acl|defined encodes|dobj|pharmacologically encodes|nsubj|END_ENTITY	Human gene S31 encodes the pharmacologically defined serotonin 5-hydroxytryptamine1E receptor .
1733778	0	serotonin	57,66	S31	35,38	serotonin	S31	MESH:D012701	3354	Chemical	Gene	receptor|compound|START_ENTITY encoding|dobj|receptor cloning|acl|encoding cloning|nmod|gene gene|appos|END_ENTITY	Molecular cloning of a human gene -LRB- S31 -RRB- encoding a novel serotonin receptor mediating inhibition of adenylyl cyclase .
8001977	0	serotonin	43,52	S31	63,66	serotonin	S31	MESH:D012701	3354	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Assignment of the gene encoding the 5-HT1E serotonin receptor -LRB- S31 -RRB- -LRB- locus HTR1E -RRB- to human chromosome 6q14-q15 .
8450834	0	serotonin	10,19	S31	6,9	serotonin	S31	MESH:D012701	3354	Chemical	Gene	clone|compound|START_ENTITY clone|compound|END_ENTITY	Human S31 serotonin receptor clone encodes a 5-hydroxytryptamine1E-like serotonin receptor .
8450834	0	serotonin	72,81	S31	6,9	serotonin	S31	MESH:D012701	3354	Chemical	Gene	receptor|compound|START_ENTITY encodes|dobj|receptor encodes|nsubj|clone clone|compound|END_ENTITY	Human S31 serotonin receptor clone encodes a 5-hydroxytryptamine1E-like serotonin receptor .
1257610	0	serotonin	66,75	SBP	34,37	serotonin	SBP	MESH:D012701	8991	Chemical	Gene	protein|nmod|START_ENTITY protein|appos|END_ENTITY	Is the serotonin binding protein -LRB- SBP -RRB- a soluble storage form for serotonin ?
23755541	0	serotonin	30,39	SER-4	24,29	serotonin	SER-4	MESH:D012701	175322(Tax:6239)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	-LSB- On the role of gene of SER-4 serotonin receptor in thermotolerance of Caenorhabditis_elegans behavior -RSB- .
12682218	0	serotonin	10,19	SERT	157,161	serotonin	SERT	MESH:D012701	6532	Chemical	Gene	cells|amod|START_ENTITY Uptake|nmod|cells occurs|nsubj|Uptake occurs|nmod|serotonin_transporter serotonin_transporter|appos|END_ENTITY	Uptake of serotonin at the apical and basolateral membranes of human intestinal epithelial -LRB- Caco-2 -RRB- cells occurs through the neuronal serotonin_transporter -LRB- SERT -RRB- .
16472867	0	serotonin	66,75	SERT	121,125	serotonin	SERT	MESH:D012701	15567(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY analysis|nmod|uptake synaptosomes|nmod|analysis synaptosomes|dobj|comparison comparison|nmod|chronoamperometry chronoamperometry|nmod|mice mice|amod|END_ENTITY	Filtration disrupts synaptosomes during radiochemical analysis of serotonin uptake : comparison with chronoamperometry in SERT knockout mice .
18712364	0	serotonin	83,92	SERT	126,130	serotonin	SERT	MESH:D012701	15567(Tax:10090)	Chemical	Gene	levels|compound|START_ENTITY levels|nmod|serotonin_transporter serotonin_transporter|appos|END_ENTITY	Neurochemical , behavioral , and physiological effects of pharmacologically enhanced serotonin levels in serotonin_transporter -LRB- SERT -RRB- - deficient mice .
18980809	1	serotonin	185,194	SERT	208,212	serotonin	SERT	MESH:D012701	15567(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|dep|/ /|compound|END_ENTITY	Our previous studies have demonstrated that mice with reduced or absent serotonin transporter -LRB- SERT + / - and SERT - / - mice , respectively -RRB- are more sensitive to stress relative to their SERT normal littermates -LRB- SERT + / + mice -RRB- .
19323988	0	serotonin	18,27	SERT	40,44	serotonin	SERT	MESH:D012701	282365(Tax:9913)	Chemical	Gene	transporter|compound|START_ENTITY Expression|nmod|transporter END_ENTITY|nsubj|Expression	Expression of the serotonin transporter SERT in the genital tract of cattle .
19946177	4	serotonin	804,813	SERT	851,855	serotonin	SERT	MESH:D012701	6532	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	To further elucidate the role of the C-terminus of SERT , we investigated whether overexpression of FLAG-tagged SERT C-terminus -LRB- FLAG-SERT-CT -RRB- affected the serotonin uptake activity and glycosylation of SERT .
20729489	0	serotonin	64,73	SERT	24,28	serotonin	SERT	MESH:D012701	6532	Chemical	Gene	levels|compound|START_ENTITY regulation|nmod|levels mechanisms|dep|regulation mechanisms|nmod|END_ENTITY	Molecular mechanisms of SERT in platelets : regulation of plasma serotonin levels .
21919867	0	serotonin	67,76	SERT	90,94	serotonin	SERT	MESH:D012701	15567(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	An activity model for novel antidepressants that interact with the serotonin transporter -LRB- SERT -RRB- .
23618227	3	serotonin	498,507	SERT	522,526	serotonin	SERT	MESH:D012701	6532	Chemical	Gene	transporters|compound|START_ENTITY transporters|appos|END_ENTITY	In the present study , we aimed to develop a method to visualize serotonin transporters -LRB- SERT -RRB- in the hypothalamus .
24013013	0	serotonin	160,169	SERT	183,187	serotonin	SERT	MESH:D012701	15567(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Reappraisal of spontaneous stereotypy in the deer mouse as an animal model of obsessive-compulsive_disorder -LRB- OCD -RRB- : response to escitalopram treatment and basal serotonin transporter -LRB- SERT -RRB- density .
25261781	0	serotonin	70,79	SERT	95,99	serotonin	SERT	MESH:D012701	15567(Tax:10090)	Chemical	Gene	control|nmod|START_ENTITY neurons|nsubj|control neurons|nmod|mouse mouse|compound|END_ENTITY	Enhanced 5-HT1A_receptor-dependent feedback control over dorsal raphe serotonin neurons in the SERT knockout mouse .
10640694	0	serotonin	35,44	SET	72,75	serotonin	SET	MESH:D012701	25553(Tax:10116)	Chemical	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunocytochemical localization of serotonin and serotonin_transporter -LRB- SET -RRB- in taste buds of rat .
10898918	0	serotonin	39,48	SLC6A4	75,81	serotonin	SLC6A4	MESH:D012701	6532	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Lack of linkage disequilibrium between serotonin transporter protein gene -LRB- SLC6A4 -RRB- and bipolar_disorder .
17519929	0	serotonin	128,137	SLC6A4	30,36	serotonin	SLC6A4	MESH:D012701	6532	Chemical	Gene	associated|xcomp|START_ENTITY associated|nsubjpass|serotonin_transporter serotonin_transporter|appos|END_ENTITY	Infant serotonin_transporter -LRB- SLC6A4 -RRB- promoter genotype is associated with adverse neonatal outcomes after prenatal exposure to serotonin reuptake inhibitor medications .
18824000	0	serotonin	178,187	SLC6A4	96,102	serotonin	SLC6A4	MESH:D012701	6532	Chemical	Gene	systems|compound|START_ENTITY influence|dobj|systems related|ccomp|influence related|nmod|END_ENTITY	How the serotonin story is being rewritten by new gene-based discoveries principally related to SLC6A4 , the serotonin_transporter gene , which functions to influence all cellular serotonin systems .
18824000	0	serotonin	8,17	SLC6A4	96,102	serotonin	SLC6A4	MESH:D012701	6532	Chemical	Gene	story|compound|START_ENTITY rewritten|nsubjpass|story related|csubj|rewritten related|nmod|END_ENTITY	How the serotonin story is being rewritten by new gene-based discoveries principally related to SLC6A4 , the serotonin_transporter gene , which functions to influence all cellular serotonin systems .
18983505	0	serotonin	24,33	SLC6A4	102,108	serotonin	SLC6A4	MESH:D012701	6532	Chemical	Gene	paroxetine|amod|START_ENTITY Effect|nmod|paroxetine modified|nsubjpass|Effect modified|nmod|polymorphism polymorphism|compound|END_ENTITY	Effect of the selective serotonin reuptake inhibitor paroxetine on platelet function is modified by a SLC6A4 serotonin_transporter polymorphism .
20439795	0	serotonin	76,85	SLC6A4	117,123	serotonin	SLC6A4	MESH:D012701	6532	Chemical	Gene	genotype|amod|START_ENTITY genotype|appos|END_ENTITY	Prenatal effects of selective serotonin reuptake inhibitor antidepressants , serotonin transporter promoter genotype -LRB- SLC6A4 -RRB- , and maternal mood on child behavior at 3 years of age .
22745770	0	serotonin	85,94	SLC6A4	11,17	serotonin	SLC6A4	MESH:D012701	6532	Chemical	Gene	synthesis|compound|START_ENTITY measures|nmod|synthesis associated|nmod|measures associated|nsubjpass|methylation methylation|compound|END_ENTITY	Peripheral SLC6A4 DNA methylation is associated with in vivo measures of human brain serotonin synthesis and childhood physical aggression .
24130516	0	serotonin	72,81	SLC6A4	113,119	serotonin	SLC6A4	MESH:D012701	6532	Chemical	Gene	functions|compound|START_ENTITY functions|appos|END_ENTITY	Prenatal serotonin reuptake inhibitor -LRB- SRI -RRB- antidepressant exposure and serotonin transporter promoter genotype -LRB- SLC6A4 -RRB- influence executive functions at 6 years of age .
19771307	0	serotonin	66,75	Serotonin_transporter	0,21	serotonin	Serotonin transporter	MESH:D012701	6532	Chemical	Gene	polymorphism|nmod|START_ENTITY polymorphism|amod|END_ENTITY	Serotonin_transporter gene polymorphism and treatment response to serotonin reuptake inhibitor -LRB- escitalopram -RRB- in depression : An open pilot study .
6110467	0	serotonin	29,38	Somatostatin	0,12	serotonin	Somatostatin	MESH:D012701	24797(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY facilitates|dobj|release facilitates|nsubj|END_ENTITY	Somatostatin facilitates the serotonin release from rat cerebral cortex , hippocampus and hypothalamus slices .
21325831	0	serotonin	14,23	Syk	72,75	serotonin	Syk	MESH:D012701	6850	Chemical	Gene	transport|compound|START_ENTITY Regulation|nmod|transport Regulation|nmod|END_ENTITY	Regulation of serotonin transport in human platelets by tyrosine kinase Syk .
2741308	0	serotonin	101,110	T-2	57,60	serotonin	T-2	MESH:D012701	681288(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Acute and chronic effects of the trichothecene mycotoxin T-2 on rat brain regional concentrations of serotonin , tryptophan , and tyrosine .
7508641	0	serotonin	75,84	TRH	87,90	serotonin	TRH	MESH:D012701	25569(Tax:10116)	Chemical	Gene	-|compound|START_ENTITY -|appos|END_ENTITY	The serotoninergic bulbospinal system and brainstem-spinal cord content of serotonin - , _ TRH - , and substance P-like immunoreactivity in the aged rat with special reference to the spinal cord motor nucleus .
2441808	0	serotonin	63,72	Thyrotropin-releasing_hormone	0,29	serotonin	Thyrotropin-releasing hormone	MESH:D012701	25569(Tax:10116)	Chemical	Gene	coexistence|nmod|START_ENTITY apposing|amod|coexistence END_ENTITY|dep|apposing	Thyrotropin-releasing_hormone in spinal cord : coexistence with serotonin and with substance P in fibers and terminals apposing identified preganglionic sympathetic neurons .
3930219	0	serotonin	73,82	Thyrotropin-releasing_hormone	0,29	serotonin	Thyrotropin-releasing hormone	MESH:D012701	25569(Tax:10116)	Chemical	Gene	stimulated|nmod|START_ENTITY stimulated|nsubjpass|release release|amod|END_ENTITY	Thyrotropin-releasing_hormone release from rat pancreas is stimulated by serotonin but inhibited by carbachol .
7812785	0	serotonin	99,108	Thyrotropin-releasing_hormone	0,29	serotonin	Thyrotropin-releasing hormone	MESH:D012701	25569(Tax:10116)	Chemical	Gene	reverses|nmod|START_ENTITY reverses|nsubj|END_ENTITY	Thyrotropin-releasing_hormone reverses the supersensitively depressed monosynaptic transmission by serotonin in 5,7-dihydroxytryptamine-treated neonatal rats in vitro .
12018774	0	serotonin	112,121	Tyrosine_hydroxylase	0,20	serotonin	Tyrosine hydroxylase	MESH:D012701	25085(Tax:10116)	Chemical	Gene	afferents|compound|START_ENTITY influence|nmod|afferents expression|dep|influence expression|amod|END_ENTITY	Tyrosine_hydroxylase expression in differentiating neurons of the rat arcuate nucleus : stimulatory influence of serotonin afferents .
2419520	0	serotonin	42,51	VIP	0,3	serotonin	VIP	MESH:D012701	117064(Tax:10116)	Chemical	Gene	afferents|compound|START_ENTITY targets|nmod|afferents neurons|nmod|targets neurons|nsubj|END_ENTITY	VIP neurons as prime synaptic targets for serotonin afferents in rat suprachiasmatic nucleus : a combined radioautographic and immunocytochemical study .
3872804	0	serotonin	101,110	VIP	62,65	serotonin	VIP	MESH:D012701	117064(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Inhibition Inhibition|nmod|antiserum antiserum|appos|END_ENTITY	Inhibition by antiserum to vasoactive_intestinal_polypeptide -LRB- VIP -RRB- of prolactin secretion induced by serotonin in the rat .
6655494	0	serotonin	53,62	VIP	45,48	serotonin	VIP	MESH:D012701	117064(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY Modulation|nmod|receptors Modulation|appos|END_ENTITY	Modulation by vasoactive intestinal peptide -LRB- VIP -RRB- of serotonin receptors in membranes from rat hippocampus .
6709640	0	serotonin	102,111	VIP	63,66	serotonin	VIP	MESH:D012701	117064(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Involvement Involvement|nmod|vasoactive_intestinal_polypeptide vasoactive_intestinal_polypeptide|appos|END_ENTITY	Involvement of hypothalamic vasoactive_intestinal_polypeptide -LRB- VIP -RRB- in prolactin secretion induced by serotonin in rats .
9756504	0	serotonin	44,53	VIP	10,13	serotonin	VIP	MESH:D012701	117064(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY Effect|nmod|release Effect|nmod|END_ENTITY	Effect of VIP and PACAP on basal release of serotonin from isolated vascularly and luminally perfused rat duodenum .
9928058	0	serotonin	59,68	VIP	10,13	serotonin	VIP	MESH:D012701	117064(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of VIP and PACAP on vascular and luminal release of serotonin from isolated perfused rat duodenum .
8891297	0	serotonin	21,30	adenosine_A2a_receptor	34,56	serotonin	adenosine A2a receptor	MESH:D012701	25369(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Augmented release of serotonin by adenosine_A2a_receptor activation and desensitization by CGS_21680 in the rat nucleus tractus solitarius .
2549146	0	serotonin	10,19	alpha-melanocyte-stimulating_hormone	23,59	serotonin	alpha-melanocyte-stimulating hormone	MESH:D012701	5443	Chemical	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	Effect of serotonin on alpha-melanocyte-stimulating_hormone secretion from perifused frog neurointermediate lobe : evidence for the presence of serotonin-containing cells in the frog pars intermedia .
2557964	0	serotonin	105,114	alpha-melanocyte-stimulating_hormone	14,50	serotonin	alpha-melanocyte-stimulating hormone	MESH:D012701	24664(Tax:10116)	Chemical	Gene	hypothalamus|nmod|START_ENTITY hypothalamus|nsubj|Regulation Regulation|nmod|release release|amod|END_ENTITY	Regulation of alpha-melanocyte-stimulating_hormone release from superfused slices of rat hypothalamus by serotonin and the interaction of serotonin with the dopaminergic system inhibiting peptide release .
2845440	0	serotonin	103,112	alpha-melanocyte_stimulating_hormone	21,57	serotonin	alpha-melanocyte stimulating hormone	MESH:D012701	24664(Tax:10116)	Chemical	Gene	involvement|nmod|START_ENTITY action|dep|involvement action|nmod|END_ENTITY	Inhibitory action of alpha-melanocyte_stimulating_hormone on lordosis in rats : possible involvement of serotonin .
15140561	0	serotonin	72,81	androgen_receptor	51,68	serotonin	androgen receptor	MESH:D012701	24208(Tax:10116)	Chemical	Gene	neurons|compound|START_ENTITY END_ENTITY|nmod|neurons	Expression of estrogen receptors -LRB- alpha , beta -RRB- and androgen_receptor in serotonin neurons of the rat and mouse dorsal raphe nuclei ; sex and species differences .
6311519	0	serotonin	52,61	angiotensin_II	11,25	serotonin	angiotensin II	MESH:D012701	24179(Tax:10116)	Chemical	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of angiotensin_II , K + , adrenocorticotropin , serotonin , adenosine 3 ' ,5 ' - monophosphate , guanosine 3 ' ,5 ' - monophosphate , A23187 , and EGTA on aldosterone synthesis and phospholipid metabolism in the rat adrenal zona glomerulosa .
9630554	0	serotonin	69,78	arylalkylamine_N-acetyltransferase	79,113	serotonin	arylalkylamine N-acetyltransferase	MESH:D012701	15	Chemical	Gene	START_ENTITY|dobj|activity activity|amod|END_ENTITY	Inhibitors of messenger RNA and protein synthesis affect differently serotonin arylalkylamine_N-acetyltransferase activity in clock-controlled and non clock-controlled fish pineal .
21732322	0	serotonin	37,46	b-lactoglobulin	16,31	serotonin	b-lactoglobulin	MESH:D012701	280838(Tax:9913)	Chemical	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of b-lactoglobulin with serotonin and arachidonyl_serotonin .
18474368	0	serotonin	57,66	brain-derived_neurotrophic_factor	13,46	serotonin	brain-derived neurotrophic factor	MESH:D012701	24225(Tax:10116)	Chemical	Gene	neurotransmission|compound|START_ENTITY Influence|nmod|neurotransmission Influence|nmod|END_ENTITY	Influence of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- on serotonin neurotransmission in the hippocampus of adult rodents .
19568484	0	serotonin	73,82	brain-derived_neurotrophic_factor	6,39	serotonin	brain-derived neurotrophic factor	MESH:D012701	627	Chemical	Gene	system|compound|START_ENTITY indicators|nmod|system indicators|amod|END_ENTITY	Serum brain-derived_neurotrophic_factor and peripheral indicators of the serotonin system in underweight and weight-recovered adolescent girls and women with anorexia_nervosa .
21338649	0	serotonin	137,146	brain-derived_neurotrophic_factor	4,37	serotonin	brain-derived neurotrophic factor	MESH:D012701	627	Chemical	Gene	inhibitors|compound|START_ENTITY associated|nmod|inhibitors polymorphism|ccomp|associated polymorphism|nsubj|END_ENTITY	The brain-derived_neurotrophic_factor -LRB- BDNF -RRB- polymorphism Val66Met is associated with neither serum BDNF level nor response to selective serotonin reuptake inhibitors in depressed Japanese patients .
22139606	0	serotonin	149,158	brain-derived_neurotrophic_factor	30,63	serotonin	brain-derived neurotrophic factor	MESH:D012701	24225(Tax:10116)	Chemical	Gene	involvement|nmod|START_ENTITY injection|dep|involvement injection|nmod|increases increases|amod|END_ENTITY	Intrahippocampal injection of brain-derived_neurotrophic_factor increases anxiety-related , but not panic-related defensive responses : involvement of serotonin .
22531372	0	serotonin	85,94	brain-derived_neurotrophic_factor	10,43	serotonin	brain-derived neurotrophic factor	MESH:D012701	12064(Tax:10090)	Chemical	Gene	system|compound|START_ENTITY Effect|nmod|system Effect|nmod|END_ENTITY	Effect of brain-derived_neurotrophic_factor on behavior and key members of the brain serotonin system in genetically predisposed to behavioral_disorders mouse_strains .
22917617	0	serotonin	73,82	brain-derived_neurotrophic_factor	18,51	serotonin	brain-derived neurotrophic factor	MESH:D012701	12064(Tax:10090)	Chemical	Gene	transmission|compound|START_ENTITY regulation|nmod|transmission role|nmod|regulation role|nmod|END_ENTITY	Essential role of brain-derived_neurotrophic_factor in the regulation of serotonin transmission in the basolateral amygdala .
26100147	0	serotonin	96,105	brain-derived_neurotrophic_factor	10,43	serotonin	brain-derived neurotrophic factor	MESH:D012701	12064(Tax:10090)	Chemical	Gene	lacking|dobj|START_ENTITY mice|acl|lacking concentrations|nmod|mice END_ENTITY|dep|concentrations	Increased brain-derived_neurotrophic_factor -LRB- BDNF -RRB- protein concentrations in mice lacking brain serotonin .
26899501	0	serotonin	97,106	brain-derived_neurotrophic_factor	14,47	serotonin	brain-derived neurotrophic factor	MESH:D012701	627	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- and its precursor proBDNF in the brain by serotonin .
8964090	0	serotonin	51,60	calmodulin	5,15	serotonin	calmodulin	MESH:D012701	808	Chemical	Gene	transport|compound|START_ENTITY regulation|nmod|transport regulation|compound|END_ENTITY	Ca2 + / calmodulin and protein_kinase_C regulation of serotonin transport in human K562 lymphocytes .
11306635	0	serotonin	14,23	corticotropin-releasing_factor	70,100	serotonin	corticotropin-releasing factor	MESH:D012701	1392	Chemical	Gene	Regulation|nmod|START_ENTITY release|nsubj|Regulation release|nmod|END_ENTITY	Regulation of serotonin release in the lateral septum and striatum by corticotropin-releasing_factor .
12172694	0	serotonin	58,67	corticotropin-releasing_factor	13,43	serotonin	corticotropin-releasing factor	MESH:D012701	81648(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Evidence for corticotropin-releasing_factor regulation of serotonin in the lateral septum during acute swim stress : adaptation produced by repeated swimming .
12566172	0	serotonin	10,19	corticotropin-releasing_factor	86,116	serotonin	corticotropin-releasing factor	MESH:D012701	81648(Tax:10116)	Chemical	Gene	depletion|compound|START_ENTITY Effect|nmod|depletion Effect|nmod|responses responses|nmod|END_ENTITY	Effect of serotonin depletion on the neuronal , endocrine and behavioural responses to corticotropin-releasing_factor in the rat .
15611993	0	serotonin	146,155	corticotropin-releasing_factor	91,121	serotonin	corticotropin-releasing factor	MESH:D012701	81648(Tax:10116)	Chemical	Gene	system|amod|START_ENTITY system|amod|gamma-aminobutyric_acid gamma-aminobutyric_acid|advcl|mediating mediating|dobj|effects effects|nmod|END_ENTITY	Ultrastructural evidence for a role of gamma-aminobutyric_acid in mediating the effects of corticotropin-releasing_factor on the rat dorsal raphe serotonin system .
18280562	0	serotonin	86,95	corticotropin-releasing_factor	14,44	serotonin	corticotropin-releasing factor	MESH:D012701	81648(Tax:10116)	Chemical	Gene	independent|nmod|START_ENTITY independent|nsubj|effect effect|nmod|END_ENTITY	The effect of corticotropin-releasing_factor on prepulse inhibition is independent of serotonin in Brown Norway and Wistar-Kyoto rats .
18534257	0	serotonin	27,36	corticotropin-releasing_factor	102,132	serotonin	corticotropin-releasing factor	MESH:D012701	81648(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY increases|dobj|release increases|nmod|nucleus nucleus|nmod|amygdala amygdala|nmod|activation activation|nmod|receptors receptors|amod|END_ENTITY	Restraint stress increases serotonin release in the central nucleus of the amygdala via activation of corticotropin-releasing_factor receptors .
24362954	0	serotonin	25,34	corticotropin-releasing_factor	69,99	serotonin	corticotropin-releasing factor	MESH:D012701	1392	Chemical	Gene	increases|nummod|START_ENTITY increases|nmod|expression expression|amod|END_ENTITY	Crowding stress inhibits serotonin 1A receptor-mediated increases in corticotropin-releasing_factor mRNA expression and adrenocorticotropin hormone secretion in the Gulf toadfish .
3022879	0	serotonin	11,20	corticotropin-releasing_factor	54,84	serotonin	corticotropin-releasing factor	MESH:D012701	81648(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|release release|amod|END_ENTITY	Effects of serotonin , cyproheptadine and reserpine on corticotropin-releasing_factor release from the rat hypothalamus in vitro .
6317143	0	serotonin	14,23	corticotropin-releasing_factor	57,87	serotonin	corticotropin-releasing factor	MESH:D012701	1392	Chemical	Gene	inhibitor|compound|START_ENTITY Effect|nmod|inhibitor fluoxetine|nsubj|Effect fluoxetine|nmod|secretion secretion|compound|END_ENTITY	Effect of the serotonin reuptake inhibitor fluoxetine on corticotropin-releasing_factor and vasopressin secretion into hypophysial portal blood .
9223539	0	serotonin	67,76	dopamine_D4_receptor	45,65	serotonin	dopamine D4 receptor	MESH:D012701	25432(Tax:10116)	Chemical	Gene	receptor|dep|START_ENTITY receptor|amod|END_ENTITY	In vitro and in vivo characterization of the dopamine_D4_receptor , serotonin 5-HT2A receptor and alpha-1 adrenoceptor antagonist -LRB- R -RRB- - -LRB- + -RRB- -2 - amino-4 - -LRB- 4-fluorophenyl -RRB- -5 - -LSB- 1 - -LSB- 4 - -LRB- 4-fluorophenyl -RRB- -4 - oxobutyl -RSB- _ pyrrolidin-3-yl -RSB- thiazole -LRB- NRA0045 -RRB- .
23585722	0	serotonin	11,20	erythropoietin	24,38	serotonin	erythropoietin	MESH:D012701	13856(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of serotonin on erythropoietin expression in mouse hippocampus .
26851523	0	serotonin	99,108	erythropoietin	67,81	serotonin	erythropoietin	MESH:D012701	2056	Chemical	Gene	using|dobj|START_ENTITY glycoforms|xcomp|using glycoforms|nsubj|chromatography chromatography|nmod|separation separation|nmod|END_ENTITY	Sialic acid-specific affinity chromatography for the separation of erythropoietin glycoforms using serotonin as a ligand .
7740505	0	serotonin	90,99	erythropoietin	131,145	serotonin	erythropoietin	MESH:D012701	2056	Chemical	Gene	START_ENTITY|nmod|therapy therapy|compound|END_ENTITY	A study of platelet functions , some hemostatic and fibrinolytic parameters in relation to serotonin in hemodialyzed patients under erythropoietin therapy .
9692616	0	serotonin	48,57	erythropoietin	21,35	serotonin	erythropoietin	MESH:D012701	2056	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|END_ENTITY	Long-term effects of erythropoietin on platelet serotonin storage and platelet_aggregation in hemodialysis patients with reference to ketanserin treatment .
44380	0	serotonin	20,29	gastrin	76,83	serotonin	gastrin	MESH:D012701	25320(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Effect of exogenous serotonin on intragastric pH and its influence on serum gastrin levels in rats .
6254118	0	serotonin	68,77	gastrin	37,44	serotonin	gastrin	MESH:D012701	25320(Tax:10116)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|mechanism mechanism|nmod|stimulation stimulation|nmod|END_ENTITY	Possible mechanism of stimulation of gastrin secretion by exogenous serotonin in rats .
21090245	0	serotonin	39,48	gp130	30,35	serotonin	gp130	MESH:D012701	16195(Tax:10090)	Chemical	Gene	system|compound|START_ENTITY END_ENTITY|nmod|system	-LSB- The role of the glycoprotein gp130 in serotonin mediator system in mouse brain -RSB- .
10686528	0	serotonin	23,32	growth_hormone	54,68	serotonin	growth hormone	MESH:D012701	403795(Tax:9615)	Chemical	Gene	receptor|compound|START_ENTITY Influence|nmod|receptor subtypes|nsubj|Influence subtypes|nmod|secretion secretion|amod|END_ENTITY	Influence of different serotonin receptor subtypes on growth_hormone secretion .
1261961	0	serotonin	34,43	growth_hormone	65,79	serotonin	growth hormone	MESH:D012701	2688	Chemical	Gene	antagonist|compound|START_ENTITY metergoline|appos|antagonist Effect|nmod|metergoline Effect|nmod|response response|compound|END_ENTITY	Effect of metergoline , a specific serotonin antagonist , on human growth_hormone response to arginine and L-dopa .
17217931	0	serotonin	24,33	growth_hormone	63,77	serotonin	growth hormone	MESH:D012701	2688	Chemical	Gene	promoter|amod|START_ENTITY Diplotypes|nmod|promoter predict|nsubj|Diplotypes predict|dobj|responses responses|amod|END_ENTITY	Diplotypes of the human serotonin 1B receptor promoter predict growth_hormone responses to sumatriptan in abstinent alcohol-dependent men .
6291713	0	serotonin	12,21	growth_hormone	50,64	serotonin	growth hormone	MESH:D012701	81668(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|nmod|END_ENTITY	Function of serotonin in physiologic secretion of growth_hormone and prolactin : action of 5,7-dihydroxytryptamine , fenfluramine and p-chlorophenylalanine .
7775648	0	serotonin	12,21	growth_hormone	70,84	serotonin	growth hormone	MESH:D012701	2688	Chemical	Gene	receptor|compound|START_ENTITY Role|nmod|receptor subtype|nsubj|Role subtype|nmod|secretion secretion|compound|END_ENTITY	Role of the serotonin receptor subtype 5-HT1D on basal and stimulated growth_hormone secretion .
8762730	0	serotonin	30,39	growth_hormone	103,117	serotonin	growth hormone	MESH:D012701	2688	Chemical	Gene	stimulation|nmod|START_ENTITY mediated|nsubj|stimulation mediated|ccomp|restore restore|dobj|responsiveness responsiveness|amod|END_ENTITY	Specific stimulation of brain serotonin mediated neurotransmission by dexfenfluramine does not restore growth_hormone responsiveness in obese women .
16251523	0	serotonin	58,67	htr1A	123,128	serotonin	htr1A	MESH:D012701	487230(Tax:9615)	Chemical	Gene	binding|compound|START_ENTITY involved|nmod|binding genes|acl|involved Structure|nmod|genes Structure|dep|gene gene|appos|END_ENTITY	Structure and variation of three canine genes involved in serotonin binding and transport : the serotonin_receptor_1A gene -LRB- htr1A -RRB- , serotonin_receptor_2A gene -LRB- htr2A -RRB- , and serotonin transporter gene -LRB- slc6A4 -RRB- .
1708470	0	serotonin	21,30	insulin	10,17	serotonin	insulin	MESH:D012701	396145(Tax:9031)	Chemical	Gene	contents|amod|START_ENTITY Effect|nmod|contents Effect|nmod|END_ENTITY	Effect of insulin on serotonin , 5-hydroxyindole-acetic_acid , norepinephrine , epinephrine and corticosterone contents in chick .
26206285	0	serotonin	8,17	insulin	83,90	serotonin	insulin	MESH:D012701	3630	Chemical	Gene	_|compound|START_ENTITY _|nsubj|_ _|ccomp|contribute contribute|nmod|END_ENTITY	Altered serotonin _ -LRB- 5-HT -RRB- _ 1D_and_2A_receptor expression may contribute to defective insulin and glucagon secretion in human type_2_diabetes .
5096997	0	serotonin	35,44	insulin	14,21	serotonin	insulin	MESH:D012701	3630	Chemical	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Inhibition of insulin secretion by serotonin and dopamine : species variation .
10869889	0	serotonin	11,20	interferon-gamma	84,100	serotonin	interferon-gamma	MESH:D012701	3458	Chemical	Gene	agonists|compound|START_ENTITY Effects|nmod|agonists Effects|nmod|production production|nmod|END_ENTITY	Effects of serotonin and serotonergic agonists and antagonists on the production of interferon-gamma and interleukin-10 .
3108386	0	serotonin	10,19	interferon-gamma	85,101	serotonin	interferon-gamma	MESH:D012701	15978(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|modulation modulation|nmod|phagocytosis phagocytosis|amod|END_ENTITY	Effect of serotonin -LRB- 5-HT -RRB- and other monoamines on murine macrophages : modulation of interferon-gamma induced phagocytosis .
8454908	0	serotonin	8,17	interferon-gamma	39,55	serotonin	interferon-gamma	MESH:D012701	3458	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|regulation regulation|nmod|production production|amod|END_ENTITY	Role of serotonin in the regulation of interferon-gamma production by human natural killer cells .
8958063	0	serotonin	78,87	interferon-gamma	136,152	serotonin	interferon-gamma	MESH:D012701	25712(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY mercuric_chloride|nmod|release effect|nmod|mercuric_chloride difference|nmod|effect mediated|nsubjpass|difference mediated|nmod|END_ENTITY	The strain difference in the effect of mercuric_chloride on antigen-triggered serotonin release from rat mast cells is not mediated via interferon-gamma .
9503251	0	serotonin	88,97	interferon-gamma	11,27	serotonin	interferon-gamma	MESH:D012701	25712(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	Effects of interferon-gamma , interleukin-1_beta , and tumor_necrosis_factor-alpha on the serotonin metabolism in the nucleus raphe dorsalis of the rat .
10210774	0	serotonin	70,79	interleukin-6	18,31	serotonin	interleukin-6	MESH:D012701	24498(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY Synergism|nmod|release Synergism|acl|END_ENTITY	Synergism between interleukin-6 and interleukin-1beta in hypothalamic serotonin release : a reverse in vivo microdialysis study in F344 rats .
11137624	0	serotonin	82,91	interleukin-6	11,24	serotonin	interleukin-6	MESH:D012701	24498(Tax:10116)	Chemical	Gene	concentrations|nmod|START_ENTITY increases|dobj|concentrations increases|nsubj|administration administration|amod|END_ENTITY	Peripheral interleukin-6 administration increases extracellular concentrations of serotonin and the evoked release of serotonin in the rat striatum .
12404674	0	serotonin	11,20	interleukin-6	52,65	serotonin	interleukin-6	MESH:D012701	3569	Chemical	Gene	depletion|compound|START_ENTITY Effects|nmod|depletion Effects|nmod|activation activation|amod|END_ENTITY	Effects of serotonin and catecholamine depletion on interleukin-6 activation and mood in human volunteers .
15302781	0	serotonin	19,28	interleukin-6	114,127	serotonin	interleukin-6	MESH:D012701	16193(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY Involvement|nmod|receptor Involvement|dep|control control|nmod|production production|amod|cytokine cytokine|dep|END_ENTITY	Involvement of the serotonin 5-HT2B receptor in cardiac_hypertrophy linked to sympathetic stimulation : control of interleukin-6 , interleukin-1beta , and tumor_necrosis_factor-alpha cytokine production by ventricular fibroblasts .
10437624	0	serotonin	86,95	leptin	17,23	serotonin	leptin	MESH:D012701	25608(Tax:10116)	Chemical	Gene	fluoxetine|amod|START_ENTITY treatment|nmod|fluoxetine plasma|nmod|treatment plasma|dobj|levels levels|compound|END_ENTITY	Decreased plasma leptin levels in lean and obese Zucker rats after treatment with the serotonin reuptake inhibitor fluoxetine .
10556680	0	serotonin	4,13	leptin	59,65	serotonin	leptin	MESH:D012701	16846(Tax:10090)	Chemical	Gene	5-hydroxytryptophan|compound|START_ENTITY elevates|nsubj|5-hydroxytryptophan elevates|dobj|levels levels|compound|END_ENTITY	The serotonin precursor 5-hydroxytryptophan elevates serum leptin levels in mice .
11011048	0	serotonin	62,71	leptin	6,12	serotonin	leptin	MESH:D012701	16846(Tax:10090)	Chemical	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	Serum leptin levels after central and systemic injection of a serotonin precursor , 5-hydroxytryptophan , in mice .
12021050	0	serotonin	75,84	leptin	118,124	serotonin	leptin	MESH:D012701	16846(Tax:10090)	Chemical	Gene	mediate|nsubj|START_ENTITY mediate|dobj|effects effects|nmod|END_ENTITY	Serotonergic activation rescues reproductive function in fasted mice : does serotonin mediate the metabolic effects of leptin on reproduction ?
12873793	2	serotonin	221,230	leptin	261,267	serotonin	leptin	MESH:D012701	25608(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY involved|nsubjpass|metabolism involved|nmod|actions actions|compound|END_ENTITY	There are evidence that increased serotonin metabolism may be involved in leptin actions .
16508167	0	serotonin	51,60	leptin	15,21	serotonin	leptin	MESH:D012701	16846(Tax:10090)	Chemical	Gene	5-hydroxytryptophan|amod|START_ENTITY induced|nmod|5-hydroxytryptophan induced|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of leptin in hypophagia induced by the serotonin precursor 5-hydroxytryptophan -LRB- 5-HTP -RRB- in mice .
23518461	0	serotonin	21,30	leptin	64,70	serotonin	leptin	MESH:D012701	25608(Tax:10116)	Chemical	Gene	stimulated|nsubjpass|START_ENTITY stimulated|nmod|hypophagia hypophagia|compound|END_ENTITY	Lateral hypothalamic serotonin is not stimulated during central leptin hypophagia .
26456504	0	serotonin	33,42	leptin	74,80	serotonin	leptin	MESH:D012701	25608(Tax:10116)	Chemical	Gene	effects|compound|START_ENTITY effects|nmod|END_ENTITY	Behavioral , hormonal and central serotonin modulating effects of injected leptin .
9593916	0	serotonin	48,57	monoamine_oxidase_A	27,46	serotonin	monoamine oxidase A	MESH:D012701	17161(Tax:10090)	Chemical	Gene	mRNA|dep|START_ENTITY mRNA|compound|END_ENTITY	Differential expression of monoamine_oxidase_A , serotonin transporter , tyrosine_hydroxylase and norepinephrine_transporter mRNA by anorexia mutation and food deprivation .
15039463	0	serotonin	98,107	myeloperoxidase	64,79	serotonin	myeloperoxidase	MESH:D012701	4353	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Oxygen radical-induced natural killer cell dysfunction : role of myeloperoxidase and regulation by serotonin .
11122373	0	serotonin	51,60	neurokinin-1	119,131	serotonin	neurokinin-1	MESH:D012701	6863	Chemical	Gene	evidence|nmod|START_ENTITY evidence|nmod|cells cells|acl:relcl|possess possess|dobj|receptor receptor|amod|END_ENTITY	Morphological evidence for selective modulation by serotonin of a subpopulation of dorsal horn cells which possess the neurokinin-1 receptor .
15030389	0	serotonin	113,122	neurokinin_1	25,37	serotonin	neurokinin 1	MESH:D012701	21333(Tax:10090)	Chemical	Gene	inhibitor|compound|START_ENTITY combined|nmod|inhibitor enhances|advcl|combined enhances|nsubj|Blockade Blockade|nmod|receptors receptors|appos|END_ENTITY	Blockade of substance_P -LRB- neurokinin_1 -RRB- receptors enhances extracellular serotonin when combined with a selective serotonin reuptake inhibitor : an in vivo microdialysis study in mice .
15030389	0	serotonin	72,81	neurokinin_1	25,37	serotonin	neurokinin 1	MESH:D012701	21333(Tax:10090)	Chemical	Gene	enhances|dobj|START_ENTITY enhances|nsubj|Blockade Blockade|nmod|receptors receptors|appos|END_ENTITY	Blockade of substance_P -LRB- neurokinin_1 -RRB- receptors enhances extracellular serotonin when combined with a selective serotonin reuptake inhibitor : an in vivo microdialysis study in mice .
16042979	0	serotonin	8,17	neuropeptide_Y	66,80	serotonin	neuropeptide Y	MESH:D012701	109648(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|properties properties|nmod|END_ENTITY	Role of serotonin -LRB- 5-HT -RRB- in the antidepressant-like properties of neuropeptide_Y -LRB- NPY -RRB- in the mouse forced swim test .
8616599	0	serotonin	4,13	neuropeptide_Y	55,69	serotonin	neuropeptide Y	MESH:D012701	24604(Tax:10116)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|synthesis synthesis|amod|END_ENTITY	The serotonin -LRB- 5-HT -RRB- antagonist methysergide increases neuropeptide_Y -LRB- NPY -RRB- synthesis and secretion in the hypothalamus of the rat .
23407616	0	serotonin	89,98	organic_cation_transporter-3	15,43	serotonin	organic cation transporter-3	MESH:D012701	100049579	Chemical	Gene	uptake|compound|START_ENTITY END_ENTITY|nmod|uptake	Involvement of organic_cation_transporter-3 and plasma_membrane_monoamine_transporter in serotonin uptake in human brain vascular smooth muscle cells .
2315313	0	serotonin	109,118	phospholipase_A2	21,37	serotonin	phospholipase A2	MESH:D012701	151056	Chemical	Gene	receptor|compound|START_ENTITY stimulates|nmod|receptor stimulates|dobj|END_ENTITY	Serotonin stimulates phospholipase_A2 and the release of arachidonic_acid in hippocampal neurons by a type 2 serotonin receptor that is independent of inositolphospholipid hydrolysis .
10860641	0	serotonin	23,32	prolactin	208,217	serotonin	prolactin	MESH:D012701	24683(Tax:10116)	Chemical	Gene	antagonist|compound|START_ENTITY Isoteoline|appos|antagonist inhibits|nsubj|Isoteoline inhibits|dobj|_ _|dep|increase increase|nmod|levels levels|compound|END_ENTITY	Isoteoline , a putative serotonin antagonist , inhibits meta _ - chlorophenylpiperazine , but not 1 - -LRB- 2 , _ - dimethoxy-4-iodphenyl -RRB- -2 - aminopropane and 8-hydroxy-2 - -LRB- di-n-propylamino -RRB- - tetraline-induced increase of serum prolactin levels .
11456281	0	serotonin	10,19	prolactin	64,73	serotonin	prolactin	MESH:D012701	24683(Tax:10116)	Chemical	Gene	depletion|compound|START_ENTITY depletion|nmod|p-chlorophenylalanine p-chlorophenylalanine|nmod|levels levels|compound|END_ENTITY	Effect of serotonin depletion by p-chlorophenylalanine on serum prolactin levels in estrogen-treated ovariectomized rats : insights concerning the serotoninergic , dopaminergic and opioid systems .
126860	0	serotonin	37,46	prolactin	68,77	serotonin	prolactin	MESH:D012701	24683(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY blocker|nmod|receptors Effect|appos|blocker Effect|nmod|levels levels|compound|END_ENTITY	Effect of methysergide , a blocker of serotonin receptors , on plasma prolactin levels in lactating and ovariectomized rats .
1332851	0	serotonin	100,109	prolactin	41,50	serotonin	prolactin	MESH:D012701	24683(Tax:10116)	Chemical	Gene	ontogeny|nmod|START_ENTITY control|dep|ontogeny control|nmod|secretion secretion|compound|END_ENTITY	Mu - and kappa-opiate receptor control of prolactin secretion in rats : ontogeny and interaction with serotonin .
1352053	0	serotonin	87,96	prolactin	171,180	serotonin	prolactin	MESH:D012701	24683(Tax:10116)	Chemical	Gene	binding|amod|START_ENTITY changes|nmod|binding induces|dobj|changes induces|advcl|altering altering|dobj|secretion secretion|compound|END_ENTITY	Long-term administration of m-chlorophenylpiperazine -LRB- mCPP -RRB- to rats induces changes in serotonin receptor binding , dopamine levels and locomotor activity without altering prolactin and corticosterone secretion .
14724063	0	serotonin	153,162	prolactin	11,20	serotonin	prolactin	MESH:D012701	24683(Tax:10116)	Chemical	Gene	dopamine|appos|START_ENTITY Changes|nmod|dopamine Changes|nmod|mechanisms mechanisms|amod|END_ENTITY	Changes of prolactin regulatory mechanisms in aging : 24-h rhythms of serum prolactin and median eminence and adenohypophysial concentration of dopamine , serotonin , -LRB- gamma-aminobutyric_acid , taurine and somatostatin in young and aged rats .
1986602	0	serotonin	12,21	prolactin	103,112	serotonin	prolactin	MESH:D012701	5617	Chemical	Gene	inhibitor|compound|START_ENTITY modulates|nsubj|inhibitor modulates|dobj|release release|nmod|END_ENTITY	A selective serotonin reuptake inhibitor , fluoxetine_hydrochloride , modulates the pulsatile release of prolactin in postmenopausal women .
21404115	0	serotonin	53,62	prolactin	27,36	serotonin	prolactin	MESH:D012701	5617	Chemical	Gene	turnover|compound|START_ENTITY marker|nmod|turnover END_ENTITY|nmod|marker	Clomipramine-induced serum prolactin as a marker for serotonin and dopamine turnover : results of an open label study .
2479530	0	serotonin	8,17	prolactin	53,62	serotonin	prolactin	MESH:D012701	24683(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY surges|nsubj|Role surges|nmod|END_ENTITY	Role of serotonin in nocturnal and diurnal surges of prolactin in the pregnant rat .
2524399	0	serotonin	36,45	prolactin	83,92	serotonin	prolactin	MESH:D012701	24683(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY characterization|nmod|receptors involved|nsubj|characterization involved|nmod|control control|nmod|secretion secretion|compound|END_ENTITY	Pharmacological characterization of serotonin receptors involved in the control of prolactin secretion .
3106183	0	serotonin	26,35	prolactin	49,58	serotonin	prolactin	MESH:D012701	5617	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Possible direct effect of serotonin on pituitary prolactin secretion : in vivo and in vitro studies .
3107298	0	serotonin	10,19	prolactin	56,65	serotonin	prolactin	MESH:D012701	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	Effect of serotonin on basal and TRH-induced release of prolactin from rat pituitary glands in vitro .
311282	0	serotonin	60,69	prolactin	19,28	serotonin	prolactin	MESH:D012701	24683(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY levels|nmod|inhibition levels|compound|END_ENTITY	Elevation of serum prolactin levels after the inhibition of serotonin uptake .
313251	0	serotonin	10,19	prolactin	23,32	serotonin	prolactin	MESH:D012701	5617	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of serotonin on prolactin - and MSH-secreting cells in the eel .
3197951	0	serotonin	15,24	prolactin	28,37	serotonin	prolactin	MESH:D012701	100303694(Tax:9103)	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	Involvement of serotonin in prolactin release induced by electrical stimulation of the hypothalamus of the turkey -LRB- Meleagris_gallopavo -RRB- .
3362407	0	serotonin	38,47	prolactin	13,22	serotonin	prolactin	MESH:D012701	443317(Tax:9940)	Chemical	Gene	response|nmod|START_ENTITY END_ENTITY|nmod|response	Secretion of prolactin in response to serotonin requires an intact hypothalamo-pituitary axis in the ewe .
3441315	0	serotonin	38,47	prolactin	13,22	serotonin	prolactin	MESH:D012701	443317(Tax:9940)	Chemical	Gene	response|nmod|START_ENTITY END_ENTITY|nmod|response	Secretion of prolactin in response to serotonin requires an intact hypothalamo-pituitary axis in the ewe .
3841211	0	serotonin	84,93	prolactin	53,62	serotonin	prolactin	MESH:D012701	24683(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Involvement Involvement|nmod|histidine_isoleucine histidine_isoleucine|nmod|secretion secretion|compound|END_ENTITY	Involvement of peptide histidine_isoleucine -LRB- PHI -RRB- in prolactin secretion induced by serotonin in rats .
3872804	0	serotonin	101,110	prolactin	70,79	serotonin	prolactin	MESH:D012701	24683(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Inhibition Inhibition|nmod|antiserum antiserum|nmod|secretion secretion|compound|END_ENTITY	Inhibition by antiserum to vasoactive_intestinal_polypeptide -LRB- VIP -RRB- of prolactin secretion induced by serotonin in the rat .
401022	0	serotonin	22,31	prolactin	81,90	serotonin	prolactin	MESH:D012701	24683(Tax:10116)	Chemical	Gene	evidence|dep|START_ENTITY neurotransmitter|nsubj|evidence neurotransmitter|acl|involved involved|nmod|control control|nmod|secretion secretion|compound|END_ENTITY	Further evidence that serotonin is a neurotransmitter involved in the control of prolactin secretion .
510375	0	serotonin	123,132	prolactin	100,109	serotonin	prolactin	MESH:D012701	24683(Tax:10116)	Chemical	Gene	agonists|compound|START_ENTITY potentiates|nmod|agonists potentiates|dobj|stimulation stimulation|nmod|secretion secretion|compound|END_ENTITY	Repeated administration of 5-methoxy-N , N-dimethyltryptamine to male rats potentiates stimulation of prolactin secretion by serotonin agonists .
6133307	0	serotonin	10,19	prolactin	106,115	serotonin	prolactin	MESH:D012701	5617	Chemical	Gene	receptor|compound|START_ENTITY receptor|acl|blocking blocking|nmod|level level|compound|END_ENTITY	Dopamine , serotonin and alpha-adrenergic receptor blocking activities in serum and their relationships to prolactin level in schizophrenic patients receiving long-term chlorpromazine treatment .
6227192	0	serotonin	13,22	prolactin	34,43	serotonin	prolactin	MESH:D012701	396453(Tax:9031)	Chemical	Gene	effects|compound|START_ENTITY Mechanism|nmod|effects Mechanism|nmod|secretion secretion|compound|END_ENTITY	Mechanism of serotonin effects on prolactin and growth_hormone secretion in domestic fowl .
662080	0	serotonin	25,34	prolactin	102,111	serotonin	prolactin	MESH:D012701	5617	Chemical	Gene	antagonists|compound|START_ENTITY suppression|nmod|antagonists suppression|dep|evidence evidence|nmod|control control|nmod|secretion secretion|compound|END_ENTITY	Prolactin suppression by serotonin antagonists in man : further evidence for serotoninergic control of prolactin secretion .
6709640	0	serotonin	102,111	prolactin	71,80	serotonin	prolactin	MESH:D012701	24683(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Involvement Involvement|nmod|vasoactive_intestinal_polypeptide vasoactive_intestinal_polypeptide|nmod|secretion secretion|compound|END_ENTITY	Involvement of hypothalamic vasoactive_intestinal_polypeptide -LRB- VIP -RRB- in prolactin secretion induced by serotonin in rats .
692379	0	serotonin	35,44	prolactin	14,23	serotonin	prolactin	MESH:D012701	5617	Chemical	Gene	antagonists|compound|START_ENTITY release|nmod|antagonists release|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of prolactin release by serotonin antagonists in hyperprolactinemic subjects .
7405671	0	serotonin	10,19	prolactin	23,32	serotonin	prolactin	MESH:D012701	5617	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of serotonin on prolactin secretion in vitro .
7437907	0	serotonin	40,49	prolactin	65,74	serotonin	prolactin	MESH:D012701	5617	Chemical	Gene	antagonists|compound|START_ENTITY Characterization|nmod|antagonists Characterization|nmod|profiles profiles|compound|END_ENTITY	Characterization of ergot and non-ergot serotonin antagonists by prolactin and growth_hormone profiles during wakefulness and sleep .
8082037	0	serotonin	8,17	prolactin	39,48	serotonin	prolactin	MESH:D012701	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|regulation regulation|nmod|expression expression|compound|END_ENTITY	Role of serotonin in the regulation of prolactin gene expression in the male rat as evaluated by in situ hybridization .
8321411	0	serotonin	20,29	prolactin	51,60	serotonin	prolactin	MESH:D012701	24683(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY Effect|nmod|receptor agonists|nsubj|Effect agonists|nmod|secretion secretion|compound|END_ENTITY	Effect of selective serotonin receptor agonists on prolactin secretion in male rats .
8954759	0	serotonin	36,45	prolactin	57,66	serotonin	prolactin	MESH:D012701	100303694(Tax:9103)	Chemical	Gene	ability|nmod|START_ENTITY mediates|dobj|ability mediates|xcomp|release release|dobj|END_ENTITY	Photoperiod mediates the ability of serotonin to release prolactin in the turkey .
9822800	0	serotonin	17,26	prolactin	30,39	serotonin	prolactin	MESH:D012701	5617	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	Direct action of serotonin on prolactin , growth_hormone , corticotropin and luteinizing hormone release in cocultures of anterior and posterior pituitary lobes : autocrine and/or paracrine action of vasoactive intestinal peptide .
991435	0	serotonin	14,23	prolactin	39,48	serotonin	prolactin	MESH:D012701	5617	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|nmod|END_ENTITY	Effect of two serotonin antagonists on prolactin and thyrotrophin secretion in man .
19740092	4	serotonin	738,747	rats	770,774	serotonin	SERT	MESH:D012701	25553(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY levels|nmod|END_ENTITY	In rats , SERT genotype is known to affect brain serotonin levels , with SERT -LRB- - / - -RRB- rats having lower intracellular basal serotonin levels than wild-type rats in several brain areas .
7019933	0	serotonin	11,20	renin	57,62	serotonin	renin	MESH:D012701	24715(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|compound|END_ENTITY	Effects of serotonin and L-5-hydroxytryptophan on plasma renin activity in rats .
18314975	0	serotonin	11,20	serotonin_transporter	34,55	serotonin	serotonin transporter	MESH:D012701	6532	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of serotonin to the human serotonin_transporter .
18712364	0	serotonin	83,92	serotonin_transporter	103,124	serotonin	serotonin transporter	MESH:D012701	15567(Tax:10090)	Chemical	Gene	levels|compound|START_ENTITY levels|nmod|END_ENTITY	Neurochemical , behavioral , and physiological effects of pharmacologically enhanced serotonin levels in serotonin_transporter -LRB- SERT -RRB- - deficient mice .
18983505	0	serotonin	24,33	serotonin_transporter	109,130	serotonin	serotonin transporter	MESH:D012701	6532	Chemical	Gene	paroxetine|amod|START_ENTITY Effect|nmod|paroxetine modified|nsubjpass|Effect modified|nmod|polymorphism polymorphism|compound|END_ENTITY	Effect of the selective serotonin reuptake inhibitor paroxetine on platelet function is modified by a SLC6A4 serotonin_transporter polymorphism .
16251523	0	serotonin	171,180	slc6A4	199,205	serotonin	slc6A4	MESH:D012701	491184(Tax:9615)	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Structure and variation of three canine genes involved in serotonin binding and transport : the serotonin_receptor_1A gene -LRB- htr1A -RRB- , serotonin_receptor_2A gene -LRB- htr2A -RRB- , and serotonin transporter gene -LRB- slc6A4 -RRB- .
6477519	0	serotonin	45,54	thrombin	16,24	serotonin	thrombin	MESH:D012701	2147	Chemical	Gene	secretion|nmod|START_ENTITY END_ENTITY|nmod|secretion	Potentiation by thrombin of the secretion of serotonin from permeabilized platelets equilibrated with Ca2 + buffers .
1291403	0	serotonin	10,19	thyrotropin-releasing_hormone	42,71	serotonin	thyrotropin-releasing hormone	MESH:D012701	25569(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|concentrations concentrations|amod|END_ENTITY	Effect of serotonin on the immunoreactive thyrotropin-releasing_hormone concentrations of the rat stomach .
2986203	0	serotonin	103,112	thyrotropin-releasing_hormone	17,46	serotonin	thyrotropin-releasing hormone	MESH:D012701	25569(Tax:10116)	Chemical	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|receptors receptors|amod|END_ENTITY	Up-regulation of thyrotropin-releasing_hormone -LRB- TRH -RRB- receptors in rat spinal cord after codepletion of serotonin and TRH .
3147290	0	serotonin	17,26	thyrotropin-releasing_hormone	75,104	serotonin	thyrotropin-releasing hormone	MESH:D012701	7200	Chemical	Gene	START_ENTITY|dep|enhancement enhancement|nmod|effects effects|nmod|END_ENTITY	Dorsal medullary serotonin and gastric motility : enhancement of effects by thyrotropin-releasing_hormone .
8738109	0	serotonin	11,20	thyrotropin-releasing_hormone	39,68	serotonin	thyrotropin-releasing hormone	MESH:D012701	25569(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|release release|nmod|END_ENTITY	Effects of serotonin on the release of thyrotropin-releasing_hormone from the rat retina in vitro .
18557609	0	serotonin	25,34	tryptophan_hydroxylase	51,73	serotonin	tryptophan hydroxylase	MESH:D012701	21990(Tax:10090)	Chemical	Gene	levels|compound|START_ENTITY levels|nmod|END_ENTITY	Modulation of peripheral serotonin levels by novel tryptophan_hydroxylase inhibitors for the potential treatment of functional gastrointestinal_disorders .
3390820	0	serotonin	18,27	tumor_necrosis_factor-alpha	74,101	serotonin	tumor necrosis factor-alpha	MESH:D012701	7124	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Important role of serotonin in the antitumor effects of recombinant human tumor_necrosis_factor-alpha in mice .
15892984	0	serotonin	11,20	tumor_necrosis_factor_alpha	84,111	serotonin	tumor necrosis factor alpha	MESH:D012701	7124	Chemical	Gene	agonists|compound|START_ENTITY Effects|nmod|agonists Effects|nmod|production production|nmod|END_ENTITY	Effects of serotonin and serotonergic agonists and antagonists on the production of tumor_necrosis_factor_alpha and interleukin-6 .
1685852	0	serotonin	11,20	tyrosine_hydroxylase	24,44	serotonin	tyrosine hydroxylase	MESH:D012701	7054	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|protein protein|compound|END_ENTITY	Effects of serotonin on tyrosine_hydroxylase and tau protein in a human neuroblastoma cell line .
21554649	0	serotonin	26,35	tyrosine_hydroxylase	46,66	serotonin	tyrosine hydroxylase	MESH:D012701	25085(Tax:10116)	Chemical	Gene	administration|nmod|START_ENTITY decreases|nsubj|administration decreases|dobj|activity activity|amod|END_ENTITY	Central administration of serotonin decreases tyrosine_hydroxylase catalytic activity and messenger ribonucleic Acid signal levels in the hypothalamus of female rats .
2886550	0	serotonin	47,56	tyrosine_hydroxylase	14,34	serotonin	tyrosine hydroxylase	MESH:D012701	25085(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Inhibition of tyrosine_hydroxylase activity by serotonin in explants of newborn rat locus ceruleus .
6123957	0	serotonin	31,40	tyrosine_hydroxylase	80,100	serotonin	tyrosine hydroxylase	MESH:D012701	25085(Tax:10116)	Chemical	Gene	c-AMP|dep|START_ENTITY Alterations|nmod|c-AMP Alterations|nmod|END_ENTITY	Alterations in norepinephrine , serotonin , c-AMP , and transsynaptic induction of tyrosine_hydroxylase after spinal cord transection in the rat .
12058528	0	serotonin	11,20	vasoactive_intestinal_polypeptide	61,94	serotonin	vasoactive intestinal polypeptide	MESH:D012701	117064(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|differentiation differentiation|nmod|neurons neurons|acl|producing producing|dobj|END_ENTITY	-LSB- Effect of serotonin on differentiation of neurons producing vasoactive_intestinal_polypeptide in the rat suprachiasmatic_nucleus -RSB- .
14552543	0	serotonin	15,24	vasoactive_intestinal_polypeptide	69,102	serotonin	vasoactive intestinal polypeptide	MESH:D012701	117064(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nsubj|effects	The effects of serotonin on the differentiation of neurons producing vasoactive_intestinal_polypeptide in the suprachiasmatic nucleus of the rat .
3872804	0	serotonin	101,110	vasoactive_intestinal_polypeptide	27,60	serotonin	vasoactive intestinal polypeptide	MESH:D012701	117064(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Inhibition Inhibition|nmod|antiserum antiserum|acl|END_ENTITY	Inhibition by antiserum to vasoactive_intestinal_polypeptide -LRB- VIP -RRB- of prolactin secretion induced by serotonin in the rat .
6709640	0	serotonin	102,111	vasoactive_intestinal_polypeptide	28,61	serotonin	vasoactive intestinal polypeptide	MESH:D012701	117064(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of hypothalamic vasoactive_intestinal_polypeptide -LRB- VIP -RRB- in prolactin secretion induced by serotonin in rats .
7084118	0	serotonin	15,24	vasoactive_intestinal_polypeptide	28,61	serotonin	vasoactive intestinal polypeptide	MESH:D012701	117064(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|release release|amod|END_ENTITY	Stimulation by serotonin of vasoactive_intestinal_polypeptide release into rat hypophysial portal blood .
21814181	0	serotonin	103,112	vesicular_monoamine_transporter_2	61,94	serotonin	vesicular monoamine transporter 2	MESH:D012701	214084(Tax:10090)	Chemical	Gene	neurons|compound|START_ENTITY gene|nmod|neurons gene|amod|END_ENTITY	Severe serotonin depletion after conditional deletion of the vesicular_monoamine_transporter_2 gene in serotonin neurons : neural and behavioral consequences .
8842634	0	serotonin1B	15,26	5HT1B	28,33	serotonin1B	5HT1B	null	25075(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Alterations in serotonin1B -LRB- 5HT1B -RRB- receptor subtypes in the brain of ethanol-treated rats .
20128812	0	serotonin_5-HT	124,138	SERT	152,156	serotonin 5-HT	SERT	null	15567(Tax:10090)	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Functional interactions between 5-HT2A and presynaptic 5-HT1A_receptor-based responses in mice genetically_deficient in the serotonin_5-HT transporter -LRB- SERT -RRB- .
10915803	0	serpentine	52,62	follitropin_receptor	77,97	serpentine	follitropin receptor	CHEBI:46670	2492	Chemical	Gene	region|amod|START_ENTITY region|nmod|END_ENTITY	Multiple distant amino_acid residues present in the serpentine region of the follitropin_receptor modulate the rate of agonist-induced internalization .
18822694	0	sertraline	62,72	5-HTTLPR	0,8	sertraline	5-HTTLPR	MESH:D020280	6532	Chemical	Gene	polymorphism|nmod|START_ENTITY polymorphism|nummod|END_ENTITY	5-HTTLPR polymorphism of serotonin_transporter and effects of sertraline in terminally ill cancer patients : report of eleven cases .
18710373	0	sertraline	19,29	Akt	44,47	sertraline	Akt	MESH:D020280	207	Chemical	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	The antidepressant sertraline downregulates Akt and has activity against melanoma cells .
10196464	0	sertraline	80,90	CCK	14,17	sertraline	CCK	MESH:D020280	25298(Tax:10116)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of CCK mRNA expression in the rat brain by stress and treatment with sertraline , a selective serotonin re-uptake inhibitor .
10510155	0	sertraline	82,92	CYP2C19	40,47	sertraline	CYP2C19	MESH:D020280	1557	Chemical	Gene	N-demethylation|nmod|START_ENTITY polymorphic|nmod|N-demethylation polymorphic|dep|END_ENTITY	Evidence for involvement of polymorphic CYP2C19 and 2C9 in the N-demethylation of sertraline in human liver microsomes .
11452243	0	sertraline	20,30	CYP2C19	70,77	sertraline	CYP2C19	MESH:D020280	1557	Chemical	Gene	Pharmacokinetics|nmod|START_ENTITY Pharmacokinetics|nmod|END_ENTITY	Pharmacokinetics of sertraline in relation to genetic polymorphism of CYP2C19 .
18677622	0	sertraline	24,34	CYP2C19	77,84	sertraline	CYP2C19	MESH:D020280	1557	Chemical	Gene	START_ENTITY|nmod|relation relation|nmod|END_ENTITY	Serum concentrations of sertraline and N-desmethyl_sertraline in relation to CYP2C19 genotype in psychiatric patients .
23583289	0	sertraline	35,45	galanin	13,20	sertraline	galanin	MESH:D020280	14419(Tax:10090)	Chemical	Gene	treatment|compound|START_ENTITY END_ENTITY|nmod|treatment	Induction of galanin after chronic sertraline treatment in mouse ventral dentate gyrus .
23468867	0	sertraline	11,21	p-glycoprotein	40,54	sertraline	p-glycoprotein	MESH:D020280	67078(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of sertraline and fluoxetine on p-glycoprotein at barrier sites : in vivo and in vitro approaches .
20851877	0	sesamin	14,21	cytochrome_P450	25,40	sesamin	cytochrome P450	MESH:C054125	4051	Chemical	Gene	Metabolism|nmod|START_ENTITY Metabolism|nmod|END_ENTITY	Metabolism of sesamin by cytochrome_P450 in human liver microsomes .
21622626	0	sesamin	25,32	cytochrome_P450	36,51	sesamin	cytochrome P450	MESH:C054125	4051	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|nmod|END_ENTITY	Sequential metabolism of sesamin by cytochrome_P450 and UDP-glucuronosyltransferase in human liver .
23624775	0	sesamol	79,86	NGF	15,18	sesamol	NGF	MESH:C025583	310738(Tax:10116)	Chemical	Gene	Implication|nmod|START_ENTITY Implication|nmod|END_ENTITY	Implication of NGF and endocannabinoid signaling in the mechanism of action of sesamol : a multi-target natural compound with therapeutic potential .
21144881	0	sesamol	15,22	tyrosinase	55,65	sesamol	tyrosinase	MESH:C025583	22173(Tax:10090)	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of sesamol -LRB- 3,4-methylenedioxyphenol -RRB- with tyrosinase and its effect on melanin synthesis .
16297850	0	sesquiterpene	112,125	At4g13280	141,150	sesquiterpene	At4g13280	CHEBI:35189	826958(Tax:3702)	Chemical	Gene	synthase|compound|START_ENTITY synthase|dep|END_ENTITY	Microarray expression profiling and functional characterization of AtTPS genes : duplicated Arabidopsis_thaliana sesquiterpene synthase genes At4g13280 and At4g13300 encode root-specific and wound-inducible -LRB- Z -RRB- - gamma-bisabolene_synthases .
16464597	0	sesquiterpene	4,17	brain-derived_neurotrophic_factor	71,104	sesquiterpene	brain-derived neurotrophic factor	CHEBI:35189	24225(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	New sesquiterpene from Vietnamese agarwood and its induction effect on brain-derived_neurotrophic_factor mRNA expression in vitro .
11374954	0	sesquiterpene	4,17	phospholipase_A2	111,127	sesquiterpene	phospholipase A2	CHEBI:35189	151056	Chemical	Gene	START_ENTITY|nmod|profile profile|nmod|END_ENTITY	New sesquiterpene derivatives from the sponge Dysidea species with a selective inhibitor profile against human phospholipase_A2 and other leukocyte functions .
22784363	0	sesquiterpene_lactone	28,49	p65	6,9	sesquiterpene lactone	p65	CHEBI:37667	5970	Chemical	Gene	repression|nmod|START_ENTITY repression|amod|END_ENTITY	NF-kB p65 repression by the sesquiterpene_lactone , Helenalin , contributes to the induction of autophagy cell death .
16354403	0	sesquiterpene_lactone_ergolide	23,53	NF-kappaB	80,89	sesquiterpene lactone ergolide	NF-kappaB	null	4790	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Apoptotic potential of sesquiterpene_lactone_ergolide through the inhibition of NF-kappaB signaling pathway .
12732368	0	sesquiterpene_lactones	10,32	CD69	76,80	sesquiterpene lactones	CD69	CHEBI:37667	969	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effect of sesquiterpene_lactones on the expression of the activation marker CD69 and of IL-2 in T-lymphocytes in whole blood .
11551526	0	sesquiterpene_lactones	102,124	NF-kappaB	171,180	sesquiterpene lactones	NF-kappaB	CHEBI:37667	18033(Tax:10090)	Chemical	Gene	production|nmod|START_ENTITY Inhibition|nmod|production correlates|nsubj|Inhibition correlates|nmod|activation activation|nmod|END_ENTITY	Inhibition of inflammatory cytokine production and lymphocyte proliferation by structurally different sesquiterpene_lactones correlates with their effect on activation of NF-kappaB .
15537359	0	sesquiterpene_lactones	48,70	NF-kappaB	113,122	sesquiterpene lactones	NF-kappaB	CHEBI:37667	4790	Chemical	Gene	relationship|nmod|START_ENTITY END_ENTITY|nsubj|relationship	Quantitative structure-activity relationship of sesquiterpene_lactones as inhibitors of the transcription factor NF-kappaB .
16570920	0	sesquiterpene_lactones	62,84	NF-kappaB	38,47	sesquiterpene lactones	NF-kappaB	CHEBI:37667	4790	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Development of a structural model for NF-kappaB inhibition of sesquiterpene_lactones using self-organizing neural networks .
17479992	0	sesquiterpenoid_alcohol_longifolol	80,114	UDP-glucuronosyltransferase_2B7	31,62	sesquiterpenoid alcohol longifolol	UDP-glucuronosyltransferase 2B7	null	7364	Chemical	Gene	derived|nmod|START_ENTITY derived|nsubj|inhibitors inhibitors|nmod|END_ENTITY	Potent inhibitors of the human UDP-glucuronosyltransferase_2B7 derived from the sesquiterpenoid_alcohol_longifolol .
16665452	0	sesquiterpenoid_phytoalexin	84,111	3-hydroxy-3-methylglutaryl_coenzyme_a_reductase	15,62	sesquiterpenoid phytoalexin	3-hydroxy-3-methylglutaryl coenzyme a reductase	null	102577467	Chemical	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Involvement of 3-hydroxy-3-methylglutaryl_coenzyme_a_reductase in the regulation of sesquiterpenoid_phytoalexin synthesis in potato .
24214422	0	setipiprant	30,41	CRTH2	60,65	setipiprant	CRTH2	null	11251	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Disposition and metabolism of setipiprant , a selective oral CRTH2 antagonist , in humans .
16272625	0	sevelamer_hydrochloride	34,57	PTH	87,90	sevelamer hydrochloride	PTH	MESH:C405346	5741	Chemical	Gene	Treatment|dep|START_ENTITY based|nsubj|Treatment based|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Treatment with phosphate binder -LRB- sevelamer_hydrochloride , calcium_carbonate -RRB- based on PTH -RSB- .
17443033	0	sevelamer_hydrochloride	10,33	PTH	111,114	sevelamer hydrochloride	PTH	MESH:C405346	5741	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|compound|END_ENTITY	Effect of sevelamer_hydrochloride on markers of bone turnover in Japanese dialysis patients with low biointact PTH levels .
16155662	0	sevoflurane	11,22	CA1	41,44	sevoflurane	CA1	MESH:C009250	310218(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of sevoflurane and desflurane in CA1 after incomplete cerebral_ischemia in rats .
18241841	0	sevoflurane	38,49	CA1	135,138	sevoflurane	CA1	MESH:C009250	12346(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY hippocampal|nsubj|effects hippocampal|dobj|area area|compound|END_ENTITY	Facilitatory effects of subanesthetic sevoflurane on excitatory synaptic transmission and synaptic plasticity in the mouse hippocampal CA1 area .
18292682	0	sevoflurane	27,38	CA1	82,85	sevoflurane	CA1	MESH:C009250	310218(Tax:10116)	Chemical	Gene	concentrations|nmod|START_ENTITY inhibit|nsubj|concentrations inhibit|dobj|plasticity plasticity|nmod|neurons neurons|compound|END_ENTITY	Amnestic concentrations of sevoflurane inhibit synaptic plasticity of hippocampal CA1 neurons through gamma-aminobutyric_acid-mediated mechanisms .
24518287	0	sevoflurane	18,29	CA1	79,82	sevoflurane	CA1	MESH:C009250	310218(Tax:10116)	Chemical	Gene	exposure|nmod|START_ENTITY inhibits|nsubj|exposure inhibits|nmod|neurons neurons|compound|END_ENTITY	Early exposure to sevoflurane inhibits Ca -LRB- 2 + -RRB- channels activity in hippocampal CA1 pyramidal neurons of developing rats .
8922750	0	sevoflurane	16,27	CA1	107,110	sevoflurane	CA1	MESH:C009250	310218(Tax:10116)	Chemical	Gene	Potentiation|nmod|START_ENTITY dissociated|nsubj|Potentiation dissociated|dobj|neurones neurones|nummod|END_ENTITY	Potentiation by sevoflurane of the gamma-aminobutyric_acid-induced chloride current in acutely dissociated CA1 pyramidal neurones from rat hippocampus .
9249125	0	sevoflurane	15,26	CA1	51,54	sevoflurane	CA1	MESH:C009250	310218(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|spikes spikes|nmod|gyrus gyrus|compound|END_ENTITY	The effects of sevoflurane on population spikes in CA1 and dentate gyrus of the rat hippocampus in vitro .
17567648	0	sevoflurane	11,22	CFTR	115,119	sevoflurane	CFTR	MESH:C009250	12638(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|dep|END_ENTITY	Effects of sevoflurane on the cAMP-induced short-circuit current in mouse tracheal epithelium and recombinant Cl - -LRB- CFTR -RRB- and K + -LRB- KCNQ1 -RRB- channels .
3142969	0	sevoflurane	10,21	P50	25,28	sevoflurane	P50	MESH:C009250	4790	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of sevoflurane on P50 and on measurement of oxygen tension .
26696094	0	sevoflurane	20,31	Per2	43,47	sevoflurane	Per2	MESH:C009250	63840(Tax:10116)	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|expression expression|amod|END_ENTITY	Characterization of sevoflurane effects on Per2 expression using ex vivo bioluminescence imaging of the suprachiasmatic nucleus in transgenic rats .
26856295	0	sevoflurane	11,22	S100b	39,44	sevoflurane	S100b	MESH:C009250	6285	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of sevoflurane and propofol on S100b and neuron-specific_enolase protein levels during cardiopulmonary bypass .
12790209	0	sevoflurane	10,21	TNF-alpha	50,59	sevoflurane	TNF-alpha	MESH:C009250	7124	Chemical	Gene	START_ENTITY|nmod|secretion secretion|nmod|END_ENTITY	Effect of sevoflurane on the ex vivo secretion of TNF-alpha during and after coronary artery bypass surgery .
8721129	0	sevoflurane	11,22	TNF-alpha	37,46	sevoflurane	TNF-alpha	MESH:C009250	7124	Chemical	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	-LSB- Effect of sevoflurane on release of TNF-alpha and IL-1_beta from human monocytes -RSB- .
9621453	0	shikimic_acid	19,32	PEP	66,69	shikimic acid	PEP	MESH:D012765	5047	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	The interaction of shikimic_acid and protein phosphorylation with PEP carboxylase from the C4 dicot Amaranthus viridis .
25471124	0	shikonin	10,18	SIRT1	65,70	shikonin	SIRT1	MESH:C016101	23411	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|role role|nmod|END_ENTITY	Effect of shikonin on multidrug resistance in HepG2 : The role of SIRT1 .
16857719	0	short-chain_fatty_acids	59,82	Monocarboxylate_transporter_1	0,29	short-chain fatty acids	Monocarboxylate transporter 1	MESH:D005232	509911(Tax:9913)	Chemical	Gene	transport|nmod|START_ENTITY mediates|dobj|transport mediates|nsubj|END_ENTITY	Monocarboxylate_transporter_1 -LRB- MCT1 -RRB- mediates transport of short-chain_fatty_acids in bovine caecum .
9757553	0	shoyuflavones	106,119	histidine_decarboxylase	59,82	shoyuflavones	histidine decarboxylase	null	15186(Tax:10090)	Chemical	Gene	activity|nmod|START_ENTITY END_ENTITY|dobj|activity	Novel histamine measurement by HPLC analysis used to assay histidine_decarboxylase inhibitory activity of shoyuflavones from soy sauce .
3154188	0	sialic_acid	20,31	C-reactive_protein	0,18	sialic acid	C-reactive protein	MESH:D019158	1401	Chemical	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	C-reactive_protein , sialic_acid and adenosine_deaminase levels in serum and pleural fluid from patients with pleural_effusion .
21919466	0	sialic_acid	22,33	DmSAS	0,5	sialic acid	DmSAS	MESH:D019158	41528(Tax:7227)	Chemical	Gene	biosynthesis|amod|START_ENTITY required|nmod|biosynthesis required|nsubjpass|END_ENTITY	DmSAS is required for sialic_acid biosynthesis in cultured Drosophila third instar larvae CNS neurons .
20032467	0	sialic_acid	90,101	M-ficolin	125,134	sialic acid	M-ficolin	MESH:D019158	2219	Chemical	Gene	specificity|amod|START_ENTITY specificity|nmod|END_ENTITY	Carbohydrate recognition properties of human ficolins : glycan array screening reveals the sialic_acid binding specificity of M-ficolin .
8111206	0	sialic_acid	67,78	NAG	116,119	sialic acid	NAG	MESH:D019158	10724	Chemical	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Relation between dampness-heat syndrome of glomerulonephritis and sialic_acid and N-acetyl-beta-D-glucosaminidase -LRB- NAG -RRB- -RSB- .
26378150	0	sialic_acid	113,124	NanS	49,53	sialic acid	NanS	MESH:D019158	540602(Tax:9913)	Chemical	Gene	START_ENTITY|nsubj|Characterization Characterization|appos|END_ENTITY	Characterization of a sialate O-acetyl esterase -LRB- NanS -RRB- from the oral pathogen Tannerella_forsythia that enhances sialic_acid release by NanH its cognate sialidase .
7231488	0	sialic_acid	32,43	Neuraminidase	0,13	sialic acid	Neuraminidase	MESH:D019158	4758	Chemical	Gene	START_ENTITY|nsubj|activity activity|amod|END_ENTITY	Neuraminidase activity and free sialic_acid levels in the serum of patients with acute_poststreptococcal_glomerulonephritis .
24748456	0	sialic_acid	49,60	SIAE	77,81	sialic acid	SIAE	MESH:D019158	54414	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A missense single-nucleotide polymorphism in the sialic_acid acetylesterase -LRB- SIAE -RRB- gene is associated with anti-PIT-1 antibody syndrome .
11358961	0	sialic_acid	51,62	Siglec-10	32,41	sialic acid	Siglec-10	MESH:D019158	89790	Chemical	Gene	START_ENTITY|nsubj|Cloning Cloning|nmod|END_ENTITY	Cloning and characterization of Siglec-10 , a novel sialic_acid binding member of the Ig superfamily , from human dendritic cells .
3470114	0	sialic_acid	48,59	alpha-L-fucosidase	0,18	sialic acid	alpha-L-fucosidase	MESH:D019158	11036	Chemical	Gene	START_ENTITY|nsubj|variant variant|amod|END_ENTITY	alpha-L-fucosidase variant and lipid-associated sialic_acid in hereditary_ovarian_cancer .
3738866	0	sialic_acid	25,36	fibrinogen	14,24	sialic acid	fibrinogen	MESH:D019158	2244	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|END_ENTITY	The effect of fibrinogen sialic_acid residues on ex vivo platelet deposition on biomaterials .
6205441	0	sialic_acid	54,65	fibrinogen	12,22	sialic acid	fibrinogen	MESH:D019158	2244	Chemical	Gene	content|amod|START_ENTITY END_ENTITY|nmod|content	An abnormal fibrinogen -LRB- Copenhagen II -RRB- with increased sialic_acid content associated with thrombotic tendency and normal liver function .
12487819	0	sialic_acid	25,36	gp120	40,45	sialic acid	gp120	MESH:D019158	3700	Chemical	Gene	START_ENTITY|nmod|binding binding|amod|END_ENTITY	High mannose glycans and sialic_acid on gp120 regulate binding of mannose-binding_lectin -LRB- MBL -RRB- to HIV_type_1 .
12477836	0	sialic_acid	157,168	hemagglutinin-neuraminidase	46,73	sialic acid	hemagglutinin-neuraminidase	MESH:D019158	911961(Tax:11216)	Chemical	Gene	START_ENTITY|nsubj|Mutations Mutations|nmod|END_ENTITY	Mutations in human_parainfluenza_virus_type_3 hemagglutinin-neuraminidase causing increased receptor binding activity and resistance to the transition state sialic_acid analog 4-GU-DANA -LRB- Zanamivir -RRB- .
3749868	0	sialic_acid	69,80	hepatic_binding_protein	93,116	sialic acid	hepatic binding protein	MESH:D019158	50865	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	1H NMR investigation of the binding of methyl-beta-D-galactoses with sialic_acid residues on hepatic_binding_protein -- the effect of divalent calcium ions .
3512542	0	sialic_acid	25,36	insulin_receptor	40,56	sialic acid	insulin receptor	MESH:D019158	3643	Chemical	Gene	START_ENTITY|nmod|function function|amod|END_ENTITY	The role of cell surface sialic_acid in insulin_receptor function and insulin action .
11421259	0	sialic_acid	9,20	neuraminidase	74,87	sialic acid	neuraminidase	MESH:D019158	4758	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Aromatic sialic_acid analogues as potential inhibitors of influenza virus neuraminidase .
1499147	0	sialic_acid	48,59	prolactin	20,29	sialic acid	prolactin	MESH:D019158	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|END_ENTITY	The effect of ovine prolactin on the epididymal sialic_acid concentration in male rats .
9740323	0	sialic_acid	8,19	prosaposin	42,52	sialic acid	prosaposin	MESH:D019158	25524(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|endocytosis endocytosis|nmod|END_ENTITY	Role of sialic_acid in the endocytosis of prosaposin by the nonciliated cells of the rat efferent ducts .
12359136	0	sialic_acid	46,57	sialin	105,111	sialic acid	sialin	MESH:D019158	26503	Chemical	Gene	disorders|amod|START_ENTITY pathogenesis|nmod|disorders Unraveling|dobj|pathogenesis Unraveling|dep|altered altered|nmod|END_ENTITY	Unraveling the molecular pathogenesis of free sialic_acid storage disorders : altered targeting of mutant sialin .
25494612	0	sialic_acid	57,68	sialin	37,43	sialic acid	sialin	MESH:D019158	26503	Chemical	Gene	transporter|amod|START_ENTITY END_ENTITY|appos|transporter	Autophagy regulates the stability of sialin , a lysosomal sialic_acid transporter .
15242781	0	sialic_acids	68,80	ST8SiaII	46,54	sialic acids	ST8SiaII	MESH:D012794	8128	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Selective inhibition of polysialyltransferase ST8SiaII by unnatural sialic_acids .
3217921	0	sialic_acids	35,47	protein_C	80,89	sialic acids	protein C	MESH:D012794	5624	Chemical	Gene	START_ENTITY|nmod|properties properties|nmod|END_ENTITY	The effect of enzymatic removal of sialic_acids on the functional properties of protein_C .
857425	0	sialosylparagloboside	18,39	erythrocyte_receptor	47,67	sialosylparagloboside	erythrocyte receptor	MESH:C014812	914	Chemical	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of sialosylparagloboside as the erythrocyte_receptor for an ` anti-p ' antibody .
1281620	0	sialyl-Lewis_X	14,28	E-selectin	33,43	sialyl-Lewis X	E-selectin	MESH:C086527	6401	Chemical	Gene	START_ENTITY|appos|ligand ligand|amod|END_ENTITY	Expression of sialyl-Lewis_X , an E-selectin ligand , in inflammation , immune processes , and lymphoid tissues .
8917642	2	sialyl_Lewis_X	73,87	P-selectin	108,118	sialyl Lewis X	P-selectin	MESH:C086527	6403	Chemical	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Investigation of the carbohydrate ligand sialyl_Lewis_X recognition site of P-selectin .
10806602	0	sibrafiban	41,51	GP_IIb	76,82	sibrafiban	GP IIb	MESH:C100917	3674	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Pharmacokinetics and pharmacodynamics of sibrafiban , an orally administered GP_IIb / IIIa antagonist , following coadministration of aspirin and heparin .
20456197	0	sibutramine	16,27	brain_natriuretic_peptide	36,61	sibutramine	brain natriuretic peptide	MESH:C058254	4879	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|levels levels|amod|END_ENTITY	An obesity drug sibutramine reduces brain_natriuretic_peptide -LRB- BNP -RRB- levels in severely obese patients .
20720348	0	sibutramine	40,51	insulin	61,68	sibutramine	insulin	MESH:C058254	3630	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	Sibutramine and L-carnitine compared to sibutramine alone on insulin resistance in diabetic patients .
19890256	0	sibutramine	46,57	serotonin_transporter	6,27	sibutramine	serotonin transporter	MESH:C058254	6532	Chemical	Gene	occupancy|nmod|START_ENTITY occupancy|compound|END_ENTITY	Brain serotonin_transporter occupancy by oral sibutramine dosed to steady state : a PET study using -LRB- 11 -RRB- C-DASB in healthy humans .
16671551	0	sibutramine_hydrochloride	41,66	albumin	84,91	sibutramine hydrochloride	albumin	MESH:C058254	213	Chemical	Gene	-RSB-|amod|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Spectroscopic studies on the binding of sibutramine_hydrochloride and bovine serum albumin -RSB- .
19660688	0	sildenafil	152,162	B-type_natriuretic_peptide	15,41	sildenafil	B-type natriuretic peptide	MESH:C101426	4879	Chemical	Gene	effects|nmod|START_ENTITY release|dep|effects release|amod|END_ENTITY	Transpulmonary B-type_natriuretic_peptide uptake and cyclic_guanosine_monophosphate release in heart_failure and pulmonary_hypertension : the effects of sildenafil .
26816265	0	sildenafil	47,57	C-type_natriuretic_peptide	0,26	sildenafil	C-type natriuretic peptide	MESH:C101426	4880	Chemical	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	C-type_natriuretic_peptide in combination with sildenafil attenuates proliferation of rhabdomyosarcoma cells .
16741028	0	sildenafil	11,21	ET-1	62,66	sildenafil	ET-1	MESH:C101426	24323(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of sildenafil on pulmonary_hypertension and levels of ET-1 , eNOS , and cGMP in aorta-banded rats .
12435622	0	sildenafil	86,96	PDE-5	69,74	sildenafil	PDE-5	MESH:C101426	8654	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Erectile_dysfunction : comparison of efficacy and side effects of the PDE-5 inhibitors sildenafil , vardenafil and tadalafil -- review of the literature .
15452368	0	sildenafil	41,51	PDE-5	25,30	sildenafil	PDE-5	MESH:C101426	242202(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|inhibitor inhibitor|compound|END_ENTITY	Modulatory effect of the PDE-5 inhibitor sildenafil in diabetic_neuropathy .
24996004	0	sildenafil	124,134	PDE-5	41,46	sildenafil	PDE-5	MESH:C101426	8654	Chemical	Gene	using|dobj|START_ENTITY inhibitors|advcl|using inhibitors|nsubj|analysis analysis|nmod|END_ENTITY	Qualitative and quantitative analysis of PDE-5 inhibitors in counterfeit medicines and dietary supplements by HPLC-UV using sildenafil as a sole reference .
11707698	0	sildenafil	54,64	PDE5	68,72	sildenafil	PDE5	MESH:C101426	403825(Tax:9615)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Cardiac electrophysiologic and hemodynamic effects of sildenafil , a PDE5 inhibitor , in anesthetized dogs .
15175637	0	sildenafil	26,36	PDE5	152,156	sildenafil	PDE5	MESH:C101426	8654	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|phosphodiesterase phosphodiesterase|appos|END_ENTITY	Cardiovascular effects of sildenafil in hypertensive men with erectile_dysfunction and different alleles of the type 5 cGMP-specific phosphodiesterase -LRB- PDE5 -RRB- .
15312980	0	sildenafil	53,63	PDE5	113,117	sildenafil	PDE5	MESH:C101426	8654	Chemical	Gene	START_ENTITY|nmod|phosphodiesterase-5 phosphodiesterase-5|appos|END_ENTITY	Vardenafil : structural basis for higher potency over sildenafil in inhibiting cGMP-specific phosphodiesterase-5 -LRB- PDE5 -RRB- .
16076505	0	sildenafil	30,40	PDE5	14,18	sildenafil	PDE5	MESH:C101426	242202(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	The selective PDE5 inhibitor , sildenafil , improves object memory in Swiss mice and increases cGMP levels in hippocampal slices .
16281046	0	sildenafil	72,82	PDE5	16,20	sildenafil	PDE5	MESH:C101426	8654	Chemical	Gene	contributes|nmod|START_ENTITY contributes|nsubj|Tyrosine-612 Tyrosine-612|nmod|END_ENTITY	Tyrosine-612 in PDE5 contributes to higher affinity for vardenafil over sildenafil .
17102958	0	sildenafil	36,46	PDE5	20,24	sildenafil	PDE5	MESH:C101426	8654	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nummod|END_ENTITY	In vitro effects of PDE5 inhibitors sildenafil , vardenafil and tadalafil on isolated human ureteral smooth muscle : a basic research approach .
21036891	0	sildenafil	21,31	PDE5	0,4	sildenafil	PDE5	MESH:C101426	8654	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nummod|END_ENTITY	PDE5 inhibition with sildenafil improves left ventricular diastolic function , cardiac geometry , and clinical status in patients with stable systolic heart_failure : results of a 1-year , prospective , randomized , placebo-controlled study .
21193396	0	sildenafil	114,124	PDE5	93,97	sildenafil	PDE5	MESH:C101426	8654	Chemical	Gene	induced|nmod|START_ENTITY induced|nmod|phosphodiesterase phosphodiesterase|appos|END_ENTITY	Distinct allostery induced in the cyclic_GMP-binding , cyclic_GMP-specific phosphodiesterase -LRB- PDE5 -RRB- by cyclic_GMP , sildenafil , and metal ions .
21620965	0	sildenafil	53,63	PDE5	29,33	sildenafil	PDE5	MESH:C101426	8654	Chemical	Gene	ion|compound|START_ENTITY incubation|nmod|ion END_ENTITY|nmod|incubation	Conformational conversion of PDE5 by incubation with sildenafil or metal ion is accompanied by stimulation of allosteric cGMP binding .
22578167	0	sildenafil	17,27	PDE5	0,4	sildenafil	PDE5	MESH:C101426	8654	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nummod|END_ENTITY	PDE5 inhibitors , sildenafil and vardenafil , reverse multidrug resistance by inhibiting the efflux function of multidrug_resistance_protein_7 -LRB- ATP-binding Cassette C10 -RRB- transporter .
24448333	0	sildenafil	56,66	PDE5	40,44	sildenafil	PDE5	MESH:C101426	8654	Chemical	Gene	inhibitor|dep|START_ENTITY inhibitor|compound|END_ENTITY	VICTORY project : a study of counterfeit PDE5 inhibitor -LRB- sildenafil -RRB- in Indonesia .
22067410	0	sildenafil	36,46	Phosphodiesterase_5	0,19	sildenafil	Phosphodiesterase 5	MESH:C101426	8654	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Phosphodiesterase_5 inhibition with sildenafil reverses exercise oscillatory breathing in chronic heart_failure : a long-term cardiopulmonary exercise testing placebo-controlled study .
18036727	0	sildenafil	21,31	insulin	108,115	sildenafil	insulin	MESH:C101426	3630	Chemical	Gene	treatment|nmod|START_ENTITY reverses|nsubj|treatment reverses|nmod|model model|nmod|resistance resistance|compound|END_ENTITY	Daily treatment with sildenafil reverses endothelial_dysfunction and oxidative stress in an animal model of insulin resistance .
22016348	0	sildenafil	25,35	insulin	105,112	sildenafil	insulin	MESH:C101426	3630	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	Addition of metformin to sildenafil treatment for erectile_dysfunction in eugonadal nondiabetic men with insulin resistance .
15223851	0	sildenafil	108,118	pde-5	77,82	sildenafil	pde-5	MESH:C101426	8654	Chemical	Gene	study|nmod|START_ENTITY changes|dep|study changes|nmod|patients patients|nmod|erectile_dysfunction erectile_dysfunction|acl|using using|dobj|inhibitors inhibitors|amod|END_ENTITY	Cardiovascular parameter changes in patients with erectile_dysfunction using pde-5 inhibitors : a study with sildenafil and vardenafil .
15607396	0	sildenafil	51,61	phosphodiesterase-5	15,34	sildenafil	phosphodiesterase-5	MESH:C101426	8654	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	The effects of phosphodiesterase-5 inhibition with sildenafil on pulmonary hemodynamics and diffusion capacity , exercise ventilatory efficiency , and oxygen uptake kinetics in chronic_heart_failure .
16926278	0	sildenafil	102,112	phosphodiesterase-5	27,46	sildenafil	phosphodiesterase-5	MESH:C101426	8654	Chemical	Gene	potency|nmod|START_ENTITY provides|nmod|potency provides|nsubj|segment segment|nmod|domain domain|amod|END_ENTITY	A 46-amino_acid segment in phosphodiesterase-5 GAF-B domain provides for high vardenafil potency over sildenafil and tadalafil and is involved in phosphodiesterase-5 dimerization .
17127429	0	sildenafil	89,99	phosphodiesterase-5	19,38	sildenafil	phosphodiesterase-5	MESH:C101426	8654	Chemical	Gene	induced|advcl|START_ENTITY change|acl|induced promoted|nmod|change promoted|nsubjpass|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation of phosphodiesterase-5 is promoted by a conformational change induced by sildenafil , vardenafil , or tadalafil .
17553682	0	sildenafil	19,29	phosphodiesterase_5	51,70	sildenafil	phosphodiesterase 5	MESH:C101426	8654	Chemical	Gene	analogues|amod|START_ENTITY analogues|appos|END_ENTITY	3D-QSAR studies on sildenafil analogues , selective phosphodiesterase_5 inhibitors .
23911424	0	sildenafil	75,85	phosphodiesterase_5	45,64	sildenafil	phosphodiesterase 5	MESH:C101426	242202(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Gender-specific immunological effects of the phosphodiesterase_5 inhibitor sildenafil in healthy mice .
12127092	0	sildenafil	62,72	phosphodiesterase_type_5	25,49	sildenafil	phosphodiesterase type 5	MESH:C101426	171115(Tax:10116)	Chemical	Gene	Effects|amod|START_ENTITY Effects|nmod|inhibitors inhibitors|amod|END_ENTITY	Effects of two selective phosphodiesterase_type_5 inhibitors , sildenafil and vardenafil , on object recognition memory and hippocampal cyclic_GMP levels in the rat .
16204472	0	sildenafil	64,74	phosphodiesterase_type_5	28,52	sildenafil	phosphodiesterase type 5	MESH:C101426	171115(Tax:10116)	Chemical	Gene	inhibitors|dobj|START_ENTITY inhibitors|nsubj|effects effects|nmod|END_ENTITY	Differential effects of the phosphodiesterase_type_5 inhibitors sildenafil , vardenafil , and tadalafil in rat aorta .
17137237	0	sildenafil	38,48	phosphodiesterase_type_5	60,84	sildenafil	phosphodiesterase type 5	MESH:C101426	8654	Chemical	Gene	switching|nmod|START_ENTITY switching|nmod|inhibitor inhibitor|amod|END_ENTITY	The economic effect of switching from sildenafil to another phosphodiesterase_type_5 inhibitor .
22359075	0	sildenafil	63,73	phosphodiesterase_type_5	27,51	sildenafil	phosphodiesterase type 5	MESH:C101426	171115(Tax:10116)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Chronic treatment with the phosphodiesterase_type_5 inhibitors sildenafil and tadalafil display anxiolytic effects in Flinders Sensitive Line rats .
12192104	0	sildenafil	10,20	renin	24,29	sildenafil	renin	MESH:C101426	5972	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of sildenafil on renin secretion in human subjects .
22736024	0	silibinin	21,30	EGFR	34,38	silibinin	EGFR	MESH:C440975	1956	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|progression progression|amod|END_ENTITY	Inhibitory effect of silibinin on EGFR signal-induced renal_cell_carcinoma progression via suppression of the EGFR/MMP -9 signaling pathway .
23396055	0	silibinin	16,25	IGF-1R	31,37	silibinin	IGF-1R	MESH:C440975	3480	Chemical	Gene	START_ENTITY|nmod|pathways pathways|compound|END_ENTITY	Interference of silibinin with IGF-1R signalling pathways protects human epidermoid_carcinoma A431 cells from UVB-induced apoptosis .
22283740	0	silibinin	39,48	P53	0,3	silibinin	P53	MESH:C440975	7157	Chemical	Gene	generation|amod|START_ENTITY role|nmod|generation plays|dobj|role plays|nsubj|activation activation|compound|END_ENTITY	P53 activation plays a crucial role in silibinin induced ROS generation via PUMA and JNK .
10895987	0	silibinin	22,31	cytochrome_P-450	35,51	silibinin	cytochrome P-450	MESH:C440975	4051	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|enzymes enzymes|amod|END_ENTITY	Inhibitory effects of silibinin on cytochrome_P-450 enzymes in human liver microsomes .
20398679	0	silibinin	64,73	nuclear_factor-kappa_B	18,40	silibinin	nuclear factor-kappa B	MESH:C440975	4790	Chemical	Gene	pathway|nmod|START_ENTITY pathway|amod|END_ENTITY	Downregulation of nuclear_factor-kappa_B -LRB- NF-kappaB -RRB- pathway by silibinin in human monocytes challenged with Paracoccidioides_brasiliensis .
17938263	0	silibinin	25,34	p21	0,3	silibinin	p21	MESH:C440975	644914	Chemical	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	p21 and p27 induction by silibinin is essential for its cell cycle arrest effect in prostate_carcinoma cells .
26447614	6	silibinin	1096,1105	p53	1131,1134	silibinin	XPA	MESH:C440975	7507	Chemical	Gene	treatment|compound|START_ENTITY increased|nsubj|treatment increased|dobj|expression expression|compound|END_ENTITY	In UVB exposed fibroblasts , silibinin treatment also increased p53 and GADD45a expression ; the key regulators of the NER pathway and DNA repair .
15076315	0	silibinin	80,89	prostate_specific_antigen	51,76	silibinin	prostate specific antigen	MESH:C440975	354	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of telomerase activity and secretion of prostate_specific_antigen by silibinin in prostate_cancer cells .
3508451	0	silibinin	10,19	superoxide_dismutase	54,74	silibinin	superoxide dismutase	MESH:C440975	6647	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|nmod|END_ENTITY	Effect of silibinin on the activity and expression of superoxide_dismutase in lymphocytes from patients with chronic alcoholic_liver_disease .
17575405	0	silica	90,96	EC-SOD	27,33	silica	EC-SOD	MESH:D012822	25352(Tax:10116)	Chemical	Gene	exposed|nmod|START_ENTITY exposed|nsubj|expression expression|nmod|END_ENTITY	Differential expression of EC-SOD , Mn-SOD and CuZn-SOD in rat lung exposed to crystalline silica .
17181938	0	silica	73,79	FasL	15,19	silica	FasL	MESH:D012822	25385(Tax:10116)	Chemical	Gene	exposed|nmod|START_ENTITY exposed|nsubj|Expression Expression|nmod|END_ENTITY	-LSB- Expression of FasL and apoptosis in pulmonary tissue of rats exposed to silica at different time -RSB- .
25841781	0	silica	125,131	Hsp70	187,192	silica	Hsp70	MESH:D012822	3308	Chemical	Gene	START_ENTITY|nmod|mechanism mechanism|nmod|END_ENTITY	Peroxynitrite-mediated glyoxalase_I epigenetic inhibition drives apoptosis in airway epithelial cells exposed to crystalline silica via a novel mechanism involving argpyrimidine-modified Hsp70 , JNK , and NF-kB .
16984918	0	silica	15,21	MARCO	0,5	silica	MARCO	MESH:D012822	17167(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY mediates|dobj|uptake mediates|nsubj|END_ENTITY	MARCO mediates silica uptake and toxicity in alveolar macrophages from C57BL/6 mice .
25565800	0	silica	60,66	NF-kB	89,94	silica	NF-kB	MESH:D012822	309165(Tax:10116)	Chemical	Gene	nanoparticles|compound|START_ENTITY nanoparticles|nmod|END_ENTITY	Renal_interstitial_fibrosis induced by high-dose mesoporous silica nanoparticles via the NF-kB signaling pathway .
10934113	0	silica	47,53	Vitronectin	0,11	silica	Vitronectin	MESH:D012822	29169(Tax:10116)	Chemical	Gene	toxicity|compound|START_ENTITY protects|nmod|toxicity protects|nsubj|END_ENTITY	Vitronectin protects alveolar macrophages from silica toxicity .
9013861	0	silica	14,20	carbonic_anhydrase_II	44,65	silica	carbonic anhydrase II	MESH:D012822	760	Chemical	Gene	nanoparticles|compound|START_ENTITY nanoparticles|nmod|END_ENTITY	Adsorption to silica nanoparticles of human carbonic_anhydrase_II and truncated forms induce a molten-globule-like structure .
16370310	0	silica	59,65	cyclinD1	8,16	silica	cyclinD1	MESH:D012822	595	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Role Role|nmod|END_ENTITY	Role of cyclinD1 and CDK4 in the carcinogenesis induced by silica .
6100955	0	silica	61,67	erythropoietin	11,25	silica	erythropoietin	MESH:D012822	13856(Tax:10090)	Chemical	Gene	Release|nmod|START_ENTITY Release|nmod|END_ENTITY	Release of erythropoietin from macrophages by treatment with silica .
16612041	0	silica	75,81	heme_oxygenase-1	14,30	silica	heme oxygenase-1	MESH:D012822	24451(Tax:10116)	Chemical	Gene	exposed|nmod|START_ENTITY exposed|nsubj|Expression Expression|nmod|END_ENTITY	Expression of heme_oxygenase-1 in the lungs of rats exposed to crystalline silica .
23517533	0	silica	73,79	insulin	95,102	silica	insulin	MESH:D012822	3630	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	A pH gated , glucose-sensitive nanoparticle based on worm-like mesoporous silica for controlled insulin release .
12460731	0	silica	102,108	interferon-gamma	8,24	silica	interferon-gamma	MESH:D012822	15978(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Role Role|nmod|END_ENTITY	Role of interferon-gamma in the development of murine bronchus-associated lymphoid tissues induced by silica in vivo .
9448045	0	silica	47,53	interleukin-10	8,22	silica	interleukin-10	MESH:D012822	16153(Tax:10090)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of interleukin-10 in the lung response to silica in mice .
21456224	0	silicon	46,53	C-reactive_protein	21,39	silicon	C-reactive protein	MESH:D012825	1401	Chemical	Gene	using|dobj|START_ENTITY END_ENTITY|acl|using	In-situ detection of C-reactive_protein using silicon nanowire field effect transistor .
18980663	0	silicon	12,19	HvLsi1	0,6	silicon	HvLsi1	MESH:D012825	100301576(Tax:4513)	Chemical	Gene	transporter|compound|START_ENTITY transporter|nsubj|END_ENTITY	HvLsi1 is a silicon influx transporter in barley .
16907469	0	silicon	32,39	Spin	0,4	silicon	Spin	MESH:D012825	10927	Chemical	Gene	injection|nmod|START_ENTITY injection|compound|END_ENTITY	Spin injection and detection in silicon .
24727686	0	silicon	47,54	Spin	0,4	silicon	Spin	MESH:D012825	10927	Chemical	Gene	blockade|nmod|START_ENTITY blockade|compound|END_ENTITY	Spin blockade and exchange in Coulomb-confined silicon double quantum dots .
26089110	0	silicon	35,42	Spin	0,4	silicon	Spin	MESH:D012825	10927	Chemical	Gene	transport|nmod|START_ENTITY transport|amod|END_ENTITY	Spin transport and Hanle effect in silicon nanowires using graphene tunnel barriers .
16011845	0	silicon	77,84	osteopontin	52,63	silicon	osteopontin	MESH:D012825	6696	Chemical	Gene	affinity|nmod|START_ENTITY affinity|compound|END_ENTITY	Functional atomic force microscopy investigation of osteopontin affinity for silicon stabilized tricalcium_phosphate bioceramic surfaces .
23023645	0	silicon	35,42	spin	15,19	silicon	spin	MESH:D012825	10927	Chemical	Gene	injection|nmod|START_ENTITY injection|compound|END_ENTITY	Low-resistance spin injection into silicon using graphene tunnel barriers .
27061103	0	silodosin	11,20	alpha-1A_adrenoceptor	34,55	silodosin	alpha-1A adrenoceptor	MESH:C095285	29412(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Effects of silodosin , a selective alpha-1A_adrenoceptor antagonist , on erectile function in a rat model of partial bladder_outlet_obstruction .
20080287	0	silodosin	39,48	alpha1a-adrenoceptor	69,89	silodosin	alpha1a-adrenoceptor	MESH:C095285	148	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Lack of pharmacodynamic interaction of silodosin , a highly selective alpha1a-adrenoceptor antagonist , with the phosphodiesterase-5 inhibitors sildenafil and tadalafil in healthy men .
19220259	0	silodosin	32,41	alpha_1A-adrenoceptor	55,76	silodosin	alpha 1A-adrenoceptor	MESH:C095285	29412(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|antagonist antagonist|amod|END_ENTITY	Short - and long-term effects of silodosin , a selective alpha_1A-adrenoceptor antagonist , on ejaculatory function in rats .
19693954	0	silodosin	22,31	alpha_1A-adrenoceptor	39,60	silodosin	alpha 1A-adrenoceptor	MESH:C095285	148	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Urodynamic effects of silodosin , a new alpha_1A-adrenoceptor selective antagonist , for the treatment of benign_prostatic_hyperplasia .
21211286	0	siltuximab	12,22	interleukin-6	30,43	siltuximab	interleukin-6	null	3569	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of siltuximab on the interleukin-6 / Stat3 signaling pathway in ovarian_cancer -RSB- .
26650280	0	silver	41,47	ClP	84,87	silver	ClP	MESH:D012834	810	Chemical	Gene	complex|compound|START_ENTITY complex|nmod|END_ENTITY	Low temperature isolation of a dinuclear silver complex of the cyclotetraphosphane -LSB- ClP -LRB- - PMes * -RRB- -RSB- 2 .
20569931	0	silver	16,22	Ctr1	0,4	silver	Ctr1	MESH:D012834	1317	Chemical	Gene	transports|dobj|START_ENTITY transports|nsubj|END_ENTITY	Ctr1 transports silver into mammalian cells .
16760433	0	silver	87,93	Pmel17	106,112	silver	Pmel17	MESH:D012834	20431(Tax:10090)	Chemical	Gene	mutation|amod|START_ENTITY mutation|nmod|END_ENTITY	Dual loss of ER export and endocytic signals with altered melanosome morphology in the silver mutation of Pmel17 .
19167270	0	silver	88,94	S-Ag	31,35	silver	S-Ag	MESH:D012834	6295	Chemical	Gene	interaction|nmod|START_ENTITY interaction|amod|END_ENTITY	Spectroscopic investigation of S-Ag interaction in omega-mercaptoundecanoic_acid capped silver nanoparticles .
17257181	0	silver	46,52	SILV	16,20	silver	SILV	MESH:D012834	100033885(Tax:9796)	Chemical	Gene	colour|amod|START_ENTITY associated|nmod|colour associated|nsubjpass|SNPs SNPs|nmod|gene gene|compound|END_ENTITY	Two SNPs in the SILV gene are associated with silver coat colour in ponies .
17892572	0	silver	43,49	SILV	61,65	silver	SILV	MESH:D012834	281487(Tax:9913)	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Multiple splice variants within the bovine silver homologue -LRB- SILV -RRB- gene affecting coat color in cattle indicate a function additional to fibril formation in melanophores .
20183284	0	silybin	14,21	CA1	92,95	silybin	CA1	MESH:C440975	310218(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of silybin on passive avoidance learning and pathological changes in hippocampal CA1 and DG regions in male Wistar_rats offspring .
24203891	0	silylamines	48,59	CO2	74,77	silylamines	CO2	null	717	Chemical	Gene	START_ENTITY|nmod|capture capture|compound|END_ENTITY	Design , synthesis , and evaluation of nonaqueous silylamines for efficient CO2 capture .
26750777	0	silylimido	23,33	CO2	0,3	silylimido	CO2	null	717	Chemical	Gene	activation|nmod|START_ENTITY activation|nummod|END_ENTITY	CO2 activation through silylimido and silylamido_zirconium_hydrides supported on N-donor chelating SBA15 surface ligands .
8292974	0	silymarin	47,56	SOD	82,85	silymarin	SOD	MESH:D012838	6647	Chemical	Gene	START_ENTITY|nmod|activity activity|appos|END_ENTITY	Effect of the natural bioflavonoid antioxidant silymarin on superoxide_dismutase -LRB- SOD -RRB- activity and expression in vitro .
12065710	0	silymarin	60,69	inducible_nitric-oxide_synthase	14,45	silymarin	inducible nitric-oxide synthase	MESH:D012838	18126(Tax:10090)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|expression expression|amod|END_ENTITY	Inhibition of inducible_nitric-oxide_synthase expression by silymarin in lipopolysaccharide-stimulated macrophages .
8020140	0	silymarin	21,30	ornithine_decarboxylase	121,144	silymarin	ornithine decarboxylase	MESH:D012838	18263(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nsubj|effect	Inhibitory effect of silymarin , an anti-hepatotoxic flavonoid , on 12-O-tetradecanoylphorbol-13-acetate-induced epidermal ornithine_decarboxylase activity and mRNA in SENCAR mice .
17620219	0	silymarin	25,34	peroxisome_proliferator-activated_receptor_alpha	59,107	silymarin	peroxisome proliferator-activated receptor alpha	MESH:D012838	25747(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY mediated|nsubjpass|effects mediated|nmod|END_ENTITY	Hypolipidemic effects of silymarin are not mediated by the peroxisome_proliferator-activated_receptor_alpha .
8292974	0	silymarin	47,56	superoxide_dismutase	60,80	silymarin	superoxide dismutase	MESH:D012838	6647	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effect of the natural bioflavonoid antioxidant silymarin on superoxide_dismutase -LRB- SOD -RRB- activity and expression in vitro .
9772703	0	silymarin	11,20	tumor_necrosis_factor	71,92	silymarin	tumor necrosis factor	MESH:D012838	21926(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Effect of silymarin on mouse liver_damage , production and activity of tumor_necrosis_factor -RSB- .
18687803	0	silymarin_flavonolignans	44,68	multidrug_resistance-associated_protein_2	110,151	silymarin flavonolignans	multidrug resistance-associated protein 2	null	25303(Tax:10116)	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|dep|role role|nmod|END_ENTITY	Hepatic metabolism and biliary excretion of silymarin_flavonolignans in isolated perfused rat livers : role of multidrug_resistance-associated_protein_2 -LRB- Abcc2 -RRB- .
24060488	0	simocyclinone_D8	56,72	DNA_gyrase	76,86	simocyclinone D8	DNA gyrase	MESH:C416814	7153	Chemical	Gene	inspired|nmod|START_ENTITY inspired|nmod|inhibitors inhibitors|compound|END_ENTITY	Flavone-based analogues inspired by the natural product simocyclinone_D8 as DNA_gyrase inhibitors .
24594357	0	simocyclinone_D8	55,71	DNA_gyrase	81,91	simocyclinone D8	DNA gyrase	MESH:C416814	7153	Chemical	Gene	START_ENTITY|acl|bound bound|nmod|END_ENTITY	A new crystal structure of the bifunctional antibiotic simocyclinone_D8 bound to DNA_gyrase gives fresh insight into the mechanism of inhibition .
2022360	0	simvastatin	22,33	3-hydroxy-3-methylglutaryl_coenzyme_A_reductase	62,109	simvastatin	3-hydroxy-3-methylglutaryl coenzyme A reductase	MESH:D019821	100357791(Tax:9986)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	-LSB- Preventive effect of simvastatin , a competitive inhibitor of 3-hydroxy-3-methylglutaryl_coenzyme_A_reductase , on coronary_atherosclerosis in cholesterol-fed rabbits -RSB- .
2742865	0	simvastatin	19,30	3-hydroxy-3-methylglutaryl_coenzyme_A_reductase	49,96	simvastatin	3-hydroxy-3-methylglutaryl coenzyme A reductase	MESH:D019821	100357791(Tax:9986)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Effects of MK-733 -LRB- simvastatin -RRB- , an inhibitor of 3-hydroxy-3-methylglutaryl_coenzyme_A_reductase , on intestinal acylcoenzyme A : cholesterol acyltransferase activity in rabbits .
17157514	0	simvastatin	77,88	Bcl-2	0,5	simvastatin	Bcl-2	MESH:D019821	100733337	Chemical	Gene	treatment|compound|START_ENTITY brain|nmod|treatment guinea_pig|dobj|brain upregulation|advcl|guinea_pig upregulation|nsubj|END_ENTITY	Bcl-2 upregulation and neuroprotection in guinea_pig brain following chronic simvastatin treatment .
25582208	0	simvastatin	11,22	Bcl-2	34,39	simvastatin	Bcl-2	MESH:D019821	24224(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of simvastatin on retinal Bcl-2 / Bax expression and cell apoptosis in rats with ischemia-reperfusion injury -RSB- .
11472751	0	simvastatin	80,91	C-reactive_protein	0,18	simvastatin	C-reactive protein	MESH:D019821	1401	Chemical	Gene	therapy|compound|START_ENTITY effect|nmod|therapy END_ENTITY|dep|effect	C-reactive_protein in patients with familial_hypercholesterolemia : no effect of simvastatin therapy .
12398959	0	simvastatin	11,22	C-reactive_protein	26,44	simvastatin	C-reactive protein	MESH:D019821	1401	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of simvastatin on C-reactive_protein in mixed hyperlipidemic and hypertriglyceridemic patients .
14715352	0	simvastatin	10,21	C-reactive_protein	31,49	simvastatin	C-reactive protein	MESH:D019821	1401	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of simvastatin on serum C-reactive_protein during hormone replacement therapy .
16999946	0	simvastatin	53,64	C-reactive_protein	13,31	simvastatin	C-reactive protein	MESH:D019821	1401	Chemical	Gene	Reduction|nmod|START_ENTITY Reduction|nmod|END_ENTITY	Reduction of C-reactive_protein by a single 80 mg of simvastatin in patients with unstable_angina .
17145229	0	simvastatin	49,60	C-reactive_protein	15,33	simvastatin	C-reactive protein	MESH:D019821	1401	Chemical	Gene	therapy|compound|START_ENTITY course|nmod|therapy course|nmod|reduction reduction|amod|END_ENTITY	Time course of C-reactive_protein reduction with simvastatin therapy in patients with type_2_diabetes_mellitus .
17560879	0	simvastatin	54,65	C-reactive_protein	98,116	simvastatin	C-reactive protein	MESH:D019821	1401	Chemical	Gene	Comparison|nmod|START_ENTITY Comparison|acl|reducing reducing|dobj|levels levels|compound|END_ENTITY	Comparison of effects of ezetimibe/simvastatin versus simvastatin versus atorvastatin in reducing C-reactive_protein and low-density lipoprotein cholesterol levels .
18219956	0	simvastatin	37,48	C-reactive_protein	52,70	simvastatin	C-reactive protein	MESH:D019821	1401	Chemical	Gene	application|nmod|START_ENTITY effects|nmod|application -LSB-|dobj|effects -LSB-|nmod|level level|amod|END_ENTITY	-LSB- The effects of early application of simvastatin on C-reactive_protein level , blood lipids , and the clinical course of acute_coronary_syndrome -RSB- .
19195502	0	simvastatin	65,76	C-reactive_protein	89,107	simvastatin	C-reactive protein	MESH:D019821	1401	Chemical	Gene	Effect|nmod|START_ENTITY Effect|acl|lowering lowering|dobj|END_ENTITY	Effect of beta blockers -LRB- metoprolol or propranolol -RRB- on effect of simvastatin in lowering C-reactive_protein in acute myocardial_infarction .
20805273	0	simvastatin	48,59	C-reactive_protein	63,81	simvastatin	C-reactive protein	MESH:D019821	1401	Chemical	Gene	compared|nmod|START_ENTITY compared|nmod|concentrations concentrations|amod|END_ENTITY	Disparate effects of atorvastatin compared with simvastatin on C-reactive_protein concentrations in patients with type 2 diabetes .
23013513	0	simvastatin	11,22	C-reactive_protein	75,93	simvastatin	C-reactive protein	MESH:D019821	1401	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of simvastatin and ezetimibe on interleukin-6 and high-sensitivity C-reactive_protein .
16978784	0	simvastatin	22,33	CC_chemokine_ligand_5	75,96	simvastatin	CC chemokine ligand 5	MESH:D019821	6352	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Suppressive effect of simvastatin on interferon-beta-induced expression of CC_chemokine_ligand_5 in microglia .
20936727	0	simvastatin	12,23	CTGF	41,45	simvastatin	CTGF	MESH:D019821	64032(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of simvastatin on expression of CTGF and a-SMA in renal tubulointerstitium of rats with diabetic_nephropathy -RSB- .
18359719	0	simvastatin	11,22	CX3CR1	35,41	simvastatin	CX3CR1	MESH:D019821	1524	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	-LSB- Effect of simvastatin on monocyte CX3CR1 expression in patients with acute_coronary_syndrome -RSB- .
11753271	0	simvastatin	90,101	CYP2D6	46,52	simvastatin	CYP2D6	MESH:D019821	1565	Chemical	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of polymorphism in the cytochrome CYP2D6 and the efficacy and tolerability of simvastatin .
17192506	0	simvastatin	57,68	CYP3A5	22,28	simvastatin	CYP3A5	MESH:D019821	1577	Chemical	Gene	genotype|nmod|START_ENTITY genotype|compound|END_ENTITY	Effect of polymorphic CYP3A5 genotype on the single-dose simvastatin pharmacokinetics in healthy subjects .
15298857	0	simvastatin	108,119	Connective_tissue_growth_factor	0,31	simvastatin	Connective tissue growth factor	MESH:D019821	1490	Chemical	Gene	abrogated|nmod|START_ENTITY abrogated|nsubjpass|expression expression|compound|END_ENTITY	Connective_tissue_growth_factor expression and induction by transforming_growth_factor-beta is abrogated by simvastatin via a Rho signaling mechanism .
11165973	0	simvastatin	25,36	Fibrinogen	0,10	simvastatin	Fibrinogen	MESH:D019821	2244	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Fibrinogen response with simvastatin versus atorvastatin in familial_hypercholesterolemia .
23208905	0	simvastatin	68,79	G-CSF	57,62	simvastatin	G-CSF	MESH:D019821	25610(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Enhanced neuroprotective effects of co-administration of G-CSF with simvastatin on intracerebral_hemorrhage in rats .
23496027	0	simvastatin	82,93	GLUT4	42,47	simvastatin	GLUT4	MESH:D019821	6517	Chemical	Gene	induced|nmod|START_ENTITY expression|acl|induced expression|compound|END_ENTITY	Coenzyme_Q10 ameliorates the reduction in GLUT4 transporter expression induced by simvastatin in 3T3-L1 adipocytes .
10732848	0	simvastatin	85,96	HMG-CoA_reductase	56,73	simvastatin	HMG-CoA reductase	MESH:D019821	3156	Chemical	Gene	Effect|appos|START_ENTITY Effect|nmod|treatment treatment|nmod|inhibitor inhibitor|amod|END_ENTITY	Effect of long-term cholesterol-lowering treatment with HMG-CoA_reductase inhibitor -LRB- simvastatin -RRB- on myocardial perfusion evaluated by thallium-201 single photon emission computed tomography .
1352930	0	simvastatin	56,67	HMG-CoA_reductase	71,88	simvastatin	HMG-CoA reductase	MESH:D019821	3156	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	A randomized placebo controlled trial on the effects of simvastatin , a HMG-CoA_reductase inhibitor , on blood lipids and fibrinolytic parameters .
1627634	0	simvastatin	112,123	HMG-CoA_reductase	14,31	simvastatin	HMG-CoA reductase	MESH:D019821	3156	Chemical	Gene	expression|nmod|START_ENTITY expression|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of HMG-CoA_reductase , apoprotein-B and LDL_receptor gene expression by the hypocholesterolemic drugs simvastatin and ciprofibrate in Hep G2 , human and rat hepatocytes .
1794817	0	simvastatin	34,45	HMG-CoA_reductase	5,22	simvastatin	HMG-CoA reductase	MESH:D019821	3156	Chemical	Gene	inhibitors|dobj|START_ENTITY inhibitors|nsubj|END_ENTITY	-LSB- The HMG-CoA_reductase inhibitors simvastatin and pravastatin .
18270459	0	simvastatin	29,40	HMG-CoA_reductase	0,17	simvastatin	HMG-CoA reductase	MESH:D019821	3156	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	HMG-CoA_reductase inhibitor , simvastatin improves reverse cholesterol transport in type 2 diabetic patients with hyperlipidemia .
19150339	0	simvastatin	25,36	HMG-CoA_reductase	133,150	simvastatin	HMG-CoA reductase	MESH:D019821	15357(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY independent|nsubj|effect independent|nmod|inhibition inhibition|nmod|END_ENTITY	The protective effect of simvastatin against low dose streptozotocin induced type 1 diabetes in mice is independent of inhibition of HMG-CoA_reductase .
2047945	0	simvastatin	19,30	HMG-CoA_reductase	32,49	simvastatin	HMG-CoA reductase	MESH:D019821	3156	Chemical	Gene	trial|nmod|START_ENTITY trial|appos|inhibitor inhibitor|amod|END_ENTITY	A 6-month trial of simvastatin -LRB- HMG-CoA_reductase inhibitor -RRB- in the treatment of hypercholesterolaemia .
23846804	0	simvastatin	30,41	HMG-CoA_reductase	0,17	simvastatin	HMG-CoA reductase	MESH:D019821	3156	Chemical	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	HMG-CoA_reductase inhibitors , simvastatin and atorvastatin , downregulate ABCG1-mediated cholesterol efflux in human macrophages .
2634479	0	simvastatin	38,49	HMG-CoA_reductase	67,84	simvastatin	HMG-CoA reductase	MESH:D019821	3156	Chemical	Gene	treatment|nmod|START_ENTITY Effect|nmod|treatment Effect|appos|inhibitor inhibitor|nmod|END_ENTITY	-LSB- Effect of a long-term treatment with simvastatin , an inhibitor of HMG-CoA_reductase , in dyslipidemic patients at high risk -RSB- .
8461338	0	simvastatin	46,57	HMG-CoA_reductase	18,35	simvastatin	HMG-CoA reductase	MESH:D019821	25675(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|inhibitor inhibitor|amod|END_ENTITY	The effect of the HMG-CoA_reductase inhibitor simvastatin and of cholestyramine on hepatic apolipoprotein mRNA levels in the rat .
22985805	0	simvastatin	52,63	Hydroxymethylglutaryl-CoA_reductase	0,35	simvastatin	Hydroxymethylglutaryl-CoA reductase	MESH:D019821	3156	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Hydroxymethylglutaryl-CoA_reductase inhibition with simvastatin in acute_lung_injury to reduce pulmonary_dysfunction -LRB- HARP-2 -RRB- trial : study protocol for a randomized controlled trial .
11219190	0	simvastatin	32,43	IFN-gamma	53,62	simvastatin	IFN-gamma	MESH:D019821	3458	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	The HMG-CoA_reductase inhibitor simvastatin inhibits IFN-gamma induced MHC class II expression in human vascular endothelial cells .
17641834	0	simvastatin	10,21	IL-6	25,29	simvastatin	IL-6	MESH:D019821	16193(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|amod|END_ENTITY	Effect of simvastatin on IL-6 and adiponectin secretion and mRNA expression in 3T3-L1 adipocytes .
20065508	0	simvastatin	92,103	IL-6	0,4	simvastatin	IL-6	MESH:D019821	3569	Chemical	Gene	subjected|nmod|START_ENTITY subjected|nsubj|responses responses|amod|END_ENTITY	IL-6 and IL-8 responses of colorectal_cancer in vivo and in vitro cancer cells subjected to simvastatin .
25129462	0	simvastatin	10,21	IL17	39,43	simvastatin	IL17	MESH:D019821	301289(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effect of simvastatin on expression of IL17 , HMGB1 and TLR4 in LN kidney tissues of rats .
15899106	0	simvastatin	64,75	LDL-C	0,5	simvastatin	LDL-C	MESH:D019821	22796	Chemical	Gene	treatment|compound|START_ENTITY attainment|nmod|treatment attainment|nsubj|goal goal|amod|END_ENTITY	LDL-C goal attainment with the addition of ezetimibe to ongoing simvastatin treatment in coronary_heart_disease patients with hypercholesterolemia .
15982505	0	simvastatin	51,62	LDL-C	76,81	simvastatin	LDL-C	MESH:D019821	22796	Chemical	Gene	treatment|compound|START_ENTITY treatment|nmod|goal goal|amod|END_ENTITY	Effect of co-administering ezetimibe with on-going simvastatin treatment on LDL-C goal attainment in hypercholesterolemic patients with coronary_heart_disease .
16369229	0	simvastatin	42,53	LDL-C	0,5	simvastatin	LDL-C	MESH:D019821	22796	Chemical	Gene	coadministration|compound|START_ENTITY ezetimibe|nmod|coadministration attainment|nmod|ezetimibe attainment|amod|END_ENTITY	LDL-C goal attainment with ezetimibe plus simvastatin coadministration vs atorvastatin or simvastatin monotherapy in patients at high risk of CHD .
20203452	0	simvastatin	112,123	LDL-C	0,5	simvastatin	LDL-C	MESH:D019821	22796	Chemical	Gene	doses|nmod|START_ENTITY remain|nmod|doses patients|acl:relcl|remain attainment|nmod|patients attainment|amod|END_ENTITY	LDL-C goal attainment in patients who remain on atorvastatin or switch to equivalent or non-equivalent doses of simvastatin : a retrospective matched cohort study in clinical practice .
21291710	0	simvastatin	12,23	LDL-C	49,54	simvastatin	LDL-C	MESH:D019821	22796	Chemical	Gene	therapy|compound|START_ENTITY Efficacy|nmod|therapy Efficacy|nmod|levels levels|compound|END_ENTITY	Efficacy of simvastatin therapy in attainment of LDL-C and TG goal levels in patients with type 2 diabetic_dyslipidemia .
8457250	0	simvastatin	82,93	LDL-receptor	39,51	simvastatin	LDL-receptor	MESH:D019821	3949	Chemical	Gene	response|acl|START_ENTITY locus|nmod|response locus|nsubj|Influence Influence|nmod|mutations mutations|nmod|gene gene|amod|END_ENTITY	Influence of specific mutations at the LDL-receptor gene locus on the response to simvastatin therapy in Afrikaner patients with heterozygous familial_hypercholesterolaemia .
8831932	0	simvastatin	57,68	LDL-receptor	80,92	simvastatin	LDL-receptor	MESH:D019821	3949	Chemical	Gene	therapy|compound|START_ENTITY therapy|nmod|END_ENTITY	Familial_defective_apolipoprotein_B-100 -LRB- FDB -RRB- : effect of simvastatin therapy on LDL-receptor binding .
11181283	0	simvastatin	88,99	LDL_receptor	51,63	simvastatin	LDL receptor	MESH:D019821	3949	Chemical	Gene	response|acl|START_ENTITY gene|nmod|response gene|compound|END_ENTITY	-LSB- Influence of FH Valencia 1 and 2 mutations of the LDL_receptor gene on the response to simvastatin in subjects with molecularly defined heterozygous familial_hypercholesterolemia in Spain -RSB- .
17980884	0	simvastatin	28,39	LDL_receptor	43,55	simvastatin	LDL receptor	MESH:D019821	3949	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effects of ezetimibe and/or simvastatin on LDL_receptor protein expression and on LDL_receptor and HMG-CoA_reductase gene expression : a randomized trial in healthy men .
9633944	0	simvastatin	101,112	LDL_receptor	24,36	simvastatin	LDL receptor	MESH:D019821	3949	Chemical	Gene	plasma|nmod|START_ENTITY plasma|nsubj|Association Association|nmod|mutations mutations|compound|END_ENTITY	Association of specific LDL_receptor gene mutations with differential plasma lipoprotein response to simvastatin in young French Canadians with heterozygous familial_hypercholesterolemia .
14625131	0	simvastatin	116,127	Leptin	0,6	simvastatin	Leptin	MESH:D019821	3952	Chemical	Gene	lowering|nmod|START_ENTITY associated|xcomp|lowering associated|nsubjpass|polymorphism polymorphism|compound|END_ENTITY	Leptin receptor polymorphism is associated with serum lipid levels and impairment of cholesterol lowering effect by simvastatin in Japanese men .
16480888	0	simvastatin	78,89	NF-kB	14,19	simvastatin	NF-kB	MESH:D019821	81736(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY abolished|nmod|treatment abolished|nsubjpass|Activation Activation|nmod|END_ENTITY	Activation of NF-kB and ERK1/2 after permanent focal ischemia is abolished by simvastatin treatment .
21076490	0	simvastatin	10,21	NF-kB	84,89	simvastatin	NF-kB	MESH:D019821	81736(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|role role|nmod|END_ENTITY	Effect of simvastatin on collagen I deposition in non-infarcted myocardium : role of NF-kB and osteopontin .
15497697	0	simvastatin	42,53	P-glycoprotein	22,36	simvastatin	P-glycoprotein	MESH:D019821	5243	Chemical	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of human P-glycoprotein with simvastatin , simvastatin_acid , and atorvastatin .
22358108	0	simvastatin	11,22	P-glycoprotein	173,187	simvastatin	P-glycoprotein	MESH:D019821	287115(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|dep|role role|nmod|END_ENTITY	Effects of simvastatin on the pharmacokinetics of diltiazem and its main metabolite , desacetyldiltiazem , after oral and intravenous administration in rats : possible role of P-glycoprotein and CYP3A4 inhibition by simvastatin .
22358108	0	simvastatin	213,224	P-glycoprotein	173,187	simvastatin	P-glycoprotein	MESH:D019821	287115(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY role|acl|inhibition role|nmod|END_ENTITY	Effects of simvastatin on the pharmacokinetics of diltiazem and its main metabolite , desacetyldiltiazem , after oral and intravenous administration in rats : possible role of P-glycoprotein and CYP3A4 inhibition by simvastatin .
22659627	0	simvastatin	50,61	PKA	163,166	simvastatin	PKA	MESH:D019821	397652(Tax:9823)	Chemical	Gene	START_ENTITY|nmod|pathway pathway|compound|END_ENTITY	Phosphorylation of endothelial NOS contributes to simvastatin protection against myocardial no-reflow and infarction in reperfused swine hearts : partially via the PKA signaling pathway .
22537532	0	simvastatin	28,39	PPAR-a	103,109	simvastatin	PPAR-a	MESH:D019821	19013(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|involvement involvement|nmod|END_ENTITY	Anti-inflammatory effect of simvastatin in an experimental model of spinal_cord_trauma : involvement of PPAR-a .
21323892	0	simvastatin	47,58	PPARa	0,5	simvastatin	PPARa	MESH:D019821	19013(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY mediates|dobj|effect mediates|nsubj|END_ENTITY	PPARa mediates the anti-inflammatory effect of simvastatin in an experimental model of zymosan-induced multiple_organ_failure .
16397146	7	simvastatin	1269,1280	PPARalpha	1328,1337	simvastatin	PPARalpha	MESH:D019821	5465	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	A constitutive active form of PKCalpha inhibited nuclear factor kappaB transrepression by PPARalpha whereas simvastatin enhanced transrepression activity of wild-type PPARalpha , but not of PPARalpha mutated in its PKC phosphorylation sites .
21177169	0	simvastatin	12,23	SOD	34,37	simvastatin	SOD	MESH:D019821	6647	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of simvastatin on plasma SOD , MDA and 8-iso-PGF2a in patients with stable_angina -RSB- .
20128155	0	simvastatin	52,63	TLR4	73,77	simvastatin	TLR4	MESH:D019821	29260(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|pathway pathway|compound|END_ENTITY	In rats with myocardial_infarction , interference by simvastatin with the TLR4 signal pathway attenuates ventricular remodelling .
10365819	0	simvastatin	10,21	alpha-fetoprotein	87,104	simvastatin	alpha-fetoprotein	MESH:D019821	174	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of simvastatin , a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor , on alpha-fetoprotein gene expression through interaction with the ras-mediated pathway .
15785028	0	simvastatin	14,25	amyloid_precursor_protein	43,68	simvastatin	amyloid precursor protein	MESH:D019821	351	Chemical	Gene	treatment|compound|START_ENTITY effect|nmod|treatment effect|nmod|END_ENTITY	The effect of simvastatin treatment on the amyloid_precursor_protein and brain cholesterol metabolism in patients with Alzheimer 's _ disease .
25492829	0	simvastatin	14,25	angiotensin_II	127,141	simvastatin	angiotensin II	MESH:D019821	24179(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of simvastatin and pravastatin on arterial blood pressure , baroreflex , vasoconstrictor , and hypertensive effects of angiotensin_II in Sprague-Dawley_rats .
8427854	0	simvastatin	11,22	apoB	26,30	simvastatin	apoB	MESH:D019821	338	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|metabolism metabolism|amod|END_ENTITY	Effects of simvastatin on apoB metabolism and LDL subfraction distribution .
20461472	0	simvastatin	13,24	apoB-100	28,36	simvastatin	apoB-100	MESH:D019821	338	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|secretion secretion|amod|END_ENTITY	Influence of simvastatin on apoB-100 secretion in non-obese subjects with mild hypercholesterolemia .
12508427	0	simvastatin	11,22	bone_morphogenetic_protein-2	26,54	simvastatin	bone morphogenetic protein-2	MESH:D019821	650	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effect of simvastatin on bone_morphogenetic_protein-2 expression and alkaline phosphatase activity of bone marrow stromal cell -RSB- .
18380969	0	simvastatin	11,22	bone_morphogenetic_protein-2	26,54	simvastatin	bone morphogenetic protein-2	MESH:D019821	29373(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	-LSB- Effect of simvastatin on bone_morphogenetic_protein-2 expression in the periodontal tissue after rat tooth movement -RSB- .
22842798	0	simvastatin	15,26	caspase-3	42,51	simvastatin	caspase-3	MESH:D019821	25402(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|amod|END_ENTITY	The effects of simvastatin on hippocampal caspase-3 and Bcl-2 expression following kainate-induced seizures in rats .
16720415	0	simvastatin	83,94	cholesteryl_ester_transfer_protein	36,70	simvastatin	cholesteryl ester transfer protein	MESH:D019821	100327267(Tax:9986)	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Assessing lipid lowering and plasma cholesteryl_ester_transfer_protein activity of simvastatin following administration to rabbits fed a high fat/cholesterol diet .
22932337	0	simvastatin	12,23	connective_tissue_growth_factor	41,72	simvastatin	connective tissue growth factor	MESH:D019821	64032(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of simvastatin on expression of connective_tissue_growth_factor in vitreous and retina of diabetic rats -RSB- .
18390205	0	simvastatin	11,22	endothelin-1	26,38	simvastatin	endothelin-1	MESH:D019821	1906	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effect of simvastatin on endothelin-1 expression in endothelial cell cultured hypoxically -RSB- .
23672611	0	simvastatin	11,22	endothelin-1	78,90	simvastatin	endothelin-1	MESH:D019821	24323(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY vascular|nsubj|Effects vascular|nmod|degree degree|amod|END_ENTITY	Effects of simvastatin on the portal-systemic collateral vascular response to endothelin-1 and shunting degree in portal hypertensive rats .
10498134	0	simvastatin	10,21	familial_hypercholesterolemia	117,146	simvastatin	familial hypercholesterolemia	MESH:D019821	3949	Chemical	Gene	treatment|compound|START_ENTITY Effect|nmod|treatment present|nsubj|Effect present|nmod|patients patients|nmod|END_ENTITY	Effect of simvastatin treatment on the electronegative low-density lipoprotein present in patients with heterozygous familial_hypercholesterolemia .
11009276	0	simvastatin	68,79	familial_hypercholesterolemia	103,132	simvastatin	familial hypercholesterolemia	MESH:D019821	3949	Chemical	Gene	cholesterol|nmod|START_ENTITY cholesterol|nmod|END_ENTITY	High-density lipoprotein cholesterol and triglyceride response with simvastatin versus atorvastatin in familial_hypercholesterolemia .
11472751	0	simvastatin	80,91	familial_hypercholesterolemia	36,65	simvastatin	familial hypercholesterolemia	MESH:D019821	3949	Chemical	Gene	therapy|compound|START_ENTITY effect|nmod|therapy C-reactive_protein|dep|effect C-reactive_protein|nmod|patients patients|nmod|END_ENTITY	C-reactive_protein in patients with familial_hypercholesterolemia : no effect of simvastatin therapy .
12204807	0	simvastatin	65,76	familial_hypercholesterolemia	94,123	simvastatin	familial hypercholesterolemia	MESH:D019821	3949	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	Baseline lipid values partly determine the response to high-dose simvastatin in patients with familial_hypercholesterolemia .
12912721	0	simvastatin	113,124	familial_hypercholesterolemia	67,96	simvastatin	familial hypercholesterolemia	MESH:D019821	3949	Chemical	Gene	treatment|nmod|START_ENTITY Regression|dep|treatment Regression|nmod|intima-media_thickness intima-media_thickness|nmod|END_ENTITY	Regression of carotid and femoral artery intima-media_thickness in familial_hypercholesterolemia : treatment with simvastatin .
16196425	0	simvastatin	96,107	familial_hypercholesterolemia	54,83	simvastatin	familial hypercholesterolemia	MESH:D019821	3949	Chemical	Gene	effects|nmod|START_ENTITY kinetics|dep|effects kinetics|nmod|cholesterol cholesterol|nmod|END_ENTITY	Plasma kinetics of free and esterified cholesterol in familial_hypercholesterolemia : effects of simvastatin .
2390138	0	simvastatin	51,62	familial_hypercholesterolemia	103,132	simvastatin	familial hypercholesterolemia	MESH:D019821	3949	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	Influence of apo_E polymorphism on the response to simvastatin treatment in patients with heterozygous familial_hypercholesterolemia .
9633944	0	simvastatin	101,112	familial_hypercholesterolemia	157,186	simvastatin	familial hypercholesterolemia	MESH:D019821	3949	Chemical	Gene	plasma|nmod|START_ENTITY plasma|nmod|END_ENTITY	Association of specific LDL_receptor gene mutations with differential plasma lipoprotein response to simvastatin in young French Canadians with heterozygous familial_hypercholesterolemia .
24438607	0	simvastatin	10,21	farnesoid_X_receptor	43,63	simvastatin	farnesoid X receptor	MESH:D019821	60351(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of simvastatin on the expression of farnesoid_X_receptor in diabetic animal models of altered glucose homeostasis .
10910028	0	simvastatin	33,44	fibrinogen	48,58	simvastatin	fibrinogen	MESH:D019821	2244	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|parameters parameters|compound|END_ENTITY	Influence of atorvastatin versus simvastatin on fibrinogen and other hemorheological parameters in patients with severe hypercholesterolemia treated with regular low-density lipoprotein immunoadsorption apheresis .
15662091	0	simvastatin	10,21	fibrinogen	48,58	simvastatin	fibrinogen	MESH:D019821	2244	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|compound|END_ENTITY	Effect of simvastatin and fluvastatin on plasma fibrinogen levels in patients with primary_hypercholesterolemia .
18337668	0	simvastatin	37,48	heme_oxygenase-1	100,116	simvastatin	heme oxygenase-1	MESH:D019821	24451(Tax:10116)	Chemical	Gene	preconditioning|nmod|START_ENTITY protects|nsubj|preconditioning protects|nmod|induction induction|amod|END_ENTITY	Pharmacological preconditioning with simvastatin protects liver from ischemia-reperfusion injury by heme_oxygenase-1 induction .
22918643	0	simvastatin	11,22	heme_oxygenase-1	44,60	simvastatin	heme oxygenase-1	MESH:D019821	3162	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of simvastatin on the expression of heme_oxygenase-1 in human RPE cells .
25093998	0	simvastatin	21,32	heme_oxygenase-1	76,92	simvastatin	heme oxygenase-1	MESH:D019821	3162	Chemical	Gene	Effects|amod|START_ENTITY Effects|acl|_ _|xcomp|lipoic_acid lipoic_acid|advcl|END_ENTITY	Effects of aspirin _ simvastatin and aspirin , simvastatin , _ lipoic_acid on heme_oxygenase-1 in healthy human subjects .
25093998	0	simvastatin	46,57	heme_oxygenase-1	76,92	simvastatin	heme oxygenase-1	MESH:D019821	3162	Chemical	Gene	Effects|acl|START_ENTITY Effects|acl|_ _|xcomp|lipoic_acid lipoic_acid|advcl|END_ENTITY	Effects of aspirin _ simvastatin and aspirin , simvastatin , _ lipoic_acid on heme_oxygenase-1 in healthy human subjects .
26000813	0	simvastatin	11,22	inducible_nitric_oxide_synthase	44,75	simvastatin	inducible nitric oxide synthase	MESH:D019821	24599(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of simvastatin on the expression of inducible_nitric_oxide_synthase and brain-derived_neurotrophic_factor in a lipopolysaccharide-induced rat model of Parkinson_disease .
19640331	0	simvastatin	10,21	interleukin-6	32,45	simvastatin	interleukin-6	MESH:D019821	3569	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of simvastatin on plasma interleukin-6 in patients with unstable_angina .
23013513	0	simvastatin	11,22	interleukin-6	40,53	simvastatin	interleukin-6	MESH:D019821	3569	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|C-reactive_protein C-reactive_protein|amod|END_ENTITY	Effects of simvastatin and ezetimibe on interleukin-6 and high-sensitivity C-reactive_protein .
18854995	0	simvastatin	83,94	leptin_receptor	31,46	simvastatin	leptin receptor	MESH:D019821	3953	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	The 223A > G polymorphism of the leptin_receptor gene and lipid-lowering efficacy of simvastatin in Chinese patients with coronary_heart_disease .
17350631	0	simvastatin	159,170	lipoprotein-associated_phospholipase_A2	104,143	simvastatin	lipoprotein-associated phospholipase A2	MESH:D019821	7941	Chemical	Gene	treatment|compound|START_ENTITY END_ENTITY|nmod|treatment	Lysophosphatidylcholine contents in plasma LDL in patients with type_2_diabetes_mellitus : relation with lipoprotein-associated_phospholipase_A2 and effects of simvastatin treatment .
21863259	0	simvastatin	121,132	matrix_metalloproteinase-3	151,177	simvastatin	matrix metalloproteinase-3	MESH:D019821	171045(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Mechanically induced experimental knee osteoarthritis benefits from anti-inflammatory and immunomodulatory properties of simvastatin via inhibition of matrix_metalloproteinase-3 .
16741180	0	simvastatin	80,91	matrix_metalloproteinase-9	50,76	simvastatin	matrix metalloproteinase-9	MESH:D019821	4318	Chemical	Gene	Reduction|nmod|START_ENTITY Reduction|nmod|END_ENTITY	Reduction of tissue_plasminogen_activator-induced matrix_metalloproteinase-9 by simvastatin in astrocytes .
12756509	0	simvastatin	25,36	monocyte_chemoattractant_protein-1	65,99	simvastatin	monocyte chemoattractant protein-1	MESH:D019821	6347	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|amod|END_ENTITY	Effects of atorvastatin , simvastatin , and fenofibrate therapy on monocyte_chemoattractant_protein-1 secretion in patients with hyperlipidemia .
16781696	0	simvastatin	138,149	monocyte_chemoattractant_protein-1	18,52	simvastatin	monocyte chemoattractant protein-1	MESH:D019821	6347	Chemical	Gene	treatment|compound|START_ENTITY expression|nmod|treatment expression|acl|END_ENTITY	The expression of monocyte_chemoattractant_protein-1 and C-C_chemokine_receptor_2 in post-kidney transplant patients and the influence of simvastatin treatment .
18413153	0	simvastatin	14,25	monocyte_chemoattractant_protein-1	39,73	simvastatin	monocyte chemoattractant protein-1	MESH:D019821	24770(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of simvastatin on the serum monocyte_chemoattractant_protein-1 and intracellular_adhesion_molecule-1 levels in diabetic rats .
11009568	0	simvastatin	102,113	preproendothelin-1	64,82	simvastatin	preproendothelin-1	MESH:D019821	281137(Tax:9913)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Involvement of Rho GTPases in the transcriptional inhibition of preproendothelin-1 gene expression by simvastatin in vascular endothelial cells .
24819315	0	simvastatin	10,21	visfatin	42,50	simvastatin	visfatin	MESH:D019821	10135	Chemical	Gene	treatment|compound|START_ENTITY Effect|nmod|treatment Effect|nmod|levels levels|compound|END_ENTITY	Effect of simvastatin treatment on plasma visfatin levels in obese women .
18589789	0	sinapine	23,31	acetylcholinesterase	47,67	sinapine	acetylcholinesterase	MESH:C005685	83817(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	-LSB- Inhibitory effects of sinapine on activity of acetylcholinesterase in cerebral homogenate and blood serum of rats -RSB- .
22833666	0	sinapoylglucose	60,75	Nitrate_reductase	0,17	sinapoylglucose	Nitrate reductase	MESH:C103373	844112(Tax:3702)	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Nitrate_reductase - and nitric_oxide-dependent activation of sinapoylglucose : malate_sinapoyltransferase in leaves of Arabidopsis_thaliana .
7717068	0	sincalide	63,72	c-fos	8,13	sincalide	c-fos	MESH:D012844	314322(Tax:10116)	Chemical	Gene	induction|nmod|START_ENTITY induction|nsubj|END_ENTITY	Protein c-fos induction in rat brain and spinal dorsal horn by sincalide and opioids in vitro .
20347768	0	sinefungin	66,76	rpoB	80,84	sinefungin	rpoB	MESH:C006235	1100095(Tax:100226)	Chemical	Gene	START_ENTITY|nmod|mutation mutation|compound|END_ENTITY	Production improvement of antifungal , antitrypanosomal nucleoside sinefungin by rpoB mutation and optimization of resting cell system of Streptomyces incarnatus NRRL 8089 .
16759518	0	sinomenine	25,35	COX-2	39,44	sinomenine	COX-2	MESH:C009271	26198(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	-LSB- Effects of the alkaloid sinomenine on COX-2 activity and acute rejection in heart allografts : an experiment with rats -RSB- .
15575215	0	sinomenine	22,32	cyclooxygenase-2	50,66	sinomenine	cyclooxygenase-2	MESH:C009271	29527(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Inhibitory effect of sinomenine on expression of cyclooxygenase-2 in lipopolysaccharide-induced PC-12 cells -RSB- .
1847706	0	sinorphan	10,19	atrial_natriuretic_factor	59,84	sinorphan	atrial natriuretic factor	MESH:C049331	4878	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of sinorphan , an enkephalinase inhibitor , on plasma atrial_natriuretic_factor and sodium urinary excretion in cirrhotic patients with ascites .
1847706	0	sinorphan	10,19	enkephalinase	24,37	sinorphan	enkephalinase	MESH:C049331	4311	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effect of sinorphan , an enkephalinase inhibitor , on plasma atrial_natriuretic_factor and sodium urinary excretion in cirrhotic patients with ascites .
11172753	0	sipatrigine	26,37	TREK-1	110,116	sipatrigine	TREK-1	MESH:C081980	3776	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|channels channels|amod|END_ENTITY	The neuroprotective agent sipatrigine -LRB- BW619C89 -RRB- potently inhibits the human tandem pore-domain K -LRB- + -RRB- channels TREK-1 and TRAAK .
23437092	0	sirolimus	95,104	VEGF-D	24,30	sirolimus	VEGF-D	MESH:D020123	2277	Chemical	Gene	treatment|compound|START_ENTITY END_ENTITY|nmod|treatment	Similar trends in serum VEGF-D levels and kidney_angiomyolipoma responses with longer duration sirolimus treatment in adults with tuberous_sclerosis .
21393611	0	sirolimus	9,18	angiotensin-converting_enzyme	33,62	sirolimus	angiotensin-converting enzyme	MESH:D020123	1636	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|amod|END_ENTITY	Low-dose sirolimus combined with angiotensin-converting_enzyme inhibitor and statin stabilizes renal function and reduces glomerular proliferation in poor prognosis IgA nephropathy .
11602850	0	sirolimus	10,19	apoB100	41,48	sirolimus	apoB100	MESH:D020123	338	Chemical	Gene	START_ENTITY|nmod|metabolism metabolism|nmod|END_ENTITY	Effect of sirolimus on the metabolism of apoB100 - containing lipoproteins in renal transplant patients .
25843527	0	sirolimus	87,96	calcineurin_inhibitor	113,134	sirolimus	calcineurin inhibitor	MESH:D020123	23523	Chemical	Gene	START_ENTITY|acl|combined combined|nmod|END_ENTITY	De novo cancer avoidance after renal transplantation : A case-control study on low-dose sirolimus combined with a calcineurin_inhibitor .
17353769	0	sirolimus	31,40	insulin	44,51	sirolimus	insulin	MESH:D020123	3630	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	In vivo and in vitro effect of sirolimus on insulin secretion .
16896936	0	sirolimus	33,42	mTOR	18,22	sirolimus	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|impact impact|nmod|inhibitor inhibitor|compound|END_ENTITY	The impact of the mTOR inhibitor sirolimus on the proliferation and function of pancreatic islets and ductal cells .
18307022	0	sirolimus	30,39	mTOR	15,19	sirolimus	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|inhibitor inhibitor|compound|END_ENTITY	Effects of the mTOR inhibitor sirolimus in patients with hepatocellular and cholangiocellular_cancer .
19389529	0	sirolimus	61,70	mTOR	46,50	sirolimus	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|response response|nmod|treatment treatment|nmod|inhibitor inhibitor|compound|END_ENTITY	Significant response after treatment with the mTOR inhibitor sirolimus in combination with carboplatin and paclitaxel in metastatic_melanoma patients .
20048174	0	sirolimus	42,51	mTOR	21,25	sirolimus	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Clinical activity of mTOR inhibition with sirolimus in malignant perivascular epithelioid cell tumors : targeting the pathogenic activation of mTORC1 in tumors .
20630348	5	sirolimus	797,806	mTOR	696,700	sirolimus	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	e.g.|dep|START_ENTITY inhibitors|appos|e.g. trials|nmod|inhibitors initiation|nmod|trials basis|nmod|initiation basis|nsubj|involvement involvement|nmod|END_ENTITY	The involvement of mTOR in LAM pathogenesis is the basis for initiation of therapeutic trials of mTOR inhibitors -LRB- e.g. , sirolimus -RRB- .
20970607	0	sirolimus	98,107	mTOR	63,67	sirolimus	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	everolimus|nmod|START_ENTITY analysis|dep|everolimus analysis|nmod|events events|acl|requiring requiring|dobj|suspension suspension|nmod|inhibitors inhibitors|compound|END_ENTITY	Comparative analysis of adverse events requiring suspension of mTOR inhibitors : everolimus versus sirolimus .
21168455	0	sirolimus	48,57	mTOR	32,36	sirolimus	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	inhibitors|dobj|START_ENTITY inhibitors|nsubj|activity activity|nmod|END_ENTITY	Potent antifibrotic activity of mTOR inhibitors sirolimus and everolimus but not of cyclosporine_A and tacrolimus in experimental liver_fibrosis .
22167413	0	sirolimus	146,155	mTOR	131,135	sirolimus	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	Single-cell pharmacodynamic monitoring of S6 ribosomal protein phosphorylation in AML blasts during a clinical trial combining the mTOR inhibitor sirolimus and intensive chemotherapy .
23079231	0	sirolimus	60,69	mTOR	45,49	sirolimus	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|effects effects|nmod|END_ENTITY	Synergistic immunosuppressive effects of the mTOR inhibitor sirolimus and the phytochemical curcumin .
24882386	6	sirolimus	977,986	mTOR	959,963	sirolimus	IL-8	MESH:D020123	3576	Chemical	Gene	had|nsubj|START_ENTITY inhibitors|ccomp|had inhibitors|nsubj|mammalian_target_of_rapamycin mammalian_target_of_rapamycin|appos|END_ENTITY	Under basal conditions , mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitors -LRB- sirolimus and everolimus -RRB- had the most potent anti-inflammatory effect , decreasing both IL-8 release -LRB- -80 % -RRB- and vascular_endothelial_growth_factor -LRB- VEGF -RRB- release -LRB- -65 % -RRB- and preserving the release of the anti-inflammatory cytokine interleukin-1_receptor_antagonist -LRB- IL-1RA -RRB- .
25003665	0	sirolimus	72,81	mTOR	57,61	sirolimus	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|study study|nmod|inhibitor inhibitor|compound|END_ENTITY	Phase I study and preclinical efficacy evaluation of the mTOR inhibitor sirolimus plus gemcitabine in patients with advanced solid tumours .
25531195	0	sirolimus	45,54	mTOR	28,32	sirolimus	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	associated|dep|START_ENTITY associated|nmod|inhibitors inhibitors|compound|END_ENTITY	Lung_injury associated with mTOR inhibitors -LRB- sirolimus and everolimus -RRB- .
26722609	0	sirolimus	19,28	mTOR	4,8	sirolimus	mTOR	MESH:D020123	21977(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|inhibitor inhibitor|compound|END_ENTITY	The mTOR inhibitor sirolimus suppresses renal , hepatic , and cardiac tissue cellular respiration -LSB- Retraction -RSB- .
20048174	0	sirolimus	42,51	mTORC1	142,148	sirolimus	mTORC1	MESH:D020123	382056(Tax:10090)	Chemical	Gene	inhibition|nmod|START_ENTITY activity|nmod|inhibition epithelioid|nsubj|activity epithelioid|parataxis|targeting targeting|dobj|activation activation|nmod|END_ENTITY	Clinical activity of mTOR inhibition with sirolimus in malignant perivascular epithelioid cell tumors : targeting the pathogenic activation of mTORC1 in tumors .
21076853	0	sirolimus	58,67	mTORC1	0,6	sirolimus	mTORC1	MESH:D020123	382056(Tax:10090)	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	mTORC1 activation in childhood_ependymoma and response to sirolimus .
19843663	0	sirolimus	63,72	mammalian_target_of_rapamycin	23,52	sirolimus	mammalian target of rapamycin	MESH:D020123	2475	Chemical	Gene	START_ENTITY|nsubj|study study|nmod|inhibitor inhibitor|compound|END_ENTITY	A phase I study of the mammalian_target_of_rapamycin inhibitor sirolimus and MEC chemotherapy in relapsed and refractory_acute_myelogenous_leukemia .
25649370	0	sirolimus	62,71	mammalian_target_of_rapamycin	22,51	sirolimus	mammalian target of rapamycin	MESH:D020123	2475	Chemical	Gene	START_ENTITY|nsubj|study study|nmod|inhibitor inhibitor|compound|END_ENTITY	Phase 1b study of the mammalian_target_of_rapamycin inhibitor sirolimus in combination with nanoparticle albumin-bound paclitaxel in patients with advanced solid tumors .
23666574	0	sirolimus	31,40	neurofibromatosis_type_1	68,92	sirolimus	neurofibromatosis type 1	MESH:D020123	4763	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY pharmacokinetics|nmod|END_ENTITY	Population pharmacokinetics of sirolimus in pediatric patients with neurofibromatosis_type_1 .
18853950	0	sirolimus	14,23	prostate-specific_antigen	27,52	sirolimus	prostate-specific antigen	MESH:D020123	354	Chemical	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	The effect of sirolimus on prostate-specific_antigen -LRB- PSA -RRB- levels in male_renal_transplant_recipients_without_prostate_cancer .
24482345	0	sirtinol	20,28	SIRT1	0,5	sirtinol	SIRT1	MESH:C439060	309757(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nummod|END_ENTITY	SIRT1 inhibition by sirtinol aggravates brain_edema after experimental subarachnoid_hemorrhage .
17433672	0	sitagliptin	158,169	DPP-4	76,81	sitagliptin	DPP-4	MESH:C496398	1803	Chemical	Gene	modeling|nmod|START_ENTITY application|nmod|modeling inhibitor|nmod|application inhibitor|nsubj|design design|nmod|END_ENTITY	Rational design of a novel , potent , and orally bioavailable cyclohexylamine DPP-4 inhibitor by application of molecular modeling and X-ray crystallography of sitagliptin .
17939170	0	sitagliptin	90,101	DPP-4	105,110	sitagliptin	DPP-4	MESH:C496398	1803	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Sensitive liquid chromatography tandem mass spectrometry method for the quantification of sitagliptin , a DPP-4 inhibitor , in human plasma using liquid-liquid extraction .
19783710	0	sitagliptin	18,29	DPP-4	43,48	sitagliptin	DPP-4	MESH:C496398	1803	Chemical	Gene	doses|nmod|START_ENTITY doses|appos|inhibitor inhibitor|compound|END_ENTITY	Multiple doses of sitagliptin , a selective DPP-4 inhibitor , do not meaningfully alter pharmacokinetics and pharmacodynamics of warfarin .
20039889	0	sitagliptin	36,47	DPP-4	14,19	sitagliptin	DPP-4	MESH:C496398	1803	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|effect effect|nmod|END_ENTITY	The effect of DPP-4 inhibition with sitagliptin on incretin secretion and on fasting and postprandial_glucose_turnover in subjects with impaired fasting glucose .
20075143	0	sitagliptin	20,31	DPP-4	0,5	sitagliptin	DPP-4	MESH:C496398	1803	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	DPP-4 inhibition by sitagliptin improves the myocardial response to dobutamine stress and mitigates stunning in a pilot study of patients with coronary_artery_disease .
20380653	0	sitagliptin	49,60	DPP-4	32,37	sitagliptin	DPP-4	MESH:C496398	1803	Chemical	Gene	treatment|appos|START_ENTITY treatment|nmod|inhibitor inhibitor|compound|END_ENTITY	Twelve weeks treatment with the DPP-4 inhibitor , sitagliptin , prevents degradation of peptide_YY and improves glucose and non-glucose induced insulin secretion in patients with type_2_diabetes_mellitus .
20519186	0	sitagliptin	70,81	DPP-4	52,57	sitagliptin	DPP-4	MESH:C496398	1803	Chemical	Gene	inhibitors|appos|START_ENTITY inhibitors|compound|END_ENTITY	-LSB- A new therapeutic possibility for type 2 diabetes : DPP-4 inhibitors -LRB- sitagliptin -RRB- -RSB- .
21437074	0	sitagliptin	53,64	DPP-4	7,12	sitagliptin	DPP-4	MESH:C496398	1803	Chemical	Gene	focus|nmod|START_ENTITY Use|dep|focus Use|nmod|inhibitors inhibitors|compound|END_ENTITY	Use of DPP-4 inhibitors in type 2 diabetes : focus on sitagliptin .
21673098	0	sitagliptin	79,90	DPP-4	63,68	sitagliptin	DPP-4	MESH:C496398	13482(Tax:10090)	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|END_ENTITY	Physiological and pharmacological mechanisms through which the DPP-4 inhibitor sitagliptin regulates glycemia in mice .
22153807	0	sitagliptin	84,95	DPP-4	52,57	sitagliptin	DPP-4	MESH:C496398	1803	Chemical	Gene	predicts|nmod|START_ENTITY predicts|nsubj|level level|nmod|CD26/dipeptidyl CD26/dipeptidyl|appos|END_ENTITY	Serum level of soluble CD26/dipeptidyl _ peptidase-4 -LRB- DPP-4 -RRB- predicts the response to sitagliptin , a DPP-4 inhibitor , in patients with type 2 diabetes controlled inadequately by metformin and/or sulfonylurea .
22153807	0	sitagliptin	84,95	DPP-4	99,104	sitagliptin	DPP-4	MESH:C496398	1803	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Serum level of soluble CD26/dipeptidyl _ peptidase-4 -LRB- DPP-4 -RRB- predicts the response to sitagliptin , a DPP-4 inhibitor , in patients with type 2 diabetes controlled inadequately by metformin and/or sulfonylurea .
23331498	0	sitagliptin	47,58	DPP-4	31,36	sitagliptin	DPP-4	MESH:C496398	1803	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|inhibitor inhibitor|compound|END_ENTITY	Glucose-lowering effect of the DPP-4 inhibitor sitagliptin after glucose and non-glucose macronutrient ingestion in non-diabetic subjects .
23468467	0	sitagliptin	137,148	DPP-4	119,124	sitagliptin	DPP-4	MESH:C496398	1803	Chemical	Gene	inhibitors|appos|START_ENTITY inhibitors|compound|END_ENTITY	A novel model-based meta-analysis to indirectly estimate the comparative efficacy of two medications : an example using DPP-4 inhibitors , sitagliptin and linagliptin , in treatment of type_2_diabetes_mellitus .
24772702	0	sitagliptin	19,30	DPP-4	34,39	sitagliptin	DPP-4	MESH:C496398	1803	Chemical	Gene	review|nmod|START_ENTITY review|dep|inhibitor inhibitor|compound|END_ENTITY	Clinical review of sitagliptin : a DPP-4 inhibitor .
18686043	0	sitagliptin	66,77	DPP4	87,91	sitagliptin	DPP4	MESH:C496398	1803	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Accelerating drug development using biomarkers : a case study with sitagliptin , a novel DPP4 inhibitor for type 2 diabetes .
19259628	0	sitagliptin	22,33	DPP4	0,4	sitagliptin	DPP4	MESH:C496398	1803	Chemical	Gene	monotherapy|compound|START_ENTITY inhibitors|nmod|monotherapy inhibitors|nummod|END_ENTITY	DPP4 inhibitors : from sitagliptin monotherapy to the new alogliptin-pioglitazone combination therapy .
19602719	0	sitagliptin	45,56	DPP4	60,64	sitagliptin	DPP4	MESH:C496398	1803	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	A thorough QTc study to assess the effect of sitagliptin , a DPP4 inhibitor , on ventricular repolarization in healthy subjects .
26873580	0	sitagliptin	70,81	DPP4	120,124	sitagliptin	DPP4	MESH:C496398	1803	Chemical	Gene	quantitation|nmod|START_ENTITY methods|nmod|quantitation review|nmod|methods review|appos|inhibitor inhibitor|appos|END_ENTITY	A concise review of the bioanalytical methods for the quantitation of sitagliptin , an important dipeptidyl_peptidase-4 -LRB- DPP4 -RRB- inhibitor , utilized for the pharmacokinetic characterization of the drug .
17392725	0	sitagliptin	81,92	Dipeptidyl_peptidase-4	0,22	sitagliptin	Dipeptidyl peptidase-4	MESH:C496398	1803	Chemical	Gene	focus|nmod|START_ENTITY inhibitors|dep|focus inhibitors|amod|END_ENTITY	Dipeptidyl_peptidase-4 inhibitors for the treatment of type 2 diabetes : focus on sitagliptin .
23386232	0	sitagliptin	34,45	Dipeptidyl_peptidase-4	0,22	sitagliptin	Dipeptidyl peptidase-4	MESH:C496398	1803	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Dipeptidyl_peptidase-4 inhibitor , sitagliptin , improves endothelial_dysfunction in association with its anti-inflammatory effects in patients with coronary_artery_disease and uncontrolled diabetes .
17371200	0	sitagliptin	39,50	Dipeptidyl_peptidase_4	0,22	sitagliptin	Dipeptidyl peptidase 4	MESH:C496398	1803	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Dipeptidyl_peptidase_4 inhibition with sitagliptin : a new therapy for type 2 diabetes .
26524980	0	sitagliptin	87,98	Dipeptidyl_peptidase_4	1,23	sitagliptin	Dipeptidyl peptidase 4	MESH:C496398	1803	Chemical	Gene	-RSB-|compound|START_ENTITY case|nmod|-RSB- inhibitors|dep|case inhibitors|amod|END_ENTITY	-LSB- Dipeptidyl_peptidase_4 inhibitors and the risk of cardiovascular_disease : The case of sitagliptin -RSB- .
21898126	0	sitagliptin	160,171	GLP-1	88,93	sitagliptin	GLP-1	MESH:C496398	2641	Chemical	Gene	treated|nmod|START_ENTITY diabetes|acl|treated patients|nmod|diabetes lunch|nmod|patients increased|nmod|lunch increased|iobj|plasma plasma|appos|END_ENTITY	Miglitol administered before breakfast increased plasma active glucagon-like_peptide-1 -LRB- GLP-1 -RRB- levels after lunch in patients with type 2 diabetes treated with sitagliptin .
22851600	0	sitagliptin	58,69	GLP-1	83,88	sitagliptin	GLP-1	MESH:C496398	100125288	Chemical	Gene	switching|nmod|START_ENTITY switching|nmod|analog analog|compound|END_ENTITY	Efficacy and safety of switching from the DPP-4 inhibitor sitagliptin to the human GLP-1 analog liraglutide after 52 weeks in metformin-treated patients with type 2 diabetes : a randomized , open-label trial .
23523479	0	sitagliptin	80,91	GLP-1	29,34	sitagliptin	GLP-1	MESH:C496398	14526(Tax:10090)	Chemical	Gene	agonist|dobj|START_ENTITY agonist|nsubj|effect effect|nmod|END_ENTITY	Antipsychotic-like effect of GLP-1 agonist liraglutide but not DPP-IV inhibitor sitagliptin in mouse model for psychosis .
24238127	0	sitagliptin	25,36	GLP-1	131,136	sitagliptin	GLP-1	MESH:C496398	24952(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|role role|nmod|END_ENTITY	Renoprotective effect of sitagliptin against hypertensive_nephropathy induced by chronic administration of L-NAME in rats : role of GLP-1 and GLP-1_receptor .
25089625	0	sitagliptin	37,48	GLP-1	14,19	sitagliptin	GLP-1	MESH:C496398	2641	Chemical	Gene	analogues|nmod|START_ENTITY analogues|compound|END_ENTITY	Comparison of GLP-1 analogues versus sitagliptin in the management of type 2 diabetes : systematic review and meta-analysis of head-to-head studies .
17244767	0	sitagliptin	76,87	MK-0431	89,96	sitagliptin	MK-0431	MESH:C496398	1477734(Tax:190192)	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY pharmacokinetics|appos|END_ENTITY	Effect of a single cyclosporine dose on the single-dose pharmacokinetics of sitagliptin -LRB- MK-0431 -RRB- , a dipeptidyl_peptidase-4 inhibitor , in healthy male subjects .
24304575	0	sitagliptin	10,21	adiponectin_receptors_1	122,145	sitagliptin	adiponectin receptors 1	MESH:C496398	289036(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|role role|nmod|END_ENTITY	Effect of sitagliptin on the working memory and reference memory in type 2 diabetic Sprague-Dawley_rats : possible role of adiponectin_receptors_1 .
24843562	0	sitagliptin	32,43	albumin	66,73	sitagliptin	albumin	MESH:C496398	213	Chemical	Gene	START_ENTITY|nmod|level level|compound|END_ENTITY	Estimation of HbA1c response to sitagliptin by change in glycated albumin level for 2 weeks .
16912128	0	sitagliptin	31,42	dipeptidyl_peptidase-4	46,68	sitagliptin	dipeptidyl peptidase-4	MESH:C496398	1803	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effect of single oral doses of sitagliptin , a dipeptidyl_peptidase-4 inhibitor , on incretin and plasma glucose levels after an oral glucose tolerance test in patients with type 2 diabetes .
17001471	0	sitagliptin	60,71	dipeptidyl_peptidase-4	27,49	sitagliptin	dipeptidyl peptidase-4	MESH:C496398	1803	Chemical	Gene	START_ENTITY|nsubj|Efficacy Efficacy|nmod|inhibitor inhibitor|amod|END_ENTITY	Efficacy and safety of the dipeptidyl_peptidase-4 inhibitor sitagliptin as monotherapy in patients with type_2_diabetes_mellitus .
17130196	0	sitagliptin	47,58	dipeptidyl_peptidase-4	14,36	sitagliptin	dipeptidyl peptidase-4	MESH:C496398	1803	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|inhibitor inhibitor|amod|END_ENTITY	Effect of the dipeptidyl_peptidase-4 inhibitor sitagliptin as monotherapy on glycemic control in patients with type 2 diabetes .
17156104	0	sitagliptin	66,77	dipeptidyl_peptidase-4	33,55	sitagliptin	dipeptidyl peptidase-4	MESH:C496398	1803	Chemical	Gene	START_ENTITY|nsubj|Efficacy Efficacy|nmod|inhibitor inhibitor|amod|END_ENTITY	Efficacy and tolerability of the dipeptidyl_peptidase-4 inhibitor sitagliptin as monotherapy over 12 weeks in patients with type 2 diabetes .
17244766	0	sitagliptin	32,43	dipeptidyl_peptidase-4	47,69	sitagliptin	dipeptidyl peptidase-4	MESH:C496398	1803	Chemical	Gene	administration|nmod|START_ENTITY administration|appos|inhibitor inhibitor|amod|END_ENTITY	Multiple-dose administration of sitagliptin , a dipeptidyl_peptidase-4 inhibitor , does not alter the single-dose pharmacokinetics of rosiglitazone in healthy subjects .
17244767	0	sitagliptin	76,87	dipeptidyl_peptidase-4	101,123	sitagliptin	dipeptidyl peptidase-4	MESH:C496398	1803	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY pharmacokinetics|appos|inhibitor inhibitor|amod|END_ENTITY	Effect of a single cyclosporine dose on the single-dose pharmacokinetics of sitagliptin -LRB- MK-0431 -RRB- , a dipeptidyl_peptidase-4 inhibitor , in healthy male subjects .
17300594	0	sitagliptin	17,28	dipeptidyl_peptidase-4	32,54	sitagliptin	dipeptidyl peptidase-4	MESH:C496398	1803	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effect of adding sitagliptin , a dipeptidyl_peptidase-4 inhibitor , to metformin on 24-h glycaemic control and beta-cell function in patients with type 2 diabetes .
17300595	0	sitagliptin	61,72	dipeptidyl_peptidase-4	27,49	sitagliptin	dipeptidyl peptidase-4	MESH:C496398	1803	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Efficacy and safety of the dipeptidyl_peptidase-4 inhibitor , sitagliptin , compared with the sulfonylurea , glipizide , in patients with type 2 diabetes inadequately controlled on metformin alone : a randomized , double-blind , non-inferiority trial .
17314201	0	sitagliptin	50,61	dipeptidyl_peptidase-4	17,39	sitagliptin	dipeptidyl peptidase-4	MESH:C496398	1803	Chemical	Gene	START_ENTITY|nsubj|Transport Transport|nmod|inhibitor inhibitor|amod|END_ENTITY	Transport of the dipeptidyl_peptidase-4 inhibitor sitagliptin by human organic_anion_transporter_3 , _ organic_anion_transporting_polypeptide_4C1 , and multidrug resistance P-glycoprotein .
17559733	0	sitagliptin	11,22	dipeptidyl_peptidase-4	26,48	sitagliptin	dipeptidyl peptidase-4	MESH:C496398	1803	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Once-daily sitagliptin , a dipeptidyl_peptidase-4 inhibitor , for the treatment of patients with type 2 diabetes .
17571284	0	sitagliptin	45,56	dipeptidyl_peptidase-4	78,100	sitagliptin	dipeptidyl peptidase-4	MESH:C496398	1803	Chemical	Gene	formulation|compound|START_ENTITY formulation|appos|inhibitor inhibitor|amod|END_ENTITY	Dose-proportionality of a final market image sitagliptin formulation , an oral dipeptidyl_peptidase-4 inhibitor , in healthy volunteers .
17575559	0	sitagliptin	28,39	dipeptidyl_peptidase-4	49,71	sitagliptin	dipeptidyl peptidase-4	MESH:C496398	1803	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Absolute bioavailability of sitagliptin , an oral dipeptidyl_peptidase-4 inhibitor , in healthy volunteers .
17593236	0	sitagliptin	61,72	dipeptidyl_peptidase-4	27,49	sitagliptin	dipeptidyl peptidase-4	MESH:C496398	1803	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Efficacy and safety of the dipeptidyl_peptidase-4 inhibitor , sitagliptin , in patients with type_2_diabetes_mellitus inadequately controlled on glimepiride alone or on glimepiride and metformin .
18353996	0	sitagliptin	10,21	dipeptidyl_peptidase-4	25,47	sitagliptin	dipeptidyl peptidase-4	MESH:C496398	1803	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effect of sitagliptin , a dipeptidyl_peptidase-4 inhibitor , on blood pressure in nondiabetic patients with mild to moderate hypertension .
18476982	0	sitagliptin	10,21	dipeptidyl_peptidase-4	25,47	sitagliptin	dipeptidyl peptidase-4	MESH:C496398	1803	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effect of sitagliptin , a dipeptidyl_peptidase-4 inhibitor , on beta-cell function in patients with type 2 diabetes : a model-based approach .
20332588	0	sitagliptin	25,36	dipeptidyl_peptidase-4	40,62	sitagliptin	dipeptidyl peptidase-4	MESH:C496398	1803	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Dose-ranging efficacy of sitagliptin , a dipeptidyl_peptidase-4 inhibitor , in Japanese patients with type_2_diabetes_mellitus .
21284702	0	sitagliptin	105,116	dipeptidyl_peptidase-4	45,67	sitagliptin	dipeptidyl peptidase-4	MESH:C496398	1803	Chemical	Gene	doses|nmod|START_ENTITY inhibition|nmod|doses inhibition|amod|END_ENTITY	Evaluation of pharmacokinetic parameters and dipeptidyl_peptidase-4 inhibition following single doses of sitagliptin in healthy , young Japanese males .
21747318	0	sitagliptin	132,143	dipeptidyl_peptidase-4	104,126	sitagliptin	dipeptidyl peptidase-4	MESH:C496398	13482(Tax:10090)	Chemical	Gene	pancreatectomized|nmod|START_ENTITY pancreatectomized|nmod|inhibition inhibition|nmod|END_ENTITY	Improved outcome of islet transplantation in partially pancreatectomized diabetic mice by inhibition of dipeptidyl_peptidase-4 with sitagliptin .
23062489	0	sitagliptin	36,47	dipeptidyl_peptidase-4	2,24	sitagliptin	dipeptidyl peptidase-4	MESH:C496398	1803	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	A dipeptidyl_peptidase-4 inhibitor , sitagliptin , exerts anti-inflammatory effects in type 2 diabetic patients .
23320436	0	sitagliptin	86,97	dipeptidyl_peptidase-4	27,49	sitagliptin	dipeptidyl peptidase-4	MESH:C496398	1803	Chemical	Gene	gemigliptin|nmod|START_ENTITY gemigliptin|amod|END_ENTITY	Efficacy and safety of the dipeptidyl_peptidase-4 inhibitor gemigliptin compared with sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone .
24142388	0	sitagliptin	14,25	dipeptidyl_peptidase-4	36,58	sitagliptin	dipeptidyl peptidase-4	MESH:C496398	1803	Chemical	Gene	effect|compound|START_ENTITY Modelling|dobj|effect Modelling|nmod|activity activity|amod|END_ENTITY	Modelling the sitagliptin effect on dipeptidyl_peptidase-4 activity in adults with haematological malignancies after umbilical cord blood haematopoietic cell transplantation .
24503784	0	sitagliptin	47,58	dipeptidyl_peptidase-4	8,30	sitagliptin	dipeptidyl peptidase-4	MESH:C496398	1803	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Chronic dipeptidyl_peptidase-4 inhibition with sitagliptin is associated with sustained protection against ischemic_left_ventricular_dysfunction in a pilot study of patients with type_2_diabetes_mellitus and coronary_artery_disease .
24843604	0	sitagliptin	116,127	dipeptidyl_peptidase-4	131,153	sitagliptin	dipeptidyl peptidase-4	MESH:C496398	13482(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Oral therapy for type ___ 1_diabetes_mellitus using a novel immunomodulator , FTY720 -LRB- fingolimod -RRB- , in combination with sitagliptin , a dipeptidyl_peptidase-4 inhibitor , examined in non-obese diabetic mice .
26467280	0	sitagliptin	45,56	dipeptidyl_peptidase-4	60,82	sitagliptin	dipeptidyl peptidase-4	MESH:C496398	1803	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Reduction of serum concentration of FABP4 by sitagliptin , a dipeptidyl_peptidase-4 inhibitor , in patients with type_2_diabetes_mellitus .
26873580	0	sitagliptin	70,81	dipeptidyl_peptidase-4	96,118	sitagliptin	dipeptidyl peptidase-4	MESH:C496398	1803	Chemical	Gene	quantitation|nmod|START_ENTITY methods|nmod|quantitation review|nmod|methods review|appos|inhibitor inhibitor|amod|END_ENTITY	A concise review of the bioanalytical methods for the quantitation of sitagliptin , an important dipeptidyl_peptidase-4 -LRB- DPP4 -RRB- inhibitor , utilized for the pharmacokinetic characterization of the drug .
16490580	0	sitagliptin	73,84	dipeptidyl_peptidase-IV	88,111	sitagliptin	dipeptidyl peptidase-IV	MESH:C496398	1803	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Pharmacokinetic and pharmacodynamic properties of multiple oral doses of sitagliptin , a dipeptidyl_peptidase-IV inhibitor : a double-blind , randomized , placebo-controlled study in healthy male volunteers .
22519909	0	sitagliptin	61,72	dipeptidyl_peptidase-IV	26,49	sitagliptin	dipeptidyl peptidase-IV	MESH:C496398	1803	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Combined treatment with a dipeptidyl_peptidase-IV inhibitor -LRB- sitagliptin -RRB- and an angiotensin_II_type_1_receptor blocker -LRB- losartan -RRB- promotes islet regeneration via enhanced differentiation of pancreatic progenitor cells .
26397061	0	sitagliptin	62,73	dipeptidyl_peptidase-IV	27,50	sitagliptin	dipeptidyl peptidase-IV	MESH:C496398	13482(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Therapeutic effects of the dipeptidyl_peptidase-IV inhibitor , sitagliptin , on non-alcoholic_steatohepatitis in FLS-ob/ob male mice .
17220241	0	sitagliptin	52,63	dipeptidyl_peptidase_4	19,41	sitagliptin	dipeptidyl peptidase 4	MESH:C496398	25253(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Disposition Disposition|nmod|inhibitor inhibitor|amod|END_ENTITY	Disposition of the dipeptidyl_peptidase_4 inhibitor sitagliptin in rats and dogs .
16338283	0	sitagliptin	41,52	dipeptidyl_peptidase_IV	70,93	sitagliptin	dipeptidyl peptidase IV	MESH:C496398	1803	Chemical	Gene	Pharmacokinetics|nmod|START_ENTITY Pharmacokinetics|appos|inhibitor inhibitor|nmod|END_ENTITY	Pharmacokinetics and pharmacodynamics of sitagliptin , an inhibitor of dipeptidyl_peptidase_IV , in healthy subjects : results from two randomized , double-blind , placebo-controlled studies with single oral doses .
22151893	0	sitagliptin	60,71	dipeptidyl_peptidase_IV	26,49	sitagliptin	dipeptidyl peptidase IV	MESH:C496398	25253(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Protective effects of the dipeptidyl_peptidase_IV inhibitor sitagliptin in the blood-retinal barrier in a type 2 diabetes animal model .
22186413	0	sitagliptin	65,76	dipeptidylpeptidase-IV	31,53	sitagliptin	dipeptidylpeptidase-IV	MESH:C496398	1803	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Novel biological action of the dipeptidylpeptidase-IV inhibitor , sitagliptin , as a glucagon-like_peptide-1 secretagogue .
26806752	0	sitagliptin	26,37	early_growth_response-1	56,79	sitagliptin	early growth response-1	MESH:C496398	13653(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expressions expressions|nmod|END_ENTITY	-LSB- Effect of DPP4 inhibitor sitagliptin on expressions of early_growth_response-1 and fibronectin in the kidney of ApoE gene knockout mice -RSB- .
24525293	0	sitagliptin	30,41	insulin	45,52	sitagliptin	insulin	MESH:C496398	3630	Chemical	Gene	adding|dobj|START_ENTITY adding|nmod|END_ENTITY	Safety and efficacy of adding sitagliptin to insulin in patients with type 2 diabetes : the ASSIST-K study .
25598351	0	sitaxentan	48,58	endothelin_A_receptor	10,31	sitaxentan	endothelin A receptor	null	13617(Tax:10090)	Chemical	Gene	antagonism|nmod|START_ENTITY antagonism|compound|END_ENTITY	Selective endothelin_A_receptor antagonism with sitaxentan reduces neointimal lesion size in a mouse model of intraluminal_injury .
25795151	0	sitosterol	85,95	ApoE	99,103	sitosterol	ApoE	MESH:C025473	11816(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	7b-Hydroxysitosterol crosses the blood-brain barrier more favored than its substrate sitosterol in ApoE - / - mice .
17440528	0	sitosterol	75,85	familial_hypercholesterolemia	103,132	sitosterol	familial hypercholesterolemia	MESH:C025473	3949	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	Basal plasma concentrations of plant sterols can predict LDL-C response to sitosterol in patients with familial_hypercholesterolemia .
19464305	0	sitosteryl_esters	66,83	cholesterol_esterase	42,62	sitosteryl esters	cholesterol esterase	null	1056	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of oxidation on the hydrolysis by cholesterol_esterase of sitosteryl_esters as compared to a cholesteryl_ester .
16897233	0	sivelestat	11,21	IL-8	52,56	sivelestat	IL-8	MESH:C069195	3576	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|production production|amod|END_ENTITY	Effects of sivelestat , a new elastase inhibitor , on IL-8 and MCP-1 production from stimulated human alveolar epithelial type II cells .
20976506	0	sivelestat	23,33	interleukin_8	37,50	sivelestat	interleukin 8	MESH:C069195	3576	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|production production|amod|END_ENTITY	Suppressive effects of sivelestat on interleukin_8 and TNF-a production from LPS-stimulated granulocytes in whole blood culture .
18298955	0	smilagenin	75,85	glial_cell_derived_neurotrophic_factor	8,46	smilagenin	glial cell derived neurotrophic factor	MESH:C046297	25453(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of glial_cell_derived_neurotrophic_factor in the protective effect of smilagenin on rat mesencephalic dopaminergic neurons damaged by MPP + .
21566972	0	sn-38	77,82	cpt-11	128,134	sn-38	cpt-11	MESH:C051890	963084(Tax:115711)	Chemical	Gene	START_ENTITY|appos|metabolite metabolite|nmod|END_ENTITY	Bcl-2 gene prevents induction of apoptosis in l1210 murine leukemia-cells by sn-38 , a metabolite of the camptothecin derivative cpt-11 .
9291199	0	sodium	67,73	ACE	109,112	sodium	ACE	MESH:D012964	1636	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|compound|END_ENTITY	Autonomy of the renin system in type_II_diabetes_mellitus : dietary sodium and renal hemodynamic responses to ACE inhibition .
21546577	1	sodium	216,222	AF17	201,205	sodium	Af17	MESH:D012964	246198(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY modulates|dobj|homeostasis modulates|nsubj|END_ENTITY	The putative transcription factor AF17 upregulates the transcription of the epithelial_sodium_channel -LRB- ENaC -RRB- genes , but whether AF17 modulates sodium homeostasis and BP is unknown .
2970230	0	sodium	10,16	ANF	64,67	sodium	ANF	MESH:D012964	24602(Tax:10116)	Chemical	Gene	intake|compound|START_ENTITY Effect|nmod|intake Effect|nmod|END_ENTITY	Effect of sodium intake on gene expression and plasma levels of ANF in rats .
22846885	0	sodium	37,43	ANG_II	21,27	sodium	ANG II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	depletion|compound|START_ENTITY END_ENTITY|nmod|depletion	Involvement of brain ANG_II in acute sodium depletion induced salty taste changes .
1535756	0	sodium	26,32	ANP	19,22	sodium	ANP	MESH:D012964	24602(Tax:10116)	Chemical	Gene	excretion|compound|START_ENTITY END_ENTITY|nmod|excretion	Role of endogenous ANP in sodium excretion in rats with experimental pulmonary_hypertension .
1838024	0	sodium	48,54	ANP	24,27	sodium	ANP	MESH:D012964	4878	Chemical	Gene	transport|compound|START_ENTITY mechanisms|nmod|transport mechanisms|nmod|inhibition inhibition|compound|END_ENTITY	Molecular mechanisms of ANP inhibition of renal sodium transport .
2147645	0	sodium	116,122	ANP	88,91	sodium	ANP	MESH:D012964	4878	Chemical	Gene	excretion|nmod|START_ENTITY aldosterone|dobj|excretion aldosterone|dep|END_ENTITY	Effect of acute water loading on plasma levels of antidiuretic_hormone AVP aldosterone , ANP fractional excretion of sodium and plasma and urine osmolalities in myxedema .
2942748	0	sodium	66,72	ANP	51,54	sodium	ANP	MESH:D012964	24602(Tax:10116)	Chemical	Gene	load|compound|START_ENTITY polypeptide|nmod|load polypeptide|appos|END_ENTITY	Increase in plasma atrial natriuretic polypeptide -LRB- ANP -RRB- following sodium load in anesthetized rats .
7770642	0	sodium	57,63	ANP	12,15	sodium	ANP	MESH:D012964	24602(Tax:10116)	Chemical	Gene	loading|compound|START_ENTITY acute|nmod|loading release|nmod|acute release|nsubj|END_ENTITY	Age-related ANP release in response to acute vs. chronic sodium loading .
16749855	0	sodium	7,13	ASBT	47,51	sodium	ASBT	MESH:D012964	6555	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Apical sodium dependent bile_acid transporter -LRB- ASBT , SLC10A2 -RRB- : a potential prodrug target .
21976025	0	sodium	60,66	ASBT	77,81	sodium	ASBT	MESH:D012964	6555	Chemical	Gene	symporter|compound|START_ENTITY homologue|nmod|symporter structure|nmod|homologue END_ENTITY|nsubj|structure	Crystal structure of a bacterial homologue of the bile_acid sodium symporter ASBT .
7498983	8	sodium	1283,1289	AT1A	1311,1315	sodium	AT1A	MESH:D012964	24180(Tax:10116)	Chemical	Gene	deficiency|compound|START_ENTITY increases|nsubj|deficiency increases|dobj|mRNA mRNA|compound|END_ENTITY	Thus , sodium deficiency increases AT1A mRNA in both kidney and adrenal gland , while Ang II receptor blockade by losartan prevents low sodium-induced AT1A mRNA only in adrenal gland .
15246823	0	sodium	8,14	AT1a	37,41	sodium	AT1a	MESH:D012964	11607(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Dietary sodium regulates angiotensin AT1a and AT1b mRNA expression in mouse brain .
1533602	0	sodium	66,72	ATPase	83,89	sodium	ATPase	MESH:D012964	3654511(Tax:562)	Chemical	Gene	dependent|advmod|START_ENTITY END_ENTITY|amod|dependent	Characterization of the genes coding for the F1F0 subunits of the sodium dependent ATPase of Propionigenium modestum .
215214	0	sodium	41,47	ATPase	68,74	sodium	ATPase	MESH:D012964	1769	Chemical	Gene	ions|nmod|START_ENTITY Activation|nmod|ions sites|amod|Activation sites|dep|END_ENTITY	Activation by lithium ions of the inside sodium sites in -LRB- Na + + K + -RRB- - ATPase .
4248677	0	sodium	76,82	ATPase	23,29	sodium	ATPase	MESH:D012964	1769	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|nmod|transport	-LRB- Na plus minus K plus -RRB- - ATPase from the frog bladder and its relationship to sodium transport .
4284530	0	sodium	4,10	ATPase	35,41	sodium	ATPase	MESH:D012964	1769	Chemical	Gene	activated|nsubj|START_ENTITY activated|dobj|END_ENTITY	The sodium and potassium activated ATPase of intestinal epithelium .
6248505	0	sodium	57,63	ATPase	88,94	sodium	ATPase	MESH:D012964	1769	Chemical	Gene	solubilization|nmod|START_ENTITY agents|nmod|solubilization dependent|nsubj|agents reducing|xcomp|dependent Effect|acl|reducing END_ENTITY|nsubj|Effect	Effect of reducing agents on the solubilization of renal sodium and potassium dependent ATPase with detergent .
6254923	5	sodium	856,862	ATPase	720,726	sodium	ATPase	MESH:D012964	1769	Chemical	Gene	content|compound|START_ENTITY increased|nsubj|content increased|advcl|has has|dobj|potential potential|nmod|END_ENTITY	Because adriamycin has the potential of inhibiting ATPase , including both Na-K-dependent ATPase and ouabain insensitive ATPase , at concentrations not inhibitory to other enzymes , the net sodium content increased , and potassium content decreased after incubation of red cells with adriamycin at high concentrations .
6259330	0	sodium	36,42	ATPase	54,60	sodium	ATPase	MESH:D012964	1769	Chemical	Gene	potassium|amod|START_ENTITY cell|appos|potassium END_ENTITY|nsubj|cell	Excess magnesium converts red cell -LRB- sodium + potassium -RRB- ATPase to the potassium phosphatase .
9642181	0	sodium	75,81	ATPase	40,46	sodium	ATPase	MESH:D012964	1769	Chemical	Gene	ion|compound|START_ENTITY pump|nsubj|ion pump|ccomp|tartaricus tartaricus|nsubj|Purification Purification|nmod|END_ENTITY	Purification and properties of the F1F0 ATPase of Ilyobacter tartaricus , a sodium ion pump .
3013653	0	sodium	67,73	Angiotensin-converting_enzyme	0,29	sodium	Angiotensin-converting enzyme	MESH:D012964	24310(Tax:10116)	Chemical	Gene	rat|compound|START_ENTITY enalapril|nmod|rat responses|nmod|enalapril responses|amod|END_ENTITY	Angiotensin-converting_enzyme responses following enalapril in the sodium deficient rat .
10988274	0	sodium	140,146	Angiotensin_II	0,14	sodium	Angiotensin II	MESH:D012964	183	Chemical	Gene	diet|compound|START_ENTITY associated|nmod|diet associated|nsubjpass|sensitivity sensitivity|compound|END_ENTITY	Angiotensin_II sensitivity is associated with the angiotensin_II_type_1_receptor A -LRB- 1166 -RRB- C polymorphism in essential hypertensives on a high sodium diet .
1708907	0	sodium	35,41	Angiotensin_II	0,14	sodium	Angiotensin II	MESH:D012964	183	Chemical	Gene	transport|compound|START_ENTITY tubule|dobj|transport tubule|nsubj|END_ENTITY	Angiotensin_II and proximal tubule sodium transport .
18633183	0	sodium	90,96	Angiotensin_II	0,14	sodium	Angiotensin II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	overload|compound|START_ENTITY submitted|nmod|overload rats|acl|submitted transforming_growth_factor-beta1|nmod|rats intrarenal|xcomp|transforming_growth_factor-beta1 intrarenal|nsubj|increases increases|compound|END_ENTITY	Angiotensin_II increases intrarenal transforming_growth_factor-beta1 in rats submitted to sodium overload independently of blood pressure .
1886454	0	sodium	59,65	Angiotensin_II	0,14	sodium	Angiotensin II	MESH:D012964	183	Chemical	Gene	restriction|compound|START_ENTITY evoked|nmod|restriction activity|acl|evoked mediates|dobj|activity mediates|nsubj|END_ENTITY	Angiotensin_II mediates hyperadrenergic activity evoked by sodium restriction in essential hypertension .
21282553	0	sodium	124,130	Angiotensin_II	0,14	sodium	Angiotensin II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY kinase|nmod|channel cells|nmod|kinase collecting|dobj|cells medullary|acl|collecting stimulates|nmod|medullary stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates renin in inner medullary collecting duct cells via protein kinase C and independent of epithelial sodium channel and mineralocorticoid receptor activity .
2185149	0	sodium	41,47	Angiotensin_II	0,14	sodium	Angiotensin II	MESH:D012964	183	Chemical	Gene	transport|compound|START_ENTITY controller|nmod|transport END_ENTITY|dep|controller	Angiotensin_II : a powerful controller of sodium transport in the early proximal tubule .
4331800	0	sodium	68,74	Angiotensin_II	0,14	sodium	Angiotensin II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	avidity|nmod|START_ENTITY balance|amod|avidity receptors|dep|balance receptors|compound|END_ENTITY	Angiotensin_II vascular receptors : their avidity in relationship to sodium balance , the autonomic nervous system , and hypertension .
620496	0	sodium	48,54	Angiotensin_II	0,14	sodium	Angiotensin II	MESH:D012964	183	Chemical	Gene	depletion|compound|START_ENTITY marked|dobj|depletion marked|nsubj|blockade blockade|compound|END_ENTITY	Angiotensin_II blockade before and after marked sodium depletion in patients with hypertension .
6385344	0	sodium	77,83	Angiotensin_II	0,14	sodium	Angiotensin II	MESH:D012964	183	Chemical	Gene	intake|compound|START_ENTITY END_ENTITY|nmod|intake	Angiotensin_II analogue infusion test in renovascular_hypertension under low sodium intake and under spironolactone administration : is angiotensin_II analogue infusion test useful in determining the mode of treatment ?
7614037	0	sodium	76,82	Angiotensin_II	0,14	sodium	Angiotensin II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	loading|compound|START_ENTITY binding|nmod|loading binding|nsubj|END_ENTITY	Angiotensin_II binding sites in the rat pancreas and their modulation after sodium loading and depletion .
8304488	0	sodium	78,84	Angiotensin_II	0,14	sodium	Angiotensin II	MESH:D012964	183	Chemical	Gene	load|compound|START_ENTITY excretion|nmod|load permitting|dobj|excretion factor|acl|permitting factor|nsubj|suppression suppression|compound|END_ENTITY	Angiotensin_II suppression is a major factor permitting excretion of an acute sodium load in humans .
8591892	0	sodium	63,69	Angiotensin_II	0,14	sodium	Angiotensin II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|dep|effects	Angiotensin_II and angiotensin - -LRB- 1-7 -RRB- effects on free cytosolic sodium , intracellular pH , and the Na -LRB- + -RRB- - H + antiporter in vascular smooth muscle .
8822984	0	sodium	26,32	Angiotensin_II	0,14	sodium	Angiotensin II	MESH:D012964	183	Chemical	Gene	modulates|compound|START_ENTITY related|nmod|modulates END_ENTITY|acl|related	Angiotensin_II related to sodium excretion modulates left ventricular structure in human essential hypertension .
11950515	0	sodium	28,34	Ankyrin_G	0,9	sodium	Ankyrin G	MESH:D012964	288	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Ankyrin_G and voltage gated sodium channels colocalize in human neuroma -- key proteins of membrane remodeling after axonal_injury .
2146893	0	sodium	62,68	Atrial_natriuretic_factor	0,25	sodium	Atrial natriuretic factor	MESH:D012964	608289(Tax:9615)	Chemical	Gene	role|nmod|START_ENTITY control|dep|role control|compound|END_ENTITY	Atrial_natriuretic_factor and blood pressure control : role of sodium and aldosterone .
2940876	0	sodium	35,41	Atrial_natriuretic_factor	0,25	sodium	Atrial natriuretic factor	MESH:D012964	24602(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY inhibits|dobj|transport inhibits|nsubj|END_ENTITY	Atrial_natriuretic_factor inhibits sodium transport in medullary collecting duct .
8467324	0	sodium	87,93	Atrial_natriuretic_factor	0,25	sodium	Atrial natriuretic factor	MESH:D012964	608289(Tax:9615)	Chemical	Gene	II|nmod|START_ENTITY response|nmod|II END_ENTITY|nmod|response	Atrial_natriuretic_factor and changes in the aldosterone response to angiotensin II in sodium depleted dogs .
1324615	0	sodium	56,62	Atrial_natriuretic_peptide	0,26	sodium	Atrial natriuretic peptide	MESH:D012964	24602(Tax:10116)	Chemical	Gene	uptake|compound|START_ENTITY inhibits|dobj|uptake inhibits|nsubj|END_ENTITY	Atrial_natriuretic_peptide inhibits amiloride-sensitive sodium uptake in rat brain .
1649865	0	sodium	77,83	Atrial_natriuretic_peptide	0,26	sodium	Atrial natriuretic peptide	MESH:D012964	24602(Tax:10116)	Chemical	Gene	restriction|compound|START_ENTITY induced|nmod|restriction induced|nsubj|END_ENTITY	Atrial_natriuretic_peptide during the elevation in blood pressure induced by sodium restriction .
2533680	0	sodium	67,73	Atrial_natriuretic_peptide	0,26	sodium	Atrial natriuretic peptide	MESH:D012964	24602(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY has|dobj|effect has|nsubj|END_ENTITY	Atrial_natriuretic_peptide has no direct effect on proximal tubule sodium and water reabsorption .
2951600	0	sodium	76,82	Atrial_natriuretic_peptide	0,26	sodium	Atrial natriuretic peptide	MESH:D012964	24602(Tax:10116)	Chemical	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Atrial_natriuretic_peptide inhibits angiotensin-stimulated proximal tubular sodium and water reabsorption .
17576410	0	sodium	30,36	BACE1	0,5	sodium	BACE1	MESH:D012964	23621	Chemical	Gene	channels|compound|START_ENTITY regulates|dobj|channels regulates|nsubj|END_ENTITY	BACE1 regulates voltage-gated sodium channels and neuronal activity .
10565577	0	sodium	14,20	CA1	37,40	sodium	CA1	MESH:D012964	310218(Tax:10116)	Chemical	Gene	currents|compound|START_ENTITY currents|nmod|END_ENTITY	Modulation of sodium currents in rat CA1 neurons by carbamazepine and valproate after kindling epileptogenesis .
12020868	0	sodium	36,42	CA1	90,93	sodium	CA1	MESH:D012964	310218(Tax:10116)	Chemical	Gene	current|compound|START_ENTITY current|nmod|neurons neurons|compound|END_ENTITY	Radix paeoniae rubra suppression of sodium current in acutely dissociated rat hippocampal CA1 neurons .
12075477	0	sodium	30,36	CA1	82,85	sodium	CA1	MESH:D012964	310218(Tax:10116)	Chemical	Gene	currents|compound|START_ENTITY currents|nmod|END_ENTITY	-LSB- Effect of SO2 derivatives on sodium currents in acutely isolated rat hippocampal CA1 neurons -RSB- .
12611966	0	sodium	69,75	CA1	105,108	sodium	CA1	MESH:D012964	310218(Tax:10116)	Chemical	Gene	currents|compound|START_ENTITY currents|nmod|neurons neurons|compound|END_ENTITY	Relation between bicarbonate concentration and voltage dependence of sodium currents in freshly isolated CA1 neurons of the rat .
14643012	0	sodium	19,25	CA1	62,65	sodium	CA1	MESH:D012964	310218(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|nmod|END_ENTITY	The sensitivity of sodium channels in immature and mature rat CA1 neurones to the local anaesthetics procaine and lidocaine .
17112406	0	sodium	65,71	CA1	88,91	sodium	CA1	MESH:D012964	310218(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|nmod|END_ENTITY	Kinetic changes and modulation by carbamazepine on voltage-gated sodium channels in rat CA1 neurons after epilepsy .
18367338	0	sodium	72,78	CA1	107,110	sodium	CA1	MESH:D012964	310218(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|nmod|neurons neurons|compound|END_ENTITY	Developmental exposure to lead causes inherent changes on voltage-gated sodium channels in rat hippocampal CA1 neurons .
19277862	0	sodium	34,40	CA1	82,85	sodium	CA1	MESH:D012964	310218(Tax:10116)	Chemical	Gene	currents|compound|START_ENTITY currents|nmod|neurons neurons|compound|END_ENTITY	Enhancement of lanthanum _ -LRB- III -RRB- on sodium currents in acutely isolated hippocampal CA1 neurons of rat .
19683029	0	sodium	81,87	CA1	111,114	sodium	CA1	MESH:D012964	759	Chemical	Gene	current|compound|START_ENTITY current|nmod|neurons neurons|compound|END_ENTITY	Action potential changes associated with the inhibitory effects on voltage-gated sodium current of hippocampal CA1 neurons by silver nanoparticles .
21218498	0	sodium	33,39	CA1	63,66	sodium	CA1	MESH:D012964	759	Chemical	Gene	current|compound|START_ENTITY current|nmod|neurons neurons|compound|END_ENTITY	Nano-CuO inhibited voltage-gated sodium current of hippocampal CA1 neurons via reactive oxygen species but independent from G-proteins pathway .
22954532	0	sodium	69,75	CA1	99,102	sodium	CA1	MESH:D012964	759	Chemical	Gene	current|compound|START_ENTITY current|nmod|neurons neurons|compound|END_ENTITY	Attenuated effect of tungsten_carbide nanoparticles on voltage-gated sodium current of hippocampal CA1 pyramidal neurons .
25097934	0	sodium	79,85	CA1	97,100	sodium	CA1	MESH:D012964	310218(Tax:10116)	Chemical	Gene	current|compound|START_ENTITY current|nmod|neurons neurons|nummod|END_ENTITY	-LSB- The effect of enzymatic treatment using proteases on properties of persistent sodium current in CA1 pyramidal neurons of rat hippocampus -RSB- .
26552299	0	sodium	30,36	CA1	48,51	sodium	CA1	MESH:D012964	310218(Tax:10116)	Chemical	Gene	current|compound|START_ENTITY current|nmod|neurons neurons|nummod|END_ENTITY	Thrombin modulates persistent sodium current in CA1 pyramidal neurons of young and adult rat hippocampus .
8821477	0	sodium	26,32	CA1	87,90	sodium	CA1	MESH:D012964	310218(Tax:10116)	Chemical	Gene	currents|compound|START_ENTITY currents|nmod|END_ENTITY	The kinetic parameters of sodium currents in maturing acutely isolated rat hippocampal CA1 neurones .
9660889	0	sodium	56,62	CA1	78,81	sodium	CA1	MESH:D012964	310218(Tax:10116)	Chemical	Gene	current|compound|START_ENTITY current|nmod|neurons neurons|compound|END_ENTITY	Inhibition of oxidative metabolism increases persistent sodium current in rat CA1 hippocampal neurons .
22842345	0	sodium	16,22	CD4	74,77	sodium	CD4	MESH:D012964	920	Chemical	Gene	channel|compound|START_ENTITY cells|nsubj|channel cells|amod|essential essential|nmod|selection selection|nmod|T T|compound|END_ENTITY	A voltage-gated sodium channel is essential for the positive selection of CD4 -LRB- + -RRB- T cells .
8741008	0	sodium	16,22	CD4	94,97	sodium	CD4	MESH:D012964	12504(Tax:10090)	Chemical	Gene	START_ENTITY|dep|effects effects|nmod|END_ENTITY	Dextran sulfate sodium -LRB- DSS -RRB- induced experimental colitis in immunodeficient mice : effects in CD4 -LRB- + -RRB- - cell depleted , athymic and NK-cell depleted SCID mice .
7543698	0	sodium	38,44	CFTR	0,4	sodium	CFTR	MESH:D012964	1080	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|nmod|channels	CFTR as a cAMP-dependent regulator of sodium channels .
16513816	0	sodium	41,47	CHX21	23,28	sodium	CHX21	MESH:D012964	817749(Tax:3702)	Chemical	Gene	transporter|compound|START_ENTITY analysis|dep|transporter analysis|nmod|END_ENTITY	Functional analysis of CHX21 : a putative sodium transporter in Arabidopsis .
15471576	0	sodium	27,33	CNG-A3	20,26	sodium	CNG-A3	MESH:D012964	85257(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Modulation of renal CNG-A3 sodium channel in rats subjected to low - and high-sodium diets .
19940265	2	sodium	395,401	COX-2	383,388	sodium	COX-1	MESH:D012964	17708(Tax:10090)	Chemical	Gene	retention|compound|START_ENTITY retention|compound|END_ENTITY	Both traditional nonsteroidal antiinflammatory drugs -LRB- NSAIDs -RRB- that inhibit COX-1 and COX-2 and NSAIDs designed to be selective for inhibition of COX-2 cause sodium retention and elevate blood pressure .
23900806	0	sodium	18,24	COX2	33,37	sodium	COX2	MESH:D012964	19225(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Increased dietary sodium induces COX2 expression by activating NFkB in renal medullary interstitial cells .
6100311	0	sodium	51,57	CSF	47,50	sodium	CSF	MESH:D012964	1437	Chemical	Gene	concentration|compound|START_ENTITY concentration|compound|END_ENTITY	Species differences in the effect of decreased CSF sodium concentration on salt appetite .
21726526	0	sodium	85,91	Calmodulin	0,10	sodium	Calmodulin	MESH:D012964	24242(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY regulate|dobj|channel regulate|nsubj|END_ENTITY	Calmodulin and calcium differentially regulate the neuronal Nav1 .1 voltage-dependent sodium channel .
22180603	0	sodium	21,27	Connexin43	0,10	sodium	Connexin43	MESH:D012964	2697	Chemical	Gene	current|compound|START_ENTITY regulates|dobj|current regulates|nsubj|END_ENTITY	Connexin43 regulates sodium current ; ankyrin-G modulates gap junctions : the intercalated disc exchanger .
23370527	0	sodium	43,49	EGF_receptor	12,24	sodium	EGF receptor	MESH:D012964	1956	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of the EGF_receptor in PPARy-mediated sodium and water transport in human proximal tubule cells .
25455829	0	sodium	14,20	EMT	56,59	sodium	EMT	MESH:D012964	3702	Chemical	Gene	blockade|compound|START_ENTITY blockade|nmod|END_ENTITY	Voltage-gated sodium channel blockade for inhibition of EMT .
20686170	0	sodium	33,39	ENAC	49,53	sodium	ENAC	MESH:D012964	24768(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Increased renal alpha-epithelial sodium channel -LRB- ENAC -RRB- protein and increased ENAC activity in normal pregnancy .
12136266	0	sodium	77,83	ENaC	25,29	sodium	ENaC	MESH:D012964	24768(Tax:10116)	Chemical	Gene	depletion|compound|START_ENTITY subunit|nmod|depletion subunit|nsubj|variability variability|nmod|END_ENTITY	Segmental variability of ENaC subunit expression in rat colon during dietary sodium depletion .
16416336	0	sodium	30,36	ENaC	46,50	sodium	ENaC	MESH:D012964	20276(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Stimulation of the epithelial sodium channel -LRB- ENaC -RRB- by the serum - _ and_glucocorticoid-inducible_kinase -LRB- Sgk -RRB- involves the PY motifs of the channel but is independent of sodium feedback inhibition .
17485228	0	sodium	61,67	ENaC	23,27	sodium	ENaC	MESH:D012964	24768(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|expression expression|nmod|mRNA mRNA|compound|END_ENTITY	Abnormal expression of ENaC and SGK1 mRNA induced by dietary sodium in Dahl salt-sensitively hypertensive rats .
18355814	0	sodium	42,48	ENaC	8,12	sodium	ENaC	MESH:D012964	24768(Tax:10116)	Chemical	Gene	absorption|compound|START_ENTITY leads|nmod|absorption leads|nsubj|expression expression|compound|END_ENTITY	Altered ENaC expression leads to impaired sodium absorption in the noninflamed intestine in Crohn 's _ disease .
18669538	0	sodium	50,56	ENaC	66,70	sodium	ENaC	MESH:D012964	24768(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY subunit|nmod|channel Cleavage|dep|subunit Cleavage|appos|END_ENTITY	Cleavage in the -LCB- gamma -RCB- - subunit of the epithelial sodium channel -LRB- ENaC -RRB- plays an important role in the proteolytic activation of near-silent channels .
19864949	2	sodium	225,231	ENaC	241,245	sodium	ENaC	MESH:D012964	20276(Tax:10090)	Chemical	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Perturbations in epithelial sodium channel -LRB- ENaC -RRB- activity disrupt volume homeostasis .
23171553	0	sodium	41,47	ENaC	23,27	sodium	ENaC	MESH:D012964	24768(Tax:10116)	Chemical	Gene	loading|compound|START_ENTITY Feedback|nmod|loading Feedback|dobj|inhibition inhibition|nmod|END_ENTITY	Feedback inhibition of ENaC during acute sodium loading in vivo .
23222417	0	sodium	30,36	ENaC	122,126	sodium	ENaC	MESH:D012964	24768(Tax:10116)	Chemical	Gene	stimulation|nmod|START_ENTITY reabsorption|nsubj|stimulation reabsorption|nmod|activation activation|nmod|epithelial_sodium_channel epithelial_sodium_channel|appos|END_ENTITY	Protease stimulation of renal sodium reabsorption in vivo by activation of the collecting duct epithelial_sodium_channel -LRB- ENaC -RRB- .
26154487	0	sodium	111,117	ENaC	128,132	sodium	ENaC	MESH:D012964	24768(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Estrogen , progesterone , and genistein differentially regulate levels of expression of a - , b - , and y-epithelial sodium channel -LRB- ENaC -RRB- and a-sodium_potassium pump -LRB- Na -LRB- + -RRB- / K -LRB- + -RRB- - ATPase -RRB- in the uteri of sex steroid-deficient rats .
15634742	0	sodium	78,84	ERK1/2	11,17	sodium	ERK1/2	MESH:D012964	26417;26413	Chemical	Gene	absorption|compound|START_ENTITY role|nmod|absorption role|nmod|END_ENTITY	A role for ERK1/2 in EGF - and ATP-dependent regulation of amiloride-sensitive sodium absorption .
11169461	0	sodium	60,66	Epidermal_growth_factor	0,23	sodium	Epidermal growth factor	MESH:D012964	1950	Chemical	Gene	absorption|compound|START_ENTITY regulates|nmod|absorption regulates|nsubj|END_ENTITY	Epidermal_growth_factor regulates the transition from basal sodium absorption to anion secretion in cultured endometrial epithelial cells .
12388407	0	sodium	53,59	Epidermal_growth_factor	0,23	sodium	Epidermal growth factor	MESH:D012964	13645(Tax:10090)	Chemical	Gene	absorption|compound|START_ENTITY inhibits|dobj|absorption inhibits|nsubj|END_ENTITY	Epidermal_growth_factor inhibits amiloride-sensitive sodium absorption in renal collecting duct cells .
18036246	0	sodium	133,139	Epidermal_growth_factor	0,23	sodium	Epidermal growth factor	MESH:D012964	1950	Chemical	Gene	channel|compound|START_ENTITY involvement|nmod|channel potentiates|dep|involvement potentiates|amod|END_ENTITY	Epidermal_growth_factor potentiates in vitro metastatic behaviour of human prostate_cancer PC-3M cells : involvement of voltage-gated sodium channel .
17214984	0	sodium	18,24	Fos	32,35	sodium	Fos	MESH:D012964	314322(Tax:10116)	Chemical	Gene	alters|nsubj|START_ENTITY alters|dobj|expression expression|compound|END_ENTITY	Increased dietary sodium alters Fos expression in the lamina terminalis during intravenous angiotensin_II infusion .
14761863	0	sodium	11,17	Gamma-MSH	0,9	sodium	Gamma-MSH	MESH:D012964	5443	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|appos|metabolism	Gamma-MSH , sodium metabolism , and salt-sensitive hypertension .
21698800	0	sodium	27,33	IL-1b	18,23	sodium	IL-1b	MESH:D012964	24494(Tax:10116)	Chemical	Gene	current|compound|START_ENTITY END_ENTITY|nmod|current	-LSB- Acute effects of IL-1b on sodium current in cortical neurons of rats -RSB- .
15063785	0	sodium	31,37	IL-1beta	0,8	sodium	IL-1beta	MESH:D012964	24494(Tax:10116)	Chemical	Gene	absorption|compound|START_ENTITY regulate|dobj|absorption regulate|nsubj|END_ENTITY	IL-1beta and TNFalpha regulate sodium absorption in rat distal colon .
10498674	0	sodium	35,41	Insulin	0,7	sodium	Insulin	MESH:D012964	3630	Chemical	Gene	transport|compound|START_ENTITY stimulates|dobj|transport stimulates|nsubj|END_ENTITY	Insulin stimulates transepithelial sodium transport by activation of a protein phosphatase that increases Na-K ATPase activity in endometrial epithelial cells .
10528658	0	sodium	141,147	Insulin	0,7	sodium	Insulin	MESH:D012964	3630	Chemical	Gene	correlation|compound|START_ENTITY effects|nmod|correlation correlate|advcl|effects correlate|nsubj|effects effects|nmod:poss|END_ENTITY	Insulin 's acute effects on glomerular filtration rate correlate with insulin_sensitivity whereas insulin 's acute effects on proximal tubular sodium reabsorption correlation with salt sensitivity in normal subjects .
10778592	0	sodium	44,50	Insulin	0,7	sodium	Insulin	MESH:D012964	3630	Chemical	Gene	resistance|nmod|START_ENTITY resistance|amod|END_ENTITY	Insulin resistance and urinary excretion of sodium in hypertensive patients with non-insulin dependent diabetes_mellitus .
17686957	0	sodium	26,32	Insulin	0,7	sodium	Insulin	MESH:D012964	3630	Chemical	Gene	transport|amod|START_ENTITY impact|nmod|transport impact|nmod:poss|END_ENTITY	Insulin 's impact on renal sodium transport and blood pressure in health , obesity , and diabetes .
177880	0	sodium	26,32	Insulin	0,7	sodium	Insulin	MESH:D012964	3630	Chemical	Gene	transport|compound|START_ENTITY stimulates|dobj|transport stimulates|nsubj|END_ENTITY	Insulin stimulates active sodium transport in toad bladder by two mechanisms .
1942773	0	sodium	18,24	Insulin	0,7	sodium	Insulin	MESH:D012964	3630	Chemical	Gene	reabsorption|compound|START_ENTITY increases|dobj|reabsorption increases|nsubj|END_ENTITY	Insulin increases sodium reabsorption in diluting segment in humans : evidence for indirect mediation through hypokalemia .
2676858	0	sodium	18,24	Insulin	0,7	sodium	Insulin	MESH:D012964	3630	Chemical	Gene	retention|compound|START_ENTITY retention|compound|END_ENTITY	Insulin and renal sodium retention in obese adolescents .
7016790	0	sodium	18,24	Insulin	0,7	sodium	Insulin	MESH:D012964	3630	Chemical	Gene	handling|compound|START_ENTITY handling|compound|END_ENTITY	Insulin and renal sodium handling : clinical implications .
7498974	0	sodium	24,30	Insulin	0,7	sodium	Insulin	MESH:D012964	3630	Chemical	Gene	effect|nmod|START_ENTITY effect|compound|END_ENTITY	Insulin effect on renal sodium reabsorption in adolescent offspring of essential hypertensive parents .
7967348	0	sodium	79,85	Insulin	0,7	sodium	Insulin	MESH:D012964	3630	Chemical	Gene	sites|compound|START_ENTITY affinity|nmod|sites decreases|dobj|affinity activation|parataxis|decreases activation|compound|END_ENTITY	Insulin activation of red blood cell Na + / H + exchange decreases the affinity of sodium sites .
8125556	0	sodium	18,24	Insulin	0,7	sodium	Insulin	MESH:D012964	3630	Chemical	Gene	retention|compound|START_ENTITY retention|compound|END_ENTITY	Insulin and renal sodium retention in hypertension-prone men .
8282372	0	sodium	56,62	Insulin	0,7	sodium	Insulin	MESH:D012964	3630	Chemical	Gene	handling|compound|START_ENTITY sensitivity|nmod|handling sensitivity|amod|END_ENTITY	Insulin sensitivity and the effects of insulin on renal sodium handling and pressor systems in essential hypertensive patients .
8671897	6	sodium	1049,1055	Insulin	1000,1007	sodium	insulin	MESH:D012964	3630	Chemical	Gene	excretion|compound|START_ENTITY induced|nmod|excretion END_ENTITY|acl|induced	RESULTS : Insulin induced similar decrements in fractional sodium excretion -LRB- N-NIDDM : 43 + / -5.9 and 57 + / -9.1 % , H-N IDDM : 48 + / -16.4 and 62 + / -12.5 % , low and high insulin dose respectively -RRB- .
9530121	0	sodium	66,72	Insulin	0,7	sodium	Insulin	MESH:D012964	3630	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|sensitivity sensitivity|compound|END_ENTITY	Insulin sensitivity is associated with blood pressure response to sodium in older hypertensives .
21448594	0	sodium	38,44	Interleukin-1b	0,14	sodium	Interleukin-1b	MESH:D012964	3553	Chemical	Gene	currents|compound|START_ENTITY inhibits|dobj|currents inhibits|nsubj|END_ENTITY	Interleukin-1b inhibits voltage-gated sodium currents in a time - and dose-dependent manner in cortical neurons .
1319570	0	sodium	23,29	Interleukin-2	0,13	sodium	Interleukin-2	MESH:D012964	3558	Chemical	Gene	currents|compound|START_ENTITY inhibits|dobj|currents inhibits|nsubj|END_ENTITY	Interleukin-2 inhibits sodium currents in human muscle cells .
20504903	0	sodium	36,42	Interleukin-6	0,13	sodium	Interleukin-6	MESH:D012964	16193(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY stimulates|dobj|channels stimulates|nsubj|END_ENTITY	Interleukin-6 stimulates epithelial sodium channels in mouse cortical collecting duct cells .
2200107	0	sodium	48,54	Interleukin_1_beta	0,18	sodium	Interleukin 1 beta	MESH:D012964	24494(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY increases|dobj|concentration increases|nsubj|END_ENTITY	Interleukin_1_beta increases the cytosolic free sodium concentration in isolated rat islets of Langerhans .
9154891	0	sodium	51,57	Keratinocyte_growth_factor	0,26	sodium	Keratinocyte growth factor	MESH:D012964	29348(Tax:10116)	Chemical	Gene	reabsorption|compound|START_ENTITY increases|dobj|reabsorption increases|nsubj|END_ENTITY	Keratinocyte_growth_factor increases transalveolar sodium reabsorption in normal and injured rat lungs .
16520744	0	sodium	52,58	LQT-3	39,44	sodium	LQT-3	MESH:D012964	6331	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Molecular basis of ranolazine block of LQT-3 mutant sodium channels : evidence for site of action .
17892895	0	sodium	117,123	LQT3	162,166	sodium	LQT3	MESH:D012964	6331	Chemical	Gene	current|compound|START_ENTITY current|nmod|END_ENTITY	Changes in action potentials and intracellular ionic homeostasis in a ventricular cell model related to a persistent sodium current in SCN5A mutations underlying LQT3 .
10363356	0	sodium	16,22	MAG	89,92	sodium	MAG	MESH:D012964	29409(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY Distribution|nmod|channels Distribution|appos|END_ENTITY	Distribution of sodium and potassium channels as well as myelin_associated_glycoprotein -LRB- MAG -RRB- during the early stages of Wallerian_degeneration .
6347437	0	sodium	108,114	N-acetyl-beta-D-glucosaminidase	28,59	sodium	N-acetyl-beta-D-glucosaminidase	MESH:D012964	10724	Chemical	Gene	value|nmod|START_ENTITY value|nmod|END_ENTITY	Diagnostic value of urinary N-acetyl-beta-D-glucosaminidase , its isoenzymes and the fractional excretion of sodium following renal transplantation .
15458921	0	sodium	7,13	NADPH_oxidase_1	84,99	sodium	NADPH oxidase 1	MESH:D012964	100735465	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	Ecabet sodium inhibits Helicobacter_pylori lipopolysaccharide-induced activation of NADPH_oxidase_1 or apoptosis of guinea_pig gastric mucosal cells .
17448995	0	sodium	47,53	NALCN	21,26	sodium	NALCN	MESH:D012964	338370(Tax:10090)	Chemical	Gene	contributes|dobj|START_ENTITY contributes|nsubj|END_ENTITY	The neuronal channel NALCN contributes resting sodium permeability and is required for normal respiratory rhythm .
11496061	0	sodium	18,24	NHE3	38,42	sodium	NHE3	MESH:D012964	6550	Chemical	Gene	Regulation|nmod|START_ENTITY transporters|nsubj|Regulation transporters|dobj|END_ENTITY	Regulation of the sodium transporters NHE3 , NKCC2 and NCC in the kidney .
20027604	0	sodium	118,124	NHE3	84,88	sodium	NHE3	MESH:D012964	6550	Chemical	Gene	defect|compound|START_ENTITY indicate|dobj|defect indicate|nsubj|function function|compound|END_ENTITY	Preserved Na -LRB- + -RRB- / H -LRB- + -RRB- _ exchanger_isoform_3 expression and localization , but decreased NHE3 function indicate regulatory sodium transport defect in ulcerative_colitis .
23405179	0	sodium	66,72	NHE3	91,95	sodium	NHE3	MESH:D012964	105243(Tax:10090)	Chemical	Gene	exchanger|compound|START_ENTITY exchanger|appos|END_ENTITY	Ezrin is required for the functional regulation of the epithelial sodium proton exchanger , NHE3 .
8772128	0	sodium	52,58	NHE3	12,16	sodium	NHE3	MESH:D012964	100009430(Tax:9986)	Chemical	Gene	absorption|compound|START_ENTITY exchanger|nmod|absorption Role|parataxis|exchanger Role|nmod|isoform isoform|compound|END_ENTITY	Role of the NHE3 isoform of the Na + / H + exchanger in sodium absorption by the rabbit gallbladder .
17460608	0	sodium	31,37	NKCC2	51,56	sodium	NKCC2	MESH:D012964	6557	Chemical	Gene	variation|nmod|START_ENTITY transporters|nsubj|variation transporters|dobj|END_ENTITY	Genetic variation in the renal sodium transporters NKCC2 , NCC , and ENaC in relation to the effects of loop diuretic drugs .
15286995	0	sodium	64,70	NaV1	86,90	sodium	NaV1	MESH:D012964	215690(Tax:10090)	Chemical	Gene	Scn8a|compound|START_ENTITY Scn8a|dep|.6 .6|compound|END_ENTITY	Floxed allele for conditional inactivation of the voltage-gated sodium channel Scn8a -LRB- NaV1 .6 -RRB- .
18650312	0	sodium	22,28	NaV1	15,19	sodium	NaV1	MESH:D012964	215690(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY Role|dep|channels Role|nmod|END_ENTITY	Role of axonal NaV1 .6 sodium channels in action potential initiation of CA1 pyramidal neurons .
20146699	0	sodium	53,59	NaV1	46,50	sodium	NaV1	MESH:D012964	89796	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Familial_pain_syndromes from mutations of the NaV1 .7 sodium channel .
22981330	0	sodium	21,27	NaV1	14,18	sodium	NaV1	MESH:D012964	685707(Tax:10116)	Chemical	Gene	currents|compound|START_ENTITY END_ENTITY|dobj|currents	Inhibition of NaV1 .6 sodium channel currents by a novel series of 1,4-disubstituted-triazole derivatives obtained via copper-catalyzed click chemistry .
22986623	0	sodium	92,98	NaV1	71,75	sodium	NaV1	MESH:D012964	215690(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dobj|channels	Resurgent-like currents in mouse vas deferens myocytes are mediated by NaV1 .6 voltage-gated sodium channels .
23942337	0	sodium	66,72	NaV1	81,85	sodium	NaV1	MESH:D012964	89796	Chemical	Gene	channel|compound|START_ENTITY modulation|nmod|channel basis|nmod|modulation END_ENTITY|nsubj|basis	Structural basis for the modulation of the neuronal voltage-gated sodium channel NaV1 .6 by calmodulin .
25686526	0	sodium	30,36	NaV1	23,27	sodium	NaV1	MESH:D012964	685707(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Local knockdown of the NaV1 .6 sodium channel reduces pain_behaviors , sensory neuron excitability , and sympathetic sprouting in rat models of neuropathic_pain .
21177381	0	sodium	54,60	Nalcn	91,96	sodium	Nalcn	MESH:D012964	338370(Tax:10090)	Chemical	Gene	concentrations|compound|START_ENTITY strains|nmod|concentrations analysis|nmod|strains identifies|nsubj|analysis identifies|dobj|channel channel|compound|END_ENTITY	Genetic analysis of mouse strains with variable serum sodium concentrations identifies the Nalcn sodium channel as a novel player in osmoregulation .
21177381	0	sodium	97,103	Nalcn	91,96	sodium	Nalcn	MESH:D012964	338370(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Genetic analysis of mouse strains with variable serum sodium concentrations identifies the Nalcn sodium channel as a novel player in osmoregulation .
12220575	0	sodium	44,50	Nav1	37,41	sodium	Nav1	MESH:D012964	89796	Chemical	Gene	channels|compound|START_ENTITY modulation|dep|channels modulation|nmod|END_ENTITY	Functional modulation of human brain Nav1 .3 sodium channels , expressed in mammalian cells , by auxiliary beta_1 , beta_2_and_beta_3 subunits .
15148385	0	sodium	99,105	Nav1	92,96	sodium	Nav1	MESH:D012964	89796	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Molecular changes in neurons in multiple_sclerosis : altered axonal expression of Nav1 .2 and Nav1 .6 sodium channels and Na + / Ca2 + _ exchanger .
15465873	0	sodium	41,47	Nav1	34,38	sodium	Nav1	MESH:D012964	89796	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Use-dependent potentiation of the Nav1 .6 sodium channel .
16078241	0	sodium	21,27	Nav1	14,18	sodium	Nav1	MESH:D012964	215690(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dobj|channels	Expression of Nav1 .6 sodium channels by Schwann cells at neuromuscular junctions : role in the motor endplate disease phenotype .
17273863	0	sodium	27,33	Nav1	51,55	sodium	Nav1	MESH:D012964	685707(Tax:10116)	Chemical	Gene	subunits|compound|START_ENTITY Downregulation|nmod|subunits END_ENTITY|nsubj|Downregulation	Downregulation of neuronal sodium channel subunits Nav1 .1 and Nav1 .6 in the sinoatrial node from volume-overloaded heart_failure rat .
17687633	0	sodium	30,36	Nav1	23,27	sodium	Nav1	MESH:D012964	100536287	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Knockdown of zebrafish Nav1 .6 sodium channel impairs embryonic locomotor activities .
18363861	0	sodium	65,71	Nav1	87,91	sodium	Nav1	MESH:D012964	215690(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY null|nmod|channel Scn8a|amod|null Scn8a|dep|.6 .6|compound|END_ENTITY	Exaggerated emotional behavior in mice heterozygous null for the sodium channel Scn8a -LRB- Nav1 .6 -RRB- .
20204400	0	sodium	47,53	Nav1	69,73	sodium	Nav1	MESH:D012964	89796	Chemical	Gene	current|compound|START_ENTITY current|nmod|channel channel|compound|END_ENTITY	Biophysical characterisation of the persistent sodium current of the Nav1 .6 neuronal sodium channel : a single-channel analysis .
20204400	0	sodium	85,91	Nav1	69,73	sodium	Nav1	MESH:D012964	89796	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Biophysical characterisation of the persistent sodium current of the Nav1 .6 neuronal sodium channel : a single-channel analysis .
20421839	0	sodium	35,41	Nav1	50,54	sodium	Nav1	MESH:D012964	685707(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY up-regulation|nmod|channel END_ENTITY|nsubj|up-regulation	The up-regulation of voltage-gated sodium channel Nav1 .6 expression following fluid percussion traumatic_brain_injury in rats .
20678086	0	sodium	74,80	Nav1	130,134	sodium	Nav1	MESH:D012964	685707(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY modulator|nmod|channels selectivity|nmod|modulator determination|nmod|selectivity determination|dep|clue clue|nmod|importance importance|nmod|END_ENTITY	Molecular determination of selectivity of the site 3 modulator -LRB- BmK_I -RRB- to sodium channels in the CNS : a clue to the importance of Nav1 .6 in BmK_I-induced neuronal_hyperexcitability .
21177993	0	sodium	64,70	Nav1	57,61	sodium	Nav1	MESH:D012964	685707(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Alterations of action potentials and the localization of Nav1 .6 sodium channels in spared axons after hemisection injury of the spinal cord in adult rats .
21439942	0	sodium	61,67	Nav1	40,44	sodium	Nav1	MESH:D012964	685707(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dobj|channels	Independent and joint modulation of rat Nav1 .6 voltage-gated sodium channels by coexpression with the auxiliary b1_and_b2 subunits .
22465659	0	sodium	75,81	Nav1	68,72	sodium	Nav1	MESH:D012964	685707(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dobj|channels	Differential state-dependent modification of inactivation-deficient Nav1 .6 sodium channels by the pyrethroid insecticides S-bioallethrin , tefluthrin and deltamethrin .
22623668	0	sodium	75,81	Nav1	68,72	sodium	Nav1	MESH:D012964	685707(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|nummod|.6 .6|compound|END_ENTITY	An ankyrinG-binding motif is necessary and sufficient for targeting Nav1 .6 sodium channels to axon initial segments and nodes of Ranvier .
22995823	0	sodium	68,74	Nav1	61,65	sodium	Nav1	MESH:D012964	89796	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	In silico docking reveals possible Riluzole binding sites on Nav1 .6 sodium channel : implications for amyotrophic_lateral_sclerosis therapy .
24404202	0	sodium	50,56	Nav1	29,33	sodium	Nav1	MESH:D012964	685707(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|dep|END_ENTITY	Functional expression of Rat Nav1 .6 voltage-gated sodium channels in HEK293 cells : modulation by the auxiliary b1 subunit .
26708501	0	sodium	66,72	Nav1	59,63	sodium	Nav1	MESH:D012964	685707(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Effects of the b1 auxiliary subunit on modification of Rat Nav1 .6 sodium channels expressed in HEK293 cells by the pyrethroid insecticides tefluthrin and deltamethrin .
27013268	0	sodium	40,46	Nav1	33,37	sodium	Nav1	MESH:D012964	685707(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dobj|channels	Functional reconstitution of rat Nav1 .6 sodium channels in vitro for studies of pyrethroid action .
11495939	0	sodium	30,36	Nerve_growth_factor	0,19	sodium	Nerve growth factor	MESH:D012964	18049(Tax:10090)	Chemical	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Nerve_growth_factor regulates sodium but not potassium channel currents in sympathetic B neurons of adult bullfrogs .
12039870	0	sodium	30,36	Nerve_growth_factor	0,19	sodium	Nerve growth factor	MESH:D012964	4803	Chemical	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Nerve_growth_factor increases sodium channel expression in pancreatic beta cells : implications for insulin secretion .
12181690	0	sodium	28,34	PN1	16,19	sodium	PN1	MESH:D012964	5270	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Accumulation of PN1 and PN3 sodium channels in painful human neuroma-evidence from immunocytochemistry .
9037087	0	sodium	55,61	PN1	18,21	sodium	PN1	MESH:D012964	29366(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|appos|channel	Identification of PN1 , a predominant voltage-dependent sodium channel expressed principally in peripheral neurons .
14527872	0	sodium	60,66	PN3	56,59	sodium	PN3	MESH:D012964	6336	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Stable expression and characterization of human PN1 and PN3 sodium channels .
27067528	0	sodium	37,43	PPAR	14,18	sodium	PPAR	MESH:D012964	5465	Chemical	Gene	homeostasis|compound|START_ENTITY link|nmod|homeostasis END_ENTITY|dep|link	Hypertension : PPAR : a link between sodium and glucose homeostasis .
7646525	0	sodium	44,50	Parathyroid_hormone	0,19	sodium	Parathyroid hormone	MESH:D012964	5741	Chemical	Gene	transport|compound|START_ENTITY stimulates|dobj|transport stimulates|nsubj|END_ENTITY	Parathyroid_hormone stimulates electrogenic sodium transport in A6 cells .
17556514	0	sodium	21,27	PpENA1	36,42	sodium	PpENA1	MESH:D012964	5923286(Tax:145481)	Chemical	Gene	ATPase|compound|START_ENTITY ATPase|appos|END_ENTITY	Exclusion of Na + via sodium ATPase -LRB- PpENA1 -RRB- ensures normal growth of Physcomitrella_patens under moderate salt stress .
17679042	0	sodium	125,131	Renin	62,67	sodium	Renin	MESH:D012964	5972	Chemical	Gene	intake|compound|START_ENTITY blockers|nmod|intake blockers|nmod|activity activity|compound|END_ENTITY	Effects of angiotensin receptor blockers on ambulatory plasma Renin activity in healthy , normal subjects during unrestricted sodium intake .
196509	0	sodium	84,90	Renin	0,5	sodium	Renin	MESH:D012964	403838(Tax:9615)	Chemical	Gene	effect|nmod|START_ENTITY release|dep|effect release|amod|END_ENTITY	Renin release and pressor response to renal arterial hypotension : effect of dietary sodium .
2646216	0	sodium	68,74	Renin	0,5	sodium	Renin	MESH:D012964	5972	Chemical	Gene	influence|nmod|START_ENTITY regulation|dep|influence regulation|compound|END_ENTITY	Renin regulation in type_II_diabetes_mellitus : influence of dietary sodium .
3555117	0	sodium	70,76	Renin	0,5	sodium	Renin	MESH:D012964	24715(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|effects effects|amod|END_ENTITY	Renin secretory effects of N6-cyclohexyladenosine : effects of dietary sodium .
7000394	0	sodium	66,72	Renin	0,5	sodium	Renin	MESH:D012964	5972	Chemical	Gene	excretion|nmod|START_ENTITY relation|nmod|excretion END_ENTITY|dep|relation	Renin and aldosterone in hypothyroidism : relation to excretion of sodium and potassium .
8104577	0	sodium	63,69	Renin	0,5	sodium	Renin	MESH:D012964	5972	Chemical	Gene	loading|compound|START_ENTITY END_ENTITY|nmod|loading	Renin suppressibility and blood pressure response during acute sodium loading in patients with essential hypertension .
8719773	0	sodium	53,59	Renin	0,5	sodium	Renin	MESH:D012964	24715(Tax:10116)	Chemical	Gene	restriction|compound|START_ENTITY effect|nmod|restriction expression|dep|effect expression|compound|END_ENTITY	Renin gene expression in the aging kidney : effect of sodium restriction .
8730435	0	sodium	23,29	Renin	0,5	sodium	Renin	MESH:D012964	24715(Tax:10116)	Chemical	Gene	excretion|compound|START_ENTITY immunochemistry|appos|excretion immunochemistry|compound|END_ENTITY	Renin immunochemistry , sodium excretion and relative heart weight in cyclosporine - or alimentary-induced magnesium_deficiency in rats .
10623608	0	sodium	46,52	SCN12A	81,87	sodium	SCN12A	MESH:D012964	11280	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Identification of a novel human voltage-gated sodium channel alpha subunit gene , SCN12A .
12566275	0	sodium	13,19	SCN1A	50,55	sodium	SCN1A	MESH:D012964	6323	Chemical	Gene	alpha|compound|START_ENTITY Mutations|nmod|alpha subunit|nsubj|Mutations subunit|dobj|type type|appos|END_ENTITY	Mutations of sodium channel alpha subunit type 1 -LRB- SCN1A -RRB- in intractable childhood epilepsies with frequent generalized tonic-clonic_seizures .
14672992	0	sodium	62,68	SCN1A	77,82	sodium	SCN1A	MESH:D012964	6323	Chemical	Gene	channel|compound|START_ENTITY Epilepsy-associated_dysfunction|nmod|channel END_ENTITY|nsubj|Epilepsy-associated_dysfunction	Epilepsy-associated_dysfunction in the voltage-gated neuronal sodium channel SCN1A .
16054936	0	sodium	39,45	SCN1A	54,59	sodium	SCN1A	MESH:D012964	6323	Chemical	Gene	channel|compound|START_ENTITY Mutation|nmod|channel END_ENTITY|nsubj|Mutation	Mutation in the neuronal voltage-gated sodium channel SCN1A in familial_hemiplegic_migraine .
16326807	0	sodium	28,34	SCN1A	44,49	sodium	SCN1A	MESH:D012964	6323	Chemical	Gene	mutation|compound|START_ENTITY mutation|appos|END_ENTITY	Identification of an Nav1 .1 sodium channel -LRB- SCN1A -RRB- loss-of-function mutation associated with familial_simple_febrile_seizures .
16525050	0	sodium	28,34	SCN1A	43,48	sodium	SCN1A	MESH:D012964	6323	Chemical	Gene	channel|compound|START_ENTITY mutation|nmod|channel END_ENTITY|nsubj|mutation	An epilepsy mutation in the sodium channel SCN1A that decreases channel excitability .
17054697	1	sodium	113,119	SCN1A	134,139	sodium	SCN1A	MESH:D012964	6323	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	PURPOSE : Mutations of the alpha1 subunit sodium channel gene -LRB- SCN1A -RRB- cause severe_myoclonic_epilepsy_of_infancy -LRB- SMEI -RRB- .
19402159	0	sodium	45,51	SCN1A	38,43	sodium	SCN1A	MESH:D012964	6323	Chemical	Gene	causes|compound|START_ENTITY GEFS|dep|causes GEFS|dep|folding folding|dep|Nav1 Nav1|dep|.1 .1|appos|END_ENTITY	A rescuable folding defective Nav1 .1 -LRB- SCN1A -RRB- sodium channel mutant causes GEFS + : common mechanism in Nav1 .1 related epilepsies ?
20100831	0	sodium	44,50	SCN1A	24,29	sodium	SCN1A	MESH:D012964	20265(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Altered function of the SCN1A voltage-gated sodium channel leads to gamma-aminobutyric_acid-ergic -LRB- GABAergic -RRB- interneuron abnormalities .
20477842	0	sodium	59,65	SCN1A	79,84	sodium	SCN1A	MESH:D012964	6323	Chemical	Gene	gene|compound|START_ENTITY polymorphisms|nmod|gene association|nmod|polymorphisms detect|dobj|association Failure|acl|detect END_ENTITY|nsubj|Failure	Failure to detect association between polymorphisms of the sodium channel gene SCN1A and febrile_seizures in Chinese patients with epilepsy .
20519669	0	sodium	68,74	SCN1A	88,93	sodium	SCN1A	MESH:D012964	6323	Chemical	Gene	mutation|compound|START_ENTITY mutation|compound|END_ENTITY	Benign convulsions with mild gastroenteritis : is it associated with sodium channel gene SCN1A mutation ?
22150645	0	sodium	61,67	SCN1A	54,59	sodium	SCN1A	MESH:D012964	6323	Chemical	Gene	channel|aux|START_ENTITY channel|nsubj|haploinsufficiency haploinsufficiency|nmod|1.1 1.1|appos|END_ENTITY	Pure haploinsufficiency for Dravet_syndrome Na -LRB- V -RRB- 1.1 -LRB- SCN1A -RRB- sodium channel truncating mutations .
23494229	0	sodium	53,59	SCN1A	47,52	sodium	SCN1A	MESH:D012964	20265(Tax:10090)	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Effects of an epilepsy-causing mutation in the SCN1A sodium channel gene on cocaine-induced seizure susceptibility in mice .
24337656	0	sodium	69,75	SCN1A	90,95	sodium	SCN1A	MESH:D012964	6323	Chemical	Gene	polymorphisms|nmod|START_ENTITY study|nmod|polymorphisms channel|nsubj|study channel|xcomp|genes genes|nummod|END_ENTITY	Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A , SCN2A , SCN3A , SCN1B , and SCN2B and epilepsy .
8062593	0	sodium	39,45	SCN1A	60,65	sodium	SCN1A	MESH:D012964	6323	Chemical	Gene	gene|compound|START_ENTITY Localization|nmod|gene Localization|appos|END_ENTITY	Localization of a putative human brain sodium channel gene -LRB- SCN1A -RRB- to chromosome band 2q24 .
24337656	0	sodium	69,75	SCN1B	111,116	sodium	SCN1B	MESH:D012964	6324	Chemical	Gene	polymorphisms|nmod|START_ENTITY study|nmod|polymorphisms channel|nsubj|study channel|xcomp|genes genes|nummod|END_ENTITY	Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A , SCN2A , SCN3A , SCN1B , and SCN2B and epilepsy .
11738931	0	sodium	18,24	SCN2A	38,43	sodium	SCN2A	MESH:D012964	6326	Chemical	Gene	channel|nsubj|START_ENTITY channel|dobj|END_ENTITY	The voltage-gated sodium channel gene SCN2A and idiopathic_generalized_epilepsy .
24337656	0	sodium	69,75	SCN2A	97,102	sodium	SCN2A	MESH:D012964	6326	Chemical	Gene	polymorphisms|nmod|START_ENTITY study|nmod|polymorphisms channel|nsubj|study channel|xcomp|genes genes|nummod|END_ENTITY	Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A , SCN2A , SCN3A , SCN1B , and SCN2B and epilepsy .
2571571	0	sodium	30,36	SCN2A	51,56	sodium	SCN2A	MESH:D012964	6326	Chemical	Gene	gene|compound|START_ENTITY Localization|nmod|gene Localization|appos|END_ENTITY	Localization of a human brain sodium channel gene -LRB- SCN2A -RRB- to chromosome 2 .
18242854	0	sodium	12,18	SCN3A	27,32	sodium	SCN3A	MESH:D012964	6328	Chemical	Gene	channel|compound|START_ENTITY Mutation|nmod|channel END_ENTITY|nsubj|Mutation	Mutation of sodium channel SCN3A in a patient with cryptogenic pediatric partial_epilepsy .
24337656	0	sodium	69,75	SCN3A	104,109	sodium	SCN3A	MESH:D012964	6328	Chemical	Gene	polymorphisms|nmod|START_ENTITY study|nmod|polymorphisms channel|nsubj|study channel|xcomp|genes genes|nummod|END_ENTITY	Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A , SCN2A , SCN3A , SCN1B , and SCN2B and epilepsy .
10369308	0	sodium	59,65	SCN4A	89,94	sodium	SCN4A	MESH:D012964	6329	Chemical	Gene	alpha-subunit|compound|START_ENTITY alpha-subunit|appos|END_ENTITY	A novel mutation in the gene for the adult skeletal muscle sodium channel alpha-subunit -LRB- SCN4A -RRB- that causes paramyotonia congenita_of_von_Eulenburg .
12766226	0	sodium	52,58	SCN4A	46,51	sodium	SCN4A	MESH:D012964	6329	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Myasthenic_syndrome caused by mutation of the SCN4A sodium channel .
18203179	0	sodium	91,97	SCN4A	107,112	sodium	SCN4A	MESH:D012964	6329	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Severe_neonatal_non-dystrophic_myotonia secondary to a novel mutation of the voltage-gated sodium channel -LRB- SCN4A -RRB- gene .
21665479	0	sodium	119,125	SCN4A	140,145	sodium	SCN4A	MESH:D012964	6329	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Severe phenotypes of paralysis periodica paramyotonia are associated with the Met1592Val mutation in the voltage-gated sodium channel gene -LRB- SCN4A -RRB- in a Chinese family .
22617007	0	sodium	2,8	SCN4A	41,46	sodium	SCN4A	MESH:D012964	6329	Chemical	Gene	myotonia|compound|START_ENTITY myotonia|amod|due due|nmod|mutation mutation|compound|END_ENTITY	A sodium channel myotonia due to a novel SCN4A mutation accompanied by acquired autoimmune_myasthenia_gravis .
25735906	0	sodium	36,42	SCN4A	96,101	sodium	SCN4A	MESH:D012964	6329	Chemical	Gene	myotonia|compound|START_ENTITY onset|nmod|myotonia phenotype|dobj|onset phenotype|nmod|mutation mutation|nmod|gene gene|compound|END_ENTITY	New phenotype and neonatal onset of sodium channel myotonia in a child with a novel mutation of SCN4A gene .
26036855	0	sodium	106,112	SCN4A	0,5	sodium	SCN4A	MESH:D012964	6329	Chemical	Gene	channelopathies|compound|START_ENTITY overlap|nmod|channelopathies variants|dep|overlap variants|nummod|END_ENTITY	SCN4A variants and Brugada_syndrome : phenotypic and genotypic overlap between cardiac and skeletal muscle sodium channelopathies .
8044656	0	sodium	24,30	SCN4A	45,50	sodium	SCN4A	MESH:D012964	6329	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mutations in the muscle sodium channel gene -LRB- SCN4A -RRB- in 13 French families with hyperkalemic periodic paralysis and paramyotonia_congenita : phenotype to genotype correlations and demonstration of the predominance of two mutations .
9508059	0	sodium	99,105	SCN4A	115,120	sodium	SCN4A	MESH:D012964	6329	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Linkage of malignant hyperthermia and hyperkalemic periodic paralysis to the adult skeletal muscle sodium channel -LRB- SCN4A -RRB- gene in a large pedigree .
9703181	0	sodium	113,119	SCN4A	134,139	sodium	SCN4A	MESH:D012964	6329	Chemical	Gene	channel|compound|START_ENTITY mutation|nmod|channel due|nmod|mutation gene|amod|due gene|appos|END_ENTITY	Salbutamol treatment in a patient with hyperkalaemic periodic paralysis due to a mutation in the skeletal muscle sodium channel gene -LRB- SCN4A -RRB- .
10598960	0	sodium	72,78	SCN5A	66,71	sodium	SCN5A	MESH:D012964	6331	Chemical	Gene	mutation|compound|START_ENTITY mutation|compound|END_ENTITY	Beat-to-Beat repolarization variability in LQTS patients with the SCN5A sodium channel gene mutation .
10690282	0	sodium	41,47	SCN5A	6,11	sodium	SCN5A	MESH:D012964	6331	Chemical	Gene	kinetics|compound|START_ENTITY alter|dobj|kinetics alter|nsubj|mutations mutations|compound|END_ENTITY	Human SCN5A gene mutations alter cardiac sodium channel kinetics and are associated with the Brugada_syndrome .
12193783	0	sodium	17,23	SCN5A	11,16	sodium	SCN5A	MESH:D012964	6331	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Variant of SCN5A sodium channel implicated in risk of cardiac_arrhythmia .
14523039	0	sodium	76,82	SCN5A	97,102	sodium	SCN5A	MESH:D012964	6331	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Congenital_sick_sinus_syndrome caused by recessive mutations in the cardiac sodium channel gene -LRB- SCN5A -RRB- .
14654377	0	sodium	96,102	SCN5A	20,25	sodium	SCN5A	MESH:D012964	6331	Chemical	Gene	inactivation|compound|START_ENTITY residue|nmod|inactivation role|nmod|residue mutation|dep|role mutation|nmod|END_ENTITY	A novel mutation in SCN5A , delQKP 1507-1509 , causing long_QT_syndrome : role of Q1507 residue in sodium channel inactivation .
14732202	0	sodium	58,64	SCN5A	74,79	sodium	SCN5A	MESH:D012964	6331	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Cloning and initial characterization of the human cardiac sodium channel -LRB- SCN5A -RRB- promoter .
14753626	0	sodium	45,51	SCN5A	66,71	sodium	SCN5A	MESH:D012964	6331	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The implications of genetic mutations in the sodium channel gene -LRB- SCN5A -RRB- .
15338453	0	sodium	32,38	SCN5A	52,57	sodium	SCN5A	MESH:D012964	6331	Chemical	Gene	gene|compound|START_ENTITY analysis|nmod|gene END_ENTITY|nsubj|analysis	Genetic analysis of the cardiac sodium channel gene SCN5A in Koreans with Brugada_syndrome .
15863661	0	sodium	78,84	SCN5A	48,53	sodium	SCN5A	MESH:D012964	6331	Chemical	Gene	channelopathy|compound|START_ENTITY associates|nmod|channelopathy associates|nummod|END_ENTITY	Unconventional intronic splice site mutation in SCN5A associates with cardiac sodium channelopathy .
16453024	0	sodium	17,23	SCN5A	98,103	sodium	SCN5A	MESH:D012964	6331	Chemical	Gene	variant|compound|START_ENTITY associated|nsubj|variant associated|nmod|sudden_infant_death sudden_infant_death|nmod|Americans Americans|appos|S1103Y S1103Y|compound|END_ENTITY	A common cardiac sodium channel variant associated with sudden_infant_death in African Americans , SCN5A S1103Y .
17331104	0	sodium	58,64	SCN5A	9,14	sodium	SCN5A	MESH:D012964	6331	Chemical	Gene	channels|compound|START_ENTITY responsiveness|nmod|channels alters|dobj|responsiveness alters|nsubj|variant variant|compound|END_ENTITY	A common SCN5A variant alters the responsiveness of human sodium channels to class I antiarrhythmic agents .
17892895	0	sodium	117,123	SCN5A	135,140	sodium	SCN5A	MESH:D012964	100723340	Chemical	Gene	current|compound|START_ENTITY current|nmod|LQT3 LQT3|compound|END_ENTITY	Changes in action potentials and intracellular ionic homeostasis in a ventricular cell model related to a persistent sodium current in SCN5A mutations underlying LQT3 .
18436145	0	sodium	8,14	SCN5A	61,66	sodium	SCN5A	MESH:D012964	6331	Chemical	Gene	channel|compound|START_ENTITY overlap|nsubj|channel overlap|dobj|syndromes syndromes|dep|faces faces|nmod|mutations mutations|nummod|END_ENTITY	Cardiac sodium channel overlap syndromes : different faces of SCN5A mutations .
19251209	0	sodium	105,111	SCN5A	8,13	sodium	SCN5A	MESH:D012964	6331	Chemical	Gene	channelopathies|compound|START_ENTITY slowing|nmod|channelopathies conduction|acl|slowing severity|nmod|conduction determines|dobj|severity determines|nsubj|Type Type|nmod|mutation mutation|compound|END_ENTITY	Type of SCN5A mutation determines clinical severity and degree of conduction slowing in loss-of-function sodium channelopathies .
19406494	0	sodium	6,12	SCN5A	21,26	sodium	SCN5A	MESH:D012964	6331	Chemical	Gene	mutations|compound|START_ENTITY mutations|compound|END_ENTITY	Novel sodium channel SCN5A mutations in Brugada_syndrome patients from Greece .
21167004	0	sodium	69,75	SCN5A	0,5	sodium	SCN5A	MESH:D012964	6331	Chemical	Gene	current|compound|START_ENTITY decrease|dobj|current decrease|nsubj|variants variants|nummod|END_ENTITY	SCN5A rare variants in familial dilated_cardiomyopathy decrease peak sodium current depending on the common polymorphism H558R and common splice variant Q1077del .
21840964	0	sodium	31,37	SCN5A	100,105	sodium	SCN5A	MESH:D012964	6331	Chemical	Gene	channel|compound|START_ENTITY polymorphic|nsubj|channel using|xcomp|polymorphic strategy|acl|using fragments|nsubj|strategy fragments|xcomp|rescue rescue|dobj|mutations mutations|compound|END_ENTITY	A novel strategy using cardiac sodium channel polymorphic fragments to rescue trafficking-deficient SCN5A mutations .
23541953	0	sodium	27,33	SCN5A	90,95	sodium	SCN5A	MESH:D012964	6331	Chemical	Gene	current|compound|START_ENTITY suppresses|dobj|current suppresses|advcl|inhibiting inhibiting|dobj|S-nitrosylation S-nitrosylation|nmod|END_ENTITY	Caveolin-3 suppresses late sodium current by inhibiting nNOS-dependent S-nitrosylation of SCN5A .
23558814	0	sodium	107,113	SCN5A	122,127	sodium	SCN5A	MESH:D012964	6331	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Congenital long_QT_syndrome of particularly malignant course connected with so far unknown mutation in the sodium channel SCN5A gene .
23818691	0	sodium	8,14	SCN5A	45,50	sodium	SCN5A	MESH:D012964	6331	Chemical	Gene	START_ENTITY|acl|associated associated|nmod|mutations mutations|nummod|END_ENTITY	Cardiac sodium channelopathy associated with SCN5A mutations : electrophysiological , molecular and genetic aspects .
26031372	0	sodium	53,59	SCN5A	95,100	sodium	SCN5A	MESH:D012964	6331	Chemical	Gene	channels|compound|START_ENTITY stability|nmod|channels fast-inactivated|dobj|stability fast-inactivated|nmod|mutation mutation|compound|END_ENTITY	Enhanced fast-inactivated state stability of cardiac sodium channels by a novel voltage sensor SCN5A mutation , R1632C , as a cause of atypical Brugada_syndrome .
26084969	0	sodium	97,103	SCN5A	112,117	sodium	SCN5A	MESH:D012964	6331	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Purkinje-related ventricular_fibrillation associated with a homozygous H558R polymorphism in the sodium channel SCN5A gene .
26209011	0	sodium	43,49	SCN5A	63,68	sodium	SCN5A	MESH:D012964	6331	Chemical	Gene	gene|compound|START_ENTITY regulation|nmod|gene END_ENTITY|nsubj|regulation	Post-transcriptional regulation of cardiac sodium channel gene SCN5A expression and function by miR-192-5p .
16236810	0	sodium	52,58	SCN8A	67,72	sodium	SCN8A	MESH:D012964	6334	Chemical	Gene	channel|compound|START_ENTITY mutation|nmod|channel Heterozygosity|nmod|mutation END_ENTITY|nsubj|Heterozygosity	Heterozygosity for a protein truncation mutation of sodium channel SCN8A in a patient with cerebellar_atrophy , ataxia , and mental_retardation .
22474336	0	sodium	29,35	SCN8A	52,57	sodium	SCN8A	MESH:D012964	20273(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY Interaction|nmod|channel Nav1|nsubj|Interaction Nav1|dobj|.6 .6|appos|END_ENTITY	Interaction of voltage-gated sodium channel Nav1 .6 -LRB- SCN8A -RRB- with microtubule-associated protein Map1b .
14985375	0	sodium	31,37	SCN9A	13,18	sodium	SCN9A	MESH:D012964	6335	Chemical	Gene	channel|compound|START_ENTITY encoding|dobj|channel Mutations|acl|encoding Mutations|nmod|END_ENTITY	Mutations in SCN9A , encoding a sodium channel alpha subunit , in patients with primary_erythermalgia .
15178348	0	sodium	14,20	SCN9A	93,98	sodium	SCN9A	MESH:D012964	6335	Chemical	Gene	channel|compound|START_ENTITY channel|dep|involvement involvement|nmod|END_ENTITY	Voltage-gated sodium channel expressed in cultured human smooth muscle cells : involvement of SCN9A .
15955112	0	sodium	88,94	SCN9A	0,5	sodium	SCN9A	MESH:D012964	6335	Chemical	Gene	channels|compound|START_ENTITY neuropathic_disorder|nmod|channels define|nmod|neuropathic_disorder define|nsubj|mutations mutations|compound|END_ENTITY	SCN9A mutations define primary_erythermalgia as a neuropathic_disorder of voltage gated sodium channels .
18249135	0	sodium	87,93	SCN9A	108,113	sodium	SCN9A	MESH:D012964	6335	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Identification and characterization of the promoter region of the Nav1 .7 voltage-gated sodium channel gene -LRB- SCN9A -RRB- .
18347287	0	sodium	27,33	SCN9A	63,68	sodium	SCN9A	MESH:D012964	6335	Chemical	Gene	channelopathy|compound|START_ENTITY Primary_erythermalgia|nmod|channelopathy Primary_erythermalgia|dep|screening screening|nmod|mutations mutations|nummod|END_ENTITY	Primary_erythermalgia as a sodium channelopathy : screening for SCN9A mutations : exclusion of a causal role of SCN10A and SCN11A .
19549232	0	sodium	176,182	SCN9A	139,144	sodium	SCN9A	MESH:D012964	6335	Chemical	Gene	channel|compound|START_ENTITY encoding|dobj|channel identified|xcomp|encoding identified|xcomp|have have|dobj|mutation mutation|nmod|gene gene|compound|END_ENTITY	Treatment with carbamazepine and gabapentin of a patient with primary_erythermalgia -LRB- erythromelalgia -RRB- identified to have a mutation in the SCN9A gene , encoding a voltage-gated sodium channel .
20074229	0	sodium	41,47	SCN9A	76,81	sodium	SCN9A	MESH:D012964	6335	Chemical	Gene	alpha1|compound|START_ENTITY mutations|nmod|alpha1 subunit|nsubj|mutations subunit|dobj|END_ENTITY	No mutations in the voltage-gated NaV1 .7 sodium channel alpha1 subunit gene SCN9A in familial_complex_regional_pain_syndrome .
21094958	0	sodium	77,83	SCN9A	92,97	sodium	SCN9A	MESH:D012964	6335	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Chronic non-paroxysmal neuropathic_pain - Novel phenotype of mutation in the sodium channel SCN9A gene .
22170168	0	sodium	67,73	SCN9A	108,113	sodium	SCN9A	MESH:D012964	6335	Chemical	Gene	START_ENTITY|nmod|mutations mutations|compound|END_ENTITY	Primary erythromelalgia in a 12-year-old boy : positive response to sodium channel blockers despite negative SCN9A mutations .
22348792	0	sodium	41,47	SCN9A	2,7	sodium	SCN9A	MESH:D012964	6335	Chemical	Gene	polymorphism|compound|START_ENTITY root|dobj|polymorphism root|nsubj|dorsal dorsal|compound|END_ENTITY	A SCN9A gene-encoded dorsal root ganglia sodium channel polymorphism associated with severe fibromyalgia .
23895530	0	sodium	12,18	SCN9A	27,32	sodium	SCN9A	MESH:D012964	6335	Chemical	Gene	channel|compound|START_ENTITY Role|nmod|channel END_ENTITY|nsubj|Role	Role of the sodium channel SCN9A in genetic_epilepsy with febrile_seizures plus and Dravet_syndrome .
10760055	0	sodium	43,49	SGK	8,11	sodium	SGK	MESH:D012964	29517(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY Role|nmod|transport Role|nmod|END_ENTITY	Role of SGK in mineralocorticoid-regulated sodium transport .
22691875	0	sodium	24,30	SGK	0,3	sodium	SGK	MESH:D012964	6446	Chemical	Gene	transport|compound|START_ENTITY regulation|nmod|transport regulation|compound|END_ENTITY	SGK regulation of renal sodium transport .
23152905	0	sodium	107,113	SGK-1	134,139	sodium	SGK-1	MESH:D012964	6446	Chemical	Gene	channels|compound|START_ENTITY channels|nmod|END_ENTITY	The plant-derived glucocorticoid_receptor agonist Endiandrin_A acts as co-stimulator of colonic epithelial sodium channels -LRB- ENaC -RRB- via SGK-1 and MAPKs .
11551807	0	sodium	38,44	SGK1	12,16	sodium	SGK1	MESH:D012964	6446	Chemical	Gene	transport|compound|START_ENTITY role|nmod|transport role|nmod|END_ENTITY	The role of SGK1 in hormone-regulated sodium transport .
16749855	0	sodium	7,13	SLC10A2	53,60	sodium	SLC10A2	MESH:D012964	6555	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|ASBT ASBT|dep|END_ENTITY	Apical sodium dependent bile_acid transporter -LRB- ASBT , SLC10A2 -RRB- : a potential prodrug target .
24310820	0	sodium	56,62	SLC12A3	34,41	sodium	SLC12A3	MESH:D012964	6559	Chemical	Gene	roles|nmod|START_ENTITY END_ENTITY|dep|roles	The sodium_chloride cotransporter SLC12A3 : new roles in sodium , potassium , and blood pressure regulation .
11972032	0	sodium	87,93	Scn5a	107,112	sodium	Scn5a	MESH:D012964	20271(Tax:10090)	Chemical	Gene	disruption|nmod|START_ENTITY conduction|nmod|disruption channel|nsubj|conduction channel|dobj|END_ENTITY	Slowed conduction and ventricular_tachycardia after targeted disruption of the cardiac sodium channel gene Scn5a .
15932895	0	sodium	75,81	Scn5a	95,100	sodium	Scn5a	MESH:D012964	20271(Tax:10090)	Chemical	Gene	disruption|nmod|START_ENTITY Sinus_node_dysfunction|nmod|disruption channel|nsubj|Sinus_node_dysfunction channel|dobj|END_ENTITY	Sinus_node_dysfunction following targeted disruption of the murine cardiac sodium channel gene Scn5a .
15901786	0	sodium	72,78	Scn8a	95,100	sodium	Scn8a	MESH:D012964	20273(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Physiological maturation of photoreceptors depends on the voltage-gated sodium channel NaV1 .6 -LRB- Scn8a -RRB- .
18363861	0	sodium	65,71	Scn8a	80,85	sodium	Scn8a	MESH:D012964	20273(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY null|nmod|channel END_ENTITY|amod|null	Exaggerated emotional behavior in mice heterozygous null for the sodium channel Scn8a -LRB- Nav1 .6 -RRB- .
18601978	0	sodium	31,37	Scn8a	129,134	sodium	Scn8a	MESH:D012964	20273(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY Na|dep|channels expression|nmod|Na heterozygous|nsubj|expression heterozygous|nmod|mutation mutation|nmod|END_ENTITY	Reduced expression of Na -LRB- v -RRB- 1.6 sodium channels and compensation by Na -LRB- v -RRB- 1.2 channels in mice heterozygous for a null mutation in Scn8a .
20353942	0	sodium	39,45	Scn8a	19,24	sodium	Scn8a	MESH:D012964	6334	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Dysfunction of the Scn8a voltage-gated sodium channel alters sleep architecture , reduces diurnal corticosterone levels , and enhances spatial memory .
7670495	0	sodium	18,24	Scn8a	39,44	sodium	Scn8a	MESH:D012964	20273(Tax:10090)	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mutation of a new sodium channel gene , Scn8a , in the mouse mutant ` motor endplate disease ' .
8654536	0	sodium	27,33	Scn8a	43,48	sodium	Scn8a	MESH:D012964	20273(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	The neuronal voltage-gated sodium channel , Scn8a , is essential for postnatal maturation of spinal , but not oculomotor , motor units .
9651206	0	sodium	93,99	Scn8a	19,24	sodium	Scn8a	MESH:D012964	20273(Tax:10090)	Chemical	Gene	density|compound|START_ENTITY increase|nmod|density contributor|nmod|increase contributor|nsubj|END_ENTITY	The sodium channel Scn8a is the major contributor to the postnatal developmental increase of sodium current density in spinal motoneurons .
9698304	0	sodium	39,45	Scn8a	33,38	sodium	Scn8a	MESH:D012964	20273(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Functional analysis of the mouse Scn8a sodium channel .
11065344	0	sodium	6,12	Scnn1	0,5	sodium	Scnn1	MESH:D012964	20276(Tax:10090)	Chemical	Gene	family|compound|START_ENTITY family|amod|END_ENTITY	Scnn1 sodium channel gene family in genetically engineered mice .
7836935	0	sodium	61,67	SkM1	56,60	sodium	SkM1	MESH:D012964	25722(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Voltage-dependent regulation of modal gating in the rat SkM1 sodium channel expressed in Xenopus oocytes .
9607932	0	sodium	71,77	SkM1	66,70	sodium	SkM1	MESH:D012964	25722(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Inactivation and secondary structure in the D4/S4 -5 region of the SkM1 sodium channel .
8968581	0	sodium	55,61	Skm1	50,54	sodium	Skm1	MESH:D012964	25722(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Interaction between fast and slow inactivation in Skm1 sodium channels .
6102949	0	sodium	24,30	Somatostatin	0,12	sodium	Somatostatin	MESH:D012964	100353697(Tax:9986)	Chemical	Gene	absorption|compound|START_ENTITY stimulates|dobj|absorption stimulates|nsubj|END_ENTITY	Somatostatin stimulates sodium and chloride absorption in the rabbit ileum .
1376357	0	sodium	21,27	Substance_P	0,11	sodium	Substance P	MESH:D012964	6863	Chemical	Gene	secretion|compound|START_ENTITY produces|dobj|secretion produces|nsubj|END_ENTITY	Substance_P produces sodium and bicarbonate secretion in porcine jejunal mucosa through an action on enteric neurons .
24573382	0	sodium	39,45	TNF-a	84,89	sodium	TNF-a	MESH:D012964	21926(Tax:10090)	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|effects effects|nmod|END_ENTITY	Rubbing salt into wounded endothelium : sodium potentiates proatherogenic effects of TNF-a under non-uniform shear stress .
18230619	0	sodium	115,121	TRPV1	164,169	sodium	TRPV1	MESH:D012964	7442	Chemical	Gene	START_ENTITY|nmod|sites sites|nmod|END_ENTITY	Novel gating and sensitizing mechanism of capsaicin_receptor -LRB- TRPV1 -RRB- : tonic inhibitory regulation of extracellular sodium through the external protonation sites on TRPV1 .
25866303	0	sodium	34,40	TRPV1	96,101	sodium	TRPV1	MESH:D012964	83810(Tax:10116)	Chemical	Gene	absorption|compound|START_ENTITY absorption|nmod|END_ENTITY	-LSB- 6 -RSB- - gingerol induces electrogenic sodium absorption in the rat colon via the capsaicin receptor TRPV1 .
23874427	0	sodium	97,103	TipE	24,28	sodium	TipE	MESH:D012964	38504(Tax:7227)	Chemical	Gene	channels|compound|START_ENTITY effects|nmod|channels effects|nmod|END_ENTITY	Differential effects of TipE and a TipE-homologous protein on modulation of gating properties of sodium channels from Drosophila_melanogaster .
8430772	0	sodium	37,43	Tyrosine_kinase	0,15	sodium	Tyrosine kinase	MESH:D012964	7294	Chemical	Gene	transport|compound|START_ENTITY regulates|dobj|transport regulates|nsubj|END_ENTITY	Tyrosine_kinase regulates epithelial sodium transport in A6 cells .
10516282	0	sodium	23,29	Vasopressin	0,11	sodium	Vasopressin	MESH:D012964	551	Chemical	Gene	transport|compound|START_ENTITY stimulates|dobj|transport stimulates|nsubj|END_ENTITY	Vasopressin stimulates sodium transport in A6 cells via a phosphatidylinositide_3-kinase-dependent pathway .
1646297	0	sodium	53,59	Vasopressin	0,11	sodium	Vasopressin	MESH:D012964	551	Chemical	Gene	current|compound|START_ENTITY generates|dobj|current generates|nsubj|END_ENTITY	Vasopressin generates a persistent voltage-dependent sodium current in a mammalian motoneuron .
18345422	0	sodium	42,48	Vasopressin	0,11	sodium	Vasopressin	MESH:D012964	551	Chemical	Gene	balance|compound|START_ENTITY levels|nmod|balance levels|amod|END_ENTITY	Vasopressin serum levels and disorders of sodium and water balance in patients with severe_brain_injury .
20736986	0	sodium	32,38	Vasopressin	0,11	sodium	Vasopressin	MESH:D012964	551	Chemical	Gene	excretion|compound|START_ENTITY regulation|nmod|excretion regulation|compound|END_ENTITY	Vasopressin regulation of renal sodium excretion .
3950526	0	sodium	86,92	Vasopressin	0,11	sodium	Vasopressin	MESH:D012964	551	Chemical	Gene	diets|compound|START_ENTITY secretion|nmod|diets secretion|nsubj|END_ENTITY	Vasopressin secretion in normotensive black and white men and women on normal and low sodium diets .
6286278	0	sodium	38,44	Vasopressin	0,11	sodium	Vasopressin	MESH:D012964	551	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|resistance resistance|compound|END_ENTITY	Vasopressin resistance induced by low sodium and high mannitol in toad bladder .
7686902	0	sodium	32,38	Vasopressin	0,11	sodium	Vasopressin	MESH:D012964	551	Chemical	Gene	concentration|compound|START_ENTITY increases|dobj|concentration increases|nsubj|END_ENTITY	Vasopressin increases cytosolic sodium concentration in hepatocytes and activates calcium influx through cation-selective channels .
9071954	0	sodium	84,90	Vasopressin	0,11	sodium	Vasopressin	MESH:D012964	551	Chemical	Gene	restriction|compound|START_ENTITY effects|nmod|restriction levels|dep|effects levels|compound|END_ENTITY	Vasopressin and oxytocin levels during normal pregnancy : effects of chronic dietary sodium restriction .
17341566	0	sodium	12,18	adiponectin	73,84	sodium	adiponectin	MESH:D012964	9370	Chemical	Gene	START_ENTITY|dobj|concentrations concentrations|compound|END_ENTITY	Low dietary sodium and exogenous angiotensin_II infusion decrease plasma adiponectin concentrations in healthy men .
18252244	0	sodium	179,185	alpha-subunit	67,80	sodium	alpha-subunit	MESH:D012964	34792(Tax:7227)	Chemical	Gene	channels|compound|START_ENTITY expressed|nsubj|channels fly|ccomp|expressed reduce|ccomp|fly reduce|nsubj|mutations mutations|acl|identified identified|nmod|gene gene|compound|END_ENTITY	Three mutations identified in the voltage-sensitive sodium channel alpha-subunit gene of permethrin-resistant human head_lice reduce the permethrin sensitivity of house fly Vssc1 sodium channels expressed in Xenopus oocytes .
18252244	0	sodium	52,58	alpha-subunit	67,80	sodium	alpha-subunit	MESH:D012964	34792(Tax:7227)	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Three mutations identified in the voltage-sensitive sodium channel alpha-subunit gene of permethrin-resistant human head_lice reduce the permethrin sensitivity of house fly Vssc1 sodium channels expressed in Xenopus oocytes .
17471453	0	sodium	26,32	alpha1	4,10	sodium	alpha1	MESH:D012964	146	Chemical	Gene	pump|compound|START_ENTITY subunit|nmod|pump subunit|amod|END_ENTITY	The alpha1 subunit of the sodium pump could represent a novel target to combat non-small_cell_lung_cancers .
1851181	0	sodium	151,157	angiotensin-II	120,134	sodium	angiotensin-II	MESH:D012964	183	Chemical	Gene	depletion|compound|START_ENTITY END_ENTITY|nmod|depletion	Lack of enhanced responsiveness of plasma 18-hydroxycorticosterone and aldosterone to adrenocorticotropin as well as to angiotensin-II during moderate sodium depletion in type II diabetic subjects with normoreninemia .
15175418	0	sodium	4,10	angiotensin-converting_enzyme	44,73	sodium	angiotensin-converting enzyme	MESH:D012964	24310(Tax:10116)	Chemical	Gene	modifies|nsubj|START_ENTITY modifies|dobj|effects effects|nmod|therapy therapy|amod|END_ENTITY	Low sodium modifies the vascular effects of angiotensin-converting_enzyme inhibitor therapy in healthy rats .
23398920	0	sodium	123,129	angiotensin-converting_enzyme	34,63	sodium	angiotensin-converting enzyme	MESH:D012964	1636	Chemical	Gene	intake|compound|START_ENTITY relation|nmod|intake polymorphism|nmod|relation polymorphism|nsubj|association association|nmod|insertion/deletion insertion/deletion|amod|END_ENTITY	Sex-dependent association between angiotensin-converting_enzyme insertion/deletion polymorphism and obesity in relation to sodium intake in children .
2442543	0	sodium	92,98	angiotensin-converting_enzyme	20,49	sodium	angiotensin-converting enzyme	MESH:D012964	1636	Chemical	Gene	diet|compound|START_ENTITY comparison|nmod|diet effects|dep|comparison effects|nmod|inhibition inhibition|amod|END_ENTITY	Diuretic effects of angiotensin-converting_enzyme inhibition : comparison of low and liberal sodium diet in hypertensive patients .
3310771	0	sodium	59,65	angiotensin-converting_enzyme	15,44	sodium	angiotensin-converting enzyme	MESH:D012964	1636	Chemical	Gene	handling|compound|START_ENTITY effects|nmod|handling effects|nmod|inhibition inhibition|amod|END_ENTITY	The effects of angiotensin-converting_enzyme inhibition on sodium handling in patients with advanced chronic_obstructive_pulmonary_disease .
6099390	0	sodium	18,24	angiotensin-converting_enzyme	28,57	sodium	angiotensin-converting enzyme	MESH:D012964	1636	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|amod|END_ENTITY	Effect of dietary sodium on angiotensin-converting_enzyme -LRB- ACE -RRB- inhibition and the acute hypotensive effect of enalapril -LRB- MK-421 -RRB- in essential hypertension .
8219659	0	sodium	61,67	angiotensin-converting_enzyme	11,40	sodium	angiotensin-converting enzyme	MESH:D012964	1636	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Effects of angiotensin-converting_enzyme inhibition on renal sodium handling after furosemide injection .
9171956	0	sodium	27,33	angiotensin-converting_enzyme	58,87	sodium	angiotensin-converting enzyme	MESH:D012964	24310(Tax:10116)	Chemical	Gene	monitor|compound|START_ENTITY Stimulation|nmod|monitor reduces|nsubj|Stimulation reduces|dobj|activity activity|amod|END_ENTITY	Stimulation of the gastric sodium monitor reduces hepatic angiotensin-converting_enzyme activity .
9247766	0	sodium	131,137	angiotensin-converting_enzyme	57,86	sodium	angiotensin-converting enzyme	MESH:D012964	1636	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Pharmacological demonstration of the additive effects of angiotensin-converting_enzyme inhibition and angiotensin_II antagonism in sodium depleted healthy subjects .
9260976	0	sodium	27,33	angiotensin-converting_enzyme	78,107	sodium	angiotensin-converting enzyme	MESH:D012964	1636	Chemical	Gene	retention|compound|START_ENTITY determinants|nmod|retention determinants|dep|effects effects|nmod|inhibition inhibition|amod|END_ENTITY	Intrarenal determinants of sodium retention in mild heart_failure : effects of angiotensin-converting_enzyme inhibition .
11230281	0	sodium	77,83	angiotensin_II	53,67	sodium	angiotensin II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	supplementation|compound|START_ENTITY supplementation|amod|END_ENTITY	Structural vascular changes in hypertension : role of angiotensin_II , dietary sodium supplementation , and sympathetic stimulation , alone and in combination in rats .
12013499	0	sodium	130,136	angiotensin_II	8,22	sodium	angiotensin II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY antagonism|dep|effect antagonism|compound|END_ENTITY	Chronic angiotensin_II antagonism with losartan in one-kidney , one clip hypertensive rats : effect on cardiac_hypertrophy , urinary sodium and water excretion and the natriuretic system .
1261210	0	sodium	17,23	angiotensin_II	58,72	sodium	angiotensin II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	influence|nmod|START_ENTITY intake|nsubj|influence intake|nmod|END_ENTITY	The influence of sodium intake on the pressor response to angiotensin_II in the unanaesthetized rat .
12691602	0	sodium	45,51	angiotensin_II	94,108	sodium	angiotensin II	MESH:D012964	183	Chemical	Gene	restriction|compound|START_ENTITY Decreased_insulin_sensitivity|nmod|restriction mediated|nsubjpass|Decreased_insulin_sensitivity mediated|nmod|effects effects|nmod|END_ENTITY	Decreased_insulin_sensitivity during dietary sodium restriction is not mediated by effects of angiotensin_II on insulin action .
1278105	0	sodium	13,19	angiotensin_II	51,65	sodium	angiotensin II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	intake|compound|START_ENTITY Influence|nmod|intake Influence|nmod|receptors receptors|compound|END_ENTITY	Influence of sodium intake on vascular and adrenal angiotensin_II receptors .
15806712	0	sodium	17,23	angiotensin_II	117,131	sodium	angiotensin II	MESH:D012964	11606(Tax:10090)	Chemical	Gene	intake|compound|START_ENTITY exacerbates|nsubj|intake exacerbates|dep|associated associated|nmod|overproduction overproduction|nmod|END_ENTITY	Elevated dietary sodium intake exacerbates myocardial_hypertrophy associated with cardiac-specific overproduction of angiotensin_II .
16467655	0	sodium	22,28	angiotensin_II	58,72	sodium	angiotensin II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	balance|compound|START_ENTITY balance|nmod|levels levels|compound|END_ENTITY	Effects of changes in sodium balance on plasma and kidney angiotensin_II levels in anesthetized and conscious Ren-2 transgenic_rats .
16890144	0	sodium	8,14	angiotensin_II	72,86	sodium	angiotensin II	MESH:D012964	183	Chemical	Gene	intake|compound|START_ENTITY modulates|nsubj|intake modulates|nmod|END_ENTITY	Dietary sodium intake modulates myocardial relaxation responsiveness to angiotensin_II .
17214984	0	sodium	18,24	angiotensin_II	91,105	sodium	angiotensin II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	alters|nsubj|START_ENTITY alters|nmod|infusion infusion|compound|END_ENTITY	Increased dietary sodium alters Fos expression in the lamina terminalis during intravenous angiotensin_II infusion .
17341566	0	sodium	12,18	angiotensin_II	33,47	sodium	angiotensin II	MESH:D012964	183	Chemical	Gene	START_ENTITY|dobj|concentrations concentrations|amod|END_ENTITY	Low dietary sodium and exogenous angiotensin_II infusion decrease plasma adiponectin concentrations in healthy men .
1834374	0	sodium	81,87	angiotensin_II	24,38	sodium	angiotensin II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	rejection|nmod|START_ENTITY END_ENTITY|nmod|rejection	Differential effects of angiotensin_II and noradrenaline on tubular rejection of sodium produced by ANP in rats .
1876234	0	sodium	8,14	angiotensin_II	49,63	sodium	angiotensin II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|receptors receptors|amod|END_ENTITY	Chronic sodium or chloride depletion upregulates angiotensin_II receptors in the anterior pituitary lobe of young rats .
1881047	0	sodium	67,73	angiotensin_II	33,47	sodium	angiotensin II	MESH:D012964	183	Chemical	Gene	transport|compound|START_ENTITY role|nmod|transport role|nmod|END_ENTITY	Potential role for local luminal angiotensin_II in proximal tubule sodium transport .
20571167	0	sodium	71,77	angiotensin_II	25,39	sodium	angiotensin II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	control|nmod|START_ENTITY END_ENTITY|nmod|control	Role of norepinephrine _ angiotensin_II in the neural control of renal sodium _ water handling in spontaneously hypertensive rats .
21143283	0	sodium	28,34	angiotensin_II	48,62	sodium	angiotensin II	MESH:D012964	183	Chemical	Gene	Regulation|nmod|START_ENTITY transport|nsubj|Regulation transport|nmod|END_ENTITY	Regulation of renal tubular sodium transport by angiotensin_II and atrial_natriuretic_factor .
215372	0	sodium	80,86	angiotensin_II	35,49	sodium	angiotensin II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	intake|compound|START_ENTITY variation|nmod|intake receptors|nmod|variation receptors|compound|END_ENTITY	Alterations of adrenal and uterine angiotensin_II receptors during variation of sodium intake and/or experimental hypertension .
2167792	0	sodium	113,119	angiotensin_II	85,99	sodium	angiotensin II	MESH:D012964	183	Chemical	Gene	loading|compound|START_ENTITY secondary|nmod|loading secondary|amod|aldosterone aldosterone|nmod|END_ENTITY	Role of atrial natriuretic factor in changes in the responsiveness of aldosterone to angiotensin_II secondary to sodium loading and depletion in man .
2184915	0	sodium	103,109	angiotensin_II	19,33	sodium	angiotensin II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	depletion|compound|START_ENTITY rats|nmod|depletion Down-regulation|nmod|rats Down-regulation|nmod|receptors receptors|amod|END_ENTITY	Down-regulation of angiotensin_II receptors in subfornical organ of young male rats by chronic dietary sodium depletion .
2331021	0	sodium	21,27	angiotensin_II	53,67	sodium	angiotensin II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	depletion|compound|START_ENTITY effects|nmod|depletion effects|nmod|receptors receptors|amod|END_ENTITY	Different effects of sodium or chloride depletion on angiotensin_II receptors in rats .
2527200	0	sodium	17,23	angiotensin_II	56,70	sodium	angiotensin II	MESH:D012964	183	Chemical	Gene	Effect|nmod|START_ENTITY secretion|nsubj|Effect secretion|nmod|stimulation stimulation|amod|END_ENTITY	Effect of plasma sodium on aldosterone secretion during angiotensin_II stimulation in normal humans .
2549153	0	sodium	10,16	angiotensin_II	84,98	sodium	angiotensin II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY intake|nsubj|Effect intake|nmod|END_ENTITY	Effect of sodium intake on phosphoinositides and inositol_trisphosphate response to angiotensin_II , K + and ACTH in rat glomerulosa cells .
2549161	0	sodium	94,100	angiotensin_II	4,18	sodium	angiotensin II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	intake|compound|START_ENTITY effect|nmod|intake END_ENTITY|dep|effect	-LSB- 3H -RSB- angiotensin_II binding to basolateral membranes from rat proximal renal tubule : effect of sodium intake and captopril .
2553328	0	sodium	53,59	angiotensin_II	35,49	sodium	angiotensin II	MESH:D012964	183	Chemical	Gene	intake|compound|START_ENTITY Alterations|nmod|intake Alterations|nmod|END_ENTITY	Alterations in cerebrospinal fluid angiotensin_II by sodium intake in patients with essential hypertension .
2558135	0	sodium	33,39	angiotensin_II	90,104	sodium	angiotensin II	MESH:D012964	183	Chemical	Gene	depletion|compound|START_ENTITY contribution|nmod|depletion axis|nsubj|contribution axis|nmod|END_ENTITY	Antihypertensive contribution of sodium depletion and the sympathetic axis during chronic angiotensin_II converting enzyme inhibition .
25827427	0	sodium	42,48	angiotensin_II	10,24	sodium	angiotensin II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	currents|compound|START_ENTITY END_ENTITY|nmod|currents	Effect of angiotensin_II on voltage-gated sodium currents in aortic baroreceptor neurons and arterial baroreflex sensitivity in heart_failure rats .
26347505	0	sodium	57,63	angiotensin_II	22,36	sodium	angiotensin II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	transporters|compound|START_ENTITY stimulates|dobj|transporters stimulates|nsubj|infusion infusion|compound|END_ENTITY	Short-term nonpressor angiotensin_II infusion stimulates sodium transporters in proximal tubule and distal nephron .
26347505	0	sodium	57,63	angiotensin_II	22,36	sodium	angiotensin II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	transporters|compound|START_ENTITY stimulates|dobj|transporters stimulates|nsubj|infusion infusion|compound|END_ENTITY	Short-term nonpressor angiotensin_II infusion stimulates sodium transporters in proximal tubule and distal nephron .
2697460	0	sodium	18,24	angiotensin_II	61,75	sodium	angiotensin II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	intake|compound|START_ENTITY Effect|nmod|intake reactivity|nsubj|Effect reactivity|nmod|END_ENTITY	Effect of dietary sodium intake on the pressor reactivity to angiotensin_II in rats with experimental cirrhosis_of_the_liver .
2757896	0	sodium	81,87	angiotensin_II	14,28	sodium	angiotensin II	MESH:D012964	183	Chemical	Gene	excretion|compound|START_ENTITY effect|nmod|excretion effect|nmod|END_ENTITY	The effect of angiotensin_II and noradrenaline alone and in combination on renal sodium excretion in man .
2848091	0	sodium	19,25	angiotensin_II	177,191	sodium	angiotensin II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	restriction|compound|START_ENTITY Effects|nmod|restriction Effects|dep|report report|nmod|sensitivity sensitivity|nmod|amide amide|amod|END_ENTITY	Effects of dietary sodium restriction on peptide stimulation of aldosterone secretion by the isolated perfused rat adrenal gland in situ : a report of exceptional sensitivity to angiotensin_II amide .
3028957	0	sodium	75,81	angiotensin_II	8,22	sodium	angiotensin II	MESH:D012964	183	Chemical	Gene	restriction|compound|START_ENTITY Role|nmod|restriction Role|nmod|END_ENTITY	Role of angiotensin_II in the hormonal , renal , and electrolyte response to sodium restriction .
3227050	0	sodium	65,71	angiotensin_II	30,44	sodium	angiotensin II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	loading|compound|START_ENTITY caused|nmod|loading caused|nsubj|responses responses|nmod|END_ENTITY	Enhanced pressor responses to angiotensin_II caused by excessive sodium loading in the pithed rat .
3375134	0	sodium	42,48	angiotensin_II	7,21	sodium	angiotensin II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	homeostasis|compound|START_ENTITY interdependence|nmod|homeostasis END_ENTITY|dep|interdependence	Plasma angiotensin_II : interdependence on sodium and calcium homeostasis .
3521337	0	sodium	11,17	angiotensin_II	31,45	sodium	angiotensin II	MESH:D012964	183	Chemical	Gene	excretion|compound|START_ENTITY excretion|nmod|END_ENTITY	Control of sodium excretion by angiotensin_II : intrarenal mechanisms and blood pressure regulation .
3760114	0	sodium	10,16	angiotensin_II	107,121	sodium	angiotensin II	MESH:D012964	183	Chemical	Gene	balance|compound|START_ENTITY Effect|nmod|balance aldosterone|nsubj|Effect aldosterone|nmod|infusion infusion|nmod|END_ENTITY	Effect of sodium balance and calcium channel-blocking drugs on plasma aldosterone responses to infusion of angiotensin_II in normal subjects and patients with essential hypertension .
3793196	0	sodium	62,68	angiotensin_II	22,36	sodium	angiotensin II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	intake|compound|START_ENTITY receptors|nmod|intake receptors|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of primate angiotensin_II receptors during altered sodium intake .
4052780	0	sodium	100,106	angiotensin_II	64,78	sodium	angiotensin II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	depletion|compound|START_ENTITY Modulation|nmod|depletion Modulation|nmod|END_ENTITY	Modulation of salt appetite by lateral ventricular infusions of angiotensin_II and carbachol during sodium depletion .
4285879	0	sodium	84,90	angiotensin_II	39,53	sodium	angiotensin II	MESH:D012964	183	Chemical	Gene	elimination|nmod|START_ENTITY END_ENTITY|nmod|elimination	-LSB- Influence of intravenous perfusion of angiotensin_II on the urinary elimination of sodium in edematous_cardiac patients -RSB- .
4286529	0	sodium	48,54	angiotensin_II	10,24	sodium	angiotensin II	MESH:D012964	183	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of angiotensin_II on active transport of sodium by toad bladder and skin .
454855	0	sodium	12,18	angiotensin_II	102,116	sodium	angiotensin II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY ions|nsubj|role ions|nmod|END_ENTITY	The role of sodium and potassium ions in the contractile response and development of tachyphylaxis to angiotensin_II on vascular smooth muscle .
455738	0	sodium	126,132	angiotensin_II	14,28	sodium	angiotensin II	MESH:D012964	183	Chemical	Gene	depletion|compound|START_ENTITY saralasin|nmod|depletion saralasin|nsubj|Effect Effect|nmod|antagonist antagonist|amod|END_ENTITY	Effect of the angiotensin_II antagonist saralasin on plasma aldosterone concentration and on blood pressure before and during sodium depletion in normal subjects .
477254	0	sodium	96,102	angiotensin_II	37,51	sodium	angiotensin II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	intake|compound|START_ENTITY END_ENTITY|nmod|intake	Evidence for the local occurrence of angiotensin_II in rat kidney and its modulation by dietary sodium intake and converting enzyme blockade .
556854	0	sodium	62,68	angiotensin_II	85,99	sodium	angiotensin II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	stimulation|nmod|START_ENTITY reabsorption|nsubj|stimulation reabsorption|nmod|END_ENTITY	Dose-dependent stimulation and inhibition of proximal tubular sodium reabsorption by angiotensin_II in the rat kidney .
573458	0	sodium	32,38	angiotensin_II	60,74	sodium	angiotensin II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	Stimulation|nmod|START_ENTITY reabsorption|nsubj|Stimulation reabsorption|nmod|END_ENTITY	Stimulation of proximal tubular sodium reabsorption by ile5 angiotensin_II in the rat kidney .
6092173	0	sodium	79,85	angiotensin_II	20,34	sodium	angiotensin II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	ions|compound|START_ENTITY action|nmod|ions site|nmod|action studies|nmod|site receptors|dep|studies receptors|compound|END_ENTITY	Solubilized adrenal angiotensin_II receptors : studies on the site of action of sodium and calcium ions , and on the role of disulfide bridges .
6249735	0	sodium	75,81	angiotensin_II	46,60	sodium	angiotensin II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	intake|compound|START_ENTITY Influence|nmod|intake actions|dep|Influence actions|nmod|END_ENTITY	Central actions and brain receptor binding of angiotensin_II : Influence of sodium intake .
6292538	0	sodium	19,25	angiotensin_II	35,49	sodium	angiotensin II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|receptors receptors|compound|END_ENTITY	Effects of dietary sodium on brain angiotensin_II receptors in spontaneously hypertensive rats .
6366501	0	sodium	74,80	angiotensin_II	44,58	sodium	angiotensin II	MESH:D012964	183	Chemical	Gene	antagonists|nmod|START_ENTITY antagonists|amod|END_ENTITY	A comparison of biological effects of three angiotensin_II antagonists in sodium depleted hypertensive patients .
6385344	0	sodium	77,83	angiotensin_II	135,149	sodium	angiotensin II	MESH:D012964	183	Chemical	Gene	intake|compound|START_ENTITY Angiotensin_II|nmod|intake Angiotensin_II|dep|is is|nsubj|infusion infusion|amod|END_ENTITY	Angiotensin_II analogue infusion test in renovascular_hypertension under low sodium intake and under spironolactone administration : is angiotensin_II analogue infusion test useful in determining the mode of treatment ?
6639746	0	sodium	114,120	angiotensin_II	64,78	sodium	angiotensin II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	excretion|compound|START_ENTITY urinary|dobj|excretion elicited|parataxis|urinary elicited|nmod|infusion infusion|nmod|END_ENTITY	Sodium_appetite elicited by intracerebroventricular infusion of angiotensin_II in the rat : I. Relation to urinary sodium excretion .
672437	0	sodium	99,105	angiotensin_II	44,58	sodium	angiotensin II	MESH:D012964	183	Chemical	Gene	depletion|compound|START_ENTITY analogues|nmod|depletion analogues|nsubj|Comparison Comparison|nmod|effects effects|nmod|END_ENTITY	Comparison of the biological effects of two angiotensin_II analogues in hypertensive patients with sodium depletion .
6756162	0	sodium	43,49	angiotensin_II	73,87	sodium	angiotensin II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	sequestration|compound|START_ENTITY biosynthesis|nmod|sequestration Stimulation|nmod|biosynthesis Stimulation|dep|role role|nmod|END_ENTITY	Stimulation of aldosterone biosynthesis by sodium sequestration : role of angiotensin_II .
6822640	0	sodium	88,94	angiotensin_II	57,71	sodium	angiotensin II	MESH:D012964	183	Chemical	Gene	intake|compound|START_ENTITY changes|nmod|intake END_ENTITY|nmod|changes	Dopaminergic modulation of aldosterone responsiveness to angiotensin_II with changes in sodium intake .
7002566	0	sodium	172,178	angiotensin_II	15,29	sodium	angiotensin II	MESH:D012964	183	Chemical	Gene	intakes|compound|START_ENTITY subjects|nmod|intakes analogues|nmod|subjects analogues|nsubj|Effects Effects|nmod|END_ENTITY	Effects of two angiotensin_II analogues on blood pressure , plasma aldosterone concentration , plasma renin activity and creatinine clearance in normal subjects on different sodium intakes .
7026131	0	sodium	104,110	angiotensin_II	7,21	sodium	angiotensin II	MESH:D012964	183	Chemical	Gene	intake|compound|START_ENTITY restriction|nmod|intake regulates|nmod|restriction regulates|nsubj|concentration concentration|compound|END_ENTITY	Plasma angiotensin_II concentration regulates vascular but not adrenal responsiveness to restriction of sodium intake in normal man .
7047005	0	sodium	51,57	angiotensin_II	30,44	sodium	angiotensin II	MESH:D012964	183	Chemical	Gene	restriction|compound|START_ENTITY END_ENTITY|nmod|restriction	Aldosterone responsiveness to angiotensin_II after sodium restriction in subjects with low renin essential hypertension .
7193170	0	sodium	99,105	angiotensin_II	33,47	sodium	angiotensin II	MESH:D012964	183	Chemical	Gene	diets|compound|START_ENTITY man|nmod|diets corticosteroids|nmod|man corticosteroids|nsubj|Effect Effect|nmod|infusions infusions|nmod|END_ENTITY	Effect of prolonged infusions of angiotensin_II on eight serum corticosteroids in man on different sodium diets .
7348020	0	sodium	87,93	angiotensin_II	24,38	sodium	angiotensin II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	elicit|nmod|START_ENTITY elicit|nsubj|injection injection|compound|END_ENTITY	Intracerebroventricular angiotensin_II injection does not elicit specific appetite for sodium in the rat .
7506698	0	sodium	67,73	angiotensin_II	14,28	sodium	angiotensin II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	changes|compound|START_ENTITY Regulation|nmod|changes Regulation|nmod|receptors receptors|amod|END_ENTITY	Regulation of angiotensin_II receptors in rat brain during dietary sodium changes .
7573486	0	sodium	51,57	angiotensin_II	19,33	sodium	angiotensin II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY END_ENTITY|nmod|concentration	Biphasic effect of angiotensin_II on intracellular sodium concentration in rat proximal tubules .
8190756	0	sodium	57,63	angiotensin_II	30,44	sodium	angiotensin II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	balance|compound|START_ENTITY interaction|nmod|balance interaction|nmod|END_ENTITY	Synergist interaction between angiotensin_II and DOCA on sodium and water balance in rats .
8477561	0	sodium	112,118	angiotensin_II	10,24	sodium	angiotensin II	MESH:D012964	183	Chemical	Gene	restriction|compound|START_ENTITY infused|nmod|restriction unaltered|advcl|infused response|dep|unaltered response|compound|END_ENTITY	Decreased angiotensin_II response but unaltered cardiovascular pressor response to infused norepinephrine after sodium restriction and converting enzyme inhibition .
875624	0	sodium	90,96	angiotensin_II	15,29	sodium	angiotensin II	MESH:D012964	183	Chemical	Gene	balances|compound|START_ENTITY analogous|nmod|balances analogous|nsubj|Effects Effects|nmod|END_ENTITY	Effects of two angiotensin_II analogous on blood pressure in normal subjects with various sodium balances .
884929	0	sodium	22,28	angiotensin_II	90,104	sodium	angiotensin II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY intake|nsubj|effect intake|nmod|END_ENTITY	The effect of dietary sodium intake on the blood pressure and cardiac output responses to angiotensin_II in unanaesthetized rats .
8904632	0	sodium	74,80	angiotensin_II	39,53	sodium	angiotensin II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|END_ENTITY	Modulation by locally produced luminal angiotensin_II of proximal tubular sodium reabsorption via an AT1 receptor .
8951724	0	sodium	50,56	angiotensin_II	14,28	sodium	angiotensin II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	content|compound|START_ENTITY END_ENTITY|nmod|content	The action of angiotensin_II on the intracellular sodium content of suspensions of rat proximal tubules .
8993849	0	sodium	28,34	angiotensin_II	48,62	sodium	angiotensin II	MESH:D012964	183	Chemical	Gene	Regulation|nmod|START_ENTITY transport|nsubj|Regulation transport|nmod|END_ENTITY	Regulation of renal tubular sodium transport by angiotensin_II and atrial_natriuretic_factor .
920808	0	sodium	46,52	angiotensin_II	22,36	sodium	angiotensin II	MESH:D012964	183	Chemical	Gene	excretion|compound|START_ENTITY Effects|nmod|excretion Effects|nmod|END_ENTITY	Effects of endogenous angiotensin_II on renal sodium excretion and renal hemodynamics .
9387775	0	sodium	72,78	angiotensin_II	29,43	sodium	angiotensin II	MESH:D012964	183	Chemical	Gene	-RSB-|compound|START_ENTITY Effect|nmod|-RSB- Effect|nmod|END_ENTITY	-LSB- Effect of microinjection of angiotensin_II into area postrema on renal sodium excretion -RSB- .
9389507	0	sodium	21,27	angiotensin_II	43,57	sodium	angiotensin II	MESH:D012964	24179(Tax:10116)	Chemical	Gene	restriction|compound|START_ENTITY restriction|nmod|receptors receptors|amod|END_ENTITY	Influence of dietary sodium restriction on angiotensin_II receptors in rat adrenals .
9463638	0	sodium	75,81	angiotensin_II	11,25	sodium	angiotensin II	MESH:D012964	183	Chemical	Gene	deplete|compound|START_ENTITY tone|nmod|deplete basal|dobj|tone contributes|xcomp|basal contributes|nsubj|END_ENTITY	Endogenous angiotensin_II contributes to basal peripheral vascular tone in sodium deplete but not sodium replete man .
9856973	0	sodium	51,57	angiotensin_II	24,38	sodium	angiotensin II	MESH:D012964	183	Chemical	Gene	pump|compound|START_ENTITY regulates|nmod|pump regulates|dobj|response response|amod|END_ENTITY	Bromocriptine regulates angiotensin_II response on sodium pump in proximal tubules .
10024318	0	sodium	14,20	angiotensin_II_subtype_2_receptor	49,82	sodium	angiotensin II subtype 2 receptor	MESH:D012964	24182(Tax:10116)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	Intracellular sodium modulates the expression of angiotensin_II_subtype_2_receptor in PC12W cells .
2983253	0	sodium	92,98	angiotensin_converting_enzyme	14,43	sodium	angiotensin converting enzyme	MESH:D012964	1636	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|inhibitor inhibitor|amod|END_ENTITY	Effect of the angiotensin_converting_enzyme inhibitor , captopril -LRB- SQ14 ,225 -RRB- , on orthostatic sodium and water retention in patients with idiopathic_edema .
19064667	0	sodium	54,60	ankyrin_G	128,137	sodium	ankyrin G	MESH:D012964	288	Chemical	Gene	channels|compound|START_ENTITY organization|nmod|channels contributes|nmod|organization contributes|advcl|regulating regulating|nmod|END_ENTITY	Protein kinase CK2 contributes to the organization of sodium channels in axonal membranes by regulating their interactions with ankyrin_G .
24903831	0	sodium	37,43	ankyrin_G	90,99	sodium	ankyrin G	MESH:D012964	288	Chemical	Gene	Nav_1|compound|START_ENTITY Nav_1|dep|interacts interacts|nmod|END_ENTITY	Tetrodotoxin-resistant voltage-gated sodium channel Nav_1 .8 constitutively interacts with ankyrin_G .
124056	0	sodium	74,80	antidiuretic_hormone	15,35	sodium	antidiuretic hormone	MESH:D012964	551	Chemical	Gene	-RSB-|compound|START_ENTITY -LSB-|nmod|-RSB- -LSB-|dobj|effect effect|nmod|END_ENTITY	-LSB- The effect of antidiuretic_hormone and catecholamines on transepithelial sodium transport -RSB- .
13221777	0	sodium	7,13	antidiuretic_hormone	57,77	sodium	antidiuretic hormone	MESH:D012964	551	Chemical	Gene	uptake|nsubj|START_ENTITY uptake|nmod|END_ENTITY	Active sodium uptake by the toad and its response to the antidiuretic_hormone .
17499799	0	sodium	121,127	antidiuretic_hormone	90,110	sodium	antidiuretic hormone	MESH:D012964	551	Chemical	Gene	concentration|compound|START_ENTITY concentration|compound|END_ENTITY	The effects of long-term administration of oral desmopressin on the baseline secretion of antidiuretic_hormone and serum sodium concentration for the treatment of nocturia : a circadian study .
2147645	0	sodium	116,122	antidiuretic_hormone	50,70	sodium	antidiuretic hormone	MESH:D012964	551	Chemical	Gene	excretion|nmod|START_ENTITY aldosterone|dobj|excretion aldosterone|nsubj|Effect Effect|nmod|loading loading|nmod|levels levels|nmod|AVP AVP|amod|END_ENTITY	Effect of acute water loading on plasma levels of antidiuretic_hormone AVP aldosterone , ANP fractional excretion of sodium and plasma and urine osmolalities in myxedema .
313883	0	sodium	15,21	antidiuretic_hormone	35,55	sodium	antidiuretic hormone	MESH:D012964	551	Chemical	Gene	Stimulation|nmod|START_ENTITY transport|nsubj|Stimulation transport|nmod|END_ENTITY	Stimulation of sodium transport by antidiuretic_hormone in bullfrog intestine .
493037	0	sodium	62,68	antidiuretic_hormone	23,43	sodium	antidiuretic hormone	MESH:D012964	551	Chemical	Gene	intake|compound|START_ENTITY related|nmod|intake levels|acl|related levels|compound|END_ENTITY	-LSB- Variations in urinary antidiuretic_hormone levels related to sodium intake -LRB- author 's transl -RRB- -RSB- .
6271208	0	sodium	80,86	antidiuretic_hormone	11,31	sodium	antidiuretic hormone	MESH:D012964	551	Chemical	Gene	transport|compound|START_ENTITY Effects|nmod|transport Effects|nmod|END_ENTITY	Effects of antidiuretic_hormone on kinetic and energetic determinants of active sodium transport in frog skin .
6290664	0	sodium	39,45	antidiuretic_hormone	74,94	sodium	antidiuretic hormone	MESH:D012964	551	Chemical	Gene	transport|compound|START_ENTITY stimulation|nmod|transport sensitivity|nmod|stimulation sensitivity|nmod|END_ENTITY	Enhanced sensitivity to stimulation of sodium transport and cyclic_AMP by antidiuretic_hormone after Ca2 + depletion of isolated frog skin epithelium .
917179	0	sodium	62,68	antidiuretic_hormone	18,38	sodium	antidiuretic hormone	MESH:D012964	551	Chemical	Gene	restriction|compound|START_ENTITY Concentrations|nmod|restriction Concentrations|nmod|END_ENTITY	Concentrations of antidiuretic_hormone in plasma during human sodium restriction .
11055473	0	sodium	76,82	atrial_natriuretic_factor	20,45	sodium	atrial natriuretic factor	MESH:D012964	4878	Chemical	Gene	loading|compound|START_ENTITY responses|nmod|loading responses|nmod|END_ENTITY	Normal responses of atrial_natriuretic_factor and renal tubular function to sodium loading in hypertension-prone humans .
11433187	0	sodium	117,123	atrial_natriuretic_factor	84,109	sodium	atrial natriuretic factor	MESH:D012964	24602(Tax:10116)	Chemical	Gene	intake|compound|START_ENTITY END_ENTITY|nmod|intake	Studies on potential involvement of protein kinase C in glomerular insensitivity to atrial_natriuretic_factor on low sodium intake .
1533286	0	sodium	21,27	atrial_natriuretic_factor	38,63	sodium	atrial natriuretic factor	MESH:D012964	24602(Tax:10116)	Chemical	Gene	intake|compound|START_ENTITY intake|nmod|END_ENTITY	Effect of changes in sodium intake on atrial_natriuretic_factor -LRB- ANF -RRB- and peptides derived from the N terminus of the ANF prohormone in the rat .
1534832	0	sodium	52,58	atrial_natriuretic_factor	13,38	sodium	atrial natriuretic factor	MESH:D012964	4878	Chemical	Gene	restriction|compound|START_ENTITY Responses|nmod|restriction Responses|nmod|END_ENTITY	Responses of atrial_natriuretic_factor to long-term sodium restriction in mild to moderate hypertension .
1655267	0	sodium	78,84	atrial_natriuretic_factor	11,36	sodium	atrial natriuretic factor	MESH:D012964	24602(Tax:10116)	Chemical	Gene	loading|compound|START_ENTITY natriuresis|nmod|loading involved|nmod|natriuresis involved|nsubjpass|END_ENTITY	Endogenous atrial_natriuretic_factor is involved in the natriuresis following sodium loading in rats with chronic_heart_failure .
1708021	0	sodium	58,64	atrial_natriuretic_factor	3,28	sodium	atrial natriuretic factor	MESH:D012964	4878	Chemical	Gene	excretion|compound|START_ENTITY regulator|nmod|excretion regulator|nsubj|END_ENTITY	Is atrial_natriuretic_factor a physiological regulator of sodium excretion ?
1829768	0	sodium	55,61	atrial_natriuretic_factor	22,47	sodium	atrial natriuretic factor	MESH:D012964	4878	Chemical	Gene	loading|compound|START_ENTITY due|nmod|loading release|amod|due release|nmod|END_ENTITY	Attenuated release of atrial_natriuretic_factor due to sodium loading in salt-sensitive essential hypertension .
1831860	0	sodium	37,43	atrial_natriuretic_factor	8,33	sodium	atrial natriuretic factor	MESH:D012964	4878	Chemical	Gene	retention|compound|START_ENTITY Role|nmod|retention Role|nmod|END_ENTITY	Role of atrial_natriuretic_factor in sodium and water retention in patients with schistosomal_hepatic_fibrosis .
2137092	0	sodium	13,19	atrial_natriuretic_factor	31,56	sodium	atrial natriuretic factor	MESH:D012964	24602(Tax:10116)	Chemical	Gene	balance|compound|START_ENTITY Influence|nmod|balance Influence|nmod|END_ENTITY	Influence of sodium balance on atrial_natriuretic_factor in rats with one-kidney , one-clip renal hypertension .
2138423	0	sodium	79,85	atrial_natriuretic_factor	17,42	sodium	atrial natriuretic factor	MESH:D012964	100294648(Tax:9940)	Chemical	Gene	status|compound|START_ENTITY changes|nmod|status effect|nmod|changes modulation|nmod|effect actions|dep|modulation actions|nmod|END_ENTITY	Renal actions of atrial_natriuretic_factor : modulation of effect by changes in sodium status and aldosterone .
2145876	0	sodium	67,73	atrial_natriuretic_factor	4,29	sodium	atrial natriuretic factor	MESH:D012964	608289(Tax:9615)	Chemical	Gene	excretion|compound|START_ENTITY regulation|nmod|excretion hormonal|nmod|regulation hormonal|nsubj|END_ENTITY	The atrial_natriuretic_factor hormonal system in the regulation of sodium excretion in dogs with experimental heart_failure .
2414808	0	sodium	11,17	atrial_natriuretic_factor	73,98	sodium	atrial natriuretic factor	MESH:D012964	4878	Chemical	Gene	Effects|nmod|START_ENTITY pump|nsubj|Effects pump|nmod|relaxation relaxation|acl|induced induced|nmod|END_ENTITY	Effects of sodium pump inhibition on the relaxation induced by synthetic atrial_natriuretic_factor -LRB- ANF -RRB- and sodium_nitroprusside .
2521228	0	sodium	21,27	atrial_natriuretic_factor	43,68	sodium	atrial natriuretic factor	MESH:D012964	608289(Tax:9615)	Chemical	Gene	Alterations|nmod|START_ENTITY Alterations|nmod|variables variables|compound|END_ENTITY	Alterations in serum sodium in relation to atrial_natriuretic_factor and other neuroendocrine variables in experimental pacing-induced heart_failure .
2522979	0	sodium	86,92	atrial_natriuretic_factor	20,45	sodium	atrial natriuretic factor	MESH:D012964	24602(Tax:10116)	Chemical	Gene	reabsorption|compound|START_ENTITY tubule|dobj|reabsorption tubule|nsubj|Effect Effect|nmod|END_ENTITY	Effect of synthetic atrial_natriuretic_factor on superficial and deep proximal tubule sodium reabsorption .
2529408	0	sodium	10,16	atrial_natriuretic_factor	62,87	sodium	atrial natriuretic factor	MESH:D012964	4878	Chemical	Gene	intake|compound|START_ENTITY Effect|nmod|intake Effect|nmod|levels levels|nmod|END_ENTITY	Effect of sodium intake on fasting and postprandial levels of atrial_natriuretic_factor in humans .
2934063	0	sodium	54,60	atrial_natriuretic_factor	12,37	sodium	atrial natriuretic factor	MESH:D012964	24602(Tax:10116)	Chemical	Gene	excretion|compound|START_ENTITY reduces|dobj|excretion reduces|nsubj|Antisera Antisera|nmod|END_ENTITY	Antisera to atrial_natriuretic_factor reduces urinary sodium excretion and increases plasma renin activity in rats .
2948752	0	sodium	18,24	atrial_natriuretic_factor	67,92	sodium	atrial natriuretic factor	MESH:D012964	4878	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of dietary sodium on plasma concentration of immunoreactive atrial_natriuretic_factor in normal humans .
2964552	0	sodium	10,16	atrial_natriuretic_factor	24,49	sodium	atrial natriuretic factor	MESH:D012964	24602(Tax:10116)	Chemical	Gene	ion|compound|START_ENTITY ion|nmod|release release|compound|END_ENTITY	Effect of sodium ion on atrial_natriuretic_factor release from rat hypothalamic fragments .
2976331	0	sodium	42,48	atrial_natriuretic_factor	83,108	sodium	atrial natriuretic factor	MESH:D012964	4878	Chemical	Gene	cirrhotics|compound|START_ENTITY immersion|nmod|cirrhotics Hyperresponsiveness|nmod|immersion Hyperresponsiveness|dep|role role|nmod|END_ENTITY	Hyperresponsiveness to water immersion in sodium retaining cirrhotics : the role of atrial_natriuretic_factor .
4001134	0	sodium	149,155	atrial_natriuretic_factor	33,58	sodium	atrial natriuretic factor	MESH:D012964	24602(Tax:10116)	Chemical	Gene	excretion|compound|START_ENTITY changes|nmod|excretion reduces|nmod|changes reduces|nsubj|infusion infusion|nmod|doses doses|nmod|END_ENTITY	Chronic infusion of low doses of atrial_natriuretic_factor -LRB- ANF Arg_101-Tyr 126 -RRB- reduces blood pressure in conscious SHR without apparent changes in sodium excretion .
8027224	0	sodium	105,111	atrial_natriuretic_factor	12,37	sodium	atrial natriuretic factor	MESH:D012964	4878	Chemical	Gene	deficiency|compound|START_ENTITY adaptation|nmod|deficiency -RSB-|nmod|adaptation role|dep|-RSB- role|nmod|ANF ANF|compound|END_ENTITY	The role of atrial_natriuretic_factor -LSB- alpha-human ANF - -LRB- 99-126 -RRB- -RSB- in the hormonal and renal adaptation to sodium deficiency .
8214924	0	sodium	46,52	atrial_natriuretic_factor	8,33	sodium	atrial natriuretic factor	MESH:D012964	4878	Chemical	Gene	excretion|compound|START_ENTITY END_ENTITY|nmod|excretion	Role of atrial_natriuretic_factor in impaired sodium excretion of normocapnic and hypercapnic patients with chronic_obstructive_lung_disease .
8306484	0	sodium	27,33	atrial_natriuretic_factor	50,75	sodium	atrial natriuretic factor	MESH:D012964	4878	Chemical	Gene	effect|nmod|START_ENTITY diets|nsubj|effect diets|nmod|END_ENTITY	The effect of low and high sodium diets on plasma atrial_natriuretic_factor , the renin-aldosterone system and blood pressure in subjects with essential hypertension .
8869083	0	sodium	105,111	atrial_natriuretic_factor	72,97	sodium	atrial natriuretic factor	MESH:D012964	24602(Tax:10116)	Chemical	Gene	rats|compound|START_ENTITY END_ENTITY|nmod|rats	Inhibition of cGMP-phosphodiesterase restores the glomerular effects of atrial_natriuretic_factor in low sodium diet rats .
1340660	0	sodium	5,11	atrial_natriuretic_peptide	13,39	sodium	atrial natriuretic peptide	MESH:D012964	4878	Chemical	Gene	START_ENTITY|appos|pressure pressure|compound|END_ENTITY	Body sodium , atrial_natriuretic_peptide and blood pressure in diabetes_mellitus .
1535825	0	sodium	64,70	atrial_natriuretic_peptide	26,52	sodium	atrial natriuretic peptide	MESH:D012964	100294648(Tax:9940)	Chemical	Gene	intake|compound|START_ENTITY suppresses|dobj|intake suppresses|nsubj|administration administration|nmod|END_ENTITY	Central administration of atrial_natriuretic_peptide suppresses sodium and water intake of sheep .
15684587	0	sodium	39,45	atrial_natriuretic_peptide	83,109	sodium	atrial natriuretic peptide	MESH:D012964	4878	Chemical	Gene	absorption|compound|START_ENTITY Involvement|nmod|absorption Involvement|nmod|END_ENTITY	Involvement of drinking and intestinal sodium absorption in hyponatremic effect of atrial_natriuretic_peptide in seawater eels .
1828456	0	sodium	60,66	atrial_natriuretic_peptide	19,45	sodium	atrial natriuretic peptide	MESH:D012964	24602(Tax:10116)	Chemical	Gene	excretion|compound|START_ENTITY regulating|dobj|excretion END_ENTITY|advcl|regulating	Role of endogenous atrial_natriuretic_peptide in regulating sodium excretion in spontaneously hypertensive rats .
2139545	0	sodium	38,44	atrial_natriuretic_peptide	8,34	sodium	atrial natriuretic peptide	MESH:D012964	24602(Tax:10116)	Chemical	Gene	balance|compound|START_ENTITY END_ENTITY|nmod|balance	Role of atrial_natriuretic_peptide in sodium balance in conscious spontaneously hypertensive rats .
2151006	0	sodium	76,82	atrial_natriuretic_peptide	11,37	sodium	atrial natriuretic peptide	MESH:D012964	24602(Tax:10116)	Chemical	Gene	change|nmod|START_ENTITY Effects|dep|change Effects|nmod|END_ENTITY	Effects of atrial_natriuretic_peptide on brain_oedema : the change of water , sodium , and potassium contents in the brain .
2151754	0	sodium	62,68	atrial_natriuretic_peptide	32,58	sodium	atrial natriuretic peptide	MESH:D012964	24602(Tax:10116)	Chemical	Gene	balance|compound|START_ENTITY Effect|nmod|balance Effect|nmod|infusion infusion|nmod|END_ENTITY	Effect of a chronic infusion of atrial_natriuretic_peptide on sodium balance in normotensive and two-kidney , one-clip hypertensive rats .
2822798	0	sodium	75,81	atrial_natriuretic_peptide	4,30	sodium	atrial natriuretic peptide	MESH:D012964	24602(Tax:10116)	Chemical	Gene	balance|compound|START_ENTITY alterations|nmod|balance effect|nmod|alterations receptor|dep|effect receptor|compound|END_ENTITY	Rat atrial_natriuretic_peptide vascular receptor : effect of alterations in sodium balance and of DOC hypertension .
2892605	0	sodium	13,19	atrial_natriuretic_peptide	67,93	sodium	atrial natriuretic peptide	MESH:D012964	24602(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY Influence|nmod|concentration END_ENTITY|nsubj|Influence	Influence of sodium concentration in cerebrospinal fluid on plasma atrial_natriuretic_peptide in conscious rats .
2937808	0	sodium	52,58	atrial_natriuretic_peptide	8,34	sodium	atrial natriuretic peptide	MESH:D012964	24602(Tax:10116)	Chemical	Gene	excretion|compound|START_ENTITY Role|nmod|excretion Role|nmod|END_ENTITY	Role of atrial_natriuretic_peptide in adaptation of sodium excretion with reduced renal mass .
7657277	0	sodium	79,85	atrial_natriuretic_peptide	12,38	sodium	atrial natriuretic peptide	MESH:D012964	4878	Chemical	Gene	delivery|compound|START_ENTITY increasing|dobj|delivery Reversal|advcl|increasing Reversal|nmod|resistance resistance|amod|END_ENTITY	Reversal of atrial_natriuretic_peptide resistance by increasing distal tubular sodium delivery in patients with decompensated cirrhosis .
7867228	0	sodium	128,134	atrial_natriuretic_peptide	10,36	sodium	atrial natriuretic peptide	MESH:D012964	24602(Tax:10116)	Chemical	Gene	pump|compound|START_ENTITY inhibition|nmod|pump evidence|nmod|inhibition Effect|dep|evidence Effect|nmod|END_ENTITY	Effect of atrial_natriuretic_peptide on cellular element concentrations in rat proximal tubules : evidence for inhibition of the sodium pump .
8275799	0	sodium	94,100	atrial_natriuretic_peptide	52,78	sodium	atrial natriuretic peptide	MESH:D012964	24602(Tax:10116)	Chemical	Gene	response|nmod|START_ENTITY END_ENTITY|nmod|response	Effect of hypothyroidism on the in vitro release of atrial_natriuretic_peptide in response to sodium challenge in rats .
8827780	0	sodium	66,72	atrial_natriuretic_peptide	36,62	sodium	atrial natriuretic peptide	MESH:D012964	24602(Tax:10116)	Chemical	Gene	intake|compound|START_ENTITY END_ENTITY|nmod|intake	Regulation of the renal response to atrial_natriuretic_peptide by sodium intake in preweaned rats .
9222431	0	sodium	92,98	atrial_natriuretic_peptide	28,54	sodium	atrial natriuretic peptide	MESH:D012964	24602(Tax:10116)	Chemical	Gene	intake|compound|START_ENTITY control|nmod|intake interaction|nmod|control interaction|nmod|END_ENTITY	Central interaction between atrial_natriuretic_peptide and angiotensin_II in the control of sodium intake and excretion in female rats .
19056495	0	sodium	69,75	beta-site_APP-cleaving_enzyme_1	26,57	sodium	beta-site APP-cleaving enzyme 1	MESH:D012964	23821(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|nmod|channel	Non-proteolytic effect of beta-site_APP-cleaving_enzyme_1 -LRB- BACE1 -RRB- on sodium channel function .
10967372	0	sodium	59,65	beta1	38,43	sodium	beta1	MESH:D012964	3779	Chemical	Gene	pump|compound|START_ENTITY subunit|nmod|pump subunit|amod|END_ENTITY	Trinucleotide repeat expansion in the beta1 subunit of the sodium pump in manic-depression illness : a negative study .
11263970	0	sodium	16,22	beta1	63,68	sodium	beta1	MESH:D012964	3779	Chemical	Gene	channel|compound|START_ENTITY affected|nsubjpass|channel affected|nmod|mutation mutation|amod|END_ENTITY	Skeletal muscle sodium channel is affected by an epileptogenic beta1 subunit mutation .
11922146	0	sodium	64,70	beta1	87,92	sodium	beta1	MESH:D012964	10678	Chemical	Gene	currents|compound|START_ENTITY currents|nmod|and_beta3 and_beta3|amod|END_ENTITY	Differential modulation of sodium channel gating and persistent sodium currents by the beta1 , beta2 , _ and_beta3 subunits .
12486163	0	sodium	41,47	beta1	56,61	sodium	beta1	MESH:D012964	3779	Chemical	Gene	analysis|nmod|START_ENTITY channel|nsubj|analysis channel|xcomp|responsible responsible|nsubj|mutation mutation|amod|END_ENTITY	Functional and biochemical analysis of a sodium channel beta1 subunit mutation responsible for generalized_epilepsy_with_febrile_seizures_plus_type_1 .
15272007	0	sodium	46,52	beta1	61,66	sodium	beta1	MESH:D012964	3779	Chemical	Gene	subunits|compound|START_ENTITY subunits|compound|END_ENTITY	Tyrosine-phosphorylated and nonphosphorylated sodium channel beta1 subunits are differentially localized in cardiac myocytes .
15316006	0	sodium	71,77	beta1	33,38	sodium	beta1	MESH:D012964	3779	Chemical	Gene	function|compound|START_ENTITY modulates|dobj|function modulates|nsubj|component component|nmod|subunit subunit|amod|END_ENTITY	The sialic_acid component of the beta1 subunit modulates voltage-gated sodium channel function .
15922564	0	sodium	63,69	beta1	28,33	sodium	beta1	MESH:D012964	3779	Chemical	Gene	channel|compound|START_ENTITY subunit|nmod|channel subunit|amod|END_ENTITY	An epilepsy mutation in the beta1 subunit of the voltage-gated sodium channel results in reduced channel sensitivity to phenytoin .
17629415	0	sodium	150,156	beta1	74,79	sodium	beta1	MESH:D012964	3779	Chemical	Gene	function|compound|START_ENTITY modulation|nmod|function reduce|dobj|modulation reduce|nsubj|mutations mutations|amod|END_ENTITY	Generalized_epilepsy_with_febrile_seizures plus-associated sodium channel beta1 subunit mutations severely reduce beta subunit-mediated modulation of sodium channel function .
17629415	0	sodium	59,65	beta1	74,79	sodium	beta1	MESH:D012964	3779	Chemical	Gene	mutations|compound|START_ENTITY mutations|amod|END_ENTITY	Generalized_epilepsy_with_febrile_seizures plus-associated sodium channel beta1 subunit mutations severely reduce beta subunit-mediated modulation of sodium channel function .
17868089	0	sodium	64,70	beta1	79,84	sodium	beta1	MESH:D012964	3779	Chemical	Gene	inactivation|nmod|START_ENTITY allele|nmod|inactivation channel|nsubj|allele channel|dobj|Scn1b Scn1b|amod|END_ENTITY	Floxed allele for conditional inactivation of the voltage-gated sodium channel beta1 subunit Scn1b .
18941776	0	sodium	32,38	beta1	101,106	sodium	beta1	MESH:D012964	3779	Chemical	Gene	channel|compound|START_ENTITY inactivation|nmod|channel impeded|nsubjpass|inactivation impeded|nmod|co-expression co-expression|nmod|subunit subunit|amod|END_ENTITY	Slow inactivation of the NaV1 .4 sodium channel in mammalian cells is impeded by co-expression of the beta1 subunit .
16306410	0	sodium	34,40	beta2	49,54	sodium	beta2	MESH:D012964	15130(Tax:10090)	Chemical	Gene	subunit|compound|START_ENTITY subunit|amod|END_ENTITY	Upregulation of the voltage-gated sodium channel beta2 subunit in neuropathic_pain models : characterization of expression in injured and non-injured primary sensory neurons .
16847056	0	sodium	63,69	beta2	32,37	sodium	beta2	MESH:D012964	10242	Chemical	Gene	gating|compound|START_ENTITY effects|nmod|gating effects|nmod|subunit subunit|amod|END_ENTITY	Isoform-specific effects of the beta2 subunit on voltage-gated sodium channel gating .
16870743	0	sodium	62,68	beta2	15,20	sodium	beta2	MESH:D012964	15130(Tax:10090)	Chemical	Gene	channels|compound|START_ENTITY regulate|dobj|channels subunits|ccomp|regulate subunits|nsubj|END_ENTITY	Sodium channel beta2 subunits regulate tetrodotoxin-sensitive sodium channels in small dorsal root ganglion neurons and modulate the response to pain .
9295116	0	sodium	79,85	beta2	46,51	sodium	beta2	MESH:D012964	10242	Chemical	Gene	channel|compound|START_ENTITY localization|nmod|channel localization|nmod|subunit subunit|amod|END_ENTITY	Structure and chromosomal localization of the beta2 subunit of the human brain sodium channel .
15664175	0	sodium	96,102	beta4	61,66	sodium	beta4	MESH:D012964	10381	Chemical	Gene	current|compound|START_ENTITY mechanism|nmod|current block|nmod|mechanism block|nmod|tail tail|nmod|END_ENTITY	Open-channel block by the cytoplasmic tail of sodium channel beta4 as a mechanism for resurgent sodium current .
17644063	0	sodium	54,60	beta4	69,74	sodium	beta4	MESH:D012964	140489(Tax:10090)	Chemical	Gene	subunit|compound|START_ENTITY subunit|amod|END_ENTITY	BACE1 modulates filopodia-like protrusions induced by sodium channel beta4 subunit .
11259505	0	sodium	33,39	beta_1	48,54	sodium	beta 1	MESH:D012964	3779	Chemical	Gene	subunit|compound|START_ENTITY subunit|compound|END_ENTITY	The intracellular segment of the sodium channel beta_1 subunit is required for its efficient association with the channel alpha subunit .
12220575	0	sodium	44,50	beta_1	104,110	sodium	beta 1	MESH:D012964	10678	Chemical	Gene	channels|compound|START_ENTITY modulation|dep|channels expressed|nsubj|modulation expressed|nmod|END_ENTITY	Functional modulation of human brain Nav1 .3 sodium channels , expressed in mammalian cells , by auxiliary beta_1 , beta_2_and_beta_3 subunits .
7852416	0	sodium	70,76	beta_1	32,38	sodium	beta 1	MESH:D012964	3779	Chemical	Gene	channels|compound|START_ENTITY subunits|nmod|channels IIA|dobj|subunits IIA|nsubj|co-expression co-expression|nmod|END_ENTITY	Functional co-expression of the beta_1 and type IIA alpha subunits of sodium channels in a mammalian cell line .
8666261	0	sodium	33,39	beta_1	48,54	sodium	beta 1	MESH:D012964	3779	Chemical	Gene	encoding|dobj|START_ENTITY cDNA|acl|encoding Cloning|nmod|cDNA channel|nsubj|Cloning channel|dobj|subunit subunit|amod|END_ENTITY	Cloning of the cDNA encoding the sodium channel beta_1 subunit from rabbit .
8786355	0	sodium	101,107	beta_1	30,36	sodium	beta 1	MESH:D012964	3779	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Functional association of the beta_1 subunit with human cardiac -LRB- hH1 -RRB- and rat skeletal muscle -LRB- mu 1 -RRB- sodium channel alpha subunits expressed in Xenopus oocytes .
8887969	0	sodium	11,17	beta_1	4,10	sodium	beta 1	MESH:D012964	3779	Chemical	Gene	subunit|compound|START_ENTITY subunit|amod|END_ENTITY	The beta_1 sodium channel subunit modifies the interactions of neurotoxins and local anesthetics with the rat brain IIA alpha sodium channel in isolated membranes but not in intact cells .
8887969	0	sodium	126,132	beta_1	4,10	sodium	beta 1	MESH:D012964	3779	Chemical	Gene	channel|compound|START_ENTITY modifies|nmod|channel modifies|nsubj|subunit subunit|amod|END_ENTITY	The beta_1 sodium channel subunit modifies the interactions of neurotoxins and local anesthetics with the rat brain IIA alpha sodium channel in isolated membranes but not in intact cells .
8921962	0	sodium	34,40	beta_1	12,18	sodium	beta 1	MESH:D012964	15129(Tax:10090)	Chemical	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	Loss of the beta_1 subunit of the sodium pump during lymphocyte differentiation .
9224938	0	sodium	50,56	beta_1	28,34	sodium	beta 1	MESH:D012964	15129(Tax:10090)	Chemical	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	Inducible expression of the beta_1 subunit of the sodium pump .
2540021	0	sodium	53,59	bradykinin	20,30	sodium	bradykinin	MESH:D012964	3827	Chemical	Gene	channels|compound|START_ENTITY channels|compound|END_ENTITY	Interaction between bradykinin and voltage-sensitive sodium channels in myelinated nerve fibers .
4785033	0	sodium	107,113	bradykinin	87,97	sodium	bradykinin	MESH:D012964	3827	Chemical	Gene	excretion|compound|START_ENTITY END_ENTITY|nmod|excretion	Increase of kinin in urine after partial occlusion of the renal vein and the effect of bradykinin on renal sodium excretion .
5032521	0	sodium	45,51	bradykinin	14,24	sodium	bradykinin	MESH:D012964	478666(Tax:9615)	Chemical	Gene	reabsorption|compound|START_ENTITY END_ENTITY|nmod|reabsorption	The effect of bradykinin on proximal tubular sodium reabsorption in the dog : evidence for functional nephron heterogeneity .
8267942	0	sodium	48,54	bradykinin	34,44	sodium	bradykinin	MESH:D012964	478666(Tax:9615)	Chemical	Gene	depletion|compound|START_ENTITY END_ENTITY|nmod|depletion	Stimulation of renal interstitial bradykinin by sodium depletion .
11585578	0	sodium	71,77	c-fos	38,43	sodium	c-fos	MESH:D012964	314322(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|nmod|channels	Magnetic stimulation induces neuronal c-fos via tetrodotoxin-sensitive sodium channels in organotypic cortex brain slices of the rat .
10684611	0	sodium	43,49	calmodulin	70,80	sodium	calmodulin	MESH:D012964	808	Chemical	Gene	channel|compound|START_ENTITY channel|nmod|END_ENTITY	Novel interaction of the voltage-dependent sodium channel -LRB- VDSC -RRB- with calmodulin : does VDSC acquire calmodulin-mediated Ca2 + - sensitivity ?
24486012	0	sodium	82,88	connexin43	45,55	sodium	connexin43	MESH:D012964	2697	Chemical	Gene	channels|compound|START_ENTITY role|nmod|channels role|nmod|END_ENTITY	Old cogs , new tricks : a scaffolding role for connexin43 and a junctional role for sodium channels ?
10215647	0	sodium	54,60	cyclooxygenase-2	34,50	sodium	cyclooxygenase-2	MESH:D012964	5743	Chemical	Gene	balance|compound|START_ENTITY END_ENTITY|nmod|balance	Effects of specific inhibition of cyclooxygenase-2 on sodium balance , hemodynamics , and vasoactive eicosanoids .
22374202	0	sodium	133,139	cystic_fibrosis_transmembrane_conductance_regulator	66,117	sodium	cystic fibrosis transmembrane conductance regulator	MESH:D012964	1080	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Effects of rhinovirus_infection on the expression and function of cystic_fibrosis_transmembrane_conductance_regulator and epithelial sodium channel in human nasal mucosa .
2655477	0	sodium	37,43	epidermal_growth_factor	10,33	sodium	epidermal growth factor	MESH:D012964	100008808(Tax:9986)	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|nmod|transport	Effect of epidermal_growth_factor on sodium transport in the cortical collecting tubule .
8031857	0	sodium	54,60	epidermal_growth_factor	21,44	sodium	epidermal growth factor	MESH:D012964	25313(Tax:10116)	Chemical	Gene	cotransport|compound|START_ENTITY effect|nmod|cotransport effect|nmod|END_ENTITY	Short-term effect of epidermal_growth_factor -LRB- EGF -RRB- on sodium and glucose cotransport of isolated jejunal epithelial cells .
17188293	0	sodium	36,42	epidermal_growth_factor_receptor	54,86	sodium	epidermal growth factor receptor	MESH:D012964	100725363	Chemical	Gene	current|compound|START_ENTITY current|nmod|END_ENTITY	Regulation of voltage-gated cardiac sodium current by epidermal_growth_factor_receptor kinase in guinea_pig ventricular myocytes .
21155863	0	sodium	52,58	epidermal_growth_factor_receptor	6,38	sodium	epidermal growth factor receptor	MESH:D012964	1956	Chemical	Gene	homeostasis|compound|START_ENTITY role|nmod|homeostasis END_ENTITY|dep|role	Renal epidermal_growth_factor_receptor : its role in sodium and water homeostasis in diabetic_nephropathy .
22126768	0	sodium	12,18	epithelial_sodium_channel	53,78	sodium	epithelial sodium channel	MESH:D012964	24768(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Effects of sodium on rat osteoblast and the role of epithelial_sodium_channel -RSB- .
8175282	0	sodium	47,53	erythropoietin	29,43	sodium	erythropoietin	MESH:D012964	2056	Chemical	Gene	balance|compound|START_ENTITY END_ENTITY|nmod|balance	Effects of recombinant human erythropoietin on sodium balance in nondialysed children with chronic_renal_failure .
8181200	0	sodium	49,55	erythropoietin	10,24	sodium	erythropoietin	MESH:D012964	2056	Chemical	Gene	load|compound|START_ENTITY Effect|nmod|load Effect|nmod|END_ENTITY	Effect of erythropoietin on renal excretion of a sodium load .
10677232	0	sodium	42,48	factor_Xa	23,32	sodium	factor Xa	MESH:D012964	2159	Chemical	Gene	role|nmod|START_ENTITY site|dep|role site|nmod|END_ENTITY	Sodium binding site of factor_Xa : role of sodium in the prothrombinase complex .
11715834	0	sodium	13,19	factor_Xa	46,55	sodium	factor Xa	MESH:D012964	2159	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	Fondaparinux sodium : a selective inhibitor of factor_Xa .
20580637	0	sodium	53,59	gonadotropin-releasing_hormone	81,111	sodium	gonadotropin-releasing hormone	MESH:D012964	14714(Tax:10090)	Chemical	Gene	currents|compound|START_ENTITY currents|nmod|neurons neurons|amod|END_ENTITY	Estradiol attenuates multiple tetrodotoxin-sensitive sodium currents in isolated gonadotropin-releasing_hormone neurons .
10071455	0	sodium	81,87	granulocyte-colony_stimulating_factor	10,47	sodium	granulocyte-colony stimulating factor	MESH:D012964	1440	Chemical	Gene	therapy|nmod|START_ENTITY Effect|nmod|therapy Effect|nmod|END_ENTITY	Effect of granulocyte-colony_stimulating_factor on empiric therapy with flomoxef sodium and tobramycin in febrile neutropenic patients with hematological_malignancies .
11701449	0	sodium	55,61	growth_hormone	11,25	sodium	growth hormone	MESH:D012964	2688	Chemical	Gene	handling|nmod|START_ENTITY Effects|nmod|handling Effects|nmod|END_ENTITY	Effects of growth_hormone on renal tubular handling of sodium in healthy humans .
1519421	0	sodium	70,76	growth_hormone	28,42	sodium	growth hormone	MESH:D012964	2688	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|dobj|transport	Relationship between plasma growth_hormone concentration and cellular sodium transport in acromegaly .
4828272	0	sodium	28,34	growth_hormone	10,24	sodium	growth hormone	MESH:D012964	2688	Chemical	Gene	transport|compound|START_ENTITY Effect|nmod|transport Effect|nmod|END_ENTITY	Effect of growth_hormone on sodium transport and osmotic water flow across toad skin .
8156731	0	sodium	55,61	growth_hormone	28,42	sodium	growth hormone	MESH:D012964	2688	Chemical	Gene	metabolism|compound|START_ENTITY Effect|nmod|metabolism Effect|nmod|END_ENTITY	Effect of recombinant human growth_hormone on cellular sodium metabolism .
8510517	0	sodium	29,35	growth_hormone	113,127	sodium	growth hormone	MESH:D012964	2688	Chemical	Gene	retention|compound|START_ENTITY Lack|nmod|retention Lack|acl|treated treated|nmod|END_ENTITY	Lack of clinical evidence of sodium retention in children with idiopathic_short_stature treated with recombinant growth_hormone .
8772586	0	sodium	79,85	growth_hormone	11,25	sodium	growth hormone	MESH:D012964	2688	Chemical	Gene	increases|dobj|START_ENTITY increases|nsubj|treatment treatment|compound|END_ENTITY	Short-term growth_hormone -LRB- GH -RRB- treatment of GH-deficient adults increases body sodium and extracellular water , but not blood pressure .
9694949	0	sodium	36,42	growth_hormone	100,114	sodium	growth hormone	MESH:D012964	81668(Tax:10116)	Chemical	Gene	properties|compound|START_ENTITY recovery|nmod|properties treated|nsubj|recovery treated|nmod|END_ENTITY	Partial recovery of skeletal muscle sodium channel properties in aged rats chronically treated with growth_hormone or the GH-secretagogue hexarelin .
10688618	0	sodium	25,31	hH1	21,24	sodium	hH1	MESH:D012964	3009	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dobj|channels	Block of human heart hH1 sodium channels by amitriptyline .
11020758	0	sodium	25,31	hH1	21,24	sodium	hH1	MESH:D012964	3009	Chemical	Gene	channels|compound|START_ENTITY END_ENTITY|dobj|channels	Block of human heart hH1 sodium channels by the enantiomers of bupivacaine .
11160852	0	sodium	40,46	hH1	35,38	sodium	hH1	MESH:D012964	3009	Chemical	Gene	START_ENTITY|nsubj|block block|appos|END_ENTITY	Irreversible block of human heart -LRB- hH1 -RRB- sodium channels by the plant alkaloid lappaconitine .
11891584	0	sodium	48,54	hH1	64,67	sodium	hH1	MESH:D012964	3009	Chemical	Gene	START_ENTITY|dobj|channel channel|appos|END_ENTITY	Functional expression of GFP-linked human heart sodium channel -LRB- hH1 -RRB- and subcellular localization of the a subunit in HEK293 cells and dog cardiac myocytes .
8786355	0	sodium	101,107	hH1	65,68	sodium	hH1	MESH:D012964	3009	Chemical	Gene	channel|compound|START_ENTITY channel|amod|subunit subunit|nmod|cardiac cardiac|appos|END_ENTITY	Functional association of the beta_1 subunit with human cardiac -LRB- hH1 -RRB- and rat skeletal muscle -LRB- mu 1 -RRB- sodium channel alpha subunits expressed in Xenopus oocytes .
10360866	0	sodium	86,92	hH1a	81,85	sodium	hH1a	MESH:D012964	3024	Chemical	Gene	channels|compound|START_ENTITY channels|amod|END_ENTITY	Effects of halothane and isoflurane on fast and slow inactivation of human heart hH1a sodium channels .
8833340	0	sodium	101,107	hSkM1	95,100	sodium	hSkM1	MESH:D012964	6329	Chemical	Gene	gating|compound|START_ENTITY gating|amod|END_ENTITY	Paramyotonia_congenita mutations reveal different roles for segments S3 and S4 of domain D4 in hSkM1 sodium channel gating .
11453434	0	sodium	123,129	inducible_nitric_oxide_synthase	79,110	sodium	inducible nitric oxide synthase	MESH:D012964	24599(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Effect of anti-rat interleukin-6 antibody after spinal_cord_injury in the rat : inducible_nitric_oxide_synthase expression , sodium - and potassium-activated , magnesium-dependent adenosine-5 ' - triphosphatase and superoxide dismutase activation , and ultrastructural changes .
10333344	0	sodium	45,51	insulin	8,15	sodium	insulin	MESH:D012964	3630	Chemical	Gene	sensitivity|compound|START_ENTITY genesis|nmod|sensitivity Role|nmod|genesis Role|nmod|resistance resistance|compound|END_ENTITY	Role of insulin resistance in the genesis of sodium sensitivity in essential hypertension .
10528658	0	sodium	141,147	insulin	97,104	sodium	insulin	MESH:D012964	3630	Chemical	Gene	correlation|compound|START_ENTITY effects|nmod|correlation effects|nsubj|END_ENTITY	Insulin 's acute effects on glomerular filtration rate correlate with insulin_sensitivity whereas insulin 's acute effects on proximal tubular sodium reabsorption correlation with salt sensitivity in normal subjects .
12691602	0	sodium	45,51	insulin	112,119	sodium	insulin	MESH:D012964	3630	Chemical	Gene	restriction|compound|START_ENTITY Decreased_insulin_sensitivity|nmod|restriction mediated|nsubjpass|Decreased_insulin_sensitivity mediated|nmod|effects effects|nmod|angiotensin_II angiotensin_II|nmod|action action|compound|END_ENTITY	Decreased_insulin_sensitivity during dietary sodium restriction is not mediated by effects of angiotensin_II on insulin action .
1363310	0	sodium	44,50	insulin	89,96	sodium	insulin	MESH:D012964	3630	Chemical	Gene	transport|compound|START_ENTITY m-cresol|nmod|transport Potentiation|nmod|m-cresol induced|nsubj|Potentiation induced|nmod|END_ENTITY	Potentiation by m-cresol on transepithelial sodium transport across frog skin induced by insulin .
1425858	0	sodium	38,44	insulin	90,97	sodium	insulin	MESH:D012964	483665(Tax:9615)	Chemical	Gene	insulin|nmod|START_ENTITY role|nmod|insulin Reappraisal|nmod|role Reappraisal|dep|f1fect f1fect|nmod|infusion infusion|compound|END_ENTITY	Reappraisal of the role of insulin on sodium handling by the kidney : f1fect of intrarenal insulin infusion in the dog .
14704836	0	sodium	10,16	insulin	99,106	sodium	insulin	MESH:D012964	3630	Chemical	Gene	intake|compound|START_ENTITY Effect|nmod|intake Effect|dep|role role|nmod|resistance resistance|compound|END_ENTITY	Effect of sodium intake on blood pressure and albuminuria in Type 2 diabetic patients : the role of insulin resistance .
1516724	0	sodium	30,36	insulin	13,20	sodium	insulin	MESH:D012964	3630	Chemical	Gene	handling|compound|START_ENTITY -LSB-|nmod|handling -LSB-|dobj|role role|nmod|END_ENTITY	-LSB- The role of insulin on renal sodium handling and sympathetic nerve activity in overweight normotensive subjects -RSB- .
1730458	0	sodium	28,34	insulin	11,18	sodium	insulin	MESH:D012964	3630	Chemical	Gene	excretion|compound|START_ENTITY Effects|nmod|excretion Effects|nmod|END_ENTITY	Effects of insulin on renal sodium excretion .
17970536	0	sodium	40,46	insulin	54,61	sodium	insulin	MESH:D012964	3630	Chemical	Gene	change|compound|START_ENTITY rich|nmod|change sensitivity|amod|rich sensitivity|compound|END_ENTITY	Does bicarbonated mineral water rich in sodium change insulin sensitivity of postmenopausal women ?
192086	0	sodium	43,49	insulin	11,18	sodium	insulin	MESH:D012964	3630	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|nmod|transport	Effects of insulin , ADH , and cyclic_AMP on sodium transport in the toad bladder .
2065862	0	sodium	27,33	insulin	129,136	sodium	insulin	MESH:D012964	3630	Chemical	Gene	insulin|nmod|START_ENTITY Effect|nmod|insulin Effect|acl|handling handling|nmod|resistance resistance|compound|END_ENTITY	Effect of insulin on renal sodium handling in hyperinsulinaemic_type_2 -LRB- non-insulin-dependent -RRB- diabetic patients with peripheral insulin resistance .
21064417	0	sodium	43,49	insulin	79,86	sodium	insulin	MESH:D012964	3630	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|action action|nmod|END_ENTITY	The effect of pentobarbital_sodium , evipal sodium and demerol on the action of insulin .
2137801	0	sodium	50,56	insulin	8,15	sodium	insulin	MESH:D012964	3630	Chemical	Gene	retention|compound|START_ENTITY peptide|nmod|retention peptide|nsubj|Role Role|nmod|natriuretic natriuretic|compound|END_ENTITY	Role of insulin and atrial natriuretic peptide in sodium retention in insulin-treated IDDM patients during isotonic volume expansion .
22002075	0	sodium	64,70	insulin	11,18	sodium	insulin	MESH:D012964	3630	Chemical	Gene	retention|compound|START_ENTITY handling|nmod|retention insulin|nmod|handling detemir|dobj|insulin detemir|nsubj|Effects Effects|nmod|END_ENTITY	Effects of insulin detemir and NPH insulin on renal handling of sodium , fluid retention and weight in type 2 diabetic patients .
22002075	0	sodium	64,70	insulin	35,42	sodium	insulin	MESH:D012964	3630	Chemical	Gene	retention|compound|START_ENTITY handling|nmod|retention END_ENTITY|nmod|handling	Effects of insulin detemir and NPH insulin on renal handling of sodium , fluid retention and weight in type 2 diabetic patients .
2441907	0	sodium	14,20	insulin	76,83	sodium	insulin	MESH:D012964	3630	Chemical	Gene	pump|compound|START_ENTITY pump|dep|association association|nmod|END_ENTITY	The leucocyte sodium pump in healthy and obese subjects : the association of insulin with its activity .
2455613	0	sodium	42,48	insulin	19,26	sodium	insulin	MESH:D012964	3630	Chemical	Gene	mechanisms|compound|START_ENTITY END_ENTITY|nmod|mechanisms	In vitro action of insulin on erythrocyte sodium transport mechanisms : its possible role in the pathogenesis of arterial hypertension .
6113218	0	sodium	37,43	insulin	13,20	sodium	insulin	MESH:D012964	3630	Chemical	Gene	balance|compound|START_ENTITY Influence|nmod|balance Influence|nmod|END_ENTITY	Influence of insulin and glucagon on sodium balance in obese subjects during fasting and refeeding .
7007090	0	sodium	62,68	insulin	11,18	sodium	insulin	MESH:D012964	396145(Tax:9031)	Chemical	Gene	ions|compound|START_ENTITY concentration|nmod|ions END_ENTITY|nmod|concentration	-LSB- Effect of insulin and hydrocortisone on the concentration of sodium and potassium ions in nucleated and non-nucleated erythrocytes of chickens and rats -RSB- .
7028550	0	sodium	31,37	insulin	14,21	sodium	insulin	MESH:D012964	3630	Chemical	Gene	metabolism|compound|START_ENTITY effect|nmod|metabolism effect|nmod|END_ENTITY	The effect of insulin on renal sodium metabolism .
7702805	0	sodium	112,118	insulin	10,17	sodium	insulin	MESH:D012964	3630	Chemical	Gene	status|compound|START_ENTITY influence|nmod|status Effect|dep|influence Effect|nmod|END_ENTITY	Effect of insulin on the venoconstrictive response to norepinephrine in normal human subjects : the influence of sodium status .
8060573	0	sodium	21,27	insulin	10,17	sodium	insulin	MESH:D012964	3630	Chemical	Gene	reabsorption|compound|START_ENTITY Effect|nmod|reabsorption Effect|nmod|END_ENTITY	Effect of insulin on sodium reabsorption in hypertensive patients .
8141170	0	sodium	20,26	insulin	42,49	sodium	insulin	MESH:D012964	3630	Chemical	Gene	sensitivity|compound|START_ENTITY relationship|nmod|sensitivity relationship|nmod|resistance resistance|compound|END_ENTITY	The relationship of sodium sensitivity to insulin resistance .
8200182	0	sodium	51,57	insulin	22,29	sodium	insulin	MESH:D012964	3630	Chemical	Gene	suppression|nmod|START_ENTITY suppression|compound|END_ENTITY	Effects of short-time insulin suppression on renal sodium excretion in type_II_diabetic_hypertensives .
8282372	0	sodium	56,62	insulin	39,46	sodium	insulin	MESH:D012964	3630	Chemical	Gene	handling|compound|START_ENTITY sensitivity|nmod|handling sensitivity|nmod|END_ENTITY	Insulin sensitivity and the effects of insulin on renal sodium handling and pressor systems in essential hypertensive patients .
9324100	0	sodium	18,24	insulin	28,35	sodium	insulin	MESH:D012964	3630	Chemical	Gene	START_ENTITY|nmod|sensitivity sensitivity|compound|END_ENTITY	Effect of dietary sodium on insulin sensitivity in older , obese , sedentary hypertensives .
9703338	0	sodium	45,51	insulin	100,107	sodium	insulin	MESH:D012964	3630	Chemical	Gene	intake|compound|START_ENTITY pressure|nmod|intake responsiveness|nmod|pressure associated|nsubjpass|responsiveness associated|nmod|resistance resistance|compound|END_ENTITY	Enhanced responsiveness of blood pressure to sodium intake and to angiotensin_II is associated with insulin resistance in IDDM patients with microalbuminuria .
18424559	0	sodium	9,15	insulin_receptor	106,122	sodium	insulin receptor	MESH:D012964	16337(Tax:10090)	Chemical	Gene	excretion|compound|START_ENTITY excretion|nmod|END_ENTITY	Impaired sodium excretion and increased blood pressure in mice with targeted deletion of renal epithelial insulin_receptor .
10705301	0	sodium	88,94	interferon-gamma	23,39	sodium	interferon-gamma	MESH:D012964	15978(Tax:10090)	Chemical	Gene	increases|nmod|START_ENTITY increases|nsubj|END_ENTITY	Interleukin-12 induced interferon-gamma increases inflammation in acute dextran sulfate sodium induced colitis in mice .
3084468	0	sodium	58,64	interleukin-1	10,23	sodium	interleukin-1	MESH:D012964	111343(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|concentration concentration|amod|END_ENTITY	Effect of interleukin-1 on intracellular concentration of sodium , calcium , and potassium in 70Z/3 cells .
26437894	0	sodium	53,59	interleukin-33	21,35	sodium	interleukin-33	MESH:D012964	90865	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	A potential role for interleukin-33 and y-epithelium sodium channel in the pathogenesis of human malaria associated lung_injury .
6919568	0	sodium	26,32	kallikrein	90,100	sodium	kallikrein	MESH:D012964	9622	Chemical	Gene	Effects|nmod|START_ENTITY Effects|acl|END_ENTITY	Effects of restriction of sodium or administration of fludrocortisone on parotid salivary kallikrein in man .
10770960	0	sodium	49,55	mCAP1	87,92	sodium	mCAP1	MESH:D012964	12331(Tax:10090)	Chemical	Gene	channel|compound|START_ENTITY channel|nmod|END_ENTITY	Activation of the amiloride-sensitive epithelial sodium channel by the serine_protease mCAP1 expressed in a mouse cortical collecting duct cell line .
25415435	0	sodium	30,36	mTORC2	0,6	sodium	mTORC2	MESH:D012964	74343(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY regulates|dobj|uptake regulates|nsubj|END_ENTITY	mTORC2 regulates renal tubule sodium uptake by promoting ENaC activity .
1660285	0	sodium	73,79	microI	66,72	sodium	microI	MESH:D012964	25722(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY channel|amod|END_ENTITY	Multiple gating modes and the effect of modulating factors on the microI sodium channel .
10784102	0	sodium	63,69	nerve_growth_factor	20,39	sodium	nerve growth factor	MESH:D012964	310738(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY augmentation|nmod|channels role|nmod|augmentation role|nmod|END_ENTITY	A possible role for nerve_growth_factor in the augmentation of sodium channels in models of chronic_pain .
2159518	0	sodium	20,26	nerve_growth_factor	120,139	sodium	nerve growth factor	MESH:D012964	4803	Chemical	Gene	currents|compound|START_ENTITY Characterization|nmod|currents cultured|nsubj|Characterization cultured|nmod|END_ENTITY	Characterization of sodium currents in mammalian sensory neurons cultured in serum-free defined medium with and without nerve_growth_factor .
2435307	0	sodium	56,62	nerve_growth_factor	14,33	sodium	nerve growth factor	MESH:D012964	310738(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY development|nmod|channels effect|nmod|development effect|nmod|END_ENTITY	The effect of nerve_growth_factor on the development of sodium channels in PC12 cells .
7407562	0	sodium	56,62	nerve_growth_factor	15,34	sodium	nerve growth factor	MESH:D012964	396466(Tax:9031)	Chemical	Gene	environment|compound|START_ENTITY END_ENTITY|nmod|environment	Maintenance by nerve_growth_factor of the intracellular sodium environment in spinal sensory and sympathetic ganglionic cells .
7695907	0	sodium	87,93	nerve_growth_factor	18,37	sodium	nerve growth factor	MESH:D012964	310738(Tax:10116)	Chemical	Gene	induction|compound|START_ENTITY triggers|nmod|induction triggers|nsubj|pulse pulse|nmod|END_ENTITY	A single pulse of nerve_growth_factor triggers long-term neuronal excitability through sodium channel gene induction .
9582237	0	sodium	20,26	nerve_growth_factor	101,120	sodium	nerve growth factor	MESH:D012964	4803	Chemical	Gene	expression|compound|START_ENTITY Rescue|nmod|expression root|nsubj|Rescue root|nmod|END_ENTITY	Rescue of alpha-SNS sodium channel expression in small dorsal root ganglion neurons after axotomy by nerve_growth_factor in vivo .
2905268	0	sodium	70,76	neuropeptide_Y	21,35	sodium	neuropeptide Y	MESH:D012964	24604(Tax:10116)	Chemical	Gene	excretion|nmod|START_ENTITY effects|nmod|excretion effects|nmod|END_ENTITY	Disparate effects of neuropeptide_Y and clonidine on the excretion of sodium and water in the rat .
12040042	0	sodium	42,48	para	23,27	sodium	para	MESH:D012964	32619(Tax:7227)	Chemical	Gene	channel|compound|START_ENTITY channel|compound|END_ENTITY	Domain 2 of Drosophila para voltage-gated sodium channel confers insect properties to a rat brain channel .
25371524	0	sodium	12,18	parathyroid_hormone	75,94	sodium	parathyroid hormone	MESH:D012964	24694(Tax:10116)	Chemical	Gene	retention|compound|START_ENTITY Dynamics|nmod|retention assessed|nsubj|Dynamics assessed|nmod|injection injection|amod|END_ENTITY	Dynamics of sodium retention in preascitic cirrhotic rats assessed through parathyroid_hormone injection .
2994494	0	sodium	77,83	parathyroid_hormone	19,38	sodium	parathyroid hormone	MESH:D012964	100351309(Tax:9986)	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|nmod|transport	Relationship among parathyroid_hormone , cAMP , and calcium on proximal tubule sodium transport .
971575	0	sodium	34,40	parathyroid_hormone	11,30	sodium	parathyroid hormone	MESH:D012964	403986(Tax:9615)	Chemical	Gene	transport|compound|START_ENTITY Effects|nmod|transport Effects|nmod|END_ENTITY	Effects of parathyroid_hormone on sodium and calcium transport in the dog nephron .
17272351	0	sodium	19,25	preB	43,47	sodium	preB	MESH:D012964	50907(Tax:10090)	Chemical	Gene	current|compound|START_ENTITY current|nmod|END_ENTITY	Role of persistent sodium current in mouse preB tzinger Complex neurons and respiratory rhythm generation .
25963375	0	sodium	16,22	prion_protein	71,84	sodium	prion protein	MESH:D012964	5621	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Dextran sulfate sodium inhibits amyloid-b oligomer binding to cellular prion_protein .
1036731	0	sodium	61,67	prolactin	24,33	sodium	prolactin	MESH:D012964	5617	Chemical	Gene	suppression|nmod|START_ENTITY suppression|compound|END_ENTITY	Lack of effect of acute prolactin suppression on renal water sodium and potassium excretion during sleep .
17257	0	sodium	78,84	prolactin	16,25	sodium	prolactin	MESH:D012964	5617	Chemical	Gene	correlation|nmod|START_ENTITY END_ENTITY|dep|correlation	Increased serum prolactin in diabetic_ketoacidosis ; correlation between serum sodium and serum prolacting concentration .
578621	0	sodium	11,17	prolactin	57,66	sodium	prolactin	MESH:D012964	24683(Tax:10116)	Chemical	Gene	loading|compound|START_ENTITY Failure|nmod|loading Failure|acl|affect affect|dobj|END_ENTITY	Failure of sodium loading or deficiency to affect plasma prolactin in the male rat .
6258970	0	sodium	38,44	prolactin	10,19	sodium	prolactin	MESH:D012964	5617	Chemical	Gene	transport|compound|START_ENTITY Effect|nmod|transport Effect|nmod|END_ENTITY	Effect of prolactin on human red cell sodium transport .
23344129	0	sodium	107,113	prostasin	8,17	sodium	prostasin	MESH:D012964	5652	Chemical	Gene	correlation|nmod|START_ENTITY END_ENTITY|dep|correlation	Urinary prostasin in normotensive individuals : correlation with the aldosterone to renin ratio and urinary sodium .
10792624	0	sodium	26,32	rBSC1	58,63	sodium	rBSC1	MESH:D012964	25065(Tax:10116)	Chemical	Gene	transcripts|compound|START_ENTITY transcripts|appos|END_ENTITY	Cardiac_infarcts increase sodium transporter transcripts -LRB- rBSC1 -RRB- in the thick ascending limb of Henle .
12629269	0	sodium	55,61	rBSC1	77,82	sodium	rBSC1	MESH:D012964	25065(Tax:10116)	Chemical	Gene	cotransporter|compound|START_ENTITY cotransporter|appos|END_ENTITY	Urinary concentration defect and limited expression of sodium cotransporter , rBSC1 , in a rat model of chronic_renal_failure .
9649383	0	sodium	86,92	rSkM1	102,107	sodium	rSkM1	MESH:D012964	25722(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY channel|appos|END_ENTITY	Extrapore residues of the S5-S6 loop of domain 2 of the voltage-gated skeletal muscle sodium channel -LRB- rSkM1 -RRB- contribute to the mu-conotoxin GIIIA binding site .
2610088	0	sodium	53,59	renal_kallikrein	8,24	sodium	renal kallikrein	MESH:D012964	24523(Tax:10116)	Chemical	Gene	excretion|compound|START_ENTITY END_ENTITY|nmod|excretion	Role of renal_kallikrein in the increased fractional sodium excretion in the rat remnant kidney model of chronic_renal_failure .
1011955	0	sodium	17,23	renin	56,61	sodium	renin	MESH:D012964	5972	Chemical	Gene	conservation|compound|START_ENTITY conservation|dep|changes changes|nmod|END_ENTITY	Exercise induced sodium conservation : changes in plasma renin and aldosterone .
10444563	0	sodium	45,51	renin	19,24	sodium	renin	MESH:D012964	403838(Tax:9615)	Chemical	Gene	intake|compound|START_ENTITY effects|nmod|intake release|dep|effects release|compound|END_ENTITY	Pressure-dependent renin release : effects of sodium intake and changes of total_body_sodium .
10725	0	sodium	10,16	renin	37,42	sodium	renin	MESH:D012964	5972	Chemical	Gene	depletion|compound|START_ENTITY depletion|nmod|END_ENTITY	Effect of sodium depletion on plasma renin concentration before and during adrenergic beta-receptor blockade with propranolol in normotensive man .
1077763	0	sodium	22,28	renin	7,12	sodium	renin	MESH:D012964	5972	Chemical	Gene	excretion|compound|START_ENTITY END_ENTITY|appos|excretion	Plasma renin , urinary sodium excretion and vascular_disease .
11211621	0	sodium	13,19	renin	56,61	sodium	renin	MESH:D012964	5972	Chemical	Gene	intake|compound|START_ENTITY Influence|nmod|intake Influence|nmod|reliability reliability|nmod|END_ENTITY	Influence of sodium intake on the reliability of active renin as a measure of the renin-angiotensin system in essential hypertension .
1135521	0	sodium	63,69	renin	27,32	sodium	renin	MESH:D012964	5972	Chemical	Gene	conservation|compound|START_ENTITY activity|nmod|conservation activity|compound|END_ENTITY	Marked elevation of plasma renin activity during post diuretic sodium conservation in furosemide stimulated subjects .
11446717	0	sodium	76,82	renin	43,48	sodium	renin	MESH:D012964	24715(Tax:10116)	Chemical	Gene	synthesis|nmod|START_ENTITY synthesis|compound|END_ENTITY	Role_of_the_renal_nerves in the control of renin synthesis during different sodium intakes in the rat .
1145199	0	sodium	39,45	renin	17,22	sodium	renin	MESH:D012964	24715(Tax:10116)	Chemical	Gene	dependency|compound|START_ENTITY dependency|nmod|dependency dependency|nsubj|Reciprocation Reciprocation|nmod|END_ENTITY	Reciprocation of renin dependency with sodium volume dependency in renal hypertension .
1149405	0	sodium	32,38	renin	101,106	sodium	renin	MESH:D012964	5972	Chemical	Gene	handling|compound|START_ENTITY progesterone|nmod|handling Effect|nmod|progesterone Effect|dep|relation relation|acl|aldosterone aldosterone|dobj|activity activity|compound|END_ENTITY	Effect of progesterone on renal sodium handling in man : relation to aldosterone excretion and plasma renin activity .
11719734	0	sodium	4,10	renin	53,58	sodium	renin	MESH:D012964	5972	Chemical	Gene	START_ENTITY|nmod|system system|compound|END_ENTITY	Low sodium and furosemide-induced stimulation of the renin system in man is mediated by cyclooxygenase_2 .
12413503	0	sodium	17,23	renin	69,74	sodium	renin	MESH:D012964	5972	Chemical	Gene	ratio|compound|START_ENTITY Serum|nmod|ratio estimate|nsubj|Serum estimate|nmod|activity activity|compound|END_ENTITY	Serum to urinary sodium concentration ratio is an estimate of plasma renin activity in congestive_heart_failure .
1269103	0	sodium	23,29	renin	65,70	sodium	renin	MESH:D012964	24715(Tax:10116)	Chemical	Gene	balance|compound|START_ENTITY balance|nmod|release release|compound|END_ENTITY	The effects of altered sodium balance and adrenergic blockade on renin release induced in rats by angiotensin antagonism .
1307720	0	sodium	113,119	renin	82,87	sodium	renin	MESH:D012964	24715(Tax:10116)	Chemical	Gene	depletion|compound|START_ENTITY effect|nmod|depletion distribution|dep|effect distribution|nmod|forms forms|nmod|END_ENTITY	Subcellular distribution of differently glycosylated forms of active and inactive renin in rat kidney : effect of sodium depletion and captopril treatment .
1482638	0	sodium	60,66	renin	7,12	sodium	renin	MESH:D012964	24715(Tax:10116)	Chemical	Gene	deficiency|compound|START_ENTITY due|nmod|deficiency END_ENTITY|xcomp|due	Plasma renin activity as a marker for growth_failure due to sodium deficiency in young rats .
148727	0	sodium	27,33	renin	43,48	sodium	renin	MESH:D012964	5972	Chemical	Gene	loads|compound|START_ENTITY loads|nmod|END_ENTITY	The influence of different sodium loads on renin release in hypertensive and normotensive states of chronic_renal_failure .
1590429	0	sodium	71,77	renin	20,25	sodium	renin	MESH:D012964	5972	Chemical	Gene	balance|compound|START_ENTITY effects|nmod|balance pattern|dep|effects pattern|nmod|secretion secretion|compound|END_ENTITY	Temporal pattern of renin and aldosterone secretion in men : effects of sodium balance .
166090	0	sodium	11,17	renin	38,43	sodium	renin	MESH:D012964	5972	Chemical	Gene	depletion|compound|START_ENTITY Effects|nmod|depletion Effects|nmod|activity activity|compound|END_ENTITY	Effects of sodium depletion on plasma renin activity and on the urinary excretion of cyclic_AMP and aldosterone in hypoparathyroid patients .
1706037	0	sodium	25,31	renin	63,68	sodium	renin	MESH:D012964	5972	Chemical	Gene	sensitivity|compound|START_ENTITY sensitivity|nmod|hypertension hypertension|compound|END_ENTITY	Phosphate as a factor in sodium sensitivity in normal and high renin hypertension .
1708028	0	sodium	20,26	renin	53,58	sodium	renin	MESH:D012964	24715(Tax:10116)	Chemical	Gene	appetite|appos|START_ENTITY appetite|appos|rats rats|compound|END_ENTITY	Salt appetite , body sodium , handling of a NaCl load , renin , and aldosterone in genetically and spontaneously hypertensive rats .
17989136	0	sodium	70,76	renin	29,34	sodium	renin	MESH:D012964	5972	Chemical	Gene	related|nmod|START_ENTITY related|nsubjpass|activation activation|nmod|END_ENTITY	Chronic activation of plasma renin is log-linearly related to dietary sodium and eliminates natriuresis in response to a pulse change in total_body_sodium .
1830843	0	sodium	14,20	renin	69,74	sodium	renin	MESH:D012964	5972	Chemical	Gene	handling|compound|START_ENTITY atrial|nsubj|handling atrial|dobj|men men|compound|activity activity|amod|END_ENTITY	Renal tubular sodium handling and plasma atrial natriuretic peptide , renin activity and aldosterone in untreated men under normal living conditions .
1840285	0	sodium	108,114	renin	70,75	sodium	renin	MESH:D012964	24715(Tax:10116)	Chemical	Gene	loading|compound|START_ENTITY activity|nmod|loading activity|compound|END_ENTITY	Renal_excretory_function , atrial_natriuretic_peptide -LRB- ANP -RRB- and plasma renin activity -LRB- PRA -RRB- during long-term sodium loading in rats .
186664	2	sodium	295,301	renin	346,351	sodium	renin	MESH:D012964	24715(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY decrease|nmod|levels had|dobj|decrease had|nmod|increase increase|nmod|granules granules|compound|END_ENTITY	Animals on a sodium-deficient diet had a significant decrease of serum sodium levels with a concomitant increase of renal renin granules .
19073901	0	sodium	13,19	renin	57,62	sodium	renin	MESH:D012964	5972	Chemical	Gene	loading|compound|START_ENTITY loading|dep|regulation regulation|nmod|secretion secretion|compound|END_ENTITY	Normotensive sodium loading in normal man : regulation of renin secretion during beta-receptor blockade .
19073902	0	sodium	13,19	renin	61,66	sodium	renin	MESH:D012964	403838(Tax:9615)	Chemical	Gene	loading|compound|START_ENTITY loading|dep|regulation regulation|nmod|secretion secretion|compound|END_ENTITY	Normotensive sodium loading in conscious dogs : regulation of renin secretion during beta-receptor blockade .
1914196	0	sodium	9,15	renin	60,65	sodium	renin	MESH:D012964	5972	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|appos|secretion secretion|compound|END_ENTITY	Abnormal sodium metabolism and plasma renin activity -LRB- renal renin secretion -RRB- and the vasoconstriction volume hypothesis : implications for pathogenesis and treatment of hypertension and its vascular consequences -LRB- heart_attack , stroke -RRB- .
1977841	0	sodium	10,16	renin	37,42	sodium	renin	MESH:D012964	5972	Chemical	Gene	depletion|compound|START_ENTITY depletion|nmod|END_ENTITY	Effect of sodium depletion on active renin , inactive renin and prekallikrein in plasma and urinary kallikrein excretion in glomerulonephritic patients .
1977841	0	sodium	10,16	renin	53,58	sodium	renin	MESH:D012964	5972	Chemical	Gene	depletion|compound|START_ENTITY Effect|nmod|depletion inactive|nsubj|Effect inactive|dobj|END_ENTITY	Effect of sodium depletion on active renin , inactive renin and prekallikrein in plasma and urinary kallikrein excretion in glomerulonephritic patients .
21282553	0	sodium	124,130	renin	26,31	sodium	renin	MESH:D012964	24715(Tax:10116)	Chemical	Gene	channel|compound|START_ENTITY kinase|nmod|channel cells|nmod|kinase collecting|dobj|cells medullary|acl|collecting stimulates|nmod|medullary stimulates|dobj|END_ENTITY	Angiotensin_II stimulates renin in inner medullary collecting duct cells via protein kinase C and independent of epithelial sodium channel and mineralocorticoid receptor activity .
21330422	0	sodium	97,103	renin	46,51	sodium	renin	MESH:D012964	5972	Chemical	Gene	intake|compound|START_ENTITY associated|nmod|intake associated|nmod|activity activity|compound|END_ENTITY	25-Hydroxyvitamin_D is associated with plasma renin activity and the pressor response to dietary sodium intake in Caucasians .
215928	0	sodium	107,113	renin	28,33	sodium	renin	MESH:D012964	24715(Tax:10116)	Chemical	Gene	deficiency|compound|START_ENTITY modification|nmod|deficiency Effect|dep|modification Effect|nmod|norepinephrine norepinephrine|nmod|release release|compound|END_ENTITY	Effect of norepinephrine on renin release and the cyclic_AMP content of rat kidney slices : modification by sodium deficiency and alpha-adrenergic blockade .
2175824	0	sodium	128,134	renin	94,99	sodium	renin	MESH:D012964	24715(Tax:10116)	Chemical	Gene	diet|compound|START_ENTITY produced|nmod|diet produced|nsubj|evidence evidence|nmod|involvement involvement|nmod|system system|nmod|increase increase|nmod|secretion secretion|compound|END_ENTITY	Pharmacological evidence for involvement of the sympathetic nervous system in the increase in renin secretion produced by a low sodium diet in rats .
218749	0	sodium	117,123	renin	20,25	sodium	renin	MESH:D012964	5972	Chemical	Gene	retention|compound|START_ENTITY independence|nmod|retention Reduction|dep|independence Reduction|nmod|activity activity|compound|END_ENTITY	Reduction of plasma renin activity by inhibition of the fatty_acid cyclooxygenase in human subjects : independence of sodium retention .
22071811	0	sodium	15,21	renin	70,75	sodium	renin	MESH:D012964	5972	Chemical	Gene	diet|compound|START_ENTITY Effects|nmod|diet Effects|nmod|diet diet|nmod|pressure pressure|appos|END_ENTITY	Effects of low sodium diet versus high sodium diet on blood pressure , renin , aldosterone , catecholamines , cholesterol , and triglyceride .
22071811	0	sodium	39,45	renin	70,75	sodium	renin	MESH:D012964	5972	Chemical	Gene	diet|compound|START_ENTITY diet|nmod|pressure pressure|appos|END_ENTITY	Effects of low sodium diet versus high sodium diet on blood pressure , renin , aldosterone , catecholamines , cholesterol , and triglyceride .
227278	0	sodium	10,16	renin	39,44	sodium	renin	MESH:D012964	24715(Tax:10116)	Chemical	Gene	restriction|compound|START_ENTITY Effect|nmod|restriction Effect|nmod|activity activity|compound|END_ENTITY	Effect of sodium restriction on plasma renin activity and renin granules in rat kidney .
23344129	0	sodium	107,113	renin	83,88	sodium	renin	MESH:D012964	5972	Chemical	Gene	START_ENTITY|amod|aldosterone aldosterone|nmod|ratio ratio|compound|END_ENTITY	Urinary prostasin in normotensive individuals : correlation with the aldosterone to renin ratio and urinary sodium .
24622156	0	sodium	56,62	renin	23,28	sodium	renin	MESH:D012964	5972	Chemical	Gene	intervention|compound|START_ENTITY dietary|dobj|intervention response|acl|dietary response|nmod|END_ENTITY	The unique response of renin and aldosterone to dietary sodium intervention in sodium sensitivity .
24622156	0	sodium	79,85	renin	23,28	sodium	renin	MESH:D012964	5972	Chemical	Gene	sensitivity|compound|START_ENTITY dietary|nmod|sensitivity response|acl|dietary response|nmod|END_ENTITY	The unique response of renin and aldosterone to dietary sodium intervention in sodium sensitivity .
25043079	0	sodium	38,44	renin	56,61	sodium	renin	MESH:D012964	5972	Chemical	Gene	removal|compound|START_ENTITY removal|nmod|END_ENTITY	Effects of mildly increasing dialysis sodium removal on renin and sympathetic system in hemodialysis patients .
2544099	0	sodium	43,49	renin	22,27	sodium	renin	MESH:D012964	403838(Tax:9615)	Chemical	Gene	deprivation|compound|START_ENTITY control|nmod|deprivation control|nmod|END_ENTITY	Adrenergic control of renin during dietary sodium deprivation in conscious dogs .
2645917	0	sodium	54,60	renin	76,81	sodium	renin	MESH:D012964	5972	Chemical	Gene	intake|compound|START_ENTITY responses|nmod|intake pressure|dobj|responses pressure|nmod|hypertension hypertension|compound|END_ENTITY	Blood pressure and serum calcium responses to altered sodium intake in high renin hypertension .
2651649	0	sodium	52,58	renin	31,36	sodium	renin	MESH:D012964	24715(Tax:10116)	Chemical	Gene	restriction|compound|START_ENTITY adenosine|nmod|restriction adenosine|dobj|release release|compound|END_ENTITY	Endogenous adenosine restrains renin release during sodium restriction .
2677137	6	sodium	712,718	renin	796,801	sodium	renin	MESH:D012964	24715(Tax:10116)	Chemical	Gene	depletion|compound|START_ENTITY caused|nsubj|depletion caused|nmod|mRNA mRNA|compound|END_ENTITY	Both sodium depletion and captopril treatment caused significant increases in the kidney renin mRNA in SHR and WKY .
2677374	0	sodium	73,79	renin	43,48	sodium	renin	MESH:D012964	5972	Chemical	Gene	man|compound|START_ENTITY H142|nmod|man hypotension|nmod|H142 hypotension|nmod|inhibition inhibition|compound|END_ENTITY	Severe hypotension with bradycardia during renin inhibition with H142 in sodium deplete man .
2856715	0	sodium	14,20	renin	35,40	sodium	renin	MESH:D012964	24715(Tax:10116)	Chemical	Gene	intake|compound|START_ENTITY intake|nmod|response response|compound|END_ENTITY	The effect of sodium intake on the renin response to dopamine in superfused rat renal cortical cells .
2870870	0	sodium	66,72	renin	35,40	sodium	renin	MESH:D012964	24715(Tax:10116)	Chemical	Gene	pressure|nmod|START_ENTITY pressure|aux|END_ENTITY	Effect of elevated blood pressure , renin and aldosterone on renal sodium handling in two-kidney Goldblatt hypertensive rats .
2977165	0	sodium	21,27	renin	39,44	sodium	renin	MESH:D012964	24715(Tax:10116)	Chemical	Gene	balance|compound|START_ENTITY changes|nmod|balance Effect|nmod|changes Effect|nmod|levels levels|compound|END_ENTITY	Effect of changes in sodium balance on renin , angiotensinogen and atrial_natriuretic_factor messenger RNA levels in rats .
3045293	0	sodium	10,16	renin	35,40	sodium	renin	MESH:D012964	24715(Tax:10116)	Chemical	Gene	intake|compound|START_ENTITY Effect|nmod|intake Effect|nmod|excretion excretion|compound|END_ENTITY	Effect of sodium intake on urinary renin excretion in rats .
3524919	0	sodium	10,16	renin	73,78	sodium	renin	MESH:D012964	24715(Tax:10116)	Chemical	Gene	intake|compound|START_ENTITY Effect|nmod|intake Effect|nmod|content content|compound|END_ENTITY	Effect of sodium intake and sodium delivery to the macula densa on renal renin content and juxtaglomerular apparatus morphology .
3529827	0	sodium	14,20	renin	69,74	sodium	renin	MESH:D012964	24715(Tax:10116)	Chemical	Gene	load|compound|START_ENTITY effect|nmod|load effect|nmod|development development|nmod|END_ENTITY	The effect of sodium load on the development of hypertension , plasma renin and kininogen in rats with renal_artery_constriction .
3903529	0	sodium	106,112	renin	53,58	sodium	renin	MESH:D012964	5972	Chemical	Gene	diet|compound|START_ENTITY men|nmod|diet inhibit|nmod|men inhibit|dobj|release release|compound|END_ENTITY	Sulindac and ibuprofen inhibit furosemide-stimulated renin release but not natriuresis in men on a normal sodium diet .
396613	0	sodium	10,16	renin	35,40	sodium	renin	MESH:D012964	24715(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of sodium and osmolarity on renin secretion .
397714	4	sodium	749,755	renin	673,678	sodium	renin	MESH:D012964	5972	Chemical	Gene	intake|compound|START_ENTITY increasing|dobj|intake normalized|advcl|increasing normalized|nsubj|values values|nmod|activity activity|compound|END_ENTITY	Moderately elevated values of plasma renin activity in older salt-losers normalized after increasing the dietary sodium intake .
398992	0	sodium	63,69	renin	54,59	sodium	renin	MESH:D012964	5972	Chemical	Gene	balance|compound|START_ENTITY END_ENTITY|nmod|balance	The relationship of urinary prostaglandins and plasma renin to sodium balance and diuresis in normal man .
429871	0	sodium	29,35	renin	53,58	sodium	renin	MESH:D012964	5972	Chemical	Gene	intake|compound|START_ENTITY effect|nmod|intake effect|nmod|activity activity|compound|END_ENTITY	The effect of extremely high sodium intake on plasma renin activity , plasma aldosterone concentration , and urinary_excretion_of_aldosterone_metabolites .
4317794	0	sodium	22,28	renin	77,82	sodium	renin	MESH:D012964	403838(Tax:9615)	Chemical	Gene	concentration|compound|START_ENTITY effect|nmod|concentration effect|nmod|release release|compound|END_ENTITY	The effect of altered sodium concentration in the distal nephron segments on renin release .
481942	0	sodium	33,39	renin	7,12	sodium	renin	MESH:D012964	5972	Chemical	Gene	balance|compound|START_ENTITY related|nmod|balance related|nsubj|activity activity|compound|END_ENTITY	Plasma renin activity related to sodium balance , renal function and urinary vasopressin in the newborn infant .
490374	0	sodium	66,72	renin	27,32	sodium	renin	MESH:D012964	100358545(Tax:9986)	Chemical	Gene	depletion|compound|START_ENTITY effect|nmod|depletion END_ENTITY|dep|effect	Plasma active and inactive renin in the rabbit : effect of dietary sodium depletion and repletion .
5107275	0	sodium	14,20	renin	53,58	sodium	renin	MESH:D012964	5972	Chemical	Gene	concentration|compound|START_ENTITY concentration|nmod|release release|nmod|END_ENTITY	-LSB- Influence of sodium concentration on the release of renin from kidney cortex slices and isolated glomeruli -RSB- .
513492	0	sodium	84,90	renin	39,44	sodium	renin	MESH:D012964	5972	Chemical	Gene	restriction|compound|START_ENTITY aldosterone|nmod|restriction aldosterone|nsubj|Effect Effect|nmod|activity activity|amod|potassium_chloride potassium_chloride|nmod|END_ENTITY	Effect of potassium_chloride on plasma renin activity and plasma aldosterone during sodium restriction in normal man .
5142557	0	sodium	10,16	renin	46,51	sodium	renin	MESH:D012964	5972	Chemical	Gene	concentration|compound|START_ENTITY concentration|nmod|END_ENTITY	Effect of sodium and osmotic concentration on renin release by renal cortical slices in vitro .
5655612	0	sodium	14,20	renin	30,35	sodium	renin	MESH:D012964	5972	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of sodium on renal renin and on glucose-6-phosphate_dehydrogenase in the kidneys , salivary glands and adrenal glands .
583038	0	sodium	83,89	renin	7,12	sodium	renin	MESH:D012964	5972	Chemical	Gene	intakes|compound|START_ENTITY infants|nmod|intakes concentration|nmod|infants END_ENTITY|dobj|concentration	Plasma renin activity and plasma aldosterone concentration in infants with various sodium intakes .
6128546	0	sodium	64,70	renin	44,49	sodium	renin	MESH:D012964	5972	Chemical	Gene	retention|compound|START_ENTITY causes|dobj|retention causes|nsubj|mechanism mechanism|nmod|system system|compound|END_ENTITY	Evidence that some mechanism other than the renin system causes sodium retention in nephrotic_syndrome .
6159648	0	sodium	70,76	renin	23,28	sodium	renin	MESH:D012964	5972	Chemical	Gene	depletion|compound|START_ENTITY studies|nmod|depletion inhibition|dep|studies inhibition|nmod|END_ENTITY	Specific inhibition of renin by an angiotensinogen analog : studies in sodium depletion and renin-dependent hypertension .
6206557	0	sodium	31,37	renin	22,27	sodium	renin	MESH:D012964	24715(Tax:10116)	Chemical	Gene	depleted|compound|START_ENTITY inhibition|nmod|depleted inhibition|nmod|END_ENTITY	The inhibition of rat renin in sodium depleted and renal hypertensive rats .
6355550	0	sodium	49,55	renin	85,90	sodium	renin	MESH:D012964	5972	Chemical	Gene	metabolism|compound|START_ENTITY system|nmod|metabolism role|nmod|system role|nmod|hypertension hypertension|amod|END_ENTITY	The role of the renal kallikrein-kinin system in sodium metabolism in normal and low renin essential hypertension .
6360871	1	sodium	110,116	renin	75,80	sodium	renin	MESH:D012964	24715(Tax:10116)	Chemical	Gene	intake|compound|START_ENTITY variations|nmod|intake END_ENTITY|nmod|variations	Effect on urinary prostaglandin_E2 and plasma renin in response to variations in sodium intake and in relation to blood pressure .
6373592	0	sodium	21,27	renin	78,83	sodium	renin	MESH:D012964	24715(Tax:10116)	Chemical	Gene	balance|compound|START_ENTITY changes|nmod|balance Effect|nmod|changes nephrectomy|nsubj|Effect nephrectomy|nmod|END_ENTITY	Effect of changes in sodium or potassium balance , and nephrectomy , on adrenal renin and aldosterone concentrations .
6376345	0	sodium	11,17	renin	51,56	sodium	renin	MESH:D012964	403838(Tax:9615)	Chemical	Gene	depletion|compound|START_ENTITY Effects|nmod|depletion Effects|nmod|END_ENTITY	Effects of sodium depletion on inactive and active renin from dog kidney and plasma .
6382488	0	sodium	112,118	renin	21,26	sodium	renin	MESH:D012964	5972	Chemical	Gene	intake|compound|START_ENTITY Expression|nmod|intake Expression|nmod|activity activity|compound|END_ENTITY	Expression of plasma renin activity in terms of urinary sodium excretion and posture in normal subjects on free sodium intake .
6382488	0	sodium	56,62	renin	21,26	sodium	renin	MESH:D012964	5972	Chemical	Gene	excretion|compound|START_ENTITY terms|nmod|excretion activity|nmod|terms activity|compound|END_ENTITY	Expression of plasma renin activity in terms of urinary sodium excretion and posture in normal subjects on free sodium intake .
6749345	0	sodium	13,19	renin	28,33	sodium	renin	MESH:D012964	24715(Tax:10116)	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Exchangeable sodium , plasma renin activity and blood pressure changes during the development of 2 kidney 1 clip hypertension , and after subsequent contralateral nephrectomy .
6756166	0	sodium	38,44	renin	17,22	sodium	renin	MESH:D012964	24715(Tax:10116)	Chemical	Gene	deprivation|compound|START_ENTITY release|nmod|deprivation release|nsubj|Prostaglandin Prostaglandin|nmod|END_ENTITY	Prostaglandin in renin release during sodium deprivation .
6807681	0	sodium	97,103	renin	45,50	sodium	renin	MESH:D012964	5972	Chemical	Gene	diet|compound|START_ENTITY subjects|nmod|diet effect|nmod|subjects effect|nmod|END_ENTITY	The effect of oxprenolol and indomethacin on renin and aldosterone of normal subjects during low sodium diet .
6813454	0	sodium	78,84	renin	20,25	sodium	renin	MESH:D012964	100358545(Tax:9986)	Chemical	Gene	concentration|compound|START_ENTITY effect|nmod|concentration release|dep|effect release|compound|END_ENTITY	Active and inactive renin release from rabbit kidney cortex slices : effect of sodium concentration and of furosemide .
696414	0	sodium	13,19	renin	105,110	sodium	renin	MESH:D012964	5972	Chemical	Gene	intake|compound|START_ENTITY Influence|nmod|intake END_ENTITY|nsubj|Influence	Influence of sodium intake on hydrochlorothiazide-induced changes in blood pressure , serum electrolytes , renin and aldosterone in essential hypertension .
6988533	0	sodium	43,49	renin	27,32	sodium	renin	MESH:D012964	24715(Tax:10116)	Chemical	Gene	excretion|compound|START_ENTITY excretion|compound|END_ENTITY	Chronic effects of lead on renin and renal sodium excretion .
6991156	0	sodium	105,111	renin	45,50	sodium	renin	MESH:D012964	403838(Tax:9615)	Chemical	Gene	depletion|compound|START_ENTITY function|nmod|depletion function|nsubj|Effects Effects|nmod|indomethacin indomethacin|nmod|release release|compound|END_ENTITY	Effects of indomethacin and meclofenamate on renin release and renal hemodynamic function during chronic sodium depletion in conscious dogs .
7008667	0	sodium	34,40	renin	7,12	sodium	renin	MESH:D012964	5972	Chemical	Gene	excretion|compound|START_ENTITY END_ENTITY|dobj|excretion	Plasma renin activity and urinary sodium excretion as prognostic indicators in nonazotemic cirrhosis with ascites .
7018237	9	sodium	1579,1585	renin	1428,1433	sodium	renin	MESH:D012964	5972	Chemical	Gene	balance|compound|START_ENTITY alterations|nmod|balance sensitive|nmod|alterations indicates|ccomp|sensitive indicates|nsubj|difference difference|nmod|slopes slopes|nmod|lines lines|acl|relating relating|dobj|activity activity|compound|END_ENTITY	A significant difference between the slopes of the regression lines relating renin activity and sodium excretion for the two renin subgroups indicates that renin release in low renin patients is less sensitive to alterations in sodium balance .
7018257	0	sodium	11,17	renin	55,60	sodium	renin	MESH:D012964	24715(Tax:10116)	Chemical	Gene	intake|compound|START_ENTITY intake|nmod|release release|compound|END_ENTITY	Effects of sodium intake and Goldblatt hypertension on renin release in rat kidney slices .
7024992	0	sodium	106,112	renin	63,68	sodium	renin	MESH:D012964	403838(Tax:9615)	Chemical	Gene	depletion|compound|START_ENTITY inhibit|nmod|depletion inhibit|dobj|activity activity|compound|END_ENTITY	Failure of indomethacin to inhibit saralasin-stimulated plasma renin activity in conscious dogs with mild sodium depletion .
7026126	0	sodium	120,126	renin	83,88	sodium	renin	MESH:D012964	5972	Chemical	Gene	deprivation|compound|START_ENTITY END_ENTITY|nmod|deprivation	Water and electrolyte composition of urine and ileal fluid and its relationship to renin and aldosterone during dietary sodium deprivation in patients with ileostomies .
7033264	0	sodium	13,19	renin	75,80	sodium	renin	MESH:D012964	5972	Chemical	Gene	Influence|nmod|START_ENTITY homeostasis|nsubj|Influence homeostasis|nmod|modulation modulation|nmod|END_ENTITY	Influence of sodium homeostasis on dopaminergic modulation of aldosterone , renin , and prolactin secretion in man .
7037589	0	sodium	88,94	renin	28,33	sodium	renin	MESH:D012964	5972	Chemical	Gene	intake|compound|START_ENTITY aldosterone|nmod|intake aldosterone|nsubj|rhythms rhythms|nmod|END_ENTITY	Circadian rhythms of plasma renin , aldosterone and cortisol on habitual and low dietary sodium intake .
7047005	0	sodium	51,57	renin	91,96	sodium	renin	MESH:D012964	5972	Chemical	Gene	restriction|compound|START_ENTITY angiotensin_II|nmod|restriction angiotensin_II|nmod|subjects subjects|nmod|hypertension hypertension|amod|END_ENTITY	Aldosterone responsiveness to angiotensin_II after sodium restriction in subjects with low renin essential hypertension .
7049917	0	sodium	19,25	renin	52,57	sodium	renin	MESH:D012964	403838(Tax:9615)	Chemical	Gene	depletion|compound|START_ENTITY Effects|nmod|depletion Effects|nmod|END_ENTITY	Effects of chronic sodium depletion on canine brain renin and cathepsin_D activities .
71600	0	sodium	61,67	renin	7,12	sodium	renin	MESH:D012964	5972	Chemical	Gene	depletion|compound|START_ENTITY hypertension|nmod|depletion END_ENTITY|nmod|hypertension	Plasma renin and `` prorenin '' in essential hypertension during sodium depletion , beta-blockade , and reduced arterial pressure .
78048	0	sodium	48,54	renin	4,9	sodium	renin	MESH:D012964	5972	Chemical	Gene	intake|compound|START_ENTITY END_ENTITY|nmod|intake	Big renin in plasma of healthy subjects on high sodium intake .
7889179	8	sodium	1290,1296	renin	1086,1091	sodium	renin	MESH:D012964	5972	Chemical	Gene	normalized|nmod|START_ENTITY normalized|nsubj|activity activity|compound|END_ENTITY	Plasma renin activity and aldosterone plasma levels normalized 1 month later , with reappearance also of a plasma renin activity postural response and maintenance of normal potassium plasma levels even on a high sodium and normal potassium diet .
7943299	0	sodium	59,65	renin	17,22	sodium	renin	MESH:D012964	24715(Tax:10116)	Chemical	Gene	restriction|compound|START_ENTITY Enhanced|nmod|restriction Enhanced|dobj|END_ENTITY	Enhanced adrenal renin and aldosterone biosynthesis during sodium restriction in TGR -LRB- mREN2 -RRB- 27 .
7977783	0	sodium	13,19	renin	46,51	sodium	renin	MESH:D012964	24715(Tax:10116)	Chemical	Gene	diet|compound|START_ENTITY Influence|nmod|diet Influence|nmod|release release|compound|END_ENTITY	Influence of sodium diet on L-NAME effects on renin release and renal vasoconstriction .
8445983	0	sodium	104,110	renin	39,44	sodium	renin	MESH:D012964	24715(Tax:10116)	Chemical	Gene	diet|compound|START_ENTITY rats|nmod|diet Effect|nmod|rats Effect|nmod|activity activity|compound|END_ENTITY	Effect of caffeine treatment on plasma renin activity and angiotensin_I concentrations in rats on a low sodium diet .
846042	0	sodium	29,35	renin	20,25	sodium	renin	MESH:D012964	100358545(Tax:9986)	Chemical	Gene	load|compound|START_ENTITY END_ENTITY|nmod|load	Responses of plasma renin to sodium load in two types of experimental renal hypertension .
8717064	0	sodium	109,115	renin	40,45	sodium	renin	MESH:D012964	403838(Tax:9615)	Chemical	Gene	intake|compound|START_ENTITY effects|nmod|intake localization|dep|effects localization|nmod|END_ENTITY	Autoradiographic localization of active renin in the juxtaglomerular apparatus of the dog kidney : effects of sodium intake .
886216	0	sodium	62,68	renin	40,45	sodium	renin	MESH:D012964	5972	Chemical	Gene	restriction|compound|START_ENTITY activity|nmod|restriction activity|compound|END_ENTITY	Effects of potassium_chloride on plasma renin activity during sodium restriction in normal man .
8945984	0	sodium	8,14	renin	26,31	sodium	renin	MESH:D012964	24715(Tax:10116)	Chemical	Gene	effects|compound|START_ENTITY effects|nmod|expression expression|compound|END_ENTITY	Dietary sodium effects on renin and angiotensinogen gene expression in preweanling WKY and SHR .
907802	6	sodium	1006,1012	renin	960,965	sodium	renin	MESH:D012964	5972	Chemical	Gene	balance|compound|START_ENTITY dependent|nmod|balance dependent|nsubj|influence influence|nmod|decrease decrease|compound|END_ENTITY	The influence of the renin decrease on aldosterone is dependent on sodium balance and on the initial state of the renin angiotensin system .
9291199	0	sodium	67,73	renin	16,21	sodium	renin	MESH:D012964	5972	Chemical	Gene	Autonomy|dep|START_ENTITY Autonomy|nmod|system system|compound|END_ENTITY	Autonomy of the renin system in type_II_diabetes_mellitus : dietary sodium and renal hemodynamic responses to ACE inhibition .
984205	0	sodium	21,27	renin	31,36	sodium	renin	MESH:D012964	403838(Tax:9615)	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Influence of dietary sodium on renin activity and arterial pressure during anesthesia .
990387	0	sodium	16,22	renin	56,61	sodium	renin	MESH:D012964	5972	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|compound|END_ENTITY	Effect of acute sodium or potassium depletion on plasma renin activity in haemodialysed patients .
18729213	0	sodium	81,87	scn8aa	102,108	sodium	scn8aa	MESH:D012964	58152(Tax:7955)	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Multiple regulatory elements mediating neuronal-specific expression of zebrafish sodium channel gene , scn8aa .
9335501	0	sodium	64,70	serine_protease	14,29	sodium	serine protease	MESH:D012964	398015(Tax:8355)	Chemical	Gene	channel|compound|START_ENTITY activates|dobj|channel activates|nsubj|END_ENTITY	An epithelial serine_protease activates the amiloride-sensitive sodium channel .
1676328	0	sodium	65,71	somatostatin	26,38	sodium	somatostatin	MESH:D012964	443006(Tax:9940)	Chemical	Gene	intake|compound|START_ENTITY suppresses|dobj|intake suppresses|nsubj|administration administration|nmod|END_ENTITY	Central administration of somatostatin suppresses the stimulated sodium intake of sheep .
17200691	0	sodium	70,76	syntaxin1A	36,46	sodium	syntaxin1A	MESH:D012964	6804	Chemical	Gene	channel|compound|START_ENTITY END_ENTITY|nmod|channel	Distinct domain-dependent effect of syntaxin1A on amiloride-sensitive sodium channel -LRB- ENaC -RRB- currents in HT-29 colonic epithelial cells .
10521407	0	sodium	49,55	syntaxin_1A	67,78	sodium	syntaxin 1A	MESH:D012964	6804	Chemical	Gene	channel|compound|START_ENTITY Regulation|nmod|channel Regulation|nmod|END_ENTITY	Regulation of the amiloride-sensitive epithelial sodium channel by syntaxin_1A .
1706920	0	sodium	25,31	thrombomodulin	71,85	sodium	thrombomodulin	MESH:D012964	7056	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Enhancement by beraprost sodium , a stable analogue of prostacyclin , in thrombomodulin expression on membrane surface of cultured vascular endothelial cells via increase in cyclic_AMP level .
8829492	0	sodium	57,63	thrombomodulin	89,103	sodium	thrombomodulin	MESH:D012964	7056	Chemical	Gene	livedo_vasculitis|nmod|START_ENTITY treatment|nmod|livedo_vasculitis treatment|dep|mechanism mechanism|nmod|upregulation upregulation|compound|END_ENTITY	Successful treatment of livedo_vasculitis with beraprost sodium : a possible mechanism of thrombomodulin upregulation .
19150416	0	sodium	49,55	tumor_necrosis_factor-alpha	68,95	sodium	tumor necrosis factor-alpha	MESH:D012964	24835(Tax:10116)	Chemical	Gene	channels|compound|START_ENTITY channels|nmod|END_ENTITY	The regulation of amiloride-sensitive epithelial sodium channels by tumor_necrosis_factor-alpha in injured lungs and alveolar type II cells .
23362276	0	sodium	31,37	ubiquitin-like_protein_Nedd8	57,85	sodium	ubiquitin-like protein Nedd8	MESH:D012964	4738	Chemical	Gene	channel|compound|START_ENTITY channel|nmod|END_ENTITY	H2O2 regulates lung epithelial sodium channel -LRB- ENaC -RRB- via ubiquitin-like_protein_Nedd8 .
1081203	0	sodium	25,31	vasopressin	106,117	sodium	vasopressin	MESH:D012964	551	Chemical	Gene	content|compound|START_ENTITY furosemide|nmod|content skin|amod|furosemide Effects|nmod|skin Effects|dep|comparison comparison|nmod|END_ENTITY	Effects of furosemide on sodium content and transport pool in frog skin -LRB- Rana esculenta -RRB- : comparison with vasopressin and ouabain .
12219182	0	sodium	102,108	vasopressin	24,35	sodium	vasopressin	MESH:D012964	551	Chemical	Gene	intake|compound|START_ENTITY modulation|nmod|intake modulation|nmod|secretion secretion|compound|oxytocin oxytocin|compound|END_ENTITY	Nitrergic modulation of vasopressin , oxytocin and atrial natriuretic peptide secretion in response to sodium intake and hypertonic blood volume expansion .
14567502	0	sodium	35,41	vasopressin	58,69	sodium	vasopressin	MESH:D012964	551	Chemical	Gene	gene|compound|START_ENTITY regulation|nmod|gene regulation|nmod|END_ENTITY	Acute regulation of the epithelial sodium channel gene by vasopressin and hyperosmolality .
18614887	0	sodium	77,83	vasopressin	107,118	sodium	vasopressin	MESH:D012964	551	Chemical	Gene	paradox|compound|START_ENTITY paradox|nmod|secretion secretion|compound|END_ENTITY	Practical management of exercise-associated hyponatremic encephalopathy : the sodium paradox of non-osmotic vasopressin secretion .
21990032	0	sodium	103,109	vasopressin	47,58	sodium	vasopressin	MESH:D012964	551	Chemical	Gene	imbalance|compound|START_ENTITY diagnosis|nmod|imbalance use|nmod|diagnosis use|appos|peptide peptide|nmod|precursor precursor|compound|END_ENTITY	The use of copeptin , the stable peptide of the vasopressin precursor , in the differential diagnosis of sodium imbalance in patients with acute_diseases .
24965902	0	sodium	54,60	vasopressin	10,21	sodium	vasopressin	MESH:D012964	551	Chemical	Gene	handling|nmod|START_ENTITY antagonism|nmod|handling antagonism|nsubj|Effect Effect|nmod|END_ENTITY	Effect of vasopressin antagonism on renal handling of sodium and water and central and brachial blood pressure during inhibition of the nitric_oxide system in healthy subjects .
2551621	0	sodium	123,129	vasopressin	60,71	sodium	vasopressin	MESH:D012964	551	Chemical	Gene	acid|nmod|START_ENTITY acid|compound|END_ENTITY	-LSB- A comparative analysis of the effect of the synthetic SKD , vasopressin and asparaginic acid on the electrically sensitive sodium and potassium ion channels of neuronal somatic membrane -RSB- .
2673748	0	sodium	11,17	vasopressin	66,77	sodium	vasopressin	MESH:D012964	551	Chemical	Gene	depletion|compound|START_ENTITY Effects|nmod|depletion Effects|nmod|END_ENTITY	Effects of sodium depletion and orthostasis on plasma and urinary vasopressin in normal subjects .
2988106	0	sodium	69,75	vasopressin	9,20	sodium	vasopressin	MESH:D012964	551	Chemical	Gene	loading|compound|START_ENTITY END_ENTITY|nmod|loading	Arginine vasopressin and cyclic_adenosine_monophosphate during acute sodium loading in chronic glomerulonephritis .
3535395	0	sodium	14,20	vasopressin	64,75	sodium	vasopressin	MESH:D012964	551	Chemical	Gene	depletion|compound|START_ENTITY effect|nmod|depletion supplementation|nsubj|effect supplementation|nmod|END_ENTITY	The effect of sodium depletion and potassium supplementation on vasopressin , renin and catecholamines in hypertensive men .
3915319	0	sodium	8,14	vasopressin	32,43	sodium	vasopressin	MESH:D012964	551	Chemical	Gene	intake|compound|START_ENTITY increases|nsubj|intake increases|dobj|secretion secretion|compound|END_ENTITY	Dietary sodium intake increases vasopressin secretion in man .
4209873	0	sodium	87,93	vasopressin	11,22	sodium	vasopressin	MESH:D012964	551	Chemical	Gene	transport|nmod|START_ENTITY relationship|acl|transport Effects|dep|relationship Effects|nmod|END_ENTITY	Effects of vasopressin on toad bladder membrane proteins : relationship to transport of sodium and water .
4399668	0	sodium	51,57	vasopressin	28,39	sodium	vasopressin	MESH:D012964	551	Chemical	Gene	transport|compound|START_ENTITY stimulated|dobj|transport stimulated|nsubj|effect effect|nmod|END_ENTITY	Glycine-amide effect on the vasopressin stimulated sodium and water transport across toad bladder .
5575414	0	sodium	57,63	vasopressin	42,53	sodium	vasopressin	MESH:D012964	551	Chemical	Gene	transport|compound|START_ENTITY measurement|nmod|transport measurement|nmod|effect effect|nmod|END_ENTITY	Simultaneous measurement of the effect of vasopressin on sodium and water transport across toad bladder .
5654401	0	sodium	53,59	vasopressin	38,49	sodium	vasopressin	MESH:D012964	551	Chemical	Gene	transport|compound|START_ENTITY site|nmod|transport site|nmod|action action|nmod|END_ENTITY	The site of the stimulatory action of vasopressin on sodium transport in toad bladder .
583991	0	sodium	36,42	vasopressin	15,26	sodium	vasopressin	MESH:D012964	396995(Tax:9823)	Chemical	Gene	excretion|compound|START_ENTITY effects|nmod|excretion effects|nmod|END_ENTITY	The effects of vasopressin on renal sodium excretion in pigs given intravascular hypertonic salt loads .
6096988	0	sodium	114,120	vasopressin	38,49	sodium	vasopressin	MESH:D012964	551	Chemical	Gene	transport|compound|START_ENTITY effect|nmod|transport flow|nmod|effect flow|amod|END_ENTITY	Guanylylimidodiphosphate enhances the vasopressin - and vasotocin-induced osmotic water flow with no effect on the sodium transport of the frog bladder .
6385970	0	sodium	87,93	vasopressin	30,41	sodium	vasopressin	MESH:D012964	551	Chemical	Gene	influx|compound|START_ENTITY independent|nmod|influx independent|nsubj|mobilization mobilization|nmod|END_ENTITY	Rapid calcium mobilization by vasopressin and prostaglandin_F2_alpha is independent of sodium influx in quiescent 3T3 cells .
8287649	0	sodium	11,17	vasopressin	109,120	sodium	vasopressin	MESH:D012964	551	Chemical	Gene	excretion|compound|START_ENTITY Control|nmod|excretion -LSB-|nsubj|Control -LSB-|dobj|END_ENTITY	Control of sodium excretion in patients with cranial_diabetes_insipidus maintained on desamino - -LSB- 8-D-arginine -RSB- vasopressin .
12595915	0	sodium-hydrogen	58,73	NHE-1	95,100	sodium-hydrogen	NHE-1	null	6548	Chemical	Gene	isoform|amod|START_ENTITY isoform|appos|END_ENTITY	Zoniporide : a potent and selective inhibitor of the human sodium-hydrogen exchanger isoform 1 -LRB- NHE-1 -RRB- .
7961960	0	sodium-hydrogen	9,24	NHE-4	43,48	sodium-hydrogen	NHE-4	null	24785(Tax:10116)	Chemical	Gene	isoform|amod|START_ENTITY isoform|appos|END_ENTITY	A unique sodium-hydrogen exchange isoform -LRB- NHE-4 -RRB- of the inner medulla of the rat kidney is induced by hyperosmolarity .
23677982	0	sodium-hydrogen	12,27	NHE1	0,4	sodium-hydrogen	NHE1	null	20544(Tax:10090)	Chemical	Gene	exchanger|amod|START_ENTITY exchanger|nsubj|END_ENTITY	NHE1 is the sodium-hydrogen exchanger active in acute intracellular pH regulation in preimplantation mouse embryos .
9128283	0	sodium-phosphate	37,53	NPT2	74,78	sodium-phosphate	NPT2	MESH:C018279	6569	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	High resolution mapping of the renal sodium-phosphate cotransporter gene -LRB- NPT2 -RRB- confirms its localization to human chromosome 5q35 .
10710545	0	sodium-phosphate	55,71	Npt2	49,53	sodium-phosphate	Npt2	MESH:C018279	25548(Tax:10116)	Chemical	Gene	cotransporter|amod|START_ENTITY Role|appos|cotransporter Role|nmod|sites sites|nmod|regulation regulation|nmod|END_ENTITY	Role of AP2 consensus sites in regulation of rat Npt2 -LRB- sodium-phosphate cotransporter -RRB- promoter .
10830304	0	sodium-phosphate	97,113	Npt2	0,4	sodium-phosphate	Npt2	MESH:C018279	20505(Tax:10090)	Chemical	Gene	cotransport|amod|START_ENTITY hormone|nmod|cotransport action|nmod|hormone confers|nmod|action confers|nsubj|disruption disruption|amod|END_ENTITY	Npt2 gene disruption confers resistance to the inhibitory action of parathyroid hormone on renal sodium-phosphate cotransport .
10610722	0	sodium-phosphate	127,143	SLC34A2	166,173	sodium-phosphate	SLC34A2	MESH:C018279	10568	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Molecular cloning , functional characterization , tissue distribution , and chromosomal localization of a human , small intestinal sodium-phosphate -LRB- Na + - Pi -RRB- transporter -LRB- SLC34A2 -RRB- .
6991314	0	sodium_DL-lactate	11,28	insulin	32,39	sodium DL-lactate	insulin	null	483665(Tax:9615)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of sodium_DL-lactate on insulin secretion in anesthetized dogs .
16045009	0	sodium_aescinate	12,28	bcl-2	32,37	sodium aescinate	bcl-2	null	24224(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effects of sodium_aescinate on bcl-2 and caspase-3 expression and apoptosis after focal cerebral_ischemia reperfusion injury in rats -RSB- .
16357101	0	sodium_appetite	77,92	Corticotropin-releasing_hormone	0,31	sodium appetite	Corticotropin-releasing hormone	null	81648(Tax:10116)	Chemical	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Corticotropin-releasing_hormone in the lateral parabrachial nucleus inhibits sodium_appetite in rats .
8864301	0	sodium_appetite	46,61	Fos	14,17	sodium appetite	Fos	null	314322(Tax:10116)	Chemical	Gene	Expression|acl|START_ENTITY Expression|nmod|END_ENTITY	Expression of Fos in rat brain in relation to sodium_appetite : furosemide and cerebroventricular renin .
9174082	0	sodium_appetite	10,25	c-fos	37,42	sodium appetite	c-fos	null	314322(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Increased sodium_appetite stimulates c-fos expression in the organum vasculosum of the lamina terminalis .
16600567	0	sodium_arsenite	11,26	catalase	30,38	sodium arsenite	catalase	MESH:C017947	847	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|amod|END_ENTITY	Effects of sodium_arsenite on catalase activity , gene and protein expression in HaCaT cells .
15056798	0	sodium_arsenite	29,44	cyclooxygenase-2	52,68	sodium arsenite	cyclooxygenase-2	MESH:C017947	5743	Chemical	Gene	concentrations|nmod|START_ENTITY induce|nsubj|concentrations induce|dobj|expression expression|amod|END_ENTITY	Micromolar concentrations of sodium_arsenite induce cyclooxygenase-2 expression and stimulate p42/44 mitogen-activated protein kinase phosphorylation in normal human epidermal keratinocytes .
7600446	0	sodium_arsenite	96,111	cytochrome_P450_1A1	31,50	sodium arsenite	cytochrome P450 1A1	MESH:C017947	24296(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY END_ENTITY|nmod|administration	Selective increase of rat lung cytochrome_P450_1A1 dependent monooxygenase activity after acute sodium_arsenite administration .
9434882	0	sodium_arsenite	39,54	p53	13,16	sodium arsenite	p53	MESH:C017947	7157	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|expression expression|compound|END_ENTITY	Induction of p53 protein expression by sodium_arsenite .
9299480	0	sodium_arsenite	30,45	p70_S6_kinase	0,13	sodium arsenite	p70 S6 kinase	MESH:C017947	83840(Tax:10116)	Chemical	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	p70_S6_kinase is activated by sodium_arsenite in adult rat cardiomyocytes : roles for phosphatidylinositol 3-kinase and p38 MAP kinase .
27011749	0	sodium_ascorbate	74,90	superoxide_dismutase	26,46	sodium ascorbate	superoxide dismutase	MESH:D001205	6647	Chemical	Gene	START_ENTITY|nsubj|evaluation evaluation|nmod|END_ENTITY	Comparative evaluation of superoxide_dismutase , alpha-tocopherol , and 10 % sodium_ascorbate on reversal of shear bond strength of bleached enamel : An in vitro study .
11305939	0	sodium_bicarbonate	8,26	SLC4A9	84,90	sodium bicarbonate	SLC4A9	MESH:D017693	83697	Chemical	Gene	gene|amod|START_ENTITY gene|dep|END_ENTITY	A novel sodium_bicarbonate cotransporter-like gene in an ancient duplicated region : SLC4A9 at 5q31 .
2168155	0	sodium_bicarbonate	57,75	folylpolyglutamate_synthetase	24,53	sodium bicarbonate	folylpolyglutamate synthetase	MESH:D017693	2356	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of mammalian folylpolyglutamate_synthetase by sodium_bicarbonate .
9891019	0	sodium_bisulfite	56,72	S100A4	119,125	sodium bisulfite	S100A4	MESH:C009279	24615(Tax:10116)	Chemical	Gene	gene|nmod|START_ENTITY reactivity|nmod|gene associated|nsubjpass|reactivity associated|nmod|levels levels|nmod|mRNA mRNA|compound|END_ENTITY	Differential reactivity of the rat S100A4 -LRB- p9Ka -RRB- gene to sodium_bisulfite is associated with differential levels of the S100A4 -LRB- p9Ka -RRB- mRNA in rat mammary epithelial cells .
9891019	0	sodium_bisulfite	56,72	S100A4	35,41	sodium bisulfite	S100A4	MESH:C009279	24615(Tax:10116)	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Differential reactivity of the rat S100A4 -LRB- p9Ka -RRB- gene to sodium_bisulfite is associated with differential levels of the S100A4 -LRB- p9Ka -RRB- mRNA in rat mammary epithelial cells .
24683262	0	sodium_butyrate	44,59	53-kDa_protein	64,78	sodium butyrate	53-kDa protein	CHEBI:64103	7157	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effects of a histone deacetylase inhibitor , sodium_butyrate , on 53-kDa_protein expression and sensitivity to anticancer drugs of pancreatic_cancer cells .
10873561	0	sodium_butyrate	52,67	AA/C1	92,97	sodium butyrate	AA/C1	CHEBI:64103	9	Chemical	Gene	cells|amod|START_ENTITY cells|appos|END_ENTITY	Bile_acids reduce the apoptosis-inducing effects of sodium_butyrate on human colon_adenoma -LRB- AA/C1 -RRB- cells : implications for colon_carcinogenesis .
8503924	0	sodium_butyrate	34,49	C-fos	14,19	sodium butyrate	C-fos	CHEBI:64103	2353	Chemical	Gene	Caco-2|amod|START_ENTITY Regulation|nmod|Caco-2 Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of C-fos expression by sodium_butyrate in the human colon_carcinoma cell line Caco-2 .
21153085	0	sodium_butyrate	20,35	CCK	39,42	sodium butyrate	CCK	CHEBI:64103	885	Chemical	Gene	START_ENTITY|nmod|mRNA mRNA|compound|END_ENTITY	Opposite effects of sodium_butyrate on CCK mRNA and CCK peptide levels in RIN cells .
17940563	0	sodium_butyrate	73,88	CDAII	47,52	sodium butyrate	CDAII	CHEBI:64103	10483	Chemical	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	-LSB- In vitro study about the inhibitory effect of CDAII in combination with sodium_butyrate on breast_cancer cells -RSB- .
10949998	0	sodium_butyrate	90,105	E-cadherin	17,27	sodium butyrate	E-cadherin	CHEBI:64103	999	Chemical	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|END_ENTITY	Up-regulation of E-cadherin and I-catenin in human hepatocellular_carcinoma cell lines by sodium_butyrate and interferon-alpha .
16091294	0	sodium_butyrate	110,125	ERK	169,172	sodium butyrate	ERK	CHEBI:64103	5594	Chemical	Gene	microglia|nmod|START_ENTITY expression|nmod|microglia Repression|nmod|expression mediated|nsubjpass|Repression mediated|nmod|inhibition inhibition|nmod|END_ENTITY	Repression of interferon-gamma-induced inducible_nitric_oxide_synthase -LRB- iNOS -RRB- gene expression in microglia by sodium_butyrate is mediated through specific inhibition of ERK signaling pathways .
16800929	0	sodium_butyrate	84,99	ERK	1,4	sodium butyrate	ERK	CHEBI:64103	5594	Chemical	Gene	-RSB-|amod|START_ENTITY induced|nmod|-RSB- SKM-1|acl|induced change|dobj|SKM-1 change|nsubj|END_ENTITY	-LSB- ERK pathway change in the differentiation of human MDS cell lines SKM-1 induced by sodium_butyrate -RSB- .
17331472	7	sodium_butyrate	1058,1073	ERK	1035,1038	sodium butyrate	p38	CHEBI:64103	1432	Chemical	Gene	revealed|nmod|START_ENTITY revealed|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Analysis of MSCs induced in the presence of sodium_butyrate revealed an immediate increase in ERK phosphorylation by sodium_butyrate .
17331472	7	sodium_butyrate	985,1000	ERK	1035,1038	sodium butyrate	p38	CHEBI:64103	1432	Chemical	Gene	presence|nmod|START_ENTITY induced|nmod|presence MSCs|acl|induced Analysis|nmod|MSCs revealed|nsubj|Analysis revealed|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Analysis of MSCs induced in the presence of sodium_butyrate revealed an immediate increase in ERK phosphorylation by sodium_butyrate .
17540780	0	sodium_butyrate	89,104	NHE3	63,67	sodium butyrate	NHE3	CHEBI:64103	6550	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Involvement of Sp1 and Sp3 in differential regulation of human NHE3 promoter activity by sodium_butyrate and IFN-gamma/TNF-alpha .
24932233	0	sodium_butyrate	94,109	RbAp48	15,21	sodium butyrate	RbAp48	CHEBI:64103	19646(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of RbAp48 in erythroid differentiation of murine_erythroleukemia cells induced by sodium_butyrate .
2822731	0	sodium_butyrate	10,25	S-100	29,34	sodium butyrate	S-100	CHEBI:64103	6285	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|compound|END_ENTITY	Effect of sodium_butyrate on S-100 protein levels and the cAMP response .
19251437	0	sodium_butyrate	10,25	TL1A	52,56	sodium butyrate	TL1A	CHEBI:64103	9966	Chemical	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Effect of sodium_butyrate on lung vascular TNFSF15 -LRB- TL1A -RRB- expression : differential expression patterns in pulmonary artery and microvascular endothelial cells .
19251437	0	sodium_butyrate	10,25	TNFSF15	43,50	sodium butyrate	TNFSF15	CHEBI:64103	9966	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Effect of sodium_butyrate on lung vascular TNFSF15 -LRB- TL1A -RRB- expression : differential expression patterns in pulmonary artery and microvascular endothelial cells .
2408747	0	sodium_butyrate	10,25	alpha-fetoprotein	29,46	sodium butyrate	alpha-fetoprotein	CHEBI:64103	24177(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of sodium_butyrate on alpha-fetoprotein gene expression in rat hepatoma cells in vitro .
3066455	0	sodium_butyrate	11,26	beta-2-microglobulin	47,67	sodium butyrate	beta-2-microglobulin	CHEBI:64103	567	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|nmod|END_ENTITY	Effects of sodium_butyrate on the secretion of beta-2-microglobulin and calcitonin in a human ovarian_cancer cell line OC-3-VGH .
21560052	0	sodium_butyrate	34,49	brain-derived_neurotrophic_factor	70,103	sodium butyrate	brain-derived neurotrophic factor	CHEBI:64103	627	Chemical	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	The histone deacetylase inhibitor sodium_butyrate in combination with brain-derived_neurotrophic_factor reduces the viability of DAOY human medulloblastoma cells .
2114014	0	sodium_butyrate	64,79	c-fos	8,13	sodium butyrate	c-fos	CHEBI:64103	314322(Tax:10116)	Chemical	Gene	induction|nmod|START_ENTITY END_ENTITY|acl|induction	Unusual c-fos induction upon chromaffin PC12 differentiation by sodium_butyrate : loss of fos autoregulatory function .
3691477	0	sodium_butyrate	81,96	c-myc	67,72	sodium butyrate	c-myc	CHEBI:64103	4609	Chemical	Gene	abrogate|nmod|START_ENTITY abrogate|dobj|downregulation downregulation|nmod|gene gene|amod|END_ENTITY	Truncation does not abrogate transcriptional downregulation of the c-myc gene by sodium_butyrate in Burkitt 's _ lymphoma cells .
7558417	0	sodium_butyrate	42,57	c-myc	96,101	sodium butyrate	c-myc	CHEBI:64103	4609	Chemical	Gene	causes|nsubj|START_ENTITY causes|dobj|down-regulation down-regulation|nmod|END_ENTITY	Among 17 inducers of differentiation only sodium_butyrate causes a permanent down-regulation of c-myc in Burkitt 's _ lymphoma .
8325387	0	sodium_butyrate	34,49	c-myc	14,19	sodium butyrate	c-myc	CHEBI:64103	4609	Chemical	Gene	Caco-2|amod|START_ENTITY Regulation|nmod|Caco-2 Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of c-myc expression by sodium_butyrate in the colon_carcinoma cell line Caco-2 .
8281947	0	sodium_butyrate	95,110	cholesteryl-ester-transfer_protein	31,65	sodium butyrate	cholesteryl-ester-transfer protein	CHEBI:64103	1071	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|expression expression|nmod|END_ENTITY	The expression of human plasma cholesteryl-ester-transfer_protein in HepG2 cells is induced by sodium_butyrate .
215447	0	sodium_butyrate	10,25	cyclic_nucleotide_phosphodiesterase	81,116	sodium butyrate	cyclic nucleotide phosphodiesterase	CHEBI:64103	5140	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of sodium_butyrate in combination with prostaglandin_E1 and inhibitors of cyclic_nucleotide_phosphodiesterase on human amelanotic_melanoma cells in culture .
1517234	0	sodium_butyrate	10,25	estrogen_receptor	29,46	sodium butyrate	estrogen receptor	CHEBI:64103	2099	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of sodium_butyrate on estrogen_receptor and epidermal_growth_factor_receptor gene expression in human breast_cancer cell lines .
2009524	0	sodium_butyrate	46,61	germ_cell_alkaline_phosphatase	111,141	sodium butyrate	germ cell alkaline phosphatase	CHEBI:64103	251	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation and the effects of sodium_butyrate and glycosylation on catalytic activity of human germ_cell_alkaline_phosphatase .
9344607	0	sodium_butyrate	63,78	heat-shock_protein_70	14,35	sodium butyrate	heat-shock protein 70	CHEBI:64103	3308	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Modulation of heat-shock_protein_70 -LRB- HSP70 -RRB- gene expression by sodium_butyrate in U-937 promonocytic cells : relationships with differentiation and apoptosis .
2072929	0	sodium_butyrate	71,86	parathyroid_hormone-like_peptide	19,51	sodium butyrate	parathyroid hormone-like peptide	CHEBI:64103	24695(Tax:10116)	Chemical	Gene	induction|nmod|START_ENTITY induction|nmod|expression expression|amod|END_ENTITY	Rapid induction of parathyroid_hormone-like_peptide gene expression by sodium_butyrate in a rat islet cell line .
22441875	0	sodium_butyrate	55,70	pp3501	14,20	sodium butyrate	pp3501	CHEBI:64103	1043336(Tax:160488)	Chemical	Gene	effect|nmod|START_ENTITY mediates|dobj|effect mediates|nsubj|END_ENTITY	Novel protein pp3501 mediates the inhibitory effect of sodium_butyrate on SH-SY5Y cell proliferation .
2341406	0	sodium_butyrate	11,26	pregnancy-specific_beta_1-glycoprotein	53,91	sodium butyrate	pregnancy-specific beta 1-glycoprotein	CHEBI:64103	5673	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|synthesis synthesis|nmod|END_ENTITY	Effects of sodium_butyrate on the synthesis of human pregnancy-specific_beta_1-glycoprotein .
8220069	0	sodium_butyrate	10,25	retinoblastoma	47,61	sodium butyrate	retinoblastoma	CHEBI:64103	5925	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	Effect of sodium_butyrate on the expression of retinoblastoma -LRB- RB1 -RRB- and P53 gene and phosphorylation of retinoblastoma protein in human colon_tumor cell line HT29 .
7646441	0	sodium_butyrate	68,83	tissue-type_plasminogen_activator	15,48	sodium butyrate	tissue-type plasminogen activator	CHEBI:64103	5327	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Stimulation of tissue-type_plasminogen_activator gene expression by sodium_butyrate and trichostatin_A in human endothelial cells involves histone acetylation .
2895606	0	sodium_butyrate	14,29	tyrosine_aminotransferase	33,58	sodium butyrate	tyrosine aminotransferase	CHEBI:64103	24813(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|induction induction|amod|END_ENTITY	The effect of sodium_butyrate on tyrosine_aminotransferase induction in primary cultures of normal adult rat hepatocytes .
2328771	0	sodium_butyrate	45,60	vimentin	17,25	sodium butyrate	vimentin	CHEBI:64103	7431	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	The induction of vimentin gene expression by sodium_butyrate in human promonocytic_leukemia U937 cells .
8219018	0	sodium_chloride	64,79	c-Fos	0,5	sodium chloride	c-Fos	MESH:D012965	314322(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	c-Fos expression in the parabrachial nucleus after ingestion of sodium_chloride in the rat .
13195444	0	sodium_chloride	135,150	catalase	154,162	sodium chloride	catalase	MESH:D012965	100135492(Tax:10141)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	-LSB- Recent evaluations of the value of morphologic structures with special reference to catalase activity -LRB- Spirito 's oxyphore -RRB- ; effect of sodium_chloride on catalase activity of the blood in guinea_pigs -RSB- .
13195444	0	sodium_chloride	135,150	catalase	85,93	sodium chloride	catalase	MESH:D012965	100135492(Tax:10141)	Chemical	Gene	-RSB-|amod|START_ENTITY effect|nmod|-RSB- evaluations|dep|effect evaluations|acl|END_ENTITY	-LSB- Recent evaluations of the value of morphologic structures with special reference to catalase activity -LRB- Spirito 's oxyphore -RRB- ; effect of sodium_chloride on catalase activity of the blood in guinea_pigs -RSB- .
16198345	0	sodium_chloride	11,26	cyclooxygenase-2	40,56	sodium chloride	cyclooxygenase-2	MESH:D012965	5743	Chemical	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	Hypertonic sodium_chloride induction of cyclooxygenase-2 occurs independently of NF-kappaB and is inhibited by the glucocorticoid_receptor in A549 cells .
3884237	0	sodium_chloride	62,77	kallikrein	8,18	sodium chloride	kallikrein	MESH:D012965	9622	Chemical	Gene	infusion|amod|START_ENTITY END_ENTITY|nmod|infusion	Urinary kallikrein and systemic prostacyclin synthesis during sodium_chloride infusion in normal man .
964554	0	sodium_chloride	111,126	mucin	21,26	sodium chloride	mucin	MESH:D012965	65202(Tax:10116)	Chemical	Gene	effect|dep|START_ENTITY effect|nmod|END_ENTITY	Protective effect of mucin on experimental gastric_cancer induced by N-methyl-N ' - nitro-N-nitrosoguanidine plus sodium_chloride in rats .
19573005	0	sodium_chloride	13,28	p38	30,33	sodium chloride	p38	MESH:D012965	1432	Chemical	Gene	START_ENTITY|appos|protein protein|amod|END_ENTITY	Hyperosmolar sodium_chloride , p38 mitogen activated protein and cytokine-mediated inflammation .
13293	0	sodium_chloride	11,26	phenylethanolamine_N-methyltransferase	30,68	sodium chloride	phenylethanolamine N-methyltransferase	MESH:D012965	5409	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|amod|END_ENTITY	Effects of sodium_chloride on phenylethanolamine_N-methyltransferase activity .
31796	0	sodium_chloride	56,71	renin	47,52	sodium chloride	renin	MESH:D012965	24715(Tax:10116)	Chemical	Gene	Importance|nmod|START_ENTITY Importance|nmod|inhibition inhibition|nmod|END_ENTITY	Importance of chloride for acute inhibition of renin by sodium_chloride .
5125544	0	sodium_chloride	25,40	renin	53,58	sodium chloride	renin	MESH:D012965	24715(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	The influence of dietary sodium_chloride on in vitro renin release from rat kidney slices .
6882865	0	sodium_deoxycholate	49,68	apolipoprotein_B	27,43	sodium deoxycholate	apolipoprotein B	MESH:D003840	338	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of human serum apolipoprotein_B with sodium_deoxycholate .
9923695	0	sodium_dodecyl_sulfate	118,140	apolipoprotein_C-I	80,98	sodium dodecyl sulfate	apolipoprotein C-I	MESH:D012967	341	Chemical	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	Sequence-specific 1H NMR resonance assignments and secondary structure of human apolipoprotein_C-I in the presence of sodium_dodecyl_sulfate .
10903476	0	sodium_dodecyl_sulfate	98,120	apolipoprotein_C-II	59,78	sodium dodecyl sulfate	apolipoprotein C-II	MESH:D012967	344	Chemical	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	Structure of a biologically active fragment of human serum apolipoprotein_C-II in the presence of sodium_dodecyl_sulfate and dodecylphosphocholine .
6092079	0	sodium_dodecyl_sulfate	35,57	beta-endorphin	15,29	sodium dodecyl sulfate	beta-endorphin	MESH:D012967	5443	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of beta-endorphin with sodium_dodecyl_sulfate in aqueous solution .
7928089	0	sodium_dodecyl_sulfate	45,67	interleukin-2	28,41	sodium dodecyl sulfate	interleukin-2	MESH:D012967	3558	Chemical	Gene	Structure|nmod|START_ENTITY Structure|nmod|END_ENTITY	Structure and solubility of interleukin-2 in sodium_dodecyl_sulfate .
17889513	0	sodium_dodecyl_sulfate	77,99	lysozyme	65,73	sodium dodecyl sulfate	lysozyme	MESH:D012967	4069	Chemical	Gene	determination|nmod|START_ENTITY determination|nmod|END_ENTITY	A direct calorimetric determination of denaturation enthalpy for lysozyme in sodium_dodecyl_sulfate .
75728	0	sodium_dodecyl_sulphate	67,90	myelin_basic_protein	19,39	sodium dodecyl sulphate	myelin basic protein	CHEBI:8984	4155	Chemical	Gene	START_ENTITY|nsubj|Interaction Interaction|nmod|END_ENTITY	Interaction of the myelin_basic_protein with the anionic detergent sodium_dodecyl_sulphate .
18508387	0	sodium_fluoride	11,26	NaF	28,31	sodium fluoride	NaF	MESH:D012969	3576	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of sodium_fluoride -LRB- NaF -RRB- on the cilia and microtubular system of Tetrahymena .
24223512	0	sodium_fluoride	19,34	catalase	97,105	sodium fluoride	catalase	MESH:D012969	847	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nmod|effect	In vitro effect of sodium_fluoride on malondialdehyde concentration and on superoxide_dismutase , catalase , and glutathione peroxidase in human erythrocytes .
12802	0	sodium_fluoride	10,25	glucose-6-phosphate_dehydrogenase	29,62	sodium fluoride	glucose-6-phosphate dehydrogenase	MESH:D012969	24377(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	Effect of sodium_fluoride on glucose-6-phosphate_dehydrogenase activity in the rat uterus .
16892577	0	sodium_fluoride	11,26	sorbitol_dehydrogenase	46,68	sodium fluoride	sorbitol dehydrogenase	MESH:D012969	100355885(Tax:9986)	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	-LSB- Effect of sodium_fluoride on the activity of sorbitol_dehydrogenase in plasma and liver of rabbits with experimental atherosclerosis -RSB- .
20200113	0	sodium_glucose	47,61	SGLT1	79,84	sodium glucose	SGLT1	null	25552(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Restricted feeding phase shifts clock gene and sodium_glucose cotransporter 1 -LRB- SGLT1 -RRB- expression in rats .
22537769	0	sodium_glucose	57,71	SGLT1	87,92	sodium glucose	SGLT1	null	25552(Tax:10116)	Chemical	Gene	cotransporter|compound|START_ENTITY cotransporter|appos|END_ENTITY	KGA-2727 , a novel selective inhibitor of a high-affinity sodium_glucose cotransporter -LRB- SGLT1 -RRB- , exhibits antidiabetic efficacy in rodent models .
17050778	0	sodium_glucose	58,72	SGLT2	88,93	sodium glucose	SGLT2	null	6524	Chemical	Gene	cotransporter|compound|START_ENTITY cotransporter|appos|END_ENTITY	Sergliflozin , a novel selective inhibitor of low-affinity sodium_glucose cotransporter -LRB- SGLT2 -RRB- , validates the critical role of SGLT2 in renal glucose reabsorption and modulates plasma glucose level .
22548646	0	sodium_glucose	27,41	SGLT2	60,65	sodium glucose	SGLT2	null	6524	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Effect of canagliflozin , a sodium_glucose co-transporter 2 -LRB- SGLT2 -RRB- inhibitor , on bacteriuria and urinary_tract_infection in subjects with type 2 diabetes enrolled in a 12-week , phase 2 study .
23149871	0	sodium_glucose	96,110	SGLT2	128,133	sodium glucose	SGLT2	null	6524	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	Safety , tolerability , pharmacokinetics and pharmacodynamics of single doses of empagliflozin , a sodium_glucose cotransporter 2 -LRB- SGLT2 -RRB- inhibitor , in healthy Japanese subjects .
23733389	0	sodium_glucose	92,106	SGLT2	125,130	sodium glucose	SGLT2	null	6524	Chemical	Gene	inhibitor|compound|START_ENTITY inhibitor|compound|END_ENTITY	The effect of moderate hepatic_impairment on the pharmacokinetics of ipragliflozin , a novel sodium_glucose co-transporter 2 -LRB- SGLT2 -RRB- inhibitor .
23859488	0	sodium_glucose	66,80	SGLT2	98,103	sodium glucose	SGLT2	null	6524	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	Pharmacokinetics , pharmacodynamics and safety of empagliflozin , a sodium_glucose cotransporter 2 -LRB- SGLT2 -RRB- inhibitor , in subjects with renal_impairment .
23906374	0	sodium_glucose	40,54	SGLT2	72,77	sodium glucose	SGLT2	null	6524	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	Efficacy and safety of empagliflozin , a sodium_glucose cotransporter 2 -LRB- SGLT2 -RRB- inhibitor , as add-on to metformin in type 2 diabetes with mild hyperglycaemia .
24152604	0	sodium_glucose	59,73	SGLT2	91,96	sodium glucose	SGLT2	null	6524	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	Effect of food on the pharmacokinetics of empagliflozin , a sodium_glucose cotransporter 2 -LRB- SGLT2 -RRB- inhibitor , and assessment of dose proportionality in healthy volunteers .
25071027	0	sodium_glucose	48,62	SGLT2	80,85	sodium glucose	SGLT2	null	246787(Tax:10090)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Metformin supports the antidiabetic effect of a sodium_glucose cotransporter 2 -LRB- SGLT2 -RRB- inhibitor by suppressing endogenous glucose production in diabetic mice .
26474563	0	sodium_glucose	40,54	SGLT2	72,77	sodium glucose	SGLT2	null	6524	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Efficacy and safety of dapagliflozin , a sodium_glucose cotransporter 2 -LRB- SGLT2 -RRB- inhibitor , in diabetes_mellitus .
2664393	0	sodium_glycocholate	10,29	insulin	112,119	sodium glycocholate	insulin	CHEBI:36273	100009181(Tax:9986)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of sodium_glycocholate and polyoxyethylene-9-lauryl_ether on the hydrolysis of varying concentrations of insulin in the nasal homogenates of the albino rabbit .
15359571	0	sodium_hyaluronate	98,116	growth_hormone	77,91	sodium hyaluronate	growth hormone	MESH:D006820	2688	Chemical	Gene	using|dobj|START_ENTITY END_ENTITY|acl|using	Characterization and in vivo study of sustained-release formulation of human growth_hormone using sodium_hyaluronate .
10609311	0	sodium_hydroxybutyrate	11,33	carboxypeptidase_H	37,55	sodium hydroxybutyrate	carboxypeptidase H	null	25669(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	-LSB- Effect of sodium_hydroxybutyrate on carboxypeptidase_H activity and on angiotensin-converting enzyme in different regions of the rat brain -RSB- .
12043868	0	sodium_hypochlorite	50,69	Prep	25,29	sodium hypochlorite	Prep	MESH:D012973	5550	Chemical	Gene	Evaluation|nmod|START_ENTITY Evaluation|nmod|END_ENTITY	Evaluation of Glyde File Prep in combination with sodium_hypochlorite as a root canal irrigant .
17931047	0	sodium_iodide	110,123	carcinoembryonic_antigen	67,91	sodium iodide	carcinoembryonic antigen	MESH:D012974	1084	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Image-guided radioiodide therapy of medullary thyroid_cancer after carcinoembryonic_antigen promoter-targeted sodium_iodide symporter gene expression .
11001757	0	sodium_iodide	23,36	prolactin	10,19	sodium iodide	prolactin	MESH:D012974	19109(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Effect of prolactin on sodium_iodide symporter expression in mouse mammary gland explants .
1684465	0	sodium_lauryl_sulphate	24,46	CD1a	87,91	sodium lauryl sulphate	CD1a	CHEBI:8984	909	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|nmod|END_ENTITY	Differential effects of sodium_lauryl_sulphate and non-anoic_acid on the expression of CD1a and ICAM-1 in human epidermis .
25463229	0	sodium_metabisulfite	11,31	BKCa	53,57	sodium metabisulfite	BKCa	MESH:C005200	83731(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effects of sodium_metabisulfite on the expression of BKCa , KATP , and L-Ca -LRB- 2 + -RRB- channels in rat aortas in vivo and in vitro .
23439480	0	sodium_metabisulfite	17,37	Ghrelin	0,7	sodium metabisulfite	Ghrelin	MESH:C005200	59301(Tax:10116)	Chemical	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Ghrelin inhibits sodium_metabisulfite induced oxidative stress and apoptosis in rat gastric_mucosa .
25486021	0	sodium_metabisulfite	95,115	Ghrelin	154,161	sodium metabisulfite	Ghrelin	MESH:C005200	59301(Tax:10116)	Chemical	Gene	oxidase|nmod|START_ENTITY oxidase|nmod|END_ENTITY	Induction of xanthine oxidase activity , endoplasmic reticulum stress and caspase activation by sodium_metabisulfite in rat liver and their attenuation by Ghrelin .
21783565	1	sodium_metabisulfite	118,138	SMB	140,143	sodium metabisulfite	CA1	MESH:C005200	310218(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of sodium_metabisulfite -LRB- SMB -RRB- on voltage-gated sodium channel currents -LRB- I -LRB- Na -RRB- -RRB- was examined in freshly isolated rat hippocampal CA1 neurons using whole-cell patch-clamp technique under voltage-clamp conditions .
6714164	0	sodium_molybdate	11,27	androgen_receptor	35,52	sodium molybdate	androgen receptor	MESH:C024687	367	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of sodium_molybdate on the androgen_receptor from the R3327 prostatic_tumor .
1727055	0	sodium_n-butyrate	58,75	Transforming_growth_factor-beta_1	0,33	sodium n-butyrate	Transforming growth factor-beta 1	CHEBI:64103	7040	Chemical	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	Transforming_growth_factor-beta_1 acts cooperatively with sodium_n-butyrate to induce differentiation of normal human keratinocytes .
2578798	0	sodium_n-butyrate	11,28	alpha-fetoprotein	32,49	sodium n-butyrate	alpha-fetoprotein	CHEBI:64103	174	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of sodium_n-butyrate on alpha-fetoprotein and albumin secretion in the human hepatoma cell line PLC/PRF/5 .
1858930	0	sodium_nitrite	81,95	Myoglobin	0,9	sodium nitrite	Myoglobin	MESH:D012977	4151	Chemical	Gene	effect|nmod|START_ENTITY function|dep|effect function|amod|END_ENTITY	Myoglobin function and energy metabolism of isolated cardiac myocytes : effect of sodium_nitrite .
2619562	0	sodium_nitrite	42,56	myoglobin	21,30	sodium nitrite	myoglobin	MESH:D012977	4151	Chemical	Gene	Oxidation|nmod|START_ENTITY Oxidation|nmod|END_ENTITY	Oxidation of cardiac myoglobin in vivo by sodium_nitrite or hydroxylamine .
26687945	0	sodium_nitroprusside	67,87	Akt	107,110	sodium nitroprusside	Akt	MESH:D009599	24185(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nmod|END_ENTITY	Follistatin-like_1 protects cardiomyoblasts from injury induced by sodium_nitroprusside through modulating Akt and Smad1/5/9 signaling .
15465035	0	sodium_nitroprusside	25,45	HIF-1	49,54	sodium nitroprusside	HIF-1	MESH:D009599	3091	Chemical	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	The inhibitory effect of sodium_nitroprusside on HIF-1 activation is not dependent on nitric_oxide-soluble guanylyl cyclase pathway .
22544277	0	sodium_nitroprusside	23,43	Translocator_Protein	64,84	sodium nitroprusside	Translocator Protein	MESH:D009599	706	Chemical	Gene	requires|nsubj|START_ENTITY requires|dobj|END_ENTITY	The nitric_oxide donor sodium_nitroprusside requires the 18 kDa Translocator_Protein to induce cell death .
9137419	0	sodium_nitroprusside	20,40	c-myc	102,107	sodium nitroprusside	c-myc	MESH:D009599	4609	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|involvement involvement|nmod|expression expression|amod|END_ENTITY	Cytotoxic effect of sodium_nitroprusside on cancer cells : involvement of apoptosis and suppression of c-myc and c-myb proto-oncogene expression .
26738972	0	sodium_nitroprusside	11,31	catalase	53,61	sodium nitroprusside	catalase	MESH:D009599	12359(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of sodium_nitroprusside on mouse erythrocyte catalase activity and malondialdehyde status .
24610528	0	sodium_nitroprusside	81,101	iNOS	124,128	sodium nitroprusside	iNOS	MESH:D009599	24599(Tax:10116)	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Neuroprotective and anti-apoptotic propensity of Bacopa monniera extract against sodium_nitroprusside induced activation of iNOS , heat_shock proteins and apoptotic markers in PC12 cells .
8742019	0	sodium_nitroprusside	31,51	prolactin	84,93	sodium nitroprusside	prolactin	MESH:D009599	24683(Tax:10116)	Chemical	Gene	donors|amod|START_ENTITY Effects|nmod|donors Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of nitric_oxide donors sodium_nitroprusside and 3-morpholino-sydnonimine on prolactin secretion in conscious rats .
1372480	0	sodium_nitroprusside	14,34	thrombin	95,103	sodium nitroprusside	thrombin	MESH:D009599	2147	Chemical	Gene	Inhibition|nmod|START_ENTITY induced|nsubj|Inhibition induced|nmod|END_ENTITY	Inhibition by sodium_nitroprusside or PGE1 of tyrosine phosphorylation induced in platelets by thrombin or ADP .
1733268	0	sodium_oleate	43,56	cholecystokinin	11,26	sodium oleate	cholecystokinin	MESH:C013173	609547(Tax:9615)	Chemical	Gene	Release|nmod|START_ENTITY Release|nmod|END_ENTITY	Release of cholecystokinin and secretin by sodium_oleate in dogs : molecular form and bioactivity .
7250635	0	sodium_oleate	10,23	secretin	34,42	sodium oleate	secretin	MESH:C013173	483407(Tax:9615)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|concentration concentration|compound|END_ENTITY	Effect of sodium_oleate on plasma secretin concentration and pancreatic secretion in dog .
7535209	0	sodium_ortho_vanadate	99,120	interferon-gamma	48,64	sodium ortho vanadate	interferon-gamma	null	3458	Chemical	Gene	effect|nmod|START_ENTITY production|dep|effect production|amod|END_ENTITY	Tyrosine phosphorylation pathway is involved in interferon-gamma -LRB- IFN-gamma -RRB- production ; effect of sodium_ortho_vanadate .
6284912	0	sodium_orthovanadate	10,30	renin	40,45	sodium orthovanadate	renin	null	403838(Tax:9615)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of sodium_orthovanadate on renal renin secretion in vivo .
21447786	0	sodium_oxybate	10,24	growth_hormone	28,42	sodium oxybate	growth hormone	MESH:D012978	2688	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|amod|END_ENTITY	Effect of sodium_oxybate on growth_hormone secretion in narcolepsy patients and healthy controls .
15034091	0	sodium_phosphate	88,104	NaPi-IIa	120,128	sodium phosphate	NaPi-IIa	MESH:C018279	20505(Tax:10090)	Chemical	Gene	cotransporter|compound|START_ENTITY cotransporter|appos|END_ENTITY	Kidney-specific inactivation of the megalin gene impairs trafficking of renal inorganic sodium_phosphate cotransporter -LRB- NaPi-IIa -RRB- .
20458365	0	sodium_potassium_chloride	18,43	NCC	101,104	sodium potassium chloride	NCC	null	54300(Tax:10116)	Chemical	Gene	cotransporter|amod|START_ENTITY cotransporter|appos|END_ENTITY	Expression of the sodium_potassium_chloride cotransporter -LRB- NKCC1 -RRB- and sodium_chloride cotransporter -LRB- NCC -RRB- and their effects on rat lens transparency .
20458365	0	sodium_potassium_chloride	18,43	NKCC1	59,64	sodium potassium chloride	NKCC1	null	83629(Tax:10116)	Chemical	Gene	cotransporter|amod|START_ENTITY cotransporter|appos|END_ENTITY	Expression of the sodium_potassium_chloride cotransporter -LRB- NKCC1 -RRB- and sodium_chloride cotransporter -LRB- NCC -RRB- and their effects on rat lens transparency .
3006755	0	sodium_pyrophosphate	85,105	myosin	59,65	sodium pyrophosphate	myosin	MESH:C003319	79784	Chemical	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	Monomers , dimers , and minifilaments of vertebrate skeletal myosin in the presence of sodium_pyrophosphate .
8603385	0	sodium_saccharin	11,27	Her2/neu	64,72	sodium saccharin	Her2/neu	null	2064	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|nmod|END_ENTITY	Effects of sodium_saccharin and linoleic_acid on mRNA levels of Her2/neu and p53 in a human breast epithelial cell line .
8052854	0	sodium_salicylate	28,45	NF-kappa_B	14,24	sodium salicylate	NF-kappa B	MESH:D012980	4790	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of NF-kappa_B by sodium_salicylate and aspirin .
22533381	0	sodium_salicylate	67,84	biglycan	15,23	sodium salicylate	biglycan	MESH:D012980	12111(Tax:10090)	Chemical	Gene	target|nmod|START_ENTITY END_ENTITY|nmod|target	Adipose tissue biglycan as a potential anti-inflammatory target of sodium_salicylate in mice fed a high fat diet .
11955805	0	sodium_salicylate	65,82	insulin	17,24	sodium salicylate	insulin	MESH:D012980	483665(Tax:9615)	Chemical	Gene	containing|dobj|START_ENTITY capsules|acl|containing END_ENTITY|nmod|capsules	Oral delivery of insulin from enteric-coated capsules containing sodium_salicylate : effect on relative hypoglycemia of diabetic beagle_dogs .
3912157	0	sodium_salicylate	11,28	insulin	32,39	sodium salicylate	insulin	MESH:D012980	3630	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	-LSB- Effect of sodium_salicylate on insulin secretion and blood glucose behavior in metabolically healthy and type II diabetic patients -RSB- .
658622	0	sodium_salicylate	45,62	insulin	25,32	sodium salicylate	insulin	MESH:D012980	3630	Chemical	Gene	Restoration|nmod|START_ENTITY Restoration|nmod|response response|compound|END_ENTITY	Restoration of the acute insulin response by sodium_salicylate .
9876590	0	sodium_salicylate	102,119	insulin	28,35	sodium salicylate	insulin	MESH:D012980	100009181(Tax:9986)	Chemical	Gene	containing|dobj|START_ENTITY using|advcl|containing effect|acl|using effect|nmod|END_ENTITY	Hypoglycemic effect of oral insulin in diabetic rabbits using pH-dependent coated capsules containing sodium_salicylate without and with sodium_cholate .
8110432	0	sodium_salts	11,23	renin	34,39	sodium salts	renin	CHEBI:26714	5972	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of sodium_salts on plasma renin activity and norepinephrine response to orthostasis in salt-sensitive normotensive subjects .
17916949	0	sodium_selenite	24,39	Bcl-2	51,56	sodium selenite	Bcl-2	MESH:D018038	596	Chemical	Gene	therapy|compound|START_ENTITY therapy|nmod|expression expression|compound|END_ENTITY	The impact of high-dose sodium_selenite therapy on Bcl-2 expression in adult non-Hodgkin 's _ lymphoma patients : correlation with response and survival .
21549092	0	sodium_selenite	19,34	PC3	52,55	sodium selenite	PC3	MESH:D018038	57332	Chemical	Gene	effect|nmod|START_ENTITY effect|acl|END_ENTITY	Combined effect of sodium_selenite and docetaxel on PC3 metastatic prostate_cancer cell line .
22509550	0	sodium_selenite	12,27	beta-catenin	50,62	sodium selenite	beta-catenin	MESH:D018038	1499	Chemical	Gene	START_ENTITY|nmod|expressions expressions|nmod|END_ENTITY	-LSB- Effects of sodium_selenite on the expressions of beta-catenin and its target cyclin_D1 in colorectal_cancer cells HCT 116 and SW480 -RSB- .
19085995	0	sodium_sulfate	40,54	IkappaBa	75,83	sodium sulfate	IkappaBa	MESH:C012036	4792	Chemical	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	ROS , Hsp27 , and IKKbeta mediate dextran sodium_sulfate -LRB- DSS -RRB- activation of IkappaBa , NFkappaB , and IL-8 .
11161786	0	sodium_sulfate	16,30	SLC13A1	46,53	sodium sulfate	SLC13A1	MESH:C012036	6561	Chemical	Gene	cotransporter|compound|START_ENTITY cotransporter|appos|END_ENTITY	The human renal sodium_sulfate cotransporter -LRB- SLC13A1 ; hNaSi-1 -RRB- cDNA and gene : organization , chromosomal localization , and functional characterization .
24733425	0	sodium_sulfate	107,121	Signal-transducing_adaptor_protein-2	0,36	sodium sulfate	Signal-transducing adaptor protein-2	MESH:C012036	106766(Tax:10090)	Chemical	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Signal-transducing_adaptor_protein-2 regulates macrophage migration into inflammatory sites during dextran sodium_sulfate induced colitis .
23684440	0	sodium_sulfate	119,133	interleukin-23	77,91	sodium sulfate	interleukin-23	MESH:C012036	83430(Tax:10090)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|amod|END_ENTITY	White_button , _ portabella , and shiitake mushroom supplementation up-regulates interleukin-23 secretion in acute dextran sodium_sulfate colitis C57BL/6 mice and murine macrophage J. 744.1 cell line .
19821118	0	sodium_sulphate	88,103	tartrate_resistant_acid_phosphatase	37,72	sodium sulphate	tartrate resistant acid phosphatase	CHEBI:32149	25732(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Induction and cellular expression of tartrate_resistant_acid_phosphatase during dextran sodium_sulphate induced colitis in rats .
23173256	0	sodium_tanshinone_B	12,31	NMDAR1	61,67	sodium tanshinone B	NMDAR1	null	24408(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of sodium_tanshinone_B on the protein expression of NMDAR1 in rat hippocampal subfields following focal ischemia/reperfusion injury -RSB- .
18846332	0	sodium_tanshinone_IIA_sulfonate	110,141	c-fos	11,16	sodium tanshinone IIA sulfonate	c-fos	MESH:C024894	314322(Tax:10116)	Chemical	Gene	Changes|nmod|START_ENTITY Changes|nmod|END_ENTITY	Changes of c-fos and c-jun mRNA expression in angiotensin_II-induced cardiomyocyte hypertrophy and effects of sodium_tanshinone_IIA_sulfonate .
19534587	0	sodium_tanshinone_II_A_sulfonate	10,42	CYP1A2	62,68	sodium tanshinone II A sulfonate	CYP1A2	MESH:C024894	1544	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|nmod|END_ENTITY	Effect of sodium_tanshinone_II_A_sulfonate on the activity of CYP1A2 in healthy volunteers .
25650312	0	sodium_taurocholate	69,88	NTCP	117,121	sodium taurocholate	NTCP	MESH:D013656	6554	Chemical	Gene	-RSB-|amod|START_ENTITY -RSB-|compound|END_ENTITY	Design and synthesis of a novel candidate compound NTI-007 targeting sodium_taurocholate cotransporting polypeptide -LSB- NTCP -RSB- - APOA1-HBx-Beclin1-mediated autophagic pathway in HBV therapy .
6424998	0	sodium_thiomalate	30,47	Antithrombin	0,12	sodium thiomalate	Antithrombin	null	462	Chemical	Gene	START_ENTITY|nsubj|activity activity|compound|END_ENTITY	Antithrombin activity of gold sodium_thiomalate .
10227815	0	sodium_thiomalate	58,75	B_cell_activation	32,49	sodium thiomalate	B cell activation	null	29760	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Synergistic inhibition of human B_cell_activation by gold sodium_thiomalate and auranofin .
9543700	0	sodium_thiomalate	43,60	bcl-2	70,75	sodium thiomalate	bcl-2	null	596	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effects of 2-chlorodeoxyadenosine and gold sodium_thiomalate on human bcl-2 gene expression .
7526148	0	sodium_thiomalate	5,22	intercellular_adhesion_molecule-1_and_vascular_cell_adhesion_molecule-1	38,109	sodium thiomalate	intercellular adhesion molecule-1 and vascular cell adhesion molecule-1	null	3383;7412	Chemical	Gene	START_ENTITY|dobj|expression expression|amod|END_ENTITY	Gold sodium_thiomalate down-regulates intercellular_adhesion_molecule-1_and_vascular_cell_adhesion_molecule-1 expression on vascular endothelial cells .
2107989	0	sodium_thiomalate	19,36	interleukin-1	81,94	sodium thiomalate	interleukin-1	null	3552	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|production production|amod|END_ENTITY	The effect of gold sodium_thiomalate and auranofin on lipopolysaccharide-induced interleukin-1 production by blood monocytes in vitro : variation in healthy subjects and patients with arthritis .
2977403	0	sodium_thiomalate	60,77	thrombin	81,89	sodium thiomalate	thrombin	null	2147	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Biological action of colorless and yellow solutions of gold sodium_thiomalate on thrombin activity and the mixed lymphocyte reaction .
9278181	0	sodium_thiomalate	24,41	tumor_necrosis_factor	62,83	sodium thiomalate	tumor necrosis factor	null	7124	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	In vitro effect of gold sodium_thiomalate and methotrexate on tumor_necrosis_factor production in normal healthy individuals and patients with rheumatoid_arthritis .
12473262	0	sodium_thiomalate	5,22	tumor_necrosis_factor-alpha	69,96	sodium thiomalate	tumor necrosis factor-alpha	null	7124	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Gold sodium_thiomalate -LRB- GSTM -RRB- inhibits lipopolysaccharide stimulated tumor_necrosis_factor-alpha through ceramide pathway .
1619320	0	sodium_thiosulfate	90,108	angiotensin_II	129,143	sodium thiosulfate	angiotensin II	MESH:C017717	183	Chemical	Gene	START_ENTITY|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- The clinical and pharmacokinetic evaluation of two-route chemotherapy with cisplatin and sodium_thiosulfate in combination with angiotensin_II -RSB- .
6223661	0	sodium_trichloroacetate	17,40	ATPase	98,104	sodium trichloroacetate	ATPase	MESH:D014238	1769	Chemical	Gene	influence|nmod|START_ENTITY influence|nmod|END_ENTITY	The influence of sodium_trichloroacetate on the tryptophan fluorescence of sarcoplasmic reticulum ATPase .
18483800	0	sodium_tungstate	27,43	GLUT4	86,91	sodium tungstate	GLUT4	MESH:C025399	6517	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|nmod|END_ENTITY	The glucose-lowering agent sodium_tungstate increases the levels and translocation of GLUT4 in L6 myotubes through a mechanism associated with ERK1/2 and MEF2D .
6327800	0	sodium_valproate	32,48	ACTH	8,12	sodium valproate	ACTH	MESH:D014635	5443	Chemical	Gene	effect|nmod|START_ENTITY lowering|dobj|effect Lack|acl|lowering Lack|nmod|END_ENTITY	Lack of ACTH lowering effect of sodium_valproate in patients with ACTH_hypersecretion .
8582096	0	sodium_valproate	10,26	ACTH	50,54	sodium valproate	ACTH	MESH:D014635	5443	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of sodium_valproate on naloxone-stimulated ACTH and cortisol release in humans .
12504922	0	sodium_valproate	73,89	Akt	14,17	sodium valproate	Akt	MESH:D014635	207	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of Akt and glycogen_synthase_kinase-3_beta phosphorylation by sodium_valproate and lithium .
24128869	0	sodium_valproate	25,41	BDNF	126,130	sodium valproate	BDNF	MESH:D014635	24225(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|compound|END_ENTITY	Antidepressive effect of sodium_valproate involving suppression of corticotropin-releasing_factor expression and elevation of BDNF expression in rats exposed to chronic unpredicted stress .
78084	0	sodium_valproate	26,42	Fibrinogen	0,10	sodium valproate	Fibrinogen	MESH:D014635	2244	Chemical	Gene	depletion|nmod|START_ENTITY depletion|compound|END_ENTITY	Fibrinogen depletion with sodium_valproate .
24890032	0	sodium_valproate	3,19	HDAC	24,28	sodium valproate	HDAC	MESH:D014635	9734	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Is sodium_valproate , an HDAC inhibitor , associated with reduced risk of stroke and myocardial_infarction ?
3148149	0	sodium_valproate	22,38	Prolactin	0,9	sodium valproate	Prolactin	MESH:D014635	5617	Chemical	Gene	START_ENTITY|nsubj|response response|compound|END_ENTITY	Prolactin response to sodium_valproate in schizophrenics with and without tardive_dyskinesia .
16842952	0	sodium_valproate	96,112	Protein_C	0,9	sodium valproate	Protein C	MESH:D014635	5624	Chemical	Gene	using|dobj|START_ENTITY END_ENTITY|acl|using	Protein_C , protein S and other pro- and anticoagulant activities among epileptic children using sodium_valproate .
22588906	0	sodium_valproate	22,38	SPC-A1	63,69	sodium valproate	SPC-A1	MESH:D014635	27032	Chemical	Gene	START_ENTITY|nmod|proliferation proliferation|compound|END_ENTITY	-LSB- Inhibitory effect of sodium_valproate on human lung_carcinoma SPC-A1 cell proliferation and the mechanism -RSB- .
2548660	0	sodium_valproate	14,30	angiotensin_II	96,110	sodium valproate	angiotensin II	MESH:D014635	183	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition by sodium_valproate of the arginine_vasopressin and adrenocorticotropin responses to angiotensin_II in normal men .
3027601	0	sodium_valproate	11,27	beta-endorphin	44,58	sodium valproate	beta-endorphin	MESH:D014635	5443	Chemical	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	Effects of sodium_valproate and diazepam on beta-endorphin , beta-lipotropin and cortisol secretion induced by hypoglycemic stress in humans .
2996808	0	sodium_valproate	111,127	corticotrophin-releasing_factor	69,100	sodium valproate	corticotrophin-releasing factor	MESH:D014635	1392	Chemical	Gene	administration|compound|START_ENTITY administration|amod|END_ENTITY	Unaltered stimulation of pituitary adrenocorticotrophin secretion by corticotrophin-releasing_factor following sodium_valproate administration in a patient with Nelson 's _ syndrome .
24128869	0	sodium_valproate	25,41	corticotropin-releasing_factor	67,97	sodium valproate	corticotropin-releasing factor	MESH:D014635	81648(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|suppression suppression|nmod|expression expression|amod|END_ENTITY	Antidepressive effect of sodium_valproate involving suppression of corticotropin-releasing_factor expression and elevation of BDNF expression in rats exposed to chronic unpredicted stress .
3082095	0	sodium_valproate	28,44	growth_hormone	55,69	sodium valproate	growth hormone	MESH:D014635	2688	Chemical	Gene	treatment|nmod|START_ENTITY effect|nmod|treatment END_ENTITY|nsubj|effect	No effect of treatment with sodium_valproate on plasma growth_hormone in bromocriptine unresponsive acromegaly .
1814797	0	sodium_valproate	41,57	oxytocin	65,73	sodium valproate	oxytocin	MESH:D014635	5020	Chemical	Gene	START_ENTITY|nmod|responses responses|compound|END_ENTITY	Different effects of the GABAergic agent sodium_valproate on the oxytocin responses to angiotensin_II and insulin-induced hypoglycemia in normal men .
1525801	0	sodium_valproate	10,26	prolactin	47,56	sodium valproate	prolactin	MESH:D014635	5617	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|nmod|END_ENTITY	Effect of sodium_valproate on the secretion of prolactin , cortisol and growth_hormone in migraine patients .
3003777	0	sodium_valproate	31,47	prolactin	72,81	sodium valproate	prolactin	MESH:D014635	5617	Chemical	Gene	START_ENTITY|xcomp|reduce reduce|dobj|secretion secretion|compound|END_ENTITY	Failure of the GABAergic drug , sodium_valproate , to reduce basal plasma prolactin secretion in chronic schizophrenia .
6426828	0	sodium_valproate	31,47	prolactin	56,65	sodium valproate	prolactin	MESH:D014635	5617	Chemical	Gene	drug|appos|START_ENTITY drug|nmod|release release|compound|END_ENTITY	Effects of the GABAergic drug , sodium_valproate , on the prolactin release evoked by pharmacological stimuli in normal women .
2561274	0	sodium_valproate	10,26	proopiomelanocortin	47,66	sodium valproate	proopiomelanocortin	MESH:D014635	24664(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|nmod|END_ENTITY	Effect of sodium_valproate on the secretion of proopiomelanocortin derived peptides from cultured rat anterior pituitary cells .
7964759	0	sodium_valproate	8,24	protein_kinase_C_alpha	47,69	sodium valproate	protein kinase C alpha	MESH:D014635	24680(Tax:10116)	Chemical	Gene	decreases|nsubj|START_ENTITY decreases|dobj|END_ENTITY	Chronic sodium_valproate selectively decreases protein_kinase_C_alpha and epsilon in vitro .
2903170	0	sodium_valproate	15,31	somatostatin	42,54	sodium valproate	somatostatin	MESH:D014635	6750	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of sodium_valproate on plasma somatostatin and insulin in humans .
22041898	0	sodium_vitamin_C	23,39	SVCT-2	55,61	sodium vitamin C	SVCT-2	null	9962	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Nitric_oxide modulates sodium_vitamin_C transporter 2 -LRB- SVCT-2 -RRB- protein expression via protein kinase G -LRB- PKG -RRB- and nuclear factor-kB -LRB- NF-kB -RRB- .
7189775	0	sodiumselenite	133,147	glutathione_peroxidase	162,184	sodiumselenite	glutathione peroxidase	MESH:D018038	100306295(Tax:3847)	Chemical	Gene	Availability|nmod|START_ENTITY Availability|acl|restoring restoring|dobj|activity activity|amod|END_ENTITY	Availability of selenium in fish meal in comparison with soybean meal , corn gluten meal and selenomethionine relative to selenium in sodiumselenite for restoring glutathione_peroxidase activity in selenium-depleted chicks .
9479623	0	sofalcone	10,19	hepatocyte_growth_factor	41,65	sofalcone	hepatocyte growth factor	MESH:C035032	3082	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	Effect of sofalcone on the expression of hepatocyte_growth_factor -LRB- HGF -RRB- and a brief review of HGF in the stomach .
11447767	0	sofalcone	21,30	tumor_necrosis_factor-alpha	34,61	sofalcone	tumor necrosis factor-alpha	MESH:C035032	7124	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|production production|amod|END_ENTITY	Inhibitory effect of sofalcone on tumor_necrosis_factor-alpha and interleukin-1_beta production in human monocytes stimulated by Helicobacter_pylori water extract .
9872518	0	sofalcone	99,108	vascular_endothelial_growth_factor	21,55	sofalcone	vascular endothelial growth factor	MESH:C035032	7422	Chemical	Gene	release|amod|START_ENTITY effect|nmod|release role|dep|effect role|nmod|END_ENTITY	The possible role of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in gastric ulcer_healing : effect of sofalcone on VEGF release in vitro .
17885815	0	solamargine	39,50	HER2/neu	18,26	solamargine	HER2/neu	MESH:C026609	2064	Chemical	Gene	receptor|nmod|START_ENTITY receptor|amod|END_ENTITY	Downregulation of HER2/neu receptor by solamargine enhances anticancer drug-mediated cytotoxicity in breast_cancer cells with high-expressing HER2/neu .
22088467	0	solamargine	81,92	P-glycoprotein	52,66	solamargine	P-glycoprotein	MESH:C026609	5243	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Induction of actin disruption and downregulation of P-glycoprotein expression by solamargine in multidrug-resistant K562/A02 cells .
11543478	0	solid_amine	35,46	CO2	47,50	solid amine	CO2	null	717	Chemical	Gene	-RSB-|amod|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- The study on CO2 concentration in solid_amine CO2 control system -RSB- .
21599020	0	solomonsterol_A	56,71	pregnane-X-receptor	89,108	solomonsterol A	pregnane-X-receptor	MESH:C561233	8856	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Total synthesis and pharmacological characterization of solomonsterol_A , a potent marine pregnane-X-receptor agonist endowed with anti-inflammatory activity .
22733410	0	solomonsterol_A	34,49	pregnane-X-receptor	96,115	solomonsterol A	pregnane-X-receptor	MESH:C561233	8856	Chemical	Gene	chain|nmod|START_ENTITY Modification|nmod|chain Modification|dep|discovery discovery|nmod|cholestan_disulfate cholestan_disulfate|nmod|agonist agonist|amod|END_ENTITY	Modification in the side chain of solomonsterol_A : discovery of cholestan_disulfate as a potent pregnane-X-receptor agonist .
2276342	0	soman	94,99	Acetylcholinesterase	0,20	soman	Acetylcholinesterase	MESH:D012999	100422792	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|inhibition inhibition|amod|END_ENTITY	Acetylcholinesterase inhibition by -LRB- + -RRB- physostigmine and efficacy against lethality induced by soman .
23817175	0	soman	122,127	Acetylcholinesterase	0,20	soman	Acetylcholinesterase	MESH:D012999	83817(Tax:10116)	Chemical	Gene	exposure|compound|START_ENTITY plays|nmod|exposure plays|nsubj|inhibition inhibition|amod|END_ENTITY	Acetylcholinesterase inhibition in the basolateral amygdala plays a key role in the induction of status_epilepticus after soman exposure .
22984913	0	soman	19,24	acetylcholinesterase	35,55	soman	acetylcholinesterase	MESH:D012999	43	Chemical	Gene	mechanism|nmod|START_ENTITY inhibited|nsubj|mechanism inhibited|xcomp|END_ENTITY	Aging mechanism of soman inhibited acetylcholinesterase .
2730340	0	soman	13,18	acetylcholinesterase	103,123	soman	acetylcholinesterase	MESH:D012999	11423(Tax:10090)	Chemical	Gene	poisoning|compound|START_ENTITY Survivors|nmod|poisoning Survivors|dep|recovery recovery|nmod|LD50 LD50|acl|control control|nmod|presence presence|nmod|inhibition inhibition|compound|END_ENTITY	Survivors of soman poisoning : recovery of the soman LD50 to control value in the presence of extensive acetylcholinesterase inhibition .
2730340	0	soman	46,51	acetylcholinesterase	103,123	soman	acetylcholinesterase	MESH:D012999	11423(Tax:10090)	Chemical	Gene	LD50|amod|START_ENTITY LD50|acl|control control|nmod|presence presence|nmod|inhibition inhibition|compound|END_ENTITY	Survivors of soman poisoning : recovery of the soman LD50 to control value in the presence of extensive acetylcholinesterase inhibition .
2842166	0	soman	122,127	acetylcholinesterase	37,57	soman	acetylcholinesterase	MESH:D012999	83817(Tax:10116)	Chemical	Gene	intoxication|compound|START_ENTITY Contribution|nmod|intoxication Contribution|nmod|synthesis synthesis|nmod|END_ENTITY	Contribution of de novo synthesis of acetylcholinesterase to spontaneous recovery of neuromuscular transmission following soman intoxication .
3055428	0	soman	83,88	acetylcholinesterase	15,35	soman	acetylcholinesterase	MESH:D012999	83817(Tax:10116)	Chemical	Gene	pinacolyl_methylphosphonofluoridate|dobj|START_ENTITY pinacolyl_methylphosphonofluoridate|nsubj|Effects Effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Effects of the acetylcholinesterase inhibitor pinacolyl_methylphosphonofluoridate -LRB- soman -RRB- on selected endocrine , glucose , and catecholamine levels in fasted and fed rats .
3603567	0	soman	61,66	acetylcholinesterase	131,151	soman	acetylcholinesterase	MESH:D012999	83817(Tax:10116)	Chemical	Gene	actions|nmod|START_ENTITY Differences|nmod|actions organophosphorus|nsubj|Differences organophosphorus|dobj|inhibitors inhibitors|nmod|END_ENTITY	Differences in central and peripheral neural actions between soman and diisopropyl_fluorophosphate , organophosphorus inhibitors of acetylcholinesterase .
4033355	0	soman	85,90	acetylcholinesterase	32,52	soman	acetylcholinesterase	MESH:D012999	83817(Tax:10116)	Chemical	Gene	lethality|compound|START_ENTITY Relationship|nmod|lethality Relationship|nmod|inhibition inhibition|amod|END_ENTITY	Relationship between reversible acetylcholinesterase inhibition and efficacy against soman lethality .
4079656	0	soman	10,15	acetylcholinesterase	58,78	soman	acetylcholinesterase	MESH:D012999	83817(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of soman on schedule-controlled behavior and brain acetylcholinesterase in rats .
4084346	0	soman	54,59	acetylcholinesterase	70,90	soman	acetylcholinesterase	MESH:D012999	43	Chemical	Gene	ageing|nmod|START_ENTITY atropine|nmod|ageing Influence|nmod|atropine inhibited|nsubj|Influence inhibited|dobj|END_ENTITY	Influence of atropine upon ageing and reactivation of soman inhibited acetylcholinesterase from human erythrocytes .
7092921	0	soman	90,95	acetylcholinesterase	45,65	soman	acetylcholinesterase	MESH:D012999	83817(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY END_ENTITY|nmod|inhibition	HI-6 : reactivation of central and peripheral acetylcholinesterase following inhibition by soman , sarin and tabun in vivo in the rat .
8343983	0	soman	33,38	acetylcholinesterase	98,118	soman	acetylcholinesterase	MESH:D012999	83817(Tax:10116)	Chemical	Gene	simulator|compound|START_ENTITY pretreatment|nmod|simulator effects|nmod|pretreatment effects|dep|interactions interactions|nmod|END_ENTITY	The effects of pretreatment with soman simulator in the skeletal muscle : direct interactions with acetylcholinesterase .
8359835	0	soman	73,78	acetylcholinesterase	34,54	soman	acetylcholinesterase	MESH:D012999	83817(Tax:10116)	Chemical	Gene	toxicity|compound|START_ENTITY END_ENTITY|nmod|toxicity	Comparative efficacy of exogenous acetylcholinesterase administration on soman and dichlorvos toxicity in rats .
8382066	0	soman	17,22	acetylcholinesterase	76,96	soman	acetylcholinesterase	MESH:D012999	83817(Tax:10116)	Chemical	Gene	influence|nmod|START_ENTITY simulator|nsubj|influence simulator|nmod|HI-6 HI-6|nmod|END_ENTITY	The influence of soman simulator on reactivation by HI-6 of soman-inhibited acetylcholinesterase in preparations of rat and human skeletal muscle .
8494502	0	soman	49,54	acetylcholinesterase	88,108	soman	acetylcholinesterase	MESH:D012999	43	Chemical	Gene	system|nmod|START_ENTITY system|acl|using using|dobj|protection protection|nmod|END_ENTITY	A homogeneous immunological detection system for soman using the in vitro protection of acetylcholinesterase by a monoclonal antibody .
8750900	0	soman	103,108	acetylcholinesterase	69,89	soman	acetylcholinesterase	MESH:D012999	43	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubj|reactivation reactivation|nmod|END_ENTITY	Methantheline improves the reactivation by HI 6 of human erythrocyte acetylcholinesterase inhibited by soman in vitro .
9389209	0	soman	169,174	acetylcholinesterase	185,205	soman	acetylcholinesterase	MESH:D012999	100009390(Tax:9986)	Chemical	Gene	erythrocytes|nmod|START_ENTITY transfusion|nmod|erythrocytes rabbit|nmod|transfusion brain|nmod|rabbit activity|nmod|brain Changes|nmod|activity inhibited|nsubj|Changes inhibited|xcomp|END_ENTITY	Changes of cholinesterase activity in the erythrocytes , plasma , diaphragm , liver and various parts of the brain in the rabbit following transfusion of erythrocytes with soman inhibited acetylcholinesterase .
2866234	0	soman	17,22	calmodulin	87,97	soman	calmodulin	MESH:D012999	24242(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|system system|compound|END_ENTITY	Acute effects of soman , sarin , and tabun on microsomal and cytosolic components of the calmodulin system in rat striatum .
3687318	0	somatomedin	16,27	Growth_hormone	0,14	somatomedin	Growth hormone	MESH:D013002	2688	Chemical	Gene	levels|amod|START_ENTITY END_ENTITY|appos|levels	Growth_hormone , somatomedin levels and growth regulation in Turner 's _ syndrome .
6752166	0	somatomedin	42,53	growth_hormone	14,28	somatomedin	growth hormone	MESH:D013002	2688	Chemical	Gene	levels|compound|START_ENTITY effect|nmod|levels effect|nmod|treatment treatment|amod|END_ENTITY	The effect of growth_hormone treatment on somatomedin levels in growth_hormone-deficient children .
229685	0	somatomedin_A	16,29	growth_hormone	115,129	somatomedin A	growth hormone	MESH:D007335	2688	Chemical	Gene	levels|nmod|START_ENTITY levels|nmod|END_ENTITY	Serum levels of somatomedin_A and growth during long-term treatment of patients with pituitary_dwarfism with human growth_hormone .
1126310	0	somatosatin	33,44	gastrin	14,21	somatosatin	gastrin	null	25320(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of gastrin release by somatosatin in vitro .
6108208	0	somatostatin	11,23	ACTH	56,60	somatostatin	ACTH	MESH:D013004	5443	Chemical	Gene	START_ENTITY|nmod|level level|compound|END_ENTITY	Effects of somatostatin and bromocryptine on the plasma ACTH level in bilaterally adrenalectomized patients with Cushing 's _ disease .
21539874	0	somatostatin	32,44	ANP	15,18	somatostatin	ANP	MESH:D013004	24602(Tax:10116)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Suppression Suppression|nmod|END_ENTITY	Suppression of ANP secretion by somatostatin through somatostatin_receptor type 2 .
12573799	0	somatostatin	26,38	Adrenomedullin	0,14	somatostatin	Adrenomedullin	MESH:D013004	25026(Tax:10116)	Chemical	Gene	stimulates|dobj|START_ENTITY stimulates|nsubj|END_ENTITY	Adrenomedullin stimulates somatostatin and thus inhibits histamine and acid secretion in the fundus of the stomach .
12105853	0	somatostatin	53,65	Amylin	0,6	somatostatin	Amylin	MESH:D013004	15874(Tax:10090)	Chemical	Gene	stimulates|dobj|START_ENTITY stimulates|nsubj|END_ENTITY	Amylin , released from the gastric fundus , stimulates somatostatin and thus inhibits histamine and acid secretion in mice .
10898757	0	somatostatin	54,66	CCK	11,14	somatostatin	CCK	MESH:D013004	885	Chemical	Gene	release|compound|START_ENTITY roles|nmod|release _|dep|roles _|compound|END_ENTITY	Pancreatic CCK -LRB- B -RRB- _ receptors : their potential roles in somatostatin release and delta-cell proliferation .
7797020	6	somatostatin	940,952	CCK	979,982	somatostatin	CCK	MESH:D013004	25298(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY increase|nmod|levels blocked|nsubjpass|increase blocked|nmod|L364 L364|compound|END_ENTITY	The increase in somatostatin levels was blocked by the CCK antagonist L364 ,718 .
9457654	0	somatostatin	32,44	CCK	17,20	somatostatin	CCK	MESH:D013004	101116683	Chemical	Gene	secretion|compound|START_ENTITY regulates|dobj|secretion regulates|nsubj|Cholecystokinin Cholecystokinin|appos|END_ENTITY	Cholecystokinin -LRB- CCK -RRB- regulates somatostatin secretion through both the CCK-A and CCK-B/gastrin receptors in sheep .
2460071	0	somatostatin	122,134	CGRP	58,62	somatostatin	CGRP	MESH:D013004	796	Chemical	Gene	VIP|appos|START_ENTITY VIP|appos|END_ENTITY	Immunohistochemical studies of the neurochemical markers , CGRP , enkephalin , galanin , gamma-MSH , NPY , PHI , proctolin , PTH , somatostatin , SP , VIP , tyrosine hydroxylase and neurofilament in nerves and cells of the human attached_gingiva .
2477154	0	somatostatin	23,35	CGRP	16,20	somatostatin	CGRP	MESH:D013004	396256(Tax:9031)	Chemical	Gene	Distribution|dep|START_ENTITY Distribution|nmod|END_ENTITY	Distribution of CGRP - , somatostatin - , galanin - , VIP - , and substance P-immunoreactive nerve fibers in the chicken carotid body .
1364195	0	somatostatin	58,70	Ca2	36,39	somatostatin	Ca2	MESH:D013004	12349(Tax:10090)	Chemical	Gene	agonists|amod|START_ENTITY +|nmod|agonists +|nsubj|regulation regulation|nmod|END_ENTITY	Synergistic regulation of cytosolic Ca2 + concentration by somatostatin and alpha 1-adrenergic agonists in mouse astrocytes .
2870914	0	somatostatin	43,55	Calcitonin_gene-related_peptide	0,31	somatostatin	Calcitonin gene-related peptide	MESH:D013004	24241(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Calcitonin_gene-related_peptide stimulates somatostatin release from isolated perfused rat stomach .
7657098	0	somatostatin	70,82	Calcitonin_gene-related_peptide	0,31	somatostatin	Calcitonin gene-related peptide	MESH:D013004	24241(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Calcitonin_gene-related_peptide modulates_acid-mediated regulation of somatostatin and gastrin release from rat antrum .
7902270	0	somatostatin	73,85	Calcitonin_gene-related_peptide-I	0,33	somatostatin	Calcitonin gene-related peptide-I	MESH:D013004	24241(Tax:10116)	Chemical	Gene	secretion|nmod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Calcitonin_gene-related_peptide-I preferentially stimulates secretion of somatostatin from intestinal cultures .
15074389	0	somatostatin	70,82	Cholecystokinin	0,15	somatostatin	Cholecystokinin	MESH:D013004	397468(Tax:9823)	Chemical	Gene	secretion|compound|START_ENTITY secretion|nmod|secretion inhibits|dobj|secretion inhibits|nsubj|END_ENTITY	Cholecystokinin inhibits gastrin secretion independently of paracrine somatostatin secretion in the pig .
9457654	0	somatostatin	32,44	Cholecystokinin	0,15	somatostatin	Cholecystokinin	MESH:D013004	101116683	Chemical	Gene	secretion|compound|START_ENTITY regulates|dobj|secretion regulates|nsubj|END_ENTITY	Cholecystokinin -LRB- CCK -RRB- regulates somatostatin secretion through both the CCK-A and CCK-B/gastrin receptors in sheep .
6152434	0	somatostatin	63,75	E2_and_D2	39,48	somatostatin	E2 and D2	MESH:D013004	299201(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY END_ENTITY|nmod|release	Different effects of prostaglandin_E1 , E2_and_D2 on pancreatic somatostatin release .
8661191	0	somatostatin	62,74	Epidermal_growth_factor	0,23	somatostatin	Epidermal growth factor	MESH:D013004	25313(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY improves|nmod|administration improves|nsubj|END_ENTITY	Epidermal_growth_factor improves intestinal adaptation during somatostatin administration in vivo .
1347739	0	somatostatin	137,149	GH	124,126	somatostatin	GH	MESH:D013004	81668(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Time-dependent reduction and potentiation of growth_hormone -LRB- GH -RRB- responsiveness to GH-releasing_factor induced by exogenous GH : role for somatostatin .
2563734	0	somatostatin	151,163	GH	93,95	somatostatin	GH	MESH:D013004	2688	Chemical	Gene	secretion|nmod|START_ENTITY END_ENTITY|acl|secretion	Half-time of endogenous growth_hormone -LRB- GH -RRB- disappearance in normal man after stimulation of GH secretion by GH-releasing hormone and suppression with somatostatin .
16835832	0	somatostatin	47,59	GHRH	61,65	somatostatin	GHRH	MESH:D013004	29446(Tax:10116)	Chemical	Gene	Recruiting|nmod|START_ENTITY secretagogue|advcl|Recruiting secretagogue|nsubj|END_ENTITY	Recruiting of somatotroph cells after combined somatostatin , GHRH and growth_hormone -LRB- GH -RRB- secretagogue stimulation in a study of pituitary GH reserve in prepuberal female rats .
2883595	0	somatostatin	21,33	GHRH	138,142	somatostatin	GHRH	MESH:D013004	29446(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY infusions|nsubj|Effect infusions|xcomp|END_ENTITY	Effect of continuous somatostatin and growth_hormone-releasing_hormone -LRB- GHRH -RRB- infusions on the subsequent growth_hormone -LRB- GH -RRB- response to GHRH .
2883595	0	somatostatin	21,33	GHRH	72,76	somatostatin	GHRH	MESH:D013004	29446(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of continuous somatostatin and growth_hormone-releasing_hormone -LRB- GHRH -RRB- infusions on the subsequent growth_hormone -LRB- GH -RRB- response to GHRH .
2238756	6	somatostatin	1042,1054	GIP	1024,1027	somatostatin	GIP	MESH:D013004	25040(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY alter|dobj|release alter|nsubj|END_ENTITY	GIP did not alter somatostatin release at a perfusate glucose concentration of 70 mg/dl while at 150 mg/dl only the highest dose of GIP -LRB- 10 -LRB- -8 -RRB- M -RRB- stimulated somatostatin release significantly .
2238756	6	somatostatin	1182,1194	GIP	1024,1027	somatostatin	GIP	MESH:D013004	25040(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY stimulated|dobj|release GIP|acl|stimulated dose|nmod|GIP mg/dl|dobj|dose alter|advcl|mg/dl alter|nsubj|END_ENTITY	GIP did not alter somatostatin release at a perfusate glucose concentration of 70 mg/dl while at 150 mg/dl only the highest dose of GIP -LRB- 10 -LRB- -8 -RRB- M -RRB- stimulated somatostatin release significantly .
6112787	0	somatostatin	14,26	GIP	62,65	somatostatin	GIP	MESH:D013004	2695	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of somatostatin on fasting and postprandial plasma GIP , serum insulin , and blood glucose in man .
6127273	3	somatostatin	606,618	GIP	715,718	somatostatin	GIP	MESH:D013004	2695	Chemical	Gene	dose|compound|START_ENTITY decreased|nsubj|dose decreased|dobj|levels levels|nmod|END_ENTITY	The same somatostatin dose infused 30 min after the ingestion of glucose decreased significantly the raised levels of GIP and insulin and further increased blood glucose levels .
1675472	0	somatostatin	81,93	GRF	103,106	somatostatin	GRF	MESH:D013004	29446(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|compound|END_ENTITY	In vitro release of growth_hormone-releasing_factor -LRB- GRF -RRB- from the hypothalamus : somatostatin inhibits GRF release .
1675472	0	somatostatin	81,93	GRF	53,56	somatostatin	GRF	MESH:D013004	29446(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|release release|nmod|growth_hormone-releasing_factor growth_hormone-releasing_factor|appos|END_ENTITY	In vitro release of growth_hormone-releasing_factor -LRB- GRF -RRB- from the hypothalamus : somatostatin inhibits GRF release .
1684146	0	somatostatin	39,51	GRF	113,116	somatostatin	GRF	MESH:D013004	2691	Chemical	Gene	immunization|nmod|START_ENTITY Effects|nmod|immunization and/or|nsubj|Effects and/or|dobj|injections injections|nmod|growth_hormone-releasing_factor growth_hormone-releasing_factor|appos|END_ENTITY	Effects of active immunization against somatostatin -LRB- SRIF -RRB- and/or injections of growth_hormone-releasing_factor -LRB- GRF -RRB- during gestation on hormonal and metabolic profiles in sows .
1979154	0	somatostatin	31,43	GRF	49,52	somatostatin	GRF	MESH:D013004	29446(Tax:10116)	Chemical	Gene	injection|nmod|START_ENTITY injection|appos|END_ENTITY	Intrahypothalamic injection of somatostatin , not GRF , stimulates prolactin secretion .
2859017	0	somatostatin	118,130	GRF	0,3	somatostatin	GRF	MESH:D013004	2691	Chemical	Gene	interaction|nmod|START_ENTITY activator|dep|interaction activator|nsubj|END_ENTITY	GRF is a highly potent activator of adenylate cyclase in the normal human , bovine and rat pituitary : interaction with somatostatin .
18795252	0	somatostatin	107,119	Glucagon-like_peptide-1	0,23	somatostatin	Glucagon-like peptide-1	MESH:D013004	24952(Tax:10116)	Chemical	Gene	secretion|nmod|START_ENTITY inhibits|dobj|secretion inhibits|nsubj|END_ENTITY	Glucagon-like_peptide-1 , but not glucose-dependent_insulinotropic_peptide , inhibits glucagon secretion via somatostatin -LRB- receptor subtype 2 -RRB- in the perfused rat pancreas .
21680696	0	somatostatin	31,43	Glucagon-like_peptide-1	0,23	somatostatin	Glucagon-like peptide-1	MESH:D013004	2641	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	Glucagon-like_peptide-1 versus somatostatin receptor targeting reveals 2 distinct forms of malignant_insulinomas .
11720883	0	somatostatin	43,55	Growth_hormone	0,14	somatostatin	Growth hormone	MESH:D013004	403795(Tax:9615)	Chemical	Gene	withdrawal|compound|START_ENTITY rise|dobj|withdrawal rise|nsubj|END_ENTITY	Growth_hormone -LRB- GH -RRB- rebound rise following somatostatin infusion withdrawal : studies in dogs with the use of GH-releasing hormone and a GH-releasing peptide .
23184260	0	somatostatin	101,113	Growth_hormone	0,14	somatostatin	Growth hormone	MESH:D013004	2688	Chemical	Gene	receptor|compound|START_ENTITY correlate|nmod|receptor response|amod|correlate subtype|dobj|response subtype|nsubj|pattern pattern|amod|END_ENTITY	Growth_hormone granulation pattern and somatostatin receptor subtype 2A correlate with postoperative somatostatin receptor ligand response in acromegaly : a large single center experience .
23794116	0	somatostatin	131,143	Growth_hormone	0,14	somatostatin	Growth hormone	MESH:D013004	2688	Chemical	Gene	receptor|compound|START_ENTITY add|nmod|receptor values|advcl|add values|nsubj|END_ENTITY	Growth_hormone values after an oral glucose load do not add clinically useful information in patients with acromegaly on long-term somatostatin receptor ligand treatment .
7714111	0	somatostatin	134,146	Growth_hormone	0,14	somatostatin	Growth hormone	MESH:D013004	2688	Chemical	Gene	analog|compound|START_ENTITY dose|nmod|analog comparison|nmod|dose hypersecretion|dep|comparison hypersecretion|amod|END_ENTITY	Growth_hormone hypersecretion in a girl with McCune-Albright_syndrome : comparison with controls and response to a dose of long-acting somatostatin analog .
7745020	0	somatostatin	77,89	Growth_hormone	0,14	somatostatin	Growth hormone	MESH:D013004	2688	Chemical	Gene	inhibits|nmod|START_ENTITY hormone|acl|inhibits END_ENTITY|dep|hormone	Growth_hormone -LRB- GH -RRB- - releasing hormone tonically inhibits in vitro endogenous somatostatin in human GH-secreting tumors .
810343	0	somatostatin	46,58	Growth_hormone	0,14	somatostatin	Growth hormone	MESH:D013004	81668(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY release|dep|effects release|amod|END_ENTITY	Growth_hormone release in the rat : effects of somatostatin and thyrotropin-releasing_factor .
8106120	0	somatostatin	25,37	Growth_hormone	0,14	somatostatin	Growth hormone	MESH:D013004	81668(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY increases|dobj|release increases|nsubj|END_ENTITY	Growth_hormone increases somatostatin release and messenger ribonucleic_acid levels in the rat hypothalamus .
9231841	0	somatostatin	138,150	Growth_hormone	0,14	somatostatin	Growth hormone	MESH:D013004	2688	Chemical	Gene	analogue|compound|START_ENTITY octreotide|appos|analogue effects|nmod|octreotide responses|dep|effects responses|compound|END_ENTITY	Growth_hormone and insulin-like_growth_factor_I responses to moderate submaximal acute physical exercise in man : effects of octreotide , a somatostatin analogue , administration .
7904758	0	somatostatin	42,54	Growth_hormone-releasing_factor	0,31	somatostatin	Growth hormone-releasing factor	MESH:D013004	29446(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|increases increases|compound|END_ENTITY	Growth_hormone-releasing_factor increases somatostatin release and mRNA levels in the rat periventricular nucleus via nitric_oxide by activation of guanylate cyclase .
17505159	0	somatostatin	44,56	IGF-I	14,19	somatostatin	IGF-I	MESH:D013004	3479	Chemical	Gene	levels|nmod|START_ENTITY levels|amod|END_ENTITY	Evaluation of IGF-I levels during long-term somatostatin analogs treatment in patients with gastroenteropancreatic_endocrine_tumors .
7903898	0	somatostatin	117,129	Insulin-like_growth_factor_I	0,28	somatostatin	Insulin-like growth factor I	MESH:D013004	24482(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY increased|dobj|release growth_hormone_releasing_factor|acl|increased modulates|nmod|growth_hormone_releasing_factor modulates|nsubj|END_ENTITY	Insulin-like_growth_factor_I modulates hypothalamic somatostatin through a growth_hormone_releasing_factor increased somatostatin release and messenger ribonucleic_acid levels .
7903898	0	somatostatin	52,64	Insulin-like_growth_factor_I	0,28	somatostatin	Insulin-like growth factor I	MESH:D013004	24482(Tax:10116)	Chemical	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	Insulin-like_growth_factor_I modulates hypothalamic somatostatin through a growth_hormone_releasing_factor increased somatostatin release and messenger ribonucleic_acid levels .
9389553	0	somatostatin	38,50	Leptin	0,6	somatostatin	Leptin	MESH:D013004	25608(Tax:10116)	Chemical	Gene	secretion|compound|START_ENTITY inhibits|nmod|secretion inhibits|nsubj|END_ENTITY	Leptin inhibits in vitro hypothalamic somatostatin secretion and somatostatin mRNA levels .
10207097	0	somatostatin	14,26	MIBP1	75,80	somatostatin	MIBP1	MESH:D013004	15273(Tax:10090)	Chemical	Gene	Activation|nmod|START_ENTITY receptor|nsubj|Activation receptor|nmod|END_ENTITY	Activation of somatostatin receptor II expression by transcription factors MIBP1 and SEF-2 in the murine brain .
15618885	0	somatostatin	20,32	NPY	0,3	somatostatin	NPY	MESH:D013004	4852	Chemical	Gene	receptor|compound|START_ENTITY subtype|nsubj|receptor express|ccomp|subtype express|nsubj|neurons neurons|compound|END_ENTITY	NPY neurons express somatostatin receptor subtype 1 in the arcuate_nucleus .
21640760	0	somatostatin	21,33	NPY	41,44	somatostatin	NPY	MESH:D013004	4852	Chemical	Gene	START_ENTITY|nmod|response response|compound|END_ENTITY	Inhibitory effect of somatostatin on the NPY response to insulin-induced hypoglycemia and the role of endogenous opioids .
2460071	0	somatostatin	122,134	NPY	96,99	somatostatin	NPY	MESH:D013004	4852	Chemical	Gene	VIP|appos|START_ENTITY VIP|appos|END_ENTITY	Immunohistochemical studies of the neurochemical markers , CGRP , enkephalin , galanin , gamma-MSH , NPY , PHI , proctolin , PTH , somatostatin , SP , VIP , tyrosine hydroxylase and neurofilament in nerves and cells of the human attached_gingiva .
6122561	0	somatostatin	75,87	Neurotensin	21,32	somatostatin	Neurotensin	MESH:D013004	299757(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY polypeptide|nmod|release polypeptide|nsubj|Effects Effects|nmod|END_ENTITY	Effects of glucagon , Neurotensin , and vasoactive intestinal polypeptide on somatostatin release from perifused rat hypothalamus .
15358539	0	somatostatin	13,25	P-glycoprotein	51,65	somatostatin	P-glycoprotein	MESH:D013004	5243	Chemical	Gene	Transport|nmod|START_ENTITY Transport|nmod|END_ENTITY	Transport of somatostatin and substance_P by human P-glycoprotein .
2460071	0	somatostatin	122,134	PTH	117,120	somatostatin	PTH	MESH:D013004	5741	Chemical	Gene	VIP|appos|START_ENTITY VIP|appos|END_ENTITY	Immunohistochemical studies of the neurochemical markers , CGRP , enkephalin , galanin , gamma-MSH , NPY , PHI , proctolin , PTH , somatostatin , SP , VIP , tyrosine hydroxylase and neurofilament in nerves and cells of the human attached_gingiva .
11096356	0	somatostatin	70,82	RC-160	90,96	somatostatin	RC-160	MESH:D013004	3240093(Tax:185588)	Chemical	Gene	vitro|nmod|START_ENTITY END_ENTITY|amod|vitro	Inhibition of human epithelial_ovarian_cancer cell growth in vitro by somatostatin analog RC-160 .
12972574	0	somatostatin	39,51	SHP-1	84,89	somatostatin	SHP-1	MESH:D013004	5777	Chemical	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Critical role of Src and SHP-2 in sst2 somatostatin receptor-mediated activation of SHP-1 and inhibition of cell proliferation .
9927304	0	somatostatin	38,50	SHP-1	134,139	somatostatin	SHP-1	MESH:D013004	5777	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|role role|nmod|END_ENTITY	Inhibitory and stimulatory effects of somatostatin on two human pancreatic_cancer cell lines : a primary role for tyrosine phosphatase SHP-1 .
18025811	0	somatostatin	34,46	SSTR	165,169	somatostatin	SSTR	MESH:D013004	171044(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY model|nmod|receptor allows|nsubj|model allows|dobj|studies studies|acl|using using|dobj|imaging imaging|nmod|expression expression|amod|END_ENTITY	An orthotopic model of pancreatic somatostatin receptor -LRB- SSTR -RRB- - positive tumors allows bimodal imaging studies using 3T MRI and animal PET-based molecular imaging of SSTR expression .
18025811	0	somatostatin	34,46	SSTR	57,61	somatostatin	SSTR	MESH:D013004	171044(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	An orthotopic model of pancreatic somatostatin receptor -LRB- SSTR -RRB- - positive tumors allows bimodal imaging studies using 3T MRI and animal PET-based molecular imaging of SSTR expression .
12657967	0	somatostatin	11,23	SSTR-5	55,61	somatostatin	SSTR-5	MESH:D013004	20609(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|nmod|END_ENTITY	Pancreatic somatostatin inhibits insulin secretion via SSTR-5 in the isolated perfused mouse pancreas model .
7968260	0	somatostatin	19,31	SSTR1	51,56	somatostatin	SSTR1	MESH:D013004	6751	Chemical	Gene	subtypes|compound|START_ENTITY subtypes|appos|END_ENTITY	Gene expression of somatostatin receptor subtypes , SSTR1 and SSTR2 , in human lung_cancer cell lines .
10071756	0	somatostatin	35,47	SSTR2	65,70	somatostatin	SSTR2	MESH:D013004	54305(Tax:10116)	Chemical	Gene	type-2|advmod|START_ENTITY receptor|amod|type-2 receptor|appos|END_ENTITY	A microplate binding assay for the somatostatin type-2 receptor -LRB- SSTR2 -RRB- .
18298437	0	somatostatin	38,50	SSTR2	142,147	somatostatin	SSTR2	MESH:D013004	20606(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY levels|nmod|receptors levels|nmod|ileum ileum|nmod|mice mice|compound|END_ENTITY	Distribution and expression levels of somatostatin and somatostatin receptors in the ileum of normal and acutely Schistosoma_mansoni-infected SSTR2 knockout/lacZ knockin mice .
22932785	0	somatostatin	35,47	SSTR2	0,5	somatostatin	SSTR2	MESH:D013004	6752	Chemical	Gene	receptor|compound|START_ENTITY receptor|nsubj|END_ENTITY	SSTR2 is the functionally dominant somatostatin receptor in human pancreatic b - and a-cells .
7488212	0	somatostatin	106,118	SSTR2	148,153	somatostatin	SSTR2	MESH:D013004	54305(Tax:10116)	Chemical	Gene	the|nmod|START_ENTITY necessary|nmod|the END_ENTITY|amod|necessary	Identification of a critical aspartate residue in transmembrane domain three necessary for the binding of somatostatin to the somatostatin receptor SSTR2 .
7488212	0	somatostatin	126,138	SSTR2	148,153	somatostatin	SSTR2	MESH:D013004	54305(Tax:10116)	Chemical	Gene	somatostatin|nmod|START_ENTITY the|nmod|somatostatin necessary|nmod|the END_ENTITY|amod|necessary	Identification of a critical aspartate residue in transmembrane domain three necessary for the binding of somatostatin to the somatostatin receptor SSTR2 .
7518495	0	somatostatin	43,55	SSTR2	74,79	somatostatin	SSTR2	MESH:D013004	20606(Tax:10090)	Chemical	Gene	subtype|compound|START_ENTITY subtype|appos|END_ENTITY	Immunological detection of isoforms of the somatostatin receptor subtype , SSTR2 .
7585646	0	somatostatin	27,39	SSTR2	49,54	somatostatin	SSTR2	MESH:D013004	6752	Chemical	Gene	receptor|compound|START_ENTITY cross-reacts|nmod|receptor END_ENTITY|nsubj|cross-reacts	Morphine cross-reacts with somatostatin receptor SSTR2 in the T47D human breast_cancer cell line and decreases cell growth .
7878022	0	somatostatin	40,52	SSTR2	115,120	somatostatin	SSTR2	MESH:D013004	6752	Chemical	Gene	RC-160|compound|START_ENTITY proliferation|nmod|RC-160 Inhibition|nmod|proliferation mediated|nsubjpass|Inhibition mediated|nmod|END_ENTITY	Inhibition of cell proliferation by the somatostatin analogue RC-160 is mediated by somatostatin receptor subtypes SSTR2 and SSTR5 through different mechanisms .
7882976	0	somatostatin	137,149	SSTR2	131,136	somatostatin	SSTR2	MESH:D013004	6752	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Two amino_acids , located in transmembrane domains VI and VII , determine the selectivity of the peptide agonist SMS 201-995 for the SSTR2 somatostatin receptor .
7910018	0	somatostatin	18,30	SSTR2	48,53	somatostatin	SSTR2	MESH:D013004	6752	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Transfected human somatostatin receptor type 2 , SSTR2 , not only inhibits adenylate cyclase but also stimulates phospholipase C and Ca2 + mobilization .
7914078	0	somatostatin	6,18	SSTR2	29,34	somatostatin	SSTR2	MESH:D013004	6752	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Human somatostatin receptor , SSTR2 , is coupled to adenylyl cyclase in the presence of Gi alpha 1 protein .
7982482	0	somatostatin	106,118	SSTR2	30,35	somatostatin	SSTR2	MESH:D013004	6752	Chemical	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Somatostatin receptor subtype SSTR2 mediates the inhibition of high-voltage-activated calcium channels by somatostatin and its analogue SMS_201-995 .
8096694	0	somatostatin	14,26	SSTR2	8,13	somatostatin	SSTR2	MESH:D013004	54305(Tax:10116)	Chemical	Gene	subtype|compound|START_ENTITY subtype|nummod|END_ENTITY	The rat SSTR2 somatostatin receptor subtype is coupled to inhibition of cyclic_AMP accumulation .
8866248	0	somatostatin	14,26	SSTR2	100,105	somatostatin	SSTR2	MESH:D013004	6752	Chemical	Gene	receptor|compound|START_ENTITY Expression|nmod|receptor subtypes|nsubj|Expression subtypes|nmod|pituitary_adenomas pituitary_adenomas|dep|analysis analysis|nmod|mRNA mRNA|compound|END_ENTITY	Expression of somatostatin receptor -LRB- SSTR -RRB- subtypes in pituitary_adenomas : quantitative analysis of SSTR2 mRNA by reverse transcription-polymerase chain reaction .
7832807	0	somatostatin	60,72	SSTR4	88,93	somatostatin	SSTR4	MESH:D013004	25555(Tax:10116)	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Characterization of the proximal promoter region of the rat somatostatin receptor gene , SSTR4 .
8175684	0	somatostatin	50,62	SSTR4	23,28	somatostatin	SSTR4	MESH:D013004	25555(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|appos|receptor	Functional coupling of SSTR4 , a major hippocampal somatostatin receptor , to adenylate cyclase inhibition , arachidonate release and activation of the mitogen-activated protein kinase cascade .
9080463	0	somatostatin	27,39	SSTR4	66,71	somatostatin	SSTR4	MESH:D013004	25555(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY expression|nmod|receptors expression|parataxis|expressed expressed|nsubjpass|END_ENTITY	Differential expression of somatostatin receptors in the rat eye : SSTR4 is intensely expressed in the iris/ciliary body .
8690197	0	somatostatin	41,53	Somatostatin_receptor_subtype_2	0,31	somatostatin	Somatostatin receptor subtype 2	MESH:D013004	54305(Tax:10116)	Chemical	Gene	inhibition|compound|START_ENTITY mediates|dobj|inhibition mediates|nsubj|END_ENTITY	Somatostatin_receptor_subtype_2 mediates somatostatin inhibition of ion secretion in rat distal colon .
10698172	0	somatostatin	24,36	Sst1	19,23	somatostatin	Sst1	MESH:D013004	112256(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Involvement of the Sst1 somatostatin receptor subtype in the intrahypothalamic neuronal network regulating growth_hormone secretion : an in vitro and in vivo antisense study .
304425	0	somatostatin	10,22	VIII	65,69	somatostatin	VIII	MESH:D013004	1351	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of somatostatin on platelet_aggregation and plasma factor VIII level in normal man .
2465985	0	somatostatin	188,200	VIP	202,205	somatostatin	VIP	MESH:D013004	7432	Chemical	Gene	neurotensin|dep|START_ENTITY neurotensin|dep|END_ENTITY	Chronic_pancreatitis and diabetes_mellitus : plasma and gastroduodenal_mucosal profiles of regulatory peptides -LRB- gastrin , motilin , secretin , cholecystokinin , gastric inhibitory polypeptide , somatostatin , VIP , substance_P , pancreatic_polypeptide , glucagon , enteroglucagon , neurotensin -RRB- .
2477154	0	somatostatin	23,35	VIP	48,51	somatostatin	VIP	MESH:D013004	396323(Tax:9031)	Chemical	Gene	START_ENTITY|dep|- -|compound|END_ENTITY	Distribution of CGRP - , somatostatin - , galanin - , VIP - , and substance P-immunoreactive nerve fibers in the chicken carotid body .
7683399	0	somatostatin	26,38	VIP	75,78	somatostatin	VIP	MESH:D013004	100500718	Chemical	Gene	Release|nmod|START_ENTITY Release|appos|vasoactive_intestinal_polypeptide vasoactive_intestinal_polypeptide|appos|END_ENTITY	Release of immunoreactive somatostatin , vasoactive_intestinal_polypeptide -LRB- VIP -RRB- , and galanin during propulsive complexes in isolated pig ileum .
19637311	0	somatostatin	57,69	ZAC1	6,10	somatostatin	ZAC1	MESH:D013004	5325	Chemical	Gene	associated|xcomp|START_ENTITY associated|nsubjpass|expression expression|compound|END_ENTITY	Tumor ZAC1 expression is associated with the response to somatostatin analog therapy in patients with acromegaly .
6125538	0	somatostatin	21,33	angiotensin_II	65,79	somatostatin	angiotensin II	MESH:D013004	24179(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|response response|nmod|END_ENTITY	Inhibitory effect of somatostatin on the aldosterone response to angiotensin_II : in vitro studies .
6243130	0	somatostatin	35,47	beta-endorphin	7,21	somatostatin	beta-endorphin	MESH:D013004	5443	Chemical	Gene	responses|nmod|START_ENTITY responses|amod|END_ENTITY	Plasma beta-endorphin responses to somatostatin , thyrotropin-releasing hormone , or vasopressin in Nelson 's _ syndrome .
1364072	0	somatostatin	19,31	calcitonin	35,45	somatostatin	calcitonin	MESH:D013004	24241(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|secretion secretion|compound|END_ENTITY	Inhibitory role of somatostatin on calcitonin secretion .
2434236	0	somatostatin	128,140	calcitonin_gene-related_peptide	43,74	somatostatin	calcitonin gene-related peptide	MESH:D013004	24241(Tax:10116)	Chemical	Gene	galanin|dep|START_ENTITY substance|dep|galanin showing|nmod|substance showing|dobj|immunoreactivity immunoreactivity|amod|END_ENTITY	Primary sensory neurons of the rat showing calcitonin_gene-related_peptide immunoreactivity and their relation to substance P - , somatostatin - , galanin - , vasoactive_intestinal_polypeptide - and cholecystokinin-immunoreactive ganglion cells .
2466638	0	somatostatin	118,130	calcitonin_gene-related_peptide	58,89	somatostatin	calcitonin gene-related peptide	MESH:D013004	24241(Tax:10116)	Chemical	Gene	circulating|dobj|START_ENTITY involvement|acl|circulating Inhibition|dep|involvement Inhibition|nmod|secretion secretion|nmod|rat rat|nmod|END_ENTITY	Inhibition of pancreatic exocrine secretion in the rat by calcitonin_gene-related_peptide : involvement of circulating somatostatin .
1678197	0	somatostatin	50,62	cholecystokinin	8,23	somatostatin	cholecystokinin	MESH:D013004	25298(Tax:10116)	Chemical	Gene	control|nmod|START_ENTITY END_ENTITY|nmod|control	Role of cholecystokinin in the control of gastric somatostatin in the rat : in vivo and in vitro studies .
8764194	0	somatostatin	49,61	cholecystokinin	83,98	somatostatin	cholecystokinin	MESH:D013004	885	Chemical	Gene	secretion|compound|START_ENTITY Linkage|nmod|secretion Linkage|acl|induced induced|nmod|END_ENTITY	Linkage of -LSB- Ca2 + -RSB- i in single isolated D cells to somatostatin secretion induced by cholecystokinin .
1354012	0	somatostatin	49,61	cortico-releasing_factor	23,47	somatostatin	cortico-releasing factor	MESH:D013004	81648(Tax:10116)	Chemical	Gene	changes|appos|START_ENTITY changes|nmod|END_ENTITY	Age-related changes in cortico-releasing_factor , somatostatin , neuropeptide Y , methionine_enkephalin and beta-endorphin in specific rat brain areas .
7942060	0	somatostatin	79,91	corticotropin-releasing_factor	39,69	somatostatin	corticotropin-releasing factor	MESH:D013004	81648(Tax:10116)	Chemical	Gene	releases|dobj|START_ENTITY releases|nsubj|END_ENTITY	Intracerebroventricularly administered corticotropin-releasing_factor releases somatostatin through a cholinergic , vagal pathway in freely fed rats .
23077183	0	somatostatin	76,88	cytochrome_P450	53,68	somatostatin	cytochrome P450	MESH:D013004	4051	Chemical	Gene	analog|compound|START_ENTITY END_ENTITY|nmod|analog	Noncanonical suppression of GH-dependent isoforms of cytochrome_P450 by the somatostatin analog octreotide .
1977188	0	somatostatin	63,75	epidermal_growth_factor	96,119	somatostatin	epidermal growth factor	MESH:D013004	1950	Chemical	Gene	START_ENTITY|nmod|secretion secretion|nmod|END_ENTITY	Role of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- and endogenous somatostatin on the secretion of epidermal_growth_factor -LRB- EGF -RRB- : studies on duodenal tissue cultures .
15659806	0	somatostatin	45,57	eta	32,35	somatostatin	eta	MESH:D013004	1909	Chemical	Gene	inhibition|compound|START_ENTITY mediates|dobj|inhibition mediates|nsubj|END_ENTITY	The phosphotyrosine_phosphatase eta mediates somatostatin inhibition of glioma proliferation via the dephosphorylation of ERK1/2 .
2460071	0	somatostatin	122,134	gamma-MSH	85,94	somatostatin	gamma-MSH	MESH:D013004	5443	Chemical	Gene	VIP|appos|START_ENTITY VIP|appos|END_ENTITY	Immunohistochemical studies of the neurochemical markers , CGRP , enkephalin , galanin , gamma-MSH , NPY , PHI , proctolin , PTH , somatostatin , SP , VIP , tyrosine hydroxylase and neurofilament in nerves and cells of the human attached_gingiva .
1031795	0	somatostatin	14,26	gastrin	43,50	somatostatin	gastrin	MESH:D013004	2520	Chemical	Gene	Influence|nmod|START_ENTITY END_ENTITY|nsubj|Influence	-LSB- Influence of somatostatin -LRB- GIF -RRB- and human gastrin I on the lower esophageal sphincter -RSB- .
10403509	0	somatostatin	61,73	gastrin	34,41	somatostatin	gastrin	MESH:D013004	25320(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY subtype|nsubj|receptor subtype|dep|Effect Effect|nmod|END_ENTITY	Effect of intragastric ammonia on gastrin - , somatostatin-and somatostatin receptor subtype 2 positive-cells in rat antral mucosa .
1357547	0	somatostatin	53,65	gastrin	115,122	somatostatin	gastrin	MESH:D013004	2520	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|transcription transcription|compound|END_ENTITY	Identification of a cis-regulatory element mediating somatostatin inhibition of epidermal_growth_factor-stimulated gastrin gene transcription .
15074389	0	somatostatin	70,82	gastrin	25,32	somatostatin	gastrin	MESH:D013004	445524(Tax:9823)	Chemical	Gene	secretion|compound|START_ENTITY secretion|nmod|secretion secretion|compound|END_ENTITY	Cholecystokinin inhibits gastrin secretion independently of paracrine somatostatin secretion in the pig .
1706149	0	somatostatin	21,33	gastrin	79,86	somatostatin	gastrin	MESH:D013004	25320(Tax:10116)	Chemical	Gene	antibody|compound|START_ENTITY Effect|nmod|antibody fragments|nsubj|Effect fragments|nmod|release release|compound|END_ENTITY	Effect of a purified somatostatin monoclonal antibody and its Fab fragments on gastrin release .
1976561	0	somatostatin	39,51	gastrin	8,15	somatostatin	gastrin	MESH:D013004	25320(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY Role|nmod|release Role|nmod|END_ENTITY	Role of gastrin in bombesin-stimulated somatostatin release .
24358882	0	somatostatin	34,46	gastrin	17,24	somatostatin	gastrin	MESH:D013004	100345451(Tax:9986)	Chemical	Gene	release|compound|START_ENTITY enhances|dobj|release enhances|nsubj|END_ENTITY	Glycine-extended gastrin enhances somatostatin release from cultured rabbit fundic D-cells .
2465985	0	somatostatin	188,200	gastrin	111,118	somatostatin	gastrin	MESH:D013004	2520	Chemical	Gene	neurotensin|dep|START_ENTITY END_ENTITY|appos|neurotensin	Chronic_pancreatitis and diabetes_mellitus : plasma and gastroduodenal_mucosal profiles of regulatory peptides -LRB- gastrin , motilin , secretin , cholecystokinin , gastric inhibitory polypeptide , somatostatin , VIP , substance_P , pancreatic_polypeptide , glucagon , enteroglucagon , neurotensin -RRB- .
2563264	0	somatostatin	41,53	gastrin	14,21	somatostatin	gastrin	MESH:D013004	2520	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|expression expression|amod|END_ENTITY	Inhibition of gastrin gene expression by somatostatin .
2569233	0	somatostatin	69,81	gastrin	60,67	somatostatin	gastrin	MESH:D013004	2520	Chemical	Gene	polypeptide|dep|START_ENTITY polypeptide|compound|END_ENTITY	-LSB- Campylobacter_pylori colonization of the antrum : effect of gastrin , somatostatin , pancreatic polypeptide and neurotensin -RSB- .
2857145	0	somatostatin	53,65	gastrin	34,41	somatostatin	gastrin	MESH:D013004	25320(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|inhibition inhibition|nmod|END_ENTITY	Postreceptor inhibition of antral gastrin release by somatostatin .
2869695	0	somatostatin	72,84	gastrin	14,21	somatostatin	gastrin	MESH:D013004	25320(Tax:10116)	Chemical	Gene	mediated|nmod|START_ENTITY mediated|nsubj|Inhibition Inhibition|nmod|release release|compound|END_ENTITY	Inhibition of gastrin release by gastric_inhibitory_peptide mediated by somatostatin .
2879448	0	somatostatin	98,110	gastrin	59,66	somatostatin	gastrin	MESH:D013004	2520	Chemical	Gene	analogue|compound|START_ENTITY secretion|nmod|analogue secretion|nsubj|Characterization Characterization|nmod|inhibition inhibition|nmod|END_ENTITY	Characterization of the in vivo and in vitro inhibition of gastrin secretion from gastrinoma by a somatostatin analogue -LRB- SMS_201-995 -RRB- .
2891204	0	somatostatin	10,22	gastrin	70,77	somatostatin	gastrin	MESH:D013004	2520	Chemical	Gene	analogue|compound|START_ENTITY Effect|nmod|analogue Effect|nmod|species species|nmod|END_ENTITY	Effect of somatostatin analogue -LRB- SMS 201-995 -RRB- on molecular species of gastrin in gastrinoma .
2897057	0	somatostatin	43,55	gastrin	23,30	somatostatin	gastrin	MESH:D013004	25320(Tax:10116)	Chemical	Gene	secretion|compound|START_ENTITY secretion|compound|END_ENTITY	Effect of vitamin_D on gastrin and gastric somatostatin secretion from the isolated perfused rat stomach .
562056	0	somatostatin	47,59	gastrin	97,104	somatostatin	gastrin	MESH:D013004	25320(Tax:10116)	Chemical	Gene	ulcer|nmod|START_ENTITY ulcer|dep|failure failure|acl|suppress suppress|dobj|END_ENTITY	Anti-stress ulcer and anti-secretory effect of somatostatin in rats -- failure to suppress serum gastrin .
580834	0	somatostatin	24,36	gastrin	64,71	somatostatin	gastrin	MESH:D013004	445524(Tax:9823)	Chemical	Gene	Participation|nmod|START_ENTITY Participation|nmod|regulation regulation|nmod|release release|compound|END_ENTITY	Participation of antral somatostatin in the local regulation of gastrin release .
6103802	0	somatostatin	44,56	gastrin	11,18	somatostatin	gastrin	MESH:D013004	100685087	Chemical	Gene	pancreatic_polypeptide|compound|START_ENTITY levels|nmod|pancreatic_polypeptide circulating|dobj|levels END_ENTITY|acl|circulating	Effects of gastrin on circulating levels of somatostatin , pancreatic_polypeptide , and vasoactive intestinal peptide in dogs .
6108902	0	somatostatin	21,33	gastrin	70,77	somatostatin	gastrin	MESH:D013004	100685087	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nsubj|effect	Inhibitory effect of somatostatin on gastric_acid secretion and serum gastrin in dogs with and without duodenogastric reflux .
6111512	0	somatostatin	14,26	gastrin	56,63	somatostatin	gastrin	MESH:D013004	2520	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of somatostatin on bombesin-stimulated serum gastrin and gastric_acid secretion in man .
6120888	0	somatostatin	10,22	gastrin	78,85	somatostatin	gastrin	MESH:D013004	2520	Chemical	Gene	Effect|nmod|START_ENTITY sphincter|nsubj|Effect sphincter|dobj|END_ENTITY	Effect of somatostatin on lower esophageal sphincter -LRB- les -RRB- pressure and serum gastrin in normal and achalasic subjects .
6130796	0	somatostatin	10,22	gastrin	50,57	somatostatin	gastrin	MESH:D013004	101119230	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|concentrations concentrations|nmod|END_ENTITY	Effect of somatostatin on basal concentrations of gastrin and pancreatic_polypeptide in the fetal sheep .
6138366	0	somatostatin	57,69	gastrin	14,21	somatostatin	gastrin	MESH:D013004	25320(Tax:10116)	Chemical	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|Inhibition Inhibition|nmod|release release|compound|END_ENTITY	Inhibition of gastrin release by secretin is mediated by somatostatin in cultured rat antral mucosa .
6141932	0	somatostatin	11,23	gastrin	50,57	somatostatin	gastrin	MESH:D013004	25320(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|release release|compound|END_ENTITY	Effects of somatostatin and acid on inhibition of gastrin release in newborn rats .
7882187	0	somatostatin	96,108	gastrin	143,150	somatostatin	gastrin	MESH:D013004	25320(Tax:10116)	Chemical	Gene	secretion|compound|START_ENTITY secretion|nmod|effects effects|nmod|secretion secretion|compound|END_ENTITY	Gastric inhibitory polypeptide and glucagon-like_peptide-1 -LRB- 7-36 -RRB- amide exert similar effects on somatostatin secretion but opposite effects on gastrin secretion from the rat stomach .
8105080	0	somatostatin	82,94	gastrin	56,63	somatostatin	gastrin	MESH:D013004	2520	Chemical	Gene	insulin|dep|START_ENTITY insulin|compound|END_ENTITY	The relationships between personality traits and plasma gastrin , cholecystokinin , somatostatin , insulin , and oxytocin levels in healthy women .
836610	0	somatostatin	18,30	gastrin	40,47	somatostatin	gastrin	MESH:D013004	2520	Chemical	Gene	influence|nmod|START_ENTITY -LSB-|dobj|influence -LSB-|nmod|concentrations concentrations|compound|END_ENTITY	-LSB- The influence of somatostatin on serum gastrin concentrations in patients after total duodenopancreatectomy -LRB- author 's transl -RRB- -RSB- .
8511502	0	somatostatin	12,24	gastrin	58,65	somatostatin	gastrin	MESH:D013004	25320(Tax:10116)	Chemical	Gene	analogue|compound|START_ENTITY analogue|nmod|hyperplasia hyperplasia|compound|END_ENTITY	Effect of a somatostatin analogue -LRB- SMS_201-995 -RRB- on antral gastrin cell hyperplasia and hypergastrinemia induced by a histamine H2-receptor antagonist .
866987	0	somatostatin	14,26	gastrin	30,37	somatostatin	gastrin	MESH:D013004	2520	Chemical	Gene	START_ENTITY|nmod|release release|amod|END_ENTITY	Inhibition by somatostatin of gastrin release and gastric_acid responses to meals and to pentagastrin in man .
9160043	0	somatostatin	14,26	gastrin	61,68	somatostatin	gastrin	MESH:D013004	100685087	Chemical	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|END_ENTITY	Comparison of somatostatin and pancreastatin on secretion of gastrin , pancreatic_polypeptide , and peptide_YY .
9193776	0	somatostatin	57,69	gastrin	47,54	somatostatin	gastrin	MESH:D013004	2520	Chemical	Gene	cells|amod|START_ENTITY studies|appos|cells studies|nmod|END_ENTITY	Immunocytochemical and morphometric studies of gastrin - , somatostatin - and serotonin-producing cells in the stomach and duodenum of patients with acid peptic disorders .
9575858	0	somatostatin	28,40	gastrin	62,69	somatostatin	gastrin	MESH:D013004	101119230	Chemical	Gene	immunization|nmod|START_ENTITY alters|nsubj|immunization alters|dobj|regulation regulation|nmod|END_ENTITY	Active immunization against somatostatin alters regulation of gastrin in response to gastric_acid secretagogues .
991831	0	somatostatin	77,89	gastrin	56,63	somatostatin	gastrin	MESH:D013004	100685087	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|inhibitions inhibitions|nmod|END_ENTITY	Direct inhibitions of basal and arginine-induced plasma gastrin secretion by somatostatin in anesthetized dogs .
11834435	0	somatostatin	55,67	ghrelin	21,28	somatostatin	ghrelin	MESH:D013004	59301(Tax:10116)	Chemical	Gene	secretion|compound|START_ENTITY effect|nmod|secretion effect|nmod|END_ENTITY	Inhibitory effect of ghrelin on insulin and pancreatic somatostatin secretion .
7913983	0	somatostatin	12,24	glucagon-like_peptide-1	86,109	somatostatin	glucagon-like peptide-1	MESH:D013004	24952(Tax:10116)	Chemical	Gene	START_ENTITY|dep|interactions interactions|nmod|amide amide|amod|END_ENTITY	Rat gastric somatostatin and gastrin release : interactions of exendin-4 and truncated glucagon-like_peptide-1 -LRB- GLP-1 -RRB- amide .
24634935	0	somatostatin	22,34	glycogen_synthase_kinase-3b	107,134	somatostatin	glycogen synthase kinase-3b	MESH:D013004	2932	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Octreotide stimulates somatostatin receptor-induced apoptosis of SW480 colon_cancer cells by activation of glycogen_synthase_kinase-3b , A Wnt/b-catenin pathway modulator .
10591235	0	somatostatin	10,22	growth_hormone	62,76	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	analog|compound|START_ENTITY suppresses|nsubj|analog suppresses|ccomp|preserved preserved|nsubj|equivalently equivalently|amod|END_ENTITY	Synthetic somatostatin analog -LRB- octreotide -RRB- suppresses daytime growth_hormone secretion equivalently in young and older men : preserved pituitary responsiveness to somatostatin 's inhibition in aging .
10591235	0	somatostatin	162,174	growth_hormone	62,76	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	inhibition|nmod:poss|START_ENTITY preserved|nmod|inhibition preserved|nsubj|equivalently equivalently|amod|END_ENTITY	Synthetic somatostatin analog -LRB- octreotide -RRB- suppresses daytime growth_hormone secretion equivalently in young and older men : preserved pituitary responsiveness to somatostatin 's inhibition in aging .
10698172	0	somatostatin	24,36	growth_hormone	107,121	somatostatin	growth hormone	MESH:D013004	81668(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY Involvement|nmod|receptor subtype|nsubj|Involvement subtype|dep|regulating regulating|dobj|secretion secretion|amod|END_ENTITY	Involvement of the Sst1 somatostatin receptor subtype in the intrahypothalamic neuronal network regulating growth_hormone secretion : an in vitro and in vivo antisense study .
107024	0	somatostatin	72,84	growth_hormone	28,42	somatostatin	growth hormone	MESH:D013004	81668(Tax:10116)	Chemical	Gene	antiserum|compound|START_ENTITY Studies|nmod|antiserum Studies|nmod|mechanism mechanism|nmod|responses responses|compound|END_ENTITY	Studies on the mechanism of growth_hormone and thyrotropin responses to somatostatin antiserum in anesthetized rats .
11145612	0	somatostatin	18,30	growth_hormone	88,102	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	analog|compound|START_ENTITY analog|dep|suppression suppression|nmod|END_ENTITY	Novel long-acting somatostatin analog with endocrine selectivity : potent suppression of growth_hormone but not of insulin .
11171604	0	somatostatin	68,80	growth_hormone	14,28	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	withdrawal|compound|START_ENTITY evidence|nmod|withdrawal Generation|dep|evidence Generation|nmod|pulsatility pulsatility|amod|END_ENTITY	Generation of growth_hormone pulsatility in women : evidence against somatostatin withdrawal as pulse initiator .
1127098	0	somatostatin	40,52	growth_hormone	73,87	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|inhibiton inhibiton|nmod|Secretion Secretion|compound|END_ENTITY	Comparison of cylic and linear forms of somatostatin in the inhibiton of growth_hormone , insulin and glucagon Secretion .
11443179	0	somatostatin	75,87	growth_hormone	127,141	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	inhibition|nmod:poss|START_ENTITY inhibition|acl|fasting fasting|dobj|secretion secretion|amod|END_ENTITY	Short-term estradiol replacement in postmenopausal women selectively mutes somatostatin 's dose-dependent inhibition of fasting growth_hormone secretion .
11514055	0	somatostatin	22,34	growth_hormone	79,93	somatostatin	growth hormone	MESH:D013004	378781(Tax:9031)	Chemical	Gene	receptor|compound|START_ENTITY Identification|nmod|receptor subtypes|nsubj|Identification subtypes|xcomp|involved involved|nmod|regulation regulation|nmod|secretion secretion|amod|END_ENTITY	Identification of the somatostatin receptor subtypes involved in regulation of growth_hormone secretion in chickens .
1152345	0	somatostatin	21,33	growth_hormone	66,80	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|changes changes|nmod|END_ENTITY	Effects of synthetic somatostatin on endotoxin-induced changes of growth_hormone , cortisol and insulin in plasma , blood sugar and blood leukocytes in man .
1153917	0	somatostatin	14,26	growth_hormone	42,56	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	START_ENTITY|nmod|rise rise|nmod|secretion secretion|compound|END_ENTITY	The effect of somatostatin on the rise of growth_hormone and glucagon secretion induced by arginine and L-dopa in diabetic patients .
12115242	0	somatostatin	96,108	growth_hormone	9,23	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	tone|compound|START_ENTITY evidence|nmod|tone secretion|dep|evidence secretion|compound|END_ENTITY	Impaired growth_hormone secretion in fibromyalgia patients : evidence for augmented hypothalamic somatostatin tone .
12169771	0	somatostatin	50,62	growth_hormone	22,36	somatostatin	growth hormone	MESH:D013004	81668(Tax:10116)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|amod|END_ENTITY	Inhibitory control of growth_hormone secretion by somatostatin in rat pituitary GC cells : sst -LRB- 2 -RRB- but not sst -LRB- 1 -RRB- receptors are coupled to inhibition of single-cell intracellular free calcium concentrations .
1248667	0	somatostatin	18,30	growth_hormone	49,63	somatostatin	growth hormone	MESH:D013004	81668(Tax:10116)	Chemical	Gene	analogs|compound|START_ENTITY analogs|nmod|levels levels|compound|END_ENTITY	Inhibition by six somatostatin analogs of plasma growth_hormone levels stimulated by thiamylal and morphine in the rat .
1257793	0	somatostatin	13,25	growth_hormone	64,78	somatostatin	growth hormone	MESH:D013004	81668(Tax:10116)	Chemical	Gene	Antiserum|nmod|START_ENTITY prevents|nsubj|Antiserum prevents|dobj|inhibition inhibition|nmod|secretion secretion|amod|END_ENTITY	Antiserum to somatostatin prevents stress-induced inhibition of growth_hormone secretion in the rat .
12670836	0	somatostatin	93,105	growth_hormone	24,38	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	declines|nmod|START_ENTITY require|dobj|declines require|nsubj|secretions secretions|compound|END_ENTITY	Pulsatile and nocturnal growth_hormone secretions in men do not require periodic declines of somatostatin .
12740016	0	somatostatin	18,30	growth_hormone	53,67	somatostatin	growth hormone	MESH:D013004	378781(Tax:9031)	Chemical	Gene	Identification|nmod|START_ENTITY receptors|nsubj|Identification receptors|dobj|END_ENTITY	Identification of somatostatin receptors controlling growth_hormone and thyrotropin secretion in the chicken using receptor subtype-specific agonists .
1347739	0	somatostatin	137,149	growth_hormone	45,59	somatostatin	growth hormone	MESH:D013004	81668(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY GH|dep|role GH|amod|END_ENTITY	Time-dependent reduction and potentiation of growth_hormone -LRB- GH -RRB- responsiveness to GH-releasing_factor induced by exogenous GH : role for somatostatin .
1347904	0	somatostatin	138,150	growth_hormone	88,102	somatostatin	growth hormone	MESH:D013004	81668(Tax:10116)	Chemical	Gene	tone|compound|START_ENTITY conditions|nmod|tone secretion|nmod|conditions secretion|amod|END_ENTITY	Effects of passive immunization of growth_hormone-releasing_hormone and somatostatin on growth_hormone secretion under conditions of high somatostatin tone .
1348664	0	somatostatin	104,116	growth_hormone	23,37	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	secretion|nmod|START_ENTITY END_ENTITY|nsubj|secretion	Half-life of exogenous growth_hormone following suppression of endogenous growth_hormone secretion with somatostatin in type_I _ -LRB- insulin-dependent -RRB- _ diabetes_mellitus .
1348664	0	somatostatin	104,116	growth_hormone	74,88	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	secretion|nmod|START_ENTITY secretion|amod|END_ENTITY	Half-life of exogenous growth_hormone following suppression of endogenous growth_hormone secretion with somatostatin in type_I _ -LRB- insulin-dependent -RRB- _ diabetes_mellitus .
1350760	0	somatostatin	78,90	growth_hormone	31,45	somatostatin	growth hormone	MESH:D013004	81668(Tax:10116)	Chemical	Gene	attenuates|nmod|START_ENTITY attenuates|dobj|secretion secretion|compound|END_ENTITY	Tamoxifen attenuates pulsatile growth_hormone secretion : mediation in part by somatostatin .
1356837	0	somatostatin	64,76	growth_hormone	80,94	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	START_ENTITY|nmod|metabolite metabolite|amod|END_ENTITY	Different effects of growth_hormone-releasing_hormone -LRB- GRH -RRB- and somatostatin on growth_hormone and stable metabolite of prostaglandin_E2 , _ 13 , _ 14-dihydro-15-keto-prostaglandin_E2 -LRB- PGE2-M -RRB- in normal subjects .
14715838	0	somatostatin	153,165	growth_hormone	82,96	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	infusion|nmod|START_ENTITY triggered|nmod|infusion END_ENTITY|acl|triggered	Estradiol supplementation in postmenopausal women doubles rebound-like release of growth_hormone -LRB- GH -RRB- triggered by sequential infusion and withdrawal of somatostatin : evidence that estrogen facilitates endogenous GH-releasing hormone drive .
15070915	0	somatostatin	10,22	growth_hormone	81,95	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	SOM230|compound|START_ENTITY inhibitor|nsubj|SOM230 inhibitor|nmod|release release|nmod|pituitary_adenomas pituitary_adenomas|amod|END_ENTITY	The novel somatostatin analog SOM230 is a potent inhibitor of hormone release by growth_hormone - and prolactin-secreting pituitary_adenomas in vitro .
15153755	0	somatostatin	99,111	growth_hormone	18,32	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	tone|compound|START_ENTITY combined|nmod|tone effect|acl|combined secretion|nmod|effect secretion|amod|END_ENTITY	Leptin stimulates growth_hormone secretion via a direct pituitary effect combined with a decreased somatostatin tone in a median eminence-pituitary perifusion study .
1516889	0	somatostatin	18,30	growth_hormone	54,68	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	analogue|compound|START_ENTITY effect|nmod|analogue octreotide|nsubj|effect octreotide|nmod|secretion secretion|amod|END_ENTITY	The effect of the somatostatin analogue octreotide on growth_hormone secretion in insulin-dependent diabetics without residual insulin secretion .
15625860	0	somatostatin	45,57	growth_hormone	70,84	somatostatin	growth hormone	MESH:D013004	81668(Tax:10116)	Chemical	Gene	analog|nmod|START_ENTITY Synthesis|nmod|analog Synthesis|acl|having having|dobj|release release|amod|END_ENTITY	Synthesis of a nonreducible cyclic analog of somatostatin having only growth_hormone release inhibiting activity .
15943838	0	somatostatin	90,102	growth_hormone	10,24	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	therapy|compound|START_ENTITY efficacy|nmod|therapy predicts|dobj|efficacy END_ENTITY|advcl|predicts	The nadir growth_hormone after an octreotide test dose predicts the long-term efficacy of somatostatin analogue therapy in acromegaly .
16537682	0	somatostatin	64,76	growth_hormone	20,34	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	withdrawal|compound|START_ENTITY driven|nmod|withdrawal secretion|acl|driven secretion|amod|END_ENTITY	Ghrelin potentiates growth_hormone secretion driven by putative somatostatin withdrawal and resists inhibition by human corticotropin-releasing_hormone .
1671874	0	somatostatin	48,60	growth_hormone	81,95	somatostatin	growth hormone	MESH:D013004	81668(Tax:10116)	Chemical	Gene	cells|nmod|START_ENTITY Pre-exposure|nmod|cells enhances|nsubj|Pre-exposure enhances|dobj|secretion secretion|compound|END_ENTITY	Pre-exposure of rat anterior pituitary cells to somatostatin enhances subsequent growth_hormone secretion .
16720722	0	somatostatin	19,31	growth_hormone	104,118	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	mimics|dobj|START_ENTITY mimics|advcl|inducing inducing|nmod|secretion secretion|amod|END_ENTITY	Cortistatin mimics somatostatin by inducing a dual , dose-dependent stimulatory and inhibitory effect on growth_hormone secretion in somatotropes .
16728386	0	somatostatin	137,149	growth_hormone	19,33	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	withdrawal|compound|START_ENTITY administration|nmod|withdrawal analogue|dobj|administration analogue|nsubj|Disappearance Disappearance|nmod|adenoma adenoma|amod|END_ENTITY	Disappearance of a growth_hormone secreting macro adenoma during long-term somatostatin analogue administration and recurrence following somatostatin withdrawal .
16728386	0	somatostatin	75,87	growth_hormone	19,33	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	adenoma|nmod|START_ENTITY adenoma|amod|END_ENTITY	Disappearance of a growth_hormone secreting macro adenoma during long-term somatostatin analogue administration and recurrence following somatostatin withdrawal .
1674685	0	somatostatin	21,33	growth_hormone	108,122	somatostatin	growth hormone	MESH:D013004	81668(Tax:10116)	Chemical	Gene	dimorphism|nmod|START_ENTITY dimorphism|acl|signaling signaling|nmod|control control|nmod|secretion secretion|compound|END_ENTITY	Sexual dimorphism of somatostatin and growth_hormone-releasing_factor signaling in the control of pulsatile growth_hormone secretion in the rat .
1682193	0	somatostatin	42,54	growth_hormone	14,28	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Resistance Resistance|nmod|END_ENTITY	Resistance of growth_hormone secretion to somatostatin in men with type_I_diabetes_mellitus .
1692988	0	somatostatin	39,51	growth_hormone	75,89	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Evidence for involvement of endogenous somatostatin in the galanin-induced growth_hormone secretion in children .
17341555	0	somatostatin	81,93	growth_hormone	106,120	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	blockade|compound|START_ENTITY blockade|nmod|END_ENTITY	Dose-response effects of free fatty_acids on glucose and lipid metabolism during somatostatin blockade of growth_hormone and insulin in humans .
174366	0	somatostatin	72,84	growth_hormone	19,33	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|stimulation stimulation|nmod|END_ENTITY	The stimulation of growth_hormone release by ACTH and its inhibition by somatostatin .
17473207	0	somatostatin	14,26	growth_hormone	75,89	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	analogue|compound|START_ENTITY SOM230|appos|analogue effective|nsubj|SOM230 effective|nmod|therapy therapy|nmod|pituitary_adenomas pituitary_adenomas|amod|END_ENTITY	SOM230 , a new somatostatin analogue , is highly effective in the therapy of growth_hormone / prolactin-secreting pituitary_adenomas .
1867112	0	somatostatin	24,36	growth_hormone	65,79	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	analogue|compound|START_ENTITY analogue|nmod|END_ENTITY	Effect of a long-acting somatostatin analogue -LRB- SMS 201-995 -RRB- on a growth_hormone and thyroid stimulating hormone-producing pituitary_tumor .
19215388	0	somatostatin	11,23	growth_hormone	71,85	somatostatin	growth hormone	MESH:D013004	81668(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of somatostatin on the growth_hormone-releasing factor-induced growth_hormone secretion in rats with electrical and chemical inhibitions of endogenous growth_hormone-releasing factor and somatostatin .
1971827	0	somatostatin	83,95	growth_hormone	25,39	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	infusion|compound|START_ENTITY concentrations|nmod|infusion concentrations|nmod|END_ENTITY	Plasma concentrations of growth_hormone during hyperglycemic clamp with or without somatostatin infusion in obese subjects .
1973122	0	somatostatin	121,133	growth_hormone	40,54	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	analogue|compound|START_ENTITY comparison|nmod|analogue comparison|nmod|effectiveness effectiveness|nmod|suppression suppression|amod|END_ENTITY	A comparison among the effectiveness of growth_hormone suppression in active acromegaly of bromocriptine and long acting somatostatin analogue -LRB- SMS_201-995 -RRB- .
1977761	0	somatostatin	131,143	growth_hormone	40,54	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	release|compound|START_ENTITY inhibition|nmod|release enhances|nmod|inhibition enhances|dobj|response response|compound|END_ENTITY	Alpha 2-adrenergic agonism enhances the growth_hormone -LRB- GH -RRB- response to GH-releasing hormone through an inhibition of hypothalamic somatostatin release in normal men .
23574573	0	somatostatin	110,122	growth_hormone	11,25	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	analogues|compound|START_ENTITY treatment|nmod|analogues responses|nmod|treatment Control|dep|responses Control|nmod|END_ENTITY	Control of growth_hormone and IGF1 in patients with acromegaly in the UK : responses to medical treatment with somatostatin analogues and dopamine agonists .
2506217	0	somatostatin	4,16	growth_hormone	61,75	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	octreotide|compound|START_ENTITY inhibits|nsubj|octreotide inhibits|dep|releasing releasing|nsubj|secretion secretion|nmod|END_ENTITY	The somatostatin analog octreotide inhibits the secretion of growth_hormone -LRB- GH -RRB- - releasing hormone , thyrotropin , and GH in man .
2537844	0	somatostatin	80,92	growth_hormone	4,18	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	correlate|nmod|START_ENTITY status|amod|correlate octreotide|nmod|status responses|xcomp|octreotide responses|nsubj|END_ENTITY	The growth_hormone responses to octreotide in acromegaly correlate with adenoma somatostatin receptor status .
25535518	0	somatostatin	66,78	growth_hormone	106,120	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	combination|nmod|START_ENTITY surgery|nmod|combination Outcome|nmod|surgery analogues|nsubj|Outcome analogues|nmod|patients patients|nmod|pituitary_adenoma pituitary_adenoma|compound|END_ENTITY	Outcome of endoscopic transsphenoidal surgery in combination with somatostatin analogues in patients with growth_hormone producing pituitary_adenoma .
2563681	2	somatostatin	69,81	growth_hormone	89,103	somatostatin	growth hormone	MESH:D013004	443329(Tax:9940)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|response response|amod|END_ENTITY	The effect of somatostatin on the growth_hormone -LRB- GH -RRB- response to GH-releasing factor .
2563730	0	somatostatin	15,27	growth_hormone	65,79	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	analog|compound|START_ENTITY Effects|nmod|analog BIM_23014|nsubj|Effects BIM_23014|nmod|secretion secretion|nmod|thyrotropin thyrotropin|compound|END_ENTITY	Effects of the somatostatin analog BIM_23014 on the secretion of growth_hormone , thyrotropin , and digestive peptides in normal men .
2563734	0	somatostatin	151,163	growth_hormone	24,38	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	secretion|nmod|START_ENTITY GH|acl|secretion stimulation|nmod|GH man|nmod|stimulation disappearance|nmod|man END_ENTITY|xcomp|disappearance	Half-time of endogenous growth_hormone -LRB- GH -RRB- disappearance in normal man after stimulation of GH secretion by GH-releasing hormone and suppression with somatostatin .
2574646	0	somatostatin	104,116	growth_hormone	27,41	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	growth_hormone|nmod|START_ENTITY END_ENTITY|advcl|growth_hormone	The half-life of exogenous growth_hormone after suppression of endogenous growth_hormone secretion with somatostatin .
26115707	0	somatostatin	88,100	growth_hormone	61,75	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	analogs|compound|START_ENTITY response|nmod|analogs response|amod|END_ENTITY	Impact of gsp mutations in somatotroph pituitary adenomas on growth_hormone response to somatostatin analogs : a meta-analysis .
26391562	0	somatostatin	13,25	growth_hormone	108,122	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	receptor|compound|START_ENTITY receptor|dep|expression expression|nmod|pituitary_tumors pituitary_tumors|amod|END_ENTITY	Differential somatostatin receptor -LRB- SSTR -RRB- 1-5 expression and downstream effectors in histologic subtypes of growth_hormone pituitary_tumors .
2857511	0	somatostatin	10,22	growth_hormone	26,40	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	START_ENTITY|nmod|response response|compound|END_ENTITY	Effect of somatostatin on growth_hormone and prolactin response to dermorphin in man .
2861154	0	somatostatin	20,32	growth_hormone	44,58	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|secretion secretion|amod|END_ENTITY	Interaction between somatostatin and TRH on growth_hormone secretion in perifused human growth_hormone tumor cells .
2861154	0	somatostatin	20,32	growth_hormone	88,102	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|cells cells|compound|END_ENTITY	Interaction between somatostatin and TRH on growth_hormone secretion in perifused human growth_hormone tumor cells .
2862011	0	somatostatin	14,26	growth_hormone	90,104	somatostatin	growth hormone	MESH:D013004	81668(Tax:10116)	Chemical	Gene	Modulation|nmod|START_ENTITY binding|nsubj|Modulation binding|xcomp|rat rat|nmod|END_ENTITY	Modulation of somatostatin binding to rat pituitary membranes by exogenously administered growth_hormone .
2862015	0	somatostatin	96,108	growth_hormone	49,63	somatostatin	growth hormone	MESH:D013004	81668(Tax:10116)	Chemical	Gene	part|nmod|START_ENTITY mediation|nmod|part Effects|dep|mediation Effects|nmod|glucopenia glucopenia|nmod|secretion secretion|compound|END_ENTITY	Effects of intracellular glucopenia on pulsatile growth_hormone secretion : mediation in part by somatostatin .
2862016	0	somatostatin	13,25	growth_hormone	54,68	somatostatin	growth hormone	MESH:D013004	81668(Tax:10116)	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|dobj|suppression suppression|nmod|secretion secretion|amod|END_ENTITY	Hypothalamic somatostatin mediates the suppression of growth_hormone secretion by centrally administered thyrotropin-releasing_hormone in conscious rats .
2862018	0	somatostatin	100,112	growth_hormone	24,38	somatostatin	growth hormone	MESH:D013004	81668(Tax:10116)	Chemical	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|inhibition inhibition|nmod|secretion secretion|amod|END_ENTITY	Prolonged inhibition of growth_hormone secretion by peripheral injection of bombesin is mediated by somatostatin in the rat .
2864652	0	somatostatin	135,147	growth_hormone	7,21	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	administered|nmod|START_ENTITY rats|acl|administered growth_hormone_releasing_factor|nmod|rats END_ENTITY|nmod|growth_hormone_releasing_factor	Plasma growth_hormone response to human growth_hormone_releasing_factor in rats administered with chlorpromazine and antiserum against somatostatin .
2865691	0	somatostatin	28,40	growth_hormone	63,77	somatostatin	growth hormone	MESH:D013004	81668(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|suppression suppression|nmod|END_ENTITY	Involvement of hypothalamic somatostatin in the suppression of growth_hormone secretion by central corticotropin-releasing_factor in conscious male rats .
2866085	0	somatostatin	77,89	growth_hormone	20,34	somatostatin	growth hormone	MESH:D013004	81668(Tax:10116)	Chemical	Gene	factor|compound|START_ENTITY role|nmod|factor role|nmod|mechanism mechanism|nmod|regulation regulation|amod|END_ENTITY	On the mechanism of growth_hormone autofeedback regulation : possible role of somatostatin and growth_hormone-releasing factor .
2869424	0	somatostatin	58,70	growth_hormone	14,28	somatostatin	growth hormone	MESH:D013004	81668(Tax:10116)	Chemical	Gene	systems|compound|START_ENTITY secretion|nmod|systems secretion|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of growth_hormone and thyrotropin secretion by somatostatin systems in rat brain .
2870913	0	somatostatin	38,50	growth_hormone	163,177	somatostatin	growth hormone	MESH:D013004	81668(Tax:10116)	Chemical	Gene	fate|nmod|START_ENTITY has|nmod|fate has|dobj|effects effects|nmod|secretion secretion|amod|END_ENTITY	On the fate of centrally administered somatostatin in the rat : massive hypersomatostatinemia resulting from leakage into the peripheral circulation has effects on growth_hormone secretion and glucoregulation .
2878748	0	somatostatin	65,77	growth_hormone	19,33	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	SMS_201-995|compound|START_ENTITY secretion|nmod|SMS_201-995 secretion|nsubj|sensitivity sensitivity|nmod|END_ENTITY	The sensitivity of growth_hormone and prolactin secretion to the somatostatin analogue SMS_201-995 in patients with prolactinomas and acromegaly .
2878963	0	somatostatin	152,164	growth_hormone	54,68	somatostatin	growth hormone	MESH:D013004	81668(Tax:10116)	Chemical	Gene	modulate|nmod|START_ENTITY modulate|dobj|response response|amod|END_ENTITY	Cholinergic agonist and antagonist drugs modulate the growth_hormone response to growth_hormone-releasing hormone in the rat : evidence for mediation by somatostatin .
2881841	0	somatostatin	177,189	growth_hormone	193,207	somatostatin	growth hormone	MESH:D013004	378781(Tax:9031)	Chemical	Gene	START_ENTITY|nmod|release release|amod|END_ENTITY	Growth_hormone secretion from chicken adenohypophyseal cells in primary culture : effects of human pancreatic growth_hormone-releasing factor , thyrotropin-releasing_hormone , and somatostatin on growth_hormone release .
2882822	0	somatostatin	104,116	growth_hormone	60,74	somatostatin	growth hormone	MESH:D013004	81668(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Involvement Involvement|nmod|mechanisms mechanisms|nmod|secretion secretion|amod|END_ENTITY	Involvement of alpha-adrenergic and GABAergic mechanisms in growth_hormone secretion induced by central somatostatin in rats .
2883595	0	somatostatin	21,33	growth_hormone	106,120	somatostatin	growth hormone	MESH:D013004	81668(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY infusions|nsubj|Effect infusions|nmod|response response|amod|END_ENTITY	Effect of continuous somatostatin and growth_hormone-releasing_hormone -LRB- GHRH -RRB- infusions on the subsequent growth_hormone -LRB- GH -RRB- response to GHRH .
2886202	0	somatostatin	58,70	growth_hormone	85,99	somatostatin	growth hormone	MESH:D013004	81668(Tax:10116)	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|secretion secretion|amod|END_ENTITY	Cycloheximide_blocks_insulin-like_growth factor I but not somatostatin inhibition of growth_hormone secretion .
2891721	0	somatostatin	24,36	growth_hormone	96,110	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|secretion secretion|nmod|END_ENTITY	Differential effects of somatostatin -LRB- SRIH -RRB- and a SRIH analog , SMS_201-995 , on the secretion of growth_hormone and thyroid-stimulating hormone in man .
2894294	0	somatostatin	115,127	growth_hormone	25,39	somatostatin	growth hormone	MESH:D013004	443329(Tax:9940)	Chemical	Gene	immunization|nmod|START_ENTITY Changes|nmod|immunization Changes|nmod|levels levels|nmod|END_ENTITY	Changes in the levels of growth_hormone , insulin , somatomedin_C and thyroxine in sheep during immunization against somatostatin .
2901338	0	somatostatin	35,47	growth_hormone	75,89	somatostatin	growth hormone	MESH:D013004	81668(Tax:10116)	Chemical	Gene	RC-160|compound|START_ENTITY formulation|nmod|RC-160 inhibits|nsubj|formulation inhibits|dobj|response response|compound|END_ENTITY	Delayed release formulation of the somatostatin analog RC-160 inhibits the growth_hormone -LRB- GH -RRB- response to GH-releasing factor - -LRB- 1-29 -RRB- NH2 and decreases elevated prolactin levels in rats .
2901739	0	somatostatin	33,45	growth_hormone	103,117	somatostatin	growth hormone	MESH:D013004	81668(Tax:10116)	Chemical	Gene	Identification|nmod|START_ENTITY Identification|dep|regulation regulation|nmod|blockers blockers|amod|content content|nmod|agonists agonists|amod|END_ENTITY	Identification of immunoreactive somatostatin in the rat harderian gland : regulation of its content by growth_hormone , beta-adrenergic agonists and calcium channel blockers .
2907614	0	somatostatin	24,36	growth_hormone	142,156	somatostatin	growth hormone	MESH:D013004	81668(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY reduction|nmod|concentration interacted|nsubj|reduction interacted|xcomp|titrate titrate|dobj|magnitude magnitude|nmod|END_ENTITY	Fractional reduction of somatostatin concentration interacted with rat growth_hormone_releasing_hormone to titrate the magnitude of pulsatile growth_hormone and prolactin release in perifusion .
4549923	0	somatostatin	32,44	growth_hormone	112,126	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	potency|nmod|START_ENTITY potency|nmod|END_ENTITY	Biological potency of synthetic somatostatin in the oxidized and reduced form on the inhibition of secretion of growth_hormone .
476984	0	somatostatin	10,22	growth_hormone	35,49	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of somatostatin on abnormal growth_hormone and prolactin secretion in patients with the carcinoid_syndrome .
6114854	0	somatostatin	64,76	growth_hormone	11,25	somatostatin	growth hormone	MESH:D013004	81668(Tax:10116)	Chemical	Gene	content|compound|START_ENTITY Effects|nmod|content Effects|nmod|excess excess|amod|END_ENTITY	Effects of growth_hormone excess and deficiency on hypothalamic somatostatin content and release and on tissue somatostatin distribution .
6117462	0	somatostatin	10,22	growth_hormone	113,127	somatostatin	growth hormone	MESH:D013004	81668(Tax:10116)	Chemical	Gene	release|nsubj|START_ENTITY release|nmod|levels levels|compound|END_ENTITY	Pulsatile somatostatin release from the median eminence of the unanesthetized rat and its relationship to plasma growth_hormone levels .
6118262	0	somatostatin	54,66	growth_hormone	28,42	somatostatin	growth hormone	MESH:D013004	81668(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY release|amod|stimulates stimulates|amod|END_ENTITY	Intraventricularly injected growth_hormone stimulates somatostatin release into rat hypophysial portal blood .
6120074	0	somatostatin	24,36	growth_hormone	40,54	somatostatin	growth hormone	MESH:D013004	81668(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Influence of endogenous somatostatin on growth_hormone and thyrotropin secretion in neonatal rats .
6129681	0	somatostatin	28,40	growth_hormone	98,112	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	inhibition|compound|START_ENTITY Differentiation|nmod|inhibition observed|nsubj|Differentiation observed|nmod|secretion secretion|amod|END_ENTITY	Differentiation between the somatostatin inhibition and the post-somatostatin rebound observed on growth_hormone secretion in vitro .
6137127	0	somatostatin	65,77	growth_hormone	15,29	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	dose|nmod|START_ENTITY Changes|nmod|dose Changes|nmod|level level|amod|END_ENTITY	Changes of the growth_hormone level after a single small dose of somatostatin .
6143604	0	somatostatin	76,88	growth_hormone	20,34	somatostatin	growth hormone	MESH:D013004	403795(Tax:9615)	Chemical	Gene	withdrawal|compound|START_ENTITY initiated|nmod|withdrawal initiated|nsubjpass|bursts bursts|nmod|secretion secretion|amod|END_ENTITY	Secretory bursts of growth_hormone secretion in the dog may be initiated by somatostatin withdrawal .
6148524	0	somatostatin	69,81	growth_hormone	41,55	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	SMS_201-995|compound|START_ENTITY secretion|nmod|SMS_201-995 secretion|nsubj|suppression suppression|nmod|END_ENTITY	Long-acting and selective suppression of growth_hormone secretion by somatostatin analogue SMS_201-995 in acromegaly .
6150052	0	somatostatin	66,78	growth_hormone	31,45	somatostatin	growth hormone	MESH:D013004	443329(Tax:9940)	Chemical	Gene	analogs|compound|START_ENTITY release|nmod|analogs release|nsubj|Suppression Suppression|nmod|END_ENTITY	Suppression and stimulation of growth_hormone release in sheep by somatostatin analogs .
6150770	0	somatostatin	46,58	growth_hormone	84,98	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	decrease|compound|START_ENTITY decrease|acl|associated associated|nmod|increase increase|amod|END_ENTITY	Studies in constitutionally tall adolescents : somatostatin decrease associated with growth_hormone increase after TRH injection .
640235	0	somatostatin	34,46	growth_hormone	71,85	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	effects|nmod|START_ENTITY studies|nmod|effects studies|nmod|levels levels|nmod|END_ENTITY	24-hour studies of the effects of somatostatin on the levels of plasma growth_hormone , glucagon , and glucose in normal subjects and juvenile diabetics .
688665	0	somatostatin	49,61	growth_hormone	12,26	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	content|compound|START_ENTITY administration|nmod|content administration|amod|END_ENTITY	-LSB- Effects of growth_hormone administration on the somatostatin content of the hypothalamus -RSB- .
744057	0	somatostatin	13,25	growth_hormone	68,82	somatostatin	growth hormone	MESH:D013004	81668(Tax:10116)	Chemical	Gene	Antiserum|nmod|START_ENTITY reverses|nsubj|Antiserum reverses|dobj|inhibition inhibition|nmod|END_ENTITY	Antiserum to somatostatin reverses starvation-induced inhibition of growth_hormone but not insulin secretion .
747898	0	somatostatin	33,45	growth_hormone	15,29	somatostatin	growth hormone	MESH:D013004	81668(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY END_ENTITY|nmod|release	Stimulation by growth_hormone of somatostatin release from the rat hypothalamus in vitro .
7485482	0	somatostatin	40,52	growth_hormone	75,89	somatostatin	growth hormone	MESH:D013004	81668(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY evidence|nmod|role pulsatile|nmod|evidence pulsatile|dobj|secretion secretion|amod|END_ENTITY	In vivo evidence of a positive role for somatostatin to optimize pulsatile growth_hormone secretion .
7550296	0	somatostatin	170,182	growth_hormone	26,40	somatostatin	growth hormone	MESH:D013004	81668(Tax:10116)	Chemical	Gene	antiserum|nmod|START_ENTITY deafferentation|nmod|antiserum END_ENTITY|nmod|deafferentation	Caloric intake stimulates growth_hormone secretion in food-deprived rats with anterolateral deafferentation of the medial_basal_hypothalamus or administered antiserum to somatostatin .
7593445	0	somatostatin	169,181	growth_hormone	26,40	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	involvement|nmod|START_ENTITY administration|dep|involvement preserved|nmod|administration preserved|nsubjpass|augmentation augmentation|nmod|secretion secretion|amod|END_ENTITY	Nocturnal augmentation of growth_hormone -LRB- GH -RRB- secretion is preserved during repetitive bolus administration of GH-releasing hormone : potential involvement of endogenous somatostatin -- a clinical research center study .
7621570	0	somatostatin	41,53	growth_hormone	93,107	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	analogue|compound|START_ENTITY infusion|nmod|analogue effect|nmod|infusion effect|nmod|years years|nmod|secretion secretion|amod|END_ENTITY	The effect of a continuous infusion of a somatostatin analogue -LRB- octreotide -RRB- for two years on growth_hormone secretion and height prediction in tall children .
7738479	0	somatostatin	116,128	growth_hormone	68,82	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	action|compound|START_ENTITY inhibited|nmod|action inhibited|nsubj|effects effects|nmod|hexapeptide hexapeptide|nmod|release release|amod|END_ENTITY	Central effects of growth_hormone-releasing hexapeptide -LRB- GHRP-6 -RRB- on growth_hormone release are inhibited by central somatostatin action .
773950	0	somatostatin	11,23	growth_hormone	50,64	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	START_ENTITY|nmod|levels levels|nmod|END_ENTITY	Effects of somatostatin on basal levels of plasma growth_hormone and insulin in acromegalics : dose-response studies and attempted total growth_hormone suppression .
8096234	0	somatostatin	41,53	growth_hormone	70,84	somatostatin	growth hormone	MESH:D013004	443329(Tax:9940)	Chemical	Gene	immunoneutralization|nmod|START_ENTITY affect|nsubj|immunoneutralization affect|dobj|secretion secretion|amod|END_ENTITY	Acute or chronic immunoneutralization of somatostatin does not affect growth_hormone or thyroid hormone secretion in sheep .
8101732	0	somatostatin	83,95	growth_hormone	44,58	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	chemotaxis|nmod|START_ENTITY chemotaxis|nmod|END_ENTITY	Stimulation of monocyte chemotaxis by human growth_hormone and its deactivation by somatostatin .
8222296	0	somatostatin	107,119	growth_hormone	41,55	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	analogue|compound|START_ENTITY growth_hormone|nmod|analogue growth_hormone|nsubj|rate rate|nmod|END_ENTITY	Metabolic clearance rate of biosynthetic growth_hormone after endogenous growth_hormone suppression with a somatostatin analogue in chronic_renal_failure patients and control subjects .
8222296	0	somatostatin	107,119	growth_hormone	73,87	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	analogue|compound|START_ENTITY END_ENTITY|nmod|analogue	Metabolic clearance rate of biosynthetic growth_hormone after endogenous growth_hormone suppression with a somatostatin analogue in chronic_renal_failure patients and control subjects .
8257527	0	somatostatin	18,30	growth_hormone	62,76	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	SMS_201-995|compound|START_ENTITY Pretreatment|nmod|SMS_201-995 potentiates|nsubj|Pretreatment potentiates|dobj|responsiveness responsiveness|amod|END_ENTITY	Pretreatment with somatostatin analog SMS_201-995 potentiates growth_hormone -LRB- GH -RRB- responsiveness to GH-releasing factor in short children .
8405033	0	somatostatin	95,107	growth_hormone	37,51	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	BIM_23014|compound|START_ENTITY study|nmod|BIM_23014 study|nmod|secretion secretion|amod|END_ENTITY	Pharmacokinetic study and effects on growth_hormone secretion in healthy volunteers of the new somatostatin analogue BIM_23014 .
8626871	0	somatostatin	134,146	growth_hormone	16,30	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	tonus|compound|START_ENTITY elevation|nmod|tonus caused|nmod|elevation caused|nsubjpass|decrease decrease|nmod|response response|amod|END_ENTITY	The decrease in growth_hormone -LRB- GH -RRB- response after repeated stimulation with GH-releasing hormone is partly caused by an elevation of somatostatin tonus .
8910805	0	somatostatin	30,42	growth_hormone	76,90	somatostatin	growth hormone	MESH:D013004	81668(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY induces|nsubj|receptors induces|dobj|increase increase|nmod|release release|amod|END_ENTITY	Activation of locus coeruleus somatostatin receptors induces an increase of growth_hormone release in male rats .
9053782	0	somatostatin	65,77	growth_hormone	91,105	somatostatin	growth hormone	MESH:D013004	81668(Tax:10116)	Chemical	Gene	analogue|compound|START_ENTITY octreotide|appos|analogue Effects|nmod|octreotide Effects|nmod|regulation regulation|amod|END_ENTITY	Effects of neonatal administration of octreotide , a long-lasting somatostatin analogue , on growth_hormone regulation in the adult rat .
9380276	0	somatostatin	110,122	growth_hormone	19,33	somatostatin	growth hormone	MESH:D013004	81668(Tax:10116)	Chemical	Gene	action|compound|START_ENTITY arcuate|nmod|action arcuate|nsubj|Attenuation Attenuation|nmod|induction induction|amod|END_ENTITY	Attenuation of the growth_hormone secretagogue induction of Fos protein in the rat arcuate nucleus by central somatostatin action .
9425393	0	somatostatin	67,79	growth_hormone	19,33	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	releasing|nmod|START_ENTITY Interaction|acl|releasing Interaction|nmod|END_ENTITY	Interaction of the growth_hormone releasing peptide hexarelin with somatostatin .
947121	0	somatostatin	76,88	growth_hormone	25,39	somatostatin	growth hormone	MESH:D013004	2688	Chemical	Gene	infusion|nmod|START_ENTITY secretion|nmod|infusion secretion|compound|END_ENTITY	Studies on the postponed growth_hormone secretion following the infusion of somatostatin .
9564833	0	somatostatin	30,42	growth_hormone	89,103	somatostatin	growth hormone	MESH:D013004	81668(Tax:10116)	Chemical	Gene	expression|compound|START_ENTITY effects|nmod|expression Effect|nmod|effects Effect|nmod|release release|compound|END_ENTITY	Effect of 17beta-estradiol on somatostatin receptor expression and inhibitory effects on growth_hormone and prolactin release in rat pituitary cell cultures .
1352390	0	somatostatin	60,72	growth_hormone-releasing_factor	25,56	somatostatin	growth hormone-releasing factor	MESH:D013004	29446(Tax:10116)	Chemical	Gene	regulation|compound|START_ENTITY produced|nmod|regulation produced|dobj|END_ENTITY	Role of locally produced growth_hormone-releasing_factor in somatostatin regulation by fetal rat brain cells in culture .
1675472	0	somatostatin	81,93	growth_hormone-releasing_factor	20,51	somatostatin	growth hormone-releasing factor	MESH:D013004	29446(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|release release|nmod|END_ENTITY	In vitro release of growth_hormone-releasing_factor -LRB- GRF -RRB- from the hypothalamus : somatostatin inhibits GRF release .
1684146	0	somatostatin	39,51	growth_hormone-releasing_factor	80,111	somatostatin	growth hormone-releasing factor	MESH:D013004	2691	Chemical	Gene	immunization|nmod|START_ENTITY Effects|nmod|immunization and/or|nsubj|Effects and/or|dobj|injections injections|nmod|END_ENTITY	Effects of active immunization against somatostatin -LRB- SRIF -RRB- and/or injections of growth_hormone-releasing_factor -LRB- GRF -RRB- during gestation on hormonal and metabolic profiles in sows .
1976042	0	somatostatin	25,37	growth_hormone-releasing_factor	82,113	somatostatin	growth hormone-releasing factor	MESH:D013004	29446(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY activated|nsubj|effects activated|nmod|END_ENTITY	Morphological effects of somatostatin on rat somatotrophs previously activated by growth_hormone-releasing_factor .
2899498	0	somatostatin	55,67	growth_hormone-releasing_factor	71,102	somatostatin	growth hormone-releasing factor	MESH:D013004	29446(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Inhibitory effect of hypothalamic medial preoptic area somatostatin on growth_hormone-releasing_factor in the rat .
7903977	0	somatostatin	22,34	growth_hormone-releasing_factor	47,78	somatostatin	growth hormone-releasing factor	MESH:D013004	29446(Tax:10116)	Chemical	Gene	exposure|nmod|START_ENTITY Timing|nmod|exposure dictates|nsubj|Timing dictates|advmod|relative relative|nmod|END_ENTITY	Timing of exposure to somatostatin relative to growth_hormone-releasing_factor dictates the rat anterior pituitary cell growth hormone response .
1347904	0	somatostatin	138,150	growth_hormone-releasing_hormone	35,67	somatostatin	growth hormone-releasing hormone	MESH:D013004	29446(Tax:10116)	Chemical	Gene	tone|compound|START_ENTITY conditions|nmod|tone secretion|nmod|conditions Effects|nmod|secretion Effects|nmod|END_ENTITY	Effects of passive immunization of growth_hormone-releasing_hormone and somatostatin on growth_hormone secretion under conditions of high somatostatin tone .
1355850	0	somatostatin	104,116	growth_hormone-releasing_hormone	17,49	somatostatin	growth hormone-releasing hormone	MESH:D013004	780526(Tax:9940)	Chemical	Gene	analog|compound|START_ENTITY BIM_23014|appos|analog changes|nmod|BIM_23014 changes|nmod|secretion secretion|amod|END_ENTITY	Acute changes in growth_hormone-releasing_hormone secretion after injection of BIM_23014 , a long acting somatostatin analog , in rams .
19017754	0	somatostatin	11,23	growth_hormone-releasing_hormone	37,69	somatostatin	growth hormone-releasing hormone	MESH:D013004	2691	Chemical	Gene	analogs|compound|START_ENTITY analogs|nmod|secreting secreting|amod|END_ENTITY	Effects of somatostatin analogs on a growth_hormone-releasing_hormone secreting bronchial_carcinoid , in vivo and in vitro studies .
7617135	0	somatostatin	47,59	growth_hormone-releasing_hormone	63,95	somatostatin	growth hormone-releasing hormone	MESH:D013004	14601(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	Discordant effects of endogenous and exogenous somatostatin on growth_hormone-releasing_hormone secretion from perifused mouse hypothalami .
8530634	0	somatostatin	107,119	growth_hormone-releasing_hormone	46,78	somatostatin	growth hormone-releasing hormone	MESH:D013004	2691	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|response response|nmod|END_ENTITY	In obesity the somatotrope response to either growth_hormone-releasing_hormone or arginine is inhibited by somatostatin or pirenzepine but not by glucose .
21055629	0	somatostatin	81,93	hsstr2	114,120	somatostatin	hsstr2	MESH:D013004	6752	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Treatment of transplanted tumor_of_lung_adenocarcinoma A549 transfected by human somatostatin receptor subtype 2 -LRB- hsstr2 -RRB- gene with 188Re-RC-160 .
1108017	0	somatostatin	5,17	insulin	32,39	somatostatin	insulin	MESH:D013004	3630	Chemical	Gene	inhibition|compound|START_ENTITY involve|nsubj|inhibition involve|nmod|secretion secretion|compound|END_ENTITY	Does somatostatin inhibition of insulin secretion involve two mechanisms of action ?
11341594	0	somatostatin	25,37	insulin	62,69	somatostatin	insulin	MESH:D013004	3630	Chemical	Gene	effect|nmod|START_ENTITY immunoneutralization|nsubj|effect immunoneutralization|nmod|secretion secretion|compound|END_ENTITY	The effect of intraislet somatostatin immunoneutralization on insulin secretion in the isolated perfused rat pancreas .
12952367	0	somatostatin	89,101	insulin	14,21	somatostatin	insulin	MESH:D013004	3630	Chemical	Gene	analogues|compound|START_ENTITY Evaluation|nmod|analogues Evaluation|nmod|resistance resistance|compound|END_ENTITY	Evaluation of insulin resistance in acromegalic patients before and after treatment with somatostatin analogues .
14576502	0	somatostatin	14,26	insulin	55,62	somatostatin	insulin	MESH:D013004	3630	Chemical	Gene	receptor|compound|START_ENTITY Activation|nmod|receptor subtype|nsubj|Activation subtype|dobj|secretion secretion|compound|END_ENTITY	Activation of somatostatin receptor subtype 2 inhibits insulin secretion in the isolated perfused human pancreas .
1680775	0	somatostatin	15,27	insulin	51,58	somatostatin	insulin	MESH:D013004	3630	Chemical	Gene	effect|nmod|START_ENTITY -LSB-|dobj|effect -LSB-|nmod|specific specific|nmod|END_ENTITY	-LSB- The effect of somatostatin on specific binding of insulin to receptors in patients with non-insulin_dependent_diabetes -RSB- .
1967577	0	somatostatin	67,79	insulin	96,103	somatostatin	insulin	MESH:D013004	483665(Tax:9615)	Chemical	Gene	normalization|nmod|START_ENTITY glucagon|nmod|normalization reduction|nmod|glucagon reduction|nmod|END_ENTITY	Paradoxical reduction in pancreatic glucagon with normalization of somatostatin and decrease in insulin in normoglycemic alloxan-diabetic dogs : a putative mechanism of glucagon irresponsiveness to hypoglycemia .
1980258	0	somatostatin	10,22	insulin	37,44	somatostatin	insulin	MESH:D013004	3630	Chemical	Gene	raises|nsubj|START_ENTITY raises|dobj|levels levels|compound|END_ENTITY	Exogenous somatostatin raises plasma insulin levels in patients with insulin-dependent_diabetes_mellitus .
1980734	0	somatostatin	14,26	insulin	30,37	somatostatin	insulin	MESH:D013004	483665(Tax:9615)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|levels levels|compound|END_ENTITY	The effect of somatostatin on insulin and glucose levels during insulin infusion in anesthetized dogs .
1980734	0	somatostatin	14,26	insulin	64,71	somatostatin	insulin	MESH:D013004	483665(Tax:9615)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|infusion infusion|compound|END_ENTITY	The effect of somatostatin on insulin and glucose levels during insulin infusion in anesthetized dogs .
210358	0	somatostatin	11,23	insulin	27,34	somatostatin	insulin	MESH:D013004	3630	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|biosynthesis biosynthesis|compound|END_ENTITY	Effects of somatostatin on insulin biosynthesis , glucose oxidation , and cyclic guanosine monophosphate level .
231062	0	somatostatin	11,23	insulin	27,34	somatostatin	insulin	MESH:D013004	3630	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of somatostatin on insulin and glucagon in patients with insulinoma .
2657326	3	somatostatin	1297,1309	insulin	1339,1346	somatostatin	insulin	MESH:D013004	3630	Chemical	Gene	used|nsubjpass|START_ENTITY used|xcomp|block block|dobj|response response|compound|END_ENTITY	In all protocols , somatostatin was used to block endogenous insulin response .
2687064	0	somatostatin	31,43	insulin	140,147	somatostatin	insulin	MESH:D013004	3630	Chemical	Gene	analogue|nmod|START_ENTITY Sandostatin|appos|analogue reduces|nsubj|Sandostatin reduces|dep|induced induced|nmod|interruption interruption|nmod|infusion infusion|compound|END_ENTITY	Sandostatin , a new analogue of somatostatin , reduces the metabolic changes induced by the nocturnal interruption of continuous subcutaneous insulin infusion in type 1 -LRB- insulin-dependent -RRB- diabetic patients .
2885161	0	somatostatin	22,34	insulin	108,115	somatostatin	insulin	MESH:D013004	3630	Chemical	Gene	response|compound|START_ENTITY immunoreactive|dobj|response immunoreactive|xcomp|arginine arginine|nmod|infusion infusion|compound|END_ENTITY	Plasma immunoreactive somatostatin response to arginine after glycemic control with continuous subcutaneous insulin infusion in type I diabetics .
4127645	0	somatostatin	35,47	insulin	14,21	somatostatin	insulin	MESH:D013004	3630	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of insulin secretion by somatostatin .
6114891	0	somatostatin	11,23	insulin	33,40	somatostatin	insulin	MESH:D013004	3630	Chemical	Gene	Effects|nmod|START_ENTITY added|nsubj|Effects added|nmod|END_ENTITY	Effects of somatostatin added to insulin in a glucose-controlled insulin infusion system .
6114891	0	somatostatin	11,23	insulin	65,72	somatostatin	insulin	MESH:D013004	3630	Chemical	Gene	Effects|nmod|START_ENTITY added|nsubj|Effects added|nmod|system system|compound|END_ENTITY	Effects of somatostatin added to insulin in a glucose-controlled insulin infusion system .
6117492	0	somatostatin	99,111	insulin	14,21	somatostatin	insulin	MESH:D013004	3630	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Evaluation Evaluation|nmod|resistance resistance|compound|END_ENTITY	Evaluation of insulin resistance during inhibition of endogenous insulin and glucagon secretion by somatostatin in non-obese subjects with impaired_glucose_tolerance .
6117492	0	somatostatin	99,111	insulin	65,72	somatostatin	insulin	MESH:D013004	3630	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Evaluation Evaluation|nmod|resistance resistance|nmod|inhibition inhibition|nmod|END_ENTITY	Evaluation of insulin resistance during inhibition of endogenous insulin and glucagon secretion by somatostatin in non-obese subjects with impaired_glucose_tolerance .
6136354	0	somatostatin	103,115	insulin	25,32	somatostatin	insulin	MESH:D013004	3630	Chemical	Gene	-RSB-|compound|START_ENTITY pancreas|nmod|-RSB- secretion|nmod|pancreas secretion|nsubj|mechanism mechanism|nmod|END_ENTITY	-LSB- Regulation mechanism of insulin and glucagon secretion from the isolated , perfused canine pancreas by somatostatin -RSB- .
6139329	0	somatostatin	23,35	insulin	64,71	somatostatin	insulin	MESH:D013004	3630	Chemical	Gene	effects|nmod|START_ENTITY analogs|nsubj|effects analogs|nmod|release release|compound|END_ENTITY	Dissociated effects of somatostatin analogs on arginine-induced insulin , glucagon and growth hormone release in acromegalic patients .
6150771	0	somatostatin	29,41	insulin	56,63	somatostatin	insulin	MESH:D013004	3630	Chemical	Gene	mechanisms|nmod|START_ENTITY Studies|nmod|mechanisms release|nsubj|Studies release|nmod|END_ENTITY	Studies on the mechanisms of somatostatin release after insulin induced hypoglycaemia in man .
7349954	0	somatostatin	14,26	insulin	56,63	somatostatin	insulin	MESH:D013004	483665(Tax:9615)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|extraction extraction|nmod|END_ENTITY	The effect of somatostatin on the hepatic extraction of insulin and glucagon in the anesthetized dog .
747892	0	somatostatin	49,61	insulin	92,99	somatostatin	insulin	MESH:D013004	3630	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|release release|compound|END_ENTITY	The effect of serum ionized calcium elevation on somatostatin inhibition of glucose-induced insulin release in humans .
7847192	0	somatostatin	27,39	insulin	101,108	somatostatin	insulin	MESH:D013004	105613195	Chemical	Gene	analogue|compound|START_ENTITY Effects|nmod|analogue octreotide|nsubj|Effects octreotide|nmod|function function|nmod|END_ENTITY	Effects of the long-acting somatostatin analogue octreotide on abomasal function and plasma level of insulin and glucagon in sheep .
7849444	0	somatostatin	18,30	insulin	72,79	somatostatin	insulin	MESH:D013004	3630	Chemical	Gene	analogue|compound|START_ENTITY Effect|nmod|analogue SMS|nsubj|Effect SMS|nmod|END_ENTITY	Effect of the new somatostatin analogue SMS 201-995 on exogenously used insulin .
7910686	0	somatostatin	30,42	insulin	46,53	somatostatin	insulin	MESH:D013004	3630	Chemical	Gene	role|nmod|START_ENTITY role|nmod|secretion secretion|compound|END_ENTITY	Regulatory role of intraislet somatostatin on insulin secretion in the isolated perfused human pancreas .
8507446	0	somatostatin	14,26	insulin	43,50	somatostatin	insulin	MESH:D013004	3630	Chemical	Gene	analog|compound|START_ENTITY Octreotide|appos|analog reduces|nsubj|Octreotide reduces|dobj|secretion secretion|compound|END_ENTITY	Octreotide , a somatostatin analog , reduces insulin secretion and increases renal Na + excretion in lean essential hypertensive patients .
946565	0	somatostatin	28,40	insulin	51,58	somatostatin	insulin	MESH:D013004	3630	Chemical	Gene	action|compound|START_ENTITY mechanism|nmod|action Studies|nmod|mechanism Studies|nmod|release release|compound|END_ENTITY	Studies on the mechanism of somatostatin action on insulin release .
946565	2	somatostatin	83,95	insulin	127,134	somatostatin	insulin	MESH:D013004	3630	Chemical	Gene	Effect|nmod|START_ENTITY induced|nsubj|Effect induced|dobj|release release|nmod|END_ENTITY	Effect of somatostatin on arginine induced release of insulin and glucagon in man and perfused rat pancreas .
12187277	0	somatostatin	73,85	insulin-like_growth_factor-I	14,42	somatostatin	insulin-like growth factor-I	MESH:D013004	24482(Tax:10116)	Chemical	Gene	analogue|compound|START_ENTITY using|dobj|analogue Modulation|acl|using Modulation|nmod|system system|compound|END_ENTITY	Modulation of insulin-like_growth_factor-I system of the bladder using a somatostatin analogue in chronic spinalized rats .
9121116	0	somatostatin	18,30	insulin-like_growth_factor-I	52,80	somatostatin	insulin-like growth factor-I	MESH:D013004	24482(Tax:10116)	Chemical	Gene	analog|compound|START_ENTITY effects|nmod|analog octreotide|nsubj|effects octreotide|nmod|END_ENTITY	Direct effects of somatostatin analog octreotide on insulin-like_growth_factor-I in the arterial wall .
9159422	0	somatostatin	2,14	insulin-like_growth_factor-I	97,125	somatostatin	insulin-like growth factor-I	MESH:D013004	24482(Tax:10116)	Chemical	Gene	analogue|compound|START_ENTITY decreases|nsubj|analogue decreases|advcl|normalizing normalizing|dobj|action action|amod|END_ENTITY	A somatostatin analogue decreases embryonic_loss following superovulation in rats by normalizing insulin-like_growth_factor-I action in the uterus .
7908609	0	somatostatin	101,113	insulin-like_growth_factor_I	16,44	somatostatin	insulin-like growth factor I	MESH:D013004	3479	Chemical	Gene	analogues|compound|START_ENTITY Localization|nmod|analogues Localization|nmod|END_ENTITY	Localization of insulin-like_growth_factor_I and inhibition of coronary smooth muscle cell growth by somatostatin analogues in human coronary smooth muscle cells .
10029602	0	somatostatin	4,16	interleukin-6	54,67	somatostatin	interleukin-6	MESH:D013004	3569	Chemical	Gene	octreotide|compound|START_ENTITY inhibits|nsubj|octreotide inhibits|dobj|growth growth|nmod|lines lines|amod|END_ENTITY	The somatostatin analog octreotide inhibits growth of interleukin-6 -LRB- IL-6 -RRB- - dependent and IL-6-independent human multiple_myeloma cell lines .
12060857	0	somatostatin	22,34	interleukin-6	74,87	somatostatin	interleukin-6	MESH:D013004	3569	Chemical	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	Inhibitory effects of somatostatin on tumor_necrosis_factor-alpha-induced interleukin-6 secretion in human pancreatic periacinar myofibroblasts .
8654950	0	somatostatin	59,71	mSSTR4	103,109	somatostatin	mSSTR4	MESH:D013004	20608(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|gene gene|appos|END_ENTITY	Isolation and characterization of the mouse -LRB- Mus_musculus -RRB- somatostatin receptor type-4-encoding gene -LRB- mSSTR4 -RRB- .
9404722	0	somatostatin	186,198	neuropeptide_Y	152,166	somatostatin	neuropeptide Y	MESH:D013004	24604(Tax:10116)	Chemical	Gene	enhancement|nmod|START_ENTITY enhancement|nmod|END_ENTITY	Opposite effects of astrocyte-derived soluble factor -LRB- s -RRB- on the functional expression of fetal peptidergic neurons in aggregate cultures : enhancement of neuropeptide_Y and suppression of somatostatin .
2859907	0	somatostatin	106,118	neurotensin	15,26	somatostatin	neurotensin	MESH:D013004	4922	Chemical	Gene	secretion|nmod|START_ENTITY vasoactive|nmod|secretion vasoactive|nsubj|effects effects|nmod|END_ENTITY	The effects of neurotensin , vasoactive intestinal polypeptide and other neuropeptides on the secretion of somatostatin from cerebral cortical cells .
2867526	0	somatostatin	68,80	neurotensin	14,25	somatostatin	neurotensin	MESH:D013004	299757(Tax:10116)	Chemical	Gene	analog|nmod|START_ENTITY release|nmod|analog release|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of neurotensin release by a cyclic_hexapeptide analog of somatostatin .
6163624	0	somatostatin	114,126	neurotensin	40,51	somatostatin	neurotensin	MESH:D013004	299757(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY immunoreactive|dobj|levels immunoreactive|nsubj|Effect Effect|nmod|injection injection|nmod|END_ENTITY	Effect of intraventricular injection of neurotensin and other various bioactive peptides on plasma immunoreactive somatostatin levels in rat hypophysial portal blood .
7652191	0	somatostatin	13,25	neurotensin	29,40	somatostatin	neurotensin	MESH:D013004	4922	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|compound|END_ENTITY	An effect of somatostatin on neurotensin secretion .
11435757	0	somatostatin	85,97	neurotrophin-3	67,81	somatostatin	neurotrophin-3	MESH:D013004	4908	Chemical	Gene	release|compound|START_ENTITY END_ENTITY|nmod|release	Rapid stimulatory effects of brain-derived_neurotrophic_factor and neurotrophin-3 on somatostatin release and intracellular calcium rise in primary hypothalamic cell cultures .
12137964	0	somatostatin	35,47	nociceptin	21,31	somatostatin	nociceptin	MESH:D013004	25516(Tax:10116)	Chemical	Gene	secretion|compound|START_ENTITY effect|nmod|secretion effect|nmod|END_ENTITY	Inhibitory effect of nociceptin on somatostatin secretion of the isolated perfused rat stomach .
2569658	0	somatostatin	44,56	oxytocin	75,83	somatostatin	oxytocin	MESH:D013004	5020	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|release release|nmod|END_ENTITY	Naloxone abolishes the inhibiting effect of somatostatin on the release of oxytocin evoked by insulin-induced hypoglycemia in humans .
16917505	0	somatostatin	30,42	p85	18,21	somatostatin	p85	MESH:D013004	5296	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	Direct binding of p85 to sst2 somatostatin receptor reveals a novel mechanism for inhibiting PI3K pathway .
2465985	0	somatostatin	188,200	pancreatic_polypeptide	220,242	somatostatin	pancreatic polypeptide	MESH:D013004	5539	Chemical	Gene	neurotensin|dep|START_ENTITY neurotensin|dep|END_ENTITY	Chronic_pancreatitis and diabetes_mellitus : plasma and gastroduodenal_mucosal profiles of regulatory peptides -LRB- gastrin , motilin , secretin , cholecystokinin , gastric inhibitory polypeptide , somatostatin , VIP , substance_P , pancreatic_polypeptide , glucagon , enteroglucagon , neurotensin -RRB- .
481222	0	somatostatin	19,31	parathyroid_hormone	52,71	somatostatin	parathyroid hormone	MESH:D013004	24694(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|nmod|END_ENTITY	Role of endogenous somatostatin in the secretion of parathyroid_hormone and calcitonin .
1358652	0	somatostatin	38,50	prolactin	65,74	somatostatin	prolactin	MESH:D013004	5617	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|secretion secretion|compound|END_ENTITY	Antidiabetic sulfonylureas antagonize somatostatin inhibition of prolactin secretion in vitro .
2461851	0	somatostatin	181,193	prolactin	62,71	somatostatin	prolactin	MESH:D013004	24683(Tax:10116)	Chemical	Gene	interactions|nmod|START_ENTITY activity|dep|interactions activity|acl|related related|xcomp|END_ENTITY	Dihydropyridine-sensitive calcium channel activity related to prolactin , growth_hormone , and luteinizing hormone release from anterior pituitary cells in culture : interactions with somatostatin , dopamine , and estrogens .
2869031	0	somatostatin	49,61	prolactin	172,181	somatostatin	prolactin	MESH:D013004	24683(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY blocks|dobj|effects blocks|nmod|secretion secretion|compound|END_ENTITY	Pertussis toxin blocks the inhibitory effects of somatostatin on cAMP-dependent_vasoactive_intestinal_peptide and cAMP-independent thyrotropin_releasing_hormone-stimulated prolactin secretion of GH3 cells .
2887502	0	somatostatin	33,45	prolactin	49,58	somatostatin	prolactin	MESH:D013004	5617	Chemical	Gene	Absence|nmod|START_ENTITY Absence|nmod|levels levels|compound|END_ENTITY	Absence of suppressive effect of somatostatin on prolactin levels in patients with hyperprolactinemia .
45279	0	somatostatin	12,24	prolactin	30,39	somatostatin	prolactin	MESH:D013004	5617	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|compound|END_ENTITY	-LSB- Effects of somatostatin upon prolactin secretion both in normal subjects and in patients presenting pituitary_adenoma -LRB- author 's transl -RRB- -RSB- .
1352707	0	somatostatin	25,37	renin	89,94	somatostatin	renin	MESH:D013004	24715(Tax:10116)	Chemical	Gene	exerts|nsubj|START_ENTITY exerts|dobj|effect effect|nmod|END_ENTITY	Evidence that endogenous somatostatin -LRB- SRIF -RRB- exerts a tonic inhibitory effect on the rat renin -- angiotensin -- aldosterone system .
477626	0	somatostatin	10,22	renin	33,38	somatostatin	renin	MESH:D013004	403838(Tax:9615)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|compound|END_ENTITY	Effect of somatostatin on plasma renin activity .
56589	3	somatostatin	524,536	renin	538,543	somatostatin	renin	MESH:D013004	5972	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|release release|compound|END_ENTITY	Injection of frusemide alone produced hyperreninaemia ; but , under somatostatin , renin release was inhibited by 45 % .
6109626	0	somatostatin	10,22	renin	33,38	somatostatin	renin	MESH:D013004	5972	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|compound|END_ENTITY	Effect of somatostatin on plasma renin activity and blood pressure in patients with essential hypertension .
935618	0	somatostatin	11,23	renin	27,32	somatostatin	renin	MESH:D013004	24715(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	-LSB- Effect of somatostatin on renin secretion in the isolated perfused rat kidney -LRB- author 's transl -RRB- -RSB- .
11405660	0	somatostatin	7,19	somatostatin_receptor_1	57,80	somatostatin	somatostatin receptor 1	MESH:D013004	6751	Chemical	Gene	undecapeptide|compound|START_ENTITY agonists|nsubj|undecapeptide agonists|xcomp|selective selective|nmod|END_ENTITY	Potent somatostatin undecapeptide agonists selective for somatostatin_receptor_1 -LRB- sst1 -RRB- .
22158494	0	somatostatin	55,67	somatostatin_receptor_subtypes_2_and_5	13,51	somatostatin	somatostatin receptor subtypes 2 and 5	MESH:D013004	6755	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	Detection of somatostatin_receptor_subtypes_2_and_5 by somatostatin receptor scintigraphy and immunohistochemistry : clinical implications in the diagnostic and therapeutic management of gastroenteropancreatic_neuroendocrine_tumors .
11405660	0	somatostatin	7,19	sst1	82,86	somatostatin	sst1	MESH:D013004	6751	Chemical	Gene	undecapeptide|compound|START_ENTITY agonists|nsubj|undecapeptide agonists|xcomp|selective selective|nmod|somatostatin_receptor_1 somatostatin_receptor_1|appos|END_ENTITY	Potent somatostatin undecapeptide agonists selective for somatostatin_receptor_1 -LRB- sst1 -RRB- .
16274747	0	somatostatin	4,16	sst1	17,21	somatostatin	sst1	MESH:D013004	112256(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	The somatostatin sst1 receptor : an autoreceptor for somatostatin in brain and retina ?
16274747	0	somatostatin	52,64	sst1	17,21	somatostatin	sst1	MESH:D013004	112256(Tax:10090)	Chemical	Gene	autoreceptor|nmod|START_ENTITY receptor|dep|autoreceptor receptor|amod|END_ENTITY	The somatostatin sst1 receptor : an autoreceptor for somatostatin in brain and retina ?
23466804	0	somatostatin	21,33	sst1	16,20	somatostatin	sst1	MESH:D013004	6751	Chemical	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Reevaluation of sst1 somatostatin receptor expression in human normal and neoplastic tissues using the novel rabbit monoclonal antibody UMB-7 .
10197759	0	somatostatin	99,111	sst2	94,98	somatostatin	sst2	MESH:D013004	20606(Tax:10090)	Chemical	Gene	subtype|compound|START_ENTITY subtype|amod|END_ENTITY	Cortistatin affects glutamate sensitivity in mouse hypothalamic neurons through activation of sst2 somatostatin receptor subtype .
10223733	0	somatostatin	81,93	sst2	103,107	somatostatin	sst2	MESH:D013004	20606(Tax:10090)	Chemical	Gene	transfer|amod|START_ENTITY transfer|amod|END_ENTITY	Gene therapy for pancreatic_carcinoma : local and distant antitumor effects after somatostatin receptor sst2 gene transfer .
10329727	0	somatostatin	5,17	sst2	0,4	somatostatin	sst2	MESH:D013004	20606(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	sst2 somatostatin receptor mediates cell cycle arrest and induction of p27 -LRB- Kip1 -RRB- .
11029646	0	somatostatin	20,32	sst2	15,19	somatostatin	SRIF	MESH:D013004	20604(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Involvement of sst2 somatostatin receptor in locomotor , exploratory activity and emotional reactivity in mice .
11278805	0	somatostatin	41,53	sst2	36,40	somatostatin	sst2	MESH:D013004	20606(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|activation activation|nmod|END_ENTITY	Transcriptional activation of mouse sst2 somatostatin receptor promoter by transforming growth factor-beta .
15655503	0	somatostatin	62,74	sst2	25,29	somatostatin	sst2	MESH:D013004	54305(Tax:10116)	Chemical	Gene	endogenous|acl|START_ENTITY effects|nmod|endogenous Somatostatin-receptor_2|dep|effects Somatostatin-receptor_2|appos|END_ENTITY	Somatostatin-receptor_2 -LRB- sst2 -RRB- - mediated effects of endogenous somatostatin on exocrine and endocrine secretion of the rat stomach .
16218779	0	somatostatin	44,56	sst2	66,70	somatostatin	sst2	MESH:D013004	20606(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY effect|nmod|receptor Characterization|nmod|effect END_ENTITY|nsubj|Characterization	Characterization of the bystander effect of somatostatin receptor sst2 after in vivo gene transfer into human pancreatic_cancer cells .
17363388	0	somatostatin	100,112	sst2	84,88	somatostatin	sst2	MESH:D013004	20606(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY subtype|nmod|receptor subtype|amod|END_ENTITY	Spontaneous hypersensitivity in mesenteric afferent nerves of mice deficient in the sst2 subtype of somatostatin receptor .
18697876	0	somatostatin	21,33	sst2	16,20	somatostatin	sst2	MESH:D013004	6752	Chemical	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Reassessment of sst2 somatostatin receptor expression in human normal and neoplastic tissues using the novel rabbit monoclonal antibody UMB-1 .
24565897	0	somatostatin	109,121	sst2	104,108	somatostatin	sst2	MESH:D013004	6752	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Carboxyl-terminal multi-site phosphorylation regulates internalization and desensitization of the human sst2 somatostatin receptor .
8621771	0	somatostatin	61,73	sst2	56,60	somatostatin	sst2	MESH:D013004	20606(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Induction of a negative autocrine loop by expression of sst2 somatostatin receptor in NIH 3T3 cells .
14748557	0	somatostatin	49,61	sst3	44,48	somatostatin	sst3	MESH:D013004	25992	Chemical	Gene	proteins|compound|START_ENTITY proteins|amod|END_ENTITY	Differential expression of sst1 , sst2A , and sst3 somatostatin receptor proteins in low-grade and high-grade astrocytomas .
15659149	0	somatostatin	5,17	sst3	18,22	somatostatin	sst3	MESH:D013004	25992	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Fish somatostatin sst3 receptor : comparison of radioligand and GTPgammaS binding , adenylate cyclase and phospholipase C activities reveals different agonist-dependent pharmacological signatures .
2465985	0	somatostatin	188,200	substance_P	207,218	somatostatin	substance P	MESH:D013004	6863	Chemical	Gene	neurotensin|dep|START_ENTITY neurotensin|dep|END_ENTITY	Chronic_pancreatitis and diabetes_mellitus : plasma and gastroduodenal_mucosal profiles of regulatory peptides -LRB- gastrin , motilin , secretin , cholecystokinin , gastric inhibitory polypeptide , somatostatin , VIP , substance_P , pancreatic_polypeptide , glucagon , enteroglucagon , neurotensin -RRB- .
2862016	0	somatostatin	13,25	thyrotropin-releasing_hormone	105,134	somatostatin	thyrotropin-releasing hormone	MESH:D013004	25569(Tax:10116)	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Hypothalamic somatostatin mediates the suppression of growth_hormone secretion by centrally administered thyrotropin-releasing_hormone in conscious rats .
409475	0	somatostatin	10,22	thyrotropin_releasing_hormone	90,119	somatostatin	thyrotropin releasing hormone	MESH:D013004	7200	Chemical	Gene	Effect|nmod|START_ENTITY Effect|acl|END_ENTITY	Effect of somatostatin on thyrotropin , prolactin , growth_hormone and insulin responses to thyrotropin_releasing_hormone and arginine in healthy , hypothyroid and acromegalic subjects .
8978352	0	somatostatin	64,76	transforming_growth_factor_alpha	10,42	somatostatin	transforming growth factor alpha	MESH:D013004	7124	Chemical	Gene	release|compound|START_ENTITY Effect|nmod|release Effect|nmod|END_ENTITY	Effect of transforming_growth_factor_alpha and interleukin_8 on somatostatin release from canine fundic D cells .
3188256	0	somatotropin	15,27	adenosine_deaminase	31,50	somatotropin	adenosine deaminase	MESH:D013006	24165(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY -LSB-|dobj|effect -LSB-|nmod|activity activity|amod|END_ENTITY	-LSB- The effect of somatotropin on adenosine_deaminase activity in tissues of rats with hypo - and hyperthyroidism -RSB- .
8056665	0	somatotropin	10,22	myosin	26,32	somatotropin	myosin	MESH:D013006	396902(Tax:9823)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of somatotropin on myosin expression in pigs .
18357730	0	sophocarpine	11,23	HERG	27,31	sophocarpine	HERG	MESH:C035933	3757	Chemical	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	-LSB- Effect of sophocarpine on HERG K + channels -RSB- .
21232529	0	sophocarpine	26,38	acid-sensing_ion_channel_1	108,134	sophocarpine	acid-sensing ion channel 1	MESH:C035933	79123(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Neuroprotective effect of sophocarpine against transient focal cerebral_ischemia via down-regulation of the acid-sensing_ion_channel_1 in rats .
22521762	0	sophoridine	56,67	TRAF6	103,108	sophoridine	TRAF6	MESH:C034244	311245(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|END_ENTITY	Neuroprotective effect of early and short-time applying sophoridine in pMCAO rat brain : down-regulated TRAF6 and up-regulated p-ERK1 / 2 expression , ameliorated brain infaction and edema .
20650775	0	sophoridine	12,23	p53	57,60	sophoridine	p53	MESH:C034244	22060(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of sophoridine on the growth and expressions of p53 and vascular_endothelial_growth_factor of transplanted solid tumor SW480 in nude_mice -RSB- .
22414764	0	sorafenib	69,78	Epidermal_growth_factor_receptor	0,32	sorafenib	Epidermal growth factor receptor	MESH:C471405	1956	Chemical	Gene	restrict|xcomp|START_ENTITY restrict|nsubj|END_ENTITY	Epidermal_growth_factor_receptor and HER-3 restrict cell response to sorafenib in hepatocellular_carcinoma cells .
18230792	0	sorafenib	32,41	FLT3	7,11	sorafenib	FLT3	MESH:C471405	14255(Tax:10090)	Chemical	Gene	target|nmod|START_ENTITY END_ENTITY|dep|target	Mutant FLT3 : a direct target of sorafenib in acute_myelogenous_leukemia .
24486412	0	sorafenib	34,43	HIF-2a	16,22	sorafenib	HIF-2a	MESH:C471405	2034	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Upregulation of HIF-2a induced by sorafenib contributes to the resistance by activating the TGF-a/EGFR pathway in hepatocellular_carcinoma cells .
25057499	0	sorafenib	40,49	Huh7	64,68	sorafenib	Huh7	MESH:C471405	284424	Chemical	Gene	resistance|amod|START_ENTITY resistance|nmod|cells cells|amod|END_ENTITY	Hepatic stellate cell coculture enables sorafenib resistance in Huh7 cells through HGF/c-Met/Akt and Jak2/Stat3 pathways .
17698840	0	sorafenib	112,121	Mcl-1	0,5	sorafenib	Mcl-1	MESH:C471405	4170	Chemical	Gene	basis|nmod|START_ENTITY members|dep|basis members|amod|END_ENTITY	Mcl-1 as a buffer for proapoptotic Bcl-2 family members during TRAIL-induced apoptosis : a mechanistic basis for sorafenib -LRB- Bay 43-9006 -RRB- - induced TRAIL sensitization .
17909059	0	sorafenib	26,35	Mcl-1	108,113	sorafenib	Mcl-1	MESH:C471405	4170	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|nmod|cells cells|nmod|association association|nmod|down-regulation down-regulation|amod|END_ENTITY	The multikinase inhibitor sorafenib potentiates TRAIL lethality in human leukemia cells in association with Mcl-1 and cFLIPL down-regulation .
19303700	0	sorafenib	87,96	NF-kappaB	0,9	sorafenib	NF-kappaB	MESH:C471405	4790	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	NF-kappaB inhibition in human hepatocellular_carcinoma and its potential as adjunct to sorafenib based therapy .
22294526	0	sorafenib	21,30	PDGFRA	96,102	sorafenib	PDGFRA	MESH:C471405	5156	Chemical	Gene	mutation|amod|START_ENTITY mutation|compound|END_ENTITY	Clinical activity of sorafenib in patients with advanced gastrointestinal_stromal_tumor bearing PDGFRA exon 18 mutation : a case series .
23193917	0	sorafenib	73,82	PTEN	0,4	sorafenib	PTEN	MESH:C471405	5728	Chemical	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	PTEN enhances the sensitivity of human hepatocellular_carcinoma cells to sorafenib .
23812399	0	sorafenib	50,59	RAF1	73,77	sorafenib	RAF1	MESH:C471405	5894	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Novel quinolinylaminoisoquinoline bioisosteres of sorafenib as selective RAF1 kinase inhibitors : design , synthesis , and antiproliferative activity against melanoma cell line .
21751200	0	sorafenib	70,79	S0505	60,65	sorafenib	S0505	MESH:C471405	1080988(Tax:198215)	Chemical	Gene	trial|nmod|START_ENTITY trial|appos|END_ENTITY	Phase 2 Southwest Oncology Group-directed intergroup trial -LRB- S0505 -RRB- of sorafenib in advanced_soft_tissue_sarcomas .
24423918	0	sorafenib	31,40	S0941	0,5	sorafenib	S0941	MESH:C471405	1077343(Tax:198215)	Chemical	Gene	study|nmod|START_ENTITY END_ENTITY|dep|study	S0941 : a phase 2 SWOG study of sorafenib and erlotinib in patients with advanced gallbladder_carcinoma or cholangiocarcinoma .
21354226	0	sorafenib	91,100	Signal_transducer_and_activator_of_transcription_3	0,50	sorafenib	Signal transducer and activator of transcription 3	MESH:C471405	6774	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Signal_transducer_and_activator_of_transcription_3 is a major kinase-independent target of sorafenib in hepatocellular_carcinoma .
17698840	0	sorafenib	112,121	TRAIL	144,149	sorafenib	TRAIL	MESH:C471405	8743	Chemical	Gene	basis|nmod|START_ENTITY members|dep|basis members|dep|END_ENTITY	Mcl-1 as a buffer for proapoptotic Bcl-2 family members during TRAIL-induced apoptosis : a mechanistic basis for sorafenib -LRB- Bay 43-9006 -RRB- - induced TRAIL sensitization .
17909059	0	sorafenib	26,35	TRAIL	48,53	sorafenib	TRAIL	MESH:C471405	8743	Chemical	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|lethality lethality|amod|END_ENTITY	The multikinase inhibitor sorafenib potentiates TRAIL lethality in human leukemia cells in association with Mcl-1 and cFLIPL down-regulation .
19672597	0	sorafenib	69,78	UGT1A1	0,6	sorafenib	UGT1A1	MESH:C471405	54658	Chemical	Gene	received|xcomp|START_ENTITY patient|acl:relcl|received polymorphism|nmod|patient polymorphism|compound|END_ENTITY	UGT1A1 polymorphism and hyperbilirubinemia in a patient who received sorafenib .
23812905	0	sorafenib	57,66	VEGF	29,33	sorafenib	VEGF	MESH:C471405	7422	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	A phase II study of combined VEGF inhibitor -LRB- bevacizumab + sorafenib -RRB- in patients with metastatic breast_cancer : Hoosier Oncology Group Study BRE06-109 .
24510746	0	sorafenib	91,100	VEGF	0,4	sorafenib	VEGF	MESH:C471405	7422	Chemical	Gene	receiving|dobj|START_ENTITY genotyping|advcl|receiving genotyping|nsubj|END_ENTITY	VEGF and VEGFR genotyping in the prediction of clinical outcome for HCC patients receiving sorafenib : the ALICE-1 study .
24375110	0	sorafenib	96,105	VEGFR	0,5	sorafenib	VEGFR	MESH:C471405	3791	Chemical	Gene	treatment|amod|START_ENTITY take|nmod|treatment take|nsubj|END_ENTITY	VEGFR , RET , and RAF/MEK/ERK pathway take part in the inhibition of osteosarcoma MG63 cells with sorafenib treatment .
20810384	0	sorafenib	34,43	epidermal_growth_factor_receptor	64,96	sorafenib	epidermal growth factor receptor	MESH:C471405	1956	Chemical	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	Synergistic antitumor activity of sorafenib in combination with epidermal_growth_factor_receptor inhibitors in colorectal_and_lung_cancer cells .
19336449	0	sorafenib	68,77	interleukin-2	40,53	sorafenib	interleukin-2	MESH:C471405	3558	Chemical	Gene	combined|nmod|START_ENTITY combined|nsubj|efficacy efficacy|nmod|END_ENTITY	Antitumor efficacy of recombinant human interleukin-2 combined with sorafenib against mouse renal_cell_carcinoma .
21932373	0	sorafenib	23,32	mammalian_target_of_rapamycin	53,82	sorafenib	mammalian target of rapamycin	MESH:C471405	2475	Chemical	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	Efficacy and safety of sorafenib in combination with mammalian_target_of_rapamycin inhibitors for recurrent hepatocellular_carcinoma after liver transplantation .
19554262	0	sorafenib	106,115	mcl-1	62,67	sorafenib	mcl-1	MESH:C471405	4170	Chemical	Gene	overcome|nmod|START_ENTITY stabilization|acl:relcl|overcome stabilization|amod|END_ENTITY	Nelfinavir induces mitochondria protection by ERK1/2-mediated mcl-1 stabilization that can be overcome by sorafenib .
19777160	0	sorafenib	24,33	p53	169,172	sorafenib	p53	MESH:C471405	7157	Chemical	Gene	efficacy|nmod|START_ENTITY efficacy|nmod|END_ENTITY	Synergistic efficacy of sorafenib and genistein in growth inhibition by down regulating angiogenic and survival factors and increasing apoptosis through upregulation of p53 and p21 in malignant_neuroblastoma cells having N-Myc amplification or non-amplification .
6788038	0	sorbitol	116,124	Sdh	140,143	sorbitol	Sdh	MESH:D013012	6390	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	Geographical patterns of genetic variability in introduced Australian populations of the marine toad , Bufo marinus : sorbitol dehydrogenase , Sdh .
9268363	0	sorcin	29,35	synexin	64,71	sorcin	synexin	null	310	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Calcium-dependent binding of sorcin to the N-terminal domain of synexin -LRB- annexin_VII -RRB- .
9164418	0	sorivudine	14,24	dihydropyrimidine_dehydrogenase	28,59	sorivudine	dihydropyrimidine dehydrogenase	MESH:C031368	1806	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|amod|END_ENTITY	The effect of sorivudine on dihydropyrimidine_dehydrogenase activity in patients with acute_herpes_zoster .
19429059	0	sortilin	36,44	NTR	53,56	sortilin	NTR	null	24596(Tax:10116)	Chemical	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunohistochemical localization of sortilin and p75 -LRB- NTR -RRB- in normal and ischemic rat retina .
19060406	0	soyasaponin_I	49,62	renin	82,87	soyasaponin I	renin	MESH:C056684	5972	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|compound|END_ENTITY	Isolation of human renin inhibitor from soybean : soyasaponin_I is the novel human renin inhibitor in soybean .
8646830	0	sparteine	101,110	CYP2D6	25,31	sparteine	CYP2D6	MESH:D013034	1565	Chemical	Gene	comparison|nmod|START_ENTITY Assessment|dep|comparison Assessment|nmod|activity activity|compound|END_ENTITY	Assessment of individual CYP2D6 activity in extensive metabolizers with renal_failure : comparison of sparteine and dextromethorphan .
6081806	0	sparteine	12,21	acetylcholinesterase	65,85	sparteine	acetylcholinesterase	MESH:D013034	83817(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|amod|END_ENTITY	-LSB- Effects of sparteine , lupanine and some of their derivatives on acetylcholinesterase activity of the rat brain -RSB- .
3536704	0	sparteine_sulfate	10,27	insulin	31,38	sparteine sulfate	insulin	MESH:D013034	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of sparteine_sulfate on insulin secretion in normal men .
3651110	0	spermatozoal_ATP	28,44	kallikrein	14,24	spermatozoal ATP	kallikrein	null	9622	Chemical	Gene	parameters|compound|START_ENTITY effect|nmod|parameters effect|nmod|END_ENTITY	The effect of kallikrein on spermatozoal_ATP and other semen parameters .
22662273	0	spermidine	10,20	alpha-synuclein	55,70	spermidine	alpha-synuclein	MESH:D013095	6622	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of spermidine on misfolding and interactions of alpha-synuclein .
12788913	1	spermidine	64,74	deoxyhypusine_synthase	115,137	spermidine	deoxyhypusine synthase	MESH:D013095	1725	Chemical	Gene	Generation|nmod|START_ENTITY Generation|nmod|END_ENTITY	Generation of spermidine or homospermidine from deoxyhypusine by deoxyhypusine_synthase .
3036091	0	spermidine	50,60	ornithine_decarboxylase	14,37	spermidine	ornithine decarboxylase	MESH:D013095	18263(Tax:10090)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Regulation of ornithine_decarboxylase activity by spermidine and the spermidine analogue N1N8-bis -LRB- ethyl -RRB- spermidine .
14681975	0	spermine	11,19	ATPase	55,61	spermine	ATPase	MESH:D013096	1769	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|END_ENTITY	-LSB- Effect of spermine on activity of purified Ca2 + , Mg2 + - ATPase from plasma membranes of myometrium cells -RSB- .
23418509	0	spermine	35,43	LFA-1	15,20	spermine	LFA-1	MESH:D013096	3683	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Suppression of LFA-1 expression by spermine is associated with enhanced methylation of ITGAL , the LFA-1 promoter area .
23418509	0	spermine	35,43	LFA-1	98,103	spermine	LFA-1	MESH:D013096	3683	Chemical	Gene	expression|nmod|START_ENTITY Suppression|nmod|expression associated|nsubjpass|Suppression associated|nmod|methylation methylation|nmod|ITGAL ITGAL|appos|area area|compound|END_ENTITY	Suppression of LFA-1 expression by spermine is associated with enhanced methylation of ITGAL , the LFA-1 promoter area .
9225134	0	spermine	101,109	interleukin-6	28,41	spermine	interleukin-6	MESH:D013096	24498(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Role Role|nmod|END_ENTITY	Role of interleukin-1_beta , interleukin-6 , and TNF-alpha in intestinal maturation induced by dietary spermine in rats .
21372394	0	spermine	66,74	ovalbumin	46,55	spermine	ovalbumin	MESH:D013096	282665(Tax:10090)	Chemical	Gene	caused|nmod|START_ENTITY END_ENTITY|acl|caused	Enhancement of gastrointestinal absorption of ovalbumin caused by spermine induces an increase in plasma histamine levels in mice sensitized to ovalbumin .
9346303	0	spermine	68,76	phospholipase_C_delta1	27,49	spermine	phospholipase C delta1	MESH:D013096	5333	Chemical	Gene	requirements|nmod|START_ENTITY requirements|nmod|END_ENTITY	Structural requirements of phospholipase_C_delta1 for regulation by spermine , sphingosine and sphingomyelin .
2250564	0	spermine	10,18	protein_kinase_C	37,53	spermine	protein kinase C	MESH:D013096	112476	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of spermine on association of protein_kinase_C with phospholipid vesicles .
3091078	0	spermine	24,32	thrombin	140,148	spermine	thrombin	MESH:D013096	2147	Chemical	Gene	effects|nmod|START_ENTITY effects|acl|END_ENTITY	Differential effects of spermine on aggregation , inositol_phosphate formation and protein phosphorylation in human platelets in response to thrombin , arachidonic_acid and lysophosphatidic_acid .
3978721	0	spermine	11,19	transferrin	23,34	spermine	transferrin	MESH:D013096	100009267(Tax:9986)	Chemical	Gene	START_ENTITY|nmod|uptake uptake|compound|END_ENTITY	Effects of spermine on transferrin and iron uptake by reticulocytes : I. Action on the endocytic uptake of transferrin .
2891356	0	spermine	10,18	tyrosine_hydroxylase	22,42	spermine	tyrosine hydroxylase	MESH:D013096	280707(Tax:9913)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effect of spermine on tyrosine_hydroxylase activity before and after phosphorylation by cyclic_AMP-dependent protein kinase .
11698173	0	spheroids	85,94	Cytochrome_P450	0,15	spheroids	Cytochrome P450	null	25251(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Cytochrome_P450 activity in control and induced long-term cultures of rat hepatocyte spheroids .
18459163	1	sphingolipid	118,130	CERT	150,154	sphingolipid	CERT	CHEBI:26739	10087	Chemical	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	Recent discoveries of two sphingolipid transfer proteins , CERT and FAPP2 , have brought the field of sphingolipid metabolism to a more dynamic stage .
19734127	0	sphingolipid	30,42	ENOX2	83,88	sphingolipid	ENOX2	CHEBI:26739	10495	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Downstream targets of altered sphingolipid metabolism in response to inhibition of ENOX2 by phenoxodiol .
17101780	0	sphingolipid	58,70	Slm1	29,33	sphingolipid	Slm1	CHEBI:26739	854701(Tax:4932)	Chemical	Gene	targets|nmod|START_ENTITY targets|nsubj|END_ENTITY	The yeast PH domain proteins Slm1 and Slm2 are targets of sphingolipid signaling during the response to heat stress .
18522410	0	sphingolipid	14,26	milk_fat_globule_membrane	63,88	sphingolipid	milk fat globule membrane	CHEBI:26739	281913(Tax:9913)	Chemical	Gene	compositions|amod|START_ENTITY compositions|nmod|END_ENTITY	Phospholipid , sphingolipid , and fatty_acid compositions of the milk_fat_globule_membrane are modified by diet .
16691509	0	sphingolipid	65,77	tyrosinase	30,40	sphingolipid	tyrosinase	CHEBI:26739	7299	Chemical	Gene	START_ENTITY|nsubj|activation activation|nmod|gene gene|amod|END_ENTITY	Transcriptional activation of tyrosinase gene by human placental sphingolipid .
26459425	0	sphingolipid_psychosine	70,93	connexin43	31,41	sphingolipid psychosine	connexin43	null	14609(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nmod|effects	Krabbe_disease : involvement of connexin43 in the apoptotic effects of sphingolipid_psychosine on mouse oligodendrocyte precursors .
18188632	0	sphingolipids	43,56	PC-3	82,86	sphingolipids	PC-3	MESH:D013107	7832	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Apoptotic effects of dietary and synthetic sphingolipids in androgen-independent -LRB- PC-3 -RRB- prostate_cancer cells .
17760463	0	sphingolipids	9,22	apolipoprotein_E	43,59	sphingolipids	apolipoprotein E	MESH:D013107	348	Chemical	Gene	START_ENTITY|xcomp|regulate regulate|dobj|secretion secretion|compound|END_ENTITY	Cellular sphingolipids regulate macrophage apolipoprotein_E secretion .
15950537	0	sphingolipids	46,59	phospholipase_A2	77,93	sphingolipids	phospholipase A2	MESH:D013107	18784(Tax:10090)	Chemical	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	2n-fatty_acids from phosphatidylcholine label sphingolipids -- a novel role of phospholipase_A2 ?
23560799	0	sphingomyelin	17,30	ABCA8	0,5	sphingomyelin	ABCA8	CHEBI:17636	10351	Chemical	Gene	production|compound|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	ABCA8 stimulates sphingomyelin production in oligodendrocytes .
9251249	0	sphingomyelin	10,23	PLC_delta_1	81,92	sphingomyelin	PLC delta 1	CHEBI:17636	5333	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|nmod|END_ENTITY	Effect of sphingomyelin and its metabolites on the activity of human recombinant PLC_delta_1 .
10336612	0	sphingomyelin	43,56	Platelet-activating_factor	0,26	sphingomyelin	Platelet-activating factor	CHEBI:17636	9768	Chemical	Gene	metabolism|compound|START_ENTITY modulates|dobj|metabolism modulates|nsubj|END_ENTITY	Platelet-activating_factor modulates brain sphingomyelin metabolism .
17449912	0	sphingomyelin	60,73	SMS1	29,33	sphingomyelin	SMS1	CHEBI:17636	259230	Chemical	Gene	homeostasis|compound|START_ENTITY required|nmod|homeostasis required|nsubjpass|END_ENTITY	Both sphingomyelin synthases SMS1 and SMS2 are required for sphingomyelin homeostasis and growth in human HeLa cells .
25167836	0	sphingomyelin	45,58	endothelial_lipase	14,32	sphingomyelin	endothelial lipase	CHEBI:17636	9388	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activity activity|amod|END_ENTITY	Inhibition of endothelial_lipase activity by sphingomyelin in the lipoproteins .
26193433	0	sphingomyelin	41,54	hepatic_lipase	14,28	sphingomyelin	hepatic lipase	CHEBI:17636	3990	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|activity activity|amod|END_ENTITY	Regulation of hepatic_lipase activity by sphingomyelin in plasma lipoproteins .
22370449	0	sphingomyelin	111,124	lecithin-cholesterol_acyltransferase	128,164	sphingomyelin	lecithin-cholesterol acyltransferase	CHEBI:17636	16816(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Regulation of plasma cholesterol esterification by sphingomyelin : effect of physiological variations of plasma sphingomyelin on lecithin-cholesterol_acyltransferase activity .
22370449	0	sphingomyelin	51,64	lecithin-cholesterol_acyltransferase	128,164	sphingomyelin	lecithin-cholesterol acyltransferase	CHEBI:17636	16816(Tax:10090)	Chemical	Gene	esterification|nmod|START_ENTITY Regulation|nmod|esterification Regulation|dep|effect effect|nmod|variations variations|nmod|sphingomyelin sphingomyelin|nmod|activity activity|amod|END_ENTITY	Regulation of plasma cholesterol esterification by sphingomyelin : effect of physiological variations of plasma sphingomyelin on lecithin-cholesterol_acyltransferase activity .
10903482	0	sphingomyelin	45,58	lipoprotein_lipase	14,32	sphingomyelin	lipoprotein lipase	CHEBI:17636	4023	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Inhibition of lipoprotein_lipase activity by sphingomyelin : role of membrane surface structure .
9421185	0	sphingomyelin	20,33	lipoprotein_lipase	101,119	sphingomyelin	lipoprotein lipase	CHEBI:17636	4023	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|hydrolysis hydrolysis|nmod|particle particle|acl|triolein triolein|nmod|END_ENTITY	Combined effects of sphingomyelin and cholesterol on the hydrolysis of emulsion particle triolein by lipoprotein_lipase .
6174152	0	sphingomyelin	81,94	myelin_basic_protein	22,42	sphingomyelin	myelin basic protein	CHEBI:17636	618684(Tax:9913)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of bovine myelin_basic_protein on the phase transition properties of sphingomyelin .
8376408	0	sphingomyelin	40,53	nuclear_factor_kappa_B	70,92	sphingomyelin	nuclear factor kappa B	CHEBI:17636	4790	Chemical	Gene	translocation|amod|START_ENTITY translocation|compound|END_ENTITY	Tumor necrosis factor activation of the sphingomyelin pathway signals nuclear_factor_kappa_B translocation in intact HL-60 cells .
9523016	0	sphingomyelin	45,58	phospholipase_C_delta_1	62,85	sphingomyelin	phospholipase C delta 1	CHEBI:17636	281986(Tax:9913)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|amod|END_ENTITY	The effect of different molecular species of sphingomyelin on phospholipase_C_delta_1 activity .
17049047	0	sphingomyelin	128,141	sphingomyelin_synthase_1	76,100	sphingomyelin	sphingomyelin synthase 1	CHEBI:17636	208449(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Resistance to alkyl-lysophospholipid-induced apoptosis due to downregulated sphingomyelin_synthase_1 expression with consequent sphingomyelin - and cholesterol-deficiency in lipid rafts .
24342046	0	sphingosine	15,26	AP-1	0,4	sphingosine	AP-1	MESH:D013110	24516(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	AP-1 regulates sphingosine kinase 1 expression in a positive feedback manner in glomerular mesangial cells exposed to high glucose .
11258664	0	sphingosine	14,25	B2_receptor	51,62	sphingosine	B2 receptor	MESH:D013110	624	Chemical	Gene	Activation|nmod|START_ENTITY kinase|nsubj|Activation kinase|nmod|END_ENTITY	Activation of sphingosine kinase by the bradykinin B2_receptor and its implication in regulation of the ERK/MAP kinase pathway .
8752836	0	sphingosine	45,56	Th1	62,65	sphingosine	Th1	MESH:D013110	57314(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|cells cells|amod|END_ENTITY	Th2 suppressor cells are more susceptible to sphingosine than Th1 cells in murine contact photosensitivity .
9826677	0	sphingosine	77,88	Tumor_necrosis_factor-alpha	0,27	sphingosine	Tumor necrosis factor-alpha	MESH:D013110	7124	Chemical	Gene	pathway|amod|START_ENTITY induces|nmod|pathway induces|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha induces adhesion molecule expression through the sphingosine kinase pathway .
17822721	0	sphingosine	70,81	adiponectin	9,20	sphingosine	adiponectin	MESH:D013110	9370	Chemical	Gene	pathway|amod|START_ENTITY induces|nmod|pathway induces|nsubj|END_ENTITY	Globular adiponectin induces adhesion molecule expression through the sphingosine kinase pathway in vascular endothelial cells .
8635587	0	sphingosine	40,51	bcl-2	15,20	sphingosine	bcl-2	MESH:D013110	596	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Suppression of bcl-2 gene expression by sphingosine in the apoptosis of human leukemic HL-60 cells during phorbol_ester-induced terminal differentiation .
26934645	0	sphingosine	100,111	desaturase	82,92	sphingosine	desaturase	MESH:D013110	8560	Chemical	Gene	kinase|amod|START_ENTITY END_ENTITY|nmod|kinase	Proteasomal degradation of sphingosine kinase 1 and inhibition of dihydroceramide desaturase by the sphingosine kinase inhibitors , SKi or ABC294640 , induces growth_arrest in androgen-independent LNCaP-AI prostate_cancer cells .
25264785	5	sphingosine	1029,1040	iSK	1059,1062	sphingosine	S1P	MESH:D013110	13609(Tax:10090)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Indeed , exposure to conditioned medium obtained from MSCs cultured in the presence of the selective sphingosine kinase inhibitor -LRB- iSK -RRB- , blocked increased cell proliferation caused by the conditioned medium from untreated MSCs , and the addition of exogenous S1P in the conditioned medium from MSCs pre-treated with iSK further increased myoblast proliferation .
9168154	0	sphingosine	40,51	phospholipase_C_delta1	14,36	sphingosine	phospholipase C delta1	MESH:D013110	5333	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of phospholipase_C_delta1 by sphingosine .
20220090	0	sphingosine	45,56	sphingosine_1-phosphate	18,41	sphingosine	sphingosine 1-phosphate	MESH:D013110	13609(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY END_ENTITY|nmod|kinase	Redistribution of sphingosine_1-phosphate by sphingosine kinase 2 contributes to lymphopenia .
7578580	0	sphingosine	116,127	tumor_necrosis_factor_alpha	54,81	sphingosine	tumor necrosis factor alpha	MESH:D013110	21926(Tax:10090)	Chemical	Gene	Correlation|nmod|START_ENTITY Correlation|nmod|END_ENTITY	-LSB- Correlation of cytotoxic activity of mutant forms of tumor_necrosis_factor_alpha with changes in the level of free sphingosine in murine liver -RSB- .
20508187	0	sphingosine-1-phosphate	87,110	Akt	141,144	sphingosine-1-phosphate	Akt	MESH:C060506	24185(Tax:10116)	Chemical	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	Isoflurane posttreatment reduces neonatal hypoxic-ischemic_brain_injury in rats by the sphingosine-1-phosphate / phosphatidylinositol-3-kinase / Akt pathway .
21543615	0	sphingosine-1-phosphate	47,70	BACE1	0,5	sphingosine-1-phosphate	BACE1	MESH:C060506	23621	Chemical	Gene	modulated|nmod|START_ENTITY modulated|nsubjpass|activity activity|compound|END_ENTITY	BACE1 activity is modulated by cell-associated sphingosine-1-phosphate .
23955082	0	sphingosine-1-phosphate	19,42	C-reactive_protein	55,73	sphingosine-1-phosphate	C-reactive protein	MESH:C060506	1401	Chemical	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	Inflammatory lipid sphingosine-1-phosphate upregulates C-reactive_protein via C/EBPb and potentiates breast_cancer progression .
9765227	0	sphingosine-1-phosphate	21,44	EDG1	0,4	sphingosine-1-phosphate	EDG1	MESH:C060506	1901	Chemical	Gene	receptor|amod|START_ENTITY receptor|nsubj|END_ENTITY	EDG1 is a functional sphingosine-1-phosphate receptor that is linked via a Gi/o to multiple signaling pathways , including phospholipase C activation , Ca2 + mobilization , Ras-mitogen-activated protein kinase activation , and adenylate cyclase inhibition .
11032855	0	sphingosine-1-phosphate	42,65	Edg-1	0,5	sphingosine-1-phosphate	Edg-1	MESH:C060506	13609(Tax:10090)	Chemical	Gene	receptor|nmod|START_ENTITY END_ENTITY|appos|receptor	Edg-1 , the G protein-coupled receptor for sphingosine-1-phosphate , is essential for vascular maturation .
20522601	0	sphingosine-1-phosphate	102,125	HDL3	0,4	sphingosine-1-phosphate	HDL3	MESH:C060506	53369	Chemical	Gene	role|nmod|START_ENTITY stimulates|parataxis|role stimulates|nsubj|END_ENTITY	HDL3 , but not HDL2 , stimulates plasminogen_activator_inhibitor-1 release from adipocytes : the role of sphingosine-1-phosphate .
12427546	0	sphingosine-1-phosphate	28,51	S1P5	67,71	sphingosine-1-phosphate	S1P5	MESH:C060506	53637	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of a human sphingosine-1-phosphate receptor gene -LRB- S1P5 -RRB- and its differential expression in LGL_leukemia .
24632890	0	sphingosine-1-phosphate	44,67	Sphingosine-1-phosphate_receptor_3	0,34	sphingosine-1-phosphate	Sphingosine-1-phosphate receptor 3	MESH:C060506	1903	Chemical	Gene	release|amod|START_ENTITY mediates|dobj|release mediates|nsubj|END_ENTITY	Sphingosine-1-phosphate_receptor_3 mediates sphingosine-1-phosphate induced release of weibel-palade bodies from endothelial cells .
26324848	0	sphingosine-1-phosphate	14,37	Spinster_2	0,10	sphingosine-1-phosphate	Spinster 2	MESH:C060506	216892(Tax:10090)	Chemical	Gene	transporter|amod|START_ENTITY END_ENTITY|appos|transporter	Spinster_2 , a sphingosine-1-phosphate transporter , plays a critical role in inflammatory and autoimmune diseases .
26324848	0	sphingosine-1-phosphate	14,37	Spinster_2	0,10	sphingosine-1-phosphate	Spinster 2	MESH:C060506	216892(Tax:10090)	Chemical	Gene	transporter|amod|START_ENTITY END_ENTITY|appos|transporter	Spinster_2 , a sphingosine-1-phosphate transporter , plays a critical role in inflammatory and autoimmune diseases .
19151362	0	sphingosine-1-phosphate	94,117	Stat3	38,43	sphingosine-1-phosphate	Stat3	MESH:C060506	25125(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Native and reconstituted HDL activate Stat3 in ventricular cardiomyocytes via ERK1/2 : role of sphingosine-1-phosphate .
24448174	0	sphingosine-1-phosphate	55,78	TNF-a	0,5	sphingosine-1-phosphate	TNF-a	MESH:C060506	21926(Tax:10090)	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|production production|amod|END_ENTITY	TNF-a production in NKT cell hybridoma is regulated by sphingosine-1-phosphate : implications for inflammation in atherosclerosis .
23041148	0	sphingosine-1-phosphate	20,43	a-smooth_muscle_actin	61,82	sphingosine-1-phosphate	a-smooth muscle actin	MESH:C060506	58	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Contrary effects of sphingosine-1-phosphate on expression of a-smooth_muscle_actin in transforming_growth_factor_b1-stimulated lung fibroblasts .
17008548	0	sphingosine-1-phosphate	87,110	phospholipase_A2	53,69	sphingosine-1-phosphate	phospholipase A2	MESH:C060506	151056	Chemical	Gene	receptors|amod|START_ENTITY END_ENTITY|nmod|receptors	The immunosuppressant drug FTY720 inhibits cytosolic phospholipase_A2 independently of sphingosine-1-phosphate receptors .
22315056	0	sphingosine-1-phosphate	12,35	sphingosine_kinase-1	52,72	sphingosine-1-phosphate	sphingosine kinase-1	MESH:C060506	8877	Chemical	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Circulating sphingosine-1-phosphate and erythrocyte sphingosine_kinase-1 activity as novel biomarkers for early_prostate_cancer detection .
25330231	0	sphingosine-1-phosphate	26,49	spns2	17,22	sphingosine-1-phosphate	spns2	MESH:C060506	124976	Chemical	Gene	transporter|amod|START_ENTITY END_ENTITY|appos|transporter	Critical role of spns2 , a sphingosine-1-phosphate transporter , in lung_cancer cell survival and migration .
20463015	0	sphingosine_1-phosophate	16,40	S1P1	53,57	sphingosine 1-phosophate	S1P1	null	1901	Chemical	Gene	receptor-1|amod|START_ENTITY receptor-1|appos|END_ENTITY	CD69 suppresses sphingosine_1-phosophate receptor-1 -LRB- S1P1 -RRB- function through interaction with membrane helix 4 .
20110355	0	sphingosine_1-phosphate	28,51	ABCC1	81,86	sphingosine 1-phosphate	ABCC1	MESH:C060506	4363	Chemical	Gene	cells|amod|START_ENTITY cells|nmod|END_ENTITY	Estradiol induces export of sphingosine_1-phosphate from breast_cancer cells via ABCC1 and ABCG2 .
16414356	0	sphingosine_1-phosphate	14,37	Bax	41,44	sphingosine 1-phosphate	Bax	MESH:C060506	581	Chemical	Gene	START_ENTITY|nmod|activities activities|amod|END_ENTITY	Regulation by sphingosine_1-phosphate of Bax and Bad activities during apoptosis in a MEK-dependent manner .
16636149	0	sphingosine_1-phosphate	37,60	EGFR	24,28	sphingosine 1-phosphate	EGFR	MESH:C060506	1956	Chemical	Gene	Edg-3|amod|START_ENTITY END_ENTITY|nmod|Edg-3	Estrogen transactivates EGFR via the sphingosine_1-phosphate receptor Edg-3 : the role of sphingosine_kinase-1 .
10679247	0	sphingosine_1-phosphate	20,43	Edg-6	0,5	sphingosine 1-phosphate	Edg-6	MESH:C060506	8698	Chemical	Gene	receptor|amod|START_ENTITY END_ENTITY|nmod|receptor	Edg-6 as a putative sphingosine_1-phosphate receptor coupling to Ca -LRB- 2 + -RRB- signaling pathway .
17098744	0	sphingosine_1-phosphate	51,74	Galpha12	0,8	sphingosine 1-phosphate	Galpha12	MESH:C060506	14673(Tax:10090)	Chemical	Gene	regulates|advcl|START_ENTITY regulates|nsubj|END_ENTITY	Galpha12 specifically regulates COX-2 induction by sphingosine_1-phosphate .
12039947	0	sphingosine_1-phosphate	30,53	Phospholipase_D	0,15	sphingosine 1-phosphate	Phospholipase D	MESH:C060506	2822	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Phospholipase_D activation by sphingosine_1-phosphate regulates interleukin-8 secretion in human bronchial epithelial cells .
16046470	0	sphingosine_1-phosphate	7,30	S1P	76,79	sphingosine 1-phosphate	S1P	MESH:C060506	13609(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY transduces|nsubj|receptor transduces|dobj|effects effects|nummod|END_ENTITY	Type 4 sphingosine_1-phosphate G protein-coupled receptor -LRB- S1P4 -RRB- transduces S1P effects on T cell proliferation and cytokine secretion without signaling migration .
17257496	0	sphingosine_1-phosphate	15,38	S1P	118,121	sphingosine 1-phosphate	S1P	MESH:C060506	13609(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY Involvement|nmod|receptor T|nsubj|Involvement T|dobj|cells cells|nmod|END_ENTITY	Involvement of sphingosine_1-phosphate -LRB- S1P -RRB- receptor type 1 and type 4 in migratory response of mouse T cells toward S1P .
17257496	0	sphingosine_1-phosphate	15,38	S1P	40,43	sphingosine 1-phosphate	S1P	MESH:C060506	13609(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Involvement of sphingosine_1-phosphate -LRB- S1P -RRB- receptor type 1 and type 4 in migratory response of mouse T cells toward S1P .
26615875	4	sphingosine_1-phosphate	597,620	S1P	622,625	sphingosine 1-phosphate	S1P	MESH:C060506	13609(Tax:10090)	Chemical	Gene	hepatic|amod|START_ENTITY hepatic|appos|END_ENTITY	Enforced overexpression of SphK1 or treatment with sphingosine_1-phosphate -LRB- S1P -RRB- markedly enhanced hepatic lipid accumulation .
12577307	0	sphingosine_1-phosphate	121,144	S1P2	59,63	sphingosine 1-phosphate	S1P2	MESH:C060506	9294	Chemical	Gene	G|advcl|START_ENTITY G|nsubj|regulation regulation|nmod|expression expression|nmod|END_ENTITY	Biochemical regulation of breast_cancer cell expression of S1P2 -LRB- Edg-5 -RRB- and S1P3 -LRB- Edg-3 -RRB- G protein-coupled receptors for sphingosine_1-phosphate .
14717991	0	sphingosine_1-phosphate	17,40	S1P2	104,108	sphingosine 1-phosphate	S1P2	MESH:C060506	9294	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|contraction contraction|nmod|END_ENTITY	Platelet-derived sphingosine_1-phosphate induces contraction of coronary artery smooth muscle cells via S1P2 .
16945494	0	sphingosine_1-phosphate	9,32	S1P2	4,8	sphingosine 1-phosphate	S1P2	MESH:C060506	14739(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	The S1P2 sphingosine_1-phosphate receptor is essential for auditory and vestibular function .
24292566	0	sphingosine_1-phosphate	15,38	S1P2	102,106	sphingosine 1-phosphate	S1P2	MESH:C060506	9294	Chemical	Gene	resistance|amod|START_ENTITY resistance|nmod|hepatocytes hepatocytes|nmod|receptor receptor|compound|END_ENTITY	Involvement of sphingosine_1-phosphate in palmitate-induced insulin resistance of hepatocytes via the S1P2 receptor subtype .
16046470	0	sphingosine_1-phosphate	7,30	S1P4	59,63	sphingosine 1-phosphate	S1P4	MESH:C060506	13611(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Type 4 sphingosine_1-phosphate G protein-coupled receptor -LRB- S1P4 -RRB- transduces S1P effects on T cell proliferation and cytokine secretion without signaling migration .
24333325	0	sphingosine_1-phosphate	10,33	S1P5	44,48	sphingosine 1-phosphate	S1P5	MESH:C060506	53637	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Extrinsic sphingosine_1-phosphate activates S1P5 and induces autophagy through generating endoplasmic reticulum stress in human prostate_cancer PC-3 cells .
21084291	0	sphingosine_1-phosphate	4,27	SPNS2	41,46	sphingosine 1-phosphate	SPNS2	MESH:C060506	568117(Tax:7955)	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	The sphingosine_1-phosphate transporter , SPNS2 , functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720 .
25049234	0	sphingosine_1-phosphate	61,84	TER	50,53	sphingosine 1-phosphate	TER	MESH:C060506	9524	Chemical	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	Dual functions of the trans-2-enoyl-CoA reductase TER in the sphingosine_1-phosphate metabolic pathway and in fatty_acid elongation .
17306937	0	sphingosine_1-phosphate	12,35	TNF-alpha	43,52	sphingosine 1-phosphate	TNF-alpha	MESH:C060506	7124	Chemical	Gene	START_ENTITY|nmod|induction induction|amod|END_ENTITY	The role of sphingosine_1-phosphate in the TNF-alpha induction of IL-8 gene expression in lung epithelial cells .
10453985	0	sphingosine_1-phosphate	10,33	phospholipase_D	83,98	sphingosine 1-phosphate	phospholipase D	MESH:C060506	2822	Chemical	Gene	Exogenous|amod|START_ENTITY stimulate|nsubj|Exogenous stimulate|dep|END_ENTITY	Exogenous sphingosine_1-phosphate and sphingosylphosphorylcholine do not stimulate phospholipase_D in C6 glioma cells .
14499732	0	sphingosine_1-phosphate	99,122	phospholipase_D	137,152	sphingosine 1-phosphate	phospholipase D	MESH:C060506	2822	Chemical	Gene	signalling|amod|START_ENTITY uncoupling|nmod|signalling results|nmod|uncoupling results|xcomp|END_ENTITY	Down-regulation of EDG5/S1P2 during myogenic differentiation results in the specific uncoupling of sphingosine_1-phosphate signalling to phospholipase_D .
2912589	0	sphingosine_sulfate	121,140	ornithine_decarboxylase	31,54	sphingosine sulfate	ornithine decarboxylase	null	18263(Tax:10090)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|induction induction|nmod|activity activity|amod|END_ENTITY	Inhibition of the induction of ornithine_decarboxylase activity by 12-O-tetradecanoylphorbol-13-acetate in mouse skin by sphingosine_sulfate .
15946238	0	sphingosylphosphorylcholine	59,86	connective_tissue_growth_factor	13,44	sphingosylphosphorylcholine	connective tissue growth factor	MESH:C005356	1490	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|expression expression|compound|END_ENTITY	Induction of connective_tissue_growth_factor expression by sphingosylphosphorylcholine in cultured human skin fibroblasts .
12847558	0	spiradoline	30,41	kappa-opioid_receptor	66,87	spiradoline	kappa-opioid receptor	MESH:C051272	4986	Chemical	Gene	properties|nmod|START_ENTITY review|nmod|properties review|dep|END_ENTITY	A review of the properties of spiradoline : a potent and selective kappa-opioid_receptor agonist .
9138682	0	spiradoline	15,26	kappa-opioid_receptor	41,62	spiradoline	kappa-opioid receptor	MESH:C051272	4986	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	The effects of spiradoline -LRB- U-62066E -RRB- , a kappa-opioid_receptor agonist , on neuroendocrine function in man .
1659438	0	spiradoline	32,43	kappa_opioid_receptor	58,79	spiradoline	kappa opioid receptor	MESH:C051272	4986	Chemical	Gene	action|nmod|START_ENTITY Mechanism|nmod|action Mechanism|dep|agonist agonist|compound|END_ENTITY	Mechanism of diuretic action of spiradoline -LRB- U-62066E -RRB- -- a kappa_opioid_receptor agonist in the human .
1660789	0	spiradoline	21,32	kappa_opioid_receptor	36,57	spiradoline	kappa opioid receptor	MESH:C051272	100152118(Tax:9823)	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Inhibitory effect of spiradoline , a kappa_opioid_receptor agonist , on Ca2 + induced contraction and the intracellular Ca2 + concentration in porcine coronary artery .
10499562	0	spirapril	95,104	ACE	0,3	spirapril	ACE	MESH:C052555	1636	Chemical	Gene	focus|nmod|START_ENTITY inhibition|dep|focus inhibition|compound|END_ENTITY	ACE inhibition in chronic_renal_failure and in the treatment of diabetic_nephropathy : focus on spirapril .
12613273	0	spirapril	28,37	ACE	14,17	spirapril	ACE	MESH:C052555	1636	Chemical	Gene	START_ENTITY|nsubj|Influence Influence|nmod|inhibitor inhibitor|compound|END_ENTITY	-LSB- Influence of ACE inhibitor spirapril on left_ventricular_hypertrophy -RSB- .
8638865	0	spirapril	116,125	ACE	0,3	spirapril	ACE	MESH:C052555	1636	Chemical	Gene	treatment|nmod|START_ENTITY improves|nmod|treatment improves|nsubj|inhibition inhibition|compound|END_ENTITY	ACE inhibition with spirapril improves diastolic function at rest independent of vasodilation during treatment with spirapril in mild to moderate hypertension .
8638865	0	spirapril	20,29	ACE	0,3	spirapril	ACE	MESH:C052555	1636	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	ACE inhibition with spirapril improves diastolic function at rest independent of vasodilation during treatment with spirapril in mild to moderate hypertension .
8061851	0	spirapril	46,55	Angiotensin-converting_enzyme	0,29	spirapril	Angiotensin-converting enzyme	MESH:C052555	1636	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Angiotensin-converting_enzyme inhibition with spirapril in patients with coronary_artery_disease .
2544729	0	spirapril	42,51	Angiotensin_converting_enzyme	0,29	spirapril	Angiotensin converting enzyme	MESH:C052555	24310(Tax:10116)	Chemical	Gene	compounds|amod|START_ENTITY inhibitors|dep|compounds inhibitors|amod|END_ENTITY	Angiotensin_converting_enzyme inhibitors : spirapril and related compounds .
3036028	0	spirapril	64,73	Angiotensin_converting_enzyme	0,29	spirapril	Angiotensin converting enzyme	MESH:C052555	24310(Tax:10116)	Chemical	Gene	activity|dep|START_ENTITY activity|amod|END_ENTITY	Angiotensin_converting_enzyme inhibitory activity of SCH_33844 -LRB- spirapril -RRB- in rats , dogs and monkeys .
16710253	0	spirapril	134,143	angiotensin_converting_enzyme	94,123	spirapril	angiotensin converting enzyme	MESH:C052555	1636	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Advantages of long-term controlled stepwise therapy of arterial_hypertension with the use of angiotensin_converting_enzyme inhibitor spirapril -RSB- .
8824693	0	spirapril	73,82	angiotensin_converting_enzyme	29,58	spirapril	angiotensin converting enzyme	MESH:C052555	1636	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|Effects Effects|nmod|END_ENTITY	Effects of acute and chronic angiotensin_converting_enzyme inhibition by spirapril on cardiovascular regulation in essential hypertensive patients .
2833190	0	spiraprilic_acid	11,27	angiotensin_converting_enzyme	32,61	spiraprilic acid	angiotensin converting enzyme	MESH:C056109	610668(Tax:9615)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effects of spiraprilic_acid , an angiotensin_converting_enzyme inhibitor , on large artery compliance in anesthetized dogs .
21565498	0	spiro-3-piperidyl	44,61	MK2	78,81	spiro-3-piperidyl	MK2	null	9261	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Discovery of selective and orally available spiro-3-piperidyl ATP-competitive MK2 inhibitors .
16844377	0	spiro-piperidines	4,21	5-HT2B_receptor	25,40	spiro-piperidines	5-HT2B receptor	null	3357	Chemical	Gene	START_ENTITY|nmod|antagonists antagonists|amod|END_ENTITY	New spiro-piperidines as 5-HT2B_receptor antagonists .
22071301	0	spirocyclic_piperidines	97,120	Renin	0,5	spirocyclic piperidines	Renin	null	5972	Chemical	Gene	series|nmod|START_ENTITY design|nmod|series inhibitors|dep|design inhibitors|compound|END_ENTITY	Renin inhibitors for the treatment of hypertension : design and optimization of a novel series of spirocyclic_piperidines .
24780121	0	spirocyclic_pyranochromene	62,88	BACE1	89,94	spirocyclic pyranochromene	BACE1	null	29392(Tax:10116)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Synthesis , characterization , and PK/PD studies of a series of spirocyclic_pyranochromene BACE1 inhibitors .
10093002	0	spiroglumide	11,23	gastrin_receptor	27,43	spiroglumide	gastrin receptor	MESH:C076954	887	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Effects of spiroglumide , a gastrin_receptor antagonist , on acid secretion in humans .
19243937	0	spiroindoline	42,55	NPY_Y5_receptor	56,71	spiroindoline	NPY Y5 receptor	null	25340(Tax:10116)	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|amod|END_ENTITY	Identification of novel and orally active spiroindoline NPY_Y5_receptor antagonists .
24997575	0	spiroindolinone	34,49	MDM2	50,54	spiroindolinone	MDM2	null	4193	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	Discovery of potent and selective spiroindolinone MDM2 inhibitor , RO8994 , for cancer therapy .
11306716	0	spirolactones	41,54	androgen_receptor	63,80	spirolactones	androgen receptor	null	367	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Antimineralocorticoid 11beta-substituted spirolactones exhibit androgen_receptor agonistic activity : a structure function study .
25683504	0	spironolactone	41,55	ACE	70,73	spironolactone	ACE	MESH:D013148	1636	Chemical	Gene	therapy|amod|START_ENTITY therapy|compound|END_ENTITY	Risk of hyperkalemia and combined use of spironolactone and long-term ACE inhibitor/angiotensin receptor blocker therapy in heart_failure using real-life data : a population - and insurance-based cohort .
16899309	0	spironolactone	10,24	C-reactive_protein	28,46	spironolactone	C-reactive protein	MESH:D013148	1401	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|amod|END_ENTITY	Effect of spironolactone on C-reactive_protein levels in patients with heart_disease .
11146369	0	spironolactone	50,64	CYP11B2	0,7	spironolactone	CYP11B2	MESH:D013148	24294(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	CYP11B2 expression in rat liver and the effect of spironolactone on hepatic fibrogenesis .
21459122	0	spironolactone	64,78	Pregnane_X_receptor	0,19	spironolactone	Pregnane X receptor	MESH:D013148	8856	Chemical	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Pregnane_X_receptor mediates the induction of P-glycoprotein by spironolactone in HepG2 cells .
20416221	0	spironolactone	11,25	Toll-like_receptor_4	47,67	spironolactone	Toll-like receptor 4	MESH:D013148	29260(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of spironolactone on the expression of Toll-like_receptor_4 in renal tubular epithelia cells exposed to high glucose -RSB- .
12818378	0	spironolactone	10,24	UDP-glucuronosyltransferase	58,85	spironolactone	UDP-glucuronosyltransferase	MESH:D013148	24862(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	Effect of spironolactone on the expression of rat hepatic UDP-glucuronosyltransferase .
23881739	0	spironolactone	99,113	androgen_receptor	37,54	spironolactone	androgen receptor	MESH:D013148	100049344(Tax:8090)	Chemical	Gene	sensitivity|advmod|START_ENTITY sensitivity|nmod|agonist agonist|compound|END_ENTITY	Cross-species sensitivity to a novel androgen_receptor agonist of potential environmental concern , spironolactone .
487244	0	spironolactone	15,29	androgen_receptor	44,61	spironolactone	androgen receptor	MESH:D013148	24208(Tax:10116)	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of spironolactone with rat skin androgen_receptor .
11788231	0	spironolactone	12,26	angiotensin-converting_enzyme	30,59	spironolactone	angiotensin-converting enzyme	MESH:D013148	24310(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|amod|END_ENTITY	Addition of spironolactone to angiotensin-converting_enzyme inhibition in heart_failure improves endothelial vasomotor dysfunction : role of vascular superoxide anion formation and endothelial nitric_oxide synthase expression .
12484506	0	spironolactone	30,44	angiotensin-converting_enzyme	68,97	spironolactone	angiotensin-converting enzyme	MESH:D013148	1636	Chemical	Gene	START_ENTITY|nmod|conjunction conjunction|nmod|inhibitor inhibitor|amod|END_ENTITY	Relative long-term effects of spironolactone in conjunction with an angiotensin-converting_enzyme inhibitor on left ventricular mass and diastolic function in patients with essential hypertension .
16555582	0	spironolactone	31,45	angiotensin-converting_enzyme	66,95	spironolactone	angiotensin-converting enzyme	MESH:D013148	24310(Tax:10116)	Chemical	Gene	mechanisms|nmod|START_ENTITY associated|nsubj|mechanisms associated|nmod|kinases kinases|amod|END_ENTITY	Cardioprotective mechanisms of spironolactone associated with the angiotensin-converting_enzyme / epidermal_growth_factor_receptor / extracellular signal-regulated kinases , NAD -LRB- P -RRB- H oxidase/lectin-like oxidized low-density lipoprotein receptor-1 , and Rho-kinase pathways in aldosterone/salt-induced hypertensive rats .
17699214	0	spironolactone	92,106	angiotensin-converting_enzyme	172,201	spironolactone	angiotensin-converting enzyme	MESH:D013148	1636	Chemical	Gene	START_ENTITY|nmod|therapy therapy|amod|END_ENTITY	Double-blind , placebo-controlled study on the effect of the aldosterone receptor antagonist spironolactone in patients who have persistent proteinuria and are on long-term angiotensin-converting_enzyme inhibitor therapy , with or without an angiotensin II receptor blocker .
19095597	0	spironolactone	10,24	angiotensin-converting_enzyme	94,123	spironolactone	angiotensin-converting enzyme	MESH:D013148	1636	Chemical	Gene	therapy|amod|START_ENTITY Effect|nmod|therapy Effect|acl|treated treated|nmod|inhibitors inhibitors|amod|END_ENTITY	Effect of spironolactone therapy on albuminuria in patients with type 2 diabetes treated with angiotensin-converting_enzyme inhibitors .
7503007	0	spironolactone	18,32	angiotensin-converting_enzyme	39,68	spironolactone	angiotensin-converting enzyme	MESH:D013148	1636	Chemical	Gene	adding|dobj|START_ENTITY adding|nmod|inhibitor inhibitor|amod|END_ENTITY	Effects of adding spironolactone to an angiotensin-converting_enzyme inhibitor in chronic congestive_heart_failure secondary to coronary_artery_disease .
8888663	0	spironolactone	17,31	angiotensin-converting_enzyme	44,73	spironolactone	angiotensin-converting enzyme	MESH:D013148	1636	Chemical	Gene	Effectiveness|nmod|START_ENTITY added|nsubj|Effectiveness added|nmod|inhibitor inhibitor|amod|END_ENTITY	Effectiveness of spironolactone added to an angiotensin-converting_enzyme inhibitor and a loop diuretic for severe chronic congestive_heart_failure -LRB- the Randomized Aldactone Evaluation Study -LSB- RALES -RSB- -RRB- .
11300427	0	spironolactone	10,24	brain_natriuretic_peptide	35,60	spironolactone	brain natriuretic peptide	MESH:D013148	4879	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of spironolactone on plasma brain_natriuretic_peptide and left ventricular remodeling in patients with congestive_heart_failure .
12942029	0	spironolactone	41,55	brain_natriuretic_peptide	59,84	spironolactone	brain natriuretic peptide	MESH:D013148	4879	Chemical	Gene	START_ENTITY|nmod|plasma plasma|amod|END_ENTITY	Effects of the addition of a low dose of spironolactone on brain_natriuretic_peptide plasma level and cardiopulmonary function in patients with moderate congestive_heart_failure .
24739800	0	spironolactone	9,23	fibulin-1	39,48	spironolactone	fibulin-1	MESH:D013148	2192	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|levels levels|amod|END_ENTITY	Low-dose spironolactone reduces plasma fibulin-1 levels in patients with type 2 diabetes and resistant hypertension .
411668	0	spironolactone	105,119	renin	138,143	spironolactone	renin	MESH:D013148	5972	Chemical	Gene	START_ENTITY|nmod|patients patients|compound|END_ENTITY	Renin levels and spironolactone treatment in general practice : similar blood pressure lowering effect of spironolactone in low and normal renin patients .
699476	0	spironolactone	30,44	renin	55,60	spironolactone	renin	MESH:D013148	5972	Chemical	Gene	START_ENTITY|nmod|hypertension hypertension|compound|END_ENTITY	Antihypertensive responses to spironolactone in normal renin hypertension .
7562907	0	spiropiperidines	4,20	NK2_receptor	68,80	spiropiperidines	NK2 receptor	null	100720631	Chemical	Gene	START_ENTITY|nmod|antagonists antagonists|amod|END_ENTITY	New spiropiperidines as potent and selective non-peptide tachykinin NK2_receptor antagonists .
19464889	0	spiropiperidines	25,41	NPY_Y5_receptor	45,60	spiropiperidines	NPY Y5 receptor	null	25340(Tax:10116)	Chemical	Gene	derivatives|nmod|START_ENTITY derivatives|nmod|antagonists antagonists|amod|END_ENTITY	Aryl_urea derivatives of spiropiperidines as NPY_Y5_receptor antagonists .
17935984	0	spiropyrrolidine_pyrimidinetrione	18,51	MMP-13	66,72	spiropyrrolidine pyrimidinetrione	MMP-13	null	171052(Tax:10116)	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|nmod|END_ENTITY	Potent , selective spiropyrrolidine_pyrimidinetrione inhibitors of MMP-13 .
8027986	0	spirosuccinimide	6,22	aldose_reductase	23,39	spirosuccinimide	aldose reductase	null	616199(Tax:9913)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Novel spirosuccinimide aldose_reductase inhibitors derived from isoquinoline-1 ,3 - diones : 2 - -LSB- -LRB- 4-bromo-2-fluorophenyl -RRB- methyl -RSB- -6 - _ fluorospiro -LSB- isoquinoline-4 -LRB- 1H -RRB- ,3 ' - pyrrolidine -RSB- -1,2 ' ,3,5 ' -LRB- 2H -RRB- - tetrone and congeners .
9467753	0	splenopentin	54,66	IL-2	15,19	splenopentin	IL-2	MESH:C041898	3558	Chemical	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	Stimulation of IL-2 production and CD2R expression by splenopentin analogs .
8505137	0	splenopentin	14,26	SP-5	31,35	splenopentin	SP-5	MESH:C041898	389058	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of splenopentin -LRB- DA SP-5 -RRB- on in vitro myelopoiesis and on AZT-induced bone_marrow_toxicity .
10209263	0	squalene	34,42	ERG9	58,62	squalene	ERG9	MESH:D013185	856597(Tax:4932)	Chemical	Gene	gene|amod|START_ENTITY regulation|nmod|gene regulation|appos|END_ENTITY	Transcriptional regulation of the squalene synthase gene -LRB- ERG9 -RRB- in the yeast Saccharomyces_cerevisiae .
11342098	0	squalene	36,44	ERG9	55,59	squalene	ERG9	MESH:D013185	856597(Tax:4932)	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	Positive and negative regulation of squalene synthase -LRB- ERG9 -RRB- , an ergosterol biosynthetic gene , in Saccharomyces_cerevisiae .
1807826	0	squalene	86,94	ERG9	39,43	squalene	ERG9	MESH:D013185	856597(Tax:4932)	Chemical	Gene	synthetase|amod|START_ENTITY encoding|dobj|synthetase structure|acl|encoding structure|nmod|gene gene|compound|END_ENTITY	Isolation and primary structure of the ERG9 gene of Saccharomyces_cerevisiae encoding squalene synthetase .
8020937	0	squalene	20,28	FDFT1	44,49	squalene	FDFT1	MESH:D013185	2222	Chemical	Gene	synthase|amod|START_ENTITY gene|amod|synthase gene|appos|END_ENTITY	Localization of the squalene synthase gene -LRB- FDFT1 -RRB- to human chromosome 8p22-p23 .1 .
11226224	0	squalene	102,110	Supernatant_protein_factor	0,26	squalene	Supernatant protein factor	MESH:D013185	116486(Tax:10116)	Chemical	Gene	protein|amod|START_ENTITY protein|nsubj|END_ENTITY	Supernatant_protein_factor , which stimulates the conversion of squalene to lanosterol , is a cytosolic squalene transfer protein and enhances cholesterol biosynthesis .
10649449	0	squalene	56,64	erg9	149,153	squalene	erg9	MESH:D013185	856597(Tax:4932)	Chemical	Gene	START_ENTITY|dobj|complementation complementation|nmod|mutation mutation|amod|END_ENTITY	Cloning and characterization of the Yarrowia_lipolytica squalene synthase -LRB- SQS1 -RRB- gene and functional complementation of the Saccharomyces_cerevisiae erg9 mutation .
25987292	0	squalene	61,69	supernatant_protein_factor	95,121	squalene	supernatant protein factor	MESH:D013185	23541	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Structural insights on cholesterol endosynthesis : Binding of squalene and 2,3-oxidosqualene to supernatant_protein_factor .
15033454	0	squalene	55,63	supernatant_protein_factor-like_protein	4,43	squalene	supernatant protein factor-like protein	MESH:D013185	64543(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|stimulates stimulates|compound|END_ENTITY	Rat supernatant_protein_factor-like_protein stimulates squalene monooxygenase and is activated by protein kinase A. Rat supernatant_protein_factor-like_protein -LRB- SPF2 -RRB- shares 90 % sequence identity with rat SPF and 77 % identity with human SPF , both of which have been shown to stimulate squalene monooxygenase in the cholesterol biosynthetic pathway .
24840537	0	stachydrine	14,25	caspase-12	47,57	stachydrine	caspase-12	CHEBI:35280	156117(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|nmod|END_ENTITY	The effect of stachydrine on the expression of caspase-12 in rats with unilateral ureteral_obstruction .
7482625	0	stanazolol	63,73	CD8	18,21	stanazolol	CD8	MESH:D013197	925	Chemical	Gene	+|nmod|START_ENTITY +|nsubj|END_ENTITY	A decreasing CD4 + / CD8 + ratio after one month of treatment with stanazolol in postmenopausal women .
21257611	0	stanol	70,76	apoE	104,108	stanol	apoE	null	11816(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Differential effects on inhibition of cholesterol absorption by plant stanol and plant sterol_esters in apoE - / - mice .
11772951	0	stanol_esters	17,30	LDL_receptor	34,46	stanol esters	LDL receptor	null	3949	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effects of plant stanol_esters on LDL_receptor protein expression and on LDL_receptor and HMG-CoA_reductase mRNA expression in mononuclear blood cells of healthy men and women .
6468473	0	stanozolol	10,20	delta-aminolaevulinic_acid_synthase	24,59	stanozolol	delta-aminolaevulinic acid synthase	MESH:D013197	211	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	Effect of stanozolol on delta-aminolaevulinic_acid_synthase and hepatic monooxygenase activity in man and rat .
6448164	0	stanozolol	35,45	tissue_plasminogen_activator	49,77	stanozolol	tissue plasminogen activator	MESH:D013197	25692(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	The effect of the anabolic steroid stanozolol on tissue_plasminogen_activator activity and plasmin inhibition in the rat .
17339469	0	staphopain_B	30,42	chemerin	91,99	staphopain B	chemerin	null	5919	Chemical	Gene	START_ENTITY|appos|activator activator|nmod|END_ENTITY	Staphylococcus_aureus-derived staphopain_B , a potent cysteine protease activator of plasma chemerin .
17339469	0	staphopain_B	30,42	chemerin	91,99	staphopain B	chemerin	null	5919	Chemical	Gene	START_ENTITY|appos|activator activator|nmod|END_ENTITY	Staphylococcus_aureus-derived staphopain_B , a potent cysteine protease activator of plasma chemerin .
16043642	0	statin	45,51	Kruppel-like_factor_2	0,21	statin	Kruppel-like factor 2	CHEBI:35664	10365	Chemical	Gene	effects|compound|START_ENTITY END_ENTITY|nmod|effects	Kruppel-like_factor_2 as a novel mediator of statin effects in endothelial cells .
20828695	0	statin	37,43	apolipoprotein_M	7,23	statin	apolipoprotein M	CHEBI:35664	55937	Chemical	Gene	administration|compound|START_ENTITY responses|nmod|administration responses|compound|END_ENTITY	Plasma apolipoprotein_M responses to statin and fibrate administration in type 2 diabetes_mellitus .
16285605	0	statin	104,110	familial_hypercholesterolemia	10,39	statin	familial hypercholesterolemia	CHEBI:35664	3949	Chemical	Gene	treatment|nmod|START_ENTITY LDL-apheresis|nmod|treatment secession|nmod|LDL-apheresis case|dep|secession case|nmod|END_ENTITY	A case of familial_hypercholesterolemia ; secession from LDL-apheresis by the drug treatment with potent statin and resin .
20435231	0	statin	48,54	familial_hypercholesterolemia	86,115	statin	familial hypercholesterolemia	CHEBI:35664	3949	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	Colesevelam added to combination therapy with a statin and ezetimibe in patients with familial_hypercholesterolemia : a 12-week , multicenter , randomized , double-blind , controlled trial .
20534948	0	statin	10,16	familial_hypercholesterolemia	64,93	statin	familial hypercholesterolemia	CHEBI:35664	3949	Chemical	Gene	treatment|compound|START_ENTITY Impact|nmod|treatment Impact|nmod|fate fate|nmod|END_ENTITY	Impact of statin treatment on the clinical fate of heterozygous familial_hypercholesterolemia .
21554872	0	statins	44,51	ABCA1	24,29	statins	ABCA1	null	313210(Tax:10116)	Chemical	Gene	mechanism|nmod|START_ENTITY mechanism|nmod|expression expression|compound|END_ENTITY	Regulation mechanism of ABCA1 expression by statins in hepatocytes .
11591701	0	statins	34,41	COX-2	14,19	statins	COX-2	null	4513	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|expression expression|compound|END_ENTITY	Modulation of COX-2 expression by statins in human aortic smooth muscle cells .
17317725	0	statins	34,41	COX-2	14,19	statins	COX-2	null	5743	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|expression expression|compound|END_ENTITY	Modulation of COX-2 expression by statins in human monocytic cells .
24128347	0	statins	15,22	HMG-CoA_reductase	99,116	statins	HMG-CoA reductase	null	3156	Chemical	Gene	effects|nmod|START_ENTITY effects|acl|expressing expressing|dobj|END_ENTITY	The effects of statins on the mevalonic_acid pathway in recombinant yeast strains expressing human HMG-CoA_reductase .
23612356	0	statins	73,80	MRP2	46,50	statins	MRP2	null	1244	Chemical	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Regulation of multidrug_resistance_protein_2 -LRB- MRP2 , ABCC2 -RRB- expression by statins : involvement of SREBP-mediated gene regulation .
21884024	0	statins	66,73	OATP1B1	12,19	statins	OATP1B1	null	10599	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of OATP1B1 and BCRP in pharmacokinetics and DDI of novel statins .
16635606	0	statins	10,17	PAR-1	30,35	statins	PAR-1	null	2149	Chemical	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	Effect of statins on platelet PAR-1 thrombin receptor in patients with the metabolic_syndrome -LRB- from the PAR-1 inhibition by statins -LSB- PARIS -RSB- study -RRB- .
24768901	0	statins	28,35	Perilipin-5	0,11	statins	Perilipin-5	null	66968(Tax:10090)	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Perilipin-5 is regulated by statins and controls triglyceride contents in the hepatocyte .
19291315	0	statins	11,18	albumin	51,58	statins	albumin	null	213	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of statins on the secretion of human serum albumin in cultured HepG2 cells .
22093199	1	statins	179,186	angiotensin-converting_enzyme	137,166	statins	angiotensin-converting enzyme	null	1636	Chemical	Gene	START_ENTITY|nsubj|impact impact|nmod|inhibitors inhibitors|amod|END_ENTITY	The impact of angiotensin-converting_enzyme inhibitors , statins , and b-blockers after coronary artery bypass graft surgery .
22237927	0	statins	21,28	cytochrome_P450_3A4	34,53	statins	cytochrome P450 3A4	null	1576	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Co-administration of statins with cytochrome_P450_3A4 inhibitors in a UK primary care population .
16740997	0	statins	34,41	endothelin-1	45,57	statins	endothelin-1	null	1906	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|amod|END_ENTITY	Differential effects of different statins on endothelin-1 gene expression and endothelial NOS phosphorylation in porcine aortic endothelial cells .
17763406	0	statins	122,129	matrix_metalloproteinase_1	46,72	statins	matrix metalloproteinase 1	null	4312	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|dep|effects	Protein isoprenylation regulates secretion of matrix_metalloproteinase_1 from rheumatoid synovial fibroblasts : effects of statins and farnesyl and geranylgeranyl transferase inhibitors .
10908155	0	statins	58,65	monocyte_chemotactic_protein-1	14,44	statins	monocyte chemotactic protein-1	null	20296(Tax:10090)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|synthesis synthesis|amod|END_ENTITY	Inhibition of monocyte_chemotactic_protein-1 synthesis by statins .
23612356	0	statins	73,80	multidrug_resistance_protein_2	14,44	statins	multidrug resistance protein 2	null	1244	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of multidrug_resistance_protein_2 -LRB- MRP2 , ABCC2 -RRB- expression by statins : involvement of SREBP-mediated gene regulation .
15879782	0	statins	14,21	prostate_specific_antigen	31,56	statins	prostate specific antigen	null	354	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	The effect of statins on serum prostate_specific_antigen levels in a cohort of airline pilots : a preliminary report .
24991787	0	statins	151,158	vascular_cell_adhesion_molecule_1	52,85	statins	vascular cell adhesion molecule 1	null	7412	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|END_ENTITY	Circulating monocyte_chemotactic_protein_1 -LRB- MCP-1 -RRB- , vascular_cell_adhesion_molecule_1 -LRB- VCAM-1 -RRB- and angiogenin in type 2 diabetic patients treated with statins in low doses .
16600175	0	staurosporine	41,54	Amyloid_precursor_protein	0,25	staurosporine	Amyloid precursor protein	MESH:D019311	351	Chemical	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	Amyloid_precursor_protein is involved in staurosporine induced glial differentiation of neural progenitor cells .
8660932	0	staurosporine	120,133	BCL-2	0,5	staurosporine	BCL-2	MESH:D019311	100774873	Chemical	Gene	induced|nmod|START_ENTITY acidification|acl|induced inhibits|dobj|acidification inhibits|nsubj|expression expression|amod|END_ENTITY	BCL-2 and MCL-1 expression in Chinese_hamster ovary cells inhibits intracellular acidification and apoptosis induced by staurosporine .
18983973	0	staurosporine	62,75	Bcl-2	93,98	staurosporine	Bcl-2	MESH:D019311	596	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	E-cadherin decreased human breast_cancer cells sensitivity to staurosporine by up-regulating Bcl-2 expression .
9438871	0	staurosporine	14,27	CDK2	37,41	staurosporine	CDK2	MESH:D019311	1017	Chemical	Gene	START_ENTITY|acl|bound bound|nmod|END_ENTITY	Structures of staurosporine bound to CDK2 and cAPK -- new tools for structure-based design of protein kinase inhibitors .
1571555	0	staurosporine	59,72	Granulocyte-macrophage_colony-stimulating_factor	0,48	staurosporine	Granulocyte-macrophage colony-stimulating factor	MESH:D019311	1437	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Granulocyte-macrophage_colony-stimulating_factor induces a staurosporine inhibitable tyrosine phosphorylation of unique neutrophil proteins .
9698090	0	staurosporine	10,23	NF-kappaB	48,57	staurosporine	NF-kappaB	MESH:D019311	4790	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of staurosporine on transcription factor NF-kappaB in human keratinocytes .
11006111	0	staurosporine	112,125	P-glycoprotein	20,34	staurosporine	P-glycoprotein	MESH:D019311	5243	Chemical	Gene	kinase|dobj|START_ENTITY kinase|nsubj|death death|acl|expressing expressing|nsubj|END_ENTITY	Equivalent death of P-glycoprotein expressing and nonexpressing cells induced by the protein kinase C inhibitor staurosporine .
20336234	0	staurosporine	50,63	Protein_kinase	0,14	staurosporine	Protein kinase	MESH:D019311	1022	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Protein_kinase inhibition of clinically important staurosporine analogues .
9334743	0	staurosporine	29,42	Protein_kinase	0,14	staurosporine	Protein kinase	MESH:D019311	1022	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Protein_kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2 .
10518116	0	staurosporine	24,37	bcl-2	128,133	staurosporine	bcl-2	MESH:D019311	596	Chemical	Gene	cells|amod|START_ENTITY effects|nmod|cells effects|dep|involvement involvement|nmod|proteins proteins|amod|END_ENTITY	Differential effects of staurosporine and retinoic_acid on the vulnerability of the SH-SY5Y neuroblastoma cells : involvement of bcl-2 and p53 proteins .
14563490	0	staurosporine	13,26	hepatocyte_growth_factor	30,54	staurosporine	hepatocyte growth factor	MESH:D019311	3082	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Induction by staurosporine of hepatocyte_growth_factor production in human skin fibroblasts independent of protein kinase inhibition .
1953675	0	staurosporine	13,26	insulin	71,78	staurosporine	insulin	MESH:D019311	3630	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|secretion secretion|compound|END_ENTITY	Influence of staurosporine on glucose-mediated and glucose-conditioned insulin secretion .
8129736	0	staurosporine	106,119	phospholipase_D	154,169	staurosporine	phospholipase D	MESH:D019311	2822	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	The zinc chelator 1,10-phenanthroline enhances the stimulatory effects of protein kinase C activators and staurosporine , but not sphingosine and H2O2 , on phospholipase_D activity in NIH 3T3 fibroblasts .
2140592	0	staurosporine	95,108	protein_kinase_C	119,135	staurosporine	protein kinase C	MESH:D019311	112476	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Inhibition of TPA-induced monocytic differentiation in THP-1 human monocytic leukemic cells by staurosporine , a potent protein_kinase_C inhibitor .
16225760	0	staurosporine	103,116	protein_kinase_C_alpha	10,32	staurosporine	protein kinase C alpha	MESH:D019311	5578	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Effect Effect|nmod|END_ENTITY	Effect of protein_kinase_C_alpha , caspase-3 , and survivin on apoptosis of oral_cancer cells induced by staurosporine .
17352834	0	stavudine	59,68	CD4	163,166	stavudine	CD4	MESH:D018119	920	Chemical	Gene	therapy|amod|START_ENTITY therapy|nmod|patients patients|nmod|END_ENTITY	Safety and efficacy of a generic fixed-dose combination of stavudine , lamivudine and nevirapine antiretroviral therapy between HIV-infected patients with baseline CD4 < 50 versus CD4 > or = 50 cells/mm3 .
25529423	0	stearic_acid	37,49	Milk	0,4	stearic acid	Milk	MESH:C031183	100532204	Chemical	Gene	responses|nmod|START_ENTITY responses|compound|END_ENTITY	Milk production responses to dietary stearic_acid vary by production level in dairy cattle .
22966071	0	stearic_acid	79,91	Sterol_regulatory_element-binding_protein-1c	0,44	stearic acid	Sterol regulatory element-binding protein-1c	MESH:C031183	20787(Tax:10090)	Chemical	Gene	increase|nmod|START_ENTITY increase|amod|END_ENTITY	Sterol_regulatory_element-binding_protein-1c mediates increase of postprandial stearic_acid , a potential target for improving insulin resistance , in hyperlipidemia .
24342689	0	stearic_acid	14,26	milk	65,69	stearic acid	milk	MESH:C031183	100532204	Chemical	Gene	increased|advcl|START_ENTITY increased|dobj|yield yield|nmod|fat fat|nmod:npmod|END_ENTITY	Compared with stearic_acid , palmitic_acid increased the yield of milk fat and improved feed efficiency across production level of cows .
22848162	0	stearic_acid-octaarginine	40,65	insulin	93,100	stearic acid-octaarginine	insulin	null	3630	Chemical	Gene	START_ENTITY|nmod|administration administration|nmod|END_ENTITY	Solid lipid nanoparticles modified with stearic_acid-octaarginine for oral administration of insulin .
23269653	5	stearoyl-CoA	1044,1056	Fasn	1093,1097	stearoyl-CoA	Fasn	MESH:C017725	50671(Tax:10116)	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	In the liver , lipogenesis was promoted as illustrated by an increase in stearoyl-CoA desaturase and fatty_acid synthase -LRB- Fasn -RRB- together with a decrease in PPAR_gamma , delta and PPAR_gamma coactivator 1 alpha -LRB- PGC1_alpha -RRB- expression .
24836198	0	stearoyl-CoA	26,38	SCD-1	51,56	stearoyl-CoA	SCD-1	MESH:C017725	246074(Tax:10116)	Chemical	Gene	desaturase|amod|START_ENTITY desaturase|appos|END_ENTITY	Oleic_acid synthesized by stearoyl-CoA desaturase -LRB- SCD-1 -RRB- in the lateral periventricular zone of the developing rat brain mediates neuronal growth , migration and the arrangement of prospective synapses .
23265904	0	stearoyl-CoA	42,54	SCD1	67,71	stearoyl-CoA	SCD1	MESH:C017725	246074(Tax:10116)	Chemical	Gene	desaturase|amod|START_ENTITY desaturase|appos|END_ENTITY	Discovery of liver-targeted inhibitors of stearoyl-CoA desaturase -LRB- SCD1 -RRB- .
17391062	0	stearoyl-CoA	26,38	scd1	61,65	stearoyl-CoA	scd1	MESH:C017725	20249(Tax:10090)	Chemical	Gene	mouse|amod|START_ENTITY mouse|dep|END_ENTITY	Obesity resistance of the stearoyl-CoA desaturase-deficient -LRB- scd1 - / - -RRB- mouse results from disruption of the epidermal lipid barrier and adaptive thermoregulation .
23019225	0	stearoyl_CoA	17,29	FGFR3	0,5	stearoyl CoA	FGFR3	MESH:C017725	2261	Chemical	Gene	activity|amod|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	FGFR3 stimulates stearoyl_CoA desaturase 1 activity to promote bladder_tumor growth .
15605704	0	stearoyl_CoA	93,105	SCD	118,121	stearoyl CoA	SCD	MESH:C017725	280924(Tax:9913)	Chemical	Gene	desaturase|compound|START_ENTITY desaturase|appos|END_ENTITY	A mathematical model for mammary fatty_acid synthesis and triglyceride assembly : the role of stearoyl_CoA desaturase -LRB- SCD -RRB- .
20691778	0	stearoyl_CoA	45,57	SCD	70,73	stearoyl CoA	SCD	MESH:C017725	102401664	Chemical	Gene	desaturase|compound|START_ENTITY desaturase|appos|END_ENTITY	Sequence analysis and genetic variability of stearoyl_CoA desaturase -LRB- SCD -RRB- gene in the Italian Mediterranean river_buffalo .
21786221	0	stemofoline	63,74	P-glycoprotein	45,59	stemofoline	P-glycoprotein	MESH:C430220	5243	Chemical	Gene	mechanism|nmod|START_ENTITY mechanism|nmod|END_ENTITY	Biochemical mechanism of modulation of human P-glycoprotein by stemofoline .
23314349	0	stemonamide	8,19	Pim	52,55	stemonamide	Pim	MESH:C434309	5292	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	T-18 , a stemonamide synthetic intermediate inhibits Pim kinase activity and induces cell apoptosis , acting as a potent anticancer drug .
22344519	0	sterigmatocystin	11,27	TNF-a	31,36	sterigmatocystin	TNF-a	MESH:D013241	21926(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of sterigmatocystin on TNF-a , IL-6 and IL-12 expression in murine peripheral blood mononuclear cells and peritoneal macrophages in vivo .
12561545	0	sterigmatocystin	12,28	interleukin-2	32,45	sterigmatocystin	interleukin-2	MESH:D013241	3558	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|compound|END_ENTITY	-LSB- Effects of sterigmatocystin on interleukin-2 secretion of human peripheral blood mononuclear cells in vitro -RSB- .
10325614	0	sterigmatocystin	12,28	p21	36,39	sterigmatocystin	p21	MESH:D013241	644914	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effects of sterigmatocystin on ras p21 expression and ultrastructure of human lung fibroblasts in vitro -RSB- .
2109953	0	steroid	10,17	21-hydroxylase	18,32	steroid	21-hydroxylase	CHEBI:35341	13079(Tax:10090)	Chemical	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	The swine steroid 21-hydroxylase gene -LRB- CYP21 -RRB- : cloning and mapping within the swine leucocyte antigen complex .
10863799	0	steroid	17,24	5_alpha-reductase	25,42	steroid	5 alpha-reductase	CHEBI:35341	6715	Chemical	Gene	START_ENTITY|dobj|inhibitors inhibitors|amod|END_ENTITY	New nonsteroidal steroid 5_alpha-reductase inhibitors .
12434569	0	steroid	48,55	5_alpha-reductase	0,17	steroid	5 alpha-reductase	CHEBI:35341	6715	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	5_alpha-reductase inhibition by a new synthetic steroid -LRB- PM-9 -RRB- in cultures of Penicillium crustosum .
1309834	0	steroid	61,68	5_alpha-reductase	69,86	steroid	5 alpha-reductase	CHEBI:35341	6715	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Hair growth effects of oral administration of finasteride , a steroid 5_alpha-reductase inhibitor , alone and in combination with topical minoxidil in the balding stumptail macaque .
1723383	1	steroid	61,68	5_alpha-reductase	69,86	steroid	5 alpha-reductase	CHEBI:35341	6715	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	The potential medical uses of steroid 5_alpha-reductase inhibitors .
6333981	0	steroid	74,81	5_alpha-reductase	10,27	steroid	5 alpha-reductase	CHEBI:35341	6715	Chemical	Gene	substrate|amod|START_ENTITY affinity|nmod|substrate END_ENTITY|nmod|affinity	Deficient 5_alpha-reductase due to mutant enzyme with reduced affinity to steroid substrate .
6938516	0	steroid	13,20	5_alpha-reductase	21,38	steroid	5 alpha-reductase	CHEBI:35341	6715	Chemical	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Variation in steroid 5_alpha-reductase activity in cloned human skin fibroblasts .
7577710	0	steroid	16,23	5_alpha-reductase	24,41	steroid	5 alpha-reductase	CHEBI:35341	6715	Chemical	Gene	isoforms|amod|START_ENTITY isoforms|amod|END_ENTITY	Human prostatic steroid 5_alpha-reductase isoforms -- a comparative study of selective inhibitors .
7688765	0	steroid	36,43	5_alpha-reductase	44,61	steroid	5 alpha-reductase	CHEBI:35341	6715	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Tissue distribution and ontogeny of steroid 5_alpha-reductase isozyme expression .
7796940	0	steroid	45,52	5_alpha-reductase	53,70	steroid	5 alpha-reductase	CHEBI:35341	6715	Chemical	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Activin and inhibin have opposite effects on steroid 5_alpha-reductase activity in genital skin fibroblasts .
8039530	0	steroid	93,100	5_alpha-reductase	101,118	steroid	5 alpha-reductase	CHEBI:35341	6715	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Plasma concentrations and effect on testosterone metabolism after single doses of MK-0434 , a steroid 5_alpha-reductase inhibitor , in healthy subjects .
8143914	0	steroid	74,81	5_alpha-reductase	82,99	steroid	5 alpha-reductase	CHEBI:35341	6715	Chemical	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Effects of transforming_growth_factor_beta and epidermal growth factor on steroid 5_alpha-reductase activity in genital skin fibroblasts .
8451911	0	steroid	13,20	5_alpha-reductase	33,50	steroid	5 alpha-reductase	CHEBI:35341	6715	Chemical	Gene	hormones|amod|START_ENTITY Influence|nmod|hormones Influence|nmod|activity activity|amod|END_ENTITY	Influence of steroid hormones on 5_alpha-reductase activity in female and male genital skin fibroblasts in culture .
9341922	0	steroid	38,45	5_alpha-reductase	46,63	steroid	5 alpha-reductase	CHEBI:35341	6715	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	19-nor-10-azasteroids , a new class of steroid 5_alpha-reductase inhibitors .
9492851	0	steroid	51,58	5_alpha-reductase	59,76	steroid	5 alpha-reductase	CHEBI:35341	6715	Chemical	Gene	START_ENTITY|dobj|isozymes isozymes|amod|END_ENTITY	Identification and partial characterization of two steroid 5_alpha-reductase isozymes in the canine prostate .
10386934	0	steroid	61,68	5alpha-reductase	69,85	steroid	5alpha-reductase	CHEBI:35341	6715	Chemical	Gene	activities|amod|START_ENTITY activities|nummod|END_ENTITY	Dual-acting agents with alpha1-adrenoceptor antagonistic and steroid 5alpha-reductase inhibitory activities .
10416833	0	steroid	15,22	5alpha-reductase	23,39	steroid	5alpha-reductase	CHEBI:35341	6715	Chemical	Gene	START_ENTITY|dobj|expression expression|amod|END_ENTITY	Differences in steroid 5alpha-reductase iso-enzymes expression between normal and pathological human prostate tissue .
10906740	0	steroid	69,76	5alpha-reductase	77,93	steroid	5alpha-reductase	CHEBI:35341	6715	Chemical	Gene	type|amod|START_ENTITY type|amod|END_ENTITY	Partial sequencing and tissue distribution of the canine isoforms of steroid 5alpha-reductase type I and type II .
11182141	0	steroid	23,30	5alpha-reductase	31,47	steroid	5alpha-reductase	CHEBI:35341	6715	Chemical	Gene	START_ENTITY|dobj|activity activity|amod|END_ENTITY	In vitro modulation of steroid 5alpha-reductase activity by phospholipases in epithelium and stroma of human benign_prostatic_hyperplasia .
11279132	0	steroid	113,120	5alpha-reductase	121,137	steroid	5alpha-reductase	CHEBI:35341	6715	Chemical	Gene	1-4-azasteroids|amod|START_ENTITY 1-4-azasteroids|amod|END_ENTITY	Linear relationships between the ligand binding energy and the activation energy of time-dependent inhibition of steroid 5alpha-reductase by delta 1-4-azasteroids .
11948017	0	steroid	14,21	5alpha-reductase	22,38	steroid	5alpha-reductase	CHEBI:35341	6715	Chemical	Gene	START_ENTITY|dobj|genes genes|amod|END_ENTITY	Evidence that steroid 5alpha-reductase isozyme genes are differentially methylated in human lymphocytes .
12488348	0	steroid	51,58	5alpha-reductase	71,87	steroid	5alpha-reductase	CHEBI:35341	6715	Chemical	Gene	metabolism|compound|START_ENTITY similarity|nmod|metabolism evidence|nmod|similarity evidence|dep|activity activity|amod|END_ENTITY	New evidence of similarity between human and plant steroid metabolism : 5alpha-reductase activity in Solanum malacoxylon .
12628690	0	steroid	18,25	5alpha-reductase	54,70	steroid	5alpha-reductase	CHEBI:35341	6715	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|present present|amod|END_ENTITY	Effect of a novel steroid -LRB- PM-9 -RRB- on the inhibition of 5alpha-reductase present in Penicillium crustosum broths .
12670724	0	steroid	37,44	5alpha-reductase	45,61	steroid	5alpha-reductase	CHEBI:35341	6715	Chemical	Gene	type|amod|START_ENTITY type|amod|END_ENTITY	Analysis of genetic polymorphisms of steroid 5alpha-reductase type 1 and 2 genes in Korean men with androgenetic_alopecia .
12930680	0	steroid	32,39	5alpha-reductase	40,56	steroid	5alpha-reductase	CHEBI:35341	6715	Chemical	Gene	isoenzymes|amod|START_ENTITY isoenzymes|amod|END_ENTITY	-LSB- Expression and significance of steroid 5alpha-reductase isoenzymes in benign hyperplastic prostate tissues -RSB- .
14592534	0	steroid	31,38	5alpha-reductase	39,55	steroid	5alpha-reductase	CHEBI:35341	6715	Chemical	Gene	isozymes|amod|START_ENTITY isozymes|amod|END_ENTITY	Quantitation of mRNA levels of steroid 5alpha-reductase isozymes : a novel method that combines quantitative RT-PCR and capillary electrophoresis .
15020105	0	steroid	31,38	5alpha-reductase	39,55	steroid	5alpha-reductase	CHEBI:35341	6715	Chemical	Gene	START_ENTITY|dobj|isozymes isozymes|amod|END_ENTITY	Quantitation of mRNA levels of steroid 5alpha-reductase isozymes in the rat brain by `` one-step '' RT-PCR and capillary electrophoresis .
15770495	0	steroid	72,79	5alpha-reductase	80,96	steroid	5alpha-reductase	CHEBI:35341	6715	Chemical	Gene	deficiency_type_2|amod|START_ENTITY deficiency_type_2|amod|END_ENTITY	New mutations , hotspots , and founder effects in Brazilian patients with steroid 5alpha-reductase deficiency_type_2 .
16030154	0	steroid	170,177	5alpha-reductase	59,75	steroid	5alpha-reductase	CHEBI:35341	6715	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|acl|combined combined|nmod|inhibitor inhibitor|amod|END_ENTITY	Effects of testosterone and levonorgestrel combined with a 5alpha-reductase inhibitor or gonadotropin-releasing_hormone antagonist on spermatogenesis and intratesticular steroid levels in normal men .
17417080	0	steroid	113,120	5alpha-reductase	31,47	steroid	5alpha-reductase	CHEBI:35341	6715	Chemical	Gene	profiles|amod|START_ENTITY influence|nmod|profiles determination|nmod|influence analysis|dep|determination analysis|nmod|finasteride finasteride|amod|END_ENTITY	Doping-control analysis of the 5alpha-reductase inhibitor finasteride : determination of its influence on urinary steroid profiles and detection of its major urinary metabolite .
17686629	0	steroid	34,41	5alpha-reductase	89,105	steroid	5alpha-reductase	CHEBI:35341	6715	Chemical	Gene	substitute|amod|START_ENTITY skeleton|nmod|substitute skeleton|dep|inhibitors inhibitors|nmod|1 1|nummod|END_ENTITY	3,3-diphenylpentane skeleton as a steroid skeleton substitute : novel inhibitors of human 5alpha-reductase 1 .
20519274	0	steroid	27,34	5alpha-reductase	35,51	steroid	5alpha-reductase	CHEBI:35341	6715	Chemical	Gene	isozymes|amod|START_ENTITY isozymes|amod|END_ENTITY	Differential expression of steroid 5alpha-reductase isozymes and association with disease severity and angiogenic genes predict their biological role in prostate_cancer .
9679931	0	steroid	41,48	5alpha-reductase	49,65	steroid	5alpha-reductase	CHEBI:35341	6715	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Localization by in situ hybridization of steroid 5alpha-reductase isozyme gene expression in the human prostate and preputial skin .
6267148	0	steroid	16,23	ACTH	44,48	steroid	ACTH	CHEBI:35341	5443	Chemical	Gene	START_ENTITY|nmod|infusions infusions|compound|END_ENTITY	Multiple plasma steroid responses to graded ACTH infusions in patients with primary_aldosteronism .
12710999	0	steroid	40,47	AR	116,118	steroid	AR	CHEBI:35341	280675(Tax:9913)	Chemical	Gene	action|amod|START_ENTITY target|nmod|action tract|nmod|target tract|dep|quantification quantification|nmod|expression expression|appos|END_ENTITY	The gastrointestinal tract as target of steroid hormone action : quantification of steroid receptor mRNA expression -LRB- AR , ERalpha , ERbeta and PR -RRB- in 10 bovine gastrointestinal tract compartments by kinetic RT-PCR .
12710999	0	steroid	82,89	AR	116,118	steroid	AR	CHEBI:35341	280675(Tax:9913)	Chemical	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	The gastrointestinal tract as target of steroid hormone action : quantification of steroid receptor mRNA expression -LRB- AR , ERalpha , ERbeta and PR -RRB- in 10 bovine gastrointestinal tract compartments by kinetic RT-PCR .
20127713	1	steroid	247,254	AR	183,185	steroid	AR	CHEBI:35341	367	Chemical	Gene	receptor|amod|START_ENTITY belonging|nmod|receptor factor|acl|belonging factor|nsubj|androgen_receptor androgen_receptor|appos|END_ENTITY	The androgen_receptor -LRB- AR -RRB- is a ligand-dependent transcription factor belonging to the steroid hormone receptor superfamily .
8463279	0	steroid	57,64	Ad4BP	0,5	steroid	Ad4BP	CHEBI:35341	26423(Tax:10090)	Chemical	Gene	superfamily|amod|START_ENTITY member|nmod|superfamily member|nsubj|END_ENTITY	Ad4BP regulating steroidogenic P-450 gene is a member of steroid hormone receptor superfamily .
8844777	0	steroid	26,33	Adrenomedullin	0,14	steroid	Adrenomedullin	CHEBI:35341	25026(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|stimulates stimulates|compound|END_ENTITY	Adrenomedullin stimulates steroid secretion by the isolated perfused rat adrenal gland in situ : comparison with calcitonin_gene-related_peptide effects .
2447390	0	steroid	107,114	Androgen_receptor	0,17	steroid	Androgen receptor	CHEBI:35341	367	Chemical	Gene	autoradiography|amod|START_ENTITY method|nmod|autoradiography using|dobj|method demonstration|acl|using localization|dep|demonstration localization|amod|END_ENTITY	Androgen_receptor localization in the human prostate : demonstration of heterogeneity using a new method of steroid receptor autoradiography .
3879032	0	steroid	87,94	Androgen_receptor	0,17	steroid	Androgen receptor	CHEBI:35341	367	Chemical	Gene	environment|amod|START_ENTITY END_ENTITY|nmod|environment	Androgen_receptor content in cytosol from non-tumoral human kidney and its relation to steroid hormone environment .
1457080	0	steroid	42,49	Angiotensin_II	0,14	steroid	Angiotensin II	CHEBI:35341	183	Chemical	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Angiotensin_II regulates cytochrome P-450 steroid hydroxylase enzyme expression in human adrenal glomerulosa cells .
23221601	0	steroid	49,56	Angiotensin_II	0,14	steroid	Angiotensin II	CHEBI:35341	183	Chemical	Gene	production|amod|START_ENTITY metabolism|nmod|production metabolism|nsubj|END_ENTITY	Angiotensin_II and III metabolism and effects on steroid production in the HAC15 human adrenocortical cell line .
16483614	0	steroid	74,81	Aquaporin-2	0,11	steroid	Aquaporin-2	CHEBI:35341	359	Chemical	Gene	START_ENTITY|nsubj|expression expression|amod|END_ENTITY	Aquaporin-2 expression in human endometrium correlates with serum ovarian steroid hormones .
2968429	0	steroid	50,57	C21	38,41	steroid	C21	CHEBI:35341	79718	Chemical	Gene	START_ENTITY|nsubj|Changes Changes|nmod|levels levels|nmod|END_ENTITY	-LSB- Changes in maternal plasma levels of C21 and C19 steroid hormones during pregnancy -RSB- .
16388888	0	steroid	47,54	CD_38	14,19	steroid	CD 38	CHEBI:35341	25668(Tax:10116)	Chemical	Gene	hormones|amod|START_ENTITY Regulation|nmod|hormones Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of CD_38 expression and function by steroid hormones in myometrium .
25012481	0	steroid	25,32	COMT	53,57	steroid	COMT	CHEBI:35341	1312	Chemical	Gene	START_ENTITY|dobj|genes genes|appos|END_ENTITY	Association study of two steroid biosynthesis genes -LRB- COMT and CYP17 -RRB- with Alzheimer 's _ disease in the Italian population .
2569487	0	steroid	13,20	CRH	77,80	steroid	CRH	CHEBI:35341	81648(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Differential steroid hormone and neural influences on peptide mRNA levels in CRH cells of the paraventricular nucleus : a hybridization histochemical study in the rat .
9147642	0	steroid	19,26	CYP11a	42,48	steroid	CYP11a	CHEBI:35341	1583	Chemical	Gene	gene|amod|START_ENTITY Association|nmod|gene END_ENTITY|nsubj|Association	Association of the steroid synthesis gene CYP11a with polycystic_ovary_syndrome and hyperandrogenism .
10460013	0	steroid	118,125	CYP17	214,219	steroid	CYP17	CHEBI:35341	1586	Chemical	Gene	pattern|amod|START_ENTITY compatible|nsubj|pattern showing|xcomp|compatible presenting|advcl|showing patient|acl|presenting patient|dep|deficiency deficiency|advmod|but but|nmod|mutations mutations|compound|END_ENTITY	A male patient presenting with major clinical symptoms of glucocorticoid_deficiency and skeletal_dysplasia , showing a steroid pattern compatible with 17alpha-hydroxylase/17 ,20 - lyase deficiency , but without obvious CYP17 gene mutations .
12530262	0	steroid	25,32	CYP17	67,72	steroid	CYP17	CHEBI:35341	1586	Chemical	Gene	17|amod|START_ENTITY polymorphism|nmod|17 polymorphism|dep|lyase lyase|appos|END_ENTITY	-LSB- Genetic polymorphism of steroid 17 alpha-hydroxylase/17 ,20 - lyase -LRB- CYP17 -RRB- and hyperinsulinemia in endometrial_carcinoma -RSB- .
1329985	0	steroid	52,59	CYP17	101,106	steroid	CYP17	CHEBI:35341	25146(Tax:10116)	Chemical	Gene	P-450|amod|START_ENTITY P-450|appos|END_ENTITY	Cyclic_AMP regulates expression of the rat gene for steroid 17 alpha-hydroxylase/C17 -20 lyase P-450 -LRB- CYP17 -RRB- in rat Leydig cells .
15477877	0	steroid	10,17	CYP17	54,59	steroid	CYP17	CHEBI:35341	1586	Chemical	Gene	levels|amod|START_ENTITY levels|nmod|END_ENTITY	Serum sex steroid hormone levels and polymorphisms of CYP17 and SRD5A2 : implication for prostate_cancer risk .
16426683	0	steroid	28,35	CYP17	0,5	steroid	CYP17	CHEBI:35341	1586	Chemical	Gene	hydroxylases|amod|START_ENTITY hydroxylases|amod|END_ENTITY	CYP17 - and CYP11B-dependent steroid hydroxylases as drug development targets .
17765230	0	steroid	48,55	CYP17	22,27	steroid	CYP17	CHEBI:35341	1586	Chemical	Gene	START_ENTITY|nsubj|polymorphism polymorphism|nmod|gene gene|compound|END_ENTITY	A polymorphism of the CYP17 gene related to sex steroid metabolism is associated with female-to-male but not male-to-female transsexualism .
21871953	0	steroid	37,44	CYP17	56,61	steroid	CYP17	CHEBI:35341	1586	Chemical	Gene	START_ENTITY|dep|secretion secretion|nummod|END_ENTITY	Congener-specific action of PBDEs on steroid secretion , CYP17 , 17b-HSD and CYP19 activity and protein expression in porcine ovarian follicles .
21948762	0	steroid	25,32	CYP17	70,75	steroid	CYP17	CHEBI:35341	1586	Chemical	Gene	START_ENTITY|nmod|polymorphisms polymorphisms|compound|END_ENTITY	Association of serum sex steroid levels and bone_mineral_density with CYP17 and CYP19 gene polymorphisms in postmenopausal women in Turkey .
22817457	0	steroid	100,107	CYP17	72,77	steroid	CYP17	CHEBI:35341	1586	Chemical	Gene	biosynthesis|amod|START_ENTITY involved|nmod|biosynthesis involved|nsubj|Mechanism Mechanism|nmod|interactions interactions|nmod|END_ENTITY	Mechanism of intermolecular interactions of microsomal cytochrome P450s CYP17 and CYP21 involved in steroid hormone biosynthesis .
24810611	0	steroid	162,169	CYP17	235,240	steroid	CYP17	CHEBI:35341	1586	Chemical	Gene	START_ENTITY|dobj|secretion secretion|nmod|enzymes enzymes|acl|involved involved|nmod|steroidogenesis steroidogenesis|dep|END_ENTITY	Effects of individual polychlorinated naphthalene -LRB- PCN -RRB- components of Halowax 1051 and two defined , artificial PCN mixtures on AHR and CYP1A1 protein expression , steroid secretion and expression of enzymes involved in steroidogenesis -LRB- CYP17 , 17b-HSD and CYP19 -RRB- in porcine ovarian follicles .
20132843	0	steroid	14,21	CYP21	81,86	steroid	CYP21	CHEBI:35341	1589	Chemical	Gene	biotransformation|amod|START_ENTITY Challenges|nmod|biotransformation monooxygenase|nsubj|Challenges monooxygenase|dep|using using|nsubj|END_ENTITY	Challenges of steroid biotransformation with human cytochrome_P450 monooxygenase CYP21 using resting cells of recombinant Schizosaccharomyces_pombe .
2109953	0	steroid	10,17	CYP21	39,44	steroid	CYP21	CHEBI:35341	403337(Tax:9823)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The swine steroid 21-hydroxylase gene -LRB- CYP21 -RRB- : cloning and mapping within the swine leucocyte antigen complex .
17204458	0	steroid	66,73	CYP3A4	107,113	steroid	CYP3A4	CHEBI:35341	1576	Chemical	Gene	START_ENTITY|nmod|site site|nmod|END_ENTITY	Theoretical calculation of triazolam hydroxylation and endogenous steroid inhibition in the active site of CYP3A4 .
20849814	0	steroid	136,143	CYP3A4	39,45	steroid	CYP3A4	CHEBI:35341	1576	Chemical	Gene	metabolism|amod|START_ENTITY patients|nmod|metabolism identified|nmod|patients mutations|acl|identified caused|nmod|mutations caused|nsubj|Reduction Reduction|nmod|drug drug|acl|metabolizing metabolizing|dobj|activities activities|nummod|END_ENTITY	Reduction in hepatic drug metabolizing CYP3A4 activities caused by P450 oxidoreductase mutations identified in patients with disordered steroid metabolism .
12239117	0	steroid	78,85	Calcitonin	0,10	steroid	Calcitonin	CHEBI:35341	24241(Tax:10116)	Chemical	Gene	hormones|amod|START_ENTITY regulated|nmod|hormones regulated|nsubjpass|expression expression|compound|END_ENTITY	Calcitonin expression in rat anterior pituitary gland is regulated by ovarian steroid hormones .
17644521	0	steroid	56,63	Corticosteroid-binding_globulin	0,31	steroid	Corticosteroid-binding globulin	CHEBI:35341	299270(Tax:10116)	Chemical	Gene	transport|amod|START_ENTITY basis|nmod|transport END_ENTITY|appos|basis	Corticosteroid-binding_globulin , a structural basis for steroid transport and proteinase-triggered release .
9348209	0	steroid	47,54	Corticotropin-releasing_hormone	0,31	steroid	Corticotropin-releasing hormone	CHEBI:35341	1392	Chemical	Gene	biosynthesis|amod|START_ENTITY inhibits|dobj|biosynthesis inhibits|nsubj|END_ENTITY	Corticotropin-releasing_hormone -LRB- CRH -RRB- inhibits steroid biosynthesis by cultured human granulosa-lutein cells in a CRH and interleukin-1 receptor-mediated fashion .
21195129	0	steroid	14,21	Cyp11a1	46,53	steroid	Cyp11a1	CHEBI:35341	1583	Chemical	Gene	production|amod|START_ENTITY Regulation|nmod|production Regulation|dep|analysis analysis|nmod|promoter promoter|amod|END_ENTITY	Regulation of steroid production : analysis of Cyp11a1 promoter .
8188299	0	steroid	12,19	Cyp2a-4	47,54	steroid	Cyp2a-4	CHEBI:35341	13086(Tax:10090)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Lack of the steroid 15 alpha-hydroxylase gene -LRB- Cyp2a-4 -RRB- in wild mouse_strain Mus spretus : rapid evolution of the P450 gene superfamily .
9408084	0	steroid	43,50	Cyp2a-4	77,84	steroid	Cyp2a-4	CHEBI:35341	13086(Tax:10090)	Chemical	Gene	15alpha-hydroxylase|amod|START_ENTITY gene|amod|15alpha-hydroxylase gene|appos|END_ENTITY	Transcriptional regulation by HNF-4 of the steroid 15alpha-hydroxylase P450 -LRB- Cyp2a-4 -RRB- gene in mouse liver .
18056973	0	steroid	35,42	DAF-12	28,34	steroid	DAF-12	CHEBI:35341	181263(Tax:6239)	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|END_ENTITY	Sex-specific effects of the DAF-12 steroid receptor on aging in Caenorhabditis_elegans .
16960027	0	steroid	173,180	DHEAS	0,5	steroid	DHEAS	CHEBI:35341	6822	Chemical	Gene	START_ENTITY|nsubj|levels levels|compound|END_ENTITY	DHEAS levels and mortality in disabled older women : the Women 's Health and Aging Study I. BACKGROUND : Dehydroepiandrosterone_sulfate -LRB- DHEAS -RRB- is an endogenously produced sex steroid that has been hypothesized to have anti-aging effects .
15199138	0	steroid	19,26	Dyrk1A	0,6	steroid	Dyrk1A	CHEBI:35341	1859	Chemical	Gene	START_ENTITY|nsubj|potentiates potentiates|amod|END_ENTITY	Dyrk1A potentiates steroid hormone-induced transcription via the chromatin remodeling factor Arip4 .
15222754	0	steroid	22,29	E2F-1	91,96	steroid	E2F-1	CHEBI:35341	399489(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY Modulation|nmod|receptors Modulation|nmod|END_ENTITY	Modulation of nuclear steroid receptors by ursodeoxycholic_acid inhibits TGF-beta1-induced E2F-1 / p53-mediated apoptosis of rat hepatocytes .
17649814	0	steroid	19,26	ERalpha	38,45	steroid	ERalpha	CHEBI:35341	2099	Chemical	Gene	START_ENTITY|dobj|receptors receptors|dep|END_ENTITY	Expression of HPV , steroid receptors -LRB- ERalpha , ERbeta , PR-A and PR-B -RRB- and inhibin/activin subunits -LRB- alpha , betaA and betaB -RRB- in adenosquamous endometrial_carcinoma .
22509838	0	steroid	90,97	ESR1	116,120	steroid	ESR1	CHEBI:35341	2099	Chemical	Gene	START_ENTITY|dobj|receptors receptors|dep|END_ENTITY	Selected variants of the steroid-5-alpha-reductase isoforms SRD5A1 and SRD5A2 and the sex steroid hormone receptors ESR1 , ESR2 and PGR : no association with female pattern hair loss identified .
2119298	0	steroid	22,29	Endothelin	0,10	steroid	Endothelin	CHEBI:35341	1906	Chemical	Gene	START_ENTITY|nsubj|stimulates stimulates|compound|END_ENTITY	Endothelin stimulates steroid secretion by frog adrenal gland in vitro : evidence for the involvement of prostaglandins and extracellular calcium in the mechanism of actin of endothelin .
2439507	0	steroid	34,41	Epidermal_growth_factor	0,23	steroid	Epidermal growth factor	CHEBI:35341	13645(Tax:10090)	Chemical	Gene	biosynthesis|amod|START_ENTITY activates|dobj|biosynthesis activates|nsubj|END_ENTITY	Epidermal_growth_factor activates steroid biosynthesis in cultured Leydig_tumor cells without affecting the levels of cAMP and potentiates the activation of steroid biosynthesis by choriogonadotropin and cAMP .
9419783	0	steroid	153,160	Epidermal_growth_factor	0,23	steroid	Epidermal growth factor	CHEBI:35341	101026665	Chemical	Gene	treatment|amod|START_ENTITY oviduct|nmod|treatment oviduct|nsubj|END_ENTITY	Epidermal_growth_factor , transforming_growth_factor-alpha , and epidermal_growth_factor_receptor localization in the baboon -LRB- Papio_anubis -RRB- oviduct during steroid treatment and the menstrual cycle .
8551055	0	steroid	72,79	Epidermal_growth_factor_receptor	0,32	steroid	Epidermal growth factor receptor	CHEBI:35341	1956	Chemical	Gene	receptors|amod|START_ENTITY END_ENTITY|nmod|receptors	Epidermal_growth_factor_receptor in human breast_cancer comparison with steroid receptors and other prognostic factors .
24040820	0	steroid	56,63	FKBP5	47,52	steroid	FKBP5	CHEBI:35341	2289	Chemical	Gene	receptors|amod|START_ENTITY END_ENTITY|nmod|receptors	The role of FKBP5 in mood disorders : action of FKBP5 on steroid hormone receptors leads to questions about its evolutionary importance .
26705148	0	steroid	73,80	FOXD3	103,108	steroid	FOXD3	D013256	27022	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	In silico , in vitro and in vivo analysis identifies a potential role for steroid hormone regulation of FOXD3 in endometriosis-associated genes .
1545809	0	steroid	94,101	FTZ-F1	70,76	steroid	FTZ-F1	CHEBI:35341	26423(Tax:10090)	Chemical	Gene	superfamily|amod|START_ENTITY member|nmod|superfamily END_ENTITY|appos|member	Embryonal_long_terminal_repeat-binding_protein is a murine homolog of FTZ-F1 , a member of the steroid receptor superfamily .
1709303	0	steroid	10,17	FTZ-F1	0,6	steroid	FTZ-F1	CHEBI:35341	40045(Tax:7227)	Chemical	Gene	protein|amod|START_ENTITY END_ENTITY|appos|protein	FTZ-F1 , a steroid hormone receptor-like protein implicated in the activation of fushi_tarazu .
8096644	0	steroid	28,35	FTZ-F1	21,27	steroid	FTZ-F1	CHEBI:35341	40045(Tax:7227)	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	Potential role for a FTZ-F1 steroid receptor superfamily member in the control of Drosophila metamorphosis .
8413309	0	steroid	76,83	FTZ-F1	30,36	steroid	FTZ-F1	CHEBI:35341	26423(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY regulator|nmod|expression encodes|dobj|regulator gene|acl:relcl|encodes gene|compound|END_ENTITY	Characterization of the mouse FTZ-F1 gene , which encodes a key regulator of steroid hydroxylase gene expression .
9355109	0	steroid	8,15	GAP-43	56,62	steroid	GAP-43	CHEBI:35341	2596	Chemical	Gene	START_ENTITY|dobj|regulation regulation|nmod|expression expression|compound|END_ENTITY	Gonadal steroid regulation of growth-associated_protein GAP-43 mRNA expression in axotomized hamster facial motor neurons .
2222438	0	steroid	34,41	GD3_synthase	14,26	steroid	GD3 synthase	CHEBI:35341	25280(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Activation Activation|nmod|END_ENTITY	Activation of GD3_synthase by sex steroid hormones in cultured rat hepatocytes .
1295809	1	steroid	292,299	GH	281,283	steroid	GH	CHEBI:35341	81668(Tax:10116)	Chemical	Gene	interactions|compound|START_ENTITY interactions|compound|END_ENTITY	Animal experiments and clinical studies on the interactions between growth_hormone -LRB- GH -RRB- and the male_hypothalamic-pituitary-gonadal_axis have predominantly concentrated on GH and sex steroid interactions in the regulation of growth and development , or on the metabolic effects of GH .
18178009	0	steroid	19,26	GIRK2	39,44	steroid	GIRK2	CHEBI:35341	25743(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|transcription transcription|compound|END_ENTITY	Effects of gonadal steroid hormones on GIRK2 gene transcription in the rat central nervous system .
21809103	0	steroid	68,75	G_protein-coupled_estrogen_receptor	13,48	steroid	G protein-coupled estrogen receptor	CHEBI:35341	2852	Chemical	Gene	START_ENTITY|nsubj|Induction Induction|nmod|END_ENTITY	Induction of G_protein-coupled_estrogen_receptor -LRB- GPER -RRB- and nuclear steroid hormone receptors by gonadotropins in human granulosa cells .
12960354	0	steroid	87,94	Glucocorticoid_receptor	0,23	steroid	Glucocorticoid receptor	CHEBI:35341	2908	Chemical	Gene	ligands|amod|START_ENTITY effects|nmod|ligands leads|nmod|effects leads|nsubj|nitration nitration|compound|END_ENTITY	Glucocorticoid_receptor nitration leads to enhanced anti-inflammatory effects of novel steroid ligands .
6948600	0	steroid	52,59	Glucocorticoid_receptor	0,23	steroid	Glucocorticoid receptor	CHEBI:35341	2908	Chemical	Gene	hormones|amod|START_ENTITY sensitivity|nmod|hormones sensitivity|nsubj|END_ENTITY	Glucocorticoid_receptor and in vitro sensitivity to steroid hormones in human lymphoproliferative_diseases and myeloid_leukemia .
10844203	0	steroid	8,15	GnRH	47,51	steroid	GnRH	CHEBI:35341	443529(Tax:9940)	Chemical	Gene	START_ENTITY|nmod|regulation regulation|nmod|secretion secretion|compound|END_ENTITY	Gonadal steroid receptors in the regulation of GnRH secretion in farm animals .
16061071	0	steroid	31,38	GnRH	18,22	steroid	GnRH	CHEBI:35341	2796	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of salmon GnRH and sex steroid hormones on expression of genes encoding growth_hormone / prolactin/somatolactin family hormones and a pituitary-specific transcription factor in masu salmon pituitary cells in vitro .
10596723	0	steroid	53,60	Growth_hormone	0,14	steroid	Growth hormone	CHEBI:35341	2688	Chemical	Gene	effect|nmod|START_ENTITY has|dobj|effect has|nsubj|END_ENTITY	Growth_hormone has no direct effect on human adrenal steroid and insulin-like growth factor-binding protein secretion .
11738095	0	steroid	72,79	Growth_hormone	0,14	steroid	Growth hormone	CHEBI:35341	81668(Tax:10116)	Chemical	Gene	catabolism|amod|START_ENTITY established|dobj|catabolism established|nsubj|counteracts counteracts|compound|END_ENTITY	Growth_hormone and insulin-like_growth_factor-I counteracts established steroid catabolism in rats by effects on hepatic amino-N degradation .
19231263	0	steroid	97,104	Growth_hormone	0,14	steroid	Growth hormone	CHEBI:35341	81668(Tax:10116)	Chemical	Gene	balance|nmod|START_ENTITY effects|nmod|balance effects|amod|END_ENTITY	Growth_hormone and growth_hormone secretagogue effects on nitrogen balance and urea synthesis in steroid treated rats .
6665012	0	steroid	59,66	Growth_hormone	0,14	steroid	Growth hormone	CHEBI:35341	81668(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY regulator|nmod|metabolism END_ENTITY|dep|regulator	Growth_hormone : a regulator of the sexually differentiated steroid metabolism in rat liver .
1639815	0	steroid	101,108	HNF-4	138,143	steroid	HNF-4	CHEBI:35341	3172	Chemical	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Transcriptional regulation of human apolipoprotein genes ApoB , ApoCIII , and ApoAII by members of the steroid hormone receptor superfamily HNF-4 , ARP-1 , EAR-2 , and EAR-3 .
2279702	0	steroid	67,74	HNF-4	36,41	steroid	HNF-4	CHEBI:35341	3172	Chemical	Gene	superfamily|amod|START_ENTITY member|nmod|superfamily member|nsubj|END_ENTITY	Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily .
9408084	0	steroid	43,50	HNF-4	30,35	steroid	HNF-4	CHEBI:35341	15378(Tax:10090)	Chemical	Gene	15alpha-hydroxylase|amod|START_ENTITY gene|amod|15alpha-hydroxylase END_ENTITY|nmod|gene	Transcriptional regulation by HNF-4 of the steroid 15alpha-hydroxylase P450 -LRB- Cyp2a-4 -RRB- gene in mouse liver .
10689618	0	steroid	38,45	HSP90	27,32	steroid	HSP90	CHEBI:35341	3320	Chemical	Gene	receptors|amod|START_ENTITY END_ENTITY|nmod|receptors	-LSB- Functional interaction of HSP90 with steroid receptors -RSB- .
10666107	0	steroid	10,17	ICAM-1	39,45	steroid	ICAM-1	CHEBI:35341	3383	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of steroid on hyperoxia-induced ICAM-1 expression in pulmonary endothelial cells .
19236347	0	steroid	12,19	IFN-gamma	93,102	steroid	IFN-gamma	CHEBI:35341	3458	Chemical	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	The adrenal steroid response during tuberculosis and its effects on the mycobacterial-driven IFN-gamma production of patients and their household contacts .
9858313	0	steroid	55,62	IFN-gamma	81,90	steroid	IFN-gamma	CHEBI:35341	15978(Tax:10090)	Chemical	Gene	16-Epiestriol|appos|START_ENTITY inhibit|nsubj|16-Epiestriol inhibit|dobj|production production|amod|END_ENTITY	16-Epiestriol , a novel anti-inflammatory nonglycogenic steroid , does not inhibit IFN-gamma production by murine splenocytes .
10925211	0	steroid	74,81	IGF-I	12,17	steroid	IGF-I	CHEBI:35341	100008668(Tax:9986)	Chemical	Gene	secretion|amod|START_ENTITY control|nmod|secretion kinase|nmod|control kinase|nsubj|role role|nmod|END_ENTITY	The role of IGF-I , cAMP/protein kinase A and MAP-kinase in the control of steroid secretion , cyclic nucleotide production , granulosa cell proliferation and preimplantation embryo development in rabbits .
12044613	0	steroid	88,95	IGF-I	73,78	steroid	IGF-I	CHEBI:35341	104978413	Chemical	Gene	production|amod|START_ENTITY Influence|dep|production Influence|nmod|gonadotropins gonadotropins|nmod|insulin insulin|appos|END_ENTITY	Influence of gonadotropins on insulin - and insulin-like growth factor-I -LRB- IGF-I -RRB- - induced steroid production by bovine granulosa cells .
14674122	0	steroid	174,181	IGF-I	90,95	steroid	IGF-I	CHEBI:35341	3479	Chemical	Gene	phenotype|amod|START_ENTITY depends|nmod|phenotype depends|nsubj|-RSB- -RSB-|amod|END_ENTITY	The impact of progesterone on simultaneous , local secretion of IGFBP-3 and IGF-I -LSB- IGFBP-3 / IGF-I index -RSB- by human malignant and non-malignant breast explants depends on tissue steroid receptor phenotype .
26979943	0	steroid	48,55	IGF-I	10,15	steroid	IGF-I	D013256	3479	Chemical	Gene	pathways|amod|START_ENTITY intensification|nmod|pathways Effect|nmod|intensification Effect|nmod|END_ENTITY	Effect of IGF-I and TNF-a on intensification of steroid pathways in women with PCOS phenotypes are not identical .
8020171	0	steroid	27,34	IGF-I	0,5	steroid	IGF-I	CHEBI:35341	3479	Chemical	Gene	secretion|amod|START_ENTITY influence|nmod|secretion influence|nsubj|END_ENTITY	IGF-I and EGF influence on steroid secretion and morphology of human granulosa cells of IVF-cycles and natural cycles in vitro .
9169115	0	steroid	95,102	IGF-I	86,91	steroid	IGF-I	CHEBI:35341	3479	Chemical	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	Ovarian_receptors_for_insulin_and_insulin-like_growth factor I -LRB- IGF-I -RRB- and effects of IGF-I on steroid production by isolated follicular layers of the preovulatory coho_salmon ovarian follicle .
9640414	0	steroid	108,115	IGF-I	11,16	steroid	IGF-I	CHEBI:35341	3479	Chemical	Gene	levels|compound|START_ENTITY relation|nmod|levels levels|dep|relation levels|amod|END_ENTITY	Serum free IGF-I , total IGF-I , IGFBP-1 and IGFBP-3 levels in an elderly population : relation to age and sex steroid levels .
9640414	0	steroid	108,115	IGF-I	24,29	steroid	IGF-I	CHEBI:35341	3479	Chemical	Gene	levels|compound|START_ENTITY relation|nmod|levels levels|dep|relation levels|compound|END_ENTITY	Serum free IGF-I , total IGF-I , IGFBP-1 and IGFBP-3 levels in an elderly population : relation to age and sex steroid levels .
11996939	0	steroid	76,83	IL-1beta	64,72	steroid	IL-1beta	CHEBI:35341	3553	Chemical	Gene	activity|amod|START_ENTITY END_ENTITY|nmod|activity	Regulation of estrogen activity in human endometrium : effect of IL-1beta on steroid sulfatase activity in human endometrial stromal cells .
15480901	0	steroid	21,28	IgA_nephropathy	64,79	steroid	IgA nephropathy	CHEBI:35341	60498	Chemical	Gene	therapy|amod|START_ENTITY effectiveness|nmod|therapy effectiveness|nmod|patients patients|nmod|END_ENTITY	The effectiveness of steroid therapy for patients with advanced IgA_nephropathy and impaired_renal_function .
18286351	0	steroid	32,39	IgA_nephropathy	66,81	steroid	IgA nephropathy	CHEBI:35341	60498	Chemical	Gene	therapy|amod|START_ENTITY therapy|nmod|patients patients|nmod|END_ENTITY	Clinical assessment of low-dose steroid therapy for patients with IgA_nephropathy : a prospective study in a single center .
21865690	0	steroid	28,35	IgA_nephropathy	80,95	steroid	IgA nephropathy	CHEBI:35341	60498	Chemical	Gene	therapy|amod|START_ENTITY combined|nmod|therapy combined|nsubj|remission remission|nmod|END_ENTITY	Tonsillectomy combined with steroid pulse therapy induces clinical remission of IgA_nephropathy .
23224025	0	steroid	63,70	IgA_nephropathy	115,130	steroid	IgA nephropathy	CHEBI:35341	60498	Chemical	Gene	therapy|amod|START_ENTITY therapy|nmod|survival survival|nmod|patients patients|nmod|END_ENTITY	The predictive value of attenuated proteinuria at 1 year after steroid therapy for renal survival in patients with IgA_nephropathy .
8281940	0	steroid	39,46	Insulin-like_growth_factor-1	0,28	steroid	Insulin-like growth factor-1	CHEBI:35341	3479	Chemical	Gene	START_ENTITY|nsubj|modulates modulates|amod|END_ENTITY	Insulin-like_growth_factor-1 modulates steroid hormone effects on osteocalcin synthesis in human MG-63 osteosarcoma cells .
15365604	0	steroid	50,57	Interleukin-2	0,13	steroid	Interleukin-2	CHEBI:35341	3558	Chemical	Gene	START_ENTITY|nsubj|receptor receptor|amod|END_ENTITY	Interleukin-2 receptor antagonists and aggressive steroid minimization strategies for kidney transplant patients .
23339932	0	steroid	33,40	Interleukin-6	0,13	steroid	Interleukin-6	D013256	3569	Chemical	Gene	resistance|amod|START_ENTITY associated|nmod|resistance associated|nsubjpass|END_ENTITY	Interleukin-6 is associated with steroid resistance and reflects disease activity in severe pediatric ulcerative_colitis .
23379382	0	steroid	98,105	Interleukin-6	0,13	steroid	Interleukin-6	CHEBI:35341	403985(Tax:9615)	Chemical	Gene	responsive|amod|START_ENTITY meningitis-arteritis|amod|responsive END_ENTITY|nmod|meningitis-arteritis	Interleukin-6 , vascular_endothelial_growth_factor and transforming_growth_factor_beta_1 in canine steroid responsive meningitis-arteritis .
11456279	0	steroid	16,23	Leptin	0,6	steroid	Leptin	CHEBI:35341	3952	Chemical	Gene	biosynthesis|amod|START_ENTITY inhibits|dobj|biosynthesis inhibits|nsubj|END_ENTITY	Leptin inhibits steroid biosynthesis by human granulosa-lutein cells .
9888542	0	steroid	26,33	Leptin	0,6	steroid	Leptin	CHEBI:35341	280836(Tax:9913)	Chemical	Gene	system|amod|START_ENTITY down-regulates|dobj|system down-regulates|nsubj|END_ENTITY	Leptin down-regulates the steroid producing system in the adrenal .
17403418	0	steroid	27,34	MMP-1	14,19	steroid	MMP-1	CHEBI:35341	4312	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of MMP-1 by sex steroid hormones in fibroblasts derived from the female pelvic floor .
16595724	0	steroid	19,26	MUC1	62,66	steroid	MUC1	CHEBI:35341	4582	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	The effects of sex steroid hormones and interleukin-1-beta on MUC1 expression in endometrial epithelial cell lines .
21883211	0	steroid	2,9	NR2A	31,35	steroid	NR2A	CHEBI:35341	2903	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	A steroid modulatory domain in NR2A collaborates with NR1 exon-5 to control NMDAR modulation by pregnenolone_sulfate and protons .
15150412	0	steroid	2,9	NR2B	31,35	steroid	NR2B	CHEBI:35341	2904	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	A steroid modulatory domain on NR2B controls N-methyl-D-aspartate receptor proton sensitivity .
18599618	0	steroid	238,245	NUR77	28,33	steroid	NUR77	CHEBI:35341	3164	Chemical	Gene	biosynthesis|amod|START_ENTITY step|nmod|biosynthesis membrane|appos|step transport|nmod|membrane kinase|ccomp|transport mediated|dep|kinase containing|parataxis|mediated +|acl|containing Leydig|nmod|+ regulates|advcl|Leydig regulates|nsubj|END_ENTITY	The orphan nuclear receptor NUR77 regulates hormone-induced StAR transcription in Leydig cells through cooperation with Ca2 + / calmodulin-dependent protein kinase I. Cholesterol transport in the mitochondrial membrane , an essential step of steroid biosynthesis , is mediated by a protein complex containing the steroidogenic_acute_regulatory -LRB- StAR -RRB- protein .
8528019	0	steroid	24,31	Neurotrophin-3	0,14	steroid	Neurotrophin-3	CHEBI:35341	101832672	Chemical	Gene	START_ENTITY|nsubj|augments augments|amod|END_ENTITY	Neurotrophin-3 augments steroid secretion by hamster ovarian follicles in vitro .
13129926	0	steroid	11,18	Nur77	28,33	steroid	Nur77	CHEBI:35341	15370(Tax:10090)	Chemical	Gene	Nor-1|amod|START_ENTITY Nor-1|compound|END_ENTITY	The orphan steroid receptor Nur77 family member Nor-1 is essential for early mouse embryogenesis .
14657025	0	steroid	81,88	Nur77	68,73	steroid	Nur77	CHEBI:35341	3164	Chemical	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Transcriptional activation of known and novel apoptotic pathways by Nur77 orphan steroid receptor .
1922099	0	steroid	77,84	Nur77	30,35	steroid	Nur77	CHEBI:35341	3164	Chemical	Gene	superfamily|amod|START_ENTITY member|nmod|superfamily END_ENTITY|appos|member	Transcriptional activation by Nur77 , a growth factor-inducible member of the steroid hormone receptor superfamily .
7565789	0	steroid	31,38	Nur77	18,23	steroid	Nur77	CHEBI:35341	3164	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|orphan orphan|amod|END_ENTITY	Regulation of the Nur77 orphan steroid receptor in activation-induced apoptosis .
7981602	0	steroid	47,54	Nur77	34,39	steroid	Nur77	CHEBI:35341	3164	Chemical	Gene	START_ENTITY|nsubj|characterization characterization|nmod|orphan orphan|amod|END_ENTITY	Molecular characterization of the Nur77 orphan steroid receptor in apoptosis .
9155013	0	steroid	52,59	Nur77	29,34	steroid	Nur77	CHEBI:35341	15370(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|redundancy redundancy|nmod|END_ENTITY	Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis .
9496246	0	steroid	23,30	Nur77	0,5	steroid	Nur77	CHEBI:35341	15370(Tax:10090)	Chemical	Gene	superfamily|amod|START_ENTITY member|nmod|superfamily END_ENTITY|appos|member	Nur77 , a member of the steroid receptor superfamily , antagonizes negative feedback of ACTH synthesis and secretion by glucocorticoid in pituitary corticotrope cells .
25657046	0	steroid	51,58	OxeR1	0,5	steroid	OxeR1	CHEBI:35341	165140	Chemical	Gene	production|compound|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	OxeR1 regulates angiotensin_II and cAMP-stimulated steroid production in human H295R adrenocortical cells .
14658589	1	steroid	142,149	PCNA	193,197	steroid	PCNA	CHEBI:35341	5111	Chemical	Gene	status|amod|START_ENTITY status|appos|END_ENTITY	An immunohistochemical study including correlations with p53 , steroid receptor status and proliferative indices -LRB- PCNA , MIB1 -RRB- .
8115018	0	steroid	17,24	POMC	39,43	steroid	POMC	CHEBI:35341	24664(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|regulation regulation|nmod|expression expression|compound|END_ENTITY	Dopamine and sex steroid regulation of POMC gene expression in the hypothalamus .
8347494	0	steroid	59,66	PS2	0,3	steroid	PS2	CHEBI:35341	338412	Chemical	Gene	status|amod|START_ENTITY tool|nmod|status END_ENTITY|dep|tool	PS2 in breast_cancer -- alternative or complementary tool to steroid receptor status ?
27021728	0	steroid	84,91	Prolactin	0,9	steroid	Prolactin	D013256	24683(Tax:10116)	Chemical	Gene	imbalance|amod|START_ENTITY subjected|nmod|imbalance subjected|nsubj|profiles profiles|compound|END_ENTITY	Prolactin , EGFR , vimentin and a-actin profiles in elderly rat prostate subjected to steroid hormonal imbalance .
6096247	0	steroid	45,52	Prolactin	0,9	steroid	Prolactin	CHEBI:35341	24683(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Prolactin stimulates and potentiates adrenal steroid secretion in vitro .
6229966	0	steroid	77,84	Prolactin	0,9	steroid	Prolactin	CHEBI:35341	5617	Chemical	Gene	pattern|amod|START_ENTITY correlation|nmod|pattern secretion|dep|correlation secretion|compound|END_ENTITY	Prolactin secretion in polycystic_ovary_syndrome -LRB- PCO -RRB- : correlation with the steroid pattern .
7037530	7	steroid	483,490	Prolactin	457,466	steroid	prolactin	CHEBI:35341	24683(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY increased|nmod|treatment increased|nsubj|END_ENTITY	Prolactin increased after steroid treatment and alcohol drinking in the controls .
15206558	4	steroid	490,497	SP-A	526,530	steroid	SP-A	CHEBI:35341	653509	Chemical	Gene	therapy|amod|START_ENTITY therapy|nmod|END_ENTITY	He showed good response to steroid therapy and serum levels of SP-A and SP-D returned to almost normal levels .
17541154	0	steroid	41,48	SRB-RGS	75,82	steroid	SRB-RGS	CHEBI:35341	54293(Tax:10116)	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Characterization and identification of a steroid receptor-binding protein , SRB-RGS .
19701241	0	steroid	48,55	SRC	79,82	steroid	SRC	CHEBI:35341	6714	Chemical	Gene	family|amod|START_ENTITY family|appos|END_ENTITY	Normal and cancer-related functions of the p160 steroid receptor co-activator -LRB- SRC -RRB- family .
11355945	0	steroid	36,43	SRD5A2	68,74	steroid	SRD5A2	CHEBI:35341	6716	Chemical	Gene	5-alpha-reductase|amod|START_ENTITY gene|amod|5-alpha-reductase gene|appos|END_ENTITY	A missense substitution A49T in the steroid 5-alpha-reductase gene -LRB- SRD5A2 -RRB- is not associated with prostate_cancer in Finland .
11381197	0	steroid	56,63	SRD5A2	40,46	steroid	SRD5A2	CHEBI:35341	6716	Chemical	Gene	type|amod|START_ENTITY alpha-reductase|dep|type END_ENTITY|dep|alpha-reductase	Evidence for an association between the SRD5A2 -LRB- type II steroid 5 alpha-reductase -RRB- locus and prostate_cancer in Italian patients .
19215786	0	steroid	39,46	SRD5A2	73,79	steroid	SRD5A2	CHEBI:35341	6716	Chemical	Gene	5alpha-reductase|amod|START_ENTITY gene|amod|5alpha-reductase gene|appos|END_ENTITY	Association among polymorphisms in the steroid 5alpha-reductase type II -LRB- SRD5A2 -RRB- gene , prostate_cancer risk , and pathologic characteristics of prostate_tumors in an Ecuadorian population .
25077171	0	steroid	101,108	SRD5A2	130,136	steroid	SRD5A2	D013256	6716	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	46 , XY disorder of sexual development resulting from a novel monoallelic mutation -LRB- p.Ser31Phe -RRB- in the steroid 5a-reductase type-2 -LRB- SRD5A2 -RRB- gene .
25266188	0	steroid	37,44	SRD5A2	67,73	steroid	SRD5A2	CHEBI:35341	6716	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Try235Phe homozygous mutation of the steroid 5-a reductase_type_2 -LRB- SRD5A2 -RRB- gene in a Turkish patient .
8751382	0	steroid	37,44	SRD5A2	76,82	steroid	SRD5A2	CHEBI:35341	6716	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic linkage mapping of the human steroid 5 alpha-reductase type 2 gene -LRB- SRD5A2 -RRB- close to D2S352 on chromosome region 2p23 -- > p22 .
18937300	0	steroid	19,26	STS	38,41	steroid	STS	CHEBI:35341	412	Chemical	Gene	sulfatase|amod|START_ENTITY gene|amod|sulfatase gene|appos|END_ENTITY	Association of the steroid sulfatase -LRB- STS -RRB- gene with attention deficit_hyperactivity_disorder .
19200188	0	steroid	78,85	STS	97,100	steroid	STS	CHEBI:35341	412	Chemical	Gene	sulfatase|amod|START_ENTITY sulfatase|appos|END_ENTITY	Atypical X-linked_ichthyosis in a patient with a large deletion involving the steroid sulfatase -LRB- STS -RRB- gene .
20862695	0	steroid	21,28	STS	40,43	steroid	STS	CHEBI:35341	412	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms of the steroid sulfatase -LRB- STS -RRB- gene are associated with attention_deficit_hyperactivity_disorder and influence brain tissue mRNA expression .
20941942	0	steroid	17,24	STS	50,53	steroid	STS	CHEBI:35341	412	Chemical	Gene	deletion|amod|START_ENTITY detection|nmod|deletion detection|appos|END_ENTITY	The detection of steroid sulfatase gene deletion -LRB- STS -RRB- in Egyptian males with X-linked_ichthyosis .
22542502	0	steroid	106,113	STS	125,128	steroid	STS	CHEBI:35341	412	Chemical	Gene	sulfatase|amod|START_ENTITY sulfatase|appos|END_ENTITY	Synthesis of 2 - -LSB- 11C -RSB- methoxy-3 ,17 b-O , O-bis -LRB- sulfamoyl -RRB- estradiol as a new potential PET agent for imaging of steroid sulfatase -LRB- STS -RRB- in cancers .
2338343	0	steroid	14,21	STS	33,36	steroid	STS	CHEBI:35341	412	Chemical	Gene	deletions|amod|START_ENTITY deletions|appos|END_ENTITY	Screening for steroid sulfatase -LRB- STS -RRB- gene deletions by multiplex DNA amplification .
25042472	4	steroid	425,432	STS	444,447	steroid	STS	CHEBI:35341	412	Chemical	Gene	sulfatase|amod|START_ENTITY sulfatase|appos|END_ENTITY	The enzyme steroid sulfatase -LRB- STS -RRB- converts sulfated steroids into active forms in peripheral tissues .
12933903	0	steroid	41,48	Steroid_receptor_coactivator_1	0,30	steroid	Steroid receptor coactivator 1	CHEBI:35341	8648	Chemical	Gene	links|dobj|START_ENTITY links|nsubj|END_ENTITY	Steroid_receptor_coactivator_1 links the steroid and interferon_gamma response pathways .
8662223	0	steroid	19,26	Sts	43,46	steroid	Sts	CHEBI:35341	24800(Tax:10116)	Chemical	Gene	Cloning|dep|START_ENTITY Cloning|nsubj|gene gene|appos|END_ENTITY	Cloning of the rat steroid sulfatase gene -LRB- Sts -RRB- , a non-pseudoautosomal X-linked gene that undergoes X inactivation .
8673109	0	steroid	52,59	Sts	77,80	steroid	Sts	CHEBI:35341	412	Chemical	Gene	START_ENTITY|dobj|gene gene|appos|END_ENTITY	Cloning and expression of the mouse pseudoautosomal steroid sulphatase gene -LRB- Sts -RRB- .
21778277	0	steroid	61,68	TLR9	10,14	steroid	TLR9	CHEBI:35341	54106	Chemical	Gene	therapy|amod|START_ENTITY END_ENTITY|nmod|therapy	Tonsillar TLR9 expression and efficacy of tonsillectomy with steroid pulse therapy in IgA_nephropathy patients .
21783824	0	steroid	52,59	TM3	81,84	steroid	TM3	CHEBI:35341	22003(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Diesel exhaust particles suppress expression of sex steroid hormone receptors in TM3 mouse Leydig cells .
11304678	2	steroid	340,347	VEGF	308,312	steroid	VEGF	CHEBI:35341	7422	Chemical	Gene	hormones|amod|START_ENTITY regulated|nmod|hormones regulated|nsubjpass|expression expression|compound|END_ENTITY	VEGF expression is regulated by steroid hormones in a number of systems , including T47-D human breast_cancer cells in which VEGF protein levels are elevated by progestins .
22427602	0	steroid	30,37	VEGF-A	45,51	steroid	VEGF-A	CHEBI:35341	22339(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|amod|END_ENTITY	Larger therapeutic window for steroid versus VEGF-A inhibitor in inflammatory angiogenesis : surprisingly similar impact on leukocyte infiltration .
3512260	0	steroid	119,126	VIP	110,113	steroid	VIP	CHEBI:35341	117064(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY END_ENTITY|nmod|secretion	The immature rat ovary is innervated by vasoactive_intestinal_peptide -LRB- VIP -RRB- - containing fibers and responds to VIP with steroid secretion .
15764150	0	steroid	121,128	Vascular_endothelial_growth_factor	0,34	steroid	Vascular endothelial growth factor	CHEBI:35341	7422	Chemical	Gene	correlate|xcomp|START_ENTITY correlate|nsubj|expression expression|amod|END_ENTITY	Vascular_endothelial_growth_factor expression and microvessel parameters of colonic_mucosa correlate with sensitivity to steroid in patients with ulcerative_colitis .
7867583	0	steroid	23,30	Vasopressin	0,11	steroid	Vasopressin	CHEBI:35341	551	Chemical	Gene	START_ENTITY|nsubj|stimulates stimulates|compound|END_ENTITY	Vasopressin stimulates steroid secretion in human adrenal glands : comparison with angiotensin-II effect .
10757787	0	steroid	49,56	Ydj1	21,25	steroid	Ydj1	CHEBI:35341	855661(Tax:4932)	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	A role for the Hsp40 Ydj1 in repression of basal steroid receptor activity in yeast .
1464664	0	steroid	43,50	activin	20,27	steroid	activin	CHEBI:35341	83729	Chemical	Gene	synthesis|amod|START_ENTITY effects|nmod|synthesis effects|nmod|END_ENTITY	Relative effects of activin and inhibin on steroid hormone synthesis in primate granulosa cells .
20492390	0	steroid	30,37	adiponectin	10,21	steroid	adiponectin	CHEBI:35341	9370	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of adiponectin and sex steroid hormones on bone_mineral_density and bone formation markers in postmenopausal women with subclinical_hyperthyroidism .
2990678	0	steroid	85,92	adrenocorticotropic_hormone	11,38	steroid	adrenocorticotropic hormone	CHEBI:35341	5443	Chemical	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	Effects of adrenocorticotropic_hormone , human_chorionic_gonadotropin , and insulin on steroid production by human adrenocortical_carcinoma cells in culture .
18401014	0	steroid	99,106	adrenomedullin	16,30	steroid	adrenomedullin	CHEBI:35341	25026(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY effects|nmod|secretion Coexpression|dep|effects Coexpression|nmod|END_ENTITY	Coexpression of adrenomedullin and its receptors in the reproductive system of the rat : effects on steroid secretion in rat ovary .
1855466	0	steroid	16,23	androgen-binding_protein	46,70	steroid	androgen-binding protein	CHEBI:35341	24775(Tax:10116)	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Analysis of the steroid binding domain of rat androgen-binding_protein .
10611280	0	steroid	149,156	androgen_receptor	63,80	steroid	androgen receptor	CHEBI:35341	367	Chemical	Gene	superfamily|amod|START_ENTITY pathway|nmod|superfamily Convergence|dep|pathway Convergence|nmod|repressors repressors|nmod|formation formation|nmod|END_ENTITY	Convergence of two repressors through heterodimer formation of androgen_receptor and testicular_orphan_receptor-4 : a unique signaling pathway in the steroid receptor superfamily .
11161315	0	steroid	136,143	androgen_receptor	100,117	steroid	androgen receptor	CHEBI:35341	367	Chemical	Gene	research|amod|START_ENTITY implications|nmod|research Generation|dep|implications Generation|nmod|line line|acl|expressing expressing|dobj|END_ENTITY	Generation of a mammalian cell line stably expressing a tetracycline-regulated epitope-tagged human androgen_receptor : implications for steroid hormone receptor research .
11894978	0	steroid	79,86	androgen_receptor	25,42	steroid	androgen receptor	CHEBI:35341	367	Chemical	Gene	START_ENTITY|nsubj|Lack Lack|nmod|influence influence|nmod|polymorphism polymorphism|compound|END_ENTITY	Lack of influence of the androgen_receptor gene CAG-repeat polymorphism on sex steroid status and bone metabolism in elderly men .
11997213	0	steroid	112,119	androgen_receptor	14,31	steroid	androgen receptor	CHEBI:35341	101838789	Chemical	Gene	hormones|amod|START_ENTITY cross-talk|nmod|hormones Regulation|dep|cross-talk Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of androgen_receptor mRNA expression in primary culture of Harderian gland cells : cross-talk between steroid hormones .
12350225	0	steroid	79,86	androgen_receptor	171,188	steroid	androgen receptor	CHEBI:35341	367	Chemical	Gene	gene|amod|START_ENTITY form|nmod|gene steroid_receptor_co-activator_protein|nmod|form steroid_receptor_co-activator_protein|dep|expression expression|nmod|cells cells|nmod|activity activity|compound|END_ENTITY	A novel steroid_receptor_co-activator_protein -LRB- SRAP -RRB- as an alternative form of steroid receptor RNA-activator gene : expression in prostate_cancer cells and enhancement of androgen_receptor activity .
12886517	0	steroid	24,31	androgen_receptor	81,98	steroid	androgen receptor	CHEBI:35341	11835(Tax:10090)	Chemical	Gene	specificity|amod|START_ENTITY preservation|nmod|specificity xenografts|nsubj|preservation xenografts|xcomp|having having|dobj|END_ENTITY	In vivo preservation of steroid specificity in CWR22 xenografts having a mutated androgen_receptor .
1472451	0	steroid	58,65	androgen_receptor	14,31	steroid	androgen receptor	CHEBI:35341	367	Chemical	Gene	hormones|amod|START_ENTITY level|nmod|hormones level|nsubj|Regulation Regulation|nmod|mRNA mRNA|compound|END_ENTITY	Regulation of androgen_receptor mRNA and protein level by steroid hormones in human mammary cancer cells .
15983373	0	steroid	9,16	androgen_receptor	97,114	steroid	androgen receptor	CHEBI:35341	11835(Tax:10090)	Chemical	Gene	coactivator|amod|START_ENTITY Roles|nmod|coactivator -1|nsubj|Roles -1|nmod|activity activity|compound|END_ENTITY	Roles of steroid receptor coactivator -LRB- SRC -RRB- -1 and transcriptional intermediary factor -LRB- TIF -RRB- 2 in androgen_receptor activity in mice .
16638015	0	steroid	14,21	androgen_receptor	69,86	steroid	androgen receptor	CHEBI:35341	367	Chemical	Gene	START_ENTITY|ccomp|regulates regulates|dobj|level level|compound|END_ENTITY	A neuroactive steroid 5alpha-androstane-3alpha ,17 beta-diol regulates androgen_receptor level in astrocytes .
17018919	0	steroid	82,89	androgen_receptor	112,129	steroid	androgen receptor	CHEBI:35341	367	Chemical	Gene	region|amod|START_ENTITY region|nmod|END_ENTITY	-LSB- Complete androgen insensitivity in an Icelandic family caused by mutation in the steroid binding region of the androgen_receptor . -RSB-
1775129	0	steroid	51,58	androgen_receptor	21,38	steroid	androgen receptor	CHEBI:35341	367	Chemical	Gene	binding|amod|START_ENTITY involved|nmod|binding involved|nsubj|Domains Domains|nmod|END_ENTITY	Domains of the human androgen_receptor involved in steroid binding , transcriptional activation , and subcellular localization .
2016261	0	steroid	80,87	androgen_receptor	38,55	steroid	androgen receptor	CHEBI:35341	24208(Tax:10116)	Chemical	Gene	affinity|nmod|START_ENTITY has|dobj|affinity has|nsubj|END_ENTITY	The Mr 90,000 heat_shock protein-free androgen_receptor has a high affinity for steroid , in contrast to the glucocorticoid receptor .
2127955	0	steroid	84,91	androgen_receptor	34,51	steroid	androgen receptor	CHEBI:35341	367	Chemical	Gene	characterization|nmod|START_ENTITY Overexpression|dep|characterization Overexpression|nmod|END_ENTITY	Overexpression of a partial human androgen_receptor in E. _ coli : characterization of steroid binding , DNA binding , and immunological properties .
21868758	0	steroid	21,28	androgen_receptor	49,66	steroid	androgen receptor	CHEBI:35341	367	Chemical	Gene	START_ENTITY|ccomp|activates activates|dobj|END_ENTITY	Intratumoral de novo steroid synthesis activates androgen_receptor in castration-resistant_prostate_cancer and is upregulated by treatment with CYP17A1 inhibitors .
2260966	0	steroid	94,101	androgen_receptor	47,64	steroid	androgen receptor	CHEBI:35341	367	Chemical	Gene	characteristics|amod|START_ENTITY affects|dobj|characteristics affects|nsubj|mutation mutation|nmod|domain domain|nmod|END_ENTITY	A mutation in the ligand binding domain of the androgen_receptor of human LNCaP cells affects steroid binding characteristics and response to anti-androgens .
22825604	0	steroid	78,85	androgen_receptor	14,31	steroid	androgen receptor	CHEBI:35341	367	Chemical	Gene	receptors|amod|START_ENTITY _|nmod|receptors _|nsubj|Expression Expression|nmod|END_ENTITY	Expression of androgen_receptor in breast_cancer _ its correlation with other steroid receptors _ growth factors .
24465978	0	steroid	64,71	androgen_receptor	26,43	steroid	androgen receptor	CHEBI:35341	367	Chemical	Gene	concentrations|amod|START_ENTITY associated|nmod|concentrations associated|nsubjpass|variations variations|nmod|END_ENTITY	Genetic variations in the androgen_receptor are associated with steroid concentrations and anthropometrics but not with muscle mass in healthy young men .
24936953	0	steroid	37,44	androgen_receptor	14,31	steroid	androgen receptor	CHEBI:35341	367	Chemical	Gene	conjugates|amod|START_ENTITY Targeting|nmod|conjugates Targeting|dobj|END_ENTITY	Targeting the androgen_receptor with steroid conjugates .
24948873	0	steroid	25,32	androgen_receptor	66,83	steroid	androgen receptor	D013256	367	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|activation activation|compound|END_ENTITY	Beyond T and DHT - novel steroid derivatives capable of wild type androgen_receptor activation .
25072891	0	steroid	98,105	androgen_receptor	18,35	steroid	androgen receptor	CHEBI:35341	100540598	Chemical	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of the androgen_receptor in the testes and the concentrations of gonadotropins and sex steroid hormones in male_turkeys -LRB- Meleagris_gallopavo -RRB- during growth and development .
2772967	0	steroid	14,21	androgen_receptor	39,56	steroid	androgen receptor	CHEBI:35341	367	Chemical	Gene	affinity|amod|START_ENTITY Modulation|nmod|affinity Modulation|nmod|END_ENTITY	Modulation of steroid affinity for the androgen_receptor by sucrose .
3302538	0	steroid	12,19	androgen_receptor	65,82	steroid	androgen receptor	CHEBI:35341	280675(Tax:9913)	Chemical	Gene	domains|amod|START_ENTITY Analysis|nmod|domains END_ENTITY|nsubj|Analysis	Analysis of steroid - and DNA-binding domains of the calf uterine androgen_receptor by limited proteolysis .
6323860	0	steroid	36,43	androgen_receptor	100,117	steroid	androgen receptor	CHEBI:35341	24208(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|method method|nmod|study study|nmod|modulation modulation|nmod|interaction interaction|compound|END_ENTITY	The use of a hydroxylapatite-filter steroid receptor assay method in the study of the modulation of androgen_receptor interaction .
6605183	0	steroid	92,99	androgen_receptor	18,35	steroid	androgen receptor	CHEBI:35341	367	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of the androgen_receptor in human genital skin fibroblasts , with a review of sex steroid receptor regulation by homologous and heterologous steroids .
6658893	0	steroid	20,27	androgen_receptor	55,72	steroid	androgen receptor	CHEBI:35341	367	Chemical	Gene	specificity|amod|START_ENTITY specificity|nmod|END_ENTITY	Characterization of steroid binding specificity of the androgen_receptor in human foreskin fibroblasts .
6891012	0	steroid	205,212	androgen_receptor	109,126	steroid	androgen receptor	CHEBI:35341	24208(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY role|nmod|metabolism affinities|dep|role affinities|nmod|END_ENTITY	Relative binding affinities of testosterone , 19-nortestosterone and their 5 alpha-reduced derivatives to the androgen_receptor and to other androgen-binding proteins : a suggested role of 5 alpha-reductive steroid metabolism in the dissociation of `` myotropic '' and `` androgenic '' activities of 19-nortestosterone .
8246999	0	steroid	146,153	androgen_receptor	9,26	steroid	androgen receptor	CHEBI:35341	367	Chemical	Gene	receptors|amod|START_ENTITY box|nmod|receptors residue|nmod|box function|nmod|residue identification|nmod|function END_ENTITY|dep|identification	A mutant androgen_receptor from patients with Reifenstein_syndrome : identification of the function of a conserved alanine residue in the D box of steroid receptors .
9932567	0	steroid	21,28	androgen_receptor	43,60	steroid	androgen receptor	CHEBI:35341	574293(Tax:9544)	Chemical	Gene	START_ENTITY|dobj|regulation regulation|nmod|expression expression|compound|END_ENTITY	Localization and sex steroid regulation of androgen_receptor gene expression in rhesus_monkey uterus .
1499050	0	steroid	38,45	angiotensin_II	20,34	steroid	angiotensin II	CHEBI:35341	183	Chemical	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	In-vitro effects of angiotensin_II on steroid production by hamster ovarian follicles and on ultrastructure of the theca interna .
25657046	0	steroid	51,58	angiotensin_II	16,30	steroid	angiotensin II	CHEBI:35341	183	Chemical	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	OxeR1 regulates angiotensin_II and cAMP-stimulated steroid production in human H295R adrenocortical cells .
3006413	0	steroid	58,65	angiotensin_II	10,24	steroid	angiotensin II	CHEBI:35341	24179(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of angiotensin_II on aldosterone and its precursor steroid production in adrenal_zona glomerulosa cells from heparin-treated rats .
4288541	0	steroid	40,47	angiotensin_II	14,28	steroid	angiotensin II	CHEBI:35341	24179(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|END_ENTITY	The effect of angiotensin_II on adrenal steroid synthesis in the rat .
844145	0	steroid	29,36	angiotensin_II	11,25	steroid	angiotensin II	CHEBI:35341	183	Chemical	Gene	metabolism|amod|START_ENTITY Effects|nmod|metabolism Effects|nmod|END_ENTITY	Effects of angiotensin_II on steroid metabolism and hepatic blood flow in man .
9757019	0	steroid	8,15	angiotensin_II	38,52	steroid	angiotensin II	CHEBI:35341	24179(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|regulation regulation|nmod|subtypes subtypes|amod|END_ENTITY	Adrenal steroid regulation of central angiotensin_II receptor subtypes and oxytocin receptors in rat brain .
976493	0	steroid	52,59	angiotensin_II	11,25	steroid	angiotensin II	CHEBI:35341	24179(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY study|dobj|secretion blockade|xcomp|study blockade|nsubj|use use|nmod|END_ENTITY	The use of angiotensin_II blockade to study adrenal steroid secretion .
9419781	0	steroid	52,59	apolipoprotein_B	72,88	steroid	apolipoprotein B	CHEBI:35341	338	Chemical	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Regulatory effects of multifunctional cytokines and steroid hormones on apolipoprotein_B production by human fetal hepatocytes .
3428360	0	steroid	133,140	aromatase	141,150	steroid	aromatase	CHEBI:35341	25147(Tax:10116)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Prevention of the anovulatory_syndrome and testosterone-induced rise in catecholamine level in the hypothalamus of newborn rats with steroid aromatase inhibitors .
2830068	0	steroid	69,76	atrial_natriuretic_factor	10,35	steroid	atrial natriuretic factor	CHEBI:35341	24602(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of atrial_natriuretic_factor on aldosterone and its precursor steroid production in adrenal zona glomerulosa cells from spontaneously hypertensive rats .
16188438	0	steroid	17,24	c-erbB-2	113,121	steroid	c-erbB-2	CHEBI:35341	2064	Chemical	Gene	receptors|amod|START_ENTITY receptors|dep|END_ENTITY	Co-expression of steroid hormone receptors -LRB- estrogen receptor alpha and/or progesterone receptors -RRB- and Her2/neu -LRB- c-erbB-2 -RRB- in breast_cancer : clinical outcome following tamoxifen-based adjuvant therapy .
9486154	0	steroid	19,26	calcitonin	53,63	steroid	calcitonin	CHEBI:35341	24241(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Effects of ovarian steroid hormones and thyroxine on calcitonin secretion in pregnant rats .
6894051	0	steroid	24,31	complement_C3	47,60	steroid	complement C3	CHEBI:35341	718	Chemical	Gene	START_ENTITY|nmod|activities activities|amod|END_ENTITY	-LSB- Effects of intrapartum steroid prophylaxis on complement_C3 and total complement activities -LRB- author 's transl -RRB- -RSB- .
19011238	0	steroid	90,97	corticosteroid-binding_globulin	22,53	steroid	corticosteroid-binding globulin	CHEBI:35341	866	Chemical	Gene	START_ENTITY|nsubj|Residues Residues|nmod|reactive_center_loop reactive_center_loop|amod|END_ENTITY	Residues in the human corticosteroid-binding_globulin reactive_center_loop that influence steroid binding before and after elastase cleavage .
19643161	0	steroid	34,41	corticosteroid-binding_globulin	75,106	steroid	corticosteroid-binding globulin	CHEBI:35341	866	Chemical	Gene	hormone|amod|START_ENTITY basis|nmod|hormone binding|nsubj|basis binding|nmod|END_ENTITY	Molecular and structural basis of steroid hormone binding and release from corticosteroid-binding_globulin .
20610591	0	steroid	57,64	corticosteroid-binding_globulin	6,37	steroid	corticosteroid-binding globulin	CHEBI:35341	866	Chemical	Gene	START_ENTITY|nsubj|variant variant|amod|END_ENTITY	Novel corticosteroid-binding_globulin variant that lacks steroid binding activity .
618541	0	steroid	35,42	corticosteroid-binding_globulin	66,97	steroid	corticosteroid-binding globulin	CHEBI:35341	866	Chemical	Gene	interaction|amod|START_ENTITY studies|nmod|interaction studies|nmod|END_ENTITY	Kinetic and equilibrium studies on steroid interaction with human corticosteroid-binding_globulin .
8031716	0	steroid	89,96	corticosteroid-binding_globulin	46,77	steroid	corticosteroid-binding globulin	CHEBI:35341	866	Chemical	Gene	binding|amod|START_ENTITY impact|nmod|binding Substitutions|dep|impact Substitutions|nmod|residues residues|nmod|END_ENTITY	Substitutions of tryptophan residues in human corticosteroid-binding_globulin : impact on steroid binding and glycosylation .
8419363	0	steroid	89,96	corticosteroid-binding_globulin	23,54	steroid	corticosteroid-binding globulin	CHEBI:35341	866	Chemical	Gene	necessary|nmod|START_ENTITY necessary|nsubj|Glycosylation Glycosylation|nmod|END_ENTITY	Glycosylation of human corticosteroid-binding_globulin at aspargine 238 is necessary for steroid binding .
9768330	0	steroid	15,22	corticosteroid-binding_globulin	35,66	steroid	corticosteroid-binding globulin	CHEBI:35341	866	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effects of sex steroid hormones on corticosteroid-binding_globulin gene expression in human endometrial_cancer cell line Ishikawa .
1320216	0	steroid	96,103	corticotropin-releasing_hormone	48,79	steroid	corticotropin-releasing hormone	CHEBI:35341	81648(Tax:10116)	Chemical	Gene	mRNA|compound|START_ENTITY mRNA|amod|END_ENTITY	Intrahippocampal colchicine alters hypothalamic corticotropin-releasing_hormone and hippocampal steroid receptor mRNA in rat brain .
25107325	0	steroid	105,112	cyp11a1	23,30	steroid	cyp11a1	CHEBI:35341	1583	Chemical	Gene	START_ENTITY|nsubj|analysis analysis|nmod|END_ENTITY	Expression analysis of cyp11a1 during gonadal development , recrudescence and after hCG induction and sex steroid analog treatment in the catfish , Clarias batrachus .
6773745	0	steroid	18,25	cytochrome_P-450	84,100	steroid	cytochrome P-450	CHEBI:35341	25251(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Reconstitution of steroid 17,20-lyase activity after separation and purification of cytochrome_P-450 and its reductase from rat testis microsomes .
22217822	0	steroid	74,81	cytochrome_P450scc	52,70	steroid	cytochrome P450scc	CHEBI:35341	29680(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY Regulation|nmod|synthesis Regulation|nmod|END_ENTITY	Regulation of cholesterol movement to mitochondrial cytochrome_P450scc in steroid hormone synthesis .
16917481	0	steroid	82,89	cytotoxic_T_lymphocyte_antigen_4	11,43	steroid	cytotoxic T lymphocyte antigen 4	CHEBI:35341	12477(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of cytotoxic_T_lymphocyte_antigen_4 -LRB- CTLA4 -RRB- signaling and locally applied steroid on retinal dysfunction by recoverin , cancer-associated_retinopathy antigen .
25976676	0	steroid	48,55	dedicator_of_cytokinesis_6	10,36	steroid	dedicator of cytokinesis 6	D013256	508023(Tax:9913)	Chemical	Gene	production|amod|START_ENTITY Effect|nmod|production Effect|nmod|END_ENTITY	Effect in dedicator_of_cytokinesis_6 -LRB- DOCK6 -RRB- on steroid production in theca cells of follicular_cysts .
1424568	0	steroid	18,25	delta-aminolaevulinic_acid_dehydratase	71,109	steroid	delta-aminolaevulinic acid dehydratase	CHEBI:35341	417273(Tax:9031)	Chemical	Gene	START_ENTITY|dobj|induction induction|nmod|END_ENTITY	Comparison of sex steroid hormone-dependent induction of chick oviduct delta-aminolaevulinic_acid_dehydratase during primary and secondary stimulation .
9131995	0	steroid	59,66	delta5-3-ketosteroid_isomerase	83,113	steroid	delta5-3-ketosteroid isomerase	CHEBI:35341	3283	Chemical	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	NMR studies of the secondary structure in solution and the steroid binding site of delta5-3-ketosteroid_isomerase in complexes with diamagnetic and paramagnetic steroids .
1913820	0	steroid	74,81	ecdysone_receptor	35,52	steroid	ecdysone receptor	CHEBI:35341	35540(Tax:7227)	Chemical	Gene	superfamily|amod|START_ENTITY member|nmod|superfamily END_ENTITY|appos|member	The Drosophila EcR gene encodes an ecdysone_receptor , a new member of the steroid receptor superfamily .
2119298	0	steroid	22,29	endothelin	174,184	steroid	endothelin	CHEBI:35341	1906	Chemical	Gene	START_ENTITY|nmod|mechanism mechanism|nmod|actin actin|nmod|END_ENTITY	Endothelin stimulates steroid secretion by frog adrenal gland in vitro : evidence for the involvement of prostaglandins and extracellular calcium in the mechanism of actin of endothelin .
19638349	0	steroid	22,29	endothelin-1	54,66	steroid	endothelin-1	CHEBI:35341	24323(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|gene gene|amod|END_ENTITY	Aldosterone modulates steroid receptor binding to the endothelin-1 gene -LRB- edn1 -RRB- .
12012272	0	steroid	43,50	epidermal_growth_factor	10,33	steroid	epidermal growth factor	CHEBI:35341	100008808(Tax:9986)	Chemical	Gene	MAP-kinase|amod|START_ENTITY Effect|nmod|MAP-kinase Effect|nmod|END_ENTITY	Effect of epidermal_growth_factor -LRB- EGF -RRB- on steroid and cyclic nucleotide secretion , proliferation and ERK-related MAP-kinase in cultured rabbit granulosa cells .
12390868	0	steroid	63,70	epidermal_growth_factor	14,37	steroid	epidermal growth factor	CHEBI:35341	13645(Tax:10090)	Chemical	Gene	biosynthesis|amod|START_ENTITY regulation|nmod|biosynthesis Mechanisms|dep|regulation Mechanisms|nmod|signaling signaling|compound|END_ENTITY	Mechanisms of epidermal_growth_factor signaling : regulation of steroid biosynthesis and the steroidogenic_acute_regulatory protein in mouse Leydig_tumor cells .
16288052	0	steroid	114,121	epidermal_growth_factor	31,54	steroid	epidermal growth factor	CHEBI:35341	13645(Tax:10090)	Chemical	Gene	antagonist|amod|START_ENTITY regulation|dep|antagonist regulation|nmod|END_ENTITY	Steroid receptor regulation of epidermal_growth_factor signaling through Src_in_breast_and_prostate_cancer cells : steroid antagonist action .
1770127	0	steroid	71,78	epidermal_growth_factor	34,57	steroid	epidermal growth factor	CHEBI:35341	1950	Chemical	Gene	hormones|amod|START_ENTITY Evidence|nmod|hormones Evidence|nmod|receptors receptors|compound|END_ENTITY	Evidence for direct regulation of epidermal_growth_factor receptors by steroid hormones in human endometrial cells .
2751256	0	steroid	46,53	epidermal_growth_factor	14,37	steroid	epidermal growth factor	CHEBI:35341	1950	Chemical	Gene	START_ENTITY|nsubj|Receptors Receptors|nmod|END_ENTITY	Receptors for epidermal_growth_factor and sex steroid hormones in human colorectal_carcinomas .
9379324	0	steroid	103,110	epidermal_growth_factor	15,38	steroid	epidermal growth factor	CHEBI:35341	1950	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|interleukin-1 interleukin-1|compound|END_ENTITY	The effects of epidermal_growth_factor , interleukin-1 , and phenytoin , alone and in combination , on C19 steroid conversions in fibroblasts .
1730720	0	steroid	33,40	estrogen_receptor	63,80	steroid	estrogen receptor	CHEBI:35341	2099	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	DNA allosterically modulates the steroid binding domain of the estrogen_receptor .
16614385	0	steroid	21,28	ferrochelatase	41,55	steroid	ferrochelatase	CHEBI:35341	101833515	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	The influence of sex steroid hormones on ferrochelatase gene expression in Harderian gland of hamster -LRB- Mesocricetus_auratus -RRB- .
8413314	0	steroid	8,15	follicle_stimulating_hormone_beta-subunit	54,95	steroid	follicle stimulating hormone beta-subunit	CHEBI:35341	14308(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|regulation regulation|nmod|expression expression|amod|END_ENTITY	Gonadal steroid hormone regulation of human and mouse follicle_stimulating_hormone_beta-subunit gene expression in vivo .
10748103	0	steroid	55,62	glucocorticoid_receptor	28,51	steroid	glucocorticoid receptor	CHEBI:35341	2908	Chemical	Gene	antagonists|amod|START_ENTITY END_ENTITY|nmod|antagonists	Selective activation of the glucocorticoid_receptor by steroid antagonists in human breast_cancer and osteosarcoma cells .
10825196	0	steroid	19,26	glucocorticoid_receptor	50,73	steroid	glucocorticoid receptor	CHEBI:35341	2908	Chemical	Gene	action|amod|START_ENTITY mechanism|nmod|action mechanism|nmod|monomers monomers|compound|END_ENTITY	Novel mechanism of steroid action in skin through glucocorticoid_receptor monomers .
10848625	0	steroid	98,105	glucocorticoid_receptor	61,84	steroid	glucocorticoid receptor	CHEBI:35341	2908	Chemical	Gene	START_ENTITY|nsubj|Interaction Interaction|nmod|domain domain|nmod|END_ENTITY	Interaction of the tau2 transcriptional activation domain of glucocorticoid_receptor with a novel steroid receptor coactivator , Hic-5 , which localizes to both focal adhesions and the nuclear matrix .
12871829	0	steroid	100,107	glucocorticoid_receptor	35,58	steroid	glucocorticoid receptor	CHEBI:35341	2908	Chemical	Gene	transporters|amod|START_ENTITY function|nmod|transporters function|compound|END_ENTITY	Antidepressant fluoxetine enhances glucocorticoid_receptor function in vitro by modulating membrane steroid transporters .
14619336	0	steroid	106,113	glucocorticoid_receptor	45,68	steroid	glucocorticoid receptor	CHEBI:35341	2908	Chemical	Gene	important|xcomp|START_ENTITY important|nsubj|affinity affinity|nmod|END_ENTITY	Decreased glucocorticoid binding affinity to glucocorticoid_receptor is important in the poor response to steroid therapy of older-aged patients with severe bronchial_asthma .
15883974	0	steroid	108,115	glucocorticoid_receptor	65,88	steroid	glucocorticoid receptor	CHEBI:35341	2908	Chemical	Gene	START_ENTITY|nsubj|basis basis|nmod|specificity specificity|nmod|END_ENTITY	Molecular basis of the interaction specificity between the human glucocorticoid_receptor and its endogenous steroid ligand cortisol .
16263717	0	steroid	109,116	glucocorticoid_receptor	141,164	steroid	glucocorticoid receptor	CHEBI:35341	2908	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|promoter promoter|compound|END_ENTITY	c-Myb and members of the c-Ets family of transcription factors act as molecular switches to mediate opposite steroid regulation of the human glucocorticoid_receptor 1A promoter .
21172202	0	steroid	47,54	glucocorticoid_receptor	77,100	steroid	glucocorticoid receptor	CHEBI:35341	2908	Chemical	Gene	START_ENTITY|dobj|levels levels|compound|END_ENTITY	Patients with ulcerative_colitis responding to steroid treatment up-regulate glucocorticoid_receptor levels in colorectal_mucosa .
22706020	0	steroid	9,16	glucocorticoid_receptor	37,60	steroid	glucocorticoid receptor	CHEBI:35341	2908	Chemical	Gene	START_ENTITY|dobj|response response|nmod|variant variant|compound|END_ENTITY	Enhanced steroid response of a human glucocorticoid_receptor splice variant .
23333190	0	steroid	44,51	glucocorticoid_receptor	96,119	steroid	glucocorticoid receptor	CHEBI:35341	2908	Chemical	Gene	impact|amod|START_ENTITY polymorphisms|nmod|impact nucleotide|iobj|polymorphisms nucleotide|dobj|response response|nmod|END_ENTITY	Single nucleotide polymorphisms and type of steroid impact the functional response of the human glucocorticoid_receptor .
23665916	0	steroid	104,111	glucocorticoid_receptor	65,88	steroid	glucocorticoid receptor	D013256	2908	Chemical	Gene	elements|amod|START_ENTITY facilitates|nmod|elements facilitates|dobj|recruitment recruitment|compound|END_ENTITY	C/EBP maintains chromatin accessibility in liver and facilitates glucocorticoid_receptor recruitment to steroid response elements .
25712143	0	steroid	68,75	glucocorticoid_receptor	18,41	steroid	glucocorticoid receptor	D013256	2908	Chemical	Gene	START_ENTITY|nsubj|abnormality abnormality|nmod|differentiates differentiates|compound|END_ENTITY	An abnormality in glucocorticoid_receptor expression differentiates steroid responders from nonresponders in keloid_disease .
26299668	0	steroid	184,191	glucocorticoid_receptor	114,137	steroid	glucocorticoid receptor	D013256	2908	Chemical	Gene	established|xcomp|START_ENTITY induced|parataxis|established induced|advcl|upregulating upregulating|dobj|UNASSIGNED UNASSIGNED|compound|END_ENTITY	Inhibition of microRNA -30 a prevents puromycin_aminonucleoside - induced podocytic apoptosis by upregulating the glucocorticoid_receptor a. UNASSIGNED : It is well - established that steroid - resistant nephrotic_syndrome commonly involves podocytic injury , however , the underlying mechanism remains to be elucidated .
2843290	0	steroid	57,64	glucocorticoid_receptor	87,110	steroid	glucocorticoid receptor	CHEBI:35341	2908	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	A movable and regulable inactivation function within the steroid binding domain of the glucocorticoid_receptor .
3335498	0	steroid	16,23	glucocorticoid_receptor	88,111	steroid	glucocorticoid receptor	CHEBI:35341	2908	Chemical	Gene	domain|amod|START_ENTITY region|nmod|domain determines|nsubj|region determines|dobj|formation formation|nmod|non-DNA-binding non-DNA-binding|appos|complex complex|compound|END_ENTITY	A region in the steroid binding domain determines formation of the non-DNA-binding , 9 S glucocorticoid_receptor complex .
3731065	0	steroid	123,130	glucocorticoid_receptor	9,32	steroid	glucocorticoid receptor	CHEBI:35341	2908	Chemical	Gene	responsiveness|amod|START_ENTITY effect|nmod|responsiveness lack|nmod|effect END_ENTITY|dep|lack	Elevated glucocorticoid_receptor binding in cultured human lymphoblasts following hydroxyurea treatment : lack of effect on steroid responsiveness .
3841006	0	steroid	46,53	glucocorticoid_receptor	22,45	steroid	glucocorticoid receptor	CHEBI:35341	2908	Chemical	Gene	START_ENTITY|nsubj|forms forms|nmod|END_ENTITY	Multiple forms of the glucocorticoid_receptor steroid binding protein identified by affinity labeling and high-resolution two-dimensional electrophoresis .
6590931	0	steroid	90,97	glucocorticoid_receptor	31,54	steroid	glucocorticoid receptor	CHEBI:35341	2908	Chemical	Gene	START_ENTITY|nsubj|relationship relationship|nmod|levels levels|compound|END_ENTITY	The relationship of blast cell glucocorticoid_receptor levels to response to single-agent steroid trial and remission response in children with acute_lymphoblastic_leukemia .
9830686	0	steroid	26,33	glucocorticoid_receptor	73,96	steroid	glucocorticoid receptor	CHEBI:35341	2908	Chemical	Gene	Iodinated|dep|START_ENTITY Iodinated|nsubj|3,2-c 3,2-c|acl|-RSB- -RSB-|nmod|agents agents|compound|END_ENTITY	Iodinated and fluorinated steroid 2 ' - aryl - -LSB- 3,2-c -RSB- _ pyrazoles as potential glucocorticoid_receptor imaging agents .
22506561	0	steroid	6,13	glucose_6-phosphate_dehydrogenase	28,61	steroid	glucose 6-phosphate dehydrogenase	CHEBI:35341	2539	Chemical	Gene	START_ENTITY|dobj|inhibitors inhibitors|nmod|END_ENTITY	Novel steroid inhibitors of glucose_6-phosphate_dehydrogenase .
1500848	0	steroid	80,87	gonadotrophin-releasing_hormone	11,42	steroid	gonadotrophin-releasing hormone	CHEBI:35341	2796	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of gonadotrophin-releasing_hormone , recombinant human activin-A and sex steroid hormones upon the follicle-stimulating isohormones secreted by rat anterior pituitary cells in culture .
3515349	0	steroid	63,70	gonadotropin-releasing_hormone	11,41	steroid	gonadotropin-releasing hormone	CHEBI:35341	25194(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|treatment treatment|amod|END_ENTITY	Effects of gonadotropin-releasing_hormone treatment on ovarian steroid production during midpregnancy .
8432780	0	steroid	35,42	gonadotropin-releasing_hormone	56,86	steroid	gonadotropin-releasing hormone	CHEBI:35341	2796	Chemical	Gene	START_ENTITY|nmod|agonist agonist|amod|END_ENTITY	Maturation of gonadotropin and sex steroid responses to gonadotropin-releasing_hormone agonist in males .
9355109	0	steroid	8,15	growth-associated_protein	30,55	steroid	growth-associated protein	CHEBI:35341	2596	Chemical	Gene	START_ENTITY|dobj|regulation regulation|nmod|expression expression|amod|END_ENTITY	Gonadal steroid regulation of growth-associated_protein GAP-43 mRNA expression in axotomized hamster facial motor neurons .
10527129	0	steroid	54,61	growth_hormone	25,39	steroid	growth hormone	CHEBI:35341	443329(Tax:9940)	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|END_ENTITY	The effects of exogenous growth_hormone on follicular steroid secretion and ovulation rate in sheep .
10813303	0	steroid	150,157	growth_hormone	57,71	steroid	growth hormone	CHEBI:35341	2688	Chemical	Gene	therapy|amod|START_ENTITY undergoing|dobj|therapy juvenile_chronic_arthritis|acl|undergoing recombinant|nmod|juvenile_chronic_arthritis recombinant|dobj|administration administration|compound|END_ENTITY	Effects on bone metabolism of one year recombinant human growth_hormone administration to children with juvenile_chronic_arthritis undergoing chronic steroid therapy .
11837503	0	steroid	81,88	growth_hormone	129,143	steroid	growth hormone	CHEBI:35341	2688	Chemical	Gene	therapy|amod|START_ENTITY requiring|dobj|therapy juvenile_idiopathic_arthritis|acl|requiring suffering|nmod|juvenile_idiopathic_arthritis children|acl|suffering growth|nmod|children growth|dep|history history|nmod|treatment treatment|amod|END_ENTITY	Linear growth in children suffering from juvenile_idiopathic_arthritis requiring steroid therapy : natural history and effects of growth_hormone treatment on linear growth .
12955028	0	steroid	38,45	growth_hormone	15,29	steroid	growth hormone	CHEBI:35341	2688	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|END_ENTITY	The effects of growth_hormone and sex steroid on lean body mass , fat mass , muscle strength , cardiovascular endurance and adverse events in healthy elderly women and men .
1352244	0	steroid	55,62	growth_hormone	77,91	steroid	growth hormone	CHEBI:35341	81668(Tax:10116)	Chemical	Gene	modulation|amod|START_ENTITY modulation|nmod|secretion secretion|amod|END_ENTITY	Basic counterpoint : mechanisms and pathways of gonadal steroid modulation of growth_hormone secretion .
14677197	0	steroid	124,131	growth_hormone	42,56	steroid	growth hormone	CHEBI:35341	2688	Chemical	Gene	therapy|amod|START_ENTITY requiring|dobj|therapy juvenile_idiopathic_arthritis|acl|requiring Effects|nmod|juvenile_idiopathic_arthritis Effects|nmod|treatment treatment|amod|END_ENTITY	Effects on growth and body composition of growth_hormone treatment in children with juvenile_idiopathic_arthritis requiring steroid therapy .
1537461	0	steroid	8,15	growth_hormone	90,104	steroid	growth hormone	CHEBI:35341	81668(Tax:10116)	Chemical	Gene	enzymes|amod|START_ENTITY controlled|nsubjpass|enzymes controlled|nmod|pattern pattern|nmod|secretion secretion|amod|END_ENTITY	Hepatic steroid hydroxylating enzymes are controlled by the sexually dimorphic pattern of growth_hormone secretion in normal and dwarf rats .
16061071	0	steroid	31,38	growth_hormone	80,94	steroid	growth hormone	CHEBI:35341	2688	Chemical	Gene	START_ENTITY|xcomp|encoding encoding|dobj|hormones hormones|amod|END_ENTITY	Effects of salmon GnRH and sex steroid hormones on expression of genes encoding growth_hormone / prolactin/somatolactin family hormones and a pituitary-specific transcription factor in masu salmon pituitary cells in vitro .
16125527	0	steroid	37,44	growth_hormone	11,25	steroid	growth hormone	CHEBI:35341	2688	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|sex sex|amod|END_ENTITY	Effects of growth_hormone and/or sex steroid administration on whole-body protein turnover in healthy aged women and men .
1618997	0	steroid	4,11	growth_hormone	31,45	steroid	growth hormone	CHEBI:35341	2688	Chemical	Gene	START_ENTITY|nmod|response response|amod|END_ENTITY	Sex steroid priming effects on growth_hormone response to pyridostigmine throughout the menstrual cycle .
21618141	0	steroid	28,35	growth_hormone	10,24	steroid	growth hormone	CHEBI:35341	378781(Tax:9031)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of growth_hormone on steroid content , proliferation and apoptosis in the chicken ovary during sexual maturation .
23329747	0	steroid	25,32	growth_hormone	44,58	steroid	growth hormone	CHEBI:35341	2688	Chemical	Gene	START_ENTITY|xcomp|priming priming|nmod|testing testing|amod|END_ENTITY	The pros and cons of sex steroid priming in growth_hormone stimulation testing .
2688653	0	steroid	91,98	growth_hormone	58,72	steroid	growth hormone	CHEBI:35341	81668(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY Interactions|nmod|metabolism Interactions|nmod|END_ENTITY	Interactions of insulin , thyroxine and dexamethasone with growth_hormone in the control of steroid metabolism by isolated rat hepatocytes .
2961786	0	steroid	109,116	growth_hormone	28,42	steroid	growth hormone	CHEBI:35341	2688	Chemical	Gene	START_ENTITY|nsubj|Changes Changes|nmod|END_ENTITY	Changes in growth and serum growth_hormone and plasma somatomedin-C levels during suppression of gonadal sex steroid secretion in girls with central precocious puberty .
3019741	0	steroid	127,134	growth_hormone	58,72	steroid	growth hormone	CHEBI:35341	81668(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY evidence|nmod|metabolism evidence|nmod|role role|nmod|END_ENTITY	Contradictory evidence concerning the `` universal '' role of growth_hormone in the regulation of the enzyme activities of hepatic steroid metabolism .
3546349	0	steroid	12,19	growth_hormone	51,65	steroid	growth hormone	CHEBI:35341	2688	Chemical	Gene	START_ENTITY|ccomp|mean mean|dobj|concentration concentration|compound|END_ENTITY	Chronic sex steroid exposure increases mean plasma growth_hormone concentration and pulse amplitude in men with isolated hypogonadotropic_hypogonadism .
4042968	0	steroid	65,72	growth_hormone	14,28	steroid	growth hormone	CHEBI:35341	81668(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Imprinting Imprinting|nmod|secretion secretion|amod|END_ENTITY	Imprinting of growth_hormone secretion , body growth , and hepatic steroid metabolism by neonatal testosterone .
5755725	0	steroid	41,48	growth_hormone	10,24	steroid	growth hormone	CHEBI:35341	81668(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of growth_hormone and an anabolic steroid on hydroxyproline in healing dermal wounds in rats .
5909247	1	steroid	35,42	growth_hormone	75,89	steroid	growth hormone	CHEBI:35341	2688	Chemical	Gene	hormones|amod|START_ENTITY effects|nmod|hormones effects|nmod|response response|compound|END_ENTITY	The effects of various steroid hormones on the insulin-induced growth_hormone response .
596447	0	steroid	77,84	growth_hormone	9,23	steroid	growth hormone	CHEBI:35341	443329(Tax:9940)	Chemical	Gene	hormones|amod|START_ENTITY relationship|nmod|hormones patterns|dep|relationship patterns|amod|END_ENTITY	Episodic growth_hormone secretory patterns in sheep : relationship to gonadal steroid hormones .
7227299	0	steroid	56,63	growth_hormone	23,37	steroid	growth hormone	CHEBI:35341	81668(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY feminizes|dobj|metabolism feminizes|nsubj|infusion infusion|nmod|END_ENTITY	Continuous infusion of growth_hormone feminizes hepatic steroid metabolism in the rat .
7593428	0	steroid	32,39	growth_hormone	88,102	steroid	growth hormone	CHEBI:35341	2688	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Differential impact of age , sex steroid hormones , and obesity on basal versus pulsatile growth_hormone secretion in men as assessed in an ultrasensitive chemiluminescence assay .
8690679	0	steroid	50,57	growth_hormone	71,85	steroid	growth hormone	CHEBI:35341	2688	Chemical	Gene	START_ENTITY|nmod|I I|amod|END_ENTITY	Effects of prenatal androgenization and postnatal steroid treatment on growth_hormone , insulin-like growth factor I and II , insulin , thyroxine , and triidothyronine concentrations in beef heifers .
8701783	0	steroid	66,73	growth_hormone	11,25	steroid	growth hormone	CHEBI:35341	2688	Chemical	Gene	synthesis|amod|START_ENTITY Effects|nmod|synthesis Effects|nmod|hormone hormone|amod|END_ENTITY	Effects of growth_hormone and growth_hormone-releasing hormone on steroid synthesis in cultured human luteinizing granulosa cells .
8742122	0	steroid	4,11	growth_hormone	26,40	steroid	growth hormone	CHEBI:35341	2688	Chemical	Gene	START_ENTITY|dobj|regulation regulation|nmod|secretion secretion|amod|END_ENTITY	Sex steroid regulation of growth_hormone secretion and action .
8818398	0	steroid	4,11	growth_hormone	62,76	steroid	growth hormone	CHEBI:35341	81668(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|development development|nmod|axis axis|amod|END_ENTITY	Sex steroid effects on the development and functioning of the growth_hormone axis .
9385529	0	steroid	84,91	growth_hormone	10,24	steroid	growth hormone	CHEBI:35341	2688	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|suppression suppression|amod|END_ENTITY	Effect of growth_hormone suppression on the serum levels of ovarian and adrenal sex steroid hormones in normal women and in women with polycystic_ovary_syndrome .
9467548	0	steroid	116,123	growth_hormone	31,45	steroid	growth hormone	CHEBI:35341	2688	Chemical	Gene	therapy|amod|START_ENTITY juvenile_chronic_arthritis|nmod|therapy children|nmod|juvenile_chronic_arthritis effects|nmod|children effects|nmod|administration administration|compound|END_ENTITY	Beneficial effects of one-year growth_hormone administration to children with juvenile_chronic_arthritis on chronic steroid therapy .
7902269	0	steroid	51,58	growth_hormone-releasing_hormone	123,155	steroid	growth hormone-releasing hormone	CHEBI:35341	29446(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|organization organization|nmod|END_ENTITY	Differential effects of the neonatal and adult sex steroid environments on the organization and activation of hypothalamic growth_hormone-releasing_hormone and somatostatin neurons .
7920984	0	steroid	28,35	growth_hormone-releasing_hormone	51,83	steroid	growth hormone-releasing hormone	CHEBI:35341	29446(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effects of the neonatal sex steroid environment on growth_hormone-releasing_hormone and somatostatin gene expression .
16726709	0	steroid	8,15	hCG	40,43	steroid	hCG	CHEBI:35341	3342	Chemical	Gene	START_ENTITY|nmod|stimulation stimulation|compound|END_ENTITY	Ovarian steroid secretion changes after hCG stimulation in early pregnant pigs .
19332066	0	steroid	27,34	hCG	11,14	steroid	hCG	CHEBI:35341	3342	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of hCG and ovarian steroid hormones on vasotocin levels in the female catfish Heteropneustes_fossilis .
6224978	0	steroid	20,27	hCG	63,66	steroid	hCG	CHEBI:35341	3342	Chemical	Gene	START_ENTITY|nmod|injection injection|nmod|END_ENTITY	Comparison of serum steroid responses to a single injection of hCG in man and rat .
7018892	0	steroid	14,21	hormone_receptor	22,38	steroid	hormone receptor	CHEBI:35341	3164	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Regulation of steroid hormone_receptor activity .
2307118	0	steroid	45,52	inhibin-alpha	107,120	steroid	inhibin-alpha	CHEBI:35341	24504(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY synthesis|nmod|END_ENTITY	The effects of sexual maturation and altered steroid synthesis on the production and route of secretion of inhibin-alpha from the rat testis .
10651224	0	steroid	78,85	intercellular_adhesion_molecule-1	29,62	steroid	intercellular adhesion molecule-1	CHEBI:35341	3383	Chemical	Gene	treatment|amod|START_ENTITY END_ENTITY|nmod|treatment	The changes of serum soluble intercellular_adhesion_molecule-1 after systemic steroid treatment in vitiligo .
9585104	0	steroid	47,54	interferon-alpha	27,43	steroid	interferon-alpha	CHEBI:35341	111654(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY Effect|nmod|production Effect|nmod|END_ENTITY	Effect of human and murine interferon-alpha on steroid production by rat ovarian cells .
17947510	0	steroid	26,33	interferon_regulatory_factor-1	90,120	steroid	interferon regulatory factor-1	CHEBI:35341	3659	Chemical	Gene	resistance|amod|START_ENTITY resistance|dep|role role|nmod|END_ENTITY	Cytokines induce an early steroid resistance in airway_smooth_muscle cells : novel role of interferon_regulatory_factor-1 .
9379324	0	steroid	103,110	interleukin-1	40,53	steroid	interleukin-1	CHEBI:35341	3552	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|END_ENTITY	The effects of epidermal_growth_factor , interleukin-1 , and phenytoin , alone and in combination , on C19 steroid conversions in fibroblasts .
15523430	0	steroid	109,116	interleukin-13	79,93	steroid	interleukin-13	CHEBI:35341	3596	Chemical	Gene	treatment|amod|START_ENTITY END_ENTITY|nmod|treatment	Alterations in eotaxin , monocyte_chemoattractant_protein-4 , interleukin-5 , and interleukin-13 after systemic steroid treatment for nasal_polyps .
11920401	0	steroid	33,40	interleukin-6	65,78	steroid	interleukin-6	CHEBI:35341	3569	Chemical	Gene	hormones|amod|START_ENTITY levels|nmod|hormones END_ENTITY|nsubj|levels	Inadequately low serum levels of steroid hormones in relation to interleukin-6 and tumor_necrosis_factor in untreated patients with early rheumatoid_arthritis and reactive_arthritis .
12468642	0	steroid	71,78	interleukin-6	12,25	steroid	interleukin-6	CHEBI:35341	3569	Chemical	Gene	hormones|amod|START_ENTITY directly|nmod|hormones regulated|nmod|directly regulated|nsubjpass|END_ENTITY	Endometrial interleukin-6 in vitro is not regulated directly by female steroid hormones , but by pro-inflammatory cytokines and hypoxia .
8803383	0	steroid	11,18	interleukin-6	37,50	steroid	interleukin-6	CHEBI:35341	3569	Chemical	Gene	START_ENTITY|dobj|levels levels|compound|END_ENTITY	Palliative steroid therapy and serum interleukin-6 levels in a patient with lung_cancer .
8929646	0	steroid	55,62	interleukin-6	27,40	steroid	interleukin-6	CHEBI:35341	3569	Chemical	Gene	therapy|amod|START_ENTITY suppressed|nmod|therapy suppressed|nsubj|localization localization|nmod|END_ENTITY	Glomerular localization of interleukin-6 suppressed by steroid mini-pulse therapy in an IgA_nephropathy patient .
9390345	0	steroid	86,93	interleukin-6	17,30	steroid	interleukin-6	CHEBI:35341	3569	Chemical	Gene	therapy|amod|START_ENTITY effect|nmod|therapy END_ENTITY|dep|effect	Increased plasma interleukin-6 in cutaneous plasmacytoma : the effect of intralesional steroid therapy .
10334915	0	steroid	36,43	leptin	73,79	steroid	leptin	CHEBI:35341	25608(Tax:10116)	Chemical	Gene	START_ENTITY|xcomp|milieu milieu|advcl|determining determining|dobj|concentrations concentrations|compound|END_ENTITY	A detailed study on the role of sex steroid milieu in determining plasma leptin concentrations in adult male and female rats .
10503725	0	steroid	54,61	leptin	14,20	steroid	leptin	CHEBI:35341	25608(Tax:10116)	Chemical	Gene	hormones|amod|START_ENTITY Regulation|nmod|hormones Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of leptin gene expression and secretion by steroid hormones .
10711727	0	steroid	75,82	leptin	30,36	steroid	leptin	CHEBI:35341	16846(Tax:10090)	Chemical	Gene	secretion|amod|START_ENTITY -LSB-|nmod|secretion -LSB-|nsubj|Effects Effects|nmod|END_ENTITY	Effects of recombinant murine leptin -LSB- 1-147 -RSB- and leptin fragment 116-130 on steroid secretion and proliferative activity of the regenerating rat adrenal cortex .
11154152	0	steroid	62,69	leptin	31,37	steroid	leptin	CHEBI:35341	3952	Chemical	Gene	Cord|xcomp|START_ENTITY Cord|dobj|END_ENTITY	Cord blood and postnatal serum leptin and its relationship to steroid use and growth in sick preterm infants .
12052243	0	steroid	184,191	leptin	11,17	steroid	leptin	CHEBI:35341	25608(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|administration administration|compound|END_ENTITY	Effects of leptin administration and feed restriction on thecal leucocytes in the preovulatory rat ovary and the effects of leptin on meiotic maturation , granulosa cell proliferation , steroid hormone and PGE2 release in cultured rat ovarian follicles .
12626035	0	steroid	15,22	leptin	55,61	steroid	leptin	CHEBI:35341	3952	Chemical	Gene	START_ENTITY|nmod|concentrations concentrations|compound|END_ENTITY	Effects of sex steroid hormones and menopause on serum leptin concentrations .
14654985	0	steroid	42,49	leptin	11,17	steroid	leptin	CHEBI:35341	25608(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY fragments|nmod|secretion fragments|nsubj|Effects Effects|nmod|END_ENTITY	Effects of leptin and leptin fragments on steroid secretion and proliferative activity of regenerating rat adrenal cortex .
14698207	0	steroid	42,49	leptin	11,17	steroid	leptin	CHEBI:35341	25608(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY fragments|nmod|secretion fragments|nsubj|Effects Effects|nmod|END_ENTITY	Effects of leptin and leptin fragments on steroid secretion of freshly dispersed rat adrenocortical cells .
15653206	0	steroid	62,69	leptin	43,49	steroid	leptin	CHEBI:35341	3952	Chemical	Gene	START_ENTITY|nsubj|relation relation|nmod|END_ENTITY	The relation of serum and follicular fluid leptin and ovarian steroid levels in response to induction of ovulation in in_vitro_fertilization cycles .
16359988	0	steroid	4,11	leptin	59,65	steroid	leptin	CHEBI:35341	3952	Chemical	Gene	milieu|amod|START_ENTITY Sex|amod|milieu alter|nsubj|Sex alter|dobj|impact impact|acl|fasting fasting|nmod|levels levels|compound|END_ENTITY	Sex steroid milieu does not alter the impact of fasting on leptin levels in women .
9449213	0	steroid	40,47	leptin	30,36	steroid	leptin	CHEBI:35341	16846(Tax:10090)	Chemical	Gene	secretion|amod|START_ENTITY END_ENTITY|nmod|secretion	Effects of recombinant murine leptin on steroid secretion of dispersed rat adrenocortical cells .
9543124	0	steroid	37,44	leptin	66,72	steroid	leptin	CHEBI:35341	3952	Chemical	Gene	START_ENTITY|nmod|concentrations concentrations|compound|END_ENTITY	The impact of reversible gonadal sex steroid suppression on serum leptin concentrations in children with central precocious puberty .
7980630	0	steroid	37,44	lipocortin_1	13,25	steroid	lipocortin 1	CHEBI:35341	25380(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Induction Induction|nmod|END_ENTITY	Induction of lipocortin_1 by topical steroid in rat skin .
9030826	0	steroid	17,24	lipoprotein_lipase	39,57	steroid	lipoprotein lipase	CHEBI:35341	4023	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Evidence for sex steroid inhibition of lipoprotein_lipase in men : comparison of abdominal and femoral adipose tissue .
24424068	0	steroid	214,221	mPRa	96,100	steroid	mPRa	CHEBI:35341	20200(Tax:10090)	Chemical	Gene	receptors|amod|START_ENTITY END_ENTITY|nmod|receptors	Enhancement of cell surface expression and receptor functions of membrane progestin receptor a -LRB- mPRa -RRB- by progesterone_receptor membrane component 1 -LRB- PGRMC1 -RRB- : evidence for a role of PGRMC1 as an adaptor protein for steroid receptors .
20096719	0	steroid	19,26	mPRalpha	76,84	steroid	mPRalpha	CHEBI:35341	20200(Tax:10090)	Chemical	Gene	alpha|amod|START_ENTITY alpha|appos|END_ENTITY	Comparison between steroid binding to membrane progesterone receptor alpha -LRB- mPRalpha -RRB- and to nuclear_progesterone_receptor : correlation with physicochemical properties assessed by comparative molecular field analysis and identification of mPRalpha-specific agonists .
24062630	0	steroid	23,30	mechano-growth_factor	90,111	steroid	mechano-growth factor	CHEBI:35341	60427(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	The effect of anabolic steroid administration on passive stretching-induced expression of mechano-growth_factor in skeletal muscle .
9645683	0	steroid	8,15	neurotrophic_factor	30,49	steroid	neurotrophic factor	CHEBI:35341	81737(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|regulation regulation|nmod|expression expression|compound|END_ENTITY	Adrenal steroid regulation of neurotrophic_factor expression in the rat hippocampus .
1645447	4	steroid	604,611	nur77	578,583	steroid	Nur77	CHEBI:35341	79240(Tax:10116)	Chemical	Gene	superfamily|amod|START_ENTITY member|nmod|superfamily member|nsubj|gene gene|appos|END_ENTITY	One such gene , nur77 , is a member of the steroid and thyroid hormone receptor gene superfamily .
9548563	0	steroid	19,26	osteocalcin	56,67	steroid	osteocalcin	CHEBI:35341	81613(Tax:10116)	Chemical	Gene	control|amod|START_ENTITY control|nmod|END_ENTITY	Multiple levels of steroid hormone-dependent control of osteocalcin during osteoblast differentiation : glucocorticoid regulation of basal and vitamin_D stimulated gene expression .
2328690	0	steroid	32,39	oxytocin	11,19	steroid	oxytocin	CHEBI:35341	5020	Chemical	Gene	release|amod|START_ENTITY Effects|nmod|release Effects|nmod|END_ENTITY	Effects of oxytocin on in vitro steroid release of midstage small and large porcine luteal cells .
3359963	0	steroid	49,56	oxytocin	21,29	steroid	oxytocin	CHEBI:35341	100152272(Tax:9823)	Chemical	Gene	release|amod|START_ENTITY effect|nmod|release effect|nmod|END_ENTITY	Inhibitory effect of oxytocin and vasopressin on steroid release by cultured porcine luteal cells .
14658589	1	steroid	142,149	p53	137,140	steroid	p53	CHEBI:35341	7157	Chemical	Gene	status|amod|START_ENTITY status|compound|END_ENTITY	An immunohistochemical study including correlations with p53 , steroid receptor status and proliferative indices -LRB- PCNA , MIB1 -RRB- .
15274338	1	steroid	114,121	p53	109,112	steroid	p53	CHEBI:35341	7157	Chemical	Gene	START_ENTITY|dep|Correlation Correlation|nmod|END_ENTITY	Correlation with p53 , steroid receptor status , proliferative indices -LRB- PCNA , MIB1 -RRB- and survival .
10080679	0	steroid	42,49	pS2	0,3	steroid	pS2	CHEBI:35341	338412	Chemical	Gene	status|amod|START_ENTITY association|nmod|status END_ENTITY|dep|association	pS2 in breast_carcinoma : association with steroid hormone receptor status .
10522772	0	steroid	72,79	pS2	33,36	steroid	pS2	CHEBI:35341	338412	Chemical	Gene	receptors|amod|START_ENTITY correlation|nmod|receptors measurement|dep|correlation measurement|nmod|END_ENTITY	Immunoradiometric measurement of pS2 in breast_cancer -- correlation with steroid receptors and plasminogen activators .
1515241	0	steroid	55,62	pS2	24,27	steroid	pS2	CHEBI:35341	338412	Chemical	Gene	status|amod|START_ENTITY relevance|nmod|status relevance|nmod|status status|amod|END_ENTITY	Prognostic relevance of pS2 status in association with steroid receptor status and proliferative activity in node-negative breast_cancer .
19132993	0	steroid	62,69	pS2	0,3	steroid	pS2	CHEBI:35341	7031	Chemical	Gene	status|amod|START_ENTITY correlation|nmod|status expression|dep|correlation expression|amod|END_ENTITY	pS2 -LRB- TFF1 -RRB- expression in prostate_carcinoma : correlation with steroid receptor status .
8123486	0	steroid	115,122	pS2	31,34	steroid	pS2	CHEBI:35341	338412	Chemical	Gene	receptors|amod|START_ENTITY correlation|nmod|receptors detection|dep|correlation detection|nmod|cathepsin_D cathepsin_D|amod|END_ENTITY	Immunoradiometric detection of pS2 and total cathepsin_D in primary breast_cancer biopsies : their correlation with steroid receptors .
9699519	0	steroid	10,17	pS2	29,32	steroid	pS2	CHEBI:35341	338412	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Effect of steroid receptors , pS2 and cathepsin_D on the outcome of elderly breast_cancer patients : an exploratory investigation .
20032461	0	steroid	11,18	peroxisome_proliferator-activated_receptor_alpha	44,92	steroid	peroxisome proliferator-activated receptor alpha	CHEBI:35341	19013(Tax:10090)	Chemical	Gene	synthesis|amod|START_ENTITY synthesis|nmod|END_ENTITY	Control of steroid 21-oic acid synthesis by peroxisome_proliferator-activated_receptor_alpha and role of the hypothalamic-pituitary-adrenal_axis .
15967160	0	steroid	21,28	platelet-activating_factor_receptor	79,114	steroid	platelet-activating factor receptor	CHEBI:35341	518283(Tax:9913)	Chemical	Gene	START_ENTITY|nmod|mRNA mRNA|nmod|END_ENTITY	Influence of ovarian steroid hormones or platelet-activating factor on mRNA of platelet-activating_factor_receptor in endometrial explant perfusion cultures from ovariectomized bovine .
1420166	0	steroid	15,22	progesterone_receptor	69,90	steroid	progesterone receptor	CHEBI:35341	5241	Chemical	Gene	RU486|amod|START_ENTITY Effects|nmod|RU486 Effects|nmod|END_ENTITY	Effects of the steroid antagonist RU486 on dimerization of the human progesterone_receptor .
1595890	0	steroid	89,96	progesterone_receptor	181,202	steroid	progesterone receptor	CHEBI:35341	5241	Chemical	Gene	superfamily|amod|START_ENTITY superfamily|dep|isolation isolation|nmod|domain domain|amod|progesterone progesterone|nmod|plasma plasma|acl|using using|dobj|END_ENTITY	A method for characterization of endogenous ligands to orphan receptors belonging to the steroid hormone receptor superfamily -- isolation of progesterone from pregnancy plasma using progesterone_receptor ligand-binding domain .
21854761	0	steroid	34,41	progesterone_receptor	84,105	steroid	progesterone receptor	CHEBI:35341	5241	Chemical	Gene	antagonism|amod|START_ENTITY mechanism|nmod|antagonism Discovery|nmod|mechanism Discovery|dep|END_ENTITY	Discovery of a novel mechanism of steroid receptor antagonism : WAY-255348 modulates progesterone_receptor cellular localization and promoter interactions .
2703171	0	steroid	14,21	progesterone_receptor	102,123	steroid	progesterone receptor	CHEBI:35341	5241	Chemical	Gene	receptors|amod|START_ENTITY Importance|nmod|receptors Importance|parataxis|correlate correlate|nsubj|levels levels|compound|END_ENTITY	Importance of steroid receptors and aromatase activity in the prognosis of ovarian_cancer : high tumor progesterone_receptor levels correlate with longer survival .
6748653	0	steroid	56,63	progesterone_receptor	31,52	steroid	progesterone receptor	CHEBI:35341	396198(Tax:9031)	Chemical	Gene	resins|amod|START_ENTITY END_ENTITY|nmod|resins	Binding of the chicken oviduct progesterone_receptor to steroid affinity resins : resistance to elution with mercurial reagents .
8504742	0	steroid	137,144	progesterone_receptor	14,35	steroid	progesterone receptor	CHEBI:35341	25154(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of progesterone_receptor gene expression and growth in the rat uterus : modulation of estrogen actions by progesterone and sex steroid hormone antagonists .
8609903	0	steroid	8,15	progesterone_receptor	48,69	steroid	progesterone receptor	CHEBI:35341	5241	Chemical	Gene	START_ENTITY|dobj|specificity specificity|nmod|END_ENTITY	Unusual steroid specificity of the cell surface progesterone_receptor on human sperm .
8873123	0	steroid	59,66	progesterone_receptor	14,35	steroid	progesterone receptor	CHEBI:35341	100009094(Tax:9986)	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of progesterone_receptor gene expression by sex steroid hormones in the hypothalamus and the cerebral cortex of the rabbit .
9614359	0	steroid	102,109	progesterone_receptor	11,32	steroid	progesterone receptor	CHEBI:35341	100009094(Tax:9986)	Chemical	Gene	START_ENTITY|nsubj|Changes Changes|nmod|content content|compound|END_ENTITY	Changes in progesterone_receptor mRNA content in the rabbit lung during early pregnancy and after sex steroid hormone treatment .
1165627	0	steroid	54,61	proinsulin	13,23	steroid	proinsulin	CHEBI:35341	3630	Chemical	Gene	administration|amod|START_ENTITY secretion|nmod|administration secretion|compound|END_ENTITY	-LSB- Insulin and proinsulin secretion under contraceptive steroid administration -LRB- author 's transl -RRB- -RSB- .
1407378	0	steroid	48,55	prolactin	13,22	steroid	prolactin	CHEBI:35341	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Abolition Abolition|nmod|surge surge|compound|END_ENTITY	Abolition of prolactin surge induced by ovarian steroid hormones in the lactating rat .
1502928	0	steroid	24,31	prolactin	53,62	steroid	prolactin	CHEBI:35341	5617	Chemical	Gene	START_ENTITY|nmod|concentrations concentrations|compound|END_ENTITY	Effects of cross-gender steroid hormone treatment on prolactin concentrations in humans .
16420345	0	steroid	30,37	prolactin	48,57	steroid	prolactin	CHEBI:35341	5617	Chemical	Gene	hormones|amod|START_ENTITY assays|nmod|hormones assays|amod|END_ENTITY	Reproducibility of assays for steroid hormones , prolactin and insulin-like_growth_factor-1 in umbilical cord blood .
17519522	0	steroid	39,46	prolactin	18,27	steroid	prolactin	CHEBI:35341	24683(Tax:10116)	Chemical	Gene	release|amod|START_ENTITY END_ENTITY|nmod|release	Direct effects of prolactin on adrenal steroid release in male Hatano high-avoidance -LRB- HAA -RRB- rats may be mediated through Janus_kinase_2 -LRB- Jak2 -RRB- activity .
2946606	0	steroid	121,128	prolactin	53,62	steroid	prolactin	CHEBI:35341	5617	Chemical	Gene	START_ENTITY|nsubj|changes changes|nmod|concentrations concentrations|nmod|END_ENTITY	Time-related changes in the plasma concentrations of prolactin , gonadotropins , sex_hormone-binding_globulin , and certain steroid hormones in female runners after a long-distance race .
2987289	0	steroid	77,84	prolactin	23,32	steroid	prolactin	CHEBI:35341	5617	Chemical	Gene	hormones|amod|START_ENTITY binding|nmod|hormones binding|nsubj|modulation modulation|nmod|END_ENTITY	In vitro modulation of prolactin binding to human mammary_carcinoma cells by steroid hormones and prolactin .
3124157	0	steroid	61,68	prolactin	14,23	steroid	prolactin	CHEBI:35341	24683(Tax:10116)	Chemical	Gene	priming|amod|START_ENTITY roles|nmod|priming Regulation|dep|roles Regulation|nmod|secretion secretion|compound|END_ENTITY	Regulation of prolactin secretion in parental rats : roles of steroid priming and pituitary responsiveness .
3324676	0	steroid	91,98	prolactin	8,17	steroid	prolactin	CHEBI:35341	5617	Chemical	Gene	feedback|amod|START_ENTITY system|nmod|feedback Role|nmod|system Role|nmod|END_ENTITY	Role of prolactin in the regulation of sensitivity of the hypothalamic-pituitary system to steroid feedback .
354298	0	steroid	48,55	prolactin	25,34	steroid	prolactin	CHEBI:35341	5617	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|cimetidine cimetidine|nmod|END_ENTITY	Effects of cimetidine on prolactin , LH , and sex steroid secretion in male and female volunteers .
3822078	0	steroid	25,32	prolactin	62,71	steroid	prolactin	CHEBI:35341	24683(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY treatment|dep|effects effects|nmod|catecholamines catecholamines|compound|sexual_behavior sexual_behavior|compound|END_ENTITY	Long-term weekly gonadal steroid treatment : effects on plasma prolactin , sexual_behavior and hypothalamic-preoptic area catecholamines .
6790134	0	steroid	30,37	prolactin	50,59	steroid	prolactin	CHEBI:35341	396453(Tax:9031)	Chemical	Gene	START_ENTITY|nmod|concentrations concentrations|compound|END_ENTITY	Effects of ageing and gonadal steroid hormones on prolactin concentrations in the anterior pituitary of the chicken .
6807580	0	steroid	144,151	prolactin	16,25	steroid	prolactin	CHEBI:35341	5617	Chemical	Gene	exposure|compound|START_ENTITY relationship|nmod|exposure response|dep|relationship response|nmod|END_ENTITY	The response of prolactin to chlorpromazine stimulation in men with hypogonadotrophic_hypogonadism and early pubertal boys : relationship to sex steroid exposure .
6833935	0	steroid	24,31	prolactin	11,20	steroid	prolactin	CHEBI:35341	5617	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of prolactin on steroid production by human luteal cells in vitro .
6933996	0	steroid	120,127	prolactin	29,38	steroid	prolactin	CHEBI:35341	24683(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY activities|nmod|metabolism differentiated|dobj|activities differentiated|nsubj|Influence Influence|nmod|drugs drugs|acl|affecting affecting|dobj|secretion secretion|compound|END_ENTITY	Influence of drugs affecting prolactin secretion on some sexually differentiated hepatic and renal enzyme activities of steroid hormone metabolism in the rat .
760259	0	steroid	14,21	prolactin	44,53	steroid	prolactin	CHEBI:35341	5617	Chemical	Gene	START_ENTITY|nmod|concentration concentration|compound|END_ENTITY	Effect of sex steroid hormones on the serum prolactin concentration .
8006337	0	steroid	109,116	prolactin	16,25	steroid	prolactin	CHEBI:35341	5617	Chemical	Gene	levels|amod|START_ENTITY independent|nmod|levels independent|nsubj|duration duration|nmod|bursts bursts|amod|END_ENTITY	The duration of prolactin secretory bursts from the pituitary is independent from both prolactin and gonadal steroid plasma levels in women and in men .
8006337	0	steroid	109,116	prolactin	87,96	steroid	prolactin	CHEBI:35341	5617	Chemical	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	The duration of prolactin secretory bursts from the pituitary is independent from both prolactin and gonadal steroid plasma levels in women and in men .
9208405	0	steroid	19,26	prolactin	59,68	steroid	prolactin	CHEBI:35341	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|responses responses|compound|END_ENTITY	Effects of ovarian steroid hormones on dopamine-controlled prolactin secretory responses in vitro .
10194526	0	steroid	23,30	prolactin_receptor	62,80	steroid	prolactin receptor	CHEBI:35341	19116(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Involvement of gonadal steroid hormone disturbance in altered prolactin_receptor gene expression in the liver of diabetic mice .
15956338	0	steroid	28,35	prolactin_receptor	119,137	steroid	prolactin receptor	CHEBI:35341	24684(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|exons exons|nmod|exon exon|nmod|gene gene|compound|END_ENTITY	Differential effects of sex steroid hormones on the expression of multiple first exons including a novel first exon of prolactin_receptor gene in the rat liver .
9360527	0	steroid	68,75	prolactin_receptor	41,59	steroid	prolactin receptor	CHEBI:35341	5618	Chemical	Gene	START_ENTITY|nsubj|Coexpression Coexpression|nmod|END_ENTITY	Coexpression and cross-regulation of the prolactin_receptor and sex steroid hormone receptors in breast_cancer .
8538866	0	steroid	8,15	proopiomelanocortin	38,57	steroid	proopiomelanocortin	CHEBI:35341	24664(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|regulation regulation|nmod|expression expression|compound|END_ENTITY	Gonadal steroid hormone regulation of proopiomelanocortin gene expression in arcuate neurons that innervate the medial preoptic area of the rat .
9131666	0	steroid	8,15	proopiomelanocortin	38,57	steroid	proopiomelanocortin	CHEBI:35341	24664(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|regulation regulation|nmod|expression expression|amod|END_ENTITY	Gonadal steroid hormone regulation of proopiomelanocortin gene expression in neurons that innervate the median eminence of the rat .
1580447	0	steroid	14,21	retinol-binding_protein	88,111	steroid	retinol-binding protein	CHEBI:35341	5950	Chemical	Gene	Prediction|nmod|START_ENTITY responsiveness|nsubj|Prediction responsiveness|nmod|nephrotic_syndrome nephrotic_syndrome|acl|using using|xcomp|END_ENTITY	Prediction of steroid responsiveness in the idiopathic nephrotic_syndrome using urinary retinol-binding_protein and beta-2-microglobulin .
1510947	0	steroid	74,81	sex_hormone_binding_globulin	98,126	steroid	sex hormone binding globulin	CHEBI:35341	6462	Chemical	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Characterization of Met-139 as the photolabeled amino_acid residue in the steroid binding site of sex_hormone_binding_globulin using delta 6 derivatives of either testosterone or estradiol as unsubstituted photoaffinity labeling reagents .
24739643	0	steroid	97,104	stromal_cell-derived_factor-1	15,44	steroid	stromal cell-derived factor-1	CHEBI:35341	20315(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	-LSB- Expression of stromal_cell-derived_factor-1 in endometriosis by steroid_receptor_coactivatorson steroid hormone -RSB- .
11070353	0	steroid	7,14	sulfatase	15,24	steroid	sulfatase	CHEBI:35341	24800(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|levels levels|amod|END_ENTITY	Tissue steroid sulfatase levels , testosterone and blood pressure .
12796397	0	steroid	19,26	sulfatase	27,36	steroid	sulfatase	CHEBI:35341	347527	Chemical	Gene	mRNA|amod|START_ENTITY mRNA|compound|END_ENTITY	High expression of steroid sulfatase mRNA predicts poor prognosis in patients with estrogen_receptor-positive_breast_cancer .
12814632	0	steroid	42,49	sulfatase	50,59	steroid	sulfatase	CHEBI:35341	347527	Chemical	Gene	assay|nmod|START_ENTITY END_ENTITY|nsubj|assay	Microtiter plate cellular assay for human steroid sulfatase with fluorescence readout .
14672734	0	steroid	21,28	sulfatase	29,38	steroid	sulfatase	CHEBI:35341	24800(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|inhibitors inhibitors|amod|END_ENTITY	Development of novel steroid sulfatase inhibitors .
14684318	0	steroid	106,113	sulfatase	114,123	steroid	sulfatase	CHEBI:35341	347527	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	The difluoromethylene group as a replacement for the labile oxygen in steroid sulfates : a new approach to steroid sulfatase inhibitors .
14684318	0	steroid	70,77	sulfatase	114,123	steroid	sulfatase	CHEBI:35341	347527	Chemical	Gene	sulfates|amod|START_ENTITY oxygen|nmod|sulfates replacement|nmod|oxygen group|nmod|replacement group|dep|approach approach|nmod|inhibitors inhibitors|compound|END_ENTITY	The difluoromethylene group as a replacement for the labile oxygen in steroid sulfates : a new approach to steroid sulfatase inhibitors .
15084348	0	steroid	21,28	sulfatase	29,38	steroid	sulfatase	CHEBI:35341	24800(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|inhibitors inhibitors|amod|END_ENTITY	Development of novel steroid sulfatase inhibitors ; II .
15544928	0	steroid	57,64	sulfatase	65,74	steroid	sulfatase	CHEBI:35341	347527	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	6 - -LSB- 2 - -LRB- adamantylidene -RRB- - hydroxybenzoxazole -RSB- - O-sulfamate , a steroid sulfatase inhibitor for the treatment of androgen - and estrogen-dependent diseases .
1606923	0	steroid	31,38	sulfatase	39,48	steroid	sulfatase	CHEBI:35341	347527	Chemical	Gene	Purification|nmod|START_ENTITY END_ENTITY|nsubj|Purification	Purification and properties of steroid sulfatase from human placenta .
16533785	0	steroid	86,93	sulfatase	94,103	steroid	sulfatase	CHEBI:35341	347527	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	Phase I study of STX 64 -LRB- 667 Coumate -RRB- in breast_cancer patients : the first study of a steroid sulfatase inhibitor .
17914670	0	steroid	25,32	sulfatase	33,42	steroid	sulfatase	CHEBI:35341	20905(Tax:10090)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Efficacy of three potent steroid sulfatase inhibitors : pre-clinical investigations for their use in the treatment of hormone-dependent breast_cancer .
18816537	0	steroid	53,60	sulfatase	61,70	steroid	sulfatase	CHEBI:35341	347527	Chemical	Gene	START_ENTITY|dobj|inhibitors inhibitors|amod|END_ENTITY	Synthesis of aromatase inhibitors and dual aromatase steroid sulfatase inhibitors by linking an arylsulfamate motif to 4 - -LRB- 4H-1 ,2,4 - triazol-4-ylamino -RRB- benzonitrile : SAR , crystal structures , in vitro and in vivo activities .
19418464	0	steroid	25,32	sulfatase	66,75	steroid	sulfatase	CHEBI:35341	347527	Chemical	Gene	START_ENTITY|advcl|identify identify|dobj|deficiency deficiency|compound|END_ENTITY	Maternal urine and serum steroid measurements to identify steroid sulfatase deficiency -LRB- STSD -RRB- in second trimester pregnancies .
19418464	0	steroid	58,65	sulfatase	66,75	steroid	sulfatase	CHEBI:35341	347527	Chemical	Gene	deficiency|amod|START_ENTITY deficiency|compound|END_ENTITY	Maternal urine and serum steroid measurements to identify steroid sulfatase deficiency -LRB- STSD -RRB- in second trimester pregnancies .
20715120	0	steroid	14,21	sulfatase	22,31	steroid	sulfatase	CHEBI:35341	347527	Chemical	Gene	Prevalence|nmod|START_ENTITY END_ENTITY|nsubj|Prevalence	Prevalence of steroid sulfatase deficiency in California according to race and ethnicity .
21925885	0	steroid	14,21	sulfatase	22,31	steroid	sulfatase	CHEBI:35341	347527	Chemical	Gene	Inhibition|nmod|START_ENTITY END_ENTITY|nsubj|Inhibition	Inhibition of steroid sulfatase with 4-substituted_estrone and estradiol derivatives .
22419362	0	steroid	53,60	sulfatase	61,70	steroid	sulfatase	CHEBI:35341	347527	Chemical	Gene	deficiency-x-linked_recessive_ichthyosis|amod|START_ENTITY deficiency-x-linked_recessive_ichthyosis|compound|END_ENTITY	Steroid-resistant nephrotic_syndrome associated with steroid sulfatase deficiency-x-linked_recessive_ichthyosis : a case report and review of literature .
22475435	0	steroid	5,12	sulfatase	13,22	steroid	sulfatase	CHEBI:35341	347527	Chemical	Gene	deficiency|amod|START_ENTITY deficiency|compound|END_ENTITY	Does steroid sulfatase deficiency influence postpartum psychosis risk ?
22486328	0	steroid	121,128	sulfatase	129,138	steroid	sulfatase	CHEBI:35341	347527	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Proton-in-flight mechanism for the spontaneous hydrolysis of N-methyl_O-phenyl_sulfamate : implications for the design of steroid sulfatase inhibitors .
2953750	0	steroid	8,15	sulfatase	16,25	steroid	sulfatase	CHEBI:35341	347527	Chemical	Gene	START_ENTITY|dobj|activity activity|amod|END_ENTITY	In situ steroid sulfatase activity in human epithelial_carcinoma cells of vaginal , ovarian , and endometrial origin .
2965775	0	steroid	42,49	sulfatase	50,59	steroid	sulfatase	CHEBI:35341	347527	Chemical	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Effects of estrogen and growth_hormone on steroid sulfatase activity and estrogen binding in rat liver .
3165268	0	steroid	27,34	sulfatase	35,44	steroid	sulfatase	CHEBI:35341	347527	Chemical	Gene	Synthesis|nmod|START_ENTITY END_ENTITY|nsubj|Synthesis	Synthesis and stability of steroid sulfatase in fibroblasts from multiple_sulfatase_deficiency .
3462435	0	steroid	45,52	sulfatase	53,62	steroid	sulfatase	CHEBI:35341	347527	Chemical	Gene	deficiency|amod|START_ENTITY deficiency|compound|END_ENTITY	Regulation of serum testosterone in men with steroid sulfatase deficiency : response to human chorionic gonadotropin .
3531932	0	steroid	65,72	sulfatase	73,82	steroid	sulfatase	CHEBI:35341	347527	Chemical	Gene	deficiency|amod|START_ENTITY deficiency|compound|END_ENTITY	Placental_sulfatase_deficiency : maternal and fetal expression of steroid sulfatase deficiency and X-linked_ichthyosis .
7547880	0	steroid	16,23	sulfatase	24,33	steroid	sulfatase	CHEBI:35341	347527	Chemical	Gene	Inactivation|nmod|START_ENTITY END_ENTITY|nsubj|Inactivation	Inactivation of steroid sulfatase by an active site-directed inhibitor , estrone-3-O-sulfamate .
8059846	0	steroid	9,16	sulfatase	17,26	steroid	sulfatase	CHEBI:35341	347527	Chemical	Gene	deficiency|amod|START_ENTITY deficiency|compound|END_ENTITY	Maternal steroid sulfatase deficiency -- cause of high-risk pregnancy ?
9247725	0	steroid	27,34	sulfatase	35,44	steroid	sulfatase	CHEBI:35341	347527	Chemical	Gene	deletion|nmod|START_ENTITY Diagnosis|nmod|deletion END_ENTITY|nsubj|Diagnosis	Diagnosis of a deletion of steroid sulfatase by polymerase chain reaction and high-performance liquid chromatography .
9252398	1	steroid	119,126	sulfatase	127,136	steroid	sulfatase	CHEBI:35341	347527	Chemical	Gene	protein|amod|START_ENTITY protein|compound|END_ENTITY	Effects on the structure and function of the steroid sulfatase protein .
12711022	0	steroid	65,72	sulphatase	73,83	steroid	sulphatase	CHEBI:35341	412	Chemical	Gene	START_ENTITY|dobj|activity activity|amod|END_ENTITY	Inhibition of MCF-7 breast_cancer cell proliferation and in vivo steroid sulphatase activity by 2-methoxyoestradiol-bis-sulphamate .
9886847	0	steroid	61,68	thioredoxin	13,24	steroid	thioredoxin	CHEBI:35341	7295	Chemical	Gene	START_ENTITY|nsubj|Induction Induction|nmod|END_ENTITY	Induction of thioredoxin , a redox-active protein , by ovarian steroid hormones during growth and differentiation of endometrial stromal cells in vitro .
23035734	0	steroid	110,117	transforming_growth_factor-b	67,95	steroid	transforming growth factor-b	CHEBI:35341	7040	Chemical	Gene	receptors|amod|START_ENTITY END_ENTITY|dep|receptors	Signal transduction pathway analysis in desmoid-type_fibromatosis : transforming_growth_factor-b , COX2 and sex steroid receptors .
8206321	0	steroid	66,73	transforming_growth_factor-beta	11,42	steroid	transforming growth factor-beta	CHEBI:35341	7040	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of transforming_growth_factor-beta on human fetal adrenal steroid production .
8824338	0	steroid	8,15	tryptophan_hydroxylase	30,52	steroid	tryptophan hydroxylase	CHEBI:35341	695363(Tax:9544)	Chemical	Gene	START_ENTITY|dobj|regulation regulation|nmod|expression expression|amod|END_ENTITY	Ovarian steroid regulation of tryptophan_hydroxylase mRNA expression in rhesus_macaques .
19696011	0	steroid	47,54	vascular_endothelial_growth_factor	69,103	steroid	vascular endothelial growth factor	CHEBI:35341	83785(Tax:10116)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Effects of neonatal exposure to bisphenol_A on steroid regulation of vascular_endothelial_growth_factor expression and endothelial cell proliferation in the adult rat uterus .
9447459	0	steroid	40,47	vascular_endothelial_growth_factor	131,165	steroid	vascular endothelial growth factor	CHEBI:35341	7422	Chemical	Gene	production|amod|START_ENTITY correlate|nsubj|production correlate|nmod|expression expression|nmod|END_ENTITY	In controlled ovarian_hyperstimulation , steroid production , oocyte retrieval , and pregnancy rate correlate with gene expression of vascular_endothelial_growth_factor .
810580	0	steroid	10,17	vasopressin	63,74	steroid	vasopressin	CHEBI:35341	551	Chemical	Gene	depletion|amod|START_ENTITY Effect|nmod|depletion Effect|nmod|END_ENTITY	Effect of steroid depletion on the response of toad bladder to vasopressin .
6239494	0	steroid-sulphate	59,75	phospholipase_A2	30,46	steroid-sulphate	phospholipase A2	null	151056	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Enhancement of human amniotic phospholipase_A2 activity by steroid-sulphate derived from the foeto-placental unit .
23427921	0	steroid_K-canrenoate	14,34	hsp70	38,43	steroid K-canrenoate	hsp70	null	44920(Tax:7227)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effect of the steroid_K-canrenoate on hsp70 expression and tissue damage in transgenic Drosophila_melanogaster -LRB- hsp70-lacZ -RRB- Bg9 .
22759411	0	steroid_hormone	75,90	corticotrophin-releasing_hormone	19,51	steroid hormone	corticotrophin-releasing hormone	CHEBI:26764	1392	Chemical	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	Modulation of free corticotrophin-releasing_hormone , adrenal and placental steroid_hormone levels induced by mifepristone during pregnancy .
12965238	0	steroid_nandrolone_decanoate	20,48	proopiomelanocortin	70,89	steroid nandrolone decanoate	proopiomelanocortin	null	5443	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|levels levels|compound|END_ENTITY	Anabolic androgenic steroid_nandrolone_decanoate reduces hypothalamic proopiomelanocortin mRNA levels .
2723028	0	steroid_stanozolol	54,72	Sex_hormone-binding_globulin	0,28	steroid stanozolol	Sex hormone-binding globulin	null	6462	Chemical	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Sex_hormone-binding_globulin response to the anabolic steroid_stanozolol : evidence for its suitability as a biological androgen sensitivity test .
18330246	0	steroidal_glycoside	15,34	C21	11,14	steroidal glycoside	C21	CHEBI:61655	81004(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	-LSB- Effect of C21 steroidal_glycoside from root of Cynanchum auriculatum on D-galactose induced aging model mice -RSB- .
18539445	0	steroidal_glycosides	27,47	C-21	22,26	steroidal glycosides	C-21	CHEBI:61655	79718	Chemical	Gene	START_ENTITY|nsubj|activity activity|nmod|END_ENTITY	Antitumor activity of C-21 steroidal_glycosides from Cynanchum auriculatum Royle ex Wight .
16468369	0	steroidal_glycosides	22,42	C21	18,21	steroidal glycosides	C21	CHEBI:61655	79718	Chemical	Gene	START_ENTITY|nsubj|Determination Determination|nmod|END_ENTITY	-LSB- Determination of C21 steroidal_glycosides in Marsdenia tenacissima by colorimetric method -RSB- .
21782943	0	steroidal_lactones	4,22	androgen_receptor	74,91	steroidal lactones	androgen receptor	null	367	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	New steroidal_lactones as 5a-reductase inhibitors and antagonists for the androgen_receptor .
17624893	0	steroidal_saponins	41,59	C21	37,40	steroidal saponins	C21	null	79718	Chemical	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification and quantification of C21 steroidal_saponins from Radix Cynanchi Atrati by high-performance liquid chromatography with evaporative light scattering detection and electrospray mass spectrometric detection .
6597979	0	steroids	97,105	17_beta-hydroxysteroid_dehydrogenase	14,50	steroids	17 beta-hydroxysteroid dehydrogenase	MESH:D013256	51478	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activities activities|amod|END_ENTITY	Inhibition of 17_beta-hydroxysteroid_dehydrogenase -LRB- 17_beta-HSD -RRB- activities of human placenta by steroids and non-steroidal hormone agonists and antagonists .
16134943	0	steroids	16,24	17beta-hydroxysteroid_dehydrogenase_type_1	55,97	steroids	17beta-hydroxysteroid dehydrogenase type 1	MESH:D013256	3292	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	E-ring modified steroids as novel potent inhibitors of 17beta-hydroxysteroid_dehydrogenase_type_1 .
15246773	0	steroids	40,48	5Alpha-reductase	0,16	steroids	5Alpha-reductase	MESH:D013256	6715	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	5Alpha-reductase inhibition activity of steroids isolated from marine soft corals .
12419908	0	steroids	68,76	5_Alpha-reductase	0,17	steroids	5 Alpha-reductase	MESH:D013256	6715	Chemical	Gene	activities|nmod|START_ENTITY activities|amod|END_ENTITY	5_Alpha-reductase inhibitory and antiandrogenic activities of novel steroids in hamster seminal vesicles .
1828548	0	steroids	15,23	5_alpha-reductase	32,49	steroids	5 alpha-reductase	MESH:D013256	6715	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|amod|END_ENTITY	Effects of sex steroids on skin 5_alpha-reductase activity in vitro .
17340816	0	steroids	49,57	ACTH	68,72	steroids	ACTH	MESH:D013256	5443	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	-LSB- Comparative evaluation of the influence of some steroids on plasma ACTH levels -RSB- .
24860741	0	steroids	69,77	ACTH	12,16	steroids	ACTH	MESH:D013256	5443	Chemical	Gene	dose|nmod|START_ENTITY test|nmod|dose test|amod|END_ENTITY	Role of the ACTH test and estimation of a safe dose for high potency steroids in vitiligo : A prospective randomized study .
6273656	0	steroids	50,58	ACTH	10,14	steroids	ACTH	MESH:D013256	5443	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of ACTH on the subcellular distribution of steroids in the adrenal gland .
6306346	0	steroids	39,47	ACTH	73,77	steroids	ACTH	MESH:D013256	5443	Chemical	Gene	response|nmod|START_ENTITY response|nmod|administration administration|nmod|END_ENTITY	The response of several adrenocortical steroids to the administration of ACTH in hirsute women .
7586600	0	steroids	35,43	ACTH	56,60	steroids	ACTH	MESH:D013256	5443	Chemical	Gene	adrenocortical|dobj|START_ENTITY adrenocortical|nmod|END_ENTITY	Responses of plasma adrenocortical steroids to low dose ACTH in normal subjects .
15639315	0	steroids	4,12	APOE	14,18	steroids	APOE	MESH:D013256	11816(Tax:10090)	Chemical	Gene	START_ENTITY|appos|genotype genotype|amod|END_ENTITY	Sex steroids , APOE genotype and the innate immune system .
7129353	0	steroids	32,40	Angiotensin_II	0,14	steroids	Angiotensin II	MESH:D013256	183	Chemical	Gene	effect|nmod|START_ENTITY effect|compound|END_ENTITY	Angiotensin_II effect on plasma steroids in selective hypoaldosteronism .
11268216	0	steroids	69,77	BRI1	0,4	steroids	BRI1	MESH:D013256	830095(Tax:3702)	Chemical	Gene	receptor|nmod|START_ENTITY component|nmod|receptor component|nsubj|END_ENTITY	BRI1 is a critical component of a plasma-membrane receptor for plant steroids .
7229449	0	steroids	18,26	C19-21	11,17	steroids	C19-21	MESH:D013256	1035837(Tax:199310)	Chemical	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	-LSB- Change of C19-21 steroids levels of maternal serum , amnion and cord plasma by high pressure liquid chromatography -LRB- HPLC -RRB- -LRB- author 's transl -RRB- -RSB- .
8721049	0	steroids	36,44	C21	32,35	steroids	C21	MESH:D013256	79718	Chemical	Gene	concentration|compound|START_ENTITY concentration|compound|END_ENTITY	-LSB- A study on the maternal plasma C21 steroids concentration during pregnancy -RSB- .
11549528	0	steroids	16,24	CXCR3	34,39	steroids	CXCR3	MESH:D013256	2833	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of oral steroids on blood CXCR3 + and CCR4 + T cells in patients with bronchial_asthma .
12642469	0	steroids	100,108	CYP3A4	0,6	steroids	CYP3A4	MESH:D013256	1576	Chemical	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	CYP3A4 and CYP3A7-mediated carbamazepine 10,11-epoxidation are activated by differential endogenous steroids .
11598380	0	steroids	47,55	Dexras1	14,21	steroids	Dexras1	MESH:D013256	19416(Tax:10090)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of Dexras1 expression by endogenous steroids .
17405825	0	steroids	51,59	FSHbeta	18,25	steroids	FSHbeta	MESH:D013256	25447(Tax:10116)	Chemical	Gene	transcription|nmod|START_ENTITY transcription|compound|END_ENTITY	The regulation of FSHbeta transcription by gonadal steroids : testosterone and estradiol modulation of the activin intracellular signaling pathway .
10830556	0	steroids	68,76	Focal_segmental_glomerulosclerosis	0,34	steroids	Focal segmental glomerulosclerosis	MESH:D013256	81	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|dep|effects	Focal_segmental_glomerulosclerosis in African Americans : effects of steroids and angiotensin converting enzyme inhibitors .
11182142	0	steroids	132,140	GAPDH	144,149	steroids	GAPDH	MESH:D013256	24383(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Binding of estrogen and progesterone-BSA conjugates to glyceraldehyde-3-phosphate_dehydrogenase -LRB- GAPDH -RRB- and the effects of the free steroids on GAPDH enzyme activity : physiological implications .
1958517	0	steroids	19,27	GH	65,67	steroids	GH	MESH:D013256	2688	Chemical	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of sexual steroids in the modulation of growth_hormone -LRB- GH -RRB- secretion in humans .
20947496	0	steroids	43,51	GPRC6A	0,6	steroids	GPRC6A	MESH:D013256	210198(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY mediates|dobj|effects mediates|nsubj|END_ENTITY	GPRC6A mediates the non-genomic effects of steroids .
14764000	0	steroids	64,72	GalR1	31,36	steroids	GalR1	MESH:D013256	50577(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Regulation of galanin receptor GalR1 mRNA expression by ovarian steroids in oestrogen receptor alpha-immunoreactive neurones : identification of distinct populations of neurones in the preoptic area .
8950619	0	steroids	89,97	Growth_hormone	0,14	steroids	Growth hormone	MESH:D013256	2688	Chemical	Gene	interactions|nmod|START_ENTITY factor-I|dep|interactions factor-I|amod|END_ENTITY	Growth_hormone , insulin-like growth factor-I and lipid metabolism : interactions with sex steroids .
20814169	0	steroids	10,18	HOXA10	22,28	steroids	HOXA10	MESH:D013256	3206	Chemical	Gene	START_ENTITY|nmod|mRNA mRNA|compound|END_ENTITY	Effect of steroids on HOXA10 mRNA and protein expression and prostaglandin production in the porcine endometrium .
15641264	0	steroids	19,27	IGF-1	33,38	steroids	IGF-1	MESH:D013256	3479	Chemical	Gene	Correlation|nmod|START_ENTITY Correlation|nmod|END_ENTITY	Correlation of sex steroids with IGF-1 and IGFBP-3 during different pubertal stages .
11158935	0	steroids	98,106	IGF-I	13,18	steroids	IGF-I	MESH:D013256	3479	Chemical	Gene	modulation|nmod|START_ENTITY END_ENTITY|dep|modulation	Reduced free IGF-I and increased IGFBP-3 proteolysis in Turner_syndrome : modulation by female sex steroids .
8508557	0	steroids	18,26	IL-1	48,52	steroids	IL-1	MESH:D013256	3552	Chemical	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	Effect of gonadal steroids on the production of IL-1 and IL-6 by blood mononuclear cells in vitro .
11814313	0	steroids	20,28	IL-6	37,41	steroids	IL-6	MESH:D013256	3569	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|secretion secretion|compound|END_ENTITY	Adrenal and gonadal steroids inhibit IL-6 secretion by human marrow cells .
15475534	0	steroids	104,112	IL-6	116,120	steroids	IL-6	MESH:D013256	24498(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|regulation regulation|compound|END_ENTITY	Mechanism of cardiac_depression after trauma-hemorrhage : increased cardiomyocyte IL-6 and effect of sex steroids on IL-6 regulation and cardiac function .
9329961	0	steroids	70,78	IL-6	49,53	steroids	IL-6	MESH:D013256	16193(Tax:10090)	Chemical	Gene	receptor|nmod|START_ENTITY receptor|compound|END_ENTITY	Regulation of the gp80 and gp130 subunits of the IL-6 receptor by sex steroids in the murine bone marrow .
16448811	0	steroids	52,60	IL-8	36,40	steroids	IL-8	MESH:D013256	3576	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of pyocyanin-potentiated IL-8 release by steroids in bronchial epithelial cells .
24647471	0	steroids	79,87	IL-8	59,63	steroids	IL-8	MESH:D013256	3576	Chemical	Gene	induces|nmod|START_ENTITY induces|dobj|repression repression|compound|END_ENTITY	Sphingosine_1-phosphate induces neutrophil chemoattractant IL-8 : repression by steroids .
9217378	0	steroids	44,52	IL-8	86,90	steroids	IL-8	MESH:D013256	3576	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	-LSB- Effects of pre-operative administration of steroids on the serum interleukin _ -LRB- IL -RRB- -6 , IL-8 and organ_injuries in replacement of thoracic aorta -RSB- .
21456035	0	steroids	58,66	Interleukin-18	0,14	steroids	Interleukin-18	MESH:D013256	3606	Chemical	Gene	use|nmod|START_ENTITY associated|nmod|use associated|nsubjpass|upregulation upregulation|amod|END_ENTITY	Interleukin-18 upregulation is associated with the use of steroids in patients with ulcerative_colitis .
15831567	0	steroids	57,65	KiSS-1	27,33	steroids	KiSS-1	MESH:D013256	280287(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Differential regulation of KiSS-1 mRNA expression by sex steroids in the brain of the male mouse .
17185374	0	steroids	96,104	KiSS-1	0,6	steroids	KiSS-1	MESH:D013256	3814	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|compound|END_ENTITY	KiSS-1 messenger ribonucleic acid expression in the hypothalamus of the ewe is regulated by sex steroids and season .
21363930	0	steroids	38,46	Kiss1	14,19	steroids	Kiss1	MESH:D013256	289023(Tax:10116)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of Kiss1 expression by sex steroids in the amygdala of the rat and mouse .
109032	1	steroids	147,155	LH-RH	95,100	steroids	LH-RH	MESH:D013256	2796	Chemical	Gene	study|nmod|START_ENTITY test|nmod|study test|nsubj|Study Study|nmod|light light|nmod|data data|nmod|TRH TRH|compound|END_ENTITY	Study in the light of data from the combined LH-RH + TRH test together with the study of ovarian steroids -RSB- .
361380	0	steroids	10,18	LH-RH	39,44	steroids	LH-RH	MESH:D013256	25194(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	Effect of steroids in combination with LH-RH on the release of LH and FSH in LH-RH-primed immature male rat .
4609751	0	steroids	31,39	LH-RH	0,5	steroids	LH-RH	MESH:D013256	2796	Chemical	Gene	modulated|nmod|START_ENTITY modulated|nsubj|actions actions|amod|END_ENTITY	LH-RH actions modulated by sex steroids .
51948	0	steroids	22,30	LH-RH	60,65	steroids	LH-RH	MESH:D013256	2796	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Regulatory effects of steroids on the pituitary response to LH-RH .
767171	0	steroids	26,34	LH-RH	109,114	steroids	LH-RH	MESH:D013256	2796	Chemical	Gene	Effects|nmod|START_ENTITY responsiveness|nsubj|Effects responsiveness|nmod|-RSB- -RSB-|amod|luteinizing_hormone_releasing_hormone luteinizing_hormone_releasing_hormone|dep|END_ENTITY	-LSB- Effects of synthetic sex steroids on the pituitary responsiveness to luteinizing_hormone_releasing_hormone -LRB- LH-RH -RRB- -LRB- author 's transl -RRB- -RSB- .
16767524	0	steroids	15,23	MrOS	84,88	steroids	MrOS	MESH:D013256	8011	Chemical	Gene	START_ENTITY|dep|study study|compound|END_ENTITY	Endogenous sex steroids , weight change and rates of hip bone_loss in older men : the MrOS study .
23994685	0	steroids	107,115	Multi-drug_resistance-1	0,23	steroids	Multi-drug resistance-1	MESH:D013256	5243	Chemical	Gene	impact|nmod|START_ENTITY polymorphisms|dep|impact polymorphisms|amod|END_ENTITY	Multi-drug_resistance-1 gene polymorphisms in nephrotic_syndrome : impact on susceptibility and response to steroids .
11351337	0	steroids	35,43	N-cadherin	0,10	steroids	N-cadherin	MESH:D013256	83501(Tax:10116)	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	N-cadherin is regulated by gonadal steroids in adult sexually dimorphic spinal motoneurons .
2243540	0	steroids	28,36	ODC	58,61	steroids	ODC	MESH:D013256	24609(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activity activity|compound|END_ENTITY	Differential effects of sex steroids on uterine and renal ODC activity in ovariectomized rats .
9292183	0	steroids	79,87	P-glycoprotein_170	14,32	steroids	P-glycoprotein 170	MESH:D013256	283871	Chemical	Gene	increased|nmod|START_ENTITY increased|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of P-glycoprotein_170 in nasal mucosa may be increased with topical steroids .
17728018	0	steroids	45,53	PS2	0,3	steroids	PS2	MESH:D013256	19165(Tax:10090)	Chemical	Gene	upregulated|nmod|START_ENTITY upregulated|nsubjpass|expression expression|nummod|END_ENTITY	PS2 protein expression is upregulated by sex steroids in the cerebral cortex of aging mice .
18048494	0	steroids	60,68	PTX3	19,23	steroids	PTX3	MESH:D013256	5806	Chemical	Gene	regulation|nmod|START_ENTITY END_ENTITY|dep|regulation	The long pentraxin PTX3 in human endometrium : regulation by steroids and trophoblast products .
17761890	3	steroids	411,419	Per1	435,439	steroids	Per1	MESH:D013256	287422(Tax:10116)	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|amod|END_ENTITY	Here , we examined the expression of Per1 in different compartments of the uterus , and explored whether the ovarian steroids could regulate Per1 expression employing ovariectomized rat uterus .
23669457	0	steroids	51,59	Progesterone_receptor	0,21	steroids	Progesterone receptor	MESH:D013256	5241	Chemical	Gene	targeting|nmod|START_ENTITY targeting|compound|END_ENTITY	Progesterone_receptor targeting with radiolabelled steroids : an approach in predicting breast_cancer response to therapy .
9926835	0	steroids	67,75	Progesterone_receptor	0,21	steroids	Progesterone receptor	MESH:D013256	25154(Tax:10116)	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|isoforms isoforms|compound|END_ENTITY	Progesterone_receptor isoforms are differentially regulated by sex steroids in the rat forebrain .
23216986	0	steroids	36,44	S100P	0,5	steroids	S100P	MESH:D013256	6286	Chemical	Gene	expression|nmod|START_ENTITY expression|nsubj|END_ENTITY	S100P expression in response to sex steroids during the implantation window in human endometrium .
566170	0	steroids	107,115	Sex_hormone_binding_globulin	0,28	steroids	Sex hormone binding globulin	MESH:D013256	6462	Chemical	Gene	the|nmod|START_ENTITY capacity|nmod|the END_ENTITY|dep|capacity	Sex_hormone_binding_globulin : binding capacity and studies on the binding of cyproterone_acetate and other steroids .
7197136	0	steroids	50,58	Sex_hormone_binding_globulin	0,28	steroids	Sex hormone binding globulin	MESH:D013256	6462	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|dep|effect	Sex_hormone_binding_globulin : effect of synthetic steroids on the assay and effect of oral contraceptives .
22348610	0	steroids	102,110	TSPO	114,118	steroids	TSPO	MESH:D013256	706	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	The role of 18 kDa mitochondrial translocator_protein -LRB- TSPO -RRB- in programmed cell death , and effects of steroids on TSPO expression .
12464076	0	steroids	60,68	VEGF	11,15	steroids	VEGF	MESH:D013256	7422	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of VEGF and bFGF on proliferation and production of steroids and nitric_oxide in porcine granulosa cells .
17113146	0	steroids	30,38	VEGF	60,64	steroids	VEGF	MESH:D013256	443103(Tax:9940)	Chemical	Gene	Reduction|nmod|START_ENTITY results|nsubj|Reduction results|nmod|protein protein|amod|END_ENTITY	Reduction of maternal adrenal steroids results in increased VEGF protein without increased eNOS in the ovine placenta .
2989980	0	steroids	31,39	VIP	95,98	steroids	VIP	MESH:D013256	100352512(Tax:9986)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|effect effect|nmod|END_ENTITY	Influence of pregnancy and sex steroids on concentration , motor effect and receptor binding of VIP in the rabbit female genital tract .
20096895	0	steroids	89,97	adiponectin	46,57	steroids	adiponectin	MESH:D013256	9370	Chemical	Gene	concentrations|nmod|START_ENTITY concentrations|nmod|END_ENTITY	Serum concentrations of high-molecular weight adiponectin and their association with sex steroids in premenopausal women .
17065400	0	steroids	73,81	adrenomedullin	14,28	steroids	adrenomedullin	MESH:D013256	133	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of adrenomedullin release from human endothelial cells by sex steroids and angiotensin-II .
12604203	0	steroids	67,75	alcohol_dehydrogenase_1C	21,45	steroids	alcohol dehydrogenase 1C	MESH:D013256	126	Chemical	Gene	Specificity|nmod|START_ENTITY Specificity|nmod|END_ENTITY	Specificity of human alcohol_dehydrogenase_1C * 2 -LRB- gamma2gamma2 -RRB- for steroids and simulation of the uncompetitive inhibition of ethanol metabolism .
60142	1	steroids	102,110	alpha-foetoprotein	62,80	steroids	alpha-foetoprotein	MESH:D013256	24177(Tax:10116)	Chemical	Gene	metabolism|nmod|START_ENTITY END_ENTITY|nmod|metabolism	I. - Influence of alpha-foetoprotein on the metabolism of steroids by rat liver microsomes in vitro .
1713521	0	steroids	14,22	alpha_2-macroglobulin	52,73	steroids	alpha 2-macroglobulin	MESH:D013256	24153(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|nmod|END_ENTITY	Effect of sex steroids on the circulating levels of alpha_2-macroglobulin in injured rats .
10500149	0	steroids	94,102	androgen_receptor	47,64	steroids	androgen receptor	MESH:D013256	367	Chemical	Gene	transactivation|nmod|START_ENTITY transactivation|compound|END_ENTITY	Suppression of Delta -LRB- 5 -RRB- - androstenediol-induced androgen_receptor transactivation by selective steroids in human prostate_cancer cells .
10724337	0	steroids	105,113	androgen_receptor	33,50	steroids	androgen receptor	MESH:D013256	11835(Tax:10090)	Chemical	Gene	Synthesis|nmod|START_ENTITY Synthesis|nmod|END_ENTITY	Synthesis and phosphorylation of androgen_receptor of the mouse brain cortex and their regulation by sex steroids during aging .
12773127	0	steroids	150,158	androgen_receptor	43,60	steroids	androgen receptor	MESH:D013256	397582(Tax:9823)	Chemical	Gene	uterus|nmod|START_ENTITY uterus|nsubj|Distribution Distribution|nmod|amounts amounts|nmod|END_ENTITY	Distribution and changes in amounts of the androgen_receptor in the pig uterus during the estrous cycle , early pregnancy and after treatment with sex steroids .
1428232	0	steroids	51,59	androgen_receptor	14,31	steroids	androgen receptor	MESH:D013256	367	Chemical	Gene	expression|nmod|START_ENTITY expression|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of androgen_receptor gene expression by steroids and retinoic_acid in human breast-cancer cells .
15530646	0	steroids	4,12	androgen_receptor	44,61	steroids	androgen receptor	MESH:D013256	11835(Tax:10090)	Chemical	Gene	reduce|nsubj|START_ENTITY reduce|dobj|accessibility accessibility|nmod|promoter promoter|compound|END_ENTITY	Sex steroids reduce DNaseI accessibility of androgen_receptor promoter in adult male mice brain .
18637017	0	steroids	101,109	androgen_receptor	31,48	steroids	androgen receptor	MESH:D013256	367	Chemical	Gene	receptor|nmod|START_ENTITY activation|nmod|receptor causes|dobj|activation causes|nsubj|mutation mutation|nmod|END_ENTITY	An S296R mutation in the human androgen_receptor causes activation of the receptor by non-androgenic steroids and stronger inhibition by the nuclear receptor corepressor N-coR .
19028512	0	steroids	50,58	androgen_receptor	90,107	steroids	androgen receptor	MESH:D013256	367	Chemical	Gene	characteristics|nmod|START_ENTITY characteristics|acl|contributing contributing|xcomp|binding binding|nmod|END_ENTITY	Structural characteristics of anabolic androgenic steroids contributing to binding to the androgen_receptor and to their anabolic and androgenic activities .
22484622	0	steroids	26,34	androgen_receptor	38,55	steroids	androgen receptor	MESH:D013256	367	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activation activation|compound|END_ENTITY	Effects of CYP7B1-related steroids on androgen_receptor activation in different cell lines .
23260236	0	steroids	30,38	androgen_receptor	70,87	steroids	androgen receptor	MESH:D013256	367	Chemical	Gene	studies|nmod|START_ENTITY studies|nmod|ligands ligands|compound|END_ENTITY	Docking and CoMSIA studies on steroids and non-steroidal chemicals as androgen_receptor ligands .
3488063	0	steroids	52,60	androgen_receptor	17,34	steroids	androgen receptor	MESH:D013256	24208(Tax:10116)	Chemical	Gene	Stabilization|nmod|START_ENTITY Stabilization|nmod|END_ENTITY	Stabilization of androgen_receptor by nonandrogenic steroids .
3762019	0	steroids	65,73	androgen_receptor	14,31	steroids	androgen receptor	MESH:D013256	367	Chemical	Gene	binding|nmod|START_ENTITY binding|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of androgen_receptor binding by natural and synthetic steroids in cultured human genital skin fibroblasts .
6611254	0	steroids	72,80	androgen_receptor	28,45	steroids	androgen receptor	MESH:D013256	24208(Tax:10116)	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|END_ENTITY	Modulation of the cytosolic androgen_receptor in striated muscle by sex steroids .
7075544	7	steroids	1572,1580	androgen_receptor	1519,1536	steroids	androgen receptor	MESH:D013256	24208(Tax:10116)	Chemical	Gene	both|nmod|START_ENTITY observed|nmod|both T.|acl:relcl|observed did|dobj|T. produce|advcl|did produce|dobj|degree degree|nmod|occupancy occupancy|nmod|sites sites|compound|END_ENTITY	Progesterone -LRB- 1 mg -RRB- and estradiol -LRB- 0.6 mg -RRB- were also injected in amounts calculated to produce the same degree of occupancy of androgen_receptor sites as did T. With both of these steroids , nuclear accumulation of androgen_receptor was observed , but neither progesterone nor estradiol induced de novo synthesis of androgen_receptor .
7132347	0	steroids	121,129	androgen_receptor	54,71	steroids	androgen receptor	MESH:D013256	24208(Tax:10116)	Chemical	Gene	competition|nmod|START_ENTITY properties|dep|competition properties|nmod|END_ENTITY	Steroid-binding properties of the rat seminal vesicle androgen_receptor : short-term and long-term competition of various steroids with radioactive dihydrotestosterone .
3023151	0	steroids	84,92	angiotensin_II	96,110	steroids	angiotensin II	MESH:D013256	183	Chemical	Gene	START_ENTITY|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Studies on hypoaldosteronism associated with diabetes_mellitus : response of plasma steroids to angiotensin_II or ACTH administration -RSB- .
3990909	0	steroids	116,124	angiotensin_II	37,51	steroids	angiotensin II	MESH:D013256	24179(Tax:10116)	Chemical	Gene	function|nmod|START_ENTITY effects|dep|function effects|nmod|END_ENTITY	Stimulatory or inhibitory effects of angiotensin_II upon LH secretion in ovariectomized rats : a function of gonadal steroids .
4285180	0	steroids	28,36	angiotensin_II	49,63	steroids	angiotensin II	MESH:D013256	183	Chemical	Gene	biosynthesis|nmod|START_ENTITY biosynthesis|dep|effects effects|nmod|END_ENTITY	The biosynthesis of adrenal steroids : effects of angiotensin_II , adrenocorticotropin , and potassium .
7594440	0	steroids	86,94	angiotensin_II	22,36	steroids	angiotensin II	MESH:D013256	24179(Tax:10116)	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|Expression Expression|nmod|genes genes|compound|END_ENTITY	Expression of cardiac angiotensin_II AT1 receptor genes in rat hearts is regulated by steroids but not by angiotensin_II .
1868457	0	steroids	45,53	apolipoprotein_D	15,31	steroids	apolipoprotein D	MESH:D013256	347	Chemical	Gene	secretion|nmod|START_ENTITY secretion|amod|END_ENTITY	Stimulation of apolipoprotein_D secretion by steroids coincides with inhibition of cell proliferation in human LNCaP_prostate_cancer cells .
7652597	0	steroids	37,45	arginine_vasopressin	49,69	steroids	arginine vasopressin	MESH:D013256	24221(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	-LSB- Effect of glucocorticoids and other steroids on arginine_vasopressin release from rat hypothalamic slices -RSB- .
10360915	0	steroids	14,22	beta-endorphin	26,40	steroids	beta-endorphin	MESH:D013256	5443	Chemical	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	Effect of sex steroids on beta-endorphin levels at rest and during submaximal treadmill exercise in anovulatory and ovulatory runners .
1442140	0	steroids	78,86	beta-endorphin	43,57	steroids	beta-endorphin	MESH:D013256	5443	Chemical	Gene	studies|nmod|START_ENTITY studies|nmod|effects effects|nmod|END_ENTITY	In vivo and in vitro studies on effects of beta-endorphin and naloxone on sex steroids in the water frog , Rana esculenta .
6288755	0	steroids	14,22	beta-endorphin	26,40	steroids	beta-endorphin	MESH:D013256	5443	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of sex steroids on beta-endorphin in hypophyseal portal blood .
16932963	0	steroids	32,40	beta2	58,63	steroids	beta2	MESH:D013256	10242	Chemical	Gene	START_ENTITY|nmod|agonists agonists|amod|END_ENTITY	Does the combination of inhaled steroids with long acting beta2 agonists decrease the risk for osteoporosis ?
6282726	0	steroids	16,24	c-AMP	40,45	steroids	c-AMP	MESH:D013256	316010(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|response response|amod|END_ENTITY	Role of adrenal steroids on the cardiac c-AMP response to isoprenaline in the rat .
10362688	0	steroids	87,95	calcitonin_gene-related_peptide	11,42	steroids	calcitonin gene-related peptide	MESH:D013256	24241(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY Effects|dep|role Effects|nmod|END_ENTITY	Effects of calcitonin_gene-related_peptide on vascular resistance in rats : role of sex steroids .
8253061	0	steroids	10,18	complement_C3	39,52	steroids	complement C3	MESH:D013256	718	Chemical	Gene	START_ENTITY|nmod|synthesis synthesis|nmod|END_ENTITY	Effect of steroids on the synthesis of complement_C3 in a human alveolar epithelial cell line .
6602859	0	steroids	161,169	corticotrophin_releasing_factor	46,77	steroids	corticotrophin releasing factor	MESH:D013256	81648(Tax:10116)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|inhibition inhibition|nmod|END_ENTITY	Biphasic inhibition of bioactive hypothalamic corticotrophin_releasing_factor secretion in vitro by corticosterone and prevention of the second phase by various steroids .
11528220	0	steroids	16,24	corticotropin-releasing_hormone	32,63	steroids	corticotropin-releasing hormone	MESH:D013256	81648(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|response response|amod|END_ENTITY	Role of gonadal steroids in the corticotropin-releasing_hormone and proopiomelanocortin gene expression response to Delta -LRB- 9 -RRB- - tetrahydrocannabinol in the hypothalamus of the rat .
7617129	0	steroids	19,27	corticotropin-releasing_hormone	97,128	steroids	corticotropin-releasing hormone	MESH:D013256	1392	Chemical	Gene	Removal|nmod|START_ENTITY reverses|nsubj|Removal reverses|dobj|effect effect|nmod|catecholamines catecholamines|nmod|neurons neurons|amod|END_ENTITY	Removal of adrenal steroids from the medium reverses the stimulating effect of catecholamines on corticotropin-releasing_hormone neurons in organotypic cultures .
8824343	0	steroids	8,16	corticotropin-releasing_hormone	117,148	steroids	corticotropin-releasing hormone	MESH:D013256	81648(Tax:10116)	Chemical	Gene	exert|nsubj|START_ENTITY exert|nmod|regulation regulation|nmod|genes genes|amod|END_ENTITY	Gonadal steroids exert facilitating and `` buffering '' effects on glucocorticoid-mediated transcriptional regulation of corticotropin-releasing_hormone and corticosteroid receptor genes in rat brain .
10601967	0	steroids	60,68	cytochrome-c_oxidase	16,36	steroids	cytochrome-c oxidase	MESH:D013256	304024(Tax:10116)	Chemical	Gene	control|nmod|START_ENTITY control|nmod|activity activity|amod|END_ENTITY	Dual control of cytochrome-c_oxidase activity by female sex steroids .
6540703	0	steroids	42,50	elastin	54,61	steroids	elastin	MESH:D013256	25043(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|content content|compound|END_ENTITY	Effect of some selected anti-inflammatory steroids on elastin content in liver of rats treated with carbon_tetrachloride .
10202995	0	steroids	181,189	eosinophil_cationic_protein	6,33	steroids	eosinophil cationic protein	MESH:D013256	6037	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|END_ENTITY	Serum eosinophil_cationic_protein -LRB- ECP -RRB- as a mediator of inflammation in acute asthma , during resolution and during the monitoring of stable asthmatic patients treated with inhaled steroids according to a dose reduction schedule .
8882285	0	steroids	68,76	epidermal_growth_factor_receptor	14,46	steroids	epidermal growth factor receptor	MESH:D013256	1956	Chemical	Gene	synthesis|nmod|START_ENTITY synthesis|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of epidermal_growth_factor_receptor synthesis by ovarian steroids in human endometrial cells in culture .
16020995	0	steroids	11,19	focal_segmental_glomerulosclerosis	23,57	steroids	focal segmental glomerulosclerosis	MESH:D013256	81	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of steroids in focal_segmental_glomerulosclerosis in a predominantly African-American population .
21889601	0	steroids	18,26	foxl2	48,53	steroids	foxl2	MESH:D013256	668	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of sexual steroids on the expression of foxl2 in Gobiocypris_rarus .
10681370	0	steroids	80,88	glucocorticoid_receptor	4,27	steroids	glucocorticoid receptor	MESH:D013256	2908	Chemical	Gene	essential|nmod|START_ENTITY essential|nsubj|END_ENTITY	The glucocorticoid_receptor is essential for induction of cytochrome P-4502B by steroids but not for drug or steroid induction of CYP3A or P-450 reductase in mouse liver .
6428971	0	steroids	31,39	gonadotrophin-releasing_hormone	91,122	steroids	gonadotrophin-releasing hormone	MESH:D013256	2796	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|agonist agonist|amod|END_ENTITY	Effects of gonadectomy and sex steroids on pituitary gonadotrophin release and response to gonadotrophin-releasing_hormone -LRB- GnRH -RRB- agonist in the bullfrog , Rana catesbeiana .
7012514	0	steroids	32,40	gonadotropin-releasing_hormone	44,74	steroids	gonadotropin-releasing hormone	MESH:D013256	2796	Chemical	Gene	START_ENTITY|nmod|agonists agonists|amod|END_ENTITY	Inhibition of the action of sex steroids by gonadotropin-releasing_hormone -LRB- GnRH -RRB- agonists : a new biological effect .
15761040	0	steroids	48,56	growth_hormone	14,28	steroids	growth hormone	MESH:D013256	102171600	Chemical	Gene	pulsatility|nmod|START_ENTITY pulsatility|nsubj|Modulation Modulation|nmod|END_ENTITY	Modulation of growth_hormone pulsatility by sex steroids in female goats .
163560	0	steroids	52,60	growth_hormone	6,20	steroids	growth hormone	MESH:D013256	2688	Chemical	Gene	START_ENTITY|amod|gonadotrophins gonadotrophins|dep|END_ENTITY	Serum growth_hormone and gonadotrophins and urinary steroids in adolescent girls .
16809927	0	steroids	48,56	growth_hormone	14,28	steroids	growth hormone	MESH:D013256	2688	Chemical	Gene	Regulating|nmod|START_ENTITY Regulating|nmod|sensitivity sensitivity|amod|END_ENTITY	Regulating of growth_hormone sensitivity by sex steroids : implications for therapy .
16984231	0	steroids	43,51	growth_hormone	14,28	steroids	growth hormone	MESH:D013256	2688	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|action action|amod|END_ENTITY	Modulation of growth_hormone action by sex steroids .
1958517	0	steroids	19,27	growth_hormone	49,63	steroids	growth hormone	MESH:D013256	2688	Chemical	Gene	START_ENTITY|nmod|modulation modulation|nmod|END_ENTITY	The role of sexual steroids in the modulation of growth_hormone -LRB- GH -RRB- secretion in humans .
1989846	0	steroids	19,27	growth_hormone	44,58	steroids	growth hormone	MESH:D013256	81668(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of gonadal steroids on clearance of growth_hormone at steady state in the rat .
19940496	0	steroids	55,63	growth_hormone	4,18	steroids	growth hormone	MESH:D013256	2688	Chemical	Gene	effects|nmod|START_ENTITY counteract|dobj|effects counteract|nsubj|END_ENTITY	Can growth_hormone counteract the catabolic effects of steroids ?
25538882	0	steroids	22,30	growth_hormone	63,77	steroids	growth hormone	MESH:D013256	2688	Chemical	Gene	improve|nmod|START_ENTITY improve|dobj|diagnosis diagnosis|nmod|secretion secretion|compound|END_ENTITY	Does priming with sex steroids improve the diagnosis of normal growth_hormone secretion in short children ?
2827218	0	steroids	8,16	growth_hormone	37,51	steroids	growth hormone	MESH:D013256	2688	Chemical	Gene	affect|nsubj|START_ENTITY affect|dobj|response response|compound|END_ENTITY	Gonadal steroids do not affect basal growth_hormone response to naloxone in humans .
3126262	0	steroids	15,23	growth_hormone	27,41	steroids	growth hormone	MESH:D013256	81668(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|responses responses|amod|END_ENTITY	Effects of sex steroids on growth_hormone responses to clonidine and GHRH in reserpine pretreated rats .
5440426	0	steroids	29,37	growth_hormone	51,65	steroids	growth hormone	MESH:D013256	81668(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of some contraceptive steroids on pituitary growth_hormone content in female rats .
579534	0	steroids	15,23	growth_hormone	27,41	steroids	growth hormone	MESH:D013256	81668(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|production production|amod|END_ENTITY	Effects of sex steroids on growth_hormone production in cultured rat pituitary cells .
6705738	0	steroids	21,29	growth_hormone	76,90	steroids	growth hormone	MESH:D013256	81668(Tax:10116)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of gonadal steroids on age - and sex-related secretory patterns of growth_hormone in the rat .
8742123	0	steroids	4,12	growth_hormone	14,28	steroids	growth hormone	MESH:D013256	2688	Chemical	Gene	START_ENTITY|amod|insulin-like_growth_factor-1 insulin-like_growth_factor-1|amod|END_ENTITY	Sex steroids , growth_hormone , insulin-like_growth_factor-1 : neuroendocrine and metabolic regulation in puberty .
9062497	0	steroids	88,96	growth_hormone	4,18	steroids	growth hormone	MESH:D013256	2688	Chemical	Gene	reproducibility|nmod|START_ENTITY response|dep|reproducibility response|amod|END_ENTITY	The growth_hormone response to hexarelin in children : reproducibility and effect of sex steroids .
18752655	0	steroids	127,135	growth_hormone-releasing_hormone	54,86	steroids	growth hormone-releasing hormone	MESH:D013256	14601(Tax:10090)	Chemical	Gene	modulation|nmod|START_ENTITY distribution|dep|modulation distribution|nmod|receptors receptors|nmod|neurones neurones|amod|END_ENTITY	Sexually dimorphic distribution of sst2A receptors on growth_hormone-releasing_hormone neurones in mice : modulation by gonadal steroids .
2568924	0	steroids	15,23	growth_hormone-releasing_hormone	75,107	steroids	growth hormone-releasing hormone	MESH:D013256	29446(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of sex steroids on the response of cultured rat pituitary cells to growth_hormone-releasing_hormone and somatostatin .
7905456	0	steroids	99,107	growth_hormone-releasing_hormone	36,68	steroids	growth hormone-releasing hormone	MESH:D013256	29446(Tax:10116)	Chemical	Gene	Control|nmod|START_ENTITY Control|nmod|transcription transcription|nmod|genes genes|compound|END_ENTITY	Control of the transcription of the growth_hormone-releasing_hormone and somatostatin genes by sex steroids .
2327831	0	steroids	11,19	hCG	80,83	steroids	hCG	MESH:D013256	93659	Chemical	Gene	START_ENTITY|nmod|injection injection|nmod|END_ENTITY	Testicular steroids in spermatic and peripheral veins after single injection of hCG in patients with varicocele .
15831511	0	steroids	115,123	hepatocyte_growth_factor	79,103	steroids	hepatocyte growth factor	MESH:D013256	3082	Chemical	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Estrogen and progesterone_receptor expression in macrophages and regulation of hepatocyte_growth_factor by ovarian steroids in women with endometriosis .
17913526	0	steroids	69,77	iNOS	14,18	steroids	iNOS	MESH:D013256	4843	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|expression expression|amod|END_ENTITY	Inhibition of iNOS expression and NO production by anti-inflammatory steroids .
2967196	0	steroids	8,16	interleukin-1	41,54	steroids	interleukin-1	MESH:D013256	3552	Chemical	Gene	modulate|nsubj|START_ENTITY modulate|dobj|activity activity|amod|END_ENTITY	Gonadal steroids modulate human monocyte interleukin-1 -LRB- IL-1 -RRB- activity .
22226936	0	steroids	63,71	interleukin-18	104,118	steroids	interleukin-18	MESH:D013256	100861190	Chemical	Gene	START_ENTITY|nmod|release release|amod|END_ENTITY	Stromal-epithelial interactions modulate the effect of ovarian steroids on goat uterine epithelial cell interleukin-18 release .
15001649	0	steroids	34,42	interleukin-8	46,59	steroids	interleukin-8	MESH:D013256	3576	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effects of thrombin , hypoxia , and steroids on interleukin-8 expression in decidualized human endometrial stromal cells : implications for long-term progestin-only contraceptive-induced bleeding .
16821206	0	steroids	27,35	leptin	72,78	steroids	leptin	MESH:D013256	3952	Chemical	Gene	exert|nsubj|START_ENTITY exert|nmod|level level|compound|END_ENTITY	Age , insulin , SHBG and sex steroids exert secondary influence on plasma leptin level in women .
23153703	0	steroids	33,41	leptin	45,51	steroids	leptin	MESH:D013256	3952	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Direct in vitro effect of LH and steroids on leptin gene expression and leptin secretion by porcine luteal cells during the mid-luteal phase of the estrous cycle .
11039223	0	steroids	129,137	matrix_metalloproteinase-1	4,30	steroids	matrix metalloproteinase-1	MESH:D013256	4312	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	The matrix_metalloproteinase-1 -LRB- MMP-1 -RRB- expression in the human endometrium is inversely regulated by interleukin-1_alpha and sex steroids .
16191269	0	steroids	31,39	matrix_metalloproteinase-9	57,83	steroids	matrix metalloproteinase-9	MESH:D013256	81687(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Regulatory effects of inhaled steroids on expression of matrix_metalloproteinase-9 and its inhibitor in asthmatic rats -RSB- .
15304209	0	steroids	135,143	neuropeptide_Y	14,28	steroids	neuropeptide Y	MESH:D013256	109648(Tax:10090)	Chemical	Gene	increased|nmod|START_ENTITY increased|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of neuropeptide_Y is increased in murine endometrial epithelium during the peri-implantation period under regulation by sex steroids .
9266547	0	steroids	96,104	oxytocin	45,53	steroids	oxytocin	MESH:D013256	5020	Chemical	Gene	role|nmod|START_ENTITY effects|dep|role effects|nmod|END_ENTITY	Interleukin-1_beta-induced effects on plasma oxytocin and arginine_vasopressin : role of adrenal steroids and route of administration .
23690336	0	steroids	23,31	pituitary_adenylate_cyclase-activating_polypeptide	70,120	steroids	pituitary adenylate cyclase-activating polypeptide	MESH:D013256	24166(Tax:10116)	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of gonadal steroids and gonadotropin-releasing_hormone on pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- and PACAP receptor expression in cultured rat anterior pituitary cells .
12711006	0	steroids	19,27	platelet-derived_endothelial_cell_growth_factor	31,78	steroids	platelet-derived endothelial cell growth factor	MESH:D013256	1890	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of various steroids on platelet-derived_endothelial_cell_growth_factor -LRB- PD-ECGF -RRB- and its mRNA expression in uterine_endometrial_cancer cells .
10320829	0	steroids	48,56	pro-opiomelanocortin	96,116	steroids	pro-opiomelanocortin	MESH:D013256	24664(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Differential involvement of adrenal and gonadal steroids in anterior and intermediate pituitary pro-opiomelanocortin mRNA expression induced by the endogenous benzodiazepine , octadecaneuropeptide , in adult male rats .
2460751	0	steroids	8,16	proenkephalin	26,39	steroids	proenkephalin	MESH:D013256	29237(Tax:10116)	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|amod|END_ENTITY	Gonadal steroids regulate proenkephalin gene expression in a tissue-specific manner within the female reproductive system .
7750466	0	steroids	109,117	proenkephalin	13,26	steroids	proenkephalin	MESH:D013256	29237(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY Induction|dep|role Induction|nmod|END_ENTITY	Induction of proenkephalin in tuberoinfundibular dopaminergic neurons by hyperprolactinemia : the role of sex steroids .
12798354	0	steroids	63,71	progesterone_receptor	14,35	steroids	progesterone receptor	MESH:D013256	25154(Tax:10116)	Chemical	Gene	isoforms|nmod|START_ENTITY isoforms|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of progesterone_receptor isoforms expression by sex steroids in the rat lung .
14695685	0	steroids	18,26	progesterone_receptor	30,51	steroids	progesterone receptor	MESH:D013256	101953815	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of gonadal steroids on progesterone_receptor , estrogen receptor , and vitellogenin expression in male turtles -LRB- Chrysemys_picta -RRB- .
19253100	0	steroids	38,46	progesterone_receptor	62,83	steroids	progesterone receptor	MESH:D013256	5241	Chemical	Gene	class|nmod|START_ENTITY uses|nmod|class uses|dep|END_ENTITY	Gynaecological uses of a new class of steroids : the selective progesterone_receptor modulators .
19456372	0	steroids	83,91	progesterone_receptor	37,58	steroids	progesterone receptor	MESH:D013256	5241	Chemical	Gene	relationship|nmod|START_ENTITY END_ENTITY|dep|relationship	The amphibian -LRB- Rana esculenta -RRB- brain progesterone_receptor : relationship to plasma steroids and vitellogenic cycle during the gonadal recovery phase .
2961153	0	steroids	69,77	progesterone_receptor	93,114	steroids	progesterone receptor	MESH:D013256	5241	Chemical	Gene	relationships|nmod|START_ENTITY calculations|nmod|relationships calculations|amod|binding binding|nmod|END_ENTITY	MTD calculations on quantitative structure-activity relationships of steroids binding to the progesterone_receptor .
8692017	0	steroids	188,196	proinsulin	16,26	steroids	proinsulin	MESH:D013256	3630	Chemical	Gene	influence|nmod|START_ENTITY influence|nmod|END_ENTITY	No influence of proinsulin and insulin on plasma levels of plasminogen_activator_inhibitor_type_1 and tissue_plasminogen_activator in young women before and during intake of contraceptive steroids .
1012438	0	steroids	82,90	prolactin	53,62	steroids	prolactin	MESH:D013256	24683(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|role role|nmod|afferents afferents|nmod|release release|nmod|END_ENTITY	The role of hypothalamic afferents in the release of prolactin induced by ovarian steroids .
17076769	0	steroids	8,16	prolactin	69,78	steroids	prolactin	MESH:D013256	24683(Tax:10116)	Chemical	Gene	regulate|nsubj|START_ENTITY regulate|dobj|secretion secretion|compound|END_ENTITY	Ovarian steroids but not the locus coeruleus regulate stress-induced prolactin secretion in female rats .
180740	0	steroids	22,30	prolactin	83,92	steroids	prolactin	MESH:D013256	5617	Chemical	Gene	synthesis|nmod|START_ENTITY effect|nmod|synthesis effect|nmod|hormones hormones|compound|END_ENTITY	In vitro synthesis of steroids by a feminising adrenocortical_carcinoma : effect of prolactin and other protein hormones .
1910137	0	steroids	90,98	prolactin	58,67	steroids	prolactin	MESH:D013256	707052(Tax:9544)	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|modulation modulation|nmod|END_ENTITY	Possible modulation of N-methyl-D , L-aspartic_acid induced prolactin release by testicular steroids in the adult male rhesus_monkey .
2298160	0	steroids	18,26	prolactin	51,60	steroids	prolactin	MESH:D013256	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|surge surge|nmod|secretion secretion|compound|END_ENTITY	Effect of ovarian steroids on a nocturnal surge of prolactin secretion that precedes parturition in the rat .
2327450	0	steroids	77,85	prolactin	22,31	steroids	prolactin	MESH:D013256	5617	Chemical	Gene	activity|nmod|START_ENTITY proliferative|nsubj|activity proliferative|nmod|induction induction|nmod|production production|compound|END_ENTITY	In vitro induction of prolactin production and aromatase activity by gonadal steroids exclusively in the stroma of separated proliferative human endometrium .
2995857	0	steroids	4,12	prolactin	22,31	steroids	prolactin	MESH:D013256	5617	Chemical	Gene	modulate|nsubj|START_ENTITY modulate|dobj|response response|compound|END_ENTITY	Sex steroids modulate prolactin response to naloxone in postmenopausal women .
328335	0	steroids	30,38	prolactin	129,138	steroids	prolactin	MESH:D013256	5617	Chemical	Gene	effect|nmod|START_ENTITY -LSB-|dobj|effect -RSB-|advcl|-LSB- -RSB-|nsubj|2-bromo-ergokryptin 2-bromo-ergokryptin|dep|concentration concentration|nmod|END_ENTITY	-LSB- The effect of several sexual steroids , 2-bromo-ergokryptin and lisurid-hydrogenmaleate an the postpartum concentration of serum prolactin and lactation -LRB- author 's transl -RRB- -RSB- .
3665121	0	steroids	16,24	prolactin	58,67	steroids	prolactin	MESH:D013256	5617	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|control control|nmod|secretion secretion|compound|END_ENTITY	Role of gonadal steroids in the serotoninergic control of prolactin secretion in men .
3998656	0	steroids	74,82	prolactin	14,23	steroids	prolactin	MESH:D013256	24683(Tax:10116)	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|Alteration Alteration|nmod|control control|compound|END_ENTITY	Alteration of prolactin control in adult rats treated neonatally with sex steroids .
6694510	0	steroids	14,22	prolactin	62,71	steroids	prolactin	MESH:D013256	24683(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of steroids on the size heterogeneity of pituitary prolactin in castrate male rats .
7316459	0	steroids	14,22	prolactin	46,55	steroids	prolactin	MESH:D013256	5617	Chemical	Gene	START_ENTITY|nmod|level level|compound|END_ENTITY	Effect of sex steroids on pituitary and serum prolactin level in ovariectomized catfish , Clarias batrachus .
7472275	0	steroids	4,12	prolactin	22,31	steroids	prolactin	MESH:D013256	5617	Chemical	Gene	modulate|nsubj|START_ENTITY modulate|dobj|action action|compound|END_ENTITY	Sex steroids modulate prolactin action in spontaneously luteinizing porcine granulosa cells in vitro .
826392	0	steroids	15,23	prolactin	27,36	steroids	prolactin	MESH:D013256	24683(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|cells cells|amod|END_ENTITY	Effects of sex steroids on prolactin secreting rat pituitary cells in culture .
8318580	0	steroids	16,24	prolactin	69,78	steroids	prolactin	MESH:D013256	280901(Tax:9913)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of ovarian steroids in development of uterine binding sites for prolactin in the ferret .
9423931	0	steroids	45,53	prolactin	14,23	steroids	prolactin	MESH:D013256	24683(Tax:10116)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Regulation of prolactin secretion by adrenal steroids in oestrogen-treated ovariectomized rats : participation of endogenous opioid peptides .
20499362	0	steroids	51,59	sclerostin	26,36	steroids	sclerostin	MESH:D013256	50964	Chemical	Gene	circulating|nmod|START_ENTITY circulating|dobj|levels levels|compound|END_ENTITY	Regulation of circulating sclerostin levels by sex steroids in women and in men .
23429230	0	steroids	15,23	sclerostin	33,43	steroids	sclerostin	MESH:D013256	50964	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|compound|END_ENTITY	Effects of sex steroids on serum sclerostin levels during the menstrual cycle .
12208668	0	steroids	13,21	secretogranin_II	64,80	steroids	secretogranin II	MESH:D013256	20254(Tax:10090)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of steroids and GnRH on biosynthesis and secretion of secretogranin_II and chromogranin_A in relation to LH release in LbetaT2 gonadotroph cells .
6215421	0	steroids	18,26	somatomedin_C	58,71	steroids	somatomedin C	MESH:D013256	3479	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|concentrations concentrations|compound|END_ENTITY	The effect of sex steroids on radioimmunoassayable plasma somatomedin_C concentrations .
6542483	0	steroids	35,43	tissue-type_plasminogen_activator	62,95	steroids	tissue-type plasminogen activator	MESH:D013256	5327	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|release release|nmod|END_ENTITY	Regulatory effect of contraceptive steroids on the release of tissue-type_plasminogen_activator in vitro .
6890091	0	steroids	18,26	vasopressin	30,41	steroids	vasopressin	MESH:D013256	551	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of ovarian steroids on vasopressin secretion .
11901146	0	sterol	35,41	ABCG5	55,60	sterol	ABCG5	CHEBI:15889	27409(Tax:10090)	Chemical	Gene	Regulation|nmod|START_ENTITY transporters|nsubj|Regulation transporters|dobj|END_ENTITY	Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta .
15044450	0	sterol	63,69	ABCG5	8,13	sterol	ABCG5	CHEBI:15889	27409(Tax:10090)	Chemical	Gene	transport|amod|START_ENTITY increases|dobj|transport increases|nsubj|END_ENTITY	Hepatic ABCG5 and ABCG8 overexpression increases hepatobiliary sterol transport but does not alter aortic_atherosclerosis in transgenic_mice .
16428624	0	sterol	77,83	ABCG5	97,102	sterol	ABCG5	CHEBI:15889	515536(Tax:9913)	Chemical	Gene	analysis|nmod|START_ENTITY Identification|appos|analysis transporters|nsubj|Identification transporters|dobj|END_ENTITY	Identification , sequence analysis and mRNA tissue distribution of the bovine sterol transporters ABCG5 and ABCG8 .
17403900	0	sterol	128,134	ABCG5	148,153	sterol	ABCG5	CHEBI:15889	64240	Chemical	Gene	transporters|compound|START_ENTITY END_ENTITY|nsubj|transporters	Cooperative interaction between hepatocyte_nuclear_factor_4_alpha and GATA transcription factors regulates ATP-binding cassette sterol transporters ABCG5 and ABCG8 .
17459188	0	sterol	38,44	ABCG5	74,79	sterol	ABCG5	CHEBI:15889	101827940	Chemical	Gene	analogues|compound|START_ENTITY effects|nmod|analogues independent|nsubj|effects independent|nmod|expressions expressions|compound|END_ENTITY	Hypocholesterolaemic effects of plant sterol analogues are independent of ABCG5 and ABCG8 transporter expressions in hamsters .
18402465	0	sterol	35,41	ABCG5	67,72	sterol	ABCG5	CHEBI:15889	27409(Tax:10090)	Chemical	Gene	transfer|amod|START_ENTITY Purification|nmod|transfer Purification|nmod|END_ENTITY	Purification and reconstitution of sterol transfer by native mouse ABCG5 and ABCG8 .
19306529	0	sterol	16,22	ABCG5	4,9	sterol	ABCG5	CHEBI:15889	27409(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	The ABCG5 ABCG8 sterol transporter and phytosterols : implications for cardiometabolic_disease .
22715101	0	sterol	16,22	ABCG5	4,9	sterol	ABCG5	CHEBI:15889	27409(Tax:10090)	Chemical	Gene	transporter|amod|START_ENTITY transporter|compound|END_ENTITY	The ABCG5 ABCG8 sterol transporter opposes the development of fatty_liver_disease and loss of glycemic control independently of phytosterol accumulation .
23790976	0	sterol	63,69	ABCG5	83,88	sterol	ABCG5	CHEBI:15889	64240	Chemical	Gene	activation|nmod|START_ENTITY transporters|nsubj|activation transporters|dobj|genes genes|compound|END_ENTITY	Cooperative transcriptional activation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 genes by nuclear receptors including Liver-X-Receptor .
26365598	0	sterol	30,36	ABCG5	18,23	sterol	ABCG5	CHEBI:15889	27409(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	GRP78 rescues the ABCG5 ABCG8 sterol transporter in db/db mice .
15520451	0	sterol	57,63	ABCG8	30,35	sterol	ABCG8	CHEBI:15889	64241	Chemical	Gene	metabolism|amod|START_ENTITY plant|dobj|metabolism related|xcomp|plant related|nsubjpass|variations variations|nmod|END_ENTITY	Common sequence variations in ABCG8 are related to plant sterol metabolism in healthy volunteers .
19306529	0	sterol	16,22	ABCG8	10,15	sterol	ABCG8	CHEBI:15889	67470(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	The ABCG5 ABCG8 sterol transporter and phytosterols : implications for cardiometabolic_disease .
22715101	0	sterol	16,22	ABCG8	10,15	sterol	ABCG8	CHEBI:15889	67470(Tax:10090)	Chemical	Gene	transporter|amod|START_ENTITY transporter|compound|END_ENTITY	The ABCG5 ABCG8 sterol transporter opposes the development of fatty_liver_disease and loss of glycemic control independently of phytosterol accumulation .
26365598	0	sterol	30,36	ABCG8	24,29	sterol	ABCG8	CHEBI:15889	67470(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	GRP78 rescues the ABCG5 ABCG8 sterol transporter in db/db mice .
25891779	0	sterol	115,121	AMP-activated_protein_kinase	86,114	sterol	AMP-activated protein kinase	CHEBI:15889	5563	Chemical	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	Metformin attenuates palmitic_acid-induced insulin resistance in L6 cells through the AMP-activated_protein_kinase / sterol regulatory element-binding protein-1c pathway .
22095132	0	sterol	64,70	ATP_binding_cassette_transporter_G1	0,35	sterol	ATP binding cassette transporter G1	CHEBI:15889	9619	Chemical	Gene	transporter|compound|START_ENTITY transporter|nsubj|END_ENTITY	ATP_binding_cassette_transporter_G1 -LRB- ABCG1 -RRB- is an intracellular sterol transporter .
14618236	0	sterol	93,99	Abcg5	42,47	sterol	Abcg5	CHEBI:15889	114628(Tax:10116)	Chemical	Gene	fluxes|amod|START_ENTITY associated|nmod|fluxes associated|nsubj|Down-regulation Down-regulation|nmod|END_ENTITY	Down-regulation of hepatic and intestinal Abcg5 and Abcg8 expression associated with altered sterol fluxes in rats with streptozotocin-induced diabetes .
9862498	0	sterol	140,146	C-8	134,137	sterol	C-8	CHEBI:15889	14793(Tax:10090)	Chemical	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	Isolation and characterization of an Arabidopsis_thaliana C-8 ,7 sterol isomerase : functional and structural similarities to mammalian C-8 ,7 sterol isomerase/emopamil-binding _ protein .
12145339	0	sterol	56,62	CYP51	124,129	sterol	CYP51	CHEBI:15889	1595	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|gene gene|appos|END_ENTITY	A cAMP-responsive element binding site is essential for sterol regulation of the human lanosterol_14alpha-demethylase gene -LRB- CYP51 -RRB- .
20050180	0	sterol	14,20	Cdc42p	40,46	sterol	Cdc42p	CHEBI:15889	850930(Tax:4932)	Chemical	Gene	homeostasis|amod|START_ENTITY homeostasis|nmod|END_ENTITY	Modulation of sterol homeostasis by the Cdc42p effectors Cla4p and Ste20p in the yeast Saccharomyces_cerevisiae .
22252807	0	sterol	44,50	ERG3	78,82	sterol	ERG3	CHEBI:15889	170738(Tax:10090)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Azole resistance by loss of function of the sterol / \ , - desaturase gene -LRB- ERG3 -RRB- in Candida_albicans does not necessarily decrease virulence .
8772195	0	sterol	38,44	ERG3	64,68	sterol	ERG3	CHEBI:15889	850745(Tax:4932)	Chemical	Gene	gene|amod|START_ENTITY regulation|nmod|gene regulation|appos|END_ENTITY	Positive and negative regulation of a sterol biosynthetic gene -LRB- ERG3 -RRB- in the post-squalene portion of the yeast ergosterol pathway .
9593144	0	sterol	69,75	ERG6	95,99	sterol	ERG6	CHEBI:15889	855003(Tax:4932)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Sequencing , disruption , and characterization of the Candida_albicans sterol methyltransferase -LRB- ERG6 -RRB- gene : drug susceptibility studies in erg6 mutants .
11530940	0	sterol	19,25	FAS	42,45	sterol	FAS	CHEBI:15889	2194	Chemical	Gene	response|amod|START_ENTITY response|nmod|promoter promoter|compound|END_ENTITY	The FIRE3-mediated sterol response of the FAS promoter requires NF-Y/CBF as a coactivator .
9632664	0	sterol	21,27	HLH106	0,6	sterol	HLH106	CHEBI:15889	40155(Tax:7227)	Chemical	Gene	protein|amod|START_ENTITY END_ENTITY|appos|protein	HLH106 , a Drosophila sterol regulatory element-binding protein in a natural cholesterol auxotroph .
16601238	0	sterol	83,89	Keratinocyte_growth_factor	0,26	sterol	Keratinocyte growth factor	CHEBI:15889	29348(Tax:10116)	Chemical	Gene	pathway|amod|START_ENTITY induces|nmod|pathway induces|nsubj|END_ENTITY	Keratinocyte_growth_factor induces lipogenesis in alveolar type II cells through a sterol regulatory element binding protein-1c-dependent pathway .
25987606	0	sterol	24,30	Ltc1	0,4	sterol	Ltc1	CHEBI:15889	850761(Tax:4932)	Chemical	Gene	transporter|amod|START_ENTITY transporter|nsubj|END_ENTITY	Ltc1 is an ER-localized sterol transporter and a component of ER-mitochondria and ER-vacuole contacts .
25987606	0	sterol	24,30	Ltc1	0,4	sterol	Ltc1	CHEBI:15889	850761(Tax:4932)	Chemical	Gene	transporter|amod|START_ENTITY transporter|nsubj|END_ENTITY	Ltc1 is an ER-localized sterol transporter and a component of ER-mitochondria and ER-vacuole contacts .
17008555	0	sterol	62,68	Niemann-Pick_C1-like_1	20,42	sterol	Niemann-Pick C1-like 1	CHEBI:15889	29881	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Modulation of human Niemann-Pick_C1-like_1 gene expression by sterol : Role of sterol regulatory element binding protein 2 .
17008555	0	sterol	78,84	Niemann-Pick_C1-like_1	20,42	sterol	Niemann-Pick C1-like 1	CHEBI:15889	29881	Chemical	Gene	element|amod|START_ENTITY Role|nmod|element Modulation|dep|Role Modulation|nmod|expression expression|compound|END_ENTITY	Modulation of human Niemann-Pick_C1-like_1 gene expression by sterol : Role of sterol regulatory element binding protein 2 .
19224871	0	sterol	28,34	OSBP-related_protein_2	0,22	sterol	OSBP-related protein 2	CHEBI:15889	9885	Chemical	Gene	receptor|amod|START_ENTITY receptor|nsubj|END_ENTITY	OSBP-related_protein_2 is a sterol receptor on lipid droplets that regulates the metabolism of neutral lipids .
25255026	0	sterol	24,30	OSBP-related_protein_9	107,129	sterol	OSBP-related protein 9	CHEBI:15889	114883	Chemical	Gene	properties|amod|START_ENTITY properties|nmod|END_ENTITY	Characterization of the sterol and phosphatidylinositol 4-phosphate binding properties of Golgi-associated OSBP-related_protein_9 -LRB- ORP9 -RRB- .
2280670	2	sterol	462,468	SCP2	299,303	sterol	FABP	CHEBI:15889	2806	Chemical	Gene	exchange|amod|START_ENTITY rate|nmod|exchange 2.3-fold|nsubj|rate enhanced|xcomp|2.3-fold enhanced|nsubj|END_ENTITY	Sterol_carrier_protein-2 -LRB- SCP2 , also called nonspecific lipid transfer protein -RRB- , but not fatty_acid binding protein -LRB- FABP , also called sterol carrier protein -RRB- , enhanced the initial rate of sterol exchange between neutral zwitterionic phosphatidylcholine small unilamellar vesicles -LRB- SUV -RRB- 2.3-fold .
3395344	0	sterol	47,53	SCP2	70,74	sterol	SCP2	CHEBI:15889	25541(Tax:10116)	Chemical	Gene	protein|amod|START_ENTITY structure|nmod|protein study|nmod|structure END_ENTITY|nsubj|study	A mass spectrometric study of the structure of sterol carrier protein SCP2 from rat liver .
18192539	0	sterol	31,37	SREBF1	75,81	sterol	SREBF1	CHEBI:15889	6720	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Association of variants in the sterol regulatory element-binding factor 1 -LRB- SREBF1 -RRB- gene with type 2 diabetes , glycemia , and insulin resistance : a study of 15,734 Danish subjects .
11090130	0	sterol	20,26	SREBP-1c	71,79	sterol	SREBP-1c	CHEBI:15889	20787(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|gene gene|appos|END_ENTITY	Regulation of mouse sterol regulatory element-binding protein-1c gene -LRB- SREBP-1c -RRB- by oxysterol receptors , LXRalpha and LXRbeta .
16705668	0	sterol	58,64	SREBP-2	101,108	sterol	SREBP-2	CHEBI:15889	300095(Tax:10116)	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Gender-related difference in altered gene expression of a sterol regulatory element binding protein , SREBP-2 , by lead nitrate in rats : correlation with development of hypercholesterolemia .
20138239	0	sterol	58,64	SREBP-2	33,40	sterol	SREBP-2	CHEBI:15889	6721	Chemical	Gene	element|amod|START_ENTITY depends|nmod|element depends|nsubj|Activation Activation|nmod|promoter promoter|nmod|END_ENTITY	Activation of TM7SF2 promoter by SREBP-2 depends on a new sterol regulatory element , a GC-box , and an inverted CCAAT-box .
20566875	0	sterol	48,54	SREBP-2	13,20	sterol	SREBP-2	CHEBI:15889	6721	Chemical	Gene	transporters|amod|START_ENTITY repression|nmod|transporters END_ENTITY|nmod|repression	miR-33 links SREBP-2 induction to repression of sterol transporters .
7903453	0	sterol	110,116	SREBP-2	0,7	sterol	SREBP-2	CHEBI:15889	6721	Chemical	Gene	element|amod|START_ENTITY binding|nmod|element stimulates|nmod|binding protein|acl:relcl|stimulates END_ENTITY|appos|protein	SREBP-2 , a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element .
8751375	0	sterol	51,57	Scp2	82,86	sterol	Scp2	CHEBI:15889	20280(Tax:10090)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Structure and chromosomal assignment of the murine sterol carrier protein 2 gene -LRB- Scp2 -RRB- and two related pseudogenes by in situ hybridization .
19500568	0	sterol	59,65	Srd5a2	48,54	sterol	Srd5a2	CHEBI:15889	94224(Tax:10090)	Chemical	Gene	element|amod|START_ENTITY END_ENTITY|nmod|element	Regulation of steroid_5-alpha_reductase_type_2 -LRB- Srd5a2 -RRB- by sterol regulatory element binding proteins and statin .
15564601	0	sterol	27,33	Stard6	50,56	sterol	Stard6	CHEBI:15889	291527(Tax:10116)	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Expression of the putative sterol binding protein Stard6 gene is male germ cell specific .
9756854	0	sterol	51,57	Steroidogenic_acute_regulatory_protein	0,38	sterol	Steroidogenic acute regulatory protein	CHEBI:15889	6770	Chemical	Gene	protein|amod|START_ENTITY protein|nsubj|END_ENTITY	Steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- is a sterol transfer protein .
20138239	0	sterol	58,64	TM7SF2	14,20	sterol	TM7SF2	CHEBI:15889	7108	Chemical	Gene	element|amod|START_ENTITY depends|nmod|element depends|nsubj|Activation Activation|nmod|promoter promoter|nummod|END_ENTITY	Activation of TM7SF2 promoter by SREBP-2 depends on a new sterol regulatory element , a GC-box , and an inverted CCAAT-box .
20659465	0	sterol	36,42	abcg8	66,71	sterol	abcg8	CHEBI:15889	67470(Tax:10090)	Chemical	Gene	excretion|amod|START_ENTITY stimulates|dobj|excretion stimulates|advcl|function function|amod|END_ENTITY	Ezetimibe stimulates faecal neutral sterol excretion depending on abcg8 function in mice .
9593144	0	sterol	69,75	erg6	138,142	sterol	erg6	CHEBI:15889	855003(Tax:4932)	Chemical	Gene	gene|amod|START_ENTITY Sequencing|nmod|gene Sequencing|dep|studies studies|nmod|mutants mutants|amod|END_ENTITY	Sequencing , disruption , and characterization of the Candida_albicans sterol methyltransferase -LRB- ERG6 -RRB- gene : drug susceptibility studies in erg6 mutants .
213333	0	sterol	38,44	glucagon	26,34	sterol	glucagon	CHEBI:15889	24952(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY END_ENTITY|nmod|synthesis	Relative insensitivity to glucagon of sterol synthesis in cultured rat aortic smooth muscle cells .
10224053	0	sterol	72,78	low_density_lipoprotein_receptor	31,63	sterol	low density lipoprotein receptor	CHEBI:15889	3949	Chemical	Gene	protein|amod|START_ENTITY gene|nmod|protein gene|compound|END_ENTITY	Co-stimulation of promoter for low_density_lipoprotein_receptor gene by sterol regulatory element-binding protein and Sp1 is specifically disrupted by the yin_yang_1 protein .
11795856	0	sterol	54,60	low_density_lipoprotein_receptor	21,53	sterol	low density lipoprotein receptor	CHEBI:15889	3949	Chemical	Gene	START_ENTITY|nsubj|modulation modulation|nmod|END_ENTITY	Growth modulation of low_density_lipoprotein_receptor sterol sensitivity in cultured human fibroblasts .
22153697	0	sterol	142,148	low_density_lipoprotein_receptor	57,89	sterol	low density lipoprotein receptor	CHEBI:15889	3949	Chemical	Gene	proteins|amod|START_ENTITY activation|nmod|proteins increases|nmod|activation increases|dobj|expression expression|nmod|END_ENTITY	Resveratrol increases the expression and activity of the low_density_lipoprotein_receptor in hepatocytes by the proteolytic activation of the sterol regulatory element-binding proteins .
2298751	0	sterol	67,73	low_density_lipoprotein_receptor	96,128	sterol	low density lipoprotein receptor	CHEBI:15889	3949	Chemical	Gene	element|amod|START_ENTITY element|nmod|gene gene|compound|END_ENTITY	Identification of nucleotides responsible for enhancer activity of sterol regulatory element in low_density_lipoprotein_receptor gene .
7597088	0	sterol	77,83	low_density_lipoprotein_receptor	124,156	sterol	low density lipoprotein receptor	CHEBI:15889	3949	Chemical	Gene	element|amod|START_ENTITY required|nmod|element required|dobj|protein protein|nmod|promoter promoter|compound|END_ENTITY	Domains of transcription factor Sp1 required for synergistic activation with sterol regulatory element binding protein 1 of low_density_lipoprotein_receptor promoter .
7836375	0	sterol	68,74	low_density_lipoprotein_receptor	89,121	sterol	low density lipoprotein receptor	CHEBI:15889	43105(Tax:7227)	Chemical	Gene	regulation|amod|START_ENTITY Cooperation|nmod|regulation Cooperation|nmod|gene gene|compound|END_ENTITY	Cooperation by sterol_regulatory_element-binding_protein and Sp1 in sterol regulation of low_density_lipoprotein_receptor gene .
8390995	0	sterol	27,33	low_density_lipoprotein_receptor	56,88	sterol	low density lipoprotein receptor	CHEBI:15889	300438(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|element element|nmod|promoter promoter|compound|END_ENTITY	Nuclear protein that binds sterol regulatory element of low_density_lipoprotein_receptor promoter .
9717725	0	sterol	20,26	low_density_lipoprotein_receptor	69,101	sterol	low density lipoprotein receptor	CHEBI:15889	3949	Chemical	Gene	element-dependent|amod|START_ENTITY Sterol-independent|appos|element-dependent Sterol-independent|appos|regulation regulation|nmod|expression expression|compound|END_ENTITY	Sterol-independent , sterol response element-dependent , regulation of low_density_lipoprotein_receptor gene expression .
19720801	0	sterol	154,160	myocyte_enhancer_factor_2C	199,225	sterol	myocyte enhancer factor 2C	CHEBI:15889	4208	Chemical	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	The microRNA signature in response to insulin reveals its implication in the transcriptional action of insulin in human skeletal muscle and the role of a sterol regulatory element-binding protein-1c / myocyte_enhancer_factor_2C pathway .
9915808	0	sterol	92,98	peroxisome_proliferator-activated_receptor_alpha	28,76	sterol	peroxisome proliferator-activated receptor alpha	CHEBI:15889	19013(Tax:10090)	Chemical	Gene	carrier|amod|START_ENTITY END_ENTITY|nmod|carrier	Phytanic_acid activates the peroxisome_proliferator-activated_receptor_alpha -LRB- PPARalpha -RRB- in sterol carrier protein 2 - / sterol_carrier_protein_x-deficient mice .
15450207	0	sterol	55,61	phospholipase_A2	24,40	sterol	phospholipase A2	CHEBI:15889	100764593	Chemical	Gene	availability|amod|START_ENTITY VIA|nmod|availability VIA|dobj|expression expression|amod|END_ENTITY	Regulation of group VIA phospholipase_A2 expression by sterol availability .
11893773	0	sterol	15,21	scavenger_receptor_class_B_type_I	62,95	sterol	scavenger receptor class B type I	CHEBI:15889	20778(Tax:10090)	Chemical	Gene	efflux|amod|START_ENTITY modulated|nsubjpass|efflux modulated|nmod|expression expression|amod|END_ENTITY	ApoE-dependent sterol efflux from macrophages is modulated by scavenger_receptor_class_B_type_I expression .
6497882	0	sterol	80,86	sterol_carrier_protein	37,59	sterol	sterol carrier protein	CHEBI:15889	55974	Chemical	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	Correlation of tumor metastasis with sterol_carrier_protein and plasma membrane sterol levels .
11145566	0	sterol	167,173	sterol_regulatory_element_binding_protein	118,159	sterol	sterol regulatory element binding protein	CHEBI:15889	7555	Chemical	Gene	element|amod|START_ENTITY END_ENTITY|nmod|element	Yin_yang_1 protein negatively regulates high-density lipoprotein receptor gene transcription by disrupting binding of sterol_regulatory_element_binding_protein to the sterol regulatory element .
6987395	0	sterol_sulphates	29,45	acrosin	18,25	sterol sulphates	acrosin	null	49	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	The inhibition of acrosin by sterol_sulphates .
12406021	0	sterols	64,71	Apolipoprotein_E	0,16	sterols	Apolipoprotein E	MESH:D013261	348	Chemical	Gene	START_ENTITY|nsubj|polymorphism polymorphism|amod|END_ENTITY	Apolipoprotein_E polymorphism and serum lipid response to plant sterols in humans .
21110944	0	sterols	68,75	Aus1p	25,30	sterols	Aus1p	MESH:D013261	854175(Tax:4932)	Chemical	Gene	uptake|nmod|START_ENTITY END_ENTITY|nmod|uptake	The role of ABC proteins Aus1p and Pdr11p in the uptake of external sterols in yeast : dehydroergosterol fluorescence study .
15246101	0	sterols	6,13	DNA_polymerase_beta	27,46	sterols	DNA polymerase beta	MESH:D013261	5423	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Plant sterols as selective DNA_polymerase_beta lyase inhibitors and potentiators of bleomycin cytotoxicity .
11090277	0	sterols	36,43	LPL	13,16	sterols	LPL	MESH:D013261	4023	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Induction of LPL gene expression by sterols is mediated by a sterol regulatory element and is independent of the presence of multiple E boxes .
1369463	0	sterols	81,88	P-glycoprotein	108,122	sterols	P-glycoprotein	MESH:D013261	5243	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	Expression of human P-glycoprotein in yeast cells -- effects of membrane component sterols on the activity of P-glycoprotein .
1369463	0	sterols	81,88	P-glycoprotein	20,34	sterols	P-glycoprotein	MESH:D013261	5243	Chemical	Gene	effects|nmod|START_ENTITY Expression|dep|effects Expression|nmod|END_ENTITY	Expression of human P-glycoprotein in yeast cells -- effects of membrane component sterols on the activity of P-glycoprotein .
8228636	0	sterols	53,60	apoE	109,113	sterols	apoE	MESH:D013261	348	Chemical	Gene	START_ENTITY|nmod|subjects subjects|nmod|END_ENTITY	Serum cholesterol , cholesterol precursors , and plant sterols in hypercholesterolemic subjects with different apoE phenotypes during dietary sitostanol_ester treatment .
18066136	0	sterols	104,111	apolipoprotein_A1_and_B	14,37	sterols	apolipoprotein A1 and B	MESH:D013261	338	Chemical	Gene	START_ENTITY|nsubj|Modulation Modulation|nmod|END_ENTITY	Modulation of apolipoprotein_A1_and_B , adiponectin , ghrelin , and growth_hormone concentrations by plant sterols and exercise in previously sedentary humans .
7665995	0	sterols	60,67	cholesterol_7_alpha-hydroxylase	14,45	sterols	cholesterol 7 alpha-hydroxylase	MESH:D013261	25428(Tax:10116)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of cholesterol_7_alpha-hydroxylase expression by sterols in primary rat hepatocyte cultures .
8626488	0	sterols	52,59	squalene_epoxidase	30,48	sterols	squalene epoxidase	MESH:D013261	6713	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of squalene_epoxidase by sterols and inhibitors in HeLa cells .
10672016	0	steryl_ester	35,47	Are1p	16,21	steryl ester	Are1p	CHEBI:35915	850415(Tax:4932)	Chemical	Gene	Contribution|acl|START_ENTITY Contribution|nmod|END_ENTITY	Contribution of Are1p and Are2p to steryl_ester synthesis in the yeast Saccharomyces_cerevisiae .
23299431	0	stigmasterol	25,37	AtCYP710A1	0,10	stigmasterol	AtCYP710A1	MESH:D013265	818013(Tax:3702)	Chemical	Gene	production|amod|START_ENTITY production|nummod|END_ENTITY	AtCYP710A1 gene-mediated stigmasterol production plays a role in imparting temperature stress tolerance in Arabidopsis_thaliana .
2843373	0	stigmatellin	25,37	cytochrome_b	53,65	stigmatellin	cytochrome b	MESH:C041573	3283889(Tax:9913)	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	Studies on the effect of stigmatellin derivatives on cytochrome_b and the Rieske iron-sulfur cluster of cytochrome c reductase from bovine heart mitochondria .
15379532	0	stilbene	29,37	AE1	47,50	stilbene	AE1	CHEBI:26775	6521	Chemical	Gene	sites|amod|START_ENTITY sites|nmod|END_ENTITY	Relocation of the disulfonic stilbene sites of AE1 -LRB- band 3 -RRB- on the basis of fluorescence energy transfer measurements .
11720533	0	stilbene	14,22	tyrosinase	28,38	stilbene	tyrosinase	CHEBI:26775	7299	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	A new dimeric stilbene with tyrosinase inhibitiory activity from Artocarpus gomezianus .
12612420	0	stilbene	6,14	tyrosinase	20,30	stilbene	tyrosinase	CHEBI:26775	7299	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	A new stilbene with tyrosinase inhibitory activity from Chlorophora excelsa .
10460174	0	stilbene_disulfonate	26,46	AE1	74,77	stilbene disulfonate	AE1	null	6521	Chemical	Gene	sites|amod|START_ENTITY sites|nmod|END_ENTITY	Binding properties of the stilbene_disulfonate sites on human erythrocyte AE1 : kinetic , thermodynamic , and solid state deuterium NMR analyses .
11599362	0	stilbenes	22,31	Reg	54,57	stilbenes	Reg	MESH:D013267	5967	Chemical	Gene	START_ENTITY|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Chemical research on stilbenes from Veratrum macckii Reg -RSB- .
2004631	0	stiripentol	104,115	cytochrome_P-450	73,89	stiripentol	cytochrome P-450	MESH:C021092	4051	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Carbamazepine dose requirements during stiripentol therapy : influence of cytochrome_P-450 inhibition by stiripentol .
2004631	0	stiripentol	39,50	cytochrome_P-450	73,89	stiripentol	cytochrome P-450	MESH:C021092	4051	Chemical	Gene	therapy|amod|START_ENTITY requirements|nmod|therapy requirements|dep|influence influence|nmod|inhibition inhibition|amod|END_ENTITY	Carbamazepine dose requirements during stiripentol therapy : influence of cytochrome_P-450 inhibition by stiripentol .
3178875	0	stiripentol	61,72	cytochrome_P-450	32,48	stiripentol	cytochrome P-450	MESH:C021092	25251(Tax:10116)	Chemical	Gene	Ex|nmod|START_ENTITY Ex|dobj|inhibition inhibition|nmod|activity activity|amod|END_ENTITY	Ex vivo inhibition of rat brain cytochrome_P-450 activity by stiripentol .
7436632	0	streptomycin	22,34	bradykinin	100,110	streptomycin	bradykinin	MESH:D013307	3827	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Inhibitory effects of streptomycin on bronchoconstrictor , hypotensive and inflammatory responses to bradykinin and histamine .
21189568	0	streptomycin	76,88	iNOS	1,5	streptomycin	iNOS	MESH:D013307	100135576(Tax:10141)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|END_ENTITY	-LSB- iNOS and AChE expression on guinea_pigs cochlea spiral ganglion induced by streptomycin and attenuation by Salvia miltiorrhiza injection -RSB- .
26531813	0	streptozocin	119,131	VCAM-1	109,115	streptozocin	VCAM-1	MESH:D013311	25361(Tax:10116)	Chemical	Gene	rats|amod|START_ENTITY END_ENTITY|nmod|rats	The renoprotective effects of berberine and its potential impact on the expression of b-arrestins and ICAM-1 / VCAM-1 in streptozocin induced-diabetic_nephropathy rats .
179128	0	streptozocin	10,22	gastrin	26,33	streptozocin	gastrin	MESH:D013311	2520	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|release release|compound|END_ENTITY	Effect of streptozocin on gastrin release .
7552296	0	streptozocin	89,101	growth_hormone-releasing_hormone	28,60	streptozocin	growth hormone-releasing hormone	MESH:D013311	29446(Tax:10116)	Chemical	Gene	rats|amod|START_ENTITY END_ENTITY|nmod|rats	Time course of hypothalamic growth_hormone-releasing_hormone and somatostatin content in streptozocin diabetic rats : evidence for early changes in hypothalamic regulation .
19027847	0	streptozotocin	139,153	Akt	101,104	streptozotocin	Akt	MESH:D013311	24185(Tax:10116)	Chemical	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Niacin bound chromium treatment induces myocardial Glut-4 translocation and caveolar interaction via Akt , AMPK and eNOS phosphorylation in streptozotocin induced diabetic rats after ischemia-reperfusion injury .
22001294	0	streptozotocin	118,132	CA1	80,83	streptozotocin	CA1	MESH:D013311	310218(Tax:10116)	Chemical	Gene	region|nmod|START_ENTITY region|compound|END_ENTITY	Differential role of cyclooxygenase isozymes on neuronal density in hippocampus CA1 region of intracerebroventricular streptozotocin treated rat brain .
26490765	1	streptozotocin	121,135	GLUT-2	99,105	streptozotocin	GLUT-2	MESH:D013311	25351(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|END_ENTITY	and its effect on the glucose transport gene -LRB- GLUT-2 and GLUT-4 -RRB- in streptozotocin induced diabetic wistar_rats .
11741307	0	streptozotocin	70,84	GLUT1	28,33	streptozotocin	GLUT1	MESH:D013311	20525(Tax:10090)	Chemical	Gene	sensitivity|nmod|START_ENTITY sensitivity|nmod|cells cells|amod|END_ENTITY	Differential sensitivity of GLUT1 - and GLUT2-expressing beta cells to streptozotocin .
20583965	0	streptozotocin	67,81	GLUT1	26,31	streptozotocin	GLUT1	MESH:D013311	24778(Tax:10116)	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Influence of metformin on GLUT1 gene and protein expression in rat streptozotocin diabetes_mellitus model .
11411796	2	streptozotocin	265,279	GLUT2	339,344	streptozotocin	GLUT2	MESH:D013311	25351(Tax:10116)	Chemical	Gene	injection|nmod|START_ENTITY weeks|nmod|injection needed|nmod|weeks upregulated|ccomp|needed upregulated|nsubjpass|levels levels|nmod|transporter transporter|appos|END_ENTITY	These data are needed because two weeks following injection of streptozotocin -LRB- STZ -RRB- , mRNA and protein levels of the glucose transporter , GLUT2 , are upregulated in the proximal tubule of the rat .
18042662	0	streptozotocin	49,63	GLUT2	91,96	streptozotocin	GLUT2	MESH:D013311	20526(Tax:10090)	Chemical	Gene	START_ENTITY|advcl|activity activity|compound|END_ENTITY	KATP_channel-deficient pancreatic beta-cells are streptozotocin resistant because of lower GLUT2 activity .
25699277	0	streptozotocin	58,72	GLUT2	149,154	streptozotocin	GLUT2	MESH:D013311	20526(Tax:10090)	Chemical	Gene	affected|nmod|START_ENTITY affected|advcl|mice mice|dep|correlations correlations|nmod|expressions expressions|compound|END_ENTITY	Diabetes-resistant NOR mice are more severely affected by streptozotocin compared to the diabetes-prone NOD mice : correlations with liver and kidney GLUT2 expressions .
9421374	0	streptozotocin	99,113	GLUT2	0,5	streptozotocin	GLUT2	MESH:D013311	20526(Tax:10090)	Chemical	Gene	doses|nmod|START_ENTITY induced|nmod|doses diabetes|acl|induced molecule|nmod|diabetes END_ENTITY|dep|molecule	GLUT2 in pancreatic islets : crucial target molecule in diabetes induced with multiple low doses of streptozotocin in mice .
9989930	0	streptozotocin	22,36	GLUT2	157,162	streptozotocin	GLUT2	MESH:D013311	20526(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Inhibitory effects of streptozotocin , tumor_necrosis_factor-alpha , and interleukin-1beta on glucokinase activity in pancreatic islets and gene expression of GLUT2 and glucokinase .
3022736	0	streptozotocin	60,74	Insulin_receptor	0,16	streptozotocin	Insulin receptor	MESH:D013311	24954(Tax:10116)	Chemical	Gene	rats|amod|START_ENTITY END_ENTITY|nmod|rats	Insulin_receptor autophosphorylation and kinase activity in streptozotocin diabetic rats .
20176078	0	streptozotocin	56,70	JNK	8,11	streptozotocin	JNK	MESH:D013311	5599	Chemical	Gene	activation|nmod|START_ENTITY activation|nsubj|Role Role|nmod|END_ENTITY	Role of JNK activation in pancreatic beta-cell death by streptozotocin .
19217614	0	streptozotocin	41,55	O-GlcNAcase	70,81	streptozotocin	O-GlcNAcase	MESH:D013311	10724	Chemical	Gene	inhibition|compound|START_ENTITY mechanism|nmod|inhibition insight|nmod|mechanism insight|nmod|END_ENTITY	Structural insight into the mechanism of streptozotocin inhibition of O-GlcNAcase .
25683919	0	streptozotocin	121,135	PKC	84,87	streptozotocin	PKC	MESH:D013311	18753(Tax:10090)	Chemical	Gene	pathway|nmod|START_ENTITY pathway|compound|END_ENTITY	Non-receptor tyrosine kinase inhibitors enhances b-cell survival by suppressing the PKC signal transduction pathway in streptozotocin - induced b-cell apoptosis .
2946569	0	streptozotocin	56,70	Phenylethanolamine_N-methyltransferase	0,38	streptozotocin	Phenylethanolamine N-methyltransferase	MESH:D013311	24661(Tax:10116)	Chemical	Gene	rats|amod|START_ENTITY END_ENTITY|nmod|rats	Phenylethanolamine_N-methyltransferase in the brains of streptozotocin diabetic rats .
24055008	0	streptozotocin	76,90	TGF-b1	28,34	streptozotocin	TGF-b1	MESH:D013311	21803(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|role role|nmod|END_ENTITY	Protective role of low-dose TGF-b1 in early diabetic_nephropathy induced by streptozotocin .
12079841	0	streptozotocin	32,46	UCP-3	70,75	streptozotocin	UCP-3	MESH:D013311	22229(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|acl|overexpressing overexpressing|dobj|END_ENTITY	Enhanced diabetogenic effect of streptozotocin in mice overexpressing UCP-3 in skeletal muscle .
1533230	0	streptozotocin	55,69	apolipoprotein_B	17,33	streptozotocin	apolipoprotein B	MESH:D013311	54225(Tax:10116)	Chemical	Gene	rats|amod|START_ENTITY END_ENTITY|nmod|rats	Impaired hepatic apolipoprotein_B and E translation in streptozotocin diabetic rats .
9989930	0	streptozotocin	22,36	glucokinase	92,103	streptozotocin	glucokinase	MESH:D013311	103988(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Inhibitory effects of streptozotocin , tumor_necrosis_factor-alpha , and interleukin-1beta on glucokinase activity in pancreatic islets and gene expression of GLUT2 and glucokinase .
2482123	0	streptozotocin	75,89	growth_hormone	19,33	streptozotocin	growth hormone	MESH:D013311	81668(Tax:10116)	Chemical	Gene	rats|amod|START_ENTITY release|nmod|rats release|nmod|END_ENTITY	Altered release of growth_hormone from dispersed adenohypophysial cells of streptozotocin diabetic rats .
2575447	0	streptozotocin	75,89	growth_hormone	19,33	streptozotocin	growth hormone	MESH:D013311	81668(Tax:10116)	Chemical	Gene	rats|amod|START_ENTITY release|nmod|rats release|nmod|END_ENTITY	Altered release of growth_hormone from dispersed adenohypophysial cells of streptozotocin diabetic rats .
7835300	0	streptozotocin	11,25	growth_hormone	39,53	streptozotocin	growth hormone	MESH:D013311	14599(Tax:10090)	Chemical	Gene	treatment|compound|START_ENTITY treatment|nmod|END_ENTITY	Effects of streptozotocin treatment in growth_hormone -LRB- GH -RRB- and GH antagonist transgenic_mice .
8895392	0	streptozotocin	50,64	growth_hormone	2,16	streptozotocin	growth hormone	MESH:D013311	14599(Tax:10090)	Chemical	Gene	mice|nmod|START_ENTITY protects|dobj|mice protects|nsubj|antagonist antagonist|amod|END_ENTITY	A growth_hormone antagonist protects mice against streptozotocin induced glomerulosclerosis even in the presence of elevated levels of glucose and glycated hemoglobin .
7116620	0	streptozotocin	26,40	hemoglobin_A1	9,22	streptozotocin	hemoglobin A1	MESH:D013311	25632(Tax:10116)	Chemical	Gene	rats|amod|START_ENTITY END_ENTITY|nmod|rats	Elevated hemoglobin_A1 in streptozotocin diabetic rats and in rats on sucrose and galactose-enriched diets .
9604870	0	streptozotocin	96,110	insulin-like_growth_factor_binding_protein_1	48,92	streptozotocin	insulin-like growth factor binding protein 1	MESH:D013311	25685(Tax:10116)	Chemical	Gene	rats|amod|START_ENTITY END_ENTITY|nmod|rats	Octreotide prevents the early increase in renal insulin-like_growth_factor_binding_protein_1 in streptozotocin diabetic rats .
23761653	3	streptozotocin	576,590	mice	566,570	streptozotocin	apoE	MESH:D013311	11816(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nmod|END_ENTITY	Diabetes_mellitus was induced in 8-wk-old male apoE -LRB- - / - -RRB- mice with streptozotocin .
196920	0	streptozotocin	51,65	preproinsulin	13,26	streptozotocin	preproinsulin	MESH:D013311	3630	Chemical	Gene	Synthesis|nmod|START_ENTITY Synthesis|nmod|END_ENTITY	Synthesis of preproinsulin with RNA preparation of streptozotocin -- nicotinamide induced B-cell_tumor .
11839570	5	streptozotocin	771,785	rats	761,765	streptozotocin	VEGF	MESH:D013311	83785(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nmod|END_ENTITY	Diabetes was induced in Long-Evans rats with streptozotocin , resulting in a two - to threefold increase in retinal leukocyte adhesion .
9344881	0	stromelysin	29,40	Beta_2-microglobulin	0,20	stromelysin	Beta 2-microglobulin	null	567	Chemical	Gene	production|compound|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Beta_2-microglobulin induces stromelysin production by human synovial fibroblasts .
10336562	0	stromelysin	13,24	tumor_necrosis_factor_alpha	44,71	stromelysin	tumor necrosis factor alpha	null	280943(Tax:9913)	Chemical	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Induction of stromelysin gene expression by tumor_necrosis_factor_alpha is inhibited by dexamethasone , salicylate , and N-acetylcysteine in synovial fibroblasts .
18322691	0	strontium_ranelate	14,32	insulin_like_growth_factor-1	42,70	strontium ranelate	insulin like growth factor-1	MESH:C081587	3479	Chemical	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	The effect of strontium_ranelate on serum insulin_like_growth_factor-1 and leptin levels in osteoporotic post-menopausal women : a prospective study .
18926891	0	styrene	83,90	CC10	0,4	styrene	CC10	MESH:D020058	22287(Tax:10090)	Chemical	Gene	exposure|nmod|START_ENTITY mRNA|nmod|exposure mRNA|compound|END_ENTITY	CC10 mRNA and protein expression in Clara cells of CD-1 mice following exposure to styrene or its metabolites styrene_oxide or 4-vinylphenol .
19428955	0	styrene	28,35	CC10	59,63	styrene	CC10	MESH:D020058	22287(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of multiple doses of styrene and R-styrene_oxide on CC10 , bax , and bcl-2 expression in isolated Clara cells of CD-1 mice .
22807108	0	styrene	21,28	CYP2E1	0,6	styrene	CYP2E1	MESH:D020058	1571	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|nummod|END_ENTITY	CYP2E1 metabolism of styrene involves allostery .
15703451	0	styrene	55,62	cytochrome_P450	109,124	styrene	cytochrome P450	MESH:D020058	25251(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|enzymes enzymes|amod|END_ENTITY	Effects of pregnancy , age and sex in the metabolism of styrene in rat liver in relation to the regulation of cytochrome_P450 enzymes .
8070855	0	styrene	71,78	cytochrome_P450	30,45	styrene	cytochrome P450	MESH:D020058	4051	Chemical	Gene	metabolism|amod|START_ENTITY responsible|nmod|metabolism isozymes|xcomp|responsible isozymes|nsubj|Characterization Characterization|nmod|END_ENTITY	Characterization of the human cytochrome_P450 isozymes responsible for styrene metabolism .
7896422	0	styrene	60,67	monoamine_oxidase_B	9,28	styrene	monoamine oxidase B	MESH:D020058	4129	Chemical	Gene	exposed|xcomp|START_ENTITY exposed|nsubj|activity activity|compound|END_ENTITY	Platelet monoamine_oxidase_B activity in workers exposed to styrene .
9923754	0	styrene	10,17	monoamine_oxidase_B	21,40	styrene	monoamine oxidase B	MESH:D020058	25750(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	Effect of styrene on monoamine_oxidase_B activity in rat brain .
12208726	0	su5416	173,179	vascular_endothelial_growth_factor	119,153	su5416	vascular endothelial growth factor	MESH:C116890	7422	Chemical	Gene	START_ENTITY|amod|von_hippel-lindau_syndrome von_hippel-lindau_syndrome|nmod|therapy therapy|nmod|receptor receptor|compound|END_ENTITY	Rapid and durable recovery of visual function in a patient with von_hippel-lindau_syndrome after systemic therapy with vascular_endothelial_growth_factor receptor inhibitor su5416 .
23089527	0	suberoylanilide_hydroxamic_acid	63,94	histone_deacetylase	31,50	suberoylanilide hydroxamic acid	histone deacetylase	MESH:C111237	9734	Chemical	Gene	analogs|amod|START_ENTITY requirements|dep|analogs requirements|nmod|inhibitors inhibitors|amod|END_ENTITY	The structural requirements of histone_deacetylase inhibitors : suberoylanilide_hydroxamic_acid analogs modified at the C6 position .
23242251	0	suberoylanilide_hydroxamic_acid	107,138	histone_deacetylase	77,96	suberoylanilide hydroxamic acid	histone deacetylase	MESH:C111237	9734	Chemical	Gene	inhibitor|acl|START_ENTITY inhibitor|amod|END_ENTITY	Inhibition of lymphangiogenic factor VEGF-C expression and production by the histone_deacetylase inhibitor suberoylanilide_hydroxamic_acid in breast_cancer cells .
16288654	0	succinate	50,59	SDH	4,7	succinate	SDH	MESH:D019802	6390	Chemical	Gene	variants|amod|START_ENTITY resource|nmod|variants database|dep|resource database|compound|END_ENTITY	The SDH mutation database : an online resource for succinate dehydrogenase sequence variants involved in pheochromocytoma , paraganglioma and mitochondrial_complex_II_deficiency .
23764195	3	succinate	664,673	SDH	689,692	succinate	MDH	MESH:D019802	396894(Tax:9823)	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	We analysed the composition -LRB- % -RRB- of myosin_heavy-chain -LRB- MyHC -RRB- mRNA according to the absolute copies of each MyHC -LRB- I , IIa , IIb and IIx -RRB- mRNA , and the activities of succinate dehydrogenase -LRB- SDH -RRB- and malate_dehydrogenase -LRB- MDH -RRB- in the longissimus muscle .
18715869	0	succinate	80,89	SDH4	104,108	succinate	SDH4	MESH:D019802	851758(Tax:4932)	Chemical	Gene	mRNA|amod|START_ENTITY mRNA|compound|END_ENTITY	The Cth2 ARE-binding protein recruits the Dhh1 helicase to promote the decay of succinate dehydrogenase SDH4 mRNA in response to iron_deficiency .
8120006	0	succinate	111,120	SDH4	63,67	succinate	SDH4	MESH:D019802	851758(Tax:4932)	Chemical	Gene	dehydrogenase|amod|START_ENTITY subunit|nmod|dehydrogenase encoding|dobj|subunit Isolation|acl|encoding Isolation|nmod|gene gene|compound|END_ENTITY	Isolation and characterization of the Saccharomyces_cerevisiae SDH4 gene encoding a membrane anchor subunit of succinate dehydrogenase .
16361598	0	succinate	71,80	SDHA	96,100	succinate	SDHA	MESH:D019802	6389	Chemical	Gene	dehydrogenase|amod|START_ENTITY dehydrogenase|appos|END_ENTITY	Leigh_syndrome caused by mutations in the flavoprotein -LRB- Fp -RRB- subunit of succinate dehydrogenase -LRB- SDHA -RRB- .
23060355	0	succinate	53,62	SDHA	35,39	succinate	SDHA	MESH:D019802	6389	Chemical	Gene	gastrointestinal_stromal_tumors|amod|START_ENTITY identifies|nmod|gastrointestinal_stromal_tumors identifies|dobj|mutations mutations|compound|END_ENTITY	Loss of SDHA expression identifies SDHA mutations in succinate dehydrogenase-deficient gastrointestinal_stromal_tumors .
23060355	0	succinate	53,62	SDHA	8,12	succinate	SDHA	MESH:D019802	6389	Chemical	Gene	gastrointestinal_stromal_tumors|amod|START_ENTITY identifies|nmod|gastrointestinal_stromal_tumors identifies|nsubj|Loss Loss|nmod|expression expression|compound|END_ENTITY	Loss of SDHA expression identifies SDHA mutations in succinate dehydrogenase-deficient gastrointestinal_stromal_tumors .
19261994	0	succinate	30,39	SDHB	62,66	succinate	SDHB	MESH:D019802	6390	Chemical	Gene	dehydrogenase|amod|START_ENTITY gene|amod|dehydrogenase gene|appos|END_ENTITY	Novel mutation -LRB- L157X -RRB- in the succinate dehydrogenase B gene -LRB- SDHB -RRB- in a Japanese family with abdominal_paraganglioma following lung metastasis .
10216163	0	succinate	29,38	Sdh4p	69,74	succinate	Sdh4p	MESH:D019802	851758(Tax:4932)	Chemical	Gene	subunit|amod|START_ENTITY subunit|appos|END_ENTITY	The Saccharomyces_cerevisiae succinate dehydrogenase anchor subunit , Sdh4p : mutations at the C-terminal lys-132 perturb the hydrophobic domain .
17208193	0	succinate	81,90	Sdh4p	12,17	succinate	Sdh4p	MESH:D019802	851758(Tax:4932)	Chemical	Gene	dehydrogenase|compound|START_ENTITY role|nmod|dehydrogenase role|nmod|Tyr-89 Tyr-89|amod|END_ENTITY	The role of Sdh4p Tyr-89 in ubiquinone reduction by the Saccharomyces_cerevisiae succinate dehydrogenase .
9867924	0	succinate	20,29	bFGF	12,16	succinate	bFGF	MESH:D019802	54250(Tax:10116)	Chemical	Gene	level|amod|START_ENTITY END_ENTITY|nmod|level	-LSB- Effects of bFGF on succinate dehydrogenase level and oxygen consumption of skin_flap in rats -RSB- .
12172970	0	succinate	17,26	sdh4	52,56	succinate	sdh4	MESH:D019802	2948421(Tax:3197)	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Transcription of succinate dehydrogenase subunit 4 -LRB- sdh4 -RRB- gene in potato : detection of extensive RNA editing and co-transcription with cytochrome oxidase subunit III -LRB- cox3 -RRB- gene .
8581420	0	succinimide	47,58	leukocyte_elastase	120,138	succinimide	leukocyte elastase	MESH:C032620	1991	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|inhibitors inhibitors|nmod|END_ENTITY	Design , synthesis and biological evaluation of succinimide derivatives as potential mechanism-based inhibitors of human leukocyte_elastase , cathepsin_G_and_proteinase_3 .
9931257	0	succinyl-Ala-Ala-Pro-Phe-chloromethylketone	61,104	chymase	37,44	succinyl-Ala-Ala-Pro-Phe-chloromethylketone	chymase	MESH:C083541	1215	Chemical	Gene	complex|nmod|START_ENTITY END_ENTITY|nmod|complex	The 2.2 A crystal structure of human chymase in complex with succinyl-Ala-Ala-Pro-Phe-chloromethylketone : structural explanation for its dipeptidyl carboxypeptidase specificity .
1524874	0	succinylacetone	50,65	delta-Aminolevulinic_acid_dehydratase	0,37	succinylacetone	delta-Aminolevulinic acid dehydratase	MESH:C020804	25374(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|dep|effects	delta-Aminolevulinic_acid_dehydratase : effects of succinylacetone in rat liver and kidney in an in vivo model of the renal_Fanconi_syndrome .
2246808	0	succinylcholine	12,27	myoglobin	47,56	succinylcholine	myoglobin	MESH:D013390	4151	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|nmod|END_ENTITY	-LSB- Effects of succinylcholine on serum levels of myoglobin and CK in children under halothane or enflurane anesthesia -RSB- .
3661948	0	succinylcholine	82,97	myoglobin	41,50	succinylcholine	myoglobin	MESH:D013390	4151	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|compound|END_ENTITY	-LSB- Effect of selected anesthetics on serum myoglobin levels after administration of succinylcholine .
5915642	0	succinyldicholine	14,31	Pseudocholinesterase	35,55	succinyldicholine	Pseudocholinesterase	MESH:D013390	590	Chemical	Gene	Hydrolysis|nmod|START_ENTITY Hydrolysis|nmod|END_ENTITY	Hydrolysis of succinyldicholine by Pseudocholinesterase at low concentrations .
14611841	0	succinylhydroxamates	21,41	MMP-2	71,76	succinylhydroxamates	MMP-2	null	4313	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	MMPs inhibitors : new succinylhydroxamates with selective inhibition of MMP-2 over MMP-3 .
8026724	0	sucralfate	80,90	phospholipase_A2	27,43	sucralfate	phospholipase A2	MESH:D013392	151056	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of arachidonoyl phospholipase_A2 in prostaglandin-mediated action of sucralfate .
11135120	0	sucrose	42,49	AtSUC3	0,6	sucrose	AtSUC3	MESH:D013395	814817(Tax:3702)	Chemical	Gene	transporter|compound|START_ENTITY encoding|dobj|transporter gene|acl|encoding END_ENTITY|appos|gene	AtSUC3 , a gene encoding a new Arabidopsis sucrose transporter , is expressed in cells adjacent to the vascular tissue and in a carpel cell layer .
14739351	0	sucrose	42,49	AtSUC3	32,38	sucrose	AtSUC3	MESH:D013395	814817(Tax:3702)	Chemical	Gene	transporter|amod|START_ENTITY END_ENTITY|appos|transporter	Wounding enhances expression of AtSUC3 , a sucrose transporter from Arabidopsis sieve elements and sink tissues .
16146522	0	sucrose	11,18	AtSUC5	4,10	sucrose	AtSUC5	MESH:D013395	843520(Tax:3702)	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	The AtSUC5 sucrose transporter specifically expressed in the endosperm is involved in early seed development in Arabidopsis .
14609895	0	sucrose	53,60	Beta-endorphin	0,14	sucrose	Beta-endorphin	MESH:D013395	5443	Chemical	Gene	concentration|nmod|START_ENTITY concentration|amod|END_ENTITY	Beta-endorphin concentration after administration of sucrose in preterm infants .
9116697	0	sucrose	63,70	C-fos	0,5	sucrose	C-fos	MESH:D013395	314322(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	C-fos expression in the brainstem after voluntary ingestion of sucrose in the rat .
18454257	0	sucrose	139,146	CRP	104,107	sucrose	CRP	MESH:D013395	1401	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Natural honey and cardiovascular risk factors ; effects on blood_glucose , cholesterol , triacylglycerole , CRP , and body weight compared with sucrose .
8298534	0	sucrose	69,76	Cytochrome_P450	0,15	sucrose	Cytochrome P450	MESH:D013395	25251(Tax:10116)	Chemical	Gene	ingestion|compound|START_ENTITY END_ENTITY|nmod|ingestion	Cytochrome_P450 and glutathione in the liver of rats under exclusive sucrose ingestion .
18635449	0	sucrose	30,37	Fos	14,17	sucrose	Fos	MESH:D013395	314322(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of Fos during sham sucrose intake in rats with central gustatory lesions .
26068175	0	sucrose	98,105	Fos	65,68	sucrose	Fos	MESH:D013395	314322(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|enrichment enrichment|nmod|following following|compound|END_ENTITY	Effects of acute or chronic environmental enrichment on regional Fos protein expression following sucrose cue-reactivity testing in rats .
8578189	0	sucrose	70,77	Glucagon-like_peptide_1	0,23	sucrose	Glucagon-like peptide 1	MESH:D013395	2641	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|END_ENTITY	Glucagon-like_peptide_1 -LRB- 7-36 amide -RRB- secretion in response to luminal sucrose from the upper and lower gut .
12754265	0	sucrose	2,9	LjSUT4	23,29	sucrose	LjSUT4	MESH:D013395	553860(Tax:34305)	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	A sucrose transporter , LjSUT4 , is up-regulated during Lotus_japonicus nodule development .
18618272	0	sucrose	42,49	LjSUT4	23,29	sucrose	LjSUT4	MESH:D013395	553860(Tax:34305)	Chemical	Gene	START_ENTITY|nsubj|analysis analysis|nmod|END_ENTITY	Functional analysis of LjSUT4 , a vacuolar sucrose transporter from Lotus_japonicus .
25317812	0	sucrose	49,56	NASH	36,40	sucrose	NASH	MESH:D013395	170637(Tax:10116)	Chemical	Gene	impact|nmod|START_ENTITY impact|nmod|END_ENTITY	The impact of small doses of LPS on NASH in high sucrose and high fat diet induced rats .
21689173	0	sucrose	83,90	NOA1	59,63	sucrose	NOA1	MESH:D013395	823899(Tax:3702)	Chemical	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	Nitric_oxide accumulation in Arabidopsis is independent of NOA1 in the presence of sucrose .
10948254	0	sucrose	19,26	SUT4	41,45	sucrose	SUT4	MESH:D013395	102577516	Chemical	Gene	transporters|amod|START_ENTITY transporters|appos|END_ENTITY	A new subfamily of sucrose transporters , SUT4 , with low affinity/high capacity localized in enucleate sieve elements of plants .
10948254	5	sucrose	701,708	SUT4	627,631	sucrose	SUT4	MESH:D013395	102577516	Chemical	Gene	uptake|amod|START_ENTITY component|nmod|uptake corresponds|nmod|component corresponds|nummod|END_ENTITY	Thus , SUT4 corresponds to the low-affinity/high-capacity saturable component of sucrose uptake found in leaves .
22311778	0	sucrose	112,119	SUT4	32,36	sucrose	SUT4	MESH:D013395	837530(Tax:3702)	Chemical	Gene	regulate|nmod|START_ENTITY b5-2|xcomp|regulate b5-2|nsubj|interacts interacts|compound|END_ENTITY	Arabidopsis sucrose transporter SUT4 interacts with cytochrome b5-2 to regulate seed germination in response to sucrose and glucose .
22311778	0	sucrose	12,19	SUT4	32,36	sucrose	SUT4	MESH:D013395	837530(Tax:3702)	Chemical	Gene	START_ENTITY|xcomp|b5-2 b5-2|nsubj|interacts interacts|compound|END_ENTITY	Arabidopsis sucrose transporter SUT4 interacts with cytochrome b5-2 to regulate seed germination in response to sucrose and glucose .
21279648	0	sucrose	29,36	SlSUS4	47,53	sucrose	SlSUS4	MESH:D013395	101253025	Chemical	Gene	synthase|compound|START_ENTITY synthase|appos|END_ENTITY	Comparison of a novel tomato sucrose synthase , SlSUS4 , with previously described SlSUS isoforms reveals distinct sequence features and differential expression patterns in association with stem maturation .
17196771	0	sucrose	54,61	UDP-glucose	93,104	sucrose	UDP-glucose	MESH:D013395	7360	Chemical	Gene	genes|amod|START_ENTITY genes|nmod|END_ENTITY	Differential tissue/organ-dependent expression of two sucrose - and cold-responsive genes for UDP-glucose pyrophosphorylase in Populus .
11171080	4	sucrose	680,687	Ugp	698,701	sucrose	Ugp	MESH:D013395	821313(Tax:3702)	Chemical	Gene	effect|amod|START_ENTITY effect|nmod|END_ENTITY	The sucrose effect on Ugp was apparently specific and was mimicked by exposure of dark-adapted leaves to light .
21964712	0	sucrose	54,61	c-Fos	0,5	sucrose	c-Fos	MESH:D013395	314322(Tax:10116)	Chemical	Gene	intake|nmod|START_ENTITY brainstem|nmod|intake brainstem|nsubj|expression expression|amod|END_ENTITY	c-Fos expression in rat brainstem following intake of sucrose or saccharin .
8084508	0	sucrose	106,113	c-fos	10,15	sucrose	c-fos	MESH:D013395	314322(Tax:10116)	Chemical	Gene	expression|acl|START_ENTITY expression|amod|END_ENTITY	Increased c-fos expression in nucleus of the solitary tract correlated with conditioned taste aversion to sucrose in rats .
6281827	0	sucrose	19,26	cholecystokinin	37,52	sucrose	cholecystokinin	MESH:D013395	25298(Tax:10116)	Chemical	Gene	intake|amod|START_ENTITY intake|nmod|END_ENTITY	The suppression of sucrose intake by cholecystokinin is scaled according to the magnitude of the orosensory control over feeding .
6759077	0	sucrose	80,87	gastric_inhibitory_polypeptide	12,42	sucrose	gastric inhibitory polypeptide	MESH:D013395	2695	Chemical	Gene	role|acl|START_ENTITY role|nmod|END_ENTITY	The role of gastric_inhibitory_polypeptide in the augmented insulin response to sucrose .
25697639	0	sucrose	10,17	insulin	39,46	sucrose	insulin	MESH:D013395	3630	Chemical	Gene	consumption|amod|START_ENTITY consumption|nmod|END_ENTITY	Effect of sucrose consumption on serum insulin , serum cortisol and insulin sensitivity in migraine : Evidence of sex differences .
17190105	0	sucrose	8,15	lactase	36,43	sucrose	lactase	MESH:D013395	116569(Tax:10116)	Chemical	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Dietary sucrose enhances intestinal lactase gene expression in euthyroid rats .
6787180	0	sucrose	99,106	lactase	37,44	sucrose	lactase	MESH:D013395	116569(Tax:10116)	Chemical	Gene	starch|appos|START_ENTITY alpha-saccharides|dep|starch intake|nmod|alpha-saccharides due|nmod|intake END_ENTITY|xcomp|due	Increased activity of rat intestinal lactase due to increased intake of alpha-saccharides -LRB- starch , sucrose -RRB- in isocaloric diets .
12824809	0	sucrose	29,36	neuropeptide_Y	11,25	sucrose	neuropeptide Y	MESH:D013395	24604(Tax:10116)	Chemical	Gene	intake|compound|START_ENTITY END_ENTITY|nmod|intake	Effects of neuropeptide_Y on sucrose and ethanol intake and on anxiety-like behavior in high alcohol drinking -LRB- HAD -RRB- and low_alcohol_drinking -LRB- LAD -RRB- rats .
495028	0	sucrose	11,18	secretin	63,71	sucrose	secretin	MESH:D013395	24769(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	Intestinal sucrose assimilation in the rat after an Endogenous secretin release .
9404082	0	sucrose	36,43	sucrose_synthase	61,77	sucrose	sucrose synthase	MESH:D013395	106768289	Chemical	Gene	labeled|dobj|START_ENTITY labeled|nmod|END_ENTITY	Synthesis of asymmetrically labeled sucrose by a recombinant sucrose_synthase .
18540049	0	sucrose_octasulfate	23,42	FGF1	50,54	sucrose octasulfate	FGF1	MESH:C053081	25317(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Dimerization effect of sucrose_octasulfate on rat FGF1 .
21736375	0	sucrose_octasulfate	29,48	thrombin	15,23	sucrose octasulfate	thrombin	MESH:C053081	2147	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of thrombin with sucrose_octasulfate .
2891331	0	sufentanil	61,71	CO2	38,41	sufentanil	CO2	MESH:D017409	717	Chemical	Gene	response|nmod|START_ENTITY response|nmod|END_ENTITY	Analgesia and ventilatory response to CO2 following epidural sufentanil in children .
8110548	7	sufentanil	687,697	ml-1	731,735	sufentanil	ml-1	MESH:D017409	112744	Chemical	Gene	concentration|amod|START_ENTITY concentration|nmod|END_ENTITY	A sufentanil plasma concentration of 0.145 ng ml-1 -LRB- 95 % confidence limits 0.04 , 0.26 ng ml-1 -RRB- resulted in a 50 % reduction in the MAC of isoflurane .
5820643	1	sugar	104,109	C-3	93,96	sugar	C-3	null	718	Chemical	Gene	requirements|nmod|START_ENTITY requirements|nmod|END_ENTITY	Spatial and bonding requirements at C-3 of the sugar .
26972986	0	sugar	37,42	Cardiotrophin-1	0,15	sugar	Cardiotrophin-1	null	13019(Tax:10090)	Chemical	Gene	uptake|compound|START_ENTITY decreases|dobj|uptake decreases|nsubj|END_ENTITY	Cardiotrophin-1 decreases intestinal sugar uptake in mice and in Caco-2 cells .
9545564	0	sugar	92,97	ERD6	0,4	sugar	ERD6	null	837414(Tax:3702)	Chemical	Gene	transporter|compound|START_ENTITY encodes|dobj|transporter encodes|nsubj|END_ENTITY	ERD6 , a cDNA clone for an early dehydration-induced gene of Arabidopsis , encodes a putative sugar transporter .
12677461	0	sugar	40,45	Frt1	35,39	sugar	Frt1	null	854503(Tax:4932)	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	Functional characterization of the Frt1 sugar transporter and of fructose uptake in Kluyveromyces_lactis .
20201351	0	sugar	43,48	GLUT2	23,28	sugar	GLUT2	null	6514	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|nmod|transport	-LSB- The important role of GLUT2 in intestinal sugar transport and absorption -RSB- .
26003495	0	sugar	39,44	Ghrelin	0,7	sugar	Ghrelin	null	58991(Tax:10090)	Chemical	Gene	essential|nmod|START_ENTITY essential|nsubj|signaling signaling|compound|END_ENTITY	Ghrelin signaling is not essential for sugar or fat conditioned flavor preferences in mice .
9014361	0	sugar	16,21	Hexokinase	0,10	sugar	Hexokinase	null	851167(Tax:4932)	Chemical	Gene	sensor|compound|START_ENTITY END_ENTITY|nmod|sensor	Hexokinase as a sugar sensor in higher plants .
26535057	0	sugar	28,33	Hxt11	22,27	sugar	Hxt11	null	854009(Tax:4932)	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	An engineered cryptic Hxt11 sugar transporter facilitates glucose-xylose co-consumption in Saccharomyces_cerevisiae .
6250052	0	sugar	19,24	Insulin	0,7	sugar	Insulin	null	3630	Chemical	Gene	transport|compound|START_ENTITY stimulates|dobj|transport stimulates|nsubj|END_ENTITY	Insulin stimulates sugar transport in giant muscle fibres of the barnacle .
6308227	0	sugar	22,27	Insulin	0,7	sugar	Insulin	null	3630	Chemical	Gene	transport|compound|START_ENTITY regulation|nmod|transport regulation|compound|END_ENTITY	Insulin regulation of sugar transport in giant muscle fibres of the barnacle .
7534512	0	sugar	22,27	L-selectin	39,49	sugar	L-selectin	null	29259(Tax:10116)	Chemical	Gene	START_ENTITY|acl|ligand ligand|nmod|END_ENTITY	Sulfatide , a specific sugar ligand for L-selectin , blocks CCl4-induced liver_inflammation in rats .
22252010	0	sugar	17,22	Leptin	0,6	sugar	Leptin	null	3952	Chemical	Gene	transport|compound|START_ENTITY regulates|dobj|transport regulates|nsubj|END_ENTITY	Leptin regulates sugar and amino_acids transport in the human intestinal cell line Caco-2 .
12417639	0	sugar	34,39	Past-A	0,6	sugar	Past-A	null	50651	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|appos|transporter	Past-A , a novel proton-associated sugar transporter , regulates glucose homeostasis in the brain .
9274472	0	sugar	40,45	SGLT1	59,64	sugar	SGLT1	null	6523	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Nutrient regulation of human intestinal sugar transporter -LRB- SGLT1 -RRB- expression .
8274017	0	sugar	24,29	VIII	55,59	sugar	VIII	null	1351	Chemical	Gene	chains|compound|START_ENTITY chains|nmod|END_ENTITY	Structural study of the sugar chains of porcine factor VIII -- tissue - and species-specific glycosylation of factor VIII .
2113749	0	sugar	17,22	VIP	10,13	sugar	VIP	null	100352512(Tax:9986)	Chemical	Gene	transport|compound|START_ENTITY Effect|nmod|transport Effect|nmod|END_ENTITY	Effect of VIP on sugar transport in rabbit small intestine in vitro .
17169971	0	sugar	18,23	VIP36	44,49	sugar	VIP36	null	10960	Chemical	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Detection of weak sugar binding activity of VIP36 using VIP36-streptavidin complex and membrane-based sugar chains .
24790092	0	sugar	30,35	ZG16p	73,78	sugar	ZG16p	null	653808	Chemical	Gene	recognition|compound|START_ENTITY recognition|nmod|END_ENTITY	Structural basis for multiple sugar recognition of Jacalin-related human ZG16p lectin .
8390218	0	sugar	27,32	alpha_1-antitrypsin	49,68	sugar	alpha 1-antitrypsin	null	5265	Chemical	Gene	chains|compound|START_ENTITY chains|nmod|END_ENTITY	Structural analysis on the sugar chains of human alpha_1-antitrypsin : presence of fucosylated biantennary glycan in hepatocellular_carcinoma .
10572956	0	sugar	13,18	amyloid_precursor_protein	47,72	sugar	amyloid precursor protein	null	351	Chemical	Gene	chains|compound|START_ENTITY chains|nmod|END_ENTITY	Study of the sugar chains of recombinant human amyloid_precursor_protein produced by Chinese_hamster ovary cells .
22530344	0	sugar	115,120	apolipoprotein_A-I	46,64	sugar	apolipoprotein A-I	null	335	Chemical	Gene	promote|nmod|START_ENTITY promote|dobj|expression expression|amod|END_ENTITY	Grape seed proanthocyanidins extracts promote apolipoprotein_A-I mRNA expression in HepG2 cells under experimental sugar and high-sugar conditions .
468841	0	sugar	4,9	cold-insoluble_globulin	20,43	sugar	cold-insoluble globulin	null	2335	Chemical	Gene	chains|compound|START_ENTITY chains|nmod|END_ENTITY	The sugar chains of cold-insoluble_globulin .
25912189	0	sugar	19,24	collectin-K1	40,52	sugar	collectin-K1	null	78989	Chemical	Gene	recognition|compound|START_ENTITY recognition|nmod|END_ENTITY	Molecular basis of sugar recognition by collectin-K1 and the effects of mutations associated with 3MC syndrome .
25912189	0	sugar	19,24	collectin-K1	40,52	sugar	collectin-K1	null	78989	Chemical	Gene	recognition|compound|START_ENTITY recognition|nmod|END_ENTITY	Molecular basis of sugar recognition by collectin-K1 and the effects of mutations associated with 3MC syndrome .
1034634	0	sugar	15,20	epidermal_growth_factor	55,78	sugar	epidermal growth factor	null	1950	Chemical	Gene	Stimulation|nmod|START_ENTITY uptake|nsubj|Stimulation uptake|nmod|END_ENTITY	Stimulation of sugar uptake in cultured fibroblasts by epidermal_growth_factor -LRB- EGF -RRB- and EGF-binding arginine esterase .
10801876	0	sugar	19,24	epidermal_growth_factor_receptor	40,72	sugar	epidermal growth factor receptor	null	1956	Chemical	Gene	chain|compound|START_ENTITY chain|nmod|END_ENTITY	The Asn-420-linked sugar chain in human epidermal_growth_factor_receptor suppresses ligand-independent spontaneous oligomerization .
2813359	0	sugar	21,26	erythropoietin	88,102	sugar	erythropoietin	null	2056	Chemical	Gene	structure|compound|START_ENTITY structure|nmod|END_ENTITY	Relationship between sugar chain structure and biological activity of recombinant human erythropoietin produced in Chinese_hamster ovary cells .
16603548	0	sugar	42,47	galactokinase	73,86	sugar	galactokinase	null	852308(Tax:4932)	Chemical	Gene	specificity|compound|START_ENTITY specificity|nmod|END_ENTITY	Contribution of amino_acid side chains to sugar binding specificity in a galactokinase , Gal1p , and a transcriptional inducer , Gal3p .
15003531	0	sugar	144,149	gp120	160,165	sugar	gp120	null	3700	Chemical	Gene	chains|compound|START_ENTITY chains|nmod|END_ENTITY	Actinohivin , a novel anti-human_immunodeficiency_virus protein from an actinomycete , inhibits viral entry to cells by binding high-mannose type sugar chains of gp120 .
2455710	0	sugar	18,23	granulocyte-colony-stimulating_factor	52,89	sugar	granulocyte-colony-stimulating factor	null	1440	Chemical	Gene	chains|compound|START_ENTITY chains|nmod|END_ENTITY	Structures of the sugar chains of recombinant human granulocyte-colony-stimulating_factor produced by Chinese_hamster ovary cells .
1694845	0	sugar	9,14	granulocyte_colony-stimulating_factor	30,67	sugar	granulocyte colony-stimulating factor	null	1440	Chemical	Gene	chain|compound|START_ENTITY chain|nmod|END_ENTITY	O-linked sugar chain of human granulocyte_colony-stimulating_factor protects it against polymerization and denaturation allowing it to retain its biological activity .
10322544	0	sugar	23,28	hexokinase	3,13	sugar	hexokinase	null	851167(Tax:4932)	Chemical	Gene	sensor|compound|START_ENTITY sensor|nsubj|END_ENTITY	Is hexokinase really a sugar sensor in plants ?
736716	0	sugar	237,242	insulin	60,67	sugar	insulin	null	280829(Tax:9913)	Chemical	Gene	solutions|compound|START_ENTITY Behavior|nmod|solutions Behavior|nmod|constituents constituents|dep|fatty_acids fatty_acids|dep|END_ENTITY	-LSB- Behavior of various blood constituents -LRB- glucose , fructose , insulin , lactate , pyruvate , free fatty_acids , inorganic phosphate -RRB- and half-life of monosaccharides in the plasma after i.v. infusion of glucose , fructose , galactose and invert sugar solutions in ruminants .
736717	0	sugar	236,241	insulin	60,67	sugar	insulin	null	105613195	Chemical	Gene	solutions|compound|START_ENTITY infusion|nmod|solutions Behavior|nmod|infusion Behavior|nmod|constituents constituents|dep|fatty_acids fatty_acids|dep|END_ENTITY	-LSB- Behavior of various blood constituents -LRB- glucose , fructose , insulin , lactate , pyruvate , free fatty_acids , inorganic phosphate -RRB- and the half-life of monosaccharides in plasma after i.v infusion of glucose , fructose , galactose and invert sugar solutions in ruminants .
2503497	0	sugar	18,23	interferon-gamma	34,50	sugar	interferon-gamma	null	3458	Chemical	Gene	chains|compound|START_ENTITY chains|nmod|END_ENTITY	Structures of the sugar chains of interferon-gamma produced by human myelomonocyte cell line HBL-38 .
17488247	0	sugar	35,40	leptin	8,14	sugar	leptin	null	25608(Tax:10116)	Chemical	Gene	absorption|compound|START_ENTITY inhibits|dobj|absorption inhibits|nsubj|END_ENTITY	Luminal leptin inhibits intestinal sugar absorption in vivo .
1133566	0	sugar	23,28	prolactin	10,19	sugar	prolactin	null	24683(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY Effect|nmod|transport Effect|nmod|END_ENTITY	Effect of prolactin on sugar and amino_acid transport by the rat jejunum .
12198372	0	sugar	71,76	transferrin	86,97	sugar	transferrin	null	7018	Chemical	Gene	chain|compound|START_ENTITY chain|nmod|END_ENTITY	Acetaldehyde-induced growth_retardation and micro-heterogeneity of the sugar chain in transferrin synthesized by HepG2 cells .
24132392	0	sugarcane	44,53	transketolase	81,94	sugarcane	transketolase	null	100279513(Tax:4577)	Chemical	Gene	Cloning|nmod|START_ENTITY END_ENTITY|nsubj|Cloning	Cloning , expression and characterization of sugarcane -LRB- Saccharum officinarum L. -RRB- transketolase .
25497884	0	sugars	44,50	Trpm5	68,73	sugars	Trpm5	MESH:D002241	56843(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Flavor preference conditioning by different sugars in sweet ageusic Trpm5 knockout mice .
6209184	0	sugars	43,49	dopamine-beta-hydroxylase	60,85	sugars	dopamine-beta-hydroxylase	MESH:D002241	25699(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	Effect of diabetic_hyperglycemia and other sugars on plasma dopamine-beta-hydroxylase activity .
8896999	0	sugars	39,45	elastin	16,23	sugars	elastin	MESH:D002241	2006	Chemical	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of elastin and aorta with sugars in vitro and their effects on biochemical and physical properties .
11846406	0	sulfakinin	71,81	DSK-R1	91,97	sulfakinin	DSK-R1	null	32864(Tax:7227)	Chemical	Gene	receptor|compound|START_ENTITY expression|nmod|receptor END_ENTITY|nsubj|expression	Cloning and functional expression of the first Drosophila_melanogaster sulfakinin receptor DSK-R1 .
20481572	0	sulfamates	12,22	carbonic_anhydrase_II	41,62	sulfamates	carbonic anhydrase II	null	760	Chemical	Gene	START_ENTITY|nmod|isoform isoform|amod|END_ENTITY	Affinity of sulfamates and sulfamides to carbonic_anhydrase_II isoform : experimental and molecular modeling approaches .
24289143	0	sulfamide	89,98	carbonic_anhydrase_II	119,140	sulfamide	carbonic anhydrase II	CHEBI:29368	760	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|nmod|END_ENTITY	QM/MM calculations reveal the different nature of the interaction of two carborane-based sulfamide inhibitors of human carbonic_anhydrase_II .
23849171	0	sulfamides	56,66	carbonic_anhydrase_IX	10,31	sulfamides	carbonic anhydrase IX	CHEBI:51871	768	Chemical	Gene	Targeting|nmod|START_ENTITY Targeting|dobj|END_ENTITY	Targeting carbonic_anhydrase_IX by nitroimidazole based sulfamides enhances the therapeutic effect of tumor irradiation : a new concept of dual targeting drugs .
25596758	0	sulfamoyl_acetamides	92,112	COX-2	142,147	sulfamoyl acetamides	COX-2	null	5743	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Synthesis , biological evaluation and docking analysis of a new series of methylsulfonyl and sulfamoyl_acetamides and ethyl_acetates as potent COX-2 inhibitors .
17450321	0	sulfane_sulfur	35,49	N-acetyl-L-cysteine	0,19	sulfane sulfur	N-acetyl-L-cysteine	null	7504	Chemical	Gene	source|nmod|START_ENTITY END_ENTITY|nmod|source	N-acetyl-L-cysteine as a source of sulfane_sulfur in astrocytoma and astrocyte cultures : correlations with cell proliferation .
11372587	0	sulfaphenazole	95,109	CYP2C9	26,32	sulfaphenazole	CYP2C9	MESH:D013426	1559	Chemical	Gene	inhibition|acl|START_ENTITY contributions|dep|inhibition contributions|nmod|END_ENTITY	Relative contributions of CYP2C9 and 2C19 to phenytoin 4-hydroxylation in vitro : inhibition by sulfaphenazole , omeprazole , and ticlopidine .
19252303	0	sulfasalazine	28,41	ATP-binding_cassette_G2	61,84	sulfasalazine	ATP-binding cassette G2	MESH:D012460	9429	Chemical	Gene	transport|amod|START_ENTITY characterization|nmod|transport characterization|nmod|END_ENTITY	Kinetic characterization of sulfasalazine transport by human ATP-binding_cassette_G2 .
11472325	0	sulfasalazine	50,63	MAdCAM-1	96,104	sulfasalazine	MAdCAM-1	MESH:D012460	8174	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Glucocorticoids and IL-10 , but not 6-MP , 5-ASA or sulfasalazine block endothelial expression of MAdCAM-1 : implications for inflammatory_bowel_disease therapy .
11642327	0	sulfasalazine	47,60	N-Acetyltransferase_2	0,21	sulfasalazine	N-Acetyltransferase 2	MESH:D012460	10	Chemical	Gene	correlates|nmod|START_ENTITY correlates|amod|END_ENTITY	N-Acetyltransferase_2 genotype correlates with sulfasalazine pharmacokinetics after multiple dosing in healthy Japanese subjects .
12934082	2	sulfasalazine	504,517	death	482,487	sulfasalazine	CD95L	MESH:D012460	356	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|END_ENTITY	We here report that CD95L-induced cell death is inhibited by sulfasalazine -LRB- SS -RRB- in all of four human glioma cell lines , both in the absence and presence of cycloheximide -LRB- CHX -RRB- .
11014343	0	sulfasalazine	26,39	tumor_necrosis_factor_alpha	49,76	sulfasalazine	tumor necrosis factor alpha	MESH:D012460	21926(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	The antiinflammatory drug sulfasalazine inhibits tumor_necrosis_factor_alpha expression in macrophages by inducing apoptosis .
24491019	0	sulfate	76,83	Apolipoprotein_E	0,16	sulfate	Apolipoprotein E	CHEBI:16189	100773810	Chemical	Gene	increases|nmod|START_ENTITY increases|nsubj|END_ENTITY	Apolipoprotein_E increases cell association of amyloid-b 40 through heparan sulfate and LRP1 dependent pathways .
20548024	0	sulfate	48,55	C1q	14,17	sulfate	C1q	CHEBI:16189	712	Chemical	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Cutting edge : C1q binds deoxyribose and heparan sulfate through neighboring sites of its recognition domain .
8671676	0	sulfate	98,105	CD72	67,71	sulfate	CD72	CHEBI:16189	12517(Tax:10090)	Chemical	Gene	signaling|nmod|START_ENTITY signaling|nmod|END_ENTITY	Antigen receptor-mediated B cell death is blocked by signaling via CD72 or treatment with dextran sulfate and is defective in autoimmunity-prone mice .
8975717	0	sulfate	50,57	DSPG3	26,31	sulfate	DSPG3	CHEBI:16189	1833	Chemical	Gene	START_ENTITY|nsubj|Characterization Characterization|nmod|END_ENTITY	Characterization of human DSPG3 , a small dermatan sulfate proteoglycan .
11241838	0	sulfate	39,46	DTDST	60,65	sulfate	DTDST	CHEBI:16189	1836	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mutations in the diastrophic_dysplasia sulfate transporter -LRB- DTDST -RRB- gene -LRB- SLC26A2 -RRB- : 22 novel mutations , mutation review , associated skeletal phenotypes , and diagnostic relevance .
18056413	1	sulfate	139,146	DTDST	160,165	sulfate	DTDST	CHEBI:16189	1836	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Diastrophic_dysplasia sulfate transporter -LRB- DTDST -RRB- is a sulfate/chloride antiporter whose function is impaired in several human chondrodysplasias .
18708426	0	sulfate	24,31	DTDST	58,63	sulfate	DTDST	CHEBI:16189	1836	Chemical	Gene	SLC26A2|amod|START_ENTITY SLC26A2|appos|END_ENTITY	A novel mutation in the sulfate transporter gene SLC26A2 -LRB- DTDST -RRB- specific to the Finnish population causes de la Chapelle_dysplasia .
15693006	0	sulfate	88,95	EMR2	59,63	sulfate	EMR2	CHEBI:16189	30817	Chemical	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification of the epidermal growth factor-TM7 receptor EMR2 and its ligand dermatan sulfate in rheumatoid synovial tissue .
10516434	0	sulfate	80,87	HIP	109,112	sulfate	HIP	CHEBI:16189	6159	Chemical	Gene	protein|amod|START_ENTITY genes|compound|protein genes|appos|END_ENTITY	The pig aminoacylase_1 -LRB- ACY1 -RRB- and ribosomal_protein_L29 -LRB- RPL29 -RRB- / heparin/heparan sulfate interacting protein -LRB- HIP -RRB- genes are located together at 13q21 -- > q22 , corresponding to human 3p21 .1 .
8662617	0	sulfate	56,63	HIP	27,30	sulfate	HIP	CHEBI:16189	6159	Chemical	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Cell surface expression of HIP , a novel heparin/heparan sulfate binding protein , of human uterine epithelial cells and cell lines .
9546743	0	sulfate	56,63	HIP	28,31	sulfate	HIP	CHEBI:16189	6159	Chemical	Gene	protein|compound|START_ENTITY expression|appos|protein expression|nmod|END_ENTITY	Complementary expression of HIP , a cell-surface heparan sulfate binding protein , and perlecan at the human fetal-maternal interface .
1901275	0	sulfate	34,41	Interferon-gamma	0,16	sulfate	Interferon-gamma	CHEBI:16189	3458	Chemical	Gene	START_ENTITY|nsubj|binds binds|amod|END_ENTITY	Interferon-gamma binds to heparan sulfate by a cluster of amino_acids located in the C-terminal part of the molecule .
8674529	0	sulfate	55,62	Interferon-gamma	0,16	sulfate	Interferon-gamma	CHEBI:16189	3458	Chemical	Gene	incorporation|nmod|START_ENTITY inhibits|dobj|incorporation inhibits|nsubj|END_ENTITY	Interferon-gamma inhibits 35S incorporation in heparan sulfate synthesized by human skin fibroblasts .
1997196	0	sulfate	129,136	Interleukin_2	0,13	sulfate	Interleukin 2	CHEBI:16189	100302458(Tax:9986)	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Interleukin_2 induced leukocyte adhesion to the normal and tumor microvascular endothelium in vivo and its inhibition by dextran sulfate : implications for vascular_leak_syndrome .
12590599	0	sulfate	28,35	NDST-1	84,90	sulfate	NDST-1	CHEBI:16189	3340	Chemical	Gene	START_ENTITY|nmod|mutations mutations|nmod|END_ENTITY	Distinct effects on heparan sulfate structure by different active site mutations in NDST-1 .
15319440	0	sulfate	8,15	NDST1	71,76	sulfate	NDST1	CHEBI:16189	15531(Tax:10090)	Chemical	Gene	START_ENTITY|acl|synthesized synthesized|nmod|deficient deficient|nmod|END_ENTITY	Heparan sulfate synthesized by mouse embryonic stem cells deficient in NDST1 and NDST2 is 6-O-sulfated but contains no N-sulfate groups .
18337501	0	sulfate	8,15	NDST1	58,63	sulfate	NDST1	CHEBI:16189	3340	Chemical	Gene	biosynthesis|nsubj|START_ENTITY biosynthesis|ccomp|affect affect|dobj|expression expression|compound|END_ENTITY	Heparan sulfate biosynthesis enzymes EXT1 and EXT2 affect NDST1 expression and heparan sulfate sulfation .
20154712	0	sulfate	17,24	NF-kappaB	59,68	sulfate	NF-kappaB	CHEBI:16189	4790	Chemical	Gene	START_ENTITY|advcl|inhibiting inhibiting|dobj|activation activation|amod|END_ENTITY	Oligomannurarate sulfate blocks_tumor growth by inhibiting NF-kappaB activation .
21111708	0	sulfate	16,23	NaS1	11,15	sulfate	NaS1	CHEBI:16189	6561	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	WITHDRAWN : NaS1 sulfate transporter is linked to hyposulfatemia and longevity .
21298488	0	sulfate	33,40	NaS1	54,58	sulfate	NaS1	CHEBI:16189	6561	Chemical	Gene	roles|nmod|START_ENTITY transporters|nsubj|roles transporters|dobj|END_ENTITY	Physiological roles of mammalian sulfate transporters NaS1 and Sat1 .
16020517	0	sulfate	69,76	Ndst1	77,82	sulfate	Ndst1	CHEBI:16189	15531(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|function function|amod|END_ENTITY	Cerebral_hypoplasia and craniofacial_defects in mice lacking heparan sulfate Ndst1 gene function .
17107998	0	sulfate	8,15	Ndst1	34,39	sulfate	Ndst1	CHEBI:16189	3340	Chemical	Gene	START_ENTITY|ccomp|required required|nsubjpass|END_ENTITY	Heparan sulfate biosynthetic gene Ndst1 is required for FGF signaling in early lens development .
20502530	0	sulfate	20,27	Ndst1	46,51	sulfate	Ndst1	CHEBI:16189	15531(Tax:10090)	Chemical	Gene	sulfotransferase|compound|START_ENTITY sulfotransferase|appos|END_ENTITY	Loss of the heparan sulfate sulfotransferase , Ndst1 , in mammary epithelial cells selectively blocks lobuloalveolar development in mice .
2138364	0	sulfate	23,30	PF4	102,105	sulfate	PF4	CHEBI:16189	5196	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	The effect of dermatan sulfate on in vitro human plasma_coagulation , platelet_aggregation and beta_TG / PF4 release .
18255326	0	sulfate	10,17	Rv1739c	82,89	sulfate	Rv1739c	CHEBI:16189	887208(Tax:83332)	Chemical	Gene	uptake|nsubj|START_ENTITY uptake|advcl|overexpressing overexpressing|dobj|END_ENTITY	Increased sulfate uptake by E. _ coli overexpressing the SLC26-related SulP protein Rv1739c from Mycobacterium_tuberculosis .
19636956	0	sulfate	81,88	Rv1739c	61,68	sulfate	Rv1739c	CHEBI:16189	887208(Tax:83332)	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|appos|transporter	NMR assignment and secondary structure of the STAS domain of Rv1739c , a putative sulfate transporter of Mycobacterium_tuberculosis .
23453247	0	sulfate	16,23	SLC13A4	93,100	sulfate	SLC13A4	CHEBI:16189	26266	Chemical	Gene	mRNA|amod|START_ENTITY identifies|nsubj|mRNA identifies|dobj|END_ENTITY	Human placental sulfate transporter mRNA profiling from term pregnancies identifies abundant SLC13A4 in syncytiotrophoblasts and SLC26A2 in cytotrophoblasts .
23485456	0	sulfate	40,47	SLC13A4	32,39	sulfate	SLC13A4	CHEBI:16189	26266	Chemical	Gene	START_ENTITY|nsubj|analysis analysis|nmod|END_ENTITY	Molecular analysis of the human SLC13A4 sulfate transporter gene promoter .
11241838	0	sulfate	39,46	SLC26A2	73,80	sulfate	SLC26A2	CHEBI:16189	1836	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mutations in the diastrophic_dysplasia sulfate transporter -LRB- DTDST -RRB- gene -LRB- SLC26A2 -RRB- : 22 novel mutations , mutation review , associated skeletal phenotypes , and diagnostic relevance .
11457925	0	sulfate	31,38	SLC26A2	0,7	sulfate	SLC26A2	CHEBI:16189	1836	Chemical	Gene	transporter|amod|START_ENTITY END_ENTITY|appos|transporter	SLC26A2 -LRB- diastrophic_dysplasia sulfate transporter -RRB- is expressed in developing and mature cartilage but also in other tissues and cell types .
24591336	0	sulfate	22,29	SLC26A2	43,50	sulfate	SLC26A2	CHEBI:16189	13521(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Diastrophic_dysplasia sulfate transporter -LRB- SLC26A2 -RRB- is expressed in the adrenal cortex and regulates aldosterone secretion .
14597181	0	sulfate	66,73	SLC26a2	86,93	sulfate	SLC26a2	CHEBI:16189	513953(Tax:9913)	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Molecular cloning , mapping , and functional analysis of the bovine sulfate transporter SLC26a2 gene .
10535998	0	sulfate	54,61	SUT-1	45,50	sulfate	SUT-1	CHEBI:16189	26266	Chemical	Gene	transporter|amod|START_ENTITY END_ENTITY|appos|transporter	Molecular cloning and functional analysis of SUT-1 , a sulfate transporter from human high endothelial venules .
15802556	0	sulfate	29,36	Slc13a1	9,16	sulfate	Slc13a1	CHEBI:16189	6561	Chemical	Gene	START_ENTITY|nsubj|Roles Roles|nmod|END_ENTITY	Roles of Slc13a1 and Slc26a1 sulfate transporters of eel kidney in sulfate homeostasis and osmoregulation in freshwater .
17038798	0	sulfate	56,63	Slc13a4	84,91	sulfate	Slc13a4	CHEBI:16189	243755(Tax:10090)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular cloning and characterization of the mouse Na + sulfate cotransporter gene -LRB- Slc13a4 -RRB- : Structure and expression .
19666466	0	sulfate	84,91	Sulf1	40,45	sulfate	Sulf2	CHEBI:16189	55959	Chemical	Gene	START_ENTITY|nsubj|Characterization Characterization|nmod|END_ENTITY	Characterization of the human sulfatase Sulf1 and its high affinity heparin/heparan sulfate interaction domain .
22298771	0	sulfate	45,52	Sulf1	91,96	sulfate	Sulf1	CHEBI:16189	240725(Tax:10090)	Chemical	Gene	patterns|nmod|START_ENTITY sulfatases|nsubj|patterns sulfatases|dobj|END_ENTITY	Organ-specific sulfation patterns of heparan sulfate generated by extracellular sulfatases Sulf1 and Sulf2 in mice .
23074159	0	sulfate	76,83	Sulf1	32,37	sulfate	Sulf1	CHEBI:16189	23213	Chemical	Gene	sulfation|compound|START_ENTITY regulate|dobj|sulfation regulate|nsubj|patterns patterns|nmod|END_ENTITY	Distinct expression patterns of Sulf1 and Hs6st1 spatially regulate heparan sulfate sulfation during prostate development .
23300081	0	sulfate	19,26	Sulf1	45,50	sulfate	Sulf1	CHEBI:16189	53437(Tax:7227)	Chemical	Gene	START_ENTITY|ccomp|wingless wingless|nsubj|facilitates facilitates|amod|END_ENTITY	Drosophila heparan sulfate 6-O-endosulfatase Sulf1 facilitates wingless -LRB- Wg -RRB- protein degradation .
19280636	0	sulfate	140,147	TGF-beta_3	102,112	sulfate	TGF-beta 3	CHEBI:16189	7043	Chemical	Gene	complexed|nmod|START_ENTITY END_ENTITY|acl|complexed	Chondrogenic differentiation of mesenchymal stem cells embedded in a scaffold by long-term release of TGF-beta_3 complexed with chondroitin sulfate .
22760779	0	sulfate	8,15	TLR4	31,35	sulfate	TLR4	CHEBI:16189	7099	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	Heparan sulfate , an endogenous TLR4 agonist , promotes acute_GVHD after allogeneic stem cell transplantation .
3158721	0	sulfate	126,133	acetylcholinesterase	36,56	sulfate	acetylcholinesterase	CHEBI:16189	83817(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|distribution distribution|nmod|END_ENTITY	Atypical distribution of asymmetric acetylcholinesterase in mutant PC12 pheochromocytoma cells lacking a cell surface heparan sulfate proteoglycan .
15026992	0	sulfate	56,63	alphaV_integrin	29,44	sulfate	alphaV integrin	CHEBI:16189	100008956(Tax:9986)	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Adenovirus vectors targeting alphaV_integrin or heparan sulfate receptors display different distribution of transgene activity after intramuscular injection .
7833476	0	sulfate	87,94	antithrombin	53,65	sulfate	antithrombin	CHEBI:16189	462	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Fibrinogen inhibits the heparin cofactor II-mediated antithrombin activity of dermatan sulfate .
11500500	0	sulfate	30,37	apolipoprotein_E	71,87	sulfate	apolipoprotein E	CHEBI:16189	348	Chemical	Gene	START_ENTITY|dobj|activity activity|nmod|END_ENTITY	New insights into the heparan sulfate proteoglycan-binding activity of apolipoprotein_E .
22371501	5	sulfate	666,673	bFGF	634,638	sulfate	bFGF	CHEBI:16189	14173(Tax:10090)	Chemical	Gene	binding|nmod|START_ENTITY END_ENTITY|amod|binding	Moreover , GSPP competitively inhibited bFGF binding to heparin/heparan sulfate via direct binding to bFGF .
14585835	0	sulfate	62,69	endostatin	20,30	sulfate	endostatin	CHEBI:16189	80781	Chemical	Gene	binding|nmod|START_ENTITY END_ENTITY|amod|binding	Characterization of endostatin binding to heparin and heparan sulfate by surface plasmon resonance and molecular modeling : role of divalent cations .
2458767	0	sulfate	18,25	extracellular-superoxide_dismutase	60,94	sulfate	extracellular-superoxide dismutase	CHEBI:16189	780439(Tax:9823)	Chemical	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	Heparin - , dextran sulfate - and protamine-induced release of extracellular-superoxide_dismutase to plasma in pigs .
14441863	0	sulfate	39,46	fibrinogen	15,25	sulfate	fibrinogen	CHEBI:16189	2244	Chemical	Gene	START_ENTITY|nsubj|Interaction Interaction|nmod|END_ENTITY	Interaction of fibrinogen with dextran sulfate .
12626395	0	sulfate	88,95	glial_cell_line-derived_neurotrophic_factor	21,64	sulfate	glial cell line-derived neurotrophic factor	CHEBI:16189	2668	Chemical	Gene	The|nmod|START_ENTITY The|nmod|END_ENTITY	The binding of human glial_cell_line-derived_neurotrophic_factor to heparin and heparan sulfate : importance of 2-O-sulfate groups and effect on its interaction with its receptor , GFRalpha1 .
15760902	0	sulfate	55,62	heparanase	102,112	sulfate	heparanase	CHEBI:16189	10855	Chemical	Gene	START_ENTITY|dobj|domains domains|nmod|END_ENTITY	Identification and characterization of heparin/heparan sulfate binding domains of the endoglycosidase heparanase .
19115257	0	sulfate	21,28	heparanase	41,51	sulfate	heparanase	CHEBI:16189	10855	Chemical	Gene	START_ENTITY|acl|released released|nmod|END_ENTITY	Cell surface heparan sulfate released by heparanase promotes melanoma cell migration and angiogenesis .
6687888	0	sulfate	46,53	heparin_cofactor_II	14,33	sulfate	heparin cofactor II	CHEBI:16189	3053	Chemical	Gene	START_ENTITY|nsubj|Activation Activation|nmod|END_ENTITY	Activation of heparin_cofactor_II by dermatan sulfate .
8157651	0	sulfate	53,60	hepatocyte_growth_factor	15,39	sulfate	hepatocyte growth factor	CHEBI:16189	3082	Chemical	Gene	START_ENTITY|nsubj|Interaction Interaction|nmod|END_ENTITY	Interaction of hepatocyte_growth_factor with heparan sulfate .
14629481	0	sulfate	34,41	high_molecular_weight_kininogen	45,76	sulfate	high molecular weight kininogen	CHEBI:16189	3827	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Assessment of the role of heparan sulfate in high_molecular_weight_kininogen binding to human umbilical vein endothelial cells .
8665399	0	sulfate	42,49	interleukin-1_beta	11,29	sulfate	interleukin-1 beta	CHEBI:16189	24494(Tax:10116)	Chemical	Gene	suppresses|compound|START_ENTITY suppresses|amod|END_ENTITY	Release of interleukin-1_beta by dermatan sulfate suppresses hepatocyte growth .
9417813	0	sulfate	83,90	interleukin_2	38,51	sulfate	interleukin 2	CHEBI:16189	3558	Chemical	Gene	START_ENTITY|nsubj|Characterization Characterization|nmod|END_ENTITY	Characterization of human recombinant interleukin_2 binding to heparin and heparan sulfate using an ELISA approach .
12658800	0	sulfate	66,73	platelet_factor_4	11,28	sulfate	platelet factor 4	CHEBI:16189	56744(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of platelet_factor_4 on expression of bone marrow heparan sulfate in syngenic bone marrow transplantation mice .
1727651	0	sulfate	40,47	proteoglycan	48,60	sulfate	proteoglycan	CHEBI:16189	395565(Tax:9031)	Chemical	Gene	START_ENTITY|dobj|protein protein|amod|END_ENTITY	Identification of chick corneal keratan sulfate proteoglycan precursor protein in whole corneas and in cultured corneal fibroblasts .
15070814	0	sulfate	30,37	sat-1	56,61	sulfate	sat-1	CHEBI:16189	480865(Tax:9615)	Chemical	Gene	transporter|amod|START_ENTITY END_ENTITY|nsubj|transporter	A_dileucine motif targets the sulfate anion transporter sat-1 to the basolateral membrane in renal cell lines .
6393023	0	sulfate	57,64	somatomedin	15,26	sulfate	somatomedin	CHEBI:16189	24482(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|activity activity|compound|END_ENTITY	Reduced plasma somatomedin activity and costal cartilage sulfate incorporation activity during experimental growth_retardation in the fetal rat .
19783663	0	sulfate	125,132	syndecan	170,178	sulfate	syndecan	CHEBI:16189	6382	Chemical	Gene	specificity|compound|START_ENTITY specificity|nmod|END_ENTITY	ScFv antibody-induced translocation of cell-surface heparan_sulfate_proteoglycan to endocytic vesicles : evidence for heparan sulfate epitope specificity and role of both syndecan and glypican .
2452495	0	sulfate	26,33	thrombin	53,61	sulfate	thrombin	CHEBI:16189	2147	Chemical	Gene	START_ENTITY|nmod|inactivation inactivation|nmod|END_ENTITY	Trigger action of dextran sulfate on inactivation of thrombin .
16412266	0	sulfate_berberine	19,36	TNF-alpha	66,75	sulfate berberine	TNF-alpha	null	24835(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	Effects of neutral sulfate_berberine on LPS-induced cardiomyocyte TNF-alpha secretion , abnormal calcium cycling , and cardiac_dysfunction in rats .
26350456	0	sulfate_sodium	86,100	Na-H_exchanger_isoform-2	0,24	sulfate sodium	Na-H exchanger isoform-2	null	24783(Tax:10116)	Chemical	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Na-H_exchanger_isoform-2 -LRB- NHE2 -RRB- mediates butyrate-dependent Na + absorption in dextran sulfate_sodium -LRB- DSS -RRB- - induced colitis .
12860483	0	sulfate_sodium	69,83	group_IIA_phospholipase_A2	8,34	sulfate sodium	group IIA phospholipase A2	null	29692(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Role Role|nmod|END_ENTITY	Role of group_IIA_phospholipase_A2 in rat colitis induced by dextran sulfate_sodium .
12702049	0	sulfate_sodium	52,66	tumor_necrosis_factor-alpha	70,97	sulfate sodium	tumor necrosis factor-alpha	null	21926(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Enhanced intestinal inflammation induced by dextran sulfate_sodium in tumor_necrosis_factor-alpha deficient mice .
11465426	0	sulfathiazole	21,34	CO2	52,55	sulfathiazole	CO2	MESH:C005312	717	Chemical	Gene	control|nmod|START_ENTITY control|nmod|END_ENTITY	Polymorph control of sulfathiazole in supercritical CO2 .
17853408	0	sulfatide	47,56	CXCR4	27,32	sulfatide	CXCR4	CHEBI:18318	7852	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Up-regulation of leukocyte CXCR4 expression by sulfatide : an L-selectin-dependent pathway on CD4 + T cells .
15173196	0	sulfatide	25,34	annexin_V	6,15	sulfatide	annexin V	CHEBI:18318	308	Chemical	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	Human annexin_V binds to sulfatide : contribution to regulation of blood_coagulation .
6343536	0	sulfatides	45,55	Hageman_factor	14,28	sulfatides	Hageman factor	MESH:D013433	2161	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of Hageman_factor -LRB- factor XII -RRB- by sulfatides and other agents in the absence of plasma proteases .
6604770	0	sulfatides	122,132	Hageman_factor	91,105	sulfatides	Hageman factor	MESH:D013433	2161	Chemical	Gene	role|nmod|START_ENTITY role|nmod|prekallikrein prekallikrein|nmod|activation activation|nmod|END_ENTITY	The role of prekallikrein and high-molecular-weight_kininogen in the contact activation of Hageman_factor -LRB- factor XII -RRB- by sulfatides and other agents .
7096358	0	sulfhydryl	10,20	5-oxo-L-prolinase	61,78	sulfhydryl	5-oxo-L-prolinase	null	116684(Tax:10116)	Chemical	Gene	modification|amod|START_ENTITY Effect|nmod|modification Effect|nmod|END_ENTITY	Effect of sulfhydryl group modification on the activities of 5-oxo-L-prolinase .
1378110	0	sulfhydryl	177,187	ACE	218,221	sulfhydryl	ACE	null	1636	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Antioxidant effects of angiotensin-converting enzyme -LRB- ACE -RRB- inhibitors : free radical and oxidant scavenging are sulfhydryl dependent , but lipid peroxidation is inhibited by both sulfhydryl - and nonsulfhydryl-containing ACE inhibitors .
15916753	0	sulfhydryl	18,28	ALR	37,40	sulfhydryl	ALR	null	27100(Tax:10116)	Chemical	Gene	Expression|nmod|START_ENTITY oxidase|nsubj|Expression oxidase|dobj|END_ENTITY	Expression of the sulfhydryl oxidase ALR -LRB- Augmenter of Liver_Regeneration -RRB- in adult rat brain .
21421053	0	sulfhydryl	117,127	Erv1p	111,116	sulfhydryl	Erv1p	null	2671	Chemical	Gene	oxidase|amod|START_ENTITY oxidase|amod|END_ENTITY	Improved quantitative and qualitative production of single-domain intrabodies mediated by the co-expression of Erv1p sulfhydryl oxidase .
15770657	0	sulfhydryl	19,29	QSOX	38,42	sulfhydryl	QSOX	null	84491(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Ontogenesis of the sulfhydryl oxidase QSOX expression in rat brain .
17331072	0	sulfhydryl	65,75	QSOX1	85,90	sulfhydryl	QSOX1	null	5768	Chemical	Gene	oxidase|amod|START_ENTITY oxidase|appos|END_ENTITY	Intracellular catalysis of disulfide bond formation by the human sulfhydryl oxidase , QSOX1 .
3401446	0	sulfhydryl	23,33	S100b	61,66	sulfhydryl	S100b	null	525716(Tax:9913)	Chemical	Gene	reactivity|amod|START_ENTITY reactivity|nmod|END_ENTITY	Reinvestigation of the sulfhydryl reactivity in bovine brain S100b -LRB- beta beta -RRB- protein and the microtubule-associated tau proteins .
6248117	2	sulfhydryl	472,482	S18	500,503	sulfhydryl	S21	null	6227	Chemical	Gene	group|amod|START_ENTITY group|nmod|END_ENTITY	Changes in the electron paramagnetic resonance spectra or in the polarization of fluorescence of labeled ribosomes reveal that streptomycin alters the mobility of labels bound to the sulfhydryl group of protein S18 while neomycin affects the mobility of labels bound to the sulfhydryl groups of proteins S1 , S21 and/or L10 .
19033012	0	sulfhydryl	25,35	angiotensin-converting_enzyme	36,65	sulfhydryl	angiotensin-converting enzyme	null	1636	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|amod|END_ENTITY	Long-term treatment with sulfhydryl angiotensin-converting_enzyme inhibition reduces carotid intima-media thickening and improves the nitric_oxide / oxidative stress pathways in newly diagnosed patients with mild to moderate primary hypertension .
3372519	0	sulfhydryl	31,41	heart_aconitase	96,111	sulfhydryl	heart aconitase	null	396999(Tax:9823)	Chemical	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of the reactive sulfhydryl and sequences of cysteinyl-tryptic peptides from beef heart_aconitase .
6769491	0	sulfhydryl	30,40	lipoxygenase-1	59,73	sulfhydryl	lipoxygenase-1	null	547923(Tax:3847)	Chemical	Gene	groups|amod|START_ENTITY effect|nmod|groups effect|nmod|END_ENTITY	The effect of modification of sulfhydryl groups in soybean lipoxygenase-1 .
6447696	0	sulfhydryls	23,34	myosin	42,48	sulfhydryls	myosin	null	79784	Chemical	Gene	START_ENTITY|nmod|ATPase ATPase|compound|END_ENTITY	Studies on the role of sulfhydryls in the myosin ATPase .
7147215	0	sulfinpyrazone	10,24	antithrombin_III	30,46	sulfinpyrazone	antithrombin III	MESH:D013442	462	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of sulfinpyrazone upon antithrombin_III and platelet_factor_4 in chronic_renal_failure .
19086807	0	sulfiredoxin	13,25	peroxiredoxin_III	78,95	sulfiredoxin	peroxiredoxin III	null	11757(Tax:10090)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of sulfiredoxin via an Nrf2-dependent pathway and hyperoxidation of peroxiredoxin_III in the lungs of mice exposed to hyperoxia .
2796592	0	sulfobromophthalein	79,98	ornithine_decarboxylase	13,36	sulfobromophthalein	ornithine decarboxylase	MESH:D013448	24609(Tax:10116)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of ornithine_decarboxylase and S-adenosylmethionine_decarboxylase by sulfobromophthalein in rats .
7544008	0	sulfoglucuronosyl_paragloboside	50,81	L-selectin	96,106	sulfoglucuronosyl paragloboside	L-selectin	MESH:C051917	6402	Chemical	Gene	START_ENTITY|appos|ligand ligand|nmod|END_ENTITY	Interleukin_1_beta up-regulates the expression of sulfoglucuronosyl_paragloboside , a ligand for L-selectin , in brain microvascular endothelial cells .
19533738	0	sulfoglucuronosyl_paragloboside	79,110	nuclear_factor_kappaB	126,147	sulfoglucuronosyl paragloboside	nuclear factor kappaB	MESH:C051917	4790	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Sulfoglucuronosyl_paragloboside is a ligand for T cell adhesion : regulation of sulfoglucuronosyl_paragloboside expression via nuclear_factor_kappaB signaling .
817929	0	sulfoiduronate	14,28	sulfatase	29,38	sulfoiduronate	sulfatase	null	347527	Chemical	Gene	deficiency|amod|START_ENTITY deficiency|compound|END_ENTITY	Mosaicism for sulfoiduronate sulfatase deficiency in carriers of Hunter 's _ syndrome .
10557279	0	sulfolipid	79,89	SQD1	21,25	sulfolipid	SQD1	CHEBI:61384	829440(Tax:3702)	Chemical	Gene	START_ENTITY|nsubj|structure structure|nmod|END_ENTITY	Crystal structure of SQD1 , an enzyme involved in the biosynthesis of the plant sulfolipid headgroup donor UDP-sulfoquinovose .
12354881	0	sulfolipid_I	80,92	IgA	63,66	sulfolipid I	IgA	MESH:C009355	973	Chemical	Gene	response|nmod|START_ENTITY response|appos|END_ENTITY	Serodiagnosis of tuberculosis : comparison of immunoglobulin_A -LRB- IgA -RRB- response to sulfolipid_I with IgG and IgM responses to 2,3-diacyltrehalose , 2,3,6-triacyltrehalose , and cord factor antigens .
12354881	0	sulfolipid_I	80,92	immunoglobulin_A	45,61	sulfolipid I	immunoglobulin A	MESH:C009355	973	Chemical	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Serodiagnosis of tuberculosis : comparison of immunoglobulin_A -LRB- IgA -RRB- response to sulfolipid_I with IgG and IgM responses to 2,3-diacyltrehalose , 2,3,6-triacyltrehalose , and cord factor antigens .
16168644	0	sulfonamidate_dipeptides	28,52	aminopeptidase_N	97,113	sulfonamidate dipeptides	aminopeptidase N	null	5850654(Tax:562)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Phosphinate , sulfonate , and sulfonamidate_dipeptides as potential inhibitors of Escherichia_coli aminopeptidase_N .
21353784	0	sulfonamide	15,26	AKT	27,30	sulfonamide	AKT	CHEBI:35358	207	Chemical	Gene	domain|amod|START_ENTITY domain|compound|END_ENTITY	Development of sulfonamide AKT PH domain inhibitors .
24566147	0	sulfonamide	40,51	DNA_methyltransferases	65,87	sulfonamide	DNA methyltransferases	CHEBI:35358	1786	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|nmod|END_ENTITY	Rationalization of activity cliffs of a sulfonamide inhibitor of DNA_methyltransferases with induced-fit docking .
11934587	0	sulfonamide_hydroxamate	13,36	TACE	37,41	sulfonamide hydroxamate	TACE	null	6868	Chemical	Gene	START_ENTITY|dobj|inhibitors inhibitors|amod|END_ENTITY	Anthranilate sulfonamide_hydroxamate TACE inhibitors .
11934588	0	sulfonamide_hydroxamate	13,36	TACE	37,41	sulfonamide hydroxamate	TACE	null	6868	Chemical	Gene	START_ENTITY|dobj|inhibitors inhibitors|amod|END_ENTITY	Anthranilate sulfonamide_hydroxamate TACE inhibitors .
16046123	0	sulfonamides	56,68	PTP1B	79,84	sulfonamides	PTP1B	MESH:D013449	5770	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Discovery and structure-activity relationships of novel sulfonamides as potent PTP1B inhibitors .
24251446	0	sulfonamides	26,38	lipoamide_dehydrogenase	73,96	sulfonamides	lipoamide dehydrogenase	MESH:D013449	1738	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|END_ENTITY	Lipoamide channel-binding sulfonamides selectively inhibit mycobacterial lipoamide_dehydrogenase .
16358064	0	sulfonates	117,127	dimethylarginine_dimethylaminohydrolase	14,53	sulfonates	dimethylarginine dimethylaminohydrolase	CHEBI:33543	23576	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of dimethylarginine_dimethylaminohydrolase -LRB- DDAH -RRB- and arginine deiminase -LRB- ADI -RRB- by pentafluorophenyl -LRB- PFP -RRB- sulfonates .
9825305	0	sulfones	42,50	cyclooxygenase-2	20,36	sulfones	cyclooxygenase-2	MESH:D013450	5743	Chemical	Gene	inhibitors|dep|START_ENTITY inhibitors|nmod|END_ENTITY	Novel inhibitors of cyclooxygenase-2 : the sulfones and sulfonamides of 1,2-diaryl-4 ,5 - difluorobenzene .
8230103	0	sulfonium	29,38	dopamine_D2_receptor	89,109	sulfonium	dopamine D2 receptor	CHEBI:30488	13489(Tax:10090)	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	The interaction of ammonium , sulfonium , and sulfide analogues of metoclopramide with the dopamine_D2_receptor .
9134746	0	sulfonoquinovosyl_dipalmitoyl_glyceride	41,80	P-selectin	84,94	sulfonoquinovosyl dipalmitoyl glyceride	P-selectin	null	6403	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Isolation and structure determination of sulfonoquinovosyl_dipalmitoyl_glyceride , a P-selectin receptor inhibitor from the alga Dictyochloris fragrans .
17516295	0	sulfonylurea	39,51	ABCC8	67,72	sulfonylurea	ABCC8	CHEBI:26831	6833	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The common C49620T polymorphism in the sulfonylurea receptor gene -LRB- ABCC8 -RRB- , pancreatic beta cell function and long-term diabetic_complications in obese patients with long-lasting type_2_diabetes_mellitus .
22306677	0	sulfonylurea	48,60	ABCC8	132,137	sulfonylurea	ABCC8	CHEBI:26831	6833	Chemical	Gene	switching|nmod|START_ENTITY medicine|acl|switching dictated|nsubj|medicine dictated|nmod|mutation mutation|compound|END_ENTITY	Personalized medicine switching from insulin to sulfonylurea in permanent neonatal_diabetes_mellitus dictated by a novel activating ABCC8 mutation .
22533711	0	sulfonylurea	90,102	ABCC8	0,5	sulfonylurea	ABCC8	CHEBI:26831	6833	Chemical	Gene	therapy|compound|START_ENTITY associated|nmod|therapy associated|nsubjpass|polymorphisms polymorphisms|compound|END_ENTITY	ABCC8 polymorphisms are associated with triglyceride concentration in type 2 diabetics on sulfonylurea therapy .
22842804	0	sulfonylurea	11,23	ABCC8	130,135	sulfonylurea	ABCC8	CHEBI:26831	6833	Chemical	Gene	treatment|compound|START_ENTITY treatment|nmod|gene gene|compound|END_ENTITY	Successful sulfonylurea treatment of a neonate with neonatal diabetes_mellitus due to a novel missense mutation , p.P1199L , in the ABCC8 gene .
14684837	0	sulfonylurea	11,23	AtMRP5	27,33	sulfonylurea	AtMRP5	CHEBI:26831	839277(Tax:3702)	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of sulfonylurea by AtMRP5 , an Arabidopsis multidrug resistance-related protein that functions in salt tolerance .
22260657	0	sulfonylurea	9,21	Epac2	0,5	sulfonylurea	Epac2	CHEBI:26831	11069	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|dep|receptor	Epac2 : a sulfonylurea receptor ?
10459863	0	sulfonylurea	62,74	GLUT2	0,5	sulfonylurea	GLUT2	CHEBI:26831	6514	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	GLUT2 and glucokinase expression is coordinately regulated by sulfonylurea .
15240182	0	sulfonylurea	62,74	INS-1	45,50	sulfonylurea	INS-1	CHEBI:26831	2305	Chemical	Gene	cells|nmod|START_ENTITY cells|compound|END_ENTITY	Synergistic effect on insulin secretion from INS-1 cells of a sulfonylurea and a phosphodiesterase 3 inhibitor .
1828656	0	sulfonylurea	15,27	Insulin	0,7	sulfonylurea	Insulin	CHEBI:26831	3630	Chemical	Gene	agent|compound|START_ENTITY END_ENTITY|nmod|agent	Insulin plus a sulfonylurea agent for treating type 2 diabetes .
6392057	0	sulfonylurea	45,57	Insulin	0,7	sulfonylurea	Insulin	CHEBI:26831	3630	Chemical	Gene	effect|nmod|START_ENTITY cells|dep|effect cells|amod|END_ENTITY	Insulin binding on MOLT 4 cells : effect of a sulfonylurea .
6401923	0	sulfonylurea	72,84	Insulin	0,7	sulfonylurea	Insulin	CHEBI:26831	3630	Chemical	Gene	agents|compound|START_ENTITY impact|nmod|agents resistance|dep|impact resistance|compound|END_ENTITY	Insulin resistance in noninsulin-dependent_diabetes_mellitus : impact of sulfonylurea agents in vivo and in vitro .
10742701	0	sulfonylurea	26,38	atrial_natriuretic_peptide	42,68	sulfonylurea	atrial natriuretic peptide	CHEBI:26831	608289(Tax:9615)	Chemical	Gene	START_ENTITY|nmod|release release|amod|END_ENTITY	The modulating actions of sulfonylurea on atrial_natriuretic_peptide release in experimental acute heart_failure .
11289470	0	sulfonylurea	96,108	glucokinase	119,130	sulfonylurea	glucokinase	CHEBI:26831	2645	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Role of common sequence variants in insulin secretion in familial type 2 diabetic kindreds : the sulfonylurea receptor , glucokinase , and hepatocyte nuclear factor 1alpha genes .
24503189	0	sulfonylurea	123,135	glucokinase	37,48	sulfonylurea	glucokinase	CHEBI:26831	2645	Chemical	Gene	responsive|nmod|START_ENTITY hyperglycaemia|amod|responsive conferring|dobj|hyperglycaemia gene|acl|conferring gene|amod|END_ENTITY	A novel heterozygous mutation in the glucokinase gene conferring exercise-induced symptomatic hyperglycaemia responsive to sulfonylurea .
10878751	0	sulfonylurea	6,18	insulin	74,81	sulfonylurea	insulin	CHEBI:26831	3630	Chemical	Gene	drugs|compound|START_ENTITY Novel|dobj|drugs Novel|xcomp|promote promote|dobj|secretion secretion|nmod|END_ENTITY	Novel sulfonylurea and non-sulfonylurea drugs to promote the secretion of insulin .
11151028	0	sulfonylurea	103,115	insulin	23,30	sulfonylurea	insulin	CHEBI:26831	3630	Chemical	Gene	failure|amod|START_ENTITY patients|nmod|failure efficient|nmod|patients efficient|nsubj|END_ENTITY	Gliclazide and bedtime insulin are more efficient than insulin alone for type 2 diabetic patients with sulfonylurea secondary failure .
11151028	0	sulfonylurea	103,115	insulin	55,62	sulfonylurea	insulin	CHEBI:26831	3630	Chemical	Gene	failure|amod|START_ENTITY patients|nmod|failure efficient|nmod|patients efficient|nmod|END_ENTITY	Gliclazide and bedtime insulin are more efficient than insulin alone for type 2 diabetic patients with sulfonylurea secondary failure .
11272143	0	sulfonylurea	86,98	insulin	17,24	sulfonylurea	insulin	CHEBI:26831	3630	Chemical	Gene	due|nmod|START_ENTITY mutations|amod|due children|nmod|mutations secretion|nmod|children secretion|nsubj|Dysregulation Dysregulation|nmod|END_ENTITY	Dysregulation of insulin secretion in children with congenital_hyperinsulinism due to sulfonylurea receptor mutations .
11473038	0	sulfonylurea	41,53	insulin	87,94	sulfonylurea	insulin	CHEBI:26831	3630	Chemical	Gene	administration|nmod|START_ENTITY increases|nsubj|administration increases|dobj|secretion secretion|compound|END_ENTITY	Acute and short-term administration of a sulfonylurea -LRB- gliclazide -RRB- increases pulsatile insulin secretion in type 2 diabetes .
1468283	0	sulfonylurea	121,133	insulin	100,107	sulfonylurea	insulin	CHEBI:26831	3630	Chemical	Gene	START_ENTITY|nsubj|responses responses|compound|END_ENTITY	Chronic sulfonylurea therapy augments basal and meal-stimulated insulin secretion while attenuating insulin responses to sulfonylurea per se .
1468283	0	sulfonylurea	121,133	insulin	64,71	sulfonylurea	insulin	CHEBI:26831	3630	Chemical	Gene	augments|advcl|START_ENTITY augments|dobj|secretion secretion|compound|END_ENTITY	Chronic sulfonylurea therapy augments basal and meal-stimulated insulin secretion while attenuating insulin responses to sulfonylurea per se .
1468283	0	sulfonylurea	8,20	insulin	100,107	sulfonylurea	insulin	CHEBI:26831	3630	Chemical	Gene	therapy|compound|START_ENTITY augments|nsubj|therapy augments|advcl|sulfonylurea sulfonylurea|nsubj|responses responses|compound|END_ENTITY	Chronic sulfonylurea therapy augments basal and meal-stimulated insulin secretion while attenuating insulin responses to sulfonylurea per se .
1468283	0	sulfonylurea	8,20	insulin	64,71	sulfonylurea	insulin	CHEBI:26831	3630	Chemical	Gene	therapy|compound|START_ENTITY augments|nsubj|therapy augments|dobj|secretion secretion|compound|END_ENTITY	Chronic sulfonylurea therapy augments basal and meal-stimulated insulin secretion while attenuating insulin responses to sulfonylurea per se .
16505505	0	sulfonylurea	101,113	insulin	35,42	sulfonylurea	insulin	CHEBI:26831	3630	Chemical	Gene	therapy|nmod|START_ENTITY added|nmod|therapy glargine|acl|added glargine|compound|END_ENTITY	Triple therapy in type 2 diabetes : insulin glargine or rosiglitazone added to combination therapy of sulfonylurea plus metformin in insulin-naive patients .
16732009	0	sulfonylurea	213,225	insulin	102,109	sulfonylurea	insulin	CHEBI:26831	3630	Chemical	Gene	controlled|nmod|START_ENTITY controlled|nsubj|study study|acl|compare compare|dobj|profile profile|nmod|END_ENTITY	An open , randomized , parallel-group study to compare the efficacy and safety profile of inhaled human insulin -LRB- Exubera -RRB- with metformin as adjunctive therapy in patients with type 2 diabetes poorly controlled on a sulfonylurea .
1752344	0	sulfonylurea	30,42	insulin	79,86	sulfonylurea	insulin	CHEBI:26831	3630	Chemical	Gene	Restoration|nmod|START_ENTITY Restoration|nmod|control control|nmod|END_ENTITY	Restoration of sensitivity to sulfonylurea after strict glycaemic control with insulin in non-obese type 2 diabetic subjects .
20350924	0	sulfonylurea	89,101	insulin	31,38	sulfonylurea	insulin	CHEBI:26831	3630	Chemical	Gene	glargine|nmod|START_ENTITY glargine|nsubj|control control|nmod|END_ENTITY	Improved glycemic control with insulin glargine versus pioglitazone as add-on therapy to sulfonylurea or metformin in patients with uncontrolled type_2_diabetes_mellitus .
21153274	0	sulfonylurea	19,31	insulin	43,50	sulfonylurea	insulin	CHEBI:26831	3630	Chemical	Gene	control|compound|START_ENTITY mechanisms|nmod|control mechanisms|nmod|secretion secretion|compound|END_ENTITY	New mechanisms for sulfonylurea control of insulin secretion .
21481127	0	sulfonylurea	73,85	insulin	21,28	sulfonylurea	insulin	CHEBI:26831	3630	Chemical	Gene	metformin|nmod|START_ENTITY added|xcomp|metformin glargine|acl|added glargine|compound|END_ENTITY	An analysis of early insulin glargine added to metformin with or without sulfonylurea : impact on glycaemic control and hypoglycaemia .
21923847	0	sulfonylurea	86,98	insulin	72,79	sulfonylurea	insulin	CHEBI:26831	3630	Chemical	Gene	failure|compound|START_ENTITY achieving|nmod|failure achieving|nmod|END_ENTITY	Predictive characteristics of patients achieving glycaemic control with insulin after sulfonylurea failure .
23149657	0	sulfonylurea	41,53	insulin	80,87	sulfonylurea	insulin	CHEBI:26831	3630	Chemical	Gene	diabetes|nmod|START_ENTITY duration|nmod|diabetes have|nsubj|duration have|dobj|association association|nmod|cessation cessation|compound|END_ENTITY	Short duration of diabetes and disuse of sulfonylurea have any association with insulin cessation of the patients with type 2 diabetes in a clinical setting in Japan -LRB- JDDM 30 -RRB- .
24113668	0	sulfonylurea	100,112	insulin	41,48	sulfonylurea	insulin	CHEBI:26831	3630	Chemical	Gene	metformin|nmod|START_ENTITY Exenatide|advcl|metformin Exenatide|dobj|weekly weekly|nmod|END_ENTITY	Exenatide once weekly versus daily basal insulin as add-on treatment to metformin with or without a sulfonylurea : a retrospective pooled analysis in patients with poor glycemic control .
25299054	0	sulfonylurea	65,77	insulin	104,111	sulfonylurea	insulin	CHEBI:26831	3630	Chemical	Gene	combination|compound|START_ENTITY vitamin_B12_deficiency|nmod|combination prevalence|nmod|vitamin_B12_deficiency compared|nsubj|prevalence compared|nmod|combination combination|compound|END_ENTITY	Higher prevalence of metformin-induced vitamin_B12_deficiency in sulfonylurea combination compared with insulin combination in patients with type 2 diabetes : a cross-sectional study .
3934860	0	sulfonylurea	90,102	insulin	26,33	sulfonylurea	insulin	CHEBI:26831	3630	Chemical	Gene	glibenclamide|compound|START_ENTITY treatment|nmod|glibenclamide treatment|nmod|diabetics diabetics|amod|dependent dependent|advmod|END_ENTITY	-LSB- Combination treatment of insulin dependent elderly diabetics -LRB- type_II_diabetes -RRB- with the sulfonylurea compound glibenclamide -RSB- .
478080	0	sulfonylurea	21,33	insulin	52,59	sulfonylurea	insulin	CHEBI:26831	3630	Chemical	Gene	therapy|compound|START_ENTITY Effects|nmod|therapy Effects|nmod|END_ENTITY	Effects of long term sulfonylurea therapy on plasma insulin and fasting lipid levels .
6376033	0	sulfonylurea	14,26	insulin	77,84	sulfonylurea	insulin	CHEBI:26831	3630	Chemical	Gene	treatment|compound|START_ENTITY impact|nmod|treatment impact|amod|responsible responsible|nmod|resistance resistance|compound|END_ENTITY	The impact of sulfonylurea treatment upon the mechanisms responsible for the insulin resistance in type_II_diabetes .
6434794	0	sulfonylurea	9,21	insulin	42,49	sulfonylurea	insulin	CHEBI:26831	3630	Chemical	Gene	Trial|nmod|START_ENTITY Trial|nmod|END_ENTITY	Trial of sulfonylurea in combination with insulin in the therapy of diabetes_type_I and II .
6759246	0	sulfonylurea	10,22	insulin	44,51	sulfonylurea	insulin	CHEBI:26831	3630	Chemical	Gene	treatment|compound|START_ENTITY Effect|nmod|treatment Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of sulfonylurea treatment on in vivo insulin secretion and action in patients with non-insulin-dependent_diabetes_mellitus .
6772676	0	sulfonylurea	28,40	insulin	70,77	sulfonylurea	insulin	CHEBI:26831	3630	Chemical	Gene	START_ENTITY|acl|increase increase|dobj|receptors receptors|compound|END_ENTITY	Direct in vitro effect of a sulfonylurea to increase human fibroblast insulin receptors .
6800910	0	sulfonylurea	77,89	insulin	28,35	sulfonylurea	insulin	CHEBI:26831	3630	Chemical	Gene	treatments|nmod|START_ENTITY Comparison|nmod|treatments Comparison|nmod|levels levels|compound|END_ENTITY	Comparison of diurnal serum insulin levels during short term treatments with sulfonylurea and with insulin in non-insulin_dependent_diabetes .
7716547	0	sulfonylurea	39,51	insulin	77,84	sulfonylurea	insulin	CHEBI:26831	3630	Chemical	Gene	receptor|compound|START_ENTITY Cloning|nmod|receptor Cloning|dep|regulator regulator|nmod|secretion secretion|compound|END_ENTITY	Cloning of the beta cell high-affinity sulfonylurea receptor : a regulator of insulin secretion .
8922367	0	sulfonylurea	14,26	insulin	44,51	sulfonylurea	insulin	CHEBI:26831	483665(Tax:9615)	Chemical	Gene	stimulation|nmod:poss|START_ENTITY stimulation|nmod|secretion secretion|compound|END_ENTITY	Mechanisms of sulfonylurea 's stimulation of insulin secretion in vivo : selective amplification of insulin secretory burst mass .
8922367	0	sulfonylurea	14,26	insulin	98,105	sulfonylurea	insulin	CHEBI:26831	483665(Tax:9615)	Chemical	Gene	stimulation|nmod:poss|START_ENTITY Mechanisms|nmod|stimulation Mechanisms|dep|amplification amplification|nmod|mass mass|compound|END_ENTITY	Mechanisms of sulfonylurea 's stimulation of insulin secretion in vivo : selective amplification of insulin secretory burst mass .
9026680	0	sulfonylurea	158,170	insulin	51,58	sulfonylurea	insulin	CHEBI:26831	3630	Chemical	Gene	combined|nmod|START_ENTITY combined|nsubj|study study|nmod|efficiency efficiency|nmod|END_ENTITY	-LSB- Comparative study of the efficiency of ultralente insulin and NPH insulin combined with sulfonylurea in type 2 diabetes patients with secondary tolerance to sulfonylurea .
9026680	0	sulfonylurea	89,101	insulin	51,58	sulfonylurea	insulin	CHEBI:26831	3630	Chemical	Gene	combined|nmod|START_ENTITY combined|nsubj|study study|nmod|efficiency efficiency|nmod|END_ENTITY	-LSB- Comparative study of the efficiency of ultralente insulin and NPH insulin combined with sulfonylurea in type 2 diabetes patients with secondary tolerance to sulfonylurea .
903405	0	sulfonylurea	85,97	insulin	16,23	sulfonylurea	insulin	CHEBI:26831	3630	Chemical	Gene	drugs|compound|START_ENTITY action|nmod|drugs mechanism|nmod|action Potentiation|dep|mechanism Potentiation|nmod|action action|compound|END_ENTITY	Potentiation of insulin action : a probable mechanism for the anti-diabetic action of sulfonylurea drugs .
9505163	0	sulfonylurea	84,96	insulin	10,17	sulfonylurea	insulin	CHEBI:26831	3630	Chemical	Gene	failure|compound|START_ENTITY patients|nmod|failure distribution|nmod|patients therapy|nmod|distribution therapy|compound|END_ENTITY	Effect of insulin therapy on body fat distribution in NIDDM patients with secondary sulfonylurea failure : a preliminary report .
9627359	0	sulfonylurea	25,37	insulin	10,17	sulfonylurea	insulin	CHEBI:26831	3630	Chemical	Gene	therapy|compound|START_ENTITY Effect|nmod|therapy Effect|nmod|END_ENTITY	Effect of insulin versus sulfonylurea therapy on cardiovascular risk factors and fibrinolysis in type_II_diabetes .
2559864	0	sulfonylurea	24,36	skeletal_muscle_glycogen_synthase	40,73	sulfonylurea	skeletal muscle glycogen synthase	CHEBI:26831	2997	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Postreceptor effects of sulfonylurea on skeletal_muscle_glycogen_synthase activity in type II diabetic patients .
19696956	0	sulfonylurea_glibenclamide	91,117	alpha-ENaC	63,73	sulfonylurea glibenclamide	alpha-ENaC	null	25122(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of the C-terminal part of the extracellular domain of the alpha-ENaC in activation by sulfonylurea_glibenclamide .
7750476	0	sulfonylurea_glimepiride	121,145	GLUT4	89,94	sulfonylurea glimepiride	GLUT4	null	25139(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Direct stimulation of myocardial glucose transport and glucose_transporter-1 -LRB- GLUT1 -RRB- and GLUT4 protein expression by the sulfonylurea_glimepiride .
24464600	0	sulfonylureas	98,111	CYP2C9	0,6	sulfonylureas	CYP2C9	null	1559	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|END_ENTITY	CYP2C9 * 2 allele increases risk for hypoglycemia in POR * 1 / * 1 type 2 diabetic patients treated with sulfonylureas .
26446475	0	sulfonylureas	20,33	HNF1A	37,42	sulfonylureas	HNF1A	D013453	6927	Chemical	Gene	START_ENTITY|nmod|patients patients|compound|END_ENTITY	Recent Half-life of sulfonylureas in HNF1A and HNF4A human MODY patients is not prolonged as suggested by the mouse Hnf1a - / - model .
21349175	0	sulfonylureas	35,48	TCF7L2	0,6	sulfonylureas	TCF7L2	null	6934	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	TCF7L2 and therapeutic response to sulfonylureas in patients with type_2_diabetes .
2125014	0	sulfonylureas	113,126	insulin	51,58	sulfonylureas	insulin	null	3630	Chemical	Gene	therapy|nmod|START_ENTITY therapy|nmod|END_ENTITY	Combined therapy with glibenclamide and ultralente insulin in lean patients with NIDDM with secondary failure of sulfonylureas .
7047169	0	sulfonylureas	13,26	insulin	68,75	sulfonylureas	insulin	null	3630	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|secretion secretion|nmod|END_ENTITY	Influence of sulfonylureas on the secretion , disposal and effect of insulin .
11249129	0	sulfoquinovosylacylglycerols	13,41	DNA_polymerase_alpha	68,88	sulfoquinovosylacylglycerols	DNA polymerase alpha	null	5422	Chemical	Gene	Synthesis|nmod|START_ENTITY Synthesis|nmod|END_ENTITY	Synthesis of sulfoquinovosylacylglycerols , inhibitors of eukaryotic DNA_polymerase_alpha and beta .
23159064	0	sulforaphane	53,65	COX-2	70,75	sulforaphane	COX-2	MESH:C016766	5743	Chemical	Gene	START_ENTITY|nmod|ZEB1 ZEB1|compound|END_ENTITY	Epithelial-mesenchymal transition , a novel target of sulforaphane via COX-2 / MMP2 , 9/Snail , ZEB1 and miR-200c / ZEB1 pathways in human bladder_cancer cells .
15856023	0	sulforaphane	68,80	IkappaBalpha	99,111	sulforaphane	IkappaBalpha	MESH:C016766	4792	Chemical	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha , IKK pathway in human prostate_cancer PC-3 cells .
15856023	0	sulforaphane	68,80	NF-kappaB	15,24	sulforaphane	NF-kappaB	MESH:C016766	4790	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha , IKK pathway in human prostate_cancer PC-3 cells .
24416372	0	sulforaphane	10,22	NRF2	62,66	sulforaphane	NRF2	MESH:C016766	4780	Chemical	Gene	coactivator|amod|START_ENTITY coactivator|nmod|END_ENTITY	SPBP is a sulforaphane induced transcriptional coactivator of NRF2 regulating expression of the autophagy receptor p62/SQSTM1 .
18325578	0	sulforaphane	19,31	Nrf2	0,4	sulforaphane	Nrf2	MESH:C016766	18024(Tax:10090)	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Nrf2 activation by sulforaphane restores the age-related decrease of T -LRB- H -RRB- 1 immunity : role of dendritic cells .
19303893	0	sulforaphane	59,71	Nrf2	21,25	sulforaphane	Nrf2	MESH:C016766	18024(Tax:10090)	Chemical	Gene	response|acl|START_ENTITY mediates|dobj|response mediates|nsubj|END_ENTITY	Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles , peroxides and redox-cycling agents .
21358121	0	sulforaphane	177,189	Nrf2	83,87	sulforaphane	Nrf2	MESH:C016766	83619(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY essential|nmod|effects essential|nsubj|biosynthesis biosynthesis|nmod|activation activation|nmod|END_ENTITY	Glutathione biosynthesis via activation of the nuclear_factor_E2-related_factor_2 -LRB- Nrf2 -RRB- -- antioxidant-response element -LRB- ARE -RRB- pathway is essential for neuroprotective effects of sulforaphane and 6 - -LRB- methylsulfinyl -RRB- _ hexyl_isothiocyanate .
21557329	0	sulforaphane	94,106	Nrf2	10,14	sulforaphane	Nrf2	MESH:C016766	18024(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY Impact|dep|effect Impact|nmod|END_ENTITY	Impact of Nrf2 on UVB-induced skin_inflammation / photoprotection and photoprotective effect of sulforaphane .
21681606	0	sulforaphane	38,50	Nrf2	54,58	sulforaphane	Nrf2	MESH:C016766	18024(Tax:10090)	Chemical	Gene	distribution|nmod|START_ENTITY distribution|nmod|knockout knockout|amod|END_ENTITY	Metabolism and tissue distribution of sulforaphane in Nrf2 knockout and wild-type mice .
22023613	0	sulforaphane	29,41	Nrf2	0,4	sulforaphane	Nrf2	MESH:C016766	83619(Tax:10116)	Chemical	Gene	modulation|nmod|START_ENTITY modulation|amod|END_ENTITY	Nrf2 and NF-kB modulation by sulforaphane counteracts multiple manifestations of diabetic_neuropathy in rats and high glucose-induced changes .
22552270	0	sulforaphane	72,84	Nrf2	111,115	sulforaphane	Nrf2	MESH:C016766	83619(Tax:10116)	Chemical	Gene	stress|nmod|START_ENTITY stress|nmod|activation activation|nmod|translocation translocation|amod|END_ENTITY	Inhibition of 6-hydroxydopamine-induced endoplasmic reticulum stress by sulforaphane through the activation of Nrf2 nuclear translocation .
23050040	0	sulforaphane	38,50	Nrf2	69,73	sulforaphane	Nrf2	MESH:C016766	18024(Tax:10090)	Chemical	Gene	diabetic_nephropathy|nmod|START_ENTITY Prevention|nmod|diabetic_nephropathy Prevention|dep|role role|nmod|upregulation upregulation|amod|END_ENTITY	Prevention of diabetic_nephropathy by sulforaphane : possible role of Nrf2 upregulation and activation .
23353773	0	sulforaphane	14,26	Nrf2	90,94	sulforaphane	Nrf2	MESH:C016766	18024(Tax:10090)	Chemical	Gene	Prevention|nmod|START_ENTITY associated|nsubjpass|Prevention associated|nmod|up-regulation up-regulation|nmod|expression expression|amod|END_ENTITY	Prevention by sulforaphane of diabetic_cardiomyopathy is associated with up-regulation of Nrf2 expression and transcription activation .
24441674	0	sulforaphane	129,141	Nrf2	45,49	sulforaphane	Nrf2	MESH:C016766	18024(Tax:10090)	Chemical	Gene	promoter|nmod|START_ENTITY promoter|nsubj|reprogramming reprogramming|nmod|END_ENTITY	Requirement and epigenetics reprogramming of Nrf2 in suppression of tumor promoter TPA-induced mouse skin cell transformation by sulforaphane .
24603300	0	sulforaphane	32,44	Nrf2	9,13	sulforaphane	Nrf2	MESH:C016766	4780	Chemical	Gene	using|dobj|START_ENTITY stimulation|acl|using stimulation|amod|END_ENTITY	Repeated Nrf2 stimulation using sulforaphane protects fibroblasts from ionizing radiation .
24967692	0	sulforaphane	14,26	Nrf2	117,121	sulforaphane	Nrf2	MESH:C016766	18024(Tax:10090)	Chemical	Gene	apoptosis|amod|START_ENTITY Protection|nmod|apoptosis associated|nsubjpass|Protection associated|nmod|up-regulation up-regulation|nmod|expression expression|amod|END_ENTITY	Protection by sulforaphane from type 1 diabetes-induced testicular apoptosis is associated with the up-regulation of Nrf2 expression and function .
26415026	0	sulforaphane	84,96	Nrf2	118,122	sulforaphane	Nrf2	MESH:C016766	18024(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|up-regulation up-regulation|nmod|END_ENTITY	Metallothionein plays a prominent role in the prevention of diabetic_nephropathy by sulforaphane via up-regulation of Nrf2 .
26970133	0	sulforaphane	58,70	Nrf2	34,38	sulforaphane	Nrf2	MESH:C016766	4780	Chemical	Gene	rich|nmod|START_ENTITY foods|amod|rich END_ENTITY|nmod|foods	Frugal chemoprevention : targeting Nrf2 with foods rich in sulforaphane .
24910998	0	sulforaphane	34,46	STAT5	56,61	sulforaphane	STAT5	MESH:C016766	6776	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	The natural chemopreventive agent sulforaphane inhibits STAT5 activity .
24969711	0	sulforaphane	12,24	Toll-like_receptor_4	28,48	sulforaphane	Toll-like receptor 4	MESH:C016766	7099	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of sulforaphane on Toll-like_receptor_4 / myeloid_differentiation_factor_88 pathway of monocyte-derived macrophages from patients with chronic_obstructive_pulmonary_disease -RSB- .
18373608	0	sulforaphane	42,54	beta-defensin-2	69,84	sulforaphane	beta-defensin-2	MESH:C016766	1673	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	The dietary histone deacetylase inhibitor sulforaphane induces human beta-defensin-2 in intestinal epithelial cells .
16170570	0	sulforaphane	77,89	cyclin_D1	162,171	sulforaphane	cyclin D1	MESH:C016766	595	Chemical	Gene	HT-29|nmod|START_ENTITY cells|amod|HT-29 arrest|nmod|cells associated|nsubjpass|arrest associated|nmod|induction induction|nmod|p21CIP1 p21CIP1|nmod|expression expression|nmod|END_ENTITY	p53-independent G1 cell cycle arrest of human colon_carcinoma cells HT-29 by sulforaphane is associated with induction of p21CIP1 and inhibition of expression of cyclin_D1 .
27035641	0	sulforaphane	14,26	cyclin_D1	74,83	sulforaphane	cyclin D1	MESH:C016766	595	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of sulforaphane on the cell cycle , apoptosis and expression of cyclin_D1 and p21 in the A549 non-small_cell_lung_cancer cell line .
18602823	0	sulforaphane	81,93	estrogen_receptor_alpha	14,37	sulforaphane	estrogen receptor alpha	MESH:C016766	2099	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of estrogen_receptor_alpha expression in human breast_cancer cells by sulforaphane .
16951197	0	sulforaphane	23,35	heme_oxygenase-1	168,184	sulforaphane	heme oxygenase-1	MESH:C016766	3162	Chemical	Gene	action|nmod|START_ENTITY Mechanism|nmod|action Mechanism|dep|inhibition inhibition|acl|contributing contributing|nmod|induction induction|nmod|response response|amod|END_ENTITY	Mechanism of action of sulforaphane : inhibition of p38_mitogen-activated_protein_kinase isoforms contributing to the induction of antioxidant response element-mediated heme_oxygenase-1 in human hepatoma HepG2 cells .
19653226	0	sulforaphane	21,33	heme_oxygenase-1	75,91	sulforaphane	heme oxygenase-1	MESH:C016766	3162	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|amod|END_ENTITY	Protective effect of sulforaphane on indomethacin-induced cytotoxicity via heme_oxygenase-1 expression in human intestinal Int 407 cells .
15313918	0	sulforaphane	40,52	histone_deacetylase	68,87	sulforaphane	histone deacetylase	MESH:C016766	9734	Chemical	Gene	chemoprotection|nmod|START_ENTITY mechanism|nmod|chemoprotection mechanism|dep|inhibition inhibition|nmod|END_ENTITY	A novel mechanism of chemoprotection by sulforaphane : inhibition of histone_deacetylase .
19812222	0	sulforaphane	8,20	histone_deacetylase	24,43	sulforaphane	histone deacetylase	MESH:C016766	9734	Chemical	Gene	inhibitor|ccomp|START_ENTITY inhibitor|nsubj|END_ENTITY	Dietary sulforaphane , a histone_deacetylase inhibitor for cancer prevention .
25307283	0	sulforaphane	14,26	histone_deacetylase	30,49	sulforaphane	histone deacetylase	MESH:C016766	9734	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	The effect of sulforaphane on histone_deacetylase activity in keratinocytes : Differences between in vitro and in vivo analyses .
20603835	0	sulforaphane	15,27	ornithine_decarboxylase	52,75	sulforaphane	ornithine decarboxylase	MESH:C016766	4953	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	Isothiocyanate sulforaphane inhibits protooncogenic ornithine_decarboxylase activity in colorectal_cancer cells via induction of the TGF-b/Smad signaling pathway .
12663510	0	sulforaphane	16,28	thioredoxin_reductase_1	62,85	sulforaphane	thioredoxin reductase 1	MESH:C016766	7296	Chemical	Gene	START_ENTITY|nmod|induction induction|nmod|END_ENTITY	Synergy between sulforaphane and selenium in the induction of thioredoxin_reductase_1 requires both transcriptional and translational modulation .
21378177	3	sulfosuccinimidyl_oleate	586,610	CD36	570,574	sulfosuccinimidyl oleate	CD36	null	12491(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	RESEARCH DESIGN AND METHODS : In vitro , the effect of CD36 inhibition and deletion in lipid-induced macrophage inflammation was assessed using the putative CD36 inhibitor , sulfosuccinimidyl_oleate -LRB- SSO -RRB- , and bone marrow-derived macrophages from mice with -LRB- CD36KO -RRB- or without -LRB- wild-type -RRB- global deletion of CD36 .
18799424	0	sulfotyrosine	26,39	CXCR4	20,25	sulfotyrosine	CXCR4	null	7852	Chemical	Gene	START_ENTITY|nsubj|basis basis|nmod|END_ENTITY	Structural basis of CXCR4 sulfotyrosine recognition by the chemokine SDF-1 / CXCL12 .
3219192	0	sulfoxide	36,45	growth_hormone	94,108	sulfoxide	growth hormone	MESH:C005746	2688	Chemical	Gene	Isolation|nmod|START_ENTITY Isolation|nmod|END_ENTITY	Isolation and characterization of a sulfoxide and a desamido derivative of biosynthetic human growth_hormone .
7851398	0	sulfoxides	79,89	3-hydroxy-3-methylglutaryl-CoA_reductase	14,54	sulfoxides	3-hydroxy-3-methylglutaryl-CoA reductase	MESH:D013454	3156	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of 3-hydroxy-3-methylglutaryl-CoA_reductase and citrate_synthase by sulfoxides and sulfones of substrate-analogue CoA-thioether derivatives .
8675550	0	sulfoximine	34,45	gamma-glutamylcysteine_synthetase	47,80	sulfoximine	gamma-glutamylcysteine synthetase	null	25283(Tax:10116)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Determination of L-buthionin -LRB- SR -RRB- - sulfoximine , gamma-glutamylcysteine_synthetase inhibitor in rat plasma with HPLC after prelabeling with dansyl_chloride .
7642502	0	sulfur	21,27	ES-1	109,113	sulfur	ES-1	MESH:D013455	8209	Chemical	Gene	START_ENTITY|nmod|metabolism metabolism|nmod|END_ENTITY	Effects of elemental sulfur on the metabolism of the deep-sea hyperthermophilic archaeon Thermococcus strain ES-1 : characterization of a sulfur-regulated , non-heme iron_alcohol_dehydrogenase .
12359730	0	sulfur	75,81	KAP	110,113	sulfur	KAP	MESH:D013455	1033	Chemical	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	Characterization of a first domain of human high glycine-tyrosine and high sulfur keratin-associated protein -LRB- KAP -RRB- genes on chromosome 21q22 .1 .
14962103	0	sulfur	68,74	KAP	75,78	sulfur	KAP	MESH:D013455	1033	Chemical	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	Hair keratin_associated_proteins : characterization of a second high sulfur KAP gene domain on human chromosome 21 .
18326790	2	sulfur	342,348	SAC1	332,336	sulfur	SAC3	MESH:D013455	5727875(Tax:3055)	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|nmod|protein	A positive regulator , SAC1 -LRB- for sulfur acclimation protein 1 -RRB- , and a negative regulator , SAC3 , were shown to participate in the control of these processes .
16672369	0	sulfur	4,10	SAC3	23,27	sulfur	SAC3	MESH:D013455	5727875(Tax:3055)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The sulfur acclimation SAC3 kinase is required for chloroplast transcriptional repression under sulfur limitation in Chlamydomonas_reinhardtii .
19782750	0	sulfur	23,29	SS3	110,113	sulfur	SS3	MESH:D013455	100196919	Chemical	Gene	Oxidation|nmod|START_ENTITY Oxidation|nmod|END_ENTITY	Oxidation of elemental sulfur , tetrathionate and ferrous_iron by the psychrotolerant Acidithiobacillus strain SS3 .
24763424	0	sulfur	33,39	Sky1	0,4	sulfur	Sky1	MESH:D013455	855256(Tax:4932)	Chemical	Gene	genes|compound|START_ENTITY expression|nmod|genes regulates|dobj|expression regulates|nsubj|END_ENTITY	Sky1 regulates the expression of sulfur metabolism genes in response to cisplatin .
2524646	0	sulfur	27,33	cys-3	0,5	sulfur	cys-3	MESH:D013455	851221(Tax:4932)	Chemical	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	cys-3 , the positive-acting sulfur regulatory gene of Neurospora_crassa , encodes a protein with a putative leucine zipper DNA-binding element .
23265191	0	sulfur	28,34	frataxin	10,18	sulfur	frataxin	MESH:D013455	2395	Chemical	Gene	production|compound|START_ENTITY controls|dobj|production controls|nsubj|END_ENTITY	Mammalian frataxin controls sulfur production and iron entry during de novo Fe4S4 cluster assembly .
15016471	0	sulfur	46,52	glutamine_transaminase_K	12,36	sulfur	glutamine transaminase K	MESH:D013455	883	Chemical	Gene	metabolism|compound|START_ENTITY role|nmod|metabolism role|nmod|END_ENTITY	The role of glutamine_transaminase_K -LRB- GTK -RRB- in sulfur and alpha-keto_acid metabolism in the brain , and in the possible bioactivation of neurotoxicants .
26051600	0	sulfur	35,41	ii	28,30	sulfur	ii	MESH:D013455	760	Chemical	Gene	analogues|compound|START_ENTITY END_ENTITY|nmod|analogues	Improved selectivity for Pb -LRB- ii -RRB- by sulfur , selenium and tellurium analogues of 1,8-anthraquinone-18-crown-5 : synthesis , spectroscopy , X-ray crystallography and computational studies .
17761201	0	sulfur	48,54	reductase	31,40	sulfur	reductase	MESH:D013455	547911(Tax:3847)	Chemical	Gene	pathway|compound|START_ENTITY END_ENTITY|nmod|pathway	The role of 5 ' - adenylylsulfate reductase in the sulfur assimilation pathway of soybean : molecular cloning , kinetic characterization , and gene expression .
17991026	0	sulfur	125,131	soxB	60,64	sulfur	soxB	MESH:D013455	6658	Chemical	Gene	system|compound|START_ENTITY evolution|nmod|system analysis|dep|evolution analysis|nmod|distribution distribution|nmod|gene gene|amod|END_ENTITY	Molecular analysis of the distribution and phylogeny of the soxB gene among sulfur-oxidizing bacteria - evolution of the Sox sulfur oxidation enzyme system .
18832027	0	sulfur	80,86	soxB	103,107	sulfur	soxB	MESH:D013455	6658	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Chemolithoautotrophic oxidation of thiosulfate and phylogenetic distribution of sulfur oxidation gene -LRB- soxB -RRB- in rhizobacteria isolated from crop plants .
12538647	0	sulfur	64,70	transthyretin	84,97	sulfur	transthyretin	MESH:D013455	7276	Chemical	Gene	oxidation|compound|START_ENTITY oxidation|nmod|END_ENTITY	X-ray absorption spectroscopy reveals a substantial increase of sulfur oxidation in transthyretin -LRB- TTR -RRB- upon fibrillization .
17590487	0	sulfur_dioxide	11,25	MUC5AC	48,54	sulfur dioxide	MUC5AC	MESH:D013458	682837(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expressions expressions|nmod|END_ENTITY	Effects of sulfur_dioxide on the expressions of MUC5AC and ICAM-1 in airway of asthmatic rats .
19681733	0	sulfur_dioxide	11,25	p53	44,47	sulfur dioxide	p53	MESH:D013458	301300(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expressions expressions|nmod|END_ENTITY	Effects of sulfur_dioxide on expressions of p53 , bax and bcl-2 in lungs of asthmatic rats .
11861373	0	sulindac	40,48	signal_transducer_and_activator_of_transcription_3	75,125	sulindac	signal transducer and activator of transcription 3	MESH:D013467	6774	Chemical	Gene	causes|nsubj|START_ENTITY causes|dobj|down-regulation down-regulation|nmod|END_ENTITY	The nonsteroidal anti-inflammatory drug sulindac causes down-regulation of signal_transducer_and_activator_of_transcription_3 in human oral_squamous_cell_carcinoma cells .
19934343	0	sulindac_sulfide	29,45	EP4	55,58	sulindac sulfide	EP4	MESH:C025462	5734	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	The cyclooxygenase inhibitor sulindac_sulfide inhibits EP4 expression and suppresses the growth of glioblastoma cells .
24080406	0	sulindac_sulfide	36,52	Nesprin-2	83,92	sulindac sulfide	Nesprin-2	MESH:C025462	23224	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Nonsteroidal anti-inflammatory drug sulindac_sulfide suppresses structural protein Nesprin-2 expression in colorectal_cancer cells .
17191008	0	sulodexide	10,20	NAG	37,40	sulodexide	NAG	MESH:C007858	10724	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of sulodexide on albuminuria , NAG excretion and glomerular filtration response to dopamine in diabetic patients .
26477504	0	sulodexide	93,103	Superoxide_dismutase_1	0,22	sulodexide	Superoxide dismutase 1	MESH:C007858	6647	Chemical	Gene	effect|nmod|START_ENTITY involved|nmod|effect involved|nsubjpass|END_ENTITY	Superoxide_dismutase_1 and glutathione_peroxidase_1 are involved in the protective effect of sulodexide on vascular endothelial cells exposed to oxygen-glucose_deprivation .
19117965	0	sulodexide	10,20	transforming_growth_factor-beta1	31,63	sulodexide	transforming growth factor-beta1	MESH:C007858	7040	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of sulodexide on plasma transforming_growth_factor-beta1 in healthy volunteers .
11050699	0	sulphate	55,63	Desmin	65,71	sulphate	Desmin	CHEBI:16189	1674	Chemical	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Pharmacodynamic study of low molecular weight dermatan sulphate -LRB- Desmin -RRB- after a single subcutaneous administration in patients with renal_insufficiency .
9560328	0	sulphate	81,89	PG-Lb	45,50	sulphate	PG-Lb	CHEBI:16189	13516(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|structure structure|nmod|END_ENTITY	The gene structure and organization of mouse PG-Lb , a small chondroitin/dermatan sulphate proteoglycan .
2963617	0	sulphate	26,34	antithrombin	58,70	sulphate	antithrombin	CHEBI:16189	462	Chemical	Gene	START_ENTITY|nmod|affinity affinity|nmod|END_ENTITY	Basement-membrane heparan sulphate with high affinity for antithrombin synthesized by normal and transformed mouse mammary epithelial cells .
11533660	0	sulphate	56,64	fringe_connection	17,34	sulphate	fringe connection	CHEBI:16189	39943(Tax:7227)	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Dual role of the fringe_connection gene in both heparan sulphate and fringe-dependent signalling events .
6180601	0	sulphate	39,47	plasmin	51,58	sulphate	plasmin	CHEBI:16189	5340	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Effect of low molecular weight dextran sulphate on plasmin activity measured with S-2251 .
16162679	0	sulphate_sodium	53,68	interleukin_15	8,22	sulphate sodium	interleukin 15	null	16168(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Role Role|nmod|END_ENTITY	Role of interleukin_15 in colitis induced by dextran sulphate_sodium in mice .
9068899	0	sulphates	84,93	heparin_cofactor_II	36,55	sulphates	heparin cofactor II	CHEBI:35175	3053	Chemical	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	Mechanism of thrombin inhibition by heparin_cofactor_II in the presence of dermatan sulphates , native or oversulphated , and a heparin-like dextran derivative .
469001	0	sulphates	18,27	thrombin	31,39	sulphates	thrombin	CHEBI:35175	2147	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Effect of dextran sulphates on thrombin activity .
1575993	0	sulphates	26,35	tumour_necrosis_factor	66,88	sulphates	tumour necrosis factor	CHEBI:35175	21926(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Priming effect of dextran sulphates on lipopolysaccharide-induced tumour_necrosis_factor production in mice .
1816051	0	sulphite	40,48	rhodanese	25,34	sulphite	rhodanese	CHEBI:17359	280946(Tax:9913)	Chemical	Gene	modification|nmod|START_ENTITY modification|nmod|END_ENTITY	Chemical modification of rhodanese with sulphite .
26392244	0	sulphobutylether_b-cyclodextrins	56,88	tank	11,15	sulphobutylether b-cyclodextrins	tank	null	10010	Chemical	Gene	synthesis|nmod|START_ENTITY synthesis|compound|END_ENTITY	Continuous tank reactor synthesis of highly substituted sulphobutylether_b-cyclodextrins .
19768461	0	sulphonated_anthraquinones	14,40	P450	95,99	sulphonated anthraquinones	P450	null	542163(Tax:4577)	Chemical	Gene	Metabolism|nmod|START_ENTITY Metabolism|dep|role role|nmod|END_ENTITY	Metabolism of sulphonated_anthraquinones in rhubarb , maize and celery : the role of cytochromes P450 and peroxidases .
12927860	0	sulphonyl	29,38	COX-2	39,44	sulphonyl	COX-2	null	4513	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Computer-aided design of non sulphonyl COX-2 inhibitors : an improved comparative molecular field analysis incorporating additional descriptors and comparative molecular similarity indices analysis of 1,3-diarylisoindole derivatives .
10454046	0	sulphonylcyanoguanidine	55,78	Thromboxane_A2_receptor	0,23	sulphonylcyanoguanidine	Thromboxane A2 receptor	null	6915	Chemical	Gene	antagonism|nmod|START_ENTITY antagonism|nsubj|END_ENTITY	Thromboxane_A2_receptor antagonism in man and rat by a sulphonylcyanoguanidine -LRB- BM-144 -RRB- and a sulphonylurea -LRB- BM-500 -RRB- .
10570926	0	sulphonylurea	96,109	SUR1	120,124	sulphonylurea	SUR1	null	6833	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	NEM modification prevents high-affinity ATP binding to the first nucleotide binding fold of the sulphonylurea receptor , SUR1 .
1777653	0	sulphonylurea	10,23	insulin	46,53	sulphonylurea	insulin	null	3630	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Effect of sulphonylurea on glucose-stimulated insulin secretion in healthy and non-insulin dependent diabetic subjects : a dose-response study .
17976204	0	sulphonylurea	51,64	insulin	38,45	sulphonylurea	insulin	null	3630	Chemical	Gene	therapy|compound|START_ENTITY END_ENTITY|nmod|therapy	Glycaemic responsiveness to long-term insulin plus sulphonylurea therapy as assessed by sulphonylurea withdrawal .
8033529	0	sulphonylurea	10,23	insulin	42,49	sulphonylurea	insulin	null	3630	Chemical	Gene	therapy|compound|START_ENTITY therapy|nmod|END_ENTITY	Effect of sulphonylurea therapy on plasma insulin , intact and 32/33 split proinsulin in subjects with type_2_diabetes_mellitus .
10810315	0	sulphonylureas	28,42	neuropeptide_Y	65,79	sulphonylureas	neuropeptide Y	null	24604(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|nmod|END_ENTITY	Glibenclamide but not other sulphonylureas stimulates release of neuropeptide_Y from perifused rat islets and hamster_insulinoma cells .
2262933	0	sulphydryl	29,39	insulin_receptor	12,28	sulphydryl	insulin receptor	null	24954(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	The role of insulin_receptor sulphydryl groups in insulin binding and cellular response in rat adipocytes .
17912501	0	sulpiride	47,56	Dopamine_D2_receptor	0,20	sulpiride	Dopamine D2 receptor	MESH:D013469	1813	Chemical	Gene	levels|nmod|START_ENTITY levels|amod|END_ENTITY	Dopamine_D2_receptor occupancy levels of acute sulpiride challenges that produce working memory_and_learning_impairments in healthy volunteers .
3108355	0	sulpiride	39,48	Prolactin	0,9	sulpiride	Prolactin	MESH:D013469	5617	Chemical	Gene	administration|amod|START_ENTITY unresponsiveness|nmod|administration unresponsiveness|nsubj|END_ENTITY	Prolactin unresponsiveness to repeated sulpiride administration in man : recent findings .
3620290	0	sulpiride	31,40	Prolactin	0,9	sulpiride	Prolactin	MESH:D013469	5617	Chemical	Gene	START_ENTITY|nsubj|response response|compound|END_ENTITY	Prolactin response to low dose sulpiride .
3888233	0	sulpiride	22,31	Prolactin	0,9	sulpiride	Prolactin	MESH:D013469	5617	Chemical	Gene	START_ENTITY|nsubj|response response|compound|END_ENTITY	Prolactin response to sulpiride in non_insulin_dependent_diabetes_mellitus .
6146579	0	sulpiride	22,31	Prolactin	0,9	sulpiride	Prolactin	MESH:D013469	5617	Chemical	Gene	response|acl|START_ENTITY response|nsubj|END_ENTITY	Prolactin response to sulpiride in ovulatory women -LRB- a clue for the screening of hyperprolactinemic states -RRB- .
6642291	0	sulpiride	47,56	Prolactin	0,9	sulpiride	Prolactin	MESH:D013469	5617	Chemical	Gene	START_ENTITY|nsubj|response response|compound|END_ENTITY	Prolactin response to the dopamine antagonists sulpiride and domperidone .
6805007	0	sulpiride	101,110	Prolactin	0,9	sulpiride	Prolactin	MESH:D013469	5617	Chemical	Gene	relation|acl|START_ENTITY response|nmod|relation response|compound|END_ENTITY	Prolactin response following intravenous and oral sulpiride in healthy human subjects in relation to sulpiride concentrations .
6805007	0	sulpiride	50,59	Prolactin	0,9	sulpiride	Prolactin	MESH:D013469	5617	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Prolactin response following intravenous and oral sulpiride in healthy human subjects in relation to sulpiride concentrations .
7327523	0	sulpiride	58,67	Prolactin	0,9	sulpiride	Prolactin	MESH:D013469	5617	Chemical	Gene	doses|nmod|START_ENTITY responsiveness|nmod|doses responsiveness|nsubj|END_ENTITY	Prolactin responsiveness to repeated decremental doses of sulpiride .
9110224	0	sulpiride	62,71	Prolactin	0,9	sulpiride	Prolactin	MESH:D013469	5617	Chemical	Gene	administration|compound|START_ENTITY shedding|nmod|administration END_ENTITY|acl|shedding	Prolactin , gonadotropin , and hair shedding responses to daily sulpiride administration in geldings in winter .
563826	0	sulpiride	35,44	gastrin	14,21	sulpiride	gastrin	MESH:D013469	2520	Chemical	Gene	treatment|amod|START_ENTITY secretion|nmod|treatment secretion|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of gastrin secretion by sulpiride treatment in duodenal ulcer patients .
989340	0	sulpiride	10,19	gastrin	29,36	sulpiride	gastrin	MESH:D013469	2520	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of sulpiride on serum gastrin in duodenal ulcer .
406134	0	sulpiride	10,19	growth_hormone	29,43	sulpiride	growth hormone	MESH:D013469	2688	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of sulpiride on serum growth_hormone and prolactin concentrations following L-DOPA administration in man .
7139355	0	sulpiride	10,19	growth_hormone	69,83	sulpiride	growth hormone	MESH:D013469	2688	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of sulpiride , an atypical neuroleptic , on apomorphine-induced growth_hormone secretion .
7296596	0	sulpiride	24,33	growth_hormone	45,59	sulpiride	growth hormone	MESH:D013469	2688	Chemical	Gene	therapy|compound|START_ENTITY therapy|nmod|secretion secretion|amod|END_ENTITY	Effects of long-lasting sulpiride therapy on growth_hormone secretion in mentally disturbed children .
1018732	0	sulpiride	10,19	prolactin	30,39	sulpiride	prolactin	MESH:D013469	24683(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of sulpiride on plasma prolactin in rats .
1020923	0	sulpiride	49,58	prolactin	62,71	sulpiride	prolactin	MESH:D013469	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	-LSB- Ultrastructural study of stimulation induced by sulpiride on prolactin and gonadotrope cells of hypophysis in male and female rats -LRB- author 's transl -RRB- -RSB- .
11998830	0	sulpiride	18,27	prolactin	71,80	sulpiride	prolactin	MESH:D013469	5617	Chemical	Gene	anovulatory|amod|START_ENTITY mares|amod|anovulatory Administration|nmod|mares Administration|dep|effects effects|nmod|ovulation ovulation|compound|END_ENTITY	Administration of sulpiride to anovulatory mares in winter : effects on prolactin and gonadotropin concentrations , ovarian activity , ovulation and hair shedding .
1249187	0	sulpiride	10,19	prolactin	29,38	sulpiride	prolactin	MESH:D013469	5617	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|compound|END_ENTITY	Effect of sulpiride on serum prolactin levels in humans .
1938655	0	sulpiride	184,193	prolactin	35,44	sulpiride	prolactin	MESH:D013469	5617	Chemical	Gene	treatment|amod|START_ENTITY luteinizing|nmod|treatment concentrations|acl|luteinizing concentrations|acl|END_ENTITY	Plasma concentrations of cortisol , prolactin , luteinizing hormone , and follicle-stimulating hormone in stallions after physical exercise and injection of secretagogue before and after sulpiride treatment in winter .
21571	0	sulpiride	51,60	prolactin	79,88	sulpiride	prolactin	MESH:D013469	5617	Chemical	Gene	agent|appos|START_ENTITY evaluation|nmod|agent evaluation|dep|effects effects|nmod|END_ENTITY	An evaluation of a unique new antipsychotic agent , sulpiride : effects on serum prolactin and growth_hormone levels .
2949800	0	sulpiride	11,20	prolactin	40,49	sulpiride	prolactin	MESH:D013469	24683(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|release release|compound|END_ENTITY	Effects of sulpiride and apomorphine on prolactin release in adrenalectomized animals .
3785645	0	sulpiride	10,19	prolactin	30,39	sulpiride	prolactin	MESH:D013469	5617	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of sulpiride on plasma prolactin in healthy volunteers and depressed patients .
4089188	0	sulpiride	68,77	prolactin	30,39	sulpiride	prolactin	MESH:D013469	5617	Chemical	Gene	doses|nmod|START_ENTITY response|nmod|doses response|compound|END_ENTITY	Effect of normal aging on the prolactin response to graded doses of sulpiride and to arginine .
410826	0	sulpiride	74,83	prolactin	52,61	sulpiride	prolactin	MESH:D013469	5617	Chemical	Gene	suppress|advcl|START_ENTITY suppress|dobj|response response|compound|END_ENTITY	Failure of dopamine infusion to suppress the plasma prolactin response to sulpiride in normal and hyperprolactinemic subjects .
474034	0	sulpiride	60,69	prolactin	38,47	sulpiride	prolactin	MESH:D013469	5617	Chemical	Gene	hypoglycaemia|compound|START_ENTITY Study|nmod|hypoglycaemia Study|nmod|reproducibility reproducibility|nmod|response response|compound|END_ENTITY	Study on the reproducibility of human prolactin response to sulpiride , benserazide , insulin hypoglycaemia and arginine infusion .
578053	0	sulpiride	42,51	prolactin	19,28	sulpiride	prolactin	MESH:D013469	5617	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|stimulation stimulation|nmod|END_ENTITY	The stimulation of prolactin secretion by sulpiride in `` adolescent gynaecomastia '' .
639331	0	sulpiride	63,72	prolactin	14,23	sulpiride	prolactin	MESH:D013469	5617	Chemical	Gene	test|amod|START_ENTITY release|nmod|test release|nsubj|Assessment Assessment|nmod|END_ENTITY	Assessment of prolactin release in pituitary_dwarfism with the sulpiride test .
6439566	0	sulpiride	61,70	prolactin	22,31	sulpiride	prolactin	MESH:D013469	5617	Chemical	Gene	administration|amod|START_ENTITY unresponsiveness|nmod|administration unresponsiveness|nsubj|mechanism mechanism|nmod|END_ENTITY	Possible mechanism of prolactin unresponsiveness to repeated sulpiride administration in man .
6628512	0	sulpiride	55,64	prolactin	20,29	sulpiride	prolactin	MESH:D013469	5617	Chemical	Gene	injection|nmod|START_ENTITY END_ENTITY|nmod|injection	Unresponsiveness of prolactin to repeated injection of sulpiride in man .
6648972	0	sulpiride	14,23	prolactin	68,77	sulpiride	prolactin	MESH:D013469	24683(Tax:10116)	Chemical	Gene	administration|amod|START_ENTITY administration|nmod|levels levels|compound|END_ENTITY	The effect of sulpiride administration on maternal and fetal plasma prolactin levels , and fetal growth in rats .
6789593	0	sulpiride	47,56	prolactin	22,31	sulpiride	prolactin	MESH:D013469	5617	Chemical	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Dynamic evaluation of prolactin secretion with sulpiride and thyrotrophin releasing hormone in amenorrhoeic and normally menstruating women .
680182	0	sulpiride	49,58	prolactin	11,20	sulpiride	prolactin	MESH:D013469	5617	Chemical	Gene	effect|nmod|START_ENTITY Release|dep|effect Release|nmod|END_ENTITY	Release of prolactin during pregnancy : effect of sulpiride .
6873386	0	sulpiride	11,20	prolactin	69,78	sulpiride	prolactin	MESH:D013469	24683(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|regulation regulation|nmod|formation formation|amod|END_ENTITY	-LSB- Effect of sulpiride on the hypothalamic monoaminergic regulation of prolactin formation and milk secretion -RSB- .
7435113	0	sulpiride	10,19	prolactin	30,39	sulpiride	prolactin	MESH:D013469	5617	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|compound|END_ENTITY	Effect of sulpiride on plasma prolactin levels in women with puerperal or pathological hyperprolactinaemia .
7459063	0	sulpiride	138,147	prolactin	92,101	sulpiride	prolactin	MESH:D013469	5617	Chemical	Gene	-RSB-|amod|START_ENTITY effects|nmod|-RSB- Stereospecificity|dep|effects Stereospecificity|nmod|receptors receptors|acl|involved involved|nmod|control control|nmod|secretion secretion|compound|END_ENTITY	-LSB- Stereospecificity of hypothalamo-hypophysial dopamine receptors involved in the control of prolactin secretion in normal man : effects of sulpiride stereoisomers -RSB- .
813995	0	sulpiride	44,53	prolactin	21,30	sulpiride	prolactin	MESH:D013469	5617	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Stimulation Stimulation|nmod|END_ENTITY	Stimulation of human prolactin secretion by sulpiride .
1121507	0	sulpride	29,37	prolactin	47,56	sulpride	prolactin	null	24683(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Acute and chronic effects of sulpride on serum prolactin and gonadotropin levels in castrated male rats -LRB- 38581 -RRB- .
6424592	0	sultopride	10,20	prolactin	24,33	sultopride	prolactin	MESH:C012052	24683(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of sultopride on prolactin secretion in rats .
7640145	0	sumatriptan	20,31	ACTH	74,78	sumatriptan	ACTH	MESH:D018170	5443	Chemical	Gene	effects|nmod|START_ENTITY effects|acl|circulating circulating|dobj|END_ENTITY	The effects of oral sumatriptan , a 5-HT1 receptor agonist , on circulating ACTH and cortisol concentrations in man .
9193738	0	sumatriptan	27,38	Growth_hormone	0,14	sumatriptan	Growth hormone	MESH:D018170	2688	Chemical	Gene	response|acl|START_ENTITY response|amod|END_ENTITY	Growth_hormone response to sumatriptan -LRB- 5-HT1D agonist -RRB- challenge in seasonal_affective_disorder : effects of light therapy .
26659468	0	sumatriptan	32,43	OCT1	65,69	sumatriptan	OCT1	MESH:D018170	6580	Chemical	Gene	polymorphisms|compound|START_ENTITY polymorphisms|compound|END_ENTITY	OCT1 mediates hepatic uptake of sumatriptan and loss-of-function OCT1 polymorphisms affect sumatriptan pharmacokinetics .
10808042	0	sumatriptan	37,48	growth_hormone	10,24	sumatriptan	growth hormone	MESH:D018170	2688	Chemical	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Increased growth_hormone response to sumatriptan challenge in adult autistic_disorders .
17217931	0	sumatriptan	91,102	growth_hormone	63,77	sumatriptan	growth hormone	MESH:D018170	2688	Chemical	Gene	predict|xcomp|START_ENTITY predict|dobj|responses responses|amod|END_ENTITY	Diplotypes of the human serotonin 1B receptor promoter predict growth_hormone responses to sumatriptan in abstinent alcohol-dependent men .
19825906	0	sumatriptan	80,91	growth_hormone	53,67	sumatriptan	growth hormone	MESH:D018170	2688	Chemical	Gene	blunted|nmod|START_ENTITY blunted|dobj|response response|amod|END_ENTITY	Serotonin function in pathological gambling : blunted growth_hormone response to sumatriptan .
8786727	0	sumatriptan	52,63	growth_hormone	25,39	sumatriptan	growth hormone	MESH:D018170	2688	Chemical	Gene	response|acl|START_ENTITY response|amod|END_ENTITY	Alcoholism abolishes the growth_hormone response to sumatriptan administration in man .
9233053	0	sumatriptan	11,22	growth_hormone	70,84	sumatriptan	growth hormone	MESH:D018170	2688	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of sumatriptan on growth_hormone_releasing_hormone-stimulated growth_hormone secretion in acromegaly .
25637219	0	sunitinib	22,31	AXL	0,3	sunitinib	AXL	MESH:C473478	558	Chemical	Gene	response|amod|START_ENTITY modulator|nmod|response END_ENTITY|nmod|modulator	AXL as a modulator of sunitinib response in glioblastoma cell lines .
22671963	0	sunitinib	89,98	C-reactive_protein	0,18	sunitinib	C-reactive protein	MESH:C473478	1401	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|END_ENTITY	C-reactive_protein as a prognostic marker for advanced_renal_cell_carcinoma treated with sunitinib .
24215209	0	sunitinib	123,132	C-reactive_protein	36,54	sunitinib	C-reactive protein	MESH:C473478	1401	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|impact impact|nmod|END_ENTITY	Prognostic impact of baseline serum C-reactive_protein in patients with metastatic_renal_cell_carcinoma -LRB- RCC -RRB- treated with sunitinib .
21057538	0	sunitinib	69,78	Fibroblast_growth_factor_2	0,26	sunitinib	Fibroblast growth factor 2	MESH:C473478	2247	Chemical	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Fibroblast_growth_factor_2 regulates endothelial cell sensitivity to sunitinib .
23679326	0	sunitinib	120,129	IFN-alpha	150,159	sunitinib	IFN-alpha	MESH:C473478	3439	Chemical	Gene	treatment|compound|START_ENTITY treatment|nmod|END_ENTITY	Prognostic and predictive value of hematologic parameters in patients with metastatic_renal_cell_carcinoma : second line sunitinib treatment following IFN-alpha .
20103651	0	sunitinib	58,67	Interleukin-8	0,13	sunitinib	Interleukin-8	MESH:C473478	3576	Chemical	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Interleukin-8 mediates resistance to antiangiogenic agent sunitinib in renal_cell_carcinoma .
23455880	0	sunitinib	32,41	KRAS	0,4	sunitinib	KRAS	MESH:C473478	3845	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	KRAS allel-specific activity of sunitinib in an isogenic_disease model of colorectal_cancer .
25575050	0	sunitinib	15,24	PD-L1	47,52	sunitinib	PD-L1	MESH:C473478	60533(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expressions expressions|nmod|END_ENTITY	-LSB- Inhibition of sunitinib on the expressions of PD-L1 and PD-L2 of mouse bone marrow-derived dendritic cells -RSB- .
20137855	0	sunitinib	58,67	TRAIL	32,37	sunitinib	TRAIL	MESH:C473478	8743	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Synergistic antitumor effect of TRAIL in combination with sunitinib in vitro and in vivo .
25200065	0	sunitinib	29,38	Twist1	0,6	sunitinib	Twist1	MESH:C473478	22160(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY expression|acl|induced expression|amod|END_ENTITY	Twist1 expression induced by sunitinib accelerates tumor cell vasculogenic mimicry by increasing the population of CD133 + cells in triple-negative_breast_cancer .
17605814	0	sunitinib	62,71	VEGF	136,140	sunitinib	VEGF	MESH:C473478	7422	Chemical	Gene	biomarkers|nmod|START_ENTITY biomarkers|dep|modulation modulation|nmod|END_ENTITY	Circulating protein biomarkers of pharmacodynamic activity of sunitinib in patients with metastatic_renal_cell_carcinoma : modulation of VEGF and VEGF-related proteins .
18981453	0	sunitinib	33,42	VEGF	66,70	sunitinib	VEGF	MESH:C473478	83785(Tax:10116)	Chemical	Gene	evaluation|nmod|START_ENTITY evaluation|dep|inhibitor inhibitor|nmod|FLT3 FLT3|compound|END_ENTITY	Nonclinical safety evaluation of sunitinib : a potent inhibitor of VEGF , PDGF , KIT , FLT3 , and RET receptors .
20471160	0	sunitinib	60,69	VEGF	42,46	sunitinib	VEGF	MESH:C473478	7422	Chemical	Gene	counteracts|nmod|START_ENTITY counteracts|dobj|induction induction|amod|END_ENTITY	mTOR inhibition by everolimus counteracts VEGF induction by sunitinib and improves anti-tumor activity against gastric_cancer in vivo .
20676744	0	sunitinib	44,53	VEGF	0,4	sunitinib	VEGF	MESH:C473478	7422	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|END_ENTITY	VEGF pathway inhibition by anticancer agent sunitinib and susceptibility to atherosclerosis plaque disruption .
21882181	0	sunitinib	170,179	VEGF	15,19	sunitinib	VEGF	MESH:C473478	7422	Chemical	Gene	treated|nmod|START_ENTITY Association|acl|treated Association|nmod|polymorphisms polymorphisms|compound|END_ENTITY	Association of VEGF and VEGFR2 single nucleotide polymorphisms with hypertension and clinical outcome in metastatic clear_cell_renal_cell_carcinoma patients treated with sunitinib .
23154434	0	sunitinib	88,97	VEGF	60,64	sunitinib	VEGF	MESH:C473478	7422	Chemical	Gene	therapy|amod|START_ENTITY Changes|nmod|therapy Changes|acl|circulating circulating|dobj|cytokines cytokines|amod|other other|nmod|END_ENTITY	Changes in circulating pro-angiogenic cytokines , other than VEGF , before progression to sunitinib therapy in advanced renal_cell_carcinoma patients .
23511629	0	sunitinib	116,125	VEGF	0,4	sunitinib	VEGF	MESH:C473478	7422	Chemical	Gene	receiving|dobj|START_ENTITY patients|acl|receiving affect|nmod|patients affect|nsubj|polymorphisms polymorphisms|compound|END_ENTITY	VEGF and VEGFR polymorphisms affect clinical outcome in advanced renal_cell_carcinoma patients receiving first-line sunitinib .
24222145	0	sunitinib	32,41	VEGF	0,4	sunitinib	VEGF	MESH:C473478	7422	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	VEGF expression and response to sunitinib in patients with metastatic clear_cell_renal_cell_carcinoma .
24249435	14	sunitinib	1964,1973	VEGF	2009,2013	sunitinib	VEGF	MESH:C473478	7422	Chemical	Gene	treated|nmod|START_ENTITY Patients|acl|treated had|nsubj|Patients had|dobj|change change|nmod|level level|compound|END_ENTITY	Patients treated with sunitinib had no significant change in their VEGF level , but the sVEGFR2 level significantly decreased after cycles 1 and 2 -LRB- P < .0001 -RRB- and at the time of disease progression -LRB- P = .0002 -RRB- .
24414551	14	sunitinib	1932,1941	VEGF	1903,1907	sunitinib	VEGF	MESH:C473478	7422	Chemical	Gene	exposure|amod|START_ENTITY increased|nmod|exposure increased|nsubj|levels levels|compound|END_ENTITY	As predicted , VEGF levels increased during sunitinib exposure followed by a rapid decline after bevacizumab .
25145356	0	sunitinib	37,46	VEGF	19,23	sunitinib	VEGF	MESH:C473478	22339(Tax:10090)	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Blocking autocrine VEGF signaling by sunitinib , an anti-cancer drug , promotes embryonic stem cell self-renewal and somatic cell reprogramming .
25983863	0	sunitinib	43,52	VEGF	56,60	sunitinib	VEGF	MESH:C473478	7422	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Thrombotic_microangiopathy associated with sunitinib , a VEGF inhibitor , in a patient with factor V Leiden mutation .
23421954	0	sunitinib	125,134	VEGFR1	0,6	sunitinib	VEGFR1	MESH:C473478	2321	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|polymorphisms polymorphisms|nummod|END_ENTITY	VEGFR1 single nucleotide polymorphisms associated with outcome in patients with metastatic_renal_cell_carcinoma treated with sunitinib - a multicentric retrospective analysis .
21427062	0	sunitinib	18,27	interleukin-8	143,156	sunitinib	interleukin-8	MESH:C473478	3576	Chemical	Gene	study|nmod|START_ENTITY ineligible|nsubj|study ineligible|xcomp|receive receive|dobj|chemotherapy chemotherapy|dep|END_ENTITY	Phase II study of sunitinib as first-line treatment of urothelial_cancer patients ineligible to receive cisplatin-based chemotherapy : baseline interleukin-8 and tumor contrast enhancement as potential predictive factors of activity .
19767240	0	sunitinib	93,102	vascular_endothelial_growth_factor_receptor	22,65	sunitinib	vascular endothelial growth factor receptor	MESH:C473478	3791	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Risk of bleeding with vascular_endothelial_growth_factor_receptor tyrosine-kinase inhibitors sunitinib and sorafenib : a systematic review and meta-analysis of clinical trials .
20173383	0	sunitinib_malate	106,122	pro-brain_natriuretic_peptide	18,47	sunitinib malate	pro-brain natriuretic peptide	MESH:C473478	4879	Chemical	Gene	therapy|amod|START_ENTITY END_ENTITY|nmod|therapy	Plasma N-terminal pro-brain_natriuretic_peptide as prognostic marker in fatal cardial_decompensation with sunitinib_malate therapy .
19923406	0	superoxide	72,82	ANG_II	44,50	superoxide	ANG II	MESH:D013481	24179(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY END_ENTITY|nmod|inhibition	Attenuation of renal excretory responses to ANG_II during inhibition of superoxide dismutase in anesthetized rats .
14757147	0	superoxide	26,36	AT1A	69,73	superoxide	AT1A	MESH:D013481	11607(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Angiotensin_II stimulates superoxide production via both angiotensin AT1A and AT1B receptors in mouse aorta and heart .
12837686	0	superoxide	36,46	Angiotensin_II	0,14	superoxide	Angiotensin II	MESH:D013481	183	Chemical	Gene	generation|compound|START_ENTITY mediates|dobj|generation mediates|nsubj|END_ENTITY	Angiotensin_II mediates LDL-induced superoxide generation in mesangial cells .
19081082	0	superoxide	23,33	Angiotensin_II	0,14	superoxide	Angiotensin II	MESH:D013481	24179(Tax:10116)	Chemical	Gene	generation|amod|START_ENTITY oxidase|nsubj|generation induces|ccomp|oxidase induces|nsubj|END_ENTITY	Angiotensin_II induces superoxide generation via NAD -LRB- P -RRB- H oxidase activation in isolated rat pancreatic islets .
19846752	0	superoxide	112,122	Angiotensin_II	0,14	superoxide	Angiotensin II	MESH:D013481	24179(Tax:10116)	Chemical	Gene	involvement|nmod|START_ENTITY enhances|parataxis|involvement enhances|nsubj|END_ENTITY	Angiotensin_II enhances hyperpolarization-activated currents in rat aortic baroreceptor neurons : involvement of superoxide .
20448043	0	superoxide	47,57	Angiotensin_II	0,14	superoxide	Angiotensin II	MESH:D013481	24179(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY ascending|dobj|production stimulates|xcomp|ascending stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates thick ascending limb superoxide production via protein_kinase_C -LRB- a -RRB- - dependent NADPH oxidase activation .
22875785	0	superoxide	26,36	Angiotensin_II	0,14	superoxide	Angiotensin II	MESH:D013481	11606(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates superoxide production in the thick ascending limb by activating NOX4 .
26884476	0	superoxide	26,36	Angiotensin_II	0,14	superoxide	Angiotensin II	MESH:D013481	24179(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates superoxide production by nitric_oxide synthase in thick ascending limbs .
9734602	0	superoxide	23,33	Angiotensin_II	0,14	superoxide	Angiotensin II	MESH:D013481	183	Chemical	Gene	production|amod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Angiotensin_II induces superoxide anion production by mesangial cells .
25363644	0	superoxide	15,25	BRAF	46,50	superoxide	BRAF	MESH:D013481	673	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of superoxide and nitric_oxide in BRAF -LRB- V600E -RRB- inhibitor PLX4032-induced growth inhibition of melanoma cells .
3039121	0	superoxide	60,70	Beta-endorphin	0,14	superoxide	Beta-endorphin	MESH:D013481	5443	Chemical	Gene	production|compound|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Beta-endorphin stimulates human polymorphonuclear leukocyte superoxide production via a stereoselective opiate receptor .
2156873	0	superoxide	19,29	Bradykinin	0,10	superoxide	Bradykinin	MESH:D013481	3827	Chemical	Gene	release|amod|START_ENTITY induces|dobj|release induces|nsubj|END_ENTITY	Bradykinin induces superoxide anion release from human endothelial cells .
9192738	0	superoxide	44,54	CD38	69,73	superoxide	CD38	MESH:D013481	952	Chemical	Gene	generation|compound|START_ENTITY generation|nmod|END_ENTITY	Potentiation of chemotactic peptide-induced superoxide generation by CD38 ligation in human myeloid cell lines .
1525175	0	superoxide	10,20	Catalase	0,8	superoxide	Catalase	MESH:D013481	847	Chemical	Gene	dismutase|nsubj|START_ENTITY dismutase|advmod|END_ENTITY	Catalase , superoxide dismutase and glutathione peroxidase activities of lung and liver during human development .
7969855	0	superoxide	10,20	Catalase	0,8	superoxide	Catalase	MESH:D013481	24248(Tax:10116)	Chemical	Gene	dismutase|nsubj|START_ENTITY dismutase|advmod|END_ENTITY	Catalase , superoxide dismutase and glutathione peroxidase activity in neutrophils of sham-operated and olfactory-bulbectomised rats following chronic treatment with desipramine and lithium_chloride .
8107531	0	superoxide	45,55	Corticotropin-releasing_hormone	0,31	superoxide	Corticotropin-releasing hormone	MESH:D013481	100301553(Tax:9986)	Chemical	Gene	production|amod|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	Corticotropin-releasing_hormone enhances the superoxide anion production of rabbit peritoneal macrophages stimulated with N-formyl-methionyl-leucyl-phenylalanine .
16087472	0	superoxide	24,34	Cyclosporin_A	0,13	superoxide	Cyclosporin A	MESH:D013481	1161	Chemical	Gene	generates|dobj|START_ENTITY generates|nsubj|END_ENTITY	Cyclosporin_A generates superoxide in smooth muscle cells .
23977988	0	superoxide	20,30	EC-SOD	42,48	superoxide	EC-SOD	MESH:D013481	6649	Chemical	Gene	START_ENTITY|dobj|expression expression|appos|END_ENTITY	Human extracellular superoxide dismutase -LRB- EC-SOD -RRB- expression in transgenic chicken .
17032007	2	superoxide	279,289	ECSOD	301,306	superoxide	ECSOD	MESH:D013481	6649	Chemical	Gene	dismutase|compound|START_ENTITY dismutase|appos|END_ENTITY	Extracellular superoxide dismutase -LRB- ECSOD -RRB- is an antioxidant enzyme secreted by cells to prevent overproduction of reactive oxygen species .
12600921	0	superoxide	32,42	Endothelin-1	0,12	superoxide	Endothelin-1	MESH:D013481	24323(Tax:10116)	Chemical	Gene	increases|dobj|START_ENTITY increases|nsubj|END_ENTITY	Endothelin-1 increases vascular superoxide via endothelin -LRB- A -RRB- - NADPH oxidase pathway in low-renin hypertension .
14517226	0	superoxide	77,87	Endothelin-1	0,12	superoxide	Endothelin-1	MESH:D013481	24323(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Endothelin-1 stimulates arterial VCAM-1 expression via NADPH oxidase-derived superoxide in mineralocorticoid hypertension .
18539650	0	superoxide	83,93	Endothelin-1	0,12	superoxide	Endothelin-1	MESH:D013481	1906	Chemical	Gene	H|amod|START_ENTITY channels|nmod|H regulates|dobj|channels regulates|nsubj|END_ENTITY	Endothelin-1 regulates cardiac L-type calcium channels via NAD -LRB- P -RRB- H oxidase-derived superoxide .
20638037	0	superoxide	22,32	Endothelin-1	0,12	superoxide	Endothelin-1	MESH:D013481	24323(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	Endothelin-1 enhances superoxide and prostaglandin_E2 production of isolated diabetic_glomeruli .
22483692	0	superoxide	23,33	Endothelin-1	0,12	superoxide	Endothelin-1	MESH:D013481	1906	Chemical	Gene	START_ENTITY|nsubj|increases increases|amod|END_ENTITY	Endothelin-1 increases superoxide production in human coronary artery bypass grafts .
26211713	0	superoxide	79,89	Endothelin-1	0,12	superoxide	Endothelin-1	MESH:D013481	1906	Chemical	Gene	production|compound|START_ENTITY Role|nmod|production impairs|dep|Role impairs|amod|END_ENTITY	Endothelin-1 impairs coronary arteriolar dilation : Role of p38 kinase-mediated superoxide production from NADPH oxidase .
8825394	0	superoxide	51,61	Endothelin-1	0,12	superoxide	Endothelin-1	MESH:D013481	1906	Chemical	Gene	anion|amod|START_ENTITY effect|nmod|anion has|dobj|effect has|nsubj|END_ENTITY	Endothelin-1 has a priming effect on production of superoxide anion by alveolar macrophages : its possible correlation with bronchopulmonary_dysplasia .
14500673	0	superoxide	53,63	Eosinophil_major_basic_protein	0,30	superoxide	Eosinophil major basic protein	MESH:D013481	5553	Chemical	Gene	production|compound|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Eosinophil_major_basic_protein stimulates neutrophil superoxide production by a class IA phosphoinositide 3-kinase and protein kinase C-zeta-dependent pathway .
1382400	0	superoxide	116,126	G-CSF	107,112	superoxide	G-CSF	MESH:D013481	1440	Chemical	Gene	generation|amod|START_ENTITY END_ENTITY|nmod|generation	-LSB- Role of polymorphonuclear leukocytes -LRB- PMN -RRB- and active oxygen species in hyperthermia -- enhancing effect of G-CSF on superoxide generation from PMN -RSB- .
1706523	0	superoxide	33,43	GMP140	17,23	superoxide	GMP140	MESH:D013481	6403	Chemical	Gene	release|amod|START_ENTITY inhibits|dobj|release inhibits|nsubj|END_ENTITY	Adhesion protein GMP140 inhibits superoxide anion release by human neutrophils .
16814134	0	superoxide	26,36	Ghrelin	0,7	superoxide	Ghrelin	MESH:D013481	59301(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Ghrelin inhibits vascular superoxide production in spontaneously hypertensive rats .
11728811	0	superoxide	99,109	Granulocyte-macrophage_colony-stimulating_factor	0,48	superoxide	Granulocyte-macrophage colony-stimulating factor	MESH:D013481	1437	Chemical	Gene	anion|amod|START_ENTITY survival|nmod|anion ensures|dobj|survival ensures|nsubj|END_ENTITY	Granulocyte-macrophage_colony-stimulating_factor ensures macrophage survival and generation of the superoxide anion : a study using a monocytic-differentiated HL60 subline .
1310696	0	superoxide	24,34	Growth_hormone	0,14	superoxide	Growth hormone	MESH:D013481	2688	Chemical	Gene	START_ENTITY|nsubj|augments augments|amod|END_ENTITY	Growth_hormone augments superoxide anion secretion of human neutrophils by binding to the prolactin_receptor .
2153171	0	superoxide	14,24	IL-4	0,4	superoxide	IL-4	MESH:D013481	3565	Chemical	Gene	production|amod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	IL-4 inhibits superoxide production by human mononuclear phagocytes .
18788099	0	superoxide	10,20	Ins2	75,79	superoxide	Ins2	MESH:D013481	16334(Tax:10090)	Chemical	Gene	contributes|nsubj|START_ENTITY contributes|nmod|END_ENTITY	Increased superoxide contributes to enhancement of vascular contraction in Ins2 -LRB- Akita -RRB- diabetic mice , an autosomal dominant mutant model .
1651364	0	superoxide	26,36	Interferon-gamma	0,16	superoxide	Interferon-gamma	MESH:D013481	3458	Chemical	Gene	production|amod|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	Interferon-gamma enhances superoxide production by HL-60 cells stimulated with multiple agonists .
16820786	0	superoxide	26,36	Interferon-gamma	0,16	superoxide	Interferon-gamma	MESH:D013481	3458	Chemical	Gene	production|amod|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	Interferon-gamma enhances superoxide production in human mesangial cells via the JAK-STAT pathway .
12031983	0	superoxide	83,93	Interleukin-10	0,14	superoxide	Interleukin-10	MESH:D013481	16153(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY protects|parataxis|role protects|nsubj|END_ENTITY	Interleukin-10 protects nitric_oxide-dependent relaxation during diabetes : role of superoxide .
11342529	0	superoxide	29,39	Leptin	0,6	superoxide	Leptin	MESH:D013481	3952	Chemical	Gene	production|compound|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Leptin induces mitochondrial superoxide production and monocyte_chemoattractant_protein-1 expression in aortic endothelial cells by increasing fatty_acid oxidation via protein kinase A. Leptin , a circulating hormone secreted mainly from adipose tissues , is involved in the control of body weight .
11498285	0	superoxide	97,107	MMP-9	62,67	superoxide	MMP-9	MESH:D013481	81687(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY upregulates|nmod|production upregulates|dobj|gene gene|amod|92-kDa_type_IV_collagenase 92-kDa_type_IV_collagenase|dep|END_ENTITY	v-Ha-RaS oncogene upregulates the 92-kDa_type_IV_collagenase -LRB- MMP-9 -RRB- gene by increasing cellular superoxide production and activating NF-kappaB .
21777517	0	superoxide	70,80	MMP-9	33,38	superoxide	MMP-9	MESH:D013481	4318	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Suppression of TNF-alpha-induced MMP-9 expression by a cell-permeable superoxide dismutase in keratinocytes .
7988055	0	superoxide	99,109	N-acetyl-beta-glucosaminidase	23,52	superoxide	N-acetyl-beta-glucosaminidase	MESH:D013481	10724	Chemical	Gene	START_ENTITY|nsubj|changes changes|nmod|END_ENTITY	Early changes of serum N-acetyl-beta-glucosaminidase , tissue_plasminogen_activator and erythrocyte superoxide dismutase in relation to retinopathy_in_type_1_diabetes_mellitus .
3008321	0	superoxide	83,93	N-formyl-methionyl-leucyl-phenylalanine	105,144	superoxide	N-formyl-methionyl-leucyl-phenylalanine	MESH:D013481	2357	Chemical	Gene	Effect|nmod|START_ENTITY Effect|acl|induced induced|nmod|END_ENTITY	Effect of diclofenac_sodium , tolfenamic_acid and indomethacin on the production of superoxide induced by N-formyl-methionyl-leucyl-phenylalanine in normal human polymorphonuclear leukocytes .
27094494	0	superoxide	61,71	NADPH_oxidase1	33,47	superoxide	NADPH oxidase1	MESH:D013481	27035	Chemical	Gene	generation|amod|START_ENTITY END_ENTITY|nmod|generation	Peroxiredoxin_6 -LRB- Prdx6 -RRB- supports NADPH_oxidase1 -LRB- Nox1 -RRB- - based superoxide generation and cell migration .
23624625	0	superoxide	55,65	NADPH_oxidase_4	24,39	superoxide	NADPH oxidase 4	MESH:D013481	50490(Tax:10090)	Chemical	Gene	source|nmod|START_ENTITY source|nsubj|END_ENTITY	Mitochondrial-localized NADPH_oxidase_4 is a source of superoxide in angiotensin_II-stimulated neurons .
20053956	0	superoxide	53,63	NOX2	0,4	superoxide	NOX2	MESH:D013481	1536	Chemical	Gene	source|nmod|START_ENTITY source|nsubj|END_ENTITY	NOX2 is the primary source of angiotensin_II-induced superoxide in the macula densa .
17472580	0	superoxide	49,59	NOX_4	37,42	superoxide	NOX 4	MESH:D013481	50507	Chemical	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	Polyunsaturated_fatty_acids modulate NOX_4 anion superoxide production in human fibroblasts .
16084549	0	superoxide	84,94	NPY	131,134	superoxide	NPY	MESH:D013481	24604(Tax:10116)	Chemical	Gene	dismutase|compound|START_ENTITY dismutase|appos|END_ENTITY	Activations of c-fos/c-jun signaling are involved in the modulation of hypothalamic superoxide dismutase -LRB- SOD -RRB- and neuropeptide_Y -LRB- NPY -RRB- gene expression in amphetamine-mediated appetite suppression .
19005069	2	superoxide	367,377	Nox2	352,356	superoxide	Nox1	MESH:D013481	237038(Tax:10090)	Chemical	Gene	ion|amod|START_ENTITY generates|dobj|ion generates|nsubj|END_ENTITY	Microglia , the resident CNS macrophages , are prominent sources of ROS through expression of the phagocyte oxidase which catalytic subunit Nox2 generates superoxide ion -LRB- O2 -LRB- .
19837950	0	superoxide	38,48	Nox2	30,34	superoxide	Nox2	MESH:D013481	13058(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	Direct evidence of a role for Nox2 in superoxide production , reduced nitric_oxide bioavailability , and early atherosclerotic_plaque formation in ApoE - / - mice .
20708598	0	superoxide	20,30	Nox2	66,70	superoxide	Nox2	MESH:D013481	1536	Chemical	Gene	overproduction|amod|START_ENTITY overproduction|nmod|D-Loop D-Loop|dep|END_ENTITY	Characterization of superoxide overproduction by the D-Loop -LRB- Nox4 -RRB- - Nox2 cytochrome b -LRB- 558 -RRB- in phagocytes-Differential sensitivity to calcium and phosphorylation events .
22287576	0	superoxide	60,70	Nox2	21,25	superoxide	Nox2	MESH:D013481	13058(Tax:10090)	Chemical	Gene	recruitment|amod|START_ENTITY vascular|dobj|recruitment vascular|nsubj|increases increases|compound|END_ENTITY	Endothelial-specific Nox2 overexpression increases vascular superoxide and macrophage recruitment in ApoE / mice .
23955717	0	superoxide	44,54	Nox2	0,4	superoxide	Nox2	MESH:D013481	1536	Chemical	Gene	target|nmod|START_ENTITY END_ENTITY|nmod|target	Nox2 as a potential target of mitochondrial superoxide and its role in endothelial oxidative stress .
25056956	0	superoxide	117,127	Nox2	100,104	superoxide	Nox2	MESH:D013481	1536	Chemical	Gene	leading|xcomp|START_ENTITY END_ENTITY|acl|leading	Arachidonic_acid induces direct interaction of the p67 -LRB- phox -RRB- - Rac complex with the phagocyte oxidase Nox2 , leading to superoxide production .
12958025	0	superoxide	29,39	Rac	0,3	superoxide	Rac	MESH:D013481	207	Chemical	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Rac regulates cardiovascular superoxide through diverse molecular interactions : more than a binary GTP switch .
19923407	0	superoxide	27,37	Rac1	0,4	superoxide	Rac1	MESH:D013481	5879	Chemical	Gene	generation|compound|START_ENTITY mediates|dobj|generation mediates|nsubj|END_ENTITY	Rac1 mediates NaCl-induced superoxide generation in the thick ascending limb .
1320579	0	superoxide	21,31	SOD	43,46	superoxide	SOD	MESH:D013481	6647	Chemical	Gene	dismutase|amod|START_ENTITY dismutase|appos|END_ENTITY	Relationship between superoxide dismutase -LRB- SOD -RRB- and viral liver_diseases .
19799418	0	superoxide	63,73	SOD	117,120	superoxide	SOD	MESH:D013481	6647	Chemical	Gene	reacts|nmod|START_ENTITY reacts|nmod|rates rates|acl|approaching approaching|dobj|superoxide_dismutase superoxide_dismutase|appos|END_ENTITY	Vitamin_B -LRB- 12 -RRB- and redox homeostasis : cob -LRB- II -RRB- alamin reacts with superoxide at rates approaching superoxide_dismutase -LRB- SOD -RRB- .
21635891	1	superoxide	179,189	SOD	116,119	superoxide	SOD	MESH:D013481	39251(Tax:7227)	Chemical	Gene	removal|nmod|START_ENTITY regulate|dobj|removal one|acl:relcl|regulate one|nsubj|Superoxide_dismutase Superoxide_dismutase|appos|END_ENTITY	Superoxide_dismutase -LRB- SOD -RRB- is one of several major proteins that regulate removal of superoxide .
24078136	0	superoxide	144,154	SOD	166,169	superoxide	SOD	MESH:D013481	6647	Chemical	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Aggravation of diabetic_nephropathy in BCL-2 interacting cell death suppressor -LRB- BIS -RRB- - haploinsufficient mice together with impaired induction of superoxide dismutase -LRB- SOD -RRB- activity .
9178934	0	superoxide	149,159	SOD	72,75	superoxide	SOD	MESH:D013481	6647	Chemical	Gene	cytotoxicity|amod|START_ENTITY expression|nmod|cytotoxicity expression|nsubj|effect effect|nmod|transfection transfection|nmod|superoxide_dismutase superoxide_dismutase|appos|END_ENTITY	Protective effect of transfection with secretable superoxide_dismutase -LRB- SOD -RRB- -LRB- a signal sequence-SOD fusion protein coding cDNA -RRB- expression vector on superoxide anion-induced cytotoxicity in vitro .
11467048	0	superoxide	60,70	SOD-1	82,87	superoxide	SOD-1	MESH:D013481	20655(Tax:10090)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	GDNF is trophic for mouse motoneurons that express a mutant superoxide dismutase -LRB- SOD-1 -RRB- gene .
12235689	0	superoxide	81,91	SOD-1	103,108	superoxide	SOD-1	MESH:D013481	6647	Chemical	Gene	dismutase|amod|START_ENTITY dismutase|appos|END_ENTITY	-LSB- Activity of glutathione peroxidase -LRB- GSH-Px -RRB- , glutathione reductase -LRB- GSSG-R -RRB- and superoxide dismutase -LRB- SOD-1 -RRB- in single brain metastasis -RSB- .
4015619	0	superoxide	44,54	SOD-1	66,71	superoxide	SOD-1	MESH:D013481	20655(Tax:10090)	Chemical	Gene	dismutase|amod|START_ENTITY activities|amod|dismutase activities|dep|END_ENTITY	Tissue-specific developmental regulation of superoxide dismutase -LRB- SOD-1 and SOD-2 -RRB- activities in genetic strains of mice .
6860298	0	superoxide	20,30	SOD-1	42,47	superoxide	SOD-1	MESH:D013481	20655(Tax:10090)	Chemical	Gene	dismutase|amod|START_ENTITY activities|amod|dismutase activities|dep|END_ENTITY	Characterization of superoxide dismutase -LRB- SOD-1 and SOD-2 -RRB- activities in inbred mice : evidence for quantitative variability and possible nonallelic SOD-1 polymorphism .
9876869	0	superoxide	8,18	SOD-1	69,74	superoxide	SOD-1	MESH:D013481	20655(Tax:10090)	Chemical	Gene	dismutase|amod|START_ENTITY Role|nmod|dismutase Role|dep|study study|acl|using using|dobj|transgenic_mice transgenic_mice|compound|END_ENTITY	Role of superoxide dismutase in ischemic_brain_injury : a study using SOD-1 transgenic_mice .
19666610	0	superoxide	44,54	SOD-2	18,23	superoxide	SOD-2	MESH:D013481	20656(Tax:10090)	Chemical	Gene	reduces|dobj|START_ENTITY reduces|nsubj|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of SOD-2 reduces hippocampal superoxide and prevents memory_deficits in a mouse model of Alzheimer 's _ disease .
10721683	0	superoxide	78,88	SOD1	100,104	superoxide	SOD1	MESH:D013481	24786(Tax:10116)	Chemical	Gene	dismutase|compound|START_ENTITY dismutase|appos|END_ENTITY	Antidepressants upregulate messenger RNA levels of the neuroprotective enzyme superoxide dismutase -LRB- SOD1 -RRB- .
11585247	0	superoxide	21,31	SOD1	214,218	superoxide	SOD1	MESH:D013481	6647	Chemical	Gene	co-aggregates|amod|START_ENTITY Copper_chaperone|nmod|co-aggregates Copper_chaperone|dep|study study|nmod|familial_amyotrophic_lateral_sclerosis familial_amyotrophic_lateral_sclerosis|nmod|mutation mutation|compound|END_ENTITY	Copper_chaperone for superoxide dismutase co-aggregates with superoxide_dismutase_1 -LRB- SOD1 -RRB- in neuronal Lewy body-like hyaline inclusions : an immunohistochemical study on familial_amyotrophic_lateral_sclerosis with SOD1 gene mutation .
11585247	0	superoxide	21,31	SOD1	85,89	superoxide	SOD1	MESH:D013481	6647	Chemical	Gene	co-aggregates|amod|START_ENTITY co-aggregates|nmod|superoxide_dismutase_1 superoxide_dismutase_1|appos|END_ENTITY	Copper_chaperone for superoxide dismutase co-aggregates with superoxide_dismutase_1 -LRB- SOD1 -RRB- in neuronal Lewy body-like hyaline inclusions : an immunohistochemical study on familial_amyotrophic_lateral_sclerosis with SOD1 gene mutation .
15011248	0	superoxide	54,64	SOD1	83,87	superoxide	SOD1	MESH:D013481	20655(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|transgenic_mice transgenic_mice|appos|END_ENTITY	MRI detects early hindlimb muscle_atrophy in Gly93Ala superoxide dismutase-1 -LRB- G93A SOD1 -RRB- transgenic_mice , an animal model of familial_amyotrophic_lateral_sclerosis .
15350647	0	superoxide	4,14	SOD1	27,31	superoxide	SOD1	MESH:D013481	20655(Tax:10090)	Chemical	Gene	dismutase1|amod|START_ENTITY dismutase1|dep|END_ENTITY	The superoxide dismutase1 -LRB- SOD1 -RRB- G93A mutation does not promote neuronal_injury after focal brain_ischemia and optic nerve transection in mice .
1767591	0	superoxide	70,80	SOD1	92,96	superoxide	SOD1	MESH:D013481	853568(Tax:4932)	Chemical	Gene	dismutase|compound|START_ENTITY dismutase|appos|END_ENTITY	Cytochrome P450 lanosterol 14 alpha-demethylase -LRB- ERG11 -RRB- and manganese superoxide dismutase -LRB- SOD1 -RRB- are adjacent genes in Saccharomyces_cerevisiae .
18040680	0	superoxide	24,34	SOD1	45,49	superoxide	SOD1	MESH:D013481	853568(Tax:4932)	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Characterization of the superoxide dismutase SOD1 gene of Kluyveromyces marxianus L3 and improved production of SOD activity .
21945651	0	superoxide	77,87	SOD1	99,103	superoxide	SOD1	MESH:D013481	6647	Chemical	Gene	dismutase|compound|START_ENTITY dismutase|appos|END_ENTITY	Recombinant human erythropoietin reduces aggregation of mutant Cu/Zn-binding superoxide dismutase -LRB- SOD1 -RRB- in NSC-34 cells .
22416121	0	superoxide	25,35	SOD1	149,153	superoxide	SOD1	MESH:D013481	6647	Chemical	Gene	dismutase|amod|START_ENTITY form|nmod|dismutase found|nsubj|form found|dobj|mechanism mechanism|nmod|END_ENTITY	An over-oxidized form of superoxide dismutase found in sporadic amyotrophic_lateral_sclerosis with bulbar onset shares a toxic mechanism with mutant SOD1 .
24535002	0	superoxide	32,42	SOD1	121,125	superoxide	SOD1	MESH:D013481	6647	Chemical	Gene	anions|amod|START_ENTITY production|nmod|anions accompanied|nsubjpass|production accompanied|nmod|increase increase|nmod|concentration concentration|nummod|END_ENTITY	Selenite-mediated production of superoxide radical anions in A549 cancer cells is accompanied by a selective increase in SOD1 concentration , enhanced apoptosis and Se-Cu bonding .
26401327	0	superoxide	89,99	SOD1	122,126	superoxide	SOD1	MESH:D013481	403559(Tax:9615)	Chemical	Gene	associated|xcomp|START_ENTITY degenerative|acl|associated prevalence|nmod|degenerative study|nmod|prevalence dismutase|nsubj|study dismutase|dobj|mutation mutation|dep|END_ENTITY	A retrospective study of the prevalence of the canine degenerative myelopathy associated superoxide dismutase 1 mutation -LRB- SOD1 : c. 118G ___ > ___ A -RRB- in a referral population of German Shepherd dogs from the UK .
12040026	0	superoxide	79,89	SOD2	101,105	superoxide	SOD2	MESH:D013481	104973000	Chemical	Gene	dismutase|compound|START_ENTITY dismutase|appos|END_ENTITY	Identification of two novel ACTH-responsive genes encoding manganese-dependent superoxide dismutase -LRB- SOD2 -RRB- and the zinc finger protein TIS11b -LSB- tetradecanoyl_phorbol_acetate -LRB- TPA -RRB- - inducible sequence 11b -RSB- .
15752200	0	superoxide	98,108	SOD2	59,63	superoxide	SOD2	MESH:D013481	20656(Tax:10090)	Chemical	Gene	dismutases|amod|START_ENTITY roles|nmod|dismutases reveals|dobj|roles reveals|nsubj|Characterization Characterization|nmod|END_ENTITY	Characterization of Cryptococcus_neoformans variety gattii SOD2 reveals distinct roles of the two superoxide dismutases in fungal biology and virulence .
16123448	2	superoxide	383,393	SOD2	627,631	superoxide	Sod2	MESH:D013481	20656(Tax:10090)	Chemical	Gene	dismutase|compound|START_ENTITY known|nsubjpass|dismutase undertaken|advcl|known undertaken|xcomp|examine examine|nmod|levels levels|nmod|END_ENTITY	Because manganese superoxide dismutase -LRB- SOD2 -RRB- , localized in mitochondria , is known to be a key enzyme that protects the cells against oxidative stress , this study was undertaken to examine oxidation-induced apoptosis in cultured RPE cells with various levels of SOD2 .
19507253	0	superoxide	26,36	SOD2	48,52	superoxide	SOD2	MESH:D013481	6648	Chemical	Gene	dismutase|compound|START_ENTITY dismutase|appos|END_ENTITY	Upregulation of manganese superoxide dismutase -LRB- SOD2 -RRB- is a common pathway for neuroendocrine differentiation in prostate_cancer cells .
21212740	0	superoxide	47,57	SOD2	0,4	superoxide	SOD2	MESH:D013481	20656(Tax:10090)	Chemical	Gene	scavenger|nmod|START_ENTITY END_ENTITY|appos|scavenger	SOD2 , the principal scavenger of mitochondrial superoxide , is dispensable for embryogenesis and imaginal tissue development but essential for adult survival .
21241727	0	superoxide	32,42	SOD2	54,58	superoxide	SOD2	MESH:D013481	20656(Tax:10090)	Chemical	Gene	dismutase|compound|START_ENTITY dismutase|appos|END_ENTITY	The impact of partial manganese superoxide dismutase -LRB- SOD2 -RRB- - deficiency on mitochondrial oxidant stress , DNA fragmentation and liver_injury during acetaminophen hepatotoxicity .
21291351	0	superoxide	77,87	SOD2	99,103	superoxide	SOD2	MESH:D013481	20656(Tax:10090)	Chemical	Gene	cartilage|nmod|START_ENTITY exercise|nmod|cartilage Effect|nmod|exercise dismutase|nsubj|Effect dismutase|dobj|mice mice|appos|END_ENTITY	Effect of exercise on bone and articular cartilage in heterozygous manganese superoxide dismutase -LRB- SOD2 -RRB- deficient mice .
22302046	0	superoxide	22,32	SOD2	44,48	superoxide	SOD2	MESH:D013481	6648	Chemical	Gene	dismutase|compound|START_ENTITY dismutase|appos|END_ENTITY	Mitochondria-targeted superoxide dismutase -LRB- SOD2 -RRB- regulates radiation resistance and radiation stress response in HeLa cells .
22972774	0	superoxide	69,79	SOD2	91,95	superoxide	SOD2	MESH:D013481	6648	Chemical	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Association of copper-zinc_superoxide dismutase -LRB- SOD1 -RRB- and manganese superoxide dismutase -LRB- SOD2 -RRB- genes with nonsyndromic myelomeningocele .
23237540	0	superoxide	12,22	SOD2	34,38	superoxide	SOD2	MESH:D013481	20656(Tax:10090)	Chemical	Gene	dismutase|compound|START_ENTITY dismutase|appos|END_ENTITY	A manganese superoxide dismutase -LRB- SOD2 -RRB- - mediated adaptive response .
24819633	0	superoxide	10,20	SOD2	32,36	superoxide	SOD2	MESH:D013481	6648	Chemical	Gene	dismutase|compound|START_ENTITY dismutase|appos|END_ENTITY	Manganese superoxide dismutase -LRB- SOD2 -RRB- polymorphisms , plasma advanced oxidation protein products -LRB- AOPP -RRB- concentration and risk of kidney_complications in subjects with type 1 diabetes .
25829510	3	superoxide	495,505	SOD2	567,571	superoxide	SOD2	MESH:D013481	20656(Tax:10090)	Chemical	Gene	dismutase|compound|START_ENTITY generated|iobj|dismutase generated|dobj|2 2|dep|mouse mouse|acl|deleting deleting|dobj|exon exon|nmod|gene gene|compound|END_ENTITY	We therefore generated a novel neuron-specific superoxide dismutase 2 -LRB- SOD2 -RRB- - deficient mouse by deleting exon 3 of the SOD2 gene using CamKIIa promoter-driven Cre expression .
27019981	0	superoxide	54,64	SOD2	76,80	superoxide	SOD2	MESH:D013481	6648	Chemical	Gene	dismutase|compound|START_ENTITY dismutase|appos|END_ENTITY	Expression and polymorphism -LRB- rs4880 -RRB- of mitochondrial superoxide dismutase -LRB- SOD2 -RRB- and asparaginase induced hepatotoxicity in adult patients with acute_lymphoblastic_leukemia .
7959763	0	superoxide	14,24	SOD3	36,40	superoxide	SOD3	MESH:D013481	6649	Chemical	Gene	dismutase|compound|START_ENTITY dismutase|appos|END_ENTITY	Extracellular superoxide dismutase -LRB- SOD3 -RRB- : tissue-specific expression , genomic characterization , and computer-assisted sequence analysis of the human EC_SOD gene .
11527927	0	superoxide	34,44	Sod2	56,60	superoxide	Sod2	MESH:D013481	20656(Tax:10090)	Chemical	Gene	dismutase|compound|START_ENTITY dismutase|appos|END_ENTITY	Ocular pathology in mitochondrial superoxide dismutase -LRB- Sod2 -RRB- - deficient mice .
12586694	3	superoxide	474,484	Sod2	496,500	superoxide	SOD2	MESH:D013481	856399(Tax:4932)	Chemical	Gene	dismutase|compound|START_ENTITY dismutase|appos|END_ENTITY	Here we show that mitochondrial superoxide dismutase -LRB- Sod2 -RRB- is required for survival extension in yeast .
9576791	0	superoxide	41,51	Sod4	69,73	superoxide	Sod4	MESH:D013481	542722(Tax:4577)	Chemical	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Two structurally similar maize cytosolic superoxide dismutase genes , Sod4 and Sod4A , respond differentially to abscisic_acid and high osmoticum .
20553682	0	superoxide	9,19	Src	56,59	superoxide	Src	MESH:D013481	83805(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|kinase kinase|compound|END_ENTITY	Vascular superoxide production by endothelin-1 requires Src non-receptor protein tyrosine kinase and MAPK activation .
19602668	0	superoxide	27,37	Stanniocalcin-1	0,15	superoxide	Stanniocalcin-1	MESH:D013481	6781	Chemical	Gene	START_ENTITY|nsubj|suppresses suppresses|amod|END_ENTITY	Stanniocalcin-1 suppresses superoxide generation in macrophages through induction of mitochondrial UCP2 .
11490098	1	superoxide	156,166	TNF	208,211	superoxide	TNF	MESH:D013481	21926(Tax:10090)	Chemical	Gene	production|nmod|START_ENTITY Increase|nmod|production sufficient|nsubj|Increase sufficient|xcomp|mimic mimic|dobj|action action|nmod|END_ENTITY	Increase in the production of superoxide is not sufficient to mimic the action of TNF .
21246206	0	superoxide	98,108	TNF	8,11	superoxide	TNF	MESH:D013481	21926(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY results|dep|role results|compound|END_ENTITY	Central TNF inhibition results in attenuated neurohumoral excitation in heart_failure : a role for superoxide and nitric_oxide .
2372299	0	superoxide	62,72	TNF	27,30	superoxide	TNF	MESH:D013481	7124	Chemical	Gene	dismutase|amod|START_ENTITY END_ENTITY|dobj|dismutase	Induction of resistance to TNF cytotoxicity and mitochondrial superoxide dismutase on U-937 cells by 1,25-dihydroxyvitamin _ D3 .
8381598	0	superoxide	40,50	TNF	18,21	superoxide	TNF	MESH:D013481	24835(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	Effect of in vivo TNF administration on superoxide production and PKC activity of rat alveolar macrophages .
10440583	0	superoxide	12,22	TNF-alpha	34,43	superoxide	TNF-alpha	MESH:D013481	7124	Chemical	Gene	role|nmod|START_ENTITY role|amod|radical radical|nmod|activation activation|amod|END_ENTITY	The role of superoxide radical in TNF-alpha induced NF-kappaB activation .
10465100	0	superoxide	36,46	TNF-alpha	171,180	superoxide	TNF-alpha	MESH:D013481	21926(Tax:10090)	Chemical	Gene	dismutase|amod|START_ENTITY correction|nmod|dismutase plasmid/liposome|nsubj|correction plasmid/liposome|dep|therapy therapy|dep|modulation modulation|nmod|mRNA mRNA|nmod|END_ENTITY	Manganese -LSB- correction of Magnesium -RSB- superoxide dismutase -LRB- MnSOD -RRB- plasmid/liposome pulmonary radioprotective gene therapy : modulation of irradiation-induced mRNA for IL-I , TNF-alpha , and TGF-beta correlates with delay of organizing_alveolitis / fibrosis .
10666000	0	superoxide	178,188	TNF-alpha	145,154	superoxide	TNF-alpha	MESH:D013481	7124	Chemical	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	Tumor_necrosis_factor-alpha-mediated signal transduction in human neutrophils : involvement of sphingomyelin metabolites in the priming effect of TNF-alpha on the fMLP-stimulated superoxide production .
11313892	0	superoxide	9,19	TNF-alpha	126,135	superoxide	TNF-alpha	MESH:D013481	7124	Chemical	Gene	production|amod|START_ENTITY Elevated|dobj|production Elevated|nsubj|proliferation proliferation|appos|migration migration|nmod|END_ENTITY	Elevated superoxide production by active H-ras enhances human lung WI-38VA-13 cell proliferation , migration and resistance to TNF-alpha .
11589516	0	superoxide	22,32	TNF-alpha	88,97	superoxide	TNF-alpha	MESH:D013481	7124	Chemical	Gene	dismutase|compound|START_ENTITY suppresses|nsubj|dismutase suppresses|dobj|augmentation augmentation|nmod|production production|amod|END_ENTITY	Liposome-encapsulated superoxide dismutase suppresses liposome-mediated augmentation of TNF-alpha production from peripheral blood leucocytes .
19083398	5	superoxide	881,891	TNF-alpha	829,838	superoxide	TNF-alpha	MESH:D013481	24835(Tax:10116)	Chemical	Gene	activities|nmod|START_ENTITY dismutase|nsubj|activities alterations|dep|dismutase alterations|appos|concentrations concentrations|nmod|END_ENTITY	The pathologic alterations of lung tissues , the concentrations of TNF-alpha , NO , malonyldialdehyde , the activities of superoxide dismutase in plasma , and the expression of TNF-alpha in lungs were assessed on day 3 , 7 , 14 , and 28 after BLM instillation .
9310121	0	superoxide	14,24	TNF-alpha	92,101	superoxide	TNF-alpha	MESH:D013481	7124	Chemical	Gene	production|amod|START_ENTITY Inhibition|nmod|production Inhibition|acl|primed primed|nmod|END_ENTITY	Inhibition of superoxide production and chemotaxis by methotrexate in neutrophils primed by TNF-alpha or LPS .
9513905	0	superoxide	93,103	TNF-alpha	0,9	superoxide	TNF-alpha	MESH:D013481	24835(Tax:10116)	Chemical	Gene	generation|nmod|START_ENTITY increases|nmod|generation increases|nsubj|END_ENTITY	TNF-alpha increases albumin permeability of isolated rat glomeruli through the generation of superoxide .
22484311	0	superoxide	90,100	Tec	164,167	superoxide	Tec	MESH:D013481	7006	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	5-Hydroxy-7-methoxyflavone inhibits N-formyl-L-methionyl-L-leucyl-L-phenylalanine-induced superoxide anion production by specific modulate membrane localization of Tec with a PI3K independent mechanism in human neutrophils .
8394973	0	superoxide	43,53	Thyrotropin-releasing_hormone	0,29	superoxide	Thyrotropin-releasing hormone	MESH:D013481	100346454(Tax:9986)	Chemical	Gene	production|amod|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	Thyrotropin-releasing_hormone enhances the superoxide anion production of rabbit peritoneal macrophages stimulated with N-formyl-methionyl-leucyl-phenylalanine and opsonized zymosan .
17916951	0	superoxide	155,165	UCP-2	188,193	superoxide	UCP-2	MESH:D013481	7351	Chemical	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	Increased plasma manganese , partially reduced ascorbate , 1 and absence of mitochondrial oxidative stress in type 2 diabetes_mellitus : implications for the superoxide uncoupling_protein_2 -LRB- UCP-2 -RRB- pathway .
19602668	0	superoxide	27,37	UCP2	99,103	superoxide	UCP2	MESH:D013481	7351	Chemical	Gene	START_ENTITY|nmod|induction induction|nmod|END_ENTITY	Stanniocalcin-1 suppresses superoxide generation in macrophages through induction of mitochondrial UCP2 .
14517226	0	superoxide	77,87	VCAM-1	33,39	superoxide	VCAM-1	MESH:D013481	25361(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Endothelin-1 stimulates arterial VCAM-1 expression via NADPH oxidase-derived superoxide in mineralocorticoid hypertension .
11992625	0	superoxide	14,24	YC-1	45,49	superoxide	YC-1	MESH:D013481	24421(Tax:10116)	Chemical	Gene	generation|amod|START_ENTITY generation|nmod|END_ENTITY	Inhibition of superoxide anion generation by YC-1 in rat neutrophils through cyclic_GMP-dependent and - independent mechanisms .
10603428	0	superoxide	15,25	angiotensin_II	47,61	superoxide	angiotensin II	MESH:D013481	24179(Tax:10116)	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of superoxide in acute reaction of angiotensin_II in mesenteric microcirculation .
10801763	0	superoxide	34,44	angiotensin_II	69,83	superoxide	angiotensin II	MESH:D013481	183	Chemical	Gene	sources|nmod|START_ENTITY Investigation|nmod|sources Investigation|dep|production production|compound|END_ENTITY	Investigation into the sources of superoxide in human blood vessels : angiotensin_II increases superoxide production in human internal mammary arteries .
10801763	0	superoxide	94,104	angiotensin_II	69,83	superoxide	angiotensin II	MESH:D013481	183	Chemical	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	Investigation into the sources of superoxide in human blood vessels : angiotensin_II increases superoxide production in human internal mammary arteries .
11030714	0	superoxide	69,79	angiotensin_II	21,35	superoxide	angiotensin II	MESH:D013481	183	Chemical	Gene	formation|compound|START_ENTITY subtypes|nmod|formation subtypes|nsubj|role role|nmod|receptor receptor|amod|END_ENTITY	Differential role of angiotensin_II receptor subtypes on endothelial superoxide formation .
11132603	0	superoxide	70,80	angiotensin_II	116,130	superoxide	angiotensin II	MESH:D013481	24179(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY production|nmod|action action|nmod|END_ENTITY	Chronic inhibition of nitric_oxide synthesis in rats increases aortic superoxide anion production via the action of angiotensin_II .
11446714	0	superoxide	24,34	angiotensin_II	38,52	superoxide	angiotensin II	MESH:D013481	183	Chemical	Gene	generation|nmod|START_ENTITY generation|nmod|END_ENTITY	Increased generation of superoxide by angiotensin_II in smooth muscle cells from resistance arteries of hypertensive patients : role of phospholipase_D-dependent NAD -LRB- P -RRB- H oxidase-sensitive pathways .
12374897	0	superoxide	40,50	angiotensin_II	70,84	superoxide	angiotensin II	MESH:D013481	183	Chemical	Gene	anion|amod|START_ENTITY fluvastatin|nmod|anion effects|nmod|fluvastatin activated|nsubj|effects activated|nmod|END_ENTITY	Antioxidative effects of fluvastatin on superoxide anion activated by angiotensin_II in human aortic smooth muscle cells .
12663375	0	superoxide	68,78	angiotensin_II	93,107	superoxide	angiotensin II	MESH:D013481	183	Chemical	Gene	generation|amod|START_ENTITY role|nmod|generation phosphorylation|dep|role induces|dobj|phosphorylation induces|nmod|END_ENTITY	c-Src induces phosphorylation and translocation of p47phox : role in superoxide generation by angiotensin_II in human vascular smooth muscle cells .
12975388	0	superoxide	42,52	angiotensin_II	104,118	superoxide	angiotensin II	MESH:D013481	24179(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY linked|nsubjpass|production linked|nmod|upregulation upregulation|nmod|END_ENTITY	In salt-sensitive hypertension , increased superoxide production is linked to functional upregulation of angiotensin_II .
14597645	0	superoxide	8,18	angiotensin_II	54,68	superoxide	angiotensin II	MESH:D013481	183	Chemical	Gene	START_ENTITY|acl|modulating modulating|dobj|effects effects|nmod|END_ENTITY	Role of superoxide in modulating the renal effects of angiotensin_II .
15192025	0	superoxide	66,76	angiotensin_II	23,37	superoxide	angiotensin II	MESH:D013481	11606(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY involves|dobj|production involves|nsubj|Hypertension Hypertension|acl|caused caused|nmod|infusion infusion|amod|END_ENTITY	Hypertension caused by angiotensin_II infusion involves increased superoxide production in the central nervous system .
15761243	0	superoxide	26,36	angiotensin_II	71,85	superoxide	angiotensin II	MESH:D013481	183	Chemical	Gene	glucose|nmod|START_ENTITY Effect|nmod|glucose Effect|dep|role role|nmod|END_ENTITY	Effect of high glucose on superoxide in human mesangial cells : role of angiotensin_II .
15922319	0	superoxide	18,28	angiotensin_II	66,80	superoxide	angiotensin II	MESH:D013481	183	Chemical	Gene	production|amod|START_ENTITY H-dependent|dobj|production H-dependent|parataxis|role role|nmod|END_ENTITY	NAD -LRB- P -RRB- H-dependent superoxide production in platelets : the role of angiotensin_II and protein_kinase_C .
16093920	0	superoxide	55,65	angiotensin_II	80,94	superoxide	angiotensin II	MESH:D013481	24179(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY production|nmod|hypertension hypertension|amod|END_ENTITY	Vascular but not cardiac remodeling is associated with superoxide production in angiotensin_II hypertension .
16331108	0	superoxide	102,112	angiotensin_II	32,46	superoxide	angiotensin II	MESH:D013481	24179(Tax:10116)	Chemical	Gene	production|nmod|START_ENTITY mediated|nmod|production mediated|nsubjpass|effect effect|nmod|END_ENTITY	Acute pressor effect of central angiotensin_II is mediated by NAD -LRB- P -RRB- H-oxidase-dependent production of superoxide in the hypothalamic cardiovascular regulatory nuclei .
19558814	0	superoxide	25,35	angiotensin_II	144,158	superoxide	angiotensin II	MESH:D013481	24179(Tax:10116)	Chemical	Gene	anion|amod|START_ENTITY Effects|nmod|anion Effects|acl|induced induced|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Effects of clearance of superoxide anion by catechin on the expression of NO and eNOS and apoptosis in endothelial progenitor cells induced by angiotensin_II -RSB- .
20814019	0	superoxide	134,144	angiotensin_II	102,116	superoxide	angiotensin II	MESH:D013481	24179(Tax:10116)	Chemical	Gene	homeostasis|amod|START_ENTITY significance|nmod|homeostasis upregulation|dep|significance upregulation|nmod|brain-derived_neurotrophic_factor brain-derived_neurotrophic_factor|nmod|medulla medulla|nmod|END_ENTITY	Transcriptional upregulation of brain-derived_neurotrophic_factor in rostral ventrolateral medulla by angiotensin_II : significance in superoxide homeostasis and neural regulation of arterial pressure .
22308229	0	superoxide	140,150	angiotensin_II	9,23	superoxide	angiotensin II	MESH:D013481	24179(Tax:10116)	Chemical	Gene	involvement|nmod|START_ENTITY END_ENTITY|dep|involvement	Elevated angiotensin_II in rat nodose ganglia primes diabetes-blunted_arterial_baroreflex_sensitivity : involvement of NADPH oxidase-derived superoxide .
22532027	0	superoxide	23,33	c-Src	67,72	superoxide	c-Src	MESH:D013481	6714	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	NADPH oxidase-produced superoxide mediates EGFR transactivation by c-Src in arsenic_trioxide-stimulated human keratinocytes .
12609977	0	superoxide	87,97	cAMP-responsive_element-binding_protein	20,59	superoxide	cAMP-responsive element-binding protein	MESH:D013481	81646(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|END_ENTITY	Redox regulation of cAMP-responsive_element-binding_protein and induction of manganous superoxide dismutase in nerve growth factor-dependent cell survival .
8957234	0	superoxide	77,87	calcitonin_gene-related_peptide	22,53	superoxide	calcitonin gene-related peptide	MESH:D013481	796	Chemical	Gene	production|compound|START_ENTITY effects|nmod|production effects|nmod|END_ENTITY	Inhibitory effects of calcitonin_gene-related_peptide on substance-P-induced superoxide production in human neutrophils .
10381203	0	superoxide	10,20	catalase	32,40	superoxide	catalase	MESH:D013481	12359(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|amod|END_ENTITY	Effect of superoxide dismutase , catalase , chelating agents , and free radical scavengers on the toxicity of alloxan to isolated pancreatic islets in vitro .
12469627	0	superoxide	139,149	catalase	71,79	superoxide	catalase	MESH:D013481	847	Chemical	Gene	gene|amod|START_ENTITY D6S392|dobj|gene D6S392|nsubj|analysis analysis|nmod|connection connection|nmod|C1167T C1167T|nmod|gene gene|amod|END_ENTITY	-LSB- Associative analysis of the connection between mutation C1167T in the catalase gene and polymorphic marker D6S392 nearby the Mn-dependent superoxide dismutase gene with diabetic_microangiopathies -RSB- .
12679155	0	superoxide	2,12	catalase	36,44	superoxide	catalase	MESH:D013481	24248(Tax:10116)	Chemical	Gene	mimetic|amod|START_ENTITY mimetic|nmod|activity activity|amod|END_ENTITY	A superoxide dismutase mimetic with catalase activity -LRB- EUK-8 -RRB- reduces the organ injury in endotoxic_shock .
12811507	0	superoxide	30,40	catalase	20,28	superoxide	catalase	MESH:D013481	847	Chemical	Gene	START_ENTITY|nsubj|nitric_oxide nitric_oxide|appos|END_ENTITY	Serum nitric_oxide , catalase , superoxide dismutase , and malondialdehyde status in patients with ankylosing_spondylitis .
14644473	0	superoxide	17,27	catalase	39,47	superoxide	catalase	MESH:D013481	24248(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|peroxidase peroxidase|amod|END_ENTITY	NAD -LRB- P -RRB- H oxidase , superoxide dismutase , catalase , glutathione peroxidase and nitric_oxide synthase expression in subacute spinal_cord_injury .
1709221	0	superoxide	128,138	catalase	154,162	superoxide	catalase	MESH:D013481	100340891(Tax:9986)	Chemical	Gene	dismutase|amod|START_ENTITY dismutase|amod|END_ENTITY	Protection against postischemic myocardial_dysfunction in anesthetized rabbits with scavengers of oxygen-derived free radicals : superoxide dismutase plus catalase , N-2-mercaptopropionyl_glycine and captopril .
17288196	0	superoxide	15,25	catalase	37,45	superoxide	catalase	MESH:D013481	847	Chemical	Gene	dismutase|amod|START_ENTITY Activities|nmod|dismutase glutathione|nsubj|Activities glutathione|advmod|END_ENTITY	-LSB- Activities of superoxide dismutase , catalase , glutathione peroxidase and reductase in umbilical cord blood of newborns from mothers smoking during pregnancy -RSB- .
2386536	0	superoxide	27,37	catalase	67,75	superoxide	catalase	MESH:D013481	24248(Tax:10116)	Chemical	Gene	dismutase|amod|START_ENTITY Glutathione-S-transferase|amod|dismutase xanthine|nsubj|Glutathione-S-transferase xanthine|dobj|peroxidase peroxidase|amod|END_ENTITY	Glutathione-S-transferase , superoxide dismutase , xanthine oxidase , catalase , glutathione peroxidase and lipid peroxidation in the liver of exercised rats .
2460855	0	superoxide	11,21	catalase	37,45	superoxide	catalase	MESH:D013481	24248(Tax:10116)	Chemical	Gene	dismutase|compound|START_ENTITY dismutase|nmod|END_ENTITY	Parenteral superoxide dismutase plus catalase diminishes pancreatic edema in sodium_taurocholate-induced pancreatitis in the rat .
24866930	0	superoxide	50,60	catalase	72,80	superoxide	catalase	MESH:D013481	12359(Tax:10090)	Chemical	Gene	dismutase|amod|START_ENTITY activity|nmod|dismutase N-methyl-D-aspartic_acid|nmod|activity Effect|nmod|N-methyl-D-aspartic_acid glutathione|nsubj|Effect glutathione|advmod|END_ENTITY	Effect of N-methyl-D-aspartic_acid on activity of superoxide dismutase , catalase , glutathione peroxidase and reduced_glutathione level in selected organs of the mouse .
26368658	0	superoxide	32,42	catalase	54,62	superoxide	catalase	MESH:D013481	847	Chemical	Gene	dismutase|amod|START_ENTITY indicate|dobj|dismutase indicate|advmod|END_ENTITY	Physiological analyses indicate superoxide dismutase , catalase , and phytochelatins play important roles in Pb tolerance in Eremochloa ophiuroides .
26490662	0	superoxide	78,88	catalase	68,76	superoxide	catalase	MESH:D013481	847	Chemical	Gene	dismutase|amod|START_ENTITY dismutase|dep|END_ENTITY	In vitro effects of infrared A radiation on the synthesis of MMP-1 , catalase , superoxide dismutase and GADD45_alpha protein .
2904372	0	superoxide	96,106	catalase	86,94	superoxide	catalase	MESH:D013481	531682(Tax:9913)	Chemical	Gene	dismutase|amod|START_ENTITY dismutase|amod|END_ENTITY	Bovine non-pigmented and pigmented ciliary epithelial cells in culture : comparison of catalase , superoxide dismutase and glutathione peroxidase activities .
2909304	1	superoxide	64,74	catalase	90,98	superoxide	catalase	MESH:D013481	403474(Tax:9615)	Chemical	Gene	dismutase|amod|START_ENTITY dismutase|nmod|END_ENTITY	Effect of superoxide dismutase plus catalase , given at the time of reperfusion , on myocardial_infarct size , contractile function , coronary microvasculature , and regional myocardial blood flow .
3228770	0	superoxide	10,20	catalase	36,44	superoxide	catalase	MESH:D013481	100340891(Tax:9986)	Chemical	Gene	plus|amod|START_ENTITY Effect|nmod|plus END_ENTITY|nsubj|Effect	Effect of superoxide dismutase plus catalase on myocardial_infarct size in rabbits .
3361928	0	superoxide	91,101	catalase	117,125	superoxide	catalase	MESH:D013481	24248(Tax:10116)	Chemical	Gene	ischemia|nmod|START_ENTITY protection|nmod|ischemia Enhancement|nmod|protection dismutase|nsubj|Enhancement dismutase|dobj|END_ENTITY	Enhancement of crystalloid cardioplegic protection against global normothermic ischemia by superoxide dismutase plus catalase but not diltiazem in the isolated , working rat heart .
3595980	1	superoxide	84,94	catalase	74,82	superoxide	catalase	MESH:D013481	847	Chemical	Gene	dismutase|amod|START_ENTITY effect|amod|dismutase effect|nmod|END_ENTITY	Inhibitory effect of catalase , superoxide dismutase , serum proteins -LRB- ceruloplasmin , albumin , apotransferrin -RRB- and amino_acids .
3619138	0	superoxide	19,29	catalase	64,72	superoxide	catalase	MESH:D013481	847	Chemical	Gene	dismutase|amod|START_ENTITY dismutase|amod|END_ENTITY	-LSB- Concentrations of superoxide dismutase -LRB- copper and manganese -RRB- , catalase and glutathione peroxidase in red cells , platelets and plasma in patients with rheumatoid_polyarthritis -RSB- .
3807351	0	superoxide	10,20	catalase	36,44	superoxide	catalase	MESH:D013481	24248(Tax:10116)	Chemical	Gene	plus|amod|START_ENTITY Effect|nmod|plus END_ENTITY|nsubj|Effect	Effect of superoxide dismutase plus catalase on Ca2 + transport in ischemic and reperfused skeletal muscle .
6091498	0	superoxide	44,54	catalase	117,125	superoxide	catalase	MESH:D013481	847	Chemical	Gene	stains|amod|START_ENTITY Effects|nmod|stains Effects|nmod|END_ENTITY	Effects of molecular oxygen on detection of superoxide radical with nitroblue_tetrazolium and on activity stains for catalase .
6323471	0	superoxide	16,26	catalase	40,48	superoxide	catalase	MESH:D013481	531682(Tax:9913)	Chemical	Gene	reaction|nmod|START_ENTITY reaction|amod|radical radical|nmod|END_ENTITY	The reaction of superoxide radical with catalase .
6323471	1	superoxide	93,103	catalase	81,89	superoxide	catalase	MESH:D013481	531682(Tax:9913)	Chemical	Gene	radical|amod|START_ENTITY Mechanism|nmod|radical Mechanism|nmod|inhibition inhibition|nmod|END_ENTITY	Mechanism of the inhibition of catalase by superoxide radical .
7423531	0	superoxide	105,115	catalase	128,136	superoxide	catalase	MESH:D013481	24248(Tax:10116)	Chemical	Gene	dismutases|compound|START_ENTITY dismutases|appos|peroxidase peroxidase|amod|END_ENTITY	Adaptation to hyperoxia in the neonatal rat : kinetic parameters of the oxygen-mediated induction of lung superoxide dismutases , catalase and glutathione peroxidase .
7757201	0	superoxide	40,50	catalase	26,34	superoxide	catalase	MESH:D013481	531682(Tax:9913)	Chemical	Gene	radicals|amod|START_ENTITY END_ENTITY|nmod|radicals	Reactions of bovine liver catalase with superoxide radicals and hydrogen_peroxide .
8087206	0	superoxide	49,59	catalase	71,79	superoxide	catalase	MESH:D013481	24248(Tax:10116)	Chemical	Gene	dismutase|amod|START_ENTITY activity|nmod|dismutase temperature|nmod|activity Effect|nmod|temperature glutathione|nsubj|Effect glutathione|advmod|END_ENTITY	Effect of storage temperature on the activity of superoxide dismutase , catalase , glutathione peroxidase , glutathione_reductase and glutathione_S-transferase in rat liver and kidney homogenates .
8213440	0	superoxide	19,29	catalase	45,53	superoxide	catalase	MESH:D013481	101013655	Chemical	Gene	dismutase|amod|START_ENTITY dismutase|nmod|END_ENTITY	High - and low-dose superoxide dismutase plus catalase does not reduce myocardial_infarct size in a subhuman primate model .
8428478	0	superoxide	33,43	catalase	81,89	superoxide	catalase	MESH:D013481	397568(Tax:9823)	Chemical	Gene	dismutase|compound|START_ENTITY dismutase|appos|END_ENTITY	Use of polyethylene_glycol-bound superoxide dismutase , polyethylene_glycol-bound catalase , and nimodipine to prevent hypoxic ischemic injury_to_the_brain_of_newborn_pigs .
8862187	0	superoxide	18,28	catalase	40,48	superoxide	catalase	MESH:D013481	24248(Tax:10116)	Chemical	Gene	dismutase|amod|START_ENTITY activities|nmod|dismutase glutathione|nsubj|activities glutathione|advmod|END_ENTITY	The activities of superoxide dismutase , catalase , glutathione peroxidase and glutathione_reductase in erythrocytes of rats with experimental neoplastic_disease .
16531408	0	superoxide	62,72	cytochrome_b	29,41	superoxide	cytochrome b	MESH:D013481	4519	Chemical	Gene	generation|amod|START_ENTITY mediation|nmod|generation END_ENTITY|nmod|mediation	Direct and indirect roles of cytochrome_b in the mediation of superoxide generation and NO catabolism by mitochondrial succinate-cytochrome c reductase .
23418307	0	superoxide	80,90	cytochrome_b	4,16	superoxide	cytochrome b	MESH:D013481	4519	Chemical	Gene	production|amod|START_ENTITY enhances|dobj|production enhances|nsubj|causative causative|compound|END_ENTITY	The cytochrome_b p. 278Y > C mutation causative of a multisystem_disorder enhances superoxide production and alters supramolecular interactions of respiratory chain complexes .
24298890	0	superoxide	22,32	cytochrome_b	51,63	superoxide	cytochrome b	MESH:D013481	854583(Tax:4932)	Chemical	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Mechanism of enhanced superoxide production in the cytochrome_b -LRB- 6 -RRB- f complex of oxygenic photosynthesis .
8489236	0	superoxide	20,30	cytochrome_c	53,65	superoxide	cytochrome c	MESH:D013481	54205	Chemical	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Characterization of superoxide dismutase-insensitive cytochrome_c reductase activity in HL-60 cytosol as NADPH-cytochrome P450 reductase .
10443513	0	superoxide	42,52	endothelin-1	118,130	superoxide	endothelin-1	MESH:D013481	1906	Chemical	Gene	production|amod|START_ENTITY stimulation|nmod|production stimulation|dep|role role|nmod|END_ENTITY	Plasma-mediated stimulation of neutrophil superoxide anion production during coronary artery bypass grafting : role of endothelin-1 .
18436224	0	superoxide	28,38	endothelin-1	61,73	superoxide	endothelin-1	MESH:D013481	1906	Chemical	Gene	production|compound|START_ENTITY production|acl|induced induced|advcl|END_ENTITY	Quercetin inhibits vascular superoxide production induced by endothelin-1 : Role of NADPH oxidase , uncoupled eNOS and PKC .
7637895	0	superoxide	26,36	endothelin-1	120,132	superoxide	endothelin-1	MESH:D013481	24323(Tax:10116)	Chemical	Gene	dismutase|amod|START_ENTITY inhibitor|amod|dismutase Diethyldithiocarbamate|appos|inhibitor counteracts|nsubj|Diethyldithiocarbamate counteracts|dobj|maturation maturation|nmod|ischemic-like_lesions ischemic-like_lesions|acl|caused caused|nmod|injection injection|amod|END_ENTITY	Diethyldithiocarbamate , a superoxide dismutase inhibitor , counteracts the maturation of ischemic-like_lesions caused by endothelin-1 intrastriatal injection .
1654288	0	superoxide	12,22	erythropoietin	120,134	superoxide	erythropoietin	MESH:D013481	2056	Chemical	Gene	START_ENTITY|nmod|therapy therapy|compound|END_ENTITY	Whole blood superoxide anion generation and efficiency of some erythrocyte antioxidant systems during recombinant human erythropoietin therapy of uremic_anemia .
21945651	0	superoxide	77,87	erythropoietin	18,32	superoxide	erythropoietin	MESH:D013481	2056	Chemical	Gene	dismutase|compound|START_ENTITY aggregation|nmod|dismutase reduces|dobj|aggregation reduces|nsubj|END_ENTITY	Recombinant human erythropoietin reduces aggregation of mutant Cu/Zn-binding superoxide dismutase -LRB- SOD1 -RRB- in NSC-34 cells .
22528588	0	superoxide	140,150	erythropoietin	46,60	superoxide	erythropoietin	MESH:D013481	2056	Chemical	Gene	dismutase|compound|START_ENTITY levels|nmod|dismutase responsiveness|nmod|levels responsiveness|nsubj|influence influence|nmod|supplementation supplementation|nmod|END_ENTITY	The influence of vitamin_E supplementation on erythropoietin responsiveness in chronic hemodialysis patients with low levels of erythrocyte superoxide dismutase .
9350664	0	superoxide	42,52	erythropoietin	18,32	superoxide	erythropoietin	MESH:D013481	2056	Chemical	Gene	production|amod|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	Recombinant human erythropoietin enhances superoxide production by FMLP-stimulated polymorphonuclear leukocytes in hemodialysis patients .
27037373	0	superoxide	32,42	ferrochelatase	54,68	superoxide	ferrochelatase	MESH:D013481	790571(Tax:9913)	Chemical	Gene	role|nmod|START_ENTITY END_ENTITY|nsubj|role	Potential role of mitochondrial superoxide decreasing ferrochelatase _ heme in coronary artery soluble guanylate cyclase depletion by Angiotensin_II .
3218146	0	superoxide	86,96	glucose-6-phosphate_dehydrogenase	51,84	superoxide	glucose-6-phosphate dehydrogenase	MESH:D013481	2539	Chemical	Gene	START_ENTITY|nsubj|Changes Changes|amod|END_ENTITY	-LSB- Changes in glyceraldehydephosphate dehydrogenase , glucose-6-phosphate_dehydrogenase , superoxide dismutase , and catalase activity in erythrocytes depending upon the rate of glucose utilization -RSB- .
3355578	0	superoxide	83,93	glutathione-S-transferase	56,81	superoxide	glutathione-S-transferase	MESH:D013481	373156	Chemical	Gene	dismutase|amod|START_ENTITY dismutase|amod|END_ENTITY	The absence of adaptive changes in tissue activities of glutathione-S-transferase , superoxide dismutase and catalase following selenium and vitamin_E supplementation in subjects with low selenium status .
16085672	0	superoxide	40,50	gp91phox	70,78	superoxide	gp91phox	MESH:D013481	13058(Tax:10090)	Chemical	Gene	oxidase|amod|START_ENTITY oxidase|appos|END_ENTITY	Hypoxic pulmonary hypertension : role of superoxide and NADPH oxidase -LRB- gp91phox -RRB- .
12028049	0	superoxide	178,188	granulocyte-macrophage_colony-stimulating_factor	209,257	superoxide	granulocyte-macrophage colony-stimulating factor	MESH:D013481	1437	Chemical	Gene	production|amod|START_ENTITY N-formyl_peptide|nmod|production shown|nmod|N-formyl_peptide shown|nmod|END_ENTITY	Differentiation of PLB-985 myeloid cells into mature neutrophils , shown by degranulation of terminally differentiated compartments in response to N-formyl_peptide and priming of superoxide anion production by granulocyte-macrophage_colony-stimulating_factor .
12731668	0	superoxide	35,45	granulocyte-macrophage_colony-stimulating_factor	103,151	superoxide	granulocyte-macrophage colony-stimulating factor	MESH:D013481	1437	Chemical	Gene	release|amod|START_ENTITY inhibit|dobj|release inhibit|nmod|neutrophils neutrophils|acl|stimulated stimulated|nmod|END_ENTITY	Serine_protease inhibitors inhibit superoxide release and adherence in human neutrophils stimulated by granulocyte-macrophage_colony-stimulating_factor and tumor_necrosis_factor-alpha .
1312371	0	superoxide	182,192	granulocyte-macrophage_colony-stimulating_factor	72,120	superoxide	granulocyte-macrophage colony-stimulating factor	MESH:D013481	1437	Chemical	Gene	release|amod|START_ENTITY enhance|dobj|release enhance|nsubj|priming priming|nmod|monocytes monocytes|nmod|factors factors|dep|END_ENTITY	Rapid priming of human monocytes by human hematopoietic growth factors : granulocyte-macrophage_colony-stimulating_factor -LRB- CSF -RRB- , macrophage-CSF , and interleukin-3 selectively enhance superoxide release triggered by receptor-mediated agonists .
1365032	0	superoxide	78,88	granulocyte-macrophage_colony-stimulating_factor	18,66	superoxide	granulocyte-macrophage colony-stimulating factor	MESH:D013481	1437	Chemical	Gene	START_ENTITY|nsubj|stimulates stimulates|compound|END_ENTITY	Recombinant human granulocyte-macrophage_colony-stimulating_factor stimulates superoxide anion and hydrogen_peroxide production in human neutrophils .
2540792	0	superoxide	15,25	granulocyte-macrophage_colony-stimulating_factor	90,138	superoxide	granulocyte-macrophage colony-stimulating factor	MESH:D013481	1437	Chemical	Gene	anion|amod|START_ENTITY Enhancement|nmod|anion release|nsubj|Enhancement release|nmod|granulocytes granulocytes|acl|harvested harvested|nmod|patients patients|acl|receiving receiving|dobj|END_ENTITY	Enhancement of superoxide anion release by granulocytes harvested from patients receiving granulocyte-macrophage_colony-stimulating_factor .
2541141	0	superoxide	232,242	granulocyte-macrophage_colony-stimulating_factor	29,77	superoxide	granulocyte-macrophage colony-stimulating factor	MESH:D013481	1437	Chemical	Gene	production|amod|START_ENTITY relationship|nmod|production Effects|dep|relationship Effects|nmod|END_ENTITY	Effects of recombinant human granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSFrh -RRB- on transmembrane electrical potentials in granulocytes : relationship between enhancement of ligand-mediated depolarization and augmentation of superoxide anion -LRB- O2 - -RRB- production .
2545809	0	superoxide	62,72	granulocyte-macrophage_colony-stimulating_factor	10,58	superoxide	granulocyte-macrophage colony-stimulating factor	MESH:D013481	1437	Chemical	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	Effect of granulocyte-macrophage_colony-stimulating_factor on superoxide production in cytoplasts and intact human neutrophils : role of protein kinase and G-proteins .
7594500	0	superoxide	102,112	granulocyte-macrophage_colony-stimulating_factor	24,72	superoxide	granulocyte-macrophage colony-stimulating factor	MESH:D013481	1437	Chemical	Gene	generation|amod|START_ENTITY effects|nmod|generation effects|nmod|END_ENTITY	Differential effects of granulocyte-macrophage_colony-stimulating_factor on eosinophil and neutrophil superoxide anion generation .
3034272	0	superoxide	65,75	granulocyte_colony-stimulating_factor	18,55	superoxide	granulocyte colony-stimulating factor	MESH:D013481	1440	Chemical	Gene	release|amod|START_ENTITY enhances|dobj|release enhances|nsubj|END_ENTITY	Recombinant human granulocyte_colony-stimulating_factor enhances superoxide release in human granulocytes stimulated by the chemotactic peptide .
7535420	0	superoxide	34,44	granulocyte_colony-stimulating_factor	193,230	superoxide	granulocyte colony-stimulating factor	MESH:D013481	1440	Chemical	Gene	generation|amod|START_ENTITY Chronic_neutropenia|nmod|generation Chronic_neutropenia|dep|enhancement enhancement|nmod|capacity capacity|nmod|treatment treatment|nmod|END_ENTITY	Chronic_neutropenia and defect in superoxide generation of granulocytes in two patients : enhancement of bactericidal capacity and respiratory burst activity by treatment with recombinant human granulocyte_colony-stimulating_factor .
7689123	0	superoxide	71,81	granulocyte_colony-stimulating_factor	30,67	superoxide	granulocyte colony-stimulating factor	MESH:D013481	1440	Chemical	Gene	production|amod|START_ENTITY Effects|nmod|production Effects|nmod|END_ENTITY	-LSB- Effects of recombinant human granulocyte_colony-stimulating_factor on superoxide production by neutrophil in cancer patients receiving chemotherapy -RSB- .
8647914	0	superoxide	22,32	granulocyte_colony-stimulating_factor	87,124	superoxide	granulocyte colony-stimulating factor	MESH:D013481	1440	Chemical	Gene	production|amod|START_ENTITY inhibits|dobj|production inhibits|nmod|neutrophils neutrophils|acl|activated activated|nmod|END_ENTITY	Methotrexate inhibits superoxide production and chemotaxis in neutrophils activated by granulocyte_colony-stimulating_factor .
8835629	0	superoxide	143,153	granulocyte_colony-stimulating_factor	71,108	superoxide	granulocyte colony-stimulating factor	MESH:D013481	1440	Chemical	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	Glycosylation improves the priming effect exerted by recombinant human granulocyte_colony-stimulating_factor -LRB- lenograstim -RRB- on human neutrophil superoxide production .
10942521	0	superoxide	56,66	heme_oxygenase-1	8,24	superoxide	heme oxygenase-1	MESH:D013481	24451(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of heme_oxygenase-1 in the regulation of manganese superoxide dismutase gene expression in oxidatively-challenged astroglia .
8394173	0	superoxide	72,82	interferon-gamma	22,38	superoxide	interferon-gamma	MESH:D013481	3458	Chemical	Gene	production|amod|START_ENTITY effect|nmod|production effect|nmod|END_ENTITY	Synergistic effect of interferon-gamma and phorbol_myristate_acetate on superoxide production by human monocytes .
8641336	0	superoxide	15,25	interleukin-10	46,60	superoxide	interleukin-10	MESH:D013481	3586	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Suppression of superoxide anion production by interleukin-10 is accompanied by a downregulation of the genes for subunit proteins of NADPH oxidase .
1324288	0	superoxide	41,51	interleukin-4	24,37	superoxide	interleukin-4	MESH:D013481	3565	Chemical	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	Differential effects of interleukin-4 on superoxide anion production by human alveolar macrophages stimulated with lipopolysaccharide and interferon-gamma .
26998026	0	superoxide	25,35	interleukin-6	10,23	superoxide	interleukin-6	MESH:D013481	24498(Tax:10116)	Chemical	Gene	dismutase|amod|START_ENTITY dismutase|amod|END_ENTITY	Levels of interleukin-6 , superoxide dismutase and malondialdehyde in the lung tissue of a rat model of hypoxia-induced acute_pulmonary_edema .
23932941	0	superoxide	39,49	leptin	29,35	superoxide	leptin	MESH:D013481	100136133(Tax:8022)	Chemical	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	Effects of recombinant trout leptin in superoxide production and NF-kB/MAPK phosphorylation in blood leukocytes .
11368132	0	superoxide	45,55	myeloperoxidase	8,23	superoxide	myeloperoxidase	MESH:D013481	4353	Chemical	Gene	inhibition|compound|START_ENTITY END_ENTITY|dobj|inhibition	Induced myeloperoxidase activity and related superoxide inhibition during hormone replacement therapy .
3008848	0	superoxide	4,14	myeloperoxidase	37,52	superoxide	myeloperoxidase	MESH:D013481	4353	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	The superoxide dismutase activity of myeloperoxidase ; formation of compound III .
1280257	0	superoxide	14,24	nitric_oxide_synthase	43,64	superoxide	nitric oxide synthase	MESH:D013481	4843	Chemical	Gene	Generation|nmod|START_ENTITY END_ENTITY|nsubj|Generation	Generation of superoxide by purified brain nitric_oxide_synthase .
15748708	0	superoxide	66,76	nitric_oxide_synthase	30,51	superoxide	nitric oxide synthase	MESH:D013481	4842	Chemical	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	L-arginine regulates neuronal nitric_oxide_synthase production of superoxide and hydrogen_peroxide .
15852033	0	superoxide	22,32	nitric_oxide_synthase	139,160	superoxide	nitric oxide synthase	MESH:D013481	396859(Tax:9823)	Chemical	Gene	formation|amod|START_ENTITY augments|dobj|formation augments|nmod|effects effects|nmod|expression expression|nmod|oxidase oxidase|amod|END_ENTITY	Prednisolone augments superoxide formation in porcine pulmonary artery endothelial cells through differential effects on the expression of nitric_oxide_synthase and NADPH oxidase .
17138723	0	superoxide	80,90	nitric_oxide_synthase	112,133	superoxide	nitric oxide synthase	MESH:D013481	18125(Tax:10090)	Chemical	Gene	anion|amod|START_ENTITY anion|acl|generated generated|nmod|END_ENTITY	High salt intake reduces endothelium-dependent dilation of mouse arterioles via superoxide anion generated from nitric_oxide_synthase .
19802465	0	superoxide	26,36	nitric_oxide_synthase	51,72	superoxide	nitric oxide synthase	MESH:D013481	18125(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY reduce|dobj|production reduce|nmod|END_ENTITY	Purine nucleotides reduce superoxide production by nitric_oxide_synthase in a murine sepsis model .
7513691	0	superoxide	38,48	nitric_oxide_synthase	67,88	superoxide	nitric oxide synthase	MESH:D013481	4843	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Glutamate receptors induce a burst of superoxide via activation of nitric_oxide_synthase in arginine-depleted neurons .
9268712	0	superoxide	30,40	nitric_oxide_synthase	96,117	superoxide	nitric oxide synthase	MESH:D013481	4846	Chemical	Gene	generation|amod|START_ENTITY regulates|dobj|generation regulates|nmod|END_ENTITY	Tetrahydrobiopterin regulates superoxide and nitric_oxide generation by recombinant endothelial nitric_oxide_synthase .
10728373	0	superoxide	35,45	nuclear_factor-kappa_B	74,96	superoxide	nuclear factor-kappa B	MESH:D013481	4790	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Involvement of protein_kinase_C in superoxide anion-induced activation of nuclear_factor-kappa_B in human endothelial cells .
17087735	0	superoxide	41,51	p22phox	15,22	superoxide	p22phox	MESH:D013481	1535	Chemical	Gene	generation|amod|START_ENTITY END_ENTITY|nmod|generation	Degradation of p22phox and inhibition of superoxide generation by Ehrlichia chaffeensis in human monocytes .
26211713	0	superoxide	79,89	p38	59,62	superoxide	p38	MESH:D013481	1432	Chemical	Gene	production|compound|START_ENTITY production|amod|END_ENTITY	Endothelin-1 impairs coronary arteriolar dilation : Role of p38 kinase-mediated superoxide production from NADPH oxidase .
10706597	0	superoxide	42,52	p47phox	27,34	superoxide	p47phox	MESH:D013481	653361	Chemical	Gene	START_ENTITY|nsubj|knockout knockout|nmod|blocks blocks|amod|END_ENTITY	In vitro knockout of human p47phox blocks superoxide anion production and LDL oxidation by activated human monocytes .
11156938	0	superoxide	35,45	p47phox	23,30	superoxide	p47phox	MESH:D013481	17969(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	Genetic requirement of p47phox for superoxide production by murine microglia .
12657628	0	superoxide	51,61	p47phox	23,30	superoxide	p47phox	MESH:D013481	17969(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|homologous homologous|nmod|support support|amod|END_ENTITY	Proteins homologous to p47phox and p67phox support superoxide production by NAD -LRB- P -RRB- H oxidase 1 in colon epithelial cells .
12663375	0	superoxide	68,78	p47phox	51,58	superoxide	p47phox	MESH:D013481	653361	Chemical	Gene	generation|amod|START_ENTITY role|nmod|generation phosphorylation|dep|role phosphorylation|nmod|END_ENTITY	c-Src induces phosphorylation and translocation of p47phox : role in superoxide generation by angiotensin_II in human vascular smooth muscle cells .
15698597	0	superoxide	49,59	p47phox	92,99	superoxide	p47phox	MESH:D013481	653361	Chemical	Gene	generation|compound|START_ENTITY generation|nmod|END_ENTITY	Effect of sulfur amino_acids on stimulus-induced superoxide generation and translocation of p47phox and p67phox to cell membrane in human neutrophils and the scavenging of free radical .
17548354	0	superoxide	158,168	p47phox	102,109	superoxide	p47phox	MESH:D013481	653361	Chemical	Gene	production|compound|START_ENTITY elicit|dobj|production elicit|nsubj|components components|nummod|END_ENTITY	Tripartite chimeras comprising functional domains derived from the cytosolic NADPH oxidase components p47phox , p67phox , and Rac1 elicit activator-independent superoxide production by phagocyte membranes : an essential role for anionic membrane phospholipids .
2170384	0	superoxide	66,76	p47phox	111,118	superoxide	p47phox	MESH:D013481	653361	Chemical	Gene	generation|amod|START_ENTITY generation|nmod|END_ENTITY	Diradylglycerol synergizes with an anionic amphiphile to activate superoxide generation and phosphorylation of p47phox in a cell-free system from human neutrophils .
17548354	0	superoxide	158,168	p67phox	111,118	superoxide	p67phox	MESH:D013481	4688	Chemical	Gene	production|compound|START_ENTITY elicit|dobj|production elicit|nsubj|components components|nummod|END_ENTITY	Tripartite chimeras comprising functional domains derived from the cytosolic NADPH oxidase components p47phox , p67phox , and Rac1 elicit activator-independent superoxide production by phagocyte membranes : an essential role for anionic membrane phospholipids .
11732329	0	superoxide	40,50	peroxidase	22,32	superoxide	peroxidase	MESH:D013481	543313(Tax:4565)	Chemical	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	Role of extracellular peroxidase in the superoxide production by wheat root cells .
12455380	0	superoxide	39,49	peroxidase	14,24	superoxide	peroxidase	MESH:D013481	543313(Tax:4565)	Chemical	Gene	anion|amod|START_ENTITY generator|nmod|anion END_ENTITY|dep|generator	-LSB- Cell surface peroxidase -- generator of superoxide anion in wheat root cells under wound stress -RSB- .
15839210	0	superoxide	42,52	peroxidase	64,74	superoxide	peroxidase	MESH:D013481	542029(Tax:4577)	Chemical	Gene	dismutase|amod|START_ENTITY gamma-aminobutyric_acid|nmod|dismutase response|amod|gamma-aminobutyric_acid response|amod|END_ENTITY	-LSB- The effect of gamma-aminobutyric_acid in superoxide dismutase , peroxidase and catalase activity response to salt stress in maize seedling -RSB- .
19747097	0	superoxide	31,41	peroxidase	70,80	superoxide	peroxidase	MESH:D013481	543313(Tax:4565)	Chemical	Gene	production|amod|START_ENTITY phenols|nmod|production phenols|nmod|END_ENTITY	Effect of exogenous phenols on superoxide production by extracellular peroxidase from wheat seedling roots .
26417938	0	superoxide	44,54	peroxidase	76,86	superoxide	peroxidase	MESH:D013481	547504(Tax:3847)	Chemical	Gene	generation|nmod|START_ENTITY catalyzed|nsubj|generation catalyzed|nmod|END_ENTITY	Hydrogen_peroxide-independent generation of superoxide catalyzed by soybean peroxidase in response to ferrous ion .
22984687	0	superoxide	102,112	peroxisome_proliferator-activated_receptor	48,90	superoxide	peroxisome proliferator-activated receptor	MESH:D013481	5465	Chemical	Gene	induction|amod|START_ENTITY induction|amod|END_ENTITY	Fenofibrate decreases radiation sensitivity via peroxisome_proliferator-activated_receptor a-mediated superoxide dismutase induction in HeLa cells .
11834706	0	superoxide	74,84	phox	48,52	superoxide	phox	MESH:D013481	17304(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	Essential role of the NADPH oxidase subunit p47 -LRB- phox -RRB- in endothelial cell superoxide production in response to phorbol_ester and tumor_necrosis_factor-alpha .
20493251	0	superoxide	101,111	superoxide_dismutase_1	18,40	superoxide	superoxide dismutase 1	MESH:D013481	6647	Chemical	Gene	attenuates|nmod|START_ENTITY attenuates|nsubj|END_ENTITY	Pluronic-modified superoxide_dismutase_1 attenuates angiotensin_II-induced increase in intracellular superoxide in neurons .
16081273	0	superoxide	44,54	superoxide_dismutase_3	6,28	superoxide	superoxide dismutase 3	MESH:D013481	25352(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Serum superoxide_dismutase_3 -LRB- extracellular superoxide dismutase -RRB- activity is a sensitive indicator of Cu status in rats .
11068877	0	superoxide	22,32	transferrin	41,52	superoxide	transferrin	MESH:D013481	7018	Chemical	Gene	flux|compound|START_ENTITY flux|nmod|END_ENTITY	Effect of a prolonged superoxide flux on transferrin and ferritin .
1846518	0	superoxide	66,76	transferrin	26,37	superoxide	transferrin	MESH:D013481	7018	Chemical	Gene	anion|compound|START_ENTITY END_ENTITY|nmod|anion	Ferrous iron release from transferrin by human neutrophil-derived superoxide anion : effect of pH and iron saturation .
6092375	0	superoxide	94,104	transferrin	26,37	superoxide	transferrin	MESH:D013481	7018	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of human serum transferrin and milk lactoferrin on hydroxyl radical formation from superoxide and hydrogen_peroxide .
14752097	0	superoxide	203,213	transferrin_receptor	91,111	superoxide	transferrin receptor	MESH:D013481	7037	Chemical	Gene	depletion|nmod|START_ENTITY depletion|compound|END_ENTITY	1-Methyl-4-phenylpyridinium-induced apoptosis in cerebellar granule neurons is mediated by transferrin_receptor iron-dependent depletion of tetrahydrobiopterin and neuronal_nitric-oxide_synthase-derived superoxide .
1334475	0	superoxide	113,123	tumor_necrosis_factor-alpha	24,51	superoxide	tumor necrosis factor-alpha	MESH:D013481	7124	Chemical	Gene	generation|amod|START_ENTITY END_ENTITY|nmod|generation	Augmentative effects of tumor_necrosis_factor-alpha -LRB- human , natural type -RRB- on polymorphonuclear leukocyte-derived superoxide generation induced by various stimulants .
2168825	0	superoxide	57,67	tumor_necrosis_factor-alpha	26,53	superoxide	tumor necrosis factor-alpha	MESH:D013481	7124	Chemical	Gene	production|amod|START_ENTITY effect|nmod|production effect|nmod|END_ENTITY	The effect of recombinant tumor_necrosis_factor-alpha on superoxide and metalloproteinase production by synovial cells and chondrocytes .
17916951	0	superoxide	155,165	uncoupling_protein_2	166,186	superoxide	uncoupling protein 2	MESH:D013481	7351	Chemical	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	Increased plasma manganese , partially reduced ascorbate , 1 and absence of mitochondrial oxidative stress in type 2 diabetes_mellitus : implications for the superoxide uncoupling_protein_2 -LRB- UCP-2 -RRB- pathway .
25243829	0	superoxide	36,46	xanthine_dehydrogenase	63,85	superoxide	xanthine dehydrogenase	MESH:D013481	396025(Tax:9031)	Chemical	Gene	generation|amod|START_ENTITY generation|nmod|END_ENTITY	Measurement and characterization of superoxide generation from xanthine_dehydrogenase : a redox-regulated pathway of radical generation in ischemic tissues .
23105333	0	superoxide	104,114	xanthine_oxidase	86,102	superoxide	xanthine oxidase	MESH:D013481	22436(Tax:10090)	Chemical	Gene	dismutase|amod|START_ENTITY dismutase|amod|END_ENTITY	Studies on the effect of monosodium_glutamate -LRB- MSG -RRB- administration on the activity of xanthine_oxidase , superoxide dismutase and catalase in hepatic tissue of adult male mice .
8419075	0	suramin	21,28	CD4	14,17	suramin	CD4	MESH:D013498	920	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|END_ENTITY	Modulation of CD4 by suramin .
18374478	0	suramin	138,145	Lysyl_oxidase	0,13	suramin	Lysyl oxidase	MESH:D013498	4015	Chemical	Gene	upregulated|nmod|START_ENTITY upregulated|nsubjpass|END_ENTITY	Lysyl_oxidase -LRB- LOX -RRB- mRNA expression and genes of the differentiated osteoblastic phenotype are upregulated in human osteosarcoma cells by suramin .
21108244	0	suramin	61,68	TGF-b1	72,78	suramin	TGF-b1	MESH:D013498	21803(Tax:10090)	Chemical	Gene	START_ENTITY|appos|blocker blocker|compound|END_ENTITY	Prevention of muscle fibrosis and myonecrosis in mdx mice by suramin , a TGF-b1 blocker .
10449196	0	suramin	108,115	TNF-alpha	54,63	suramin	TNF-alpha	MESH:D013498	7124	Chemical	Gene	receptor|nmod|START_ENTITY receptor|amod|END_ENTITY	Inhibition of tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- / TNF-alpha receptor binding by structural analogues of suramin .
15840333	0	suramin	27,34	bFGF	38,42	suramin	bFGF	MESH:D013498	2247	Chemical	Gene	effects|nmod|START_ENTITY -LSB-|dobj|effects -LSB-|nmod|END_ENTITY	-LSB- The inhibiting effects of suramin on bFGF induced proliferation of cultured human RPE cells -RSB- .
10669049	0	suramin	31,38	chymase	20,27	suramin	chymase	MESH:D013498	1215	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of human chymase by suramin .
8914844	0	suramin	60,67	folylpolyglutamate_synthetase	27,56	suramin	folylpolyglutamate synthetase	MESH:D013498	2356	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Potent inhibition of human folylpolyglutamate_synthetase by suramin .
7666462	0	suramin	55,62	transferrin	12,23	suramin	transferrin	MESH:D013498	7018	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nmod|effect	Reversal by transferrin of growth-inhibitory effect of suramin on hormone-refractory human prostate_cancer cells .
7752260	0	suramin	59,66	transferrin	16,27	suramin	transferrin	MESH:D013498	7018	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nmod|effect	Re : Reversal by transferrin of growth-inhibitory effect of suramin on hormone-refractory human prostate_cancer cells .
1325955	0	suramin	21,28	tumor_necrosis_factor_alpha	75,102	suramin	tumor necrosis factor alpha	MESH:D013498	7124	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|binding binding|nmod|END_ENTITY	Inhibitory effect of suramin on receptor binding and cytotoxic activity of tumor_necrosis_factor_alpha .
2362291	0	suramin	24,31	tumor_necrosis_factor_alpha	37,64	suramin	tumor necrosis factor alpha	MESH:D013498	7124	Chemical	Gene	activity|nmod|START_ENTITY activity|nmod|END_ENTITY	Synergistic activity of suramin with tumor_necrosis_factor_alpha and doxorubicin on human prostate_cancer cell lines .
2695900	0	synenkephalin	14,27	enkephalin	43,53	synenkephalin	enkephalin	MESH:C036693	29237(Tax:10116)	Chemical	Gene	Comparison|nmod|START_ENTITY END_ENTITY|nsubj|Comparison	Comparison of synenkephalin and methionine enkephalin immunocytochemistry in rat brain .
11231277	0	synovium	39,47	ADAMTS-5	27,35	synovium	ADAMTS-5	null	11096	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression and activity of ADAMTS-5 in synovium .
2786954	0	synovium	27,35	catabolin	14,23	synovium	catabolin	null	3553	Chemical	Gene	Production|nmod|START_ENTITY Production|nmod|END_ENTITY	Production of catabolin by synovium from an experimental model of osteoarthritis .
12481993	0	syringolide	8,19	P34	4,7	syringolide	P34	null	548062(Tax:3847)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	The P34 syringolide elicitor receptor interacts with a soybean photorespiration enzyme , NADH-dependent hydroxypyruvate reductase .
27039073	0	t-AUCB	37,43	Hsp27	66,71	t-AUCB	Hsp27	MESH:C524106	15507(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Quercetin sensitizes glioblastoma to t-AUCB by dual inhibition of Hsp27 and COX-2 in vitro and in vivo .
22382785	0	t-AUCB	0,6	sEH	20,23	t-AUCB	sEH	MESH:C524106	2053	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	t-AUCB , an improved sEH inhibitor , suppresses human glioblastoma cell growth by activating NF-kB-p65 .
22525341	0	t-AUCB	46,52	soluble_epoxide_hydrolase	9,34	t-AUCB	soluble epoxide hydrolase	MESH:C524106	2053	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	A potent soluble_epoxide_hydrolase inhibitor , t-AUCB , acts through PPARy to modulate the function of endothelial progenitor cells from patients with acute myocardial_infarction .
24225128	0	t-AUCB	46,52	soluble_epoxide_hydrolase	9,34	t-AUCB	soluble epoxide hydrolase	MESH:C524106	2053	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	A potent soluble_epoxide_hydrolase inhibitor , t-AUCB , modulates cholesterol balance and oxidized low density lipoprotein metabolism in adipocytes in vitro .
10220484	0	t-butylhydroquinone	80,99	UDP_glucuronosyltransferases	19,47	t-butylhydroquinone	UDP glucuronosyltransferases	null	135152	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of human UDP_glucuronosyltransferases -LRB- UGT1A6 , UGT1A9 , and UGT2B7 -RRB- by t-butylhydroquinone and 2,3,7,8-tetrachlorodibenzo-p-dioxin in Caco-2 cells .
9841862	0	t-butylhydroquinone	79,98	gamma-glutamylcysteine_synthetase	28,61	t-butylhydroquinone	gamma-glutamylcysteine synthetase	null	2729	Chemical	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	Inducible expression of the gamma-glutamylcysteine_synthetase light subunit by t-butylhydroquinone in HepG2 cells is not dependent on an antioxidant-responsive element .
23945499	0	tBHQ	20,24	Nrf2	4,8	tBHQ	Nrf2	MESH:C018855	4780	Chemical	Gene	activator|appos|START_ENTITY activator|amod|END_ENTITY	The Nrf2 activator , tBHQ , differentially affects early events following stimulation of Jurkat cells .
23632824	0	tBuZnOH	21,28	CO2	14,17	tBuZnOH	CO2	null	717	Chemical	Gene	species|amod|START_ENTITY END_ENTITY|nmod|species	Activation of CO2 by tBuZnOH species : efficient routes to novel nanomaterials based on zinc_carbonates .
10825652	0	tachykinin	12,22	NK-1	23,27	tachykinin	NK-1	MESH:D015320	6869	Chemical	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	The role of tachykinin NK-1 receptors in the area postrema of ferrets in emesis .
16222150	0	tachykinin	22,32	NK-1	8,12	tachykinin	NK-1	MESH:D015320	6869	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Role of NK-1 and NK-2 tachykinin receptor antagonism on the growth of human breast_carcinoma cell line MDA-MB-231 .
1724079	0	tachykinin	37,47	NK-1	0,4	tachykinin	NK-1	MESH:D015320	21333(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY class|nmod|receptors class|nsubj|receptors receptors|compound|END_ENTITY	NK-1 receptors are the only class of tachykinin receptors found on mouse cortical astrocytes .
8627566	0	tachykinin	78,88	NK-1	68,72	tachykinin	NK-1	MESH:D015320	6869	Chemical	Gene	antagonist|compound|START_ENTITY antagonist|nmod|A A|appos|END_ENTITY	In vitro and in vivo characterization of MDL 105,212 A , a nonpeptide NK-1 / NK-2 tachykinin receptor antagonist .
9503389	0	tachykinin	39,49	NK-1	50,54	tachykinin	NK-1	MESH:D015320	21333(Tax:10090)	Chemical	Gene	antagonist|amod|START_ENTITY antagonist|compound|END_ENTITY	-LSB- Pharmacological profile of sendide , a tachykinin NK-1 receptor antagonist -RSB- .
9583757	0	tachykinin	29,39	NK-1	15,19	tachykinin	NK-1	MESH:D015320	6869	Chemical	Gene	mechanisms|amod|START_ENTITY mechanisms|amod|END_ENTITY	Involvement of NK-1 and NK-2 tachykinin receptor mechanisms in jaw muscle activity reflexly evoked by inflammatory irritant application to the rat temporomandibular_joint .
7685768	0	tachykinin	130,140	NK-1_receptor	141,154	tachykinin	NK-1 receptor	MESH:D015320	24807(Tax:10116)	Chemical	Gene	activation|amod|START_ENTITY activation|compound|END_ENTITY	Failure of L-nitroarginine , a nitric_oxide synthase inhibitor , to affect hypotension and plasma protein extravasation produced by tachykinin NK-1_receptor activation in rats .
12126745	0	tachykinin	4,14	NK-2	15,19	tachykinin	NK-2	MESH:D015320	6865	Chemical	Gene	SR48968|amod|START_ENTITY SR48968|compound|END_ENTITY	The tachykinin NK-2 receptor antagonist SR48968 does not block noncholinergic contractions in unstable human bladder .
2166282	0	tachykinin	52,62	NK-2	37,41	tachykinin	NK-2	MESH:D015320	6865	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|amod|selective selective|amod|END_ENTITY	Synthesis and biological activity of NK-2 selective tachykinin antagonists containing D-tryptophan .
21855604	0	tachykinin	66,76	NK-2	61,65	tachykinin	NK-2	MESH:D015320	6865	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Distribution and pharmacological characterization of primate NK-2 tachykinin receptor in the central nervous system of the rhesus_monkey .
7523658	0	tachykinin	61,71	NK-2	72,76	tachykinin	NK-2	MESH:D015320	6865	Chemical	Gene	receptors|amod|START_ENTITY receptors|compound|NK-1 NK-1|compound|END_ENTITY	Use of selective antagonists for further characterization of tachykinin NK-2 , NK-1 and possible `` septide-selective '' receptors in guinea_pig bronchus .
7705977	0	tachykinin	61,71	NK-2	56,60	tachykinin	NK-2	MESH:D015320	6865	Chemical	Gene	antagonist|compound|START_ENTITY antagonist|compound|END_ENTITY	Solution conformation of c - -LSB- Gln-Trp-Phe-Gly-Leu-Met -RSB- , a NK-2 tachykinin antagonist .
8170503	0	tachykinin	49,59	NK-2	60,64	tachykinin	NK-2	MESH:D015320	6863	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Synergistic role of muscarinic acetylcholine and tachykinin NK-2 receptors in intestinal peristalsis .
8627566	0	tachykinin	78,88	NK-2	73,77	tachykinin	NK-2	MESH:D015320	6863	Chemical	Gene	antagonist|compound|START_ENTITY antagonist|compound|END_ENTITY	In vitro and in vivo characterization of MDL 105,212 A , a nonpeptide NK-1 / NK-2 tachykinin receptor antagonist .
8859022	0	tachykinin	73,83	NK-2	84,88	tachykinin	NK-2	MESH:D015320	6863	Chemical	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	Radioligand binding , autoradiographic and functional studies demonstrate tachykinin NK-2 receptors in dog urinary bladder .
1333561	0	tachykinin	45,55	NK-2_receptor	56,69	tachykinin	NK-2 receptor	MESH:D015320	6865	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|compound|END_ENTITY	N-terminal truncated analogs of men_10376 as tachykinin NK-2_receptor antagonists .
8234901	0	tachykinin	72,82	NK-2_receptor	83,96	tachykinin	NK-2 receptor	MESH:D015320	6865	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|compound|END_ENTITY	MEN 10,573 and MEN 10,612 , novel cyclic_pseudopeptides which are potent tachykinin NK-2_receptor antagonists .
8981832	0	tachykinin	37,47	NK-2_receptor	48,61	tachykinin	NK-2 receptor	MESH:D015320	100720631	Chemical	Gene	antagonist|compound|START_ENTITY antagonist|compound|END_ENTITY	-LSB- Pharmacological profiles of a novel tachykinin NK-2_receptor antagonist , TAC-363 -RSB- .
11532075	0	tachykinin	28,38	NK-3	23,27	tachykinin	NK-3	MESH:D015320	4824	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Synthesis , activity on NK-3 tachykinin receptor and conformational solution studies of scyliorhinin_II analogs modified at position 16 .
16331282	0	tachykinin	75,85	NK-3	70,74	tachykinin	NK-3	MESH:D015320	653013(Tax:9544)	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Distribution and pharmacological characterization of primate NK-1 and NK-3 tachykinin receptors in the central nervous system of the rhesus_monkey .
10658924	0	tachykinin	22,32	NK-3_receptor	33,46	tachykinin	NK-3 receptor	MESH:D015320	24808(Tax:10116)	Chemical	Gene	agonist|amod|START_ENTITY agonist|compound|END_ENTITY	SR142801 behaves as a tachykinin NK-3_receptor agonist on a spinal nociceptive reflex in the rat .
9802842	0	tachykinin	67,77	NK-3_receptor	78,91	tachykinin	NK-3 receptor	MESH:D015320	24808(Tax:10116)	Chemical	Gene	agonist|compound|START_ENTITY agonist|compound|END_ENTITY	Mechanism of action for reduction of ethanol intake in rats by the tachykinin NK-3_receptor agonist aminosenktide .
10225361	0	tachykinin	30,40	NK1	41,44	tachykinin	NK1	MESH:D015320	21333(Tax:10090)	Chemical	Gene	antagonist|amod|START_ENTITY antagonist|nummod|END_ENTITY	Opioid activity of sendide , a tachykinin NK1 receptor antagonist .
10422769	0	tachykinin	27,37	NK1	38,41	tachykinin	NK1	MESH:D015320	6869	Chemical	Gene	antagonist|amod|START_ENTITY antagonist|compound|END_ENTITY	Effect of MEN_11467 , a new tachykinin NK1 receptor antagonist , in acute_rectocolitis induced by acetic_acid in guinea-pigs .
10422788	0	tachykinin	95,105	NK1	106,109	tachykinin	NK1	MESH:D015320	6869	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|compound|END_ENTITY	Correlation between binding characteristics and functional antagonism in human glioma cells by tachykinin NK1 receptor antagonists .
10443564	0	tachykinin	4,14	NK1	15,18	tachykinin	NK1	MESH:D015320	6869	Chemical	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	The tachykinin NK1 receptor in the brain : pharmacology and putative functions .
12466234	0	tachykinin	31,41	NK1	42,45	tachykinin	NK1	MESH:D015320	21333(Tax:10090)	Chemical	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	Functional characterization of tachykinin NK1 receptors in the mouse uterus .
1282072	0	tachykinin	39,49	NK1	27,30	tachykinin	NK1	MESH:D015320	6869	Chemical	Gene	characteristics|compound|START_ENTITY characteristics|compound|END_ENTITY	A pharmacological study of NK1 and NK2 tachykinin receptor characteristics in the rat isolated urinary bladder .
12969772	0	tachykinin	4,14	NK1	15,18	tachykinin	NK1	MESH:D015320	21333(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	The tachykinin NK1 receptor is crucial for the development of non-atopic airway inflammation and hyperresponsiveness .
1372967	0	tachykinin	24,34	NK1	12,15	tachykinin	NK1	MESH:D015320	21333(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Evidence of NK1 and NK2 tachykinin receptors and their involvement in histamine release in a murine mast cell line .
1658233	0	tachykinin	23,33	NK1	19,22	tachykinin	NK1	MESH:D015320	6869	Chemical	Gene	agonist|compound|START_ENTITY agonist|compound|END_ENTITY	Ranakinin : a novel NK1 tachykinin receptor agonist isolated with neurokinin_B from the brain of the frog Rana ridibunda .
16651388	0	tachykinin	38,48	NK1	34,37	tachykinin	NK1	MESH:D015320	6869	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Immunolocalization of full-length NK1 tachykinin receptors in human tumors .
16949572	0	tachykinin	21,31	NK1	32,35	tachykinin	NK1	MESH:D015320	21333(Tax:10090)	Chemical	Gene	antagonism|compound|START_ENTITY antagonism|nummod|END_ENTITY	Beneficial effect of tachykinin NK1 receptor antagonism in the development of hapten-induced colitis in mice .
1720881	0	tachykinin	12,22	NK1	8,11	tachykinin	NK1	MESH:D015320	21333(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|nummod|END_ENTITY	Role of NK1 tachykinin receptors in thermonociception : effect of -LRB- + / - -RRB- - CP 96,345 , a non-peptide substance_P antagonist , on the hot plate test in mice .
7509285	0	tachykinin	79,89	NK1	90,93	tachykinin	NK1	MESH:D015320	6869	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Effect of scyliorhinin_I and synthetic scyliorhinin_I derivatives at mammalian tachykinin NK1 , NK2 and NK3 receptors .
7509286	0	tachykinin	83,93	NK1	94,97	tachykinin	NK1	MESH:D015320	6869	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	In vitro and in vivo biological activities of SR140333 , a novel potent non-peptide tachykinin NK1 receptor antagonist .
7510780	0	tachykinin	75,85	NK1	71,74	tachykinin	NK1	MESH:D015320	6869	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	SR_140333 , a novel , selective , and potent nonpeptide antagonist of the NK1 tachykinin receptor : characterization on the U373MG cell line .
7530573	0	tachykinin	31,41	NK1	27,30	tachykinin	NK1	MESH:D015320	6869	Chemical	Gene	vasodilatation|amod|START_ENTITY vasodilatation|nummod|END_ENTITY	Inhibition by SR_140333 of NK1 tachykinin receptor-evoked , nitric_oxide-dependent vasodilatation in the hamster cheek pouch microvasculature in vivo .
7533096	0	tachykinin	109,119	NK1	120,123	tachykinin	NK1	MESH:D015320	6869	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|nummod|END_ENTITY	Differential inhibition of foot tapping and chromodacryorrhoea in gerbils by CNS penetrant and non-penetrant tachykinin NK1 receptor antagonists .
7687062	0	tachykinin	15,25	NK1	92,95	tachykinin	NK1	MESH:D015320	6869	Chemical	Gene	antagonists|compound|START_ENTITY act|nsubj|antagonists act|nmod|epitopes epitopes|nmod|segments segments|nmod|END_ENTITY	Two nonpeptide tachykinin antagonists act through epitopes on corresponding segments of the NK1 and NK2_receptors .
9543241	0	tachykinin	92,102	NK1	103,106	tachykinin	NK1	MESH:D015320	6869	Chemical	Gene	antagonist|amod|START_ENTITY antagonist|nummod|END_ENTITY	Pharmacology of the peptidomimetic , MEN_11149 , a new potent , selective and orally effective tachykinin NK1 receptor antagonist .
9572295	0	tachykinin	31,41	NK1	27,30	tachykinin	NK1	MESH:D015320	6869	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Functional coupling of the NK1 tachykinin receptor to phospholipase D in chinese_hamster ovary cells and astrocytoma cells .
9703462	0	tachykinin	118,128	NK1	114,117	tachykinin	NK1	MESH:D015320	6869	Chemical	Gene	antagonist|compound|START_ENTITY antagonist|compound|END_ENTITY	2-Nitrophenylcarbamoyl - -LRB- S -RRB- - prolyl - -LRB- S -RRB- -3 - -LRB- 2-naphthyl -RRB- alanyl-N-benzyl-N - methylamide -LRB- SDZ_NKT 343 -RRB- , a potent human NK1 tachykinin receptor antagonist with good oral analgesic activity in chronic_pain models .
9732370	0	tachykinin	76,86	NK1	72,75	tachykinin	NK1	MESH:D015320	21333(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Substance_P induction of itch-associated response mediated by cutaneous NK1 tachykinin receptors in mice .
9784098	0	tachykinin	94,104	NK1	105,108	tachykinin	NK1	MESH:D015320	6869	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|compound|END_ENTITY	Axially chiral N-benzyl-N ,7 - dimethyl-5-phenyl-1 , _ 7-naphthyridine-6-carboxamide derivatives as tachykinin NK1 receptor antagonists : determination of the absolute stereochemical requirements .
9888463	0	tachykinin	97,107	NK1	108,111	tachykinin	NK1	MESH:D015320	6869	Chemical	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	Substance_P activates responses correlated with tumour growth in human glioma cell lines bearing tachykinin NK1 receptors .
10082830	0	tachykinin	38,48	NK1_receptor	49,61	tachykinin	NK1 receptor	MESH:D015320	403815(Tax:9615)	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|amod|END_ENTITY	The site of the anti-emetic action of tachykinin NK1_receptor antagonists may exist in the medullary area adjacent to the semicompact part of the nucleus ambiguus .
10877607	0	tachykinin	86,96	NK1_receptor	97,109	tachykinin	NK1 receptor	MESH:D015320	100135626(Tax:10141)	Chemical	Gene	agonists|amod|START_ENTITY agonists|amod|END_ENTITY	Differences in circular muscle contraction and peristaltic motor inhibition caused by tachykinin NK1_receptor agonists in the guinea-pig small intestine .
12372904	0	tachykinin	45,55	NK1_receptor	56,68	tachykinin	NK1 receptor	MESH:D015320	100135626(Tax:10141)	Chemical	Gene	ezlopitant|amod|START_ENTITY ezlopitant|amod|END_ENTITY	Anti-emetic activity of the novel nonpeptide tachykinin NK1_receptor antagonist ezlopitant -LRB- CJ-11 ,974 -RRB- against acute and delayed cisplatin-induced emesis in the ferret .
17141213	0	tachykinin	57,67	NK1_receptor	68,80	tachykinin	NK1 receptor	MESH:D015320	24807(Tax:10116)	Chemical	Gene	antagonist|amod|START_ENTITY antagonist|amod|END_ENTITY	Differential effects of dexamethasone , ondansetron and a tachykinin NK1_receptor antagonist -LRB- GR205171 -RRB- on cisplatin-induced changes in behaviour , food intake , pica and gastric function in rats .
7509748	0	tachykinin	30,40	NK1_receptor	41,53	tachykinin	NK1 receptor	MESH:D015320	100135626(Tax:10141)	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|amod|END_ENTITY	Differences in the effects of tachykinin NK1_receptor antagonists : neuronal versus smooth muscle tissues .
7530576	0	tachykinin	14,24	NK1_receptor	25,37	tachykinin	NK1 receptor	MESH:D015320	24807(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|amod|END_ENTITY	Effect of the tachykinin NK1_receptor antagonists , RP_67580 and SR_140333 , on electrically-evoked substance P release from rat spinal cord .
7922147	0	tachykinin	33,43	NK1_receptor	44,56	tachykinin	NK1 receptor	MESH:D015320	100135626(Tax:10141)	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|amod|END_ENTITY	Rational design of high affinity tachykinin NK1_receptor antagonists .
8528583	0	tachykinin	32,42	NK1_receptor	43,55	tachykinin	NK1 receptor	MESH:D015320	24807(Tax:10116)	Chemical	Gene	antagonist|amod|START_ENTITY antagonist|amod|END_ENTITY	Antinociceptive activity of the tachykinin NK1_receptor antagonist , CP-99 ,994 , in conscious gerbils .
9373180	0	tachykinin	37,47	NK1_receptor	14,26	tachykinin	NK1 receptor	MESH:D015320	6869	Chemical	Gene	selectivity|compound|START_ENTITY regulates|dobj|selectivity regulates|nsubj|Gly166 Gly166|nmod|END_ENTITY	Gly166 in the NK1_receptor regulates tachykinin selectivity and receptor conformation .
9641542	0	tachykinin	11,21	NK1_receptor	22,34	tachykinin	NK1 receptor	MESH:D015320	100135626(Tax:10141)	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|amod|END_ENTITY	Effects of tachykinin NK1_receptor antagonists on vagal_hyperreactivity_and_neuronal_M2 muscarinic receptor function in antigen challenged guinea-pigs .
10694220	0	tachykinin	8,18	NK2	19,22	tachykinin	NK2	MESH:D015320	6865	Chemical	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	Role of tachykinin NK2 receptors in normal and altered rectal sensitivity in rats .
11302484	0	tachykinin	81,91	NK2	102,105	tachykinin	NK2	MESH:D015320	6865	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|appos|END_ENTITY	A family of depsi-peptide_fungal_metabolites , as selective and competitive human tachykinin receptor -LRB- NK2 -RRB- antagonists : fermentation , isolation , physico-chemical properties , and biological activity .
11384776	0	tachykinin	28,38	NK2	39,42	tachykinin	NK2	MESH:D015320	6863	Chemical	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	Differential alterations in tachykinin NK2 receptors in isolated colonic circular smooth muscle in inflammatory_bowel_disease and idiopathic_chronic_constipation .
11522614	0	tachykinin	8,18	NK2	19,22	tachykinin	NK2	MESH:D015320	6863	Chemical	Gene	antagonist|compound|START_ENTITY antagonist|nummod|END_ENTITY	A novel tachykinin NK2 receptor antagonist prevents motility-stimulating effects of neurokinin_A in small intestine .
15023054	0	tachykinin	79,89	NK2	74,77	tachykinin	NK2	MESH:D015320	6863	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Evidence for the proximity of the extreme N-terminus of the neurokinin-2 -LRB- NK2 -RRB- tachykinin receptor to Cys167 in the putative fourth transmembrane helix .
1664768	0	tachykinin	42,52	NK2	38,41	tachykinin	NK2	MESH:D015320	6865	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Further evidence for the existence of NK2 tachykinin receptor subtypes .
1723045	0	tachykinin	4,14	NK2	0,3	tachykinin	NK2	MESH:D015320	6865	Chemical	Gene	receptors|compound|START_ENTITY receptors|nummod|END_ENTITY	NK2 tachykinin receptors and contraction of circular muscle of the human colon : characterization of the NK2_receptor subtype .
7698194	0	tachykinin	23,33	NK2	34,37	tachykinin	NK2	MESH:D015320	6865	Chemical	Gene	mechanism|nmod|START_ENTITY END_ENTITY|nsubj|mechanism	Different mechanism of tachykinin NK2 receptor blockade by SR_48968 and MEN 10,627 in the guinea-pig isolated gallbladder and colon .
8385622	0	tachykinin	115,125	NK2	126,129	tachykinin	NK2	MESH:D015320	6863	Chemical	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Characterisation of a novel , selective radioligand , -LSB- 125I -RSB- -LSB- Lys5 , Tyr -LRB- I2 -RRB- 7 , MeLeu9 , Nle10 -RSB- neurokinin_A - -LRB- 4-10 -RRB- , for the tachykinin NK2 receptor in rat fundus .
8788437	0	tachykinin	75,85	NK2	86,89	tachykinin	NK2	MESH:D015320	6863	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	-LSB- 3H -RSB- -LSB- beta-Ala8 -RSB- neurokinin_A - -LRB- 4-10 -RRB- : a novel , selective radioligand for the tachykinin NK2 receptor .
9413022	0	tachykinin	82,92	NK2	93,96	tachykinin	NK2	MESH:D015320	6863	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Biochemical and pharmacological activities of SR_144190 , a new potent non-peptide tachykinin NK2 receptor antagonist .
15659312	0	tachykinin	73,83	NK2_receptor	84,96	tachykinin	NK2 receptor	MESH:D015320	100720631	Chemical	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Cigarette smoke increases mucosal permeability in guinea_pig trachea via tachykinin NK2_receptor activation .
1665897	0	tachykinin	48,58	NK2_receptor	114,126	tachykinin	NK2 receptor	MESH:D015320	6865	Chemical	Gene	Neuropeptide_gamma|appos|START_ENTITY acts|nsubj|Neuropeptide_gamma acts|nmod|END_ENTITY	Neuropeptide_gamma , the most potent contractile tachykinin in human isolated bronchus , acts via a ` non-classical ' NK2_receptor .
1723045	0	tachykinin	4,14	NK2_receptor	104,116	tachykinin	NK2 receptor	MESH:D015320	6865	Chemical	Gene	receptors|compound|START_ENTITY receptors|dep|characterization characterization|nmod|subtype subtype|amod|END_ENTITY	NK2 tachykinin receptors and contraction of circular muscle of the human colon : characterization of the NK2_receptor subtype .
7562907	0	tachykinin	57,67	NK2_receptor	68,80	tachykinin	NK2 receptor	MESH:D015320	100720631	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|amod|END_ENTITY	New spiropiperidines as potent and selective non-peptide tachykinin NK2_receptor antagonists .
7737306	0	tachykinin	50,60	NK2_receptor	61,73	tachykinin	NK2 receptor	MESH:D015320	100720631	Chemical	Gene	antagonist|amod|START_ENTITY antagonist|amod|END_ENTITY	Antibronchospastic activity of MEN10 ,627 , a novel tachykinin NK2_receptor antagonist , in guinea-pig airways .
7922121	0	tachykinin	33,43	NK2_receptor	44,56	tachykinin	NK2 receptor	MESH:D015320	6865	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|amod|END_ENTITY	Rational design of high affinity tachykinin NK2_receptor antagonists .
9272723	0	tachykinin	22,32	NK2_receptor	33,45	tachykinin	NK2 receptor	MESH:D015320	6865	Chemical	Gene	antagonist|amod|START_ENTITY antagonist|amod|END_ENTITY	MEN_11 ,420 , a peptide tachykinin NK2_receptor antagonist , reduces motor responses induced by the intravesical administration of capsaicin in vivo .
15003355	0	tachykinin	37,47	NK3	33,36	tachykinin	NK3	MESH:D015320	100135627(Tax:10141)	Chemical	Gene	agonist|compound|START_ENTITY agonist|compound|END_ENTITY	Stimulatory effect of PG-KII , an NK3 tachykinin receptor agonist , on isolated pancreatic acini : species-related differences .
17306250	0	tachykinin	8,18	NK3	19,22	tachykinin	NK3	MESH:D015320	4824	Chemical	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	Role of tachykinin NK3 receptors in the release and effects of nerve_growth_factor in human isolated bronchi .
1370464	0	tachykinin	33,43	NKD	0,3	tachykinin	NKD	MESH:D015320	44843(Tax:7227)	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|appos|receptor	NKD , a developmentally regulated tachykinin receptor in Drosophila .
10780997	0	tachykinin	27,37	Neurokinin_B	0,12	tachykinin	Neurokinin B	MESH:D015320	100715825	Chemical	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Neurokinin_B - and specific tachykinin NK -LRB- 3 -RRB- receptor agonists-induced airway hyperresponsiveness in the guinea-pig .
15219818	0	tachykinin	76,86	Substance_P	0,11	tachykinin	Substance P	MESH:D015320	21333(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY induces|nmod|receptor induces|nsubj|END_ENTITY	Substance_P induces inward current and regulates pacemaker currents through tachykinin NK1 receptor in cultured interstitial cells of Cajal of murine small intestine .
9732370	0	tachykinin	76,86	Substance_P	0,11	tachykinin	Substance P	MESH:D015320	21333(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY mediated|nmod|receptors mediated|nsubj|induction induction|amod|END_ENTITY	Substance_P induction of itch-associated response mediated by cutaneous NK1 tachykinin receptors in mice .
9888463	0	tachykinin	97,107	Substance_P	0,11	tachykinin	Substance P	MESH:D015320	6863	Chemical	Gene	receptors|amod|START_ENTITY bearing|dobj|receptors correlated|xcomp|bearing correlated|nsubj|responses responses|amod|END_ENTITY	Substance_P activates responses correlated with tumour growth in human glioma cell lines bearing tachykinin NK1 receptors .
21168392	0	tachykinin	90,100	neurokinin-1	110,122	tachykinin	neurokinin-1	MESH:D015320	6863	Chemical	Gene	receptor|compound|START_ENTITY property|nmod|receptor END_ENTITY|nsubj|property	The N-terminal domain of human hemokinin-1 influences functional selectivity property for tachykinin receptor neurokinin-1 .
8797856	0	tachykinin	101,111	neurokinin-1	88,100	tachykinin	neurokinin-1	MESH:D015320	6863	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	The use of photolabelled peptides to localize the substance-P-binding site in the human neurokinin-1 tachykinin receptor .
15023054	0	tachykinin	79,89	neurokinin-2	60,72	tachykinin	neurokinin-2	MESH:D015320	6863	Chemical	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Evidence for the proximity of the extreme N-terminus of the neurokinin-2 -LRB- NK2 -RRB- tachykinin receptor to Cys167 in the putative fourth transmembrane helix .
1711392	0	tachykinin	13,23	neurokinin-2	108,120	tachykinin	neurokinin-2	MESH:D015320	6863	Chemical	Gene	localization|compound|START_ENTITY Phylogeny|nmod|localization Phylogeny|dep|absence absence|nmod|sites sites|amod|END_ENTITY	Phylogeny of tachykinin receptor localization in the vertebrate central nervous system : apparent absence of neurokinin-2 and neurokinin-3 binding sites in the human brain .
9062074	0	tachykinin	62,72	neurokinin_1	49,61	tachykinin	neurokinin 1	MESH:D015320	6863	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|amod|END_ENTITY	Absorption , emission , and chiroptical spectra of neurokinin_1 tachykinin receptor antagonists : the role of charge-transfer states on the biological activity .
1465196	0	tachykinin	20,30	neurokinin_B	31,43	tachykinin	neurokinin B	MESH:D015320	29191(Tax:10116)	Chemical	Gene	precursor|compound|START_ENTITY precursor|compound|END_ENTITY	Localization of the tachykinin neurokinin_B precursor peptide in rat brain by immunocytochemistry and in situ hybridization .
1658233	0	tachykinin	23,33	neurokinin_B	65,77	tachykinin	neurokinin B	MESH:D015320	6866	Chemical	Gene	agonist|compound|START_ENTITY agonist|acl|isolated isolated|nmod|END_ENTITY	Ranakinin : a novel NK1 tachykinin receptor agonist isolated with neurokinin_B from the brain of the frog Rana ridibunda .
20939761	0	tachykinin	33,43	neurokinin_B	79,91	tachykinin	neurokinin B	MESH:D015320	100715825	Chemical	Gene	NK|compound|START_ENTITY effect|nmod|NK effect|dep|END_ENTITY	Bronchoconstrictor effect of the tachykinin NK - receptor agonists -LSB- MePhe -RSB- - neurokinin_B and senktide in the isolated guinea_pig lung .
3025361	0	tachykinin	66,76	neurokinin_B	4,16	tachykinin	neurokinin B	MESH:D015320	29191(Tax:10116)	Chemical	Gene	sites|amod|START_ENTITY label|dobj|sites label|nsubj|eledoisin eledoisin|amod|END_ENTITY	-LSB- 3H -RSB- neurokinin_B and 125I-Bolton Hunter eledoisin label identical tachykinin binding sites in the rat brain .
7530207	0	tachykinin	58,68	neurokinin_B	34,46	tachykinin	neurokinin B	MESH:D015320	6866	Chemical	Gene	binding|nmod|START_ENTITY NK3_receptors|amod|binding NK3_receptors|amod|END_ENTITY	Characterisation of -LSB- 125I -RSB- -LSB- MePhe7 -RSB- neurokinin_B binding to tachykinin NK3_receptors : evidence for interspecies variance .
7969819	0	tachykinin	80,90	neurokinin_B	19,31	tachykinin	neurokinin B	MESH:D015320	29191(Tax:10116)	Chemical	Gene	NK1|compound|START_ENTITY involvement|nmod|NK1 involvement|nmod|effects effects|nmod|motility motility|amod|END_ENTITY	In vivo effects of neurokinin_B on rat urinary bladder motility : involvement of tachykinin NK1 and NK2_receptors .
1382977	0	tachykinin	73,83	substance_K	136,147	tachykinin	substance K	MESH:D015320	6863	Chemical	Gene	receptors|compound|START_ENTITY specificity|nmod|receptors involved|nmod|specificity involved|nmod|formation formation|nmod|receptors receptors|compound|END_ENTITY	Delineation of structural domains involved in the subtype specificity of tachykinin receptors through chimeric formation of substance_P / substance_K receptors .
12754055	0	tachykinin	76,86	substance_P	121,132	tachykinin	substance P	MESH:D015320	6863	Chemical	Gene	receptor|compound|START_ENTITY antibody|nmod|receptor derived|nmod|antibody derived|nmod|END_ENTITY	Pharmacological properties of peptides derived from an antibody against the tachykinin NK1 receptor for the neuropeptide substance_P .
12754055	3	tachykinin	277,287	substance_P	324,335	tachykinin	substance P	MESH:D015320	6863	Chemical	Gene	receptor|amod|START_ENTITY 423|nmod|receptor 423|nmod|END_ENTITY	37 -LRB- 2000 -RRB- 423 -RSB- against the tachykinin NK -LRB- 1 -RRB- receptor for the neuropeptide substance_P .
1382977	0	tachykinin	73,83	substance_P	124,135	tachykinin	substance P	MESH:D015320	6863	Chemical	Gene	receptors|compound|START_ENTITY specificity|nmod|receptors involved|nmod|specificity involved|nmod|formation formation|nmod|receptors receptors|compound|END_ENTITY	Delineation of structural domains involved in the subtype specificity of tachykinin receptors through chimeric formation of substance_P / substance_K receptors .
16127708	0	tachykinin	23,33	substance_P	83,94	tachykinin	substance P	MESH:D015320	6863	Chemical	Gene	distribution|amod|START_ENTITY differences|nmod|distribution differences|dep|evidence evidence|dep|_ _|nsubj|END_ENTITY	Species differences in tachykinin receptor distribution : further evidence that the substance_P -LRB- NK1 -RRB- _ receptor predominates in human brain .
1720881	0	tachykinin	12,22	substance_P	96,107	tachykinin	substance P	MESH:D015320	21333(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY Role|nmod|receptors Role|dep|CP CP|appos|antagonist antagonist|compound|END_ENTITY	Role of NK1 tachykinin receptors in thermonociception : effect of -LRB- + / - -RRB- - CP 96,345 , a non-peptide substance_P antagonist , on the hot plate test in mice .
26084224	0	tachykinin	214,224	substance_P	74,85	tachykinin	substance P	MESH:D015320	6863	Chemical	Gene	antagonist|amod|START_ENTITY profile|nmod|antagonist due|nmod|profile due|nsubj|action action|nmod|D-Arg D-Arg|acl|-RSB- -RSB-|dobj|antagonist antagonist|compound|END_ENTITY	The antiproliferative action of -LSB- D-Arg -LRB- 1 -RRB- , D-Phe -LRB- 5 -RRB- , D-Trp -LRB- 7,9 -RRB- , LEU -LRB- 11 -RRB- -RSB- substance_P analogue antagonist against small-cell - and non-small-cell_lung_cancer cells could be due to the pharmacological profile of its tachykinin receptor antagonist .
6200746	0	tachykinin	31,41	substance_P	60,71	tachykinin	substance P	MESH:D015320	6863	Chemical	Gene	START_ENTITY|acl:relcl|differs differs|nmod|END_ENTITY	Substance_K : a novel mammalian tachykinin that differs from substance_P in its pharmacological profile .
7520910	0	tachykinin	115,125	substance_P	36,47	tachykinin	substance P	MESH:D015320	6863	Chemical	Gene	sequence|compound|START_ENTITY recognition|nmod|sequence important|nmod|recognition Identification|amod|important Identification|nmod|epitope epitope|nmod|receptor receptor|compound|END_ENTITY	Identification of an epitope in the substance_P receptor important for recognition of the common carboxyl-terminal tachykinin sequence .
8841832	0	tachykinin	15,25	substance_P	92,103	tachykinin	substance P	MESH:D015320	21333(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY Involvement|nmod|receptors induced|nsubj|Involvement induced|nmod|END_ENTITY	Involvement of tachykinin receptors in oedema formation and plasma extravasation induced by substance_P , neurokinin_A , and neurokinin_B in mouse ear .
8985172	0	tachykinin	126,136	substance_P	10,21	tachykinin	substance P	MESH:D015320	6863	Chemical	Gene	antagonists|compound|START_ENTITY characterization|nmod|antagonists Effect|dep|characterization Effect|nmod|END_ENTITY	Effect of substance_P on cytokine production by human astrocytic cells and blood mononuclear cells : characterization of novel tachykinin receptor antagonists .
23256992	0	tachykinin	14,24	tacr1a	36,42	tachykinin	tacr1a	MESH:D015320	100003539(Tax:7955)	Chemical	Gene	receptors|compound|START_ENTITY receptors|dep|END_ENTITY	Expression of tachykinin receptors -LRB- tacr1a and tacr1b -RRB- in zebrafish : influence of cocaine and opioid receptors .
1335337	0	tachykinins	97,108	NK1	112,115	tachykinins	NK1	MESH:D015320	6869	Chemical	Gene	START_ENTITY|nmod|receptors receptors|compound|END_ENTITY	Use of selective antagonists to dissociate the central cardiovascular and behavioural effects of tachykinins on NK1 and NK2 receptors in the rat .
16269189	0	tachykinins	27,38	TNFalpha	148,156	tachykinins	TNFalpha	MESH:D015320	21926(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Pivotal role of endogenous tachykinins and the NK1_receptor in mediating leukocyte accumulation , in the absence of oedema formation , in response to TNFalpha in the cutaneous microvasculature .
1713036	0	tachykinins	31,42	substance_P	56,67	tachykinins	substance P	MESH:D015320	6863	Chemical	Gene	analysis|nmod|START_ENTITY analysis|dep|END_ENTITY	Conformational analysis of the tachykinins in solution : substance_P and physalaemin .
10452094	0	tacrine	97,104	AChE	122,126	tacrine	AChE	MESH:D013619	83817(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Attenuation of scopolamine-induced deficits_in_navigational_memory performance in rats by bis -LRB- 7 -RRB- - tacrine , a novel dimeric AChE inhibitor .
17158047	0	tacrine	55,62	AChE	105,109	tacrine	AChE	MESH:D013619	43	Chemical	Gene	derivatives|amod|START_ENTITY relationship|nmod|derivatives Quantitative|dobj|relationship Quantitative|nmod|activity activity|appos|END_ENTITY	Quantitative structure-activity relationship -LRB- QSAR -RRB- of tacrine derivatives against acetylcholinesterase -LRB- AChE -RRB- activity using variable selections .
20545360	3	tacrine	702,709	AChE	662,666	tacrine	AChE	MESH:D013619	43	Chemical	Gene	potent|nmod|START_ENTITY inhibit|xcomp|potent inhibit|dobj|acetyl acetyl|dep|and_butyrylcholinesterase and_butyrylcholinesterase|appos|END_ENTITY	At nano - and subnanomolar concentrations they inhibit human acetyl - _ and_butyrylcholinesterase -LRB- AChE and BuChE -RRB- , being more potent than tacrine .
26438408	0	tacrine	69,76	AChE	124,128	tacrine	AChE	MESH:D013619	43	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|acetylcholinesterase acetylcholinesterase|appos|END_ENTITY	Combined 3D-QSAR , molecular docking , and molecular dynamics study of tacrine derivatives as potential acetylcholinesterase -LRB- AChE -RRB- inhibitors of Alzheimer 's _ disease .
7636741	5	tacrine	819,826	AChE	835,839	tacrine	BChE	MESH:D013619	590	Chemical	Gene	selectivity|appos|START_ENTITY determine|dobj|selectivity determine|nmod|END_ENTITY	The purpose of this study was to determine the selectivity of physostigmine , metrifonate , methanesulfonyl_fluoride and tetrahydroaminoacridine -LRB- tacrine -RRB- toward AChE as compared with butyrylcholinesterase -LRB- BChE -RRB- in human cortex .
8993489	0	tacrine	59,66	Apolipoprotein_E	0,16	tacrine	Apolipoprotein E	MESH:D013619	348	Chemical	Gene	therapy|amod|START_ENTITY END_ENTITY|nmod|therapy	Apolipoprotein_E genotype and gender influence response to tacrine therapy .
12014965	0	tacrine	12,19	acetylcholinesterase	33,53	tacrine	acetylcholinesterase	MESH:D013619	83817(Tax:10116)	Chemical	Gene	congeners|nsubj|START_ENTITY congeners|nmod|inhibitors inhibitors|amod|END_ENTITY	Homodimeric tacrine congeners as acetylcholinesterase inhibitors .
12445575	0	tacrine	82,89	acetylcholinesterase	26,46	tacrine	acetylcholinesterase	MESH:D013619	83817(Tax:10116)	Chemical	Gene	comparison|acl|START_ENTITY Effects|dep|comparison Effects|nmod|huperzine_A huperzine_A|nmod|isoforms isoforms|amod|END_ENTITY	Effects of huperzine_A on acetylcholinesterase isoforms in vitro : comparison with tacrine , donepezil , rivastigmine and physostigmine .
17158047	0	tacrine	55,62	acetylcholinesterase	83,103	tacrine	acetylcholinesterase	MESH:D013619	43	Chemical	Gene	derivatives|amod|START_ENTITY relationship|nmod|derivatives Quantitative|dobj|relationship Quantitative|nmod|activity activity|amod|END_ENTITY	Quantitative structure-activity relationship -LRB- QSAR -RRB- of tacrine derivatives against acetylcholinesterase -LRB- AChE -RRB- activity using variable selections .
17917719	0	tacrine	59,66	acetylcholinesterase	28,48	tacrine	acetylcholinesterase	MESH:D013619	83817(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Dose-related effects of the acetylcholinesterase inhibitor tacrine on cocaine and food self-administration in rats .
20006600	0	tacrine	102,109	acetylcholinesterase	71,91	tacrine	acetylcholinesterase	MESH:D013619	83817(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|administration administration|nmod|inhibitor inhibitor|amod|END_ENTITY	Differential effects of systemic and intraseptal administration of the acetylcholinesterase inhibitor tacrine on the recovery of spatial behavior in an animal model of diencephalic_amnesia .
20047331	0	tacrine	89,96	acetylcholinesterase	131,151	tacrine	acetylcholinesterase	MESH:D013619	43	Chemical	Gene	START_ENTITY|nmod|combination combination|nmod|inhibition inhibition|amod|END_ENTITY	Design , synthesis , biological properties , and molecular modeling investigations of novel tacrine derivatives with a combination of acetylcholinesterase inhibition and cannabinoid CB1 receptor antagonism .
20466502	0	tacrine	117,124	acetylcholinesterase	23,43	tacrine	acetylcholinesterase	MESH:D013619	43	Chemical	Gene	products|nmod|START_ENTITY profiling|nmod|products bioactivity|acl|profiling bioactivity|compound|END_ENTITY	Production and on-line acetylcholinesterase bioactivity profiling of chemical and biological degradation products of tacrine .
21152577	0	tacrine	8,15	acetylcholinesterase	30,50	tacrine	acetylcholinesterase	MESH:D013619	43	Chemical	Gene	conjugates|compound|START_ENTITY conjugates|amod|END_ENTITY	Clicked tacrine conjugates as acetylcholinesterase and b-amyloid directed compounds .
2259472	0	tacrine	59,66	acetylcholinesterase	35,55	tacrine	acetylcholinesterase	MESH:D013619	540446(Tax:9913)	Chemical	Gene	Reversibility|nmod|START_ENTITY Reversibility|nmod|inhibition inhibition|nmod|END_ENTITY	Reversibility of the inhibition of acetylcholinesterase by tacrine .
23459299	0	tacrine	4,11	acetylcholinesterase	23,43	tacrine	acetylcholinesterase	MESH:D013619	43	Chemical	Gene	analogs|amod|START_ENTITY analogs|nmod|inhibitors inhibitors|amod|END_ENTITY	New tacrine analogs as acetylcholinesterase inhibitors - theoretical study with chemometric analysis .
25445524	0	tacrine	74,81	acetylcholinesterase	92,112	tacrine	acetylcholinesterase	MESH:D013619	43	Chemical	Gene	dimers|amod|START_ENTITY dimers|nmod|inhibitors inhibitors|amod|END_ENTITY	Synthesis , biological activity , and biopharmaceutical characterization of tacrine dimers as acetylcholinesterase inhibitors .
26438408	0	tacrine	69,76	acetylcholinesterase	102,122	tacrine	acetylcholinesterase	MESH:D013619	43	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Combined 3D-QSAR , molecular docking , and molecular dynamics study of tacrine derivatives as potential acetylcholinesterase -LRB- AChE -RRB- inhibitors of Alzheimer 's _ disease .
26558196	0	tacrine	23,30	acetylcholinesterase	62,82	tacrine	acetylcholinesterase	MESH:D013619	11423(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|retina retina|nmod|mice mice|amod|END_ENTITY	The protective role of tacrine and donepezil in the retina of acetylcholinesterase knockout mice .
8527921	0	tacrine	40,47	acetylcholinesterase	16,36	tacrine	acetylcholinesterase	MESH:D013619	43	Chemical	Gene	chromatography|amod|START_ENTITY Purification|nmod|chromatography Purification|nmod|END_ENTITY	Purification of acetylcholinesterase by tacrine affinity chromatography .
9357518	0	tacrine	6,13	acetylcholinesterase	92,112	tacrine	acetylcholinesterase	MESH:D013619	43	Chemical	Gene	analogues|compound|START_ENTITY analogues|dep|inhibitors inhibitors|compound|END_ENTITY	Novel tacrine analogues for potential use against Alzheimer 's _ disease : potent and selective acetylcholinesterase inhibitors and 5-HT uptake inhibitors .
9851542	0	tacrine	35,42	acetylcholinesterase	53,73	tacrine	acetylcholinesterase	MESH:D013619	83817(Tax:10116)	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Pressor and bradycardic effects of tacrine and other acetylcholinesterase inhibitors in the rat .
10886308	0	tacrine	57,64	apolipoprotein_E	4,20	tacrine	apolipoprotein E	MESH:D013619	348	Chemical	Gene	allele|acl|START_ENTITY allele|amod|END_ENTITY	The apolipoprotein_E epsilon4 allele and the response to tacrine therapy in Alzheimer 's _ disease .
23639542	0	tacrine	12,19	butyrylcholinesterase	45,66	tacrine	butyrylcholinesterase	MESH:D013619	590	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	NO-donating tacrine derivatives as potential butyrylcholinesterase inhibitors with vasorelaxation activity .
15834447	0	tacrine	11,18	histamine-N-methyltransferase	39,68	tacrine	histamine-N-methyltransferase	MESH:D013619	3176	Chemical	Gene	Actions|nmod|START_ENTITY Actions|nmod|END_ENTITY	Actions of tacrine and galanthamine on histamine-N-methyltransferase .
15778421	0	tacrolimus	23,33	ABCB1	80,85	tacrolimus	ABCB1	MESH:D016559	5243	Chemical	Gene	START_ENTITY|acl|dosing dosing|nmod|END_ENTITY	Sequential analysis of tacrolimus dosing in adult lung transplant patients with ABCB1 haplotypes .
24042126	0	tacrolimus	63,73	ABCB1	14,19	tacrolimus	ABCB1	MESH:D016559	5243	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY polymorphism|nmod|pharmacokinetics polymorphism|compound|END_ENTITY	The effect of ABCB1 C3435T polymorphism on pharmacokinetics of tacrolimus in liver transplantation : a meta-analysis .
22504573	0	tacrolimus	58,68	C3435	36,41	tacrolimus	C3435	MESH:D016559	1039312(Tax:199310)	Chemical	Gene	polymorphism|nmod|START_ENTITY polymorphism|compound|END_ENTITY	Meta-analysis of the effect of MDR1 C3435 polymorphism on tacrolimus pharmacokinetics in renal transplant recipients .
11821750	0	tacrolimus	43,53	CYP2C19	117,124	tacrolimus	CYP2C19	MESH:D016559	1557	Chemical	Gene	concentration|amod|START_ENTITY Effects|nmod|concentration Effects|dep|case case|nmod|recipient recipient|nmod|mutation mutation|compound|END_ENTITY	Effects of lansoprazole and rabeprazole on tacrolimus blood concentration : case of a renal transplant recipient with CYP2C19 gene mutation .
12431607	0	tacrolimus	20,30	CYP2C19	94,101	tacrolimus	CYP2C19	MESH:D016559	1557	Chemical	Gene	interaction|nmod|START_ENTITY inhibitors|nsubj|interaction inhibitors|nmod|mutation mutation|compound|END_ENTITY	Drug interaction of tacrolimus and proton pump inhibitors in renal transplant recipients with CYP2C19 gene mutation .
15285851	0	tacrolimus	42,52	CYP2C19	97,104	tacrolimus	CYP2C19	MESH:D016559	1557	Chemical	Gene	lansoprazole|nmod|START_ENTITY Effect|nmod|lansoprazole pharmacokinetics|nsubj|Effect pharmacokinetics|nmod|mutations mutations|nummod|END_ENTITY	Effect of lansoprazole and rabeprazole on tacrolimus pharmacokinetics in healthy volunteers with CYP2C19 mutations .
17377957	0	tacrolimus	69,79	CYP2C19	95,102	tacrolimus	CYP2C19	MESH:D016559	1557	Chemical	Gene	START_ENTITY|nmod|relation relation|nmod|END_ENTITY	Influence of rabeprazole and lansoprazole on the pharmacokinetics of tacrolimus in relation to CYP2C19 , CYP3A5 and MDR1 polymorphisms in renal transplant recipients .
19139162	0	tacrolimus	66,76	CYP2C19	21,28	tacrolimus	CYP2C19	MESH:D016559	1557	Chemical	Gene	interaction|nmod|START_ENTITY genotypes|nmod|interaction Impact|amod|genotypes Impact|nmod|END_ENTITY	Impact of intestinal CYP2C19 genotypes on the interaction between tacrolimus and omeprazole , but not lansoprazole , in adult living-donor liver transplant patients .
22106961	0	tacrolimus	93,103	CYP3A	60,65	tacrolimus	CYP3A	MESH:D016559	1576	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|compound|END_ENTITY	Effect of voriconazole and other azole antifungal agents on CYP3A activity and metabolism of tacrolimus in human liver microsomes .
15307840	0	tacrolimus	98,108	CYP3A4	0,6	tacrolimus	CYP3A4	MESH:D016559	1576	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	CYP3A4 and P-glycoprotein activity in healthy controls and transplant patients on cyclosporin vs. tacrolimus vs. sirolimus .
21916909	0	tacrolimus	85,95	CYP3A4	22,28	tacrolimus	CYP3A4	MESH:D016559	1576	Chemical	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of ABCB1 , CYP3A4 * 18B and CYP3A5 * 3 genotypes with the pharmacokinetics of tacrolimus in healthy Chinese subjects : a population pharmacokinetic analysis .
24052064	0	tacrolimus	30,40	CYP3A4	10,16	tacrolimus	CYP3A4	MESH:D016559	1576	Chemical	Gene	Impact|nmod|START_ENTITY Impact|nmod|END_ENTITY	Impact of CYP3A4 * 22 allele on tacrolimus pharmacokinetics in early period after renal transplantation : toward updated genotype-based dosage guidelines .
14747421	11	tacrolimus	1771,1781	CYP3A5	1726,1732	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	dose|compound|START_ENTITY required|dobj|dose required|nsubj|genotypes genotypes|compound|END_ENTITY	CYP3A5 expressor genotypes required a larger tacrolimus dose to achieve the same blood levels than the CYP3A5 nonexpressors at all time points during the first posttransplant year .
15226679	0	tacrolimus	75,85	CYP3A5	0,6	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	ratio|nmod|START_ENTITY reduces|dobj|ratio reduces|dep|END_ENTITY	CYP3A5 * 1-carrying graft liver reduces the concentration/oral dose ratio of tacrolimus in recipients of living-donor liver transplantation .
15502717	0	tacrolimus	78,88	CYP3A5	13,19	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY polymorphisms|nmod|pharmacokinetics polymorphisms|nsubj|Influence Influence|nmod|END_ENTITY	Influence of CYP3A5 and MDR1 -LRB- ABCB1 -RRB- polymorphisms on the pharmacokinetics of tacrolimus in renal transplant recipients .
15729180	0	tacrolimus	78,88	CYP3A5	33,39	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	concentrations|amod|START_ENTITY predicts|dobj|concentrations predicts|dep|END_ENTITY	Tacrolimus pharmacogenetics : the CYP3A5 * 1 allele predicts low dose-normalized tacrolimus blood concentrations in whites and South Asians .
15919447	0	tacrolimus	81,91	CYP3A5	10,16	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY C3435T|nmod|pharmacokinetics C3435T|nsubj|Impact Impact|nmod|END_ENTITY	Impact of CYP3A5 and MDR1 -LRB- ABCB1 -RRB- C3435T polymorphisms on the pharmacokinetics of tacrolimus in renal transplant recipients .
15951320	0	tacrolimus	60,70	CYP3A5	16,22	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	clearance|nmod|START_ENTITY Contribution|nmod|clearance Contribution|nmod|END_ENTITY	Contribution of CYP3A5 to the in vitro hepatic clearance of tacrolimus .
16146556	0	tacrolimus	46,56	CYP3A5	13,19	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	concentration|amod|START_ENTITY polymorphisms|nmod|concentration polymorphisms|nsubj|Influence Influence|nmod|END_ENTITY	Influence of CYP3A5 and MDR1 polymorphisms on tacrolimus concentration in the early stage after renal transplantation .
16424824	0	tacrolimus	45,55	CYP3A5	21,27	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of intestinal CYP3A5 on postoperative tacrolimus trough levels in living-donor liver transplant recipients .
16424824	9	tacrolimus	1492,1502	CYP3A5	1439,1445	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	dose|nmod|START_ENTITY require|dobj|dose tended|xcomp|require tended|nsubj|Patients Patients|nmod|END_ENTITY	Patients with the intestinal CYP3A5 * 1 genotype tended to require a higher dose of tacrolimus compared to the other group with the same hepatic CYP3A5 genotype .
16431292	0	tacrolimus	37,47	CYP3A5	97,103	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	START_ENTITY|acl|dosing dosing|nmod|patients patients|acl:relcl|END_ENTITY	Impact of ABCB1 -LRB- MDR1 -RRB- haplotypes on tacrolimus dosing in adult lung transplant patients who are CYP3A5 * 3 / * 3 non-expressors .
16501005	0	tacrolimus	33,43	CYP3A5	10,16	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	clearance|amod|START_ENTITY polymorphism|nmod|clearance polymorphism|nsubj|Effect Effect|nmod|END_ENTITY	Effect of CYP3A5 polymorphism on tacrolimus metabolic clearance in vitro .
17192769	0	tacrolimus	60,70	CYP3A5	0,6	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY influences|dobj|pharmacokinetics influences|nsubj|markedly markedly|compound|END_ENTITY	CYP3A5 genotype markedly influences the pharmacokinetics of tacrolimus and sirolimus in kidney transplant recipients .
17391324	0	tacrolimus	82,92	CYP3A5	17,23	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY Influence|nmod|pharmacokinetics Influence|nmod|END_ENTITY	Influence of the CYP3A5 and MDR1 genetic polymorphisms on the pharmacokinetics of tacrolimus in healthy Korean subjects .
17430486	0	tacrolimus	36,46	CYP3A5	17,23	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	genotype|nmod|START_ENTITY genotype|compound|END_ENTITY	Influence of the CYP3A5 genotype on tacrolimus pharmacokinetics and pharmacodynamics in young kidney transplant recipients .
17495880	0	tacrolimus	83,93	CYP3A5	0,6	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	disposition|compound|START_ENTITY determine|dobj|disposition determine|nsubj|END_ENTITY	CYP3A5 and CYP3A4 but not MDR1 single-nucleotide polymorphisms determine long-term tacrolimus disposition and drug-related nephrotoxicity in renal recipients .
18443548	0	tacrolimus	62,72	CYP3A5	14,20	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY polymorphisms|nmod|pharmacokinetics polymorphisms|nsubj|effect effect|nmod|END_ENTITY	The effect of CYP3A5 polymorphisms on the pharmacokinetics of tacrolimus in adolescent kidney transplant recipients .
18704002	0	tacrolimus	88,98	CYP3A5	11,17	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	interactions|nmod|START_ENTITY polymorphisms|nmod|interactions single|dobj|polymorphisms single|nsubj|Effects Effects|nmod|END_ENTITY	Effects of CYP3A5 and MDR1 single nucleotide polymorphisms on drug interactions between tacrolimus and fluconazole in renal allograft recipients .
19010156	0	tacrolimus	88,98	CYP3A5	54,60	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	START_ENTITY|nsubj|relevance relevance|nmod|polymorphisms polymorphisms|nmod|genes genes|compound|END_ENTITY	Clinical relevance and prevalence of polymorphisms in CYP3A5 and MDR1 genes that encode tacrolimus biotransformation enzymes in liver transplant recipients .
19067682	0	tacrolimus	44,54	CYP3A5	13,19	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	requirements|amod|START_ENTITY Influence|nmod|requirements Influence|nmod|polymorphism polymorphism|compound|END_ENTITY	Influence of CYP3A5 genetic polymorphism on tacrolimus daily dose requirements and acute rejection in renal graft recipients .
19125240	0	tacrolimus	33,43	CYP3A5	0,6	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	concentrations|amod|START_ENTITY associated|nmod|concentrations allele|acl|associated *|dobj|allele *|nsubj|END_ENTITY	CYP3A5 * 1 allele associated with tacrolimus trough concentrations but not subclinical acute rejection or chronic_allograft_nephropathy in Japanese renal transplant recipients .
19289993	0	tacrolimus	66,76	CYP3A5	14,20	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	requirements|amod|START_ENTITY single|nmod|requirements single|nsubj|effect effect|nmod|END_ENTITY	The effect of CYP3A5 and ABCB1 single nucleotide polymorphisms on tacrolimus dose requirements in Caucasian liver transplant patients .
19376366	0	tacrolimus	92,102	CYP3A5	25,31	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	levels|nmod|START_ENTITY polymorphisms|nmod|levels polymorphisms|nmod|genes genes|compound|END_ENTITY	Genetic polymorphisms in CYP3A5 and MDR1 genes and their correlations with plasma levels of tacrolimus and cyclosporine in renal transplant recipients .
19384264	0	tacrolimus	59,69	CYP3A5	0,6	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	concentration|nmod|START_ENTITY influences|dobj|concentration influences|csubj|END_ENTITY	CYP3A5 * 1 / * 3 genotype influences the blood concentration of tacrolimus in response to metabolic inhibition by ketoconazole .
19545678	0	tacrolimus	69,79	CYP3A5	10,16	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	treated|nmod|START_ENTITY recipients|acl|treated genotype|nmod|recipients genotype|nsubj|Effect Effect|nmod|END_ENTITY	Effect of CYP3A5 genotype on renal allograft recipients treated with tacrolimus .
20010459	0	tacrolimus	80,90	CYP3A5	0,6	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	variation|nmod|START_ENTITY associated|nmod|variation associated|nsubj|* *|compound|END_ENTITY	CYP3A5 * 3 genotype associated with intrasubject pharmacokinetic variation toward tacrolimus in bioequivalence study .
20041908	0	tacrolimus	53,63	CYP3A5	12,18	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	requirements|nmod|START_ENTITY genotypes|nmod|requirements genotypes|nsubj|role role|nmod|END_ENTITY	The role of CYP3A5 genotypes in dose requirements of tacrolimus and everolimus after heart transplantation .
20415563	0	tacrolimus	41,51	CYP3A5	0,6	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	concentrations|amod|START_ENTITY influence|dobj|concentrations influence|nsubj|polymorphisms polymorphisms|compound|END_ENTITY	CYP3A5 and ABCB1 polymorphisms influence tacrolimus concentrations in peripheral blood mononuclear cells after renal transplantation .
20485320	0	tacrolimus	7,17	CYP3A5	27,33	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	START_ENTITY|acl|based based|nmod|genotype genotype|compound|END_ENTITY	Dosing tacrolimus based on CYP3A5 genotype : will it improve clinical outcome ?
20514078	0	tacrolimus	44,54	CYP3A5	70,76	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	START_ENTITY|nmod|relation relation|nmod|END_ENTITY	Effects of diltiazem on pharmacokinetics of tacrolimus in relation to CYP3A5 genotype status in renal recipients : from retrospective to prospective .
20568249	0	tacrolimus	55,65	CYP3A5	121,127	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY itraconazole|nmod|pharmacokinetics Effect|nmod|itraconazole stem|nsubj|Effect stem|dobj|recipient recipient|nmod|END_ENTITY	Effect of oral itraconazole on the pharmacokinetics of tacrolimus in a hematopoietic stem cell transplant recipient with CYP3A5 * 3 / * 3 .
20818295	0	tacrolimus	91,101	CYP3A5	27,33	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	formulations|amod|START_ENTITY concentrations|nmod|formulations *|nmod|concentrations *|nsubj|impact impact|nmod|END_ENTITY	Differential impact of the CYP3A5 * 1 and CYP3A5 * 3 alleles on pre-dose concentrations of two tacrolimus formulations .
20864901	0	tacrolimus	87,97	CYP3A5	37,43	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	clearance|nmod|START_ENTITY genotype|nmod|clearance genotype|nsubj|review review|nmod|effect effect|nmod|END_ENTITY	A systematic review of the effect of CYP3A5 genotype on the apparent oral clearance of tacrolimus in renal transplant recipients .
21094796	0	tacrolimus	77,87	CYP3A5	13,19	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY polymorphisms|nmod|pharmacokinetics polymorphisms|nsubj|Influence Influence|nmod|END_ENTITY	Influence of CYP3A5 and MDR1 -LRB- ABCB1 -RRB- polymorphisms on the pharmacokinetics of tacrolimus in Chinese_renal_transplant_recipients .
21094797	0	tacrolimus	61,71	CYP3A5	9,15	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	dosages|nmod|START_ENTITY determining|dobj|dosages genotyping|advcl|determining Value|acl|genotyping Value|nmod|END_ENTITY	Value of CYP3A5 genotyping on determining initial dosages of tacrolimus for Chinese renal transplant recipients .
21528942	0	tacrolimus	139,149	CYP3A5	34,40	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	formulation|nmod|START_ENTITY Influence|nmod|formulation Influence|nmod|polymorphism polymorphism|compound|END_ENTITY	Influence of cytochrome_P450_3A5 -LRB- CYP3A5 -RRB- genetic polymorphism on the pharmacokinetics of the prolonged-release , once-daily formulation of tacrolimus in stable renal transplant recipients .
21566507	0	tacrolimus	66,76	CYP3A5	0,6	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	clearance|amod|START_ENTITY variability|nmod|clearance related|nmod|variability related|nsubjpass|genotype genotype|compound|END_ENTITY	CYP3A5 genotype is not related to the intrapatient variability of tacrolimus clearance .
21635144	0	tacrolimus	82,92	CYP3A5	62,68	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	genotypes|nmod|START_ENTITY genotypes|nummod|END_ENTITY	Impact of the CYP3A4 * 1G polymorphism and its combination with CYP3A5 genotypes on tacrolimus pharmacokinetics in renal transplant patients .
21711429	0	tacrolimus	36,46	CYP3A5	13,19	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	doses|amod|START_ENTITY polymorphism|nmod|doses polymorphism|compound|END_ENTITY	Influence of CYP3A5 polymorphism on tacrolimus maintenance doses and serum levels after renal transplantation : age dependency and pharmacological interaction with steroids .
21886016	0	tacrolimus	6,16	CYP3A5	74,80	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	START_ENTITY|nmod|nonexpressers nonexpressers|nummod|END_ENTITY	Lower tacrolimus daily dose requirements and acute rejection rates in the CYP3A5 nonexpressers than expressers .
22210422	0	tacrolimus	65,75	CYP3A5	10,16	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	recipients|nmod|START_ENTITY genotype|nmod|recipients genotype|nummod|END_ENTITY	Impact of CYP3A5 genotype of recipients as well as donors on the tacrolimus pharmacokinetics and infectious_complications after living-donor liver transplantation for Japanese adult recipients .
22309416	0	tacrolimus	20,30	CYP3A5	74,80	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	concentration|amod|START_ENTITY concentration|nmod|END_ENTITY	Association between tacrolimus concentration and genetic polymorphisms of CYP3A5 and ABCB1 during the early stage after liver transplant in an Iranian population .
22491658	0	tacrolimus	8,18	CYP3A5	31,37	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	toxicity|amod|START_ENTITY toxicity|nmod|nonexpressors nonexpressors|nummod|END_ENTITY	Risk of tacrolimus toxicity in CYP3A5 nonexpressors treated with intravenous nicardipine after kidney transplantation .
22660440	0	tacrolimus	18,28	CYP3A5	80,86	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	pharmacokinetic|amod|START_ENTITY Prediction|nmod|pharmacokinetic parameters|nsubj|Prediction parameters|nmod|genotype genotype|nummod|END_ENTITY	Prediction of the tacrolimus population pharmacokinetic parameters according to CYP3A5 genotype and clinical factors using NONMEM in adult kidney transplant recipients .
22704849	0	tacrolimus	84,94	CYP3A5	0,6	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	dosing|amod|START_ENTITY polymorphism|nmod|dosing polymorphism|nsubj|END_ENTITY	CYP3A5 polymorphism in Mexican renal transplant recipients and its association with tacrolimus dosing .
22889968	0	tacrolimus	61,71	CYP3A5	10,16	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	cross-reactivity|nmod|START_ENTITY polymorphism|nmod|cross-reactivity polymorphism|nummod|END_ENTITY	Impact of CYP3A5 genetic polymorphism on cross-reactivity in tacrolimus chemiluminescent immunoassay in kidney transplant recipients .
22992768	0	tacrolimus	67,77	CYP3A5	47,53	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	genotypes|nmod|START_ENTITY genotypes|compound|END_ENTITY	Combinational effect of intestinal and hepatic CYP3A5 genotypes on tacrolimus pharmacokinetics in recipients of living donor liver transplantation .
22993851	0	tacrolimus	81,91	CYP3A5	23,29	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	dosage|nmod|START_ENTITY polymorphism|nmod|dosage *|dep|polymorphism *|nummod|END_ENTITY	-LSB- Effect of CYP3A4 * 18B , CYP3A5 * 3 gene polymorphism on dosage and concentration of tacrolimus in renal transplant patients -RSB- .
23146479	0	tacrolimus	65,75	CYP3A5	10,16	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	dose|amod|START_ENTITY determinants|nmod|dose genotypes|nmod|determinants genotypes|nsubj|Effect Effect|nmod|END_ENTITY	Effect of CYP3A5 , CYP3A4 , and ABCB1 genotypes as determinants of tacrolimus dose and clinical outcomes after heart transplantation .
23438946	0	tacrolimus	76,86	CYP3A5	10,16	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	interaction|nmod|START_ENTITY polymorphism|nmod|interaction Effect|dep|polymorphism Effect|nmod|END_ENTITY	Effect of CYP3A5 * 3 polymorphism on pharmacokinetic drug interaction between tacrolimus and amlodipine .
23666583	0	tacrolimus	61,71	CYP3A5	0,6	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	clearance|amod|START_ENTITY variability|nmod|clearance impact|nmod|variability had|dobj|impact had|nsubj|genotype genotype|compound|END_ENTITY	CYP3A5 genotype had no impact on intrapatient variability of tacrolimus clearance in renal transplant recipients .
23900887	0	tacrolimus	72,82	CYP3A5	30,36	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	requirements|amod|START_ENTITY Impact|nmod|requirements Impact|nmod|donor donor|nummod|END_ENTITY	Impact of donor and recipient CYP3A5 and ABCB1 genetic polymorphisms on tacrolimus dosage requirements and rejection in Caucasian Spanish liver transplant patients .
23955548	0	tacrolimus	68,78	CYP3A5	20,26	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	genotypes|nmod|START_ENTITY genotypes|nsubj|Association Association|nmod|END_ENTITY	Association between CYP3A5 genotypes in graft liver and increase in tacrolimus biotransformation from steroid treatment in living-donor liver transplant patients .
23990505	0	tacrolimus	112,122	CYP3A5	47,53	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	associated|nmod|START_ENTITY events|acl|associated polymorphisms|nmod|events polymorphisms|nsubj|model model|acl|evaluate evaluate|dobj|effect effect|nmod|END_ENTITY	A Markov chain model to evaluate the effect of CYP3A5 and ABCB1 polymorphisms on adverse events associated with tacrolimus in pediatric renal transplantation .
24024898	0	tacrolimus	29,39	CYP3A5	10,16	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	genotype|nmod|START_ENTITY genotype|nummod|END_ENTITY	Impact of CYP3A5 genotype on tacrolimus versus midazolam clearance in renal transplant recipients : new insights in CYP3A5-mediated drug metabolism .
24033383	0	tacrolimus	137,147	CYP3A5	10,16	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|Impact Impact|nmod|polymorphisms polymorphisms|nummod|END_ENTITY	Impact of CYP3A5 genetic polymorphisms on the pharmacokinetics and short-term remission in patients with ulcerative_colitis treated with tacrolimus .
24059111	0	tacrolimus	86,96	CYP3A5	16,22	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	concentration|nmod|START_ENTITY polymorphisms|nmod|concentration polymorphisms|nummod|END_ENTITY	-LSB- Association of CYP3A5 and MDR1 genetic polymorphisms with the blood concentration of tacrolimus in Chinese liver and renal transplant recipients -RSB- .
24089074	0	tacrolimus	31,41	CYP3A5	89,95	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY pharmacokinetics|dep|impact impact|nmod|genotype genotype|nummod|END_ENTITY	Population pharmacokinetics of tacrolimus in adult kidney transplant patients : impact of CYP3A5 genotype on starting dose .
24118301	0	tacrolimus	86,96	CYP3A5	13,19	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	dosing|nmod|START_ENTITY improves|dobj|dosing improves|nsubj|Inclusion Inclusion|nmod|END_ENTITY	Inclusion of CYP3A5 genotyping in a nonparametric population model improves dosing of tacrolimus early after transplantation .
24120259	0	tacrolimus	13,23	CYP3A5	44,50	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	doses|compound|START_ENTITY determined|nsubj|doses determined|nmod|genotype genotype|compound|END_ENTITY	Personalized tacrolimus doses determined by CYP3A5 genotype for induction and maintenance phases of kidney transplantation .
24231473	0	tacrolimus	47,57	CYP3A5	14,20	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	requirements|amod|START_ENTITY polymorphisms|nmod|requirements polymorphisms|nsubj|impact impact|nmod|END_ENTITY	The impact of CYP3A5 and MDR1 polymorphisms on tacrolimus dosage requirements and trough concentrations in pediatric renal transplant recipients .
24352002	0	tacrolimus	79,89	CYP3A5	32,38	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	polymorphism|nmod|START_ENTITY polymorphism|compound|END_ENTITY	Significant association between CYP3A5 polymorphism and blood concentration of tacrolimus in patients with connective_tissue_diseases .
24383873	0	tacrolimus	74,84	CYP3A5	22,28	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	levels|nmod|START_ENTITY predicting|dobj|levels Pharmacogenotyping|acl|predicting Pharmacogenotyping|nmod|END_ENTITY	Pharmacogenotyping of CYP3A5 in predicting dose-adjusted trough levels of tacrolimus among Malaysian kidney-transplant patients .
24438215	0	tacrolimus	24,34	CYP3A5	0,6	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	pharmacokinetics|amod|START_ENTITY affect|dobj|pharmacokinetics affect|nsubj|genotypes genotypes|compound|END_ENTITY	CYP3A5 genotypes affect tacrolimus pharmacokinetics and infectious_complications in Chinese pediatric liver transplant patients .
24444408	0	tacrolimus	54,64	CYP3A5	0,6	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	concentrations|amod|START_ENTITY affect|dobj|concentrations affect|nsubj|END_ENTITY	CYP3A5 and CYP3A4 , but not ABCB1 polymorphisms affect tacrolimus dose-adjusted trough concentrations in kidney transplant recipients .
24465960	0	tacrolimus	75,85	CYP3A5	14,20	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	metabolism|amod|START_ENTITY Impact|nmod|metabolism Impact|nmod|polymorphisms polymorphisms|compound|END_ENTITY	Impact of the CYP3A5 , CYP3A4 , COMT , IL-10 and POR genetic polymorphisms on tacrolimus metabolism in Chinese renal transplant recipients .
24528196	0	tacrolimus	55,65	CYP3A5	16,22	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	diplotype|xcomp|START_ENTITY diplotype|nsubj|Relationship Relationship|nmod|genotype genotype|compound|END_ENTITY	Relationship of CYP3A5 genotype and ABCB1 diplotype to tacrolimus disposition in Brazilian kidney transplant patients .
24739669	0	tacrolimus	68,78	CYP3A5	0,6	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	dose|nmod|START_ENTITY influence|dobj|dose influence|nsubj|3 3|compound|END_ENTITY	CYP3A5 * 3 and POR * 28 genetic variants influence the required dose of tacrolimus in heart transplant recipients .
24875272	0	tacrolimus	51,61	CYP3A5	10,16	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|genotype genotype|nummod|END_ENTITY	Effect of CYP3A5 genotype , steroids , and azoles on tacrolimus in a pediatric renal transplant population .
25201288	0	tacrolimus	64,74	CYP3A5	10,16	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	treated|nmod|START_ENTITY recipients|acl|treated Effect|nmod|recipients Effect|nmod|END_ENTITY	Effect of CYP3A5 * 3 on kidney transplant recipients treated with tacrolimus : a systematic review and meta-analysis of observational studies .
25322286	0	tacrolimus	118,128	CYP3A5	20,26	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	polymorphisms|nmod|START_ENTITY exposure|dep|polymorphisms 28|dep|exposure *|dobj|28 *|nmod|effects effects|nmod|END_ENTITY	Combined effects of CYP3A5 * 1 , POR * 28 , and CYP3A4 * 22 single nucleotide polymorphisms on early concentration-controlled tacrolimus exposure in de-novo renal recipients .
25846845	0	tacrolimus	39,49	CYP3A5	107,113	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	analysis|nmod|START_ENTITY analysis|dep|role role|nmod|genotype genotype|compound|END_ENTITY	Population pharmacokinetic analysis of tacrolimus in Mexican paediatric renal transplant patients : role of CYP3A5 genotype and formulation .
26176181	0	tacrolimus	33,43	CYP3A5	13,19	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	requirement|amod|START_ENTITY genotypes|nmod|requirement genotypes|nummod|END_ENTITY	Influence of CYP3A5 genotypes on tacrolimus dose requirement : age and its pharmacological interaction with ABCB1 genetics in the Chinese paediatric liver transplantation .
26177012	0	tacrolimus	57,67	CYP3A5	10,16	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	rejection|amod|START_ENTITY pharmacokinetics|nmod|rejection polymorphism|nmod|pharmacokinetics polymorphism|compound|END_ENTITY	Effect of CYP3A5 polymorphism on the pharmacokinetics of tacrolimus and acute rejection in renal transplant recipients : experience at a single centre .
26177348	0	tacrolimus	14,24	CYP3A5	46,52	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|expressing expressing|compound|END_ENTITY	Comparison of tacrolimus and cyclosporin_A in CYP3A5 expressing Chinese de novo kidney transplant recipients : a 2-year prospective study .
26184414	0	tacrolimus	68,78	CYP3A5	10,16	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	interaction|nmod|START_ENTITY polymorphisms|nmod|interaction polymorphisms|nsubj|Effect Effect|nmod|END_ENTITY	Effect of CYP3A5 and ABCB1 polymorphisms on the interaction between tacrolimus and itraconazole in patients with connective_tissue_disease .
26543771	0	tacrolimus	36,46	CYP3A5	0,6	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	pharmacokinetics|nsubj|START_ENTITY genotype|ccomp|pharmacokinetics genotype|nsubj|END_ENTITY	CYP3A5 and ABCB1 genotype influence tacrolimus and sirolimus pharmacokinetics in renal transplant recipients .
26634478	0	tacrolimus	39,49	CYP3A5	10,16	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	polymorphisms|nmod|START_ENTITY polymorphisms|nummod|END_ENTITY	Effect of CYP3A5 gene polymorphisms on tacrolimus concentration/dosage ratio in adult liver transplant patients .
26635230	0	tacrolimus	71,81	CYP3A5	10,16	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	polymorphism|nmod|START_ENTITY polymorphism|compound|END_ENTITY	Impact of CYP3A5 polymorphism on trough concentrations and outcomes of tacrolimus minimization during the early period after kidney transplantation .
26714287	0	tacrolimus	100,110	CYP3A5	56,62	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	genotype-based|nmod|START_ENTITY END_ENTITY|acl|genotype-based	A Randomized controlled trial comparing the efficacy of CYP3A5 genotype-based with bodyweight-based tacrolimus dosing after living donor kidney transplantation .
26823971	0	tacrolimus	103,113	CYP3A5	12,18	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	twice-daily|nmod|START_ENTITY conversion|nmod|twice-daily polymorphism|nmod|conversion polymorphism|nummod|END_ENTITY	The role of CYP3A5 polymorphism and dose adjustments following conversion of twice-daily to once-daily tacrolimus in renal transplant recipients .
26856709	0	tacrolimus	71,81	CYP3A5	10,16	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	dose|nmod|START_ENTITY polymorphisms|nmod|dose polymorphisms|nsubj|Impact Impact|nmod|gene gene|compound|END_ENTITY	Impact of CYP3A5 and MDR-1 gene polymorphisms on the dose and level of tacrolimus among living-donor liver transplanted patients : single center experience .
26990694	0	tacrolimus	51,61	CYP3A5	72,78	tacrolimus	CYP3A5	MESH:D016559	1577	Chemical	Gene	START_ENTITY|acl|dosing dosing|nmod|END_ENTITY	Long-term clinical impact of adaptation of initial tacrolimus dosing to CYP3A5 genotype .
21227887	0	tacrolimus	11,21	IFN-y	25,30	tacrolimus	IFN-y	MESH:D016559	3458	Chemical	Gene	START_ENTITY|nmod|signaling signaling|compound|END_ENTITY	Effects of tacrolimus on IFN-y signaling in keratinocytes : possible mechanisms by which tacrolimus affects IFN-y-dependent skin_inflammation .
20145524	0	tacrolimus	72,82	Insulin	0,7	tacrolimus	Insulin	MESH:D016559	3630	Chemical	Gene	immunosuppression|amod|START_ENTITY maintained|nmod|immunosuppression maintained|nsubj|indexes indexes|amod|END_ENTITY	Insulin resistance indexes in renal transplant recipients maintained on tacrolimus immunosuppression .
22897149	0	tacrolimus	43,53	Insulin	0,7	tacrolimus	Insulin	MESH:D016559	3630	Chemical	Gene	independence|nmod|START_ENTITY independence|compound|END_ENTITY	Insulin independence after conversion from tacrolimus to cyclosporine in islet transplantation .
16409819	0	tacrolimus	72,82	MDR1	22,26	tacrolimus	MDR1	MESH:D016559	5243	Chemical	Gene	polymorphism|nmod|START_ENTITY polymorphism|compound|END_ENTITY	-LSB- Relationship between MDR1 gene polymorphism and blood concentration of tacrolimus in renal transplant patients -RSB- .
22504573	0	tacrolimus	58,68	MDR1	31,35	tacrolimus	MDR1	MESH:D016559	5243	Chemical	Gene	polymorphism|nmod|START_ENTITY polymorphism|compound|END_ENTITY	Meta-analysis of the effect of MDR1 C3435 polymorphism on tacrolimus pharmacokinetics in renal transplant recipients .
24351870	0	tacrolimus	76,86	NR1I3	46,51	tacrolimus	NR1I3	MESH:D016559	9970	Chemical	Gene	polymorphisms|nmod|START_ENTITY polymorphisms|nummod|END_ENTITY	Association of hemoglobin levels , CYP3A5 , and NR1I3 gene polymorphisms with tacrolimus pharmacokinetics in liver transplant patients .
10751036	0	tacrolimus	93,103	P-glycoprotein	27,41	tacrolimus	P-glycoprotein	MESH:D016559	67078(Tax:10090)	Chemical	Gene	substrate|appos|START_ENTITY absorption|nmod|substrate lack|nmod|absorption lack|nmod|effect effect|nmod|END_ENTITY	Apparent lack of effect of P-glycoprotein on the gastrointestinal absorption of a substrate , tacrolimus , in normal mice .
10945321	0	tacrolimus	45,55	P-glycoprotein	21,35	tacrolimus	P-glycoprotein	MESH:D016559	5243	Chemical	Gene	level|amod|START_ENTITY END_ENTITY|nmod|level	Effect of intestinal P-glycoprotein on daily tacrolimus trough level in a living-donor small bowel recipient .
11303042	0	tacrolimus	113,123	P-glycoprotein	16,30	tacrolimus	P-glycoprotein	MESH:D016559	5243	Chemical	Gene	bioavailability|nmod|START_ENTITY Contribution|nmod|bioavailability Contribution|nmod|END_ENTITY	Contribution of P-glycoprotein to the enhancing effects of dimethyl-beta-cyclodextrin on oral bioavailability of tacrolimus .
11920757	0	tacrolimus	128,138	P-glycoprotein	78,92	tacrolimus	P-glycoprotein	MESH:D016559	287115(Tax:10116)	Chemical	Gene	permeability|nmod|START_ENTITY efflux|nmod|permeability efflux|amod|END_ENTITY	Tacrolimus is a class II low-solubility high-permeability drug : the effect of P-glycoprotein efflux on regional permeability of tacrolimus in rats .
15888045	0	tacrolimus	68,78	P-glycoprotein	24,38	tacrolimus	P-glycoprotein	MESH:D016559	5243	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Cytochrome P450 3A4 and P-glycoprotein activity and assimilation of tacrolimus in transplant patients with persistent diarrhea .
16416180	0	tacrolimus	29,39	P-glycoprotein	102,116	tacrolimus	P-glycoprotein	MESH:D016559	5243	Chemical	Gene	requirement|nmod|START_ENTITY related|nsubjpass|requirement related|nmod|content content|amod|END_ENTITY	A higher dose requirement of tacrolimus in active Crohn 's _ disease may be related to a high intestinal P-glycoprotein content .
16507509	0	tacrolimus	52,62	P-glycoprotein	8,22	tacrolimus	P-glycoprotein	MESH:D016559	287115(Tax:10116)	Chemical	Gene	metabolism|nmod|START_ENTITY Role|nmod|metabolism Role|nmod|END_ENTITY	Role of P-glycoprotein in the hepatic metabolism of tacrolimus .
17268068	0	tacrolimus	105,115	P-glycoprotein	0,14	tacrolimus	P-glycoprotein	MESH:D016559	5243	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|function function|amod|END_ENTITY	P-glycoprotein function in peripheral blood mononuclear cells of myasthenia_gravis patients treated with tacrolimus .
18827354	0	tacrolimus	10,20	P-glycoprotein	51,65	tacrolimus	P-glycoprotein	MESH:D016559	5243	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|proteins proteins|amod|END_ENTITY	Effect of tacrolimus on activity and expression of P-glycoprotein and ATP-binding cassette transporter A5 -LRB- ABCA5 -RRB- proteins in hematoencephalic barrier cells .
8787547	0	tacrolimus	143,153	P53	13,16	tacrolimus	P53	MESH:D016559	7157	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Antioncogene P53 and mitogenic cytokine interleukin-8 aberrantly expressed in psoriatic skin are inversely regulated by the antipsoriatic drug tacrolimus -LRB- FK506 -RRB- .
11465431	0	tacrolimus	11,21	PEPT1	63,68	tacrolimus	PEPT1	MESH:D016559	6564	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of tacrolimus and cyclosporin_A on peptide transporter PEPT1 in Caco-2 cells .
19149927	0	tacrolimus	11,21	growth-associated_protein-43	25,53	tacrolimus	growth-associated protein-43	MESH:D016559	29423(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effect of tacrolimus on growth-associated_protein-43 expression in the hippocampus of neonatal rats with hypoxic-ischemic_brain_damage -RSB- .
8981925	0	tacrolimus	11,21	insulin	39,46	tacrolimus	insulin	MESH:D016559	3630	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of tacrolimus -LRB- FK506 -RRB- on human insulin gene expression , insulin mRNA levels , and insulin secretion in HIT-T15 cells .
15802130	0	tacrolimus	37,47	surfactant_protein_A	59,79	tacrolimus	surfactant protein A	MESH:D016559	653509	Chemical	Gene	START_ENTITY|xcomp|binding binding|nmod|END_ENTITY	Equilibrium studies of a fluorescent tacrolimus binding to surfactant_protein_A .
15316360	0	tacrolimus	24,34	transforming_growth_factor-beta1	107,139	tacrolimus	transforming growth factor-beta1	MESH:D016559	59086(Tax:10116)	Chemical	Gene	nephrotoxicity|nmod|START_ENTITY nephrotoxicity|dep|expression expression|nmod|END_ENTITY	Acute nephrotoxicity of tacrolimus and sirolimus in renal isografts : differential intragraft expression of transforming_growth_factor-beta1 and alpha-smooth_muscle_actin .
20073093	0	tacrolimus	8,18	vascular_endothelial_growth_factor	48,82	tacrolimus	vascular endothelial growth factor	MESH:D016559	22339(Tax:10090)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|nmod|END_ENTITY	Topical tacrolimus suppresses the expression of vascular_endothelial_growth_factor and insulin-like_growth_factor-1 in late anagen .
15538396	0	tadalafil	32,41	PDE5	102,106	tadalafil	PDE5	MESH:C429886	8654	Chemical	Gene	selectivity|nmod|START_ENTITY selectivity|nmod|phosphodiesterase_5A1 phosphodiesterase_5A1|appos|END_ENTITY	High biochemical selectivity of tadalafil , sildenafil and vardenafil for human phosphodiesterase_5A1 -LRB- PDE5 -RRB- over PDE11A4 suggests the absence of PDE11A4 cross-reaction in patients .
17107795	0	tadalafil	74,83	PDE5	0,4	tadalafil	PDE5	MESH:C429886	8654	Chemical	Gene	analogues|nmod|START_ENTITY access|nmod|analogues inhibitors|dep|access inhibitors|nummod|END_ENTITY	PDE5 inhibitors : An original access to novel potent arylated analogues of tadalafil .
20704642	0	tadalafil	52,61	PDE5	37,41	tadalafil	PDE5	MESH:C429886	8654	Chemical	Gene	benefit|compound|START_ENTITY benefit|compound|END_ENTITY	Hypogonadal men nonresponders to the PDE5 inhibitor tadalafil benefit from normalization of testosterone levels with a 1 % hydroalcoholic_testosterone_gel in the treatment of erectile_dysfunction -LRB- TADTEST study -RRB- .
21194760	0	tadalafil	105,114	PDE5	84,88	tadalafil	PDE5	MESH:C429886	8654	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Brachial artery flow mediated assessment : a tool to predict the response to chronic PDE5 inhibition with tadalafil in patients with erectile_dysfunction .
21707928	0	tadalafil	111,120	PDE5	172,176	tadalafil	PDE5	MESH:C429886	8654	Chemical	Gene	efficacy|nmod|START_ENTITY assess|dobj|efficacy assess|nmod|men men|acl:relcl|are are|xcomp|ve ve|nmod|END_ENTITY	A randomized , double-blind , placebo-controlled , parallel study to assess the efficacy and safety of once-a-day tadalafil in men with erectile_dysfunction who are na ve to PDE5 inhibitors .
23253640	0	tadalafil	112,121	PDE5	97,101	tadalafil	PDE5	MESH:C429886	8654	Chemical	Gene	therapy|compound|START_ENTITY therapy|nummod|END_ENTITY	Comparison of efficacy and satisfaction profile , between penile prosthesis implantation and oral PDE5 inhibitor tadalafil therapy , in men with nerve-sparing radical prostatectomy erectile_dysfunction .
23841532	0	tadalafil	42,51	PDE5	105,109	tadalafil	PDE5	MESH:C429886	8654	Chemical	Gene	function|nmod|START_ENTITY function|advmod|daily daily|nmod|therapy therapy|compound|END_ENTITY	A return to normal erectile function with tadalafil once daily after an incomplete response to as-needed PDE5 inhibitor therapy .
24666765	0	tadalafil	21,30	PDE5	154,158	tadalafil	PDE5	MESH:C429886	8654	Chemical	Gene	Effect|nmod|START_ENTITY responders|nsubj|Effect responders|nmod|treatment treatment|compound|END_ENTITY	Effect of once-daily tadalafil on confidence and perceived difficulty in performing sexual intercourse in men who were incomplete responders to as-needed PDE5 inhibitor treatment .
16409221	0	tadalafil	47,56	Phosphodiesterase_type_5	0,24	tadalafil	Phosphodiesterase type 5	MESH:C429886	8654	Chemical	Gene	upregulated|nmod|START_ENTITY upregulated|nsubjpass|END_ENTITY	Phosphodiesterase_type_5 is not upregulated by tadalafil in cultures of human penile cells .
18199808	0	tadalafil	81,90	phosphodiesterase-5	42,61	tadalafil	phosphodiesterase-5	MESH:C429886	8654	Chemical	Gene	site|nmod|START_ENTITY site|amod|END_ENTITY	Phosphorylation increases affinity of the phosphodiesterase-5 catalytic site for tadalafil .
20543097	0	tadalafil	42,51	phosphodiesterase-5	12,31	tadalafil	phosphodiesterase-5	MESH:C429886	8654	Chemical	Gene	attenuates|compound|START_ENTITY attenuates|amod|END_ENTITY	Long-acting phosphodiesterase-5 inhibitor tadalafil attenuates doxorubicin-induced cardiomyopathy without interfering with chemotherapeutic effect .
20206015	0	tadalafil	65,74	phosphodiesterase_5	88,107	tadalafil	phosphodiesterase 5	MESH:C429886	8654	Chemical	Gene	analogues|amod|START_ENTITY analogues|nmod|inhibitors inhibitors|amod|END_ENTITY	Synthesis , molecular modeling and biological evaluation of novel tadalafil analogues as phosphodiesterase_5 and colon_tumor cell growth inhibitors , new stereochemical perspective .
21056623	0	tadalafil	40,49	phosphodiesterase_type-5	4,28	tadalafil	phosphodiesterase type-5	MESH:C429886	171115(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	The phosphodiesterase_type-5 inhibitor , tadalafil , improves depressive_symptoms , ameliorates memory_impairment , as well as suppresses apoptosis and enhances cell proliferation in the hippocampus of maternal-separated rat pups .
19036180	0	tadalafil	40,49	phosphodiesterase_type_5	53,77	tadalafil	phosphodiesterase type 5	MESH:C429886	8654	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	EEG_abnormalities during treatment with tadalafil , a phosphodiesterase_type_5 inhibitor .
24988889	0	tadalafil	47,56	phosphodiesterase_type_5	11,35	tadalafil	phosphodiesterase type 5	MESH:C429886	171115(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Effects of phosphodiesterase_type_5 inhibitor , tadalafil , on continence reflex in rats .
25178687	0	tadalafil	49,58	phosphodiesterase_type_5	14,38	tadalafil	phosphodiesterase type 5	MESH:C429886	403825(Tax:9615)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|inhibitor inhibitor|amod|END_ENTITY	Effect of the phosphodiesterase_type_5 inhibitor tadalafil on pulmonary hemodynamics in a canine model of pulmonary_hypertension .
22093625	0	tagalsin	11,19	p53	23,26	tagalsin	p53	null	22060(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	-LSB- Effect of tagalsin on p53 and Bcl-2 expression in hepatoma_H -LRB- 22 -RRB- _ tumor-bearing mice -RSB- .
10748068	1	taipoxin	95,103	NP1	159,162	taipoxin	NP1	MESH:C015523	18164(Tax:10090)	Chemical	Gene	_|nmod|START_ENTITY _|nmod|END_ENTITY	Neuronal_pentraxin _ -LRB- NP -RRB- _ receptor binds to taipoxin and taipoxin-associated_calcium-binding_protein_49 via NP1 and NP2 .
25918798	0	taiwanin_E	96,106	prb	73,76	taiwanin E	prb	null	5925	Chemical	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Anti-proliferation effect on human breast_cancer cells via inhibition of prb phosphorylation by taiwanin_E isolated from Eleutherococcus trifoliatus .
25918798	0	taiwanin_E	96,106	prb	73,76	taiwanin E	prb	null	5925	Chemical	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Anti-proliferation effect on human breast_cancer cells via inhibition of prb phosphorylation by taiwanin_E isolated from Eleutherococcus trifoliatus .
25500058	0	talazoparib	43,54	PARP	24,28	talazoparib	PARP	null	142	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|activity activity|nmod|END_ENTITY	Synergistic activity of PARP inhibition by talazoparib -LRB- BMN 673 -RRB- with temozolomide in pediatric_cancer models in the pediatric preclinical testing program .
26539646	0	talazoparib	74,85	PARP	58,62	talazoparib	PARP	null	142	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	PARP1 expression , activity and ex vivo sensitivity to the PARP inhibitor , talazoparib -LRB- BMN 673 -RRB- , in chronic_lymphocytic_leukaemia .
17542018	0	talinolol	125,134	ABCB1	96,101	talinolol	ABCB1	MESH:C011550	5243	Chemical	Gene	transport|nmod|START_ENTITY mediated|dobj|transport mediated|nsubj|P-glycoprotein P-glycoprotein|appos|END_ENTITY	Grapefruit juice-drug interactions : Grapefruit juice and its components inhibit P-glycoprotein -LRB- ABCB1 -RRB- mediated transport of talinolol in Caco-2 cells .
18195111	0	talinolol	92,101	ABCB1	43,48	talinolol	ABCB1	MESH:C011550	5243	Chemical	Gene	transport|nmod|START_ENTITY Role|nmod|transport Role|nmod|END_ENTITY	Role of the multidrug transporter proteins ABCB1 and ABCC2 in the diaplacental transport of talinolol in the term human placenta .
22725663	0	talinolol	47,56	ABCB1	71,76	talinolol	ABCB1	MESH:C011550	5243	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY Effects|nmod|pharmacokinetics Effects|nmod|human human|nmod|polymorphism polymorphism|compound|END_ENTITY	Effects of curcumin on the pharmacokinetics of talinolol in human with ABCB1 polymorphism .
22339773	0	talinolol	137,146	Abcb1	105,110	talinolol	Abcb1	MESH:C011550	170913(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Effects of rifampicin , dexamethasone , St. John 's Wort and Thyroxine on maternal and foetal expression of Abcb1 and organ distribution of talinolol in pregnant rats .
6548729	0	talinolol	10,19	LCAT	62,66	talinolol	LCAT	MESH:C011550	3931	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	Effect of talinolol and the optical isomers of propranolol on LCAT activity in vitro .
10783825	0	talinolol	72,81	P-glycoprotein	0,14	talinolol	P-glycoprotein	MESH:C011550	5243	Chemical	Gene	bioavailability|nmod|START_ENTITY increases|dobj|bioavailability increases|nsubj|erythromycin erythromycin|amod|END_ENTITY	P-glycoprotein inhibitor erythromycin increases oral bioavailability of talinolol in humans .
10945310	0	talinolol	47,56	P-glycoprotein	97,111	talinolol	P-glycoprotein	MESH:C011550	5243	Chemical	Gene	START_ENTITY|dep|evidence evidence|nmod|involvement involvement|nmod|END_ENTITY	Oral bioavailability of digoxin is enhanced by talinolol : evidence for involvement of intestinal P-glycoprotein .
11061574	0	talinolol	74,83	P-glycoprotein	13,27	talinolol	P-Glycoprotein	MESH:C011550	5243	Chemical	Gene	secretion|nmod|START_ENTITY secretion|amod|END_ENTITY	Induction of P-glycoprotein by rifampin increases intestinal secretion of talinolol in human beings : a new type of drug/drug interaction .
12426521	0	talinolol	118,127	P-glycoprotein	69,83	talinolol	P-glycoprotein	MESH:C011550	5243	Chemical	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	The effects of the human MDR1 genotype on the expression of duodenal P-glycoprotein and disposition of the probe drug talinolol .
12587122	0	talinolol	107,116	P-glycoprotein	40,54	talinolol	P-glycoprotein	MESH:C011550	5243	Chemical	Gene	absorption|nmod|START_ENTITY described|nmod|absorption described|nsubj|Variability Variability|nmod|expression expression|nmod|END_ENTITY	Variability of intestinal expression of P-glycoprotein in healthy volunteers as described by absorption of talinolol from four bioequivalent tablets .
15637528	0	talinolol	53,62	P-glycoprotein	0,14	talinolol	P-glycoprotein	MESH:C011550	5243	Chemical	Gene	absorption|amod|START_ENTITY effect|nmod|absorption END_ENTITY|dep|effect	P-glycoprotein and surfactants : effect on intestinal talinolol absorption .
22983284	0	talinolol	113,122	P-glycoprotein	88,102	talinolol	P-glycoprotein	MESH:C011550	5243	Chemical	Gene	START_ENTITY|nsubj|Lack Lack|nmod|effect effect|nmod|administration administration|nmod|pharmacokinetics pharmacokinetics|nmod|substrate substrate|amod|END_ENTITY	Lack of effect of continuous glycyrrhizin administration on the pharmacokinetics of the P-glycoprotein substrate talinolol in healthy volunteers .
9476144	0	talinolol	133,142	P-glycoprotein	0,14	talinolol	P-glycoprotein	MESH:C011550	287115(Tax:10116)	Chemical	Gene	employing|dobj|START_ENTITY data|acl|employing relevance|nmod|data potential|nmod|relevance evaluation|nmod|potential transporters|dep|evaluation transporters|amod|END_ENTITY	P-glycoprotein transporters and the gastrointestinal tract : evaluation of the potential in vivo relevance of in vitro data employing talinolol as model compound .
20538723	0	talinolol	73,82	p-glycoprotein	8,22	talinolol	p-glycoprotein	MESH:C011550	287115(Tax:10116)	Chemical	Gene	absorption|nmod|START_ENTITY Role|nmod|absorption Role|nmod|END_ENTITY	Role of p-glycoprotein in region-specific gastrointestinal absorption of talinolol in rats .
19214388	0	talosin_A	29,38	NF-kappaB	57,66	talosin A	NF-kappaB	MESH:C516691	18033(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activation activation|amod|END_ENTITY	Anti-inflammatory effects of talosin_A via inhibition of NF-kappaB activation in lipopolysaccharide-stimulated RAW264 .7 cells .
12408927	0	taltirelin	17,27	thyrotropin-releasing_hormone	42,71	taltirelin	thyrotropin-releasing hormone	null	7200	Chemical	Gene	START_ENTITY|appos|analogue analogue|amod|END_ENTITY	Determination of taltirelin , a new stable thyrotropin-releasing_hormone analogue , in human plasma by high-performance liquid chromatography turbo-ionspray ionization tandem mass spectrometry .
16368129	0	taltirelin_hydrate	56,74	thyrotropin-releasing_hormone	78,107	taltirelin hydrate	thyrotropin-releasing hormone	MESH:C065049	25569(Tax:10116)	Chemical	Gene	START_ENTITY|appos|analog analog|amod|END_ENTITY	Lack of behavioral tolerance by repeated treatment with taltirelin_hydrate , a thyrotropin-releasing_hormone analog , in rats .
9608876	0	taltirelin_hydrate	11,29	thyrotropin-releasing_hormone	49,78	taltirelin hydrate	thyrotropin-releasing hormone	MESH:C065049	25569(Tax:10116)	Chemical	Gene	START_ENTITY|appos|analog analog|amod|END_ENTITY	Effects of taltirelin_hydrate -LRB- TA-0910 -RRB- , a novel thyrotropin-releasing_hormone analog , on in vivo dopamine release and turnover in rat brain .
21195063	0	tamarins	74,82	Olfactory_marker_protein	0,24	tamarins	Olfactory marker protein	null	4975	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Olfactory_marker_protein expression in the vomeronasal neuroepithelium of tamarins -LRB- Saguinus spp -RRB- .
17563395	0	tamoxifen	158,167	ARNO	173,177	tamoxifen	ARNO	MESH:D013629	9266	Chemical	Gene	START_ENTITY|dep|Study Study|compound|END_ENTITY	Improved overall survival in postmenopausal women with early breast_cancer after anastrozole initiated after treatment with tamoxifen compared with continued tamoxifen : the ARNO 95 Study .
10713659	0	tamoxifen	17,26	CHOP	30,34	tamoxifen	CHOP	MESH:D013629	1649	Chemical	Gene	Adding|dobj|START_ENTITY Adding|nmod|END_ENTITY	Adding high-dose tamoxifen to CHOP does not influence response or survival in aggressive non-Hodgkin 's _ lymphoma : an interim analysis of a randomized phase III trial .
23838288	0	tamoxifen	57,66	CHOP	88,92	tamoxifen	CHOP	MESH:D013629	1649	Chemical	Gene	START_ENTITY|nmod|up-regulation up-regulation|nmod|END_ENTITY	Inhibition of vacuolar H + ATPase enhances sensitivity to tamoxifen via up-regulation of CHOP in breast_cancer cells .
19019622	0	tamoxifen	39,48	CXCR4	19,24	tamoxifen	CXCR4	MESH:D013629	7852	Chemical	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Down-regulation of CXCR4 expression by tamoxifen is associated with DNA_methyltransferase_3B up-regulation in MCF-7 breast_cancer cells .
12130719	0	tamoxifen	89,98	CYP2A1	34,40	tamoxifen	CYP2A1	MESH:D013629	24894(Tax:10116)	Chemical	Gene	suppression|nmod|START_ENTITY suppression|nmod|expression expression|compound|END_ENTITY	Persistent suppression of hepatic CYP2A1 expression and serum triiodothyronine levels by tamoxifen in intact female rats : dose-response analysis and comparison with 4-hydroxytamoxifen , fulvestrant -LRB- ICI_182 ,780 -RRB- , and 17beta-estradiol-3-benzoate .
12023523	0	tamoxifen	10,19	CYP2B6	66,72	tamoxifen	CYP2B6	MESH:D013629	1555	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|nmod|END_ENTITY	Effect of tamoxifen on the enzymatic activity of human cytochrome CYP2B6 .
10570019	0	tamoxifen	105,114	CYP2C11	30,37	tamoxifen	CYP2C11	MESH:D013629	29277(Tax:10116)	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|END_ENTITY	Modulation of hepatic CYP2A1 , CYP2C11 , and CYP3A9 expression in adult rats by neonatal administration of tamoxifen .
16815318	0	tamoxifen	57,66	CYP2D6	23,29	tamoxifen	CYP2D6	MESH:D013629	1565	Chemical	Gene	metabolism|compound|START_ENTITY genotype|nmod|metabolism genotype|compound|END_ENTITY	Quantitative effect of CYP2D6 genotype and inhibitors on tamoxifen metabolism : implication for optimization of breast_cancer treatment .
25893704	0	tamoxifen	129,138	CYP2D6	108,114	tamoxifen	CYP2D6	MESH:D013629	1565	Chemical	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	CYP3A4 * 22 is related to increased plasma levels of 4-hydroxytamoxifen and partially compensates for reduced CYP2D6 activation of tamoxifen .
17434921	0	tamoxifen	77,86	CYP3A4	20,26	tamoxifen	CYP3A4	MESH:D013629	1576	Chemical	Gene	genotype|nmod|START_ENTITY genotype|compound|END_ENTITY	Association between CYP3A4 genotype and risk of endometrial_cancer following tamoxifen use .
15111761	0	tamoxifen	63,72	Cathepsin_D	23,34	tamoxifen	Cathepsin D	MESH:D013629	1509	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nmod|END_ENTITY	Decreased secretion of Cathepsin_D in breast_cancer in vivo by tamoxifen : mediated by the mannose-6-phosphate / IGF-II receptor ?
18794098	0	tamoxifen	123,132	Cytochrome_P450_2D6	0,19	tamoxifen	Cytochrome P450 2D6	MESH:D013629	1565	Chemical	Gene	resistance|compound|START_ENTITY prediction|nmod|resistance combining|nmod|prediction /|parataxis|combining /|nsubj|END_ENTITY	Cytochrome_P450_2D6 and homeobox_13 / interleukin-17B_receptor : combining inherited and tumor gene markers for prediction of tamoxifen resistance .
19421167	0	tamoxifen	57,66	Cytochrome_P450_2D6	0,19	tamoxifen	Cytochrome P450 2D6	MESH:D013629	1565	Chemical	Gene	therapy|compound|START_ENTITY discontinuation|nmod|therapy predicts|dobj|discontinuation predicts|nsubj|activity activity|amod|END_ENTITY	Cytochrome_P450_2D6 activity predicts discontinuation of tamoxifen therapy in breast_cancer patients .
20454926	0	tamoxifen	45,54	Cytochrome_P450_2D6	0,19	tamoxifen	Cytochrome P450 2D6	MESH:D013629	1565	Chemical	Gene	therapy|compound|START_ENTITY END_ENTITY|nmod|therapy	Cytochrome_P450_2D6 and outcomes of adjuvant tamoxifen therapy : results of a meta-analysis .
9618436	0	tamoxifen	56,65	Delta8-Delta7_sterol_isomerase	116,146	tamoxifen	Delta8-Delta7 sterol isomerase	MESH:D013629	10682	Chemical	Gene	START_ENTITY|nmod|site site|nmod|END_ENTITY	Both the immunosuppressant SR31747 and the antiestrogen tamoxifen bind to an emopamil-insensitive site of mammalian Delta8-Delta7_sterol_isomerase .
24189439	0	tamoxifen	81,90	ER	95,97	tamoxifen	ER	MESH:D013629	2099	Chemical	Gene	START_ENTITY|nmod|isoforms isoforms|compound|END_ENTITY	Autocrine production of interleukin-6 confers ovarian_cancer cells resistance to tamoxifen via ER isoforms and SRC-1 .
11689293	0	tamoxifen	39,48	ERBB2	0,5	tamoxifen	ERBB2	MESH:D013629	2064	Chemical	Gene	status|nmod|START_ENTITY status|compound|END_ENTITY	ERBB2 status and benefit from adjuvant tamoxifen in ERalpha-positive postmenopausal breast_carcinoma .
16603346	0	tamoxifen	135,144	ERK1/2	10,16	tamoxifen	ERK1/2	MESH:D013629	5595;5594	Chemical	Gene	treated|nmod|START_ENTITY women|acl|treated survival|nmod|women associated|nmod|survival associated|nsubjpass|END_ENTITY	Activated ERK1/2 and phosphorylated oestrogen receptor alpha are associated with improved breast_cancer survival in women treated with tamoxifen .
23338782	0	tamoxifen	25,34	ERK1/2	101,107	tamoxifen	ERK1/2	MESH:D013629	5595;5594	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Dose-dependent effect of tamoxifen in tamoxifen-resistant breast_cancer cells via stimulation by the ERK1/2 and AKT signaling pathways .
18974135	0	tamoxifen	18,27	ERRgamma	0,8	tamoxifen	ERRgamma	MESH:D013629	2104	Chemical	Gene	resistance|compound|START_ENTITY mediates|dobj|resistance mediates|nsubj|END_ENTITY	ERRgamma mediates tamoxifen resistance in novel models of invasive_lobular_breast_cancer .
19072471	0	tamoxifen	40,49	ErbB2	8,13	tamoxifen	ErbB2	MESH:D013629	2064	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of ErbB2 in selection for adjuvant tamoxifen or aromatase inhibitors .
19706814	0	tamoxifen	54,63	Erythropoietin_receptor	0,23	tamoxifen	Erythropoietin receptor	MESH:D013629	2057	Chemical	Gene	response|compound|START_ENTITY END_ENTITY|nmod|response	Erythropoietin_receptor expression and correlation to tamoxifen response and prognosis in breast_cancer .
11874071	0	tamoxifen	69,78	Estrogen_receptor	0,17	tamoxifen	Estrogen receptor	MESH:D013629	2099	Chemical	Gene	therapy|compound|START_ENTITY endometrial_stromal_sarcoma|nmod|therapy END_ENTITY|nmod|endometrial_stromal_sarcoma	Estrogen_receptor expression in an endometrial_stromal_sarcoma after tamoxifen therapy .
12495475	0	tamoxifen	84,93	Estrogen_receptor	0,17	tamoxifen	Estrogen receptor	MESH:D013629	2099	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Estrogen_receptor expression and estrogen_receptor-independent cytotoxic effects of tamoxifen on malignant_rhabdoid_tumor cells in vitro .
15355905	0	tamoxifen	87,96	Estrogen_receptor	0,17	tamoxifen	Estrogen receptor	MESH:D013629	2099	Chemical	Gene	resistance|compound|START_ENTITY predict|dobj|resistance helps|xcomp|predict helps|nsubj|END_ENTITY	Estrogen_receptor beta -LRB- ER_beta -RRB- level but not its ER_beta cx variant helps to predict tamoxifen resistance in breast_cancer .
1637724	0	tamoxifen	107,116	Estrogen_receptor	0,17	tamoxifen	Estrogen receptor	MESH:D013629	2099	Chemical	Gene	related|nmod|START_ENTITY related|nsubj|affinity affinity|compound|END_ENTITY	Estrogen_receptor affinity and effects on MCF-7 cell growth of triarylethylene carboxylic_acids related to tamoxifen .
19018086	0	tamoxifen	96,105	Estrogen_receptor	0,17	tamoxifen	Estrogen receptor	MESH:D013629	2099	Chemical	Gene	therapy|compound|START_ENTITY influence|nmod|therapy influence|nsubj|genotypes genotypes|compound|END_ENTITY	Estrogen_receptor genotypes influence hot flash prevalence and composite score before and after tamoxifen therapy .
19082882	0	tamoxifen	84,93	Estrogen_receptor	0,17	tamoxifen	Estrogen receptor	MESH:D013629	2099	Chemical	Gene	therapy|compound|START_ENTITY associated|nmod|therapy associated|nsubjpass|genotype genotype|compound|END_ENTITY	Estrogen_receptor genotype is associated with risk of venous_thromboembolism during tamoxifen therapy .
20215421	0	tamoxifen	55,64	Estrogen_receptor	0,17	tamoxifen	Estrogen receptor	MESH:D013629	2099	Chemical	Gene	resistance|compound|START_ENTITY mediate|dobj|resistance expression|acl|mediate regulates|dobj|expression regulates|nsubj|END_ENTITY	Estrogen_receptor regulates E2F1 expression to mediate tamoxifen resistance .
21947828	0	tamoxifen	58,67	Estrogen_receptor	0,17	tamoxifen	Estrogen receptor	MESH:D013629	2099	Chemical	Gene	mRNA|nmod|START_ENTITY mRNA|nsubj|END_ENTITY	Estrogen_receptor -LRB- ESR1 -RRB- mRNA expression and benefit from tamoxifen in the treatment and prevention of estrogen_receptor-positive_breast_cancer .
7367729	0	tamoxifen	53,62	Estrogen_receptor	0,17	tamoxifen	Estrogen receptor	MESH:D013629	2099	Chemical	Gene	therapy|compound|START_ENTITY predicts|nmod|therapy predicts|nsubj|determination determination|amod|END_ENTITY	Estrogen_receptor determination predicts response to tamoxifen therapy .
8742702	0	tamoxifen	127,136	Estrogen_receptor	0,17	tamoxifen	Estrogen receptor	MESH:D013629	2099	Chemical	Gene	exposed|nmod|START_ENTITY exposed|nsubj|END_ENTITY	Estrogen_receptor -LRB- ER -RRB- and its messenger ribonucleic acid expression in the genital tract of female mice exposed neonatally to tamoxifen and diethylstilbestrol .
18310279	0	tamoxifen	56,65	Fibroblast_growth_factor_receptor_4	0,35	tamoxifen	Fibroblast growth factor receptor 4	MESH:D013629	2264	Chemical	Gene	therapy|compound|START_ENTITY predicts|nmod|therapy predicts|nsubj|END_ENTITY	Fibroblast_growth_factor_receptor_4 predicts failure on tamoxifen therapy in patients with recurrent breast_cancer .
9758441	0	tamoxifen	46,55	GHRH	74,78	tamoxifen	GHRH	MESH:D013629	2691	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of acute and chronic administration of tamoxifen on GH response to GHRH and on IGF-I serum levels in women with breast_cancer .
14603258	0	tamoxifen	78,87	HER-2	139,144	tamoxifen	HER-2	MESH:D013629	2064	Chemical	Gene	resistance|compound|START_ENTITY overcomes|dobj|resistance overcomes|nmod|cells cells|acl:relcl|overexpress overexpress|xcomp|END_ENTITY	Herstatin inhibits heregulin-mediated breast_cancer cell growth and overcomes tamoxifen resistance in breast_cancer cells that overexpress HER-2 .
9516946	0	tamoxifen	33,42	HER-2	0,5	tamoxifen	HER-2	MESH:D013629	2064	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	HER-2 expression and response to tamoxifen in estrogen_receptor-positive_breast_cancer : a Southwest Oncology Group Study .
20649975	0	tamoxifen	54,63	HOXB13	24,30	tamoxifen	HOXB13	MESH:D013629	10481	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Predictive relevance of HOXB13 protein expression for tamoxifen benefit in breast_cancer .
23832664	0	tamoxifen	16,25	HOXB13	0,6	tamoxifen	HOXB13	MESH:D013629	10481	Chemical	Gene	resistance|compound|START_ENTITY mediates|dobj|resistance mediates|nsubj|END_ENTITY	HOXB13 mediates tamoxifen resistance and invasiveness in human breast_cancer by suppressing ERa and inducing IL-6 expression .
18396622	0	tamoxifen	75,84	Her-2	16,21	tamoxifen	Her-2	MESH:D013629	2064	Chemical	Gene	treatment|compound|START_ENTITY overexpression|nmod|treatment overexpression|nsubj|Correlation Correlation|nmod|END_ENTITY	-LSB- Correlation of Her-2 overexpression with endocrine status and response to tamoxifen treatment in patients with breast_cancer -RSB- .
1532904	0	tamoxifen	13,22	IGF-I	72,77	tamoxifen	IGF-I	MESH:D013629	3479	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|levels levels|compound|END_ENTITY	Influence of tamoxifen , aminoglutethimide and goserelin on human plasma IGF-I levels in breast_cancer patients .
15320904	0	tamoxifen	10,19	IL-18	29,34	tamoxifen	IL-18	MESH:D013629	3606	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activities activities|compound|END_ENTITY	Effect of tamoxifen on serum IL-18 , vascular_endothelial_growth_factor and nitric_oxide activities in breast_carcinoma patients .
15386482	0	tamoxifen	16,25	P-glycoprotein	76,90	tamoxifen	P-glycoprotein	MESH:D013629	5243	Chemical	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of tamoxifen , N-desmethyltamoxifen and 4-hydroxytamoxifen with P-glycoprotein and CYP3A .
12846865	0	tamoxifen	14,23	PCNA	27,31	tamoxifen	PCNA	MESH:D013629	5111	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|compound|END_ENTITY	The effect of tamoxifen on PCNA expression in fibroadenomas .
14996734	0	tamoxifen	39,48	PC_cell-derived_growth_factor	0,29	tamoxifen	PC cell-derived growth factor	MESH:D013629	2896	Chemical	Gene	resistance|compound|START_ENTITY mediates|dobj|resistance mediates|nsubj|END_ENTITY	PC_cell-derived_growth_factor mediates tamoxifen resistance and promotes tumor growth of human breast_cancer cells .
7981080	0	tamoxifen	37,46	PS2	16,19	tamoxifen	PS2	MESH:D013629	7031	Chemical	Gene	Relationship|acl|START_ENTITY Relationship|nmod|END_ENTITY	Relationship of PS2 with response to tamoxifen therapy in patients with recurrent breast_cancer .
12408377	0	tamoxifen	116,125	Progesterone_receptor	0,21	tamoxifen	Progesterone receptor	MESH:D013629	5241	Chemical	Gene	therapy|compound|START_ENTITY quantification|nmod|therapy quantification|nsubj|END_ENTITY	Progesterone_receptor quantification as a strong prognostic determinant in postmenopausal_breast_cancer women under tamoxifen therapy .
17641532	0	tamoxifen	31,40	Protein_kinase_C	0,16	tamoxifen	Protein kinase C	MESH:D013629	24681(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Protein_kinase_C inhibition by tamoxifen antagonizes manic-like behavior in rats : implications for the development of novel therapeutics for bipolar_disorder .
18316672	0	tamoxifen	99,108	Protein_kinase_C	0,16	tamoxifen	Protein kinase C	MESH:D013629	112476	Chemical	Gene	trial|nmod|START_ENTITY inhibition|dep|trial inhibition|amod|END_ENTITY	Protein_kinase_C inhibition in the treatment of mania : a double-blind , placebo-controlled trial of tamoxifen .
24178749	0	tamoxifen	14,23	Sox2	0,4	tamoxifen	Sox2	MESH:D013629	6657	Chemical	Gene	resistance|compound|START_ENTITY promotes|dobj|resistance promotes|nsubj|END_ENTITY	Sox2 promotes tamoxifen resistance in breast_cancer cells .
19547888	0	tamoxifen	12,21	TGF-beta	43,51	tamoxifen	TGF-beta	MESH:D013629	7040	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|proteins proteins|amod|END_ENTITY	-LSB- Effects of tamoxifen on the expression of TGF-beta and p27 proteins in polyps and adjacent endometrium in postmenopausal women -RSB- .
15640959	0	tamoxifen	210,219	TGF-beta1	150,159	tamoxifen	TGF-beta1	MESH:D013629	7040	Chemical	Gene	transforming|nmod|START_ENTITY transforming|dobj|factor factor|appos|END_ENTITY	Early nuclear alterations and immunohistochemical expression of Ki-67 , Erb-B2 , vascular_endothelial_growth_factor -LRB- VEGF -RRB- , transforming growth factor -LRB- TGF-beta1 -RRB- and integrine-linked kinase -LRB- ILK -RRB- two days after tamoxifen in breast_carcinoma .
12017331	0	tamoxifen	17,26	TGF-beta2	81,90	tamoxifen	TGF-beta2	MESH:D013629	7042	Chemical	Gene	influence|nmod|START_ENTITY influence|nmod|secretion secretion|nmod|END_ENTITY	The influence of tamoxifen on the secretion of transforming_growth_factor-beta2 -LRB- TGF-beta2 -RRB- in glioblastomas : in vitro and in vivo findings .
11056313	0	tamoxifen	71,80	TGFbeta	59,66	tamoxifen	TGFbeta	MESH:D013629	7040	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|appos|END_ENTITY	Modulation of endometrial transforming_growth_factor_beta -LRB- TGFbeta -RRB- by tamoxifen .
24924200	0	tamoxifen	77,86	TIMP3	111,116	tamoxifen	TIMP3	MESH:D013629	7078	Chemical	Gene	START_ENTITY|nmod|upregulation upregulation|nmod|END_ENTITY	Downregulation of miR-221 / 222 enhances sensitivity of breast_cancer cells to tamoxifen through upregulation of TIMP3 .
12016389	0	tamoxifen	40,49	Thymidine_phosphorylase	0,23	tamoxifen	Thymidine phosphorylase	MESH:D013629	1890	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Thymidine_phosphorylase is regulated by tamoxifen in T47D_breast_cancer cell line .
16884532	0	tamoxifen	20,29	UGT1A4	78,84	tamoxifen	UGT1A4	MESH:D013629	54657	Chemical	Gene	glucuronidation|compound|START_ENTITY glucuronidation|nmod|END_ENTITY	Characterization of tamoxifen and 4-hydroxytamoxifen glucuronidation by human UGT1A4 variants .
11416020	0	tamoxifen	38,47	UO-44	13,18	tamoxifen	UO-44	MESH:D013629	117179(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Induction of UO-44 gene expression by tamoxifen in the rat uterus and ovary .
24377619	0	tamoxifen	23,32	VEGF	50,54	tamoxifen	VEGF	MESH:D013629	7422	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|regulation regulation|amod|END_ENTITY	Synergistic effects of tamoxifen and tranilast on VEGF and MMP-9 regulation in cultured human breast_cancer cells .
12865915	0	tamoxifen	97,106	Vascular_endothelial_growth_factor	0,34	tamoxifen	Vascular endothelial growth factor	MESH:D013629	7422	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|END_ENTITY	Vascular_endothelial_growth_factor in node-positive_breast_cancer patients treated with adjuvant tamoxifen .
19440904	0	tamoxifen	117,126	Vascular_endothelial_growth_factor	0,34	tamoxifen	Vascular endothelial growth factor	MESH:D013629	83785(Tax:10116)	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|expression expression|amod|END_ENTITY	Vascular_endothelial_growth_factor expression in the urethral epithelium of castrated adult female rats treated with tamoxifen .
6603815	0	tamoxifen	14,23	alpha_1-antitrypsin	40,59	tamoxifen	alpha 1-antitrypsin	MESH:D013629	5265	Chemical	Gene	START_ENTITY|nmod|deficiency deficiency|amod|END_ENTITY	The effect of tamoxifen in intermediate alpha_1-antitrypsin deficiency associated with the phenotype PiSZ .
7577712	0	tamoxifen	23,32	calbindin-D_9k	69,83	tamoxifen	calbindin-D 9k	MESH:D013629	24249(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Contrasting effects of tamoxifen and ICI_182_780 on estrogen-induced calbindin-D_9k gene expression in the uterus and in primary culture of myometrial cells .
17115111	0	tamoxifen	73,82	cytochrome_P450_2D6	14,33	tamoxifen	cytochrome P450 2D6	MESH:D013629	1565	Chemical	Gene	receiving|dobj|START_ENTITY impact|acl|receiving impact|nmod|metabolism metabolism|amod|END_ENTITY	The impact of cytochrome_P450_2D6 metabolism in women receiving adjuvant tamoxifen .
20141708	0	tamoxifen	21,30	cytochrome_P450_2D6	55,74	tamoxifen	cytochrome P450 2D6	MESH:D013629	1565	Chemical	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions between tamoxifen and antidepressants via cytochrome_P450_2D6 .
20309015	0	tamoxifen	12,21	cytochrome_P450_2D6	31,50	tamoxifen	cytochrome P450 2D6	MESH:D013629	1565	Chemical	Gene	START_ENTITY|acl|based based|nmod|END_ENTITY	Efficacy of tamoxifen based on cytochrome_P450_2D6 , CYP2C19 and SULT1A1 genotype in the Italian Tamoxifen Prevention Trial .
23289191	0	tamoxifen	125,134	cytochrome_P450_2D6	40,59	tamoxifen	cytochrome P450 2D6	MESH:D013629	1565	Chemical	Gene	treated|nmod|START_ENTITY breast_cancer|acl|treated associated|nmod|breast_cancer associated|nmod|genotype genotype|amod|END_ENTITY	Side effects associated with ultrarapid cytochrome_P450_2D6 genotype among women with early stage breast_cancer treated with tamoxifen .
17576039	0	tamoxifen	24,33	endothelin-1	8,20	tamoxifen	endothelin-1	MESH:D013629	1906	Chemical	Gene	resistance|compound|START_ENTITY END_ENTITY|nmod|resistance	Role of endothelin-1 in tamoxifen resistance : Mechanism for a new possible treatment strategy in breast_cancer .
10601607	0	tamoxifen	72,81	estrogen_receptor	14,31	tamoxifen	estrogen receptor	MESH:D013629	2099	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of estrogen_receptor and epidermal_growth_factor_receptor by tamoxifen under high and low estrogen environments in MCF-7 cells grown in athymic mice .
11306468	0	tamoxifen	14,23	estrogen_receptor	122,139	tamoxifen	estrogen receptor	MESH:D013629	2099	Chemical	Gene	resistance|compound|START_ENTITY antiestrogens|nsubj|resistance antiestrogens|ccomp|induce induce|nmod|END_ENTITY	Circumventing tamoxifen resistance in breast_cancers using antiestrogens that induce unique conformational changes in the estrogen_receptor .
12618500	0	tamoxifen	72,81	estrogen_receptor	12,29	tamoxifen	estrogen receptor	MESH:D013629	2099	Chemical	Gene	resistance|compound|START_ENTITY neu|nmod|resistance Role|dep|neu Role|nmod|AIB1 AIB1|compound|END_ENTITY	Role of the estrogen_receptor coactivator AIB1 -LRB- SRC-3 -RRB- and HER-2 / neu in tamoxifen resistance in breast_cancer .
14559845	0	tamoxifen	83,92	estrogen_receptor	28,45	tamoxifen	estrogen receptor	MESH:D013629	2099	Chemical	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|arzoxifene arzoxifene|compound|END_ENTITY	Comparison of the selective estrogen_receptor modulator arzoxifene -LRB- LY353381 -RRB- with tamoxifen on tumor growth and biomarker expression in an MCF-7 human breast_cancer xenograft model .
16455819	0	tamoxifen	102,111	estrogen_receptor	32,49	tamoxifen	estrogen receptor	MESH:D013629	2099	Chemical	Gene	actions|nmod|START_ENTITY regulates|dobj|actions regulates|nsubj|domain domain|nmod|END_ENTITY	Activation function-1 domain of estrogen_receptor regulates the agonistic and antagonistic actions of tamoxifen .
16457696	0	tamoxifen	49,58	estrogen_receptor	99,116	tamoxifen	estrogen receptor	MESH:D013629	2099	Chemical	Gene	inhibition|compound|START_ENTITY enhances|dobj|inhibition enhances|nmod|pathways pathways|amod|END_ENTITY	Farnesyl-transferase inhibitor R115 ,777 enhances tamoxifen inhibition of MCF-7 cell growth through estrogen_receptor dependent and independent pathways .
16621526	0	tamoxifen	62,71	estrogen_receptor	4,21	tamoxifen	estrogen receptor	MESH:D013629	2099	Chemical	Gene	breast_cancer|nmod|START_ENTITY Are|nmod|breast_cancer Are|nsubj|content content|compound|END_ENTITY	Are estrogen_receptor content in breast_cancer and effects of tamoxifen on sex_hormone-binding_globulin markers for individual estrogen sensitivity ?
17157789	0	tamoxifen	101,110	estrogen_receptor	14,31	tamoxifen	estrogen receptor	MESH:D013629	2099	Chemical	Gene	sensitivity|compound|START_ENTITY restores|dobj|sensitivity restores|nsubj|Disruption Disruption|nmod|domain domain|compound|END_ENTITY	Disruption of estrogen_receptor DNA-binding domain and related intramolecular communication restores tamoxifen sensitivity in resistant breast_cancer .
17178225	0	tamoxifen	134,143	estrogen_receptor	57,74	tamoxifen	estrogen receptor	MESH:D013629	2099	Chemical	Gene	treated|nmod|START_ENTITY women|acl|treated breast|nmod|women epithelial|nmod|breast epithelial|dobj|alteration alteration|nmod|END_ENTITY	Nonproliferative epithelial alteration and expression of estrogen_receptor and Ki67 in the contralateral breast of women treated with tamoxifen for breast_cancer .
17599049	0	tamoxifen	160,169	estrogen_receptor	83,100	tamoxifen	estrogen receptor	MESH:D013629	2099	Chemical	Gene	repression|nmod|START_ENTITY repression|nmod|recruitment recruitment|nmod|END_ENTITY	Estrogen-induced and TAFII30-mediated gene repression by direct recruitment of the estrogen_receptor and co-repressors to the core promoter and its reversal by tamoxifen .
17704057	0	tamoxifen	35,44	estrogen_receptor	83,100	tamoxifen	estrogen receptor	MESH:D013629	2099	Chemical	Gene	activity|nmod|START_ENTITY reveals|nsubj|activity reveals|dobj|association association|nmod|END_ENTITY	Anti-hepatitis_C virus activity of tamoxifen reveals the functional association of estrogen_receptor with viral RNA polymerase NS5B .
18755852	0	tamoxifen	31,40	estrogen_receptor	84,101	tamoxifen	estrogen receptor	MESH:D013629	2099	Chemical	Gene	binding|nmod|START_ENTITY site|amod|binding Implications|nmod|site Implications|nmod|END_ENTITY	Implications of the binding of tamoxifen to the coactivator recognition site of the estrogen_receptor .
19847644	0	tamoxifen	155,164	estrogen_receptor	44,61	tamoxifen	estrogen receptor	MESH:D013629	2099	Chemical	Gene	resistance|compound|START_ENTITY factor|nmod|resistance possibility|nmod|factor cells|dep|possibility enhance|nmod|cells END_ENTITY|xcomp|enhance	Menin , a product of the MENI gene , binds to estrogen_receptor to enhance its activity in breast_cancer cells : possibility of a novel predictive factor for tamoxifen resistance .
20944147	0	tamoxifen	145,154	estrogen_receptor	115,132	tamoxifen	estrogen receptor	MESH:D013629	2099	Chemical	Gene	resistance|compound|START_ENTITY END_ENTITY|nmod|resistance	The Wilms ' _ tumor suppressor WT1 regulates expression of members of the epidermal_growth_factor_receptor -LRB- EGFR -RRB- and estrogen_receptor in acquired tamoxifen resistance .
20957430	0	tamoxifen	138,147	estrogen_receptor	69,86	tamoxifen	estrogen receptor	MESH:D013629	2099	Chemical	Gene	Immunohistochemistry|nmod|START_ENTITY Immunohistochemistry|nmod|END_ENTITY	Immunohistochemistry compared to cytosol assays for determination of estrogen_receptor and prediction of the long-term effect of adjuvant tamoxifen .
22295213	0	tamoxifen	66,75	estrogen_receptor	11,28	tamoxifen	estrogen receptor	MESH:D013629	2099	Chemical	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nsubj|role role|nmod|END_ENTITY	A role for estrogen_receptor phosphorylation in the resistance to tamoxifen .
22606272	0	tamoxifen	80,89	estrogen_receptor	36,53	tamoxifen	estrogen receptor	MESH:D013629	2099	Chemical	Gene	predicts|nmod|START_ENTITY predicts|nsubj|Quantitative Quantitative|nmod|measurement measurement|nmod|mRNA mRNA|compound|END_ENTITY	Quantitative in situ measurement of estrogen_receptor mRNA predicts response to tamoxifen .
23404426	0	tamoxifen	97,106	estrogen_receptor	31,48	tamoxifen	estrogen receptor	MESH:D013629	2099	Chemical	Gene	cells|nmod|START_ENTITY Inhibition|dep|cells Inhibition|nmod|proliferation proliferation|nmod|END_ENTITY	Inhibition of proliferation of estrogen_receptor - positive MCF -7 human breast_cancer cells by tamoxifen through c __ - Jun transcription factors .
2350488	0	tamoxifen	48,57	estrogen_receptor	90,107	tamoxifen	estrogen receptor	MESH:D013629	2099	Chemical	Gene	analogue|compound|START_ENTITY analogue|acl:relcl|bind bind|dobj|END_ENTITY	Comparison of the effects of tamoxifen and of a tamoxifen analogue that does not bind the estrogen_receptor on serum lipid profiles in the cockerel .
23688426	0	tamoxifen	6,15	estrogen_receptor	82,99	tamoxifen	estrogen receptor	MESH:D013629	2099	Chemical	Gene	Ridaifen-B|amod|START_ENTITY induces|nsubj|Ridaifen-B induces|nmod|involvement involvement|compound|END_ENTITY	Novel tamoxifen derivative Ridaifen-B induces Bcl-2 independent autophagy without estrogen_receptor involvement .
24332630	0	tamoxifen	24,33	estrogen_receptor	61,78	tamoxifen	estrogen receptor	MESH:D013629	2099	Chemical	Gene	derivatives|compound|START_ENTITY Design|nmod|derivatives Design|nmod|down-regulator down-regulator|compound|END_ENTITY	Design and synthesis of tamoxifen derivatives as a selective estrogen_receptor down-regulator .
24930824	0	tamoxifen	92,101	estrogen_receptor	33,50	tamoxifen	estrogen receptor	MESH:D013629	2099	Chemical	Gene	raloxifene|amod|START_ENTITY practice|appos|raloxifene modulators|nmod|practice modulators|compound|END_ENTITY	Acquired resistance to selective estrogen_receptor modulators -LRB- SERMs -RRB- in clinical practice -LRB- tamoxifen _ raloxifene -RRB- by selection pressure in breast_cancer cell populations .
26657294	0	tamoxifen	59,68	estrogen_receptor	72,89	tamoxifen	estrogen receptor	MESH:D013629	2099	Chemical	Gene	START_ENTITY|nmod|breast_cancer breast_cancer|amod|END_ENTITY	Annexin-A1 and caldesmon are associated with resistance to tamoxifen in estrogen_receptor positive recurrent breast_cancer .
3779632	0	tamoxifen	74,83	estrogen_receptor	29,46	tamoxifen	estrogen receptor	MESH:D013629	2099	Chemical	Gene	Effect|acl|START_ENTITY Effect|nmod|drugs drugs|nmod|expression expression|compound|END_ENTITY	Effect of cytotoxic drugs on estrogen_receptor expression and response to tamoxifen in MCF-7 cells .
638966	0	tamoxifen	25,34	estrogen_receptor	110,127	tamoxifen	estrogen receptor	MESH:D013629	2099	Chemical	Gene	START_ENTITY|nmod|treatment treatment|nmod|breast_cancer breast_cancer|nmod|correlation correlation|nmod|values values|compound|END_ENTITY	The use of antiestrogens tamoxifen and nafoxidine in the treatment of human breast_cancer in correlation with estrogen_receptor values .
6734930	0	tamoxifen	32,41	estrogen_receptor	83,100	tamoxifen	estrogen receptor	MESH:D013629	2099	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|mediation mediation|nmod|END_ENTITY	The antiproliferative effect of tamoxifen in breast_cancer cells : mediation by the estrogen_receptor .
7476979	0	tamoxifen	89,98	estrogen_receptor	22,39	tamoxifen	estrogen receptor	MESH:D013629	2099	Chemical	Gene	analog|compound|START_ENTITY estrogenicity|nmod|analog results|nmod|estrogenicity results|nsubj|mutation mutation|compound|END_ENTITY	A naturally occurring estrogen_receptor mutation results in increased estrogenicity of a tamoxifen analog .
7579506	0	tamoxifen	9,18	estrogen_receptor	58,75	tamoxifen	estrogen receptor	MESH:D013629	2099	Chemical	Gene	START_ENTITY|nmod|women women|nmod|breast_cancer breast_cancer|amod|positive positive|amod|END_ENTITY	Adjuvant tamoxifen for pre - and postmenopausal women with estrogen_receptor positive , node positive breast_cancer : a randomized study .
7664983	0	tamoxifen	73,82	estrogen_receptor	27,44	tamoxifen	estrogen receptor	MESH:D013629	2099	Chemical	Gene	resistant|amod|START_ENTITY line|amod|resistant variants|nmod|line variants|nsubj|expression expression|nmod|splice splice|compound|END_ENTITY	Differential expression of estrogen_receptor mRNA splice variants in the tamoxifen resistant human breast_cancer cell line , MCF-7 / TAMR-1 compared to the parental MCF-7 cell line .
7812959	0	tamoxifen	82,91	estrogen_receptor	24,41	tamoxifen	estrogen receptor	MESH:D013629	2099	Chemical	Gene	resistance|compound|START_ENTITY expression|nmod|resistance 5|parataxis|expression 5|dep|messenger messenger|compound|END_ENTITY	Exon 5 deletion variant estrogen_receptor messenger RNA expression in relation to tamoxifen resistance and progesterone_receptor / pS2 status in human breast_cancer .
7981453	0	tamoxifen	29,38	estrogen_receptor	4,21	tamoxifen	estrogen receptor	MESH:D013629	2099	Chemical	Gene	variant|amod|START_ENTITY END_ENTITY|nmod|variant	The estrogen_receptor from a tamoxifen stimulated MCF-7 tumor variant contains a point mutation in the ligand binding domain .
8129752	0	tamoxifen	48,57	estrogen_receptor	97,114	tamoxifen	estrogen receptor	MESH:D013629	2099	Chemical	Gene	side-chain|nmod|START_ENTITY bearing|dobj|side-chain derivatives|acl|bearing antagonize|nsubj|derivatives antagonize|dobj|association association|nmod|END_ENTITY	Estradiol derivatives bearing the side-chain of tamoxifen antagonize the association between the estrogen_receptor and calmodulin .
8382104	0	tamoxifen	38,47	estrogen_receptor	17,34	tamoxifen	estrogen receptor	MESH:D013629	2099	Chemical	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|END_ENTITY	Up-regulation of estrogen_receptor by tamoxifen in human breast_cancer .
9806352	0	tamoxifen	14,23	estrogen_receptor	35,52	tamoxifen	estrogen receptor	MESH:D013629	2099	Chemical	Gene	Comparison|nmod|START_ENTITY ligands|nsubj|Comparison ligands|nmod|interaction interaction|compound|END_ENTITY	Comparison of tamoxifen ligands on estrogen_receptor interaction with estrogen response elements .
9816287	0	tamoxifen	114,123	estrogen_receptor	50,67	tamoxifen	estrogen receptor	MESH:D013629	2099	Chemical	Gene	efficacy|nmod|START_ENTITY predicting|dobj|efficacy END_ENTITY|advcl|predicting	Determination of angiogenesis adds information to estrogen_receptor status in predicting the efficacy of adjuvant tamoxifen in node-positive_breast_cancer patients .
9875847	0	tamoxifen	108,117	estrogen_receptor	24,41	tamoxifen	estrogen receptor	MESH:D013629	2099	Chemical	Gene	interaction|nmod|START_ENTITY recognition|nmod|interaction basis|dep|recognition basis|nmod|END_ENTITY	The structural basis of estrogen_receptor / coactivator recognition and the antagonism of this interaction by tamoxifen .
9928564	0	tamoxifen	72,81	estrogen_receptor	25,42	tamoxifen	estrogen receptor	MESH:D013629	2099	Chemical	Gene	resistance|amod|START_ENTITY understanding|nmod|resistance aids|nmod|understanding aids|nsubj|biology biology|nmod|END_ENTITY	Molecular biology of the estrogen_receptor aids in the understanding of tamoxifen resistance and breast cancer prevention with raloxifene .
21329476	0	tamoxifen	11,20	estrogen_receptor-a	24,43	tamoxifen	estrogen receptor-a	MESH:D013629	13982(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|level level|amod|END_ENTITY	Effects of tamoxifen on estrogen_receptor-a level in immune cells and humoral specific response after immunization of C3H/He male mice with syngeneic testicular germ cells -LRB- TGC -RRB- .
21509526	0	tamoxifen	96,105	estrogen_receptor_a	109,128	tamoxifen	estrogen receptor a	MESH:D013629	2099	Chemical	Gene	START_ENTITY|nmod|breast_cancer breast_cancer|amod|END_ENTITY	KX-01 , a novel Src kinase inhibitor directed toward the peptide substrate site , synergizes with tamoxifen in estrogen_receptor_a positive breast_cancer .
19472088	0	tamoxifen	80,89	growth_hormone	16,30	tamoxifen	growth hormone	MESH:D013629	2688	Chemical	Gene	leads|nmod|START_ENTITY leads|nsubj|expression expression|amod|END_ENTITY	Autocrine human growth_hormone expression leads to resistance of MCF-7 cells to tamoxifen .
6684048	0	tamoxifen	14,23	growth_hormone	34,48	tamoxifen	growth hormone	MESH:D013629	2688	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of tamoxifen on plasma growth_hormone and prolactin in postmenopausal women with advanced_breast_cancer .
1952114	0	tamoxifen	144,153	hCG	181,184	tamoxifen	hCG	MESH:D013629	3342	Chemical	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	Effect of an antiestrogen on the testicular response to acute and chronic administration of hCG in normal and hypogonadotropic hypogonadic men : tamoxifen and testicular response to hCG .
1952114	0	tamoxifen	144,153	hCG	92,95	tamoxifen	hCG	MESH:D013629	3342	Chemical	Gene	response|compound|START_ENTITY Effect|dep|response Effect|nmod|END_ENTITY	Effect of an antiestrogen on the testicular response to acute and chronic administration of hCG in normal and hypogonadotropic hypogonadic men : tamoxifen and testicular response to hCG .
9464719	0	tamoxifen	15,24	insulin-like_growth_factor-1	40,68	tamoxifen	insulin-like growth factor-1	MESH:D013629	3479	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|amod|END_ENTITY	The effects of tamoxifen on endometrial insulin-like_growth_factor-1 expression .
24467828	0	tamoxifen	147,156	insulin-like_growth_factor_1_receptor	96,133	tamoxifen	insulin-like growth factor 1 receptor	MESH:D013629	3480	Chemical	Gene	resistance|compound|START_ENTITY resistance|amod|END_ENTITY	PIK3CA mutations , phosphatase and tensin homolog , human epidermal_growth_factor_receptor_2 , and insulin-like_growth_factor_1_receptor and adjuvant tamoxifen resistance in postmenopausal_breast_cancer patients .
15278900	0	tamoxifen	19,28	insulin-like_growth_factor_2	50,78	tamoxifen	insulin-like growth factor 2	MESH:D013629	24483(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|acl|END_ENTITY	Effect of paternal tamoxifen on the expression of insulin-like_growth_factor_2 and insulin-like_growth_factor_type_1_receptor in the post-implantation rat embryos .
2924327	0	tamoxifen	10,19	insulin-like_growth_factor_I	30,58	tamoxifen	insulin-like growth factor I	MESH:D013629	3479	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of tamoxifen on plasma insulin-like_growth_factor_I in patients with breast_cancer .
7518340	0	tamoxifen	135,144	insulin-like_growth_factor_I	7,35	tamoxifen	insulin-like growth factor I	MESH:D013629	3479	Chemical	Gene	receiving|dobj|START_ENTITY breast_cancer|acl|receiving END_ENTITY|nmod|breast_cancer	Plasma insulin-like_growth_factor_I and its binding proteins_1_and_3 in postmenopausal patients with breast_cancer receiving long term tamoxifen .
8467486	0	tamoxifen	70,79	insulin-like_growth_factor_I	22,50	tamoxifen	insulin-like growth factor I	MESH:D013629	3479	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	In vivo inhibition of insulin-like_growth_factor_I gene expression by tamoxifen .
8752178	0	tamoxifen	102,111	insulin-like_growth_factor_I	15,43	tamoxifen	insulin-like growth factor I	MESH:D013629	3479	Chemical	Gene	predicts|nmod|START_ENTITY predicts|nsubj|Presence Presence|nmod|loop loop|amod|END_ENTITY	Presence of an insulin-like_growth_factor_I autocrine loop predicts uterine fibroid responsiveness to tamoxifen .
2231756	0	tamoxifen	10,19	insulinlike_growth_factor_I	29,56	tamoxifen	insulinlike growth factor I	MESH:D013629	3479	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|compound|END_ENTITY	Effect of tamoxifen on serum insulinlike_growth_factor_I levels in stage_I_breast_cancer patients .
1525393	0	tamoxifen	92,101	interferon-alpha_2b	12,31	tamoxifen	interferon-alpha 2b	MESH:D013629	3440	Chemical	Gene	affects|nmod|START_ENTITY affects|nsubj|END_ENTITY	Recombinant interferon-alpha_2b affects proliferation , steroid receptors and sensitivity to tamoxifen of cultured breast_cancer cells -LRB- CG-5 -RRB- .
9051698	0	tamoxifen	149,158	interferon_alpha_2b	184,203	tamoxifen	interferon alpha 2b	MESH:D013629	3440	Chemical	Gene	therapy|amod|START_ENTITY therapy|amod|END_ENTITY	Altered uterine sensitivity to oxytocin and prostaglandin_F2_alpha in dimethylbenz -LRB- a -RRB- anthracene -LRB- DMBA -RRB- - induced rat mammary_carcinoma : the effects of tamoxifen and/or recombinant human interferon_alpha_2b therapy .
11689595	0	tamoxifen	11,20	leptin	34,40	tamoxifen	leptin	MESH:D013629	3952	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|level level|compound|END_ENTITY	Effects of tamoxifen on the serum leptin level in patients with breast_cancer .
14760064	0	tamoxifen	123,132	maspin	37,43	tamoxifen	maspin	MESH:D013629	5268	Chemical	Gene	properties|nmod|START_ENTITY mechanism|nmod|properties END_ENTITY|dep|mechanism	Regulating the tumor suppressor gene maspin in breast_cancer cells : a potential mechanism for the anticancer properties of tamoxifen .
16866022	0	tamoxifen	112,121	monocyte_chemotactic_protein-1	14,44	tamoxifen	monocyte chemotactic protein-1	MESH:D013629	6347	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of monocyte_chemotactic_protein-1 in human endometrial_cancer cells and the effect of treatment with tamoxifen or buserelin .
17604944	0	tamoxifen	50,59	p21-activated_kinase_1	8,30	tamoxifen	p21-activated kinase 1	MESH:D013629	5058	Chemical	Gene	sensitivity|compound|START_ENTITY sensitivity|amod|END_ENTITY	Sliding p21-activated_kinase_1 to nucleus impacts tamoxifen sensitivity .
21119367	0	tamoxifen	103,112	p53	14,17	tamoxifen	p53	MESH:D013629	7157	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|Expression Expression|nmod|END_ENTITY	Expression of p53 , Ki-67 , and CD31 proteins in endometrial_polyps of postmenopausal women treated with tamoxifen .
7812959	0	tamoxifen	82,91	pS2	129,132	tamoxifen	pS2	MESH:D013629	338412	Chemical	Gene	resistance|compound|START_ENTITY expression|nmod|resistance expression|dep|status status|amod|END_ENTITY	Exon 5 deletion variant estrogen_receptor messenger RNA expression in relation to tamoxifen resistance and progesterone_receptor / pS2 status in human breast_cancer .
7953346	0	tamoxifen	122,131	pS2	31,34	tamoxifen	pS2	MESH:D013629	338412	Chemical	Gene	response|acl|START_ENTITY guide|nmod|response guide|nsubj|staining staining|nmod|protein protein|amod|END_ENTITY	Immunocytochemical staining of pS2 protein in fine-needle aspirate from breast_cancer is an accurate guide to response to tamoxifen in patients aged over 70 years .
8855985	0	tamoxifen	70,79	pS2	0,3	tamoxifen	pS2	MESH:D013629	338412	Chemical	Gene	prediction|nmod|START_ENTITY protein|dep|prediction protein|amod|END_ENTITY	pS2 protein : a marker improving prediction of response to neoadjuvant tamoxifen in post-menopausal breast_cancer patients .
9260605	0	tamoxifen	10,19	pS2	23,26	tamoxifen	pS2	MESH:D013629	338412	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of tamoxifen on pS2 expression in human breast_cancers .
10754487	0	tamoxifen	162,171	progesterone_receptor	27,48	tamoxifen	progesterone receptor	MESH:D013629	5241	Chemical	Gene	predicting|advcl|START_ENTITY immuno-histochemistry|acl|predicting compared|nmod|immuno-histochemistry assay|acl|compared END_ENTITY|nmod|assay	Estrogen receptor -LRB- ER -RRB- and progesterone_receptor -LRB- PgR -RRB- , by ligand-binding assay compared with ER , PgR and pS2 , by immuno-histochemistry in predicting response to tamoxifen in metastatic breast_cancer : a Southwest Oncology Group Study .
1540937	0	tamoxifen	85,94	progesterone_receptor	175,196	tamoxifen	progesterone receptor	MESH:D013629	5241	Chemical	Gene	treatment|nmod|START_ENTITY endometrial_carcinoma|nmod|treatment resistance|nmod|endometrial_carcinoma result|nsubj|resistance result|nmod|downregulation downregulation|nmod|END_ENTITY	Apparent resistance in human endometrial_carcinoma during combination treatment with tamoxifen and progestin may result from desensitization following downregulation of tumor progesterone_receptor .
1634918	0	tamoxifen	138,147	progesterone_receptor	27,48	tamoxifen	progesterone receptor	MESH:D013629	5241	Chemical	Gene	treated|nmod|START_ENTITY breast_cancer|acl|treated patients|nmod|breast_cancer levels|nmod|patients levels|compound|END_ENTITY	Prognostic significance of progesterone_receptor levels in estrogen_receptor-positive patients with metastatic breast_cancer treated with tamoxifen : results of a prospective Southwest Oncology Group study .
16899609	0	tamoxifen	75,84	progesterone_receptor	5,26	tamoxifen	progesterone receptor	MESH:D013629	5241	Chemical	Gene	effect|nmod|START_ENTITY correlates|nmod|effect correlates|nsubj|expression expression|compound|END_ENTITY	High progesterone_receptor expression correlates to the effect of adjuvant tamoxifen in premenopausal_breast_cancer patients .
21327800	0	tamoxifen	131,140	progesterone_receptor	25,46	tamoxifen	progesterone receptor	MESH:D013629	5241	Chemical	Gene	breast_cancer|nmod|START_ENTITY significance|nmod|breast_cancer significance|nmod|status status|compound|END_ENTITY	Clinical significance of progesterone_receptor and HER2 status in estrogen_receptor-positive , operable breast_cancer with adjuvant tamoxifen .
26597778	0	tamoxifen	77,86	progesterone_receptor	44,65	tamoxifen	progesterone receptor	MESH:D013629	25154(Tax:10116)	Chemical	Gene	redistribution|nmod|START_ENTITY redistribution|nmod|A A|compound|END_ENTITY	Induction and subcellular redistribution of progesterone_receptor A and B by tamoxifen in the hypothalamic ventromedial neurons of young adult female Wistar_rats .
2964264	0	tamoxifen	40,49	progesterone_receptor	13,34	tamoxifen	progesterone receptor	MESH:D013629	5241	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of progesterone_receptor with tamoxifen in human breast_cancer with special reference to its behavior over time .
3791215	0	tamoxifen	91,100	progesterone_receptor	124,145	tamoxifen	progesterone receptor	MESH:D013629	5241	Chemical	Gene	START_ENTITY|nmod|concentrations concentrations|nmod|END_ENTITY	Endocrine therapy for advanced carcinoma_of_the_breast : relationship between the effect of tamoxifen upon concentrations of progesterone_receptor and subsequent response to treatment .
7371003	0	tamoxifen	37,46	progesterone_receptor	12,33	tamoxifen	progesterone receptor	MESH:D013629	5241	Chemical	Gene	Increase|nmod|START_ENTITY Increase|nmod|END_ENTITY	Increase of progesterone_receptor by tamoxifen as a hormonal challenge test in breast_cancer .
7579503	0	tamoxifen	63,72	progesterone_receptor	89,110	tamoxifen	progesterone receptor	MESH:D013629	5241	Chemical	Gene	START_ENTITY|advmod|especially especially|nmod|END_ENTITY	Recurrence-free survival in breast_cancer improved by adjuvant tamoxifen -- especially for progesterone_receptor positive tumors with a high proliferation .
16101186	0	tamoxifen	20,29	prolactin	102,111	tamoxifen	prolactin	MESH:D013629	5617	Chemical	Gene	study|nmod|START_ENTITY study|dep|relation relation|nmod|secretion secretion|compound|END_ENTITY	A phase II study of tamoxifen in hormone-resistant metastatic_prostate_cancer : possible relation with prolactin secretion .
3086201	0	tamoxifen	19,28	prolactin	81,90	tamoxifen	prolactin	MESH:D013629	5617	Chemical	Gene	interfere|nsubj|START_ENTITY interfere|nmod|control control|nmod|release release|compound|END_ENTITY	The anti-oestrogen tamoxifen does not interfere with the dopaminergic control of prolactin and TSH release in normogonadotrophic oligozoospermic man .
3822918	0	tamoxifen	47,56	prolactin	8,17	tamoxifen	prolactin	MESH:D013629	24683(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY modulating|dobj|effects END_ENTITY|acl|modulating	Role of prolactin in modulating the effects of tamoxifen on growth of the Dunning R3327 rat prostate adenocarcinoma .
6193975	0	tamoxifen	11,20	prolactin	100,109	tamoxifen	prolactin	MESH:D013629	5617	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|hormone hormone|appos|END_ENTITY	Effects of tamoxifen on the levels of luteinizing hormone -LRB- LH -RRB- , follicle stimulating hormone -LRB- FSH -RRB- , prolactin -LRB- PRL -RRB- , 17_beta-oestradiol -LRB- E2 -RRB- , total_and_free_testosterone _ -LRB- T -RRB- _ and_total_and_free_dihydrotestosterone -LRB- DHT -RRB- in blood of patients with benign_prostatic_hyperplasia .
6697292	0	tamoxifen	23,32	prolactin	54,63	tamoxifen	prolactin	MESH:D013629	24683(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|weight weight|compound|END_ENTITY	Comparative effects of tamoxifen and bromocriptine on prolactin and pituitary weight in estradiol-treated male rats .
8181575	0	tamoxifen	29,38	prolactin	11,20	tamoxifen	prolactin	MESH:D013629	5617	Chemical	Gene	resistance|compound|START_ENTITY predict|dobj|resistance predict|nsubj|END_ENTITY	Can plasma prolactin predict tamoxifen resistance in patients with advanced breast_cancer ?
8740191	0	tamoxifen	11,20	prolactin	30,39	tamoxifen	prolactin	MESH:D013629	24683(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|compound|END_ENTITY	Effects of tamoxifen on serum prolactin levels , pituitary immunoreactive prolactin cells and uterine growth in estradiol-treated ovariectomized rats .
15379424	0	tamoxifen	14,23	sex_hormone_binding_globulin	27,55	tamoxifen	sex hormone binding globulin	MESH:D013629	6462	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of tamoxifen on sex_hormone_binding_globulin in adolescents with pubertal gynecomastia .
3607780	0	tamoxifen	32,41	sex_hormone_binding_globulin	54,82	tamoxifen	sex hormone binding globulin	MESH:D013629	6462	Chemical	Gene	therapy|nmod|START_ENTITY therapy|dep|effects effects|nmod|END_ENTITY	Long-term adjuvant therapy with tamoxifen : effects on sex_hormone_binding_globulin and antithrombin III .
2865501	0	tamoxifen	25,34	thyroxin-binding_globulin	55,80	tamoxifen	thyroxin-binding globulin	MESH:D013629	6906	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Oestrogen-like effect of tamoxifen on concentration of thyroxin-binding_globulin .
8508397	0	tamoxifen	55,64	transforming_growth_factor-alpha	19,51	tamoxifen	transforming growth factor-alpha	MESH:D013629	7124	Chemical	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|nmod|END_ENTITY	Down-regulation of transforming_growth_factor-alpha by tamoxifen in human breast_cancer .
10402064	0	tamoxifen	141,150	transforming_growth_factor-beta1	14,46	tamoxifen	transforming growth factor-beta1	MESH:D013629	7040	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of transforming_growth_factor-beta1 gene expression and cell proliferation in human hepatocellular_carcinoma cells -LRB- PLC/PRF/5 -RRB- by tamoxifen .
11056313	0	tamoxifen	71,80	transforming_growth_factor_beta	26,57	tamoxifen	transforming growth factor beta	MESH:D013629	7040	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|END_ENTITY	Modulation of endometrial transforming_growth_factor_beta -LRB- TGFbeta -RRB- by tamoxifen .
8695348	0	tamoxifen	156,165	transforming_growth_factor_beta	27,58	tamoxifen	transforming growth factor beta	MESH:D013629	7040	Chemical	Gene	isoforms|nmod|START_ENTITY isoforms|nsubj|Synthesis Synthesis|nmod|END_ENTITY	Synthesis and secretion of transforming_growth_factor_beta isoforms by primary cultures of human breast_tumour fibroblasts in vitro and their modulation by tamoxifen .
8695368	0	tamoxifen	94,103	transforming_growth_factor_beta	25,56	tamoxifen	transforming growth factor beta	MESH:D013629	7040	Chemical	Gene	therapy|compound|START_ENTITY undergoing|dobj|therapy patients|acl|undergoing isoforms|nmod|patients isoforms|nsubj|Changes Changes|nmod|expression expression|nmod|mRNA mRNA|compound|END_ENTITY	Changes in expression of transforming_growth_factor_beta mRNA isoforms in patients undergoing tamoxifen therapy .
11368663	0	tamoxifen	10,19	transforming_growth_factor_beta1	23,55	tamoxifen	transforming growth factor beta1	MESH:D013629	7040	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|production production|amod|END_ENTITY	Effect of tamoxifen on transforming_growth_factor_beta1 production by keloid and fetal fibroblasts .
12684392	0	tamoxifen	86,95	vascular_endothelial_growth_factor	9,43	tamoxifen	vascular endothelial growth factor	MESH:D013629	7422	Chemical	Gene	therapy|compound|START_ENTITY predicts|nmod|therapy predicts|nsubj|END_ENTITY	Combined vascular_endothelial_growth_factor and TP53 status predicts poor response to tamoxifen therapy in estrogen_receptor-positive advanced_breast_cancer .
12771461	0	tamoxifen	52,61	vascular_endothelial_growth_factor	14,48	tamoxifen	vascular endothelial growth factor	MESH:D013629	7422	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of vascular_endothelial_growth_factor by tamoxifen in vitro and in vivo .
15640959	0	tamoxifen	210,219	vascular_endothelial_growth_factor	79,113	tamoxifen	vascular endothelial growth factor	MESH:D013629	7422	Chemical	Gene	transforming|nmod|START_ENTITY alterations|acl|transforming alterations|amod|END_ENTITY	Early nuclear alterations and immunohistochemical expression of Ki-67 , Erb-B2 , vascular_endothelial_growth_factor -LRB- VEGF -RRB- , transforming growth factor -LRB- TGF-beta1 -RRB- and integrine-linked kinase -LRB- ILK -RRB- two days after tamoxifen in breast_carcinoma .
17564928	0	tamoxifen	78,87	vascular_endothelial_growth_factor	14,48	tamoxifen	vascular endothelial growth factor	MESH:D013629	7422	Chemical	Gene	edema|compound|START_ENTITY therapy|nmod|edema inhibitor|dobj|therapy inhibitor|nsubj|END_ENTITY	Intravitreous vascular_endothelial_growth_factor -LRB- VEGF -RRB- inhibitor therapy for tamoxifen induced macular edema .
20846715	0	tamoxifen	30,39	vascular_endothelial_growth_factor	264,298	tamoxifen	vascular endothelial growth factor	MESH:D013629	7422	Chemical	Gene	trial|nmod|START_ENTITY _|nsubj|trial _|nmod|evaluation evaluation|nmod|END_ENTITY	Randomized phase III trial of tamoxifen versus thalidomide in women with biochemical-recurrent-only epithelial ovarian , _ fallopian_tube_or_primary_peritoneal_carcinoma after a complete response to first-line platinum/taxane chemotherapy with an evaluation of serum vascular_endothelial_growth_factor -LRB- VEGF -RRB- : A Gynecologic Oncology Group Study .
23212665	0	tamoxifen	10,19	vascular_endothelial_growth_factor	153,187	tamoxifen	vascular endothelial growth factor	MESH:D013629	7422	Chemical	Gene	methoxyprogesterone_acetate|compound|START_ENTITY treatment|compound|methoxyprogesterone_acetate Effect|nmod|treatment Effect|nmod|cells cells|nmod|regulation regulation|nmod|END_ENTITY	Effect of tamoxifen , methoxyprogesterone_acetate and combined treatment on cellular proliferation and apoptosis in SKOV3/DDP cells via the regulation of vascular_endothelial_growth_factor .
10503165	0	tamsulosin	173,183	alpha_1A-adrenoceptor	51,72	tamsulosin	alpha 1A-adrenoceptor	MESH:C088482	148	Chemical	Gene	studies|nmod|START_ENTITY comparison|dep|studies comparison|nmod|antagonists antagonists|amod|END_ENTITY	Clinical comparison of selective and non-selective alpha_1A-adrenoceptor antagonists for bladder_outlet_obstruction associated with benign_prostatic_hyperplasia : studies on tamsulosin and terazosin in Chinese patients .
9352698	0	tamsulosin	51,61	alpha_1A-adrenoceptor	92,113	tamsulosin	alpha 1A-adrenoceptor	MESH:C088482	148	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	A dose-ranging study of the efficacy and safety of tamsulosin , the first prostate-selective alpha_1A-adrenoceptor antagonist , in patients with benign_prostatic_obstruction -LRB- symptomatic benign_prostatic_hyperplasia -RRB- .
9352700	0	tamsulosin	131,141	alpha_1A-adrenoreceptor	51,74	tamsulosin	alpha 1A-adrenoreceptor	MESH:C088482	148	Chemical	Gene	studies|nmod|START_ENTITY comparison|dep|studies comparison|nmod|antagonists antagonists|amod|END_ENTITY	Clinical comparison of selective and non-selective alpha_1A-adrenoreceptor antagonists in benign_prostatic_hyperplasia : studies on tamsulosin in a fixed dose and terazosin in increasing doses .
18583890	0	tamsulosin	98,108	prostate-specific_antigen	119,144	tamsulosin	prostate-specific antigen	MESH:C088482	354	Chemical	Gene	derivative|appos|START_ENTITY derivative|nmod|END_ENTITY	Impacts of the quinazoline-based alpha1-antagonist , terazosin , and of the sulfonamide derivative , tamsulosin , on serum prostate-specific_antigen and prostate volume .
20538320	0	tamsulosin	45,55	prostate-specific_antigen	13,38	tamsulosin	prostate-specific antigen	MESH:C088482	354	Chemical	Gene	treatment|compound|START_ENTITY END_ENTITY|nmod|treatment	Reduction of prostate-specific_antigen after tamsulosin treatment in patients with elevated prostate-specific_antigen and lower urinary tract symptoms associated with low incidence of prostate_cancer at biopsy .
20538320	0	tamsulosin	45,55	prostate-specific_antigen	92,117	tamsulosin	prostate-specific antigen	MESH:C088482	354	Chemical	Gene	treatment|compound|START_ENTITY treatment|nmod|patients patients|nmod|END_ENTITY	Reduction of prostate-specific_antigen after tamsulosin treatment in patients with elevated prostate-specific_antigen and lower urinary tract symptoms associated with low incidence of prostate_cancer at biopsy .
11489272	0	tandospirone	22,34	5-HT1A	38,44	tandospirone	5-HT1A	MESH:C055267	24473(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Inhibitory effects of tandospirone , a 5-HT1A agonist , on medial vestibular nucleus neurons responding to lateral roll tilt stimulation in rats .
18408919	0	tandospirone	36,48	5-HT1A	21,27	tandospirone	5-HT1A	MESH:C055267	3350	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|agonist agonist|amod|END_ENTITY	Effects of selective 5-HT1A agonist tandospirone on the rate and rhythmicity of binocular rivalry .
9201724	0	tandospirone	104,116	5-HT1A	88,94	tandospirone	5-HT1A	MESH:C055267	24473(Tax:10116)	Chemical	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|novel novel|dep|END_ENTITY	-LSB- A new approach to innovating selective anxiolytics : pharmacological profile of a novel 5-HT1A agonist -LRB- tandospirone -RRB- -RSB- .
16902153	0	tandutinib	30,40	FLT3	59,63	tandutinib	FLT3	MESH:C464670	2322	Chemical	Gene	results|nmod|START_ENTITY results|appos|antagonist antagonist|compound|END_ENTITY	Phase 1 clinical results with tandutinib -LRB- MLN518 -RRB- , a novel FLT3 antagonist , in patients with acute_myelogenous_leukemia or high-risk myelodysplastic_syndrome : safety , pharmacokinetics , and pharmacodynamics .
21594721	0	tanespimycin	77,89	cytochrome_P450	23,38	tanespimycin	cytochrome P450	MESH:C112765	4051	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	In vitro assessment of cytochrome_P450 inhibition and induction potential of tanespimycin and its major metabolite , 17-amino-17-demethoxygeldanamycin .
3920681	0	tannic_acid	22,33	lipoxygenase	62,74	tannic acid	lipoxygenase	null	547836(Tax:3847)	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nsubj|effects	Inhibitory effects of tannic_acid and benzophenone on soybean lipoxygenase and ram seminal vesicle cyclooxygenase .
15194503	0	tannin	22,28	salivary_alpha-amylase	38,60	tannin	salivary alpha-amylase	CHEBI:26848	276	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Inhibitory effects of tannin on human salivary_alpha-amylase .
3033368	0	tannins	32,39	angiotensin_converting_enzyme	43,72	tannins	angiotensin converting enzyme	null	1636	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Inhibitory effects of condensed tannins on angiotensin_converting_enzyme .
26456030	0	tanshinone	22,32	a-synuclein	55,66	tanshinone	a-synuclein	MESH:C021751	6622	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|aggregation aggregation|nmod|END_ENTITY	Inhibition effects of tanshinone on the aggregation of a-synuclein .
12753423	0	tanshinone_I	26,38	cytochrome_c	43,55	tanshinone I	cytochrome c	MESH:C021751	54205	Chemical	Gene	START_ENTITY|nmod|release release|amod|END_ENTITY	Induction of apoptosis by tanshinone_I via cytochrome_c release in activated hepatic stellate cells .
17303087	0	tanshinone_IIA	34,48	Nrf2	0,4	tanshinone IIA	Nrf2	MESH:C021751	4780	Chemical	Gene	effect|nmod|START_ENTITY involved|nmod|effect involved|nsubjpass|END_ENTITY	Nrf2 is involved in the effect of tanshinone_IIA on intracellular redox status in human aortic smooth muscle cells .
19662366	0	tanshinone_IIA	14,28	TGF-beta1	38,47	tanshinone IIA	TGF-beta1	MESH:C021751	59086(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of tanshinone_IIA upon the TGF-beta1 / Smads signaling pathway in hypertrophic_myocardium of hypertensive rats .
24491056	0	tanshinone_IIA	12,26	caspase-3	49,58	tanshinone IIA	caspase-3	MESH:C021751	25402(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expressions expressions|nmod|END_ENTITY	-LSB- Effects of tanshinone_IIA on the expressions of caspase-3 , Akt and NF-kB in the brains of rat models of Alzheimer 's _ disease -RSB- .
26643424	0	tanshinone_IIA	12,26	p53	49,52	tanshinone IIA	p53	MESH:C021751	301300(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expressions expressions|nmod|END_ENTITY	-LSB- Effects of tanshinone_IIA on the expressions of p53 , pp53 and apoptosis in the rats with Alzheimer 's _ disease -RSB- .
21287782	0	tanshinone_IIA	68,82	prohibitin	86,96	tanshinone IIA	prohibitin	MESH:C021751	25344(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Study of anti-myocardial cell oxidative stress action and effect of tanshinone_IIA on prohibitin expression .
24200061	0	tanshinone_II_A	11,26	NeuN	49,53	tanshinone II A	NeuN	MESH:C021751	287847(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expressions expressions|nmod|END_ENTITY	-LSB- Effect of tanshinone_II_A on the expressions of NeuN , GFAP and CD11b in Ab1-42 ; induced newborn rat hippocampal slices in vitro -RSB- .
21722522	0	tanshinone_II_A	11,26	TLR4	30,34	tanshinone II A	TLR4	MESH:C021751	7099	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of tanshinone_II_A on TLR4 and TNF-a of endothelial cells induced by LPS -RSB- .
18076874	0	tanshinone_VI	11,24	ERK	47,50	tanshinone VI	ERK	MESH:C090979	24338(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of tanshinone_VI on phosphorylation of ERK and Akt in isolated cardiomyocytes and cardiac fibroblasts .
21262326	0	tanshinones	21,32	CYP3A2	40,46	tanshinones	CYP3A2	null	266682(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Inhibitory effect of tanshinones on rat CYP3A2 and CYP2C11 activity and its structure-activity relationship .
21787715	0	tanshinones	113,124	acetylcholinesterase	132,152	tanshinones	acetylcholinesterase	null	83817(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	In Salvia miltiorrhiza , phenolic_acids possess protective properties against amyloid b-induced cytotoxicity , and tanshinones act as acetylcholinesterase inhibitors .
12214853	0	tanshinones	57,68	diacylglycerol_acyltransferase	23,53	tanshinones	diacylglycerol acyltransferase	null	84497(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|nmod|END_ENTITY	Inhibitory activity of diacylglycerol_acyltransferase by tanshinones from the root of Salvia miltiorrhiza .
22556245	0	tantalum	57,65	spin	37,41	tantalum	spin	MESH:D013635	10927	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|dobj|effect	Spin-torque switching with the giant spin Hall effect of tantalum .
18936284	0	taranabant	13,23	CB1R	92,96	taranabant	CB1R	MESH:C521311	1268	Chemical	Gene	START_ENTITY|appos|agonist agonist|appos|END_ENTITY	Influence of taranabant , an orally active , highly selective , potent cannabinoid-1_receptor -LRB- CB1R -RRB- inverse agonist , on ethinyl_estradiol and norelgestromin plasma pharmacokinetics .
18936284	0	taranabant	13,23	cannabinoid-1_receptor	68,90	taranabant	cannabinoid-1 receptor	MESH:C521311	1268	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Influence of taranabant , an orally active , highly selective , potent cannabinoid-1_receptor -LRB- CB1R -RRB- inverse agonist , on ethinyl_estradiol and norelgestromin plasma pharmacokinetics .
24945401	0	taraxasterol	11,23	iNOS	27,31	taraxasterol	iNOS	MESH:C079988	18126(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of taraxasterol on iNOS and COX-2 expression in LPS-induced RAW 264.7 macrophages .
19591692	0	tariquidar	48,58	ABCB1	22,27	tariquidar	ABCB1	MESH:C402343	18669(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Influence Influence|nmod|END_ENTITY	Influence of the dual ABCB1 and ABCG2 inhibitor tariquidar on the disposition of oral imatinib in mice .
15986399	0	tariquidar	18,28	P-glycoprotein	42,56	tariquidar	P-glycoprotein	MESH:C402343	5243	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Phase II study of tariquidar , a selective P-glycoprotein inhibitor , in patients with chemotherapy-resistant , advanced breast_carcinoma .
19417029	0	tariquidar	49,59	P-glycoprotein	23,37	tariquidar	P-glycoprotein	MESH:C402343	5243	Chemical	Gene	START_ENTITY|nsubj|study study|nmod|antagonist antagonist|amod|END_ENTITY	A phase I study of the P-glycoprotein antagonist tariquidar in combination with vinorelbine .
19910428	0	tariquidar	40,50	P-glycoprotein	62,76	tariquidar	P-glycoprotein	MESH:C402343	5243	Chemical	Gene	efficacy|nmod|START_ENTITY assess|dobj|efficacy assess|advcl|inhibit inhibit|dobj|END_ENTITY	A pilot study to assess the efficacy of tariquidar to inhibit P-glycoprotein at the human blood-brain barrier with -LRB- R -RRB- -11 C-verapamil and PET .
21081657	0	tariquidar	87,97	P-glycoprotein	61,75	tariquidar	P-glycoprotein	MESH:C402343	5243	Chemical	Gene	START_ENTITY|amod|docetaxel docetaxel|nmod|combination combination|nmod|antagonist antagonist|amod|END_ENTITY	A pharmacodynamic study of docetaxel in combination with the P-glycoprotein antagonist tariquidar -LRB- XR9576 -RRB- in patients with lung , _ ovarian , _ and_cervical_cancer .
26486517	0	tariquidar	45,55	P-glycoprotein	68,82	tariquidar	P-glycoprotein	MESH:C402343	5243	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Pharmacokinetic and pharmacodynamic study of tariquidar -LRB- XR9576 -RRB- , a P-glycoprotein inhibitor , in combination with doxorubicin , vinorelbine , or docetaxel in children and adolescents with refractory solid tumors .
23374872	0	tariquidar	21,31	P-gp	86,90	tariquidar	P-gp	MESH:C402343	283871	Chemical	Gene	bioisosters|compound|START_ENTITY radiotracers|nsubj|bioisosters radiotracers|nmod|END_ENTITY	Potent and selective tariquidar bioisosters as potential PET radiotracers for imaging P-gp .
26197160	0	tariquidar	42,52	P-gp	12,16	tariquidar	P-gp	MESH:C402343	283871	Chemical	Gene	derivatives|compound|START_ENTITY MDR|nmod|derivatives MDR|nsubj|Reversal Reversal|nmod|END_ENTITY	Reversal of P-gp and BCRP-mediated MDR by tariquidar derivatives .
26197160	0	tariquidar	42,52	P-gp	12,16	tariquidar	P-gp	MESH:C402343	283871	Chemical	Gene	derivatives|compound|START_ENTITY MDR|nmod|derivatives MDR|nsubj|Reversal Reversal|nmod|END_ENTITY	Reversal of P-gp and BCRP-mediated MDR by tariquidar derivatives .
26454782	0	tariquidar	77,87	P-gp	56,60	tariquidar	P-gp	MESH:C402343	287115(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	5-HT2A receptor SPECT imaging with -LSB- -LRB- 123 -RRB- I -RSB- R91150 under P-gp inhibition with tariquidar : More is better ?
19170519	0	tariquidar	126,136	breast_cancer_resistance_protein	35,67	tariquidar	breast cancer resistance protein	MESH:C402343	9429	Chemical	Gene	derived|nmod|START_ENTITY derived|nsubj|inhibitors inhibitors|nmod|END_ENTITY	Potent and selective inhibitors of breast_cancer_resistance_protein -LRB- ABCG2 -RRB- derived from the p-glycoprotein -LRB- ABCB1 -RRB- modulator tariquidar .
17881135	0	tariquidar	74,84	p-gp	54,58	tariquidar	MDR1	MESH:C402343	18669(Tax:10090)	Chemical	Gene	impacts|compound|START_ENTITY inhibition|nmod|impacts inhibition|nsubj|p-glycoprotein p-glycoprotein|appos|END_ENTITY	Multidrug-resistance gene 1-type p-glycoprotein -LRB- MDR1 p-gp -RRB- inhibition by tariquidar impacts on neuroendocrine and behavioral processing of stress .
1905021	0	tarsioids	19,28	Involucrin	0,10	tarsioids	Involucrin	null	3713	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Involucrin gene of tarsioids and other primates : alternatives in evolution of the segment of repeats .
21458257	0	tartrate_diamides	41,58	TACE	104,108	tartrate diamides	TACE	null	57027(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	2 - -LRB- 2-Aminothiazol-4-yl -RRB- pyrrolidine-based tartrate_diamides as potent , selective and orally bioavailable TACE inhibitors .
23270402	0	taspine	34,41	EGFR	72,76	taspine	EGFR	MESH:C018394	1956	Chemical	Gene	START_ENTITY|xcomp|binding binding|nmod|END_ENTITY	Rapid characterization of a novel taspine derivative-HMQ1611 binding to EGFR by a cell membrane chromatography method .
19929995	0	taspoglutide	50,62	GLP-1	85,90	taspoglutide	GLP-1	MESH:C541736	2641	Chemical	Gene	START_ENTITY|appos|analogue analogue|compound|END_ENTITY	Pharmacokinetic and pharmacodynamic properties of taspoglutide , a once-weekly , human GLP-1 analogue , after single-dose administration in patients with Type 2 diabetes .
23139373	0	taspoglutide	12,24	GLP-1_receptor	35,49	taspoglutide	GLP-1 receptor	MESH:C541736	2740	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	The fate of taspoglutide , a weekly GLP-1_receptor agonist , versus twice-daily exenatide for type 2 diabetes : the T-emerge 2 trial .
23911196	0	taspoglutide	71,83	GLP-1_receptor	46,60	taspoglutide	GLP-1 receptor	MESH:C541736	2740	Chemical	Gene	agonists|dep|START_ENTITY agonists|compound|END_ENTITY	A direct comparison of long - and short-acting GLP-1_receptor agonists -LRB- taspoglutide once weekly and exenatide twice daily -RRB- on postprandial metabolism after 24 weeks of treatment .
7972031	4	tau	509,512	apoE3	529,534	tau	ApoE3	CHEBI:36355	348	Chemical	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	In vitro , tau binds avidly to apoE3 , but not to apoE4 , forming a bimolecular complex .
9176135	0	taurine	47,54	AE1	16,19	taurine	AE1	MESH:D013654	24779(Tax:10116)	Chemical	Gene	transport|amod|START_ENTITY END_ENTITY|nmod|transport	Anion exchanger AE1 as a candidate pathway for taurine transport in rat erythrocytes .
22130357	0	taurine	14,21	Akt	63,66	taurine	Akt	MESH:D013654	11651(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dep|END_ENTITY	Extracellular taurine induces angiogenesis by activating ERK - , Akt - , and FAK-dependent signal pathways .
15235873	0	taurine	43,50	CCl4	101,105	taurine	CCl4	MESH:D013654	116637(Tax:10116)	Chemical	Gene	concentration|amod|START_ENTITY reducing|dobj|concentration exercise|acl|reducing effect|nmod|exercise effect|acl|treated treated|nmod|administration administration|amod|END_ENTITY	The harmful effect of exercise on reducing taurine concentration in the tissues of rats treated with CCl4 administration .
18756597	0	taurine	45,52	CCl4	66,70	taurine	CCl4	MESH:D013654	116637(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|END_ENTITY	Ultrastructural changes in hepatocytes after taurine treatment in CCl4 induced liver_injury .
20827495	0	taurine	14,21	CK2	52,55	taurine	CK2	MESH:D013654	13000(Tax:10090)	Chemical	Gene	Regulation|nmod|START_ENTITY homeostasis|nsubj|Regulation homeostasis|nmod|END_ENTITY	Regulation of taurine homeostasis by protein kinase CK2 in mouse fibroblasts .
20113662	0	taurine	21,28	CREB	55,59	taurine	CREB	MESH:D013654	81646(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of prenatal taurine on mRNA expression of PKA CREB signal pathway and glial_cell_line_derived_neurotrophic_factor in fetal rat brains of intrauterine_growth_restriction -RSB- .
19921479	0	taurine	52,59	CSD	0,3	taurine	CSD	MESH:D013654	60356(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	CSD mRNA expression in rat testis and the effect of taurine on testosterone secretion .
16151615	0	taurine	20,27	CYP7A1	31,37	taurine	CYP7A1	MESH:D013654	1581	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Enhancing effect of taurine on CYP7A1 mRNA expression in Hep G2 cells .
2352190	0	taurine	15,22	Ca2	26,29	taurine	Ca2	MESH:D013654	54231(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|+ +|amod|END_ENTITY	The effects of taurine on Ca2 + uptake by the sarcoplasmic reticulum and Ca2 + sensitivity of chemically skinned rat heart .
200271	0	taurine	75,82	Myeloperoxidase	0,15	taurine	Myeloperoxidase	MESH:D013654	4353	Chemical	Gene	inactivation|nmod|START_ENTITY inactivation|amod|END_ENTITY	Myeloperoxidase inactivation in the course of catalysis of chlorination of taurine .
16598948	0	taurine	12,19	NOS	44,47	taurine	NOS	MESH:D013654	18125(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	-LSB- Effects of taurine and zinc on activity of NOS and expression of nNOS in cerebral cortex of acute hypoxic mice -RSB- .
12681485	0	taurine	14,21	TauT	40,44	taurine	TauT	MESH:D013654	6533	Chemical	Gene	gene|amod|START_ENTITY Regulation|nmod|gene Regulation|appos|END_ENTITY	Regulation of taurine transporter gene -LRB- TauT -RRB- by WT1 .
21488091	0	taurine	59,66	calbindin-d28k	12,26	taurine	calbindin-d28k	MESH:D013654	12307(Tax:10090)	Chemical	Gene	treatment|amod|START_ENTITY END_ENTITY|nmod|treatment	Decrease of calbindin-d28k , calretinin , and parvalbumin by taurine treatment does not induce a major susceptibility to kainic_acid .
16338968	0	taurine	65,72	caveolin-1	15,25	taurine	caveolin-1	MESH:D013654	857	Chemical	Gene	release|nmod|START_ENTITY END_ENTITY|nmod|release	Stimulation by caveolin-1 of the hypotonicity-induced release of taurine and ATP at basolateral , but not apical , membrane of Caco-2 cells .
16601146	1	taurine	103,110	caveolin-1	53,63	taurine	caveolin-1	MESH:D013654	857	Chemical	Gene	release|nmod|START_ENTITY END_ENTITY|nmod|release	Focus on `` Stimulation by caveolin-1 of the hypotonicity-induced release of taurine and ATP at basolateral , but not apical , membrane of Caco-2 cells '' .
3668703	0	taurine	18,25	cholesterol_7_alpha-hydroxylase	29,60	taurine	cholesterol 7 alpha-hydroxylase	MESH:D013654	13122(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effect of dietary taurine on cholesterol_7_alpha-hydroxylase activity in the liver of mice fed a lithogenic diet .
10737200	0	taurine	29,36	cytochrome_P-450	57,73	taurine	cytochrome P-450	MESH:D013654	25251(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|induction induction|nmod|END_ENTITY	Amplifying effect of dietary taurine on the induction of cytochrome_P-450 and on the urinary excretion of ascorbic_acid in rats fed on phenobarbital-containing diets .
20166895	0	taurine	102,109	cytochrome_P450_2E1	132,151	taurine	cytochrome P450 2E1	MESH:D013654	1571	Chemical	Gene	START_ENTITY|nmod|suppression suppression|nmod|END_ENTITY	Acetaminophen induced acute_liver_failure via oxidative stress and JNK activation : protective role of taurine by the suppression of cytochrome_P450_2E1 .
3412107	0	taurine	10,17	growth_hormone	21,35	taurine	growth hormone	MESH:D013654	81668(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Effect of taurine on growth_hormone and prolactin secretion in rats : possible interaction with opioid peptidergic system .
647491	0	taurine	14,21	growth_hormone	42,56	taurine	growth hormone	MESH:D013654	2688	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Antagonism by taurine of morphine induced growth_hormone secretion .
25604803	0	taurine	21,28	lysozyme	78,86	taurine	lysozyme	MESH:D013654	4069	Chemical	Gene	Role|nmod|START_ENTITY Role|amod|END_ENTITY	Role of the osmolyte taurine on the folding of a model protein , hen egg white lysozyme , under a crowding condition .
14724063	0	taurine	190,197	prolactin	11,20	taurine	prolactin	MESH:D013654	24683(Tax:10116)	Chemical	Gene	dopamine|dep|START_ENTITY Changes|nmod|dopamine Changes|nmod|mechanisms mechanisms|amod|END_ENTITY	Changes of prolactin regulatory mechanisms in aging : 24-h rhythms of serum prolactin and median eminence and adenohypophysial concentration of dopamine , serotonin , -LRB- gamma-aminobutyric_acid , taurine and somatostatin in young and aged rats .
2813286	0	taurine	46,53	prolactin	85,94	taurine	prolactin	MESH:D013654	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Comparison of the effects of intraventricular taurine , GABA and homotaurine on serum prolactin levels in male rats .
3109888	0	taurine	76,83	prolactin	134,143	taurine	prolactin	MESH:D013654	24683(Tax:10116)	Chemical	Gene	compounds|dobj|START_ENTITY compounds|nmod|levels levels|compound|END_ENTITY	The effect of cysteamine , cystamine , and the structurally related compounds taurine , N-acetyl-cysteine , and D-penicillamine on plasma prolactin levels in normal and estrogen-primed hyperprolactinemic rats .
6478270	0	taurine	42,49	prolactin	19,28	taurine	prolactin	MESH:D013654	5617	Chemical	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	The stimulation of prolactin secretion by taurine : studies on the site of action .
7383274	0	taurine	38,45	prolactin	15,24	taurine	prolactin	MESH:D013654	24683(Tax:10116)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Stimulation of prolactin secretion by taurine , a neurally depressant amino_acid .
22960072	0	taurine	10,17	thioredoxin_interacting_protein	40,71	taurine	thioredoxin interacting protein	MESH:D013654	10628	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	Effect of taurine on mRNA expression of thioredoxin_interacting_protein in Caco-2 cells .
9490651	0	taurine	66,73	transforming_growth_factor-beta1	14,46	taurine	transforming growth factor-beta1	MESH:D013654	7040	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of transforming_growth_factor-beta1 mRNA expression by taurine and niacin in the bleomycin hamster model of lung_fibrosis .
18219551	0	taurine_chloramine	67,85	Heme_oxygenase-1	0,16	taurine chloramine	Heme oxygenase-1	MESH:C043410	3162	Chemical	Gene	activity|nmod|START_ENTITY participates|nmod|activity participates|nsubj|END_ENTITY	Heme_oxygenase-1 participates in the anti-inflammatory activity of taurine_chloramine .
18157587	0	taurine_chloramine	70,88	heme_oxygenase-1	12,28	taurine chloramine	heme oxygenase-1	MESH:C043410	15368(Tax:10090)	Chemical	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	The role of heme_oxygenase-1 in down regulation of PGE2 production by taurine_chloramine and taurine_bromamine in J774 .2 macrophages .
23395169	0	tauro-beta-muricholic_acid	72,98	FXR	122,125	tauro-beta-muricholic acid	FXR	MESH:C037351	20186(Tax:10090)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Gut microbiota regulates bile_acid metabolism by reducing the levels of tauro-beta-muricholic_acid , a naturally occurring FXR antagonist .
7810656	0	taurocholate	34,46	Interleukin-6	0,13	taurocholate	Interleukin-6	MESH:D013656	3569	Chemical	Gene	uptake|compound|START_ENTITY inhibits|dobj|uptake inhibits|nsubj|END_ENTITY	Interleukin-6 inhibits hepatocyte taurocholate uptake and sodium-potassium-adenosinetriphosphatase activity .
21945488	0	taurocholate	66,78	NTCP	107,111	taurocholate	NTCP	MESH:D013656	6554	Chemical	Gene	polypeptide|amod|START_ENTITY polypeptide|appos|END_ENTITY	Interaction of fluvastatin with the liver-specific Na + - dependent taurocholate cotransporting polypeptide -LRB- NTCP -RRB- .
9038875	0	taurocholate	34,46	Prolactin	0,9	taurocholate	Prolactin	MESH:D013656	24683(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY increases|dobj|transport increases|nsubj|END_ENTITY	Prolactin increases ATP-dependent taurocholate transport in canalicular plasma membrane from rat liver .
14729072	0	taurocholate	44,56	apolipoprotein_B	14,30	taurocholate	apolipoprotein B	MESH:D013656	54225(Tax:10116)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|amod|END_ENTITY	Inhibition of apolipoprotein_B secretion by taurocholate is controlled by the N-terminal end of the protein in rat hepatoma McArdle-RH7777 cells .
1619360	2	taurocholate	74,86	cholesterol_7_alpha-hydroxylase	39,70	taurocholate	cholesterol 7 alpha-hydroxylase	MESH:D013656	25428(Tax:10116)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of cholesterol_7_alpha-hydroxylase by taurocholate and mevalonate .
1995604	0	taurocholate	83,95	cholesterol_7_alpha-hydroxylase	14,45	taurocholate	cholesterol 7 alpha-hydroxylase	MESH:D013656	25428(Tax:10116)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|mRNA mRNA|amod|END_ENTITY	Regulation of cholesterol_7_alpha-hydroxylase mRNA and transcriptional activity by taurocholate and cholesterol in the chronic biliary diverted rat .
7835596	0	taurocholate	35,47	cholesterol_7_alpha-hydroxylase	65,96	taurocholate	cholesterol 7 alpha-hydroxylase	MESH:D013656	25428(Tax:10116)	Chemical	Gene	infusion|nmod|START_ENTITY Failure|nmod|infusion Failure|acl|down-regulate down-regulate|xcomp|END_ENTITY	Failure of intravenous infusion of taurocholate to down-regulate cholesterol_7_alpha-hydroxylase in rats with biliary_fistulas .
24970118	0	taurocholic_acid	79,95	OATP1A2	68,75	taurocholic acid	OATP1A2	MESH:D013656	6579	Chemical	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Molecular regulation of organic_anion_transporting_polypeptide_1A2 -LRB- OATP1A2 -RRB- by taurocholic_acid in Bewo Cells .
21464203	0	taurocholic_acid	96,112	apoA-I	75,81	taurocholic acid	apoA-I	MESH:D013656	25081(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Studies in mice , hamsters , and rats demonstrate that repression of hepatic apoA-I expression by taurocholic_acid in mice is not mediated by the farnesoid-X-receptor .
23181598	0	taurocholic_acid	36,52	glucagon-like_peptide-1	56,79	taurocholic acid	glucagon-like peptide-1	MESH:D013656	2641	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|amod|END_ENTITY	Effects of rectal administration of taurocholic_acid on glucagon-like_peptide-1 and peptide_YY secretion in healthy humans .
24970118	0	taurocholic_acid	79,95	organic_anion_transporting_polypeptide_1A2	24,66	taurocholic acid	organic anion transporting polypeptide 1A2	MESH:D013656	6579	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Molecular regulation of organic_anion_transporting_polypeptide_1A2 -LRB- OATP1A2 -RRB- by taurocholic_acid in Bewo Cells .
21276943	0	tautomycetin	42,54	SHP2	0,4	tautomycetin	SHP2	MESH:C058744	5781	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	SHP2 is a target of the immunosuppressant tautomycetin .
22194527	0	taxane	50,56	TLE3	0,4	taxane	TLE3	MESH:C080625	7090	Chemical	Gene	associated|xcomp|START_ENTITY associated|nsubjpass|expression expression|compound|END_ENTITY	TLE3 expression is associated with sensitivity to taxane treatment in ovarian_carcinoma .
21570352	0	taxane	45,51	TP53	0,4	taxane	TP53	MESH:C080625	7157	Chemical	Gene	status|acl|START_ENTITY status|nummod|END_ENTITY	TP53 status for prediction of sensitivity to taxane versus non-taxane neoadjuvant chemotherapy in breast_cancer -LRB- EORTC 10994/BIG 1-00 -RRB- : a randomised phase 3 trial .
15901996	0	taxane	127,133	c-erbB-2	176,184	taxane	c-erbB-2	MESH:C080625	2064	Chemical	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	Exogenous supplementation with omega-3_polyunsaturated_fatty_acid docosahexaenoic_acid -LRB- DHA ; 22:6 n-3 -RRB- synergistically enhances taxane cytotoxicity and downregulates Her-2 / neu -LRB- c-erbB-2 -RRB- oncogene expression in human breast_cancer cells .
7915279	0	taxanes	38,45	C-10	49,53	taxanes	C-10	MESH:D043823	3226	Chemical	Gene	hydrolysis|nmod|START_ENTITY hydrolysis|nmod|END_ENTITY	Site-specific enzymatic hydrolysis of taxanes at C-10 and C-13 .
23672670	0	taxanes	49,56	Caspase-2	0,9	taxanes	Caspase-2	MESH:D043823	835	Chemical	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	Caspase-2 is involved in cell death induction by taxanes in breast_cancer cells .
15849751	0	taxanes	24,31	MRP2	0,4	taxanes	MRP2	MESH:D043823	1244	Chemical	Gene	transports|dobj|START_ENTITY transports|nsubj|END_ENTITY	MRP2 -LRB- ABCC2 -RRB- transports taxanes and confers paclitaxel resistance and both processes are stimulated by probenecid .
26499946	0	taxanes	92,99	a7-nicotinic_acetylcholine_receptor	4,39	taxanes	a7-nicotinic acetylcholine receptor	MESH:D043823	1139	Chemical	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	The a7-nicotinic_acetylcholine_receptor mediates the sensitivity of gastric_cancer cells to taxanes .
19461204	0	taxol	62,67	Bcl-xL	12,18	taxol	Bcl-xL	MESH:D017239	598	Chemical	Gene	effect|nmod|START_ENTITY role|nmod|effect role|nmod|END_ENTITY	The role of Bcl-xL and nuclear_factor-kappaB in the effect of taxol on the viability of dendritic cells .
7529746	0	taxol	141,146	CD14	0,4	taxol	CD14	MESH:D017239	12475(Tax:10090)	Chemical	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	CD14 is not involved in Rhodobacter_sphaeroides diphosphoryl_lipid_A inhibition of tumor_necrosis_factor_alpha and nitric_oxide induction by taxol in murine macrophages .
8763853	0	taxol	19,24	CIP1	86,90	taxol	CIP1	MESH:D017239	1026	Chemical	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	The interaction of taxol and vinblastine with radiation induction of p53 and p21_WAF1 / CIP1 .
16112667	0	taxol	82,87	E-cadherin	19,29	taxol	E-cadherin	MESH:D017239	999	Chemical	Gene	resistant|nmod|START_ENTITY renders|xcomp|resistant renders|nsubj|Loss Loss|nmod|END_ENTITY	Loss of functional E-cadherin renders cells more resistant to the apoptotic agent taxol in vitro .
16287090	0	taxol	112,117	JNK	140,143	taxol	JNK	MESH:D017239	5599	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Inactivation of Id-1 in prostate_cancer cells : A potential therapeutic target in inducing chemosensitization to taxol through activation of JNK pathway .
21978935	0	taxol	69,74	Plk1	49,53	taxol	Plk1	MESH:D017239	5347	Chemical	Gene	response|nmod|START_ENTITY END_ENTITY|nmod|response	Cooperative phosphorylation of FADD by Aur-A and Plk1 in response to taxol triggers both apoptotic and necrotic cell death .
1674704	0	taxol	29,34	Prothrombinase	0,14	taxol	Prothrombinase	MESH:D017239	2159	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Prothrombinase expression of taxol treated platelets .
19113992	0	taxol	81,86	cyclin_B1	10,19	taxol	cyclin B1	MESH:D017239	891	Chemical	Gene	inhibits|xcomp|START_ENTITY inhibits|nsubj|END_ENTITY	Targeting cyclin_B1 inhibits proliferation and sensitizes breast_cancer cells to taxol .
15012603	0	taxol	67,72	estrogen_receptor-alpha	14,37	taxol	estrogen receptor-alpha	MESH:D017239	2099	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of estrogen_receptor-alpha expression in MCF-7 cells by taxol .
20144215	0	taxol	116,121	lactate_dehydrogenase-A	46,69	taxol	lactate dehydrogenase-A	MESH:D017239	3939	Chemical	Gene	cells|nmod|START_ENTITY cells|amod|END_ENTITY	Warburg effect in chemosensitivity : targeting lactate_dehydrogenase-A re-sensitizes taxol-resistant cancer cells to taxol .
24853425	0	taxol	97,102	mTOR	121,125	taxol	mTOR	MESH:D017239	21977(Tax:10090)	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|END_ENTITY	SPAG5 upregulation predicts poor prognosis in cervical_cancer patients and alters sensitivity to taxol treatment via the mTOR signaling pathway .
22740869	0	taxol	40,45	taxol_resistance_gene_1	63,86	taxol	taxol resistance gene 1	MESH:D017239	54458	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Sensitization of breast_cancer cells to taxol by inhibition of taxol_resistance_gene_1 .
7529746	0	taxol	141,146	tumor_necrosis_factor_alpha	83,110	taxol	tumor necrosis factor alpha	MESH:D017239	21926(Tax:10090)	Chemical	Gene	involved|nmod|START_ENTITY involved|nmod|inhibition inhibition|nmod|induction induction|compound|END_ENTITY	CD14 is not involved in Rhodobacter_sphaeroides diphosphoryl_lipid_A inhibition of tumor_necrosis_factor_alpha and nitric_oxide induction by taxol in murine macrophages .
19246282	0	tazarotene	41,51	MMP-1	55,60	tazarotene	MMP-1	MESH:C086827	4312	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effects of all-trans retinioic_acid and tazarotene on MMP-1 and TIMP-1 expression in cultured human fibroblasts after heat_shock -RSB- .
16939905	0	tazarotene	46,56	promyelocytic_leukemia	15,37	tazarotene	promyelocytic leukemia	MESH:C086827	5371	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	-LSB- Inhibition of promyelocytic_leukemia gene by tazarotene in hyperproliferative epidermis of psoriasis -RSB- .
14521154	0	tea_epigallocatechin-3-gallate	6,36	histidine_decarboxylase	66,89	tea epigallocatechin-3-gallate	histidine decarboxylase	null	3067	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Green tea_epigallocatechin-3-gallate is an inhibitor of mammalian histidine_decarboxylase .
11673766	0	teasaponin	43,53	lipase	57,63	teasaponin	lipase	null	16891(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Anti-obesity effects in rodents of dietary teasaponin , a lipase inhibitor .
2787839	0	teceleukin	20,30	interleukin-2	50,63	teceleukin	interleukin-2	null	3558	Chemical	Gene	Pharmacokinetics|nmod|START_ENTITY Pharmacokinetics|appos|END_ENTITY	Pharmacokinetics of teceleukin -LRB- recombinant human interleukin-2 -RRB- after intravenous or subcutaneous administration to patients with cancer .
12365378	0	technetium	17,27	Leu13	29,34	technetium	Leu13	MESH:D013667	8519	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	Phase I trial of technetium -LSB- Leu13 -RSB- bombesin as cancer seeking agent : possible scintigraphic guide for surgery ?
15546210	0	technetium	20,30	bombesin	43,51	technetium	bombesin	MESH:D013667	2922	Chemical	Gene	analogue|compound|START_ENTITY analogue|nmod|END_ENTITY	A new high affinity technetium analogue of bombesin containing DTPA as a pharmacokinetic modifier .
9476923	0	technetium-99m-MIBI	55,74	P-glycoprotein	94,108	technetium-99m-MIBI	P-glycoprotein	null	5243	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Association of tumor washout rates and accumulation of technetium-99m-MIBI with expression of P-glycoprotein in lung_cancer .
25083589	0	tectochrysin	22,34	STAT3	111,116	tectochrysin	STAT3	MESH:C402729	6774	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Anti-cancer effect of tectochrysin in NSCLC cells through overexpression of death receptor and inactivation of STAT3 .
20931855	0	tectorigenin	11,23	MCP-1	27,32	tectorigenin	MCP-1	MESH:C120039	100360872	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effect of tectorigenin on MCP-1 and ICAM-1 mRNA expression in injured vascular endothelial cells -RSB- .
18974283	0	teduglutide	46,57	GLP-2	86,91	teduglutide	GLP-2	MESH:C494910	2641	Chemical	Gene	START_ENTITY|appos|analog analog|appos|END_ENTITY	Pharmacokinetics , safety , and tolerability of teduglutide , a glucagon-like_peptide-2 -LRB- GLP-2 -RRB- analog , following multiple ascending subcutaneous administrations in healthy subjects .
18974283	0	teduglutide	46,57	glucagon-like_peptide-2	61,84	teduglutide	glucagon-like peptide-2	MESH:C494910	2641	Chemical	Gene	START_ENTITY|appos|analog analog|amod|END_ENTITY	Pharmacokinetics , safety , and tolerability of teduglutide , a glucagon-like_peptide-2 -LRB- GLP-2 -RRB- analog , following multiple ascending subcutaneous administrations in healthy subjects .
1874250	0	teichoic_acid	14,27	Lipase	0,6	teichoic acid	Lipase	CHEBI:30049	17374477	Chemical	Gene	START_ENTITY|nsubj|versus versus|compound|END_ENTITY	Lipase versus teichoic_acid and alpha-toxin as antigen in an enzyme immunoassay for serological diagnosis of Staphylococcus_aureus_infections .
8187790	0	teicoplanin	57,68	interleukin_8	32,45	teicoplanin	interleukin 8	MESH:D017334	3576	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of endotoxin-induced interleukin_8 release by teicoplanin in human whole blood .
24196382	0	telaprevir	36,46	P-glycoprotein	73,87	telaprevir	P-glycoprotein	MESH:C486464	5243	Chemical	Gene	interaction|nmod|START_ENTITY transporters|nsubj|interaction transporters|xcomp|END_ENTITY	Biochemical interaction of anti-HCV telaprevir with the ABC transporters P-glycoprotein and breast_cancer_resistance_protein .
23074230	0	telaprevir	86,96	p-glycoprotein	132,146	telaprevir	p-glycoprotein	MESH:C486464	5243	Chemical	Gene	therapy|nmod|START_ENTITY volunteers|nmod|therapy diameter|nmod|volunteers diameter|dep|interaction interaction|acl|involving involving|dobj|END_ENTITY	Reduced pupil diameter in volunteers on stable buprenorphine maintenance therapy with telaprevir : a drug-drug interaction involving p-glycoprotein at the blood-brain barrier ?
20139142	0	telavancin	12,22	hVISA	92,97	telavancin	hVISA	MESH:C487637	57506	Chemical	Gene	Activity|nmod|START_ENTITY Activity|appos|END_ENTITY	Activity of telavancin against heterogeneous vancomycin-intermediate Staphylococcus_aureus -LRB- hVISA -RRB- in vitro and in an in vivo mouse model of bacteraemia .
19105929	0	telbivudine	15,26	CD4	47,50	telbivudine	CD4	MESH:C487779	920	Chemical	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	-LSB- The effect of telbivudine on peripheral blood CD4 + CD25 + regulatory T cells and its significance in patients with chronic_hepatitis_B -RSB- .
20807412	0	telbivudine	105,116	CD8	47,50	telbivudine	CD8	MESH:C487779	925	Chemical	Gene	treatment|amod|START_ENTITY END_ENTITY|nmod|treatment	Dynamic analysis of CD127 expression on memory CD8 T cells from patients with chronic_hepatitis_B during telbivudine treatment .
2153466	0	teleocidin	24,34	TNF_alpha	38,47	teleocidin	TNF alpha	MESH:C022176	7124	Chemical	Gene	START_ENTITY|nmod|regulation regulation|compound|END_ENTITY	Differential effects of teleocidin on TNF_alpha receptor regulation in human B cell lines : relationship to coexpression of IL-2 and IL-1 receptors and to lymphokine secretion .
17377958	0	telithromycin	143,156	CYP3A1	115,121	telithromycin	CYP3A1	MESH:C106791	25642(Tax:10116)	Chemical	Gene	metabolism|nmod|START_ENTITY END_ENTITY|nmod|metabolism	Effects of acute_renal_failure on the pharmacokinetics of telithromycin in rats : negligible effects of increase in CYP3A1 on the metabolism of telithromycin .
18931390	0	telithromycin	21,34	MUC5AC	38,44	telithromycin	MUC5AC	MESH:C106791	4586	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Different effects of telithromycin on MUC5AC production induced by human neutrophil peptide-1 or lipopolysaccharide in NCI-H292 cells compared with azithromycin and clarithromycin .
16377671	0	telithromycin	104,117	Mrp2	96,100	telithromycin	Mrp2	MESH:C106791	1244	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|nmod|transport	Involvement of the drug transporters p_glycoprotein and multidrug resistance-associated protein Mrp2 in telithromycin transport .
12753725	0	telithromycin	90,103	P-Glycoprotein	39,53	telithromycin	P-Glycoprotein	MESH:C106791	5243	Chemical	Gene	estimation|nmod|START_ENTITY estimation|nmod|END_ENTITY	Experimental estimation of the role of P-Glycoprotein in the pharmacokinetic behaviour of telithromycin , a novel ketolide , in comparison with roxithromycin and other macrolides using the Caco-2 cell model .
16423372	0	telithromycin	49,62	cytochrome_P450	112,127	telithromycin	cytochrome P450	MESH:C106791	25251(Tax:10116)	Chemical	Gene	Effect|amod|START_ENTITY Effect|nmod|END_ENTITY	Effect of a newly developed ketolide antibiotic , telithromycin , on metabolism of theophylline and expression of cytochrome_P450 in rats .
12234873	0	telithromycin	105,118	interleukin-1alpha	27,45	telithromycin	interleukin-1alpha	MESH:C106791	3552	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of secretion of interleukin-1alpha and tumor_necrosis_factor_alpha by the ketolide antibiotic telithromycin .
10997931	0	telmisaltan	163,174	angiotensin_II	136,150	telmisaltan	angiotensin II	null	24179(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	Both cMOAT/MRP2 and another unknown transporter -LRB- s -RRB- are responsible for the biliary excretion of glucuronide conjugate of the nonpeptide angiotensin_II antagonist , telmisaltan .
15215792	0	telmisartan	97,108	ACE	293,296	telmisartan	ACE	MESH:C084178	1636	Chemical	Gene	evaluating|dobj|START_ENTITY trials|acl|evaluating Rationale|dobj|trials Rationale|nmod|Study Study|nmod|Subjects Subjects|compound|END_ENTITY	Rationale , design , and baseline characteristics of 2 large , simple , randomized trials evaluating telmisartan , ramipril , and their combination in high-risk patients : the Ongoing Telmisartan_Alone and in Combination with Ramipril Global Endpoint Trial/Telmisartan Randomized Assessment Study in ACE Intolerant Subjects with Cardiovascular_Disease -LRB- ONTARGET/TRANSCEND -RRB- trials .
22272064	0	telmisartan	33,44	ACE	59,62	telmisartan	ACE	MESH:C084178	1636	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Incidence of adverse events with telmisartan compared with ACE inhibitors : evidence from a pooled analysis of clinical trials .
18633177	0	telmisartan	32,43	Angiotensin_II	164,178	telmisartan	Angiotensin II	MESH:C084178	183	Chemical	Gene	reduction|nmod|START_ENTITY reduction|dep|Investigation Investigation|compound|END_ENTITY	Microalbuminuria reduction with telmisartan in normotensive and hypertensive Japanese patients with type 2 diabetes : a post-hoc analysis of The Incipient to Overt : Angiotensin_II Blocker , Telmisartan , Investigation on Type 2 Diabetic_Nephropathy -LRB- INNOVATION -RRB- study .
19463506	0	telmisartan	45,56	C-reactive_protein	77,95	telmisartan	C-reactive protein	MESH:C084178	1401	Chemical	Gene	versus|dobj|START_ENTITY versus|nmod|END_ENTITY	Comparison of the effects of ramipril versus telmisartan on high-sensitivity C-reactive_protein and endothelial progenitor cells after acute_coronary_syndrome .
24118063	0	telmisartan	10,21	COX-2	63,68	telmisartan	COX-2	MESH:C084178	26198(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|nmod|END_ENTITY	Effect of telmisartan on levels of IL-1 , TNF-a , down-regulated COX-2 , MMP-2 , MMP-9 and RANKL/RANK in an experimental periodontitis model .
17399685	0	telmisartan	53,64	adiponectin	19,30	telmisartan	adiponectin	MESH:C084178	9370	Chemical	Gene	transcription|nmod|START_ENTITY transcription|nsubj|Induction Induction|nmod|gene gene|compound|END_ENTITY	Induction of human adiponectin gene transcription by telmisartan , angiotensin receptor blocker , independently on PPAR-gamma activation .
18803955	0	telmisartan	11,22	adiponectin	26,37	telmisartan	adiponectin	MESH:C084178	9370	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Effects of telmisartan on adiponectin levels and body weight in hypertensive patients with glucose_intolerance .
18989258	0	telmisartan	11,22	adiponectin	39,50	telmisartan	adiponectin	MESH:C084178	9370	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|pressure pressure|compound|END_ENTITY	Effects of telmisartan and ramipril on adiponectin and blood pressure in patients with type 2 diabetes .
19403983	0	telmisartan	11,22	adiponectin	91,102	telmisartan	adiponectin	MESH:C084178	9370	Chemical	Gene	therapy|compound|START_ENTITY Effects|nmod|therapy Effects|dep|level level|compound|END_ENTITY	Effects of telmisartan therapy on metabolic profiles and serum high molecular weight -LRB- HMW -RRB- - adiponectin level in Japanese male hypertensive subjects with abdominal_obesity .
19922882	0	telmisartan	90,101	adiponectin	144,155	telmisartan	adiponectin	MESH:C084178	9370	Chemical	Gene	comparison|nmod|START_ENTITY comparison|nmod|concentrations concentrations|compound|END_ENTITY	Prospective , randomized , single-blind comparison of effects of 6 months of treatment with telmisartan versus enalapril on high-molecular-weight adiponectin concentrations in patients with coronary_artery_disease .
11408526	0	telmisartan	24,35	angiotensin_II	92,106	telmisartan	angiotensin II	MESH:C084178	24179(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	AT1 receptor antagonist telmisartan administered peripherally inhibits central responses to angiotensin_II in conscious rats .
11602814	0	telmisartan	21,32	angiotensin_II	67,81	telmisartan	angiotensin II	MESH:C084178	183	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|challenge challenge|amod|END_ENTITY	Inhibitory effect of telmisartan on the blood pressure response to angiotensin_II challenge .
14689372	0	telmisartan	96,107	angiotensin_II	66,80	telmisartan	angiotensin II	MESH:C084178	183	Chemical	Gene	therapy|compound|START_ENTITY END_ENTITY|nmod|therapy	Haemodynamic and pulse wave responses to intravenous infusions of angiotensin_II during chronic telmisartan therapy in normal volunteers .
21841319	0	telmisartan	136,147	angiotensin_II	110,124	telmisartan	angiotensin II	MESH:C084178	183	Chemical	Gene	effect|nmod|START_ENTITY Correlation|dep|effect Correlation|nmod|homologues homologues|nmod|senescence senescence|acl|induced induced|nmod|END_ENTITY	Correlation of different NADPH oxidase homologues with late endothelial progenitor cell senescence induced by angiotensin_II : effect of telmisartan .
22890047	0	telmisartan	21,32	angiotensin_II	60,74	telmisartan	angiotensin II	MESH:C084178	24179(Tax:10116)	Chemical	Gene	penetration|nmod|START_ENTITY penetration|appos|blocker blocker|compound|END_ENTITY	Brain penetration of telmisartan , a unique centrally acting angiotensin_II type 1 receptor blocker , studied by PET in conscious rhesus_macaques .
25107329	0	telmisartan	45,56	angiotensin_II	84,98	telmisartan	angiotensin II	MESH:C084178	11847(Tax:10090)	Chemical	Gene	memory_dysfunction|nmod|START_ENTITY memory_dysfunction|nmod|reduction reduction|nmod|END_ENTITY	Improvement in spatial memory_dysfunction by telmisartan through reduction of brain angiotensin_II and oxidative stress in experimental uremic mice .
26398389	0	telmisartan	60,71	angiotensin_II	28,42	telmisartan	angiotensin II	MESH:C084178	24179(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|blocker blocker|amod|END_ENTITY	The potential effect of the angiotensin_II receptor blocker telmisartan in regulating OVA-induced airway remodeling in experimental rats .
9125273	0	telmisartan	53,64	angiotensin_II	27,41	telmisartan	angiotensin II	MESH:C084178	24179(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|antagonist antagonist|amod|END_ENTITY	Hypotensive effects of the angiotensin_II antagonist telmisartan in conscious chronically-instrumented transgenic rats .
15226620	0	telmisartan	41,52	angiotensin_II_type-1_receptor	66,96	telmisartan	angiotensin II type-1 receptor	MESH:C084178	185	Chemical	Gene	START_ENTITY|appos|blocker blocker|amod|END_ENTITY	-LSB- Pharmacological and clinical profile of telmisartan , a selective angiotensin_II_type-1_receptor blocker -RSB- .
16154710	0	telmisartan	40,51	angiotensin_II_type_1_receptor	78,108	telmisartan	angiotensin II type 1 receptor	MESH:C084178	185	Chemical	Gene	property|nmod|START_ENTITY Role|nmod|property Role|appos|blocker blocker|amod|END_ENTITY	Role of insulin-sensitizing property of telmisartan , a commercially available angiotensin_II_type_1_receptor blocker in preventing the development of atrial_fibrillation .
17122147	0	telmisartan	74,85	angiotensin_II_type_1_receptor	27,57	telmisartan	angiotensin II type 1 receptor	MESH:C084178	185	Chemical	Gene	blocker|appos|START_ENTITY blocker|amod|END_ENTITY	Neuroprotective effects of angiotensin_II_type_1_receptor -LRB- AT1R -RRB- blocker , telmisartan , via modulating AT1R and AT2R signaling in retinal inflammation .
17664855	0	telmisartan	57,68	angiotensin_II_type_1_receptor	15,45	telmisartan	angiotensin II type 1 receptor	MESH:C084178	185	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|antagonist antagonist|amod|END_ENTITY	Effects of the angiotensin_II_type_1_receptor antagonist telmisartan on monocyte adhesion and activation in patients with essential hypertension .
21130741	0	telmisartan	33,44	angiotensin_II_type_1_receptor	94,124	telmisartan	angiotensin II type 1 receptor	MESH:C084178	185	Chemical	Gene	structure|nmod|START_ENTITY involved|nsubjpass|structure involved|nmod|END_ENTITY	Unique `` delta lock '' structure of telmisartan is involved in its strongest binding affinity to angiotensin_II_type_1_receptor .
24578472	0	telmisartan	118,129	angiotensin_II_type_1_receptor	21,51	telmisartan	angiotensin II type 1 receptor	MESH:C084178	11610(Tax:10090)	Chemical	Gene	peroxisome_proliferator-activated_receptor-y|nmod|START_ENTITY blockade|nmod|peroxisome_proliferator-activated_receptor-y blockade|nmod|END_ENTITY	Combined blockade of angiotensin_II_type_1_receptor and activation of peroxisome_proliferator-activated_receptor-y by telmisartan effectively inhibits vascularization and growth of murine endometriosis-like_lesions .
25194744	0	telmisartan	85,96	apolipoprotein_e	53,69	telmisartan	apolipoprotein e	MESH:C084178	25728(Tax:10116)	Chemical	Gene	expressions|nmod|START_ENTITY expressions|amod|END_ENTITY	Strong reduction of low-density_lipoprotein_receptor / apolipoprotein_e expressions by telmisartan in cerebral cortex and hippocampus of stroke resistant spontaneously hypertensive rats .
21479465	0	telmisartan	104,115	hepatocyte_growth_factor	34,58	telmisartan	hepatocyte growth factor	MESH:C084178	15234(Tax:10090)	Chemical	Gene	concentration|nmod|START_ENTITY concentration|compound|END_ENTITY	Differential response of vascular hepatocyte_growth_factor concentration and lipid accumulation between telmisartan and losartan in ApoE-deficient mice .
17460371	0	telmisartan	11,22	insulin	39,46	telmisartan	insulin	MESH:C084178	3630	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|resistance resistance|compound|END_ENTITY	Effects of telmisartan and losartan on insulin resistance in hypertensive patients with metabolic_syndrome .
20056982	0	telmisartan	29,40	insulin	50,57	telmisartan	insulin	MESH:C084178	3630	Chemical	Gene	improves|nsubj|START_ENTITY improves|dobj|sensitivity sensitivity|compound|END_ENTITY	Angiotensin receptor blocker telmisartan improves insulin sensitivity in peritoneal_dialysis patients .
20388049	0	telmisartan	151,162	insulin	15,22	telmisartan	insulin	MESH:C084178	3630	Chemical	Gene	treatment|compound|START_ENTITY dosage|nmod|treatment diabetes_mellitus|nmod|dosage diabetes_mellitus|nsubj|Alterations Alterations|nmod|resistance resistance|compound|END_ENTITY	Alterations of insulin resistance and the serum adiponectin level in patients with type 2 diabetes_mellitus under the usual antihypertensive dosage of telmisartan treatment .
20467177	0	telmisartan	30,41	insulin	4,11	telmisartan	insulin	MESH:C084178	3630	Chemical	Gene	effect|nmod|START_ENTITY sparing|dobj|effect END_ENTITY|acl|sparing	The insulin sparing effect of telmisartan in a case of type 2 diabetes_mellitus associated with schizophrenia under treatment of risperidone .
20823643	0	telmisartan	11,22	insulin	26,33	telmisartan	insulin	MESH:C084178	3630	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|resistance resistance|compound|END_ENTITY	Effects of telmisartan on insulin resistance in Japanese type 2 diabetic patients .
25151319	0	telmisartan	40,51	insulin	79,86	telmisartan	insulin	MESH:C084178	3630	Chemical	Gene	trials|nmod|START_ENTITY meta-analysis|nmod|trials meta-analysis|nmod|controls controls|nmod|resistance resistance|compound|END_ENTITY	A meta-analysis of randomized trials of telmisartan versus active controls for insulin resistance in hypertensive patients .
19289654	0	telmisartan	78,89	interleukin-6	50,63	telmisartan	interleukin-6	MESH:C084178	24498(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Inhibition of tumor_necrosis_factor-alpha-induced interleukin-6 expression by telmisartan through cross-talk of peroxisome_proliferator-activated_receptor-gamma with nuclear factor kappaB and CCAAT/enhancer-binding protein-beta .
23235712	0	telmisartan	11,22	interleukin-6	34,47	telmisartan	interleukin-6	MESH:C084178	3569	Chemical	Gene	therapy|compound|START_ENTITY therapy|nmod|levels levels|amod|END_ENTITY	Effects of telmisartan therapy on interleukin-6 and tumor_necrosis_factor-alpha levels : a meta-analysis of randomized controlled trials .
21146687	0	telmisartan	23,34	monocyte_chemoattractant_protein-1_and_peroxisome_proliferator-activated_receptor-gamma	53,140	telmisartan	monocyte chemoattractant protein-1 and peroxisome proliferator-activated receptor-gamma	MESH:C084178	6347;5468	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|amod|END_ENTITY	Differential effect of telmisartan and amlodipine on monocyte_chemoattractant_protein-1_and_peroxisome_proliferator-activated_receptor-gamma gene expression in peripheral monocytes in patients with essential hypertension .
15868121	0	telmisartan	33,44	peroxisome_proliferator-activated_receptor-gamma	50,98	telmisartan	peroxisome proliferator-activated receptor-gamma	MESH:C084178	5468	Chemical	Gene	Treating|dobj|START_ENTITY Treating|nmod|activator activator|amod|END_ENTITY	Treating the metabolic_syndrome : telmisartan as a peroxisome_proliferator-activated_receptor-gamma activator .
17691961	0	telmisartan	21,32	peroxisome_proliferator-activated_receptor-gamma	81,129	telmisartan	peroxisome proliferator-activated receptor-gamma	MESH:C084178	5468	Chemical	Gene	START_ENTITY|appos|blocker blocker|nmod|END_ENTITY	Potential utility of telmisartan , an angiotensin II type 1 receptor blocker with peroxisome_proliferator-activated_receptor-gamma -LRB- PPAR-gamma -RRB- - modulating activity for the treatment of cardiometabolic_disorders .
19147680	0	telmisartan	72,83	peroxisome_proliferator-activated_receptor-gamma	12,60	telmisartan	peroxisome proliferator-activated receptor-gamma	MESH:C084178	5468	Chemical	Gene	modulator|appos|START_ENTITY modulator|amod|END_ENTITY	A selective peroxisome_proliferator-activated_receptor-gamma modulator , telmisartan , binds to the receptor in a different fashion from thiazolidinediones .
19289654	0	telmisartan	78,89	peroxisome_proliferator-activated_receptor-gamma	112,160	telmisartan	peroxisome proliferator-activated receptor-gamma	MESH:C084178	25664(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY Inhibition|nmod|expression Inhibition|nmod|END_ENTITY	Inhibition of tumor_necrosis_factor-alpha-induced interleukin-6 expression by telmisartan through cross-talk of peroxisome_proliferator-activated_receptor-gamma with nuclear factor kappaB and CCAAT/enhancer-binding protein-beta .
19635982	0	telmisartan	96,107	peroxisome_proliferator-activated_receptor-gamma	126,174	telmisartan	peroxisome proliferator-activated receptor-gamma	MESH:C084178	19016(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Cognitive_deficit in amyloid-beta-injected mice was improved by pretreatment with a low dose of telmisartan partly because of peroxisome_proliferator-activated_receptor-gamma activation .
20498620	0	telmisartan	12,23	peroxisome_proliferator-activated_receptor-gamma	60,108	telmisartan	peroxisome proliferator-activated receptor-gamma	MESH:C084178	19016(Tax:10090)	Chemical	Gene	dose|nmod|START_ENTITY prevents|nsubj|dose prevents|nmod|activation activation|amod|END_ENTITY	Low dose of telmisartan prevents ischemic brain_damage with peroxisome_proliferator-activated_receptor-gamma activation in diabetic mice .
20595663	0	telmisartan	23,34	peroxisome_proliferator-activated_receptor-gamma	84,132	telmisartan	peroxisome proliferator-activated receptor-gamma	MESH:C084178	19016(Tax:10090)	Chemical	Gene	attenuates|compound|START_ENTITY dose|nmod|attenuates cognitive_impairment|nsubj|dose cognitive_impairment|xcomp|due due|nmod|activation activation|amod|END_ENTITY	Nonhypotensive dose of telmisartan attenuates cognitive_impairment partially due to peroxisome_proliferator-activated_receptor-gamma activation in mice with chronic cerebral_hypoperfusion .
18344629	0	telmisartan	56,67	peroxisome_proliferator-activated_receptor_gamma	76,124	telmisartan	peroxisome proliferator-activated receptor gamma	MESH:C084178	25664(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|property property|amod|END_ENTITY	Inhibition of vascular angiotensin-converting_enzyme by telmisartan via the peroxisome_proliferator-activated_receptor_gamma agonistic property in rats .
24424487	0	telmisartan	23,34	peroxisome_proliferator-activated_receptor_y	63,107	telmisartan	peroxisome proliferator-activated receptor y	MESH:C084178	5468	Chemical	Gene	START_ENTITY|nmod|activities activities|nmod|END_ENTITY	Distinct properties of telmisartan on agonistic activities for peroxisome_proliferator-activated_receptor_y among clinically used angiotensin II receptor blockers : drug-target interaction analyses .
23426788	0	telmisartan	101,112	peroxisome_proliferator_activated_receptor_gamma	16,64	telmisartan	peroxisome proliferator activated receptor gamma	MESH:C084178	19016(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Tissue-specific peroxisome_proliferator_activated_receptor_gamma expression and metabolic effects of telmisartan .
17506942	0	telmisartan	10,21	protein_kinase_C-alpha	39,61	telmisartan	protein kinase C-alpha	MESH:C084178	18750(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of telmisartan on expression of protein_kinase_C-alpha in kidneys of diabetic mice .
2879585	0	temelastine	41,52	histamine_H1-receptor	63,84	temelastine	histamine H1-receptor	MESH:C049054	100135539(Tax:10141)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Pharmacological studies with SK_F_93944 -LRB- temelastine -RRB- , a novel histamine_H1-receptor antagonist with negligible ability to penetrate the central nervous system .
10372231	0	temocapril	41,51	ACE	26,29	temocapril	ACE	MESH:C055603	100009274(Tax:9986)	Chemical	Gene	lowers|advmod|START_ENTITY lowers|nsubj|treatment treatment|nmod|inhibitor inhibitor|compound|END_ENTITY	Chronic treatment with an ACE inhibitor , temocapril , lowers the threshold for the infarct size-limiting effect of ischemic preconditioning .
11131271	0	temocapril	64,74	ACE	49,52	temocapril	ACE	MESH:C055603	1636	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Comparison of long-term therapeutic effect of an ACE inhibitor , temocapril , with that of a diuretic on microalbuminuria in non-diabetic essential hypertension .
11550111	0	temocapril	38,48	ACE	23,26	temocapril	ACE	MESH:C055603	1636	Chemical	Gene	inhibitor|dep|START_ENTITY inhibitor|compound|END_ENTITY	Effects of long-acting ACE inhibitor -LRB- temocapril -RRB- and long-acting Ca channel blocker -LRB- amlodipine -RRB- on 24-h ambulatory BP in elderly hypertensive patients .
8513851	0	temocapril	20,30	ACE	35,38	temocapril	ACE	MESH:C055603	1636	Chemical	Gene	Pharmacokinetics|nmod|START_ENTITY Pharmacokinetics|appos|inhibitor inhibitor|compound|END_ENTITY	Pharmacokinetics of temocapril , an ACE inhibitor with preferential biliary_excretion , in patients with impaired_liver_function .
9661803	0	temocapril	41,51	ACE	26,29	temocapril	ACE	MESH:C055603	1636	Chemical	Gene	reduces|advmod|START_ENTITY reduces|nsubj|therapy therapy|nmod|inhibitor inhibitor|compound|END_ENTITY	Long-term therapy with an ACE inhibitor , temocapril , reduces microalbuminuria in essential hypertension .
23013132	0	temocapril	41,51	Matrix_metalloproteinase-2	0,26	temocapril	Matrix metalloproteinase-2	MESH:C055603	4313	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|END_ENTITY	Matrix_metalloproteinase-2 inhibition by temocapril and its important role in peritoneal transport .
7815741	0	temocapril	15,25	angiotensin-converting_enzyme	30,59	temocapril	angiotensin-converting enzyme	MESH:C055603	24310(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	-LSB- The effect of temocapril , an angiotensin-converting_enzyme inhibitor with preferential biliary excretion , on experimental diabetic_nephropathy -RSB- .
8427943	0	temocapril	98,108	angiotensin_converting_enzyme	57,86	temocapril	angiotensin converting enzyme	MESH:C055603	1636	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Study on pharmacokinetics of a new biliary excreted oral angiotensin_converting_enzyme inhibitor , temocapril -LRB- CS-622 -RRB- in humans .
9715789	0	temocapril	55,65	angiotensin_converting_enzyme	15,44	temocapril	angiotensin converting enzyme	MESH:C055603	1636	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Effects of the angiotensin_converting_enzyme inhibitor temocapril on insulin sensitivity and its effects on renal sodium handling and the pressor system in essential_hypertensive_patients .
25825051	0	temozolomide	53,65	ADAM8	32,37	temozolomide	ADAM8	MESH:C047246	101	Chemical	Gene	contributes|xcomp|START_ENTITY contributes|nsubj|END_ENTITY	The metalloprotease-disintegrin ADAM8 contributes to temozolomide chemoresistance and enhanced invasiveness of human glioblastoma cells .
23338526	0	temozolomide	55,67	AKT	76,79	temozolomide	AKT	MESH:C047246	207	Chemical	Gene	effect|nmod|START_ENTITY enhances|dobj|effect enhances|nmod|END_ENTITY	Downregulation of Src enhances the cytotoxic effect of temozolomide through AKT in glioma .
22156195	0	temozolomide	52,64	Alkylpurine-DNA-N-glycosylase	0,29	temozolomide	Alkylpurine-DNA-N-glycosylase	MESH:C047246	4350	Chemical	Gene	confers|advcl|START_ENTITY confers|nsubj|END_ENTITY	Alkylpurine-DNA-N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients .
26423602	0	temozolomide	63,75	ErbB	26,30	temozolomide	ErbB	MESH:C047246	1956	Chemical	Gene	family|nmod|START_ENTITY family|compound|END_ENTITY	Afatinib , an irreversible ErbB family blocker , with protracted temozolomide in recurrent glioblastoma : a case report .
25061500	0	temozolomide	26,38	HOXA10	0,6	temozolomide	HOXA10	MESH:C047246	3206	Chemical	Gene	resistance|amod|START_ENTITY associated|nmod|resistance associated|nsubjpass|END_ENTITY	HOXA10 is associated with temozolomide resistance through regulation of the homologous recombinant DNA repair pathway in glioblastoma cell lines .
24316756	0	temozolomide	19,31	JNK	0,3	temozolomide	JNK	MESH:C047246	5599	Chemical	Gene	contributes|xcomp|START_ENTITY contributes|nsubj|END_ENTITY	JNK contributes to temozolomide resistance of stem-like glioblastoma cells via regulation of MGMT expression .
16075413	0	temozolomide	117,129	MGMT	160,164	temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	START_ENTITY|dobj|O O|compound|END_ENTITY	The P140K mutant of human O -LRB- 6 -RRB- - methylguanine-DNA-methyltransferase -LRB- MGMT -RRB- confers resistance in vitro and in vivo to temozolomide in combination with the novel MGMT inactivator O -LRB- 6 -RRB- - -LRB- 4-bromothenyl -RRB- guanine .
16075413	0	temozolomide	117,129	MGMT	68,72	temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	confers|advcl|START_ENTITY methylguanine-DNA-methyltransferase|acl:relcl|confers methylguanine-DNA-methyltransferase|appos|END_ENTITY	The P140K mutant of human O -LRB- 6 -RRB- - methylguanine-DNA-methyltransferase -LRB- MGMT -RRB- confers resistance in vitro and in vivo to temozolomide in combination with the novel MGMT inactivator O -LRB- 6 -RRB- - -LRB- 4-bromothenyl -RRB- guanine .
16609952	0	temozolomide	78,90	MGMT	0,4	temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	correlates|xcomp|START_ENTITY correlates|nsubj|methylation methylation|amod|END_ENTITY	MGMT promoter methylation correlates with survival benefit and sensitivity to temozolomide in pediatric glioblastoma .
17192931	0	temozolomide	42,54	MGMT	0,4	temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	marker|acl|START_ENTITY methylation|dep|marker methylation|amod|END_ENTITY	MGMT methylation : a marker of response to temozolomide in low-grade gliomas .
17721049	0	temozolomide	12,24	MGMT	109,113	temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	Efficacy|nmod|START_ENTITY correlated|nsubjpass|Efficacy correlated|nmod|loss loss|nmod|END_ENTITY	Efficacy of temozolomide is correlated with 1p loss and methylation of the deoxyribonucleic acid repair gene MGMT in malignant_gliomas .
17967314	0	temozolomide	43,55	MGMT	59,63	temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	START_ENTITY|nmod|promoter promoter|amod|END_ENTITY	Differential radiosensitizing potential of temozolomide in MGMT promoter methylated glioblastoma multiforme cell lines .
18647495	0	temozolomide	36,48	MGMT	56,60	temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	START_ENTITY|nmod|glioblastomas glioblastomas|compound|END_ENTITY	Impact of p53 status to response of temozolomide in low MGMT expression glioblastomas : preliminary results .
18945611	0	temozolomide	71,83	MGMT	0,4	temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	correlates|nmod|START_ENTITY correlates|nsubj|hypermethylation hypermethylation|amod|END_ENTITY	MGMT promoter hypermethylation correlates with a survival benefit from temozolomide in patients with recurrent anaplastic_astrocytoma but not glioblastoma .
18952979	0	temozolomide	48,60	MGMT	13,17	temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	resistance|amod|START_ENTITY associated|nmod|resistance associated|nsubjpass|Induction Induction|nmod|expression expression|amod|END_ENTITY	Induction of MGMT expression is associated with temozolomide resistance in glioblastoma xenografts .
19011762	0	temozolomide	68,80	MGMT	14,18	temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	response|amod|START_ENTITY methylation|nmod|response methylation|nsubj|Evaluation Evaluation|nmod|promoter promoter|amod|END_ENTITY	Evaluation of MGMT promoter methylation status and correlation with temozolomide response in orthotopic_glioblastoma xenograft model .
19067722	0	temozolomide	77,89	MGMT	44,48	temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	expression|acl|START_ENTITY O6-methylguanine-DNA_methyltransferase|dobj|expression O6-methylguanine-DNA_methyltransferase|dep|END_ENTITY	Low O6-methylguanine-DNA_methyltransferase -LRB- MGMT -RRB- expression and response to temozolomide in aggressive pituitary_tumours .
19536096	0	temozolomide	83,95	MGMT	10,14	temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	given|xcomp|START_ENTITY glioblastomas|acl|given outcome|nmod|glioblastomas correlates|nmod|outcome correlates|nsubj|Extent Extent|nmod|methylation methylation|amod|END_ENTITY	Extent of MGMT promoter methylation correlates with outcome in glioblastomas given temozolomide and radiotherapy .
19703338	0	temozolomide	120,132	MGMT	46,50	temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	START_ENTITY|nsubj|value value|nmod|p53 p53|nmod|END_ENTITY	Prognostic and predictive value of p53 in low MGMT expressing glioblastoma treated with surgery , radiation and adjuvant temozolomide chemotherapy .
20032445	0	temozolomide	25,37	MGMT	72,76	temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	therapy|nmod|START_ENTITY END_ENTITY|nsubj|therapy	Anti-glioma therapy with temozolomide and status of the DNA-repair gene MGMT .
20457618	0	temozolomide	29,41	MGMT	111,115	temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	doses|nmod|START_ENTITY produce|nsubj|doses produce|dobj|radiosensitization radiosensitization|nmod|cells cells|advmod|regardless regardless|nmod|expression expression|amod|END_ENTITY	Minimally cytotoxic doses of temozolomide produce radiosensitization in human glioblastoma cells regardless of MGMT expression .
20517307	0	temozolomide	100,112	MGMT	15,19	temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	sensitivity|nmod|START_ENTITY predict|dobj|sensitivity predict|nsubj|Absence Absence|nmod|protein protein|amod|END_ENTITY	Absence of the MGMT protein as well as methylation of the MGMT promoter predict the sensitivity for temozolomide .
20525765	0	temozolomide	89,101	MGMT	36,40	temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	enhances|advcl|START_ENTITY enhances|dobj|inhibition inhibition|amod|END_ENTITY	Levetiracetam enhances p53-mediated MGMT inhibition and sensitizes glioblastoma cells to temozolomide .
20736948	0	temozolomide	60,72	MGMT	0,4	temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	treatment|amod|START_ENTITY tolerance|nmod|treatment correlates|nmod|tolerance correlates|nsubj|methylation methylation|compound|END_ENTITY	MGMT gene promoter methylation correlates with tolerance of temozolomide treatment in melanoma but not with clinical outcome .
20861061	0	temozolomide	97,109	MGMT	25,29	temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	methylation|nmod|START_ENTITY methylation|nsubj|influence influence|nmod|END_ENTITY	Predominant influence of MGMT methylation in non-resectable glioblastoma after radiotherapy plus temozolomide .
21329652	0	temozolomide	29,41	MGMT	93,97	temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	resistance|amod|START_ENTITY resistance|dep|Inactivation Inactivation|nmod|END_ENTITY	A novel approach to overcome temozolomide resistance in glioma and melanoma : Inactivation of MGMT by gene therapy .
21418965	0	temozolomide	46,58	MGMT	15,19	temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	expression|nmod|START_ENTITY expression|nsubj|Comparison Comparison|nmod|END_ENTITY	-LSB- Comparison of MGMT and ERCC expression in temozolomide for the treatment of malignant_glioma drug resistance and their genetic relationship -RSB- .
22052619	0	temozolomide	9,21	MGMT	43,47	temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	START_ENTITY|nmod|status status|amod|END_ENTITY	Tailored temozolomide therapy according to MGMT methylation status for elderly patients with acute_myeloid_leukemia .
22052619	2	temozolomide	268,280	MGMT	305,309	temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	dose|amod|START_ENTITY tailored|nsubjpass|dose tailored|nmod|status status|amod|END_ENTITY	This study assessed whether the temozolomide dose can be tailored by MGMT promoter status and whether protracted , low-dose temozolomide can `` prime '' blasts in patients with unmethylated MGMT -LRB- unMGMT -RRB- .
22426504	0	temozolomide	21,33	MGMT	66,70	temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	resistance|amod|START_ENTITY reverses|dobj|resistance reverses|nmod|downregulation downregulation|nmod|END_ENTITY	Resveratrol reverses temozolomide resistance by downregulation of MGMT in T98G glioblastoma cells by the NF-kB-dependent pathway .
22532597	0	temozolomide	27,39	MGMT	85,89	temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	resistance|amod|START_ENTITY overcomes|dobj|resistance overcomes|advcl|downregulating downregulating|dobj|expression expression|amod|END_ENTITY	STAT3 inhibition overcomes temozolomide resistance in glioblastoma by downregulating MGMT expression .
22614944	0	temozolomide	110,122	MGMT	24,28	temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	bevacizumab|compound|START_ENTITY receiving|dobj|bevacizumab patients|acl|receiving status|nmod|patients status|amod|END_ENTITY	Predictive value of the MGMT promoter methylation status in metastatic_melanoma patients receiving first-line temozolomide plus bevacizumab in the trial SAKK 50/07 .
22675172	0	temozolomide	74,86	MGMT	108,112	temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	resistance|amod|START_ENTITY resistance|acl|linked linked|xcomp|END_ENTITY	Inhibition of histone deacetylation potentiates the evolution of acquired temozolomide resistance linked to MGMT upregulation in glioblastoma xenografts .
22788764	0	temozolomide	50,62	MGMT	97,101	temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	using|dobj|START_ENTITY improve|xcomp|using Strategies|acl|improve END_ENTITY|nsubj|Strategies	Strategies to improve the killing of tumors using temozolomide : targeting the DNA repair protein MGMT .
23042021	0	temozolomide	12,24	MGMT	121,125	temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	Efficacy|nmod|START_ENTITY Efficacy|dep|methyltransferase methyltransferase|appos|END_ENTITY	Efficacy of temozolomide in a central nervous system relapse of neuroblastoma with O 6 - methylguanine methyltransferase -LRB- MGMT -RRB- promoter methylation .
23047291	0	temozolomide	38,50	MGMT	137,141	temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	response|amod|START_ENTITY analysis|nmod|response shows|nsubj|analysis shows|dobj|association association|nmod|END_ENTITY	A genome-wide association analysis of temozolomide response using lymphoblastoid cell lines shows a clinically relevant association with MGMT .
23245659	0	temozolomide	143,155	MGMT	0,4	temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|status status|compound|END_ENTITY	MGMT promoter methylation status and MGMT and CD133 immunohistochemical expression as prognostic markers in glioblastoma patients treated with temozolomide plus radiotherapy .
23479134	0	temozolomide	23,35	MGMT	57,61	temozolomide	MGMT	MESH:C047246	17314(Tax:10090)	Chemical	Gene	dosing|compound|START_ENTITY Efficacy|nmod|dosing limited|nsubjpass|Efficacy limited|nmod|models models|amod|END_ENTITY	Efficacy of protracted temozolomide dosing is limited in MGMT unmethylated GBM xenograft models .
23561593	0	temozolomide	58,70	MGMT	0,4	temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	cells|nmod|START_ENTITY treatment|nmod|cells repletion|nmod|treatment repletion|amod|END_ENTITY	MGMT repletion after treatment of glioblastoma cells with temozolomide and O6-benzylguanine implicates NFkB and mutant p53 .
23686298	0	temozolomide	99,111	MGMT	40,44	temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	immunohistochemistry|xcomp|START_ENTITY immunohistochemistry|nsubj|O6-methylguanine-DNA_methyltransferase O6-methylguanine-DNA_methyltransferase|appos|END_ENTITY	O6-methylguanine-DNA_methyltransferase -LRB- MGMT -RRB- immunohistochemistry as a predictor of resistance to temozolomide in primary CNS_lymphoma .
23958055	0	temozolomide	40,52	MGMT	9,13	temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	contributes|xcomp|START_ENTITY contributes|nsubj|expression expression|compound|END_ENTITY	Enhanced MGMT expression contributes to temozolomide resistance in glioma stem-like cells .
23970362	0	temozolomide	56,68	MGMT	83,87	temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	START_ENTITY|advcl|regulating regulating|dobj|expression expression|amod|END_ENTITY	HIF-1a inhibition sensitizes pituitary_adenoma cells to temozolomide by regulating MGMT expression .
24316756	0	temozolomide	19,31	MGMT	93,97	temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	START_ENTITY|dobj|resistance resistance|nmod|cells cells|nmod|regulation regulation|nmod|expression expression|amod|END_ENTITY	JNK contributes to temozolomide resistance of stem-like glioblastoma cells via regulation of MGMT expression .
24519517	0	temozolomide	65,77	MGMT	0,4	temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	receiving|dobj|START_ENTITY methylation|acl|receiving methylation|amod|END_ENTITY	MGMT promoter methylation in plasma of glioma patients receiving temozolomide .
24568970	0	temozolomide	83,95	MGMT	48,52	temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	cytosine|xcomp|START_ENTITY cytosine|dobj|modifications modifications|nmod|expression expression|amod|END_ENTITY	The role of gene body cytosine modifications in MGMT expression and sensitivity to temozolomide .
25078279	0	temozolomide	101,113	MGMT	142,146	temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	START_ENTITY|nmod|methylation methylation|amod|END_ENTITY	Novel MSH6 mutations in treatment-na ve glioblastoma and anaplastic_oligodendroglioma contribute to temozolomide resistance independently of MGMT promoter methylation .
25233099	0	temozolomide	134,146	MGMT	58,62	temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	radio-chemotherapy|nmod|START_ENTITY treated|nmod|radio-chemotherapy patients|acl|treated modulates|nmod|patients modulates|dobj|value value|nmod|END_ENTITY	DGKI methylation status modulates the prognostic value of MGMT in glioblastoma patients treated with combined radio-chemotherapy with temozolomide .
25779137	0	temozolomide	38,50	MGMT	66,70	temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	independent|amod|START_ENTITY independent|nmod|status status|amod|END_ENTITY	ABT-888 enhances cytotoxic effects of temozolomide independent of MGMT status in serum free cultured glioma cells .
25886061	0	temozolomide	38,50	MGMT	66,70	temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	independent|amod|START_ENTITY independent|nmod|status status|amod|END_ENTITY	ABT-888 enhances cytotoxic effects of temozolomide independent of MGMT status in serum free cultured glioma cells .
25910840	0	temozolomide	120,132	MGMT	4,8	temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	factor|xcomp|START_ENTITY factor|nsubj|rs16906252 rs16906252|compound|END_ENTITY	The MGMT promoter SNP rs16906252 is a risk factor for MGMT methylation in glioblastoma and is predictive of response to temozolomide .
25910840	0	temozolomide	120,132	MGMT	54,58	temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	factor|xcomp|START_ENTITY factor|nmod|methylation methylation|amod|END_ENTITY	The MGMT promoter SNP rs16906252 is a risk factor for MGMT methylation in glioblastoma and is predictive of response to temozolomide .
26518768	0	temozolomide	52,64	MGMT	0,4	temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	era|amod|START_ENTITY therapy|nmod|era allows|nmod|therapy allows|nsubj|testing testing|amod|END_ENTITY	MGMT testing allows for personalised therapy in the temozolomide era .
26648123	0	temozolomide	42,54	MGMT	119,123	temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Sulforaphane reverses chemo-resistance to temozolomide in glioblastoma cells by NF-kB-dependent pathway downregulating MGMT expression .
26916096	0	temozolomide	61,73	MGMT	6,10	temozolomide	MGMT	MESH:C047246	4255	Chemical	Gene	START_ENTITY|nsubj|changes changes|compound|END_ENTITY	Tumor MGMT promoter hypermethylation changes over time limit temozolomide efficacy in a phase II trial for metastatic colorectal_cancer .
26951384	0	temozolomide	70,82	MGMT	109,113	temozolomide	MGMT	MESH:C047246	17314(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|downregulation downregulation|nmod|END_ENTITY	Endoplasmic reticulum stress-inducing drugs sensitize glioma cells to temozolomide through downregulation of MGMT , MPG , and Rad51 .
20150365	0	temozolomide	93,105	O6-Methylguanine_DNA_methyltransferase	0,38	temozolomide	O6-Methylguanine DNA methyltransferase	MESH:C047246	4255	Chemical	Gene	therapy|amod|START_ENTITY outcome|nmod|therapy predicts|dobj|outcome predicts|nsubj|expression expression|amod|END_ENTITY	O6-Methylguanine_DNA_methyltransferase protein expression in tumor cells predicts outcome of temozolomide therapy in glioblastoma patients .
8624262	0	temozolomide	122,134	O6-alkylguanine-DNA_alkyltransferase	73,109	temozolomide	O6-alkylguanine-DNA alkyltransferase	MESH:C047246	17314(Tax:10090)	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	O6-benzylguanine enhances the sensitivity of a glioma xenograft with low O6-alkylguanine-DNA_alkyltransferase activity to temozolomide and BCNU .
16405512	0	temozolomide	62,74	O6-methylguanine_DNA_methyltransferase	0,38	temozolomide	O6-methylguanine DNA methyltransferase	MESH:C047246	4255	Chemical	Gene	sensitivity|amod|START_ENTITY predict|dobj|sensitivity predict|nsubj|status status|compound|END_ENTITY	O6-methylguanine_DNA_methyltransferase and p53 status predict temozolomide sensitivity in human malignant_glioma cells .
16954518	0	temozolomide	127,139	O6-methylguanine_DNA_methyltransferase	21,59	temozolomide	O6-methylguanine DNA methyltransferase	MESH:C047246	4255	Chemical	Gene	methylation|advcl|START_ENTITY methylation|nsubj|Correlations Correlations|nmod|promoter promoter|compound|END_ENTITY	Correlations between O6-methylguanine_DNA_methyltransferase promoter methylation status , 1p and 19q deletions , and response to temozolomide in anaplastic and recurrent oligodendroglioma : a prospective GICNO study .
19056675	0	temozolomide	63,75	O6-methylguanine_DNA_methyltransferase	90,128	temozolomide	O6-methylguanine DNA methyltransferase	MESH:C047246	4255	Chemical	Gene	activity|nmod|START_ENTITY sensitizes|nmod|activity sensitizes|advcl|modulating modulating|dobj|expression expression|compound|END_ENTITY	IFN-beta sensitizes neuroblastoma to the antitumor activity of temozolomide by modulating O6-methylguanine_DNA_methyltransferase expression .
23715499	0	temozolomide	78,90	O6-methylguanine_DNA_methyltransferase	104,142	temozolomide	O6-methylguanine DNA methyltransferase	MESH:C047246	4255	Chemical	Gene	START_ENTITY|advcl|affecting affecting|dobj|methylation methylation|compound|END_ENTITY	Glycogen_synthase_kinase_3b inhibition sensitizes human glioblastoma cells to temozolomide by affecting O6-methylguanine_DNA_methyltransferase promoter methylation via c-Myc signaling .
25111384	0	temozolomide	60,72	O6-methylguanine_DNA_methyltransferase	120,158	temozolomide	O6-methylguanine DNA methyltransferase	MESH:C047246	4255	Chemical	Gene	combined|nmod|START_ENTITY combined|nmod|cell cell|acl|expressing expressing|dobj|END_ENTITY	Enhanced anti-tumor effect of zoledronic_acid combined with temozolomide against human malignant_glioma cell expressing O6-methylguanine_DNA_methyltransferase .
19035287	0	temozolomide	40,52	PARP	100,104	temozolomide	PARP	MESH:C047246	142	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|dep|correlation correlation|nmod|levels levels|nmod|activity activity|compound|END_ENTITY	The PARP inhibitor , ABT-888 potentiates temozolomide : correlation with drug levels and reduction in PARP activity in vivo .
19035287	0	temozolomide	40,52	PARP	4,8	temozolomide	PARP	MESH:C047246	142	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	The PARP inhibitor , ABT-888 potentiates temozolomide : correlation with drug levels and reduction in PARP activity in vivo .
20464779	0	temozolomide	136,148	PARP	59,63	temozolomide	PARP	MESH:C047246	11545(Tax:10090)	Chemical	Gene	increases|nmod|START_ENTITY increases|nsubj|inhibition inhibition|nmod|activity activity|appos|END_ENTITY	Pharmacological inhibition of poly -LRB- ADP-ribose -RRB- _ polymerase -LRB- PARP -RRB- activity in PARP-1 silenced tumour cells increases chemosensitivity to temozolomide and to a N3-adenine selective methylating agent .
23423489	0	temozolomide	87,99	PARP	31,35	temozolomide	PARP	MESH:C047246	142	Chemical	Gene	study|nmod|START_ENTITY study|nmod|inhibitor inhibitor|compound|END_ENTITY	A phase II study of the potent PARP inhibitor , Rucaparib -LRB- PF-01367338 , AG014699 -RRB- , with temozolomide in patients with metastatic_melanoma demonstrating evidence of chemopotentiation .
25500058	0	temozolomide	70,82	PARP	24,28	temozolomide	PARP	MESH:C047246	142	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|activity activity|nmod|END_ENTITY	Synergistic activity of PARP inhibition by talazoparib -LRB- BMN 673 -RRB- with temozolomide in pediatric_cancer models in the pediatric preclinical testing program .
22102081	0	temozolomide	148,160	TOP2A	166,171	temozolomide	TOP2A	MESH:C047246	7153	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|compound|END_ENTITY	Higher topoisomerase 2 alpha gene transcript levels predict better prognosis in GBM patients receiving temozolomide chemotherapy : identification of temozolomide as a TOP2A inhibitor .
23554660	0	temozolomide	68,80	U87	84,87	temozolomide	U87	MESH:C047246	641648	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	MiR-181b suppresses proliferation of and reduces chemoresistance to temozolomide in U87 glioma stem cells .
25779144	0	temozolomide	33,45	miR-130a	0,8	temozolomide	miR-130a	MESH:C047246	406919	Chemical	Gene	predict|advcl|START_ENTITY predict|nsubj|END_ENTITY	miR-130a can predict response to temozolomide in patients with glioblastoma_multiforme , independently of O6-methylguanine-DNA_methyltransferase .
17638900	0	temozolomide	48,60	nuclear_factor-kappaB	14,35	temozolomide	nuclear factor-kappaB	MESH:C047246	4790	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Inhibition of nuclear_factor-kappaB activity by temozolomide involves O6-methylguanine induced inhibition of p65 DNA binding .
19703338	0	temozolomide	120,132	p53	35,38	temozolomide	p53	MESH:C047246	7157	Chemical	Gene	START_ENTITY|nsubj|value value|nmod|END_ENTITY	Prognostic and predictive value of p53 in low MGMT expressing glioblastoma treated with surgery , radiation and adjuvant temozolomide chemotherapy .
26428461	0	temozolomide	94,106	p53	125,128	temozolomide	p53	MESH:C047246	7157	Chemical	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	A stapled peptide antagonist of MDM2 carried by polymeric micelles sensitizes glioblastoma to temozolomide treatment through p53 activation .
21351275	0	temsirolimus	152,164	BRAF	0,4	temsirolimus	BRAF	MESH:C401859	109880(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|inhibition inhibition|amod|END_ENTITY	BRAF mutation-selective inhibition of thyroid_cancer cells by the novel MEK inhibitor RDEA119 and genetic-potentiated synergism with the mTOR inhibitor temsirolimus .
22722792	0	temsirolimus	88,100	MTOR	72,76	temsirolimus	MTOR	MESH:C401859	2475	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Brief report : a phase II `` window-of-opportunity '' frontline study of the MTOR inhibitor , temsirolimus given as a single agent in patients with advanced NSCLC , an NCCTG study .
16740688	0	temsirolimus	72,84	Mammalian_target_of_rapamycin	32,61	temsirolimus	Mammalian target of rapamycin	MESH:C401859	2475	Chemical	Gene	START_ENTITY|nsubj|potential potential|nmod|inhibitor inhibitor|compound|END_ENTITY	Antiangiogenic potential of the Mammalian_target_of_rapamycin inhibitor temsirolimus .
15955899	0	temsirolimus	18,30	mTOR	63,67	temsirolimus	mTOR	MESH:C401859	21977(Tax:10090)	Chemical	Gene	study|nmod|START_ENTITY study|appos|inhibitor inhibitor|nmod|END_ENTITY	Phase II study of temsirolimus -LRB- CCI-779 -RRB- , a novel inhibitor of mTOR , in heavily pretreated patients with locally advanced or metastatic breast_cancer .
17145584	0	temsirolimus	40,52	mTOR	55,59	temsirolimus	mTOR	MESH:C401859	21977(Tax:10090)	Chemical	Gene	CCI779|appos|START_ENTITY CCI779|appos|inhibitor inhibitor|compound|END_ENTITY	-LSB- Update on clinical activity of CCI779 -LRB- temsirolimus -RRB- , mTOR inhibitor -RSB- .
20215136	0	temsirolimus	34,46	mTOR	19,23	temsirolimus	mTOR	MESH:C401859	21977(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Treatment Treatment|nmod|inhibitor inhibitor|compound|END_ENTITY	Treatment with the mTOR inhibitor temsirolimus in patients with malignant PEComa .
20418203	0	temsirolimus	18,30	mTOR	1,5	temsirolimus	mTOR	MESH:C401859	21977(Tax:10090)	Chemical	Gene	inhibitors|dep|START_ENTITY inhibitors|compound|END_ENTITY	-LSB- mTOR inhibitors : temsirolimus and everolimus in the treatment of renal_cell_carcinoma -RSB- .
21512806	0	temsirolimus	41,53	mTOR	11,15	temsirolimus	mTOR	MESH:C401859	21977(Tax:10090)	Chemical	Gene	treatment|nmod|START_ENTITY treatment|compound|END_ENTITY	Sequential mTOR inhibitor treatment with temsirolimus in metastatic_renal_cell_carcinoma following failure of VEGF receptor tyrosine kinase inhibitors .
22465830	0	temsirolimus	94,106	mTOR	79,83	temsirolimus	mTOR	MESH:C401859	21977(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|cixutumumab cixutumumab|nmod|inhibitor inhibitor|compound|END_ENTITY	Insulin growth factor-receptor -LRB- IGF-1R -RRB- antibody cixutumumab combined with the mTOR inhibitor temsirolimus in patients with refractory Ewing 's _ sarcoma family tumors .
23271044	0	temsirolimus	17,29	mTOR	45,49	temsirolimus	mTOR	MESH:C401859	21977(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	A combination of temsirolimus , an allosteric mTOR inhibitor , with clofarabine as a new therapeutic option for patients with acute_myeloid_leukemia .
23412108	0	temsirolimus	94,106	mTOR	79,83	temsirolimus	mTOR	MESH:C401859	21977(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|receptor receptor|acl|combined combined|nmod|inhibitor inhibitor|compound|END_ENTITY	Insulin growth factor receptor -LRB- IGF-1R -RRB- antibody cixutumumab combined with the mTOR inhibitor temsirolimus in patients with metastatic adrenocortical_carcinoma .
23537100	0	temsirolimus	34,46	mTOR	10,14	temsirolimus	mTOR	MESH:C401859	21977(Tax:10090)	Chemical	Gene	CCI-779|appos|START_ENTITY CCI-779|compound|END_ENTITY	The novel mTOR inhibitor CCI-779 -LRB- temsirolimus -RRB- induces antiproliferative effects through inhibition of mTOR in Bel-7402 liver_cancer cells .
23537100	0	temsirolimus	34,46	mTOR	104,108	temsirolimus	mTOR	MESH:C401859	21977(Tax:10090)	Chemical	Gene	CCI-779|appos|START_ENTITY induces|nsubj|CCI-779 induces|nmod|inhibition inhibition|nmod|END_ENTITY	The novel mTOR inhibitor CCI-779 -LRB- temsirolimus -RRB- induces antiproliferative effects through inhibition of mTOR in Bel-7402 liver_cancer cells .
23977448	0	temsirolimus	46,58	mTOR	30,34	temsirolimus	mTOR	MESH:C401859	21977(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Preclinical evaluation of the mTOR inhibitor , temsirolimus , in combination with the epothilone_B analog , ixabepilone_in_renal_cell_carcinoma .
24028709	0	temsirolimus	55,67	mTOR	39,43	temsirolimus	mTOR	MESH:C401859	21977(Tax:10090)	Chemical	Gene	toxicities|dep|START_ENTITY toxicities|acl|associated associated|nmod|inhibitors inhibitors|compound|END_ENTITY	Hematologic toxicities associated with mTOR inhibitors temsirolimus and everolimus in cancer patients : a systematic review and meta-analysis .
24378576	0	temsirolimus	68,80	mTOR	53,57	temsirolimus	mTOR	MESH:C401859	21977(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|inhibitor inhibitor|compound|END_ENTITY	Antitumor effect and antiangiogenic potential of the mTOR inhibitor temsirolimus against malignant_pleural_mesothelioma .
24862756	0	temsirolimus	33,45	mTOR	18,22	temsirolimus	mTOR	MESH:C401859	21977(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Resistance Resistance|nmod|inhibitor inhibitor|compound|END_ENTITY	Resistance to the mTOR inhibitor temsirolimus alters adhesion and migration behavior of renal_cell_carcinoma cells through an integrin a5 - and integrin b3-dependent mechanism .
25740597	0	temsirolimus	21,33	mTOR	0,4	temsirolimus	mTOR	MESH:C401859	21977(Tax:10090)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	mTOR inhibition with temsirolimus causes acute increases in glomerular permeability , but inhibits the dynamic permeability actions of puromycin_aminonucleoside .
25887043	0	temsirolimus	49,61	mTOR	33,37	temsirolimus	mTOR	MESH:C401859	21977(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Radio-sensitization effect of an mTOR inhibitor , temsirolimus , on lung_adenocarcinoma A549 cells under normoxic and hypoxic conditions .
21835932	0	temsirolimus	120,132	mammalian_target_of_rapamycin	79,108	temsirolimus	mammalian target of rapamycin	MESH:C401859	2475	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Multimodal biomarker investigation on efficacy and mechanism of action for the mammalian_target_of_rapamycin inhibitor , temsirolimus , in a preclinical mammary_carcinoma OncoMouse model : a translational medicine study in support for early clinical development .
22320865	0	temsirolimus	66,78	mammalian_target_of_rapamycin	14,43	temsirolimus	mammalian target of rapamycin	MESH:C401859	2475	Chemical	Gene	CCI-779|appos|START_ENTITY signaling|nmod|CCI-779 END_ENTITY|acl|signaling	Inhibition of mammalian_target_of_rapamycin signaling by CCI-779 -LRB- temsirolimus -RRB- induces growth inhibition and cell cycle arrest in Cashmere goat fetal fibroblasts -LRB- Capra_hircus -RRB- .
22614575	0	temsirolimus	23,35	mammalian_target_of_rapamycin	39,68	temsirolimus	mammalian target of rapamycin	MESH:C401859	2475	Chemical	Gene	induced|nmod|START_ENTITY inhibitor|advcl|induced inhibitor|nsubj|END_ENTITY	Onychopathy induced by temsirolimus , a mammalian_target_of_rapamycin inhibitor .
1385427	0	tenascin	25,33	Angiotensin_II	0,14	tenascin	Angiotensin II	null	183	Chemical	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Angiotensin_II regulates tenascin gene expression in vascular smooth muscle cells .
1708391	0	tenascin	47,55	Syndecan	0,8	tenascin	Syndecan	null	6382	Chemical	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Syndecan from embryonic tooth mesenchyme binds tenascin .
7504635	0	tenascin	25,33	basic_fibroblast_growth_factor	37,67	tenascin	basic fibroblast growth factor	null	54250(Tax:10116)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of astrocytic tenascin by basic_fibroblast_growth_factor .
1384510	0	tenascin	20,28	interleukin-1	64,77	tenascin	interleukin-1	null	3552	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of human tenascin in synovitis and its regulation by interleukin-1 .
24014134	0	teneligliptin	23,36	DPP-4	46,51	teneligliptin	DPP-4	MESH:C579035	1803	Chemical	Gene	Safety|nmod|START_ENTITY Safety|dep|inhibitor inhibitor|compound|END_ENTITY	Safety and efficacy of teneligliptin : a novel DPP-4 inhibitor for hemodialysis patients with type 2 diabetes .
23022337	0	teneligliptin	68,81	dipeptidyl_peptidase-4	34,56	teneligliptin	dipeptidyl peptidase-4	MESH:C579035	25253(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	A novel , potent , and long-lasting dipeptidyl_peptidase-4 inhibitor , teneligliptin , improves postprandial hyperglycemia and dyslipidemia after single and repeated administrations .
23464664	0	teneligliptin	51,64	dipeptidyl_peptidase-4	68,90	teneligliptin	dipeptidyl peptidase-4	MESH:C579035	1803	Chemical	Gene	relationship|nmod|START_ENTITY Efficacy|appos|relationship Efficacy|appos|inhibitor inhibitor|amod|END_ENTITY	Efficacy , safety and dose-response relationship of teneligliptin , a dipeptidyl_peptidase-4 inhibitor , in Japanese patients with type_2_diabetes_mellitus .
26749529	0	teneligliptin	23,36	dipeptidyl_peptidase-4	46,68	teneligliptin	dipeptidyl peptidase-4	MESH:C579035	1803	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Efficacy and safety of teneligliptin , a novel dipeptidyl_peptidase-4 inhibitor , in Korean patients with type_2_diabetes_mellitus : A 24-week multicenter , randomized , double-blind , placebo-controlled phase III trial .
26749565	0	teneligliptin	23,36	dipeptidyl_peptidase-4	90,112	teneligliptin	dipeptidyl peptidase-4	MESH:C579035	25253(Tax:10116)	Chemical	Gene	distribution|nmod|START_ENTITY reported|nsubj|distribution reported|nmod|inhibitors inhibitors|amod|END_ENTITY	Tissue distribution of teneligliptin in rats and comparisons with data reported for other dipeptidyl_peptidase-4 inhibitors .
1578365	0	teniposide	36,46	cytochrome_P450	6,21	teniposide	cytochrome P450	MESH:D013713	4051	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|amod|END_ENTITY	Human cytochrome_P450 metabolism of teniposide and etoposide .
7514580	0	tenoxicam	10,19	substance_P	66,77	tenoxicam	substance P	MESH:C032801	6863	Chemical	Gene	Effect|nmod|START_ENTITY induced|nsubj|Effect induced|nmod|END_ENTITY	Effect of tenoxicam and indomethacin on the chemotaxis induced by substance_P and interleukin-8 on human monocytes and polymorphonuclear cells .
7255527	1	tensides	78,86	Part_5	55,61	tensides	Part 5	MESH:D013501	8658	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|dep|effects	Part_5 : The effects of tensides on the liberation of atropine from eye ointments -LRB- author 's transl -RRB- -RSB- .
9024987	0	tepoxalin	26,35	NF-kappa_B	4,14	tepoxalin	NF-kappa B	MESH:C073135	4790	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	The NF-kappa_B inhibitor , tepoxalin , suppresses surface expression of the cell adhesion molecules CD62E , CD11b/CD18 and CD106 .
7759567	0	tepoxalin	81,90	NF_kappa_B	15,25	tepoxalin	NF kappa B	MESH:C073135	4790	Chemical	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Suppression of NF_kappa_B activation and NF_kappa_B-dependent gene expression by tepoxalin , a dual inhibitor of cyclooxygenase_and_5-lipoxygenase .
16008217	0	tepoxalin	19,28	cyclooxygenase	46,60	tepoxalin	cyclooxygenase	MESH:C073135	403544(Tax:9615)	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nmod|effects	In vivo effects of tepoxalin , an inhibitor of cyclooxygenase and lipoxygenase , on prostanoid and leukotriene production in dogs with chronic_osteoarthritis .
10471086	0	tepoxalin	41,50	interleukin-6	60,73	tepoxalin	interleukin-6	MESH:C073135	3569	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|synthesis synthesis|amod|END_ENTITY	The non-steroidal anti-inflammatory drug tepoxalin inhibits interleukin-6 and alpha1-anti-chymotrypsin synthesis in astrocytes by preventing degradation of IkappaB-alpha .
3038400	0	teprotide	88,97	renin	27,32	teprotide	renin	MESH:D013722	102122446	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Hypotensive effects of the renin inhibitor -LRB- RI-78 -RRB- and the converting enzyme inhibitor -LRB- teprotide -RRB- in conscious monkeys .
17351661	0	terazosin	66,75	CYP3A1	91,97	terazosin	CYP3A1	MESH:C041226	25642(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|nmod|END_ENTITY	Pharmacokinetic and pharmacodynamic consequences of inhibition of terazosin metabolism via CYP3A1 and/or 3A2 by DA-8159 , an erectogenic , in rats .
7903684	0	terazosin	41,50	alpha-1	19,26	terazosin	alpha-1	MESH:C041226	146	Chemical	Gene	antagonism|nmod|START_ENTITY antagonism|amod|END_ENTITY	Clinical effect of alpha-1 antagonism by terazosin on external and internal urinary sphincter function .
1654822	0	terbium	15,22	gelsolin	31,39	terbium	gelsolin	MESH:D013725	2934	Chemical	Gene	ions|compound|START_ENTITY ions|nmod|END_ENTITY	The binding of terbium ions to gelsolin reveals two classes of metal ion binding sites .
11480585	0	terbutaline	44,55	Beta1-adrenoceptor	0,18	terbutaline	Beta1-adrenoceptor	MESH:D013726	24925(Tax:10116)	Chemical	Gene	stimulation|nmod|START_ENTITY stimulation|amod|END_ENTITY	Beta1-adrenoceptor stimulation by high-dose terbutaline downregulates terbutaline-stimulated alveolar fluid clearance in ex vivo rat lung .
1347507	0	terbutaline	23,34	beta_2-adrenoceptor	38,57	terbutaline	beta 2-adrenoceptor	MESH:D013726	24176(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Hemodynamic effects of terbutaline , a beta_2-adrenoceptor agonist , in conscious rats with secondary_biliary_cirrhosis .
8921745	0	terbutaline	123,134	beta_2-adrenoceptor	15,34	terbutaline	beta 2-adrenoceptor	MESH:D013726	154	Chemical	Gene	assays|nmod|START_ENTITY development|nmod|assays application|nmod|development Interaction|dep|application Interaction|nmod|agonists agonists|amod|END_ENTITY	Interaction of beta_2-adrenoceptor agonists with native cyclodextrins : application to the development of chiral assays for terbutaline .
3410234	0	terbutaline	10,21	beta_2-adrenoreceptor	25,46	terbutaline	beta 2-adrenoreceptor	MESH:D013726	154	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Effect of terbutaline , a beta_2-adrenoreceptor agonist , on gastric acid secretion and serum gastrin concentrations in humans .
34369	0	terbutaline	11,22	erythropoietin	74,88	terbutaline	erythropoietin	MESH:D013726	13856(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|production production|compound|END_ENTITY	Effects of terbutaline , a synthetic beta adrenoceptor agonist , on in vivo erythropoietin production .
12365197	0	terfenadine	11,22	CYP2D6	50,56	terfenadine	CYP2D6	MESH:D016593	1565	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|compound|END_ENTITY	Effects of terfenadine and diphenhydramine on the CYP2D6 activity in healthy volunteers .
9013373	0	terfenadine	96,107	CYP3A	33,38	terfenadine	CYP3A	MESH:D016593	1576	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of dirithromycin on human CYP3A in vitro and on pharmacokinetics and pharmacodynamics of terfenadine in vivo .
9562230	0	terfenadine	50,61	CYP3A	8,13	terfenadine	CYP3A	MESH:D016593	1576	Chemical	Gene	Lack|nmod|START_ENTITY Lack|nmod|effects effects|nummod|END_ENTITY	Lack of CYP3A inhibition effects of sertindole on terfenadine in healthy volunteers .
9733666	0	terfenadine	15,26	cytochrome_P450_2D6	60,79	terfenadine	cytochrome P450 2D6	MESH:D016593	1565	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of terfenadine and its primary metabolites with cytochrome_P450_2D6 .
8112439	0	terfenadine	15,26	neurokinin_A	69,81	terfenadine	neurokinin A	MESH:D016593	6863	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of oral terfenadine on bronchoconstrictor response to inhaled neurokinin_A and histamine in asthmatic subjects .
1280680	0	terfenadine	10,21	substance_P	54,65	terfenadine	substance P	MESH:D016593	6863	Chemical	Gene	concentrations|amod|START_ENTITY Effect|nmod|concentrations Effect|nmod|END_ENTITY	Effect of terfenadine on the plasma concentrations of substance_P and vasoactive_intestinal_polypeptide in volunteers .
7515418	0	terfenadine	10,21	substance_P	25,36	terfenadine	substance P	MESH:D016593	6863	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|concentrations concentrations|compound|END_ENTITY	Effect of terfenadine on substance_P and vasoactive_intestinal_polypeptide concentrations in nasal secretions from patients with nasal_allergy .
9919714	0	terguride	180,189	GLUT-4	7,13	terguride	GLUT-4	MESH:C006208	25139(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY effect|nmod|treatment END_ENTITY|dep|effect	Muscle GLUT-4 and insulin binding to erythrocytes and to adipose , liver and muscle tissue in genetically hypertensive obese rats and in their lean siblings : effect of long lasting terguride treatment .
3709645	0	terguride	10,19	prolactin	23,32	terguride	prolactin	MESH:C006208	5617	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|compound|END_ENTITY	Effect of terguride on prolactin levels in normal , puerperal and hyperprolactinaemic women .
25053463	0	teriparatide	34,46	hip	62,65	teriparatide	hip	MESH:D019379	6159	Chemical	Gene	therapy|amod|START_ENTITY therapy|nmod|END_ENTITY	Literature review : The effects of teriparatide therapy at the hip in patients with osteoporosis .
15955217	0	terlipressin	60,72	somatostatin	11,23	terlipressin	somatostatin	MESH:C012078	6750	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of somatostatin , terlipressin and somatostatin plus terlipressin on portal and systemic hemodynamics and renal sodium excretion in patients with cirrhosis .
19664253	0	terlipressin	11,23	vasopressin	31,42	terlipressin	vasopressin	MESH:C012078	551	Chemical	Gene	START_ENTITY|nmod|infusion infusion|compound|END_ENTITY	Continuous terlipressin versus vasopressin infusion in septic_shock -LRB- TERLIVAP -RRB- : a randomized , controlled pilot study .
21080762	0	terlipressin	35,47	vasopressin	15,26	terlipressin	vasopressin	MESH:C012078	551	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|agonist agonist|compound|END_ENTITY	Effects of the vasopressin agonist terlipressin on plasma cAMP and ENaC excretion in the urine in patients with cirrhosis and water retention .
6123808	0	terlipressin	20,32	vasopressin	55,66	terlipressin	vasopressin	MESH:C012078	551	Chemical	Gene	trial|nmod|START_ENTITY trial|nmod|END_ENTITY	Controlled trial of terlipressin -LRB- ` Glypressin ' -RRB- versus vasopressin in the early treatment of oesophageal varices .
12618185	0	terpendole_E	18,30	Eg5	72,75	terpendole E	Eg5	MESH:C477863	3832	Chemical	Gene	action|nmod|START_ENTITY action|nmod|END_ENTITY	A novel action of terpendole_E on the motor activity of mitotic Kinesin Eg5 .
15231435	0	terpenes	32,40	arginine_vasopressin	82,102	terpenes	arginine vasopressin	MESH:D013729	24221(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of pretreatment with terpenes on transdermal iontophoretic delivery of arginine_vasopressin .
15789744	0	terpenoids	52,62	diacylglycerol_acyltransferase	18,48	terpenoids	diacylglycerol acyltransferase	MESH:D013729	84497(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	The inhibition of diacylglycerol_acyltransferase by terpenoids from Youngia koidzumiana .
24072200	0	terpestacin	37,48	endostatin	11,21	terpestacin	endostatin	MESH:C080890	80781	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of endostatin and a new drug terpestacin against human neuroblastoma xenograft and cell lines .
8627608	0	terphenyls	6,16	cyclooxygenase-2	30,46	terphenyls	cyclooxygenase-2	null	29527(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Novel terphenyls as selective cyclooxygenase-2 inhibitors and orally active anti-inflammatory agents .
19769382	0	terpyridine	114,125	and_1	127,132	terpyridine	and 1	null	11169	Chemical	Gene	properties|amod|START_ENTITY properties|amod|END_ENTITY	Synthesis , structures , spectroscopic and electrochemical properties of dinitrosyl_iron complexes with bipyridine , terpyridine , and_1 ,10 - phenathroline .
19493001	0	terrein	39,46	tyrosinase	25,35	terrein	tyrosinase	MESH:C439087	22173(Tax:10090)	Chemical	Gene	suppression|nmod|START_ENTITY suppression|nmod|END_ENTITY	Long-term suppression of tyrosinase by terrein via tyrosinase degradation and its decreased expression .
16581943	0	tert-butylhydroquinone	56,78	CYP1A1	14,20	tert-butylhydroquinone	CYP1A1	MESH:C018855	1543	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of CYP1A1 gene expression by the antioxidant tert-butylhydroquinone .
17676812	0	tert-butylhydroquinone	68,90	NF-E2_related_factor_2	0,22	tert-butylhydroquinone	NF-E2 related factor 2	MESH:C018855	83619(Tax:10116)	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	NF-E2_related_factor_2 activation and heme_oxygenase-1 induction by tert-butylhydroquinone protect against deltamethrin-mediated oxidative stress in PC12 cells .
2600595	0	tertiary_amines	17,32	cytochrome_P-450	52,68	tertiary amines	cytochrome P-450	CHEBI:32876	4051	Chemical	Gene	START_ENTITY|nmod|system system|amod|END_ENTITY	Demethylation of tertiary_amines by a reconstituted cytochrome_P-450 enzyme system : kinetics of oxygen consumption and hydrogen_peroxide formation .
20663044	0	tesmilifene	11,22	CYP3A	39,44	tesmilifene	CYP3A	MESH:C043062	170509(Tax:10116)	Chemical	Gene	START_ENTITY|appos|substrate substrate|nmod|END_ENTITY	Effects of tesmilifene , a substrate of CYP3A and an inhibitor of P-glycoprotein , on the pharmacokinetics of intravenous and oral docetaxel in rats .
15733480	0	testosterone	33,45	5-alpha-reductase	46,63	testosterone	5-alpha-reductase	MESH:D013739	6715	Chemical	Gene	factors|amod|START_ENTITY factors|amod|END_ENTITY	-LSB- Association of polymorphisms in testosterone 5-alpha-reductase II genotype and prognosis factors of prostate_cancer -RSB- .
10071856	0	testosterone	47,59	5_alpha-reductase	60,77	testosterone	5 alpha-reductase	MESH:D013739	6715	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Synthesis of 2-phenylbenzofuran derivatives as testosterone 5_alpha-reductase inhibitor .
11168798	0	testosterone	21,33	5_alpha-reductase	57,74	testosterone	5 alpha-reductase	MESH:D013739	6715	Chemical	Gene	roles|nmod|START_ENTITY roles|nmod|END_ENTITY	Biochemical roles of testosterone and epitestosterone to 5_alpha-reductase as indicators of male-pattern_baldness .
16386416	0	testosterone	22,34	5_alpha-reductase	89,106	testosterone	5 alpha-reductase	MESH:D013739	6715	Chemical	Gene	conversion|compound|START_ENTITY inhibited|nsubjpass|conversion inhibited|nmod|inhibitor inhibitor|amod|END_ENTITY	Aromatase-independent testosterone conversion into estrogenic_steroids is inhibited by a 5_alpha-reductase inhibitor .
19125422	0	testosterone	115,127	5_alpha-reductase	18,35	testosterone	5 alpha-reductase	MESH:D013739	6715	Chemical	Gene	concentrations|nmod|START_ENTITY increases|nmod|concentrations increases|nsubj|Overexpression Overexpression|nmod|type type|amod|END_ENTITY	Overexpression of 5_alpha-reductase type 1 increases sensitivity of prostate_cancer cells to low concentrations of testosterone .
2251223	0	testosterone	13,25	5_alpha-reductase	42,59	testosterone	5 alpha-reductase	MESH:D013739	6715	Chemical	Gene	availability|amod|START_ENTITY Reduction|nmod|availability Reduction|nmod|gland gland|amod|END_ENTITY	Reduction of testosterone availability to 5_alpha-reductase by human sex_hormone-binding_globulin in the rat ventral prostate gland in vivo .
2759905	0	testosterone	23,35	5_alpha-reductase	36,53	testosterone	5 alpha-reductase	MESH:D013739	6715	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	WS-9659_A_and_B , novel testosterone 5_alpha-reductase inhibitors isolated from a Streptomyces .
3411567	0	testosterone	138,150	5_alpha-reductase	16,33	testosterone	5 alpha-reductase	MESH:D013739	6715	Chemical	Gene	Distribution|nmod|START_ENTITY Distribution|nmod|END_ENTITY	Distribution of 5_alpha-reductase in the epididymis of the tammar wallaby -LRB- Macropus eugenii -RRB- and dependence of the epididymis on systemic testosterone and luminal fluids from the testis .
6746410	0	testosterone	67,79	5_alpha-reductase	14,31	testosterone	5 alpha-reductase	MESH:D013739	6715	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activity activity|amod|END_ENTITY	Inhibition of 5_alpha-reductase activity and alteration of nuclear testosterone .
7900170	0	testosterone	16,28	5_alpha-reductase	29,46	testosterone	5 alpha-reductase	MESH:D013739	6715	Chemical	Gene	Purification|nmod|START_ENTITY END_ENTITY|nsubj|Purification	Purification of testosterone 5_alpha-reductase from human prostate by a four-step chromatographic procedure .
8039530	0	testosterone	36,48	5_alpha-reductase	101,118	testosterone	5 alpha-reductase	MESH:D013739	6715	Chemical	Gene	metabolism|amod|START_ENTITY concentrations|nmod|metabolism concentrations|nmod|doses doses|nmod|MK-0434 MK-0434|appos|inhibitor inhibitor|amod|END_ENTITY	Plasma concentrations and effect on testosterone metabolism after single doses of MK-0434 , a steroid 5_alpha-reductase inhibitor , in healthy subjects .
8040353	0	testosterone	25,37	5_alpha-reductase	38,55	testosterone	5 alpha-reductase	MESH:D013739	6715	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Radioimmunoassay for the testosterone 5_alpha-reductase inhibitor turosteride in biological fluids .
8077349	0	testosterone	72,84	5_alpha-reductase	29,46	testosterone	5 alpha-reductase	MESH:D013739	6715	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|finasteride finasteride|appos|inhibitor inhibitor|amod|END_ENTITY	The effect of finasteride , a 5_alpha-reductase inhibitor , on scalp skin testosterone and dihydrotestosterone concentrations in patients with male pattern baldness .
8772548	2	testosterone	216,228	5_alpha-reductase	125,142	testosterone	5 alpha-reductase	MESH:D013739	6715	Chemical	Gene	doses|nmod|START_ENTITY administered|dobj|doses administered|nsubj|activity activity|amod|END_ENTITY	Higher 5_alpha-reductase activity in oligozoospermic men administered supraphysiological doses of testosterone .
9283948	1	testosterone	256,268	5_alpha-reductase	139,156	testosterone	5 alpha-reductase	MESH:D013739	6715	Chemical	Gene	doses|nmod|START_ENTITY administered|dobj|doses administered|nsubj|Localization Localization|nmod|activity activity|amod|END_ENTITY	V. Localization of higher 5_alpha-reductase activity to the reproductive tract in oligozoospermic men administered supraphysiological doses of testosterone .
10733498	0	testosterone	98,110	AR	121,123	testosterone	AR	MESH:D013739	367	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Human megakaryocytes and platelets contain the estrogen receptor beta and androgen_receptor -LRB- AR -RRB- : testosterone regulates AR expression .
8973559	10	testosterone	1567,1579	ATP	1560,1563	testosterone	Ca2	MESH:D013739	54231(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY END_ENTITY|nmod|secretion	The stimulatory effect of extracellular ATP on testosterone secretion seems to be coupled to the influx of Ca2 + from the external medium .
12865302	0	testosterone	48,60	Adrenocorticotropic_hormone	0,27	testosterone	Adrenocorticotropic hormone	MESH:D013739	18976(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Adrenocorticotropic_hormone directly stimulates testosterone production by the fetal and neonatal mouse testis .
11693406	0	testosterone	108,120	Androgen_receptor	0,17	testosterone	Androgen receptor	MESH:D013739	24208(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY increased|nmod|treatment increased|nsubjpass|immunoreactivity immunoreactivity|amod|END_ENTITY	Androgen_receptor immunoreactivity of male rat cervical motor neurons is increased by chronic pharmacologic testosterone treatment .
15212846	0	testosterone	49,61	Androgen_receptor	0,17	testosterone	Androgen receptor	MESH:D013739	11835(Tax:10090)	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|mRNA mRNA|compound|END_ENTITY	Androgen_receptor mRNA is inversely regulated by testosterone and estradiol in adult mouse brain .
18805913	0	testosterone	67,79	Androgen_receptor	0,17	testosterone	Androgen receptor	MESH:D013739	367	Chemical	Gene	leptin|compound|START_ENTITY associated|nmod|leptin associated|nsubjpass|polymorphism polymorphism|compound|END_ENTITY	Androgen_receptor CAG repeat polymorphism is associated with serum testosterone levels , obesity and serum leptin in men with type 2 diabetes .
21444647	0	testosterone	72,84	Androgen_receptor	0,17	testosterone	Androgen receptor	MESH:D013739	367	Chemical	Gene	impact|nmod|START_ENTITY modifies|dobj|impact modifies|nsubj|polymorphism polymorphism|compound|END_ENTITY	Androgen_receptor CAG repeat length polymorphism modifies the impact of testosterone on insulin sensitivity in men .
24593124	0	testosterone	111,123	Androgen_receptor	0,17	testosterone	Androgen receptor	MESH:D013739	367	Chemical	Gene	therapy|amod|START_ENTITY influences|nmod|therapy influences|nsubj|polymorphism polymorphism|compound|END_ENTITY	Androgen_receptor gene CAG repeat polymorphism independently influences recovery of male sexual function after testosterone replacement therapy in postsurgical hypogonadotropic_hypogonadism .
991826	0	testosterone	58,70	Androgen_receptor	0,17	testosterone	Androgen receptor	MESH:D013739	24208(Tax:10116)	Chemical	Gene	activities|nmod|START_ENTITY END_ENTITY|dobj|activities	Androgen_receptor dependent and independent activities of testosterone on hepatic microsomal drug metabolism .
26289400	0	testosterone	33,45	Annexin_A5	0,10	testosterone	Annexin A5	MESH:D013739	25673(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	Annexin_A5 regulates Leydig cell testosterone production via ERK1/2 pathway .
26289400	0	testosterone	33,45	Annexin_A5	0,10	testosterone	Annexin A5	MESH:D013739	25673(Tax:10116)	Chemical	Gene	production|compound|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	Annexin_A5 regulates Leydig cell testosterone production via ERK1/2 pathway .
2931293	0	testosterone	37,49	Atrial_natriuretic_factor	0,25	testosterone	Atrial natriuretic factor	MESH:D013739	230899(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Atrial_natriuretic_factor stimulates testosterone production by mouse interstitial cells .
10027289	0	testosterone	29,41	BDNF	0,4	testosterone	BDNF	MESH:D013739	627	Chemical	Gene	effects|nmod|START_ENTITY mediates|dobj|effects mediates|nsubj|END_ENTITY	BDNF mediates the effects of testosterone on the survival of new neurons in an adult brain .
26088421	0	testosterone	11,23	BDNF	35,39	testosterone	BDNF	MESH:D013739	627	Chemical	Gene	influences|nsubj|START_ENTITY influences|dobj|mRNA mRNA|compound|END_ENTITY	Adolescent testosterone influences BDNF and TrkB mRNA and neurotrophin-interneuron marker relationships in mammalian frontal cortex .
26753091	0	testosterone	67,79	BDNF	41,45	testosterone	BDNF	MESH:D013739	627	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|brain-derived_neurotrophic_factor brain-derived_neurotrophic_factor|appos|END_ENTITY	Serum brain-derived_neurotrophic_factor -LRB- BDNF -RRB- is not regulated by testosterone in transmen .
18728994	0	testosterone	45,57	Butyrylcholinesterase	0,21	testosterone	Butyrylcholinesterase	MESH:D013739	590	Chemical	Gene	activity|nmod|START_ENTITY END_ENTITY|dobj|activity	Butyrylcholinesterase inhibitory activity of testosterone and some of its metabolites .
17003308	0	testosterone	4,16	C-reactive_protein	26,44	testosterone	C-reactive protein	MESH:D013739	1401	Chemical	Gene	concentrations|amod|START_ENTITY concentrations|compound|END_ENTITY	Low testosterone and high C-reactive_protein concentrations predict low hematocrit in type 2 diabetes .
1731631	0	testosterone	172,184	CYP3A2	144,150	testosterone	CYP3A2	MESH:D013739	266682(Tax:10116)	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|gene gene|compound|END_ENTITY	Cloning and characterization of a novel CYP3A1 allelic variant : analysis of CYP3A1 and CYP3A2 sex-hormone-dependent expression reveals that the CYP3A2 gene is regulated by testosterone .
16245930	0	testosterone	38,50	CYP3A4	87,93	testosterone	CYP3A4	MESH:D013739	1576	Chemical	Gene	Cooperative|nmod|START_ENTITY Cooperative|nmod|site site|compound|END_ENTITY	Cooperative binding of midazolam with testosterone and alpha-naphthoflavone within the CYP3A4 active site : a NMR T1 paramagnetic relaxation study .
16855053	2	testosterone	919,931	CYP3A4	963,969	testosterone	CYP3A4	MESH:D013739	1576	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Using 16 individual human liver microsomes -LRB- HLMs -RRB- , a strong correlation was observed with endosulfan_sulfate formation and S-mephenytoin_N-demethylase activity of CYP2B6 -LRB- r -LRB- 2 -RRB- = 0.79 -RRB- , whereas a moderate correlation with testosterone 6 beta-hydroxylase activity of CYP3A4 -LRB- r -LRB- 2 -RRB- = 0.54 -RRB- was observed .
15232676	0	testosterone	69,81	CYP3A5	24,30	testosterone	CYP3A5	MESH:D013739	1577	Chemical	Gene	contribution|nmod|START_ENTITY contribution|nmod|END_ENTITY	Limited contribution of CYP3A5 to the hepatic 6beta-hydroxylation of testosterone .
7817804	0	testosterone	20,32	Calcitonin	0,10	testosterone	Calcitonin	MESH:D013739	24241(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY inhibits|dobj|secretion inhibits|nsubj|END_ENTITY	Calcitonin inhibits testosterone and luteinizing hormone secretion through a mechanism involving an increase in cAMP production in rats .
3593368	0	testosterone	41,53	Cytochrome_P-450	0,16	testosterone	Cytochrome P-450	MESH:D013739	25251(Tax:10116)	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|amod|END_ENTITY	Cytochrome_P-450 dependent metabolism of testosterone in rat skin .
12020745	0	testosterone	11,23	E-selectin	67,77	testosterone	E-selectin	MESH:D013739	6401	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of testosterone and 17-beta-estradiol on TNF-alpha-induced E-selectin and VCAM-1 expression in endothelial cells .
26289400	0	testosterone	33,45	ERK1/2	61,67	testosterone	ERK1/2	MESH:D013739	50689;116590	Chemical	Gene	production|compound|START_ENTITY production|nmod|pathway pathway|compound|END_ENTITY	Annexin_A5 regulates Leydig cell testosterone production via ERK1/2 pathway .
26289400	0	testosterone	33,45	ERK1/2	61,67	testosterone	ERK1/2	MESH:D013739	50689;116590	Chemical	Gene	production|compound|START_ENTITY production|nmod|pathway pathway|compound|END_ENTITY	Annexin_A5 regulates Leydig cell testosterone production via ERK1/2 pathway .
8126153	0	testosterone	26,38	Erythropoietin	0,14	testosterone	Erythropoietin	MESH:D013739	2056	Chemical	Gene	production|amod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Erythropoietin stimulates testosterone production in man .
22265242	0	testosterone	122,134	Extracellular_signal-regulated_kinase_2	0,39	testosterone	Extracellular signal-regulated kinase 2	MESH:D013739	116590(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY mediates|dobj|effects mediates|nsubj|END_ENTITY	Extracellular_signal-regulated_kinase_2 signaling in the hippocampal dentate gyrus mediates the antidepressant effects of testosterone .
14512439	0	testosterone	116,128	FSH-beta	149,157	testosterone	FSH-beta	MESH:D013739	25447(Tax:10116)	Chemical	Gene	transcription|compound|START_ENTITY transcription|compound|END_ENTITY	Regulation of luteinizing hormone-beta and follicle-stimulating_hormone _ -LRB- FSH -RRB- - beta gene transcription by androgens : testosterone directly stimulates FSH-beta transcription independent from its role on follistatin gene expression .
12196551	0	testosterone	105,117	Fab	85,88	testosterone	Fab	MESH:D013739	2187	Chemical	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Crystal structure of an in vitro affinity - and specificity-matured anti-testosterone Fab in complex with testosterone .
16157456	0	testosterone	4,16	Fos	25,28	testosterone	Fos	MESH:D013739	101831721	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	ICV testosterone induces Fos in male Syrian_hamster brain .
14689884	0	testosterone	12,24	GDNF	28,32	testosterone	GDNF	MESH:D013739	25453(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	-LSB- Effects of testosterone on GDNF mRNA expression in rat ventral prostate -RSB- .
19383805	0	testosterone	76,88	GGN	43,46	testosterone	GGN	MESH:D013739	199720	Chemical	Gene	levels|compound|START_ENTITY END_ENTITY|nmod|levels	Small effect of the androgen_receptor gene GGN repeat polymorphism on serum testosterone levels in healthy men .
10803589	0	testosterone	143,155	GalR1	14,19	testosterone	GalR1	MESH:D013739	50577(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY Expression|dep|effect Expression|nmod|END_ENTITY	Expression of GalR1 and GalR2 galanin receptor messenger ribonucleic acid in proopiomelanocortin neurons of the rat arcuate nucleus : effect of testosterone .
12000543	0	testosterone	89,101	GnRH	112,116	testosterone	GnRH	MESH:D013739	101832723	Chemical	Gene	groups|nmod|START_ENTITY regulates|nsubj|groups regulates|dobj|mRNA mRNA|compound|END_ENTITY	Redefining gonadotropin-releasing_hormone -LRB- GnRH -RRB- cell groups in the male Syrian_hamster : testosterone regulates GnRH mRNA in the tenia tecta .
12000543	0	testosterone	89,101	GnRH	43,47	testosterone	GnRH	MESH:D013739	101832723	Chemical	Gene	groups|nmod|START_ENTITY groups|appos|END_ENTITY	Redefining gonadotropin-releasing_hormone -LRB- GnRH -RRB- cell groups in the male Syrian_hamster : testosterone regulates GnRH mRNA in the tenia tecta .
14665718	1	testosterone	69,81	GnRH	111,115	testosterone	GnRH	MESH:D013739	25194(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Long-term changes in plasma testosterone regulation , but no effect on GnRH gene expression or plasma LH concentrations .
15062545	0	testosterone	59,71	GnRH	34,38	testosterone	GnRH	MESH:D013739	101832723	Chemical	Gene	feedback|amod|START_ENTITY END_ENTITY|nmod|feedback	Increased expression of forebrain GnRH mRNA and changes in testosterone negative feedback following pubertal maturation .
1906089	0	testosterone	28,40	GnRH	78,82	testosterone	GnRH	MESH:D013739	2796	Chemical	Gene	administration|nmod|START_ENTITY Effect|nmod|administration Effect|appos|END_ENTITY	Effect of administration of testosterone and gonadotrophin-releasing_hormone -LRB- GnRH -RRB- antagonist on basal and GnRH-stimulated gonadotrophin secretion in orchidectomized monkeys .
19479252	0	testosterone	110,122	GnRH	27,31	testosterone	GnRH	MESH:D013739	2796	Chemical	Gene	serum|xcomp|START_ENTITY serum|nsubj|administration administration|nmod|acyline acyline|compound|END_ENTITY	Oral administration of the GnRH antagonist acyline , in a GIPET-enhanced tablet form , acutely suppresses serum testosterone in normal men : single-dose pharmacokinetics and pharmacodynamics .
20735905	0	testosterone	12,24	GnRH	73,77	testosterone	GnRH	MESH:D013739	2796	Chemical	Gene	suppression|amod|START_ENTITY Analysis|nmod|suppression receiving|nsubj|Analysis END_ENTITY|advcl|receiving	Analysis of testosterone suppression in men receiving histrelin , a novel GnRH agonist for the treatment of prostate_cancer .
21829476	0	testosterone	29,41	GnRH	0,4	testosterone	GnRH	MESH:D013739	2796	Chemical	Gene	concentrations|amod|START_ENTITY link|nmod|concentrations END_ENTITY|dep|link	GnRH -- a missing link between testosterone concentrations in yolk and plasma and its intergenerational effects .
21986087	0	testosterone	21,33	GnRH	117,121	testosterone	GnRH	MESH:D013739	2796	Chemical	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Non-breeding gonadal testosterone production of male and female northern cardinals -LRB- Cardinalis cardinalis -RRB- following GnRH challenge .
2987065	0	testosterone	99,111	GnRH	142,146	testosterone	GnRH	MESH:D013739	25194(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY stimulated|nsubjpass|production stimulated|nmod|agonist agonist|compound|END_ENTITY	Newborn and immature rat testes contain gonadotropin-releasing_hormone -LRB- GnRH -RRB- receptors , and their testosterone production is stimulated by a GnRH agonist in vitro .
3098014	0	testosterone	60,72	GnRH	11,15	testosterone	GnRH	MESH:D013739	2796	Chemical	Gene	concentrations|nmod|START_ENTITY inhibit|dobj|concentrations analogue|xcomp|inhibit analogue|nsubj|Failure Failure|nmod|END_ENTITY	Failure of GnRH analogue to inhibit serum concentrations of testosterone and 17 alpha-hydroxyprogesterone in hCG-substituted hypogonadotropic_hypogonadism .
6086288	0	testosterone	170,182	GnRH	70,74	testosterone	GnRH	MESH:D013739	25194(Tax:10116)	Chemical	Gene	modulate|nsubj|START_ENTITY inhibition|dep|modulate responses|dep|inhibition responses|nmod|END_ENTITY	Pituitary gonadotropin-releasing_hormone -LRB- GnRH -RRB- receptor responses to GnRH in hypothalamus-lesioned rats : inhibition of responses by hyperprolactinemia and evidence that testosterone and estradiol modulate gonadotropin secretion at postreceptor sites .
6409594	2	testosterone	685,697	GnRH	654,658	testosterone	GnRH	MESH:D013739	25194(Tax:10116)	Chemical	Gene	secretion|compound|START_ENTITY enhanced|dobj|secretion enhanced|nsubj|END_ENTITY	GnRH and HOE766 enhanced basal testosterone secretion by freshly isolated or cultured Leydig cells .
6809782	0	testosterone	57,69	GnRH	27,31	testosterone	GnRH	MESH:D013739	2796	Chemical	Gene	production|amod|START_ENTITY induction|nmod|production pulsatile|nmod|induction pulsatile|dobj|therapy therapy|amod|END_ENTITY	Chronic pulsatile low dose GnRH therapy for induction of testosterone production and spermatogenesis in a man with secondary hypogonadotropic_hypogonadism .
7810447	0	testosterone	14,26	GnRH	66,70	testosterone	GnRH	MESH:D013739	2796	Chemical	Gene	response|amod|START_ENTITY Evaluation|nmod|response Evaluation|acl|intramuscular intramuscular|dobj|injection injection|nmod|END_ENTITY	Evaluation of testosterone response to intramuscular injection of GnRH and its correlation with sperm quality parameters in cockerels .
8410806	0	testosterone	43,55	GnRH	79,83	testosterone	GnRH	MESH:D013739	25194(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|rats rats|acl|treated treated|nmod|antagonist antagonist|compound|END_ENTITY	Maintenance of spermiogenesis by exogenous testosterone in rats treated with a GnRH antagonist : relationship with androgen-binding_protein status .
9246946	0	testosterone	37,49	GnRH	55,59	testosterone	GnRH	MESH:D013739	2796	Chemical	Gene	START_ENTITY|nmod|antagonist antagonist|compound|END_ENTITY	Blockade of the neonatal increase in testosterone by a GnRH antagonist : the free androgen index , reproductive capacity and postmortem findings in the male marmoset monkey .
17202804	0	testosterone	56,68	Gonadotropin-releasing_hormone	0,30	testosterone	Gonadotropin-releasing hormone	MESH:D013739	2796	Chemical	Gene	START_ENTITY|nsubj|antagonizes antagonizes|amod|END_ENTITY	Gonadotropin-releasing_hormone functionally antagonizes testosterone activation of the human androgen_receptor in prostate cells through focal adhesion complexes involving Hic-5 .
23954356	0	testosterone	38,50	Growth_differential_factor-9	0,28	testosterone	Growth differential factor-9	MESH:D013739	14566(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Growth_differential_factor-9 inhibits testosterone production in mouse theca interstitial cells .
10943734	0	testosterone	35,47	Growth_hormone	0,14	testosterone	Growth hormone	MESH:D013739	81668(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Growth_hormone directly stimulates testosterone and oestradiol secretion by rat Leydig cells in vitro and modulates the effects of LH and T3 .
16353427	0	testosterone	31,43	Growth_hormone	0,14	testosterone	Growth hormone	MESH:D013739	2688	Chemical	Gene	administration|amod|START_ENTITY secretion|nmod|administration secretion|nsubj|END_ENTITY	Growth_hormone secretion after testosterone administration to men with visceral_obesity .
192755	0	testosterone	31,43	HCG	0,3	testosterone	HCG	MESH:D013739	3342	Chemical	Gene	biosynthesis|amod|START_ENTITY binding|nmod|biosynthesis END_ENTITY|dobj|binding	HCG binding and stimulation of testosterone biosynthesis in the human fetal testis .
12519859	0	testosterone	36,48	HOXA-10	14,21	testosterone	HOXA-10	MESH:D013739	3206	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of HOXA-10 expression by testosterone in vitro and in the endometrium of patients with polycystic_ovary_syndrome .
7690721	0	testosterone	18,30	HS-142-1	0,8	testosterone	HS-142-1	MESH:D013739	4240936(Tax:205914)	Chemical	Gene	production|amod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	HS-142-1 inhibits testosterone production and guanosine-3 ' :5 ' - cyclic_monophosphate accumulation stimulated by atrial_natriuretic_peptide in isolated mouse Leydig cells .
8971550	0	testosterone	10,22	IGF-I	67,72	testosterone	IGF-I	MESH:D013739	3479	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|END_ENTITY	Effect of testosterone on binding of insulin-like_growth_factor-I -LRB- IGF-I -RRB- and IGF-II in growing antlers of fallow deer -LRB- Dama dama -RRB- .
6279190	0	testosterone	24,36	Insulin	0,7	testosterone	Insulin	MESH:D013739	3630	Chemical	Gene	production|amod|START_ENTITY augmentation|nmod|production augmentation|compound|END_ENTITY	Insulin augmentation of testosterone production in a primary culture of rat testicular cells .
7852532	0	testosterone	18,30	Insulin	0,7	testosterone	Insulin	MESH:D013739	3630	Chemical	Gene	concentrations|amod|START_ENTITY regulates|dobj|concentrations regulates|nsubj|END_ENTITY	Insulin regulates testosterone and sex_hormone-binding_globulin concentrations in adult normal weight and obese men .
9626131	0	testosterone	19,31	Insulin	0,7	testosterone	Insulin	MESH:D013739	3630	Chemical	Gene	biosynthesis|amod|START_ENTITY stimulates|dobj|biosynthesis stimulates|nsubj|END_ENTITY	Insulin stimulates testosterone biosynthesis by human thecal cells from women with polycystic_ovary_syndrome by activating its own receptor and using inositolglycan mediators as the signal transduction system .
22800961	0	testosterone	34,46	Insulin-like_peptide_3	0,22	testosterone	Insulin-like peptide 3	MESH:D013739	281870(Tax:9913)	Chemical	Gene	secretion|amod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Insulin-like_peptide_3 stimulates testosterone secretion in mouse Leydig cells via cAMP pathway .
10668786	0	testosterone	34,46	L-plastin	16,25	testosterone	L-plastin	MESH:D013739	3936	Chemical	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Upregulation of L-plastin gene by testosterone in breast and prostate_cancer cells : identification of three cooperative androgen_receptor-binding sequences .
3426339	0	testosterone	24,36	LDH-X	15,20	testosterone	LDH-X	MESH:D013739	3948	Chemical	Gene	therapy|amod|START_ENTITY END_ENTITY|nmod|therapy	Seminal plasma LDH-X in testosterone rebound therapy .
37185	0	testosterone	59,71	LH-RH	20,25	testosterone	LH-RH	MESH:D013739	2796	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of synthetic LH-RH and hCG administration on plasma testosterone , androstenedione , and estradiol 17beta levels in normal men and in patients with idiopathic oligospermia .
22399012	0	testosterone	20,32	LH-releasing_hormone	74,94	testosterone	LH-releasing hormone	MESH:D013739	2796	Chemical	Gene	START_ENTITY|nmod|therapy therapy|amod|END_ENTITY	Variations of serum testosterone levels in prostate_cancer patients under LH-releasing_hormone therapy : an open question .
10320818	0	testosterone	16,28	Leptin	0,6	testosterone	Leptin	MESH:D013739	25608(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY inhibits|dobj|secretion inhibits|nsubj|END_ENTITY	Leptin inhibits testosterone secretion from adult rat testis in vitro .
11786597	0	testosterone	81,93	Leptin	0,6	testosterone	Leptin	MESH:D013739	3952	Chemical	Gene	mediated|nmod|START_ENTITY interactions|acl|mediated results|nmod|interactions results|nsubj|dimorphism dimorphism|nmod:poss|END_ENTITY	Leptin 's sexual dimorphism results from genotype by sex interactions mediated by testosterone .
17441374	0	testosterone	167,179	Leptin	1,7	testosterone	Leptin	MESH:D013739	3952	Chemical	Gene	level|amod|START_ENTITY women|nmod|level correlates|nmod|women correlates|nsubj|END_ENTITY	-LSB- Leptin correlates with distribution of fatty tissue and plasma levels of insulin , testosterone and tumor_necrosis_factor_alpha in perimenopausal women with increased testosterone level and central location of body fat -RSB- .
18462615	0	testosterone	55,67	Leptin	0,6	testosterone	Leptin	MESH:D013739	16846(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Leptin inhibits basal but not gonadotrophin-stimulated testosterone production in the immature mouse and sheep testis .
24829619	0	testosterone	68,80	Leptin	0,6	testosterone	Leptin	MESH:D013739	16846(Tax:10090)	Chemical	Gene	contribute|nmod|START_ENTITY contribute|nsubj|level level|compound|END_ENTITY	Leptin level and oxidative stress contribute to obesity-induced low testosterone in murine testicular tissue .
6987051	0	testosterone	55,67	Luteinizing_hormone-releasing_hormone	0,37	testosterone	Luteinizing hormone-releasing hormone	MESH:D013739	25194(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY inhibit|dobj|production inhibit|nsubj|END_ENTITY	Luteinizing_hormone-releasing_hormone does not inhibit testosterone production in rat interstitial cells in vitro .
8724182	0	testosterone	11,23	MENT	63,67	testosterone	MENT	MESH:D013739	229588(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of testosterone and 7 alpha-methyl-19-nortestosterone -LRB- MENT -RRB- on sexual and aggressive_behaviors in two inbred strains of male mice .
10639190	0	testosterone	56,68	Mitochondrial_aconitase	0,23	testosterone	Mitochondrial aconitase	MESH:D013739	50	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	Mitochondrial_aconitase gene expression is regulated by testosterone and prolactin in prostate epithelial cells .
21072693	0	testosterone	22,34	NSSR1	0,5	testosterone	NSSR1	MESH:D013739	14105(Tax:10090)	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	NSSR1 is regulated by testosterone in the mouse uterus and extensively expressed in endometrial_carcinoma .
12709396	0	testosterone	13,25	ODC	43,46	testosterone	ODC	MESH:D013739	18263(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Influence of testosterone on regulation of ODC , antizyme , and N1-SSAT gene expression in mouse kidney .
3092827	0	testosterone	61,73	Ornithine_decarboxylase	0,23	testosterone	Ornithine decarboxylase	MESH:D013739	18263(Tax:10090)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Ornithine_decarboxylase activity and actin polymerization in testosterone -- stimulated mouse kidney .
23315980	0	testosterone	31,43	Osteocalcin	0,11	testosterone	Osteocalcin	MESH:D013739	12097(Tax:10090)	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	Osteocalcin is associated with testosterone in the general population and selected patients with bone_disorders .
23696116	0	testosterone	49,61	Osteocalcin	0,11	testosterone	Osteocalcin	MESH:D013739	12097(Tax:10090)	Chemical	Gene	determinant|nmod|START_ENTITY determinant|nsubj|END_ENTITY	Osteocalcin is not a strong determinant of serum testosterone and sperm count in men from infertile couples .
24691732	0	testosterone	84,96	Osteocalcin	0,11	testosterone	Osteocalcin	MESH:D013739	12097(Tax:10090)	Chemical	Gene	synthesis|amod|START_ENTITY promoting|dobj|synthesis system|acl|promoting induces|dep|system induces|nsubj|END_ENTITY	Osteocalcin induces growth_hormone / insulin-like growth factor-1 system by promoting testosterone synthesis in male mice .
22746349	0	testosterone	11,23	P2Y12	91,96	testosterone	P2Y12	MESH:D013739	64805	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of testosterone and 17b-oestradiol on expression of the G protein-coupled receptor P2Y12 in megakaryocytic DAMI cells .
26517944	0	testosterone	17,29	PACAP	8,13	testosterone	PACAP	MESH:D013739	116	Chemical	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	Role of PACAP on testosterone and 17b-estradiol production in the testis of wall lizard Podarcis_sicula .
17507429	0	testosterone	61,73	PKCdelta	0,8	testosterone	PKCdelta	MESH:D013739	5580	Chemical	Gene	effects|nmod|START_ENTITY mediates|dobj|effects mediates|nsubj|END_ENTITY	PKCdelta mediates anti-proliferative , pro-apoptic effects of testosterone on coronary smooth muscle .
18843272	0	testosterone	47,59	PSA	33,36	testosterone	PSA	MESH:D013739	354	Chemical	Gene	START_ENTITY|nsubj|Correlation Correlation|nmod|END_ENTITY	Correlation between simultaneous PSA and serum testosterone concentrations among eugonadal , untreated hypogonadal and hypogonadal men receiving testosterone replacement therapy .
2126608	0	testosterone	75,87	Pro-opiomelanocortin	0,20	testosterone	Pro-opiomelanocortin	MESH:D013739	24664(Tax:10116)	Chemical	Gene	increased|nmod|START_ENTITY increased|nsubjpass|RNA RNA|compound|END_ENTITY	Pro-opiomelanocortin messenger RNA in hypothalamic neurons is increased by testosterone through aromatization to estradiol .
2453860	0	testosterone	78,90	Prolactin	0,9	testosterone	Prolactin	MESH:D013739	5617	Chemical	Gene	prostate|xcomp|START_ENTITY prostate|nsubj|effect effect|compound|END_ENTITY	Prolactin effect on the permeability of human benign hyperplastic prostate to testosterone .
2744187	0	testosterone	67,79	Prolactin	0,9	testosterone	Prolactin	MESH:D013739	5617	Chemical	Gene	aromatization|nmod|START_ENTITY stimulates|dobj|aromatization stimulates|nsubj|suppression suppression|compound|END_ENTITY	Prolactin suppression by bromocriptine stimulates aromatization of testosterone to estradiol in women .
3100279	0	testosterone	81,93	Prolactin	0,9	testosterone	Prolactin	MESH:D013739	24683(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY modulates|nmod|effect modulates|nsubj|END_ENTITY	Prolactin modulates the gonadotropin response to the negative feedback effect of testosterone in immature male rats .
11675466	0	testosterone	27,39	Prostate-specific_antigen	0,25	testosterone	Prostate-specific antigen	MESH:D013739	354	Chemical	Gene	globulin|amod|START_ENTITY globulin|amod|END_ENTITY	Prostate-specific_antigen , testosterone , sex-hormone binding globulin and androgen_receptor CAG repeat polymorphisms in subfertile and normal men .
12399540	0	testosterone	66,78	Prostate-specific_antigen	0,25	testosterone	Prostate-specific antigen	MESH:D013739	354	Chemical	Gene	replacement|amod|START_ENTITY treated|nmod|replacement treated|nsubj|changes changes|amod|END_ENTITY	Prostate-specific_antigen changes in hypogonadal men treated with testosterone replacement .
19154450	0	testosterone	86,98	Prostate-specific_antigen	0,25	testosterone	Prostate-specific antigen	MESH:D013739	354	Chemical	Gene	therapy|amod|START_ENTITY treated|nmod|therapy treated|nsubj|changes changes|amod|END_ENTITY	Prostate-specific_antigen changes and prostate_cancer in hypogonadal men treated with testosterone replacement therapy .
7682197	0	testosterone	77,89	Prostate-specific_antigen	0,25	testosterone	Prostate-specific antigen	MESH:D013739	354	Chemical	Gene	START_ENTITY|nsubj|size size|amod|END_ENTITY	Prostate-specific_antigen and prostate gland size in men receiving exogenous testosterone for male contraception .
12712319	0	testosterone	11,23	Reelin	27,33	testosterone	Reelin	MESH:D013739	19699(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of testosterone on Reelin expression in the brain of male European starlings .
2949473	0	testosterone	42,54	SBP	36,39	testosterone	SBP	MESH:D013739	8991	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Sex-steroid-binding plasma protein -LRB- SBP -RRB- , testosterone , oestradiol and dehydroepiandrosterone -LRB- DHEA -RRB- in prepuberty and puberty .
3142652	0	testosterone	74,86	SBP	102,105	testosterone	SBP	MESH:D013739	8991	Chemical	Gene	protein|nmod|START_ENTITY site|nmod|protein Identification|nmod|site Identification|appos|END_ENTITY	-LSB- Identification of a photolabelled site of the plasma binding protein for testosterone and estradiol -LRB- SBP -RRB- using tritiated_17_beta-hydroxy - _ 4,6-androstadien-3-one -RSB- .
3927063	0	testosterone	96,108	SBP	46,49	testosterone	SBP	MESH:D013739	100009224(Tax:9986)	Chemical	Gene	rate|nmod|START_ENTITY plasma|nmod|rate effect|nmod|plasma effect|appos|END_ENTITY	Direct effect of sex steroid-binding protein -LRB- SBP -RRB- of plasma on the metabolic clearance rate of testosterone in the rhesus_macaque .
17932133	0	testosterone	174,186	SHBG	198,202	testosterone	SHBG	MESH:D013739	6462	Chemical	Gene	START_ENTITY|amod|binding binding|nmod|END_ENTITY	Determination of bioavailable testosterone -LSB- non sex_hormone_binding_globulin -LRB- SHBG -RRB- - bound testosterone -RSB- in a population of healthy French men : influence of androstenediol on testosterone binding to SHBG .
9673455	0	testosterone	143,155	STAR	54,58	testosterone	STAR	MESH:D013739	6770	Chemical	Gene	secretion|amod|START_ENTITY associated|nmod|secretion associated|nsubj|Changes Changes|nmod|steroidogenic_acute_regulatory steroidogenic_acute_regulatory|appos|END_ENTITY	Changes in testicular steroidogenic_acute_regulatory -LRB- STAR -RRB- protein , steroidogenic enzymes and testicular morphology associated with increased testosterone secretion in bulls receiving the luteinizing hormone releasing hormone agonist deslorelin .
24327369	0	testosterone	113,125	Sex_Hormone-Binding_Globulin	49,77	testosterone	Sex Hormone-Binding Globulin	MESH:D013739	6462	Chemical	Gene	related|nmod|START_ENTITY related|nsubj|polymorphism polymorphism|appos|rs1799941 rs1799941|nmod|gene gene|amod|END_ENTITY	Single-nucleotide polymorphism , rs1799941 in the Sex_Hormone-Binding_Globulin -LRB- SHBG -RRB- gene , related to both serum testosterone and SHBG levels and the risk of myocardial_infarction , type 2 diabetes , cancer and mortality in men : the Troms Study .
6684473	0	testosterone	40,52	Sex_hormone-binding_globulin	0,28	testosterone	Sex hormone-binding globulin	MESH:D013739	6462	Chemical	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	Sex_hormone-binding_globulin and saliva testosterone levels in men with androgenetic_alopecia .
2860769	0	testosterone	41,53	Sex_hormone_binding_globulin	0,28	testosterone	Sex hormone binding globulin	MESH:D013739	6462	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Sex_hormone_binding_globulin response to testosterone .
1979839	0	testosterone	67,79	Somatostatin	0,12	testosterone	Somatostatin	MESH:D013739	24797(Tax:10116)	Chemical	Gene	increased|nmod|START_ENTITY increased|nsubjpass|RNA RNA|compound|END_ENTITY	Somatostatin messenger RNA in hypothalamic neurons is increased by testosterone through activation of androgen receptors and not by aromatization to estradiol .
10220047	0	testosterone	117,129	StAR	51,55	testosterone	StAR	MESH:D013739	25557(Tax:10116)	Chemical	Gene	production|amod|START_ENTITY regulation|nmod|production implications|nmod|regulation Down-regulation|dep|implications Down-regulation|nmod|protein protein|appos|END_ENTITY	Down-regulation of steroidogenic_acute_regulatory -LRB- StAR -RRB- protein in rat Leydig cells : implications for regulation of testosterone production during aging .
10220309	0	testosterone	30,42	StAR	79,83	testosterone	StAR	MESH:D013739	25557(Tax:10116)	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Sepsis produces depression of testosterone and steroidogenic_acute_regulatory -LRB- StAR -RRB- protein .
19862501	0	testosterone	46,58	StAR	88,92	testosterone	StAR	MESH:D013739	20845(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|synthesis synthesis|acl|downregulating downregulating|dobj|END_ENTITY	Cypermethrin exposure during puberty disrupts testosterone synthesis via downregulating StAR in mouse testes .
21076439	0	testosterone	25,37	StAR	67,71	testosterone	StAR	MESH:D013739	25557(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|mRNA mRNA|compound|END_ENTITY	Effects of varicocele on testosterone , apoptosis and expression of StAR mRNA in rat Leydig cells .
22960446	0	testosterone	66,78	StAR	116,120	testosterone	StAR	MESH:D013739	25557(Tax:10116)	Chemical	Gene	acetylation|amod|START_ENTITY acetylation|nmod|promoter promoter|compound|END_ENTITY	Neonatal exposure to benzo -LSB- a -RSB- pyrene decreases the levels of serum testosterone and histone H3K14 acetylation of the StAR promoter in the testes of SD rats .
26975478	0	testosterone	163,175	StAR	125,129	testosterone	StAR	MESH:D013739	20845(Tax:10090)	Chemical	Gene	production|nmod|START_ENTITY reduce|dobj|production testes|xcomp|reduce testes|dobj|acetylation acetylation|nmod|promoter promoter|compound|END_ENTITY	Exposure of preimplantation embryos to low-dose bisphenol_A impairs testes development and suppresses histone acetylation of StAR promoter to reduce production of testosterone in mice .
8828518	0	testosterone	28,40	StAR	104,108	testosterone	StAR	MESH:D013739	6770	Chemical	Gene	inhibition|nmod|START_ENTITY Acute|nmod|inhibition parallels|nsubj|Acute parallels|dobj|loss loss|nmod|protein protein|appos|END_ENTITY	Acute in vivo inhibition of testosterone by endotoxin parallels loss of steroidogenic_acute_regulatory -LRB- StAR -RRB- protein in Leydig cells .
2843722	0	testosterone	19,31	TBG	41,44	testosterone	TBG	MESH:D013739	6906	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nsubj|effect	The effect of oral testosterone on serum TBG levels in alcoholic cirrhotic men .
21960045	0	testosterone	11,23	TNF-a	54,59	testosterone	TNF-a	MESH:D013739	24835(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of testosterone , estrogen and progesterone on TNF-a mediated cellular damage in rat arthritic synovial fibroblasts .
26996389	0	testosterone	8,20	TNF-a	48,53	testosterone	TNF-a	MESH:D013739	24835(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of testosterone in regulating induction of TNF-a in rat spleen via ERK signaling pathway .
18337309	0	testosterone	48,60	VEGF	86,90	testosterone	VEGF	MESH:D013739	83785(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Deleterious effects of endogenous and exogenous testosterone on mesenchymal stem cell VEGF production .
11133688	0	testosterone	11,23	ZPC	77,80	testosterone	ZPC	MESH:D013739	7784	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of testosterone on production of perivitelline membrane glycoprotein ZPC by granulosa cells of Japanese_quail -LRB- Coturnix_japonica -RRB- .
11133688	7	testosterone	1385,1397	ZPC	1336,1339	testosterone	ZPC	MESH:D013739	7784	Chemical	Gene	culture|nmod|START_ENTITY high|nmod|culture high|nsubj|expression expression|compound|END_ENTITY	By measuring ZPC protein and mRNA with Western and Northern blot analyses , respectively , we found that addition of testosterone maintained ZPC contents in the culture of the granulosa cells , and that ZPC mRNA expression was high in the culture with testosterone compared to the control .
22939588	0	testosterone	44,56	adiponectin	27,38	testosterone	adiponectin	MESH:D013739	9370	Chemical	Gene	circulating|nmod|START_ENTITY circulating|dobj|END_ENTITY	Association of circulating adiponectin with testosterone in women during the menopausal transition .
6320915	0	testosterone	107,119	adrenocorticotropic_hormone	74,101	testosterone	adrenocorticotropic hormone	MESH:D013739	5443	Chemical	Gene	production|amod|START_ENTITY mediate|nmod|production mediate|dobj|effect effect|nmod|END_ENTITY	Ability of cortisol and progesterone to mediate the stimulatory effect of adrenocorticotropic_hormone upon testosterone production by the porcine testis .
10503713	0	testosterone	68,80	androgen_receptor	105,122	testosterone	androgen receptor	MESH:D013739	24208(Tax:10116)	Chemical	Gene	accumulation|amod|START_ENTITY accumulation|nmod|mRNA mRNA|compound|END_ENTITY	Autoregulation of the androgen_receptor at the translational level : testosterone induces accumulation of androgen_receptor mRNA in the rat ventral prostate polyribosomes .
10503713	0	testosterone	68,80	androgen_receptor	22,39	testosterone	androgen receptor	MESH:D013739	24208(Tax:10116)	Chemical	Gene	accumulation|amod|START_ENTITY Autoregulation|dep|accumulation Autoregulation|nmod|END_ENTITY	Autoregulation of the androgen_receptor at the translational level : testosterone induces accumulation of androgen_receptor mRNA in the rat ventral prostate polyribosomes .
11597306	0	testosterone	248,260	androgen_receptor	14,31	testosterone	androgen receptor	MESH:D013739	100401612	Chemical	Gene	concentrations|amod|START_ENTITY increase|nmod|concentrations immunoexpression|nmod|increase immunoexpression|nsubj|Comparison Comparison|nmod|beta beta|compound|END_ENTITY	Comparison of androgen_receptor and oestrogen receptor beta immunoexpression in the testes of the common_marmoset -LRB- Callithrix_jacchus -RRB- from birth to adulthood : low androgen_receptor immunoexpression in Sertoli cells during the neonatal increase in testosterone concentrations .
11597306	0	testosterone	248,260	androgen_receptor	164,181	testosterone	androgen receptor	MESH:D013739	100401612	Chemical	Gene	concentrations|amod|START_ENTITY increase|nmod|concentrations immunoexpression|nmod|increase immunoexpression|nmod|cells cells|amod|adulthood adulthood|dep|immunoexpression immunoexpression|compound|END_ENTITY	Comparison of androgen_receptor and oestrogen receptor beta immunoexpression in the testes of the common_marmoset -LRB- Callithrix_jacchus -RRB- from birth to adulthood : low androgen_receptor immunoexpression in Sertoli cells during the neonatal increase in testosterone concentrations .
11708214	0	testosterone	60,72	androgen_receptor	34,51	testosterone	androgen receptor	MESH:D013739	11835(Tax:10090)	Chemical	Gene	Amplification|nmod|START_ENTITY Amplification|nmod|gene gene|compound|END_ENTITY	Amplification of exons 4 and 5 of androgen_receptor gene by testosterone in aged female mouse brain cortex .
11738558	0	testosterone	92,104	androgen_receptor	32,49	testosterone	androgen receptor	MESH:D013739	24208(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY Properties|dep|effect Properties|nmod|END_ENTITY	Properties of free and occupied androgen_receptor in rat skeletal muscle cytosol : effect of testosterone .
1315310	0	testosterone	10,22	androgen_receptor	56,73	testosterone	androgen receptor	MESH:D013739	24208(Tax:10116)	Chemical	Gene	deprivation|amod|START_ENTITY Effect|nmod|deprivation Effect|nmod|END_ENTITY	Effect of testosterone deprivation on expression of the androgen_receptor in rat prostate , epididymis and testis .
14609562	0	testosterone	16,28	androgen_receptor	74,91	testosterone	androgen receptor	MESH:D013739	24208(Tax:10116)	Chemical	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|expression expression|compound|END_ENTITY	Interactions of testosterone and all-trans_retinoic_acid in regulation of androgen_receptor expression in rat lacrimal gland .
15090305	0	testosterone	11,23	androgen_receptor	41,58	testosterone	androgen receptor	MESH:D013739	367	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of testosterone on expression of androgen_receptor in human monocytic cell line THP-1 -RSB- .
1551811	0	testosterone	14,26	androgen_receptor	143,160	testosterone	androgen receptor	MESH:D013739	11835(Tax:10090)	Chemical	Gene	Evidence|acl:relcl|START_ENTITY regulates|nsubj|Evidence regulates|xcomp|Leydig Leydig|nmod|END_ENTITY	Evidence that testosterone regulates Leydig cell 3_beta-hydroxysteroid dehydrogenase-isomerase activity by a trans-acting factor distal to the androgen_receptor .
15771997	0	testosterone	52,64	androgen_receptor	15,32	testosterone	androgen receptor	MESH:D013739	24208(Tax:10116)	Chemical	Gene	cells|amod|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	-LSB- Regulation of androgen_receptor mRNA expression by testosterone in cultured vascular smooth muscle cells -RSB- .
15774258	0	testosterone	89,101	androgen_receptor	33,50	testosterone	androgen receptor	MESH:D013739	367	Chemical	Gene	level|compound|START_ENTITY combined|nmod|level combined|nsubj|length length|nmod|gene gene|compound|END_ENTITY	CAG polymorphic repeat length in androgen_receptor gene combined with pretreatment serum testosterone level as prognostic factor in patients with metastatic_prostate_cancer .
1659875	0	testosterone	70,82	androgen_receptor	14,31	testosterone	androgen receptor	MESH:D013739	24208(Tax:10116)	Chemical	Gene	testis|nmod|START_ENTITY testis|nsubj|Regulation Regulation|nmod|mRNA mRNA|compound|END_ENTITY	Regulation of androgen_receptor mRNA and protein in the rat testis by testosterone .
16793958	0	testosterone	56,68	androgen_receptor	4,21	testosterone	androgen receptor	MESH:D013739	367	Chemical	Gene	impact|nmod|START_ENTITY modifies|dobj|impact modifies|nsubj|repeat repeat|amod|END_ENTITY	The androgen_receptor CAG repeat modifies the impact of testosterone on insulin resistance in women with polycystic_ovary_syndrome .
17202804	0	testosterone	56,68	androgen_receptor	93,110	testosterone	androgen receptor	MESH:D013739	367	Chemical	Gene	START_ENTITY|dobj|activation activation|nmod|END_ENTITY	Gonadotropin-releasing_hormone functionally antagonizes testosterone activation of the human androgen_receptor in prostate cells through focal adhesion complexes involving Hic-5 .
17322500	0	testosterone	17,29	androgen_receptor	67,84	testosterone	androgen receptor	MESH:D013739	367	Chemical	Gene	effect|nmod|START_ENTITY modulated|nsubj|effect modulated|nmod|CAG CAG|compound|END_ENTITY	Is the effect of testosterone on body composition modulated by the androgen_receptor gene CAG repeat polymorphism in elderly men ?
17579205	0	testosterone	47,59	androgen_receptor	171,188	testosterone	androgen receptor	MESH:D013739	367	Chemical	Gene	levels|compound|START_ENTITY variation|nmod|levels Part|nmod|variation reflects|nsubj|Part reflects|parataxis|contribution contribution|nmod|polymorphism polymorphism|compound|END_ENTITY	Part of the interindividual variation in serum testosterone levels in healthy men reflects differences in androgen sensitivity and feedback set point : contribution of the androgen_receptor polyglutamine tract polymorphism .
17591767	0	testosterone	57,69	androgen_receptor	14,31	testosterone	androgen receptor	MESH:D013739	367	Chemical	Gene	function|nmod|START_ENTITY function|nsubj|Modulation Modulation|nmod|activation activation|compound|END_ENTITY	Modulation of androgen_receptor activation function 2 by testosterone and dihydrotestosterone .
17659846	0	testosterone	6,18	androgen_receptor	20,37	testosterone	androgen receptor	MESH:D013739	367	Chemical	Gene	START_ENTITY|appos|polymorphism polymorphism|compound|END_ENTITY	Total testosterone , androgen_receptor polymorphism , and depressive_symptoms in young black and white men : the CARDIA Male Hormone Study .
19383805	0	testosterone	76,88	androgen_receptor	20,37	testosterone	androgen receptor	MESH:D013739	367	Chemical	Gene	levels|compound|START_ENTITY GGN|nmod|levels GGN|nsubj|effect effect|nmod|gene gene|compound|END_ENTITY	Small effect of the androgen_receptor gene GGN repeat polymorphism on serum testosterone levels in healthy men .
19429451	0	testosterone	20,32	androgen_receptor	66,83	testosterone	androgen receptor	MESH:D013739	367	Chemical	Gene	START_ENTITY|ccomp|potentiate potentiate|dobj|responses responses|compound|END_ENTITY	Elevated endogenous testosterone concentrations potentiate muscle androgen_receptor responses to resistance exercise .
19608712	0	testosterone	111,123	androgen_receptor	72,89	testosterone	androgen receptor	MESH:D013739	367	Chemical	Gene	synthesis|nmod|START_ENTITY activate|nmod|synthesis activate|dobj|END_ENTITY	Prostate_cancer stromal cells and LNCaP cells coordinately activate the androgen_receptor through synthesis of testosterone and dihydrotestosterone from dehydroepiandrosterone .
19620824	0	testosterone	70,82	androgen_receptor	16,33	testosterone	androgen receptor	MESH:D013739	367	Chemical	Gene	desire|amod|START_ENTITY relation|nmod|desire sensitivity|nmod|relation sensitivity|compound|END_ENTITY	Contribution of androgen_receptor sensitivity to the relation between testosterone and sexual desire : An exploration in male-to-female transsexuals .
21224128	0	testosterone	163,175	androgen_receptor	35,52	testosterone	androgen receptor	MESH:D013739	24208(Tax:10116)	Chemical	Gene	dimethyl-4-aminobiphenyl|nmod|START_ENTITY induced|dep|dimethyl-4-aminobiphenyl carcinogenesis|dep|induced demonstrated|nmod|carcinogenesis demonstrated|dobj|expression expression|compound|END_ENTITY	Immunohistochemically demonstrated androgen_receptor expression in the rat prostate during carcinogenesis induced by 3,2 ' - dimethyl-4-aminobiphenyl with or without testosterone .
21536043	0	testosterone	64,76	androgen_receptor	85,102	testosterone	androgen receptor	MESH:D013739	422165(Tax:9031)	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|expression expression|compound|END_ENTITY	Examining a pathway for hormone mediated maternal effects -- yolk testosterone affects androgen_receptor expression and endogenous testosterone production in young chicks -LRB- Gallus_gallus_domesticus -RRB- .
21950564	0	testosterone	76,88	androgen_receptor	4,21	testosterone	androgen receptor	MESH:D013739	367	Chemical	Gene	factor|nmod|START_ENTITY CAG|nmod|factor CAG|nsubj|END_ENTITY	The androgen_receptor CAG repeat polymorphism as a risk factor of low serum testosterone and its cardiometabolic effects in men .
22429282	0	testosterone	99,111	androgen_receptor	14,31	testosterone	androgen receptor	MESH:D013739	367	Chemical	Gene	levels|compound|START_ENTITY symptoms|nmod|levels CAG|nmod|symptoms CAG|nsubj|impact impact|nmod|END_ENTITY	The impact of androgen_receptor CAG repeat polymorphism on andropausal symptoms in different serum testosterone levels .
22546276	0	testosterone	25,37	androgen_receptor	69,86	testosterone	androgen receptor	MESH:D013739	24208(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY mediated|nsubjpass|effect mediated|nmod|END_ENTITY	The anxiolytic effect of testosterone in the rat is mediated via the androgen_receptor .
23808476	0	testosterone	26,38	androgen_receptor	155,172	testosterone	androgen receptor	MESH:D013739	367	Chemical	Gene	Fertility|nmod|START_ENTITY Fertility|nmod|mutation mutation|compound|END_ENTITY	Fertility after high-dose testosterone and intracytoplasmic sperm injection in a patient with androgen_insensitivity_syndrome with a previously unreported androgen_receptor mutation .
23811403	0	testosterone	89,101	androgen_receptor	46,63	testosterone	androgen receptor	MESH:D013739	11835(Tax:10090)	Chemical	Gene	downregulated|nmod|START_ENTITY END_ENTITY|acl:relcl|downregulated	Ankrd1 is a transcriptional repressor for the androgen_receptor that is downregulated by testosterone .
24458833	0	testosterone	11,23	androgen_receptor	137,154	testosterone	androgen receptor	MESH:D013739	367	Chemical	Gene	therapy|amod|START_ENTITY Effects|nmod|therapy Effects|dep|focus focus|nmod|role role|nmod|polymorphism polymorphism|compound|END_ENTITY	Effects of testosterone replacement therapy on bone metabolism in male post-surgical hypogonadotropic_hypogonadism : focus on the role of androgen_receptor CAG polymorphism .
24750035	0	testosterone	75,87	androgen_receptor	16,33	testosterone	androgen receptor	MESH:D013739	367	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|role role|nmod|END_ENTITY	Crucial role of androgen_receptor in vascular H2_S biosynthesis induced by testosterone .
24787905	0	testosterone	99,111	androgen_receptor	149,166	testosterone	androgen receptor	MESH:D013739	367	Chemical	Gene	therapy|amod|START_ENTITY undergoing|dobj|therapy affected|xcomp|undergoing men|acl|affected changes|nmod|men modulated|nsubjpass|changes modulated|nmod|polymorphism polymorphism|compound|END_ENTITY	Central body fat changes in men affected by post-surgical hypogonadotropic_hypogonadism undergoing testosterone replacement therapy are modulated by androgen_receptor CAG polymorphism .
25011927	0	testosterone	66,78	androgen_receptor	83,100	testosterone	androgen receptor	MESH:D013739	11835(Tax:10090)	Chemical	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|activation activation|compound|END_ENTITY	Up-regulation of hepatic alpha-2-HS-glycoprotein transcription by testosterone via androgen_receptor activation .
2503662	0	testosterone	75,87	androgen_receptor	101,118	testosterone	androgen receptor	MESH:D013739	11835(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY mediated|dobj|effects mediated|nmod|FSH FSH|acl|using using|dobj|deficient deficient|compound|END_ENTITY	Differentiation between androgen and estrogen receptor mediated effects of testosterone on FSH using androgen_receptor deficient -LRB- Tfm -RRB- and normal mice .
446378	0	testosterone	157,169	androgen_receptor	24,41	testosterone	androgen receptor	MESH:D013739	24208(Tax:10116)	Chemical	Gene	levels|nmod|START_ENTITY radioimmunoassay|nmod|levels based|nmod|radioimmunoassay based|nsubj|Characterization Characterization|nmod|END_ENTITY	Characterization of the androgen_receptor in nuclei of seminiferous tubules of the mature male rat based upon radioimmunoassay of endogenous levels of bound testosterone .
6605848	0	testosterone	63,75	androgen_receptor	21,38	testosterone	androgen receptor	MESH:D013739	367	Chemical	Gene	Changes|nmod|START_ENTITY Changes|nmod|END_ENTITY	Changes in cytosolic androgen_receptor after administration of testosterone of androgen-dependent mouse mammary_tumor -LRB- Shionogi_carcinoma -RRB- and its sublines of altered androgen dependency .
6891012	0	testosterone	31,43	androgen_receptor	109,126	testosterone	androgen receptor	MESH:D013739	24208(Tax:10116)	Chemical	Gene	affinities|nmod|START_ENTITY affinities|nmod|END_ENTITY	Relative binding affinities of testosterone , 19-nortestosterone and their 5 alpha-reduced derivatives to the androgen_receptor and to other androgen-binding proteins : a suggested role of 5 alpha-reductive steroid metabolism in the dissociation of `` myotropic '' and `` androgenic '' activities of 19-nortestosterone .
7160340	0	testosterone	21,33	androgen_receptor	99,116	testosterone	androgen receptor	MESH:D013739	24208(Tax:10116)	Chemical	Gene	Different|nmod|START_ENTITY Different|nmod|END_ENTITY	Different binding of testosterone , 19-nortestosterone and their 5 alpha-reduced derivatives to the androgen_receptor of the rat seminal vesicle : a step toward the understanding of the anabolic action of nortesterone .
7472260	0	testosterone	10,22	androgen_receptor	30,47	testosterone	androgen receptor	MESH:D013739	24208(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of testosterone on the androgen_receptor in the liver cytosol and nuclei of castrated male rats .
7599695	0	testosterone	53,65	androgen_receptor	13,30	testosterone	androgen receptor	MESH:D013739	11835(Tax:10090)	Chemical	Gene	concentration|nmod|START_ENTITY concentration|compound|END_ENTITY	Reduction of androgen_receptor mRNA concentration by testosterone in mouse submandibular gland .
7733645	0	testosterone	63,75	androgen_receptor	16,33	testosterone	androgen receptor	MESH:D013739	24208(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nmod|effect	Mediation by an androgen_receptor of the stimulatory effect of testosterone on the growth of a fibrosarcoma in the rat .
7826887	0	testosterone	46,58	androgen_receptor	4,21	testosterone	androgen receptor	MESH:D013739	24208(Tax:10116)	Chemical	Gene	up-regulated|nmod|START_ENTITY up-regulated|nsubjpass|mRNA mRNA|compound|END_ENTITY	The androgen_receptor mRNA is up-regulated by testosterone in both the Harderian_gland_and_thumb_pad of the frog , Rana esculenta .
7997435	0	testosterone	57,69	androgen_receptor	141,158	testosterone	androgen receptor	MESH:D013739	11835(Tax:10090)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|acl|transfected transfected|nmod|cDNA cDNA|compound|END_ENTITY	Inhibition of growth and increase of acid phosphatase by testosterone on androgen-independent murine prostatic_cancer cells transfected with androgen_receptor cDNA .
8737842	0	testosterone	27,39	androgen_receptor	108,125	testosterone	androgen receptor	MESH:D013739	422165(Tax:9031)	Chemical	Gene	effects|nmod|START_ENTITY appears|nsubj|effects appears|xcomp|mediated mediated|nmod|END_ENTITY	The suppressive effects of testosterone on growth in young chickens appears to be mediated via a peripheral androgen_receptor ; studies of the anti-androgen ICI_176 ,334 .
1916212	0	testosterone	42,54	arginine_vasotocin	20,38	testosterone	arginine vasotocin	MESH:D013739	100301660(Tax:8022)	Chemical	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	In vitro effects of arginine_vasotocin on testosterone production by testes of rainbow_trout -LRB- Oncorhynchus_mykiss -RRB- .
2224502	0	testosterone	46,58	beta-subunit_of_nerve_growth_factor	80,115	testosterone	beta-subunit of nerve growth factor	MESH:D013739	18049(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|levels levels|nmod|END_ENTITY	Influences of neonatal and adult exposures to testosterone on the levels of the beta-subunit_of_nerve_growth_factor in the neural tissues of mice .
26753091	0	testosterone	67,79	brain-derived_neurotrophic_factor	6,39	testosterone	brain-derived neurotrophic factor	MESH:D013739	627	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Serum brain-derived_neurotrophic_factor -LRB- BDNF -RRB- is not regulated by testosterone in transmen .
10870222	0	testosterone	11,23	carboxypeptidase_H	44,62	testosterone	carboxypeptidase H	MESH:D013739	12876(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	-LSB- Effect of testosterone and progesterone on carboxypeptidase_H activity in the hypothalamo-hypophyseal-gonadal_axis and the adrenal gland in mice -RSB- .
10979568	0	testosterone	11,23	carboxypeptidase_H	27,45	testosterone	carboxypeptidase H	MESH:D013739	12876(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	-LSB- Effect of testosterone on carboxypeptidase_H activity in the murine hypothalamus and hypophysis -RSB- .
12587273	0	testosterone	11,23	carboxypeptidase_H	44,62	testosterone	carboxypeptidase H	MESH:D013739	12876(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	-LSB- Effect of testosterone and progesterone on carboxypeptidase_H activity during stress in mice -RSB- .
1356736	1	testosterone	54,66	cytochrome_P-450	90,106	testosterone	cytochrome P-450	MESH:D013739	25251(Tax:10116)	Chemical	Gene	metabolite|compound|START_ENTITY produced|nsubj|metabolite produced|nmod|2A2 2A2|amod|END_ENTITY	A hitherto unidentified testosterone metabolite produced by cytochrome_P-450 2A2 .
1881602	0	testosterone	18,30	cytochrome_P-450	87,103	testosterone	cytochrome P-450	MESH:D013739	25251(Tax:10116)	Chemical	Gene	Administration|nmod|START_ENTITY alleviates|nsubj|Administration alleviates|xcomp|END_ENTITY	Administration of testosterone alleviates the constitutive sex difference in rat brain cytochrome_P-450 .
2460437	0	testosterone	77,89	cytochrome_P-450	136,152	testosterone	cytochrome P-450	MESH:D013739	25251(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|forms forms|nmod|microsomes microsomes|amod|END_ENTITY	Immunochemical evidence for the catalysis of vitamin_D3 25-hydroxylation and testosterone 16 alpha-hydroxylation by homologous forms of cytochrome_P-450 in rat liver microsomes .
2747039	0	testosterone	87,99	cytochrome_P-450	25,41	testosterone	cytochrome P-450	MESH:D013739	4051	Chemical	Gene	hydroxylases|amod|START_ENTITY antibodies|nmod|hydroxylases inhibition|nmod|antibodies homology|dep|inhibition homology|nmod|END_ENTITY	Interspecies homology of cytochrome_P-450 : inhibition by anti-P-450-male antibodies of testosterone hydroxylases in liver microsomes from various animal species including man .
2752981	0	testosterone	64,76	cytochrome_P-450	22,38	testosterone	cytochrome P-450	MESH:D013739	25251(Tax:10116)	Chemical	Gene	oxidation|amod|START_ENTITY responsible|nmod|oxidation isozymes|amod|responsible isozymes|amod|END_ENTITY	Identification of the cytochrome_P-450 isozymes responsible for testosterone oxidation in rat lung , kidney , and testis : evidence that cytochrome_P-450a -LRB- P450IIA1 -RRB- is the physiologically important testosterone_7_alpha-hydroxylase in rat testis .
3109324	0	testosterone	42,54	cytochrome_P-450	128,144	testosterone	cytochrome P-450	MESH:D013739	25251(Tax:10116)	Chemical	Gene	hydroxylation|amod|START_ENTITY factor|nmod|hydroxylation Studies|nmod|factor Studies|dep|evidence evidence|nmod|isozyme isozyme|amod|END_ENTITY	Studies on the rate-determining factor in testosterone hydroxylation by rat liver microsomal cytochrome_P-450 : evidence against cytochrome_P-450 isozyme : isozyme interactions .
3109324	0	testosterone	42,54	cytochrome_P-450	93,109	testosterone	cytochrome P-450	MESH:D013739	25251(Tax:10116)	Chemical	Gene	hydroxylation|amod|START_ENTITY hydroxylation|nmod|liver liver|amod|END_ENTITY	Studies on the rate-determining factor in testosterone hydroxylation by rat liver microsomal cytochrome_P-450 : evidence against cytochrome_P-450 isozyme : isozyme interactions .
3429444	0	testosterone	56,68	cytochrome_P-450	28,44	testosterone	cytochrome P-450	MESH:D013739	4051	Chemical	Gene	START_ENTITY|nsubj|Purification Purification|nmod|catalyzing catalyzing|amod|END_ENTITY	Purification of human liver cytochrome_P-450 catalyzing testosterone 6 beta-hydroxylation .
3592665	0	testosterone	14,26	cytochrome_P-450	65,81	testosterone	cytochrome P-450	MESH:D013739	25251(Tax:10116)	Chemical	Gene	hydroxylation|amod|START_ENTITY Regulation|nmod|hydroxylation microsomal|nsubj|Regulation microsomal|xcomp|END_ENTITY	Regulation of testosterone hydroxylation by rat liver microsomal cytochrome_P-450 .
3937894	0	testosterone	138,150	cytochrome_P-450	20,36	testosterone	cytochrome P-450	MESH:D013739	25251(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY pentachlorobiphenyl|dep|metabolism microsomes|parataxis|pentachlorobiphenyl microsomes|nsubj|induction induction|nmod|isozymes isozymes|amod|END_ENTITY	Unique induction of cytochrome_P-450 isozymes in rat liver microsomes by treatment with 3,4,5,3 ' ,4 ' - pentachlorobiphenyl and its effect on testosterone metabolism .
6335714	0	testosterone	9,21	cytochrome_P-450	99,115	testosterone	cytochrome P-450	MESH:D013739	25251(Tax:10116)	Chemical	Gene	imprinting|compound|START_ENTITY imprinting|nmod|END_ENTITY	Neonatal testosterone imprinting of hepatic microsomal drug metabolism and a male-specific form of cytochrome_P-450 in the rat .
7281573	0	testosterone	43,55	cytochrome_P-450	72,88	testosterone	cytochrome P-450	MESH:D013739	25251(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|induction induction|nmod|END_ENTITY	-LSB- Effect of the long-term administration of testosterone on induction of cytochrome_P-450 in female rat live tissue using phenobarbital -RSB- .
7545987	0	testosterone	48,60	cytochrome_P-450	19,35	testosterone	cytochrome P-450	MESH:D013739	25251(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY Effects|nmod|metabolism Effects|nmod|inducers inducers|amod|END_ENTITY	Effects of various cytochrome_P-450 inducers on testosterone metabolism and several monooxygenase activities in Sprague-Dawley -LRB- SpD -RRB- , high alcohol sensitivity -LRB- HAS -RRB- and low alcohol sensitivity -LRB- LAS -RRB- rats .
20945304	0	testosterone	37,49	cytochrome_P450	6,21	testosterone	cytochrome P450	MESH:D013739	4051	Chemical	Gene	metabolism|nmod|START_ENTITY END_ENTITY|dep|metabolism	Human cytochrome_P450 : metabolism of testosterone by CYP3A4 and inhibition by ketoconazole .
1428205	0	testosterone	100,112	erythropoietin	28,42	testosterone	erythropoietin	MESH:D013739	2056	Chemical	Gene	therapy|dobj|START_ENTITY therapy|nsubj|Effect Effect|nmod|END_ENTITY	Effect of recombinant human erythropoietin -LRB- r-HuEPO -RRB- therapy on plasma FT3 , FT4 , TSH , FSH , LH , free testosterone and prolactin levels in hemodialysis patients .
15735242	0	testosterone	46,58	erythropoietin	115,129	testosterone	erythropoietin	MESH:D013739	2056	Chemical	Gene	reduces|dobj|START_ENTITY reduces|nmod|resistance resistance|compound|END_ENTITY	Renin-angiotensin blockade reduces serum free testosterone in middle-aged men on haemodialysis and correlates with erythropoietin resistance .
2123018	0	testosterone	99,111	erythropoietin	13,27	testosterone	erythropoietin	MESH:D013739	2056	Chemical	Gene	START_ENTITY|nsubj|Influence Influence|nmod|treatment treatment|compound|END_ENTITY	Influence of erythropoietin treatment on follitropin and lutropin response to luliberin and plasma testosterone levels in haemodialyzed patients .
23258626	0	testosterone	32,44	erythropoietin	57,71	testosterone	erythropoietin	MESH:D013739	2056	Chemical	Gene	effect|nmod|START_ENTITY mediated|nsubj|effect mediated|nmod|END_ENTITY	Is the haematopoietic effect of testosterone mediated by erythropoietin ?
871411	0	testosterone	10,22	erythropoietin	41,55	testosterone	erythropoietin	MESH:D013739	13856(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|production production|compound|END_ENTITY	Effect of testosterone and oestradiol on erythropoietin production in vitro .
744008	0	testosterone	10,22	estradiol_receptor	47,65	testosterone	estradiol receptor	MESH:D013739	24890(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of testosterone and progesterone on the estradiol_receptor in the immature rat ovary .
21204602	0	testosterone	19,31	ghrelin	8,15	testosterone	ghrelin	MESH:D013739	59301(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY END_ENTITY|nmod|secretion	Role of ghrelin on testosterone secretion and the mRNA expression of androgen_receptors in adult rat testis .
23843820	0	testosterone	30,42	ghrelin	65,72	testosterone	ghrelin	MESH:D013739	442996(Tax:9940)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|concentration concentration|compound|END_ENTITY	Effect of interaction between testosterone and morphine on serum ghrelin concentration in sheep fed on different dietary energy levels .
10692858	0	testosterone	59,71	gonadotrophin-releasing_hormone	14,45	testosterone	gonadotrophin-releasing hormone	MESH:D013739	443529(Tax:9940)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|secretion secretion|amod|END_ENTITY	Regulation of gonadotrophin-releasing_hormone secretion by testosterone in male sheep .
3009677	0	testosterone	10,22	gonadotrophin-releasing_hormone	26,57	testosterone	gonadotrophin-releasing hormone	MESH:D013739	25194(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|receptors receptors|amod|END_ENTITY	Effect of testosterone on gonadotrophin-releasing_hormone receptors in the castrated rat : preliminary evidence for a stimulatory effect of testosterone on gonadotrophin function in the male rat .
3009677	0	testosterone	139,151	gonadotrophin-releasing_hormone	26,57	testosterone	gonadotrophin-releasing hormone	MESH:D013739	25194(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY evidence|nmod|effect Effect|dep|evidence Effect|nmod|testosterone testosterone|nmod|receptors receptors|amod|END_ENTITY	Effect of testosterone on gonadotrophin-releasing_hormone receptors in the castrated rat : preliminary evidence for a stimulatory effect of testosterone on gonadotrophin function in the male rat .
335759	0	testosterone	15,27	gonadotrophin-releasing_hormone	94,125	testosterone	gonadotrophin-releasing hormone	MESH:D013739	25194(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY responsiveness|nsubj|effects responsiveness|nmod|END_ENTITY	The effects of testosterone and its 5alpha-reduced metabolites on pituitary responsiveness to gonadotrophin-releasing_hormone -LRB- Gn-RH -RRB- .
6092174	0	testosterone	46,58	gonadotrophin-releasing_hormone	11,42	testosterone	gonadotrophin-releasing hormone	MESH:D013739	25194(Tax:10116)	Chemical	Gene	secretion|amod|START_ENTITY END_ENTITY|nmod|secretion	Effects of gonadotrophin-releasing_hormone on testosterone secretion by fetal and neonatal rat testes in vitro .
7964300	0	testosterone	4,16	gonadotrophin-releasing_hormone	36,67	testosterone	gonadotrophin-releasing hormone	MESH:D013739	2796	Chemical	Gene	maintain|nsubj|START_ENTITY maintain|dobj|suppression suppression|amod|END_ENTITY	Can testosterone alone maintain the gonadotrophin-releasing_hormone antagonist-induced suppression of spermatogenesis in the non-human primate ?
10077358	0	testosterone	24,36	gonadotropin-releasing_hormone	72,102	testosterone	gonadotropin-releasing hormone	MESH:D013739	2796	Chemical	Gene	Pharmacokinetics|nmod|START_ENTITY transdermal|nsubj|Pharmacokinetics transdermal|dobj|systems systems|nmod|men men|amod|END_ENTITY	Pharmacokinetics of new testosterone transdermal therapeutic systems in gonadotropin-releasing_hormone antagonist-suppressed normal men .
12000543	0	testosterone	89,101	gonadotropin-releasing_hormone	11,41	testosterone	gonadotropin-releasing hormone	MESH:D013739	101832723	Chemical	Gene	groups|nmod|START_ENTITY groups|amod|END_ENTITY	Redefining gonadotropin-releasing_hormone -LRB- GnRH -RRB- cell groups in the male Syrian_hamster : testosterone regulates GnRH mRNA in the tenia tecta .
1370794	0	testosterone	11,23	gonadotropin-releasing_hormone	106,136	testosterone	gonadotropin-releasing hormone	MESH:D013739	2796	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|presence presence|nmod|END_ENTITY	Effects of testosterone on gonadotropin subunit messenger ribonucleic acids in the presence or absence of gonadotropin-releasing_hormone .
15994752	0	testosterone	158,170	gonadotropin-releasing_hormone	101,131	testosterone	gonadotropin-releasing hormone	MESH:D013739	2796	Chemical	Gene	absence|nmod|START_ENTITY receiving|nmod|absence receiving|dobj|agonist agonist|amod|END_ENTITY	High dose estrogen treatment increases bone mineral density in male-to-female transsexuals receiving gonadotropin-releasing_hormone agonist in the absence of testosterone .
1633910	0	testosterone	85,97	gonadotropin-releasing_hormone	24,54	testosterone	gonadotropin-releasing hormone	MESH:D013739	25194(Tax:10116)	Chemical	Gene	implants|amod|START_ENTITY Immunoneutralization|nmod|implants Immunoneutralization|nmod|treatment treatment|amod|END_ENTITY	Immunoneutralization of gonadotropin-releasing_hormone and subsequent treatment with testosterone Silastic implants in rats : an approach toward developing a male contraceptive .
17179469	0	testosterone	28,40	gonadotropin-releasing_hormone	120,150	testosterone	gonadotropin-releasing hormone	MESH:D013739	25194(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|model model|acl|treated treated|nmod|degarelix degarelix|appos|antagonist antagonist|amod|END_ENTITY	Rapid suppression of plasma testosterone levels and tumor growth in the dunning rat model treated with degarelix , a new gonadotropin-releasing_hormone antagonist .
18082732	0	testosterone	101,113	gonadotropin-releasing_hormone	26,56	testosterone	gonadotropin-releasing hormone	MESH:D013739	2796	Chemical	Gene	START_ENTITY|nsubj|Transcripts Transcripts|nmod|END_ENTITY	Transcripts of testicular gonadotropin-releasing_hormone , steroidogenic enzymes , and intratesticular testosterone levels in infertile men .
1898888	0	testosterone	40,52	gonadotropin-releasing_hormone	80,110	testosterone	gonadotropin-releasing hormone	MESH:D013739	2796	Chemical	Gene	START_ENTITY|nmod|analog analog|nmod|END_ENTITY	Marked suppression of gonadotropins and testosterone by an antagonist analog of gonadotropin-releasing_hormone in men .
20357176	0	testosterone	142,154	gonadotropin-releasing_hormone	30,60	testosterone	gonadotropin-releasing hormone	MESH:D013739	2796	Chemical	Gene	clamp|compound|START_ENTITY luteinizing|nmod|clamp stimulation|acl|luteinizing stimulation|nmod:poss|END_ENTITY	Age in men does not determine gonadotropin-releasing_hormone 's dose-dependent stimulation of luteinizing hormone secretion under an exogenous testosterone clamp .
2085971	0	testosterone	37,49	gonadotropin-releasing_hormone	65,95	testosterone	gonadotropin-releasing hormone	MESH:D013739	2796	Chemical	Gene	secretion|amod|START_ENTITY suppression|nmod|secretion Single|dobj|suppression Single|nmod|antagonist antagonist|amod|END_ENTITY	Single dose long-term suppression of testosterone secretion by a gonadotropin-releasing_hormone antagonist -LRB- Antide -RRB- in male monkeys .
3103502	0	testosterone	105,117	gonadotropin-releasing_hormone	143,173	testosterone	gonadotropin-releasing hormone	MESH:D013739	2796	Chemical	Gene	secretion|amod|START_ENTITY secretion|nmod|response response|nmod|gonadotropin gonadotropin|amod|END_ENTITY	Effects of zeranol on reproduction in beef bulls : luteinizing hormone , follicle-stimulating hormone , and testosterone secretion in response to gonadotropin-releasing_hormone and human chorionic gonadotropin .
3138274	0	testosterone	28,40	gonadotropin-releasing_hormone	93,123	testosterone	gonadotropin-releasing hormone	MESH:D013739	2796	Chemical	Gene	suppression|nmod|START_ENTITY suppression|nmod|leuprolide leuprolide|amod|END_ENTITY	Differential suppression of testosterone and estradiol in hirsute women with the superactive gonadotropin-releasing_hormone agonist leuprolide .
3143542	0	testosterone	179,191	gonadotropin-releasing_hormone	61,91	testosterone	gonadotropin-releasing hormone	MESH:D013739	2796	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nmod|effect	Endogenous human growth_hormone -LRB- GH -RRB- modulates the effect of gonadotropin-releasing_hormone on pituitary function and the gonadotropin response to the negative feedback effect of testosterone in adult male transgenic_mice bearing human GH gene .
3293986	0	testosterone	74,86	gonadotropin-releasing_hormone	138,168	testosterone	gonadotropin-releasing hormone	MESH:D013739	2796	Chemical	Gene	responses|amod|START_ENTITY infusions|nmod|responses infusions|xcomp|LH LH|nmod|rams rams|acl|immunized immunized|nmod|END_ENTITY	Effects of pulsatile and continuous luteinizing hormone -LRB- LH -RRB- infusions on testosterone responses to LH in rams actively immunized against gonadotropin-releasing_hormone .
3918288	0	testosterone	102,114	gonadotropin-releasing_hormone	36,66	testosterone	gonadotropin-releasing hormone	MESH:D013739	2796	Chemical	Gene	treatment|compound|START_ENTITY Evidence|nmod|treatment Evidence|nmod|END_ENTITY	Evidence for decreased secretion of gonadotropin-releasing_hormone in pubertal boys during short-term testosterone treatment .
8158519	0	testosterone	174,186	gonadotropin-releasing_hormone	38,68	testosterone	gonadotropin-releasing hormone	MESH:D013739	2796	Chemical	Gene	feedback|amod|START_ENTITY presence|nmod|feedback Effects|nmod|presence Effects|nmod|system system|amod|END_ENTITY	Effects of melatonin treatment on the gonadotropin-releasing_hormone neuronal system and on gonadotropin secretion in male mink , Mustela vison , in the presence or absence of testosterone feedback .
8184658	0	testosterone	143,155	gonadotropin-releasing_hormone	14,44	testosterone	gonadotropin-releasing hormone	MESH:D013739	25194(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY estimation|nmod|treatment immunoreactivity|dep|estimation immunoreactivity|amod|END_ENTITY	Intracellular gonadotropin-releasing_hormone immunoreactivity in gonadotrophs of intact or castrated male rats : semiquantitative estimation of testosterone and GnRH antagonist treatment .
8495775	0	testosterone	115,127	gonadotropin-releasing_hormone	68,98	testosterone	gonadotropin-releasing hormone	MESH:D013739	2796	Chemical	Gene	supplementation|amod|START_ENTITY antagonist|nmod|supplementation antagonist|amod|END_ENTITY	Sperm motion parameters after suppression of spermatogenesis with a gonadotropin-releasing_hormone antagonist plus testosterone supplementation .
9181521	0	testosterone	113,125	gonadotropin-releasing_hormone	59,89	testosterone	gonadotropin-releasing hormone	MESH:D013739	2796	Chemical	Gene	treatment|amod|START_ENTITY effects|nmod|treatment patterns|dep|effects patterns|nmod|secretion secretion|nmod|patients patients|nmod|deficiency deficiency|amod|END_ENTITY	Pulsatile patterns of melatonin secretion in patients with gonadotropin-releasing_hormone deficiency : effects of testosterone treatment .
10780951	0	testosterone	19,31	growth_hormone	79,93	testosterone	growth hormone	MESH:D013739	81668(Tax:10116)	Chemical	Gene	exposure|acl|START_ENTITY induces|nsubj|exposure induces|dobj|regularity regularity|nmod|process process|amod|END_ENTITY	Single exposure to testosterone in adulthood rapidly induces regularity in the growth_hormone release process .
11472076	0	testosterone	63,75	growth_hormone	4,18	testosterone	growth hormone	MESH:D013739	2688	Chemical	Gene	therapy|amod|START_ENTITY axis|nmod|therapy END_ENTITY|dep|axis	The growth_hormone -LRB- GH -RRB- - insulin-like growth factor axis during testosterone replacement therapy in GH-treated hypopituitary males .
11815725	1	testosterone	110,122	growth_hormone	132,146	testosterone	growth hormone	MESH:D013739	2688	Chemical	Gene	doses|compound|START_ENTITY Effect|nmod|doses Effect|nmod|levels levels|amod|END_ENTITY	Effect of various testosterone doses on growth_hormone levels .
11991768	0	testosterone	48,60	growth_hormone	32,46	testosterone	growth hormone	MESH:D013739	2688	Chemical	Gene	cortisol|amod|START_ENTITY cortisol|amod|END_ENTITY	Effects of ginseng ingestion on growth_hormone , testosterone , cortisol , and insulin-like_growth_factor_1 responses to acute resistance exercise .
12519835	0	testosterone	37,49	growth_hormone	10,24	testosterone	growth hormone	MESH:D013739	2688	Chemical	Gene	replacement|amod|START_ENTITY and/or|dobj|replacement and/or|nsubj|Effect Effect|nmod|END_ENTITY	Effect of growth_hormone -LRB- GH -RRB- and/or testosterone replacement on the prostate in GH-deficient adult patients .
1342592	0	testosterone	11,23	growth_hormone	27,41	testosterone	growth hormone	MESH:D013739	2688	Chemical	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	Effects of testosterone on growth_hormone secretion and somatomedin-C generation in prepubertal growth_hormone deficient male patients .
1417977	0	testosterone	51,63	growth_hormone	14,28	testosterone	growth hormone	MESH:D013739	81668(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY Regulation|nmod|metabolism Regulation|nmod|END_ENTITY	Regulation by growth_hormone and glucocorticoid of testosterone metabolism in long-term cultures of hepatocytes from male and female rats .
14535356	0	testosterone	127,139	growth_hormone	42,56	testosterone	growth hormone	MESH:D013739	81668(Tax:10116)	Chemical	Gene	prolactin|amod|START_ENTITY prolactin|appos|END_ENTITY	Daily profiles of plasma prolactin -LRB- PRL -RRB- , growth_hormone -LRB- GH -RRB- , insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- , luteinizing hormone -LRB- LH -RRB- , testosterone , and melatonin , and of pituitary PRL mRNA and GH mRNA in male Long Evans rats in acute phase of adjuvant_arthritis .
14960025	0	testosterone	13,25	growth_hormone	46,60	testosterone	growth hormone	MESH:D013739	2688	Chemical	Gene	Priming|nmod|START_ENTITY enhances|csubj|Priming enhances|dep|stimulated stimulated|dobj|secretion secretion|amod|END_ENTITY	Priming with testosterone enhances stimulated growth_hormone secretion in boys with delayed_puberty .
15001624	0	testosterone	11,23	growth_hormone	49,63	testosterone	growth hormone	MESH:D013739	2688	Chemical	Gene	relieves|amod|START_ENTITY END_ENTITY|nsubj|relieves	Short-term testosterone supplementation relieves growth_hormone autonegative feedback in men .
15240610	0	testosterone	47,59	growth_hormone	16,30	testosterone	growth hormone	MESH:D013739	2688	Chemical	Gene	treatment|amod|START_ENTITY secretion|nmod|treatment secretion|amod|END_ENTITY	Augmentation of growth_hormone secretion after testosterone treatment in boys with constitutional delay of growth and adolescence : evidence against an increase in hypothalamic secretion of growth_hormone-releasing_hormone .
16332938	0	testosterone	37,49	growth_hormone	15,29	testosterone	growth hormone	MESH:D013739	2688	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|and/or and/or|amod|END_ENTITY	The effects of growth_hormone and/or testosterone in healthy elderly men : a randomized controlled trial .
17029996	0	testosterone	33,45	growth_hormone	11,25	testosterone	growth hormone	MESH:D013739	2688	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|and/or and/or|amod|END_ENTITY	Effects of growth_hormone and/or testosterone on very low density lipoprotein apolipoprotein_B100 kinetics and plasma lipids in healthy elderly men : a randomised controlled trial .
17550998	0	testosterone	10,22	growth_hormone	58,72	testosterone	growth hormone	MESH:D013739	2688	Chemical	Gene	supplementation|compound|START_ENTITY augments|nsubj|supplementation augments|dobj|secretion secretion|compound|END_ENTITY	Long-term testosterone supplementation augments overnight growth_hormone secretion in healthy older men .
18283260	0	testosterone	113,125	growth_hormone	10,24	testosterone	growth hormone	MESH:D013739	2688	Chemical	Gene	concentration|amod|START_ENTITY age|nmod|concentration declines|nmod|age declines|nsubj|releasing releasing|nmod:npmod|END_ENTITY	Ghrelin - growth_hormone releasing and orexigenic hormone in men declines with age , insulin and with decrease in testosterone concentration .
18477661	0	testosterone	37,49	growth_hormone	15,29	testosterone	growth hormone	MESH:D013739	2688	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|END_ENTITY	The effects of growth_hormone and/or testosterone on whole body protein kinetics and skeletal muscle gene expression in healthy elderly men : a randomized controlled trial .
18540253	0	testosterone	3,15	growth_hormone	88,102	testosterone	growth hormone	MESH:D013739	2688	Chemical	Gene	priming|nsubj|START_ENTITY priming|advmod|prior prior|dep|clonidine clonidine|nmod|evaluation evaluation|nmod|status status|amod|END_ENTITY	Is testosterone and estrogen priming prior to clonidine useful in the evaluation of the growth_hormone status of short peripubertal children ?
19576626	0	testosterone	31,43	growth_hormone	84,98	testosterone	growth hormone	MESH:D013739	81668(Tax:10116)	Chemical	Gene	rise|nmod|START_ENTITY responsible|nsubj|rise responsible|nmod|pattern pattern|nmod|secretion secretion|amod|END_ENTITY	Is the early postnatal rise of testosterone responsible for a later male pattern of growth_hormone secretion in pigs ?
19699283	0	testosterone	45,57	growth_hormone	90,104	testosterone	growth hormone	MESH:D013739	81668(Tax:10116)	Chemical	Gene	biosynthesis|compound|START_ENTITY biosynthesis|nmod|END_ENTITY	Nanoparticle-rich diesel exhaust may disrupt testosterone biosynthesis and metabolism via growth_hormone .
20681993	0	testosterone	33,45	growth_hormone	58,72	testosterone	growth hormone	MESH:D013739	2688	Chemical	Gene	START_ENTITY|dep|stimulated stimulated|dobj|secretion secretion|amod|END_ENTITY	The relationship between reduced testosterone , stimulated growth_hormone secretion and increased carotid intima-media thickness in obese men .
2154719	0	testosterone	136,148	growth_hormone	40,54	testosterone	growth hormone	MESH:D013739	81668(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY Loss|dep|role Loss|nmod|effects effects|nmod|clonidine clonidine|nmod|release release|amod|END_ENTITY	Loss of the effects of clonidine on the growth_hormone release and hypotensive action in long-term castrated rats : the possible role of testosterone on alpha-2-adrenergic mechanisms of clonidine .
24691732	0	testosterone	84,96	growth_hormone	20,34	testosterone	growth hormone	MESH:D013739	14599(Tax:10090)	Chemical	Gene	synthesis|amod|START_ENTITY promoting|dobj|synthesis system|acl|promoting induces|dep|system induces|xcomp|END_ENTITY	Osteocalcin induces growth_hormone / insulin-like growth factor-1 system by promoting testosterone synthesis in male mice .
25650168	0	testosterone	24,36	growth_hormone	121,135	testosterone	growth hormone	MESH:D013739	2688	Chemical	Gene	production|amod|START_ENTITY regulation|nmod|production regulation|dep|mediators mediators|nmod|END_ENTITY	Endocrine regulation of testosterone production by Leydig cells in the catfish , Clarias batrachus : Probable mediators of growth_hormone .
2612023	0	testosterone	33,45	growth_hormone	49,63	testosterone	growth hormone	MESH:D013739	2688	Chemical	Gene	Impairment|nmod|START_ENTITY Impairment|nmod|response response|amod|END_ENTITY	Impairment of modulating role of testosterone in growth_hormone response to clonidine in essential_hypertension .
2797945	0	testosterone	76,88	growth_hormone	16,30	testosterone	growth hormone	MESH:D013739	2688	Chemical	Gene	infusion|compound|START_ENTITY augmented|nmod|infusion augmented|nsubjpass|concentration concentration|compound|END_ENTITY	Nocturnal serum growth_hormone concentration is not augmented by short-term testosterone infusion in pubertal boys .
3143542	0	testosterone	179,191	growth_hormone	17,31	testosterone	growth hormone	MESH:D013739	2688	Chemical	Gene	effect|nmod|START_ENTITY gonadotropin-releasing_hormone|nmod|effect gene|amod|gonadotropin-releasing_hormone effect|nmod|gene modulates|dobj|effect modulates|nsubj|END_ENTITY	Endogenous human growth_hormone -LRB- GH -RRB- modulates the effect of gonadotropin-releasing_hormone on pituitary function and the gonadotropin response to the negative feedback effect of testosterone in adult male transgenic_mice bearing human GH gene .
3195533	0	testosterone	14,26	growth_hormone	50,64	testosterone	growth hormone	MESH:D013739	2688	Chemical	Gene	therapy|amod|START_ENTITY therapy|nmod|END_ENTITY	The effect of testosterone therapy on spontaneous growth_hormone secretion in boys with constitutional_delay .
3782098	0	testosterone	45,57	growth_hormone	74,88	testosterone	growth hormone	MESH:D013739	14599(Tax:10090)	Chemical	Gene	regulation|nmod|START_ENTITY hydroxylases|nsubj|regulation hydroxylases|nmod|END_ENTITY	Pretranslational regulation of sex-dependent testosterone hydroxylases by growth_hormone in mouse liver .
3818562	0	testosterone	47,59	growth_hormone	18,32	testosterone	growth hormone	MESH:D013739	81668(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|END_ENTITY	The regulation by growth_hormone of microsomal testosterone 6 beta-hydroxylase in male rat livers .
3921073	0	testosterone	15,27	growth_hormone	58,72	testosterone	growth hormone	MESH:D013739	81668(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|response response|amod|END_ENTITY	The effects of testosterone and estrogen on the pituitary growth_hormone response to growth_hormone-releasing factor .
4042968	0	testosterone	96,108	growth_hormone	14,28	testosterone	growth hormone	MESH:D013739	81668(Tax:10116)	Chemical	Gene	steroid|nmod|START_ENTITY steroid|nsubj|Imprinting Imprinting|nmod|secretion secretion|amod|END_ENTITY	Imprinting of growth_hormone secretion , body growth , and hepatic steroid metabolism by neonatal testosterone .
8772602	0	testosterone	15,27	growth_hormone	82,96	testosterone	growth hormone	MESH:D013739	2688	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|secretion secretion|amod|END_ENTITY	The effects of testosterone and dihydrotestosterone on hypothalamic regulation of growth_hormone secretion .
8882158	0	testosterone	112,124	growth_hormone	12,26	testosterone	growth hormone	MESH:D013739	443329(Tax:9940)	Chemical	Gene	effect|nmod|START_ENTITY Ontogeny|dep|effect Ontogeny|nmod|END_ENTITY	Ontogeny of growth_hormone , insulin-like_growth_factor-I , estradiol and cortisol in the growing lamb : effect of testosterone .
8918979	0	testosterone	15,27	growth_hormone	106,120	testosterone	growth hormone	MESH:D013739	81668(Tax:10116)	Chemical	Gene	replacement|amod|START_ENTITY pattern|nmod|replacement influences|nsubj|pattern influences|nmod|secretion secretion|amod|END_ENTITY	The pattern of testosterone replacement influences the recovery of the stimulatory effect of clonidine on growth_hormone -LRB- GH -RRB- secretion in orchidectomized rats .
9100598	0	testosterone	168,180	growth_hormone	32,46	testosterone	growth hormone	MESH:D013739	2688	Chemical	Gene	exposed|nmod|START_ENTITY exposed|nsubj|Maturation Maturation|nmod|regulation regulation|nmod|secretion secretion|amod|END_ENTITY	Maturation of the regulation of growth_hormone secretion in young males with hypogonadotropic_hypogonadism pharmacologically exposed to progressive increments in serum testosterone .
9703380	0	testosterone	54,66	growth_hormone-releasing_hormone	172,204	testosterone	growth hormone-releasing hormone	MESH:D013739	2691	Chemical	Gene	START_ENTITY|nmod|infusion infusion|amod|END_ENTITY	Unequal impact of age , percentage body fat , and serum testosterone concentrations on the somatotrophic , IGF-I , and IGF-binding protein responses to a three-day intravenous growth_hormone-releasing_hormone pulsatile infusion in men .
15641263	0	testosterone	7,19	hCG	75,78	testosterone	hCG	MESH:D013739	3342	Chemical	Gene	START_ENTITY|nmod|test test|amod|END_ENTITY	Plasma testosterone response at 1st and 4th day after short - and long-term hCG stimulation test .
16725700	0	testosterone	11,23	hCG	57,60	testosterone	hCG	MESH:D013739	3342	Chemical	Gene	START_ENTITY|nmod|boars boars|nmod|administration administration|nmod|END_ENTITY	Peripheral testosterone in boars after administration of hCG , ACTH and testosterone at three ages .
16751622	0	testosterone	52,64	hCG	26,29	testosterone	hCG	MESH:D013739	3342	Chemical	Gene	capacity|amod|START_ENTITY index|nmod|capacity obtain|dobj|index END_ENTITY|xcomp|obtain	Use of a GnRH agonist and hCG to obtain an index of testosterone secretory capacity in the koala -LRB- Phascolarctos_cinereus -RRB- .
22111055	12	testosterone	1571,1583	hCG	1537,1540	testosterone	hCG	MESH:D013739	93659	Chemical	Gene	level|compound|START_ENTITY increased|dobj|level increased|nsubj|treatment treatment|compound|END_ENTITY	The hCG treatment increased the serum testosterone level , penile length , and testicular volume in IHH patients .
2644426	0	testosterone	27,39	hCG	88,91	testosterone	hCG	MESH:D013739	3342	Chemical	Gene	START_ENTITY|nmod|administration administration|nmod|END_ENTITY	Seasonal changes in plasma testosterone concentrations in response to administration of hCG in a desert rodent , the sand rat -LRB- Psammomys obesus -RRB- .
2842265	0	testosterone	151,163	hCG	17,20	testosterone	hCG	MESH:D013739	3342	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Early effects of hCG on human testicular cyclic_AMP content , protein kinase activity , in-vitro progesterone conversion and the serum concentrations of testosterone and oestradiol .
2955060	9	testosterone	1026,1038	hCG	1066,1069	testosterone	hCG	MESH:D013739	3342	Chemical	Gene	START_ENTITY|nmod|medium medium|acl|containing containing|dobj|END_ENTITY	In incubation of small specimens of tumor tissues in oxygenated Krebs bicarbonate buffer , the release of testosterone into the medium containing hCG was twice as high as that into the medium without hCG .
3182393	0	testosterone	66,78	hCG	100,103	testosterone	hCG	MESH:D013739	3342	Chemical	Gene	hyperprolactinemia|nmod|START_ENTITY Effects|nmod|hyperprolactinemia Effects|acl|END_ENTITY	Effects of chronic sulpiride-induced hyperprolactinemia on plasma testosterone and its responses to hCG in normal men .
3425960	0	testosterone	111,123	hCG	91,94	testosterone	hCG	MESH:D013739	93659	Chemical	Gene	secretion|amod|START_ENTITY stimulation|nmod|secretion stimulation|appos|END_ENTITY	Effect of chronic chloroquine treatment on prostaglandin and human chorionic gonadotropin -LRB- hCG -RRB- stimulation of testosterone secretion by the rat testis .
7349418	0	testosterone	8,20	hCG	141,144	testosterone	hCG	MESH:D013739	3342	Chemical	Gene	START_ENTITY|nmod|hypophysectomy hypophysectomy|acl|followed followed|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Plasma testosterone level and structure of the epididymis and accessory organs of the boar -LRB- Sus_scrofa L. -RRB- after hypophysectomy followed by hCG gonadotropin administration -RSB- .
1196544	0	testosterone	46,58	insulin	37,44	testosterone	insulin	MESH:D013739	3630	Chemical	Gene	gonadotropins|amod|START_ENTITY END_ENTITY|appos|gonadotropins	-LSB- Protective effect of some hormones -LRB- insulin , testosterone , human chorionic gonadotropins -RRB- on testicular_damage in alloxan_diabetes in rats -RSB- .
15047639	0	testosterone	45,57	insulin	63,70	testosterone	insulin	MESH:D013739	3630	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	Association of bioavailable , free , and total testosterone with insulin resistance : influence of sex_hormone-binding_globulin and body fat .
16353672	0	testosterone	14,26	insulin	41,48	testosterone	insulin	MESH:D013739	3630	Chemical	Gene	supplement|amod|START_ENTITY supplement|nmod|sensitivity sensitivity|compound|END_ENTITY	The effect of testosterone supplement on insulin sensitivity , glucose effectiveness , and acute insulin response after glucose load in male_type_2 diabetics .
16793958	0	testosterone	56,68	insulin	72,79	testosterone	insulin	MESH:D013739	3630	Chemical	Gene	impact|nmod|START_ENTITY modifies|dobj|impact modifies|nmod|resistance resistance|compound|END_ENTITY	The androgen_receptor CAG repeat modifies the impact of testosterone on insulin resistance in women with polycystic_ovary_syndrome .
17332526	0	testosterone	8,20	insulin	49,56	testosterone	insulin	MESH:D013739	3630	Chemical	Gene	treatment|compound|START_ENTITY induces|nsubj|treatment induces|dobj|resistance resistance|compound|END_ENTITY	Chronic testosterone treatment induces selective insulin resistance in subcutaneous adipocytes of women .
17441374	0	testosterone	167,179	insulin	74,81	testosterone	insulin	MESH:D013739	3630	Chemical	Gene	level|amod|START_ENTITY women|nmod|level correlates|nmod|women correlates|nmod|distribution distribution|nmod|tissue tissue|nmod|END_ENTITY	-LSB- Leptin correlates with distribution of fatty tissue and plasma levels of insulin , testosterone and tumor_necrosis_factor_alpha in perimenopausal women with increased testosterone level and central location of body fat -RSB- .
17954419	0	testosterone	10,22	insulin	26,33	testosterone	insulin	MESH:D013739	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|sensitivity sensitivity|compound|END_ENTITY	Effect of testosterone on insulin sensitivity in men with idiopathic_hypogonadotropic_hypogonadism .
19394003	0	testosterone	42,54	insulin	147,154	testosterone	insulin	MESH:D013739	3630	Chemical	Gene	associated|nmod|START_ENTITY associated|xcomp|resulting resulting|nmod|resistance resistance|compound|END_ENTITY	Smoking is associated with increased free testosterone and fasting insulin levels in women with polycystic_ovary_syndrome , resulting in aggravated insulin resistance .
19661128	0	testosterone	12,24	insulin	58,65	testosterone	insulin	MESH:D013739	3630	Chemical	Gene	associated|nsubjpass|START_ENTITY associated|nmod|resistance resistance|compound|END_ENTITY	Lower serum testosterone is independently associated with insulin resistance in non-diabetic older men : the Health In Men Study .
19846742	0	testosterone	13,25	insulin	74,81	testosterone	insulin	MESH:D013739	3630	Chemical	Gene	concentration|compound|START_ENTITY associated|nsubjpass|concentration associated|nmod|resistance resistance|compound|END_ENTITY	Higher serum testosterone concentration in older women is associated with insulin resistance , metabolic_syndrome , and cardiovascular_disease .
19966179	0	testosterone	46,58	insulin	95,102	testosterone	insulin	MESH:D013739	3630	Chemical	Gene	excess|compound|START_ENTITY excess|nmod|index index|compound|END_ENTITY	Developmental programming : impact of prenatal testosterone excess and postnatal weight_gain on insulin sensitivity index and transfer of traits to offspring of overweight females .
20877139	0	testosterone	40,52	insulin	112,119	testosterone	insulin	MESH:D013739	3630	Chemical	Gene	influence|nmod|START_ENTITY Focusing|nmod|influence Focusing|parataxis|missing missing|nmod|resistance resistance|compound|END_ENTITY	WITHDRAWN : Focusing on the influence of testosterone on leptin and resistin in male hypogonads : missing link in insulin resistance ?
21084769	0	testosterone	41,53	insulin	113,120	testosterone	insulin	MESH:D013739	3630	Chemical	Gene	influence|nmod|START_ENTITY Focusing|nmod|influence Focusing|parataxis|missing missing|nmod|resistance resistance|compound|END_ENTITY	Retraction : Focusing on the influence of testosterone on leptin and resistin in male hypogonads : missing link in insulin resistance ?
22732238	0	testosterone	17,29	insulin	94,101	testosterone	insulin	MESH:D013739	3630	Chemical	Gene	Circulating|dobj|START_ENTITY increases|csubj|Circulating increases|nmod|sensitivity sensitivity|compound|END_ENTITY	Circulating free testosterone in obese men after bariatric surgery increases in parallel with insulin sensitivity .
23525243	0	testosterone	46,58	insulin	69,76	testosterone	insulin	MESH:D013739	105613195	Chemical	Gene	excess|compound|START_ENTITY excess|nmod|sensitivity sensitivity|compound|END_ENTITY	Developmental programming : impact of prenatal testosterone excess on insulin sensitivity , adiposity , and free fatty_acid profile in postpubertal female sheep .
2498378	0	testosterone	56,68	insulin	21,28	testosterone	insulin	MESH:D013739	3630	Chemical	Gene	levels|compound|START_ENTITY reduces|dobj|levels reduces|nsubj|Suppression Suppression|nmod|END_ENTITY	Suppression of serum insulin by diazoxide reduces serum testosterone levels in obese women with polycystic_ovary_syndrome .
26417412	0	testosterone	21,33	insulin	39,46	testosterone	insulin	MESH:D013739	3630	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	Correlation of serum testosterone with insulin resistance in elderly male_type_2_diabetes_mellitus patients with osteoporosis .
3078814	0	testosterone	144,156	insulin	46,53	testosterone	insulin	MESH:D013739	483665(Tax:9615)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|END_ENTITY	On changes in pancreas cytomorphometry , serum insulin and metabolic adjustments induced by long term orchidectomy and substitutive therapy with testosterone in dogs .
8687515	0	testosterone	70,82	insulin	102,109	testosterone	insulin	MESH:D013739	3630	Chemical	Gene	alpha|dobj|START_ENTITY alpha|nmod|reduction reduction|nmod|secretion secretion|compound|END_ENTITY	Decreases in ovarian cytochrome_P450c17 alpha activity and serum free testosterone after reduction of insulin secretion in polycystic_ovary_syndrome .
9421468	0	testosterone	36,48	insulin	60,67	testosterone	insulin	MESH:D013739	3630	Chemical	Gene	results|amod|START_ENTITY results|nmod|resistance resistance|compound|END_ENTITY	Imprinting of female offspring with testosterone results in insulin resistance and changes in body fat distribution at adult age in rats .
14535356	0	testosterone	127,139	insulin-like_growth_factor-1	63,91	testosterone	insulin-like growth factor-1	MESH:D013739	24482(Tax:10116)	Chemical	Gene	prolactin|amod|START_ENTITY prolactin|appos|END_ENTITY	Daily profiles of plasma prolactin -LRB- PRL -RRB- , growth_hormone -LRB- GH -RRB- , insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- , luteinizing hormone -LRB- LH -RRB- , testosterone , and melatonin , and of pituitary PRL mRNA and GH mRNA in male Long Evans rats in acute phase of adjuvant_arthritis .
1315260	0	testosterone	10,22	insulin-like_growth_factor-I	26,54	testosterone	insulin-like growth factor-I	MESH:D013739	24482(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of testosterone on insulin-like_growth_factor-I -LRB- IGF-I -RRB- and IGF-I_receptor gene expression in the hypophysectomized rat .
8971550	0	testosterone	10,22	insulin-like_growth_factor-I	37,65	testosterone	insulin-like growth factor-I	MESH:D013739	3479	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|binding binding|nmod|END_ENTITY	Effect of testosterone on binding of insulin-like_growth_factor-I -LRB- IGF-I -RRB- and IGF-II in growing antlers of fallow deer -LRB- Dama dama -RRB- .
23150680	0	testosterone	49,61	insulin-like_peptide-3	7,29	testosterone	insulin-like peptide-3	MESH:D013739	3640	Chemical	Gene	levels|nmod|START_ENTITY levels|amod|END_ENTITY	Normal insulin-like_peptide-3 levels despite low testosterone in adult males with Prader-Willi_syndrome : variations in Leydig cell function from infancy through adulthood .
16842700	0	testosterone	12,24	insulin_receptor_substrate-1	28,56	testosterone	insulin receptor substrate-1	MESH:D013739	16367(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|amod|END_ENTITY	-LSB- Effects of testosterone on insulin_receptor_substrate-1 and glucose_transporter_4 expression in cells sensitive to insulin -RSB- .
16777918	0	testosterone	10,22	kallikrein	57,67	testosterone	kallikrein	MESH:D013739	9622	Chemical	Gene	administration|amod|START_ENTITY Effect|nmod|administration Effect|nmod|concentrations concentrations|compound|END_ENTITY	Effect of testosterone administration on serum and urine kallikrein concentrations in female-to-male transsexuals .
10076188	0	testosterone	198,210	leptin	93,99	testosterone	leptin	MESH:D013739	3952	Chemical	Gene	effect|nmod|START_ENTITY lack|nmod|effect END_ENTITY|dep|lack	Dihydrotestosterone , stanozolol , androstenedione and dehydroepiandrosterone_sulphate inhibit leptin secretion in female but not in male samples of omental adipose tissue in vitro : lack of effect of testosterone .
10407221	0	testosterone	54,66	leptin	88,94	testosterone	leptin	MESH:D013739	3952	Chemical	Gene	START_ENTITY|nmod|concentration concentration|compound|END_ENTITY	Effects of anabolic-androgenic_steroid use or gonadal testosterone suppression on serum leptin concentration in men .
10468964	0	testosterone	69,81	leptin	11,17	testosterone	leptin	MESH:D013739	698728(Tax:9544)	Chemical	Gene	levels|amod|START_ENTITY circulating|dobj|levels affect|xcomp|circulating affect|nsubj|infusion infusion|compound|END_ENTITY	Short-term leptin infusion does not affect circulating levels of LH , testosterone or cortisol in food-restricted pubertal male rhesus_macaques .
10468969	0	testosterone	63,75	leptin	6,12	testosterone	leptin	MESH:D013739	3952	Chemical	Gene	decreased|dobj|START_ENTITY levels|parataxis|decreased levels|compound|END_ENTITY	Serum leptin levels in healthy ageing men : are decreased serum testosterone and increased adiposity in elderly men the consequence of leptin_deficiency ?
12105281	0	testosterone	87,99	leptin	54,60	testosterone	leptin	MESH:D013739	3952	Chemical	Gene	adjusted|nmod|START_ENTITY levels|acl|adjusted levels|compound|END_ENTITY	A quantitative trait locus on chromosome 22 for serum leptin levels adjusted for serum testosterone .
14709793	0	testosterone	19,31	leptin	42,48	testosterone	leptin	MESH:D013739	25608(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|turnover turnover|compound|END_ENTITY	Modulatory role of testosterone in plasma leptin turnover in rats .
19293441	0	testosterone	48,60	leptin	40,46	testosterone	leptin	MESH:D013739	25608(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Influence Influence|nmod|feeding feeding|nmod|END_ENTITY	Influence of squalene feeding on plasma leptin , testosterone _ blood pressure in rats .
9466130	0	testosterone	71,83	leptin	28,34	testosterone	leptin	MESH:D013739	3952	Chemical	Gene	relationships|nmod|START_ENTITY differences|dep|relationships differences|nmod|END_ENTITY	Gender differences in serum leptin in obese people : relationships with testosterone , body fat distribution and insulin sensitivity .
1090841	0	testosterone	32,44	luteinizing_hormone-releasing_factor	69,105	testosterone	luteinizing hormone-releasing factor	MESH:D013739	153222	Chemical	Gene	response|amod|START_ENTITY response|nmod|END_ENTITY	Daily variations of FSH , LH and testosterone response to intravenous luteinizing_hormone-releasing_factor -LRB- LRF -RRB- in normal men .
2182179	0	testosterone	75,87	luteinizing_hormone-releasing_hormone	27,64	testosterone	luteinizing hormone-releasing hormone	MESH:D013739	613033(Tax:9544)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|levels levels|amod|END_ENTITY	Regulation of hypothalamic luteinizing_hormone-releasing_hormone levels by testosterone and estradiol in male rhesus_monkeys .
22093775	0	testosterone	86,98	luteinizing_hormone-releasing_hormone	125,162	testosterone	luteinizing hormone-releasing hormone	MESH:D013739	2796	Chemical	Gene	suppression|compound|START_ENTITY suppression|acl|followed followed|nmod|agonist agonist|amod|END_ENTITY	New treatment paradigm for prostate_cancer : abarelix initiation therapy for immediate testosterone suppression followed by a luteinizing_hormone-releasing_hormone agonist .
22564197	0	testosterone	11,23	luteinizing_hormone-releasing_hormone	41,78	testosterone	luteinizing hormone-releasing hormone	MESH:D013739	2796	Chemical	Gene	START_ENTITY|nmod|agonists agonists|amod|END_ENTITY	Incomplete testosterone suppression with luteinizing_hormone-releasing_hormone agonists : does it happen and does it matter ?
2695172	0	testosterone	3,15	luteinizing_hormone-releasing_hormone	75,112	testosterone	luteinizing hormone-releasing hormone	MESH:D013739	25194(Tax:10116)	Chemical	Gene	enforce|nsubj|START_ENTITY enforce|dobj|inhibition inhibition|nmod|secretion secretion|amod|END_ENTITY	Do testosterone and estradiol-17 beta enforce inhibition or stimulation of luteinizing_hormone-releasing_hormone secretion ?
2949980	0	testosterone	59,71	luteinizing_hormone-releasing_hormone	83,120	testosterone	luteinizing hormone-releasing hormone	MESH:D013739	2796	Chemical	Gene	START_ENTITY|acl|induced induced|nmod|analogs analogs|amod|END_ENTITY	Cyproterone_acetate lead-in prevents initial rise of serum testosterone induced by luteinizing_hormone-releasing_hormone analogs in the treatment of metastatic carcinoma_of_the_prostate .
3907237	0	testosterone	146,158	luteinizing_hormone-releasing_hormone	36,73	testosterone	luteinizing hormone-releasing hormone	MESH:D013739	25194(Tax:10116)	Chemical	Gene	modulated|xcomp|START_ENTITY modulated|nsubjpass|response response|nmod|END_ENTITY	The luteinizing hormone response to luteinizing_hormone-releasing_hormone , prostaglandin_E2 and naloxone is modulated by divergent sensitivity to testosterone feedback .
7044762	0	testosterone	26,38	luteinizing_hormone-releasing_hormone	55,92	testosterone	luteinizing hormone-releasing hormone	MESH:D013739	25194(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	Discriminative effects of testosterone on hypothalamic luteinizing_hormone-releasing_hormone levels and luteinizing hormone secretion in castrated male rats : analyses of dose and duration characteristics .
9783932	0	testosterone	31,43	luteinizing_hormone-releasing_hormone	58,95	testosterone	luteinizing hormone-releasing hormone	MESH:D013739	2796	Chemical	Gene	START_ENTITY|nmod|agonist agonist|amod|END_ENTITY	Time to normalization of serum testosterone after 3-month luteinizing_hormone-releasing_hormone agonist administered in the neoadjuvant setting : implications for dosing schedule and neoadjuvant study consideration .
26055256	0	testosterone	42,54	neuropeptide_Y	78,92	testosterone	neuropeptide Y	MESH:D013739	4852	Chemical	Gene	START_ENTITY|nmod|administration administration|compound|END_ENTITY	Regulation of feeding behavior and plasma testosterone in response to central neuropeptide_Y administration in a songbird .
1437858	0	testosterone	104,116	ornithine_decarboxylase	28,51	testosterone	ornithine decarboxylase	MESH:D013739	24609(Tax:10116)	Chemical	Gene	organs|amod|START_ENTITY decarboxylase|nmod|organs decarboxylase|nsubj|induction induction|nmod|END_ENTITY	Dose-dependent induction of ornithine_decarboxylase and S-adenosyl-methionine decarboxylase activity by testosterone in the accessory sex organs of male rats .
2082182	0	testosterone	34,46	ornithine_decarboxylase	59,82	testosterone	ornithine decarboxylase	MESH:D013739	24609(Tax:10116)	Chemical	Gene	START_ENTITY|xcomp|decrease decrease|dobj|levels levels|amod|END_ENTITY	Protein synthesis is required for testosterone to decrease ornithine_decarboxylase messenger RNA levels in rat Sertoli cells .
24305501	0	testosterone	27,39	ornithine_decarboxylase	48,71	testosterone	ornithine decarboxylase	MESH:D013739	18263(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|inhibitor inhibitor|amod|END_ENTITY	Combined administration of testosterone plus an ornithine_decarboxylase inhibitor as a selective prostate-sparing anabolic therapy .
7993945	0	testosterone	98,110	ornithine_decarboxylase	25,48	testosterone	ornithine decarboxylase	MESH:D013739	18263(Tax:10090)	Chemical	Gene	influence|nmod|START_ENTITY development|dep|influence development|nmod|END_ENTITY	Postnatal development of ornithine_decarboxylase and polyamines in the mouse kidney : influence of testosterone .
8307774	0	testosterone	110,122	ornithine_decarboxylase	28,51	testosterone	ornithine decarboxylase	MESH:D013739	18263(Tax:10090)	Chemical	Gene	treatment|amod|START_ENTITY expression|nmod|treatment expression|nmod|gene gene|amod|END_ENTITY	Heterogeneous expression of ornithine_decarboxylase gene in the proximal tubule of the mouse kidney following testosterone treatment .
8429279	0	testosterone	89,101	ornithine_decarboxylase	13,36	testosterone	ornithine decarboxylase	MESH:D013739	18263(Tax:10090)	Chemical	Gene	treatment|amod|START_ENTITY kidney|nmod|treatment immunoreactivity|nmod|kidney immunoreactivity|amod|END_ENTITY	Induction of ornithine_decarboxylase immunoreactivity in the male mouse kidney following testosterone treatment : an axial heterogeneity in the proximal tubule .
23886839	0	testosterone	96,108	osteocalcin	6,17	testosterone	osteocalcin	MESH:D013739	632	Chemical	Gene	females|nmod|START_ENTITY adiponectin|nmod|females state|nmod|adiponectin associated|nmod|state associated|nsubjpass|END_ENTITY	Serum osteocalcin is associated with improved metabolic state via adiponectin in females versus testosterone in males .
25788487	0	testosterone	46,58	oxytocin	9,17	testosterone	oxytocin	MESH:D013739	5020	Chemical	Gene	increases|nmod|START_ENTITY increases|nsubj|END_ENTITY	Salivary oxytocin increases concurrently with testosterone and time away from home among returning Tsimane ' hunters .
26703444	0	testosterone	10,22	p53	44,47	testosterone	p53	MESH:D013739	22060(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|regulation regulation|nmod|END_ENTITY	Effect of testosterone on the regulation of p53 and p66Shc during oxidative stress damage in C2C12 cells .
1736034	0	testosterone	18,30	plasminogen_activator_inhibitor-1	52,85	testosterone	plasminogen activator inhibitor-1	MESH:D013739	5054	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of free testosterone on antigen levels of plasminogen_activator_inhibitor-1 in premenopausal women with central_obesity .
117045	0	testosterone	74,86	prolactin	12,21	testosterone	prolactin	MESH:D013739	5617	Chemical	Gene	administration|nmod|START_ENTITY TRH|nmod|administration END_ENTITY|nmod|TRH	Circulating prolactin and its response to TRH following administration of testosterone undecanoate in normal men .
122406	0	testosterone	70,82	prolactin	11,20	testosterone	prolactin	MESH:D013739	5617	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of prolactin and prolactin plus luteinizing hormone on plasma testosterone levels in normal adult men .
12660266	0	testosterone	41,53	prolactin	87,96	testosterone	prolactin	MESH:D013739	5617	Chemical	Gene	implants|amod|START_ENTITY implants|nmod|combination combination|nmod|inhibitor inhibitor|compound|END_ENTITY	An investigation of the effectiveness of testosterone implants in combination with the prolactin inhibitor quinagolide in the suppression of spermatogenesis in men .
159772	0	testosterone	67,79	prolactin	56,65	testosterone	prolactin	MESH:D013739	5617	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|diet diet|nmod|END_ENTITY	Effect of a vegetarian diet and dexamethasone on plasma prolactin , testosterone and dehydroepiandrosterone in men and women .
20795476	0	testosterone	11,23	prolactin	92,101	testosterone	prolactin	MESH:D013739	5617	Chemical	Gene	Effect|nmod|START_ENTITY stimulated|nsubj|Effect stimulated|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Effect of testosterone in Ca2 + mobilization in oocytes and porcine granulose stimulated by prolactin and theophylline -RSB- .
2106098	0	testosterone	21,33	prolactin	67,76	testosterone	prolactin	MESH:D013739	24683(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|control control|nmod|secretion secretion|compound|END_ENTITY	Modulatory effect of testosterone on the serotoninergic control of prolactin secretion in prepubertal rats .
2122770	0	testosterone	55,67	prolactin	32,41	testosterone	prolactin	MESH:D013739	5617	Chemical	Gene	production|amod|START_ENTITY endogenous|nmod|production endogenous|dobj|secretion secretion|compound|END_ENTITY	Effect of modulating endogenous prolactin secretion on testosterone production in the adult male bonnet monkey -LRB- Macaca radiata -RRB- .
2707462	0	testosterone	113,125	prolactin	24,33	testosterone	prolactin	MESH:D013739	5617	Chemical	Gene	therapy|amod|START_ENTITY effect|nmod|therapy secretion|dep|effect secretion|compound|END_ENTITY	Metoclopramide-mediated prolactin secretion in patients with idiopathic_hypogonadotropic_hypogonadism : effect of testosterone therapy .
2708123	0	testosterone	55,67	prolactin	11,20	testosterone	prolactin	MESH:D013739	24683(Tax:10116)	Chemical	Gene	secretion|compound|START_ENTITY luteinizing|dobj|secretion END_ENTITY|acl|luteinizing	Effects of prolactin on luteinizing hormone-stimulated testosterone secretion in isolated perfused rat testis .
3701244	0	testosterone	9,21	prolactin	45,54	testosterone	prolactin	MESH:D013739	24683(Tax:10116)	Chemical	Gene	potentiates|compound|START_ENTITY stimulated|nsubj|potentiates stimulated|dobj|secretion secretion|compound|END_ENTITY	Neonatal testosterone potentiates stimulated prolactin secretion in adult oestrogen-primed rats .
3889211	0	testosterone	55,67	prolactin	17,26	testosterone	prolactin	MESH:D013739	24683(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nmod|effect	Possible role of prolactin in the inhibitory effect of testosterone on the hypothalamic-pituitary-testicular axis in the rat .
606670	0	testosterone	22,34	prolactin	52,61	testosterone	prolactin	MESH:D013739	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Effect of estradiol _ testosterone on the pituitary prolactin levels in developing male _ female rats .
6431047	0	testosterone	14,26	prolactin	30,39	testosterone	prolactin	MESH:D013739	396453(Tax:9031)	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	Inhibition by testosterone of prolactin and growth hormone release from chicken anterior pituitary glands in vitro .
6437791	0	testosterone	22,34	prolactin	5,14	testosterone	prolactin	MESH:D013739	101843376	Chemical	Gene	feedback|amod|START_ENTITY modify|dobj|feedback modify|nsubj|END_ENTITY	Does prolactin modify testosterone feedback in the hamster ?
6437791	1	testosterone	134,146	prolactin	82,91	testosterone	prolactin	MESH:D013739	101843376	Chemical	Gene	sensitivity|amod|START_ENTITY decreases|nmod|sensitivity inhibits|dobj|decreases inhibits|nsubj|Suppression Suppression|nmod|END_ENTITY	Suppression of plasma prolactin inhibits photoperiod-induced decreases in testosterone feedback sensitivity .
6616254	0	testosterone	29,41	prolactin	122,131	testosterone	prolactin	MESH:D013739	24683(Tax:10116)	Chemical	Gene	influences|nmod:poss|START_ENTITY important|nmod|influences cervically|amod|important cervically|acl|stimulated stimulated|dobj|secretion secretion|compound|END_ENTITY	Aromatization : important for testosterone 's developmental influences on the neurocircuits mediating cervically stimulated prolactin secretion in the female rat .
6709643	0	testosterone	64,76	prolactin	14,23	testosterone	prolactin	MESH:D013739	19109(Tax:10090)	Chemical	Gene	doses|nmod|START_ENTITY secretion|nmod|doses secretion|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of prolactin secretion by moderate and high doses of testosterone .
7087660	0	testosterone	17,29	prolactin	55,64	testosterone	prolactin	MESH:D013739	24683(Tax:10116)	Chemical	Gene	administration|amod|START_ENTITY influence|nmod|administration influence|nmod|levels levels|compound|END_ENTITY	The influence of testosterone administration on plasma prolactin levels in the neonatally androgenized -LRB- NA -RRB- female rat .
7359475	0	testosterone	11,23	prolactin	47,56	testosterone	prolactin	MESH:D013739	24683(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of testosterone and oestrogen on serum prolactin in the androgen-insensitive rat .
7439884	1	testosterone	123,135	prolactin	143,152	testosterone	prolactin	MESH:D013739	24683(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of testosterone and/or prolactin .
832635	0	testosterone	60,72	prolactin	25,34	testosterone	prolactin	MESH:D013739	24683(Tax:10116)	Chemical	Gene	administration|amod|START_ENTITY changes|nmod|administration changes|nmod|cells cells|compound|END_ENTITY	Morphological changes in prolactin cells of male rats after testosterone administration .
9109599	0	testosterone	122,134	prolactin	10,19	testosterone	prolactin	MESH:D013739	5617	Chemical	Gene	effects|nmod|START_ENTITY Effect|dep|effects Effect|nmod|END_ENTITY	Effect of prolactin on the attractiveness of male odors to females in meadow voles : independent and additive effects with testosterone .
6329976	0	testosterone	89,101	prolactin_receptor	12,30	testosterone	prolactin receptor	MESH:D013739	24684(Tax:10116)	Chemical	Gene	responsivity|xcomp|START_ENTITY alters|xcomp|responsivity END_ENTITY|parataxis|alters	Rat hepatic prolactin_receptor : pubertal exposure to sex steroids alters responsivity to testosterone .
7830001	0	testosterone	89,101	prolactin_receptor	27,45	testosterone	prolactin receptor	MESH:D013739	24684(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Differential regulation of prolactin_receptor mRNA expression in rat liver and kidney by testosterone and oestradiol .
9394845	0	testosterone	22,34	proliferating_cell_nuclear_antigen	46,80	testosterone	proliferating cell nuclear antigen	MESH:D013739	5111	Chemical	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	Relationship of serum testosterone level with proliferating_cell_nuclear_antigen and nm23 protein in human prostatic_carcinoma tissue .
15893813	0	testosterone	89,101	prostate-specific_antigen	32,57	testosterone	prostate-specific antigen	MESH:D013739	354	Chemical	Gene	level|compound|START_ENTITY associated|nmod|level associated|nsubj|Polymorphism Polymorphism|nmod|region region|nmod|gene gene|amod|END_ENTITY	Polymorphism in ARE-I region of prostate-specific_antigen gene associated with low serum testosterone level and high-grade prostate_cancer .
18279929	9	testosterone	1218,1230	prostate-specific_antigen	1257,1282	testosterone	prostate-specific antigen	MESH:D013739	354	Chemical	Gene	levels|compound|START_ENTITY patients|nmod|levels experienced|nmod|patients experienced|dobj|rise rise|amod|END_ENTITY	Of the patients with greater than castrate testosterone levels , 71 % experienced a prostate-specific_antigen rise .
19215619	0	testosterone	13,25	prostate-specific_antigen	61,86	testosterone	prostate-specific antigen	MESH:D013739	354	Chemical	Gene	therapy|amod|START_ENTITY years|nmod|therapy associated|nsubj|years associated|nmod|END_ENTITY	Two years of testosterone therapy associated with decline in prostate-specific_antigen in a man with untreated prostate_cancer .
19681902	0	testosterone	24,36	prostate-specific_antigen	40,65	testosterone	prostate-specific antigen	MESH:D013739	354	Chemical	Gene	START_ENTITY|nmod|ratio ratio|amod|END_ENTITY	Evaluation of the serum testosterone to prostate-specific_antigen ratio as a predictor of prostate_cancer risk .
19912506	0	testosterone	20,32	prostate-specific_antigen	36,61	testosterone	prostate-specific antigen	MESH:D013739	354	Chemical	Gene	relationship|nmod|START_ENTITY relationship|nmod|END_ENTITY	The relationship of testosterone to prostate-specific_antigen in men with sexual_dysfunction .
23217356	0	testosterone	18,30	prostate-specific_antigen	34,59	testosterone	prostate-specific antigen	MESH:D013739	354	Chemical	Gene	START_ENTITY|nmod|ratio ratio|amod|END_ENTITY	The role of serum testosterone to prostate-specific_antigen ratio as a predictor of prostate_cancer risk .
7541587	0	testosterone	32,44	prostate-specific_antigen	89,114	testosterone	prostate-specific antigen	MESH:D013739	354	Chemical	Gene	variations|nmod|START_ENTITY affect|nsubj|variations affect|dobj|END_ENTITY	Physiologic variations of serum testosterone within the normal range do not affect serum prostate-specific_antigen .
7541588	0	testosterone	107,119	prostate-specific_antigen	30,55	testosterone	prostate-specific antigen	MESH:D013739	354	Chemical	Gene	concentration|compound|START_ENTITY influenced|nmod|concentration influenced|nsubjpass|correlation correlation|nmod|END_ENTITY	The correlation between serum prostate-specific_antigen and prostate_cancer is not influenced by the serum testosterone concentration .
7543173	0	testosterone	20,32	prostate-specific_antigen	48,73	testosterone	prostate-specific antigen	MESH:D013739	354	Chemical	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	Effect of exogenous testosterone replacement on prostate-specific_antigen and prostate-specific_membrane_antigen levels in hypogonadal men .
10759667	0	testosterone	54,66	prostate_specific_antigen	25,50	testosterone	prostate specific antigen	MESH:D013739	354	Chemical	Gene	response|acl|START_ENTITY response|nmod|END_ENTITY	Differential response of prostate_specific_antigen to testosterone surge after luteinizing hormone-releasing hormone analogue in prostate_cancer and benign_prostatic_hyperplasia .
11698338	5	testosterone	808,820	prostate_specific_antigen	850,875	testosterone	prostate specific antigen	MESH:D013739	354	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|nmod|END_ENTITY	Since testosterone stimulates the production of prostate_specific_antigen , we considered that the reactive oxygen species response to testosterone may be linked to prostate_specific_antigen .
11698338	5	testosterone	936,948	prostate_specific_antigen	850,875	testosterone	prostate specific antigen	MESH:D013739	354	Chemical	Gene	response|nmod|START_ENTITY linked|nsubjpass|response considered|ccomp|linked considered|advcl|stimulates stimulates|dobj|production production|nmod|END_ENTITY	Since testosterone stimulates the production of prostate_specific_antigen , we considered that the reactive oxygen species response to testosterone may be linked to prostate_specific_antigen .
12585341	0	testosterone	19,31	prostate_specific_antigen	73,98	testosterone	prostate specific antigen	MESH:D013739	354	Chemical	Gene	treatment|compound|START_ENTITY treatment|nmod|proteins proteins|acl|END_ENTITY	Effect of low-dose testosterone treatment on androgen regulated proteins prostate_specific_antigen and sex_hormone_binding_globulin in short prepubertal boys : lack of initiation of puberty .
21788049	0	testosterone	75,87	prostate_specific_antigen	11,36	testosterone	prostate specific antigen	MESH:D013739	354	Chemical	Gene	therapy|amod|START_ENTITY months|nmod|therapy men|nmod|months END_ENTITY|nmod|men	Changes in prostate_specific_antigen in hypogonadal men after 12 months of testosterone replacement therapy : support for the prostate saturation theory .
8683697	0	testosterone	24,36	prostate_specific_antigen	55,80	testosterone	prostate specific antigen	MESH:D013739	354	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	The effect of exogenous testosterone on total and free prostate_specific_antigen levels in healthy young men .
9334599	0	testosterone	25,37	prostate_specific_antigen	53,78	testosterone	prostate specific antigen	MESH:D013739	354	Chemical	Gene	replacement|compound|START_ENTITY replacement|nmod|END_ENTITY	The effect of parenteral testosterone replacement on prostate_specific_antigen in hypogonadal men with erectile_dysfunction .
9649259	0	testosterone	20,32	prostate_specific_antigen	69,94	testosterone	prostate specific antigen	MESH:D013739	354	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Effect of exogenous testosterone on prostate volume , serum and semen prostate_specific_antigen levels in healthy young men .
2393969	3	testosterone	466,478	rat	493,496	testosterone	hCG	MESH:D013739	93659	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	hCG from the gel-filtration step stimulated testosterone production in rat Leydig cells and had a specific activity of approximately 8000 IU/mg , a value which was higher than those of commercial hCGs .
11078439	0	testosterone	143,155	renin	164,169	testosterone	renin	MESH:D013739	5972	Chemical	Gene	active|amod|START_ENTITY END_ENTITY|amod|active	Plasma endothelin and LH-RH , LH , FSH , prolactin , progesterone , 17alpha-hydroxyprogesterone , estrone , 17beta-estradiol , delta4-androstenedione , testosterone , active renin , angiotensin-II and ANP levels in blood and LH , estrone and 17beta-estradiol and pregnanediol levels in urine of normal cycling women .
2700186	0	testosterone	55,67	renin	30,35	testosterone	renin	MESH:D013739	5972	Chemical	Gene	START_ENTITY|nsubj|changes changes|nmod|activity activity|compound|END_ENTITY	Correlative changes of plasma renin activity and serum testosterone in human internal spermatic vein after single administration of human chorionic gonadotropin .
11214227	0	testosterone	20,32	sex_hormone-binding_globulin	72,100	testosterone	sex hormone-binding globulin	MESH:D013739	6462	Chemical	Gene	assay|compound|START_ENTITY assay|parataxis|related related|nmod|END_ENTITY	The DSL analog free testosterone assay : serum levels are not related to sex_hormone-binding_globulin in normative data throughout childhood and adolescence .
15807883	0	testosterone	107,119	sex_hormone-binding_globulin	16,44	testosterone	sex hormone-binding globulin	MESH:D013739	6462	Chemical	Gene	levels|nmod|START_ENTITY associated|nmod|levels associated|nsubjpass|levels levels|nmod|END_ENTITY	Serum levels of sex_hormone-binding_globulin -LRB- SHBG -RRB- are not associated with lower levels of non-SHBG-bound testosterone in male newborns and healthy adult men .
17961146	0	testosterone	156,168	sex_hormone-binding_globulin	4,32	testosterone	sex hormone-binding globulin	MESH:D013739	6462	Chemical	Gene	receiving|xcomp|START_ENTITY men|acl|receiving END_ENTITY|nmod|men	Low sex_hormone-binding_globulin and testosterone levels in association with erectile_dysfunction among human_immunodeficiency_virus-infected men receiving testosterone and oxandrolone .
18505902	0	testosterone	104,116	sex_hormone-binding_globulin	6,34	testosterone	sex hormone-binding globulin	MESH:D013739	6462	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	Lower sex_hormone-binding_globulin is more strongly associated with metabolic_syndrome than lower total testosterone in older men : the Health in Men Study .
2251223	0	testosterone	13,25	sex_hormone-binding_globulin	69,97	testosterone	sex hormone-binding globulin	MESH:D013739	6462	Chemical	Gene	availability|amod|START_ENTITY Reduction|nmod|availability Reduction|nmod|gland gland|amod|5_alpha-reductase 5_alpha-reductase|nmod|END_ENTITY	Reduction of testosterone availability to 5_alpha-reductase by human sex_hormone-binding_globulin in the rat ventral prostate gland in vivo .
2400756	0	testosterone	60,72	sex_hormone-binding_globulin	14,42	testosterone	sex hormone-binding globulin	MESH:D013739	6462	Chemical	Gene	calculated|dobj|START_ENTITY calculated|nsubj|Testosterone Testosterone|appos|END_ENTITY	Testosterone , sex_hormone-binding_globulin , calculated free testosterone , and oestradiol in male vegans and omnivores .
25777143	0	testosterone	153,165	sex_hormone-binding_globulin	32,60	testosterone	sex hormone-binding globulin	MESH:D013739	6462	Chemical	Gene	measurements|compound|START_ENTITY interpretation|nmod|measurements implications|nmod|interpretation association|dep|implications stronger|nmod|association stronger|nsubj|association association|nmod|obesity obesity|nmod|END_ENTITY	The association of obesity with sex_hormone-binding_globulin is stronger than the association with ageing - implications for the interpretation of total testosterone measurements .
3417844	0	testosterone	24,36	sex_hormone-binding_globulin	66,94	testosterone	sex hormone-binding globulin	MESH:D013739	6462	Chemical	Gene	Differential|nmod|START_ENTITY Differential|nmod|END_ENTITY	Differential binding of testosterone and estradiol to isoforms of sex_hormone-binding_globulin : selective alteration of estradiol binding in cirrhosis .
3695486	0	testosterone	98,110	sex_hormone-binding_globulin	17,45	testosterone	sex hormone-binding globulin	MESH:D013739	6462	Chemical	Gene	non-sex_hormone-binding_globulin-bound|dobj|START_ENTITY non-sex_hormone-binding_globulin-bound|nsubj|Changes Changes|nmod|END_ENTITY	Changes in serum sex_hormone-binding_globulin and in serum non-sex_hormone-binding_globulin-bound testosterone during prepuberty in boys .
4040113	0	testosterone	74,86	sex_hormone-binding_globulin	27,55	testosterone	sex hormone-binding globulin	MESH:D013739	6462	Chemical	Gene	concentrations|compound|START_ENTITY concentrations|amod|END_ENTITY	Daily variations of plasma sex_hormone-binding_globulin binding capacity , testosterone and luteinizing hormone concentrations in healthy rested adult males .
1510947	0	testosterone	163,175	sex_hormone_binding_globulin	98,126	testosterone	sex hormone binding globulin	MESH:D013739	6462	Chemical	Gene	photoaffinity|amod|START_ENTITY derivatives|nmod|photoaffinity using|dobj|derivatives amino_acid|xcomp|using amino_acid|nmod|site site|nmod|END_ENTITY	Characterization of Met-139 as the photolabeled amino_acid residue in the steroid binding site of sex_hormone_binding_globulin using delta 6 derivatives of either testosterone or estradiol as unsubstituted photoaffinity labeling reagents .
15823831	0	testosterone	137,149	sex_hormone_binding_globulin	99,127	testosterone	sex hormone binding globulin	MESH:D013739	6462	Chemical	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Different effects of tibolone and continuous combined estrogen plus progestogen hormone therapy on sex_hormone_binding_globulin and free testosterone levels -- an association with mammographic density .
1637726	0	testosterone	54,66	sex_hormone_binding_globulin	15,43	testosterone	sex hormone binding globulin	MESH:D013739	6462	Chemical	Gene	transport|amod|START_ENTITY effects|nmod|transport effects|nmod|END_ENTITY	The effects of sex_hormone_binding_globulin -LRB- SHBG -RRB- on testosterone transport into the cerebrospinal fluid .
17932133	0	testosterone	174,186	sex_hormone_binding_globulin	48,76	testosterone	sex hormone binding globulin	MESH:D013739	6462	Chemical	Gene	androstenediol|nmod|START_ENTITY influence|nmod|androstenediol Determination|dep|influence Determination|nmod|END_ENTITY	Determination of bioavailable testosterone -LSB- non sex_hormone_binding_globulin -LRB- SHBG -RRB- - bound testosterone -RSB- in a population of healthy French men : influence of androstenediol on testosterone binding to SHBG .
17932133	0	testosterone	90,102	sex_hormone_binding_globulin	48,76	testosterone	sex hormone binding globulin	MESH:D013739	6462	Chemical	Gene	-RSB-|compound|START_ENTITY Determination|dep|-RSB- Determination|nmod|END_ENTITY	Determination of bioavailable testosterone -LSB- non sex_hormone_binding_globulin -LRB- SHBG -RRB- - bound testosterone -RSB- in a population of healthy French men : influence of androstenediol on testosterone binding to SHBG .
19627739	0	testosterone	116,128	sex_hormone_binding_globulin	40,68	testosterone	sex hormone binding globulin	MESH:D013739	6462	Chemical	Gene	-RSB-|amod|START_ENTITY variation|nmod|-RSB- causing|dobj|variation factor|acl|causing factor|nsubj|Variations Variations|nmod|concentration concentration|nmod|END_ENTITY	-LSB- Variations in the concentration of the sex_hormone_binding_globulin is a major factor causing a variation in total testosterone values -RSB- .
2525511	0	testosterone	118,130	sex_hormone_binding_globulin	67,95	testosterone	sex hormone binding globulin	MESH:D013739	6462	Chemical	Gene	levels|compound|START_ENTITY Binding|nmod|levels Binding|xcomp|levonorgestrel levonorgestrel|nmod|END_ENTITY	Binding of levonorgestrel , norethisterone and desogestrel to human sex_hormone_binding_globulin and influence on free testosterone levels .
3641693	0	testosterone	57,69	sex_hormone_binding_globulin	81,109	testosterone	sex hormone binding globulin	MESH:D013739	6462	Chemical	Gene	START_ENTITY|xcomp|binding binding|xcomp|END_ENTITY	A comparison of the effects of danazol and gestrinone on testosterone binding to sex_hormone_binding_globulin in vitro and in vivo .
6681600	0	testosterone	11,23	sex_hormone_binding_globulin	170,198	testosterone	sex hormone binding globulin	MESH:D013739	6462	Chemical	Gene	Binding|nmod|START_ENTITY Binding|acl|END_ENTITY	Binding of testosterone and oestradiol to sex_hormone_binding_globulin , human serum albumin and other plasma proteins : evidence for non-specific binding of oestradiol to sex_hormone_binding_globulin .
6681600	0	testosterone	11,23	sex_hormone_binding_globulin	42,70	testosterone	sex hormone binding globulin	MESH:D013739	6462	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|albumin albumin|amod|END_ENTITY	Binding of testosterone and oestradiol to sex_hormone_binding_globulin , human serum albumin and other plasma proteins : evidence for non-specific binding of oestradiol to sex_hormone_binding_globulin .
7188684	0	testosterone	83,95	sex_hormone_binding_globulin	43,71	testosterone	sex hormone binding globulin	MESH:D013739	6462	Chemical	Gene	Dynamics|nmod|START_ENTITY Dynamics|nmod|capacity capacity|nmod|END_ENTITY	Dynamics of the binding capacity of plasma sex_hormone_binding_globulin -LRB- SHBG -RRB- for testosterone and dihydrotestosterone during puberty .
7192922	0	testosterone	100,112	sex_hormone_binding_globulin	13,41	testosterone	sex hormone binding globulin	MESH:D013739	6462	Chemical	Gene	albumin|xcomp|START_ENTITY albumin|nsubj|Influence Influence|nmod|END_ENTITY	Influence of sex_hormone_binding_globulin and serum albumin on the conversion of androstenedione to testosterone by human erythrocytes .
6537787	0	testosterone	10,22	somatomedin-C	26,39	testosterone	somatomedin-C	MESH:D013739	3479	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|concentrations concentrations|amod|END_ENTITY	Effect of testosterone on somatomedin-C concentrations in prepubertal boys .
4038964	0	testosterone	52,64	somatomedin_C	70,83	testosterone	somatomedin C	MESH:D013739	3479	Chemical	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	Effects of gonadotrophin-induced elevation of serum testosterone upon somatomedin_C levels and serum thymidine activity in children .
7264957	0	testosterone	48,60	thiopurine_methyltransferase	4,32	testosterone	thiopurine methyltransferase	MESH:D013739	690050(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY END_ENTITY|dep|regulation	Rat thiopurine_methyltransferase : regulation by testosterone .
812883	0	testosterone	139,151	thyrotropin-releasing_hormone	90,119	testosterone	thyrotropin-releasing hormone	MESH:D013739	7200	Chemical	Gene	administration|amod|START_ENTITY END_ENTITY|nmod|administration	Klinefelter 's _ syndrome : examination of thyroid function , and the TSH and PRL responses to thyrotropin-releasing_hormone prior to and after testosterone administration .
17534406	0	testosterone	14,26	tissue_plasminogen_activator	38,66	testosterone	tissue plasminogen activator	MESH:D013739	100128998	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Physiological testosterone stimulates tissue_plasminogen_activator and tissue_factor_pathway_inhibitor and inhibits plasminogen_activator_inhibitor_type_1 release in endothelial cells .
10720193	0	testosterone	18,30	transferrin	46,57	testosterone	transferrin	MESH:D013739	477071(Tax:9615)	Chemical	Gene	Changes|nmod|START_ENTITY END_ENTITY|nsubj|Changes	Changes in plasma testosterone and testicular transferrin concentration , testicular histology and semen quality after treatment of testosterone-depot plus PMSG to 3 dogs with asthenozoospermia .
3378204	0	testosterone	10,22	tyrosinase	44,54	testosterone	tyrosinase	MESH:D013739	7299	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of testosterone on imidazole-induced tyrosinase expression in B16 melanoma cell culture .
15582112	0	testosterone_enanthate	44,66	androgen_receptor	71,88	testosterone enanthate	androgen receptor	MESH:C004648	24208(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|compound|END_ENTITY	The effect of intrahippocampal injection of testosterone_enanthate -LRB- an androgen_receptor agonist -RRB- and anisomycin -LRB- protein synthesis inhibitor -RRB- on spatial learning and memory in adult , male rats .
401028	0	testosterone_propionate	10,33	ABP	98,101	testosterone propionate	ABP	MESH:D043343	24775(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of testosterone_propionate on levels of carnitine and testicular androgen_binding_protein -LRB- ABP -RRB- in rat epididymis .
401028	0	testosterone_propionate	10,33	androgen_binding_protein	72,96	testosterone propionate	androgen binding protein	MESH:D043343	24775(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|levels levels|nmod|END_ENTITY	Effect of testosterone_propionate on levels of carnitine and testicular androgen_binding_protein -LRB- ABP -RRB- in rat epididymis .
18461199	0	tetraamine	96,106	III	110,113	tetraamine	III	CHEBI:39166	4514	Chemical	Gene	_|amod|START_ENTITY _|appos|END_ENTITY	A computational study of the electronic structure , bonding , and spectral properties of tripodal tetraamine Co -LRB- III -RRB- _ carbonate complexes .
8907228	0	tetrachlorobiphenyls	50,70	cytochrome_b5	15,28	tetrachlorobiphenyls	cytochrome b5	null	64001(Tax:10116)	Chemical	Gene	metabolism|nmod|START_ENTITY END_ENTITY|nmod|metabolism	Involvement of cytochrome_b5 in the metabolism of tetrachlorobiphenyls catalyzed by CYP2B1 and CYP1A1 .
22939091	0	tetrachloroethene	37,54	III	86,89	tetrachloroethene	III	MESH:D013750	4514	Chemical	Gene	_|amod|START_ENTITY _|appos|END_ENTITY	Enhanced reductive dechlorination of tetrachloroethene during reduction of cobalamin _ -LRB- III -RRB- by nano-mackinawite .
12669308	0	tetrachlorohydroquinone	98,121	CD-1	125,129	tetrachlorohydroquinone	CD-1	CHEBI:17042	111334(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|Mice Mice|compound|END_ENTITY	Skin_tumor-promoting potential and systemic effects of pentachlorophenol and its major metabolite tetrachlorohydroquinone in CD-1 Mice .
24336888	0	tetracyanoborate	42,58	CO2	26,29	tetracyanoborate	CO2	null	717	Chemical	Gene	Structure|nmod|START_ENTITY Structure|nmod|END_ENTITY	Structure and dynamics of CO2 and N2 in a tetracyanoborate based ionic liquid .
7926842	0	tetracycline	13,25	S-adenosyl-L-methionine_hydrolase	102,135	tetracycline	S-adenosyl-L-methionine hydrolase	MESH:D013752	927434(Tax:10759)	Chemical	Gene	START_ENTITY|dobj|expression expression|nmod|END_ENTITY	A novel Tn10 tetracycline regulon system controlling expression of the bacteriophage_T3 gene encoding S-adenosyl-L-methionine_hydrolase .
24321708	0	tetracycline	2,14	Sox9	53,57	tetracycline	Sox9	MESH:D013752	140586(Tax:10116)	Chemical	Gene	system|amod|START_ENTITY system|nmod|END_ENTITY	A tetracycline expression system in combination with Sox9 for cartilage tissue engineering .
4920226	0	tetracycline	21,33	Tor	124,127	tetracycline	Tor	MESH:D013752	6097	Chemical	Gene	trial|nmod|START_ENTITY trial|nmod|END_ENTITY	Comparative trial of tetracycline , chloramphenicol , and trimethoprim-sulphamethoxazole in eradication of Vibrio_cholerae El Tor .
10195880	0	tetracycline	65,77	interleukin-2	24,37	tetracycline	interleukin-2	MESH:D013752	3558	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	In vivo manipulation of interleukin-2 expression by a retroviral tetracycline -LRB- tet -RRB- - regulated system .
2151783	0	tetracycline	10,22	lymphocyte_antigen	26,44	tetracycline	lymphocyte antigen	MESH:D013752	3111	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of tetracycline on lymphocyte_antigen expression .
21420750	0	tetracycline	94,106	tetA	70,74	tetracycline	tetA	MESH:D013752	15152827	Chemical	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Real-time polymerase chain reaction for the quantitative detection of tetA and tetB bacterial tetracycline resistance genes in food .
16131500	0	tetracycline	72,84	urate_oxidase	55,68	tetracycline	urate oxidase	MESH:D013752	114768(Tax:10116)	Chemical	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	Characterization of the degradation of recombinant rat urate_oxidase in tetracycline controlled gene expression cells .
2546831	0	tetradecanoyl_phorbol_acetate	29,58	growth_hormone	76,90	tetradecanoyl phorbol acetate	growth hormone	MESH:D013755	2688	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of pretreatment with tetradecanoyl_phorbol_acetate on regulation of growth_hormone and prolactin secretion from ovine anterior pituitary cells .
3678377	0	tetradecanoylphorbol_acetate	22,50	erythropoietin	73,87	tetradecanoylphorbol acetate	erythropoietin	MESH:D013755	2056	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|production production|compound|END_ENTITY	Inhibitory effects of tetradecanoylphorbol_acetate and diacylglycerol on erythropoietin production in human renal_carcinoma cell cultures .
3085729	0	tetradecanoylphorbol_acetate	14,42	thrombin	133,141	tetradecanoylphorbol acetate	thrombin	MESH:D013755	2147	Chemical	Gene	effect|nmod|START_ENTITY induced|nsubj|effect induced|nmod|END_ENTITY	The effect of tetradecanoylphorbol_acetate on calcium-ion mobilization , protein phosphorylation and cytoskeletal assembly induced by thrombin or arachidonate .
10553013	0	tetradecylthioacetic_acid	81,106	PPARalpha	117,126	tetradecylthioacetic acid	PPARalpha	MESH:C062078	25747(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	Modulation of rat liver apolipoprotein gene expression and serum lipid levels by tetradecylthioacetic_acid -LRB- TTA -RRB- via PPARalpha activation .
16269635	2	tetraethylammonium	833,851	Ang_II	874,880	tetraethylammonium	Ang II	MESH:D019789	24179(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|responses responses|compound|END_ENTITY	We examined the effect of PD123319 -LRB- 10 -LRB- -5 -RRB- mol/L -RRB- and the Ca2 + - activated K + -LRB- BKCa -RRB- channel blocker , tetraethylammonium -LRB- 10 -LRB- -4 -RRB- mol/L -RRB- on the Ang_II responses in the presence of telmisartan -LRB- 10 -LRB- -5 -RRB- mol/L -RRB- .
15160922	0	tetraethylenepentamine	14,36	CD34	95,99	tetraethylenepentamine	CD34	MESH:C034269	947	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	The effect of tetraethylenepentamine , a synthetic copper chelating polyamine , on expression of CD34 and CD38 antigens on normal and leukemic hematopoietic cells .
9458783	0	tetragastrin	20,32	mucin	68,73	tetragastrin	mucin	MESH:D013758	65202(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nsubj|effects	Distinct effects of tetragastrin , histamine , and CCh on rat gastric mucin synthesis and contribution of NO .
17331716	0	tetrahydoquinoxalines	32,53	cholesteryl_ester_transfer_protein	64,98	tetrahydoquinoxalines	cholesteryl ester transfer protein	null	1071	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Tetrazole and ester substituted tetrahydoquinoxalines as potent cholesteryl_ester_transfer_protein inhibitors .
21384413	0	tetrahydro-b-carboline	72,94	PDE5	116,120	tetrahydro-b-carboline	PDE5	null	8654	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Design , synthesis and structure-activity relationship of functionalized tetrahydro-b-carboline derivatives as novel PDE5 inhibitors .
26898814	0	tetrahydro-b-carboline	39,61	sstr3	62,67	tetrahydro-b-carboline	sstr3	null	481272(Tax:9615)	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|amod|END_ENTITY	SAR exploration at the C-3 position of tetrahydro-b-carboline sstr3 antagonists .
17570666	0	tetrahydro-beta-carboline-1-carboxylic_acids	6,50	mitogen_activated_protein_kinase-activated_protein_kinase_2	68,127	tetrahydro-beta-carboline-1-carboxylic acids	mitogen activated protein kinase-activated protein kinase 2	null	9261	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Novel tetrahydro-beta-carboline-1-carboxylic_acids as inhibitors of mitogen_activated_protein_kinase-activated_protein_kinase_2 -LRB- MK-2 -RRB- .
26144345	0	tetrahydro-pyrazolopyridines	17,45	ERK2	63,67	tetrahydro-pyrazolopyridines	ERK2	null	5594	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Ligand efficient tetrahydro-pyrazolopyridines as inhibitors of ERK2 kinase .
19954865	0	tetrahydroacridine	53,71	AChE	14,18	tetrahydroacridine	AChE	null	43	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Synthesis and AChE inhibitory activity of new chiral tetrahydroacridine analogues from terpenic cyclanones .
1538717	0	tetrahydroaminoacridine	15,38	acetylcholinesterase	44,64	tetrahydroaminoacridine	acetylcholinesterase	MESH:D013619	43	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of tetrahydroaminoacridine with acetylcholinesterase and butyrylcholinesterase .
1610407	0	tetrahydroaminoacridine	73,96	acetylcholinesterase	23,43	tetrahydroaminoacridine	acetylcholinesterase	MESH:D013619	43	Chemical	Gene	vitro|nmod|START_ENTITY vitro|dobj|protection protection|nmod|END_ENTITY	In vitro protection of acetylcholinesterase and butyrylcholinesterase by tetrahydroaminoacridine .
2390104	0	tetrahydroaminoacridine	67,90	acetylcholinesterase	32,52	tetrahydroaminoacridine	acetylcholinesterase	MESH:D013619	540446(Tax:9913)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|significance significance|nmod|END_ENTITY	Pharmacological significance of acetylcholinesterase inhibition by tetrahydroaminoacridine .
8951687	0	tetrahydroaminoacridine	91,114	acetylcholinesterase	45,65	tetrahydroaminoacridine	acetylcholinesterase	MESH:D013619	105088569	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	The nature of the inhibition of camel retina acetylcholinesterase -LRB- EC 3.1.1.7 -RRB- activity by tetrahydroaminoacridine .
14646243	0	tetrahydrobiopterin	64,83	GTP_cyclohydrolase_I	14,34	tetrahydrobiopterin	GTP cyclohydrolase I	MESH:C003402	2643	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	cGMP inhibits GTP_cyclohydrolase_I activity and biosynthesis of tetrahydrobiopterin in human umbilical vein endothelial cells .
19286659	0	tetrahydrobiopterin	79,98	GTP_cyclohydrolase_I	0,20	tetrahydrobiopterin	GTP cyclohydrolase I	MESH:C003402	14528(Tax:10090)	Chemical	Gene	levels|compound|START_ENTITY END_ENTITY|nsubj|levels	GTP_cyclohydrolase_I expression , protein , and activity determine intracellular tetrahydrobiopterin levels , independent of GTP_cyclohydrolase_feedback_regulatory_protein expression .
9182249	0	tetrahydrobiopterin	27,46	GTP_cyclohydrolase_I	0,20	tetrahydrobiopterin	GTP cyclohydrolase I	MESH:C003402	2643	Chemical	Gene	gene|dep|START_ENTITY gene|amod|END_ENTITY	GTP_cyclohydrolase_I gene , tetrahydrobiopterin , _ and_tyrosine_hydroxylase gene : their relations to dystonia and parkinsonism .
19207718	0	tetrahydrobiopterin	97,116	Ins2	120,124	tetrahydrobiopterin	Ins2	MESH:C003402	16334(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	High-cholesterol diet augments endothelial_dysfunction via elevated oxidative stress and reduced tetrahydrobiopterin in Ins2 -LRB- Akita -RRB- mice , an autosomal dominant mutant type 1 diabetic model .
25451639	0	tetrahydrobiopterin	106,125	NRF2	129,133	tetrahydrobiopterin	NRF2	MESH:C003402	18024(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	Regulation of iNOS function and cellular redox state by macrophage Gch1 reveals specific requirements for tetrahydrobiopterin in NRF2 activation .
14500751	7	tetrahydrobiopterin	1274,1293	TH	1268,1270	tetrahydrobiopterin	TH	MESH:C003402	7054	Chemical	Gene	species|compound|START_ENTITY END_ENTITY|nmod|species	However , dithiothreitol prevents and reverses these effects on TH of tetrahydrobiopterin and reactive nitrogen species .
10411647	0	tetrahydrobiopterin	27,46	Tyrosine_hydroxylase	0,20	tetrahydrobiopterin	Tyrosine hydroxylase	MESH:C003402	7054	Chemical	Gene	cofactor|compound|START_ENTITY binds|dobj|cofactor binds|nsubj|END_ENTITY	Tyrosine_hydroxylase binds tetrahydrobiopterin cofactor with negative cooperativity , as shown by kinetic analyses and surface plasmon resonance detection .
12009308	0	tetrahydrobiopterin	15,34	cyclosporin_A	48,61	tetrahydrobiopterin	cyclosporin A	MESH:C003402	71991(Tax:10090)	Chemical	Gene	synthesis|compound|START_ENTITY synthesis|nmod|END_ENTITY	Stimulation of tetrahydrobiopterin synthesis by cyclosporin_A in mouse brain microvascular endothelial cells .
11716480	0	tetrahydrobiopterin	15,34	erythropoietin	56,70	tetrahydrobiopterin	erythropoietin	MESH:C003402	24335(Tax:10116)	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|effect effect|nmod|END_ENTITY	Involvement of tetrahydrobiopterin in trophic effect of erythropoietin on PC12 cells .
3875040	0	tetrahydrobiopterin	59,78	interleukin_2	14,27	tetrahydrobiopterin	interleukin 2	MESH:C003402	3558	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|activity activity|amod|END_ENTITY	Modulation of interleukin_2 activity by lymphocyte-derived tetrahydrobiopterin .
1379468	0	tetrahydrobiopterin	68,87	nitric_oxide_synthase	11,32	tetrahydrobiopterin	nitric oxide synthase	MESH:C003402	18125(Tax:10090)	Chemical	Gene	relationship|nmod|START_ENTITY END_ENTITY|dep|relationship	Macrophage nitric_oxide_synthase : relationship between enzyme-bound tetrahydrobiopterin and synthase activity .
10839989	0	tetrahydrobiopterin	38,57	phenylalanine_hydroxylase	73,98	tetrahydrobiopterin	phenylalanine hydroxylase	MESH:C003402	24616(Tax:10116)	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|reductase reductase|amod|END_ENTITY	Contrasting effects of N5-substituted tetrahydrobiopterin derivatives on phenylalanine_hydroxylase , dihydropteridine reductase and nitric_oxide synthase .
15464429	0	tetrahydrobiopterin	60,79	phenylalanine_hydroxylase	10,35	tetrahydrobiopterin	phenylalanine hydroxylase	MESH:C003402	18478(Tax:10090)	Chemical	Gene	supplementation|compound|START_ENTITY enhanced|nmod|supplementation enhanced|nsubjpass|activity activity|compound|END_ENTITY	Wild-type phenylalanine_hydroxylase activity is enhanced by tetrahydrobiopterin supplementation in vivo : an implication for therapeutic basis of tetrahydrobiopterin-responsive phenylalanine_hydroxylase deficiency .
15464429	0	tetrahydrobiopterin	60,79	phenylalanine_hydroxylase	176,201	tetrahydrobiopterin	phenylalanine hydroxylase	MESH:C003402	18478(Tax:10090)	Chemical	Gene	supplementation|compound|START_ENTITY supplementation|dep|implication implication|nmod|basis basis|nmod|deficiency deficiency|compound|END_ENTITY	Wild-type phenylalanine_hydroxylase activity is enhanced by tetrahydrobiopterin supplementation in vivo : an implication for therapeutic basis of tetrahydrobiopterin-responsive phenylalanine_hydroxylase deficiency .
15557004	0	tetrahydrobiopterin	47,66	phenylalanine_hydroxylase	108,133	tetrahydrobiopterin	phenylalanine hydroxylase	MESH:C003402	5053	Chemical	Gene	Correction|nmod|START_ENTITY Correction|nmod|patients patients|nmod|mutations mutations|compound|END_ENTITY	Correction of kinetic and stability defects by tetrahydrobiopterin in phenylketonuria patients with certain phenylalanine_hydroxylase mutations .
16290004	0	tetrahydrobiopterin	107,126	phenylalanine_hydroxylase	23,48	tetrahydrobiopterin	phenylalanine hydroxylase	MESH:C003402	5053	Chemical	Gene	Stimulation|nmod|START_ENTITY Stimulation|nmod|activity activity|compound|END_ENTITY	Stimulation of hepatic phenylalanine_hydroxylase activity but not Pah-mRNA expression upon oral loading of tetrahydrobiopterin in normal mice .
17627389	0	tetrahydrobiopterin	80,99	phenylalanine_hydroxylase	38,63	tetrahydrobiopterin	phenylalanine hydroxylase	MESH:C003402	5053	Chemical	Gene	Mutations|nmod|START_ENTITY Mutations|nmod|domain domain|nmod|END_ENTITY	Mutations in the regulatory domain of phenylalanine_hydroxylase and response to tetrahydrobiopterin .
17884650	0	tetrahydrobiopterin	11,30	phenylalanine_hydroxylase	66,91	tetrahydrobiopterin	phenylalanine hydroxylase	MESH:C003402	5053	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of tetrahydrobiopterin and phenylalanine on in vivo human phenylalanine_hydroxylase by phenylalanine_breath_test .
18482855	0	tetrahydrobiopterin	119,138	phenylalanine_hydroxylase	41,66	tetrahydrobiopterin	phenylalanine hydroxylase	MESH:C003402	5053	Chemical	Gene	newborns|nmod|START_ENTITY activity|nmod|newborns activity|amod|END_ENTITY	Development of a model for assessment of phenylalanine_hydroxylase activity in newborns with phenylketonuria receiving tetrahydrobiopterin : a potential for practical implementation .
19394257	0	tetrahydrobiopterin	19,38	phenylalanine_hydroxylase	109,134	tetrahydrobiopterin	phenylalanine hydroxylase	MESH:C003402	5053	Chemical	Gene	START_ENTITY|dep|genetics genetics|nmod|deficiency deficiency|compound|END_ENTITY	Genotype-predicted tetrahydrobiopterin -LRB- BH4 -RRB- - responsiveness and molecular genetics in Croatian patients with phenylalanine_hydroxylase -LRB- PAH -RRB- deficiency .
20705059	0	tetrahydrobiopterin	18,37	phenylalanine_hydroxylase	143,168	tetrahydrobiopterin	phenylalanine hydroxylase	MESH:C003402	18478(Tax:10090)	Chemical	Gene	pharmacodynamics|compound|START_ENTITY insights|nmod|pharmacodynamics heterozygous|nsubj|insights heterozygous|dobj|deficiency deficiency|compound|END_ENTITY	New insights into tetrahydrobiopterin pharmacodynamics from Pah enu1/2 , a mouse model for compound heterozygous tetrahydrobiopterin-responsive phenylalanine_hydroxylase deficiency .
21147011	0	tetrahydrobiopterin	89,108	phenylalanine_hydroxylase	51,76	tetrahydrobiopterin	phenylalanine hydroxylase	MESH:C003402	5053	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Molecular genetics and impact of residual in vitro phenylalanine_hydroxylase activity on tetrahydrobiopterin responsiveness in Turkish PKU population .
22841515	0	tetrahydrobiopterin	50,69	phenylalanine_hydroxylase	11,36	tetrahydrobiopterin	phenylalanine hydroxylase	MESH:C003402	5053	Chemical	Gene	genotype|nmod|START_ENTITY genotype|amod|END_ENTITY	Utility of phenylalanine_hydroxylase genotype for tetrahydrobiopterin responsiveness classification in patients with phenylketonuria .
2722790	0	tetrahydrobiopterin	94,113	phenylalanine_hydroxylase	127,152	tetrahydrobiopterin	phenylalanine hydroxylase	MESH:C003402	24616(Tax:10116)	Chemical	Gene	oxidation|nmod|START_ENTITY 4a-carbinolamine|nmod|oxidation liver|amod|4a-carbinolamine formation|nmod|liver Evidence|nmod|formation END_ENTITY|nsubj|Evidence	Evidence for the formation of the 4a-carbinolamine during the tyrosine-dependent oxidation of tetrahydrobiopterin by rat liver phenylalanine_hydroxylase .
8323303	0	tetrahydrobiopterin	48,67	phenylalanine_hydroxylase	81,106	tetrahydrobiopterin	phenylalanine hydroxylase	MESH:C003402	24616(Tax:10116)	Chemical	Gene	oxidation|nmod|START_ENTITY Products|nmod|oxidation END_ENTITY|nsubj|Products	Products of the tyrosine-dependent oxidation of tetrahydrobiopterin by rat liver phenylalanine_hydroxylase .
9785468	0	tetrahydrobiopterin	59,78	phenylalanine_hydroxylase	27,52	tetrahydrobiopterin	phenylalanine hydroxylase	MESH:C003402	24616(Tax:10116)	Chemical	Gene	concentrations|compound|START_ENTITY Correlation|nmod|concentrations Correlation|amod|END_ENTITY	Correlation of rat hepatic phenylalanine_hydroxylase , with tetrahydrobiopterin and GTP concentrations .
12820	0	tetrahydrobiopterin	40,59	tyrosine_hydroxylase	63,83	tetrahydrobiopterin	tyrosine hydroxylase	MESH:C003402	280707(Tax:9913)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of stereochemical structures of tetrahydrobiopterin on tyrosine_hydroxylase .
23647001	0	tetrahydrobiopterin	12,31	tyrosine_hydroxylase	86,106	tetrahydrobiopterin	tyrosine hydroxylase	MESH:C003402	7054	Chemical	Gene	role|nmod|START_ENTITY role|nmod|regulation regulation|nmod|level level|amod|END_ENTITY	The role of tetrahydrobiopterin and catecholamines in the developmental regulation of tyrosine_hydroxylase level in the brain .
2565733	0	tetrahydrobiopterin	147,166	tyrosine_hydroxylase	58,78	tetrahydrobiopterin	tyrosine hydroxylase	MESH:C003402	280707(Tax:9913)	Chemical	Gene	analogues|compound|START_ENTITY mapped|nmod|analogues Changes|acl|mapped Changes|nmod|END_ENTITY	Changes in the cofactor binding domain of bovine striatal tyrosine_hydroxylase at physiological pH upon cAMP-dependent phosphorylation mapped with tetrahydrobiopterin analogues .
7915013	0	tetrahydrobiopterin	14,33	tyrosine_hydroxylase	68,88	tetrahydrobiopterin	tyrosine hydroxylase	MESH:C003402	25085(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	The effect of tetrahydrobiopterin on the in situ phosphorylation of tyrosine_hydroxylase in rat striatal synaptosomes .
1445887	0	tetrahydrochrysenes	15,34	estrogen_receptor	90,107	tetrahydrochrysenes	estrogen receptor	null	2099	Chemical	Gene	START_ENTITY|appos|ligands ligands|nmod|END_ENTITY	Donor-acceptor tetrahydrochrysenes , inherently fluorescent , high-affinity ligands for the estrogen_receptor : binding and fluorescence characteristics and fluorometric assay of receptor .
16386902	0	tetrahydrodibenzazocines	36,60	17beta-hydroxysteroid_dehydrogenase_type_3	78,120	tetrahydrodibenzazocines	17beta-hydroxysteroid dehydrogenase type 3	null	3293	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Identification of a novel series of tetrahydrodibenzazocines as inhibitors of 17beta-hydroxysteroid_dehydrogenase_type_3 .
23058883	0	tetrahydroimidazopyridine	101,126	O-GlcNAcase	70,81	tetrahydroimidazopyridine	O-GlcNAcase	null	10724	Chemical	Gene	based|nmod|START_ENTITY inhibitor|acl|based inhibitor|amod|END_ENTITY	Elevation of cellular O-GlcNAcylation level by a potent and selective O-GlcNAcase inhibitor based on tetrahydroimidazopyridine scaffold .
20655213	0	tetrahydroisoquinoline	13,35	ICAM-1	95,101	tetrahydroisoquinoline	ICAM-1	null	15894(Tax:10090)	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|compound|END_ENTITY	Discovery of tetrahydroisoquinoline -LRB- THIQ -RRB- derivatives as potent and orally bioavailable LFA-1 / ICAM-1 antagonists .
20655213	0	tetrahydroisoquinoline	13,35	LFA-1	89,94	tetrahydroisoquinoline	LFA-1	null	16408(Tax:10090)	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|compound|END_ENTITY	Discovery of tetrahydroisoquinoline -LRB- THIQ -RRB- derivatives as potent and orally bioavailable LFA-1 / ICAM-1 antagonists .
26320621	0	tetrahydroisoquinoline	53,75	PDE4	101,105	tetrahydroisoquinoline	PDE4	null	5141	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Design , synthesis and biological evaluation of novel tetrahydroisoquinoline derivatives as potential PDE4 inhibitors .
10400340	0	tetrahydroisoquinoline	100,122	phenylethanolamine_N-methyltransferase	145,183	tetrahydroisoquinoline	phenylethanolamine N-methyltransferase	null	5409	Chemical	Gene	START_ENTITY|nmod|site site|nmod|END_ENTITY	1,3-Dimethyl-7-substituted-1 ,2,3,4 - tetrahydroisoquinolines as probes for the binding orientation of tetrahydroisoquinoline at the active site of phenylethanolamine_N-methyltransferase .
18634870	0	tetrahydroisoquinoline_alkaloid	126,157	iNOS	73,77	tetrahydroisoquinoline alkaloid	iNOS	null	18126(Tax:10090)	Chemical	Gene	involved|nmod|START_ENTITY involved|nmod|inhibition inhibition|nmod|END_ENTITY	HO-1 and JAK-2 / STAT-1 signals are involved in preferential inhibition of iNOS over COX-2 gene expression by newly synthesized tetrahydroisoquinoline_alkaloid , CKD712 , in cells activated with lipopolysacchride .
2917150	0	tetrahydrolipstatin	11,30	lipase	34,40	tetrahydrolipstatin	lipase	MESH:C055122	291437(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effects of tetrahydrolipstatin , a lipase inhibitor , on absorption of fat from the intestine of the rat .
16478001	0	tetrahydronaphthalen	42,62	beta2-adrenoceptor	74,92	tetrahydronaphthalen	beta2-adrenoceptor	null	154	Chemical	Gene	agonist|amod|START_ENTITY agonist|amod|END_ENTITY	Cardiovascular effects of KUR-1246 , a new tetrahydronaphthalen derivative beta2-adrenoceptor agonist and a selective uterine relaxant .
26804230	0	tetrahydronaphthalene	16,37	Raf	52,55	tetrahydronaphthalene	Raf	null	22882	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Optimization of tetrahydronaphthalene inhibitors of Raf with selectivity over hERG .
15246775	2	tetrahydrooxazin-2-ones	86,109	5alpha-reductase	149,165	tetrahydrooxazin-2-ones	5alpha-reductase	null	6715	Chemical	Gene	synthesis|amod|START_ENTITY synthesis|nmod|END_ENTITY	Stereoselective synthesis of some steroidal tetrahydrooxazin-2-ones , as novel presumed inhibitors of human 5alpha-reductase .
2713086	0	tetrahydropapaveroline	15,37	dopa-decarboxylase	57,75	tetrahydropapaveroline	dopa-decarboxylase	MESH:D013765	24311(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Interaction of tetrahydropapaveroline with inhibition of dopa-decarboxylase by Ro_4-4602 in brain : effects on alcohol drinking in the rat .
16527408	0	tetrahydropteridines	64,84	sepiapterin_reductase	19,40	tetrahydropteridines	sepiapterin reductase	CHEBI:30436	8627440(Tax:352472)	Chemical	Gene	biosynthesis|nmod|START_ENTITY role|nmod|biosynthesis role|nmod|END_ENTITY	Functional role of sepiapterin_reductase in the biosynthesis of tetrahydropteridines in Dictyostelium_discoideum_Ax2 .
15555584	0	tetrahydropteridines	28,48	tyrosinase	14,24	tetrahydropteridines	tyrosinase	CHEBI:30436	7299	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of tyrosinase by tetrahydropteridines and H2O2 .
17847704	0	tetrahydropteridines	10,30	tyrosinase	82,92	tetrahydropteridines	tyrosinase	CHEBI:30436	7299	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of tetrahydropteridines on the monophenolase and diphenolase activities of tyrosinase .
20460701	0	tetrahydropterines	11,29	tyrosinase	73,83	tetrahydropterines	tyrosinase	null	7299	Chemical	Gene	Effects|nmod|START_ENTITY catalyzed|nsubj|Effects catalyzed|nmod|END_ENTITY	Effects of tetrahydropterines on the generation of quinones catalyzed by tyrosinase .
21299451	0	tetrahydropterines	52,70	tyrosinase	24,34	tetrahydropterines	tyrosinase	null	7299	Chemical	Gene	inactivation|nmod|START_ENTITY inactivation|nmod|END_ENTITY	Suicide inactivation of tyrosinase in its action on tetrahydropterines .
15903319	0	tetrahydropyran	15,30	NK1_receptor	31,43	tetrahydropyran	NK1 receptor	CHEBI:46941	6869	Chemical	Gene	antagonist|amod|START_ENTITY antagonist|amod|END_ENTITY	Synthesis of a tetrahydropyran NK1_receptor antagonist via asymmetric conjugate addition .
23972441	0	tetrahydropyran	6,21	dipeptidyl_peptidase_IV	33,56	tetrahydropyran	dipeptidyl peptidase IV	CHEBI:46941	1803	Chemical	Gene	analogs|compound|START_ENTITY analogs|nmod|inhibitors inhibitors|amod|END_ENTITY	Novel tetrahydropyran analogs as dipeptidyl_peptidase_IV inhibitors : Profile of clinical candidate -LRB- 2R ,3 S ,5 R -RRB- -2 - -LRB- 2,5-difluorophenyl -RRB- -5 - -LRB- 4,6-dihydropyrrolo -LSB- 3,4-c -RSB- pyrazol-5 - -LRB- 1H -RRB- - yl -RRB- tetrahydro-2H-pyran-3-amine -LRB- 23 -RRB- -LSB- corrected -RSB- .
2344359	0	tetrahydropyridines	62,81	monoamine_oxidases_A_and_B	32,58	tetrahydropyridines	monoamine oxidases A and B	CHEBI:26921	4128;4129	Chemical	Gene	inactivation|nmod|START_ENTITY inactivation|nmod|END_ENTITY	Mechanism-based inactivation of monoamine_oxidases_A_and_B by tetrahydropyridines and dihydropyridines .
22543028	0	tetrahydroquinolines	28,48	CETP	64,68	tetrahydroquinolines	CETP	null	1071	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	Design and synthesis of new tetrahydroquinolines derivatives as CETP inhibitors .
8289189	0	tetrahydrostilbazoles	15,36	monoamine_oxidase_A_and_B	42,67	tetrahydrostilbazoles	monoamine oxidase A and B	null	4128;4129	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of tetrahydrostilbazoles with monoamine_oxidase_A_and_B .
1961042	0	tetrahydrouridine	77,94	cytidine_deaminase	112,130	tetrahydrouridine	cytidine deaminase	MESH:D013767	978	Chemical	Gene	START_ENTITY|dep|inhibitor inhibitor|nmod|END_ENTITY	Therapy of refractory/relapsed acute_leukemia with cytosine_arabinoside plus tetrahydrouridine -LRB- an inhibitor of cytidine_deaminase -RRB- -- a pilot study .
791944	0	tetraiodofluorescein	15,35	hexokinase	47,57	tetraiodofluorescein	hexokinase	MESH:D005452	851167(Tax:4932)	Chemical	Gene	Interaction|nmod|START_ENTITY END_ENTITY|nsubj|Interaction	Interaction of tetraiodofluorescein with yeast hexokinase .
25489419	0	tetramethoxystilbene	66,86	annexin_a5	8,18	tetramethoxystilbene	annexin a5	null	308	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Role Role|nmod|END_ENTITY	Role of annexin_a5 on mitochondria-dependent apoptosis induced by tetramethoxystilbene in human breast_cancer cells .
19463925	0	tetramethoxystilbene	50,70	cytochrome_P450_1B1	27,46	tetramethoxystilbene	cytochrome P450 1B1	null	1545	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Potent inhibition of human cytochrome_P450_1B1 by tetramethoxystilbene .
9208604	0	tetramethyl_pyrazine	11,31	endothelin-1	72,84	tetramethyl pyrazine	endothelin-1	MESH:C017953	403424(Tax:9615)	Chemical	Gene	Effect|nmod|START_ENTITY induced|nsubj|Effect induced|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Effect of tetramethyl_pyrazine on coronary vasoconstriction induced by endothelin-1 in dogs -RSB- .
25039149	0	tetramethylpyrazine	11,30	CTGF	39,43	tetramethylpyrazine	CTGF	MESH:C017953	64032(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	-LSB- Effect of tetramethylpyrazine and rat CTGF miRNA plasmids on connective_tissue_growth_factor , transforming growth factor-beta in high glucose stimulated hepatic stellate cells -RSB- .
26810525	0	tetramethylpyrazine	64,83	Heme_oxygenase-1	0,16	tetramethylpyrazine	Heme oxygenase-1	MESH:C017953	24451(Tax:10116)	Chemical	Gene	contributes|nmod|START_ENTITY contributes|nsubj|dependant dependant|amod|END_ENTITY	Heme_oxygenase-1 dependant pathway contributes to protection by tetramethylpyrazine against chronic hypoxic_injury_on_medulla_oblongata in rats .
19956884	0	tetramethylpyrazine	14,33	P-gp	37,41	tetramethylpyrazine	P-gp	MESH:C017953	283871	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of tetramethylpyrazine on P-gp , MRP2 , MRP3 and MRP5 in multidrug resistant human hepatocellular_carcinoma cells .
19382458	0	tetramethylpyrazine	11,30	Smad7	48,53	tetramethylpyrazine	Smad7	MESH:C017953	81516(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of tetramethylpyrazine on expression of Smad7 and SnoN in rats with UUO -RSB- .
16026512	0	tetramethylpyrazine	62,81	endothelin-1	36,48	tetramethylpyrazine	endothelin-1	MESH:C017953	1906	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|secretion secretion|amod|END_ENTITY	Inhibition of cyclic strain-induced endothelin-1 secretion by tetramethylpyrazine .
9595511	0	tetramethylpyrazine	11,30	endothelin-1	62,74	tetramethylpyrazine	endothelin-1	MESH:C017953	403424(Tax:9615)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|amod|END_ENTITY	Effects of tetramethylpyrazine , a Chinese medicine , on plasma endothelin-1 levels during acute pulmonary_hypoxia in anesthetized dogs .
20669672	0	tetramethylpyrazine	12,31	fractalkine	35,46	tetramethylpyrazine	fractalkine	MESH:C017953	6376	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	-LSB- Effects of tetramethylpyrazine on fractalkine and tumor_necrosis_factor-alpha expression in patients with chronic_pulmonary_heart_disease -RSB- .
23117466	0	tetramethylpyrazine	11,30	macrophage_migration_inhibitory_factor	52,90	tetramethylpyrazine	macrophage migration inhibitory factor	MESH:C017953	103694877	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of tetramethylpyrazine on the expression of macrophage_migration_inhibitory_factor in acute spinal_cord_injury in rats -RSB- .
9812653	0	tetramethylpyrazine	79,98	motilin	32,39	tetramethylpyrazine	motilin	MESH:C017953	100126231(Tax:10116)	Chemical	Gene	characteristics|nmod|START_ENTITY characteristics|amod|END_ENTITY	-LSB- Effect of sijunzi decoction on motilin and pharmacokinetic characteristics of tetramethylpyrazine in rat model of spleen_deficiency_syndrome -RSB- .
15830098	0	tetramethylpyrazine	11,30	nNOS	81,85	tetramethylpyrazine	nNOS	MESH:C017953	24598(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of tetramethylpyrazine on the responses of respiration and expression of nNOS in brainstem to hypoxia in rats -RSB- .
17165586	0	tetramethylpyrazine	12,31	vascular_endothelial_growth_factor	49,83	tetramethylpyrazine	vascular endothelial growth factor	MESH:C017953	83785(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of tetramethylpyrazine on expression of vascular_endothelial_growth_factor and hypoxia-induced factor-1alpha by rat peritoneal macrophages -RSB- .
20209919	0	tetramethylpyrazine	17,36	vascular_endothelial_growth_factor	54,88	tetramethylpyrazine	vascular endothelial growth factor	MESH:C017953	83785(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Relationship of tetramethylpyrazine on expression of vascular_endothelial_growth_factor and development of adjuvant-induced_arthritis in rats -RSB- .
7549507	0	tetrandrine	25,36	CD23	44,48	tetrandrine	CD23	MESH:C009438	2208	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|compound|END_ENTITY	The modulatory effect of tetrandrine on the CD23 , CD25 and HLA-DR expression and cytokine production in different groups of asthmatic patients .
8886484	0	tetrandrine	11,22	Ca2	91,94	tetrandrine	Ca2	MESH:C009438	760	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of tetrandrine and closely related bis-benzylisoquinoline derivatives on cytosolic Ca2 + in human leukaemic HL-60 cells : a structure-activity relationship study .
12733343	0	tetrandrine	11,22	bFGF	40,44	tetrandrine	bFGF	MESH:C009438	54250(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of tetrandrine on expression of bFGF in lung tissue of rat with chronic hypoxic pulmonary_hypertension -RSB- .
22366014	0	tetrandrine	11,22	bax	26,29	tetrandrine	bax	MESH:C009438	581	Chemical	Gene	START_ENTITY|nmod|expressions expressions|amod|END_ENTITY	-LSB- Effect of tetrandrine on bax , bcl-2 and TGF-b2 mRNA expressions in cultured human Tenon 's capsule fibroblasts -RSB- .
10072926	0	tetrandrine	10,21	c-fos	40,45	tetrandrine	c-fos	MESH:C009438	314322(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of tetrandrine on proto-oncogene c-fos expression in rat cerebrum .
1310515	0	tetrandrine	23,34	interleukin-1_and_tumor_necrosis_factor	93,132	tetrandrine	interleukin-1 and tumor necrosis factor	MESH:C009438	3552;7124	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Comparative effects of tetrandrine and berbamine on production of the inflammatory cytokines interleukin-1_and_tumor_necrosis_factor .
15604277	8	tetrandrine	1223,1234	p53	1263,1266	tetrandrine	p53	MESH:C009438	7157	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Third , tetrandrine increases the expression of p53 and p21 -LRB- Cip1 -RRB- in wild-type p53 HCT116 cells .
9812743	0	tetrandrine	11,22	platelet-activating_factor	53,79	tetrandrine	platelet-activating factor	MESH:C009438	300795(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|release release|amod|END_ENTITY	Effects of tetrandrine , Fura_2-AM , and Bay_k_8644 on platelet-activating_factor release from rat peritoneal macrophages stimulated by lipopolysaccharides .
6487639	0	tetranitromethane	65,82	cytochrome_P-450scc	40,59	tetranitromethane	cytochrome P-450scc	MESH:D013774	1583	Chemical	Gene	modification|nmod|START_ENTITY modification|nmod|END_ENTITY	Chemical modification of adrenocortical cytochrome_P-450scc with tetranitromethane .
7066412	0	tetranitromethane	37,54	transcortin	22,33	tetranitromethane	transcortin	MESH:D013774	866	Chemical	Gene	Modification|nmod|START_ENTITY Modification|nmod|END_ENTITY	Modification of human transcortin by tetranitromethane .
7030734	0	tetranitromethane	35,52	tryptophanase	16,29	tetranitromethane	tryptophanase	MESH:D013774	6999	Chemical	Gene	Modification|nmod|START_ENTITY Modification|nmod|END_ENTITY	Modification of tryptophanase with tetranitromethane .
25699138	0	tetrapeptides	24,37	melanocortin-3_receptor	81,104	tetrapeptides	melanocortin-3 receptor	CHEBI:48030	17201(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	Melanocortin antagonist tetrapeptides with minimal agonist activity at the mouse melanocortin-3_receptor .
19722701	0	tetraphenylphosphonium	79,101	P-glycoprotein	12,26	tetraphenylphosphonium	P-glycoprotein	MESH:C013289	67078(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of P-glycoprotein in intestinal transport versus the BBB transport of tetraphenylphosphonium .
23964451	0	tetrasaccharide	84,99	salivary_alpha-amylase	28,50	tetrasaccharide	salivary alpha-amylase	CHEBI:50126	276	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Kinetic inhibition of human salivary_alpha-amylase by a novel cellobiose-containing tetrasaccharide .
19039062	0	tetrasodium	48,59	TLR4	63,67	tetrasodium	TLR4	null	7099	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Continuous pharmacodynamic activity of eritoran tetrasodium , a TLR4 antagonist , during intermittent intravenous infusion into normal volunteers .
20220101	0	tetraspanin	12,23	Notch	43,48	tetraspanin	Notch	null	176282(Tax:6239)	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|END_ENTITY	A conserved tetraspanin subfamily promotes Notch signaling in Caenorhabditis_elegans and in human cells .
2867641	0	tetrazolium	107,118	glucose_6-phosphate_dehydrogenase	132,165	tetrazolium	glucose 6-phosphate dehydrogenase	null	2539	Chemical	Gene	reaction|compound|START_ENTITY reaction|nmod|END_ENTITY	Characterization of epithelial cell islets in primary monolayer cultures of human breast_carcinomas by the tetrazolium reaction for glucose_6-phosphate_dehydrogenase .
9208175	0	tetrols	41,48	syn	62,65	tetrols	syn	null	23336	Chemical	Gene	START_ENTITY|acl|derived derived|nmod|END_ENTITY	Conformational studies of stereoisomeric tetrols derived from syn - and anti-dibenzo -LSB- a , l -RSB- pyrene_diol_epoxides .
15339503	0	tetromethylpyrazine	11,30	vascular_endothelial_growth_factor	67,101	tetromethylpyrazine	vascular endothelial growth factor	null	83785(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of tetromethylpyrazine and aminoguanidine on expression of vascular_endothelial_growth_factor in kidney of diabetic rats -RSB- .
9042212	0	thaliblastine	43,56	Pgp	29,32	thaliblastine	Pgp	MESH:C073328	5243	Chemical	Gene	START_ENTITY|nsubj|interactions interactions|nmod|inhibitor inhibitor|compound|END_ENTITY	Differential interactions of Pgp inhibitor thaliblastine with adriamycin , etoposide , taxol and anthrapyrazole_CI941 in sensitive and multidrug-resistant human MCF-7 breast_cancer cells .
19954599	0	thalidomide	12,23	Annexin_II	27,37	thalidomide	Annexin II	MESH:D013792	302	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Effects of thalidomide on Annexin_II gene regulation -RSB- .
11985351	0	thalidomide	13,24	Bcl2	28,32	thalidomide	Bcl2	MESH:D013792	596	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Influence of thalidomide on Bcl2 expression and proangiogenic cytokine levels in short-term culture of peripheral blood and bone marrow mononuclear cells of multiple myeloma patients .
18549624	0	thalidomide	12,23	CD4	27,30	thalidomide	CD4	MESH:D013792	920	Chemical	Gene	START_ENTITY|nmod|CD25 CD25|compound|END_ENTITY	-LSB- Effects of thalidomide on CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- T regulatory cells in patients with multiple_myeloma -RSB- .
21077744	0	thalidomide	34,45	DEPTOR	0,6	thalidomide	DEPTOR	MESH:D013792	64798	Chemical	Gene	START_ENTITY|nsubj|expression expression|amod|END_ENTITY	DEPTOR expression and response to thalidomide : toward a new therapeutic target in multiple myeloma ?
7635184	0	thalidomide	5,16	IL-2	24,28	thalidomide	IL-2	MESH:D013792	3558	Chemical	Gene	affect|nsubj|START_ENTITY affect|dobj|response response|compound|END_ENTITY	Does thalidomide affect IL-2 response and production ?
11367517	0	thalidomide	23,34	NF-kappa_B	81,91	thalidomide	NF-kappa B	MESH:D013792	4790	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nsubj|effect	Differential effect of thalidomide and dexamethasone on the transcription factor NF-kappa_B .
21215621	0	thalidomide	51,62	TNF-a	76,81	thalidomide	TNF-a	MESH:D013792	7124	Chemical	Gene	evaluation|nmod|START_ENTITY analogues|nsubj|evaluation analogues|nmod|inhibitors inhibitors|compound|END_ENTITY	Design , synthesis and biological evaluation of new thalidomide analogues as TNF-a and IL-6 production inhibitors .
10384139	0	thalidomide	82,93	TNF-alpha	134,143	thalidomide	TNF-alpha	MESH:D013792	7124	Chemical	Gene	analogues|amod|START_ENTITY classes|nmod|analogues classes|acl:relcl|inhibitors inhibitors|nmod|END_ENTITY	Differential cytokine modulation and T cell activation by two distinct classes of thalidomide analogues that are potent inhibitors of TNF-alpha .
10499831	0	thalidomide	39,50	TNF-alpha	14,23	thalidomide	TNF-alpha	MESH:D013792	7124	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|synthesis synthesis|amod|END_ENTITY	Inhibition of TNF-alpha synthesis with thalidomide for prevention of acute exacerbations and altering the natural history of multiple_sclerosis .
10606973	0	thalidomide	4,15	TNF-alpha	82,91	thalidomide	TNF-alpha	MESH:D013792	7124	Chemical	Gene	CC-3052|amod|START_ENTITY inhibits|nsubj|CC-3052 inhibits|ccomp|necrosis necrosis|dobj|expression expression|appos|END_ENTITY	The thalidomide analogue CC-3052 inhibits HIV-1 and tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- expression in acutely and chronically infected cells in vitro .
10850856	0	thalidomide	80,91	TNF-alpha	32,41	thalidomide	TNF-alpha	MESH:D013792	24835(Tax:10116)	Chemical	Gene	lung|nmod|START_ENTITY Modulation|nmod|lung Modulation|nmod|expression expression|amod|END_ENTITY	Modulation of hyperoxia-induced TNF-alpha expression in the newborn rat lung by thalidomide and dexamethasone .
14613324	0	thalidomide	47,58	TNF-alpha	73,82	thalidomide	TNF-alpha	MESH:D013792	7124	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Thiothalidomides : novel isosteric analogues of thalidomide with enhanced TNF-alpha inhibitory activity .
15683845	0	thalidomide	27,38	TNF-alpha	64,73	thalidomide	TNF-alpha	MESH:D013792	24835(Tax:10116)	Chemical	Gene	analogue|compound|START_ENTITY analogue|acl:relcl|modulates modulates|dobj|END_ENTITY	LASSBio-468 : a new achiral thalidomide analogue which modulates TNF-alpha and NO production and inhibits endotoxic_shock and arthritis in an animal model .
16877307	0	thalidomide	50,61	TNF-alpha	102,111	thalidomide	TNF-alpha	MESH:D013792	21926(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|formulation formulation|nmod|suppression suppression|nmod|END_ENTITY	Preparation and in vitro analysis of microcapsule thalidomide formulation for targeted suppression of TNF-alpha .
16997792	0	thalidomide	10,21	TNF-alpha	43,52	thalidomide	TNF-alpha	MESH:D013792	7124	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|m-RNA m-RNA|amod|END_ENTITY	Effect of thalidomide on the expression of TNF-alpha m-RNA and synthesis of TNF-alpha in cells from leprosy patients with reversal reaction .
16997792	0	thalidomide	10,21	TNF-alpha	76,85	thalidomide	TNF-alpha	MESH:D013792	7124	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of thalidomide on the expression of TNF-alpha m-RNA and synthesis of TNF-alpha in cells from leprosy patients with reversal reaction .
17465495	0	thalidomide	29,40	TNF-alpha	89,98	thalidomide	TNF-alpha	MESH:D013792	24835(Tax:10116)	Chemical	Gene	START_ENTITY|dep|effects effects|nmod|END_ENTITY	Therapeutic and prophylactic thalidomide in TNBS-induced colitis : synergistic effects on TNF-alpha , IL-12 and VEGF production .
19394719	0	thalidomide	30,41	TNF-alpha	85,94	thalidomide	TNF-alpha	MESH:D013792	7124	Chemical	Gene	analogue|nmod|START_ENTITY analogue|acl:relcl|used used|nmod|modulator modulator|nmod|production production|amod|END_ENTITY	Discovering a new analogue of thalidomide which may be used as a potent modulator of TNF-alpha production .
8900028	0	thalidomide	52,63	TNF-alpha	31,40	thalidomide	TNF-alpha	MESH:D013792	7124	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|inhibition inhibition|nmod|END_ENTITY	Enantioselective inhibition of TNF-alpha release by thalidomide and thalidomide-analogues .
9780198	0	thalidomide	35,46	TNF-alpha	90,99	thalidomide	TNF-alpha	MESH:D013792	7124	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|nmod|production production|amod|END_ENTITY	CC-3052 : a water-soluble analog of thalidomide and potent inhibitor of activation-induced TNF-alpha production .
25092564	0	thalidomide	93,104	TRAIL	81,86	thalidomide	TRAIL	MESH:D013792	8743	Chemical	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	A multicenter , open-label phase II study of recombinant CPT -LRB- Circularly Permuted TRAIL -RRB- plus thalidomide in patients with relapsed and refractory multiple_myeloma .
16475152	0	thalidomide	20,31	interleukin-2	52,65	thalidomide	interleukin-2	MESH:D013792	3558	Chemical	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	Phase I/II study of thalidomide in combination with interleukin-2 in patients with metastatic_renal_cell_carcinoma .
12525736	0	thalidomide	17,28	neurofibromatosis_1	76,95	thalidomide	neurofibromatosis 1	MESH:D013792	4763	Chemical	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	Phase I study of thalidomide for the treatment of plexiform_neurofibroma in neurofibromatosis_1 .
15136218	0	thalidomide	85,96	p55	60,63	thalidomide	p55	MESH:D013792	7132	Chemical	Gene	predicts|advcl|START_ENTITY predicts|nsubj|END_ENTITY	A low serum level of soluble tumor necrosis factor receptor p55 predicts response to thalidomide in advanced multiple myeloma .
22966360	0	thalidomide	10,21	tumor_necrosis_factor-a	61,84	thalidomide	tumor necrosis factor-a	MESH:D013792	7124	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|release release|nmod|END_ENTITY	Effect of thalidomide and arsenic_trioxide on the release of tumor_necrosis_factor-a and vascular_endothelial_growth_factor from the KG-1a human acute_myelogenous_leukemia cell line .
11354662	0	thalidomide	17,28	tumor_necrosis_factor-alpha	72,99	thalidomide	tumor necrosis factor-alpha	MESH:D013792	7124	Chemical	Gene	analogues|nmod|START_ENTITY analogues|dep|synthesis synthesis|nmod|inhibitors inhibitors|nmod|production production|amod|END_ENTITY	Aza analogues of thalidomide : synthesis and evaluation as inhibitors of tumor_necrosis_factor-alpha production in vitro .
12200397	0	thalidomide	89,100	tumor_necrosis_factor-alpha	21,48	thalidomide	tumor necrosis factor-alpha	MESH:D013792	7124	Chemical	Gene	therapy|amod|START_ENTITY predict|nmod|therapy predict|nsubj|Polymorphisms Polymorphisms|nmod|promoter promoter|amod|END_ENTITY	Polymorphisms of the tumor_necrosis_factor-alpha gene promoter predict for outcome after thalidomide therapy in relapsed and refractory multiple_myeloma .
16815871	0	thalidomide	72,83	tumor_necrosis_factor-alpha	87,114	thalidomide	tumor necrosis factor-alpha	MESH:D013792	24835(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	A mechanistic study on reduced toxicity of irinotecan by coadministered thalidomide , a tumor_necrosis_factor-alpha inhibitor .
8177242	0	thalidomide	45,56	tumor_necrosis_factor-alpha	14,41	thalidomide	tumor necrosis factor-alpha	MESH:D013792	24835(Tax:10116)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of tumor_necrosis_factor-alpha by thalidomide in magnesium deficiency .
8702405	0	thalidomide	45,56	tumor_necrosis_factor-alpha	83,110	thalidomide	tumor necrosis factor-alpha	MESH:D013792	7124	Chemical	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Inducer-specific bidirectional regulation by thalidomide and phenylphthalimides of tumor_necrosis_factor-alpha production .
8806653	0	thalidomide	56,67	tumor_necrosis_factor-alpha	94,121	thalidomide	tumor necrosis factor-alpha	MESH:D013792	7124	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|production production|amod|END_ENTITY	Cell type - / inducer-specific bidirectional regulation by thalidomide and phenylphthalimides of tumor_necrosis_factor-alpha production and its enantio-dependence .
8135786	0	thalidomide	82,93	tumor_necrosis_factor_alpha	51,78	thalidomide	tumor necrosis factor alpha	MESH:D013792	7124	Chemical	Gene	Enhancement|nmod|START_ENTITY Enhancement|nmod|END_ENTITY	Enhancement of phorbol_ester-induced production of tumor_necrosis_factor_alpha by thalidomide .
8755512	0	thalidomide	11,22	tumor_necrosis_factor_alpha	88,115	thalidomide	tumor necrosis factor alpha	MESH:D013792	7124	Chemical	Gene	Binding|nmod|START_ENTITY involved|nsubjpass|Binding involved|nmod|inhibition inhibition|nmod|production production|compound|END_ENTITY	Binding of thalidomide to alpha1-acid glycoprotein may be involved in its inhibition of tumor_necrosis_factor_alpha production .
8827720	0	thalidomide	30,41	tumor_necrosis_factor_alpha	56,83	thalidomide	tumor necrosis factor alpha	MESH:D013792	7124	Chemical	Gene	Selection|nmod|START_ENTITY Selection|nmod|activity activity|compound|END_ENTITY	Selection of novel analogs of thalidomide with enhanced tumor_necrosis_factor_alpha inhibitory activity .
15060740	0	thalidomide	14,25	tumour_necrosis_factor	132,154	thalidomide	tumour necrosis factor	MESH:D013792	21926(Tax:10090)	Chemical	Gene	pharmacokinetics|amod|START_ENTITY Modulation|nmod|pharmacokinetics Modulation|dep|role role|nmod|END_ENTITY	Modulation of thalidomide pharmacokinetics by cyclophosphamide or 5,6-dimethylxanthenone-4-acetic _ acid -LRB- DMXAA -RRB- in mice : the role of tumour_necrosis_factor .
7640215	0	thalidomide	10,21	tumour_necrosis_factor	25,47	thalidomide	tumour necrosis factor	MESH:D013792	21926(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Effect of thalidomide on tumour_necrosis_factor production and anti-tumour activity induced by 5,6-dimethylxanthenone-4-acetic _ acid .
23426142	0	thalidomide	10,21	vascular_endothelial_growth_factor	43,77	thalidomide	vascular endothelial growth factor	MESH:D013792	83785(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	Effect of thalidomide on the expression of vascular_endothelial_growth_factor in a rat model of liver_regeneration .
10979585	0	thallium	11,19	ATP-ase	23,30	thallium	ATP-ase	MESH:D013793	1769	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	-LSB- Effect of thallium of ATP-ase activity and transmembrane potential in bacteria -RSB- .
16713275	0	thallium	68,76	NRCAM	62,67	thallium	NRCAM	MESH:D013793	4897	Chemical	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	Analysis of neutron and gamma-ray streaming along the maze of NRCAM thallium production target room .
1830305	0	thapsigargin	66,78	ATPase	56,62	thapsigargin	ATPase	MESH:D019284	1769	Chemical	Gene	+|nmod|START_ENTITY +|dobj|END_ENTITY	Inhibition of the sarcoplasmic reticulum Ca2 + transport ATPase by thapsigargin at subnanomolar concentrations .
11276013	0	thapsigargin	64,76	Bcl-2	95,100	thapsigargin	Bcl-2	MESH:D019284	596	Chemical	Gene	response|nmod|START_ENTITY response|nmod|END_ENTITY	Differential expression of cell death regulators in response to thapsigargin and adriamycin in Bcl-2 transfected DU145 prostatic_cancer cells .
8842514	0	thapsigargin	80,92	Bcl-2	0,5	thapsigargin	Bcl-2	MESH:D019284	12043(Tax:10090)	Chemical	Gene	cells|amod|START_ENTITY apoptosis|nmod|cells inhibit|dobj|apoptosis fluxes|xcomp|inhibit fluxes|nsubj|acts acts|amod|END_ENTITY	Bcl-2 acts subsequent to and independent of Ca2 + fluxes to inhibit apoptosis in thapsigargin - and glucocorticoid-treated mouse_lymphoma cells .
1714585	0	thapsigargin	86,98	c-fos	14,19	thapsigargin	c-fos	MESH:D019284	14281(Tax:10090)	Chemical	Gene	Ca|dep|START_ENTITY protooncogene|nmod|Ca protooncogene|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of c-fos and c-jun protooncogene expression by the Ca -LRB- 2 + -RRB- - ATPase inhibitor thapsigargin .
18457829	0	thapsigargin	53,65	interferon-gamma	121,137	thapsigargin	interferon-gamma	MESH:D019284	15978(Tax:10090)	Chemical	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Inhibitor of sarco-endoplasmic_reticulum_Ca2 + - ATPase thapsigargin stimulates production of nitric_oxide and secretion of interferon-gamma .
21184129	0	theaflavin	21,31	ICAM-1	55,61	theaflavin	ICAM-1	MESH:C056068	25464(Tax:10116)	Chemical	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	Black tea polyphenol theaflavin suppresses LPS-induced ICAM-1 and VCAM-1 expression via blockage of NF-kB and JNK activation in intestinal epithelial cells .
19453155	0	thelephantin_G	23,37	TNF-alpha	93,102	thelephantin G	TNF-alpha	null	24835(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Structural revision of thelephantin_G by total synthesis and the inhibitory activity against TNF-alpha production .
2422018	0	theophylline	20,32	Avidin	0,6	theophylline	Avidin	MESH:D013806	396260(Tax:9031)	Chemical	Gene	induction|nmod|START_ENTITY induction|nsubj|END_ENTITY	Avidin induction by theophylline in vivo and in vitro .
10596698	0	theophylline	11,23	CD4	108,111	theophylline	CD4	MESH:D013806	920	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|T-cells T-cells|compound|END_ENTITY	Effects of theophylline , dexamethasone and salbutamol on cytokine gene expression in human peripheral blood CD4 + T-cells .
11918854	0	theophylline	11,23	CD4	27,30	theophylline	CD4	MESH:D013806	920	Chemical	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Effects of theophylline on CD4 + T lymphocyte , interleukin-5 , and interferon_gamma in induced sputum of asthmatic subjects .
3297523	0	theophylline	36,48	COPD	52,56	theophylline	COPD	MESH:D013806	260431	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Favorable cardiovascular effects of theophylline in COPD .
8283362	0	theophylline	29,41	Erythropoietin	0,14	theophylline	Erythropoietin	MESH:D013806	2056	Chemical	Gene	treatment|amod|START_ENTITY levels|nmod|treatment levels|compound|END_ENTITY	Erythropoietin levels during theophylline treatment in premature infants .
1890280	0	theophylline	109,121	GHRH	55,59	theophylline	GHRH	MESH:D013806	2691	Chemical	Gene	amounts|nmod|START_ENTITY infusion|nmod|amounts END_ENTITY|nmod|infusion	Restoration of normal growth_hormone responsiveness to GHRH in normal aged men by infusion of low amounts of theophylline .
3092529	2	theophylline	244,256	GHRH	358,362	theophylline	GHRH	MESH:D013806	2691	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	In the present study the effect of theophylline on the GH-responsiveness to acute and continuous administration of growth_hormone_releasing_hormone -LRB- GHRH -RRB- was investigated .
16423372	0	theophylline	81,93	cytochrome_P450	112,127	theophylline	cytochrome P450	MESH:D013806	25251(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of a newly developed ketolide antibiotic , telithromycin , on metabolism of theophylline and expression of cytochrome_P450 in rats .
1137731	0	theophylline	95,107	dopamine-beta-hydroxylase	24,49	theophylline	dopamine-beta-hydroxylase	MESH:D013806	1621	Chemical	Gene	administration|nmod|START_ENTITY END_ENTITY|nmod|administration	Changes of human plasma dopamine-beta-hydroxylase activity after intravenous administration of theophylline .
10705222	0	theophylline	11,23	eosinophil_cationic_protein	38,65	theophylline	eosinophil cationic protein	MESH:D013806	6037	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|END_ENTITY	Once-daily theophylline reduces serum eosinophil_cationic_protein and eosinophil levels in induced sputum of asthmatics .
9461728	0	theophylline	39,51	eosinophil_cationic_protein	59,86	theophylline	eosinophil cationic protein	MESH:D013806	6037	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	-LSB- The effect of an isotonic solution of theophylline 300 on eosinophil_cationic_protein levels -RSB- .
2163024	0	theophylline	11,23	erythropoietin	27,41	theophylline	erythropoietin	MESH:D013806	2056	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|production production|compound|END_ENTITY	Effects of theophylline on erythropoietin production in normal subjects and in patients with erythrocytosis after renal transplantation .
8197042	0	theophylline	43,55	erythropoietin	59,73	theophylline	erythropoietin	MESH:D013806	2056	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|levels levels|compound|END_ENTITY	The effect of short-term administration of theophylline on erythropoietin levels in healthy adults .
9625339	0	theophylline	29,41	erythropoietin	64,78	theophylline	erythropoietin	MESH:D013806	2056	Chemical	Gene	effects|nmod|START_ENTITY Comparison|nmod|effects Comparison|nmod|concentration concentration|compound|END_ENTITY	Comparison of the effects of theophylline and caffeine on serum erythropoietin concentration in premature infants .
1890280	0	theophylline	109,121	growth_hormone	22,36	theophylline	growth hormone	MESH:D013806	2688	Chemical	Gene	amounts|nmod|START_ENTITY infusion|nmod|amounts GHRH|nmod|infusion responsiveness|xcomp|GHRH responsiveness|nsubj|Restoration Restoration|nmod|END_ENTITY	Restoration of normal growth_hormone responsiveness to GHRH in normal aged men by infusion of low amounts of theophylline .
3146595	0	theophylline	11,23	growth_hormone	40,54	theophylline	growth hormone	MESH:D013806	2688	Chemical	Gene	infusion|amod|START_ENTITY infusion|nmod|END_ENTITY	Effects of theophylline infusion on the growth_hormone -LRB- GH -RRB- and prolactin response to GH-releasing hormone administration in acromegaly .
4172452	0	theophylline	73,85	growth_hormone	11,25	theophylline	growth hormone	MESH:D013806	2688	Chemical	Gene	Effects|acl|START_ENTITY Effects|nmod|END_ENTITY	Effects of growth_hormone on the lipolytic response of adipose tissue to theophylline .
8919920	0	theophylline	43,55	growth_hormone	15,29	theophylline	growth hormone	MESH:D013806	2688	Chemical	Gene	secretion|nmod|START_ENTITY secretion|amod|END_ENTITY	-LSB- Inhibition of growth_hormone secretion by theophylline in asthmatic children -RSB- .
12840867	0	theophylline	11,23	interleukin-4	44,57	theophylline	interleukin-4	MESH:D013806	3565	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|nmod|END_ENTITY	Effects of theophylline on plasma levels of interleukin-4 , cyclic nucleotides and pulmonary functions in patients with chronic_obstructive_pulmonary_disease .
6213372	0	theophylline	14,26	macrophage_elastase	30,49	theophylline	macrophage elastase	MESH:D013806	17381(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|amod|END_ENTITY	The effect of theophylline on macrophage_elastase secretion .
15708966	0	theophylline	74,86	organic_anion_transporter_2	24,51	theophylline	organic anion transporter 2	MESH:D013806	10864	Chemical	Gene	interaction|nmod|START_ENTITY END_ENTITY|nmod|interaction	Possible involvement of organic_anion_transporter_2 on the interaction of theophylline with erythromycin in the human liver .
955329	0	theophylline_ethylenediamine	26,54	gastrin	64,71	theophylline ethylenediamine	gastrin	MESH:D000628	2520	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|concentration concentration|compound|END_ENTITY	The effect of intravenous theophylline_ethylenediamine on serum gastrin concentration in control subjects and patients with duodenal ulcers and Zollinger-Ellison_syndrome .
15661493	0	thiadiazolidinones	98,116	glycogen_synthase_kinase-3_beta	43,74	thiadiazolidinones	glycogen synthase kinase-3 beta	null	2932	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Application of graph theory : prediction of glycogen_synthase_kinase-3_beta inhibitory activity of thiadiazolidinones as potential drugs for the treatment of Alzheimer 's _ disease .
11881998	0	thiadiazolidinones	82,100	glycogen_synthase_kinase_3_beta	26,57	thiadiazolidinones	glycogen synthase kinase 3 beta	null	2932	Chemical	Gene	inhibitors|dobj|START_ENTITY inhibitors|nsubj|END_ENTITY	First non-ATP competitive glycogen_synthase_kinase_3_beta -LRB- GSK-3beta -RRB- inhibitors : thiadiazolidinones -LRB- TDZD -RRB- as potential drugs for the treatment of Alzheimer 's _ disease .
9235906	0	thiamin	36,43	THI10	60,65	thiamin	THI10	CHEBI:33283	850938(Tax:4932)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Isolation and characterization of a thiamin transport gene , THI10 , from Saccharomyces_cerevisiae .
4729804	0	thiamin	11,18	cytochrome_P-450	71,87	thiamin	cytochrome P-450	CHEBI:33283	25251(Tax:10116)	Chemical	Gene	antagonists|compound|START_ENTITY Effects|nmod|antagonists Effects|nmod|END_ENTITY	Effects of thiamin antagonists on drug hydroxylation and properties of cytochrome_P-450 in the rat .
24961373	0	thiamine	24,32	OCT1	0,4	thiamine	OCT1	MESH:D013831	20517(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|nsubj|END_ENTITY	OCT1 is a high-capacity thiamine transporter that regulates hepatic_steatosis and is a target of metformin .
10978358	0	thiamine	24,32	SLC19A2	71,78	thiamine	SLC19A2	MESH:D013831	10560	Chemical	Gene	responsive|amod|START_ENTITY gene|amod|responsive mutation|nmod|gene END_ENTITY|nsubj|mutation	A novel mutation in the thiamine responsive megaloblastic_anaemia gene SLC19A2 in a patient with deficiency_of_respiratory_chain_complex_I .
16642288	0	thiamine	39,47	SLC19A2	12,19	thiamine	SLC19A2	MESH:D013831	116914(Tax:10090)	Chemical	Gene	transporter|amod|START_ENTITY Deletion|appos|transporter Deletion|nmod|END_ENTITY	Deletion of SLC19A2 , the high affinity thiamine transporter , causes selective inner hair cell loss and an auditory_neuropathy phenotype .
24355766	0	thiamine	57,65	SLC19A2	23,30	thiamine	SLC19A2	MESH:D013831	10560	Chemical	Gene	START_ENTITY|nsubj|Identification Identification|nmod|mutations mutations|nummod|END_ENTITY	Identification of four SLC19A2 mutations in four Chinese thiamine responsive megaloblastic_anemia patients without diabetes .
11731220	0	thiamine	25,33	SLC19A3	0,7	thiamine	SLC19A3	MESH:D013831	80704	Chemical	Gene	ThTr2|amod|START_ENTITY encodes|dobj|ThTr2 encodes|nsubj|END_ENTITY	SLC19A3 encodes a second thiamine transporter ThTr2 .
20930543	0	thiamine	49,57	SLC19A3	71,78	thiamine	SLC19A3	MESH:D013831	80704	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Hypoxia induced upregulation and function of the thiamine transporter , SLC19A3 in a breast_cancer cell line .
20930543	2	thiamine	532,540	SLC19A3	554,561	thiamine	SLC19A3	MESH:D013831	80704	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Using a real time PCR array strategy to further characterize changes in transporter expression within a chronic hypoxia_breast_cancer cell line model -LRB- BT474 -RRB- , we have found a 31 fold increase in the expression of the thiamine transporter , SLC19A3 .
23469184	0	thiamine	62,70	SLC19A3	86,93	thiamine	SLC19A3	MESH:D013831	486151(Tax:9615)	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Genome-wide association analysis identifies a mutation in the thiamine transporter 2 -LRB- SLC19A3 -RRB- gene associated with Alaskan Husky_encephalopathy .
11592824	0	thiamine	43,51	Slc19a2	65,72	thiamine	Slc19a2	MESH:D013831	116914(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Characterization of a murine high-affinity thiamine transporter , Slc19a2 .
12031504	0	thiamine	68,76	Slc19a2	102,109	thiamine	Slc19a2	MESH:D013831	116914(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|THTR-1 THTR-1|appos|END_ENTITY	Identification of transcriptional start sites and splicing of mouse thiamine transporter gene THTR-1 -LRB- Slc19a2 -RRB- .
12454006	0	thiamine	26,34	hTHTR1	50,56	thiamine	hTHTR1	MESH:D013831	10560	Chemical	Gene	transporter-1|compound|START_ENTITY transporter-1|appos|END_ENTITY	Cell biology of the human thiamine transporter-1 -LRB- hTHTR1 -RRB- .
16790503	0	thiamine	65,73	hTHTR2	88,94	thiamine	hTHTR2	MESH:D013831	80704	Chemical	Gene	transport|amod|START_ENTITY transport|nmod|END_ENTITY	Biotin-responsive_basal_ganglia_disease-linked mutations inhibit thiamine transport via hTHTR2 : biotin is not a substrate for hTHTR2 .
25484137	0	thiamine	65,73	miR-155	47,54	thiamine	miR-155	MESH:D013831	406947	Chemical	Gene	level|compound|START_ENTITY level|amod|END_ENTITY	Bioinformatic and metabolomic analysis reveals miR-155 regulates thiamine level in breast_cancer .
21848803	0	thiamine	24,32	prion_protein	4,17	thiamine	prion protein	MESH:D013831	5621	Chemical	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	The prion_protein binds thiamine .
11286512	0	thiamine	42,50	slc19a2	12,19	thiamine	slc19a2	MESH:D013831	10560	Chemical	Gene	transporter|amod|START_ENTITY encoding|dobj|transporter .3|acl|encoding END_ENTITY|nmod|.3	Analysis of slc19a2 , on 1q23 .3 encoding a thiamine transporter as a candidate gene for type 2 diabetes_mellitus in pima indians .
24148759	0	thiamine_pyrophosphate	99,121	DmTpc1	139,145	thiamine pyrophosphate	DmTpc1	MESH:D013835	41316(Tax:7227)	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Transport of platinum bonded nucleotides into proteoliposomes , mediated by Drosophila_melanogaster thiamine_pyrophosphate carrier protein -LRB- DmTpc1 -RRB- .
23872534	0	thiamine_pyrophosphate	44,66	SLC25A19	79,87	thiamine pyrophosphate	SLC25A19	MESH:D013835	60386	Chemical	Gene	transporter|compound|START_ENTITY Characterization|nmod|transporter END_ENTITY|nsubj|Characterization	Characterization of the human mitochondrial thiamine_pyrophosphate transporter SLC25A19 minimal promoter : a role for NF-Y in regulating basal transcription .
26828122	0	thiamine_pyrophosphate	18,40	hTPPT	54,59	thiamine pyrophosphate	hTPPT	MESH:D013835	80736	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	The human colonic thiamine_pyrophosphate transporter -LRB- hTPPT -RRB- is a glycoprotein and N-linked glycosylation is important for its function .
26457526	0	thiamine_pyrophosphate	100,122	transketolase	55,68	thiamine pyrophosphate	transketolase	MESH:D013835	3978327(Tax:362948)	Chemical	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	High-resolution structures of Lactobacillus_salivarius transketolase in the presence and absence of thiamine_pyrophosphate .
8325361	0	thiamine_thiazolone_diphosphate	51,82	transketolase	21,34	thiamine thiazolone diphosphate	transketolase	MESH:C014222	7086	Chemical	Gene	complex|nmod|START_ENTITY END_ENTITY|nmod|complex	Crystal structure of transketolase in complex with thiamine_thiazolone_diphosphate , an analogue of the reaction intermediate , at 2.3 A resolution .
19194547	0	thiazide	11,19	TRPV5	41,46	thiazide	TRPV5	CHEBI:50264	116469(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effects of thiazide on the expression of TRPV5 , calbindin-D28K , and sodium transporters in hypercalciuric rats .
23424237	0	thiazide	45,53	angiotensin-converting_enzyme	57,86	thiazide	angiotensin-converting enzyme	CHEBI:50264	1636	Chemical	Gene	adding|dobj|START_ENTITY adding|nmod|inhibitor inhibitor|amod|END_ENTITY	Effects on insulin action of adding low-dose thiazide to angiotensin-converting_enzyme inhibitor in essential hypertension .
17159081	0	thiazide	92,100	renin	55,60	thiazide	renin	CHEBI:50264	5972	Chemical	Gene	diuretic|amod|START_ENTITY suppresses|nmod|diuretic suppresses|dobj|activity activity|compound|END_ENTITY	Aliskiren reduces blood pressure and suppresses plasma renin activity in combination with a thiazide diuretic , an angiotensin-converting enzyme inhibitor , or an angiotensin receptor blocker .
21261619	0	thiazide	51,59	renin	21,26	thiazide	renin	CHEBI:50264	5972	Chemical	Gene	diuretics|amod|START_ENTITY effects|nmod|diuretics predicts|dobj|effects predicts|nsubj|variation variation|nmod|END_ENTITY	Genetic variation in renin predicts the effects of thiazide diuretics .
22311004	0	thiazide	29,37	renin	145,150	thiazide	renin	CHEBI:50264	5972	Chemical	Gene	response|acl|START_ENTITY influenced|nsubjpass|response influenced|nmod|activity activity|compound|END_ENTITY	Antihypertensive response to thiazide diuretic or angiotensin receptor blocker in elderly hypertensives is not influenced by pretreatment plasma renin activity .
2565158	0	thiazide	22,30	renin	42,47	thiazide	renin	CHEBI:50264	5972	Chemical	Gene	START_ENTITY|dobj|secretion secretion|compound|END_ENTITY	Bevantolol attenuates thiazide stimulated renin secretion and catecholamine release in diuretic resistant hypertensives .
3296978	0	thiazide	74,82	renin	13,18	thiazide	renin	CHEBI:50264	5972	Chemical	Gene	diuretics|amod|START_ENTITY Influence|nmod|diuretics Influence|nmod|levels levels|compound|END_ENTITY	Influence of renin levels on the treatment of essential hypertension with thiazide diuretics .
7018804	0	thiazide	24,32	renin	103,108	thiazide	renin	CHEBI:50264	5972	Chemical	Gene	Captopril|nmod|START_ENTITY lowers|nsubj|Captopril lowers|dobj|concentration concentration|dep|implications implications|nmod|methodology methodology|nmod|assays assays|compound|END_ENTITY	Captopril combined with thiazide lowers renin substrate concentration : implications for methodology in renin assays .
7018804	0	thiazide	24,32	renin	40,45	thiazide	renin	CHEBI:50264	5972	Chemical	Gene	Captopril|nmod|START_ENTITY lowers|nsubj|Captopril lowers|dobj|concentration concentration|compound|END_ENTITY	Captopril combined with thiazide lowers renin substrate concentration : implications for methodology in renin assays .
24049735	0	thiazoladinediones	80,98	Fibroblast_growth_factor_21	0,27	thiazoladinediones	Fibroblast growth factor 21	null	56636(Tax:10090)	Chemical	Gene	actions|nmod|START_ENTITY required|nmod|actions required|nsubjpass|END_ENTITY	Fibroblast_growth_factor_21 is not required for the antidiabetic actions of the thiazoladinediones .
21143042	0	thiazole	46,54	neuraminidase	86,99	thiazole	neuraminidase	CHEBI:43732	4758	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|inhibitors inhibitors|compound|END_ENTITY	Design , synthesis , and biological activity of thiazole derivatives as novel influenza neuraminidase inhibitors .
16203144	0	thiazole_carboxamides	28,49	TRPV1	75,80	thiazole carboxamides	TRPV1	null	7442	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Synthesis and evaluation of thiazole_carboxamides as vanilloid receptor 1 -LRB- TRPV1 -RRB- antagonists .
15735430	0	thiazolidenedione	39,56	peroxisome_proliferator-activated_receptor-gamma	57,105	thiazolidenedione	peroxisome proliferator-activated receptor-gamma	CHEBI:50991	5468	Chemical	Gene	ligands|amod|START_ENTITY ligands|amod|END_ENTITY	Intestinal antiinflammatory effects of thiazolidenedione peroxisome_proliferator-activated_receptor-gamma ligands on T helper type 1 chemokine regulation include nontranscriptional control mechanisms .
8004696	0	thiazolidine	34,46	thromboxane_A2_receptor	62,85	thiazolidine	thromboxane A2 receptor	CHEBI:35622	100008908(Tax:9986)	Chemical	Gene	START_ENTITY|nmod|antagonists antagonists|amod|END_ENTITY	Synthesis and evaluation of novel thiazolidine derivatives as thromboxane_A2_receptor antagonists .
21382719	0	thiazolidine-4-carboxylic_acid	45,75	neuraminidase	107,120	thiazolidine-4-carboxylic acid	neuraminidase	MESH:C003438	4758	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Design , synthesis and biological activity of thiazolidine-4-carboxylic_acid derivatives as novel influenza neuraminidase inhibitors .
11411343	0	thiazolidinedione	45,62	Insulin	1,8	thiazolidinedione	Insulin	MESH:C089946	483665(Tax:9615)	Chemical	Gene	-RSB-|amod|START_ENTITY effect|nmod|-RSB- resistance-reducing|dobj|effect resistance-reducing|nsubj|END_ENTITY	-LSB- Insulin resistance-reducing effect of a new thiazolidinedione derivative , pioglitazone -RSB- .
15925327	0	thiazolidinedione	37,54	PPAR	32,36	thiazolidinedione	PPAR	MESH:C089946	5465	Chemical	Gene	agonists|compound|START_ENTITY agonists|amod|END_ENTITY	Receptor-independent actions of PPAR thiazolidinedione agonists : is mitochondrial function the key ?
19052259	0	thiazolidinedione	18,35	PPAR	44,48	thiazolidinedione	PPAR	MESH:C089946	19013(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|affinity affinity|amod|END_ENTITY	BLX-1002 , a novel thiazolidinedione with no PPAR affinity , stimulates AMP-activated protein kinase activity , raises cytosolic Ca2 + , and enhances glucose-stimulated insulin secretion in a PI3K-dependent manner .
11078801	0	thiazolidinedione	18,35	PPARgamma	0,9	thiazolidinedione	PPARgamma	MESH:C089946	5468	Chemical	Gene	induces|nsubj|START_ENTITY ligand|ccomp|induces ligand|nsubj|END_ENTITY	PPARgamma ligand -LRB- thiazolidinedione -RRB- induces growth_arrest and differentiation markers of human pancreatic_cancer cells .
14713549	0	thiazolidinedione	57,74	PPARgamma	75,84	thiazolidinedione	PPARgamma	MESH:C089946	19016(Tax:10090)	Chemical	Gene	agonists|amod|START_ENTITY agonists|compound|END_ENTITY	Promotion of colon_tumors in C57BL/6J-APC -LRB- min -RRB- / + mice by thiazolidinedione PPARgamma agonists and a structurally unrelated PPARgamma agonist .
9570344	0	thiazolidinedione	145,162	PPARgamma	111,120	thiazolidinedione	PPARgamma	MESH:C089946	19016(Tax:10090)	Chemical	Gene	ligand|appos|START_ENTITY ligand|compound|END_ENTITY	Counteraction of retinoic_acid and 1,25-dihydroxyvitamin _ D3 on up-regulation of adipocyte differentiation with PPARgamma ligand , an antidiabetic thiazolidinedione , in 3T3-L1 cells .
20739195	0	thiazolidinedione	80,97	PPARy	24,29	thiazolidinedione	PPARy	MESH:C089946	5468	Chemical	Gene	side-effects|compound|START_ENTITY lower|nmod|side-effects lower|nsubj|modulation modulation|nmod|activity activity|compound|END_ENTITY	Selective modulation of PPARy activity can lower plasma glucose without typical thiazolidinedione side-effects in patients with Type 2 diabetes .
21246057	6	thiazolidinedione	1258,1275	PPARy	1326,1331	thiazolidinedione	BACE1	MESH:C089946	23621	Chemical	Gene	peroxisome_proliferator-activated_receptor_gamma|amod|START_ENTITY peroxisome_proliferator-activated_receptor_gamma|appos|END_ENTITY	Use of the thiazolidinedione peroxisome_proliferator-activated_receptor_gamma -LRB- PPARy -RRB- agonist rosiglitazone , the irreversible PPARy antagonist GW9662 , and overexpressing PPARy suggests that the NPD1-mediated down-regulation of BACE1 and Ab42 peptide release is PPARy-dependent .
22512587	0	thiazolidinedione	56,73	PPARy	74,79	thiazolidinedione	PPARy	MESH:C089946	5468	Chemical	Gene	agonists|amod|START_ENTITY agonists|compound|END_ENTITY	A review on the development in the field of NIDDM based thiazolidinedione PPARy agonists .
26825076	0	thiazolidinedione	29,46	PPARy	47,52	thiazolidinedione	PPARy	MESH:C089946	5468	Chemical	Gene	agonist|amod|START_ENTITY agonist|compound|END_ENTITY	Genotoxic investigation of a thiazolidinedione PPARy agonist using the in vitro micronucleus test and the in vivo homozygotization assay .
12519830	0	thiazolidinedione	94,111	Peroxisome_proliferator-activated_receptor-gamma	0,48	thiazolidinedione	Peroxisome proliferator-activated receptor-gamma	MESH:C089946	5468	Chemical	Gene	use|amod|START_ENTITY contraindication|nmod|use END_ENTITY|dep|contraindication	Peroxisome_proliferator-activated_receptor-gamma in thyroid_eye_disease : contraindication for thiazolidinedione use ?
17410715	0	thiazolidinedione	148,165	peroxisome_proliferator-activated_receptor-gamma	99,147	thiazolidinedione	peroxisome proliferator-activated receptor-gamma	MESH:C089946	19016(Tax:10090)	Chemical	Gene	agonists|compound|START_ENTITY agonists|amod|END_ENTITY	Prolonged survival of mice with established intracerebral_glioma receiving combined treatment with peroxisome_proliferator-activated_receptor-gamma thiazolidinedione agonists and interleukin-2-secreting syngeneic/allogeneic fibroblasts .
11092504	0	thiazolidinedione	57,74	peroxisome_proliferator_activated_receptor_gamma	85,133	thiazolidinedione	peroxisome proliferator activated receptor gamma	MESH:C089946	25664(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Euglycemic and hypolipidemic activity of PAT5A : a unique thiazolidinedione with weak peroxisome_proliferator_activated_receptor_gamma activity .
12626651	0	thiazolidinedione_darglitazone	102,132	peroxisome_proliferator-activated_receptor-gamma	143,191	thiazolidinedione darglitazone	peroxisome proliferator-activated receptor-gamma	null	25664(Tax:10116)	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Mechanism and implications of brown adipose tissue proliferation in rats and monkeys treated with the thiazolidinedione_darglitazone , a potent peroxisome_proliferator-activated_receptor-gamma agonist .
12927809	0	thiazolidinediones	31,49	Adiponectin	0,11	thiazolidinediones	Adiponectin	MESH:D045162	9370	Chemical	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Adiponectin gene activation by thiazolidinediones requires PPAR_gamma 2 , but not C/EBP _ alpha-evidence for differential regulation of the aP2 and adiponectin genes .
15270782	0	thiazolidinediones	144,162	C-reactive_protein	0,18	thiazolidinediones	C-reactive protein	MESH:D045162	1401	Chemical	Gene	Type|nmod|START_ENTITY Type|nsubj|END_ENTITY	C-reactive_protein , its role in inflammation , Type 2 diabetes and cardiovascular_disease , and the effects of insulin-sensitizing treatment with thiazolidinediones .
16490432	0	thiazolidinediones	31,49	C-reactive_protein	59,77	thiazolidinediones	C-reactive protein	MESH:D045162	1401	Chemical	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	Meta-analysis of the effect of thiazolidinediones on serum C-reactive_protein levels .
20926154	0	thiazolidinediones	15,33	C-reactive_protein	49,67	thiazolidinediones	C-reactive protein	MESH:D045162	1401	Chemical	Gene	START_ENTITY|acl|circulating circulating|dobj|levels levels|amod|END_ENTITY	The impacts of thiazolidinediones on circulating C-reactive_protein levels in different diseases : a meta-analysis .
11179452	0	thiazolidinediones	61,79	Fos-related_antigen_1	25,46	thiazolidinediones	Fos-related antigen 1	MESH:D045162	14283(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	The transcription factor Fos-related_antigen_1 is induced by thiazolidinediones during differentiation of 3T3-L1 cells .
12379175	0	thiazolidinediones	51,69	Insulin	0,7	thiazolidinediones	Insulin	MESH:D045162	3630	Chemical	Gene	resistance|dep|START_ENTITY resistance|compound|END_ENTITY	Insulin resistance , diabetes , and atherosclerosis : thiazolidinediones as therapeutic interventions .
14678870	0	thiazolidinediones	38,56	Insulin	0,7	thiazolidinediones	Insulin	MESH:D045162	3630	Chemical	Gene	resistance|nmod|START_ENTITY resistance|amod|END_ENTITY	Insulin resistance and the effects of thiazolidinediones on cardiac metabolism .
19776663	0	thiazolidinediones	15,33	P-glycoprotein	90,104	thiazolidinediones	P-glycoprotein	MESH:D045162	5243	Chemical	Gene	Interaction|nmod|START_ENTITY transporters|nsubj|Interaction transporters|xcomp|END_ENTITY	Interaction of thiazolidinediones -LRB- glitazones -RRB- with the ATP-binding cassette transporters P-glycoprotein and breast_cancer_resistance_protein .
15072549	0	thiazolidinediones	20,38	P450c17	53,60	thiazolidinediones	P450c17	MESH:D045162	1586	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|END_ENTITY	Cinnamic_acid based thiazolidinediones inhibit human P450c17 and 3beta-hydroxysteroid dehydrogenase and improve insulin sensitivity independent of PPARgamma agonist activity .
17367502	0	thiazolidinediones	24,42	PPARgamma	0,9	thiazolidinediones	PPARgamma	MESH:D045162	5468	Chemical	Gene	activation|nmod|START_ENTITY END_ENTITY|acl|activation	PPARgamma activation by thiazolidinediones -LRB- TZDs -RRB- may modulate breast_carcinoma outcome : the importance of interplay with TGFbeta signalling .
20099277	0	thiazolidinediones	33,51	PPARgamma	53,62	thiazolidinediones	PPARgamma	MESH:D045162	5468	Chemical	Gene	START_ENTITY|appos|ligand ligand|compound|END_ENTITY	Insights on distinct pathways of thiazolidinediones -LRB- PPARgamma ligand -RRB- - promoted apoptosis in TRAIL-sensitive or - resistant malignant urothelial cells .
8913339	0	thiazolidinediones	63,81	Peroxisome_proliferator-activated_receptor-gamma	0,48	thiazolidinediones	Peroxisome proliferator-activated receptor-gamma	MESH:D045162	5468	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Peroxisome_proliferator-activated_receptor-gamma activation by thiazolidinediones induces adipogenesis in bone marrow stromal cells .
10333043	0	thiazolidinediones	10,28	UCP2	46,50	thiazolidinediones	UCP2	MESH:D045162	7351	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effect of thiazolidinediones on expression of UCP2 and adipocyte markers in human PAZ6 adipocytes .
17645557	0	thiazolidinediones	14,32	adiponectin	36,47	thiazolidinediones	adiponectin	MESH:D045162	9370	Chemical	Gene	START_ENTITY|nmod|level level|amod|END_ENTITY	The effect of thiazolidinediones on adiponectin serum level : a meta-analysis .
19880209	0	thiazolidinediones	59,77	collagen_XVIII	30,44	thiazolidinediones	collagen XVIII	MESH:D045162	80781	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	WITHDRAWN : Down-regulation of collagen_XVIII expression by thiazolidinediones through a PPARgamma-dependent mechanism in human non-small_lung_cancer cells .
11383915	0	thiazolidinediones	52,70	insulin	10,17	thiazolidinediones	insulin	MESH:D045162	3630	Chemical	Gene	Enhancing|nmod|START_ENTITY Enhancing|dobj|action action|compound|END_ENTITY	Enhancing insulin action : from chemical elements to thiazolidinediones .
15228086	0	thiazolidinediones	106,124	insulin	42,49	thiazolidinediones	insulin	MESH:D045162	3630	Chemical	Gene	treated|nmod|START_ENTITY Restoration|acl|treated Restoration|nmod|activation activation|nmod|END_ENTITY	Restoration of impaired p38 activation by insulin in insulin resistant skeletal muscle cells treated with thiazolidinediones .
15228086	0	thiazolidinediones	106,124	insulin	53,60	thiazolidinediones	insulin	MESH:D045162	3630	Chemical	Gene	treated|nmod|START_ENTITY Restoration|acl|treated Restoration|nmod|cells cells|compound|END_ENTITY	Restoration of impaired p38 activation by insulin in insulin resistant skeletal muscle cells treated with thiazolidinediones .
15628822	0	thiazolidinediones	68,86	insulin	10,17	thiazolidinediones	insulin	MESH:D045162	3630	Chemical	Gene	role|nmod|START_ENTITY resistance|dep|role resistance|compound|END_ENTITY	Targeting insulin resistance and beta-cell dysfunction : the role of thiazolidinediones .
23148347	0	thiazolidinediones	3,21	insulin	60,67	thiazolidinediones	insulin	MESH:D045162	3630	Chemical	Gene	use|amod|START_ENTITY factor|nsubj|use factor|acl|delaying delaying|nmod|therapy therapy|compound|END_ENTITY	Is thiazolidinediones use a factor in delaying the need for insulin therapy in type 2 patients with diabetes ?
14747840	0	thiazolidinediones	28,46	peroxisome_proliferator-activated_receptor-gamma	48,96	thiazolidinediones	peroxisome proliferator-activated receptor-gamma	MESH:D045162	5468	Chemical	Gene	START_ENTITY|appos|agonists agonists|amod|END_ENTITY	Cardioprotective effects of thiazolidinediones , peroxisome_proliferator-activated_receptor-gamma agonists .
16480422	0	thiazolidinediones	23,41	peroxisome_proliferator-activated_receptor-gamma	57,105	thiazolidinediones	peroxisome proliferator-activated receptor-gamma	MESH:D045162	19016(Tax:10090)	Chemical	Gene	treatment|nmod|START_ENTITY treatment|appos|activators activators|nmod|END_ENTITY	Topical treatment with thiazolidinediones , activators of peroxisome_proliferator-activated_receptor-gamma , normalizes epidermal homeostasis in a murine hyperproliferative disease model .
19147680	0	thiazolidinediones	135,153	peroxisome_proliferator-activated_receptor-gamma	12,60	thiazolidinediones	peroxisome proliferator-activated receptor-gamma	MESH:D045162	5468	Chemical	Gene	binds|nmod|START_ENTITY binds|nsubj|modulator modulator|amod|END_ENTITY	A selective peroxisome_proliferator-activated_receptor-gamma modulator , telmisartan , binds to the receptor in a different fashion from thiazolidinediones .
15680279	0	thiazolidinediones	25,43	peroxisome_proliferator-activated_receptor_gamma	61,109	thiazolidinediones	peroxisome proliferator-activated receptor gamma	MESH:D045162	5468	Chemical	Gene	potential|nmod|START_ENTITY potential|nmod|END_ENTITY	Therapeutic potential of thiazolidinediones in activation of peroxisome_proliferator-activated_receptor_gamma for monocyte recruitment and endothelial regeneration .
9518257	0	thiazolidinediones	37,55	phosphoenolpyruvate_carboxykinase	86,119	thiazolidinediones	phosphoenolpyruvate carboxykinase	MESH:D045162	362282(Tax:10116)	Chemical	Gene	induction|nmod|START_ENTITY induction|nmod|expression expression|amod|END_ENTITY	Glucocorticoids repress induction by thiazolidinediones , fibrates , and fatty_acids of phosphoenolpyruvate_carboxykinase gene expression in adipocytes .
12588052	0	thiazolidinediones	132,150	uncoupling_protein-2	103,123	thiazolidinediones	uncoupling protein-2	MESH:D045162	7351	Chemical	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Regulation of uncoupling_protein-2 mRNA in L6 myotubules : II : Thyroid hormone amplifies stimulation of uncoupling_protein-2 gene by thiazolidinediones and other peroxisome_proliferator-activated_receptor ligands in L6 myotubules : evidence for a priming effect .
12588052	0	thiazolidinediones	132,150	uncoupling_protein-2	14,34	thiazolidinediones	uncoupling protein-2	MESH:D045162	7351	Chemical	Gene	gene|nmod|START_ENTITY stimulation|nmod|gene II|dep|stimulation Regulation|dep|II Regulation|nmod|mRNA mRNA|amod|END_ENTITY	Regulation of uncoupling_protein-2 mRNA in L6 myotubules : II : Thyroid hormone amplifies stimulation of uncoupling_protein-2 gene by thiazolidinediones and other peroxisome_proliferator-activated_receptor ligands in L6 myotubules : evidence for a priming effect .
15246976	0	thiazolidinone	81,95	CFTR	96,100	thiazolidinone	CFTR	CHEBI:48891	403154(Tax:9823)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	CFTR involvement in nasal potential differences in mice and pigs studied using a thiazolidinone CFTR inhibitor .
24405707	0	thiazolidinones	39,54	CGRP	64,68	thiazolidinones	CGRP	CHEBI:48891	796	Chemical	Gene	Identification|nmod|START_ENTITY END_ENTITY|nsubj|Identification	Identification of potent CNS-penetrant thiazolidinones as novel CGRP receptor antagonists .
16297626	0	thiazolopyrimidine	66,84	CXCR2	85,90	thiazolopyrimidine	CXCR2	CHEBI:64196	3579	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|amod|END_ENTITY	Hit-to-Lead studies : the discovery of potent , orally bioavailable thiazolopyrimidine CXCR2 receptor antagonists .
23504664	0	thiazolyl-carbonyl-thiosemicarbazides	22,59	iNOS	122,126	thiazolyl-carbonyl-thiosemicarbazides	iNOS	null	4843	Chemical	Gene	START_ENTITY|nmod|properties properties|nmod|END_ENTITY	New anti-inflammatory thiazolyl-carbonyl-thiosemicarbazides and thiazolyl-azoles with antioxidant properties as potential iNOS inhibitors .
21802290	0	thiazolyl-pyrazoline	47,67	EGFR	83,87	thiazolyl-pyrazoline	EGFR	null	1956	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|inhibitors inhibitors|compound|END_ENTITY	Synthesis , molecular docking and evaluation of thiazolyl-pyrazoline derivatives as EGFR TK inhibitors and potential anticancer agents .
24374272	0	thiazolylimidazolidinone	89,113	SCD1	128,132	thiazolylimidazolidinone	SCD1	null	6319	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|nmod|END_ENTITY	Systematic evaluation of amide bioisosteres leading to the discovery of novel and potent thiazolylimidazolidinone inhibitors of SCD1 for the treatment of metabolic_diseases .
383012	0	thienamycin	61,72	transpeptidase	14,28	thienamycin	transpeptidase	MESH:C015537	15230062	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activity activity|amod|END_ENTITY	Inhibition of transpeptidase activity in Escherichia_coli by thienamycin .
25130912	6	thienopiridyl	775,788	P2Y12	789,794	thienopiridyl	P2Y12	null	70839(Tax:10090)	Chemical	Gene	antagonist|amod|START_ENTITY antagonist|compound|END_ENTITY	The administration of prasugrel , a thienopiridyl P2Y12 antagonist , did not affect the activation state of circulating platelets suggesting P2Y12 independent mechanism of activation .
15967851	0	thienopyridine	63,77	P2Y12	78,83	thienopyridine	P2Y12	MESH:C446540	64805	Chemical	Gene	antagonist|amod|START_ENTITY antagonist|compound|END_ENTITY	Randomized comparison of prasugrel -LRB- CS-747 , LY640315 -RRB- , a novel thienopyridine P2Y12 antagonist , with clopidogrel in percutaneous coronary intervention : results of the Joint Utilization of Medications to Block Platelets Optimally -LRB- JUMBO -RRB- - TIMI 26 trial .
16769598	0	thienopyridine	80,94	P2Y12	95,100	thienopyridine	P2Y12	MESH:C446540	64805	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	Platelet inhibitory activity and pharmacokinetics of prasugrel -LRB- CS-747 -RRB- a novel thienopyridine P2Y12 inhibitor : a single ascending dose study in healthy humans .
16769599	0	thienopyridine	80,94	P2Y12	95,100	thienopyridine	P2Y12	MESH:C446540	64805	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	Platelet inhibitory activity and pharmacokinetics of prasugrel -LRB- CS-747 -RRB- a novel thienopyridine P2Y12 inhibitor : a multiple-dose study in healthy humans .
17076696	0	thienopyridine	53,67	P2Y12	68,73	thienopyridine	P2Y12	MESH:C446540	64805	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	A multiple dose study of prasugrel -LRB- CS-747 -RRB- , a novel thienopyridine P2Y12 inhibitor , compared with clopidogrel in healthy humans .
10509929	0	thienopyridine_sulfonamide_pyrrolidinones	45,86	factor_Xa	90,99	thienopyridine sulfonamide pyrrolidinones	factor Xa	null	2159	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Synthesis , SAR and in vivo activity of novel thienopyridine_sulfonamide_pyrrolidinones as factor_Xa inhibitors .
19678800	0	thienopyridines	38,53	P2Y12	9,14	thienopyridines	P2Y12	MESH:D058924	64805	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Platelet P2Y12 receptor inhibition by thienopyridines : status and future .
19882081	0	thienopyridines	18,33	P2Y12	0,5	thienopyridines	P2Y12	MESH:D058924	64805	Chemical	Gene	inhibitors|dep|START_ENTITY inhibitors|nummod|END_ENTITY	P2Y12 inhibitors : thienopyridines and direct oral inhibitors .
23476040	0	thienopyridines	38,53	P2Y12	18,23	thienopyridines	P2Y12	MESH:D058924	64805	Chemical	Gene	inhibition|nmod|START_ENTITY END_ENTITY|acl|inhibition	Impaired platelet P2Y12 inhibition by thienopyridines in chronic_kidney_disease : mechanisms , clinical relevance and pharmacological options .
25082125	0	thienopyrimidine	39,55	GPR119	71,77	thienopyrimidine	GPR119	MESH:C476003	236781(Tax:10090)	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Synthesis and biological evaluation of thienopyrimidine derivatives as GPR119 agonists .
14684289	0	thienopyrimidine	18,34	VEGFR-2	68,75	thienopyrimidine	VEGFR-2	MESH:C476003	3791	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Design and SAR of thienopyrimidine and thienopyridine inhibitors of VEGFR-2 kinase activity .
25127154	0	thienopyrimidinones	6,25	mGluR1	29,35	thienopyrimidinones	mGluR1	null	14799(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|antagonists antagonists|amod|END_ENTITY	Novel thienopyrimidinones as mGluR1 antagonists .
23453072	0	thienosultam	43,55	ADAMTS-5	71,79	thienosultam	ADAMTS-5	null	11096	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	Design , synthesis and SAR investigation of thienosultam derivatives as ADAMTS-5 -LRB- aggrecanase-2 -RRB- inhibitors .
11140741	0	thienyl	71,78	p38	0,3	thienyl	p38	CHEBI:37991	1432	Chemical	Gene	inhibitors|dep|START_ENTITY inhibitors|amod|END_ENTITY	p38 kinase inhibitors for the treatment of arthritis and osteoporosis : thienyl , furyl , and pyrrolyl_ureas .
18321638	0	thio-Cl-IB-MECA	76,91	A3_adenosine_receptor	101,122	thio-Cl-IB-MECA	A3 adenosine receptor	MESH:C504222	140	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Inhibition of cell proliferation through cell cycle arrest and apoptosis by thio-Cl-IB-MECA , a novel A3_adenosine_receptor agonist , in human lung_cancer cells .
21514967	0	thio-Cl-IB-MECA	80,95	Akt	118,121	thio-Cl-IB-MECA	Akt	MESH:C504222	11651(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Suppression of inflammation response by a novel A adenosine receptor agonist thio-Cl-IB-MECA through inhibition of Akt and NF-kB signaling .
15808467	0	thio-rofecoxib	130,144	COX-2	158,163	thio-rofecoxib	COX-2	null	4513	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	A general carbometalation , three component coupling strategy for the synthesis of alpha,beta-unsaturated _ gamma-sultines including thio-rofecoxib , a selective COX-2 inhibitor .
1686770	0	thioacetamide	78,91	Gamma-glutamyltranspeptidase	0,28	thioacetamide	Gamma-glutamyltranspeptidase	MESH:D013853	116568(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|END_ENTITY	Gamma-glutamyltranspeptidase -LRB- GGT -RRB- in experimental liver cirrhosis induced by thioacetamide : a biochemical and enzymehistochemical study .
10591148	0	thioacetamide	58,71	caspase-3	12,21	thioacetamide	caspase-3	MESH:D013853	25402(Tax:10116)	Chemical	Gene	Increase|nmod|START_ENTITY Increase|nmod|activity activity|amod|END_ENTITY	Increase of caspase-3 activity in rat liver and plasma by thioacetamide .
6712620	0	thioacetamide	10,23	cytochrome_P-450	27,43	thioacetamide	cytochrome P-450	MESH:D013853	25251(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|synthesis synthesis|amod|END_ENTITY	Effect of thioacetamide on cytochrome_P-450 synthesis in rat liver .
11055553	0	thioacetamide	14,27	glutathione-S-transferase	82,107	thioacetamide	glutathione-S-transferase	MESH:D013853	58962(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|nmod|END_ENTITY	The effect of thioacetamide on the activity and expression of cytosolic rat liver glutathione-S-transferase .
10850955	0	thiocarbamate	43,56	leukocyte_elastase	77,95	thiocarbamate	leukocyte elastase	null	1991	Chemical	Gene	START_ENTITY|dobj|inhibitors inhibitors|nmod|END_ENTITY	Synthesis and mechanism of action of novel thiocarbamate inhibitors of human leukocyte_elastase .
18060772	0	thiocarbazate	41,54	cathepsin_L	55,66	thiocarbazate	cathepsin L	null	1514	Chemical	Gene	Identification|nmod|START_ENTITY END_ENTITY|nsubj|Identification	Identification and synthesis of a unique thiocarbazate cathepsin_L inhibitor .
15698778	0	thiocoumarins	6,19	TNF-alpha	37,46	thiocoumarins	TNF-alpha	null	7124	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Novel thiocoumarins as inhibitors of TNF-alpha induced ICAM-1 expression on human umbilical vein endothelial cells -LRB- HUVECs -RRB- and microsomal lipid peroxidation .
6887917	0	thiocyanate	11,22	androgen_receptor	34,51	thiocyanate	androgen receptor	MESH:C031760	367	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of thiocyanate on cytosol androgen_receptor from Shionogi carcinoma 115 .
16277530	0	thiocyanate	92,103	lactoperoxidase	73,88	thiocyanate	lactoperoxidase	MESH:C031760	4025	Chemical	Gene	oxidation|amod|START_ENTITY END_ENTITY|nmod|oxidation	Autocatalytic modification of the prosthetic heme of horseradish but not lactoperoxidase by thiocyanate oxidation products .
19339248	0	thiocyanate	88,99	lactoperoxidase	113,128	thiocyanate	lactoperoxidase	MESH:C031760	4025	Chemical	Gene	complex|amod|START_ENTITY complex|nmod|END_ENTITY	Structural evidence of substrate specificity in mammalian peroxidases : structure of the thiocyanate complex with lactoperoxidase and its interactions at 2.4 A resolution .
8764284	0	thioglucose	16,27	neuropeptide_Y	31,45	thioglucose	neuropeptide Y	null	109648(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	Effects of gold thioglucose on neuropeptide_Y messenger RNA levels in the mouse hypothalamus .
25985132	0	thioglycolic_acid	56,73	FTO	39,42	thioglycolic acid	FTO	MESH:C017487	79068	Chemical	Gene	protein|nmod|START_ENTITY protein|compound|END_ENTITY	Characterization of the interaction of FTO protein with thioglycolic_acid capped CdTe quantum dots and its analytical application .
25985132	0	thioglycolic_acid	56,73	FTO	39,42	thioglycolic acid	FTO	MESH:C017487	79068	Chemical	Gene	protein|nmod|START_ENTITY protein|compound|END_ENTITY	Characterization of the interaction of FTO protein with thioglycolic_acid capped CdTe quantum dots and its analytical application .
10788430	1	thiol	80,85	ATPase	109,115	thiol	ATPase	CHEBI:29256	3654511(Tax:562)	Chemical	Gene	modulation|amod|START_ENTITY modulation|nmod|END_ENTITY	A kinetic study of the thiol modulation of isolated ATPase and membrane-bound ATP synthase from spinach by Eschericia_coli thioredoxin .
12198183	0	thiol	106,111	GILT	123,127	thiol	GILT	CHEBI:29256	10437	Chemical	Gene	reductase|amod|START_ENTITY reductase|appos|END_ENTITY	Role of the C-terminal propeptide in the activity and maturation of gamma - interferon-inducible lysosomal thiol reductase -LRB- GILT -RRB- .
17142755	0	thiol	42,47	GILT	58,62	thiol	GILT	CHEBI:29256	65972(Tax:10090)	Chemical	Gene	reductase|amod|START_ENTITY requirements|nmod|reductase END_ENTITY|nsubj|requirements	Functional requirements for the lysosomal thiol reductase GILT in MHC class II-restricted antigen processing .
17250895	0	thiol	72,77	GILT	158,162	thiol	GILT	CHEBI:29256	65972(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|gene gene|nmod|Branchiostoma_belcheri Branchiostoma_belcheri|nmod|implications implications|nmod|END_ENTITY	Characterization and expression of gamma-interferon-inducible lysosomal thiol reductase -LRB- GILT -RRB- gene in amphioxus Branchiostoma_belcheri with implications for GILT in innate immune response .
17250895	0	thiol	72,77	GILT	89,93	thiol	GILT	CHEBI:29256	65972(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|gene gene|appos|END_ENTITY	Characterization and expression of gamma-interferon-inducible lysosomal thiol reductase -LRB- GILT -RRB- gene in amphioxus Branchiostoma_belcheri with implications for GILT in innate immune response .
18722674	0	thiol	90,95	GILT	107,111	thiol	GILT	CHEBI:29256	10437	Chemical	Gene	reductase|amod|START_ENTITY reductase|appos|END_ENTITY	Molecular cloning and expression analysis of porcine gamma-interferon-inducible lysosomal thiol reductase -LRB- GILT -RRB- .
21334075	0	thiol	131,136	GILT	148,152	thiol	GILT	CHEBI:29256	100534647	Chemical	Gene	START_ENTITY|dobj|gene gene|appos|END_ENTITY	Molecular structure , phylogenetic analysis , tissue distribution , and function characterization of interferon-y-inducible lysosomal thiol reductase -LRB- GILT -RRB- gene in sheep -LRB- Ovis_aries -RRB- .
23474148	0	thiol	109,114	GILT	126,130	thiol	GILT	CHEBI:29256	420129(Tax:9031)	Chemical	Gene	START_ENTITY|dobj|gene gene|appos|END_ENTITY	Molecular structure , tissue distribution and functional characterization of interferon-y-inducible lysosomal thiol reductase -LRB- GILT -RRB- gene in chicken -LRB- Gallus_gallus -RRB- .
23669023	0	thiol	51,56	GILT	68,72	thiol	GILT	CHEBI:29256	65972(Tax:10090)	Chemical	Gene	Identification|nmod|START_ENTITY reductase|nsubj|Identification reductase|xcomp|gene gene|dep|END_ENTITY	Identification of interferon-y-inducible-lysosomal thiol reductase -LRB- GILT -RRB- gene from Mefugu -LRB- Takifugu obscures -RRB- and its immune response to LPS challenge .
24698993	0	thiol	98,103	GILT	115,119	thiol	GILT	CHEBI:29256	65972(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|gene gene|appos|END_ENTITY	Molecular cloning , expression and functional characterization of interferon-y-inducible lysosomal thiol reductase -LRB- GILT -RRB- gene from mandarin_fish -LRB- Siniperca_chuatsi -RRB- .
26051415	0	thiol	50,55	GILT	67,71	thiol	GILT	CHEBI:29256	10437	Chemical	Gene	reductase|amod|START_ENTITY reductase|appos|END_ENTITY	Identification of three IFN-y inducible lysosomal thiol reductase -LRB- GILT -RRB- - like genes in mud_crab Scylla_paramamosain with distinct gene organizations and patterns of expression .
2478324	0	thiol	22,27	HLA-B27	41,48	thiol	HLA-B27	CHEBI:29256	3106	Chemical	Gene	group|amod|START_ENTITY group|nmod|END_ENTITY	Status of an unpaired thiol group on the HLA-B27 epitope .
8258344	0	thiol	34,39	HLA-B27	26,33	thiol	HLA-B27	CHEBI:29256	3106	Chemical	Gene	group|compound|START_ENTITY group|compound|END_ENTITY	Chemical reactivity of an HLA-B27 thiol group .
27017264	0	thiol	88,93	IMP-1	132,137	thiol	IMP-1	CHEBI:29256	10642	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Design , synthesis , and in vitro and biological evaluation of potent amino_acid-derived thiol inhibitors of the metallo-b-lactamase IMP-1 .
19473973	0	thiol	5,10	MD-2	20,24	thiol	MD-2	CHEBI:29256	17087(Tax:10090)	Chemical	Gene	group|amod|START_ENTITY group|nmod|END_ENTITY	Free thiol group of MD-2 as the target for inhibition of the lipopolysaccharide-induced cell activation .
7491977	0	thiol	67,72	NF-kappa_B	14,24	thiol	NF-kappa B	CHEBI:29256	4790	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of NF-kappa_B and elevation of MnSOD gene expression by thiol reducing agents in lung_adenocarcinoma -LRB- A549 -RRB- cells .
9448725	0	thiol	114,119	NF-kappa_B	14,24	thiol	NF-kappa B	CHEBI:29256	4790	Chemical	Gene	mechanism|amod|START_ENTITY evidence|nmod|mechanism Inhibition|dep|evidence Inhibition|acl|END_ENTITY	Inhibition of NF-kappa_B binding to DNA by chromium , cadmium , mercury , zinc , and arsenite in vitro : evidence of a thiol mechanism .
4064250	0	thiol	14,19	O6-methylguanine-DNA_methyltransferase	48,86	thiol	O6-methylguanine-DNA methyltransferase	CHEBI:29256	4255	Chemical	Gene	depletion|amod|START_ENTITY depletion|nmod|END_ENTITY	Cytotoxicity , thiol depletion and inhibition of O6-methylguanine-DNA_methyltransferase by various aldehydes in cultured human bronchial fibroblasts .
21036150	0	thiol	72,77	Orp1	67,71	thiol	Orp1	CHEBI:29256	6101	Chemical	Gene	peroxidase|amod|START_ENTITY peroxidase|amod|END_ENTITY	The role of active site residues in the oxidant specificity of the Orp1 thiol peroxidase .
6193011	1	thiol	355,360	alpha_2M	374,382	thiol	alpha 2M	CHEBI:29256	2	Chemical	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	The cysteine_sulfhydryl groups of alpha_2-macroglobulin -LRB- alpha_2M -RRB- generated upon thrombin complex formation are in contact with the proteinase surface as evidenced by singlet -- singlet energy transfer measurements from N - -LRB- iodoacetylaminoethyl -RRB- -5 - naphthylamine-1-sulfonic_acid-labeled thiol functions of alpha_2M to fluorescein_isothiocyanate-labeled thrombin .
3593594	0	thiol	37,42	aminopeptidase	43,57	thiol	aminopeptidase	CHEBI:29256	10404	Chemical	Gene	Purification|nmod|START_ENTITY END_ENTITY|nsubj|Purification	Purification and characterization of thiol aminopeptidase from the cytosolic fraction of human placenta .
12033454	0	thiol	13,18	carbonic_anhydrase_III	32,54	thiol	carbonic anhydrase III	CHEBI:29256	54232(Tax:10116)	Chemical	Gene	oxidation|amod|START_ENTITY oxidation|nmod|END_ENTITY	Irreversible thiol oxidation in carbonic_anhydrase_III : protection by S-glutathiolation and detection in aging rats .
11917294	0	thiol	115,120	nuclear_transcription_factor_kappaB	27,62	thiol	nuclear transcription factor kappaB	CHEBI:29256	4790	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Differential activation of nuclear_transcription_factor_kappaB , gene expression , and proteins by amifostine 's free thiol in human microvascular endothelial and glioma cells .
26823067	0	thiol	32,37	peroxiredoxin_1_and_6	54,75	thiol	peroxiredoxin 1 and 6	CHEBI:29256	117254;94167	Chemical	Gene	status|amod|START_ENTITY status|nmod|END_ENTITY	In vivo oxidative stress alters thiol redox status of peroxiredoxin_1_and_6 and impairs rat sperm quality .
2031724	0	thiol	19,24	proteinase	25,35	thiol	proteinase	CHEBI:29256	100616101	Chemical	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	Immunodetection of thiol proteinase levels in various populations of Artemia cysts and during development .
2468345	0	thiol_ester	65,76	alpha_2-macroglobulin	43,64	thiol ester	alpha 2-macroglobulin	CHEBI:51277	2	Chemical	Gene	sites|compound|START_ENTITY sites|amod|END_ENTITY	Electron microscopical localization of the alpha_2-macroglobulin thiol_ester sites .
22197896	0	thiolactone	21,32	plasmin	40,47	thiolactone	plasmin	CHEBI:60317	5340	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Homocysteine and its thiolactone impair plasmin activity induced by urokinase or streptokinase in vitro .
19086271	0	thiolate	109,117	DHR51	0,5	thiolate	DHR51	CHEBI:50539	36702(Tax:7227)	Chemical	Gene	protein|amod|START_ENTITY protein|nsubj|END_ENTITY	DHR51 , the Drosophila_melanogaster homologue of the human photoreceptor_cell-specific_nuclear_receptor , is a thiolate heme-binding protein .
20079424	0	thiols	52,58	CTNS	14,18	thiols	CTNS	MESH:D013438	1497	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|expression expression|compound|END_ENTITY	Modulation of CTNS gene expression by intracellular thiols .
1558197	0	thiols	22,28	EDRF	43,47	thiols	EDRF	MESH:D013438	51327	Chemical	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	Role of intracellular thiols in release of EDRF from cultured endothelial cells .
11306078	0	thiols	78,84	aldose_reductase	14,30	thiols	aldose reductase	MESH:D013438	616199(Tax:9913)	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|activity activity|amod|END_ENTITY	Modulation of aldose_reductase activity through S-thiolation by physiological thiols .
10384960	0	thiols	59,65	cathepsin_B	14,25	thiols	cathepsin B	MESH:D013438	1508	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|activity activity|amod|END_ENTITY	Regulation of cathepsin_B activity by cysteine and related thiols .
2403372	0	thiols	21,27	cathepsin_D	74,85	thiols	cathepsin D	MESH:D013438	1509	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nsubj|effect	Inhibitory effect of thiols on the degradation of albumin by human spleen cathepsin_D .
16088041	0	thiols	11,17	gamma-glutamyl-transpeptidase	93,122	thiols	gamma-glutamyl-transpeptidase	MESH:D013438	116568(Tax:10116)	Chemical	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Nonprotein thiols and disulfides in rat epididymal spermatozoa and epididymal fluid : role of gamma-glutamyl-transpeptidase in sperm maturation .
2886637	0	thiols	109,115	gamma-glutamyltranspeptidase	24,52	thiols	gamma-glutamyltranspeptidase	MESH:D013438	116568(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of inhibition of gamma-glutamyltranspeptidase on biliary and urinary excretion of glutathione-derived thiols and methylmercury .
10403526	0	thiols	44,50	glyceraldehyde-3-phosphate_dehydrogenase	74,114	thiols	glyceraldehyde-3-phosphate dehydrogenase	MESH:D013438	2597	Chemical	Gene	START_ENTITY|nmod|inactivation inactivation|nmod|END_ENTITY	Critical role of sulfenic_acid formation of thiols in the inactivation of glyceraldehyde-3-phosphate_dehydrogenase by nitric_oxide .
2673805	0	thiols	14,20	insulin	25,32	thiols	insulin	MESH:D013438	3630	Chemical	Gene	impact|nmod|START_ENTITY impact|nmod|secretion secretion|compound|END_ENTITY	The impact of thiols for insulin secretion .
34612	0	thiols	36,42	lactoperoxidase	15,30	thiols	lactoperoxidase	MESH:D013438	4025	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of lactoperoxidase with thiols and diiodotyrosine .
6358411	0	thiols	49,55	luteinizing_hormone_releasing_hormone	92,129	thiols	luteinizing hormone releasing hormone	MESH:D013438	25194(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A possible role for copper-mediated oxidation of thiols in the regulation of the release of luteinizing_hormone_releasing_hormone from isolated hypothalamic granules .
8420937	0	thiols	26,32	phosphoenolpyruvate_carboxykinase	36,69	thiols	phosphoenolpyruvate carboxykinase	MESH:D013438	362282(Tax:10116)	Chemical	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of vicinal thiols of phosphoenolpyruvate_carboxykinase -LRB- GTP -RRB- .
8123409	0	thiopentone	30,41	myoglobin	67,76	thiopentone	myoglobin	MESH:D013874	4151	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of different doses of thiopentone on the increase in serum myoglobin induced by suxamethonium in children .
15219768	0	thioperamide	26,38	H3R	8,11	thioperamide	H3R	MESH:C052075	85268(Tax:10116)	Chemical	Gene	activation|nmod|START_ENTITY END_ENTITY|acl|activation	Central H3R activation by thioperamide does not affect energy balance .
22119475	0	thiophene	6,15	MEK	31,34	thiophene	MEK	CHEBI:30856	5609	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	Fused thiophene derivatives as MEK inhibitors .
17336064	0	thiophene	29,38	PTP1B	39,44	thiophene	PTP1B	CHEBI:30856	5770	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Probing acid replacements of thiophene PTP1B inhibitors .
21185721	0	thiophene	21,30	S6K	60,63	thiophene	S6K	CHEBI:30856	6198	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Potent and selective thiophene urea-templated inhibitors of S6K .
21458276	0	thiophene-3-carboxamide	66,89	c-Jun_N-terminal_kinase	128,151	thiophene-3-carboxamide	c-Jun N-terminal kinase	null	5599	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|inhibitors inhibitors|nmod|END_ENTITY	Design , synthesis , and structure-activity relationship studies of thiophene-3-carboxamide derivatives as dual inhibitors of the c-Jun_N-terminal_kinase .
12109112	0	thiophene_gamma-lactams	10,33	serine_protease	51,66	thiophene gamma-lactams	serine protease	null	2147	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|amod|END_ENTITY	5,5-Fused thiophene_gamma-lactams as templates for serine_protease inhibition .
11378359	0	thiopheneamidine	63,79	urokinase_plasminogen_activator	80,111	thiopheneamidine	urokinase plasminogen activator	null	5328	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Structure-based design , synthesis and SAR of a novel series of thiopheneamidine urokinase_plasminogen_activator inhibitors .
15125939	0	thiophenecarboxamide	61,81	IKK-2	82,87	thiophenecarboxamide	IKK-2	null	3551	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Hit-to-lead studies : the discovery of potent , orally active , thiophenecarboxamide IKK-2 inhibitors .
16806920	0	thiophenes	11,21	protein_tyrosine_phosphatase_1B	25,56	thiophenes	protein tyrosine phosphatase 1B	MESH:D013876	5770	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Monocyclic thiophenes as protein_tyrosine_phosphatase_1B inhibitors : capturing interactions with Asp48 .
26269086	0	thiophosphate	39,52	sulfatase	95,104	thiophosphate	sulfatase	MESH:C035638	347527	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Synthesis and biological evaluation of thiophosphate tricyclic coumarin derivatives as steroid sulfatase inhibitors .
2043629	0	thiophosphatidylcholines	60,84	Cholesterol_esterase	0,20	thiophosphatidylcholines	Cholesterol esterase	null	1056	Chemical	Gene	hydrolysis|nmod|START_ENTITY hydrolysis|amod|END_ENTITY	Cholesterol_esterase catalyzed hydrolysis of mixed micellar thiophosphatidylcholines : a possible charge-relay mechanism .
25605455	0	thiopurine	24,34	thiopurine_S-methyltransferase	44,74	thiopurine	thiopurine S-methyltransferase	CHEBI:35666	7172	Chemical	Gene	therapy|amod|START_ENTITY therapy|amod|END_ENTITY	Getting the best out of thiopurine therapy : thiopurine_S-methyltransferase and beyond .
16530731	0	thiopurines	152,163	concentrative_nucleoside_transporter_3	19,57	thiopurines	concentrative nucleoside transporter 3	CHEBI:35666	64078	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of the concentrative_nucleoside_transporter_3 and equilibrative_nucleoside_transporter_2 in the resistance of T-lymphoblastic cell lines to thiopurines .
18758113	0	thioquinapiperifil	62,80	phosphodiesterase-5	31,50	thioquinapiperifil	phosphodiesterase-5	MESH:C532289	8654	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Determination of a new type of phosphodiesterase-5 inhibitor , thioquinapiperifil , in a dietary supplement promoted for sexual enhancement .
17937623	0	thioredoxin	22,33	Txnrd1	56,62	thioredoxin	Txnrd1	CHEBI:15967	50493(Tax:10090)	Chemical	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Effect of selenium on thioredoxin reductase activity in Txnrd1 or Txnrd2 hemizygous mice .
11802093	0	thioridazine	10,22	CYP2D6	113,119	thioridazine	CYP2D6	MESH:D013881	1565	Chemical	Gene	dosage|amod|START_ENTITY Effect|nmod|dosage phenotype|nsubj|Effect phenotype|nmod|genotypes genotypes|compound|END_ENTITY	Effect of thioridazine dosage on the debrisoquine hydroxylation phenotype in psychiatric patients with different CYP2D6 genotypes .
12503836	0	thioridazine	97,109	CYP2D6	39,45	thioridazine	CYP2D6	MESH:D013881	1565	Chemical	Gene	capacity|nmod|START_ENTITY capacity|compound|END_ENTITY	QTc interval lengthening is related to CYP2D6 hydroxylation capacity and plasma concentration of thioridazine in patients .
19604081	0	thioridazine	46,58	CYP2D6	13,19	thioridazine	CYP2D6	MESH:D013881	1565	Chemical	Gene	Relevance|nmod|START_ENTITY Relevance|nmod|polymorphism polymorphism|compound|END_ENTITY	Relevance of CYP2D6 -1584 C > G polymorphism for thioridazine : mesoridazine plasma concentration ratio in psychiatric patients .
9352572	0	thioridazine	11,23	CYP2D6	41,47	thioridazine	CYP2D6	MESH:D013881	1565	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|inhibitor inhibitor|nmod|END_ENTITY	Effects of thioridazine , an inhibitor of CYP2D6 , on the steady-state plasma concentrations of the enantiomers of mianserin and its active metabolite , desmethylmianserin , in depressed Japanese patients .
849673	0	thioridazine	63,75	Prolactin	0,9	thioridazine	Prolactin	MESH:D013881	5617	Chemical	Gene	doses|nmod|START_ENTITY measures|nmod|doses measures|nsubj|END_ENTITY	Prolactin and psychophysiologic measures after single doses of thioridazine .
17056009	0	thioridazine	51,63	hERG	0,4	thioridazine	hERG	MESH:D013881	2078	Chemical	Gene	blockade|nmod|START_ENTITY blockade|amod|END_ENTITY	hERG K + channel blockade by the antipsychotic drug thioridazine : An obligatory role for the S6 helix residue F656 .
24417241	0	thioridazine	51,63	hERG	73,77	thioridazine	hERG	MESH:D013881	2078	Chemical	Gene	block|amod|START_ENTITY block|nmod|channels channels|amod|END_ENTITY	Allosteric effects of erythromycin pretreatment on thioridazine block of hERG potassium channels .
6932868	0	thioridazine	14,26	prolactin	30,39	thioridazine	prolactin	MESH:D013881	5617	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	The effect of thioridazine on prolactin levels in acutely schizophrenic patients : challenge-dose and steady-state levels .
3301556	0	thiorphan	28,37	Enkephalinase	0,13	thiorphan	Enkephalinase	MESH:D015244	17380(Tax:10090)	Chemical	Gene	response|compound|START_ENTITY inhibition|nmod|response inhibition|nsubj|END_ENTITY	Enkephalinase inhibition by thiorphan and subsequent response of ethanol , normorphine and enkephalins on mouse vas deferens .
6360696	0	thiorphan	32,41	Enkephalinase	0,13	thiorphan	Enkephalinase	MESH:D015244	24590(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Enkephalinase ` A ' inhibition by thiorphan : central and peripheral cardiovascular effects .
3479550	0	thiorphan	15,24	enkephalinase	61,74	thiorphan	enkephalinase	MESH:D015244	24590(Tax:10116)	Chemical	Gene	Enantiomers|nmod|START_ENTITY Enantiomers|dep|correlation correlation|nmod|inhibition inhibition|amod|END_ENTITY	Enantiomers of thiorphan and acetorphan : correlation between enkephalinase inhibition , protection of endogenous enkephalins and behavioral effects .
3910797	0	thiorphan	49,58	enkephalinase	21,34	thiorphan	enkephalinase	MESH:D015244	24590(Tax:10116)	Chemical	Gene	Relationship|nmod|START_ENTITY Relationship|nmod|inhibition inhibition|amod|END_ENTITY	Relationship between enkephalinase inhibition of thiorphan in vivo and its analgesic activity .
6383841	0	thiorphan	54,63	enkephalinase	68,81	thiorphan	enkephalinase	MESH:D015244	24590(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Potentiation of the hypoglycemic effect of insulin by thiorphan , an enkephalinase inhibitor .
6586195	0	thiorphan	64,73	enkephalinase	39,52	thiorphan	enkephalinase	MESH:D015244	24590(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Endogenous opiate reward induced by an enkephalinase inhibitor , thiorphan , injected into the ventral midbrain .
11226883	0	thiorphan	82,91	matrix_metalloproteinase_7	22,48	thiorphan	matrix metalloproteinase 7	MESH:D015244	4316	Chemical	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of human matrix_metalloproteinase_7 -LRB- matrilysin -RRB- with the inhibitors thiorphan and R-94138 .
1317691	0	thiorphan	58,67	neutral_endopeptidase	25,46	thiorphan	neutral endopeptidase	MESH:D015244	4311	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	The effect of an inhaled neutral_endopeptidase inhibitor , thiorphan , on airway responses to neurokinin_A in normal humans in vivo .
24138103	0	thiorphan	151,160	neutral_endopeptidase	11,32	thiorphan	neutral endopeptidase	MESH:D015244	4311	Chemical	Gene	studies|nmod|START_ENTITY Effects|dep|studies Effects|nmod|inhibition inhibition|amod|END_ENTITY	Effects of neutral_endopeptidase -LRB- neprilysin -RRB- inhibition on the response to other vasoactive peptides in small human resistance arteries : studies with thiorphan and omapatrilat .
26686468	0	thiosemicarbazones	76,94	thioredoxin_reductase	113,134	thiosemicarbazones	thioredoxin reductase	MESH:D013882	25824	Chemical	Gene	use|nmod|START_ENTITY use|nmod|END_ENTITY	Enhanced targeting of mitochondrial peroxide defense by the combined use of thiosemicarbazones and inhibitors of thioredoxin_reductase .
21860463	0	thiostrepton	75,87	FOXM1	25,30	thiostrepton	FOXM1	MESH:D013883	2305	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	The transcription factor FOXM1 is a cellular target of the natural product thiostrepton .
22761781	0	thiostrepton	47,59	Peroxiredoxin_3	0,15	thiostrepton	Peroxiredoxin 3	MESH:D013883	10935	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Peroxiredoxin_3 is a redox-dependent target of thiostrepton in malignant_mesothelioma cells .
18552404	0	thiosulfinate	41,54	sulfiredoxin	117,129	thiosulfinate	sulfiredoxin	null	853776(Tax:4932)	Chemical	Gene	START_ENTITY|nmod|mechanism mechanism|nmod|END_ENTITY	Evidence for the formation of a covalent thiosulfinate intermediate with peroxiredoxin in the catalytic mechanism of sulfiredoxin .
1634926	0	thiotepa	17,25	granulocyte-macrophage_colony-stimulating_factor	64,112	thiotepa	granulocyte-macrophage colony-stimulating factor	MESH:D013852	1437	Chemical	Gene	trial|nmod|START_ENTITY trial|nmod|END_ENTITY	Phase I trial of thiotepa in combination with recombinant human granulocyte-macrophage_colony-stimulating_factor .
25413270	0	thiotetrazolates	8,24	thioredoxin_reductase	28,49	thiotetrazolates	thioredoxin reductase	null	25824	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Gold -LRB- i -RRB- thiotetrazolates as thioredoxin_reductase inhibitors and antiproliferative agents .
7790147	0	thioureylenes	42,55	PCNA	59,63	thioureylenes	PCNA	null	5111	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of orally administered antithyroid thioureylenes on PCNA and P53 expression in psoriatic_lesions .
17191286	0	thioxothiazolidinone	68,88	protein_tyrosine_phosphatase_1B	23,54	thioxothiazolidinone	protein tyrosine phosphatase 1B	null	5770	Chemical	Gene	derivatives|compound|START_ENTITY inhibition|nmod|derivatives inhibition|nmod|END_ENTITY	Cellular inhibition of protein_tyrosine_phosphatase_1B by uncharged thioxothiazolidinone derivatives .
15078988	0	threonine	19,28	Aurora-2	37,45	threonine	Aurora-2	CHEBI:26986	6790	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	The mitotic serine threonine kinase , Aurora-2 , is a potential target for drug development in human pancreatic_cancer .
23088644	0	threonine	142,151	Bcr-Abl	109,116	threonine	Bcr-Abl	CHEBI:26986	25	Chemical	Gene	inhibitors|nmod|START_ENTITY inhibitors|nsubj|END_ENTITY	Design , synthesis , and biological evaluation of 3 - -LRB- 1H-1 ,2,3 - triazol-1-yl -RRB- benzamide derivatives as Potent Pan Bcr-Abl inhibitors including the threonine -LRB- 315 -RRB- > isoleucine -LRB- 315 -RRB- mutant .
7636185	0	threonine	43,52	CD18	72,76	threonine	CD18	CHEBI:26986	3689	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Treatment with okadaic_acid reveals strong threonine phosphorylation of CD18 after activation of CD11/CD18 leukocyte integrins with phorbol_esters or CD3 antibodies .
21098020	0	threonine	73,82	CDK9	68,72	threonine	CDK9	CHEBI:26986	1025	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|compound|END_ENTITY	Expression of a protein_phosphatase_1 inhibitor , cdNIPP1 , increases CDK9 threonine 186 phosphorylation and inhibits HIV-1 transcription .
18243098	0	threonine	21,30	Chk1	0,4	threonine	Chk1	CHEBI:26986	1111	Chemical	Gene	kinase|compound|START_ENTITY kinase|nsubj|END_ENTITY	Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression .
17504756	0	threonine	4,13	Cripto	67,73	threonine	Cripto	CHEBI:26986	21667(Tax:10090)	Chemical	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	The threonine that carries fucose , but not fucose , is required for Cripto to facilitate Nodal signaling .
10816576	4	threonine	644,653	EGFR	681,685	threonine	EGFR	CHEBI:26986	1956	Chemical	Gene	residue|compound|START_ENTITY residue|nmod|END_ENTITY	The inhibitory effects of PKC are mediated by a single threonine residue -LRB- threonine 654 -RRB- of EGFR , which serves as a major PKC phosphorylation site .
11948414	4	threonine	683,692	ETS1	707,711	threonine	JNK1	CHEBI:26986	5599	Chemical	Gene	residue|amod|START_ENTITY residue|nmod|END_ENTITY	Using in vitro and in vivo kinase assays , we found that HGF/SF activates the ERK1 MAP kinase , leading to the phosphorylation of the threonine 38 residue of ETS1 within a putative MAP kinase phosphorylation site -LRB- PLLT38P -RRB- .
10641038	0	threonine	113,122	GLY1	133,137	threonine	GLY1	CHEBI:26986	856665(Tax:4932)	Chemical	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Glycine metabolism in Candida_albicans : characterization of the serine hydroxymethyltransferase -LRB- SHM1 , SHM2 -RRB- and threonine aldolase -LRB- GLY1 -RRB- genes .
9163906	0	threonine	53,62	GLY1	43,47	threonine	GLY1	CHEBI:26986	856665(Tax:4932)	Chemical	Gene	aldolase|amod|START_ENTITY END_ENTITY|nmod|aldolase	Identification of Saccharomyces_cerevisiae GLY1 as a threonine aldolase : a key enzyme in glycine biosynthesis .
13129919	0	threonine	22,31	Glut1	49,54	threonine	Glut1	CHEBI:26986	6513	Chemical	Gene	mutations|amod|START_ENTITY mutations|nmod|END_ENTITY	Functional studies of threonine 310 mutations in Glut1 : T310I is pathogenic , causing Glut1_deficiency .
21576760	0	threonine	41,50	Hsp90	35,40	threonine	Hsp90	CHEBI:26986	855836(Tax:4932)	Chemical	Gene	function|amod|START_ENTITY function|compound|END_ENTITY	Casein kinase 2 phosphorylation of Hsp90 threonine 22 modulates chaperone function and drug sensitivity .
26106822	0	threonine	100,109	IKKb	130,134	threonine	IKKb	CHEBI:26986	3551	Chemical	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	Detection of huntingtin exon 1 phosphorylation by Phos-Tag SDS-PAGE : Predominant phosphorylation on threonine 3 and regulation by IKKb .
25743155	0	threonine	48,57	IL1403	98,104	threonine	IL1403	CHEBI:26986	3173391(Tax:283942)	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Excess of threonine compared to serine promotes threonine aldolase activity in Lactococcus_lactis IL1403 .
25352548	7	threonine	1123,1132	KSRP	1118,1122	threonine	KSRP	CHEBI:26986	8570	Chemical	Gene	phosphorylation|amod|START_ENTITY END_ENTITY|dobj|phosphorylation	Resveratrol did not change KSRP expression , but immunoprecipitation experiments indicated that resveratrol reduces the p38 MAPK-related inhibitory KSRP threonine phosphorylation , without blocking p38 MAPK activation or activity .
15192708	0	threonine	67,76	LAT	96,99	threonine	LAT	CHEBI:26986	27040	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Negative feedback loop in T-cell activation through MAPK-catalyzed threonine phosphorylation of LAT .
8137910	0	threonine	4,13	MAP_kinase_kinase_1	26,45	threonine	MAP kinase kinase 1	CHEBI:26986	170851(Tax:10116)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	The threonine residues in MAP_kinase_kinase_1 phosphorylated by MAP kinase in vitro are also phosphorylated in nerve growth factor-stimulated rat phaeochromocytoma -LRB- PC12 -RRB- cells .
10338138	0	threonine	56,65	MUC2	78,82	threonine	MUC2	CHEBI:26986	4583	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	Incorporation of N-acetylgalactosamine into consecutive threonine residues in MUC2 tandem repeat by recombinant human N-acetyl-D-galactosamine transferase-T1 , T2 and T3 .
10749684	0	threonine	65,74	MUC2	87,91	threonine	MUC2	CHEBI:26986	4583	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Order and maximum incorporation of N-acetyl-D-galactosamine into threonine residues of MUC2 core peptide with microsome fraction of human-colon-carcinoma LS174T cells .
22250195	0	threonine	59,68	N-WASP	88,94	threonine	N-WASP	CHEBI:26986	8976	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Dyrk1A negatively regulates the actin cytoskeleton through threonine phosphorylation of N-WASP .
7532398	0	threonine	88,97	PC-1	31,35	threonine	PC-1	CHEBI:26986	85496(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY Regulation|nmod|phosphorylation Regulation|nmod|END_ENTITY	Regulation of purified hepatic PC-1 -LRB- phosphodiesterase-I/nucleotide _ pyrophosphatase -RRB- by threonine auto -LRB- de -RRB- phosphorylation and by binding of acidic_fibroblast_growth_factor .
26321373	0	threonine	91,100	PKR	87,90	threonine	PKR	CHEBI:26986	5610	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Insulin treatment promotes tyrosine phosphorylation of PKR and inhibits polyIC induced PKR threonine phosphorylation .
21737676	0	threonine	23,32	RelA	12,16	threonine	RelA	CHEBI:26986	19697(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	The role of RelA -LRB- p65 -RRB- threonine 505 phosphorylation in the regulation of cell growth , survival , and migration .
25168378	0	threonine	50,59	Smad2/3	19,26	threonine	Smad2/3	CHEBI:26986	17126;17127	Chemical	Gene	residue|compound|START_ENTITY END_ENTITY|nmod|residue	Phosphorylation of Smad2/3 at the specific linker threonine residue indicates slow-cycling esophageal stem-like cells before re-entry to the cell cycle .
16105842	6	threonine	899,908	Sp1	928,931	threonine	p27	CHEBI:26986	3429	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Inhibition of the Ras-MEK-ERK cascade by Gal-1 increased Sp1 transactivation and DNA binding due to reduced threonine phosphorylation of Sp1 .
23616576	0	threonine	85,94	T-bet	114,119	threonine	T-bet	CHEBI:26986	30009	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Lysine 313 of T-box is crucial for modulation of protein stability , DNA binding , and threonine phosphorylation of T-bet .
9407095	0	threonine	30,39	Tiam1	59,64	threonine	Tiam1	CHEBI:26986	7074	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Lysophosphatidic_acid induces threonine phosphorylation of Tiam1 in Swiss 3T3 fibroblasts via activation of protein kinase C .
22511927	0	threonine	31,40	beta-catenin	78,90	threonine	beta-catenin	CHEBI:26986	1499	Chemical	Gene	generation|amod|START_ENTITY generation|nmod|END_ENTITY	Beta-catenin phosphorylated at threonine 120 antagonizes generation of active beta-catenin by spatial localization in trans-Golgi_network .
14502569	0	threonine	40,49	beta1_integrin	69,83	threonine	beta1 integrin	CHEBI:26986	3688	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Reduced cell adhesion during mitosis by threonine phosphorylation of beta1_integrin .
2548197	0	threonine	48,57	epidermal_growth_factor	70,93	threonine	epidermal growth factor	CHEBI:26986	1950	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Stimulation of phosphorylation of lipocortin at threonine residues by epidermal_growth_factor -LRB- EGF -RRB- and the EGF_receptor : addition of protein kinase P with polylysine inhibits this effect .
6091636	0	threonine	22,31	epidermal_growth_factor_receptor	61,93	threonine	epidermal growth factor receptor	CHEBI:26986	1956	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Phorbol_ester-induced threonine phosphorylation of the human epidermal_growth_factor_receptor occurs within the EGF binding domain .
2507541	0	threonine	133,142	hsp90_alpha	101,112	threonine	hsp90 alpha	CHEBI:26986	3320	Chemical	Gene	residues|amod|START_ENTITY END_ENTITY|nmod|residues	The human double-stranded DNA-activated protein kinase phosphorylates the 90-kDa heat-shock protein , hsp90_alpha at two NH2-terminal threonine residues .
10880530	0	threonine	87,96	interleukin_2	48,61	threonine	interleukin 2	CHEBI:26986	16183(Tax:10090)	Chemical	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Negative regulation of T cell proliferation and interleukin_2 production by the serine threonine kinase GSK-3 .
24359813	0	threonine	37,46	mammalian_target_of_rapamycin	58,87	threonine	mammalian target of rapamycin	CHEBI:26986	2475	Chemical	Gene	effects|amod|START_ENTITY effects|nmod|END_ENTITY	Isoleucine , leucine , methionine , and threonine effects on mammalian_target_of_rapamycin signaling in mammary tissue .
25666762	0	threonine	31,40	non-structural_1	51,67	threonine	non-structural 1	CHEBI:26986	5781	Chemical	Gene	START_ENTITY|nmod|protein protein|amod|END_ENTITY	A monoclonal antibody binds to threonine 49 in the non-structural_1 protein of influenza_A_virus and interferes with its ability to modulate viral replication .
10734067	0	threonine	45,54	p53	41,44	threonine	p53	CHEBI:26986	7157	Chemical	Gene	START_ENTITY|nsubj|phosphorylation phosphorylation|nmod|END_ENTITY	Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase .
25485500	0	threonine	4,13	p63	0,3	threonine	p63	CHEBI:26986	8626	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	p63 threonine phosphorylation signals the interaction with the WW domain of the E3 ligase Itch .
10581004	0	threonine	58,67	paxillin	20,28	threonine	paxillin	CHEBI:26986	360820(Tax:10116)	Chemical	Gene	kinases|amod|START_ENTITY kinases|amod|END_ENTITY	Characterization of paxillin LIM domain-associated serine threonine kinases : activation by angiotensin_II in vascular smooth muscle cells .
6915934	0	threonine	35,44	tRNA	45,49	threonine	tRNA	CHEBI:26986	2715669(Tax:3562)	Chemical	Gene	START_ENTITY|dobj|gene gene|compound|END_ENTITY	Structure of a spinach chloroplast threonine tRNA gene .
22574111	0	threonine	4,13	testes-specific_protease_50	35,62	threonine	testes-specific protease 50	CHEBI:26986	235631(Tax:10090)	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	The threonine protease activity of testes-specific_protease_50 -LRB- TSP50 -RRB- is essential for its function in cell proliferation .
1421756	0	threonine	42,51	transferrin_receptor	73,93	threonine	transferrin receptor	CHEBI:26986	7037	Chemical	Gene	residue|amod|START_ENTITY residue|nmod|END_ENTITY	Presence of O-linked oligosaccharide on a threonine residue in the human transferrin_receptor .
16824760	0	thrombin	18,26	PAR-1	37,42	thrombin	PAR-1	MESH:D013917	2149	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|appos|END_ENTITY	Himbacine derived thrombin receptor -LRB- PAR-1 -RRB- antagonists : structure-activity relationship of the lactone ring .
17574850	0	thrombin	18,26	PAR-1	37,42	thrombin	PAR-1	MESH:D013917	2149	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|appos|END_ENTITY	Himbacine derived thrombin receptor -LRB- PAR-1 -RRB- antagonists : SAR of the pyridine ring .
6818711	0	thromboplastin	66,80	phospholipase_C	19,34	thromboplastin	phospholipase C	MESH:D013925	100009319(Tax:9986)	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|END_ENTITY	In vitro effect of phospholipase_C from Bacillus_cereus on tissue thromboplastin from different species .
12495897	0	thrombopoietin	34,48	B1647	93,98	thrombopoietin	B1647	MESH:D013926	946960(Tax:511145)	Chemical	Gene	stimulation|compound|START_ENTITY stimulation|nmod|END_ENTITY	Lyn kinase is activated following thrombopoietin stimulation of the megakaryocytic cell line B1647 .
7795229	0	thrombopoietin	12,26	Janus_kinase_2	77,91	thrombopoietin	Janus kinase 2	MESH:D013926	3717	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Recombinant thrombopoietin induces rapid protein tyrosine phosphorylation of Janus_kinase_2 and Shc in human blood platelets .
26450985	0	thrombopoietin	21,35	MPL	46,49	thrombopoietin	MPL	MESH:D013926	4352	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Presence of atypical thrombopoietin receptor -LRB- MPL -RRB- mutations in triple negative essential thrombocythemia patients .
8695859	0	thrombopoietin	43,57	MPL	67,70	thrombopoietin	MPL	MESH:D013926	17480(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY form|nmod|receptor Identification|nmod|form END_ENTITY|nsubj|Identification	Identification of an oncogenic form of the thrombopoietin receptor MPL using retrovirus-mediated gene transfer .
8943846	0	thrombopoietin	8,22	Mpl	33,36	thrombopoietin	Mpl	MESH:D013926	17480(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Soluble thrombopoietin receptor -LRB- Mpl -RRB- and granulocyte_colony-stimulating_factor_receptor directly stimulate proliferation of primitive hematopoietic progenitors of mice in synergy with steel_factor or the ligand for Flt3/Flk2 .
9122198	0	thrombopoietin	15,29	Mpl	67,70	thrombopoietin	Mpl	MESH:D013926	17480(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY Dissecting|dobj|receptor Dissecting|dep|elements elements|nmod|domain domain|compound|END_ENTITY	Dissecting the thrombopoietin receptor : functional elements of the Mpl cytoplasmic domain .
11961237	1	thrombopoietin	172,186	TPO	188,191	thrombopoietin	TPO	MESH:D013926	7066	Chemical	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	BACKGROUND : Data from several studies support the hypothesis that thrombopoietin -LRB- TPO -RRB- plasma levels are regulated via circulating platelet -LRB- PLT -RRB- numbers by binding to PLT TPO receptors -LRB- TPO-Rs -RRB- .
22808089	0	thrombospondin	36,50	CD36	30,34	thrombospondin	CD36	null	12491(Tax:10090)	Chemical	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	Context dependent role of the CD36 -- thrombospondin -- histidine-rich glycoprotein_axis in tumor angiogenesis and growth .
8382699	0	thrombospondins	125,140	Corticotropin-induced_secreted_protein	0,38	thrombospondins	Corticotropin-induced secreted protein	null	338092(Tax:9913)	Chemical	Gene	related|nmod|START_ENTITY related|nsubjpass|END_ENTITY	Corticotropin-induced_secreted_protein , an ACTH-induced protein secreted by adrenocortical cells , is structurally related to thrombospondins .
19114962	0	thromboxane	51,62	CYP5A1	73,79	thromboxane	CYP5A1	CHEBI:26995	6916	Chemical	Gene	synthase|amod|START_ENTITY gene|amod|synthase gene|appos|END_ENTITY	The effect of an exon 12 polymorphism of the human thromboxane synthase -LRB- CYP5A1 -RRB- gene in stroke patients .
2055246	0	thromboxane	2,13	DP-1904	37,44	thromboxane	DP-1904	CHEBI:26995	2944390(Tax:177439)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	A thromboxane A2 synthase inhibitor , DP-1904 , prevents rat renal_injury .
9179617	0	thromboxane	8,19	DP-1904	42,49	thromboxane	DP-1904	CHEBI:26995	2944390(Tax:177439)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	A novel thromboxane synthetase inhibitor , DP-1904 , inhibits human blood eosinophil degranulation .
9438218	0	thromboxane	29,40	IGF-I	10,15	thromboxane	IGF-I	CHEBI:26995	3479	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of IGF-I on placental thromboxane and prostacyclin release in severe intrauterine_growth_retardation .
14565864	0	thromboxane	15,26	Nrf2	0,4	thromboxane	Nrf2	CHEBI:26995	4780	Chemical	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Nrf2 regulates thromboxane synthase gene expression in human lung cells .
1483486	0	thromboxane	44,55	S-1452	34,40	thromboxane	S-1452	CHEBI:26995	1077823(Tax:198215)	Chemical	Gene	antagonist|amod|START_ENTITY END_ENTITY|appos|antagonist	Effect of treatment at night with S-1452 , a thromboxane A2 receptor antagonist , on the morning_rise in platelet_aggregation .
1533111	0	thromboxane	41,52	S-1452	22,28	thromboxane	S-1452	CHEBI:26995	1077823(Tax:198215)	Chemical	Gene	receptor|amod|START_ENTITY END_ENTITY|appos|receptor	-LSB- Inhibitory effect of S-1452 , a specific thromboxane A2 receptor antagonist on the increase of airway responsiveness in dogs after ozone exposure -RSB- .
7653751	0	thromboxane	39,50	S-1452	72,78	thromboxane	S-1452	CHEBI:26995	1077823(Tax:198215)	Chemical	Gene	antagonist|amod|START_ENTITY administration|nmod|antagonist Effects|nmod|administration Effects|appos|END_ENTITY	Effects of aerosol administration of a thromboxane receptor antagonist -LRB- S-1452 -RRB- on experimental asthma in guinea_pigs .
7899476	0	thromboxane	28,39	S-1452	61,67	thromboxane	S-1452	CHEBI:26995	1077823(Tax:198215)	Chemical	Gene	receptor|amod|START_ENTITY effect|nmod|receptor effect|amod|END_ENTITY	Antiproteinuric effect of a thromboxane receptor antagonist , S-1452 , on rat diabetic_nephropathy and murine lupus_nephritis .
2484709	0	thromboxane	32,43	SIN-1	23,28	thromboxane	SIN-1	CHEBI:26995	79109	Chemical	Gene	formation|compound|START_ENTITY effect|nmod|formation effect|nmod|END_ENTITY	Differential effect of SIN-1 on thromboxane and prostacyclin formation in platelets and endothelial cells .
8702673	0	thromboxane	66,77	Sp1	15,18	thromboxane	Sp1	CHEBI:26995	6667	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	Novel role for Sp1 in phorbol_ester enhancement of human platelet thromboxane receptor gene expression .
113526	0	thromboxane	23,34	Vasopressin	0,11	thromboxane	Vasopressin	CHEBI:26995	551	Chemical	Gene	synthesis|amod|START_ENTITY stimulates|dobj|synthesis stimulates|nsubj|END_ENTITY	Vasopressin stimulates thromboxane synthesis in the toad urinary bladder : effects of imidazole .
6419286	0	thromboxane	23,34	Vasopressin	0,11	thromboxane	Vasopressin	CHEBI:26995	551	Chemical	Gene	synthesis|amod|START_ENTITY stimulates|dobj|synthesis stimulates|nsubj|END_ENTITY	Vasopressin stimulates thromboxane synthesis in isolated hamster hepatocytes : relation to hepatocyte calcium content .
15655126	0	thromboxane	119,130	cyclooxygenase-2	77,93	thromboxane	cyclooxygenase-2	CHEBI:26995	19225(Tax:10090)	Chemical	Gene	antagonism|amod|START_ENTITY combined|nmod|antagonism inhibition|acl|combined inhibition|amod|END_ENTITY	Cyclooxygenases , thromboxane , and atherosclerosis : plaque destabilization by cyclooxygenase-2 inhibition combined with thromboxane receptor antagonism .
17632087	0	thromboxane	14,25	cyclooxygenase-2	63,79	thromboxane	cyclooxygenase-2	CHEBI:26995	5743	Chemical	Gene	alpha|amod|START_ENTITY Activation|nmod|alpha induces|nsubj|Activation induces|dobj|expression expression|nmod|cells cells|amod|END_ENTITY	Activation of thromboxane receptor alpha induces expression of cyclooxygenase-2 through multiple signaling pathways in A549 human lung_adenocarcinoma cells .
19107625	0	thromboxane	91,102	cyclooxygenase-2	73,89	thromboxane	cyclooxygenase-2	CHEBI:26995	5743	Chemical	Gene	synthase|amod|START_ENTITY synthase|amod|END_ENTITY	Chlorella powder inhibits the activities of peptidase cathepsin S , PLA2 , cyclooxygenase-2 , thromboxane synthase , tyrosine phosphatases , tumor necrosis factor-alpha converting enzyme , calpain and kinases .
19766029	0	thromboxane	131,142	cyclooxygenase-2	99,115	thromboxane	cyclooxygenase-2	CHEBI:26995	5743	Chemical	Gene	synthase|dep|START_ENTITY synthase|compound|END_ENTITY	Genome wide analysis and comparative docking studies of new diaryl_furan derivatives against human cyclooxygenase-2 , lipoxygenase , thromboxane synthase and prostacyclin synthase enzymes involved in inflammatory pathway .
20924284	0	thromboxane	54,65	cyclooxygenase-2	10,26	thromboxane	cyclooxygenase-2	CHEBI:26995	19225(Tax:10090)	Chemical	Gene	production|compound|START_ENTITY suppresses|dobj|production suppresses|nsubj|inhibitor inhibitor|amod|END_ENTITY	Selective cyclooxygenase-2 inhibitor suppresses renal thromboxane production but not proliferative lesions in the MRL/lpr murine model of lupus_nephritis .
9020023	0	thromboxane	127,138	cyclooxygenase-2	55,71	thromboxane	cyclooxygenase-2	CHEBI:26995	29527(Tax:10116)	Chemical	Gene	macrophages|amod|START_ENTITY prostaglandin_E2|nmod|macrophages production|nmod|prostaglandin_E2 leads|nmod|production leads|nsubj|induction induction|nmod|synthase synthase|nmod|END_ENTITY	Concordant induction of prostaglandin_E2 synthase with cyclooxygenase-2 leads to preferred production of prostaglandin_E2 over thromboxane and prostaglandin_D2 in lipopolysaccharide-stimulated rat peritoneal macrophages .
9657255	0	thromboxane	52,63	cyclooxygenase-2	15,31	thromboxane	cyclooxygenase-2	CHEBI:26995	29527(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY NS-398|nmod|synthesis NS-398|amod|END_ENTITY	Effects of the cyclooxygenase-2 inhibitor NS-398 on thromboxane and leukotriene synthesis in rat peritoneal cells .
2708811	0	thromboxane	49,60	cytochrome_P-450	16,32	thromboxane	cytochrome P-450	CHEBI:26995	25251(Tax:10116)	Chemical	Gene	START_ENTITY|amod|dependent dependent|amod|END_ENTITY	Manipulation of cytochrome_P-450 dependent renal thromboxane synthase activity in spontaneously hypertensive rats .
6762683	0	thromboxane	23,34	insulin	82,89	thromboxane	insulin	CHEBI:26995	3630	Chemical	Gene	START_ENTITY|nmod|therapy therapy|compound|END_ENTITY	Comparison of platelet thromboxane synthesis in diabetic patients on conventional insulin therapy and continuous insulin infusions .
8011980	0	thromboxane	10,21	interleukin-2	60,73	thromboxane	interleukin-2	CHEBI:26995	116562(Tax:10116)	Chemical	Gene	mediates|nsubj|START_ENTITY mediates|dobj|effects effects|nmod|END_ENTITY	Increased thromboxane mediates the adverse renal effects of interleukin-2 in rats .
2955229	0	thromboxane	40,51	lipocortin_1	18,30	thromboxane	lipocortin 1	CHEBI:26995	301	Chemical	Gene	release|amod|START_ENTITY inhibits|dobj|release inhibits|nsubj|END_ENTITY	Recombinant human lipocortin_1 inhibits thromboxane release from guinea-pig isolated perfused lung .
11777901	0	thromboxane	29,40	peroxisome_proliferator-activated_receptor-gamma	58,106	thromboxane	peroxisome proliferator-activated receptor-gamma	CHEBI:26995	5468	Chemical	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Transcription suppression of thromboxane receptor gene by peroxisome_proliferator-activated_receptor-gamma via an interaction with Sp1 in vascular smooth muscle cells .
6419286	6	thromboxane	948,959	vasopressin	925,936	thromboxane	vasopressin	CHEBI:26995	551	Chemical	Gene	START_ENTITY|nsubj|stimulates stimulates|compound|END_ENTITY	These results indicate that vasopressin stimulates thromboxane synthesis in hepatocytes but suggest that thromboxane does not play a role in the vasopressin-induced reduction in 45Ca + + content in this cell type .
26749169	0	thromboxane_A2	96,110	ABCA1	153,158	thromboxane A2	ABCA1	MESH:D013928	11303(Tax:10090)	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	ATP-binding_cassette_transporter_1 -LRB- ABCA1 -RRB- deficiency decreases platelet reactivity and reduces thromboxane_A2 production independently of hematopoietic ABCA1 .
15319801	0	thromboxane_A2	94,108	BK2	0,3	thromboxane A2	BK2	MESH:D013928	624	Chemical	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	BK2 but not BK1 receptors mediating contractile response in human umbilical arteries : role of thromboxane_A2 .
1516634	0	thromboxane_A2	71,85	Endothelin-1	0,12	thromboxane A2	Endothelin-1	MESH:D013928	24323(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY enhances|parataxis|role enhances|nsubj|END_ENTITY	Endothelin-1 enhances vascular permeability in conscious rats : role of thromboxane_A2 .
21636808	0	thromboxane_A2	39,53	NOX2	103,107	thromboxane A2	NOX2	MESH:D013928	1536	Chemical	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Anoxia-reoxygenation enhances platelet thromboxane_A2 production via reactive oxygen species-generated NOX2 : effect in patients undergoing elective percutaneous coronary intervention .
10515420	0	thromboxane_A2	85,99	Phospholipase_A2	0,16	thromboxane A2	Phospholipase A2	MESH:D013928	104974671	Chemical	Gene	augments|nmod|START_ENTITY augments|nsubj|END_ENTITY	Phospholipase_A2 augments contraction and intracellular calcium mobilization through thromboxane_A2 in bovine tracheal smooth muscle .
7686675	0	thromboxane_A2	22,36	S-1452	65,71	thromboxane A2	S-1452	MESH:D013928	1077823(Tax:198215)	Chemical	Gene	antagonist|amod|START_ENTITY antagonist|appos|END_ENTITY	The effect of a novel thromboxane_A2 -LRB- TXA2 -RRB- receptor antagonist -LRB- S-1452 -RRB- on the antigen-induced bronchoconstriction and airway hyperresponsiveness in guinea_pigs .
18295304	0	thromboxane_A2	68,82	cyclooxygenase-2	41,57	thromboxane A2	cyclooxygenase-2	MESH:D013928	5743	Chemical	Gene	production|amod|START_ENTITY production|amod|END_ENTITY	Lack of biological relevance of platelet cyclooxygenase-2 dependent thromboxane_A2 production .
8587337	0	thromboxane_A2	67,81	endothelin-1	27,39	thromboxane A2	endothelin-1	MESH:D013928	100726197	Chemical	Gene	role|nmod|START_ENTITY effects|dep|role effects|nmod|END_ENTITY	Cardiopulmonary effects of endothelin-1 in the guinea_pig : role of thromboxane_A2 .
6577468	0	thromboxane_A2	14,28	factor_Xa	73,82	thromboxane A2	factor Xa	MESH:D013928	2159	Chemical	Gene	synthesis|amod|START_ENTITY Inhibition|nmod|synthesis Inhibition|nmod|END_ENTITY	Inhibition of thromboxane_A2 synthesis in human platelets by coagulation factor_Xa .
6281811	0	thromboxane_A2	32,46	leukotriene_B4	74,88	thromboxane A2	leukotriene B4	MESH:D013928	100135572(Tax:10141)	Chemical	Gene	START_ENTITY|nmod|action action|nmod|END_ENTITY	Evidence for a mediator role of thromboxane_A2 in the myotropic action of leukotriene_B4 -LRB- LTB4 -RRB- on the guinea-pig lung .
9190851	0	thromboxane_A2	151,165	thrombin	97,105	thromboxane A2	thrombin	MESH:D013928	2147	Chemical	Gene	formation|compound|START_ENTITY mediates|dobj|formation mediates|nsubj|END_ENTITY	Interaction of a thrombin inhibitor and a platelet GP_IIb / IIIa antagonist in vivo : evidence that thrombin mediates platelet_aggregation and subsequent thromboxane_A2 formation during coronary thrombolysis .
8977210	0	thromboxane_A2	69,83	tumor_necrosis_factor-alpha	14,41	thromboxane A2	tumor necrosis factor-alpha	MESH:D013928	7124	Chemical	Gene	synthesis|nmod|START_ENTITY synthesis|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of tumor_necrosis_factor-alpha and IL-1_beta synthesis by thromboxane_A2 in nonadherent human monocytes .
7531878	0	thromboxane_B2	72,86	P-selectin	58,68	thromboxane B2	P-selectin	MESH:D013929	6403	Chemical	Gene	synthesis|amod|START_ENTITY END_ENTITY|nmod|synthesis	Polymorphonuclear leukocyte-platelet interaction : role of P-selectin in thromboxane_B2 and leukotriene C4 cooperative synthesis .
8040027	0	thymidine	24,33	Interleukin_1	0,13	thymidine	Interleukin 1	MESH:D013936	3552	Chemical	Gene	START_ENTITY|nsubj|increases increases|amod|END_ENTITY	Interleukin_1 increases thymidine labeling index of normal tissues of mice but not the tumor .
19192647	0	thymidine	12,21	STK1	32,36	thymidine	STK1	MESH:D013936	2322	Chemical	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	Serological thymidine kinase 1 -LRB- STK1 -RRB- indicates an elevated risk for the development of malignant_tumours .
17181158	0	thymidine	52,61	TK-2	70,74	thymidine	TK-2	MESH:D013936	7084	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	N1-substituted thymine derivatives as mitochondrial thymidine kinase -LRB- TK-2 -RRB- inhibitors .
10924519	0	thymidine	61,70	TK1	79,82	thymidine	TK1	MESH:D013936	7083	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	Valine , not methionine , is amino_acid 106 in human cytosolic thymidine kinase -LRB- TK1 -RRB- .
17065087	0	thymidine	40,49	TK1	58,61	thymidine	TK1	MESH:D013936	7083	Chemical	Gene	kinase|compound|START_ENTITY C-terminal|nmod|kinase Effect|nmod|C-terminal Effect|appos|END_ENTITY	Effect of C-terminal of human cytosolic thymidine kinase -LRB- TK1 -RRB- on in vitro stability and enzymatic properties .
8605228	0	thymidine	68,77	TK1	86,89	thymidine	TK1	MESH:D013936	7083	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	Existence of phosphorylated and dephosphorylated forms of cytosolic thymidine kinase -LRB- TK1 -RRB- .
8641139	0	thymidine	33,42	TK1	56,59	thymidine	TK1	MESH:D013936	7083	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	FISH localization of the soluble thymidine kinase gene -LRB- TK1 -RRB- to human 17q25 , a region of chromosomal loss in sporadic breast_tumors .
12765840	0	thymidine	85,94	TK2	103,106	thymidine	TK2	MESH:D013936	7084	Chemical	Gene	deficiency|amod|START_ENTITY deficiency|appos|END_ENTITY	mtDNA depletion myopathy : elucidation of the tissue specificity in the mitochondrial thymidine kinase -LRB- TK2 -RRB- deficiency .
23695887	12	thymidine	1351,1360	TK2	1369,1372	thymidine	TK2	MESH:D013936	7084	Chemical	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	TK1 activity remained unchanged in DCM samples while mitochondrial thymidine kinase -LRB- TK2 -RRB- activity was significantly reduced .
11747607	0	thymidine	60,69	Tax	128,131	thymidine	Tax	MESH:D013936	6900	Chemical	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	Cell-type-specific trans-activation of herpes simplex virus thymidine kinase promoter by the human T-cell_leukemia virus type I Tax protein .
8961264	0	thymidine	103,112	Tk-1	121,125	thymidine	Tk-1	MESH:D013936	21877(Tax:10090)	Chemical	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Glucocorticoid regulation of a transcription factor that binds an initiator-like element in the murine thymidine kinase -LRB- Tk-1 -RRB- promoter .
26432886	0	thymidine	37,46	arylformamidase	8,23	thymidine	arylformamidase	MESH:D013936	71562(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Loss of arylformamidase with reduced thymidine kinase expression leads to impaired_glucose_tolerance .
16024770	0	thymidine	83,92	hnRNP_L	11,18	thymidine	hnRNP L	MESH:D013936	3191	Chemical	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Binding of hnRNP_L to the pre-mRNA processing enhancer of the herpes simplex virus thymidine kinase gene enhances both polyadenylation and nucleocytoplasmic export of intronless mRNAs .
1769008	0	thymidine	65,74	insulin_receptor	10,26	thymidine	insulin receptor	MESH:D013936	3643	Chemical	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	Effect of insulin_receptor down regulation on insulin-stimulated thymidine incorporation in cultured human fibroblasts and tumor cell lines .
7068769	0	thymidine	81,90	ornithine_decarboxylase	99,122	thymidine	ornithine decarboxylase	MESH:D013936	4953	Chemical	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	A biochemical investigation of the adenovirus-induced G1 to S phase progression : thymidine kinase , ornithine_decarboxylase , and inhibitors of polyamine biosynthesis .
8622883	0	thymidine	37,46	p16	12,15	thymidine	p16	MESH:D013936	1029	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	The role of p16 in the E2F-dependent thymidine kinase regulation .
9765467	0	thymidine	63,72	p27	54,57	thymidine	p27	MESH:D013936	12576(Tax:10090)	Chemical	Gene	kinase|amod|START_ENTITY END_ENTITY|nmod|kinase	Combination gene delivery of the cell cycle inhibitor p27 with thymidine kinase enhances prodrug cytotoxicity .
11205225	0	thymidine	43,52	proliferating_cell_nuclear_antigen	75,109	thymidine	proliferating cell nuclear antigen	MESH:D013936	5111	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|advcl|END_ENTITY	A new cell proliferating marker : cytosolic thymidine kinase as compared to proliferating_cell_nuclear_antigen in patients with colorectal_carcinoma .
6305487	0	thymidine	96,105	protein_kinase	52,66	thymidine	protein kinase	MESH:D013936	53859(Tax:10090)	Chemical	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Kinetics of adenosine_3 ' :5 ' - monophosphate-dependent protein_kinase activation and inhibition of thymidine incorporation into DNA in P1798 lymphosarcoma cells .
18226913	0	thymidine	50,59	ribonuclease_A	77,91	thymidine	ribonuclease A	MESH:D013936	6035	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Exploring the potential of 3 ' - O-carboxy_esters of thymidine as inhibitors of ribonuclease_A and angiogenin .
2004848	0	thymidine	36,45	thymidylate_synthetase	12,34	thymidine	thymidylate synthetase	MESH:D013936	7298	Chemical	Gene	kinase|amod|START_ENTITY kinase|amod|END_ENTITY	Activity of thymidylate_synthetase , thymidine kinase and galactokinase in primary and xenografted human colorectal_cancers in relation to their chromosomal patterns .
3165095	0	thymidine	46,55	tumor_necrosis_factor	15,36	thymidine	tumor necrosis factor	MESH:D013936	7124	Chemical	Gene	START_ENTITY|nsubj|Stimulation Stimulation|nmod|END_ENTITY	Stimulation by tumor_necrosis_factor of HL-60 thymidine salvage pathway metabolism dissociated from proliferation .
11160865	0	thymidylate	52,63	thymidine_kinase	111,127	thymidylate	thymidine kinase	CHEBI:17013	24271467	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Mutation of Gln125_to_Asn selectively abolishes the thymidylate kinase activity of herpes_simplex_virus_type_1 thymidine_kinase .
23574427	0	thymol	37,43	spp	107,110	thymol	spp	MESH:D013943	81502	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nsubj|effects	Antimicrobial effects of vapor phase thymol , modified atmosphere , and their combination against Salmonella spp .
12065147	0	thymoquinone	42,54	5-lipoxygenase	76,90	thymoquinone	5-lipoxygenase	MESH:C003466	25290(Tax:10116)	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|synthesis synthesis|nmod|products products|amod|END_ENTITY	Nigella sativa oil , nigellone and derived thymoquinone inhibit synthesis of 5-lipoxygenase products in polymorphonuclear leukocytes from rats .
15648658	0	thymoquinone	81,93	5-lipoxygenase	14,28	thymoquinone	5-lipoxygenase	MESH:C003466	240	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of 5-lipoxygenase and leukotriene_C4_synthase in human blood cells by thymoquinone .
17186491	0	thymoquinone	95,107	acetylcholinesterase	9,29	thymoquinone	acetylcholinesterase	MESH:C003466	43	Chemical	Gene	START_ENTITY|nmod|properties properties|amod|END_ENTITY	In vitro acetylcholinesterase inhibitory properties of thymol , carvacrol and their derivatives thymoquinone and thymohydroquinone .
20423995	0	thymoquinone	11,23	mucin_4	45,52	thymoquinone	mucin 4	MESH:C003466	4585	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effects of thymoquinone in the expression of mucin_4 in pancreatic_cancer cells : implications for the development of novel cancer therapies .
24933520	0	thymoquinone	77,89	superoxide_dismutase	53,73	thymoquinone	superoxide dismutase	MESH:C003466	6647	Chemical	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	A structural study on the protection of glycation of superoxide_dismutase by thymoquinone .
6607790	0	thymosin	10,18	glucocorticoid_receptor	22,45	thymosin	glucocorticoid receptor	MESH:D013947	2908	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|compound|END_ENTITY	Effect of thymosin on glucocorticoid_receptor activity and glucocorticoid sensitivity of human thymocytes .
7329413	0	thymosin	64,72	terminal_deoxynucleotidyl_transferase	14,51	thymosin	terminal deoxynucleotidyl transferase	MESH:D013947	21673(Tax:10090)	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|activity activity|amod|END_ENTITY	Modulation of terminal_deoxynucleotidyl_transferase activity by thymosin .
1186495	0	thyrocalcitonin	15,30	gastrin	135,142	thyrocalcitonin	gastrin	MESH:D002116	2520	Chemical	Gene	Stimulation|nmod|START_ENTITY secretion|nsubj|Stimulation secretion|parataxis|mediated mediated|nmod|END_ENTITY	Stimulation of thyrocalcitonin secretion by ethanol in patients with medullary_thyroid_carcinoma -- an effect apparently not mediated by gastrin .
837869	0	thyrocalcitonin	89,104	gastrin	15,22	thyrocalcitonin	gastrin	MESH:D002116	445524(Tax:9823)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Stimulation Stimulation|nmod|END_ENTITY	Stimulation of gastrin secretion in the pig by parathyroid_hormone and its inhibition by thyrocalcitonin .
837869	0	thyrocalcitonin	89,104	parathyroid_hormone	47,66	thyrocalcitonin	parathyroid hormone	MESH:D002116	399502(Tax:9823)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nmod|END_ENTITY	Stimulation of gastrin secretion in the pig by parathyroid_hormone and its inhibition by thyrocalcitonin .
9139974	0	thyroid_hormone	35,50	SERCA2	14,20	thyroid hormone	SERCA2	CHEBI:60311	488	Chemical	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Modulation of SERCA2 expression by thyroid_hormone and norepinephrine in cardiocytes : role of contractility .
25211587	0	thyroid_hormone	27,42	Sox3	14,18	thyroid hormone	Sox3	CHEBI:60311	399335(Tax:8355)	Chemical	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Activation of Sox3 gene by thyroid_hormone in the developing adult intestinal stem cell during Xenopus metamorphosis .
20827662	0	thyroid_hormone	29,44	Stanniocalcin_1	0,15	thyroid hormone	Stanniocalcin 1	CHEBI:60311	6781	Chemical	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Stanniocalcin_1 induction by thyroid_hormone depends on thyroid_hormone receptor b and phosphatidylinositol_3-kinase activation .
16606608	0	thyroid_hormone	71,86	Stromelysin-3	49,62	thyroid hormone	Stromelysin-3	CHEBI:60311	379501(Tax:8355)	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Transcriptional regulation of the Xenopus_laevis Stromelysin-3 gene by thyroid_hormone is mediated by a DNA element in the first intron .
24393243	0	thyroid_hormone	7,22	THRb	38,42	thyroid hormone	THRb	CHEBI:60311	7068	Chemical	Gene	beta|compound|START_ENTITY beta|appos|END_ENTITY	A rare thyroid_hormone receptor beta -LRB- THRb -RRB- gene mutation in a 15-year-old girl with thyroid_hormone resistance syndrome : a case report .
17168554	0	thyroid_hormone	33,48	TRalpha	65,72	thyroid hormone	TRalpha	CHEBI:60311	6955	Chemical	Gene	alpha|amod|START_ENTITY alpha|appos|END_ENTITY	Design and characterization of a thyroid_hormone receptor alpha -LRB- TRalpha -RRB- - specific agonist .
17988877	0	thyroid_hormone	20,35	TRalpha	52,59	thyroid hormone	TRalpha	CHEBI:60311	6955	Chemical	Gene	alpha|amod|START_ENTITY alpha|appos|END_ENTITY	Characterization of thyroid_hormone receptor alpha -LRB- TRalpha -RRB- - specific analogs with varying inner - and outer-ring substituents .
12456652	0	thyroid_hormone	56,71	TRalpha1	90,98	thyroid hormone	TRalpha1	CHEBI:60311	21833(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Normal timing of oligodendrocyte development depends on thyroid_hormone receptor alpha 1 -LRB- TRalpha1 -RRB- .
19196836	0	thyroid_hormone	47,62	TSHalpha	23,31	thyroid hormone	TSHalpha	CHEBI:60311	1081	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Negative regulation of TSHalpha target gene by thyroid_hormone involves histone acetylation and corepressor complex dissociation .
10965897	0	thyroid_hormone	24,39	Transthyretin	0,13	thyroid hormone	Transthyretin	CHEBI:60311	22139(Tax:10090)	Chemical	Gene	levels|amod|START_ENTITY regulates|dobj|levels regulates|nsubj|END_ENTITY	Transthyretin regulates thyroid_hormone levels in the choroid plexus , but not in the brain_parenchyma : study in a transthyretin-null mouse model .
20823345	0	thyroid_hormone	11,26	albumin	47,54	thyroid hormone	albumin	CHEBI:60311	213	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|compound|END_ENTITY	Effects of thyroid_hormone on A1C and glycated albumin levels in nondiabetic subjects with overt_hypothyroidism .
21530650	0	thyroid_hormone	14,29	brain-derived_neurotrophic_factor	66,99	thyroid hormone	brain-derived neurotrophic factor	CHEBI:60311	24225(Tax:10116)	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|nmod|END_ENTITY	Developmental thyroid_hormone insufficiency reduces expression of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- in adults but not in neonates .
11352629	0	thyroid_hormone	43,58	cholinephosphotransferase	14,39	thyroid hormone	cholinephosphotransferase	CHEBI:60311	100718704	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of cholinephosphotransferase by thyroid_hormone .
22865369	0	thyroid_hormone	56,71	iodotyrosine_deiodinase	29,52	thyroid hormone	iodotyrosine deiodinase	CHEBI:60311	447152(Tax:8355)	Chemical	Gene	receptor|amod|START_ENTITY END_ENTITY|nmod|receptor	Direct activation of Xenopus iodotyrosine_deiodinase by thyroid_hormone receptor in the remodeling intestine during amphibian metamorphosis .
17289043	0	thyroid_hormones	31,47	transthyretin	14,27	thyroid hormones	transthyretin	MESH:D013963	7276	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of transthyretin by thyroid_hormones in fish .
11949229	0	thyroliberin	52,64	Prolactin	1,10	thyroliberin	Prolactin	MESH:D013973	5617	Chemical	Gene	stimulation|nmod|START_ENTITY stimulation|nsubj|levels levels|compound|END_ENTITY	-LSB- Prolactin levels before and after stimulation with thyroliberin in primary_hypothyroidism -RSB- .
6412497	0	thyroliberin	40,52	Prolactin	0,9	thyroliberin	Prolactin	MESH:D013973	5617	Chemical	Gene	responses|nmod|START_ENTITY responses|compound|END_ENTITY	Prolactin and thyrotrophin responses to thyroliberin -LRB- TRH -RRB- in patients with growth_hormone deficiency : study in 167 patients .
6794025	0	thyroliberin	57,69	Prolactin	1,10	thyroliberin	Prolactin	MESH:D013973	5617	Chemical	Gene	-RSB-|compound|START_ENTITY level|nmod|-RSB- level|nsubj|END_ENTITY	-LSB- Prolactin level in thyroid_diseases and its reaction to thyroliberin -RSB- .
11892801	0	thyroliberin	75,87	prolactin	19,28	thyroliberin	prolactin	MESH:D013973	24683(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY control|dep|effect control|nmod|expression expression|compound|END_ENTITY	Inverse control of prolactin and growth_hormone gene expression : effect of thyroliberin on transcription and RNA stabilization .
3149403	0	thyroliberin	41,53	prolactin	16,25	thyroliberin	prolactin	MESH:D013973	5617	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Stimulation Stimulation|nmod|END_ENTITY	-LSB- Stimulation of prolactin secretion with thyroliberin -LRB- TRH -RRB- .
6776515	0	thyroliberin	11,23	prolactin	31,40	thyroliberin	prolactin	MESH:D013973	5617	Chemical	Gene	START_ENTITY|nmod|level level|compound|END_ENTITY	-LSB- Effect of thyroliberin on the prolactin level in the blood serum of primary hypothyroid patients -RSB- .
204378	0	thyroliberin	11,23	thyrotropin-releasing-hormone	25,54	thyroliberin	thyrotropin-releasing-hormone	MESH:D013973	25569(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|END_ENTITY	-LSB- Effect of thyroliberin -LRB- thyrotropin-releasing-hormone -RRB- on secretion of thyrotropic hormone and prolacting in a monolayer cultrue of rat adenohypophysis -RSB- .
17679913	0	thyroliberin	14,26	vasopressin	30,41	thyroliberin	vasopressin	MESH:D013973	551	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	-LSB- Influence of thyroliberin on vasopressin and oxytocin release from the hypothalamo-neurohypophysial system under in vivo and in vitro conditions -RSB- .
6428117	0	thyrotrophin	9,21	thyrotropin-releasing_hormone	35,64	thyrotrophin	thyrotropin-releasing hormone	MESH:D013972	25569(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY release|nmod|END_ENTITY	In vitro thyrotrophin release with thyrotropin-releasing_hormone and an analogue , DN-1417 .
7893348	0	thyrotrophin-releasing_hormone	41,71	c-fos	13,18	thyrotrophin-releasing hormone	c-fos	null	2353	Chemical	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	Induction of c-fos in pituitary cells by thyrotrophin-releasing_hormone and phorbol_12-myristate_13-acetate depends upon Ca2 + influx .
2513149	0	thyrotrophin-releasing_hormone	89,119	growth_hormone	12,26	thyrotrophin-releasing hormone	growth hormone	null	2688	Chemical	Gene	determinant|nmod|START_ENTITY determinant|nsubj|END_ENTITY	Spontaneous growth_hormone -LRB- GH -RRB- pulsatility is the major determinant of GH release after thyrotrophin-releasing_hormone in adolescent diabetics .
6432628	0	thyrotrophin-releasing_hormone	61,91	growth_hormone	15,29	thyrotrophin-releasing hormone	growth hormone	null	378781(Tax:9031)	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Stimulation Stimulation|nmod|END_ENTITY	Stimulation of growth_hormone secretion in dwarf chickens by thyrotrophin-releasing_hormone -LRB- TRH -RRB- or human pancreatic growth-hormone-releasing factor -LRB- hpGRF -RRB- .
6791427	0	thyrotrophin-releasing_hormone	20,50	growth_hormone	72,86	thyrotrophin-releasing hormone	growth hormone	null	378781(Tax:9031)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|amod|END_ENTITY	Effect of synthetic thyrotrophin-releasing_hormone and its analogues on growth_hormone secretion in the domestic fowl -LRB- Gallus_domesticus -RRB- .
401886	0	thyrotrophin-releasing_hormone	10,40	prolactin	50,59	thyrotrophin-releasing hormone	prolactin	null	5617	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|compound|END_ENTITY	Effect of thyrotrophin-releasing_hormone on serum prolactin levels in men with azoospermia .
8699429	0	thyrotrophin-releasing_hormone	33,63	prolactin	74,83	thyrotrophin-releasing hormone	prolactin	null	5617	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of continuous infusion of thyrotrophin-releasing_hormone on plasma prolactin and on ovarian activity in melatonin-treated ewes .
8828468	0	thyrotropin	41,52	Glucagon-like_peptide-1	0,23	thyrotropin	Glucagon-like peptide-1	MESH:D013972	14526(Tax:10090)	Chemical	Gene	releases|dobj|START_ENTITY releases|nsubj|END_ENTITY	Glucagon-like_peptide-1 -LRB- GLP-1 -RRB- releases thyrotropin -LRB- TSH -RRB- : characterization of binding sites for GLP-1 on alpha-TSH cells .
7279666	0	thyrotropin	10,21	H1_and_H3	47,56	thyrotropin	H1 and H3	MESH:D013972	3009	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of thyrotropin on 32P-labelled histones H1_and_H3 in specific populations of nucleosomes in the thyroid .
7749503	0	thyrotropin	112,123	Insulin-like_growth_factor_I	0,28	thyrotropin	Insulin-like growth factor I	MESH:D013972	3479	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|compound|END_ENTITY	Insulin-like_growth_factor_I messenger ribonucleic acid expression in porcine thyroid follicles is regulated by thyrotropin and iodine .
3081419	0	thyrotropin	62,73	TRH	123,126	thyrotropin	TRH	MESH:D013972	7200	Chemical	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Cardiopulmonary bypass : a low T4 and T3 syndrome with blunted thyrotropin -LRB- TSH -RRB- response to thyrotropin-releasing_hormone -LRB- TRH -RRB- .
6401835	1	thyrotropin	84,95	TSH	97,100	thyrotropin	TRH	MESH:D013972	25569(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Basal thyrotropin -LRB- TSH -RRB- levels in plasma and the TSH response to thyrotropin-releasing_hormone -LRB- TRH -RRB- were inhibited after Leucine-enkephalin -LRB- L-EK -RRB- administration iv in rats .
2434083	0	thyrotropin	33,44	Thyroglobulin	0,13	thyrotropin	Thyroglobulin	MESH:D013972	24826(Tax:10116)	Chemical	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Thyroglobulin gene activation by thyrotropin and cAMP in hormonally depleted FRTL-5 thyroid cells .
8136736	0	thyrotropin	51,62	neuromedin_B	22,34	thyrotropin	neuromedin B	MESH:D013972	499194(Tax:10116)	Chemical	Gene	secretion|compound|START_ENTITY effect|nmod|secretion effect|nmod|END_ENTITY	Paradoxical effect of neuromedin_B and thyroxin on thyrotropin secretion from isolated hyperthyroid_pituitaries .
3830083	0	thyrotropin	26,37	neurotensin	11,22	thyrotropin	neurotensin	MESH:D013972	299757(Tax:10116)	Chemical	Gene	secretion|compound|START_ENTITY Effect|nmod|secretion Effect|nmod|END_ENTITY	-LSB- Effect of neurotensin on thyrotropin secretion in the rat .
1171113	0	thyrotropin	52,63	somatostatin	14,26	thyrotropin	somatostatin	MESH:D013972	6750	Chemical	Gene	levels|nmod|START_ENTITY END_ENTITY|nmod|levels	Inhibition by somatostatin of basal levels of serum thyrotropin -LRB- TSH -RRB- in normal men .
2811602	0	thyrotropin	45,56	thyroid_peroxidase	14,32	thyrotropin	thyroid peroxidase	MESH:D013972	7173	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Regulation of thyroid_peroxidase activity by thyrotropin , epidermal_growth_factor and phorbol_ester in porcine thyroid follicles cultured in suspension .
109290	0	thyrotropin	23,34	thyrotropin-releasing_hormone	47,76	thyrotropin	thyrotropin-releasing hormone	MESH:D013972	7200	Chemical	Gene	response|compound|START_ENTITY Comparison|nmod|response Comparison|acl|END_ENTITY	Comparison between the thyrotropin response to thyrotropin-releasing_hormone in summer and that in winter in normal subjects .
1306848	0	thyrotropin	69,80	thyrotropin-releasing_hormone	20,49	thyrotropin	thyrotropin-releasing hormone	MESH:D013972	7200	Chemical	Gene	treatment|nmod|START_ENTITY treatment|amod|END_ENTITY	Effects of tartrate thyrotropin-releasing_hormone treatment on serum thyrotropin , free triiodothyronine , free thyroxine and prolactin levels in patients with spinocerebellar_degeneration .
1443425	0	thyrotropin	67,78	thyrotropin-releasing_hormone	97,126	thyrotropin	thyrotropin-releasing hormone	MESH:D013972	7200	Chemical	Gene	triiodothyronine|nmod|START_ENTITY response|amod|triiodothyronine response|nmod|END_ENTITY	Evidence for normal feedback inhibition of triiodothyronine on the thyrotropin -LRB- TSH -RRB- response to thyrotropin-releasing_hormone -LRB- TRH -RRB- in abstinent male alcoholics .
1710331	0	thyrotropin	63,74	thyrotropin-releasing_hormone	13,42	thyrotropin	thyrotropin-releasing hormone	MESH:D013972	25569(Tax:10116)	Chemical	Gene	beta|compound|START_ENTITY regulates|dobj|beta regulates|nsubj|END_ENTITY	Hypothalamic thyrotropin-releasing_hormone regulates pituitary thyrotropin beta - and alpha-subunit mRNA levels in the rat .
2497398	0	thyrotropin	35,46	thyrotropin-releasing_hormone	60,89	thyrotropin	thyrotropin-releasing hormone	MESH:D013972	25569(Tax:10116)	Chemical	Gene	control|nmod|START_ENTITY age|nmod|control Influence|nmod|age secretion|nsubj|Influence secretion|nmod|END_ENTITY	Influence of age on the control of thyrotropin secretion by thyrotropin-releasing_hormone in the male rat .
2514396	0	thyrotropin	53,64	thyrotropin-releasing_hormone	100,129	thyrotropin	thyrotropin-releasing hormone	MESH:D013972	25569(Tax:10116)	Chemical	Gene	START_ENTITY|acl|induced induced|nmod|potassium potassium|amod|END_ENTITY	Lidocaine inhibits dispersed anterior pituitary cell thyrotropin and prolactin secretion induced by thyrotropin-releasing_hormone or high medium potassium .
2514397	0	thyrotropin	146,157	thyrotropin-releasing_hormone	34,63	thyrotropin	thyrotropin-releasing hormone	MESH:D013972	25569(Tax:10116)	Chemical	Gene	regulation|compound|START_ENTITY involved|nmod|regulation nucleus|acl:relcl|involved lowers|nmod|nucleus lowers|dobj|concentrations concentrations|amod|END_ENTITY	Exogenous triiodothyronine lowers thyrotropin-releasing_hormone concentrations in the specific hypothalamic nucleus -LRB- paraventricular -RRB- involved in thyrotropin regulation and also in posterior nucleus .
2875702	0	thyrotropin	12,23	thyrotropin-releasing_hormone	27,56	thyrotropin	thyrotropin-releasing hormone	MESH:D013972	7200	Chemical	Gene	Response|nmod|START_ENTITY Response|acl|END_ENTITY	Response of thyrotropin to thyrotropin-releasing_hormone as predictor of treatment outcome .
2966827	0	thyrotropin	63,74	thyrotropin-releasing_hormone	84,113	thyrotropin	thyrotropin-releasing hormone	MESH:D013972	7200	Chemical	Gene	stimulation|nmod|START_ENTITY loss|nmod|stimulation effects|nmod|loss effects|nmod|END_ENTITY	The effects of dieting and weight loss upon the stimulation of thyrotropin -LRB- TSH -RRB- by thyrotropin-releasing_hormone -LRB- TRH -RRB- and suppression of cortisol secretion by dexamethasone in men and women .
3011129	0	thyrotropin	70,81	thyrotropin-releasing_hormone	102,131	thyrotropin	thyrotropin-releasing hormone	MESH:D013972	7200	Chemical	Gene	secretion|compound|START_ENTITY secretion|nmod|END_ENTITY	Human corticotropin-releasing_hormone in depression -- correlation with thyrotropin secretion following thyrotropin-releasing_hormone .
3081419	0	thyrotropin	62,73	thyrotropin-releasing_hormone	92,121	thyrotropin	thyrotropin-releasing hormone	MESH:D013972	7200	Chemical	Gene	response|amod|START_ENTITY response|nmod|END_ENTITY	Cardiopulmonary bypass : a low T4 and T3 syndrome with blunted thyrotropin -LRB- TSH -RRB- response to thyrotropin-releasing_hormone -LRB- TRH -RRB- .
3091628	0	thyrotropin	25,36	thyrotropin-releasing_hormone	99,128	thyrotropin	thyrotropin-releasing hormone	MESH:D013972	7200	Chemical	Gene	thyroxine|nmod|START_ENTITY treatment|amod|thyroxine treatment|amod|END_ENTITY	Sustained rises in serum thyrotropin , thyroxine , and triiodothyronine during long term , continuous thyrotropin-releasing_hormone treatment in patients with amyotrophic_lateral_sclerosis .
3104329	0	thyrotropin	88,99	thyrotropin-releasing_hormone	10,39	thyrotropin	thyrotropin-releasing hormone	MESH:D013972	22044(Tax:10090)	Chemical	Gene	structure|nmod|START_ENTITY Effect|nmod|structure Effect|nmod|END_ENTITY	Effect of thyrotropin-releasing_hormone on the carbohydrate structure of secreted mouse thyrotropin .
3108919	0	thyrotropin	6,17	thyrotropin-releasing_hormone	37,66	thyrotropin	thyrotropin-releasing hormone	MESH:D013972	7200	Chemical	Gene	responses|compound|START_ENTITY responses|dep|END_ENTITY	Serum thyrotropin -LRB- TSH -RRB- responses to thyrotropin-releasing_hormone -LRB- TRH -RRB- in patients with anorexia_nervosa and bulimia : influence of changes in body weight and eating_disorders .
3114044	0	thyrotropin	53,64	thyrotropin-releasing_hormone	11,40	thyrotropin	thyrotropin-releasing hormone	MESH:D013972	7200	Chemical	Gene	vitro|nmod|START_ENTITY END_ENTITY|acl|vitro	Effects of thyrotropin-releasing_hormone in vitro on thyrotropin and prolactin release from the turtle pituitary .
3116574	0	thyrotropin	45,56	thyrotropin-releasing_hormone	69,98	thyrotropin	thyrotropin-releasing hormone	MESH:D013972	7200	Chemical	Gene	response|amod|START_ENTITY response|acl|END_ENTITY	Pirenzepine inhibits growth_hormone , but not thyrotropin response to thyrotropin-releasing_hormone in patients with endogenous_depression .
413330	0	thyrotropin	84,95	thyrotropin-releasing_hormone	36,65	thyrotropin	thyrotropin-releasing hormone	MESH:D013972	7200	Chemical	Gene	release|nmod|START_ENTITY action|nmod|release action|nmod|analogs analogs|nmod|END_ENTITY	The inhibitory action of analogs of thyrotropin-releasing_hormone on the release of thyrotropin in vitro .
4621544	0	thyrotropin	6,17	thyrotropin-releasing_hormone	41,70	thyrotropin	thyrotropin-releasing hormone	MESH:D013972	7200	Chemical	Gene	responses|compound|START_ENTITY Serum|dobj|responses Serum|nmod|END_ENTITY	Serum thyrotropin responses to synthetic thyrotropin-releasing_hormone in normal children and hypopituitary patients .
6428472	0	thyrotropin	92,103	thyrotropin-releasing_hormone	18,47	thyrotropin	thyrotropin-releasing hormone	MESH:D013972	7200	Chemical	Gene	response|compound|START_ENTITY Administration|nmod|response Administration|nmod|results results|amod|END_ENTITY	Administration of thyrotropin-releasing_hormone at weekly intervals results in a diminished thyrotropin response .
6439618	0	thyrotropin	73,84	thyrotropin-releasing_hormone	34,63	thyrotropin	thyrotropin-releasing hormone	MESH:D013972	25569(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of repeated stimulation by thyrotropin-releasing_hormone -LRB- TRH -RRB- on thyrotropin and prolactin secretion in perfused euthyroid and hypothyroid rat pituitary fragments .
6793611	0	thyrotropin	35,46	thyrotropin-releasing_hormone	115,144	thyrotropin	thyrotropin-releasing hormone	MESH:D013972	7200	Chemical	Gene	concentrations|nmod|START_ENTITY concentrations|nmod|END_ENTITY	Human cord blood concentrations of thyrotropin , thyroglobulin , and iodothyronines after maternal administration of thyrotropin-releasing_hormone .
72658	0	thyrotropin	6,17	thyrotropin-releasing_hormone	30,59	thyrotropin	thyrotropin-releasing hormone	MESH:D013972	7200	Chemical	Gene	response|compound|START_ENTITY response|nmod|hormone hormone|amod|END_ENTITY	Serum thyrotropin response to thyrotropin-releasing_hormone and free thyroid hormone indices in patients with familial_thyroxine-binding_globulin_deficiency .
803974	0	thyrotropin	16,27	thyrotropin-releasing_hormone	41,70	thyrotropin	thyrotropin-releasing hormone	MESH:D013972	7200	Chemical	Gene	responses|compound|START_ENTITY Augmentation|nmod|responses Augmentation|nmod|decreases decreases|amod|END_ENTITY	Augmentation of thyrotropin responses to thyrotropin-releasing_hormone following small decreases in serum thyroid hormone concentrations .
80734	0	thyrotropin	21,32	thyrotropin-releasing_hormone	138,167	thyrotropin	thyrotropin-releasing hormone	MESH:D013972	25569(Tax:10116)	Chemical	Gene	Suppression|nmod|START_ENTITY concentrations|nsubj|Suppression concentrations|nmod|END_ENTITY	Suppression of serum thyrotropin -LRB- TSH -RRB- concentrations following thyroidectomy and cold exposure by passive immunization with antiserum to thyrotropin-releasing_hormone -LRB- TRH -RRB- in rats .
813994	0	thyrotropin	94,105	thyrotropin-releasing_hormone	43,72	thyrotropin	thyrotropin-releasing hormone	MESH:D013972	25569(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY Characteristics|nmod|release Characteristics|nmod|interaction interaction|nmod|END_ENTITY	Characteristics of the interaction between thyrotropin-releasing_hormone and somatostatin for thyrotropin and prolactin release .
825527	0	thyrotropin	56,67	thyrotropin-releasing_hormone	10,39	thyrotropin	thyrotropin-releasing hormone	MESH:D013972	702455(Tax:9544)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of thyrotropin-releasing_hormone on secretion of thyrotropin , prolactin , thyroxine , and triiodothyronine in pregnant and fetal rhesus_monkeys .
827433	0	thyrotropin	16,27	thyrotropin-releasing_hormone	41,70	thyrotropin	thyrotropin-releasing hormone	MESH:D013972	7200	Chemical	Gene	responses|compound|START_ENTITY Augmentation|nmod|responses Augmentation|nmod|iodide iodide|amod|END_ENTITY	Augmentation of thyrotropin responses to thyrotropin-releasing_hormone following inorganic iodide .
828576	0	thyrotropin	6,17	thyrotropin-releasing_hormone	30,59	thyrotropin	thyrotropin-releasing hormone	MESH:D013972	7200	Chemical	Gene	response|compound|START_ENTITY response|nmod|hormone hormone|amod|END_ENTITY	Serum thyrotropin response to thyrotropin-releasing_hormone and free thyroid hormone indices in patients with familiar_thyroxine-binding_globulin_deficiency .
8618941	0	thyrotropin	37,48	thyrotropin-releasing_hormone	72,101	thyrotropin	thyrotropin-releasing hormone	MESH:D013972	25569(Tax:10116)	Chemical	Gene	neuromedin_B|nmod|START_ENTITY Role|nmod|neuromedin_B release|nsubj|Role release|xcomp|END_ENTITY	Role of neuromedin_B in the in vitro thyrotropin release in response to thyrotropin-releasing_hormone from anterior pituitaries of eu - , hypo - , and hyperthyroid rats .
8906724	0	thyrotropin	53,64	thyrotropin-releasing_hormone	14,43	thyrotropin	thyrotropin-releasing hormone	MESH:D013972	484643(Tax:9615)	Chemical	Gene	stimulation|amod|START_ENTITY Comparison|nmod|stimulation Comparison|nmod|END_ENTITY	Comparison of thyrotropin-releasing_hormone -LRB- TRH -RRB- to thyrotropin -LRB- TSH -RRB- stimulation for evaluating thyroid function in dogs .
9209609	0	thyrotropin	44,55	thyrotropin-releasing_hormone	87,116	thyrotropin	thyrotropin-releasing hormone	MESH:D013972	7200	Chemical	Gene	secretion|compound|START_ENTITY correlates|nmod|secretion correlates|nmod|END_ENTITY	Plasma somatostatin correlates with blunted thyrotropin secretion after stimulation by thyrotropin-releasing_hormone in critical_illness .
9827654	0	thyrotropin	48,59	thyrotropin-releasing_hormone	73,102	thyrotropin	thyrotropin-releasing hormone	MESH:D013972	7200	Chemical	Gene	gland|nmod|START_ENTITY response|nmod|gland increased|nsubj|response increased|nmod|END_ENTITY	Low response of the thyroid gland to endogenous thyrotropin increased by thyrotropin-releasing_hormone in patients with euthyroid Graves ' disease .
409475	0	thyrotropin	26,37	thyrotropin_releasing_hormone	90,119	thyrotropin	thyrotropin releasing hormone	MESH:D013972	7200	Chemical	Gene	responses|compound|START_ENTITY somatostatin|nmod|responses Effect|nmod|somatostatin Effect|acl|END_ENTITY	Effect of somatostatin on thyrotropin , prolactin , growth_hormone and insulin responses to thyrotropin_releasing_hormone and arginine in healthy , hypothyroid and acromegalic subjects .
418585	0	thyrotropin	65,76	thyrotropin_releasing_hormone	15,44	thyrotropin	thyrotropin releasing hormone	MESH:D013972	7200	Chemical	Gene	levels|compound|START_ENTITY Effect|nmod|levels Effect|nmod|END_ENTITY	Effect of oral thyrotropin_releasing_hormone on serum prolactin , thyrotropin and total thyroxine levels in postpartum women .
811471	0	thyrotropin	16,27	thyrotropin_releasing_hormone	69,98	thyrotropin	thyrotropin releasing hormone	MESH:D013972	7200	Chemical	Gene	response|nmod|START_ENTITY response|nmod|END_ENTITY	The response of thyrotropin and triiodothyronine to various doses of thyrotropin_releasing_hormone in normal man .
15640901	0	thyroxin	133,141	thyroglobulin	113,126	thyroxin	thyroglobulin	MESH:D013974	7038	Chemical	Gene	withdrawal|compound|START_ENTITY END_ENTITY|nmod|withdrawal	-LSB- Usefulness of radioiodine scanning in patients with moderate/high risk differentiated thyroid_carcinoma in whom thyroglobulin after thyroxin withdrawal is undetectable after initial treatment -RSB- .
627067	0	thyroxine	31,40	ARIA	51,55	thyroxine	ARIA	MESH:D013974	641700	Chemical	Gene	START_ENTITY|nmod|II II|compound|END_ENTITY	Automated measurement of serum thyroxine with the `` ARIA II , '' as compared with competitive protein binding and radioimmunoassay .
1690421	0	thyroxine	10,19	CCK	58,61	thyroxine	CCK	MESH:D013974	25298(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Effect of thyroxine on the maturation of cholecystokinin -LRB- CCK -RRB- receptors in pancreatic acini of neonatal rats .
6334836	0	thyroxine	70,79	Epidermal_growth_factor	0,23	thyroxine	Epidermal growth factor	MESH:D013974	13645(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|dep|effect	Epidermal_growth_factor in neonatal mouse urine : maturative effect of thyroxine .
11980630	0	thyroxine	18,27	IGF-I	41,46	thyroxine	IGF-I	MESH:D013974	24482(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY treatment|nmod|END_ENTITY	Effect of chronic thyroxine treatment on IGF-I , IGF-II and IGF-binding protein expression in mammary gland and liver during pregnancy and early lactation in rats .
17121519	0	thyroxine	10,19	IGF-I	41,46	thyroxine	IGF-I	MESH:D013974	3479	Chemical	Gene	replacement|amod|START_ENTITY Effect|nmod|replacement Effect|nmod|END_ENTITY	Effect of thyroxine replacement on serum IGF-I , IGFBP-3 and the acid-labile_subunit in patients with hypothyroidism and hypopituitarism .
8816035	0	thyroxine	120,129	IGF-I	107,112	thyroxine	IGF-I	MESH:D013974	3479	Chemical	Gene	free|dobj|START_ENTITY free|nsubj|parameters parameters|appos|response response|dep|insulin-like_growth_factor-I insulin-like_growth_factor-I|appos|END_ENTITY	Growth parameters , growth_hormone -LRB- GH -RRB- response to clonidine and circulating insulin-like_growth_factor-I -LRB- IGF-I -RRB- , free thyroxine -LRB- FT4 -RRB- and cortisol concentrations in relation to glycaemic control in children with insulin-dependent_diabetes_mellitus .
6307846	0	thyroxine	60,69	T3	97,99	thyroxine	T3	MESH:D013974	100327341(Tax:9031)	Chemical	Gene	_|amod|START_ENTITY _|appos|END_ENTITY	Effects of glucocorticoids on circulating concentrations of thyroxine _ -LRB- T4 -RRB- and triiodothyronine -LRB- T3 -RRB- and on peripheral monodeiodination in pre - and post-hatching chickens .
6307846	0	thyroxine	60,69	T4	71,73	thyroxine	T4	MESH:D013974	100327330(Tax:9031)	Chemical	Gene	_|amod|START_ENTITY _|appos|END_ENTITY	Effects of glucocorticoids on circulating concentrations of thyroxine _ -LRB- T4 -RRB- and triiodothyronine -LRB- T3 -RRB- and on peripheral monodeiodination in pre - and post-hatching chickens .
11849618	0	thyroxine	30,39	TBG	44,47	thyroxine	TBG	MESH:D013974	6906	Chemical	Gene	START_ENTITY|nmod|binding binding|compound|END_ENTITY	Competition of tamoxifen with thyroxine for TBG binding : ligand binding assay and computational data .
22820390	0	thyroxine	6,15	TBG	34,37	thyroxine	TBG	MESH:D013974	6906	Chemical	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Human thyroxine binding globulin -LRB- TBG -RRB- promoter directs efficient and sustaining transgene expression in liver-specific pattern .
404816	0	thyroxine	27,36	TBG	69,72	thyroxine	TBG	MESH:D013974	6906	Chemical	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	Changes in serum levels of thyroxine and thyroxine-binding proteins -LRB- TBG , TBPA , ALBUMIN -RRB- induced by venous_stasis .
111446	0	thyroxine	42,51	TRH	35,38	thyroxine	TRH	MESH:D013974	7200	Chemical	Gene	therapy|amod|START_ENTITY END_ENTITY|nmod|therapy	Suppression of the TSH response to TRH by thyroxine therapy in differentiated thyroid_carcinoma patients .
26831555	5	thyroxine	840,849	TRH	899,902	thyroxine	TRH	MESH:D013974	7200	Chemical	Gene	level|compound|START_ENTITY ng/mL|nsubj|level ng/mL|nmod|time time|nmod|test test|compound|END_ENTITY	The median basal TSH was 7.0 mIU/L -LRB- 4.9-8 .9 -RRB- and free thyroxine level was 1.4 ng/mL -LRB- 1.2-1 .6 -RRB- at the time of the TRH test .
414907	0	thyroxine	11,20	TRH	55,58	thyroxine	TRH	MESH:D013974	25569(Tax:10116)	Chemical	Gene	exposure|amod|START_ENTITY Effects|nmod|exposure Effects|nmod|levels levels|compound|END_ENTITY	Effects of thyroxine and cold exposure on hypothalamic TRH levels in rats with various pituitary-thyroid states .
6781851	0	thyroxine	60,69	TRH	20,23	thyroxine	TRH	MESH:D013974	7200	Chemical	Gene	treatment|amod|START_ENTITY determination|nmod|treatment Standardisation|nmod|determination Standardisation|nmod|test test|compound|END_ENTITY	-LSB- Standardisation of TRH test for the exact determination of thyroxine treatment -LRB- author 's transl -RRB- -RSB- .
805438	0	thyroxine	63,72	TRH	41,44	thyroxine	TRH	MESH:D013974	613414(Tax:9913)	Chemical	Gene	levels|compound|START_ENTITY Effect|nmod|levels Effect|appos|END_ENTITY	Effect of thyrotropin-releasing_hormone -LRB- TRH -RRB- on bovine plasma thyroxine levels at 18.5 and 35 C. Six mature nonlactating Holstein cows were subjected to a test procedure of a sham period -LRB- saline injection -RRB- of 10 days that prededed and followed each 14 day TRH treatment period at 18.5 and 35 degrees .
8149219	0	thyroxine	90,99	Transthyretin	0,13	thyroxine	Transthyretin	MESH:D013974	24856(Tax:10116)	Chemical	Gene	transport|amod|START_ENTITY effect|nmod|transport expression|dep|effect expression|compound|END_ENTITY	Transthyretin expression in the rat brain : effect of thyroid functional state and role in thyroxine transport .
9124556	0	thyroxine	35,44	Transthyretin	0,13	thyroxine	Transthyretin	MESH:D013974	22139(Tax:10090)	Chemical	Gene	essential|nmod|START_ENTITY essential|nsubj|END_ENTITY	Transthyretin is not essential for thyroxine to reach the brain and other tissues in transthyretin-null mice .
1567478	0	thyroxine	61,70	UDP-glucuronosyltransferase	17,44	thyroxine	UDP-glucuronosyltransferase	MESH:D013974	24862(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Male rat hepatic UDP-glucuronosyltransferase activity toward thyroxine .
16049124	0	thyroxine	18,27	UDP-glucuronosyltransferase	111,138	thyroxine	UDP-glucuronosyltransferase	MESH:D013974	24862(Tax:10116)	Chemical	Gene	level|compound|START_ENTITY Decrease|nmod|level dependent|nsubj|Decrease dependent|nmod|increase increase|nmod|END_ENTITY	Decrease in serum thyroxine level by phenobarbital in rats is not necessarily dependent on increase in hepatic UDP-glucuronosyltransferase .
8477975	0	thyroxine	11,20	alcohol_dehydrogenase	42,63	thyroxine	alcohol dehydrogenase	MESH:D013974	78959(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of thyroxine on the expression of alcohol_dehydrogenase in rat liver and kidney .
6414878	2	thyroxine	144,153	alpha-MSH	169,178	thyroxine	alpha-MSH	MESH:D013974	5443	Chemical	Gene	Lack|nmod|START_ENTITY Lack|nmod|secretion secretion|amod|END_ENTITY	Lack of action of thyroxine on TRH-induced alpha-MSH secretion .
9492057	0	thyroxine	15,24	cholecystokinin	84,99	thyroxine	cholecystokinin	MESH:D013974	25298(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Interaction of thyroxine and estrogen on the expression of estrogen receptor alpha , cholecystokinin , and preproenkephalin messenger ribonucleic_acid in the limbic-hypothalamic circuit .
2226315	0	thyroxine	10,19	epidermal_growth_factor	56,79	thyroxine	epidermal growth factor	MESH:D013974	13645(Tax:10090)	Chemical	Gene	administration|amod|START_ENTITY Effect|nmod|administration Effect|nmod|expression expression|nmod|END_ENTITY	Effect of thyroxine administration on the expression of epidermal_growth_factor in the kidney and submandibular gland of neonatal mice .
3876870	0	thyroxine	88,97	epidermal_growth_factor	52,75	thyroxine	epidermal growth factor	MESH:D013974	13645(Tax:10090)	Chemical	Gene	alters|advcl|START_ENTITY alters|dobj|response response|compound|END_ENTITY	Neonatal_hyperthyroidism alters submandibular gland epidermal_growth_factor response to thyroxine in the adult mouse .
1011167	0	thyroxine	9,18	growth_hormone	41,55	thyroxine	growth hormone	MESH:D013974	81668(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|effects effects|nmod|END_ENTITY	-LSB- Need of thyroxine in chronic effects of growth_hormone -LRB- GH -RRB- on phosphorus and calcium metabolism of female adult rat -LRB- author 's transl -RRB- -RSB- .
1761276	0	thyroxine	82,91	growth_hormone	40,54	thyroxine	growth hormone	MESH:D013974	378781(Tax:9031)	Chemical	Gene	stimulation|nmod|START_ENTITY stimulation|amod|END_ENTITY	Food intake after hatching inhibits the growth_hormone induced stimulation of the thyroxine to triiodothyronine conversion in the chicken .
9748401	0	thyroxine	86,95	insulin-like_growth_factor-1	18,46	thyroxine	insulin-like growth factor-1	MESH:D013974	101055342	Chemical	Gene	effect|nmod|START_ENTITY expression|dep|effect expression|nmod|END_ENTITY	The expression of insulin-like_growth_factor-1 during adipogenesis in vivo : effect of thyroxine .
9357766	0	thyroxine	44,53	interferon-gamma	79,95	thyroxine	interferon-gamma	MESH:D013974	3458	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	Protein synthesis-dependent potentiation by thyroxine of antiviral activity of interferon-gamma .
15068404	0	thyroxine	13,22	interleukin-2_receptor_alpha	40,68	thyroxine	interleukin-2 receptor alpha	MESH:D013974	3559	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|levels levels|amod|END_ENTITY	Influence of thyroxine on serum soluble interleukin-2_receptor_alpha levels in thyroid_disorders .
3983106	0	thyroxine	11,20	methemoglobin	24,37	thyroxine	methemoglobin	MESH:D013974	3048	Chemical	Gene	START_ENTITY|nmod|content content|compound|END_ENTITY	-LSB- Effect of thyroxine on methemoglobin content and the activity of antioxidant enzymes of human erythrocytes in vitro -RSB- .
20543552	0	thyroxine	10,19	synaptotagmin_1	23,38	thyroxine	synaptotagmin 1	MESH:D013974	25716(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of thyroxine on synaptotagmin_1 and SNAP-25 expression in dorsal hippocampus of adult-onset hypothyroid rats .
115316	0	thyroxine	66,75	thyrotropin-releasing_hormone	143,172	thyroxine	thyrotropin-releasing hormone	MESH:D013974	7200	Chemical	Gene	concentrations|amod|START_ENTITY concentrations|nmod|administration administration|nmod|END_ENTITY	Plasma thyrotropin-releasing_hormone , prolactin , thyrotropin , and thyroxine concentrations following the intravenous or oral administration of thyrotropin-releasing_hormone .
1306848	0	thyroxine	110,119	thyrotropin-releasing_hormone	20,49	thyroxine	thyrotropin-releasing hormone	MESH:D013974	7200	Chemical	Gene	Effects|appos|START_ENTITY Effects|nmod|treatment treatment|amod|END_ENTITY	Effects of tartrate thyrotropin-releasing_hormone treatment on serum thyrotropin , free triiodothyronine , free thyroxine and prolactin levels in patients with spinocerebellar_degeneration .
2122431	0	thyroxine	114,123	thyrotropin-releasing_hormone	10,39	thyroxine	thyrotropin-releasing hormone	MESH:D013974	414344(Tax:9031)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|triiodothyronine triiodothyronine|compound|END_ENTITY	Effect of thyrotropin-releasing_hormone , triiodothyronine , and chicken growth_hormone on plasma concentrations of thyroxine , triiodothyronine , growth_hormone , and growth of lymphoid organs and leukocyte populations in immature male chickens .
3080928	0	thyroxine	68,77	thyrotropin-releasing_hormone	11,40	thyroxine	thyrotropin-releasing hormone	MESH:D013974	484643(Tax:9615)	Chemical	Gene	concentrations|nmod|START_ENTITY END_ENTITY|nmod|concentrations	Effects of thyrotropin-releasing_hormone on serum concentrations of thyroxine and triiodothyronine in healthy , thyroidectomized , thyroxine-treated , and propylthiouracil-treated dogs .
3091628	0	thyroxine	38,47	thyrotropin-releasing_hormone	99,128	thyroxine	thyrotropin-releasing hormone	MESH:D013974	7200	Chemical	Gene	treatment|amod|START_ENTITY treatment|amod|END_ENTITY	Sustained rises in serum thyrotropin , thyroxine , and triiodothyronine during long term , continuous thyrotropin-releasing_hormone treatment in patients with amyotrophic_lateral_sclerosis .
3132791	0	thyroxine	103,112	thyrotropin-releasing_hormone	40,69	thyroxine	thyrotropin-releasing hormone	MESH:D013974	7200	Chemical	Gene	reproduced|nmod|START_ENTITY reproduced|nsubj|response response|nmod|END_ENTITY	Suppressed plasma prolactin response to thyrotropin-releasing_hormone in hyperthyroidism reproduced by thyroxine but not by triiodothyronine administration to normal subjects .
3922262	0	thyroxine	24,33	thyrotropin-releasing_hormone	112,141	thyroxine	thyrotropin-releasing hormone	MESH:D013974	484643(Tax:9615)	Chemical	Gene	concentrations|nmod|START_ENTITY concentrations|dep|triiodothyronine triiodothyronine|nmod|dogs dogs|nmod|administration administration|amod|END_ENTITY	Serum concentrations of thyroxine , 3,5,3 ' - triiodothyronine , thyrotropin , and prolactin in dogs before and after thyrotropin-releasing_hormone administration .
6401761	0	thyroxine	38,47	thyrotropin-releasing_hormone	114,143	thyroxine	thyrotropin-releasing hormone	MESH:D013974	702455(Tax:9544)	Chemical	Gene	responses|amod|START_ENTITY responses|nmod|END_ENTITY	Different prolactin , thyrotropin , and thyroxine responses after prolonged intermittent or continuous infusions of thyrotropin-releasing_hormone in rhesus_monkeys .
6804476	0	thyroxine	186,195	thyrotropin-releasing_hormone	82,111	thyroxine	thyrotropin-releasing hormone	MESH:D013974	7200	Chemical	Gene	dosage|nmod|START_ENTITY END_ENTITY|nmod|dosage	Seasonal variation of serum thyrotropin concentration and thyrotropin response to thyrotropin-releasing_hormone in patients with primary_hypothyroidism on constant replacement dosage of thyroxine .
803298	0	thyroxine	107,116	thyrotropin-releasing_hormone	50,79	thyroxine	thyrotropin-releasing hormone	MESH:D013974	7200	Chemical	Gene	concentrations|compound|START_ENTITY analyses|nmod|concentrations based|nmod|analyses based|nsubj|responsiveness responsiveness|nmod|END_ENTITY	Pituitary-thyroid responsiveness to intramuscular thyrotropin-releasing_hormone based on analyses of serum thyroxine , tri-iodothyronine and thyrotropin concentrations .
805438	0	thyroxine	63,72	thyrotropin-releasing_hormone	10,39	thyroxine	thyrotropin-releasing hormone	MESH:D013974	613414(Tax:9913)	Chemical	Gene	levels|compound|START_ENTITY Effect|nmod|levels Effect|nmod|END_ENTITY	Effect of thyrotropin-releasing_hormone -LRB- TRH -RRB- on bovine plasma thyroxine levels at 18.5 and 35 C. Six mature nonlactating Holstein cows were subjected to a test procedure of a sham period -LRB- saline injection -RRB- of 10 days that prededed and followed each 14 day TRH treatment period at 18.5 and 35 degrees .
8159269	0	thyroxine	26,35	thyrotropin-releasing_hormone	70,99	thyroxine	thyrotropin-releasing hormone	MESH:D013974	25569(Tax:10116)	Chemical	Gene	Interrelationship|nmod|START_ENTITY Interrelationship|nmod|secretion secretion|nmod|END_ENTITY	Interrelationship between thyroxine and estradiol on the secretion of thyrotropin-releasing_hormone and dopamine into hypophysial portal blood in ovariectomized-thyroidectomized rats .
8481955	0	thyroxine	124,133	thyrotropin-releasing_hormone	151,180	thyroxine	thyrotropin-releasing hormone	MESH:D013974	25569(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY treatment|acl|and/or and/or|dobj|treatment treatment|amod|END_ENTITY	Morphofunctional study on prolactin-producing cells of the anterior pituitaries in adult male rats following thyroidectomy , thyroxine treatment and/or thyrotropin-releasing_hormone treatment .
418585	0	thyroxine	87,96	thyrotropin_releasing_hormone	15,44	thyroxine	thyrotropin releasing hormone	MESH:D013974	7200	Chemical	Gene	levels|compound|START_ENTITY Effect|nmod|levels Effect|nmod|END_ENTITY	Effect of oral thyrotropin_releasing_hormone on serum prolactin , thyrotropin and total thyroxine levels in postpartum women .
10319941	0	thyroxine	62,71	thyroxine-binding_globulin	77,103	thyroxine	thyroxine-binding globulin	MESH:D013974	6906	Chemical	Gene	displacement|nmod|START_ENTITY and|dobj|displacement and|nmod|END_ENTITY	Salsalate and salicylate binding to and their displacement of thyroxine from thyroxine-binding_globulin , transthyrin , and albumin .
1623594	0	thyroxine	19,28	thyroxine-binding_globulin	105,131	thyroxine	thyroxine-binding globulin	MESH:D013974	6906	Chemical	Gene	estimates|compound|START_ENTITY Dependence|nmod|estimates obtained|nsubj|Dependence obtained|nmod|concentration concentration|nmod|END_ENTITY	Dependence of free thyroxine estimates obtained with equilibrium tracer dialysis on the concentration of thyroxine-binding_globulin .
6184213	0	thyroxine	10,19	thyroxine-binding_globulin	69,95	thyroxine	thyroxine-binding globulin	MESH:D013974	6906	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of thyroxine on molecular properties of native and dansylated thyroxine-binding_globulin .
7488876	0	thyroxine	60,69	thyroxine-binding_globulin	81,107	thyroxine	thyroxine-binding globulin	MESH:D013974	6906	Chemical	Gene	fatty_acids|nmod|START_ENTITY Influence|nmod|fatty_acids Influence|amod|binding binding|nmod|END_ENTITY	Influence of nonesterified fatty_acids and lysolecithins on thyroxine binding to thyroxine-binding_globulin and transthyretin .
4968803	0	thyroxine	67,76	thyroxine-binding_prealbumin	20,48	thyroxine	thyroxine-binding prealbumin	MESH:D013974	7276	Chemical	Gene	contribution|nmod|START_ENTITY contribution|nmod|END_ENTITY	The contribution of thyroxine-binding_prealbumin to the binding of thyroxine in human serum , as assessed by immunoadsorption .
10036215	0	thyroxine	103,112	transthyretin	50,63	thyroxine	transthyretin	MESH:D013974	24856(Tax:10116)	Chemical	Gene	relation|acl|START_ENTITY Inhibition|dep|relation Inhibition|nmod|END_ENTITY	Inhibition by lead of production and secretion of transthyretin in the choroid plexus : its relation to thyroxine transport at blood-CSF barrier .
10631123	0	thyroxine	97,106	transthyretin	80,93	thyroxine	transthyretin	MESH:D013974	7276	Chemical	Gene	protein|amod|START_ENTITY END_ENTITY|appos|protein	Assessing the role of ortho-substitution on polychlorinated_biphenyl binding to transthyretin , a thyroxine transport protein .
11352912	5	thyroxine	1014,1023	transthyretin	983,996	thyroxine	transthyretin	MESH:D013974	7276	Chemical	Gene	native|amod|START_ENTITY native|nmod:poss|END_ENTITY	The synthetic protein was folded and assembled to a tetrameric structure in the presence of transthyretin 's native ligand , thyroxine , as shown by gel filtration chromatography , native gel electrophoresis , transthyretin antibody recognition , and thyroid hormone binding .
1356051	0	thyroxine	88,97	transthyretin	19,32	thyroxine	transthyretin	MESH:D013974	7276	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubj|variant variant|nmod|END_ENTITY	A novel variant of transthyretin -LRB- prealbumin -RRB- , Thr119_to_Met , associated with increased thyroxine binding .
15299640	0	thyroxine	49,58	transthyretin	20,33	thyroxine	transthyretin	MESH:D013974	7276	Chemical	Gene	complexed|nmod|START_ENTITY END_ENTITY|acl|complexed	Structures of human transthyretin complexed with thyroxine at 2.0 A resolution and 3 ' ,5 ' - dinitro-N-acetyl-L-thyronine at 2.2 A resolution .
1733735	0	thyroxine	42,51	transthyretin	8,21	thyroxine	transthyretin	MESH:D013974	24856(Tax:10116)	Chemical	Gene	transport|nmod|START_ENTITY Role|nmod|transport Role|nmod|END_ENTITY	Role of transthyretin in the transport of thyroxine from the blood to the choroid plexus , the cerebrospinal fluid , and the brain .
1979335	0	thyroxine	57,66	transthyretin	20,33	thyroxine	transthyretin	MESH:D013974	7276	Chemical	Gene	increases|nmod|START_ENTITY increases|nsubj|mutation mutation|nmod|END_ENTITY	A point mutation in transthyretin increases affinity for thyroxine and produces euthyroid_hyperthyroxinemia .
21146209	0	thyroxine	73,82	transthyretin	56,69	thyroxine	transthyretin	MESH:D013974	7276	Chemical	Gene	protein|amod|START_ENTITY END_ENTITY|appos|protein	Oxygen concentration regulates expression and uptake of transthyretin , a thyroxine binding protein , in JEG-3 choriocarcinoma cells .
2351100	0	thyroxine	47,56	transthyretin	73,86	thyroxine	transthyretin	MESH:D013974	24856(Tax:10116)	Chemical	Gene	displaces|dobj|START_ENTITY displaces|nmod|END_ENTITY	Flavonoid administration immediately displaces thyroxine -LRB- T4 -RRB- from serum transthyretin , increases serum free T4 , and decreases serum thyrotropin in the rat .
2498384	0	thyroxine	21,30	transthyretin	42,55	thyroxine	transthyretin	MESH:D013974	7276	Chemical	Gene	START_ENTITY|amod|binding binding|nmod|END_ENTITY	Drug competition for thyroxine binding to transthyretin -LRB- prealbumin -RRB- : comparison with effects on thyroxine-binding globulin .
7601162	0	thyroxine	11,20	transthyretin	28,41	thyroxine	transthyretin	MESH:D013974	397419(Tax:9823)	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of thyroxine to pig transthyretin , its cDNA structure , and other properties .
8039542	0	thyroxine	25,34	transthyretin	46,59	thyroxine	transthyretin	MESH:D013974	7276	Chemical	Gene	competition|nmod|START_ENTITY binding|nsubj|competition binding|nmod|globulin globulin|compound|END_ENTITY	Different competition of thyroxine binding to transthyretin and thyroxine-binding globulin by hydroxy-PCBs , PCDDs and PCDFs .
8280758	0	thyroxine	28,37	transthyretin	55,68	thyroxine	transthyretin	MESH:D013974	7276	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|binding binding|nmod|END_ENTITY	Retinoic_acid inhibition of thyroxine binding to human transthyretin .
19346277	0	tiagabine	68,77	GABA_transporter-1	91,109	tiagabine	GABA transporter-1	MESH:C059205	232333(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|inhibitor inhibitor|amod|END_ENTITY	Long-term anxiolytic and antidepressant-like behavioural effects of tiagabine , a selective GABA_transporter-1 -LRB- GAT-1 -RRB- inhibitor , coincide with a decrease in HPA system activity in C57BL/6 mice .
26481535	0	tiagabine	51,60	GABA_transporter_1	14,32	tiagabine	GABA transporter 1	MESH:C059205	232333(Tax:10090)	Chemical	Gene	effect|amod|START_ENTITY effect|nmod|END_ENTITY	The effect of GABA_transporter_1 -LRB- GAT1 -RRB- inhibitor , tiagabine , on scopolamine-induced memory_impairments in mice .
16504218	0	tianeptine	20,30	CRF	44,47	tianeptine	CRF	MESH:C050504	81648(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|expression expression|compound|END_ENTITY	Effects of repeated tianeptine treatment on CRF mRNA expression in non-stressed and chronic mild stress-exposed rats .
21175585	0	tianeptine	25,35	GS	92,94	tianeptine	GS	MESH:C050504	2752	Chemical	Gene	effect|nmod|START_ENTITY effect|dep|role role|nmod|END_ENTITY	The protective effect of tianeptine on Gp120-induced apoptosis in astroglial cells : role of GS and NOS , and NF-kB suppression .
11939714	0	tianeptine	10,20	proenkephalin	86,99	tianeptine	proenkephalin	MESH:C050504	29237(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of tianeptine and fluoxetine on the levels of Met-enkephalin and mRNA encoding proenkephalin in the rat .
6262702	0	tiapride	11,19	beta-endorphin	49,63	tiapride	beta-endorphin	MESH:D063325	5443	Chemical	Gene	infusion|amod|START_ENTITY infusion|nmod|levels levels|nmod|END_ENTITY	Effects of tiapride infusion on plasma levels of beta-endorphin , prolactin and dopamine in patients with pain from cancer .
6269192	0	tiapride	12,20	beta-endorphin	50,64	tiapride	beta-endorphin	MESH:D063325	5443	Chemical	Gene	infusion|amod|START_ENTITY infusion|nmod|levels levels|nmod|END_ENTITY	-LSB- Effects of tiapride infusion on plasma levels of beta-endorphin , prolactin and dopamine in patients with pain from cancer -LRB- author 's transl -RRB- -RSB- .
3359942	0	tiaprofenic_acid	16,32	glucose-6-phosphate_dehydrogenase	50,83	tiaprofenic acid	glucose-6-phosphate dehydrogenase	MESH:C021270	2539	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	Tolerability of tiaprofenic_acid in patients with glucose-6-phosphate_dehydrogenase -LRB- G6PD -RRB- deficiency .
1974479	0	tiazofurin	57,67	c-myc	19,24	tiazofurin	c-myc	MESH:C033706	24577(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Down-regulation of c-myc and c-Ha-ras gene expression by tiazofurin in rat hepatoma cells .
17478063	0	tibolone	11,19	Angiopoietin-1	43,57	tibolone	Angiopoietin-1	MESH:C027385	284	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|mRNA mRNA|compound|END_ENTITY	Effects of tibolone and its metabolites on Angiopoietin-1 , Tie-2 and tumor_necrosis_factor-alpha mRNA in Ishikawa cells .
12351557	0	tibolone	11,19	C-reactive_protein	86,104	tibolone	C-reactive protein	MESH:C027385	1401	Chemical	Gene	17beta-estradiol|amod|START_ENTITY Effects|nmod|17beta-estradiol Effects|nmod|END_ENTITY	Effects of tibolone and combined 17beta-estradiol and norethisterone_acetate on serum C-reactive_protein in healthy post-menopausal women : a randomized trial .
18584186	0	tibolone	21,29	C-reactive_protein	33,51	tibolone	C-reactive protein	MESH:C027385	1401	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Short-term effect of tibolone on C-reactive_protein in hypertensive postmenopausal women .
19012050	0	tibolone	14,22	C-reactive_protein	52,70	tibolone	C-reactive protein	MESH:C027385	1401	Chemical	Gene	therapy|compound|START_ENTITY impact|nmod|therapy impact|nmod|END_ENTITY	The impact of tibolone and hormone therapy on serum C-reactive_protein , tumor_necrosis_factor-alpha and hepatocyte growth factor in postmenopausal women .
12161050	0	tibolone	14,22	IGF-1	38,43	tibolone	IGF-1	MESH:C027385	24482(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of tibolone on endometrial IGF-1 and IGFBP-1 levels in ovariectomized rats .
16857224	0	tibolone	69,77	SULT1E1	14,21	tibolone	SULT1E1	MESH:C027385	6783	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of SULT1E1 expression in Ishikawa adenocarcinoma cells by tibolone .
16503406	0	tibolone	40,48	TNFalpha	69,77	tibolone	TNFalpha	MESH:C027385	7124	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|END_ENTITY	Effects of menopause and postmenopausal tibolone treatment on plasma TNFalpha , IL-4 , IL-10 , IL-12 cytokine pattern and some bone turnover markers .
12182896	0	tibolone	48,56	choline_acetyltransferase	60,85	tibolone	choline acetyltransferase	MESH:C027385	290567(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activities activities|amod|END_ENTITY	Effects of long-term hormone replacement and of tibolone on choline_acetyltransferase and acetylcholinesterase activities in the brains of ovariectomized , cynomologus monkeys .
16707283	0	tibolone	128,136	estrogen_receptor-alpha	68,91	tibolone	estrogen receptor-alpha	MESH:C027385	2099	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of stable transfection of human fetal osteoblast cells with estrogen_receptor-alpha on regulation of gene expression by tibolone .
25961347	0	tibolone	10,18	estrone_sulfatase	108,125	tibolone	estrone sulfatase	MESH:C027385	412	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	Effect of tibolone and its principal metabolites -LRB- 3a - _ and_3b-hydroxy , 3a-sulfate , and 4-ene derivatives -RRB- on estrone_sulfatase activity in normal and cancerous human breast tissue .
11599314	0	tibolone	36,44	insulin	55,62	tibolone	insulin	MESH:C027385	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of hormone replacement with tibolone on plasma insulin and blood glucose in postmenopause -RSB- .
11311767	0	tibolone	17,25	leptin	37,43	tibolone	leptin	MESH:C027385	3952	Chemical	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	The influence of tibolone upon serum leptin levels in post-menopausal women .
16837888	0	tibolone	78,86	leptin	6,12	tibolone	leptin	MESH:C027385	3952	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|levels levels|compound|END_ENTITY	Serum leptin levels and body composition in postmenopausal women treated with tibolone and raloxifene .
16899995	0	tibolone	11,19	sulfatase	23,32	tibolone	sulfatase	MESH:C027385	347527	Chemical	Gene	START_ENTITY|nmod|pathway pathway|amod|END_ENTITY	Effects of tibolone on sulfatase pathway of estrogens metabolism and on growth of MCF-7 human breast_tumors implanted in ovariectomized nude_mice .
15296473	0	tibolone	27,35	vascular_endothelial_growth_factor	66,100	tibolone	vascular endothelial growth factor	MESH:C027385	7422	Chemical	Gene	START_ENTITY|advcl|circulating circulating|dobj|END_ENTITY	Effect of hormone_therapy , tibolone and raloxifene on circulating vascular_endothelial_growth_factor in Greek postmenopausal women .
19692114	0	ticagrelor	14,24	P2Y	44,47	ticagrelor	P2Y	MESH:C503700	25265(Tax:10116)	Chemical	Gene	Comparison|nmod|START_ENTITY END_ENTITY|nsubj|Comparison	Comparison of ticagrelor and thienopyridine P2Y -LRB- 12 -RRB- binding characteristics and antithrombotic and bleeding effects in rat and dog models of thrombosis/hemostasis .
6208739	0	ticlopidine	79,90	Beta-thromboglobulin	0,20	ticlopidine	Beta-thromboglobulin	MESH:D013988	5473	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|END_ENTITY	Beta-thromboglobulin and platelet_factor_4 in polycythemia patients treated by ticlopidine .
20081260	0	ticlopidine	43,54	CYP1A2	58,64	ticlopidine	CYP1A2	MESH:D013988	1544	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Effect of diethyldithiocarbamate -LRB- DDC -RRB- and ticlopidine on CYP1A2 activity and caffeine metabolism : an in vitro comparative study with human cDNA-expressed CYP1A2 and liver microsomes .
11764927	1	ticlopidine	122,133	CYP_2C19	110,118	ticlopidine	CYP 2C19	MESH:D013988	1557	Chemical	Gene	inactivation|nmod|START_ENTITY inactivation|nmod|END_ENTITY	Mechanism-based inactivation of CYP_2C19 by ticlopidine .
20069129	0	ticlopidine	76,87	TNF-alpha	91,100	ticlopidine	TNF-alpha	MESH:D013988	7124	Chemical	Gene	Reduction|nmod|START_ENTITY Reduction|nmod|END_ENTITY	Reduction of monocyte_chemoattractant_protein-1 and interleukin-8 levels by ticlopidine in TNF-alpha stimulated human umbilical vein endothelial cells .
6797089	0	ticlopidine	23,34	VIII	60,64	ticlopidine	VIII	MESH:D013988	1351	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|nsubj|effect	The in vitro effect of ticlopidine on fibrinogen and factor VIII binding to human platelets .
19845434	0	ticlopidine	74,85	cytochrome_P450_2C19	50,70	ticlopidine	cytochrome P450 2C19	MESH:D013988	1557	Chemical	Gene	Comparison|acl|START_ENTITY Comparison|nmod|END_ENTITY	Comparison of mechanism-based inhibition of human cytochrome_P450_2C19 by ticlopidine , clopidogrel , and prasugrel .
1859515	0	ticlopidine	78,89	fibrinogen	12,22	ticlopidine	fibrinogen	MESH:D013988	2244	Chemical	Gene	Decrease|nmod|START_ENTITY Decrease|nmod|END_ENTITY	Decrease of fibrinogen in patients with peripheral_atherosclerotic_disease by ticlopidine .
3232130	0	ticlopidine	21,32	fibrinogen	36,46	ticlopidine	fibrinogen	MESH:D013988	2244	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Long-term effects of ticlopidine on fibrinogen and haemorheology in patients with peripheral_arterial_disease .
4096744	0	ticlopidine	11,22	fibrinogen	32,42	ticlopidine	fibrinogen	MESH:D013988	2244	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of ticlopidine on blood fibrinogen and blood viscosity in peripheral_atherosclerotic_disease .
7992249	0	ticlopidine	9,20	fibrinogen	44,54	ticlopidine	fibrinogen	MESH:D013988	2244	Chemical	Gene	treatment|amod|START_ENTITY lower|nsubj|treatment lower|dobj|END_ENTITY	How does ticlopidine treatment lower plasma fibrinogen ?
8091447	0	ticlopidine	90,101	fibrinogen	17,27	ticlopidine	fibrinogen	MESH:D013988	2244	Chemical	Gene	concentration|nmod|START_ENTITY concentration|nsubj|Effect Effect|nmod|END_ENTITY	Effect of plasma fibrinogen concentration on the inhibition of platelet_aggregation after ticlopidine compared with aspirin .
8332965	0	ticlopidine	14,25	fibrinogen	38,48	ticlopidine	fibrinogen	MESH:D013988	2244	Chemical	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	The effect of ticlopidine upon plasma fibrinogen levels in patients undergoing suprapubic prostatectomy .
8865524	0	ticlopidine	42,53	fibrinogen	21,31	ticlopidine	fibrinogen	MESH:D013988	2244	Chemical	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	Modulation of plasma fibrinogen levels by ticlopidine in healthy volunteers and patients with stable angina_pectoris .
2914328	0	tienilic_acid	51,64	glutathione_S-transferase	14,39	tienilic acid	glutathione S-transferase	MESH:D013989	58962(Tax:10116)	Chemical	Gene	Effect|acl|START_ENTITY Effect|nmod|inhibitor inhibitor|amod|END_ENTITY	Effect of the glutathione_S-transferase inhibitor , tienilic_acid , on biliary excretion of sulphobromophthalein .
6662998	0	tienilic_acid	45,58	microsomal_epoxide_hydrolase	13,41	tienilic acid	microsomal epoxide hydrolase	MESH:D013989	25315(Tax:10116)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of microsomal_epoxide_hydrolase by tienilic_acid in the rat .
19284881	0	tifacogin	97,106	tissue_factor_pathway_inhibitor	64,95	tifacogin	tissue factor pathway inhibitor	null	7035	Chemical	Gene	assessment|appos|START_ENTITY assessment|nmod|END_ENTITY	A clinical evaluation committee assessment of recombinant human tissue_factor_pathway_inhibitor -LRB- tifacogin -RRB- in patients with severe community-acquired_pneumonia .
22381043	0	tilidine	95,103	CYP2C19	16,23	tilidine	CYP2C19	MESH:D013993	1557	Chemical	Gene	Contribution|nmod|START_ENTITY Contribution|nmod|END_ENTITY	Contribution of CYP2C19 and CYP3A4 to the formation of the active nortilidine from the prodrug tilidine .
19772488	0	tiliroside	57,67	Tyrosinase	0,10	tiliroside	Tyrosinase	MESH:C052083	22173(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|dobj|effect	Tyrosinase inhibitory effect and inhibitory mechanism of tiliroside from raspberry .
16761241	0	timolol	89,96	TNF-alpha	118,127	timolol	TNF-alpha	MESH:D013999	24835(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|release release|amod|END_ENTITY	Effects of antiglaucoma drugs GLC756 , a novel dopamine D2 agonist and D1 antagonist , and timolol on endotoxin-induced TNF-alpha release in serum of rats .
7075967	0	timolol	42,49	lysozyme	64,72	timolol	lysozyme	MESH:D013999	4069	Chemical	Gene	treatment|nmod|START_ENTITY influence|nmod|treatment END_ENTITY|nsubj|influence	The influence of long-term treatment with timolol on human tear lysozyme albumin content .
5974	0	timolol	32,39	renin	15,20	timolol	renin	MESH:D013999	24715(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|Suppression Suppression|nmod|END_ENTITY	Suppression of renin release by timolol .
60566	0	timolol	11,18	renin	72,77	timolol	renin	MESH:D013999	5972	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|compound|END_ENTITY	Effects of timolol and hydrochlorothiazide on blood-pressure and plasma renin activity .
9239406	10	tin_protoporphyrin-IX	1481,1502	HO-1	1465,1469	tin protoporphyrin-IX	iNOS	MESH:C032628	24599(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Treatment of sheared SMCs with the HO-1 inhibitor , tin_protoporphyrin-IX , blocked the antiaggregatory effect of the cells , whereas the iNOS inhibitor , methyl -- arginine , had no effect .
19183167	0	tiotropium	17,27	ADRB2	65,70	tiotropium	ADRB2	MESH:C079890	154	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Additive role of tiotropium in severe asthmatics and Arg16Gly in ADRB2 as a potential marker to predict response .
18804362	0	tiotropium	46,56	COPD	74,78	tiotropium	COPD	MESH:C079890	260431	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	Formoterol mono - and combination therapy with tiotropium in patients with COPD : a 6-month study .
19281075	0	tiotropium	50,60	COPD	64,68	tiotropium	COPD	MESH:C079890	260431	Chemical	Gene	analysis|nmod|START_ENTITY analysis|nmod|END_ENTITY	Safety , tolerability and risk benefit analysis of tiotropium in COPD .
19617284	0	tiotropium	12,22	COPD	61,65	tiotropium	COPD	MESH:C079890	260431	Chemical	Gene	Efficacy|nmod|START_ENTITY Efficacy|nmod|prevention prevention|nmod|exacerbations exacerbations|nmod|END_ENTITY	Efficacy of tiotropium in the prevention of exacerbations of COPD .
20714373	0	tiotropium	23,33	COPD	50,54	tiotropium	COPD	MESH:C079890	260431	Chemical	Gene	SMI|compound|START_ENTITY SMI|nmod|END_ENTITY	Efficacy and safety of tiotropium Respimat SMI in COPD in two 1-year randomized studies .
21887993	0	tiotropium	152,162	COPD	201,205	tiotropium	COPD	MESH:C079890	260431	Chemical	Gene	combination|nmod|START_ENTITY associated|dobj|combination associated|nmod|patients patients|nmod|END_ENTITY	Outcomes and costs associated with initial maintenance therapy with fluticasone_propionate-salmeterol_xinafoate 250 microg/50 microg combination versus tiotropium in commercially insured patients with COPD .
21992217	0	tiotropium	69,79	COPD	127,131	tiotropium	COPD	MESH:C079890	260431	Chemical	Gene	therapy|nmod|START_ENTITY analysis|nmod|therapy monotherapy|nsubj|analysis monotherapy|advcl|treating treating|dobj|END_ENTITY	Cost-effectiveness analysis of roflumilast/tiotropium therapy versus tiotropium monotherapy for treating severe-to-very severe COPD .
23490290	0	tiotropium	29,39	COPD	98,102	tiotropium	COPD	MESH:C079890	260431	Chemical	Gene	effectiveness|nmod|START_ENTITY effectiveness|nmod|prevention prevention|nmod|readmission readmission|nmod|END_ENTITY	Comparative effectiveness of tiotropium and ipratropium in prevention of hospital readmission for COPD : a population-based cohort study .
23596463	0	tiotropium	7,17	COPD	35,39	tiotropium	COPD	MESH:C079890	260431	Chemical	Gene	Use|nmod|START_ENTITY Use|nmod|END_ENTITY	Use of tiotropium in patients with COPD aged 80 years and older .
26894830	0	tiotropium_bromide	13,31	COPD	53,57	tiotropium bromide	COPD	MESH:C079890	260431	Chemical	Gene	START_ENTITY|nmod|treatment treatment|nmod|END_ENTITY	Olodaterol + tiotropium_bromide for the treatment of COPD .
18624980	0	tiplaxtinin	10,21	PAI-1	56,61	tiplaxtinin	PAI-1	MESH:C488103	24617(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Effect of tiplaxtinin -LRB- PAI-039 -RRB- , an orally bioavailable PAI-1 antagonist , in a rat model of thrombosis .
14691439	0	tirofiban	10,19	C-reactive_protein	23,41	tirofiban	C-reactive protein	CHEBI:9605	1401	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of tirofiban on C-reactive_protein in non-ST-elevation_myocardial_infarction .
15642557	0	tirofiban	11,20	C-reactive_protein	53,71	tirofiban	C-reactive protein	CHEBI:9605	1401	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of tirofiban and statins on high-sensitivity C-reactive_protein , interleukin-6 , and soluble CD40 ligand following percutaneous coronary interventions in patients with stable coronary_artery_disease .
9584421	0	titanium	60,68	Fibrinogen	1,11	titanium	Fibrinogen	MESH:D014025	2244	Chemical	Gene	affects|nmod|START_ENTITY affects|nsubj|END_ENTITY	-LSB- Fibrinogen affects blood and bone marrow cell functions on titanium in vitro -RSB- .
18956442	0	titanium	4,12	GIN1	50,54	titanium	GIN1	MESH:D014025	54826	Chemical	Gene	protein|compound|START_ENTITY protein|nmod|END_ENTITY	The titanium binding protein of Rhodococcus ruber GIN1 -LRB- NCIMB 40340 -RRB- is a cell-surface homolog of the cytosolic enzyme dihydrolipoamide_dehydrogenase .
20872576	5	titanium	563,571	IL-1b	580,585	titanium	NALP3	MESH:D014025	114548	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|secretion secretion|compound|END_ENTITY	We demonstrated that titanium induces IL-1b secretion from macrophages .
21633184	0	titanium	53,61	TNF-a	79,84	titanium	TNF-a	MESH:D014025	21926(Tax:10090)	Chemical	Gene	release|compound|START_ENTITY release|amod|END_ENTITY	Inhibitory effect of -LRB- - -RRB- - epigallocatechin_gallate on titanium particle-induced TNF-a release and in vivo osteolysis .
20413066	0	titanium	10,18	lipoprotein_lipase	22,40	titanium	lipoprotein lipase	MESH:D014025	24539(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	Effect of titanium on lipoprotein_lipase activity in vivo and in vitro .
24115593	0	titanium	17,25	p38	0,3	titanium	p38	MESH:D014025	26416(Tax:10090)	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	p38 signaling in titanium particle-induced MMP-2 secretion and activation in differentiating MC3T3-E1 cells .
24112737	0	titanium	78,86	phosphoinositide_3-kinase	12,37	titanium	phosphoinositide 3-kinase	MESH:D014025	298947(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of phosphoinositide_3-kinase in adhesion of oral epithelial cells to titanium .
16857255	0	titanium	55,63	phospholipase_D1	14,30	titanium	phospholipase D1	MESH:D014025	5337	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of phospholipase_D1 by surface roughness of titanium in MG63 osteoblast-like cell .
23858833	0	titanium_dioxide	48,64	ApoE	82,86	titanium dioxide	ApoE	MESH:C009495	11816(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|compound|END_ENTITY	Cardiovascular effects of pulmonary exposure to titanium_dioxide nanoparticles in ApoE knockout mice .
24215125	0	tivantinib	61,71	GSK3_alpha	0,10	tivantinib	GSK3 alpha	MESH:C551661	2931	Chemical	Gene	targets|nmod|START_ENTITY targets|nsubj|END_ENTITY	GSK3_alpha and beta are new functionally relevant targets of tivantinib in lung_cancer cells .
26891420	0	tivantinib	53,63	KRAS	180,184	tivantinib	KRAS	MESH:C551661	3845	Chemical	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	A randomized , placebo-controlled , phase 1/2 study of tivantinib -LRB- ARQ_197 -RRB- in combination with irinotecan and cetuximab in patients with metastatic colorectal_cancer with wild-type KRAS who have received first-line systemic therapy .
24260160	0	tivantinib	35,45	c-Met	19,24	tivantinib	c-Met	MESH:C551661	17295(Tax:10090)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Combination of the c-Met inhibitor tivantinib and zoledronic_acid prevents tumor bone engraftment and inhibits progression of established bone metastases in a breast xenograft model .
23701975	0	tivozanib	26,35	VEGF	45,49	tivozanib	VEGF	MESH:C553176	22339(Tax:10090)	Chemical	Gene	START_ENTITY|appos|receptor receptor|compound|END_ENTITY	Antiangiogenic effects of tivozanib , an oral VEGF receptor tyrosine kinase inhibitor , on experimental choroidal_neovascularization in mice .
26145469	0	tizol	61,66	lon	83,86	tizol	lon	null	9361	Chemical	Gene	Evaluation|nmod|START_ENTITY Evaluation|nmod|END_ENTITY	-LSB- Evaluation of the clinical efficacy of a new composition of tizol with triam in lon in complex treatment of patients with erosive ulcerous_form_of_lichen_planus_of_the_oral_mucosa -RSB- .
21414310	0	tobramycin	10,20	MUC5AC	57,63	tobramycin	MUC5AC	MESH:D014031	4586	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	High-dose tobramycin inhibits lipopolysaccharide-induced MUC5AC production in human lung epithelial cells .
7577399	0	tobramycin	82,92	adenosine_deaminase_binding_protein	21,56	tobramycin	adenosine deaminase binding protein	MESH:D014031	6462	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|excretion excretion|nmod|END_ENTITY	Urinary excretion of adenosine_deaminase_binding_protein in neonates treated with tobramycin .
7121122	0	tobramycin	10,20	pseudocholinesterase	30,50	tobramycin	pseudocholinesterase	MESH:D014031	590	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|compound|END_ENTITY	Effect of tobramycin on serum pseudocholinesterase levels .
14512521	0	tocopherol	54,64	homogentisate_phytyltransferase	12,43	tocopherol	homogentisate phytyltransferase	MESH:D024505	816412(Tax:3702)	Chemical	Gene	enzymes|compound|START_ENTITY enzymes|compound|END_ENTITY	The role of homogentisate_phytyltransferase and other tocopherol pathway enzymes in the regulation of tocopherol synthesis during abiotic stress .
2529919	0	tocopherol	39,49	rhodopsin	53,62	tocopherol	rhodopsin	MESH:D024505	6010	Chemical	Gene	Study|nmod|START_ENTITY Study|nmod|END_ENTITY	-LSB- Study of thermo-stabilizing effect of tocopherol on rhodopsin in the presence of fatty_acids using the method of differential scanning calorimetry -RSB- .
11451434	0	tocopherols	54,65	glutathione_S-transferase_P1-1	20,50	tocopherols	glutathione S-transferase P1-1	MESH:D024505	2950	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of human glutathione_S-transferase_P1-1 by tocopherols and alpha-tocopherol derivatives .
14970893	0	tocopherols	33,44	intercellular_adhesion_molecule-1	62,95	tocopherols	intercellular adhesion molecule-1	MESH:D024505	3383	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|cells cells|amod|END_ENTITY	-LSB- Effect of different isoforms of tocopherols on expression of intercellular_adhesion_molecule-1 in human umbilical vein endothelial cells -RSB- .
11287217	0	tocopheryl	14,24	carboxyl_ester_hydrolase	55,79	tocopheryl	carboxyl ester hydrolase	null	1056	Chemical	Gene	Hydrolysis|nmod|START_ENTITY Hydrolysis|nmod|END_ENTITY	Hydrolysis of tocopheryl and retinyl_esters by porcine carboxyl_ester_hydrolase is affected by their carboxylate moiety and bile_acids .
24768803	0	tocotrienol	80,91	Akt	29,32	tocotrienol	Akt	MESH:D024508	207	Chemical	Gene	effects|nmod|START_ENTITY mediates|dobj|effects mediates|nsubj|END_ENTITY	The estrogen_receptor b-PI3K / Akt pathway mediates the cytoprotective effects of tocotrienol in a cellular Parkinson 's _ disease model .
26315028	0	tocotrienol	6,17	SHP2	47,51	tocotrienol	SHP2	MESH:D024508	5781	Chemical	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Gamma tocotrienol targets tyrosine phosphatase SHP2 in mammospheres resulting in cell death through RAS/ERK pathway .
23526264	0	tocotrienol	11,22	tumor_necrosis_factor-a	26,49	tocotrienol	tumor necrosis factor-a	MESH:D024508	24835(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of tocotrienol on tumor_necrosis_factor-a / d-galactosamine-induced steatohepatitis in rats .
20823493	0	tocotrienols	54,66	NF-kappaB	8,17	tocotrienols	NF-kappaB	MESH:D024508	4790	Chemical	Gene	effects|nmod|START_ENTITY Role|nmod|effects Role|nmod|END_ENTITY	Role of NF-kappaB in the anti-inflammatory effects of tocotrienols .
24041758	0	tocotrienols	22,34	TGF-b	123,128	tocotrienols	TGF-b	MESH:D024508	59086(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|amod|END_ENTITY	Protective effects of tocotrienols against lipid-induced nephropathy in experimental type-2 diabetic rats by modulation in TGF-b expression .
22889351	0	tofogliflozin	13,26	SGLT2	140,145	tofogliflozin	SGLT2	MESH:C575086	6524	Chemical	Gene	START_ENTITY|nmod|sodium_glucose sodium_glucose|appos|END_ENTITY	Discovery of tofogliflozin , a novel C-arylglucoside with an O-spiroketal ring system , as a highly selective sodium_glucose cotransporter 2 -LRB- SGLT2 -RRB- inhibitor for the treatment of type 2 diabetes .
23249697	0	tofogliflozin	30,43	SGLT2	10,15	tofogliflozin	SGLT2	MESH:C575086	64522(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY END_ENTITY|acl|inhibition	Selective SGLT2 inhibition by tofogliflozin reduces renal glucose reabsorption under hyperglycemic but not under hypo - or euglycemic conditions in rats .
24074237	0	tofogliflozin	47,60	SGLT2	31,36	tofogliflozin	SGLT2	MESH:C575086	6524	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|balance balance|nmod|END_ENTITY	Metabolism and mass balance of SGLT2 inhibitor tofogliflozin following oral administration to humans .
6759232	0	tolbutamide	92,103	Insulin	0,7	tolbutamide	Insulin	MESH:D014044	3630	Chemical	Gene	infusion|amod|START_ENTITY nonglucose|nmod|infusion responses|xcomp|nonglucose responses|nsubj|END_ENTITY	Insulin responses to nonglucose stimuli in non-insulin-dependent_diabetes_mellitus during a tolbutamide infusion .
7041329	0	tolbutamide	45,56	Insulin	0,7	tolbutamide	Insulin	MESH:D014044	3630	Chemical	Gene	START_ENTITY|nsubj|response response|compound|END_ENTITY	Insulin response to glucagon with or without tolbutamide in normal and diabetic subjects .
835136	0	tolbutamide	89,100	Insulin	0,7	tolbutamide	Insulin	MESH:D014044	3630	Chemical	Gene	injected|nmod|START_ENTITY injected|nsubj|response response|compound|END_ENTITY	Insulin response to glucose or glucagon in subclinical diabetes previously injected with tolbutamide .
10526167	0	tolbutamide	4,15	SUR1	24,28	tolbutamide	SUR1	MESH:D014044	6833	Chemical	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	The tolbutamide site of SUR1 and a mechanism for its functional coupling to K -LRB- ATP -RRB- channel closure .
1237421	0	tolbutamide	78,89	insulin	22,29	tolbutamide	insulin	MESH:D014044	3630	Chemical	Gene	dose|nmod|START_ENTITY administration|nmod|dose immunoreactive|nmod|administration immunoreactive|dobj|END_ENTITY	-LSB- Serum immunoreactive insulin after the oral administration of single dose of tolbutamide .
1237422	0	tolbutamide	78,89	insulin	22,29	tolbutamide	insulin	MESH:D014044	483665(Tax:9615)	Chemical	Gene	dose|nmod|START_ENTITY administration|nmod|dose immunoreactive|nmod|administration immunoreactive|dobj|END_ENTITY	-LSB- Serum immunoreactive insulin after the oral administration of single dose of tolbutamide .
15082027	0	tolbutamide	20,31	insulin	58,65	tolbutamide	insulin	MESH:D014044	3630	Chemical	Gene	START_ENTITY|dobj|secretion secretion|compound|END_ENTITY	Chronic exposure to tolbutamide and glibenclamide impairs insulin secretion but not transcription of K -LRB- ATP -RRB- channel components .
15787664	0	tolbutamide	30,41	insulin	10,17	tolbutamide	insulin	MESH:D014044	3630	Chemical	Gene	Preserved|xcomp|START_ENTITY Preserved|dobj|response response|compound|END_ENTITY	Preserved insulin response to tolbutamide in hepatocyte nuclear factor-1alpha mutation carriers .
2183445	0	tolbutamide	56,67	insulin	27,34	tolbutamide	insulin	MESH:D014044	3630	Chemical	Gene	concentration|compound|START_ENTITY effect|nmod|concentration inhibition|dep|effect inhibition|nmod|secretion secretion|compound|END_ENTITY	Cyclosporine inhibition of insulin secretion : effect of tolbutamide and extracellular calcium concentration .
32082	1	tolbutamide	102,113	insulin	70,77	tolbutamide	insulin	MESH:D014044	3630	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Plasma insulin response to intravenous tolbutamide -LRB- author 's transl -RRB- -RSB- .
3301482	0	tolbutamide	81,92	insulin	40,47	tolbutamide	insulin	MESH:D014044	3630	Chemical	Gene	sensitivity|nmod|START_ENTITY sensitivity|compound|END_ENTITY	Derivation of a quantitative measure of insulin sensitivity from the intravenous tolbutamide test using the minimal model of glucose dynamics .
4150009	0	tolbutamide	37,48	insulin	16,23	tolbutamide	insulin	MESH:D014044	3630	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Stimulation Stimulation|nmod|END_ENTITY	-LSB- Stimulation of insulin secretion by tolbutamide .
5641614	0	tolbutamide	103,114	insulin	56,63	tolbutamide	insulin	MESH:D014044	3630	Chemical	Gene	decreased|nmod|START_ENTITY decreased|dobj|END_ENTITY	Elevated serum human growth_hormone and decreased serum insulin in prediabetic males after intravenous tolbutamide and glucose .
617112	0	tolbutamide	45,56	insulin	19,26	tolbutamide	insulin	MESH:D014044	3630	Chemical	Gene	Response|nmod|START_ENTITY Response|nmod|END_ENTITY	Response of plasma insulin to small doses of tolbutamide in obesity and acromegaly .
6354209	0	tolbutamide	95,106	insulin	69,76	tolbutamide	insulin	MESH:D014044	3630	Chemical	Gene	responsiveness|xcomp|START_ENTITY responsiveness|csubj|-LSB- -LSB-|dobj|structure structure|dep|changes changes|nmod|END_ENTITY	-LSB- 1 -RRB- Temporal structure of endocrine secretion : circannual changes in insulin responsiveness to tolbutamide in man -RSB- .
6991327	0	tolbutamide	73,84	insulin	16,23	tolbutamide	insulin	MESH:D014044	3630	Chemical	Gene	nonglucose|nmod|START_ENTITY secretion|xcomp|nonglucose secretion|nsubj|Potentiation Potentiation|nmod|END_ENTITY	Potentiation of insulin secretion to nonglucose stimuli in normal man by tolbutamide .
7018888	0	tolbutamide	14,25	insulin	52,59	tolbutamide	insulin	MESH:D014044	483665(Tax:9615)	Chemical	Gene	extraction|amod|START_ENTITY effect|nmod|extraction effect|nmod|END_ENTITY	The effect of tolbutamide and hepatic extraction of insulin and glucagon and hepatic_glucose_output in anesthetized dogs .
794823	0	tolbutamide	93,104	insulin	22,29	tolbutamide	insulin	MESH:D014044	3630	Chemical	Gene	-RSB-|amod|START_ENTITY followed|nmod|-RSB- test|acl|followed test|dep|-LSB- -LSB-|dobj|method method|acl|studying studying|dobj|secretion secretion|compound|END_ENTITY	-LSB- A method of studying insulin secretion in humans : the glucose stimulation test , followed by tolbutamide -RSB- .
8027255	0	tolbutamide	84,95	insulin	103,110	tolbutamide	insulin	MESH:D014044	3630	Chemical	Gene	START_ENTITY|nmod|infusion infusion|compound|END_ENTITY	A new method for comparing portal and peripheral venous insulin delivery in humans : tolbutamide versus insulin infusion .
8027255	0	tolbutamide	84,95	insulin	56,63	tolbutamide	insulin	MESH:D014044	3630	Chemical	Gene	method|dep|START_ENTITY method|dep|delivery delivery|compound|END_ENTITY	A new method for comparing portal and peripheral venous insulin delivery in humans : tolbutamide versus insulin infusion .
942132	0	tolbutamide	11,22	insulin	36,43	tolbutamide	insulin	MESH:D014044	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of tolbutamide on plasmatic insulin and glucose in children treated with diphenylhydantoin -LRB- author 's transl -RRB- -RSB- .
8384841	0	tolbutamide	25,36	phosphoenolpyruvate_carboxykinase	40,73	tolbutamide	phosphoenolpyruvate carboxykinase	MESH:D014044	362282(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|amod|END_ENTITY	The inhibitory effect of tolbutamide on phosphoenolpyruvate_carboxykinase activity in rat hepatoma H4IIE cells .
219704	0	tolbutamide	10,21	renin	32,37	tolbutamide	renin	MESH:D014044	24715(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|compound|END_ENTITY	Effect of tolbutamide on plasma renin activity .
10343151	0	tolcapone	19,28	COMT	0,4	tolcapone	COMT	MESH:C066340	1312	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	COMT inhibition by tolcapone further improves levodopa pharmacokinetics when combined with a dual-release formulation of levodopa/benserazide .
10510160	0	tolcapone	21,30	COMT	0,4	tolcapone	COMT	MESH:C066340	1312	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	COMT inhibition with tolcapone does not affect carbidopa pharmacokinetics in parkinsonian patients in levodopa/carbidopa -LRB- Sinemet -RRB- .
10895397	0	tolcapone	73,82	COMT	25,29	tolcapone	COMT	MESH:C066340	1312	Chemical	Gene	relationship|nmod|START_ENTITY relationship|nmod|genotype genotype|amod|END_ENTITY	The relationship between COMT genotype and the clinical effectiveness of tolcapone , a COMT inhibitor , in patients with Parkinson 's _ disease .
10895397	0	tolcapone	73,82	COMT	86,90	tolcapone	COMT	MESH:C066340	1312	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	The relationship between COMT genotype and the clinical effectiveness of tolcapone , a COMT inhibitor , in patients with Parkinson 's _ disease .
11793426	0	tolcapone	27,36	COMT	55,59	tolcapone	COMT	MESH:C066340	1312	Chemical	Gene	evidence|acl:relcl|START_ENTITY acts|nsubj|evidence acts|nmod|inhibitor inhibitor|compound|END_ENTITY	18F-dopa PET evidence that tolcapone acts as a central COMT inhibitor in Parkinson 's _ disease .
18728767	0	tolcapone	21,30	COMT	0,4	tolcapone	COMT	MESH:C066340	1312	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	COMT inhibition with tolcapone in the treatment algorithm of patients with Parkinson 's _ disease -LRB- PD -RRB- : relevance for motor and non-motor features .
23953269	0	tolcapone	28,37	COMT	84,88	tolcapone	COMT	MESH:C066340	1312	Chemical	Gene	study|nmod|START_ENTITY proof|nmod|study proof|dep|relationships relationships|nmod|genotype genotype|amod|END_ENTITY	A proof of concept study of tolcapone for pathological gambling : relationships with COMT genotype and brain activation .
26037113	0	tolcapone	54,63	COMT	45,49	tolcapone	COMT	MESH:C066340	1312	Chemical	Gene	transferase|nmod|START_ENTITY transferase|appos|END_ENTITY	Inhibition of catechol-O-methyl transferase -LRB- COMT -RRB- by tolcapone restores reductions in microtubule-associated protein 2 -LRB- MAP2 -RRB- and synaptophysin -LRB- SYP -RRB- following exposure of neuronal cells to neurotropic HIV .
26919286	0	tolcapone	56,65	COMT	36,40	tolcapone	COMT	MESH:C066340	24267(Tax:10116)	Chemical	Gene	memory_deficits|amod|START_ENTITY inhibition|nmod|memory_deficits inhibition|nsubj|catechol-O-methyltransferase catechol-O-methyltransferase|appos|END_ENTITY	Brain catechol-O-methyltransferase -LRB- COMT -RRB- inhibition by tolcapone counteracts recognition memory_deficits in normal and chronic phencyclidine-treated rats and in COMT-Val transgenic_mice .
8879148	0	tolcapone	24,33	COMT	84,88	tolcapone	COMT	MESH:C066340	1312	Chemical	Gene	scaling|nmod|START_ENTITY scaling|dobj|inhibitor inhibitor|appos|END_ENTITY	Interspecies scaling of tolcapone , a new inhibitor of catechol-O-methyltransferase -LRB- COMT -RRB- .
9252801	0	tolcapone	33,42	COMT	14,18	tolcapone	COMT	MESH:C066340	1312	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|effect effect|nmod|END_ENTITY	The effect of COMT inhibition by tolcapone on tolerability and pharmacokinetics of different levodopa/benserazide formulations .
9404535	0	tolcapone	22,31	COMT	1,5	tolcapone	COMT	MESH:C066340	1312	Chemical	Gene	-RSB-|amod|START_ENTITY inhibition|nmod|-RSB- inhibition|nsubj|END_ENTITY	-LSB- COMT inhibition with tolcapone -RSB- .
9343116	0	tolcapone	45,54	Catechol-O-methyltransferase	0,28	tolcapone	Catechol-O-methyltransferase	MESH:C066340	1312	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Catechol-O-methyltransferase inhibition with tolcapone reduces the `` wearing off '' phenomenon and levodopa requirements in fluctuating parkinsonian patients .
9591522	0	tolcapone	45,54	Catechol-O-methyltransferase	0,28	tolcapone	Catechol-O-methyltransferase	MESH:C066340	1312	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Catechol-O-methyltransferase inhibition with tolcapone reduces the `` wearing off '' phenomenon and levodopa requirements in fluctuating parkinsonian patients .
10323260	0	tolcapone	10,19	catechol-O-methyltransferase	23,51	tolcapone	catechol-O-methyltransferase	MESH:C066340	24267(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effect of tolcapone , a catechol-O-methyltransferase inhibitor , on striatal dopaminergic transmission during blockade of dopamine uptake .
10583021	0	tolcapone	28,37	catechol-O-methyltransferase	60,88	tolcapone	catechol-O-methyltransferase	MESH:C066340	1312	Chemical	Gene	Metabolism|nmod|START_ENTITY Metabolism|appos|inhibitor inhibitor|nmod|END_ENTITY	Metabolism and excretion of tolcapone , a novel inhibitor of catechol-O-methyltransferase .
26919286	0	tolcapone	56,65	catechol-O-methyltransferase	6,34	tolcapone	catechol-O-methyltransferase	MESH:C066340	24267(Tax:10116)	Chemical	Gene	memory_deficits|amod|START_ENTITY inhibition|nmod|memory_deficits inhibition|nsubj|END_ENTITY	Brain catechol-O-methyltransferase -LRB- COMT -RRB- inhibition by tolcapone counteracts recognition memory_deficits in normal and chronic phencyclidine-treated rats and in COMT-Val transgenic_mice .
7737328	0	tolcapone	11,20	catechol-O-methyltransferase	30,58	tolcapone	catechol-O-methyltransferase	MESH:C066340	24267(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effects of tolcapone , a novel catechol-O-methyltransferase inhibitor , on striatal metabolism of L-dopa and dopamine in rats .
8821542	0	tolcapone	82,91	catechol-O-methyltransferase	38,66	tolcapone	catechol-O-methyltransferase	MESH:C066340	24267(Tax:10116)	Chemical	Gene	sensitivity|xcomp|START_ENTITY sensitivity|nsubj|aspects aspects|nmod|END_ENTITY	Ontogenic aspects of liver and kidney catechol-O-methyltransferase sensitivity to tolcapone .
8829199	0	tolcapone	16,25	catechol-O-methyltransferase	29,57	tolcapone	catechol-O-methyltransferase	MESH:C066340	24267(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Minor effect of tolcapone , a catechol-O-methyltransferase inhibitor , on extracellular dopamine levels modified by amphetamine or pargyline : a microdialysis study in anaesthetized rats .
8879148	0	tolcapone	24,33	catechol-O-methyltransferase	54,82	tolcapone	catechol-O-methyltransferase	MESH:C066340	1312	Chemical	Gene	scaling|nmod|START_ENTITY scaling|dobj|inhibitor inhibitor|nmod|END_ENTITY	Interspecies scaling of tolcapone , a new inhibitor of catechol-O-methyltransferase -LRB- COMT -RRB- .
9203084	0	tolcapone	11,20	catechol-O-methyltransferase	24,52	tolcapone	catechol-O-methyltransferase	MESH:C066340	1312	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effects of tolcapone , a catechol-O-methyltransferase inhibitor , on motor symptoms and pharmacokinetics of levodopa in patients with Parkinson 's _ disease .
9262345	0	tolcapone	39,48	catechol-O-methyltransferase	100,128	tolcapone	catechol-O-methyltransferase	MESH:C066340	24267(Tax:10116)	Chemical	Gene	inhibition|amod|START_ENTITY nature|nmod|inhibition Studies|nmod|nature END_ENTITY|nsubj|Studies	Studies on the tight-binding nature of tolcapone inhibition of soluble and membrane-bound rat brain catechol-O-methyltransferase .
9088998	0	tolfenamic_acid	7,22	glucose-6-phosphate_dehydrogenase	60,93	tolfenamic acid	glucose-6-phosphate dehydrogenase	MESH:C009500	2539	Chemical	Gene	START_ENTITY|nmod|deficiency deficiency|amod|END_ENTITY	Use of tolfenamic_acid in febrile children with and without glucose-6-phosphate_dehydrogenase deficiency .
23864386	0	tolfenamic_acid	58,73	transforming_growth_factor-b	18,46	tolfenamic acid	transforming growth factor-b	MESH:C009500	7040	Chemical	Gene	pathway|nmod|START_ENTITY pathway|amod|END_ENTITY	Disruption of the transforming_growth_factor-b pathway by tolfenamic_acid via the ERK MAP kinase pathway .
7944563	0	toluene	48,55	ALDH2	0,5	toluene	ALDH2	MESH:D014050	217	Chemical	Gene	polymorphism|nmod|START_ENTITY polymorphism|compound|END_ENTITY	ALDH2 polymorphism and biological monitoring of toluene .
9253143	0	toluene	59,66	Cytochrome_P450	0,15	toluene	Cytochrome P450	MESH:D014050	4051	Chemical	Gene	metabolism|nmod|START_ENTITY responsible|nmod|metabolism isozymes|xcomp|responsible isozymes|nsubj|END_ENTITY	Cytochrome_P450 isozymes responsible for the metabolism of toluene and styrene in human liver microsomes .
22074881	0	toluene	77,84	c-Fos	16,21	toluene	c-Fos	MESH:D014050	314322(Tax:10116)	Chemical	Gene	inhalation|compound|START_ENTITY Distribution|nmod|inhalation Distribution|nmod|immunoreactivity immunoreactivity|amod|END_ENTITY	Distribution of c-Fos immunoreactivity in the rat brain following abuse-like toluene vapor inhalation .
24036183	0	toluene	9,16	c-Fos	36,41	toluene	c-Fos	MESH:D014050	2353	Chemical	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	Repeated toluene exposure increases c-Fos in catecholaminergic cells of the nucleus accumbens shell .
15129551	0	toluene	104,111	cytochrome_P-450_2E1	76,96	toluene	cytochrome P-450 2E1	MESH:D014050	25086(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	The metabolic rate constants and specific activity of human and rat hepatic cytochrome_P-450_2E1 toward toluene and chloroform .
1994898	0	toluene	90,97	cytochrome_P450	49,64	toluene	cytochrome P450	MESH:D014050	25251(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY responsible|nmod|metabolism isozymes|xcomp|responsible isozymes|nsubj|characterization characterization|nmod|END_ENTITY	Monoclonal antibody-directed characterization of cytochrome_P450 isozymes responsible for toluene metabolism in rat liver .
8347164	0	toluene	43,50	cytochrome_P450	76,91	toluene	cytochrome P450	MESH:D014050	25251(Tax:10116)	Chemical	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Monoclonal antibody-directed assessment of toluene induction of rat hepatic cytochrome_P450 isozymes .
16581535	0	toluene	13,20	cytochrome_P450_2E1	38,57	toluene	cytochrome P450 2E1	MESH:D014050	1571	Chemical	Gene	exposure|compound|START_ENTITY induces|nsubj|exposure induces|dobj|expression expression|amod|END_ENTITY	Occupational toluene exposure induces cytochrome_P450_2E1 mRNA expression in peripheral lymphocytes .
3385045	0	toluidine	4,13	aid	28,31	toluidine	aid	null	57379	Chemical	Gene	test|amod|START_ENTITY test|dep|END_ENTITY	The toluidine blue test : an aid in the diagnosis and treatment of early squamous_cell_carcinomas of mucous membranes .
15113814	0	tolvaptan	11,20	vasopressin	24,35	tolvaptan	vasopressin	MESH:C116664	551	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|antagonist antagonist|compound|END_ENTITY	Effects of tolvaptan , a vasopressin antagonist , in patients hospitalized with worsening heart_failure : a randomized controlled trial .
17384438	0	tolvaptan	31,40	vasopressin	50,61	tolvaptan	vasopressin	MESH:C116664	551	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Short-term clinical effects of tolvaptan , an oral vasopressin antagonist , in patients hospitalized for heart_failure : the EVEREST Clinical Status Trials .
16313114	0	tongxinluo	11,21	endothelin-1	25,37	tongxinluo	endothelin-1	MESH:C513941	396915(Tax:9823)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Effect of tongxinluo on endothelin-1 in the mini-swine model of acute_myocardial_infarction and reperfusion -RSB- .
19730994	0	topiramate	23,33	P-glycoprotein	59,73	topiramate	P-glycoprotein	MESH:C052342	5243	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	The antiepileptic drug topiramate is a substrate for human P-glycoprotein but not multidrug resistance proteins .
18947474	0	topiramate	55,65	P300	40,44	topiramate	P300	MESH:C052342	2033	Chemical	Gene	treatment|amod|START_ENTITY END_ENTITY|nmod|treatment	-LSB- Changes of the event related potential P300 following topiramate treatment in children with epilepsy -RSB- .
19148780	0	topiramate	15,25	caspase-3	29,38	topiramate	caspase-3	MESH:C052342	25402(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	The effects of topiramate on caspase-3 expression in hippocampus of basolateral amygdala -LRB- BLA -RRB- electrical kindled epilepsy rat .
24348794	0	topiramate	10,20	interleukin_6	24,37	topiramate	interleukin 6	MESH:C052342	24498(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of topiramate on interleukin_6 expression in the hippocampus of amygdala-kindled epileptic rats .
14658948	0	topiramate	34,44	part_1	102,108	topiramate	part 1	MESH:C052342	25859	Chemical	Gene	START_ENTITY|nmod|trial trial|appos|END_ENTITY	Treatment of bulimia_nervosa with topiramate in a randomized , double-blind , placebo-controlled trial , part_1 : improvement in binge and purge measures .
26589240	0	topiroxostat	88,100	xanthine_oxidoreductase	110,133	topiroxostat	xanthine oxidoreductase	MESH:C504882	497811(Tax:10116)	Chemical	Gene	treatment|nmod|START_ENTITY decrease|nmod|treatment END_ENTITY|ccomp|decrease	Uricosuric agents decrease the plasma urate level in rats by concomitant treatment with topiroxostat , a novel xanthine_oxidoreductase inhibitor .
14726661	0	topotecan	20,29	G-CSF	56,61	topotecan	G-CSF	MESH:D019772	1440	Chemical	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	A phase II study of topotecan and cyclophosphamide with G-CSF in patients with advanced small_cell_lung_cancer .
25002722	0	topotecan	71,80	S0802	25,30	topotecan	S0802	MESH:D019772	1077218(Tax:198215)	Chemical	Gene	trial|nmod|START_ENTITY END_ENTITY|dep|trial	Southwest Oncology Group S0802 : a randomized , phase II trial of weekly topotecan with and without ziv-aflibercept in patients with platinum-treated small-cell_lung_cancer .
12089223	0	topotecan	34,43	breast_cancer_resistance_protein	68,100	topotecan	breast cancer resistance protein	MESH:D019772	9429	Chemical	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	Increased oral bioavailability of topotecan in combination with the breast_cancer_resistance_protein and P-glycoprotein inhibitor GF120918 .
23024792	0	topotecan	99,108	p53	92,95	topotecan	p53	MESH:D019772	7157	Chemical	Gene	treatment|compound|START_ENTITY END_ENTITY|nmod|treatment	The inhibition of autophagy sensitises colon_cancer cells with wild-type p53 but not mutant p53 to topotecan treatment .
18854562	0	topotecan	51,60	small-cell_lung_cancer	97,119	topotecan	small-cell lung cancer	MESH:D019772	7864	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	Randomized phase II trial comparing amrubicin with topotecan in patients with previously treated small-cell_lung_cancer : North Japan Lung_Cancer Study Group Trial 0402 .
17325387	0	torcetrapib	31,42	CETP	14,18	torcetrapib	CETP	MESH:C483909	100327267(Tax:9986)	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Inhibition of CETP activity by torcetrapib reduces susceptibility to diet-induced atherosclerosis in New Zealand White rabbits .
16574893	0	torcetrapib	60,71	apolipoprotein_B100	75,94	torcetrapib	apolipoprotein B100	MESH:C483909	338	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|metabolism metabolism|amod|END_ENTITY	Effects of the cholesteryl_ester_transfer_protein inhibitor torcetrapib on apolipoprotein_B100 metabolism in humans .
17084249	0	torcetrapib	23,34	cholesteryl_ester_transfer_protein	44,78	torcetrapib	cholesteryl ester transfer protein	MESH:C483909	1071	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Efficacy and safety of torcetrapib , a novel cholesteryl_ester_transfer_protein inhibitor , in individuals with below-average high-density lipoprotein cholesterol levels .
24380613	0	torcetrapib	118,129	cholesteryl_ester_transfer_protein	66,100	torcetrapib	cholesteryl ester transfer protein	MESH:C483909	1071	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|Identification Identification|nmod|variant variant|nmod|END_ENTITY	Identification of a novel , non-tetrahydroquinoline variant of the cholesteryl_ester_transfer_protein -LRB- CETP -RRB- inhibitor torcetrapib , with improved aqueous solubility .
8798584	0	tosylphenylalanine_chloromethyl_ketone	32,70	serine_protease	4,19	tosylphenylalanine chloromethyl ketone	serine protease	null	2147	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	The serine_protease inhibitors , tosylphenylalanine_chloromethyl_ketone and tosyllysine_chloromethyl_ketone , potently inhibit pp70s6k activation .
17591067	0	trafermin	42,51	basic_fibroblast_growth_factor	10,40	trafermin	basic fibroblast growth factor	MESH:C114444	2247	Chemical	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of basic_fibroblast_growth_factor , trafermin , on entero-related fistulae , report of two cases .
15777775	0	tramadol	69,77	5-HT1A	8,14	tramadol	5-HT1A	MESH:D014147	15550(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY Role|nmod|effect Role|nmod|END_ENTITY	Role of 5-HT1A and 5-HT1B_receptors in the antinociceptive effect of tramadol .
16832657	0	tramadol	101,109	5-HT1A	21,27	tramadol	5-HT1A	MESH:D014147	15550(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY role|nmod|effect role|nmod|END_ENTITY	Differential role of 5-HT1A and 5-HT1B_receptors on the antinociceptive and antidepressant effect of tramadol in mice .
3927766	0	tramadol	11,19	CO2	35,38	tramadol	CO2	MESH:D014147	717	Chemical	Gene	START_ENTITY|nmod|response response|compound|END_ENTITY	-LSB- Effect of tramadol on ventilatory CO2 response and mouth occlusion pressure -RSB- .
11808821	0	tramadol	20,28	CYP2D6	93,99	tramadol	CYP2D6	MESH:D014147	1565	Chemical	Gene	ratios|amod|START_ENTITY Concordance|nmod|ratios Concordance|dep|influence influence|nmod|END_ENTITY	Concordance between tramadol and dextromethorphan parent/metabolite ratios : the influence of CYP2D6 and non-CYP2D6 pathways on biotransformation .
12893130	0	tramadol	94,102	CYP2D6	28,34	tramadol	CYP2D6	MESH:D014147	1565	Chemical	Gene	drug|dep|START_ENTITY correlation|nmod|drug metabolite|nsubj|correlation reveals|ccomp|metabolite reveals|nsubj|analysis analysis|nmod|gene gene|compound|END_ENTITY	Post-mortem SNP analysis of CYP2D6 gene reveals correlation between genotype and opioid drug -LRB- tramadol -RRB- metabolite ratios in blood .
14499440	0	tramadol	43,51	CYP2D6	10,16	tramadol	CYP2D6	MESH:D014147	1565	Chemical	Gene	analgesia|amod|START_ENTITY genotype|nmod|analgesia genotype|nsubj|Impact Impact|nmod|END_ENTITY	Impact of CYP2D6 genotype on postoperative tramadol analgesia .
14624403	0	tramadol	74,82	CYP2D6	19,25	tramadol	CYP2D6	MESH:D014147	1565	Chemical	Gene	study|nmod|START_ENTITY assay|dep|study assay|compound|END_ENTITY	A rapid and simple CYP2D6 genotyping assay -- case study with the analgetic tramadol .
16368820	0	tramadol	24,32	CYP2D6	98,104	tramadol	CYP2D6	MESH:D014147	1565	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The analgesic effect of tramadol after intravenous injection in healthy volunteers in relation to CYP2D6 .
16497087	0	tramadol	17,25	CYP2D6	43,49	tramadol	CYP2D6	MESH:D014147	1565	Chemical	Gene	action|nmod|START_ENTITY determined|nsubjpass|action determined|nmod|genotype genotype|compound|END_ENTITY	Miotic action of tramadol is determined by CYP2D6 genotype .
16763825	0	tramadol	37,45	CYP2D6	49,55	tramadol	CYP2D6	MESH:D014147	1565	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY pharmacokinetics|nmod|metabolizers metabolizers|nummod|END_ENTITY	Enantioselective pharmacokinetics of tramadol in CYP2D6 extensive and poor metabolizers .
16960721	0	tramadol	60,68	CYP2D6	14,20	tramadol	CYP2D6	MESH:D014147	1565	Chemical	Gene	analgesia|amod|START_ENTITY *|nmod|analgesia *|nsubj|Effect Effect|nmod|END_ENTITY	Effect of the CYP2D6 * 10 C188T polymorphism on postoperative tramadol analgesia in a Chinese population .
17175164	0	tramadol	20,28	CYP2D6	97,103	tramadol	CYP2D6	MESH:D014147	1565	Chemical	Gene	enantiomers|amod|START_ENTITY Pharmacokinetics|nmod|enantiomers metabolites|nsubj|Pharmacokinetics metabolites|nmod|phenotype phenotype|compound|END_ENTITY	Pharmacokinetics of tramadol enantiomers and their respective phase I metabolites in relation to CYP2D6 phenotype .
17361124	0	tramadol	18,26	CYP2D6	76,82	tramadol	CYP2D6	MESH:D014147	1565	Chemical	Gene	Concentrations|nmod|START_ENTITY enantiomers|nsubj|Concentrations enantiomers|nmod|genotypes genotypes|compound|END_ENTITY	Concentrations of tramadol and O-desmethyltramadol enantiomers in different CYP2D6 genotypes .
17570739	0	tramadol	41,49	CYP2D6	10,16	tramadol	CYP2D6	MESH:D014147	1565	Chemical	Gene	pharmacokinetics|amod|START_ENTITY Impact|nmod|pharmacokinetics Impact|nmod|polymorphism polymorphism|compound|END_ENTITY	Impact of CYP2D6 genetic polymorphism on tramadol pharmacokinetics and pharmacodynamics .
18204346	0	tramadol	87,95	CYP2D6	15,21	tramadol	CYP2D6	MESH:D014147	1565	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY duplication|nmod|pharmacokinetics duplication|nsubj|Effects Effects|nmod|gene gene|compound|END_ENTITY	Effects of the CYP2D6 gene duplication on the pharmacokinetics and pharmacodynamics of tramadol .
18520597	0	tramadol	35,43	CYP2D6	0,6	tramadol	CYP2D6	MESH:D014147	1565	Chemical	Gene	metabolism|amod|START_ENTITY relation|nmod|metabolism polymorphism|nmod|relation polymorphism|compound|END_ENTITY	CYP2D6 polymorphism in relation to tramadol metabolism : a study of faroese patients .
18640130	0	tramadol	34,42	CYP2D6	70,76	tramadol	CYP2D6	MESH:D014147	1565	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY pharmacokinetics|nmod|difference difference|nmod|metabolizers metabolizers|nummod|END_ENTITY	Modelling the pharmacokinetics of tramadol : on the difference between CYP2D6 extensive and poor metabolizers .
20354688	0	tramadol	79,87	CYP2D6	110,116	tramadol	CYP2D6	MESH:D014147	1565	Chemical	Gene	O-demethylation|nmod:poss|START_ENTITY O-demethylation|nmod|END_ENTITY	Two separate dose-dependent effects of paroxetine : mydriasis and inhibition of tramadol 's O-demethylation via CYP2D6 .
20456744	0	tramadol	73,81	CYP2D6	16,22	tramadol	CYP2D6	MESH:D014147	1565	Chemical	Gene	Relationship|nmod|START_ENTITY Relationship|nmod|polymorphisms polymorphisms|nummod|END_ENTITY	Relationship of CYP2D6 genetic polymorphisms and the pharmacokinetics of tramadol in Chinese volunteers .
21691803	0	tramadol	11,19	CYP2D6	40,46	tramadol	CYP2D6	MESH:D014147	1565	Chemical	Gene	START_ENTITY|nmod|metabolizer metabolizer|compound|END_ENTITY	Near-fatal tramadol cardiotoxicity in a CYP2D6 ultrarapid metabolizer .
25948472	0	tramadol	69,77	CYP2D6	14,20	tramadol	CYP2D6	MESH:D014147	1565	Chemical	Gene	patients|amod|START_ENTITY analgesia|nmod|patients polymorphism|nmod|analgesia polymorphism|nsubj|Effect Effect|nmod|gene gene|compound|END_ENTITY	Effect of the CYP2D6 gene polymorphism on postoperative analgesia of tramadol in Han nationality nephrectomy patients .
8988065	0	tramadol	26,34	CYP2D6	50,56	tramadol	CYP2D6	MESH:D014147	1565	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The hypoalgesic effect of tramadol in relation to CYP2D6 .
9476037	0	tramadol	68,76	CYP2D6	12,18	tramadol	CYP2D6	MESH:D014147	1565	Chemical	Gene	O-demethylation|nmod|START_ENTITY mediates|dobj|O-demethylation mediates|nsubj|END_ENTITY	Polymorphic CYP2D6 mediates O-demethylation of the opioid analgesic tramadol .
17401159	0	tramadol	47,55	prodynorphin	59,71	tramadol	prodynorphin	MESH:D014147	29190(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effects of prolonged treatment with the opiate tramadol on prodynorphin gene expression in rat CNS .
14636839	0	tramadol	11,19	substance_P	56,67	tramadol	substance P	MESH:D014147	6863	Chemical	Gene	START_ENTITY|nmod|concentrations concentrations|nmod|END_ENTITY	Effects of tramadol on synovial fluid concentrations of substance_P and interleukin-6 in patients with knee_osteoarthritis : comparison with paracetamol .
24933606	0	trametinib	12,22	BRAF	42,46	trametinib	BRAF	MESH:C560077	673	Chemical	Gene	Activity|nmod|START_ENTITY END_ENTITY|nsubj|Activity	Activity of trametinib in K601E and L597Q BRAF mutation-positive metastatic_melanoma .
25779165	0	trametinib	89,99	BRAF	38,42	trametinib	BRAF	MESH:C560077	673	Chemical	Gene	Combining|dep|START_ENTITY Combining|dobj|inhibitor inhibitor|amod|END_ENTITY	Combining targeted and immunotherapy : BRAF inhibitor dabrafenib -LRB- D -RRB- the MEK inhibitor trametinib -LRB- T -RRB- in combination with ipilimumab -LRB- Ipi -RRB- for V600E/K mutation-positive unresectable or metastatic_melanoma -LRB- MM -RRB- .
23438367	0	trametinib	20,30	MEK	6,9	trametinib	MEK	MESH:C560077	5609	Chemical	Gene	gene|compound|START_ENTITY inhibitor|dobj|gene inhibitor|nsubj|END_ENTITY	Novel MEK inhibitor trametinib and other retinoblastoma gene -LRB- RB -RRB- - reactivating agents enhance efficacy of 5-fluorouracil on human colon_cancer cells .
23583440	0	trametinib	20,30	MEK	81,84	trametinib	MEK	MESH:C560077	5609	Chemical	Gene	study|nmod|START_ENTITY inhibitor|nsubj|study inhibitor|nsubj|Mitogen-activated_protein_kinase_kinase Mitogen-activated_protein_kinase_kinase|appos|END_ENTITY	A phase 1b study of trametinib , an oral Mitogen-activated_protein_kinase_kinase -LRB- MEK -RRB- inhibitor , in combination with gemcitabine in advanced solid tumours .
23893461	0	trametinib	73,83	MEK	102,105	trametinib	MEK	MESH:C560077	5609	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Evaluation of the effects of food on the single-dose pharmacokinetics of trametinib , a first-in-class MEK inhibitor , in patients with cancer .
24606567	0	trametinib	53,63	MEK	67,70	trametinib	MEK	MESH:C560077	5609	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Concomitant oral and intravenous pharmacokinetics of trametinib , a MEK inhibitor , in subjects with solid tumours .
24915778	0	trametinib	56,66	MEK	76,79	trametinib	MEK	MESH:C560077	5609	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	A randomised , double-blind , placebo-controlled trial of trametinib , an oral MEK inhibitor , in combination with gemcitabine for patients with untreated metastatic adenocarcinoma_of_the_pancreas .
26723875	0	trametinib	127,137	MEK	112,115	trametinib	MEK	MESH:C560077	5609	Chemical	Gene	sensitizes|xcomp|START_ENTITY sensitizes|nmod|resistance resistance|nmod|inhibitor inhibitor|compound|END_ENTITY	The HSP90 inhibitor , NVP-AUY922 , sensitizes KRAS-mutant non-small_cell_lung_cancer with intrinsic resistance to MEK inhibitor , trametinib .
26940938	0	trametinib	53,63	MEK	67,70	trametinib	MEK	MESH:C560077	5609	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Population pharmacokinetics and exposure-response of trametinib , a MEK inhibitor , in patients with BRAF V600 mutation-positive melanoma .
25243813	0	trametinib	60,70	NF1	30,33	trametinib	NF1	MESH:C560077	4763	Chemical	Gene	status|nmod|START_ENTITY status|compound|END_ENTITY	BRAF/NRAS wild-type melanoma , NF1 status and sensitivity to trametinib .
10406358	0	trandolapril	24,36	ACE	10,13	trandolapril	ACE	MESH:C052035	1636	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|Effect Effect|nmod|END_ENTITY	Effect of ACE inhibitor trandolapril on life expectancy of patients with reduced left-ventricular function after acute myocardial_infarction .
8788966	0	trandolapril	33,45	ACE	68,71	trandolapril	ACE	MESH:C052035	24310(Tax:10116)	Chemical	Gene	treatment|nmod|START_ENTITY Effect|nmod|treatment END_ENTITY|nsubj|Effect	Effect of chronic treatment with trandolapril or enalapril on brain ACE activity in spontaneously hypertensive rats .
9872248	0	trandolapril	56,68	ACE	41,44	trandolapril	ACE	MESH:C052035	1636	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Effect of angiotensin-converting-enzyme -LRB- ACE -RRB- inhibitor trandolapril on human diabetic_neuropathy : randomised double-blind controlled trial .
2459935	0	trandolapril	48,60	ace	33,36	trandolapril	ace	MESH:C052035	24310(Tax:10116)	Chemical	Gene	inhibitors|xcomp|START_ENTITY inhibitors|nsubj|Comparison Comparison|nmod|effects effects|nmod|END_ENTITY	Comparison of the effects of the ace inhibitors trandolapril and enalapril on phlogogen induced foot pad oedema in the rat .
7477219	0	trandolapril	64,76	angiotensin-converting-enzyme	24,53	trandolapril	angiotensin-converting-enzyme	MESH:C052035	1636	Chemical	Gene	START_ENTITY|nsubj|trial trial|nmod|inhibitor inhibitor|amod|END_ENTITY	A clinical trial of the angiotensin-converting-enzyme inhibitor trandolapril in patients with left_ventricular_dysfunction after myocardial_infarction .
9872248	0	trandolapril	56,68	angiotensin-converting-enzyme	10,39	trandolapril	angiotensin-converting-enzyme	MESH:C052035	1636	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Effect of angiotensin-converting-enzyme -LRB- ACE -RRB- inhibitor trandolapril on human diabetic_neuropathy : randomised double-blind controlled trial .
10399995	0	trandolapril	54,66	angiotensin-converting_enzyme	14,43	trandolapril	angiotensin-converting enzyme	MESH:C052035	1636	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|inhibitor inhibitor|amod|END_ENTITY	Effect of the angiotensin-converting_enzyme inhibitor trandolapril on mortality and morbidity in diabetic patients with left_ventricular_dysfunction after acute myocardial_infarction .
15055251	0	trandolapril	116,128	angiotensin-converting_enzyme	76,105	trandolapril	angiotensin-converting enzyme	MESH:C052035	1636	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|bedtime bedtime|nmod|administration administration|nmod|inhibitor inhibitor|amod|END_ENTITY	Effects of bedtime vs. morning administration of the long-acting lipophilic angiotensin-converting_enzyme inhibitor trandolapril on morning blood pressure in hypertensive patients .
15752941	0	trandolapril	82,94	angiotensin-converting_enzyme	20,49	trandolapril	angiotensin-converting enzyme	MESH:C052035	24310(Tax:10116)	Chemical	Gene	administration|nmod|START_ENTITY END_ENTITY|nmod|administration	Inhibition of brain angiotensin-converting_enzyme by peripheral administration of trandolapril versus lisinopril in Wistar_rats .
8480624	0	trandolapril	25,37	angiotensin-converting_enzyme	45,74	trandolapril	angiotensin-converting enzyme	MESH:C052035	1636	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Pharmacologic profile of trandolapril , a new angiotensin-converting_enzyme inhibitor .
7474361	0	trandolapril	11,23	angiotensin_I_converting_enzyme	35,66	trandolapril	angiotensin I converting enzyme	MESH:C052035	24310(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|compound|END_ENTITY	Effects of trandolapril on cardiac angiotensin_I_converting_enzyme activity in rats with chronic_heart_failure following myocardial_infarction .
1480537	0	trandolapril	129,141	angiotensin_converting_enzyme	88,117	trandolapril	angiotensin converting enzyme	MESH:C052035	1636	Chemical	Gene	START_ENTITY|nsubj|Absence Absence|nmod|potentiation potentiation|acl|intradermal intradermal|nmod|inhibitor inhibitor|compound|END_ENTITY	Absence of potentiation of the skin response to intradermal bradykinin by a long-acting angiotensin_converting_enzyme inhibitor , trandolapril , at conventional antihypertensive dosage in human volunteers : a double-blind , randomized , cross-over , placebo-controlled trial .
2537217	0	trandolapril	45,57	angiotensin_converting_enzyme	77,106	trandolapril	angiotensin converting enzyme	MESH:C052035	1636	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Safety and tolerance of single oral doses of trandolapril -LRB- RU 44.570 -RRB- , a new angiotensin_converting_enzyme inhibitor .
7925522	0	trandolapril	76,88	angiotensin_converting_enzyme	35,64	trandolapril	angiotensin converting enzyme	MESH:C052035	613133(Tax:9823)	Chemical	Gene	decreases_ventricular_fibrillation|amod|START_ENTITY pretreatment|appos|decreases_ventricular_fibrillation pretreatment|nmod|inhibitor inhibitor|amod|END_ENTITY	Chronic oral pretreatment with the angiotensin_converting_enzyme inhibitor , trandolapril decreases_ventricular_fibrillation in acute ischaemia and reperfusion .
15475654	0	trandolapril	39,51	endoglin	55,63	trandolapril	endoglin	MESH:C052035	497010(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of the long-term treatment with trandolapril on endoglin expression in rats with experimental renal_fibrosis induced by renal mass reduction .
9589381	0	trandolapril	16,28	erythropoietin	38,52	trandolapril	erythropoietin	MESH:C052035	2056	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Acute effect of trandolapril on serum erythropoietin in uremic and hypertensive patients .
23052111	0	tranexamic_acid	52,67	factor_Xa	81,90	tranexamic acid	factor Xa	MESH:D014148	2159	Chemical	Gene	inhibitor|compound|START_ENTITY inhibitor|compound|END_ENTITY	Less blood_loss under concomitant administration of tranexamic_acid and indirect factor_Xa inhibitor following total knee arthroplasty : a prospective randomized controlled trial .
12846058	0	tranexamic_acid	44,59	plasmin	25,32	tranexamic acid	plasmin	MESH:D014148	5340	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|antagonist antagonist|compound|END_ENTITY	No therapeutic effect of plasmin antagonist tranexamic_acid in rheumatoid_arthritis .
14739127	0	tranexamic_acid	34,49	plasmin	14,21	tranexamic acid	plasmin	MESH:D014148	5340	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Inhibition of plasmin activity by tranexamic_acid does not influence inflammatory pathways during human endotoxemia .
20185649	0	tranexamic_acid	71,86	plasmin	51,58	tranexamic acid	plasmin	MESH:D014148	5340	Chemical	Gene	Temporally|nmod|START_ENTITY Temporally|nmod|activity activity|compound|END_ENTITY	Temporally and regionally disparate differences in plasmin activity by tranexamic_acid .
2551068	0	tranexamic_acid	14,29	plasmin	118,125	tranexamic acid	plasmin	MESH:D014148	5340	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition by tranexamic_acid of the conversion of single-chain tissue plasminogen activator to its two chain form by plasmin : the presence on tissue plasminogen activator of a site to bind with lysine binding sites of plasmin .
2551068	0	tranexamic_acid	14,29	plasmin	219,226	tranexamic acid	plasmin	MESH:D014148	5340	Chemical	Gene	Inhibition|nmod|START_ENTITY presence|dep|Inhibition presence|nmod|activator activator|nmod|site site|nmod|bind bind|nmod|sites sites|nmod|END_ENTITY	Inhibition by tranexamic_acid of the conversion of single-chain tissue plasminogen activator to its two chain form by plasmin : the presence on tissue plasminogen activator of a site to bind with lysine binding sites of plasmin .
6447383	0	tranexamic_acid	28,43	plasmin	15,22	tranexamic acid	plasmin	MESH:D014148	5340	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of plasmin with tranexamic_acid and alpha_2_plasmin_inhibitor in the plasma and clot .
18723040	0	trans,trans-muconaldehyde	23,48	connexin43	114,124	trans,trans-muconaldehyde	connexin43	null	2697	Chemical	Gene	blocks|nsubj|START_ENTITY blocks|nmod|END_ENTITY	The benzene metabolite trans,trans-muconaldehyde blocks gap junction intercellular communication by cross-linking connexin43 .
1888328	0	trans-3-phenylglycidols	45,68	cytosolic_epoxide_hydrolase	14,41	trans-3-phenylglycidols	cytosolic epoxide hydrolase	null	13850(Tax:10090)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of cytosolic_epoxide_hydrolase by trans-3-phenylglycidols .
20709139	0	trans-Resveratrol	0,17	Txnip	32,37	trans-Resveratrol	Txnip	MESH:C059514	10628	Chemical	Gene	downregulates|amod|START_ENTITY END_ENTITY|nsubj|downregulates	trans-Resveratrol downregulates Txnip overexpression occurring during liver_ischemia-reperfusion .
2825725	0	trans-stilbene_oxide	65,85	cytochrome_P-450	26,42	trans-stilbene oxide	cytochrome P-450	MESH:C025906	25251(Tax:10116)	Chemical	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	Differential induction of cytochrome_P-450 by the enantiomers of trans-stilbene_oxide .
11372684	0	transition_metals	69,86	Histidine-proline-rich_glycoprotein	0,35	transition metals	Histidine-proline-rich glycoprotein	CHEBI:27081	3273	Chemical	Gene	mediated|nmod|START_ENTITY mediated|nsubj|END_ENTITY	Histidine-proline-rich_glycoprotein binding to platelets mediated by transition_metals .
18614155	0	transmembrane	20,33	melanocortin-3_receptor	52,75	transmembrane	melanocortin-3 receptor	null	4159	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	Functions of acidic transmembrane residues in human melanocortin-3_receptor binding and activation .
16870733	0	transmembrane_AMPA	20,38	Stargazin	0,9	transmembrane AMPA	Stargazin	null	10369	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Stargazin and other transmembrane_AMPA receptor regulating proteins interact with synaptic scaffolding protein MAGI-2 in brain .
20415477	0	tranylcypromine	54,69	LSD1	120,124	tranylcypromine	LSD1	MESH:D014191	23028	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|inhibitors inhibitors|nmod|END_ENTITY	Biochemical , structural , and biological evaluation of tranylcypromine derivatives as inhibitors of histone demethylases LSD1 and LSD2 .
21382717	0	tranylcypromine	30,45	LSD1	79,83	tranylcypromine	LSD1	MESH:D014191	23028	Chemical	Gene	analogues|amod|START_ENTITY synthesis|nmod|analogues synthesis|appos|END_ENTITY	Enantioselective synthesis of tranylcypromine analogues as lysine_demethylase -LRB- LSD1 -RRB- inhibitors .
26881714	0	tranylcypromine	45,60	LSD1	13,17	tranylcypromine	LSD1	MESH:D014191	23028	Chemical	Gene	Application|nmod|START_ENTITY inhibitors|dep|Application inhibitors|compound|END_ENTITY	Irreversible LSD1 inhibitors : Application of tranylcypromine and its derivatives in cancer treatment .
15614572	0	trazodone	30,39	5-HT_2A	43,50	trazodone	5-HT 2A	MESH:D014196	29595(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Effects of the antidepressant trazodone , a 5-HT_2A / 2C receptor antagonist , on dopamine-dependent behaviors in rats .
6685809	0	trazodone	29,38	prolactin	63,72	trazodone	prolactin	MESH:D014196	24683(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY administration|nmod|END_ENTITY	Effects of acute and chronic trazodone administration on serum prolactin levels in adult female rats .
7465018	0	trazodone	31,40	prolactin	45,54	trazodone	prolactin	MESH:D014196	5617	Chemical	Gene	drug|appos|START_ENTITY Effect|nmod|drug Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of a psychoactive drug , trazodone , on prolactin secretion in man .
17031512	0	trehalose	39,48	ABI4	0,4	trehalose	ABI4	MESH:D014199	818614(Tax:3702)	Chemical	Gene	effects|nmod|START_ENTITY mediates|dobj|effects mediates|nsubj|END_ENTITY	ABI4 mediates the effects of exogenous trehalose on Arabidopsis growth and starch breakdown .
11402215	0	trehalose	32,41	ApL1	109,113	trehalose	ApL1	MESH:D014199	832042(Tax:3702)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nsubj|END_ENTITY	Induction of ApL3 expression by trehalose complements the starch-deficient Arabidopsis mutant adg2-1 lacking ApL1 , the large subunit of ADP-glucose pyrophosphorylase .
11402215	0	trehalose	32,41	ApL3	13,17	trehalose	ApL3	MESH:D014199	830076(Tax:3702)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|expression expression|amod|END_ENTITY	Induction of ApL3 expression by trehalose complements the starch-deficient Arabidopsis mutant adg2-1 lacking ApL1 , the large subunit of ADP-glucose pyrophosphorylase .
8850521	0	trehalose	30,39	TSL1	22,26	trehalose	TSL1	MESH:D014199	854872(Tax:4932)	Chemical	Gene	activity|amod|START_ENTITY role|nmod|activity role|nmod|END_ENTITY	A regulatory role for TSL1 on trehalose synthase activity .
19620241	0	trehalose	4,13	hexokinase_2	80,92	trehalose	hexokinase 2	MESH:D014199	852639(Tax:4932)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	The trehalose pathway regulates mitochondrial respiratory chain content through hexokinase_2 and cAMP in Saccharomyces_cerevisiae .
22894179	0	trehalose	18,27	lysozyme	42,50	trehalose	lysozyme	MESH:D014199	4069	Chemical	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	How strongly does trehalose interact with lysozyme in the solid state ?
8070577	0	trehalose	56,65	tps1	31,35	trehalose	tps1	MESH:D014199	852423(Tax:4932)	Chemical	Gene	synthesis|amod|START_ENTITY END_ENTITY|nmod|synthesis	Heat-shock response in a yeast tps1 mutant deficient in trehalose synthesis .
16894739	0	trehalose	22,31	trehalase	48,57	trehalose	trehalase	MESH:D014199	11181	Chemical	Gene	concentration|nmod|START_ENTITY concentration|nmod|END_ENTITY	-LSB- The concentration of trehalose and acitvity of trehalase from Galleria mellonella larvae infected by Steinernema affinis , Bovien 1937 -LRB- Nematoda : Rhabditida : Steinernematidae -RRB- -RSB- .
19521507	0	trehalose_dimycolate	86,106	MARCO	0,5	trehalose dimycolate	MARCO	null	17167(Tax:10090)	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	MARCO , TLR2 , and CD14 are required for macrophage cytokine responses to mycobacterial trehalose_dimycolate and Mycobacterium_tuberculosis .
10586120	0	trehalose_dimycolate	79,99	Tumor_necrosis_factor	0,21	trehalose dimycolate	Tumor necrosis factor	null	21926(Tax:10090)	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Tumor_necrosis_factor is required for the priming of peritoneal macrophages by trehalose_dimycolate .
21037064	0	trehazolin	45,55	trehalase	25,34	trehazolin	trehalase	MESH:C071816	11181	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Long-term effects of the trehalase inhibitor trehazolin on trehalase activity in locust flight muscle .
21037064	0	trehazolin	45,55	trehalase	59,68	trehazolin	trehalase	MESH:C071816	11181	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Long-term effects of the trehalase inhibitor trehazolin on trehalase activity in locust flight muscle .
26523434	0	trelagliptin	41,53	DPP-4	24,29	trelagliptin	DPP-4	MESH:C000595449	1803	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	First novel once-weekly DPP-4 inhibitor , trelagliptin , for the treatment of type_2_diabetes_mellitus .
22503145	0	trenbolone_acetate	41,59	oxytocin	137,145	trenbolone acetate	oxytocin	MESH:D014204	443390(Tax:9940)	Chemical	Gene	treatment|nmod|START_ENTITY effect|nmod|treatment effect|nmod|END_ENTITY	The effect of combination treatment with trenbolone_acetate and estradiol-17b on skeletal muscle expression and plasma concentrations of oxytocin in sheep .
9578689	0	trephine	80,88	GTS	76,79	trephine	GTS	null	2973	Chemical	Gene	system|compound|START_ENTITY system|compound|END_ENTITY	-LSB- Rise in intraocular tension in microkeratome sections -LRB- LASIK -RRB- and with the GTS trephine system for keratoplasty -RSB- .
25542069	0	treprostinil	61,73	DP1	111,114	treprostinil	DP1	MESH:C427248	64679(Tax:10116)	Chemical	Gene	START_ENTITY|appos|activity activity|compound|END_ENTITY	Assessing the agonist profiles of the prostacyclin analogues treprostinil and naxaprostene , particularly their DP1 activity .
11583025	0	tresperimus	10,21	CD34	51,55	tresperimus	CD34	MESH:C092303	947	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of tresperimus on in vitro human cord blood CD34 + cell differentiation .
12803107	0	tresperimus	10,21	CD34	46,50	tresperimus	CD34	MESH:C092303	947	Chemical	Gene	Effect|nmod|START_ENTITY expansion|dep|Effect expansion|nmod|CD38 CD38|compound|END_ENTITY	Effect of tresperimus on ex vivo expansion of CD34 + CD38 -LRB- - -RRB- - enriched cord blood cells .
12019205	0	tresperimus	23,34	semicarbazide-sensitive_amine_oxidase	53,90	tresperimus	semicarbazide-sensitive amine oxidase	MESH:C092303	314	Chemical	Gene	metabolism|nmod|START_ENTITY END_ENTITY|nsubj|metabolism	In vitro metabolism of tresperimus by human vascular semicarbazide-sensitive_amine_oxidase .
12685504	0	tresperimus	14,25	semicarbazide-sensitive_amine_oxidase	39,76	tresperimus	semicarbazide-sensitive amine oxidase	MESH:C092303	29473(Tax:10116)	Chemical	Gene	Metabolism|nmod|START_ENTITY Metabolism|nmod|END_ENTITY	Metabolism of tresperimus by rat aorta semicarbazide-sensitive_amine_oxidase -LRB- SSAO -RRB- .
21525632	0	trh	55,58	thyrotropin_releasing_hormone	24,53	trh	thyrotropin releasing hormone	CHEBI:35940	25569(Tax:10116)	Chemical	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The metabolic effect of thyrotropin_releasing_hormone -LRB- trh -RRB- and norepinephrine -LRB- ne -RRB- in warm-acclimated obese rats - biomed 2011 .
5497467	0	tri-hydroxymethyl-aminomethane	10,40	insulin	51,58	tri-hydroxymethyl-aminomethane	insulin	MESH:D014325	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of tri-hydroxymethyl-aminomethane -LRB- Tris -RRB- on insulin secretion in vitro .
1431676	0	tri-iodothyronine	11,28	IGF-I	63,68	tri-iodothyronine	IGF-I	MESH:D014284	24482(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of tri-iodothyronine and insulin-like_growth_factor-I -LRB- IGF-I -RRB- on alkaline phosphatase activity , -LSB- 3H -RSB- thymidine incorporation and IGF-I_receptor mRNA in cultured rat epiphyseal chondrocytes .
8320266	0	tri-iodothyronine	26,43	Neurotrophin-3	0,14	tri-iodothyronine	Neurotrophin-3	MESH:D014284	81737(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Neurotrophin-3 induced by tri-iodothyronine in cerebellar granule cells promotes Purkinje cell differentiation .
7507935	0	tri-iodothyronine	23,40	alpha-fetoprotein	62,79	tri-iodothyronine	alpha-fetoprotein	MESH:D014284	11576(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	The regulatory role of tri-iodothyronine on the production of alpha-fetoprotein and albumin by mouse fetal liver cells .
9601064	0	tri-iodothyronine	10,27	leptin	31,37	tri-iodothyronine	leptin	MESH:D014284	25608(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|release release|compound|END_ENTITY	Effect of tri-iodothyronine on leptin release and leptin mRNA accumulation in rat adipose tissue .
3754852	0	tri-n-butyl_phosphate	59,80	transferrin	28,39	tri-n-butyl phosphate	transferrin	MESH:C009524	7018	Chemical	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	The binding of plutonium to transferrin in the presence of tri-n-butyl_phosphate or nitrate and its release by diethylenetriaminepenta-acetate and the tetrameric catechoylamide ligand LICAMC -LRB- C -RRB- .
23140885	0	tri-substituted_thiazoles	50,75	RAGE	79,83	tri-substituted thiazoles	RAGE	null	101669765	Chemical	Gene	START_ENTITY|nmod|antagonists antagonists|amod|END_ENTITY	Synthesis and structure-activity relationships of tri-substituted_thiazoles as RAGE antagonists for the treatment of Alzheimer 's _ disease .
21316234	0	tri-substituted_thiophene	65,90	JNK	97,100	tri-substituted thiophene	JNK	null	26419(Tax:10090)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	Design and synthesis of a novel , orally active , brain penetrant , tri-substituted_thiophene based JNK inhibitor .
22359057	0	triabin	34,41	thrombin	51,59	triabin	thrombin	MESH:C097048	2147	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Optimization of the production of triabin , a novel thrombin inhibitor , in High Five insect cells infected with a recombinant baculovirus .
9241757	0	triabin	52,59	thrombin	99,107	triabin	thrombin	MESH:C097048	2147	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Inhibition of thrombin-mediated cellular effects by triabin , a highly potent anion-binding exosite thrombin inhibitor .
9342325	0	triabin	39,46	thrombin	17,25	triabin	thrombin	MESH:C097048	280685(Tax:9913)	Chemical	Gene	complex|nmod|START_ENTITY complex|compound|END_ENTITY	Structure of the thrombin complex with triabin , a lipocalin-like exosite-binding inhibitor derived from a triatomine bug .
8997458	0	triacetyloleandomycin	63,84	CYP3A	110,115	triacetyloleandomycin	CYP3A	MESH:D014217	170509(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Protection of ethanol-mediated acetaminophen hepatotoxicity by triacetyloleandomycin , a specific inhibitor of CYP3A .
8203907	0	triacetyloleandomycin	14,35	P450	150,154	triacetyloleandomycin	P450	MESH:D014217	1555	Chemical	Gene	Evaluation|nmod|START_ENTITY Evaluation|nmod|END_ENTITY	Evaluation of triacetyloleandomycin , alpha-naphthoflavone and diethyldithiocarbamate as selective chemical probes for inhibition of human cytochromes P450 .
3871804	0	triacetyloleandomycin	15,36	glucocorticoid_receptor	71,94	triacetyloleandomycin	glucocorticoid receptor	MESH:D014217	2908	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of triacetyloleandomycin and oleandomycin_phosphate on the glucocorticoid_receptor in cultured skin fibroblasts .
12072432	0	triacylglycerol	81,96	ApoB	117,121	triacylglycerol	ApoB	MESH:D014280	238055(Tax:10090)	Chemical	Gene	START_ENTITY|acl|associated associated|nmod|END_ENTITY	Microsomal_triacylglycerol_transfer_protein is required for lumenal accretion of triacylglycerol not associated with ApoB , as well as for ApoB lipidation .
18156661	0	triacylglycerol	55,70	C-reactive-protein	81,99	triacylglycerol	C-reactive-protein	MESH:D014280	1401	Chemical	Gene	START_ENTITY|dobj|concentrations concentrations|amod|END_ENTITY	Multiple bouts of resistance exercise and postprandial triacylglycerol and serum C-reactive-protein concentrations .
20715096	0	triacylglycerol	116,131	CYP7A1	171,177	triacylglycerol	CYP7A1	MESH:D014280	1581	Chemical	Gene	protein|compound|START_ENTITY protein|nmod|END_ENTITY	Dietary calcium decreases plasma cholesterol by down-regulation of intestinal Niemann-Pick_C1_like_1 and microsomal triacylglycerol transport protein and up-regulation of CYP7A1 and ABCG_5 / 8 in hamsters .
2403299	0	triacylglycerol	31,46	Lipoprotein_lipase	0,18	triacylglycerol	Lipoprotein lipase	MESH:D014280	403626(Tax:9615)	Chemical	Gene	activities|amod|START_ENTITY activities|amod|END_ENTITY	Lipoprotein_lipase and hepatic triacylglycerol lipase activities in peripheral and skeletal muscle lymph .
20715096	0	triacylglycerol	116,131	Niemann-Pick_C1_like_1	78,100	triacylglycerol	Niemann-Pick C1 like 1	MESH:D014280	29881	Chemical	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	Dietary calcium decreases plasma cholesterol by down-regulation of intestinal Niemann-Pick_C1_like_1 and microsomal triacylglycerol transport protein and up-regulation of CYP7A1 and ABCG_5 / 8 in hamsters .
26979516	0	triacylglycerol	56,71	PHM8	40,44	triacylglycerol	PHM8	MESH:D014280	856759(Tax:4932)	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|compound|END_ENTITY	The transcription factor GCN4 regulates PHM8 and alters triacylglycerol metabolism in Saccharomyces_cerevisiae .
26573195	0	triacylglycerol	63,78	PNPLA3	86,92	triacylglycerol	PNPLA3	MESH:D014280	80339	Chemical	Gene	-RSB-|amod|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Role of SREBP-1c in risk of liver_disease associated with the triacylglycerol lipase PNPLA3 I148M variant -RSB- .
17182804	0	triacylglycerol	46,61	PPARalpha	103,112	triacylglycerol	PPARalpha	MESH:D014280	25747(Tax:10116)	Chemical	Gene	accumulation|compound|START_ENTITY accumulation|nmod|END_ENTITY	Dietary oxidized fat prevents ethanol-induced triacylglycerol accumulation and increases expression of PPARalpha target genes in rat liver .
17005995	0	triacylglycerol	66,81	SREBP-1c	101,109	triacylglycerol	SREBP-1c	MESH:D014280	6720	Chemical	Gene	START_ENTITY|nmod|suppression suppression|nmod|END_ENTITY	Trans geometric isomers of EPA decrease LXRalpha-induced cellular triacylglycerol via suppression of SREBP-1c and PGC-1beta .
23680128	0	triacylglycerol	75,90	SREBP-1c	110,118	triacylglycerol	SREBP-1c	MESH:D014280	6720	Chemical	Gene	START_ENTITY|nmod|suppression suppression|nmod|END_ENTITY	Oxidized_eicosapentaenoic_acids more potently reduce LXRa-induced cellular triacylglycerol via suppression of SREBP-1c , PGC-1b and GPA than its intact form .
17972059	0	triacylglycerol	37,52	TCF7L2	0,6	triacylglycerol	TCF7L2	MESH:D014280	6934	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	TCF7L2 is associated with high serum triacylglycerol and differentially expressed in adipose tissue in families with familial_combined_hyperlipidaemia .
3356950	0	triacylglycerol	39,54	apoB	82,86	triacylglycerol	apoB	MESH:D014280	54225(Tax:10116)	Chemical	Gene	synthesis|amod|START_ENTITY synthesis|compound|END_ENTITY	Developmental coordinate expression of triacylglycerol and small molecular weight apoB synthesis and secretion by rat hepatocytes .
9026354	0	triacylglycerol	21,36	insulin	10,17	triacylglycerol	insulin	MESH:D014280	396145(Tax:9031)	Chemical	Gene	synthesis|amod|START_ENTITY Effect|nmod|synthesis Effect|nmod|END_ENTITY	Effect of insulin on triacylglycerol synthesis and secretion by chicken hepatocytes in primary culture .
15035680	0	triacylglycerol	34,49	lactoferrin	7,18	triacylglycerol	lactoferrin	MESH:D014280	17002(Tax:10090)	Chemical	Gene	reduces|dobj|START_ENTITY reduces|nsubj|END_ENTITY	Bovine lactoferrin reduces plasma triacylglycerol and NEFA accompanied by decreased hepatic cholesterol and triacylglycerol contents in rodents .
2403299	0	triacylglycerol	31,46	lipase	47,53	triacylglycerol	lipase	MESH:D014280	404010(Tax:9615)	Chemical	Gene	activities|amod|START_ENTITY activities|compound|END_ENTITY	Lipoprotein_lipase and hepatic triacylglycerol lipase activities in peripheral and skeletal muscle lymph .
9396715	0	triacylglycerol	37,52	lipoprotein_lipase	67,85	triacylglycerol	lipoprotein lipase	MESH:D014280	16956(Tax:10090)	Chemical	Gene	hydrolysis|compound|START_ENTITY hydrolysis|nmod|END_ENTITY	Nascent very-low-density lipoprotein triacylglycerol hydrolysis by lipoprotein_lipase is inhibited by apolipoprotein_E in a dose-dependent manner .
16814984	0	triacylglycerol	150,165	paraoxonase-1	136,149	triacylglycerol	paraoxonase-1	MESH:D014280	18979(Tax:10090)	Chemical	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Postprandial serum triacylglycerols and oxidative stress in mice after consumption of fish oil , soy oil or olive oil : possible role for paraoxonase-1 triacylglycerol lipase-like activity .
24308640	0	triacylglycerols	52,68	PCSK9	12,17	triacylglycerols	PCSK9	MESH:D014280	255738	Chemical	Gene	determinant|nmod|START_ENTITY determinant|nsubj|END_ENTITY	Circulating PCSK9 is a strong determinant of plasma triacylglycerols and total cholesterol in homozygous carriers of apolipoprotein 2 .
6173039	0	triacylglycerols	68,84	lipoprotein_lipase	17,35	triacylglycerols	lipoprotein lipase	MESH:D014280	24539(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	Possible role of lipoprotein_lipase in the regulation of endogenous triacylglycerols in the rat heart .
8907238	0	triacylglycerols	124,140	sn-2	96,100	triacylglycerols	sn-2	MESH:D014280	92745	Chemical	Gene	analysis|nmod|START_ENTITY analysis|amod|END_ENTITY	Comparison of the grignard deacylation TLC and HPLC methods and high resolution 13C-NMR for the sn-2 positional analysis of triacylglycerols containing gamma-linolenic_acid .
3109439	0	trialkyl_phosphorothioates	63,89	cytochrome_P-450	36,52	trialkyl phosphorothioates	cytochrome P-450	null	25251(Tax:10116)	Chemical	Gene	system|nmod|START_ENTITY system|amod|END_ENTITY	Induction of the hepatic microsomal cytochrome_P-450 system by trialkyl_phosphorothioates in rats .
17167405	0	triamcinolone	11,24	VEGF	46,50	triamcinolone	VEGF	MESH:D014221	7422	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of triamcinolone on the expression of VEGF and PEDF in human retinal pigment epithelial and human umbilical vein endothelial cells .
15728566	0	triamcinolone	90,103	connective_tissue_growth_factor	47,78	triamcinolone	connective tissue growth factor	MESH:D014221	1490	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|END_ENTITY	Vascular_endothelial_growth_factor reduced and connective_tissue_growth_factor induced by triamcinolone in ARPE19 cells under oxidative stress .
1197440	0	triamcinolone	38,51	glucose-6-phosphate_dehydrogenase	55,88	triamcinolone	glucose-6-phosphate dehydrogenase	MESH:D014221	2539	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|amod|END_ENTITY	Effects of intralesional injection of triamcinolone on glucose-6-phosphate_dehydrogenase and alanine aminotransferase activity in keloids .
14659961	0	triamcinolone	13,26	vascular_endothelial_growth_factor	48,82	triamcinolone	vascular endothelial growth factor	MESH:D014221	83785(Tax:10116)	Chemical	Gene	alter|nsubj|START_ENTITY alter|dobj|expression expression|compound|END_ENTITY	Intravitreal triamcinolone does not alter basal vascular_endothelial_growth_factor mRNA expression in rat retina .
15596583	0	triamcinolone	189,202	vascular_endothelial_growth_factor	19,53	triamcinolone	vascular endothelial growth factor	MESH:D014221	7422	Chemical	Gene	levels|nmod|START_ENTITY levels|nmod|END_ENTITY	Vitreous levels of vascular_endothelial_growth_factor and stromal-derived_factor_1 in patients with diabetic_retinopathy and cystoid_macular_edema before and after intraocular injection of triamcinolone .
18268209	0	triamcinolone	17,30	vascular_endothelial_growth_factor	34,68	triamcinolone	vascular endothelial growth factor	MESH:D014221	7422	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Early effects of triamcinolone on vascular_endothelial_growth_factor and endostatin in human choroidal_neovascularization .
19278477	0	triamcinolone	91,104	vascular_endothelial_growth_factor	19,53	triamcinolone	vascular endothelial growth factor	MESH:D014221	7422	Chemical	Gene	Changes|nmod|START_ENTITY Changes|nmod|aqueous aqueous|amod|END_ENTITY	Changes of aqueous vascular_endothelial_growth_factor and interleukin-6 after intravitreal triamcinolone for branch retinal_vein_occlusion .
18174522	0	triamcinolone_acetonide	13,36	VEGF-A	120,126	triamcinolone acetonide	VEGF-A	MESH:D014222	83785(Tax:10116)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|regulation regulation|nmod|END_ENTITY	Intravitreal triamcinolone_acetonide inhibits breakdown of the blood-retinal barrier through differential regulation of VEGF-A and its receptors in early diabetic rat retinas .
23260769	0	triamcinolone_acetonide	45,68	salvianolic_acid_B	12,30	triamcinolone acetonide	salvianolic acid B	MESH:D014222	9467	Chemical	Gene	combined|nmod|START_ENTITY combined|nsubj|Efficacy Efficacy|nmod|END_ENTITY	Efficacy of salvianolic_acid_B combined with triamcinolone_acetonide in the treatment of oral_submucous_fibrosis .
6424929	0	triamcinolone_acetonide	10,33	tyrosinase	37,47	triamcinolone acetonide	tyrosinase	MESH:D014222	7299	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	Effect of triamcinolone_acetonide on tyrosinase activity in a human melanoma cell line .
19211093	0	triamcinolone_acetonide	10,33	vascular_endothelial_growth_factor	37,71	triamcinolone acetonide	vascular endothelial growth factor	MESH:D014222	397157(Tax:9823)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|compound|END_ENTITY	Effect of triamcinolone_acetonide on vascular_endothelial_growth_factor and occludin levels in branch_retinal_vein_occlusion .
20005710	0	triaryl_bis-sulfone	39,58	CB2	59,62	triaryl bis-sulfone	CB2	null	57302(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Non-aromatic A-ring replacement in the triaryl_bis-sulfone CB2 receptor inhibitors .
26546221	0	triarylpyrazoline	102,119	COX-2	145,150	triarylpyrazoline	COX-2	null	4513	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Synthesis , cyclooxygenase inhibition , anti-inflammatory evaluation and ulcerogenic liability of novel triarylpyrazoline derivatives as selective COX-2 inhibitors .
25115848	0	triazacyclononane_europium	29,55	Bright	0,6	triazacyclononane europium	Bright	null	1820	Chemical	Gene	complexes|compound|START_ENTITY complexes|amod|END_ENTITY	Bright , highly water-soluble triazacyclononane_europium complexes to detect ligand binding with time-resolved FRET microscopy .
17350837	0	triazine	51,59	Tie-2	93,98	triazine	Tie-2	CHEBI:38056	89804(Tax:10116)	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Synthesis , structural analysis , and SAR studies of triazine derivatives as potent , selective Tie-2 inhibitors .
7815093	2	triazines	147,156	dihydrofolate_reductase	120,143	triazines	dihydrofolate reductase	MESH:D014227	1719	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	The inhibition of dihydrofolate_reductase by triazines .
14980654	0	triazole	21,29	CB1	30,33	triazole	CB1	CHEBI:38597	1268	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|compound|END_ENTITY	Potent imidazole and triazole CB1 receptor antagonists related to SR141716 .
11319239	0	triazole	25,33	DWF4	51,55	triazole	DWF4	CHEBI:38597	824229(Tax:3702)	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Selective interaction of triazole derivatives with DWF4 , a cytochrome_P450_monooxygenase of the brassinosteroid biosynthetic pathway , correlates with brassinosteroid_deficiency in planta .
26344911	0	triazole	42,50	VEGFR2	51,57	triazole	VEGFR2	CHEBI:38597	3791	Chemical	Gene	modulators|amod|START_ENTITY modulators|compound|END_ENTITY	Ynamide Click chemistry in development of triazole VEGFR2 TK modulators .
20565450	0	triazoles	81,90	cytochrome_P450_3A5	20,39	triazoles	cytochrome P450 3A5	MESH:D014230	1577	Chemical	Gene	impact|nmod|START_ENTITY impact|nmod|END_ENTITY	Potential impact of cytochrome_P450_3A5 in human liver on drug interactions with triazoles .
12873480	0	triazolethiol	66,79	CXCR2	80,85	triazolethiol	CXCR2	null	3579	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|amod|END_ENTITY	Hit-to-lead studies : the discovery of potent , orally bioavailable triazolethiol CXCR2 receptor antagonists .
22659092	0	triazoloacridinone	75,93	C-1305	133,139	triazoloacridinone	C-1305	null	1035004(Tax:199310)	Chemical	Gene	agents|amod|START_ENTITY agents|amod|END_ENTITY	Role of human UDP-glucuronosyltransferases in the biotransformation of the triazoloacridinone and imidazoacridinone antitumor agents C-1305 and C-1311 : highly selective substrates for UGT1A10 .
2845442	0	triazolobenzodiazepines	99,122	TRH	87,90	triazolobenzodiazepines	TRH	CHEBI:35501	7200	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of the binding and the behavioral effects of thyrotropin-releasing_hormone -LRB- TRH -RRB- by the triazolobenzodiazepines .
18475629	0	triazolodiazepine	11,28	interleukin-6	50,63	triazolodiazepine	interleukin-6	MESH:C052518	16193(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|production production|nmod|cells cells|amod|END_ENTITY	Effects of triazolodiazepine on the production of interleukin-6 from murine spleen cells and rabbit synovial cells in vitro .
16759861	0	triazolopyridine_oxazole	36,60	p38	61,64	triazolopyridine oxazole	p38	null	1432	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Structure-activity relationships of triazolopyridine_oxazole p38 inhibitors : identification of candidates for clinical development .
24332493	0	triazolopyrimidine	58,76	CXCR2	77,82	triazolopyrimidine	CXCR2	CHEBI:27091	3579	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|compound|END_ENTITY	The discovery of potent , orally bioavailable pyrazolo and triazolopyrimidine CXCR2 receptor antagonists .
15566292	0	triazolotriazine	41,57	adenosine_A2A_receptor	113,135	triazolotriazine	adenosine A2A receptor	null	135	Chemical	Gene	derivatives|nmod|START_ENTITY derivatives|nmod|antagonists antagonists|amod|END_ENTITY	Novel bicyclic piperazine derivatives of triazolotriazine and triazolopyrimidines as highly potent and selective adenosine_A2A_receptor antagonists .
15341934	0	triazolotriazine	24,40	adenosine_A2a_receptor	67,89	triazolotriazine	adenosine A2a receptor	null	11540(Tax:10090)	Chemical	Gene	derivatives|nmod|START_ENTITY derivatives|nmod|antagonists antagonists|amod|END_ENTITY	Triamino derivatives of triazolotriazine and triazolopyrimidine as adenosine_A2a_receptor antagonists .
21783934	0	tributyltin	35,46	GADD153	13,20	tributyltin	GADD153	MESH:C011559	1649	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|expression expression|compound|END_ENTITY	Induction of GADD153 expression by tributyltin in SH-SY5Y human neuroblastoma cells .
21185327	0	tributyltin	18,29	c-fos	38,43	tributyltin	c-fos	MESH:C011559	14281(Tax:10090)	Chemical	Gene	exposure|nmod|START_ENTITY induces|nsubj|exposure induces|dobj|activation activation|amod|END_ENTITY	Acute exposure to tributyltin induces c-fos activation in the hypothalamic arcuate nucleus of adult male mice .
21781745	0	tributyltin	33,44	c-fos	13,18	tributyltin	c-fos	MESH:C011559	314322(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Induction of c-fos expression by tributyltin in PC12 cells : involvement of intracellular Ca -LRB- 2 + -RRB- .
16039681	0	tributyltin	53,64	cytochrome_P-450	32,48	tributyltin	cytochrome P-450	MESH:C011559	25251(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	Sex difference in the principal cytochrome_P-450 for tributyltin metabolism in rats .
16978758	0	tributyltin	23,34	cytochrome_P-450	61,77	tributyltin	cytochrome P-450	MESH:C011559	4051	Chemical	Gene	metabolism|nmod|START_ENTITY vitro|dobj|metabolism vitro|nmod|isoforms isoforms|amod|END_ENTITY	In vitro metabolism of tributyltin and triphenyltin by human cytochrome_P-450 isoforms .
1335619	0	tributyltin_chloride	14,34	atrial_natriuretic_peptide	60,86	tributyltin chloride	atrial natriuretic peptide	MESH:C011559	24602(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|acl|END_ENTITY	The effect of tributyltin_chloride on vascular responses to atrial_natriuretic_peptide .
21397693	0	tributyltin_chloride	27,47	peroxisome_proliferator_activated_receptor_gamma	57,105	tributyltin chloride	peroxisome proliferator activated receptor gamma	MESH:C011559	19016(Tax:10090)	Chemical	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	The environmental obesogen tributyltin_chloride acts via peroxisome_proliferator_activated_receptor_gamma to induce adipogenesis in murine 3T3-L1 preadipocytes .
23946240	0	tricalcium_phosphates	46,67	Runx2	84,89	tricalcium phosphates	Runx2	null	860	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effects of SiO2 , SrO , MgO , and ZnO dopants in tricalcium_phosphates on osteoblastic Runx2 expression .
17639143	0	tricarbonyl_bisimine	12,32	fac	8,11	tricarbonyl bisimine	fac	null	2176	Chemical	Gene	complexes|compound|START_ENTITY complexes|compound|END_ENTITY	Rhenium fac tricarbonyl_bisimine complexes : biologically useful fluorochromes for cell imaging applications .
17055053	0	trichlorfon	14,25	acetylcholinesterase	29,49	trichlorfon	acetylcholinesterase	MESH:D014236	100697913	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|amod|END_ENTITY	The effect of trichlorfon on acetylcholinesterase activity and histopathology of cultivated fish Oreochromis_niloticus .
1858902	0	trichlormethiazide	15,33	PTH	52,55	trichlormethiazide	PTH	MESH:D014237	100351309(Tax:9986)	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of trichlormethiazide or amiloride with PTH in stimulating Ca2 + absorption in rabbit CNT .
15363585	0	trichloroacetate	124,140	peroxisome_proliferator-activated_receptor_alpha	12,60	trichloroacetate	peroxisome proliferator-activated receptor alpha	CHEBI:27455	19013(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of the peroxisome_proliferator-activated_receptor_alpha -LRB- PPARalpha -RRB- in responses to trichloroethylene and metabolites , trichloroacetate and dichloroacetate in mouse liver .
16142583	0	trichloroacetic_acid	48,68	vimentin	90,98	trichloroacetic acid	vimentin	MESH:D014238	81818(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effects of trichloroethylene and its metabolite trichloroacetic_acid on the expression of vimentin in the rat H9c2 cell line .
27015938	0	trichosanthin	43,56	PC3	81,84	trichosanthin	PC3	null	57332	Chemical	Gene	activity|nmod|START_ENTITY activity|nmod|END_ENTITY	The anti-cancerous activity of recombinant trichosanthin on prostate_cancer cell PC3 .
17296257	0	trichostatin_A	52,66	COX-2	32,37	trichostatin A	COX-2	MESH:C012589	5743	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Suppression of IL-1beta-induced COX-2 expression by trichostatin_A -LRB- TSA -RRB- in human endometrial stromal cells .
15202563	0	trichostatin_A	60,74	Estrogen_receptor	0,17	trichostatin A	Estrogen receptor	MESH:C012589	2099	Chemical	Gene	effects|nmod|START_ENTITY enhances|dobj|effects enhances|nsubj|END_ENTITY	Estrogen_receptor enhances the antiproliferative effects of trichostatin_A and HC-toxin in human breast_cancer cells .
25006442	0	trichostatin_A	36,50	Histone_deacetylase	0,19	trichostatin A	Histone deacetylase	MESH:C012589	9734	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Histone_deacetylase inhibition with trichostatin_A does not reverse severe angioproliferative pulmonary_hypertension in rats -LRB- 2013 Grover Conference series -RRB- .
10601571	0	trichostatin_A	33,47	IGFBP-3	11,18	trichostatin A	IGFBP-3	MESH:C012589	3486	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Modulating IGFBP-3 expression by trichostatin_A : potential therapeutic role in the treatment of hepatocellular_carcinoma .
20188708	0	trichostatin_A	61,75	NT-3	47,51	trichostatin A	NT-3	MESH:C012589	18205(Tax:10090)	Chemical	Gene	genes|nmod|START_ENTITY genes|compound|END_ENTITY	Differential epigenetic regulation of BDNF and NT-3 genes by trichostatin_A and 5-aza-2 ' - deoxycytidine in Neuro-2a cells .
17724474	0	trichostatin_A	34,48	Oct	85,88	trichostatin A	Oct	MESH:C012589	5362	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	The histone deacetylase inhibitor trichostatin_A induces GADD45 gamma expression via Oct and NF-Y binding sites .
16149071	0	trichostatin_A	28,42	acetylcholinesterase	51,71	trichostatin A	acetylcholinesterase	MESH:C012589	43	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Histone acetylase inhibitor trichostatin_A induces acetylcholinesterase expression and protects against organophosphate exposure .
26497760	0	trichostatin_A	22,36	adrenocorticotropic_hormone	40,67	trichostatin A	adrenocorticotropic hormone	MESH:C012589	18976(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|production production|amod|END_ENTITY	Inhibitory effects of trichostatin_A on adrenocorticotropic_hormone production and proliferation of corticotroph_tumor AtT-20 cells .
10579829	0	trichostatin_A	19,33	histone_deacetylase	51,70	trichostatin A	histone deacetylase	MESH:C012589	541953(Tax:4577)	Chemical	Gene	analogues|nmod|START_ENTITY analogues|nmod|inhibitors inhibitors|nmod|END_ENTITY	Amide analogues of trichostatin_A as inhibitors of histone_deacetylase and inducers of terminal cell differentiation .
25387339	0	trichostatin_a	10,24	gelsolin	28,36	trichostatin a	gelsolin	MESH:C012589	227753(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Effect of trichostatin_a on gelsolin levels , proteolysis of amyloid_precursor_protein , and amyloid Beta-protein load in the brain of transgenic mouse model of Alzheimer 's _ disease .
22683667	0	tricin	32,38	CXCL11	56,62	tricin	CXCL11	MESH:C017769	6373	Chemical	Gene	effects|nmod|START_ENTITY dependent|nsubj|effects dependent|nmod|END_ENTITY	Anti-cytomegalovirus effects of tricin are dependent on CXCL11 .
23434549	0	tricin	34,40	tyrosinase	44,54	tricin	tyrosinase	MESH:C017769	7299	Chemical	Gene	mechanism|nmod|START_ENTITY mechanism|nmod|END_ENTITY	Molecular inhibitory mechanism of tricin on tyrosinase .
20857426	0	triciribine	41,52	Akt	27,30	triciribine	Akt	MESH:C023764	207	Chemical	Gene	START_ENTITY|nsubj|testing testing|nmod|inhibitor inhibitor|compound|END_ENTITY	Preclinical testing of the Akt inhibitor triciribine in T-cell_acute_lymphoblastic_leukemia .
26033700	0	triciribine	19,30	Akt	4,7	triciribine	Akt	MESH:C023764	11651(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	The Akt inhibitor , triciribine , ameliorates chronic hypoxia-induced vascular pruning and TGFb-induced pulmonary_fibrosis .
11034119	0	triclosan	10,19	interferon-gamma	23,39	triclosan	interferon-gamma	MESH:D014260	3458	Chemical	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Effect of triclosan on interferon-gamma production and major histocompatibility complex class II expression in human gingival fibroblasts .
9584910	0	triclosan	10,19	interleukin-1_beta	23,41	triclosan	interleukin-1 beta	MESH:D014260	3553	Chemical	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Effect of triclosan on interleukin-1_beta production in human gingival fibroblasts challenged with tumor_necrosis_factor_alpha .
25193434	0	triclosan	24,33	peroxisome_proliferator-activated_receptor_alpha	71,119	triclosan	peroxisome proliferator-activated receptor alpha	MESH:D014260	5465	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activation activation|nmod|END_ENTITY	Differential effects of triclosan on the activation of mouse and human peroxisome_proliferator-activated_receptor_alpha .
26827900	0	triclosan	10,19	thyroid_peroxidase	109,127	triclosan	thyroid peroxidase	MESH:D014260	54314(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of triclosan , triclocarban , 2,2 ' ,4,4 ' - tetrabromodiphenyl_ether , and bisphenol_A on the iodide uptake , thyroid_peroxidase activity , and expression of genes involved in thyroid_hormone synthesis .
23352481	0	tricyclic_benzimidazolone	63,88	translocator_protein	118,138	tricyclic benzimidazolone	translocator protein	null	706	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	Design , synthesis and structure-activity relationship of novel tricyclic_benzimidazolone derivatives as potent 18 kDa translocator_protein -LRB- TSPO -RRB- ligands .
23602398	0	tricyclic_lactams	62,79	MK2	90,93	tricyclic lactams	MK2	null	9261	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Conformation constraint of anilides enabling the discovery of tricyclic_lactams as potent MK2 non-ATP competitive inhibitors .
26378168	0	tricyclic_polyketide	8,28	NTCP	124,128	tricyclic polyketide	NTCP	null	6554	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	A novel tricyclic_polyketide , vanitaracin_A , specifically inhibits the entry of hepatitis_B and D viruses through targeting NTCP .
26890113	2	tricyclic_pyrazole_carboxamides	79,110	CB2	124,127	tricyclic pyrazole carboxamides	CB2	null	1269	Chemical	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	Synthesis , biological evaluation and modelling of tricyclic_pyrazole_carboxamides as potential CB2 receptor ligands with antagonist/inverse agonist properties .
22162181	0	tridegin	45,53	factor_XIIIa	102,114	tridegin	factor XIIIa	MESH:C106835	2162	Chemical	Gene	characterization|nmod|START_ENTITY characterization|dep|inhibitors inhibitors|nmod|END_ENTITY	Synthesis and functional characterization of tridegin and its analogues : inhibitors and substrates of factor_XIIIa .
22486746	0	triethylene_glycol_dimethacrylate	10,43	cyclooxygenase-2	65,81	triethylene glycol dimethacrylate	cyclooxygenase-2	MESH:C020946	5743	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of triethylene_glycol_dimethacrylate on the cytotoxicity , cyclooxygenase-2 expression and prostanoids production in human dental pulp cells .
24993295	0	trifluoperazine	36,51	CaMKII	67,73	trifluoperazine	CaMKII	MESH:D014268	818	Chemical	Gene	independent|amod|START_ENTITY independent|nmod|END_ENTITY	Block of Kv4 .3 potassium channel by trifluoperazine independent of CaMKII .
11350043	0	trifluoperazine	45,60	DNA-dependent_protein_kinase	0,28	trifluoperazine	DNA-dependent protein kinase	MESH:D014268	5591	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|END_ENTITY	DNA-dependent_protein_kinase is inhibited by trifluoperazine .
2997891	0	trifluoperazine	11,26	antidiuretic_hormone	74,94	trifluoperazine	antidiuretic hormone	MESH:D014268	551	Chemical	Gene	Effects|nmod|START_ENTITY Effects|acl|END_ENTITY	Effects of trifluoperazine and verapamil on the hydro-osmotic response to antidiuretic_hormone in the urinary bladder of the toad .
10727421	0	trifluoperazine	73,88	calmodulin	11,21	trifluoperazine	calmodulin	MESH:D014268	808	Chemical	Gene	molecules|compound|START_ENTITY structure|nmod|molecules structure|nsubj|forms forms|compound|END_ENTITY	Ca2 + - bound calmodulin forms a compact globular structure on binding four trifluoperazine molecules in solution .
2438442	0	trifluoperazine	22,37	calmodulin	58,68	trifluoperazine	calmodulin	MESH:D014268	474584(Tax:9615)	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|inhibitor inhibitor|compound|END_ENTITY	Inhibitory effects of trifluoperazine and chlorpromazine , calmodulin inhibitor , on autoregulation of renal blood flow .
3600606	0	trifluoperazine	38,53	calmodulin	85,95	trifluoperazine	calmodulin	MESH:D014268	808	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|site site|nmod|END_ENTITY	Theoretical studies of the binding of trifluoperazine derivatives to site -LRB- 82-93 -RRB- of calmodulin : effect of lengthenings of the methylene linker chain on the binding affinity .
6331894	0	trifluoperazine	11,26	calmodulin	30,40	trifluoperazine	calmodulin	MESH:D014268	100352392(Tax:9986)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|compound|END_ENTITY	Effects of trifluoperazine , a calmodulin antagonist , on rabbit T - and B-cell responses to mitogens and antigen .
2039497	4	trifluoperazine	713,728	protein_kinase	682,696	trifluoperazine	protein kinase	MESH:D014268	1022	Chemical	Gene	inhibitors|nmod|START_ENTITY inhibitors|amod|END_ENTITY	The phosphorylation was inhibited by such phosphatidylserine - and/or Ca2 + competitive protein_kinase C inhibitors as trifluoperazine , palmitoylcarnitine and gossypol .
6336784	0	trifluoperazine	11,26	renin	30,35	trifluoperazine	renin	MESH:D014268	24715(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Effects of trifluoperazine on renin secretion of rat kidney slices .
6358462	0	trifluoperazine	103,118	renin	31,36	trifluoperazine	renin	MESH:D014268	24715(Tax:10116)	Chemical	Gene	studies|nmod|START_ENTITY role|dep|studies role|nmod|calmodulin calmodulin|nmod|secretion secretion|compound|END_ENTITY	Possible role of calmodulin in renin secretion from isolated rat kidneys and renal cells : studies with trifluoperazine .
6849870	0	trifluoperazine	18,33	troponin_C	50,60	trifluoperazine	troponin C	MESH:D014268	100301551(Tax:9986)	Chemical	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Localization of a trifluoperazine binding site on troponin_C .
17630790	0	trifluoroethanol	16,32	angiotensin_II	44,58	trifluoroethanol	angiotensin II	MESH:D014270	183	Chemical	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of trifluoroethanol with -LSB- val5 -RSB- angiotensin_II .
19701810	0	trifluoroethanol	14,30	tyrosinase	34,44	trifluoroethanol	tyrosinase	MESH:D014270	7299	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	The effect of trifluoroethanol on tyrosinase activity and conformation : inhibition kinetics and computational simulations .
12512081	0	trifluoromethyl_ketones	6,29	gastric_lipase	40,54	trifluoromethyl ketones	gastric lipase	null	8513	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Novel trifluoromethyl_ketones as potent gastric_lipase inhibitors .
3649251	0	trifluoromethyl_ketones	68,91	human_leukocyte_elastase	40,64	trifluoromethyl ketones	human leukocyte elastase	null	1991	Chemical	Gene	Mechanism|nmod|START_ENTITY Mechanism|nmod|END_ENTITY	Mechanism of slow-binding inhibition of human_leukocyte_elastase by trifluoromethyl_ketones .
23297418	0	trigalactosyldiacylglycerol	54,81	TGD4	85,89	trigalactosyldiacylglycerol	TGD4	null	819881(Tax:3702)	Chemical	Gene	protein|amod|START_ENTITY protein|compound|END_ENTITY	The phosphatidic_acid binding site of the Arabidopsis trigalactosyldiacylglycerol 4 -LRB- TGD4 -RRB- protein required for lipid import into chloroplasts .
23725555	0	triglyceride	50,62	AMPK	23,27	triglyceride	AMPK	CHEBI:17855	78975(Tax:10116)	Chemical	Gene	accumulation|compound|START_ENTITY END_ENTITY|nmod|accumulation	The effects of chronic AMPK activation on hepatic triglyceride accumulation and glycerol_3-phosphate acyltransferase activity with high fat feeding .
10870325	0	triglyceride	102,114	APOCIII	89,96	triglyceride	APOCIII	CHEBI:17855	345	Chemical	Gene	level|amod|START_ENTITY END_ENTITY|nmod|level	DNA polymorphisms at the apolipoprotein A1-CIII loci in Taiwanese : correlation of plasma APOCIII with triglyceride level and body mass index .
20091124	0	triglyceride	47,59	ATGL	68,72	triglyceride	ATGL	CHEBI:17855	431066(Tax:9031)	Chemical	Gene	START_ENTITY|dobj|gene gene|appos|END_ENTITY	Identification and characterization of adipose triglyceride lipase -LRB- ATGL -RRB- gene in birds .
18375436	0	triglyceride	27,39	Adiponectin	0,11	triglyceride	Adiponectin	CHEBI:17855	9370	Chemical	Gene	reduces|dobj|START_ENTITY reduces|nsubj|END_ENTITY	Adiponectin reduces plasma triglyceride by increasing VLDL triglyceride catabolism .
3921638	0	triglyceride	75,87	Apolipoprotein_A-I	0,18	triglyceride	Apolipoprotein A-I	CHEBI:17855	25081(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY synthesis|dep|regulation synthesis|amod|END_ENTITY	Apolipoprotein_A-I synthesis in rat small intestine : regulation by dietary triglyceride and biliary lipid .
19321011	0	triglyceride	89,101	Apolipoprotein_A-IV	15,34	triglyceride	Apolipoprotein A-IV	CHEBI:17855	337	Chemical	Gene	formation|amod|START_ENTITY enterocytes|nmod|formation Stimulation|dep|enterocytes Stimulation|nmod|expression expression|amod|END_ENTITY	Stimulation of Apolipoprotein_A-IV expression in Caco-2 / TC7 enterocytes and reduction of triglyceride formation in 3T3-L1 adipocytes by potential anti-obesity Chinese herbal medicines .
24030551	0	triglyceride	55,67	Apolipoprotein_A-IV	0,19	triglyceride	Apolipoprotein A-IV	CHEBI:17855	11808(Tax:10090)	Chemical	Gene	secretion|amod|START_ENTITY enhances|dobj|secretion enhances|nsubj|expression expression|amod|END_ENTITY	Apolipoprotein_A-IV expression in mouse liver enhances triglyceride secretion and reduces hepatic lipid content by promoting very low density lipoprotein particle expansion .
3555115	0	triglyceride	70,82	Apolipoprotein_A-IV	0,19	triglyceride	Apolipoprotein A-IV	CHEBI:17855	25080(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY synthesis|dep|regulation synthesis|amod|END_ENTITY	Apolipoprotein_A-IV synthesis in rat intestine : regulation by dietary triglyceride .
12615678	0	triglyceride	63,75	Apolipoprotein_A5	0,17	triglyceride	Apolipoprotein A5	CHEBI:17855	116519	Chemical	Gene	levels|compound|START_ENTITY affects|dobj|levels gene|acl:relcl|affects END_ENTITY|appos|gene	Apolipoprotein_A5 , a newly identified gene that affects plasma triglyceride levels in humans and mice .
12637506	0	triglyceride	51,63	Apolipoprotein_A5	0,17	triglyceride	Apolipoprotein A5	CHEBI:17855	116519	Chemical	Gene	levels|compound|START_ENTITY determinant|nmod|levels END_ENTITY|appos|determinant	Apolipoprotein_A5 , a crucial determinant of plasma triglyceride levels , is highly responsive to peroxisome_proliferator-activated_receptor_alpha activators .
16954607	0	triglyceride	97,109	Apolipoprotein_A5	0,17	triglyceride	Apolipoprotein A5	CHEBI:17855	116519	Chemical	Gene	levels|amod|START_ENTITY circulating|dobj|levels elevated|xcomp|circulating elevated|nsubj|associates associates|amod|END_ENTITY	Apolipoprotein_A5 gene promoter region T-1131C polymorphism associates with elevated circulating triglyceride levels and confers susceptibility for development of ischemic_stroke .
18579034	0	triglyceride	42,54	Apolipoprotein_A5	1,18	triglyceride	Apolipoprotein A5	CHEBI:17855	116519	Chemical	Gene	metabolism|amod|START_ENTITY association|nmod|metabolism gene|dep|association gene|amod|END_ENTITY	-LSB- Apolipoprotein_A5 gene : association with triglyceride metabolism and cardiovascular_disease -RSB- .
22688093	0	triglyceride	116,128	Apolipoprotein_A5	0,17	triglyceride	Apolipoprotein A5	CHEBI:17855	116519	Chemical	Gene	levels|compound|START_ENTITY risk|nmod|levels associated|nmod|risk region-1131T|parataxis|associated region-1131T|compound|END_ENTITY	Apolipoprotein_A5 gene promoter region-1131T / C polymorphism is associated with risk of ischemic_stroke and elevated triglyceride levels : a meta-analysis .
22718631	0	triglyceride	70,82	Apolipoprotein_A5	0,17	triglyceride	Apolipoprotein A5	CHEBI:17855	116519	Chemical	Gene	content|compound|START_ENTITY modulates|dobj|content modulates|nsubj|END_ENTITY	Apolipoprotein_A5 internalized by human adipocytes modulates cellular triglyceride content .
26028042	0	triglyceride	60,72	Apolipoprotein_A5	0,17	triglyceride	Apolipoprotein A5	CHEBI:17855	116519	Chemical	Gene	metabolism|amod|START_ENTITY roles|nmod|metabolism END_ENTITY|dep|roles	Apolipoprotein_A5 : extracellular and intracellular roles in triglyceride metabolism .
26244076	0	triglyceride	129,141	Apolipoprotein_A5	19,36	triglyceride	Apolipoprotein A5	CHEBI:17855	116519	Chemical	Gene	START_ENTITY|nsubj|interaction interaction|nmod|polymorphism polymorphism|amod|END_ENTITY	The interaction of Apolipoprotein_A5 gene promoter region T-1131C polymorphism -LRB- rs12286037 -RRB- and lifestyle modification on plasma triglyceride levels in Japanese .
26244076	0	triglyceride	129,141	Apolipoprotein_A5	19,36	triglyceride	Apolipoprotein A5	CHEBI:17855	116519	Chemical	Gene	START_ENTITY|nsubj|interaction interaction|nmod|polymorphism polymorphism|amod|END_ENTITY	The interaction of Apolipoprotein_A5 gene promoter region T-1131C polymorphism -LRB- rs12286037 -RRB- and lifestyle modification on plasma triglyceride levels in Japanese .
3958612	0	triglyceride	73,85	Apolipoprotein_B	0,16	triglyceride	Apolipoprotein B	CHEBI:17855	54225(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY synthesis|dep|regulation synthesis|compound|END_ENTITY	Apolipoprotein_B synthesis in rat small intestine : regulation by dietary triglyceride and biliary lipid .
19448895	0	triglyceride	70,82	CYP7A1	15,21	triglyceride	CYP7A1	CHEBI:17855	1581	Chemical	Gene	START_ENTITY|nsubj|Association Association|nmod|END_ENTITY	Association of CYP7A1 -278 A > C polymorphism and the response of plasma triglyceride after dietary intervention in dyslipidemic patients .
16448557	0	triglyceride	54,66	DGAT1	104,109	triglyceride	DGAT1	CHEBI:17855	13350(Tax:10090)	Chemical	Gene	synthesis|amod|START_ENTITY disrupting|dobj|synthesis Enhancing|advcl|disrupting Lessons|dep|Enhancing Lessons|nmod|mice mice|acl|lacking lacking|dobj|END_ENTITY	Enhancing energy and glucose metabolism by disrupting triglyceride synthesis : Lessons from mice lacking DGAT1 .
16877777	0	triglyceride	62,74	DGAT1	29,34	triglyceride	DGAT1	CHEBI:17855	13350(Tax:10090)	Chemical	Gene	increases|dobj|START_ENTITY increases|nsubj|overexpression overexpression|nmod|END_ENTITY	Short-term overexpression of DGAT1 or DGAT2 increases hepatic triglyceride but not VLDL triglyceride or apoB production .
17510710	0	triglyceride	43,55	DGAT1	28,33	triglyceride	DGAT1	CHEBI:17855	13350(Tax:10090)	Chemical	Gene	synthesis|amod|START_ENTITY augments|dobj|synthesis augments|nsubj|Upregulation Upregulation|nmod|END_ENTITY	Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance .
19675136	0	triglyceride	24,36	DGAT1	106,111	triglyceride	DGAT1	CHEBI:17855	13350(Tax:10090)	Chemical	Gene	synthesis|amod|START_ENTITY coupling|nmod|synthesis coupling|nmod|END_ENTITY	Paradoxical coupling of triglyceride synthesis and fatty_acid oxidation in skeletal muscle overexpressing DGAT1 .
19778901	0	triglyceride	33,45	DGAT1	0,5	triglyceride	DGAT1	CHEBI:17855	13350(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|heart heart|compound|END_ENTITY	DGAT1 expression increases heart triglyceride content but ameliorates lipotoxicity .
21212659	0	triglyceride	44,56	DGAT1	92,97	triglyceride	DGAT1	CHEBI:17855	13350(Tax:10090)	Chemical	Gene	accumulation|amod|START_ENTITY protects|nmod|accumulation protects|parataxis|effect effect|nmod|activity activity|compound|END_ENTITY	Pomegranate juice protects macrophages from triglyceride accumulation : inhibitory effect on DGAT1 activity and on triglyceride biosynthesis .
23642106	0	triglyceride	16,28	DGAT1	73,78	triglyceride	DGAT1	CHEBI:17855	13350(Tax:10090)	Chemical	Gene	synthesis|amod|START_ENTITY Upregulation|nmod|synthesis Upregulation|nmod|END_ENTITY	Upregulation of triglyceride synthesis in skeletal muscle overexpressing DGAT1 .
24562909	0	triglyceride	85,97	Dgat1	76,81	triglyceride	Dgat1	CHEBI:17855	8694	Chemical	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	Dictyostelium_discoideum Dgat2 can substitute for the essential function of Dgat1 in triglyceride production but not in ether lipid synthesis .
16463611	0	triglyceride	47,59	Insulin	1,8	triglyceride	Insulin	CHEBI:17855	3630	Chemical	Gene	role|nmod|START_ENTITY resistance|dep|role resistance|compound|END_ENTITY	-LSB- Insulin resistance : the role of intramuscular triglyceride and the importance of physical activity -RSB- .
21344529	0	triglyceride	29,41	Insulin	0,7	triglyceride	Insulin	CHEBI:17855	3630	Chemical	Gene	accumulation|amod|START_ENTITY macrophage|dobj|accumulation macrophage|nsubj|increases increases|compound|END_ENTITY	Insulin increases macrophage triglyceride accumulation under diabetic_conditions through the down regulation of hormone sensitive lipase and adipose_triglyceride_lipase .
6373324	0	triglyceride	64,76	Insulin	0,7	triglyceride	Insulin	CHEBI:17855	3630	Chemical	Gene	removal|compound|START_ENTITY diabetics|nmod|removal resistance|nmod|diabetics resistance|compound|END_ENTITY	Insulin resistance in diabetics and non-diabetics with impaired triglyceride removal .
8142201	0	triglyceride	66,78	Insulin	0,7	triglyceride	Insulin	CHEBI:17855	3630	Chemical	Gene	concentrations|amod|START_ENTITY explained|nmod|concentrations explained|dobj|END_ENTITY	Insulin in ischaemic_heart_disease : are associations explained by triglyceride concentrations ?
9593779	0	triglyceride	64,76	Insulin	0,7	triglyceride	Insulin	CHEBI:17855	3630	Chemical	Gene	production|compound|START_ENTITY contribute|nmod|production contribute|nsubj|therapy therapy|compound|END_ENTITY	Insulin therapy in burn patients does not contribute to hepatic triglyceride production .
7720663	0	triglyceride	33,45	Interleukin-6	0,13	triglyceride	Interleukin-6	CHEBI:17855	24498(Tax:10116)	Chemical	Gene	secretion|compound|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Interleukin-6 stimulates hepatic triglyceride secretion in rats .
20721681	0	triglyceride	60,72	L-FABP	147,153	triglyceride	L-FABP	CHEBI:17855	2168	Chemical	Gene	START_ENTITY|nmod|cells cells|acl|transfected transfected|nmod|END_ENTITY	L-FABP T94A decreased fatty_acid uptake and altered hepatic triglyceride and cholesterol accumulation in Chang liver cells stably transfected with L-FABP .
10360951	0	triglyceride	49,61	MTP	121,124	triglyceride	MTP	CHEBI:17855	4547	Chemical	Gene	protein|amod|START_ENTITY overexpression|nmod|protein overexpression|dep|studies studies|nmod|role role|nmod|END_ENTITY	Adenovirus-mediated overexpression of microsomal triglyceride transfer protein -LRB- MTP -RRB- : mechanistic studies on the role of MTP in apolipoprotein_B-100 biogenesis .
10360951	0	triglyceride	49,61	MTP	80,83	triglyceride	MTP	CHEBI:17855	4547	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Adenovirus-mediated overexpression of microsomal triglyceride transfer protein -LRB- MTP -RRB- : mechanistic studies on the role of MTP in apolipoprotein_B-100 biogenesis .
10368443	2	triglyceride	572,584	MTP	603,606	triglyceride	MTP	CHEBI:17855	4547	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	We have identified contiguous conserved sequence motifs in alignments of insect apolipophorin II/I precursor -LRB- apoLp-II/I -RRB- , human apolipoprotein_B -LRB- apoB -RRB- , invertebrate and vertebrate vitellogenins -LRB- VTG -RRB- , and the large subunit of mammalian microsomal triglyceride transfer protein -LRB- MTP -RRB- .
10553017	0	triglyceride	37,49	MTP	68,71	triglyceride	MTP	CHEBI:17855	17777(Tax:10090)	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Hepatic overexpression of microsomal triglyceride transfer protein -LRB- MTP -RRB- results in increased in vivo secretion of VLDL triglycerides and apolipoprotein_B .
15519363	0	triglyceride	55,67	MTP	86,89	triglyceride	MTP	CHEBI:17855	17777(Tax:10090)	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Possible involvement of enhanced intestinal microsomal triglyceride transfer protein -LRB- MTP -RRB- gene expression in acceleration of lipid absorption by a western-type diet in apolipoprotein E knockout mice .
17524368	0	triglyceride	33,45	MTP	64,67	triglyceride	MTP	CHEBI:17855	17775(Tax:10090)	Chemical	Gene	protein|amod|START_ENTITY Modulation|nmod|protein Modulation|appos|END_ENTITY	Modulation of hepatic microsomal triglyceride transfer protein -LRB- MTP -RRB- induced by S-nitroso-N-acetylcysteine in ob/ob mice .
18482281	0	triglyceride	11,23	MTP	42,45	triglyceride	MTP	CHEBI:17855	4547	Chemical	Gene	protein|compound|START_ENTITY contributes|nsubj|protein contributes|dep|END_ENTITY	Microsomal triglyceride transfer protein -LRB- MTP -RRB- -493 G/T gene polymorphism contributes to fat liver_accumulation in HCV genotype 3 infected patients .
20510883	0	triglyceride	52,64	MTP	122,125	triglyceride	MTP	CHEBI:17855	17775(Tax:10090)	Chemical	Gene	responses|nmod|START_ENTITY responses|dep|roles roles|nmod|END_ENTITY	Mechanisms underlying different responses of plasma triglyceride to high-fat diets in hamsters and mice : roles of hepatic MTP and triglyceride secretion .
7658155	0	triglyceride	11,23	MTP	103,106	triglyceride	MTP	CHEBI:17855	4547	Chemical	Gene	regulation|amod|START_ENTITY regulation|dep|insulin insulin|dep|regulates regulates|dobj|expression expression|compound|END_ENTITY	Microsomal triglyceride transfer protein -LRB- MTP -RRB- regulation in HepG2 cells : insulin negatively regulates MTP gene expression .
7658155	0	triglyceride	11,23	MTP	42,45	triglyceride	MTP	CHEBI:17855	4547	Chemical	Gene	regulation|amod|START_ENTITY regulation|appos|END_ENTITY	Microsomal triglyceride transfer protein -LRB- MTP -RRB- regulation in HepG2 cells : insulin negatively regulates MTP gene expression .
19404482	0	triglyceride	77,89	PPAR-a	107,113	triglyceride	PPAR-a	CHEBI:17855	5465	Chemical	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	MBX-102 / JNJ39659100 , a novel non-TZD selective partial PPAR-y agonist lowers triglyceride independently of PPAR-a activation .
16282640	0	triglyceride	31,43	PPARalpha	0,9	triglyceride	PPARalpha	CHEBI:17855	19013(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|increases increases|compound|END_ENTITY	PPARalpha activation increases triglyceride mass and adipose_differentiation-related_protein in hepatocytes .
2382712	0	triglyceride	60,72	TNF	37,40	triglyceride	TNF	CHEBI:17855	103694380	Chemical	Gene	production|compound|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Diet affects the mechanisms by which TNF stimulates hepatic triglyceride production .
25244504	0	triglyceride	54,66	Urokinase-type_plasminogen_activator	0,36	triglyceride	Urokinase-type plasminogen activator	CHEBI:17855	18792(Tax:10090)	Chemical	Gene	synthesis|amod|START_ENTITY stimulates|dobj|synthesis stimulates|nsubj|END_ENTITY	Urokinase-type_plasminogen_activator -LRB- uPA -RRB- stimulates triglyceride synthesis in Huh7 hepatoma cells via p38-dependent upregulation of DGAT2 .
11108739	0	triglyceride	45,57	VLDL	40,44	triglyceride	VLDL	CHEBI:17855	54219(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|amod|END_ENTITY	LDL_receptor_deficiency unmasks altered VLDL triglyceride metabolism in VLDL_receptor transgenic and knockout mice .
24694356	0	triglyceride	74,86	apoB48	108,114	triglyceride	apoB48	CHEBI:17855	338	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|nmod|END_ENTITY	Static and turnover kinetic measurement of protein biomarkers involved in triglyceride metabolism including apoB48 and apoA5 by LC/MS/MS .
11181750	0	triglyceride	76,88	apolipoprotein_A-IV	14,33	triglyceride	apolipoprotein A-IV	CHEBI:17855	337	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|polymorphism polymorphism|amod|END_ENTITY	Effect of the apolipoprotein_A-IV Q360H polymorphism on postprandial plasma triglyceride clearance .
21127258	0	triglyceride	25,37	apolipoprotein_A-IV	58,77	triglyceride	apolipoprotein A-IV	CHEBI:17855	397681(Tax:9823)	Chemical	Gene	START_ENTITY|nmod|cells cells|amod|END_ENTITY	Regulation of microsomal triglyceride transfer protein by apolipoprotein_A-IV in newborn swine intestinal epithelial cells .
12417524	0	triglyceride	68,80	apolipoprotein_A5	16,33	triglyceride	apolipoprotein A5	CHEBI:17855	116519	Chemical	Gene	levels|compound|START_ENTITY influence|dobj|levels influence|nsubj|haplotypes haplotypes|amod|END_ENTITY	Two independent apolipoprotein_A5 haplotypes influence human plasma triglyceride levels .
15117734	0	triglyceride	46,58	apolipoprotein_A5	12,29	triglyceride	apolipoprotein A5	CHEBI:17855	66113(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Analysis Analysis|nmod|END_ENTITY	Analysis of apolipoprotein_A5 , c3 , and plasma triglyceride concentrations in genetically engineered mice .
15178420	0	triglyceride	13,25	apolipoprotein_A5	60,77	triglyceride	apolipoprotein A5	CHEBI:17855	116519	Chemical	Gene	Mechanism|nmod|START_ENTITY Mechanism|acl|lowering lowering|nmod|mice mice|acl|expressing expressing|dobj|END_ENTITY	Mechanism of triglyceride lowering in mice expressing human apolipoprotein_A5 .
15542401	0	triglyceride	147,159	apolipoprotein_A5	49,66	triglyceride	apolipoprotein A5	CHEBI:17855	116519	Chemical	Gene	metabolism|compound|START_ENTITY risk|nmod|metabolism associated|nmod|risk associated|nsubjpass|C C|nmod|gene gene|amod|END_ENTITY	A single nucleotide polymorphism -1131 T > C in the apolipoprotein_A5 gene is associated with an increased risk of coronary_artery_disease and alters triglyceride metabolism in Chinese .
16046221	0	triglyceride	135,147	apolipoprotein_A5	36,53	triglyceride	apolipoprotein A5	CHEBI:17855	116519	Chemical	Gene	levels|compound|START_ENTITY risk|nmod|levels associated|nmod|risk associated|nsubjpass|T T|nmod|gene gene|amod|END_ENTITY	A genetic variant c. 553G _ > _ T in the apolipoprotein_A5 gene is associated with an increased risk of coronary_artery_disease and altered triglyceride levels in a Chinese population .
17722232	0	triglyceride	82,94	apolipoprotein_A5	36,53	triglyceride	apolipoprotein A5	CHEBI:17855	116519	Chemical	Gene	START_ENTITY|nsubj|polymorphisms polymorphisms|nmod|attribution attribution|nmod:poss|END_ENTITY	DNA polymorphisms and haplotypes of apolipoprotein_A5 's attribution to the plasma triglyceride levels in Koreans .
20395964	0	triglyceride	62,74	apolipoprotein_A5	21,38	triglyceride	apolipoprotein A5	CHEBI:17855	116519	Chemical	Gene	concentration|amod|START_ENTITY effects|nmod|concentration effects|nmod|SNPs SNPs|amod|END_ENTITY	Different effects of apolipoprotein_A5 SNPs and haplotypes on triglyceride concentration in three ethnic origins .
21375366	0	triglyceride	59,71	apolipoprotein_A5	10,27	triglyceride	apolipoprotein A5	CHEBI:17855	116519	Chemical	Gene	levels|compound|START_ENTITY polymorphisms|nmod|levels polymorphisms|nsubj|Impact Impact|nmod|END_ENTITY	Impact of apolipoprotein_A5 -LRB- APOA5 -RRB- polymorphisms on serum triglyceride levels in schizophrenic patients under long-term atypical antipsychotic treatment .
22333545	0	triglyceride	109,121	apolipoprotein_A5	35,52	triglyceride	apolipoprotein A5	CHEBI:17855	116519	Chemical	Gene	polymorphism|nmod|START_ENTITY _|dobj|polymorphism _|nsubj|characteristics characteristics|nmod|> >|amod|END_ENTITY	-LSB- Distributional characteristics of apolipoprotein_A5 Gene c. 553G _ > _ T polymorphism and association with serum triglyceride in healthy Chinese Han and Uighur people -RSB- .
16750165	0	triglyceride	64,76	apolipoprotein_AV	18,35	triglyceride	apolipoprotein AV	CHEBI:17855	66113(Tax:10090)	Chemical	Gene	reduces|dobj|START_ENTITY reduces|nsubj|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of apolipoprotein_AV in the liver reduces plasma triglyceride and cholesterol but not HDL in ApoE deficient mice .
9915855	0	triglyceride	40,52	apolipoprotein_B	74,90	triglyceride	apolipoprotein B	CHEBI:17855	338	Chemical	Gene	protein|amod|START_ENTITY protein|nmod|END_ENTITY	A common binding site on the microsomal triglyceride transfer protein for apolipoprotein_B and protein_disulfide_isomerase .
20124557	0	triglyceride	30,42	apolipoprotein_D	10,26	triglyceride	apolipoprotein D	CHEBI:17855	11815(Tax:10090)	Chemical	Gene	metabolism|amod|START_ENTITY role|nmod|metabolism role|nmod|END_ENTITY	A role of apolipoprotein_D in triglyceride metabolism .
18029372	0	triglyceride	38,50	calcineurin_inhibitor	74,95	triglyceride	calcineurin inhibitor	CHEBI:17855	23523	Chemical	Gene	levels|compound|START_ENTITY effect|nmod|levels effect|nmod|END_ENTITY	The combined effect of pre-transplant triglyceride levels and the type of calcineurin_inhibitor in predicting the risk of new onset diabetes after renal transplantation .
23487794	0	triglyceride	35,47	caspase-1	8,17	triglyceride	caspase-1	CHEBI:17855	12362(Tax:10090)	Chemical	Gene	metabolism|amod|START_ENTITY Role|nmod|metabolism Role|nmod|END_ENTITY	Role of caspase-1 in regulation of triglyceride metabolism .
2345496	0	triglyceride	91,103	cholesteryl_ester_hydrolase	62,89	triglyceride	cholesteryl ester hydrolase	CHEBI:17855	65030(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|activation activation|nmod|END_ENTITY	Separation and differential activation of rat liver cytosolic cholesteryl_ester_hydrolase , triglyceride lipase and retinyl_palmitate hydrolase by cholestyramine and protein kinases .
12740481	0	triglyceride	41,53	familial_hypercholesterolemia	67,96	triglyceride	familial hypercholesterolemia	CHEBI:17855	3949	Chemical	Gene	phenotype|compound|START_ENTITY phenotype|nmod|END_ENTITY	Apolipoprotein_H variant modifies plasma triglyceride phenotype in familial_hypercholesterolemia : a molecular study in an eight-generation hyperlipidemic family .
17215532	0	triglyceride	25,37	familial_hypercholesterolemia	58,87	triglyceride	familial hypercholesterolemia	CHEBI:17855	3949	Chemical	Gene	START_ENTITY|dobj|protein protein|nmod|END_ENTITY	Inhibition of microsomal triglyceride transfer protein in familial_hypercholesterolemia .
21256834	0	triglyceride	27,39	familial_hypercholesterolemia	50,79	triglyceride	familial hypercholesterolemia	CHEBI:17855	3949	Chemical	Gene	levels|amod|START_ENTITY levels|nmod|END_ENTITY	Plasma HDL-cholesterol and triglyceride levels in familial_hypercholesterolemia : data from the MedPed CZ database and the Czech population .
22640645	0	triglyceride	14,26	glucocorticoid_receptor	41,64	triglyceride	glucocorticoid receptor	CHEBI:17855	2908	Chemical	Gene	metabolism|amod|START_ENTITY Regulation|nmod|metabolism Regulation|nmod|END_ENTITY	Regulation of triglyceride metabolism by glucocorticoid_receptor .
14564687	0	triglyceride	130,142	hepatic_lipase	101,115	triglyceride	hepatic lipase	CHEBI:17855	3990	Chemical	Gene	levels|compound|START_ENTITY gene|nmod|levels gene|amod|END_ENTITY	Interaction effect of Serine447Stop variant of the lipoprotein_lipase gene and C-514T variant of the hepatic_lipase gene on serum triglyceride levels in young adults : the Bogalusa Heart Study .
10426379	0	triglyceride	17,29	insulin	66,73	triglyceride	insulin	CHEBI:17855	3630	Chemical	Gene	content|compound|START_ENTITY determinant|nsubj|content determinant|nmod|resistance resistance|compound|END_ENTITY	Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans : a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents .
11872682	0	triglyceride	96,108	insulin	32,39	triglyceride	insulin	CHEBI:17855	3630	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|sensitivity sensitivity|amod|rosiglitazone rosiglitazone|nmod|END_ENTITY	The effects of rosiglitazone on insulin sensitivity , lipolysis , and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes .
11979383	0	triglyceride	67,79	insulin	38,45	triglyceride	insulin	CHEBI:17855	3630	Chemical	Gene	START_ENTITY|nsubj|Relationship Relationship|nmod|adiposity adiposity|nmod|resistance resistance|compound|END_ENTITY	Relationship of regional adiposity to insulin resistance and serum triglyceride levels in nonobese Japanese type 2 diabetic patients .
12643176	0	triglyceride	16,28	insulin	68,75	triglyceride	insulin	CHEBI:17855	3630	Chemical	Gene	START_ENTITY|dep|marker marker|nmod|resistance resistance|compound|END_ENTITY	Skeletal muscle triglyceride : marker or mediator of obesity-induced insulin resistance in type_2_diabetes_mellitus ?
12716735	0	triglyceride	25,37	insulin	63,70	triglyceride	insulin	CHEBI:17855	3630	Chemical	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Regulation of microsomal triglyceride transfer protein gene by insulin in HepG2 cells : roles of MAPKerk and MAPKp38 .
14681834	0	triglyceride	58,70	insulin	104,111	triglyceride	insulin	CHEBI:17855	3630	Chemical	Gene	concentrations|compound|START_ENTITY elevates|dobj|concentrations elevates|advcl|affecting affecting|dobj|sensitivity sensitivity|compound|END_ENTITY	Short-term administration of isotretinoin elevates plasma triglyceride concentrations without affecting insulin sensitivity in healthy humans .
17911339	0	triglyceride	23,35	insulin	66,73	triglyceride	insulin	CHEBI:17855	3630	Chemical	Gene	associated|nsubjpass|START_ENTITY associated|nmod|resistance resistance|compound|END_ENTITY	Increased intrahepatic triglyceride is associated with peripheral insulin resistance : in vivo MR imaging and spectroscopy studies .
19208729	0	triglyceride	164,176	insulin	135,142	triglyceride	insulin	CHEBI:17855	3630	Chemical	Gene	responses|compound|START_ENTITY resistance|nmod|responses resistance|compound|END_ENTITY	Endocrine and metabolic effects of consuming fructose - and glucose-sweetened beverages with meals in obese men and women : influence of insulin resistance on plasma triglyceride responses .
195754	0	triglyceride	113,125	insulin	143,150	triglyceride	insulin	CHEBI:17855	3630	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Lipoprotein concentrations in untreated adult onset diabetes_mellitus and the relationship of the fasting plasma triglyceride concentration to insulin secretion .
19926919	0	triglyceride	48,60	insulin	10,17	triglyceride	insulin	CHEBI:17855	3630	Chemical	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Decreased insulin secretion and accumulation of triglyceride in beta cells overexpressing a dominant-negative form of AMP-activated protein kinase .
2065859	0	triglyceride	13,25	insulin	172,179	triglyceride	insulin	CHEBI:17855	3630	Chemical	Gene	response|compound|START_ENTITY altered|nsubjpass|response altered|nmod|deterioration deterioration|nmod|replacement replacement|compound|END_ENTITY	Postprandial triglyceride response in type 1 -LRB- insulin-dependent -RRB- diabetes_mellitus is not altered by short-term deterioration in glycaemic control or level of postprandial insulin replacement .
24732283	0	triglyceride	6,18	insulin	64,71	triglyceride	insulin	CHEBI:17855	3630	Chemical	Gene	levels|compound|START_ENTITY correlated|nsubj|levels correlated|nmod|secretion secretion|compound|END_ENTITY	Serum triglyceride levels correlated with the rate of change in insulin secretion over two years in prediabetic subjects .
24914633	0	triglyceride	135,147	insulin	95,102	triglyceride	insulin	CHEBI:17855	3630	Chemical	Gene	profiles|amod|START_ENTITY humans|nmod|profiles provides|nmod|humans provides|dobj|indicator indicator|nmod|resistance resistance|compound|END_ENTITY	Serum fatty_acid profiling within distinct lipid fractions provides a more robust indicator of insulin resistance in humans than total triglyceride and fatty_acid profiles .
7752906	0	triglyceride	11,23	insulin	110,117	triglyceride	insulin	CHEBI:17855	3630	Chemical	Gene	affect|nsubj|START_ENTITY affect|dobj|effect effect|nmod|END_ENTITY	Decreasing triglyceride by gemfibrozil therapy does not affect the glucoregulatory or antilipolytic effect of insulin in nondiabetic subjects with mild hypertriglyceridemia .
9288540	0	triglyceride	56,68	insulin	12,19	triglyceride	insulin	CHEBI:17855	3630	Chemical	Gene	metabolism|amod|START_ENTITY regulation|nmod|metabolism role|nmod|regulation role|nmod|END_ENTITY	The role of insulin and proinsulin in the regulation of triglyceride metabolism .
935627	0	triglyceride	28,40	insulin	10,17	triglyceride	insulin	CHEBI:17855	3630	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of insulin on plasma triglyceride concentration in hepatectomized geese .
3415847	0	triglyceride	44,56	lipase	57,63	triglyceride	lipase	CHEBI:17855	17374477	Chemical	Gene	START_ENTITY|dobj|production production|amod|END_ENTITY	The Tween_80 reaction does not correlate to triglyceride lipase production of Staphylococcus_aureus .
7075586	0	triglyceride	25,37	lipase	38,44	triglyceride	lipase	CHEBI:17855	291437(Tax:10116)	Chemical	Gene	study|nmod|START_ENTITY END_ENTITY|nsubj|study	Kinetic study of hepatic triglyceride lipase from rat liver soluble fraction .
10450932	0	triglyceride	114,126	lipid_transfer_protein_I	89,113	triglyceride	lipid transfer protein I	CHEBI:17855	1071	Chemical	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Cyclosporine transfer from low - and high-density lipoproteins is partially influenced by lipid_transfer_protein_I triglyceride transfer activity .
11702219	0	triglyceride	120,132	lipoprotein_lipase	75,93	triglyceride	lipoprotein lipase	CHEBI:17855	4023	Chemical	Gene	levels|compound|START_ENTITY gene|nmod|levels gene|amod|END_ENTITY	Physical activity modulates the combined effect of a common variant of the lipoprotein_lipase gene and smoking on serum triglyceride levels and high-density lipoprotein cholesterol in men .
1640846	0	triglyceride	43,55	lipoprotein_lipase	94,112	triglyceride	lipoprotein lipase	CHEBI:17855	4023	Chemical	Gene	Metabolism|nmod|START_ENTITY Metabolism|dep|role role|nmod|END_ENTITY	Metabolism of very-low-density lipoprotein triglyceride by human placental cells : the role of lipoprotein_lipase .
227752	0	triglyceride	37,49	lipoprotein_lipase	8,26	triglyceride	lipoprotein lipase	CHEBI:17855	4023	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of lipoprotein_lipase in plasma triglyceride removal .
3677597	0	triglyceride	87,99	lipoprotein_lipase	56,74	triglyceride	lipoprotein lipase	CHEBI:17855	24539(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Effects of dietary saturated and polyunsaturated fat on lipoprotein_lipase and hepatic triglyceride lipase activity .
6694974	0	triglyceride	58,70	lipoprotein_lipase	27,45	triglyceride	lipoprotein lipase	CHEBI:17855	24539(Tax:10116)	Chemical	Gene	activities|amod|START_ENTITY activities|amod|END_ENTITY	Effects of diet and age on lipoprotein_lipase and hepatic triglyceride lipase activities in the rat .
7451832	0	triglyceride	28,40	lipoprotein_lipase	74,92	triglyceride	lipoprotein lipase	CHEBI:17855	24539(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|activity activity|compound|END_ENTITY	Relationship between plasma triglyceride concentration and adipose tissue lipoprotein_lipase activity in rats of different ages .
25605429	0	triglyceride	17,29	miR-21	0,6	triglyceride	miR-21	CHEBI:17855	406991	Chemical	Gene	metabolism|compound|START_ENTITY regulates|dobj|metabolism regulates|nsubj|END_ENTITY	miR-21 regulates triglyceride and cholesterol metabolism in non-alcoholic_fatty_liver_disease by targeting HMGCR .
923094	1	triglyceride	212,224	protamine_sulphate	247,265	triglyceride	lipoprotein lipase	CHEBI:17855	4023	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	The rate of inactivation of triglyceride hydrolase activity by protamine_sulphate was determined in pooled , normal , post-heparin plasma .
12937897	0	triglycerides	110,123	APOA5	70,75	triglycerides	APOA5	MESH:D014280	116519	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|C C|nmod|gene gene|appos|END_ENTITY	The single nucleotide polymorphism -1131 T > C in the apolipoprotein_A5 -LRB- APOA5 -RRB- gene is associated with elevated triglycerides in patients with hyperlipidemia .
15604515	0	triglycerides	37,50	APOA5	0,5	triglycerides	APOA5	MESH:D014280	116519	Chemical	Gene	influence|dobj|START_ENTITY influence|nsubj|polymorphisms polymorphisms|compound|END_ENTITY	APOA5 polymorphisms influence plasma triglycerides in young , healthy African Americans and whites of the CARDIA Study .
16401313	0	triglycerides	93,106	APOA5	45,50	triglycerides	APOA5	MESH:D014280	116519	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Interaction of the G182C polymorphism in the APOA5 gene and fasting plasma glucose on plasma triglycerides in Type 2 diabetic subjects .
16636175	1	triglycerides	284,297	APOA5	241,246	triglycerides	APOA5	MESH:D014280	116519	Chemical	Gene	associated|nmod|START_ENTITY gene|acl:relcl|associated gene|appos|END_ENTITY	BACKGROUND : Apolipoprotein_A5 gene -LRB- APOA5 -RRB- variation is associated with plasma triglycerides -LRB- TGs -RRB- .
18789138	0	triglycerides	93,106	APOA5	4,9	triglycerides	APOA5	MESH:D014280	116519	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|allele allele|compound|END_ENTITY	The APOA5 Trp19 allele is associated with metabolic_syndrome via its association with plasma triglycerides .
20688329	0	triglycerides	78,91	APOA5	23,28	triglycerides	APOA5	MESH:D014280	116519	Chemical	Gene	predisposes|nmod|START_ENTITY predisposes|nsubj|gene gene|compound|END_ENTITY	The apolipoprotein_A5 -LRB- APOA5 -RRB- gene predisposes Caucasian children to elevated triglycerides and vitamin_E -LRB- Four Provinces Study -RRB- .
24387992	0	triglycerides	47,60	APOA5	3,8	triglycerides	APOA5	MESH:D014280	116519	Chemical	Gene	associated|nmod|START_ENTITY variant|acl|associated variant|nmod:poss|END_ENTITY	An APOA5 3 ' UTR variant associated with plasma triglycerides triggers APOA5 downregulation by creating a functional miR-485-5p binding site .
24387992	0	triglycerides	47,60	APOA5	70,75	triglycerides	APOA5	MESH:D014280	116519	Chemical	Gene	associated|nmod|START_ENTITY variant|acl|associated triggers|nsubj|variant triggers|dobj|downregulation downregulation|compound|END_ENTITY	An APOA5 3 ' UTR variant associated with plasma triglycerides triggers APOA5 downregulation by creating a functional miR-485-5p binding site .
15764642	0	triglycerides	80,93	APOE	35,39	triglycerides	APOE	MESH:D014280	348	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Additive effects of the PPARgamma , APOE , and FABP-2 genes in increasing daylong triglycerides of normolipidemic women to concentrations comparable to those in men .
24097412	0	triglycerides	39,52	APOE	0,4	triglycerides	APOE	MESH:D014280	348	Chemical	Gene	correlation|nmod|START_ENTITY modulates|dobj|correlation modulates|nsubj|END_ENTITY	APOE modulates the correlation between triglycerides , cholesterol , and CHD through pleiotropy , and gene-by-gene interactions .
16627799	0	triglycerides	83,96	Adipocyte_differentiation-related_protein	0,41	triglycerides	Adipocyte differentiation-related protein	MESH:D014280	298199(Tax:10116)	Chemical	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Adipocyte_differentiation-related_protein promotes fatty_acid storage in cytosolic triglycerides and inhibits secretion of very low-density lipoproteins .
23000317	0	triglycerides	35,48	ApoA5	15,20	triglycerides	ApoA5	MESH:D014280	116519	Chemical	Gene	modulation|nmod|START_ENTITY modulation|amod|END_ENTITY	The paradox of ApoA5 modulation of triglycerides : evidence from clinical and basic research .
15090553	0	triglycerides	21,34	ApoAV	0,5	triglycerides	ApoAV	MESH:D014280	66113(Tax:10090)	Chemical	Gene	reduces|dobj|START_ENTITY reduces|nsubj|END_ENTITY	ApoAV reduces plasma triglycerides by inhibiting very low density lipoprotein-triglyceride -LRB- VLDL-TG -RRB- production and stimulating lipoprotein_lipase-mediated VLDL-TG hydrolysis .
20580041	0	triglycerides	48,61	Apolipoprotein_C-I	0,18	triglycerides	Apolipoprotein C-I	MESH:D014280	341	Chemical	Gene	genotype|nmod|START_ENTITY genotype|amod|END_ENTITY	Apolipoprotein_C-I genotype and serum levels of triglycerides , C-reactive_protein and coronary heart_disease .
15604524	0	triglycerides	74,87	Apolipoprotein_L-I	0,18	triglycerides	Apolipoprotein L-I	MESH:D014280	8542	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	Apolipoprotein_L-I is positively associated with hyperglycemia and plasma triglycerides in CAD patients with low HDL .
15832099	0	triglycerides	60,73	C-reactive_protein	19,37	triglycerides	C-reactive protein	MESH:D014280	1401	Chemical	Gene	elevation|nmod|START_ENTITY elevation|amod|END_ENTITY	High prevalence of C-reactive_protein elevation with normal triglycerides -LRB- 100-149 mg/dL -RRB- : are triglyceride levels below 100 mg/dL more optimal in coronary_heart_disease risk assessment ?
5882704	0	triglycerides	157,170	C14	136,139	triglycerides	C14	MESH:D014280	29530(Tax:10116)	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- `` In vivo '' incorporation of C14 stearic and H3 oleic acids into various phospholipids of rat intestinal mucosa after ingestion of mixed C14 stearic-H3 oleic triglycerides -RSB- .
8981511	0	triglycerides	43,56	CCK	92,95	triglycerides	CCK	MESH:D014280	885	Chemical	Gene	fatty_acids|nmod|START_ENTITY responsible|nsubj|fatty_acids responsible|nmod|release release|nmod|END_ENTITY	Intraduodenal free fatty_acids rather than triglycerides are responsible for the release of CCK in humans .
9696717	0	triglycerides	33,46	CCK	95,98	triglycerides	CCK	MESH:D014280	885	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|role role|nmod|END_ENTITY	Effect of medium - and long-chain triglycerides on lower esophageal sphincter pressure : role of CCK .
21945496	0	triglycerides	145,158	GATA4	113,118	triglycerides	GATA4	MESH:D014280	2626	Chemical	Gene	polymorphisms|nmod|START_ENTITY polymorphisms|nummod|END_ENTITY	Look beyond one 's own nose : combination of information from publicly available sources reveals an association of GATA4 polymorphisms with plasma triglycerides .
26136510	0	triglycerides	99,112	GCKR	68,72	triglycerides	GCKR	MESH:D014280	2646	Chemical	Gene	polymorphism|nmod|START_ENTITY polymorphism|amod|END_ENTITY	n-3 long-chain polyunsatured fatty_acids modulate the impact of the GCKR Pro446Leu polymorphism on triglycerides in adolescents .
10690948	0	triglycerides	95,108	Insulin	0,7	triglycerides	Insulin	MESH:D014280	3630	Chemical	Gene	fatty_acids|nmod|START_ENTITY correlates|nmod|fatty_acids correlates|nsubj|resistance resistance|compound|END_ENTITY	Insulin resistance directly correlates with increased saturated fatty_acids in skeletal muscle triglycerides .
19833891	0	triglycerides	62,75	Insulin	0,7	triglycerides	Insulin	MESH:D014280	3630	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|resistance resistance|compound|END_ENTITY	Insulin resistance is associated with higher intramyocellular triglycerides in type I but not type II myocytes concomitant with higher ceramide content .
19910634	0	triglycerides	44,57	apolipoprotein_A-II	6,25	triglycerides	apolipoprotein A-II	MESH:D014280	336	Chemical	Gene	determines|dobj|START_ENTITY determines|nsubj|END_ENTITY	Human apolipoprotein_A-II determines plasma triglycerides by regulating lipoprotein_lipase activity and high-density lipoprotein proteome .
12937897	0	triglycerides	110,123	apolipoprotein_A5	51,68	triglycerides	apolipoprotein A5	MESH:D014280	116519	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubjpass|C C|nmod|gene gene|amod|END_ENTITY	The single nucleotide polymorphism -1131 T > C in the apolipoprotein_A5 -LRB- APOA5 -RRB- gene is associated with elevated triglycerides in patients with hyperlipidemia .
16636175	0	triglycerides	95,108	apolipoprotein_A5	54,71	triglycerides	apolipoprotein A5	MESH:D014280	116519	Chemical	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Dietary intake of n-6_fatty_acids modulates effect of apolipoprotein_A5 gene on plasma fasting triglycerides , remnant lipoprotein concentrations , and lipoprotein particle size : the Framingham Heart Study .
17188674	0	triglycerides	72,85	apolipoprotein_A5	16,33	triglycerides	apolipoprotein A5	MESH:D014280	116519	Chemical	Gene	serum|dobj|START_ENTITY Relationship|acl|serum Relationship|nmod|levels levels|amod|END_ENTITY	Relationship of apolipoprotein_A5 and apolipoprotein_C3 levels to serum triglycerides in patients with type 2 diabetes .
20688329	0	triglycerides	78,91	apolipoprotein_A5	4,21	triglycerides	apolipoprotein A5	MESH:D014280	116519	Chemical	Gene	predisposes|nmod|START_ENTITY predisposes|nsubj|gene gene|amod|END_ENTITY	The apolipoprotein_A5 -LRB- APOA5 -RRB- gene predisposes Caucasian children to elevated triglycerides and vitamin_E -LRB- Four Provinces Study -RRB- .
8727649	0	triglycerides	23,36	calbindin-D9k	40,53	triglycerides	calbindin-D9k	MESH:D014280	795	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of medium-chain triglycerides on calbindin-D9k expression in the intestine .
2366103	0	triglycerides	18,31	cholecystokinin	42,57	triglycerides	cholecystokinin	MESH:D014280	25298(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|compound|END_ENTITY	Effect of various triglycerides on plasma cholecystokinin levels in rats .
6695835	0	triglycerides	42,55	cholecystokinin	97,112	triglycerides	cholecystokinin	MESH:D014280	885	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of equimolar amounts of long-chain triglycerides and medium-chain triglycerides on plasma cholecystokinin and gallbladder contraction .
27086060	0	triglycerides	50,63	elastase_1	22,32	triglycerides	elastase 1	MESH:D014280	23436	Chemical	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of faecal elastase_1 with non-fasting triglycerides in type 2 diabetes .
27086060	0	triglycerides	50,63	elastase_1	22,32	triglycerides	elastase 1	MESH:D014280	23436	Chemical	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of faecal elastase_1 with non-fasting triglycerides in type 2 diabetes .
12187392	0	triglycerides	16,29	insulin	77,84	triglycerides	insulin	MESH:D014280	3630	Chemical	Gene	lowering|compound|START_ENTITY associated|nsubjpass|lowering associated|nmod|improvement improvement|nmod|sensitivity sensitivity|compound|END_ENTITY	Skeletal muscle triglycerides lowering is associated with net improvement of insulin sensitivity , TNF-alpha reduction and GLUT4 expression enhancement .
15975102	0	triglycerides	13,26	insulin	66,73	triglycerides	insulin	MESH:D014280	3630	Chemical	Gene	associated|nsubjpass|START_ENTITY associated|nmod|need need|nmod|requirement requirement|compound|END_ENTITY	Lower plasma triglycerides are associated with increased need for insulin requirement in poorly controlled Type 2 diabetic patients .
17391174	0	triglycerides	83,96	insulin	110,117	triglycerides	insulin	MESH:D014280	3630	Chemical	Gene	subjects|nmod|START_ENTITY cholesterol|nmod|subjects cholesterol|dep|role role|nmod|resistance resistance|compound|END_ENTITY	Low serum high-density lipoprotein cholesterol in obese subjects with normal serum triglycerides : the role of insulin resistance and inflammatory cytokines .
206144	1	triglycerides	179,192	insulin	154,161	triglycerides	insulin	MESH:D014280	3630	Chemical	Gene	growth_hormone|nummod|START_ENTITY growth_hormone|compound|END_ENTITY	Glucose , insulin , growth_hormone , triglycerides , and Premarin .
20852089	0	triglycerides	43,56	insulin	62,69	triglycerides	insulin	MESH:D014280	3630	Chemical	Gene	START_ENTITY|nmod|infusion infusion|compound|END_ENTITY	Rapid reduction of severely elevated serum triglycerides with insulin infusion , gemfibrozil and niacin .
21528471	2	triglycerides	416,429	insulin	454,461	triglycerides	insulin	MESH:D014280	3630	Chemical	Gene	children|appos|START_ENTITY HDL-cholesterol|nsubj|children measured|advcl|HDL-cholesterol measured|nsubjpass|END_ENTITY	MATERIAL AND METHODS : In 78 obese children -LRB- 42 girls , 36 boys -RRB- , mean age 14.6 3.5 years , blood pressure , total cholesterol , triglycerides , HDL-cholesterol -LRB- HDL -RRB- , insulin and glucose at fasting state as well as in OGTT were measured .
22720879	0	triglycerides	23,36	insulin	67,74	triglycerides	insulin	MESH:D014280	3630	Chemical	Gene	Vaccenic_acid|nmod|START_ENTITY associated|nsubjpass|Vaccenic_acid associated|nmod|markers markers|nmod|resistance resistance|compound|END_ENTITY	Vaccenic_acid in serum triglycerides is associated with markers of insulin resistance in men .
22854916	0	triglycerides	49,62	insulin	14,21	triglycerides	insulin	MESH:D014280	3630	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|resistance resistance|compound|END_ENTITY	The effect of insulin resistance on postprandial triglycerides in Korean type 2 diabetic patients .
24824245	0	triglycerides	27,40	insulin	123,130	triglycerides	insulin	MESH:D014280	3630	Chemical	Gene	Triglycerides|nmod|START_ENTITY better|nsubj|Triglycerides better|ccomp|identify identify|dobj|resistance resistance|compound|END_ENTITY	Triglycerides and ratio of triglycerides to high-density lipoprotein cholesterol are better than liver enzymes to identify insulin resistance in urban middle-aged and older non-obese Chinese without diabetes .
26727147	0	triglycerides	58,71	insulin	88,95	triglycerides	insulin	MESH:D014280	3630	Chemical	Gene	START_ENTITY|nmod|changes changes|nmod|resistance resistance|compound|END_ENTITY	Synergistic association of changes in serum uric_acid and triglycerides with changes in insulin resistance after walking exercise in community-dwelling older women .
2698352	0	triglycerides	75,88	insulin	4,11	triglycerides	insulin	MESH:D014280	3630	Chemical	Gene	START_ENTITY|nsubj|response response|compound|END_ENTITY	The insulin response to oral glucose , concentrations of total cholesterol , triglycerides and uric_acid in women with idiopathic_hirsutism .
5548559	0	triglycerides	49,62	insulin	15,22	triglycerides	insulin	MESH:D014280	3630	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Stimulation Stimulation|nmod|END_ENTITY	Stimulation of insulin secretion by medium-chain triglycerides in patients with cirrhosis .
6348062	0	triglycerides	39,52	insulin	168,175	triglycerides	insulin	MESH:D014280	3630	Chemical	Gene	substitution|nmod|START_ENTITY substitution|dep|effects effects|nmod|resistance resistance|compound|END_ENTITY	Eucaloric substitution of medium chain triglycerides for dietary long chain fatty_acids in acquired total_lipodystrophy : effects on hyperlipoproteinemia and endogenous insulin resistance .
8458531	0	triglycerides	12,25	insulin	105,112	triglycerides	insulin	MESH:D014280	3630	Chemical	Gene	Lowering|nmod|START_ENTITY Lowering|dep|affects affects|dobj|effect effect|nmod|END_ENTITY	Lowering of triglycerides by gemfibrozil affects neither the glucoregulatory nor antilipolytic effect of insulin in type 2 -LRB- non-insulin-dependent -RRB- diabetic patients .
873070	0	triglycerides	65,78	insulin	21,28	triglycerides	insulin	MESH:D014280	3630	Chemical	Gene	_|nmod|START_ENTITY _|nsubj|effect effect|nmod|3-piridyl 3-piridyl|compound|END_ENTITY	Short-term effect of insulin and 5 -LRB- 3-piridyl -RRB- _ tetrazole on serum triglycerides in insulin-dependent diabetic patients .
15071157	0	triglycerides	56,69	pancreatic_lipase	14,31	triglycerides	pancreatic lipase	MESH:D014280	25702(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of pancreatic_lipase by dietary medium chain triglycerides in the weanling rat .
4011957	0	triglycerides	23,36	pancreatic_polypeptide	76,98	triglycerides	pancreatic polypeptide	MESH:D014280	5539	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of medium-chain triglycerides and long-chain triglycerides on plasma pancreatic_polypeptide secretion in man .
22674772	0	triglycerides	5,18	paraoxonase_1	42,55	triglycerides	paraoxonase 1	MESH:D014280	5444	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|END_ENTITY	VLDL triglycerides inhibit HDL-associated paraoxonase_1 -LRB- PON1 -RRB- activity : in vitro and in vivo studies .
17547452	0	trihexyltetradecylphosphonium_chloride	55,93	CO2	121,124	trihexyltetradecylphosphonium chloride	CO2	MESH:C559940	717	Chemical	Gene	system|amod|START_ENTITY system|compound|END_ENTITY	Limiting partition coefficients of solutes in biphasic trihexyltetradecylphosphonium_chloride ionic liquid-supercritical CO2 system : measurement and LSER-based correlation .
6489520	0	trihydroxy_pipecolic_acid	79,104	beta-D-glucuronidase	29,49	trihydroxy pipecolic acid	beta-D-glucuronidase	null	2990	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Specific inhibition of human beta-D-glucuronidase and alpha-L-iduronidase by a trihydroxy_pipecolic_acid of plant origin .
15571324	0	triiodo-L-thyronine	97,116	connexin-43	9,20	triiodo-L-thyronine	connexin-43	null	24392(Tax:10116)	Chemical	Gene	exposed|xcomp|START_ENTITY exposed|nsubj|END_ENTITY	Enhanced connexin-43 and alpha-sarcomeric actin expression in cultured heart myocytes exposed to triiodo-L-thyronine .
2737142	0	triiodothyronine	54,70	GH	95,97	triiodothyronine	GH	MESH:D014284	81668(Tax:10116)	Chemical	Gene	growth_hormone|amod|START_ENTITY growth_hormone|appos|END_ENTITY	Heat shock of cultured GC cells enhances the level of triiodothyronine induced growth_hormone -LRB- GH -RRB- and GH messenger ribonucleic_acid .
3623420	0	triiodothyronine	70,86	Growth_hormone	0,14	triiodothyronine	Growth hormone	MESH:D014284	378781(Tax:9031)	Chemical	Gene	stimulates|nmod|START_ENTITY stimulates|nsubj|END_ENTITY	Growth_hormone stimulates the peripheral conversion of thyroxine into triiodothyronine by increasing the liver 5 ' - monodeiodinase activity in the fasted and normal fed chicken .
7828350	0	triiodothyronine	106,122	Growth_hormone	0,14	triiodothyronine	Growth hormone	MESH:D014284	2688	Chemical	Gene	stimulates|acl|START_ENTITY stimulates|amod|END_ENTITY	Growth_hormone administration stimulates energy expenditure and extrathyroidal conversion of thyroxine to triiodothyronine in a dose-dependent manner and suppresses circadian thyrotrophin levels : studies in GH-deficient adults .
7614740	0	triiodothyronine	17,33	MHC_class_II_antigen	91,111	triiodothyronine	MHC class II antigen	MESH:D014284	3128	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	The influence of triiodothyronine , thyroxine , thyrotropin , and methimazole on thyroid cell MHC_class_II_antigen expression .
3926522	0	triiodothyronine	94,110	T3	81,83	triiodothyronine	T3	MESH:D014284	24754(Tax:10116)	Chemical	Gene	triiodothyronine|appos|START_ENTITY triiodothyronine|appos|END_ENTITY	Effect of prednison therapy on serum levels of thyroxine _ -LRB- T4 -RRB- , triiodothyronine -LRB- T3 -RRB- , reverse triiodothyronine -LRB- rT3 -RRB- , T3-binding capacity , basal TSH level and TSH response to thyreoliberin -LRB- TRH -RRB- in children .
554102	0	triiodothyronine	6,22	T3	24,26	triiodothyronine	T3	MESH:D014284	24754(Tax:10116)	Chemical	Gene	syndrome|compound|START_ENTITY syndrome|appos|END_ENTITY	-LSB- `` Low triiodothyronine -LRB- T3 -RRB- syndrome '' : `` thyroxine -LRB- T4 -RRB- euthyroidism '' evidence -LRB- author 's transl -RRB- -RSB- .
6820292	0	triiodothyronine	55,71	T3	73,75	triiodothyronine	T3	MESH:D014284	24754(Tax:10116)	Chemical	Gene	circulating|dobj|START_ENTITY Comparison|advcl|circulating Comparison|dep|END_ENTITY	-LSB- Comparison between spontaneous changes in circulating triiodothyronine -LRB- T3 and reverse-T3 -RRB- and those induced by acute intravenous administration of thyroliberin -RSB- .
7208169	0	triiodothyronine	87,103	T3	105,107	triiodothyronine	T3	MESH:D014284	24754(Tax:10116)	Chemical	Gene	thyroxine|acl|START_ENTITY conversion|nmod|thyroxine growth_hormone|nmod|conversion growth_hormone|appos|END_ENTITY	Action of human growth_hormone -LRB- hGH -RRB- on extrathyroidal conversion of thyroxine -LRB- T4 -RRB- to triiodothyronine -LRB- T3 -RRB- in children with hypopituitarism .
7227325	2	triiodothyronine	63,79	T3	136,138	triiodothyronine	T3	MESH:D014284	24754(Tax:10116)	Chemical	Gene	Response|nmod|START_ENTITY Response|nmod|END_ENTITY	Response of serum triiodothyronine -LRB- T3 -RRB- and reverse triiodothyronine -LRB- rT3 -RRB- to administered T3 .
1572297	0	triiodothyronine	136,152	Thyrotropin-releasing_hormone	0,29	triiodothyronine	Thyrotropin-releasing hormone	MESH:D014284	25569(Tax:10116)	Chemical	Gene	dependent|nmod|START_ENTITY dependent|nsubj|expression expression|amod|END_ENTITY	Thyrotropin-releasing_hormone gene expression in the hypothalamic paraventricular nucleus is dependent upon feedback regulation by both triiodothyronine and thyroxine .
8612408	0	triiodothyronine	121,137	Thyrotropin-releasing_hormone	0,29	triiodothyronine	Thyrotropin-releasing hormone	MESH:D014284	7200	Chemical	Gene	increasing|dobj|START_ENTITY strategy|acl|increasing test|nmod|strategy END_ENTITY|nmod|test	Thyrotropin-releasing_hormone in critical_illness : from a dopamine-dependent test to a strategy for increasing low serum triiodothyronine , prolactin , and growth_hormone concentrations .
20094971	0	triiodothyronine	10,26	adiponectin	30,41	triiodothyronine	adiponectin	MESH:D014284	9370	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effect of triiodothyronine on adiponectin expression and leptin release by white_adipose_tissue of normal rats .
7851842	0	triiodothyronine	11,27	angiotensin_converting_enzyme	67,96	triiodothyronine	angiotensin converting enzyme	MESH:D014284	24310(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of triiodothyronine and dexamethasone on plasma and tissue angiotensin_converting_enzyme in the rat .
3136772	0	triiodothyronine	14,30	apolipoprotein_A-I	38,56	triiodothyronine	apolipoprotein A-I	MESH:D014284	25081(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of triiodothyronine on rat apolipoprotein_A-I and A-IV gene transcription .
8130892	0	triiodothyronine	108,124	corticosteroid-binding_globulin	68,99	triiodothyronine	corticosteroid-binding globulin	MESH:D014284	866	Chemical	Gene	mRNA|nmod|START_ENTITY mRNA|amod|END_ENTITY	Stimulation of sex_hormone-binding_globulin mRNA and attenuation of corticosteroid-binding_globulin mRNA by triiodothyronine in human hepatoma cells .
9220022	0	triiodothyronine	11,27	glucokinase	49,60	triiodothyronine	glucokinase	MESH:D014284	24385(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|amod|END_ENTITY	Effects of triiodothyronine and retinoic_acid on glucokinase gene expression in neonatal rat hepatocytes .
12746755	0	triiodothyronine	15,31	growth_hormone	96,110	triiodothyronine	growth hormone	MESH:D014284	2688	Chemical	Gene	metabolism|amod|START_ENTITY effects|nmod|metabolism effects|nmod|END_ENTITY	The effects of triiodothyronine on human osteoblast-like cells metabolism and interactions with growth_hormone .
1761276	0	triiodothyronine	95,111	growth_hormone	40,54	triiodothyronine	growth hormone	MESH:D014284	378781(Tax:9031)	Chemical	Gene	thyroxine|acl|START_ENTITY stimulation|nmod|thyroxine stimulation|amod|END_ENTITY	Food intake after hatching inhibits the growth_hormone induced stimulation of the thyroxine to triiodothyronine conversion in the chicken .
1778404	0	triiodothyronine	10,26	growth_hormone	84,98	triiodothyronine	growth hormone	MESH:D014284	2688	Chemical	Gene	supplementation|amod|START_ENTITY supplementation|nmod|END_ENTITY	Effect of triiodothyronine supplementation on thyrotropin-releasing_hormone-induced growth_hormone secretion in sex-linked dwarf and normal chicks .
20647047	0	triiodothyronine	57,73	growth_hormone	11,25	triiodothyronine	growth hormone	MESH:D014284	2688	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of growth_hormone , insulin-like growth factor I , triiodothyronine , thyroxine , and cortisol on gene expression of carbohydrate metabolic enzymes in sea bream hepatocytes .
213445	0	triiodothyronine	91,107	growth_hormone	51,65	triiodothyronine	growth hormone	MESH:D014284	81668(Tax:10116)	Chemical	Gene	Relationship|nmod|START_ENTITY Relationship|nmod|accumulation accumulation|nmod|END_ENTITY	Relationship between the accumulation of pituitary growth_hormone and nuclear occupancy by triiodothyronine in the rat .
2428817	0	triiodothyronine	57,73	growth_hormone	10,24	triiodothyronine	growth hormone	MESH:D014284	2688	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|gene gene|compound|END_ENTITY	The human growth_hormone gene is negatively regulated by triiodothyronine when transfected into rat pituitary_tumor cells .
7208169	0	triiodothyronine	87,103	growth_hormone	16,30	triiodothyronine	growth hormone	MESH:D014284	2688	Chemical	Gene	thyroxine|acl|START_ENTITY conversion|nmod|thyroxine END_ENTITY|nmod|conversion	Action of human growth_hormone -LRB- hGH -RRB- on extrathyroidal conversion of thyroxine -LRB- T4 -RRB- to triiodothyronine -LRB- T3 -RRB- in children with hypopituitarism .
8769362	0	triiodothyronine	133,149	growth_hormone	11,25	triiodothyronine	growth hormone	MESH:D014284	2688	Chemical	Gene	conversion|acl|START_ENTITY significance|nmod|conversion Effects|dep|significance Effects|nmod|END_ENTITY	Effects of growth_hormone on serum lipids and lipoproteins : possible significance of increased peripheral conversion of thyroxine to triiodothyronine .
8674839	0	triiodothyronine	14,30	insulin-like_growth_factor-I	54,82	triiodothyronine	insulin-like growth factor-I	MESH:D014284	24482(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|production production|nmod|END_ENTITY	Estradiol and triiodothyronine increase production of insulin-like_growth_factor-I -LRB- IGF-I -RRB- and insulin-like_growth_factor_binding_protein-3 -LRB- IGFBP-3 -RRB- by GH4C1 rat pituitary_tumor cells .
7883064	0	triiodothyronine	10,26	interleukin-2	64,77	triiodothyronine	interleukin-2	MESH:D014284	373958(Tax:9031)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of triiodothyronine and in vitro growth_hormone on avian interleukin-2 .
16624326	0	triiodothyronine	14,30	leptin	51,57	triiodothyronine	leptin	MESH:D014284	25608(Tax:10116)	Chemical	Gene	Evidence|acl:relcl|START_ENTITY decreases|nsubj|Evidence decreases|dobj|concentration concentration|compound|END_ENTITY	Evidence that triiodothyronine decreases rat serum leptin concentration by down-regulation of leptin gene expression in white adipose tissue .
16624326	0	triiodothyronine	14,30	leptin	94,100	triiodothyronine	leptin	MESH:D014284	25608(Tax:10116)	Chemical	Gene	Evidence|acl:relcl|START_ENTITY decreases|nsubj|Evidence decreases|nmod|down-regulation down-regulation|nmod|expression expression|compound|END_ENTITY	Evidence that triiodothyronine decreases rat serum leptin concentration by down-regulation of leptin gene expression in white adipose tissue .
19846169	0	triiodothyronine	40,56	leptin	67,73	triiodothyronine	leptin	MESH:D014284	25608(Tax:10116)	Chemical	Gene	levels|nmod|START_ENTITY Administration|nmod|levels increases|nsubj|Administration increases|dobj|expression expression|compound|END_ENTITY	Administration of physiologic levels of triiodothyronine increases leptin expression in calorie-restricted obese rats , but does not influence weight_loss .
21557150	0	triiodothyronine	19,35	leptin	51,57	triiodothyronine	leptin	MESH:D014284	25608(Tax:10116)	Chemical	Gene	doses|compound|START_ENTITY diminish|nsubj|doses diminish|dobj|expression expression|compound|END_ENTITY	Supraphysiological triiodothyronine doses diminish leptin and adiponectin gene expression , but do not alter resistin expression in calorie restricted obese rats .
16566928	0	triiodothyronine	58,74	sarcolipin	39,49	triiodothyronine	sarcolipin	MESH:D014284	367086(Tax:10116)	Chemical	Gene	downregulation|nmod|START_ENTITY downregulation|nmod|mRNA mRNA|compound|END_ENTITY	Post-transcriptional downregulation of sarcolipin mRNA by triiodothyronine in the atrial_myocardium .
1306848	0	triiodothyronine	87,103	thyrotropin-releasing_hormone	20,49	triiodothyronine	thyrotropin-releasing hormone	MESH:D014284	7200	Chemical	Gene	Effects|appos|START_ENTITY Effects|nmod|treatment treatment|amod|END_ENTITY	Effects of tartrate thyrotropin-releasing_hormone treatment on serum thyrotropin , free triiodothyronine , free thyroxine and prolactin levels in patients with spinocerebellar_degeneration .
1443425	0	triiodothyronine	43,59	thyrotropin-releasing_hormone	97,126	triiodothyronine	thyrotropin-releasing hormone	MESH:D014284	7200	Chemical	Gene	response|amod|START_ENTITY response|nmod|END_ENTITY	Evidence for normal feedback inhibition of triiodothyronine on the thyrotropin -LRB- TSH -RRB- response to thyrotropin-releasing_hormone -LRB- TRH -RRB- in abstinent male alcoholics .
1713218	0	triiodothyronine	12,28	thyrotropin-releasing_hormone	41,70	triiodothyronine	thyrotropin-releasing hormone	MESH:D014284	7200	Chemical	Gene	response|amod|START_ENTITY free|dobj|response free|advcl|END_ENTITY	Plasma free triiodothyronine response to thyrotropin-releasing_hormone to predict the remission of Graves ' _ disease treated with antithyroid drugs .
1786707	0	triiodothyronine	91,107	thyrotropin-releasing_hormone	20,49	triiodothyronine	thyrotropin-releasing hormone	MESH:D014284	7200	Chemical	Gene	levels|nmod|START_ENTITY administration|nmod|levels administration|amod|END_ENTITY	Effect of exogenous thyrotropin-releasing_hormone -LRB- TRH -RRB- administration on plasma levels of triiodothyronine -LRB- T3 -RRB- , thyroxine -LRB- T4 -RRB- and growth_hormone -LRB- GH -RRB- in chronically catheterized suckling piglets .
2514397	0	triiodothyronine	10,26	thyrotropin-releasing_hormone	34,63	triiodothyronine	thyrotropin-releasing hormone	MESH:D014284	25569(Tax:10116)	Chemical	Gene	lowers|advmod|START_ENTITY lowers|dobj|concentrations concentrations|amod|END_ENTITY	Exogenous triiodothyronine lowers thyrotropin-releasing_hormone concentrations in the specific hypothalamic nucleus -LRB- paraventricular -RRB- involved in thyrotropin regulation and also in posterior nucleus .
415173	0	triiodothyronine	35,51	thyrotropin-releasing_hormone	136,165	triiodothyronine	thyrotropin-releasing hormone	MESH:D014284	7200	Chemical	Gene	START_ENTITY|nmod|trh trh|amod|END_ENTITY	Thyroid-stimulating hormone -LRB- tsh -RRB- , triiodothyronine -LRB- t3 -RRB- and thyroxine -LRB- t4 -RRB- response to intravenous and oral stimulation with synthetic thyrotropin-releasing_hormone -LRB- trh -RRB- in young healthy adults .
6815912	0	triiodothyronine	84,100	thyrotropin-releasing_hormone	21,50	triiodothyronine	thyrotropin-releasing hormone	MESH:D014284	7200	Chemical	Gene	-RSB-|amod|START_ENTITY fasting|nmod|-RSB- -LSB-|advcl|fasting -LSB-|dobj|behavior behavior|nmod|test test|amod|END_ENTITY	-LSB- The behavior of the thyrotropin-releasing_hormone test in fasting with and without triiodothyronine administration -RSB- .
14730205	0	trilinolein	25,36	beta-myosin_heavy_chain	63,86	trilinolein	beta-myosin heavy chain	MESH:C009564	29557(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|amod|END_ENTITY	The inhibitory effect of trilinolein on norepinephrine-induced beta-myosin_heavy_chain promoter activity , reactive oxygen species generation , and extracellular_signal-regulated_kinase phosphorylation in neonatal rat cardiomyocytes .
16184402	0	trilinolein	21,32	c-fos	57,62	trilinolein	c-fos	MESH:C009564	314322(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Inhibitory effect of trilinolein on endothelin-1-induced c-fos gene expression in cultured neonatal rat cardiomyocytes .
21295836	0	trilostane	57,67	3b-hydroxysteroid_dehydrogenase	15,46	trilostane	3b-hydroxysteroid dehydrogenase	MESH:C009954	483146(Tax:9615)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Effects of the 3b-hydroxysteroid_dehydrogenase inhibitor trilostane on luteal progesterone production in the dog .
16300115	0	trilostane	40,50	parathyroid_hormone	54,73	trilostane	parathyroid hormone	MESH:C009954	403986(Tax:9615)	Chemical	Gene	START_ENTITY|nmod|concentrations concentrations|compound|END_ENTITY	Canine hyperadrenocorticism : effects of trilostane on parathyroid_hormone , calcium and phosphate concentrations .
8112388	0	trimebutine	29,40	5-HT3_receptor	70,84	trimebutine	5-HT3 receptor	MESH:D014287	79246(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|antagonist antagonist|amod|END_ENTITY	Comparison of the effects of trimebutine and YM114 -LRB- KAE-393 -RRB- , a novel 5-HT3_receptor antagonist , on stress-induced defecation .
18276837	0	trimesoyl	60,69	haptoglobin	8,19	trimesoyl	haptoglobin	null	3240	Chemical	Gene	uptake|nmod|START_ENTITY END_ENTITY|nmod|uptake	Role of haptoglobin on the uptake of native and beta-chain -LSB- trimesoyl - -LRB- Lys82 -RRB- beta - -LRB- Lys82 -RRB- beta -RSB- cross-linked human hemoglobins in isolated perfused rat livers .
19842999	0	trimester	6,15	PAPP-A	16,22	trimester	PAPP-A	null	5069	Chemical	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	First trimester PAPP-A levels associated with early prediction of pregnancy induced hypertension .
23557166	0	trimester	6,15	PAPP-A	16,22	trimester	PAPP-A	null	5069	Chemical	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	First trimester PAPP-A levels correlate with sFlt-1 levels longitudinally in pregnant women with and without preeclampsia .
16372578	0	trimetazidine	11,24	brain_natriuretic_peptide	89,114	trimetazidine	brain natriuretic peptide	MESH:D014292	4879	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of trimetazidine on lipid peroxidation , antioxidant enzyme activities and plasma brain_natriuretic_peptide levels in patients with chronic_cor_pulmonale .
25864742	0	trimetazidine	10,23	interleukin-6	33,46	trimetazidine	interleukin-6	MESH:D014292	3569	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of trimetazidine on serum interleukin-6 and C-reactive_protein concentrations in patients with stable coronary_artery_disease .
18375259	0	trimetazidine	10,23	xanthine_oxidoreductase	27,50	trimetazidine	xanthine oxidoreductase	MESH:D014292	497811(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effect of trimetazidine on xanthine_oxidoreductase expression in rat kidney with ischemia -- reperfusion injury .
2798310	0	trimethoprim	93,105	FT-IR/ATR	70,79	trimethoprim	FT-IR/ATR	MESH:D014295	545	Chemical	Gene	analysis|nmod|START_ENTITY analysis|compound|END_ENTITY	Quantitative Fourier transform-infrared/attenuated total reflectance -LRB- FT-IR/ATR -RRB- analysis of trimethoprim and sulfamethoxazole in a pharmaceutical formulation using partial least squares .
1952870	0	trimethoprim	68,80	dfrA	90,94	trimethoprim	dfrA	MESH:D014295	2598376(Tax:1280)	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Lack of homology of enterococci which have high-level resistance to trimethoprim with the dfrA gene of Staphylococcus_aureus .
21684339	0	trimethoprim	66,78	dihydrofolate_reductase	118,141	trimethoprim	dihydrofolate reductase	MESH:D014295	1719	Chemical	Gene	START_ENTITY|nmod|mutants mutants|nmod|END_ENTITY	Crystallographic analysis reveals a novel second binding site for trimethoprim in active site double mutants of human dihydrofolate_reductase .
9050157	0	trimethoprim	12,24	dihydrofolate_reductase	34,57	trimethoprim	dihydrofolate reductase	MESH:D014295	1719	Chemical	Gene	START_ENTITY|acl|bound bound|xcomp|END_ENTITY	Dynamics of trimethoprim bound to dihydrofolate_reductase -- a deuterium NMR study .
1137831	0	trimethoprim-sulfamethoxazole	10,39	insulin	49,56	trimethoprim-sulfamethoxazole	insulin	MESH:D015662	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of trimethoprim-sulfamethoxazole on blood insulin and glucose concentrations of diabetics .
16211261	0	trimethoxyphenyl_isoxazolidines	28,59	phospholipase_A2	87,103	trimethoxyphenyl isoxazolidines	phospholipase A2	null	151056	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Synthesis and evaluation of trimethoxyphenyl_isoxazolidines as inhibitors of secretory phospholipase_A2 with anti-inflammatory activity .
23393561	0	trimethylamine	64,78	TAAR5	38,43	trimethylamine	TAAR5	MESH:C023336	9038	Chemical	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	Human trace amine-associated receptor TAAR5 can be activated by trimethylamine .
19501564	0	trimethylamine_N-oxide	86,108	Tropoelastin	0,12	trimethylamine N-oxide	Tropoelastin	MESH:C005855	2006	Chemical	Gene	effect|nmod|START_ENTITY END_ENTITY|dep|effect	Tropoelastin as a thermodynamically unfolded premolten globule protein : The effect of trimethylamine_N-oxide on structure and coacervation .
20621096	0	trimethylguanosine	66,84	Tgs1p	95,100	trimethylguanosine	Tgs1p	null	96764	Chemical	Gene	synthase|amod|START_ENTITY synthase|appos|END_ENTITY	Deletion of Swm2p selectively impairs trimethylation of snRNAs by trimethylguanosine synthase -LRB- Tgs1p -RRB- .
2143105	0	trimethylguanosine	4,22	U1_snRNA	40,48	trimethylguanosine	U1 snRNA	null	394374(Tax:8355)	Chemical	Gene	structure|amod|START_ENTITY structure|nmod|END_ENTITY	The trimethylguanosine cap structure of U1_snRNA is a component of a bipartite nuclear targeting signal .
18572315	0	trimethyltin	110,122	DJ-1	22,26	trimethyltin	DJ-1	MESH:C046488	57320(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|expression expression|nmod|END_ENTITY	Altered expression of DJ-1 in the hippocampal cells following in vivo and in vitro neuronal_damage induced by trimethyltin .
3918766	0	trimethyltin	69,81	Synapsin_I	11,21	trimethyltin	Synapsin I	MESH:C046488	24949(Tax:10116)	Chemical	Gene	use|nmod|START_ENTITY use|nmod|END_ENTITY	The use of Synapsin_I as a biochemical marker for neuronal_damage by trimethyltin .
7893329	0	trimethyltin	11,23	choline_acetyltransferase	33,58	trimethyltin	choline acetyltransferase	MESH:C046488	290567(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effects of trimethyltin -LRB- TMT -RRB- on choline_acetyltransferase activity in the rat hippocampus .
11406319	0	trimethyltin	71,83	enkephalin	31,41	trimethyltin	enkephalin	MESH:C046488	29237(Tax:10116)	Chemical	Gene	intoxication|compound|START_ENTITY END_ENTITY|nmod|intoxication	Temporal change of hippocampal enkephalin and dynorphin mRNA following trimethyltin intoxication in rats : effect of anticonvulsant .
3564070	0	trimethyltin	10,22	ornithine_decarboxylase	26,49	trimethyltin	ornithine decarboxylase	MESH:C046488	18263(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of trimethyltin on ornithine_decarboxylase in various regions of the mouse brain .
8809159	0	trimetoquinol	21,34	beta_2-adrenoceptor	66,85	trimetoquinol	beta 2-adrenoceptor	MESH:D014213	154	Chemical	Gene	ligands|amod|START_ENTITY ligands|amod|END_ENTITY	Iodinated analogs of trimetoquinol as highly potent and selective beta_2-adrenoceptor ligands .
7850779	0	trimetrexate	142,154	dihydrofolate_reductase	22,45	trimetrexate	dihydrofolate reductase	MESH:D016597	1719	Chemical	Gene	lines|amod|START_ENTITY END_ENTITY|nmod|lines	Expression of variant dihydrofolate_reductase with decreased binding affinity to antifolates in MOLT-3 human leukemia cell lines resistant to trimetrexate .
1385949	0	trimetrexate	74,86	thymidylate_synthase	108,128	trimetrexate	thymidylate synthase	MESH:D016597	22171(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY induced|nmod|suppression suppression|nmod|END_ENTITY	Interconversion of tetrahydrofolate cofactors to dihydrofolate induced by trimetrexate after suppression of thymidylate_synthase by fluorodeoxyuridine in L1210 leukemia cells .
11191620	0	trimidox	39,47	c-myc	56,61	trimidox	c-myc	MESH:C074761	4609	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	The ribonucleotide reductase inhibitor trimidox induces c-myc and apoptosis of human ovarian_carcinoma cells .
16503536	0	trimitazidine	11,24	insulin	28,35	trimitazidine	insulin	null	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|resistance resistance|compound|END_ENTITY	-LSB- Effect of trimitazidine on insulin resistance in patients with coronary_heart_disease -RSB- .
23819906	0	trinitrobenzene_sulfonic_acid	85,114	CXCL9	31,36	trinitrobenzene sulfonic acid	CXCL9	MESH:D014302	246759(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|role role|nmod|END_ENTITY	Antifibrotic role of chemokine CXCL9 in experimental chronic pancreatitis induced by trinitrobenzene_sulfonic_acid in rats .
718973	0	trinitrophenylaminolauric_acid	13,43	lipase	92,98	trinitrophenylaminolauric acid	lipase	MESH:C018410	291437(Tax:10116)	Chemical	Gene	Synthesis|nmod|START_ENTITY END_ENTITY|nsubj|Synthesis	Synthesis of trinitrophenylaminolauric_acid and the use of its glyceryl_esters for assaying lipase by a spectrophotometric procedure .
4019488	0	trioleoylglycerol	33,50	Lipoprotein_lipase	0,18	trioleoylglycerol	Lipoprotein lipase	MESH:D014304	280843(Tax:9913)	Chemical	Gene	hydrolysis|nmod|START_ENTITY hydrolysis|amod|END_ENTITY	Lipoprotein_lipase hydrolysis of trioleoylglycerol in a phospholipid interface .
371954	0	triose	29,35	insulin	59,66	triose	insulin	CHEBI:27137	3630	Chemical	Gene	secretion|amod|START_ENTITY secretion|compound|END_ENTITY	On the biochemical nature of triose - and hexose-stimulated insulin secretion .
1720860	0	triose_phosphate	32,48	Tpi	60,63	triose phosphate	Tpi	null	43582(Tax:7227)	Chemical	Gene	isomerase|amod|START_ENTITY gene|amod|isomerase gene|appos|END_ENTITY	Structure and expression of the triose_phosphate isomerase -LRB- Tpi -RRB- gene of Drosophila_melanogaster .
18219118	0	triosephosphate	99,114	TIM	126,129	triosephosphate	TIM	null	7167	Chemical	Gene	isomerase|amod|START_ENTITY isomerase|appos|END_ENTITY	Structural studies show that the A178L mutation in the C-terminal hinge of the catalytic loop-6 of triosephosphate isomerase -LRB- TIM -RRB- induces a closed-like conformation in dimeric and monomeric TIM .
19493007	0	triosephosphate	52,67	tpi	79,82	triosephosphate	tpi	null	21991(Tax:10090)	Chemical	Gene	isomerase|compound|START_ENTITY isomerase|appos|END_ENTITY	Deletion of the gene encoding the glycolytic enzyme triosephosphate isomerase -LRB- tpi -RRB- alters morphology of Salmonella_enterica_serovar_Typhimurium and decreases fitness in mice .
24319992	0	trioxide	66,74	fibroblast_growth_factor-2	27,53	trioxide	fibroblast growth factor-2	null	2247	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|END_ENTITY	The synergistic effects of fibroblast_growth_factor-2 and mineral trioxide aggregate on an osteogenic accelerator in vitro .
17237226	0	tripartite	41,51	LIN7	65,69	tripartite	LIN7	null	8825	Chemical	Gene	complex|amod|START_ENTITY complex|nmod|END_ENTITY	The stardust family protein MPP7 forms a tripartite complex with LIN7 and DLG1 that regulates the stability and localization of DLG1 to cell junctions .
1726722	0	tripartite	49,59	nad5	60,64	tripartite	nad5	null	3800097(Tax:4565)	Chemical	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	A trans-splicing model for the expression of the tripartite nad5 gene in wheat and maize mitochondria .
12697455	0	tripeptide	31,41	CCK-4	25,30	tripeptide	CCK-4	CHEBI:47923	5754	Chemical	Gene	START_ENTITY|nsubj|synthesis synthesis|nmod|END_ENTITY	Enzymatic synthesis of a CCK-4 tripeptide fragment .
2436831	0	tripeptide	29,39	aminopeptidase	40,54	tripeptide	aminopeptidase	CHEBI:47923	10404	Chemical	Gene	START_ENTITY|dobj|activity activity|amod|END_ENTITY	Clinical usefulness of serum tripeptide aminopeptidase activity in diagnosing liver_diseases .
6723039	0	tripeptide	29,39	aminopeptidase	40,54	tripeptide	aminopeptidase	CHEBI:47923	10404	Chemical	Gene	assay|nmod|START_ENTITY END_ENTITY|nsubj|assay	A specific kinetic assay for tripeptide aminopeptidase in serum .
15341490	0	tripeptide	105,115	hPEPT1	128,134	tripeptide	hPEPT1	CHEBI:47923	6564	Chemical	Gene	transporter|amod|START_ENTITY transporter|dep|END_ENTITY	Dipeptidomimetic ketomethylene isosteres as pro-moieties for drug transport via the human intestinal di - / tripeptide transporter hPEPT1 : design , synthesis , stability , and biological investigations .
15727852	0	tripeptide	74,84	hPEPT1	125,131	tripeptide	hPEPT1	CHEBI:47923	6564	Chemical	Gene	restrictions|dep|START_ENTITY restrictions|dep|implications implications|nmod|design design|nmod|prodrugs prodrugs|amod|END_ENTITY	Conformational restrictions in ligand binding to the human intestinal di - / tripeptide transporter : implications for design of hPEPT1 targeted prodrugs .
711378	0	tripeptide_aldehydes	38,58	thrombin	14,22	tripeptide aldehydes	thrombin	null	2147	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of thrombin and trypsin by tripeptide_aldehydes .
22972320	0	tripeptides	31,42	ACE	16,19	tripeptides	ACE	CHEBI:47923	24310(Tax:10116)	Chemical	Gene	Accumulation|amod|START_ENTITY Accumulation|nmod|END_ENTITY	Accumulation of ACE inhibitory tripeptides , Val-Pro-Pro and Ile-Pro-Pro , in vascular endothelial cells .
2983326	0	tripeptides	95,106	angiotensin_I_converting_enzyme	24,55	tripeptides	angiotensin I converting enzyme	CHEBI:47923	1636	Chemical	Gene	START_ENTITY|nsubj|activity activity|nmod|END_ENTITY	Novel activity of human angiotensin_I_converting_enzyme : release of the NH2 - and COOH-terminal tripeptides from the luteinizing_hormone-releasing_hormone .
24650211	0	tripeptides	38,49	dipeptidylpeptidase-IV	53,75	tripeptides	dipeptidylpeptidase-IV	CHEBI:47923	281122(Tax:9913)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|amod|END_ENTITY	Inhibitory effect of collagen-derived tripeptides on dipeptidylpeptidase-IV activity .
1526252	0	triphenylethylene_antiestrogen	84,114	phospholipase_A2	49,65	triphenylethylene antiestrogen	phospholipase A2	null	151056	Chemical	Gene	activities|nmod|START_ENTITY activities|amod|END_ENTITY	In vivo inhibition of basal and estrogen-induced phospholipase_A2 activities by the triphenylethylene_antiestrogen , tamoxifen , in immature quail oviduct .
19173657	0	triphosphate	80,92	DNA_polymerase	112,126	triphosphate	DNA polymerase	MESH:C005692	13897297	Chemical	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Competitive inhibition of uracil DNA glycosylase by a modified nucleotide whose triphosphate is a substrate for DNA_polymerase .
2196171	0	triphosphate	33,45	H-ras	62,67	triphosphate	H-ras	MESH:C005692	3265	Chemical	Gene	conformation|amod|START_ENTITY conformation|nmod|END_ENTITY	Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution : implications for the mechanism of GTP hydrolysis .
1303753	0	triphosphotyrosyl_dodecapeptide	59,90	insulin_receptor	123,139	triphosphotyrosyl dodecapeptide	insulin receptor	null	3643	Chemical	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	NMR analysis of regioselectivity in dephosphorylation of a triphosphotyrosyl_dodecapeptide autophosphorylation site of the insulin_receptor by a catalytic fragment of LAR phosphotyrosine phosphatase .
7622428	0	triprenyl_phenols	63,80	pancreatic_cholesterol_esterase	84,115	triprenyl phenols	pancreatic cholesterol esterase	null	25055(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Isolation , characterization and biological activities of novel triprenyl_phenols as pancreatic_cholesterol_esterase inhibitors produced by Stachybotrys sp .
2416809	0	triprolyl	81,90	myelin_basic_protein	101,121	triprolyl	myelin basic protein	null	4155	Chemical	Gene	region|amod|START_ENTITY region|nmod|END_ENTITY	Identification of an antigenic determinant within the phylogenetically conserved triprolyl region of myelin_basic_protein .
16929507	0	tripterine	11,21	TGF-beta1	44,53	tripterine	TGF-beta1	MESH:C050414	21803(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effects of tripterine on mRNA expression of TGF-beta1 and collagen IV expression in BW_F1 mice .
18652362	0	tripterygium	20,32	IL-18	43,48	tripterygium	IL-18	null	3606	Chemical	Gene	START_ENTITY|nmod|content content|compound|END_ENTITY	-LSB- Sdudy on effect of tripterygium on plasma IL-18 content in patients with lupus_nephritis -RSB- .
25142998	0	tripterygium_wilfordii_polyglucoside	12,48	Activin_A	66,75	tripterygium wilfordii polyglucoside	Activin A	null	29200(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of tripterygium_wilfordii_polyglucoside on expression of Activin_A and influence of transdifferentiation in renal tubulointerstitium of rats with diabetic_nephropathy -RSB- .
16399624	0	triptolide	14,24	CD4	28,31	triptolide	CD4	MESH:C001899	24932(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	The effect of triptolide on CD4 + and CD8 + cells in Peyer 's patch of SD rats with collagen_induced_arthritis .
19921588	0	triptolide	14,24	CD4	28,31	triptolide	CD4	MESH:C001899	24932(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	The effect of triptolide on CD4 + and CD8 + cells in the Peyer 's patch of DA rats with collagen_induced_arthritis .
24910460	0	triptolide	68,78	CYP3A	8,13	triptolide	CYP3A	MESH:C001899	170509(Tax:10116)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of CYP3A in regulating hepatic clearance and hepatotoxicity of triptolide in rat liver microsomes and sandwich-cultured hepatocytes .
22740937	0	triptolide	43,53	P-glycoprotein	14,28	triptolide	P-glycoprotein	MESH:C001899	5243	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|expression expression|amod|END_ENTITY	Modulation of P-glycoprotein expression by triptolide in adriamycin-resistant K562/A02 cells .
23549790	0	triptolide	29,39	TFIIH	54,59	triptolide	TFIIH	MESH:C001899	39202(Tax:7227)	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	The genetic depletion or the triptolide inhibition of TFIIH in p53-deficient cells induces a JNK-dependent cell death in Drosophila .
16961290	0	triptolide	112,122	TNF-alpha	126,135	triptolide	TNF-alpha	MESH:C001899	7124	Chemical	Gene	region|nmod|START_ENTITY polymorphism|nmod|region polymorphism|nmod|production production|amod|END_ENTITY	Relationship between single nucleotide polymorphism in TNF-alpha gene promoter region and inhibitory effects of triptolide on TNF-alpha production in peripheral blood mononuclear cells of healthy humans .
16961290	0	triptolide	112,122	TNF-alpha	55,64	triptolide	TNF-alpha	MESH:C001899	7124	Chemical	Gene	region|nmod|START_ENTITY region|amod|END_ENTITY	Relationship between single nucleotide polymorphism in TNF-alpha gene promoter region and inhibitory effects of triptolide on TNF-alpha production in peripheral blood mononuclear cells of healthy humans .
21278739	0	triptolide	60,70	XPB	0,3	triptolide	XPB	MESH:C001899	2071	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	XPB , a subunit of TFIIH , is a target of the natural product triptolide .
26837169	0	triptolide	12,22	androgen_receptor	44,61	triptolide	androgen receptor	MESH:C001899	367	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of triptolide on the expression of androgen_receptor in human prostate LNCaP cells and its mechanism of action -RSB- .
21805042	0	triptolide	10,20	focal_adhesion_kinase	24,45	triptolide	focal adhesion kinase	MESH:C001899	5747	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of triptolide on focal_adhesion_kinase and survival in MCF-7 breast_cancer cells .
17536259	0	triptolide	12,22	interferon-gamma	44,60	triptolide	interferon-gamma	MESH:C001899	3458	Chemical	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	-LSB- Effects of triptolide on the production of interferon-gamma in human peripheral blood mononuclear cell and phosphorylation of signal_transducer_and_activator_of_transcription-1 and production of interleukin-8 -RSB- .
23796028	0	triptolide	48,58	interleukin-13	14,28	triptolide	interleukin-13	MESH:C001899	3596	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|expression expression|amod|END_ENTITY	Inhibition of interleukin-13 gene expression by triptolide in activated T lymphocytes .
17937863	0	triptolide	11,21	matrix_metalloproteinases_2_and_9	43,76	triptolide	matrix metalloproteinases 2 and 9	MESH:C001899	81686(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of triptolide on the expression of matrix_metalloproteinases_2_and_9 in lungs of experimental pulmonary_hypertension -RSB- .
15957833	0	triptolide	11,21	monocyte_chemottractant_protein-1	33,66	triptolide	monocyte chemottractant protein-1	MESH:C001899	6347	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Effect of triptolide on urinary monocyte_chemottractant_protein-1 in patients with diabetic_nephropathy -RSB- .
11753684	9	triptolide	1389,1399	p53	1474,1477	triptolide	p53	MESH:C001899	7157	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|nmod|END_ENTITY	We showed that triptolide also inhibited cell growth and induced apoptosis in MKN-45 with wild-type p53 , whereas it had no significant growth-inhibition and apoptosis induction effects on the MKN-28 and SGC-7901 cells with mutant p53 .
16961289	0	triptolide	10,20	receptor_activator_of_nuclear_factor-kappaB_ligand	38,88	triptolide	receptor activator of nuclear factor-kappaB ligand	MESH:C001899	117516(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of triptolide on expression of receptor_activator_of_nuclear_factor-kappaB_ligand in rat adjuvant_induced_arthritis .
22498763	0	triptolide	11,21	synaptophysin	29,42	triptolide	synaptophysin	MESH:C001899	24804(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of triptolide on the synaptophysin expression of hippocampal neurons in the AD cellular model .
25945607	0	triptolide	10,20	thrombospondin-1_and_transforming_growth_factor-b1	38,88	triptolide	thrombospondin-1 and transforming growth factor-b1	MESH:C001899	7057;7040	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of triptolide on expression of thrombospondin-1_and_transforming_growth_factor-b1 in renal tubular cells .
25945607	0	triptolide	10,20	thrombospondin-1_and_transforming_growth_factor-b1	38,88	triptolide	thrombospondin-1 and transforming growth factor-b1	MESH:C001899	7057;7040	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of triptolide on expression of thrombospondin-1_and_transforming_growth_factor-b1 in renal tubular cells .
11988867	0	triptolide	78,88	vascular_endothelial_growth_factor	14,48	triptolide	vascular endothelial growth factor	MESH:C001899	7422	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|expression expression|compound|END_ENTITY	Inhibition of vascular_endothelial_growth_factor expression and production by triptolide .
10685535	0	triptorelin	218,229	LH-RH	203,208	triptorelin	LH-RH	MESH:D017329	2796	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	Prospective , randomized , controlled study of in vitro fertilization-embryo transfer with a single dose of a luteinizing_hormone-releasing_hormone -LRB- LH-RH -RRB- antagonist -LRB- cetrorelix -RRB- or a depot formula of an LH-RH agonist -LRB- triptorelin -RRB- .
10525370	0	triptorelin	34,45	LHRH	65,69	triptorelin	LHRH	MESH:D017329	2796	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	A multicenter phase II study with triptorelin -LRB- sustained-release LHRH agonist -RRB- in advanced or recurrent endometrial_carcinoma : a French anticancer federation study .
11593037	0	triptorelin	122,133	LHRH	170,174	triptorelin	LHRH	MESH:D017329	25194(Tax:10116)	Chemical	Gene	agonist|dobj|START_ENTITY agonist|nmod|expression expression|nmod|receptors receptors|compound|END_ENTITY	Comparison of mechanisms of action of luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- antagonist cetrorelix and LHRH agonist triptorelin on the gene expression of pituitary LHRH receptors in rats .
11593037	0	triptorelin	122,133	LHRH	77,81	triptorelin	LHRH	MESH:D017329	25194(Tax:10116)	Chemical	Gene	agonist|dobj|START_ENTITY agonist|nsubj|Comparison Comparison|nmod|mechanisms mechanisms|nmod|action action|nmod|cetrorelix cetrorelix|appos|END_ENTITY	Comparison of mechanisms of action of luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- antagonist cetrorelix and LHRH agonist triptorelin on the gene expression of pituitary LHRH receptors in rats .
8029088	0	triptorelin	123,134	LHRH	79,83	triptorelin	LHRH	MESH:D017329	2796	Chemical	Gene	antagonists|appos|START_ENTITY antagonists|compound|END_ENTITY	-LSB- Short-term comparison of the treatment of precocious puberty with 2 different LHRH antagonists -LRB- buserelin and long-acting triptorelin -RRB- .
10901441	0	triptorelin	11,22	PC3	100,103	triptorelin	PC3	MESH:D017329	57332	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of triptorelin , a gonadotropin-releasing_hormone agonist , on the human prostatic cell lines PC3 and LNCaP .
10926802	0	triptorelin	46,57	c-fos	104,109	triptorelin	c-fos	MESH:D017329	2353	Chemical	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|expression expression|amod|END_ENTITY	Luteinizing_hormone-releasing_hormone agonist triptorelin and antagonist cetrorelix inhibit EGF-induced c-fos expression in human gynecological cancers .
10901441	0	triptorelin	11,22	gonadotropin-releasing_hormone	26,56	triptorelin	gonadotropin-releasing hormone	MESH:D017329	2796	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Effects of triptorelin , a gonadotropin-releasing_hormone agonist , on the human prostatic cell lines PC3 and LNCaP .
8428922	0	trisaccharide	2,15	N-acetylglucosaminyltransferase_V	36,69	trisaccharide	N-acetylglucosaminyltransferase V	CHEBI:27150	4249	Chemical	Gene	analog|amod|START_ENTITY analog|nmod|END_ENTITY	A trisaccharide acceptor analog for N-acetylglucosaminyltransferase_V which binds to the enzyme but sterically precludes the transfer reaction .
25452580	0	trisodium_pyrophosphate	23,46	tas1r3	63,69	trisodium pyrophosphate	tas1r3	MESH:C003319	83771(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|acl|lacking lacking|dobj|END_ENTITY	Heightened avidity for trisodium_pyrophosphate in mice lacking tas1r3 .
20221403	0	tristetraprolin	25,40	CIN85	105,110	tristetraprolin	CIN85	null	30011	Chemical	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of human tristetraprolin in response to its interaction with the Cbl interacting protein CIN85 .
22426177	0	tristetraprolin	129,144	HuR	0,3	tristetraprolin	HuR	null	1994	Chemical	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	HuR post-transcriptionally regulates TNF-a-induced IL-6 expression in human pulmonary microvascular endothelial cells mainly via tristetraprolin .
22268119	0	tristetraprolin	84,99	ICAM-1	64,70	tristetraprolin	ICAM-1	null	3383	Chemical	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	MK2 posttranscriptionally regulates TNF-a-induced expression of ICAM-1 and IL-8 via tristetraprolin in human pulmonary microvascular endothelial cells .
11546803	0	tristetraprolin	103,118	p38	126,129	tristetraprolin	p38	null	1432	Chemical	Gene	START_ENTITY|nmod|pathway pathway|amod|END_ENTITY	Decreased sensitivity of tristetraprolin-deficient cells to p38 inhibitors suggests the involvement of tristetraprolin in the p38 signaling pathway .
19131247	0	trisubstituted_cyclohexanes	13,40	CCR2	76,80	trisubstituted cyclohexanes	CCR2	null	729230	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Discovery of trisubstituted_cyclohexanes as potent CC_chemokine_receptor_2 -LRB- CCR2 -RRB- antagonists .
19386595	0	triterpene_30-oxo-calenduladiol	16,47	CCR5	53,57	triterpene 30-oxo-calenduladiol	CCR5	null	1234	Chemical	Gene	antagonist|nsubj|START_ENTITY antagonist|compound|END_ENTITY	The lupane-type triterpene_30-oxo-calenduladiol is a CCR5 antagonist with anti-HIV-1 and anti-chemotactic activities .
16580200	0	triterpenes	55,66	Protein_tyrosine_phosphatase_1B	0,31	triterpenes	Protein tyrosine phosphatase 1B	MESH:D014315	5770	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Protein_tyrosine_phosphatase_1B inhibitory activity of triterpenes isolated from Astilbe koreana .
24096553	0	triterpenes	81,92	Protein_tyrosine_phosphatase_1B	0,31	triterpenes	Protein tyrosine phosphatase 1B	MESH:D014315	5770	Chemical	Gene	activities|nmod|START_ENTITY activities|amod|END_ENTITY	Protein_tyrosine_phosphatase_1B inhibitory activities of ursane - and lupane-type triterpenes from Sorbus pohuashanensis .
24837432	0	triterpenoid	10,22	15-PGDH	31,38	triterpenoid	15-PGDH	CHEBI:36615	15446(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nummod|END_ENTITY	Synthetic triterpenoid induces 15-PGDH expression and suppresses inflammation-driven colon carcinogenesis .
24715223	0	triterpenoid	14,26	STAT3	46,51	triterpenoid	STAT3	CHEBI:36615	20848(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	The synthetic triterpenoid -LRB- CDDO-Im -RRB- inhibits STAT3 , as well as IL-17 , and improves DSS-induced colitis in mice .
24738052	0	triterpenoid	55,67	STAT3	149,154	triterpenoid	STAT3	CHEBI:36615	6774	Chemical	Gene	compounds|amod|START_ENTITY effects|nmod|compounds inducing|dobj|effects inducing|dep|blocking blocking|dobj|functions functions|nmod|macrophages macrophages|nmod|inhibition inhibition|compound|END_ENTITY	A novel strategy for inducing the antitumor effects of triterpenoid compounds : blocking the protumoral functions of tumor-associated macrophages via STAT3 inhibition .
22132201	0	triterpenoid	21,33	glucocorticoid_receptor	55,78	triterpenoid	glucocorticoid receptor	CHEBI:36615	2908	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	The anticancer plant triterpenoid , avicin_D , regulates glucocorticoid_receptor signaling : implications for cellular metabolism .
21353543	0	triterpenoid_glycoside	18,40	TNF-a	129,134	triterpenoid glycoside	TNF-a	null	21926(Tax:10090)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|production production|nmod|END_ENTITY	A new ursane-type triterpenoid_glycoside from Centella asiatica leaves modulates the production of nitric_oxide and secretion of TNF-a in activated RAW 264.7 cells .
18058803	0	triterpenoid_methyl_25-hydroxy-3-oxoolean-12-en-28-oate	16,71	JNK	98,101	triterpenoid methyl 25-hydroxy-3-oxoolean-12-en-28-oate	JNK	null	5599	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Novel synthetic triterpenoid_methyl_25-hydroxy-3-oxoolean-12-en-28-oate induces apoptosis through JNK and p38 MAPK pathways in human breast_adenocarcinoma MCF-7 cells .
21237302	0	triterpenoid_saponin	18,38	iNOS	89,93	triterpenoid saponin	iNOS	CHEBI:61778	18126(Tax:10090)	Chemical	Gene	inhibited|nsubj|START_ENTITY inhibited|dobj|END_ENTITY	Tormentic_acid , a triterpenoid_saponin , isolated from Rosa rugosa , inhibited LPS-induced iNOS , COX-2 , and TNF-a expression through inactivation of the nuclear factor-kb pathway in RAW 264.7 macrophages .
16462054	0	triterpenoids	38,51	5alpha-reductase	0,16	triterpenoids	5alpha-reductase	CHEBI:36615	6715	Chemical	Gene	effect|nmod|START_ENTITY effect|amod|END_ENTITY	5alpha-reductase inhibitory effect of triterpenoids isolated from Ganoderma lucidum .
19846941	0	triterpenoids	31,44	ABCB1	89,94	triterpenoids	ABCB1	CHEBI:36615	18669(Tax:10090)	Chemical	Gene	Evaluation|nmod|START_ENTITY Evaluation|appos|END_ENTITY	Evaluation of cucurbitane-type triterpenoids from Momordica balsamina on P-glycoprotein -LRB- ABCB1 -RRB- by flow cytometry and real-time fluorometry .
12186419	0	triterpenoids	25,38	ICAM-1	82,88	triterpenoids	ICAM-1	CHEBI:36615	3383	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of oleanane-type triterpenoids from fabaceous plants on the expression of ICAM-1 .
15798995	0	triterpenoids	10,23	PDE4	105,109	triterpenoids	PDE4	CHEBI:36615	5141	Chemical	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	Bioactive triterpenoids from Vochysia pacifica interact with cyclic_nucleotide_phosphodiesterase isozyme PDE4 .
26307417	0	triterpenoids	41,54	neuraminidase	14,27	triterpenoids	neuraminidase	CHEBI:36615	4758	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of neuraminidase by Ganoderma triterpenoids and implications for neuraminidase inhibitor design .
26307417	0	triterpenoids	41,54	neuraminidase	76,89	triterpenoids	neuraminidase	CHEBI:36615	4758	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|design design|amod|END_ENTITY	Inhibition of neuraminidase by Ganoderma triterpenoids and implications for neuraminidase inhibitor design .
24841003	0	triterpenoids	4,17	protein_tyrosine_phosphatase_1B	23,54	triterpenoids	protein tyrosine phosphatase 1B	CHEBI:36615	5770	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|amod|END_ENTITY	New triterpenoids with protein_tyrosine_phosphatase_1B inhibition from Cedrela odorata .
3668523	0	trithiomolybdate	47,63	albumin	91,98	trithiomolybdate	albumin	MESH:C034540	280717(Tax:9913)	Chemical	Gene	binding|nmod|START_ENTITY END_ENTITY|amod|binding	Spectral and kinetic studies on the binding of trithiomolybdate to bovine and canine serum albumin in vitro : the interaction with copper .
15914356	0	trithorax	11,20	MLL	33,36	trithorax	MLL	null	4297	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Roles of a trithorax group gene , MLL , in hematopoiesis .
18713858	0	trithorax	42,51	Rad21	31,36	trithorax	Rad21	null	3354896(Tax:7227)	Chemical	Gene	protein|amod|START_ENTITY protein|nsubj|END_ENTITY	The Drosophila cohesin subunit Rad21 is a trithorax group -LRB- trxG -RRB- protein .
26551587	0	tritium	50,57	milk	18,22	tritium	milk	CHEBI:29304	100532204	Chemical	Gene	vicinity|nmod|START_ENTITY END_ENTITY|nmod|vicinity	Tritium levels in milk in the vicinity of chronic tritium releases .
8440133	0	tritium	71,78	thyroid_peroxidase	38,56	tritium	thyroid peroxidase	CHEBI:29304	7173	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Regional sublocalization of the human thyroid_peroxidase gene -LRB- TPO -RRB- by tritium and fluorescence in situ hybridization to chromosome 2p25 -- > p24 .
14693409	0	troglitazone	47,59	C-reactive_protein	18,36	troglitazone	C-reactive protein	MESH:C057693	1401	Chemical	Gene	levels|nmod|START_ENTITY levels|amod|END_ENTITY	Decrease in serum C-reactive_protein levels by troglitazone is associated with pretreatment insulin resistance , but independent of its effect on glycemia , in type 2 diabetic subjects .
17056281	0	troglitazone	137,149	Connective_tissue_growth_factor	0,31	troglitazone	Connective tissue growth factor	MESH:C057693	1490	Chemical	Gene	effects|nmod|START_ENTITY secretion|dep|effects secretion|compound|END_ENTITY	Connective_tissue_growth_factor and fibronectin secretion in renal tubular epithelial cells induced by TGF-beta1 : suppressive effects of troglitazone .
21229889	0	troglitazone	13,25	ENA-78	99,105	troglitazone	ENA-78	MESH:C057693	6374	Chemical	Gene	Influence|acl|START_ENTITY Influence|nmod|END_ENTITY	Influence of troglitazone , sodium_butyrate , 5-aminosalicylic_acid and BAY_11-7082 on the chemokine ENA-78 / CXCL5 secretion in the intestinal subepithelial myofibroblasts .
10814527	0	troglitazone	20,32	Insulin	0,7	troglitazone	Insulin	MESH:C057693	3630	Chemical	Gene	sensitizer|appos|START_ENTITY sensitizer|compound|END_ENTITY	Insulin sensitizer , troglitazone , directly inhibits aromatase activity in human ovarian granulosa cells .
10802155	0	troglitazone	21,33	MCP-1	105,110	troglitazone	MCP-1	MESH:C057693	6347	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Inhibitory effect of troglitazone on TNF-alpha-induced expression of monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- in human endothelial cells .
10678274	0	troglitazone	233,245	PPAR	211,215	troglitazone	PPAR	MESH:C057693	5465	Chemical	Gene	gamma|dep|START_ENTITY _|dep|gamma _|dep|inhibition inhibition|nmod|peroxisome_proliferator-activated_receptor peroxisome_proliferator-activated_receptor|appos|END_ENTITY	Peroxisome_proliferator-activated_receptor _ -LRB- PPAR -RRB- - gamma expression in human vascular smooth muscle cells : inhibition of growth , migration , and c-fos expression by the peroxisome_proliferator-activated_receptor -LRB- PPAR -RRB- - gamma activator troglitazone .
12846423	0	troglitazone	74,86	PPAR	55,59	troglitazone	PPAR	MESH:C057693	5465	Chemical	Gene	ligand|dobj|START_ENTITY ligand|nsubj|Use Use|nmod|gamma gamma|appos|END_ENTITY	Use of the peroxisome_proliferator-activated_receptor -LRB- PPAR -RRB- gamma ligand troglitazone as treatment for refractory_breast_cancer : a phase II study .
9832300	0	troglitazone	20,32	PPAR-gamma	36,46	troglitazone	PPAR-gamma	MESH:C057693	5468	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Pharmacokinetics of troglitazone , a PPAR-gamma agonist , in patients with hepatic_insufficiency .
12044893	0	troglitazone	20,32	PPAR_gamma	0,10	troglitazone	PPAR gamma	MESH:C057693	5468	Chemical	Gene	ligands|amod|START_ENTITY ligands|compound|END_ENTITY	PPAR_gamma ligands , troglitazone and pioglitazone , up-regulate expression of HMG-CoA_synthase and HMG-CoA_reductase gene in THP-1 macrophages .
12416897	0	troglitazone	20,32	PPARgamma	54,63	troglitazone	PPARgamma	MESH:C057693	5468	Chemical	Gene	study|nmod|START_ENTITY study|appos|activator activator|nmod|receptor receptor|compound|END_ENTITY	A phase II study of troglitazone , an activator of the PPARgamma receptor , in patients with chemotherapy-resistant metastatic colorectal_cancer .
15535974	0	troglitazone	97,109	PPARgamma	79,88	troglitazone	PPARgamma	MESH:C057693	5468	Chemical	Gene	ligand|appos|START_ENTITY ligand|compound|END_ENTITY	Fucoxanthin induces apoptosis and enhances the antiproliferative effect of the PPARgamma ligand , troglitazone , on colon_cancer cells .
16945329	0	troglitazone	59,71	PPARgamma	93,102	troglitazone	PPARgamma	MESH:C057693	5468	Chemical	Gene	START_ENTITY|nmod|up-regulation up-regulation|nmod|END_ENTITY	Phorbol_ester potentiates the growth inhibitory effects of troglitazone via up-regulation of PPARgamma in A549 cells .
18356692	0	troglitazone	15,27	PPARgamma	38,47	troglitazone	PPARgamma	MESH:C057693	5468	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Phosphorylated troglitazone activates PPARgamma and inhibits vascular smooth muscle cell proliferation and proteoglycan synthesis .
18474441	0	troglitazone	80,92	PPARgamma	156,165	troglitazone	PPARgamma	MESH:C057693	5468	Chemical	Gene	Induction|nmod|START_ENTITY ligand|advcl|Induction ligand|nsubj|peroxisome_proliferator-activated_receptor_gamma peroxisome_proliferator-activated_receptor_gamma|appos|END_ENTITY	Induction of G1 phase arrest and apoptosis in MDA-MB-231 breast_cancer cells by troglitazone , a synthetic peroxisome_proliferator-activated_receptor_gamma -LRB- PPARgamma -RRB- ligand .
18477501	0	troglitazone	89,101	PPARgamma	46,55	troglitazone	PPARgamma	MESH:C057693	5468	Chemical	Gene	effects|nmod|START_ENTITY effects|compound|END_ENTITY	Loss of XIAP sensitizes colon_cancer cells to PPARgamma independent antitumor effects of troglitazone and 15-PGJ2 .
19252820	1	troglitazone	343,355	PPARgamma	205,214	troglitazone	PPARgamma	MESH:C057693	5468	Chemical	Gene	agonist|appos|START_ENTITY treated|nmod|agonist lines|acl:relcl|treated utilized|dobj|lines utilized|advcl|analyze analyze|dobj|effects effects|nmod|activation activation|appos|END_ENTITY	In order to analyze the effects of peroxisome_proliferator-activated_receptor-gamma -LRB- PPARgamma -RRB- activation on renal_cell_carcinomas we utilized several cell lines that were treated with the high affinity PPARgamma agonist , troglitazone .
20556576	0	troglitazone	105,117	PPARgamma	81,90	troglitazone	PPARgamma	MESH:C057693	5468	Chemical	Gene	activation|nmod|START_ENTITY Reversal|acl|activation Reversal|nmod|END_ENTITY	Reversal of P-glycoprotein-mediated multidrug resistance in SGC7901/VCR cells by PPARgamma activation by troglitazone .
15100737	0	troglitazone	55,67	Peroxisome_proliferator-actived_receptor-gamma	1,47	troglitazone	Peroxisome proliferator-actived receptor-gamma	MESH:C057693	5468	Chemical	Gene	induces|nsubj|START_ENTITY ligand|ccomp|induces ligand|nsubj|END_ENTITY	-LSB- Peroxisome_proliferator-actived_receptor-gamma ligand troglitazone induces apoptosis in renal_cell_carcinoma -RSB- .
16303758	0	troglitazone	52,64	Proline_oxidase	0,15	troglitazone	Proline oxidase	MESH:C057693	5625	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Proline_oxidase , a proapoptotic gene , is induced by troglitazone : evidence for both peroxisome_proliferator-activated_receptor_gamma-dependent and - independent mechanisms .
10617087	0	troglitazone	21,33	insulin	69,76	troglitazone	insulin	MESH:C057693	3630	Chemical	Gene	synthesis|nmod|START_ENTITY synthesis|dep|drug drug|acl|treating treating|dobj|resistance resistance|compound|END_ENTITY	A short synthesis of troglitazone : an antidiabetic drug for treating insulin resistance .
10815754	0	troglitazone	11,23	insulin	27,34	troglitazone	insulin	MESH:C057693	3630	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|sensitivity sensitivity|compound|END_ENTITY	Effects of troglitazone on insulin sensitivity in HIV-infected patients with protease inhibitor-associated diabetes_mellitus .
10917034	0	troglitazone	67,79	insulin	103,110	troglitazone	insulin	MESH:C057693	3630	Chemical	Gene	responding|xcomp|START_ENTITY case|acl|responding -LSB-|dobj|case mechanism|dep|-LSB- mechanism|nmod|resistance resistance|compound|END_ENTITY	-LSB- A 75-year-old type_2_diabetes_mellitus case responding strikingly troglitazone : possible mechanism of insulin resistance induced by insulin antibody -RSB- .
10917034	0	troglitazone	67,79	insulin	133,140	troglitazone	insulin	MESH:C057693	3630	Chemical	Gene	responding|xcomp|START_ENTITY case|acl|responding -LSB-|dobj|case mechanism|dep|-LSB- mechanism|acl|induced induced|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- A 75-year-old type_2_diabetes_mellitus case responding strikingly troglitazone : possible mechanism of insulin resistance induced by insulin antibody -RSB- .
11368854	0	troglitazone	20,32	insulin	59,66	troglitazone	insulin	MESH:C057693	3630	Chemical	Gene	contraction|compound|START_ENTITY effects|nmod|contraction effects|nmod|END_ENTITY	Combined effects of troglitazone and muscle contraction on insulin sensitization in Balb-c mouse muscle .
12728539	0	troglitazone	55,67	insulin	101,108	troglitazone	insulin	MESH:C057693	3630	Chemical	Gene	START_ENTITY|nmod|individuals individuals|nmod|resistance resistance|compound|END_ENTITY	Long-term cardiovascular effects of insulin sensitizer troglitazone on non-diabetic individuals with insulin resistance : double blind , prospective randomized study .
14506629	0	troglitazone	37,49	insulin	17,24	troglitazone	insulin	MESH:C057693	3630	Chemical	Gene	START_ENTITY|nsubj|impact impact|nmod|sensitizer sensitizer|compound|END_ENTITY	The impact of an insulin sensitizer , troglitazone , on glucose metabolism in African Americans at risk for type_2_diabetes_mellitus : a placebo-controlled , 24-month randomized study .
15311105	0	troglitazone	37,49	insulin	15,22	troglitazone	insulin	MESH:C057693	3630	Chemical	Gene	ameliorates|amod|START_ENTITY resistance|nmod|ameliorates resistance|compound|END_ENTITY	Improvement of insulin resistance by troglitazone ameliorates cardiac_sympathetic_nervous_dysfunction in patients with essential hypertension .
16093575	0	troglitazone	29,41	insulin	98,105	troglitazone	insulin	MESH:C057693	3630	Chemical	Gene	effects|nmod|START_ENTITY subjects|nsubj|effects subjects|dobj|independent independent|nmod|changes changes|nmod|sensitivity sensitivity|compound|END_ENTITY	Anti-inflammatory effects of troglitazone in nondiabetic obese subjects independent of changes in insulin sensitivity .
9186311	0	troglitazone	16,28	insulin	81,88	troglitazone	insulin	MESH:C057693	3630	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|metabolism metabolism|nmod|absence absence|nmod|END_ENTITY	Acute effect of troglitazone on glucose metabolism in the absence or presence of insulin in perfused rat hindlimb .
9284856	0	troglitazone	11,23	insulin	27,34	troglitazone	insulin	MESH:C057693	3630	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|action action|compound|END_ENTITY	Effects of troglitazone on insulin action and cardiovascular risk factors in patients with non-insulin-dependent_diabetes .
9392315	0	troglitazone	10,22	insulin	32,39	troglitazone	insulin	MESH:C057693	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|compound|END_ENTITY	Effect of troglitazone on blood insulin levels after pancreas_transplantation_with_systemic_venous_drainage in rats .
9392315	2	troglitazone	348,360	insulin	364,371	troglitazone	insulin	MESH:C057693	3630	Chemical	Gene	effect|nmod|START_ENTITY examine|dobj|effect examine|nmod|regulation regulation|compound|END_ENTITY	To examine the effect of troglitazone on insulin regulation after pancreas_transplantation_with_systemic_venous_drainage , we measured peripheral glucose and insulin levels and performed an intravenous glucose tolerance test .
9988406	0	troglitazone	10,22	insulin	76,83	troglitazone	insulin	MESH:C057693	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|women women|nmod|polycystic_ovary_syndrome polycystic_ovary_syndrome|compound|END_ENTITY	Effect of troglitazone on endocrine and ovulatory performance in women with insulin resistance-related polycystic_ovary_syndrome .
11092516	0	troglitazone	32,44	leptin	14,20	troglitazone	leptin	MESH:C057693	3952	Chemical	Gene	release|nmod|START_ENTITY release|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of leptin release by troglitazone in human adipose tissue .
11483231	0	troglitazone	71,83	leptin	6,12	troglitazone	leptin	MESH:C057693	3952	Chemical	Gene	efficacy|nmod|START_ENTITY predict|dobj|efficacy indicator|acl|predict Serum|nmod|indicator Serum|dobj|level level|compound|END_ENTITY	Serum leptin level as an indicator to predict the clinical efficacy of troglitazone in patients with type_2_diabetes_mellitus .
8772734	0	troglitazone	10,22	leptin	26,32	troglitazone	leptin	MESH:C057693	3952	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|production production|compound|END_ENTITY	Effect of troglitazone on leptin production .
16136964	0	troglitazone	35,47	mPges	15,20	troglitazone	mPges	MESH:C057693	64292(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	-LSB- Depression of mPges expression by troglitazone in human renal glomerulus induced by high glucose and LPS -RSB- .
10690939	0	troglitazone	21,33	monocyte_chemoattractant_protein-1	87,121	troglitazone	monocyte chemoattractant protein-1	MESH:C057693	6347	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Inhibitory effect of troglitazone on tumor_necrosis_factor_alpha-induced expression of monocyte_chemoattractant_protein-1 in human mesangial cells .
10802155	0	troglitazone	21,33	monocyte_chemoattractant_protein-1	69,103	troglitazone	monocyte chemoattractant protein-1	MESH:C057693	6347	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Inhibitory effect of troglitazone on TNF-alpha-induced expression of monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- in human endothelial cells .
16981146	0	troglitazone	23,35	musclin	44,51	troglitazone	musclin	MESH:C057693	344901	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	The PPAR_gamma agonist troglitazone induces musclin mRNA expression in human myotubes .
10097144	0	troglitazone	104,116	peroxisome_proliferator-activated_receptor-gamma	48,96	troglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C057693	5468	Chemical	Gene	ligand|dobj|START_ENTITY ligand|nsubj|Induction Induction|nmod|differentiation differentiation|nmod|END_ENTITY	Induction of solid_tumor differentiation by the peroxisome_proliferator-activated_receptor-gamma ligand troglitazone in patients with liposarcoma .
10871190	0	troglitazone	79,91	peroxisome_proliferator-activated_receptor-gamma	27,75	troglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C057693	5468	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Differential activation of peroxisome_proliferator-activated_receptor-gamma by troglitazone and rosiglitazone .
11752099	0	troglitazone	18,30	peroxisome_proliferator-activated_receptor-gamma	46,94	troglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C057693	19016(Tax:10090)	Chemical	Gene	ability|nmod|START_ENTITY ability|nmod|expression expression|amod|END_ENTITY	Unique ability of troglitazone to up-regulate peroxisome_proliferator-activated_receptor-gamma expression in hepatocytes .
12680223	0	troglitazone	36,48	peroxisome_proliferator-activated_receptor-gamma	57,105	troglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C057693	5468	Chemical	Gene	apoptosis|nmod|START_ENTITY mechanism|nmod|apoptosis mechanism|nmod|END_ENTITY	Induction mechanism of apoptosis by troglitazone through peroxisome_proliferator-activated_receptor-gamma in gastric_carcinoma cells .
16319070	0	troglitazone	60,72	peroxisome_proliferator-activated_receptor-gamma	2,50	troglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C057693	5468	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	A peroxisome_proliferator-activated_receptor-gamma agonist , troglitazone , facilitates caspase-8_and _ -9 activities by increasing the enzymatic activity of protein-tyrosine_phosphatase-1B on human glioma cells .
16883598	0	troglitazone	21,33	peroxisome_proliferator-activated_receptor-gamma	42,90	troglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C057693	5468	Chemical	Gene	induced|nmod|START_ENTITY Apoptosis|acl|induced END_ENTITY|nsubj|Apoptosis	Apoptosis induced by troglitazone is both peroxisome_proliferator-activated_receptor-gamma - and ERK-dependent in human non-small lung_cancer cells .
16892143	0	troglitazone	68,80	peroxisome_proliferator-activated_receptor-gamma	12,60	troglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C057693	5468	Chemical	Gene	ligand|dobj|START_ENTITY ligand|nsubj|Effects Effects|nmod|END_ENTITY	-LSB- Effects of peroxisome_proliferator-activated_receptor-gamma ligand troglitazone on colon_cancer cell growth -RSB- .
18599600	0	troglitazone	166,178	peroxisome_proliferator-activated_receptor-gamma	109,157	troglitazone	peroxisome proliferator-activated receptor-gamma	MESH:C057693	19016(Tax:10090)	Chemical	Gene	agonist|amod|START_ENTITY agonist|amod|END_ENTITY	Keratinocyte-derived vascular_endothelial_growth_factor biosynthesis represents a pleiotropic side effect of peroxisome_proliferator-activated_receptor-gamma agonist troglitazone but not rosiglitazone and involves activation of p38 mitogen-activated protein kinase : implications for diabetes-impaired skin repair .
10871202	0	troglitazone	11,23	plasminogen_activator_inhibitor_1	51,84	troglitazone	plasminogen activator inhibitor 1	MESH:C057693	5054	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of troglitazone on blood concentrations of plasminogen_activator_inhibitor_1 in patients with type 2 diabetes and in lean and obese normal subjects .
10807946	0	troglitazone	19,31	tumor_necrosis_factor-alpha	43,70	troglitazone	tumor necrosis factor-alpha	MESH:C057693	21926(Tax:10090)	Chemical	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|nmod|END_ENTITY	Down-regulation by troglitazone of hepatic tumor_necrosis_factor-alpha and interleukin-6 mRNA expression in a murine model of non-insulin-dependent_diabetes .
11095572	0	troleandomycin	123,137	CYP3A	36,41	troleandomycin	CYP3A	MESH:D014217	1576	Chemical	Gene	response|nmod|START_ENTITY differences|nmod|response Effects|dep|differences Effects|nmod|antibiotics antibiotics|nmod|expression expression|nummod|END_ENTITY	Effects of macrolide antibiotics on CYP3A expression in human and rat hepatocytes : interspecies differences in response to troleandomycin .
9278210	0	troleandomycin	10,24	CYP3A	87,92	troleandomycin	CYP3A	MESH:D014217	1576	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|role role|nmod|END_ENTITY	Effect of troleandomycin on the pharmacokinetics of imipramine in Chinese : the role of CYP3A .
17067664	0	tropisetron	48,59	5-HT3_receptor	21,35	tropisetron	5-HT3 receptor	MESH:C045504	79246(Tax:10116)	Chemical	Gene	treatment|appos|START_ENTITY treatment|nmod|antagonist antagonist|amod|END_ENTITY	Acute treatment with 5-HT3_receptor antagonist , tropisetron , reduces immobility in intact female rats exposed to the forced swim test .
9014026	0	tropisetron	27,38	5-HT3_receptor	0,14	tropisetron	5-HT3 receptor	MESH:C045504	79246(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|amod|END_ENTITY	5-HT3_receptor antagonist , tropisetron , does not influence ethanol-induced conditioned taste aversion and conditioned place aversion .
3789890	0	tropolone	22,31	COMT	54,58	tropolone	COMT	MESH:D014334	24267(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Comparative effect of tropolone and diosmin on venous COMT and sympathetic activity in rat .
2126354	0	tropolone	72,81	catechol-O-methyltransferase	85,113	tropolone	catechol-O-methyltransferase	MESH:D014334	24267(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Augmentation of the sterilizing effect of neonatal androgenization with tropolone , a catechol-O-methyltransferase inhibitor , in female rats .
5624129	0	tropolone	23,32	catechol-O-methyltransferase	46,74	tropolone	catechol-O-methyltransferase	MESH:D014334	1312	Chemical	Gene	effects|nmod|START_ENTITY analogues|nsubj|effects analogues|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Inhibitory effects of tropolone analogues on catechol-O-methyltransferase -RSB- .
11335715	0	tropomyosin	17,28	Endostatin	0,10	tropomyosin	Endostatin	null	80781	Chemical	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Endostatin binds tropomyosin .
2920831	0	tropomyosin	49,60	deoxyribonuclease_I	66,85	tropomyosin	deoxyribonuclease I	null	100009513(Tax:9986)	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of iodoacetamidofluorescein-labelled tropomyosin with deoxyribonuclease_I .
23665794	0	tropomyosin	28,39	myosin	59,65	tropomyosin	myosin	null	79784	Chemical	Gene	interaction|nmod|START_ENTITY END_ENTITY|nsubj|interaction	Inverse interaction between tropomyosin and phosphorylated myosin in the presence or absence of caldesmon .
3496963	0	tropomyosin	44,55	transforming_growth_factor_alpha	88,120	tropomyosin	transforming growth factor alpha	null	24827(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|fibroblasts fibroblasts|nmod|END_ENTITY	Suppression of synthesis and utilization of tropomyosin in mouse and rat fibroblasts by transforming_growth_factor_alpha : a pathway in oncogene action .
11112516	0	troponin	148,156	troponin_C	130,140	troponin	troponin C	null	3371	Chemical	Gene	complex|compound|START_ENTITY END_ENTITY|nmod|complex	Proximity relationships between residue 6 of troponin_I and residues in troponin_C : further evidence for extended conformation of troponin_C in the troponin complex .
447622	0	troponin-I	15,25	troponin-T	31,41	troponin-I	troponin-T	null	7138	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of troponin-I with troponin-T and its fragment .
11591369	0	troponin_I	52,62	cardiac_troponin_C	33,51	troponin I	cardiac troponin C	null	7134	Chemical	Gene	complex|compound|START_ENTITY complex|amod|END_ENTITY	Interaction of bepridil with the cardiac_troponin_C / troponin_I complex .
9299323	0	troponin_I	100,110	troponin_C	51,61	troponin I	troponin C	null	100301551(Tax:9986)	Chemical	Gene	site|nmod|START_ENTITY site|amod|END_ENTITY	Mapping of a second actin-tropomyosin and a second troponin_C binding site within the C terminus of troponin_I , and their importance in the Ca2 + - dependent regulation of muscle contraction .
10628907	0	trospium_chloride	22,39	cytochrome_P450	43,58	trospium chloride	cytochrome P450	MESH:C003330	4051	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|enzymes enzymes|amod|END_ENTITY	Inhibitory effects of trospium_chloride on cytochrome_P450 enzymes in human liver microsomes .
19389858	0	trospium_chloride	124,141	p-glycoprotein	12,26	trospium chloride	p-glycoprotein	MESH:C003330	67078(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	The role of p-glycoprotein in limiting brain penetration of the peripherally acting anticholinergic overactive_bladder drug trospium_chloride .
10822086	0	trovafloxacin	11,24	E-selectin	61,71	trovafloxacin	E-selectin	MESH:C080163	6401	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activation activation|nmod|END_ENTITY	Effects of trovafloxacin on the IL-1-dependent activation of E-selectin in human endothelial cells in vitro .
8879546	0	trypanothione	75,88	glutathione_reductase	46,67	trypanothione	glutathione reductase	MESH:C044809	2936	Chemical	Gene	inhibitors|amod|START_ENTITY END_ENTITY|nmod|inhibitors	Charge is the major discriminating factor for glutathione_reductase versus trypanothione reductase inhibitors .
18321710	0	tryprostatin_A	57,71	breast_cancer_resistance_protein	89,121	tryprostatin A	breast cancer resistance protein	MESH:C097858	9429	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Synthesis and structure-activity relationship studies on tryprostatin_A , an inhibitor of breast_cancer_resistance_protein .
6177314	1	trypsin	177,184	alpha_2-macroglobulin	97,118	trypsin	alpha 2-macroglobulin	null	2	Chemical	Gene	Kinetics|nmod|START_ENTITY Kinetics|nmod|END_ENTITY	Kinetics of inactivation of alpha_2-macroglobulin by methylamine , and formation of anomalous complexes with trypsin .
19941898	0	tryptophan	18,28	AHR	0,3	tryptophan	AHR	CHEBI:27897	196	Chemical	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	AHR activation by tryptophan -- pathogenic hallmark of Th17-mediated inflammation in eosinophilic fasciitis , eosinophilia-myalgia-syndrome and toxic_oil_syndrome ?
945332	0	tryptophan	49,59	CSF	45,48	tryptophan	CSF	CHEBI:27897	116630(Tax:10116)	Chemical	Gene	concentrations|compound|START_ENTITY concentrations|compound|END_ENTITY	Relationship between rat brain and cisternal CSF tryptophan concentrations .
10359457	0	tryptophan	64,74	CYP1A1	11,17	tryptophan	CYP1A1	CHEBI:27897	1543	Chemical	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|expression expression|compound|END_ENTITY	UV-induced CYP1A1 gene expression in human cells is mediated by tryptophan .
9566724	0	tryptophan	78,88	CYP1A1	33,39	tryptophan	CYP1A1	CHEBI:27897	1543	Chemical	Gene	cells|nmod|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	Rapid and transient induction of CYP1A1 gene expression in human cells by the tryptophan photoproduct 6-formylindolo -LSB- 3,2-b -RSB- carbazole .
16206234	0	tryptophan	9,19	DAP12	71,76	tryptophan	DAP12	CHEBI:27897	22177(Tax:10090)	Chemical	Gene	catabolism|compound|START_ENTITY catabolism|nmod|END_ENTITY	Enhanced tryptophan catabolism in the absence of the molecular adapter DAP12 .
24193022	0	tryptophan	50,60	DPP-IV	39,45	tryptophan	DPP-IV	CHEBI:27897	1803	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of dipeptidyl_peptidase_IV -LRB- DPP-IV -RRB- by tryptophan containing dipeptides .
15820717	0	tryptophan	33,43	Estrogen_receptor-beta	0,22	tryptophan	Estrogen receptor-beta	CHEBI:27897	13983(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Estrogen_receptor-beta regulates tryptophan hydroxylase-1 expression in the murine midbrain raphe .
22068654	3	tryptophan	422,432	IDO	447,450	tryptophan	IDO	CHEBI:27897	3620	Chemical	Gene	catabolism|compound|START_ENTITY catabolism|nmod|END_ENTITY	However , the exact role of tryptophan catabolism by IDO in human cancers remains poorly understood .
979999	0	tryptophan	64,74	Insulin	0,7	tryptophan	Insulin	CHEBI:27897	3630	Chemical	Gene	levels|nmod|START_ENTITY influence|nmod|levels secretion|dep|influence secretion|compound|END_ENTITY	Insulin secretion in migraine : influence on the blood levels of tryptophan .
993793	0	tryptophan	41,51	Insulin	0,7	tryptophan	Insulin	CHEBI:27897	3630	Chemical	Gene	decrease|nmod|START_ENTITY therapy|dep|decrease therapy|compound|END_ENTITY	Insulin coma therapy : decrease of plasma tryptophan in man .
3369564	0	tryptophan	22,32	Prolactin	0,9	tryptophan	Prolactin	CHEBI:27897	5617	Chemical	Gene	START_ENTITY|nsubj|response response|compound|END_ENTITY	Prolactin response to tryptophan during mianserin treatment .
6703856	1	tryptophan	71,81	Prolactin	37,46	tryptophan	Prolactin	CHEBI:27897	5617	Chemical	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Prolactin response to intravenous tryptophan in depressed patients and healthy subjects .
18522536	0	tryptophan	15,25	SLC6A14	43,50	tryptophan	SLC6A14	CHEBI:27897	11254	Chemical	Gene	derivatives|compound|START_ENTITY derivatives|nmod|END_ENTITY	Interaction of tryptophan derivatives with SLC6A14 -LRB- ATB0 , + -RRB- reveals the potential of the transporter as a drug target for cancer chemotherapy .
19015006	0	tryptophan	58,68	TPH-1	82,87	tryptophan	TPH-1	CHEBI:27897	7166	Chemical	Gene	hydroxylase|nmod:npmod|START_ENTITY genes|amod|hydroxylase genes|dep|END_ENTITY	Molecular cloning , characterization and expression of two tryptophan hydroxylase -LRB- TPH-1 and TPH-2 -RRB- genes in the hypothalamus of Atlantic croaker : down-regulation after chronic exposure to hypoxia .
15124006	0	tryptophan	38,48	TPH2	70,74	tryptophan	TPH2	CHEBI:27897	121278	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	SNP and haplotype analysis of a novel tryptophan hydroxylase isoform -LRB- TPH2 -RRB- gene provide evidence for association with major_depression .
15768392	0	tryptophan	72,82	TPH2	101,105	tryptophan	TPH2	CHEBI:27897	121278	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Possible association between autism and variants in the brain-expressed tryptophan hydroxylase gene -LRB- TPH2 -RRB- .
17015812	0	tryptophan	30,40	TPH2	54,58	tryptophan	TPH2	CHEBI:27897	121278	Chemical	Gene	hydroxylase|compound|START_ENTITY Association|nmod|hydroxylase Association|appos|END_ENTITY	Association of brain-specific tryptophan hydroxylase , TPH2 , with unipolar_and_bipolar_disorder in a Northern Swedish , isolated population .
21129470	0	tryptophan	42,52	TPH2	66,70	tryptophan	TPH2	CHEBI:27897	317675(Tax:10116)	Chemical	Gene	hydroxylase|compound|START_ENTITY hydroxylase|appos|END_ENTITY	Bacopa monniera leaf extract up-regulates tryptophan hydroxylase -LRB- TPH2 -RRB- and serotonin_transporter -LRB- SERT -RRB- expression : implications in memory formation .
2806911	0	tryptophan	54,64	TRP1	30,34	tryptophan	TRP1	CHEBI:27897	851570(Tax:4932)	Chemical	Gene	coding|nmod|START_ENTITY gene|acl|coding END_ENTITY|appos|gene	Molecular characterization of TRP1 , a gene coding for tryptophan synthetase in the basidiomycete Coprinus_cinereus .
3286643	0	tryptophan	35,45	TRP1	16,20	tryptophan	TRP1	CHEBI:27897	851570(Tax:4932)	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	The role of the TRP1 gene in yeast tryptophan biosynthesis .
15490173	0	tryptophan	28,38	Tat2p	22,27	tryptophan	Tat2p	CHEBI:27897	854139(Tax:4932)	Chemical	Gene	permease|compound|START_ENTITY permease|amod|END_ENTITY	Activity of the yeast Tat2p tryptophan permease is sensitive to the anti-tumor agent 4-phenylbutyrate .
16268992	0	tryptophan	50,60	Tph2	20,24	tryptophan	Tph2	CHEBI:27897	216343(Tax:10090)	Chemical	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Association between Tph2 gene polymorphism , brain tryptophan hydroxylase activity and aggressiveness in mouse strains .
19884191	0	tryptophan	67,77	albumin	45,52	tryptophan	albumin	CHEBI:27897	213	Chemical	Gene	residue|compound|START_ENTITY END_ENTITY|nmod|residue	Multiple conformational state of human serum albumin around single tryptophan residue at various pH revealed by time-resolved fluorescence spectroscopy .
16520086	0	tryptophan	88,98	alcohol_dehydrogenase	111,132	tryptophan	alcohol dehydrogenase	CHEBI:27897	10327	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	Two-dimensional fluorescence correlation spectroscopy IV : resolution of fluorescence of tryptophan residues in alcohol_dehydrogenase and lysozyme .
1702023	0	tryptophan	41,51	alpha-fetoprotein	67,84	tryptophan	alpha-fetoprotein	CHEBI:27897	24177(Tax:10116)	Chemical	Gene	residue|compound|START_ENTITY residue|nmod|END_ENTITY	Time-resolved fluorescence of the single tryptophan residue in rat alpha-fetoprotein and rat serum albumin : analysis by the maximum-entropy method .
410450	0	tryptophan	27,37	alpha-lactalbumin	56,73	tryptophan	alpha-lactalbumin	CHEBI:27897	281894(Tax:9913)	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	On the reactivities of the tryptophan residues of human alpha-lactalbumin to 2-hydroxy-5-nitrobenzyl_bromide .
16249825	0	tryptophan	34,44	alpha_2_type_IX_collagen	4,28	tryptophan	alpha 2 type IX collagen	CHEBI:27897	1298	Chemical	Gene	polymorphism|compound|START_ENTITY polymorphism|amod|END_ENTITY	The alpha_2_type_IX_collagen gene tryptophan polymorphism is not associated with rheumatoid_arthritis in the Japanese population .
10451359	0	tryptophan	31,41	annexin_V	71,80	tryptophan	annexin V	CHEBI:27897	308	Chemical	Gene	residue|compound|START_ENTITY residue|nmod|END_ENTITY	Atomic mutations at the single tryptophan residue of human recombinant annexin_V : effects on structure , stability , and activity .
16128566	0	tryptophan	14,24	antithrombin	31,43	tryptophan	antithrombin	CHEBI:27897	462	Chemical	Gene	Importance|nmod|START_ENTITY Importance|nmod|END_ENTITY	Importance of tryptophan 49 of antithrombin in heparin binding and conformational activation .
7766701	0	tryptophan	21,31	apolipoprotein_B	44,60	tryptophan	apolipoprotein B	CHEBI:27897	338	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	Early destruction of tryptophan residues of apolipoprotein_B is a vitamin_E-independent process during copper-mediated oxidation of LDL .
10951567	0	tryptophan	36,46	c-Raf	50,55	tryptophan	c-Raf	CHEBI:27897	5894	Chemical	Gene	function|nmod|START_ENTITY function|nmod|END_ENTITY	A different function for a critical tryptophan in c-Raf and Hck .
8031716	0	tryptophan	17,27	corticosteroid-binding_globulin	46,77	tryptophan	corticosteroid-binding globulin	CHEBI:27897	866	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	Substitutions of tryptophan residues in human corticosteroid-binding_globulin : impact on steroid binding and glycosylation .
1751755	0	tryptophan	14,24	cytochrome_P-450	68,84	tryptophan	cytochrome P-450	CHEBI:27897	25251(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|induction induction|nmod|END_ENTITY	The effect of tryptophan on the phenobarbital-mediated induction of cytochrome_P-450 in rat liver .
1931948	0	tryptophan	59,69	cytochrome_b5	31,44	tryptophan	cytochrome b5	CHEBI:27897	100328915(Tax:9986)	Chemical	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	Fluorescence study of a mutant cytochrome_b5 with a single tryptophan in the membrane-binding domain .
7707377	0	tryptophan	17,27	dihydrofolate_reductase	118,141	tryptophan	dihydrofolate reductase	CHEBI:27897	1719	Chemical	Gene	Contributions|nmod|START_ENTITY Contributions|nmod|END_ENTITY	Contributions of tryptophan 24 and glutamate 30 to binding long-lived water molecules in the ternary complex of human dihydrofolate_reductase with methotrexate and NADPH studied by site-directed mutagenesis and nuclear magnetic resonance spectroscopy .
24193022	0	tryptophan	50,60	dipeptidyl_peptidase_IV	14,37	tryptophan	dipeptidyl peptidase IV	CHEBI:27897	1803	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of dipeptidyl_peptidase_IV -LRB- DPP-IV -RRB- by tryptophan containing dipeptides .
6149728	0	tryptophan	78,88	dipeptidyl_peptidase_iv	25,48	tryptophan	dipeptidyl peptidase iv	CHEBI:27897	397492(Tax:9823)	Chemical	Gene	residue|compound|START_ENTITY involvement|nmod|residue modification|dep|involvement modification|nmod|END_ENTITY	Chemical modification of dipeptidyl_peptidase_iv : involvement of an essential tryptophan residue at the substrate binding site .
17593322	0	tryptophan	9,19	endomannosidase	31,46	tryptophan	endomannosidase	CHEBI:27897	79694	Chemical	Gene	residue|compound|START_ENTITY residue|nmod|END_ENTITY	A single tryptophan residue of endomannosidase is crucial for Golgi localization and in vivo activity .
16307304	0	tryptophan	33,43	ferredoxin	95,105	tryptophan	ferredoxin	CHEBI:27897	100280635(Tax:4577)	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	Chemical modification studies of tryptophan , arginine and lysine residues in maize chloroplast ferredoxin : sulfite oxidoreductase .
6277651	0	tryptophan	33,43	gastrin	55,62	tryptophan	gastrin	CHEBI:27897	25320(Tax:10116)	Chemical	Gene	residue|compound|START_ENTITY residue|nmod|END_ENTITY	Effect of Nin-formylation of the tryptophan residue on gastrin -LRB- HG-13 -RRB- binding and on gastric acid secretion .
7317525	0	tryptophan	9,19	histidine_decarboxylase	49,72	tryptophan	histidine decarboxylase	CHEBI:27897	3067	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	-LSB- Role of tryptophan in the enzymatic activity of histidine_decarboxylase from Micrococcus sp .
1722997	0	tryptophan	18,28	insulin	121,128	tryptophan	insulin	CHEBI:27897	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|relationship relationship|nmod|END_ENTITY	Effect of dietary tryptophan on muscle , liver and whole-body protein synthesis in weaned piglets : relationship to plasma insulin .
3890175	0	tryptophan	48,58	insulin	27,34	tryptophan	insulin	CHEBI:27897	3630	Chemical	Gene	substitutions|compound|START_ENTITY analogs|nmod|substitutions analogs|nsubj|properties properties|nmod|END_ENTITY	Fluorescence properties of insulin analogs with tryptophan substitutions .
6091659	0	tryptophan	33,43	insulin	22,29	tryptophan	insulin	CHEBI:27897	280829(Tax:9913)	Chemical	Gene	transport|compound|START_ENTITY END_ENTITY|nmod|transport	On the stimulation by insulin of tryptophan transport across the blood-brain barrier .
6351935	0	tryptophan	5,15	insulin	40,47	tryptophan	insulin	CHEBI:27897	3630	Chemical	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	Free tryptophan response to intravenous insulin in depressed patients .
7021801	0	tryptophan	41,51	insulin	14,21	tryptophan	insulin	CHEBI:27897	100009181(Tax:9986)	Chemical	Gene	influx|nmod|START_ENTITY effect|nmod|influx effect|nmod|END_ENTITY	The effect of insulin upon the influx of tryptophan into the brain of the rabbit .
6487363	0	tryptophan	15,25	lysozyme	38,46	tryptophan	lysozyme	CHEBI:27897	4069	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	Involvement of tryptophan residues of lysozyme in its binding with cytosine_arabinoside .
9398147	0	tryptophan	14,24	melittin	55,63	tryptophan	melittin	CHEBI:27897	406130(Tax:7460)	Chemical	Gene	environment|compound|START_ENTITY environment|nmod|END_ENTITY	Modulation of tryptophan environment in membrane-bound melittin by negatively charged phospholipids : implications in membrane organization and function .
432955	0	tryptophan	34,44	myosin	61,67	tryptophan	myosin	CHEBI:27897	79784	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	-LSB- Nature of the orientation of the tryptophan residues in the myosin and actin from striated muscle fiber -RSB- .
16081046	0	tryptophan	13,23	neprilysin_2	35,47	tryptophan	neprilysin 2	CHEBI:27897	27390(Tax:10090)	Chemical	Gene	residue|compound|START_ENTITY residue|nmod|END_ENTITY	The ultimate tryptophan residue of neprilysin_2 is not involved in protein maturation and enzymatic activity .
9368011	0	tryptophan	71,81	p47phox	57,64	tryptophan	p47phox	CHEBI:27897	653361	Chemical	Gene	using|dobj|START_ENTITY END_ENTITY|acl|using	Analysis of activation-induced conformational changes in p47phox using tryptophan fluorescence spectroscopy .
1888737	0	tryptophan	173,183	phospholipase_A2	83,99	tryptophan	phospholipase A2	CHEBI:27897	151056	Chemical	Gene	residue|compound|START_ENTITY study|nmod|residue Insight|nmod|study Insight|nmod|END_ENTITY	Insight into the conformational dynamics of specific regions of porcine pancreatic phospholipase_A2 from a time-resolved fluorescence study of a genetically inserted single tryptophan residue .
3219357	0	tryptophan	34,44	phospholipase_A2	67,83	tryptophan	phospholipase A2	CHEBI:27897	151056	Chemical	Gene	dynamics|nmod|START_ENTITY dynamics|nmod|END_ENTITY	Rotational dynamics of the single tryptophan of porcine pancreatic phospholipase_A2 , its zymogen , and an enzyme/micelle complex .
3350151	0	tryptophan	62,72	phospholipase_A2	95,111	tryptophan	phospholipase A2	CHEBI:27897	151056	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	Proton NMR resonance assignments and surface accessibility of tryptophan residues of a dimeric phospholipase_A2 from Trimeresurus flavoviridis .
3818568	0	tryptophan	22,32	phospholipase_A2	106,122	tryptophan	phospholipase A2	CHEBI:27897	151056	Chemical	Gene	residue|compound|START_ENTITY Identification|nmod|residue flavoviridis|nsubj|Identification flavoviridis|dobj|END_ENTITY	Identification of the tryptophan residue located in the calcium binding site of Trimeresurus flavoviridis phospholipase_A2 .
4084578	0	tryptophan	35,45	phospholipase_A2	68,84	tryptophan	phospholipase A2	CHEBI:27897	151056	Chemical	Gene	photophysics|nmod|START_ENTITY photophysics|nmod|END_ENTITY	Complex photophysics of the single tryptophan of porcine pancreatic phospholipase_A2 , its zymogen , and an enzyme/micelle complex .
952941	0	tryptophan	13,23	phospholipase_A2	46,62	tryptophan	phospholipase A2	CHEBI:27897	151056	Chemical	Gene	START_ENTITY|nmod|site site|nmod|END_ENTITY	An essential tryptophan in the active site of phospholipase_A2 from the venom of Bitis gabonica .
6256349	0	tryptophan	11,21	placental_lactogen	39,57	tryptophan	placental lactogen	CHEBI:27897	1443	Chemical	Gene	residue|compound|START_ENTITY residue|nmod|END_ENTITY	The single tryptophan residue of human placental_lactogen .
10221360	0	tryptophan	26,36	prolactin	49,58	tryptophan	prolactin	CHEBI:27897	24683(Tax:10116)	Chemical	Gene	diet|compound|START_ENTITY diet|nmod|responses responses|compound|END_ENTITY	Effect of a long-term low tryptophan diet on the prolactin responses to the 5-HT1A and 5-HT2C agonists , 8-OH-DPAT and mCPP in the male rat .
11518476	0	tryptophan	16,26	prolactin	39,48	tryptophan	prolactin	CHEBI:27897	24683(Tax:10116)	Chemical	Gene	diet|compound|START_ENTITY diet|nmod|responses responses|compound|END_ENTITY	Effect of a low tryptophan diet on the prolactin responses to the 5-HT2A agonist DOI in the rat .
1752717	0	tryptophan	27,37	prolactin	70,79	tryptophan	prolactin	CHEBI:27897	5617	Chemical	Gene	fractions|compound|START_ENTITY changes|nmod|fractions changes|nmod|END_ENTITY	Exercise changes in plasma tryptophan fractions and relationship with prolactin .
20384451	0	tryptophan	48,58	prolactin	26,35	tryptophan	prolactin	CHEBI:27897	5617	Chemical	Gene	differences|acl|START_ENTITY differences|nmod|response response|compound|END_ENTITY	Sex differences in plasma prolactin response to tryptophan in chronic_fatigue_syndrome patients with and without comorbid fibromyalgia .
22302954	0	tryptophan	170,180	prolactin	75,84	tryptophan	prolactin	CHEBI:27897	24683(Tax:10116)	Chemical	Gene	diet|compound|START_ENTITY rat|nmod|diet neuroendocrine|nmod|rat END_ENTITY|xcomp|neuroendocrine	Effect of castration and castration with hormone replacement on the plasma prolactin responses to neuroendocrine challenge with i.v. mCPP in the male rat following a low tryptophan diet .
9189307	0	tryptophan	37,47	prolactin	95,104	tryptophan	prolactin	CHEBI:27897	5617	Chemical	Gene	intensity|nmod|START_ENTITY Effect|nmod|intensity amino_acids|nsubj|Effect amino_acids|dobj|END_ENTITY	Effect of exercise intensity on free tryptophan to branched-chain amino_acids ratio and plasma prolactin during endurance exercise .
19383525	0	tryptophan	29,39	soybean_agglutinin	77,95	tryptophan	soybean agglutinin	CHEBI:27897	100818710	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	Organization and dynamics of tryptophan residues in tetrameric and monomeric soybean_agglutinin : studies by steady-state and time-resolved fluorescence , phosphorescence and chemical modification .
403956	0	tryptophan	20,30	thrombin	41,49	tryptophan	thrombin	CHEBI:27897	280685(Tax:9913)	Chemical	Gene	modification|nmod|START_ENTITY modification|nmod|END_ENTITY	The modification of tryptophan in bovine thrombin .
12135927	0	tryptophan	74,84	tph-1	68,73	tryptophan	tph-1	CHEBI:27897	174227(Tax:6239)	Chemical	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	The C. _ elegans POU-domain transcription factor UNC-86 regulates the tph-1 tryptophan hydroxylase gene and neurite outgrowth in specific serotonergic neurons .
850134	0	tryptophan	61,71	tryptophan_hydroxylase	20,42	tryptophan	tryptophan hydroxylase	CHEBI:27897	24848(Tax:10116)	Chemical	Gene	content|compound|START_ENTITY END_ENTITY|nmod|content	Modulation of brain tryptophan_hydroxylase activity by brain tryptophan content .
19201692	0	tryptophan	66,76	tryptophan_pyrrolase	20,40	tryptophan	tryptophan pyrrolase	CHEBI:27897	6999	Chemical	Gene	availability|compound|START_ENTITY decrease|nmod|availability mediates|dobj|decrease mediates|nsubj|Activation Activation|nmod|END_ENTITY	Activation of liver tryptophan_pyrrolase mediates the decrease in tryptophan availability to the brain after acute alcohol consumption by normal subjects .
2468750	0	tryptophan	77,87	tryptophan_pyrrolase	24,44	tryptophan	tryptophan pyrrolase	CHEBI:27897	64206(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY activity|nmod|concentration END_ENTITY|dobj|activity	Inhibition of rat liver tryptophan_pyrrolase activity and elevation of brain tryptophan concentration by administration of DL-alpha-amino-beta-pyridinepropanoic_acid -LRB- pyridylalanine -RRB- analogs .
454365	0	tryptophan	25,35	tryptophan_pyrrolase	125,145	tryptophan	tryptophan pyrrolase	CHEBI:27897	64206(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|administration administration|nmod|activity activity|compound|END_ENTITY	Enhancement of rat brain tryptophan metabolism by chronic ethanol administration and possible involvement of decreased liver tryptophan_pyrrolase activity .
7126996	0	tryptophan	77,87	tryptophan_pyrrolase	24,44	tryptophan	tryptophan pyrrolase	CHEBI:27897	64206(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY activity|nmod|concentration END_ENTITY|dobj|activity	Inhibition of rat liver tryptophan_pyrrolase activity and elevation of brain tryptophan concentration by acute administration of small doses of antidepressants .
7197926	0	tryptophan	151,161	tryptophan_pyrrolase	18,38	tryptophan	tryptophan pyrrolase	CHEBI:27897	64206(Tax:10116)	Chemical	Gene	metabolism|compound|START_ENTITY END_ENTITY|nmod|metabolism	The role of liver tryptophan_pyrrolase in the opposite effects of chronic administration and subsequent withdrawal of drugs of dependence on rat brain tryptophan metabolism .
7271819	0	tryptophan	77,87	tryptophan_pyrrolase	24,44	tryptophan	tryptophan pyrrolase	CHEBI:27897	64206(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY activity|nmod|concentration END_ENTITY|dobj|activity	Inhibition of rat liver tryptophan_pyrrolase activity and elevation of brain tryptophan concentration by administration of antidepressants .
5934497	0	tryptophan	50,60	tryptophanase	22,35	tryptophan	tryptophanase	CHEBI:27897	6999	Chemical	Gene	control|nmod|START_ENTITY END_ENTITY|nmod|control	Physiological role of tryptophanase in control of tryptophan biosynthesis in Bacillus alvei .
6692836	0	tryptophan	51,61	tryptophanyl-tRNA_synthetase	65,93	tryptophan	tryptophanyl-tRNA synthetase	CHEBI:27897	7453	Chemical	Gene	investigation|nmod|START_ENTITY investigation|nmod|END_ENTITY	An investigation of the mechanism of activation of tryptophan by tryptophanyl-tRNA_synthetase from beef pancreas .
3049162	0	tryptophan	14,24	tumor_necrosis_factor	37,58	tryptophan	tumor necrosis factor	CHEBI:27897	21926(Tax:10090)	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	Two conserved tryptophan residues of tumor_necrosis_factor and lymphotoxin are not involved in the biological activity .
8224374	0	tryptophan	14,24	tyrosinase	58,68	tryptophan	tyrosinase	CHEBI:27897	7299	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of tryptophan on dopa-oxidation by melanosomal tyrosinase .
11149488	0	tryptophan	11,21	vitamin_D_receptor	37,55	tryptophan	vitamin D receptor	CHEBI:27897	7421	Chemical	Gene	residue|compound|START_ENTITY residue|nmod|END_ENTITY	The unique tryptophan residue of the vitamin_D_receptor is critical for ligand binding and transcriptional activation .
19410464	0	tryptophan_sulfonamide	26,48	TNF-alpha_converting_enzyme	86,113	tryptophan sulfonamide	TNF-alpha converting enzyme	null	6868	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Synthesis and activity of tryptophan_sulfonamide derivatives as novel non-hydroxamate TNF-alpha_converting_enzyme -LRB- TACE -RRB- inhibitors .
527591	0	tryptophanyl	69,81	antithrombin	101,113	tryptophanyl	antithrombin	null	462	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Evidence by chemical modification for the involvement of one or more tryptophanyl residues of bovine antithrombin in the binding of high-affinity heparin .
10866792	0	tryptophanyl	14,26	myoglobin	68,77	tryptophanyl	myoglobin	null	4151	Chemical	Gene	substitution|amod|START_ENTITY effect|nmod|substitution effect|nmod|END_ENTITY	The effect of tryptophanyl substitution on folding and structure of myoglobin .
2383545	0	tryptophyl	35,45	myoglobin	58,67	tryptophyl	myoglobin	CHEBI:37899	102975021	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Fluorescence decay kinetics of the tryptophyl residues of myoglobin : effect of heme ligation and evidence for discrete lifetime components .
20614936	0	tubastatin_A	88,100	HDAC6	71,76	tubastatin A	HDAC6	MESH:C553587	10013	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Rational design and simple chemistry yield a superior , neuroprotective HDAC6 inhibitor , tubastatin_A .
10535221	0	tuberculin	16,26	GT_1	37,41	tuberculin	GT 1	MESH:D014373	2683	Chemical	Gene	test|compound|START_ENTITY test|nmod|END_ENTITY	-LSB- Mendel-Mantoux tuberculin test with GT_1 in the public health office -RSB- .
15150271	0	tuberin	39,46	B-Raf	14,19	tuberin	B-Raf	null	673	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian_target_of_rapamycin -LRB- mTOR -RRB- - independent .
25142998	0	tubulointerstitium	123,141	Activin_A	66,75	tubulointerstitium	Activin A	null	29200(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of tripterygium_wilfordii_polyglucoside on expression of Activin_A and influence of transdifferentiation in renal tubulointerstitium of rats with diabetic_nephropathy -RSB- .
11544339	0	tubulointerstitium	56,74	Midkine	0,7	tubulointerstitium	Midkine	null	17242(Tax:10090)	Chemical	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	Midkine is involved in neutrophil infiltration into the tubulointerstitium in ischemic_renal_injury .
8099880	0	tulobuterol	57,68	beta_2-adrenoceptor	28,47	tulobuterol	beta 2-adrenoceptor	MESH:C010809	154	Chemical	Gene	agonist|appos|START_ENTITY agonist|amod|END_ENTITY	The pharmacokinetics of the beta_2-adrenoceptor agonist , tulobuterol , given transdermally and by inhalation .
17914579	0	tunicamycin	125,136	TRAIL-R1	24,32	tunicamycin	TRAIL-R1	MESH:D014415	8797	Chemical	Gene	protein|nmod|START_ENTITY END_ENTITY|dep|protein	Glycosylation modulates TRAIL-R1 / death_receptor_4 protein : different regulations of two pro-apoptotic receptors for TRAIL by tunicamycin .
3733260	0	tunicamycin	10,21	carcinoembryonic_antigen	52,76	tunicamycin	carcinoembryonic antigen	MESH:D014415	1084	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of tunicamycin on synthesis and secretion of carcinoembryonic_antigen by human colonic_adenocarcinoma cells .
6205259	0	tunicamycin	159,170	carcinoembryonic_antigen	77,101	tunicamycin	carcinoembryonic antigen	MESH:D014415	1084	Chemical	Gene	presence|nmod|START_ENTITY synthesized|nmod|presence synthesized|nsubj|characterization characterization|nmod|peptide peptide|nmod|END_ENTITY	Identification and partial characterization of the unglycosylated peptide of carcinoembryonic_antigen synthesized by human tumor cell lines in the presence of tunicamycin .
19643964	7	tunicamycin	1405,1416	caspase-4	1367,1376	tunicamycin	caspase-4	MESH:D014415	837	Chemical	Gene	activities|nmod|START_ENTITY activities|amod|END_ENTITY	The induced caspase-4 and caspase-3 activities by tunicamycin and the stimulated IL-8 protein expression by IL-1beta were markedly reduced by caspase-4 inhibitor Z-LEVD-fmk .
24576488	0	tunicamycin	79,90	inducible_nitric_oxide_synthase	14,45	tunicamycin	inducible nitric oxide synthase	MESH:D014415	4843	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Inhibition of inducible_nitric_oxide_synthase and interleukin-1b expression by tunicamycin in cultured glial cells exposed to lipopolysaccharide .
17131418	0	tunicamycin	79,90	p53	8,11	tunicamycin	p53	MESH:D014415	301300(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Role Role|nmod|END_ENTITY	Role of p53 in neurotoxicity induced by the endoplasmic reticulum stress agent tunicamycin in organotypic slice cultures of rat spinal cord .
7117256	0	tunicamycin	10,21	thyroglobulin	25,38	tunicamycin	thyroglobulin	MESH:D014415	24826(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of tunicamycin on thyroglobulin secretion .
6092384	0	tunicamycin	10,21	thyroxine-binding_globulin	51,77	tunicamycin	thyroxine-binding globulin	MESH:D014415	6906	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|cells cells|amod|END_ENTITY	Effect of tunicamycin and monensin on secretion of thyroxine-binding_globulin by cultured human hepatoma -LRB- Hep G2 -RRB- cells .
1713523	0	turpentine	10,20	alpha_1-major_acute_phase	24,49	turpentine	alpha 1-major acute phase	MESH:D014425	24903(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|concentration concentration|amod|END_ENTITY	Effect of turpentine on alpha_1-major_acute_phase concentration in normal and adrenalectomized rats .
15640832	0	turpentine	41,51	heme_oxygenase-1	16,32	turpentine	heme oxygenase-1	MESH:D014425	24451(Tax:10116)	Chemical	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Upregulation of heme_oxygenase-1 gene by turpentine oil-induced localized inflammation : involvement of interleukin-6 .
1719958	0	turpentine	142,152	interleukin-1_beta	29,47	turpentine	interleukin-1 beta	MESH:D014425	3553	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Effects Effects|nmod|END_ENTITY	Effects of human recombinant interleukin-1_beta on protein synthesis in rat tissues compared with a classical acute-phase reaction induced by turpentine .
22963406	0	tyramine	47,55	BL0076	102,108	tyramine	BL0076	MESH:D014439	1022223(Tax:206672)	Chemical	Gene	START_ENTITY|acl|produced produced|nmod|END_ENTITY	Tyrosine-containing peptides are precursors of tyramine produced by Lactobacillus_plantarum_strain IR BL0076 isolated from wine .
15953361	0	tyramine	44,52	TYRA-2	0,6	tyramine	TYRA-2	MESH:D014439	180970(Tax:6239)	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|dep|receptor	TYRA-2 -LRB- F01E11 .5 -RRB- : a Caenorhabditis_elegans tyramine receptor expressed in the MC and NSM pharyngeal neurons .
2127505	0	tyramine	111,119	monoamine_oxidase	22,39	tyramine	monoamine oxidase	MESH:D014439	29253(Tax:10116)	Chemical	Gene	inhibitors|xcomp|START_ENTITY inhibitors|nsubj|effect effect|nmod|END_ENTITY	The effect of various monoamine_oxidase -LRB- MAO -RRB- inhibitors on the response of blood pressure of rats and cats to tyramine .
446597	0	tyramine	64,72	monoamine_oxidase	28,45	tyramine	monoamine oxidase	MESH:D014439	29253(Tax:10116)	Chemical	Gene	activities|nmod|START_ENTITY activities|amod|END_ENTITY	Effects of thyroidectomy on monoamine_oxidase activities toward tyramine and serotonin in the circumventricular nuclei of the rat .
6830619	0	tyramine	25,33	monoamine_oxidase	51,68	tyramine	monoamine oxidase	MESH:D014439	29253(Tax:10116)	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|nmod|forms forms|nmod|END_ENTITY	Intestinal metabolism of tyramine by both forms of monoamine_oxidase in the rat .
17178862	0	tyrosil	62,69	major_vault_protein	129,148	tyrosil	major vault protein	null	9961	Chemical	Gene	modification|amod|START_ENTITY modification|nmod|END_ENTITY	Nuclear localization of PTEN is regulated by Ca -LRB- 2 + -RRB- through a tyrosil phosphorylation-independent conformational modification in major_vault_protein .
19289463	0	tyrosine	26,34	14-3-3zeta	0,10	tyrosine	14-3-3zeta	CHEBI:18186	7534	Chemical	Gene	contributes|xcomp|START_ENTITY contributes|nsubj|END_ENTITY	14-3-3zeta contributes to tyrosine hydroxylase activity in MN9D cells : localization of dopamine regulatory proteins to mitochondria .
9556211	0	tyrosine	24,32	A19	20,23	tyrosine	A19	CHEBI:18186	28921	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of deleting A19 tyrosine from insulin .
11314040	0	tyrosine	45,53	AATYK	62,67	tyrosine	AATYK	CHEBI:18186	11302(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	Characterization of the apoptosis-associated tyrosine kinase -LRB- AATYK -RRB- expressed in the CNS .
17312388	0	tyrosine	90,98	ABCG2	23,28	tyrosine	ABCG2	CHEBI:18186	9429	Chemical	Gene	START_ENTITY|nsubj|Association Association|nmod|END_ENTITY	Association of variant ABCG2 and the pharmacokinetics of epidermal_growth_factor_receptor tyrosine kinase inhibitors in cancer patients .
12609966	0	tyrosine	33,41	ABIN-2	109,115	tyrosine	ABIN-2	CHEBI:18186	79155	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|nmod|END_ENTITY	The antiinflammatory endothelial tyrosine kinase Tie2 interacts with a novel nuclear factor-kappaB inhibitor ABIN-2 .
12543778	5	tyrosine	874,882	ABL	832,835	tyrosine	ABL	CHEBI:18186	25	Chemical	Gene	phosphorylation|amod|START_ENTITY inhibited|dobj|phosphorylation inhibited|nsubj|Addition Addition|nmod|STI-571 STI-571|nmod|cells cells|compound|END_ENTITY	Addition of the Abl kinase inhibitor STI-571 to ABL SH2-transformed Rat-1 cells inhibited tyrosine phosphorylation of p145 ABL .
15886098	0	tyrosine	15,23	ABL	11,14	tyrosine	ABL	CHEBI:18186	11350(Tax:10090)	Chemical	Gene	activator|amod|START_ENTITY activator|compound|END_ENTITY	RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration .
16405837	0	tyrosine	17,25	ABL	13,16	tyrosine	ABL	CHEBI:18186	25	Chemical	Gene	START_ENTITY|nsubj|Analysis Analysis|nmod|END_ENTITY	-LSB- Analysis of ABL tyrosine kinase point mutations in imatinib treated chronic_myelogenous_leukemia patients -RSB- .
18603549	0	tyrosine	102,110	ABL	0,3	tyrosine	ABL	CHEBI:18186	25	Chemical	Gene	associated|xcomp|START_ENTITY mutations|acl|associated masquerade|nmod|mutations masquerade|nsubj|polymorphisms polymorphisms|compound|END_ENTITY	ABL single nucleotide polymorphisms may masquerade as BCR-ABL mutations associated with resistance to tyrosine kinase inhibitors in patients with chronic_myeloid_leukemia .
1958595	2	tyrosine	349,357	ABL	410,413	tyrosine	BCR	CHEBI:18186	613	Chemical	Gene	activity|compound|START_ENTITY protein|nmod|activity produces|dobj|protein produces|nmod|that that|nmod|protein protein|compound|END_ENTITY	This produces a fusion protein with a greatly increased protein tyrosine kinase activity in comparison to that of the normal ABL protein .
20805664	0	tyrosine	20,28	ABL	16,19	tyrosine	ABL	CHEBI:18186	25	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	-LSB- Development of ABL tyrosine kinase inhibitors -RSB- .
20841568	0	tyrosine	4,12	ABL	0,3	tyrosine	ABL	CHEBI:18186	25	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	ABL tyrosine kinases : evolution of function , regulation , and specificity .
20929330	0	tyrosine	156,164	ABL	73,76	tyrosine	ABL	CHEBI:18186	25	Chemical	Gene	kinase|amod|START_ENTITY patient|nmod|kinase chronic_myeloid_leukemia|amod|patient compartment|nmod|chronic_myeloid_leukemia stem|dobj|compartment stem|nsubj|analysis analysis|nmod|substitution substitution|nmod|mutations mutations|compound|END_ENTITY	Extensive analysis of the T315I substitution and detection of additional ABL mutations in progenitors and primitive stem cell compartment in a patient with tyrosine kinase inhibitor-resistant chronic_myeloid_leukemia .
21591355	0	tyrosine	135,143	ABL	52,55	tyrosine	ABL	CHEBI:18186	25	Chemical	Gene	-RSB-|amod|START_ENTITY treated|nmod|-RSB- treated|nsubj|Implementation Implementation|nmod|analysis analysis|amod|sequencing sequencing|nmod|method method|nmod|END_ENTITY	-LSB- Implementation of direct sequencing as a method of ABL gene mutations analysis in patients with chronic_myeloid_leukemia treated with tyrosine kinase inhibitor -RSB- .
21961412	0	tyrosine	118,126	ABL	1,4	tyrosine	ABL	CHEBI:18186	25	Chemical	Gene	inhibitors|amod|START_ENTITY chronic_myeloid_leukemia|nmod|inhibitors patients|nmod|chronic_myeloid_leukemia therapy|nmod|patients domain|nmod|therapy domain|nsubj|END_ENTITY	-LSB- ABL domain kinase point mutations as a cause of resistance to therapy of patients with chronic_myeloid_leukemia with tyrosine kinase inhibitors .
23433665	0	tyrosine	144,152	ABL	13,16	tyrosine	ABL	CHEBI:18186	25	Chemical	Gene	inhibitors|compound|START_ENTITY switch|nmod|inhibitors switch|nsubj|Frequency Frequency|nmod|mutations mutations|compound|END_ENTITY	Frequency of ABL gene mutations in chronic_myeloid_leukemia patients resistant to imatinib and results of treatment switch to second-generation tyrosine kinase inhibitors .
23576564	0	tyrosine	24,32	ABL	20,23	tyrosine	ABL	CHEBI:18186	25	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Threshold levels of ABL tyrosine kinase inhibitors retained in chronic myeloid_leukemia cells determine their commitment to apoptosis .
23684619	0	tyrosine	34,42	ABL	30,33	tyrosine	ABL	CHEBI:18186	25	Chemical	Gene	START_ENTITY|nsubj|Efficacy Efficacy|nmod|ponatinib ponatinib|nmod|END_ENTITY	Efficacy of ponatinib against ABL tyrosine kinase inhibitor-resistant leukemia cells .
24147007	0	tyrosine	29,37	ABL	25,28	tyrosine	ABL	CHEBI:18186	25	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Persistent inhibition of ABL tyrosine kinase causes enhanced apoptotic response to TRAIL and disrupts the pro-apoptotic effect of chloroquine .
24265854	0	tyrosine	59,67	ABL	55,58	tyrosine	ABL	CHEBI:18186	25	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	RIN1 regulates cell migration through RAB5 GTPases and ABL tyrosine kinases .
24350829	0	tyrosine	84,92	ABL	80,83	tyrosine	ABL	CHEBI:18186	25	Chemical	Gene	inhibitors|amod|START_ENTITY END_ENTITY|dobj|inhibitors	Downregulation of miR-217 correlates with resistance of Ph -LRB- + -RRB- leukemia cells to ABL tyrosine kinase inhibitors .
25130798	1	tyrosine	339,347	ABL	301,304	tyrosine	ABL	CHEBI:18186	25	Chemical	Gene	kinase|amod|START_ENTITY treatment|amod|kinase mutation|nmod|treatment mutation|compound|END_ENTITY	Most Philadelphia_chromosome-positive_acute_lymphoblastic_leukemia -LRB- Ph -LRB- + -RRB- _ ALL -RRB- patients often show rapid recurrence and development of ABL kinase_domain -LRB- KD -RRB- mutation after tyrosine kinase inhibitor -LRB- TKI -RRB- treatment .
3332851	0	tyrosine	25,33	ABL	12,15	tyrosine	ABL	CHEBI:18186	25	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|oncogene oncogene|compound|END_ENTITY	Role of the ABL oncogene tyrosine kinase activity in human leukaemia .
16820504	0	tyrosine	33,41	ABL-1	27,32	tyrosine	ABL-1	CHEBI:18186	181261(Tax:6239)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The Caenorhabditis_elegans ABL-1 tyrosine kinase is required for Shigella_flexneri pathogenesis .
14733946	0	tyrosine	54,62	ACK	71,74	tyrosine	ACK	CHEBI:18186	10188	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	Cdc42-dependent nuclear translocation of non-receptor tyrosine kinase , ACK .
23597703	0	tyrosine	5,13	ACK1	0,4	tyrosine	ACK1	CHEBI:18186	10188	Chemical	Gene	kinase|amod|START_ENTITY kinase|nummod|END_ENTITY	ACK1 tyrosine kinase : targeted inhibition to block cancer cell proliferation .
20432460	0	tyrosine	46,54	AKT	12,15	tyrosine	AKT	CHEBI:18186	207	Chemical	Gene	kinase|compound|START_ENTITY END_ENTITY|nmod|kinase	Shepherding AKT and androgen_receptor by Ack1 tyrosine kinase .
15226403	0	tyrosine	13,21	ALK	0,3	tyrosine	ALK	CHEBI:18186	238	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth .
21613408	0	tyrosine	75,83	ALK	71,74	tyrosine	ALK	CHEBI:18186	238	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Insights into ALK-driven cancers revealed through development of novel ALK tyrosine kinase inhibitors .
21632861	0	tyrosine	18,26	ALK	5,8	tyrosine	ALK	CHEBI:18186	238	Chemical	Gene	START_ENTITY|nsubj|receptor receptor|compound|END_ENTITY	High ALK receptor tyrosine kinase expression supersedes ALK mutation as a determining factor of an unfavorable phenotype in primary neuroblastoma .
23952683	0	tyrosine	79,87	ALK	75,78	tyrosine	ALK	CHEBI:18186	238	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Insight into crizotinib resistance mechanisms caused by three mutations in ALK tyrosine kinase using free energy calculation approaches .
26973324	1	tyrosine	251,259	ALK	247,250	tyrosine	ALK	D014443	238	Chemical	Gene	inhibitors|amod|START_ENTITY END_ENTITY|dobj|inhibitors	BACKGROUND : ALK-rearranged non-small-cell_lung_cancer -LRB- NSCLC -RRB- is sensitive to ALK tyrosine kinase inhibitors -LRB- ALK inhibitors -RRB- such as crizotinib , but resistance invariably develops , often with progression in the brain .
9053841	0	tyrosine	46,54	ALK	30,33	tyrosine	ALK	CHEBI:18186	11682(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY END_ENTITY|appos|kinase	Molecular characterization of ALK , a receptor tyrosine kinase expressed specifically in the nervous system .
17620104	0	tyrosine	66,74	AMP-activated_protein_kinase	141,169	tyrosine	AMP-activated protein kinase	CHEBI:18186	78975(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	5-Aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside stimulates tyrosine hydroxylase activity and catecholamine secretion by activation of AMP-activated_protein_kinase in PC12 cells .
7679512	0	tyrosine	79,87	ARIA	0,4	tyrosine	ARIA	CHEBI:18186	396452(Tax:9031)	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	ARIA , a protein that stimulates acetylcholine receptor synthesis , also induces tyrosine phosphorylation of a 185-kDa muscle transmembrane protein .
7823930	0	tyrosine	13,21	ARK	29,32	tyrosine	ARK	CHEBI:18186	26362(Tax:10090)	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|ccomp|mediates mediates|nsubj|END_ENTITY	The receptor tyrosine kinase ARK mediates cell aggregation by homophilic binding .
8816929	0	tyrosine	55,63	ARK	71,74	tyrosine	ARK	CHEBI:18186	26362(Tax:10090)	Chemical	Gene	form|nmod|START_ENTITY Cleavage|nmod|form kinase|nsubj|Cleavage kinase|dobj|END_ENTITY	Cleavage and release of a soluble form of the receptor tyrosine kinase ARK in vitro and in vivo .
9395235	0	tyrosine	26,34	ARK	22,25	tyrosine	ARK	CHEBI:18186	26362(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Signaling through the ARK tyrosine kinase receptor protects from apoptosis in the absence of growth stimulation .
19287004	0	tyrosine	36,44	ASK1	99,103	tyrosine	ASK1	CHEBI:18186	26408(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	JAK2 and SHP2 reciprocally regulate tyrosine phosphorylation and stability of proapoptotic protein ASK1 .
7507323	0	tyrosine	8,16	AT2	113,116	tyrosine	AT2	CHEBI:18186	24182(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|receptor receptor|appos|END_ENTITY	Protein tyrosine phosphatase inhibition by angiotensin_II in rat pheochromocytoma cells through type 2 receptor , AT2 .
19126665	0	tyrosine	142,150	AXL	116,119	tyrosine	AXL	CHEBI:18186	26362(Tax:10090)	Chemical	Gene	kinases|compound|START_ENTITY subfamily|nmod|kinases subfamily|compound|END_ENTITY	Chronic angiotensin-converting enzyme inhibition up-regulates mouse kidney growth_arrest_specific-6 protein and the AXL subfamily of receptor tyrosine kinases .
21814748	0	tyrosine	31,39	AXL	47,50	tyrosine	AXL	CHEBI:18186	558	Chemical	Gene	Identification|nmod|START_ENTITY kinase|nsubj|Identification kinase|dobj|END_ENTITY	Identification of the receptor tyrosine kinase AXL in breast_cancer as a target for the human miR-34a microRNA .
23527720	0	tyrosine	26,34	AXL	13,16	tyrosine	AXL	CHEBI:18186	558	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Knockdown of AXL receptor tyrosine kinase in osteosarcoma cells leads to decreased proliferation and increased apoptosis .
24218367	0	tyrosine	21,29	AXL	75,78	tyrosine	AXL	CHEBI:18186	558	Chemical	Gene	identifies|nsubj|START_ENTITY identifies|dobj|role role|nmod|END_ENTITY	Comparative receptor tyrosine kinase profiling identifies a novel role for AXL in human stem cell pluripotency .
24681018	0	tyrosine	13,21	AXL	0,3	tyrosine	AXL	CHEBI:18186	558	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	AXL receptor tyrosine kinase is increased in patients with heart_failure .
26475093	0	tyrosine	25,33	AXL	41,44	tyrosine	AXL	D014443	558	Chemical	Gene	Coexpression|nmod|START_ENTITY kinase|nsubj|Coexpression kinase|dobj|END_ENTITY	Coexpression of receptor tyrosine kinase AXL and EGFR in human primary_lung_adenocarcinomas .
19217428	0	tyrosine	30,38	Abelson	22,29	tyrosine	Abelson	CHEBI:18186	45821(Tax:7227)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Interactions with the Abelson tyrosine kinase reveal compartmentalization of eyes absent function between nucleus and cytoplasm .
20024108	0	tyrosine	27,35	Abelson	19,26	tyrosine	Abelson	CHEBI:18186	25	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Rapid synthesis of Abelson tyrosine kinase inhibitors using click chemistry .
22988030	0	tyrosine	8,16	Abelson	0,7	tyrosine	Abelson	D014443	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Abelson tyrosine kinase controls phagosomal acidification required for killing of Mycobacterium_tuberculosis in human macrophages .
23175629	0	tyrosine	12,20	Abelson	4,11	tyrosine	Abelson	CHEBI:18186	45821(Tax:7227)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The Abelson tyrosine kinase regulates Notch endocytosis and signaling to maintain neuronal cell fate in Drosophila photoreceptors .
8647396	0	tyrosine	58,66	Abelson	44,51	tyrosine	Abelson	CHEBI:18186	45821(Tax:7227)	Chemical	Gene	START_ENTITY|nsubj|interactions interactions|nmod|END_ENTITY	Genetic interactions between the Drosophila Abelson -LRB- Abl -RRB- tyrosine kinase and failed axon connections -LRB- fax -RRB- , a novel protein in axon bundles .
11494134	0	tyrosine	45,53	Abl	41,44	tyrosine	Abl	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Regulation of Cbl phosphorylation by the Abl tyrosine kinase and the Nck SH2/SH3 adaptor .
11891774	0	tyrosine	57,65	Abl	53,56	tyrosine	Abl	CHEBI:18186	311860(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|interacts interacts|nmod|END_ENTITY	Brain armadillo protein delta-catenin interacts with Abl tyrosine kinase and modulates cellular morphogenesis in response to growth factors .
12626632	0	tyrosine	23,31	Abl	0,3	tyrosine	Abl	CHEBI:18186	11350(Tax:10090)	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Abl family nonreceptor tyrosine kinases modulate short-term synaptic plasticity .
15250677	0	tyrosine	80,88	Abl	96,99	tyrosine	Abl	CHEBI:18186	25	Chemical	Gene	inhibitor|nmod|START_ENTITY imatinib_mesylate|appos|inhibitor Use|nmod|imatinib_mesylate kinase|nsubj|Use kinase|dobj|transcript transcript|compound|END_ENTITY	Use and limitations of imatinib_mesylate -LRB- Glivec -RRB- , a selective inhibitor of the tyrosine kinase Abl transcript in the treatment of chronic_myeloid_leukaemia .
15456825	0	tyrosine	4,12	Abl	0,3	tyrosine	Abl	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Abl tyrosine kinase promotes dendrogenesis by inducing actin cytoskeletal rearrangements in cooperation with Rho family small GTPases in hippocampal neurons .
15917667	0	tyrosine	26,34	Abl	22,25	tyrosine	Abl	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Enabling death by the Abl tyrosine kinase : mechanisms for nuclear shuttling of c-Abl in response to DNA damage .
15975902	0	tyrosine	4,12	Abl	0,3	tyrosine	Abl	CHEBI:18186	45821(Tax:7227)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Abl tyrosine kinase and its substrate Ena/VASP have functional interactions with kinesin-1 .
16076903	0	tyrosine	4,12	Abl	0,3	tyrosine	Abl	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Abl tyrosine kinase regulates a Rac/JNK and a Rac/Nox pathway for DNA synthesis and Myc expression induced by growth factors .
16158058	0	tyrosine	95,103	Abl	91,94	tyrosine	Abl	CHEBI:18186	25	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Rb plays a role in survival of Abl-dependent human tumor cells as a downstream effector of Abl tyrosine kinase .
16943190	0	tyrosine	4,12	Abl	0,3	tyrosine	Abl	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Abl tyrosine kinase regulates endocytosis of the epidermal_growth_factor_receptor .
17382019	0	tyrosine	51,59	Abl	47,50	tyrosine	Abl	CHEBI:18186	25	Chemical	Gene	START_ENTITY|nsubj|issues issues|nmod|END_ENTITY	Emerging safety issues with imatinib and other Abl tyrosine kinase inhibitors .
17686996	0	tyrosine	4,12	Abl	0,3	tyrosine	Abl	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Abl tyrosine kinase promotes dorsal ruffles but restrains lamellipodia extension during cell spreading on fibronectin .
18078752	0	tyrosine	65,73	Abl	61,64	tyrosine	Abl	CHEBI:18186	25	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Discovery and SAR of 1,3,4-thiadiazole derivatives as potent Abl tyrosine kinase inhibitors and cytodifferentiating agents .
18160268	0	tyrosine	21,29	Abl	61,64	tyrosine	Abl	CHEBI:18186	45821(Tax:7227)	Chemical	Gene	phosphatase|nsubj|START_ENTITY phosphatase|ccomp|antagonizes antagonizes|dobj|kinase kinase|compound|END_ENTITY	The receptor protein tyrosine phosphatase PTP69D antagonizes Abl tyrosine kinase to guide axons in Drosophila .
18160268	0	tyrosine	65,73	Abl	61,64	tyrosine	Abl	CHEBI:18186	45821(Tax:7227)	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	The receptor protein tyrosine phosphatase PTP69D antagonizes Abl tyrosine kinase to guide axons in Drosophila .
18235247	0	tyrosine	4,12	Abl	0,3	tyrosine	Abl	CHEBI:18186	25	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Abl tyrosine kinases modulate cadherin-dependent adhesion upstream and downstream of Rho family GTPases .
18827006	1	tyrosine	104,112	Abl	93,96	tyrosine	Abl	CHEBI:18186	25	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Previously , we showed that Abl family tyrosine kinases are activated by growth factors , and Abl is required for transition from G1 to S phase during PDGF-mediated proliferation .
19290927	0	tyrosine	4,12	Abl	0,3	tyrosine	Abl	CHEBI:18186	11350(Tax:10090)	Chemical	Gene	kinases|amod|START_ENTITY END_ENTITY|dobj|kinases	Abl tyrosine kinases in T-cell signaling .
19326384	0	tyrosine	58,66	Abl	54,57	tyrosine	Abl	CHEBI:18186	25	Chemical	Gene	START_ENTITY|nsubj|models models|acl|built built|nmod|alignments alignments|nmod|END_ENTITY	3D QSAR models built on structure-based alignments of Abl tyrosine kinase inhibitors .
19768693	0	tyrosine	126,134	Abl	122,125	tyrosine	Abl	CHEBI:18186	25	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Dynamic change of T315I BCR-ABL kinase domain mutation in Korean chronic_myeloid_leukaemia patients during treatment with Abl tyrosine kinase inhibitors .
20181697	0	tyrosine	11,19	Abl	0,3	tyrosine	Abl	CHEBI:18186	25	Chemical	Gene	kinases|compound|START_ENTITY regulate|nsubj|kinases END_ENTITY|ccomp|regulate	Abl family tyrosine kinases regulate sialylated ganglioside receptors for polyomavirus .
20598684	2	tyrosine	339,347	Abl	304,307	tyrosine	Abl	CHEBI:18186	25	Chemical	Gene	phosphorylation|nmod|START_ENTITY END_ENTITY|dobj|phosphorylation	We previously demonstrated that Abl kinase activity is , itself , regulated by Abi1 subsequent to Abl kinase phosphorylation of Abi1 tyrosine 213 -LRB- pY213 -RRB- -LSB- 1 -RSB- .
20980600	0	tyrosine	11,19	Abl	0,3	tyrosine	Abl	CHEBI:18186	11350(Tax:10090)	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Abl family tyrosine kinases are essential for basement membrane integrity and cortical lamination in the cerebellum .
21602891	0	tyrosine	26,34	Abl	82,85	tyrosine	Abl	CHEBI:18186	25	Chemical	Gene	251|amod|START_ENTITY Crk|nmod|251 Phosphorylation|nmod|Crk promotes|nsubj|Phosphorylation promotes|dobj|transactivation transactivation|compound|END_ENTITY	Phosphorylation of Crk on tyrosine 251 in the RT loop of the SH3C domain promotes Abl kinase transactivation .
22033461	0	tyrosine	59,67	Abl	55,58	tyrosine	Abl	CHEBI:18186	25	Chemical	Gene	START_ENTITY|nsubj|Synthesis Synthesis|nmod|END_ENTITY	Synthesis and docking study of 2-phenylaminopyrimidine Abl tyrosine kinase inhibitors .
22340496	0	tyrosine	69,77	Abl	0,3	tyrosine	Abl	CHEBI:18186	45821(Tax:7227)	Chemical	Gene	phosphorylation|compound|START_ENTITY polarized|nmod|phosphorylation regulates|ccomp|polarized regulates|nsubj|END_ENTITY	Abl regulates planar polarized junctional dynamics through b-catenin tyrosine phosphorylation .
22493660	0	tyrosine	118,126	Abl	114,117	tyrosine	Abl	CHEBI:18186	25	Chemical	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	Structural and spectroscopic analysis of the kinase inhibitor bosutinib and an isomer of bosutinib binding to the Abl tyrosine kinase domain .
8453272	0	tyrosine	4,12	Abl	0,3	tyrosine	Abl	CHEBI:18186	11350(Tax:10090)	Chemical	Gene	kinase|amod|START_ENTITY END_ENTITY|dobj|kinase	Abl tyrosine kinase in signal transduction and cell-cycle regulation .
8520030	0	tyrosine	4,12	Abl	0,3	tyrosine	Abl	CHEBI:18186	25	Chemical	Gene	kinase|amod|START_ENTITY END_ENTITY|dobj|kinase	Abl tyrosine protein kinase .
8647396	0	tyrosine	58,66	Abl	53,56	tyrosine	Abl	CHEBI:18186	45821(Tax:7227)	Chemical	Gene	START_ENTITY|nsubj|interactions interactions|appos|END_ENTITY	Genetic interactions between the Drosophila Abelson -LRB- Abl -RRB- tyrosine kinase and failed axon connections -LRB- fax -RRB- , a novel protein in axon bundles .
9988744	0	tyrosine	49,57	Abl	45,48	tyrosine	Abl	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Engineering the substrate specificity of the Abl tyrosine kinase .
23598197	0	tyrosine	14,22	Abl1	9,13	tyrosine	Abl1	CHEBI:18186	25	Chemical	Gene	START_ENTITY|nsubj|Study Study|nmod|END_ENTITY	Study of Abl1 tyrosine kinase inhibitors by liquid chromatography-electrospray ionization-mass spectrometry .
24333704	0	tyrosine	120,128	Abl1	115,119	tyrosine	Abl1	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Development and validation of an indirect pulsed electrochemical detection method for monitoring the inhibition of Abl1 tyrosine kinase .
20432460	0	tyrosine	46,54	Ack1	41,45	tyrosine	Ack1	CHEBI:18186	10188	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Shepherding AKT and androgen_receptor by Ack1 tyrosine kinase .
20623637	0	tyrosine	15,23	Ack1	10,14	tyrosine	Ack1	CHEBI:18186	10188	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of Ack1 tyrosine kinase inhibitor on ligand-independent androgen_receptor activity .
12485851	0	tyrosine	47,55	Akt	25,28	tyrosine	Akt	CHEBI:18186	207	Chemical	Gene	kinase|compound|START_ENTITY END_ENTITY|nmod|kinase	alpha-Thrombin activates Akt via a nonreceptor tyrosine kinase in IIC9 cells .
24276246	0	tyrosine	112,120	Akt	108,111	tyrosine	Akt	CHEBI:18186	207	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Phosphatidylethanolamine-binding_protein_4 is associated with breast_cancer metastasis through Src-mediated Akt tyrosine phosphorylation .
14523446	0	tyrosine	43,51	Alk	59,62	tyrosine	Alk	CHEBI:18186	53425(Tax:7227)	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|dobj|END_ENTITY	Jelly_belly protein activates the receptor tyrosine kinase Alk to specify visceral muscle pioneers .
14523447	0	tyrosine	37,45	Alk	24,27	tyrosine	Alk	CHEBI:18186	53425(Tax:7227)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Jeb signals through the Alk receptor tyrosine kinase to drive visceral muscle fusion .
23827083	0	tyrosine	40,48	Alr5068	0,7	tyrosine	Alr5068	CHEBI:18186	1108672(Tax:103690)	Chemical	Gene	phosphatase|compound|START_ENTITY END_ENTITY|appos|phosphatase	Alr5068 , a Low-Molecular-Weight protein tyrosine phosphatase , is involved in formation of the heterocysts polysaccharide layer in the cyanobacterium Anabaena_sp .
7679104	0	tyrosine	21,29	Amphiregulin	0,12	tyrosine	Amphiregulin	CHEBI:18186	374	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Amphiregulin induces tyrosine phosphorylation of the epidermal_growth_factor_receptor and p185erbB2 .
22079349	0	tyrosine	41,49	Anaplastic_lymphoma_kinase	0,26	tyrosine	Anaplastic lymphoma kinase	CHEBI:18186	53425(Tax:7227)	Chemical	Gene	kinase|amod|START_ENTITY kinase|amod|END_ENTITY	Anaplastic_lymphoma_kinase and leukocyte tyrosine kinase : functions and genetic interactions in learning , memory and adult neurogenesis .
17158338	0	tyrosine	40,48	Angiotensin_II	0,14	tyrosine	Angiotensin II	CHEBI:18186	183	Chemical	Gene	release|amod|START_ENTITY induces|dobj|release induces|nsubj|END_ENTITY	Angiotensin_II induces soluble fms-Like tyrosine kinase-1 release via calcineurin signaling pathway in pregnancy .
2015108	0	tyrosine	31,39	Angiotensin_II	0,14	tyrosine	Angiotensin II	CHEBI:18186	183	Chemical	Gene	augmentation|nmod|START_ENTITY augmentation|compound|END_ENTITY	Angiotensin_II augmentation of tyrosine kinase activity in human adherent mononuclear cells .
7575404	0	tyrosine	23,31	Angiotensin_II	0,14	tyrosine	Angiotensin II	CHEBI:18186	24179(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Angiotensin_II induces tyrosine phosphorylation of insulin_receptor_substrate_1 and its association with phosphatidylinositol 3-kinase in rat heart .
7876204	0	tyrosine	26,34	Angiotensin_II	0,14	tyrosine	Angiotensin II	CHEBI:18186	24179(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates tyrosine phosphorylation of the focal adhesion-associated protein paxillin in aortic smooth muscle cells .
7953293	0	tyrosine	34,42	Angiotensin_II	0,14	tyrosine	Angiotensin II	CHEBI:18186	24179(Tax:10116)	Chemical	Gene	activity|compound|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates protein tyrosine phosphatase activity through a G-protein independent mechanism .
8144678	0	tyrosine	26,34	Angiotensin_II	0,14	tyrosine	Angiotensin II	CHEBI:18186	24179(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates tyrosine phosphorylation of phospholipase_C-gamma_1 in vascular smooth muscle cells .
9139682	0	tyrosine	26,34	Angiotensin_II	0,14	tyrosine	Angiotensin II	CHEBI:18186	24179(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates tyrosine phosphorylation and activation of insulin_receptor_substrate_1 and protein-tyrosine_phosphatase_1D in vascular smooth muscle cells .
9314836	0	tyrosine	26,34	Angiotensin_II	0,14	tyrosine	Angiotensin II	CHEBI:18186	11606(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates tyrosine phosphorylation of phospholipase C-gamma-associated proteins .
10528229	0	tyrosine	91,99	Axl	87,90	tyrosine	Axl	CHEBI:18186	558	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Noninsulin-dependent_diabetes_mellitus occurs in mice ectopically expressing the human Axl tyrosine kinase receptor .
11677117	0	tyrosine	13,21	Axl	0,3	tyrosine	Axl	CHEBI:18186	558	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Axl receptor tyrosine kinase expression in human lung_cancer cell lines correlates with cellular adhesion .
12796028	0	tyrosine	59,67	Axl	76,79	tyrosine	Axl	CHEBI:18186	558	Chemical	Gene	Coexpression|nmod|START_ENTITY kinases|nsubj|Coexpression kinases|dobj|END_ENTITY	Coexpression of growth_arrest-specific_gene_6 and receptor tyrosine kinases Axl and Sky in human uterine endometrial_cancers .
14561812	0	tyrosine	84,92	Axl	101,104	tyrosine	Axl	CHEBI:18186	558	Chemical	Gene	coexpression|nmod|START_ENTITY implications|nmod|coexpression kinases|nsubj|implications kinases|dobj|END_ENTITY	Clinical implications of coexpression of growth_arrest-specific_gene_6 and receptor tyrosine kinases Axl and Sky in human uterine_leiomyoma .
14729616	0	tyrosine	27,35	Axl	43,46	tyrosine	Axl	CHEBI:18186	558	Chemical	Gene	Expression|nmod|START_ENTITY kinase|nsubj|Expression kinase|ccomp|promotes promotes|nsubj|END_ENTITY	Expression of the receptor tyrosine kinase Axl promotes ocular_melanoma cell survival .
15964779	0	tyrosine	67,75	Axl	46,49	tyrosine	Axl	CHEBI:18186	558	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	The Ran binding protein RanBPM interacts with Axl and Sky receptor tyrosine kinases .
16585512	0	tyrosine	49,57	Axl	36,39	tyrosine	Axl	CHEBI:18186	26362(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Dominant-negative inhibition of the Axl receptor tyrosine kinase suppresses brain_tumor cell growth and invasion and prolongs survival .
16737840	0	tyrosine	73,81	Axl	47,50	tyrosine	Axl	CHEBI:18186	558	Chemical	Gene	subfamily|nmod|START_ENTITY subfamily|compound|END_ENTITY	Signalling and functional diversity within the Axl subfamily of receptor tyrosine kinases .
17064312	0	tyrosine	69,77	Axl	56,59	tyrosine	Axl	CHEBI:18186	558	Chemical	Gene	subfamily|compound|START_ENTITY subfamily|compound|END_ENTITY	Gas6 and protein S. Vitamin_K-dependent ligands for the Axl receptor tyrosine kinase subfamily .
19252414	0	tyrosine	17,25	Axl	4,7	tyrosine	Axl	CHEBI:18186	558	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The Axl receptor tyrosine kinase confers an adverse prognostic influence in pancreatic_cancer and represents a new therapeutic target .
19463168	0	tyrosine	107,115	Axl	94,97	tyrosine	Axl	CHEBI:18186	26362(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	AP-2alpha regulates migration of GN-11 neurons via a specific genetic programme involving the Axl receptor tyrosine kinase .
19815557	0	tyrosine	52,60	Axl	121,124	tyrosine	Axl	CHEBI:18186	558	Chemical	Gene	kinases|compound|START_ENTITY interaction|nmod|kinases mediated|nsubjpass|interaction mediated|nmod|Grb2 Grb2|dep|analysis analysis|nmod|effects effects|nmod|signaling signaling|compound|END_ENTITY	Cytoplasmic ACK1 interaction with multiple receptor tyrosine kinases is mediated by Grb2 : an analysis of ACK1 effects on Axl signaling .
20818175	0	tyrosine	17,25	Axl	4,7	tyrosine	Axl	CHEBI:18186	558	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The Axl receptor tyrosine kinase is an adverse prognostic factor and a therapeutic target in esophageal_adenocarcinoma .
20922806	0	tyrosine	27,35	Axl	43,46	tyrosine	Axl	CHEBI:18186	558	Chemical	Gene	Overexpression|nmod|START_ENTITY kinase|nsubj|Overexpression kinase|ccomp|promotes promotes|nsubj|END_ENTITY	Overexpression of receptor tyrosine kinase Axl promotes tumor cell invasion and survival in pancreatic_ductal_adenocarcinoma .
21317930	0	tyrosine	27,35	Axl	14,17	tyrosine	Axl	CHEBI:18186	558	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Regulation of Axl receptor tyrosine kinase expression by miR-34a and miR-199a / b in solid cancer .
21501828	0	tyrosine	94,102	Axl	110,113	tyrosine	Axl	CHEBI:18186	558	Chemical	Gene	phosphatidylserine|nmod|START_ENTITY kinase|nsubj|phosphatidylserine kinase|dobj|END_ENTITY	The soluble serum protein Gas6 bridges virion envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry .
21569627	0	tyrosine	21,29	Axl	37,40	tyrosine	Axl	CHEBI:18186	26362(Tax:10090)	Chemical	Gene	Loss|nmod|START_ENTITY kinase|nsubj|Loss kinase|ccomp|leads leads|nsubj|END_ENTITY	Loss of the receptor tyrosine kinase Axl leads to enhanced inflammation in the CNS and delayed removal of myelin_debris during experimental_autoimmune_encephalomyelitis .
22410775	0	tyrosine	13,21	Axl	29,32	tyrosine	Axl	CHEBI:18186	558	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|ccomp|regulator regulator|nsubj|END_ENTITY	The receptor tyrosine kinase Axl is an essential regulator of prostate_cancer proliferation and tumor growth and represents a new therapeutic target .
23226259	0	tyrosine	58,66	Axl	45,48	tyrosine	Axl	CHEBI:18186	26362(Tax:10090)	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Glycoxidised LDL induced the upregulation of Axl receptor tyrosine kinase and its ligand in mouse mesangial cells .
23321254	0	tyrosine	27,35	Axl	156,159	tyrosine	Axl	CHEBI:18186	558	Chemical	Gene	Inhibition|nmod|START_ENTITY kinase|nsubj|Inhibition kinase|ccomp|impedes impedes|dobj|activation activation|dep|implications implications|nmod|END_ENTITY	Inhibition of the receptor tyrosine kinase Axl impedes activation of the FLT3 internal tandem duplication in human acute_myeloid_leukemia : implications for Axl as a potential therapeutic target .
23321254	0	tyrosine	27,35	Axl	43,46	tyrosine	Axl	CHEBI:18186	558	Chemical	Gene	Inhibition|nmod|START_ENTITY kinase|nsubj|Inhibition kinase|ccomp|impedes impedes|nsubj|END_ENTITY	Inhibition of the receptor tyrosine kinase Axl impedes activation of the FLT3 internal tandem duplication in human acute_myeloid_leukemia : implications for Axl as a potential therapeutic target .
23361052	0	tyrosine	31,39	Axl	18,21	tyrosine	Axl	CHEBI:18186	558	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	The expression of Axl receptor tyrosine kinase influences the tumour phenotype and clinical outcome of patients with malignant_pleural_mesothelioma .
23754286	0	tyrosine	25,33	Axl	42,45	tyrosine	Axl	CHEBI:18186	558	Chemical	Gene	kinases|nsubj|START_ENTITY kinases|ccomp|endothelial endothelial|nsubj|END_ENTITY	Lactate engages receptor tyrosine kinases Axl , Tie2 , and vascular endothelial growth factor receptor 2 to activate phosphoinositide 3-kinase/Akt and promote angiogenesis .
24056961	0	tyrosine	13,21	Axl	29,32	tyrosine	Axl	CHEBI:18186	30126(Tax:7955)	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|ccomp|regulates regulates|nsubj|END_ENTITY	The receptor tyrosine kinase Axl regulates cell-cell adhesion and stemness in cutaneous_squamous_cell_carcinoma .
24862757	0	tyrosine	69,77	Axl	56,59	tyrosine	Axl	CHEBI:18186	558	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Activation of HER3 interferes with antitumor effects of Axl receptor tyrosine kinase inhibitors : suggestion of combination therapy .
24904064	0	tyrosine	13,21	Axl	0,3	tyrosine	Axl	CHEBI:18186	558	Chemical	Gene	START_ENTITY|nsubj|receptor receptor|compound|END_ENTITY	Axl receptor tyrosine kinase expression in breast_cancer .
24926787	0	tyrosine	13,21	Axl	0,3	tyrosine	Axl	CHEBI:18186	558	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Axl receptor tyrosine kinase is a novel target of apigenin for the inhibition of cell proliferation .
25019319	0	tyrosine	4,12	Axl	0,3	tyrosine	Axl	CHEBI:18186	26362(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Axl tyrosine kinase protects against tubulo-interstitial apoptosis and progression of renal_failure in a murine model of chronic_kidney_disease and hyperphosphataemia .
25403570	0	tyrosine	25,33	Axl	13,16	tyrosine	Axl	CHEBI:18186	26362(Tax:10090)	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Mice lacking Axl and Mer tyrosine kinase receptors are susceptible to experimental_autoimmune_orchitis induction .
25544427	0	tyrosine	67,75	Axl	44,47	tyrosine	Axl	CHEBI:18186	558	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Inhibition of IL-6 / STAT3 axis and targeting Axl and Tyro3 receptor tyrosine kinases by apigenin circumvent taxol resistance in ovarian_cancer cells .
25603826	0	tyrosine	17,25	Axl	4,7	tyrosine	Axl	D014443	26362(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The Axl receptor tyrosine kinase is a discriminator of macrophage function in the inflamed lung .
25783548	0	tyrosine	38,46	Axl	63,66	tyrosine	Axl	CHEBI:18186	558	Chemical	Gene	receptor|amod|START_ENTITY form|nmod|receptor Identification|nmod|form END_ENTITY|nsubj|Identification	Identification of the soluble form of tyrosine kinase receptor Axl as a potential biomarker for intracranial_aneurysm_rupture .
25820812	0	tyrosine	57,65	Axl	44,47	tyrosine	Axl	D014443	26362(Tax:10090)	Chemical	Gene	modulates|compound|START_ENTITY modulates|compound|END_ENTITY	Feedback regulation of IFN-a/b signaling by Axl receptor tyrosine kinase modulates HBV immunity .
25885003	0	tyrosine	38,46	Axl	63,66	tyrosine	Axl	D014443	558	Chemical	Gene	receptor|amod|START_ENTITY form|nmod|receptor Identification|nmod|form END_ENTITY|nsubj|Identification	Identification of the soluble form of tyrosine kinase receptor Axl as a potential biomarker for intracranial_aneurysm_rupture .
25975389	0	tyrosine	41,49	Axl	18,21	tyrosine	Axl	D014443	558	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Metformin targets Axl and Tyro3 receptor tyrosine kinases to inhibit cell proliferation and overcome chemoresistance in ovarian_cancer cells .
25980499	0	tyrosine	42,50	Axl	29,32	tyrosine	Axl	D014443	558	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Small molecule inhibition of Axl receptor tyrosine kinase potently suppresses multiple malignant properties of glioma cells .
25980499	0	tyrosine	42,50	Axl	29,32	tyrosine	Axl	D014443	558	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Small molecule inhibition of Axl receptor tyrosine kinase potently suppresses multiple malignant properties of glioma cells .
26036314	0	tyrosine	13,21	Axl	0,3	tyrosine	Axl	D014443	558	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Axl receptor tyrosine kinase is up-regulated in metformin resistant prostate_cancer cells .
26180925	0	tyrosine	13,21	Axl	0,3	tyrosine	Axl	D014443	558	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Axl receptor tyrosine kinase is a potential therapeutic target in renal_cell_carcinoma .
26257061	0	tyrosine	97,105	Axl	84,87	tyrosine	Axl	D014443	558	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Biodegradable interstitial release polymer loading a novel small molecule targeting Axl receptor tyrosine kinase and reducing brain_tumour migration and invasion .
26498137	0	tyrosine	48,56	Axl	35,38	tyrosine	Axl	D014443	558	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Curcumin-induced downregulation of Axl receptor tyrosine kinase inhibits cell proliferation and circumvents chemoresistance in non-small lung_cancer cells .
27048336	0	tyrosine	21,29	Axl	37,40	tyrosine	Axl	D014443	558	Chemical	Gene	Role|nmod|START_ENTITY kinase|nsubj|Role kinase|dobj|END_ENTITY	Role of the receptor tyrosine kinase Axl and its targeting in cancer cells .
7822279	0	tyrosine	26,34	Axl	43,46	tyrosine	Axl	CHEBI:18186	558	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	The transforming receptor tyrosine kinase , Axl , is post-translationally regulated by proteolytic cleavage .
7854420	0	tyrosine	13,21	Axl	0,3	tyrosine	Axl	CHEBI:18186	558	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Axl receptor tyrosine kinase stimulated by the vitamin_K-dependent protein encoded by growth-arrest-specific gene 6 .
7867073	0	tyrosine	111,119	Axl	88,91	tyrosine	Axl	CHEBI:18186	558	Chemical	Gene	kinases|compound|START_ENTITY family|nmod|kinases family|compound|END_ENTITY	The anticoagulation factor protein S and its relative , Gas6 , are ligands for the Tyro_3 / Axl family of receptor tyrosine kinases .
8524290	0	tyrosine	164,172	Axl	151,154	tyrosine	Axl	CHEBI:18186	558	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Differential activation of the Ras/extracellular-signal-regulated _ protein_kinase pathway is responsible for the biological consequences induced by the Axl receptor tyrosine kinase .
8637702	0	tyrosine	24,32	Axl	20,23	tyrosine	Axl	CHEBI:18186	26362(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Gas6 , the ligand of Axl tyrosine kinase receptor , has mitogenic and survival activities for serum starved NIH3T3 fibroblasts .
8939948	0	tyrosine	113,121	Axl	86,89	tyrosine	Axl	CHEBI:18186	308444(Tax:10116)	Chemical	Gene	START_ENTITY|amod|growth_arrest-specific_gene_6 growth_arrest-specific_gene_6|nmod|ligand ligand|nmod|END_ENTITY	Identification of the product of growth_arrest-specific_gene_6 as a common ligand for Axl , Sky , and Mer receptor tyrosine kinases .
9326369	0	tyrosine	90,98	Axl	86,89	tyrosine	Axl	CHEBI:18186	558	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	The product of a gas6 splice variant allows the release of the domain responsible for Axl tyrosine kinase receptor activation .
9758639	0	tyrosine	28,36	Axl	24,27	tyrosine	Axl	CHEBI:18186	308444(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Increased expression of Axl tyrosine kinase after vascular_injury and regulation by G protein-coupled receptor agonists in rats .
10085099	0	tyrosine	35,43	B-4	67,70	tyrosine	B-4	CHEBI:18186	930	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Cripto-1 indirectly stimulates the tyrosine phosphorylation of erb B-4 through a novel receptor .
8576157	1	tyrosine	91,99	B7-1_and_B7-2	63,76	tyrosine	B7-1 and B7-2	CHEBI:18186	941;942	Chemical	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	B7-1_and_B7-2 regulation of tyrosine kinase adaptor molecules .
21047529	0	tyrosine	51,59	BCAR-1	18,24	tyrosine	BCAR-1	CHEBI:18186	9564	Chemical	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification of BCAR-1 as a new substrate of Syk tyrosine kinase through a determination of amino_acid sequence preferences surrounding the substrate tyrosine residue .
10766197	0	tyrosine	8,16	BCR-ABL	0,7	tyrosine	BCR-ABL	CHEBI:18186	25	Chemical	Gene	activity|amod|START_ENTITY activity|nummod|END_ENTITY	BCR-ABL tyrosine kinase activity regulates the expression of multiple genes implicated in the pathogenesis of chronic_myeloid_leukemia .
10942235	0	tyrosine	72,80	BCR-ABL	54,61	tyrosine	BCR-ABL	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Increase in mutant frequencies in mice expressing the BCR-ABL activated tyrosine kinase .
11905636	0	tyrosine	36,44	BCR-ABL	28,35	tyrosine	BCR-ABL	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	STI571 : an inhibitor of the BCR-ABL tyrosine kinase for the treatment of chronic_myelogenous_leukaemia .
15171550	0	tyrosine	53,61	BCR-ABL	45,52	tyrosine	BCR-ABL	CHEBI:18186	25	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|amod|END_ENTITY	-LSB- Molecular design and biological activity of BCR-ABL tyrosine kinase inhibitors -RSB- .
16757427	0	tyrosine	33,41	BCR-ABL	25,32	tyrosine	BCR-ABL	CHEBI:18186	25	Chemical	Gene	START_ENTITY|nsubj|generation generation|nmod|END_ENTITY	The second generation of BCR-ABL tyrosine kinase inhibitors .
20537386	0	tyrosine	8,16	BCR-ABL	0,7	tyrosine	BCR-ABL	CHEBI:18186	25	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	BCR-ABL tyrosine kinase inhibitors in the treatment of Philadelphia_chromosome_positive_chronic_myeloid_leukemia : a review .
22005133	0	tyrosine	45,53	BCR-ABL	37,44	tyrosine	BCR-ABL	CHEBI:18186	25	Chemical	Gene	mutations|compound|START_ENTITY mutations|amod|END_ENTITY	Additional_chromosome_abnormalities , BCR-ABL tyrosine kinase domain mutations and clinical outcome in Hungarian tyrosine kinase inhibitor-resistant chronic_myelogenous_leukemia patients .
25382104	0	tyrosine	24,32	BCR-ABL	83,90	tyrosine	BCR-ABL	CHEBI:18186	25	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Identification of novel tyrosine kinase inhibitors for drug resistant T315I mutant BCR-ABL : a virtual screening and molecular_dynamics_simulations study .
26632460	0	tyrosine	60,68	BCR-ABL	52,59	tyrosine	BCR-ABL	D014443	25	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- A multicenter comparison study on the detection of BCR-ABL tyrosine kinase domain point mutation -RSB- .
8423987	0	tyrosine	8,16	BCR-ABL	0,7	tyrosine	BCR-ABL	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	BCR-ABL tyrosine kinase is autophosphorylated or transphosphorylates P160 BCR on tyrosine predominantly within the first BCR exon .
9000132	0	tyrosine	12,20	BCR-ABL	4,11	tyrosine	BCR-ABL	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	The BCR-ABL tyrosine kinase inhibits apoptosis by activating a Ras-dependent signaling pathway .
9858222	0	tyrosine	108,116	BCR-ABL	136,143	tyrosine	BCR-ABL	CHEBI:18186	25	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	The susceptibility of Philadelphia chromosome positive cells to FAS-mediated apoptosis is not linked to the tyrosine kinase activity of BCR-ABL .
10833515	0	tyrosine	12,20	BCR/ABL	4,11	tyrosine	BCR/ABL	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The BCR/ABL tyrosine kinase induces production of reactive_oxygen_species in hematopoietic cells .
11721366	0	tyrosine	41,49	BCR/ABL	25,32	tyrosine	BCR/ABL	CHEBI:18186	25;613	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	-LSB- Effects of As2O3 on the BCR/ABL protein tyrosine phosphorylation in K562 cells -RSB- .
20425353	0	tyrosine	53,61	BCR/ABL	45,52	tyrosine	BCR/ABL	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Genomic instability : The cause and effect of BCR/ABL tyrosine kinase .
8481400	0	tyrosine	62,70	BCR/ABL	46,53	tyrosine	BCR/ABL	CHEBI:18186	25;613	Chemical	Gene	kinases|compound|START_ENTITY kinases|amod|END_ENTITY	Comparison of baculovirus-expressed c-Abl and BCR/ABL protein tyrosine kinases .
21471444	0	tyrosine	4,12	BMX	20,23	tyrosine	BMX	CHEBI:18186	660	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|ccomp|mediator mediator|nsubj|END_ENTITY	The tyrosine kinase BMX is an essential mediator of inflammatory_arthritis in a kinase-independent manner .
23716717	0	tyrosine	110,118	BMX	16,19	tyrosine	BMX	CHEBI:18186	12169(Tax:10090)	Chemical	Gene	kinases|compound|START_ENTITY activation|nmod|kinases mediating|dobj|activation motif|acl|mediating phosphorylates|dobj|motif phosphorylates|nsubj|END_ENTITY	Tyrosine kinase BMX phosphorylates phosphotyrosine-primed motif mediating the activation of multiple receptor tyrosine kinases .
23847373	0	tyrosine	37,45	BMX	0,3	tyrosine	BMX	CHEBI:18186	660	Chemical	Gene	kinases|amod|START_ENTITY phosphorylation|nmod|kinases promotes|dobj|phosphorylation promotes|nsubj|END_ENTITY	BMX promotes dual phosphorylation of tyrosine kinases .
8790141	0	tyrosine	4,12	BMX	0,3	tyrosine	BMX	CHEBI:18186	660	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	BMX tyrosine kinase gene is expressed in granulocytes and myeloid_leukaemias .
11114724	0	tyrosine	22,30	BRK	18,21	tyrosine	BRK	CHEBI:18186	5753	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Expression of the BRK tyrosine kinase in mammary epithelial cells enhances the coupling of EGF signalling to PI 3-kinase and Akt , via erbB3 phosphorylation .
15509496	0	tyrosine	44,52	BRK	60,63	tyrosine	BRK	CHEBI:18186	5753	Chemical	Gene	expression|nmod|START_ENTITY kinase|nsubj|expression kinase|dobj|END_ENTITY	Differential expression of the non-receptor tyrosine kinase BRK in oral_squamous_cell_carcinoma and normal oral epithelium .
16855388	0	tyrosine	8,16	BRK	4,7	tyrosine	BRK	CHEBI:18186	5753	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The BRK tyrosine kinase is expressed in high-grade serous carcinoma_of_the_ovary .
11102316	0	tyrosine	7,15	BTK	24,27	tyrosine	BTK	CHEBI:18186	695	Chemical	Gene	START_ENTITY|dobj|kinase kinase|appos|END_ENTITY	Bruton tyrosine kinase -LRB- BTK -RRB- in X-linked_agammaglobulinemia -LRB- XLA -RRB- .
19343496	0	tyrosine	59,67	Bak	23,26	tyrosine	Bak	CHEBI:18186	578	Chemical	Gene	START_ENTITY|nsubj|loss loss|nmod|END_ENTITY	The additional loss of Bak and not the lack of the protein tyrosine kinase p56/Lck in one JCaM1 .6 subclone caused pronounced apoptosis resistance in response to stimuli of the intrinsic pathway .
12518171	0	tyrosine	144,152	Bcl-2	172,177	tyrosine	Bcl-2	CHEBI:18186	596	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	H1-A extracted from Cordyceps sinensis suppresses the proliferation of human mesangial cells and promotes apoptosis , probably by inhibiting the tyrosine phosphorylation of Bcl-2 and Bcl-XL .
16099425	0	tyrosine	53,61	Bcl-3	14,19	tyrosine	Bcl-3	CHEBI:18186	602	Chemical	Gene	interaction|nmod|START_ENTITY END_ENTITY|nmod|interaction	Regulation of Bcl-3 through interaction with the Lck tyrosine kinase .
10779439	0	tyrosine	135,143	Bcr-Abl	127,134	tyrosine	Bcr-Abl	CHEBI:18186	25	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Analysis of the biologic properties of p230 Bcr-Abl reveals unique and overlapping properties with the oncogenic p185 and p210 Bcr-Abl tyrosine kinases .
11114726	0	tyrosine	16,24	Bcr-Abl	0,7	tyrosine	Bcr-Abl	CHEBI:18186	25	Chemical	Gene	START_ENTITY|nsubj|protein protein|compound|END_ENTITY	Bcr-Abl protein tyrosine kinase activity induces a loss of p53 protein that mediates a delay in myeloid differentiation .
12488463	0	tyrosine	62,70	Bcr-Abl	54,61	tyrosine	Bcr-Abl	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Changes in the proteome associated with the action of Bcr-Abl tyrosine kinase are not related to transcriptional regulation .
12592324	0	tyrosine	31,39	Bcr-Abl	23,30	tyrosine	Bcr-Abl	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	The interaction of the Bcr-Abl tyrosine kinase with the Src kinase Hck is mediated by multiple binding domains .
15226183	0	tyrosine	34,42	Bcr-Abl	26,33	tyrosine	Bcr-Abl	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Chlorogenic_acid inhibits Bcr-Abl tyrosine kinase and triggers p38_mitogen-activated_protein_kinase-dependent apoptosis in chronic myelogenous leukemic cells .
18514829	0	tyrosine	178,186	Bcr-Abl	170,177	tyrosine	Bcr-Abl	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	PHA-680626 exhibits anti-proliferative and pro-apoptotic activity on Imatinib-resistant chronic_myeloid_leukemia cell lines and primary CD34 + cells by inhibition of both Bcr-Abl tyrosine kinase and Aurora kinases .
20072840	0	tyrosine	99,107	Bcr-Abl	91,98	tyrosine	Bcr-Abl	CHEBI:18186	25	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	Danusertib -LRB- formerly PHA-739358 -RRB- -- a novel combined pan-Aurora kinases and third generation Bcr-Abl tyrosine kinase inhibitor .
23787070	0	tyrosine	8,16	Bcr-Abl	0,7	tyrosine	Bcr-Abl	CHEBI:18186	25	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Bcr-Abl tyrosine kinase inhibitors - current status .
9393877	0	tyrosine	12,20	Bcr-Abl	4,11	tyrosine	Bcr-Abl	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	The Bcr-Abl tyrosine kinase activates mitogenic signaling pathways and stimulates G1-to-S phase transition in hematopoietic cells .
9671309	0	tyrosine	60,68	Bcr-Abl	52,59	tyrosine	Bcr-Abl	CHEBI:18186	25	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Protein kinase CK2alpha is a target for the Abl and Bcr-Abl tyrosine kinases .
10887132	0	tyrosine	116,124	Bcr/Abl	108,115	tyrosine	Bcr/Abl	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The Grb2 binding site is required for the induction of chronic_myeloid_leukemia-like disease in mice by the Bcr/Abl tyrosine kinase .
22721004	1	tyrosine	269,277	Bcr/Abl	261,268	tyrosine	Bcr/Abl	CHEBI:18186	25;613	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	BACKGROUND : Treatment of Philadelphia_chromosome-positive_acute_lymphoblastic_leukemias -LRB- Ph-positive_ALL -RRB- with clinically approved inhibitors of the Bcr/Abl tyrosine kinase frequently results in the emergence of a leukemic clone carrying the T315I mutation in Bcr/Abl , which confers resistance to these drugs .
15699036	0	tyrosine	6,14	Beta3	0,5	tyrosine	Beta3	CHEBI:18186	1934	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Beta3 tyrosine phosphorylation and alphavbeta3-mediated adhesion are required for Vav1 association and Rho activation in leukocytes .
7519620	0	tyrosine	34,42	Beta_2	0,6	tyrosine	Beta 2	CHEBI:18186	10242	Chemical	Gene	START_ENTITY|nsubj|protein protein|amod|END_ENTITY	Beta_2 integrin-dependent protein tyrosine phosphorylation and activation of the FGR protein tyrosine kinase in human neutrophils .
7525608	0	tyrosine	26,34	Beta_2	0,6	tyrosine	Beta 2	CHEBI:18186	10242	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Beta_2 integrin-dependent tyrosine phosphorylation of paxillin in human neutrophils treated with tumor necrosis factor .
10449731	0	tyrosine	29,37	Blk	45,48	tyrosine	Blk	CHEBI:18186	640	Chemical	Gene	Regulation|nmod|START_ENTITY kinase|nsubj|Regulation kinase|dobj|END_ENTITY	Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination .
2037301	0	tyrosine	40,48	Blk	57,60	tyrosine	Blk	CHEBI:18186	12143(Tax:10090)	Chemical	Gene	gene|nmod|START_ENTITY mapping|nmod|gene mapping|amod|END_ENTITY	Genetic mapping of the gene for a novel tyrosine kinase , Blk , to mouse chromosome 14 .
9636152	0	tyrosine	91,99	Blk	87,90	tyrosine	Blk	CHEBI:18186	12143(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Malignant transformation of early lymphoid progenitors in mice expressing an activated Blk tyrosine kinase .
10224128	0	tyrosine	59,67	Bmx	76,79	tyrosine	Bmx	CHEBI:18186	660	Chemical	Gene	signaling|nmod|START_ENTITY Btk|acl|signaling Reconstitution|nmod|Btk kinases|nsubj|Reconstitution kinases|dobj|END_ENTITY	Reconstitution of Btk signaling by the atypical tec family tyrosine kinases Bmx and Txk .
10962576	0	tyrosine	8,16	Bmx	4,7	tyrosine	Bmx	CHEBI:18186	660	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The Bmx tyrosine kinase is activated by IL-3 and G-CSF in a PI-3K dependent manner .
11416142	0	tyrosine	4,12	Bmx	0,3	tyrosine	Bmx	CHEBI:18186	12169(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Bmx tyrosine kinase has a redundant function downstream of angiopoietin and vascular endothelial growth factor receptors in arterial endothelium .
15191890	0	tyrosine	47,55	Bmx	0,3	tyrosine	Bmx	CHEBI:18186	660	Chemical	Gene	kinases|compound|START_ENTITY family|nmod|kinases member|nmod|family END_ENTITY|appos|member	Bmx , a member of the Tec family of nonreceptor tyrosine kinases , is a novel participant in pharmacological cardioprotection .
15229285	0	tyrosine	4,12	Bmx	0,3	tyrosine	Bmx	CHEBI:18186	12169(Tax:10090)	Chemical	Gene	transgene|compound|START_ENTITY transgene|compound|END_ENTITY	Bmx tyrosine kinase transgene induces skin_hyperplasia , inflammatory angiogenesis , and accelerated wound healing .
18025155	0	tyrosine	4,12	Bmx	0,3	tyrosine	Bmx	CHEBI:18186	660	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Bmx tyrosine kinase regulates TLR4-induced IL-6 production in human macrophages independently of p38 MAPK and NFkapp -RCB- B activity .
18988895	0	tyrosine	24,32	Bmx	8,11	tyrosine	Bmx	CHEBI:18186	12169(Tax:10090)	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Loss of Bmx nonreceptor tyrosine kinase prevents pressure overload-induced cardiac_hypertrophy .
21861773	0	tyrosine	75,83	Bmx	70,73	tyrosine	Bmx	CHEBI:18186	367786(Tax:10116)	Chemical	Gene	kinase|amod|START_ENTITY ETK|amod|kinase ETK|appos|END_ENTITY	Ligand-independent activation of the arylhydrocarbon receptor by ETK -LRB- Bmx -RRB- tyrosine kinase helps MCF10AT1 breast_cancer cells to survive in an apoptosis-inducing environment .
22593188	0	tyrosine	32,40	Bmx	28,31	tyrosine	Bmx	CHEBI:18186	12169(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Deletion of the endothelial Bmx tyrosine kinase decreases tumor angiogenesis and growth .
26430242	0	tyrosine	16,24	Bmx	12,15	tyrosine	Bmx	D014443	12169(Tax:10090)	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Endothelial Bmx tyrosine kinase activity is essential for myocardial_hypertrophy and remodeling .
9323053	0	tyrosine	4,12	Bmx	0,3	tyrosine	Bmx	CHEBI:18186	660	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Bmx tyrosine kinase is specifically expressed in the endocardium and the endothelium of large arteries .
9373245	0	tyrosine	8,16	Bmx	4,7	tyrosine	Bmx	CHEBI:18186	660	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The Bmx tyrosine kinase induces activation of the Stat signaling pathway , which is specifically inhibited by protein kinase Cdelta .
7539258	0	tyrosine	19,27	Bradykinin	0,10	tyrosine	Bradykinin	CHEBI:18186	3827	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Bradykinin induces tyrosine phosphorylation of epidermal_growth_factor-receptor and focal adhesion proteins in human keratinocytes .
8665918	0	tyrosine	19,27	Bradykinin	0,10	tyrosine	Bradykinin	CHEBI:18186	3827	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Bradykinin induces tyrosine phosphorylation in human foreskin fibroblasts and 293 cells transfected with rat B2 kinin receptor .
9600070	0	tyrosine	26,34	Bradykinin	0,10	tyrosine	Bradykinin	CHEBI:18186	3827	Chemical	Gene	phosphorylation|amod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Bradykinin stimulates the tyrosine phosphorylation and bradykinin B2_receptor association of phospholipase_C_gamma_1 in vascular endothelial cells .
10381539	0	tyrosine	66,74	Brain-derived_neurotrophic_factor	0,33	tyrosine	Brain-derived neurotrophic factor	CHEBI:18186	24225(Tax:10116)	Chemical	Gene	PTP1D|compound|START_ENTITY association|nmod|PTP1D enhances|dobj|association enhances|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor enhances association of protein tyrosine phosphatase PTP1D with the NMDA receptor subunit NR2B in the cortical postsynaptic density .
12074588	0	tyrosine	97,105	Brain-derived_neurotrophic_factor	0,33	tyrosine	Brain-derived neurotrophic factor	CHEBI:18186	627	Chemical	Gene	receptor|compound|START_ENTITY protein|nmod|receptor interaction|nmod|protein promotes|dobj|interaction promotes|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor promotes interaction of the Nck2 adaptor protein with the TrkB tyrosine kinase receptor .
15519688	0	tyrosine	51,59	Brain-derived_neurotrophic_factor	0,33	tyrosine	Brain-derived neurotrophic factor	CHEBI:18186	627	Chemical	Gene	phosphorylation|amod|START_ENTITY enhances|dobj|phosphorylation enhances|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor acutely enhances tyrosine phosphorylation of the AMPA receptor subunit GluR1 via NMDA receptor-dependent mechanisms .
7644540	0	tyrosine	113,121	Brain-derived_neurotrophic_factor	0,33	tyrosine	Brain-derived neurotrophic factor	CHEBI:18186	627	Chemical	Gene	receptors|compound|START_ENTITY neurons|nmod|receptors enhances|nmod|neurons enhances|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor rapidly enhances synaptic transmission in hippocampal neurons via postsynaptic tyrosine kinase receptors .
12121988	0	tyrosine	30,38	Brk	46,49	tyrosine	Brk	CHEBI:18186	5753	Chemical	Gene	Regulation|nmod|START_ENTITY kinase|nsubj|Regulation kinase|dobj|END_ENTITY	Regulation of the nonreceptor tyrosine kinase Brk by autophosphorylation and by autoinhibition .
15075665	0	tyrosine	16,24	Brk	4,7	tyrosine	Brk	CHEBI:18186	5753	Chemical	Gene	START_ENTITY|nsubj|protein protein|compound|END_ENTITY	The Brk protein tyrosine kinase as a therapeutic target in cancer : opportunities and challenges .
15725417	0	tyrosine	28,36	Brn-3a	0,6	tyrosine	Brn-3a	CHEBI:18186	18996(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|increases increases|amod|END_ENTITY	Brn-3a deficiency increases tyrosine hydroxylase-immunoreactive neurons in the dorsal root ganglion .
8145300	0	tyrosine	69,77	Bsk	34,37	tyrosine	Bsk	CHEBI:18186	13839(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY END_ENTITY|appos|kinase	Isolation and characterization of Bsk , a growth factor receptor-like tyrosine kinase associated with the limbic system .
10224128	0	tyrosine	59,67	Btk	18,21	tyrosine	Btk	CHEBI:18186	695	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Reconstitution of Btk signaling by the atypical tec family tyrosine kinases Bmx and Txk .
10688651	0	tyrosine	18,26	Btk	7,10	tyrosine	Btk	CHEBI:18186	12229(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Etk , a Btk family tyrosine kinase , mediates cellular transformation by linking Src to STAT3 activation .
10903718	0	tyrosine	40,48	Btk	58,61	tyrosine	Btk	CHEBI:18186	12229(Tax:10090)	Chemical	Gene	kinases|amod|START_ENTITY kinases|appos|END_ENTITY	Redundant and opposing functions of two tyrosine kinases , Btk and Lyn , in mast cell activation .
17684099	0	tyrosine	8,16	Btk	4,7	tyrosine	Btk	CHEBI:18186	695	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinib .
18292575	0	tyrosine	22,30	Btk	11,14	tyrosine	Btk	CHEBI:18186	695	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Etk/BMX , a Btk family tyrosine kinase , and Mal contribute to the cross-talk between MyD88 and FAK pathways .
7530500	0	tyrosine	42,50	Btk	30,33	tyrosine	Btk	CHEBI:18186	695	Chemical	Gene	START_ENTITY|nsubj|Association Association|nmod|END_ENTITY	Association and activation of Btk and Tec tyrosine kinases by gp130 , a signal transducer of the interleukin-6 family of cytokines .
7696342	0	tyrosine	144,152	Btk	140,143	tyrosine	Btk	CHEBI:18186	367901(Tax:10116)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Purification of a major tyrosine kinase from RBL-2H3 cells phosphorylating Fc_epsilon_RI_gamma-cytoplasmic domain and identification as the Btk tyrosine kinase .
8520028	0	tyrosine	33,41	Btk	4,7	tyrosine	Btk	CHEBI:18186	695	Chemical	Gene	kinases|compound|START_ENTITY subfamily|nmod|kinases subfamily|compound|END_ENTITY	The Btk subfamily of cytoplasmic tyrosine kinases : structure , regulation and function .
24510275	0	tyrosine	6,14	C-Abl	0,5	tyrosine	C-Abl	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	C-Abl tyrosine kinase mediates neurotoxic prion peptide-induced neuronal_apoptosis via regulating mitochondrial homeostasis .
12580961	0	tyrosine	42,50	C-FMS	67,72	tyrosine	C-FMS	CHEBI:18186	1436	Chemical	Gene	kinases|compound|START_ENTITY analysis|nmod|kinases analysis|appos|C-KIT C-KIT|dep|END_ENTITY	Mutational analysis of class III receptor tyrosine kinases -LRB- C-KIT , C-FMS , FLT3 -RRB- in idiopathic_myelofibrosis .
12017324	0	tyrosine	30,38	C-KIT	14,19	tyrosine	C-KIT	CHEBI:18186	3815	Chemical	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of C-KIT and HER-2 tyrosine kinase receptors in poor-prognosis_breast_cancer .
12580961	0	tyrosine	42,50	C-KIT	60,65	tyrosine	C-KIT	CHEBI:18186	3815	Chemical	Gene	kinases|compound|START_ENTITY analysis|nmod|kinases analysis|appos|END_ENTITY	Mutational analysis of class III receptor tyrosine kinases -LRB- C-KIT , C-FMS , FLT3 -RRB- in idiopathic_myelofibrosis .
22109829	0	tyrosine	66,74	C-KIT	60,65	tyrosine	C-KIT	CHEBI:18186	3815	Chemical	Gene	START_ENTITY|csubj|Reactivating Reactivating|nmod|END_ENTITY	Reactivating PP2A by FTY720 as a novel therapy for AML with C-KIT tyrosine kinase domain mutation .
16320053	0	tyrosine	15,23	C-kit	0,5	tyrosine	C-kit	CHEBI:18186	3815	Chemical	Gene	START_ENTITY|nsubj|receptor receptor|amod|END_ENTITY	C-kit receptor tyrosine kinase -LRB- CD117 -RRB- expression and its positive predictive value for the diagnosis of Thai adult_acute_myeloid_leukemia .
16439366	0	tyrosine	73,81	C-terminal_Src_kinase	90,111	tyrosine	C-terminal Src kinase	CHEBI:18186	1445	Chemical	Gene	START_ENTITY|dobj|kinase kinase|appos|END_ENTITY	Docking-based substrate recognition by the catalytic domain of a protein tyrosine kinase , C-terminal_Src_kinase -LRB- Csk -RRB- .
16483606	0	tyrosine	62,70	C-terminal_Src_kinase	83,104	tyrosine	C-terminal Src kinase	CHEBI:18186	1445	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	Structural basis for domain-domain communication in a protein tyrosine kinase , the C-terminal_Src_kinase .
9878439	0	tyrosine	25,33	C-terminal_Src_kinase	51,72	tyrosine	C-terminal Src kinase	CHEBI:18186	1445	Chemical	Gene	START_ENTITY|dobj|domain domain|nmod|END_ENTITY	Structure of the protein tyrosine kinase domain of C-terminal_Src_kinase -LRB- CSK -RRB- in complex with staurosporine .
23401856	0	tyrosine	20,28	C1-Ten	0,6	tyrosine	C1-Ten	CHEBI:18186	23371	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|nsubj|END_ENTITY	C1-Ten is a protein tyrosine phosphatase of insulin_receptor_substrate_1 -LRB- IRS-1 -RRB- , regulating IRS-1 stability and muscle_atrophy .
20441772	0	tyrosine	42,50	CA1	114,117	tyrosine	CA1	CHEBI:18186	310218(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Oligomerized Abeta25-35 induces increased tyrosine phosphorylation of NMDA receptor subunit 2A in rat hippocampal CA1 subfield .
11820818	0	tyrosine	31,39	CABYR	0,5	tyrosine	CABYR	CHEBI:18186	26256	Chemical	Gene	protein|amod|START_ENTITY END_ENTITY|appos|protein	CABYR , a novel calcium-binding tyrosine phosphorylation-regulated fibrous sheath protein involved in capacitation .
16139264	0	tyrosine	202,210	CABYR	28,33	tyrosine	CABYR	CHEBI:18186	26256	Chemical	Gene	protein|acl:relcl|START_ENTITY protein|nsubj|Translation Translation|nmod|B B|amod|END_ENTITY	Translation and assembly of CABYR coding region B in fibrous sheath and restriction of calcium binding to coding region A. CABYR is a highly polymorphic , sperm flagellar calcium-binding protein that is tyrosine as well as serine/threonine phosphorylated during capacitation .
15944127	0	tyrosine	17,25	CAM-1	33,38	tyrosine	CAM-1	CHEBI:18186	174473(Tax:6239)	Chemical	Gene	START_ENTITY|ccomp|required required|nsubjpass|END_ENTITY	The Ror receptor tyrosine kinase CAM-1 is required for ACR-16-mediated synaptic transmission at the C. _ elegans neuromuscular junction .
17942487	0	tyrosine	28,36	CAM-1	45,50	tyrosine	CAM-1	CHEBI:18186	174473(Tax:6239)	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	The C. _ elegans ROR receptor tyrosine kinase , CAM-1 , non-autonomously inhibits the Wnt pathway .
12417328	0	tyrosine	59,67	CB2	75,78	tyrosine	CB2	CHEBI:18186	1269	Chemical	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	Absence of a conserved proline and presence of a conserved tyrosine in the CB2 cannabinoid receptor are crucial for its function .
20126411	0	tyrosine	89,97	CBL	0,3	tyrosine	CBL	D014443	867	Chemical	Gene	kinases|compound|START_ENTITY mutations|nmod|kinases relationship|acl|mutations lung_cancers|dep|relationship altered|nmod|lung_cancers altered|nsubjpass|END_ENTITY	CBL is frequently altered in lung_cancers : its relationship to mutations in MET and EGFR tyrosine kinases .
22246246	0	tyrosine	68,76	CBL	0,3	tyrosine	CBL	CHEBI:18186	867	Chemical	Gene	mutation-related|advcl|START_ENTITY mutation-related|nsubj|END_ENTITY	CBL mutation-related patterns of phosphorylation and sensitivity to tyrosine kinase inhibitors .
24886428	0	tyrosine	78,86	CBL	106,109	tyrosine	CBL	CHEBI:18186	867	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	A PKC-SHP1 signaling axis desensitizes Fcy receptor signaling by reducing the tyrosine phosphorylation of CBL and regulates FcyR mediated phagocytosis .
9129019	0	tyrosine	42,50	CBL	70,73	tyrosine	CBL	CHEBI:18186	12402(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Erythropoietin and interleukin-3 activate tyrosine phosphorylation of CBL and association with CRK adaptor proteins .
16320053	0	tyrosine	15,23	CD117	32,37	tyrosine	CD117	CHEBI:18186	3815	Chemical	Gene	START_ENTITY|dobj|expression expression|appos|END_ENTITY	C-kit receptor tyrosine kinase -LRB- CD117 -RRB- expression and its positive predictive value for the diagnosis of Thai adult_acute_myeloid_leukemia .
10706446	0	tyrosine	22,30	CD148	0,5	tyrosine	CD148	CHEBI:18186	5795	Chemical	Gene	phosphatase|compound|START_ENTITY END_ENTITY|appos|phosphatase	CD148 , a new membrane tyrosine phosphatase involved in leukocyte function .
12588999	0	tyrosine	18,26	CD148	40,45	tyrosine	CD148	CHEBI:18186	19271(Tax:10090)	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|appos|END_ENTITY	A mutant receptor tyrosine phosphatase , CD148 , causes defects_in_vascular_development .
12588999	2	tyrosine	279,287	CD148	301,306	tyrosine	CD148	CHEBI:18186	19271(Tax:10090)	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|appos|END_ENTITY	Here we evaluated whether an endothelium-expressed receptor tyrosine phosphatase , CD148 -LRB- DEP-1 / PTPeta -RRB- , participates in developmental vascularization .
25386896	0	tyrosine	6,14	CD148	0,5	tyrosine	CD148	CHEBI:18186	19271(Tax:10090)	Chemical	Gene	phosphatase|amod|START_ENTITY phosphatase|nummod|END_ENTITY	CD148 tyrosine phosphatase promotes cadherin cell adhesion .
9232433	0	tyrosine	26,34	CD148	0,5	tyrosine	CD148	CHEBI:18186	5795	Chemical	Gene	phosphatase|compound|START_ENTITY END_ENTITY|appos|phosphatase	CD148 , a membrane protein tyrosine phosphatase , is able to induce tyrosine phosphorylation on human lymphocytes .
10933394	0	tyrosine	34,42	CD19	0,4	tyrosine	CD19	CHEBI:18186	930	Chemical	Gene	regulates|ccomp|START_ENTITY regulates|nsubj|END_ENTITY	CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification .
9120258	0	tyrosine	21,29	CD19	49,53	tyrosine	CD19	CHEBI:18186	930	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Membrane IgM-induced tyrosine phosphorylation of CD19 requires a CD19 domain that mediates association with components of the B cell antigen receptor complex .
9200454	0	tyrosine	51,59	CD19	103,107	tyrosine	CD19	CHEBI:18186	930	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	CD38 ligation in human B cell progenitors triggers tyrosine phosphorylation of CD19 and association of CD19 with lyn and phosphatidylinositol_3-kinase .
9200454	0	tyrosine	51,59	CD19	79,83	tyrosine	CD19	CHEBI:18186	930	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	CD38 ligation in human B cell progenitors triggers tyrosine phosphorylation of CD19 and association of CD19 with lyn and phosphatidylinositol_3-kinase .
10228003	0	tyrosine	15,23	CD22	43,47	tyrosine	CD22	CHEBI:18186	933	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	CD45 regulates tyrosine phosphorylation of CD22 and its association with the protein tyrosine phosphatase SHP-1 .
10556805	0	tyrosine	16,24	CD28	0,4	tyrosine	CD28	CHEBI:18186	12487(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	CD28 stimulates tyrosine phosphorylation , cellular redistribution and catalytic activity of the inositol lipid 5-phosphatase SHIP .
10973911	0	tyrosine	96,104	CD28	91,95	tyrosine	CD28	CHEBI:18186	940	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	A molecular basis for T cell suppression by IL-10 : CD28-associated IL-10 receptor inhibits CD28 tyrosine phosphorylation and phosphatidylinositol 3-kinase binding .
9915850	0	tyrosine	64,72	CD28	92,96	tyrosine	CD28	CHEBI:18186	940	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	CD80 and CD86 are not equivalent in their ability to induce the tyrosine phosphorylation of CD28 .
10858437	0	tyrosine	68,76	CD31	96,100	tyrosine	CD31	CHEBI:18186	18613(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Collagen , convulxin , and thrombin stimulate aggregation-independent tyrosine phosphorylation of CD31 in platelets .
7875731	0	tyrosine	46,54	CD38	29,33	tyrosine	CD38	CHEBI:18186	12494(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|activation activation|nmod|END_ENTITY	Murine B-cell activation via CD38 and protein tyrosine phosphorylation .
7492777	0	tyrosine	15,23	CD43	0,4	tyrosine	CD43	CHEBI:18186	6693	Chemical	Gene	phosphorylation|amod|START_ENTITY regulates|dobj|phosphorylation regulates|nsubj|END_ENTITY	CD43 regulates tyrosine phosphorylation of a 93-kD protein in T lymphocytes .
9573028	0	tyrosine	59,67	CD44	0,4	tyrosine	CD44	CHEBI:18186	960	Chemical	Gene	associates|nmod|START_ENTITY associates|nummod|END_ENTITY	CD44 selectively associates with active Src family protein tyrosine kinases Lck and Fyn in glycosphingolipid-rich plasma membrane domains of human peripheral blood lymphocytes .
10228003	0	tyrosine	15,23	CD45	0,4	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	phosphorylation|amod|START_ENTITY regulates|dobj|phosphorylation regulates|nsubj|END_ENTITY	CD45 regulates tyrosine phosphorylation of CD22 and its association with the protein tyrosine phosphatase SHP-1 .
10415030	0	tyrosine	98,106	CD45	0,4	tyrosine	CD45	CHEBI:18186	19264(Tax:10090)	Chemical	Gene	residues|compound|START_ENTITY dephosphorylating|dobj|residues regulates|advcl|dephosphorylating regulates|nsubj|END_ENTITY	CD45 negatively regulates lyn activity by dephosphorylating both positive and negative regulatory tyrosine residues in immature B cells .
10458749	0	tyrosine	9,17	CD45	4,8	tyrosine	CD45	CHEBI:18186	19264(Tax:10090)	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|compound|END_ENTITY	The CD45 tyrosine phosphatase regulates CD3-induced signal transduction and T cell development in recombinase-deficient mice : restoration of pre-TCR function by active p56 -LRB- lck -RRB- .
10508267	0	tyrosine	89,97	CD45	84,88	tyrosine	CD45	CHEBI:18186	19264(Tax:10090)	Chemical	Gene	mice|amod|START_ENTITY mice|nummod|END_ENTITY	Greatly reduced efficiency of both positive and negative selection of thymocytes in CD45 tyrosine phosphatase-deficient mice .
10653852	0	tyrosine	85,93	CD45	72,76	tyrosine	CD45	CHEBI:18186	24699(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|cell cell|acl|signaling signaling|nmod|protein protein|compound|END_ENTITY	Regulation of mast cell signaling through high-affinity IgE receptor by CD45 protein tyrosine phosphatase .
10683443	0	tyrosine	86,94	CD45	73,77	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	START_ENTITY|nsubj|interactions interactions|nmod|domains domains|nmod|protein protein|compound|END_ENTITY	Intra - and intermolecular interactions of the catalytic domains of human CD45 protein tyrosine phosphatase .
10700239	0	tyrosine	17,25	CD45	38,42	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	Mutations|nmod|START_ENTITY phosphatase|nsubj|Mutations phosphatase|dobj|gene gene|nummod|END_ENTITY	Mutations in the tyrosine phosphatase CD45 gene in a child with severe combined_immunodeficiency_disease .
10710209	0	tyrosine	38,46	CD45	33,37	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	START_ENTITY|nsubj|inhibition inhibition|nmod|END_ENTITY	HIV_type_1-induced inhibition of CD45 tyrosine phosphatase activity correlates with disease progression and apoptosis , but not with anti-CD3-induced T cell proliferation .
10744652	0	tyrosine	9,17	CD45	4,8	tyrosine	CD45	CHEBI:18186	19264(Tax:10090)	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|compound|END_ENTITY	The CD45 tyrosine phosphatase regulates Campath-1H -LRB- CD52 -RRB- - induced TCR-dependent signal transduction in human T cells .
10963676	0	tyrosine	32,40	CD45	27,31	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	START_ENTITY|nsubj|basis basis|nmod|END_ENTITY	A supramolecular basis for CD45 tyrosine phosphatase regulation in sustained T cell activation .
10970857	0	tyrosine	36,44	CD45	31,35	tyrosine	CD45	CHEBI:18186	19264(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Development Development|nmod|T-leukaemias T-leukaemias|nmod|END_ENTITY	Development of T-leukaemias in CD45 tyrosine phosphatase-deficient mutant lck mice .
10995582	0	tyrosine	9,17	CD45	4,8	tyrosine	CD45	CHEBI:18186	19264(Tax:10090)	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|compound|END_ENTITY	The CD45 tyrosine phosphatase : a positive and negative regulator of immune cell function .
10998263	0	tyrosine	47,55	CD45	68,72	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	evaluating|dobj|START_ENTITY method|acl|evaluating Development|nmod|method phosphatase|nsubj|Development phosphatase|dobj|inhibitors inhibitors|nummod|END_ENTITY	Development of a method for evaluating protein tyrosine phosphatase CD45 inhibitors using Jurkat cell membrane .
11241282	0	tyrosine	19,27	CD45	14,18	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	START_ENTITY|nsubj|Modulation Modulation|nmod|END_ENTITY	Modulation of CD45 tyrosine phosphatase activity by antigen .
11342620	0	tyrosine	5,13	CD45	0,4	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	phosphatase|amod|START_ENTITY phosphatase|nummod|END_ENTITY	CD45 tyrosine phosphatase controls common gamma-chain cytokine-mediated STAT and extracellular signal-related kinase phosphorylation in activated human lymphoblasts : inhibition of proliferation without induction of apoptosis .
11694532	0	tyrosine	109,117	CD45	28,32	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	kinase|compound|START_ENTITY pools|nmod|kinase actions|nmod|pools regulates|dobj|actions regulates|nsubj|association association|nmod|isoforms isoforms|nummod|END_ENTITY	Differential association of CD45 isoforms with CD4 and CD8 regulates the actions of specific pools of p56lck tyrosine kinase in T_cell_antigen_receptor signal transduction .
11913947	0	tyrosine	24,32	CD45	45,49	tyrosine	CD45	CHEBI:18186	19264(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY phosphatase|nsubj|role phosphatase|dobj|END_ENTITY	The role of the protein tyrosine phosphatase CD45 in regulation of B lymphocyte activation .
12008046	0	tyrosine	9,17	CD45	31,35	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	START_ENTITY|xcomp|phosphatase phosphatase|dep|galectin-1 galectin-1|nmod:npmod|binds binds|nummod|END_ENTITY	Receptor tyrosine phosphatase , CD45 binds galectin-1 but does not mediate its apoptotic signal in T cell lines .
12098278	0	tyrosine	61,69	CD45	48,52	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	START_ENTITY|nsubj|protein protein|compound|END_ENTITY	Efficient total synthesis of pulchellalactam , a CD45 protein tyrosine phosphatase inhibitor .
12393728	0	tyrosine	5,13	CD45	0,4	tyrosine	CD45	CHEBI:18186	19264(Tax:10090)	Chemical	Gene	phosphatase|amod|START_ENTITY phosphatase|nummod|END_ENTITY	CD45 tyrosine phosphatase inhibits erythroid differentiation of umbilical cord blood CD34 + cells associated with selective inactivation of Lyn .
12519755	0	tyrosine	124,132	CD45	146,150	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|appos|END_ENTITY	Differential regulation of CXCR4-mediated T-cell chemotaxis and mitogen-activated protein kinase activation by the membrane tyrosine phosphatase , CD45 .
12595907	0	tyrosine	23,31	CD45	44,48	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	77_C / G mutation in the tyrosine phosphatase CD45 gene and autoimmune hepatitis : evidence for a genetic link .
12633939	0	tyrosine	39,47	CD45	26,30	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	phosphatase|amod|START_ENTITY phosphatase|compound|END_ENTITY	Oxidative inactivation of CD45 protein tyrosine phosphatase may contribute to T lymphocyte dysfunction in the elderly .
1370625	0	tyrosine	46,54	CD45	33,37	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	phosphatases|compound|START_ENTITY phosphatases|compound|END_ENTITY	Catalytic domains of the LAR and CD45 protein tyrosine phosphatases from Escherichia_coli expression systems : purification and characterization for specificity and mechanism .
1370931	0	tyrosine	61,69	CD45	82,86	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	characterization|nmod|START_ENTITY phosphatase|nsubj|characterization phosphatase|dobj|END_ENTITY	Biochemical and functional characterization of the leucocyte tyrosine phosphatase CD45 -LRB- CD45RO , 180 kD -RRB- from human neutrophils .
1371471	0	tyrosine	92,100	CD45	0,4	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	phosphorylation|amod|START_ENTITY regulation|nmod|phosphorylation thymocytes|nmod|regulation activation|nmod|thymocytes modulates|dobj|activation modulates|nsubj|END_ENTITY	CD45 modulates T cell receptor/CD3-induced activation of human thymocytes via regulation of tyrosine phosphorylation .
1380977	0	tyrosine	9,17	CD45	4,8	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|compound|END_ENTITY	The CD45 tyrosine phosphatase regulates phosphotyrosine homeostasis and its loss reveals a novel pattern of late T cell receptor-induced Ca2 + oscillations .
1431097	0	tyrosine	20,28	CD45	121,125	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	phosphorylation|compound|START_ENTITY Regulation|nmod|phosphorylation Regulation|amod|complex complex|nmod|phosphatase phosphatase|appos|END_ENTITY	Regulation of basal tyrosine phosphorylation of the B cell antigen receptor complex by the protein tyrosine phosphatase , CD45 .
1431097	0	tyrosine	99,107	CD45	121,125	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|appos|END_ENTITY	Regulation of basal tyrosine phosphorylation of the B cell antigen receptor complex by the protein tyrosine phosphatase , CD45 .
1464315	0	tyrosine	5,13	CD45	0,4	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	p59fyn|amod|START_ENTITY p59fyn|nummod|END_ENTITY	CD45 tyrosine phosphatase-activated p59fyn couples the T cell antigen receptor to pathways of diacylglycerol production , protein kinase C activation and calcium influx .
14681989	0	tyrosine	21,29	CD45	42,46	tyrosine	CD45	D014443	5788	Chemical	Gene	Role|nmod|START_ENTITY phosphatase|nsubj|Role phosphatase|dobj|END_ENTITY	-LSB- Role of the protein tyrosine phosphatase CD45 in signal transduction of hematopoietic cells -RSB- .
14979481	0	tyrosine	12,20	CD45	33,37	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	phosphatase|nsubj|START_ENTITY phosphatase|ccomp|required required|nsubjpass|END_ENTITY	The protein tyrosine phosphatase CD45 is required for interleukin_6 signaling in U266 myeloma cells .
15065873	0	tyrosine	34,42	CD45	55,59	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	inactivation|nmod|START_ENTITY phosphatase|nsubj|inactivation phosphatase|dobj|END_ENTITY	Catalytic inactivation of protein tyrosine phosphatase CD45 and protein_tyrosine_phosphatase_1B by polyaromatic quinones .
1532148	0	tyrosine	114,122	CD45	109,113	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	phosphatase|amod|START_ENTITY phosphatase|compound|END_ENTITY	Interaction of CD4 : lck with the T cell receptor/CD3 complex induces early signaling events in the absence of CD45 tyrosine phosphatase .
1532394	0	tyrosine	37,45	CD45	32,36	tyrosine	CD45	CHEBI:18186	19264(Tax:10090)	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|compound|END_ENTITY	The alternative splicing of the CD45 tyrosine phosphatase is controlled by negative regulatory trans-acting splicing factors .
1533589	0	tyrosine	33,41	CD45	56,60	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	Regulation|nmod|START_ENTITY kinase|nsubj|Regulation kinase|nmod|phosphatase phosphatase|compound|END_ENTITY	Regulation of the p59fyn protein tyrosine kinase by the CD45 phosphotyrosine phosphatase .
15554922	0	tyrosine	73,81	CD45	33,37	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	activity|amod|START_ENTITY membrane-associated|dobj|activity membrane-associated|nsubj|crosslinking crosslinking|nmod|down-regulates down-regulates|nummod|END_ENTITY	Epitope-specific crosslinking of CD45 down-regulates membrane-associated tyrosine phosphatase activity and triggers early signalling events in human activated T cells .
15687496	0	tyrosine	49,57	CD45	14,18	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	domain|compound|START_ENTITY lacking|dobj|domain END_ENTITY|acl|lacking	Expression of CD45 lacking the catalytic protein tyrosine phosphatase domain modulates Lck phosphorylation and T cell activation .
15946252	0	tyrosine	82,90	CD45	51,55	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	START_ENTITY|nsubj|interacts interacts|nmod|protein protein|compound|END_ENTITY	Integrin CD11a cytoplasmic tail interacts with the CD45 membrane-proximal protein tyrosine phosphatase domain 1 .
15963758	0	tyrosine	25,33	CD45	46,50	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	START_ENTITY|dobj|gene gene|compound|END_ENTITY	C77G mutation in protein tyrosine phosphatase CD45 gene and autoimmune_hepatitis .
1652055	0	tyrosine	67,75	CD45	54,58	tyrosine	CD45	CHEBI:18186	19264(Tax:10090)	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|compound|END_ENTITY	CD8 + T-cell clones deficient in the expression of the CD45 protein tyrosine phosphatase have impaired responses to T-cell receptor stimuli .
1652760	0	tyrosine	67,75	CD45	29,33	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	cells|amod|START_ENTITY phosphorylated|nmod|cells phosphorylated|nsubjpass|END_ENTITY	Protein-tyrosine-phosphatase CD45 is phosphorylated transiently on tyrosine upon activation of Jurkat T cells .
1654595	0	tyrosine	36,44	CD45	23,27	tyrosine	CD45	CHEBI:18186	19264(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|protein protein|compound|END_ENTITY	Negative regulation of CD45 protein tyrosine phosphatase activity by ionomycin in T cells .
1672451	0	tyrosine	107,115	CD45	21,25	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	kinase|compound|START_ENTITY receptor|nmod|kinase required|nmod|receptor required|nsubjpass|END_ENTITY	Tyrosine phosphatase CD45 is required for T-cell antigen receptor and CD2-mediated activation of a protein tyrosine kinase and interleukin_2 production .
1682387	0	tyrosine	101,109	CD45	123,127	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	phosphatase|amod|START_ENTITY phosphatase|appos|END_ENTITY	Rapid increases in the membrane expression of neutral_endopeptidase -LRB- CD10 -RRB- , aminopeptidase_N -LRB- CD13 -RRB- , tyrosine phosphatase -LRB- CD45 -RRB- , and Fc_gamma-RIII -LRB- CD16 -RRB- upon stimulation of human peripheral leukocytes with human C5a .
17195233	0	tyrosine	75,83	CD45	70,74	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	phosphatase|amod|START_ENTITY phosphatase|nummod|END_ENTITY	Altered lipid raft-associated proximal signaling and translocation of CD45 tyrosine phosphatase in B lymphocytes from patients with systemic_lupus_erythematosus .
17277109	0	tyrosine	79,87	CD45	27,31	tyrosine	CD45	CHEBI:18186	19264(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY regulating|dobj|phosphorylation phosphatase|advcl|regulating phosphatase|nsubj|Changes Changes|nmod|role role|nmod|tyrosine tyrosine|compound|END_ENTITY	Changes in the role of the CD45 protein tyrosine phosphatase in regulating Lck tyrosine phosphorylation during thymic development .
1850360	2	tyrosine	285,293	CD45	338,342	tyrosine	CD45	CHEBI:18186	19264(Tax:10090)	Chemical	Gene	activity|compound|START_ENTITY exhibits|dep|activity called|nsubjpass|exhibits proteins|acl:relcl|called family|nmod|proteins END_ENTITY|nsubj|family	A family of leukocyte transmembrane proteins whose cytoplasmic domain exhibits intrinsic protein tyrosine phosphatase activity is collectively called CD45 and is identified by a set of common cell surface epitopes .
18941197	0	tyrosine	67,75	CD45	54,58	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|compound|END_ENTITY	Selective regulation of TCR signaling pathways by the CD45 protein tyrosine phosphatase during thymocyte development .
19683682	0	tyrosine	26,34	CD45	47,51	tyrosine	CD45	CHEBI:18186	19264(Tax:10090)	Chemical	Gene	levels|nmod|START_ENTITY phosphatase|nsubj|levels phosphatase|ccomp|protect protect|nsubj|END_ENTITY	Reduced levels of protein tyrosine phosphatase CD45 protect mice from the lethal effects of Ebola_virus_infection .
1976251	0	tyrosine	76,84	CD45	71,75	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|compound|END_ENTITY	Intimate association of Thy-1 and the T-cell_antigen_receptor with the CD45 tyrosine phosphatase .
19856105	0	tyrosine	15,23	CD45	36,40	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	Involvement|nmod|START_ENTITY phosphatase|nsubj|Involvement phosphatase|dobj|END_ENTITY	Involvement of tyrosine phosphatase CD45 in apoptosis .
19861160	0	tyrosine	61,69	CD45	83,87	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|appos|END_ENTITY	Modulation of immune cell signalling by the leukocyte common tyrosine phosphatase , CD45 .
21386843	0	tyrosine	145,153	CD45	22,26	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	inhibitors|amod|START_ENTITY treated|nmod|inhibitors patients|acl|treated outcome|nmod|patients correlate|nmod|outcome cells|amod|correlate VEGFR2|dobj|cells VEGFR2|nsubj|Levels Levels|nmod|CD34 CD34|compound|END_ENTITY	Levels of circulating CD45 -LRB- dim -RRB- CD34 -LRB- + -RRB- VEGFR2 -LRB- + -RRB- progenitor cells correlate with outcome in metastatic_renal_cell_carcinoma patients treated with tyrosine kinase inhibitors .
2141684	0	tyrosine	47,55	CD45	104,108	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	START_ENTITY|nmod|antigen antigen|appos|END_ENTITY	Dephosphorylation and activation of the T cell tyrosine kinase pp56lck by the leukocyte common antigen -LRB- CD45 -RRB- .
2162357	0	tyrosine	35,43	CD45	0,4	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	phosphatase|compound|START_ENTITY END_ENTITY|appos|phosphatase	CD45 , an integral membrane protein tyrosine phosphatase .
2170146	0	tyrosine	85,93	CD45	44,48	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|activation activation|nmod|expression expression|amod|protein_kinase_C protein_kinase_C|nmod|END_ENTITY	Effect of activation of protein_kinase_C on CD45 isoform expression and CD45 protein tyrosine phosphatase activity in T cells .
22174689	0	tyrosine	67,75	CD45	88,92	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	interacts|nmod|START_ENTITY interacts|amod|phosphatase phosphatase|dep|END_ENTITY	The human_cytomegalovirus UL11 protein interacts with the receptor tyrosine phosphatase CD45 , resulting in functional paralysis of T cells .
22438252	0	tyrosine	25,33	CD45	53,57	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	Mutation|nmod|START_ENTITY phosphatase|nsubj|Mutation phosphatase|dobj|PTPRC PTPRC|appos|END_ENTITY	Mutation of the receptor tyrosine phosphatase PTPRC -LRB- CD45 -RRB- in T-cell_acute_lymphoblastic_leukemia .
22891353	0	tyrosine	43,51	CD45	133,137	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	phosphatase|compound|START_ENTITY using|dobj|phosphatase screen|acl|using reveals|nsubj|screen reveals|dobj|inhibitors inhibitors|nmod|END_ENTITY	High-throughput screen using a single-cell tyrosine phosphatase assay reveals biologically active inhibitors of tyrosine phosphatase CD45 .
23524573	0	tyrosine	79,87	CD45	66,70	tyrosine	CD45	CHEBI:18186	19264(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|activation activation|nmod|regulation regulation|nmod|protein protein|compound|END_ENTITY	Astragaloside_II triggers T cell activation through regulation of CD45 protein tyrosine phosphatase activity .
2530588	0	tyrosine	61,69	CD45	14,18	tyrosine	CD45	CHEBI:18186	19264(Tax:10090)	Chemical	Gene	kinase|amod|START_ENTITY phosphorylation|nmod|kinase alters|dobj|phosphorylation alters|nsubj|Expression Expression|nmod|END_ENTITY	Expression of CD45 alters phosphorylation of the lck-encoded tyrosine protein kinase in murine lymphoma_T-cell_lines .
2548204	0	tyrosine	31,39	CD45	70,74	tyrosine	CD45	CHEBI:18186	19264(Tax:10090)	Chemical	Gene	protein|compound|START_ENTITY activation|nmod|protein kinase|nsubj|activation kinase|nmod|phosphatase phosphatase|compound|END_ENTITY	Rapid activation of the T-cell tyrosine protein kinase pp56lck by the CD45 phosphotyrosine phosphatase .
7499277	0	tyrosine	28,36	CD45	47,51	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	START_ENTITY|xcomp|kinase kinase|nmod|END_ENTITY	Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells .
7507203	0	tyrosine	112,120	CD45	28,32	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	kinase|compound|START_ENTITY creates|nmod|kinase creates|nsubj|phosphorylation phosphorylation|nmod|phosphatase phosphatase|nummod|END_ENTITY	Tyrosine phosphorylation of CD45 phosphotyrosine phosphatase by p50csk kinase creates a binding site for p56lck tyrosine kinase and activates the phosphatase .
7520448	0	tyrosine	126,134	CD45	121,125	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|compound|END_ENTITY	Induction of tyrosine phosphorylation during ICAM-3 and LFA-1-mediated intercellular adhesion , and its regulation by the CD45 tyrosine phosphatase .
7526153	0	tyrosine	5,13	CD45	0,4	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	activity|amod|START_ENTITY activity|nummod|END_ENTITY	CD45 tyrosine phosphatase activity and membrane anchoring are required for T-cell antigen receptor signaling .
7542629	0	tyrosine	16,24	CD45	85,89	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	kinases|amod|START_ENTITY Role|nmod|kinases Role|dep|END_ENTITY	Role of protein tyrosine kinases and phosphatases in isotype switching : crosslinking CD45 to CD40 inhibits IgE isotype switching in human B cells .
7594536	0	tyrosine	61,69	CD45	17,21	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	phosphorylation|compound|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|Cross-linking Cross-linking|nmod|END_ENTITY	Cross-linking of CD45 on NK cells stimulates p56lck-mediated tyrosine phosphorylation and IFN-gamma production .
7621884	0	tyrosine	118,126	CD45	30,34	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|nsubj|mutation mutation|nmod|gene gene|compound|END_ENTITY	A point mutation in the human CD45 gene associated with defective splicing of exon A. CD45 is a receptor-type protein tyrosine phosphatase involved in the regulation of lymphocyte activation .
7684415	0	tyrosine	18,26	CD45	90,94	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	adhesion|amod|START_ENTITY Regulation|nmod|adhesion pathway|nsubj|Regulation pathway|nmod|END_ENTITY	Regulation of the tyrosine kinase-dependent adhesion pathway in human lymphocytes through CD45 .
7693695	1	tyrosine	63,71	CD45	128,132	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	phosphorylation|amod|START_ENTITY Induction|nmod|phosphorylation mobilization|nsubj|Induction mobilization|dobj|independent independent|nmod|expression expression|compound|END_ENTITY	Induction of tyrosine phosphorylation and calcium mobilization independent of CD45 expression .
7705403	0	tyrosine	61,69	CD45	82,86	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	events|nmod|START_ENTITY Modulation|nmod|events phosphatase|nsubj|Modulation phosphatase|dobj|END_ENTITY	Modulation of Fc_gamma_receptor-mediated early events by the tyrosine phosphatase CD45 in primary human monocytes .
7737297	0	tyrosine	25,33	CD45	67,71	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	protein|compound|START_ENTITY Regulation|nmod|protein kinase|nsubj|Regulation kinase|nmod|phosphatase phosphatase|compound|END_ENTITY	Regulation of the p70zap tyrosine protein kinase in T cells by the CD45 phosphotyrosine phosphatase .
7807014	0	tyrosine	123,131	CD45	110,114	tyrosine	CD45	CHEBI:18186	19264(Tax:10090)	Chemical	Gene	mice|compound|START_ENTITY mice|compound|END_ENTITY	Impaired development of V gamma 3 dendritic_epidermal_T cells in p56lck protein tyrosine kinase-deficient and CD45 protein tyrosine phosphatase-deficient mice .
7818534	0	tyrosine	66,74	CD45	51,55	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	START_ENTITY|nsubj|mutation mutation|nmod|domain domain|nmod|abrogates abrogates|nummod|END_ENTITY	Point mutation in the second phosphatase domain of CD45 abrogates tyrosine phosphatase activity .
7875193	0	tyrosine	32,40	CD45	53,57	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	Characterization|nmod|START_ENTITY phosphatase|nsubj|Characterization phosphatase|dobj|END_ENTITY	Characterization of the protein tyrosine phosphatase CD45 on human epidermal Langerhans cells .
7897197	0	tyrosine	26,34	CD45	14,18	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	phosphorylation|amod|START_ENTITY Regulation|nmod|phosphorylation Regulation|nmod|END_ENTITY	Regulation by CD45 of the tyrosine phosphorylation of high affinity IgE receptor beta - and gamma-chains .
7961804	0	tyrosine	75,83	CD45	37,41	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	phosphatase|nsubj|START_ENTITY phosphatase|advcl|Mapping Mapping|dobj|domain domain|nmod|END_ENTITY	Mapping the fodrin binding domain in CD45 , a leukocyte membrane-associated tyrosine phosphatase .
8011300	0	tyrosine	36,44	CD45	0,4	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	phosphatase|compound|START_ENTITY role|nmod|phosphatase END_ENTITY|dep|role	CD45 : an emerging role as a protein tyrosine phosphatase required for lymphocyte activation and development .
8041724	0	tyrosine	43,51	CD45	38,42	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	phosphatase|amod|START_ENTITY phosphatase|compound|END_ENTITY	Engagement of the external domains of CD45 tyrosine phosphatase can regulate the differentiation of immature CD4 + CD8 + thymocytes into mature T cells .
8051172	0	tyrosine	7,15	CD45	24,28	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	START_ENTITY|dobj|kinase kinase|appos|END_ENTITY	ZAP-70 tyrosine kinase , CD45 , and T cell receptor involvement in UV - and H2O2-induced T cell signal transduction .
8051405	0	tyrosine	37,45	CD45	24,28	tyrosine	CD45	CHEBI:18186	19264(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Elevation Elevation|nmod|protein protein|compound|END_ENTITY	Elevation of lymphocyte CD45 protein tyrosine phosphatase activity during mitosis .
8168490	0	tyrosine	9,17	CD45	4,8	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|compound|END_ENTITY	The CD45 tyrosine phosphatase regulates specific pools of antigen receptor-associated p59fyn and CD4-associated p56lck tyrosine in human T-cells .
8175795	0	tyrosine	19,27	CD45	0,4	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	phosphorylation|amod|START_ENTITY regulation|nmod|phosphorylation regulation|nummod|END_ENTITY	CD45 regulation of tyrosine phosphorylation and enzyme activity of src family kinases .
8428589	0	tyrosine	100,108	CD45	0,4	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	encompassing|dobj|START_ENTITY phosphopeptide|acl|encompassing modulates|nmod|phosphopeptide modulates|nsubj|END_ENTITY	CD45 specifically modulates binding of Lck to a phosphopeptide encompassing the negative regulatory tyrosine of Lck .
8441403	0	tyrosine	47,55	CD45	42,46	tyrosine	CD45	CHEBI:18186	19264(Tax:10090)	Chemical	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Differential effects of expression of the CD45 tyrosine protein phosphatase on the tyrosine phosphorylation of the lck , fyn , and c-src tyrosine protein kinases .
8441403	0	tyrosine	83,91	CD45	42,46	tyrosine	CD45	CHEBI:18186	19264(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphatase|nmod|phosphorylation phosphatase|nsubj|effects effects|nmod|expression expression|nmod|protein protein|compound|END_ENTITY	Differential effects of expression of the CD45 tyrosine protein phosphatase on the tyrosine phosphorylation of the lck , fyn , and c-src tyrosine protein kinases .
8463207	0	tyrosine	25,33	CD45	98,102	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	START_ENTITY|nmod|second second|nmod|domains domains|nmod|END_ENTITY	Demonstration of protein tyrosine phosphatase activity in the second of two homologous domains of CD45 .
8703037	0	tyrosine	46,54	CD45	132,136	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	START_ENTITY|xcomp|Vav Vav|nmod|isoforms isoforms|nmod|phosphatase phosphatase|compound|END_ENTITY	Differential regulation of activation-induced tyrosine phosphorylation and recruitment of SLP-76 to Vav by distinct isoforms of the CD45 protein-tyrosine phosphatase .
8734787	0	tyrosine	80,88	CD45	152,156	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	pervanadate|amod|START_ENTITY signaling|nmod|pervanadate complex|acl|signaling Stimulation|nmod|complex mediated|nsubjpass|Stimulation mediated|nmod|inhibition inhibition|nmod|END_ENTITY	Stimulation of the T-cell antigen receptor-CD3 complex signaling pathway by the tyrosine phosphatase inhibitor pervanadate is mediated by inhibition of CD45 : evidence for two interconnected Lck/Fyn - or zap-70-dependent signaling pathways .
8766549	0	tyrosine	43,51	CD45	64,68	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	engagement|nmod|START_ENTITY phosphatase|nsubj|engagement phosphatase|ccomp|induces induces|nsubj|END_ENTITY	Epitope-specific engagement of the protein tyrosine phosphatase CD45 induces tumor_necrosis_factor-alpha gene expression via transcriptional mechanisms .
8947048	0	tyrosine	16,24	CD45	62,66	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	kinase|compound|START_ENTITY function|nsubj|kinase function|nmod|END_ENTITY	The Syk protein tyrosine kinase can function independently of CD45 or Lck in T_cell_antigen_receptor signaling .
9218819	0	tyrosine	16,24	CD45	58,62	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	START_ENTITY|dobj|activity activity|nmod|END_ENTITY	Reduced protein tyrosine phosphatase -LRB- PTPase -RRB- activity of CD45 on peripheral blood lymphocytes in patients with systemic_lupus_erythematosus -LRB- SLE -RRB- .
9581568	0	tyrosine	45,53	CD45	0,4	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	activities|compound|START_ENTITY display|dobj|activities display|nsubj|END_ENTITY	CD45 and RPTPalpha display different protein tyrosine phosphatase activities in T lymphocytes .
9725213	0	tyrosine	42,50	CD45	29,33	tyrosine	CD45	CHEBI:18186	19264(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|requirements requirements|nmod|protein protein|compound|END_ENTITY	Differential requirements of CD45 protein tyrosine phosphatase for cytolytic activities and intrathymic and extrathymic development of intestinal intraepithelial lymphocytes .
9837977	0	tyrosine	38,46	CD45	25,29	tyrosine	CD45	CHEBI:18186	5788	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|compound|END_ENTITY	The second domain of the CD45 protein tyrosine phosphatase is critical for interleukin-2 secretion and substrate recruitment of TCR-zeta in vivo .
9973453	0	tyrosine	23,31	CD45	18,22	tyrosine	CD45	CHEBI:18186	19264(Tax:10090)	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|compound|END_ENTITY	Cutting edge : the CD45 tyrosine phosphatase is an inhibitor of Lck activity in thymocytes .
9394826	0	tyrosine	16,24	CD6	70,73	tyrosine	CD6	CHEBI:18186	923	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Analysis of the tyrosine phosphorylation and calcium fluxing of human CD6 isoforms with different cytoplasmatic domains .
8871662	0	tyrosine	21,29	CD63	0,4	tyrosine	CD63	CHEBI:18186	967	Chemical	Gene	associates|nmod|START_ENTITY associates|nummod|END_ENTITY	CD63 associates with tyrosine kinase activity and CD11/CD18 , and transmits an activation signal in neutrophils .
8103709	0	tyrosine	24,32	CD69	54,58	tyrosine	CD69	CHEBI:18186	969	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|expression expression|compound|END_ENTITY	Differential effects of tyrosine kinase inhibition in CD69 antigen expression and lytic activity induced by rIL-2 , rIL-12 , and rIFN-alpha in human NK cells .
15149864	8	tyrosine	1437,1445	CDK1	1465,1469	tyrosine	CDK1	CHEBI:18186	983	Chemical	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	In addition , we found that wortmannin treatment inhibits dephosphorylation of the tyrosine inhibitory site of CDK1 .
8674031	10	tyrosine	1837,1845	CDK2	1832,1836	tyrosine	CDK2	CHEBI:18186	1017	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|compound|END_ENTITY	This increased immunoprecipitated kinase activity was dependent on the Flavopiridol concentration added to intact cells and was associated with a reduction of CDK2 tyrosine phosphorylation .
15380516	0	tyrosine	64,72	COX-2	38,43	tyrosine	COX-2	CHEBI:18186	4513	Chemical	Gene	promoter|nmod|START_ENTITY promoter|compound|END_ENTITY	Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2 .
25540073	0	tyrosine	85,93	CRKL	80,84	tyrosine	CRKL	CHEBI:18186	1399	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Integrative analysis of high-throughput RNAi screen data identifies the FER and CRKL tyrosine kinases as new regulators of the mitogenic ERK-dependent pathways in transformed cells .
9092574	0	tyrosine	21,29	CRKL	49,53	tyrosine	CRKL	CHEBI:18186	1399	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Steel_factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit , phosphatidylinositol 3-kinase , and p120 -LRB- CBL -RRB- .
9092574	0	tyrosine	21,29	CRKL	69,73	tyrosine	CRKL	CHEBI:18186	1399	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Steel_factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit , phosphatidylinositol 3-kinase , and p120 -LRB- CBL -RRB- .
16905744	0	tyrosine	15,23	CXCL12	0,6	tyrosine	CXCL12	CHEBI:18186	6387	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	CXCL12 induces tyrosine phosphorylation of cortactin , which plays a role in CXC_chemokine_receptor_4-mediated extracellular signal-regulated kinase activation and chemotaxis .
11585773	0	tyrosine	21,29	Cables	0,6	tyrosine	Cables	CHEBI:18186	91768	Chemical	Gene	phosphorylation|amod|START_ENTITY enhances|dobj|phosphorylation enhances|nsubj|END_ENTITY	Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1 , inhibits cell growth , and is lost in many human colon_and_squamous_cancers .
12752736	0	tyrosine	5,13	CagA	0,4	tyrosine	CagA	CHEBI:18186	6279	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	CagA tyrosine phosphorylation in gastric epithelial cells caused by Helicobacter_pylori in patients with gastric_adenocarcinoma .
11056155	0	tyrosine	18,26	Cas	14,17	tyrosine	Cas	CHEBI:18186	9564	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	G -LRB- i -RRB- - mediated Cas tyrosine phosphorylation in vascular endothelial cells stimulated with sphingosine_1-phosphate : possible involvement in cell motility enhancement in cooperation with Rho-mediated pathways .
19275884	0	tyrosine	15,23	Cas-L	43,48	tyrosine	Cas-L	CHEBI:18186	4739	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	SHP-2 inhibits tyrosine phosphorylation of Cas-L and regulates cell migration .
9497377	0	tyrosine	25,33	Cas-L	53,58	tyrosine	Cas-L	CHEBI:18186	4739	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	T cell receptor-mediated tyrosine phosphorylation of Cas-L , a 105-kDa Crk-associated substrate-related protein , and its association of Crk and C3G .
17190831	0	tyrosine	11,19	Caveolin-1	0,10	tyrosine	Caveolin-1	CHEBI:18186	857	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Caveolin-1 tyrosine phosphorylation enhances paclitaxel-mediated cytotoxicity .
10347229	1	tyrosine	130,138	Cbl	126,129	tyrosine	Cbl	CHEBI:18186	12402(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	A critical role for Cbl tyrosine kinase-binding domain .
10358153	0	tyrosine	37,45	Cbl	65,68	tyrosine	Cbl	CHEBI:18186	867	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Protein kinase C activation inhibits tyrosine phosphorylation of Cbl and its recruitment of Src homology 2 domain-containing proteins .
10540342	0	tyrosine	41,49	Cbl	69,72	tyrosine	Cbl	CHEBI:18186	100725041	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Role of Syk in Fc gamma receptor-coupled tyrosine phosphorylation of Cbl in a manner susceptible to inhibition by protein kinase C. Fcgamma receptors -LRB- FcgammaR -RRB- of guinea_pig neutrophils were ligated and anti-Cbl immunoprecipitates prepared therefrom were assayed for the associated protein tyrosine kinase activity , which increased upon ligation of FcgammaR .
10617633	0	tyrosine	78,86	Cbl	26,29	tyrosine	Cbl	CHEBI:18186	867	Chemical	Gene	kinase|compound|START_ENTITY regulation|nmod|kinase essential|nmod|regulation essential|nsubj|domain domain|nmod|END_ENTITY	The RING finger domain of Cbl is essential for negative regulation of the Syk tyrosine kinase .
10629042	0	tyrosine	67,75	Cbl	4,7	tyrosine	Cbl	CHEBI:18186	867	Chemical	Gene	Fyn|amod|START_ENTITY regulates|dobj|Fyn regulates|nsubj|product product|compound|END_ENTITY	The Cbl proto-oncogene product negatively regulates the Src-family tyrosine kinase Fyn by enhancing its degradation .
11042121	0	tyrosine	58,66	Cbl	86,89	tyrosine	Cbl	CHEBI:18186	867	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Platelet alpha IIb-beta 3 integrin engagement induces the tyrosine phosphorylation of Cbl and its association with phosphoinositide 3-kinase and Syk .
11283727	0	tyrosine	42,50	Cbl	0,3	tyrosine	Cbl	CHEBI:18186	867	Chemical	Gene	kinases|compound|START_ENTITY regulate|dobj|kinases adaptations|acl|regulate END_ENTITY|dep|adaptations	Cbl : many adaptations to regulate protein tyrosine kinases .
11494134	0	tyrosine	45,53	Cbl	14,17	tyrosine	Cbl	CHEBI:18186	867	Chemical	Gene	kinase|compound|START_ENTITY phosphorylation|nmod|kinase phosphorylation|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of Cbl phosphorylation by the Abl tyrosine kinase and the Nck SH2/SH3 adaptor .
11724969	0	tyrosine	58,66	Cbl	4,7	tyrosine	Cbl	CHEBI:18186	867	Chemical	Gene	kinases|amod|START_ENTITY signaling|nmod|kinases regulating|advcl|signaling ligases|acl|regulating family|dep|ligases family|compound|END_ENTITY	The Cbl family : ubiquitin ligases regulating signaling by tyrosine kinases .
11994499	0	tyrosine	69,77	Cbl	4,7	tyrosine	Cbl	CHEBI:18186	12402(Tax:10090)	Chemical	Gene	kinase|amod|START_ENTITY regulators|nmod|kinase family|dep|regulators family|compound|END_ENTITY	The Cbl family of ubiquitin ligases : critical negative regulators of tyrosine kinase signaling in the immune system .
16289966	0	tyrosine	111,119	Cbl	107,110	tyrosine	Cbl	CHEBI:18186	867	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Activation of Epstein-Barr_virus / C3d receptor -LRB- gp140 , CR2 , CD21 -RRB- on human B lymphoma cell surface triggers Cbl tyrosine phosphorylation , its association with p85 subunit , Crk-L and Syk and its dissociation with Vav .
17699773	0	tyrosine	39,47	Cbl	88,91	tyrosine	Cbl	CHEBI:18186	867	Chemical	Gene	exhibit|amod|START_ENTITY receptors|nmod|exhibit reduced|nsubj|receptors reduced|dobj|association association|compound|END_ENTITY	Epidermal growth factor receptors with tyrosine kinase domain mutations exhibit reduced Cbl association , poor ubiquitylation , and down-regulation but are efficiently internalized .
19419964	0	tyrosine	4,12	Cbl	114,117	tyrosine	Cbl	CHEBI:18186	867	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|function function|nmod|activity activity|nmod|END_ENTITY	Syk tyrosine 317 negatively regulates osteoclast function via the ubiquitin-protein isopeptide ligase activity of Cbl .
21129358	0	tyrosine	91,99	Cbl	74,77	tyrosine	Cbl	CHEBI:18186	867	Chemical	Gene	assay|dep|START_ENTITY assay|acl|identify identify|dobj|inhibitors inhibitors|nmod|END_ENTITY	High-throughput fluorescence polarization assay to identify inhibitors of Cbl -LRB- TKB -RRB- - protein tyrosine kinase interactions .
21655429	0	tyrosine	87,95	Cbl	33,36	tyrosine	Cbl	CHEBI:18186	12402(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY regulators|nmod|kinase proteins|nmod|regulators proteins|compound|END_ENTITY	Indispensable roles of mammalian Cbl family proteins as negative regulators of protein tyrosine kinase signaling : Insights from in vivo models .
8920860	0	tyrosine	24,32	Cbl	20,23	tyrosine	Cbl	CHEBI:18186	500985(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Characterization Characterization|nmod|END_ENTITY	Characterization of Cbl tyrosine phosphorylation and a Cbl-Syk complex in RBL-2H3 cells .
9400833	0	tyrosine	17,25	Cbl	45,48	tyrosine	Cbl	CHEBI:18186	867	Chemical	Gene	START_ENTITY|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Agonist-specific tyrosine phosphorylation of Cbl in human neutrophils .
9535867	0	tyrosine	30,38	Cbl	58,61	tyrosine	Cbl	CHEBI:18186	867	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases .
9535867	0	tyrosine	77,85	Cbl	58,61	tyrosine	Cbl	CHEBI:18186	867	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases .
9541596	0	tyrosine	93,101	Cbl	121,124	tyrosine	Cbl	CHEBI:18186	867	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	CD16-mediated activation of phosphatidylinositol-3_kinase -LRB- PI-3K -RRB- in human NK cells involves tyrosine phosphorylation of Cbl and its association with Grb2 , Shc , pp36 and p85 PI-3K subunit .
9880513	0	tyrosine	63,71	Cbl	118,121	tyrosine	Cbl	CHEBI:18186	867	Chemical	Gene	Syk|amod|START_ENTITY association|nmod|Syk substrates|nsubj|association substrates|dobj|END_ENTITY	Phosphorylation - and activation-independent association of the tyrosine kinase Syk and the tyrosine kinase substrates Cbl and Vav with tubulin in B-cells .
9890970	0	tyrosine	43,51	Cbl	20,23	tyrosine	Cbl	CHEBI:18186	500985(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|associates associates|nmod|END_ENTITY	Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl , a binding site for phosphatidylinositol 3-kinase .
22888118	0	tyrosine	72,80	Cbl-c	106,111	tyrosine	Cbl-c	CHEBI:18186	23624	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Structural flexibility regulates phosphopeptide-binding activity of the tyrosine kinase binding domain of Cbl-c .
17287826	0	tyrosine	82,90	Cdc25	68,73	tyrosine	Cdc25	CHEBI:18186	995	Chemical	Gene	phosphatases|compound|START_ENTITY phosphatases|amod|END_ENTITY	Inhibiting transient protein-protein interactions : lessons from the Cdc25 protein tyrosine phosphatases .
10490648	0	tyrosine	95,103	Cdc28	123,128	tyrosine	Cdc28	CHEBI:18186	852457(Tax:4932)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|kinase kinase|amod|END_ENTITY	Hsl7 localizes to a septin ring and serves as an adapter in a regulatory pathway that relieves tyrosine phosphorylation of Cdc28 protein kinase in Saccharomyces_cerevisiae .
8887667	0	tyrosine	91,99	Cdc28	114,119	tyrosine	Cdc28	CHEBI:18186	852457(Tax:4932)	Chemical	Gene	residue|amod|START_ENTITY residue|nmod|END_ENTITY	Spindle pole body separation in Saccharomyces_cerevisiae requires dephosphorylation of the tyrosine 19 residue of Cdc28 .
8930890	0	tyrosine	6,14	Cdc28	0,5	tyrosine	Cdc28	CHEBI:18186	852457(Tax:4932)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Cdc28 tyrosine phosphorylation and the morphogenesis checkpoint in budding yeast .
11087735	0	tyrosine	133,141	Cdc42Hs-associated_kinase-1	95,122	tyrosine	Cdc42Hs-associated kinase-1	CHEBI:18186	10188	Chemical	Gene	kinase|compound|START_ENTITY END_ENTITY|nmod|kinase	Stimulation of M3 muscarinic receptors induces phosphorylation of the Cdc42 effector activated Cdc42Hs-associated_kinase-1 via a Fyn tyrosine kinase signaling pathway .
9989807	0	tyrosine	79,87	Cdk2	109,113	tyrosine	Cdk2	CHEBI:18186	1017	Chemical	Gene	dephosphorylation|amod|START_ENTITY dephosphorylation|nmod|END_ENTITY	A rate limiting function of cdc25A for S phase entry inversely correlates with tyrosine dephosphorylation of Cdk2 .
7630405	0	tyrosine	16,24	Cdk4	44,48	tyrosine	Cdk4	CHEBI:18186	1019	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Requirement for tyrosine phosphorylation of Cdk4 in G1 arrest induced by ultraviolet irradiation .
9989806	0	tyrosine	47,55	Cdk4	75,79	tyrosine	Cdk4	CHEBI:18186	94201(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Cell cycle start from quiescence controlled by tyrosine phosphorylation of Cdk4 .
10896159	0	tyrosine	49,57	Cdk5	44,48	tyrosine	Cdk5	CHEBI:18186	1020	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation , kinase upregulation , and neurite outgrowth .
1403093	0	tyrosine	31,39	Cek5	0,4	tyrosine	Cek5	CHEBI:18186	396513(Tax:9031)	Chemical	Gene	kinase|compound|START_ENTITY END_ENTITY|appos|kinase	Cek5 , a membrane receptor-type tyrosine kinase , is in neurons of the embryonic and postnatal avian brain .
8808406	0	tyrosine	13,21	Cek8	30,34	tyrosine	Cek8	CHEBI:18186	395559(Tax:9031)	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	The receptor tyrosine kinase , Cek8 , is transiently expressed on subtypes of motoneurons in the spinal cord during development .
9543337	0	tyrosine	64,72	Cek8	81,85	tyrosine	Cek8	CHEBI:18186	395559(Tax:9031)	Chemical	Gene	START_ENTITY|dobj|kinase kinase|appos|END_ENTITY	Normal ontogenic observations on the expression of Eph receptor tyrosine kinase , Cek8 , in chick embryos .
11309195	0	tyrosine	49,57	Chk	45,48	tyrosine	Chk	CHEBI:18186	4145	Chemical	Gene	kinase|amod|START_ENTITY kinase|amod|END_ENTITY	Overexpression of the Csk_homologous_kinase -LRB- Chk tyrosine kinase -RRB- induces multinucleation : a possible role for chromosome-associated Chk in chromosome dynamics .
15748901	0	tyrosine	82,90	Chk	78,81	tyrosine	Chk	CHEBI:18186	4145	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Multi-lobulation of the nucleus in prolonged S phase by nuclear expression of Chk tyrosine kinase .
8995444	0	tyrosine	18,26	Chk	0,3	tyrosine	Chk	CHEBI:18186	4145	Chemical	Gene	kinase|compound|START_ENTITY END_ENTITY|appos|kinase	Chk , a Csk family tyrosine protein kinase , exhibits Csk-like activity in fibroblasts , but not in an antigen-specific T-cell line .
22372951	0	tyrosine	39,47	Ciliary_neurotrophic_factor	0,27	tyrosine	Ciliary neurotrophic factor	CHEBI:18186	1270	Chemical	Gene	START_ENTITY|nsubj|stimulates stimulates|compound|END_ENTITY	Ciliary_neurotrophic_factor stimulates tyrosine hydroxylase activity .
7512571	0	tyrosine	110,118	Ciliary_neurotrophic_factor	0,27	tyrosine	Ciliary neurotrophic factor	CHEBI:18186	1270	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation leukemia_inhibitory_factor|parataxis|induces leukemia_inhibitory_factor|amod|END_ENTITY	Ciliary_neurotrophic_factor / leukemia_inhibitory_factor / interleukin_6 / oncostatin_M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors .
12925758	0	tyrosine	10,18	Cortactin	0,9	tyrosine	Cortactin	CHEBI:18186	2017	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Cortactin tyrosine phosphorylation requires Rac1 activity and association with the cortical actin cytoskeleton .
22479425	0	tyrosine	10,18	Cortactin	0,9	tyrosine	Cortactin	CHEBI:18186	2017	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Cortactin tyrosine phosphorylation promotes its deacetylation and inhibits cell spreading .
9013573	0	tyrosine	20,28	Cripto	0,6	tyrosine	Cripto	CHEBI:18186	6997	Chemical	Gene	phosphorylation|amod|START_ENTITY enhances|dobj|phosphorylation enhances|nsubj|END_ENTITY	Cripto enhances the tyrosine phosphorylation of Shc and activates mitogen-activated protein kinase -LRB- MAPK -RRB- in mammary epithelial cells .
18835194	0	tyrosine	34,42	Crk	74,77	tyrosine	Crk	CHEBI:18186	1398	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Inhibitory receptor signaling via tyrosine phosphorylation of the adaptor Crk .
8524328	0	tyrosine	88,96	Crk	79,82	tyrosine	Crk	CHEBI:18186	1398	Chemical	Gene	manner|amod|START_ENTITY END_ENTITY|nmod|manner	The product of the cbl oncogene forms stable complexes in vivo with endogenous Crk in a tyrosine phosphorylation-dependent manner .
9195921	0	tyrosine	35,43	Crk	63,66	tyrosine	Crk	CHEBI:18186	1398	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Sphingosine_1-phosphate stimulates tyrosine phosphorylation of Crk .
12746446	0	tyrosine	23,31	Crk-associated_substrate	51,75	tyrosine	Crk-associated substrate	CHEBI:18186	25414(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Glucose stimulates the tyrosine phosphorylation of Crk-associated_substrate in pancreatic beta-cells .
15247284	0	tyrosine	21,29	Crk-associated_substrate	55,79	tyrosine	Crk-associated substrate	CHEBI:18186	12927(Tax:10090)	Chemical	Gene	sites|amod|START_ENTITY sites|nmod|END_ENTITY	Subsets of the major tyrosine phosphorylation sites in Crk-associated_substrate -LRB- CAS -RRB- are sufficient to promote cell migration .
7577968	0	tyrosine	104,112	Crk-associated_substrate	132,156	tyrosine	Crk-associated substrate	CHEBI:18186	12927(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Melanoma growth stimulatory activity signaling through the class II interleukin-8 receptor enhances the tyrosine phosphorylation of Crk-associated_substrate , p130 , and a 70-kilodalton protein .
8670206	0	tyrosine	56,64	Crk-associated_substrate_p130Cas	84,116	tyrosine	Crk-associated substrate p130Cas	CHEBI:18186	9564	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Src kinase plays an essential role in integrin-mediated tyrosine phosphorylation of Crk-associated_substrate_p130Cas .
9344843	0	tyrosine	31,39	CrkL	59,63	tyrosine	CrkL	CHEBI:18186	12929(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Erythropoietin and IL-3 induce tyrosine phosphorylation of CrkL and its association with Shc , SHP-2 , and Cbl in hematopoietic cells .
10329710	1	tyrosine	169,177	Csk	154,157	tyrosine	CHK	CHEBI:18186	29194(Tax:10116)	Chemical	Gene	family|compound|START_ENTITY family|compound|END_ENTITY	Csk_homologous_kinase -LRB- CHK -RRB- , a member of the Csk regulatory tyrosine kinase family , is expressed primarily in brain and hematopoietic cells .
11158295	0	tyrosine	54,62	Csk	70,73	tyrosine	Csk	CHEBI:18186	1445	Chemical	Gene	interaction|nmod|START_ENTITY kinase|nsubj|interaction kinase|dobj|END_ENTITY	SH2 domain-mediated interaction of inhibitory protein tyrosine kinase Csk with protein tyrosine phosphatase-HSCF .
15683240	0	tyrosine	84,92	Csk	101,104	tyrosine	Csk	CHEBI:18186	1445	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	Probing the communication between the regulatory and catalytic domains of a protein tyrosine kinase , Csk .
16439366	0	tyrosine	73,81	Csk	113,116	tyrosine	Csk	CHEBI:18186	1445	Chemical	Gene	START_ENTITY|dobj|kinase kinase|appos|END_ENTITY	Docking-based substrate recognition by the catalytic domain of a protein tyrosine kinase , C-terminal_Src_kinase -LRB- Csk -RRB- .
16501257	0	tyrosine	8,16	Csk	24,27	tyrosine	Csk	CHEBI:18186	12988(Tax:10090)	Chemical	Gene	Role|nmod|START_ENTITY kinase|nsubj|Role kinase|dobj|END_ENTITY	Role of tyrosine kinase Csk in G protein-coupled receptor - and receptor tyrosine kinase-induced fibroblast cell migration .
17936985	0	tyrosine	53,61	Csk	42,45	tyrosine	Csk	CHEBI:18186	1445	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	-LSB- Obtaining a full-length encoding cDNA of Csk family tyrosine kinase from human lymphocytes -RSB- .
7529872	0	tyrosine	18,26	Csk	14,17	tyrosine	Csk	CHEBI:18186	1445	Chemical	Gene	kinase|amod|START_ENTITY END_ENTITY|amod|kinase	Overexpressed Csk tyrosine kinase is localized in focal adhesions , causes reorganization of alpha v beta 5 integrin , and interferes with HeLa cell spreading .
8995444	0	tyrosine	18,26	Csk	7,10	tyrosine	Csk	CHEBI:18186	1445	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Chk , a Csk family tyrosine protein kinase , exhibits Csk-like activity in fibroblasts , but not in an antigen-specific T-cell line .
12218089	0	tyrosine	35,43	Csk-binding_protein	63,82	tyrosine	Csk-binding protein	CHEBI:18186	94212(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Cutting edge : Fyn is essential for tyrosine phosphorylation of Csk-binding_protein / phosphoprotein associated with glycolipid-enriched microdomains in lipid rafts in resting T cells .
16524250	0	tyrosine	57,65	Cyclic_nucleotide_phosphodiesterase	0,35	tyrosine	Cyclic nucleotide phosphodiesterase	CHEBI:18186	5140	Chemical	Gene	START_ENTITY|nsubj|increases increases|amod|END_ENTITY	Cyclic_nucleotide_phosphodiesterase inhibition increases tyrosine phosphorylation and hyper motility in normal and pathological human spermatozoa .
1850698	0	tyrosine	20,28	Cyclin	0,6	tyrosine	Cyclin	CHEBI:18186	5111	Chemical	Gene	phosphorylation|amod|START_ENTITY promotes|dobj|phosphorylation promotes|nsubj|END_ENTITY	Cyclin promotes the tyrosine phosphorylation of p34cdc2 in a wee1 + dependent manner .
9121472	6	tyrosine	1161,1169	D-Cbl	1189,1194	tyrosine	c-Cbl	CHEBI:18186	867	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	A point mutation in D-Cbl -LRB- G305E -RRB- that suppresses the negative regulation of LET-23 by the Cbl homolog Sli-1 in C. _ elegans prevented tyrosine phosphorylation of D-Cbl as well as binding to the liganded EGF receptor in COS-1 cells .
15136580	0	tyrosine	48,56	DDR1	43,47	tyrosine	DDR1	CHEBI:18186	780	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Exploring the collagen-binding site of the DDR1 tyrosine kinase receptor .
20380825	0	tyrosine	18,26	DDR1	63,67	tyrosine	DDR1	CHEBI:18186	780	Chemical	Gene	Expression|nmod|START_ENTITY kinase|nsubj|Expression kinase|dobj|END_ENTITY	Expression of the tyrosine kinase discoidin domain receptor 1 -LRB- DDR1 -RRB- in human central nervous system myelin .
21398698	0	tyrosine	14,22	DDR1	0,4	tyrosine	DDR1	CHEBI:18186	780	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	DDR1 receptor tyrosine kinase promotes prosurvival pathway through Notch1 activation .
23899692	0	tyrosine	50,58	DDR1	36,40	tyrosine	DDR1	CHEBI:18186	780	Chemical	Gene	START_ENTITY|nsubj|Discovery Discovery|nmod|receptor receptor|compound|END_ENTITY	Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor .
12765478	0	tyrosine	23,31	DDR2	39,43	tyrosine	DDR2	CHEBI:18186	4921	Chemical	Gene	expression|nmod|START_ENTITY kinase|nsubj|expression kinase|dobj|END_ENTITY	Elevated expression of tyrosine kinase DDR2 in primary_biliary_cirrhosis .
23131558	0	tyrosine	101,109	DDR2	0,4	tyrosine	DDR2	CHEBI:18186	4921	Chemical	Gene	kinase|amod|START_ENTITY DDR2|amod|kinase plays|dobj|DDR2 plays|nsubj|END_ENTITY	DDR2 plays a role in fibroblast migration independent of adhesion ligand and collagen activated DDR2 tyrosine kinase .
23131558	0	tyrosine	101,109	DDR2	96,100	tyrosine	DDR2	CHEBI:18186	4921	Chemical	Gene	kinase|amod|START_ENTITY END_ENTITY|amod|kinase	DDR2 plays a role in fibroblast migration independent of adhesion ligand and collagen activated DDR2 tyrosine kinase .
16682945	0	tyrosine	14,22	DEP-1	0,5	tyrosine	DEP-1	CHEBI:18186	5795	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|compound|END_ENTITY	DEP-1 protein tyrosine phosphatase inhibits proliferation and migration of colon_carcinoma cells and is upregulated by protective nutrients .
12370829	0	tyrosine	35,43	DEP1	56,60	tyrosine	DEP1	CHEBI:18186	5795	Chemical	Gene	START_ENTITY|dobj|interacts interacts|compound|END_ENTITY	The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120 -LRB- ctn -RRB- .
1281555	0	tyrosine	42,50	DNA_binding_protein	78,97	tyrosine	DNA binding protein	CHEBI:18186	284390	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Activation of transcription by IFN-gamma : tyrosine phosphorylation of a 91-kD DNA_binding_protein .
8226938	0	tyrosine	32,40	DPTP4E	59,65	tyrosine	DPTP4E	CHEBI:18186	31425(Tax:7227)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Alternative splicing in a novel tyrosine phosphatase gene -LRB- DPTP4E -RRB- of Drosophila_melanogaster generates two large receptor-like proteins which differ in their carboxyl termini .
16699184	0	tyrosine	67,75	DSP18	19,24	tyrosine	DSP18	CHEBI:18186	150290	Chemical	Gene	START_ENTITY|nsubj|Structure Structure|nmod|END_ENTITY	Structure of human DSP18 , a member of the dual-specificity protein tyrosine phosphatase family .
7857657	0	tyrosine	24,32	DTK	41,44	tyrosine	DTK	CHEBI:18186	22174(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	Isolation of a receptor tyrosine kinase -LRB- DTK -RRB- from embryonic stem cells : structure , genetic mapping and analysis of expression .
16046028	0	tyrosine	106,114	Dab1	101,105	tyrosine	Dab1	CHEBI:18186	1600	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Both the phosphoinositide and receptor binding activities of Dab1 are required for Reelin-stimulated Dab1 tyrosine phosphorylation .
16600913	6	tyrosine	744,752	Dab1	739,743	tyrosine	Hsf2	CHEBI:18186	15500(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	The levels of Reelin and Dab1 tyrosine phosphorylation were reduced , suggesting that the Reelin cascade is affected in Hsf2 - / - cortices .
17394141	0	tyrosine	104,112	Dab1	99,103	tyrosine	Dab1	CHEBI:18186	13131(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Migration of sympathetic preganglionic neurons in the spinal cord is regulated by Reelin-dependent Dab1 tyrosine phosphorylation and CrkL .
10652228	0	tyrosine	82,90	Dbl	53,56	tyrosine	Dbl	CHEBI:18186	4168	Chemical	Gene	START_ENTITY|nsubj|Activation Activation|nmod|END_ENTITY	Activation of the guanine_nucleotide exchange factor Dbl following ACK1-dependent tyrosine phosphorylation .
19671659	0	tyrosine	64,72	Ddr2	95,99	tyrosine	Ddr2	CHEBI:18186	18214(Tax:10090)	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Transcriptome analysis reveals an unexpected role of a collagen tyrosine kinase receptor gene , Ddr2 , as a regulator of ovarian function .
12670700	0	tyrosine	56,64	Disabled-1	84,94	tyrosine	Disabled-1	CHEBI:18186	13131(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Binding of purified Reelin to ApoER2 and VLDLR mediates tyrosine phosphorylation of Disabled-1 .
22394407	0	tyrosine	106,114	Disabled-1	95,105	tyrosine	Disabled-1	CHEBI:18186	1600	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Reelin regulates differentiation of neural stem cells by activation of notch signaling through Disabled-1 tyrosine phosphorylation .
16912190	0	tyrosine	37,45	Discoidin_domain_receptor_1	0,27	tyrosine	Discoidin domain receptor 1	CHEBI:18186	780	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Discoidin_domain_receptor_1 receptor tyrosine kinase induces cyclooxygenase-2 and promotes chemoresistance through nuclear_factor-kappaB pathway activation .
12754255	0	tyrosine	13,21	Dlxin-1	104,111	tyrosine	Dlxin-1	CHEBI:18186	9500	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|nmod|END_ENTITY	The receptor tyrosine kinase Ror2 associates with the melanoma-associated_antigen -LRB- MAGE -RRB- family protein Dlxin-1 and regulates its intracellular distribution .
14647425	0	tyrosine	87,95	Dok-1	50,55	tyrosine	Dok-1	CHEBI:18186	1796	Chemical	Gene	proteins|nmod|START_ENTITY proteins|amod|END_ENTITY	Functional interaction of RasGAP-binding proteins Dok-1 and Dok-2 with the Tec protein tyrosine kinase .
21536658	0	tyrosine	10,18	Dok-1	34,39	tyrosine	Dok-1	CHEBI:18186	1796	Chemical	Gene	kinases|nsubj|START_ENTITY kinases|dobj|END_ENTITY	Oncogenic tyrosine kinases target Dok-1 for ubiquitin-mediated proteasomal degradation to promote cell transformation .
8641360	0	tyrosine	17,25	Dtk	4,7	tyrosine	Dtk	CHEBI:18186	7301	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The Dtk receptor tyrosine kinase , which binds protein S , is expressed during hematopoiesis .
23948904	0	tyrosine	17,25	Dyrk1A	63,69	tyrosine	Dyrk1A	CHEBI:18186	1859	Chemical	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	Dual-specificity tyrosine phosphorylation-regulated kinase 1A -LRB- Dyrk1A -RRB- enhances tau expression .
10742310	0	tyrosine	79,87	E-cadherin	107,117	tyrosine	E-cadherin	CHEBI:18186	83502(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Platelet-activating factor increases mucosal permeability in rat intestine via tyrosine phosphorylation of E-cadherin .
9811344	0	tyrosine	100,108	E-cadherin	128,138	tyrosine	E-cadherin	CHEBI:18186	999	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Cytoplasmic redistribution of E-cadherin-catenin adhesion complex is associated with down-regulated tyrosine phosphorylation of E-cadherin in human bronchopulmonary_carcinomas .
11078389	8	tyrosine	1205,1213	EGF	1184,1187	tyrosine	HGF	CHEBI:18186	100316908(Tax:9986)	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	The inhibition of EGF and HGF receptor tyrosine kinase activity by lavendustin_A was confirmed by Western blotting .
17913856	0	tyrosine	146,154	EGF	133,136	tyrosine	EGF	CHEBI:18186	1950	Chemical	Gene	inhibition|compound|START_ENTITY END_ENTITY|dobj|inhibition	Expression of epidermal_growth_factor -LRB- EGF -RRB- / transforming_growth_factor-alpha by human lung_cancer cells determines their response to EGF receptor tyrosine kinase inhibition in the lungs of mice .
1801683	0	tyrosine	23,31	EGF	0,3	tyrosine	EGF	CHEBI:18186	1950	Chemical	Gene	phosphorylation|amod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	EGF rapidly stimulates tyrosine phosphorylation in cultured endometrial cells .
6316166	0	tyrosine	20,28	EGF	52,55	tyrosine	EGF	CHEBI:18186	1950	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|receptor receptor|compound|END_ENTITY	Diminished in vitro tyrosine kinase activity of the EGF receptor of senescent human fibroblasts .
8125255	0	tyrosine	78,86	EGF	65,68	tyrosine	EGF	CHEBI:18186	13645(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase .
8378774	0	tyrosine	41,49	EGF	13,16	tyrosine	EGF	CHEBI:18186	13645(Tax:10090)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction by EGF and interferon-gamma of tyrosine phosphorylated DNA binding proteins in mouse liver nuclei .
8548502	0	tyrosine	37,45	EGF	56,59	tyrosine	EGF	CHEBI:18186	25313(Tax:10116)	Chemical	Gene	activation|nmod|START_ENTITY kinase|nsubj|activation kinase|nmod|END_ENTITY	Increased activation of EGF-receptor tyrosine kinase by EGF and TGF-alpha in the colonic_mucosa of aged rats .
8711138	0	tyrosine	103,111	EGF	90,93	tyrosine	EGF	CHEBI:18186	1950	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|compound|END_ENTITY	Genistein suppresses EGF-induced prostaglandin biosynthesis by a mechanism independent of EGF receptor tyrosine kinase inhibition .
9759855	0	tyrosine	162,170	EGF	149,152	tyrosine	EGF	CHEBI:18186	1950	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Epidermal_growth_factor -LRB- EGF -RRB- modulates fetal thymocyte growth and differentiation : partial reversal by insulin , mimicking by specific inhibitors of EGF receptor tyrosine kinase activity , and differential expression of CD45 phosphatase isotypes .
10463775	0	tyrosine	247,255	EGF-R	241,246	tyrosine	EGF-R	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The anti-proliferative effects of tyrosine kinase inhibitors towards tamoxifen-sensitive and tamoxifen-resistant human breast_cancer cell lines in relation to the expression of epidermal_growth_factor_receptors -LRB- EGF-R -RRB- and the inhibition of EGF-R tyrosine kinase .
9164515	0	tyrosine	58,66	EGF-R	51,56	tyrosine	EGF-R	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|activation activation|appos|END_ENTITY	Differential activation of total and EGF_receptor -LRB- EGF-R -RRB- tyrosine kinase -LRB- tyr-k -RRB- in the rectal mucosa in patients with adenomatous_polyps , ulcerative_colitis and colon_cancer .
9185705	0	tyrosine	20,28	EGF-R	4,9	tyrosine	EGF-R	CHEBI:18186	1956	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	New EGF-R selective tyrosine kinase inhibitor reveals variable growth responses in prostate_carcinoma cell lines PC-3 and DU-145 .
9193132	7	tyrosine	1365,1373	EGF-R	1359,1364	tyrosine	c-SRC	CHEBI:18186	6714	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	In vitro , the most active compounds -LRB- CGP_59 326 , CGP 60 261 , CGP_62 706 -RRB- inhibited the EGF-R tyrosine kinase with IC50 value between 6-30 nM .
9374534	0	tyrosine	26,34	EGF-R	43,48	tyrosine	EGF-R	CHEBI:18186	1956	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|amod|END_ENTITY	Interaction of a receptor tyrosine kinase , EGF-R , with caveolins .
10090785	0	tyrosine	52,60	EGFR	47,51	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|amod|END_ENTITY	Use of a pharmacophore model for the design of EGFR tyrosine kinase inhibitors : isoflavones and 3-phenyl-4 -LRB- 1H -RRB- - quinolones .
11156248	0	tyrosine	142,150	EGFR	137,141	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 -LRB- Iressa -RRB- , an inhibitor of EGFR tyrosine kinase .
11585755	0	tyrosine	49,57	EGFR	43,47	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	The characterization of novel , dual ErbB-2 / EGFR , tyrosine kinase inhibitors : potential therapy for cancer .
12497200	0	tyrosine	77,85	EGFR	72,76	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	properties|amod|START_ENTITY properties|amod|END_ENTITY	The combi-targeting concept : a novel 3,3-disubstituted _ nitrosourea with EGFR tyrosine kinase inhibitory properties .
12502359	1	tyrosine	166,174	EGFR	232,236	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|epidermal_growth_factor_receptor epidermal_growth_factor_receptor|appos|END_ENTITY	The design of an orally active , irreversible inhibitor of the tyrosine kinase activity of the epidermal_growth_factor_receptor -LRB- EGFR -RRB- and the human epidermal_growth_factor_receptor-2 -LRB- HER-2 -RRB- .
12639547	0	tyrosine	63,71	EGFR	58,62	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Discovery and biological evaluation of potent dual ErbB-2 / EGFR tyrosine kinase inhibitors : 6-thiazolylquinazolines .
12743604	0	tyrosine	103,111	EGFR	98,102	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|amod|END_ENTITY	Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors .
12792773	0	tyrosine	93,101	EGFR	88,92	tyrosine	EGFR	CHEBI:18186	13649(Tax:10090)	Chemical	Gene	ZD1839|amod|START_ENTITY ZD1839|compound|END_ENTITY	Gene-expression profiles of human tumor xenografts in nude_mice treated orally with the EGFR tyrosine kinase inhibitor ZD1839 .
12867061	0	tyrosine	38,46	EGFR	33,37	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|studies studies|nmod|END_ENTITY	Clinical studies with non-iressa EGFR tyrosine kinase inhibitors .
14666659	0	tyrosine	73,81	EGFR	29,33	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|Distribution Distribution|nmod|END_ENTITY	Distribution and function of EGFR in human tissue and the effect of EGFR tyrosine kinase inhibition .
15081028	0	tyrosine	135,143	EGFR	130,134	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Synthesis and biological evaluation of benzamides and benzamidines : structural requirement of a pyrimidine ring for inhibition of EGFR tyrosine kinase .
15185372	0	tyrosine	124,132	EGFR	107,111	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Design , synthesis , and biological evaluation of aminoboronic_acids as growth-factor receptor inhibitors of EGFR and VEGFR-1 tyrosine kinases .
15382076	1	tyrosine	283,291	EGFR	278,282	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	The mechanism of action of ZR2002 , a chimeric amino_quinazoline designed to possess mixed EGFR tyrosine kinase -LRB- TK -RRB- inhibitory and DNA targeting properties , was compared to those of ZR01 , a reversible inhibitor of the same class and PD168393 , a known irreversible inhibitor of EGFR .
15928657	0	tyrosine	44,52	EGFR	39,43	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	ZD6474 -- a novel inhibitor of VEGFR and EGFR tyrosine kinase activity .
15976335	0	tyrosine	142,150	EGFR	137,141	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|amod|END_ENTITY	Metaplastic breast_carcinomas are negative for Her-2 but frequently express EGFR -LRB- Her-1 -RRB- : potential relevance to adjuvant treatment with EGFR tyrosine kinase inhibitors ?
16011858	0	tyrosine	17,25	EGFR	47,51	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|gene gene|amod|END_ENTITY	Mutations in the tyrosine kinase domain of the EGFR gene associated with gefitinib response in non-small-cell_lung_cancer .
16111887	0	tyrosine	45,53	EGFR	23,27	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	New dual inhibitors of EGFR and HER2 protein tyrosine kinases .
16161043	0	tyrosine	19,27	EGFR	14,18	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Her-2 / neu and EGFR tyrosine kinase activation predict the efficacy of trastuzumab-based therapy in patients with metastatic breast_cancer .
16211656	0	tyrosine	111,119	EGFR	106,110	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|amod|END_ENTITY	Synthesis and biological evaluation of bis -LRB- methoxy_methyl -RRB- -7,8 - dihydro - -LSB- 1,4 -RSB- dioxino -LSB- 2,3-g -RSB- quinazolines as EGFR tyrosine kinase inhibitors .
16330885	0	tyrosine	5,13	EGFR	0,4	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	EGFR tyrosine kinase inhibitors in non-small_cell_lung_cancer : report of a 3-year_compassionate use experience with gefitinib in stage IIIB/IV outpatients .
16336751	7	tyrosine	1257,1265	EGFR	1252,1256	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|amod|END_ENTITY	The differences between NSCLC and CRC with respect to EGFR expression and mutation status do not completely explain this dichotomy , and further investigation into the pharmacogenomics of EGFR tyrosine kinase inhibition in CRC is under way .
16495036	6	tyrosine	1117,1125	EGFR	1112,1116	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	This EGFR-supported transactivation is strongly dependent on EGFR tyrosine kinase , c-Src , and the c-Src-specific EGFR tyrosine residue 845 and represents a novel paradigm of EGFR transactivation .
16514409	0	tyrosine	17,25	EGFR	47,51	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|gene gene|amod|END_ENTITY	Mutations in the tyrosine kinase domain of the EGFR gene are rare in synovial_sarcoma .
16516204	0	tyrosine	112,120	EGFR	95,99	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	phosphatases|compound|START_ENTITY phosphatases|compound|END_ENTITY	Activation of ErbB2 by 2-methyl-1 ,4 - naphthoquinone -LRB- menadione -RRB- in human keratinocytes : role of EGFR and protein tyrosine phosphatases .
16552419	0	tyrosine	21,29	EGFR	47,51	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|gene gene|amod|END_ENTITY	Mutations within the tyrosine kinase domain of EGFR gene specifically occur in lung_adenocarcinoma patients with a low exposure of tobacco smoking .
16843263	0	tyrosine	123,131	EGFR	118,122	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|amod|END_ENTITY	HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors .
16885373	0	tyrosine	172,180	EGFR	167,171	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	gefitinib|amod|START_ENTITY gefitinib|compound|END_ENTITY	Responses of human colorectal_tumor cells to treatment with the anti-epidermal_growth_factor_receptor monoclonal antibody ICR62 used alone and in combination with the EGFR tyrosine kinase inhibitor gefitinib .
16891020	0	tyrosine	34,42	EGFR	29,33	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|amod|END_ENTITY	Antiproliferative effects of EGFR tyrosine kinase inhibition and radiation-induced genotoxic_injury are attenuated by adhesion to fibronectin .
17059835	0	tyrosine	67,75	EGFR	62,66	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|amod|END_ENTITY	Compensatory increases in Her-2 / neu activation in response to EGFR tyrosine kinase inhibition in colon_cancer cell lines .
17250463	0	tyrosine	45,53	EGFR	31,35	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Lapatinib : a dual inhibitor of EGFR and HER2 tyrosine kinase activity .
17270437	0	tyrosine	77,85	EGFR	55,59	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	New C-5 substituted pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases .
17368025	0	tyrosine	79,87	EGFR	57,61	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Novel C-5 aminomethyl_pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases .
17431338	0	tyrosine	37,45	EGFR	89,93	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Prediction of effectiveness of EGFR tyrosine kinase inhibitors for the patients with by EGFR mutations -RSB- .
17606372	0	tyrosine	90,98	EGFR	68,72	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	5 - -LRB- -LRB- 4-Aminopiperidin-1-yl -RRB- methyl -RRB- pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases .
17631646	0	tyrosine	172,180	EGFR	167,171	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Induction of cell cycle arrest and apoptosis in human nasopharyngeal_carcinoma cells by ZD6474 , an inhibitor of VEGFR tyrosine kinase with additional activity against EGFR tyrosine kinase .
17699871	7	tyrosine	1036,1044	EGFR	1031,1035	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Phosphorylation of HER2 in HR cells was inhibited by the EGFR tyrosine kinase inhibitors erlotinib and gefitinib .
17869510	0	tyrosine	122,130	EGFR	117,121	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Synthesis and inhibitory activity of 4-alkynyl and 4-alkenylquinazolines : identification of new scaffolds for potent EGFR tyrosine kinase inhibitors .
18058367	0	tyrosine	35,43	EGFR	30,34	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Pharmacological inhibition of EGFR tyrosine kinase affects ILK-mediated cellular radiosensitization in vitro .
18182285	0	tyrosine	72,80	EGFR	48,52	tyrosine	EGFR	CHEBI:18186	24329(Tax:10116)	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Novel 3-alkoxy-1H-pyrazolo -LSB- 3,4-d -RSB- pyrimidines as EGFR and erbB2 receptor tyrosine kinase inhibitors .
18222149	0	tyrosine	24,32	EGFR	0,4	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|mutations mutations|amod|END_ENTITY	EGFR mutations and EGFR tyrosine kinase inhibition in non-small_cell_lung_cancer .
18465761	0	tyrosine	144,152	EGFR	139,143	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Allene as an alternative functional group for drug design : effect of C -- C multiple bonds conjugated with quinazolines on the inhibition of EGFR tyrosine kinase .
18493719	0	tyrosine	35,43	EGFR	30,34	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|activity activity|nmod|END_ENTITY	Antitumor activity of a novel EGFR tyrosine kinase inhibitor against human lung_carcinoma in vitro and in vivo .
18546267	0	tyrosine	106,114	EGFR	101,105	tyrosine	EGFR	CHEBI:18186	13649(Tax:10090)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Synergistic inhibition of head_and_neck_tumor growth by green tea -LRB- - -RRB- - epigallocatechin-3-gallate and EGFR tyrosine kinase inhibitor .
18568074	0	tyrosine	28,36	EGFR	23,27	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins .
18678492	0	tyrosine	120,128	EGFR	115,119	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Design , synthesis and in vitro antitumor activity of 4-aminoquinoline and 4-aminoquinazoline derivatives targeting EGFR tyrosine kinase .
18682844	0	tyrosine	37,45	EGFR	32,36	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	HER2 oncogenic function escapes EGFR tyrosine kinase inhibitors via activation of alternative HER receptors in breast_cancer cells .
19299077	0	tyrosine	36,44	EGFR	31,35	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|activity activity|nmod|END_ENTITY	Anti-tumor activity of a novel EGFR tyrosine kinase inhibitor against human NSCLC in vitro and in vivo .
19562712	0	tyrosine	16,24	EGFR	11,15	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of EGFR tyrosine kinase inhibitor erlotinib in prostate_cancer cells in vitro .
19680293	0	tyrosine	109,117	EGFR	104,108	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|amod|END_ENTITY	Activating and resistance mutations of EGFR in non-small-cell_lung_cancer : role in clinical response to EGFR tyrosine kinase inhibitors .
19696185	0	tyrosine	5,13	EGFR	0,4	tyrosine	EGFR	CHEBI:18186	13649(Tax:10090)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	EGFR tyrosine kinase inhibitor -LRB- PD153035 -RRB- improves glucose tolerance and insulin action in high-fat diet-fed mice .
20139705	0	tyrosine	15,23	EGFR	44,48	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|nmod|END_ENTITY	ZD6474 , a dual tyrosine kinase inhibitor of EGFR and VEGFR-2 , inhibits MAPK/ERK and AKT/PI3-K and induces apoptosis in breast_cancer cells .
20160029	0	tyrosine	76,84	EGFR	71,75	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	HER kinase axis receptor dimer partner switching occurs in response to EGFR tyrosine kinase inhibition despite failure to block cellular proliferation .
20583855	0	tyrosine	152,160	EGFR	146,150	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	Synthesis and antiproliferative activities against Hep-G2 of salicylanide derivatives : potent inhibitors of the epidermal_growth_factor_receptor -LRB- EGFR -RRB- tyrosine kinase .
20705357	0	tyrosine	105,113	EGFR	100,104	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	First-line therapy and methylation status of CHFR in serum influence outcome to chemotherapy versus EGFR tyrosine kinase inhibitors as second-line therapy in stage IV non-small-cell_lung_cancer patients .
21067705	0	tyrosine	93,101	EGFR	88,92	tyrosine	EGFR	CHEBI:18186	13649(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Mechanisms of myogenic tone of coronary arteriole : Role of down stream signaling of the EGFR tyrosine kinase .
21093094	0	tyrosine	89,97	EGFR	84,88	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	therapy|amod|START_ENTITY therapy|compound|END_ENTITY	New CT response criteria in non-small_cell_lung_cancer : proposal and application in EGFR tyrosine kinase inhibitor therapy .
21135146	0	tyrosine	28,36	EGFR	23,27	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Acquired resistance to EGFR tyrosine kinase inhibitors in EGFR-mutant lung_cancer : distinct natural history of patients with tumors harboring the T790M mutation .
21152424	0	tyrosine	36,44	EGFR	31,35	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Rapidly acquired resistance to EGFR tyrosine kinase inhibitors in NSCLC cell lines through de-repression of FGFR2 and FGFR3 expression .
21177105	0	tyrosine	86,94	EGFR	64,68	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Novel pyrrolo -LSB- 2,1-f -RSB- -LSB- 1,2,4 -RSB- triazin-4-amines : Dual inhibitors of EGFR and HER2 protein tyrosine kinases .
21196266	0	tyrosine	5,13	EGFR	0,4	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	EGFR tyrosine kinase inhibitors and multidrug resistance : perspectives .
21196276	0	tyrosine	5,13	EGFR	0,4	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	kinases|compound|START_ENTITY kinases|amod|END_ENTITY	EGFR tyrosine kinases inhibitors in cancer treatment : in vitro and in vivo evidence .
21254978	0	tyrosine	47,55	EGFR	42,46	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Novel substituted quinazolines for potent EGFR tyrosine kinase inhibitors .
21325444	0	tyrosine	91,99	EGFR	86,90	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Outcome of advanced NSCLC patients harboring sensitizing EGFR mutations randomized to EGFR tyrosine kinase inhibitors or chemotherapy as first-line treatment : a meta-analysis .
21409490	0	tyrosine	78,86	EGFR	73,77	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	therapy|amod|START_ENTITY therapy|compound|END_ENTITY	EGFR and p53 status of pulmonary pleomorphic_carcinoma : implications for EGFR tyrosine kinase inhibitors therapy of an aggressive lung_malignancy .
21471286	0	tyrosine	83,91	EGFR	78,82	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	gefitinib|amod|START_ENTITY gefitinib|compound|END_ENTITY	Pathway analysis of glioblastoma tissue after preoperative treatment with the EGFR tyrosine kinase inhibitor gefitinib -- a phase II trial .
21558399	0	tyrosine	190,198	EGFR	221,225	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|gene gene|amod|END_ENTITY	Molecular characteristics predict clinical outcomes : prospective trial correlating response to the EGFR tyrosine kinase inhibitor gefitinib with the presence of sensitizing mutations in the tyrosine binding domain of the EGFR gene .
21626329	0	tyrosine	112,120	EGFR	107,111	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	treatment|amod|START_ENTITY treatment|compound|END_ENTITY	The influence of intracellular epidermal_growth_factor_receptor -LRB- EGFR -RRB- signal activation on the outcome of EGFR tyrosine kinase inhibitor treatment for pulmonary_adenocarcinoma .
21655094	0	tyrosine	5,13	EGFR	0,4	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	EGFR tyrosine kinase inhibitors activate autophagy as a cytoprotective response in human lung_cancer cells .
21831955	0	tyrosine	31,39	EGFR	26,30	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|sensitivity sensitivity|nmod|END_ENTITY	Maintained sensitivity to EGFR tyrosine kinase inhibitors in EGFR-mutant lung_cancer recurring after adjuvant erlotinib or gefitinib .
21994417	0	tyrosine	83,91	EGFR	78,82	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	EGFR protein expression in non-small_cell_lung_cancer predicts response to an EGFR tyrosine kinase inhibitor -- a novel antibody for immunohistochemistry or AQUA technology .
22056888	0	tyrosine	17,25	EGFR	12,16	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Efficacy of EGFR tyrosine kinase inhibitors in patients with EGFR-mutated non-small-cell_lung_cancer : a meta-analysis of 13 randomized trials .
22061963	0	tyrosine	67,75	EGFR	62,66	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Human_ether - - go-go gene potassium channels are regulated by EGFR tyrosine kinase .
22101132	0	tyrosine	109,117	EGFR	94,98	tyrosine	EGFR	CHEBI:18186	13649(Tax:10090)	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Discovery of novel 5-alkynyl-4-anilinopyrimidines as potent , orally active dual inhibitors of EGFR and Her-2 tyrosine kinases .
22173702	1	tyrosine	210,218	EGFR	205,209	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	INTRODUCTION : EGFR-mutant lung_cancers are sensitive to EGFR tyrosine kinase inhibitors -LRB- TKIs -RRB- .
22198508	0	tyrosine	72,80	EGFR	67,71	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	kinase|amod|START_ENTITY kinase|amod|END_ENTITY	Modulation of human cardiac transient outward potassium current by EGFR tyrosine kinase and Src-family kinases .
22514494	0	tyrosine	50,58	EGFR	45,49	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	A personalized approach to treatment : use of EGFR tyrosine kinase inhibitors for the treatment of non-small-cell_lung_cancer in Canada .
22564276	0	tyrosine	50,58	EGFR	45,49	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Novel benzimidazole analogs as inhibitors of EGFR tyrosine kinase .
22622260	0	tyrosine	30,38	EGFR	76,80	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nmod|mutation mutation|compound|END_ENTITY	Differential sensitivities to tyrosine kinase inhibitors in NSCLC harboring EGFR mutation and ALK translocation .
22664249	0	tyrosine	17,25	EGFR	12,16	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	The role of EGFR tyrosine kinase inhibitors in the first-line treatment of advanced non_small_cell_lung_cancer patients harboring EGFR mutation .
22664249	0	tyrosine	17,25	EGFR	130,134	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|advcl|harboring harboring|dobj|mutation mutation|amod|END_ENTITY	The role of EGFR tyrosine kinase inhibitors in the first-line treatment of advanced non_small_cell_lung_cancer patients harboring EGFR mutation .
22673630	0	tyrosine	59,67	EGFR	54,58	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|heterogeneity heterogeneity|nmod|END_ENTITY	EGFR mutation heterogeneity and the mixed response to EGFR tyrosine kinase inhibitors of lung_adenocarcinomas .
22760226	0	tyrosine	17,25	EGFR	12,16	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|Efficacy Efficacy|nmod|END_ENTITY	Efficacy of EGFR tyrosine kinase inhibitors for non-adenocarcinoma NSCLC patients with EGFR mutation .
22760226	0	tyrosine	17,25	EGFR	87,91	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nmod|mutation mutation|amod|END_ENTITY	Efficacy of EGFR tyrosine kinase inhibitors for non-adenocarcinoma NSCLC patients with EGFR mutation .
22815900	0	tyrosine	79,87	EGFR	74,78	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Loss of activating EGFR mutant gene contributes to acquired resistance to EGFR tyrosine kinase inhibitors in lung_cancer cells .
22818848	0	tyrosine	83,91	EGFR	62,66	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Novel oxazolo -LSB- 4,5-g -RSB- quinazolin-2 -LRB- 1H -RRB- - ones : dual inhibitors of EGFR and Src protein tyrosine kinases .
22833077	0	tyrosine	118,126	EGFR	113,117	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Analysis of bypass signaling in EGFR pathway and profiling of bypass genes for predicting response to anticancer EGFR tyrosine kinase inhibitors .
22954701	0	tyrosine	5,13	EGFR	0,4	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|amod|END_ENTITY	EGFR tyrosine kinase inhibition induces autophagy in cancer cells .
23242437	0	tyrosine	45,53	EGFR	9,13	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|mutations mutations|compound|END_ENTITY	Compound EGFR mutations and response to EGFR tyrosine kinase inhibitors .
23266614	0	tyrosine	111,119	EGFR	106,110	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Effect of siRNAs targeting the EGFR T790M mutation in a non-small cell lung_cancer cell line resistant to EGFR tyrosine kinase inhibitors and combination with various agents .
23383079	0	tyrosine	45,53	EGFR	40,44	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Skin_rash could predict the response to EGFR tyrosine kinase inhibitor and the prognosis for patients with non-small_cell_lung_cancer : a systematic review and meta-analysis .
23395887	0	tyrosine	120,128	EGFR	106,110	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Downregulation of HER3 by a novel antisense oligonucleotide , EZN-3920 , improves the antitumor activity of EGFR and HER2 tyrosine kinase inhibitors in animal models .
23407558	0	tyrosine	177,185	EGFR	172,176	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|amod|END_ENTITY	Local therapy with continued EGFR tyrosine kinase inhibitor therapy as a treatment strategy in EGFR-mutant advanced lung_cancers that have developed acquired resistance to EGFR tyrosine kinase inhibitors .
23485129	0	tyrosine	111,119	EGFR	106,110	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Uncommon epidermal_growth_factor_receptor mutations in non-small_cell_lung_cancer and their mechanisms of EGFR tyrosine kinase inhibitors sensitivity and resistance .
23496660	0	tyrosine	5,13	EGFR	0,4	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	EGFR tyrosine kinase regulates human small-conductance Ca2 + - activated K + -LRB- hSKCa1 -RRB- channels expressed in HEK-293 cells .
23533263	0	tyrosine	75,83	EGFR	70,74	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	De-repression of PDGFRb transcription promotes acquired resistance to EGFR tyrosine kinase inhibitors in glioblastoma patients .
23551194	0	tyrosine	83,91	EGFR	70,74	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Molecular testing guideline for selection of lung_cancer patients for EGFR and ALK tyrosine kinase inhibitors : guideline from the College of American Pathologists , International Association for the Study of Lung_Cancer , and Association for Molecular Pathology .
23552377	0	tyrosine	83,91	EGFR	70,74	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Molecular testing guideline for selection of lung_cancer patients for EGFR and ALK tyrosine kinase inhibitors : guideline from the College of American Pathologists , International Association for the Study of Lung_Cancer , and Association for Molecular Pathology .
23559152	0	tyrosine	62,70	EGFR	164,168	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|mutations mutations|compound|END_ENTITY	Primary resistance to epidermal_growth_factor_receptor -LRB- EGFR -RRB- tyrosine kinase inhibitors -LRB- TKIs -RRB- in patients with non-small-cell_lung_cancer harboring TKI-sensitive EGFR mutations : an exploratory study .
23562183	0	tyrosine	83,91	EGFR	70,74	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Molecular testing guideline for selection of lung_cancer patients for EGFR and ALK tyrosine kinase inhibitors : guideline from the College of American Pathologists , International Association for the Study of Lung_Cancer , and Association for Molecular Pathology .
23588221	0	tyrosine	58,66	EGFR	53,57	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Knockdown of the Bcl-2 gene increases sensitivity to EGFR tyrosine kinase inhibitors in the H1975 lung_cancer cell line harboring T790M mutation .
23602524	0	tyrosine	133,141	EGFR	128,132	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Design , synthesis and biological evaluation of novel pyrimidine , 3-cyanopyridine and m-amino-N-phenylbenzamide based monocyclic EGFR tyrosine kinase inhibitors .
23668355	0	tyrosine	38,46	EGFR	33,37	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Computer-aided identification of EGFR tyrosine kinase inhibitors using ginsenosides from Panax_ginseng .
23674236	0	tyrosine	5,13	EGFR	0,4	tyrosine	EGFR	CHEBI:18186	1950	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	EGFR tyrosine kinase inhibitors : difference in efficacy and resistance .
23748900	0	tyrosine	100,108	EGFR	95,99	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	gefitinib|amod|START_ENTITY gefitinib|compound|END_ENTITY	Significant increase in hEGF uptake is correlated with formation of EGFR dimers induced by the EGFR tyrosine kinase inhibitor gefitinib .
23765757	0	tyrosine	125,133	EGFR	120,124	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|amod|END_ENTITY	EGFR-SGLT1 interaction does not respond to EGFR modulators , but inhibition of SGLT1 sensitizes prostate_cancer cells to EGFR tyrosine kinase inhibitors .
23789698	0	tyrosine	67,75	EGFR	62,66	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|amod|END_ENTITY	RECIST 1.1 in NSCLC patients with EGFR mutations treated with EGFR tyrosine kinase inhibitors : comparison with RECIST 1.0 .
23810573	0	tyrosine	5,13	EGFR	0,4	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	EGFR tyrosine kinase inhibitors beyond focal progression obtain a prolonged disease control in patients with advanced adenocarcinoma_of_the_lung .
23873621	0	tyrosine	48,56	EGFR	146,150	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|mutations mutations|amod|END_ENTITY	Sensitivity to epidermal_growth_factor_receptor tyrosine kinase inhibitors in males , smokers , and non-adenocarcinoma_lung_cancer in patients with EGFR mutations .
23974272	0	tyrosine	42,50	EGFR	37,41	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	response|amod|START_ENTITY response|compound|END_ENTITY	Solid predominant histology predicts EGFR tyrosine kinase inhibitor response in patients with EGFR mutation-positive lung_adenocarcinoma .
24072220	0	tyrosine	122,130	EGFR	117,121	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|amod|END_ENTITY	Chemotherapy with Erlotinib or chemotherapy alone in advanced non-small_cell_lung_cancer with acquired resistance to EGFR tyrosine kinase inhibitors .
24112466	0	tyrosine	89,97	EGFR	84,88	tyrosine	EGFR	CHEBI:18186	13649(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	A new gamboge derivative compound 2 inhibits cancer stem-like cells via suppressing EGFR tyrosine phosphorylation in head_and_neck_squamous_cell_carcinoma .
24192511	0	tyrosine	94,102	EGFR	124,128	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	A population-based review of the feasibility of platinum-based combination chemotherapy after tyrosine kinase inhibition in EGFR mutation positive non-small_cell_lung_cancer patients with advanced_disease .
24335842	0	tyrosine	79,87	EGFR	74,78	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Structure-based ensemble-QSAR model : a novel approach to the study of the EGFR tyrosine kinase and its inhibitors .
24376508	0	tyrosine	107,115	EGFR	102,106	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Predictive efficacy of low burden EGFR mutation detected by next-generation sequencing on response to EGFR tyrosine kinase inhibitors in non-small-cell_lung_carcinoma .
24399305	0	tyrosine	169,177	EGFR	164,168	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|amod|END_ENTITY	Synergistic cell growth inhibition by the combination of amrubicin and Akt-suppressing agents in K-ras mutation-harboring lung_adenocarcinoma cells : implication of EGFR tyrosine kinase inhibitors .
24631288	0	tyrosine	48,56	EGFR	134,138	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nmod|mutation mutation|nmod|END_ENTITY	Effect of simvastatin on the resistance to EGFR tyrosine kinase inhibitors in a non-small_cell_lung_cancer with the T790M mutation of EGFR .
24866341	0	tyrosine	101,109	EGFR	96,100	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Design and synthesis of quinazolinone tagged acridones as cytotoxic agents and their effects on EGFR tyrosine kinase .
24908327	0	tyrosine	27,35	EGFR	22,26	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|efficacy efficacy|nmod|END_ENTITY	Different efficacy of EGFR tyrosine kinase inhibitors and prognosis in patients with subtypes of EGFR-mutated advanced non-small_cell_lung_cancer : a meta-analysis .
25052479	0	tyrosine	55,63	EGFR	50,54	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Monitoring reversal of MET-mediated resistance to EGFR tyrosine kinase inhibitors in non-small_cell_lung_cancer using 3 ' - deoxy-3 ' - -LSB- 18F -RSB- - fluorothymidine positron emission tomography .
25057940	0	tyrosine	87,95	EGFR	82,86	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|amod|END_ENTITY	V843I , a lung_cancer predisposing EGFR mutation , is responsible for resistance to EGFR tyrosine kinase inhibitors .
25077897	0	tyrosine	74,82	EGFR	69,73	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|amod|END_ENTITY	The HSP90 inhibitor ganetespib potentiates the antitumor activity of EGFR tyrosine kinase inhibition in mutant and wild-type non-small_cell_lung_cancer .
25145405	0	tyrosine	24,32	EGFR	19,23	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|resistance resistance|nmod|END_ENTITY	Drug resistance to EGFR tyrosine kinase inhibitors for non-small_cell_lung_cancer .
25291939	0	tyrosine	41,49	EGFR	36,40	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|Correlation Correlation|nmod|efficacy efficacy|nmod|END_ENTITY	Correlation between efficacy of the EGFR tyrosine kinase inhibitor and serum tumor markers in lung_adenocarcinoma patients .
25338771	0	tyrosine	74,82	EGFR	69,73	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|amod|END_ENTITY	Usefulness of plasma HGF level for monitoring acquired resistance to EGFR tyrosine kinase inhibitors in non-small cell lung_cancer .
25498243	0	tyrosine	17,25	EGFR	12,16	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Efficacy of EGFR tyrosine kinase inhibitors in patients with EGFR-mutated non-small_cell_lung_cancer except both exon 19 deletion and exon 21 L858R : A retrospective analysis in Korea .
25510664	0	tyrosine	28,36	EGFR	23,27	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Acquired resistance to EGFR tyrosine kinase inhibitor in A431_squamous_cell_carcinoma xenografts is mediated by c-Kit pathway transduction .
25558790	0	tyrosine	65,73	EGFR	60,64	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	The impact of common and rare EGFR mutations in response to EGFR tyrosine kinase inhibitors and platinum-based chemotherapy in patients with non-small_cell_lung_cancer .
25583566	0	tyrosine	5,13	EGFR	0,4	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	EGFR tyrosine kinase inhibitors versus cranial radiation therapy for EGFR mutant non-small_cell_lung_cancer with brain metastases : A systematic review and meta-analysis .
25695284	0	tyrosine	104,112	EGFR	99,103	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Continuous exposure of non __ - small_cell_lung_cancer cells with wild - type EGFR to an inhibitor of EGFR tyrosine kinase induces chemoresistance by activating STAT3 .
25742484	0	tyrosine	28,36	EGFR	23,27	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|amod|END_ENTITY	Acquired resistance to EGFR tyrosine kinase inhibitors alters the metabolism of human head and neck squamous_carcinoma cells and xenograft tumours .
25806267	0	tyrosine	55,63	EGFR	50,54	tyrosine	EGFR	D014443	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	EGFR mutation heterogeneity and mixed response to EGFR tyrosine kinase inhibitors of non small cell lung_cancer : a clue to overcoming resistance .
25823662	0	tyrosine	62,70	EGFR	57,61	tyrosine	EGFR	D014443	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	MLH1 V384D polymorphism associates with poor response to EGFR tyrosine kinase inhibitors in patients with EGFR L858R-positive lung_adenocarcinoma .
25842092	0	tyrosine	150,158	EGFR	145,149	tyrosine	EGFR	D014443	1956	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|amod|END_ENTITY	Treatment of brain metastases in non-small_cell_lung_cancer -LRB- NSCLC -RRB- patients with epidermal_growth_factor_receptor -LRB- EGFR -RRB- mutations : the role of EGFR tyrosine kinase inhibitors .
25853020	0	tyrosine	74,82	EGFR	69,73	tyrosine	EGFR	CHEBI:18186	13649(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	A comparative PET imaging study with the reversible and irreversible EGFR tyrosine kinase inhibitors -LSB- -LRB- 11 -RRB- C -RSB- erlotinib and -LSB- -LRB- 18 -RRB- F -RSB- afatinib in lung_cancer-bearing mice .
25960661	1	tyrosine	185,193	EGFR	180,184	tyrosine	EGFR	D014443	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Non-small-cell_lung_cancer with epidermal_growth_factor_receptor -LRB- EGFR -RRB- mutation is sensitive to EGFR tyrosine kinase inhibitors -LRB- TKIs -RRB- .
25981168	0	tyrosine	25,33	EGFR	20,24	tyrosine	EGFR	D014443	1956	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|END_ENTITY	Combined effects of EGFR tyrosine kinase inhibitors and vATPase inhibitors in NSCLC cells .
26036637	0	tyrosine	5,13	EGFR	0,4	tyrosine	EGFR	D014443	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	EGFR tyrosine kinase inhibitors promote pro-caspase-8 dimerization that sensitizes cancer cells to DNA-damaging therapy .
26051233	0	tyrosine	24,32	EGFR	0,4	tyrosine	EGFR	D014443	1956	Chemical	Gene	START_ENTITY|nsubj|mutations mutations|amod|END_ENTITY	EGFR mutations and EGFR tyrosine kinase inhibitors .
26089022	0	tyrosine	139,147	EGFR	134,138	tyrosine	EGFR	D014443	13649(Tax:10090)	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Sequential use of vinorelbine followed by gefitinib enhances the antitumor effect in NSCLC cell lines poorly responsive to reversible EGFR tyrosine kinase inhibitors .
26172562	0	tyrosine	174,182	EGFR	169,173	tyrosine	EGFR	D014443	1956	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|amod|END_ENTITY	Continuation of epidermal growth factor receptor tyrosine kinase inhibitor treatment prolongs disease control in non-small-cell_lung_cancers with acquired resistance to EGFR tyrosine kinase inhibitors .
26175921	0	tyrosine	57,65	EGFR	52,56	tyrosine	EGFR	D014443	1956	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|amod|END_ENTITY	PD-L1 expression associated with better response to EGFR tyrosine kinase inhibitors .
26176330	0	tyrosine	115,123	EGFR	110,114	tyrosine	EGFR	D014443	1956	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|amod|END_ENTITY	The small GTPase ADP-Ribosylation_Factor_1 mediates the sensitivity of triple negative breast_cancer cells to EGFR tyrosine kinase inhibitors .
26236616	0	tyrosine	151,159	EGFR	146,150	tyrosine	EGFR	D014443	1956	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	A case of Trousseau_syndrome caused by pulmonary_adenocarcinoma that was controlled for one year and 10 months with thrombosis treatment using an EGFR tyrosine kinase inhibitor and chemotherapy .
26269114	0	tyrosine	175,183	EGFR	170,174	tyrosine	EGFR	D014443	1956	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|amod|END_ENTITY	Polymorphisms in epidermal_growth_factor_receptor -LRB- EGFR -RRB- and AKT1 as possible predictors of clinical outcome in advanced non-small-cell_lung_cancer patients treated with EGFR tyrosine kinase inhibitors .
26323212	0	tyrosine	83,91	EGFR	78,82	tyrosine	EGFR	D014443	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Impact of single nucleotide polymorphisms on severe hepatotoxicity induced by EGFR tyrosine kinase inhibitors in patients with non-small cell lung cancer harboring EGFR mutations .
26323212	0	tyrosine	83,91	EGFR	78,82	tyrosine	EGFR	D014443	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Impact of single nucleotide polymorphisms on severe hepatotoxicity induced by EGFR tyrosine kinase inhibitors in patients with non-small cell lung cancer harboring EGFR mutations .
26459407	1	tyrosine	278,286	EGFR	273,277	tyrosine	EGFR	D014443	1956	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|amod|END_ENTITY	BACKGROUND : Analysis of mutations in the epidermal_growth_factor_receptor gene -LRB- EGFR -RRB- is important for predicting response to EGFR tyrosine kinase inhibitors .
26579470	0	tyrosine	33,41	EGFR	28,32	tyrosine	EGFR	D014443	1956	Chemical	Gene	START_ENTITY|nsubj|Mechanisms Mechanisms|nmod|resistance resistance|nmod|END_ENTITY	Mechanisms of resistance to EGFR tyrosine kinase inhibitors .
26629062	0	tyrosine	35,43	EGFR	30,34	tyrosine	EGFR	D014443	1956	Chemical	Gene	inhibitor|compound|START_ENTITY inhibitor|compound|END_ENTITY	Phase I study of icotinib , an EGFR tyrosine kinase inhibitor combined with IMRT in nasopharyngeal_carcinoma .
26745678	0	tyrosine	45,53	EGFR	40,44	tyrosine	EGFR	D014443	1956	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|amod|END_ENTITY	TOPK promotes lung_cancer resistance to EGFR tyrosine kinase inhibitors by phosphorylating and activating c-Jun .
26836897	0	tyrosine	17,25	EGFR	12,16	tyrosine	EGFR	D014443	1956	Chemical	Gene	START_ENTITY|nsubj|Efficacy Efficacy|nmod|END_ENTITY	Efficacy of EGFR tyrosine kinase inhibitors in the adjuvant treatment for operable non-small-cell_lung_cancer by a meta-analysis .
26942444	0	tyrosine	17,25	EGFR	12,16	tyrosine	EGFR	D014443	1956	Chemical	Gene	START_ENTITY|nsubj|Efficacy Efficacy|nmod|END_ENTITY	Efficacy of EGFR tyrosine kinase inhibitors for non-adenocarcinoma lung_cancer patients harboring EGFR-sensitizing mutations in China .
26950414	0	tyrosine	37,45	EGFR	32,36	tyrosine	EGFR	D014443	1956	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	Rociletinib , a third generation EGFR tyrosine kinase inhibitor : current data and future directions .
26977054	0	tyrosine	108,116	EGFR	103,107	tyrosine	EGFR	D014443	1956	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|amod|END_ENTITY	Characteristics and overall survival of EGFR mutation-positive non-small_cell_lung_cancer treated with EGFR tyrosine kinase inhibitors : a retrospective analysis for 1660 Japanese patients .
27022274	0	tyrosine	24,32	EGFR	19,23	tyrosine	EGFR	D014443	1956	Chemical	Gene	START_ENTITY|nsubj|action action|nmod|END_ENTITY	Combined action of EGFR tyrosine kinase inhibitors and whole-brain radiotherapy on EGFR-mutated non-small-cell lung_cancer patients with brain metastasis .
27040855	0	tyrosine	38,46	EGFR	67,71	tyrosine	EGFR	D014443	1956	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|nmod|END_ENTITY	BE-POSITIVE : Beyond progression after tyrosine kinase inhibitor in EGFR - positive non_small_cell_lung_cancer patients : Results from a multicenter Italian observational study .
27057666	0	tyrosine	12,20	EGFR	7,11	tyrosine	EGFR	D014443	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Should EGFR tyrosine kinase inhibitors be used in non-small_cell_lung_cancer in the absence of EGFR mutations ?
27057667	0	tyrosine	12,20	EGFR	7,11	tyrosine	EGFR	D014443	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Should EGFR tyrosine kinase inhibitors be used in non-small_cell_lung_cancer in the absence of EGFR mutations ?
9294612	0	tyrosine	96,104	EGFR	91,95	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Radiation-induced proliferation of the human A431 squamous_carcinoma cells is dependent on EGFR tyrosine phosphorylation .
9716460	6	tyrosine	989,997	EGFR	984,988	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	When surface-bound TGFalpha was removed by acid stripping and endosomal pH was neutralized with bafilomycin_A1 , TGFalpha stimulated EGFR tyrosine phosphorylation , induced p21/CIP1 , and inhibited DNA synthesis .
11352831	0	tyrosine	21,29	EGF_receptor	8,20	tyrosine	EGF receptor	CHEBI:18186	13649(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of EGF_receptor tyrosine kinase activity in antiapoptotic effect of EGF on mouse hepatocytes .
15623600	0	tyrosine	132,140	EGF_receptor	119,131	tyrosine	EGF receptor	CHEBI:18186	1956	Chemical	Gene	inhibitor|compound|START_ENTITY inhibitor|compound|END_ENTITY	Coexpression of matrix_metalloproteinase-7 -LRB- MMP-7 -RRB- and epidermal_growth_factor _ -LRB- EGF -RRB- _ receptor in colorectal_cancer : an EGF_receptor tyrosine kinase inhibitor is effective against MMP-7-expressing cancer cells .
20388507	0	tyrosine	45,53	EGF_receptor	32,44	tyrosine	EGF receptor	CHEBI:18186	1956	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|compound|END_ENTITY	Neuromedin_B receptors regulate EGF_receptor tyrosine phosphorylation in lung_cancer cells .
20477246	0	tyrosine	27,35	EGF_receptor	14,26	tyrosine	EGF receptor	CHEBI:18186	1956	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	Erlotinib : an EGF_receptor tyrosine kinase inhibitor in non-small-cell lung_cancer treatment .
23172312	0	tyrosine	40,48	EGF_receptor	27,39	tyrosine	EGF receptor	CHEBI:18186	1956	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Resistance to irreversible EGF_receptor tyrosine kinase inhibitors through a multistep mechanism involving the IGF1R pathway .
2464783	0	tyrosine	19,27	EGF_receptor	47,59	tyrosine	EGF receptor	CHEBI:18186	1956	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Ligand-independent tyrosine phosphorylation of EGF_receptor and the erbB-2 / neu proto-oncogene product is induced by hyperosmotic_shock .
25675121	0	tyrosine	35,43	EGF_receptor	22,34	tyrosine	EGF receptor	CHEBI:18186	1956	Chemical	Gene	inhibitor|compound|START_ENTITY inhibitor|compound|END_ENTITY	Icotinib , a selective EGF_receptor tyrosine kinase inhibitor , for the treatment of non-small-cell_lung_cancer .
8106561	0	tyrosine	142,150	EGF_receptor	129,141	tyrosine	EGF receptor	CHEBI:18186	1956	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Loss of cytotoxic effect of epidermal_growth_factor -LRB- EGF -RRB- on EGF_receptor overexpressing cells is associated with attenuation of EGF_receptor tyrosine kinase activity .
8625444	0	tyrosine	64,72	EGF_receptor	51,63	tyrosine	EGF receptor	CHEBI:18186	24329(Tax:10116)	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Azoxymethane enhances ligand-induced activation of EGF_receptor tyrosine kinase in the colonic mucosa of rats .
8960549	2	tyrosine	97,105	EGF_receptor	84,96	tyrosine	EGF receptor	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Dimeric benzylidenemalononitrile tyrophostins : potent inhibitors of EGF_receptor tyrosine kinase in vitro .
10663641	0	tyrosine	45,53	EGFr	40,44	tyrosine	EGFr	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Anticancer efficacy of the irreversible EGFr tyrosine kinase inhibitor PD_0169414 against human tumor xenografts .
9191074	0	tyrosine	66,74	EHK-1	51,56	tyrosine	EHK-1	CHEBI:18186	2044	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Extensive splice variation and localization of the EHK-1 receptor tyrosine kinase in adult human brain and glial_tumors .
15952790	0	tyrosine	18,26	ELMO1	39,44	tyrosine	ELMO1	CHEBI:18186	9844	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Identification of tyrosine residues on ELMO1 that are phosphorylated by the Src-family kinase Hck .
22137457	0	tyrosine	82,90	EPHA4	67,72	tyrosine	EPHA4	CHEBI:18186	2043	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Fragment based lead discovery of small molecule inhibitors for the EPHA4 receptor tyrosine kinase .
23100466	0	tyrosine	31,39	EPHB4	47,52	tyrosine	EPHB4	D014443	2050	Chemical	Gene	role|nmod|START_ENTITY kinase|nsubj|role kinase|dobj|END_ENTITY	Critical role for the receptor tyrosine kinase EPHB4 in esophageal_cancers .
25391996	0	tyrosine	33,41	EPHB4	18,23	tyrosine	EPHB4	CHEBI:18186	2050	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Expression of the EPHB4 receptor tyrosine kinase in head and neck and renal_malignancies - implications for solid tumors and potential for therapeutic inhibition .
19513565	0	tyrosine	36,44	EPHB6	21,26	tyrosine	EPHB6	CHEBI:18186	2051	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The kinase defective EPHB6 receptor tyrosine kinase activates MAP kinase signaling in lung_adenocarcinoma .
20371680	0	tyrosine	19,27	EPHB6	4,9	tyrosine	EPHB6	CHEBI:18186	2051	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The EPHB6 receptor tyrosine kinase is a metastasis suppressor that is frequently silenced by promoter DNA hypermethylation in non-small cell lung_cancer .
14747462	0	tyrosine	107,115	ER81	36,40	tyrosine	ER81	CHEBI:18186	2115	Chemical	Gene	START_ENTITY|nsubj|activation activation|nmod|END_ENTITY	Concerted activation of ETS protein ER81 by p160 coactivators , the acetyltransferase p300 and the receptor tyrosine kinase HER2/Neu .
12947392	0	tyrosine	14,22	ERBB	0,4	tyrosine	ERBB	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|receptor receptor|compound|END_ENTITY	ERBB receptor tyrosine kinases and cellular radiation responses .
20564646	0	tyrosine	27,35	ERBB	13,17	tyrosine	ERBB	CHEBI:18186	1956	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Signaling of ERBB receptor tyrosine kinases promotes neuroblastoma growth in vitro and in vivo .
16299242	0	tyrosine	75,83	ERBB2	131,136	tyrosine	ERBB2	CHEBI:18186	2064	Chemical	Gene	inhibitors|amod|START_ENTITY epidermal_growth_factor_receptor|dobj|inhibitors head_and_neck_cancers|acl|epidermal_growth_factor_receptor Response|nmod|head_and_neck_cancers linked|nsubjpass|Response linked|nmod|mutation mutation|nmod|END_ENTITY	Response of some head_and_neck_cancers to epidermal_growth_factor_receptor tyrosine kinase inhibitors may be linked to mutation of ERBB2 rather than EGFR .
17150109	0	tyrosine	24,32	ERBB2	50,55	tyrosine	ERBB2	CHEBI:18186	2064	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	A novel mutation in the tyrosine kinase domain of ERBB2 in hepatocellular_carcinoma .
20932292	1	tyrosine	160,168	ERBB2	103,108	tyrosine	ERBB2	CHEBI:18186	2064	Chemical	Gene	receptor|compound|START_ENTITY gene|nmod|receptor gene|compound|END_ENTITY	BACKGROUND : Around 20 % of breast_cancers -LRB- BC -RRB- show ERBB2 gene amplification and overexpression of the ERBB2 tyrosine kinase receptor .
22908275	0	tyrosine	32,40	ERBB2	128,133	tyrosine	ERBB2	CHEBI:18186	2064	Chemical	Gene	mutations|compound|START_ENTITY analysis|nmod|mutations identifies|nsubj|analysis identifies|dobj|mutations mutations|nmod|END_ENTITY	Functional analysis of receptor tyrosine kinase mutations in lung_cancer identifies oncogenic extracellular domain mutations of ERBB2 .
25590338	0	tyrosine	9,17	ERBB2	63,68	tyrosine	ERBB2	D014443	2064	Chemical	Gene	START_ENTITY|ccomp|acquired acquired|nmod|inhibitors inhibitors|nummod|END_ENTITY	Receptor tyrosine kinase ERBB4 mediates acquired resistance to ERBB2 inhibitors in breast_cancer cells .
7903276	0	tyrosine	18,26	ERK	58,61	tyrosine	ERK	CHEBI:18186	5594	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Concurrent strong tyrosine phosphorylation of a 42,000 MW ERK and a 100,000 MW protein is associated with IL-2 production in human Jurkat T cells .
9281348	0	tyrosine	32,40	ERK1	72,76	tyrosine	ERK1	CHEBI:18186	5595	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Cell-matrix interactions induce tyrosine phosphorylation of MAP kinases ERK1 and ERK2 and PLCgamma-1 in two-dimensional and three-dimensional cultures of human fibroblasts .
16305985	0	tyrosine	31,39	ERK1/2	18,24	tyrosine	ERK1/2	CHEBI:18186	5595;5594	Chemical	Gene	kinase|amod|START_ENTITY END_ENTITY|nmod|kinase	The activation of ERK1/2 via a tyrosine kinase pathway attenuates trail-induced apoptosis in HeLa cells .
18483257	0	tyrosine	17,25	ERalpha	73,80	tyrosine	ERalpha	CHEBI:18186	2099	Chemical	Gene	START_ENTITY|nmod|pathway pathway|compound|END_ENTITY	The Ret receptor tyrosine kinase pathway functionally interacts with the ERalpha pathway in breast_cancer .
24606948	0	tyrosine	27,35	ETK/BMX	43,50	tyrosine	ETK/BMX	CHEBI:18186	660	Chemical	Gene	expression|nmod|START_ENTITY kinase|nsubj|expression kinase|dobj|END_ENTITY	The expression and role of tyrosine kinase ETK/BMX in renal_cell_carcinoma .
10880758	0	tyrosine	14,22	ETK2	0,4	tyrosine	ETK2	CHEBI:18186	22174(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	ETK2 receptor tyrosine kinase promotes survival of factor-dependent FDC-P1 progenitor cells .
7982920	0	tyrosine	39,47	Eck	18,21	tyrosine	Eck	CHEBI:18186	13836(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity .
8183555	0	tyrosine	17,25	Eck	4,7	tyrosine	Eck	CHEBI:18186	13836(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The Eck receptor tyrosine kinase is implicated in pattern formation during gastrulation , hindbrain segmentation and limb development .
20717963	0	tyrosine	16,24	Emi1	44,48	tyrosine	Emi1	CHEBI:18186	26271	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Bcr-Abl-induced tyrosine phosphorylation of Emi1 to stabilize Skp2 protein via inhibition of ubiquitination in chronic_myeloid_leukemia cells .
10048424	0	tyrosine	10,18	Emt	6,9	tyrosine	Emt	CHEBI:18186	3702	Chemical	Gene	kinase|amod|START_ENTITY END_ENTITY|amod|kinase	Human Emt tyrosine kinase is specifically expressed both in mature T-lymphocytes and T-cell associated hematopoietic_malignancies .
1334998	0	tyrosine	24,32	Endothelin-1	0,12	tyrosine	Endothelin-1	CHEBI:18186	1906	Chemical	Gene	phosphorylation|amod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Endothelin-1 stimulates tyrosine phosphorylation and the activities of two mitogen-activated protein kinases in cultured vascular smooth muscle cells .
8589330	0	tyrosine	24,32	Endothelin-1	0,12	tyrosine	Endothelin-1	CHEBI:18186	13614(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Endothelin-1 stimulates tyrosine phosphorylation of p125 focal adhesion kinase in mesangial cells .
8813707	0	tyrosine	21,29	Endothelin-1	0,12	tyrosine	Endothelin-1	CHEBI:18186	1906	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Endothelin-1 induces tyrosine phosphorylation in human blood monocytes .
12907451	0	tyrosine	52,60	Eph	39,42	tyrosine	Eph	CHEBI:18186	2041	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Human dendritic cells express neuronal Eph receptor tyrosine kinases : role of EphA2 in regulating adhesion to fibronectin .
16977320	0	tyrosine	77,85	Eph	64,67	tyrosine	Eph	CHEBI:18186	2041	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	A change in conformational dynamics underlies the activation of Eph receptor tyrosine kinases .
21439481	0	tyrosine	29,37	Eph	16,19	tyrosine	Eph	CHEBI:18186	2041	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	A semisynthetic Eph receptor tyrosine kinase provides insight into ligand-induced kinase activation .
22588054	0	tyrosine	74,82	Eph	61,64	tyrosine	Eph	CHEBI:18186	2041	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Regulation of tumor initiation and metastatic progression by Eph receptor tyrosine kinases .
7634326	0	tyrosine	118,126	Eph	105,108	tyrosine	Eph	CHEBI:18186	2041	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	In vitro guidance of retinal ganglion cell axons by RAGS , a 25 kDa tectal protein related to ligands for Eph receptor tyrosine kinases .
9053851	0	tyrosine	48,56	Eph	34,37	tyrosine	Eph	CHEBI:18186	13835(Tax:10090)	Chemical	Gene	kinases|amod|START_ENTITY family|nmod|kinases family|compound|END_ENTITY	The Eek receptor , a member of the Eph family of tyrosine protein kinases , can be activated by three different Eph family ligands .
21503576	0	tyrosine	60,68	EphA1	88,93	tyrosine	EphA1	CHEBI:18186	2041	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Sesamin induces autophagy in colon_cancer cells by reducing tyrosine phosphorylation of EphA1 and EphB2 .
15777695	0	tyrosine	41,49	EphA10	58,64	tyrosine	EphA10	CHEBI:18186	284656	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	Characterization of a novel Eph receptor tyrosine kinase , EphA10 , expressed in testis .
10511313	0	tyrosine	56,64	EphA2	41,46	tyrosine	EphA2	CHEBI:18186	1969	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	E-cadherin regulates the function of the EphA2 receptor tyrosine kinase .
11968011	0	tyrosine	61,69	EphA2	55,60	tyrosine	EphA2	CHEBI:18186	1969	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Estrogen and Myc negatively regulate expression of the EphA2 tyrosine kinase .
12019162	0	tyrosine	32,40	EphA2	26,31	tyrosine	EphA2	CHEBI:18186	1969	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Antibody targeting of the EphA2 tyrosine kinase inhibits malignant cell behavior .
15054110	0	tyrosine	15,23	EphA2	0,5	tyrosine	EphA2	CHEBI:18186	13836(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	EphA2 receptor tyrosine kinase regulates endothelial cell migration and vascular assembly through phosphoinositide 3-kinase-mediated Rac1 GTPase activation .
16051609	0	tyrosine	53,61	EphA2	47,52	tyrosine	EphA2	CHEBI:18186	1969	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|amod|END_ENTITY	EphrinA1 repulsive response is regulated by an EphA2 tyrosine phosphatase .
16849550	0	tyrosine	29,37	EphA2	14,19	tyrosine	EphA2	CHEBI:18186	13836(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Disruption of EphA2 receptor tyrosine kinase leads to increased susceptibility to carcinogenesis in mouse skin .
18079969	0	tyrosine	13,21	EphA2	29,34	tyrosine	EphA2	CHEBI:18186	13836(Tax:10090)	Chemical	Gene	START_ENTITY|ccomp|promotes promotes|nsubj|END_ENTITY	The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma_tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling .
19089910	0	tyrosine	23,31	EphA2	8,13	tyrosine	EphA2	CHEBI:18186	13836(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Loss of EphA2 receptor tyrosine kinase reduces ApcMin / + tumorigenesis .
19321667	0	tyrosine	70,78	EphA2	55,60	tyrosine	EphA2	CHEBI:18186	1969	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Regulation of mammary gland branching morphogenesis by EphA2 receptor tyrosine kinase .
22916121	0	tyrosine	43,51	EphA2	28,33	tyrosine	EphA2	CHEBI:18186	1969	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	A small molecule agonist of EphA2 receptor tyrosine kinase inhibits tumor cell migration in vitro and prostate_cancer metastasis in vivo .
24733396	0	tyrosine	124,132	EphA2	109,114	tyrosine	EphA2	CHEBI:18186	1969	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Point mutations in dimerization motifs of the transmembrane domain stabilize active or inactive state of the EphA2 receptor tyrosine kinase .
22242939	0	tyrosine	65,73	EphA3	50,55	tyrosine	EphA3	CHEBI:18186	2042	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Cancer somatic mutations disrupt functions of the EphA3 receptor tyrosine kinase through multiple mechanisms .
10887087	0	tyrosine	23,31	EphA4	17,22	tyrosine	EphA4	CHEBI:18186	13838(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Targeting of the EphA4 tyrosine kinase receptor affects dorsal/ventral pathfinding of limb motor axons .
11085874	0	tyrosine	19,27	EphA4	4,9	tyrosine	EphA4	CHEBI:18186	2043	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	The EphA4 receptor tyrosine kinase is necessary for the guidance of nasal retinal ganglion cell axons in vitro .
17030822	0	tyrosine	4,12	EphA4	29,34	tyrosine	EphA4	CHEBI:18186	13838(Tax:10090)	Chemical	Gene	START_ENTITY|ccomp|required required|nsubjpass|END_ENTITY	Eph tyrosine kinase receptor EphA4 is required for the topographic mapping of the corticospinal tract .
18422655	0	tyrosine	27,35	EphA4	12,17	tyrosine	EphA4	CHEBI:18186	2043	Chemical	Gene	START_ENTITY|nsubj|Analysis Analysis|nmod|receptor receptor|amod|END_ENTITY	Analysis of EphA4 receptor tyrosine kinase substrate specificity using peptide-based arrays .
22036717	0	tyrosine	39,47	EphA4	25,30	tyrosine	EphA4	CHEBI:18186	2043	Chemical	Gene	START_ENTITY|nsubj|structure structure|nmod|protein protein|amod|END_ENTITY	Crystal structure of the EphA4 protein tyrosine kinase domain in the apo - and dasatinib-bound state .
23390555	0	tyrosine	15,23	EphA4	0,5	tyrosine	EphA4	CHEBI:18186	13838(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	EphA4 receptor tyrosine kinase is a modulator of onset and disease severity of experimental_autoimmune_encephalomyelitis -LRB- EAE -RRB- .
23959867	0	tyrosine	27,35	EphA4	85,90	tyrosine	EphA4	CHEBI:18186	2043	Chemical	Gene	START_ENTITY|nmod|structures structures|nmod|ectodomain ectodomain|amod|END_ENTITY	Insights into Eph receptor tyrosine kinase activation from crystal structures of the EphA4 ectodomain and its complex with ephrin-A5 .
9401744	0	tyrosine	35,43	EphA4	51,56	tyrosine	EphA4	CHEBI:18186	316539(Tax:10116)	Chemical	Gene	START_ENTITY|ccomp|rat rat|nsubj|END_ENTITY	Immunolocalization of the receptor tyrosine kinase EphA4 in the adult rat central nervous system .
9425139	0	tyrosine	51,59	EphA4	28,33	tyrosine	EphA4	CHEBI:18186	13838(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Segmental expression of the EphA4 -LRB- Sek-1 -RRB- receptor tyrosine kinase in the hindbrain is under direct transcriptional control of Krox-20 .
9789074	0	tyrosine	22,30	EphA4	0,5	tyrosine	EphA4	CHEBI:18186	13838(Tax:10090)	Chemical	Gene	kinase|amod|START_ENTITY receptor|amod|kinase receptor|amod|END_ENTITY	EphA4 -LRB- Sek1 -RRB- receptor tyrosine kinase is required for the development of the corticospinal tract .
17952132	0	tyrosine	18,26	EphA5	43,48	tyrosine	EphA5	CHEBI:18186	13839(Tax:10090)	Chemical	Gene	Expression|nmod|START_ENTITY kinase|nsubj|Expression kinase|dobj|END_ENTITY	Expression of the tyrosine kinase receptor EphA5 and its ligand ephrin-A5 during mouse spinal cord development .
16723736	0	tyrosine	78,86	EphB1	63,68	tyrosine	EphB1	CHEBI:18186	2047	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Caveolin-1 is required for signaling and membrane targeting of EphB1 receptor tyrosine kinase .
11585923	0	tyrosine	89,97	EphB2	74,79	tyrosine	EphB2	CHEBI:18186	2048	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Downregulation of the Ras-mitogen-activated protein kinase pathway by the EphB2 receptor tyrosine kinase is required for ephrin-induced neurite retraction .
17249693	0	tyrosine	86,94	EphB2	80,85	tyrosine	EphB2	CHEBI:18186	2048	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Cupredoxin-cancer interrelationship : azurin binding with EphB2 , interference in EphB2 tyrosine phosphorylation , and inhibition of cancer growth .
25784101	0	tyrosine	13,21	EphB2	29,34	tyrosine	EphB2	D014443	13844(Tax:10090)	Chemical	Gene	START_ENTITY|ccomp|promotes promotes|nsubj|END_ENTITY	The receptor tyrosine kinase EphB2 promotes hepatic fibrosis in mice .
15536074	0	tyrosine	127,135	EphB3	112,117	tyrosine	EphB3	CHEBI:18186	2049	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Inhibition of integrin-mediated cell adhesion but not directional cell migration requires catalytic activity of EphB3 receptor tyrosine kinase .
11801721	0	tyrosine	122,130	EphB4	107,112	tyrosine	EphB4	CHEBI:18186	13846(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Altered mammary epithelial development , pattern formation and involution in transgenic_mice expressing the EphB4 receptor tyrosine kinase .
12676328	0	tyrosine	15,23	EphB4	0,5	tyrosine	EphB4	CHEBI:18186	13846(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|receptor receptor|amod|END_ENTITY	EphB4 receptor tyrosine kinase transgenic_mice develop glomerulopathies reminiscent of aglomerular vascular shunts .
16205642	0	tyrosine	15,23	EphB4	0,5	tyrosine	EphB4	CHEBI:18186	13846(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	EphB4 receptor tyrosine kinase is expressed in bladder_cancer and provides signals for cell survival .
23844053	0	tyrosine	19,27	EphB4	4,9	tyrosine	EphB4	CHEBI:18186	2050	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	The EphB4 receptor tyrosine kinase promotes lung_cancer growth : a potential novel therapeutic target .
25886373	0	tyrosine	30,38	EphB4	47,52	tyrosine	EphB4	D014443	2050	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	The tumour-promoting receptor tyrosine kinase , EphB4 , regulates expression of Integrin-b8 in prostate_cancer cells .
11519828	0	tyrosine	39,47	Epha1	24,29	tyrosine	Epha1	CHEBI:18186	2041	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Characterization of the Epha1 receptor tyrosine kinase : expression in epithelial tissues .
16466970	0	tyrosine	42,50	Epha1	27,32	tyrosine	Epha1	CHEBI:18186	13835(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Expression analysis of the Epha1 receptor tyrosine kinase and its high-affinity ligands Efna1 and Efna3 during early mouse development .
18694808	0	tyrosine	17,25	EphrinB2	0,8	tyrosine	EphrinB2	CHEBI:18186	306636(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	EphrinB2 induces tyrosine phosphorylation of NR2B via Src-family kinases during inflammatory hyperalgesia .
1696547	0	tyrosine	32,40	Epidermal_growth_factor	0,23	tyrosine	Epidermal growth factor	CHEBI:18186	1950	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Epidermal_growth_factor induces tyrosine phosphorylation of epidermal_growth_factor_receptors not occupied with ligand in intact A431 cells .
3107554	0	tyrosine	35,43	Epidermal_growth_factor	0,23	tyrosine	Epidermal growth factor	CHEBI:18186	1950	Chemical	Gene	phosphorylation|amod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Epidermal_growth_factor stimulates tyrosine phosphorylation of human glucocorticoid_receptor in cultured cells .
3328613	0	tyrosine	53,61	Epidermal_growth_factor	0,23	tyrosine	Epidermal growth factor	CHEBI:18186	1950	Chemical	Gene	phosphorylation|amod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Epidermal_growth_factor , but not insulin , stimulates tyrosine phosphorylation of an endogenous protein of Mr 95,000 in triton extracts of human placental syncytiotrophoblast membranes .
3877722	0	tyrosine	35,43	Epidermal_growth_factor	0,23	tyrosine	Epidermal growth factor	CHEBI:18186	1950	Chemical	Gene	phosphorylation|amod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Epidermal_growth_factor stimulates tyrosine phosphorylation of specific proteins in permeabilized human fibroblasts .
6166387	0	tyrosine	38,46	Epidermal_growth_factor	0,23	tyrosine	Epidermal growth factor	CHEBI:18186	1950	Chemical	Gene	phosphorylation|compound|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Epidermal_growth_factor induces rapid tyrosine phosphorylation of proteins in A431 human tumor cells .
7508718	0	tyrosine	32,40	Epidermal_growth_factor	0,23	tyrosine	Epidermal growth factor	CHEBI:18186	1950	Chemical	Gene	START_ENTITY|nsubj|induced induced|compound|END_ENTITY	Epidermal_growth_factor induced tyrosine phosphorylation of nuclear proteins associated with translocation of epidermal_growth_factor_receptor into the nucleus .
7538664	0	tyrosine	36,44	Epidermal_growth_factor	0,23	tyrosine	Epidermal growth factor	CHEBI:18186	13645(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Epidermal_growth_factor induces the tyrosine phosphorylation and nuclear translocation of Stat_5 in mouse liver .
7542259	0	tyrosine	32,40	Epidermal_growth_factor	0,23	tyrosine	Epidermal growth factor	CHEBI:18186	1950	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Epidermal_growth_factor induces tyrosine phosphorylation and reorganization of the tight junction protein ZO-1 in A431 cells .
7681824	0	tyrosine	39,47	Epidermal_growth_factor	0,23	tyrosine	Epidermal growth factor	CHEBI:18186	13645(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Epidermal_growth_factor stimulates the tyrosine phosphorylation of SHC in the mouse .
7926013	0	tyrosine	40,48	Epidermal_growth_factor	0,23	tyrosine	Epidermal growth factor	CHEBI:18186	1950	Chemical	Gene	phosphorylation|compound|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Epidermal_growth_factor induces protein tyrosine phosphorylation and association of p190 with ras-GTP-ase activating protein in Caco-2 cells .
9344856	0	tyrosine	39,47	Epidermal_growth_factor	0,23	tyrosine	Epidermal growth factor	CHEBI:18186	1950	Chemical	Gene	phosphorylation|amod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Epidermal_growth_factor stimulates the tyrosine phosphorylation of SHPS-1 and association of SHPS-1 with SHP-2 , a SH2 domain-containing protein tyrosine phosphatase .
12604628	0	tyrosine	33,41	Epidermal_growth_factor-receptor	0,32	tyrosine	Epidermal growth factor-receptor	CHEBI:18186	1956	Chemical	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Epidermal_growth_factor-receptor tyrosine kinase activity regulates expansion of porcine oocyte-cumulus cell complexes in vitro .
10766863	0	tyrosine	33,41	Epidermal_growth_factor_receptor	0,32	tyrosine	Epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Epidermal_growth_factor_receptor tyrosine kinase mediates Ras activation by gonadotropin-releasing_hormone .
12447985	0	tyrosine	33,41	Epidermal_growth_factor_receptor	0,32	tyrosine	Epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Epidermal_growth_factor_receptor tyrosine kinase inhibitors -LRB- EGFR-TKIs -RRB- : simple drugs with a complex mechanism of action ?
12941834	0	tyrosine	33,41	Epidermal_growth_factor_receptor	0,32	tyrosine	Epidermal growth factor receptor	CHEBI:18186	13649(Tax:10090)	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|compound|END_ENTITY	Epidermal_growth_factor_receptor tyrosine kinase inhibition augments a murine model of pulmonary_fibrosis .
15025409	0	tyrosine	33,41	Epidermal_growth_factor_receptor	0,32	tyrosine	Epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Epidermal_growth_factor_receptor tyrosine kinase inhibitors : application in non-small cell lung_cancer .
15496147	0	tyrosine	33,41	Epidermal_growth_factor_receptor	0,32	tyrosine	Epidermal growth factor receptor	CHEBI:18186	24329(Tax:10116)	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|compound|END_ENTITY	Epidermal_growth_factor_receptor tyrosine kinase inhibition is not protective in PCK rats .
15623645	0	tyrosine	33,41	Epidermal_growth_factor_receptor	0,32	tyrosine	Epidermal growth factor receptor	CHEBI:18186	13649(Tax:10090)	Chemical	Gene	inhibitor|compound|START_ENTITY inhibitor|compound|END_ENTITY	Epidermal_growth_factor_receptor tyrosine kinase inhibitor does not improve paclitaxel effect in an orthotopic mouse model of lung_cancer .
15756277	0	tyrosine	55,63	Epidermal_growth_factor_receptor	0,32	tyrosine	Epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitor|amod|START_ENTITY targeting|nmod|inhibitor double|xcomp|targeting double|nsubj|END_ENTITY	Epidermal_growth_factor_receptor double targeting by a tyrosine kinase inhibitor -LRB- Iressa -RRB- and a monoclonal antibody -LRB- Cetuximab -RRB- .
16601275	0	tyrosine	33,41	Epidermal_growth_factor_receptor	0,32	tyrosine	Epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|amod|END_ENTITY	Epidermal_growth_factor_receptor tyrosine kinase inhibitors and bone metastases : different mechanisms of action for a novel therapeutic application ?
16672372	0	tyrosine	96,104	Epidermal_growth_factor_receptor	0,32	tyrosine	Epidermal growth factor receptor	CHEBI:18186	13649(Tax:10090)	Chemical	Gene	variant|advcl|START_ENTITY variant|nsubj|END_ENTITY	Epidermal_growth_factor_receptor variant III mutations in lung tumorigenesis and sensitivity to tyrosine kinase inhibitors .
16764754	0	tyrosine	33,41	Epidermal_growth_factor_receptor	0,32	tyrosine	Epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Epidermal_growth_factor_receptor tyrosine kinase inhibitors in lung_cancer : impact of primary or secondary mutations .
17101784	0	tyrosine	59,67	Epidermal_growth_factor_receptor	0,32	tyrosine	Epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	sites|compound|START_ENTITY controlled|nmod|sites controlled|nsubjpass|fate fate|amod|END_ENTITY	Epidermal_growth_factor_receptor fate is controlled by Hrs tyrosine phosphorylation sites that regulate Hrs degradation .
17142315	0	tyrosine	33,41	Epidermal_growth_factor_receptor	0,32	tyrosine	Epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Epidermal_growth_factor_receptor tyrosine kinase is modulated by GM3 interaction with N-linked GlcNAc termini of the receptor .
17551677	0	tyrosine	33,41	Epidermal_growth_factor_receptor	0,32	tyrosine	Epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Epidermal_growth_factor_receptor tyrosine kinase inhibitors for the treatment of non-small-cell_lung_cancer : results and open issues .
18042729	0	tyrosine	75,83	Epidermal_growth_factor_receptor	0,32	tyrosine	Epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	activation|amod|START_ENTITY regulates|dobj|activation regulates|nsubj|region region|amod|END_ENTITY	Epidermal_growth_factor_receptor juxtamembrane region regulates allosteric tyrosine kinase activation .
18926838	0	tyrosine	79,87	Epidermal_growth_factor_receptor	0,32	tyrosine	Epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibition|amod|START_ENTITY mediated|nmod|inhibition mediated|nsubjpass|activation activation|amod|END_ENTITY	Epidermal_growth_factor_receptor activation by diesel particles is mediated by tyrosine phosphatase inhibition .
19154417	0	tyrosine	163,171	Epidermal_growth_factor_receptor	0,32	tyrosine	Epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitor|amod|START_ENTITY epidermal_growth_factor_receptor|dobj|inhibitor retains|xcomp|epidermal_growth_factor_receptor retains|nsubj|END_ENTITY	Epidermal_growth_factor_receptor lacking C-terminal autophosphorylation sites retains signal transduction and high sensitivity to epidermal_growth_factor_receptor tyrosine kinase inhibitor .
19430813	0	tyrosine	79,87	Epidermal_growth_factor_receptor	0,32	tyrosine	Epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinase|amod|START_ENTITY therapy|amod|kinase receiving|dobj|therapy patients|acl|receiving variation|nmod|patients variation|amod|END_ENTITY	Epidermal_growth_factor_receptor genomic variation in NSCLC patients receiving tyrosine kinase inhibitor therapy : a systematic review and meta-analysis .
19825949	0	tyrosine	33,41	Epidermal_growth_factor_receptor	0,32	tyrosine	Epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitor|compound|START_ENTITY inhibitor|compound|END_ENTITY	Epidermal_growth_factor_receptor tyrosine kinase inhibitor reverses mesenchymal to epithelial phenotype and inhibits metastasis in inflammatory breast_cancer .
21411993	0	tyrosine	191,199	Epidermal_growth_factor_receptor	0,32	tyrosine	Epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|mutations mutations|amod|END_ENTITY	Epidermal_growth_factor_receptor mutations as a prognostic factor in Korean patients with advanced lung_adenocarcinoma who had not been treated with received epidermal_growth_factor_receptor tyrosine kinase inhibitors .
22082647	0	tyrosine	144,152	Epidermal_growth_factor_receptor	0,32	tyrosine	Epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY mutations|nmod|inhibitors mutations|nsubj|END_ENTITY	Epidermal_growth_factor_receptor -LRB- EGFR -RRB- mutations in a series of non-small-cell_lung_cancer -LRB- NSCLC -RRB- patients and response rate to EGFR-specific tyrosine kinase inhibitors -LRB- TKIs -RRB- .
22359227	0	tyrosine	124,132	Epidermal_growth_factor_receptor	0,32	tyrosine	Epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|mutations mutations|compound|END_ENTITY	Epidermal_growth_factor_receptor and K-Ras mutations and resistance of lung_cancer to insulin-like_growth_factor_1 receptor tyrosine kinase inhibitors .
22973953	0	tyrosine	33,41	Epidermal_growth_factor_receptor	0,32	tyrosine	Epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Epidermal_growth_factor_receptor tyrosine kinase inhibitors : current status and future perspectives in the development of novel irreversible inhibitors for the treatment of mutant non-small_cell_lung_cancer .
23059777	0	tyrosine	33,41	Epidermal_growth_factor_receptor	0,32	tyrosine	Epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Epidermal_growth_factor_receptor tyrosine kinase inhibitors beyond progressive_disease : a retrospective analysis for Japanese patients with activating EGFR mutations .
23725150	0	tyrosine	33,41	Epidermal_growth_factor_receptor	0,32	tyrosine	Epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitor|compound|START_ENTITY inhibitor|compound|END_ENTITY	Epidermal_growth_factor_receptor tyrosine kinase inhibitor versus placebo as maintenance therapy for advanced non - _ small-cell_lung_cancer : a meta-analysis of randomized controlled trials .
23764002	0	tyrosine	83,91	Epidermal_growth_factor_receptor	0,32	tyrosine	Epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	phosphorylation|amod|START_ENTITY potentiates|nmod|phosphorylation potentiates|nsubj|END_ENTITY	Epidermal_growth_factor_receptor potentiates MCM7-mediated DNA replication through tyrosine phosphorylation of Lyn kinase in human cancers .
23768755	0	tyrosine	33,41	Epidermal_growth_factor_receptor	0,32	tyrosine	Epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY END_ENTITY|dobj|inhibitors	Epidermal_growth_factor_receptor tyrosine kinase inhibitors as initial therapy for non-small_cell_lung_cancer : focus on epidermal_growth_factor_receptor mutation testing and mutation-positive patients .
24715074	0	tyrosine	33,41	Epidermal_growth_factor_receptor	0,32	tyrosine	Epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Epidermal_growth_factor_receptor tyrosine kinase inhibitors vs conventional chemotherapy in non-small_cell_lung_cancer harboring wild-type epidermal_growth_factor_receptor : a meta-analysis .
24770552	0	tyrosine	103,111	Epidermal_growth_factor_receptor	0,32	tyrosine	Epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY skin_toxicity|nmod|inhibitors implications|nmod|skin_toxicity END_ENTITY|dep|implications	Epidermal_growth_factor_receptor signalling in keratinocyte biology : implications for skin_toxicity of tyrosine kinase inhibitors .
25370012	1	tyrosine	168,176	Epidermal_growth_factor_receptor	65,97	tyrosine	Epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY skin_toxicity|nmod|inhibitors implications|nmod|skin_toxicity Commentary|dep|implications Commentary|dep|signalling signalling|compound|END_ENTITY	Commentary to Pastore et al. -LRB- 2014 -RRB- : Epidermal_growth_factor_receptor signalling in keratinocyte biology : implications for skin_toxicity of tyrosine kinase inhibitors .
25922693	0	tyrosine	33,41	Epidermal_growth_factor_receptor	0,32	tyrosine	Epidermal growth factor receptor	D014443	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Epidermal_growth_factor_receptor tyrosine kinase inhibitors in non-small_cell_lung_cancer : a decade of progress and hopeful future .
26781399	0	tyrosine	33,41	Epidermal_growth_factor_receptor	0,32	tyrosine	Epidermal growth factor receptor	D014443	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Epidermal_growth_factor_receptor tyrosine kinase inhibitors in previously treated advanced non-small-cell_lung_cancer with wild-type EGFR .
10648571	0	tyrosine	84,92	ErbB	63,67	tyrosine	ErbB	CHEBI:18186	1956	Chemical	Gene	kinases|amod|START_ENTITY kinases|compound|END_ENTITY	ErbB2 is necessary for induction of carcinoma cell invasion by ErbB family receptor tyrosine kinases .
11566606	0	tyrosine	18,26	ErbB	4,8	tyrosine	ErbB	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|receptor receptor|compound|END_ENTITY	The ErbB receptor tyrosine family as signal integrators .
12006493	0	tyrosine	61,69	ErbB	47,51	tyrosine	ErbB	CHEBI:18186	1956	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Drug-induced ubiquitylation and degradation of ErbB receptor tyrosine kinases : implications for cancer therapy .
12161338	0	tyrosine	14,22	ErbB	0,4	tyrosine	ErbB	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|receptor receptor|compound|END_ENTITY	ErbB receptor tyrosine kinase inhibitors as therapeutic agents .
14508089	0	tyrosine	66,74	ErbB	42,46	tyrosine	ErbB	CHEBI:18186	1956	Chemical	Gene	family|nmod|START_ENTITY family|compound|END_ENTITY	Therapeutic monoclonal antibodies for the ErbB family of receptor tyrosine kinases .
14735165	0	tyrosine	44,52	ErbB	23,27	tyrosine	ErbB	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|receptor receptor|compound|END_ENTITY	Negative regulation of ErbB family receptor tyrosine kinases .
15345710	0	tyrosine	86,94	ErbB	65,69	tyrosine	ErbB	CHEBI:18186	1956	Chemical	Gene	kinases|amod|START_ENTITY kinases|compound|END_ENTITY	The leucine-rich repeat protein LRIG1 is a negative regulator of ErbB family receptor tyrosine kinases .
16751066	0	tyrosine	14,22	ErbB	0,4	tyrosine	ErbB	CHEBI:18186	1956	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|amod|END_ENTITY	ErbB receptor tyrosine kinase network inhibition radiosensitizes carcinoma cells .
17508401	0	tyrosine	46,54	ErbB	25,29	tyrosine	ErbB	CHEBI:18186	1956	Chemical	Gene	kinases|amod|START_ENTITY kinases|compound|END_ENTITY	Mutational activation of ErbB family receptor tyrosine kinases : insights into mechanisms of signal transduction and tumorigenesis .
19084911	0	tyrosine	29,37	ErbB	8,12	tyrosine	ErbB	D014443	1956	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|receptor receptor|compound|END_ENTITY	Role of ErbB family receptor tyrosine kinases in intrahepatic_cholangiocarcinoma .
19318484	0	tyrosine	76,84	ErbB	62,66	tyrosine	ErbB	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|receptor receptor|compound|END_ENTITY	A phase I study with neratinib -LRB- HKI-272 -RRB- , an irreversible pan ErbB receptor tyrosine kinase inhibitor , in patients with solid tumors .
19434003	0	tyrosine	14,22	ErbB	0,4	tyrosine	ErbB	CHEBI:18186	1956	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	ErbB receptor tyrosine kinases contribute to proliferation of malignant_melanoma cells : inhibition by gefitinib -LRB- ZD1839 -RRB- .
20142587	0	tyrosine	41,49	ErbB	27,31	tyrosine	ErbB	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|receptor receptor|compound|END_ENTITY	Neratinib , an irreversible ErbB receptor tyrosine kinase inhibitor , in patients with advanced ErbB2-positive breast_cancer .
21179209	0	tyrosine	61,69	ErbB	56,60	tyrosine	ErbB	CHEBI:18186	1956	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Co-conserved features associated with cis regulation of ErbB tyrosine kinases .
22479596	0	tyrosine	77,85	ErbB	63,67	tyrosine	ErbB	CHEBI:18186	13649(Tax:10090)	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	A knockout of the Tsg101 gene leads to decreased expression of ErbB receptor tyrosine kinases and induction of autophagy prior to cell death .
23333248	0	tyrosine	14,22	ErbB	0,4	tyrosine	ErbB	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|receptor receptor|compound|END_ENTITY	ErbB receptor tyrosine kinase family expression levels in urothelial bladder_carcinoma .
23403595	0	tyrosine	63,71	ErbB	49,53	tyrosine	ErbB	CHEBI:18186	1956	Chemical	Gene	family|compound|START_ENTITY family|compound|END_ENTITY	Apple procyanidins affect several members of the ErbB receptor tyrosine kinase family in vitro .
23416973	0	tyrosine	99,107	ErbB	85,89	tyrosine	ErbB	CHEBI:18186	1956	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Engineering a single ubiquitin ligase for the selective degradation of all activated ErbB receptor tyrosine kinases .
10585492	3	tyrosine	373,381	ErbB-2	499,505	tyrosine	ErbB-2	CHEBI:18186	2064	Chemical	Gene	phosphorylation|amod|START_ENTITY enhanced|dobj|phosphorylation decreased|advcl|enhanced decreased|dobj|phosphorylation phosphorylation|nmod:poss|END_ENTITY	Although EGF enhanced ErbB-2 tyrosine phosphorylation , GH , while causing retardation of its migration on SDS-polyacrylamide gel electrophoresis , decreased ErbB-2 's tyrosine phosphorylation .
10585492	3	tyrosine	508,516	ErbB-2	499,505	tyrosine	ErbB-2	CHEBI:18186	2064	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod:poss|END_ENTITY	Although EGF enhanced ErbB-2 tyrosine phosphorylation , GH , while causing retardation of its migration on SDS-polyacrylamide gel electrophoresis , decreased ErbB-2 's tyrosine phosphorylation .
10938266	0	tyrosine	13,21	ErbB-2	41,47	tyrosine	ErbB-2	CHEBI:18186	2064	Chemical	Gene	START_ENTITY|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Constitutive tyrosine phosphorylation of ErbB-2 via Jak2 by autocrine secretion of prolactin in human breast_cancer .
10986055	0	tyrosine	12,20	ErbB-2	41,47	tyrosine	ErbB-2	CHEBI:18186	2064	Chemical	Gene	phosphorylation|amod|START_ENTITY Activation|appos|phosphorylation Activation|nmod|END_ENTITY	Activation -LRB- tyrosine phosphorylation -RRB- of ErbB-2 -LRB- HER-2 / neu -RRB- : a study of incidence and correlation with outcome in breast_cancer .
11314013	0	tyrosine	9,17	ErbB-2	120,126	tyrosine	ErbB-2	CHEBI:18186	403883(Tax:9615)	Chemical	Gene	START_ENTITY|ccomp|mediate mediate|nmod|receptor receptor|compound|END_ENTITY	Distinct tyrosine autophosphorylation sites mediate induction of epithelial mesenchymal like transition by an activated ErbB-2 / Neu receptor .
11585755	0	tyrosine	49,57	ErbB-2	36,42	tyrosine	ErbB-2	CHEBI:18186	2064	Chemical	Gene	inhibitors|amod|START_ENTITY characterization|dep|inhibitors characterization|nmod|END_ENTITY	The characterization of novel , dual ErbB-2 / EGFR , tyrosine kinase inhibitors : potential therapy for cancer .
11809799	0	tyrosine	46,54	ErbB-2	30,36	tyrosine	ErbB-2	CHEBI:18186	13866(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The catalytic activity of the ErbB-2 receptor tyrosine kinase is essential for embryonic development .
12639547	0	tyrosine	63,71	ErbB-2	51,57	tyrosine	ErbB-2	CHEBI:18186	2064	Chemical	Gene	inhibitors|amod|START_ENTITY Discovery|dep|inhibitors Discovery|nmod|END_ENTITY	Discovery and biological evaluation of potent dual ErbB-2 / EGFR tyrosine kinase inhibitors : 6-thiazolylquinazolines .
15380516	0	tyrosine	64,72	ErbB-2	89,95	tyrosine	ErbB-2	CHEBI:18186	2064	Chemical	Gene	promoter|nmod|START_ENTITY transactivation|nmod|promoter kinase|nsubj|transactivation kinase|dobj|END_ENTITY	Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2 .
16926628	0	tyrosine	113,121	ErbB-2	106,112	tyrosine	ErbB-2	CHEBI:18186	2064	Chemical	Gene	NVP-AEE788|amod|START_ENTITY NVP-AEE788|compound|END_ENTITY	Novel targeted approaches to treating biliary_tract_cancer : the dual epidermal_growth_factor_receptor and ErbB-2 tyrosine kinase inhibitor NVP-AEE788 is more efficient than the epidermal_growth_factor_receptor inhibitors gefitinib and erlotinib .
20498373	0	tyrosine	47,55	ErbB-2	86,92	tyrosine	ErbB-2	CHEBI:18186	2064	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|appos|phosphatase dephosphorylates|nsubj|phosphatase dephosphorylates|dobj|END_ENTITY	Human prostatic acid phosphatase , an authentic tyrosine phosphatase , dephosphorylates ErbB-2 and regulates prostate_cancer cell growth .
9710621	0	tyrosine	94,102	ErbB-2	19,25	tyrosine	ErbB-2	CHEBI:18186	2064	Chemical	Gene	reveals|ccomp|START_ENTITY reveals|nsubj|Activation Activation|nmod|Neu Neu|appos|END_ENTITY	Activation of Neu -LRB- ErbB-2 -RRB- mediated by disulfide bond-induced dimerization reveals a receptor tyrosine kinase dimer interface .
11679632	0	tyrosine	70,78	ErbB-4	54,60	tyrosine	ErbB-4	CHEBI:18186	2066	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	gamma - Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase .
20406946	0	tyrosine	134,142	ErbB1/2	126,133	tyrosine	ErbB1/2	CHEBI:18186	1956;2064	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	X-linked_inhibitor_of_apoptosis_protein inhibits apoptosis in inflammatory_breast_cancer cells with acquired resistance to an ErbB1/2 tyrosine kinase inhibitor .
10648571	0	tyrosine	84,92	ErbB2	0,5	tyrosine	ErbB2	CHEBI:18186	2064	Chemical	Gene	kinases|amod|START_ENTITY necessary|nmod|kinases necessary|nsubj|END_ENTITY	ErbB2 is necessary for induction of carcinoma cell invasion by ErbB family receptor tyrosine kinases .
11467449	0	tyrosine	75,83	ErbB2	60,65	tyrosine	ErbB2	CHEBI:18186	2064	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Myc and mammary cancer : Myc is a downstream effector of the ErbB2 receptor tyrosine kinase .
12034361	0	tyrosine	68,76	ErbB2	0,5	tyrosine	ErbB2	CHEBI:18186	2064	Chemical	Gene	phosphorylation|compound|START_ENTITY quantitatively|dobj|phosphorylation quantitatively|nsubj|END_ENTITY	ErbB2 and ErbB3 do not quantitatively modulate ligand-induced ErbB4 tyrosine phosphorylation .
12386815	2	tyrosine	419,427	ErbB2	474,479	tyrosine	ErbB2	CHEBI:18186	2064	Chemical	Gene	START_ENTITY|advcl|induce induce|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Its transmembrane subunit acts as an intramembrane ligand for the receptor tyrosine kinase ErbB2 to induce the phosphorylation of ErbB2 and , by acting synergistically with the ErbB3 ligand neuregulin , can potentiate the phosphorylation of ErbB2 and ErbB3 .
16091755	0	tyrosine	78,86	ErbB2	72,77	tyrosine	ErbB2	CHEBI:18186	2064	Chemical	Gene	kinases|compound|START_ENTITY kinases|amod|END_ENTITY	Combining lapatinib -LRB- GW572016 -RRB- , a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases , with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast_cancer cells .
16397255	0	tyrosine	60,68	ErbB2	54,59	tyrosine	ErbB2	CHEBI:18186	2064	Chemical	Gene	GW572016|compound|START_ENTITY GW572016|amod|END_ENTITY	Blockade of EGFR and ErbB2 by the novel dual EGFR and ErbB2 tyrosine kinase inhibitor GW572016 sensitizes human colon_carcinoma GEO cells to apoptosis .
16516204	0	tyrosine	112,120	ErbB2	14,19	tyrosine	ErbB2	CHEBI:18186	2064	Chemical	Gene	phosphatases|compound|START_ENTITY role|nmod|phosphatases Activation|dep|role Activation|nmod|END_ENTITY	Activation of ErbB2 by 2-methyl-1 ,4 - naphthoquinone -LRB- menadione -RRB- in human keratinocytes : role of EGFR and protein tyrosine phosphatases .
16682622	0	tyrosine	53,61	ErbB2	47,52	tyrosine	ErbB2	CHEBI:18186	2064	Chemical	Gene	START_ENTITY|nsubj|model model|nmod|autoresistance autoresistance|nmod|END_ENTITY	A model of acquired autoresistance to a potent ErbB2 tyrosine kinase inhibitor and a therapeutic strategy to prevent its onset in breast_cancer .
17060407	0	tyrosine	135,143	ErbB2	129,134	tyrosine	ErbB2	CHEBI:18186	2064	Chemical	Gene	kinases|compound|START_ENTITY kinases|amod|END_ENTITY	Prospective study of positron emission tomography for evaluation of the activity of lapatinib , a dual inhibitor of the ErbB1 and ErbB2 tyrosine kinases , in patients with advanced tumors .
17936675	0	tyrosine	204,212	ErbB2	198,203	tyrosine	ErbB2	CHEBI:18186	2064	Chemical	Gene	kinases|compound|START_ENTITY kinases|amod|END_ENTITY	Chemoprevention of 7,12-dimethylbenz -LSB- a -RSB- anthracene -LRB- DMBA -RRB- - induced oral_carcinogenesis in hamster cheek pouch by topical application of a dual inhibitor of epidermal_growth_factor_receptor -LRB- EGFR -RRB- and ErbB2 tyrosine kinases .
18079969	0	tyrosine	13,21	ErbB2	130,135	tyrosine	ErbB2	CHEBI:18186	13866(Tax:10090)	Chemical	Gene	START_ENTITY|ccomp|promotes promotes|nmod|END_ENTITY	The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma_tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling .
18462377	0	tyrosine	22,30	ErbB2	16,21	tyrosine	ErbB2	CHEBI:18186	2064	Chemical	Gene	START_ENTITY|nsubj|Lack Lack|nmod|END_ENTITY	Lack of somatic ErbB2 tyrosine kinase domain mutations in hepatocellular_carcinoma .
18980964	0	tyrosine	44,52	ErbB2	38,43	tyrosine	ErbB2	CHEBI:18186	2064	Chemical	Gene	START_ENTITY|nsubj|resistance resistance|nmod|END_ENTITY	Acquired resistance to small molecule ErbB2 tyrosine kinase inhibitors .
19331811	0	tyrosine	32,40	ErbB2	14,19	tyrosine	ErbB2	CHEBI:18186	24337(Tax:10116)	Chemical	Gene	inhibitors|compound|START_ENTITY END_ENTITY|nmod|inhibitors	Inhibition of ErbB2 by receptor tyrosine kinase inhibitors causes myofibrillar structural damage without cell death in adult rat cardiomyocytes .
19861407	0	tyrosine	30,38	ErbB2	24,29	tyrosine	ErbB2	CHEBI:18186	2064	Chemical	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Estrogenic promotion of ErbB2 tyrosine kinase activity in mammary_tumor cells requires activation of ErbB3 signaling .
20124457	0	tyrosine	20,28	ErbB2	14,19	tyrosine	ErbB2	CHEBI:18186	2064	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Resistance to ErbB2 tyrosine kinase inhibitors in breast_cancer is mediated by calcium-dependent activation of RelA .
23007710	0	tyrosine	30,38	ErbB2	15,20	tyrosine	ErbB2	CHEBI:18186	2064	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|amod|END_ENTITY	Dual ErbB1 and ErbB2 receptor tyrosine kinase inhibition exerts synergistic effect with conventional chemotherapy in pancreatic_cancer .
24815698	0	tyrosine	101,109	ErbB2	86,91	tyrosine	ErbB2	CHEBI:18186	2064	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Identification of a Src kinase SH3 binding site in the C-terminal domain of the human ErbB2 receptor tyrosine kinase .
25865255	0	tyrosine	14,22	ErbB2	8,13	tyrosine	ErbB2	D014443	24337(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	The rat ErbB2 tyrosine kinase receptor produced in plants is immunogenic in mice and confers protective immunity against ErbB2 -LRB- + -RRB- mammary cancer .
9388271	1	tyrosine	134,142	ErbB2	177,182	tyrosine	ErbB2	CHEBI:18186	24337(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	I. Activation of protein_kinase_C stimulates tyrosine phosphorylation and activation of ErbB2 and ErbB3 .
9637788	0	tyrosine	25,33	ErbB2	88,93	tyrosine	ErbB2	CHEBI:18186	2064	Chemical	Gene	events|amod|START_ENTITY identify|nsubj|events identify|dobj|subsets subsets|amod|END_ENTITY	Adjacent carboxyterminal tyrosine phosphorylation events identify functionally distinct ErbB2 receptor subsets : implications for molecular diagnostics .
9696394	0	tyrosine	15,23	ErbB2	88,93	tyrosine	ErbB2	CHEBI:18186	2064	Chemical	Gene	Shc|amod|START_ENTITY Shc|dep|correlation correlation|nmod|END_ENTITY	Constitutively tyrosine phosphorylated p52 Shc in breast_cancer cells : correlation with ErbB2 and p66 Shc expression .
9855018	0	tyrosine	40,48	ErbB2	34,39	tyrosine	ErbB2	CHEBI:18186	2064	Chemical	Gene	dephosphorylation|compound|START_ENTITY dephosphorylation|amod|END_ENTITY	The duration of phorbol-inducible ErbB2 tyrosine dephosphorylation parallels that of receptor endocytosis rather than threonine-686 phosphorylation : implications for the physiological role of protein_kinase_C in growth factor receptor signalling .
17109639	7	tyrosine	1406,1414	ErbB3	1400,1405	tyrosine	ErbB3	CHEBI:18186	2065	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Results showed that gamma-tocotrienol treatment had little or no effect on ErbB1 or ErbB2 receptor tyrosine phosphorylation , a prerequisite for substrate interaction and signal transduction , but did cause a significant and progressive decrease in the ErbB3 tyrosine phosphorylation .
20661224	0	tyrosine	106,114	ErbB3	91,96	tyrosine	ErbB3	CHEBI:18186	2065	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	ZNF217 , a candidate breast_cancer oncogene amplified at 20q13 , regulates expression of the ErbB3 receptor tyrosine kinase in breast_cancer cells .
21451047	0	tyrosine	36,44	ErbB3	21,26	tyrosine	ErbB3	CHEBI:18186	29496(Tax:10116)	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	A nuclear variant of ErbB3 receptor tyrosine kinase regulates ezrin distribution and Schwann cell myelination .
12034361	0	tyrosine	68,76	ErbB4	62,67	tyrosine	ErbB4	CHEBI:18186	2066	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	ErbB2 and ErbB3 do not quantitatively modulate ligand-induced ErbB4 tyrosine phosphorylation .
14661053	0	tyrosine	111,119	ErbB4	96,101	tyrosine	ErbB4	CHEBI:18186	2066	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Five carboxyl-terminal residues of neuregulin2 are critical for stimulation of signaling by the ErbB4 receptor tyrosine kinase .
17409416	0	tyrosine	115,123	ErbB4	109,114	tyrosine	ErbB4	CHEBI:18186	2066	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	E-cadherin cell-cell adhesion in ewing tumor cells mediates suppression of anoikis through activation of the ErbB4 tyrosine kinase .
25058600	0	tyrosine	18,26	ErbB4	0,5	tyrosine	ErbB4	CHEBI:18186	13869(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY END_ENTITY|appos|kinase	ErbB4 , a receptor tyrosine kinase , coordinates organization of the seminiferous tubules in the developing testis .
25581060	0	tyrosine	100,108	ErbB4	85,90	tyrosine	ErbB4	D014443	13869(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Systemically administered neuregulin-1b1 rescues nigral dopaminergic neurons via the ErbB4 receptor tyrosine kinase in MPTP mouse models of Parkinson 's _ disease .
12214266	0	tyrosine	40,48	Erk1/2	117,123	tyrosine	Erk1/2	CHEBI:18186	5595;5594	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Anti-tumor activity of GW572016 : a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways .
10194437	0	tyrosine	27,35	Erythropoietin	0,14	tyrosine	Erythropoietin	CHEBI:18186	2056	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Erythropoietin induces the tyrosine phosphorylation of GAB1 and its association with SHC , SHP2 , SHIP , and phosphatidylinositol 3-kinase .
1375226	0	tyrosine	27,35	Erythropoietin	0,14	tyrosine	Erythropoietin	CHEBI:18186	2056	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Erythropoietin induces the tyrosine phosphorylation of its own receptor in human erythropoietin-responsive cells .
1377053	0	tyrosine	31,39	Erythropoietin	0,14	tyrosine	Erythropoietin	CHEBI:18186	2056	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Erythropoietin rapidly induces tyrosine phosphorylation in the human erythropoietin-dependent cell line , UT-7 .
7535525	0	tyrosine	23,31	Erythropoietin	0,14	tyrosine	Erythropoietin	CHEBI:18186	2056	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Erythropoietin induces tyrosine phosphorylation of the beta chain of the GM-CSF receptor .
7685196	0	tyrosine	23,31	Erythropoietin	0,14	tyrosine	Erythropoietin	CHEBI:18186	2056	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Erythropoietin induces tyrosine phosphorylation and kinase activity of the c-fps/fes proto-oncogene product in human erythropoietin-responsive cells .
8034732	0	tyrosine	23,31	Erythropoietin	0,14	tyrosine	Erythropoietin	CHEBI:18186	2056	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Erythropoietin induces tyrosine phosphorylation and activation of phospholipase_C-gamma_1 in a human erythropoietin-dependent cell line .
8400282	0	tyrosine	30,38	Erythropoietin	0,14	tyrosine	Erythropoietin	CHEBI:18186	13856(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Erythropoietin stimulates the tyrosine phosphorylation of Shc and its association with Grb2 and a 145-Kd tyrosine phosphorylated protein .
8537396	0	tyrosine	27,35	Erythropoietin	0,14	tyrosine	Erythropoietin	CHEBI:18186	13856(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Erythropoietin induces the tyrosine phosphorylation , nuclear translocation , and DNA binding of STAT1 and STAT5 in erythroid cells .
8742688	0	tyrosine	26,34	Erythropoietin	0,14	tyrosine	Erythropoietin	CHEBI:18186	2056	Chemical	Gene	phosphorylation|amod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Erythropoietin stimulates tyrosine phosphorylation and taurine transport in skate erythrocytes .
9192755	0	tyrosine	23,31	Erythropoietin	0,14	tyrosine	Erythropoietin	CHEBI:18186	13856(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Erythropoietin induces tyrosine phosphorylation of the interleukin-3 receptor beta subunit -LRB- betaIL3 -RRB- and recruitment of Stat5 to possible Stat5-docking sites in betaIL3 .
9334184	0	tyrosine	27,35	Erythropoietin	0,14	tyrosine	Erythropoietin	CHEBI:18186	2056	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Erythropoietin induces the tyrosine phosphorylation of insulin_receptor_substrate-2 .
9344843	0	tyrosine	31,39	Erythropoietin	0,14	tyrosine	Erythropoietin	CHEBI:18186	13856(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY induce|dobj|phosphorylation induce|nsubj|END_ENTITY	Erythropoietin and IL-3 induce tyrosine phosphorylation of CrkL and its association with Shc , SHP-2 , and Cbl in hematopoietic cells .
9657743	0	tyrosine	23,31	Erythropoietin	0,14	tyrosine	Erythropoietin	CHEBI:18186	2056	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Erythropoietin induces tyrosine phosphorylation of Jak2 , STAT5A , and STAT5B in primary cultured human erythroid precursors .
24590645	0	tyrosine	31,39	Estrogen_receptor	0,17	tyrosine	Estrogen receptor	CHEBI:18186	2099	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Estrogen_receptor and receptor tyrosine kinase signaling : use of combinatorial hormone and epidermal growth factor receptor/human epidermal growth factor receptor 2-targeted therapies for breast_cancer .
10688651	0	tyrosine	18,26	Etk	0,3	tyrosine	Etk	CHEBI:18186	12169(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY END_ENTITY|appos|kinase	Etk , a Btk family tyrosine kinase , mediates cellular transformation by linking Src to STAT3 activation .
11331870	0	tyrosine	39,47	Etk	55,58	tyrosine	Etk	CHEBI:18186	12169(Tax:10090)	Chemical	Gene	Regulation|nmod|START_ENTITY kinase|nsubj|Regulation kinase|dobj|END_ENTITY	Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain .
11877430	0	tyrosine	20,28	Etk	36,39	tyrosine	Etk	CHEBI:18186	12169(Tax:10090)	Chemical	Gene	Interaction|nmod|START_ENTITY kinase|nsubj|Interaction kinase|dobj|END_ENTITY	Interaction between tyrosine kinase Etk and a RUN domain - and FYVE domain-containing protein RUFY1 .
10580994	0	tyrosine	30,38	FAK	58,61	tyrosine	FAK	CHEBI:18186	5747	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Why do so many stimuli induce tyrosine phosphorylation of FAK ?
11110790	3	tyrosine	528,536	FAK	524,527	tyrosine	FAK	CHEBI:18186	5747	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Antibodies to the alpha -LRB- 2 -RRB- and beta -LRB- 1 -RRB- _ integrin subunits did not inhibit platelet FAK tyrosine phosphorylation caused by either collagen fibers or CRP-XL .
11604500	0	tyrosine	35,43	FAK	63,66	tyrosine	FAK	CHEBI:18186	5747	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Mechanisms of CAS substrate domain tyrosine phosphorylation by FAK and Src .
11606050	0	tyrosine	60,68	FAK	55,58	tyrosine	FAK	CHEBI:18186	14083(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	Uniaxial cyclic stretch induces focal_adhesion_kinase -LRB- FAK -RRB- tyrosine phosphorylation followed by mitogen-activated protein kinase -LRB- MAPK -RRB- activation .
11787067	0	tyrosine	14,22	FAK	0,3	tyrosine	FAK	CHEBI:18186	14083(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY regulates|dobj|phosphorylation regulates|nsubj|END_ENTITY	FAK regulates tyrosine phosphorylation of CAS , paxillin , and PYK2 in cells expressing v-Src , but is not a critical determinant of v-Src transformation .
12190987	0	tyrosine	54,62	FAK	82,85	tyrosine	FAK	CHEBI:18186	14083(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	PKC-regulated myogenesis is associated with increased tyrosine phosphorylation of FAK , Cas , and paxillin , formation of Cas-CRK complex , and JNK activation .
12796479	0	tyrosine	99,107	FAK	95,98	tyrosine	FAK	CHEBI:18186	14083(Tax:10090)	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|compound|END_ENTITY	Reactive oxygen species as essential mediators of cell adhesion : the oxidative inhibition of a FAK tyrosine phosphatase is required for cell adhesion .
15172101	0	tyrosine	40,48	FAK	27,30	tyrosine	FAK	CHEBI:18186	25614(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|END_ENTITY	Differential regulation of FAK and PYK2 tyrosine phosphorylation after electroconvulsive shock in the rat brain .
15221336	0	tyrosine	14,22	FAK	31,34	tyrosine	FAK	CHEBI:18186	5747	Chemical	Gene	Expression|nmod|START_ENTITY kinases|nsubj|Expression kinases|dobj|END_ENTITY	Expression of tyrosine kinases FAK and Pyk2 in 331 human astrocytomas .
16052481	0	tyrosine	19,27	FAK	47,50	tyrosine	FAK	CHEBI:18186	5747	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Garcinol modulates tyrosine phosphorylation of FAK and subsequently induces apoptosis through down-regulation of Src , ERK , and Akt survival signaling in human colon_cancer cells .
18613116	0	tyrosine	71,79	FAK	101,104	tyrosine	FAK	CHEBI:18186	5747	Chemical	Gene	dephosphorylation|amod|START_ENTITY dephosphorylation|nmod|END_ENTITY	CaMK-II promotes focal adhesion turnover and cell motility by inducing tyrosine dephosphorylation of FAK and paxillin .
8647278	0	tyrosine	75,83	FAK	71,74	tyrosine	FAK	CHEBI:18186	25614(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Protein kinase C and F-actin are essential for stimulation of neuronal FAK tyrosine phosphorylation by G-proteins and amyloid beta protein .
9257837	0	tyrosine	35,43	FAK	63,66	tyrosine	FAK	CHEBI:18186	5747	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	T cell receptor engagement induces tyrosine phosphorylation of FAK and Pyk2 and their association with Lck .
20423996	7	tyrosine	1309,1317	FASN	1293,1297	tyrosine	FASN	CHEBI:18186	2194	Chemical	Gene	kinase|compound|START_ENTITY END_ENTITY|nmod|kinase	These findings provide evidence that FASN , via c-Met tyrosine kinase , plays a critical role in the carcinogenesis of DLBCL and strongly suggest that targeting FASN may have therapeutic value in treatment of DLBCL .
1678513	0	tyrosine	10,18	FER	32,35	tyrosine	FER	CHEBI:18186	2241	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The human tyrosine kinase gene -LRB- FER -RRB- detects an RFLP with BgII .
21518868	0	tyrosine	4,12	FER	21,24	tyrosine	FER	CHEBI:18186	2241	Chemical	Gene	START_ENTITY|ccomp|mediates mediates|nsubj|overexpression overexpression|appos|END_ENTITY	FER tyrosine kinase -LRB- FER -RRB- overexpression mediates resistance to quinacrine through EGF-dependent activation of NF-kappaB .
2209086	0	tyrosine	10,18	FER	32,35	tyrosine	FER	CHEBI:18186	2241	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The human tyrosine kinase gene -LRB- FER -RRB- maps to chromosome 5 and is deleted in myeloid_leukemias with a del -LRB- 5q -RRB- .
23420638	0	tyrosine	23,31	FER	19,22	tyrosine	FER	CHEBI:18186	2241	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	High expression of FER tyrosine kinase predicts poor prognosis in clear_cell_renal_cell_carcinoma .
7623846	0	tyrosine	16,24	FER	32,35	tyrosine	FER	CHEBI:18186	2241	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|ccomp|associated associated|nsubjpass|END_ENTITY	The cytoplasmic tyrosine kinase FER is associated with the catenin-like substrate pp120 and is activated by growth factors .
15344379	0	tyrosine	94,102	FGFR1	88,93	tyrosine	FGFR1	CHEBI:18186	14182(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The intracellular microenvironment in host cell-specific phosphorylation of SNT1 by the FGFR1 tyrosine kinase .
17901128	0	tyrosine	44,52	FGFR1	37,42	tyrosine	FGFR1	CHEBI:18186	2260	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	Fibroblast_growth_factor_receptor_1 -LRB- FGFR1 -RRB- tyrosine phosphorylation regulates binding of FGFR_substrate_2alpha -LRB- FRS2alpha -RRB- but not FRS2 to the receptor .
21543745	0	tyrosine	45,53	FGFR1	39,44	tyrosine	FGFR1	CHEBI:18186	79114(Tax:10116)	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	NP603 , a novel and potent inhibitor of FGFR1 tyrosine kinase , inhibits hepatic stellate cell proliferation and ameliorates hepatic_fibrosis in rats .
26300540	0	tyrosine	85,93	FGFR1	105,110	tyrosine	FGFR1	D014443	2260	Chemical	Gene	residue|amod|START_ENTITY residue|nmod|END_ENTITY	Structural analysis of the mechanism of phosphorylation of a critical autoregulatory tyrosine residue in FGFR1 kinase domain .
15523615	0	tyrosine	22,30	FGFR2	48,53	tyrosine	FGFR2	CHEBI:18186	2263	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Novel mutation in the tyrosine kinase domain of FGFR2 in a patient with Pfeiffer_syndrome .
16441300	0	tyrosine	28,36	FGFR3	63,68	tyrosine	FGFR3	CHEBI:18186	554324(Tax:9940)	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	A single-base change in the tyrosine kinase II domain of ovine FGFR3 causes hereditary_chondrodysplasia in sheep .
8752212	0	tyrosine	30,38	FGF_receptor	17,29	tyrosine	FGF receptor	CHEBI:18186	2263	Chemical	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	Structure of the FGF_receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism .
7519620	0	tyrosine	93,101	FGR	81,84	tyrosine	FGR	CHEBI:18186	2268	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Beta_2 integrin-dependent protein tyrosine phosphorylation and activation of the FGR protein tyrosine kinase in human neutrophils .
11278468	0	tyrosine	18,26	FLK-1	85,90	tyrosine	FLK-1	CHEBI:18186	3791	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Identification of tyrosine residues in vascular_endothelial_growth_factor_receptor-2 / FLK-1 involved in activation of phosphatidylinositol_3-kinase and cell proliferation .
8672130	0	tyrosine	100,108	FLT	117,120	tyrosine	FLT	CHEBI:18186	2321	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	Syntenic assignment of human serotonin receptor subtype 2 -LRB- HTR2 -RRB- , esterase_D -LRB- ESD -RRB- , and fms-related tyrosine kinase -LRB- FLT -RRB- homologs to bovine chromosome 12 .
10329444	0	tyrosine	153,161	FLT-1	186,191	tyrosine	FLT-1	CHEBI:18186	2321	Chemical	Gene	family|compound|START_ENTITY activation|nmod|family stellate|nmod|activation stellate|xcomp|END_ENTITY	Inhibition of hepatic stellate cell contraction during activation in vitro by vascular_endothelial_growth_factor in association with upregulation of FLT tyrosine kinase receptor family , FLT-1 .
19754810	0	tyrosine	23,31	FLT-1	49,54	tyrosine	FLT-1	CHEBI:18186	2321	Chemical	Gene	Expression|nmod|START_ENTITY kinases|nsubj|Expression kinases|dobj|VEGFR-1 VEGFR-1|appos|END_ENTITY	Expression of receptor tyrosine kinases VEGFR-1 -LRB- FLT-1 -RRB- , VEGFR-2 -LRB- KDR -RRB- , EGFR-1 , PDGFRalpha and c-Met in canine primary brain_tumours .
11468194	0	tyrosine	7,15	FLT3	101,105	tyrosine	FLT3	CHEBI:18186	2322	Chemical	Gene	inhibitor|compound|START_ENTITY cytotoxic|nsubj|inhibitor cytotoxic|xcomp|harboring harboring|dobj|mutations mutations|nummod|END_ENTITY	A FLT3 tyrosine kinase inhibitor is selectively cytotoxic to acute_myeloid_leukemia blasts harboring FLT3 internal tandem duplication mutations .
11468194	0	tyrosine	7,15	FLT3	2,6	tyrosine	FLT3	CHEBI:18186	2322	Chemical	Gene	inhibitor|compound|START_ENTITY inhibitor|compound|END_ENTITY	A FLT3 tyrosine kinase inhibitor is selectively cytotoxic to acute_myeloid_leukemia blasts harboring FLT3 internal tandem duplication mutations .
11640895	0	tyrosine	9,17	FLT3	4,8	tyrosine	FLT3	CHEBI:18186	2322	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	The FLT3 tyrosine kinase receptor inhibits neural stem/progenitor cell proliferation and collaborates with NGF to promote neuronal survival .
12124173	0	tyrosine	76,84	FLT3	21,25	tyrosine	FLT3	CHEBI:18186	14255(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|receptors receptors|compound|END_ENTITY	Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412 .
12357354	0	tyrosine	107,115	FLT3	43,47	tyrosine	FLT3	CHEBI:18186	2322	Chemical	Gene	inhibitor|amod|START_ENTITY mutants|nmod|inhibitor mutants|nsubj|Inhibition Inhibition|nmod|activity activity|nmod|duplication duplication|compound|END_ENTITY	Inhibition of the transforming activity of FLT3 internal tandem duplication mutants from AML patients by a tyrosine kinase inhibitor .
12531805	0	tyrosine	24,32	FLT3	19,23	tyrosine	FLT3	CHEBI:18186	2322	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo .
12580961	0	tyrosine	42,50	FLT3	74,78	tyrosine	FLT3	CHEBI:18186	2322	Chemical	Gene	kinases|compound|START_ENTITY analysis|nmod|kinases analysis|appos|C-KIT C-KIT|dep|END_ENTITY	Mutational analysis of class III receptor tyrosine kinases -LRB- C-KIT , C-FMS , FLT3 -RRB- in idiopathic_myelofibrosis .
12663439	0	tyrosine	19,27	FLT3	99,103	tyrosine	FLT3	CHEBI:18186	2322	Chemical	Gene	inhibitors|amod|START_ENTITY Sensitivity|nmod|inhibitors varies|nsubj|Sensitivity varies|nmod|mutations mutations|nmod|receptor receptor|compound|END_ENTITY	Sensitivity toward tyrosine kinase inhibitors varies between different activating mutations of the FLT3 receptor .
12815052	0	tyrosine	52,60	FLT3	159,163	tyrosine	FLT3	CHEBI:18186	2322	Chemical	Gene	START_ENTITY|nmod|cells cells|acl|expressing expressing|dobj|Fms-like_tyrosine_kinase_3 Fms-like_tyrosine_kinase_3|appos|END_ENTITY	Selective cytotoxic mechanism of GTP-14564 , a novel tyrosine kinase inhibitor in leukemia cells expressing a constitutively active Fms-like_tyrosine_kinase_3 -LRB- FLT3 -RRB- .
14504097	0	tyrosine	41,49	FLT3	0,4	tyrosine	FLT3	CHEBI:18186	2322	Chemical	Gene	domain|amod|START_ENTITY loop|nmod|domain mutations|nmod|loop mutations|nummod|END_ENTITY	FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant_ALL with MLL rearrangements and pediatric_ALL with hyperdiploidy .
14604974	0	tyrosine	17,25	FLT3	43,47	tyrosine	FLT3	CHEBI:18186	2322	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Mutations in the tyrosine kinase domain of FLT3 define a new molecular mechanism of acquired drug resistance to PTK inhibitors in FLT3-ITD-transformed hematopoietic cells .
15158089	0	tyrosine	36,44	FLT3	75,79	tyrosine	FLT3	CHEBI:18186	2322	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effects of SU5416 , a small molecule tyrosine kinase receptor inhibitor , on FLT3 expression and phosphorylation in patients with refractory acute_myeloid_leukemia .
15256420	0	tyrosine	77,85	FLT3	24,28	tyrosine	FLT3	CHEBI:18186	14255(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|sensitivity sensitivity|nmod|mutations mutations|nummod|END_ENTITY	Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518 .
15345597	0	tyrosine	105,113	FLT3	100,104	tyrosine	FLT3	CHEBI:18186	2322	Chemical	Gene	inhibitor|compound|START_ENTITY inhibitor|compound|END_ENTITY	Patients with acute_myeloid_leukemia and an activating mutation in FLT3 respond to a small-molecule FLT3 tyrosine kinase inhibitor , PKC412 .
15815726	0	tyrosine	96,104	FLT3	82,86	tyrosine	FLT3	CHEBI:18186	2322	Chemical	Gene	START_ENTITY|nsubj|Identification Identification|nmod|Ki23819 Ki23819|appos|inhibitor inhibitor|nmod|activity activity|nmod|receptor receptor|compound|END_ENTITY	Identification of Ki23819 , a highly potent inhibitor of kinase activity of mutant FLT3 receptor tyrosine kinase .
16091740	0	tyrosine	9,17	FLT3	81,85	tyrosine	FLT3	CHEBI:18186	14255(Tax:10090)	Chemical	Gene	Roles|nmod|START_ENTITY residues|nsubj|Roles residues|nmod|activation activation|nmod|mutant mutant|compound|END_ENTITY	Roles of tyrosine residues 845 , 892 and 922 in constitutive activation of murine FLT3 kinase domain mutant .
16150941	0	tyrosine	112,120	FLT3	107,111	tyrosine	FLT3	CHEBI:18186	2322	Chemical	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	Clinical resistance to the kinase inhibitor PKC412 in acute_myeloid_leukemia by mutation of Asn-676 in the FLT3 tyrosine kinase domain .
16185475	0	tyrosine	39,47	FLT3	65,69	tyrosine	FLT3	CHEBI:18186	2322	Chemical	Gene	mutation|nmod|START_ENTITY Detection|nmod|mutation kinase|nsubj|Detection kinase|dobj|domain domain|nmod|gene gene|nummod|END_ENTITY	-LSB- Detection of point mutation at second tyrosine kinase domain of FLT3 gene in acute_myeloid_leukemia -RSB- .
16956345	0	tyrosine	52,60	FLT3	47,51	tyrosine	FLT3	CHEBI:18186	2322	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	G __ 6976 is a potent inhibitor of the JAK_2 and FLT3 tyrosine kinases with significant activity in primary acute_myeloid_leukaemia cells .
17209055	0	tyrosine	34,42	FLT3	75,79	tyrosine	FLT3	CHEBI:18186	2322	Chemical	Gene	inhibitor|compound|START_ENTITY ABT-869|appos|inhibitor ABT-869|dep|inhibition inhibition|nmod|END_ENTITY	ABT-869 , a multitargeted receptor tyrosine kinase inhibitor : inhibition of FLT3 phosphorylation and signaling in acute_myeloid_leukemia .
17210255	0	tyrosine	29,37	FLT3	14,18	tyrosine	FLT3	CHEBI:18186	2322	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of FLT3 and PDGFR tyrosine kinase activity by bis -LRB- benzo -LSB- b -RSB- furan-2-yl -RRB- methanones .
17456725	0	tyrosine	5,13	FLT3	0,4	tyrosine	FLT3	CHEBI:18186	2322	Chemical	Gene	kinase|amod|START_ENTITY mutations|amod|kinase mutations|nummod|END_ENTITY	FLT3 tyrosine kinase domain mutations are biologically distinct from and have a significantly more favorable prognosis than FLT3 internal tandem duplications in patients with acute_myeloid_leukemia .
17827387	0	tyrosine	59,67	FLT3	23,27	tyrosine	FLT3	CHEBI:18186	14255(Tax:10090)	Chemical	Gene	midostaurin|amod|START_ENTITY mutants|nmod|midostaurin mutants|nsubj|sensitivity sensitivity|nmod|loop loop|compound|END_ENTITY	Uniform sensitivity of FLT3 activation loop mutants to the tyrosine kinase inhibitor midostaurin .
17851558	0	tyrosine	28,36	FLT3	0,4	tyrosine	FLT3	D014443	2322	Chemical	Gene	phosphorylation|compound|START_ENTITY regulates|dobj|phosphorylation regulates|nsubj|END_ENTITY	FLT3 regulates beta-catenin tyrosine phosphorylation , nuclear localization , and transcriptional activity in acute_myeloid_leukemia cells .
18341639	0	tyrosine	43,51	FLT3	136,140	tyrosine	FLT3	CHEBI:18186	2322	Chemical	Gene	mutation|amod|START_ENTITY cells|nmod|mutation sensitive|nsubj|cells sensitive|xcomp|lestaurtinib lestaurtinib|nmod|those those|nmod|duplication duplication|compound|END_ENTITY	Acute_myeloid_leukaemia blast cells with a tyrosine kinase domain mutation of FLT3 are less sensitive to lestaurtinib than those with a FLT3 internal tandem duplication .
18341639	0	tyrosine	43,51	FLT3	78,82	tyrosine	FLT3	CHEBI:18186	2322	Chemical	Gene	mutation|amod|START_ENTITY mutation|nmod|END_ENTITY	Acute_myeloid_leukaemia blast cells with a tyrosine kinase domain mutation of FLT3 are less sensitive to lestaurtinib than those with a FLT3 internal tandem duplication .
18341639	1	tyrosine	175,183	FLT3	170,174	tyrosine	FLT3	CHEBI:18186	2322	Chemical	Gene	mutations|amod|START_ENTITY mutations|nummod|END_ENTITY	FLT3 tyrosine kinase domain mutations -LRB- FLT3/TKDs -RRB- are associated with a favourable prognosis in acute_myeloid_leukaemia -LRB- AML -RRB- , unlike FLT3 internal tandem duplications -LRB- FLT3/ITDs -RRB- that have a poor prognosis .
18483393	0	tyrosine	96,104	FLT3	91,95	tyrosine	FLT3	CHEBI:18186	14255(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Identification of a novel type of ITD mutations located in nonjuxtamembrane domains of the FLT3 tyrosine kinase receptor .
19064725	0	tyrosine	48,56	FLT3	176,180	tyrosine	FLT3	CHEBI:18186	2322	Chemical	Gene	apoptosis|amod|START_ENTITY Puma|nmod|apoptosis critical|nmod|Puma Bim|amod|critical progenitors|nsubj|Bim progenitors|xcomp|carrying carrying|dobj|END_ENTITY	BH3-only protein Bim more critical than Puma in tyrosine kinase inhibitor-induced apoptosis of human leukemic cells and transduced hematopoietic progenitors carrying oncogenic FLT3 .
19602710	0	tyrosine	53,61	FLT3	13,17	tyrosine	FLT3	CHEBI:18186	2322	Chemical	Gene	domain-1|amod|START_ENTITY duplication|nmod|domain-1 duplication|nummod|END_ENTITY	Insertion of FLT3 internal tandem duplication in the tyrosine kinase domain-1 is associated with resistance to chemotherapy and inferior outcome .
20435347	0	tyrosine	98,106	FLT3	0,4	tyrosine	FLT3	CHEBI:18186	2322	Chemical	Gene	SU11657|amod|START_ENTITY vitro|nmod|SU11657 sensitive|advcl|vitro sensitive|nsubj|samples samples|compound|acute_myeloid_leukemia acute_myeloid_leukemia|compound|END_ENTITY	FLT3 and KIT mutated pediatric acute_myeloid_leukemia -LRB- AML -RRB- samples are sensitive in vitro to the tyrosine kinase inhibitor SU11657 .
21262971	0	tyrosine	53,61	FLT3	69,73	tyrosine	FLT3	CHEBI:18186	2322	Chemical	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling .
21338238	0	tyrosine	9,17	FLT3	26,30	tyrosine	FLT3	CHEBI:18186	2322	Chemical	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	Fms like tyrosine kinase -LRB- FLT3 -RRB- and nucleophosmin_1 -LRB- NPM1 -RRB- mutations in de novo normal karyotype acute_myeloid_leukemia -LRB- AML -RRB- .
21546568	0	tyrosine	100,108	FLT3	95,99	tyrosine	FLT3	CHEBI:18186	2322	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Stromal niche cells protect early leukemic FLT3-ITD + progenitor cells against first-generation FLT3 tyrosine kinase inhibitors .
22733614	0	tyrosine	89,97	FLT3	0,4	tyrosine	FLT3	CHEBI:18186	2322	Chemical	Gene	domain|amod|START_ENTITY mutations|nmod|domain mutations|nsubj|END_ENTITY	FLT3 and NPM1 mutations in a cohort of AML patients and detection of a novel mutation in tyrosine kinase domain of FLT3 gene from Western India .
22733614	0	tyrosine	89,97	FLT3	115,119	tyrosine	FLT3	CHEBI:18186	2322	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|gene gene|compound|END_ENTITY	FLT3 and NPM1 mutations in a cohort of AML patients and detection of a novel mutation in tyrosine kinase domain of FLT3 gene from Western India .
23216927	0	tyrosine	17,25	FLT3	45,49	tyrosine	FLT3	CHEBI:18186	2322	Chemical	Gene	START_ENTITY|dobj|activity activity|nmod|END_ENTITY	SU11652 Inhibits tyrosine kinase activity of FLT3 and growth of MV-4-11 cells .
23321254	0	tyrosine	27,35	FLT3	73,77	tyrosine	FLT3	CHEBI:18186	2322	Chemical	Gene	Inhibition|nmod|START_ENTITY kinase|nsubj|Inhibition kinase|ccomp|impedes impedes|dobj|activation activation|nmod|duplication duplication|compound|END_ENTITY	Inhibition of the receptor tyrosine kinase Axl impedes activation of the FLT3 internal tandem duplication in human acute_myeloid_leukemia : implications for Axl as a potential therapeutic target .
23631653	0	tyrosine	5,13	FLT3	0,4	tyrosine	FLT3	CHEBI:18186	2322	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nummod|END_ENTITY	FLT3 tyrosine kinase inhibitors in acute_myeloid_leukemia : clinical implications and limitations .
23707526	0	tyrosine	4,12	FLT3	40,44	tyrosine	FLT3	CHEBI:18186	2322	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|nmod|receptors receptors|compound|END_ENTITY	The tyrosine kinase CSK associates with FLT3 and c-Kit receptors and regulates downstream signaling .
23969938	0	tyrosine	29,37	FLT3	24,28	tyrosine	FLT3	CHEBI:18186	2322	Chemical	Gene	START_ENTITY|nsubj|Emergence Emergence|nmod|END_ENTITY	Emergence of polyclonal FLT3 tyrosine kinase domain mutations during sequential therapy with sorafenib and sunitinib in FLT3-ITD-positive acute_myeloid_leukemia .
24408321	0	tyrosine	25,33	FLT3	20,24	tyrosine	FLT3	CHEBI:18186	2322	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	TTT-3002 is a novel FLT3 tyrosine kinase inhibitor with activity against FLT3-associated leukemias in vitro and in vivo .
25216797	0	tyrosine	14,22	FLT3	31,35	tyrosine	FLT3	CHEBI:18186	2322	Chemical	Gene	START_ENTITY|ccomp|predicts predicts|nsubj|transcript transcript|appos|END_ENTITY	High receptor tyrosine kinase -LRB- FLT3 , KIT -RRB- transcript versus anti-apoptotic -LRB- BCL2 -RRB- transcript ratio independently predicts inferior outcome in pediatric acute_myeloid_leukemia .
26870340	0	tyrosine	32,40	FLT3	68,72	tyrosine	FLT3	D014443	14255(Tax:10090)	Chemical	Gene	mutations|amod|START_ENTITY mutations|nmod|END_ENTITY	Internal tandem duplication and tyrosine kinase domain mutations in FLT3 alter the response to daunorubicin in Ba/F3 cells .
7914866	0	tyrosine	126,134	FLT3	107,111	tyrosine	FLT3	CHEBI:18186	2322	Chemical	Gene	genes|amod|START_ENTITY genes|nummod|END_ENTITY	Characterization of a yeast artificial chromosome from human chromosome band 13q12 containing the FLT1 and FLT3 receptor-type tyrosine kinase genes .
8056344	0	tyrosine	130,138	FLT3	54,58	tyrosine	FLT3	CHEBI:18186	2322	Chemical	Gene	kinases|compound|START_ENTITY encoding|dobj|kinases genes|acl|encoding conservation|nmod|genes structure|dep|conservation structure|nmod|part part|nmod|gene gene|compound|END_ENTITY	Genomic structure of the downstream part of the human FLT3 gene : exon/intron structure conservation among genes encoding receptor tyrosine kinases -LRB- RTK -RRB- of subclass III .
8677746	0	tyrosine	47,55	FLT3	42,46	tyrosine	FLT3	CHEBI:18186	2322	Chemical	Gene	START_ENTITY|nsubj|transduction transduction|nmod|END_ENTITY	Expression and signal transduction of the FLT3 tyrosine kinase receptor .
8847893	0	tyrosine	32,40	FLT3	49,53	tyrosine	FLT3	CHEBI:18186	2322	Chemical	Gene	Expression|nmod|START_ENTITY kinases|nsubj|Expression kinases|dobj|END_ENTITY	Expression of type III receptor tyrosine kinases FLT3 and KIT and responses to their ligands by acute_myeloid_leukemia blasts .
9207445	0	tyrosine	114,122	FLT3	92,96	tyrosine	FLT3	CHEBI:18186	2322	Chemical	Gene	kinase|amod|START_ENTITY receptor|amod|kinase receptor|amod|END_ENTITY	Functional and phenotypic characterization of cord blood and bone marrow subsets expressing FLT3 -LRB- CD135 -RRB- receptor tyrosine kinase .
1310071	3	tyrosine	386,394	FLT4	381,385	tyrosine	FLT1	CHEBI:18186	2321	Chemical	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	The FLT4 tyrosine kinase domain is 79 % homologous with the previously cloned FLT1 -LRB- M. Shibuya et al. , Oncogene , 5 : 519-524 , 1990 -RRB- tyrosine kinase and maps to the chromosomal region 5q33-qter .
1310071	3	tyrosine	507,515	FLT4	381,385	tyrosine	FLT1	CHEBI:18186	2321	Chemical	Gene	kinase|amod|START_ENTITY homologous|nmod|kinase homologous|nsubj|domain domain|compound|END_ENTITY	The FLT4 tyrosine kinase domain is 79 % homologous with the previously cloned FLT1 -LRB- M. Shibuya et al. , Oncogene , 5 : 519-524 , 1990 -RRB- tyrosine kinase and maps to the chromosomal region 5q33-qter .
1327515	0	tyrosine	14,22	FLT4	0,4	tyrosine	FLT4	CHEBI:18186	2324	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines .
7675451	0	tyrosine	12,20	FLT4	90,94	tyrosine	FLT4	CHEBI:18186	2324	Chemical	Gene	residue|compound|START_ENTITY Mutation|nmod|residue abrogates|nsubj|Mutation abrogates|dobj|capacity capacity|nmod|receptor receptor|compound|END_ENTITY	Mutation at tyrosine residue 1337 abrogates ligand-dependent transforming capacity of the FLT4 receptor .
7687867	0	tyrosine	14,22	FLT4	0,4	tyrosine	FLT4	CHEBI:18186	2324	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	FLT4 receptor tyrosine kinase gene mapping to chromosome band 5q35 in relation to the t -LRB- 2 ; 5 -RRB- , t -LRB- 5 ; 6 -RRB- , and t -LRB- 3 ; 5 -RRB- translocations .
7692369	0	tyrosine	24,32	FLT4	10,14	tyrosine	FLT4	CHEBI:18186	2324	Chemical	Gene	isoforms|compound|START_ENTITY isoforms|compound|END_ENTITY	Two human FLT4 receptor tyrosine kinase isoforms with distinct carboxy terminal tails are produced by alternative processing of primary transcripts .
7970715	0	tyrosine	68,76	FLT4	25,29	tyrosine	FLT4	CHEBI:18186	14257(Tax:10090)	Chemical	Gene	kinase|amod|START_ENTITY receptor|amod|kinase related|nsubj|receptor related|advcl|Signalling Signalling|dobj|properties properties|nmod|END_ENTITY	Signalling properties of FLT4 , a proteolytically processed receptor tyrosine kinase related to two VEGF receptors .
8386825	0	tyrosine	38,46	FLT4	4,8	tyrosine	FLT4	CHEBI:18186	2324	Chemical	Gene	kinase|compound|START_ENTITY encodes|dobj|kinase encodes|nsubj|gene gene|compound|END_ENTITY	The FLT4 gene encodes a transmembrane tyrosine kinase related to the vascular endothelial growth factor receptor .
19059247	0	tyrosine	108,116	FMIP	145,149	tyrosine	FMIP	CHEBI:18186	8563	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Nuclear localization of the pre-mRNA associating protein THOC7 depends upon its direct interaction with Fms tyrosine kinase interacting protein -LRB- FMIP -RRB- .
27044711	0	tyrosine	41,49	FOXO1	11,16	tyrosine	FOXO1	D014443	2308	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	A role for FOXO1 in BCR-ABL1-independent tyrosine kinase inhibitor resistance in chronic_myeloid_leukemia .
15611931	0	tyrosine	29,37	FRK	51,54	tyrosine	FRK	CHEBI:18186	2444	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of a SRC-like tyrosine kinase gene , FRK , fused with ETV6 in a patient with acute_myelogenous_leukemia carrying a t -LRB- 6 ; 12 -RRB- -LRB- q21 ; p13 -RRB- translocation .
19652529	0	tyrosine	65,73	FRK	81,84	tyrosine	FRK	CHEBI:18186	2444	Chemical	Gene	function|nmod|START_ENTITY kinase|nsubj|function kinase|dobj|END_ENTITY	RAKing in AKT : a tumor suppressor function for the intracellular tyrosine kinase FRK .
19793767	0	tyrosine	13,21	FRNK	8,12	tyrosine	FRNK	CHEBI:18186	25614(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of FRNK tyrosine phosphorylation in vascular smooth muscle spreading and migration .
10748122	0	tyrosine	108,116	FRS2	136,140	tyrosine	FRS2	CHEBI:18186	10818	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	A novel type I fibroblast growth factor receptor activates mitogenic signaling in the absence of detectable tyrosine phosphorylation of FRS2 .
9632781	0	tyrosine	16,24	FRS2	40,44	tyrosine	FRS2	CHEBI:18186	314850(Tax:10116)	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|nmod|END_ENTITY	Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation .
17703099	0	tyrosine	24,32	FYN	40,43	tyrosine	FYN	CHEBI:18186	2534	Chemical	Gene	kinase|amod|START_ENTITY analysis|nmod|kinase END_ENTITY|nsubj|analysis	Association analysis of tyrosine kinase FYN gene polymorphisms in asthmatic children .
11420674	0	tyrosine	33,41	Fak	61,64	tyrosine	Fak	CHEBI:18186	14083(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Different modes and qualities of tyrosine phosphorylation of Fak and Pyk2 during epithelial-mesenchymal transdifferentiation and cell migration : analysis of specific phosphorylation events using site-directed antibodies .
7561053	0	tyrosine	66,74	Fc_epsilon_RI	99,112	tyrosine	Fc epsilon RI	CHEBI:18186	2205	Chemical	Gene	kinase|compound|START_ENTITY kinase|nmod|END_ENTITY	Activation and interaction with protein_kinase_C of a cytoplasmic tyrosine kinase , Itk/Tsk/Emt , on Fc_epsilon_RI cross-linking on mast cells .
9531278	0	tyrosine	103,111	Fc_epsilon_RI	131,144	tyrosine	Fc epsilon RI	CHEBI:18186	2205	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Kinetics of multivalent antigen DNP-BSA binding to IgE-Fc_epsilon_RI in relationship to the stimulated tyrosine phosphorylation of Fc_epsilon_RI .
1446976	0	tyrosine	110,118	Fc_epsilon_RII	131,145	tyrosine	Fc epsilon RII	CHEBI:18186	2208	Chemical	Gene	kinase|compound|START_ENTITY kinase|nmod|END_ENTITY	Induction of Fc_epsilon_RII / CD23 on PHA-activated human peripheral blood T lymphocytes and association of fyn tyrosine kinase with Fc_epsilon_RII / CD23 .
8161778	0	tyrosine	25,33	Fc_gamma_RIIB	76,89	tyrosine	Fc gamma RIIB	CHEBI:18186	2213	Chemical	Gene	sequences|compound|START_ENTITY sequences|nmod|END_ENTITY	Insertion of cytoplasmic tyrosine sequences into the nonphagocytic receptor Fc_gamma_RIIB establishes phagocytic function .
10352260	0	tyrosine	53,61	Fc_gamma_receptor	83,100	tyrosine	Fc gamma receptor	CHEBI:18186	2209	Chemical	Gene	phosphorylated|advmod|START_ENTITY phosphorylated|nmod|END_ENTITY	The SH2-containing_5 ' - inositol_phosphatase -LRB- SHIP -RRB- is tyrosine phosphorylated after Fc_gamma_receptor clustering in monocytes .
8419492	0	tyrosine	15,23	Fc_gamma_receptor	68,85	tyrosine	Fc gamma receptor	CHEBI:18186	2209	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Stimulation of tyrosine phosphorylation and calcium mobilization by Fc_gamma_receptor cross-linking .
8759729	0	tyrosine	158,166	Fc_mu_receptor	39,53	tyrosine	Fc mu receptor	CHEBI:18186	9214	Chemical	Gene	START_ENTITY|nsubj|association association|nmod|END_ENTITY	Physical and functional association of Fc_mu_receptor on human natural killer cells with the zeta - _ and_Fc epsilon RI gamma-chains and with src family protein tyrosine kinases .
8626653	0	tyrosine	52,60	Fc_receptor_gamma-chain	28,51	tyrosine	Fc receptor gamma-chain	CHEBI:18186	2207	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Intracluster restriction of Fc_receptor_gamma-chain tyrosine phosphorylation subverted by a protein-tyrosine phosphatase inhibitor .
9280292	0	tyrosine	70,78	Fc_receptor_gamma-chain	102,125	tyrosine	Fc receptor gamma-chain	CHEBI:18186	2207	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc_receptor_gamma-chain .
10330413	0	tyrosine	46,54	FcepsilonRI	74,85	tyrosine	FcepsilonRI	CHEBI:18186	2205	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Critical role for cholesterol in Lyn-mediated tyrosine phosphorylation of FcepsilonRI and their association with detergent-resistant membranes .
16009680	0	tyrosine	23,31	Fer	11,14	tyrosine	Fer	CHEBI:18186	14158(Tax:10090)	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Absence of Fer protein tyrosine kinase exacerbates endotoxin induced intestinal epithelial_barrier_dysfunction in vivo .
19147545	0	tyrosine	8,16	Fer	4,7	tyrosine	Fer	CHEBI:18186	2241	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The Fer tyrosine kinase cooperates with interleukin-6 to activate signal_transducer_and_activator_of_transcription_3 and promote human prostate_cancer cell growth .
19159681	0	tyrosine	85,93	Fer	81,84	tyrosine	Fer	CHEBI:18186	2241	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Hsp90 and a tyrosine embedded in the Hsp90 recognition loop are required for the Fer tyrosine kinase activity .
21268181	0	tyrosine	4,12	Fer	0,3	tyrosine	Fer	CHEBI:18186	14158(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Fer tyrosine kinase is required for germinal vesicle breakdown and meiosis-I in mouse oocytes .
23589302	0	tyrosine	8,16	Fer	4,7	tyrosine	Fer	CHEBI:18186	14158(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The Fer tyrosine kinase is important for platelet-derived growth factor-BB-induced signal transducer and activator of transcription 3 -LRB- STAT3 -RRB- protein phosphorylation , colony formation in soft agar , and tumor growth in vivo .
12435267	0	tyrosine	16,24	Fgr	0,3	tyrosine	Fgr	CHEBI:18186	2268	Chemical	Gene	kinase|amod|START_ENTITY END_ENTITY|amod|kinase	Fgr but not Syk tyrosine kinase is a target for beta 2 integrin-induced c-Cbl-mediated ubiquitination in adherent human neutrophils .
17215304	0	tyrosine	36,44	Fibroblast_growth_factor_receptor_2	0,35	tyrosine	Fibroblast growth factor receptor 2	CHEBI:18186	14183(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Fibroblast_growth_factor_receptor_2 tyrosine kinase is required for prostatic morphogenesis and the acquisition of strict androgen dependency for adult tissue homeostasis .
24446435	0	tyrosine	24,32	Fibulin_2	11,20	tyrosine	Fibulin 2	CHEBI:18186	2199	Chemical	Gene	protein|amod|START_ENTITY END_ENTITY|appos|protein	WITHDRAWN : Fibulin_2 , a tyrosine o-sulfated protein , is up-regulated following retinal_detachment .
24692557	0	tyrosine	13,21	Fibulin_2	0,9	tyrosine	Fibulin 2	CHEBI:18186	2199	Chemical	Gene	protein|amod|START_ENTITY END_ENTITY|appos|protein	Fibulin_2 , a tyrosine O-sulfated protein , is up-regulated following retinal_detachment .
15217937	0	tyrosine	28,36	Flk-1	22,27	tyrosine	Flk-1	CHEBI:18186	3791	Chemical	Gene	START_ENTITY|nsubj|study study|nmod|END_ENTITY	Phase II study of the Flk-1 tyrosine kinase inhibitor SU5416 in advanced melanoma .
15644447	0	tyrosine	42,50	Flk-1	18,23	tyrosine	Flk-1	CHEBI:18186	16542(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	Essential role of Flk-1 -LRB- VEGF_receptor_2 -RRB- tyrosine residue 1173 in vasculogenesis in mice .
9435229	0	tyrosine	66,74	Flk1	100,104	tyrosine	Flk1	CHEBI:18186	3791	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Vascular_endothelial_growth_factor_D -LRB- VEGF-D -RRB- is a ligand for the tyrosine kinases VEGF receptor 2 -LRB- Flk1 -RRB- and VEGF receptor 3 -LRB- Flt4 -RRB- .
11221852	0	tyrosine	21,29	Flt-1	15,20	tyrosine	Flt-1	CHEBI:18186	14254(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Involvement of Flt-1 tyrosine kinase -LRB- vascular_endothelial_growth_factor_receptor-1 -RRB- in pathological angiogenesis .
17379594	0	tyrosine	6,14	Flt-1	0,5	tyrosine	Flt-1	CHEBI:18186	14254(Tax:10090)	Chemical	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Flt-1 tyrosine kinase-deficient homozygous mice result in decreased trabecular bone volume with reduced osteogenic potential .
21460247	0	tyrosine	66,74	Flt-1	0,5	tyrosine	Flt-1	CHEBI:18186	2321	Chemical	Gene	regulates|ccomp|START_ENTITY regulates|nsubj|END_ENTITY	Flt-1 regulates vascular endothelial cell migration via a protein tyrosine kinase-7-dependent pathway .
7596436	0	tyrosine	27,35	Flt-1	12,17	tyrosine	Flt-1	CHEBI:18186	14254(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|receptor receptor|compound|END_ENTITY	Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium .
7657594	0	tyrosine	25,33	Flt-1	19,24	tyrosine	Flt-1	CHEBI:18186	2321	Chemical	Gene	START_ENTITY|nsubj|Interaction Interaction|nmod|END_ENTITY	Interaction of the Flt-1 tyrosine kinase receptor with the p85 subunit of phosphatidylinositol 3-kinase .
7726838	0	tyrosine	8,16	Flt-1	79,84	tyrosine	Flt-1	CHEBI:18186	2321	Chemical	Gene	kinases|compound|START_ENTITY kinases|dep|expression expression|amod|END_ENTITY	Protein tyrosine kinases expressed in glomeruli and cultured glomerular cells : Flt-1 and VEGF expression in renal mesangial cells .
8058332	0	tyrosine	140,148	Flt-1	173,178	tyrosine	Flt-1	CHEBI:18186	54251(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|family family|dep|END_ENTITY	A new communication system between hepatocytes and sinusoidal endothelial cells in liver through vascular_endothelial_growth_factor and Flt tyrosine kinase receptor family -LRB- Flt-1 and KDR/Flk -1 -RRB- .
9689083	0	tyrosine	18,26	Flt-1	0,5	tyrosine	Flt-1	CHEBI:18186	14254(Tax:10090)	Chemical	Gene	domain|amod|START_ENTITY lacking|dobj|domain END_ENTITY|acl|lacking	Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice .
9889193	0	tyrosine	165,173	Flt-1	149,154	tyrosine	Flt-1	CHEBI:18186	2321	Chemical	Gene	kinases|compound|START_ENTITY kinases|amod|VEGFR-1 VEGFR-1|dep|END_ENTITY	A novel vascular_endothelial_growth_factor encoded by Orf_virus , VEGF-E , mediates angiogenesis via signalling through VEGFR-2 -LRB- KDR -RRB- but not VEGFR-1 -LRB- Flt-1 -RRB- receptor tyrosine kinases .
11027663	0	tyrosine	20,28	Flt3	0,4	tyrosine	Flt3	CHEBI:18186	2322	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|ligand ligand|amod|END_ENTITY	Flt3 ligand induces tyrosine phosphorylation of gab1 and gab2 and their association with shp-2 , grb2 , and PI3 kinase .
15781338	0	tyrosine	11,19	Flt3	45,49	tyrosine	Flt3	CHEBI:18186	2322	Chemical	Gene	kinases|compound|START_ENTITY activated|nsubjpass|kinases activated|nmod|END_ENTITY	Src family tyrosine kinases are activated by Flt3 and are involved in the proliferative effects of leukemia-associated Flt3 mutations .
16148112	0	tyrosine	103,111	Flt3	134,138	tyrosine	Flt3	CHEBI:18186	14255(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|affinity affinity|amod|END_ENTITY	Inhibition of natural type I IFN-producing and dendritic cell development by a small molecule receptor tyrosine kinase inhibitor with Flt3 affinity .
16473406	0	tyrosine	51,59	Flt3	46,50	tyrosine	Flt3	CHEBI:18186	2322	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|amod|END_ENTITY	ATRA can enhance apoptosis that is induced by Flt3 tyrosine kinase inhibition in Flt3-ITD positive cells .
1656368	0	tyrosine	37,45	Flt3	7,11	tyrosine	Flt3	CHEBI:18186	14255(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY encoding|dobj|receptor gene|acl|encoding END_ENTITY|appos|gene	Murine Flt3 , a gene encoding a novel tyrosine kinase receptor of the PDGFR/CSF1R family .
16861351	0	tyrosine	18,26	Flt3	4,8	tyrosine	Flt3	CHEBI:18186	2322	Chemical	Gene	START_ENTITY|nsubj|receptor receptor|amod|END_ENTITY	The Flt3 receptor tyrosine kinase collaborates with NUP98-HOX fusions in acute_myeloid_leukemia .
17668209	0	tyrosine	11,19	Flt3	42,46	tyrosine	Flt3	CHEBI:18186	2322	Chemical	Gene	kinases|nsubj|START_ENTITY kinases|dobj|END_ENTITY	Src family tyrosine kinases phosphorylate Flt3 on juxtamembrane tyrosines and interfere with receptor maturation in a kinase-dependent manner .
18469816	0	tyrosine	13,21	Flt3	29,33	tyrosine	Flt3	CHEBI:18186	2322	Chemical	Gene	START_ENTITY|ccomp|required required|nsubjpass|END_ENTITY	The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues .
25795893	0	tyrosine	55,63	Flt3	50,54	tyrosine	Flt3	CHEBI:18186	14255(Tax:10090)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	O4 .2 Development of novel small molecule MerTK and Flt3 tyrosine kinase inhibitors for treatment of acute_leukemia .
7622010	0	tyrosine	19,27	Flt3	14,18	tyrosine	Flt3	CHEBI:18186	14255(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of Flt3 tyrosine kinase receptor gene in mouse hematopoietic and nervous tissues .
9918857	2	tyrosine	287,295	Flt3	312,316	tyrosine	Flt3	CHEBI:18186	2322	Chemical	Gene	kinases|compound|START_ENTITY members|nmod|kinases induces|nmod|members induces|nsubj|END_ENTITY	Like other members of type III receptor tyrosine kinases , murine Flt3 induces tyrosine phosphorylation of p85 and subsequently activation of PI3 kinase upon FL binding .
9918857	2	tyrosine	325,333	Flt3	312,316	tyrosine	Flt3	CHEBI:18186	2322	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Like other members of type III receptor tyrosine kinases , murine Flt3 induces tyrosine phosphorylation of p85 and subsequently activation of PI3 kinase upon FL binding .
8617204	0	tyrosine	114,122	Flt4	72,76	tyrosine	Flt4	CHEBI:18186	2324	Chemical	Gene	kinases|compound|START_ENTITY kinases|amod|ligand ligand|nmod|END_ENTITY	A novel vascular_endothelial_growth_factor , VEGF-C , is a ligand for the Flt4 -LRB- VEGFR-3 -RRB- and KDR -LRB- VEGFR-2 -RRB- receptor tyrosine kinases .
9435229	0	tyrosine	66,74	Flt4	127,131	tyrosine	Flt4	CHEBI:18186	2324	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Vascular_endothelial_growth_factor_D -LRB- VEGF-D -RRB- is a ligand for the tyrosine kinases VEGF receptor 2 -LRB- Flk1 -RRB- and VEGF receptor 3 -LRB- Flt4 -RRB- .
12027949	0	tyrosine	22,30	Focal_adhesion_kinase	0,21	tyrosine	Focal adhesion kinase	CHEBI:18186	14083(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Focal_adhesion_kinase tyrosine phosphorylation is associated with myogenesis and modulated by insulin .
14572803	0	tyrosine	45,53	Formyl-Met-Leu-Phe	0,18	tyrosine	Formyl-Met-Leu-Phe	CHEBI:18186	2357	Chemical	Gene	phosphorylation|compound|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Formyl-Met-Leu-Phe induces calcium-dependent tyrosine phosphorylation of Rel-1 in neutrophils .
9148902	0	tyrosine	27,35	Fpr3	88,92	tyrosine	Fpr3	CHEBI:18186	854901(Tax:4932)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Casein kinase II catalyzes tyrosine phosphorylation of the yeast nucleolar immunophilin Fpr3 .
12725532	0	tyrosine	75,83	Frk	10,13	tyrosine	Frk	CHEBI:18186	2444	Chemical	Gene	kinases|compound|START_ENTITY family|nmod|kinases form|dobj|family form|nsubj|END_ENTITY	Brk , Srm , Frk , and Src42A form a distinct family of intracellular Src-like tyrosine kinases .
20057140	0	tyrosine	73,81	Frk	69,72	tyrosine	Frk	CHEBI:18186	2444	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	A silent mutation made possible efficient production of active human Frk tyrosine kinase in Escherichia_coli .
10098840	0	tyrosine	4,12	Fyn	0,3	tyrosine	Fyn	CHEBI:18186	2534	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Fyn tyrosine kinase reduces the ethanol inhibition of recombinant NR1/NR2A but not NR1/NR2B NMDA receptors expressed in HEK 293 cells .
10358169	0	tyrosine	66,74	Fyn	0,3	tyrosine	Fyn	CHEBI:18186	2534	Chemical	Gene	phosphorylation|compound|START_ENTITY induce|dobj|phosphorylation necessary|xcomp|induce necessary|nsubj|localization localization|compound|END_ENTITY	Fyn membrane localization is necessary to induce the constitutive tyrosine phosphorylation of Sam68 in the nucleus of T lymphocytes .
10366594	0	tyrosine	77,85	Fyn	73,76	tyrosine	Fyn	CHEBI:18186	2534	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Morphological differentiation of oligodendrocytes requires activation of Fyn tyrosine kinase .
10447714	0	tyrosine	38,46	Fyn	0,3	tyrosine	Fyn	CHEBI:18186	2534	Chemical	Gene	phosphorylation|amod|START_ENTITY regulate|dobj|phosphorylation tyrosine|ccomp|regulate tyrosine|nsubj|END_ENTITY	Fyn and Lck tyrosine kinases regulate tyrosine phosphorylation of p105CasL , a member of the p130Cas docking protein family , in T-cell receptor-mediated signalling .
10458777	6	tyrosine	981,989	Fyn	1048,1051	tyrosine	TCR	CHEBI:18186	6962	Chemical	Gene	kinases|amod|START_ENTITY activated|nmod|kinases activated|nsubjpass|END_ENTITY	Among the tyrosine kinases associated with the resting TCR/CD3 complex , only Fyn is activated following CD4 engagement .
10498895	0	tyrosine	112,120	Fyn	67,70	tyrosine	Fyn	CHEBI:18186	2534	Chemical	Gene	activity|amod|START_ENTITY enhancing|dobj|activity modulates|advcl|enhancing modulates|xcomp|binding binding|nsubj|END_ENTITY	Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity .
10523617	0	tyrosine	15,23	Fyn	31,34	tyrosine	Fyn	CHEBI:18186	14360(Tax:10090)	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|ccomp|regulates regulates|nsubj|END_ENTITY	The Src family tyrosine kinase Fyn regulates natural killer T cell development .
10601038	0	tyrosine	71,79	Fyn	67,70	tyrosine	Fyn	CHEBI:18186	2534	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Compartmentalized signaling by GPI-anchored ephrin-A5 requires the Fyn tyrosine kinase to regulate cellular adhesion .
10802341	0	tyrosine	4,12	Fyn	0,3	tyrosine	Fyn	CHEBI:18186	14360(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Fyn tyrosine kinase participates in the compact myelin sheath formation in the central nervous system .
11087735	0	tyrosine	133,141	Fyn	129,132	tyrosine	Fyn	CHEBI:18186	2534	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Stimulation of M3 muscarinic receptors induces phosphorylation of the Cdc42 effector activated Cdc42Hs-associated_kinase-1 via a Fyn tyrosine kinase signaling pathway .
11162638	0	tyrosine	48,56	Fyn	10,13	tyrosine	Fyn	CHEBI:18186	2534	Chemical	Gene	residue|compound|START_ENTITY phosphorylates|nmod|residue phosphorylates|nsubj|END_ENTITY	Activated Fyn phosphorylates alpha-synuclein at tyrosine residue 125 .
11170180	0	tyrosine	4,12	Fyn	0,3	tyrosine	Fyn	CHEBI:18186	14360(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Fyn tyrosine kinase regulates oligodendroglial cell development but is not required for morphological differentiation of oligodendrocytes .
11181827	0	tyrosine	61,69	Fyn	24,27	tyrosine	Fyn	CHEBI:18186	25150(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY kinase|nmod|phosphorylation kinase|nsubj|involvement involvement|nmod|END_ENTITY	Possible involvement of Fyn kinase in ethanol-stimulated Cas tyrosine phosphorylation in rat cerebellum and cerebral cortex .
11204284	0	tyrosine	142,150	Fyn	138,141	tyrosine	Fyn	CHEBI:18186	2534	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Brain_migration_disorder and T-cell_activation_deficiency associated with abnormal signaling through TCR/CD3 complex and hyperactivity of Fyn tyrosine kinase .
11287076	0	tyrosine	27,35	Fyn	23,26	tyrosine	Fyn	CHEBI:18186	14360(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|END_ENTITY	Differential effect of Fyn tyrosine kinase deletion on offensive and defensive_aggression .
11422288	0	tyrosine	22,30	Fyn	18,21	tyrosine	Fyn	CHEBI:18186	379812(Tax:8355)	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Overexpression of Fyn tyrosine kinase causes abnormal development of primary sensory neurons in Xenopus_laevis embryos .
11751285	0	tyrosine	4,12	Fyn	0,3	tyrosine	Fyn	CHEBI:18186	14360(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Fyn tyrosine kinase in Sertoli cells is involved in mouse spermatogenesis .
11777936	0	tyrosine	4,12	Fyn	0,3	tyrosine	Fyn	CHEBI:18186	2534	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Fyn tyrosine kinase is a downstream mediator of Rho/PRK2 function in keratinocyte cell-cell adhesion .
12218089	0	tyrosine	35,43	Fyn	14,17	tyrosine	Fyn	CHEBI:18186	14360(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY essential|nmod|phosphorylation essential|nsubj|END_ENTITY	Cutting edge : Fyn is essential for tyrosine phosphorylation of Csk-binding_protein / phosphoprotein associated with glycolipid-enriched microdomains in lipid rafts in resting T cells .
12526739	0	tyrosine	4,12	Fyn	0,3	tyrosine	Fyn	CHEBI:18186	2534	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Fyn tyrosine kinase is a critical regulator of disabled-1 during brain development .
12640114	0	tyrosine	36,44	Fyn	32,35	tyrosine	Fyn	CHEBI:18186	25150(Tax:10116)	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction .
12921535	0	tyrosine	63,71	Fyn	0,3	tyrosine	Fyn	CHEBI:18186	14360(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY required|nmod|phosphorylation required|nsubjpass|END_ENTITY	Fyn is required for oxidative - and hyperosmotic-stress-induced tyrosine phosphorylation of caveolin-1 .
12966312	0	tyrosine	12,20	Fyn	8,11	tyrosine	Fyn	CHEBI:18186	14360(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of Fyn tyrosine kinase in ethanol consumption by mice .
13129934	0	tyrosine	59,67	Fyn	75,78	tyrosine	Fyn	CHEBI:18186	14360(Tax:10090)	Chemical	Gene	substrate|nmod|START_ENTITY PSD-93|nmod|substrate Identification|nmod|PSD-93 kinase|nsubj|Identification kinase|dobj|END_ENTITY	Identification of PSD-93 as a substrate for the Src family tyrosine kinase Fyn .
1337939	0	tyrosine	76,84	Fyn	24,27	tyrosine	Fyn	CHEBI:18186	14360(Tax:10090)	Chemical	Gene	kinases|compound|START_ENTITY antigen|dep|kinases expressions|appos|antigen expressions|nmod|END_ENTITY	Specific expressions of Fyn and Lyn , lymphocyte antigen receptor-associated tyrosine kinases , in the central nervous system .
14707117	0	tyrosine	80,88	Fyn	0,3	tyrosine	Fyn	CHEBI:18186	14360(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|compound|END_ENTITY	Fyn and PTP-PEST-mediated regulation of Wiskott-Aldrich_syndrome protein -LRB- WASp -RRB- tyrosine phosphorylation is required for coupling T cell antigen receptor engagement to WASp effector function and T cell activation .
14722243	0	tyrosine	108,116	Fyn	96,99	tyrosine	Fyn	CHEBI:18186	14360(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Dopamine D1-dependent trafficking of striatal N-methyl-D-aspartate_glutamate receptors requires Fyn protein tyrosine kinase but not DARPP-32 .
15044737	0	tyrosine	95,103	Fyn	91,94	tyrosine	Fyn	CHEBI:18186	2534	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The response of internal dynamics to hydrophobic core mutations in the SH3 domain from the Fyn tyrosine kinase .
15154672	0	tyrosine	88,96	Fyn	84,87	tyrosine	Fyn	CHEBI:18186	14360(Tax:10090)	Chemical	Gene	mice|compound|START_ENTITY mice|compound|END_ENTITY	Exposure to hexanal odor influences maternal behavior and induces neonatal_death in Fyn tyrosine kinase-deficient mice .
15282299	0	tyrosine	49,57	Fyn	97,100	tyrosine	Fyn	CHEBI:18186	25150(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY dependent|nmod|phosphorylation dependent|nmod|END_ENTITY	Activation of RBL-2H3 mast cells is dependent on tyrosine phosphorylation of phospholipase D2 by Fyn and Fgr .
15519689	0	tyrosine	110,118	Fyn	106,109	tyrosine	Fyn	CHEBI:18186	14360(Tax:10090)	Chemical	Gene	mice|compound|START_ENTITY mice|compound|END_ENTITY	Exposure to hexanal odor induces extraordinary Fos expression in the medial preoptic area and amygdala of Fyn tyrosine kinase-deficient mice .
15536091	0	tyrosine	35,43	Fyn	0,3	tyrosine	Fyn	CHEBI:18186	2534	Chemical	Gene	67|amod|START_ENTITY phosphorylates|nmod|67 phosphorylates|nsubj|END_ENTITY	Fyn phosphorylates human MAP-2c on tyrosine 67 .
15752743	0	tyrosine	4,12	Fyn	21,24	tyrosine	Fyn	CHEBI:18186	2534	Chemical	Gene	kinases|nsubj|START_ENTITY kinases|ccomp|favor favor|nsubj|END_ENTITY	The tyrosine kinases Fyn and Hck favor the recruitment of tyrosine-phosphorylated_APOBEC3G into vif-defective HIV-1 particles .
15831816	0	tyrosine	69,77	Fyn	51,54	tyrosine	Fyn	CHEBI:18186	2534	Chemical	Gene	kinase|compound|START_ENTITY END_ENTITY|appos|kinase	Modulation of the cardiac sodium channel NaV1 .5 by Fyn , a Src family tyrosine kinase .
15925565	0	tyrosine	128,136	Fyn	0,3	tyrosine	Fyn	CHEBI:18186	2534	Chemical	Gene	phosphorylation|amod|START_ENTITY regulation|nmod|phosphorylation pathway|dep|regulation target|nmod|pathway target|nsubj|END_ENTITY	Fyn is a downstream target of the pleiotrophin/receptor protein tyrosine phosphatase beta/zeta-signaling pathway : regulation of tyrosine phosphorylation of Fyn by pleiotrophin .
15925565	0	tyrosine	128,136	Fyn	156,159	tyrosine	Fyn	CHEBI:18186	2534	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Fyn is a downstream target of the pleiotrophin/receptor protein tyrosine phosphatase beta/zeta-signaling pathway : regulation of tyrosine phosphorylation of Fyn by pleiotrophin .
15925565	0	tyrosine	64,72	Fyn	0,3	tyrosine	Fyn	CHEBI:18186	2534	Chemical	Gene	phosphatase|amod|START_ENTITY pathway|amod|phosphatase target|nmod|pathway target|nsubj|END_ENTITY	Fyn is a downstream target of the pleiotrophin/receptor protein tyrosine phosphatase beta/zeta-signaling pathway : regulation of tyrosine phosphorylation of Fyn by pleiotrophin .
15925565	0	tyrosine	64,72	Fyn	156,159	tyrosine	Fyn	CHEBI:18186	2534	Chemical	Gene	phosphatase|amod|START_ENTITY pathway|amod|phosphatase pathway|dep|regulation regulation|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Fyn is a downstream target of the pleiotrophin/receptor protein tyrosine phosphatase beta/zeta-signaling pathway : regulation of tyrosine phosphorylation of Fyn by pleiotrophin .
16387660	3	tyrosine	590,598	Fyn	582,585	tyrosine	Fyn	CHEBI:18186	2534	Chemical	Gene	phosphorylation|amod|START_ENTITY END_ENTITY|nmod|phosphorylation	Here we show that Itch is also modulated by an Src kinase Fyn via tyrosine phosphorylation at the Tyr371 residue .
16777849	0	tyrosine	43,51	Fyn	39,42	tyrosine	Fyn	CHEBI:18186	25150(Tax:10116)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Physical and functional interaction of Fyn tyrosine kinase with a brain-enriched Rho GTPase-activating protein TCGAP .
17950286	0	tyrosine	19,27	Fyn	15,18	tyrosine	Fyn	CHEBI:18186	2534	Chemical	Gene	START_ENTITY|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of Fyn tyrosine kinase in actin stress fiber formation in fibroblasts .
17959797	0	tyrosine	73,81	Fyn	69,72	tyrosine	Fyn	CHEBI:18186	2534	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Sites and molecular mechanisms of modulation of Na -LRB- v -RRB- 1.2 channels by Fyn tyrosine kinase .
18267011	0	tyrosine	63,71	Fyn	59,62	tyrosine	Fyn	CHEBI:18186	2534	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Hepatitis_C virus NS5A protein binds the SH3 domain of the Fyn tyrosine kinase with high affinity : mutagenic analysis of residues within the SH3 domain that contribute to the interaction .
18403215	0	tyrosine	12,20	Fyn	8,11	tyrosine	Fyn	CHEBI:18186	14360(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Loss of Fyn tyrosine kinase on the C57BL/6 genetic background causes hydrocephalus with defects in oligodendrocyte development .
18691323	0	tyrosine	18,26	Fyn	14,17	tyrosine	Fyn	CHEBI:18186	14360(Tax:10090)	Chemical	Gene	hippocampus|compound|START_ENTITY hippocampus|compound|END_ENTITY	Activation of Fyn tyrosine kinase in the mouse dorsal hippocampus is essential for contextual fear conditioning .
19181669	0	tyrosine	4,12	Fyn	0,3	tyrosine	Fyn	CHEBI:18186	2534	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Fyn tyrosine kinase regulates the surface expression of glycosylphosphatidylinositol-linked ephrin via the modulation of sphingomyelin metabolism .
19441121	0	tyrosine	44,52	Fyn	40,43	tyrosine	Fyn	CHEBI:18186	2534	Chemical	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of full-length and truncated Fyn tyrosine kinase transcripts and encoded proteins during spermatogenesis and localization during acrosome biogenesis and fertilization .
20233604	0	tyrosine	26,34	Fyn	0,3	tyrosine	Fyn	CHEBI:18186	14360(Tax:10090)	Chemical	Gene	contributes|xcomp|START_ENTITY contributes|nsubj|kinase kinase|compound|END_ENTITY	Fyn kinase contributes to tyrosine phosphorylation of the GABA -LRB- A -RRB- receptor gamma2 subunit .
20506281	0	tyrosine	73,81	Fyn	0,3	tyrosine	Fyn	CHEBI:18186	14360(Tax:10090)	Chemical	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Fyn promotes phosphorylation of collapsin response mediator protein 1 at tyrosine 504 , a novel , isoform-specific regulatory site .
21919909	0	tyrosine	133,141	Fyn	28,31	tyrosine	Fyn	CHEBI:18186	25150(Tax:10116)	Chemical	Gene	redistribution|nmod|START_ENTITY associated|nmod|redistribution associated|nsubjpass|increase increase|nmod|activity activity|compound|END_ENTITY	Ethanol-induced increase in Fyn kinase activity in the dorsomedial_striatum is associated with subcellular redistribution of protein tyrosine phosphatase a .
22155429	0	tyrosine	76,84	Fyn	72,75	tyrosine	Fyn	CHEBI:18186	2534	Chemical	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Isolation of monobodies that bind specifically to the SH3 domain of the Fyn tyrosine protein kinase .
24045941	0	tyrosine	140,148	Fyn	136,139	tyrosine	Fyn	CHEBI:18186	14360(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The adaptor molecule signaling_lymphocytic_activation_molecule _ -LRB- SLAM -RRB- - associated_protein -LRB- SAP -RRB- is essential in mechanisms involving the Fyn tyrosine kinase for induction and progression of collagen-induced_arthritis .
25340851	0	tyrosine	4,12	Fyn	0,3	tyrosine	Fyn	CHEBI:18186	2534	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Fyn tyrosine kinase increases apolipoprotein_e_receptor_2 levels and phosphorylation .
25343306	0	tyrosine	88,96	Fyn	84,87	tyrosine	Fyn	CHEBI:18186	14360(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|region region|nmod|binds binds|nmod|SH3-domain SH3-domain|nmod|END_ENTITY	The proline-rich region of 18.5 kDa myelin_basic_protein binds to the SH3-domain of Fyn tyrosine kinase with the aid of an upstream segment to form a dynamic complex in vitro .
25565773	0	tyrosine	47,55	Fyn	92,95	tyrosine	Fyn	CHEBI:18186	25150(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Postsynaptic_density_protein_95-regulated NR2B tyrosine phosphorylation and interactions of Fyn with NR2B in levodopa-induced_dyskinesia rat models .
26277342	0	tyrosine	47,55	Fyn	43,46	tyrosine	Fyn	D014443	25150(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|END_ENTITY	Dopaminergic and cholinergic regulation of Fyn tyrosine kinase phosphorylation in the rat striatum in vivo .
26743129	0	tyrosine	27,35	Fyn	43,46	tyrosine	Fyn	D014443	2534	Chemical	Gene	homolog|nmod|START_ENTITY kinase|nsubj|homolog kinase|ccomp|identified identified|nsubj|END_ENTITY	A novel homolog of protein tyrosine kinase Fyn identified in Lampetra japonica with roles in the immune response .
7493751	0	tyrosine	79,87	Fyn	95,98	tyrosine	Fyn	CHEBI:18186	14360(Tax:10090)	Chemical	Gene	mice|compound|START_ENTITY mice|compound|END_ENTITY	Induction of lytic pathways in T cell clones derived from wild-type or protein tyrosine kinase Fyn mutant mice .
7544314	0	tyrosine	98,106	Fyn	94,97	tyrosine	Fyn	CHEBI:18186	14360(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Focal adhesion kinase in the brain : novel subcellular localization and specific regulation by Fyn tyrosine kinase in mutant mice .
7687536	0	tyrosine	115,123	Fyn	45,48	tyrosine	Fyn	CHEBI:18186	2534	Chemical	Gene	kinases|amod|START_ENTITY domains|nmod|kinases structures|nmod|domains comparison|nmod|structures structure|dep|comparison structure|nmod|domain domain|nmod|END_ENTITY	Crystal structure of the SH3 domain in human Fyn ; comparison of the three-dimensional structures of SH3 domains in tyrosine kinases and spectrin .
7722293	0	tyrosine	37,45	Fyn	53,56	tyrosine	Fyn	CHEBI:18186	14360(Tax:10090)	Chemical	Gene	requirement|nmod|START_ENTITY kinase|nsubj|requirement kinase|dobj|END_ENTITY	Differential requirement for protein tyrosine kinase Fyn in the functional activation of antigen-specific T lymphocyte clones through the TCR or Thy-1 .
7877449	0	tyrosine	29,37	Fyn	25,28	tyrosine	Fyn	CHEBI:18186	14360(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|fearfulness fearfulness|nmod|END_ENTITY	Increased fearfulness of Fyn tyrosine kinase deficient mice .
7961974	0	tyrosine	86,94	Fyn	66,69	tyrosine	Fyn	CHEBI:18186	2534	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Binding of the nicotinic acetylcholine receptor to SH2 domains of Fyn and Fyk protein tyrosine kinases .
8007959	0	tyrosine	119,127	Fyn	115,118	tyrosine	Fyn	CHEBI:18186	14360(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Unique catalytic properties dictate the enhanced function of p59fynT , the hemopoietic cell-specific isoform of the Fyn tyrosine protein kinase , in T cells .
8264796	0	tyrosine	15,23	Fyn	11,14	tyrosine	Fyn	CHEBI:18186	14360(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	A role for Fyn tyrosine kinase in the suckling behaviour of neonatal mice .
8545125	0	tyrosine	54,62	Fyn	42,45	tyrosine	Fyn	CHEBI:18186	2534	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Mutations in the non-catalytic domains of Fyn and Fgr tyrosine kinases reveal differences in mechanisms of their regulation .
8567733	0	tyrosine	19,27	Fyn	15,18	tyrosine	Fyn	CHEBI:18186	14360(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of Fyn tyrosine kinase in progression of cytokinesis of B lymphocyte progenitor .
8577703	0	tyrosine	86,94	Fyn	82,85	tyrosine	Fyn	CHEBI:18186	14360(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Catalytic activity of the mouse guanine_nucleotide exchanger mSOS is activated by Fyn tyrosine protein kinase and the T-cell antigen receptor in T cells .
8580083	0	tyrosine	12,20	Fyn	28,31	tyrosine	Fyn	CHEBI:18186	2534	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|ccomp|activates activates|nsubj|END_ENTITY	The protein tyrosine kinase Fyn activates transcription from the HIV promoter via activation of NF kappa B-like DNA-binding proteins .
8621719	0	tyrosine	137,145	Fyn	125,128	tyrosine	Fyn	CHEBI:18186	14360(Tax:10090)	Chemical	Gene	Grb2|compound|START_ENTITY Grb2|compound|END_ENTITY	p120cbl is a major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with Fyn and Syk tyrosine kinases , Grb2 and Shc adaptors , and the p85 subunit of phosphatidylinositol 3-kinase .
8631859	0	tyrosine	8,16	Fyn	4,7	tyrosine	Fyn	CHEBI:18186	14360(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The Fyn tyrosine kinase binds Irs-1 and forms a distinct signaling complex during insulin stimulation .
8776663	0	tyrosine	18,26	Fyn	14,17	tyrosine	Fyn	CHEBI:18186	527263(Tax:9913)	Chemical	Gene	START_ENTITY|nsubj|Activation Activation|nmod|END_ENTITY	Activation of Fyn tyrosine kinase upon secretagogue stimulation of bovine chromaffin cells .
8777897	0	tyrosine	4,12	Fyn	0,3	tyrosine	Fyn	CHEBI:18186	14360(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Fyn tyrosine kinase is required for normal amygdala kindling .
8900205	0	tyrosine	63,71	Fyn	59,62	tyrosine	Fyn	CHEBI:18186	2534	Chemical	Gene	START_ENTITY|nsubj|association association|nmod|c-Cbl c-Cbl|nmod|END_ENTITY	Specific association of tyrosine-phosphorylated c-Cbl with Fyn tyrosine kinase in T cells .
8934570	0	tyrosine	84,92	Fyn	72,75	tyrosine	Fyn	CHEBI:18186	14360(Tax:10090)	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	alpha beta T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases .
8981455	0	tyrosine	47,55	Fyn	43,46	tyrosine	Fyn	CHEBI:18186	14360(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Susceptibility Susceptibility|nmod|seizures seizures|nmod|END_ENTITY	Susceptibility to drug-induced seizures of Fyn tyrosine kinase-deficient mice .
9045636	0	tyrosine	41,49	Fyn	59,62	tyrosine	Fyn	CHEBI:18186	2534	Chemical	Gene	START_ENTITY|dobj|kinases kinases|appos|END_ENTITY	Interaction between Sam68 and Src family tyrosine kinases , Fyn and Lck , in T_cell_receptor signaling .
9089508	0	tyrosine	111,119	Fyn	86,89	tyrosine	Fyn	CHEBI:18186	2534	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Analysis of NMDA receptor mediated synaptic plasticity using gene targeting : roles of Fyn and FAK non-receptor tyrosine kinases .
9255758	0	tyrosine	47,55	Fyn	71,74	tyrosine	Fyn	CHEBI:18186	2534	Chemical	Gene	kinases|compound|START_ENTITY activities|nmod|kinases END_ENTITY|nsubj|activities	Expression and catalytic activities of protein tyrosine kinases -LRB- PTKs -RRB- Fyn and Lck in peripheral_blood_T cells from elderly humans stimulated through the T cell receptor -LRB- TCR -RRB- / CD3 complex .
9525940	0	tyrosine	65,73	Fyn	0,3	tyrosine	Fyn	CHEBI:18186	2534	Chemical	Gene	residues|amod|START_ENTITY END_ENTITY|nmod|residues	Fyn , Yes , and Syk phosphorylation sites in c-Cbl map to the same tyrosine residues that become phosphorylated in activated T cells .
9535867	0	tyrosine	30,38	Fyn	65,68	tyrosine	Fyn	CHEBI:18186	2534	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|Cbl Cbl|nmod|END_ENTITY	Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases .
9535867	0	tyrosine	77,85	Fyn	65,68	tyrosine	Fyn	CHEBI:18186	2534	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|phosphorylation phosphorylation|nmod|Cbl Cbl|nmod|END_ENTITY	Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases .
9648856	0	tyrosine	30,38	Fyn	46,49	tyrosine	Fyn	CHEBI:18186	25150(Tax:10116)	Chemical	Gene	Association|nmod|START_ENTITY kinase|nsubj|Association kinase|dobj|END_ENTITY	Association of the Src family tyrosine kinase Fyn with TrkB .
9890970	0	tyrosine	43,51	Fyn	0,3	tyrosine	Fyn	CHEBI:18186	25150(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|associates associates|compound|END_ENTITY	Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl , a binding site for phosphatidylinositol 3-kinase .
9952416	0	tyrosine	62,70	Fyn	58,61	tyrosine	Fyn	CHEBI:18186	14360(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Stimulation Stimulation|nmod|transcription transcription|nmod|END_ENTITY	Stimulation of myelin_basic_protein gene transcription by Fyn tyrosine kinase for myelination .
7522448	0	tyrosine	14,22	G-CSF	0,5	tyrosine	G-CSF	CHEBI:18186	1440	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	G-CSF induces tyrosine phosphorylation of the JAK2 protein in the human myeloid G-CSF responsive and proliferative cells , but not in mature neutrophils .
10194437	0	tyrosine	27,35	GAB1	55,59	tyrosine	GAB1	CHEBI:18186	2549	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Erythropoietin induces the tyrosine phosphorylation of GAB1 and its association with SHC , SHP2 , SHIP , and phosphatidylinositol 3-kinase .
17488287	0	tyrosine	42,50	GAPDH	2,7	tyrosine	GAPDH	CHEBI:18186	2597	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	A GAPDH mutant defective in Src-dependent tyrosine phosphorylation impedes Rab2-mediated events .
18439490	0	tyrosine	48,56	GATA4	117,122	tyrosine	GATA4	CHEBI:18186	2626	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|nmod|END_ENTITY	Retinoic_acid receptor gamma activates receptor tyrosine kinase Tie1 gene transcription through transcription factor GATA4 in F9 stem cells .
15198683	0	tyrosine	39,47	GDNF	9,13	tyrosine	GDNF	CHEBI:18186	25453(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|increases increases|compound|END_ENTITY	Striatal GDNF administration increases tyrosine hydroxylase phosphorylation in the rat striatum and substantia nigra .
12618213	8	tyrosine	1059,1067	GH	1048,1050	tyrosine	GH	CHEBI:18186	14599(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|induced induced|compound|END_ENTITY	GH induced tyrosine phosphorylation of IRS-4 and nuclear translocation of STAT5 .
15831712	5	tyrosine	760,768	GHR	788,791	tyrosine	GHR	CHEBI:18186	2690	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	After GH stimulation , tyrosine phosphorylation of GHR , JAK2 , STAT5b , and ERK1/2 increased 2 - to 10-fold .
9121492	0	tyrosine	48,56	GHR	43,46	tyrosine	GHR	CHEBI:18186	14600(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Identification Identification|appos|END_ENTITY	Identification of growth_hormone_receptor -LRB- GHR -RRB- tyrosine residues required for GHR phosphorylation and JAK2 and STAT5 activation .
9195475	0	tyrosine	24,32	GH_receptor	12,23	tyrosine	GH receptor	CHEBI:18186	2690	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	The role of GH_receptor tyrosine phosphorylation in Stat5 activation .
24764294	0	tyrosine	125,133	GIT1	119,123	tyrosine	GIT1	D014443	28964	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	Endothelial_nitric-oxide_synthase -LRB- eNOS -RRB- is activated through G-protein-coupled_receptor_kinase-interacting_protein_1 -LRB- GIT1 -RRB- tyrosine phosphorylation and Src protein .
11961407	0	tyrosine	16,24	GLEPP1	0,6	tyrosine	GLEPP1	D014443	50677(Tax:10116)	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|compound|END_ENTITY	GLEPP1 receptor tyrosine phosphatase -LRB- Ptpro -RRB- in rat PAN nephrosis .
7665166	0	tyrosine	69,77	GLEPP1	42,48	tyrosine	GLEPP1	CHEBI:18186	5800	Chemical	Gene	phosphatase|compound|START_ENTITY END_ENTITY|appos|phosphatase	Molecular cloning of cDNAs encoding human GLEPP1 , a membrane protein tyrosine phosphatase : characterization of the GLEPP1 protein distribution in human kidney and assignment of the GLEPP1 gene to human chromosome 12p12-p13 .
11170395	0	tyrosine	53,61	GLUT1	44,49	tyrosine	GLUT1	CHEBI:18186	6513	Chemical	Gene	inhibitors|amod|START_ENTITY END_ENTITY|nmod|inhibitors	Direct inhibition of the hexose transporter GLUT1 by tyrosine kinase inhibitors .
9341192	0	tyrosine	76,84	GLUT4	25,30	tyrosine	GLUT4	CHEBI:18186	6517	Chemical	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	Osmotic shock stimulates GLUT4 translocation in 3T3L1 adipocytes by a novel tyrosine kinase pathway .
8866025	0	tyrosine	19,27	GM-CSF	0,6	tyrosine	GM-CSF	CHEBI:18186	1437	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	GM-CSF induces the tyrosine phosphorylation of three isoforms of Shc and its association with Grb2 in TF-1 cell .
11054664	0	tyrosine	29,37	GRB2	100,104	tyrosine	GRB2	CHEBI:18186	2885	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Up-regulation of the protein tyrosine phosphatase SHP-1 in human breast_cancer and correlation with GRB2 expression .
15896299	0	tyrosine	101,109	GRB2	169,173	tyrosine	GRB2	CHEBI:18186	2885	Chemical	Gene	PTP1B_and_growth_factor_receptor-bound|compound|START_ENTITY complex|nmod|PTP1B_and_growth_factor_receptor-bound END_ENTITY|amod|complex	The uncovering of a novel regulatory mechanism for PLD2 : formation of a ternary complex with protein tyrosine phosphatase PTP1B_and_growth_factor_receptor-bound protein GRB2 .
17489982	8	tyrosine	1400,1408	GRB2	1377,1381	tyrosine	GC B	CHEBI:18186	4882	Chemical	Gene	found|nmod|START_ENTITY found|nmod|associate associate|nmod|END_ENTITY	The third tyrosine site -LRB- -LRB- 107 -RRB- YENV -RRB- of GCET2 is a consensus GRB2 binding site , and GCET2 was found to associate with GRB2 through the third tyrosine following phosphorylation .
7478529	0	tyrosine	108,116	GRB2	0,4	tyrosine	GRB2	CHEBI:18186	14784(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY downstream|nmod|kinase signaling|dobj|downstream endothelial|acl|signaling END_ENTITY|dep|endothelial	GRB2 and SH-PTP2 : potentially important endothelial signaling molecules downstream of the TEK/TIE2 receptor tyrosine kinase .
8780727	0	tyrosine	83,91	GRB2	155,159	tyrosine	GRB2	CHEBI:18186	2885	Chemical	Gene	START_ENTITY|acl|phosphorylated phosphorylated|dobj|protein protein|acl:relcl|binds binds|nmod|domain domain|nmod|END_ENTITY	Suc1-associated_neurotrophic_factor_target -LRB- SNT -RRB- protein is a major FGF-stimulated tyrosine phosphorylated 90-kDa protein which binds to the SH2 domain of GRB2 .
23897984	0	tyrosine	13,21	GSK-3b	45,51	tyrosine	GSK-3b	CHEBI:18186	2932	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Serine 9 and tyrosine 216 phosphorylation of GSK-3b differentially regulates autophagy in acquired cadmium resistance .
11786382	0	tyrosine	17,25	GTK	33,36	tyrosine	GTK	CHEBI:18186	14302(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY kinase|nsubj|role kinase|dobj|END_ENTITY	Dual role of the tyrosine kinase GTK and the adaptor protein SHB in beta-cell growth : enhanced beta-cell replication after 60 % pancreatectomy and increased sensitivity to streptozotocin .
11262408	0	tyrosine	38,46	Gab-1	66,71	tyrosine	Gab-1	CHEBI:18186	14388(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Roles of cell-cell adhesion-dependent tyrosine phosphorylation of Gab-1 .
10908310	0	tyrosine	154,162	Gab1	182,186	tyrosine	Gab1	CHEBI:18186	2549	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	The platelet-derived growth factor receptor stimulation of p42/p44 _ mitogen-activated_protein_kinase in airway smooth muscle involves a G-protein-mediated tyrosine phosphorylation of Gab1 .
11707404	0	tyrosine	91,99	Gab1	86,90	tyrosine	Gab1	CHEBI:18186	14388(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	ShcA and Grb2 mediate polyoma middle T antigen-induced endothelial transformation and Gab1 tyrosine phosphorylation .
25528308	0	tyrosine	24,32	Gab1	19,23	tyrosine	Gab1	CHEBI:18186	2549	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Essential roles of Gab1 tyrosine phosphorylation in growth factor-mediated signaling and angiogenesis .
11340297	0	tyrosine	26,34	Gab2	0,4	tyrosine	Gab2	CHEBI:18186	9846	Chemical	Gene	cells|amod|START_ENTITY phosphorylated|nmod|cells phosphorylated|nsubjpass|END_ENTITY	Gab2 is phosphorylated on tyrosine upon interleukin-2 / interleukin-15 stimulation in mycosis-fungoides-derived tumor T cells and associates inducibly with SHP-2 and Stat5a .
12595575	0	tyrosine	5,13	Gab2	0,4	tyrosine	Gab2	CHEBI:18186	84477(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Gab2 tyrosine phosphorylation by a pleckstrin homology domain-independent mechanism : role in epidermal_growth_factor-induced mitogenesis .
14656892	0	tyrosine	14,22	Gab2	42,46	tyrosine	Gab2	CHEBI:18186	14389(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	G-CSF-induced tyrosine phosphorylation of Gab2 is Lyn kinase dependent and associated with enhanced Akt and differentiative , not proliferative , responses .
9160883	0	tyrosine	93,101	Gas6	18,22	tyrosine	Gas6	CHEBI:18186	2621	Chemical	Gene	kinase|compound|START_ENTITY END_ENTITY|nmod|kinase	Identification of Gas6 as a ligand for Mer , a neural cell adhesion molecule related receptor tyrosine kinase implicated in cellular transformation .
8549807	0	tyrosine	16,24	Gastrin	0,7	tyrosine	Gastrin	CHEBI:18186	2520	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Gastrin induces tyrosine phosphorylation of Shc proteins and their association with the Grb2/Sos complex .
8824290	0	tyrosine	19,27	Gastrin	0,7	tyrosine	Gastrin	CHEBI:18186	2520	Chemical	Gene	phosphorylation|amod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Gastrin stimulates tyrosine phosphorylation of insulin_receptor_substrate_1 and its association with Grb2 and the phosphatidylinositol 3-kinase .
23585298	0	tyrosine	95,103	GluN2B	83,89	tyrosine	GluN2B	CHEBI:18186	24410(Tax:10116)	Chemical	Gene	site|compound|START_ENTITY site|compound|END_ENTITY	Synaptic non-GluN2B-containing NMDA receptors regulate tyrosine phosphorylation of GluN2B 1472 tyrosine site in rat brain slices .
15519688	0	tyrosine	51,59	GluR1	105,110	tyrosine	GluR1	CHEBI:18186	2890	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Brain-derived_neurotrophic_factor acutely enhances tyrosine phosphorylation of the AMPA receptor subunit GluR1 via NMDA receptor-dependent mechanisms .
1571555	0	tyrosine	85,93	Granulocyte-macrophage_colony-stimulating_factor	0,48	tyrosine	Granulocyte-macrophage colony-stimulating factor	CHEBI:18186	1437	Chemical	Gene	phosphorylation|compound|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Granulocyte-macrophage_colony-stimulating_factor induces a staurosporine inhibitable tyrosine phosphorylation of unique neutrophil proteins .
21791607	0	tyrosine	67,75	Grb14	15,20	tyrosine	Grb14	CHEBI:18186	2888	Chemical	Gene	inhibitor|nmod|START_ENTITY inhibitor|nsubj|END_ENTITY	Phosphorylated Grb14 is an endogenous inhibitor of retinal protein tyrosine phosphatase 1B , and light-dependent activation of Src phosphorylates Grb14 .
10085221	0	tyrosine	12,20	Grb2	40,44	tyrosine	Grb2	CHEBI:18186	81504(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Gi-mediated tyrosine phosphorylation of Grb2 -LRB- growth-factor-receptor-bound_protein_2 -RRB- - bound dynamin-II by lysophosphatidic_acid .
10490839	0	tyrosine	52,60	Grb2	128,132	tyrosine	Grb2	CHEBI:18186	2885	Chemical	Gene	epsilon|amod|START_ENTITY forms|nmod|epsilon associate|nsubj|forms associate|nmod|END_ENTITY	The transmembranal and cytoplasmic forms of protein tyrosine phosphatase epsilon physically associate with the adaptor molecule Grb2 .
10748052	0	tyrosine	122,130	Grb2	48,52	tyrosine	Grb2	CHEBI:18186	81504(Tax:10116)	Chemical	Gene	kinase|compound|START_ENTITY tyrosines|nmod|kinase tyrosines|nsubj|binding binding|nmod|END_ENTITY	Direct binding of the signaling adapter protein Grb2 to the activation loop tyrosines on the nerve growth factor receptor tyrosine kinase , TrkA .
10749687	0	tyrosine	70,78	Grb2	227,231	tyrosine	Grb2	CHEBI:18186	2885	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|amod|dependent dependent|nmod|integrin integrin|acl|translocation translocation|nmod|END_ENTITY	Involvement of proline-rich_tyrosine_kinase_2 in platelet activation : tyrosine phosphorylation mostly dependent on alphaIIbbeta3 integrin and protein kinase C , translocation to the cytoskeleton and association with Shc through Grb2 .
10887132	0	tyrosine	116,124	Grb2	4,8	tyrosine	Grb2	CHEBI:18186	14784(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY required|nmod|kinase required|nsubjpass|site site|amod|END_ENTITY	The Grb2 binding site is required for the induction of chronic_myeloid_leukemia-like disease in mice by the Bcr/Abl tyrosine kinase .
10913131	0	tyrosine	173,181	Grb2	30,34	tyrosine	Grb2	CHEBI:18186	2885	Chemical	Gene	kinases|dep|START_ENTITY reveals|xcomp|kinases reveals|nsubj|Identification Identification|nmod|site site|amod|END_ENTITY	Identification of an atypical Grb2 carboxyl-terminal SH3 domain binding site in Gab docking proteins reveals Grb2-dependent and - independent recruitment of Gab1 to receptor tyrosine kinases .
11726515	0	tyrosine	115,123	Grb2	28,32	tyrosine	Grb2	CHEBI:18186	2885	Chemical	Gene	signaling|amod|START_ENTITY mechanism|nmod|signaling phosphorylation|dep|mechanism phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of Grb2 by Bcr/Abl and epidermal_growth_factor_receptor : a novel regulatory mechanism for tyrosine kinase signaling .
11896612	0	tyrosine	32,40	Grb2	99,103	tyrosine	Grb2	CHEBI:18186	2885	Chemical	Gene	START_ENTITY|ccomp|reveals reveals|ccomp|sufficient sufficient|nsubj|downstream downstream|nmod|END_ENTITY	Use of signal specific receptor tyrosine kinase oncoproteins reveals that pathways downstream from Grb2 or Shc are sufficient for cell transformation and metastasis .
15143164	0	tyrosine	106,114	Grb2	26,30	tyrosine	Grb2	CHEBI:18186	14784(Tax:10090)	Chemical	Gene	kinase|amod|START_ENTITY contributes|nmod|kinase contributes|nsubj|site site|nmod|END_ENTITY	A direct binding site for Grb2 contributes to transformation and leukemogenesis by the Tel-Abl -LRB- ETV6-Abl -RRB- tyrosine kinase .
18258597	0	tyrosine	94,102	Grb2	162,166	tyrosine	Grb2	CHEBI:18186	81504(Tax:10116)	Chemical	Gene	kinase|compound|START_ENTITY tyrosine-phosphorylated|nmod|kinase tyrosine-phosphorylated|xcomp|signaling signaling|nmod|END_ENTITY	Neph1 , a component of the kidney slit diaphragm , is tyrosine-phosphorylated by the Src family tyrosine kinase and modulates intracellular signaling by binding to Grb2 .
19815557	0	tyrosine	52,60	Grb2	84,88	tyrosine	Grb2	CHEBI:18186	2885	Chemical	Gene	kinases|compound|START_ENTITY interaction|nmod|kinases mediated|nsubjpass|interaction mediated|nmod|END_ENTITY	Cytoplasmic ACK1 interaction with multiple receptor tyrosine kinases is mediated by Grb2 : an analysis of ACK1 effects on Axl signaling .
20398064	0	tyrosine	61,69	Grb2	117,121	tyrosine	Grb2	CHEBI:18186	2885	Chemical	Gene	phosphatases|compound|START_ENTITY subtype|dobj|phosphatases subtype|nmod|END_ENTITY	Tyrosine phosphorylation of R3 subtype receptor-type protein tyrosine phosphatases and their complex formations with Grb2 or Fyn .
20498059	0	tyrosine	65,73	Grb2	0,4	tyrosine	Grb2	D014443	2885	Chemical	Gene	top|nmod|START_ENTITY functions|nmod|top functions|amod|END_ENTITY	Grb2 functions at the top of the T-cell_antigen_receptor-induced tyrosine kinase cascade to control thymic selection .
23131845	0	tyrosine	39,47	Grb2	0,4	tyrosine	Grb2	CHEBI:18186	2885	Chemical	Gene	sword|nmod|START_ENTITY kinase|nsubj|sword kinase|advmod|END_ENTITY	Grb2 , a double-edged sword of receptor tyrosine kinase signaling .
7518443	0	tyrosine	9,17	Grb2	109,113	tyrosine	Grb2	CHEBI:18186	2885	Chemical	Gene	R-PTP-alpha|compound|START_ENTITY tyrosine-phosphorylated|nsubjpass|R-PTP-alpha tyrosine-phosphorylated|nmod|END_ENTITY	Receptor tyrosine phosphatase R-PTP-alpha is tyrosine-phosphorylated and associated with the adaptor protein Grb2 .
7522233	0	tyrosine	94,102	Grb2	163,167	tyrosine	Grb2	CHEBI:18186	2885	Chemical	Gene	phosphorylation|dep|START_ENTITY phosphorylation|nmod|SHPTP2 SHPTP2|nmod|END_ENTITY	Interleukin -LRB- IL -RRB- -3 and granulocyte/macrophage _ colony-stimulating_factor , but not IL-4 , induce tyrosine phosphorylation , activation , and association of SHPTP2 with Grb2 and phosphatidylinositol 3 ' - kinase .
7564569	0	tyrosine	6,14	Grb2	34,38	tyrosine	Grb2	CHEBI:18186	14784(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Rapid tyrosine phosphorylation of Grb2 and Shc in T cells exposed to anti-CD3 , anti-CD4 , and anti-CD45 stimuli : differential effects of aging .
8063801	0	tyrosine	101,109	Grb2	23,27	tyrosine	Grb2	CHEBI:18186	2885	Chemical	Gene	substrate|nmod|START_ENTITY kinase|nsubj|substrate kinase|nmod|association association|nmod|END_ENTITY	In vivo association of Grb2 with pp116 , a substrate of the T cell antigen receptor-activated protein tyrosine kinase .
8479536	0	tyrosine	67,75	Grb2	45,49	tyrosine	Grb2	CHEBI:18186	14784(Tax:10090)	Chemical	Gene	transduction|amod|START_ENTITY implicated|nmod|transduction implicated|nsubjpass|Association Association|nmod|protein protein|nmod|END_ENTITY	Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation .
8703035	0	tyrosine	135,143	Grb2	97,101	tyrosine	Grb2	CHEBI:18186	2885	Chemical	Gene	kinase|compound|START_ENTITY site|nmod|kinase site|amod|binding binding|nmod:npmod|END_ENTITY	Branching tubulogenesis but not scatter of madin-darby canine kidney cells requires a functional Grb2 binding site in the Met receptor tyrosine kinase .
8824290	0	tyrosine	19,27	Grb2	101,105	tyrosine	Grb2	CHEBI:18186	2885	Chemical	Gene	phosphorylation|amod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nmod|END_ENTITY	Gastrin stimulates tyrosine phosphorylation of insulin_receptor_substrate_1 and its association with Grb2 and the phosphatidylinositol 3-kinase .
8943348	0	tyrosine	19,27	Grb2	112,116	tyrosine	Grb2	CHEBI:18186	2885	Chemical	Gene	receptor|amod|START_ENTITY Phosphorylation|nmod|receptor required|nsubjpass|Phosphorylation required|nmod|binding binding|nmod|END_ENTITY	Phosphorylation of tyrosine 720 in the platelet-derived growth factor alpha receptor is required for binding of Grb2 and SHP-2 but not for activation of Ras or cell proliferation .
8959326	0	tyrosine	32,40	Grb2	78,82	tyrosine	Grb2	CHEBI:18186	2885	Chemical	Gene	SHP-2|amod|START_ENTITY engages|nsubj|SHP-2 engages|xcomp|binding binding|nmod|END_ENTITY	Multiple in vivo phosphorylated tyrosine phosphatase SHP-2 engages binding to Grb2 via tyrosine 584 .
8959326	0	tyrosine	87,95	Grb2	78,82	tyrosine	Grb2	CHEBI:18186	2885	Chemical	Gene	584|amod|START_ENTITY END_ENTITY|nmod|584	Multiple in vivo phosphorylated tyrosine phosphatase SHP-2 engages binding to Grb2 via tyrosine 584 .
9135065	0	tyrosine	31,39	Grb2	167,171	tyrosine	Grb2	CHEBI:18186	14784(Tax:10090)	Chemical	Gene	phosphatase|compound|START_ENTITY Coupling|nmod|phosphatase PEST|nsubj|Coupling PEST|nmod|association association|nmod|END_ENTITY	Coupling of the murine protein tyrosine phosphatase PEST to the epidermal_growth_factor _ -LRB- EGF -RRB- _ receptor through a Src homology 3 -LRB- SH3 -RRB- domain-mediated association with Grb2 .
9252406	0	tyrosine	148,156	Grb2	120,124	tyrosine	Grb2	CHEBI:18186	2885	Chemical	Gene	1356|amod|START_ENTITY site|nmod|1356 site|amod|binding binding|nmod:npmod|END_ENTITY	Association of the multisubstrate docking protein Gab1 with the hepatocyte growth factor receptor requires a functional Grb2 binding site involving tyrosine 1356 .
9368064	0	tyrosine	25,33	Grb2	103,107	tyrosine	Grb2	CHEBI:18186	2885	Chemical	Gene	dephosphorylation|amod|START_ENTITY stimulate|dobj|dephosphorylation stimulate|nmod|domain domain|nmod|END_ENTITY	Growth factors stimulate tyrosine dephosphorylation of p75 and its dissociation from the SH2 domain of Grb2 .
9380408	0	tyrosine	58,66	Grb2	27,31	tyrosine	Grb2	CHEBI:18186	14784(Tax:10090)	Chemical	Gene	site|nmod|START_ENTITY site|amod|END_ENTITY	Identification of a second Grb2 binding site in the v-Fms tyrosine kinase .
9764818	0	tyrosine	46,54	Grb2	0,4	tyrosine	Grb2	CHEBI:18186	2885	Chemical	Gene	kinase|amod|START_ENTITY isoforms|nmod|kinase binding|nmod|isoforms END_ENTITY|xcomp|binding	Grb2 binding to the different isoforms of Ret tyrosine kinase .
9830057	0	tyrosine	130,138	Grb2	121,125	tyrosine	Grb2	CHEBI:18186	100769627	Chemical	Gene	350|amod|START_ENTITY association|nmod|350 association|nmod|END_ENTITY	Insulin stimulates sequestration of beta-adrenergic receptors and enhanced association of beta-adrenergic receptors with Grb2 via tyrosine 350 .
9891051	0	tyrosine	37,45	Grb2	90,94	tyrosine	Grb2	CHEBI:18186	14784(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY effects|nmod|kinase depend|nsubj|effects depend|nmod|site site|amod|END_ENTITY	Biological effects of c-Mer receptor tyrosine kinase in hematopoietic cells depend on the Grb2 binding site in the receptor and activation of NF-kappaB .
11940581	0	tyrosine	94,102	Grb2-associated_binder-1	69,93	tyrosine	Grb2-associated binder-1	CHEBI:18186	100753832	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Protein_kinase_C-alpha and protein_kinase_C-epsilon are required for Grb2-associated_binder-1 tyrosine phosphorylation in response to platelet-derived growth factor .
23521888	0	tyrosine	46,54	Grb2-associated_binder_1	86,110	tyrosine	Grb2-associated binder 1	CHEBI:18186	14388(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Protein_tyrosine_phosphatase-1B regulates the tyrosine phosphorylation of the adapter Grb2-associated_binder_1 -LRB- Gab1 -RRB- in the retina .
10486260	0	tyrosine	26,34	Growth_hormone	0,14	tyrosine	Growth hormone	CHEBI:18186	2688	Chemical	Gene	phosphorylation|amod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Growth_hormone stimulates tyrosine phosphorylation of focal adhesion kinase -LRB- p125 -LRB- FAK -RRB- -RRB- and actin stress fiber formation in human osteoblast-like cells , Saos2 .
1537856	0	tyrosine	30,38	Growth_hormone	0,14	tyrosine	Growth hormone	CHEBI:18186	2688	Chemical	Gene	phosphorylation|amod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Growth_hormone stimulates the tyrosine phosphorylation of 42 - and 45-kDa ERK-related proteins .
7848524	0	tyrosine	23,31	Growth_hormone	0,14	tyrosine	Growth hormone	CHEBI:18186	2688	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Growth_hormone induces tyrosine phosphorylation but does not alter insulin-like growth factor-I gene expression in human IM9 lymphocytes .
7876077	0	tyrosine	30,38	Growth_hormone	0,14	tyrosine	Growth hormone	CHEBI:18186	81668(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Growth_hormone stimulates the tyrosine phosphorylation of the insulin_receptor_substrate-1 and its association with phosphatidylinositol 3-kinase in primary adipocytes .
8174702	0	tyrosine	27,35	Growth_hormone	0,14	tyrosine	Growth hormone	CHEBI:18186	2688	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Growth_hormone induces the tyrosine phosphorylation and nuclear accumulation of components of the ISGF3 transcription factor complex .
8770909	0	tyrosine	26,34	Growth_hormone	0,14	tyrosine	Growth hormone	CHEBI:18186	81668(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Growth_hormone stimulates tyrosine phosphorylation of JAK2 and STAT5 , but not insulin_receptor_substrate-1 or SHC proteins in liver and skeletal muscle of normal rats in vivo .
8828496	0	tyrosine	23,31	Growth_hormone	0,14	tyrosine	Growth hormone	CHEBI:18186	81668(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Growth_hormone induces tyrosine phosphorylation of annexin_I in rat_osteosarcoma cells .
9553131	0	tyrosine	30,38	Growth_hormone	0,14	tyrosine	Growth hormone	CHEBI:18186	14599(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Growth_hormone stimulates the tyrosine phosphorylation and association of p125 focal_adhesion_kinase -LRB- FAK -RRB- with JAK2 .
9886807	0	tyrosine	30,38	Growth_hormone	0,14	tyrosine	Growth hormone	CHEBI:18186	81668(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	Growth_hormone stimulates the tyrosine kinase activity of JAK2 and induces tyrosine phosphorylation of insulin_receptor substrates and Shc in rat tissues .
19340315	0	tyrosine	35,43	HD-PTP	0,6	tyrosine	HD-PTP	CHEBI:18186	25930	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|nsubj|END_ENTITY	HD-PTP is a catalytically inactive tyrosine phosphatase due to a conserved divergence in its phosphatase domain .
12502359	1	tyrosine	166,174	HER-2	288,293	tyrosine	HER-2	CHEBI:18186	2064	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|epidermal_growth_factor_receptor epidermal_growth_factor_receptor|appos|END_ENTITY	The design of an orally active , irreversible inhibitor of the tyrosine kinase activity of the epidermal_growth_factor_receptor -LRB- EGFR -RRB- and the human epidermal_growth_factor_receptor-2 -LRB- HER-2 -RRB- .
14505676	0	tyrosine	88,96	HER-2	72,77	tyrosine	HER-2	CHEBI:18186	2064	Chemical	Gene	kinases|amod|START_ENTITY kinases|amod|END_ENTITY	Adenosine-anchored triphosphate subsite probing : distinguishing between HER-2 and HER-4 tyrosine protein kinases .
14751502	4	tyrosine	1078,1086	HER2	1073,1077	tyrosine	EGFR	CHEBI:18186	1956	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	RESULTS : GW572016 inhibited constitutive and/or ligand-induced EGFR or HER2 tyrosine phosphorylation of all five cell lines , which correlated with the antiproliferative response in all but one cell line .
15899817	0	tyrosine	92,100	HER2	0,4	tyrosine	HER2	CHEBI:18186	2064	Chemical	Gene	inhibitor|amod|START_ENTITY gefitinib|appos|inhibitor sensitivity|nmod|gefitinib sensitivity|nsubj|increases increases|compound|END_ENTITY	HER2 overexpression increases sensitivity to gefitinib , an epidermal_growth_factor_receptor tyrosine kinase inhibitor , through inhibition of HER2/HER3 heterodimer formation in lung_cancer cells .
16771730	0	tyrosine	21,29	HER2	6,10	tyrosine	HER2	CHEBI:18186	2064	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	Novel HER2 selective tyrosine kinase inhibitor , TAK-165 , inhibits bladder , _ kidney_and_androgen-independent_prostate_cancer in vitro and in vivo .
17143483	0	tyrosine	31,39	HER2	26,30	tyrosine	HER2	CHEBI:18186	2064	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Geldanamycin destabilizes HER2 tyrosine kinase and suppresses Wnt/beta-catenin signaling in HER2 overexpressing human breast_cancer cells .
17143483	0	tyrosine	31,39	HER2	92,96	tyrosine	HER2	CHEBI:18186	2064	Chemical	Gene	kinase|compound|START_ENTITY kinase|acl|signaling signaling|nmod|END_ENTITY	Geldanamycin destabilizes HER2 tyrosine kinase and suppresses Wnt/beta-catenin signaling in HER2 overexpressing human breast_cancer cells .
17174554	0	tyrosine	94,102	HER2	89,93	tyrosine	HER2	CHEBI:18186	2064	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Synthesis and biological evaluation of 4-aryl-5-cyano-2H-1 ,2,3 - triazoles as inhibitor of HER2 tyrosine kinase .
18026190	0	tyrosine	135,143	HER2	129,133	tyrosine	HER2	CHEBI:18186	2064	Chemical	Gene	START_ENTITY|nsubj|study study|appos|END_ENTITY	A phase I dose escalation study of BIBW_2992 , an irreversible dual inhibitor of epidermal growth factor receptor 1 -LRB- EGFR -RRB- and 2 -LRB- HER2 -RRB- tyrosine kinase in a 2-week on , 2-week off schedule in patients with advanced solid tumours .
18283037	0	tyrosine	124,132	HER2	119,123	tyrosine	HER2	CHEBI:18186	2064	Chemical	Gene	inhibitor|compound|START_ENTITY inhibitor|compound|END_ENTITY	Low-scale phosphoproteome analyses identify the mTOR effector p70 S6 kinase 1 as a specific biomarker of the dual-HER1 / HER2 tyrosine kinase inhibitor lapatinib -LRB- Tykerb -RRB- in human breast_carcinoma cells .
18682844	0	tyrosine	37,45	HER2	0,4	tyrosine	HER2	CHEBI:18186	2064	Chemical	Gene	inhibitors|amod|START_ENTITY escapes|dobj|inhibitors escapes|nsubj|function function|nummod|END_ENTITY	HER2 oncogenic function escapes EGFR tyrosine kinase inhibitors via activation of alternative HER receptors in breast_cancer cells .
18814184	0	tyrosine	4,12	HER2	29,33	tyrosine	HER2	CHEBI:18186	13866(Tax:10090)	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|dobj|END_ENTITY	The tyrosine kinase receptor HER2 -LRB- erbB-2 -RRB- : from oncogenesis to adipogenesis .
19060928	0	tyrosine	18,26	HER2	13,17	tyrosine	HER2	CHEBI:18186	2064	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	Lapatinib , a HER2 tyrosine kinase inhibitor , induces stabilization and accumulation of HER2 and potentiates trastuzumab-dependent cell cytotoxicity .
19060928	0	tyrosine	18,26	HER2	87,91	tyrosine	HER2	CHEBI:18186	2064	Chemical	Gene	inhibitor|amod|START_ENTITY Lapatinib|appos|inhibitor induces|nsubj|Lapatinib induces|dobj|stabilization stabilization|nmod|END_ENTITY	Lapatinib , a HER2 tyrosine kinase inhibitor , induces stabilization and accumulation of HER2 and potentiates trastuzumab-dependent cell cytotoxicity .
19082476	0	tyrosine	259,267	HER2	287,291	tyrosine	HER2	CHEBI:18186	2064	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Extra-virgin olive oil polyphenols inhibit HER2 -LRB- erbB-2 -RRB- - induced malignant transformation in human breast epithelial cells : relationship between the chemical structures of extra-virgin olive oil secoiridoids and lignans and their inhibitory activities on the tyrosine kinase activity of HER2 .
19239686	0	tyrosine	41,49	HER2	17,21	tyrosine	HER2	CHEBI:18186	2064	Chemical	Gene	1221/1222|amod|START_ENTITY phosphorylation|nmod|1221/1222 phosphorylation|nummod|END_ENTITY	Determination of HER2 phosphorylation at tyrosine 1221/1222 improves prediction of poor survival for breast_cancer patients with hormone receptor-positive tumors .
19289058	0	tyrosine	58,66	HER2	53,57	tyrosine	HER2	CHEBI:18186	2064	Chemical	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	Atomistic insights into regulatory mechanisms of the HER2 tyrosine kinase domain : a molecular dynamics study .
19529774	0	tyrosine	32,40	HER2	27,31	tyrosine	HER2	CHEBI:18186	2064	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|nummod|END_ENTITY	Lapatinib , a dual EGFR and HER2 tyrosine kinase inhibitor , downregulates thymidylate_synthase by inhibiting the nuclear translocation of EGFR and HER2 .
19574203	0	tyrosine	142,150	HER2	137,141	tyrosine	HER2	CHEBI:18186	2064	Chemical	Gene	lapatinib|amod|START_ENTITY lapatinib|compound|END_ENTITY	mTOR inhibitors and the anti-diabetic biguanide_metformin : new insights into the molecular management of breast_cancer resistance to the HER2 tyrosine kinase inhibitor lapatinib -LRB- Tykerb -RRB- .
20413845	0	tyrosine	22,30	HER2	47,51	tyrosine	HER2	CHEBI:18186	2064	Chemical	Gene	phosphatases|amod|START_ENTITY phosphatases|nmod|END_ENTITY	Expression profile of tyrosine phosphatases in HER2 breast_cancer_cells_and_tumors .
20658522	0	tyrosine	28,36	HER2	82,86	tyrosine	HER2	CHEBI:18186	2064	Chemical	Gene	inhibitor|compound|START_ENTITY Lapatinib|appos|inhibitor augments|nsubj|Lapatinib augments|dobj|cleavage cleavage|nmod|domain domain|compound|END_ENTITY	Lapatinib , a dual HER1/HER2 tyrosine kinase inhibitor , augments basal cleavage of HER2 extracellular domain -LRB- ECD -RRB- to inhibit HER2-driven cancer cell growth .
21385943	0	tyrosine	107,115	HER2	102,106	tyrosine	HER2	CHEBI:18186	2064	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Transcriptional and posttranslational up-regulation of HER3 -LRB- ErbB3 -RRB- compensates for inhibition of the HER2 tyrosine kinase .
21499296	0	tyrosine	90,98	HER2	85,89	tyrosine	HER2	CHEBI:18186	2064	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|compound|END_ENTITY	Phosphoproteomic mass spectrometry profiling links Src family kinases to escape from HER2 tyrosine kinase inhibition .
21851234	0	tyrosine	111,119	HER2	106,110	tyrosine	HER2	CHEBI:18186	2064	Chemical	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Characterization of novel murine monoclonal antibodies directed against the extracellular domain of human HER2 tyrosine kinase receptor .
22761469	0	tyrosine	83,91	HER2	77,81	tyrosine	HER2	CHEBI:18186	2064	Chemical	Gene	START_ENTITY|nsubj|associations associations|appos|END_ENTITY	Prevalence , clinicopathologic associations , and molecular spectrum of ERBB2 -LRB- HER2 -RRB- tyrosine kinase mutations in lung_adenocarcinomas .
23062209	0	tyrosine	40,48	HER2	17,21	tyrosine	HER2	CHEBI:18186	2064	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Co-expression of HER2 and HER3 receptor tyrosine kinases enhances invasion of breast cells via stimulation of interleukin-8 autocrine secretion .
23358664	0	tyrosine	46,54	HER2	41,45	tyrosine	HER2	CHEBI:18186	2064	Chemical	Gene	kinase|amod|START_ENTITY kinase|nummod|END_ENTITY	HER2-targeted hybrid peptide that blocks HER2 tyrosine kinase disintegrates cancer cell membrane and inhibits tumor growth in vivo .
25899785	0	tyrosine	96,104	HER2	10,14	tyrosine	HER2	D014443	2064	Chemical	Gene	dacomitinib|amod|START_ENTITY trial|nmod|dacomitinib aberrations|dep|trial aberrations|compound|END_ENTITY	Targeting HER2 aberrations as actionable drivers in lung_cancers : phase II trial of the pan-HER tyrosine kinase inhibitor dacomitinib in patients with HER2-mutant or amplified tumors .
26337386	0	tyrosine	67,75	HER2	53,57	tyrosine	HER2	D014443	13866(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|responses responses|nmod|receptor receptor|compound|END_ENTITY	Microenvironment_rigidity modulates responses to the HER2 receptor tyrosine kinase inhibitor lapatinib via YAP and TAZ transcription factors .
26391018	0	tyrosine	105,113	HER2	59,63	tyrosine	HER2	D014443	2064	Chemical	Gene	tyrosine|xcomp|START_ENTITY tyrosine|nsubj|analysis analysis|nmod|resistance resistance|nmod|receptor receptor|compound|END_ENTITY	A systematic analysis of the resistance and sensitivity of HER2 -LRB- YVMA -RRB- receptor tyrosine kinase mutant to tyrosine kinase inhibitors in HER2-positive lung_cancer .
26391018	0	tyrosine	79,87	HER2	59,63	tyrosine	HER2	D014443	2064	Chemical	Gene	START_ENTITY|nsubj|analysis analysis|nmod|resistance resistance|nmod|receptor receptor|compound|END_ENTITY	A systematic analysis of the resistance and sensitivity of HER2 -LRB- YVMA -RRB- receptor tyrosine kinase mutant to tyrosine kinase inhibitors in HER2-positive lung_cancer .
22802413	0	tyrosine	21,29	HGF_receptor	4,16	tyrosine	HGF receptor	CHEBI:18186	17295(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The HGF_receptor / Met tyrosine kinase is a key regulator of dendritic cell migration in skin immunity .
8601419	0	tyrosine	113,121	HGF_receptor	145,157	tyrosine	HGF receptor	CHEBI:18186	4233	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Hepatocyte_growth_factor -LRB- HGF -RRB- - induced cell migration is negatively modulated by epidermal_growth_factor through tyrosine phosphorylation of the HGF_receptor .
9754558	0	tyrosine	46,54	HLA_B27	84,91	tyrosine	HLA B27	CHEBI:18186	3106	Chemical	Gene	Importance|nmod|START_ENTITY Importance|nmod|END_ENTITY	Importance of a conserved TCR J alpha-encoded tyrosine for T cell recognition of an HLA_B27 / peptide complex .
20615403	0	tyrosine	26,34	HLJ1	54,58	tyrosine	HLJ1	CHEBI:18186	11080	Chemical	Gene	START_ENTITY|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Acidic stress facilitates tyrosine phosphorylation of HLJ1 to associate with actin cytoskeleton in lung_cancer cells .
22308320	0	tyrosine	4,12	HNF4a	56,61	tyrosine	HNF4a	CHEBI:18186	3172	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Src tyrosine kinase phosphorylation of nuclear receptor HNF4a correlates with isoform-specific loss of HNF4a in human colon_cancer .
1915292	0	tyrosine	26,34	HPTP_alpha	47,57	tyrosine	HPTP alpha	CHEBI:18186	5786	Chemical	Gene	phosphatase|nsubj|START_ENTITY phosphatase|ccomp|has has|nsubj|END_ENTITY	The receptor-like protein tyrosine phosphatase HPTP_alpha has two active catalytic domains with distinct substrate specificities .
24123531	0	tyrosine	70,78	HRAS	0,4	tyrosine	HRAS	CHEBI:18186	3265	Chemical	Gene	START_ENTITY|nsubj|mutations mutations|compound|END_ENTITY	HRAS mutations and resistance to the epidermal_growth_factor_receptor tyrosine kinase inhibitor erlotinib in head_and_neck_squamous_cell_carcinoma cells .
15795233	0	tyrosine	17,25	HS1	45,48	tyrosine	HS1	CHEBI:18186	3059	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Thrombin-induced tyrosine phosphorylation of HS1 in human platelets is sequentially catalyzed by Syk and Lyn tyrosine kinases and associated with the cellular migration of the protein .
9230709	0	tyrosine	6,14	HS1	34,37	tyrosine	HS1	CHEBI:18186	15163(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Rapid tyrosine phosphorylation of HS1 in the response of mouse_lymphoma L5178Y-R cells to photodynamic treatment sensitized by the phthalocyanine Pc_4 .
10221518	0	tyrosine	23,31	HTK	39,42	tyrosine	HTK	CHEBI:18186	2050	Chemical	Gene	Expression|nmod|START_ENTITY kinase|nsubj|Expression kinase|dobj|END_ENTITY	Expression of receptor tyrosine kinase HTK -LRB- hepatoma_transmembrane_kinase -RRB- and HTK_ligand by human leukemia-lymphoma cell lines .
8134117	0	tyrosine	42,50	HYL	59,62	tyrosine	HYL	CHEBI:18186	4145	Chemical	Gene	START_ENTITY|dobj|kinase kinase|appos|END_ENTITY	Molecular cloning of a novel non-receptor tyrosine kinase , HYL -LRB- hematopoietic_consensus_tyrosine-lacking_kinase -RRB- .
10473622	0	tyrosine	40,48	Hck	36,39	tyrosine	Hck	CHEBI:18186	25734(Tax:10116)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	SH2-kinase linker mutations release Hck tyrosine kinase and transforming activities in Rat-2 fibroblasts .
10899899	0	tyrosine	40,48	Hck	56,59	tyrosine	Hck	CHEBI:18186	3055	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|dobj|END_ENTITY	Lipoarabinomannans activate the protein tyrosine kinase Hck in human neutrophils .
11106432	0	tyrosine	51,59	Hck	68,71	tyrosine	Hck	CHEBI:18186	3055	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	Mercuric_chloride activates the Src-family protein tyrosine kinase , Hck in myelomonocytic cells .
12033791	0	tyrosine	28,36	Hck	24,27	tyrosine	Hck	CHEBI:18186	3055	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Interaction with simian Hck tyrosine kinase reveals convergent evolution of the Nef protein from simian and human immunodeficiency viruses despite differential molecular surface usage .
12592324	0	tyrosine	31,39	Hck	67,70	tyrosine	Hck	CHEBI:18186	3055	Chemical	Gene	kinase|compound|START_ENTITY kinase|nmod|END_ENTITY	The interaction of the Bcr-Abl tyrosine kinase with the Src kinase Hck is mediated by multiple binding domains .
14551197	0	tyrosine	48,56	Hck	44,47	tyrosine	Hck	CHEBI:18186	3055	Chemical	Gene	START_ENTITY|nsubj|interaction interaction|nmod|END_ENTITY	Physical and functional interaction between Hck tyrosine kinase and guanine_nucleotide exchange factor C3G results in apoptosis , which is independent of C3G catalytic domain .
15491611	0	tyrosine	111,119	Hck	107,110	tyrosine	Hck	CHEBI:18186	25734(Tax:10116)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Conserved residues in the HIV-1 Nef hydrophobic pocket are essential for recruitment and activation of the Hck tyrosine kinase .
20798061	0	tyrosine	36,44	Hck	32,35	tyrosine	Hck	CHEBI:18186	3055	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Multidomain assembled states of Hck tyrosine kinase in solution .
22021612	0	tyrosine	4,12	Hck	0,3	tyrosine	Hck	CHEBI:18186	3055	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Hck tyrosine kinase regulates TLR4-induced TNF_and_IL-6 production via AP-1 .
7782336	0	tyrosine	107,115	Hck	124,127	tyrosine	Hck	CHEBI:18186	280814(Tax:9913)	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	The Ras GTPase-activating protein -LRB- GAP -RRB- is an SH3 domain-binding protein and substrate for the Src-related tyrosine kinase , Hck .
8350043	0	tyrosine	4,12	Hck	0,3	tyrosine	Hck	CHEBI:18186	15162(Tax:10090)	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Hck tyrosine kinase activity modulates tumor_necrosis_factor production by murine macrophages .
8599760	0	tyrosine	136,144	Hck	132,135	tyrosine	Hck	CHEBI:18186	3055	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	The solution structure of HIV-1 Nef reveals an unexpected fold and permits delineation of the binding surface for the SH3 domain of Hck tyrosine protein kinase .
9343926	0	tyrosine	33,41	Hck	29,32	tyrosine	Hck	CHEBI:18186	3055	Chemical	Gene	START_ENTITY|nsubj|Interaction Interaction|nmod|domain domain|nmod|END_ENTITY	Interaction of SH3 domain of Hck tyrosine kinase with cellular proteins containing proline-rich regions : evidence for modulation by unique domain .
1427910	0	tyrosine	30,38	Hcph	57,61	tyrosine	Hcph	CHEBI:18186	15170(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|gene gene|appos|END_ENTITY	Assignment of a novel protein tyrosine phosphatase gene -LRB- Hcph -RRB- to mouse chromosome 6 .
10206983	0	tyrosine	90,98	HePTP	112,117	tyrosine	HePTP	CHEBI:18186	5778	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|appos|END_ENTITY	Inhibition of T cell signaling by mitogen-activated protein kinase-targeted hematopoietic tyrosine phosphatase -LRB- HePTP -RRB- .
2473389	0	tyrosine	43,51	Heparin-binding_growth_factor_1	0,31	tyrosine	Heparin-binding growth factor 1	CHEBI:18186	14164(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Heparin-binding_growth_factor_1 stimulates tyrosine phosphorylation in NIH 3T3 cells .
21594459	0	tyrosine	33,41	Hepatocyte_growth_factor	0,24	tyrosine	Hepatocyte growth factor	CHEBI:18186	15234(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Hepatocyte_growth_factor induces tyrosine phosphorylation of focal adhesion kinase -LRB- FAK -RRB- and paxillin and enhances cell-matrix interactions .
22052230	0	tyrosine	105,113	Hepatocyte_growth_factor	0,24	tyrosine	Hepatocyte growth factor	CHEBI:18186	3082	Chemical	Gene	expression|acl|START_ENTITY expression|amod|END_ENTITY	Hepatocyte_growth_factor expression in EGFR mutant lung_cancer with intrinsic and acquired resistance to tyrosine kinase inhibitors in a Japanese cohort .
12213470	0	tyrosine	144,152	Her2	139,143	tyrosine	Her2	CHEBI:18186	2064	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Development of a purine-scaffold novel class of Hsp90 binders that inhibit the proliferation of cancer cells and induce the degradation of Her2 tyrosine kinase .
17101784	0	tyrosine	59,67	Hrs	55,58	tyrosine	Hrs	CHEBI:18186	9146	Chemical	Gene	sites|compound|START_ENTITY sites|compound|END_ENTITY	Epidermal_growth_factor_receptor fate is controlled by Hrs tyrosine phosphorylation sites that regulate Hrs degradation .
20159553	0	tyrosine	19,27	Hsp90	47,52	tyrosine	Hsp90	CHEBI:18186	855836(Tax:4932)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Swe1Wee1-dependent tyrosine phosphorylation of Hsp90 regulates distinct facets of chaperone function .
23585225	0	tyrosine	31,39	Hsp90	59,64	tyrosine	Hsp90	CHEBI:18186	104408(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	LPS induces pp60c-src-mediated tyrosine phosphorylation of Hsp90 in lung vascular endothelial cells and mouse lung .
10333047	0	tyrosine	36,44	IA-2	71,75	tyrosine	IA-2	CHEBI:18186	5798	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Glutamate_decarboxylase -LRB- GAD65 -RRB- and tyrosine phosphatase-like protein -LRB- IA-2 -RRB- autoantibodies index in a regional population is related to glucose_intolerance and body mass index .
10936665	0	tyrosine	46,54	IA-2	18,22	tyrosine	IA-2	CHEBI:18186	19275(Tax:10090)	Chemical	Gene	phosphatase|amod|START_ENTITY family|amod|phosphatase Identity|nmod|family Identity|nmod|END_ENTITY	Identity of mouse IA-2 and PTP35 genes of the tyrosine phosphatase family , and their expression in neuroendocrine tissues .
11600216	0	tyrosine	98,106	IA-2	134,138	tyrosine	IA-2	CHEBI:18186	14961(Tax:10090)	Chemical	Gene	molecule|amod|START_ENTITY region|nmod|molecule recognize|nmod|region recognize|xcomp|END_ENTITY	HLA-DQ8 transgenic and NOD mice recognize different epitopes within the cytoplasmic region of the tyrosine phosphatase-like molecule , IA-2 .
12031972	0	tyrosine	35,43	IA-2	70,74	tyrosine	IA-2	CHEBI:18186	19275(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|results results|compound|END_ENTITY	Targeted disruption of the protein tyrosine phosphatase-like molecule IA-2 results in alterations in glucose tolerance tests and insulin secretion .
12697028	0	tyrosine	88,96	IA-2	147,151	tyrosine	IA-2	CHEBI:18186	5798	Chemical	Gene	START_ENTITY|dobj|proteins proteins|amod|islet-cell_antigen_512 islet-cell_antigen_512|dep|END_ENTITY	A novel strategy for the development of selective active-site inhibitors of the protein tyrosine phosphatase-like proteins islet-cell_antigen_512 -LRB- IA-2 -RRB- and phogrin -LRB- IA-2beta -RRB- .
15829408	0	tyrosine	63,71	IA-2	89,93	tyrosine	IA-2	CHEBI:18186	5798	Chemical	Gene	START_ENTITY|dobj|molecule molecule|compound|END_ENTITY	Absence of avidity maturation of autoantibodies to the protein tyrosine phosphatase-like IA-2 molecule and glutamic_acid decarboxylase -LRB- GAD65 -RRB- during progression to type 1 diabetes .
23087044	0	tyrosine	55,63	IA-2	32,36	tyrosine	IA-2	CHEBI:18186	116660(Tax:10116)	Chemical	Gene	family|nmod|START_ENTITY family|compound|END_ENTITY	Immunohistochemical analysis of IA-2 family of protein tyrosine phosphatases in rat gastrointestinal endocrine cells .
23087044	1	tyrosine	229,237	IA-2	146,150	tyrosine	IA-2	CHEBI:18186	116660(Tax:10116)	Chemical	Gene	phosphatases|compound|START_ENTITY phosphatases|nsubj|Islet-associated_protein-2 Islet-associated_protein-2|appos|END_ENTITY	Islet-associated_protein-2 -LRB- IA-2 -RRB- and IA-2b -LRB- also known as phogrin -RRB- are unique neuroendocrine-specific protein tyrosine phosphatases -LRB- PTPs -RRB- .
8024693	0	tyrosine	64,72	IA-2	86,90	tyrosine	IA-2	CHEBI:18186	5798	Chemical	Gene	cloning|nmod|START_ENTITY cloning|amod|END_ENTITY	Molecular cloning and identification of a receptor-type protein tyrosine phosphatase , IA-2 , from human insulinoma .
8665506	0	tyrosine	30,38	IA-2	0,4	tyrosine	IA-2	CHEBI:18186	5798	Chemical	Gene	phosphatase|compound|START_ENTITY END_ENTITY|appos|phosphatase	IA-2 , a transmembrane protein tyrosine phosphatase , is expressed in human lung_cancer cell lines with neuroendocrine phenotype .
8692821	0	tyrosine	45,53	IA-2	0,4	tyrosine	IA-2	CHEBI:18186	5798	Chemical	Gene	family|compound|START_ENTITY protein|nmod|family END_ENTITY|appos|protein	IA-2 , a transmembrane protein of the protein tyrosine phosphatase family , is a major autoantigen in insulin-dependent_diabetes_mellitus .
8805677	0	tyrosine	99,107	IA-2	125,129	tyrosine	IA-2	CHEBI:18186	5798	Chemical	Gene	autoantigen|compound|START_ENTITY autoantigen|compound|END_ENTITY	Autoantibodies in insulin-dependent_diabetes recognize distinct cytoplasmic domains of the protein tyrosine phosphatase-like IA-2 autoantigen .
9725268	0	tyrosine	111,119	IA-2	0,4	tyrosine	IA-2	CHEBI:18186	5798	Chemical	Gene	autoantigens|amod|START_ENTITY autoimmunity|nmod|autoantigens target|nmod|autoimmunity target|nsubj|END_ENTITY	IA-2 -LRB- islet_cell_antigen_512 -RRB- is the primary target of humoral autoimmunity against type 1 diabetes-associated tyrosine phosphatase autoantigens .
7813427	0	tyrosine	13,21	IFNAR	45,50	tyrosine	IFNAR	CHEBI:18186	3454	Chemical	Gene	START_ENTITY|nmod|chain chain|amod|END_ENTITY	Differential tyrosine phosphorylation of the IFNAR chain of the type I interferon receptor and of an associated surface protein in response to IFN-alpha and IFN-beta .
8156998	0	tyrosine	34,42	IFN_gamma	15,24	tyrosine	IFN gamma	CHEBI:18186	3458	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Ligand-induced IFN_gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system -LRB- p91 -RRB- .
23085572	0	tyrosine	36,44	IGF-1	21,26	tyrosine	IGF-1	CHEBI:18186	16000(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Glutamate attenuates IGF-1 receptor tyrosine phosphorylation in mouse brain : possible significance in ischemic brain_damage .
19056263	0	tyrosine	100,108	IGF-1R	84,90	tyrosine	IGF-1R	CHEBI:18186	25718(Tax:10116)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Discovery of 4,6-bis-anilino-1H-pyrrolo -LSB- 2,3-d -RSB- pyrimidines : potent inhibitors of the IGF-1R receptor tyrosine kinase .
19394223	0	tyrosine	133,141	IGF-1R	125,131	tyrosine	IGF-1R	CHEBI:18186	3480	Chemical	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	Discovery of 3,5-disubstituted-1H-pyrrolo -LSB- 2,3-b -RSB- pyridines as potent inhibitors of the insulin-like_growth_factor-1_receptor -LRB- IGF-1R -RRB- tyrosine kinase .
17562544	0	tyrosine	78,86	IGF-1_receptor	63,77	tyrosine	IGF-1 receptor	CHEBI:18186	3480	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Nordihydroguaiaretic_acid -LRB- NDGA -RRB- , an inhibitor of the HER2 and IGF-1_receptor tyrosine kinases , blocks the growth of HER2-overexpressing human breast_cancer cells .
12135605	0	tyrosine	25,33	IGF-I	0,5	tyrosine	IGF-I	CHEBI:18186	3479	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	IGF-I induces caveolin_1 tyrosine phosphorylation and translocation in the lipid rafts .
19508387	0	tyrosine	21,29	IGF-IR	14,20	tyrosine	IGF-IR	CHEBI:18186	3480	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Inhibition of IGF-IR tyrosine kinase induces apoptosis and cell cycle arrest in imatinib-resistant chronic myeloid_leukaemia cells .
19420001	0	tyrosine	100,108	IGF-I_receptor	54,68	tyrosine	IGF-I receptor	CHEBI:18186	3480	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Protein_tyrosine_phosphatase-alpha complexes with the IGF-I_receptor and undergoes IGF-I-stimulated tyrosine phosphorylation that mediates cell migration .
24997432	0	tyrosine	6,14	IGF1R	0,5	tyrosine	IGF1R	CHEBI:18186	3480	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|nummod|END_ENTITY	IGF1R tyrosine kinase inhibitor enhances the cytotoxic effect of methyl_jasmonate in endometrial_cancer .
2546940	1	tyrosine	113,121	IGF_I	83,88	tyrosine	IGF I	CHEBI:18186	24482(Tax:10116)	Chemical	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Mechanism for increased IGF_I - and insulin-stimulated tyrosine kinase activity in fetal muscle .
12645577	0	tyrosine	16,24	IKKbeta	44,51	tyrosine	IKKbeta	CHEBI:18186	3551	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	c-Src-dependent tyrosine phosphorylation of IKKbeta is involved in tumor_necrosis_factor-alpha-induced intercellular_adhesion_molecule-1 expression .
10973911	0	tyrosine	96,104	IL-10	67,72	tyrosine	IL-10	CHEBI:18186	3586	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	A molecular basis for T cell suppression by IL-10 : CD28-associated IL-10 receptor inhibits CD28 tyrosine phosphorylation and phosphatidylinositol 3-kinase binding .
7543512	0	tyrosine	18,26	IL-10	0,5	tyrosine	IL-10	CHEBI:18186	3586	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 and the differential assembly of STAT1 alpha and STAT3 complexes in human T cells and monocytes .
9535722	0	tyrosine	14,22	IL-13	0,5	tyrosine	IL-13	CHEBI:18186	3596	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	IL-13 induces tyrosine phosphorylation of phospholipase_C_gamma-1 following IRS-2 association in human monocytes : relationship with the inhibitory effect of IL-13 on ROI production .
11367516	0	tyrosine	90,98	IL-2	49,53	tyrosine	IL-2	CHEBI:18186	3558	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|END_ENTITY	Differential regulation of CD3 - and CD28-induced IL-2 and IFN-gamma production by a novel tyrosine kinase inhibitor XR774 from Cladosporium cf. cladosporioides .
9618521	7	tyrosine	1193,1201	IL-2	1173,1177	tyrosine	CD18	CHEBI:18186	3689	Chemical	Gene	phosphorylation|compound|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Thus , IL-2 induces strong tyrosine phosphorylation of fakB in beta2-integrin-positive but not in beta2-integrin-negative T cells , and CD18 mAb selectively blocks IL-2-induced fakB-tyrosine phosphorylation in beta2-integrin-positive T cells .
8390454	0	tyrosine	37,45	IL-4_receptor	69,82	tyrosine	IL-4 receptor	CHEBI:18186	16190(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Interleukin-4 -LRB- IL-4 -RRB- induces protein tyrosine phosphorylation of the IL-4_receptor and association of phosphatidylinositol 3-kinase to the IL-4_receptor in a mouse T cell line , HT2 .
8543824	0	tyrosine	80,88	IL-5	0,4	tyrosine	IL-5	CHEBI:18186	3567	Chemical	Gene	activates|ccomp|START_ENTITY activates|nsubj|END_ENTITY	IL-5 activates a 45-kilodalton mitogen-activated protein -LRB- MAP -RRB- kinase and Jak-2 tyrosine kinase in human eosinophils .
14636898	0	tyrosine	13,21	IL-7	0,4	tyrosine	IL-7	CHEBI:18186	25647(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	IL-7 induces tyrosine phosphorylation of clathrin_heavy_chain .
20144186	0	tyrosine	59,67	IL-7Ralpha	80,90	tyrosine	IL-7Ralpha	CHEBI:18186	3575	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Site-directed mutagenesis reveals a unique requirement for tyrosine residues in IL-7Ralpha and TSLPR cytoplasmic domains in TSLP-dependent cell proliferation .
8756628	0	tyrosine	9,17	IL-9	137,141	tyrosine	IL-9	CHEBI:18186	16198(Tax:10090)	Chemical	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	A single tyrosine of the interleukin-9 -LRB- IL-9 -RRB- _ receptor is required for STAT activation , antiapoptotic activity , and growth regulation by IL-9 .
21446886	5	tyrosine	887,895	IR	924,926	tyrosine	IR	CHEBI:18186	3643	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Currently , both IGF-1R-neutralizing antibodies and small-molecule tyrosine kinase inhibitors of IGF-1R / IR are in clinical development .
26063811	4	tyrosine	793,801	IR	825,827	tyrosine	IR	D014443	3643	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	The co-expression of R3 RPTPs with the IR in HEK293T cells suppressed insulin-induced tyrosine phosphorylation of the IR .
10583412	0	tyrosine	169,177	IRS-1	163,168	tyrosine	IRS-1	CHEBI:18186	3667	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Insulin-like_growth_factor-I -LRB- IGF-I -RRB- - dependent activation of pp42/44 mitogen-activated_protein kinase occurs independently of IGF-I_receptor kinase activation and IRS-1 tyrosine phosphorylation .
11471071	0	tyrosine	6,14	IRS-1	0,5	tyrosine	IRS-1	CHEBI:18186	3667	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	IRS-1 tyrosine phosphorylation reflects insulin-induced metabolic and mitogenic responses in 3T3-L1 pre-adipocytes .
12173038	0	tyrosine	125,133	IRS-1	119,124	tyrosine	IRS-1	CHEBI:18186	16367(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	ETV6-NTRK3 transformation requires insulin-like growth factor 1 receptor signaling and is associated with constitutive IRS-1 tyrosine phosphorylation .
12207909	0	tyrosine	31,39	IRS-1	59,64	tyrosine	IRS-1	CHEBI:18186	3667	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Proteasome inhibitors regulate tyrosine phosphorylation of IRS-1 and insulin signaling in adipocytes .
12800089	3	tyrosine	645,653	IRS-1	639,644	tyrosine	IRS-1	CHEBI:18186	3667	Chemical	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	L6 skeletal muscle cells -LRB- L6 cells -RRB- were treated with inhibitors of protein-tyrosine phosphatases , proteasomal degradation , and mammalian_target_of_rapamycin -LRB- mTOR -RRB- , and the effects of insulin on glucose uptake , IRS-1 tyrosine phosphorylation , phosphatidylinositol -LRB- PI -RRB- 3-kinase activity , and IRS-1 mass were examined .
15069075	0	tyrosine	157,165	IRS-1	185,190	tyrosine	IRS-1	CHEBI:18186	3667	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Protein_kinase_C-zeta-induced phosphorylation of Ser318 in insulin_receptor_substrate-1 -LRB- IRS-1 -RRB- attenuates the interaction with the insulin_receptor and the tyrosine phosphorylation of IRS-1 .
15140184	8	tyrosine	1194,1202	IRS-1	1252,1257	tyrosine	IGF-1	CHEBI:18186	3479	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Moreover , IGF-1 potently induced the tyrosine phosphorylation of insulin_receptor_substrate-1 -LRB- IRS-1 -RRB- and its association with PI3 kinase while BDNF was weak in these assays .
17001108	0	tyrosine	68,76	IRS-1	62,67	tyrosine	IRS-1	D014443	3667	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Estrogen_receptor_alpha regulates insulin sensitivity through IRS-1 tyrosine phosphorylation in mature 3T3-L1 adipocytes .
17942003	0	tyrosine	119,127	IRS-1	113,118	tyrosine	IRS-1	CHEBI:18186	25467(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Bitter gourd -LRB- Momordica charantia -RRB- improves insulin sensitivity by increasing skeletal muscle insulin-stimulated IRS-1 tyrosine phosphorylation in high-fat-fed rats .
21168390	7	tyrosine	990,998	IRS-1	1018,1023	tyrosine	IRS-2	CHEBI:18186	8660	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Results of the in vitro tyrosine phosphorylation assay indicated that tyrosine phosphorylation of IRS-1 by insulin_receptor was decreased when IRS-1 was contained in IRSomes prepared from 3T3-L1 adipocytes treated with TNF-a .
27090933	0	tyrosine	131,139	IRS-1	125,130	tyrosine	IRS-1	D014443	16367(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Ursolic_acid and rosiglitazone combination improves insulin sensitivity by increasing the skeletal muscle insulin-stimulated IRS-1 tyrosine phosphorylation in high-fat diet-fed C57BL/6J mice .
7559552	1	tyrosine	150,158	IRS-1	178,183	tyrosine	IRS-1	CHEBI:18186	3667	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Possible mechanism for suppression of insulin-stimulated tyrosine phosphorylation of IRS-1 .
7593251	0	tyrosine	91,99	IRS-1	119,124	tyrosine	IRS-1	CHEBI:18186	3667	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Combination of insulinomimetic agents H2O2 and vanadate enhances insulin_receptor mediated tyrosine phosphorylation of IRS-1 leading to IRS-1 association with the phosphatidylinositol 3-kinase .
7683695	0	tyrosine	66,74	IRS-1	60,65	tyrosine	IRS-1	CHEBI:18186	25467(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|END_ENTITY	Glucocorticoid regulation of insulin_receptor and substrate IRS-1 tyrosine phosphorylation in rat skeletal muscle in vivo .
8660383	0	tyrosine	46,54	IRS-1	74,79	tyrosine	IRS-1	CHEBI:18186	3667	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Differential regulation of insulin-stimulated tyrosine phosphorylation of IRS-1 and SHC by Wortmannin in intact cells .
11604226	0	tyrosine	20,28	IRS-2	14,19	tyrosine	IRS-2	CHEBI:18186	29376(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of IRS-2 tyrosine phosphorylation in fasting and diabetes .
24814346	0	tyrosine	18,26	IRS1	43,47	tyrosine	IRS1	D014443	3667	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|nmod|END_ENTITY	PTEN is a protein tyrosine phosphatase for IRS1 .
14978080	4	tyrosine	755,763	IRS2	783,787	tyrosine	IL-4	CHEBI:18186	16189(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	IL-4-induced tyrosine phosphorylation of IRS2 was elevated in Tg -LRB- + -RRB- B cells , whereas IL-4-induced phosphorylation of STAT6 was similar between Tg -LRB- + -RRB- and Tg -LRB- - -RRB- B cells .
26581914	0	tyrosine	12,20	ITK	29,32	tyrosine	ITK	D014443	16428(Tax:10090)	Chemical	Gene	START_ENTITY|ccomp|regulate regulate|nsubj|END_ENTITY	Nonreceptor tyrosine kinases ITK and BTK negatively regulate mast cell proinflammatory responses to lipopolysaccharide .
11076697	0	tyrosine	57,65	I_kappa_B-alpha	85,100	tyrosine	I kappa B-alpha	CHEBI:18186	4792	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Silica induces nuclear factor-kappa B activation through tyrosine phosphorylation of I_kappa_B-alpha in RAW264 .7 macrophages .
12711606	0	tyrosine	47,55	I_kappa_B_alpha	75,90	tyrosine	I kappa B alpha	CHEBI:18186	4792	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Hydrogen_peroxide activates NF-kappa_B through tyrosine phosphorylation of I_kappa_B_alpha and serine phosphorylation of p65 : evidence for the involvement of I_kappa_B_alpha kinase and Syk protein-tyrosine kinase .
8137243	0	tyrosine	106,114	I_kappa_B_alpha	87,102	tyrosine	I kappa B alpha	CHEBI:18186	4792	Chemical	Gene	residues|amod|START_ENTITY END_ENTITY|nmod|residues	Hypoxia causes the activation of nuclear_factor_kappa_B through the phosphorylation of I_kappa_B_alpha on tyrosine residues .
12960335	0	tyrosine	46,54	Ig_alpha	74,82	tyrosine	Ig alpha	CHEBI:18186	12518(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Immunoglobulin mu heavy chains do not mediate tyrosine phosphorylation of Ig_alpha from the ER-cis-Golgi .
16818674	0	tyrosine	8,16	Ig_beta	0,7	tyrosine	Ig beta	CHEBI:18186	15985(Tax:10090)	Chemical	Gene	residues|compound|START_ENTITY residues|compound|END_ENTITY	Ig_beta tyrosine residues contribute to the control of B cell receptor signaling by regulating receptor internalization .
26473948	0	tyrosine	124,132	IkBa	155,159	tyrosine	IkBa	D014443	4792	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Epidermal growth factor -LRB- EGF -RRB- activates nuclear factor-kB through IkBa kinase-independent but EGF receptor-kinase dependent tyrosine 42 phosphorylation of IkBa .
16431847	0	tyrosine	85,93	IkappaB-alpha	113,126	tyrosine	IkappaB-alpha	CHEBI:18186	18035(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Src tyrosine kinases mediate crystalline silica-induced NF-kappaB activation through tyrosine phosphorylation of IkappaB-alpha and p65_NF-kappaB in RAW 264.7 macrophages .
10722693	0	tyrosine	62,70	IkappaBalpha	106,118	tyrosine	IkappaBalpha	CHEBI:18186	4792	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Pervanadate-induced nuclear factor-kappaB activation requires tyrosine phosphorylation and degradation of IkappaBalpha .
11266466	0	tyrosine	103,111	IkappaBalpha	131,143	tyrosine	IkappaBalpha	CHEBI:18186	25493(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Activation of nuclear factor kappaB and Bcl-x survival gene expression by nerve growth factor requires tyrosine phosphorylation of IkappaBalpha .
12909638	0	tyrosine	70,78	IkappaBalpha	98,110	tyrosine	IkappaBalpha	CHEBI:18186	4792	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Hepatitis_C virus NS5A and subgenomic replicon activate NF-kappaB via tyrosine phosphorylation of IkappaBalpha and its degradation by calpain protease .
16132703	0	tyrosine	21,29	IkappaBalpha	49,61	tyrosine	IkappaBalpha	CHEBI:18186	4792	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Okadaic_acid induces tyrosine phosphorylation of IkappaBalpha that mediated by PKR pathway in human osteoblastic MG63 cells .
17533369	0	tyrosine	136,144	IkappaBalpha	167,179	tyrosine	IkappaBalpha	CHEBI:18186	4792	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Epidermal growth factor -LRB- EGF -RRB- activates nuclear factor-kappaB through IkappaBalpha kinase-independent but EGF_receptor-kinase dependent tyrosine 42 phosphorylation of IkappaBalpha .
18353872	0	tyrosine	53,61	IkappaBalpha	81,93	tyrosine	IkappaBalpha	CHEBI:18186	4792	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	High glucose-induced NF-kappaB activation occurs via tyrosine phosphorylation of IkappaBalpha in human glomerular endothelial cells : involvement of Syk tyrosine kinase .
8940099	0	tyrosine	14,22	IkappaBalpha	42,54	tyrosine	IkappaBalpha	CHEBI:18186	4792	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Site-specific tyrosine phosphorylation of IkappaBalpha negatively regulates its inducible phosphorylation and degradation .
19366662	0	tyrosine	17,25	Insulin	0,7	tyrosine	Insulin	CHEBI:18186	3630	Chemical	Gene	START_ENTITY|nsubj|receptor receptor|compound|END_ENTITY	Insulin receptor tyrosine kinase substrate links the E. _ coli O157 : H7 actin assembly effectors Tir and EspF -LRB- U -RRB- during pedestal formation .
2002058	0	tyrosine	66,74	Insulin	0,7	tyrosine	Insulin	CHEBI:18186	3630	Chemical	Gene	domain|amod|START_ENTITY mutations|nmod|domain due|nmod|mutations resistance|amod|due resistance|compound|END_ENTITY	Insulin resistance and diabetes due to different mutations in the tyrosine kinase domain of both insulin_receptor gene alleles .
2174434	0	tyrosine	17,25	Insulin	0,7	tyrosine	Insulin	CHEBI:18186	3630	Chemical	Gene	START_ENTITY|nsubj|receptor receptor|compound|END_ENTITY	Insulin receptor tyrosine kinase-catalyzed phosphorylation of 422 -LRB- aP2 -RRB- protein .
2250023	0	tyrosine	17,25	Insulin	0,7	tyrosine	Insulin	CHEBI:18186	3630	Chemical	Gene	START_ENTITY|nsubj|receptor receptor|compound|END_ENTITY	Insulin receptor tyrosine residues 1162 and 1163 control insulin stimulation of myristoyl-diacylglycerol generation and subsequent activation of glucose transport .
25259572	0	tyrosine	110,118	Insulin	0,7	tyrosine	Insulin	CHEBI:18186	3630	Chemical	Gene	domain|compound|START_ENTITY alteration|nmod|domain coincides|nmod|alteration coincides|nsubj|resistance resistance|compound|END_ENTITY	Insulin resistance induced by hyperinsulinemia coincides with a persistent alteration at the insulin_receptor tyrosine kinase domain .
6149850	0	tyrosine	22,30	Insulin	0,7	tyrosine	Insulin	CHEBI:18186	396145(Tax:9031)	Chemical	Gene	induction|amod|START_ENTITY inhibition|nmod|induction inhibition|compound|END_ENTITY	Insulin inhibition of tyrosine aminotransferase induction by dexamethasone is species-related .
7540611	0	tyrosine	23,31	Insulin	0,7	tyrosine	Insulin	CHEBI:18186	3630	Chemical	Gene	phosphorylation|amod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Insulin stimulates the tyrosine phosphorylation of caveolin .
8878559	0	tyrosine	63,71	Insulin	0,7	tyrosine	Insulin	CHEBI:18186	3630	Chemical	Gene	domain|compound|START_ENTITY absence|nmod|domain internalization|nmod|absence internalization|compound|END_ENTITY	Insulin internalization in the absence of the insulin_receptor tyrosine kinase domain is insufficient for mediating intracellular biological effects .
9585382	0	tyrosine	16,24	Insulin	0,7	tyrosine	Insulin	CHEBI:18186	3630	Chemical	Gene	dephosphorylation|amod|START_ENTITY induces|dobj|dephosphorylation induces|nsubj|END_ENTITY	Insulin induces tyrosine dephosphorylation of a 92 kDA protein in suspended monocytes .
9692679	4	tyrosine	1013,1021	Insulin	990,997	tyrosine	Insulin	CHEBI:18186	3630	Chemical	Gene	phosphorylation|amod|START_ENTITY increased|dobj|phosphorylation increased|nsubj|END_ENTITY	Insulin also increased tyrosine phosphorylation of both a 72-kDa protein and the 46-kDa Shc isoform only in the caveolin-enriched fraction .
8605967	0	tyrosine	43,51	Insulin-like_growth_factor-1	0,28	tyrosine	Insulin-like growth factor-1	CHEBI:18186	16000(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Insulin-like_growth_factor-1 induces rapid tyrosine phosphorylation of the vav proto-oncogene product .
18566219	0	tyrosine	61,69	Insulin-like_growth_factor-I_receptor	0,37	tyrosine	Insulin-like growth factor-I receptor	CHEBI:18186	3480	Chemical	Gene	blockade|nmod|START_ENTITY blockade|amod|END_ENTITY	Insulin-like_growth_factor-I_receptor blockade by a specific tyrosine kinase inhibitor for human gastrointestinal_carcinomas .
19638450	0	tyrosine	38,46	Insulin-like_growth_factor-I_receptor	0,37	tyrosine	Insulin-like growth factor-I receptor	CHEBI:18186	3480	Chemical	Gene	kinase|amod|START_ENTITY cyclolignan_picropodophyllin|amod|kinase cyclolignan_picropodophyllin|amod|END_ENTITY	Insulin-like_growth_factor-I_receptor tyrosine kinase inhibitor cyclolignan_picropodophyllin inhibits proliferation and induces apoptosis in multidrug resistant osteosarcoma cell lines .
1718586	0	tyrosine	45,53	Insulin-like_growth_factor_I	0,28	tyrosine	Insulin-like growth factor I	CHEBI:18186	16000(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Insulin-like_growth_factor_I rapidly induces tyrosine phosphorylation of a Mr 150,000 and a Mr 160,000 protein in highly metastatic mouse colon_carcinoma 26 NL-17 cells .
3292678	0	tyrosine	17,25	Insulin_receptor	0,16	tyrosine	Insulin receptor	CHEBI:18186	3643	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Insulin_receptor tyrosine kinase activity is abnormal in circulating cells and cultured fibroblasts but normal in transformed lymphocytes from a type A insulin-resistant patient .
3892304	0	tyrosine	17,25	Insulin_receptor	0,16	tyrosine	Insulin receptor	CHEBI:18186	16337(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Insulin_receptor tyrosine kinase is defective in skeletal muscle of insulin-resistant obese mice .
8270131	0	tyrosine	17,25	Insulin_receptor	0,16	tyrosine	Insulin receptor	CHEBI:18186	3643	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Insulin_receptor tyrosine kinase activity is reduced in monocytes from non-obese normoglycaemic insulin-resistant subjects .
7514165	0	tyrosine	25,33	Interferon-gamma	0,16	tyrosine	Interferon-gamma	CHEBI:18186	3458	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Interferon-gamma induces tyrosine phosphorylation of interferon-gamma receptor and regulated association of protein tyrosine kinases , Jak1 and Jak2 , with its receptor .
1376256	0	tyrosine	30,38	Interleukin-1	0,13	tyrosine	Interleukin-1	CHEBI:18186	3552	Chemical	Gene	phosphorylation|compound|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Interleukin-1 induces protein tyrosine phosphorylation in T cells .
9367850	0	tyrosine	32,40	Interleukin-1	0,13	tyrosine	Interleukin-1	CHEBI:18186	3552	Chemical	Gene	activity|compound|START_ENTITY modulates|dobj|activity modulates|nsubj|END_ENTITY	Interleukin-1 modulates protein tyrosine phosphatase activity and permeability of brain endothelial cells .
7486676	0	tyrosine	23,31	Interleukin-11	0,14	tyrosine	Interleukin-11	CHEBI:18186	3589	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Interleukin-11 induces tyrosine phosphorylation , and c-jun and c-fos mRNA expression in human K562 and U937 cells .
7529495	0	tyrosine	29,37	Interleukin-13	0,14	tyrosine	Interleukin-13	CHEBI:18186	3596	Chemical	Gene	phosphorylation|compound|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Interleukin-13 induces rapid tyrosine phosphorylation and activation of Raf-1 kinase in human monocytic progenitor cell line U937 .
10882748	0	tyrosine	29,37	Interleukin-15	0,14	tyrosine	Interleukin-15	CHEBI:18186	16168(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Interleukin-15 induces rapid tyrosine phosphorylation of STAT6 and the expression of interleukin-4 in mouse mast cells .
7528668	0	tyrosine	22,30	Interleukin-2	0,13	tyrosine	Interleukin-2	CHEBI:18186	3558	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Interleukin-2 induces tyrosine phosphorylation and nuclear translocation of stat3 in human T lymphocytes .
7690544	0	tyrosine	22,30	Interleukin-2	0,13	tyrosine	Interleukin-2	CHEBI:18186	3558	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Interleukin-2 induces tyrosine phosphorylation of the vav proto-oncogene product in human T cells : lack of requirement for the tyrosine kinase lck .
9129156	0	tyrosine	22,30	Interleukin-2	0,13	tyrosine	Interleukin-2	CHEBI:18186	3558	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Interleukin-2 induces tyrosine phosphorylation of SHP-2 through IL-2_receptor beta chain .
2681215	0	tyrosine	29,37	Interleukin-3	0,13	tyrosine	Interleukin-3	CHEBI:18186	16187(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Interleukin-3 stimulates the tyrosine phosphorylation of the 140-kilodalton interleukin-3 receptor .
8390454	0	tyrosine	37,45	Interleukin-4	0,13	tyrosine	Interleukin-4	CHEBI:18186	16189(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Interleukin-4 -LRB- IL-4 -RRB- induces protein tyrosine phosphorylation of the IL-4_receptor and association of phosphatidylinositol 3-kinase to the IL-4_receptor in a mouse T cell line , HT2 .
20687222	0	tyrosine	20,28	Interleukin-6	50,63	tyrosine	Interleukin-6	CHEBI:18186	3569	Chemical	Gene	START_ENTITY|nmod|regulation regulation|compound|END_ENTITY	Role of the protein tyrosine phosphatase SHP-1 in Interleukin-6 regulation of prostate_cancer cells .
8617307	0	tyrosine	22,30	Interleukin-6	0,13	tyrosine	Interleukin-6	CHEBI:18186	3569	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Interleukin-6 induces tyrosine phosphorylation of the Ras activating protein Shc , and its complex formation with Grb2 in the human multiple myeloma cell line LP-1 .
7544789	0	tyrosine	22,30	Interleukin-9	0,13	tyrosine	Interleukin-9	CHEBI:18186	16198(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Interleukin-9 induces tyrosine phosphorylation of insulin_receptor_substrate-1 via JAK tyrosine kinases .
1996324	0	tyrosine	22,30	Interleukin_2	0,13	tyrosine	Interleukin 2	CHEBI:18186	16183(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Interleukin_2 induces tyrosine phosphorylation and activation of p72-74 Raf-1 kinase in a T-cell line .
2583191	0	tyrosine	25,33	Interleukin_2	0,13	tyrosine	Interleukin 2	CHEBI:18186	3558	Chemical	Gene	phosphorylation|amod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Interleukin_2 stimulates tyrosine phosphorylation in T cell membrane fractions .
3261586	0	tyrosine	29,37	Interleukin_3	0,13	tyrosine	Interleukin 3	CHEBI:18186	16187(Tax:10090)	Chemical	Gene	stimulation|nmod|START_ENTITY stimulation|amod|END_ENTITY	Interleukin_3 stimulation of tyrosine kinase activity in FDC-P1 cells .
9071559	0	tyrosine	27,35	Interleukin_6	0,13	tyrosine	Interleukin 6	CHEBI:18186	16193(Tax:10090)	Chemical	Gene	activity|amod|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	Interleukin_6 stimulates a tyrosine kinase activity potentially involved in mouse hybridoma cell growth .
11250890	0	tyrosine	36,44	Itk	52,55	tyrosine	Itk	CHEBI:18186	3702	Chemical	Gene	function|nmod|START_ENTITY kinase|nsubj|function kinase|dobj|END_ENTITY	A novel function for the Tec family tyrosine kinase Itk in activation of beta_1 integrins by the T-cell receptor .
11437596	0	tyrosine	24,32	Itk	20,23	tyrosine	Itk	CHEBI:18186	3702	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Characterization of Itk tyrosine kinase : contribution of noncatalytic domains to enzymatic activity .
11830645	0	tyrosine	18,26	Itk	34,37	tyrosine	Itk	CHEBI:18186	3702	Chemical	Gene	Regulation|nmod|START_ENTITY kinase|nsubj|Regulation kinase|dobj|END_ENTITY	Regulation of the tyrosine kinase Itk by the peptidyl-prolyl isomerase cyclophilin_A .
23935099	0	tyrosine	75,83	Itk	92,95	tyrosine	Itk	CHEBI:18186	3702	Chemical	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	Discovery of novel irreversible inhibitors of interleukin -LRB- IL -RRB- -2 - inducible tyrosine kinase -LRB- Itk -RRB- by targeting cysteine 442 in the ATP pocket .
9130632	0	tyrosine	23,31	Itk	0,3	tyrosine	Itk	CHEBI:18186	3702	Chemical	Gene	kinase|compound|START_ENTITY END_ENTITY|appos|kinase	Itk , a T cell-specific tyrosine kinase , is required for CD2-mediated interleukin-2 promoter activation in the human T cell line Jurkat .
10929036	2	tyrosine	435,443	JAK1	458,462	tyrosine	JAK2	CHEBI:18186	3717	Chemical	Gene	kinases|nsubj|START_ENTITY kinases|dobj|END_ENTITY	The signal transduction of gp130 involves the Janus tyrosine kinases -LRB- JAK -RRB- JAK1 , JAK2 and Tyk2 and then the downstream effectors comprising the signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- and mitogen-activated protein kinase -LRB- MAPK -RRB- pathways .
7525556	0	tyrosine	13,21	JAK1	41,45	tyrosine	JAK1	CHEBI:18186	3716	Chemical	Gene	START_ENTITY|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Differential tyrosine phosphorylation of JAK1 , JAK2 , and STAT1 by growth_hormone and interferon-gamma in IM-9 cells .
8041779	0	tyrosine	38,46	JAK1	24,28	tyrosine	JAK1	CHEBI:18186	3716	Chemical	Gene	START_ENTITY|nsubj|association association|nmod|END_ENTITY	Physical association of JAK1 and JAK2 tyrosine kinases with the interleukin_2 receptor beta and gamma chains .
10912517	0	tyrosine	12,20	JAK2	28,32	tyrosine	JAK2	CHEBI:18186	3717	Chemical	Gene	Role|nmod|START_ENTITY kinase|nsubj|Role kinase|dobj|END_ENTITY	Role of the tyrosine kinase JAK2 in signal transduction by growth_hormone .
15860661	0	tyrosine	26,34	JAK2	4,8	tyrosine	JAK2	CHEBI:18186	3717	Chemical	Gene	mutation|compound|START_ENTITY mutation|compound|END_ENTITY	The JAK2 V617F activating tyrosine kinase mutation is an infrequent event in both `` atypical '' myeloproliferative_disorders and myelodysplastic_syndromes .
1620548	0	tyrosine	50,58	JAK2	0,4	tyrosine	JAK2	CHEBI:18186	3717	Chemical	Gene	kinases|compound|START_ENTITY family|nmod|kinases member|nmod|family END_ENTITY|appos|member	JAK2 , a third member of the JAK family of protein tyrosine kinases .
16330446	0	tyrosine	60,68	JAK2	55,59	tyrosine	JAK2	CHEBI:18186	3717	Chemical	Gene	mutation|compound|START_ENTITY mutation|compound|END_ENTITY	Chronic_neutrophilic_leukemia with an associated V617F JAK2 tyrosine kinase mutation .
16420986	0	tyrosine	27,35	JAK2	22,26	tyrosine	JAK2	CHEBI:18186	3717	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	-LSB- Acquired mutation of JAK2 tyrosine kinase and polycythaemia vera -RSB- .
16762626	0	tyrosine	34,42	JAK2	29,33	tyrosine	JAK2	CHEBI:18186	3717	Chemical	Gene	START_ENTITY|nsubj|Prevalence Prevalence|nmod|END_ENTITY	Prevalence of the activating JAK2 tyrosine kinase mutation V617F in the Budd-Chiari_syndrome .
17230231	0	tyrosine	51,59	JAK2	46,50	tyrosine	JAK2	CHEBI:18186	3717	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Epigenetic alterations complement mutation of JAK2 tyrosine kinase in patients with BCR/ABL-negative myeloproliferative_disorders .
20331577	0	tyrosine	38,46	JAK2	33,37	tyrosine	JAK2	CHEBI:18186	3717	Chemical	Gene	START_ENTITY|nsubj|prevalence prevalence|nmod|END_ENTITY	The prevalence of the activating JAK2 tyrosine kinase mutation in chronic porto-splenomesenteric venous_thrombosis .
23891636	0	tyrosine	107,115	JAK2	102,106	tyrosine	JAK2	CHEBI:18186	3717	Chemical	Gene	kinase|amod|START_ENTITY kinase|nummod|END_ENTITY	Analysis of steady-state F rster resonance energy transfer data by avoiding pitfalls : interaction of JAK2 tyrosine kinase with N-methylanthraniloyl_nucleotides .
26413812	0	tyrosine	5,13	JAK2	0,4	tyrosine	JAK2	D014443	3717	Chemical	Gene	kinase|amod|START_ENTITY kinase|nummod|END_ENTITY	JAK2 tyrosine kinase mediates integrin activation induced by CXCL12 in B-cell_chronic_lymphocytic_leukemia .
7515493	0	tyrosine	19,27	JAK2	14,18	tyrosine	JAK2	CHEBI:18186	3717	Chemical	Gene	START_ENTITY|nsubj|Activation Activation|nmod|END_ENTITY	Activation of JAK2 tyrosine kinase by prolactin receptors in Nb2 cells and mouse mammary gland explants .
7528775	0	tyrosine	31,39	JAK2	59,63	tyrosine	JAK2	CHEBI:18186	3717	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Interleukin 12 -LRB- IL-12 -RRB- induces tyrosine phosphorylation of JAK2 and TYK2 : differential use of Janus family tyrosine kinases by IL-2 and IL-12 .
7540178	0	tyrosine	20,28	JAK2	15,19	tyrosine	JAK2	CHEBI:18186	100358134(Tax:9986)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Regions of the JAK2 tyrosine kinase required for coupling to the growth_hormone receptor .
7543416	0	tyrosine	58,66	JAK2	44,48	tyrosine	JAK2	CHEBI:18186	3717	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	The thrombopoietin receptor c-MPL activates JAK2 and TYK2 tyrosine kinases .
7579336	0	tyrosine	88,96	JAK2	140,144	tyrosine	JAK2	CHEBI:18186	3717	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Distinct regions of the granulocyte_colony-stimulating_factor receptor are required for tyrosine phosphorylation of the signaling molecules JAK2 , Stat3 , and p42 , p44MAPK .
7888666	0	tyrosine	59,67	JAK2	54,58	tyrosine	JAK2	CHEBI:18186	3717	Chemical	Gene	kinase|amod|START_ENTITY kinase|nummod|END_ENTITY	Interleukin-5 signaling in human eosinophils involves JAK2 tyrosine kinase and Stat1 alpha .
7956946	0	tyrosine	76,84	JAK2	71,75	tyrosine	JAK2	CHEBI:18186	3717	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Interaction of the growth hormone receptor cytoplasmic domain with the JAK2 tyrosine kinase .
8063815	0	tyrosine	87,95	JAK2	82,86	tyrosine	JAK2	CHEBI:18186	3717	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Domains of the growth_hormone_receptor required for association and activation of JAK2 tyrosine kinase .
8068943	0	tyrosine	55,63	JAK2	42,46	tyrosine	JAK2	CHEBI:18186	3717	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Erythropoietin induces association of the JAK2 protein tyrosine kinase with the erythropoietin receptor in vivo .
8530527	0	tyrosine	124,132	JAK2	119,123	tyrosine	JAK2	CHEBI:18186	3717	Chemical	Gene	kinase|amod|START_ENTITY kinase|nummod|END_ENTITY	Receptors for interleukin _ -LRB- IL -RRB- -4 do not associate with the common gamma chain , and IL-4 induces the phosphorylation of JAK2 tyrosine kinase in human colon_carcinoma cells .
8698849	0	tyrosine	33,41	JAK2	28,32	tyrosine	JAK2	CHEBI:18186	3717	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	IL-4 and IL-13 activate the JAK2 tyrosine kinase and Stat6 in cultured human vascular endothelial cells through a common pathway that does not involve the gamma_c chain .
8703019	0	tyrosine	16,24	JAK2	44,48	tyrosine	JAK2	CHEBI:18186	24514(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Insulin induces tyrosine phosphorylation of JAK2 in insulin-sensitive tissues of the intact rat .
8770909	0	tyrosine	26,34	JAK2	54,58	tyrosine	JAK2	CHEBI:18186	24514(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Growth_hormone stimulates tyrosine phosphorylation of JAK2 and STAT5 , but not insulin_receptor_substrate-1 or SHC proteins in liver and skeletal muscle of normal rats in vivo .
9211920	0	tyrosine	117,125	JAK2	112,116	tyrosine	JAK2	CHEBI:18186	24514(Tax:10116)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Interaction of growth_hormone-activated STATs with SH2-containing phosphotyrosine phosphatase SHP-1 and nuclear JAK2 tyrosine kinase .
9516124	7	tyrosine	1051,1059	JAK2	1079,1083	tyrosine	JAK1	CHEBI:18186	3716	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	IL-5 stimulation resulted in tyrosine phosphorylation of JAK2 , JAK1 , betac , and STAT5 .
9553131	0	tyrosine	30,38	JAK2	112,116	tyrosine	JAK2	CHEBI:18186	16452(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nmod|END_ENTITY	Growth_hormone stimulates the tyrosine phosphorylation and association of p125 focal_adhesion_kinase -LRB- FAK -RRB- with JAK2 .
9814969	0	tyrosine	42,50	JAK2	37,41	tyrosine	JAK2	CHEBI:18186	3717	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Regulation of angiotensin_II-induced JAK2 tyrosine phosphorylation : roles of SHP-1 and SHP-2 .
9886807	0	tyrosine	30,38	JAK2	58,62	tyrosine	JAK2	CHEBI:18186	24514(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Growth_hormone stimulates the tyrosine kinase activity of JAK2 and induces tyrosine phosphorylation of insulin_receptor substrates and Shc in rat tissues .
16515530	0	tyrosine	23,31	JAK3	10,14	tyrosine	JAK3	CHEBI:18186	3718	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Targeting JAK3 and BTK tyrosine kinases with rationally-designed inhibitors .
7662955	0	tyrosine	13,21	JAK3	0,4	tyrosine	JAK3	CHEBI:18186	3718	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	JAK3 protein tyrosine kinase mediates interleukin-7-induced activation of phosphatidylinositol-3 ' kinase .
8143863	0	tyrosine	75,83	JAK3	25,29	tyrosine	JAK3	CHEBI:18186	25326(Tax:10116)	Chemical	Gene	family|nmod|START_ENTITY member|nmod|family END_ENTITY|appos|member	Molecular cloning of rat JAK3 , a novel member of the JAK family of protein tyrosine kinases .
9391116	0	tyrosine	9,17	JAK3	43,47	tyrosine	JAK3	CHEBI:18186	3718	Chemical	Gene	sites|amod|START_ENTITY sites|nmod|END_ENTITY	Distinct tyrosine phosphorylation sites in JAK3 kinase domain positively and negatively regulate its enzymatic activity .
9469413	0	tyrosine	29,37	JAK3	14,18	tyrosine	JAK3	CHEBI:18186	3718	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Inhibition of JAK3 and STAT6 tyrosine phosphorylation by the immunosuppressive drug leflunomide leads to a block in IgG1 production .
8770944	0	tyrosine	58,66	JAK_1	44,49	tyrosine	JAK 1	CHEBI:18186	3716	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	PDGF stimulates tyrosine phosphorylation of JAK_1 protein tyrosine kinase in human mesangial cells .
18486448	0	tyrosine	52,60	JIP1	47,51	tyrosine	JIP1	CHEBI:18186	9479	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|compound|END_ENTITY	The docking properties of SHIP2 influence both JIP1 tyrosine phosphorylation and JNK activity .
9200453	0	tyrosine	31,39	Jak-1	74,79	tyrosine	Jak-1	CHEBI:18186	3716	Chemical	Gene	START_ENTITY|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	TGF-beta inhibits IL-2-induced tyrosine phosphorylation and activation of Jak-1 and Stat_5 in T lymphocytes .
10198225	0	tyrosine	77,85	Jak2	72,76	tyrosine	Jak2	CHEBI:18186	3717	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Physical interaction between interleukin-12 receptor beta 2 subunit and Jak2 tyrosine kinase : Jak2 associates with cytoplasmic membrane-proximal region of interleukin-12 receptor beta 2 via amino-terminus .
10925297	0	tyrosine	74,82	Jak2	102,106	tyrosine	Jak2	CHEBI:18186	3717	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Regulation of neutrophil adhesion by pituitary growth hormone accompanies tyrosine phosphorylation of Jak2 , p125FAK , and paxillin .
11593427	0	tyrosine	20,28	Jak2	15,19	tyrosine	Jak2	CHEBI:18186	3717	Chemical	Gene	START_ENTITY|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of Jak2 tyrosine phosphorylation in Bcr-Abl transformation .
11875116	0	tyrosine	21,29	Jak2	0,4	tyrosine	Jak2	CHEBI:18186	16452(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|nsubj|END_ENTITY	Jak2 is an essential tyrosine kinase involved in pregnancy-mediated development of mammary secretory epithelium .
12686600	0	tyrosine	23,31	Jak2	18,22	tyrosine	Jak2	CHEBI:18186	3717	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Autoinhibition of Jak2 tyrosine kinase is dependent on specific regions in its pseudokinase domain .
14551204	0	tyrosine	5,13	Jak2	0,4	tyrosine	Jak2	CHEBI:18186	3717	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Jak2 tyrosine kinase mediates angiotensin_II-dependent inactivation of ERK2 via induction of mitogen-activated_protein_kinase_phosphatase_1 .
15475610	0	tyrosine	5,13	Jak2	0,4	tyrosine	Jak2	CHEBI:18186	3717	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Jak2 tyrosine kinase : a true jak of all trades ?
16257270	0	tyrosine	5,13	Jak2	0,4	tyrosine	Jak2	CHEBI:18186	24514(Tax:10116)	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Jak2 tyrosine kinase prevents angiotensin_II-mediated inositol_1 ,4,5 _ trisphosphate receptor degradation .
16456223	0	tyrosine	5,13	Jak2	0,4	tyrosine	Jak2	CHEBI:18186	3717	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Jak2 tyrosine kinase : a mediator of both housekeeping and ligand-dependent gene expression ?
18054268	0	tyrosine	90,98	Jak2	85,89	tyrosine	Jak2	CHEBI:18186	3717	Chemical	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	Hydrogen_peroxide stimulates tetrahydrobiopterin synthesis through activation of the Jak2 tyrosine kinase pathway in vascular endothelial cells .
21726629	0	tyrosine	45,53	Jak2	40,44	tyrosine	Jak2	CHEBI:18186	3717	Chemical	Gene	activation|compound|START_ENTITY activation|amod|END_ENTITY	Phosphorylation of Y372 is critical for Jak2 tyrosine kinase activation .
7534285	0	tyrosine	45,53	Jak2	73,77	tyrosine	Jak2	CHEBI:18186	16452(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	The c-Mpl_ligand -LRB- thrombopoietin -RRB- stimulates tyrosine phosphorylation of Jak2 , Shc , and c-Mpl .
8977232	1	tyrosine	210,218	Jak2	205,209	tyrosine	IL-3	CHEBI:18186	3562	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Erythropoietin -LRB- Epo -RRB- and interleukin-3 -LRB- IL-3 -RRB- stimulate activation of the Jak2 tyrosine kinase and induce tyrosine phosphorylation and activation of Stat5 .
9464845	0	tyrosine	99,107	Jak2	94,98	tyrosine	Jak2	CHEBI:18186	3717	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Anti-apoptotic signals of granulocyte-macrophage_colony-stimulating_factor are transduced via Jak2 tyrosine kinase in eosinophils .
9657743	0	tyrosine	23,31	Jak2	51,55	tyrosine	Jak2	CHEBI:18186	3717	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Erythropoietin induces tyrosine phosphorylation of Jak2 , STAT5A , and STAT5B in primary cultured human erythroid precursors .
9822675	0	tyrosine	58,66	Jak2	86,90	tyrosine	Jak2	CHEBI:18186	3717	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Induction of 15-lipoxygenase expression by IL-13 requires tyrosine phosphorylation of Jak2 and Tyk2 in human monocytes .
10037026	0	tyrosine	72,80	Jak3	138,142	tyrosine	Jak3	CHEBI:18186	3718	Chemical	Gene	kinases|amod|START_ENTITY capabilities|nmod|kinases capabilities|dep|END_ENTITY	Differential substrate recognition capabilities of Janus family protein tyrosine kinases within the interleukin_2_receptor -LRB- IL2R -RRB- system : Jak3 as a potential molecular target for treatment of leukemias with a hyperactive Jak-Stat signaling machinery .
10553066	0	tyrosine	15,23	Jak3	31,35	tyrosine	Jak3	CHEBI:18186	16453(Tax:10090)	Chemical	Gene	START_ENTITY|ccomp|required required|nsubjpass|END_ENTITY	The Jak family tyrosine kinase Jak3 is required for IL-2 synthesis by naive/resting CD4 + T cells .
10825200	0	tyrosine	21,29	Jak3	102,106	tyrosine	Jak3	CHEBI:18186	3718	Chemical	Gene	Hierarchy|nmod|START_ENTITY kinases|nsubj|Hierarchy kinases|parataxis|depends depends|nmod|END_ENTITY	Hierarchy of protein tyrosine kinases in interleukin-2 -LRB- IL-2 -RRB- signaling : activation of syk depends on Jak3 ; however , neither Syk nor Lck is required for IL-2-mediated STAT activation .
12351625	0	tyrosine	87,95	Jak3	82,86	tyrosine	Jak3	CHEBI:18186	3718	Chemical	Gene	kinases|compound|START_ENTITY kinases|amod|END_ENTITY	The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction .
7479924	0	tyrosine	90,98	Jak3	155,159	tyrosine	Jak3	CHEBI:18186	3718	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|Janus_protein-tyrosine_kinase_3 Janus_protein-tyrosine_kinase_3|appos|END_ENTITY	Staphylococcal_enterotoxins modulate interleukin 2 receptor expression and ligand-induced tyrosine phosphorylation of the Janus_protein-tyrosine_kinase_3 -LRB- Jak3 -RRB- and signal transducers and activators of transcription -LRB- Stat proteins -RRB- .
9022047	0	tyrosine	65,73	Jak3	82,86	tyrosine	Jak3	CHEBI:18186	16453(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	Genomic structure and promoter region of the murine Janus-family tyrosine kinase , Jak3 .
9446656	0	tyrosine	174,182	Jak3	169,173	tyrosine	Jak3	CHEBI:18186	3718	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Development of autologous , oligoclonal , poorly functioning T lymphocytes in a patient with autosomal recessive severe_combined_immunodeficiency caused by defects of the Jak3 tyrosine kinase .
10229872	0	tyrosine	38,46	Janus_kinase-2	81,95	tyrosine	Janus kinase-2	CHEBI:18186	16452(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrphostin_B42 inhibits IL-12-induced tyrosine phosphorylation and activation of Janus_kinase-2 and prevents experimental_allergic_encephalomyelitis .
7795229	0	tyrosine	49,57	Janus_kinase_2	77,91	tyrosine	Janus kinase 2	CHEBI:18186	3717	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Recombinant thrombopoietin induces rapid protein tyrosine phosphorylation of Janus_kinase_2 and Shc in human blood platelets .
9916733	0	tyrosine	37,45	Janus_kinase_3	65,79	tyrosine	Janus kinase 3	CHEBI:18186	16453(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	IgE hyperproduction through enhanced tyrosine phosphorylation of Janus_kinase_3 in NC/Nga mice , a model for human atopic_dermatitis .
7479924	0	tyrosine	90,98	Janus_protein-tyrosine_kinase_3	122,153	tyrosine	Janus protein-tyrosine kinase 3	CHEBI:18186	3718	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Staphylococcal_enterotoxins modulate interleukin 2 receptor expression and ligand-induced tyrosine phosphorylation of the Janus_protein-tyrosine_kinase_3 -LRB- Jak3 -RRB- and signal transducers and activators of transcription -LRB- Stat proteins -RRB- .
20600929	5	tyrosine	825,833	KCC2	857,861	tyrosine	KCC2	CHEBI:18186	57468	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Here we demonstrate that in HEK-293 cells the principal sites of tyrosine phosphorylation within KCC2 are residues 903 and 1087 -LRB- Y903/1087 -RRB- , which lie within the major C-terminal intracellular domain of KCC2 .
10037737	0	tyrosine	48,56	KDR	44,47	tyrosine	KDR	CHEBI:18186	3791	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Vascular_endothelial_growth_factor receptor KDR tyrosine kinase activity is increased by autophosphorylation of two activation loop tyrosine residues .
11312112	4	tyrosine	699,707	KDR	678,681	tyrosine	NRP	CHEBI:18186	397804(Tax:8355)	Chemical	Gene	kinase|compound|START_ENTITY END_ENTITY|appos|kinase	On the endothelium , NRP is expressed together with KDR , a VEGF receptor tyrosine kinase .
11335727	0	tyrosine	108,116	KDR	95,98	tyrosine	KDR	CHEBI:18186	3791	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Vascular_endothelial_cell_growth_factor activates CRE-binding_protein by signaling through the KDR receptor tyrosine kinase .
8245783	0	tyrosine	41,49	KDR	28,31	tyrosine	KDR	CHEBI:18186	3791	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	The related FLT4 , FLT1 , and KDR receptor tyrosine kinases show distinct expression patterns in human fetal endothelial cells .
11896121	0	tyrosine	18,26	KIT	14,17	tyrosine	KIT	CHEBI:18186	3815	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Inhibition of KIT tyrosine kinase activity : a novel molecular approach to the treatment of KIT-positive malignancies .
16021678	0	tyrosine	68,76	KIT	32,35	tyrosine	KIT	CHEBI:18186	3815	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Amplification of genes encoding KIT , PDGFRalpha and VEGFR2 receptor tyrosine kinases is frequent in glioblastoma multiforme .
16912224	0	tyrosine	19,27	KIT	120,123	tyrosine	KIT	CHEBI:18186	3815	Chemical	Gene	inhibitor|amod|START_ENTITY EXEL-0862|appos|inhibitor induces|nsubj|EXEL-0862 induces|advcl|expressing expressing|dobj|mutation mutation|compound|END_ENTITY	EXEL-0862 , a novel tyrosine kinase inhibitor , induces apoptosis in vitro and ex vivo in human mast cells expressing the KIT D816V mutation .
17337216	0	tyrosine	27,35	KIT	14,17	tyrosine	KIT	CHEBI:18186	3815	Chemical	Gene	START_ENTITY|nsubj|Expression Expression|nmod|receptor receptor|compound|END_ENTITY	Expression of KIT receptor tyrosine kinase protein in normal human skin : preliminary observations .
17662946	0	tyrosine	48,56	KIT	64,67	tyrosine	KIT	CHEBI:18186	3815	Chemical	Gene	activation|nmod|START_ENTITY basis|nmod|activation kinase|nsubj|basis kinase|dobj|END_ENTITY	Structural basis for activation of the receptor tyrosine kinase KIT by stem_cell_factor .
17949810	0	tyrosine	14,22	KIT	0,3	tyrosine	KIT	CHEBI:18186	3815	Chemical	Gene	phosphorylation|amod|START_ENTITY regulates|dobj|phosphorylation regulates|nsubj|END_ENTITY	KIT regulates tyrosine phosphorylation and nuclear localization of beta-catenin in mast_cell_leukemia .
18084259	0	tyrosine	127,135	KIT	20,23	tyrosine	KIT	CHEBI:18186	3815	Chemical	Gene	tumorigenesis|amod|START_ENTITY implications|nmod|tumorigenesis mutations|dep|implications mutations|nmod|END_ENTITY	Silent mutations in KIT and PDGFRA and coexpression of receptors with SCF and PDGFA_in_Merkel_cell_carcinoma : implications for tyrosine kinase-based tumorigenesis .
19789626	0	tyrosine	43,51	KIT	79,82	tyrosine	KIT	CHEBI:18186	16590(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY Masitinib|appos|kinase inhibitor|nsubj|Masitinib inhibitor|xcomp|targeting targeting|dobj|END_ENTITY	Masitinib -LRB- AB1010 -RRB- , a potent and selective tyrosine kinase inhibitor targeting KIT .
20095048	0	tyrosine	45,53	KIT	41,44	tyrosine	KIT	CHEBI:18186	3815	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Drug binding and resistance mechanism of KIT tyrosine kinase revealed by hydrogen/deuterium exchange FTICR mass spectrometry .
23887971	0	tyrosine	90,98	KIT	0,3	tyrosine	KIT	CHEBI:18186	16590(Tax:10090)	Chemical	Gene	progenitors|xcomp|START_ENTITY progenitors|nsubj|END_ENTITY	KIT signaling governs differential sensitivity of mature and primitive CML progenitors to tyrosine kinase inhibitors .
24127596	0	tyrosine	34,42	KIT	21,24	tyrosine	KIT	CHEBI:18186	3815	Chemical	Gene	START_ENTITY|nsubj|basis basis|nmod|receptor receptor|compound|END_ENTITY	Structural basis for KIT receptor tyrosine kinase inhibition by antibodies targeting the D4 membrane-proximal region .
25088577	0	tyrosine	27,35	KIT	108,111	tyrosine	KIT	CHEBI:18186	3815	Chemical	Gene	START_ENTITY|ccomp|induce induce|dobj|apoptosis apoptosis|nmod|cells cells|acl|expressing expressing|dobj|mutation mutation|compound|END_ENTITY	Novel thiazole_amine class tyrosine kinase inhibitors induce apoptosis in human mast cells expressing D816V KIT mutation .
25216797	0	tyrosine	14,22	KIT	37,40	tyrosine	KIT	CHEBI:18186	3815	Chemical	Gene	START_ENTITY|ccomp|predicts predicts|nsubj|transcript transcript|appos|FLT3 FLT3|dep|END_ENTITY	High receptor tyrosine kinase -LRB- FLT3 , KIT -RRB- transcript versus anti-apoptotic -LRB- BCL2 -RRB- transcript ratio independently predicts inferior outcome in pediatric acute_myeloid_leukemia .
9027509	0	tyrosine	81,89	KIT	56,59	tyrosine	KIT	CHEBI:18186	3815	Chemical	Gene	START_ENTITY|nsubj|analysis analysis|nmod|regions regions|acl|containing containing|dobj|END_ENTITY	Sequence analysis of two genomic regions containing the KIT and the FMS receptor tyrosine kinase genes .
9665195	0	tyrosine	51,59	KIT	47,50	tyrosine	KIT	CHEBI:18186	16590(Tax:10090)	Chemical	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	Specific and common activities of the FLT3 and KIT tyrosine kinase receptors revealed by the use of cultured mast cells .
9796694	0	tyrosine	49,57	KIT	45,48	tyrosine	KIT	CHEBI:18186	16590(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Inhibition of p53-dependent apoptosis by the KIT tyrosine kinase : regulation of mitochondrial permeability transition and reactive oxygen species generation .
15086281	1	tyrosine	254,262	Kit	316,319	tyrosine	Kit	CHEBI:18186	3815	Chemical	Gene	protein|compound|START_ENTITY directed|nmod|protein agents|acl|directed development|nmod|agents generated|nsubj|development generated|nmod|immunoreactivity immunoreactivity|compound|END_ENTITY	CONTEXT : The development of successful chemotherapeutic agents directed against the Kit receptor tyrosine kinase protein has generated intense interest in the Kit -LRB- CD117 -RRB- immunoreactivity of various neoplasms .
16579756	0	tyrosine	44,52	Kit	61,64	tyrosine	Kit	CHEBI:18186	403811(Tax:9615)	Chemical	Gene	dysregulation|nmod|START_ENTITY Evaluation|nmod|dysregulation kinases|nsubj|Evaluation kinases|dobj|END_ENTITY	Evaluation of dysregulation of the receptor tyrosine kinases Kit , Flt3 , and Met in histiocytic_sarcomas of dogs .
23377219	0	tyrosine	40,48	Kit	27,30	tyrosine	Kit	CHEBI:18186	493766(Tax:9685)	Chemical	Gene	START_ENTITY|nsubj|significance significance|nmod|receptor receptor|compound|END_ENTITY	Prognostic significance of Kit receptor tyrosine kinase dysregulations in feline cutaneous mast_cell_tumors .
8962111	0	tyrosine	39,47	Kit	26,29	tyrosine	Kit	CHEBI:18186	16590(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Oncogenic mutation in the Kit receptor tyrosine kinase alters substrate specificity and induces degradation of the protein tyrosine phosphatase SHP-1 .
12789265	0	tyrosine	20,28	Kos1	0,4	tyrosine	Kos1	CHEBI:18186	83813(Tax:10090)	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|advmod|END_ENTITY	Kos1 , a nonreceptor tyrosine kinase that suppresses Ras signaling .
10699984	0	tyrosine	22,30	LAR	18,21	tyrosine	LAR	CHEBI:18186	360406(Tax:10116)	Chemical	Gene	phosphatase|amod|START_ENTITY phosphatase|compound|END_ENTITY	Downregulation of LAR tyrosine phosphatase prevents apoptosis and augments NGF-induced neurite outgrowth .
10822386	0	tyrosine	80,88	LAR	101,104	tyrosine	LAR	CHEBI:18186	5792	Chemical	Gene	activation|nmod|START_ENTITY inhibition|nmod|activation phosphatase|nsubj|inhibition phosphatase|dobj|END_ENTITY	Specific inhibition of FGF-induced MAPK activation by the receptor-like protein tyrosine phosphatase LAR .
11158333	0	tyrosine	112,120	LAR	70,73	tyrosine	LAR	CHEBI:18186	5792	Chemical	Gene	dephosphorylation|amod|START_ENTITY tyrosine|nmod|dephosphorylation tyrosine|dobj|domains domains|nmod|END_ENTITY	Distinct functions of the two protein tyrosine phosphatase domains of LAR -LRB- leukocyte common antigen-related -RRB- on tyrosine dephosphorylation of insulin_receptor .
11158333	0	tyrosine	38,46	LAR	70,73	tyrosine	LAR	CHEBI:18186	5792	Chemical	Gene	START_ENTITY|dobj|domains domains|nmod|END_ENTITY	Distinct functions of the two protein tyrosine phosphatase domains of LAR -LRB- leukocyte common antigen-related -RRB- on tyrosine dephosphorylation of insulin_receptor .
11836260	0	tyrosine	59,67	LAR	41,44	tyrosine	LAR	CHEBI:18186	5792	Chemical	Gene	proteins|compound|START_ENTITY proteins|compound|END_ENTITY	Liprin_beta_1 , a member of the family of LAR transmembrane tyrosine phosphatase-interacting proteins , is a new target for the metastasis-associated_protein_S100A4 -LRB- Mts1 -RRB- .
12095414	0	tyrosine	57,65	LAR	52,55	tyrosine	LAR	CHEBI:18186	5792	Chemical	Gene	phosphatase|amod|START_ENTITY phosphatase|appos|END_ENTITY	Expression of the leucocyte common antigen-related -LRB- LAR -RRB- tyrosine phosphatase is regulated by cell density through functional E-cadherin complexes .
15674434	0	tyrosine	52,60	LAR	31,34	tyrosine	LAR	CHEBI:18186	5792	Chemical	Gene	START_ENTITY|nsubj|significance significance|nmod|protein protein|compound|END_ENTITY	Functional significance of the LAR receptor protein tyrosine phosphatase family in development and diseases .
15770063	0	tyrosine	15,23	LAR	36,39	tyrosine	LAR	CHEBI:18186	5792	Chemical	Gene	phosphatase|amod|START_ENTITY Detection|nmod|phosphatase END_ENTITY|nsubj|Detection	Detection of a tyrosine phosphatase LAR on intestinal epithelial cells and intraepithelial lymphocytes in the human duodenum .
15896785	0	tyrosine	26,34	LAR	14,17	tyrosine	LAR	CHEBI:18186	5792	Chemical	Gene	phosphatase|amod|START_ENTITY phosphatase|compound|END_ENTITY	Knock-down of LAR protein tyrosine phosphatase induces insulin resistance .
16213816	0	tyrosine	95,103	LAR	82,85	tyrosine	LAR	CHEBI:18186	35259(Tax:7227)	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|compound|END_ENTITY	The heparan sulfate proteoglycan syndecan is an in vivo ligand for the Drosophila LAR receptor tyrosine phosphatase .
16262654	0	tyrosine	55,63	LAR	43,46	tyrosine	LAR	CHEBI:18186	104121(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Identification Identification|nmod|ectodomain ectodomain|nmod|protein protein|compound|END_ENTITY	Identification of an ectodomain within the LAR protein tyrosine phosphatase receptor that binds homophilically and activates signalling pathways promoting neurite outgrowth .
16488625	0	tyrosine	34,42	LAR	22,25	tyrosine	LAR	CHEBI:18186	104121(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Downregulation of the LAR protein tyrosine phosphatase receptor is associated with increased dentate gyrus neurogenesis and an increased number of granule cell layer neurons .
17013927	0	tyrosine	12,20	LAR	0,3	tyrosine	LAR	CHEBI:18186	5792	Chemical	Gene	START_ENTITY|nsubj|protein protein|compound|END_ENTITY	LAR protein tyrosine phosphatase receptor associates with TrkB and modulates neurotrophic signaling pathways .
19889974	0	tyrosine	21,29	LAR	42,45	tyrosine	LAR	CHEBI:18186	35259(Tax:7227)	Chemical	Gene	phosphatase|nsubj|START_ENTITY phosphatase|ccomp|promotes promotes|nsubj|END_ENTITY	The receptor protein tyrosine phosphatase LAR promotes R7 photoreceptor axon targeting by a phosphatase-independent signaling mechanism .
19910497	0	tyrosine	48,56	LAR	44,47	tyrosine	LAR	CHEBI:18186	5792	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|differentiation differentiation|nmod|END_ENTITY	Regulation of adipogenic differentiation by LAR tyrosine phosphatase in human mesenchymal stem cells and 3T3-L1 preadipocytes .
23358419	0	tyrosine	17,25	LAR	113,116	tyrosine	LAR	CHEBI:18186	5792	Chemical	Gene	phosphatase-receptor|compound|START_ENTITY tyrosine|nsubj|phosphatase-receptor tyrosine|ccomp|identifies identifies|nmod|target target|nmod|END_ENTITY	Receptor protein tyrosine phosphatase-receptor tyrosine kinase substrate screen identifies EphA2 as a target for LAR in cell migration .
23358419	0	tyrosine	47,55	LAR	113,116	tyrosine	LAR	CHEBI:18186	5792	Chemical	Gene	START_ENTITY|ccomp|identifies identifies|nmod|target target|nmod|END_ENTITY	Receptor protein tyrosine phosphatase-receptor tyrosine kinase substrate screen identifies EphA2 as a target for LAR in cell migration .
27074791	0	tyrosine	71,79	LAR	59,62	tyrosine	LAR	D014443	104121(Tax:10090)	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|compound|END_ENTITY	Regulation of platelet derived growth factor signalling by LAR protein tyrosine phosphatase : a quantitative phosphoproteomics study .
7929208	0	tyrosine	46,54	LAR	34,37	tyrosine	LAR	CHEBI:18186	5792	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Genomic organization of the human LAR protein tyrosine phosphatase gene and alternative splicing in the extracellular fibronectin type-III domains .
9207225	0	tyrosine	12,20	LAR	33,36	tyrosine	LAR	CHEBI:18186	360406(Tax:10116)	Chemical	Gene	phosphatase|nsubj|START_ENTITY phosphatase|ccomp|has has|nsubj|END_ENTITY	The protein tyrosine phosphatase LAR has a major impact on insulin_receptor dephosphorylation .
9245518	0	tyrosine	82,90	LAR	64,67	tyrosine	LAR	CHEBI:18186	104121(Tax:10090)	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Impaired mammary gland development and function in mice lacking LAR receptor-like tyrosine phosphatase activity .
9245795	0	tyrosine	35,43	LAR	57,60	tyrosine	LAR	CHEBI:18186	5792	Chemical	Gene	redistribution|nmod|START_ENTITY phosphatases|nsubj|redistribution phosphatases|dobj|END_ENTITY	Cellular redistribution of protein tyrosine phosphatases LAR and PTPsigma by inducible proteolytic processing .
9268718	0	tyrosine	27,35	LAR	48,51	tyrosine	LAR	CHEBI:18186	360406(Tax:10116)	Chemical	Gene	Suppression|nmod|START_ENTITY phosphatase|nsubj|Suppression phosphatase|ccomp|reduces reduces|nsubj|END_ENTITY	Suppression of the protein tyrosine phosphatase LAR reduces apolipoprotein_B secretion by McA-RH7777 rat hepatoma cells .
9501065	0	tyrosine	36,44	LAR	57,60	tyrosine	LAR	CHEBI:18186	5792	Chemical	Gene	Overexpression|nmod|START_ENTITY phosphatase|nsubj|Overexpression phosphatase|ccomp|activates activates|nsubj|END_ENTITY	Overexpression of the transmembrane tyrosine phosphatase LAR activates the caspase pathway and induces apoptosis .
9526016	0	tyrosine	13,21	LAR	42,45	tyrosine	LAR	CHEBI:18186	35259(Tax:7227)	Chemical	Gene	phosphatases|compound|START_ENTITY phosphatases|nmod|family family|compound|END_ENTITY	Two receptor tyrosine phosphatases of the LAR family are expressed in the developing leech by specific central neurons as well as select peripheral neurons , muscles , and other cells .
9647658	0	tyrosine	99,107	LAR	120,123	tyrosine	LAR	CHEBI:18186	5792	Chemical	Gene	isoform|nmod|START_ENTITY ligand|nmod|isoform END_ENTITY|amod|ligand	The laminin-nidogen complex is a ligand for a specific splice isoform of the transmembrane protein tyrosine phosphatase LAR .
9784606	0	tyrosine	68,76	LAR	90,93	tyrosine	LAR	CHEBI:18186	104121(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY phosphatases|nsubj|expression phosphatases|dobj|END_ENTITY	Developmental expression of the cell adhesion molecule-like protein tyrosine phosphatases LAR , RPTPdelta and RPTPsigma in the mouse .
10358158	0	tyrosine	45,53	LAT	73,76	tyrosine	LAT	CHEBI:18186	16797(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Perturbed regulation of ZAP-70 and sustained tyrosine phosphorylation of LAT and SLP-76 in c-Cbl-deficient thymocytes .
10427998	0	tyrosine	28,36	LAT	76,79	tyrosine	LAT	CHEBI:18186	27040	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	CD28 ligation induces rapid tyrosine phosphorylation of the linker molecule LAT in the absence of Syk and ZAP-70 tyrosine phosphorylation .
10567557	0	tyrosine	20,28	LAT	0,3	tyrosine	LAT	CHEBI:18186	16797(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY required|nmod|phosphorylation required|nsubjpass|END_ENTITY	LAT is required for tyrosine phosphorylation of phospholipase_cgamma2 and platelet activation by the collagen receptor GPVI .
10593514	0	tyrosine	72,80	LAT	118,121	tyrosine	LAT	CHEBI:18186	27040	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Thy-1 / CD3 coengagement promotes TCR signaling and enhances particularly tyrosine phosphorylation of the raft molecule LAT .
10811803	0	tyrosine	79,87	LAT	75,78	tyrosine	LAT	CHEBI:18186	27040	Chemical	Gene	residues|compound|START_ENTITY residues|compound|END_ENTITY	Association of Grb2 , Gads , and phospholipase_C-gamma_1 with phosphorylated LAT tyrosine residues .
10811803	1	tyrosine	112,120	LAT	108,111	tyrosine	LAT	CHEBI:18186	27040	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling .
12209631	0	tyrosine	62,70	LAT	106,109	tyrosine	LAT	CHEBI:18186	27040	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Lipid rafts as the signaling scaffold for NK cell activation : tyrosine phosphorylation and association of LAT with phosphatidylinositol_3-kinase and phospholipase C-gamma following CD2 stimulation .
17579183	0	tyrosine	24,32	LAT	45,48	tyrosine	LAT	CHEBI:18186	27040	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Roles of the C-terminal tyrosine residues of LAT in GPVI-induced platelet activation : insights into the mechanism of PLC_gamma_2 activation .
10706447	0	tyrosine	29,37	LCK	45,48	tyrosine	LCK	CHEBI:18186	3932	Chemical	Gene	Dysregulation|nmod|START_ENTITY kinase|nsubj|Dysregulation kinase|dobj|END_ENTITY	Dysregulation of the protein tyrosine kinase LCK in lymphoproliferative_disorders and in other neoplasias .
16107303	0	tyrosine	61,69	LCK	77,80	tyrosine	LCK	CHEBI:18186	3932	Chemical	Gene	variant|nmod|START_ENTITY kinase|nsubj|variant kinase|xcomp|protein protein|nsubj|gene gene|compound|END_ENTITY	A rare mRNA variant of the human lymphocyte-specific protein tyrosine kinase LCK gene with intron B retention and exon 7 skipping encodes a putative protein with altered SH3-dependent molecular interactions .
8062594	0	tyrosine	61,69	LCK	83,86	tyrosine	LCK	CHEBI:18186	3932	Chemical	Gene	START_ENTITY|dobj|gene gene|appos|END_ENTITY	Subregional mapping of the human lymphocyte-specific protein tyrosine kinase gene -LRB- LCK -RRB- to 1p35 -- > p34 .3 and its position relative to the 1p marker D1S57 .
8609388	0	tyrosine	22,30	LCK	73,76	tyrosine	LCK	CHEBI:18186	3932	Chemical	Gene	kinase|amod|START_ENTITY EMT/ITK/TSK|amod|kinase activated|nsubjpass|EMT/ITK/TSK activated|parataxis|required required|nsubjpass|END_ENTITY	The EMT/ITK/TSK -LRB- EMT -RRB- tyrosine kinase is activated during TCR signaling : LCK is required for optimal activation of EMT .
8636141	0	tyrosine	82,90	LCK	11,14	tyrosine	LCK	CHEBI:18186	3932	Chemical	Gene	EMT/ITK|compound|START_ENTITY activation|nmod|EMT/ITK required|nmod|activation required|nsubjpass|END_ENTITY	Functional LCK Is required for optimal CD28-mediated activation of the TEC family tyrosine kinase EMT/ITK .
9305640	0	tyrosine	27,35	LCK	15,18	tyrosine	LCK	CHEBI:18186	3932	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	S-acylation of LCK protein tyrosine kinase is essential for its signalling function in T lymphocytes .
9494076	0	tyrosine	135,143	LCK	151,154	tyrosine	LCK	CHEBI:18186	3932	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	Efficient CD28 signalling leads to increases in the kinase activities of the TEC family tyrosine kinase EMT/ITK/TSK and the SRC family tyrosine kinase LCK .
12789267	0	tyrosine	29,37	LDL_receptor-related_protein_1	74,104	tyrosine	LDL receptor-related protein 1	CHEBI:18186	16971(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	v-Src induces Shc binding to tyrosine 63 in the cytoplasmic domain of the LDL_receptor-related_protein_1 .
9491893	0	tyrosine	78,86	LET-23	62,68	tyrosine	LET-23	CHEBI:18186	174462(Tax:6239)	Chemical	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Inositol_trisphosphate mediates a RAS-independent response to LET-23 receptor tyrosine kinase activation in C. _ elegans .
7499207	1	tyrosine	191,199	LFA_1	219,224	tyrosine	LFA 1	CHEBI:18186	3683	Chemical	Gene	START_ENTITY|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Role of calcium signaling and tyrosine phosphorylation of LFA_1 .
20142099	0	tyrosine	78,86	LKB1	106,110	tyrosine	LKB1	CHEBI:18186	20869(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Fyn-dependent regulation of energy expenditure and body weight is mediated by tyrosine phosphorylation of LKB1 .
15358193	0	tyrosine	12,20	LMW-PTP	91,98	tyrosine	LMW-PTP	CHEBI:18186	52	Chemical	Gene	level|amod|START_ENTITY The|nmod|level influenced|nsubjpass|The influenced|nmod|Ltp1 Ltp1|compound|END_ENTITY	The in vivo tyrosine phosphorylation level of yeast immunophilin Fpr3 is influenced by the LMW-PTP Ltp1 .
17428749	0	tyrosine	29,37	LMW-PTP	51,58	tyrosine	LMW-PTP	CHEBI:18186	11431(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|phosphatase phosphatase|appos|END_ENTITY	Low molecular weight protein tyrosine phosphatase -LRB- LMW-PTP -RRB- and its possible physiological functions of redox signaling in the eye lens .
18604186	0	tyrosine	55,63	LMW-PTP	77,84	tyrosine	LMW-PTP	CHEBI:18186	52	Chemical	Gene	phosphatase|amod|START_ENTITY protein|amod|phosphatase protein|appos|END_ENTITY	-LSB- Genetic polymorphisms of low molecular weight protein tyrosine phosphatase -LRB- LMW-PTP -RRB- : relationship with erythrocyte enzymatic phenotype in patients with Systemic_Lupus_Erythematosus -RSB- .
19414171	0	tyrosine	53,61	LMW-PTP	75,82	tyrosine	LMW-PTP	CHEBI:18186	52	Chemical	Gene	START_ENTITY|dobj|activity activity|appos|END_ENTITY	A possible mechanism of low molecular weight protein tyrosine phosphatase -LRB- LMW-PTP -RRB- activity modulation by glutathione action during human osteoblast differentiation .
25811796	0	tyrosine	29,37	LMWPTP	51,57	tyrosine	LMWPTP	D014443	52	Chemical	Gene	upregulation|compound|START_ENTITY upregulation|appos|END_ENTITY	Low molecular weight protein tyrosine phosphatase -LRB- LMWPTP -RRB- upregulation mediates malignant potential in colorectal_cancer .
25331893	0	tyrosine	39,47	LTK	56,59	tyrosine	LTK	CHEBI:18186	4058	Chemical	Gene	START_ENTITY|dobj|receptor receptor|appos|END_ENTITY	Deorphanization of the human leukocyte tyrosine kinase -LRB- LTK -RRB- receptor by a signaling screen of the extracellular proteome .
8125304	0	tyrosine	48,56	LYN	36,39	tyrosine	LYN	CHEBI:18186	4067	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The cDNAs encoding two forms of the LYN protein tyrosine kinase are expressed in rat mast cells and human myeloid cells .
15531553	0	tyrosine	48,56	LYP	70,73	tyrosine	LYP	CHEBI:18186	26191	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The codon 620 tryptophan allele of the lymphoid tyrosine phosphatase -LRB- LYP -RRB- gene is a major determinant of Graves ' _ disease .
21044313	0	tyrosine	36,44	LYP	57,60	tyrosine	LYP	CHEBI:18186	26191	Chemical	Gene	phosphatase|amod|START_ENTITY form|nmod|phosphatase Identification|nmod|form END_ENTITY|nsubj|Identification	Identification of a variant form of tyrosine phosphatase LYP .
10221654	0	tyrosine	6,14	Lck	34,37	tyrosine	Lck	CHEBI:18186	3932	Chemical	Gene	START_ENTITY|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Rapid tyrosine phosphorylation of Lck following ligation of the tumor-associated cell surface molecule A6H .
10848956	0	tyrosine	12,20	Lck	0,3	tyrosine	Lck	CHEBI:18186	3932	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Lck protein tyrosine kinase is a key regulator of T-cell activation and a target for signal intervention by Herpesvirus_saimiri and other viral gene products .
10975838	0	tyrosine	16,24	Lck	12,15	tyrosine	Lck	CHEBI:18186	3932	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Serine 6 of Lck tyrosine kinase : a critical site for Lck myristoylation , membrane localization , and function in T lymphocytes .
11020319	6	tyrosine	1272,1280	Lck	1289,1292	tyrosine	Lck	CHEBI:18186	3932	Chemical	Gene	kinase|amod|START_ENTITY protein|amod|kinase protein|appos|END_ENTITY	Both the direct and indirect FP-PTK immunoassays have been compared with a more commonly used -LRB- 32 -RRB- PO -LRB- 4 -RRB- transfer assay and validated using lymphoid T-cell protein tyrosine kinase -LRB- Lck -RRB- .
11040125	0	tyrosine	22,30	Lck	18,21	tyrosine	Lck	CHEBI:18186	3932	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Activation of the Lck tyrosine protein kinase by the Herpesvirus_saimiri tip protein involves two binding interactions .
11168636	0	tyrosine	39,47	Lck	27,30	tyrosine	Lck	CHEBI:18186	3932	Chemical	Gene	START_ENTITY|nsubj|activation activation|nmod|END_ENTITY	Constitutive activation of Lck and Fyn tyrosine kinases in large granular lymphocytes infected with the gamma-herpesvirus agents of malignant_catarrhal_fever .
11274732	0	tyrosine	36,44	Lck	32,35	tyrosine	Lck	CHEBI:18186	3932	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|cysteine cysteine|nmod|END_ENTITY	A pivotal role of cysteine 3 of Lck tyrosine kinase for localization to glycolipid-enriched microdomains and T cell activation .
11294838	0	tyrosine	38,46	Lck	34,37	tyrosine	Lck	CHEBI:18186	16818(Tax:10090)	Chemical	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Specific dephosphorylation of the Lck tyrosine protein kinase at Tyr-394 by the SHP-1 protein-tyrosine phosphatase .
11955060	0	tyrosine	86,94	Lck	102,105	tyrosine	Lck	CHEBI:18186	3932	Chemical	Gene	domain|nmod|START_ENTITY investigation|nmod|domain kinase|nsubj|investigation kinase|dobj|END_ENTITY	Structural investigation of the binding of a herpesviral protein to the SH3 domain of tyrosine kinase Lck .
12115650	0	tyrosine	4,12	Lck	0,3	tyrosine	Lck	CHEBI:18186	3932	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Lck tyrosine kinase is important for activation of the CD11a/CD18-integrins in human T lymphocytes .
12496362	0	tyrosine	26,34	Lck	14,17	tyrosine	Lck	CHEBI:18186	3932	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of Lck and Fyn tyrosine kinase activities by transmembrane protein tyrosine phosphatase leukocyte common antigen-related molecule .
12496362	0	tyrosine	78,86	Lck	14,17	tyrosine	Lck	CHEBI:18186	3932	Chemical	Gene	phosphatase|compound|START_ENTITY activities|nmod|phosphatase leukocyte|nsubj|activities tyrosine|ccomp|leukocyte tyrosine|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of Lck and Fyn tyrosine kinase activities by transmembrane protein tyrosine phosphatase leukocyte common antigen-related molecule .
12589038	0	tyrosine	18,26	Lck	124,127	tyrosine	Lck	CHEBI:18186	3932	Chemical	Gene	phosphorylation|compound|START_ENTITY regulated|nsubjpass|phosphorylation regulated|nmod|phosphorylations phosphorylations|nmod|END_ENTITY	Integrin-mediated tyrosine phosphorylation of Shc in T cells is regulated by protein kinase C-dependent phosphorylations of Lck .
12755691	0	tyrosine	117,125	Lck	133,136	tyrosine	Lck	CHEBI:18186	3932	Chemical	Gene	T-cell_receptor_zeta_chain|nmod|START_ENTITY END_ENTITY|amod|T-cell_receptor_zeta_chain	Investigation of the kinetics and order of tyrosine phosphorylation in the T-cell_receptor_zeta_chain by the protein tyrosine kinase Lck .
12755691	0	tyrosine	43,51	Lck	133,136	tyrosine	Lck	CHEBI:18186	3932	Chemical	Gene	phosphorylation|amod|START_ENTITY kinetics|nmod|phosphorylation Investigation|nmod|kinetics Investigation|nmod|END_ENTITY	Investigation of the kinetics and order of tyrosine phosphorylation in the T-cell_receptor_zeta_chain by the protein tyrosine kinase Lck .
12810359	0	tyrosine	53,61	Lck	71,74	tyrosine	Lck	CHEBI:18186	3932	Chemical	Gene	kinases|amod|START_ENTITY kinases|appos|END_ENTITY	Dopamine inhibits cytokine release and expression of tyrosine kinases , Lck and Fyn in activated T cells .
15214778	0	tyrosine	84,92	Lck	104,107	tyrosine	Lck	CHEBI:18186	3932	Chemical	Gene	domain|amod|START_ENTITY domain|compound|END_ENTITY	Identification of non-phosphate-containing small molecular weight inhibitors of the tyrosine kinase p56 Lck SH2 domain via in silico screening against the pY + 3 binding site .
15237112	0	tyrosine	109,117	Lck	105,108	tyrosine	Lck	CHEBI:18186	3932	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Evidence for a dual pathway of activation in CD43-stimulated Th2 cells : differential requirement for the Lck tyrosine kinase .
15337788	3	tyrosine	322,330	Lck	481,484	tyrosine	Tip	CHEBI:18186	261726	Chemical	Gene	protein|amod|START_ENTITY present|nsubj|protein present|nmod|kinase kinase|compound|END_ENTITY	The tyrosine kinase-interacting protein -LRB- Tip -RRB- of the T lymphotropic Herpesvirus_saimiri _ -LRB- HVS -RRB- is constitutively present in lipid rafts and interacts with cellular Lck tyrosine kinase and p80 endosomal protein .
15337788	3	tyrosine	485,493	Lck	481,484	tyrosine	Tip	CHEBI:18186	261726	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	The tyrosine kinase-interacting protein -LRB- Tip -RRB- of the T lymphotropic Herpesvirus_saimiri _ -LRB- HVS -RRB- is constitutively present in lipid rafts and interacts with cellular Lck tyrosine kinase and p80 endosomal protein .
15687496	0	tyrosine	49,57	Lck	87,90	tyrosine	Lck	CHEBI:18186	3932	Chemical	Gene	domain|compound|START_ENTITY lacking|dobj|domain CD45|acl|lacking Expression|nmod|CD45 modulates|nsubj|Expression modulates|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Expression of CD45 lacking the catalytic protein tyrosine phosphatase domain modulates Lck phosphorylation and T cell activation .
16154907	0	tyrosine	45,53	Lck	41,44	tyrosine	Lck	CHEBI:18186	3932	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|expression expression|nmod|END_ENTITY	Regulation of expression and function of Lck tyrosine kinase by high cell density .
16828835	0	tyrosine	91,99	Lck	87,90	tyrosine	Lck	CHEBI:18186	313050(Tax:10116)	Chemical	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	HIV-1 transgenic rat CD4 + T cells develop decreased CD28 responsiveness and suboptimal Lck tyrosine dephosphorylation following activation .
17078813	0	tyrosine	24,32	Lck	117,120	tyrosine	Lck	CHEBI:18186	3932	Chemical	Gene	phosphorylation|amod|START_ENTITY requires|nsubj|phosphorylation requires|dobj|END_ENTITY	Cr -LRB- VI -RRB- - stimulated STAT3 tyrosine phosphorylation and nuclear translocation in human airway epithelial cells requires Lck .
17100647	0	tyrosine	20,28	Lck	37,40	tyrosine	Lck	CHEBI:18186	3932	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	Expression of human tyrosine kinase , Lck , in yeast Saccharomyces_cerevisiae : growth suppression and strategy for inhibitor screening .
17277109	0	tyrosine	40,48	Lck	75,78	tyrosine	Lck	CHEBI:18186	16818(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY Changes|nmod|role phosphatase|nsubj|Changes phosphatase|advcl|regulating regulating|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Changes in the role of the CD45 protein tyrosine phosphatase in regulating Lck tyrosine phosphorylation during thymic development .
17277109	0	tyrosine	79,87	Lck	75,78	tyrosine	Lck	CHEBI:18186	16818(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|compound|END_ENTITY	Changes in the role of the CD45 protein tyrosine phosphatase in regulating Lck tyrosine phosphorylation during thymic development .
17507376	1	tyrosine	160,168	Lck	243,246	tyrosine	PTP	CHEBI:18186	19273(Tax:10090)	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|acl|expressed expressed|advcl|regulates regulates|dobj|activity activity|nmod|END_ENTITY	CD45 is a major membrane protein tyrosine phosphatase -LRB- PTP -RRB- expressed in T cells where it regulates the activity of Lck , a Src family kinase important for T cell receptor-mediated activation .
18321037	1	tyrosine	283,291	Lck	235,238	tyrosine	Lck	CHEBI:18186	3932	Chemical	Gene	kinases|compound|START_ENTITY family|nmod|kinases member|nmod|family lymphocyte-specific_kinase|appos|member lymphocyte-specific_kinase|appos|END_ENTITY	The lymphocyte-specific_kinase -LRB- Lck -RRB- , a member of the Src family of cytoplasmic tyrosine kinases , is expressed in T cells and natural killer -LRB- NK -RRB- cells .
20126650	0	tyrosine	17,25	Lck	34,37	tyrosine	Lck	CHEBI:18186	16818(Tax:10090)	Chemical	Gene	Roles|nmod|START_ENTITY kinases|nsubj|Roles kinases|dobj|END_ENTITY	Roles of the Src tyrosine kinases Lck and Fyn in regulating gammadeltaTCR signal strength .
24231767	0	tyrosine	38,46	Lck	54,57	tyrosine	Lck	CHEBI:18186	3932	Chemical	Gene	T-cells|amod|START_ENTITY T-cells|compound|END_ENTITY	GM1 controlled lateral segregation of tyrosine kinase Lck predispose T-cells to cell-derived galectin-1-induced apoptosis .
27014263	5	tyrosine	1025,1033	Lck	992,995	tyrosine	Lck	D014443	3932	Chemical	Gene	192|amod|START_ENTITY phosphorylated|nmod|192 promoted|advcl|phosphorylated promoted|dobj|diffusion diffusion|nmod|END_ENTITY	We further observed that the adaptor TSAd bound to and promoted the diffusion of Lck when it is phosphorylated on tyrosine 192 .
7486706	0	tyrosine	86,94	Lck	33,36	tyrosine	Lck	CHEBI:18186	3932	Chemical	Gene	autophosphorylation|amod|START_ENTITY site|nmod|autophosphorylation requires|dobj|site requires|nsubj|function function|nmod|END_ENTITY	The kinase-dependent function of Lck in T-cell activation requires an intact site for tyrosine autophosphorylation .
7512222	0	tyrosine	54,62	Lck	70,73	tyrosine	Lck	CHEBI:18186	3932	Chemical	Gene	domains|nmod|START_ENTITY Structure|nmod|domains kinase|nsubj|Structure kinase|dobj|END_ENTITY	Structure of the regulatory domains of the Src-family tyrosine kinase Lck .
7513706	0	tyrosine	59,67	Lck	39,42	tyrosine	Lck	CHEBI:18186	3932	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Distinct intracellular localization of Lck and Fyn protein tyrosine kinases in human T lymphocytes .
7538674	0	tyrosine	22,30	Lck	18,21	tyrosine	Lck	CHEBI:18186	3932	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Activation of the Lck tyrosine protein kinase by hydrogen_peroxide requires the phosphorylation of Tyr-394 .
7962172	0	tyrosine	70,78	Lck	86,89	tyrosine	Lck	CHEBI:18186	3932	Chemical	Gene	form|nmod|START_ENTITY Purification|nmod|form kinase|nsubj|Purification kinase|dobj|END_ENTITY	Purification and characterization of an activated form of the protein tyrosine kinase Lck from an Escherichia_coli expression system .
8524258	0	tyrosine	91,99	Lck	87,90	tyrosine	Lck	CHEBI:18186	3932	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Palmitoylation of either Cys-3 or Cys-5 is required for the biological activity of the Lck tyrosine protein kinase .
8631775	0	tyrosine	157,165	Lck	150,153	tyrosine	Lck	CHEBI:18186	3932	Chemical	Gene	394|amod|START_ENTITY mediated|nmod|394 mediated|nmod|autophosphorylation autophosphorylation|nmod|END_ENTITY	Detection of a physical and functional interaction between Csk and Lck which involves the SH2 domain of Csk and is mediated by autophosphorylation of Lck on tyrosine 394 .
8642247	0	tyrosine	18,26	Lck	0,3	tyrosine	Lck	CHEBI:18186	16818(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY regulates|dobj|phosphorylation regulates|nsubj|END_ENTITY	Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes .
8756658	0	tyrosine	70,78	Lck	23,26	tyrosine	Lck	CHEBI:18186	16818(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY role|nmod|phosphorylation analysis|dep|role analysis|nmod|END_ENTITY	Mutational analysis of Lck in CD45-negative T cells : dominant role of tyrosine 394 phosphorylation in kinase activity .
8798676	0	tyrosine	46,54	Lck	91,94	tyrosine	Lck	CHEBI:18186	3932	Chemical	Gene	site|nmod|START_ENTITY Identification|nmod|site kinase|nsubj|Identification kinase|ccomp|binds binds|dobj|domain domain|nmod|END_ENTITY	Identification of the site in the Syk protein tyrosine kinase that binds the SH2 domain of Lck .
8798764	0	tyrosine	36,44	Lck	18,21	tyrosine	Lck	CHEBI:18186	3932	Chemical	Gene	phosphorylation|amod|START_ENTITY Regulation|nmod|phosphorylation Regulation|nmod|domain domain|compound|END_ENTITY	Regulation of the Lck SH2 domain by tyrosine phosphorylation .
8798782	0	tyrosine	56,64	Lck	12,15	tyrosine	Lck	CHEBI:18186	3932	Chemical	Gene	phosphorylation|compound|START_ENTITY domains|nmod|phosphorylation domains|nsubj|Role Role|nmod|Src Src|compound|END_ENTITY	Role of the Lck Src homology 2 and 3 domains in protein tyrosine phosphorylation .
8858916	0	tyrosine	8,16	Lck	4,7	tyrosine	Lck	CHEBI:18186	16818(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The Lck tyrosine kinase is expressed in brain neurons .
8945479	0	tyrosine	68,76	Lck	59,62	tyrosine	Lck	CHEBI:18186	3932	Chemical	Gene	phosphorylation|amod|START_ENTITY kinase|nmod|phosphorylation kinase|dobj|END_ENTITY	Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation .
8986721	0	tyrosine	106,114	Lck	26,29	tyrosine	Lck	CHEBI:18186	3932	Chemical	Gene	activation|amod|START_ENTITY inhibits|dobj|activation inhibits|nsubj|involvement involvement|nmod|END_ENTITY	Sequential involvement of Lck and SHP-1 with MHC-recognizing receptors on NK cells inhibits FcR-initiated tyrosine kinase activation .
9278318	0	tyrosine	90,98	Lck	4,7	tyrosine	Lck	CHEBI:18186	3932	Chemical	Gene	phosphorylation|amod|START_ENTITY critical|nmod|phosphorylation critical|nsubj|site site|compound|END_ENTITY	The Lck SH2 phosphotyrosine binding site is critical for efficient TCR-induced processive tyrosine phosphorylation of the zeta-chain and IL-2 production .
9312162	0	tyrosine	39,47	Lck	0,3	tyrosine	Lck	CHEBI:18186	3932	Chemical	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity .
9325251	0	tyrosine	30,38	Lck	26,29	tyrosine	Lck	CHEBI:18186	3932	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	The activated form of the Lck tyrosine protein kinase in cells exposed to hydrogen_peroxide is phosphorylated at both Tyr-394 and Tyr-505 .
9390686	0	tyrosine	22,30	Lck	18,21	tyrosine	Lck	CHEBI:18186	3932	Chemical	Gene	cell|amod|START_ENTITY cell|compound|END_ENTITY	Activation of the Lck tyrosine kinase targets cell surface T cell antigen receptors for lysosomal degradation .
9548458	0	tyrosine	102,110	Lck	90,93	tyrosine	Lck	CHEBI:18186	16818(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Constitutive activation of the Janus kinase-STAT pathway in T_lymphoma overexpressing the Lck protein tyrosine kinase .
9558397	0	tyrosine	34,42	Lck	50,53	tyrosine	Lck	CHEBI:18186	3932	Chemical	Gene	Expression|nmod|START_ENTITY kinase|nsubj|Expression kinase|dobj|END_ENTITY	Expression of the T-cell-specific tyrosine kinase Lck in normal B-1 cells and in chronic_lymphocytic_leukemia B cells .
9566904	0	tyrosine	111,119	Lck	31,34	tyrosine	Lck	CHEBI:18186	3932	Chemical	Gene	function|nmod|START_ENTITY END_ENTITY|nmod|function	Genetic evidence of a role for Lck in T-cell receptor function independent or downstream of ZAP-70 / Syk protein tyrosine kinases .
9573028	0	tyrosine	59,67	Lck	76,79	tyrosine	Lck	CHEBI:18186	3932	Chemical	Gene	associates|nmod|START_ENTITY kinases|nsubj|associates kinases|dobj|END_ENTITY	CD44 selectively associates with active Src family protein tyrosine kinases Lck and Fyn in glycosphingolipid-rich plasma membrane domains of human peripheral blood lymphocytes .
9705913	0	tyrosine	74,82	Lck	90,93	tyrosine	Lck	CHEBI:18186	3932	Chemical	Gene	domain|amod|START_ENTITY domain|compound|END_ENTITY	The human_immunodeficiency_virus_type_1 Nef protein binds the Src-related tyrosine kinase Lck SH2 domain through a novel phosphotyrosine independent mechanism .
9710204	0	tyrosine	29,37	Lck	9,12	tyrosine	Lck	CHEBI:18186	3932	Chemical	Gene	START_ENTITY|nsubj|Roles Roles|nmod|END_ENTITY	Roles of Lck , Syk and ZAP-70 tyrosine kinases in TCR-mediated phosphorylation of the adapter protein Shc .
9973453	0	tyrosine	23,31	Lck	63,66	tyrosine	Lck	CHEBI:18186	16818(Tax:10090)	Chemical	Gene	phosphatase|compound|START_ENTITY inhibitor|nsubj|phosphatase inhibitor|nmod|activity activity|compound|END_ENTITY	Cutting edge : the CD45 tyrosine phosphatase is an inhibitor of Lck activity in thymocytes .
11416024	0	tyrosine	50,58	Leptin	0,6	tyrosine	Leptin	CHEBI:18186	25608(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY induce|dobj|phosphorylation induce|nsubj|END_ENTITY	Leptin and tumor_necrosis_factor-alpha induce the tyrosine phosphorylation of signal transducer and activator of transcription proteins in the hypothalamus of normal rats in vivo .
11997181	0	tyrosine	20,28	Leptin	0,6	tyrosine	Leptin	CHEBI:18186	3952	Chemical	Gene	phosphorylation|amod|START_ENTITY promotes|dobj|phosphorylation promotes|nsubj|END_ENTITY	Leptin promotes the tyrosine phosphorylation of SHC proteins and SHC association with GRB2 .
8941366	0	tyrosine	15,23	Leptin	0,6	tyrosine	Leptin	CHEBI:18186	3952	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Leptin induces tyrosine phosphorylation of cellular proteins including STAT-1 in human renal_adenocarcinoma cells , ACHN .
7964512	0	tyrosine	38,46	Lsk	22,25	tyrosine	Lsk	CHEBI:18186	4145	Chemical	Gene	kinase|compound|START_ENTITY END_ENTITY|appos|kinase	IL-4 and IL-13 induce Lsk , a Csk-like tyrosine kinase , in human monocytes .
8995435	0	tyrosine	26,34	Ltk	22,25	tyrosine	Ltk	CHEBI:18186	17005(Tax:10090)	Chemical	Gene	isoform|compound|START_ENTITY isoform|amod|END_ENTITY	A lymphocyte-specific Ltk tyrosine kinase isoform is retained in the endoplasmic reticulum in association with calnexin .
10672044	0	tyrosine	19,27	Lyn	15,18	tyrosine	Lyn	CHEBI:18186	17096(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Association Association|nmod|END_ENTITY	Association of Lyn tyrosine kinase to the GM-CSF and IL-3 receptor common betac subunit and role of Src tyrosine kinases in DNA synthesis and anti-apoptosis .
10891478	0	tyrosine	13,21	Lyn	9,12	tyrosine	Lyn	CHEBI:18186	4067	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role for Lyn tyrosine kinase as a regulator of stress-activated_protein_kinase activity in response to DNA damage .
11042209	0	tyrosine	26,34	Lyn	78,81	tyrosine	Lyn	CHEBI:18186	17096(Tax:10090)	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	The SH2 domain containing tyrosine phosphatase-1 down-regulates activation of Lyn and Lyn-induced tyrosine phosphorylation of the CD19 receptor in B cells .
11053250	0	tyrosine	12,20	Lyn	0,3	tyrosine	Lyn	CHEBI:18186	4067	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Lyn and syk tyrosine kinases are not activated in B-lineage lymphoid cells exposed to low-energy electromagnetic fields .
11823534	0	tyrosine	4,12	Lyn	0,3	tyrosine	Lyn	CHEBI:18186	17096(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Lyn tyrosine kinase is important for IL-5-stimulated eosinophil differentiation .
12486102	0	tyrosine	28,36	Lyn	24,27	tyrosine	Lyn	CHEBI:18186	17096(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Sustained activation of Lyn tyrosine kinase in vivo leads to autoimmunity .
12642697	0	tyrosine	4,12	Lyn	0,3	tyrosine	Lyn	CHEBI:18186	4067	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Lyn tyrosine kinase inhibits nuclear export of the p53 tumor suppressor .
12874221	0	tyrosine	8,16	Lyn	4,7	tyrosine	Lyn	CHEBI:18186	17096(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The Lyn tyrosine kinase negatively regulates neutrophil integrin signaling .
14726379	0	tyrosine	4,12	Lyn	0,3	tyrosine	Lyn	CHEBI:18186	17096(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Lyn tyrosine kinase regulates thrombopoietin-induced proliferation of hematopoietic cell lines and primary megakaryocytic progenitors .
15048725	0	tyrosine	109,117	Lyn	87,90	tyrosine	Lyn	CHEBI:18186	17096(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|compound|END_ENTITY	Positive and negative regulation of Fc_epsilon_receptor_I-mediated signaling events by Lyn kinase C-terminal tyrosine phosphorylation .
15650771	0	tyrosine	59,67	Lyn	55,58	tyrosine	Lyn	CHEBI:18186	4067	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Chronic_lymphocytic_leukemia B cells contain anomalous Lyn tyrosine kinase , a putative contribution to defective apoptosis .
16116174	0	tyrosine	8,16	Lyn	4,7	tyrosine	Lyn	CHEBI:18186	17096(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The Lyn tyrosine kinase differentially regulates dendritic cell generation and maturation .
16527271	0	tyrosine	36,44	Lyn	32,35	tyrosine	Lyn	CHEBI:18186	4067	Chemical	Gene	START_ENTITY|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of Golgi-associated Lyn tyrosine kinase in the translocation of annexin_II to the endoplasmic reticulum under oxidative stress .
17052693	0	tyrosine	45,53	Lyn	33,36	tyrosine	Lyn	CHEBI:18186	4067	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The association between CD36 and Lyn protein tyrosine kinase is mediated by lipid .
17918263	0	tyrosine	4,12	Lyn	0,3	tyrosine	Lyn	CHEBI:18186	17096(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Lyn tyrosine kinase is required for P2X -LRB- 4 -RRB- receptor upregulation and neuropathic_pain after peripheral nerve_injury .
18235045	0	tyrosine	31,39	Lyn	0,3	tyrosine	Lyn	CHEBI:18186	4067	Chemical	Gene	regulates|ccomp|START_ENTITY regulates|nsubj|END_ENTITY	Lyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib-resistant chronic_myelogenous_leukemia cells .
18817770	0	tyrosine	28,36	Lyn	24,27	tyrosine	Lyn	CHEBI:18186	4067	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Nuclear localization of Lyn tyrosine kinase mediated by inhibition of its kinase activity .
22364282	0	tyrosine	14,22	Lyn	10,13	tyrosine	Lyn	CHEBI:18186	4067	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Targeting Lyn tyrosine kinase through protein fusions encompassing motifs of Cbp -LRB- Csk-binding_protein -RRB- and the SOCS box of SOCS1 .
22777522	0	tyrosine	81,89	Lyn	77,80	tyrosine	Lyn	CHEBI:18186	4067	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Phosphatidylinositol-3_kinase activity in B cells is negatively regulated by Lyn tyrosine kinase .
23522727	0	tyrosine	47,55	Lyn	43,46	tyrosine	Lyn	CHEBI:18186	4067	Chemical	Gene	START_ENTITY|nsubj|identification identification|nmod|END_ENTITY	Molecular identification and expression of Lyn tyrosine kinase isoforms in marsupials .
24440445	3	tyrosine	512,520	Lyn	540,543	tyrosine	Lyn	D014443	17096(Tax:10090)	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Under normal signaling conditions the tyrosine kinase activity of Lyn is controlled by phosphorylation , primarily of two well known canonical regulatory tyrosine sites , Y-397 and Y-508 .
24891319	0	tyrosine	105,113	Lyn	101,104	tyrosine	Lyn	CHEBI:18186	17096(Tax:10090)	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Macrophage_migration_inhibitory_factor down-regulates the RANKL-RANK signaling pathway by activating Lyn tyrosine kinase in mouse models .
25104351	0	tyrosine	18,26	Lyn	14,17	tyrosine	Lyn	CHEBI:18186	17096(Tax:10090)	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Activation of Lyn tyrosine kinase through decreased membrane cholesterol levels during a change in its membrane distribution upon cell detachment .
25133482	0	tyrosine	4,12	Lyn	0,3	tyrosine	Lyn	CHEBI:18186	4067	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Lyn tyrosine kinase regulates androgen_receptor expression and activity in castrate-resistant prostate_cancer .
25173936	0	tyrosine	4,12	Lyn	0,3	tyrosine	Lyn	CHEBI:18186	4067	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Lyn tyrosine kinase promotes silencing of ATM-dependent checkpoint signaling during recovery from DNA double-strand breaks .
7499277	0	tyrosine	28,36	Lyn	24,27	tyrosine	Lyn	CHEBI:18186	4067	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|END_ENTITY	Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells .
7513431	0	tyrosine	4,12	Lyn	0,3	tyrosine	Lyn	CHEBI:18186	4067	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Lyn tyrosine kinase signals cell cycle arrest but not apoptosis in B-lineage lymphoma cells .
7594458	0	tyrosine	113,121	Lyn	101,104	tyrosine	Lyn	CHEBI:18186	4067	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Phosphorylated immunoreceptor signaling motifs -LRB- ITAMs -RRB- exhibit unique abilities to bind and activate Lyn and Syk tyrosine kinases .
7613138	0	tyrosine	62,70	Lyn	49,52	tyrosine	Lyn	CHEBI:18186	4067	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	The interleukin-5 / receptor interaction activates Lyn and Jak2 tyrosine kinases and propagates signals via the Ras-Raf-1-MAP kinase and the Jak-STAT pathways in eosinophils .
7636265	0	tyrosine	32,40	Lyn	20,23	tyrosine	Lyn	CHEBI:18186	4067	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Association between Lyn protein tyrosine kinase -LRB- p53/56lyn -RRB- and the beta subunit of the granulocyte-macrophage colony-stimulating factor -LRB- GM-CSF -RRB- receptors in a GM-CSF-dependent human megakaryocytic_leukemia cell line -LRB- M-07e -RRB- .
8001675	0	tyrosine	63,71	Lyn	59,62	tyrosine	Lyn	CHEBI:18186	4067	Chemical	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	N-acetyl-L-cysteine inhibits antigen-mediated Syk , but not Lyn tyrosine kinase activation in mast cells .
8612602	0	tyrosine	19,27	Lyn	15,18	tyrosine	Lyn	CHEBI:18186	4067	Chemical	Gene	START_ENTITY|nsubj|Association Association|nmod|END_ENTITY	Association of Lyn tyrosine kinase with the nuclear matrix and cell-cycle-dependent changes in matrix-associated tyrosine kinase activity .
8666899	0	tyrosine	27,35	Lyn	15,18	tyrosine	Lyn	CHEBI:18186	4067	Chemical	Gene	START_ENTITY|nsubj|Requirement Requirement|nmod|END_ENTITY	Requirement of Lyn and Syk tyrosine kinases for the prevention of apoptosis by cytokines in human eosinophils .
9083038	1	tyrosine	110,118	Lyn	106,109	tyrosine	Lyn	CHEBI:18186	4067	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The activation of Lyn tyrosine kinase and the mitogen-activated protein kinase pathway .
9130706	0	tyrosine	4,12	Lyn	0,3	tyrosine	Lyn	CHEBI:18186	4067	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Lyn tyrosine kinase is essential for erythropoietin-induced differentiation of J2E erythroid cells .
9171348	0	tyrosine	92,100	Lyn	88,91	tyrosine	Lyn	CHEBI:18186	4067	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Translocation of the Csk_homologous_kinase -LRB- Chk/Hyl -RRB- controls activity of CD36-anchored Lyn tyrosine kinase in thrombin-stimulated platelets .
9368072	0	tyrosine	26,34	Lyn	42,45	tyrosine	Lyn	CHEBI:18186	81515(Tax:10116)	Chemical	Gene	Association|nmod|START_ENTITY kinase|nsubj|Association kinase|dobj|END_ENTITY	Association of Src family tyrosine kinase Lyn with ganglioside_GD3 in rat brain .
9477973	0	tyrosine	39,47	Lyn	35,38	tyrosine	Lyn	CHEBI:18186	4067	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Spontaneous autophosphorylation of Lyn tyrosine kinase at both its activation segment and C-terminal tail confers altered substrate specificity .
9545346	0	tyrosine	87,95	Lyn	83,86	tyrosine	Lyn	CHEBI:18186	17096(Tax:10090)	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Overexpression of C-terminal_Src_kinase homologous kinase suppresses activation of Lyn tyrosine kinase required for VLA5-mediated Dami cell spreading .
9657978	0	tyrosine	19,27	Lyn	7,10	tyrosine	Lyn	CHEBI:18186	4067	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Active Lyn protein tyrosine kinase is selectively enriched within membrane microdomains of resting platelets .
9748231	0	tyrosine	54,62	Lyn	50,53	tyrosine	Lyn	CHEBI:18186	4067	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Regulation of DNA-dependent_protein_kinase by the Lyn tyrosine kinase .
10068674	0	tyrosine	77,85	Lyp	99,102	tyrosine	Lyp	CHEBI:18186	26191	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|appos|END_ENTITY	Cloning and characterization of a lymphoid-specific , inducible human protein tyrosine phosphatase , Lyp .
11882361	0	tyrosine	21,29	Lyp	42,45	tyrosine	Lyp	CHEBI:18186	26191	Chemical	Gene	START_ENTITY|dobj|interacts interacts|compound|END_ENTITY	The lymphoid protein tyrosine phosphatase Lyp interacts with the adaptor molecule Grb2 and functions as a negative regulator of T-cell activation .
21190368	1	tyrosine	88,96	Lyp	110,113	tyrosine	TCR	CHEBI:18186	6962	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|appos|END_ENTITY	The lymphoid tyrosine phosphatase -LRB- Lyp , PTPN22 -RRB- is a critical negative regulator of T_cell_antigen_receptor -LRB- TCR -RRB- signaling .
22952725	0	tyrosine	56,64	Lyp	78,81	tyrosine	Lyp	CHEBI:18186	26191	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|appos|END_ENTITY	Biochemical and functional studies of lymphoid-specific tyrosine phosphatase -LRB- Lyp -RRB- variants S201F and R266W .
24188455	0	tyrosine	18,26	Lyp	40,43	tyrosine	Lyp	CHEBI:18186	26191	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|appos|END_ENTITY	Lymphoid-specific tyrosine phosphatase -LRB- Lyp -RRB- : a potential drug target for treatment of autoimmune_diseases .
18378004	0	tyrosine	29,37	M-CSF	14,19	tyrosine	M-CSF	CHEBI:18186	1435	Chemical	Gene	START_ENTITY|nsubj|receptor receptor|compound|END_ENTITY	The selective M-CSF receptor tyrosine kinase inhibitor Ki20227 suppresses experimental autoimmune encephalomyelitis .
15601262	0	tyrosine	27,35	MEKK4	55,60	tyrosine	MEKK4	CHEBI:18186	4216	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Interferon-gamma-dependent tyrosine phosphorylation of MEKK4 via Pyk2 is regulated by annexin_II and SHP2 in keratinocytes .
21347448	0	tyrosine	30,38	MERTK	46,51	tyrosine	MERTK	CHEBI:18186	10461	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Polymorphisms in the receptor tyrosine kinase MERTK gene are associated with multiple_sclerosis susceptibility .
23585477	0	tyrosine	15,23	MERTK	0,5	tyrosine	MERTK	CHEBI:18186	10461	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	MERTK receptor tyrosine kinase is a therapeutic target in melanoma .
25074939	0	tyrosine	33,41	MERTK	18,23	tyrosine	MERTK	CHEBI:18186	10461	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Overexpression of MERTK receptor tyrosine kinase in epithelial cancer cells drives efferocytosis in a gain-of-function capacity .
26283020	0	tyrosine	64,72	MERTK	0,5	tyrosine	MERTK	D014443	65037(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY alpha|nsubj|phosphorylation regulates|xcomp|alpha regulates|nsubj|END_ENTITY	MERTK signaling in the retinal_pigment_epithelium regulates the tyrosine phosphorylation of GDP dissociation inhibitor alpha from the GDI/CHM family of RAB GTPase effectors .
17224082	0	tyrosine	15,23	MIXL1	49,54	tyrosine	MIXL1	CHEBI:18186	83881	Chemical	Gene	START_ENTITY|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Amino terminal tyrosine phosphorylation of human MIXL1 .
9418248	3	tyrosine	541,549	MKP-1	524,529	tyrosine	MKP-1	CHEBI:18186	19252(Tax:10090)	Chemical	Gene	phosphatase|compound|START_ENTITY END_ENTITY|appos|phosphatase	The expression of the MAP kinase phosphatase MKP-1 , a protein tyrosine phosphatase , is induced upon infection , and phagocytosis of L. _ monocytogenes by J774 cells overexpressing the MKP-1 protein is reduced compared to control cells .
21219825	0	tyrosine	15,23	MMP-2	58,63	tyrosine	MMP-2	CHEBI:18186	4313	Chemical	Gene	START_ENTITY|nmod|secretion secretion|nmod|END_ENTITY	-LSB- Effect of Src tyrosine kinase inhibition on secretion of MMP-2 and MMP-9 by non-small cell lung_cancer cells -RSB- .
21249321	0	tyrosine	66,74	MMP-2	19,24	tyrosine	MMP-2	CHEBI:18186	4313	Chemical	Gene	inhibition|nmod|START_ENTITY due|nmod|inhibition expression|amod|due expression|compound|END_ENTITY	Down-regulation of MMP-2 expression due to inhibition of receptor tyrosine kinases by imatinib and carboplatin in HNSCC .
7490087	5	tyrosine	760,768	MPTP-PEST	716,725	tyrosine	MPTP-PEST	CHEBI:18186	19255(Tax:10090)	Chemical	Gene	phosphatases|compound|START_ENTITY phosphatases|amod|END_ENTITY	Detailed comparison of the position of intron/exon boundaries of the phosphatase domain of MPTP-PEST to those of several other protein tyrosine phosphatases indicates that the MPTP-PEST catalytic domain contains additional exons as a consequence of the insertion of novel introns .
15652236	0	tyrosine	33,41	MRP1	54,58	tyrosine	MRP1	CHEBI:18186	4363	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	Role of two adjacent cytoplasmic tyrosine residues in MRP1 -LRB- ABCC1 -RRB- transport activity and sensitivity to sulfonylureas .
14734766	0	tyrosine	98,106	Macrophage-stimulating_protein	0,30	tyrosine	Macrophage-stimulating protein	CHEBI:18186	15235(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY END_ENTITY|appos|kinase	Macrophage-stimulating_protein , the ligand for the stem cell-derived tyrosine kinase/RON receptor tyrosine kinase , inhibits IL-12 production by primary peritoneal macrophages stimulated with IFN-gamma and lipopolysaccharide .
8695717	0	tyrosine	70,78	Macrophage-stimulating_protein	0,30	tyrosine	Macrophage-stimulating protein	CHEBI:18186	4485	Chemical	Gene	kinase|compound|START_ENTITY END_ENTITY|appos|kinase	Macrophage-stimulating_protein , a ligand for the RON receptor protein tyrosine kinase , suppresses myeloid progenitor cell proliferation and synergizes with vascular endothelial cell growth factor and members of the chemokine family .
15985438	0	tyrosine	20,28	Mdm2	48,52	tyrosine	Mdm2	CHEBI:18186	4193	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Secretase-dependent tyrosine phosphorylation of Mdm2 by the ErbB-4 intracellular_domain fragment .
10092806	0	tyrosine	17,25	Mer	34,37	tyrosine	Mer	CHEBI:18186	17289(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	A novel receptor tyrosine kinase , Mer , inhibits TNF-alpha production and lipopolysaccharide-induced endotoxic_shock .
11929866	0	tyrosine	13,21	Mer	0,3	tyrosine	Mer	CHEBI:18186	17289(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Mer receptor tyrosine kinase signaling : prevention of apoptosis and alteration of cytoskeletal architecture without stimulation or proliferation .
18039660	0	tyrosine	57,65	Mer	44,47	tyrosine	Mer	CHEBI:18186	10461	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Autophosphorylation docking site Tyr-867 in Mer receptor tyrosine kinase allows for dissociation of multiple signaling pathways for phagocytosis of apoptotic cells and down-modulation of lipopolysaccharide-inducible NF-kappaB transcriptional activation .
19541935	0	tyrosine	46,54	Mer	33,36	tyrosine	Mer	CHEBI:18186	10461	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Up-regulation of soluble Axl and Mer receptor tyrosine kinases negatively correlates with Gas6 in established multiple_sclerosis_lesions .
20822883	0	tyrosine	23,31	Mer	10,13	tyrosine	Mer	CHEBI:18186	17289(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|receptor receptor|compound|END_ENTITY	Disrupted Mer receptor tyrosine kinase expression leads to enhanced MZ B-cell responses .
22427680	0	tyrosine	24,32	Mer	11,14	tyrosine	Mer	CHEBI:18186	17289(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Inhibiting Mer receptor tyrosine kinase suppresses STAT1 , SOCS1/3 , and NF-kB activation and enhances inflammatory responses in lipopolysaccharide-induced acute_lung_injury .
14704368	0	tyrosine	13,21	MerTK	29,34	tyrosine	MerTK	CHEBI:18186	17289(Tax:10090)	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|ccomp|activates activates|nsubj|END_ENTITY	The receptor tyrosine kinase MerTK activates phospholipase_C_gamma2 during recognition of apoptotic thymocytes by murine macrophages .
19301199	0	tyrosine	13,21	MerTK	29,34	tyrosine	MerTK	CHEBI:18186	17289(Tax:10090)	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|ccomp|regulates regulates|nsubj|END_ENTITY	The receptor tyrosine kinase MerTK regulates dendritic cell production of BAFF .
19386698	0	tyrosine	4,12	MerTK	21,26	tyrosine	MerTK	CHEBI:18186	17289(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	Mer tyrosine kinase -LRB- MerTK -RRB- promotes macrophage survival following exposure to oxidative stress .
20978472	4	tyrosine	470,478	MerTK	525,530	tyrosine	Tulp1	CHEBI:18186	7287	Chemical	Gene	interacts|nmod|START_ENTITY kinase|nsubj|interacts kinase|advcl|binds binds|nmod|END_ENTITY	Tulp1 interacts with Tyro3 , Axl and MerTK of the TAM receptor tyrosine kinase subfamily , whereas tubby binds only to MerTK .
21192804	2	tyrosine	545,553	MerTK	499,504	tyrosine	MerTK	CHEBI:18186	17289(Tax:10090)	Chemical	Gene	kinases|compound|START_ENTITY termed|nsubj|kinases termed|advcl|using using|dobj|deficient deficient|nmod|END_ENTITY	We investigated AC clearance , also termed efferocytosis , during post-lactational remodeling , using mice deficient for MerTK , Axl , and Tyro3 , three related receptor tyrosine kinases -LRB- RTKs -RRB- regulating macrophage-mediated efferocytosis in monocytes .
18511575	0	tyrosine	66,74	Mertk	82,87	tyrosine	Mertk	CHEBI:18186	17289(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY signals|nmod|kinase END_ENTITY|nsubj|signals	The scavenger receptor SR-A I/II -LRB- CD204 -RRB- signals via the receptor tyrosine kinase Mertk during apoptotic cell uptake by murine macrophages .
24768065	0	tyrosine	19,27	Mertk	4,9	tyrosine	Mertk	CHEBI:18186	17289(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The Mertk receptor tyrosine kinase promotes T-B interaction stimulated by IgD B-cell receptor cross-linking .
16638745	0	tyrosine	21,29	Munc18c	49,56	tyrosine	Munc18c	CHEBI:18186	6814	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	The stimulus-induced tyrosine phosphorylation of Munc18c facilitates vesicle exocytosis .
18541526	0	tyrosine	4,12	Munc18c	32,39	tyrosine	Munc18c	CHEBI:18186	6814	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	The tyrosine phosphorylation of Munc18c induces a switch in binding specificity from syntaxin_4 to Doc2beta .
23937695	0	tyrosine	52,60	Munc18c	44,51	tyrosine	Munc18c	CHEBI:18186	6814	Chemical	Gene	phosphorylation|amod|START_ENTITY END_ENTITY|dobj|phosphorylation	Regulation of the SNARE-interacting protein Munc18c tyrosine phosphorylation in adipocytes by protein-tyrosine_phosphatase_1B .
26210580	0	tyrosine	20,28	N-cadherin	53,63	tyrosine	N-cadherin	D014443	1000	Chemical	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	Vitamin_D regulates tyrosine hydroxylase expression : N-cadherin a possible mediator .
9786960	0	tyrosine	24,32	N-cadherin	86,96	tyrosine	N-cadherin	CHEBI:18186	1000	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	The nonreceptor protein tyrosine phosphatase PTP1B binds to the cytoplasmic domain of N-cadherin and regulates the cadherin-actin linkage .
12932824	0	tyrosine	57,65	N-methyl-D-aspartate_receptor_subunit_2A	16,56	tyrosine	N-methyl-D-aspartate receptor subunit 2A	CHEBI:18186	24409(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Lithium reduced N-methyl-D-aspartate_receptor_subunit_2A tyrosine phosphorylation and its interactions with Src and Fyn mediated by PSD-95 in rat hippocampus following cerebral_ischemia .
19096031	0	tyrosine	137,145	NADPH_oxidase_2	177,192	tyrosine	NADPH oxidase 2	CHEBI:18186	13058(Tax:10090)	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Macrophages generate reactive oxygen species in response to minimally oxidized low-density lipoprotein : toll-like receptor 4 - and spleen tyrosine kinase-dependent activation of NADPH_oxidase_2 .
10580107	0	tyrosine	99,107	NF-kappaB	172,181	tyrosine	NF-kappaB	CHEBI:18186	4790	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Human_immunodeficiency_virus-1-tat induces matrix_metalloproteinase-9 in monocytes through protein tyrosine phosphatase-mediated activation of nuclear transcription factor NF-kappaB .
12909638	0	tyrosine	70,78	NF-kappaB	56,65	tyrosine	NF-kappaB	CHEBI:18186	4790	Chemical	Gene	phosphorylation|amod|START_ENTITY END_ENTITY|nmod|phosphorylation	Hepatitis_C virus NS5A and subgenomic replicon activate NF-kappaB via tyrosine phosphorylation of IkappaBalpha and its degradation by calpain protease .
18471101	0	tyrosine	78,86	NF-kappaB	64,73	tyrosine	NF-kappaB	CHEBI:18186	4790	Chemical	Gene	kinase|amod|START_ENTITY END_ENTITY|nmod|kinase	Aquatic birnavirus infection activates the transcription factor NF-kappaB via tyrosine kinase signalling leading to cell death .
12711606	0	tyrosine	47,55	NF-kappa_B	28,38	tyrosine	NF-kappa B	CHEBI:18186	4790	Chemical	Gene	phosphorylation|amod|START_ENTITY END_ENTITY|nmod|phosphorylation	Hydrogen_peroxide activates NF-kappa_B through tyrosine phosphorylation of I_kappa_B_alpha and serine phosphorylation of p65 : evidence for the involvement of I_kappa_B_alpha kinase and Syk protein-tyrosine kinase .
1320413	0	tyrosine	36,44	NGF_receptor	23,35	tyrosine	NGF receptor	CHEBI:18186	24596(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|inhibition inhibition|nmod|END_ENTITY	Specific inhibition of NGF_receptor tyrosine kinase activity by K-252a .
19834457	0	tyrosine	23,31	NMDAR2A	15,22	tyrosine	NMDAR2A	CHEBI:18186	14811(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of NMDAR2A tyrosine phosphorylation in depression-related behaviour .
16899073	0	tyrosine	22,30	NMDA_receptor	8,21	tyrosine	NMDA receptor	CHEBI:18186	14810(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Reduced NMDA_receptor tyrosine phosphorylation in PTPalpha-deficient mouse synaptosomes is accompanied by inhibition of four src family kinases and Pyk2 : an upstream role for PTPalpha in NMDA_receptor regulation .
17367757	0	tyrosine	22,30	NOK	46,49	tyrosine	NOK	CHEBI:18186	243659(Tax:10090)	Chemical	Gene	residue|compound|START_ENTITY residue|nmod|END_ENTITY	The carboxyl terminal tyrosine 417 residue of NOK has an autoinhibitory effect on NOK-mediated signaling transductions .
21338238	0	tyrosine	9,17	NPM1	53,57	tyrosine	NPM1	CHEBI:18186	4869	Chemical	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	Fms like tyrosine kinase -LRB- FLT3 -RRB- and nucleophosmin_1 -LRB- NPM1 -RRB- mutations in de novo normal karyotype acute_myeloid_leukemia -LRB- AML -RRB- .
14503841	0	tyrosine	19,27	NR2A	51,55	tyrosine	NR2A	CHEBI:18186	24409(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Relative extent of tyrosine phosphorylation of the NR2A and NR2B subunits in the rat forebrain postsynaptic density fraction .
15755673	0	tyrosine	100,108	NR2A	95,99	tyrosine	NR2A	CHEBI:18186	24409(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Repetitive_febrile_seizures in rat pups cause long-lasting_deficits in synaptic plasticity and NR2A tyrosine phosphorylation .
18022328	0	tyrosine	82,90	NR2A	110,114	tyrosine	NR2A	CHEBI:18186	24409(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Activation of GABA receptors attenuates neuronal apoptosis through inhibiting the tyrosine phosphorylation of NR2A by Src after cerebral_ischemia and reperfusion .
9085267	0	tyrosine	56,64	NR2A	84,88	tyrosine	NR2A	CHEBI:18186	24409(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Developmental expression , subcellular localization , and tyrosine phosphorylation of NR2A and NR2B in the rat brain .
9892651	0	tyrosine	29,37	NR2A	99,103	tyrosine	NR2A	CHEBI:18186	2903	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit NR2A .
11841566	0	tyrosine	154,162	NR2B	149,153	tyrosine	NR2B	CHEBI:18186	24410(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Lithium protection against glutamate excitotoxicity in rat cerebral cortical neurons : involvement of NMDA receptor inhibition possibly by decreasing NR2B tyrosine phosphorylation .
16710293	0	tyrosine	5,13	NR2B	0,4	tyrosine	NR2B	CHEBI:18186	14812(Tax:10090)	Chemical	Gene	modulates|compound|START_ENTITY modulates|compound|END_ENTITY	NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity .
17625058	0	tyrosine	73,81	NR2B	101,105	tyrosine	NR2B	CHEBI:18186	24410(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	PREGS induces LTP in the hippocampal dentate gyrus of adult rats via the tyrosine phosphorylation of NR2B coupled to ERK/CREB -LSB- corrected -RSB- signaling .
18694808	0	tyrosine	17,25	NR2B	45,49	tyrosine	NR2B	CHEBI:18186	24410(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	EphrinB2 induces tyrosine phosphorylation of NR2B via Src-family kinases during inflammatory hyperalgesia .
19864302	0	tyrosine	94,102	NR2B	122,126	tyrosine	NR2B	CHEBI:18186	2904	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Endogenous ephrinB2 mediates colon-urethra cross-organ sensitization via Src kinase-dependent tyrosine phosphorylation of NR2B .
21055728	0	tyrosine	43,51	NR2B	71,75	tyrosine	NR2B	CHEBI:18186	14812(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Cyclic_adenosine_monophosphate-independent tyrosine phosphorylation of NR2B mediates cocaine-induced extracellular_signal-regulated_kinase activation .
21147838	0	tyrosine	77,85	NR2B	105,109	tyrosine	NR2B	CHEBI:18186	24410(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	EphrinB2 induces pelvic-urethra reflex potentiation via Src kinase-dependent tyrosine phosphorylation of NR2B .
25100942	0	tyrosine	17,25	NR2B	45,49	tyrosine	NR2B	CHEBI:18186	14812(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Dopamine-induced tyrosine phosphorylation of NR2B -LRB- Tyr1472 -RRB- is essential for ERK1/2 activation and processing of novel taste information .
26303340	0	tyrosine	45,53	NR2B	73,77	tyrosine	NR2B	D014443	24410(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Adenosine A2A receptors permit mGluR5-evoked tyrosine phosphorylation of NR2B -LRB- Tyr1472 -RRB- in rat hippocampus : a possible key mechanism in NMDA receptor modulation .
25936889	2	tyrosine	322,330	NSCLC	351,356	tyrosine	c-MET	D014443	4233	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|nmod|END_ENTITY	HGF/c-MET plays the pivotal role in the growth , development and tolerance to epidermal_growth_factor_receptor tyrosine kinase inhibitor of NSCLC .
21708027	0	tyrosine	35,43	NTRK1	29,34	tyrosine	NTRK1	CHEBI:18186	4914	Chemical	Gene	domain|amod|START_ENTITY domain|compound|END_ENTITY	A short in-frame deletion in NTRK1 tyrosine kinase domain caused by a novel splice site mutation in a patient with congenital_insensitivity to pain with anhidrosis .
7789988	0	tyrosine	56,64	NTRK2	87,92	tyrosine	NTRK2	CHEBI:18186	4915	Chemical	Gene	START_ENTITY|dobj|gene gene|appos|END_ENTITY	Cloning and chromosomal localization of the human TRK-B tyrosine kinase receptor gene -LRB- NTRK2 -RRB- .
21357692	0	tyrosine	38,46	Nephrocystin-4	0,14	tyrosine	Nephrocystin-4	CHEBI:18186	261734	Chemical	Gene	phosphorylation|compound|START_ENTITY regulates|dobj|phosphorylation regulates|nsubj|END_ENTITY	Nephrocystin-4 regulates Pyk2-induced tyrosine phosphorylation of nephrocystin-1 to control targeting to monocilia .
1400471	0	tyrosine	35,43	Nerve_growth_factor	0,19	tyrosine	Nerve growth factor	CHEBI:18186	310738(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Nerve_growth_factor stimulates the tyrosine phosphorylation of a 38-kDa protein that specifically associates with the src homology domain of phospholipase_C-gamma_1 .
8631760	0	tyrosine	35,43	Nerve_growth_factor	0,19	tyrosine	Nerve growth factor	CHEBI:18186	310738(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Nerve_growth_factor stimulates the tyrosine phosphorylation of endogenous Crk-II and augments its association with p130Cas in PC-12 cells .
11314013	0	tyrosine	9,17	Neu	127,130	tyrosine	Neu	CHEBI:18186	2064	Chemical	Gene	START_ENTITY|ccomp|mediate mediate|nmod|receptor receptor|compound|END_ENTITY	Distinct tyrosine autophosphorylation sites mediate induction of epithelial mesenchymal like transition by an activated ErbB-2 / Neu receptor .
9405068	0	tyrosine	40,48	Neuromedin_B_receptor	0,21	tyrosine	Neuromedin B receptor	CHEBI:18186	25264(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY causes|dobj|phosphorylation causes|nsubj|activation activation|compound|END_ENTITY	Neuromedin_B_receptor activation causes tyrosine phosphorylation of p125FAK by a phospholipase C independent mechanism which requires p21rho and integrity of the actin cytoskeleton .
1354339	0	tyrosine	22,30	Neurotensin	0,11	tyrosine	Neurotensin	CHEBI:18186	299757(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|increases increases|compound|END_ENTITY	Neurotensin increases tyrosine hydroxylase messenger RNA-positive neurons in substantia nigra after retrograde axonal transport .
8134103	0	tyrosine	39,47	Nuk	26,29	tyrosine	Nuk	CHEBI:18186	13844(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Immunolocalization of the Nuk receptor tyrosine kinase suggests roles in segmental patterning of the brain and axonogenesis .
19609305	0	tyrosine	62,70	Numb	0,4	tyrosine	Numb	CHEBI:18186	8650	Chemical	Gene	regulates|advcl|START_ENTITY regulates|nsubj|END_ENTITY	Numb regulates cell-cell adhesion and polarity in response to tyrosine kinase signalling .
24398510	0	tyrosine	25,33	OATP1B1	14,21	tyrosine	OATP1B1	CHEBI:18186	10599	Chemical	Gene	inhibitors|amod|START_ENTITY Inhibition|nmod|inhibitors Inhibition|nmod|END_ENTITY	Inhibition of OATP1B1 by tyrosine kinase inhibitors : in vitro-in vivo correlations .
8603605	0	tyrosine	69,77	OST-PTP	91,98	tyrosine	OST-PTP	CHEBI:18186	64576(Tax:10116)	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|appos|END_ENTITY	Parathyroid_hormone regulates the expression of the receptor protein tyrosine phosphatase , OST-PTP , in rat osteoblast-like cells .
1324279	0	tyrosine	21,29	Oncostatin_M	0,12	tyrosine	Oncostatin M	CHEBI:18186	5008	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Oncostatin_M induces tyrosine phosphorylation in endothelial cells and activation of p62yes tyrosine kinase .
17585854	0	tyrosine	5,13	P2X7_receptor	100,113	tyrosine	P2X7 receptor	CHEBI:18186	5027	Chemical	Gene	activity|nmod|START_ENTITY activity|nmod|END_ENTITY	From tyrosine to glycine : synthesis and biological activity of potent antagonists of the purinergic P2X7_receptor .
17999916	0	tyrosine	57,65	P2X7_receptor	24,37	tyrosine	P2X7 receptor	CHEBI:18186	5027	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of the human P2X7_receptor by a novel protein tyrosine kinase antagonist .
15886804	0	tyrosine	29,37	P2Y12	0,5	tyrosine	P2Y12	CHEBI:18186	64805	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	P2Y12 ADP receptor-dependent tyrosine phosphorylation of proteins of 27 and 31 kDa in thrombin-stimulated human platelets .
9233759	0	tyrosine	24,32	P53	0,3	tyrosine	P53	CHEBI:18186	301300(Tax:10116)	Chemical	Gene	associates|nmod|START_ENTITY associates|nummod|END_ENTITY	P53 associates with trk tyrosine kinase .
7981618	0	tyrosine	37,45	P56lck	0,6	tyrosine	P56lck	CHEBI:18186	3932	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|advmod|END_ENTITY	P56lck A lymphocyte specific protein tyrosine kinase : activation , regulation and signal transduction .
21220489	0	tyrosine	10,18	PCNA	38,42	tyrosine	PCNA	CHEBI:18186	5111	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Targeting tyrosine phosphorylation of PCNA inhibits prostate_cancer growth .
23542172	0	tyrosine	87,95	PCNA	115,119	tyrosine	PCNA	CHEBI:18186	5111	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	The Ron receptor tyrosine kinase activates c-Abl to promote cell proliferation through tyrosine phosphorylation of PCNA in breast_cancer .
12501215	0	tyrosine	66,74	PCP-2	87,92	tyrosine	PCP-2	CHEBI:18186	126006	Chemical	Gene	interaction|nmod|START_ENTITY phosphatase|nsubj|interaction phosphatase|xcomp|END_ENTITY	Physical and functional interaction between receptor-like protein tyrosine phosphatase PCP-2 and beta-catenin .
15986889	0	tyrosine	48,56	PCP-2	69,74	tyrosine	PCP-2	CHEBI:18186	126006	Chemical	Gene	interaction|nmod|START_ENTITY basis|nmod|interaction phosphatase|nsubj|basis phosphatase|xcomp|END_ENTITY	Structural basis of interaction between protein tyrosine phosphatase PCP-2 and beta-catenin .
8700514	0	tyrosine	52,60	PCP-2	20,25	tyrosine	PCP-2	CHEBI:18186	126006	Chemical	Gene	START_ENTITY|nsubj|Characterization Characterization|nmod|END_ENTITY	Characterization of PCP-2 , a novel receptor protein tyrosine phosphatase of the MAM domain family .
10893303	0	tyrosine	188,196	PDGF-Rbeta	177,187	tyrosine	PDGF-Rbeta	CHEBI:18186	5159	Chemical	Gene	kinases|compound|START_ENTITY kinases|amod|END_ENTITY	Identification of substituted 3 - -LSB- -LRB- 4,5,6 , _ 7-tetrahydro-1H-indol-2-yl -RRB- methylene -RSB- -1,3 - dihydroindol-2-ones as growth factor receptor inhibitors for VEGF-R2 -LRB- Flk-1 / KDR -RRB- , FGF-R1 , and PDGF-Rbeta tyrosine kinases .
23901112	0	tyrosine	91,99	PDGF-b	75,81	tyrosine	PDGF-b	CHEBI:18186	5155	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Selective activation of oxidized PTP1B by the thioredoxin system modulates PDGF-b receptor tyrosine kinase signaling .
16763682	0	tyrosine	122,130	PDGFR	116,121	tyrosine	PDGFR	CHEBI:18186	5159	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|compound|END_ENTITY	Structure-activity studies on a library of potent calix -LSB- 4 -RSB- arene-based PDGF antagonists that inhibit PDGF-stimulated PDGFR tyrosine phosphorylation .
17983688	0	tyrosine	20,28	PDGFR	14,19	tyrosine	PDGFR	CHEBI:18186	5159	Chemical	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Inhibition of PDGFR tyrosine kinase activity by a series of novel N - -LRB- 3 - -LRB- 4 - -LRB- pyridin-3-yl -RRB- -1 H-imidazol-2-ylamino -RRB- phenyl -RRB- amides : a SAR study on the bioisosterism of pyrimidine and imidazole .
7479761	2	tyrosine	1018,1026	PDGFR	1050,1055	tyrosine	IL-4R	CHEBI:18186	16190(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	We found that stimulation of 3T3-L1 adipocytes with PDGF resulted in tyrosine phosphorylation of the PDGFR and activation of PI3-kinase in these cells .
7980524	0	tyrosine	16,24	PDGFR	10,15	tyrosine	PDGFR	CHEBI:18186	5159	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The alpha PDGFR tyrosine kinase mediates locomotion of two different cell types through chemotaxis and chemokinesis .
18343900	0	tyrosine	119,127	PDGFRalpha	108,118	tyrosine	PDGFRalpha	CHEBI:18186	5156	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	A quantitative structure-activity relationship study of novel , potent , orally active , selective VEGFR-2 and PDGFRalpha tyrosine kinase inhibitors : derivatives of N-phenyl-N ' - -LCB- 4 - -LRB- 4-quinolyloxy -RRB- phenyl -RCB- urea as antitumor agents .
20543524	0	tyrosine	108,116	PDGF_receptor_b	92,107	tyrosine	PDGF receptor b	CHEBI:18186	24629(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|compound|END_ENTITY	Gambogic_acid induces G0/G1 cell cycle arrest and cell migration inhibition via suppressing PDGF_receptor_b tyrosine phosphorylation and Rac1 activity in rat aortic smooth muscle cells .
18559349	0	tyrosine	44,52	PDK-1	72,77	tyrosine	PDK-1	CHEBI:18186	228026(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Nox4 NAD -LRB- P -RRB- H oxidase mediates Src-dependent tyrosine phosphorylation of PDK-1 in response to angiotensin_II : role in mesangial cell hypertrophy and fibronectin expression .
14585963	0	tyrosine	24,32	PDK1	52,56	tyrosine	PDK1	CHEBI:18186	5163	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Pyk2 - and Src-dependent tyrosine phosphorylation of PDK1 regulates focal adhesions .
18024423	0	tyrosine	83,91	PDK1	111,115	tyrosine	PDK1	CHEBI:18186	5163	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Regulation of 3-phosphoinositide-dependent_protein_kinase-1 -LRB- PDK1 -RRB- by Src involves tyrosine phosphorylation of PDK1 and Src homology 2 domain binding .
20534451	3	tyrosine	357,365	PEAK1	326,331	tyrosine	PEAK1	CHEBI:18186	79834	Chemical	Gene	kinase|compound|START_ENTITY kinase|nsubj|END_ENTITY	PEAK1 is a 190-kDa nonreceptor tyrosine kinase that localizes to actin filaments and focal adhesions .
9148965	0	tyrosine	61,69	PECAM-1	118,125	tyrosine	PECAM-1	CHEBI:18186	29583(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Aggregation of the high affinity IgE receptor results in the tyrosine phosphorylation of the surface adhesion protein PECAM-1 -LRB- CD31 -RRB- .
9624175	0	tyrosine	28,36	PECAM-1	20,27	tyrosine	PECAM-1	CHEBI:18186	18613(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of mouse PECAM-1 tyrosine phosphorylation by the Src and Csk families of protein-tyrosine kinases .
17998206	0	tyrosine	78,86	PERK	70,74	tyrosine	PERK	CHEBI:18186	9451	Chemical	Gene	phosphorylation|amod|START_ENTITY END_ENTITY|nmod|phosphorylation	Modulation of the eukaryotic initiation factor 2 alpha-subunit kinase PERK by tyrosine phosphorylation .
15247276	0	tyrosine	91,99	PHAPI	163,168	tyrosine	PHAPI	CHEBI:18186	8125	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	Protein phosphatase 2A , a negative regulator of the ERK signaling pathway , is activated by tyrosine phosphorylation of putative HLA class II-associated protein I -LRB- PHAPI -RRB- / pp32 in response to the antiproliferative lectin , jacalin .
19277985	0	tyrosine	50,58	PHLPP1	90,96	tyrosine	PHLPP1	CHEBI:18186	23239	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Insulin_receptor kinase-independent signaling via tyrosine phosphorylation of phosphatase PHLPP1 .
11716513	0	tyrosine	11,19	PKC_delta	39,48	tyrosine	PKC delta	CHEBI:18186	5580	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	UV-induced tyrosine phosphorylation of PKC_delta and promotion of apoptosis in the HaCaT cell line .
15811957	0	tyrosine	69,77	PKCdelta	97,105	tyrosine	PKCdelta	CHEBI:18186	5580	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Molecular mechanism and functional implications of thrombin-mediated tyrosine phosphorylation of PKCdelta in platelets .
17943181	0	tyrosine	18,26	PKCdelta	9,17	tyrosine	PKCdelta	CHEBI:18186	5580	Chemical	Gene	residues|compound|START_ENTITY residues|compound|END_ENTITY	Multiple PKCdelta tyrosine residues are required for PKCdelta-dependent activation of involucrin expression -- a key role of PKCdelta-Y311 .
9825917	0	tyrosine	51,59	PKCdelta	79,87	tyrosine	PKCdelta	CHEBI:18186	170538(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Involvement of protein kinases and phosphatases in tyrosine phosphorylation of PKCdelta in rat parotid acinar cells exposed to secretory stimuli .
19920249	0	tyrosine	5,13	PKM2	0,4	tyrosine	PKM2	CHEBI:18186	5315	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|compound|END_ENTITY	PKM2 tyrosine phosphorylation and glutamine metabolism signal a different view of the Warburg effect .
17290288	0	tyrosine	19,27	PKR	68,71	tyrosine	PKR	CHEBI:18186	5610	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Interferons induce tyrosine phosphorylation of the eIF2alpha kinase PKR through activation of Jak1 and Tyk2 .
23236554	0	tyrosine	68,76	PKR	96,99	tyrosine	PKR	CHEBI:18186	5610	Chemical	Gene	START_ENTITY|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	JAK kinases are required for the bacterial RNA and poly I : C induced tyrosine phosphorylation of PKR .
26321373	0	tyrosine	27,35	PKR	55,58	tyrosine	PKR	D014443	5610	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Insulin treatment promotes tyrosine phosphorylation of PKR and inhibits polyIC induced PKR threonine phosphorylation .
8125925	7	tyrosine	1430,1438	PLC-gamma_1	1458,1469	tyrosine	PLC-gamma 1	CHEBI:18186	25738(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Taken together , the present studies indicate that EGF-induced tyrosine phosphorylation of PLC-gamma_1 , its association with the cytoskeleton , and its interaction with activated Gi alpha protein are all obligatory for PLC-gamma_1 activation in hepatocytes .
9125218	0	tyrosine	61,69	PLC-gamma_1	111,122	tyrosine	PLC-gamma 1	CHEBI:18186	25738(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Role of intracellular calcium in the angiotensin_II-mediated tyrosine phosphorylation and dephosphorylation of PLC-gamma_1 .
7689859	0	tyrosine	46,54	PLC-gamma_2	74,85	tyrosine	PLC-gamma 2	CHEBI:18186	5336	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Thrombin activation of human platelets causes tyrosine phosphorylation of PLC-gamma_2 .
1336638	0	tyrosine	35,43	PLC_gamma_1	63,74	tyrosine	PLC gamma 1	CHEBI:18186	5335	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	CD28 receptor crosslinking induces tyrosine phosphorylation of PLC_gamma_1 .
15879121	0	tyrosine	6,14	PLC_gamma_1	39,50	tyrosine	PLC gamma 1	CHEBI:18186	5335	Chemical	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	A new tyrosine phosphorylation site in PLC_gamma_1 : the role of tyrosine 775 in immune receptor signaling .
7532179	0	tyrosine	49,57	PLC_gamma_1	37,48	tyrosine	PLC gamma 1	CHEBI:18186	25738(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|END_ENTITY	Cell density-dependent regulation of PLC_gamma_1 tyrosine phosphorylation and catalytic activity in an intestinal cell line -LRB- IEC-6 -RRB- .
9606958	0	tyrosine	92,100	PLC_gamma_2	149,160	tyrosine	PLC gamma 2	CHEBI:18186	5336	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Convulxin induces platelet activation by a tyrosine-kinase-dependent pathway and stimulates tyrosine phosphorylation of platelet proteins , including PLC_gamma_2 , independently of integrin alpha IIb beta 3 .
14994199	0	tyrosine	86,94	PLCgamma2	114,123	tyrosine	PLCgamma2	CHEBI:18186	5336	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Tanshinones inhibit mast cell degranulation by interfering with IgE receptor-mediated tyrosine phosphorylation of PLCgamma2 and MAPK .
9295022	0	tyrosine	21,29	PP1	48,51	tyrosine	PP1	CHEBI:18186	29471(Tax:10116)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Src family-selective tyrosine kinase inhibitor , PP1 , inhibits both Fc epsilonRI - and Thy-1-mediated activation of rat basophilic_leukemia cells .
21775053	0	tyrosine	74,82	PP2	109,112	tyrosine	PP2	CHEBI:18186	18169(Tax:10090)	Chemical	Gene	kinase|amod|START_ENTITY END_ENTITY|amod|kinase	Suppression of autophagy sensitizes multidrug resistant cells towards Src tyrosine kinase specific inhibitor PP2 .
24449710	8	tyrosine	1326,1334	PPO	1301,1304	tyrosine	PPO	CHEBI:18186	5498	Chemical	Gene	metabolism|nmod|START_ENTITY END_ENTITY|nmod|metabolism	Several observed metabolic changes point to a direct role for PPO in the metabolism of tyrosine and in the biosynthesis of the hydroxycoumarin esculetin in vivo .
17234774	0	tyrosine	6,14	PRL-1	0,5	tyrosine	PRL-1	CHEBI:18186	7803	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|compound|END_ENTITY	PRL-1 tyrosine phosphatase regulates c-Src levels , adherence , and invasion in human lung_cancer cells .
8196618	0	tyrosine	32,40	PRL-1	0,5	tyrosine	PRL-1	CHEBI:18186	29463(Tax:10116)	Chemical	Gene	phosphatase|compound|START_ENTITY END_ENTITY|appos|phosphatase	PRL-1 , a unique nuclear protein tyrosine phosphatase , affects cell growth .
8529999	0	tyrosine	158,166	PRL-1	152,157	tyrosine	PRL-1	CHEBI:18186	7803	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|compound|END_ENTITY	A 100-kb physical and transcriptional map around the EDH17B2 gene : identification of three novel genes and a pseudogene of a human homologue of the rat PRL-1 tyrosine phosphatase .
24632616	0	tyrosine	12,20	PRL-2	33,38	tyrosine	PRL-2	CHEBI:18186	8073	Chemical	Gene	START_ENTITY|dobj|interacts interacts|compound|END_ENTITY	The protein tyrosine phosphatase PRL-2 interacts with the magnesium transporter CNNM3 to promote oncogenesis .
11355880	0	tyrosine	39,47	PRL-3	8,13	tyrosine	PRL-3	CHEBI:18186	11156	Chemical	Gene	phosphatase|compound|START_ENTITY END_ENTITY|appos|phosphatase	Role of PRL-3 , a human muscle-specific tyrosine phosphatase , in angiotensin-II signaling .
15133662	0	tyrosine	51,59	PRL-3	72,77	tyrosine	PRL-3	CHEBI:18186	11156	Chemical	Gene	START_ENTITY|dobj|protein protein|compound|END_ENTITY	The association of the expression level of protein tyrosine phosphatase PRL-3 protein with liver metastasis and prognosis of patients with colorectal_cancer .
22995644	0	tyrosine	19,27	PRL-3	41,46	tyrosine	PRL-3	CHEBI:18186	11156	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|appos|END_ENTITY	The pro-metastasis tyrosine phosphatase , PRL-3 -LRB- PTP4A3 -RRB- , is a novel mediator of oncogenic function of BCR-ABL in human chronic_myeloid_leukemia .
10085298	7	tyrosine	1222,1230	PSTPIP	1250,1256	tyrosine	PSTPIP	CHEBI:18186	9051	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	In -LRB- - / - -RRB- cells , we found a significant increase in the level of tyrosine phosphorylation of PSTPIP , a cleavage furrow-associated protein that interacts physically with all PEST family members .
9804817	0	tyrosine	19,27	PSTPIP_2	0,8	tyrosine	PSTPIP 2	CHEBI:18186	9050	Chemical	Gene	protein|amod|START_ENTITY END_ENTITY|appos|protein	PSTPIP_2 , a second tyrosine phosphorylated , cytoskeletal-associated protein that binds a PEST-type protein-tyrosine phosphatase .
8395005	0	tyrosine	23,31	PTC1	105,109	tyrosine	PTC1	CHEBI:18186	851558(Tax:4932)	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mutations in a protein tyrosine phosphatase gene -LRB- PTP2 -RRB- and a protein serine/threonine phosphatase gene -LRB- PTC1 -RRB- cause a synthetic growth defect in Saccharomyces_cerevisiae .
15017976	0	tyrosine	37,45	PTEN	20,24	tyrosine	PTEN	CHEBI:18186	5728	Chemical	Gene	phosphatases|compound|START_ENTITY phosphatases|compound|END_ENTITY	Redox regulation of PTEN and protein tyrosine phosphatases in H -LRB- 2 -RRB- O -LRB- 2 -RRB- mediated cell signaling .
19192961	0	tyrosine	39,47	PTEN	21,25	tyrosine	PTEN	CHEBI:18186	5728	Chemical	Gene	START_ENTITY|nsubj|Interactions Interactions|nmod|END_ENTITY	Interactions between PTEN and receptor tyrosine kinase pathways and their implications for glioma therapy .
20685300	0	tyrosine	45,53	PTEN	208,212	tyrosine	PTEN	CHEBI:18186	5728	Chemical	Gene	START_ENTITY|nmod|activities activities|nmod|END_ENTITY	Unique biochemical properties of the protein tyrosine phosphatase activity of PTEN-demonstration of different active site structural requirements for phosphopeptide and phospholipid phosphatase activities of PTEN .
24814346	0	tyrosine	18,26	PTEN	0,4	tyrosine	PTEN	D014443	5728	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|nsubj|END_ENTITY	PTEN is a protein tyrosine phosphatase for IRS1 .
9072974	0	tyrosine	25,33	PTEN	0,4	tyrosine	PTEN	CHEBI:18186	5728	Chemical	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	PTEN , a putative protein tyrosine phosphatase gene mutated in human brain , _ breast , _ and_prostate_cancer .
11257458	5	tyrosine	1101,1109	PTH	1129,1132	tyrosine	Src	CHEBI:18186	83805(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|-RSB- -RSB-|compound|END_ENTITY	Stimulation of PLCgamma tyrosine phosphorylation by PTH _ -LSB- 1-34 -RSB- greatly decreased with ageing .
14976243	0	tyrosine	37,45	PTK	54,57	tyrosine	PTK	CHEBI:18186	2185	Chemical	Gene	START_ENTITY|dobj|inhibitors inhibitors|appos|END_ENTITY	Combination of rapamycin and protein tyrosine kinase -LRB- PTK -RRB- inhibitors for the treatment of leukemias caused by oncogenic PTKs .
1572549	0	tyrosine	65,73	PTK	82,85	tyrosine	PTK	CHEBI:18186	2185	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	The genomic locus of the human hemopoietic-specific cell protein tyrosine kinase -LRB- PTK -RRB- - encoding gene -LRB- HCK -RRB- confirms conservation of exon-intron structure among human PTKs of the src family .
9733815	3	tyrosine	539,547	PTK	556,559	tyrosine	PTK	CHEBI:18186	2185	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	Association of Syk protein tyrosine kinase -LRB- PTK -RRB- with LMP2A occurs at the two tyrosines of the LMP2A immunoreceptor tyrosine-based activation motif , and it is hypothesized that Lyn PTK associates with the YEEA amino_acid motif at LMP2A tyrosine 112 -LRB- Y112 -RRB- .
16888096	1	tyrosine	306,314	PTP	328,331	tyrosine	SYK	CHEBI:18186	6850	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|appos|END_ENTITY	The strength and duration of B-cell-receptor -LRB- BCR -RRB- signaling depends upon the balance between protein tyrosine kinase -LRB- PTK -RRB- activation and protein tyrosine phosphatase -LRB- PTP -RRB- inhibition .
19167484	0	tyrosine	48,56	PTP	70,73	tyrosine	PTP	CHEBI:18186	10076	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|appos|END_ENTITY	Enhanced clonogenic survival induced by protein tyrosine phosphatase -LRB- PTP -RRB- inhibition after Cr -LRB- VI -RRB- exposure is mediated by c-Raf and Ras activity .
21251827	0	tyrosine	78,86	PTP	100,103	tyrosine	PTP	CHEBI:18186	10076	Chemical	Gene	START_ENTITY|dobj|inhibitors inhibitors|appos|END_ENTITY	A unique and rapid approach toward the efficient development of novel protein tyrosine phosphatase -LRB- PTP -RRB- inhibitors based on ` clicked ' pseudo-glycopeptides .
26911335	0	tyrosine	100,108	PTP	84,87	tyrosine	PTP	D014443	10076	Chemical	Gene	phosphatases|compound|START_ENTITY phosphatases|compound|END_ENTITY	Resveratrol attenuates constitutive STAT3 and STAT5 activation through induction of PTP and SHP-2 tyrosine phosphatases and potentiates sorafenib-induced apoptosis in renal_cell_carcinoma .
27026654	0	tyrosine	31,39	PTP	56,59	tyrosine	PTP	D014443	19280(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|phosphatase phosphatase|appos|END_ENTITY	Expression of receptor protein tyrosine phosphatase , PTP , in mouse central nervous system .
15928604	0	tyrosine	21,29	PTP-1B	43,49	tyrosine	PTP-1B	CHEBI:18186	5770	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|appos|END_ENTITY	-LSB- The role of protein tyrosine phosphatase -LRB- PTP-1B -RRB- in insulin resistance -RSB- .
11432829	0	tyrosine	29,37	PTP-PEST	0,8	tyrosine	PTP-PEST	CHEBI:18186	5782	Chemical	Gene	phosphatase|compound|START_ENTITY END_ENTITY|appos|phosphatase	PTP-PEST , a scaffold protein tyrosine phosphatase , negatively regulates lymphocyte activation by targeting a unique set of substrates .
10583472	0	tyrosine	41,49	PTP-SL	64,70	tyrosine	PTP-SL	CHEBI:18186	19279(Tax:10090)	Chemical	Gene	phosphatases|compound|START_ENTITY phosphatases|appos|END_ENTITY	The mouse Ptprr gene encodes two protein tyrosine phosphatases , PTP-SL and PTPBR7 , that display distinct patterns of expression during neural development .
10601328	0	tyrosine	112,120	PTP-SL	105,111	tyrosine	PTP-SL	CHEBI:18186	5801	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|amod|END_ENTITY	A novel regulatory mechanism of MAP kinases activation and nuclear translocation mediated by PKA and the PTP-SL tyrosine phosphatase .
9857190	0	tyrosine	24,32	PTP-SL	0,6	tyrosine	PTP-SL	CHEBI:18186	5801	Chemical	Gene	phosphatases|compound|START_ENTITY phosphatases|compound|END_ENTITY	PTP-SL and STEP protein tyrosine phosphatases regulate the activation of the extracellular signal-regulated kinases ERK1 and ERK2 by association through a kinase interaction motif .
11106648	0	tyrosine	10,18	PTP1B	93,98	tyrosine	PTP1B	CHEBI:18186	5770	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	Essential tyrosine residues for interaction of the non-receptor protein-tyrosine phosphatase PTP1B with N-cadherin .
18387954	0	tyrosine	26,34	PTP1B	0,5	tyrosine	PTP1B	CHEBI:18186	5770	Chemical	Gene	phosphorylation|compound|START_ENTITY regulates|dobj|phosphorylation regulates|nsubj|END_ENTITY	PTP1B regulates cortactin tyrosine phosphorylation by targeting Tyr446 .
20181825	0	tyrosine	12,20	PTP1B	33,38	tyrosine	PTP1B	CHEBI:18186	5770	Chemical	Gene	phosphatase|nsubj|START_ENTITY phosphatase|ccomp|required required|nsubjpass|END_ENTITY	The protein tyrosine phosphatase PTP1B is required for efficient delivery of N-cadherin to the cell surface .
22701734	0	tyrosine	17,25	PTP1B	38,43	tyrosine	PTP1B	CHEBI:18186	19246(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|interacts interacts|compound|END_ENTITY	ER-bound protein tyrosine phosphatase PTP1B interacts with Src at the plasma membrane/substrate interface .
23604820	0	tyrosine	78,86	PTP1B	100,105	tyrosine	PTP1B	CHEBI:18186	5770	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|appos|END_ENTITY	Kinetics and molecular docking studies of pimarane-type diterpenes as protein tyrosine phosphatase -LRB- PTP1B -RRB- inhibitors from Aralia continentalis roots .
7935344	0	tyrosine	34,42	PTP1B	56,61	tyrosine	PTP1B	CHEBI:18186	5770	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|appos|END_ENTITY	Serine phosphorylation of protein tyrosine phosphatase -LRB- PTP1B -RRB- in HeLa cells in response to analogues of cAMP or diacylglycerol plus okadaic_acid .
8491187	0	tyrosine	42,50	PTP1B	64,69	tyrosine	PTP1B	CHEBI:18186	5770	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|appos|END_ENTITY	Multi-site phosphorylation of the protein tyrosine phosphatase , PTP1B : identification of cell cycle regulated and phorbol_ester stimulated sites of phosphorylation .
7664792	0	tyrosine	133,141	PTP1C	127,132	tyrosine	PTP1C	CHEBI:18186	15170(Tax:10090)	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|compound|END_ENTITY	Antigen receptor-triggered apoptosis in immature B cell lines is associated with the binding of a 44-kDa phosphoprotein to the PTP1C tyrosine phosphatase .
8648092	0	tyrosine	81,89	PTP1C	57,62	tyrosine	PTP1C	CHEBI:18186	15170(Tax:10090)	Chemical	Gene	phosphatases|compound|START_ENTITY phosphatases|compound|END_ENTITY	Human and mouse killer-cell inhibitory receptors recruit PTP1C and PTP1D protein tyrosine phosphatases .
11594781	0	tyrosine	15,23	PTP1D	36,41	tyrosine	PTP1D	CHEBI:18186	5781	Chemical	Gene	Involvement|nmod|START_ENTITY phosphatase|nsubj|Involvement phosphatase|dobj|END_ENTITY	Involvement of tyrosine phosphatase PTP1D in the inhibition of interleukin-6-induced Stat3 signaling by alpha-thrombin .
10679022	0	tyrosine	31,39	PTP2	53,57	tyrosine	PTP2	CHEBI:18186	854383(Tax:4932)	Chemical	Gene	functions|nmod|START_ENTITY phosphatases|nsubj|functions phosphatases|dobj|END_ENTITY	Essential functions of protein tyrosine phosphatases PTP2 and PTP3 and RIM11 tyrosine phosphorylation in Saccharomyces_cerevisiae meiosis and sporulation .
10679022	4	tyrosine	652,660	PTP2	589,593	tyrosine	PTP2	CHEBI:18186	854383(Tax:4932)	Chemical	Gene	phosphorylation|amod|START_ENTITY involved|nsubjpass|phosphorylation suggesting|ccomp|involved report|advcl|suggesting report|dobj|deletion deletion|nmod|results results|compound|END_ENTITY	Here we report that deletion of PTP2 and PTP3 results in a sporulation defect , suggesting that tyrosine phosphorylation is involved in regulation of meiosis and sporulation .
1577774	0	tyrosine	51,59	PTP2	78,82	tyrosine	PTP2	CHEBI:18186	854383(Tax:4932)	Chemical	Gene	START_ENTITY|dobj|gene gene|appos|END_ENTITY	Isolation and characterization of a second protein tyrosine phosphatase gene , PTP2 , from Saccharomyces_cerevisiae .
8395005	0	tyrosine	23,31	PTP2	50,54	tyrosine	PTP2	CHEBI:18186	854383(Tax:4932)	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mutations in a protein tyrosine phosphatase gene -LRB- PTP2 -RRB- and a protein serine/threonine phosphatase gene -LRB- PTC1 -RRB- cause a synthetic growth defect in Saccharomyces_cerevisiae .
8601424	0	tyrosine	53,61	PTP2C	74,79	tyrosine	PTP2C	CHEBI:18186	5781	Chemical	Gene	role|nmod|START_ENTITY phosphatase|nsubj|role phosphatase|dobj|END_ENTITY	Localization and down-regulating role of the protein tyrosine phosphatase PTP2C in membrane ruffles of PDGF-stimulated cells .
9032256	0	tyrosine	110,118	PTP3	97,101	tyrosine	PTP3	CHEBI:18186	856807(Tax:4932)	Chemical	Gene	phosphatases|compound|START_ENTITY phosphatases|compound|END_ENTITY	Regulation of the Saccharomyces_cerevisiae HOG1 mitogen-activated protein kinase by the PTP2 and PTP3 protein tyrosine phosphatases .
22780963	0	tyrosine	33,41	PTP52F	54,60	tyrosine	PTP52F	CHEBI:18186	36790(Tax:7227)	Chemical	Gene	phosphatase|nsubj|START_ENTITY phosphatase|ccomp|required required|nsubjpass|END_ENTITY	Midgut-enriched receptor protein tyrosine phosphatase PTP52F is required for Drosophila development during larva-pupa transition .
15242314	0	tyrosine	31,39	PTPL1	1,6	tyrosine	PTPL1	CHEBI:18186	5783	Chemical	Gene	phosphatase|compound|START_ENTITY END_ENTITY|appos|phosphatase	-LSB- PTPL1 , a proapoptotic protein tyrosine phosphatase in breast_cancers -RSB- .
24465712	0	tyrosine	131,139	PTPN1	153,158	tyrosine	PTPN1	CHEBI:18186	5770	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|appos|END_ENTITY	pTyr421 cortactin is overexpressed in colon_cancer and is dephosphorylated by curcumin : involvement of non-receptor type 1 protein tyrosine phosphatase -LRB- PTPN1 -RRB- .
8824809	0	tyrosine	33,41	PTPN13	0,6	tyrosine	PTPN13	CHEBI:18186	5783	Chemical	Gene	phosphatase|compound|START_ENTITY END_ENTITY|appos|phosphatase	PTPN13 , a fas-associated protein tyrosine phosphatase , is located on the long arm of chromosome 4 at band q21 .3 .
15734872	0	tyrosine	39,47	PTPN22	61,67	tyrosine	PTPN22	CHEBI:18186	26191	Chemical	Gene	association|nmod|START_ENTITY phosphatase|nsubj|association phosphatase|dobj|END_ENTITY	Genetic association between a lymphoid tyrosine phosphatase -LRB- PTPN22 -RRB- and type 1 diabetes .
16164701	0	tyrosine	24,32	PTPN22	46,52	tyrosine	PTPN22	CHEBI:18186	26191	Chemical	Gene	phosphatase|amod|START_ENTITY study|nmod|phosphatase study|appos|END_ENTITY	A case-control study of tyrosine phosphatase -LRB- PTPN22 -RRB- confirms the lack of association with Crohn 's _ disease .
16470599	0	tyrosine	68,76	PTPN22	95,101	tyrosine	PTPN22	CHEBI:18186	26191	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Systematic search for single nucleotide polymorphisms in a lymphoid tyrosine phosphatase gene -LRB- PTPN22 -RRB- : association between a promoter polymorphism and type 1 diabetes in Asian populations .
16678435	0	tyrosine	18,26	PTPN22	45,51	tyrosine	PTPN22	CHEBI:18186	26191	Chemical	Gene	phosphatases|nsubj|START_ENTITY phosphatases|nmod|END_ENTITY	Are other protein tyrosine phosphatases than PTPN22 associated with autoimmunity ?
18056891	0	tyrosine	12,20	PTPN22	49,55	tyrosine	PTPN22	CHEBI:18186	26191	Chemical	Gene	phosphatase|nsubj|START_ENTITY phosphatase|ccomp|associated associated|nsubjpass|nonreceptor nonreceptor|appos|END_ENTITY	The protein tyrosine phosphatase nonreceptor 22 -LRB- PTPN22 -RRB- is associated with high GAD antibody titer in latent autoimmune_diabetes in adults : Non Insulin Requiring Autoimmune_Diabetes -LRB- NIRAD -RRB- Study 3 .
18710467	0	tyrosine	42,50	PTPN22	64,70	tyrosine	PTPN22	CHEBI:18186	26191	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The tryptophan 620 allele of the lymphoid tyrosine phosphatase -LRB- PTPN22 -RRB- gene predisposes to autoimmune Addison 's _ disease .
20538612	0	tyrosine	110,118	PTPN22	22,28	tyrosine	PTPN22	CHEBI:18186	26191	Chemical	Gene	residue|amod|START_ENTITY phosphatase|nmod|residue phosphorylation|nmod|phosphatase reduces|dobj|phosphorylation reduces|nsubj|variation variation|compound|END_ENTITY	Autoimmune-associated PTPN22 R620W variation reduces phosphorylation of lymphoid phosphatase on an inhibitory tyrosine residue .
24117662	0	tyrosine	54,62	PTPN22	85,91	tyrosine	PTPN22	CHEBI:18186	26191	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A novel single nucleotide polymorphism in the protein tyrosine phosphatase N22 gene -LRB- PTPN22 -RRB- is associated with Type 1 diabetes in a Chinese population .
24905474	0	tyrosine	12,20	PTPN22	33,39	tyrosine	PTPN22	CHEBI:18186	19260(Tax:10090)	Chemical	Gene	phosphatase|nsubj|START_ENTITY phosphatase|ccomp|controls controls|nsubj|END_ENTITY	The protein tyrosine phosphatase PTPN22 controls forkhead_box_protein_3 T regulatory cell induction but is dispensable for T helper type 1 cell polarization .
25715232	0	tyrosine	59,67	PTPN22	80,86	tyrosine	PTPN22	D014443	26191	Chemical	Gene	roles|nmod|START_ENTITY phosphatase|nsubj|roles phosphatase|dobj|END_ENTITY	Multifunctional roles of the autoimmune disease-associated tyrosine phosphatase PTPN22 in regulating T cell homeostasis .
25748328	0	tyrosine	20,28	PTPN22	41,47	tyrosine	PTPN22	CHEBI:18186	19260(Tax:10090)	Chemical	Gene	Lack|nmod|START_ENTITY phosphatase|nsubj|Lack phosphatase|ccomp|strengthens strengthens|nsubj|END_ENTITY	Lack of the protein tyrosine phosphatase PTPN22 strengthens transplant tolerance to pancreatic islets in mice .
27043286	0	tyrosine	6,14	PTPN22	77,83	tyrosine	PTPN22	D014443	26191	Chemical	Gene	phosphorylation|amod|START_ENTITY controlled|nsubjpass|phosphorylation controlled|nmod|END_ENTITY	NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22 .
17339465	0	tyrosine	84,92	PTPN3	70,75	tyrosine	PTPN3	CHEBI:18186	545622(Tax:10090)	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|compound|END_ENTITY	Normal TCR signal transduction in mice that lack catalytically active PTPN3 protein tyrosine phosphatase .
1639416	0	tyrosine	46,54	PTPN6	68,73	tyrosine	PTPN6	CHEBI:18186	5777	Chemical	Gene	phosphatase|amod|START_ENTITY phosphatase|appos|END_ENTITY	Chromosomal localization of an SH2-containing tyrosine phosphatase -LRB- PTPN6 -RRB- .
22759068	0	tyrosine	74,82	PTPRJ	65,70	tyrosine	PTPRJ	CHEBI:18186	5795	Chemical	Gene	receptor|amod|START_ENTITY END_ENTITY|appos|receptor	Isolation and functional characterization of peptide agonists of PTPRJ , a tyrosine phosphatase receptor endowed with tumor suppressor activity .
22815804	0	tyrosine	39,47	PTPRJ	72,77	tyrosine	PTPRJ	CHEBI:18186	5795	Chemical	Gene	Expression|nmod|START_ENTITY phosphatase|nsubj|Expression phosphatase|dobj|J J|appos|END_ENTITY	Expression and function of the protein tyrosine phosphatase receptor J -LRB- PTPRJ -RRB- in normal mammary epithelial cells and breast_tumors .
25772245	0	tyrosine	12,20	PTPRJ	39,44	tyrosine	PTPRJ	CHEBI:18186	5795	Chemical	Gene	phosphatase|nsubj|START_ENTITY phosphatase|ccomp|promotes promotes|nsubj|END_ENTITY	The protein tyrosine phosphatase DEP-1 / PTPRJ promotes breast_cancer cell invasion and metastasis .
8404049	0	tyrosine	48,56	PTPRM	75,80	tyrosine	PTPRM	CHEBI:18186	5797	Chemical	Gene	START_ENTITY|dobj|gene gene|appos|END_ENTITY	Fine mapping of the human receptor-like protein tyrosine phosphatase gene -LRB- PTPRM -RRB- to 18p11 .2 by fluorescence in situ hybridization .
14508512	0	tyrosine	27,35	PTPRO	70,75	tyrosine	PTPRO	CHEBI:18186	50677(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|gene gene|appos|END_ENTITY	Suppression of the protein tyrosine phosphatase receptor type O gene -LRB- PTPRO -RRB- by methylation in hepatocellular_carcinomas .
19137382	0	tyrosine	14,22	PTPRR	0,5	tyrosine	PTPRR	CHEBI:18186	19279(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|protein protein|amod|END_ENTITY	PTPRR protein tyrosine phosphatase isoforms and locomotion of vesicles and mice .
20133774	0	tyrosine	12,20	PTPRZ	34,39	tyrosine	PTPRZ	CHEBI:18186	19283(Tax:10090)	Chemical	Gene	phosphatases|nsubj|START_ENTITY phosphatases|xcomp|END_ENTITY	The protein tyrosine phosphatases PTPRZ and PTPRG bind to distinct members of the contactin family of neural recognition molecules .
10093970	0	tyrosine	70,78	PYK2	65,69	tyrosine	PYK2	CHEBI:18186	2185	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|compound|END_ENTITY	Suppression of protein_kinase_C is associated with inhibition of PYK2 tyrosine phosphorylation and enhancement of PYK2 interaction with Src in thrombin-activated platelets .
10797305	0	tyrosine	110,118	PYK2	105,109	tyrosine	PYK2	CHEBI:18186	2185	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Thrombin-stimulated phosphatidylinositol 3-kinase activity in platelets is associated with activation of PYK2 tyrosine kinase : activation of both enzymes is aggregation independent .
10964954	0	tyrosine	38,46	PYK2	66,70	tyrosine	PYK2	CHEBI:18186	50646(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Cerebral_ischemia and seizures induce tyrosine phosphorylation of PYK2 in neurons and microglial cells .
11394906	0	tyrosine	34,42	PYK2	61,65	tyrosine	PYK2	CHEBI:18186	2185	Chemical	Gene	phosphorylated|advmod|START_ENTITY phosphorylated|nmod|END_ENTITY	Glycogen_synthase_kinase_3beta is tyrosine phosphorylated by PYK2 .
11406493	0	tyrosine	14,22	PYK2	42,46	tyrosine	PYK2	CHEBI:18186	541008(Tax:9913)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Regulation of tyrosine phosphorylation of PYK2 in vascular endothelial cells by lysophosphatidylcholine .
15585656	0	tyrosine	73,81	PYK2	101,105	tyrosine	PYK2	CHEBI:18186	2185	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Ephrin-A1 binding to CD4 + T lymphocytes stimulates migration and induces tyrosine phosphorylation of PYK2 .
17684059	0	tyrosine	78,86	PYK2	106,110	tyrosine	PYK2	CHEBI:18186	50646(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Calcineurin is essential for depolarization-induced nuclear translocation and tyrosine phosphorylation of PYK2 in neurons .
17698736	0	tyrosine	34,42	PYK2	50,54	tyrosine	PYK2	CHEBI:18186	19229(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY kinase|nsubj|role kinase|dobj|END_ENTITY	Central role of calcium-dependent tyrosine kinase PYK2 in endothelial nitric_oxide synthase-mediated angiogenic response and vascular function .
11751924	8	tyrosine	1123,1131	PZR	1151,1154	tyrosine	PZR	CHEBI:18186	68481(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Expression of an intracellular domain-truncated form of PZR in HT-1080 cells affected cell morphology and had a dominant negative effect on ConA-induced tyrosine phosphorylation of PZR , activation of c-Src , and agglutination of the cells .
25915848	0	tyrosine	31,39	Paxillin	0,8	tyrosine	Paxillin	D014443	5829	Chemical	Gene	confers|advcl|START_ENTITY confers|nsubj|END_ENTITY	Paxillin confers resistance to tyrosine kinase inhibitors in EGFR-mutant lung_cancers via modulating BIM and Mcl-1 protein stability .
25915848	0	tyrosine	31,39	Paxillin	0,8	tyrosine	Paxillin	D014443	5829	Chemical	Gene	confers|advcl|START_ENTITY confers|nsubj|END_ENTITY	Paxillin confers resistance to tyrosine kinase inhibitors in EGFR-mutant lung_cancers via modulating BIM and Mcl-1 protein stability .
7540588	0	tyrosine	59,67	Pdgfra	88,94	tyrosine	Pdgfra	CHEBI:18186	18595(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|family family|dep|END_ENTITY	A 1.8-Mb YAC contig spanning three members of the receptor tyrosine kinase gene family -LRB- Pdgfra , Kit , and Flk1 -RRB- on mouse chromosome 5 .
15387363	0	tyrosine	24,32	Phospholipase_C	0,15	tyrosine	Phospholipase C	CHEBI:18186	100009319(Tax:9986)	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Phospholipase_C and src tyrosine kinases mediate neurotensin-stimulated Cl - secretion in rabbit proximal colon .
1901060	0	tyrosine	35,43	Platelet-activating_factor	0,26	tyrosine	Platelet-activating factor	CHEBI:18186	9768	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Platelet-activating_factor induces tyrosine phosphorylation in human neutrophils .
8583698	0	tyrosine	55,63	Platelet-activating_factor	0,26	tyrosine	Platelet-activating factor	CHEBI:18186	300795(Tax:10116)	Chemical	Gene	pathway|amod|START_ENTITY induces|nmod|pathway induces|nsubj|END_ENTITY	Platelet-activating_factor induces cell growth through tyrosine phosphorylation pathway in cultured rat mesangial cells .
20509775	0	tyrosine	40,48	Platelet-derived_growth_factor_receptor	0,39	tyrosine	Platelet-derived growth factor receptor	CHEBI:18186	5159	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Platelet-derived_growth_factor_receptor tyrosine kinase inhibitors : a review of the recent patent literature .
10706604	0	tyrosine	163,171	Pleiotrophin	0,12	tyrosine	Pleiotrophin	CHEBI:18186	5764	Chemical	Gene	beta/zeta|compound|START_ENTITY activity|nmod|beta/zeta inactivation|nmod|activity increased|nmod|inactivation increased|nsubj|signals signals|compound|END_ENTITY	Pleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase beta/zeta .
10706604	0	tyrosine	31,39	Pleiotrophin	0,12	tyrosine	Pleiotrophin	CHEBI:18186	5764	Chemical	Gene	phosphorylation|amod|START_ENTITY increased|dobj|phosphorylation increased|nsubj|signals signals|compound|END_ENTITY	Pleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase beta/zeta .
16105548	0	tyrosine	124,132	Pleiotrophin	0,12	tyrosine	Pleiotrophin	CHEBI:18186	5764	Chemical	Gene	beta/zeta|amod|START_ENTITY phosphorylation|nmod|beta/zeta stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Pleiotrophin stimulates tyrosine phosphorylation of beta-adducin through inactivation of the transmembrane receptor protein tyrosine phosphatase beta/zeta .
16105548	0	tyrosine	24,32	Pleiotrophin	0,12	tyrosine	Pleiotrophin	CHEBI:18186	5764	Chemical	Gene	phosphorylation|amod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Pleiotrophin stimulates tyrosine phosphorylation of beta-adducin through inactivation of the transmembrane receptor protein tyrosine phosphatase beta/zeta .
23100427	0	tyrosine	45,53	Pleiotrophin	0,12	tyrosine	Pleiotrophin	CHEBI:18186	5764	Chemical	Gene	/|compound|START_ENTITY suppression|nmod|/ suppression|compound|END_ENTITY	Pleiotrophin suppression of receptor protein tyrosine phosphatase-b / maintains the self-renewal competence of fetal human oligodendrocyte progenitor cells .
7690551	0	tyrosine	24,32	Pleiotrophin	0,12	tyrosine	Pleiotrophin	CHEBI:18186	19242(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Pleiotrophin stimulates tyrosine phosphorylation in NIH 3T3 and NB41A3 cells .
11583917	0	tyrosine	110,118	Prolactin	0,9	tyrosine	Prolactin	CHEBI:18186	5617	Chemical	Gene	kinases|amod|START_ENTITY activation|nmod|kinases induces|nmod|activation induces|nsubj|END_ENTITY	Prolactin induces calcium influx and release from intracellular pools in human T lymphocytes by activation of tyrosine kinases .
1978793	0	tyrosine	35,43	Prolactin	0,9	tyrosine	Prolactin	CHEBI:18186	280901(Tax:9913)	Chemical	Gene	hydroxylase|amod|START_ENTITY activity|nmod|hydroxylase inhibits|dobj|activity inhibits|nsubj|END_ENTITY	Prolactin inhibits the activity of tyrosine hydroxylase in cultured bovine adrenal chromaffin cells in a dose-dependent manner .
8137767	0	tyrosine	32,40	Prolactin	0,9	tyrosine	Prolactin	CHEBI:18186	5617	Chemical	Gene	phosphorylation|compound|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Prolactin induces rapid p95/p70 tyrosine phosphorylation , and protein binding to GAS-like sites in the anx Icp35 and c-fos genes .
9449660	0	tyrosine	93,101	Prolactin	0,9	tyrosine	Prolactin	CHEBI:18186	5617	Chemical	Gene	kinase|compound|START_ENTITY phosphorylation|nmod|kinase phosphorylation|compound|END_ENTITY	Prolactin stimulates phosphorylation of the human T-cell antigen receptor complex and ZAP-70 tyrosine kinase : a potential mechanism for its immunomodulation .
9460655	0	tyrosine	18,26	Prolactin	0,9	tyrosine	Prolactin	CHEBI:18186	24683(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Prolactin induced tyrosine phosphorylation of p59fyn may mediate phosphatidylinositol 3-kinase activation in Nb2 cells .
9516478	0	tyrosine	35,43	Prolactin_receptor	0,18	tyrosine	Prolactin receptor	CHEBI:18186	5618	Chemical	Gene	phosphorylation|compound|START_ENTITY regulates|dobj|phosphorylation regulates|nsubj|END_ENTITY	Prolactin_receptor regulates Stat5 tyrosine phosphorylation and nuclear translocation by two separate pathways .
8547637	0	tyrosine	27,35	Protein_kinase_C	0,16	tyrosine	Protein kinase C	CHEBI:18186	112476	Chemical	Gene	phosphorylation|amod|START_ENTITY regulates|dobj|phosphorylation regulates|nsubj|END_ENTITY	Protein_kinase_C regulates tyrosine phosphorylation of pp125FAK in platelets adherent to fibrinogen .
23521888	0	tyrosine	46,54	Protein_tyrosine_phosphatase-1B	0,31	tyrosine	Protein tyrosine phosphatase-1B	CHEBI:18186	19246(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY regulates|dobj|phosphorylation regulates|nsubj|END_ENTITY	Protein_tyrosine_phosphatase-1B regulates the tyrosine phosphorylation of the adapter Grb2-associated_binder_1 -LRB- Gab1 -RRB- in the retina .
23640882	0	tyrosine	61,69	Protein_tyrosine_phosphatase_1B	0,31	tyrosine	Protein tyrosine phosphatase 1B	D014443	5770	Chemical	Gene	phosphorylation|compound|START_ENTITY regulates|dobj|phosphorylation regulates|nsubj|END_ENTITY	Protein_tyrosine_phosphatase_1B regulates pyruvate_kinase_M2 tyrosine phosphorylation .
10523653	0	tyrosine	124,132	Ptp2	146,150	tyrosine	Ptp2	CHEBI:18186	854383(Tax:4932)	Chemical	Gene	yeast|nmod|START_ENTITY mitogen-activated|nmod|yeast integrity|acl|mitogen-activated regulation|nmod|integrity phosphatases|nsubj|regulation phosphatases|dobj|END_ENTITY	Differential regulation of the cell wall integrity mitogen-activated protein kinase pathway in budding yeast by the protein tyrosine phosphatases Ptp2 and Ptp3 .
10817757	0	tyrosine	12,20	Ptp2	35,39	tyrosine	Ptp2	CHEBI:18186	854383(Tax:4932)	Chemical	Gene	phosphatases|compound|START_ENTITY phosphatases|appos|END_ENTITY	Two protein tyrosine phosphatases , Ptp2 and Ptp3 , modulate the subcellular localization of the Hog1 MAP kinase in yeast .
18212044	0	tyrosine	161,169	Ptp2	148,152	tyrosine	Ptp2	CHEBI:18186	854383(Tax:4932)	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|amod|END_ENTITY	Two adjacent docking sites in the yeast Hog1 mitogen-activated protein -LRB- MAP -RRB- kinase differentially interact with the Pbs2 MAP kinase kinase and the Ptp2 protein tyrosine phosphatase .
16982836	1	tyrosine	66,74	PtpA	44,48	tyrosine	PtpA	CHEBI:18186	5786	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|nsubj|END_ENTITY	paratuberculosis PtpA is an endogenous tyrosine phosphatase secreted during infection .
8575779	0	tyrosine	39,47	Ptprj	61,66	tyrosine	Ptprj	CHEBI:18186	19271(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|genes genes|appos|END_ENTITY	Chromosomal location of murine protein tyrosine phosphatase -LRB- Ptprj and Ptpre -RRB- genes .
11961407	0	tyrosine	16,24	Ptpro	38,43	tyrosine	Ptpro	D014443	50677(Tax:10116)	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|appos|END_ENTITY	GLEPP1 receptor tyrosine phosphatase -LRB- Ptpro -RRB- in rat PAN nephrosis .
26293306	0	tyrosine	13,21	Pvr	0,3	tyrosine	Pvr	D014443	5817	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Pvr receptor tyrosine kinase promotes tissue closure by coordinating corpse removal and epidermal zippering .
10037772	0	tyrosine	22,30	Pyk2	50,54	tyrosine	Pyk2	CHEBI:18186	19229(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	CD28 ligation induces tyrosine phosphorylation of Pyk2 but not Fak in Jurkat T cells .
10373530	0	tyrosine	198,206	Pyk2	226,230	tyrosine	Pyk2	CHEBI:18186	19229(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Induced focal_adhesion_kinase -LRB- FAK -RRB- expression in FAK-null cells enhances cell spreading and migration requiring both auto - and activation loop phosphorylation sites and inhibits adhesion-dependent tyrosine phosphorylation of Pyk2 .
10722671	0	tyrosine	32,40	Pyk2	48,52	tyrosine	Pyk2	CHEBI:18186	2185	Chemical	Gene	Regulation|nmod|START_ENTITY kinase|nsubj|Regulation kinase|dobj|END_ENTITY	Regulation of calcium-sensitive tyrosine kinase Pyk2 by angiotensin_II in endothelial cells .
11997258	0	tyrosine	27,35	Pyk2	22,26	tyrosine	Pyk2	CHEBI:18186	50646(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	ANG_II and LPA induce Pyk2 tyrosine phosphorylation in intestinal epithelial cells : role of Ca2 + , PKC , and Rho kinase .
14701796	0	tyrosine	100,108	Pyk2	95,99	tyrosine	Pyk2	CHEBI:18186	19229(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	The Rap GTPases regulate integrin-mediated adhesion , cell spreading , actin polymerization , and Pyk2 tyrosine phosphorylation in B lymphocytes .
15105428	0	tyrosine	16,24	Pyk2	32,36	tyrosine	Pyk2	CHEBI:18186	2185	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|dobj|END_ENTITY	The cytoplasmic tyrosine kinase Pyk2 as a novel effector of fibroblast_growth_factor_receptor_3 activation .
15128501	0	tyrosine	120,128	Pyk2	98,102	tyrosine	Pyk2	CHEBI:18186	19229(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	The calcium-dependent activity of large-conductance , calcium-activated K + channels is enhanced by Pyk2 - and Hck-induced tyrosine phosphorylation .
16821235	0	tyrosine	98,106	Pyk2	93,97	tyrosine	Pyk2	CHEBI:18186	2185	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	The Rap GTPases mediate CXCL13 - and sphingosine1-phosphate-induced chemotaxis , adhesion , and Pyk2 tyrosine phosphorylation in B lymphocytes .
18954908	0	tyrosine	89,97	Pyk2	106,110	tyrosine	Pyk2	CHEBI:18186	2185	Chemical	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	LPS-induced MCP-1 expression in human microvascular endothelial cells is mediated by the tyrosine kinase , Pyk2 via the p38 MAPK/NF-kappaB-dependent pathway .
26109718	0	tyrosine	33,41	Pyk2	49,53	tyrosine	Pyk2	D014443	2185	Chemical	Gene	role|nmod|START_ENTITY kinase|nsubj|role kinase|dobj|END_ENTITY	A dual role for the non-receptor tyrosine kinase Pyk2 during the intracellular trafficking of human_papillomavirus_16 .
9556630	0	tyrosine	67,75	Pyk2	62,66	tyrosine	Pyk2	CHEBI:18186	19229(Tax:10090)	Chemical	Gene	kinases|compound|START_ENTITY kinases|amod|END_ENTITY	Fluoroaluminate induces activation and association of Src and Pyk2 tyrosine kinases in osteoblastic MC3T3-E1 cells .
8474452	0	tyrosine	82,90	R-PTP-kappa	32,43	tyrosine	R-PTP-kappa	CHEBI:18186	19272(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Cloning Cloning|nmod|END_ENTITY	Cloning and characterization of R-PTP-kappa , a new member of the receptor protein tyrosine phosphatase family with a proteolytically cleaved cellular adhesion molecule-like extracellular region .
11279199	0	tyrosine	83,91	RACK1	111,116	tyrosine	RACK1	CHEBI:18186	10399	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	The interaction of Src and RACK1 is enhanced by activation of protein kinase C and tyrosine phosphorylation of RACK1 .
12400610	9	tyrosine	1080,1088	RAFTK	1074,1079	tyrosine	RAFTK	CHEBI:18186	19229(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|compound|END_ENTITY	Pretreatment of REH cells with a P13 kinase/Akt inhibitor LY_294002 did not inhibit RAFTK tyrosine phosphorylation showing that RAFTK is upstream of P13k/Akt .
9099734	2	tyrosine	547,555	RAFTK	575,580	tyrosine	RAFTK	CHEBI:18186	2185	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Stem_cell_factor , which potentiates the growth of megakaryocytes and their progenitors , and phorbol_myristate_acetate , which causes differentiation of megakaryocytic cell lines , induced the tyrosine phosphorylation of RAFTK but not of focal adhesion kinase .
9446638	0	tyrosine	51,59	RAFTK	67,72	tyrosine	RAFTK	CHEBI:18186	2185	Chemical	Gene	kinase|compound|START_ENTITY signals|nmod|kinase END_ENTITY|nsubj|signals	Beta-chemokine receptor CCR5 signals via the novel tyrosine kinase RAFTK .
21494799	0	tyrosine	87,95	RAGE	67,71	tyrosine	RAGE	CHEBI:18186	177	Chemical	Gene	pathways|compound|START_ENTITY pathways|compound|END_ENTITY	HMGB1 increases permeability of the endothelial cell monolayer via RAGE and Src family tyrosine kinase pathways .
27018250	0	tyrosine	43,51	RBM39	85,90	tyrosine	RBM39	D014443	9584	Chemical	Gene	interaction|nmod|START_ENTITY kinase|nsubj|interaction kinase|dobj|END_ENTITY	Functional interaction between nonreceptor tyrosine kinase c-Abl and SR-Rich protein RBM39 .
10027004	0	tyrosine	32,40	RET	18,21	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	START_ENTITY|nsubj|Rearrangements Rearrangements|nmod|END_ENTITY	Rearrangements of RET and NTRK1 tyrosine kinase receptors in papillary_thyroid_carcinomas .
10233387	0	tyrosine	17,25	RET	4,7	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The RET receptor tyrosine kinase , but not its specific ligand , GDNF , is preferentially expressed by acute leukaemias of monocytic phenotype and is up-regulated upon differentiation .
10439047	0	tyrosine	88,96	RET	75,78	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The transcription coactivator HTIF1 and a related protein are fused to the RET receptor tyrosine kinase in childhood papillary_thyroid_carcinomas .
10443680	3	tyrosine	363,371	RET	380,383	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	kinases|amod|START_ENTITY kinases|dep|END_ENTITY	Because of similarities in involvement of the two tyrosine kinases RET -LRB- rearranged_during_transfection -RRB- and NTRK1 in the pathogenesis of PTC , the obvious parallels between RET and NTRK1 and between PTC and medullary_thyroid_carcinoma -LRB- MTC -RRB- , NTRK1 seemed to be an excellent candidate gene to play a role in the genesis of MTC .
11316186	0	tyrosine	38,46	RET	70,73	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|proto-oncogene proto-oncogene|compound|END_ENTITY	A homozygous missense mutation in the tyrosine E kinase domain of the RET proto-oncogene in an infant with total_intestinal_aganglionosis .
11340615	5	tyrosine	1002,1010	RET	1019,1022	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	kinases|nsubj|START_ENTITY kinases|dobj|END_ENTITY	RESULTS : In various sporadic thyroid_tumor types of adults structural genetic aberrations have been found involving mutations of RAS -LRB- codon 12 , 13 , 61 -RRB- , p53 -LRB- exons 5 to 8 -RRB- , Gsalpha -LRB- codon 201 and 227 -RRB- , and , at a low prevalence , the receptor tyrosine kinases RET or NTRK1 .
11390647	0	tyrosine	39,47	RET	55,58	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|dobj|END_ENTITY	Docking protein FRS2 links the protein tyrosine kinase RET and its oncogenic forms with the mitogen-activated_protein kinase signaling cascade .
11520496	0	tyrosine	193,201	RET	29,32	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	1062|amod|START_ENTITY antibody|nmod|1062 study|nmod|antibody phosphorylation|dep|study phosphorylation|nmod|protein protein|compound|END_ENTITY	Preserved phosphorylation of RET receptor protein in spinal motor neurons of patients with amyotrophic_lateral_sclerosis : an immunohistochemical study by a phosphorylation-specific antibody at tyrosine 1062 .
11562352	0	tyrosine	35,43	RET	31,34	tyrosine	RET	CHEBI:18186	19713(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Differential activities of the RET tyrosine kinase receptor isoforms during mammalian embryogenesis .
11579677	0	tyrosine	23,31	RET	19,22	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	START_ENTITY|nsubj|prevalence prevalence|nmod|END_ENTITY	High prevalence of RET tyrosine kinase activation in Mexican patients with papillary_thyroid_carcinomas .
11709725	0	tyrosine	4,12	RET	0,3	tyrosine	RET	CHEBI:18186	19713(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	RET tyrosine kinase enhances hair growth in association with promotion of melanogenesis .
11713247	0	tyrosine	103,111	RET	59,62	tyrosine	RET	CHEBI:18186	24716(Tax:10116)	Chemical	Gene	1062|amod|START_ENTITY importance|nmod|1062 sites|dep|importance sites|nmod|kinase kinase|compound|END_ENTITY	Coordinated activation of autophosphorylation sites in the RET receptor tyrosine kinase : importance of tyrosine 1062 for GDNF mediated neuronal differentiation and survival .
11713247	0	tyrosine	72,80	RET	59,62	tyrosine	RET	CHEBI:18186	24716(Tax:10116)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Coordinated activation of autophosphorylation sites in the RET receptor tyrosine kinase : importance of tyrosine 1062 for GDNF mediated neuronal differentiation and survival .
11886862	0	tyrosine	80,88	RET	76,79	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	START_ENTITY|nsubj|mechanism mechanism|nmod|regulation regulation|nmod|activity activity|nmod|END_ENTITY	Novel mechanism of regulation of Rac activity and lamellipodia formation by RET tyrosine kinase .
12056817	0	tyrosine	18,26	RET	14,17	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Activation of RET tyrosine kinase regulates interleukin-8 production by multiple signaling pathways .
12087092	0	tyrosine	47,55	RET	43,46	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Role of Dok1 in cell signaling mediated by RET tyrosine kinase .
12165857	0	tyrosine	13,21	RET	0,3	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	START_ENTITY|nsubj|receptor receptor|compound|END_ENTITY	RET receptor tyrosine kinase isoforms in kidney function and disease .
12399307	0	tyrosine	38,46	RET	54,57	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	signalling|nmod|START_ENTITY Requirement|acl|signalling kinase|nsubj|Requirement kinase|dobj|END_ENTITY	Requirement of signalling by receptor tyrosine kinase RET for the directed migration of enteric nervous system progenitor cells during mammalian embryogenesis .
12499271	0	tyrosine	45,53	RET	100,103	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	activity|amod|START_ENTITY inhibitor|nmod|activity ZD6474|appos|inhibitor blocks|nsubj|ZD6474 blocks|dobj|kinases kinases|compound|END_ENTITY	ZD6474 , an orally available inhibitor of KDR tyrosine kinase activity , efficiently blocks oncogenic RET kinases .
12499271	1	tyrosine	196,204	RET	231,234	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	RET/papillary _ thyroid_carcinoma -LRB- PTC -RRB- oncogenes , generated by recombination of the tyrosine kinase-encoding domain of RET with different heterologous genes , are prevalent in papillary_carcinomas of the thyroid .
12755958	0	tyrosine	52,60	RET	48,51	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	START_ENTITY|nsubj|signalling signalling|acl|mediated mediated|nmod|END_ENTITY	Cell signalling and gene expression mediated by RET tyrosine kinase .
12771945	0	tyrosine	100,108	RET	36,39	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	kinase|amod|START_ENTITY controlling|dobj|kinase mechanism|acl|controlling evidence|nmod|mechanism activation|dep|evidence activation|nmod|END_ENTITY	Protein kinase Calpha activation by RET : evidence for a negative feedback mechanism controlling RET tyrosine kinase .
12771945	0	tyrosine	100,108	RET	96,99	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Protein kinase Calpha activation by RET : evidence for a negative feedback mechanism controlling RET tyrosine kinase .
15184865	0	tyrosine	63,71	RET	50,53	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Disease associated mutations at valine 804 in the RET receptor tyrosine kinase confer resistance to selective kinase inhibitors .
15240641	0	tyrosine	83,91	RET	30,33	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	domain|compound|START_ENTITY involving|dobj|domain protooncogene|xcomp|involving protooncogene|nsubj|mutation mutation|nmod|END_ENTITY	A novel point mutation of the RET protooncogene involving the second intracellular tyrosine kinase domain in a family with medullary_thyroid_carcinoma .
15769183	0	tyrosine	69,77	RET	56,59	tyrosine	RET	D014443	5979	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Neutralizing aptamers from whole-cell SELEX inhibit the RET receptor tyrosine kinase .
15769183	0	tyrosine	69,77	RET	56,59	tyrosine	RET	D014443	5979	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Neutralizing aptamers from whole-cell SELEX inhibit the RET receptor tyrosine kinase .
15802236	0	tyrosine	54,62	RET	50,53	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression , purification , and inhibition of human RET tyrosine kinase .
15978587	0	tyrosine	34,42	RET	11,14	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	kinase|compound|START_ENTITY contains|dobj|kinase contains|nsubj|END_ENTITY	Drosophila RET contains an active tyrosine kinase and elicits neurotrophic activities in mammalian cells .
16256137	0	tyrosine	120,128	RET	146,149	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	NTRK1|compound|START_ENTITY NTRK1|compound|END_ENTITY	Identification of differentially expressed genes in papillary_thyroid_carcinomas with and without rearrangements of the tyrosine kinase receptors RET and/or NTRK1 .
16469774	0	tyrosine	39,47	RET	35,38	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	A novel activating mutation in the RET tyrosine kinase domain mediates neoplastic transformation .
16843637	0	tyrosine	24,32	RET	0,3	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	changes|amod|START_ENTITY induce|dobj|changes oncoproteins|xcomp|induce oncoproteins|nsubj|END_ENTITY	RET oncoproteins induce tyrosine phosphorylation changes of proteins involved in RNA metabolism .
17032739	0	tyrosine	18,26	RET	14,17	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of RET tyrosine kinase by SU5416 .
17334087	0	tyrosine	72,80	RET	68,71	tyrosine	RET	CHEBI:18186	19713(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|induction induction|nmod|END_ENTITY	-LSB- Ultraviolet irradiation-mediated malignant_melanoma induction with RET tyrosine kinase activation -RSB- .
17388787	0	tyrosine	87,95	RET	83,86	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Sprouty2 regulates growth and differentiation of human neuroblastoma cells through RET tyrosine kinase .
17471236	0	tyrosine	43,51	RET	39,42	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	SH2B1beta adaptor is a key enhancer of RET tyrosine kinase signaling .
17625109	0	tyrosine	112,120	RET	108,111	tyrosine	RET	CHEBI:18186	19713(Tax:10090)	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Gfra1 silencing in mouse spermatogonial stem cells results in their differentiation via the inactivation of RET tyrosine kinase .
17639056	0	tyrosine	70,78	RET	66,69	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	START_ENTITY|nsubj|medullary_thyroid_carcinoma medullary_thyroid_carcinoma|nmod|model model|nmod|END_ENTITY	A transplantable human medullary_thyroid_carcinoma as a model for RET tyrosine kinase-driven tumorigenesis .
17664273	0	tyrosine	45,53	RET	41,44	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Sorafenib functions to potently suppress RET tyrosine kinase activity by direct enzymatic inhibition and promoting RET lysosomal degradation independent of proteasomal targeting .
17761947	0	tyrosine	125,133	RET	171,174	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	kinase|compound|START_ENTITY kinase|acl|rearranged rearranged|nmod|transformation transformation|appos|END_ENTITY	Tumor suppressor LKB1 inhibits activation of signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- by thyroid oncogenic tyrosine kinase rearranged in transformation -LRB- RET -RRB- / papillary_thyroid_carcinoma -LRB- PTC -RRB- .
18031721	0	tyrosine	13,21	RET	29,32	tyrosine	RET	CHEBI:18186	396107(Tax:9031)	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|ccomp|regulates regulates|nsubj|END_ENTITY	The receptor tyrosine kinase RET regulates hindgut colonization by sacral neural crest cells .
19029224	0	tyrosine	18,26	RET	61,64	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	START_ENTITY|nmod|determinant determinant|nmod|END_ENTITY	Identification of tyrosine 806 as a molecular determinant of RET kinase sensitivity to ZD6474 .
19075852	0	tyrosine	30,38	RET	46,49	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	inventions|nmod|START_ENTITY kinase|nsubj|inventions kinase|dobj|modulation modulation|compound|END_ENTITY	Recent inventions on receptor tyrosine kinase RET modulation .
19366855	0	tyrosine	4,12	RET	29,32	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	receptor|amod|START_ENTITY END_ENTITY|nsubj|receptor	The tyrosine kinase receptor RET interacts in vivo with aryl_hydrocarbon_receptor-interacting_protein to alter survivin availability .
20235151	0	tyrosine	54,62	RET	50,53	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	START_ENTITY|nsubj|pathway pathway|nmod|END_ENTITY	A redox-linked novel pathway for arsenic-mediated RET tyrosine kinase activation .
20409618	0	tyrosine	22,30	RET	18,21	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Inhibitors of the RET tyrosine kinase based on a 2 - -LRB- alkylsulfanyl -RRB- -4 - -LRB- 3-thienyl -RRB- nicotinonitrile scaffold .
20531297	0	tyrosine	23,31	RET	39,42	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	Targeting|dobj|START_ENTITY kinase|csubj|Targeting kinase|ccomp|sensitizes sensitizes|nsubj|END_ENTITY	Targeting the receptor tyrosine kinase RET sensitizes breast_cancer cells to tamoxifen treatment and reveals a role for RET in endocrine resistance .
20682772	0	tyrosine	137,145	RET	124,127	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Protein-tyrosine phosphatase SHP2 contributes to GDNF neurotrophic activity through direct binding to phospho-Tyr687 in the RET receptor tyrosine kinase .
20930041	0	tyrosine	23,31	RET	10,13	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	START_ENTITY|nsubj|receptor receptor|compound|END_ENTITY	Targeting RET receptor tyrosine kinase activation in cancer .
20943719	0	tyrosine	4,12	RET	61,64	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	ZD6474|amod|START_ENTITY blocks|nsubj|ZD6474 blocks|dobj|proliferation proliferation|nmod|cells cells|compound|END_ENTITY	The tyrosine kinase inhibitor ZD6474 blocks proliferation of RET mutant medullary_thyroid_carcinoma cells .
22128160	0	tyrosine	94,102	RET	81,84	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	START_ENTITY|nsubj|Identification Identification|nmod|motif motif|acl:relcl|determines determines|dobj|levels levels|nmod|END_ENTITY	Identification of a key motif that determines the differential surface levels of RET and TrkB tyrosine kinase receptors and controls depolarization enhanced RET surface insertion .
22326552	0	tyrosine	57,65	RET	53,56	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	reorganization|amod|START_ENTITY reorganization|compound|END_ENTITY	GDNF restores human blood-nerve barrier function via RET tyrosine kinase-mediated cytoskeletal reorganization .
22971345	0	tyrosine	121,129	RET	117,120	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Endoneurial macrophages induce perineural invasion of pancreatic_cancer cells by secretion of GDNF and activation of RET tyrosine kinase receptor .
23413818	0	tyrosine	37,45	RET	24,27	tyrosine	RET	CHEBI:18186	24716(Tax:10116)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The isolectin IB4 binds RET receptor tyrosine kinase in microglia .
23780998	0	tyrosine	48,56	RET	13,16	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	kinases|amod|START_ENTITY expression|nmod|kinases Influence|nmod|expression Influence|nmod|mutations mutations|compound|END_ENTITY	Influence of RET mutations on the expression of tyrosine kinases in medullary_thyroid_carcinoma .
24437351	0	tyrosine	103,111	RET	136,139	tyrosine	RET	CHEBI:18186	19713(Tax:10090)	Chemical	Gene	auto-phosphorylation|compound|START_ENTITY auto-phosphorylation|nmod|proteins proteins|compound|END_ENTITY	The involvement of reactive oxygen species derived from NADPH_oxidase-1 activation on the constitutive tyrosine auto-phosphorylation of RET proteins .
26033033	0	tyrosine	107,115	RET	45,48	tyrosine	RET	D014443	5979	Chemical	Gene	START_ENTITY|nsubj|neoplasia neoplasia|nmod|carriers carriers|nmod|mutation mutation|compound|END_ENTITY	C-cell neoplasia in asymptomatic carriers of RET mutation in extracellular cysteine-rich and intracellular tyrosine kinase domain .
26044359	0	tyrosine	93,101	RET	89,92	tyrosine	RET	D014443	5979	Chemical	Gene	kinase|amod|START_ENTITY END_ENTITY|dobj|kinase	Characterization of interactions and pharmacophore development for DFG-out inhibitors to RET tyrosine kinase .
26950000	0	tyrosine	90,98	RET	86,89	tyrosine	RET	D014443	5979	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Defects in the calcium-binding region drastically affect the cadherin-like domains of RET tyrosine kinase .
7627271	0	tyrosine	32,40	RET	62,65	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|proto-oncogene proto-oncogene|compound|END_ENTITY	Tumor-specific mutations in the tyrosine kinase domain of the RET proto-oncogene in pheochromocytomas of sporadic type .
7845675	0	tyrosine	30,38	RET	60,63	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|proto-oncogene proto-oncogene|compound|END_ENTITY	A novel point mutation in the tyrosine kinase domain of the RET proto-oncogene in sporadic medullary_thyroid_carcinoma and in a family with FMTC .
7906417	0	tyrosine	32,40	RET	72,75	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|protooncogene protooncogene|compound|END_ENTITY	Single missense mutation in the tyrosine kinase catalytic domain of the RET protooncogene is associated with multiple_endocrine_neoplasia_type_2B .
7911697	0	tyrosine	26,34	RET	56,59	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|proto-oncogene proto-oncogene|compound|END_ENTITY	Point mutation within the tyrosine kinase domain of the RET proto-oncogene in multiple_endocrine_neoplasia_type_2B and related sporadic_tumours .
8114938	0	tyrosine	30,38	RET	60,63	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|proto-oncogene proto-oncogene|compound|END_ENTITY	Point mutations affecting the tyrosine kinase domain of the RET proto-oncogene in Hirschsprung 's _ disease .
8494786	0	tyrosine	16,24	RET	12,15	tyrosine	RET	CHEBI:18186	24716(Tax:10116)	Chemical	Gene	oncogenes|compound|START_ENTITY oncogenes|compound|END_ENTITY	The TRK and RET tyrosine kinase oncogenes cooperate with ras in the neoplastic transformation of a rat thyroid epithelial cell line .
8626874	0	tyrosine	30,38	RET	70,73	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	receptor|amod|START_ENTITY activation|nmod|receptor protooncogenes|nsubj|activation protooncogenes|dobj|END_ENTITY	Age-related activation of the tyrosine kinase receptor protooncogenes RET and NTRK1 in papillary_thyroid_carcinoma .
8670046	0	tyrosine	75,83	RET	18,21	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	activity|amod|START_ENTITY affects|dobj|activity affects|nsubj|mutation mutation|nmod|proto-oncogene proto-oncogene|compound|END_ENTITY	A mutation in the RET proto-oncogene in Hirschsprung 's _ disease affects the tyrosine kinase activity associated with multiple_endocrine_neoplasia_type_2A and 2B .
8855235	0	tyrosine	67,75	RET	83,86	tyrosine	RET	CHEBI:18186	5979	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|dobj|END_ENTITY	Glial_cell_line-derived_neurotrophic_factor activates the receptor tyrosine kinase RET and promotes kidney morphogenesis .
9242375	0	tyrosine	73,81	RET	24,27	tyrosine	RET	CHEBI:18186	24716(Tax:10116)	Chemical	Gene	domain|amod|START_ENTITY affecting|dobj|domain activation|acl|affecting activation|nmod|END_ENTITY	Oncogenic activation of RET by two distinct FMTC mutations affecting the tyrosine kinase domain .
9627110	8	tyrosine	1353,1361	RET	1264,1267	tyrosine	JNK	CHEBI:18186	5599	Chemical	Gene	1062|amod|START_ENTITY substitution|nmod|1062 divergent|nmod|substitution divergent|nsubj|pathway pathway|acl|leading leading|nmod|END_ENTITY	The pathway leading to the activation of JNK by RET is clearly divergent from that leading to the activation of ERK : substitution of the tyrosine 1062 of Ret , the Shc binding site , for phenylalanine abrogates ERK but not JNK activation .
21339287	0	tyrosine	48,56	RGDS	27,31	tyrosine	RGDS	CHEBI:18186	5900	Chemical	Gene	phosphorylation|compound|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	The integrin-binding motif RGDS induces protein tyrosine phosphorylation without activation in Bufo arenarum -LRB- Amphibia -RRB- oocytes .
12588871	0	tyrosine	19,27	RGS16	13,18	tyrosine	RGS16	CHEBI:18186	6004	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Src-mediated RGS16 tyrosine phosphorylation promotes RGS16 stability .
10679022	0	tyrosine	77,85	RIM11	71,76	tyrosine	RIM11	CHEBI:18186	855170(Tax:4932)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Essential functions of protein tyrosine phosphatases PTP2 and PTP3 and RIM11 tyrosine phosphorylation in Saccharomyces_cerevisiae meiosis and sporulation .
15886098	8	tyrosine	938,946	RIN1	977,981	tyrosine	RIN1	CHEBI:18186	225870(Tax:10090)	Chemical	Gene	function|amod|START_ENTITY function|nmod|END_ENTITY	Activated RAS participates in a stable RAS-RIN1-ABL2 complex and stimulates the tyrosine kinase-activation function of RIN1 .
10631120	0	tyrosine	20,28	RON	82,85	tyrosine	RON	CHEBI:18186	4486	Chemical	Gene	Requirement|nmod|START_ENTITY residues|nsubj|Requirement residues|nmod|tail tail|nmod|receptor_tyrosine_kinase receptor_tyrosine_kinase|compound|END_ENTITY	Requirement of both tyrosine residues 1330 and 1337 in the C-terminal tail of the RON receptor_tyrosine_kinase for epithelial cell scattering and migration .
10725742	0	tyrosine	31,39	RON	18,21	tyrosine	RON	CHEBI:18186	19882(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|receptor receptor|compound|END_ENTITY	Regulation of the RON receptor tyrosine kinase expression in macrophages : blocking the RON gene transcription by endotoxin-induced nitric_oxide .
10725742	0	tyrosine	31,39	RON	87,90	tyrosine	RON	CHEBI:18186	19882(Tax:10090)	Chemical	Gene	START_ENTITY|parataxis|blocking blocking|dobj|transcription transcription|compound|END_ENTITY	Regulation of the RON receptor tyrosine kinase expression in macrophages : blocking the RON gene transcription by endotoxin-induced nitric_oxide .
10747844	0	tyrosine	70,78	RON	18,21	tyrosine	RON	CHEBI:18186	4486	Chemical	Gene	activity|amod|START_ENTITY requires|dobj|activity requires|nsubj|phosphorylation phosphorylation|compound|END_ENTITY	Integrin-mediated RON growth factor receptor phosphorylation requires tyrosine kinase activity of both the receptor and c-Src .
11332718	0	tyrosine	32,40	RON	19,22	tyrosine	RON	CHEBI:18186	4486	Chemical	Gene	START_ENTITY|nsubj|Cross-talk Cross-talk|nmod|receptor receptor|compound|END_ENTITY	Cross-talk between RON receptor tyrosine kinase and other transmembrane receptors .
11486025	0	tyrosine	42,50	RON	21,24	tyrosine	RON	CHEBI:18186	4486	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Oncogenic mutants of RON and MET receptor tyrosine kinases cause activation of the beta-catenin pathway .
11818458	0	tyrosine	31,39	RON	18,21	tyrosine	RON	CHEBI:18186	19882(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Activation of the RON receptor tyrosine kinase protects murine macrophages from apoptotic death induced by bacterial lipopolysaccharide .
12177064	0	tyrosine	31,39	RON	18,21	tyrosine	RON	CHEBI:18186	19882(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Activation of the RON receptor tyrosine kinase by macrophage-stimulating protein inhibits inducible cyclooxygenase-2 expression in murine macrophages .
12214279	0	tyrosine	36,44	RON	148,151	tyrosine	RON	CHEBI:18186	4486	Chemical	Gene	expression|nmod|START_ENTITY kinase|nsubj|expression kinase|dobj|RON RON|dep|potential potential|nmod|END_ENTITY	Targeted expression of the receptor tyrosine kinase RON in distal lung epithelial cells results in multiple tumor formation : oncogenic potential of RON in vivo .
12214279	0	tyrosine	36,44	RON	52,55	tyrosine	RON	CHEBI:18186	4486	Chemical	Gene	expression|nmod|START_ENTITY kinase|nsubj|expression kinase|dobj|END_ENTITY	Targeted expression of the receptor tyrosine kinase RON in distal lung epithelial cells results in multiple tumor formation : oncogenic potential of RON in vivo .
12527888	0	tyrosine	39,47	RON	133,136	tyrosine	RON	CHEBI:18186	4486	Chemical	Gene	kinase|compound|START_ENTITY expression|nmod|kinase expression|dep|generation generation|nmod|variants variants|compound|END_ENTITY	Altered expression of the RON receptor tyrosine kinase in primary human colorectal_adenocarcinomas : generation of different splicing RON variants and their oncogenic potential .
12527888	0	tyrosine	39,47	RON	26,29	tyrosine	RON	CHEBI:18186	4486	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Altered expression of the RON receptor tyrosine kinase in primary human colorectal_adenocarcinomas : generation of different splicing RON variants and their oncogenic potential .
12676986	0	tyrosine	50,58	RON	37,40	tyrosine	RON	CHEBI:18186	4486	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte_sheep_retrovirus .
15557181	0	tyrosine	13,21	RON	0,3	tyrosine	RON	CHEBI:18186	4486	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	RON receptor tyrosine kinase , a negative regulator of inflammation , inhibits HIV-1 transcription in monocytes/macrophages and is decreased in brain tissue from patients with AIDS .
15632155	0	tyrosine	22,30	RON	18,21	tyrosine	RON	CHEBI:18186	4486	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	The C terminus of RON tyrosine kinase plays an autoinhibitory role .
16880737	0	tyrosine	119,127	RON	106,109	tyrosine	RON	CHEBI:18186	4486	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Agonistic monoclonal antibodies potentiate tumorigenic and invasive activities of splicing variant of the RON receptor tyrosine kinase .
16982759	0	tyrosine	105,113	RON	122,125	tyrosine	RON	CHEBI:18186	4486	Chemical	Gene	START_ENTITY|dobj|kinase kinase|appos|END_ENTITY	Therapeutic implications of a human neutralizing antibody to the macrophage-stimulating_protein receptor tyrosine kinase -LRB- RON -RRB- , a c-MET family member .
17611409	0	tyrosine	111,119	RON	73,76	tyrosine	RON	CHEBI:18186	4486	Chemical	Gene	domain|amod|START_ENTITY variant|nmod|domain variant|csubj|Blocking Blocking|nmod|receptor receptor|compound|END_ENTITY	Blocking tumorigenic activities of colorectal_cancer cells by a splicing RON receptor variant defective in the tyrosine kinase domain .
18209063	0	tyrosine	13,21	RON	29,32	tyrosine	RON	CHEBI:18186	4486	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|ccomp|represses represses|nsubj|END_ENTITY	The receptor tyrosine kinase RON represses HIV-1 transcription by targeting RNA polymerase II processivity .
18310076	0	tyrosine	59,67	RON	46,49	tyrosine	RON	CHEBI:18186	4486	Chemical	Gene	START_ENTITY|nsubj|receptor receptor|compound|END_ENTITY	Smad4-dependent TGF-beta signaling suppresses RON receptor tyrosine kinase-dependent motility and invasion of pancreatic_cancer cells .
18684919	0	tyrosine	17,25	RON	4,7	tyrosine	RON	CHEBI:18186	19882(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The RON receptor tyrosine kinase regulates IFN-gamma production and responses in innate immunity .
20039696	0	tyrosine	13,21	RON	0,3	tyrosine	RON	CHEBI:18186	4486	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	RON receptor tyrosine kinase as a target for delivery of chemodrugs by antibody directed pathway for cancer cell cytotoxicity .
20596675	0	tyrosine	66,74	RON	53,56	tyrosine	RON	CHEBI:18186	4486	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Monoclonal antibody -LRB- mAb -RRB- - induced down-regulation of RON receptor tyrosine kinase diminishes tumorigenic activities of colon_cancer cells .
20658288	0	tyrosine	127,135	RON	114,117	tyrosine	RON	CHEBI:18186	4486	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|specific specific|nmod|receptor receptor|compound|END_ENTITY	Targeting acute_hypoxic_cancer cells by doxorubicin-immunoliposomes directed by monoclonal antibodies specific to RON receptor tyrosine kinase .
21619683	0	tyrosine	83,91	RON	70,73	tyrosine	RON	CHEBI:18186	4486	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Ribosomal_protein_S6_kinase -LRB- RSK -RRB- -2 as a central effector molecule in RON receptor tyrosine kinase mediated epithelial to mesenchymal transition induced by macrophage-stimulating_protein .
21749705	0	tyrosine	53,61	RON	40,43	tyrosine	RON	CHEBI:18186	4486	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The monoclonal antibody Zt/f2 targeting RON receptor tyrosine kinase as potential therapeutics against tumor growth-mediated by colon_cancer cells .
22014215	0	tyrosine	41,49	RON	28,31	tyrosine	RON	CHEBI:18186	4486	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Sustained expression of the RON receptor tyrosine kinase by pancreatic_cancer stem cells as a potential targeting moiety for antibody-directed chemotherapeutics .
22975341	0	tyrosine	104,112	RON	23,26	tyrosine	RON	CHEBI:18186	4486	Chemical	Gene	phosphorylation|amod|START_ENTITY lacks|dobj|phosphorylation cells|acl:relcl|lacks derived|nmod|cells derived|nsubj|variant variant|nmod|kinase kinase|compound|END_ENTITY	A novel variant of the RON receptor tyrosine kinase derived from colorectal_carcinoma cells which lacks tyrosine phosphorylation but induces cell migration .
22975341	0	tyrosine	36,44	RON	23,26	tyrosine	RON	CHEBI:18186	4486	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	A novel variant of the RON receptor tyrosine kinase derived from colorectal_carcinoma cells which lacks tyrosine phosphorylation but induces cell migration .
23360784	0	tyrosine	17,25	RON	4,7	tyrosine	RON	CHEBI:18186	4486	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The RON receptor tyrosine kinase is a potential therapeutic target in Burkitt_lymphoma .
24086167	0	tyrosine	29,37	RON	16,19	tyrosine	RON	CHEBI:18186	4486	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Pathogenesis of RON receptor tyrosine kinase in cancer cells : activation mechanism , functional crosstalk , and signaling addiction .
24388747	0	tyrosine	17,25	RON	4,7	tyrosine	RON	CHEBI:18186	4486	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The RON receptor tyrosine kinase promotes metastasis by triggering MBD4-dependent DNA methylation reprogramming .
26112445	0	tyrosine	71,79	RON	67,70	tyrosine	RON	D014443	4486	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Design and synthesis of constrained analogs of LCRF-0004 as potent RON tyrosine kinase inhibitors .
26477314	0	tyrosine	35,43	RON	31,34	tyrosine	RON	D014443	4486	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	A novel protein isoform of the RON tyrosine kinase receptor transforms human_pancreatic_duct_epithelial cells .
26721331	0	tyrosine	93,101	RON	80,83	tyrosine	RON	D014443	4486	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Glycomic analysis of gastric_carcinoma cells discloses glycans as modulators of RON receptor tyrosine kinase activation in cancer .
26930004	0	tyrosine	86,94	RON	73,76	tyrosine	RON	D014443	4486	Chemical	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	hnRNP_A1-mediated translational regulation of the G quadruplexcontaining RON receptor tyrosine kinase mRNA linked to tumor progression .
7732008	2	tyrosine	328,336	RON	313,316	tyrosine	stk	CHEBI:18186	19882(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY product|appos|kinase product|nmod|END_ENTITY	We recently showed that the product of RON , a protein tyrosine kinase cloned from a human keratinocyte library , is the receptor for MSP .
8062829	0	tyrosine	23,31	RON	0,3	tyrosine	RON	CHEBI:18186	4486	Chemical	Gene	receptor|amod|START_ENTITY receptor|nsubj|END_ENTITY	RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP .
8695717	0	tyrosine	70,78	RON	49,52	tyrosine	RON	CHEBI:18186	4486	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|ligand ligand|nmod|protein protein|compound|END_ENTITY	Macrophage-stimulating_protein , a ligand for the RON receptor protein tyrosine kinase , suppresses myeloid progenitor cell proliferation and synergizes with vascular endothelial cell growth factor and members of the chemokine family .
8816464	0	tyrosine	62,70	RON	26,29	tyrosine	RON	CHEBI:18186	4486	Chemical	Gene	activity|amod|START_ENTITY induces|dobj|activity induces|nsubj|variant variant|nmod|transcript transcript|compound|END_ENTITY	A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotype .
9533936	7	tyrosine	1557,1565	RON	1453,1456	tyrosine	RON	CHEBI:18186	4486	Chemical	Gene	phosphorylation|compound|START_ENTITY inducing|dobj|phosphorylation MSP|acl|inducing functional|nmod|MSP functional|nsubj|END_ENTITY	RON was functional in all tested RON mRNA-positive cell lines , with exogenous MSP inducing RON-mediated tyrosine phosphorylation .
22369092	0	tyrosine	29,37	ROR-1	46,51	tyrosine	ROR-1	CHEBI:18186	4919	Chemical	Gene	START_ENTITY|dobj|expression expression|appos|END_ENTITY	Detection of orphan receptor tyrosine kinase -LRB- ROR-1 -RRB- expression in Egyptian pediatric acute_lymphoblastic_leukemia .
18223214	0	tyrosine	43,51	ROR1	59,63	tyrosine	ROR1	D014443	4919	Chemical	Gene	expression|nmod|START_ENTITY kinase|nsubj|expression kinase|dobj|END_ENTITY	Unique cell surface expression of receptor tyrosine kinase ROR1 in human B-cell_chronic_lymphocytic_leukemia .
22988987	0	tyrosine	16,24	ROR1	33,37	tyrosine	ROR1	CHEBI:18186	4919	Chemical	Gene	kinases|nsubj|START_ENTITY kinases|dobj|END_ENTITY	Orphan receptor tyrosine kinases ROR1 and ROR2 in hematological_malignancies .
10700182	0	tyrosine	56,64	ROR2	22,26	tyrosine	ROR2	CHEBI:18186	26564(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY encoding|dobj|kinase cause|advcl|encoding cause|nsubj|mutations mutations|nmod|END_ENTITY	Dominant mutations in ROR2 , encoding an orphan receptor tyrosine kinase , cause brachydactyly type B. Inherited_limb_malformations provide a valuable resource for the identification of genes involved in limb development .
10932187	0	tyrosine	39,47	ROR2	34,38	tyrosine	ROR2	CHEBI:18186	4920	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Mutation of the gene encoding the ROR2 tyrosine kinase causes autosomal recessive Robinow_syndrome .
10986040	0	tyrosine	35,43	ROR2	56,60	tyrosine	ROR2	CHEBI:18186	4920	Chemical	Gene	Brachydactyly_type_B|compound|START_ENTITY Brachydactyly_type_B|compound|END_ENTITY	Distinct mutations in the receptor tyrosine kinase gene ROR2 cause brachydactyly type B. Brachydactyly_type_B -LRB- BDB -RRB- is an autosomal_dominant_skeletal_disorder characterized by hypoplasia/aplasia of distal phalanges and nails .
19802008	0	tyrosine	11,19	ROR2	37,41	tyrosine	ROR2	CHEBI:18186	4920	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	The orphan tyrosine kinase receptor , ROR2 , mediates Wnt5A signaling in metastatic_melanoma .
23233346	0	tyrosine	40,48	ROR2	57,61	tyrosine	ROR2	CHEBI:18186	4920	Chemical	Gene	role|nmod|START_ENTITY role|amod|END_ENTITY	The dual role of the novel Wnt receptor tyrosine kinase , ROR2 , in human carcinogenesis .
23238279	0	tyrosine	273,281	ROR2	32,36	tyrosine	ROR2	CHEBI:18186	4920	Chemical	Gene	kinase|compound|START_ENTITY encoding|dobj|kinase characterized|xcomp|encoding characterized|advcl|underlying underlying|nsubj|mutation mutation|nmod|END_ENTITY	A nonsense mutation in the gene ROR2 underlying autosomal dominant brachydactyly type B. Brachydactyly_type_B1 -LRB- BDB1 -RRB- , an autosomal_dominant_condition characterized by terminal deficiency_of_the_fingers_and_toes , results from mutations in the gene ROR2 encoding a receptor tyrosine kinase .
26003414	0	tyrosine	9,17	ROR2	4,8	tyrosine	ROR2	D014443	4920	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	The ROR2 tyrosine kinase receptor regulates dendritic spine morphogenesis in hippocampal neurons .
26531175	0	tyrosine	20,28	ROR2	36,40	tyrosine	ROR2	D014443	26564(Tax:10090)	Chemical	Gene	START_ENTITY|ccomp|MSCs MSCs|nsubj|facilitates facilitates|compound|END_ENTITY	The orphan receptor tyrosine kinase ROR2 facilitates MSCs to repair lung_injury in ARDS animal model .
22915320	0	tyrosine	14,22	ROS1	0,4	tyrosine	ROS1	CHEBI:18186	6098	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	ROS1 receptor tyrosine kinase , a druggable target , is frequently overexpressed in non-small_cell_lung_carcinomas via genetic and epigenetic mechanisms .
24386191	0	tyrosine	80,88	ROS1	75,79	tyrosine	ROS1	CHEBI:18186	19886(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Discovery and preclinical characterization of novel small molecule TRK and ROS1 tyrosine kinase inhibitors for the treatment of cancer and inflammation .
21454675	0	tyrosine	22,30	RPTP-beta	49,58	tyrosine	RPTP-beta	CHEBI:18186	5803	Chemical	Gene	beta|compound|START_ENTITY beta|appos|END_ENTITY	Receptor-type protein tyrosine phosphatase beta -LRB- RPTP-beta -RRB- directly dephosphorylates and regulates hepatocyte_growth_factor receptor -LRB- HGFR/Met -RRB- function .
11313993	0	tyrosine	89,97	RPTPbeta	116,124	tyrosine	RPTPbeta	CHEBI:18186	5803	Chemical	Gene	beta|amod|START_ENTITY beta|appos|END_ENTITY	Glial_tumor cell adhesion is mediated by binding of the FNIII domain of receptor protein tyrosine phosphatase beta -LRB- RPTPbeta -RRB- to tenascin_C .
22851429	0	tyrosine	22,30	RPTPs	45,50	tyrosine	RPTPs	CHEBI:18186	5802	Chemical	Gene	phosphatases|compound|START_ENTITY phosphatases|appos|END_ENTITY	Receptor type protein tyrosine phosphatases -LRB- RPTPs -RRB- - roles in signal transduction and human disease .
17785202	0	tyrosine	69,77	RSK2	97,101	tyrosine	RSK2	CHEBI:18186	6197	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway .
20100835	0	tyrosine	35,43	RUNX3	26,31	tyrosine	RUNX3	CHEBI:18186	12399(Tax:10090)	Chemical	Gene	residues|amod|START_ENTITY END_ENTITY|nmod|residues	Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm .
10209253	0	tyrosine	23,31	RYK	39,42	tyrosine	RYK	CHEBI:18186	140585(Tax:10116)	Chemical	Gene	Expression|nmod|START_ENTITY kinase|nsubj|Expression kinase|dobj|END_ENTITY	Expression of receptor tyrosine kinase RYK in developing rat central nervous system .
11956217	0	tyrosine	39,47	RYK	0,3	tyrosine	RYK	CHEBI:18186	6259	Chemical	Gene	kinase|compound|START_ENTITY END_ENTITY|appos|kinase	RYK , a catalytically inactive receptor tyrosine kinase , associates with EphB2 and EphB3 but does not interact with AF-6 .
8386829	0	tyrosine	95,103	RYK	113,116	tyrosine	RYK	CHEBI:18186	6259	Chemical	Gene	kinases|amod|START_ENTITY kinases|appos|END_ENTITY	Molecular cloning and chromosomal localisation of the human homologue of a receptor related to tyrosine kinases -LRB- RYK -RRB- .
22683472	0	tyrosine	23,31	Rab5	52,56	tyrosine	Rab5	CHEBI:18186	5868	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|nmod|END_ENTITY	Effect of EGF-receptor tyrosine kinase inhibitor on Rab5 function during endocytosis .
11716471	0	tyrosine	32,40	Raf-1	26,31	tyrosine	Raf-1	CHEBI:18186	5894	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Erythropoietin-stimulated Raf-1 tyrosine phosphorylation is associated with the tyrosine kinase Lyn in J2E erythroleukemic cells .
12569567	0	tyrosine	69,77	Rak	65,68	tyrosine	Rak	CHEBI:18186	2444	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Breast_cancer cell line proliferation blocked by the Src-related Rak tyrosine kinase .
7696183	0	tyrosine	21,29	Rak	0,3	tyrosine	Rak	CHEBI:18186	2444	Chemical	Gene	kinase|compound|START_ENTITY END_ENTITY|appos|kinase	Rak , a novel nuclear tyrosine kinase expressed in epithelial cells .
15513915	0	tyrosine	23,31	Ras_guanine-releasing_factor_1	51,81	tyrosine	Ras guanine-releasing factor 1	CHEBI:18186	192213(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Neurotrophin-dependent tyrosine phosphorylation of Ras_guanine-releasing_factor_1 and associated neurite outgrowth is dependent on the HIKE domain of TrkA .
10068485	0	tyrosine	41,49	Rek	0,3	tyrosine	Rek	CHEBI:18186	395336(Tax:9031)	Chemical	Gene	kinase|compound|START_ENTITY END_ENTITY|appos|kinase	Rek , an Axl/Tyro3-related receptor-class tyrosine kinase , is expressed in M ller glia and differentiating neural subpopulations in the avian retina .
8543063	0	tyrosine	30,38	Rep	54,57	tyrosine	Rep	CHEBI:18186	949141(Tax:10832)	Chemical	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	Identification of the nicking tyrosine of geminivirus Rep protein .
10208419	0	tyrosine	31,39	Ret	115,118	tyrosine	Ret	CHEBI:18186	5979	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|focal_adhesion_kinase focal_adhesion_kinase|acl|mediated mediated|nmod|END_ENTITY	Rho-dependent and - independent tyrosine phosphorylation of focal_adhesion_kinase , paxillin and p130Cas mediated by Ret kinase .
10637293	0	tyrosine	100,108	Ret	96,99	tyrosine	Ret	CHEBI:18186	5979	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Ultraviolet light induces redox reaction-mediated dimerization and superactivation of oncogenic Ret tyrosine kinases .
11564708	0	tyrosine	51,59	Ret	14,17	tyrosine	Ret	CHEBI:18186	5979	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|activity activity|compound|END_ENTITY	Inhibition of Ret oncogene activity by the protein tyrosine phosphatase SHP1 .
12959980	0	tyrosine	4,12	Ret	77,80	tyrosine	Ret	CHEBI:18186	24716(Tax:10116)	Chemical	Gene	Shp-2|amod|START_ENTITY mediates|nsubj|Shp-2 mediates|dobj|intracellular intracellular|acl|signaling signaling|dep|initiated initiated|nmod|mutants mutants|compound|END_ENTITY	The tyrosine phosphatase Shp-2 mediates intracellular signaling initiated by Ret mutants .
15115663	0	tyrosine	21,29	Ret	121,124	tyrosine	Ret	CHEBI:18186	24716(Tax:10116)	Chemical	Gene	phosphatases|amod|START_ENTITY Shp-1|appos|phosphatases recruited|nsubjpass|Shp-1 recruited|nmod|complexes complexes|nmod|oncogenes oncogenes|compound|END_ENTITY	The Shp-1 and Shp-2 , tyrosine phosphatases , are recruited on cell membrane in two distinct molecular complexes including Ret oncogenes .
15340065	0	tyrosine	24,32	Ret	41,44	tyrosine	Ret	CHEBI:18186	19713(Tax:10090)	Chemical	Gene	1062|amod|START_ENTITY mutation|nmod|1062 mutation|nmod|END_ENTITY	A targeting mutation of tyrosine 1062 in Ret causes a marked decrease_of_enteric_neurons and renal_hypoplasia .
15569713	0	tyrosine	96,104	Ret	112,115	tyrosine	Ret	CHEBI:18186	5979	Chemical	Gene	function|nmod|START_ENTITY kinase|nsubj|function kinase|dobj|END_ENTITY	The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cells .
17050626	0	tyrosine	43,51	Ret	39,42	tyrosine	Ret	CHEBI:18186	19713(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Targeted mutation of serine 697 in the Ret tyrosine kinase causes migration_defect_of_enteric_neural_crest cells .
18171921	0	tyrosine	49,57	Ret	36,39	tyrosine	Ret	CHEBI:18186	5979	Chemical	Gene	activation|compound|START_ENTITY activation|amod|END_ENTITY	Lrig1 is an endogenous inhibitor of Ret receptor tyrosine kinase activation , downstream signaling , and biological responses to GDNF .
18171921	3	tyrosine	609,617	Ret	596,599	tyrosine	Ret	CHEBI:18186	5979	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Here , we show that Lrig1 , a transmembrane protein containing leucine-rich repeats and Ig-like domains in its extracellular region , acts in a negative feedback loop to regulate the activity of Ret receptor tyrosine kinase .
18483257	0	tyrosine	17,25	Ret	4,7	tyrosine	Ret	CHEBI:18186	5979	Chemical	Gene	START_ENTITY|nsubj|receptor receptor|compound|END_ENTITY	The Ret receptor tyrosine kinase pathway functionally interacts with the ERalpha pathway in breast_cancer .
19107952	0	tyrosine	48,56	Ret	64,67	tyrosine	Ret	CHEBI:18186	24716(Tax:10116)	Chemical	Gene	kinase|amod|START_ENTITY inhibition|amod|kinase inhibition|compound|END_ENTITY	Developmental toxicity associated with receptor tyrosine kinase Ret inhibition in reproductive toxicity testing .
7665556	0	tyrosine	25,33	Ret	4,7	tyrosine	Ret	CHEBI:18186	5979	Chemical	Gene	START_ENTITY|nsubj|protein protein|compound|END_ENTITY	The Ret receptor protein tyrosine kinase associates with the SH2-containing adapter protein Grb10 .
8570170	0	tyrosine	13,21	Ret	0,3	tyrosine	Ret	CHEBI:18186	5979	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Ret receptor tyrosine kinase activates extracellular_signal-regulated_kinase_2 in SK-N-MC cells .
8631863	0	tyrosine	44,52	Ret	31,34	tyrosine	Ret	CHEBI:18186	5979	Chemical	Gene	START_ENTITY|nsubj|association association|nmod|receptor receptor|compound|END_ENTITY	Direct association between the Ret receptor tyrosine kinase and the Src homology 2-containing adapter protein Grb7 .
8657282	0	tyrosine	41,49	Ret	28,31	tyrosine	Ret	CHEBI:18186	5979	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	GDNF signalling through the Ret receptor tyrosine kinase .
9047384	0	tyrosine	42,50	Ret	38,41	tyrosine	Ret	CHEBI:18186	5979	Chemical	Gene	START_ENTITY|nsubj|Identification Identification|nmod|site site|nmod|END_ENTITY	Identification of Shc docking site on Ret tyrosine kinase .
9121763	0	tyrosine	86,94	Ret	65,68	tyrosine	Ret	CHEBI:18186	5979	Chemical	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Cell scattering of SK-N-MC neuroepithelioma cells in response to Ret and FGF receptor tyrosine kinase activation is correlated with sustained ERK2 activation .
9393871	0	tyrosine	92,100	Ret	88,91	tyrosine	Ret	CHEBI:18186	5979	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The multiple_endocrine_neoplasia_type_2B point mutation switches the specificity of the Ret tyrosine kinase towards cellular substrates that are susceptible to interact with Crk and Nck .
9764818	0	tyrosine	46,54	Ret	42,45	tyrosine	Ret	CHEBI:18186	5979	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Grb2 binding to the different isoforms of Ret tyrosine kinase .
10528237	0	tyrosine	65,73	Ron	26,29	tyrosine	Ron	CHEBI:18186	19882(Tax:10090)	Chemical	Gene	activity|amod|START_ENTITY upregulation|nmod|activity mutations|nmod|upregulation mutations|nmod|result result|compound|END_ENTITY	MET -LRB- PRC -RRB- mutations in the Ron receptor result in upregulation of tyrosine kinase activity and acquisition of oncogenic potential .
11751209	0	tyrosine	25,33	Ron	41,44	tyrosine	Ron	CHEBI:18186	19882(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY kinase|nsubj|role kinase|dobj|END_ENTITY	The role of the receptor tyrosine kinase Ron in nickel-induced acute_lung_injury .
12395314	0	tyrosine	29,37	Ron	16,19	tyrosine	Ron	CHEBI:18186	19882(Tax:10090)	Chemical	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	Deletion of the Ron receptor tyrosine kinase domain in mice provides protection from endotoxin-induced acute_liver_failure .
12802274	0	tyrosine	41,49	Ron	37,40	tyrosine	Ron	CHEBI:18186	4486	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	c-Cbl is a critical modulator of the Ron tyrosine kinase receptor .
14499632	0	tyrosine	32,40	Ron	49,52	tyrosine	Ron	CHEBI:18186	19882(Tax:10090)	Chemical	Gene	Cross-talk|nmod|START_ENTITY kinases|nsubj|Cross-talk kinases|dobj|END_ENTITY	Cross-talk between the receptor tyrosine kinases Ron and epidermal_growth_factor_receptor .
14505749	0	tyrosine	13,21	Ron	29,32	tyrosine	Ron	CHEBI:18186	19882(Tax:10090)	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|ccomp|expressed expressed|nsubjpass|END_ENTITY	The receptor tyrosine kinase Ron is expressed in the mouse ovary and regulates inducible_nitric_oxide_synthase levels and ovulation .
15531916	0	tyrosine	4,12	Ron	0,3	tyrosine	Ron	CHEBI:18186	19882(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Ron tyrosine kinase receptor regulates papilloma growth and malignant conversion in a murine model of skin_carcinogenesis .
18434891	0	tyrosine	13,21	Ron	0,3	tyrosine	Ron	CHEBI:18186	19882(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|receptor receptor|compound|END_ENTITY	Ron receptor tyrosine kinase-dependent hepatic neutrophil recruitment and survival benefit in a murine model of bacterial_peritonitis .
18620091	0	tyrosine	21,29	Ron	37,40	tyrosine	Ron	CHEBI:18186	4486	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|dobj|END_ENTITY	Met-related receptor tyrosine kinase Ron in tumor growth and metastasis .
19452510	0	tyrosine	17,25	Ron	4,7	tyrosine	Ron	CHEBI:18186	19882(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The Ron receptor tyrosine kinase is not required for adenoma formation in Apc -LRB- Min / + -RRB- mice .
19487969	0	tyrosine	13,21	Ron	0,3	tyrosine	Ron	CHEBI:18186	19882(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Ron receptor tyrosine kinase negatively regulates TNFalpha production in alveolar macrophages by inhibiting NF-kappaB activity and Adam17 production .
19576199	0	tyrosine	17,25	Ron	4,7	tyrosine	Ron	CHEBI:18186	19882(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The Ron receptor tyrosine kinase negatively regulates mammary gland branching morphogenesis .
19838218	0	tyrosine	17,25	Ron	4,7	tyrosine	Ron	CHEBI:18186	4486	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The Ron receptor tyrosine kinase positively regulates angiogenic chemokine production in prostate_cancer cells .
21810604	0	tyrosine	82,90	Ron	69,72	tyrosine	Ron	CHEBI:18186	19882(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Regulation of macrophage arginase expression and tumor growth by the Ron receptor tyrosine kinase .
23542172	0	tyrosine	17,25	Ron	4,7	tyrosine	Ron	CHEBI:18186	4486	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The Ron receptor tyrosine kinase activates c-Abl to promote cell proliferation through tyrosine phosphorylation of PCNA in breast_cancer .
23542172	0	tyrosine	87,95	Ron	4,7	tyrosine	Ron	CHEBI:18186	4486	Chemical	Gene	phosphorylation|amod|START_ENTITY promote|nmod|phosphorylation activates|advcl|promote activates|nsubj|kinase kinase|compound|END_ENTITY	The Ron receptor tyrosine kinase activates c-Abl to promote cell proliferation through tyrosine phosphorylation of PCNA in breast_cancer .
8730094	0	tyrosine	4,12	Ron	30,33	tyrosine	Ron	CHEBI:18186	4486	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|ccomp|control control|nsubj|END_ENTITY	The tyrosine kinase receptors Ron and Sea control `` scattering '' and morphogenesis of liver progenitor cells in vitro .
9715276	0	tyrosine	23,31	Ron	100,103	tyrosine	Ron	CHEBI:18186	4486	Chemical	Gene	domain|amod|START_ENTITY mutations|nmod|domain release|nsubj|mutations release|dobj|potential potential|nmod|receptor receptor|compound|END_ENTITY	Point mutations in the tyrosine kinase domain release the oncogenic and metastatic potential of the Ron receptor .
11846036	0	tyrosine	17,25	Ror	4,7	tyrosine	Ror	CHEBI:18186	100885779	Chemical	Gene	START_ENTITY|nsubj|receptor receptor|compound|END_ENTITY	The Ror receptor tyrosine kinase family .
12898527	0	tyrosine	47,55	Ror	43,46	tyrosine	Ror	CHEBI:18186	100885779	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Expression and subcellular localization of Ror tyrosine kinase receptors are developmentally regulated in cultured hippocampal neurons .
15095375	0	tyrosine	45,53	Ror	41,44	tyrosine	Ror	CHEBI:18186	100885779	Chemical	Gene	START_ENTITY|nsubj|localization localization|nmod|END_ENTITY	Differential subcellular localization of Ror tyrosine kinase receptors in cultured astrocytes .
11455430	0	tyrosine	41,49	Ror1	18,22	tyrosine	Ror1	CHEBI:18186	26563(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of the Ror1 and Ror2 receptor tyrosine kinase genes during mouse development .
15654020	0	tyrosine	68,76	Ror1	85,89	tyrosine	Ror1	CHEBI:18186	4919	Chemical	Gene	role|nmod|START_ENTITY neurons|dep|role extension|nmod|neurons kinases|nsubj|extension kinases|dobj|END_ENTITY	Neurite extension in central neurons : a novel role for the receptor tyrosine kinases Ror1 and Ror2 .
18546292	0	tyrosine	30,38	Ror1	0,4	tyrosine	Ror1	CHEBI:18186	4919	Chemical	Gene	kinase|amod|START_ENTITY receptor|amod|kinase expressed|nsubjpass|receptor expressed|advmod|END_ENTITY	Ror1 , a cell surface receptor tyrosine kinase is expressed in chronic_lymphocytic_leukemia and may serve as a putative target for therapy .
8875995	0	tyrosine	55,63	Ror1	41,45	tyrosine	Ror1	CHEBI:18186	4919	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Human neural tissues express a truncated Ror1 receptor tyrosine kinase , lacking both extracellular and transmembrane domains .
10700181	0	tyrosine	31,39	Ror2	0,4	tyrosine	Ror2	CHEBI:18186	26564(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY encoding|dobj|kinase required|advcl|encoding required|nsubjpass|END_ENTITY	Ror2 , encoding a receptor-like tyrosine kinase , is required for cartilage and growth plate development .
12754255	0	tyrosine	13,21	Ror2	29,33	tyrosine	Ror2	CHEBI:18186	4920	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|dobj|associates associates|amod|END_ENTITY	The receptor tyrosine kinase Ror2 associates with the melanoma-associated_antigen -LRB- MAGE -RRB- family protein Dlxin-1 and regulates its intracellular distribution .
12839624	0	tyrosine	13,21	Ror2	29,33	tyrosine	Ror2	CHEBI:18186	26564(Tax:10090)	Chemical	Gene	START_ENTITY|ccomp|involved involved|nsubjpass|END_ENTITY	The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway .
15375164	0	tyrosine	13,21	Ror2	29,33	tyrosine	Ror2	CHEBI:18186	4920	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|dobj|associates associates|amod|END_ENTITY	The receptor tyrosine kinase Ror2 associates with and is activated by casein_kinase_Iepsilon .
15388793	0	tyrosine	20,28	Ror2	36,40	tyrosine	Ror2	CHEBI:18186	4920	Chemical	Gene	START_ENTITY|ccomp|modulates modulates|nsubj|END_ENTITY	The orphan receptor tyrosine kinase Ror2 modulates canonical Wnt signaling in osteoblastic cells .
15569154	0	tyrosine	65,73	Ror2	90,94	tyrosine	Ror2	CHEBI:18186	26564(Tax:10090)	Chemical	Gene	signalling|nmod|START_ENTITY GDF5/BRI-b|acl|signalling Modulation|nmod|GDF5/BRI-b kinase|nsubj|Modulation kinase|dobj|END_ENTITY	Modulation of GDF5/BRI-b signalling through interaction with the tyrosine kinase receptor Ror2 .
17717073	0	tyrosine	25,33	Ror2	20,24	tyrosine	Ror2	CHEBI:18186	4920	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Homodimerization of Ror2 tyrosine kinase receptor induces 14-3-3 -LRB- beta -RRB- phosphorylation and promotes osteoblast differentiation and bone formation .
18615587	0	tyrosine	63,71	Ror2	49,53	tyrosine	Ror2	CHEBI:18186	4920	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Wnt5a induces homodimerization and activation of Ror2 receptor tyrosine kinase .
18762249	0	tyrosine	89,97	Ror2	105,109	tyrosine	Ror2	CHEBI:18186	4920	Chemical	Gene	START_ENTITY|ccomp|modulates modulates|nsubj|END_ENTITY	Wnt-ligand-dependent interaction of TAK1 -LRB- TGF-beta-activated_kinase-1 -RRB- with the receptor tyrosine kinase Ror2 modulates canonical Wnt-signalling .
18762249	1	tyrosine	172,180	Ror2	188,192	tyrosine	TAK1	CHEBI:18186	6885	Chemical	Gene	Mutations|nmod|START_ENTITY kinase|nsubj|Mutations kinase|dobj|account account|amod|END_ENTITY	Mutations in the receptor tyrosine kinase Ror2 account for Brachydactyly_type_B_and_Robinow_Syndrome .
19720827	0	tyrosine	23,31	Ror2	0,4	tyrosine	Ror2	CHEBI:18186	26564(Tax:10090)	Chemical	Gene	activity|amod|START_ENTITY requires|dobj|activity requires|nsubj|receptor receptor|amod|END_ENTITY	Ror2 receptor requires tyrosine kinase activity to mediate Wnt5A signaling .
10066802	0	tyrosine	80,88	Ryk	98,101	tyrosine	Ryk	CHEBI:18186	20187(Tax:10090)	Chemical	Gene	kinases|amod|START_ENTITY kinases|appos|END_ENTITY	Genomic structure and expression of the mouse growth factor receptor related to tyrosine kinases -LRB- Ryk -RRB- .
24370848	0	tyrosine	33,41	Ryk	12,15	tyrosine	Ryk	CHEBI:18186	6259	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	The role of Ryk and Ror receptor tyrosine kinases in Wnt signal transduction .
19170756	0	tyrosine	40,48	SAP-1	0,5	tyrosine	SAP-1	CHEBI:18186	545902(Tax:10090)	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|nsubj|END_ENTITY	SAP-1 is a microvillus-specific protein tyrosine phosphatase that modulates intestinal tumorigenesis .
12242023	6	tyrosine	734,742	SB_203580	950,959	tyrosine	NF-kappaB	CHEBI:18186	18033(Tax:10090)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	The tyrosine kinase inhibitor , genistein , the phosphatidylinositol-3-kinase -LRB- PI_3-K -RRB- inhibitor , LY_294002 , the protein kinase C -LRB- PKC -RRB- inhibitor , Ro_31-8220 , and the p38 mitogen-activated protein kinase -LRB- MAPK -RRB- inhibitor , SB_203580 , all inhibited AGEs-stimulated iNOS expression , NO release , NF-kappaB translocation and NF-kappaB DNA binding activity .
21414922	0	tyrosine	119,127	SCD-2	136,141	tyrosine	SCD-2	CHEBI:18186	179054(Tax:6239)	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	Behavioral choice between conflicting alternatives is regulated by a receptor guanylyl cyclase , GCY-28 , and a receptor tyrosine kinase , SCD-2 , in AIA interneurons of Caenorhabditis_elegans .
7512933	0	tyrosine	43,51	SH-PTP1	65,72	tyrosine	SH-PTP1	CHEBI:18186	5777	Chemical	Gene	START_ENTITY|dobj|phosphatase phosphatase|appos|END_ENTITY	Translocation of an SH2-containing protein tyrosine phosphatase -LRB- SH-PTP1 -RRB- to the cytoskeleton of thrombin-activated platelets .
8183573	0	tyrosine	46,54	SH-PTP3	68,75	tyrosine	SH-PTP3	CHEBI:18186	5781	Chemical	Gene	START_ENTITY|dobj|gene gene|appos|END_ENTITY	Chromosomal localization of an SH2 containing tyrosine phosphatase -LRB- SH-PTP3 -RRB- gene to chromosome 12q24 .1 .
10499514	0	tyrosine	55,63	SH2-containing_inositol_phosphatase	89,124	tyrosine	SH2-containing inositol phosphatase	CHEBI:18186	3635	Chemical	Gene	sites|compound|START_ENTITY sites|nmod|END_ENTITY	Role of the Src homology 2 -LRB- SH2 -RRB- domain and C-terminus tyrosine phosphorylation sites of SH2-containing_inositol_phosphatase -LRB- SHIP -RRB- in the regulation of insulin-induced mitogenesis .
11997181	0	tyrosine	20,28	SHC	48,51	tyrosine	SHC	CHEBI:18186	6464	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|proteins proteins|compound|END_ENTITY	Leptin promotes the tyrosine phosphorylation of SHC proteins and SHC association with GRB2 .
7681824	0	tyrosine	39,47	SHC	67,70	tyrosine	SHC	CHEBI:18186	20416(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Epidermal_growth_factor stimulates the tyrosine phosphorylation of SHC in the mouse .
8290264	0	tyrosine	39,47	SHC	23,26	tyrosine	SHC	CHEBI:18186	6464	Chemical	Gene	proteins|nmod|START_ENTITY proteins|compound|END_ENTITY	Phosphorylation of the SHC proteins on tyrosine correlates with the transformation of fibroblasts and erythroblasts by the v-sea tyrosine kinase .
9083021	0	tyrosine	95,103	SHIP	123,127	tyrosine	SHIP	CHEBI:18186	16331(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	The Src homology 2 -LRB- SH2 -RRB- domain of SH2-containing_inositol_phosphatase -LRB- SHIP -RRB- is essential for tyrosine phosphorylation of SHIP , its association with Shc , and its induction of apoptosis .
17219406	0	tyrosine	36,44	SHIP2	30,35	tyrosine	SHIP2	CHEBI:18186	3636	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of PDGF-stimulated SHIP2 tyrosine phosphorylation and association with Shc in 3T3-L1 preadipocytes .
16814162	0	tyrosine	12,20	SHP	0,3	tyrosine	SHP	CHEBI:18186	117274(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|protein protein|compound|END_ENTITY	SHP protein tyrosine phosphatase expression in rat uterine tissue .
10378893	0	tyrosine	23,31	SHP-1	45,50	tyrosine	SHP-1	CHEBI:18186	8431	Chemical	Gene	phosphatases|compound|START_ENTITY phosphatases|amod|END_ENTITY	SH2-containing protein tyrosine phosphatases SHP-1 and SHP-2 are dramatically increased at the protein level in neutrophils from patients with severe congenital_neutropenia -LRB- Kostmann 's _ syndrome -RRB- .
10540344	0	tyrosine	117,125	SHP-1	103,108	tyrosine	SHP-1	CHEBI:18186	5777	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|compound|END_ENTITY	Negative regulation of antigen receptor-mediated signaling by constitutive association of CD5 with the SHP-1 protein tyrosine phosphatase in B-1 B cells .
10585470	0	tyrosine	29,37	SHP-1	0,5	tyrosine	SHP-1	CHEBI:18186	5777	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|compound|END_ENTITY	SHP-1 regulation of p62 -LRB- DOK -RRB- tyrosine phosphorylation in macrophages .
10660620	0	tyrosine	103,111	SHP-1	92,97	tyrosine	SHP-1	CHEBI:18186	5777	Chemical	Gene	phosphorylation|amod|START_ENTITY recruits|nmod|phosphorylation recruits|dobj|END_ENTITY	PILRalpha , a novel immunoreceptor tyrosine-based inhibitory motif-bearing protein , recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILRbeta .
10764762	0	tyrosine	108,116	SHP-1	129,134	tyrosine	SHP-1	CHEBI:18186	5777	Chemical	Gene	phosphatase|amod|START_ENTITY protein|nmod|phosphatase leukocyte-associated_Ig-like_receptor-1|nmod|protein END_ENTITY|amod|leukocyte-associated_Ig-like_receptor-1	Identification and characterization of leukocyte-associated_Ig-like_receptor-1 as a major anchor protein of tyrosine phosphatase SHP-1 in hematopoietic cells .
10781410	0	tyrosine	20,28	SHP-1	42,47	tyrosine	SHP-1	CHEBI:18186	5777	Chemical	Gene	phosphatases|compound|START_ENTITY phosphatases|amod|END_ENTITY	Cytoplasmic protein tyrosine phosphatases SHP-1 and SHP-2 : regulators of B cell signal transduction .
10849365	0	tyrosine	29,37	SHP-1	15,20	tyrosine	SHP-1	CHEBI:18186	5777	Chemical	Gene	START_ENTITY|nsubj|Recruitment Recruitment|nmod|protein protein|compound|END_ENTITY	Recruitment of SHP-1 protein tyrosine phosphatase and signalling by a chimeric T-cell receptor-killer inhibitory receptor .
11171044	0	tyrosine	155,163	SHP-1	177,182	tyrosine	SHP-1	CHEBI:18186	19261(Tax:10090)	Chemical	Gene	phosphatases|compound|START_ENTITY phosphatases|amod|END_ENTITY	mSiglec-E , a novel mouse CD33-related siglec -LRB- sialic_acid-binding immunoglobulin-like lectin -RRB- that recruits Src homology 2 -LRB- SH2 -RRB- - domain-containing protein tyrosine phosphatases SHP-1 and SHP-2 .
11294838	0	tyrosine	38,46	SHP-1	80,85	tyrosine	SHP-1	CHEBI:18186	15170(Tax:10090)	Chemical	Gene	protein|compound|START_ENTITY dephosphorylation|nmod|protein kinase|nsubj|dephosphorylation kinase|nmod|phosphatase phosphatase|compound|END_ENTITY	Specific dephosphorylation of the Lck tyrosine protein kinase at Tyr-394 by the SHP-1 protein-tyrosine phosphatase .
11302725	0	tyrosine	105,113	SHP-1	99,104	tyrosine	SHP-1	CHEBI:18186	15170(Tax:10090)	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Effect of angiotensin_II_type_2_receptor on tyrosine kinase Pyk2 and c-Jun_NH2-terminal_kinase via SHP-1 tyrosine phosphatase activity : evidence from vascular-targeted transgenic_mice of AT2_receptor .
11566906	0	tyrosine	124,132	SHP-1	118,123	tyrosine	SHP-1	CHEBI:18186	15170(Tax:10090)	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|compound|END_ENTITY	Angiotensin_II_type_2_receptor inhibits epidermal_growth_factor_receptor transactivation by increasing association of SHP-1 tyrosine phosphatase .
11583976	0	tyrosine	41,49	SHP-1	62,67	tyrosine	SHP-1	CHEBI:18186	5777	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Reduction of hematopoietic cell-specific tyrosine phosphatase SHP-1 gene expression in natural killer cell lymphoma and various types of lymphomas/leukemias : combination analysis with cDNA expression array and tissue microarray .
11745639	0	tyrosine	20,28	SHP-1	41,46	tyrosine	SHP-1	CHEBI:18186	15170(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|results results|compound|END_ENTITY	Lack of the protein tyrosine phosphatase SHP-1 results in decreased numbers of glia within the motheaten -LRB- me/me -RRB- mouse brain .
11835408	0	tyrosine	33,41	SHP-1	80,85	tyrosine	SHP-1	CHEBI:18186	5777	Chemical	Gene	phosphatase|compound|START_ENTITY specificity|nmod|phosphatase specificity|dep|behavior behavior|nmod|END_ENTITY	Substrate specificity of protein tyrosine phosphatase : differential behavior of SHP-1 and SHP-2 towards signal regulation protein SIRPalpha1 .
12361947	0	tyrosine	40,48	SHP-1	62,67	tyrosine	SHP-1	CHEBI:18186	5777	Chemical	Gene	phosphatase|amod|START_ENTITY +|nmod|phosphatase +|xcomp|END_ENTITY	Modulation of the ERG K + current by the tyrosine phosphatase , SHP-1 .
12468540	0	tyrosine	23,31	SHP-1	69,74	tyrosine	SHP-1	CHEBI:18186	5777	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|regulation regulation|nmod|END_ENTITY	The role of C-terminal tyrosine phosphorylation in the regulation of SHP-1 explored via expressed protein ligation .
12644021	0	tyrosine	38,46	SHP-1	24,29	tyrosine	SHP-1	CHEBI:18186	15170(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Mechanisms Mechanisms|nmod|anemia anemia|nmod|protein protein|compound|END_ENTITY	Mechanisms of anemia in SHP-1 protein tyrosine phosphatase-deficient `` viable motheaten '' mice .
14652006	0	tyrosine	148,156	SHP-1	170,175	tyrosine	SHP-1	CHEBI:18186	8431	Chemical	Gene	phosphatases|compound|START_ENTITY phosphatases|amod|END_ENTITY	Characterization of phosphotyrosine binding motifs in the cytoplasmic domain of B_and_T_lymphocyte_attenuator required for association with protein tyrosine phosphatases SHP-1 and SHP-2 .
15068587	0	tyrosine	23,31	SHP-1	44,49	tyrosine	SHP-1	CHEBI:18186	5777	Chemical	Gene	ability|nmod|START_ENTITY phosphatase|nsubj|ability phosphatase|xcomp|END_ENTITY	The ability of protein tyrosine phosphatase SHP-1 to suppress NFkappaB can be inhibited by dominant negative mutant of SIRPalpha .
15870198	0	tyrosine	74,82	SHP-1	68,73	tyrosine	SHP-1	CHEBI:18186	5777	Chemical	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	STAT3 - and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes .
15893190	0	tyrosine	4,12	SHP-1	26,31	tyrosine	SHP-1	CHEBI:18186	5777	Chemical	Gene	phosphatase|amod|START_ENTITY phosphatase|appos|END_ENTITY	The tyrosine phosphatase , SHP-1 , is a negative regulator of endothelial superoxide formation .
16084691	0	tyrosine	65,73	SHP-1	49,54	tyrosine	SHP-1	CHEBI:18186	5777	Chemical	Gene	phosphatases|compound|START_ENTITY phosphatases|amod|END_ENTITY	A SHPing tale : perspectives on the regulation of SHP-1 and SHP-2 tyrosine phosphatases by the C-terminal tail .
16617349	0	tyrosine	18,26	SHP-1	4,9	tyrosine	SHP-1	CHEBI:18186	15170(Tax:10090)	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|compound|END_ENTITY	The SHP-1 protein tyrosine phosphatase negatively modulates glucose homeostasis .
16762922	1	tyrosine	33,41	SHP-1	55,60	tyrosine	SHP-1	CHEBI:18186	5777	Chemical	Gene	Role|nmod|START_ENTITY phosphatases|nsubj|Role phosphatases|xcomp|END_ENTITY	Role of tyrosine phosphatases SHP-1 and SHP-2 in growth factor signaling .
16898954	0	tyrosine	47,55	SHP-1	93,98	tyrosine	SHP-1	CHEBI:18186	5777	Chemical	Gene	dephosphorylation|amod|START_ENTITY dephosphorylation|dep|role role|nmod|phosphatase phosphatase|compound|END_ENTITY	Platelet nitric_oxide synthase is activated by tyrosine dephosphorylation : possible role for SHP-1 phosphatase .
17239936	0	tyrosine	14,22	SHP-1	8,13	tyrosine	SHP-1	CHEBI:18186	5777	Chemical	Gene	START_ENTITY|nsubj|Loss Loss|nmod|END_ENTITY	Loss of SHP-1 tyrosine phosphatase expression correlates with the advanced stages of cutaneous_T-cell_lymphoma .
17522256	0	tyrosine	56,64	SHP-1	50,55	tyrosine	SHP-1	CHEBI:18186	5777	Chemical	Gene	START_ENTITY|nsubj|B_cell_activation B_cell_activation|nmod|END_ENTITY	Fc_receptor-like_5 inhibits B_cell_activation via SHP-1 tyrosine phosphatase recruitment .
17647198	0	tyrosine	26,34	SHP-1	48,53	tyrosine	SHP-1	CHEBI:18186	5777	Chemical	Gene	phosphatases|nsubj|START_ENTITY phosphatases|xcomp|END_ENTITY	The Src homology 2 domain tyrosine phosphatases SHP-1 and SHP-2 : diversified control of cell growth , inflammation , and injury .
18377662	0	tyrosine	47,55	SHP-1	71,76	tyrosine	SHP-1	CHEBI:18186	5777	Chemical	Gene	phosphatase-1|amod|START_ENTITY protein|amod|phosphatase-1 protein|appos|END_ENTITY	Src homology 2 -LRB- SH2 -RRB- domain containing protein tyrosine phosphatase-1 -LRB- SHP-1 -RRB- dephosphorylates VEGF Receptor-2 and attenuates endothelial DNA synthesis , but not migration * .
18793215	0	tyrosine	64,72	SHP-1	138,143	tyrosine	SHP-1	CHEBI:18186	15170(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|Src_homology_2_domain_phosphotyrosine_phosphatase_1 Src_homology_2_domain_phosphotyrosine_phosphatase_1|appos|END_ENTITY	Regulation of macrophage nitric_oxide production by the protein tyrosine phosphatase Src_homology_2_domain_phosphotyrosine_phosphatase_1 -LRB- SHP-1 -RRB- .
19749791	0	tyrosine	52,60	SHP-1	14,19	tyrosine	SHP-1	CHEBI:18186	8431	Chemical	Gene	phosphorylation|compound|START_ENTITY leads|nmod|phosphorylation leads|nsubj|Repression Repression|nmod|expression expression|compound|END_ENTITY	Repression of SHP-1 expression by p53 leads to trkA tyrosine phosphorylation and suppression of breast_cancer cell proliferation .
19789387	0	tyrosine	8,16	SHP-1	29,34	tyrosine	SHP-1	CHEBI:18186	15170(Tax:10090)	Chemical	Gene	Role|nmod|START_ENTITY phosphatase|nsubj|Role phosphatase|dobj|END_ENTITY	Role of tyrosine phosphatase SHP-1 in the mechanism of endorepellin angiostatic activity .
20068065	0	tyrosine	127,135	SHP-1	149,154	tyrosine	SHP-1	CHEBI:18186	5777	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|appos|END_ENTITY	5-hydroxy-2-methyl-1 ,4 - naphthoquinone , a vitamin_K3 analogue , suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase , SHP-1 : potential role in chemosensitization .
20117097	0	tyrosine	4,12	SHP-1	26,31	tyrosine	SHP-1	CHEBI:18186	15170(Tax:10090)	Chemical	Gene	phosphatase|amod|START_ENTITY phosphatase|appos|END_ENTITY	The tyrosine phosphatase , SHP-1 , is involved in bronchial mucin production during oxidative stress .
20351292	0	tyrosine	30,38	SHP-1	16,21	tyrosine	SHP-1	D014443	5777	Chemical	Gene	START_ENTITY|nsubj|Contribution Contribution|nmod|protein protein|compound|END_ENTITY	Contribution of SHP-1 protein tyrosine phosphatase to osmotic regulation of the transcription factor TonEBP/OREBP .
20421638	0	tyrosine	23,31	SHP-1	6,11	tyrosine	SHP-1	CHEBI:18186	15170(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|inhibitors inhibitors|compound|END_ENTITY	Novel SHP-1 inhibitors tyrosine phosphatase inhibitor-1 and analogs with preclinical anti-tumor activities as tolerated oral agents .
21900501	0	tyrosine	18,26	SHP-1	4,9	tyrosine	SHP-1	CHEBI:18186	15170(Tax:10090)	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|compound|END_ENTITY	The SHP-1 protein tyrosine phosphatase negatively modulates Akt signaling in the ghrelin/GHSR1a system .
22589543	0	tyrosine	88,96	SHP-1	110,115	tyrosine	SHP-1	CHEBI:18186	5777	Chemical	Gene	phosphatases|compound|START_ENTITY phosphatases|amod|END_ENTITY	LST1/A is a myeloid leukocyte-specific transmembrane adaptor protein recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to the plasma membrane .
22960265	0	tyrosine	14,22	SHP-1	0,5	tyrosine	SHP-1	CHEBI:18186	5777	Chemical	Gene	START_ENTITY|nsubj|protein protein|compound|END_ENTITY	SHP-1 protein tyrosine phosphatase associates with the adaptor protein CrkL .
23765383	0	tyrosine	121,129	SHP-1	107,112	tyrosine	SHP-1	CHEBI:18186	5777	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|compound|END_ENTITY	b-Caryophyllene_oxide inhibits constitutive and inducible STAT3 signaling pathway through induction of the SHP-1 protein tyrosine phosphatase .
24100145	0	tyrosine	34,42	SHP-1	20,25	tyrosine	SHP-1	CHEBI:18186	5777	Chemical	Gene	START_ENTITY|nsubj|Characterization Characterization|nmod|protein protein|compound|END_ENTITY	Characterization of SHP-1 protein tyrosine phosphatase transcripts , protein isoforms and phosphatase activity in epithelial cancer cells .
24333736	0	tyrosine	103,111	SHP-1	87,92	tyrosine	SHP-1	CHEBI:18186	5777	Chemical	Gene	phosphatases|compound|START_ENTITY phosphatases|amod|END_ENTITY	Capillarisin inhibits constitutive and inducible STAT3 activation through induction of SHP-1 and SHP-2 tyrosine phosphatases .
24587194	0	tyrosine	57,65	SHP-1	51,56	tyrosine	SHP-1	CHEBI:18186	5777	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|compound|END_ENTITY	Regulation of hERG and hEAG channels by Src and by SHP-1 tyrosine phosphatase via an ITIM region in the cyclic nucleotide binding domain .
25785436	2	tyrosine	371,379	SHP-1	393,398	tyrosine	RGS18	CHEBI:18186	64407	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|appos|END_ENTITY	This node is comprised of a scaffold protein -LRB- spinophilin , SPL -RRB- , a protein tyrosine phosphatase -LRB- SHP-1 -RRB- , and either of the two members of the Regulators of G protein Signaling family predominantly expressed in platelets -LRB- RGS10 or RGS18 -RRB- .
8943354	1	tyrosine	165,173	SHP-1	126,131	tyrosine	SHP-1	CHEBI:18186	15170(Tax:10090)	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|nsubj|END_ENTITY	SHP-1 is an SH2-containing cytoplasmic tyrosine phosphatase that is widely distributed in cells of the hematopoietic system .
9034146	0	tyrosine	126,134	SHP-1	120,125	tyrosine	SHP-1	CHEBI:18186	15170(Tax:10090)	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|compound|END_ENTITY	Mouse Ly-49A interrupts early signaling events in natural killer cell cytotoxicity and functionally associates with the SHP-1 tyrosine phosphatase .
9230127	0	tyrosine	130,138	SHP-1	124,129	tyrosine	SHP-1	CHEBI:18186	5777	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|compound|END_ENTITY	Angiotensin_II type 2 receptors mediate inhibition of mitogen-activated_protein kinase cascade and functional activation of SHP-1 tyrosine phosphatase .
9261115	2	tyrosine	381,389	SHP-1	375,380	tyrosine	SHP-1	CHEBI:18186	5777	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|compound|END_ENTITY	Herein we show that Src isolated from human platelets and Jurkat T cells is preferentially dephosphorylated at its inhibitory phosphotyrosine site by the SHP-1 tyrosine phosphatase .
9287352	0	tyrosine	42,50	SHP-1	63,68	tyrosine	SHP-1	CHEBI:18186	5777	Chemical	Gene	effects|nmod|START_ENTITY phosphatase|nsubj|effects phosphatase|xcomp|END_ENTITY	Positive effects of SH2 domain-containing tyrosine phosphatase SHP-1 on epidermal_growth_factor - and interferon-gamma-stimulated activation of STAT transcription factors in HeLa cells .
9295292	0	tyrosine	29,37	SHP-1	51,56	tyrosine	SHP-1	CHEBI:18186	5777	Chemical	Gene	titration|nmod|START_ENTITY phosphatases|nsubj|titration phosphatases|dep|using using|nsubj|END_ENTITY	Active site titration of the tyrosine phosphatases SHP-1 and PTP1B using aromatic_disulfides .
9379041	0	tyrosine	16,24	SHP-1	94,99	tyrosine	SHP-1	CHEBI:18186	116689(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphatases|nsubj|phosphorylation phosphatases|xcomp|END_ENTITY	Syk-independent tyrosine phosphorylation and association of the protein tyrosine phosphatases SHP-1 and SHP-2 with the high affinity IgE receptor .
9379041	0	tyrosine	72,80	SHP-1	94,99	tyrosine	SHP-1	CHEBI:18186	116689(Tax:10116)	Chemical	Gene	phosphorylation|nmod|START_ENTITY phosphatases|nsubj|phosphorylation phosphatases|xcomp|END_ENTITY	Syk-independent tyrosine phosphorylation and association of the protein tyrosine phosphatases SHP-1 and SHP-2 with the high affinity IgE receptor .
9422771	0	tyrosine	15,23	SHP-1	37,42	tyrosine	SHP-1	CHEBI:18186	15170(Tax:10090)	Chemical	Gene	Association|nmod|START_ENTITY phosphatases|nsubj|Association phosphatases|dobj|END_ENTITY	Association of tyrosine phosphatases SHP-1 and SHP-2 , inositol 5-phosphatase SHIP with gp49B1 , and chromosomal assignment of the gene .
9520455	0	tyrosine	38,46	SHP-1	104,109	tyrosine	SHP-1	CHEBI:18186	5777	Chemical	Gene	SHP-1|compound|START_ENTITY Recruitment|nmod|SHP-1 Recruitment|dep|loss loss|nmod|expression expression|compound|END_ENTITY	Recruitment of SH2-containing protein tyrosine phosphatase SHP-1 to the interleukin_2 receptor ; loss of SHP-1 expression in human T-lymphotropic virus type I-transformed T cells .
9590210	0	tyrosine	77,85	SHP-1	66,71	tyrosine	SHP-1	CHEBI:18186	5777	Chemical	Gene	phosphorylation|amod|START_ENTITY recruits|nmod|phosphorylation recruits|dobj|END_ENTITY	The B cell surface protein CD72 recruits the tyrosine phosphatase SHP-1 upon tyrosine phosphorylation .
9739453	0	tyrosine	31,39	SHP-1	25,30	tyrosine	SHP-1	CHEBI:18186	5777	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|END_ENTITY	Reversible regulation of SHP-1 tyrosine phosphatase activity by oxidation .
9761368	0	tyrosine	110,118	SHP-1	96,101	tyrosine	SHP-1	CHEBI:18186	15170(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Establishment Establishment|nmod|lines lines|nmod|mouse mouse|amod|defective defective|nmod|protein protein|compound|END_ENTITY	Establishment and characterization of pro-B cell lines from motheaten mutant mouse defective in SHP-1 protein tyrosine phosphatase .
9813145	5	tyrosine	552,560	SHP-1	578,583	tyrosine	SHP-1	CHEBI:18186	5777	Chemical	Gene	phosphorylation|compound|START_ENTITY inhibit|dobj|phosphorylation presence|acl|inhibit cleaved|nmod|presence cleaved|nsubjpass|END_ENTITY	In the presence of tyrphostin to inhibit thrombin-induced SHP-1 tyrosine phosphorylation , SHP-1 was cleaved .
9814969	0	tyrosine	42,50	SHP-1	77,82	tyrosine	SHP-1	CHEBI:18186	5777	Chemical	Gene	phosphorylation|compound|START_ENTITY Regulation|nmod|phosphorylation Regulation|dep|roles roles|nmod|END_ENTITY	Regulation of angiotensin_II-induced JAK2 tyrosine phosphorylation : roles of SHP-1 and SHP-2 .
9867848	0	tyrosine	66,74	SHP-1	142,147	tyrosine	SHP-1	CHEBI:18186	5777	Chemical	Gene	phosphorylation|amod|START_ENTITY controls|dobj|phosphorylation controls|nmod|phosphatases phosphatases|amod|END_ENTITY	The carboxyl-terminal region of biliary_glycoprotein controls its tyrosine phosphorylation and association with protein-tyrosine phosphatases SHP-1 and SHP-2 in epithelial cells .
11388808	0	tyrosine	120,128	SHP-2	142,147	tyrosine	SHP-2	CHEBI:18186	5781	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|appos|END_ENTITY	Construction and expression of an enzymatically active form of PECAM-1 containing the phosphatase domain of the protein tyrosine phosphatase , SHP-2 .
11684012	0	tyrosine	76,84	SHP-2	104,109	tyrosine	SHP-2	CHEBI:18186	5781	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Site-specific incorporation of a phosphotyrosine mimetic reveals a role for tyrosine phosphorylation of SHP-2 in cell signaling .
11832424	0	tyrosine	39,47	SHP-2	22,27	tyrosine	SHP-2	CHEBI:18186	19247(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|END_ENTITY	Altered regulation of SHP-2 and PTP_1B tyrosine phosphatases in cystic_kidneys from bcl-2 - / - mice .
12070037	0	tyrosine	51,59	SHP-2	45,50	tyrosine	SHP-2	CHEBI:18186	5781	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|compound|END_ENTITY	Band 3 is an anchor protein and a target for SHP-2 tyrosine phosphatase in human erythrocytes .
12955078	0	tyrosine	52,60	SHP-2	46,51	tyrosine	SHP-2	CHEBI:18186	19247(Tax:10090)	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|compound|END_ENTITY	Catalytic-dependent and - independent roles of SHP-2 tyrosine phosphatase in interleukin-3 signaling .
16963136	7	tyrosine	1234,1242	SHP-2	1262,1267	tyrosine	SHP-2	CHEBI:18186	5781	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	This interaction was transiently increased following gastrin stimulation of the CCK2R and correlated with the tyrosine phosphorylation of SHP-2 .
17027227	0	tyrosine	33,41	SHP-2	55,60	tyrosine	SHP-2	CHEBI:18186	5781	Chemical	Gene	phosphatase|amod|START_ENTITY phosphatase|appos|END_ENTITY	The N-terminal SH2 domain of the tyrosine phosphatase , SHP-2 , is essential for Jak2-dependent signaling via the angiotensin_II type AT1 receptor .
17369354	0	tyrosine	6,14	SHP-2	0,5	tyrosine	SHP-2	CHEBI:18186	19247(Tax:10090)	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|compound|END_ENTITY	SHP-2 tyrosine phosphatase inhibits p73-dependent apoptosis and expression of a subset of p53 target genes induced by EGCG .
19066472	0	tyrosine	55,63	SHP-2	21,26	tyrosine	SHP-2	CHEBI:18186	5781	Chemical	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	Tyrosine phosphatase SHP-2 is a regulator of p27 -LRB- Kip1 -RRB- tyrosine phosphorylation .
24439672	0	tyrosine	40,48	SHP-2	61,66	tyrosine	SHP-2	CHEBI:18186	5781	Chemical	Gene	significance|nmod|START_ENTITY phosphatase|nsubj|significance phosphatase|dobj|END_ENTITY	Expression and clinical significance of tyrosine phosphatase SHP-2 in colon_cancer .
9129156	0	tyrosine	22,30	SHP-2	50,55	tyrosine	SHP-2	CHEBI:18186	5781	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Interleukin-2 induces tyrosine phosphorylation of SHP-2 through IL-2_receptor beta chain .
9344856	0	tyrosine	144,152	SHP-2	105,110	tyrosine	SHP-2	CHEBI:18186	5781	Chemical	Gene	phosphatase|compound|START_ENTITY END_ENTITY|appos|phosphatase	Epidermal_growth_factor stimulates the tyrosine phosphorylation of SHPS-1 and association of SHPS-1 with SHP-2 , a SH2 domain-containing protein tyrosine phosphatase .
9344856	0	tyrosine	39,47	SHP-2	105,110	tyrosine	SHP-2	CHEBI:18186	5781	Chemical	Gene	phosphorylation|amod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nmod|END_ENTITY	Epidermal_growth_factor stimulates the tyrosine phosphorylation of SHPS-1 and association of SHPS-1 with SHP-2 , a SH2 domain-containing protein tyrosine phosphatase .
9442080	0	tyrosine	45,53	SHP-2	66,71	tyrosine	SHP-2	CHEBI:18186	19247(Tax:10090)	Chemical	Gene	Involvement|nmod|START_ENTITY phosphatase|nsubj|Involvement phosphatase|dobj|END_ENTITY	Involvement of the Src homology 2-containing tyrosine phosphatase SHP-2 in growth_hormone signaling .
9544991	0	tyrosine	40,48	SHP-2	34,39	tyrosine	SHP-2	CHEBI:18186	5781	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|compound|END_ENTITY	Dominant negative variants of the SHP-2 tyrosine phosphatase inhibit prolactin activation of Jak2 -LRB- janus_kinase_2 -RRB- and induction of Stat5 -LRB- signal_transducer_and_activator_of_transcription_5 -RRB- - dependent transcription .
9582366	0	tyrosine	18,26	SHP-2	78,83	tyrosine	SHP-2	CHEBI:18186	5781	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Integrin-mediated tyrosine phosphorylation of SHPS-1 and its association with SHP-2 .
10595583	0	tyrosine	13,21	SHP1	0,4	tyrosine	SHP1	CHEBI:18186	5777	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|compound|END_ENTITY	SHP1 protein tyrosine phosphatase negatively modulates erythroid differentiation and suppression of apoptosis in J2E erythroleukemic cells .
12438221	0	tyrosine	22,30	SHP1	43,47	tyrosine	SHP1	CHEBI:18186	5777	Chemical	Gene	silencing|nmod|START_ENTITY phosphatase|nsubj|silencing phosphatase|dobj|gene gene|compound|END_ENTITY	Gene silencing of the tyrosine phosphatase SHP1 gene by aberrant methylation in leukemias/lymphomas .
16469875	0	tyrosine	5,13	SHP1	0,4	tyrosine	SHP1	CHEBI:18186	15170(Tax:10090)	Chemical	Gene	phosphatase|amod|START_ENTITY phosphatase|nummod|END_ENTITY	SHP1 tyrosine phosphatase negatively regulates NPM-ALK tyrosine kinase signaling .
16469875	0	tyrosine	55,63	SHP1	0,4	tyrosine	SHP1	CHEBI:18186	15170(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY regulates|dobj|kinase regulates|nsubj|phosphatase phosphatase|nummod|END_ENTITY	SHP1 tyrosine phosphatase negatively regulates NPM-ALK tyrosine kinase signaling .
16871283	2	tyrosine	407,415	SHP1	399,403	tyrosine	SHP1	CHEBI:18186	5777	Chemical	Gene	phosphatase|amod|START_ENTITY END_ENTITY|appos|phosphatase	SHP1 , a tyrosine phosphatase that negatively regulates JAK/STAT , is frequently absent in ALK + ALCL owing to gene methylation .
20421975	0	tyrosine	8,16	SHP1	39,43	tyrosine	SHP1	CHEBI:18186	15170(Tax:10090)	Chemical	Gene	phosphatases|compound|START_ENTITY phosphatases|appos|TC-PTP TC-PTP|nummod|END_ENTITY	Protein tyrosine phosphatases , TC-PTP , SHP1 , and SHP2 , cooperate in rapid dephosphorylation of Stat3 in keratinocytes following UVB irradiation .
20424160	0	tyrosine	139,147	SHP1	119,123	tyrosine	SHP1	CHEBI:18186	5777	Chemical	Gene	phosphatase|compound|START_ENTITY important|dep|phosphatase important|nmod|END_ENTITY	The tyrosine 343 residue of nucleophosmin -LRB- NPM -RRB- - anaplastic lymphoma kinase -LRB- ALK -RRB- is important for its interaction with SHP1 , a cytoplasmic tyrosine phosphatase with tumor suppressor functions .
20424160	0	tyrosine	4,12	SHP1	119,123	tyrosine	SHP1	CHEBI:18186	5777	Chemical	Gene	residue|amod|START_ENTITY residue|dep|kinase kinase|acl:relcl|important important|nmod|END_ENTITY	The tyrosine 343 residue of nucleophosmin -LRB- NPM -RRB- - anaplastic lymphoma kinase -LRB- ALK -RRB- is important for its interaction with SHP1 , a cytoplasmic tyrosine phosphatase with tumor suppressor functions .
20864515	0	tyrosine	94,102	SHP1	89,93	tyrosine	SHP1	CHEBI:18186	15170(Tax:10090)	Chemical	Gene	phosphatase|amod|START_ENTITY phosphatase|compound|END_ENTITY	Prep1 controls insulin glucoregulatory function in liver by transcriptional targeting of SHP1 tyrosine phosphatase .
23279849	0	tyrosine	21,29	SHP1	116,120	tyrosine	SHP1	CHEBI:18186	5777	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Morin inhibits STAT3 tyrosine 705 phosphorylation in tumor cells through activation of protein tyrosine phosphatase SHP1 .
9064328	0	tyrosine	67,75	SHP1	125,129	tyrosine	SHP1	CHEBI:18186	15170(Tax:10090)	Chemical	Gene	c-Kit|compound|START_ENTITY regulation|nmod|c-Kit reveals|dobj|regulation reveals|nmod|END_ENTITY	Genetic analysis reveals cell type-specific regulation of receptor tyrosine kinase c-Kit by the protein tyrosine phosphatase SHP1 .
9162089	0	tyrosine	102,110	SHP1	0,4	tyrosine	SHP1	CHEBI:18186	5777	Chemical	Gene	betac|nmod|START_ENTITY phosphorylation|amod|betac associate|nmod|phosphorylation associate|nsubj|END_ENTITY	SHP1 and SHP2 protein-tyrosine phosphatases associate with betac after interleukin-3-induced receptor tyrosine phosphorylation .
11278704	0	tyrosine	134,142	SHP2	129,133	tyrosine	SHP2	CHEBI:18186	19247(Tax:10090)	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|compound|END_ENTITY	The Gab1 docking protein links the b cell antigen receptor to the phosphatidylinositol_3-kinase / Akt signaling pathway and to the SHP2 tyrosine phosphatase .
11557549	0	tyrosine	23,31	SHP2	44,48	tyrosine	SHP2	CHEBI:18186	25622(Tax:10116)	Chemical	Gene	Requirement|nmod|START_ENTITY phosphatase|nsubj|Requirement phosphatase|dobj|END_ENTITY	Requirement of protein tyrosine phosphatase SHP2 for NO-stimulated vascular smooth muscle cell motility .
14534538	8	tyrosine	1466,1474	SHP2	1391,1395	tyrosine	FRS2	CHEBI:18186	327826(Tax:10090)	Chemical	Gene	START_ENTITY|parataxis|show show|nsubj|protein protein|compound|END_ENTITY	However , the C/S SHP2 protein did not show any effect on receptor autophosphorylation , FRS2 tyrosine phosphorylation or interaction of Grb2 with K/E-FR 3 or FRS2 .
16914719	0	tyrosine	67,75	SHP2	54,58	tyrosine	SHP2	CHEBI:18186	5781	Chemical	Gene	phosphatase|amod|START_ENTITY phosphatase|compound|END_ENTITY	Leukemia-associated , constitutively active mutants of SHP2 protein tyrosine phosphatase inhibit NF1 transcriptional activation by the interferon_consensus_sequence_binding_protein .
18089853	0	tyrosine	40,48	SHP2	27,31	tyrosine	SHP2	CHEBI:18186	5781	Chemical	Gene	phosphatase|amod|START_ENTITY phosphatase|compound|END_ENTITY	Constitutive activation of SHP2 protein tyrosine phosphatase inhibits ICSBP-induced transcription of the gene encoding gp91PHOX during myeloid differentiation .
18832710	0	tyrosine	38,46	SHP2	91,95	tyrosine	SHP2	CHEBI:18186	5781	Chemical	Gene	phosphorylation|compound|START_ENTITY Inhibition|nmod|phosphorylation mediated|nsubjpass|Inhibition mediated|nmod|END_ENTITY	Inhibition of IFN-gamma-induced STAT1 tyrosine phosphorylation by human CMV is mediated by SHP2 .
20170098	0	tyrosine	105,113	SHP2	129,133	tyrosine	SHP2	CHEBI:18186	5781	Chemical	Gene	phosphatase-2|amod|START_ENTITY protein|amod|phosphatase-2 protein|appos|END_ENTITY	Salicylic_acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 -LRB- SHP2 -RRB- .
20682772	0	tyrosine	137,145	SHP2	29,33	tyrosine	SHP2	CHEBI:18186	5781	Chemical	Gene	kinase|compound|START_ENTITY direct|nmod|kinase GDNF|nmod|direct contributes|xcomp|GDNF contributes|nsubj|END_ENTITY	Protein-tyrosine phosphatase SHP2 contributes to GDNF neurotrophic activity through direct binding to phospho-Tyr687 in the RET receptor tyrosine kinase .
21145937	0	tyrosine	105,113	SHP2	85,89	tyrosine	SHP2	CHEBI:18186	5781	Chemical	Gene	phosphatase|compound|START_ENTITY END_ENTITY|nmod|phosphatase	Tyrosine phosphatases as key regulators of StAR induction and cholesterol transport : SHP2 as a potential tyrosine phosphatase involved in steroid synthesis .
21669525	0	tyrosine	34,42	SHP2	29,33	tyrosine	SHP2	CHEBI:18186	5781	Chemical	Gene	phosphatase|amod|START_ENTITY phosphatase|compound|END_ENTITY	Small molecule inhibitors of SHP2 tyrosine phosphatase discovered by virtual screening .
21725048	0	tyrosine	5,13	SHP2	0,4	tyrosine	SHP2	CHEBI:18186	19247(Tax:10090)	Chemical	Gene	phosphatase|amod|START_ENTITY phosphatase|nummod|END_ENTITY	SHP2 tyrosine phosphatase stimulates CEBPA gene expression to mediate cytokine-dependent granulopoiesis .
21726809	0	tyrosine	5,13	SHP2	0,4	tyrosine	SHP2	CHEBI:18186	5781	Chemical	Gene	phosphatase|amod|START_ENTITY phosphatase|nummod|END_ENTITY	SHP2 tyrosine phosphatase converts parafibromin/Cdc73 from a tumor suppressor to an oncogenic driver .
23957426	0	tyrosine	72,80	SHP2	93,97	tyrosine	SHP2	CHEBI:18186	5781	Chemical	Gene	inhibitor|nmod|START_ENTITY cryptotanshinone|nmod|inhibitor Identification|nmod|cryptotanshinone phosphatase|nsubj|Identification phosphatase|dobj|PTPN11 PTPN11|compound|END_ENTITY	Identification of cryptotanshinone as an inhibitor of oncogenic protein tyrosine phosphatase SHP2 -LRB- PTPN11 -RRB- .
24123360	0	tyrosine	103,111	SHP2	90,94	tyrosine	SHP2	CHEBI:18186	5781	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|compound|END_ENTITY	The transition from stem cell to progenitor spermatogonia and male fertility requires the SHP2 protein tyrosine phosphatase .
24618081	0	tyrosine	82,90	SHP2	25,29	tyrosine	SHP2	CHEBI:18186	19247(Tax:10090)	Chemical	Gene	FIP1L1-PDGFRa|amod|START_ENTITY required|nmod|FIP1L1-PDGFRa required|nsubjpass|END_ENTITY	The tyrosine phosphatase SHP2 is required for cell transformation by the receptor tyrosine kinase mutants FIP1L1-PDGFRa and PDGFRa D842V .
24858400	0	tyrosine	23,31	SHP2	18,22	tyrosine	SHP2	CHEBI:18186	5781	Chemical	Gene	phosphatase|amod|START_ENTITY phosphatase|compound|END_ENTITY	Overexpression of SHP2 tyrosine phosphatase promotes the tumorigenesis of breast_carcinoma .
25256404	0	tyrosine	24,32	SHP2	45,49	tyrosine	SHP2	CHEBI:18186	5781	Chemical	Gene	role|nmod|START_ENTITY phosphatase|nsubj|role phosphatase|dobj|END_ENTITY	The role of the protein tyrosine phosphatase SHP2 in cardiac development and disease .
26622699	0	tyrosine	40,48	SHP2	61,65	tyrosine	SHP2	D014443	5781	Chemical	Gene	significance|nmod|START_ENTITY phosphatase|nsubj|significance phosphatase|dobj|END_ENTITY	Expression and clinical significance of tyrosine phosphatase SHP2 in thyroid_carcinoma .
26673822	0	tyrosine	2,10	SHP2	23,27	tyrosine	SHP2	D014443	5781	Chemical	Gene	phosphatase|amod|START_ENTITY mutation|amod|phosphatase mutation|compound|END_ENTITY	A tyrosine phosphatase SHP2 gain-of-function mutation enhances malignancy_of_breast_carcinoma .
9254654	0	tyrosine	23,31	SHP2	83,87	tyrosine	SHP2	CHEBI:18186	5781	Chemical	Gene	phosphatase|compound|START_ENTITY homology|dep|phosphatase homology|parataxis|regulator regulator|nsubj|Src_homology_2_phosphatase_2 Src_homology_2_phosphatase_2|appos|END_ENTITY	Src homology 2 protein tyrosine phosphatase -LRB- SHPTP2 -RRB- / Src_homology_2_phosphatase_2 -LRB- SHP2 -RRB- tyrosine phosphatase is a positive regulator of the interleukin 5 receptor signal transduction pathways leading to the prolongation of eosinophil survival .
9254654	0	tyrosine	89,97	SHP2	83,87	tyrosine	SHP2	CHEBI:18186	5781	Chemical	Gene	phosphatase|amod|START_ENTITY Src_homology_2_phosphatase_2|amod|phosphatase Src_homology_2_phosphatase_2|appos|END_ENTITY	Src homology 2 protein tyrosine phosphatase -LRB- SHPTP2 -RRB- / Src_homology_2_phosphatase_2 -LRB- SHP2 -RRB- tyrosine phosphatase is a positive regulator of the interleukin 5 receptor signal transduction pathways leading to the prolongation of eosinophil survival .
9299490	0	tyrosine	30,38	SHP2	0,4	tyrosine	SHP2	CHEBI:18186	5781	Chemical	Gene	associates|nmod|START_ENTITY associates|nummod|END_ENTITY	SHP2 associates directly with tyrosine phosphorylated p90 -LRB- SNT -RRB- protein in FGF-stimulated cells .
9794795	0	tyrosine	125,133	SHP2	47,51	tyrosine	SHP2	CHEBI:18186	5781	Chemical	Gene	Jak1|amod|START_ENTITY requires|dobj|Jak1 requires|nsubj|Activation Activation|nmod|END_ENTITY	Activation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducing receptor protein gp130 requires tyrosine kinase Jak1 and limits acute-phase protein expression .
9344856	0	tyrosine	39,47	SHPS-1	67,73	tyrosine	SHPS-1	CHEBI:18186	140885	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Epidermal_growth_factor stimulates the tyrosine phosphorylation of SHPS-1 and association of SHPS-1 with SHP-2 , a SH2 domain-containing protein tyrosine phosphatase .
9344856	0	tyrosine	39,47	SHPS-1	93,99	tyrosine	SHPS-1	CHEBI:18186	140885	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Epidermal_growth_factor stimulates the tyrosine phosphorylation of SHPS-1 and association of SHPS-1 with SHP-2 , a SH2 domain-containing protein tyrosine phosphatase .
9582366	0	tyrosine	18,26	SHPS-1	46,52	tyrosine	SHPS-1	CHEBI:18186	140885	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Integrin-mediated tyrosine phosphorylation of SHPS-1 and its association with SHP-2 .
9788431	0	tyrosine	91,99	SHPTP1	76,82	tyrosine	SHPTP1	CHEBI:18186	5777	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|compound|END_ENTITY	Regulation of Bcr-Abl-induced SAP kinase activity and transformation by the SHPTP1 protein tyrosine phosphatase .
9254654	0	tyrosine	23,31	SHPTP2	45,51	tyrosine	SHPTP2	CHEBI:18186	5781	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|appos|END_ENTITY	Src homology 2 protein tyrosine phosphatase -LRB- SHPTP2 -RRB- / Src_homology_2_phosphatase_2 -LRB- SHP2 -RRB- tyrosine phosphatase is a positive regulator of the interleukin 5 receptor signal transduction pathways leading to the prolongation of eosinophil survival .
22468987	0	tyrosine	20,28	SIRPa	48,53	tyrosine	SIRPa	CHEBI:18186	19261(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Hypothermia-induced tyrosine phosphorylation of SIRPa in the brain .
23977047	0	tyrosine	16,24	SIRT1	52,57	tyrosine	SIRT1	D014443	23411	Chemical	Gene	START_ENTITY|dobj|expression expression|nmod|END_ENTITY	Nurr1 represses tyrosine hydroxylase expression via SIRT1 in human neural stem cells .
10397162	0	tyrosine	73,81	SLP-65	48,54	tyrosine	SLP-65	CHEBI:18186	29760	Chemical	Gene	START_ENTITY|nsubj|Characterization Characterization|nmod|END_ENTITY	Characterization of the B cell-specific adaptor SLP-65 and other protein tyrosine kinase substrates by two-dimensional gel electrophoresis .
11449366	0	tyrosine	79,87	SLP-65	15,21	tyrosine	SLP-65	CHEBI:18186	29760	Chemical	Gene	BLNK|nmod|START_ENTITY BLNK|nsubj|Association Association|nmod|/ /|compound|END_ENTITY	Association of SLP-65 / BLNK with the B_cell_antigen_receptor through a non-ITAM tyrosine of Ig-alpha .
12835482	0	tyrosine	9,17	SLP-65	67,73	tyrosine	SLP-65	CHEBI:18186	17060(Tax:10090)	Chemical	Gene	kinase|amod|START_ENTITY cooperates|nsubj|kinase cooperates|nmod|END_ENTITY	Bruton 's tyrosine kinase cooperates with the B cell linker protein SLP-65 as a tumor suppressor in Pre-B cells .
18369315	3	tyrosine	570,578	SLP-65	538,544	tyrosine	SLP-65	CHEBI:18186	29760	Chemical	Gene	mediated|nmod|START_ENTITY mediated|nmod|domain domain|nmod|END_ENTITY	This positive feedback is mediated by the binding of the SH2 domain of SLP-65 to an autophosphorylated tyrosine of Syk .
8703037	0	tyrosine	46,54	SLP-76	90,96	tyrosine	SLP-76	CHEBI:18186	3937	Chemical	Gene	START_ENTITY|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Differential regulation of activation-induced tyrosine phosphorylation and recruitment of SLP-76 to Vav by distinct isoforms of the CD45 protein-tyrosine phosphatase .
12026167	0	tyrosine	97,105	SNT1	55,59	tyrosine	SNT1	CHEBI:18186	10818	Chemical	Gene	START_ENTITY|nsubj|phosphorylation phosphorylation|nmod|END_ENTITY	Cell - and receptor isotype-specific phosphorylation of SNT1 by fibroblast growth factor receptor tyrosine kinases .
17965269	0	tyrosine	25,33	SPO11-1	51,58	tyrosine	SPO11-1	CHEBI:18186	7009000(Tax:10685)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	The catalytically active tyrosine residues of both SPO11-1 and SPO11-2 are required for meiotic double-strand_break induction in Arabidopsis .
12223544	0	tyrosine	150,158	SRC	131,134	tyrosine	SRC	CHEBI:18186	6714	Chemical	Gene	kinases|amod|START_ENTITY kinases|compound|END_ENTITY	Phosphorylation-dependent and phosphorylation-independent modes of modulation of shaker family voltage-gated potassium channels by SRC family protein tyrosine kinases .
12504632	0	tyrosine	22,30	SRC	10,13	tyrosine	SRC	CHEBI:18186	6714	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Activated SRC protein tyrosine kinase is overexpressed in late-stage human ovarian_cancers .
12899629	0	tyrosine	42,50	SRC	30,33	tyrosine	SRC	CHEBI:18186	6714	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|activity activity|nmod|END_ENTITY	Inhibition of the activity of SRC and Abl tyrosine protein kinases by the binding of the Wiskott-Aldrich_syndrome protein .
14504278	0	tyrosine	18,26	SRC	14,17	tyrosine	SRC	CHEBI:18186	6714	Chemical	Gene	START_ENTITY|nsubj|Activation Activation|nmod|END_ENTITY	Activation of SRC tyrosine kinases in response to ICAM-1 ligation in pulmonary microvascular endothelial cells .
15073106	0	tyrosine	18,26	SRC	14,17	tyrosine	SRC	CHEBI:18186	6714	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of SRC tyrosine kinase impairs inherent and acquired gemcitabine resistance in human pancreatic_adenocarcinoma cells .
15585638	0	tyrosine	18,26	SRC	14,17	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of SRC tyrosine kinase as treatment for human pancreatic_cancer growing orthotopically in nude_mice .
16158247	0	tyrosine	4,12	SRC	0,3	tyrosine	SRC	CHEBI:18186	6714	Chemical	Gene	inhibitor|compound|START_ENTITY inhibitor|compound|END_ENTITY	SRC tyrosine kinase inhibitor , m475271 , suppresses subcutaneous growth and production of lung metastasis via inhibition of proliferation , invasion , and vascularization of human lung_adenocarcinoma cells .
16195219	0	tyrosine	18,26	SRC	14,17	tyrosine	SRC	CHEBI:18186	6714	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Inhibition of SRC tyrosine kinases suppresses activation of nuclear factor-kappaB , and serine and tyrosine phosphorylation of IkappaB-alpha in lipopolysaccharide-stimulated raw 264.7 macrophages .
16288028	0	tyrosine	4,12	SRC	0,3	tyrosine	SRC	CHEBI:18186	6714	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	SRC tyrosine kinase and multidrug resistance protein-1 inhibitions act independently but cooperatively to restore paclitaxel sensitivity to paclitaxel-resistant ovarian_cancer cells .
16835269	0	tyrosine	46,54	SRC	18,21	tyrosine	SRC	CHEBI:18186	20779(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY END_ENTITY|nmod|kinase	Identification of SRC as a key PKA-stimulated tyrosine kinase involved in the capacitation-associated hyperactivation of murine spermatozoa .
17400547	0	tyrosine	32,40	SRC	28,31	tyrosine	SRC	CHEBI:18186	20779(Tax:10090)	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Synapsin phosphorylation by SRC tyrosine kinase enhances SRC activity in synaptic vesicles .
18562702	0	tyrosine	38,46	SRC	54,57	tyrosine	SRC	CHEBI:18186	6714	Chemical	Gene	activity|nmod|START_ENTITY kinase|nsubj|activity kinase|dobj|END_ENTITY	Increased activity of the human sperm tyrosine kinase SRC by the cAMP-dependent pathway in the presence of calcium .
20378502	0	tyrosine	26,34	SRC	4,7	tyrosine	SRC	CHEBI:18186	6714	Chemical	Gene	kinases|compound|START_ENTITY family|nmod|kinases family|compound|END_ENTITY	The SRC family of protein tyrosine kinases : a new and promising target for colorectal_cancer therapy .
12083796	0	tyrosine	31,39	SSeCKS	63,69	tyrosine	SSeCKS	CHEBI:18186	83397(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|protein protein|compound|END_ENTITY	Mitogen-induced , FAK-dependent tyrosine phosphorylation of the SSeCKS scaffolding protein .
11587372	0	tyrosine	10,18	ST1571	0,6	tyrosine	ST1571	CHEBI:18186	1459610(Tax:273063)	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|advmod|END_ENTITY	ST1571 , a tyrosine kinase inhibitor for the treatment of chronic_myelogenous_leukemia : validating the promise of molecularly targeted therapy .
12183376	0	tyrosine	77,85	STAT	29,33	tyrosine	STAT	CHEBI:18186	42428(Tax:7227)	Chemical	Gene	START_ENTITY|nsubj|requirement requirement|nmod|END_ENTITY	Differential requirement for STAT by gain-of-function and wild-type receptor tyrosine kinase Torso in Drosophila .
19202101	0	tyrosine	111,119	STAT-1	139,145	tyrosine	STAT-1	CHEBI:18186	6772	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Probiotics prevent enterohaemorrhagic Escherichia_coli O157 : H7-mediated inhibition of interferon-gamma-induced tyrosine phosphorylation of STAT-1 .
19922538	0	tyrosine	106,114	STAT-1	134,140	tyrosine	STAT-1	CHEBI:18186	20846(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	The benzoxathiolone_LYR-71 down-regulates interferon-gamma-inducible pro-inflammatory genes by uncoupling tyrosine phosphorylation of STAT-1 in macrophages .
10029571	0	tyrosine	112,120	STAT1	140,145	tyrosine	STAT1	CHEBI:18186	6772	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Interleukin-10 inhibits expression of both interferon alpha - and interferon_gamma - induced genes by suppressing tyrosine phosphorylation of STAT1 .
18832710	0	tyrosine	38,46	STAT1	32,37	tyrosine	STAT1	CHEBI:18186	6772	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Inhibition of IFN-gamma-induced STAT1 tyrosine phosphorylation by human CMV is mediated by SHP2 .
23178573	0	tyrosine	83,91	STAT1	111,116	tyrosine	STAT1	CHEBI:18186	6772	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	p38 MAP kinase enhances EGF-induced apoptosis in A431 carcinoma cells by promoting tyrosine phosphorylation of STAT1 .
23910645	0	tyrosine	125,133	STAT1	119,124	tyrosine	STAT1	CHEBI:18186	6772	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|compound|END_ENTITY	Protein phosphatase 2A impairs IFNa-induced antiviral activity against the hepatitis_C virus through the inhibition of STAT1 tyrosine phosphorylation .
8651947	0	tyrosine	66,74	STAT1	46,51	tyrosine	STAT1	CHEBI:18186	20846(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|compound|END_ENTITY	Delta-9-tetrahydrocannabinol : an inhibitor of STAT1 alpha protein tyrosine phosphorylation .
8780896	0	tyrosine	19,27	STAT1	13,18	tyrosine	STAT1	CHEBI:18186	6772	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Constitutive STAT1 tyrosine phosphorylation in U937 monocytes overexpressing the TYK2 protein tyrosine kinase does not induce gene transcription .
8805627	0	tyrosine	8,16	STAT1	59,64	tyrosine	STAT1	CHEBI:18186	6772	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Delayed tyrosine phosphorylation and nuclear expression of STAT1 following antigen receptor stimulation of B lymphocytes .
10364193	0	tyrosine	32,40	STAT3	26,31	tyrosine	STAT3	CHEBI:18186	6774	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Oxidative stress triggers STAT3 tyrosine phosphorylation and nuclear translocation in human lymphocytes .
10427504	5	tyrosine	844,852	STAT3	872,877	tyrosine	Cis-1	CHEBI:18186	12700(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	The expression of the SOCS proteins had no effect on CSF-1 mediated STAT3 tyrosine phosphorylation ; however , SOCS-1 and SOCS-3 reduced the tyrosine phosphorylation of STAT3 in response to IL-6 but did not abolish it .
24891320	0	tyrosine	93,101	STAT3	87,92	tyrosine	STAT3	CHEBI:18186	6774	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|compound|END_ENTITY	Transcription of the activating receptor NKG2D in natural killer cells is regulated by STAT3 tyrosine phosphorylation .
9164976	0	tyrosine	30,38	STAT3	58,63	tyrosine	STAT3	CHEBI:18186	6774	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Enhancement of gp130-mediated tyrosine phosphorylation of STAT3 and its DNA-binding activity in dexamethasone-treated AIDS-associated Kaposi 's _ sarcoma cells : selective synergy between dexamethasone and gp130-related growth factors in Kaposi 's _ sarcoma cell proliferation .
7638186	0	tyrosine	23,31	STAT4	66,71	tyrosine	STAT4	CHEBI:18186	6775	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes .
8683106	7	tyrosine	1376,1384	STAT4	1404,1409	tyrosine	STAT3	CHEBI:18186	6774	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	In contrast to IL-2 and IFN-alpha , IL-12 induced strong tyrosine phosphorylation of STAT4 and variable weak phosphorylation of STAT3 .
12384143	0	tyrosine	172,180	STAT5	200,205	tyrosine	STAT5	CHEBI:18186	6776	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Transforming_growth_factor-beta -LRB- 1 -RRB- augments granulocyte-macrophage_colony-stimulating_factor-induced proliferation of umbilical cord blood CD34 -LRB- + -RRB- cells with an associated tyrosine phosphorylation of STAT5 .
15240680	0	tyrosine	60,68	STAT5	88,93	tyrosine	STAT5	CHEBI:18186	20850(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Adenosine acts through A2 receptors to inhibit IL-2-induced tyrosine phosphorylation of STAT5 in T lymphocytes : role of cyclic_adenosine_3 ' ,5 ' - monophosphate and phosphatases .
7544303	0	tyrosine	29,37	STAT5	72,77	tyrosine	STAT5	CHEBI:18186	6776	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Thrombopoietin -LRB- TPO -RRB- induces tyrosine phosphorylation and activation of STAT5 and STAT3 .
9722506	0	tyrosine	92,100	STAT5	120,125	tyrosine	STAT5	CHEBI:18186	6776	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Insulin-like_growth_factor-I augments erythropoietin-induced proliferation through enhanced tyrosine phosphorylation of STAT5 .
10882748	0	tyrosine	29,37	STAT6	57,62	tyrosine	STAT6	CHEBI:18186	20852(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Interleukin-15 induces rapid tyrosine phosphorylation of STAT6 and the expression of interleukin-4 in mouse mast cells .
7579443	0	tyrosine	117,125	STK	105,108	tyrosine	STK	CHEBI:18186	19882(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Terminal differentiation of murine resident peritoneal macrophages is characterized by expression of the STK protein tyrosine kinase , a receptor for macrophage-stimulating_protein .
8611695	0	tyrosine	54,62	STK	41,44	tyrosine	STK	CHEBI:18186	19882(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Macrophage-stimulating_protein activates STK receptor tyrosine kinase on osteoclasts and facilitates bone resorption by osteoclast-like cells .
8611695	1	tyrosine	179,187	STK	196,199	tyrosine	STK	CHEBI:18186	19882(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	Recently we cloned a novel receptor tyrosine kinase , STK .
18938080	0	tyrosine	95,103	SYK	112,115	tyrosine	SYK	CHEBI:18186	6850	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase -LRB- SYK -RRB- .
20133729	0	tyrosine	28,36	SYK	24,27	tyrosine	SYK	CHEBI:18186	6850	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	STAT3 is a substrate of SYK tyrosine kinase in B-lineage leukemia/lymphoma cells exposed to oxidative_stress .
20467426	0	tyrosine	8,16	SYK	4,7	tyrosine	SYK	CHEBI:18186	44353(Tax:7227)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The SYK tyrosine kinase : a crucial player in diverse biological functions .
23220742	1	tyrosine	240,248	SYK	257,260	tyrosine	SYK	CHEBI:18186	20963(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	B-cell receptor -LRB- BCR -RRB- associated kinases including spleen tyrosine kinase -LRB- SYK -RRB- contribute to the pathogenesis of B-cell malignancies .
23704133	0	tyrosine	93,101	SYK	110,113	tyrosine	SYK	CHEBI:18186	6850	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	Development of a pharmacodynamic assay based on PLCy2 phosphorylation for quantifying spleen tyrosine kinase -LRB- SYK -RRB- - Bruton 's _ tyrosine_kinase -LRB- BTK -RRB- signaling .
10358169	0	tyrosine	66,74	Sam68	94,99	tyrosine	Sam68	CHEBI:18186	10657	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Fyn membrane localization is necessary to induce the constitutive tyrosine phosphorylation of Sam68 in the nucleus of T lymphocytes .
8930398	0	tyrosine	19,27	Sam68	73,78	tyrosine	Sam68	CHEBI:18186	20218(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Radicicol inhibits tyrosine phosphorylation of the mitotic Src substrate Sam68 and retards subsequent exit from mitosis of Src-transformed cells .
9045636	0	tyrosine	41,49	Sam68	20,25	tyrosine	Sam68	CHEBI:18186	10657	Chemical	Gene	START_ENTITY|nsubj|Interaction Interaction|nmod|END_ENTITY	Interaction between Sam68 and Src family tyrosine kinases , Fyn and Lck , in T_cell_receptor signaling .
9464824	0	tyrosine	92,100	Sam68	120,125	tyrosine	Sam68	CHEBI:18186	10657	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	A dual participation of ZAP-70 and scr protein tyrosine kinases is required for TCR-induced tyrosine phosphorylation of Sam68 in Jurkat T cells .
7522971	0	tyrosine	102,110	Sek	89,92	tyrosine	Sek	CHEBI:18186	13838(Tax:10090)	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Identification and cloning of ELF-1 , a developmentally expressed ligand for the Mek4 and Sek receptor tyrosine kinases .
10878015	1	tyrosine	168,176	Shb	164,167	tyrosine	Shb	CHEBI:18186	362513(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY END_ENTITY|dobj|phosphorylation	Relationship to Shb tyrosine phosphorylation and elevated levels of focal_adhesion_kinase .
11884620	0	tyrosine	76,84	Shc	72,75	tyrosine	Shc	CHEBI:18186	6464	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Protein phosphatase 2A forms a molecular complex with Shc and regulates Shc tyrosine phosphorylation and downstream mitogenic signaling .
11884620	8	tyrosine	1300,1308	Shc	1296,1299	tyrosine	Shc	CHEBI:18186	6464	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Furthermore , Shc tyrosine phosphorylation and its association with Grb2 were also elevated in small-t-antigen-expressing cells .
11897789	0	tyrosine	65,73	Shc	93,96	tyrosine	Shc	CHEBI:18186	6464	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Phosphatidylinositol 3-kinase is required for insulin-stimulated tyrosine phosphorylation of Shc in 3T3-L1 adipocytes .
12589038	0	tyrosine	18,26	Shc	46,49	tyrosine	Shc	CHEBI:18186	6464	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Integrin-mediated tyrosine phosphorylation of Shc in T cells is regulated by protein kinase C-dependent phosphorylations of Lck .
12789267	0	tyrosine	29,37	Shc	14,17	tyrosine	Shc	CHEBI:18186	20416(Tax:10090)	Chemical	Gene	binding|xcomp|START_ENTITY binding|nsubj|END_ENTITY	v-Src induces Shc binding to tyrosine 63 in the cytoplasmic domain of the LDL_receptor-related_protein_1 .
7488124	0	tyrosine	96,104	Shc	124,127	tyrosine	Shc	CHEBI:18186	6464	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|proteins proteins|compound|END_ENTITY	The liver response to in vivo heat_shock involves the activation of MAP kinases and RAF and the tyrosine phosphorylation of Shc proteins .
7537361	2	tyrosine	202,210	Shc	230,233	tyrosine	Shc	CHEBI:18186	6464	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	P210 BCR/abl tyrosine kinase induces tyrosine phosphorylation of Shc , and activation of p21ras and PI 3-Kinase .
7691810	0	tyrosine	30,38	Shc	58,61	tyrosine	Shc	CHEBI:18186	6464	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Multiple cytokines induce the tyrosine phosphorylation of Shc and its association with Grb2 in hemopoietic cells .
7929159	0	tyrosine	19,27	Shc	68,71	tyrosine	Shc	CHEBI:18186	6464	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Endothelin induces tyrosine phosphorylation and GRB2 association of Shc in astrocytes .
8088325	0	tyrosine	134,142	Shc	162,165	tyrosine	Shc	CHEBI:18186	20416(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Gene transfer of the interleukin -LRB- IL -RRB- -2 receptor beta chain into an IL-7-dependent pre-B cell line permits IL-2-driven proliferation : tyrosine phosphorylation of Shc is induced by IL-2 but not IL-7 .
8144900	0	tyrosine	19,27	Shc	47,50	tyrosine	Shc	CHEBI:18186	6464	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Correlations among tyrosine phosphorylation of Shc , p72syk , PLC-gamma_1 , and -LSB- Ca2 + -RSB- i flux in Fc_gamma_RIIA signaling .
8400282	0	tyrosine	30,38	Shc	58,61	tyrosine	Shc	CHEBI:18186	20416(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Erythropoietin stimulates the tyrosine phosphorylation of Shc and its association with Grb2 and a 145-Kd tyrosine phosphorylated protein .
8549807	0	tyrosine	16,24	Shc	44,47	tyrosine	Shc	CHEBI:18186	6464	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|proteins proteins|compound|END_ENTITY	Gastrin induces tyrosine phosphorylation of Shc proteins and their association with the Grb2/Sos complex .
8617307	0	tyrosine	22,30	Shc	77,80	tyrosine	Shc	CHEBI:18186	6464	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Interleukin-6 induces tyrosine phosphorylation of the Ras activating protein Shc , and its complex formation with Grb2 in the human multiple myeloma cell line LP-1 .
9009167	0	tyrosine	14,22	Shc	42,45	tyrosine	Shc	CHEBI:18186	20416(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Taxol induces tyrosine phosphorylation of Shc and its association with Grb2 in murine RAW 264.7 cells .
9013573	0	tyrosine	20,28	Shc	48,51	tyrosine	Shc	CHEBI:18186	6464	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Cripto enhances the tyrosine phosphorylation of Shc and activates mitogen-activated protein kinase -LRB- MAPK -RRB- in mammary epithelial cells .
9096689	0	tyrosine	34,42	Shc	62,65	tyrosine	Shc	CHEBI:18186	6464	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Antisense src expression inhibits tyrosine phosphorylation of Shc and its association with Grb2 and Sos which leads to MAP kinase activation in U937 human leukemia cells .
9677414	0	tyrosine	39,47	Shc	35,38	tyrosine	Shc	CHEBI:18186	6464	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	The calcitonin_receptor stimulates Shc tyrosine phosphorylation and Erk1/2 activation .
9710204	7	tyrosine	1051,1059	Shc	1079,1082	tyrosine	syk	CHEBI:18186	6850	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	In T cells , CD4/Lck-dependent tyrosine phosphorylation on Shc was markedly diminished when Y317 was mutated , suggesting a preference of Lck for the Y317 site .
9813159	0	tyrosine	28,36	Shc	24,27	tyrosine	Shc	CHEBI:18186	6464	Chemical	Gene	START_ENTITY|nsubj|involvement involvement|nmod|END_ENTITY	Relative involvement of Shc tyrosine 239/240 and tyrosine 317 on insulin induced mitogenic signaling in rat1 fibroblasts expressing insulin receptors .
11707405	0	tyrosine	5,13	ShcA	0,4	tyrosine	ShcA	CHEBI:18186	20416(Tax:10090)	Chemical	Gene	sites|compound|START_ENTITY sites|compound|END_ENTITY	ShcA tyrosine phosphorylation sites can replace ShcA binding in signalling by middle T-antigen .
15115663	0	tyrosine	21,29	Shp-1	4,9	tyrosine	Shp-1	CHEBI:18186	116689(Tax:10116)	Chemical	Gene	phosphatases|amod|START_ENTITY END_ENTITY|appos|phosphatases	The Shp-1 and Shp-2 , tyrosine phosphatases , are recruited on cell membrane in two distinct molecular complexes including Ret oncogenes .
10579910	0	tyrosine	6,14	Shp-2	0,5	tyrosine	Shp-2	CHEBI:18186	45278(Tax:7227)	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|amod|END_ENTITY	Shp-2 tyrosine phosphatase : signaling one cell or many .
10669730	0	tyrosine	34,42	Shp-2	28,33	tyrosine	Shp-2	CHEBI:18186	19247(Tax:10090)	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|compound|END_ENTITY	Molecular mechanism for the Shp-2 tyrosine phosphatase function in promoting growth factor stimulation of Erk activity .
16765027	0	tyrosine	6,14	Shp-2	0,5	tyrosine	Shp-2	CHEBI:18186	5781	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|amod|END_ENTITY	Shp-2 tyrosine phosphatase is required for hepatocyte_growth_factor-induced activation of sphingosine kinase and migration_in_embryonic_fibroblasts .
19497338	0	tyrosine	49,57	Shp1	71,75	tyrosine	Shp1	CHEBI:18186	5777	Chemical	Gene	114|amod|START_ENTITY prohibitin|nmod|114 phosphorylation|nmod|prohibitin recruits|nsubj|phosphorylation recruits|dobj|END_ENTITY	Insulin induced phosphorylation of prohibitin at tyrosine 114 recruits Shp1 .
22539788	0	tyrosine	48,56	Shp1	69,73	tyrosine	Shp1	CHEBI:18186	15170(Tax:10090)	Chemical	Gene	START_ENTITY|ccomp|promotes promotes|nsubj|END_ENTITY	Dendritic cell-specific ablation of the protein tyrosine phosphatase Shp1 promotes Th1 cell differentiation and induces autoimmunity .
8673130	0	tyrosine	33,41	Shp1	117,121	tyrosine	Shp1	CHEBI:18186	15170(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY Signalling|nmod|kinase regulated|csubjpass|Signalling regulated|nmod|END_ENTITY	Signalling by the W/Kit receptor tyrosine kinase is negatively regulated in vivo by the protein tyrosine phosphatase Shp1 .
15520383	0	tyrosine	14,22	Shp2	9,13	tyrosine	Shp2	CHEBI:18186	19247(Tax:10090)	Chemical	Gene	phosphatase|amod|START_ENTITY END_ENTITY|amod|phosphatase	Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism .
16030196	0	tyrosine	23,31	Shp2	18,22	tyrosine	Shp2	CHEBI:18186	5781	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|amod|END_ENTITY	Overexpression of Shp2 tyrosine phosphatase is implicated in leukemogenesis in adult human leukemia .
17056523	0	tyrosine	29,37	Shp2	24,28	tyrosine	Shp2	CHEBI:18186	5781	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|amod|END_ENTITY	Conditional deletion of Shp2 tyrosine phosphatase in thymocytes suppresses both pre-TCR and TCR signals .
17483340	0	tyrosine	4,12	Shp2	25,29	tyrosine	Shp2	CHEBI:18186	5781	Chemical	Gene	phosphatase|nsubj|START_ENTITY phosphatase|dobj|interacts interacts|amod|END_ENTITY	The tyrosine phosphatase Shp2 interacts with NPM-ALK and regulates anaplastic_lymphoma cell growth and migration .
18286234	0	tyrosine	4,12	Shp2	25,29	tyrosine	Shp2	CHEBI:18186	5781	Chemical	Gene	phosphatase|amod|START_ENTITY END_ENTITY|amod|phosphatase	The tyrosine phosphatase Shp2 -LRB- PTPN11 -RRB- in cancer .
18680359	0	tyrosine	55,63	Shp2	79,83	tyrosine	Shp2	CHEBI:18186	5781	Chemical	Gene	phosphatase-2|amod|START_ENTITY protein|amod|phosphatase-2 protein|appos|END_ENTITY	Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 -LRB- Shp2 -RRB- based on oxindole scaffolds .
19001090	0	tyrosine	17,25	Shp2	12,16	tyrosine	Shp2	CHEBI:18186	19247(Tax:10090)	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|amod|END_ENTITY	Deletion of Shp2 tyrosine phosphatase in muscle leads to dilated_cardiomyopathy , insulin resistance , and premature_death .
19380737	0	tyrosine	31,39	Shp2	26,30	tyrosine	Shp2	CHEBI:18186	25622(Tax:10116)	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|amod|END_ENTITY	Coordinated regulation by Shp2 tyrosine phosphatase of signaling events controlling insulin biosynthesis in pancreatic beta-cells .
20399956	0	tyrosine	4,12	Shp2	25,29	tyrosine	Shp2	CHEBI:18186	5781	Chemical	Gene	phosphatase|nsubj|START_ENTITY phosphatase|dobj|END_ENTITY	The tyrosine phosphatase Shp2 in development and cancer .
21193311	0	tyrosine	13,21	Shp2	0,4	tyrosine	Shp2	CHEBI:18186	5781	Chemical	Gene	START_ENTITY|nsubj|protein protein|amod|END_ENTITY	Shp2 protein tyrosine phosphatase inhibitor activity of estramustine_phosphate and its triterpenoid analogs .
21930766	0	tyrosine	71,79	Shp2	100,104	tyrosine	Shp2	CHEBI:18186	19247(Tax:10090)	Chemical	Gene	Ptpn11|amod|START_ENTITY mutation|nmod|Ptpn11 effects|nmod|mutation effects|appos|END_ENTITY	Non-lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 -LRB- Shp2 -RRB- on malignant transformation of hematopoietic cells .
23103841	0	tyrosine	12,20	Shp2	34,38	tyrosine	Shp2	CHEBI:18186	5781	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|appos|END_ENTITY	The protein tyrosine phosphatase , Shp2 , positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant_disease in vivo .
23318428	0	tyrosine	30,38	Shp2	58,62	tyrosine	Shp2	CHEBI:18186	333979(Tax:7955)	Chemical	Gene	START_ENTITY|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Involvement of EphA2-mediated tyrosine phosphorylation of Shp2 in Shp2-regulated activation of extracellular signal-regulated kinase .
23675459	0	tyrosine	32,40	Shp2	61,65	tyrosine	Shp2	CHEBI:18186	5781	Chemical	Gene	START_ENTITY|ccomp|enhance enhance|nsubj|Ptpn11 Ptpn11|appos|END_ENTITY	Activating mutations in protein tyrosine phosphatase Ptpn11 -LRB- Shp2 -RRB- enhance reactive oxygen species production that contributes to myeloproliferative_disorder .
23884424	0	tyrosine	63,71	Shp2	92,96	tyrosine	Shp2	CHEBI:18186	19247(Tax:10090)	Chemical	Gene	Ptpn11|compound|START_ENTITY mutation|nmod|Ptpn11 Induction|nmod|mutation Induction|appos|END_ENTITY	Induction of a tumor-associated activating mutation in protein tyrosine phosphatase Ptpn11 -LRB- Shp2 -RRB- enhances mitochondrial metabolism , leading to oxidative stress and senescence .
24216759	0	tyrosine	115,123	Shp2	110,114	tyrosine	Shp2	CHEBI:18186	5781	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|amod|END_ENTITY	Receptor tyrosine kinase ubiquitylation involves the dynamic regulation of Cbl-Spry2 by intersectin_1 and the Shp2 tyrosine phosphatase .
24599474	0	tyrosine	12,20	Shp2	33,37	tyrosine	Shp2	CHEBI:18186	19247(Tax:10090)	Chemical	Gene	START_ENTITY|ccomp|required required|nsubjpass|END_ENTITY	The protein tyrosine phosphatase Shp2 is required for the generation of oligodendrocyte progenitor cells and myelination in the mouse telencephalon .
26644409	0	tyrosine	42,50	Shp2	0,4	tyrosine	Shp2	D014443	19247(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY enhances|dobj|phosphorylation enhances|nsubj|associates associates|amod|END_ENTITY	Shp2 associates with and enhances nephrin tyrosine phosphorylation and is necessary for foot process spreading in mouse models of podocyte injury .
9632781	0	tyrosine	16,24	Shp2	11,15	tyrosine	Shp2	CHEBI:18186	25622(Tax:10116)	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|amod|END_ENTITY	Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation .
9405638	0	tyrosine	40,48	Sik	56,59	tyrosine	Sik	CHEBI:18186	20459(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY kinase|nsubj|role kinase|dobj|END_ENTITY	A role for the epithelial-cell-specific tyrosine kinase Sik during keratinocyte differentiation .
15039778	0	tyrosine	14,22	Sos-1	42,47	tyrosine	Sos-1	CHEBI:18186	6654	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Abl-dependent tyrosine phosphorylation of Sos-1 mediates growth-factor-induced Rac activation .
12646235	0	tyrosine	56,64	Spred-3	31,38	tyrosine	Spred-3	CHEBI:18186	399473	Chemical	Gene	START_ENTITY|nsubj|cloning cloning|nmod|END_ENTITY	Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation .
17352739	4	tyrosine	823,831	Sprouty2	851,859	tyrosine	Sprouty2	CHEBI:18186	10253	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	This down-regulation of Necl-5 caused tyrosine phosphorylation of Sprouty2 by c-Src , which was activated by PDGF receptor in response to PDGF , and inhibited PDGF-induced Ras signaling .
10208413	0	tyrosine	49,57	Src	45,48	tyrosine	Src	CHEBI:18186	20779(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The Shp-2 tyrosine phosphatase activates the Src tyrosine kinase by a non-enzymatic mechanism .
10358079	0	tyrosine	82,90	Src	78,81	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases .
10380880	0	tyrosine	94,102	Src	90,93	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	STAT activation by the PDGF receptor requires juxtamembrane phosphorylation sites but not Src tyrosine kinase activation .
10473101	0	tyrosine	14,22	Src	10,13	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Decreased Src tyrosine kinase activity inhibits malignant_human_ovarian_cancer_tumor growth in a nude mouse model .
10567420	0	tyrosine	91,99	Src	87,90	tyrosine	Src	CHEBI:18186	20779(Tax:10090)	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Agonist-dependent phosphorylation of the G_protein-coupled_receptor_kinase_2 -LRB- GRK2 -RRB- by Src tyrosine kinase .
10591626	0	tyrosine	4,12	Src	0,3	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Src tyrosine kinase activity down-regulates Rho-dependent responses during Shigella entry into epithelial cells and stress fibre formation .
10884308	0	tyrosine	36,44	Src	32,35	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|compound|END_ENTITY	Modulation of Kv1 .5 currents by Src tyrosine phosphorylation : potential role in the differentiation of astrocytes .
11007482	0	tyrosine	4,12	Src	0,3	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Src tyrosine kinase is a novel direct effector of G proteins .
11244024	0	tyrosine	4,12	Src	0,3	tyrosine	Src	CHEBI:18186	83805(Tax:10116)	Chemical	Gene	kinases|amod|START_ENTITY END_ENTITY|dobj|kinases	Src tyrosine kinases and extracellular_signal-regulated_kinase 1/2 mitogen-activated protein kinases mediate pressure-induced c-fos expression in cannulated rat mesenteric small arteries .
11263990	0	tyrosine	56,64	Src	52,55	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Hsp27-induced MMP-9 expression is influenced by the Src tyrosine protein kinase yes .
11274196	0	tyrosine	66,74	Src	55,58	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Soluble E-selectin induces monocyte chemotaxis through Src family tyrosine kinases .
11369518	1	tyrosine	159,167	Src	155,158	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	kinase|amod|START_ENTITY kinase|amod|END_ENTITY	Role of Grb2 , phosphatidylinositol 3-kinase , Src tyrosine kinase , and phospholipase Cgamma .
11514272	0	tyrosine	4,12	Src	0,3	tyrosine	Src	CHEBI:18186	83805(Tax:10116)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Src tyrosine kinase is the trigger but not the mediator of ischemic preconditioning .
11583988	0	tyrosine	152,160	Src	141,144	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Voltage-independent inhibition of P/Q-type Ca2 + channels in adrenal chromaffin cells via a neuronal Ca2 + sensor-1-dependent pathway involves Src family tyrosine kinase .
11875716	0	tyrosine	4,12	Src	0,3	tyrosine	Src	CHEBI:18186	20779(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Src tyrosine kinase augments taxotere-induced apoptosis through enhanced expression and phosphorylation of Bcl-2 .
11964124	0	tyrosine	37,45	Src	33,36	tyrosine	Src	CHEBI:18186	20779(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|END_ENTITY	Novel regulation and function of Src tyrosine kinase .
12014986	0	tyrosine	145,153	Src	141,144	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Phospholipase_D1 is threonine-phosphorylated in human-airway epithelial cells stimulated by sphingosine-1-phosphate by a mechanism involving Src tyrosine kinase and protein kinase Cdelta .
12235291	0	tyrosine	11,19	Src	0,3	tyrosine	Src	CHEBI:18186	20779(Tax:10090)	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Src family tyrosine kinases regulate adhesion-dependent tyrosine phosphorylation of 5 ' - inositol phosphatase SHIP2 during cell attachment and spreading on collagen I. Inositol phosphatases play an important role in regulation of cellular levels of lipid second messengers .
12433841	0	tyrosine	34,42	Src	15,18	tyrosine	Src	CHEBI:18186	83805(Tax:10116)	Chemical	Gene	kinases|amod|START_ENTITY kinases|compound|END_ENTITY	Involvement of Src family protein tyrosine kinases in Ca -LRB- 2 + -RRB- sensitization of coronary artery contraction mediated by a sphingosylphosphorylcholine-Rho-kinase pathway .
12522105	1	tyrosine	83,91	Src	79,82	tyrosine	Src	CHEBI:18186	20779(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of Src tyrosine kinase .
12633868	0	tyrosine	34,42	Src	30,33	tyrosine	Src	CHEBI:18186	83805(Tax:10116)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Lithium-induced inhibition of Src tyrosine kinase in rat cerebral cortical neurons : a role in neuroprotection against N-methyl-D-aspartate receptor-mediated excitotoxicity .
12695509	0	tyrosine	77,85	Src	73,76	tyrosine	Src	CHEBI:18186	83805(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	H-Ras modulates N-methyl-D-aspartate receptor function via inhibition of Src tyrosine kinase activity .
12790800	0	tyrosine	18,26	Src	14,17	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Inhibition of Src tyrosine kinase stimulates adrenal androgen production .
12842760	0	tyrosine	37,45	Src	33,36	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Involvement of G -LRB- i -RRB- proteins and Src tyrosine kinase in TNFalpha production induced by lipopolysaccharide , group B Streptococci and Staphylococcus_aureus .
12924714	0	tyrosine	20,28	Src	16,19	tyrosine	Src	CHEBI:18186	485864(Tax:9615)	Chemical	Gene	START_ENTITY|nsubj|Contribution Contribution|nmod|END_ENTITY	Contribution of Src tyrosine kinase to cerebral_vasospasm after subarachnoid_hemorrhage .
12941335	0	tyrosine	68,76	Src	64,67	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Bone-targeted 2,6,9-trisubstituted _ purines : novel inhibitors of Src tyrosine kinase for the treatment of bone_diseases .
12941336	0	tyrosine	70,78	Src	66,69	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Bone-targeted pyrido -LSB- 2,3-d -RSB- pyrimidin-7-ones : potent inhibitors of Src tyrosine kinase as novel antiresorptive agents .
12951060	0	tyrosine	4,12	Src	0,3	tyrosine	Src	CHEBI:18186	20779(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Src tyrosine kinase promotes survival and resistance to chemotherapeutics in a mouse ovarian_cancer cell line .
14506284	0	tyrosine	77,85	Src	73,76	tyrosine	Src	CHEBI:18186	20779(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Epidermal_growth_factor-dependent regulation of Cdc42 is mediated by the Src tyrosine kinase .
14529711	1	tyrosine	124,132	Src	89,92	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	kinases|compound|START_ENTITY family|nmod|kinases family|compound|END_ENTITY	Five members of the Src family of non-receptor protein tyrosine kinases -- Lck , Lyn , Fyn , Src , and Yes -- are known to be expressed in the central nervous system .
14990578	0	tyrosine	23,31	Src	19,22	tyrosine	Src	CHEBI:18186	20779(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|roles roles|nmod|END_ENTITY	Distinct roles for Src tyrosine kinase in beta2-adrenergic receptor signaling to MAPK and in receptor internalization .
14993658	0	tyrosine	73,81	Src	59,62	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	kinases|amod|START_ENTITY family|nmod|kinases family|compound|END_ENTITY	The hepatitis_C_virus NS5A protein binds to members of the Src family of tyrosine kinases and regulates kinase activity .
15039213	0	tyrosine	44,52	Src	87,90	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	receptor|amod|START_ENTITY receptor|nmod|END_ENTITY	Expression of a truncated form of the c-Kit tyrosine kinase receptor and activation of Src kinase in human prostatic_cancer .
15069201	1	tyrosine	148,156	Src	118,121	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	kinase|compound|START_ENTITY kinase|nsubj|END_ENTITY	Src is the prototypic protein tyrosine kinase and is critical for controlling diverse cellular functions .
15300219	0	tyrosine	30,38	Src	16,19	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	family|nmod|START_ENTITY family|compound|END_ENTITY	The role of the Src family of tyrosine kinases after oxidant-induced lung_injury in vivo .
15304482	0	tyrosine	79,87	Src	75,78	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Dual phosphorylations underlie modulation of unitary KCNQ K -LRB- + -RRB- channels by Src tyrosine kinase .
15337529	0	tyrosine	4,12	Src	0,3	tyrosine	Src	CHEBI:18186	83805(Tax:10116)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Src tyrosine kinase regulates insulin-induced activation of protein kinase C -LRB- PKC -RRB- delta in skeletal muscle .
15477664	0	tyrosine	42,50	Src	23,26	tyrosine	Src	CHEBI:18186	20779(Tax:10090)	Chemical	Gene	kinases|amod|START_ENTITY kinases|compound|END_ENTITY	Rethinking the role of Src family protein tyrosine kinases in the allergic response : new insights on the functional coupling of the high affinity IgE receptor .
15564576	0	tyrosine	115,123	Src	104,107	tyrosine	Src	CHEBI:18186	83805(Tax:10116)	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Lateral hypothalamic signaling mechanisms underlying feeding stimulation : differential contributions of Src family tyrosine kinases to feeding triggered either by NMDA injection or by food deprivation .
15577202	0	tyrosine	73,81	Src	62,65	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Casein kinase 2 -LRB- CK2 -RRB- - mediated reduction of the activities of Src family tyrosine kinases in vitro .
15681694	0	tyrosine	102,110	Src	81,84	tyrosine	Src	CHEBI:18186	100341599(Tax:9986)	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Antagonistic regulation of swelling-activated Cl - current in rabbit ventricle by Src and EGFR protein tyrosine kinases .
15711029	0	tyrosine	4,12	Src	0,3	tyrosine	Src	CHEBI:18186	20779(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Src tyrosine kinase regulates CYP17 expression and androstenedione secretion in theca-enriched mouse ovarian cells .
15781338	0	tyrosine	11,19	Src	0,3	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Src family tyrosine kinases are activated by Flt3 and are involved in the proliferative effects of leukemia-associated Flt3 mutations .
15831816	0	tyrosine	69,77	Src	58,61	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Modulation of the cardiac sodium channel NaV1 .5 by Fyn , a Src family tyrosine kinase .
15854740	0	tyrosine	18,26	Src	14,17	tyrosine	Src	CHEBI:18186	83805(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Activation Activation|nmod|END_ENTITY	Activation of Src tyrosine kinase in microglia in the rat hippocampus following transient forebrain_ischemia .
16123104	0	tyrosine	19,27	Src	15,18	tyrosine	Src	CHEBI:18186	83805(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of Src tyrosine kinase and mitogen-activated protein kinase in the facilitation of calcium channels in rat nucleus of the tractus solitarius by angiotensin_II .
16428929	0	tyrosine	4,12	Src	0,3	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	kinase|amod|START_ENTITY END_ENTITY|dobj|kinase	Src tyrosine kinase as a chemotherapeutic target : is there a clinical case ?
16440311	0	tyrosine	113,121	Src	109,112	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Collagen type I selectively activates ectodomain shedding of the discoidin_domain_receptor_1 : involvement of Src tyrosine kinase .
16492148	0	tyrosine	24,32	Src	20,23	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	START_ENTITY|nsubj|basis basis|nmod|END_ENTITY	Structural basis of Src tyrosine kinase inhibition with a new class of potent and selective trisubstituted purine-based compounds .
16532343	8	tyrosine	1763,1771	Src	1759,1762	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	Treatment of v-src-transfected cells with herbimycin_A , a Src tyrosine kinase inhibitor , partially reversed the gefitinib resistance , with concomitant inhibition of Akt and Erk .
16567399	0	tyrosine	28,36	Src	24,27	tyrosine	Src	CHEBI:18186	380430(Tax:8355)	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Phylogeny of vertebrate Src tyrosine kinases revealed by the epitope region of mAb327 .
16828070	0	tyrosine	109,117	Src	105,108	tyrosine	Src	CHEBI:18186	20779(Tax:10090)	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Calcineurin regulates NFAT-dependent iNOS expression and protection of cardiomyocytes : co-operation with Src tyrosine kinase .
17075193	0	tyrosine	13,21	Src	1,4	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	START_ENTITY|nsubj|protein protein|compound|END_ENTITY	-LSB- Src protein tyrosine kinase family and acute_lung_injury -RSB- .
17312130	0	tyrosine	27,35	Src	15,18	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	START_ENTITY|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of Src and Syk tyrosine kinases in HIV-1 transfer from dendritic cells to CD4 + T lymphocytes .
17401665	0	tyrosine	40,48	Src	36,39	tyrosine	Src	CHEBI:18186	83805(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Effect of radicicol infusion on the Src tyrosine kinase activity of rat hippocampus before and after training in an inhibitory avoidance task .
17432722	0	tyrosine	18,26	Src	14,17	tyrosine	Src	CHEBI:18186	83805(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of Src tyrosine kinase and effect on outcomes in a new in vivo model of surgically induced brain_injury .
17493752	0	tyrosine	53,61	Src	49,52	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Japanese_encephalitis_virus infection stimulates Src tyrosine kinase in neuron/glia .
17522142	0	tyrosine	76,84	Src	72,75	tyrosine	Src	CHEBI:18186	100341599(Tax:9986)	Chemical	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Purinergic agonists stimulate lens Na-K-ATPase-mediated transport via a Src tyrosine kinase-dependent pathway .
17785844	0	tyrosine	71,79	Src	17,20	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	ICAM-1-mediated , Src - and Pyk2-dependent vascular_endothelial_cadherin tyrosine phosphorylation is required for leukocyte transendothelial migration .
17803936	0	tyrosine	55,63	Src	71,74	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	kinase|amod|START_ENTITY END_ENTITY|amod|kinase	The tumor suppressor DAPK is reciprocally regulated by tyrosine kinase Src and phosphatase LAR .
18516760	0	tyrosine	19,27	Src	15,18	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Development of Src tyrosine kinase substrate binding site inhibitors .
18584337	0	tyrosine	19,27	Src	15,18	tyrosine	Src	CHEBI:18186	83805(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of Src tyrosine kinases -LRB- SFKs -RRB- and of focal_adhesion_kinase -LRB- FAK -RRB- in the injurious mechanism in rat primary neuronal cultures exposed to chemical ischemia .
18615581	0	tyrosine	42,50	Src	38,41	tyrosine	Src	CHEBI:18186	20779(Tax:10090)	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Low-power laser irradiation activates Src tyrosine kinase through reactive oxygen species-mediated signaling pathway .
18642057	0	tyrosine	8,16	Src	4,7	tyrosine	Src	CHEBI:18186	20779(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The Src tyrosine kinase pathway regulates thecal CYP17 expression and androstenedione secretion .
18794807	0	tyrosine	18,26	Src	14,17	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Inhibition of Src tyrosine kinase reverts chemoresistance toward 5-fluorouracil in human pancreatic_carcinoma cells : an involvement of epidermal_growth_factor_receptor signaling .
19095999	0	tyrosine	12,20	Src	8,11	tyrosine	Src	CHEBI:18186	20779(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of Src tyrosine kinase in the atherogenic effects of the 12/15-lipoxygenase pathway in vascular smooth muscle cells .
19244618	0	tyrosine	150,158	Src	130,133	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Identification of N-terminal lobe motifs that determine the kinase activity of the catalytic domains and regulatory strategies of Src and Csk protein tyrosine kinases .
19446022	0	tyrosine	42,50	Src	38,41	tyrosine	Src	CHEBI:18186	20779(Tax:10090)	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Brain-specific Galphaz interacts with Src tyrosine kinase to regulate Mu-opioid receptor-NMDAR signaling pathway .
19470583	0	tyrosine	110,118	Src	106,109	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Integrin alpha9beta1 mediates enhanced cell migration through nitric_oxide synthase activity regulated by Src tyrosine kinase .
19755386	0	tyrosine	4,12	Src	0,3	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Src tyrosine kinase regulates adhesion and chemotaxis in Waldenstrom_macroglobulinemia .
20176329	0	tyrosine	39,47	Src	22,25	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	-LSB- Neuronal isoforms of Src , Fyn and Lck tyrosine kinases : A specific role for p56lckN in neuron protection -RSB- .
20307614	0	tyrosine	4,12	Src	0,3	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Src tyrosine kinase regulates angiotensin_II-induced protein_kinase_Czeta activation and proliferation in vascular smooth muscle cells .
20416357	0	tyrosine	26,34	Src	14,17	tyrosine	Src	CHEBI:18186	20779(Tax:10090)	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Activation of Src protein tyrosine kinase plays an essential role in urocortin-mediated cardioprotection .
20551327	0	tyrosine	147,155	Src	216,219	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Proteolysis-induced N-terminal ectodomain shedding of the integral membrane glycoprotein CUB domain-containing protein 1 -LRB- CDCP1 -RRB- is accompanied by tyrosine phosphorylation of its C-terminal domain and recruitment of Src and PKCdelta .
20553682	0	tyrosine	81,89	Src	56,59	tyrosine	Src	CHEBI:18186	83805(Tax:10116)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Vascular superoxide production by endothelin-1 requires Src non-receptor protein tyrosine kinase and MAPK activation .
21219825	0	tyrosine	15,23	Src	11,14	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	-LSB- Effect of Src tyrosine kinase inhibition on secretion of MMP-2 and MMP-9 by non-small cell lung_cancer cells -RSB- .
21420434	0	tyrosine	171,179	Src	167,170	tyrosine	Src	CHEBI:18186	20779(Tax:10090)	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Transglutaminase_2 null macrophages respond to lipopolysaccharide stimulation by elevated proinflammatory cytokine production due to an enhanced avb3 integrin-induced Src tyrosine kinase signaling .
21872572	0	tyrosine	19,27	Src	0,3	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Src family protein tyrosine kinases modulate L-type calcium current in human atrial myocytes .
22037769	0	tyrosine	24,32	Src	20,23	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Identification of a Src tyrosine kinase/SIAH2 E3 ubiquitin ligase pathway that regulates C/EBP expression and contributes to transformation of breast_tumor cells .
22308320	0	tyrosine	4,12	Src	0,3	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Src tyrosine kinase phosphorylation of nuclear receptor HNF4a correlates with isoform-specific loss of HNF4a in human colon_cancer .
22349424	0	tyrosine	4,12	Src	0,3	tyrosine	Src	CHEBI:18186	83805(Tax:10116)	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|compound|END_ENTITY	Src tyrosine kinase inhibition prevents pulmonary_ischemia-reperfusion-induced acute_lung_injury .
22388352	0	tyrosine	4,12	Src	0,3	tyrosine	Src	CHEBI:18186	20779(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Src tyrosine kinase inhibits apoptosis through the Erk1/2 - dependent degradation of the death accelerator Bik .
22516066	0	tyrosine	12,20	Src	8,11	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of Src tyrosine kinases in experimental pulmonary_hypertension .
23594268	0	tyrosine	27,35	Src	23,26	tyrosine	Src	CHEBI:18186	83805(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Roles Roles|nmod|END_ENTITY	Roles of mitochondrial Src tyrosine kinase and zinc in nitric_oxide-induced cardioprotection against ischemia/reperfusion injury .
23686837	0	tyrosine	51,59	Src	0,3	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	mediates|xcomp|START_ENTITY mediates|nsubj|END_ENTITY	Src mediates cigarette smoke-induced resistance to tyrosine kinase inhibitors in NSCLC cells .
24036910	0	tyrosine	19,27	Src	15,18	tyrosine	Src	CHEBI:18186	20779(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of Src tyrosine kinase and protein_kinase_C in the expression of macrophage_migration_inhibitory_factor induced by H2O2 in HL-1 mouse cardiac muscle cells .
24069562	0	tyrosine	81,89	Src	77,80	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	The cardioprotective effects of urocortin are mediated via activation of the Src tyrosine kinase-STAT3 pathway .
24269698	0	tyrosine	85,93	Src	81,84	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Trichothecene mycotoxins activate NLRP3 inflammasome through a P2X7_receptor and Src tyrosine kinase dependent pathway .
24336234	0	tyrosine	130,138	Src	126,129	tyrosine	Src	CHEBI:18186	83805(Tax:10116)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Serotonin contracts the rat mesenteric artery by inhibiting 4-aminopyridine-sensitive Kv channels via the 5-HT2A receptor and Src tyrosine kinase .
25372749	0	tyrosine	47,55	Src	20,23	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	family|nmod|START_ENTITY family|compound|END_ENTITY	Endocytosis and the Src family of non-receptor tyrosine kinases .
26919896	0	tyrosine	15,23	Src	4,7	tyrosine	Src	D014443	6714	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	The Src family tyrosine kinases , src and yes , have differential effects on inflammation-induced apoptosis in human pulmonary microvascular endothelial cells .
27002032	0	tyrosine	26,34	Src	4,7	tyrosine	Src	D014443	20779(Tax:10090)	Chemical	Gene	kinases|compound|START_ENTITY family|nmod|kinases family|compound|END_ENTITY	The Src family of protein tyrosine kinases : regulation and functions .
7478513	0	tyrosine	22,30	Src	18,21	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Regulation of the Src tyrosine kinase and Syp tyrosine phosphatase by their cellular association .
7520528	0	tyrosine	91,99	Src	72,75	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	START_ENTITY|nsubj|interactions interactions|nmod|domains domains|nmod|protein protein|compound|END_ENTITY	Physical and functional interactions between SH2 and SH3 domains of the Src family protein tyrosine kinase p59fyn .
7530722	0	tyrosine	84,92	Src	112,115	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Cell spreading in Colo 201 by staurosporin is alpha 3 beta_1_integrin-mediated with tyrosine phosphorylation of Src and tensin .
7537495	0	tyrosine	84,92	Src	50,53	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	kinase|nmod|START_ENTITY kinase|compound|END_ENTITY	Autophosphorylation activity and association with Src family kinase of Sky receptor tyrosine kinase .
7685657	0	tyrosine	72,80	Src	61,64	tyrosine	Src	CHEBI:18186	20779(Tax:10090)	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Disruption of the csk gene , encoding a negative regulator of Src family tyrosine kinases , leads to neural tube defects and embryonic_lethality in mice .
7823926	0	tyrosine	85,93	Src	66,69	tyrosine	Src	CHEBI:18186	20779(Tax:10090)	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	DNA synthesis induced by some but not all growth factors requires Src family protein tyrosine kinases .
7896837	0	tyrosine	175,183	Src	154,157	tyrosine	Src	CHEBI:18186	20779(Tax:10090)	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	A membrane proximal domain of the human interleukin-3 receptor beta_c subunit that signals DNA synthesis in NIH 3T3 cells specifically binds a complex of Src and Janus family tyrosine kinases and phosphatidylinositol 3-kinase .
8049488	0	tyrosine	26,34	Src	4,7	tyrosine	Src	CHEBI:18186	20779(Tax:10090)	Chemical	Gene	kinases|compound|START_ENTITY family|nmod|kinases family|compound|END_ENTITY	The Src family of protein tyrosine kinases : regulation and functions .
8356071	0	tyrosine	15,23	Src	4,7	tyrosine	Src	CHEBI:18186	20779(Tax:10090)	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	The Src family tyrosine kinases are required for platelet-derived growth factor-mediated signal transduction in NIH 3T3 cells .
8668162	0	tyrosine	32,40	Src	21,24	tyrosine	Src	CHEBI:18186	20779(Tax:10090)	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Regulation of Btk by Src family tyrosine kinases .
8900189	0	tyrosine	82,90	Src	78,81	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	SMAP , an Smg_GDS-associating protein having arm repeats and phosphorylated by Src tyrosine kinase .
8910575	0	tyrosine	4,12	Src	0,3	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Src tyrosine kinases , Galpha subunits , and H-Ras share a common membrane-anchored scaffolding protein , caveolin .
8910575	1	tyrosine	178,186	Src	174,177	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Caveolin binding negatively regulates the auto-activation of Src tyrosine kinases .
8940409	0	tyrosine	4,12	Src	0,3	tyrosine	Src	CHEBI:18186	20779(Tax:10090)	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Src tyrosine kinase activity is related to luteinizing hormone responsiveness : genetic manipulations using mouse MA10 Leydig cells .
8953041	0	tyrosine	19,27	Src	15,18	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	START_ENTITY|nsubj|Association Association|nmod|END_ENTITY	Association of Src tyrosine kinase with a human potassium channel mediated by SH3 domain .
9027367	0	tyrosine	4,12	Src	0,3	tyrosine	Src	CHEBI:18186	83805(Tax:10116)	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Src tyrosine kinase activity in rat thecal-interstitial cells and mouse TM3 Leydig cells is positively associated with cAMP-specific phosphodiesterase activity .
9177269	0	tyrosine	28,36	Src	17,20	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Palmitylation of Src family tyrosine kinases regulates functional interaction with a B cell substrate .
9242445	0	tyrosine	4,12	Src	0,3	tyrosine	Src	CHEBI:18186	20779(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Src tyrosine kinase mediates stimulation of Raf-1 and mitogen-activated_protein kinase by the tumor promoter thapsigargin .
9579582	0	tyrosine	132,140	Src	128,131	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Interferon-alpha_and _ - gamma inhibit the growth and neoplastic potential of v-src-transformed human epithelial cells by reducing Src tyrosine kinase activity .
9731575	0	tyrosine	26,34	Src	22,25	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|END_ENTITY	Altered regulation of Src tyrosine kinase by transforming growth factor beta1 in a human hepatoma cell line .
9987835	0	tyrosine	159,167	Src	147,150	tyrosine	Src	CHEBI:18186	6714	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Different inhibitory effects of 5-S-glutathionyl-beta-alanyl-L-dopa -LRB- 5-S-GA-L-D -RRB- analogues on autophosphorylation and substrate phosphorylation of Src protein tyrosine kinase .
9254654	0	tyrosine	89,97	Src_homology_2_phosphatase_2	53,81	tyrosine	Src homology 2 phosphatase 2	CHEBI:18186	5781	Chemical	Gene	phosphatase|amod|START_ENTITY END_ENTITY|amod|phosphatase	Src homology 2 protein tyrosine phosphatase -LRB- SHPTP2 -RRB- / Src_homology_2_phosphatase_2 -LRB- SHP2 -RRB- tyrosine phosphatase is a positive regulator of the interleukin 5 receptor signal transduction pathways leading to the prolongation of eosinophil survival .
7935409	0	tyrosine	20,28	Srm	37,40	tyrosine	Srm	CHEBI:18186	20810(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	A novel nonreceptor tyrosine kinase , Srm : cloning and targeted disruption .
8756652	0	tyrosine	92,100	Stat1	122,127	tyrosine	Stat1	CHEBI:18186	20846(Tax:10090)	Chemical	Gene	dephosphorylation|amod|START_ENTITY dephosphorylation|nmod|END_ENTITY	Enhancement of antiproliferative activity of gamma interferon by the specific inhibition of tyrosine dephosphorylation of Stat1 .
12082540	3	tyrosine	492,500	Stat3	520,525	tyrosine	Stat3	CHEBI:18186	6774	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Our results demonstrate that expression of wt p53 but not mutant p53 significantly reduced tyrosine phosphorylation of Stat3 and inhibited Stat3 DNA binding activity in both DU145 and Tsu_prostate_cancer cell lines that express constitutively active Stat3 .
12543077	0	tyrosine	68,76	Stat3	53,58	tyrosine	Stat3	CHEBI:18186	6774	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	SHP2 regulates IL-2 induced MAPK activation , but not Stat3 or Stat5 tyrosine phosphorylation , in cutaneous_T_cell_lymphoma cells .
16427042	0	tyrosine	45,53	Stat3	29,34	tyrosine	Stat3	CHEBI:18186	6774	Chemical	Gene	START_ENTITY|nsubj|evaluation evaluation|nmod|END_ENTITY	Systemic evaluation of total Stat3 and Stat3 tyrosine phosphorylation in normal human tissues .
17404037	6	tyrosine	885,893	Stat3	913,918	tyrosine	Stat3	CHEBI:18186	6774	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Recombinant IL-10 -LRB- rIL-10 -RRB- increased the tyrosine phosphorylation of Stat3 , upregulated the levels of Fer , and increased the association of Fer with phosphorylated Stat3 -LRB- pYStat3 -RRB- .
7776967	0	tyrosine	56,64	Stat3	99,104	tyrosine	Stat3	CHEBI:18186	6774	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	In vivo growth_hormone treatment rapidly stimulates the tyrosine phosphorylation and activation of Stat3 .
8555464	0	tyrosine	23,31	Stat3	51,56	tyrosine	Stat3	CHEBI:18186	6774	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Thrombopoietin induces tyrosine phosphorylation of Stat3 and Stat5 in human blood platelets .
8702638	0	tyrosine	80,88	Stat5	108,113	tyrosine	Stat5	CHEBI:18186	6776	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	An epidermal_growth_factor_receptor / Jak2 tyrosine kinase domain chimera induces tyrosine phosphorylation of Stat5 and transduces a growth signal in hematopoietic cells .
9516478	0	tyrosine	35,43	Stat5	29,34	tyrosine	Stat5	CHEBI:18186	6776	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Prolactin_receptor regulates Stat5 tyrosine phosphorylation and nuclear translocation by two separate pathways .
8961260	0	tyrosine	35,43	Stat5a	14,20	tyrosine	Stat5a	CHEBI:18186	20850(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY END_ENTITY|nmod|phosphorylation	Activation of Stat5a and Stat5b by tyrosine phosphorylation is tightly linked to mammary gland differentiation .
7538664	0	tyrosine	36,44	Stat_5	90,96	tyrosine	Stat 5	CHEBI:18186	20850(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Epidermal_growth_factor induces the tyrosine phosphorylation and nuclear translocation of Stat_5 in mouse liver .
1381360	0	tyrosine	28,36	Steel_factor	0,12	tyrosine	Steel factor	CHEBI:18186	4254	Chemical	Gene	phosphorylation|amod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Steel_factor stimulates the tyrosine phosphorylation of the proto-oncogene product , p95vav , in human hemopoietic cells .
9092574	0	tyrosine	21,29	Steel_factor	0,12	tyrosine	Steel factor	CHEBI:18186	4254	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Steel_factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit , phosphatidylinositol 3-kinase , and p120 -LRB- CBL -RRB- .
1707188	0	tyrosine	81,89	Stem_cell_factor	0,16	tyrosine	Stem cell factor	CHEBI:18186	4254	Chemical	Gene	receptor|compound|START_ENTITY factor|nmod|receptor END_ENTITY|appos|factor	Stem_cell_factor -LRB- SCF -RRB- , a novel hematopoietic growth factor and ligand for c-kit tyrosine kinase receptor , maps on human chromosome 12 between 12q14 .3 and 12qter .
10508511	0	tyrosine	49,57	Stk	36,39	tyrosine	Fv2	CHEBI:18186	19882(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Fv2 encodes a truncated form of the Stk receptor tyrosine kinase .
7654712	0	tyrosine	70,78	Stp1	92,96	tyrosine	Stp1	CHEBI:18186	852074(Tax:4932)	Chemical	Gene	START_ENTITY|dobj|phosphatase phosphatase|appos|END_ENTITY	Purification and characterization of the low molecular weight protein tyrosine phosphatase , Stp1 , from the fission_yeast Schizosaccharomyces_pombe .
8780727	0	tyrosine	83,91	Suc1-associated_neurotrophic_factor_target	0,42	tyrosine	Suc1-associated neurotrophic factor target	CHEBI:18186	10818	Chemical	Gene	START_ENTITY|nsubj|protein protein|amod|END_ENTITY	Suc1-associated_neurotrophic_factor_target -LRB- SNT -RRB- protein is a major FGF-stimulated tyrosine phosphorylated 90-kDa protein which binds to the SH2 domain of GRB2 .
10072516	0	tyrosine	121,129	Syk	117,120	tyrosine	Syk	CHEBI:18186	20963(Tax:10090)	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Expression of dominant-negative src-homology domain 2-containing protein tyrosine phosphatase-1 results in increased Syk tyrosine kinase activity and B cell activation .
10339479	0	tyrosine	43,51	Syk	31,34	tyrosine	Syk	CHEBI:18186	6850	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	A common signaling pathway via Syk and Lyn tyrosine kinases generated from capping of the sialomucins CD34 and CD43 in immature hematopoietic cells .
10427998	0	tyrosine	113,121	Syk	98,101	tyrosine	Syk	CHEBI:18186	6850	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	CD28 ligation induces rapid tyrosine phosphorylation of the linker molecule LAT in the absence of Syk and ZAP-70 tyrosine phosphorylation .
10453000	0	tyrosine	83,91	Syk	71,74	tyrosine	Syk	CHEBI:18186	6850	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Pre-T cell receptor signals are responsible for the down-regulation of Syk protein tyrosine kinase expression .
10617633	0	tyrosine	78,86	Syk	74,77	tyrosine	Syk	CHEBI:18186	6850	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The RING finger domain of Cbl is essential for negative regulation of the Syk tyrosine kinase .
10764819	0	tyrosine	131,139	Syk	127,130	tyrosine	Syk	CHEBI:18186	6850	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Mildly oxidized low density lipoprotein rapidly stimulates via activation of the lysophosphatidic_acid receptor Src family and Syk tyrosine kinases and Ca2 + influx in human platelets .
10942405	0	tyrosine	60,68	Syk	48,51	tyrosine	Syk	CHEBI:18186	6850	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Sequential phosphorylation of protein band 3 by Syk and Lyn tyrosine kinases in intact human erythrocytes : identification of primary and secondary phosphorylation sites .
10963601	0	tyrosine	8,16	Syk	4,7	tyrosine	Syk	CHEBI:18186	6850	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The Syk tyrosine kinase suppresses malignant growth of human breast_cancer cells .
11698299	0	tyrosine	45,53	Syk	41,44	tyrosine	Syk	CHEBI:18186	6850	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Deoxygenation of sickle cells stimulates Syk tyrosine kinase and inhibits a membrane tyrosine phosphatase .
12009018	0	tyrosine	76,84	Syk	72,75	tyrosine	Syk	CHEBI:18186	6850	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Prostaglandin_E2 induces interaction between hSlo potassium channel and Syk tyrosine kinase in osteosarcoma cells .
12145291	0	tyrosine	18,26	Syk	14,17	tyrosine	Syk	CHEBI:18186	25155(Tax:10116)	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Activation of Syk tyrosine kinase is required for c-Cbl-mediated ubiquitination of Fcepsilon RI and Syk in RBL cells .
12188037	0	tyrosine	60,68	Syk	56,59	tyrosine	Syk	CHEBI:18186	427272(Tax:9031)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Selective pharmacological inhibitors reveal the role of Syk tyrosine kinase , phospholipase C , phosphatidylinositol-3 ' - kinase , and p38 mitogen-activated protein kinase in Fc_receptor-mediated signaling of chicken heterophil degranulation .
12209081	0	tyrosine	39,47	Syk	35,38	tyrosine	Syk	CHEBI:18186	6850	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|END_ENTITY	Proteasome-dependent regulation of Syk tyrosine kinase levels in human basophils .
12470302	0	tyrosine	22,30	Syk	18,21	tyrosine	Syk	CHEBI:18186	20963(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Activation of the Syk tyrosine kinase is insufficient for downstream signal transduction in B lymphocytes .
12517949	0	tyrosine	32,40	Syk	20,23	tyrosine	Syk	CHEBI:18186	6850	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	A critical role for Syk protein tyrosine kinase in Fc receptor-mediated antigen presentation and induction of dendritic cell maturation .
12739161	0	tyrosine	54,62	Syk	34,37	tyrosine	Syk	CHEBI:18186	20963(Tax:10090)	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Regulation of K-Cl cotransport by Syk and Src protein tyrosine kinases in deoxygenated sickle cells .
14656219	0	tyrosine	39,47	Syk	83,86	tyrosine	Syk	CHEBI:18186	6850	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Glycoproteins VI and Ib-IX-V stimulate tyrosine phosphorylation of tyrosine kinase Syk and phospholipase_Cgamma2 at distinct sites .
14673144	0	tyrosine	26,34	Syk	14,17	tyrosine	Syk	CHEBI:18186	6850	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Activation of Syk protein tyrosine kinase in response to osmotic stress requires interaction with p21-activated protein kinase Pak2/gamma-PAK .
15062056	0	tyrosine	15,23	Syk	31,34	tyrosine	Syk	CHEBI:18186	6850	Chemical	Gene	Expression|nmod|START_ENTITY kinase|nsubj|Expression kinase|dobj|END_ENTITY	-LSB- Expression of tyrosine kinase Syk in breast_cancer and their clinical significance -RSB- .
15073337	0	tyrosine	146,154	Syk	142,145	tyrosine	Syk	CHEBI:18186	20963(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The immunomodulatory adapter proteins DAP12 and Fc_receptor_gamma-chain -LRB- FcRgamma -RRB- regulate development of functional osteoclasts through the Syk tyrosine kinase .
15240695	0	tyrosine	26,34	Syk	14,17	tyrosine	Syk	CHEBI:18186	6850	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	TNF activates Syk protein tyrosine kinase leading to TNF-induced MAPK activation , NF-kappaB activation , and apoptosis .
15457545	0	tyrosine	87,95	Syk	75,78	tyrosine	Syk	CHEBI:18186	6850	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	A cyclic_adenosine_3 ' ,5 ' - monophosphate-induced tyrosine phosphorylation of Syk protein tyrosine kinase in the flagella of boar spermatozoa .
15557085	0	tyrosine	4,12	Syk	0,3	tyrosine	Syk	CHEBI:18186	6850	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Syk tyrosine kinase participates in beta1-integrin signaling and inflammatory responses in airway epithelial cells .
15795233	0	tyrosine	109,117	Syk	97,100	tyrosine	Syk	CHEBI:18186	6850	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Thrombin-induced tyrosine phosphorylation of HS1 in human platelets is sequentially catalyzed by Syk and Lyn tyrosine kinases and associated with the cellular migration of the protein .
15921466	0	tyrosine	18,26	Syk	35,38	tyrosine	Syk	CHEBI:18186	6850	Chemical	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	Inhibition of the tyrosine kinase , Syk , analyzed by stepwise_nonparametric_regression .
16185147	0	tyrosine	7,15	Syk	24,27	tyrosine	Syk	CHEBI:18186	6850	Chemical	Gene	START_ENTITY|dobj|kinase kinase|appos|END_ENTITY	Spleen tyrosine kinase -LRB- Syk -RRB- as a novel target for allergic_asthma and rhinitis .
16322234	0	tyrosine	8,16	Syk	4,7	tyrosine	Syk	CHEBI:18186	6850	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The Syk tyrosine kinase localizes to the centrosomes and negatively affects mitotic progression .
16410013	0	tyrosine	98,106	Syk	94,97	tyrosine	Syk	CHEBI:18186	6850	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Structural basis for the requirement of two phosphotyrosine residues in signaling mediated by Syk tyrosine kinase .
16431925	0	tyrosine	4,12	Syk	0,3	tyrosine	Syk	CHEBI:18186	6850	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Syk tyrosine kinase mediates Epstein-Barr_virus latent membrane protein 2A-induced cell migration in epithelial cells .
16442709	0	tyrosine	8,16	Syk	4,7	tyrosine	Syk	CHEBI:18186	6850	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The Syk tyrosine kinase : a new negative regulator in tumor growth and progression .
17182546	0	tyrosine	7,15	Syk	24,27	tyrosine	Syk	CHEBI:18186	20963(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	Spleen tyrosine kinase -LRB- Syk -RRB- , a novel target of curcumin , is required for B_lymphoma growth .
17672952	0	tyrosine	21,29	Syk	38,41	tyrosine	Syk	CHEBI:18186	6850	Chemical	Gene	START_ENTITY|dobj|gene gene|appos|END_ENTITY	-LSB- Functions of spleen tyrosine kinase -LRB- Syk -RRB- gene and its correlation to neoplasms -RSB- .
17675467	0	tyrosine	41,49	Syk	37,40	tyrosine	Syk	CHEBI:18186	25155(Tax:10116)	Chemical	Gene	level|compound|START_ENTITY level|compound|END_ENTITY	The adaptor molecule CIN85 regulates Syk tyrosine kinase level by activating the ubiquitin-proteasome degradation pathway .
17699797	0	tyrosine	4,12	Syk	0,3	tyrosine	Syk	CHEBI:18186	6850	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Syk tyrosine kinase is linked to cell motility and progression in squamous_cell_carcinomas_of_the_head_and_neck .
18353872	0	tyrosine	152,160	Syk	148,151	tyrosine	Syk	CHEBI:18186	6850	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	High glucose-induced NF-kappaB activation occurs via tyrosine phosphorylation of IkappaBalpha in human glomerular endothelial cells : involvement of Syk tyrosine kinase .
19435818	0	tyrosine	20,28	Syk	36,39	tyrosine	Syk	CHEBI:18186	6850	Chemical	Gene	Role|nmod|START_ENTITY kinase|nsubj|Role kinase|dobj|END_ENTITY	Role of the protein tyrosine kinase Syk in regulating cell-cell adhesion and motility in breast_cancer cells .
20415544	0	tyrosine	61,69	Syk	78,81	tyrosine	Syk	CHEBI:18186	102145713	Chemical	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	Contribution of gut bacteria to the metabolism of the spleen tyrosine kinase -LRB- Syk -RRB- inhibitor R406 in cynomolgus_monkey .
20729208	0	tyrosine	80,88	Syk	97,100	tyrosine	Syk	CHEBI:18186	6850	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	Heme amplifies the innate immune response to microbial molecules through spleen tyrosine kinase -LRB- Syk -RRB- - dependent reactive oxygen species generation .
21382613	0	tyrosine	117,125	Syk	134,137	tyrosine	Syk	CHEBI:18186	6850	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	Antibody-mediated platelet phagocytosis by human macrophages is inhibited by siRNA specific for sequences in the SH2 tyrosine kinase , Syk .
22000807	0	tyrosine	12,20	Syk	0,3	tyrosine	Syk	CHEBI:18186	6850	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Syk protein tyrosine kinase involves PECAM-1 signaling through tandem immunotyrosine inhibitory motifs in human THP-1 macrophages .
22301676	0	tyrosine	7,15	Syk	24,27	tyrosine	Syk	CHEBI:18186	20963(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	Spleen tyrosine kinase -LRB- Syk -RRB- is a potent target for GvHD prevention at different cellular levels .
22776089	0	tyrosine	90,98	Syk	106,109	tyrosine	Syk	CHEBI:18186	6850	Chemical	Gene	kinase|amod|START_ENTITY END_ENTITY|amod|kinase	Complement receptor-3 negatively regulates the phagocytosis of degenerated myelin through tyrosine kinase Syk and cofilin .
22900966	0	tyrosine	126,134	Syk	143,146	tyrosine	Syk	CHEBI:18186	6850	Chemical	Gene	START_ENTITY|dobj|inhibitors inhibitors|appos|END_ENTITY	Exploring the role of water molecules for docking and receptor guided 3D-QSAR analysis of naphthyridine derivatives as spleen tyrosine kinase -LRB- Syk -RRB- inhibitors .
23515313	0	tyrosine	7,15	Syk	24,27	tyrosine	Syk	CHEBI:18186	6850	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	Spleen tyrosine kinase -LRB- Syk -RRB- - dependent calcium signals mediate efficient CpG-induced exocytosis of tumor_necrosis_factor_a -LRB- TNFa -RRB- in innate immune cells .
23960082	0	tyrosine	35,43	Syk	52,55	tyrosine	Syk	CHEBI:18186	6850	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	Tyrosine phosphorylation on spleen tyrosine kinase -LRB- Syk -RRB- is differentially regulated in human and murine platelets by protein kinase C isoforms .
24486434	0	tyrosine	117,125	Syk	134,137	tyrosine	Syk	CHEBI:18186	6850	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	Sesquiterpene dimmer -LRB- DSF-27 -RRB- inhibits the release of neuroinflammatory mediators from microglia by targeting spleen tyrosine kinase -LRB- Syk -RRB- and Janus_kinase_2 -LRB- Jak2 -RRB- : Two major non-receptor tyrosine signaling proteins involved in inflammatory events .
26148346	0	tyrosine	7,15	Syk	24,27	tyrosine	Syk	D014443	20963(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	Spleen tyrosine kinase -LRB- Syk -RRB- inhibitor fostamatinib limits tissue_damage and fibrosis in a bleomycin-induced scleroderma_mouse model .
26297607	0	tyrosine	59,67	Syk	76,79	tyrosine	Syk	D014443	6850	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	Borrelia-induced cytokine production is mediated by spleen tyrosine kinase -LRB- Syk -RRB- but is Dectin-1 and Dectin-2 independent .
7513017	0	tyrosine	33,41	Syk	0,3	tyrosine	Syk	CHEBI:18186	20963(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY END_ENTITY|nmod|kinase	Syk activation by the Src-family tyrosine kinase in the B cell receptor signaling .
8663235	0	tyrosine	4,12	Syk	0,3	tyrosine	Syk	CHEBI:18186	6850	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Syk tyrosine kinase is required for immunoreceptor tyrosine activation motif-dependent actin assembly .
8691151	0	tyrosine	28,36	Syk	16,19	tyrosine	Syk	CHEBI:18186	25155(Tax:10116)	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Transfection of Syk protein tyrosine kinase reconstitutes high affinity IgE receptor-mediated degranulation in a Syk-negative variant of rat basophilic_leukemia RBL-2H3 cells .
8691151	1	tyrosine	286,294	Syk	329,332	tyrosine	Syk	CHEBI:18186	25155(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Aggregation of the high affinity receptor for immunoglobulin E -LRB- Fc_epsilon_RI -RRB- on mast cells results in rapid tyrosine phosphorylation and activation of Syk , a cytoplasmic protein tyrosine kinase .
8691151	1	tyrosine	356,364	Syk	329,332	tyrosine	Syk	CHEBI:18186	25155(Tax:10116)	Chemical	Gene	kinase|compound|START_ENTITY END_ENTITY|appos|kinase	Aggregation of the high affinity receptor for immunoglobulin E -LRB- Fc_epsilon_RI -RRB- on mast cells results in rapid tyrosine phosphorylation and activation of Syk , a cytoplasmic protein tyrosine kinase .
8790395	0	tyrosine	79,87	Syk	75,78	tyrosine	Syk	CHEBI:18186	20963(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Disruption of epithelial gamma delta T cell repertoires by mutation of the Syk tyrosine kinase .
8947048	0	tyrosine	16,24	Syk	4,7	tyrosine	Syk	CHEBI:18186	6850	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The Syk protein tyrosine kinase can function independently of CD45 or Lck in T_cell_antigen_receptor signaling .
9000133	0	tyrosine	22,30	Syk	38,41	tyrosine	Syk	CHEBI:18186	6850	Chemical	Gene	role|nmod|START_ENTITY kinase|nsubj|role kinase|dobj|END_ENTITY	Critical role for the tyrosine kinase Syk in signalling through the high affinity IgE receptor of mast cells .
9022035	0	tyrosine	42,50	Syk	22,25	tyrosine	Syk	CHEBI:18186	25155(Tax:10116)	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Direct interaction of Syk and Lyn protein tyrosine kinases in rat basophilic_leukemia cells activated via type I Fc epsilon receptors .
9103201	0	tyrosine	73,81	Syk	69,72	tyrosine	Syk	CHEBI:18186	6850	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The product of the proto-oncogene_c-cbl : a negative regulator of the Syk tyrosine kinase .
9233602	0	tyrosine	103,111	Syk	99,102	tyrosine	Syk	CHEBI:18186	20963(Tax:10090)	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Cross-linking of the IgM receptor induces rapid translocation of IgM-associated Ig_alpha , Lyn , and Syk tyrosine kinases to the membrane skeleton .
9324357	0	tyrosine	87,95	Syk	75,78	tyrosine	Syk	CHEBI:18186	20963(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Restoration of thymocyte development and function in zap-70 - / - mice by the Syk protein tyrosine kinase .
9396765	0	tyrosine	24,32	Syk	20,23	tyrosine	Syk	CHEBI:18186	20963(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Functional role for Syk tyrosine kinase in natural killer cell-mediated natural cytotoxicity .
9396770	0	tyrosine	4,12	Syk	0,3	tyrosine	Syk	CHEBI:18186	6850	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Syk tyrosine kinase is required for the positive selection of immature B cells into the recirculating B cell pool .
9551966	0	tyrosine	22,30	Syk	11,14	tyrosine	Syk	CHEBI:18186	6850	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Harnessing Syk family tyrosine kinases as signaling domains for chimeric single chain of the variable domain receptors : optimal design for T cell activation .
9632805	0	tyrosine	16,24	Syk	4,7	tyrosine	Syk	CHEBI:18186	20963(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The Syk protein tyrosine kinase is essential for Fcgamma receptor signaling in macrophages and neutrophils .
9730884	0	tyrosine	4,12	Syk	0,3	tyrosine	Syk	CHEBI:18186	6850	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Syk tyrosine kinase and B cell antigen receptor -LRB- BCR -RRB- immunoglobulin-alpha subunit determine BCR-mediated major histocompatibility complex class II-restricted antigen presentation .
9850860	0	tyrosine	26,34	Syk	4,7	tyrosine	Syk	CHEBI:18186	6850	Chemical	Gene	family|nmod|START_ENTITY family|compound|END_ENTITY	The Syk family of protein tyrosine kinases in T-cell activation and development .
8639815	0	tyrosine	113,121	Syp	109,112	tyrosine	Syp	CHEBI:18186	20977(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|compound|END_ENTITY	Tyrosine 425 within the activated erythropoietin receptor binds Syp , reduces the erythropoietin required for Syp tyrosine phosphorylation , and promotes mitogenesis .
8770882	0	tyrosine	82,90	Syp	126,129	tyrosine	Syp	CHEBI:18186	24804(Tax:10116)	Chemical	Gene	phosphorylated|advmod|START_ENTITY phosphorylated|nmod|END_ENTITY	A 60-kilodalton protein in rat hepatoma cells overexpressing insulin_receptor was tyrosine phosphorylated and associated with Syp , phophatidylinositol 3-kinase , and Grb2 in an insulin-dependent manner .
2432431	0	tyrosine	9,17	T-cell_receptor	37,52	tyrosine	T-cell receptor	CHEBI:18186	328483(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Abnormal tyrosine phosphorylation on T-cell_receptor in lymphoproliferative_disorders .
2477711	0	tyrosine	66,74	T-cell_receptor_zeta_chain	98,124	tyrosine	T-cell receptor zeta chain	CHEBI:18186	919	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Intrathymic signalling in immature CD4 + CD8 + thymocytes results in tyrosine phosphorylation of the T-cell_receptor_zeta_chain .
26867565	0	tyrosine	13,21	TAM	0,3	tyrosine	TAM	D014443	8205	Chemical	Gene	START_ENTITY|nsubj|receptor receptor|compound|END_ENTITY	TAM receptor tyrosine kinase function and the immunopathology of liver_disease .
20421975	0	tyrosine	8,16	TC-PTP	31,37	tyrosine	TC-PTP	CHEBI:18186	19255(Tax:10090)	Chemical	Gene	phosphatases|compound|START_ENTITY phosphatases|appos|END_ENTITY	Protein tyrosine phosphatases , TC-PTP , SHP1 , and SHP2 , cooperate in rapid dephosphorylation of Stat3 in keratinocytes following UVB irradiation .
18840653	0	tyrosine	12,20	TCPTP	33,38	tyrosine	TCPTP	CHEBI:18186	5771	Chemical	Gene	phosphatase|nsubj|START_ENTITY phosphatase|ccomp|controls controls|nsubj|END_ENTITY	The protein tyrosine phosphatase TCPTP controls VEGFR2 signalling .
20084063	0	tyrosine	55,63	TCR	89,92	tyrosine	TCR	CHEBI:18186	6962	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	The right team at the right time to go for a home run : tyrosine kinase activation by the TCR .
7522245	0	tyrosine	91,99	TCR	87,90	tyrosine	TCR	CHEBI:18186	6962	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|compound|END_ENTITY	gp120 ligation of CD4 induces p56lck activation and TCR desensitization independent of TCR tyrosine phosphorylation .
8395828	0	tyrosine	69,77	TEK	56,59	tyrosine	TEK	CHEBI:18186	21687(Tax:10090)	Chemical	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	Molecular cloning and characterization of mouse TIE and TEK receptor tyrosine kinase genes and their expression in hematopoietic stem cells .
9723709	0	tyrosine	33,41	TEK	20,23	tyrosine	TEK	CHEBI:18186	7010	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Characterization of TEK receptor tyrosine kinase and its ligands , Angiopoietins , in human hematopoietic progenitor cells .
9187108	0	tyrosine	72,80	TEP1	0,4	tyrosine	TEP1	CHEBI:18186	7011	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|nsubj|END_ENTITY	TEP1 , encoded by a candidate tumor suppressor locus , is a novel protein tyrosine phosphatase regulated by transforming_growth_factor_beta .
21251937	0	tyrosine	107,115	TGF-b	20,25	tyrosine	TGF-b	CHEBI:18186	7040	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of PDGF , TGF-b , and Abl signaling and reduction of liver_fibrosis by the small molecule Bcr-Abl tyrosine kinase antagonist Nilotinib .
11236902	0	tyrosine	58,66	TGF-beta	0,8	tyrosine	TGF-beta	CHEBI:18186	59086(Tax:10116)	Chemical	Gene	phosphatases|amod|START_ENTITY upregulating|dobj|phosphatases signaling|advcl|upregulating TCR-mediated|xcomp|signaling TCR-mediated|nsubj|abrogates abrogates|amod|END_ENTITY	TGF-beta abrogates TCR-mediated signaling by upregulating tyrosine phosphatases in T cells .
16258068	0	tyrosine	24,32	TGF-beta	51,59	tyrosine	TGF-beta	D014443	7040	Chemical	Gene	kinase|amod|START_ENTITY suppresses|nsubj|kinase suppresses|dobj|END_ENTITY	The ETV6-NTRK3 chimeric tyrosine kinase suppresses TGF-beta signaling by inactivating the TGF-beta_type_II_receptor .
9200453	0	tyrosine	31,39	TGF-beta	0,8	tyrosine	TGF-beta	CHEBI:18186	7040	Chemical	Gene	START_ENTITY|nsubj|IL-2-induced IL-2-induced|amod|END_ENTITY	TGF-beta inhibits IL-2-induced tyrosine phosphorylation and activation of Jak-1 and Stat_5 in T lymphocytes .
18762249	0	tyrosine	89,97	TGF-beta-activated_kinase-1	42,69	tyrosine	TGF-beta-activated kinase-1	CHEBI:18186	6885	Chemical	Gene	START_ENTITY|nsubj|interaction interaction|nmod|END_ENTITY	Wnt-ligand-dependent interaction of TAK1 -LRB- TGF-beta-activated_kinase-1 -RRB- with the receptor tyrosine kinase Ror2 modulates canonical Wnt-signalling .
11960349	0	tyrosine	37,45	TGF-beta1	65,74	tyrosine	TGF-beta1	CHEBI:18186	7040	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Downregulation of IL-6-induced STAT3 tyrosine phosphorylation by TGF-beta1 is mediated by caspase-dependent and - independent processes .
10995770	0	tyrosine	58,66	TIE-1	75,80	tyrosine	TIE-1	CHEBI:18186	7075	Chemical	Gene	interaction|nmod|START_ENTITY Evidence|nmod|interaction kinases|nsubj|Evidence kinases|xcomp|END_ENTITY	Evidence for heterotypic interaction between the receptor tyrosine kinases TIE-1 and TIE-2 .
17676829	0	tyrosine	76,84	TIE-2	58,63	tyrosine	TIE-2	CHEBI:18186	7010	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Discovery of novel benzimidazoles as potent inhibitors of TIE-2 and VEGFR-2 tyrosine kinase receptors .
18308565	0	tyrosine	133,141	TIE-2	106,111	tyrosine	TIE-2	CHEBI:18186	7010	Chemical	Gene	kinases|amod|START_ENTITY kinases|compound|END_ENTITY	Design and synthesis of dihydroindazolo -LSB- 5,4-a -RSB- pyrrolo -LSB- 3,4-c -RSB- carbazole_oximes as potent dual inhibitors of TIE-2 and VEGF-R2 receptor tyrosine kinases .
20430619	0	tyrosine	63,71	TIE-2	40,45	tyrosine	TIE-2	CHEBI:18186	7010	Chemical	Gene	analogs|parataxis|START_ENTITY analogs|nmod|END_ENTITY	8-THP-DHI analogs as potent Type I dual TIE-2 / VEGF-R2 receptor tyrosine kinase inhibitors .
9683559	0	tyrosine	23,31	TIE1	0,4	tyrosine	TIE1	CHEBI:18186	21846(Tax:10090)	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	TIE1 and TIE2 receptor tyrosine kinases inversely regulate embryonic angiogenesis by the mechanism of intussusceptive microvascular growth .
26884170	0	tyrosine	16,24	TIE2	32,36	tyrosine	TIE2	D014443	21687(Tax:10090)	Chemical	Gene	control|nmod|START_ENTITY kinase|nsubj|control kinase|dobj|manifestations manifestations|compound|END_ENTITY	Gene control of tyrosine kinase TIE2 and vascular manifestations of infections .
15502848	0	tyrosine	20,28	TLR3	15,19	tyrosine	TLR3	CHEBI:18186	7098	Chemical	Gene	START_ENTITY|nsubj|roles roles|nmod|END_ENTITY	Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling .
17392283	0	tyrosine	13,21	TLR4	8,12	tyrosine	TLR4	CHEBI:18186	7099	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of TLR4 tyrosine phosphorylation in signal transduction and endotoxin tolerance .
16891393	0	tyrosine	20,28	TNF-alpha	0,9	tyrosine	TNF-alpha	CHEBI:18186	7124	Chemical	Gene	START_ENTITY|nsubj|increases increases|amod|END_ENTITY	TNF-alpha increases tyrosine phosphorylation of vascular_endothelial_cadherin and opens the paracellular pathway through fyn activation in human lung endothelia .
7722327	0	tyrosine	18,26	TNF-alpha	0,9	tyrosine	TNF-alpha	CHEBI:18186	7124	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	TNF-alpha induces tyrosine phosphorylation of mitogen-activated protein kinase in adherent human neutrophils .
12057926	0	tyrosine	26,34	TRAP	0,4	tyrosine	TRAP	CHEBI:18186	100187907	Chemical	Gene	phosphorylation|compound|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	TRAP induces more intense tyrosine phosphorylation than thrombin with differential ultrastructural features .
9259409	0	tyrosine	30,38	TRK	17,20	tyrosine	TRK	CHEBI:18186	18211(Tax:10090)	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	CEP-751 inhibits TRK receptor tyrosine kinase activity in vitro exhibits anti-tumor activity .
7789988	0	tyrosine	56,64	TRK-B	50,55	tyrosine	TRK-B	CHEBI:18186	4915	Chemical	Gene	START_ENTITY|nsubj|localization localization|nmod|END_ENTITY	Cloning and chromosomal localization of the human TRK-B tyrosine kinase receptor gene -LRB- NTRK2 -RRB- .
10233776	0	tyrosine	37,45	TRKA	67,71	tyrosine	TRKA	CHEBI:18186	4914	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|gene gene|compound|END_ENTITY	A novel point mutation affecting the tyrosine kinase domain of the TRKA gene in a family with congenital_insensitivity to pain with anhidrosis .
12812762	0	tyrosine	2,10	TRPV1	52,57	tyrosine	TRPV1	CHEBI:18186	7442	Chemical	Gene	residue|amod|START_ENTITY residue|nmod|TM6 TM6|nmod|END_ENTITY	A tyrosine residue in TM6 of the Vanilloid Receptor TRPV1 involved in desensitization and calcium permeability of capsaicin-activated currents .
15084474	0	tyrosine	35,43	TRPV1	14,19	tyrosine	TRPV1	CHEBI:18186	83810(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Modulation Modulation|nmod|END_ENTITY	Modulation of TRPV1 by nonreceptor tyrosine kinase , c-Src_kinase .
12538589	1	tyrosine	116,124	TRPV4	144,149	tyrosine	TRPV4	CHEBI:18186	63873(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress .
20195479	0	tyrosine	2,10	TSH_receptor	26,38	tyrosine	TSH receptor	CHEBI:18186	7253	Chemical	Gene	residue|amod|START_ENTITY residue|nmod|END_ENTITY	A tyrosine residue on the TSH_receptor stabilizes multimer formation .
8780896	0	tyrosine	94,102	TYK2	81,85	tyrosine	TYK2	CHEBI:18186	7297	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Constitutive STAT1 tyrosine phosphorylation in U937 monocytes overexpressing the TYK2 protein tyrosine kinase does not induce gene transcription .
27034374	0	tyrosine	24,32	TYRO3	40,45	tyrosine	TYRO3	D014443	7301	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|ccomp|regulator regulator|nsubj|END_ENTITY	The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity .
1386076	0	tyrosine	52,60	T_cell_receptor_zeta_chain	84,110	tyrosine	T cell receptor zeta chain	CHEBI:18186	919	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Evidence for GTP-binding protein involvement in the tyrosine phosphorylation of the T_cell_receptor_zeta_chain .
10518561	0	tyrosine	79,87	Tec	75,78	tyrosine	Tec	CHEBI:18186	7006	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Molecular cloning of a docking protein , BRDG1 , that acts downstream of the Tec tyrosine kinase .
11328862	0	tyrosine	38,46	Tec	34,37	tyrosine	Tec	CHEBI:18186	7006	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Activation and association of the Tec tyrosine kinase with the human prolactin_receptor : mapping of a Tec/Vav1-receptor binding site .
14993283	1	tyrosine	113,121	Tec	101,104	tyrosine	Txk	CHEBI:18186	7294	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The Tec protein tyrosine kinase is the founding member of a family that includes Btk , Itk , Bmx , and Txk .
15492005	0	tyrosine	80,88	Tec	76,79	tyrosine	Btk	CHEBI:18186	695	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	SHIP family inositol phosphatases interact with and negatively regulate the Tec tyrosine kinase .
15899983	0	tyrosine	72,80	Tec	58,61	tyrosine	Tec	CHEBI:18186	7006	Chemical	Gene	kinases|amod|START_ENTITY family|nmod|kinases family|compound|END_ENTITY	Signaling through CD16b in human neutrophils involves the Tec family of tyrosine kinases .
16677151	0	tyrosine	38,46	Tec	34,37	tyrosine	Tec	CHEBI:18186	84492(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|induction induction|nmod|END_ENTITY	Rapid induction and activation of Tec tyrosine kinase in liver_regeneration .
19688741	0	tyrosine	12,20	Tec	28,31	tyrosine	Tec	CHEBI:18186	21682(Tax:10090)	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|ccomp|regulates regulates|nsubj|END_ENTITY	The protein tyrosine kinase Tec regulates mast cell function .
19883687	0	tyrosine	12,20	Tec	0,3	tyrosine	Tec	CHEBI:18186	7006	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Tec protein tyrosine kinase inhibits CD25 expression in human T-lymphocyte .
20870948	0	tyrosine	12,20	Tec	28,31	tyrosine	Tec	CHEBI:18186	21682(Tax:10090)	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|ccomp|regulates regulates|nsubj|END_ENTITY	The protein tyrosine kinase Tec regulates a CD44highCD62L - Th17 subset .
8877094	0	tyrosine	12,20	Tec	0,3	tyrosine	Tec	CHEBI:18186	21682(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Tec protein tyrosine kinase is involved in the signaling mechanism of granulocyte_colony-stimulating_factor receptor .
9446655	0	tyrosine	45,53	Tec	61,64	tyrosine	Tec	CHEBI:18186	7006	Chemical	Gene	Expression|nmod|START_ENTITY kinase|nsubj|Expression kinase|dobj|END_ENTITY	Expression and activation of the nonreceptor tyrosine kinase Tec in human B cells .
9660965	0	tyrosine	10,18	Tec29	4,9	tyrosine	Tec29	CHEBI:18186	34132(Tax:7227)	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	The Tec29 tyrosine kinase is required during Drosophila embryogenesis and interacts with Src64 in ring canal development .
12036890	0	tyrosine	23,31	Tel-Abl	4,11	tyrosine	Tel-Abl	CHEBI:18186	2120	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The Tel-Abl -LRB- ETV6-Abl -RRB- tyrosine kinase , product of complex -LRB- 9 ; 12 -RRB- translocations in human leukemia , induces distinct myeloproliferative_disease in mice .
17392178	0	tyrosine	36,44	Thrombin	0,8	tyrosine	Thrombin	CHEBI:18186	2147	Chemical	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Thrombin regulates soluble fms-like tyrosine kinase-1 -LRB- sFlt-1 -RRB- expression in first trimester decidua : implications for preeclampsia .
22819145	0	tyrosine	35,43	Thrombin	0,8	tyrosine	Thrombin	CHEBI:18186	2147	Chemical	Gene	kinase|nsubj|START_ENTITY enhances|ccomp|kinase enhances|nsubj|END_ENTITY	Thrombin enhances soluble Fms-like tyrosine kinase 1 expression in trophoblasts ; possible involvement in the pathogenesis of preeclampsia .
2464830	0	tyrosine	44,52	Thrombin	0,8	tyrosine	Thrombin	CHEBI:18186	2147	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|nmod|phosphorylation induces|nsubj|treatment treatment|compound|END_ENTITY	Thrombin treatment induces rapid changes in tyrosine phosphorylation in platelets .
2468666	0	tyrosine	91,99	Thrombin	0,8	tyrosine	Thrombin	CHEBI:18186	2147	Chemical	Gene	induce|nmod|START_ENTITY induce|nsubj|END_ENTITY	Thrombin and collagen induce rapid phosphorylation of a common set of cellular proteins on tyrosine in human platelets .
7679896	0	tyrosine	47,55	Thrombin	0,8	tyrosine	Thrombin	CHEBI:18186	14061(Tax:10090)	Chemical	Gene	Ca|dep|START_ENTITY Ca|compound|END_ENTITY	Thrombin Ca -LRB- 2 + -RRB- - dependently stimulates protein tyrosine phosphorylation in BC3H1 muscle cells .
7689859	0	tyrosine	46,54	Thrombin	0,8	tyrosine	Thrombin	CHEBI:18186	2147	Chemical	Gene	phosphorylation|amod|START_ENTITY causes|dobj|phosphorylation causes|nsubj|activation activation|compound|END_ENTITY	Thrombin activation of human platelets causes tyrosine phosphorylation of PLC-gamma_2 .
7758170	0	tyrosine	79,87	Thrombin	0,8	tyrosine	Thrombin	CHEBI:18186	2147	Chemical	Gene	mechanism|compound|START_ENTITY induces|nmod|mechanism induces|nsubj|END_ENTITY	Thrombin induces the preproendothelin-1 gene in endothelial cells by a protein tyrosine kinase-linked mechanism .
8631786	0	tyrosine	63,71	Thrombin	0,8	tyrosine	Thrombin	CHEBI:18186	2147	Chemical	Gene	phosphorylation|amod|START_ENTITY stimulate|dobj|phosphorylation engagement|xcomp|stimulate engagement|nsubj|activation activation|compound|END_ENTITY	Thrombin receptor activation and integrin engagement stimulate tyrosine phosphorylation of the proto-oncogene product , p95vav , in platelets .
9204916	0	tyrosine	86,94	Thrombin	0,8	tyrosine	Thrombin	CHEBI:18186	2147	Chemical	Gene	kinase|amod|START_ENTITY requiring|dobj|kinase pathway|acl|requiring apoptosis|nmod|pathway induces|dobj|apoptosis induces|nsubj|END_ENTITY	Thrombin induces apoptosis in cultured neurons and astrocytes via a pathway requiring tyrosine kinase and RhoA activities .
9478978	0	tyrosine	53,61	Thrombin	0,8	tyrosine	Thrombin	CHEBI:18186	2147	Chemical	Gene	kinases|amod|START_ENTITY involves|dobj|kinases involves|nsubj|aivation aivation|compound|END_ENTITY	Thrombin aivation of the 9E3/CEF4 chemokine involves tyrosine kinases including c-src and the epidermal_growth_factor_receptor .
9588188	0	tyrosine	32,40	Thrombin	0,8	tyrosine	Thrombin	CHEBI:18186	2147	Chemical	Gene	phosphorylation|amod|START_ENTITY induce|dobj|phosphorylation END_ENTITY|dep|induce	Thrombin per se does not induce tyrosine protein phosphorylation in human platelets as judged by western blotting , while collagen does : the significance of synergistic , autocrine stimulation .
8636428	0	tyrosine	51,59	Thrombin_receptor	0,17	tyrosine	Thrombin receptor	CHEBI:18186	25439(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Thrombin_receptor activation elicits rapid protein tyrosine phosphorylation and stimulation of the raf-1 / MAP kinase pathway preceding delayed mitogenesis in cultured rat aortic smooth muscle cells : evidence for an obligate autocrine mechanism promoting cell proliferation induced by G-protein-coupled receptor agonist .
7544303	0	tyrosine	29,37	Thrombopoietin	0,14	tyrosine	Thrombopoietin	CHEBI:18186	7066	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Thrombopoietin -LRB- TPO -RRB- induces tyrosine phosphorylation and activation of STAT5 and STAT3 .
7589510	0	tyrosine	38,46	Thrombopoietin	0,14	tyrosine	Thrombopoietin	CHEBI:18186	7066	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Thrombopoietin , c-Mpl_ligand , induces tyrosine phosphorylation of Tyk2 , JAK2 , and STAT3 , and enhances agonists-induced aggregation in platelets in vitro .
7780132	0	tyrosine	23,31	Thrombopoietin	0,14	tyrosine	Thrombopoietin	CHEBI:18186	7066	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Thrombopoietin induces tyrosine phosphorylation and activation of the Janus kinase , JAK2 .
8526916	0	tyrosine	23,31	Thrombopoietin	0,14	tyrosine	Thrombopoietin	CHEBI:18186	7066	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Thrombopoietin induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in a human thrombopoietin-dependent cell line .
8555464	0	tyrosine	23,31	Thrombopoietin	0,14	tyrosine	Thrombopoietin	CHEBI:18186	7066	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Thrombopoietin induces tyrosine phosphorylation of Stat3 and Stat5 in human blood platelets .
9108397	0	tyrosine	35,43	Thrombopoietin	0,14	tyrosine	Thrombopoietin	CHEBI:18186	7066	Chemical	Gene	phosphorylation|amod|START_ENTITY induce|dobj|phosphorylation induce|nsubj|END_ENTITY	Thrombopoietin and thrombin induce tyrosine phosphorylation of Vav in human blood platelets .
10233161	0	tyrosine	25,33	Thrombospondin-1	0,16	tyrosine	Thrombospondin-1	CHEBI:18186	7057	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Thrombospondin-1 induces tyrosine phosphorylation of adherens junction proteins and regulates an endothelial paracellular pathway .
10913057	0	tyrosine	44,52	Tie-1	70,75	tyrosine	Tie-1	CHEBI:18186	7075	Chemical	Gene	receptors|compound|START_ENTITY localisation|nmod|receptors localisation|amod|END_ENTITY	Immunohistochemical localisation of protein tyrosine kinase receptors Tie-1 and Tie-2 in synovial tissue of rheumatoid_arthritis : correlation with angiogenesis and synovial proliferation .
11261813	0	tyrosine	14,22	Tie-1	40,45	tyrosine	Tie-1	CHEBI:18186	7075	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Expression of tyrosine kinase receptors Tie-1 and Tie-2 in giant_cell_tumor_of_the_tendon_sheath : a possible role in synovial proliferation .
11501841	0	tyrosine	6,14	Tie-1	0,5	tyrosine	Tie-1	CHEBI:18186	7075	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Tie-1 tyrosine kinase is an independent prognostic indicator for invasive breast_cancer .
12853700	0	tyrosine	31,39	Tie-1	47,52	tyrosine	Tie-1	CHEBI:18186	7075	Chemical	Gene	Overexpression|nmod|START_ENTITY kinase|nsubj|Overexpression kinase|dobj|domain domain|compound|END_ENTITY	Overexpression of the receptor tyrosine kinase Tie-1 intracellular domain in breast_cancer .
18448073	0	tyrosine	9,17	Tie-1	25,30	tyrosine	Tie-1	CHEBI:18186	7075	Chemical	Gene	overexpression|amod|START_ENTITY overexpression|compound|END_ENTITY	Receptor tyrosine kinase Tie-1 overexpression in endothelial cells upregulates adhesion molecules .
24603462	0	tyrosine	51,59	Tie-1	68,73	tyrosine	Tie-1	CHEBI:18186	7075	Chemical	Gene	levels|nmod|START_ENTITY balance|nmod|levels kinases|nsubj|balance kinases|dobj|END_ENTITY	Disturbed balance between serum levels of receptor tyrosine kinases Tie-1 , Tie-2 and angiopoietins in systemic_sclerosis .
7596437	0	tyrosine	31,39	Tie-1	48,53	tyrosine	Tie-1	CHEBI:18186	21846(Tax:10090)	Chemical	Gene	roles|nmod|START_ENTITY kinases|nsubj|roles kinases|dobj|END_ENTITY	Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation .
8415706	0	tyrosine	58,66	Tie-1	0,5	tyrosine	Tie-1	CHEBI:18186	21846(Tax:10090)	Chemical	Gene	genes|compound|START_ENTITY class|nmod|genes define|dobj|class END_ENTITY|dep|define	Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic_vascular_system .
22454630	0	tyrosine	22,30	Tie-2	85,90	tyrosine	Tie-2	CHEBI:18186	21687(Tax:10090)	Chemical	Gene	phosphatase|compound|START_ENTITY Inhibition|nmod|phosphatase improves|nsubj|Inhibition END_ENTITY|dep|improves	Inhibition of protein tyrosine phosphatase improves angiogenesis via enhancing Ang-1 / Tie-2 signaling in diabetes .
9926914	0	tyrosine	21,29	Tie-2	82,87	tyrosine	Tie-2	CHEBI:18186	7010	Chemical	Gene	kinases|compound|START_ENTITY activate|nsubj|kinases activate|parataxis|signals signals|nsubj|END_ENTITY	Endothelial receptor tyrosine kinases activate the STAT signaling pathway : mutant Tie-2 causing venous_malformations signals a distinct STAT activation response .
17786322	0	tyrosine	13,21	Tie1	29,33	tyrosine	Tie1	CHEBI:18186	7075	Chemical	Gene	START_ENTITY|ccomp|expressed expressed|nsubjpass|END_ENTITY	The receptor tyrosine kinase Tie1 is expressed and activated in epithelial_tumour cell lines .
18848573	0	tyrosine	22,30	Tie1	39,43	tyrosine	Tie1	CHEBI:18186	7075	Chemical	Gene	Roles|nmod|START_ENTITY kinases|nsubj|Roles kinases|dobj|END_ENTITY	Roles of the receptor tyrosine kinases Tie1 and Tie2 in mediating the effects of angiopoietin-1 on endothelial permeability and apoptosis .
19449109	2	tyrosine	320,328	Tie1	347,351	tyrosine	Tie2	CHEBI:18186	7010	Chemical	Gene	receptors|amod|START_ENTITY receptors|dep|END_ENTITY	The Angiopoietin family includes four ligands -LRB- Angiopoietin-1 , Angiopoietin-2 and Angiopoietin-3 / 4 -RRB- and two corresponding tyrosine kinase receptors -LRB- Tie1 and Tie2 -RRB- .
24152847	4	tyrosine	445,453	Tie1	472,476	tyrosine	Tie2	CHEBI:18186	7010	Chemical	Gene	START_ENTITY|dobj|receptors receptors|dep|END_ENTITY	The angiopoietin receptor system consists of two type I tyrosine kinase receptors -LRB- Tie1 and Tie2 -RRB- .
11513602	0	tyrosine	55,63	Tie2	112,116	tyrosine	Tie2	CHEBI:18186	7010	Chemical	Gene	catalysis|compound|START_ENTITY autophosphorylation|nmod|catalysis effects|nmod|autophosphorylation effects|dep|characterization characterization|nmod|END_ENTITY	Mechanistic effects of autophosphorylation on receptor tyrosine kinase catalysis : enzymatic characterization of Tie2 and phospho-Tie2 .
12609966	0	tyrosine	33,41	Tie2	49,53	tyrosine	Tie2	CHEBI:18186	7010	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|dobj|interacts interacts|amod|END_ENTITY	The antiinflammatory endothelial tyrosine kinase Tie2 interacts with a novel nuclear factor-kappaB inhibitor ABIN-2 .
13130465	0	tyrosine	14,22	Tie2	0,4	tyrosine	Tie2	CHEBI:18186	7010	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Tie2 receptor tyrosine kinase , a major mediator of tumor_necrosis_factor_alpha-induced angiogenesis in rheumatoid_arthritis .
14665640	0	tyrosine	27,35	Tie2	43,47	tyrosine	Tie2	CHEBI:18186	7010	Chemical	Gene	START_ENTITY|dobj|receptor receptor|amod|END_ENTITY	Adaptor ShcA protein binds tyrosine kinase Tie2 receptor and regulates migration and sprouting but not survival of endothelial cells .
15851516	0	tyrosine	70,78	Tie2	119,123	tyrosine	Tie2	CHEBI:18186	7010	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|nmod|END_ENTITY	Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2 .
15899871	0	tyrosine	29,37	Tie2	49,53	tyrosine	Tie2	CHEBI:18186	21687(Tax:10090)	Chemical	Gene	residue|compound|START_ENTITY role|nmod|residue role|nmod|END_ENTITY	Selective role of a distinct tyrosine residue on Tie2 in heart development and early hematopoiesis .
15985432	8	tyrosine	944,952	Tie2	977,981	tyrosine	Tie2	CHEBI:18186	7010	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Flow significantly increased tyrosine phosphorylation of both Tie2 and PECAM1 and their association with SHP2 .
16157706	0	tyrosine	57,65	Tie2	52,56	tyrosine	Tie2	CHEBI:18186	7010	Chemical	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Stable interaction between alpha5beta1 integrin and Tie2 tyrosine kinase receptor regulates endothelial cell response to Ang-1 .
17189382	0	tyrosine	27,35	Tie2	43,47	tyrosine	Tie2	CHEBI:18186	7010	Chemical	Gene	START_ENTITY|ccomp|associated associated|nsubjpass|END_ENTITY	Expression of the receptor tyrosine kinase Tie2 in neoplastic glial cells is associated with integrin_beta1-dependent adhesion to the extracellular matrix .
19615361	0	tyrosine	59,67	Tie2	45,49	tyrosine	Tie2	CHEBI:18186	7010	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Lipid rafts serve as signaling platforms for Tie2 receptor tyrosine kinase in vascular endothelial cells .
19922791	0	tyrosine	50,58	Tie2	66,70	tyrosine	Tie2	CHEBI:18186	7010	Chemical	Gene	kinase|compound|START_ENTITY _|nmod|kinase END_ENTITY|amod|_	Effects of angiopoietins-1_and _ -2 on the receptor tyrosine kinase Tie2 are differentially regulated at the endothelial cell surface .
20018779	0	tyrosine	78,86	Tie2	113,117	tyrosine	Tie2	CHEBI:18186	21687(Tax:10090)	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|acl|regulating regulating|dobj|pathway pathway|amod|END_ENTITY	Embryonic stem cell tumor model reveals role of vascular endothelial receptor tyrosine phosphatase in regulating Tie2 pathway in tumor angiogenesis .
20054548	0	tyrosine	37,45	Tie2	53,57	tyrosine	Tie2	CHEBI:18186	7010	Chemical	Gene	Shedding|nmod|START_ENTITY kinase|nsubj|Shedding kinase|dobj|correlates correlates|amod|END_ENTITY	Shedding of the endothelial receptor tyrosine kinase Tie2 correlates with leukemic_blast_burden and outcome after allogeneic hematopoietic stem cell transplantation for AML .
24478383	0	tyrosine	22,30	Tie2	0,4	tyrosine	Tie2	CHEBI:18186	7010	Chemical	Gene	START_ENTITY|nsubj|receptor receptor|amod|END_ENTITY	Tie2 and Eph receptor tyrosine kinase activation and signaling .
23924390	0	tyrosine	14,22	Tks5	90,94	tyrosine	Tks5	CHEBI:18186	9644	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	EGF regulates tyrosine phosphorylation and membrane-translocation of the scaffold protein Tks5 .
17178723	0	tyrosine	4,12	Toll-like_receptor_3	25,45	tyrosine	Toll-like receptor 3	CHEBI:18186	7098	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Two tyrosine residues of Toll-like_receptor_3 trigger different steps of NF-kappa_B activation .
16140274	0	tyrosine	82,90	Toll-like_receptor_4	156,176	tyrosine	Toll-like receptor 4	CHEBI:18186	7099	Chemical	Gene	kinases|compound|START_ENTITY expression|nmod|kinases regulation|nmod|expression mediated|nsubj|regulation mediated|nmod|MyD88-independent MyD88-independent|acl|signaling signaling|dobj|pathways pathways|nmod|END_ENTITY	The regulation of the expression of inducible_nitric_oxide_synthase by Src-family tyrosine kinases mediated through MyD88-independent signaling pathways of Toll-like_receptor_4 .
17977838	0	tyrosine	60,68	Toll-like_receptor_4	90,110	tyrosine	Toll-like receptor 4	CHEBI:18186	7099	Chemical	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Novel roles in human MD-2_of_phenylalanines_121 and 126 and tyrosine 131 in activation of Toll-like_receptor_4 by endotoxin .
23908181	0	tyrosine	103,111	Toll-like_receptor_4	0,20	tyrosine	Toll-like receptor 4	CHEBI:18186	21898(Tax:10090)	Chemical	Gene	retinal_ischemia|parataxis|START_ENTITY retinal_ischemia|amod|END_ENTITY	Toll-like_receptor_4 mediates retinal_ischemia / reperfusion injury through nuclear factor-kB and spleen tyrosine kinase activation .
8384582	0	tyrosine	18,26	Torso	0,5	tyrosine	Torso	CHEBI:18186	35717(Tax:7227)	Chemical	Gene	kinase|compound|START_ENTITY END_ENTITY|appos|kinase	Torso , a receptor tyrosine kinase required for embryonic pattern formation , shares substrates with the sevenless and EGF-R pathways in Drosophila .
7980404	0	tyrosine	43,51	Transforming_growth_factor-alpha	0,32	tyrosine	Transforming growth factor-alpha	CHEBI:18186	24827(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|increases increases|amod|END_ENTITY	Transforming_growth_factor-alpha increases tyrosine phosphorylation of microtubule-associated protein kinase in a small intestinal crypt cell line -LRB- IEC-6 -RRB- .
10473107	0	tyrosine	8,16	Trk	4,7	tyrosine	Trk	CHEBI:18186	4914	Chemical	Gene	CEP-701|amod|START_ENTITY CEP-701|compound|END_ENTITY	The Trk tyrosine kinase inhibitor CEP-701 -LRB- KT-5555 -RRB- exhibits significant antitumor efficacy in preclinical xenograft models of human pancreatic_ductal_adenocarcinoma .
11295066	0	tyrosine	18,26	Trk	14,17	tyrosine	Trk	CHEBI:18186	4914	Chemical	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Expression of Trk tyrosine kinase receptor is a biologic marker for cell proliferation and perineural invasion of human pancreatic_ductal_adenocarcinoma .
11431098	0	tyrosine	13,21	Trk	0,3	tyrosine	Trk	CHEBI:18186	4914	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Trk receptor tyrosine kinases : a bridge between cancer and neural development .
12006576	0	tyrosine	55,63	Trk	32,35	tyrosine	Trk	CHEBI:18186	4914	Chemical	Gene	kinases|compound|START_ENTITY family|nmod|kinases family|compound|END_ENTITY	ShcB and ShcC activation by the Trk family of receptor tyrosine kinases .
12929129	1	tyrosine	216,224	Trk	203,206	tyrosine	p75	CHEBI:18186	24596(Tax:10116)	Chemical	Gene	family|compound|START_ENTITY family|compound|END_ENTITY	Neurotrophins interact with two distinct classes of cell-surface receptors , the Trk receptor tyrosine kinase family and the common neurotrophin receptor p75 -LRB- NTR -RRB- .
1339678	0	tyrosine	18,26	Trk	4,7	tyrosine	Trk	CHEBI:18186	4914	Chemical	Gene	kinases|amod|START_ENTITY family|nmod|kinases family|compound|END_ENTITY	The Trk family of tyrosine kinases : receptors for NGF-related neurotrophins .
16837782	0	tyrosine	86,94	Trk	75,78	tyrosine	Trk	CHEBI:18186	4914	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Cyclic-AMP response element-based signaling assays for characterization of Trk family tyrosine kinases modulators .
16912468	0	tyrosine	70,78	Trk	42,45	tyrosine	Trk	CHEBI:18186	4914	Chemical	Gene	superfamily|nmod|START_ENTITY superfamily|compound|END_ENTITY	Tracing the evolution and function of the Trk superfamily of receptor tyrosine kinases .
16971381	0	tyrosine	52,60	Trk	48,51	tyrosine	Trk	CHEBI:18186	59109(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Dependence Dependence|nmod|activation activation|nmod|END_ENTITY	Dependence of neurotrophic factor activation of Trk tyrosine kinase receptors on cellular sialidase .
19621257	0	tyrosine	119,127	Trk	115,118	tyrosine	Trk	CHEBI:18186	59109(Tax:10116)	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Protective and antioxidative effects of GM1 ganglioside in PC12 cells exposed to hydrogen_peroxide are mediated by Trk tyrosine kinase .
20161825	0	tyrosine	77,85	Trk	64,67	tyrosine	Trk	CHEBI:18186	4914	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Cellular assays for high-throughput screening for modulators of Trk receptor tyrosine kinases .
22982231	0	tyrosine	62,70	Trk	39,42	tyrosine	Trk	CHEBI:18186	4914	Chemical	Gene	family|nmod|START_ENTITY family|compound|END_ENTITY	Novel small molecule activators of the Trk family of receptor tyrosine kinases .
25216715	0	tyrosine	59,67	Trk	55,58	tyrosine	Trk	CHEBI:18186	59109(Tax:10116)	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	GM1 ganglioside activates ERK1/2 and Akt downstream of Trk tyrosine kinase and protects PC12 cells against hydrogen_peroxide toxicity .
26574547	0	tyrosine	101,109	Trk	33,36	tyrosine	Trk	D014443	4914	Chemical	Gene	phosphatase|compound|START_ENTITY phosphorylation|nmod|phosphatase induces|dobj|phosphorylation pathway|acl:relcl|induces signaling|dobj|pathway END_ENTITY|acl|signaling	Zn2 + - dependent activation of the Trk signaling pathway induces phosphorylation of the brain-enriched tyrosine phosphatase STEP : molecular basis for Zn2 + - induced ERK MAPK activation .
7902578	0	tyrosine	67,75	Trk	83,86	tyrosine	Trk	CHEBI:18186	18211(Tax:10090)	Chemical	Gene	Expression|nmod|START_ENTITY kinase|nsubj|Expression kinase|dobj|END_ENTITY	Expression of nerve_growth_factor and nerve_growth_factor receptor tyrosine kinase Trk in activated CD4-positive T-cell clones .
8508763	0	tyrosine	38,46	Trk	34,37	tyrosine	Trk	CHEBI:18186	4914	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|binding binding|nmod|END_ENTITY	An extended surface of binding to Trk tyrosine kinase receptors in NGF and BDNF allows the engineering of a multifunctional pan-neurotrophin .
8635559	0	tyrosine	79,87	Trk	75,78	tyrosine	NGF	CHEBI:18186	310738(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|compound|END_ENTITY	Intraparenchymal NGF injections in adult and aged rats induce long-lasting Trk tyrosine phosphorylation .
9015309	9	tyrosine	1346,1354	Trk	1378,1381	tyrosine	trk	CHEBI:18186	59109(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|protein protein|compound|END_ENTITY	Furthermore , both propeptides induced rapid tyrosine phosphorylation of the Trk protein in both prostatic_adenocarcinoma cells and PC12 cells , thus implicating trk in their mechanism of action .
9092490	0	tyrosine	67,75	Trk	95,98	tyrosine	Trk	CHEBI:18186	59109(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Overexpression of N-acetylglucosaminyltransferase_III disrupts the tyrosine phosphorylation of Trk with resultant signaling dysfunction in PC12 cells treated with nerve growth factor .
8577813	0	tyrosine	14,22	Trk-B	47,52	tyrosine	Trk-B	CHEBI:18186	25054(Tax:10116)	Chemical	Gene	protein|amod|START_ENTITY Regulation|nmod|protein kinase|nsubj|Regulation kinase|dobj|END_ENTITY	Regulation of tyrosine protein kinase receptor Trk-B and motor function in rats following cardiac_arrest .
10708759	0	tyrosine	76,84	TrkA	52,56	tyrosine	TrkA	CHEBI:18186	4914	Chemical	Gene	kinase|compound|START_ENTITY interaction|nmod|kinase interaction|appos|END_ENTITY	Direct interaction of nerve_growth_factor_receptor , TrkA , with non-receptor tyrosine kinase , c-Abl , through the activation loop .
10748052	0	tyrosine	122,130	TrkA	139,143	tyrosine	TrkA	CHEBI:18186	59109(Tax:10116)	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	Direct binding of the signaling adapter protein Grb2 to the activation loop tyrosines on the nerve growth factor receptor tyrosine kinase , TrkA .
10751151	0	tyrosine	107,115	TrkA	14,18	tyrosine	TrkA	CHEBI:18186	18211(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY promotes|nmod|phosphorylation promotes|nsubj|Activation Activation|nmod|kinase kinase|compound|END_ENTITY	Activation of TrkA tyrosine kinase in embryonal_carcinoma cells promotes cell compaction , independently of tyrosine phosphorylation of catenins .
10751151	0	tyrosine	19,27	TrkA	14,18	tyrosine	TrkA	CHEBI:18186	18211(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Activation of TrkA tyrosine kinase in embryonal_carcinoma cells promotes cell compaction , independently of tyrosine phosphorylation of catenins .
12150951	0	tyrosine	64,72	TrkA	56,60	tyrosine	TrkA	CHEBI:18186	4914	Chemical	Gene	phosphorylation|amod|START_ENTITY END_ENTITY|nmod|phosphorylation	Evidence for a role of the nerve growth factor receptor TrkA in tyrosine phosphorylation and processing of beta-APP .
12944916	0	tyrosine	47,55	TrkA	33,37	tyrosine	TrkA	CHEBI:18186	4914	Chemical	Gene	START_ENTITY|nsubj|cross-regulation cross-regulation|nmod|END_ENTITY	Differential cross-regulation of TrkA and TrkC tyrosine kinase receptors with p75 .
15240558	0	tyrosine	41,49	TrkA	36,40	tyrosine	TrkA	CHEBI:18186	59109(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|targets targets|appos|END_ENTITY	Trypanosome trans-sialidase targets TrkA tyrosine kinase receptor and induces receptor internalization and activation .
15513915	0	tyrosine	23,31	TrkA	150,154	tyrosine	TrkA	CHEBI:18186	59109(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY dependent|nsubj|phosphorylation dependent|nmod|domain domain|nmod|END_ENTITY	Neurotrophin-dependent tyrosine phosphorylation of Ras_guanine-releasing_factor_1 and associated neurite outgrowth is dependent on the HIKE domain of TrkA .
16428543	0	tyrosine	91,99	TrkA	119,123	tyrosine	TrkA	CHEBI:18186	59109(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Local anesthetics suppress nerve growth factor-mediated neurite outgrowth by inhibition of tyrosine kinase activity of TrkA .
18410251	0	tyrosine	28,36	TrkA	45,49	tyrosine	TrkA	CHEBI:18186	4914	Chemical	Gene	Auto-antibodies|nmod|START_ENTITY kinases|nsubj|Auto-antibodies kinases|dobj|END_ENTITY	Auto-antibodies to receptor tyrosine kinases TrkA , TrkB and TrkC in patients with chronic_Chagas ' _ disease .
18477627	0	tyrosine	8,16	TrkA	62,66	tyrosine	TrkA	CHEBI:18186	18211(Tax:10090)	Chemical	Gene	Z|compound|START_ENTITY dephosphorylates|nsubj|Z dephosphorylates|dobj|receptors receptors|compound|END_ENTITY	Protein tyrosine phosphatase receptor type Z dephosphorylates TrkA receptors and attenuates NGF-dependent neurite outgrowth of PC12 cells .
19755102	0	tyrosine	51,59	TrkA	37,41	tyrosine	TrkA	CHEBI:18186	4914	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	CCM2 mediates death signaling by the TrkA receptor tyrosine kinase .
20600627	0	tyrosine	29,37	TrkA	24,28	tyrosine	TrkA	CHEBI:18186	4914	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	A monovalent agonist of TrkA tyrosine kinase receptors can be converted into a bivalent antagonist .
23266087	0	tyrosine	9,17	TrkA	57,61	tyrosine	TrkA	CHEBI:18186	4914	Chemical	Gene	kinase|compound|START_ENTITY kinase|dep|responses responses|compound|END_ENTITY	Receptor tyrosine kinase signaling mechanisms : Devolving TrkA responses with phosphoproteomics .
23749991	1	tyrosine	140,148	TrkA	94,98	tyrosine	TrkA	CHEBI:18186	59109(Tax:10116)	Chemical	Gene	kinase|compound|START_ENTITY kinase|nsubj|END_ENTITY	TrkA is a cell surface transmembrane receptor tyrosine kinase for nerve_growth_factor -LRB- NGF -RRB- .
7582085	0	tyrosine	5,13	TrkA	0,4	tyrosine	TrkA	CHEBI:18186	59109(Tax:10116)	Chemical	Gene	residues|compound|START_ENTITY residues|compound|END_ENTITY	TrkA tyrosine residues involved in NGF-induced neurite outgrowth of PC12 cells .
8737668	0	tyrosine	51,59	TrkA	68,72	tyrosine	TrkA	CHEBI:18186	59109(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|mRNAs mRNAs|appos|END_ENTITY	Presence and localization of neurotrophin receptor tyrosine kinase -LRB- TrkA , TrkB , TrkC -RRB- mRNAs in visceral afferent neurons of the nodose and petrosal ganglia .
9275225	0	tyrosine	76,84	TrkA	93,97	tyrosine	TrkA	CHEBI:18186	59109(Tax:10116)	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	A signaling organelle containing the nerve growth factor-activated receptor tyrosine kinase , TrkA .
10533983	0	tyrosine	18,26	TrkB	4,8	tyrosine	TrkB	CHEBI:18186	18212(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The TrkB receptor tyrosine kinase regulates cellular proliferation via signal transduction pathways involving SHC , PLCgamma , and CBL .
10716894	0	tyrosine	51,59	TrkB	68,72	tyrosine	TrkB	CHEBI:18186	396157(Tax:9031)	Chemical	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Role for basic_fibroblast_growth_factor -LRB- FGF-2 -RRB- in tyrosine kinase -LRB- TrkB -RRB- expression in the early development and innervation of the auditory receptor : in vitro and in situ studies .
10825163	0	tyrosine	17,25	TrkB	12,16	tyrosine	TrkB	CHEBI:18186	25054(Tax:10116)	Chemical	Gene	autophosphorylation|compound|START_ENTITY autophosphorylation|compound|END_ENTITY	p75 reduces TrkB tyrosine autophosphorylation in response to brain-derived_neurotrophic_factor and neurotrophin_4 / 5 .
10833508	0	tyrosine	107,115	TrkB	0,4	tyrosine	TrkB	CHEBI:18186	4915	Chemical	Gene	phosphorylation|amod|START_ENTITY inward|nmod|phosphorylation inhibits|ccomp|inward inhibits|nsubj|activation activation|amod|END_ENTITY	TrkB activation by brain-derived_neurotrophic_factor inhibits the G protein-gated inward rectifier Kir3 by tyrosine phosphorylation of the channel .
12074588	0	tyrosine	97,105	TrkB	92,96	tyrosine	TrkB	CHEBI:18186	4915	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Brain-derived_neurotrophic_factor promotes interaction of the Nck2 adaptor protein with the TrkB tyrosine kinase receptor .
12810600	6	tyrosine	1548,1556	TrkB	1835,1839	tyrosine	GDNF	CHEBI:18186	25453(Tax:10116)	Chemical	Gene	cells|amod|START_ENTITY number|nmod|cells coeruleus|nsubj|number increased|ccomp|coeruleus suggest|advcl|increased suggest|ccomp|involve involve|nsubj|effect effect|nmod|ligands ligands|compound|END_ENTITY	Because TrkB ligands increased the number of tyrosine hydroxylase-positive cells expressing Phox2a , a paired homeodomain protein required for the development of locus coeruleus noradrenergic neurons , but did not affect the number of Phox2a-positive tyrosine hydroxylase-negative cells , our results suggest that the second effect of TrkB ligands may involve promoting or inducing a noradrenergic phenotype .
14581459	0	tyrosine	28,36	TrkB	14,18	tyrosine	TrkB	CHEBI:18186	4915	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|receptor receptor|compound|END_ENTITY	Regulation of TrkB receptor tyrosine kinase and its internalization by neuronal activity and Ca2 + influx .
14632312	0	tyrosine	39,47	TrkB	83,87	tyrosine	TrkB	CHEBI:18186	4915	Chemical	Gene	residues|compound|START_ENTITY Association|nmod|residues Association|nmod|END_ENTITY	Association of SH2-B to phosphorylated tyrosine residues in the activation loop of TrkB .
17475794	0	tyrosine	4,12	TrkB	55,59	tyrosine	TrkB	CHEBI:18186	18212(Tax:10090)	Chemical	Gene	Fyn|amod|START_ENTITY determines|nsubj|Fyn determines|dobj|localization localization|nmod|receptors receptors|compound|END_ENTITY	The tyrosine kinase Fyn determines the localization of TrkB receptors in lipid rafts .
18286198	0	tyrosine	34,42	TrkB	21,25	tyrosine	TrkB	CHEBI:18186	4915	Chemical	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	A cross-talk between TrkB and Ret tyrosine kinases receptors mediates neuroblastoma cells differentiation .
18678285	0	tyrosine	40,48	TrkB	26,30	tyrosine	TrkB	CHEBI:18186	4915	Chemical	Gene	alters|compound|START_ENTITY alters|compound|END_ENTITY	Expression of the TrkA or TrkB receptor tyrosine kinase alters the double-strand break -LRB- DSB -RRB- repair capacity of SY5Y neuroblastoma cells .
20605779	0	tyrosine	24,32	TrkB	40,44	tyrosine	TrkB	CHEBI:18186	4915	Chemical	Gene	Binding|nmod|START_ENTITY kinase|nsubj|Binding kinase|ccomp|regulates regulates|nsubj|END_ENTITY	Binding of the receptor tyrosine kinase TrkB to the neural_cell_adhesion_molecule -LRB- NCAM -RRB- regulates phosphorylation of NCAM and NCAM-dependent neurite outgrowth .
23785422	0	tyrosine	125,133	TrkB	120,124	tyrosine	TrkB	CHEBI:18186	4915	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|compound|END_ENTITY	A loss-of-function screen for phosphatases that regulate neurite outgrowth identifies PTPN12 as a negative regulator of TrkB tyrosine phosphorylation .
8439408	0	tyrosine	41,49	TrkB	28,32	tyrosine	TrkB	CHEBI:18186	4915	Chemical	Gene	START_ENTITY|nsubj|production production|nmod|protein protein|compound|END_ENTITY	Increased production of the TrkB protein tyrosine kinase receptor after brain insults .
8737668	0	tyrosine	51,59	TrkB	74,78	tyrosine	TrkB	CHEBI:18186	25054(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|mRNAs mRNAs|appos|TrkA TrkA|dep|END_ENTITY	Presence and localization of neurotrophin receptor tyrosine kinase -LRB- TrkA , TrkB , TrkC -RRB- mRNAs in visceral afferent neurons of the nodose and petrosal ganglia .
9054577	0	tyrosine	49,57	TrkB	44,48	tyrosine	TrkB	CHEBI:18186	4915	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Sequential cis/trans autophosphorylation in TrkB tyrosine kinase .
9648856	0	tyrosine	30,38	TrkB	55,59	tyrosine	TrkB	CHEBI:18186	25054(Tax:10116)	Chemical	Gene	Association|nmod|START_ENTITY kinase|nsubj|Association kinase|dobj|Fyn Fyn|nmod|END_ENTITY	Association of the Src family tyrosine kinase Fyn with TrkB .
8737668	0	tyrosine	51,59	TrkC	80,84	tyrosine	TrkC	CHEBI:18186	29613(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|mRNAs mRNAs|appos|TrkA TrkA|dep|END_ENTITY	Presence and localization of neurotrophin receptor tyrosine kinase -LRB- TrkA , TrkB , TrkC -RRB- mRNAs in visceral afferent neurons of the nodose and petrosal ganglia .
12115676	0	tyrosine	17,25	Trka	34,38	tyrosine	Trka	CHEBI:18186	59109(Tax:10116)	Chemical	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	Up-regulation of tyrosine kinase -LRB- Trka , Trkb -RRB- receptor expression and phosphorylation in lumbosacral dorsal root ganglia after chronic spinal cord -LRB- T8-T10 -RRB- injury .
12115676	0	tyrosine	17,25	Trkb	40,44	tyrosine	Trkb	CHEBI:18186	25054(Tax:10116)	Chemical	Gene	kinase|amod|START_ENTITY kinase|appos|Trka Trka|dep|END_ENTITY	Up-regulation of tyrosine kinase -LRB- Trka , Trkb -RRB- receptor expression and phosphorylation in lumbosacral dorsal root ganglia after chronic spinal cord -LRB- T8-T10 -RRB- injury .
8421704	0	tyrosine	53,61	Tsk	75,78	tyrosine	Tsk	CHEBI:18186	16428(Tax:10090)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Developmental regulation of a murine T-cell-specific tyrosine kinase gene , Tsk .
1378752	0	tyrosine	32,40	Tumor_necrosis_factor	0,21	tyrosine	Tumor necrosis factor	CHEBI:18186	7124	Chemical	Gene	phosphorylation|amod|START_ENTITY regulates|dobj|phosphorylation regulates|nsubj|END_ENTITY	Tumor_necrosis_factor regulates tyrosine phosphorylation on epidermal growth factor receptors in A431 carcinoma cells : evidence for a distinct mechanism .
10523612	0	tyrosine	19,27	Txk	0,3	tyrosine	Txk	CHEBI:18186	7294	Chemical	Gene	kinase|compound|START_ENTITY END_ENTITY|appos|kinase	Txk , a nonreceptor tyrosine kinase of the Tec family , is expressed in T helper type 1 cells and regulates interferon gamma production in human T lymphocytes .
10562318	0	tyrosine	26,34	Txk	42,45	tyrosine	Txk	CHEBI:18186	22165(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY kinase|nsubj|role kinase|dobj|END_ENTITY	A role for the Tec family tyrosine kinase Txk in T cell activation and thymocyte selection .
7629131	0	tyrosine	40,48	Tyk-2	56,61	tyrosine	Tyk-2	CHEBI:18186	7297	Chemical	Gene	Association|nmod|START_ENTITY kinase|nsubj|Association kinase|dobj|END_ENTITY	Association of the interferon-dependent tyrosine kinase Tyk-2 with the hematopoietic_cell_phosphatase .
9038355	0	tyrosine	73,81	Tyk-2	59,64	tyrosine	Tyk-2	CHEBI:18186	7297	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The vav proto-oncogene product -LRB- p95vav -RRB- interacts with the Tyk-2 protein tyrosine kinase .
15262176	0	tyrosine	124,132	Tyk2	141,145	tyrosine	Tyk2	D014443	7297	Chemical	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	RRR-alpha-tocopherol decreases the expression of the major scavenger receptor , CD36 , in human macrophages via inhibition of tyrosine kinase -LRB- Tyk2 -RRB- .
16982690	0	tyrosine	5,13	Tyk2	0,4	tyrosine	Tyk2	CHEBI:18186	54721(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY expression|nummod|END_ENTITY	Tyk2 tyrosine kinase expression is required for the maintenance of mitochondrial respiration in primary pro-B lymphocytes .
7589510	0	tyrosine	38,46	Tyk2	66,70	tyrosine	Tyk2	CHEBI:18186	7297	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Thrombopoietin , c-Mpl_ligand , induces tyrosine phosphorylation of Tyk2 , JAK2 , and STAT3 , and enhances agonists-induced aggregation in platelets in vitro .
16365397	0	tyrosine	120,128	Tyro3	105,110	tyrosine	Tyro3	CHEBI:18186	22174(Tax:10090)	Chemical	Gene	kinases|compound|START_ENTITY kinases|amod|END_ENTITY	Heterogeneous nuclear ribonucleoprotein P2 is an autoantibody target in mice deficient for Mer , Axl , and Tyro3 receptor tyrosine kinases .
16751775	0	tyrosine	61,69	Tyro3	46,51	tyrosine	Tyro3	CHEBI:18186	7301	Chemical	Gene	kinases|compound|START_ENTITY kinases|amod|END_ENTITY	Natural killer cell differentiation driven by Tyro3 receptor tyrosine kinases .
23203851	0	tyrosine	44,52	Tyro3	24,29	tyrosine	Tyro3	CHEBI:18186	22174(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|efficacy efficacy|nmod|END_ENTITY	Therapeutic efficacy of Tyro3 , Axl , and Mer tyrosine kinase agonists in collagen-induced_arthritis .
23689306	0	tyrosine	90,98	Tyro3	62,67	tyrosine	Tyro3	CHEBI:18186	22174(Tax:10090)	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Breakdown of immune homeostasis in the testis of mice lacking Tyro3 , Axl and Mer receptor tyrosine kinases .
25815442	0	tyrosine	33,41	Tyro3	18,23	tyrosine	Tyro3	CHEBI:18186	7301	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Overexpression of Tyro3 receptor tyrosine kinase leads to the acquisition of taxol resistance in ovarian_cancer cells .
18159085	0	tyrosine	29,37	Tyro_3	13,19	tyrosine	Tyro 3	CHEBI:18186	7301	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Gas6 and the Tyro_3 receptor tyrosine kinase subfamily regulate the phagocytic function of Sertoli cells .
9617898	0	tyrosine	16,24	Tyro_3	0,6	tyrosine	Tyro 3	CHEBI:18186	100342822(Tax:9986)	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Tyro_3 receptor tyrosine kinase and its ligand , Gas6 , stimulate the function of osteoclasts .
1812074	0	tyrosine	71,79	Tyrosinase	0,10	tyrosine	Tyrosinase	CHEBI:18186	22173(Tax:10090)	Chemical	Gene	phenyl_alanine|amod|START_ENTITY concentrations|nmod|phenyl_alanine lag|nmod|concentrations lag|nsubj|exhibits exhibits|amod|END_ENTITY	Tyrosinase exhibits lag at pH 6.8 under steady state concentrations of tyrosine and 3,4-dihydroxy _ phenyl_alanine in melanoma tissue .
15911134	0	tyrosine	21,29	Urocortin	0,9	tyrosine	Urocortin	CHEBI:18186	29151(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|stimulates stimulates|compound|END_ENTITY	Urocortin stimulates tyrosine hydroxylase activity via the cAMP/protein kinase a pathway in rat Pheochromocytoma PC12 cells .
10444524	0	tyrosine	45,53	Urokinase-type_plasminogen_activator	0,36	tyrosine	Urokinase-type plasminogen activator	CHEBI:18186	5328	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Urokinase-type_plasminogen_activator induces tyrosine phosphorylation of a 78-kDa protein in H-157 cells .
11959824	0	tyrosine	87,95	VAB-1	68,73	tyrosine	VAB-1	CHEBI:18186	173794(Tax:6239)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The C. _ elegans LAR-like receptor tyrosine phosphatase PTP-3 and the VAB-1 Eph receptor tyrosine kinase have partly redundant functions in morphogenesis .
9506518	0	tyrosine	23,31	VAB-1	4,9	tyrosine	VAB-1	CHEBI:18186	173794(Tax:6239)	Chemical	Gene	START_ENTITY|nsubj|receptor receptor|compound|END_ENTITY	The VAB-1 Eph receptor tyrosine kinase functions in neural and epithelial morphogenesis in C. _ elegans .
22014333	0	tyrosine	14,22	VASP	42,46	tyrosine	VASP	D014443	7408	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Abl-1-bridged tyrosine phosphorylation of VASP by Abelson kinase impairs association of VASP to focal adhesions and regulates leukaemic cell adhesion .
17360632	0	tyrosine	21,29	VE-PTP	43,49	tyrosine	VE-PTP	CHEBI:18186	19263(Tax:10090)	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|appos|END_ENTITY	Vascular endothelial tyrosine phosphatase -LRB- VE-PTP -RRB- - null mice undergo vasculogenesis but die embryonically because of defects in angiogenesis .
15791001	0	tyrosine	49,57	VE-cadherin	37,48	tyrosine	VE-cadherin	CHEBI:18186	12562(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Platelet-activating factor increases VE-cadherin tyrosine phosphorylation in mouse endothelial cells and its association with the PtdIns3 ' - kinase .
20048167	0	tyrosine	12,20	VE-cadherin	40,51	tyrosine	VE-cadherin	CHEBI:18186	1003	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Src-induced tyrosine phosphorylation of VE-cadherin is not sufficient to decrease barrier function of endothelial monolayers .
21444752	0	tyrosine	76,84	VE-cadherin	124,135	tyrosine	VE-cadherin	CHEBI:18186	12562(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	CRSBP-1 / LYVE-1 ligands disrupt lymphatic intercellular adhesion by inducing tyrosine phosphorylation and internalization of VE-cadherin .
24487320	0	tyrosine	91,99	VE-cadherin	112,123	tyrosine	VE-cadherin	CHEBI:18186	12562(Tax:10090)	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	Leukocyte extravasation and vascular permeability are each controlled in vivo by different tyrosine residues of VE-cadherin .
9625748	0	tyrosine	55,63	VE-cadherin	43,54	tyrosine	VE-cadherin	CHEBI:18186	1003	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Vascular_endothelial_growth_factor induces VE-cadherin tyrosine phosphorylation in endothelial cells .
10564161	0	tyrosine	16,24	VEGF	0,4	tyrosine	VEGF	CHEBI:18186	281572(Tax:9913)	Chemical	Gene	phosphorylation|amod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	VEGF stimulates tyrosine phosphorylation of beta-catenin and small-pore endothelial barrier dysfunction .
10639280	0	tyrosine	82,90	VEGF	68,72	tyrosine	VEGF	CHEBI:18186	7422	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Design and structure-activity relationship of a new class of potent VEGF receptor tyrosine kinase inhibitors .
10956210	1	tyrosine	181,189	VEGF	167,171	tyrosine	VEGF	CHEBI:18186	7422	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Application to HIV-1 protease inhibitors and VEGF receptor tyrosine kinase inhibitors .
11881999	0	tyrosine	151,159	VEGF	137,141	tyrosine	VEGF	CHEBI:18186	22339(Tax:10090)	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Novel 4-anilinoquinazolines with C-7 basic side chains : design and structure activity relationship of a series of potent , orally active , VEGF receptor tyrosine kinase inhibitors .
15596048	0	tyrosine	46,54	VEGF	32,36	tyrosine	VEGF	CHEBI:18186	22339(Tax:10090)	Chemical	Gene	inhibitor|compound|START_ENTITY inhibitor|compound|END_ENTITY	Anticancer effects of ZD6474 , a VEGF receptor tyrosine kinase inhibitor , in gefitinib -LRB- `` Iressa '' -RRB- - sensitive and resistant xenograft models .
15886878	0	tyrosine	18,26	VEGF	4,8	tyrosine	VEGF	CHEBI:18186	22339(Tax:10090)	Chemical	Gene	inhibitor|compound|START_ENTITY inhibitor|compound|END_ENTITY	The VEGF receptor tyrosine kinase inhibitor , ZD6474 , inhibits angiogenesis and affects microvascular architecture within an orthotopically implanted renal_cell_carcinoma .
16216503	0	tyrosine	73,81	VEGF	59,63	tyrosine	VEGF	CHEBI:18186	7422	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Synthesis of a novel biotin-tagged photoaffinity probe for VEGF receptor tyrosine kinases .
16432165	0	tyrosine	107,115	VEGF	91,95	tyrosine	VEGF	CHEBI:18186	83785(Tax:10116)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Improvement by solid dispersion of the bioavailability of KRN633 , a selective inhibitor of VEGF receptor-2 tyrosine kinase , and identification of its potential therapeutic window .
17371720	0	tyrosine	46,54	VEGF	32,36	tyrosine	VEGF	CHEBI:18186	7422	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	AG-013736 , a novel inhibitor of VEGF receptor tyrosine kinases , inhibits breast_cancer growth and decreases vascular permeability as detected by dynamic contrast-enhanced magnetic resonance imaging .
19037839	0	tyrosine	27,35	VEGF	13,17	tyrosine	VEGF	CHEBI:18186	7422	Chemical	Gene	START_ENTITY|nsubj|receptor receptor|compound|END_ENTITY	Pazopanib , a VEGF receptor tyrosine kinase inhibitor for cancer therapy .
20156808	0	tyrosine	107,115	VEGF	93,97	tyrosine	VEGF	CHEBI:18186	7422	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Bevacizumab salvage therapy following progression in high-grade glioma patients treated with VEGF receptor tyrosine kinase inhibitors .
21378200	0	tyrosine	49,57	VEGF	35,39	tyrosine	VEGF	CHEBI:18186	7422	Chemical	Gene	START_ENTITY|nsubj|receptor receptor|compound|END_ENTITY	Phase I evaluation of telatinib , a VEGF receptor tyrosine kinase inhibitor , in combination with bevacizumab in subjects with advanced solid tumors .
23414235	0	tyrosine	42,50	VEGF	28,32	tyrosine	VEGF	CHEBI:18186	7422	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Vegfrecine , an inhibitor of VEGF receptor tyrosine kinases isolated from the culture broth of Streptomyces sp .
24927771	0	tyrosine	85,93	VEGF	71,75	tyrosine	VEGF	CHEBI:18186	7422	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Risk of thyroid_dysfunction in patients with solid_tumors treated with VEGF receptor tyrosine kinase inhibitors : a critical literature review and meta analysis .
8983073	0	tyrosine	33,41	VEGF-FLT	24,32	tyrosine	VEGF-FLT	CHEBI:18186	7422;2321	Chemical	Gene	START_ENTITY|nsubj|involvement involvement|nmod|END_ENTITY	Possible involvement of VEGF-FLT tyrosine kinase receptor system in normal and tumor angiogenesis .
15771417	0	tyrosine	71,79	VEGF-R2	57,64	tyrosine	VEGF-R2	CHEBI:18186	25589(Tax:10116)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	2-Hydroxy-4 ,6 - diamino - -LSB- 1,3,5 -RSB- triazines : a novel class of VEGF-R2 -LRB- KDR -RRB- tyrosine kinase inhibitors .
20430619	0	tyrosine	63,71	VEGF-R2	46,53	tyrosine	VEGF-R2	CHEBI:18186	3791	Chemical	Gene	START_ENTITY|nsubj|receptor receptor|compound|END_ENTITY	8-THP-DHI analogs as potent Type I dual TIE-2 / VEGF-R2 receptor tyrosine kinase inhibitors .
20071170	0	tyrosine	54,62	VEGFR	39,44	tyrosine	VEGFR	CHEBI:18186	3791	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Identification of potent and selective VEGFR receptor tyrosine kinase inhibitors having new amide isostere headgroups .
21318618	0	tyrosine	39,47	VEGFR	33,38	tyrosine	VEGFR	CHEBI:18186	3791	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Development of second-generation VEGFR tyrosine kinase inhibitors : current status .
22363548	0	tyrosine	47,55	VEGFR	27,32	tyrosine	VEGFR	CHEBI:18186	3791	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|compound|END_ENTITY	Integrin b3 crosstalk with VEGFR accommodating tyrosine phosphorylation as a regulatory switch .
19754810	0	tyrosine	23,31	VEGFR-1	40,47	tyrosine	VEGFR-1	CHEBI:18186	2321	Chemical	Gene	Expression|nmod|START_ENTITY kinases|nsubj|Expression kinases|dobj|END_ENTITY	Expression of receptor tyrosine kinases VEGFR-1 -LRB- FLT-1 -RRB- , VEGFR-2 -LRB- KDR -RRB- , EGFR-1 , PDGFRalpha and c-Met in canine primary brain_tumours .
11960378	0	tyrosine	129,137	VEGFR-2	155,162	tyrosine	VEGFR-2	CHEBI:18186	3791	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Constitutive activation of Stat3alpha in brain_tumors : localization to tumor endothelial cells and activation by the endothelial tyrosine kinase receptor -LRB- VEGFR-2 -RRB- .
12881528	0	tyrosine	152,160	VEGFR-2	95,102	tyrosine	VEGFR-2	CHEBI:18186	3791	Chemical	Gene	sites|amod|START_ENTITY regulates|dobj|sites regulates|nsubj|vascular_endothelial_growth_factor_receptor-3 vascular_endothelial_growth_factor_receptor-3|acl|heterodimerization heterodimerization|nmod|END_ENTITY	Ligand-induced vascular_endothelial_growth_factor_receptor-3 -LRB- VEGFR-3 -RRB- heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites .
12881528	8	tyrosine	1351,1359	VEGFR-2	1224,1231	tyrosine	VEGFR-2	CHEBI:18186	3791	Chemical	Gene	residues|compound|START_ENTITY phosphorylated|nmod|residues cells|acl:relcl|phosphorylated cells|acl|induced induced|dobj|formation formation|nmod|heterodimers heterodimers|compound|END_ENTITY	Interestingly , VEGF-C stimulation of lymphatic endothelial cells also induced the formation of VEGFR-3 / VEGFR-2 heterodimers , in which VEGFR-3 was phosphorylated only at three of the five sites while the two most carboxyl-terminal tyrosine residues appeared not to be accessible for the VEGFR-2 kinase .
15743179	0	tyrosine	45,53	VEGFR-2	37,44	tyrosine	VEGFR-2	CHEBI:18186	3791	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Novel potent orally active selective VEGFR-2 tyrosine kinase inhibitors : synthesis , structure-activity relationships , and antitumor activities of N-phenyl-N ' - -LCB- 4 - -LRB- 4-quinolyloxy -RRB- phenyl -RCB- ureas .
19754810	0	tyrosine	23,31	VEGFR-2	57,64	tyrosine	VEGFR-2	CHEBI:18186	3791	Chemical	Gene	Expression|nmod|START_ENTITY kinases|nsubj|Expression kinases|dobj|VEGFR-1 VEGFR-1|appos|END_ENTITY	Expression of receptor tyrosine kinases VEGFR-1 -LRB- FLT-1 -RRB- , VEGFR-2 -LRB- KDR -RRB- , EGFR-1 , PDGFRalpha and c-Met in canine primary brain_tumours .
19832844	0	tyrosine	32,40	VEGFR-2	24,31	tyrosine	VEGFR-2	CHEBI:18186	16542(Tax:10090)	Chemical	Gene	inhibitor|compound|START_ENTITY inhibitor|compound|END_ENTITY	E7050 : a dual c-Met and VEGFR-2 tyrosine kinase inhibitor promotes tumor regression and prolongs survival in mouse xenograft models .
19924384	0	tyrosine	53,61	VEGFR-2	33,40	tyrosine	VEGFR-2	CHEBI:18186	3791	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Pharmacogenetics of telatinib , a VEGFR-2 and VEGFR-3 tyrosine kinase inhibitor , used in patients with solid tumors .
20188461	0	tyrosine	67,75	VEGFR-2	95,102	tyrosine	VEGFR-2	CHEBI:18186	16542(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Bee venom inhibits tumor angiogenesis and metastasis by inhibiting tyrosine phosphorylation of VEGFR-2 in LLC-tumor-bearing mice .
21353546	0	tyrosine	84,92	VEGFR-2	67,74	tyrosine	VEGFR-2	CHEBI:18186	3791	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Impact of aryloxy-linked quinazolines : a novel series of selective VEGFR-2 receptor tyrosine kinase inhibitors .
21441409	0	tyrosine	49,57	VEGFR-2	39,46	tyrosine	VEGFR-2	CHEBI:18186	16542(Tax:10090)	Chemical	Gene	inhibitor|amod|START_ENTITY /|dobj|inhibitor /|nsubj|END_ENTITY	Assessing the activity of cediranib , a VEGFR-2 / 3 tyrosine kinase inhibitor , against VEGFR-1 and members of the structurally related PDGFR family .
21567184	0	tyrosine	54,62	VEGFR-2	83,90	tyrosine	VEGFR-2	CHEBI:18186	3791	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|nmod|END_ENTITY	A phase I pharmacokinetic study of TSU-68 -LRB- a multiple tyrosine kinase inhibitor of VEGFR-2 , FGF and PDFG -RRB- in combination with S-1_and_oxaliplatin in metastatic colorectal_cancer patients previously treated with chemotherapy .
22153662	0	tyrosine	97,105	VEGFR-2	79,86	tyrosine	VEGFR-2	CHEBI:18186	3791	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Discovery of AZD2932 , a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases .
23016841	0	tyrosine	75,83	VEGFR-2	66,73	tyrosine	VEGFR-2	CHEBI:18186	3791	Chemical	Gene	START_ENTITY|nsubj|QSARs QSARs|nmod|vascular_endothelial_growth_factor_receptor-2 vascular_endothelial_growth_factor_receptor-2|appos|END_ENTITY	Exploring QSARs of vascular_endothelial_growth_factor_receptor-2 -LRB- VEGFR-2 -RRB- tyrosine kinase inhibitors by MLR , PLS and PC-ANN .
23131541	0	tyrosine	103,111	VEGFR-2	132,139	tyrosine	VEGFR-2	CHEBI:18186	25589(Tax:10116)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|nmod|END_ENTITY	Synthesis , in silico , in vitro , and in vivo investigation of 5 - -LSB- ____ C -RSB- methoxy-substituted_sunitinib , a tyrosine kinase inhibitor of VEGFR-2 .
23715382	0	tyrosine	72,80	VEGFR-2	64,71	tyrosine	VEGFR-2	CHEBI:18186	3791	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Novel 5-anilinoquinazoline-8-nitro derivatives as inhibitors of VEGFR-2 tyrosine kinase : synthesis , biological evaluation and molecular docking .
26416217	0	tyrosine	70,78	VEGFR-2	62,69	tyrosine	VEGFR-2	D014443	3791	Chemical	Gene	START_ENTITY|nsubj|studies studies|nmod|derivatives derivatives|nmod|END_ENTITY	QSAR and molecular docking studies on oxindole derivatives as VEGFR-2 tyrosine kinase inhibitors .
26446815	0	tyrosine	116,124	VEGFR-2	108,115	tyrosine	VEGFR-2	D014443	3791	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Wild Roman chamomile extracts and phenolic compounds : enzymatic assays and molecular modelling studies with VEGFR-2 tyrosine kinase .
8617204	0	tyrosine	114,122	VEGFR-2	96,103	tyrosine	VEGFR-2	CHEBI:18186	3791	Chemical	Gene	kinases|compound|START_ENTITY kinases|amod|ligand ligand|nmod|Flt4 Flt4|appos|END_ENTITY	A novel vascular_endothelial_growth_factor , VEGF-C , is a ligand for the Flt4 -LRB- VEGFR-3 -RRB- and KDR -LRB- VEGFR-2 -RRB- receptor tyrosine kinases .
8617204	0	tyrosine	114,122	VEGFR-3	78,85	tyrosine	VEGFR-3	CHEBI:18186	2324	Chemical	Gene	kinases|compound|START_ENTITY kinases|amod|ligand ligand|nmod|Flt4 Flt4|appos|END_ENTITY	A novel vascular_endothelial_growth_factor , VEGF-C , is a ligand for the Flt4 -LRB- VEGFR-3 -RRB- and KDR -LRB- VEGFR-2 -RRB- receptor tyrosine kinases .
18174461	0	tyrosine	7,15	VEGFR1	0,6	tyrosine	VEGFR1	CHEBI:18186	14254(Tax:10090)	Chemical	Gene	kinase|amod|START_ENTITY kinase|nummod|END_ENTITY	VEGFR1 tyrosine kinase signaling promotes lymphangiogenesis as well as angiogenesis indirectly via macrophage recruitment .
19162007	0	tyrosine	16,24	VEGFR1	0,6	tyrosine	VEGFR1	CHEBI:18186	2321	Chemical	Gene	localization|compound|START_ENTITY localization|compound|END_ENTITY	VEGFR1 receptor tyrosine kinase localization to the Golgi apparatus is calcium-dependent .
15990302	0	tyrosine	105,113	VEGFR2	98,104	tyrosine	VEGFR2	CHEBI:18186	3791	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Discovery of a novel and potent series of dianilinopyrimidineurea and urea isostere inhibitors of VEGFR2 tyrosine kinase .
18378261	0	tyrosine	89,97	VEGFR2	117,123	tyrosine	VEGFR2	CHEBI:18186	3791	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Wogonin suppresses tumor growth in vivo and VEGF-induced angiogenesis through inhibiting tyrosine phosphorylation of VEGFR2 .
21539813	0	tyrosine	20,28	VEGFR2	4,10	tyrosine	VEGFR2	CHEBI:18186	3791	Chemical	Gene	START_ENTITY|nsubj|receptor receptor|compound|END_ENTITY	The VEGFR2 receptor tyrosine kinase undergoes constitutive endosome-to-plasma membrane recycling .
22141913	0	tyrosine	113,121	VEGFR2	97,103	tyrosine	VEGFR2	CHEBI:18186	3791	Chemical	Gene	START_ENTITY|nsubj|receptor receptor|compound|END_ENTITY	A combinatorial in silico and cellular approach to identify a new class of compounds that target VEGFR2 receptor tyrosine kinase activity and angiogenesis .
18695882	0	tyrosine	32,40	VEGF_receptor	18,31	tyrosine	VEGF receptor	CHEBI:18186	3791	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	Administration of VEGF_receptor tyrosine kinase inhibitor increases VEGF production causing angiogenesis in human_small-cell_lung_cancer xenografts .
11971192	0	tyrosine	25,33	VHR	46,49	tyrosine	VHR	CHEBI:18186	1845	Chemical	Gene	phosphatase|nsubj|START_ENTITY phosphatase|dobj|END_ENTITY	Dual-specificity protein tyrosine phosphatase VHR down-regulates c-Jun_N-terminal_kinase -LRB- JNK -RRB- .
2460071	0	tyrosine	145,153	VIP	140,143	tyrosine	VIP	CHEBI:18186	7432	Chemical	Gene	START_ENTITY|nsubj|studies studies|nmod|END_ENTITY	Immunohistochemical studies of the neurochemical markers , CGRP , enkephalin , galanin , gamma-MSH , NPY , PHI , proctolin , PTH , somatostatin , SP , VIP , tyrosine hydroxylase and neurofilament in nerves and cells of the human attached_gingiva .
7896817	0	tyrosine	49,57	Vascular_endothelial_cell_growth_factor	0,39	tyrosine	Vascular endothelial cell growth factor	CHEBI:18186	281572(Tax:9913)	Chemical	Gene	phosphorylation|amod|START_ENTITY promotes|dobj|phosphorylation promotes|nsubj|END_ENTITY	Vascular_endothelial_cell_growth_factor promotes tyrosine phosphorylation of mediators of signal transduction that contain SH2 domains .
10037737	0	tyrosine	48,56	Vascular_endothelial_growth_factor	0,34	tyrosine	Vascular endothelial growth factor	CHEBI:18186	7422	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Vascular_endothelial_growth_factor receptor KDR tyrosine kinase activity is increased by autophosphorylation of two activation loop tyrosine residues .
12802793	0	tyrosine	44,52	Vascular_endothelial_growth_factor	0,34	tyrosine	Vascular endothelial growth factor	CHEBI:18186	7422	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|amod|END_ENTITY	Vascular_endothelial_growth_factor receptor tyrosine kinase inhibitors : PTK787/ZK _ 222584 .
17671152	0	tyrosine	44,52	Vascular_endothelial_growth_factor	0,34	tyrosine	Vascular endothelial growth factor	CHEBI:18186	7422	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Vascular_endothelial_growth_factor receptor tyrosine kinase inhibitors vandetanib -LRB- ZD6474 -RRB- and AZD2171 in lung_cancer .
18473996	0	tyrosine	44,52	Vascular_endothelial_growth_factor	0,34	tyrosine	Vascular endothelial growth factor	CHEBI:18186	7422	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|amod|END_ENTITY	Vascular_endothelial_growth_factor receptor tyrosine kinase inhibitors in non-small_cell_lung_cancer : a review of recent clinical trials .
20837456	0	tyrosine	44,52	Vascular_endothelial_growth_factor	0,34	tyrosine	Vascular endothelial growth factor	CHEBI:18186	7422	Chemical	Gene	START_ENTITY|nsubj|receptor receptor|amod|END_ENTITY	Vascular_endothelial_growth_factor receptor tyrosine kinase inhibitors in non-small-cell_lung_cancer .
9182576	0	tyrosine	46,54	Vascular_endothelial_growth_factor	0,34	tyrosine	Vascular endothelial growth factor	CHEBI:18186	7422	Chemical	Gene	phosphorylation|amod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Vascular_endothelial_growth_factor stimulates tyrosine phosphorylation and recruitment to new focal adhesions of focal adhesion kinase and paxillin in endothelial cells .
9625748	0	tyrosine	55,63	Vascular_endothelial_growth_factor	0,34	tyrosine	Vascular endothelial growth factor	CHEBI:18186	7422	Chemical	Gene	phosphorylation|compound|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Vascular_endothelial_growth_factor induces VE-cadherin tyrosine phosphorylation in endothelial cells .
26171215	0	tyrosine	44,52	Vascular_endothelial_growth_factor_receptor	0,43	tyrosine	Vascular endothelial growth factor receptor	D014443	3791	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Vascular_endothelial_growth_factor_receptor tyrosine kinase inhibitors versus bevacizumab in metastatic colorectal_cancer : A systematic review and meta-analysis .
10971393	0	tyrosine	33,41	Vav	61,64	tyrosine	Vav	CHEBI:18186	7409	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Lack of interferon-alpha-induced tyrosine phosphorylation of Vav proto-oncogene in patients with myelofibrosis with myeloid_metaplasia .
11007481	0	tyrosine	98,106	Vav	91,94	tyrosine	Vav	CHEBI:18186	7409	Chemical	Gene	phosphorylation|amod|START_ENTITY END_ENTITY|nmod|phosphorylation	Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation .
7527668	0	tyrosine	13,21	Vav	41,44	tyrosine	Vav	CHEBI:18186	7409	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Induction of tyrosine phosphorylation of Vav and expression of Pim-1 correlates with Jak2-mediated growth signaling from the erythropoietin_receptor .
8710888	0	tyrosine	116,124	Vav	170,173	tyrosine	Vav	CHEBI:18186	7409	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Antibody-induced engagement of beta_2 integrins on adherent human neutrophils triggers activation of p21ras through tyrosine phosphorylation of the protooncogene product Vav .
9013873	2	tyrosine	240,248	Vav	268,271	tyrosine	Vav	CHEBI:18186	7409	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	We show that interleukin-6 -LRB- IL-6 -RRB- induces transient tyrosine phosphorylation of Vav in a human myeloma cell line , U266 .
9108397	0	tyrosine	35,43	Vav	63,66	tyrosine	Vav	CHEBI:18186	7409	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Thrombopoietin and thrombin induce tyrosine phosphorylation of Vav in human blood platelets .
9186005	0	tyrosine	35,43	Vav	90,93	tyrosine	Vav	CHEBI:18186	7409	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Cross-linking of integrins induces tyrosine phosphorylation of the proto-oncogene product Vav and the protein tyrosine kinase Syk in human factor-dependent myeloid cells .
9603925	0	tyrosine	57,65	Vav	53,56	tyrosine	Vav	CHEBI:18186	7409	Chemical	Gene	phosphorylation|amod|START_ENTITY END_ENTITY|dobj|phosphorylation	T cell activation through the CD43 molecule leads to Vav tyrosine phosphorylation and mitogen-activated protein kinase pathway activation .
9620604	0	tyrosine	77,85	Vav	105,108	tyrosine	Vav	CHEBI:18186	7409	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Two distinct regions of the CD28 intracytoplasmic domain are involved in the tyrosine phosphorylation of Vav and GTPase activating protein-associated p62 protein .
22677173	0	tyrosine	35,43	Vps33B	98,104	tyrosine	Vps33B	CHEBI:18186	26276	Chemical	Gene	START_ENTITY|nmod|function function|nmod|END_ENTITY	Inhibitory effect of SPE-39 due to tyrosine phosphorylation and ubiquitination on the function of Vps33B in the EGF-stimulated cells .
14707117	0	tyrosine	80,88	WASp	74,78	tyrosine	WASp	CHEBI:18186	22376(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|appos|END_ENTITY	Fyn and PTP-PEST-mediated regulation of Wiskott-Aldrich_syndrome protein -LRB- WASp -RRB- tyrosine phosphorylation is required for coupling T cell antigen receptor engagement to WASp effector function and T cell activation .
23537585	0	tyrosine	5,13	WEE1	0,4	tyrosine	WEE1	CHEBI:18186	7465	Chemical	Gene	kinase|amod|START_ENTITY kinase|nummod|END_ENTITY	WEE1 tyrosine kinase , a novel epigenetic modifier .
21807898	0	tyrosine	138,146	WNK4	122,126	tyrosine	WNK4	CHEBI:18186	65266	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Antagonistic regulation of cystic_fibrosis_transmembrane_conductance_regulator cell surface expression by protein kinases WNK4 and spleen tyrosine kinase .
18371080	0	tyrosine	45,53	WOX1	112,116	tyrosine	WOX1	CHEBI:18186	51741	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	MPP + - induced neuronal_death in rats involves tyrosine 33 phosphorylation of WW domain-containing oxidoreductase WOX1 .
12944467	0	tyrosine	47,55	Werner_syndrome_protein	0,23	tyrosine	Werner syndrome protein	CHEBI:18186	7486	Chemical	Gene	kinase|compound|START_ENTITY phosphorylation|nmod|kinase phosphorylation|compound|END_ENTITY	Werner_syndrome_protein phosphorylation by abl tyrosine kinase regulates its activity and distribution .
12399314	0	tyrosine	21,29	Xror2	37,42	tyrosine	Xror2	D014443	398399(Tax:8355)	Chemical	Gene	START_ENTITY|ccomp|modulates modulates|nsubj|END_ENTITY	The Xenopus receptor tyrosine kinase Xror2 modulates morphogenetic movements of the axial mesoderm and neuroectoderm via Wnt signaling .
21671403	0	tyrosine	126,134	YopH	148,152	tyrosine	YopH	CHEBI:18186	15151821	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|appos|END_ENTITY	Oxime-based click chemistry in the development of 3-isoxazolecarboxylic_acid containing inhibitors of Yersinia_pestis protein tyrosine phosphatase , YopH .
10358158	0	tyrosine	45,53	ZAP-70	24,30	tyrosine	ZAP-70	CHEBI:18186	22637(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Perturbed regulation of ZAP-70 and sustained tyrosine phosphorylation of LAT and SLP-76 in c-Cbl-deficient thymocytes .
10510363	0	tyrosine	67,75	ZAP-70	59,65	tyrosine	ZAP-70	CHEBI:18186	7535	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	LFA-1 to LFA-1 signals involve zeta-associated_protein-70 -LRB- ZAP-70 -RRB- tyrosine kinase : relevance for invasion and migration of a T cell hybridoma .
11090635	0	tyrosine	82,90	ZAP-70	67,73	tyrosine	ZAP-70	CHEBI:18186	7535	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	A peptide library approach identifies a specific inhibitor for the ZAP-70 protein tyrosine kinase .
11489961	0	tyrosine	89,97	ZAP-70	82,88	tyrosine	ZAP-70	CHEBI:18186	7535	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Cutting edge : T cell migration regulated by CXCR4 chemokine receptor signaling to ZAP-70 tyrosine kinase .
11514605	0	tyrosine	116,124	ZAP-70	101,107	tyrosine	ZAP-70	CHEBI:18186	22637(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	T cell development and T cell responses in mice with mutations affecting tyrosines 292 or 315 of the ZAP-70 protein tyrosine kinase .
11744042	0	tyrosine	38,46	ZAP-70	66,72	tyrosine	ZAP-70	CHEBI:18186	7535	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Effect of age and oxidative stress on tyrosine phosphorylation of ZAP-70 .
12591907	0	tyrosine	146,154	ZAP-70	139,145	tyrosine	ZAP-70	CHEBI:18186	22637(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	A mouse with a loss-of-function mutation in the c-Cbl TKB domain shows perturbed thymocyte signaling without enhancing the activity of the ZAP-70 tyrosine kinase .
15996927	0	tyrosine	7,15	ZAP-70	0,6	tyrosine	ZAP-70	CHEBI:18186	7535	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	ZAP-70 tyrosine kinase is constitutively expressed and phosphorylated in B-lineage_acute_lymphoblastic_leukemia cells .
7538440	0	tyrosine	53,61	ZAP-70	38,44	tyrosine	ZAP-70	CHEBI:18186	7535	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Reconstitution of Syk function by the ZAP-70 protein tyrosine kinase .
7693848	0	tyrosine	72,80	ZAP-70	65,71	tyrosine	ZAP-70	CHEBI:18186	7535	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The CD3 chains of the T_cell_antigen_receptor associate with the ZAP-70 tyrosine kinase and are tyrosine phosphorylated after receptor stimulation .
8176201	0	tyrosine	50,58	ZAP-70	27,33	tyrosine	ZAP-70	CHEBI:18186	7535	Chemical	Gene	kinases|compound|START_ENTITY kinases|amod|END_ENTITY	Differential expression of ZAP-70 and Syk protein tyrosine kinases , and the role of this family of protein tyrosine kinases in TCR signaling .
8202712	0	tyrosine	75,83	ZAP-70	58,64	tyrosine	ZAP-70	CHEBI:18186	7535	Chemical	Gene	kinase|compound|START_ENTITY END_ENTITY|appos|kinase	Human severe combined immunodeficiency due to a defect in ZAP-70 , a T cell tyrosine kinase .
8756661	0	tyrosine	9,17	ZAP-70	43,49	tyrosine	ZAP-70	CHEBI:18186	22637(Tax:10090)	Chemical	Gene	sites|amod|START_ENTITY sites|nmod|END_ENTITY	Distinct tyrosine phosphorylation sites in ZAP-70 mediate activation and negative regulation of antigen receptor function .
9199177	0	tyrosine	15,23	ZAP-70	0,6	tyrosine	ZAP-70	CHEBI:18186	7535	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	ZAP-70 protein tyrosine kinase is constitutively targeted to the T cell cortex independently of its SH2 domains .
9233606	0	tyrosine	7,15	ZAP-70	0,6	tyrosine	ZAP-70	CHEBI:18186	7535	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	ZAP-70 tyrosine kinase is required for the up-regulation of Fas_ligand in activation-induced T cell apoptosis .
9275205	0	tyrosine	34,42	ZAP-70	12,18	tyrosine	ZAP-70	CHEBI:18186	22637(Tax:10090)	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling .
9464824	0	tyrosine	47,55	ZAP-70	24,30	tyrosine	ZAP-70	CHEBI:18186	7535	Chemical	Gene	kinases|amod|START_ENTITY kinases|compound|END_ENTITY	A dual participation of ZAP-70 and scr protein tyrosine kinases is required for TCR-induced tyrosine phosphorylation of Sam68 in Jurkat T cells .
9723707	0	tyrosine	32,40	ZAP-70	60,66	tyrosine	ZAP-70	CHEBI:18186	22637(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Ex vivo evidence for asymmetric tyrosine phosphorylation of ZAP-70 on double-positive thymocytes in the positive selection process .
9732296	0	tyrosine	7,15	ZAP-70	0,6	tyrosine	ZAP-70	CHEBI:18186	22637(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	ZAP-70 tyrosine kinase is required for LFA-1-dependent T cell migration .
9751431	0	tyrosine	118,126	ZAP-70	146,152	tyrosine	ZAP-70	CHEBI:18186	7535	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Effect of age on mitogen induced protein tyrosine phosphorylation in human T cell and its subsets : down-regulation of tyrosine phosphorylation of ZAP-70 .
12708492	0	tyrosine	148,156	ZO-1	176,180	tyrosine	ZO-1	CHEBI:18186	7082	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Redifferentiation and ZO-1 reexpression in liver-metastasized colorectal_cancer : possible association with epidermal_growth_factor_receptor-induced tyrosine phosphorylation of ZO-1 .
7542259	0	tyrosine	32,40	ZO-1	106,110	tyrosine	ZO-1	CHEBI:18186	7082	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Epidermal_growth_factor induces tyrosine phosphorylation and reorganization of the tight junction protein ZO-1 in A431 cells .
16339550	0	tyrosine	61,69	Zap70	47,52	tyrosine	Zap70	CHEBI:18186	7535	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	T cell activation-induced CrkII binding to the Zap70 protein tyrosine kinase is mediated by Lck-dependent phosphorylation of Zap70 tyrosine 315 .
12951113	0	tyrosine	68,76	abl	64,67	tyrosine	abl	CHEBI:18186	25	Chemical	Gene	kinase|amod|START_ENTITY END_ENTITY|dobj|kinase	Synthesis of pyrimidinopyridine-triazene conjugates targeted to abl tyrosine kinase .
16640460	0	tyrosine	44,52	abl	40,43	tyrosine	abl	CHEBI:18186	25	Chemical	Gene	START_ENTITY|nsubj|conformation conformation|nmod|END_ENTITY	A Src-like inactive conformation in the abl tyrosine kinase domain .
20962097	0	tyrosine	124,132	abl	105,108	tyrosine	abl	CHEBI:18186	25	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Variola and monkeypox_viruses utilize conserved mechanisms of virion motility and release that depend on abl and SRC family tyrosine kinases .
2125038	0	tyrosine	27,35	abl	14,17	tyrosine	abl	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Inhibition of abl oncogene tyrosine kinase induces erythroid differentiation of human myelogenous_leukemia K562 cells .
23226578	0	tyrosine	58,66	abl	54,57	tyrosine	abl	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Crk and ABI1 : binary molecular switches that regulate abl tyrosine kinase and signaling to the cytoskeleton .
2502313	0	tyrosine	15,23	abl	11,14	tyrosine	abl	CHEBI:18186	45821(Tax:7227)	Chemical	Gene	kinase|amod|START_ENTITY END_ENTITY|dobj|kinase	Drosophila abl tyrosine kinase in embryonic CNS axons : a role in axonogenesis is revealed through dosage-sensitive interactions with disabled .
3879812	0	tyrosine	19,27	abl	101,104	tyrosine	abl	CHEBI:18186	25	Chemical	Gene	activity|amod|START_ENTITY Detection|nmod|activity permits|nsubj|Detection permits|dobj|comparison comparison|nmod|products products|compound|END_ENTITY	Detection of c-abl tyrosine kinase activity in vitro permits direct comparison of normal and altered abl gene products .
7925293	0	tyrosine	43,51	abl	30,33	tyrosine	abl	CHEBI:18186	11350(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY involves|dobj|phosphorylation involves|nsubj|induction induction|nmod|END_ENTITY	Tumour induction by activated abl involves tyrosine phosphorylation of the product of the cbl oncogene .
9275236	0	tyrosine	67,75	actin_depolymerizing_factor	94,121	tyrosine	actin depolymerizing factor	CHEBI:18186	542445(Tax:4577)	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	F-actin and G-actin binding are uncoupled by mutation of conserved tyrosine residues in maize actin_depolymerizing_factor -LRB- ZmADF -RRB- .
18073204	0	tyrosine	4,12	adaptor_protein_1	35,52	tyrosine	adaptor protein 1	CHEBI:18186	3725	Chemical	Gene	pocket|amod|START_ENTITY pocket|nmod|END_ENTITY	The tyrosine binding pocket in the adaptor_protein_1 -LRB- AP-1 -RRB- _ mu1 subunit is necessary for Nef to recruit AP-1 to the major histocompatibility complex class I cytoplasmic tail .
11802708	0	tyrosine	41,49	alpha-actinin	69,82	tyrosine	alpha-actinin	CHEBI:18186	87	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Pathological shear stress stimulates the tyrosine phosphorylation of alpha-actinin associated with the glycoprotein Ib-IX complex .
12096713	0	tyrosine	33,41	alpha-synuclein	61,76	tyrosine	alpha-synuclein	CHEBI:18186	6622	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Activation of Pyk2/RAFTK induces tyrosine phosphorylation of alpha-synuclein via Src-family kinases .
16733250	0	tyrosine	70,78	amphiphysin_I	19,32	tyrosine	amphiphysin I	CHEBI:18186	273	Chemical	Gene	kinase|amod|START_ENTITY END_ENTITY|nmod|kinase	Phosphorylation of amphiphysin_I by minibrain kinase/dual-specificity tyrosine phosphorylation-regulated kinase , a kinase implicated in Down syndrome .
17108144	0	tyrosine	63,71	androgen_receptor	108,125	tyrosine	androgen receptor	CHEBI:18186	367	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Receptor_for_activated_C_kinase_1 -LRB- RACK1 -RRB- and Src regulate the tyrosine phosphorylation and function of the androgen_receptor .
17494760	0	tyrosine	98,106	androgen_receptor	80,97	tyrosine	androgen receptor	CHEBI:18186	367	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Activated Cdc42-associated kinase Ack1 promotes prostate_cancer progression via androgen_receptor tyrosine phosphorylation .
20383201	0	tyrosine	33,41	androgen_receptor	61,78	tyrosine	androgen receptor	CHEBI:18186	367	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Dasatinib inhibits site-specific tyrosine phosphorylation of androgen_receptor by Ack1 and Src kinases .
20623637	0	tyrosine	15,23	androgen_receptor	63,80	tyrosine	androgen receptor	CHEBI:18186	367	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Effect of Ack1 tyrosine kinase inhibitor on ligand-independent androgen_receptor activity .
7685351	0	tyrosine	38,46	angiotensin_II	20,34	tyrosine	angiotensin II	CHEBI:18186	24179(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY END_ENTITY|nmod|phosphorylation	Sustained effect of angiotensin_II on tyrosine phosphorylation of annexin_I in glomerular mesangial cells .
8820403	0	tyrosine	12,20	angiotensin_II	40,54	tyrosine	angiotensin II	CHEBI:18186	24179(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	The role of tyrosine phosphorylation in angiotensin_II mediated intracellular signaling and cell growth .
9776731	0	tyrosine	58,66	angiotensin_II	82,96	tyrosine	angiotensin II	CHEBI:18186	24179(Tax:10116)	Chemical	Gene	activation|nmod|START_ENTITY kinase|nsubj|activation kinase|nmod|END_ENTITY	Calcium - and protein_kinase_C-dependent activation of the tyrosine kinase PYK2 by angiotensin_II in vascular smooth muscle .
8828496	0	tyrosine	23,31	annexin_I	51,60	tyrosine	annexin I	CHEBI:18186	25380(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Growth_hormone induces tyrosine phosphorylation of annexin_I in rat_osteosarcoma cells .
19639233	0	tyrosine	30,38	annexin_V	58,67	tyrosine	annexin V	CHEBI:18186	308	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Group_B_Streptococcus induces tyrosine phosphorylation of annexin_V and glutathione_S-transferase in human umbilical vein endothelial cells .
15777801	0	tyrosine	4,12	antithrombin	51,63	tyrosine	antithrombin	CHEBI:18186	462	Chemical	Gene	START_ENTITY|dobj|effects effects|nmod|END_ENTITY	Src tyrosine kinase-dependent migratory effects of antithrombin in leukocytes .
23690341	0	tyrosine	66,74	aquaporin-1	54,65	tyrosine	aquaporin-1	CHEBI:18186	358	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	The osmopressor response is linked to upregulation of aquaporin-1 tyrosine phosphorylation on red blood cell membranes .
11032419	0	tyrosine	88,96	aryl_hydrocarbon_receptor	59,84	tyrosine	aryl hydrocarbon receptor	CHEBI:18186	196	Chemical	Gene	phosphorylation|amod|START_ENTITY END_ENTITY|nmod|phosphorylation	Regulation of DNA binding activity of the ligand-activated aryl_hydrocarbon_receptor by tyrosine phosphorylation .
12646272	0	tyrosine	59,67	aryl_hydrocarbon_receptor	33,58	tyrosine	aryl hydrocarbon receptor	CHEBI:18186	11622(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|analysis analysis|nmod|END_ENTITY	Mutational analysis of the mouse aryl_hydrocarbon_receptor tyrosine residues necessary for recognition of dioxin response elements .
15451023	0	tyrosine	71,79	aryl_hydrocarbon_receptor	14,39	tyrosine	aryl hydrocarbon receptor	CHEBI:18186	196	Chemical	Gene	kinases|compound|START_ENTITY signal|nmod|kinases signal|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of aryl_hydrocarbon_receptor signal transduction by protein tyrosine kinases .
19500377	0	tyrosine	35,43	aryl_hydrocarbon_receptor	75,100	tyrosine	aryl hydrocarbon receptor	CHEBI:18186	196	Chemical	Gene	regulation|nmod|START_ENTITY dioxins|nmod|regulation Effect|nmod|dioxins hydroxylase|nsubj|Effect hydroxylase|nmod|END_ENTITY	Effect of dioxins on regulation of tyrosine hydroxylase gene expression by aryl_hydrocarbon_receptor : a neurotoxicology study .
20057149	0	tyrosine	33,41	aryl_hydrocarbon_receptor	139,164	tyrosine	aryl hydrocarbon receptor	CHEBI:18186	196	Chemical	Gene	kinase|amod|START_ENTITY mechanisms|nmod|kinase inhibitors|nsubj|mechanisms inhibitors|nmod|function function|nmod|END_ENTITY	The inhibitory mechanisms of the tyrosine kinase inhibitors herbimycin_a , genistein , and tyrphostin_B48 with regard to the function of the aryl_hydrocarbon_receptor in Caco-2 cells .
21145940	0	tyrosine	25,33	aryl_hydrocarbon_receptor	71,96	tyrosine	aryl hydrocarbon receptor	CHEBI:18186	196	Chemical	Gene	analysis|nmod|START_ENTITY kinase|nsubj|analysis kinase|dobj|mediated mediated|nmod|END_ENTITY	FRET analysis of protein tyrosine kinase c-Src activation mediated via aryl_hydrocarbon_receptor .
23288144	0	tyrosine	13,21	aryl_hydrocarbon_receptor	134,159	tyrosine	aryl hydrocarbon receptor	CHEBI:18186	196	Chemical	Gene	kinase|amod|START_ENTITY inhibitor|amod|kinase Sunitinib|appos|inhibitor induces|nsubj|Sunitinib induces|nmod|activation activation|compound|END_ENTITY	Sunitinib , a tyrosine kinase inhibitor , induces cytochrome_P450_1A1 gene in human breast_cancer MCF7 cells through ligand-independent aryl_hydrocarbon_receptor activation .
1656220	0	tyrosine	102,110	axl	0,3	tyrosine	axl	CHEBI:18186	558	Chemical	Gene	kinase|compound|START_ENTITY encodes|dobj|kinase encodes|nsubj|END_ENTITY	axl , a transforming gene isolated from primary human myeloid_leukemia cells , encodes a novel receptor tyrosine kinase .
7521695	0	tyrosine	43,51	axl	14,17	tyrosine	axl	CHEBI:18186	558	Chemical	Gene	kinase|amod|START_ENTITY Expression|amod|kinase Expression|nmod|END_ENTITY	Expression of axl , a transforming receptor tyrosine kinase , in normal and malignant hematopoiesis .
22126602	0	tyrosine	52,60	b-catenin	105,114	tyrosine	b-catenin	CHEBI:18186	1499	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Y654 of b-catenin is essential for FLT3/ITD-related tyrosine phosphorylation and nuclear localization of b-catenin .
22340496	0	tyrosine	69,77	b-catenin	59,68	tyrosine	b-catenin	CHEBI:18186	31151(Tax:7227)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Abl regulates planar polarized junctional dynamics through b-catenin tyrosine phosphorylation .
25344320	0	tyrosine	32,40	b-catenin	83,92	tyrosine	b-catenin	D014443	1499	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|nmod|END_ENTITY	Claudin-4 controls the receptor tyrosine kinase EphA2 pro-oncogenic switch through b-catenin .
10716894	0	tyrosine	51,59	basic_fibroblast_growth_factor	9,39	tyrosine	basic fibroblast growth factor	CHEBI:18186	396413(Tax:9031)	Chemical	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Role for basic_fibroblast_growth_factor -LRB- FGF-2 -RRB- in tyrosine kinase -LRB- TrkB -RRB- expression in the early development and innervation of the auditory receptor : in vitro and in situ studies .
11085460	0	tyrosine	18,26	bcr-abl	10,17	tyrosine	bcr-abl	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Status of bcr-abl tyrosine kinase inhibitors in chronic_myelogenous_leukemia .
19466505	0	tyrosine	90,98	bcr-abl	131,138	tyrosine	bcr-abl	CHEBI:18186	25	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|gene gene|amod|END_ENTITY	High-resolution melting analysis for a reliable and two-step scanning of mutations in the tyrosine kinase domain of the chimerical bcr-abl gene .
10541288	0	tyrosine	24,32	beta-catenin	52,64	tyrosine	beta-catenin	CHEBI:18186	12387(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	ATP depletion increases tyrosine phosphorylation of beta-catenin and plakoglobin in renal tubular cells .
10684725	0	tyrosine	99,107	beta-catenin	129,141	tyrosine	beta-catenin	CHEBI:18186	395964(Tax:9031)	Chemical	Gene	dephosphorylation|amod|START_ENTITY dephosphorylation|nmod|END_ENTITY	Restrictive endothelial barrier function during normal angiogenesis in vivo : partial dependence on tyrosine dephosphorylation of beta-catenin .
10706604	0	tyrosine	31,39	beta-catenin	64,76	tyrosine	beta-catenin	CHEBI:18186	1499	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Pleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase beta/zeta .
11024053	0	tyrosine	88,96	beta-catenin	116,128	tyrosine	beta-catenin	CHEBI:18186	12387(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	The addition of bisecting N-acetylglucosamine residues to E-cadherin down-regulates the tyrosine phosphorylation of beta-catenin .
12176729	0	tyrosine	33,41	beta-catenin	20,32	tyrosine	beta-catenin	CHEBI:18186	1499	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Polyamines regulate beta-catenin tyrosine phosphorylation via Ca -LRB- 2 + -RRB- during intestinal epithelial cell migration .
12920240	0	tyrosine	60,68	beta-catenin	47,59	tyrosine	beta-catenin	CHEBI:18186	12387(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Vascular_endothelial_growth_factor expression , beta-catenin tyrosine phosphorylation , and endothelial proliferative behavior : a pathway for transformation ?
15352211	0	tyrosine	89,97	beta-catenin	117,129	tyrosine	beta-catenin	CHEBI:18186	84353(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	A sulfatase regulating the migratory potency of oligodendrocyte progenitor cells through tyrosine phosphorylation of beta-catenin .
15705912	0	tyrosine	31,39	beta-catenin	18,30	tyrosine	beta-catenin	CHEBI:18186	12387(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Carnosol inhibits beta-catenin tyrosine phosphorylation and prevents adenoma formation in the C57BL/6J/Min / + -LRB- Min / + -RRB- mouse .
15778498	0	tyrosine	129,137	beta-catenin	116,128	tyrosine	beta-catenin	CHEBI:18186	1499	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Proline-rich_tyrosine_kinase_2 -LRB- Pyk2 -RRB- mediates vascular_endothelial-cadherin-based cell-cell adhesion by regulating beta-catenin tyrosine phosphorylation .
16489032	0	tyrosine	101,109	beta-catenin	129,141	tyrosine	beta-catenin	CHEBI:18186	1499	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	SKI-606 decreases growth and motility of colorectal_cancer cells by preventing pp60 -LRB- c-Src -RRB- - dependent tyrosine phosphorylation of beta-catenin and its nuclear signaling .
17851558	0	tyrosine	28,36	beta-catenin	15,27	tyrosine	beta-catenin	D014443	1499	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	FLT3 regulates beta-catenin tyrosine phosphorylation , nuclear localization , and transcriptional activity in acute_myeloid_leukemia cells .
17949810	0	tyrosine	14,22	beta-catenin	67,79	tyrosine	beta-catenin	CHEBI:18186	1499	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	KIT regulates tyrosine phosphorylation and nuclear localization of beta-catenin in mast_cell_leukemia .
20026641	0	tyrosine	64,72	beta-catenin	18,30	tyrosine	beta-catenin	CHEBI:18186	1499	Chemical	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification of beta-catenin as a target of the intracellular tyrosine kinase PTK6 .
20372837	0	tyrosine	39,47	beta-catenin	26,38	tyrosine	beta-catenin	CHEBI:18186	1499	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Collagen type I regulates beta-catenin tyrosine phosphorylation and nuclear translocation to promote migration and proliferation of gastric_carcinoma cells .
21541555	0	tyrosine	64,72	beta-catenin	92,104	tyrosine	beta-catenin	CHEBI:18186	1499	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Mutations of p53 , E-cadherin , alpha - _ and_beta-catenin genes and tyrosine phosphorylation of beta-catenin in human gastric_carcinomas .
23454381	0	tyrosine	91,99	beta1-adrenoceptor	119,137	tyrosine	beta1-adrenoceptor	CHEBI:18186	153	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Alpha1-adrenenoceptor stimulation inhibits cardiac excitation-contraction coupling through tyrosine phosphorylation of beta1-adrenoceptor .
11716783	0	tyrosine	93,101	beta1_integrin	142,156	tyrosine	beta1 integrin	CHEBI:18186	3688	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	The linkage between beta1_integrin and the actin cytoskeleton is differentially regulated by tyrosine and serine/threonine phosphorylation of beta1_integrin in normal and cancerous human breast cells .
14519852	0	tyrosine	43,51	beta3	28,33	tyrosine	beta3	CHEBI:18186	12297(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Soluble CD40_ligand induces beta3 integrin tyrosine phosphorylation and triggers platelet activation by outside-in signaling .
9593734	7	tyrosine	1200,1208	beta3	1194,1199	tyrosine	beta3	CHEBI:18186	1934	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Thus , our data indicate that platelet_aggregation is both necessary and sufficient for beta3 tyrosine phosphorylation , and this phosphorylation results in the physical linkage of alphaIIb beta3 to the cytoskeleton .
9812907	0	tyrosine	65,73	beta3	93,98	tyrosine	beta3	CHEBI:18186	1934	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Priming of platelet alphaIIbbeta3 by oxidants is associated with tyrosine phosphorylation of beta3 .
8581996	0	tyrosine	29,37	beta_1_and_beta_3_integrin	98,124	tyrosine	beta 1 and beta 3 integrin	CHEBI:18186	3688	Chemical	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Differential role of protein tyrosine phosphorylation/dephosphorylation in affinity regulation of beta_1_and_beta_3_integrin in human fibroblasts .
8521811	0	tyrosine	51,59	beta_2-adrenergic_receptor	118,144	tyrosine	beta 2-adrenergic receptor	CHEBI:18186	154	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Mutation of tyrosine-141 inhibits insulin-promoted tyrosine phosphorylation and increased responsiveness of the human beta_2-adrenergic_receptor .
9047385	0	tyrosine	49,57	biliary_glycoprotein	15,35	tyrosine	biliary glycoprotein	CHEBI:18186	26365(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Association Association|nmod|END_ENTITY	Association of biliary_glycoprotein with protein tyrosine phosphatase SHP-1 in malignant colon epithelial cells .
1537861	0	tyrosine	57,65	blk	78,81	tyrosine	blk	CHEBI:18186	12143(Tax:10090)	Chemical	Gene	regulation|nmod|START_ENTITY kinase|nsubj|regulation kinase|dobj|END_ENTITY	Structure and developmental regulation of the B-lymphoid tyrosine kinase gene blk .
2404338	0	tyrosine	25,33	blk	47,50	tyrosine	blk	CHEBI:18186	12143(Tax:10090)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Specific expression of a tyrosine kinase gene , blk , in B lymphoid cells .
7690139	0	tyrosine	43,51	blk	39,42	tyrosine	blk	CHEBI:18186	12143(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Antisense oligodeoxynucleotides to the blk tyrosine kinase prevent anti-mu-chain-mediated growth inhibition and apoptosis in a B-cell_lymphoma .
16155937	0	tyrosine	128,136	bone_morphogenetic_protein_type_II_receptor	75,118	tyrosine	bone morphogenetic protein type II receptor	CHEBI:18186	12168(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY END_ENTITY|nmod|receptor	Interaction and functional cooperation between the serine/threonine kinase bone_morphogenetic_protein_type_II_receptor with the tyrosine kinase stem_cell_factor receptor .
7686736	7	tyrosine	1076,1084	bradykinin	1104,1114	tyrosine	Bradykinin	CHEBI:18186	3827	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Stimulation of tyrosine kinase activity by bradykinin was concentration-dependent and resulted in the phosphorylation of three substrates of unknown identity .
10825163	0	tyrosine	17,25	brain-derived_neurotrophic_factor	61,94	tyrosine	brain-derived neurotrophic factor	CHEBI:18186	24225(Tax:10116)	Chemical	Gene	autophosphorylation|compound|START_ENTITY reduces|dobj|autophosphorylation reduces|nmod|/ /|compound|END_ENTITY	p75 reduces TrkB tyrosine autophosphorylation in response to brain-derived_neurotrophic_factor and neurotrophin_4 / 5 .
10833508	0	tyrosine	107,115	brain-derived_neurotrophic_factor	19,52	tyrosine	brain-derived neurotrophic factor	CHEBI:18186	627	Chemical	Gene	phosphorylation|amod|START_ENTITY inward|nmod|phosphorylation inhibits|ccomp|inward inhibits|nsubj|activation activation|nmod|END_ENTITY	TrkB activation by brain-derived_neurotrophic_factor inhibits the G protein-gated inward rectifier Kir3 by tyrosine phosphorylation of the channel .
1645620	0	tyrosine	103,111	brain-derived_neurotrophic_factor	25,58	tyrosine	brain-derived neurotrophic factor	CHEBI:18186	12064(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY ligands|nmod|receptor ligands|nsubj|factors factors|amod|END_ENTITY	The neurotrophic factors brain-derived_neurotrophic_factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor .
1649702	0	tyrosine	9,17	brain-derived_neurotrophic_factor	51,84	tyrosine	brain-derived neurotrophic factor	CHEBI:18186	12064(Tax:10090)	Chemical	Gene	kinase|amod|START_ENTITY receptor|nsubj|kinase receptor|nmod|END_ENTITY	The trkB tyrosine protein kinase is a receptor for brain-derived_neurotrophic_factor and neurotrophin-3 .
17286628	0	tyrosine	10,18	brain-derived_neurotrophic_factor	28,61	tyrosine	brain-derived neurotrophic factor	D014443	627	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|ccomp|directs directs|nsubj|receptor receptor|amod|END_ENTITY	Truncated tyrosine kinase B brain-derived_neurotrophic_factor receptor directs cortical neural_stem_cells to a glial cell fate by a novel signaling mechanism .
17391859	0	tyrosine	85,93	brain-derived_neurotrophic_factor	51,84	tyrosine	brain-derived neurotrophic factor	CHEBI:18186	24225(Tax:10116)	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Spatial memory training modifies the expression of brain-derived_neurotrophic_factor tyrosine kinase receptors in young and aged rats .
19285032	0	tyrosine	6,14	c-ABL	0,5	tyrosine	c-ABL	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	c-ABL tyrosine kinase stabilizes RAD51 chromatin association .
24177958	0	tyrosine	6,14	c-ABL	0,5	tyrosine	c-ABL	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	c-ABL tyrosine kinase modulates p53-dependent p21 induction and ensuing cell fate decision in response to DNA damage .
8943360	0	tyrosine	6,14	c-ABL	0,5	tyrosine	c-ABL	CHEBI:18186	25	Chemical	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	c-ABL tyrosine kinase activity is regulated by association with a novel SH3-domain-binding protein .
10022809	0	tyrosine	20,28	c-Abl	14,19	tyrosine	c-Abl	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Activation of c-Abl tyrosine kinase requires caspase activation and is not involved in JNK/SAPK activation during apoptosis of human monocytic_leukemia U937 cells .
10325413	0	tyrosine	38,46	c-Abl	32,37	tyrosine	c-Abl	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	The DNA-binding domain of human c-Abl tyrosine kinase promotes the interaction of a HMG chromosomal protein with DNA .
10625600	0	tyrosine	6,14	c-Abl	0,5	tyrosine	c-Abl	CHEBI:18186	395410(Tax:9031)	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	c-Abl tyrosine kinase is not essential for ataxia_telangiectasia_mutated functions in chromosomal maintenance .
10708759	0	tyrosine	76,84	c-Abl	93,98	tyrosine	c-Abl	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY interaction|nmod|kinase interaction|appos|END_ENTITY	Direct interaction of nerve_growth_factor_receptor , TrkA , with non-receptor tyrosine kinase , c-Abl , through the activation loop .
10837221	0	tyrosine	66,74	c-Abl	60,65	tyrosine	c-Abl	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Regulation of the hTERT telomerase catalytic subunit by the c-Abl tyrosine kinase .
10918577	0	tyrosine	10,18	c-Abl	4,9	tyrosine	c-Abl	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	The c-Abl tyrosine kinase contributes to the transient activation of MAP kinase in cells plated on fibronectin .
11120811	0	tyrosine	10,18	c-Abl	4,9	tyrosine	c-Abl	CHEBI:18186	11350(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	The c-Abl tyrosine kinase is regulated downstream of the B cell antigen receptor and interacts with CD19 .
11390389	0	tyrosine	6,14	c-Abl	0,5	tyrosine	c-Abl	CHEBI:18186	11350(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	c-Abl tyrosine kinase binds and phosphorylates phospholipid_scramblase_1 .
11781820	0	tyrosine	130,138	c-Abl	124,129	tyrosine	c-Abl	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Phosphorylation and structure-based functional studies reveal a positive and a negative role for the activation loop of the c-Abl tyrosine kinase .
11971963	0	tyrosine	6,14	c-Abl	0,5	tyrosine	c-Abl	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage .
12824179	0	tyrosine	6,14	c-Abl	0,5	tyrosine	c-Abl	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	c-Abl tyrosine kinase selectively regulates p73 nuclear matrix association .
15031292	0	tyrosine	10,18	c-Abl	4,9	tyrosine	c-Abl	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	The c-Abl tyrosine kinase phosphorylates the Fe65 adaptor protein to stimulate Fe65/amyloid _ precursor_protein nuclear signaling .
15448168	0	tyrosine	52,60	c-Abl	46,51	tyrosine	c-Abl	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Phosphorylation of DNA topoisomerase I by the c-Abl tyrosine kinase confers camptothecin sensitivity .
15657060	0	tyrosine	6,14	c-Abl	0,5	tyrosine	c-Abl	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	c-Abl tyrosine kinase regulates caspase-9 autocleavage in the apoptotic response to DNA damage .
15850559	0	tyrosine	6,14	c-Abl	0,5	tyrosine	c-Abl	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	c-Abl tyrosine kinase regulates c-fos gene expression via phosphorylating RNA polymerase II .
17339230	0	tyrosine	6,14	c-Abl	0,5	tyrosine	c-Abl	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	c-Abl tyrosine kinase activates p21 transcription via interaction with p53 .
17341836	0	tyrosine	85,93	c-Abl	79,84	tyrosine	c-Abl	CHEBI:18186	25	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Screening of drugs that suppress Ste11 MAPKKK activation in yeast identified a c-Abl tyrosine kinase inhibitor .
17626041	0	tyrosine	74,82	c-Abl	68,73	tyrosine	c-Abl	D014443	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Cockayne_syndrome protein B interacts with and is phosphorylated by c-Abl tyrosine kinase .
17893873	0	tyrosine	46,54	c-Abl	0,5	tyrosine	c-Abl	CHEBI:18186	25	Chemical	Gene	activity|amod|START_ENTITY MAPK|nmod|activity MAPK|amod|END_ENTITY	c-Abl activates p38 MAPK independently of its tyrosine kinase activity : Implications in cisplatin-based therapy .
18305217	0	tyrosine	10,18	c-Abl	4,9	tyrosine	c-Abl	CHEBI:18186	11350(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	The c-Abl tyrosine kinase regulates actin remodeling at the immune synapse .
19098427	0	tyrosine	48,56	c-Abl	42,47	tyrosine	c-Abl	CHEBI:18186	11350(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	T cell survival and function requires the c-Abl tyrosine kinase .
19156526	0	tyrosine	54,62	c-Abl	48,53	tyrosine	c-Abl	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Proliferating_cell_nuclear_antigen destabilizes c-Abl tyrosine kinase and regulates cell apoptosis in response to DNA damage .
19914245	0	tyrosine	6,14	c-Abl	0,5	tyrosine	c-Abl	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	c-Abl tyrosine kinase interacts with MAVS and regulates innate immune response .
20080568	0	tyrosine	6,14	c-Abl	0,5	tyrosine	c-Abl	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	c-Abl tyrosine kinase regulates cardiac growth and development .
20563669	0	tyrosine	10,18	c-Abl	4,9	tyrosine	c-Abl	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	The c-Abl tyrosine kinase stabilizes Pitx1 in the apoptotic response to DNA damage .
20823226	0	tyrosine	37,45	c-Abl	23,28	tyrosine	c-Abl	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin 's ubiquitination and protective function .
21321929	0	tyrosine	10,18	c-Abl	4,9	tyrosine	c-Abl	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	The c-Abl tyrosine kinase controls protein_kinase_C - induced Fli-1 phosphorylation in human dermal fibroblasts .
22199356	0	tyrosine	6,14	c-Abl	0,5	tyrosine	c-Abl	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	c-Abl tyrosine kinase regulates serum-induced nuclear export of diacylglycerol_kinase_a by phosphorylation at Tyr-218 .
23325923	0	tyrosine	6,14	c-Abl	0,5	tyrosine	c-Abl	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	c-Abl tyrosine kinase plays a critical role in b2 integrin-dependent neutrophil migration by regulating Vav1 activity .
23928308	0	tyrosine	78,86	c-Abl	72,77	tyrosine	c-Abl	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Intramolecular dynamics within the N-Cap-SH3-SH2 regulatory unit of the c-Abl tyrosine kinase reveal targeting to the cellular membrane .
24392933	0	tyrosine	6,14	c-Abl	0,5	tyrosine	c-Abl	D014443	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	c-Abl tyrosine kinase regulates cytokinesis of human airway smooth muscle cells .
24401847	0	tyrosine	112,120	c-Abl	106,111	tyrosine	c-Abl	D014443	11350(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Protein kinase G increases antioxidant function in lung microvascular endothelial cells by inhibiting the c-Abl tyrosine kinase .
25368164	0	tyrosine	6,14	c-Abl	0,5	tyrosine	c-Abl	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	c-Abl tyrosine kinase promotes adipocyte differentiation by targeting PPAR-gamma 2 .
25795725	0	tyrosine	15,23	c-Abl	0,5	tyrosine	c-Abl	D014443	25	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	c-Abl mediated tyrosine phosphorylation of paxillin regulates LPS-induced endothelial_dysfunction and lung_injury .
7590236	0	tyrosine	63,71	c-Abl	57,62	tyrosine	c-Abl	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Abi-2 , a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity .
7682703	0	tyrosine	115,123	c-Abl	101,106	tyrosine	c-Abl	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	En bloc substitution of the Src homology region 2 domain activates the transforming potential of the c-Abl protein tyrosine kinase .
8242749	0	tyrosine	90,98	c-Abl	84,89	tyrosine	c-Abl	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	A C-terminal protein-binding domain in the retinoblastoma_protein regulates nuclear c-Abl tyrosine kinase in the cell cycle .
8294516	0	tyrosine	31,39	c-Abl	25,30	tyrosine	c-Abl	CHEBI:18186	11350(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	The COOH terminus of the c-Abl tyrosine kinase contains distinct F - and G-actin binding domains with bundling activity .
8900110	0	tyrosine	48,56	c-Abl	42,47	tyrosine	c-Abl	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Genotoxic drugs induce interaction of the c-Abl tyrosine kinase and the tumor suppressor protein p53 .
9037071	0	tyrosine	56,64	c-Abl	50,55	tyrosine	c-Abl	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase .
9168116	0	tyrosine	53,61	c-Abl	47,52	tyrosine	c-Abl	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Ataxia_telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation .
9334312	0	tyrosine	145,153	c-Abl	139,144	tyrosine	c-Abl	CHEBI:18186	11350(Tax:10090)	Chemical	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	The PAG gene product , a stress-induced protein with antioxidant properties , is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity .
9558345	0	tyrosine	42,50	c-Abl	36,41	tyrosine	c-Abl	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	The DNA binding domain of the human c-Abl tyrosine kinase preferentially binds to DNA sequences containing an AAC motif and to distorted DNA structures .
9583675	0	tyrosine	30,38	c-Abl	24,29	tyrosine	c-Abl	CHEBI:18186	11350(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Functional role for the c-Abl tyrosine kinase in meiosis I .
9704921	0	tyrosine	6,14	c-Abl	0,5	tyrosine	c-Abl	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	c-Abl tyrosine kinase can mediate tumor cell apoptosis independently of the Rb and p53 tumor suppressors .
22378924	0	tyrosine	65,73	c-Abl1	58,64	tyrosine	c-Abl1	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Productive replication of Ebola_virus is regulated by the c-Abl1 tyrosine kinase .
10514377	0	tyrosine	4,12	c-Cbl	39,44	tyrosine	c-Cbl	CHEBI:18186	867	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|dobj|END_ENTITY	The tyrosine kinase negative regulator c-Cbl as a RING-type , E2-dependent ubiquitin-protein ligase .
10521482	1	tyrosine	89,97	c-Cbl	81,86	tyrosine	c-Cbl	CHEBI:18186	867	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod:poss|END_ENTITY	A role in c-Cbl 's tyrosine phosphorylation and its association with epidermal_growth_factor_receptor .
11997497	0	tyrosine	22,30	c-Cbl	16,21	tyrosine	c-Cbl	CHEBI:18186	12402(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	APS facilitates c-Cbl tyrosine phosphorylation and GLUT4 translocation in response to insulin in 3T3-L1 adipocytes .
15117950	1	tyrosine	206,214	c-Cbl	176,181	tyrosine	c-Cbl	CHEBI:18186	867	Chemical	Gene	START_ENTITY|nsubj|receptor receptor|amod|END_ENTITY	c-Cbl down-regulates receptor tyrosine kinases by conjugating ubiquitin to them , leading to receptor internalization and degradation .
18663086	0	tyrosine	21,29	c-Cbl	15,20	tyrosine	c-Cbl	CHEBI:18186	500985(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Suppression of c-Cbl tyrosine phosphorylation inhibits neointimal formation in balloon-injured rat arteries .
8900205	0	tyrosine	63,71	c-Cbl	48,53	tyrosine	c-Cbl	CHEBI:18186	867	Chemical	Gene	START_ENTITY|nsubj|association association|nmod|END_ENTITY	Specific association of tyrosine-phosphorylated c-Cbl with Fyn tyrosine kinase in T cells .
9845379	0	tyrosine	6,14	c-Cbl	0,5	tyrosine	c-Cbl	CHEBI:18186	867	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	c-Cbl tyrosine phosphorylation and subcellular localization in human primary leukemic cells .
7534289	0	tyrosine	40,48	c-Crk	79,84	tyrosine	c-Crk	CHEBI:18186	12928(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Insulin-like growth factor-I stimulates tyrosine phosphorylation of endogenous c-Crk .
17160021	0	tyrosine	17,25	c-Fos	11,16	tyrosine	c-Fos	CHEBI:18186	2353	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	N-Terminal c-Fos tyrosine phosphorylation regulates c-Fos/ER association and c-Fos-dependent phospholipid synthesis activation .
22105363	0	tyrosine	70,78	c-Fos	64,69	tyrosine	c-Fos	CHEBI:18186	2353	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	The kinase c-Src and the phosphatase TC45 coordinately regulate c-Fos tyrosine phosphorylation and c-Fos phospholipid synthesis activation capacity .
15723656	4	tyrosine	726,734	c-KIT	754,759	tyrosine	c-KIT	CHEBI:18186	3815	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Geldanamycin , an inhibitor of Hsp90 , also prevents interaction between c-KIT and Hsp90 , and inhibits tyrosine phosphorylation of c-KIT .
15790786	0	tyrosine	88,96	c-KIT	30,35	tyrosine	c-KIT	CHEBI:18186	3815	Chemical	Gene	PKC412|amod|START_ENTITY sensitive|nmod|PKC412 sensitive|nsubj|mutations mutations|nmod|END_ENTITY	Activation mutations of human c-KIT resistant to imatinib_mesylate are sensitive to the tyrosine kinase inhibitor PKC412 .
16840725	0	tyrosine	32,40	c-KIT	17,22	tyrosine	c-KIT	CHEBI:18186	3815	Chemical	Gene	START_ENTITY|nsubj|receptor receptor|amod|END_ENTITY	Newly identified c-KIT receptor tyrosine kinase ITD in childhood AML induces ligand-independent growth and is responsive to a synergistic effect of imatinib and rapamycin .
19283847	0	tyrosine	9,17	c-KIT	89,94	tyrosine	c-KIT	CHEBI:18186	3815	Chemical	Gene	kinases|compound|START_ENTITY kinases|dep|evaluation evaluation|nmod|END_ENTITY	Receptor tyrosine kinases in sinonasal_undifferentiated_carcinomas -- evaluation for EGFR , c-KIT , and HER2/neu expression .
25025175	0	tyrosine	19,27	c-KIT	36,41	tyrosine	c-KIT	CHEBI:18186	3815	Chemical	Gene	kinases|nsubj|START_ENTITY kinases|ccomp|show show|nsubj|END_ENTITY	The three receptor tyrosine kinases c-KIT , VEGFR2 and PDGFRa , closely spaced at 4q12 , show increased protein expression in triple-negative breast_cancer .
11018522	0	tyrosine	127,135	c-Kit	94,99	tyrosine	c-Kit	CHEBI:18186	3815	Chemical	Gene	activity|amod|START_ENTITY regulated|nmod|activity regulated|nsubjpass|association association|nmod|multiple_PDZ_domain_containing_proteins multiple_PDZ_domain_containing_proteins|nmod|C-terminus C-terminus|amod|END_ENTITY	The direct association of the multiple_PDZ_domain_containing_proteins -LRB- MUPP-1 -RRB- with the human c-Kit C-terminus is regulated by tyrosine kinase activity .
11964302	0	tyrosine	24,32	c-Kit	18,23	tyrosine	c-Kit	CHEBI:18186	3815	Chemical	Gene	START_ENTITY|nsubj|roles roles|nmod|END_ENTITY	Critical roles of c-Kit tyrosine residues 567 and 719 in stem_cell_factor-induced chemotaxis : contribution of src family kinase and PI3-kinase on calcium mobilization and cell migration .
12354381	1	tyrosine	119,127	c-Kit	142,147	tyrosine	c-Kit	CHEBI:18186	16590(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|c-Kit c-Kit|dep|END_ENTITY	Mice lacking the receptor tyrosine kinase c-Kit -LRB- c-Kit -LRB- W/W -RRB- -RRB- have hematopoietic_defects causing perinatal death .
15039213	0	tyrosine	44,52	c-Kit	38,43	tyrosine	c-Kit	CHEBI:18186	3815	Chemical	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Expression of a truncated form of the c-Kit tyrosine kinase receptor and activation of Src kinase in human prostatic_cancer .
16190746	0	tyrosine	122,130	c-Kit	42,47	tyrosine	c-Kit	CHEBI:18186	3815	Chemical	Gene	kinases|amod|START_ENTITY derivatives|nmod|kinases ATP-competitive|nmod|derivatives based|nmod|ATP-competitive based|nsubj|modeling modeling|nmod|inhibition inhibition|compound|END_ENTITY	Molecular modeling of wild-type and D816V c-Kit inhibition based on ATP-competitive binding of ellipticine derivatives to tyrosine kinases .
17350321	0	tyrosine	47,55	c-Kit	0,5	tyrosine	c-Kit	CHEBI:18186	3815	Chemical	Gene	kinase|compound|START_ENTITY cell|dep|kinase END_ENTITY|dep|cell	c-Kit -- a hematopoietic cell essential receptor tyrosine kinase .
17519280	0	tyrosine	29,37	c-Kit	14,19	tyrosine	c-Kit	CHEBI:18186	3815	Chemical	Gene	START_ENTITY|nsubj|Expression Expression|nmod|receptor receptor|amod|END_ENTITY	Expression of c-Kit receptor tyrosine kinase and effect on beta-cell development in the human fetal pancreas .
17876336	0	tyrosine	72,80	c-Kit	66,71	tyrosine	c-Kit	CHEBI:18186	3815	Chemical	Gene	kinases|compound|START_ENTITY kinases|amod|END_ENTITY	Carcinoma of an unknown primary : are EGF receptor , Her-2 / neu , and c-Kit tyrosine kinases potential targets for therapy ?
19892442	0	tyrosine	61,69	c-Kit	46,51	tyrosine	c-Kit	CHEBI:18186	3815	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|amod|END_ENTITY	Three dimensional pharmacophore modelling for c-Kit receptor tyrosine kinase inhibitors .
20147452	0	tyrosine	28,36	c-Kit	73,78	tyrosine	c-Kit	CHEBI:18186	3815	Chemical	Gene	START_ENTITY|nmod|mechanism mechanism|nmod|auto-activation auto-activation|amod|END_ENTITY	Function of activation loop tyrosine phosphorylation in the mechanism of c-Kit auto-activation and its implication in sunitinib resistance .
20200353	0	tyrosine	13,21	c-Kit	29,34	tyrosine	c-Kit	CHEBI:18186	3815	Chemical	Gene	START_ENTITY|dobj|receptor receptor|amod|END_ENTITY	The receptor tyrosine kinase c-Kit controls IL-33 receptor signaling in mast cells .
20205869	0	tyrosine	78,86	c-Kit	54,59	tyrosine	c-Kit	CHEBI:18186	3815	Chemical	Gene	Shp-2|amod|START_ENTITY interaction|nmod|Shp-2 receptor|acl|interaction receptor|appos|END_ENTITY	The structural insights of stem cell factor receptor -LRB- c-Kit -RRB- interaction with tyrosine phosphatase-2 -LRB- Shp-2 -RRB- : an in silico analysis .
21057534	0	tyrosine	87,95	c-Kit	40,45	tyrosine	c-Kit	CHEBI:18186	3815	Chemical	Gene	inhibitors|amod|START_ENTITY off-target|nmod|inhibitors cells|nmod|off-target and|dep|cells and|dep|roles roles|nmod|END_ENTITY	Tumor-intrinsic and - extrinsic roles of c-Kit : mast cells as the primary off-target of tyrosine kinase inhibitors .
22324351	0	tyrosine	109,117	c-Kit	103,108	tyrosine	c-Kit	CHEBI:18186	3815	Chemical	Gene	kinase|amod|START_ENTITY inhibitor|amod|kinase inhibitor|amod|END_ENTITY	Mast_cell_leukemia : identification of a new c-Kit mutation , dup -LRB- 501-502 -RRB- , and response to masitinib , a c-Kit tyrosine kinase inhibitor .
22324351	0	tyrosine	109,117	c-Kit	44,49	tyrosine	c-Kit	CHEBI:18186	3815	Chemical	Gene	kinase|amod|START_ENTITY inhibitor|amod|kinase Mast_cell_leukemia|appos|inhibitor Mast_cell_leukemia|dep|identification identification|nmod|mutation mutation|amod|END_ENTITY	Mast_cell_leukemia : identification of a new c-Kit mutation , dup -LRB- 501-502 -RRB- , and response to masitinib , a c-Kit tyrosine kinase inhibitor .
23803604	0	tyrosine	39,47	c-Kit	55,60	tyrosine	c-Kit	CHEBI:18186	3815	Chemical	Gene	START_ENTITY|ccomp|crucial crucial|nsubj|823 823|nmod|END_ENTITY	Phosphorylation of the activation loop tyrosine 823 in c-Kit is crucial for cell survival and proliferation .
25425690	0	tyrosine	23,31	c-Kit	14,19	tyrosine	c-Kit	CHEBI:18186	3815	Chemical	Gene	inhibitors|amod|START_ENTITY Inhibition|nmod|inhibitors Inhibition|nmod|END_ENTITY	Inhibition of c-Kit by tyrosine kinase inhibitors .
25435369	0	tyrosine	20,28	c-Kit	83,88	tyrosine	c-Kit	CHEBI:18186	16590(Tax:10090)	Chemical	Gene	loop|amod|START_ENTITY essential|nsubj|loop essential|nmod|capacity capacity|nmod|D816V D816V|amod|END_ENTITY	The activation loop tyrosine 823 is essential for the transforming capacity of the c-Kit oncogenic mutant D816V .
25510664	0	tyrosine	28,36	c-Kit	112,117	tyrosine	c-Kit	CHEBI:18186	3815	Chemical	Gene	inhibitor|amod|START_ENTITY resistance|nmod|inhibitor mediated|nsubjpass|resistance mediated|nmod|transduction transduction|amod|END_ENTITY	Acquired resistance to EGFR tyrosine kinase inhibitor in A431_squamous_cell_carcinoma xenografts is mediated by c-Kit pathway transduction .
25643653	0	tyrosine	78,86	c-Kit	63,68	tyrosine	c-Kit	CHEBI:18186	3815	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	A survival Kit for pancreatic beta cells : stem_cell_factor and c-Kit receptor tyrosine kinase .
7545021	0	tyrosine	68,76	c-Kit	125,130	tyrosine	c-Kit	CHEBI:18186	3815	Chemical	Gene	ligand|amod|START_ENTITY ligand|nmod|+ +|appos|cells cells|amod|END_ENTITY	Expression and physiologic significance of Kit ligand and stem cell tyrosine kinase-1 receptor ligand in normal human CD34 + , c-Kit + marrow cells .
9064328	0	tyrosine	104,112	c-Kit	83,88	tyrosine	c-Kit	CHEBI:18186	16590(Tax:10090)	Chemical	Gene	SHP1|compound|START_ENTITY reveals|nmod|SHP1 reveals|dobj|regulation regulation|nmod|END_ENTITY	Genetic analysis reveals cell type-specific regulation of receptor tyrosine kinase c-Kit by the protein tyrosine phosphatase SHP1 .
9464535	0	tyrosine	59,67	c-Kit	44,49	tyrosine	c-Kit	CHEBI:18186	16590(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Transformation of NIH3T3 fibroblasts by the c-Kit receptor tyrosine kinase : effect of receptor density and ligand-requirement .
9528781	0	tyrosine	76,84	c-Kit	41,46	tyrosine	c-Kit	CHEBI:18186	16590(Tax:10090)	Chemical	Gene	interaction|nmod|START_ENTITY modulates|nmod|interaction modulates|dobj|receptor receptor|amod|END_ENTITY	SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain .
9528781	0	tyrosine	76,84	c-Kit	96,101	tyrosine	c-Kit	CHEBI:18186	16590(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|domain domain|amod|END_ENTITY	SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain .
9931308	0	tyrosine	67,75	c-Kit	53,58	tyrosine	c-Kit	CHEBI:18186	3815	Chemical	Gene	domain|compound|START_ENTITY domain|amod|END_ENTITY	A transforming mutation enhances the activity of the c-Kit soluble tyrosine kinase domain .
16982759	0	tyrosine	105,113	c-MET	130,135	tyrosine	c-MET	CHEBI:18186	4233	Chemical	Gene	START_ENTITY|dobj|kinase kinase|appos|member member|amod|END_ENTITY	Therapeutic implications of a human neutralizing antibody to the macrophage-stimulating_protein receptor tyrosine kinase -LRB- RON -RRB- , a c-MET family member .
23484006	0	tyrosine	92,100	c-MET	126,131	tyrosine	c-MET	CHEBI:18186	4233	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|nmod|END_ENTITY	Effects of dual targeting of tumor cells and stroma in human glioblastoma xenografts with a tyrosine kinase inhibitor against c-MET and VEGFR2 .
24827412	1	tyrosine	125,133	c-MET	110,115	tyrosine	c-MET	CHEBI:18186	4233	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	The c-MET receptor tyrosine kinase is the receptor for hepatocyte growth factor .
11745410	0	tyrosine	101,109	c-Met	129,134	tyrosine	c-Met	CHEBI:18186	4233	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Ganglioside GD1a inhibits HGF-induced motility and scattering of cancer cells through suppression of tyrosine phosphorylation of c-Met .
12594808	0	tyrosine	138,146	c-Met	34,39	tyrosine	c-Met	CHEBI:18186	4233	Chemical	Gene	START_ENTITY|nsubj|expression expression|amod|END_ENTITY	Radiation stimulates HGF_receptor / c-Met expression that leads to amplifying cellular response to HGF stimulation via upregulated receptor tyrosine phosphorylation and MAP kinase activity in pancreatic_cancer cells .
14559966	0	tyrosine	25,33	c-Met	89,94	tyrosine	c-Met	CHEBI:18186	4233	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a .
15735664	0	tyrosine	86,94	c-Met	67,72	tyrosine	c-Met	CHEBI:18186	403438(Tax:9615)	Chemical	Gene	residue|compound|START_ENTITY END_ENTITY|nmod|residue	The SH2-domian-containing inositol 5-phosphatase -LRB- SHIP -RRB- -2 binds to c-Met directly via tyrosine residue 1356 and involves hepatocyte_growth_factor -LRB- HGF -RRB- - induced lamellipodium formation , cell scattering and cell spreading .
19199866	0	tyrosine	65,73	c-Met	42,47	tyrosine	c-Met	CHEBI:18186	4233	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	From concept to reality : the long road to c-Met and RON receptor tyrosine kinase inhibitors for the treatment of cancer .
19423004	0	tyrosine	127,135	c-Met	112,117	tyrosine	c-Met	CHEBI:18186	17295(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|SPECT SPECT|nmod|peptide peptide|nmod|mice mice|acl|bearing bearing|dobj|receptor receptor|amod|END_ENTITY	Characterization , biodistribution and small-animal SPECT of I-125-labeled c-Met binding peptide in mice bearing c-Met receptor tyrosine kinase-positive tumor xenografts .
19423004	0	tyrosine	127,135	c-Met	74,79	tyrosine	c-Met	CHEBI:18186	17295(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|SPECT SPECT|nmod|peptide peptide|compound|END_ENTITY	Characterization , biodistribution and small-animal SPECT of I-125-labeled c-Met binding peptide in mice bearing c-Met receptor tyrosine kinase-positive tumor xenografts .
19459657	0	tyrosine	45,53	c-Met	30,35	tyrosine	c-Met	CHEBI:18186	4233	Chemical	Gene	START_ENTITY|nsubj|characterization characterization|nmod|receptor receptor|amod|END_ENTITY	Enzymatic characterization of c-Met receptor tyrosine kinase oncogenic mutants and kinetic studies with aminopyridine and triazolopyrazine inhibitors .
19939254	1	tyrosine	183,191	c-Met	172,177	tyrosine	C-Met	CHEBI:18186	4233	Chemical	Gene	receptor|amod|START_ENTITY receptor|nsubj|END_ENTITY	BACKGROUND : c-Met is a tyrosine kinase receptor for hepatocyte growth factor/scatter factor -LRB- HGF/SF -RRB- , and both c-Met and its ligand are expressed in a variety of tissues .
20028557	0	tyrosine	19,27	c-Met	4,9	tyrosine	c-Met	CHEBI:18186	4233	Chemical	Gene	MP470|amod|START_ENTITY MP470|amod|END_ENTITY	The c-Met receptor tyrosine kinase inhibitor MP470 radiosensitizes glioblastoma cells .
20647329	0	tyrosine	37,45	c-Met	172,177	tyrosine	c-Met	CHEBI:18186	4233	Chemical	Gene	inhibitor|compound|START_ENTITY combination|nmod|inhibitor overcomes|nsubj|combination overcomes|nmod|inhibition inhibition|amod|END_ENTITY	The combination of multiple receptor tyrosine kinase inhibitor and mammalian_target_of_rapamycin inhibitor overcomes erlotinib resistance in lung_cancer cell lines through c-Met inhibition .
21163258	0	tyrosine	45,53	c-Met	61,66	tyrosine	c-Met	CHEBI:18186	4233	Chemical	Gene	START_ENTITY|nmod|sequence sequence|amod|END_ENTITY	An adjacent arginine , and the phosphorylated tyrosine in the c-Met receptor target sequence , dictates the orientation of c-Cbl binding .
22985853	0	tyrosine	87,95	c-Met	103,108	tyrosine	c-Met	CHEBI:18186	4233	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Multisubstituted quinoxalines and pyrido -LSB- 2,3-d -RSB- pyrimidines : synthesis and SAR study as tyrosine kinase c-Met inhibitors .
23548264	0	tyrosine	45,53	c-Met	21,26	tyrosine	c-Met	CHEBI:18186	4233	Chemical	Gene	START_ENTITY|nsubj|inhibitor inhibitor|nmod|receptor receptor|amod|END_ENTITY	A novel inhibitor of c-Met and VEGF receptor tyrosine kinases with a broad spectrum of in vivo antitumor activities .
23624790	0	tyrosine	52,60	c-Met	46,51	tyrosine	c-Met	CHEBI:18186	4233	Chemical	Gene	1003|compound|START_ENTITY 1003|amod|END_ENTITY	Lipopolysaccharide-induced phosphorylation of c-Met tyrosine residue 1003 regulates c-Met intracellular trafficking and lung epithelial barrier function .
23624790	0	tyrosine	52,60	c-Met	84,89	tyrosine	c-Met	CHEBI:18186	4233	Chemical	Gene	1003|compound|START_ENTITY phosphorylation|nmod|1003 regulates|nsubj|phosphorylation regulates|dobj|trafficking trafficking|amod|END_ENTITY	Lipopolysaccharide-induced phosphorylation of c-Met tyrosine residue 1003 regulates c-Met intracellular trafficking and lung epithelial barrier function .
23973484	0	tyrosine	96,104	c-Met	112,117	tyrosine	c-Met	CHEBI:18186	17295(Tax:10090)	Chemical	Gene	regulating|dobj|START_ENTITY vitro|advcl|regulating END_ENTITY|amod|vitro	6-Phosphogluconate dehydrogenase regulates tumor cell migration in vitro by regulating receptor tyrosine kinase c-Met .
26698536	0	tyrosine	100,108	c-Met	94,99	tyrosine	c-Met	D014443	17295(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Pyridazinone derivatives displaying highly potent and selective inhibitory activities against c-Met tyrosine kinase .
7515877	0	tyrosine	25,33	c-Met	79,84	tyrosine	c-Met	CHEBI:18186	17295(Tax:10090)	Chemical	Gene	site|amod|START_ENTITY role|nmod|site role|nmod|receptor receptor|amod|END_ENTITY	Regulatory role of major tyrosine autophosphorylation site of kinase domain of c-Met receptor -LRB- scatter_factor / hepatocyte growth factor receptor -RRB- .
9524770	0	tyrosine	52,60	c-Met	46,51	tyrosine	c-Met	CHEBI:18186	17295(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	The functions of HGF/SF and its receptor , the c-Met tyrosine kinase , in mammalian development .
9722511	0	tyrosine	133,141	c-Met	86,91	tyrosine	c-Met	CHEBI:18186	4233	Chemical	Gene	phosphorylation|compound|START_ENTITY confers|dobj|phosphorylation confers|nsubj|interaction interaction|nmod|alpha alpha|nmod|hepatocyte_growth_factor hepatocyte_growth_factor|nmod|receptor receptor|amod|END_ENTITY	Cooperative interaction between alpha - and beta-chains of hepatocyte_growth_factor on c-Met receptor confers ligand-induced receptor tyrosine phosphorylation and multiple biological responses .
20422010	6	tyrosine	1257,1265	c-RET	1251,1256	tyrosine	c-RET	CHEBI:18186	19713(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	We next showed c-RET and GFRa1 protein expression in HM3KO cells and GDNF-mediated increased levels of their phosphorylated c-RET tyrosine kinase and signal transduction molecules -LRB- ERK and AKT -RRB- sited potentially downstream of c-RET .
26807966	0	tyrosine	14,22	c-SRC	0,5	tyrosine	c-SRC	D014443	6714	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	c-SRC protein tyrosine kinase regulates early HIV-1_infection post-entry .
11545730	0	tyrosine	120,128	c-Src	107,112	tyrosine	c-Src	CHEBI:18186	6714	Chemical	Gene	kinases|compound|START_ENTITY kinases|amod|END_ENTITY	Progesterone_receptor contains a proline-rich motif that directly interacts with SH3 domains and activates c-Src family tyrosine kinases .
12692900	0	tyrosine	14,22	c-Src	0,5	tyrosine	c-Src	CHEBI:18186	83805(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|protein protein|amod|END_ENTITY	c-Src protein tyrosine kinase activity is required for muscarinic receptor-mediated DNA synthesis and neurogenesis via ERK1/2 and c-AMP-responsive element-binding protein signaling in neural precursor cells .
12821181	0	tyrosine	67,75	c-Src	91,96	tyrosine	c-Src	CHEBI:18186	83805(Tax:10116)	Chemical	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	Free radicals are involved in continuous activation of nonreceptor tyrosine protein kinase c-Src after ischemia/reperfusion in rat hippocampus .
14761189	0	tyrosine	101,109	c-Src	127,132	tyrosine	c-Src	CHEBI:18186	6714	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Discovery of a new class of anilinoquinazoline inhibitors with high affinity and specificity for the tyrosine kinase domain of c-Src .
16260764	0	tyrosine	58,66	c-Src	52,57	tyrosine	c-Src	CHEBI:18186	6714	Chemical	Gene	kinases|compound|START_ENTITY kinases|amod|END_ENTITY	High yield bacterial expression of active c-Abl and c-Src tyrosine kinases .
17978100	0	tyrosine	4,12	c-Src	32,37	tyrosine	c-Src	CHEBI:18186	6714	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	The tyrosine kinase activity of c-Src regulates actin dynamics and organization of podosomes in osteoclasts .
18524994	0	tyrosine	34,42	c-Src	28,33	tyrosine	c-Src	CHEBI:18186	6714	Chemical	Gene	kinases|compound|START_ENTITY kinases|amod|END_ENTITY	Validation of PDGFRbeta and c-Src tyrosine kinases as tumor/vessel targets in patients with multiple_myeloma : preclinical efficacy of the novel , orally available inhibitor dasatinib .
24413044	0	tyrosine	23,31	c-Src	0,5	tyrosine	c-Src	CHEBI:18186	6714	Chemical	Gene	kinases|compound|START_ENTITY kinases|amod|END_ENTITY	c-Src and Pyk2 protein tyrosine kinases play protective roles in early HIV-1_infection of CD4 + T-cell lines .
25501895	0	tyrosine	15,23	c-Src	0,5	tyrosine	c-Src	CHEBI:18186	6714	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	c-Src mediated tyrosine phosphorylation of plakophilin_3 as a new mechanism to control desmosome composition in cells exposed to oxidative stress .
9388274	0	tyrosine	27,35	c-Src	21,26	tyrosine	c-Src	CHEBI:18186	6714	Chemical	Gene	kinases|compound|START_ENTITY kinases|amod|END_ENTITY	Heat_shock activates c-Src tyrosine kinases and phosphatidylinositol 3-kinase in NIH3T3 fibroblasts .
9882612	0	tyrosine	176,184	c-Src	170,175	tyrosine	c-Src	CHEBI:18186	6714	Chemical	Gene	kinases|compound|START_ENTITY kinases|amod|END_ENTITY	Platelet-derived-growth-factor stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle : role of pertussis-toxin-sensitive G-proteins , c-Src tyrosine kinases and phosphoinositide_3-kinase .
15674841	0	tyrosine	56,64	c-Src_kinase	106,118	tyrosine	c-Src kinase	CHEBI:18186	1445	Chemical	Gene	START_ENTITY|dobj|activities activities|amod|END_ENTITY	Studies on the mechanism of rapid activation of protein tyrosine phosphorylation activities , particularly c-Src_kinase , by TCDD in MCF10A .
11950934	0	tyrosine	12,20	c-Yes	28,33	tyrosine	c-Yes	CHEBI:18186	7525	Chemical	Gene	START_ENTITY|dobj|interacts interacts|amod|END_ENTITY	Nonreceptor tyrosine kinase c-Yes interacts with occludin during tight junction formation in canine kidney epithelial cells .
16930953	0	tyrosine	121,129	c-Yes	115,120	tyrosine	c-Yes	CHEBI:18186	7525	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Verotoxin-1 stimulation of macrophage-like THP-1 cells up-regulates tissue factor expression through activation of c-Yes tyrosine kinase : Possible signal transduction in tissue factor up-regulation .
17418139	0	tyrosine	64,72	c-Yes	58,63	tyrosine	c-Yes	CHEBI:18186	7525	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Crystallographic structure of the SH3 domain of the human c-Yes tyrosine kinase : loop flexibility and amyloid_aggregation .
21390316	0	tyrosine	46,54	c-Yes	62,67	tyrosine	c-Yes	CHEBI:18186	7525	Chemical	Gene	activity|nmod|START_ENTITY kinase|nsubj|activity kinase|dobj|END_ENTITY	Specific oncogenic activity of the Src-family tyrosine kinase c-Yes in colon_carcinoma cells .
7690926	0	tyrosine	31,39	c-Yes	47,52	tyrosine	c-Yes	CHEBI:18186	7525	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Elevated expression of protein tyrosine kinase c-Yes , but not c-Src , in human malignant_melanoma .
9681823	0	tyrosine	27,35	c-Yes	43,48	tyrosine	c-Yes	CHEBI:18186	7525	Chemical	Gene	Stimulation|nmod|START_ENTITY kinase|nsubj|Stimulation kinase|xcomp|c-Src c-Src|dep|END_ENTITY	Stimulation of the protein tyrosine kinase c-Yes but not c-Src by neurotrophins in human brain-metastatic melanoma cells .
2496972	0	tyrosine	57,65	c-abl	51,56	tyrosine	c-abl	CHEBI:18186	11350(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Deletion of an N-terminal regulatory domain of the c-abl tyrosine kinase activates its oncogenic potential .
3879812	0	tyrosine	19,27	c-abl	13,18	tyrosine	c-abl	CHEBI:18186	25	Chemical	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Detection of c-abl tyrosine kinase activity in vitro permits direct comparison of normal and altered abl gene products .
17121910	0	tyrosine	8,16	c-fms	2,7	tyrosine	c-fms	CHEBI:18186	1436	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	A c-fms tyrosine kinase inhibitor , Ki20227 , suppresses osteoclast differentiation and osteolytic_bone_destruction in a bone metastasis model .
10910906	0	tyrosine	29,37	c-kit	14,19	tyrosine	c-kit	CHEBI:18186	3815	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|receptor receptor|amod|END_ENTITY	Inhibition of c-kit receptor tyrosine kinase activity by STI_571 , a selective tyrosine kinase inhibitor .
10910906	0	tyrosine	78,86	c-kit	14,19	tyrosine	c-kit	CHEBI:18186	3815	Chemical	Gene	inhibitor|amod|START_ENTITY STI_571|appos|inhibitor tyrosine|nmod|STI_571 tyrosine|nsubj|Inhibition Inhibition|nmod|receptor receptor|amod|END_ENTITY	Inhibition of c-kit receptor tyrosine kinase activity by STI_571 , a selective tyrosine kinase inhibitor .
10921922	1	tyrosine	190,198	c-kit	206,211	tyrosine	c-kit	CHEBI:18186	3815	Chemical	Gene	trans-activation|nmod|START_ENTITY Cross-talk|nmod|trans-activation kinase|nsubj|Cross-talk kinase|dobj|receptor receptor|amod|END_ENTITY	Cross-talk via trans-activation of the tyrosine kinase c-kit receptor .
12512837	0	tyrosine	121,129	c-kit	27,32	tyrosine	c-kit	CHEBI:18186	3815	Chemical	Gene	STI571|compound|START_ENTITY inhibited|nmod|STI571 inhibited|nsubj|activation activation|nmod|mutations mutations|amod|END_ENTITY	Constitutive activation of c-kit by the juxtamembrane but not the catalytic domain mutations is inhibited selectively by tyrosine kinase inhibitors STI571 and AG1296 .
12569358	0	tyrosine	10,18	c-kit	99,104	tyrosine	c-kit	CHEBI:18186	3815	Chemical	Gene	STI571|amod|START_ENTITY STI571|nmod|activity activity|nmod|receptors receptors|amod|END_ENTITY	Effect of tyrosine kinase inhibitor STI571 on the kinase activity of wild-type and various mutated c-kit receptors found in mast cell neoplasms .
12901973	0	tyrosine	11,19	c-kit	93,98	tyrosine	c-kit	CHEBI:18186	3815	Chemical	Gene	Effects|nmod|START_ENTITY kinase|nsubj|Effects kinase|nmod|cells cells|acl|bearing bearing|dobj|END_ENTITY	Effects of tyrosine kinase inhibitor STI571 on human mast cells bearing wild-type or mutated c-kit .
1373482	0	tyrosine	72,80	c-kit	34,39	tyrosine	c-kit	CHEBI:18186	3815	Chemical	Gene	kinase|compound|START_ENTITY evolution|nmod|kinase gene|dep|evolution gene|amod|END_ENTITY	Genomic organization of the human c-kit gene : evolution of the receptor tyrosine kinase subclass III .
15286804	0	tyrosine	30,38	c-kit	24,29	tyrosine	c-kit	CHEBI:18186	3815	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Novel mode of action of c-kit tyrosine kinase inhibitors leading to NK cell-dependent antitumor effects .
15587987	0	tyrosine	37,45	c-kit	31,36	tyrosine	c-kit	CHEBI:18186	16590(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	A functional truncated form of c-kit tyrosine kinase is produced specifically in the testis of the mouse but not the rat , pig , or human .
15791568	0	tyrosine	38,46	c-kit	64,69	tyrosine	c-kit	CHEBI:18186	3815	Chemical	Gene	kinase|amod|START_ENTITY analysis|nmod|kinase receptors|nsubj|analysis receptors|dobj|END_ENTITY	Expression and mutational analysis of tyrosine kinase receptors c-kit , PDGFRalpha , and PDGFRbeta in ovarian_cancers .
16014680	0	tyrosine	20,28	c-kit	14,19	tyrosine	c-kit	CHEBI:18186	3815	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Inhibition of c-kit tyrosine kinase by imatinib_mesylate induces apoptosis in mast cells in rheumatoid_synovia : a potential approach to the treatment of arthritis .
1698556	0	tyrosine	89,97	c-kit	83,88	tyrosine	c-kit	CHEBI:18186	16590(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Stem_cell_factor is encoded at the Sl locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor .
17256123	7	tyrosine	621,629	c-kit	745,750	tyrosine	c-kit	CHEBI:18186	3815	Chemical	Gene	inhibitors|amod|START_ENTITY role|nmod|inhibitors unclear|nsubj|role unclear|advcl|report report|nmod|over-expression over-expression|amod|END_ENTITY	The role of tyrosine kinase inhibitors on the treatment of thyroid_leiomyosarcomas is still unclear because this is the first report of c-kit over-expression in such tumors .
18622894	0	tyrosine	40,48	c-kit	56,61	tyrosine	c-kit	CHEBI:18186	3815	Chemical	Gene	analysis|nmod|START_ENTITY kinase|nsubj|analysis kinase|xcomp|END_ENTITY	Expression and mutation analysis of the tyrosine kinase c-kit in poorly differentiated and anaplastic_thyroid_carcinoma .
1912577	0	tyrosine	68,76	c-kit	94,99	tyrosine	c-kit	CHEBI:18186	16590(Tax:10090)	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|gene gene|amod|END_ENTITY	Characterization of Ws mutant allele of rats : a 12-base deletion in tyrosine kinase domain of c-kit gene .
19280218	0	tyrosine	42,50	c-kit	59,64	tyrosine	c-kit	CHEBI:18186	3815	Chemical	Gene	detection|nmod|START_ENTITY kinases|nsubj|detection kinases|dobj|END_ENTITY	Immunohistochemical detection of receptor tyrosine kinases c-kit , EGF-R , and PDGF-R in colorectal_adenocarcinomas .
21344772	0	tyrosine	50,58	c-kit	15,20	tyrosine	c-kit	CHEBI:18186	3815	Chemical	Gene	employment|amod|START_ENTITY END_ENTITY|nmod|employment	-LSB- Expression of c-kit and PDGFR and possibility of tyrosine kinase inhibitor employment in treatment of neuroblastoma in children -RSB- .
22127610	0	tyrosine	60,68	c-kit	54,59	tyrosine	c-kit	CHEBI:18186	3815	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Receptor-guided 3D-QSAR approach for the discovery of c-kit tyrosine kinase inhibitors .
7504992	0	tyrosine	115,123	c-kit	100,105	tyrosine	c-kit	CHEBI:18186	16590(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Activation of MAP kinases , pp90rsk and pp70-S6 kinases in mouse mast cells by signaling through the c-kit receptor tyrosine kinase or Fc_epsilon_RI : rapamycin inhibits activation of pp70-S6 kinase and proliferation in mouse mast cells .
7506140	6	tyrosine	968,976	c-kit	944,949	tyrosine	c-kit	CHEBI:18186	16590(Tax:10090)	Chemical	Gene	activity|amod|START_ENTITY expressed|nmod|activity expressed|dobj|receptors receptors|amod|END_ENTITY	rmSCF did not induce neurite outgrowth from DRGs of W/W embryos that did not express c-kit receptors on the cell surface and of W42/W42 mutant embryos that expressed c-kit receptors without tyrosine kinase activity .
7510297	0	tyrosine	94,102	c-kit	79,84	tyrosine	c-kit	CHEBI:18186	3815	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Epitope mapping and functional studies with three monoclonal antibodies to the c-kit receptor tyrosine kinase , YB5.B8 , 17F11 , and SR-1 .
8695840	0	tyrosine	96,104	c-kit	81,86	tyrosine	c-kit	CHEBI:18186	16590(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Involvement of transcription factor encoded by the mi locus in the expression of c-kit receptor tyrosine kinase in cultured mast cells of mice .
9092574	0	tyrosine	21,29	c-kit	98,103	tyrosine	c-kit	CHEBI:18186	3815	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nmod|complex complex|acl|containing containing|dobj|END_ENTITY	Steel_factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit , phosphatidylinositol 3-kinase , and p120 -LRB- CBL -RRB- .
9444944	0	tyrosine	148,156	c-kit	195,200	tyrosine	c-kit	CHEBI:18186	3815	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|subunit subunit|nmod|END_ENTITY	Analysis of synergism between stem_cell_factor and granulocyte-macrophage_colony-stimulating_factor on human megakaryoblastic cells : an increase in tyrosine phosphorylation of 145 kDa subunit of c-kit in two-factor combination .
9522959	3	tyrosine	471,479	c-kit	435,440	tyrosine	c-kit	CHEBI:18186	403811(Tax:9615)	Chemical	Gene	domain|compound|START_ENTITY fragment|nmod|domain fragment|amod|END_ENTITY	PROCEDURE : The nucleic acid sequence of the canine c-kit fragment of the intracellular tyrosine kinase domain was determined .
9654159	0	tyrosine	124,132	c-kit	118,123	tyrosine	c-kit	CHEBI:18186	3815	Chemical	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Haematopoietic action of flt3_ligand on cord blood-derived CD34-positive cells expressing different levels of flt3 or c-kit tyrosine kinase receptor : comparison with stem_cell_factor .
10670774	0	tyrosine	69,77	c-met	28,33	tyrosine	c-met	CHEBI:18186	24553(Tax:10116)	Chemical	Gene	kinases|compound|START_ENTITY kinase|appos|kinases kinase|compound|END_ENTITY	Rat oligodendroglia express c-met and focal adhesion kinase , protein tyrosine kinases implicated in regulating epithelial cell motility .
12837985	0	tyrosine	20,28	c-met	14,19	tyrosine	c-met	CHEBI:18186	4233	Chemical	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Expression of c-met tyrosine kinase receptor is biologically and prognostically relevant for primary cutaneous_malignant_melanomas .
1674365	0	tyrosine	72,80	c-met	0,5	tyrosine	c-met	CHEBI:18186	4233	Chemical	Gene	kinase|amod|START_ENTITY amplified|dobj|kinase amplified|nsubj|END_ENTITY	c-met is amplified but not mutated in a cell line with an activated met tyrosine kinase .
2111905	0	tyrosine	37,45	c-met	69,74	tyrosine	c-met	CHEBI:18186	4233	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|protein protein|amod|END_ENTITY	Protein kinase-c activation inhibits tyrosine phosphorylation of the c-met protein .
8408200	0	tyrosine	68,76	c-met	62,67	tyrosine	c-met	CHEBI:18186	17295(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Scatter_factor / hepatocyte_growth_factor and its receptor , the c-met tyrosine kinase , can mediate a signal exchange between mesenchyme and epithelia during mouse development .
10491645	0	tyrosine	31,39	c-ros	25,30	tyrosine	c-ros	CHEBI:18186	19886(Tax:10090)	Chemical	Gene	mice|compound|START_ENTITY mice|amod|END_ENTITY	Infertile spermatozoa of c-ros tyrosine kinase receptor knockout mice show flagellar angulation and maturational defects in cell volume regulatory mechanisms .
10645273	0	tyrosine	9,17	c-ros	25,30	tyrosine	c-ros	CHEBI:18186	19886(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|mice mice|amod|END_ENTITY	Receptor tyrosine kinase c-ros knockout mice as a model for the study of epididymal regulation of sperm function .
10906072	0	tyrosine	39,47	c-ros	33,38	tyrosine	c-ros	CHEBI:18186	19886(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|cause cause|nmod|infertility infertility|nmod|END_ENTITY	The cause of infertility of male c-ros tyrosine kinase receptor knockout mice .
1638975	0	tyrosine	47,55	c-ros	0,5	tyrosine	c-ros	CHEBI:18186	19886(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY homolog|nmod|receptor regulated|nsubj|homolog END_ENTITY|appos|regulated	c-ros : the vertebrate homolog of the sevenless tyrosine kinase receptor is tightly regulated during organogenesis in mouse embryonic development .
8675006	0	tyrosine	10,18	c-ros	4,9	tyrosine	c-ros	CHEBI:18186	19886(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	The c-ros tyrosine kinase receptor controls regionalization and differentiation of epithelial cells in the epididymis .
8660605	0	tyrosine	27,35	c-src	55,60	tyrosine	c-src	CHEBI:18186	6714	Chemical	Gene	START_ENTITY|dobj|activity activity|nmod|END_ENTITY	Measurement of the protein tyrosine kinase activity of c-src using time-resolved fluorometry of europium_chelates .
9384240	0	tyrosine	31,39	c-src	24,29	tyrosine	c-src	CHEBI:18186	6714	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|compound|END_ENTITY	Captopril inhibits pp60 -LRB- c-src -RRB- tyrosine phosphorylation in cultured human mesangial cells .
9356459	0	tyrosine	75,83	cABL	70,74	tyrosine	cABL	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	The amphiphysin-like_protein_1 -LRB- ALP1 -RRB- interacts functionally with the cABL tyrosine kinase and may play a role in cytoskeletal regulation .
10543724	0	tyrosine	26,34	cSrc	0,4	tyrosine	cSrc	CHEBI:18186	6714	Chemical	Gene	kinase|compound|START_ENTITY kinase|nsubj|END_ENTITY	cSrc is a major cytosolic tyrosine kinase in vascular tissue .
10644991	0	tyrosine	110,118	cSrc	127,131	tyrosine	cSrc	CHEBI:18186	396442(Tax:9031)	Chemical	Gene	kinases|amod|START_ENTITY kinases|amod|END_ENTITY	The SH3 and SH2 domains are capable of directing specificity in protein interactions between the non-receptor tyrosine kinases cSrc and cYes .
3415247	0	tyrosine	67,75	calmodulin	32,42	tyrosine	calmodulin	CHEBI:18186	100682497	Chemical	Gene	START_ENTITY|nsubj|phosphorylation phosphorylation|nmod|END_ENTITY	The in vitro phosphorylation of calmodulin by the insulin receptor tyrosine kinase .
21930781	0	tyrosine	43,51	casein_kinase_2	16,31	tyrosine	casein kinase 2	CHEBI:18186	399320(Tax:8355)	Chemical	Gene	START_ENTITY|nsubj|Contribution Contribution|nmod|END_ENTITY	Contribution of casein_kinase_2 and spleen tyrosine kinase to CFTR trafficking and protein kinase A-induced activity .
18086677	0	tyrosine	50,58	caspase-8	99,108	tyrosine	caspase-8	CHEBI:18186	841	Chemical	Gene	phosphorylation|amod|START_ENTITY regulation|nmod|phosphorylation regulation|nmod|END_ENTITY	Dynamic regulation of neutrophil survival through tyrosine phosphorylation or dephosphorylation of caspase-8 .
18216014	0	tyrosine	29,37	caspase_8	49,58	tyrosine	caspase 8	CHEBI:18186	841	Chemical	Gene	residue|compound|START_ENTITY residue|nmod|END_ENTITY	Identification of a critical tyrosine residue in caspase_8 that promotes cell migration .
12036959	0	tyrosine	35,43	caveolin-1	63,73	tyrosine	caveolin-1	CHEBI:18186	857	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	The insulin_receptor catalyzes the tyrosine phosphorylation of caveolin-1 .
15466865	0	tyrosine	13,21	caveolin-1	41,51	tyrosine	caveolin-1	CHEBI:18186	857	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Src-mediated tyrosine phosphorylation of caveolin-1 induces its association with membrane_type_1_matrix_metalloproteinase .
15748889	0	tyrosine	24,32	caveolin-1	13,23	tyrosine	caveolin-1	CHEBI:18186	857	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	ACTH-induced caveolin-1 tyrosine phosphorylation is related to podosome assembly in Y1 adrenal cells .
16368181	0	tyrosine	19,27	caveolin-1	47,57	tyrosine	caveolin-1	CHEBI:18186	857	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Oestrogen-mediated tyrosine phosphorylation of caveolin-1 and its effect on the oestrogen receptor localisation : an in vivo study .
15288650	0	tyrosine	30,38	caveolin-2	58,68	tyrosine	caveolin-2	CHEBI:18186	363425(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Ocadaic_acid treatment causes tyrosine phosphorylation of caveolin-2 and induces internalization of caveolae in rat peritoneal macrophages .
7925293	0	tyrosine	43,51	cbl	90,93	tyrosine	cbl	CHEBI:18186	12402(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|product product|nmod|oncogene oncogene|compound|END_ENTITY	Tumour induction by activated abl involves tyrosine phosphorylation of the product of the cbl oncogene .
8524328	0	tyrosine	88,96	cbl	19,22	tyrosine	cbl	CHEBI:18186	867	Chemical	Gene	manner|amod|START_ENTITY Crk|nmod|manner forms|nmod|Crk forms|nsubj|product product|nmod|oncogene oncogene|compound|END_ENTITY	The product of the cbl oncogene forms stable complexes in vivo with endogenous Crk in a tyrosine phosphorylation-dependent manner .
8649859	0	tyrosine	27,35	cbl	23,26	tyrosine	cbl	CHEBI:18186	12402(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	The two major sites of cbl tyrosine phosphorylation in abl-transformed cells select the crkL SH2 domain .
8770364	0	tyrosine	47,55	cbl	4,7	tyrosine	cbl	CHEBI:18186	12402(Tax:10090)	Chemical	Gene	kinases|compound|START_ENTITY substrate|nmod|kinases oncogene|dep|substrate oncogene|compound|END_ENTITY	The cbl oncogene : a novel substrate of protein tyrosine kinases .
2473839	0	tyrosine	11,19	cdc2	39,43	tyrosine	cdc2	CHEBI:18186	12534(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Reversible tyrosine phosphorylation of cdc2 : dephosphorylation accompanies activation during entry into mitosis .
1836978	0	tyrosine	29,37	cdc25	23,28	tyrosine	cdc25	CHEBI:18186	995	Chemical	Gene	phosphatases|compound|START_ENTITY phosphatases|amod|END_ENTITY	Specific activation of cdc25 tyrosine phosphatases by B-type cyclins : evidence for multiple roles of mitotic cyclins .
1913817	0	tyrosine	20,28	cdc25	0,5	tyrosine	cdc25	CHEBI:18186	43466(Tax:7227)	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|nsubj|END_ENTITY	cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2 .
11752153	0	tyrosine	72,80	cdc25A	65,71	tyrosine	cdc25A	CHEBI:18186	993	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|amod|END_ENTITY	Human_papillomavirus_type_16 E7 maintains elevated levels of the cdc25A tyrosine phosphatase during deregulation of cell cycle arrest .
8700513	0	tyrosine	66,74	cdc25a	59,65	tyrosine	cdc25a	CHEBI:18186	993	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|amod|END_ENTITY	S-phase induction by adenovirus E1A requires activation of cdc25a tyrosine phosphatase .
8095711	0	tyrosine	69,77	ciliary_neurotrophic_factor	25,52	tyrosine	ciliary neurotrophic factor	CHEBI:18186	25707(Tax:10116)	Chemical	Gene	expression|amod|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	Convergent regulation by ciliary_neurotrophic_factor and dopamine of tyrosine hydroxylase expression in cultures of rat substantia nigra .
9285712	0	tyrosine	12,20	ciliary_neurotrophic_factor	60,87	tyrosine	ciliary neurotrophic factor	CHEBI:18186	1270	Chemical	Gene	SHP-2|compound|START_ENTITY regulates|nsubj|SHP-2 regulates|dobj|induction induction|compound|END_ENTITY	The protein tyrosine phosphatase SHP-2 negatively regulates ciliary_neurotrophic_factor induction of gene expression .
19652227	0	tyrosine	49,57	collapsin_response_mediator_protein_2	77,114	tyrosine	collapsin response mediator protein 2	CHEBI:18186	1808	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Semaphorin3A signaling mediated by Fyn-dependent tyrosine phosphorylation of collapsin_response_mediator_protein_2 at tyrosine 32 .
19887542	0	tyrosine	121,129	colony-stimulating_factor-1	36,63	tyrosine	colony-stimulating factor-1	CHEBI:18186	12977(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|receptor receptor|amod|END_ENTITY	JNJ-28312141 , a novel orally active colony-stimulating_factor-1 receptor/FMS-related _ receptor_tyrosine_kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors , bone metastases , and acute_myeloid_leukemia .
15236912	0	tyrosine	146,154	colony-stimulating_factor-1_receptor	109,145	tyrosine	colony-stimulating factor-1 receptor	CHEBI:18186	1436	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Development of a quantitative , high-throughput cell-based enzyme-linked immunosorbent assay for detection of colony-stimulating_factor-1_receptor tyrosine kinase inhibitors .
21880693	0	tyrosine	117,125	colony_stimulating_factor-1_receptor	80,116	tyrosine	colony stimulating factor-1 receptor	CHEBI:18186	1436	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Characterization of kinase inhibitors using different phosphorylation states of colony_stimulating_factor-1_receptor tyrosine kinase .
17149706	0	tyrosine	111,119	connexin40	95,105	tyrosine	connexin40	CHEBI:18186	14613(Tax:10090)	Chemical	Gene	targeting|nmod|START_ENTITY targeting|dobj|END_ENTITY	Lipopolysaccharide reduces electrical coupling in microvascular endothelial cells by targeting connexin40 in a tyrosine - , ERK1/2 - , PKA - , and PKC-dependent manner .
14681016	0	tyrosine	50,58	connexin43	15,25	tyrosine	connexin43	CHEBI:18186	2697	Chemical	Gene	START_ENTITY|nsubj|Association Association|nmod|END_ENTITY	Association of connexin43 with a receptor protein tyrosine phosphatase .
12384989	0	tyrosine	74,82	connexin_43	102,113	tyrosine	connexin 43	CHEBI:18186	2697	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Lipopolysaccharide-induced reductions in cellular coupling correlate with tyrosine phosphorylation of connexin_43 .
9852230	0	tyrosine	37,45	connexin_43	65,76	tyrosine	connexin 43	CHEBI:18186	2697	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Gap junctional communication and the tyrosine phosphorylation of connexin_43 in interaction between breast_cancer and endothelial cells .
24239742	0	tyrosine	114,122	coronin-1C	142,152	tyrosine	coronin-1C	CHEBI:18186	23603	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Nox4 redox regulation of PTP1B contributes to the proliferation and migration_of_glioblastoma cells by modulating tyrosine phosphorylation of coronin-1C .
10865942	0	tyrosine	75,83	cortactin	103,112	tyrosine	cortactin	CHEBI:18186	2017	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Interaction of fibrinogen with saphenous vein endothelial cells stimulates tyrosine phosphorylation of cortactin .
15030313	0	tyrosine	31,39	cortactin	59,68	tyrosine	cortactin	CHEBI:18186	2017	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Actin depolymerization-induced tyrosine phosphorylation of cortactin : the role of Fer kinase .
16162656	0	tyrosine	11,19	cortactin	39,48	tyrosine	cortactin	CHEBI:18186	60465(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Effects of tyrosine phosphorylation of cortactin on podosome formation in A7r5 vascular smooth muscle cells .
16756952	0	tyrosine	61,69	cortactin	89,98	tyrosine	cortactin	CHEBI:18186	13043(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Anti-estrogen ICI_182 .780 and anti-androgen flutamide induce tyrosine phosphorylation of cortactin in the ectoplasmic specialization between the Sertoli cell and spermatids in the mouse testis .
16905744	0	tyrosine	15,23	cortactin	43,52	tyrosine	cortactin	CHEBI:18186	2017	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	CXCL12 induces tyrosine phosphorylation of cortactin , which plays a role in CXC_chemokine_receptor_4-mediated extracellular signal-regulated kinase activation and chemotaxis .
17420251	0	tyrosine	39,47	cortactin	67,76	tyrosine	cortactin	CHEBI:18186	2017	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Receptor-mediated endocytosis involves tyrosine phosphorylation of cortactin .
18387954	0	tyrosine	26,34	cortactin	16,25	tyrosine	cortactin	CHEBI:18186	2017	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	PTP1B regulates cortactin tyrosine phosphorylation by targeting Tyr446 .
20971703	0	tyrosine	9,17	cortactin	43,52	tyrosine	cortactin	D014443	2017	Chemical	Gene	sites|amod|START_ENTITY sites|nmod|END_ENTITY	Specific tyrosine phosphorylation sites on cortactin regulate Nck1-dependent actin polymerization in invadopodia .
7540134	0	tyrosine	58,66	cortactin	86,95	tyrosine	cortactin	CHEBI:18186	2017	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Invasion of epithelial cells by Shigella_flexneri induces tyrosine phosphorylation of cortactin by a pp60c-src-mediated signalling pathway .
7909803	0	tyrosine	53,61	cortactin	117,126	tyrosine	cortactin	CHEBI:18186	60465(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Intercellular_adhesion_molecule_1 activation induces tyrosine phosphorylation of the cytoskeleton-associated protein cortactin in brain microvessel endothelial cells .
9459347	0	tyrosine	53,61	cortactin	88,97	tyrosine	cortactin	CHEBI:18186	2017	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Thrombopoietin activates human platelets and induces tyrosine phosphorylation of p80/85 cortactin .
9148770	0	tyrosine	22,30	csk	18,21	tyrosine	csk	CHEBI:18186	1445	Chemical	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification of csk tyrosine phosphorylation sites and a tyrosine residue important for kinase domain structure .
20974127	0	tyrosine	91,99	ctn	86,89	tyrosine	ctn	CHEBI:18186	1500	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|compound|END_ENTITY	Ga -LRB- 12 -RRB- binds to the N-terminal regulatory domain of p120 -LRB- ctn -RRB- , and downregulates p120 -LRB- ctn -RRB- tyrosine phosphorylation induced by Src family kinases via a RhoA independent mechanism .
10930570	0	tyrosine	76,84	cyclin_D2	104,113	tyrosine	cyclin D2	CHEBI:18186	894	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	The mitogenic signaling pathway for fibroblast_growth_factor-2 involves the tyrosine phosphorylation of cyclin_D2 in MCF-7 human breast_cancer cells .
21203429	0	tyrosine	15,23	cysteinyl_leukotriene_receptor_1	43,75	tyrosine	cysteinyl leukotriene receptor 1	CHEBI:18186	10800	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Ligand-induced tyrosine phosphorylation of cysteinyl_leukotriene_receptor_1 triggers internalization and signaling in intestinal epithelial cells .
17202652	0	tyrosine	22,30	cytochrome_C	43,55	tyrosine	cytochrome C	CHEBI:18186	54205	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	Nitration of specific tyrosine residues of cytochrome_C is associated with caspase-cascade inactivation .
21454570	0	tyrosine	20,28	cytochrome_b	40,52	tyrosine	cytochrome b	CHEBI:18186	4519	Chemical	Gene	residue|compound|START_ENTITY residue|nmod|END_ENTITY	Loss of a conserved tyrosine residue of cytochrome_b induces reactive_oxygen_species production by cytochrome_bc1 .
19249841	0	tyrosine	26,34	cytochrome_c	47,59	tyrosine	cytochrome c	CHEBI:18186	54205	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Fluorescence lifetimes of tyrosine residues in cytochrome_c '' as local probes to study protein unfolding .
9715262	0	tyrosine	87,95	cytosolic_phospholipase_A2	115,141	tyrosine	cytosolic phospholipase A2	CHEBI:18186	5321	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Lipopolysaccharide induction of monocyte matrix metalloproteinases is regulated by the tyrosine phosphorylation of cytosolic_phospholipase_A2 .
8142479	0	tyrosine	18,26	dUTPase	90,97	tyrosine	dUTPase	CHEBI:18186	34529(Tax:7227)	Chemical	Gene	Identification|nmod|START_ENTITY END_ENTITY|nsubj|Identification	Identification of tyrosine as a functional residue in the active site of Escherichia_coli dUTPase .
8781490	0	tyrosine	78,86	density-enhanced_phosphatase-1	36,66	tyrosine	density-enhanced phosphatase-1	CHEBI:18186	29645(Tax:10116)	Chemical	Gene	phosphatase|compound|START_ENTITY END_ENTITY|appos|phosphatase	Cloning and characterization of rat density-enhanced_phosphatase-1 , a protein tyrosine phosphatase expressed by vascular cells .
18424699	0	tyrosine	14,22	diacylglycerol_kinase_alpha	42,69	tyrosine	diacylglycerol kinase alpha	CHEBI:18186	1606	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Lck-dependent tyrosine phosphorylation of diacylglycerol_kinase_alpha regulates its membrane association in T cells .
17350651	0	tyrosine	24,32	disabled-1	13,23	tyrosine	disabled-1	CHEBI:18186	374083(Tax:9031)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Hierarchical disabled-1 tyrosine phosphorylation in Src family kinase activation and neurite formation .
12223548	0	tyrosine	67,75	doublecortin	18,30	tyrosine	doublecortin	CHEBI:18186	1641	Chemical	Gene	activity|nmod|START_ENTITY activity|nmod|END_ENTITY	A new activity of doublecortin in recognition of the phospho-FIGQY tyrosine in the cytoplasmic domain of neurofascin .
21655159	0	tyrosine	63,71	egfr	58,62	tyrosine	egfr	CHEBI:18186	1956	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Managing treatment-related adverse events associated with egfr tyrosine kinase inhibitors in advanced non-small-cell lung_cancer .
24825983	0	tyrosine	59,67	egfr	76,80	tyrosine	egfr	CHEBI:18186	1956	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	3d QSAR studies on a series of quinazoline derrivatives as tyrosine kinase -LRB- egfr -RRB- inhibitor : the k-nearest neighbor molecular field analysis approach .
22266903	0	tyrosine	101,109	emerin	129,135	tyrosine	emerin	CHEBI:18186	2010	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Sumoylated protein tyrosine phosphatase 1B localizes to the inner nuclear membrane and regulates the tyrosine phosphorylation of emerin .
21792912	0	tyrosine	41,49	endothelin-1	14,26	tyrosine	endothelin-1	CHEBI:18186	1906	Chemical	Gene	kinases|compound|START_ENTITY kinases|amod|END_ENTITY	The effect of endothelin-1 on Src-family tyrosine kinases and Na,K-ATPase activity in porcine lens epithelium .
16023617	0	tyrosine	65,73	endothelins_1_and_3	98,117	tyrosine	endothelins 1 and 3	CHEBI:18186	24323(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Involvement of nitric_oxide pathways in short term modulation of tyrosine hydroxylase activity by endothelins_1_and_3 in the rat anterior hypothalamus .
15848799	0	tyrosine	14,22	ephexin1	42,50	tyrosine	ephexin1	CHEBI:18186	424744(Tax:9031)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Eph-dependent tyrosine phosphorylation of ephexin1 modulates growth cone collapse .
15367698	0	tyrosine	146,154	epidermal_growth_factor	113,136	tyrosine	epidermal growth factor	CHEBI:18186	1950	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	ZD6474 , a vascular_endothelial_growth_factor receptor tyrosine kinase inhibitor with additional activity against epidermal_growth_factor receptor tyrosine kinase , inhibits orthotopic growth and angiogenesis of gastric_cancer .
6193426	0	tyrosine	46,54	epidermal_growth_factor	74,97	tyrosine	epidermal growth factor	CHEBI:18186	1950	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Enhancement of polyoma virus middle T antigen tyrosine phosphorylation by epidermal_growth_factor .
7867573	0	tyrosine	42,50	epidermal_growth_factor	11,34	tyrosine	epidermal growth factor	CHEBI:18186	1950	Chemical	Gene	phosphorylation|amod|START_ENTITY END_ENTITY|nmod|phosphorylation	Effects of epidermal_growth_factor on the tyrosine phosphorylation of mitogen-activated protein kinases in monolayer cultures of porcine granulosa cells .
8486681	0	tyrosine	51,59	epidermal_growth_factor	84,107	tyrosine	epidermal growth factor	CHEBI:18186	1950	Chemical	Gene	importance|nmod|START_ENTITY importance|nmod|END_ENTITY	The functional importance of hydrophobicity of the tyrosine at position 13 of human epidermal_growth_factor in receptor binding .
8078931	0	tyrosine	58,66	epidermal_growth_factor-receptor	25,57	tyrosine	epidermal growth factor-receptor	CHEBI:18186	24329(Tax:10116)	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Ras mediates Src but not epidermal_growth_factor-receptor tyrosine kinase signaling pathways in GH4 neuroendocrine cells .
10023672	0	tyrosine	53,61	epidermal_growth_factor_receptor	217,249	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	expression|nmod|START_ENTITY phosphatase|nsubj|expression phosphatase|nmod|cells cells|dep|interaction interaction|nmod|END_ENTITY	Differential expression and translocation of protein tyrosine phosphatase 1B-related proteins in ME-180 tumor cells expressing apoptotic sensitivity and resistance to tumor_necrosis_factor : potential interaction with epidermal_growth_factor_receptor .
10049496	0	tyrosine	104,112	epidermal_growth_factor_receptor	71,103	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	A basic residue , Lys 782 , composes part of the ATP-binding site on the epidermal_growth_factor_receptor tyrosine kinase .
10068444	0	tyrosine	26,34	epidermal_growth_factor_receptor	82,114	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	Modulation|nmod|START_ENTITY kinase|nsubj|Modulation kinase|dobj|activity activity|nmod|END_ENTITY	Modulation of the protein tyrosine kinase activity and autophosphorylation of the epidermal_growth_factor_receptor by its juxtamembrane region .
10069801	0	tyrosine	19,27	epidermal_growth_factor_receptor	99,131	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	Phosphorylation|nmod|START_ENTITY required|nsubjpass|Phosphorylation required|nmod|change change|nmod|tail tail|compound|END_ENTITY	Phosphorylation of tyrosine 992 , 1068 , and 1086 is required for conformational change of the human epidermal_growth_factor_receptor c-terminal tail .
10074364	0	tyrosine	30,38	epidermal_growth_factor_receptor	70,102	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinase|amod|START_ENTITY kinase|nmod|mutant mutant|nmod|END_ENTITY	Kinetics of activation of the tyrosine kinase of a deletion mutant of epidermal_growth_factor_receptor missing the sites of self-phosphorylation .
10086326	0	tyrosine	60,68	epidermal_growth_factor_receptor	27,59	tyrosine	epidermal growth factor receptor	CHEBI:18186	13649(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Irreversible inhibition of epidermal_growth_factor_receptor tyrosine kinase with in vivo activity by N - -LSB- 4 - -LSB- -LRB- 3-bromophenyl -RRB- amino -RSB- -6 - quinazolinyl -RSB- -2 - butynamide -LRB- CL-387 ,785 -RRB- .
10409647	0	tyrosine	97,105	epidermal_growth_factor_receptor	39,71	tyrosine	epidermal growth factor receptor	CHEBI:18186	24329(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|pathways pathways|nmod|transactivation transactivation|compound|END_ENTITY	Distinct calcium-dependent pathways of epidermal_growth_factor_receptor transactivation and PYK2 tyrosine phosphorylation in PC12 cells .
10411909	0	tyrosine	28,36	epidermal_growth_factor_receptor	77,109	tyrosine	epidermal growth factor receptor	CHEBI:18186	13649(Tax:10090)	Chemical	Gene	evidence|dep|START_ENTITY enhancer|nsubj|evidence enhancer|nmod|END_ENTITY	Genetic evidence that Shp-2 tyrosine phosphatase is a signal enhancer of the epidermal_growth_factor_receptor in mammals .
10435588	0	tyrosine	26,34	epidermal_growth_factor_receptor	84,116	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	phosphatase|nsubj|START_ENTITY phosphatase|ccomp|modulates modulates|xcomp|signaling signaling|nmod|END_ENTITY	The transmembrane protein tyrosine phosphatase RPTPsigma modulates signaling of the epidermal_growth_factor_receptor in A431 cells .
10446212	0	tyrosine	81,89	epidermal_growth_factor_receptor	146,178	tyrosine	epidermal growth factor receptor	CHEBI:18186	24329(Tax:10116)	Chemical	Gene	kinase|compound|START_ENTITY activation|nmod|kinase proline-rich_tyrosine_kinase_2|nsubj|activation proline-rich_tyrosine_kinase_2|advcl|affecting affecting|dobj|transactivation transactivation|compound|END_ENTITY	Nitric_oxide inhibits angiotensin_II-induced activation of the calcium-sensitive tyrosine kinase proline-rich_tyrosine_kinase_2 without affecting epidermal_growth_factor_receptor transactivation .
10454198	0	tyrosine	61,69	epidermal_growth_factor_receptor	18,50	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinases|amod|START_ENTITY family|nmod|kinases family|compound|END_ENTITY	Inhibition of the epidermal_growth_factor_receptor family of tyrosine kinases as an approach to cancer chemotherapy : progression from reversible to irreversible inhibitors .
10495354	0	tyrosine	145,153	epidermal_growth_factor_receptor	102,134	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinases|amod|START_ENTITY family|nmod|kinases family|compound|END_ENTITY	The rationale and strategy used to develop a series of highly potent , irreversible , inhibitors of the epidermal_growth_factor_receptor family of tyrosine kinases .
10600488	0	tyrosine	120,128	epidermal_growth_factor_receptor	41,73	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	phosphatase|amod|START_ENTITY activation|nmod|phosphatase reduces|nmod|activation reduces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Phorbol_ester reduces phosphorylation of epidermal_growth_factor_receptor in pancreatic_cancer cells by activation of a tyrosine phosphatase .
10610698	0	tyrosine	54,62	epidermal_growth_factor_receptor	21,53	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|assay assay|nmod|END_ENTITY	Ratiometric assay of epidermal_growth_factor_receptor tyrosine kinase activation .
10621850	0	tyrosine	109,117	epidermal_growth_factor_receptor	76,108	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|Apoptosis Apoptosis|nmod|line line|acl|induced induced|nmod|END_ENTITY	Apoptosis and growth inhibition of head_and_neck_tumor cell line induced by epidermal_growth_factor_receptor tyrosine kinase inhibitor .
10632369	0	tyrosine	152,160	epidermal_growth_factor_receptor	119,151	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Specificity of alpha-cyano-beta-hydroxy-beta-methyl-n - -LSB- 4 - -LRB- trifluoromethoxy -RRB- phe_nyl -RSB- - propenamide as an inhibitor of the epidermal_growth_factor_receptor tyrosine kinase .
10639288	2	tyrosine	182,190	epidermal_growth_factor_receptor	149,181	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	6,5,6-tricyclic _ benzothieno -LSB- 3 , _ 2-d -RSB- pyrimidines and pyrimido -LSB- 5,4-b - -RSB- _ and _ - -LSB- 4,5-b -RSB- __ ndoles as potent inhibitors of the epidermal_growth_factor_receptor tyrosine kinase .
10702262	0	tyrosine	85,93	epidermal_growth_factor_receptor	52,84	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Reversible G -LRB- 1 -RRB- arrest induced by inhibition of the epidermal_growth_factor_receptor tyrosine kinase requires up-regulation of p27 -LRB- KIP1 -RRB- independent of MAPK activity .
10713051	1	tyrosine	95,103	epidermal_growth_factor_receptor	139,171	tyrosine	epidermal growth factor receptor	CHEBI:18186	13649(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|status status|compound|END_ENTITY	Enhanced caveolin-1 tyrosine phosphorylation following aberrant epidermal_growth_factor_receptor status .
10850439	0	tyrosine	70,78	epidermal_growth_factor_receptor	16,48	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitor|amod|START_ENTITY signaling|nmod|inhibitor END_ENTITY|acl|signaling	Blockade of the epidermal_growth_factor_receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic_carcinoma .
10851300	2	tyrosine	82,90	epidermal_growth_factor_receptor	110,142	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Curcumin inhibits tyrosine kinase activity of epidermal_growth_factor_receptor and depletes the protein .
10987266	0	tyrosine	47,55	epidermal_growth_factor_receptor	14,46	tyrosine	epidermal growth factor receptor	CHEBI:18186	13649(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Inhibition of epidermal_growth_factor_receptor tyrosine kinase fails to suppress adenoma formation in ApcMin mice but induces duodenal_injury .
11189010	0	tyrosine	27,35	epidermal_growth_factor_receptor	45,77	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|dobj|ErbB2 ErbB2|dep|END_ENTITY	Expression of the receptor tyrosine kinases , epidermal_growth_factor_receptor , ErbB2 , and ErbB3 , in human ocular surface epithelia .
11401489	0	tyrosine	31,39	epidermal_growth_factor_receptor	73,105	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	fluidity|nmod|START_ENTITY Effect|nmod|fluidity kinase|nsubj|Effect kinase|dobj|activity activity|nmod|END_ENTITY	Effect of membrane fluidity on tyrosine kinase activity of reconstituted epidermal_growth_factor_receptor .
11459659	0	tyrosine	119,127	epidermal_growth_factor_receptor	86,118	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Studies leading to the identification of ZD1839 -LRB- IRESSA -RRB- : an orally active , selective epidermal_growth_factor_receptor tyrosine kinase inhibitor targeted to the treatment of cancer .
11495584	0	tyrosine	183,191	epidermal_growth_factor_receptor	92,124	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|inhibitors inhibitors|nmod|END_ENTITY	6-Substituted-4 - -LRB- 3-bromophenylamino -RRB- quinazolines as putative irreversible inhibitors of the epidermal_growth_factor_receptor -LRB- EGFR -RRB- and human epidermal_growth_factor_receptor -LRB- HER-2 -RRB- tyrosine kinases with enhanced antitumor activity .
11514572	0	tyrosine	12,20	epidermal_growth_factor_receptor	111,143	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	phosphatase|nsubj|START_ENTITY phosphatase|ccomp|suppresses suppresses|dobj|tumorigenicity tumorigenicity|nmod|cells cells|acl|expressing expressing|dobj|END_ENTITY	The protein tyrosine phosphatase TCPTP suppresses the tumorigenicity of glioblastoma cells expressing a mutant epidermal_growth_factor_receptor .
11565870	0	tyrosine	140,148	epidermal_growth_factor_receptor	69,101	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitor|compound|START_ENTITY cisplatin|nmod|inhibitor sensitized|xcomp|cisplatin END_ENTITY|acl|sensitized	Human glioblastoma xenografts overexpressing a tumor-specific mutant epidermal_growth_factor_receptor sensitized to cisplatin by the AG1478 tyrosine kinase inhibitor .
11566906	0	tyrosine	124,132	epidermal_growth_factor_receptor	40,72	tyrosine	epidermal growth factor receptor	CHEBI:18186	13649(Tax:10090)	Chemical	Gene	phosphatase|compound|START_ENTITY association|nmod|phosphatase inhibits|nmod|association inhibits|dobj|transactivation transactivation|compound|END_ENTITY	Angiotensin_II_type_2_receptor inhibits epidermal_growth_factor_receptor transactivation by increasing association of SHP-1 tyrosine phosphatase .
11706397	0	tyrosine	66,74	epidermal_growth_factor_receptor	33,65	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|studies studies|nmod|END_ENTITY	Pharmacodynamic studies with the epidermal_growth_factor_receptor tyrosine kinase inhibitor ZD1839 .
11751524	0	tyrosine	100,108	epidermal_growth_factor_receptor	53,85	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinase|amod|START_ENTITY family|amod|kinase family|amod|END_ENTITY	High levels of HER-2 expression alter the ability of epidermal_growth_factor_receptor -LRB- EGFR -RRB- family tyrosine kinase inhibitors to inhibit EGFR phosphorylation in vivo .
11782368	0	tyrosine	43,51	epidermal_growth_factor_receptor	10,42	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of epidermal_growth_factor_receptor tyrosine kinase inhibition on epithelial proliferation in normal and premalignant breast .
11956154	0	tyrosine	73,81	epidermal_growth_factor_receptor	149,181	tyrosine	epidermal growth factor receptor	CHEBI:18186	13649(Tax:10090)	Chemical	Gene	phosphorylated|advmod|START_ENTITY phosphorylated|nmod|activation activation|nmod|mutant mutant|compound|END_ENTITY	The endocytosis-linked protein dynamin associates with caveolin-1 and is tyrosine phosphorylated in response to the activation of a noninternalizing epidermal_growth_factor_receptor mutant .
11980649	0	tyrosine	102,110	epidermal_growth_factor_receptor	69,101	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	ZD1839 -LRB- Iressa -RRB- induces antiangiogenic effects through inhibition of epidermal_growth_factor_receptor tyrosine kinase .
11983694	0	tyrosine	73,81	epidermal_growth_factor_receptor	37,69	tyrosine	epidermal growth factor receptor	CHEBI:18186	13649(Tax:10090)	Chemical	Gene	845|amod|START_ENTITY END_ENTITY|nmod|845	Src-dependent phosphorylation of the epidermal_growth_factor_receptor on tyrosine 845 is required for zinc-induced Ras activation .
12011079	0	tyrosine	14,22	epidermal_growth_factor_receptor	109,141	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	phosphorylation|compound|START_ENTITY regulates|nsubj|phosphorylation regulates|dobj|self-assembly self-assembly|nmod|END_ENTITY	Src-dependent tyrosine phosphorylation regulates dynamin self-assembly and ligand-induced endocytosis of the epidermal_growth_factor_receptor .
12018405	0	tyrosine	8,16	epidermal_growth_factor_receptor	53,85	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	phosphatases|compound|START_ENTITY phosphatases|dep|dephosphorylating dephosphorylating|dobj|END_ENTITY	Protein tyrosine phosphatases : dephosphorylating the epidermal_growth_factor_receptor .
12021271	0	tyrosine	10,18	epidermal_growth_factor_receptor	95,127	tyrosine	epidermal growth factor receptor	CHEBI:18186	24329(Tax:10116)	Chemical	Gene	kinase|amod|START_ENTITY Effect|nmod|kinase inhibitors|nsubj|Effect inhibitors|nmod|recruitment recruitment|nmod|END_ENTITY	Effect of tyrosine kinase inhibitors on clathrin-coated pit recruitment and internalization of epidermal_growth_factor_receptor .
12127526	0	tyrosine	176,184	epidermal_growth_factor_receptor	114,146	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinases|compound|START_ENTITY kinases|amod|pyrimidin-6-ones pyrimidin-6-ones|nmod|class class|nmod|inhibitors inhibitors|nmod|END_ENTITY	Rational design of 4,5-disubstituted-5 ,7 - dihydro-pyrrolo -LSB- 2,3-d -RSB- pyrimidin-6-ones as a novel class of inhibitors of epidermal_growth_factor_receptor -LRB- EGF-R -RRB- and Her2 -LRB- p185 -LRB- erbB -RRB- -RRB- tyrosine kinases .
12168845	0	tyrosine	49,57	epidermal_growth_factor_receptor	16,48	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Blockade of the epidermal_growth_factor_receptor tyrosine kinase activity by quercetin and luteolin leads to growth inhibition and apoptosis of pancreatic_tumor cells .
12409327	0	tyrosine	120,128	epidermal_growth_factor_receptor	87,119	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitor|compound|START_ENTITY inhibitor|compound|END_ENTITY	Phase I safety , pharmacokinetic , and pharmacodynamic trial of ZD1839 , a selective oral epidermal_growth_factor_receptor tyrosine kinase inhibitor , in patients with five selected solid tumor types .
12467226	0	tyrosine	77,85	epidermal_growth_factor_receptor	37,69	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	effects|parataxis|START_ENTITY effects|nmod|END_ENTITY	The effects of the novel , reversible epidermal_growth_factor_receptor / ErbB-2 tyrosine kinase inhibitor , GW2016 , on the growth of human normal and tumor-derived cell lines in vitro and in vivo .
12502359	1	tyrosine	166,174	epidermal_growth_factor_receptor	198,230	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	The design of an orally active , irreversible inhibitor of the tyrosine kinase activity of the epidermal_growth_factor_receptor -LRB- EGFR -RRB- and the human epidermal_growth_factor_receptor-2 -LRB- HER-2 -RRB- .
12522132	0	tyrosine	19,27	epidermal_growth_factor_receptor	126,158	tyrosine	epidermal growth factor receptor	CHEBI:18186	24329(Tax:10116)	Chemical	Gene	319|amod|START_ENTITY Phosphorylation|nmod|319 mediates|nsubj|Phosphorylation mediates|dobj|trans-activation trans-activation|nmod|END_ENTITY	Phosphorylation of tyrosine 319 of the angiotensin_II_type_1_receptor mediates angiotensin_II-induced trans-activation of the epidermal_growth_factor_receptor .
12589790	0	tyrosine	39,47	epidermal_growth_factor_receptor	71,103	tyrosine	epidermal growth factor receptor	CHEBI:18186	24329(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Protein_kinase_A mediates cAMP-induced tyrosine phosphorylation of the epidermal_growth_factor_receptor .
12594213	0	tyrosine	127,135	epidermal_growth_factor_receptor	33,65	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitors|compound|START_ENTITY formation|nmod|inhibitors hotspot|nmod|formation reveals|dobj|hotspot reveals|nsubj|Mutation Mutation|nmod|threonine threonine|nmod|END_ENTITY	Mutation of threonine 766 in the epidermal_growth_factor_receptor reveals a hotspot for resistance formation against selective tyrosine kinase inhibitors .
12684395	0	tyrosine	59,67	epidermal_growth_factor_receptor	19,51	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitor|amod|START_ENTITY END_ENTITY|dep|inhibitor	ZD1839 , a specific epidermal_growth_factor_receptor -LRB- EGFR -RRB- tyrosine kinase inhibitor , induces the formation of inactive EGFR/HER2 and EGFR/HER3 heterodimers and prevents heregulin signaling in HER2-overexpressing breast_cancer cells .
12684431	0	tyrosine	183,191	epidermal_growth_factor_receptor	150,182	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Antitumor effects of ZD6474 , a small molecule vascular_endothelial_growth_factor receptor tyrosine kinase inhibitor , with additional activity against epidermal_growth_factor_receptor tyrosine kinase .
12684431	0	tyrosine	90,98	epidermal_growth_factor_receptor	150,182	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nmod|kinase kinase|compound|END_ENTITY	Antitumor effects of ZD6474 , a small molecule vascular_endothelial_growth_factor receptor tyrosine kinase inhibitor , with additional activity against epidermal_growth_factor_receptor tyrosine kinase .
12684433	0	tyrosine	92,100	epidermal_growth_factor_receptor	59,91	tyrosine	epidermal growth factor receptor	CHEBI:18186	13649(Tax:10090)	Chemical	Gene	ZD1839|amod|START_ENTITY ZD1839|compound|END_ENTITY	Combination of a selective cyclooxygenase-2 inhibitor with epidermal_growth_factor_receptor tyrosine kinase inhibitor ZD1839 and protein kinase A antisense causes cooperative antitumor and antiangiogenic effect .
12700278	0	tyrosine	166,174	epidermal_growth_factor_receptor	15,47	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinase|amod|START_ENTITY ZD1839|amod|kinase Suppression|nmod|ZD1839 Suppression|nmod|END_ENTITY	Suppression of epidermal_growth_factor_receptor , mitogen-activated protein kinase , and Pak1 pathways and invasiveness of human cutaneous_squamous_cancer cells by the tyrosine kinase inhibitor ZD1839 -LRB- Iressa -RRB- .
12746449	0	tyrosine	76,84	epidermal_growth_factor_receptor	36,68	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	activity|amod|START_ENTITY alters|dobj|activity alters|nsubj|mutation mutation|nmod|END_ENTITY	A carboxyl-terminal mutation of the epidermal_growth_factor_receptor alters tyrosine kinase activity and substrate specificity as measured by a fluorescence polarization assay .
12775734	0	tyrosine	52,60	epidermal_growth_factor_receptor	19,51	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|trial trial|nmod|END_ENTITY	Pilot trial of the epidermal_growth_factor_receptor tyrosine kinase inhibitor gefitinib plus carboplatin and paclitaxel in patients with stage IIIB or IV non-small-cell_lung_cancer .
12788050	0	tyrosine	91,99	epidermal_growth_factor_receptor	58,90	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Inhibition of Ca2 + / calmodulin-dependent protein kinase or epidermal_growth_factor_receptor tyrosine kinase abolishes lysophosphatidic_acid-mediated DNA-synthesis in human myometrial smooth muscle cells .
12796031	0	tyrosine	85,93	epidermal_growth_factor_receptor	52,84	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|csubj|Phase Phase|xcomp|trial trial|nmod|END_ENTITY	Phase I pharmacokinetic trial of the selective oral epidermal_growth_factor_receptor tyrosine kinase inhibitor gefitinib -LRB- ` Iressa ' , ZD1839 -RRB- in Japanese patients with solid malignant_tumors .
12810550	0	tyrosine	151,159	epidermal_growth_factor_receptor	118,150	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Extracellular_signal-regulated_kinase_1 / 2 activation by myometrial oxytocin receptor involves Galpha -LRB- q -RRB- Gbetagamma and epidermal_growth_factor_receptor tyrosine kinase activation .
12813135	0	tyrosine	53,61	epidermal_growth_factor_receptor	20,52	tyrosine	epidermal growth factor receptor	CHEBI:18186	13649(Tax:10090)	Chemical	Gene	inhibitor|compound|START_ENTITY inhibitor|compound|END_ENTITY	ZD1839 , a selective epidermal_growth_factor_receptor tyrosine kinase inhibitor , shows antimetastatic activity using a hepatocellular_carcinoma model .
12820772	0	tyrosine	81,89	epidermal_growth_factor_receptor	48,80	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Erlotinib -LRB- Tarceva -RRB- : a promising drug targeting epidermal_growth_factor_receptor tyrosine kinase .
12855618	0	tyrosine	64,72	epidermal_growth_factor_receptor	31,63	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|study study|nmod|END_ENTITY	A pharmacodynamic study of the epidermal_growth_factor_receptor tyrosine kinase inhibitor ZD1839 in metastatic colorectal_cancer patients .
1309297	0	tyrosine	46,54	epidermal_growth_factor_receptor	78,110	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Effect of carboxyl terminal truncation on the tyrosine kinase activity of the epidermal_growth_factor_receptor .
1314948	0	tyrosine	8,16	epidermal_growth_factor_receptor	42,74	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	activities|amod|START_ENTITY activities|nmod|proteins proteins|compound|END_ENTITY	Protein tyrosine kinase activities of the epidermal_growth_factor_receptor and ErbB proteins : correlation of oncogenic activation with altered kinetics .
1323290	0	tyrosine	19,27	epidermal_growth_factor_receptor	129,161	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	residue|compound|START_ENTITY required|nsubjpass|residue required|nmod|activity activity|nmod|END_ENTITY	A highly conserved tyrosine residue at codon 845 within the kinase domain is not required for the transforming activity of human epidermal_growth_factor_receptor .
1381873	0	tyrosine	134,142	epidermal_growth_factor_receptor	87,119	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Development of solid-phase enzyme-linked immunosorbent assays for the determination of epidermal_growth_factor_receptor and pp60c-src tyrosine protein kinase activity .
14506170	0	tyrosine	37,45	epidermal_growth_factor_receptor	4,36	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	ZD1839|amod|START_ENTITY ZD1839|compound|END_ENTITY	The epidermal_growth_factor_receptor tyrosine kinase inhibitor ZD1839 selectively potentiates radiation response of human tumors in nude_mice , with a marked improvement in therapeutic index .
14512423	0	tyrosine	106,114	epidermal_growth_factor_receptor	41,73	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	sites|compound|START_ENTITY induced|nmod|sites END_ENTITY|acl|induced	Ganglioside_GM3 blocks the activation of epidermal_growth_factor_receptor induced by integrin at specific tyrosine sites .
14528090	0	tyrosine	129,137	epidermal_growth_factor_receptor	96,128	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|Enhancement Enhancement|nmod|radiosensitivity radiosensitivity|nmod|cells cells|nmod|ZD1839 ZD1839|appos|END_ENTITY	Enhancement of radiosensitivity in head_and_neck_cancer cells by ZD1839 -LRB- ` IRESSA ' -RRB- , a selective epidermal_growth_factor_receptor tyrosine kinase inhibitor .
14593113	0	tyrosine	140,148	epidermal_growth_factor_receptor	107,139	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The mitogenic action of insulin-like_growth_factor_I in normal human mammary epithelial cells requires the epidermal_growth_factor_receptor tyrosine kinase .
14603528	0	tyrosine	125,133	epidermal_growth_factor_receptor	85,117	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|proliferation proliferation|nmod|apoptosis apoptosis|nmod|cells cells|nmod|END_ENTITY	Inhibition of proliferation and induction of apoptosis in breast_cancer cells by the epidermal_growth_factor_receptor -LRB- EGFR -RRB- tyrosine kinase inhibitor ZD1839 -LRB- ` Iressa ' -RRB- is independent of EGFR expression level .
14607328	0	tyrosine	58,66	epidermal_growth_factor_receptor	25,57	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Gefitinib -LRB- ` Iressa ' -RRB- , an epidermal_growth_factor_receptor tyrosine kinase inhibitor , mediates the inhibition of lymph node metastasis in oral_cancer cells .
14640561	0	tyrosine	103,111	epidermal_growth_factor_receptor	70,102	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Synthesis of a prodrug designed to release multiple inhibitors of the epidermal_growth_factor_receptor tyrosine kinase and an alkylating agent : a novel tumor targeting concept .
14662414	0	tyrosine	66,74	epidermal_growth_factor_receptor	33,65	tyrosine	epidermal growth factor receptor	CHEBI:18186	13649(Tax:10090)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Gefitinib -LRB- ` Iressa ' , ZD1839 -RRB- , an epidermal_growth_factor_receptor tyrosine kinase inhibitor , up-regulates p27KIP1 and induces G1_arrest in oral_squamous_cell_carcinoma cell lines .
1468560	0	tyrosine	60,68	epidermal_growth_factor_receptor	14,46	tyrosine	epidermal growth factor receptor	CHEBI:18186	13649(Tax:10090)	Chemical	Gene	kinase|amod|START_ENTITY functions|nmod|kinase functions|compound|END_ENTITY	Inhibition of epidermal_growth_factor_receptor functions by tyrosine kinase inhibitors in NIH3T3 cells .
14701768	0	tyrosine	82,90	epidermal_growth_factor_receptor	49,81	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|study study|nmod|erlotinib erlotinib|appos|END_ENTITY	Multicenter phase II study of erlotinib , an oral epidermal_growth_factor_receptor tyrosine kinase inhibitor , in patients with recurrent or metastatic squamous_cell_cancer_of_the_head_and_neck .
14703120	0	tyrosine	115,123	epidermal_growth_factor_receptor	75,107	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|3D-QSAR 3D-QSAR|nmod|END_ENTITY	3D-QSAR and docking studies on 4-anilinoquinazoline and 4-anilinoquinoline epidermal_growth_factor_receptor -LRB- EGFR -RRB- tyrosine kinase inhibitors .
14710235	0	tyrosine	67,75	epidermal_growth_factor_receptor	34,66	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|END_ENTITY	Additive antitumour effect of the epidermal_growth_factor_receptor tyrosine kinase inhibitor gefitinib -LRB- Iressa , ZD1839 -RRB- and the antioestrogen fulvestrant -LRB- Faslodex , ICI_182 ,780 -RRB- in breast_cancer cells .
14760089	0	tyrosine	37,45	epidermal_growth_factor_receptor	4,36	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	ZD1839|amod|START_ENTITY ZD1839|amod|END_ENTITY	The epidermal_growth_factor_receptor tyrosine kinase inhibitor ZD1839 -LRB- Iressa -RRB- suppresses c-Src and Pak1 pathways and invasiveness of human cancer cells .
14997040	0	tyrosine	53,61	epidermal_growth_factor_receptor	20,52	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|Evaluation Evaluation|nmod|END_ENTITY	Evaluation of novel epidermal_growth_factor_receptor tyrosine kinase inhibitors .
15035290	0	tyrosine	176,184	epidermal_growth_factor_receptor	143,175	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Inverse correlation of epidermal_growth_factor_receptor messenger RNA induction and suppression of anchorage-independent growth by OSI-774 , an epidermal_growth_factor_receptor tyrosine kinase inhibitor , in glioblastoma_multiforme cell lines .
15035290	0	tyrosine	176,184	epidermal_growth_factor_receptor	23,55	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitor|amod|START_ENTITY OSI-774|appos|inhibitor RNA|nmod|OSI-774 RNA|nsubj|correlation correlation|nmod|messenger messenger|compound|END_ENTITY	Inverse correlation of epidermal_growth_factor_receptor messenger RNA induction and suppression of anchorage-independent growth by OSI-774 , an epidermal_growth_factor_receptor tyrosine kinase inhibitor , in glioblastoma_multiforme cell lines .
15114219	0	tyrosine	19,27	epidermal_growth_factor_receptor	51,83	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|proliferation proliferation|compound|END_ENTITY	Lidocaine inhibits tyrosine kinase activity of the epidermal_growth_factor_receptor and suppresses proliferation of corneal epithelial cells .
15131063	0	tyrosine	14,22	epidermal_growth_factor_receptor	51,83	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nmod|III III|compound|END_ENTITY	Resistance to tyrosine kinase inhibition by mutant epidermal_growth_factor_receptor variant III contributes to the neoplastic phenotype of glioblastoma multiforme .
15135307	0	tyrosine	58,66	epidermal_growth_factor_receptor	25,57	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Transinactivation of the epidermal_growth_factor_receptor tyrosine kinase and focal_adhesion_kinase phosphorylation by dietary flavonoids : effect on invasive potential of human carcinoma cells .
15171693	0	tyrosine	90,98	epidermal_growth_factor_receptor	129,161	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|acl|signaling signaling|nmod|END_ENTITY	Human milk induces fetal small intestinal cell proliferation - involvement of a different tyrosine kinase signaling pathway from epidermal_growth_factor_receptor .
15186837	0	tyrosine	105,113	epidermal_growth_factor_receptor	54,86	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Benzamides and benzamidines as specific inhibitors of epidermal_growth_factor_receptor and v-Src protein tyrosine kinases .
15269164	0	tyrosine	80,88	epidermal_growth_factor_receptor	47,79	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|Evaluation Evaluation|nmod|potential potential|nmod|END_ENTITY	Evaluation of the therapeutic potential of the epidermal_growth_factor_receptor tyrosine kinase inhibitor gefitinib in preclinical models of bladder_cancer .
15289342	0	tyrosine	113,121	epidermal_growth_factor_receptor	38,70	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitor|amod|START_ENTITY combining|nmod|inhibitor targeting|parataxis|combining targeting|nmod|END_ENTITY	Dual-agent molecular targeting of the epidermal_growth_factor_receptor -LRB- EGFR -RRB- : combining anti-EGFR antibody with tyrosine kinase inhibitor .
15355926	0	tyrosine	58,66	epidermal_growth_factor_receptor	25,57	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	targeting|dep|START_ENTITY targeting|dobj|END_ENTITY	Simultaneously targeting epidermal_growth_factor_receptor tyrosine kinase and cyclooxygenase-2 , an efficient approach to inhibition of squamous_cell_carcinoma_of_the_head_and_neck .
15475436	0	tyrosine	61,69	epidermal_growth_factor_receptor	9,41	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	gefitinib|amod|START_ENTITY END_ENTITY|nmod|gefitinib	Combined epidermal_growth_factor_receptor targeting with the tyrosine kinase inhibitor gefitinib -LRB- ZD1839 -RRB- and the monoclonal antibody cetuximab -LRB- IMC-C225 -RRB- : superiority over single-agent receptor targeting .
15570011	0	tyrosine	121,129	epidermal_growth_factor_receptor	88,120	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	gefitinib|compound|START_ENTITY gefitinib|compound|END_ENTITY	Deregulated cyclin_D1 expression is associated with decreased efficacy of the selective epidermal_growth_factor_receptor tyrosine kinase inhibitor gefitinib in head_and_neck_squamous_cell_carcinoma cell lines .
15571862	0	tyrosine	99,107	epidermal_growth_factor_receptor	66,98	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinase|amod|START_ENTITY kinase|amod|4-Anilinoquinazolines 4-Anilinoquinazolines|advcl|Lavendustin Lavendustin|nmod|inhibitors inhibitors|nmod|END_ENTITY	4-Anilinoquinazolines with Lavendustin A subunit as inhibitors of epidermal_growth_factor_receptor tyrosine kinase : syntheses , chemical and pharmacological properties .
15611794	0	tyrosine	104,112	epidermal_growth_factor_receptor	71,103	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|radiosensitisation radiosensitisation|nmod|ZD1839 ZD1839|appos|END_ENTITY	Differential radiosensitisation by ZD1839 -LRB- Iressa -RRB- , a highly selective epidermal_growth_factor_receptor tyrosine kinase inhibitor in two related bladder_cancer cell lines .
15638953	0	tyrosine	71,79	epidermal_growth_factor_receptor	38,70	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|data data|nmod|END_ENTITY	Phase II clinical trial data with the epidermal_growth_factor_receptor tyrosine kinase inhibitor erlotinib -LRB- OSI-774 -RRB- in non-small-cell_lung_cancer .
15638956	0	tyrosine	105,113	epidermal_growth_factor_receptor	10,42	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY epidermal_growth_factor_receptor|dobj|inhibitors response|acl|epidermal_growth_factor_receptor mutations|nmod|response mutations|compound|END_ENTITY	Effect of epidermal_growth_factor_receptor mutations on the response to epidermal_growth_factor_receptor tyrosine kinase inhibitors : target-based populations for target-based drugs .
15638956	0	tyrosine	105,113	epidermal_growth_factor_receptor	72,104	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY END_ENTITY|dobj|inhibitors	Effect of epidermal_growth_factor_receptor mutations on the response to epidermal_growth_factor_receptor tyrosine kinase inhibitors : target-based populations for target-based drugs .
15641030	0	tyrosine	23,31	epidermal_growth_factor_receptor	40,72	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinases|compound|START_ENTITY kinases|amod|END_ENTITY	Expression of receptor tyrosine kinases epidermal_growth_factor_receptor and HER-2 / neu in synovial_sarcoma .
15688607	0	tyrosine	48,56	epidermal_growth_factor_receptor	15,47	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Small molecule epidermal_growth_factor_receptor tyrosine kinase inhibitors : an overview .
15735043	0	tyrosine	66,74	epidermal_growth_factor_receptor	33,65	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Gefitinib -LRB- `` Iressa '' , ZD1839 -RRB- , an epidermal_growth_factor_receptor tyrosine kinase inhibitor , reverses breast_cancer_resistance_protein / ABCG2-mediated drug resistance .
15753462	0	tyrosine	167,175	epidermal_growth_factor_receptor	134,166	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitor|compound|START_ENTITY inhibitor|compound|END_ENTITY	Phase I/II trial evaluating the anti-vascular_endothelial_growth_factor monoclonal antibody bevacizumab in combination with the HER-1 / epidermal_growth_factor_receptor tyrosine kinase inhibitor erlotinib for patients with recurrent non-small-cell_lung_cancer .
15788655	0	tyrosine	17,25	epidermal_growth_factor_receptor	47,79	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	domain|amod|START_ENTITY Mutations|nmod|domain Mutations|nmod|END_ENTITY	Mutations in the tyrosine kinase domain of the epidermal_growth_factor_receptor in non-small_cell_lung_cancer .
15827338	0	tyrosine	77,85	epidermal_growth_factor_receptor	44,76	tyrosine	epidermal growth factor receptor	CHEBI:18186	13649(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|penetration penetration|nmod|gefitinib gefitinib|appos|END_ENTITY	Tumor penetration of gefitinib -LRB- Iressa -RRB- , an epidermal_growth_factor_receptor tyrosine kinase inhibitor .
15842252	0	tyrosine	67,75	epidermal_growth_factor_receptor	34,66	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|ZD1839 ZD1839|appos|END_ENTITY	The effect of ZD1839 -LRB- Iressa -RRB- , an epidermal_growth_factor_receptor tyrosine kinase inhibitor , in combination with cisplatin , on apoptosis in SCC-15 cells .
15897572	0	tyrosine	16,24	epidermal_growth_factor_receptor	42,74	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Mutation in the tyrosine kinase domain of epidermal_growth_factor_receptor is a predictive and prognostic factor for gefitinib treatment in patients with non-small_cell_lung_cancer .
15899817	0	tyrosine	92,100	epidermal_growth_factor_receptor	59,91	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	HER2 overexpression increases sensitivity to gefitinib , an epidermal_growth_factor_receptor tyrosine kinase inhibitor , through inhibition of HER2/HER3 heterodimer formation in lung_cancer cells .
15915001	0	tyrosine	108,116	epidermal_growth_factor_receptor	75,107	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Diabetes-induced_renal_vascular_dysfunction is normalized by inhibition of epidermal_growth_factor_receptor tyrosine kinase .
15951569	0	tyrosine	35,43	epidermal_growth_factor_receptor	73,105	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	sites|amod|START_ENTITY sites|nmod|END_ENTITY	Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal_growth_factor_receptor signaling network reveals dynamic modules .
15958609	0	tyrosine	70,78	epidermal_growth_factor_receptor	37,69	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|mutations mutations|nmod|END_ENTITY	Gefitinib-sensitive mutations of the epidermal_growth_factor_receptor tyrosine kinase domain in chinese patients with non-small cell lung_cancer .
16115929	0	tyrosine	28,36	epidermal_growth_factor_receptor	58,90	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Activating mutations in the tyrosine kinase domain of the epidermal_growth_factor_receptor are associated with improved survival in gefitinib-treated chemorefractory_lung_adenocarcinomas .
16174225	0	tyrosine	86,94	epidermal_growth_factor_receptor	41,73	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitor|amod|START_ENTITY erlotinib_HCl|dep|inhibitor erlotinib_HCl|appos|END_ENTITY	Efficacy and safety of erlotinib_HCl , an epidermal_growth_factor_receptor -LRB- HER1/EGFR -RRB- tyrosine kinase inhibitor , in patients with advanced ovarian_carcinoma : results from a phase II multicenter study .
16203806	0	tyrosine	147,155	epidermal_growth_factor_receptor	87,119	tyrosine	epidermal growth factor receptor	D014443	1956	Chemical	Gene	START_ENTITY|nsubj|efficacy efficacy|nmod|radioimmunotherapy radioimmunotherapy|nmod|90Y-CHX-A 90Y-CHX-A|amod|DTPA-hu3S193 DTPA-hu3S193|nmod|inhibition inhibition|nmod|END_ENTITY	Enhanced efficacy of radioimmunotherapy with 90Y-CHX-A '' - DTPA-hu3S193 by inhibition of epidermal_growth_factor_receptor -LRB- EGFR -RRB- signaling with EGFR tyrosine kinase inhibitor AG1478 .
16222152	0	tyrosine	37,45	epidermal_growth_factor_receptor	4,36	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	gefitinib|amod|START_ENTITY gefitinib|compound|END_ENTITY	The epidermal_growth_factor_receptor tyrosine kinase inhibitor gefitinib sensitizes colon_cancer cells to irinotecan .
16279804	0	tyrosine	72,80	epidermal_growth_factor_receptor	39,71	tyrosine	epidermal growth factor receptor	CHEBI:18186	13649(Tax:10090)	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Anilinodialkoxyquinazolines : screening epidermal_growth_factor_receptor tyrosine kinase inhibitors for potential tumor imaging probes .
16299242	0	tyrosine	75,83	epidermal_growth_factor_receptor	42,74	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY END_ENTITY|dobj|inhibitors	Response of some head_and_neck_cancers to epidermal_growth_factor_receptor tyrosine kinase inhibitors may be linked to mutation of ERBB2 rather than EGFR .
16336751	0	tyrosine	33,41	epidermal_growth_factor_receptor	70,102	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY status|nmod|kinase inhibitors|nsubj|status inhibitors|xcomp|targeting targeting|dobj|END_ENTITY	Current status of small-molecule tyrosine kinase inhibitors targeting epidermal_growth_factor_receptor in colorectal_cancer .
16380971	0	tyrosine	52,60	epidermal_growth_factor_receptor	82,114	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	domain|amod|START_ENTITY flanking|dobj|domain flanking|nmod|END_ENTITY	Electrostatic interactions of peptides flanking the tyrosine kinase domain in the epidermal_growth_factor_receptor provides a model for intracellular dimerization and autophosphorylation .
16428508	0	tyrosine	67,75	epidermal_growth_factor_receptor	34,66	tyrosine	epidermal growth factor receptor	CHEBI:18186	13649(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|activity activity|nmod|END_ENTITY	Synergistic antitumor activity of epidermal_growth_factor_receptor tyrosine kinase inhibitor gefitinib and IFN-alpha in head_and_neck_cancer cells in vitro and in vivo .
1645724	0	tyrosine	12,20	epidermal_growth_factor_receptor	98,130	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	activity|amod|START_ENTITY role|nmod|activity role|nmod|END_ENTITY	The role of tyrosine kinase activity in endocytosis , compartmentation , and down-regulation of the epidermal_growth_factor_receptor .
16459174	0	tyrosine	63,71	epidermal_growth_factor_receptor	30,62	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|studies studies|nmod|END_ENTITY	Ongoing first-line studies of epidermal_growth_factor_receptor tyrosine kinase inhibitors in select patient populations .
16682734	0	tyrosine	67,75	epidermal_growth_factor_receptor	34,66	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY END_ENTITY|dobj|inhibitors	Ethnic differences in response to epidermal_growth_factor_receptor tyrosine kinase inhibitors .
16778092	0	tyrosine	105,113	epidermal_growth_factor_receptor	72,104	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|markers markers|nmod|selection selection|nmod|END_ENTITY	Biological markers for non-small_cell_lung_cancer patient selection for epidermal_growth_factor_receptor tyrosine kinase inhibitor therapy .
16778591	0	tyrosine	71,79	epidermal_growth_factor_receptor	101,133	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	detecting|nmod|START_ENTITY method|acl|detecting kinase|nsubj|method kinase|dobj|domain domain|nmod|gene gene|compound|END_ENTITY	A simple and sensitive method for detecting major mutations within the tyrosine kinase domain of the epidermal_growth_factor_receptor gene in non-small-cell_lung_carcinoma .
16796793	0	tyrosine	81,89	epidermal_growth_factor_receptor	48,80	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|Efficacy Efficacy|nmod|cetuximab cetuximab|nmod|treatment treatment|nmod|END_ENTITY	Efficacy of cetuximab after treatment with oral epidermal_growth_factor_receptor tyrosine kinase inhibitor-based chemotherapy in metastatic colorectal_cancer .
16799022	0	tyrosine	11,19	epidermal_growth_factor_receptor	57,89	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinases|nsubj|START_ENTITY kinases|nmod|activation activation|compound|END_ENTITY	SRC-family tyrosine kinases in wound - and ligand-induced epidermal_growth_factor_receptor activation in human corneal epithelial cells .
16820093	0	tyrosine	151,159	epidermal_growth_factor_receptor	15,47	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY therapy|nmod|inhibitors target|nmod|therapy target|nsubj|END_ENTITY	Phosphorylated epidermal_growth_factor_receptor on tumor-associated endothelial cells in human renal_cell_carcinoma is a primary target for therapy by tyrosine kinase inhibitors .
16820093	1	tyrosine	341,349	epidermal_growth_factor_receptor	301,333	tyrosine	transforming growth factor alpha	CHEBI:18186	7124	Chemical	Gene	START_ENTITY|nsubj|therapy therapy|nmod|renal_cell_carcinoma renal_cell_carcinoma|acl:relcl|grows grows|nmod|END_ENTITY	We determined whether therapy for human renal_cell_carcinoma -LRB- HRCC -RRB- that grows in the kidney of nude_mice by the specific epidermal_growth_factor_receptor -LRB- EGFR -RRB- tyrosine kinase inhibitor , PKI166 , is directed against phosphorylated EGFR on tumor cells or on tumor-associated endothelial cells .
16857820	0	tyrosine	181,189	epidermal_growth_factor_receptor	10,42	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitors|compound|START_ENTITY treated|nmod|inhibitors non-small_cell_lung_cancer|acl|treated tyrosine|nmod|non-small_cell_lung_cancer tyrosine|nsubj|Effect Effect|nmod|END_ENTITY	Effect of epidermal_growth_factor_receptor tyrosine kinase domain mutations on the outcome of patients with non-small_cell_lung_cancer treated with epidermal_growth_factor_receptor tyrosine kinase inhibitors .
16857820	0	tyrosine	181,189	epidermal_growth_factor_receptor	148,180	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Effect of epidermal_growth_factor_receptor tyrosine kinase domain mutations on the outcome of patients with non-small_cell_lung_cancer treated with epidermal_growth_factor_receptor tyrosine kinase inhibitors .
16857820	0	tyrosine	43,51	epidermal_growth_factor_receptor	10,42	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of epidermal_growth_factor_receptor tyrosine kinase domain mutations on the outcome of patients with non-small_cell_lung_cancer treated with epidermal_growth_factor_receptor tyrosine kinase inhibitors .
16857820	0	tyrosine	43,51	epidermal_growth_factor_receptor	148,180	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nmod|non-small_cell_lung_cancer non-small_cell_lung_cancer|acl|treated treated|nmod|inhibitors inhibitors|compound|END_ENTITY	Effect of epidermal_growth_factor_receptor tyrosine kinase domain mutations on the outcome of patients with non-small_cell_lung_cancer treated with epidermal_growth_factor_receptor tyrosine kinase inhibitors .
1688559	0	tyrosine	119,127	epidermal_growth_factor_receptor	54,86	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	992|amod|START_ENTITY reveals|nmod|992 reveals|nsubj|Analysis Analysis|nmod|deletions deletions|nmod|terminus terminus|nmod|END_ENTITY	Analysis of deletions of the carboxyl terminus of the epidermal_growth_factor_receptor reveals self-phosphorylation at tyrosine 992 and enhanced in vivo tyrosine phosphorylation of cell substrates .
16891461	0	tyrosine	46,54	epidermal_growth_factor_receptor	13,45	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of an epidermal_growth_factor_receptor tyrosine kinase inhibitor on actin remodeling in an in vitro bladder_cancer carcinogenesis model .
16912195	0	tyrosine	145,153	epidermal_growth_factor_receptor	112,144	tyrosine	epidermal growth factor receptor	CHEBI:18186	13649(Tax:10090)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Kinetic analysis of epidermal_growth_factor_receptor somatic mutant proteins shows increased sensitivity to the epidermal_growth_factor_receptor tyrosine kinase inhibitor , erlotinib .
16912195	0	tyrosine	145,153	epidermal_growth_factor_receptor	20,52	tyrosine	epidermal growth factor receptor	CHEBI:18186	13649(Tax:10090)	Chemical	Gene	inhibitor|amod|START_ENTITY shows|nmod|inhibitor shows|nsubj|analysis analysis|nmod|proteins proteins|amod|END_ENTITY	Kinetic analysis of epidermal_growth_factor_receptor somatic mutant proteins shows increased sensitivity to the epidermal_growth_factor_receptor tyrosine kinase inhibitor , erlotinib .
16940802	0	tyrosine	86,94	epidermal_growth_factor_receptor	53,85	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|Identification Identification|nmod|combinations combinations|nmod|END_ENTITY	Identification of potentially useful combinations of epidermal_growth_factor_receptor tyrosine kinase antagonists with conventional cytotoxic agents using median effect analysis .
16943190	0	tyrosine	4,12	epidermal_growth_factor_receptor	49,81	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY regulates|nsubj|kinase regulates|dobj|endocytosis endocytosis|nmod|END_ENTITY	Abl tyrosine kinase regulates endocytosis of the epidermal_growth_factor_receptor .
17096850	0	tyrosine	86,94	epidermal_growth_factor_receptor	53,85	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY END_ENTITY|dobj|inhibitors	Gene expression patterns that predict sensitivity to epidermal_growth_factor_receptor tyrosine kinase inhibitors in lung_cancer cell lines and human lung_tumors .
17145836	0	tyrosine	66,74	epidermal_growth_factor_receptor	26,58	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|activity activity|nmod|END_ENTITY	Antitumor activity of the epidermal_growth_factor_receptor -LRB- EGFR -RRB- tyrosine kinase inhibitor gefitinib -LRB- ZD1839 , Iressa -RRB- in non-small_cell_lung_cancer cell lines correlates with gene copy number and EGFR mutations but not EGFR protein levels .
17236550	0	tyrosine	66,74	epidermal_growth_factor_receptor	33,65	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|study study|nmod|effect effect|nmod|END_ENTITY	-LSB- Experimental study of effect of epidermal_growth_factor_receptor tyrosine kinase inhibitor ZD1839 in combination with irinotecan -RSB- .
17239288	0	tyrosine	75,83	epidermal_growth_factor_receptor	42,74	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	therapy|amod|START_ENTITY therapy|compound|END_ENTITY	Interstitial_lung_disease associated with epidermal_growth_factor_receptor tyrosine kinase inhibitor therapy in non-small-cell_lung_carcinoma .
1729595	0	tyrosine	10,18	epidermal_growth_factor_receptor	60,92	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|terminus terminus|nmod|END_ENTITY	A site of tyrosine phosphorylation in the C terminus of the epidermal_growth_factor_receptor is required to activate phospholipase C. Cells expressing mutant epidermal growth factor -LRB- EGF -RRB- receptors have been used to study mechanisms through which EGF increases phospholipase C -LRB- PLC -RRB- activity .
17296817	0	tyrosine	85,93	epidermal_growth_factor_receptor	52,84	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY END_ENTITY|dobj|inhibitors	Understanding the new genetics of responsiveness to epidermal_growth_factor_receptor tyrosine kinase inhibitors .
17381163	0	tyrosine	129,137	epidermal_growth_factor_receptor	10,42	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	sensitive|xcomp|START_ENTITY cells|acl:relcl|sensitive microclusters|nmod|cells forms|nmod|microclusters forms|nsubj|END_ENTITY	Unligated epidermal_growth_factor_receptor forms higher order oligomers within microclusters on A431 cells that are sensitive to tyrosine kinase inhibitor binding .
17404024	0	tyrosine	37,45	epidermal_growth_factor_receptor	4,36	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	ZD1839|amod|START_ENTITY ZD1839|amod|END_ENTITY	The epidermal_growth_factor_receptor tyrosine kinase inhibitor ZD1839 -LRB- Iressa -RRB- suppresses proliferation and invasion of human oral squamous_carcinoma cells via p53 independent and MMP , uPAR dependent mechanism .
17409937	0	tyrosine	97,105	epidermal_growth_factor_receptor	64,96	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Is the importance of achieving stable disease different between epidermal_growth_factor_receptor tyrosine kinase inhibitors and cytotoxic agents in the second-line setting for advanced non-small_cell_lung_cancer ?
17409961	0	tyrosine	52,60	epidermal_growth_factor_receptor	112,144	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	mutations|amod|START_ENTITY significance|nmod|mutations significance|nmod|END_ENTITY	Clinico-pathological and biological significance of tyrosine kinase domain gene mutations and overexpression of epidermal_growth_factor_receptor for lung_adenocarcinoma .
17456787	0	tyrosine	57,65	epidermal_growth_factor_receptor	24,56	tyrosine	epidermal growth factor receptor	D014443	1956	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Erlotinib , an effective epidermal_growth_factor_receptor tyrosine kinase inhibitor , induces p27KIP1 up-regulation and nuclear translocation in association with cell growth inhibition and G1/S phase arrest in human non-small-cell_lung_cancer cell lines .
17504988	0	tyrosine	103,111	epidermal_growth_factor_receptor	70,102	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	KRAS mutation is an important predictor of resistance to therapy with epidermal_growth_factor_receptor tyrosine kinase inhibitors in non-small-cell_lung_cancer .
17545606	0	tyrosine	25,33	epidermal_growth_factor_receptor	51,83	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Somatic mutations in the tyrosine kinase domain of epidermal_growth_factor_receptor -LRB- EGFR -RRB- abrogate EGFR-mediated radioprotection in non-small_cell_lung_carcinoma .
17551144	0	tyrosine	141,149	epidermal_growth_factor_receptor	108,140	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Mass spectrometry to classify non-small-cell_lung_cancer patients for clinical outcome after treatment with epidermal_growth_factor_receptor tyrosine kinase inhibitors : a multicohort cross-institutional study .
17606725	0	tyrosine	115,123	epidermal_growth_factor_receptor	82,114	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	erlotinib|amod|START_ENTITY erlotinib|amod|END_ENTITY	Correlation between development of rash and efficacy in patients treated with the epidermal_growth_factor_receptor tyrosine kinase inhibitor erlotinib in two large phase III studies .
17711504	0	tyrosine	133,141	epidermal_growth_factor_receptor	100,132	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	GM3_synthase gene is a novel biomarker for histological classification and drug sensitivity against epidermal_growth_factor_receptor tyrosine kinase inhibitors in non-small cell lung_cancer .
17804114	0	tyrosine	139,147	epidermal_growth_factor_receptor	106,138	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Exacerbated radiodermatitis and bilateral subdural_hemorrhage after whole brain irradiation combined with epidermal_growth_factor_receptor tyrosine kinase inhibitors for brain metastases in lung_cancer .
17888036	0	tyrosine	125,133	epidermal_growth_factor_receptor	92,124	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Mutations of the epidermal_growth_factor_receptor gene and related genes as determinants of epidermal_growth_factor_receptor tyrosine kinase inhibitors sensitivity in lung_cancer .
17945377	0	tyrosine	74,82	epidermal_growth_factor_receptor	41,73	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY END_ENTITY|dobj|inhibitors	Subsequent brain_metastasis responses to epidermal_growth_factor_receptor tyrosine kinase inhibitors in a patient with non-small-cell_lung_cancer .
18187583	0	tyrosine	110,118	epidermal_growth_factor_receptor	77,109	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Molecular mechanisms underlying the synergistic interaction of erlotinib , an epidermal_growth_factor_receptor tyrosine kinase inhibitor , with the multitargeted antifolate pemetrexed in non-small-cell_lung_cancer cells .
18317068	0	tyrosine	118,126	epidermal_growth_factor_receptor	23,55	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinase|amod|START_ENTITY inhibitor|amod|kinase inhibition|appos|inhibitor inhibition|nmod|END_ENTITY	Dual inhibition of the epidermal_growth_factor_receptor with cetuximab , an IgG1 monoclonal antibody , and gefitinib , a tyrosine kinase inhibitor , in patients with refractory non-small_cell_lung_cancer -LRB- NSCLC -RRB- : a phase I study .
1845982	0	tyrosine	124,132	epidermal_growth_factor_receptor	55,87	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	activity|amod|START_ENTITY effects|nmod|activity results|nmod|effects results|nsubj|Autophosphorylation Autophosphorylation|nmod|domain domain|nmod|END_ENTITY	Autophosphorylation of the intracellular domain of the epidermal_growth_factor_receptor results in different effects on its tyrosine kinase activity with various peptide substrates .
18472966	0	tyrosine	123,131	epidermal_growth_factor_receptor	15,47	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY therapy|nmod|inhibitors target|nmod|therapy target|nsubj|END_ENTITY	Phosphorylated epidermal_growth_factor_receptor on tumor-associated endothelial cells is a primary target for therapy with tyrosine kinase inhibitors .
18483355	0	tyrosine	70,78	epidermal_growth_factor_receptor	37,69	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|Mechanisms Mechanisms|nmod|resistance resistance|nmod|END_ENTITY	Mechanisms of acquired resistance to epidermal_growth_factor_receptor tyrosine kinase inhibitors in non-small_cell_lung_cancer .
18670300	0	tyrosine	25,33	epidermal_growth_factor_receptor	51,83	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Somatic mutations of the tyrosine kinase domain of epidermal_growth_factor_receptor and tyrosine kinase inhibitor response to TKIs in non-small_cell_lung_cancer : an analytical database .
18754874	0	tyrosine	138,146	epidermal_growth_factor_receptor	105,137	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitor|amod|START_ENTITY END_ENTITY|dobj|inhibitor	N-Glycan fucosylation of epidermal_growth_factor_receptor modulates receptor activity and sensitivity to epidermal_growth_factor_receptor tyrosine kinase inhibitor .
18754874	0	tyrosine	138,146	epidermal_growth_factor_receptor	25,57	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitor|amod|START_ENTITY epidermal_growth_factor_receptor|dobj|inhibitor modulates|advcl|epidermal_growth_factor_receptor modulates|nsubj|fucosylation fucosylation|nmod|END_ENTITY	N-Glycan fucosylation of epidermal_growth_factor_receptor modulates receptor activity and sensitivity to epidermal_growth_factor_receptor tyrosine kinase inhibitor .
18757423	0	tyrosine	78,86	epidermal_growth_factor_receptor	35,67	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitor|amod|START_ENTITY neu|dobj|inhibitor neu|nsubj|inhibition inhibition|nmod|END_ENTITY	Synergistic inhibition with a dual epidermal_growth_factor_receptor / HER-2 / neu tyrosine kinase inhibitor and a disintegrin and metalloprotease inhibitor .
18794807	0	tyrosine	18,26	epidermal_growth_factor_receptor	135,167	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinase|amod|START_ENTITY Inhibition|nmod|kinase reverts|nsubj|Inhibition reverts|dobj|chemoresistance chemoresistance|dep|involvement involvement|nmod|END_ENTITY	Inhibition of Src tyrosine kinase reverts chemoresistance toward 5-fluorouracil in human pancreatic_carcinoma cells : an involvement of epidermal_growth_factor_receptor signaling .
18803986	0	tyrosine	70,78	epidermal_growth_factor_receptor	37,69	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Lapatinib : a dual inhibitor of human epidermal_growth_factor_receptor tyrosine kinases .
18998063	0	tyrosine	36,44	epidermal_growth_factor_receptor	66,98	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Novel and existing mutations in the tyrosine kinase domain of the epidermal_growth_factor_receptor are predictors of optimal resectability in malignant_peritoneal_mesothelioma .
19024103	0	tyrosine	63,71	epidermal_growth_factor_receptor	30,62	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Antitumor activity of F90 , an epidermal_growth_factor_receptor tyrosine kinase inhibitor , on glioblastoma cell line SHG-44 .
19056486	0	tyrosine	92,100	epidermal_growth_factor_receptor	23,55	tyrosine	epidermal growth factor receptor	CHEBI:18186	13649(Tax:10090)	Chemical	Gene	activity|compound|START_ENTITY mechanism|nmod|activity S-Nitrosylation|dep|mechanism S-Nitrosylation|nmod|END_ENTITY	S-Nitrosylation of the epidermal_growth_factor_receptor : a regulatory mechanism of receptor tyrosine kinase activity .
19088172	0	tyrosine	112,120	epidermal_growth_factor_receptor	14,46	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	metastatic_tumors|nmod|START_ENTITY mutations|nmod|metastatic_tumors mutations|compound|END_ENTITY	Comparison of epidermal_growth_factor_receptor mutations between primary and corresponding metastatic_tumors in tyrosine kinase inhibitor-naive non-small-cell lung_cancer .
19133013	0	tyrosine	80,88	epidermal_growth_factor_receptor	32,64	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	992|amod|START_ENTITY site|nmod|992 END_ENTITY|nmod|site	Enhanced phosphorylation of the epidermal_growth_factor_receptor at the site of tyrosine 992 in esophageal_carcinomas .
1913853	0	tyrosine	18,26	epidermal_growth_factor_receptor	64,96	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|dobj|domain domain|nmod|fraction fraction|nmod|molecules molecules|compound|END_ENTITY	Evidence that the tyrosine kinase domain of a small fraction of epidermal_growth_factor_receptor molecules is exposed on the outer surface of A431 cells .
19154417	0	tyrosine	163,171	epidermal_growth_factor_receptor	130,162	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitor|amod|START_ENTITY END_ENTITY|dobj|inhibitor	Epidermal_growth_factor_receptor lacking C-terminal autophosphorylation sites retains signal transduction and high sensitivity to epidermal_growth_factor_receptor tyrosine kinase inhibitor .
19197951	0	tyrosine	61,69	epidermal_growth_factor_receptor	28,60	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|Determinants Determinants|nmod|response response|nmod|END_ENTITY	Determinants of response to epidermal_growth_factor_receptor tyrosine kinase inhibition in squamous_cell_carcinoma_of_the_head_and_neck .
19229369	0	tyrosine	49,57	epidermal_growth_factor_receptor	16,48	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	The role of the epidermal_growth_factor_receptor tyrosine kinase inhibitors as therapy for advanced , metastatic , and recurrent non-small-cell_lung_cancer : a Canadian national consensus statement .
19288574	0	tyrosine	66,74	epidermal_growth_factor_receptor	33,65	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Genistein enhances the effect of epidermal_growth_factor_receptor tyrosine kinase inhibitors and inhibits nuclear_factor_kappa_B in nonsmall_cell_lung_cancer cell lines .
19342999	0	tyrosine	75,83	epidermal_growth_factor_receptor	42,74	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Enediyne lidamycin enhances the effect of epidermal_growth_factor_receptor tyrosine kinase inhibitor , gefitinib , in epidermoid_carcinoma A431 cells and lung_carcinoma H460 cells .
19349511	0	tyrosine	137,145	epidermal_growth_factor_receptor	97,129	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinases|amod|START_ENTITY END_ENTITY|dep|kinases	Vandetanib -LRB- ZD6474 -RRB- , a dual inhibitor of vascular_endothelial_growth_factor_receptor -LRB- VEGFR -RRB- and epidermal_growth_factor_receptor -LRB- EGFR -RRB- tyrosine kinases : current status and future directions .
19596948	0	tyrosine	92,100	epidermal_growth_factor_receptor	59,91	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Biological and clinical features in predicting efficacy of epidermal_growth_factor_receptor tyrosine kinase inhibitors : a systematic review and meta-analysis .
19620791	0	tyrosine	16,24	epidermal_growth_factor_receptor	46,78	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|dobj|inhibitors inhibitors|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Small-molecule tyrosine kinase inhibitors of epidermal_growth_factor_receptor -LRB- EGFR -RRB- -RSB- .
19632948	0	tyrosine	56,64	epidermal_growth_factor_receptor	131,163	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|xcomp|dependent dependent|nmod|pathway pathway|compound|END_ENTITY	Acquired resistance to epidermal_growth_factor_receptor tyrosine kinase inhibitors in non-small-cell_lung_cancers dependent on the epidermal_growth_factor_receptor pathway .
19632948	0	tyrosine	56,64	epidermal_growth_factor_receptor	23,55	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|resistance resistance|nmod|END_ENTITY	Acquired resistance to epidermal_growth_factor_receptor tyrosine kinase inhibitors in non-small-cell_lung_cancers dependent on the epidermal_growth_factor_receptor pathway .
1972062	0	tyrosine	15,23	epidermal_growth_factor_receptor	58,90	tyrosine	epidermal growth factor receptor	CHEBI:18186	37455(Tax:7227)	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Enhancement of tyrosine kinase activity of the Drosophila epidermal_growth_factor_receptor homolog by alterations of the transmembrane domain .
1974718	0	tyrosine	104,112	epidermal_growth_factor_receptor	4,36	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	cascade|compound|START_ENTITY members|nmod|cascade members|nsubj|END_ENTITY	The epidermal_growth_factor_receptor and the product of the neu protooncogene are members of a receptor tyrosine phosphorylation cascade .
19807095	0	tyrosine	153,161	epidermal_growth_factor_receptor	35,67	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	activity|compound|START_ENTITY inhibition|nmod|activity associated|nmod|inhibition associated|nsubjpass|activation activation|nmod|END_ENTITY	Sustained activation of glial cell epidermal_growth_factor_receptor by bis -LRB- thiosemicarbazonato -RRB- metal complexes is associated with inhibition of protein tyrosine phosphatase activity .
19843665	0	tyrosine	103,111	epidermal_growth_factor_receptor	70,102	tyrosine	epidermal growth factor receptor	CHEBI:18186	13649(Tax:10090)	Chemical	Gene	inhibitors|amod|START_ENTITY END_ENTITY|dobj|inhibitors	Crosstalk to stromal fibroblasts induces resistance of lung_cancer to epidermal_growth_factor_receptor tyrosine kinase inhibitors .
19861462	0	tyrosine	78,86	epidermal_growth_factor_receptor	29,61	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	receptors|amod|START_ENTITY membrane|dobj|receptors membrane|nsubj|translocation translocation|nmod|family family|compound|END_ENTITY	Nuclear translocation of the epidermal_growth_factor_receptor family membrane tyrosine kinase receptors .
1988447	0	tyrosine	77,85	epidermal_growth_factor_receptor	44,76	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Antibody-induced dimerization activates the epidermal_growth_factor_receptor tyrosine kinase .
19943320	0	tyrosine	85,93	epidermal_growth_factor_receptor	52,84	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Diabetes and microvascular pathophysiology : role of epidermal_growth_factor_receptor tyrosine kinase .
19949011	0	tyrosine	79,87	epidermal_growth_factor_receptor	46,78	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|definition definition|nmod|resistance resistance|nmod|END_ENTITY	Clinical definition of acquired resistance to epidermal_growth_factor_receptor tyrosine kinase inhibitors in non-small-cell_lung_cancer .
20088749	0	tyrosine	75,83	epidermal_growth_factor_receptor	42,74	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitor|amod|START_ENTITY END_ENTITY|dep|inhibitor	A review of erlotinib -- an oral , selective epidermal_growth_factor_receptor tyrosine kinase inhibitor .
20110044	0	tyrosine	119,127	epidermal_growth_factor_receptor	41,73	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Lapatinib : a small-molecule inhibitor of epidermal_growth_factor_receptor and human epidermal_growth_factor_receptor-2 tyrosine kinases used in the treatment of breast_cancer .
20139181	0	tyrosine	125,133	epidermal_growth_factor_receptor	92,124	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Hypoxia-induced proliferation of human pulmonary microvascular endothelial cells depends on epidermal_growth_factor_receptor tyrosine kinase activation .
20195171	0	tyrosine	111,119	epidermal_growth_factor_receptor	78,110	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinase|amod|START_ENTITY END_ENTITY|dobj|kinase	Osteoblastic reaction in non-small_cell_lung_carcinoma and its association to epidermal_growth_factor_receptor tyrosine kinase inhibitors response and prolonged survival .
2025882	0	tyrosine	47,55	epidermal_growth_factor_receptor	14,46	tyrosine	epidermal growth factor receptor	CHEBI:18186	13649(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Modulation Modulation|nmod|END_ENTITY	Modulation of epidermal_growth_factor_receptor tyrosine phosphorylation by tumor_necrosis_factor .
20407013	0	tyrosine	14,22	epidermal_growth_factor_receptor	91,123	tyrosine	epidermal growth factor receptor	CHEBI:18186	13649(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY Activation|nmod|phosphorylation kinase|nsubj|Activation kinase|xcomp|mediate mediate|dobj|END_ENTITY	Activation by tyrosine phosphorylation as a prerequisite for protein kinase C to mediate epidermal_growth_factor_receptor signaling to ERK .
20583855	0	tyrosine	152,160	epidermal_growth_factor_receptor	112,144	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Synthesis and antiproliferative activities against Hep-G2 of salicylanide derivatives : potent inhibitors of the epidermal_growth_factor_receptor -LRB- EGFR -RRB- tyrosine kinase .
20592628	0	tyrosine	206,214	epidermal_growth_factor_receptor	173,205	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Korean ethnicity as compared with white ethnicity is an independent favorable prognostic factor for overall_survival in non-small_cell_lung_cancer before and after the oral epidermal_growth_factor_receptor tyrosine kinase inhibitor era .
20672704	0	tyrosine	49,57	epidermal_growth_factor_receptor	16,48	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|Application Application|nmod|END_ENTITY	-LSB- Application of epidermal_growth_factor_receptor tyrosine kinase inhibitor as the first-line therapy in patients with advanced non-small_cell_lung_cancer -RSB- .
20679350	0	tyrosine	99,107	epidermal_growth_factor_receptor	66,98	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY END_ENTITY|dobj|inhibitors	Impact of serum hepatocyte_growth_factor on treatment response to epidermal_growth_factor_receptor tyrosine kinase inhibitors in patients with non-small_cell_lung_adenocarcinoma .
20735208	0	tyrosine	226,234	epidermal_growth_factor_receptor	193,225	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Rational approach to the synthesis , evaluation , and -LRB- 68 -RRB- ga labeling of a novel 4-anilinoquinoline epidermal_growth_factor_receptor inhibitor as a new imaging agent that selectively targets the epidermal_growth_factor_receptor tyrosine kinase .
20735208	0	tyrosine	226,234	epidermal_growth_factor_receptor	98,130	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY targets|dobj|kinase agent|acl:relcl|targets inhibitor|nmod|agent inhibitor|compound|END_ENTITY	Rational approach to the synthesis , evaluation , and -LRB- 68 -RRB- ga labeling of a novel 4-anilinoquinoline epidermal_growth_factor_receptor inhibitor as a new imaging agent that selectively targets the epidermal_growth_factor_receptor tyrosine kinase .
2083199	0	tyrosine	104,112	epidermal_growth_factor_receptor	48,80	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|Generation Generation|nmod|domain domain|nmod|END_ENTITY	Generation of recombinant cytoplasmic domain of epidermal_growth_factor_receptor with intrinsic protein tyrosine kinase activity .
20837451	0	tyrosine	118,126	epidermal_growth_factor_receptor	85,117	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Supersensitive mutation : two case reports of non-small-cell_lung_cancer treated with epidermal_growth_factor_receptor tyrosine kinase inhibitors .
20948254	0	tyrosine	52,60	epidermal_growth_factor_receptor	19,51	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|Re-treatment Re-treatment|nmod|END_ENTITY	-LSB- Re-treatment with epidermal_growth_factor_receptor tyrosine kinase inhibitor -LRB- EGFR-TKI -RRB- for lung_adenocarcinoma -RSB- .
20975380	0	tyrosine	120,128	epidermal_growth_factor_receptor	87,119	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	therapy|compound|START_ENTITY therapy|compound|END_ENTITY	Cetuximab monotherapy in patients with advanced non-small_cell_lung_cancer after prior epidermal_growth_factor_receptor tyrosine kinase inhibitor therapy .
21037017	0	tyrosine	64,72	epidermal_growth_factor_receptor	31,63	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitor|compound|START_ENTITY inhibitor|compound|END_ENTITY	Slug confers resistance to the epidermal_growth_factor_receptor tyrosine kinase inhibitor .
21107284	0	tyrosine	68,76	epidermal_growth_factor_receptor	35,67	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|value value|nmod|END_ENTITY	Prognostic and predictive value of epidermal_growth_factor_receptor tyrosine kinase domain mutation status and gene copy number for adjuvant chemotherapy in non-small_cell_lung_cancer .
21258250	0	tyrosine	149,157	epidermal_growth_factor_receptor	116,148	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Phosphoinositide-3-kinase catalytic alpha and KRAS mutations are important predictors of resistance to therapy with epidermal_growth_factor_receptor tyrosine kinase inhibitors in patients with advanced non-small_cell_lung_cancer .
21345607	0	tyrosine	54,62	epidermal_growth_factor_receptor	21,53	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Prospective study of epidermal_growth_factor_receptor tyrosine kinase inhibitors concurrent with individualized radiotherapy for patients with locally advanced or metastatic non-small-cell_lung_cancer .
21411993	0	tyrosine	191,199	epidermal_growth_factor_receptor	158,190	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|mutations mutations|nmod|factor factor|acl:relcl|treated treated|nmod|END_ENTITY	Epidermal_growth_factor_receptor mutations as a prognostic factor in Korean patients with advanced lung_adenocarcinoma who had not been treated with received epidermal_growth_factor_receptor tyrosine kinase inhibitors .
21428885	0	tyrosine	61,69	epidermal_growth_factor_receptor	28,60	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY END_ENTITY|dobj|inhibitors	Mechanisms of resistance to epidermal_growth_factor_receptor tyrosine kinase inhibitors in patients with advanced non-small-cell lung_cancer : clinical and molecular considerations .
21531810	0	tyrosine	17,25	epidermal_growth_factor_receptor	58,90	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinase|amod|START_ENTITY Effectiveness|nmod|kinase inhibitors|nsubj|Effectiveness inhibitors|nmod|mutations mutations|compound|END_ENTITY	Effectiveness of tyrosine kinase inhibitors on `` uncommon '' epidermal_growth_factor_receptor mutations of unknown clinical significance in non-small_cell_lung_cancer .
21623279	0	tyrosine	121,129	epidermal_growth_factor_receptor	88,120	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Phase II trial of dasatinib for patients with acquired resistance to treatment with the epidermal_growth_factor_receptor tyrosine kinase inhibitors erlotinib or gefitinib .
21626329	0	tyrosine	112,120	epidermal_growth_factor_receptor	31,63	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	treatment|amod|START_ENTITY outcome|nmod|treatment signal|nmod|outcome signal|nsubj|influence influence|nmod|END_ENTITY	The influence of intracellular epidermal_growth_factor_receptor -LRB- EGFR -RRB- signal activation on the outcome of EGFR tyrosine kinase inhibitor treatment for pulmonary_adenocarcinoma .
2166944	0	tyrosine	109,117	epidermal_growth_factor_receptor	27,59	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	activity|compound|START_ENTITY desensitization|nmod|activity desensitization|amod|END_ENTITY	Signal transduction by the epidermal_growth_factor_receptor after functional desensitization of the receptor tyrosine protein kinase activity .
2169740	0	tyrosine	68,76	epidermal_growth_factor_receptor	35,67	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Antibody-induced activation of the epidermal_growth_factor_receptor tyrosine kinase requires the presence of detergent .
21712475	0	tyrosine	95,103	epidermal_growth_factor_receptor	62,94	tyrosine	epidermal growth factor receptor	CHEBI:18186	13649(Tax:10090)	Chemical	Gene	inhibitor-resistance|amod|START_ENTITY inhibitor-resistance|amod|END_ENTITY	Liposomal delivery of MicroRNA-7-expressing plasmid overcomes epidermal_growth_factor_receptor tyrosine kinase inhibitor-resistance in lung_cancer cells .
21775534	0	tyrosine	85,93	epidermal_growth_factor_receptor	52,84	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY END_ENTITY|dobj|inhibitors	New strategies in overcoming acquired resistance to epidermal_growth_factor_receptor tyrosine kinase inhibitors in lung_cancer .
21777761	0	tyrosine	59,67	epidermal_growth_factor_receptor	19,51	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|Inhibitors Inhibitors|nmod|END_ENTITY	-LSB- Inhibitors of the epidermal_growth_factor_receptor -LRB- EGFR -RRB- tyrosine kinase : similarity and differences -RSB- .
21799026	0	tyrosine	127,135	epidermal_growth_factor_receptor	94,126	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|significance significance|nmod|thyroid_transcription_factor-1 thyroid_transcription_factor-1|nmod|lung_adenocarcinoma lung_adenocarcinoma|nmod|END_ENTITY	Clinical significance of thyroid_transcription_factor-1 in advanced lung_adenocarcinoma under epidermal_growth_factor_receptor tyrosine kinase inhibitor treatment .
21920622	0	tyrosine	59,67	epidermal_growth_factor_receptor	26,58	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|pregnancy pregnancy|nmod|END_ENTITY	Successful pregnancy with epidermal_growth_factor_receptor tyrosine kinase inhibitor treatment of metastatic_lung_adenocarcinoma presenting with respiratory_failure .
21921847	0	tyrosine	83,91	epidermal_growth_factor_receptor	50,82	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|system system|acl|monitoring monitoring|nmod|END_ENTITY	A noninvasive system for monitoring resistance to epidermal_growth_factor_receptor tyrosine kinase inhibitors with plasma DNA .
21964526	0	tyrosine	103,111	epidermal_growth_factor_receptor	70,102	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	treatment|amod|START_ENTITY treatment|compound|END_ENTITY	Serum heparan sulfate concentration is correlated with the failure of epidermal_growth_factor_receptor tyrosine kinase inhibitor treatment in patients with lung_adenocarcinoma .
21964534	0	tyrosine	140,148	epidermal_growth_factor_receptor	107,139	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|Changes Changes|nmod|profile profile|nmod|course course|nmod|treatment treatment|nmod|patients patients|nmod|END_ENTITY	Changes in plasma mass-spectral profile in course of treatment of non-small_cell_lung_cancer patients with epidermal_growth_factor_receptor tyrosine kinase inhibitors .
22026926	0	tyrosine	144,152	epidermal_growth_factor_receptor	10,42	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	domain|amod|START_ENTITY mutations|nmod|domain harbors|dobj|mutations harbors|nsubj|gene gene|compound|END_ENTITY	The human epidermal_growth_factor_receptor -LRB- EGFR -RRB- gene in European patients with advanced colorectal_cancer harbors infrequent mutations in its tyrosine kinase domain .
22154113	0	tyrosine	99,107	epidermal_growth_factor_receptor	66,98	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|csubj|Overcoming Overcoming|nmod|END_ENTITY	Overcoming molecular mechanisms of resistance to first-generation epidermal_growth_factor_receptor tyrosine kinase inhibitors .
22263036	0	tyrosine	45,53	epidermal_growth_factor_receptor	12,44	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	The role of epidermal_growth_factor_receptor tyrosine kinase inhibitors in the treatment of advanced stage non-small_cell_lung_cancer .
22336239	0	tyrosine	82,90	epidermal_growth_factor_receptor	47,79	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|progress progress|nmod|mechanisms mechanisms|nmod|END_ENTITY	-LSB- Research progress on resistance mechanisms of epidermal_growth_factor_receptor tyrosine kinase inhibitors in non-small_cell_lung_cancer -RSB- .
22370318	0	tyrosine	140,148	epidermal_growth_factor_receptor	107,139	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitor|compound|START_ENTITY inhibitor|compound|END_ENTITY	Vandetanib Versus placebo in patients with advanced non-small-cell_lung_cancer after prior therapy with an epidermal_growth_factor_receptor tyrosine kinase inhibitor : a randomized , double-blind phase III trial -LRB- ZEPHYR -RRB- .
22389426	0	tyrosine	58,66	epidermal_growth_factor_receptor	90,122	tyrosine	epidermal growth factor receptor	D014443	1956	Chemical	Gene	START_ENTITY|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Pituitary_adenylate_cyclase-activating_polypeptide causes tyrosine phosphorylation of the epidermal_growth_factor_receptor in lung_cancer cells .
22393153	0	tyrosine	47,55	epidermal_growth_factor_receptor	14,46	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Inhibition of epidermal_growth_factor_receptor tyrosine kinase ameliorates collagen-induced arthritis .
22426987	0	tyrosine	136,144	epidermal_growth_factor_receptor	43,75	tyrosine	epidermal growth factor receptor	D014443	1956	Chemical	Gene	sensitive|xcomp|START_ENTITY make|xcomp|sensitive mutations|acl:relcl|make tyrosine|dobj|mutations tyrosine|nsubj|Patients Patients|nmod|END_ENTITY	Patients with peritoneal_mesothelioma lack epidermal_growth_factor_receptor tyrosine kinase mutations that would make them sensitive to tyrosine kinase inhibitors .
22426987	0	tyrosine	76,84	epidermal_growth_factor_receptor	43,75	tyrosine	epidermal growth factor receptor	D014443	1956	Chemical	Gene	START_ENTITY|nsubj|Patients Patients|nmod|END_ENTITY	Patients with peritoneal_mesothelioma lack epidermal_growth_factor_receptor tyrosine kinase mutations that would make them sensitive to tyrosine kinase inhibitors .
22436374	0	tyrosine	130,138	epidermal_growth_factor_receptor	14,46	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY combining|nmod|inhibitors effect|acl|combining effect|dep|Targeting Targeting|dobj|END_ENTITY	Targeting the epidermal_growth_factor_receptor in non-small cell lung_cancer cells : the effect of combining RNA interference with tyrosine kinase inhibitors or cetuximab .
22446631	0	tyrosine	62,70	epidermal_growth_factor_receptor	29,61	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitor|compound|START_ENTITY inhibitor|compound|END_ENTITY	Effects of icotinib , a novel epidermal_growth_factor_receptor tyrosine kinase inhibitor , in EGFR-mutated non-small cell lung_cancer .
22571344	0	tyrosine	68,76	epidermal_growth_factor_receptor	35,67	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|Primary Primary|nmod|END_ENTITY	Primary and acquired resistance to epidermal_growth_factor_receptor tyrosine kinase inhibitors in non-small_cell_lung_cancer : an update .
22591401	0	tyrosine	122,130	epidermal_growth_factor_receptor	55,87	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	1045|amod|START_ENTITY hypo-phosphorylation|nmod|1045 caused|nmod|hypo-phosphorylation caused|nsubj|degradation degradation|acl|followed followed|nmod|enhanced enhanced|nmod|END_ENTITY	Impaired degradation followed by enhanced recycling of epidermal_growth_factor_receptor caused by hypo-phosphorylation of tyrosine 1045 in RBE cells .
22665120	0	tyrosine	50,58	epidermal_growth_factor_receptor	17,49	tyrosine	epidermal growth factor receptor	CHEBI:18186	13649(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	A novel role for epidermal_growth_factor_receptor tyrosine kinase and its downstream endoplasmic reticulum stress in cardiac_damage and microvascular_dysfunction_in_type_1_diabetes_mellitus .
22677429	0	tyrosine	45,53	epidermal_growth_factor_receptor	12,44	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|Efficacy Efficacy|nmod|END_ENTITY	Efficacy of epidermal_growth_factor_receptor tyrosine kinase inhibitors for brain metastasis in non-small_cell_lung_cancer patients harboring either exon 19 or 21 mutation .
22736441	0	tyrosine	34,42	epidermal_growth_factor_receptor	92,124	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|advcl|activating activating|dobj|mutation mutation|compound|END_ENTITY	Acquired resistance mechanisms to tyrosine kinase inhibitors in lung_cancer with activating epidermal_growth_factor_receptor mutation -- diversity , ductility , and destiny .
22788954	0	tyrosine	87,95	epidermal_growth_factor_receptor	54,86	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	resistance|amod|START_ENTITY END_ENTITY|dobj|resistance	Fibroblast-secreted hepatocyte_growth_factor mediates epidermal_growth_factor_receptor tyrosine kinase inhibitor resistance in triple-negative_breast_cancers through paracrine activation of Met .
22883988	0	tyrosine	70,78	epidermal_growth_factor_receptor	37,69	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|Correlation Correlation|nmod|efficacy efficacy|nmod|END_ENTITY	-LSB- Correlation between the efficacy of epidermal_growth_factor_receptor tyrosine kinase inhibitors and EGFR mutations in advanced squamous_cell_lung_cancer -RSB- .
23022519	0	tyrosine	40,48	epidermal_growth_factor_receptor	7,39	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Should epidermal_growth_factor_receptor tyrosine kinase inhibitors be considered ideal drugs for the treatment of selected advanced non-small_cell_lung_cancer patients ?
23153706	0	tyrosine	122,130	epidermal_growth_factor_receptor	10,42	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	epidermal_growth_factor_receptor|acl:relcl|START_ENTITY epidermal_growth_factor_receptor|dep|Targeting Targeting|dobj|END_ENTITY	Targeting epidermal_growth_factor_receptor / human epidermal_growth_factor_receptor 2 signalling pathway by a dual receptor tyrosine kinase inhibitor afatinib for radiosensitisation in murine bladder_carcinoma .
23162612	0	tyrosine	91,99	epidermal_growth_factor_receptor	58,90	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Molecular mechanisms of lung-specific toxicity induced by epidermal_growth_factor_receptor tyrosine kinase inhibitors .
23255886	0	tyrosine	41,49	epidermal_growth_factor_receptor	8,40	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of epidermal_growth_factor_receptor tyrosine kinase inhibitors in the treatment of esophageal_carcinoma and the suggested mechanisms of action .
23313110	0	tyrosine	132,140	epidermal_growth_factor_receptor	99,131	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|G12C G12C|nmod|types types|nmod|prediction prediction|nmod|efficacy efficacy|nmod|END_ENTITY	The dominant role of G12C over other KRAS mutation types in the negative prediction of efficacy of epidermal_growth_factor_receptor tyrosine kinase inhibitors in non-small_cell_lung_cancer .
23371912	0	tyrosine	11,19	epidermal_growth_factor_receptor	83,115	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|dobj|network network|acl|composed composed|nmod|oncogene oncogene|dep|END_ENTITY	A receptor tyrosine kinase network composed of fibroblast growth factor receptors , epidermal_growth_factor_receptor , v-erb-b2 erythroblastic_leukemia viral oncogene homolog 2 , and hepatocyte growth factor receptor drives growth and survival of head and neck squamous_carcinoma cell lines .
23559152	0	tyrosine	62,70	epidermal_growth_factor_receptor	22,54	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|resistance resistance|nmod|END_ENTITY	Primary resistance to epidermal_growth_factor_receptor -LRB- EGFR -RRB- tyrosine kinase inhibitors -LRB- TKIs -RRB- in patients with non-small-cell_lung_cancer harboring TKI-sensitive EGFR mutations : an exploratory study .
23582742	0	tyrosine	95,103	epidermal_growth_factor_receptor	62,94	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY END_ENTITY|dobj|inhibitors	A novel serum protein signature associated with resistance to epidermal_growth_factor_receptor tyrosine kinase inhibitors in head and neck_squamous_cell_carcinoma .
23700486	0	tyrosine	100,108	epidermal_growth_factor_receptor	10,42	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|csubj|Profiling Profiling|dobj|heteromerization heteromerization|compound|END_ENTITY	Profiling epidermal_growth_factor_receptor and heregulin receptor 3 heteromerization using receptor tyrosine kinase heteromer investigation technology .
23721103	0	tyrosine	136,144	epidermal_growth_factor_receptor	103,135	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitor|amod|START_ENTITY END_ENTITY|dobj|inhibitor	Detection of epidermal_growth_factor_receptor T790M mutation in plasma DNA from patients refractory to epidermal_growth_factor_receptor tyrosine kinase inhibitor .
23721103	0	tyrosine	136,144	epidermal_growth_factor_receptor	13,45	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitor|amod|START_ENTITY epidermal_growth_factor_receptor|dobj|inhibitor refractory|xcomp|epidermal_growth_factor_receptor refractory|nsubj|Detection Detection|nmod|mutation mutation|compound|END_ENTITY	Detection of epidermal_growth_factor_receptor T790M mutation in plasma DNA from patients refractory to epidermal_growth_factor_receptor tyrosine kinase inhibitor .
23749888	0	tyrosine	48,56	epidermal_growth_factor_receptor	15,47	tyrosine	epidermal growth factor receptor	D014443	1956	Chemical	Gene	inhibitor|amod|START_ENTITY END_ENTITY|dobj|inhibitor	Sensitivity to epidermal_growth_factor_receptor tyrosine kinase inhibitor requires E-cadherin in esophageal_cancer and malignant_pleural_mesothelioma .
23768755	0	tyrosine	33,41	epidermal_growth_factor_receptor	120,152	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY Epidermal_growth_factor_receptor|dobj|inhibitors Epidermal_growth_factor_receptor|dep|focus focus|nmod|testing testing|compound|END_ENTITY	Epidermal_growth_factor_receptor tyrosine kinase inhibitors as initial therapy for non-small_cell_lung_cancer : focus on epidermal_growth_factor_receptor mutation testing and mutation-positive patients .
23822636	0	tyrosine	53,61	epidermal_growth_factor_receptor	96,128	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|dobj|phosphorylation phosphorylation|nmod|conformation conformation|compound|END_ENTITY	Inverse correlation between Thr-669 and constitutive tyrosine phosphorylation in the asymmetric epidermal_growth_factor_receptor dimer conformation .
23853482	0	tyrosine	150,158	epidermal_growth_factor_receptor	117,149	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitor|compound|START_ENTITY inhibitor|compound|END_ENTITY	Transglutaminase_2 expression predicts progression free survival in non-small_cell_lung_cancer patients treated with epidermal_growth_factor_receptor tyrosine kinase inhibitor .
23873621	0	tyrosine	48,56	epidermal_growth_factor_receptor	15,47	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|Sensitivity Sensitivity|nmod|END_ENTITY	Sensitivity to epidermal_growth_factor_receptor tyrosine kinase inhibitors in males , smokers , and non-adenocarcinoma_lung_cancer in patients with EGFR mutations .
23874880	0	tyrosine	60,68	epidermal_growth_factor_receptor	27,59	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	resistance|amod|START_ENTITY resistance|compound|END_ENTITY	Targeting mTOR to overcome epidermal_growth_factor_receptor tyrosine kinase inhibitor resistance in non-small_cell_lung_cancer cells .
23916913	0	tyrosine	56,64	epidermal_growth_factor_receptor	23,55	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitor|amod|START_ENTITY END_ENTITY|dobj|inhibitor	Notch-1 contributes to epidermal_growth_factor_receptor tyrosine kinase inhibitor acquired resistance in non-small cell lung_cancer in vitro and in vivo .
24055492	0	tyrosine	49,57	epidermal_growth_factor_receptor	9,41	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitor|amod|START_ENTITY END_ENTITY|dep|inhibitor	Combined epidermal_growth_factor_receptor -LRB- EGFR -RRB- - tyrosine kinase inhibitor and chemotherapy in non-small-cell_lung_cancer : chemo-refractoriness of cells harboring sensitizing-EGFR_mutations in the presence of gefitinib .
24086072	0	tyrosine	109,117	epidermal_growth_factor_receptor	57,89	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	therapy|amod|START_ENTITY findings|nmod|therapy Advanced_lung_adenocarcinoma|dep|findings Advanced_lung_adenocarcinoma|acl|harboring harboring|dobj|mutation mutation|nmod|END_ENTITY	Advanced_lung_adenocarcinoma harboring a mutation of the epidermal_growth_factor_receptor : CT findings after tyrosine kinase inhibitor therapy .
24138718	0	tyrosine	154,162	epidermal_growth_factor_receptor	66,98	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	dependence|acl|START_ENTITY dependence|nmod|lung_cancer lung_cancer|nmod|END_ENTITY	Signaling pathways modulating dependence of lung_cancer on mutant epidermal_growth_factor_receptor and mechanisms of intrinsic and acquired resistance to tyrosine kinase inhibitors .
24170435	0	tyrosine	108,116	epidermal_growth_factor_receptor	75,107	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|treatment treatment|nmod|models models|nmod|END_ENTITY	Combination treatment of human pancreatic_cancer xenograft models with the epidermal_growth_factor_receptor tyrosine kinase inhibitor erlotinib and oncolytic_herpes_simplex_virus_HF10 .
2418024	1	tyrosine	75,83	epidermal_growth_factor_receptor	107,139	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	phosphorylation|amod|START_ENTITY effects|nmod|phosphorylation effects|nmod|END_ENTITY	Specific effects of GM3 on tyrosine phosphorylation of the epidermal_growth_factor_receptor .
24332915	0	tyrosine	134,142	epidermal_growth_factor_receptor	73,105	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY receiving|dobj|inhibitors carrying|advcl|receiving carrying|dobj|mutation mutation|compound|END_ENTITY	Predictors of outcome for patients with lung_adenocarcinoma carrying the epidermal_growth_factor_receptor mutation receiving 1st-line tyrosine kinase inhibitors : Sensitivity and meta-regression analysis of randomized trials .
24342626	0	tyrosine	104,112	epidermal_growth_factor_receptor	71,103	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|significance significance|nmod|heterogeneity heterogeneity|acl|retreatment retreatment|nmod|END_ENTITY	Clinical significance of heterogeneity in response to retreatment with epidermal_growth_factor_receptor tyrosine kinase inhibitors in patients with lung_cancer acquiring secondary resistance to the drug .
24348666	0	tyrosine	69,77	epidermal_growth_factor_receptor	36,68	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Molecular basis of drug resistance : epidermal_growth_factor_receptor tyrosine kinase inhibitors and anaplastic_lymphoma kinase inhibitors .
24401995	0	tyrosine	136,144	epidermal_growth_factor_receptor	103,135	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Different treatment orders achieved similar clinical results : a retrospective study for retreatment of epidermal_growth_factor_receptor tyrosine kinase inhibitors in 120 patients with non-small-cell_lung_cancer .
24453959	0	tyrosine	80,88	epidermal_growth_factor_receptor	39,71	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|simulation simulation|nmod|protein protein|compound|END_ENTITY	Coarse-grained molecular simulation of epidermal_growth_factor_receptor protein tyrosine kinase multi-site self-phosphorylation .
2454110	0	tyrosine	114,122	epidermal_growth_factor_receptor	20,52	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	activity|amod|START_ENTITY acquisition|nmod|activity Biosynthesis|dep|acquisition Biosynthesis|nmod|END_ENTITY	Biosynthesis of the epidermal_growth_factor_receptor : post-translational glycosylation-independent acquisition of tyrosine kinase autophosphorylation activity .
24629638	0	tyrosine	83,91	epidermal_growth_factor_receptor	43,75	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY Impact|dep|inhibitors Impact|nmod|smoking smoking|nmod|response response|nmod|END_ENTITY	Impact of cigarette smoking on response to epidermal_growth_factor_receptor -LRB- EGFR -RRB- - tyrosine kinase inhibitors in lung_adenocarcinoma with activating EGFR mutations .
24636263	0	tyrosine	86,94	epidermal_growth_factor_receptor	53,85	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY END_ENTITY|dobj|inhibitors	Acquired resistance of non-small_cell_lung_cancer to epidermal_growth_factor_receptor tyrosine kinase inhibitors .
24715074	0	tyrosine	33,41	epidermal_growth_factor_receptor	139,171	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY vs|nsubj|inhibitors vs|dobj|chemotherapy chemotherapy|nmod|END_ENTITY	Epidermal_growth_factor_receptor tyrosine kinase inhibitors vs conventional chemotherapy in non-small_cell_lung_cancer harboring wild-type epidermal_growth_factor_receptor : a meta-analysis .
24837299	0	tyrosine	63,71	epidermal_growth_factor_receptor	92,124	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	S-222611|appos|START_ENTITY activity|nmod|S-222611 kinase|nsubj|activity kinase|dobj|inhibitor inhibitor|nmod|epidermal_growth_factor_receptor_2 epidermal_growth_factor_receptor_2|compound|END_ENTITY	Preclinical antitumor activity of S-222611 , an oral reversible tyrosine kinase inhibitor of epidermal_growth_factor_receptor and human epidermal_growth_factor_receptor_2 .
24840891	0	tyrosine	103,111	epidermal_growth_factor_receptor	70,102	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitors|amod|START_ENTITY END_ENTITY|dobj|inhibitors	Combined gefitinib and pemetrexed overcome the acquired resistance to epidermal_growth_factor_receptor tyrosine kinase inhibitors in non-small_cell_lung_cancer .
25027951	0	tyrosine	38,46	epidermal_growth_factor_receptor	5,37	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Oral epidermal_growth_factor_receptor tyrosine kinase inhibitors for the treatment of non-small_cell_lung_cancer : comparative pharmacokinetics and drug-drug interactions .
25074884	0	tyrosine	83,91	epidermal_growth_factor_receptor	50,82	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Traditional Chinese medicinal herbs combined with epidermal_growth_factor_receptor tyrosine kinase inhibitor for advanced non-small_cell_lung_cancer : a systematic review and meta-analysis .
25103305	0	tyrosine	47,55	epidermal_growth_factor_receptor	14,46	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|Monitoring Monitoring|nmod|END_ENTITY	Monitoring of epidermal_growth_factor_receptor tyrosine kinase inhibitor-sensitizing and resistance mutations in the plasma DNA of patients with advanced non-small_cell_lung_cancer during treatment with erlotinib .
25199820	0	tyrosine	136,144	epidermal_growth_factor_receptor	87,119	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	gefitinib|amod|START_ENTITY harboring|nmod|gefitinib harboring|dobj|mutation mutation|compound|END_ENTITY	Melatonin sensitizes H1975 non-small-cell_lung_cancer cells harboring a T790M-targeted epidermal_growth_factor_receptor mutation to the tyrosine kinase inhibitor gefitinib .
25489260	0	tyrosine	67,75	epidermal_growth_factor_receptor	34,66	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Management of diarrhea induced by epidermal_growth_factor_receptor tyrosine kinase inhibitors .
25521095	0	tyrosine	56,64	epidermal_growth_factor_receptor	23,55	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|generation generation|nmod|END_ENTITY	The next generation of epidermal_growth_factor_receptor tyrosine kinase inhibitors in the treatment of lung_cancer .
2560399	0	tyrosine	92,100	epidermal_growth_factor_receptor	59,91	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Recombinant human m llerian inhibiting substance inhibits epidermal_growth_factor_receptor tyrosine kinase .
25842092	0	tyrosine	150,158	epidermal_growth_factor_receptor	82,114	tyrosine	epidermal growth factor receptor	D014443	1956	Chemical	Gene	inhibitors|compound|START_ENTITY role|nmod|inhibitors Treatment|dep|role Treatment|nmod|mutations mutations|amod|END_ENTITY	Treatment of brain metastases in non-small_cell_lung_cancer -LRB- NSCLC -RRB- patients with epidermal_growth_factor_receptor -LRB- EGFR -RRB- mutations : the role of EGFR tyrosine kinase inhibitors .
25865396	0	tyrosine	66,74	epidermal_growth_factor_receptor	33,65	tyrosine	epidermal growth factor receptor	D014443	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Diabetic_cardiomyopathy : Role of epidermal_growth_factor_receptor tyrosine kinase .
25865396	0	tyrosine	66,74	epidermal_growth_factor_receptor	33,65	tyrosine	epidermal growth factor receptor	D014443	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Diabetic_cardiomyopathy : Role of epidermal_growth_factor_receptor tyrosine kinase .
26014133	0	tyrosine	131,139	epidermal_growth_factor_receptor	50,82	tyrosine	epidermal growth factor receptor	D014443	1956	Chemical	Gene	inhibitors|compound|START_ENTITY non-small_cell_lung_cancer|nmod|inhibitors non-small_cell_lung_cancer|compound|END_ENTITY	Radiotherapy for asymptomatic brain_metastasis in epidermal_growth_factor_receptor mutant non-small_cell_lung_cancer without prior tyrosine kinase inhibitors treatment : a retrospective clinical study .
26015938	0	tyrosine	104,112	epidermal_growth_factor_receptor	71,103	tyrosine	epidermal growth factor receptor	D014443	1956	Chemical	Gene	START_ENTITY|nsubj|strategies strategies|nmod|resistance resistance|nmod|END_ENTITY	The latest therapeutic strategies after resistance to first generation epidermal_growth_factor_receptor tyrosine kinase inhibitors -LRB- EGFR TKIs -RRB- in patients with non-small_cell_lung_cancer -LRB- NSCLC -RRB- .
26036758	0	tyrosine	83,91	epidermal_growth_factor_receptor	50,82	tyrosine	epidermal growth factor receptor	D014443	1956	Chemical	Gene	resistance|amod|START_ENTITY resistance|compound|END_ENTITY	Posttranslational modifications of FOXO1 regulate epidermal_growth_factor_receptor tyrosine kinase inhibitor resistance for non-small_cell_lung_cancer cells .
26168678	0	tyrosine	81,89	epidermal_growth_factor_receptor	48,80	tyrosine	epidermal growth factor receptor	D014443	1956	Chemical	Gene	START_ENTITY|nsubj|concomitant concomitant|nmod|END_ENTITY	-LSB- Radiotherapy concomitant with first-generation epidermal_growth_factor_receptor tyrosine kinase inhibitors in the treatment of brain metastases from non_small_cell_lung_cancer : a meta-analysis -RSB- .
26169499	0	tyrosine	111,119	epidermal_growth_factor_receptor	78,110	tyrosine	epidermal growth factor receptor	D014443	1956	Chemical	Gene	therapy|amod|START_ENTITY END_ENTITY|dobj|therapy	Cytotoxic chemotherapy may overcome the development of acquired resistance to epidermal_growth_factor_receptor tyrosine kinase inhibitors -LRB- EGFR-TKIs -RRB- therapy .
26266101	0	tyrosine	53,61	epidermal_growth_factor_receptor	20,52	tyrosine	epidermal growth factor receptor	D014443	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Is there a role for epidermal_growth_factor_receptor tyrosine kinase inhibitors in epidermal_growth_factor_receptor wild-type non-small_cell_lung_cancer ?
26266101	0	tyrosine	53,61	epidermal_growth_factor_receptor	83,115	tyrosine	epidermal growth factor receptor	D014443	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|non-small_cell_lung_cancer non-small_cell_lung_cancer|amod|END_ENTITY	Is there a role for epidermal_growth_factor_receptor tyrosine kinase inhibitors in epidermal_growth_factor_receptor wild-type non-small_cell_lung_cancer ?
26269114	0	tyrosine	175,183	epidermal_growth_factor_receptor	17,49	tyrosine	epidermal growth factor receptor	D014443	1956	Chemical	Gene	inhibitors|compound|START_ENTITY treated|nmod|inhibitors treated|nsubj|Polymorphisms Polymorphisms|nmod|END_ENTITY	Polymorphisms in epidermal_growth_factor_receptor -LRB- EGFR -RRB- and AKT1 as possible predictors of clinical outcome in advanced non-small-cell_lung_cancer patients treated with EGFR tyrosine kinase inhibitors .
26315300	0	tyrosine	107,115	epidermal_growth_factor_receptor	74,106	tyrosine	epidermal growth factor receptor	D014443	1956	Chemical	Gene	START_ENTITY|nsubj|Amelioration Amelioration|nmod|arthritis arthritis|nmod|injection injection|nmod|END_ENTITY	Amelioration of experimental arthritis by intra-articular injection of an epidermal_growth_factor_receptor tyrosine kinase inhibitor .
26490356	0	tyrosine	155,163	epidermal_growth_factor_receptor	87,119	tyrosine	epidermal growth factor receptor	D014443	1956	Chemical	Gene	treatment|amod|START_ENTITY END_ENTITY|nmod|treatment	Comparison of clinical outcomes of patients with non-small-cell_lung_cancer harbouring epidermal_growth_factor_receptor exon 19 or exon 21 mutations after tyrosine kinase inhibitors treatment : a meta-analysis .
2661557	0	tyrosine	35,43	epidermal_growth_factor_receptor	65,97	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|dobj|domain domain|nmod|END_ENTITY	Activation of the purified protein tyrosine kinase domain of the epidermal_growth_factor_receptor .
26629426	0	tyrosine	73,81	epidermal_growth_factor_receptor	33,65	tyrosine	epidermal growth factor receptor	D014443	1956	Chemical	Gene	START_ENTITY|nsubj|Management Management|nmod|hyperglycemia hyperglycemia|nmod|END_ENTITY	Management of hyperglycemia from epidermal_growth_factor_receptor -LRB- EGFR -RRB- tyrosine kinase inhibitors -LRB- TKIs -RRB- targeting T790M-mediated resistance .
26639762	0	tyrosine	117,125	epidermal_growth_factor_receptor	84,116	tyrosine	epidermal growth factor receptor	D014443	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	4-Aminoindazolyl-dihydrofuro -LSB- 3,4-d -RSB- pyrimidines as non-covalent inhibitors of mutant epidermal_growth_factor_receptor tyrosine kinase .
26676152	0	tyrosine	136,144	epidermal_growth_factor_receptor	103,135	tyrosine	epidermal growth factor receptor	D014443	1956	Chemical	Gene	inhibition|amod|START_ENTITY END_ENTITY|dobj|inhibition	Crosstalk with cancer-associated fibroblasts induces resistance of non-small cell lung_cancer cells to epidermal_growth_factor_receptor tyrosine kinase inhibition .
26678713	0	tyrosine	124,132	epidermal_growth_factor_receptor	91,123	tyrosine	epidermal growth factor receptor	D014443	1956	Chemical	Gene	treatment|amod|START_ENTITY treatment|compound|END_ENTITY	Dynamics of circulating tumor DNA represented by the activating and resistant mutations in epidermal_growth_factor_receptor tyrosine kinase inhibitor treatment .
26767046	0	tyrosine	132,140	epidermal_growth_factor_receptor	99,131	tyrosine	epidermal growth factor receptor	D014443	1956	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Tumor MET expression profile predicts the outcome of non-small_cell_lung_cancer patients receiving epidermal_growth_factor_receptor tyrosine kinase inhibitors .
26854449	0	tyrosine	151,159	epidermal_growth_factor_receptor	116,148	tyrosine	epidermal growth factor receptor	D014443	1956	Chemical	Gene	kinase|amod|START_ENTITY END_ENTITY|amod|kinase	Essential oil of Cinnamon exerts anti-cancer activity against head_and_neck_squamous_cell_carcinoma via attenuating epidermal_growth_factor_receptor - tyrosine kinase .
26883272	0	tyrosine	109,117	epidermal_growth_factor_receptor	76,108	tyrosine	epidermal growth factor receptor	D014443	1956	Chemical	Gene	inhibitor|amod|START_ENTITY END_ENTITY|dobj|inhibitor	Targeting adenine_nucleotide translocase-2 -LRB- ANT2 -RRB- to overcome resistance to epidermal_growth_factor_receptor tyrosine kinase inhibitor in non-small_cell_lung_cancer .
26898616	0	tyrosine	49,57	epidermal_growth_factor_receptor	79,111	tyrosine	epidermal growth factor receptor	D014443	1956	Chemical	Gene	START_ENTITY|dobj|inhibitors inhibitors|nmod|END_ENTITY	Next-generation epidermal_growth_factor_receptor tyrosine kinase inhibitors in epidermal_growth_factor_receptor - mutant non-small_cell_lung_cancer .
26904214	0	tyrosine	133,141	epidermal_growth_factor_receptor	100,132	tyrosine	epidermal growth factor receptor	D014443	1956	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Factors that predict progression-free survival in Chinese_lung_adenocarcinoma patients treated with epidermal_growth_factor_receptor tyrosine kinase inhibitors .
26911477	0	tyrosine	43,51	epidermal_growth_factor_receptor	97,129	tyrosine	epidermal growth factor receptor	D014443	1956	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|nmod|treatment treatment|nmod|mutation mutation|compound|END_ENTITY	Flipped script for gefitinib : A reapproved tyrosine kinase inhibitor for first-line treatment of epidermal_growth_factor_receptor mutation positive metastatic nonsmall_cell_lung_cancer .
2784435	0	tyrosine	68,76	epidermal_growth_factor_receptor	35,67	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Protein kinase C inhibition of the epidermal_growth_factor_receptor tyrosine protein kinase activity is independent of the oligomeric state of the receptor .
2786142	0	tyrosine	43,51	epidermal_growth_factor_receptor	89,121	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinases|compound|START_ENTITY heterogeneity|nmod|kinases heterogeneity|dep|terminus terminus|nmod|proliferation proliferation|compound|END_ENTITY	Functional heterogeneity of proto-oncogene tyrosine kinases : the C terminus of the human epidermal_growth_factor_receptor facilitates cell proliferation .
2839511	1	tyrosine	88,96	epidermal_growth_factor_receptor	120,152	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	phosphorylation|amod|START_ENTITY effects|nmod|phosphorylation effects|nmod|END_ENTITY	Specific effects of GM3 and lyso-GM3 in tyrosine phosphorylation of the epidermal_growth_factor_receptor .
3013845	0	tyrosine	23,31	epidermal_growth_factor_receptor	55,87	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|dobj|activity activity|nmod|END_ENTITY	Suppression of protein tyrosine kinase activity of the epidermal_growth_factor_receptor by epidermal growth factor .
3024008	0	tyrosine	49,57	epidermal_growth_factor_receptor	77,109	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	A chimaeric receptor allows insulin to stimulate tyrosine kinase activity of epidermal_growth_factor_receptor .
3346210	0	tyrosine	109,117	epidermal_growth_factor_receptor	14,46	tyrosine	epidermal growth factor receptor	CHEBI:18186	100774580	Chemical	Gene	self-phosphorylation|amod|START_ENTITY site|nmod|self-phosphorylation Alteration|nmod|site Alteration|nmod|activity activity|compound|END_ENTITY	Alteration of epidermal_growth_factor_receptor activity by mutation of its primary carboxyl-terminal site of tyrosine self-phosphorylation .
3367910	0	tyrosine	31,39	epidermal_growth_factor_receptor	59,91	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Kinetics and regulation of the tyrosine phosphorylation of epidermal_growth_factor_receptor in intact A431 cells .
3501826	0	tyrosine	65,73	epidermal_growth_factor_receptor	9,41	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY END_ENTITY|nmod|kinase	A mutant epidermal_growth_factor_receptor with defective protein tyrosine kinase is unable to stimulate proto-oncogene expression and DNA synthesis .
6294827	0	tyrosine	30,38	epidermal_growth_factor_receptor	76,108	tyrosine	epidermal growth factor receptor	CHEBI:18186	24329(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Dimethyl_sulfoxide stimulates tyrosine residue phosphorylation of rat liver epidermal_growth_factor_receptor .
7488034	0	tyrosine	57,65	epidermal_growth_factor_receptor	21,53	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	845|amod|START_ENTITY END_ENTITY|nmod|845	c-Src phosphorylates epidermal_growth_factor_receptor on tyrosine 845 .
7498649	0	tyrosine	74,82	epidermal_growth_factor_receptor	41,73	tyrosine	epidermal growth factor receptor	CHEBI:18186	24329(Tax:10116)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Shc is a substrate of the rat intestinal epidermal_growth_factor_receptor tyrosine kinase .
7508718	0	tyrosine	32,40	epidermal_growth_factor_receptor	110,142	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|dobj|phosphorylation phosphorylation|nmod|proteins proteins|acl|associated associated|nmod|translocation translocation|nmod|END_ENTITY	Epidermal_growth_factor induced tyrosine phosphorylation of nuclear proteins associated with translocation of epidermal_growth_factor_receptor into the nucleus .
7510340	2	tyrosine	194,202	epidermal_growth_factor_receptor	139,171	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Synthesis of 2,2 ' - dithiobis -LRB- 1H-indole-3-alkanamides -RRB- and investigation of their inhibitory activity against epidermal_growth_factor_receptor and pp60v-src protein tyrosine kinases .
7562908	2	tyrosine	150,158	epidermal_growth_factor_receptor	182,214	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	7-Amino-4 - -LRB- phenylamino -RRB- - _ and_7-amino-4 - -LSB- -LRB- phenylmethyl -RRB- amino -RSB- pyrido -LSB- 4,3-d -RSB- pyrimidines : a new class of inhibitors of the tyrosine kinase activity of the epidermal_growth_factor_receptor .
7608194	0	tyrosine	68,76	epidermal_growth_factor_receptor	31,63	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	phosphorylation|amod|START_ENTITY END_ENTITY|nmod|phosphorylation	Structural requirements of the epidermal_growth_factor_receptor for tyrosine phosphorylation of eps8 and eps15 , substrates lacking Src SH2 homology domains .
7608909	0	tyrosine	116,124	epidermal_growth_factor_receptor	75,107	tyrosine	epidermal growth factor receptor	CHEBI:18186	13649(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	-LSB- -LRB- Alkylamino -RRB- methyl -RSB- acrylophenones : potent and selective inhibitors of the epidermal_growth_factor_receptor protein tyrosine kinase .
7634398	0	tyrosine	76,84	epidermal_growth_factor_receptor	43,75	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|activation activation|nmod|END_ENTITY	Inhibition of ligand-induced activation of epidermal_growth_factor_receptor tyrosine phosphorylation by curcumin .
7658435	2	tyrosine	206,214	epidermal_growth_factor_receptor	236,268	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Synthesis and structure-activity relationships for 4 - -LSB- -LRB- phenylmethyl -RRB- amino -RSB- - _ and_4 - -LRB- phenylamino -RRB- quinazolines as potent adenosine_5 ' - triphosphate binding site inhibitors of the tyrosine kinase domain of the epidermal_growth_factor_receptor .
7673163	0	tyrosine	34,42	epidermal_growth_factor_receptor	65,97	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	Association|nmod|START_ENTITY phosphatases|nsubj|Association phosphatases|nmod|END_ENTITY	Association of SH2 domain protein tyrosine phosphatases with the epidermal_growth_factor_receptor in human tumor cells .
7679104	0	tyrosine	21,29	epidermal_growth_factor_receptor	53,85	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Amphiregulin induces tyrosine phosphorylation of the epidermal_growth_factor_receptor and p185erbB2 .
7679612	0	tyrosine	69,77	epidermal_growth_factor_receptor	36,68	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	phosphorylation|amod|START_ENTITY END_ENTITY|dobj|phosphorylation	Exogenous phosphotyrosine modulates epidermal_growth_factor_receptor tyrosine phosphorylation .
7683493	0	tyrosine	82,90	epidermal_growth_factor_receptor	49,81	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|Antibodies Antibodies|nmod|sites sites|nmod|END_ENTITY	Antibodies against highly conserved sites in the epidermal_growth_factor_receptor tyrosine kinase domain as probes for structure and function .
7720669	0	tyrosine	129,137	epidermal_growth_factor_receptor	14,46	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|Modulation Modulation|nmod|interaction interaction|compound|END_ENTITY	Modulation of epidermal_growth_factor_receptor interaction with the detergent-insoluble cytoskeleton and its effects on receptor tyrosine kinase activity .
7770063	0	tyrosine	62,70	epidermal_growth_factor_receptor	29,61	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|response response|nmod|END_ENTITY	Differential response of the epidermal_growth_factor_receptor tyrosine kinase activity to several plant and mammalian lectins .
7805884	0	tyrosine	46,54	epidermal_growth_factor_receptor	74,106	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Hydrogen_peroxide preferentially enhances the tyrosine phosphorylation of epidermal_growth_factor_receptor .
7901224	0	tyrosine	91,99	epidermal_growth_factor_receptor	38,70	tyrosine	epidermal growth factor receptor	CHEBI:18186	13649(Tax:10090)	Chemical	Gene	activities|compound|START_ENTITY activities|compound|END_ENTITY	Differential heat stress stability of epidermal_growth_factor_receptor and erbB-2 receptor tyrosine kinase activities .
7991458	0	tyrosine	77,85	epidermal_growth_factor_receptor	44,76	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|Design Design|nmod|inhibitor inhibitor|nmod|END_ENTITY	Design of a potent peptide inhibitor of the epidermal_growth_factor_receptor tyrosine kinase utilizing sequences based on the natural phosphorylation sites of phospholipase_C-gamma_1 .
8183246	0	tyrosine	45,53	epidermal_growth_factor_receptor	77,109	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Kinetics of inhibition by tyrphostins of the tyrosine kinase activity of the epidermal_growth_factor_receptor and analysis by a new computer program .
8224241	0	tyrosine	51,59	epidermal_growth_factor_receptor	18,50	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of the epidermal_growth_factor_receptor tyrosine kinase activity by leflunomide .
8243311	0	tyrosine	66,74	epidermal_growth_factor_receptor	33,65	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|Evidence Evidence|nmod|potentiation potentiation|nmod|END_ENTITY	Evidence for the potentiation of epidermal_growth_factor_receptor tyrosine kinase activity by association with the detergent-insoluble cellular cytoskeleton : analysis of intact and carboxy-terminally truncated receptors .
8253771	0	tyrosine	20,28	epidermal_growth_factor_receptor	124,156	tyrosine	epidermal growth factor receptor	CHEBI:18186	13649(Tax:10090)	Chemical	Gene	epidermal_growth_factor_receptor|amod|START_ENTITY Expression|nmod|epidermal_growth_factor_receptor amplifies|nsubj|Expression amplifies|xcomp|signaling signaling|nmod|END_ENTITY	Expression of human tyrosine kinase-negative epidermal_growth_factor_receptor amplifies signaling through endogenous murine epidermal_growth_factor_receptor .
8262933	0	tyrosine	45,53	epidermal_growth_factor_receptor	89,121	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|acl:relcl|separable separable|nmod|END_ENTITY	Epidermal_growth_factor stimulates a protein tyrosine kinase which is separable from the epidermal_growth_factor_receptor .
8276804	0	tyrosine	18,26	epidermal_growth_factor_receptor	48,80	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	The intracellular tyrosine kinase domain of the epidermal_growth_factor_receptor undergoes a conformational change upon autophosphorylation .
8355247	2	tyrosine	115,123	epidermal_growth_factor_receptor	82,114	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Structure-activity relationships for inhibition of epidermal_growth_factor_receptor tyrosine kinase activity by 2,3-dihydro-2-thioxo-1H-indole-3-alkanoic _ acids and 2,2 ' - dithiobis -LRB- 1H-indole-3-alkanoic_acids -RRB- .
8389462	0	tyrosine	33,41	epidermal_growth_factor_receptor	96,128	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	activity|amod|START_ENTITY specify|dobj|activity features|acl:relcl|specify deduced|nsubj|features deduced|nmod|modeling modeling|nmod|END_ENTITY	Structural features that specify tyrosine kinase activity deduced from homology modeling of the epidermal_growth_factor_receptor .
8390452	0	tyrosine	104,112	epidermal_growth_factor_receptor	47,79	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	phosphatase|amod|START_ENTITY activation|nmod|phosphatase regulates|nmod|activation regulates|dobj|END_ENTITY	Mitogen-activated protein kinase regulates the epidermal_growth_factor_receptor through activation of a tyrosine phosphatase .
8396132	0	tyrosine	128,136	epidermal_growth_factor_receptor	38,70	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	motif|amod|START_ENTITY analogous|nmod|motif codes|amod|analogous mediated|nmod|codes mediated|nsubjpass|internalization internalization|nmod|END_ENTITY	Ligand-induced internalization of the epidermal_growth_factor_receptor is mediated by multiple endocytic codes analogous to the tyrosine motif found in constitutively internalized receptors .
8497428	0	tyrosine	117,125	epidermal_growth_factor_receptor	84,116	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	autophosphorylation|compound|START_ENTITY autophosphorylation|compound|END_ENTITY	Genistein and biochanin_A inhibit the growth of human prostate_cancer cells but not epidermal_growth_factor_receptor tyrosine autophosphorylation .
8608124	0	tyrosine	36,44	epidermal_growth_factor_receptor	59,91	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|dobj|kinase kinase|nmod|END_ENTITY	Thermal inactivation of the protein tyrosine kinase of the epidermal_growth_factor_receptor .
8621384	0	tyrosine	90,98	epidermal_growth_factor_receptor	18,50	tyrosine	epidermal growth factor receptor	CHEBI:18186	13649(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|Activation Activation|nmod|transduction transduction|compound|END_ENTITY	Activation of the epidermal_growth_factor_receptor signal transduction pathway stimulates tyrosine phosphorylation of protein_kinase_C_delta .
8627606	2	tyrosine	133,141	epidermal_growth_factor_receptor	165,197	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	function|amod|START_ENTITY function|nmod|END_ENTITY	Isomeric 4 - -LSB- -LRB- 3-bromophenyl -RRB- amino -RSB- pyrido -LSB- d -RSB- - pyrimidines are potent ATP binding site inhibitors of the tyrosine kinase function of the epidermal_growth_factor_receptor .
8632415	2	tyrosine	127,135	epidermal_growth_factor_receptor	159,191	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Synthesis and evaluation of fused tricyclic quinazoline analogues as ATP site inhibitors of the tyrosine kinase activity of the epidermal_growth_factor_receptor .
8649342	0	tyrosine	138,146	epidermal_growth_factor_receptor	105,137	tyrosine	epidermal growth factor receptor	CHEBI:18186	101838749	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Regulation of 13 -LRB- S -RRB- - hydroxyoctadecadienoic_acid biosynthesis in Syrian_hamster embryo fibroblasts by the epidermal_growth_factor_receptor tyrosine kinase .
8702638	0	tyrosine	80,88	epidermal_growth_factor_receptor	3,35	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation tyrosine|ccomp|induces END_ENTITY|parataxis|tyrosine	An epidermal_growth_factor_receptor / Jak2 tyrosine kinase domain chimera induces tyrosine phosphorylation of Stat5 and transduces a growth signal in hematopoietic cells .
8714355	0	tyrosine	5,13	epidermal_growth_factor_receptor	50,82	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	-LSB- The tyrosine kinase activity of the internalized epidermal_growth_factor_receptor in A-431 cells -RSB- .
8761379	0	tyrosine	170,178	epidermal_growth_factor_receptor	137,169	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Differential effect of polyunsaturated_fatty_acids on cell proliferation during human epithelial in vitro carcinogenesis : involvement of epidermal_growth_factor_receptor tyrosine kinase .
8765213	0	tyrosine	117,125	epidermal_growth_factor_receptor	84,116	tyrosine	epidermal growth factor receptor	CHEBI:18186	24329(Tax:10116)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Inhibition of gastric mucosal regeneration by tyrphostin : evaluation of the role of epidermal_growth_factor_receptor tyrosine kinase .
9006938	0	tyrosine	151,159	epidermal_growth_factor_receptor	46,78	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	phosphorylation|compound|START_ENTITY levels|nmod|phosphorylation mediated|nmod|levels mediated|nsubjpass|activity activity|nmod|common common|compound|END_ENTITY	The enhanced tumorigenic activity of a mutant epidermal_growth_factor_receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling .
9010029	0	tyrosine	173,181	epidermal_growth_factor_receptor	75,107	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	phosphatase|compound|START_ENTITY involvement|nmod|phosphatase inhibition|dep|involvement inhibition|nmod|cells cells|nmod|antibodies antibodies|nmod|END_ENTITY	Growth inhibition of human lung_adenocarcinoma cells by antibodies against epidermal_growth_factor_receptor and by ganglioside GM3 : involvement of receptor-directed protein tyrosine phosphatase -LRB- s -RRB- .
9027015	0	tyrosine	174,182	epidermal_growth_factor_receptor	110,142	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	-RSB-|amod|START_ENTITY containing|nmod|-RSB- containing|dobj|END_ENTITY	-LSB- The association of a protein regulator of intracellular Rab7 membrane transport with endosomes containing an epidermal_growth_factor_receptor with activated and inactivated tyrosine kinase -RSB- .
9045422	0	tyrosine	91,99	epidermal_growth_factor_receptor	123,155	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- The dependence of the type of endocytosis of EGF receptor complexes on the basal level of tyrosine kinase activity in the epidermal_growth_factor_receptor -RSB- .
9045597	0	tyrosine	110,118	epidermal_growth_factor_receptor	77,109	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Immobilized glucose-6-phosphate_dehydrogenase as a substrate for solubilized epidermal_growth_factor_receptor tyrosine kinase .
9060993	0	tyrosine	14,22	epidermal_growth_factor_receptor	140,172	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	activity|amod|START_ENTITY Inhibition|nmod|activity decreases|nsubj|Inhibition decreases|nmod|independent independent|nmod|END_ENTITY	Inhibition of tyrosine kinase activity decreases expression of surfactant_protein_A in a human lung_adenocarcinoma cell line independent of epidermal_growth_factor_receptor .
9162524	0	tyrosine	47,55	epidermal_growth_factor_receptor	14,46	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Activation of epidermal_growth_factor_receptor tyrosine phosphorylation by tumor necrosis factor correlates with loss of cytotoxic activity .
9174106	0	tyrosine	49,57	epidermal_growth_factor_receptor	16,48	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Requirement for epidermal_growth_factor_receptor tyrosine kinase and for 12-lipoxygenase activity in the expression of 12-lipoxygenase in human epidermoid_carcinoma cells .
9291107	0	tyrosine	70,78	epidermal_growth_factor_receptor	37,69	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Nitric_oxide reversibly inhibits the epidermal_growth_factor_receptor tyrosine kinase .
9309250	0	tyrosine	65,73	epidermal_growth_factor_receptor	32,64	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Genistein analogues : effects on epidermal_growth_factor_receptor tyrosine kinase and on stress-activated pathways .
9355745	0	tyrosine	54,62	epidermal_growth_factor_receptor	85,117	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	phosphorylated|advmod|START_ENTITY phosphorylated|nmod|END_ENTITY	Protein_tyrosine_phosphatase_1B interacts with and is tyrosine phosphorylated by the epidermal_growth_factor_receptor .
9397172	2	tyrosine	170,178	epidermal_growth_factor_receptor	202,234	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Structure-activity relationships for soluble 7-substituted_4 - -LSB- -LRB- 3-bromophenyl -RRB- amino -RSB- pyrido -LSB- 4,3-d -RSB- pyrimidines designed as inhibitors of the tyrosine kinase activity of the epidermal_growth_factor_receptor .
9419975	0	tyrosine	76,84	epidermal_growth_factor_receptor	104,136	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Epiregulin binds to epidermal_growth_factor_receptor and ErbB-4 and induces tyrosine phosphorylation of epidermal_growth_factor_receptor , ErbB-2 , ErbB-3 and ErbB-4 .
9603960	0	tyrosine	8,16	epidermal_growth_factor_receptor	36,68	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Role of tyrosine kinase activity of epidermal_growth_factor_receptor in the lysophosphatidic_acid-stimulated mitogen-activated protein kinase pathway .
9642287	0	tyrosine	44,52	epidermal_growth_factor_receptor	60,92	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	221|amod|START_ENTITY protein|nmod|221 adaptor|dobj|protein adaptor|nmod|END_ENTITY	Phosphorylation of CrkII adaptor protein at tyrosine 221 by epidermal_growth_factor_receptor .
9692551	0	tyrosine	59,67	epidermal_growth_factor_receptor	26,58	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Tandem duplication of the epidermal_growth_factor_receptor tyrosine kinase and calcium internalization domains in A-172 glioma cells .
9751783	0	tyrosine	105,113	epidermal_growth_factor_receptor	43,75	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	inhibitor|amod|START_ENTITY class|nmod|inhibitor Specific|nmod|class Specific|appos|inactivation inactivation|nmod|END_ENTITY	Specific , irreversible inactivation of the epidermal_growth_factor_receptor and erbB2 , by a new class of tyrosine kinase inhibitor .
9788758	0	tyrosine	37,45	epidermal_growth_factor_receptor	4,36	tyrosine	epidermal growth factor receptor	CHEBI:18186	24329(Tax:10116)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The epidermal_growth_factor_receptor tyrosine kinase phosphorylates connexin32 .
9811719	0	tyrosine	103,111	epidermal_growth_factor_receptor	62,94	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Adeno-associated virus_type_2-mediated gene transfer : role of epidermal_growth_factor_receptor protein tyrosine kinase in transgene expression .
9815602	0	tyrosine	12,20	epidermal_growth_factor_receptor	48,80	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinase|amod|START_ENTITY inhibitor|amod|kinase PD153035|appos|inhibitor prevents|nsubj|PD153035 prevents|dobj|activation activation|compound|END_ENTITY	PD153035 , a tyrosine kinase inhibitor , prevents epidermal_growth_factor_receptor activation and inhibits growth of cancer cells in a receptor number-dependent manner .
9815668	0	tyrosine	131,139	epidermal_growth_factor_receptor	90,122	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|Therapy Therapy|nmod|carcinoma_of_the_bladder carcinoma_of_the_bladder|nmod|administration administration|nmod|protein protein|compound|END_ENTITY	Therapy of human transitional cell carcinoma_of_the_bladder by oral administration of the epidermal_growth_factor_receptor protein tyrosine kinase inhibitor 4,5-dianilinophthalimide .
9829728	0	tyrosine	134,142	epidermal_growth_factor_receptor	101,133	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Alpha-cyano-beta-hydroxy-beta-methyl-N - -LSB- 4 - -LRB- trifluoromethoxy -RRB- phenyl -RSB- _ propenamide : an inhibitor of the epidermal_growth_factor_receptor tyrosine kinase with potent cytotoxic activity against breast_cancer cells .
9849459	0	tyrosine	145,153	epidermal_growth_factor_receptor	102,134	tyrosine	epidermal growth factor receptor	CHEBI:18186	1956	Chemical	Gene	kinases|amod|START_ENTITY family|nmod|kinases family|compound|END_ENTITY	Inhibition of growth of primary human tumour cell cultures by a 4-anilinoquinazoline inhibitor of the epidermal_growth_factor_receptor family of tyrosine kinases .
9856979	0	tyrosine	21,29	epidermal_growth_factor_receptor	49,81	tyrosine	epidermal growth factor receptor	CHEBI:18186	100008806(Tax:9986)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|association association|compound|END_ENTITY	Arachidonate-induced tyrosine phosphorylation of epidermal_growth_factor_receptor and Shc-Grb2-Sos association .
9886803	0	tyrosine	175,183	epidermal_growth_factor_receptor	207,239	tyrosine	epidermal growth factor receptor	CHEBI:18186	24329(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Epidermal growth factor-induced heterologous desensitization of the luteinizing hormone/choriogonadotropin receptor in a cell-free membrane preparation is associated with the tyrosine phosphorylation of the epidermal_growth_factor_receptor .
20110044	0	tyrosine	119,127	epidermal_growth_factor_receptor-2	84,118	tyrosine	epidermal growth factor receptor-2	CHEBI:18186	2064	Chemical	Gene	kinases|compound|START_ENTITY kinases|amod|END_ENTITY	Lapatinib : a small-molecule inhibitor of epidermal_growth_factor_receptor and human epidermal_growth_factor_receptor-2 tyrosine kinases used in the treatment of breast_cancer .
22821179	0	tyrosine	103,111	epidermal_growth_factor_receptors	69,102	tyrosine	epidermal growth factor receptors	CHEBI:18186	1956	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Combined Erlotinib and Cetuximab overcome the acquired resistance to epidermal_growth_factor_receptors tyrosine kinase inhibitor in non-small-cell lung_cancer .
7608194	0	tyrosine	68,76	eps8	96,100	tyrosine	eps8	CHEBI:18186	2059	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Structural requirements of the epidermal_growth_factor_receptor for tyrosine phosphorylation of eps8 and eps15 , substrates lacking Src SH2 homology domains .
12392638	0	tyrosine	60,68	era	53,56	tyrosine	era	CHEBI:18186	26284	Chemical	Gene	kinase|amod|START_ENTITY END_ENTITY|nmod|kinase	Management of gastrointestinal_stromal_tumors in the era of tyrosine kinase inhibitors .
17080234	0	tyrosine	45,53	era	34,37	tyrosine	era	CHEBI:18186	26284	Chemical	Gene	inhibitors|amod|START_ENTITY GIST|nmod|inhibitors GIST|nmod|END_ENTITY	Outcome of metastatic GIST in the era before tyrosine kinase inhibitors .
17382018	0	tyrosine	121,129	era	114,117	tyrosine	era	CHEBI:18186	26284	Chemical	Gene	inhibitors|amod|START_ENTITY END_ENTITY|nmod|inhibitors	Allogeneic hematopoietic progenitor cell transplantation for the treatment of chronic_myelogenous_leukemia in the era of tyrosine kinase inhibitors : lessons learned to date .
18300759	0	tyrosine	66,74	era	59,62	tyrosine	era	CHEBI:18186	26284	Chemical	Gene	inhibitors|amod|START_ENTITY END_ENTITY|nmod|inhibitors	Who with chronic_myelogenous_leukemia to transplant in the era of tyrosine kinase inhibitors ?
18721758	0	tyrosine	121,129	era	114,117	tyrosine	era	CHEBI:18186	26284	Chemical	Gene	kinase|amod|START_ENTITY END_ENTITY|nmod|kinase	Allogeneic hematopoietic cell transplantation for adult Philadelphia-positive acute_lymphoblastic_leukemia in the era of tyrosine kinase inhibitors .
18765156	0	tyrosine	54,62	era	47,50	tyrosine	era	CHEBI:18186	26284	Chemical	Gene	inhibitors|amod|START_ENTITY END_ENTITY|nmod|inhibitors	Current status of debulking nephrectomy in the era of tyrosine kinase inhibitors .
19117213	0	tyrosine	80,88	era	73,76	tyrosine	era	CHEBI:18186	26284	Chemical	Gene	inhibitors|amod|START_ENTITY END_ENTITY|nmod|inhibitors	Management of the advanced phases of chronic_myelogenous_leukemia in the era of tyrosine kinase inhibitors .
19679008	0	tyrosine	32,40	era	58,61	tyrosine	era	CHEBI:18186	26284	Chemical	Gene	kinase|amod|START_ENTITY END_ENTITY|amod|kinase	Chronic_myeloid_leukemia in the tyrosine kinase inhibitor era : what is the best therapy ?
20017605	0	tyrosine	85,93	era	74,77	tyrosine	era	CHEBI:18186	26284	Chemical	Gene	inhibitors|amod|START_ENTITY END_ENTITY|nmod|inhibitors	State-of-the-art in the management of chronic_myelogenous_leukemia in the era of the tyrosine kinase inhibitors : evolutionary trends in diagnosis , monitoring and treatment .
20017608	0	tyrosine	54,62	era	47,50	tyrosine	era	CHEBI:18186	26284	Chemical	Gene	inhibitors|amod|START_ENTITY END_ENTITY|nmod|inhibitors	Hematopoietic stem cell transplantation in the era of tyrosine kinase inhibitors .
20968202	0	tyrosine	47,55	era	40,43	tyrosine	era	CHEBI:18186	26284	Chemical	Gene	inhibitors|amod|START_ENTITY END_ENTITY|nmod|inhibitors	Chronic_myeloid_leukemia therapy in the era of tyrosine kinase inhibitors -- the first molecular targeted treatment .
21365622	0	tyrosine	132,140	era	125,128	tyrosine	era	CHEBI:18186	26284	Chemical	Gene	inhibitors|amod|START_ENTITY END_ENTITY|nmod|inhibitors	Prognostic significance of immunophenotypic and karyotypic features of Philadelphia positive B-lymphoblastic_leukemia in the era of tyrosine kinase inhibitors .
21411987	0	tyrosine	108,116	era	101,104	tyrosine	era	CHEBI:18186	26284	Chemical	Gene	inhibitors|amod|START_ENTITY END_ENTITY|nmod|inhibitors	Challenges for allogeneic hematopoietic stem cell transplantation in chronic_myeloid_leukemia in the era of tyrosine kinase inhibitors .
23250623	0	tyrosine	82,90	era	75,78	tyrosine	era	CHEBI:18186	26284	Chemical	Gene	therapy|amod|START_ENTITY END_ENTITY|nmod|therapy	Outcome of allogeneic SCT in patients with chronic_myeloid_leukemia in the era of tyrosine kinase inhibitor therapy .
23265925	0	tyrosine	57,65	era	50,53	tyrosine	era	CHEBI:18186	26284	Chemical	Gene	inhibitors|amod|START_ENTITY END_ENTITY|nmod|inhibitors	Brain metastases from renal_cell_carcinoma in the era of tyrosine kinase inhibitors .
23684143	0	tyrosine	128,136	era	121,124	tyrosine	era	CHEBI:18186	26284	Chemical	Gene	inhibitors|amod|START_ENTITY END_ENTITY|nmod|inhibitors	Prognostic factors for outcomes of allogeneic stem_cell_transplantation in chronic_phase chronic_myeloid_leukemia in the era of tyrosine kinase inhibitors .
24382642	0	tyrosine	160,168	era	186,189	tyrosine	era	CHEBI:18186	26284	Chemical	Gene	kinase|compound|START_ENTITY imatinib|nmod|kinase END_ENTITY|amod|imatinib	Drug resistance and BCR-ABL kinase domain mutations in Philadelphia_chromosome-positive_acute_lymphoblastic_leukemia from the imatinib to the second-generation tyrosine kinase inhibitor era : The main changes are in the type of mutations , but not in the frequency of mutation involvement .
24900820	0	tyrosine	39,47	era	32,35	tyrosine	era	CHEBI:18186	26284	Chemical	Gene	kinase|amod|START_ENTITY END_ENTITY|nmod|kinase	A new challenging and promising era of tyrosine kinase inhibitors .
25085253	0	tyrosine	140,148	era	133,136	tyrosine	era	CHEBI:18186	26284	Chemical	Gene	inhibitors|amod|START_ENTITY END_ENTITY|nmod|inhibitors	Effect of graft sources on allogeneic hematopoietic stem cell transplantation outcome in adults with chronic_myeloid_leukemia in the era of tyrosine kinase inhibitors : a Japanese Society of Hematopoietic Cell Transplantation retrospective analysis .
25089599	0	tyrosine	117,125	era	110,113	tyrosine	era	CHEBI:18186	26284	Chemical	Gene	inhibitors|amod|START_ENTITY END_ENTITY|nmod|inhibitors	An update on allogeneic hematopoietic progenitor cell transplantation for myeloproliferative neoplasms in the era of tyrosine kinase inhibitors .
25238206	0	tyrosine	39,47	era	32,35	tyrosine	era	CHEBI:18186	26284	Chemical	Gene	inhibitors|amod|START_ENTITY END_ENTITY|nmod|inhibitors	Medullary thyroid_cancer in the era of tyrosine kinase inhibitors : to treat or not to treat -- and with which drug -- those are the questions .
25931274	0	tyrosine	115,123	era	108,111	tyrosine	era	D014443	26284	Chemical	Gene	inhibitors|amod|START_ENTITY END_ENTITY|nmod|inhibitors	Impact of trisomy 8 on treatment response and survival of patients with chronic_myelogenous_leukemia in the era of tyrosine kinase inhibitors .
25960187	0	tyrosine	111,119	era	104,107	tyrosine	era	D014443	26284	Chemical	Gene	inhibitors|amod|START_ENTITY END_ENTITY|nmod|inhibitors	Myeloid_sarcoma as the initial presentation of chronic myelogenous_leukemia , medullary chronic phase in era of tyrosine kinase inhibitors : A report of 11 cases .
26479889	0	tyrosine	94,102	era	87,90	tyrosine	era	D014443	26284	Chemical	Gene	inhibitors|amod|START_ENTITY END_ENTITY|nmod|inhibitors	Conditional survival in patients with chronic_myeloid_leukemia_in_chronic_phase in the era of tyrosine kinase inhibitors .
26837843	0	tyrosine	141,149	era	134,137	tyrosine	era	D014443	26284	Chemical	Gene	therapy|amod|START_ENTITY END_ENTITY|nmod|therapy	Differential impact of additional chromosomal abnormalities in myeloid vs lymphoid blast phase of chronic_myelogenous_leukemia in the era of tyrosine kinase inhibitor therapy .
26990676	0	tyrosine	116,124	era	109,112	tyrosine	era	D014443	26284	Chemical	Gene	inhibitors|amod|START_ENTITY Estimation|nmod|inhibitors Estimation|nmod|END_ENTITY	Estimation of the prevalence and direct medical costs of chronic_myeloid_leukemia in the I.R. of Iran in the era of tyrosine kinase inhibitors .
10339605	0	tyrosine	97,105	erbB	83,87	tyrosine	erbB	CHEBI:18186	1956	Chemical	Gene	kinases|amod|START_ENTITY kinases|compound|END_ENTITY	Induction of the Tat-binding_protein_1 gene accompanies the disabling of oncogenic erbB receptor tyrosine kinases .
11916237	0	tyrosine	34,42	erbB	14,18	tyrosine	erbB	CHEBI:18186	1956	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|receptor receptor|amod|END_ENTITY	Inhibition of erbB receptor -LRB- HER -RRB- tyrosine kinases as a strategy to abrogate antiestrogen resistance in human breast_cancer .
15572027	0	tyrosine	67,75	erbB	46,50	tyrosine	erbB	CHEBI:18186	1956	Chemical	Gene	kinases|amod|START_ENTITY kinases|amod|END_ENTITY	G1 cell cycle arrest due to the inhibition of erbB family receptor tyrosine kinases does not require the retinoblastoma protein .
19010087	0	tyrosine	134,142	erbB	120,124	tyrosine	erbB	CHEBI:18186	1956	Chemical	Gene	kinases|compound|START_ENTITY kinases|amod|END_ENTITY	A liquid chromatography mass spectrometry assay for determination of PD168393 , a specific and irreversible inhibitor of erbB membrane tyrosine kinases , in rat serum .
16367926	0	tyrosine	27,35	erbB-2	20,26	tyrosine	erbB-2	CHEBI:18186	2064	Chemical	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	SUCI02 inhibits the erbB-2 tyrosine kinase receptor signaling pathway and arrests the cell cycle in G1 phase in breast_cancer cells .
1672440	0	tyrosine	40,48	erbB-2	144,150	tyrosine	erbB-2	CHEBI:18186	13866(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY signaling|parataxis|phosphorylation mitogenic|acl|signaling correlate|nsubj|mitogenic correlate|nmod|potency potency|amod|END_ENTITY	The erbB-2 mitogenic signaling pathway : tyrosine phosphorylation of phospholipase C-gamma and GTPase-activating protein does not correlate with erbB-2 mitogenic potency .
1672440	0	tyrosine	40,48	erbB-2	4,10	tyrosine	erbB-2	CHEBI:18186	13866(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY signaling|parataxis|phosphorylation mitogenic|acl|signaling mitogenic|amod|END_ENTITY	The erbB-2 mitogenic signaling pathway : tyrosine phosphorylation of phospholipase C-gamma and GTPase-activating protein does not correlate with erbB-2 mitogenic potency .
18814184	0	tyrosine	4,12	erbB-2	35,41	tyrosine	erbB-2	CHEBI:18186	13866(Tax:10090)	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|dobj|HER2 HER2|dep|END_ENTITY	The tyrosine kinase receptor HER2 -LRB- erbB-2 -RRB- : from oncogenesis to adipogenesis .
19242112	0	tyrosine	23,31	erbB-2	16,22	tyrosine	erbB-2	CHEBI:18186	2064	Chemical	Gene	signal|compound|START_ENTITY signal|amod|END_ENTITY	ON-III inhibits erbB-2 tyrosine kinase receptor signal pathway and triggers apoptosis through induction of Bim in breast_cancer cells .
1983208	0	tyrosine	55,63	erbB-2	11,17	tyrosine	erbB-2	CHEBI:18186	13866(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|nsubj|product product|amod|END_ENTITY	The normal erbB-2 product is an atypical receptor-like tyrosine kinase with constitutive activity in the absence of ligand .
2188097	0	tyrosine	133,141	erbB-2	32,38	tyrosine	erbB-2	CHEBI:18186	13866(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|domains domains|nmod|effects effects|amod|END_ENTITY	The carboxy-terminal domains of erbB-2 and epidermal_growth_factor_receptor exert different regulatory effects on intrinsic receptor tyrosine kinase function and transforming activity .
2901952	0	tyrosine	45,53	erbB-2	77,83	tyrosine	erbB-2	CHEBI:18186	2064	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|protein protein|amod|END_ENTITY	Egf binding to its receptor triggers a rapid tyrosine phosphorylation of the erbB-2 protein in the mammary_tumor cell line SK-BR-3 .
9988227	1	tyrosine	150,158	erbB-2	360,366	tyrosine	erbB-4	CHEBI:18186	2066	Chemical	Gene	activity|amod|START_ENTITY possesses|dobj|activity protein|acl:relcl|possesses encodes|dobj|protein encodes|parataxis|stimulated stimulated|nmod|heregulins heregulins|acl:relcl|enables enables|dobj|receptor receptor|acl|form form|nmod|END_ENTITY	The erbB-4 gene encodes a detected receptor protein that possesses intrinsic tyrosine kinase activity and belongs to the family of the epidermal_growth_factor_receptor -LRB- EGFR -RRB- ; erbB-4 is stimulated by the heregulins and betacellulin , which enables this receptor to form heterodimers with erbB-2 , a prerequisite for erbB-2 activation .
8464905	0	tyrosine	58,66	erbB-3	51,57	tyrosine	erbB-3	CHEBI:18186	2065	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Demonstration of ligand-dependent signaling by the erbB-3 tyrosine kinase and its constitutive activation in human breast_tumor cells .
10318765	0	tyrosine	54,62	erbB2	39,44	tyrosine	erbB2	CHEBI:18186	2064	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Activation-dependent clustering of the erbB2 receptor tyrosine kinase detected by scanning near-field optical microscopy .
11751413	0	tyrosine	40,48	erbB2	101,106	tyrosine	erbB2	CHEBI:18186	2064	Chemical	Gene	START_ENTITY|ccomp|inhibits inhibits|dep|overexpressing overexpressing|nsubj|HER2/neu HER2/neu|appos|END_ENTITY	Epidermal_growth_factor_receptor -LRB- HER1 -RRB- tyrosine kinase inhibitor ZD1839 -LRB- Iressa -RRB- inhibits HER2/neu -LRB- erbB2 -RRB- - overexpressing breast_cancer cells in vitro and in vivo .
12238488	0	tyrosine	54,62	erbB2	34,39	tyrosine	erbB2	CHEBI:18186	2064	Chemical	Gene	relevance|acl|START_ENTITY destruction|dep|relevance destruction|nmod|END_ENTITY	Chaperone-mediated destruction of erbB2 : relevance to tyrosine kinase inhibitors .
12859950	0	tyrosine	48,56	erbB2	84,89	tyrosine	erbB2	CHEBI:18186	2064	Chemical	Gene	kinases|amod|START_ENTITY selectivity|nmod|kinases selectivity|dep|novel novel|dep|inhibitor inhibitor|amod|END_ENTITY	Achieving selectivity between highly homologous tyrosine kinases : a novel selective erbB2 inhibitor .
1378622	0	tyrosine	56,64	erythropoietin	19,33	tyrosine	erythropoietin	CHEBI:18186	13856(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Association Association|nmod|receptor receptor|compound|END_ENTITY	Association of the erythropoietin receptor with protein tyrosine kinase activity .
1656216	0	tyrosine	13,21	erythropoietin_receptor	45,68	tyrosine	erythropoietin receptor	CHEBI:18186	13857(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Induction of tyrosine phosphorylation by the erythropoietin_receptor correlates with mitogenesis .
21978374	0	tyrosine	78,86	estrogen_receptor-alpha	19,42	tyrosine	estrogen receptor-alpha	CHEBI:18186	2099	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Down-regulation of estrogen_receptor-alpha and rearranged_during_transfection tyrosine kinase is associated with withaferin a-induced apoptosis in MCF-7 breast_cancer cells .
17908813	0	tyrosine	58,66	ezrin	52,57	tyrosine	ezrin	D014443	7430	Chemical	Gene	START_ENTITY|nsubj|induction induction|nmod|END_ENTITY	Chlamydia_trachomatis species-specific induction of ezrin tyrosine phosphorylation functions in pathogen entry .
2406026	0	tyrosine	103,111	fasciclin_I	79,90	tyrosine	fasciclin I	CHEBI:18186	42025(Tax:7227)	Chemical	Gene	mutations|compound|START_ENTITY mutations|compound|END_ENTITY	Genetic analysis of a Drosophila neural cell adhesion molecule : interaction of fasciclin_I and Abelson tyrosine kinase mutations .
8373729	0	tyrosine	40,48	ferT	0,4	tyrosine	ferT	CHEBI:18186	14158(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY encodes|dobj|kinase encodes|nsubj|END_ENTITY	ferT encodes a meiosis-specific nuclear tyrosine kinase .
8977243	0	tyrosine	77,85	fetal_liver_phosphatase_1	32,57	tyrosine	fetal liver phosphatase 1	CHEBI:18186	19253(Tax:10090)	Chemical	Gene	phosphatase|compound|START_ENTITY END_ENTITY|appos|phosphatase	Cloning and characterization of fetal_liver_phosphatase_1 , a nuclear protein tyrosine phosphatase isolated from hematopoietic stem cells .
10656975	0	tyrosine	65,73	fibrinogen	42,52	tyrosine	fibrinogen	CHEBI:18186	2244	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	H -LRB- 2 -RRB- O -LRB- 2 -RRB- activity on platelet adhesion to fibrinogen and protein tyrosine phosphorylation .
7693700	0	tyrosine	80,88	fibroblast_growth_factor-1	50,76	tyrosine	fibroblast growth factor-1	CHEBI:18186	14164(Tax:10090)	Chemical	Gene	residues|amod|START_ENTITY END_ENTITY|nmod|residues	Murine cortactin is phosphorylated in response to fibroblast_growth_factor-1 on tyrosine residues late in the G1 phase of the BALB/c 3T3 cell cycle .
19955487	0	tyrosine	129,137	fibroblast_growth_factor_receptor-3	158,193	tyrosine	fibroblast growth factor receptor-3	CHEBI:18186	2261	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|nmod|END_ENTITY	1-tert-butyl-3 - -LSB- 6 - -LRB- 3,5-dimethoxy-phenyl -RRB- -2 - -LRB- 4-diethylamino-butylamino -RRB- - pyrido -LSB- 2,3-d -RSB- pyrimidin-7-yl -RSB- - urea -LRB- PD173074 -RRB- , a selective tyrosine kinase inhibitor of fibroblast_growth_factor_receptor-3 -LRB- FGFR3 -RRB- , inhibits cell proliferation of bladder_cancer carrying the FGFR3 gene mutation along with up-regulation of p27/Kip1 and G1/G0 arrest .
11459840	0	tyrosine	12,20	fibroblast_growth_factor_receptor_1	33,68	tyrosine	fibroblast growth factor receptor 1	CHEBI:18186	79114(Tax:10116)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	The role of tyrosine residues in fibroblast_growth_factor_receptor_1 signaling in PC12 cells .
7784079	0	tyrosine	33,41	fibroblast_growth_factor_receptor_1	52,87	tyrosine	fibroblast growth factor receptor 1	CHEBI:18186	14182(Tax:10090)	Chemical	Gene	activation|nmod|START_ENTITY kinase|nsubj|activation kinase|nmod|END_ENTITY	Ligand-independent activation of tyrosine kinase in fibroblast_growth_factor_receptor_1 by fusion with beta-galactosidase .
11294897	0	tyrosine	18,26	fibroblast_growth_factor_receptor_3	64,99	tyrosine	fibroblast growth factor receptor 3	CHEBI:18186	2261	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Identification of tyrosine residues in constitutively activated fibroblast_growth_factor_receptor_3 involved in mitogenesis , Stat activation , and phosphatidylinositol 3-kinase activation .
7670477	0	tyrosine	28,36	fibroblast_growth_factor_receptor_3	54,89	tyrosine	fibroblast growth factor receptor 3	CHEBI:18186	2261	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	A recurrent mutation in the tyrosine kinase domain of fibroblast_growth_factor_receptor_3 causes hypochondroplasia .
7919361	0	tyrosine	80,88	flk-2	59,64	tyrosine	flk-2	CHEBI:18186	14255(Tax:10090)	Chemical	Gene	kinase|amod|START_ENTITY receptor|amod|kinase Cellular|dep|receptor Cellular|nmod|role role|nmod|END_ENTITY	Cellular and molecular characterization of the role of the flk-2 / flt-3 receptor tyrosine kinase in hematopoietic stem cells .
8575794	0	tyrosine	105,113	flk-2	99,104	tyrosine	flk-2	CHEBI:18186	14255(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Isolation and characterization of a monoclonal antibody binding to the extracellular domain of the flk-2 tyrosine kinase receptor .
8919023	0	tyrosine	50,58	flt-1	44,49	tyrosine	flt-1	CHEBI:18186	2321	Chemical	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Characterization of the promoter region for flt-1 tyrosine kinase gene , a receptor for vascular endothelial growth factor .
7919361	0	tyrosine	80,88	flt-3	65,70	tyrosine	flt-3	CHEBI:18186	14255(Tax:10090)	Chemical	Gene	kinase|amod|START_ENTITY receptor|amod|kinase receptor|amod|END_ENTITY	Cellular and molecular characterization of the role of the flk-2 / flt-3 receptor tyrosine kinase in hematopoietic stem cells .
10208419	0	tyrosine	31,39	focal_adhesion_kinase	59,80	tyrosine	focal adhesion kinase	CHEBI:18186	5747	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Rho-dependent and - independent tyrosine phosphorylation of focal_adhesion_kinase , paxillin and p130Cas mediated by Ret kinase .
10409242	0	tyrosine	29,37	focal_adhesion_kinase	57,78	tyrosine	focal adhesion kinase	CHEBI:18186	506270(Tax:9913)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Hydrogen_peroxide stimulates tyrosine phosphorylation of focal_adhesion_kinase in vascular endothelial cells .
10633075	0	tyrosine	79,87	focal_adhesion_kinase	107,128	tyrosine	focal adhesion kinase	CHEBI:18186	14083(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Clustering of cell surface -LRB- beta -RRB- 1,4-galactosyltransferase I induces transient tyrosine phosphorylation of focal_adhesion_kinase and loss of stress fibers .
10878015	1	tyrosine	168,176	focal_adhesion_kinase	216,237	tyrosine	focal adhesion kinase	CHEBI:18186	25614(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Relationship to Shb tyrosine phosphorylation and elevated levels of focal_adhesion_kinase .
11120604	0	tyrosine	23,31	focal_adhesion_kinase	68,89	tyrosine	focal adhesion kinase	CHEBI:18186	14083(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Cell density regulates tyrosine phosphorylation and localization of focal_adhesion_kinase .
11399057	0	tyrosine	58,66	focal_adhesion_kinase	86,107	tyrosine	focal adhesion kinase	CHEBI:18186	14083(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Y-27632 , an inhibitor of Rho-associated kinases , prevents tyrosine phosphorylation of focal_adhesion_kinase and paxillin induced by bombesin : dissociation from tyrosine phosphorylation of p130 -LRB- CAS -RRB- .
12548551	0	tyrosine	51,59	focal_adhesion_kinase	16,37	tyrosine	focal adhesion kinase	CHEBI:18186	14083(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Dissociation of focal_adhesion_kinase and paxillin tyrosine phosphorylation induced by bombesin and lysophosphatidic_acid from epidermal_growth_factor_receptor transactivation in Swiss_3T3 cells .
14667936	0	tyrosine	6,14	focal_adhesion_kinase	34,55	tyrosine	focal adhesion kinase	CHEBI:18186	5747	Chemical	Gene	START_ENTITY|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Rapid tyrosine phosphorylation of focal_adhesion_kinase , paxillin , and p130Cas by gastrin in human colon_cancer cells .
15096502	0	tyrosine	123,131	focal_adhesion_kinase	66,87	tyrosine	focal adhesion kinase	CHEBI:18186	5747	Chemical	Gene	sites|compound|START_ENTITY sites|amod|END_ENTITY	Mechanical strain on osteoblasts activates autophosphorylation of focal_adhesion_kinase and proline-rich_tyrosine_kinase_2 tyrosine sites involved in ERK activation .
15537746	0	tyrosine	90,98	focal_adhesion_kinase	118,139	tyrosine	focal adhesion kinase	CHEBI:18186	14083(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Sodium_arsenite exposure alters cell migration , focal adhesion localization and decreases tyrosine phosphorylation of focal_adhesion_kinase in H9C2 myoblasts .
15694384	0	tyrosine	88,96	focal_adhesion_kinase	116,137	tyrosine	focal adhesion kinase	CHEBI:18186	14083(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Growth factors stimulate kidney proximal tubule cell migration independent of augmented tyrosine phosphorylation of focal_adhesion_kinase .
16253116	0	tyrosine	55,63	focal_adhesion_kinase	83,104	tyrosine	focal adhesion kinase	CHEBI:18186	14083(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Minimal features of paxillin that are required for the tyrosine phosphorylation of focal_adhesion_kinase .
16293639	0	tyrosine	83,91	focal_adhesion_kinase	115,136	tyrosine	focal adhesion kinase	CHEBI:18186	14083(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Activation of the lutropin/choriogonadotropin _ receptor in MA-10 cells leads to the tyrosine phosphorylation of the focal_adhesion_kinase by a pathway that involves Src family kinases .
18184462	0	tyrosine	22,30	focal_adhesion_kinase	50,71	tyrosine	focal adhesion kinase	CHEBI:18186	5747	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	-LSB- Effect of gastrin on tyrosine phosphorylation of focal_adhesion_kinase in human gastric_cancer cell line SGC7901 -RSB- .
18628478	0	tyrosine	5,13	focal_adhesion_kinase	35,56	tyrosine	focal adhesion kinase	CHEBI:18186	5747	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|nmod|END_ENTITY	Dual tyrosine kinase inhibitor for focal_adhesion_kinase and insulin-like_growth_factor-I_receptor exhibits anticancer effect in esophageal_adenocarcinoma in vitro and in vivo .
19339212	0	tyrosine	9,17	focal_adhesion_kinase	37,58	tyrosine	focal adhesion kinase	CHEBI:18186	14083(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Specific tyrosine phosphorylation of focal_adhesion_kinase mediated by Fer tyrosine kinase in suspended hepatocytes .
21544400	0	tyrosine	30,38	focal_adhesion_kinase	58,79	tyrosine	focal adhesion kinase	CHEBI:18186	5747	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Gamma_linolenic_acid inhibits tyrosine phosphorylation of focal_adhesion_kinase and paxillin and tumour cell matrix interaction .
21898124	0	tyrosine	68,76	focal_adhesion_kinase	96,117	tyrosine	focal adhesion kinase	D014443	5747	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Pituitary_adenylate_cyclase-activating_polypeptide causes increased tyrosine phosphorylation of focal_adhesion_kinase and paxillin .
21900245	0	tyrosine	40,48	focal_adhesion_kinase	68,89	tyrosine	focal adhesion kinase	CHEBI:18186	5747	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Paxillin enables attachment-independent tyrosine phosphorylation of focal_adhesion_kinase and transformation by RAS .
22487216	0	tyrosine	70,78	focal_adhesion_kinase	38,59	tyrosine	focal adhesion kinase	CHEBI:18186	5747	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Phosphotyrosine enrichment identifies focal_adhesion_kinase and other tyrosine kinases for targeting in canine hemangiosarcoma .
9553131	0	tyrosine	30,38	focal_adhesion_kinase	79,100	tyrosine	focal adhesion kinase	CHEBI:18186	14083(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Growth_hormone stimulates the tyrosine phosphorylation and association of p125 focal_adhesion_kinase -LRB- FAK -RRB- with JAK2 .
16841086	0	tyrosine	11,19	fyn	27,30	tyrosine	fyn	CHEBI:18186	14360(Tax:10090)	Chemical	Gene	kinase|amod|START_ENTITY phosphorylates|amod|kinase phosphorylates|compound|END_ENTITY	Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt , preventing its apoptotic cleavage and promoting cell survival .
7557381	0	tyrosine	4,12	fyn	0,3	tyrosine	fyn	CHEBI:18186	14360(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	fyn tyrosine kinase is involved in keratinocyte differentiation control .
8388744	0	tyrosine	12,20	fyn	29,32	tyrosine	fyn	CHEBI:18186	2534	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	The protein tyrosine kinase , fyn , in Alzheimer 's _ disease pathology .
8765711	0	tyrosine	48,56	fyn	44,47	tyrosine	fyn	CHEBI:18186	2534	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Solution studies of the SH2 domain from the fyn tyrosine kinase : secondary structure , backbone dynamics and protein association .
8904782	0	tyrosine	40,48	fyn	36,39	tyrosine	fyn	CHEBI:18186	14360(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Preservation Preservation|nmod|learning learning|nmod|END_ENTITY	Preservation of spatial learning in fyn tyrosine kinase knockout mice .
9345044	0	tyrosine	83,91	fyn	71,74	tyrosine	fyn	CHEBI:18186	2534	Chemical	Gene	START_ENTITY|nsubj|activity activity|nmod|protein protein|compound|END_ENTITY	Increased enzymatic activity of the T-cell antigen receptor-associated fyn protein tyrosine kinase in asymptomatic patients infected with the human_immunodeficiency_virus .
9374107	0	tyrosine	65,73	fyn	61,64	tyrosine	fyn	CHEBI:18186	2534	Chemical	Gene	kinase|amod|START_ENTITY END_ENTITY|dobj|kinase	Human airway epithelial cells stimulate T-lymphocyte lck and fyn tyrosine kinase .
11027663	0	tyrosine	20,28	gab1	48,52	tyrosine	gab1	CHEBI:18186	2549	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Flt3 ligand induces tyrosine phosphorylation of gab1 and gab2 and their association with shp-2 , grb2 , and PI3 kinase .
9334333	0	tyrosine	86,94	gap-1	57,62	tyrosine	gap-1	CHEBI:18186	180530(Tax:6239)	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Inhibition of Caenorhabditis_elegans vulval_induction by gap-1 and by let-23 receptor tyrosine kinase .
3107554	0	tyrosine	35,43	glucocorticoid_receptor	69,92	tyrosine	glucocorticoid receptor	CHEBI:18186	2908	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Epidermal_growth_factor stimulates tyrosine phosphorylation of human glucocorticoid_receptor in cultured cells .
3122660	0	tyrosine	33,41	glucose-6-phosphate_dehydrogenase	68,101	tyrosine	glucose-6-phosphate dehydrogenase	CHEBI:18186	855480(Tax:4932)	Chemical	Gene	START_ENTITY|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Epidermal growth factor receptor tyrosine kinase phosphorylation of glucose-6-phosphate_dehydrogenase in vitro .
9930729	0	tyrosine	105,113	glycogen_synthase_kinase-3beta	66,96	tyrosine	glycogen synthase kinase-3beta	CHEBI:18186	2932	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Insulin transiently increases tau phosphorylation : involvement of glycogen_synthase_kinase-3beta and Fyn tyrosine kinase .
1653651	4	tyrosine	594,602	gp145trkB	584,593	tyrosine	gp145trkC	CHEBI:18186	4916	Chemical	Gene	kinases|compound|START_ENTITY kinases|amod|END_ENTITY	The product of the trkC gene has been identified as a glycoprotein of 145,000 daltons , gp145trkC , which is equally related to the previously characterized gp140trk and gp145trkB tyrosine kinases .
4039619	0	tyrosine	77,85	gp180	57,62	tyrosine	gp180	CHEBI:18186	5788	Chemical	Gene	START_ENTITY|nsubj|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation of the postsynaptic density glycoprotein gp180 by endogenous tyrosine kinase .
7723626	0	tyrosine	76,84	growth_factor_receptor	53,75	tyrosine	growth factor receptor	CHEBI:18186	20187(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Isolation and expression analysis of tyro3 , a murine growth_factor_receptor tyrosine kinase preferentially expressed in adult brain .
2478547	0	tyrosine	100,108	growth_hormone	35,49	tyrosine	growth hormone	CHEBI:18186	2688	Chemical	Gene	receptors|nmod|START_ENTITY receptors|compound|END_ENTITY	Phosphorylation of highly purified growth_hormone receptors by a growth_hormone receptor-associated tyrosine kinase .
7535764	0	tyrosine	14,22	growth_hormone_receptor	45,68	tyrosine	growth hormone receptor	CHEBI:18186	2690	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	Intracellular tyrosine residues of the human growth_hormone_receptor are not required for the signaling of proliferation or Jak-STAT activation .
9121492	0	tyrosine	48,56	growth_hormone_receptor	18,41	tyrosine	growth hormone receptor	CHEBI:18186	14600(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification of growth_hormone_receptor -LRB- GHR -RRB- tyrosine residues required for GHR phosphorylation and JAK2 and STAT5 activation .
9070223	0	tyrosine	73,81	hPTP-J	100,106	tyrosine	hPTP-J	CHEBI:18186	10076	Chemical	Gene	START_ENTITY|dobj|gene gene|appos|END_ENTITY	Molecular cloning and characterization of a novel human receptor protein tyrosine phosphatase gene , hPTP-J : down-regulation of gene expression by PMA and calcium ionophore in Jurkat T_lymphoma cells .
8845750	0	tyrosine	55,63	hPTP1B	40,46	tyrosine	hPTP1B	CHEBI:18186	5770	Chemical	Gene	phosphatases|compound|START_ENTITY phosphatases|amod|END_ENTITY	Thermosensitive mutants of the MPTP and hPTP1B protein tyrosine phosphatases : isolation and structural analysis .
1764064	0	tyrosine	40,48	hck	36,39	tyrosine	hck	CHEBI:18186	25734(Tax:10116)	Chemical	Gene	kinase|amod|START_ENTITY END_ENTITY|dobj|kinase	Identification of rat cDNA encoding hck tyrosine kinase from megakaryocytes .
3141554	0	tyrosine	51,59	hck	73,76	tyrosine	hck	CHEBI:18186	3055	Chemical	Gene	START_ENTITY|dobj|gene gene|appos|END_ENTITY	Augmented expression of a myeloid-specific protein tyrosine kinase gene -LRB- hck -RRB- after macrophage activation .
8929559	0	tyrosine	44,52	hck	40,43	tyrosine	hck	CHEBI:18186	15162(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Expression of the activated -LRB- Y501-F501 -RRB- hck tyrosine kinase in 32Dcl3 myeloid cells prolongs survival in the absence of IL-3 and blocks granulocytic differentiation in response to G-CSF .
9400828	0	tyrosine	124,132	hck	120,123	tyrosine	hck	CHEBI:18186	15162(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Bacterial LPS and IFN-gamma trigger the tyrosine phosphorylation of vav in macrophages : evidence for involvement of the hck tyrosine kinase .
21767894	0	tyrosine	130,138	heat_shock_protein_90	33,54	tyrosine	heat shock protein 90	CHEBI:18186	3320	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|inhibitor inhibitor|amod|END_ENTITY	The anti-proliferative effect of heat_shock_protein_90 inhibitor , 17-DMAG , on non-small-cell_lung_cancers being resistant to EGFR tyrosine kinase inhibitor .
11753639	0	tyrosine	46,54	hepatocyte_growth_factor	12,36	tyrosine	hepatocyte growth factor	CHEBI:18186	3082	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Increase in hepatocyte_growth_factor receptor tyrosine kinase activity in renal_carcinoma cells is associated with increased motility partly through phosphoinositide 3-kinase activation .
11003664	0	tyrosine	55,63	hepatocyte_growth_factor-regulated_tyrosine_kinase_substrate	83,143	tyrosine	hepatocyte growth factor-regulated tyrosine kinase substrate	CHEBI:18186	9146	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Endosomal localization and receptor dynamics determine tyrosine phosphorylation of hepatocyte_growth_factor-regulated_tyrosine_kinase_substrate .
16409301	0	tyrosine	13,21	histone_deacetylase_1	46,67	tyrosine	histone deacetylase 1	CHEBI:18186	3065	Chemical	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	P210 Bcr-abl tyrosine kinase interaction with histone_deacetylase_1 modifies histone H4 acetylation and chromatin structure of chronic_myeloid_leukaemia haematopoietic progenitors .
1282811	0	tyrosine	8,16	hyk	25,28	tyrosine	hyk	CHEBI:18186	21687(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	A novel tyrosine kinase , hyk , expressed in murine embryonic stem cells .
16140274	0	tyrosine	82,90	inducible_nitric_oxide_synthase	36,67	tyrosine	inducible nitric oxide synthase	CHEBI:18186	4843	Chemical	Gene	kinases|compound|START_ENTITY kinases|amod|END_ENTITY	The regulation of the expression of inducible_nitric_oxide_synthase by Src-family tyrosine kinases mediated through MyD88-independent signaling pathways of Toll-like_receptor_4 .
10508408	0	tyrosine	48,56	insulin	75,82	tyrosine	insulin	CHEBI:18186	3630	Chemical	Gene	mutation|compound|START_ENTITY mutation|nmod|END_ENTITY	Structural consequences of the B5 histidine _ -- > _ tyrosine mutation in human insulin characterized by X-ray crystallography and conformational analysis .
11225657	0	tyrosine	29,37	insulin	12,19	tyrosine	insulin	CHEBI:18186	3630	Chemical	Gene	START_ENTITY|nsubj|receptor receptor|compound|END_ENTITY	Erythrocyte insulin receptor tyrosine kinase activity is increased in glyburide-treated patients with type 2 diabetes in good glycaemic control .
11856336	0	tyrosine	30,38	insulin	55,62	tyrosine	insulin	CHEBI:18186	3630	Chemical	Gene	action|nmod|START_ENTITY phosphatases|nsubj|action phosphatases|nmod|transduction transduction|compound|END_ENTITY	Coordinated action of protein tyrosine phosphatases in insulin signal transduction .
1473267	0	tyrosine	39,47	insulin	58,65	tyrosine	insulin	CHEBI:18186	3630	Chemical	Gene	inhibitors|nmod|START_ENTITY Effect|nmod|inhibitors kinase|nsubj|Effect kinase|nmod|END_ENTITY	Effect of inhibitors and activators of tyrosine kinase on insulin imprinting in Tetrahymena .
15896785	0	tyrosine	26,34	insulin	55,62	tyrosine	insulin	CHEBI:18186	3630	Chemical	Gene	phosphatase|amod|START_ENTITY Knock-down|nmod|phosphatase induces|nsubj|Knock-down induces|dobj|resistance resistance|compound|END_ENTITY	Knock-down of LAR protein tyrosine phosphatase induces insulin resistance .
15992069	0	tyrosine	8,16	insulin	45,52	tyrosine	insulin	CHEBI:18186	3630	Chemical	Gene	phosphatases|compound|START_ENTITY phosphatases|dep|role role|nmod|action action|compound|END_ENTITY	Protein tyrosine phosphatases : their role in insulin action and potential as drug targets .
16129690	4	tyrosine	848,856	insulin	888,895	tyrosine	insulin	CHEBI:18186	3630	Chemical	Gene	phosphorylation|amod|START_ENTITY sensitivity|nmod|phosphorylation reduced|dobj|sensitivity reduced|nmod|END_ENTITY	Inhibition of serine 307 phosphorylation by rapamycin mimicked type 2 diabetes and reduced the sensitivity of IRS1 tyrosine phosphorylation in response to insulin , while stimulation of the phosphorylation by okadaic acid , in cells from patients with type 2 diabetes , rescued cells from insulin resistance .
16614815	0	tyrosine	9,17	insulin	71,78	tyrosine	insulin	CHEBI:18186	3630	Chemical	Gene	Arg620Trp|amod|START_ENTITY regulates|nsubj|Arg620Trp regulates|dobj|autoimmunity autoimmunity|compound|END_ENTITY	Lymphoid tyrosine phosphatase -LRB- LYP/PTPN22 -RRB- Arg620Trp variant regulates insulin autoimmunity and progression to type 1 diabetes .
1703148	0	tyrosine	105,113	insulin	88,95	tyrosine	insulin	CHEBI:18186	3630	Chemical	Gene	START_ENTITY|nsubj|analysis analysis|nmod|cascade cascade|nmod|receptor receptor|compound|END_ENTITY	Two-dimensional phosphopeptide analysis of the autophosphorylation cascade of a soluble insulin receptor tyrosine kinase .
2026743	0	tyrosine	18,26	insulin	75,82	tyrosine	insulin	CHEBI:18186	3630	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|nmod|parallel parallel|nmod|END_ENTITY	Insulin-sensitive tyrosine kinase activity changes in parallel with plasma insulin and glucose concentrations in humans .
22493522	0	tyrosine	74,82	insulin	57,64	tyrosine	insulin	CHEBI:18186	3630	Chemical	Gene	START_ENTITY|nsubj|receptor receptor|compound|END_ENTITY	Molecular docking studies of banana flower flavonoids as insulin receptor tyrosine kinase activators as a cure for diabetes_mellitus .
2250023	0	tyrosine	17,25	insulin	57,64	tyrosine	insulin	CHEBI:18186	3630	Chemical	Gene	START_ENTITY|dobj|residues residues|dep|stimulation stimulation|compound|END_ENTITY	Insulin receptor tyrosine residues 1162 and 1163 control insulin stimulation of myristoyl-diacylglycerol generation and subsequent activation of glucose transport .
22572797	0	tyrosine	151,159	insulin	58,65	tyrosine	insulin	CHEBI:18186	3630	Chemical	Gene	products|amod|START_ENTITY addition|nmod|products cross-linking|nmod|addition modifications|dep|cross-linking modifications|nmod|aggregates aggregates|nmod|END_ENTITY	Chemical modifications in aggregates of recombinant human insulin induced by metal-catalyzed oxidation : covalent cross-linking via michael addition to tyrosine oxidation products .
2334426	0	tyrosine	75,83	insulin	58,65	tyrosine	insulin	CHEBI:18186	3630	Chemical	Gene	START_ENTITY|nsubj|Expression Expression|nmod|receptor receptor|compound|END_ENTITY	Expression , purification and characterization of a 41 kDa insulin receptor tyrosine kinase domain .
24264858	0	tyrosine	16,24	insulin	59,66	tyrosine	insulin	CHEBI:18186	3630	Chemical	Gene	Role|nmod|START_ENTITY phosphatases|nsubj|Role phosphatases|nmod|modulation modulation|nmod|signaling signaling|compound|END_ENTITY	Role of protein tyrosine phosphatases in the modulation of insulin signaling and their implication in the pathogenesis of obesity-linked_insulin_resistance .
3001059	0	tyrosine	139,147	insulin	61,68	tyrosine	insulin	CHEBI:18186	3630	Chemical	Gene	START_ENTITY|nsubj|phosphorylation phosphorylation|nmod|progesterone_receptor progesterone_receptor|nmod|END_ENTITY	Differential phosphorylation of the progesterone_receptor by insulin , epidermal_growth_factor , and platelet-derived growth factor receptor tyrosine protein kinases .
3024008	0	tyrosine	49,57	insulin	28,35	tyrosine	insulin	CHEBI:18186	3630	Chemical	Gene	activity|amod|START_ENTITY stimulate|dobj|activity allows|xcomp|stimulate allows|dobj|END_ENTITY	A chimaeric receptor allows insulin to stimulate tyrosine kinase activity of epidermal_growth_factor_receptor .
3100537	0	tyrosine	69,77	insulin	6,13	tyrosine	insulin	CHEBI:18186	3630	Chemical	Gene	START_ENTITY|nsubj|receptors receptors|compound|END_ENTITY	Human insulin receptors mutated at the ATP-binding site lack protein tyrosine kinase activity and fail to mediate postreceptor effects of insulin .
5075226	0	tyrosine	39,47	insulin	85,92	tyrosine	insulin	CHEBI:18186	3630	Chemical	Gene	residues|compound|START_ENTITY effect|nmod|residues effect|nmod|activity activity|nmod|END_ENTITY	The effect of iodination of particular tyrosine residues on the hormonal activity of insulin .
5893923	2	tyrosine	68,76	insulin	93,100	tyrosine	insulin	CHEBI:18186	3630	Chemical	Gene	residues|amod|START_ENTITY bonding|nmod|residues bonding|nmod|molecule molecule|compound|END_ENTITY	Hydrogen bonding of tyrosine residues in the insulin molecule .
7535775	3	tyrosine	487,495	insulin	556,563	tyrosine	insulin	CHEBI:18186	3630	Chemical	Gene	phosphorylation|amod|START_ENTITY studied|dobj|phosphorylation studied|nmod|cells cells|acl|expressing expressing|dobj|receptors receptors|compound|END_ENTITY	We studied the tyrosine phosphorylation of p95vav in hematopoietic cells expressing insulin receptors .
7662232	0	tyrosine	100,108	insulin	45,52	tyrosine	insulin	CHEBI:18186	3630	Chemical	Gene	activity|amod|START_ENTITY changes|nmod|activity load|nmod|changes improves|nmod|load improves|dobj|responses responses|compound|END_ENTITY	Doxazosin lowers blood pressure and improves insulin responses to a glucose load with no changes in tyrosine kinase activity or insulin binding .
7759507	1	tyrosine	261,269	insulin	244,251	tyrosine	insulin	CHEBI:18186	3630	Chemical	Gene	START_ENTITY|nsubj|Transgenic_mice Transgenic_mice|acl:relcl|overexpress overexpress|ccomp|used used|xcomp|study study|dobj|relationship relationship|nmod|receptor receptor|compound|END_ENTITY	Transgenic_mice which overexpress kinase-deficient human insulin receptors in muscle were used to study the relationship between insulin receptor tyrosine kinase and the in vivo activation of several downstream signaling pathways .
7846115	0	tyrosine	35,43	insulin	18,25	tyrosine	insulin	CHEBI:18186	3630	Chemical	Gene	START_ENTITY|nsubj|Inhibitors Inhibitors|nmod|receptor receptor|compound|END_ENTITY	Inhibitors of the insulin receptor tyrosine kinase .
8048939	2	tyrosine	417,425	insulin	400,407	tyrosine	insulin	CHEBI:18186	3630	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Using 19-22 day fetal rat lung , we studied the effect of culture for 48 hours under conditions of low -LRB- 10mM -RRB- and high -LRB- 100mM -RRB- glucose with and without added insulin on insulin receptor tyrosine kinase activity , mRNA abundance , and glucose uptake .
8529763	0	tyrosine	28,36	insulin	11,18	tyrosine	insulin	CHEBI:18186	3630	Chemical	Gene	START_ENTITY|nsubj|Changes Changes|nmod|receptor receptor|compound|END_ENTITY	Changes in insulin receptor tyrosine kinase activity associated with metformin treatment of type 2 diabetes .
8562311	0	tyrosine	8,16	insulin	27,34	tyrosine	insulin	CHEBI:18186	3630	Chemical	Gene	Role|nmod|START_ENTITY kinase|nsubj|Role kinase|nmod|release release|compound|END_ENTITY	Role of tyrosine kinase in insulin release in an insulin secreting cell line -LRB- INS-1 -RRB- .
8562311	0	tyrosine	8,16	insulin	49,56	tyrosine	insulin	CHEBI:18186	3630	Chemical	Gene	Role|nmod|START_ENTITY kinase|nsubj|Role kinase|nmod|release release|nmod|line line|compound|END_ENTITY	Role of tyrosine kinase in insulin release in an insulin secreting cell line -LRB- INS-1 -RRB- .
9302374	0	tyrosine	61,69	insulin	143,150	tyrosine	insulin	CHEBI:18186	3630	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|syndromes syndromes|nmod|resistance resistance|compound|END_ENTITY	Expression of the putative inhibitor of the insulin_receptor tyrosine kinase PC-1 in dermal fibroblasts from patients with syndromes of severe insulin resistance .
941747	0	tyrosine	45,53	insulin	17,24	tyrosine	insulin	CHEBI:18186	3630	Chemical	Gene	transport|nmod|START_ENTITY role|nmod|transport role|nmod|END_ENTITY	Possible role of insulin in the transport of tyrosine and tryptophan from blood to brain .
9443770	0	tyrosine	53,61	insulin	36,43	tyrosine	insulin	CHEBI:18186	3630	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|receptor receptor|compound|END_ENTITY	Bisoprolol and captopril effects on insulin receptor tyrosine kinase activity in essential hypertension .
9490500	0	tyrosine	76,84	insulin	105,112	tyrosine	insulin	CHEBI:18186	3630	Chemical	Gene	beta-subunits|nmod|START_ENTITY structure|nmod|beta-subunits symmetry|nmod|structure kinase|nsubj|symmetry kinase|nmod|peptides peptides|compound|END_ENTITY	-LSB- The internal symmetry of the primary structure of the beta-subunits of the tyrosine kinase receptors in insulin superfamily peptides and its relation to their functional activity -RSB- .
9759855	0	tyrosine	162,170	insulin	104,111	tyrosine	insulin	CHEBI:18186	3630	Chemical	Gene	activity|compound|START_ENTITY inhibitors|nmod|activity mimicking|nmod|inhibitors modulates|advcl|mimicking modulates|nmod|END_ENTITY	Epidermal_growth_factor -LRB- EGF -RRB- modulates fetal thymocyte growth and differentiation : partial reversal by insulin , mimicking by specific inhibitors of EGF receptor tyrosine kinase activity , and differential expression of CD45 phosphatase isotypes .
10926934	0	tyrosine	64,72	insulin-like_growth_factor-1_receptor	26,63	tyrosine	insulin-like growth factor-1 receptor	CHEBI:18186	3480	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	c-Crk , a substrate of the insulin-like_growth_factor-1_receptor tyrosine kinase , functions as an early signal mediator in the adipocyte differentiation process .
15334055	0	tyrosine	67,75	insulin-like_growth_factor-1_receptor	99,136	tyrosine	insulin-like growth factor-1 receptor	CHEBI:18186	3480	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	The cyclolignan_PPP induces activation loop-specific inhibition of tyrosine phosphorylation of the insulin-like_growth_factor-1_receptor .
18981172	0	tyrosine	100,108	insulin-like_growth_factor-1_receptor	62,99	tyrosine	insulin-like growth factor-1 receptor	CHEBI:18186	25718(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Glutamate acting on N-methyl-D-aspartate receptors attenuates insulin-like_growth_factor-1_receptor tyrosine phosphorylation and its survival signaling properties in rat hippocampal neurons .
19166817	0	tyrosine	52,60	insulin-like_growth_factor-1_receptor	14,51	tyrosine	insulin-like growth factor-1 receptor	CHEBI:18186	3480	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Inhibitors of insulin-like_growth_factor-1_receptor tyrosine kinase are preferentially cytotoxic to nutrient-deprived pancreatic_cancer cells .
19394223	0	tyrosine	133,141	insulin-like_growth_factor-1_receptor	86,123	tyrosine	insulin-like growth factor-1 receptor	CHEBI:18186	3480	Chemical	Gene	kinase|amod|START_ENTITY kinase|amod|END_ENTITY	Discovery of 3,5-disubstituted-1H-pyrrolo -LSB- 2,3-b -RSB- pyridines as potent inhibitors of the insulin-like_growth_factor-1_receptor -LRB- IGF-1R -RRB- tyrosine kinase .
21775140	0	tyrosine	102,110	insulin-like_growth_factor-1_receptor	64,101	tyrosine	insulin-like growth factor-1 receptor	CHEBI:18186	3480	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Discovery of novel imidazo -LSB- 1,2-a -RSB- pyridines as inhibitors of the insulin-like_growth_factor-1_receptor tyrosine kinase .
8876252	0	tyrosine	21,29	insulin-like_growth_factor-1_receptor	53,90	tyrosine	insulin-like growth factor-1 receptor	CHEBI:18186	16001(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Estradiol stimulates tyrosine phosphorylation of the insulin-like_growth_factor-1_receptor and insulin_receptor_substrate-1 in the uterus .
7476307	0	tyrosine	156,164	insulin-like_growth_factor-I	118,146	tyrosine	insulin-like growth factor-I	CHEBI:18186	3479	Chemical	Gene	kinases|amod|START_ENTITY kinases|compound|END_ENTITY	Role of the time factor in signaling specificity : application to mitogenic and metabolic signaling by the insulin and insulin-like_growth_factor-I receptor tyrosine kinases .
7493944	0	tyrosine	16,24	insulin-like_growth_factor-I_receptor	46,83	tyrosine	insulin-like growth factor-I receptor	CHEBI:18186	16001(Tax:10090)	Chemical	Gene	domain|amod|START_ENTITY role|nmod|domain role|nmod|END_ENTITY	The role of the tyrosine kinase domain of the insulin-like_growth_factor-I_receptor in intracellular signaling , cellular proliferation , and tumorigenesis .
7798258	0	tyrosine	106,114	insulin-like_growth_factor-I_receptor	46,83	tyrosine	insulin-like growth factor-I receptor	CHEBI:18186	3480	Chemical	Gene	mutations|nmod|START_ENTITY END_ENTITY|nmod|mutations	Mitogenicity and transforming activity of the insulin-like_growth_factor-I_receptor with mutations in the tyrosine kinase domain .
22359227	0	tyrosine	124,132	insulin-like_growth_factor_1	86,114	tyrosine	insulin-like growth factor 1	CHEBI:18186	3479	Chemical	Gene	START_ENTITY|nsubj|mutations mutations|nmod|lung_cancer lung_cancer|nmod|receptor receptor|amod|END_ENTITY	Epidermal_growth_factor_receptor and K-Ras mutations and resistance of lung_cancer to insulin-like_growth_factor_1 receptor tyrosine kinase inhibitors .
7622449	0	tyrosine	81,89	insulin-like_growth_factor_1	97,125	tyrosine	insulin-like growth factor 1	CHEBI:18186	24482(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	G beta gamma subunits mediate mitogen-activated protein kinase activation by the tyrosine kinase insulin-like_growth_factor_1 receptor .
10102697	0	tyrosine	79,87	insulin_receptor	48,64	tyrosine	insulin receptor	CHEBI:18186	24954(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Islet transplantation restores normal levels of insulin_receptor and substrate tyrosine phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle and myocardium of streptozocin-induced diabetic rats .
10212829	0	tyrosine	40,48	insulin_receptor	90,106	tyrosine	insulin receptor	CHEBI:18186	24954(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Inhibition of the transmembrane protein tyrosine phosphatase lar by 3S-peptide-I enhances insulin_receptor phosphorylation in intact cells .
10216198	0	tyrosine	16,24	insulin_receptor	48,64	tyrosine	insulin receptor	CHEBI:18186	24954(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Insulin induces tyrosine phosphorylation of the insulin_receptor and SHC , and SHC/GRB2 association in cerebellum but not in forebrain cortex of rats .
10480612	0	tyrosine	48,56	insulin_receptor	31,47	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Impaired glucose transport and insulin_receptor tyrosine phosphorylation in skeletal muscle from obese women with gestational_diabetes .
10634928	0	tyrosine	124,132	insulin_receptor	97,113	tyrosine	insulin receptor	CHEBI:18186	24954(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Insulin-induced Ca -LRB- 2 + -RRB- entry in hepatocytes is important for PI 3-kinase activation , but not for insulin_receptor and IRS-1 tyrosine phosphorylation .
10802154	0	tyrosine	37,45	insulin_receptor	20,36	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Bradykinin enhances insulin_receptor tyrosine kinase in 32D cells reconstituted with bradykinin and insulin signaling pathways .
10830518	0	tyrosine	4,12	insulin_receptor	44,60	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	The tyrosine kinase activity of the chicken insulin_receptor is similar to that of the human insulin_receptor .
10848643	0	tyrosine	49,57	insulin_receptor	77,93	tyrosine	insulin receptor	CHEBI:18186	24954(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Calorie restriction increases insulin-stimulated tyrosine phosphorylation of insulin_receptor and insulin_receptor_substrate-1 in rat skeletal muscle .
10978177	0	tyrosine	24,32	insulin_receptor	68,84	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	sites|amod|START_ENTITY sites|nmod|END_ENTITY	Identification of major tyrosine phosphorylation sites in the human insulin_receptor substrate Gab-1 by insulin_receptor kinase in vitro .
11124964	0	tyrosine	91,99	insulin_receptor	74,90	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Crystallographic and solution studies of an activation loop mutant of the insulin_receptor tyrosine kinase : insights into kinase mechanism .
11141047	0	tyrosine	34,42	insulin_receptor	17,33	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Ethanol inhibits insulin_receptor tyrosine kinase .
11158333	0	tyrosine	112,120	insulin_receptor	142,158	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	dephosphorylation|amod|START_ENTITY dephosphorylation|nmod|END_ENTITY	Distinct functions of the two protein tyrosine phosphatase domains of LAR -LRB- leukocyte common antigen-related -RRB- on tyrosine dephosphorylation of insulin_receptor .
11467416	0	tyrosine	86,94	insulin_receptor	69,85	tyrosine	insulin receptor	CHEBI:18186	16337(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Genetic mapping and functional studies of a natural inhibitor of the insulin_receptor tyrosine kinase : the mouse ortholog of human alpha2-HS_glycoprotein .
12477518	0	tyrosine	44,52	insulin_receptor	74,90	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|gene gene|compound|END_ENTITY	A C/T single nucleotide polymorphism at the tyrosine kinase domain of the insulin_receptor gene is associated with polycystic_ovary_syndrome .
12898468	0	tyrosine	80,88	insulin_receptor	63,79	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Physical exercise enhances protein_kinase_C_delta activity and insulin_receptor tyrosine phosphorylation in diabetes-prone_psammomys_obesus .
1445389	0	tyrosine	25,33	insulin_receptor	57,73	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Cholera toxin diminishes tyrosine kinase activity of the insulin_receptor .
15135305	0	tyrosine	96,104	insulin_receptor	79,95	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Metformin -LRB- Glucophage -RRB- inhibits tyrosine phosphatase activity to stimulate the insulin_receptor tyrosine kinase .
15169905	0	tyrosine	102,110	insulin_receptor	130,146	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|proteins proteins|compound|END_ENTITY	Suppressor_of_cytokine_signaling_1 -LRB- SOCS-1 -RRB- and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin_receptor substrate proteins by discrete mechanisms .
15998256	0	tyrosine	56,64	insulin_receptor	84,100	tyrosine	insulin receptor	CHEBI:18186	100766818	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	H2O2-induced phosphorylation of ERK1/2 and PKB requires tyrosine kinase activity of insulin_receptor and c-Src .
1607076	0	tyrosine	34,42	insulin_receptor	60,76	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|gene gene|compound|END_ENTITY	NIDDM associated with mutation in tyrosine kinase domain of insulin_receptor gene .
16132709	0	tyrosine	37,45	insulin_receptor	20,36	tyrosine	insulin receptor	CHEBI:18186	100008911(Tax:9986)	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of heart insulin_receptor tyrosine kinase activity by magnesium and spermine .
16235045	0	tyrosine	75,83	insulin_receptor	107,123	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	The vanadyl -LRB- VO2 + -RRB- chelate bis -LRB- acetylacetonato -RRB- oxovanadium -LRB- IV -RRB- potentiates tyrosine phosphorylation of the insulin_receptor .
16626396	0	tyrosine	107,115	insulin_receptor	90,106	tyrosine	insulin receptor	CHEBI:18186	16337(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Metallothionein antagonizes aging-induced cardiac_contractile_dysfunction : role of PTP1B , insulin_receptor tyrosine phosphorylation and Akt .
1846101	0	tyrosine	59,67	insulin_receptor	42,58	tyrosine	insulin receptor	CHEBI:18186	24954(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Diabetes-associated_impairment of hepatic insulin_receptor tyrosine kinase activity : a study of mechanisms .
1848794	0	tyrosine	108,116	insulin_receptor	91,107	tyrosine	insulin receptor	CHEBI:18186	24954(Tax:10116)	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Lipid-induced insulin resistance in cultured hepatoma cells is associated with a decreased insulin_receptor tyrosine kinase activity .
1890161	0	tyrosine	18,26	insulin_receptor	48,64	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	A mutation in the tyrosine kinase domain of the insulin_receptor associated with insulin resistance in an obese woman .
1964389	0	tyrosine	74,82	insulin_receptor	57,73	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	A 180,000 molecular weight glycoprotein substrate of the insulin_receptor tyrosine kinase is present in human placenta and in rat liver , muscle , heart and brain plasma membrane preparations .
19895792	0	tyrosine	10,18	insulin_receptor	40,56	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	START_ENTITY|dobj|activation activation|nmod|END_ENTITY	Prolonged tyrosine kinase activation of insulin_receptor by pY27-caveolin-2 .
2002058	0	tyrosine	66,74	insulin_receptor	97,113	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|gene gene|compound|END_ENTITY	Insulin resistance and diabetes due to different mutations in the tyrosine kinase domain of both insulin_receptor gene alleles .
2137339	0	tyrosine	70,78	insulin_receptor	102,118	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Hepatocyte plasma membrane ECTO-ATPase -LRB- pp120/HA4 -RRB- is a substrate for tyrosine kinase activity of the insulin_receptor .
2158467	0	tyrosine	48,56	insulin_receptor	31,47	tyrosine	insulin receptor	CHEBI:18186	24954(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Activation Activation|nmod|END_ENTITY	Activation of liver and muscle insulin_receptor tyrosine kinase activity during in vivo insulin administration in rats .
2180980	0	tyrosine	10,18	insulin_receptor	42,58	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Defect in tyrosine kinase activity of the insulin_receptor from a patient with insulin resistance and acanthosis nigricans .
22189999	0	tyrosine	105,113	insulin_receptor	135,151	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|gene gene|compound|END_ENTITY	Characterisation of adiponectin multimers and the IGF axis in humans with a heterozygote mutation in the tyrosine kinase domain of the insulin_receptor gene .
2339989	0	tyrosine	59,67	insulin_receptor	91,107	tyrosine	insulin receptor	CHEBI:18186	24954(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Concanavalin_A-induced receptor aggregation stimulates the tyrosine kinase activity of the insulin_receptor in intact cells .
24568043	0	tyrosine	82,90	insulin_receptor	108,124	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|gene gene|compound|END_ENTITY	Polycystic_ovary_syndrome : association of a C/T single nucleotide polymorphism at tyrosine kinase domain of insulin_receptor gene with pathogenesis among lean Japanese women .
2544997	0	tyrosine	49,57	insulin_receptor	79,95	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Human diabetes associated with a deletion of the tyrosine kinase domain of the insulin_receptor .
2544998	0	tyrosine	49,57	insulin_receptor	79,95	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Human diabetes associated with a mutation in the tyrosine kinase domain of the insulin_receptor .
2550343	0	tyrosine	100,108	insulin_receptor	83,99	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Insulin action is mimicked by polyclonal antireceptor antibodies that activate the insulin_receptor tyrosine kinase .
2553727	0	tyrosine	117,125	insulin_receptor	100,116	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Monoclonal antibodies mimic insulin activation of ribosomal protein S6 kinase without activation of insulin_receptor tyrosine kinase .
2647469	0	tyrosine	79,87	insulin_receptor	62,78	tyrosine	insulin receptor	CHEBI:18186	16337(Tax:10090)	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	The insulin-mimetic effect of vanadate is not correlated with insulin_receptor tyrosine kinase activity nor phosphorylation in mouse diaphragm in vivo .
2719663	0	tyrosine	39,47	insulin_receptor	77,93	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	START_ENTITY|dobj|activity activity|nmod|END_ENTITY	Proteolytic generation of constitutive tyrosine kinase activity of the human insulin_receptor .
2833239	0	tyrosine	29,37	insulin_receptor	61,77	tyrosine	insulin receptor	CHEBI:18186	24954(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Hydrogen_peroxide stimulates tyrosine phosphorylation of the insulin_receptor and its tyrosine kinase activity in intact cells .
3004334	0	tyrosine	43,51	insulin_receptor	26,42	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Kinetic properties of the insulin_receptor tyrosine protein kinase : activation through an insulin-stimulated tyrosine-specific , intramolecular autophosphorylation .
3038872	0	tyrosine	35,43	insulin_receptor	18,34	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	residues|compound|START_ENTITY residues|compound|END_ENTITY	Identification of insulin_receptor tyrosine residues autophosphorylated in vitro .
3275643	0	tyrosine	39,47	insulin_receptor	22,38	tyrosine	insulin receptor	CHEBI:18186	24954(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification of the insulin_receptor tyrosine residues undergoing insulin-stimulated phosphorylation in intact rat hepatoma cells .
3360145	0	tyrosine	97,105	insulin_receptor	72,88	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Polylysine activates and alters the divalent cation requirements of the insulin_receptor protein tyrosine kinase .
3518707	0	tyrosine	10,18	insulin_receptor	38,54	tyrosine	insulin receptor	CHEBI:18186	24954(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Decreased tyrosine kinase activity of insulin_receptor isolated from rat adipocytes rendered insulin-resistant by catecholamine treatment in vitro .
3518947	0	tyrosine	32,40	insulin_receptor	15,31	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	residues|compound|START_ENTITY residues|compound|END_ENTITY	Replacement of insulin_receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose .
6368546	0	tyrosine	48,56	insulin_receptor	4,20	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	coupled|xcomp|START_ENTITY coupled|nsubjpass|END_ENTITY	The insulin_receptor of rat brain is coupled to tyrosine kinase activity .
6574482	0	tyrosine	47,55	insulin_receptor	30,46	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	kinase|amod|START_ENTITY kinase|amod|END_ENTITY	Phosphorylation activates the insulin_receptor tyrosine protein kinase .
6757253	0	tyrosine	19,27	insulin_receptor	51,67	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Insulin-stimulated tyrosine phosphorylation of the insulin_receptor in detergent extracts of human placental membranes .
7508912	0	tyrosine	132,140	insulin_receptor	115,131	tyrosine	insulin receptor	CHEBI:18186	24954(Tax:10116)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Glucose-induced translocation of protein_kinase_C isoforms in rat-1 fibroblasts is paralleled by inhibition of the insulin_receptor tyrosine kinase .
7523453	0	tyrosine	8,16	insulin_receptor	40,56	tyrosine	insulin receptor	CHEBI:18186	24954(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|activity activity|nmod|END_ENTITY	Reduced tyrosine kinase activity of the insulin_receptor in obesity-diabetes .
7543044	0	tyrosine	54,62	insulin_receptor	34,50	tyrosine	insulin receptor	CHEBI:18186	100766818	Chemical	Gene	phosphorylation|amod|START_ENTITY END_ENTITY|nmod|phosphorylation	The role of the NPXY motif in the insulin_receptor in tyrosine phosphorylation of insulin_receptor substrate-1 and Shc .
7543044	0	tyrosine	54,62	insulin_receptor	82,98	tyrosine	insulin receptor	CHEBI:18186	100766818	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	The role of the NPXY motif in the insulin_receptor in tyrosine phosphorylation of insulin_receptor substrate-1 and Shc .
7593251	0	tyrosine	91,99	insulin_receptor	65,81	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Combination of insulinomimetic agents H2O2 and vanadate enhances insulin_receptor mediated tyrosine phosphorylation of IRS-1 leading to IRS-1 association with the phosphatidylinositol 3-kinase .
7686917	0	tyrosine	31,39	insulin_receptor	14,30	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Inhibitors of insulin_receptor tyrosine kinase in fibroblasts from diverse patients with impaired insulin action : evidence for a novel mechanism of postreceptor insulin resistance .
7836517	0	tyrosine	4,12	insulin_receptor	34,50	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|gene gene|compound|END_ENTITY	The tyrosine kinase domain of the insulin_receptor gene is normal in women with hyperinsulinaemia and polycystic_ovary_syndrome .
7906861	0	tyrosine	83,91	insulin_receptor	59,75	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	level|amod|START_ENTITY END_ENTITY|nmod|level	Serum alpha_2-HS-glycoprotein is an inhibitor of the human insulin_receptor at the tyrosine kinase level .
8082780	0	tyrosine	72,80	insulin_receptor	102,118	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Functional properties of a heterozygous mutation -LRB- Arg1174 -- > Gln -RRB- in the tyrosine kinase domain of the insulin_receptor from a type A insulin resistant patient .
8083198	0	tyrosine	105,113	insulin_receptor	139,155	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	dephosphorylation|amod|START_ENTITY dephosphorylation|nmod|END_ENTITY	A synthetic tris-sulfotyrosyl_dodecapeptide analogue of the insulin_receptor 1146-kinase domain inhibits tyrosine dephosphorylation of the insulin_receptor in situ .
8093061	0	tyrosine	63,71	insulin_receptor	38,54	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Annexin I as a potential inhibitor of insulin_receptor protein tyrosine kinase .
8096518	0	tyrosine	87,95	insulin_receptor	123,139	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Substitution of glutamic_acid for alanine 1135 in the putative `` catalytic loop '' of the tyrosine kinase domain of the human insulin_receptor .
8190022	0	tyrosine	32,40	insulin_receptor	15,31	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	START_ENTITY|nsubj|Stimulation Stimulation|nmod|END_ENTITY	Stimulation of insulin_receptor tyrosine kinase activity by an amino terminal sequence of human growth hormone .
8380406	0	tyrosine	67,75	insulin_receptor	50,66	tyrosine	insulin receptor	CHEBI:18186	24954(Tax:10116)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	pp120/ecto-ATPase , an endogenous substrate of the insulin_receptor tyrosine kinase , is expressed as two variably spliced isoforms .
8393956	0	tyrosine	38,46	insulin_receptor	21,37	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	START_ENTITY|nsubj|Relationship Relationship|nmod|END_ENTITY	Relationship between insulin_receptor tyrosine kinase activity and internalization in monocytes of non-insulin-dependent_diabetes_mellitus patients .
8529629	0	tyrosine	42,50	insulin_receptor	74,90	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Isoproterenol inhibits insulin-stimulated tyrosine phosphorylation of the insulin_receptor without increasing its serine/threonine phosphorylation .
8571133	0	tyrosine	46,54	insulin_receptor	29,45	tyrosine	insulin receptor	CHEBI:18186	24954(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|inhibition inhibition|nmod|END_ENTITY	IRS-1-mediated inhibition of insulin_receptor tyrosine kinase activity in TNF-alpha - and obesity-induced insulin resistance .
8594980	0	tyrosine	48,56	insulin_receptor	31,47	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	A nonradioactive assay for the insulin_receptor tyrosine kinase : use in monitoring receptor kinase activity after activation of overexpressed protein_kinase_C_alpha and high glucose treatment .
8603747	0	tyrosine	56,64	insulin_receptor	39,55	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Diacylglycerol directly stimulates the insulin_receptor tyrosine kinase .
8777990	0	tyrosine	81,89	insulin_receptor	64,80	tyrosine	insulin receptor	CHEBI:18186	484990(Tax:9615)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Bradykinin enhances GLUT4 translocation through the increase of insulin_receptor tyrosine kinase in primary adipocytes : evidence that bradykinin stimulates the insulin signalling pathway .
8834239	0	tyrosine	21,29	insulin_receptor	51,67	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|gene gene|compound|END_ENTITY	SSCP analysis of the tyrosine kinase domain of the insulin_receptor gene : polymorphisms detected in South African black and white subjects .
8930123	0	tyrosine	145,153	insulin_receptor	120,136	tyrosine	insulin receptor	CHEBI:18186	24954(Tax:10116)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Phosphotyrosine specifies the phosphorylation by protein kinase CK2 of a peptide reproducing the activation loop of the insulin_receptor protein tyrosine kinase .
8969282	0	tyrosine	141,149	insulin_receptor	171,187	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Severe resistance to insulin and insulin-like_growth_factor-I in cells from a patient with leprechaunism as a result of two mutations in the tyrosine kinase domain of the insulin_receptor .
8986641	0	tyrosine	119,127	insulin_receptor	102,118	tyrosine	insulin receptor	CHEBI:18186	24954(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	The development of insulin resistance with high fat feeding in rats does not involve either decreased insulin_receptor tyrosine kinase activity or membrane glycoprotein PC-1 .
8986641	1	tyrosine	231,239	insulin_receptor	214,230	tyrosine	insulin receptor	CHEBI:18186	24954(Tax:10116)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Recent studies have suggested that the insulin_receptor tyrosine kinase inhibitor , membrane glycoprotein PC-1 , may play a role in certain insulin resistant states .
9109644	0	tyrosine	49,57	insulin_receptor	32,48	tyrosine	insulin receptor	CHEBI:18186	24954(Tax:10116)	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Chromium oligopeptide activates insulin_receptor tyrosine kinase activity .
9201698	0	tyrosine	25,33	insulin_receptor	57,73	tyrosine	insulin receptor	CHEBI:18186	24954(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Effect of cations on the tyrosine kinase activity of the insulin_receptor : inhibition by fluoride is magnesium dependent .
9243110	0	tyrosine	56,64	insulin_receptor	88,104	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Protein kinase C isoforms beta 1 and beta_2 inhibit the tyrosine kinase activity of the insulin_receptor .
9312016	0	tyrosine	52,60	insulin_receptor	35,51	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	START_ENTITY|nsubj|structure structure|nmod|END_ENTITY	Crystal structure of the activated insulin_receptor tyrosine kinase in complex with peptide substrate and ATP analog .
9345301	0	tyrosine	56,64	insulin_receptor	88,104	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Impact of mutations at different serine residues on the tyrosine kinase activity of the insulin_receptor .
9353167	0	tyrosine	50,58	insulin_receptor	33,49	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Bovine fetuin is an inhibitor of insulin_receptor tyrosine kinase .
9578588	0	tyrosine	148,156	insulin_receptor	131,147	tyrosine	insulin receptor	CHEBI:18186	3643	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Vanadyl_sulfate-stimulated glycogen synthesis is associated with activation of phosphatidylinositol 3-kinase and is independent of insulin_receptor tyrosine phosphorylation .
14583092	0	tyrosine	49,57	insulin_receptor_substrate-1	20,48	tyrosine	insulin receptor substrate-1	CHEBI:18186	3667	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Modulation of human insulin_receptor_substrate-1 tyrosine phosphorylation by protein kinase Cdelta .
18559242	0	tyrosine	107,115	insulin_receptor_substrate-1	55,83	tyrosine	insulin receptor substrate-1	CHEBI:18186	25467(Tax:10116)	Chemical	Gene	-RSB-|amod|START_ENTITY expression|nmod|-RSB- expression|nmod|END_ENTITY	-LSB- Bushen Huoxue Huayu Recipe up-regulates expression of insulin_receptor_substrate-1 and phosphorylation of tyrosine in adipose tissue in androgen sterilized rats -RSB- .
7512195	0	tyrosine	65,73	insulin_receptor_substrate-1	93,121	tyrosine	insulin receptor substrate-1	CHEBI:18186	100755710	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Activation of protein_kinase_C_alpha inhibits insulin-stimulated tyrosine phosphorylation of insulin_receptor_substrate-1 .
7544789	0	tyrosine	87,95	insulin_receptor_substrate-1	50,78	tyrosine	insulin receptor substrate-1	CHEBI:18186	16367(Tax:10090)	Chemical	Gene	kinases|compound|START_ENTITY kinases|amod|END_ENTITY	Interleukin-9 induces tyrosine phosphorylation of insulin_receptor_substrate-1 via JAK tyrosine kinases .
7588273	0	tyrosine	119,127	insulin_receptor_substrate-1	59,87	tyrosine	insulin receptor substrate-1	CHEBI:18186	25467(Tax:10116)	Chemical	Gene	association|nmod|START_ENTITY association|amod|END_ENTITY	Identification by mutation of the tyrosine residues in the insulin_receptor_substrate-1 affecting association with the tyrosine phosphatase 2C and phosphatidylinositol 3-kinase .
7646434	0	tyrosine	46,54	insulin_receptor_substrate-1	17,45	tyrosine	insulin receptor substrate-1	CHEBI:18186	3667	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Ethanol inhibits insulin_receptor_substrate-1 tyrosine phosphorylation and insulin-stimulated neuronal thread protein gene expression .
8626623	0	tyrosine	55,63	insulin_receptor_substrate-1	87,115	tyrosine	insulin receptor substrate-1	CHEBI:18186	25467(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Sphingomyelinase and ceramide suppress insulin-induced tyrosine phosphorylation of the insulin_receptor_substrate-1 .
8645156	0	tyrosine	105,113	insulin_receptor_substrate-1	133,161	tyrosine	insulin receptor substrate-1	CHEBI:18186	3667	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Growth inhibition signalled through the interleukin-4 / interleukin-13 receptor complex is associated with tyrosine phosphorylation of insulin_receptor_substrate-1 .
9335553	0	tyrosine	60,68	insulin_receptor_substrate-1	31,59	tyrosine	insulin receptor substrate-1	CHEBI:18186	3667	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Protein kinase C modulation of insulin_receptor_substrate-1 tyrosine phosphorylation requires serine 612 .
9334184	0	tyrosine	27,35	insulin_receptor_substrate-2	55,83	tyrosine	insulin receptor substrate-2	CHEBI:18186	8660	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Erythropoietin induces the tyrosine phosphorylation of insulin_receptor_substrate-2 .
15840294	0	tyrosine	67,75	insulin_receptor_substrate_1	15,43	tyrosine	insulin receptor substrate 1	CHEBI:18186	3667	Chemical	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of insulin_receptor_substrate_1 and phosphorylation of tyrosine in adipose tissue of polycystic_ovary_syndrome -RSB- .
23401856	0	tyrosine	20,28	insulin_receptor_substrate_1	44,72	tyrosine	insulin receptor substrate 1	CHEBI:18186	3667	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|nmod|END_ENTITY	C1-Ten is a protein tyrosine phosphatase of insulin_receptor_substrate_1 -LRB- IRS-1 -RRB- , regulating IRS-1 stability and muscle_atrophy .
7515062	0	tyrosine	57,65	insulin_receptor_substrate_1	21,49	tyrosine	insulin receptor substrate 1	CHEBI:18186	3667	Chemical	Gene	PTP2C|amod|START_ENTITY Dephosphorylation|nmod|PTP2C Dephosphorylation|nmod|END_ENTITY	Dephosphorylation of insulin_receptor_substrate_1 by the tyrosine phosphatase PTP2C .
7575404	0	tyrosine	23,31	insulin_receptor_substrate_1	51,79	tyrosine	insulin receptor substrate 1	CHEBI:18186	25467(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Angiotensin_II induces tyrosine phosphorylation of insulin_receptor_substrate_1 and its association with phosphatidylinositol 3-kinase in rat heart .
8754813	0	tyrosine	78,86	insulin_receptor_substrate_1	32,60	tyrosine	insulin receptor substrate 1	CHEBI:18186	3667	Chemical	Gene	sites|amod|START_ENTITY signaling|nmod|sites signaling|nmod|molecule molecule|amod|END_ENTITY	YMXM motifs and signaling by an insulin_receptor_substrate_1 molecule without tyrosine phosphorylation sites .
8824290	0	tyrosine	19,27	insulin_receptor_substrate_1	47,75	tyrosine	insulin receptor substrate 1	CHEBI:18186	3667	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Gastrin stimulates tyrosine phosphorylation of insulin_receptor_substrate_1 and its association with Grb2 and the phosphatidylinositol 3-kinase .
9139682	0	tyrosine	26,34	insulin_receptor_substrate_1	69,97	tyrosine	insulin receptor substrate 1	CHEBI:18186	25467(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Angiotensin_II stimulates tyrosine phosphorylation and activation of insulin_receptor_substrate_1 and protein-tyrosine_phosphatase_1D in vascular smooth muscle cells .
7499365	0	tyrosine	39,47	insulin_receptor_substrates_1_and_2	67,102	tyrosine	insulin receptor substrates 1 and 2	CHEBI:18186	3667;8660	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Interleukins 2 , 4 , 7 , and 15 stimulate tyrosine phosphorylation of insulin_receptor_substrates_1_and_2 in T cells .
10474125	0	tyrosine	74,82	insulinoma-associated_protein_2	36,67	tyrosine	insulinoma-associated protein 2	CHEBI:18186	5798	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|amod|END_ENTITY	T-cell mediated autoimmunity to the insulinoma-associated_protein_2 islet tyrosine phosphatase in type_1_diabetes_mellitus .
16472776	0	tyrosine	71,79	integrin_alpha1	18,33	tyrosine	integrin alpha1	CHEBI:18186	3672	Chemical	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification of integrin_alpha1 as an interacting protein of protein tyrosine phosphatase PRL-3 .
8174677	0	tyrosine	101,109	interleukin-11	78,92	tyrosine	interleukin-11	CHEBI:18186	16156(Tax:10090)	Chemical	Gene	kinase|amod|START_ENTITY kinase|amod|END_ENTITY	Identification of a 130-kilodalton tyrosine-phosphorylated protein induced by interleukin-11 as JAK2 tyrosine kinase , which associates with gp130 signal transducer .
15197346	0	tyrosine	39,47	interleukin-2	74,87	tyrosine	interleukin-2	CHEBI:18186	3558	Chemical	Gene	regulation|nmod|START_ENTITY kinase|nsubj|regulation kinase|dobj|END_ENTITY	Differential regulation of the protein tyrosine kinase activity following interleukin-2 -LRB- IL-2 -RRB- , interferron_gamma _ -LRB- IFN-gamma -RRB- and SRBC administration in brain_tumor-induced conditions : SRBC acting as a dual potentiator in regulating the cytokine profile .
2334739	0	tyrosine	67,75	interleukin-2	24,37	tyrosine	interleukin-2	CHEBI:18186	16183(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|END_ENTITY	Differential effects of interleukin-2 and interleukin-4 on protein tyrosine phosphorylation in factor-dependent murine T cells .
9013873	0	tyrosine	81,89	interleukin-6	120,133	tyrosine	interleukin-6	CHEBI:18186	3569	Chemical	Gene	phosphorylated|advmod|START_ENTITY phosphorylated|nmod|END_ENTITY	Vav is associated with signal transducing molecules gp130 , Grb2 and Erk2 , and is tyrosine phosphorylated in response to interleukin-6 .
1382699	0	tyrosine	48,56	interleukin-9	18,31	tyrosine	interleukin-9	CHEBI:18186	3578	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Recombinant human interleukin-9 induces protein tyrosine phosphorylation and synergizes with steel_factor to stimulate proliferation of the human factor-dependent cell line , M07e .
7822337	0	tyrosine	45,53	interleukin_4	5,18	tyrosine	interleukin 4	CHEBI:18186	3565	Chemical	Gene	phosphorylation|amod|START_ENTITY induce|dobj|phosphorylation induce|nsubj|END_ENTITY	Both interleukin_4 and interleukin_13 induce tyrosine phosphorylation of the 140-kDa subunit of the interleukin_4 receptor .
12697028	0	tyrosine	88,96	islet-cell_antigen_512	123,145	tyrosine	islet-cell antigen 512	CHEBI:18186	5798	Chemical	Gene	START_ENTITY|dobj|proteins proteins|amod|END_ENTITY	A novel strategy for the development of selective active-site inhibitors of the protein tyrosine phosphatase-like proteins islet-cell_antigen_512 -LRB- IA-2 -RRB- and phogrin -LRB- IA-2beta -RRB- .
15801842	0	tyrosine	89,97	jak2	84,88	tyrosine	jak2	CHEBI:18186	3717	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Identification of 1,2,3,4,5,6-hexabromocyclohexane as a small molecule inhibitor of jak2 tyrosine kinase autophosphorylation -LSB- correction of autophophorylation -RSB- .
10716931	0	tyrosine	31,39	kit	146,149	tyrosine	kit	CHEBI:18186	16590(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY mutation|nmod|kinase reveals|nsubj|mutation reveals|nmod|kit kit|acl|signaling signaling|advcl|affecting affecting|dobj|responses responses|compound|END_ENTITY	Point mutation in kit receptor tyrosine kinase reveals essential roles for kit signaling in spermatogenesis and oogenesis without affecting other kit responses .
10716931	0	tyrosine	31,39	kit	18,21	tyrosine	kit	CHEBI:18186	16590(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Point mutation in kit receptor tyrosine kinase reveals essential roles for kit signaling in spermatogenesis and oogenesis without affecting other kit responses .
10716931	0	tyrosine	31,39	kit	75,78	tyrosine	kit	CHEBI:18186	16590(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY mutation|nmod|kinase reveals|nsubj|mutation reveals|nmod|END_ENTITY	Point mutation in kit receptor tyrosine kinase reveals essential roles for kit signaling in spermatogenesis and oogenesis without affecting other kit responses .
22747577	0	tyrosine	39,47	kit	126,129	tyrosine	kit	CHEBI:18186	3815	Chemical	Gene	inhibitor|amod|START_ENTITY analysis|nmod|inhibitor treated|nsubj|analysis treated|ccomp|identifies identifies|dobj|genes genes|amod|END_ENTITY	Transcriptome and proteome analysis of tyrosine kinase inhibitor treated canine mast_cell_tumour cells identifies potentially kit signaling-dependent genes .
10233937	0	tyrosine	66,74	latent_membrane_protein_2	117,142	tyrosine	latent membrane protein 2	CHEBI:18186	17494212	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Epithelial cell adhesion to extracellular matrix proteins induces tyrosine phosphorylation of the Epstein-Barr_virus latent_membrane_protein_2 : a role for C-terminal Src kinase .
10087161	0	tyrosine	23,31	lck	18,21	tyrosine	lck	CHEBI:18186	3932	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|p56 p56|appos|END_ENTITY	Inhibition of p56 -LRB- lck -RRB- tyrosine kinase by isothiazolones .
10190908	0	tyrosine	24,32	lck	145,148	tyrosine	lck	CHEBI:18186	3932	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|receptor receptor|acl|signaling signaling|dobj|motifs motifs|acl:relcl|thymocytes thymocytes|advcl|limiting limiting|dobj|p56 p56|appos|END_ENTITY	ZAP-70 protein promotes tyrosine phosphorylation of T cell receptor signaling motifs -LRB- ITAMs -RRB- in immature CD4 -LRB- + -RRB- 8 -LRB- + -RRB- thymocytes with limiting p56 -LRB- lck -RRB- .
10400611	0	tyrosine	132,140	lck	18,21	tyrosine	lck	CHEBI:18186	3932	Chemical	Gene	phosphorylation|compound|START_ENTITY absence|nmod|phosphorylation herpesvirus_saimiri|nmod|absence protein|nmod|herpesvirus_saimiri the|nmod|protein kinase|nmod|the kinase|nsubj|Activation Activation|nmod|tyrosine-protein tyrosine-protein|compound|END_ENTITY	Activation of the lck tyrosine-protein kinase by the binding of the tip protein of herpesvirus_saimiri in the absence of regulatory tyrosine phosphorylation .
10458749	0	tyrosine	9,17	lck	172,175	tyrosine	lck	CHEBI:18186	16818(Tax:10090)	Chemical	Gene	phosphatase|compound|START_ENTITY regulates|nsubj|phosphatase regulates|parataxis|function function|nmod|p56 p56|appos|END_ENTITY	The CD45 tyrosine phosphatase regulates CD3-induced signal transduction and T cell development in recombinase-deficient mice : restoration of pre-TCR function by active p56 -LRB- lck -RRB- .
10602022	0	tyrosine	47,55	lck	67,70	tyrosine	lck	CHEBI:18186	16818(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|p56 p56|appos|END_ENTITY	Co-ordination of the expression of the protein tyrosine kinase p56 -LRB- lck -RRB- with the pre-T cell receptor during thymocyte development .
10683231	0	tyrosine	71,79	lck	87,90	tyrosine	lck	CHEBI:18186	3932	Chemical	Gene	domain|amod|START_ENTITY domain|compound|END_ENTITY	Kinetic analysis of the mass transport limited interaction between the tyrosine kinase lck SH2 domain and a phosphorylated peptide studied by a new cuvette-based surface plasmon resonance instrument .
10970857	0	tyrosine	36,44	lck	74,77	tyrosine	lck	CHEBI:18186	16818(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|mice mice|compound|END_ENTITY	Development of T-leukaemias in CD45 tyrosine phosphatase-deficient mutant lck mice .
11222499	0	tyrosine	29,37	lck	49,52	tyrosine	lck	CHEBI:18186	3932	Chemical	Gene	START_ENTITY|dobj|p56 p56|appos|END_ENTITY	A potential role for protein tyrosine kinase p56 -LRB- lck -RRB- in rheumatoid_arthritis synovial fluid T lymphocyte hyporesponsiveness .
11533187	0	tyrosine	27,35	lck	22,25	tyrosine	lck	CHEBI:18186	3932	Chemical	Gene	cells|amod|START_ENTITY cells|appos|END_ENTITY	Downregulation of p56 -LRB- lck -RRB- tyrosine kinase activity in T cells of squirrel monkeys -LRB- Saimiri_sciureus -RRB- correlates with the nontransforming and apathogenic properties of herpesvirus_saimiri in its natural host .
12083826	0	tyrosine	70,78	lck	66,69	tyrosine	lck	CHEBI:18186	3932	Chemical	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	The herpesvirus_saimiri tip484 and tip488 proteins both stimulate lck tyrosine protein kinase activity in vivo and in vitro .
1279202	0	tyrosine	74,82	lck	70,73	tyrosine	lck	CHEBI:18186	3932	Chemical	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Creation and characterization of temperature-sensitive mutants of the lck tyrosine protein kinase .
1383689	0	tyrosine	14,22	lck	10,13	tyrosine	lck	CHEBI:18186	3932	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Activated lck tyrosine protein kinase stimulates antigen-independent interleukin-2 production in T cells .
1408136	0	tyrosine	58,66	lck	54,57	tyrosine	lck	CHEBI:18186	3932	Chemical	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Functional analysis of the SH2 and SH3 domains of the lck tyrosine protein kinase .
1545804	0	tyrosine	46,54	lck	42,45	tyrosine	lck	CHEBI:18186	3932	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	tkl is the avian homolog of the mammalian lck tyrosine protein kinase gene .
1594248	0	tyrosine	68,76	lck	64,67	tyrosine	lck	CHEBI:18186	16818(Tax:10090)	Chemical	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Generation and characterization of transforming variants of the lck tyrosine protein kinase .
19325836	0	tyrosine	31,39	lck	18,21	tyrosine	lck	CHEBI:18186	3932	Chemical	Gene	START_ENTITY|nsubj|study study|nmod|protein protein|appos|END_ENTITY	QSAR study of p56 -LRB- lck -RRB- protein tyrosine kinase inhibitory activity of flavonoid derivatives using MLR and GA-PLS .
2118992	0	tyrosine	92,100	lck	88,91	tyrosine	lck	CHEBI:18186	16818(Tax:10090)	Chemical	Gene	kinase|amod|START_ENTITY kinase|amod|END_ENTITY	Cross-linking of T-cell surface molecules CD4 and CD8 stimulates phosphorylation of the lck tyrosine protein kinase at the autophosphorylation site .
21556564	0	tyrosine	16,24	lck	83,86	tyrosine	lck	CHEBI:18186	313050(Tax:10116)	Chemical	Gene	kinases|amod|START_ENTITY Deregulation|nmod|kinases Deregulation|dep|expression expression|nmod|END_ENTITY	Deregulation of tyrosine kinases in a rat macrophage tumor - ectopic expression of lck .
25139491	0	tyrosine	86,94	lck	81,84	tyrosine	lck	CHEBI:18186	3932	Chemical	Gene	kinase|amod|START_ENTITY p56|amod|kinase p56|appos|END_ENTITY	Damnacanthal inhibits the NF-kB/RIP -2 / caspase-1 signal pathway by inhibiting p56 -LRB- lck -RRB- tyrosine kinase .
2835736	0	tyrosine	22,30	lck	18,21	tyrosine	lck	CHEBI:18186	3932	Chemical	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of the lck tyrosine kinase gene in human colon_carcinoma and other non-lymphoid human tumor cell lines .
3257410	0	tyrosine	40,48	lck	62,65	tyrosine	lck	CHEBI:18186	3932	Chemical	Gene	message|amod|START_ENTITY message|appos|END_ENTITY	Expression of the human T-cell-specific tyrosine kinase YT16 -LRB- lck -RRB- message in leukemic T-cell lines .
7553885	0	tyrosine	34,42	lck	30,33	tyrosine	lck	CHEBI:18186	3932	Chemical	Gene	kinase|amod|START_ENTITY END_ENTITY|dobj|kinase	Phosphorylation of src family lck tyrosine kinase following interleukin-12 activation of human natural killer cells .
8441403	0	tyrosine	47,55	lck	115,118	tyrosine	lck	CHEBI:18186	16818(Tax:10090)	Chemical	Gene	protein|compound|START_ENTITY expression|nmod|protein effects|nmod|expression phosphatase|nsubj|effects phosphatase|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Differential effects of expression of the CD45 tyrosine protein phosphatase on the tyrosine phosphorylation of the lck , fyn , and c-src tyrosine protein kinases .
8441403	0	tyrosine	83,91	lck	115,118	tyrosine	lck	CHEBI:18186	16818(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Differential effects of expression of the CD45 tyrosine protein phosphatase on the tyrosine phosphorylation of the lck , fyn , and c-src tyrosine protein kinases .
8955183	0	tyrosine	75,83	lck	95,98	tyrosine	lck	CHEBI:18186	16818(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|p56 p56|appos|END_ENTITY	Lineage-specific control of superantigen-induced cell death by the protein tyrosine kinase p56 -LRB- lck -RRB- .
9645606	0	tyrosine	25,33	lck	20,23	tyrosine	lck	CHEBI:18186	16818(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Requirement Requirement|nmod|p56 p56|appos|END_ENTITY	Requirement for p56 -LRB- lck -RRB- tyrosine kinase activation in Th subset differentiation .
15821101	0	tyrosine	21,29	leptin	68,74	tyrosine	leptin	CHEBI:18186	16846(Tax:10090)	Chemical	Gene	Mechanism|nmod|START_ENTITY phosphatase|nsubj|Mechanism phosphatase|dobj|inhibition inhibition|nmod|signalling signalling|compound|END_ENTITY	Mechanism of protein tyrosine phosphatase 1B-mediated inhibition of leptin signalling .
22405067	0	tyrosine	43,51	leptin	14,20	tyrosine	leptin	CHEBI:18186	3952	Chemical	Gene	resistance|nmod|START_ENTITY resistance|compound|END_ENTITY	Modulation of leptin resistance by protein tyrosine phosphatases .
7685902	0	tyrosine	70,78	leukocyte_tyrosine_kinase	35,60	tyrosine	leukocyte tyrosine kinase	CHEBI:18186	4058	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Differently spliced cDNAs of human leukocyte_tyrosine_kinase receptor tyrosine kinase predict receptor proteins with and without a tyrosine kinase domain and a soluble receptor protein .
8910363	0	tyrosine	131,139	leukocyte_tyrosine_kinase	76,101	tyrosine	leukocyte tyrosine kinase	CHEBI:18186	17005(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY END_ENTITY|appos|kinase	Growth and survival signals transmitted via two distinct NPXY motifs within leukocyte_tyrosine_kinase , an insulin receptor-related tyrosine kinase .
11854294	0	tyrosine	46,54	lipoprotein_receptor-related_protein	90,126	tyrosine	lipoprotein receptor-related protein	CHEBI:18186	4035	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Platelet-derived growth factor -LRB- PDGF -RRB- - induced tyrosine phosphorylation of the low density lipoprotein_receptor-related_protein -LRB- LRP -RRB- .
1655406	0	tyrosine	51,59	ltk	4,7	tyrosine	ltk	CHEBI:18186	4058	Chemical	Gene	kinase|compound|START_ENTITY encodes|dobj|kinase encodes|nsubj|gene gene|compound|END_ENTITY	The ltk gene encodes a novel receptor-type protein tyrosine kinase .
8084603	0	tyrosine	19,27	ltk	6,9	tyrosine	ltk	CHEBI:18186	4058	Chemical	Gene	START_ENTITY|nsubj|receptor receptor|compound|END_ENTITY	Human ltk receptor tyrosine kinase binds to PLC-gamma_1 , PI3-K , GAP and Raf-1 in vivo .
8380920	0	tyrosine	45,53	ltk	27,30	tyrosine	ltk	CHEBI:18186	17005(Tax:10090)	Chemical	Gene	kinases|amod|START_ENTITY predict|dobj|kinases predict|nsubj|mRNAs mRNAs|compound|END_ENTITY	Four tissue-specific mouse ltk mRNAs predict tyrosine kinases that differ upstream of their transmembrane segment .
7789617	0	tyrosine	10,18	luteinizing_hormone-releasing_hormone	40,77	tyrosine	luteinizing hormone-releasing hormone	CHEBI:18186	25194(Tax:10116)	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|nmod|END_ENTITY	Effect of tyrosine kinase inhibitors on luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- - induced gonadotropin release from the anterior pituitary .
7914906	0	tyrosine	8,16	lymphocyte_function-associated_1	42,74	tyrosine	lymphocyte function-associated 1	CHEBI:18186	16408(Tax:10090)	Chemical	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Protein tyrosine kinase p56-Lck regulates lymphocyte_function-associated_1 adhesion molecule expression , granule exocytosis , and cytolytic effector function in a cloned T cell .
1372554	0	tyrosine	63,71	lyn	59,62	tyrosine	lyn	CHEBI:18186	81515(Tax:10116)	Chemical	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Selective effect of poly -LRB- lysine -RRB- on the enhancement of the lyn tyrosine protein kinase activity .
7722458	0	tyrosine	104,112	lyn	100,103	tyrosine	lyn	CHEBI:18186	4067	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The intracellular signal transduction mechanism of interleukin_5 in eosinophils : the involvement of lyn tyrosine kinase and the Ras-Raf-1-MEK-microtubule-associated_protein kinase pathway .
8892754	0	tyrosine	68,76	m-ehk2	11,17	tyrosine	m-ehk2	CHEBI:18186	13840(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Cloning of m-ehk2 from the murine inner ear , an eph family receptor tyrosine kinase expressed in the developing and adult cochlea .
11713269	0	tyrosine	149,157	mRor1	124,129	tyrosine	mRor1	CHEBI:18186	26563(Tax:10090)	Chemical	Gene	kinases|compound|START_ENTITY kinases|amod|END_ENTITY	Loss of mRor1 enhances the heart and skeletal_abnormalities in mRor2-deficient mice : redundant and pleiotropic functions of mRor1 and mRor2 receptor tyrosine kinases .
26584640	0	tyrosine	103,111	mTOR	131,135	tyrosine	mTOR	D014443	21977(Tax:10090)	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	mTORC2 promotes type_I_insulin-like_growth factor receptor and insulin_receptor activation through the tyrosine kinase activity of mTOR .
12672821	0	tyrosine	26,34	mammalian_enabled	58,75	tyrosine	mammalian enabled	CHEBI:18186	55740	Chemical	Gene	START_ENTITY|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Abl_interactor_1 promotes tyrosine 296 phosphorylation of mammalian_enabled -LRB- Mena -RRB- by c-Abl kinase .
19265433	0	tyrosine	53,61	manganese_superoxide_dismutase	22,52	tyrosine	manganese superoxide dismutase	CHEBI:18186	6648	Chemical	Gene	START_ENTITY|nsubj|Contribution Contribution|nmod|END_ENTITY	Contribution of human manganese_superoxide_dismutase tyrosine 34 to structure and catalysis .
10580107	0	tyrosine	99,107	matrix_metalloproteinase-9	43,69	tyrosine	matrix metalloproteinase-9	CHEBI:18186	4318	Chemical	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Human_immunodeficiency_virus-1-tat induces matrix_metalloproteinase-9 in monocytes through protein tyrosine phosphatase-mediated activation of nuclear transcription factor NF-kappaB .
20651331	0	tyrosine	55,63	membrane-type_1_matrix_metalloproteinase	14,54	tyrosine	membrane-type 1 matrix metalloproteinase	CHEBI:18186	17387(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Inhibition of membrane-type_1_matrix_metalloproteinase tyrosine phosphorylation blocks_tumor progression in mice .
18621744	0	tyrosine	9,17	membrane_type_1-matrix_metalloproteinase	37,77	tyrosine	membrane type 1-matrix metalloproteinase	CHEBI:18186	17387(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Impaired tyrosine phosphorylation of membrane_type_1-matrix_metalloproteinase reduces tumor cell proliferation in three-dimensional matrices and abrogates_tumor growth in mice .
12884290	0	tyrosine	17,25	mer	4,7	tyrosine	mer	CHEBI:18186	17289(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|receptor receptor|compound|END_ENTITY	The mer receptor tyrosine kinase : expression and function suggest a role in innate immunity .
9772164	0	tyrosine	57,65	methylmalonyl-CoA_mutase	77,101	tyrosine	methylmalonyl-CoA mutase	CHEBI:18186	4594	Chemical	Gene	residue|compound|START_ENTITY residue|nmod|END_ENTITY	Stabilization of radical intermediates by an active-site tyrosine residue in methylmalonyl-CoA_mutase .
7682411	0	tyrosine	22,30	microtubule-associated_protein	50,80	tyrosine	microtubule-associated protein	CHEBI:18186	51115	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Direct stimulation by tyrosine phosphorylation of microtubule-associated_protein -LRB- MAP -RRB- kinase activity by granulocyte-macrophage_colony-stimulating_factor in human neutrophils .
1655769	0	tyrosine	109,117	microtubule-associated_protein-2	161,193	tyrosine	microtubule-associated protein-2	CHEBI:18186	17756(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|kinase kinase|amod|END_ENTITY	Stimulation of B-cells via the membrane immunoglobulin receptor or with phorbol_myristate 13-acetate induces tyrosine phosphorylation and activation of a 42-kDa microtubule-associated_protein-2 kinase .
26212014	0	tyrosine	13,21	mule	41,45	tyrosine	mule	D014443	10075	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Syk-mediated tyrosine phosphorylation of mule promotes TNF-induced JNK activation and cell death .
11007902	0	tyrosine	98,106	myelin-associated_glycoprotein	59,89	tyrosine	myelin-associated glycoprotein	CHEBI:18186	17136(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Severe hypomyelination of the murine CNS in the absence of myelin-associated_glycoprotein and fyn tyrosine kinase .
11553306	0	tyrosine	140,148	myelin-associated_glycoprotein	101,131	tyrosine	myelin-associated glycoprotein	CHEBI:18186	17136(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Transplantation of neural precursor cells into the dysmyelinated CNS of mutant mice deficient in the myelin-associated_glycoprotein and Fyn tyrosine kinase .
12846735	0	tyrosine	19,27	nephrin	47,54	tyrosine	nephrin	CHEBI:18186	4868	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Clustering-induced tyrosine phosphorylation of nephrin by Src family kinases .
18256598	0	tyrosine	10,18	nephrin	38,45	tyrosine	nephrin	CHEBI:18186	4868	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Decreased tyrosine phosphorylation of nephrin in rat and human nephrosis .
21306299	0	tyrosine	98,106	nephrin	126,133	tyrosine	nephrin	CHEBI:18186	54631(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Trans-interaction of nephrin and Neph1/Neph3 induces cell adhesion that associates with decreased tyrosine phosphorylation of nephrin .
23188823	0	tyrosine	29,37	nephrin	21,28	tyrosine	nephrin	CHEBI:18186	4868	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|END_ENTITY	Direct regulation of nephrin tyrosine phosphorylation by Nck adaptor proteins .
26644409	0	tyrosine	42,50	nephrin	34,41	tyrosine	nephrin	D014443	54631(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Shp2 associates with and enhances nephrin tyrosine phosphorylation and is necessary for foot process spreading in mouse models of podocyte injury .
21357692	0	tyrosine	38,46	nephrocystin-1	66,80	tyrosine	nephrocystin-1	CHEBI:18186	4867	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Nephrocystin-4 regulates Pyk2-induced tyrosine phosphorylation of nephrocystin-1 to control targeting to monocilia .
1685673	0	tyrosine	106,114	neu	93,96	tyrosine	neu	CHEBI:18186	13866(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Down-regulation of cellular platelet-derived growth factor receptors induced by an activated neu receptor tyrosine kinase .
7582098	0	tyrosine	82,90	neu	78,81	tyrosine	neu	CHEBI:18186	13866(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Lines of murine oligodendroglial precursor cells immortalized by an activated neu tyrosine kinase show distinct degrees of interaction with axons in vitro and in vivo .
9685399	0	tyrosine	29,37	neu	25,28	tyrosine	neu	CHEBI:18186	13866(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|END_ENTITY	Reciprocal regulation of neu tyrosine kinase activity and caveolin-1 protein expression in vitro and in vivo .
12223548	0	tyrosine	67,75	neurofascin	105,116	tyrosine	neurofascin	CHEBI:18186	23114	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	A new activity of doublecortin in recognition of the phospho-FIGQY tyrosine in the cytoplasmic domain of neurofascin .
23770246	0	tyrosine	108,116	neuroligin-1	136,148	tyrosine	neuroligin-1	CHEBI:18186	22871	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Neurexin-1b binding to neuroligin-1 triggers the preferential recruitment of PSD-95 versus gephyrin through tyrosine phosphorylation of neuroligin-1 .
5461618	0	tyrosine	44,52	neurophysin-II	71,85	tyrosine	neurophysin-II	CHEBI:18186	280728(Tax:9913)	Chemical	Gene	residue|amod|START_ENTITY residue|nmod|END_ENTITY	Studies on the chemical modification of the tyrosine residue in bovine neurophysin-II .
1375038	0	tyrosine	9,17	neurotrophin-4	51,65	tyrosine	neurotrophin-4	CHEBI:18186	100379108(Tax:8355)	Chemical	Gene	kinase|amod|START_ENTITY receptor|nsubj|kinase receptor|nmod|END_ENTITY	The trkB tyrosine protein kinase is a receptor for neurotrophin-4 .
1690564	0	tyrosine	14,22	nicotinic_acetylcholine_receptor	46,78	tyrosine	nicotinic acetylcholine receptor	CHEBI:18186	170945(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY Regulation|nmod|phosphorylation Regulation|nmod|END_ENTITY	Regulation of tyrosine phosphorylation of the nicotinic_acetylcholine_receptor at the rat neuromuscular junction .
16875784	0	tyrosine	29,37	nitric_oxide_synthase	66,87	tyrosine	nitric oxide synthase	CHEBI:18186	4843	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Sodium_orthovanadate induced tyrosine phosphorylation of platelet nitric_oxide_synthase negatively regulates enzyme activity .
11207269	0	tyrosine	86,94	nucleolin	125,134	tyrosine	nucleolin	CHEBI:18186	4691	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Activation of the EBV/C3d _ receptor -LRB- CR2 , CD21 -RRB- on human B lymphocyte surface triggers tyrosine phosphorylation of the 95-kDa nucleolin and its interaction with phosphatidylinositol 3 kinase .
16338221	0	tyrosine	27,35	occludin	55,63	tyrosine	occludin	CHEBI:18186	83497(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Cerebral_ischemia enhances tyrosine phosphorylation of occludin in brain capillaries .
19319148	0	tyrosine	37,45	occludin	65,73	tyrosine	occludin	CHEBI:18186	100506658	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Inhibition of Src activity decreases tyrosine phosphorylation of occludin in brain_capillaries and attenuates increase in permeability of the blood-brain barrier after transient focal cerebral_ischemia .
14600289	0	tyrosine	79,87	ornithine_decarboxylase	43,66	tyrosine	ornithine decarboxylase	CHEBI:18186	24609(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|changes changes|nmod|END_ENTITY	Hexachlorobenzene-induced early changes in ornithine_decarboxylase and protein tyrosine kinase activities , polyamines and c-Myc , c-Fos and c-Jun proto-oncogenes in rat liver .
8330345	0	tyrosine	81,89	ornithine_decarboxylase	56,79	tyrosine	ornithine decarboxylase	CHEBI:18186	24609(Tax:10116)	Chemical	Gene	kinase|amod|START_ENTITY kinase|amod|END_ENTITY	Modulating effect of amount and types of dietary fat on ornithine_decarboxylase , tyrosine protein kinase and prostaglandins production during colon_carcinogenesis in male F344 rats .
23843230	0	tyrosine	28,36	oviductin	8,17	tyrosine	oviductin	CHEBI:18186	5016	Chemical	Gene	phosphorylation|amod|START_ENTITY regulates|dobj|phosphorylation regulates|nsubj|END_ENTITY	Hamster oviductin regulates tyrosine phosphorylation of sperm proteins during in vitro capacitation .
14642088	0	tyrosine	11,19	p120	1,5	tyrosine	p120	CHEBI:18186	12388(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	-LSB- p120 -LRB- ctn -RRB- tyrosine phosphorylation are involved in the biologic behavior changes of hepatocellular_carcinoma cells -RSB- .
1851549	0	tyrosine	28,36	p120	56,60	tyrosine	p120	CHEBI:18186	12388(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	PDGF , CSF-1 , and EGF induce tyrosine phosphorylation of p120 , a pp60src transformation-associated substrate .
7514295	0	tyrosine	31,39	p120	59,63	tyrosine	p120	CHEBI:18186	1500	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Rapid T-cell receptor-mediated tyrosine phosphorylation of p120 , an Fyn/Lck Src homology 3 domain-binding protein .
1569084	0	tyrosine	53,61	p120GAP	45,52	tyrosine	p120GAP	CHEBI:18186	5921	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Erythropoietin induces p21ras activation and p120GAP tyrosine phosphorylation in human erythroleukemia cells .
8589330	0	tyrosine	24,32	p125	52,56	tyrosine	p125	CHEBI:18186	207352(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|kinase kinase|amod|END_ENTITY	Endothelin-1 stimulates tyrosine phosphorylation of p125 focal adhesion kinase in mesangial cells .
9756930	0	tyrosine	82,90	p125	132,136	tyrosine	p125	CHEBI:18186	11196	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Activation of human endothelial cells via S-endo-1 antigen -LRB- CD146 -RRB- stimulates the tyrosine phosphorylation of focal adhesion kinase p125 -LRB- FAK -RRB- .
10402223	0	tyrosine	22,30	p125FAK	50,57	tyrosine	p125FAK	CHEBI:18186	25614(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Endothelin stimulates tyrosine phosphorylation of p125FAK and p130Cas in rat cerebral cortex .
12651850	0	tyrosine	21,29	p125FAK	49,56	tyrosine	p125FAK	CHEBI:18186	25614(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Phosphospecific site tyrosine phosphorylation of p125FAK and proline-rich kinase 2 is differentially regulated by cholecystokinin receptor type A activation in pancreatic acini .
1329743	0	tyrosine	69,77	p125FAK	126,133	tyrosine	p125FAK	CHEBI:18186	5747	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Activation of transforming G protein-coupled receptors induces rapid tyrosine phosphorylation of cellular proteins , including p125FAK and the p130 v-src substrate .
23117335	0	tyrosine	32,40	p125FAK	60,67	tyrosine	p125FAK	CHEBI:18186	5747	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Effect of tumor gangliosides on tyrosine phosphorylation of p125FAK in platelet adhesion to collagen .
7525357	0	tyrosine	34,42	p125FAK	62,69	tyrosine	p125FAK	CHEBI:18186	14083(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Botulinum C3 exoenzyme blocks the tyrosine phosphorylation of p125FAK and paxillin induced by bombesin and endothelin .
7525558	0	tyrosine	41,49	p125FAK	20,27	tyrosine	p125FAK	CHEBI:18186	14083(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Sphingosine induces p125FAK and paxillin tyrosine phosphorylation , actin stress fiber formation , and focal contact assembly in Swiss_3T3 cells .
7589239	0	tyrosine	8,16	p125FAK	0,7	tyrosine	p125FAK	CHEBI:18186	5747	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	p125FAK tyrosine phosphorylation and focal adhesion assembly : studies with phosphotyrosine phosphatase inhibitors .
7592646	0	tyrosine	44,52	p125FAK	72,79	tyrosine	p125FAK	CHEBI:18186	14083(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Sphingosylphosphorylcholine rapidly induces tyrosine phosphorylation of p125FAK and paxillin , rearrangement of the actin cytoskeleton and focal contact assembly .
7896849	0	tyrosine	47,55	p125FAK	75,82	tyrosine	p125FAK	CHEBI:18186	14083(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Guanosine_5 ' -3 - O - -LRB- thio -RRB- triphosphate stimulates tyrosine phosphorylation of p125FAK and paxillin in permeabilized Swiss_3T3 cells .
8550600	0	tyrosine	99,107	p125FAK	78,85	tyrosine	p125FAK	CHEBI:18186	14083(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Pasteurella_multocida toxin , a potent intracellularly acting mitogen , induces p125FAK and paxillin tyrosine phosphorylation , actin stress fiber formation , and focal contact assembly in Swiss_3T3 cells .
8649836	0	tyrosine	100,108	p125FAK	128,135	tyrosine	p125FAK	CHEBI:18186	25614(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	The bombesin/GRP receptor transfected into Rat-1 fibroblasts couples to phospholipase C activation , tyrosine phosphorylation of p125FAK and paxillin and cell proliferation .
9064347	0	tyrosine	15,23	p125FAK	60,67	tyrosine	p125FAK	CHEBI:18186	14083(Tax:10090)	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	RANTES induces tyrosine kinase activity of stably complexed p125FAK and ZAP-70 in human T cells .
9359417	0	tyrosine	27,35	p125FAK	55,62	tyrosine	p125FAK	CHEBI:18186	25614(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Cholecystokinin-stimulated tyrosine phosphorylation of p125FAK and paxillin is mediated by phospholipase C-dependent and - independent mechanisms and requires the integrity of the actin cytoskeleton and participation of p21rho .
9405068	0	tyrosine	40,48	p125FAK	68,75	tyrosine	p125FAK	CHEBI:18186	25614(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Neuromedin_B_receptor activation causes tyrosine phosphorylation of p125FAK by a phospholipase C independent mechanism which requires p21rho and integrity of the actin cytoskeleton .
9708406	0	tyrosine	18,26	p125FAK	46,53	tyrosine	p125FAK	CHEBI:18186	25614(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells .
8314789	0	tyrosine	51,59	p125_focal_adhesion_kinase	24,50	tyrosine	p125 focal adhesion kinase	CHEBI:18186	14083(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Bombesin stimulation of p125_focal_adhesion_kinase tyrosine phosphorylation .
8970151	0	tyrosine	92,100	p125_focal_adhesion_kinase	65,91	tyrosine	p125 focal adhesion kinase	CHEBI:18186	14083(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Dissociation of mitogen-activated protein kinase activation from p125_focal_adhesion_kinase tyrosine phosphorylation in Swiss_3T3 cells stimulated by bombesin , lysophosphatidic_acid , and platelet-derived growth factor .
10480886	0	tyrosine	38,46	p130	28,32	tyrosine	p130	CHEBI:18186	9221	Chemical	Gene	START_ENTITY|nsubj|stimulation stimulation|nmod|END_ENTITY	Shear stress stimulation of p130 -LRB- cas -RRB- tyrosine phosphorylation requires calcium-dependent c-Src activation .
11399057	0	tyrosine	160,168	p130	188,192	tyrosine	p130	CHEBI:18186	70769(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Y-27632 , an inhibitor of Rho-associated kinases , prevents tyrosine phosphorylation of focal_adhesion_kinase and paxillin induced by bombesin : dissociation from tyrosine phosphorylation of p130 -LRB- CAS -RRB- .
9188452	0	tyrosine	42,50	p130	32,36	tyrosine	p130	CHEBI:18186	9221	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of integrin-mediated p130 -LRB- Cas -RRB- tyrosine phosphorylation in human B cells .
9538253	0	tyrosine	23,31	p130	51,55	tyrosine	p130	CHEBI:18186	81758(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Depolarization-induced tyrosine phosphorylation of p130 -LRB- cas -RRB- .
9748296	0	tyrosine	40,48	p130	68,72	tyrosine	p130	CHEBI:18186	70769(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Insulin-like growth factor I stimulates tyrosine phosphorylation of p130 -LRB- Cas -RRB- , focal adhesion kinase , and paxillin .
9792114	0	tyrosine	31,39	p130	59,63	tyrosine	p130	CHEBI:18186	9221	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Shape change is independent of tyrosine phosphorylation of p130 in human platelets .
12832404	0	tyrosine	20,28	p130Cas	0,7	tyrosine	p130Cas	CHEBI:18186	9564	Chemical	Gene	Bmx/Etk|amod|START_ENTITY Couples|dobj|Bmx/Etk Couples|nsubj|END_ENTITY	p130Cas Couples the tyrosine kinase Bmx/Etk with regulation of the actin cytoskeleton and cell migration .
21245381	0	tyrosine	39,47	p130Cas	31,38	tyrosine	p130Cas	CHEBI:18186	9564	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells .
22710723	0	tyrosine	84,92	p130Cas	50,57	tyrosine	p130Cas	CHEBI:18186	9564	Chemical	Gene	START_ENTITY|nsubj|characterization characterization|nmod|END_ENTITY	Identification and functional characterization of p130Cas as a substrate of protein tyrosine phosphatase nonreceptor 14 .
7479864	0	tyrosine	61,69	p130Cas	87,94	tyrosine	p130Cas	CHEBI:18186	12927(Tax:10090)	Chemical	Gene	Interaction|nmod|START_ENTITY kinase|nsubj|Interaction kinase|dobj|END_ENTITY	Interaction between focal_adhesion_kinase and Crk-associated tyrosine kinase substrate p130Cas .
7541040	0	tyrosine	41,49	p130Cas	69,76	tyrosine	p130Cas	CHEBI:18186	12927(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Integrin-mediated cell adhesion promotes tyrosine phosphorylation of p130Cas , a Src homology 3-containing molecule having multiple Src homology 2-binding motifs .
9136985	0	tyrosine	54,62	p130Cas	82,89	tyrosine	p130Cas	CHEBI:18186	12927(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Characterization of the kinase activity essential for tyrosine phosphorylation of p130Cas in fibroblasts .
9171345	0	tyrosine	45,53	p130Cas	73,80	tyrosine	p130Cas	CHEBI:18186	9564	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	The PTPase YopH inhibits uptake of Yersinia , tyrosine phosphorylation of p130Cas and FAK , and the associated accumulation of these proteins in peripheral focal adhesions .
9184219	0	tyrosine	87,95	p130Cas	18,25	tyrosine	p130Cas	CHEBI:18186	9564	Chemical	Gene	phosphatase|compound|START_ENTITY YopH|appos|phosphatase substrate|nmod|YopH END_ENTITY|nmod|substrate	Identification of p130Cas as a substrate of Yersinia YopH -LRB- Yop51 -RRB- , a bacterial protein tyrosine phosphatase that translocates into mammalian cells and targets focal adhesions .
9325334	0	tyrosine	34,42	p130Cas	62,69	tyrosine	p130Cas	CHEBI:18186	9564	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Epidermal growth factor modulates tyrosine phosphorylation of p130Cas .
9927060	6	tyrosine	1172,1180	p130Cas	1265,1272	tyrosine	p130Cas	CHEBI:18186	9564	Chemical	Gene	levels|amod|START_ENTITY increased|dobj|levels increased|parataxis|rescue rescue|advcl|reverse reverse|nsubj|END_ENTITY	Overexpression of p130Cas increased total tyrosine phosphorylation levels of p130Cas without affecting those of FAK ; however , although p130Cas could reverse PTEN inhibition of cell invasion and migration , it did not rescue cell growth in U87MG cells .
10401986	0	tyrosine	41,49	p130cas	0,7	tyrosine	p130cas	CHEBI:18186	9564	Chemical	Gene	nitration|amod|START_ENTITY protein|nmod|nitration protein|nsubj|END_ENTITY	p130cas is a cellular target protein for tyrosine nitration induced by peroxynitrite .
12935502	0	tyrosine	104,112	p130cas	132,139	tyrosine	p130cas	CHEBI:18186	25414(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Possible involvement of calcineurin , protein kinase C , and Src-family kinases in angiotensin_II-induced tyrosine phosphorylation of p130cas in rat cardiac muscle .
8631823	0	tyrosine	124,132	p130cas	152,159	tyrosine	p130cas	CHEBI:18186	12927(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Adhesion through the interaction of lymphocyte_function-associated_antigen-1 with intracellular_adhesion_molecule-1 induces tyrosine phosphorylation of p130cas and its association with c-CrkII .
9285683	0	tyrosine	85,93	p130cas	47,54	tyrosine	p130cas	CHEBI:18186	9564	Chemical	Gene	recognition|amod|START_ENTITY mechanism|nmod|recognition Association|dep|mechanism Association|nmod|PTP-PEST PTP-PEST|nmod|domain domain|nmod|END_ENTITY	Association of PTP-PEST with the SH3 domain of p130cas ; a novel mechanism of protein tyrosine phosphatase substrate recognition .
9442079	0	tyrosine	27,35	p130cas	55,62	tyrosine	p130cas	CHEBI:18186	9564	Chemical	Gene	START_ENTITY|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Protein_kinase_C-dependent tyrosine phosphorylation of p130cas in differentiating neuroblastoma cells .
9729467	0	tyrosine	23,31	p130cas	158,165	tyrosine	p130cas	CHEBI:18186	25414(Tax:10116)	Chemical	Gene	dephosphorylation|amod|START_ENTITY stimulates|dobj|dephosphorylation stimulates|advcl|promoting promoting|nmod|END_ENTITY	Insulin stimulates the tyrosine dephosphorylation of docking protein p130cas -LRB- Crk-associated_substrate -RRB- , promoting the switch of the adaptor protein crk from p130cas to newly phosphorylated insulin receptor substrate-1 .
9729467	0	tyrosine	23,31	p130cas	69,76	tyrosine	p130cas	CHEBI:18186	25414(Tax:10116)	Chemical	Gene	dephosphorylation|amod|START_ENTITY dephosphorylation|nmod|END_ENTITY	Insulin stimulates the tyrosine dephosphorylation of docking protein p130cas -LRB- Crk-associated_substrate -RRB- , promoting the switch of the adaptor protein crk from p130cas to newly phosphorylated insulin receptor substrate-1 .
7530581	0	tyrosine	10,18	p140trkA	38,46	tyrosine	p140trkA	CHEBI:18186	59109(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Sustained tyrosine phosphorylation of p140trkA in PC12h-R cells responding rapidly to NGF .
7910395	5	tyrosine	440,448	p185	431,435	tyrosine	p185	CHEBI:18186	8661	Chemical	Gene	kinase|amod|START_ENTITY activity|amod|kinase has|dobj|activity has|nsubj|component component|nmod|END_ENTITY	The intracellular component of p185 has tyrosine kinase activity ; the extracellular domain has a structure resembling a growth factor receptor .
7927925	0	tyrosine	4,12	p185	59,63	tyrosine	p185	CHEBI:18186	8661	Chemical	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	The tyrosine kinase activity of the C-erbB-2 gene product -LRB- p185 -RRB- is required for growth inhibition by anti-p185 antibodies but not for the cytotoxicity of an anti-p185-ricin-A chain immunotoxin .
9585252	0	tyrosine	15,23	p185	43,47	tyrosine	p185	CHEBI:18186	8661	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Involvement of tyrosine phosphorylation of p185 -LRB- c-erbB2 / neu -RRB- in tumorigenicity induced by X-rays and the neu oncogene in human breast epithelial cells .
9087165	0	tyrosine	38,46	p185erbB2	28,37	tyrosine	p185erbB2	CHEBI:18186	2064	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Expression of the activated p185erbB2 tyrosine kinase in human epithelial cells leads to MAP kinase activation but does not confer oncogenicity .
3261240	0	tyrosine	15,23	p185neu	43,50	tyrosine	p185neu	CHEBI:18186	24337(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	EGF-stimulated tyrosine phosphorylation of p185neu : a potential model for receptor interactions .
7945309	0	tyrosine	32,40	p185neu	24,31	tyrosine	p185neu	CHEBI:18186	24337(Tax:10116)	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Nuclear localization of p185neu tyrosine kinase and its association with transcriptional transactivation .
7629101	0	tyrosine	78,86	p190	102,106	tyrosine	p190	CHEBI:18186	8506	Chemical	Gene	START_ENTITY|dobj|protein protein|amod|END_ENTITY	Two SH2 domains of p120 Ras GTPase-activating protein bind synergistically to tyrosine phosphorylated p190 Rho GTPase-activating protein .
15084284	0	tyrosine	92,100	p190RhoGAP	33,43	tyrosine	p190RhoGAP	CHEBI:18186	232906(Tax:10090)	Chemical	Gene	brain|nmod|START_ENTITY END_ENTITY|nmod|brain	Adhesion-dependent regulation of p190RhoGAP in the developing brain by the Abl-related gene tyrosine kinase .
10233380	0	tyrosine	158,166	p210	153,157	tyrosine	p210	CHEBI:18186	2125	Chemical	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Leucocyte alkaline phosphatase identifies terminally differentiated normal neutrophils and its lack in chronic_myelogenous_leukaemia is not dependent on p210 tyrosine kinase activity .
10779439	0	tyrosine	135,143	p210	122,126	tyrosine	p210	CHEBI:18186	14027(Tax:10090)	Chemical	Gene	kinases|compound|START_ENTITY kinases|amod|END_ENTITY	Analysis of the biologic properties of p230 Bcr-Abl reveals unique and overlapping properties with the oncogenic p185 and p210 Bcr-Abl tyrosine kinases .
14654084	0	tyrosine	100,108	p210	87,91	tyrosine	p210	CHEBI:18186	14027(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Endoplasmic reticulum stress initiates apoptotic death induced by STI571 inhibition of p210 bcr-abl tyrosine kinase .
15048068	0	tyrosine	99,107	p210	86,90	tyrosine	p210	CHEBI:18186	14027(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Chk2 drives late G1/early S phase arrest of clonal myeloid progenitors expressing the p210 BCR-ABL tyrosine kinase in response to STI571 .
8637231	6	tyrosine	2374,2382	p210	2359,2363	tyrosine	p210	CHEBI:18186	2125	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	It is provocative that at least seven proteins rapidly and transiently phosphorylated on tyrosine in the c-kit_ligand signal transduction pathway in lin - normal blasts may be constitutive substrates for the p210 activated tyrosine kinase in comparable lin - chronic phase CML blasts .
21715330	0	tyrosine	77,85	p27	115,118	tyrosine	p27	CHEBI:18186	3429	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|protein protein|amod|END_ENTITY	Incomplete folding upon binding mediates Cdk4/cyclin D complex activation by tyrosine phosphorylation of inhibitor p27 protein .
1551112	0	tyrosine	49,57	p34cdc2	41,48	tyrosine	p34cdc2	CHEBI:18186	983	Chemical	Gene	dephosphorylation|compound|START_ENTITY dephosphorylation|amod|END_ENTITY	Inhibition of p34cdc2 kinase activation , p34cdc2 tyrosine dephosphorylation , and mitotic progression in Chinese_hamster ovary cells exposed to etoposide .
1709096	0	tyrosine	29,37	p34cdc2	17,24	tyrosine	p34cdc2	CHEBI:18186	379785(Tax:8355)	Chemical	Gene	phosphorylation|amod|START_ENTITY END_ENTITY|nmod|phosphorylation	Cyclin B targets p34cdc2 for tyrosine phosphorylation .
1850698	0	tyrosine	20,28	p34cdc2	48,55	tyrosine	p34cdc2	CHEBI:18186	983	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Cyclin promotes the tyrosine phosphorylation of p34cdc2 in a wee1 + dependent manner .
2005892	0	tyrosine	11,19	p34cdc2	39,46	tyrosine	p34cdc2	CHEBI:18186	379785(Tax:8355)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Cell cycle tyrosine phosphorylation of p34cdc2 and a microtubule-associated protein kinase homolog in Xenopus oocytes and eggs .
7530044	0	tyrosine	44,52	p34cdc2	72,79	tyrosine	p34cdc2	CHEBI:18186	983	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	1-beta-D-arabinofuranosylcytosine activates tyrosine phosphorylation of p34cdc2 and its association with the Src-like p56/p53lyn kinase in human myeloid_leukemia cells .
8137239	0	tyrosine	33,41	p34cdc2	61,68	tyrosine	p34cdc2	CHEBI:18186	983	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Ionizing radiation induces rapid tyrosine phosphorylation of p34cdc2 .
8705993	0	tyrosine	100,108	p34cdc2	121,128	tyrosine	p34cdc2	CHEBI:18186	983	Chemical	Gene	kinase|compound|START_ENTITY kinase|nmod|END_ENTITY	Nuclear signaling induced by ionizing radiation involves colocalization of the activated p56/p53lyn tyrosine kinase with p34cdc2 .
9288185	0	tyrosine	10,18	p34cdc2	38,45	tyrosine	p34cdc2	CHEBI:18186	983	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Transient tyrosine phosphorylation of p34cdc2 is an early event in radiation-induced apoptosis of prostate_cancer cells .
9407133	1	tyrosine	122,130	p34cdc2	150,157	tyrosine	p34cdc2	CHEBI:18186	983	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	The role of MCM2 and initiation of DNA replication to allow tyrosine phosphorylation of p34cdc2 .
8551221	0	tyrosine	63,71	p36	59,62	tyrosine	p36	CHEBI:18186	302	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	CD16-mediated p21ras activation is associated with Shc and p36 tyrosine phosphorylation and their binding with Grb2 in human natural killer cells .
11094059	0	tyrosine	28,36	p38	95,98	tyrosine	p38	CHEBI:18186	26416(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|caveolin-1 caveolin-1|nmod|activation activation|nmod|protein protein|amod|END_ENTITY	Cellular stress induces the tyrosine phosphorylation of caveolin-1 -LRB- Tyr -LRB- 14 -RRB- -RRB- via activation of p38 mitogen-activated protein kinase and c-Src_kinase .
14514016	0	tyrosine	4,12	p38	51,54	tyrosine	p38	CHEBI:18186	26416(Tax:10090)	Chemical	Gene	SHP2|amod|START_ENTITY modulates|nsubj|SHP2 modulates|dobj|END_ENTITY	The tyrosine phosphatase SHP2 modulates MAP kinase p38 and caspase_1 and 3 to foster neuronal survival .
15735648	0	tyrosine	72,80	p38	12,15	tyrosine	p38	CHEBI:18186	1432	Chemical	Gene	kinases|amod|START_ENTITY mediated|nmod|kinases mediated|nsubj|activation activation|amod|END_ENTITY	Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases .
16569674	4	tyrosine	745,753	p38	684,687	tyrosine	PKD	CHEBI:18186	18760(Tax:10090)	Chemical	Gene	kinase|amod|START_ENTITY PKB|dep|kinase PKB|appos|END_ENTITY	Unexpectedly , we did not reveal any difference in antigen-induced activation of many central signaling molecules -LRB- PKB , mitogen-activated protein kinase , p38 , Jun-N-terminal kinase , phospholipase C-gamma1 , Bruton 's tyrosine kinase , PKD , Fos and PKC-delta -RRB- in time-course as well as dose-response studies between PKC-epsilon-deficient and wild-type MCs .
17893873	0	tyrosine	46,54	p38	16,19	tyrosine	p38	CHEBI:18186	1432	Chemical	Gene	activity|amod|START_ENTITY MAPK|nmod|activity MAPK|amod|END_ENTITY	c-Abl activates p38 MAPK independently of its tyrosine kinase activity : Implications in cisplatin-based therapy .
18025155	0	tyrosine	4,12	p38	97,100	tyrosine	p38	CHEBI:18186	1432	Chemical	Gene	kinase|compound|START_ENTITY regulates|nsubj|kinase regulates|dobj|production production|nmod|macrophages macrophages|nmod|MAPK MAPK|amod|END_ENTITY	Bmx tyrosine kinase regulates TLR4-induced IL-6 production in human macrophages independently of p38 MAPK and NFkapp -RCB- B activity .
18954908	0	tyrosine	89,97	p38	119,122	tyrosine	p38	CHEBI:18186	1432	Chemical	Gene	kinase|amod|START_ENTITY kinase|appos|Pyk2 Pyk2|nmod|pathway pathway|amod|END_ENTITY	LPS-induced MCP-1 expression in human microvascular endothelial cells is mediated by the tyrosine kinase , Pyk2 via the p38 MAPK/NF-kappaB-dependent pathway .
19435873	0	tyrosine	31,39	p38	138,141	tyrosine	p38	CHEBI:18186	1432	Chemical	Gene	kinase|compound|START_ENTITY Inhibition|nmod|kinase enhances|nsubj|Inhibition enhances|nmod|activation activation|nmod|pathway pathway|amod|END_ENTITY	Inhibition of the met receptor tyrosine kinase signaling enhances the chemosensitivity of glioma cell lines to CDDP through activation of p38 MAPK pathway .
23024367	0	tyrosine	4,12	p38	77,80	tyrosine	p38	CHEBI:18186	1432	Chemical	Gene	c-Met|amod|START_ENTITY contributes|nsubj|c-Met contributes|nmod|function function|nmod|kinase kinase|amod|END_ENTITY	The tyrosine kinase c-Met contributes to the pro-tumorigenic function of the p38 kinase in human bile duct cholangiocarcinoma cells .
23178573	0	tyrosine	83,91	p38	0,3	tyrosine	p38	CHEBI:18186	1432	Chemical	Gene	phosphorylation|amod|START_ENTITY promoting|dobj|phosphorylation enhances|advcl|promoting enhances|nsubj|kinase kinase|nummod|END_ENTITY	p38 MAP kinase enhances EGF-induced apoptosis in A431 carcinoma cells by promoting tyrosine phosphorylation of STAT1 .
23236157	0	tyrosine	12,20	p38	82,85	tyrosine	p38	CHEBI:18186	26416(Tax:10090)	Chemical	Gene	Shp2|amod|START_ENTITY promotes|nsubj|Shp2 promotes|nmod|inhibition inhibition|nmod|kinase kinase|amod|END_ENTITY	Nonreceptor tyrosine phosphatase Shp2 promotes adipogenesis through inhibition of p38 MAP kinase .
27068033	8	tyrosine	1365,1373	p38	1337,1340	tyrosine	JNK	D014443	116554(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY regulate|dobj|phosphorylation regulate|nsubj|MAPKs MAPKs|appos|END_ENTITY	MAPKs -LRB- p38 and JNK -RRB- could regulate tyrosine STAT3 phosphorylation , which suggested that the JAK2/STAT3 pathway might be the downstream of p38/JNK MAPK pathways .
7535770	0	tyrosine	133,141	p38	58,61	tyrosine	p38	CHEBI:18186	1432	Chemical	Gene	phosphorylation|nmod|START_ENTITY activation|nmod|phosphorylation kinase|acl|activation kinase|amod|END_ENTITY	Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine .
7914033	2	tyrosine	244,252	p38	230,233	tyrosine	p38	CHEBI:18186	1432	Chemical	Gene	phosphorylated|advmod|START_ENTITY kinase|acl:relcl|phosphorylated kinase|appos|END_ENTITY	A protein kinase , p38 , that was tyrosine phosphorylated in response to LPS , was cloned .
9596671	0	tyrosine	163,171	p38	105,108	tyrosine	p38	CHEBI:18186	1432	Chemical	Gene	p56Lck|amod|START_ENTITY implication|nmod|p56Lck activation|dep|implication activation|amod|END_ENTITY	T-Cell receptor signaling pathway exerts a negative control on thrombin-mediated increase in -LSB- Ca2 + -RSB- i and p38 MAPK activation in Jurkat T cells : implication of the tyrosine kinase p56Lck .
9603971	4	tyrosine	709,717	p38	742,745	tyrosine	p38	CHEBI:18186	1432	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|kinase kinase|amod|END_ENTITY	High glucose treatment activated the tyrosine phosphorylation of both p38 kinase and JNK in a dose - and time-dependent fashion .
23932588	0	tyrosine	85,93	p38a	31,35	tyrosine	p38a	CHEBI:18186	1432	Chemical	Gene	phosphatases|compound|START_ENTITY phosphatases|amod|END_ENTITY	The differential regulation of p38a by the neuronal kinase interaction motif protein tyrosine phosphatases , a detailed molecular study .
2452172	0	tyrosine	65,73	p42	93,96	tyrosine	p42	CHEBI:18186	105278(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Protein kinase C mediates platelet-derived growth factor-induced tyrosine phosphorylation of p42 .
7561108	0	tyrosine	34,42	p44	96,99	tyrosine	p44	CHEBI:18186	10561	Chemical	Gene	phosphorylation|amod|START_ENTITY kinases|nsubj|phosphorylation kinases|dobj|END_ENTITY	Lipopolysaccharide stimulates the tyrosine phosphorylation of mitogen-activated protein kinases p44 , p42 , and p41 in vascular endothelial cells in a soluble CD14-dependent manner .
15774483	0	tyrosine	13,21	p47phox	41,48	tyrosine	p47phox	CHEBI:18186	653361	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Src-mediated tyrosine phosphorylation of p47phox in hyperoxia-induced activation of NADPH oxidase and generation of reactive oxygen species in lung endothelial cells .
1639064	0	tyrosine	17,25	p50csk	10,16	tyrosine	p50csk	CHEBI:18186	1445	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	The human p50csk tyrosine kinase phosphorylates p56lck at Tyr-505 and down regulates its catalytic activity .
8522345	0	tyrosine	96,104	p50csk	81,87	tyrosine	p50csk	CHEBI:18186	1445	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Production and characterization of monoclonal antibodies against the recombinant p50csk protein tyrosine kinase : a tool for signal transduction research .
21544459	0	tyrosine	36,44	p53	84,87	tyrosine	p53	CHEBI:18186	101833915	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Stilbene estrogen-mediated enhanced tyrosine phosphorylation of the nuclear protein p53 by nuclear matrix associated tyrosine kinase -LRB- s -RRB- .
10087161	0	tyrosine	23,31	p56	14,17	tyrosine	p56	CHEBI:18186	8999	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of p56 -LRB- lck -RRB- tyrosine kinase by isothiazolones .
10190908	0	tyrosine	24,32	p56	141,144	tyrosine	p56	CHEBI:18186	8999	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|receptor receptor|acl|signaling signaling|dobj|motifs motifs|acl:relcl|thymocytes thymocytes|advcl|limiting limiting|dobj|END_ENTITY	ZAP-70 protein promotes tyrosine phosphorylation of T cell receptor signaling motifs -LRB- ITAMs -RRB- in immature CD4 -LRB- + -RRB- 8 -LRB- + -RRB- thymocytes with limiting p56 -LRB- lck -RRB- .
10458749	0	tyrosine	9,17	p56	168,171	tyrosine	p56	CHEBI:18186	15957(Tax:10090)	Chemical	Gene	phosphatase|compound|START_ENTITY regulates|nsubj|phosphatase regulates|parataxis|function function|nmod|END_ENTITY	The CD45 tyrosine phosphatase regulates CD3-induced signal transduction and T cell development in recombinase-deficient mice : restoration of pre-TCR function by active p56 -LRB- lck -RRB- .
11533187	0	tyrosine	27,35	p56	18,21	tyrosine	p56	CHEBI:18186	8999	Chemical	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	Downregulation of p56 -LRB- lck -RRB- tyrosine kinase activity in T cells of squirrel monkeys -LRB- Saimiri_sciureus -RRB- correlates with the nontransforming and apathogenic properties of herpesvirus_saimiri in its natural host .
19325836	0	tyrosine	31,39	p56	14,17	tyrosine	p56	CHEBI:18186	8999	Chemical	Gene	START_ENTITY|nsubj|study study|nmod|protein protein|compound|END_ENTITY	QSAR study of p56 -LRB- lck -RRB- protein tyrosine kinase inhibitory activity of flavonoid derivatives using MLR and GA-PLS .
25139491	0	tyrosine	86,94	p56	77,80	tyrosine	p56	CHEBI:18186	8999	Chemical	Gene	kinase|amod|START_ENTITY END_ENTITY|amod|kinase	Damnacanthal inhibits the NF-kB/RIP -2 / caspase-1 signal pathway by inhibiting p56 -LRB- lck -RRB- tyrosine kinase .
2997208	0	tyrosine	76,84	p56	110,113	tyrosine	p56	CHEBI:18186	15957(Tax:10090)	Chemical	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Vesicular_stomatitis virus produced from infected LSTRA_lymphoma cells bear tyrosine protein kinase activity -LRB- p56 -RRB- .
9645606	0	tyrosine	25,33	p56	16,19	tyrosine	p56	CHEBI:18186	15957(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Requirement Requirement|nmod|END_ENTITY	Requirement for p56 -LRB- lck -RRB- tyrosine kinase activation in Th subset differentiation .
17932036	0	tyrosine	7,15	p56Lck	0,6	tyrosine	p56Lck	CHEBI:18186	16818(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	p56Lck tyrosine kinase enhances the assembly of death-inducing signaling complex during Fas-mediated apoptosis .
11231305	1	tyrosine	104,112	p56_LCK	77,84	tyrosine	p56 LCK	CHEBI:18186	3932	Chemical	Gene	kinases|amod|START_ENTITY kinases|amod|END_ENTITY	Requirement for p56_LCK and ZAP-70 protein tyrosine kinases .
8607833	0	tyrosine	97,105	p56_lck	77,84	tyrosine	p56 lck	CHEBI:18186	3932	Chemical	Gene	kinases|compound|START_ENTITY kinases|amod|END_ENTITY	Differences in binding of PI 3-kinase to the src-homology domains 2 and 3 of p56_lck and p59_fyn tyrosine kinases .
11694532	0	tyrosine	109,117	p56lck	102,108	tyrosine	p56lck	CHEBI:18186	3932	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Differential association of CD45 isoforms with CD4 and CD8 regulates the actions of specific pools of p56lck tyrosine kinase in T_cell_antigen_receptor signal transduction .
12100025	0	tyrosine	188,196	p56lck	181,187	tyrosine	p56lck	CHEBI:18186	3932	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Anti-CD45 isoform antibodies enhance phagocytosis and gene expression of IL-8 and TNF-alpha in human neutrophils by differential suppression on protein tyrosine phosphorylation and p56lck tyrosine kinase .
12823281	0	tyrosine	71,79	p56lck	56,62	tyrosine	p56lck	CHEBI:18186	3932	Chemical	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	HIV-1_infection is facilitated in T cells by decreasing p56lck protein tyrosine kinase activity .
1358625	0	tyrosine	60,68	p56lck	88,94	tyrosine	p56lck	CHEBI:18186	3932	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|dobj|activity activity|nmod|END_ENTITY	Both T cell receptor -LRB- TcR -RRB- - CD3 complex and CD2 increase the tyrosine kinase activity of p56lck .
15006144	0	tyrosine	92,100	p56lck	85,91	tyrosine	p56lck	CHEBI:18186	3932	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Utilization of microarrayed compound screening -LRB- microARCS -RRB- to identify inhibitors of p56lck tyrosine kinase .
15110947	0	tyrosine	89,97	p56lck	82,88	tyrosine	p56lck	CHEBI:18186	3932	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	A quantum mechanical study on phosphotyrosyl peptide binding to the SH2 domain of p56lck tyrosine kinase with insights into the biochemistry of intracellular signal transduction events .
1547820	0	tyrosine	145,153	p56lck	162,168	tyrosine	p56lck	CHEBI:18186	16818(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	Disruption of CD8-dependent negative and positive selection of thymocytes is correlated with a decreased association between CD8 and the protein tyrosine kinase , p56lck .
1678351	0	tyrosine	4,12	p56lck	32,38	tyrosine	p56lck	CHEBI:18186	3932	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	The tyrosine kinase activity of p56lck is increased in human T cells activated via CD2 .
1687313	0	tyrosine	72,80	p56lck	57,63	tyrosine	p56lck	CHEBI:18186	3932	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	The Raf-1 serine-threonine kinase is a substrate for the p56lck protein tyrosine kinase in human T-cells .
2109184	0	tyrosine	125,133	p56lck	118,124	tyrosine	p56lck	CHEBI:18186	3932	Chemical	Gene	kinase|amod|START_ENTITY kinase|amod|END_ENTITY	Short related sequences in the cytoplasmic domains of CD4 and CD8 mediate binding to the amino-terminal domain of the p56lck tyrosine protein kinase .
3380789	0	tyrosine	74,82	p56lck	99,105	tyrosine	p56lck	CHEBI:18186	3932	Chemical	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	Mutation of a site of tyrosine phosphorylation in the lymphocyte-specific tyrosine protein kinase , p56lck , reveals its oncogenic potential in fibroblasts .
7507203	0	tyrosine	112,120	p56lck	105,111	tyrosine	p56lck	CHEBI:18186	3932	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Tyrosine phosphorylation of CD45 phosphotyrosine phosphatase by p50csk kinase creates a binding site for p56lck tyrosine kinase and activates the phosphatase .
7518561	0	tyrosine	75,83	p56lck	14,20	tyrosine	p56lck	CHEBI:18186	3932	Chemical	Gene	START_ENTITY|nsubj|Activation Activation|nmod|END_ENTITY	Activation of p56lck by p72syk through physical association and N-terminal tyrosine phosphorylation .
7682187	0	tyrosine	100,108	p56lck	85,91	tyrosine	p56lck	CHEBI:18186	3932	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Mouse monoclonal antibodies that specifically recognize an amino-terminal epitope of p56lck protein tyrosine kinase .
7826952	0	tyrosine	40,48	p56lck	33,39	tyrosine	p56lck	CHEBI:18186	3932	Chemical	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	p59fyn tyrosine kinase regulates p56lck tyrosine kinase activity and early TCR-mediated signaling .
7872793	0	tyrosine	59,67	p56lck	52,58	tyrosine	p56lck	CHEBI:18186	3932	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Dimerization of native and C-terminally proteolyzed p56lck tyrosine kinase .
7902564	0	tyrosine	132,140	p56lck	125,131	tyrosine	p56lck	CHEBI:18186	3932	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Decreased signaling competence as a result of receptor overexpression : overexpression of CD4 reduces its ability to activate p56lck tyrosine kinase and to regulate T-cell antigen receptor expression in immature CD4 + CD8 + thymocytes .
7910947	0	tyrosine	94,102	p56lck	87,93	tyrosine	p56lck	CHEBI:18186	3932	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Signal transduction of interleukin_2 in human natural killer cells : involvement of the p56lck tyrosine kinase .
8020561	0	tyrosine	100,108	p56lck	93,99	tyrosine	p56lck	CHEBI:18186	3932	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Activation of phosphatidylinositol-3-kinase in Jurkat T cells depends on the presence of the p56lck tyrosine kinase .
8207199	0	tyrosine	82,90	p56lck	75,81	tyrosine	p56lck	CHEBI:18186	3932	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	LFA-1-mediated antigen-independent T cell adhesion is regulated by CD4 and p56lck tyrosine kinase .
8228817	0	tyrosine	83,91	p56lck	76,82	tyrosine	p56lck	CHEBI:18186	16818(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Regulation of T cell receptor expression in immature CD4 + CD8 + thymocytes by p56lck tyrosine kinase : basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules .
8471045	0	tyrosine	131,139	p56lck	124,130	tyrosine	p56lck	CHEBI:18186	3932	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Haemin enhancement of glucose transport in human lymphocytes : stimulation of protein tyrosine phosphatase and activation of p56lck tyrosine kinase .
9064353	0	tyrosine	23,31	p56lck	16,22	tyrosine	p56lck	CHEBI:18186	16818(Tax:10090)	Chemical	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Requirement for p56lck tyrosine kinase activation in T cell receptor-mediated thymic selection .
9120273	0	tyrosine	69,77	p56lck	62,68	tyrosine	p56lck	CHEBI:18186	3932	Chemical	Gene	kinases|compound|START_ENTITY kinases|amod|END_ENTITY	MHC class I ligation of human T cells activates the ZAP70 and p56lck tyrosine kinases , leads to an alternative phenotype of the TCR/CD3 _ zeta-chain , and induces apoptosis .
9341123	0	tyrosine	79,87	p56lck	72,78	tyrosine	p56lck	CHEBI:18186	3932	Chemical	Gene	kinase|amod|START_ENTITY kinase|nummod|END_ENTITY	Human homologue of the Drosophila discs large tumor suppressor binds to p56lck tyrosine kinase and Shaker type Kv1 .3 potassium channel in T lymphocytes .
10930415	0	tyrosine	88,96	p59fyn	67,73	tyrosine	p59fyn	CHEBI:18186	527263(Tax:9913)	Chemical	Gene	kinase|compound|START_ENTITY END_ENTITY|appos|kinase	Regulation of the bovine kidney microsomal chloride channel p64 by p59fyn , a Src family tyrosine kinase .
3061807	0	tyrosine	66,74	p59fyn	39,45	tyrosine	p59fyn	CHEBI:18186	2534	Chemical	Gene	kinase|compound|START_ENTITY END_ENTITY|appos|kinase	Identification and characterization of p59fyn -LRB- a src-like protein tyrosine kinase -RRB- in normal and polyoma virus transformed cells .
8144681	0	tyrosine	31,39	p59fyn	24,30	tyrosine	p59fyn	CHEBI:18186	14360(Tax:10090)	Chemical	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	Oncogenic activation of p59fyn tyrosine protein kinase by mutation of its carboxyl-terminal site of tyrosine phosphorylation , tyrosine 528 .
8353285	0	tyrosine	155,163	p59fyn	148,154	tyrosine	p59fyn	CHEBI:18186	2534	Chemical	Gene	kinases|compound|START_ENTITY kinases|amod|END_ENTITY	Reactive oxygen intermediates activate NF-kappa_B in a tyrosine kinase-dependent mechanism and in combination with vanadate activate the p56lck and p59fyn tyrosine kinases in human lymphocytes .
8566014	0	tyrosine	142,150	p59fyn	127,133	tyrosine	p59fyn	CHEBI:18186	2534	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Human T lymphocyte activation induces tyrosine phosphorylation of alpha-tubulin and its association with the SH2 domain of the p59fyn protein tyrosine kinase .
9278304	0	tyrosine	108,116	p59fyn	101,107	tyrosine	p59fyn	CHEBI:18186	2534	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	CD28-induced cytokine production and proliferation by thymocytes are differentially regulated by the p59fyn tyrosine kinase .
9460655	0	tyrosine	18,26	p59fyn	46,52	tyrosine	p59fyn	CHEBI:18186	25150(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Prolactin induced tyrosine phosphorylation of p59fyn may mediate phosphatidylinositol 3-kinase activation in Nb2 cells .
8886793	0	tyrosine	112,120	p60SRC	105,111	tyrosine	p60SRC	CHEBI:18186	20779(Tax:10090)	Chemical	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Induction of c-jun protooncogene expression by hydrogen_peroxide through hydroxyl radical generation and p60SRC tyrosine kinase activation .
11119516	0	tyrosine	79,87	p60Src	96,102	tyrosine	p60Src	CHEBI:18186	6714	Chemical	Gene	kinases|compound|START_ENTITY kinases|amod|END_ENTITY	Invasion of human epithelial cells by Pseudomonas_aeruginosa involves src-like tyrosine kinases p60Src and p59Fyn .
10585470	0	tyrosine	29,37	p62	20,23	tyrosine	p62	CHEBI:18186	23636	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|END_ENTITY	SHP-1 regulation of p62 -LRB- DOK -RRB- tyrosine phosphorylation in macrophages .
7799925	0	tyrosine	91,99	p62	15,18	tyrosine	p62	CHEBI:18186	23636	Chemical	Gene	START_ENTITY|nsubj|Association Association|nmod|END_ENTITY	Association of p62 , a multifunctional SH2 - and SH3-domain-binding protein , with src family tyrosine kinases , Grb2 , and phospholipase_C_gamma-1 .
11551902	0	tyrosine	33,41	p62dok	26,32	tyrosine	p62dok	CHEBI:18186	1796	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Insulin_receptor-mediated p62dok tyrosine phosphorylation at residues 362 and 398 plays distinct roles for binding GTPase-activating protein and Nck and is essential for inhibiting insulin-stimulated_activation_of_Ras_and_Akt .
12870650	0	tyrosine	165,173	p65_NF-kappaB	193,206	tyrosine	p65 NF-kappaB	CHEBI:18186	19697(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Phosphoinositide 3-kinase activity leads to silica-induced NF-kappaB activation through interacting with tyrosine-phosphorylated I -LRB- kappa -RRB- B-alpha and contributing to tyrosine phosphorylation of p65_NF-kappaB .
8226994	0	tyrosine	218,226	p72_Syk	202,209	tyrosine	p72 Syk	CHEBI:18186	6850	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Cross-linking of Fc_gamma_receptor_I -LRB- Fc_gamma_RI -RRB- and receptor II -LRB- Fc_gamma_RII -RRB- on monocytic cells activates a signal transduction pathway common to both Fc receptors that involves the stimulation of p72_Syk protein tyrosine kinase .
7523143	0	tyrosine	62,70	p72syk	94,100	tyrosine	p72syk	CHEBI:18186	6850	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|kinase kinase|amod|END_ENTITY	Triggering of human natural killer cells through CD16 induces tyrosine phosphorylation of the p72syk kinase .
7796910	0	tyrosine	35,43	p72syk	20,26	tyrosine	p72syk	CHEBI:18186	25155(Tax:10116)	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Site specificity of p72syk protein tyrosine kinase : efficient phosphorylation of motifs recognized by Src homology 2 domains of the Src family .
8344947	0	tyrosine	7,15	p72syk	0,6	tyrosine	p72syk	CHEBI:18186	6850	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	p72syk tyrosine kinase is activated by oxidizing conditions that induce lymphocyte tyrosine phosphorylation and Ca2 + signals .
8611520	0	tyrosine	100,108	p72syk	69,75	tyrosine	p72syk	CHEBI:18186	6850	Chemical	Gene	kinases|compound|START_ENTITY kinases|amod|END_ENTITY	SH2 domains mediate the sequential phosphorylation of HS1 protein by p72syk and Src-related protein tyrosine kinases .
9029132	0	tyrosine	69,77	p72syk	62,68	tyrosine	p72syk	CHEBI:18186	6850	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Signaling by adhesion in human neutrophils : activation of the p72syk tyrosine kinase and formation of protein complexes containing p72syk and Src family kinases in neutrophils spreading over fibrinogen .
2106566	0	tyrosine	29,37	p75	71,74	tyrosine	p75	CHEBI:18186	3560	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Interleukin_2 -LRB- IL-2 -RRB- - induced tyrosine phosphorylation of IL-2_receptor p75 .
9368064	0	tyrosine	25,33	p75	55,58	tyrosine	p75	CHEBI:18186	7133	Chemical	Gene	dephosphorylation|amod|START_ENTITY dephosphorylation|nmod|END_ENTITY	Growth factors stimulate tyrosine dephosphorylation of p75 and its dissociation from the SH2 domain of Grb2 .
8119916	0	tyrosine	52,60	p93c-Fes	80,88	tyrosine	p93c-Fes	CHEBI:18186	2242	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	p210Bcr/Abl and p160v-Abl induce an increase in the tyrosine phosphorylation of p93c-Fes .
3162757	0	tyrosine	24,32	p93c-fes	15,23	tyrosine	p93c-fes	CHEBI:18186	2242	Chemical	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	Association of p93c-fes tyrosine protein kinase with granulocytic/monocytic differentiation and resistance to differentiating agents in HL-60 leukemia cells .
7664264	0	tyrosine	12,20	pRb	75,78	tyrosine	pRb	CHEBI:18186	5925	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|nmod|END_ENTITY	The nuclear tyrosine kinase Rak associates with the retinoblastoma protein pRb .
10554546	0	tyrosine	14,22	paxillin	42,50	tyrosine	paxillin	D014443	5829	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	-LSB- Differential tyrosine phosphorylation of paxillin in human corneal epithelial cells on extracellular matrix proteins -RSB- .
10571080	0	tyrosine	93,101	paxillin	123,131	tyrosine	paxillin	CHEBI:18186	360820(Tax:10116)	Chemical	Gene	dephosphorylation|amod|START_ENTITY dephosphorylation|nmod|END_ENTITY	Transformation of rat fibroblasts by phospholipase_C-gamma1 overexpression is accompanied by tyrosine dephosphorylation of paxillin .
10715396	0	tyrosine	13,21	paxillin	41,49	tyrosine	paxillin	CHEBI:18186	5829	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Differential tyrosine phosphorylation of paxillin in human corneal epithelial cells on extracellular matrix proteins Purpose : To understand the interaction of corneal epithelial cells with laminin , fibronectin , and collagen type IV , major components of basement membrane , we investigated whether tyrosine phosphorylation of paxillin was increased during attachment of these cells to matrix proteins .
10954702	0	tyrosine	95,103	paxillin	123,131	tyrosine	paxillin	CHEBI:18186	5829	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Integrin engagement , the actin cytoskeleton , and c-Src are required for the calcitonin-induced tyrosine phosphorylation of paxillin and HEF1 , but not for calcitonin-induced Erk1/2 phosphorylation .
11238916	0	tyrosine	52,60	paxillin	43,51	tyrosine	paxillin	CHEBI:18186	5829	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Protein_tyrosine_phosphatase phi regulates paxillin tyrosine phosphorylation and mediates colony-stimulating_factor_1-induced morphological changes in macrophages .
11287749	0	tyrosine	26,34	paxillin	54,62	tyrosine	paxillin	CHEBI:18186	5829	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Protein kinase C-mediated tyrosine phosphorylation of paxillin and focal_adhesion_kinase requires cytoskeletal integrity and is uncoupled to mitogen-activated protein kinase activation in human hepatoma cells .
12616494	0	tyrosine	28,36	paxillin	56,64	tyrosine	paxillin	CHEBI:18186	360820(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Toll-like receptor-mediated tyrosine phosphorylation of paxillin via MyD88-dependent and - independent pathways .
26697169	0	tyrosine	37,45	paxillin	15,23	tyrosine	paxillin	D014443	5829	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Role played by paxillin and paxillin tyrosine phosphorylation in hepatocyte_growth_factor / sphingosine-1-phosphate-mediated reactive oxygen species generation , lamellipodia formation , and endothelial barrier function .
7525604	0	tyrosine	88,96	paxillin	116,124	tyrosine	paxillin	CHEBI:18186	5829	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Complement receptor 3 -LRB- CR3 , Mac-1 , integrin alpha M beta_2 , CD11b/CD18 -RRB- is required for tyrosine phosphorylation of paxillin in adherent and nonadherent neutrophils .
7525608	0	tyrosine	26,34	paxillin	54,62	tyrosine	paxillin	CHEBI:18186	5829	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Beta_2 integrin-dependent tyrosine phosphorylation of paxillin in human neutrophils treated with tumor necrosis factor .
7537852	0	tyrosine	19,27	paxillin	47,55	tyrosine	paxillin	CHEBI:18186	5829	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	pp125FAK-dependent tyrosine phosphorylation of paxillin creates a high-affinity binding site for Crk .
7963537	0	tyrosine	58,66	paxillin	86,94	tyrosine	paxillin	CHEBI:18186	360820(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	The aggregation of the high affinity IgE receptor induces tyrosine phosphorylation of paxillin , a focal adhesion protein .
9024782	0	tyrosine	18,26	paxillin	65,73	tyrosine	paxillin	CHEBI:18186	395832(Tax:9031)	Chemical	Gene	START_ENTITY|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Integrin-mediated tyrosine phosphorylation and redistribution of paxillin during neuronal_adhesion .
9346905	1	tyrosine	124,132	paxillin	170,178	tyrosine	paxillin	CHEBI:18186	5829	Chemical	Gene	phosphorylation|amod|START_ENTITY effects|nmod|phosphorylation effects|nmod|END_ENTITY	Differential effects on tyrosine phosphorylation and association with paxillin .
9372922	0	tyrosine	184,192	paxillin	175,183	tyrosine	paxillin	CHEBI:18186	19303(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Inhibition of cell spreading by expression of the C-terminal domain of focal_adhesion_kinase -LRB- FAK -RRB- is rescued by coexpression of Src or catalytically inactive FAK : a role for paxillin tyrosine phosphorylation .
9548498	0	tyrosine	37,45	paxillin	65,73	tyrosine	paxillin	CHEBI:18186	5829	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Beta2 integrins are not required for tyrosine phosphorylation of paxillin in human neutrophils .
9870555	0	tyrosine	77,85	paxillin	56,64	tyrosine	paxillin	CHEBI:18186	5829	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Reactive oxygen species activate focal adhesion kinase , paxillin and p130cas tyrosine phosphorylation in endothelial cells .
15917086	0	tyrosine	24,32	phenylalanine_hydroxylase	94,119	tyrosine	phenylalanine hydroxylase	CHEBI:18186	5053	Chemical	Gene	START_ENTITY|dobj|binding binding|nmod|END_ENTITY	The active site residue tyrosine 325 influences iron binding and coupling efficiency in human phenylalanine_hydroxylase .
4265522	0	tyrosine	80,88	phenylalanine_hydroxylase	6,31	tyrosine	phenylalanine hydroxylase	CHEBI:18186	24616(Tax:10116)	Chemical	Gene	concentrations|nmod|START_ENTITY END_ENTITY|nmod|concentrations	Liver phenylalanine_hydroxylase activity in relation to blood concentrations of tyrosine and phenylalanine in the rat .
10417318	0	tyrosine	87,95	phogrin	42,49	tyrosine	phogrin	CHEBI:18186	5799	Chemical	Gene	homologue|compound|START_ENTITY granule|dobj|homologue granule|nsubj|phosphorylation phosphorylation|nmod|END_ENTITY	Secretagogue-dependent phosphorylation of phogrin , an insulin granule membrane protein tyrosine phosphatase homologue .
8772720	0	tyrosine	50,58	phogrin	85,92	tyrosine	phogrin	CHEBI:18186	5799	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase-like protein -LRB- phogrin -RRB- related to IA-2 .
8878534	0	tyrosine	74,82	phogrin	106,113	tyrosine	phogrin	CHEBI:18186	5799	Chemical	Gene	START_ENTITY|dobj|homologue homologue|appos|END_ENTITY	Molecular cloning and characterization of the human transmembrane protein tyrosine phosphatase homologue , phogrin , an autoantigen of type 1 diabetes .
12856723	0	tyrosine	41,49	phosphatase-2A	8,22	tyrosine	phosphatase-2A	CHEBI:18186	5524	Chemical	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Protein phosphatase-2A regulates protein tyrosine phosphatase activity in Lewis_lung_carcinoma tumor variants .
10814835	0	tyrosine	26,34	phosphatase_of_regenerating_liver_1	48,83	tyrosine	phosphatase of regenerating liver 1	CHEBI:18186	7803	Chemical	Gene	Expression|nmod|START_ENTITY Expression|amod|END_ENTITY	Expression of the protein tyrosine phosphatase , phosphatase_of_regenerating_liver_1 , in the outer segments of primate cone photoreceptors .
12147336	0	tyrosine	8,16	phosphatase_receptor-type_C	17,44	tyrosine	phosphatase receptor-type C	CHEBI:18186	5788	Chemical	Gene	START_ENTITY|dobj|distribution distribution|amod|END_ENTITY	Protein tyrosine phosphatase_receptor-type_C exon 4 gene mutation distribution in an Italian multiple_sclerosis population .
10669728	0	tyrosine	43,51	phosphatidylinositol_3-kinase	70,99	tyrosine	phosphatidylinositol 3-kinase	CHEBI:18186	5293	Chemical	Gene	START_ENTITY|dobj|activity activity|amod|END_ENTITY	Caveolin_1-mediated regulation of receptor tyrosine kinase-associated phosphatidylinositol_3-kinase activity by ceramide .
9218614	0	tyrosine	75,83	phosphatidylinositol_3-kinase	124,153	tyrosine	phosphatidylinositol 3-kinase	CHEBI:18186	5295	Chemical	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	CD7-mediated regulation of integrin adhesiveness on human T cells involves tyrosine phosphorylation-dependent activation of phosphatidylinositol_3-kinase .
1372020	0	tyrosine	51,59	phospholipase-C_gamma_1	27,50	tyrosine	phospholipase-C gamma 1	CHEBI:18186	5335	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	CD2/LFA -3 ligation induces phospholipase-C_gamma_1 tyrosine phosphorylation and regulates CD3 signaling .
2466293	0	tyrosine	35,43	phospholipase_C-II	63,81	tyrosine	phospholipase C-II	CHEBI:18186	5335	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Epidermal growth factor stimulates tyrosine phosphorylation of phospholipase_C-II independently of receptor internalization and extracellular calcium .
2472218	0	tyrosine	12,20	phospholipase_C-II	40,58	tyrosine	phospholipase C-II	CHEBI:18186	5335	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	EGF induces tyrosine phosphorylation of phospholipase_C-II : a potential mechanism for EGF_receptor signaling .
12372399	0	tyrosine	35,43	phospholipase_C-gamma1	63,85	tyrosine	phospholipase C-gamma1	CHEBI:18186	5335	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Prostaglandin_F -LRB- 2alpha -RRB- stimulates tyrosine phosphorylation of phospholipase_C-gamma1 .
1281217	0	tyrosine	65,73	phospholipase_C-gamma_1	41,64	tyrosine	phospholipase C-gamma 1	CHEBI:18186	5335	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Stimulation of Fc_gamma_RIIIA results in phospholipase_C-gamma_1 tyrosine phosphorylation and p56lck activation .
1662204	0	tyrosine	12,20	phospholipase_C-gamma_1	40,63	tyrosine	phospholipase C-gamma 1	CHEBI:18186	25738(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	IgE-induced tyrosine phosphorylation of phospholipase_C-gamma_1 in rat_basophilic_leukemia cells .
1712101	0	tyrosine	61,69	phospholipase_C-gamma_1	89,112	tyrosine	phospholipase C-gamma 1	CHEBI:18186	5335	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Functional activation of the T-cell_antigen_receptor induces tyrosine phosphorylation of phospholipase_C-gamma_1 .
2061301	0	tyrosine	41,49	phospholipase_C-gamma_1	69,92	tyrosine	phospholipase C-gamma 1	CHEBI:18186	5335	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	T-cell_antigen_receptor ligation induces tyrosine phosphorylation of phospholipase_C-gamma_1 .
8034732	0	tyrosine	23,31	phospholipase_C-gamma_1	66,89	tyrosine	phospholipase C-gamma 1	CHEBI:18186	5335	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Erythropoietin induces tyrosine phosphorylation and activation of phospholipase_C-gamma_1 in a human erythropoietin-dependent cell line .
10946303	0	tyrosine	146,154	phospholipase_C-gamma_2	97,120	tyrosine	phospholipase C-gamma 2	CHEBI:18186	5336	Chemical	Gene	kinase|amod|START_ENTITY kinase|amod|END_ENTITY	TNF-alpha-induced cyclooxygenase-2 expression in human lung epithelial cells : involvement of the phospholipase_C-gamma_2 , protein_kinase_C-alpha , tyrosine kinase , NF-kappa B-inducing kinase , and I-kappa_B_kinase_1 / 2 pathway .
11507089	0	tyrosine	5,13	phospholipase_C-gamma_2	26,49	tyrosine	phospholipase C-gamma 2	CHEBI:18186	29337(Tax:10116)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Four tyrosine residues in phospholipase_C-gamma_2 , identified as Btk-dependent phosphorylation sites , are required for B_cell_antigen_receptor-coupled calcium signaling .
7523195	0	tyrosine	20,28	phospholipase_C-gamma_2	48,71	tyrosine	phospholipase C-gamma 2	CHEBI:18186	5336	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Collagen stimulates tyrosine phosphorylation of phospholipase_C-gamma_2 but not phospholipase_C-gamma_1 in human platelets .
9475175	0	tyrosine	138,146	phospholipase_C_gamma-1	166,189	tyrosine	phospholipase C gamma-1	CHEBI:18186	25738(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Stimulation of G-protein coupled receptors in vascular smooth muscle cells induces tyrosine kinase dependent increases in calcium without tyrosine phosphorylation of phospholipase_C_gamma-1 .
10100621	0	tyrosine	8,16	phospholipase_C_gamma1	36,58	tyrosine	phospholipase C gamma1	CHEBI:18186	5335	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Role of tyrosine phosphorylation of phospholipase_C_gamma1 in the signaling pathway of HMG-CoA_reductase inhibitor-induced cell death of L6 myoblasts .
20506511	0	tyrosine	54,62	phospholipase_C_gamma1	18,40	tyrosine	phospholipase C gamma1	CHEBI:18186	5335	Chemical	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification of phospholipase_C_gamma1 as a protein tyrosine phosphatase mu substrate that regulates cell migration .
1370350	0	tyrosine	66,74	phospholipase_C_gamma_1	94,117	tyrosine	phospholipase C gamma 1	CHEBI:18186	5335	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Sulfhydryl oxidation down-regulates T-cell signaling and inhibits tyrosine phosphorylation of phospholipase_C_gamma_1 .
8831704	0	tyrosine	36,44	phospholipase_C_gamma_1	64,87	tyrosine	phospholipase C gamma 1	CHEBI:18186	5335	Chemical	Gene	START_ENTITY|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Beta_1_integrin ligation stimulates tyrosine phosphorylation of phospholipase_C_gamma_1 and elevates intracellular Ca2 + in pancreatic acinar cells .
9570517	0	tyrosine	97,105	phospholipase_C_gamma_1	125,148	tyrosine	phospholipase C gamma 1	CHEBI:18186	5335	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	The amino-terminal Src homology 2 domain of phospholipase_C_gamma_1 is essential for TCR-induced tyrosine phosphorylation of phospholipase_C_gamma_1 .
9600070	0	tyrosine	26,34	phospholipase_C_gamma_1	93,116	tyrosine	phospholipase C gamma 1	CHEBI:18186	5335	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Bradykinin stimulates the tyrosine phosphorylation and bradykinin B2_receptor association of phospholipase_C_gamma_1 in vascular endothelial cells .
7628642	0	tyrosine	28,36	phospholipase_C_gamma_2	56,79	tyrosine	phospholipase C gamma 2	CHEBI:18186	5336	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Phenylarsine_oxide inhibits tyrosine phosphorylation of phospholipase_C_gamma_2 in human platelets and phospholipase_C_gamma_1 in NIH-3T3 fibroblasts .
8429012	0	tyrosine	33,41	phospholipase_C_gamma_2	61,84	tyrosine	phospholipase C gamma 2	CHEBI:18186	5336	Chemical	Gene	START_ENTITY|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Cytosolic -LSB- Ca2 + -RSB- homeostasis and tyrosine phosphorylation of phospholipase_C_gamma_2 in HL60 granulocytes .
10215683	0	tyrosine	85,93	phospholipase_Cgamma-1	113,135	tyrosine	phospholipase Cgamma-1	CHEBI:18186	25738(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	A tyrosine kinase signaling pathway , regulated by calcium entry and dissociated from tyrosine phosphorylation of phospholipase_Cgamma-1 , is involved in inositol_phosphate production by activated G protein-coupled receptors in myometrium .
8702743	0	tyrosine	76,84	phospholipase_Cgamma2	54,75	tyrosine	phospholipase Cgamma2	CHEBI:18186	5336	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Negative signaling via FcgammaRIIB1 in B cells blocks phospholipase_Cgamma2 tyrosine phosphorylation but not Syk or Lyn activation .
11459228	0	tyrosine	13,21	phospholipase_D	41,56	tyrosine	phospholipase D	CHEBI:18186	2822	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Differential tyrosine phosphorylation of phospholipase_D isozymes by hydrogen_peroxide and the epidermal growth factor in A431 epidermoid_carcinoma cells .
7526916	0	tyrosine	60,68	phospholipase_D	14,29	tyrosine	phospholipase D	CHEBI:18186	2822	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of phospholipase_D of human platelets by protein tyrosine kinase inhibitors .
10567557	0	tyrosine	20,28	phospholipase_cgamma2	48,69	tyrosine	phospholipase cgamma2	CHEBI:18186	234779(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	LAT is required for tyrosine phosphorylation of phospholipase_cgamma2 and platelet activation by the collagen receptor GPVI .
8951035	0	tyrosine	105,113	phospholipases_A2_and_C	69,92	tyrosine	phospholipases A2 and C	CHEBI:18186	151056	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Signaling responses to alkyllysophosphatidic_acid : the activation of phospholipases_A2_and_C and protein tyrosine phosphorylation in human platelets .
25132343	0	tyrosine	55,63	placenta_growth_factor	14,36	tyrosine	placenta growth factor	CHEBI:18186	5228	Chemical	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of placenta_growth_factor , soluble fms-like tyrosine kinase-1 , metal-responsive_transcription_factor-1 , heme_oxygenase_1 and hypoxia_inducible_factor-1a mRNAs in pre-eclampsia_placenta and the effect of pre-eclampsia sera on their expression of choriocarcinoma cells .
22433027	0	tyrosine	102,110	placental_growth_factor	24,47	tyrosine	placental growth factor	CHEBI:18186	5228	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Accuracy of circulating placental_growth_factor , vascular_endothelial_growth_factor , soluble fms-like tyrosine kinase 1 and soluble endoglin in the prediction of pre-eclampsia : a systematic review and meta-analysis .
26387758	0	tyrosine	84,92	placental_growth_factor	39,62	tyrosine	placental growth factor	D014443	5228	Chemical	Gene	START_ENTITY|nsubj|changes changes|nmod|END_ENTITY	Longitudinal changes in maternal serum placental_growth_factor and soluble fms-like tyrosine kinase-1 in women at increased risk of preeclampsia .
26387758	0	tyrosine	84,92	placental_growth_factor	39,62	tyrosine	placental growth factor	D014443	5228	Chemical	Gene	START_ENTITY|nsubj|changes changes|nmod|END_ENTITY	Longitudinal changes in maternal serum placental_growth_factor and soluble fms-like tyrosine kinase-1 in women at increased risk of preeclampsia .
25501895	0	tyrosine	15,23	plakophilin_3	43,56	tyrosine	plakophilin 3	CHEBI:18186	11187	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	c-Src mediated tyrosine phosphorylation of plakophilin_3 as a new mechanism to control desmosome composition in cells exposed to oxidative stress .
22320850	0	tyrosine	139,147	platelet-derived_growth_factor_receptor	99,138	tyrosine	platelet-derived growth factor receptor	CHEBI:18186	5159	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	A novel pyrrolo -LSB- 3 , _ 2-d -RSB- pyrimidine derivative , as a vascular_endothelial_growth_factor_receptor and platelet-derived_growth_factor_receptor tyrosine kinase inhibitor , shows potent antitumor activity by suppression of tumor angiogenesis .
8843147	0	tyrosine	106,114	platelet-derived_growth_factor_receptor	66,105	tyrosine	platelet-derived growth factor receptor	CHEBI:18186	5159	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Amino-terminal sequence determinants for substrate recognition by platelet-derived_growth_factor_receptor tyrosine kinase .
9784112	0	tyrosine	178,186	platelet-derived_growth_factor_receptor	138,177	tyrosine	platelet-derived growth factor receptor	CHEBI:18186	5159	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Synthesis and tyrosine kinase inhibitory activity of a series of 2-amino-8H-pyrido -LSB- 2,3-d -RSB- pyrimidines : identification of potent , selective platelet-derived_growth_factor_receptor tyrosine kinase inhibitors .
17940969	0	tyrosine	102,110	platelet_endothelial_cell_adhesion_molecule-1	130,175	tyrosine	platelet endothelial cell adhesion molecule-1	CHEBI:18186	5175	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Breakdown of paraendothelial barrier function during Marburg virus_infection is associated with early tyrosine phosphorylation of platelet_endothelial_cell_adhesion_molecule-1 .
15925565	0	tyrosine	128,136	pleiotrophin	163,175	tyrosine	pleiotrophin	CHEBI:18186	5764	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|Fyn Fyn|nmod|END_ENTITY	Fyn is a downstream target of the pleiotrophin/receptor protein tyrosine phosphatase beta/zeta-signaling pathway : regulation of tyrosine phosphorylation of Fyn by pleiotrophin .
15925565	0	tyrosine	64,72	pleiotrophin	163,175	tyrosine	pleiotrophin	CHEBI:18186	5764	Chemical	Gene	phosphatase|amod|START_ENTITY pathway|amod|phosphatase pathway|dep|regulation regulation|nmod|phosphorylation phosphorylation|nmod|Fyn Fyn|nmod|END_ENTITY	Fyn is a downstream target of the pleiotrophin/receptor protein tyrosine phosphatase beta/zeta-signaling pathway : regulation of tyrosine phosphorylation of Fyn by pleiotrophin .
19141530	0	tyrosine	138,146	pleiotrophin	30,42	tyrosine	pleiotrophin	CHEBI:18186	5764	Chemical	Gene	beta/zeta|compound|START_ENTITY required|nmod|beta/zeta receptor|acl|required receptor|compound|END_ENTITY	Integrin_alpha -LRB- v -RRB- beta -LRB- 3 -RRB- is a pleiotrophin receptor required for pleiotrophin-induced endothelial cell migration through receptor protein tyrosine phosphatase beta/zeta .
23333521	0	tyrosine	70,78	pleiotrophin	32,44	tyrosine	pleiotrophin	CHEBI:18186	5764	Chemical	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of the growth factor pleiotrophin and its receptor protein tyrosine phosphatase beta/zeta in the serum , cartilage and subchondral bone of patients with osteoarthritis .
23777859	4	tyrosine	548,556	pleiotrophin	479,491	tyrosine	Pleiotrophin	CHEBI:18186	5764	Chemical	Gene	phosphatase|nsubj|START_ENTITY phosphatase|ccomp|shown shown|advcl|interacts interacts|nsubj|END_ENTITY	It is shown that activation of ALK results when the cytokine pleiotrophin -LRB- PTN -RRB- interacts with its receptor , the receptor protein tyrosine phosphatase b / -LRB- RPTPb / -RRB- .
26615567	0	tyrosine	89,97	pleiotrophin	51,63	tyrosine	pleiotrophin	D014443	24924(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|loading loading|nmod|expression expression|nmod|END_ENTITY	Effects of mechanical loading on the expression of pleiotrophin and its receptor protein tyrosine phosphatase beta/zeta in a rat spinal_deformity model .
15375158	0	tyrosine	42,50	polysomal_ribonuclease_1	70,94	tyrosine	polysomal ribonuclease 1	CHEBI:18186	398084(Tax:8355)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Endonuclease-mediated mRNA decay requires tyrosine phosphorylation of polysomal_ribonuclease_1 -LRB- PMR1 -RRB- for the targeting and degradation of polyribosome-bound substrate mRNA .
7505391	0	tyrosine	85,93	pp125FAK	102,110	tyrosine	pp125FAK	CHEBI:18186	396416(Tax:9031)	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase , pp125FAK .
7542880	0	tyrosine	38,46	pp125FAK	88,96	tyrosine	pp125FAK	CHEBI:18186	5747	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Stretching mesangial cells stimulates tyrosine phosphorylation of focal adhesion kinase pp125FAK .
7673357	0	tyrosine	9,17	pp125FAK	0,8	tyrosine	pp125FAK	CHEBI:18186	14083(Tax:10090)	Chemical	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	pp125FAK tyrosine kinase activity is not required for the assembly of F-actin stress fibres and focal adhesions in cultured mouse aortic smooth muscle cells .
8280049	0	tyrosine	106,114	pp125FAK	134,142	tyrosine	pp125FAK	CHEBI:18186	5747	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Platelet adhesion to collagen via the alpha 2 beta 1 integrin under arterial flow conditions causes rapid tyrosine phosphorylation of pp125FAK .
8547637	0	tyrosine	27,35	pp125FAK	55,63	tyrosine	pp125FAK	CHEBI:18186	5747	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Protein_kinase_C regulates tyrosine phosphorylation of pp125FAK in platelets adherent to fibrinogen .
8719888	0	tyrosine	79,87	pp125FAK	107,115	tyrosine	pp125FAK	CHEBI:18186	14083(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Integrin signaling : roles for the cytoplasmic tails of alpha_IIb beta 3 in the tyrosine phosphorylation of pp125FAK .
1848858	1	tyrosine	98,106	pp15	85,89	tyrosine	pp15	CHEBI:18186	68051(Tax:10090)	Chemical	Gene	phosphatases|compound|START_ENTITY phosphatases|amod|END_ENTITY	Characterization of two membrane-bound pp15 protein tyrosine phosphatases from 3T3-L1 adipocytes .
2848242	0	tyrosine	108,116	pp15	53,57	tyrosine	pp15	CHEBI:18186	68051(Tax:10090)	Chemical	Gene	target|nmod|START_ENTITY END_ENTITY|appos|target	Identification of phosphorylated 422 -LRB- aP2 -RRB- protein as pp15 , the 15-kilodalton target of the insulin receptor tyrosine kinase in 3T3-L1 adipocytes .
2022647	0	tyrosine	106,114	pp185	46,51	tyrosine	pp185	CHEBI:18186	25467(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|analysis analysis|nmod|END_ENTITY	Purification and partial sequence analysis of pp185 , the major cellular substrate of the insulin receptor tyrosine kinase .
2431281	0	tyrosine	17,25	pp60c-src	45,54	tyrosine	pp60c-src	CHEBI:18186	20779(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Altered sites of tyrosine phosphorylation in pp60c-src associated with polyomavirus middle_tumor antigen .
8514886	0	tyrosine	26,34	pp60c-src	16,25	tyrosine	pp60c-src	CHEBI:18186	20779(Tax:10090)	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	Herbimycin_A , a pp60c-src tyrosine kinase inhibitor , inhibits osteoclastic bone resorption in vitro and hypercalcemia in vivo .
8569183	0	tyrosine	39,47	pp60c-src	85,94	tyrosine	pp60c-src	CHEBI:18186	83805(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|activity activity|nmod|END_ENTITY	Increased immunoreactivity and protein tyrosine kinase activity of the protooncogene pp60c-src in preneoplastic_lesions in rat pancreas .
8755732	0	tyrosine	60,68	pp60c-src	45,54	tyrosine	pp60c-src	CHEBI:18186	20779(Tax:10090)	Chemical	Gene	kinase|amod|START_ENTITY END_ENTITY|nmod|kinase	Correlation of the phosphorylation states of pp60c-src with tyrosine kinase activity : the intramolecular pY530-SH2 complex retains significant activity if Y419 is phosphorylated .
3001059	0	tyrosine	139,147	progesterone_receptor	36,57	tyrosine	progesterone receptor	CHEBI:18186	5241	Chemical	Gene	START_ENTITY|nsubj|phosphorylation phosphorylation|nmod|END_ENTITY	Differential phosphorylation of the progesterone_receptor by insulin , epidermal_growth_factor , and platelet-derived growth factor receptor tyrosine protein kinases .
10938266	0	tyrosine	13,21	prolactin	83,92	tyrosine	prolactin	CHEBI:18186	5617	Chemical	Gene	START_ENTITY|nmod|secretion secretion|nmod|END_ENTITY	Constitutive tyrosine phosphorylation of ErbB-2 via Jak2 by autocrine secretion of prolactin in human breast_cancer .
1312959	0	tyrosine	12,20	prolactin	68,77	tyrosine	prolactin	CHEBI:18186	5617	Chemical	Gene	inhibitor|amod|START_ENTITY Effect|nmod|inhibitor Effect|nmod|actions actions|nmod|END_ENTITY	Effect of a tyrosine kinase inhibitor , genistein , on the actions of prolactin in cultured mouse mammary tissues .
15878970	0	tyrosine	41,49	prolactin	94,103	tyrosine	prolactin	CHEBI:18186	5617	Chemical	Gene	phosphatase|nsubj|START_ENTITY phosphatase|xcomp|increase increase|dobj|expression expression|amod|END_ENTITY	Integrin activates receptor-like protein tyrosine phosphatase alpha , Src , and Rho to increase prolactin gene expression through a final phosphatidylinositol 3-kinase/cytoskeletal pathway that is additive with insulin .
1639035	0	tyrosine	36,44	prolactin	64,73	tyrosine	prolactin	CHEBI:18186	24683(Tax:10116)	Chemical	Gene	stimulation|nmod|START_ENTITY Evidence|nmod|stimulation kinase|nsubj|Evidence kinase|nmod|END_ENTITY	Evidence for a rapid stimulation of tyrosine kinase activity by prolactin in Nb2 rat lymphoma cells .
1975656	0	tyrosine	49,57	prolactin	10,19	tyrosine	prolactin	CHEBI:18186	19109(Tax:10090)	Chemical	Gene	number|nmod|START_ENTITY replacement|nmod|number replacement|compound|END_ENTITY	Effect of prolactin replacement on the number of tyrosine hydroxylase expressing neurons in the arcuate nuclei of Ames dwarf and normal mice .
7508935	0	tyrosine	34,42	prolactin	58,67	tyrosine	prolactin	CHEBI:18186	24683(Tax:10116)	Chemical	Gene	Activation|nmod|START_ENTITY kinase|nsubj|Activation kinase|nmod|END_ENTITY	Activation of receptor-associated tyrosine kinase JAK2 by prolactin .
8013458	0	tyrosine	30,38	prolactin	74,83	tyrosine	prolactin	CHEBI:18186	19109(Tax:10090)	Chemical	Gene	Identification|nmod|START_ENTITY kinases|nsubj|Identification kinases|advcl|signaling signaling|nmod|END_ENTITY	Identification of JAK protein tyrosine kinases as signaling molecules for prolactin .
8147889	0	tyrosine	26,34	prolactin	57,66	tyrosine	prolactin	CHEBI:18186	24683(Tax:10116)	Chemical	Gene	involvement|nmod|START_ENTITY kinase|nsubj|involvement kinase|nmod|secretion secretion|compound|END_ENTITY	A possible involvement of tyrosine kinase in TRH-induced prolactin secretion in GH3 cells .
9296518	0	tyrosine	23,31	prolactin	67,76	tyrosine	prolactin	CHEBI:18186	24683(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|inhibitor inhibitor|nmod|expression expression|compound|END_ENTITY	Effects of the protein tyrosine kinase inhibitor , herbimycin_A , on prolactin gene expression in GH3 and 235-1 pituitary_tumor cells .
11328862	0	tyrosine	38,46	prolactin_receptor	69,87	tyrosine	prolactin receptor	CHEBI:18186	5618	Chemical	Gene	kinase|compound|START_ENTITY kinase|nmod|END_ENTITY	Activation and association of the Tec tyrosine kinase with the human prolactin_receptor : mapping of a Tec/Vav1-receptor binding site .
7592639	1	tyrosine	122,130	prolactin_receptor	94,112	tyrosine	prolactin receptor	CHEBI:18186	100757415	Chemical	Gene	START_ENTITY|nsubj|association association|nmod|END_ENTITY	Functional association with prolactin_receptor and JAK2 tyrosine kinase .
8188682	0	tyrosine	54,62	prolactin_receptor	86,104	tyrosine	prolactin receptor	CHEBI:18186	5618	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Prolactin-induced proliferation of Nb2 cells involves tyrosine phosphorylation of the prolactin_receptor and its associated tyrosine kinase JAK2 .
25180269	0	tyrosine	66,74	proline-rich_tyrosine_kinase_2	32,62	tyrosine	proline-rich tyrosine kinase 2	CHEBI:18186	2185	Chemical	Gene	phosphorylation|amod|START_ENTITY END_ENTITY|nmod|phosphorylation	Evidence for the involvement of proline-rich_tyrosine_kinase_2 in tyrosine phosphorylation downstream of protein kinase A activation during human sperm capacitation .
19140736	0	tyrosine	24,32	proline_dehydrogenase	44,65	tyrosine	proline dehydrogenase	CHEBI:18186	5625	Chemical	Gene	residue|compound|START_ENTITY residue|nmod|END_ENTITY	A conserved active site tyrosine residue of proline_dehydrogenase helps enforce the preference for proline over hydroxyproline as the substrate .
16507567	0	tyrosine	17,25	protein-tyrosine_phosphatase-alpha	45,79	tyrosine	protein-tyrosine phosphatase-alpha	CHEBI:18186	5786	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Integrin-induced tyrosine phosphorylation of protein-tyrosine_phosphatase-alpha is required for cytoskeletal reorganization and cell migration .
11007774	0	tyrosine	63,71	protein-tyrosine_phosphatase_1B	18,49	tyrosine	protein-tyrosine phosphatase 1B	CHEBI:18186	19246(Tax:10090)	Chemical	Gene	activity|amod|START_ENTITY END_ENTITY|nmod|activity	Identification of protein-tyrosine_phosphatase_1B as the major tyrosine phosphatase activity capable of dephosphorylating and activating c-Src in several human breast_cancer cell lines .
3742488	0	tyrosine	57,65	protein_kinase	66,80	tyrosine	protein kinase	CHEBI:18186	64030(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	A differential effect of the Walker 256 carcinoma on the tyrosine protein_kinase activity of liver plasma membrane domains .
15994200	0	tyrosine	31,39	protein_kinase_B	14,30	tyrosine	protein kinase B	CHEBI:18186	2185	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of protein_kinase_B tyrosine phosphorylation by thyroid-specific oncogenic RET/PTC kinases .
11750911	0	tyrosine	149,157	protein_kinase_C	131,147	tyrosine	protein kinase C	CHEBI:18186	24681(Tax:10116)	Chemical	Gene	kinase|amod|START_ENTITY kinase|amod|END_ENTITY	Functional coupling of rat metabotropic glutamate 1a receptors to phospholipase D in CHO cells : involvement of extracellular Ca2 + , protein_kinase_C , tyrosine kinase and Rho-A .
10946303	0	tyrosine	146,154	protein_kinase_C-alpha	122,144	tyrosine	protein kinase C-alpha	CHEBI:18186	5578	Chemical	Gene	kinase|amod|START_ENTITY kinase|amod|END_ENTITY	TNF-alpha-induced cyclooxygenase-2 expression in human lung epithelial cells : involvement of the phospholipase_C-gamma_2 , protein_kinase_C-alpha , tyrosine kinase , NF-kappa B-inducing kinase , and I-kappa_B_kinase_1 / 2 pathway .
11502860	0	tyrosine	57,65	protein_kinase_C-delta	92,114	tyrosine	protein kinase C-delta	CHEBI:18186	18753(Tax:10090)	Chemical	Gene	events|amod|START_ENTITY events|nmod|END_ENTITY	Rottlerin-independent attenuation of pervanadate-induced tyrosine phosphorylation events by protein_kinase_C-delta in hemopoietic cells .
8621384	0	tyrosine	90,98	protein_kinase_C_delta	118,140	tyrosine	protein kinase C delta	CHEBI:18186	18753(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Activation of the epidermal_growth_factor_receptor signal transduction pathway stimulates tyrosine phosphorylation of protein_kinase_C_delta .
11498535	0	tyrosine	118,126	protein_kinase_Cdelta	96,117	tyrosine	protein kinase Cdelta	CHEBI:18186	170538(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Rottlerin is a mitochondrial uncoupler that decreases cellular ATP levels and indirectly blocks protein_kinase_Cdelta tyrosine phosphorylation .
16891660	0	tyrosine	32,40	protein_kinase_D	15,31	tyrosine	protein kinase D	CHEBI:18186	5587	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Requirement of protein_kinase_D tyrosine phosphorylation for VEGF-A165-induced angiogenesis through its interaction and regulation of phospholipase Cgamma phosphorylation .
18055543	0	tyrosine	83,91	ptprz1	68,74	tyrosine	ptprz1	CHEBI:18186	25613(Tax:10116)	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|amod|END_ENTITY	Chronic oxidative stress causes amplification and overexpression of ptprz1 protein tyrosine phosphatase to activate beta-catenin pathway .
10430614	0	tyrosine	12,20	pyk2	28,32	tyrosine	pyk2	CHEBI:18186	2185	Chemical	Gene	Role|nmod|START_ENTITY kinase|nsubj|Role kinase|dobj|END_ENTITY	Role of the tyrosine kinase pyk2 in the integrin-dependent activation of human neutrophils by TNF .
23640882	0	tyrosine	61,69	pyruvate_kinase_M2	42,60	tyrosine	pyruvate kinase M2	D014443	5315	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Protein_tyrosine_phosphatase_1B regulates pyruvate_kinase_M2 tyrosine phosphorylation .
1639773	0	tyrosine	29,37	raf-1	79,84	tyrosine	raf-1	CHEBI:18186	5894	Chemical	Gene	translocation|amod|START_ENTITY translocation|nmod|END_ENTITY	Interleukin-2 -LRB- IL-2 -RRB- induces tyrosine kinase-dependent translocation of active raf-1 from the IL-2_receptor into the cytosol .
8918833	0	tyrosine	48,56	rapsyn	31,37	tyrosine	rapsyn	CHEBI:18186	5913	Chemical	Gene	phosphorylation|amod|START_ENTITY regulates|dobj|phosphorylation regulates|nsubj|END_ENTITY	The synapse-associated protein rapsyn regulates tyrosine phosphorylation of proteins colocalized at nicotinic acetylcholine receptor clusters .
2837654	0	tyrosine	15,23	receptor	75,83	tyrosine	receptor	CHEBI:18186	12978(Tax:10090)	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Ligand-induced tyrosine kinase activity of the colony-stimulating factor 1 receptor in a murine macrophage cell line .
8948575	0	tyrosine	24,32	receptor_tyrosine_kinase	77,101	tyrosine	receptor tyrosine kinase	CHEBI:18186	38559(Tax:7227)	Chemical	Gene	START_ENTITY|nmod|pathways pathways|compound|END_ENTITY	The nonreceptor protein tyrosine phosphatase corkscrew functions in multiple receptor_tyrosine_kinase pathways in Drosophila .
12701883	0	tyrosine	105,113	ret	101,104	tyrosine	ret	CHEBI:18186	19713(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Internalization Internalization|nmod|GFR_alpha_1 GFR_alpha_1|nmod|absence absence|nmod|END_ENTITY	Internalization of glial cell-derived neurotrophic factor receptor GFR_alpha_1 in the absence of the ret tyrosine kinase coreceptor .
12759189	0	tyrosine	37,45	ret	24,27	tyrosine	ret	CHEBI:18186	19713(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	3 ' Splicing variants of ret receptor tyrosine kinase are differentially expressed in mouse embryos and in adult mice .
1958211	0	tyrosine	77,85	ret	4,7	tyrosine	ret	CHEBI:18186	19713(Tax:10090)	Chemical	Gene	residues|amod|START_ENTITY phosphorylated|nmod|residues glycoproteins|acl|phosphorylated glycoproteins|nsubj|products products|compound|END_ENTITY	The ret oncogene products are membrane-bound glycoproteins phosphorylated on tyrosine residues in vivo .
3078962	0	tyrosine	60,68	ret	30,33	tyrosine	ret	CHEBI:18186	19713(Tax:10090)	Chemical	Gene	kinase|amod|START_ENTITY encoding|dobj|kinase proto-oncogene|xcomp|encoding proto-oncogene|nsubj|Cloning Cloning|nmod|END_ENTITY	Cloning and expression of the ret proto-oncogene encoding a tyrosine kinase with two potential transmembrane domains .
7608542	0	tyrosine	43,51	ret	39,42	tyrosine	ret	CHEBI:18186	19713(Tax:10090)	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Differential expression of the blk and ret tyrosine kinases during B lineage development is dependent on Ig rearrangement .
7678053	0	tyrosine	105,113	ret	101,104	tyrosine	ret	CHEBI:18186	5979	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Molecular characterization of a thyroid_tumor-specific transforming sequence formed by the fusion of ret tyrosine kinase and the regulatory subunit RI alpha of cyclic_AMP-dependent protein kinase A .
8363602	0	tyrosine	18,26	ret	14,17	tyrosine	ret	CHEBI:18186	5979	Chemical	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of ret tyrosine kinase activity by herbimycin_A .
8637703	0	tyrosine	18,26	ret	88,91	tyrosine	ret	CHEBI:18186	5979	Chemical	Gene	residues|amod|START_ENTITY residues|acl:relcl|essential essential|advcl|transforming transforming|dobj|activity activity|nmod|END_ENTITY	Identification of tyrosine residues that are essential for transforming activity of the ret proto-oncogene with MEN2A or MEN2B mutation .
8674117	0	tyrosine	43,51	ret	31,34	tyrosine	ret	CHEBI:18186	24716(Tax:10116)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha , a novel receptor for GDNF .
8784097	2	tyrosine	260,268	ret	290,293	tyrosine	ret	CHEBI:18186	5979	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|protooncogene protooncogene|compound|END_ENTITY	Three forms of this oncogene , formed by translocation of three different genes to the tyrosine kinase domain of the ret protooncogene , result in constitutive kinase activation .
24266348	0	tyrosine	17,25	ron	4,7	tyrosine	ron	CHEBI:18186	4486	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	The ron receptor tyrosine kinase : a key regulator of inflammation and cancer progression .
10716948	0	tyrosine	21,29	shark	15,20	tyrosine	shark	CHEBI:18186	44353(Tax:7227)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	The Drosophila shark tyrosine kinase is required for embryonic dorsal closure .
19290061	0	tyrosine	114,122	shp2	109,113	tyrosine	shp2	CHEBI:18186	19247(Tax:10090)	Chemical	Gene	phosphatase|compound|START_ENTITY phosphatase|amod|END_ENTITY	A conserved mechanism for control of human and mouse embryonic stem cell pluripotency and differentiation by shp2 tyrosine phosphatase .
20685990	0	tyrosine	14,22	signal_regulatory_protein_a	42,69	tyrosine	signal regulatory protein a	CHEBI:18186	19261(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Stress-evoked tyrosine phosphorylation of signal_regulatory_protein_a regulates behavioral immobility in the forced swim test .
12637586	0	tyrosine	145,153	signal_transducer_and_activator_of_transcription_3	14,64	tyrosine	signal transducer and activator of transcription 3	CHEBI:18186	20848(Tax:10090)	Chemical	Gene	kinase|amod|START_ENTITY kinase|amod|END_ENTITY	Activation of signal_transducer_and_activator_of_transcription_3 by oncogenic RET/PTC -LRB- rearranged in transformation/papillary _ thyroid_carcinoma -RRB- tyrosine kinase : roles in specific gene regulation and cellular transformation .
22374428	0	tyrosine	87,95	signal_transducer_and_activator_of_transcription_3	115,165	tyrosine	signal transducer and activator of transcription 3	CHEBI:18186	6774	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tissue microarray-based study of patients with lymph node-positive_breast_cancer shows tyrosine phosphorylation of signal_transducer_and_activator_of_transcription_3 -LRB- tyrosine705-STAT3 -RRB- is a marker of good prognosis .
24391004	0	tyrosine	66,74	sp32	53,57	tyrosine	sp32	CHEBI:18186	397317(Tax:9823)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Activation of proacrosin accompanies upregulation of sp32 protein tyrosine phosphorylation in pig sperm .
10231057	0	tyrosine	33,41	sperm_tail_protein	14,32	tyrosine	sperm tail protein	CHEBI:18186	6676	Chemical	Gene	START_ENTITY|nsubj|Modulation Modulation|nmod|END_ENTITY	Modulation of sperm_tail_protein tyrosine phosphorylation by pentoxifylline and its correlation with hyperactivated_motility .
10353598	0	tyrosine	49,57	src	77,80	tyrosine	src	CHEBI:18186	6714	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Regulation of mRNA splicing and transport by the tyrosine kinase activity of src .
10441393	0	tyrosine	58,66	src	46,49	tyrosine	src	CHEBI:18186	6714	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Benzodiazepine compounds as inhibitors of the src protein tyrosine kinase : screening of a combinatorial library of 1,4-benzodiazepines .
11038351	1	tyrosine	167,175	src	151,154	tyrosine	src	CHEBI:18186	6714	Chemical	Gene	START_ENTITY|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of GPIa/IIa-associated src and protein tyrosine phosphorylation .
11078204	0	tyrosine	18,26	src	14,17	tyrosine	src	CHEBI:18186	6714	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Inhibitors of src tyrosine kinase : the preparation and structure-activity relationship of 4-anilino-3-cyanoquinolines and 4-anilinoquinazolines .
11320329	0	tyrosine	151,159	src	147,150	tyrosine	src	CHEBI:18186	396442(Tax:9031)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Post-translational modification of the N-terminal His tag interferes with the crystallization of the wild-type and mutant SH3 domains from chicken src tyrosine kinase .
11880195	0	tyrosine	208,216	src	204,207	tyrosine	src	CHEBI:18186	6714	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Insulin-induced expression of the activity-regulated cytoskeleton-associated gene -LRB- ARC -RRB- in human neuroblastoma cells requires p21 -LRB- ras -RRB- , mitogen-activated protein kinase/extracellular regulated kinase and src tyrosine kinases but is protein kinase C-independent .
11948246	0	tyrosine	144,152	src	140,143	tyrosine	src	CHEBI:18186	20779(Tax:10090)	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	The production of macrophage_inflammatory_protein-2 induced by soluble intercellular adhesion molecule-1 in mouse astrocytes is mediated by src tyrosine kinases and p42/44 mitogen-activated protein kinase .
1370575	0	tyrosine	75,83	src	55,58	tyrosine	src	CHEBI:18186	83805(Tax:10116)	Chemical	Gene	kinases|compound|START_ENTITY kinases|amod|END_ENTITY	Engagement of the high-affinity IgE receptor activates src protein-related tyrosine kinases .
2163753	0	tyrosine	155,163	src	151,154	tyrosine	src	CHEBI:18186	83805(Tax:10116)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Functional expression of dihydropyridine-insensitive calcium channels during PC12 cell differentiation by nerve growth factor -LRB- NGF -RRB- , oncogenic ras , or src tyrosine kinase .
2973411	0	tyrosine	44,52	src	40,43	tyrosine	src	CHEBI:18186	6714	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	p36 , the major cytoplasmic substrate of src tyrosine protein kinase , binds to its p11 regulatory subunit via a short amino-terminal amphiphatic helix .
7692368	0	tyrosine	39,47	src	27,30	tyrosine	src	CHEBI:18186	6714	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Regulation of the cellular src protein tyrosine kinase : interactions of the carboxyl terminal sequences residing between the kinase domain and tyrosine-527 .
9584165	0	tyrosine	115,123	src	111,114	tyrosine	src	CHEBI:18186	20779(Tax:10090)	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	RACK1 , a receptor_for_activated_C_kinase and a homolog of the beta subunit of G proteins , inhibits activity of src tyrosine kinases and growth of NIH 3T3 cells .
7528668	0	tyrosine	22,30	stat3	76,81	tyrosine	stat3	CHEBI:18186	6774	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Interleukin-2 induces tyrosine phosphorylation and nuclear translocation of stat3 in human T lymphocytes .
1382699	0	tyrosine	48,56	steel_factor	93,105	tyrosine	steel factor	CHEBI:18186	4254	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Recombinant human interleukin-9 induces protein tyrosine phosphorylation and synergizes with steel_factor to stimulate proliferation of the human factor-dependent cell line , M07e .
16155937	0	tyrosine	128,136	stem_cell_factor	144,160	tyrosine	stem cell factor	CHEBI:18186	17311(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Interaction and functional cooperation between the serine/threonine kinase bone_morphogenetic_protein_type_II_receptor with the tyrosine kinase stem_cell_factor receptor .
17662946	0	tyrosine	48,56	stem_cell_factor	71,87	tyrosine	stem cell factor	CHEBI:18186	4254	Chemical	Gene	activation|nmod|START_ENTITY basis|nmod|activation kinase|nsubj|basis kinase|nmod|END_ENTITY	Structural basis for activation of the receptor tyrosine kinase KIT by stem_cell_factor .
18423881	0	tyrosine	49,57	stem_cell_factor	15,31	tyrosine	stem cell factor	CHEBI:18186	17311(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of stem_cell_factor and its receptor tyrosine kinase c-kit in pain regulation .
20846303	0	tyrosine	66,74	stem_cell_factor	12,28	tyrosine	stem cell factor	CHEBI:18186	4254	Chemical	Gene	inhibitors|amod|START_ENTITY have|nsubj|inhibitors role|parataxis|have role|nmod|END_ENTITY	The role of stem_cell_factor and c-KIT in keloid pathogenesis : do tyrosine kinase inhibitors have a potential therapeutic role ?
7526158	0	tyrosine	40,48	stem_cell_factor	88,104	tyrosine	stem cell factor	CHEBI:18186	4254	Chemical	Gene	phosphorylated|advmod|START_ENTITY phosphorylated|nmod|END_ENTITY	Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem_cell_factor binding .
9376582	0	tyrosine	119,127	stem_cell_factor	24,40	tyrosine	stem cell factor	CHEBI:18186	4254	Chemical	Gene	role|nmod|START_ENTITY kinase-mediated|nsubj|role impairs|parataxis|kinase-mediated impairs|nsubj|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of human stem_cell_factor impairs melanocyte , mast cell , and thymocyte development : a role for receptor tyrosine kinase-mediated mitogen activated protein kinase activation in cell differentiation .
9444944	0	tyrosine	148,156	stem_cell_factor	30,46	tyrosine	stem cell factor	CHEBI:18186	4254	Chemical	Gene	phosphorylation|amod|START_ENTITY increase|nmod|phosphorylation Analysis|dep|increase Analysis|nmod|synergism synergism|nmod|END_ENTITY	Analysis of synergism between stem_cell_factor and granulocyte-macrophage_colony-stimulating_factor on human megakaryoblastic cells : an increase in tyrosine phosphorylation of 145 kDa subunit of c-kit in two-factor combination .
2435394	0	tyrosine	54,62	substance_P	11,22	tyrosine	substance P	CHEBI:18186	281512(Tax:9913)	Chemical	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Effects of substance_P on the long-term regulation of tyrosine hydroxylase activity and catecholamine levels in cultured adrenal chromaffin cells .
11465115	0	tyrosine	12,20	syk	28,31	tyrosine	syk	CHEBI:18186	25155(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	The protein tyrosine kinase syk activity is reduced by clustering the mast_cell_function-associated_antigen .
19124456	0	tyrosine	8,16	syk	25,28	tyrosine	Syk	CHEBI:18186	6850	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	Protein tyrosine kinase , syk : a key player in phagocytic cells .
24900823	0	tyrosine	39,47	syk	56,59	tyrosine	syk	D014443	6850	Chemical	Gene	START_ENTITY|dobj|inhibitors inhibitors|appos|END_ENTITY	Phenyl_carboxamide analogues as spleen tyrosine kinase -LRB- syk -RRB- inhibitors .
7639745	0	tyrosine	53,61	syk	41,44	tyrosine	syk	CHEBI:18186	20963(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|characterization characterization|nmod|protein protein|compound|END_ENTITY	Molecular characterization of the murine syk protein tyrosine kinase cDNA , transcripts and protein .
8598449	1	tyrosine	116,124	syk	112,115	tyrosine	syk	CHEBI:18186	6850	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Rapid induction of tyrosine phosphorylation , activation of syk tyrosine kinase , and phosphorylation of phospholipase C-gamma and phosphatidylinositol 3-kinase .
9028946	0	tyrosine	35,43	syk	63,66	tyrosine	syk	CHEBI:18186	6850	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	A collagen-like peptide stimulates tyrosine phosphorylation of syk and phospholipase_C_gamma2 in platelets independent of the integrin alpha2beta1 .
9707420	0	tyrosine	12,20	syk	0,3	tyrosine	syk	CHEBI:18186	6850	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	syk protein tyrosine kinase regulates Fc receptor gamma-chain-mediated transport to lysosomes .
15821731	0	tyrosine	72,80	synaptojanin_1	100,114	tyrosine	synaptojanin 1	CHEBI:18186	8867	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	EphrinB-EphB signalling regulates clathrin-mediated endocytosis through tyrosine phosphorylation of synaptojanin_1 .
8870647	0	tyrosine	57,65	syndecan-1	98,108	tyrosine	syndecan-1	CHEBI:18186	20969(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Pervanadate activation of intracellular kinases leads to tyrosine phosphorylation and shedding of syndecan-1 .
7958865	0	tyrosine	74,82	tek	91,94	tyrosine	tek	CHEBI:18186	21687(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase , tek , reveal a critical role in vasculogenesis of the embryo .
10440258	10	tyrosine	1737,1745	thrombin	1807,1815	tyrosine	thrombin	CHEBI:18186	2147	Chemical	Gene	kinases|amod|START_ENTITY activated|nsubjpass|kinases activated|nmod|epithelium epithelium|nmod|lenses lenses|acl|exposed exposed|nmod|END_ENTITY	Results from Western blot studies suggested that tyrosine kinases are activated in the epithelium of lenses exposed to thrombin .
10544927	0	tyrosine	102,110	thrombin	53,61	tyrosine	thrombin	CHEBI:18186	29251(Tax:10116)	Chemical	Gene	kinase/phosphatase|compound|START_ENTITY modulation|nmod|kinase/phosphatase release|dep|modulation release|nmod|-2 -2|nmod|END_ENTITY	Rapid release of matrix_metalloproteinase _ -LRB- MMP -RRB- -2 by thrombin in the rat aorta : modulation by protein tyrosine kinase/phosphatase .
1372480	0	tyrosine	46,54	thrombin	95,103	tyrosine	thrombin	CHEBI:18186	2147	Chemical	Gene	phosphorylation|amod|START_ENTITY sodium_nitroprusside|nmod|phosphorylation Inhibition|nmod|sodium_nitroprusside induced|nsubj|Inhibition induced|nmod|END_ENTITY	Inhibition by sodium_nitroprusside or PGE1 of tyrosine phosphorylation induced in platelets by thrombin or ADP .
15313016	0	tyrosine	71,79	thrombin	34,42	tyrosine	thrombin	CHEBI:18186	2147	Chemical	Gene	dephosphorylation|amod|START_ENTITY associated|nmod|dephosphorylation associated|nsubjpass|stimulation stimulation|nmod|receptor receptor|compound|END_ENTITY	Sustained stimulation of platelet thrombin receptor is associated with tyrosine dephosphorylation of a novel p67 peptide in a manner regulated by extracellular calcium .
16287612	0	tyrosine	10,18	thrombin	82,90	tyrosine	thrombin	CHEBI:18186	2147	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|proteins proteins|nmod|activation activation|nmod|platelets platelets|nmod|END_ENTITY	Efficient tyrosine phosphorylation of proteins after activation of platelets with thrombin depends on intact glycoprotein Ib .
7524356	0	tyrosine	60,68	thrombin	23,31	tyrosine	thrombin	CHEBI:18186	2147	Chemical	Gene	phosphorylation|amod|START_ENTITY role|nmod|phosphorylation signaling|dep|role signaling|nmod|END_ENTITY	Mitogenic signaling of thrombin in mesangial cells : role of tyrosine phosphorylation .
7681669	0	tyrosine	81,89	thrombin	46,54	tyrosine	thrombin	CHEBI:18186	2147	Chemical	Gene	phosphorylation|compound|START_ENTITY inhibits|parataxis|phosphorylation inhibits|dobj|END_ENTITY	Elevation of cAMP in human platelets inhibits thrombin - but not collagen-induced tyrosine phosphorylation .
7692843	0	tyrosine	34,42	thrombin	76,84	tyrosine	thrombin	CHEBI:18186	2147	Chemical	Gene	affinity|nmod|START_ENTITY increased|nsubjpass|affinity increased|nmod|stimulation stimulation|compound|END_ENTITY	Substrate affinity of the protein tyrosine kinase pp60c-src is increased on thrombin stimulation of human platelets .
7781604	0	tyrosine	54,62	thrombin	98,106	tyrosine	thrombin	CHEBI:18186	2147	Chemical	Gene	phosphatase|compound|START_ENTITY phosphorylation|nmod|phosphatase coupled|nsubjpass|phosphorylation coupled|xcomp|platelet platelet|dobj|receptor receptor|compound|END_ENTITY	Tyrosine phosphorylation of an SH2-containing protein tyrosine phosphatase is coupled to platelet thrombin receptor via a pertussis toxin-sensitive heterotrimeric G-protein .
7878644	0	tyrosine	4,12	thrombin	152,160	tyrosine	thrombin	CHEBI:18186	2147	Chemical	Gene	inhibitors|amod|START_ENTITY inhibit|nsubj|inhibitors inhibit|nmod|platelets platelets|acl|stimulated stimulated|nmod|END_ENTITY	The tyrosine kinase inhibitors , genistein and methyl_2 ,5 - dihydroxycinnamate , inhibit the release of -LRB- 3H -RRB- arachidonate from human platelets stimulated by thrombin or collagen .
8780738	0	tyrosine	29,37	thrombin	81,89	tyrosine	thrombin	CHEBI:18186	2147	Chemical	Gene	kinases|amod|START_ENTITY mobilization|nmod|kinases stimulated|nsubj|mobilization stimulated|nmod|END_ENTITY	Differential mobilization of tyrosine kinases in human platelets stimulated with thrombin or thrombin_receptor_agonist_peptide .
9753458	0	tyrosine	16,24	thrombin	87,95	tyrosine	thrombin	CHEBI:18186	2147	Chemical	Gene	Substitution|nmod|START_ENTITY fibrinopeptide|nsubj|Substitution fibrinopeptide|nmod|cleavage cleavage|compound|END_ENTITY	Substitution of tyrosine for phenylalanine in fibrinopeptide A results in preferential thrombin cleavage of fibrinopeptide B from fibrinogen .
7534285	0	tyrosine	45,53	thrombopoietin	18,32	tyrosine	thrombopoietin	CHEBI:18186	21832(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	The c-Mpl_ligand -LRB- thrombopoietin -RRB- stimulates tyrosine phosphorylation of Jak2 , Shc , and c-Mpl .
7511888	0	tyrosine	37,45	thyroglobulin	64,77	tyrosine	thyroglobulin	CHEBI:18186	7038	Chemical	Gene	residues|compound|START_ENTITY residues|nmod|END_ENTITY	-LSB- Chemical iodination of hormonogenic tyrosine residues of human thyroglobulin is critical for the production of anti-thyroglobulin autoantibody and for the induction of experimental autoimmune_thyroiditis in mice -RSB- .
10430078	0	tyrosine	14,22	tie-1	0,5	tyrosine	tie-1	CHEBI:18186	7075	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	tie-1 protein tyrosine kinase : a novel independent prognostic marker for gastric_cancer .
19230825	0	tyrosine	56,64	tie-1	72,77	tyrosine	tie-1	CHEBI:18186	21846(Tax:10090)	Chemical	Gene	using|dobj|START_ENTITY over-expression|acl|using kinase|nsubj|over-expression kinase|dobj|leads leads|amod|END_ENTITY	Endothelial endothelin-1 over-expression using receptor tyrosine kinase tie-1 promoter leads to more severe vascular permeability and blood brain barrier breakdown after transient middle_cerebral_artery_occlusion .
9603430	0	tyrosine	92,100	tie-1	46,51	tyrosine	tie-1	CHEBI:18186	30746(Tax:7955)	Chemical	Gene	kinases|compound|START_ENTITY kinases|amod|END_ENTITY	Isolation of the zebrafish homologues for the tie-1 and tie-2 endothelium-specific receptor tyrosine kinases .
8187650	0	tyrosine	60,68	tie-2	14,19	tyrosine	tie-2	CHEBI:18186	21687(Tax:10090)	Chemical	Gene	kinases|compound|START_ENTITY family|nmod|kinases member|nmod|family Expression|appos|member Expression|nmod|END_ENTITY	Expression of tie-2 , a member of a novel family of receptor tyrosine kinases , in the endothelial cell lineage .
9837743	0	tyrosine	65,73	tie-2	50,55	tyrosine	tie-2	CHEBI:18186	7010	Chemical	Gene	START_ENTITY|nsubj|characterization characterization|nmod|receptor receptor|amod|END_ENTITY	Cloning and partial characterization of the human tie-2 receptor tyrosine kinase gene promoter .
8217221	0	tyrosine	25,33	tie2	0,4	tyrosine	tie2	CHEBI:18186	21687(Tax:10090)	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|advmod|END_ENTITY	tie2 , a putative protein tyrosine kinase from a new class of cell surface receptor .
8108143	0	tyrosine	38,46	tif	55,58	tyrosine	tif	CHEBI:18186	7301	Chemical	Gene	kinase|compound|START_ENTITY kinase|appos|END_ENTITY	Molecular cloning of a novel receptor tyrosine kinase , tif , highly expressed in human ovary and testis .
8667655	0	tyrosine	31,39	tif	47,50	tyrosine	tif	CHEBI:18186	7301	Chemical	Gene	START_ENTITY|ccomp|regulated regulated|nsubjpass|END_ENTITY	Expression of receptor protein tyrosine kinase tif is regulated during leukemia cell differentiation .
18234883	0	tyrosine	75,83	transient_receptor_potential_vanilloid_4	15,55	tyrosine	transient receptor potential vanilloid 4	CHEBI:18186	63873(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Interaction Interaction|nmod|END_ENTITY	Interaction of transient_receptor_potential_vanilloid_4 , integrin , and SRC tyrosine kinase in mechanical_hyperalgesia .
1313574	0	tyrosine	62,70	transmembrane_receptor	39,61	tyrosine	transmembrane receptor	CHEBI:18186	8829	Chemical	Gene	kinase|amod|START_ENTITY END_ENTITY|dobj|kinase	K-sam gene encodes secreted as well as transmembrane_receptor tyrosine kinase .
10495355	0	tyrosine	103,111	trk	99,102	tyrosine	trk	CHEBI:18186	4914	Chemical	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Role of neurotrophin-trk interactions in oncology : the anti-tumor efficacy of potent and selective trk tyrosine kinase inhibitors in pre-clinical tumor models .
10717245	0	tyrosine	64,72	trk	101,104	tyrosine	trk	CHEBI:18186	4914	Chemical	Gene	receptor|amod|START_ENTITY receptor|nmod|oncogene oncogene|compound|END_ENTITY	Ribosomal_protein_L7a gene is up-regulated but not fused to the tyrosine kinase receptor as chimeric trk oncogene in human colorectal_carcinoma .
1312698	0	tyrosine	38,46	trk	78,81	tyrosine	trk	CHEBI:18186	59109(Tax:10116)	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|family family|compound|END_ENTITY	K252a is a selective inhibitor of the tyrosine protein kinase activity of the trk family of oncogenes and neurotrophin receptors .
1380963	0	tyrosine	110,118	trk	106,109	tyrosine	trk	CHEBI:18186	59109(Tax:10116)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Nerve_growth_factor promotes the activation of phosphatidylinositol 3-kinase and its association with the trk tyrosine kinase .
1384575	0	tyrosine	26,34	trk	22,25	tyrosine	trk	CHEBI:18186	59109(Tax:10116)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Overexpression of the trk tyrosine kinase rapidly accelerates nerve growth factor-induced differentiation .
1629741	0	tyrosine	56,64	trk	52,55	tyrosine	trk	CHEBI:18186	59109(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	K-252b selectively potentiates cellular actions and trk tyrosine phosphorylation mediated by neurotrophin-3 .
1649007	0	tyrosine	8,16	trk	4,7	tyrosine	trk	CHEBI:18186	18211(Tax:10090)	Chemical	Gene	kinase|amod|START_ENTITY kinase|amod|END_ENTITY	The trk tyrosine protein kinase mediates the mitogenic properties of nerve_growth_factor and neurotrophin-3 .
1653651	0	tyrosine	40,48	trk	26,29	tyrosine	trk	CHEBI:18186	4914	Chemical	Gene	kinases|amod|START_ENTITY family|nmod|kinases family|compound|END_ENTITY	trkC , a new member of the trk family of tyrosine protein kinases , is a receptor for neurotrophin-3 .
1712104	0	tyrosine	39,47	trk	147,150	tyrosine	trk	CHEBI:18186	59109(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|protooncogene protooncogene|amod|phospholipase_C-gamma_1 phospholipase_C-gamma_1|nmod|activity activity|acl|associated associated|nmod|product product|nmod|END_ENTITY	Nerve growth factor rapidly stimulates tyrosine phosphorylation of phospholipase_C-gamma_1 by a kinase activity associated with the product of the trk protooncogene .
1730579	0	tyrosine	63,71	trk	44,47	tyrosine	trk	CHEBI:18186	59109(Tax:10116)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	K-252a inhibits nerve growth factor-induced trk proto-oncogene tyrosine phosphorylation and kinase activity .
1837350	0	tyrosine	49,57	trk	85,88	tyrosine	trk	CHEBI:18186	4914	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|oncogene oncogene|compound|END_ENTITY	Mutational analysis of conserved residues in the tyrosine kinase domain of the human trk oncogene .
23662477	0	tyrosine	108,116	trk	127,130	tyrosine	trk	CHEBI:18186	59109(Tax:10116)	Chemical	Gene	kinase|amod|START_ENTITY kinase|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Metabolic effects of ganglioside_GM1 on PC12 cells at oxidative stress depend on modulation of activity of tyrosine kinase of trk receptor -RSB- .
7551570	0	tyrosine	23,31	trk	19,22	tyrosine	trk	CHEBI:18186	59109(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	NGF binding to the trk tyrosine kinase receptor requires the extracellular immunoglobulin-like domains .
8144877	0	tyrosine	29,37	trk	25,28	tyrosine	trk	CHEBI:18186	4914	Chemical	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of functional trk tyrosine kinase receptors after T cell activation .
8428057	0	tyrosine	59,67	trk	45,48	tyrosine	trk	CHEBI:18186	4914	Chemical	Gene	family|nmod|START_ENTITY family|compound|END_ENTITY	Role and expression of neurotrophins and the trk family of tyrosine kinase receptors in neural growth and rescue after injury .
8895522	0	tyrosine	28,36	trk	64,67	tyrosine	trk	CHEBI:18186	4914	Chemical	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Oncogenic activation of the tyrosine kinase domain of the human trk proto-oncogene by fusion to a cell adhesion molecule .
10741463	1	tyrosine	154,162	trkA	385,389	tyrosine	trkA	CHEBI:18186	59109(Tax:10116)	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|advcl|modulates modulates|dobj|activity activity|compound|END_ENTITY	High-affinity tyrosine kinase A -LRB- trkA -RRB- neurotrophin receptors on neurons and nonneuronal cells elicit differentiation or survival functions in response to nerve growth factor -LRB- NGF -RRB- , whereas the low-affinity neurotrophin -LRB- p75 -RRB- receptor modulates trkA activity or can independently cause apoptosis or NFkappaB-mediated survival functions .
15916429	1	tyrosine	150,158	trkA	145,149	tyrosine	trkA	CHEBI:18186	4914	Chemical	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Elucidating the stereochemical requirements of the 3 ' - sugar_alcohol on trkA tyrosine kinase activity .
19749791	0	tyrosine	52,60	trkA	47,51	tyrosine	trkA	CHEBI:18186	4914	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Repression of SHP-1 expression by p53 leads to trkA tyrosine phosphorylation and suppression of breast_cancer cell proliferation .
9230082	0	tyrosine	17,25	trkA	45,49	tyrosine	trkA	CHEBI:18186	59109(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Rapid retrograde tyrosine phosphorylation of trkA and other proteins in rat sympathetic neurons in compartmented cultures .
9448714	0	tyrosine	17,25	trkA	12,16	tyrosine	trkA	CHEBI:18186	4914	Chemical	Gene	START_ENTITY|nsubj|Kinetics Kinetics|nmod|END_ENTITY	Kinetics of trkA tyrosine kinase activity and inhibition by K-252a .
1488128	0	tyrosine	36,44	trkB	61,65	tyrosine	trkB	CHEBI:18186	25054(Tax:10116)	Chemical	Gene	messenger|amod|START_ENTITY messenger|compound|END_ENTITY	Cortical transynaptic activation of tyrosine kinase receptor trkB messenger RNA expression in rat hippocampus .
1656363	0	tyrosine	107,115	trkB	102,106	tyrosine	trkB	CHEBI:18186	4915	Chemical	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	A novel modular mosaic of cell adhesion motifs in the extracellular domains of the neurogenic trk and trkB tyrosine kinase receptors .
2160854	0	tyrosine	9,17	trkB	4,8	tyrosine	trkB	CHEBI:18186	18212(Tax:10090)	Chemical	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain .
2555172	0	tyrosine	14,22	trkB	0,4	tyrosine	trkB	CHEBI:18186	18212(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY expressed|nsubj|receptor expressed|ccomp|END_ENTITY	trkB , a novel tyrosine protein kinase receptor expressed during mouse neural development .
8388086	0	tyrosine	51,59	trkB	37,41	tyrosine	trkB	CHEBI:18186	25054(Tax:10116)	Chemical	Gene	RNA|compound|START_ENTITY RNA|amod|END_ENTITY	Regulation of neurotrophin and trkA , trkB and trkC tyrosine kinase receptor messenger RNA expression in kindling .
19577549	0	tyrosine	75,83	tryptophan_hydroxylase	114,136	tyrosine	tryptophan hydroxylase	CHEBI:18186	216343(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Glucocorticoid status affects antidepressant regulation of locus coeruleus tyrosine hydroxylase and dorsal raph tryptophan_hydroxylase gene expression .
24859	0	tyrosine	73,81	tryptophan_pyrrolase	48,68	tyrosine	tryptophan pyrrolase	CHEBI:18186	64206(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|nmod|END_ENTITY	The effect of stress on the activity of hepatic tryptophan_pyrrolase , of tyrosine aminotransferase in various organs and on the level of tryptophan in the liver and plasma of rats .
7543512	0	tyrosine	18,26	tyk2	46,50	tyrosine	tyk2	CHEBI:18186	7297	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 and the differential assembly of STAT1 alpha and STAT3 complexes in human T cells and monocytes .
7723626	0	tyrosine	76,84	tyro3	37,42	tyrosine	tyro3	CHEBI:18186	22174(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY END_ENTITY|appos|kinase	Isolation and expression analysis of tyro3 , a murine growth_factor_receptor tyrosine kinase preferentially expressed in adult brain .
119492	0	tyrosine	33,41	tyrosinase	72,82	tyrosine	tyrosinase	CHEBI:18186	100008753(Tax:9986)	Chemical	Gene	analysis|nmod|START_ENTITY analysis|nmod|END_ENTITY	A rapid quantitative analysis of tyrosine and its oxidation products by tyrosinase .
1476926	2	tyrosine	243,251	tyrosinase	330,340	tyrosine	tyrosinase	CHEBI:18186	7299	Chemical	Gene	test|compound|START_ENTITY demonstrated|nsubj|test demonstrated|dobj|presence presence|nmod|activity activity|amod|END_ENTITY	An electron microscopic tyrosine incubation test and a DOPA reaction test clearly demonstrated the presence of tyrosinase activity in the patient 's hypopigmented_skin .
16403014	0	tyrosine	37,45	tyrosinase	2,12	tyrosine	tyrosinase	CHEBI:18186	7299	Chemical	Gene	hydroxylase/dopa|compound|START_ENTITY END_ENTITY|nmod|hydroxylase/dopa	A tyrosinase with an abnormally high tyrosine hydroxylase/dopa oxidase ratio .
18975953	0	tyrosine	71,79	tyrosinase	91,101	tyrosine	tyrosinase	CHEBI:18186	7299	Chemical	Gene	moiety|amod|START_ENTITY moiety|nmod|detection detection|amod|END_ENTITY	Synthesis of a new water-soluble oligo -LRB- phenylenevinylene -RRB- containing a tyrosine moiety for tyrosinase activity detection .
22187676	0	tyrosine	53,61	tyrosinase	25,35	tyrosine	tyrosinase	CHEBI:18186	7299	Chemical	Gene	inactivation|nmod|START_ENTITY inactivation|nmod|END_ENTITY	Indirect inactivation of tyrosinase in its action on tyrosine .
26589783	0	tyrosine	75,83	tyrosinase	4,14	tyrosine	tyrosinase	D014443	7299	Chemical	Gene	residues|amod|START_ENTITY role|nmod|residues insights|nmod|role decapeptide|dep|insights decapeptide|amod|END_ENTITY	New tyrosinase inhibitory decapeptide : Molecular insights into the role of tyrosine residues .
3089286	0	tyrosine	33,41	tyrosinase	87,97	tyrosine	tyrosinase	CHEBI:18186	7299	Chemical	Gene	hydroxylation|nmod|START_ENTITY Optimization|nmod|hydroxylation peptides|nsubj|Optimization peptides|nmod|END_ENTITY	Optimization of hydroxylation of tyrosine and tyrosine-containing peptides by mushroom tyrosinase .
3109385	0	tyrosine	24,32	tyrosinase	90,100	tyrosine	tyrosinase	CHEBI:18186	7299	Chemical	Gene	dopa|compound|START_ENTITY analogues|nmod|dopa influence|nsubj|analogues influence|dobj|activity activity|compound|END_ENTITY	Phosphonic analogues of tyrosine and 3,4-dihydroxyphenylalanine -LRB- dopa -RRB- influence mushroom tyrosinase activity .
3927896	0	tyrosine	40,48	tyrosinase	72,82	tyrosine	tyrosinase	CHEBI:18186	7299	Chemical	Gene	oxidation|amod|START_ENTITY kinetics|nmod|oxidation ions|nmod|kinetics Effect|nmod|ions catalysed|nsubj|Effect catalysed|nmod|END_ENTITY	Effect of metal ions on the kinetics of tyrosine oxidation catalysed by tyrosinase .
410043	0	tyrosine	17,25	tyrosinase	59,69	tyrosine	tyrosinase	CHEBI:18186	7299	Chemical	Gene	Hydroxylation|nmod|START_ENTITY END_ENTITY|nsubj|Hydroxylation	Hydroxylation of tyrosine by plant peroxidase and mushroom tyrosinase , with and without hydrazine , to retard the oxidation of dopa .
4987505	0	tyrosine	77,85	tyrosinase	39,49	tyrosine	tyrosinase	CHEBI:18186	7299	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of peroxidase vs. the role of tyrosinase in enzymatic conversion of tyrosine to melanin in melanocytes , mast cells and eosinophils .
6067667	0	tyrosine	29,37	tyrosinase	62,72	tyrosine	tyrosinase	CHEBI:18186	7299	Chemical	Gene	residues|amod|START_ENTITY reactivities|nmod|residues reactivities|acl|END_ENTITY	Differential reactivities of tyrosine residues of proteins to tyrosinase .
6433900	0	tyrosine	13,21	tyrosinase	46,56	tyrosine	tyrosinase	CHEBI:18186	280951(Tax:9913)	Chemical	Gene	residues|amod|START_ENTITY Oxidation|nmod|residues Oxidation|nmod|proteins proteins|nmod|END_ENTITY	Oxidation of tyrosine residues in proteins by tyrosinase .
6792293	0	tyrosine	125,133	tyrosinase	111,121	tyrosine	tyrosinase	CHEBI:18186	22173(Tax:10090)	Chemical	Gene	chromatography|amod|START_ENTITY END_ENTITY|nmod|chromatography	Characterization of structural properties for morphological differentiation of melanosomes : I. Purification of tyrosinase by tyrosine affinity chromatography and its characterization in B16 and Harding_Passey melanomas .
8660589	0	tyrosine	10,18	tyrosinase	45,55	tyrosine	tyrosinase	CHEBI:18186	7299	Chemical	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Assay for tyrosine hydroxylation activity of tyrosinase from betalain-forming plants and cell cultures .
9843160	0	tyrosine	77,85	tyrosinase	29,39	tyrosine	tyrosinase	CHEBI:18186	7299	Chemical	Gene	hydroxylase|amod|START_ENTITY modifies|dobj|hydroxylase modifies|nmod|presence presence|nmod|END_ENTITY	Dopamine , in the presence of tyrosinase , covalently modifies and inactivates tyrosine hydroxylase .
24069562	0	tyrosine	81,89	urocortin	32,41	tyrosine	urocortin	CHEBI:18186	7349	Chemical	Gene	pathway|amod|START_ENTITY activation|nmod|pathway mediated|nmod|activation mediated|nsubjpass|effects effects|nmod|END_ENTITY	The cardioprotective effects of urocortin are mediated via activation of the Src tyrosine kinase-STAT3 pathway .
7593300	0	tyrosine	42,50	v-ABL	28,33	tyrosine	v-ABL	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Suppression of apoptosis by v-ABL protein tyrosine kinase is associated with nuclear translocation and activation of protein kinase C in an interleukin-3-dependent haemopoietic cell line .
12476303	0	tyrosine	45,53	v-Abl	39,44	tyrosine	v-Abl	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Transforming pathways activated by the v-Abl tyrosine kinase .
8702661	0	tyrosine	34,42	v-Abl	28,33	tyrosine	v-Abl	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Cells arrested in G1 by the v-Abl tyrosine kinase do not express cyclin_A despite the hyperphosphorylation of RB .
9119229	0	tyrosine	46,54	v-Abl	40,45	tyrosine	v-Abl	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Induction of c-myc transcription by the v-Abl tyrosine kinase requires Ras , Raf1 , and cyclin-dependent kinases .
3122023	0	tyrosine	24,32	v-abl	50,55	tyrosine	v-abl	CHEBI:18186	25	Chemical	Gene	region|amod|START_ENTITY region|nmod|END_ENTITY	Recombinants within the tyrosine kinase region of v-abl and v-src identify a v-abl segment that confers lymphoid specificity .
7926758	0	tyrosine	10,18	v-abl	4,9	tyrosine	v-abl	CHEBI:18186	25	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	The v-abl tyrosine kinase negatively regulates NF-kappa_B / Rel factors and blocks kappa gene transcription in pre-B lymphocytes .
8157674	0	tyrosine	70,78	valosin-containing_protein	32,58	tyrosine	valosin-containing protein	CHEBI:18186	269523(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|characterization characterization|nmod|END_ENTITY	Biochemical characterization of valosin-containing_protein , a protein tyrosine kinase substrate in hematopoietic cells .
22815286	0	tyrosine	56,64	vascular_endothelial-cadherin	26,55	tyrosine	vascular endothelial-cadherin	CHEBI:18186	12562(Tax:10090)	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Endothelial CD47 promotes vascular_endothelial-cadherin tyrosine phosphorylation and participates in T cell recruitment at sites of inflammation in vivo .
16891393	0	tyrosine	20,28	vascular_endothelial_cadherin	48,77	tyrosine	vascular endothelial cadherin	CHEBI:18186	1003	Chemical	Gene	START_ENTITY|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	TNF-alpha increases tyrosine phosphorylation of vascular_endothelial_cadherin and opens the paracellular pathway through fyn activation in human lung endothelia .
17785844	0	tyrosine	71,79	vascular_endothelial_cadherin	41,70	tyrosine	vascular endothelial cadherin	CHEBI:18186	1003	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	ICAM-1-mediated , Src - and Pyk2-dependent vascular_endothelial_cadherin tyrosine phosphorylation is required for leukocyte transendothelial migration .
22659162	0	tyrosine	115,123	vascular_endothelial_cadherin	85,114	tyrosine	vascular endothelial cadherin	CHEBI:18186	1003	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Atorvastatin preserves the integrity of endothelial adherens junctions by inhibiting vascular_endothelial_cadherin tyrosine phosphorylation .
22833667	0	tyrosine	23,31	vascular_endothelial_cadherin	51,80	tyrosine	vascular endothelial cadherin	CHEBI:18186	1003	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Integrin a2b1 mediates tyrosine phosphorylation of vascular_endothelial_cadherin induced by invasive breast_cancer cells .
25027642	0	tyrosine	135,143	vascular_endothelial_cadherin	105,134	tyrosine	vascular endothelial cadherin	CHEBI:18186	1003	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Disruption of endothelial adherens junctions by high glucose is mediated by protein kinase C-b-dependent vascular_endothelial_cadherin tyrosine phosphorylation .
25776576	0	tyrosine	135,143	vascular_endothelial_cadherin	105,134	tyrosine	vascular endothelial cadherin	CHEBI:18186	1003	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Disruption of endothelial adherens junctions by high glucose is mediated by protein kinase C-b-dependent vascular_endothelial_cadherin tyrosine phosphorylation .
25927959	0	tyrosine	135,143	vascular_endothelial_cadherin	105,134	tyrosine	vascular endothelial cadherin	D014443	1003	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Disruption of endothelial adherens junctions by high glucose is mediated by protein kinase C-b-dependent vascular_endothelial_cadherin tyrosine phosphorylation .
10786682	0	tyrosine	94,102	vascular_endothelial_growth_factor	50,84	tyrosine	vascular endothelial growth factor	CHEBI:18186	22339(Tax:10090)	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	PTK787/ZK _ 222584 , a novel and potent inhibitor of vascular_endothelial_growth_factor receptor tyrosine kinases , impairs vascular_endothelial_growth_factor-induced responses and tumor growth after oral administration .
10987292	0	tyrosine	97,105	vascular_endothelial_growth_factor	53,87	tyrosine	vascular endothelial growth factor	CHEBI:18186	22339(Tax:10090)	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Effects of PTK787/ZK _ 222584 , a specific inhibitor of vascular_endothelial_growth_factor receptor tyrosine kinases , on primary_tumor , metastasis , vessel density , and blood flow in a murine renal_cell_carcinoma model .
12208756	0	tyrosine	48,56	vascular_endothelial_growth_factor	4,38	tyrosine	vascular endothelial growth factor	CHEBI:18186	7422	Chemical	Gene	START_ENTITY|nsubj|receptor receptor|compound|END_ENTITY	The vascular_endothelial_growth_factor receptor tyrosine kinase inhibitor PTK787/ZK222584 inhibits growth and migration of multiple_myeloma cells in the bone marrow microenvironment .
12538485	0	tyrosine	47,55	vascular_endothelial_growth_factor	83,117	tyrosine	vascular endothelial growth factor	CHEBI:18186	7422	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|dobj|END_ENTITY	In vivo antitumor activity of SU11248 , a novel tyrosine kinase inhibitor targeting vascular_endothelial_growth_factor and platelet-derived growth factor receptors : determination of a pharmacokinetic/pharmacodynamic relationship .
14517187	0	tyrosine	186,194	vascular_endothelial_growth_factor	142,176	tyrosine	vascular endothelial growth factor	CHEBI:18186	7422	Chemical	Gene	kinases|amod|START_ENTITY kinases|compound|END_ENTITY	Dynamic contrast-enhanced magnetic resonance imaging as a biomarker for the pharmacological response of PTK787/ZK _ 222584 , an inhibitor of the vascular_endothelial_growth_factor receptor tyrosine kinases , in patients with advanced colorectal_cancer and liver metastases : results from two phase I studies .
14612527	0	tyrosine	102,110	vascular_endothelial_growth_factor	56,90	tyrosine	vascular endothelial growth factor	CHEBI:18186	7422	Chemical	Gene	inhibitor|amod|START_ENTITY END_ENTITY|dobj|inhibitor	Pharmacological characterization of CP-547 ,632 , a novel vascular_endothelial_growth_factor receptor-2 tyrosine kinase inhibitor for cancer therapy .
15271251	0	tyrosine	77,85	vascular_endothelial_growth_factor	33,67	tyrosine	vascular endothelial growth factor	CHEBI:18186	83785(Tax:10116)	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	PTK787/ZK222584 , an inhibitor of vascular_endothelial_growth_factor receptor tyrosine kinases , decreases glioma growth and vascularization .
15367698	0	tyrosine	54,62	vascular_endothelial_growth_factor	10,44	tyrosine	vascular endothelial growth factor	CHEBI:18186	7422	Chemical	Gene	inhibitor|compound|START_ENTITY inhibitor|compound|END_ENTITY	ZD6474 , a vascular_endothelial_growth_factor receptor tyrosine kinase inhibitor with additional activity against epidermal_growth_factor receptor tyrosine kinase , inhibits orthotopic growth and angiogenesis of gastric_cancer .
15634658	0	tyrosine	79,87	vascular_endothelial_growth_factor	33,67	tyrosine	vascular endothelial growth factor	CHEBI:18186	7422	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	KRN633 : A selective inhibitor of vascular_endothelial_growth_factor receptor-2 tyrosine kinase that suppresses tumor angiogenesis and growth .
16459176	0	tyrosine	65,73	vascular_endothelial_growth_factor	21,55	tyrosine	vascular endothelial growth factor	CHEBI:18186	7422	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|receptor receptor|compound|END_ENTITY	The emerging role of vascular_endothelial_growth_factor receptor tyrosine kinase inhibitors .
16616080	0	tyrosine	74,82	vascular_endothelial_growth_factor	18,52	tyrosine	vascular endothelial growth factor	CHEBI:18186	7422	Chemical	Gene	secretion|amod|START_ENTITY secretion|amod|END_ENTITY	Hypoxia regulates vascular_endothelial_growth_factor and soluble fms-like tyrosine kinase-1 secretion by human oviductal epithelial cells and stromal fibroblasts .
16982756	0	tyrosine	81,89	vascular_endothelial_growth_factor	37,71	tyrosine	vascular endothelial growth factor	CHEBI:18186	7422	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	KRN951 , a highly potent inhibitor of vascular_endothelial_growth_factor receptor tyrosine kinases , has antitumor activities and affects functional vascular properties .
17071533	0	tyrosine	84,92	vascular_endothelial_growth_factor	28,62	tyrosine	vascular endothelial growth factor	CHEBI:18186	7422	Chemical	Gene	secretion|amod|START_ENTITY secretion|amod|END_ENTITY	Interleukin-1beta regulates vascular_endothelial_growth_factor and soluble fms-like tyrosine kinase-1 secretion by human oviductal epithelial cells and stromal fibroblasts .
17121916	0	tyrosine	98,106	vascular_endothelial_growth_factor	54,88	tyrosine	vascular endothelial growth factor	CHEBI:18186	7422	Chemical	Gene	kinases|amod|START_ENTITY kinases|compound|END_ENTITY	Concomitant inhibition of epidermal growth factor and vascular_endothelial_growth_factor receptor tyrosine kinases reduces growth and metastasis of human salivary adenoid_cystic_carcinoma in an orthotopic nude mouse model .
17287067	0	tyrosine	99,107	vascular_endothelial_growth_factor	43,77	tyrosine	vascular endothelial growth factor	CHEBI:18186	7422	Chemical	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	Interleukin-13 stimulates the secretion of vascular_endothelial_growth_factor and soluble fms-like tyrosine kinase-1 by human oviductal epithelial cells .
17441906	0	tyrosine	67,75	vascular_endothelial_growth_factor	23,57	tyrosine	vascular endothelial growth factor	CHEBI:18186	7422	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	The discovery of novel vascular_endothelial_growth_factor receptor tyrosine kinases inhibitors : pharmacophore modeling , virtual screening and docking studies .
18398152	0	tyrosine	108,116	vascular_endothelial_growth_factor	73,107	tyrosine	vascular endothelial growth factor	CHEBI:18186	7422	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	Phase I and pharmacokinetic study of daily oral AZD2171 , an inhibitor of vascular_endothelial_growth_factor tyrosine kinases , in combination with carboplatin and paclitaxel in patients with advanced non-small-cell_lung_cancer : the National Cancer Institute of Canada clinical trials group .
19091548	0	tyrosine	112,120	vascular_endothelial_growth_factor	77,111	tyrosine	vascular endothelial growth factor	CHEBI:18186	7422	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	A phase I and pharmacokinetic study of daily oral cediranib , an inhibitor of vascular_endothelial_growth_factor tyrosine kinases , in combination with cisplatin and gemcitabine in patients with advanced non-small_cell_lung_cancer : a study of the National Cancer Institute of Canada Clinical Trials Group .
20197639	0	tyrosine	81,89	vascular_endothelial_growth_factor	35,69	tyrosine	vascular endothelial growth factor	CHEBI:18186	22339(Tax:10090)	Chemical	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Effects of KRN633 , an inhibitor of vascular_endothelial_growth_factor receptor-2 tyrosine kinase , on vascular development of placenta and fetus of mid-pregnancy in mice .
20380868	0	tyrosine	56,64	vascular_endothelial_growth_factor	12,46	tyrosine	vascular endothelial growth factor	CHEBI:18186	7422	Chemical	Gene	inhibitor|compound|START_ENTITY inhibitor|compound|END_ENTITY	AEE788 is a vascular_endothelial_growth_factor receptor tyrosine kinase inhibitor with antiproliferative and proapoptotic effects in acute_myeloid_leukemia .
20570929	0	tyrosine	48,56	vascular_endothelial_growth_factor	4,38	tyrosine	vascular endothelial growth factor	CHEBI:18186	22339(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|receptor receptor|compound|END_ENTITY	The vascular_endothelial_growth_factor receptor tyrosine kinase inhibitors vatalanib and pazopanib potently induce apoptosis in chronic_lymphocytic_leukemia cells in vitro and in vivo .
21443688	0	tyrosine	92,100	vascular_endothelial_growth_factor	46,80	tyrosine	vascular endothelial growth factor	CHEBI:18186	7422	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	YN968D1 is a novel and selective inhibitor of vascular_endothelial_growth_factor receptor-2 tyrosine kinase with potent activity in vitro and in vivo .
22460837	0	tyrosine	66,74	vascular_endothelial_growth_factor	24,58	tyrosine	vascular endothelial growth factor	CHEBI:18186	7422	Chemical	Gene	START_ENTITY|nsubj|efficacy efficacy|nmod|END_ENTITY	Comparative efficacy of vascular_endothelial_growth_factor -LRB- VEGF -RRB- tyrosine kinase inhibitor -LRB- TKI -RRB- and mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitor as second-line therapy in patients with metastatic_renal_cell_carcinoma after the failure of first-line VEGF TKI .
23780833	0	tyrosine	68,76	vascular_endothelial_growth_factor	24,58	tyrosine	vascular endothelial growth factor	CHEBI:18186	22339(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	KRN633 , an inhibitor of vascular_endothelial_growth_factor receptor tyrosine kinase , induces intrauterine_growth_restriction in mice .
24182420	0	tyrosine	113,121	vascular_endothelial_growth_factor	69,103	tyrosine	vascular endothelial growth factor	CHEBI:18186	7422	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Risk of gastrointestinal_perforation in cancer patients treated with vascular_endothelial_growth_factor receptor tyrosine kinase inhibitors : a systematic review and meta-analysis .
24661224	0	tyrosine	97,105	vascular_endothelial_growth_factor	62,96	tyrosine	vascular endothelial growth factor	CHEBI:18186	7422	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Congestive_heart_failure risk in cancer patients treated with vascular_endothelial_growth_factor tyrosine kinase inhibitors : a systematic review and meta-analysis of 36 clinical trials .
25336977	0	tyrosine	82,90	vascular_endothelial_growth_factor	38,72	tyrosine	vascular endothelial growth factor	CHEBI:18186	7422	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Risk of treatment-related deaths with vascular_endothelial_growth_factor receptor tyrosine kinase inhibitors : a meta-analysis of 41 randomized controlled trials .
25451848	0	tyrosine	89,97	vascular_endothelial_growth_factor	45,79	tyrosine	vascular endothelial growth factor	CHEBI:18186	22339(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|compound|END_ENTITY	Treatment of newborn mice with inhibitors of vascular_endothelial_growth_factor receptor tyrosine kinase induces abnormal retinal_vascular patterning .
19245910	0	tyrosine	55,63	vascular_endothelial_growth_factor_receptor	11,54	tyrosine	vascular endothelial growth factor receptor	CHEBI:18186	3791	Chemical	Gene	inhibitor|compound|START_ENTITY inhibitor|compound|END_ENTITY	A specific vascular_endothelial_growth_factor_receptor tyrosine kinase inhibitor enhances the antiproliferative effect of trastuzumab in human epidermal_growth_factor_receptor_2 overexpressing breast_cancer cell lines .
21691074	0	tyrosine	84,92	vascular_endothelial_growth_factor_receptor	40,83	tyrosine	vascular endothelial growth factor receptor	CHEBI:18186	3791	Chemical	Gene	kinases|compound|START_ENTITY kinases|compound|END_ENTITY	SKLB610 : a novel potential inhibitor of vascular_endothelial_growth_factor_receptor tyrosine kinases inhibits angiogenesis and tumor growth in vivo .
22237457	0	tyrosine	67,75	vascular_endothelial_growth_factor_receptor	23,66	tyrosine	vascular endothelial growth factor receptor	CHEBI:18186	3791	Chemical	Gene	START_ENTITY|nsubj|Efficacy Efficacy|nmod|END_ENTITY	Efficacy and safety of vascular_endothelial_growth_factor_receptor tyrosine kinase inhibitors in patients with metastatic_renal_cell_carcinoma and poor risk features .
23317774	0	tyrosine	78,86	vascular_endothelial_growth_factor_receptor	34,77	tyrosine	vascular endothelial growth factor receptor	CHEBI:18186	3791	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Venous thromboembolic_events with vascular_endothelial_growth_factor_receptor tyrosine kinase inhibitors : a systematic review and meta-analysis of randomized clinical trials .
24970912	0	tyrosine	2,10	vascular_endothelial_growth_factor_receptor	80,123	tyrosine	vascular endothelial growth factor receptor	CHEBI:18186	3791	Chemical	Gene	kinase|nsubj|START_ENTITY kinase|advmod|END_ENTITY	A tyrosine kinase inhibitor-based high-affinity PET radiopharmaceutical targets vascular_endothelial_growth_factor_receptor .
25523486	0	tyrosine	64,72	vascular_endothelial_growth_factor_receptor	20,63	tyrosine	vascular endothelial growth factor receptor	CHEBI:18186	3791	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Hepatotoxicity with vascular_endothelial_growth_factor_receptor tyrosine kinase inhibitors : A meta-analysis of randomized clinical trials .
25900071	0	tyrosine	57,65	vascular_endothelial_growth_factor_receptor	13,56	tyrosine	vascular endothelial growth factor receptor	D014443	3791	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|amod|END_ENTITY	Fatigue with vascular_endothelial_growth_factor_receptor tyrosine kinase inhibitors and mammalian_target_of_rapamycin inhibitors in patients with renal_cell_carcinoma -LRB- RCC -RRB- and other malignancies : A meta-analysis of randomized clinical trials .
16709927	0	tyrosine	59,67	vascular_endothelial_growth_factor_receptor-1	13,58	tyrosine	vascular endothelial growth factor receptor-1	CHEBI:18186	14254(Tax:10090)	Chemical	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Signaling of vascular_endothelial_growth_factor_receptor-1 tyrosine kinase promotes rheumatoid_arthritis through activation of monocytes/macrophages .
15867237	0	tyrosine	125,133	vascular_endothelial_growth_factor_receptor-2	42,87	tyrosine	vascular endothelial growth factor receptor-2	CHEBI:18186	3791	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|amod|END_ENTITY	A multicenter phase II trial of ZD6474 , a vascular_endothelial_growth_factor_receptor-2 and epidermal_growth_factor_receptor tyrosine kinase inhibitor , in patients with previously treated metastatic breast_cancer .
16000000	0	tyrosine	252,260	vascular_endothelial_growth_factor_receptor-2	206,251	tyrosine	vascular endothelial growth factor receptor-2	CHEBI:18186	3791	Chemical	Gene	kinases|compound|START_ENTITY kinases|amod|END_ENTITY	Synthesis and structure-activity relationships of soluble 7-substituted_3 - -LRB- 3,5-dimethoxyphenyl -RRB- -1,6 - naphthyridin-2-amines and related ureas as dual inhibitors of the fibroblast_growth_factor_receptor-1 and vascular_endothelial_growth_factor_receptor-2 tyrosine kinases .
16685739	0	tyrosine	69,77	vascular_endothelial_growth_factor_receptor_3	14,59	tyrosine	vascular endothelial growth factor receptor 3	CHEBI:18186	2324	Chemical	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of vascular_endothelial_growth_factor_receptor_3 and Tie1 tyrosine kinase receptor on acute leukemia cells .
7535775	0	tyrosine	18,26	vav	50,53	tyrosine	vav	CHEBI:18186	7409	Chemical	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Insulin-dependent tyrosine phosphorylation of the vav protooncogene product in cells of hematopoietic origin .
7690544	0	tyrosine	22,30	vav	54,57	tyrosine	vav	CHEBI:18186	7409	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|product product|amod|END_ENTITY	Interleukin-2 induces tyrosine phosphorylation of the vav proto-oncogene product in human T cells : lack of requirement for the tyrosine kinase lck .
10967554	0	tyrosine	98,106	vitamin_D_receptor	130,148	tyrosine	vitamin D receptor	CHEBI:18186	22337(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Activation of Src kinase in skeletal muscle cells by 1 , 1,25 - -LRB- OH -LRB- 2 -RRB- -RRB- - vitamin_D -LRB- 3 -RRB- correlates with tyrosine phosphorylation of the vitamin_D_receptor -LRB- VDR -RRB- and VDR-Src interaction .
10510363	0	tyrosine	67,75	zeta-associated_protein-70	31,57	tyrosine	zeta-associated protein-70	CHEBI:18186	7535	Chemical	Gene	kinase|amod|START_ENTITY kinase|amod|END_ENTITY	LFA-1 to LFA-1 signals involve zeta-associated_protein-70 -LRB- ZAP-70 -RRB- tyrosine kinase : relevance for invasion and migration of a T cell hybridoma .
17766589	0	tyrosine198	67,78	beta-actin	98,108	tyrosine198	beta-actin	null	728378	Chemical	Gene	mediated|nmod|START_ENTITY mediated|nmod|END_ENTITY	Tumor_necrosis_factor-alpha causes barrier dysfunction mediated by tyrosine198 and tyrosine218 in beta-actin .
10995469	0	tyrosine216	31,42	glycogen_synthase_kinase-3beta	62,92	tyrosine216	glycogen synthase kinase-3beta	null	84027(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY Regulation|nmod|phosphorylation Regulation|nmod|END_ENTITY	Regulation and localization of tyrosine216 phosphorylation of glycogen_synthase_kinase-3beta in cellular and animal models of neuronal_degeneration .
8325502	0	tyrosine89	4,14	FKBP12	32,38	tyrosine89	FKBP12	null	2280	Chemical	Gene	residue|amod|START_ENTITY residue|nmod|END_ENTITY	The tyrosine89 residue of yeast FKBP12 is required for rapamycin binding .
11237712	0	tyrosine_1062	23,36	BMK1	14,18	tyrosine 1062	BMK1	null	5598	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of BMK1 via tyrosine_1062 in RET by GDNF and MEN2A mutation .
11733580	0	tyrosines	34,43	CC_chemokine_receptor_5	74,97	tyrosines	CC chemokine receptor 5	null	1234	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Sialylated O-glycans and sulfated tyrosines in the NH2-terminal domain of CC_chemokine_receptor_5 contribute to high affinity binding of chemokines .
8503171	0	tyrosines	33,42	NS-1	50,54	tyrosines	NS-1	null	1489590(Tax:10794)	Chemical	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	Mutational analysis of conserved tyrosines in the NS-1 protein of the parvovirus minute_virus_of_mice .
18663126	0	tyrosines	22,31	SLP76	16,21	tyrosines	SLP76	null	16822(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|Requirements Requirements|nmod|END_ENTITY	Requirements of SLP76 tyrosines in ITAM and integrin receptor signaling and in platelet function in vivo .
17197020	0	tyrosines	18,27	TRPV6	80,85	tyrosines	TRPV6	null	55503	Chemical	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of tyrosines in the putative regulatory site of the Ca2 + channel TRPV6 .
22267732	0	tyrosines	21,30	TULA-2	127,133	tyrosines	TULA-2	null	84959	Chemical	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	Once phosphorylated , tyrosines in carboxyl terminus of protein-tyrosine kinase Syk interact with signaling proteins , including TULA-2 , a negative regulator of mast cell degranulation .
23589303	0	tyrosines	24,33	TrkA	49,53	tyrosines	TrkA	null	4914	Chemical	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	Dissecting the roles of tyrosines 490 and 785 of TrkA protein in the induction of downstream protein phosphorylation using chimeric receptors .
7642520	0	tyrosines	48,57	ZAP-70	82,88	tyrosines	ZAP-70	null	7535	Chemical	Gene	mutations|nmod|START_ENTITY mutations|nmod|domain domain|nmod|END_ENTITY	Activating and inhibitory mutations in adjacent tyrosines in the kinase domain of ZAP-70 .
8955094	0	tyrosines	12,21	ZAP-70	54,60	tyrosines	ZAP-70	null	7535	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Mutation of tyrosines 492/493 in the kinase domain of ZAP-70 affects multiple T-cell receptor signaling pathways .
9446647	0	tyrosines	58,67	erythropoietin_receptor	34,57	tyrosines	erythropoietin receptor	null	2057	Chemical	Gene	START_ENTITY|nsubj|roles roles|nmod|END_ENTITY	Redundant and selective roles for erythropoietin_receptor tyrosines in erythropoiesis in vivo .
6636042	0	tyrosines	39,48	fibrinogen	81,91	tyrosines	fibrinogen	null	2244	Chemical	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Comparative study of the iodination of tyrosines in the amino terminal domain of fibrinogen and in N-DSK and fibrin-N-DSK .
16772534	0	tyrosines	113,122	signal_transducer_and_activator_of_transcription_5b	14,65	tyrosines	signal transducer and activator of transcription 5b	null	6777	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|activity activity|amod|END_ENTITY	Modulation of signal_transducer_and_activator_of_transcription_5b activity in breast_cancer cells by mutation of tyrosines within the transactivation domain .
16037381	0	tyrosines	17,26	thyroglobulin	30,43	tyrosines	thyroglobulin	null	7038	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of sulfated tyrosines of thyroglobulin in thyroid hormonosynthesis .
9727040	5	tyrosyl	982,989	CCK	946,949	tyrosyl	p38	CHEBI:37898	81649(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY increased|dobj|phosphorylation increased|nsubj|END_ENTITY	Both CCK and sorbitol also increased the tyrosyl phosphorylation of p38_MAP_kinase .
10976913	0	tyrosyl	88,95	GH_receptor	115,126	tyrosyl	GH receptor	CHEBI:37898	25235(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Mutation of the SHP-2 binding site in growth_hormone _ -LRB- GH -RRB- _ receptor prolongs GH-promoted tyrosyl phosphorylation of GH_receptor , JAK2 , and STAT5B .
7535773	0	tyrosyl	24,31	Grb2	89,93	tyrosyl	Grb2	CHEBI:37898	2885	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Growth_hormone-promoted tyrosyl phosphorylation of SHC proteins and SHC association with Grb2 .
1662205	0	tyrosyl	37,44	Insulin-like_growth_factor-1	0,28	tyrosyl	Insulin-like growth factor-1	CHEBI:37898	3479	Chemical	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Insulin-like_growth_factor-1 induces tyrosyl phosphorylation of nuclear proteins .
8114715	0	tyrosyl	14,21	SH-PTP1	73,80	tyrosyl	SH-PTP1	CHEBI:37898	15170(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Lck-dependent tyrosyl phosphorylation of the phosphotyrosine phosphatase SH-PTP1 in murine T cells .
7535773	0	tyrosyl	24,31	SHC	51,54	tyrosyl	SHC	CHEBI:37898	6464	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|proteins proteins|compound|END_ENTITY	Growth_hormone-promoted tyrosyl phosphorylation of SHC proteins and SHC association with Grb2 .
9507023	0	tyrosyl	44,51	SIRP	29,33	tyrosyl	SIRP	CHEBI:37898	140885	Chemical	Gene	START_ENTITY|nsubj|regulation regulation|nmod|END_ENTITY	Growth_hormone regulation of SIRP and SHP-2 tyrosyl phosphorylation and association .
18378677	0	tyrosyl	74,81	SIRPalpha_and_PZR	56,73	tyrosyl	SIRPalpha and PZR	CHEBI:37898	68481(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|compound|END_ENTITY	Noonan_syndrome-associated SHP-2 / Ptpn11 mutants enhance SIRPalpha_and_PZR tyrosyl phosphorylation and promote adhesion-mediated ERK activation .
7353045	0	tyrosyl	23,30	antithrombin	67,79	tyrosyl	antithrombin	CHEBI:37898	462	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Exposure to solvent of tyrosyl and tryptophanyl residues of bovine antithrombin in the absence and presence of high-affinity and low-affinity heparin .
568547	0	tyrosyl	31,38	carboxypeptidase_B	50,68	tyrosyl	carboxypeptidase B	CHEBI:37898	57094	Chemical	Gene	residue|amod|START_ENTITY residue|nmod|END_ENTITY	The reactivity of a functional tyrosyl residue in carboxypeptidase_B .
10395945	0	tyrosyl	15,22	eps8	65,69	tyrosyl	eps8	CHEBI:37898	13860(Tax:10090)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Enhancement of tyrosyl phosphorylation and protein expression of eps8 by v-Src .
8999900	0	tyrosyl	20,27	insulin_receptor_substrate_1	47,75	tyrosyl	insulin receptor substrate 1	CHEBI:37898	3667	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|kinase kinase|amod|END_ENTITY	Prolactin activates tyrosyl phosphorylation of insulin_receptor_substrate_1 and phosphatidylinositol-3-OH kinase .
7622459	0	tyrosyl	16,23	myeloperoxidase	48,63	tyrosyl	myeloperoxidase	CHEBI:37898	4353	Chemical	Gene	residues|amod|START_ENTITY Chlorination|nmod|residues Chlorination|nmod|peptides peptides|nmod|neutrophils neutrophils|amod|END_ENTITY	Chlorination of tyrosyl residues in peptides by myeloperoxidase and human neutrophils .
9259996	0	tyrosyl	70,77	myeloperoxidase	53,68	tyrosyl	myeloperoxidase	CHEBI:37898	4353	Chemical	Gene	aldehydes|amod|START_ENTITY Pathways|dep|aldehydes Pathways|nmod|oxidation oxidation|nmod|lipoprotein lipoprotein|nmod|END_ENTITY	Pathways for oxidation of low density lipoprotein by myeloperoxidase : tyrosyl radical , reactive aldehydes , hypochlorous_acid and molecular chlorine .
9822676	0	tyrosyl	50,57	myeloperoxidase	79,94	tyrosyl	myeloperoxidase	CHEBI:37898	4353	Chemical	Gene	radical|amod|START_ENTITY detection|nmod|radical generated|nsubj|detection generated|nmod|and_horseradish_peroxidase and_horseradish_peroxidase|amod|END_ENTITY	Electron paramagnetic resonance detection of free tyrosyl radical generated by myeloperoxidase , lactoperoxidase , _ and_horseradish_peroxidase .
15749393	0	tyrosyl	32,39	myoglobin	22,31	tyrosyl	myoglobin	CHEBI:37898	102975021	Chemical	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification of the myoglobin tyrosyl radical by immuno-spin trapping and its dimerization .
14500036	0	tyrosyl	125,132	p47	170,173	tyrosyl	p47	CHEBI:37898	5341	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Effect of three triterpenoid compounds isolated from root bark of Aralia elata on stimulus-induced superoxide generation and tyrosyl phosphorylation and translocation of p47 -LRB- phox -RRB- and p67 -LRB- phox -RRB- to cell membrane in human neutrophil .
8144	0	tyrosyl	77,84	phosphoglycerate_kinase	103,126	tyrosyl	phosphoglycerate kinase	CHEBI:37898	850370(Tax:4932)	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	Spectrophotometric pH titrations and nitration with tetranitromethane of the tyrosyl residues in yeast phosphoglycerate_kinase .
2414774	0	tyrosyl	20,27	pp60c-src	10,19	tyrosyl	pp60c-src	CHEBI:37898	20779(Tax:10090)	Chemical	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Increased pp60c-src tyrosyl kinase activity in human neuroblastomas is associated with amino-terminal tyrosine phosphorylation of the src gene product .
3524569	0	tyrosyl	24,31	tryptophanase	43,56	tyrosyl	tryptophanase	CHEBI:37898	6999	Chemical	Gene	residue|amod|START_ENTITY residue|nmod|END_ENTITY	Catalytic function of a tyrosyl residue in tryptophanase .
2037620	0	tyrphostin	112,122	TGF_alpha	8,17	tyrphostin	TGF alpha	CHEBI:38637	24827(Tax:10116)	Chemical	Gene	studies|nmod|START_ENTITY Role|dep|studies Role|nmod|END_ENTITY	Role of TGF_alpha and its receptor in proliferation of immortalized rat tracheal epithelial cells : studies with tyrphostin and TGF_alpha antisera .
15494464	0	tyrphostin_51	47,60	Epidermal_growth_factor_receptor	0,32	tyrphostin 51	Epidermal growth factor receptor	MESH:C118515	1956	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Epidermal_growth_factor_receptor inhibition by tyrphostin_51 induces apoptosis in luteinized granulosa cells .
10728680	5	tyrphostin_AG490	907,923	Stat3	966,971	tyrphostin AG490	Stat3	MESH:C095512	6774	Chemical	Gene	inhibitor|appos|START_ENTITY inhibited|nsubj|inhibitor inhibited|dobj|activation activation|nmod|END_ENTITY	Furthermore , the Janus kinase inhibitor , tyrphostin_AG490 , inhibited the constitutive activation of Stat3 and suppressed the growth of human prostate_cancer cells .
9192639	0	tyrphostin_AG490	85,101	Stat3	111,116	tyrphostin AG490	Stat3	MESH:C095512	6774	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|amod|END_ENTITY	Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoides : tyrphostin_AG490 inhibits Stat3 activation and growth of mycosis_fungoides_tumor cell lines .
9192639	0	tyrphostin_AG490	85,101	Stat3	57,62	tyrphostin AG490	Stat3	MESH:C095512	6774	Chemical	Gene	inhibits|nsubj|START_ENTITY fungoides|parataxis|inhibits fungoides|nsubj|activation activation|nmod|isoform isoform|nmod|END_ENTITY	Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoides : tyrphostin_AG490 inhibits Stat3 activation and growth of mycosis_fungoides_tumor cell lines .
8640763	0	tyrphostin_AG825	35,51	neu	65,68	tyrphostin AG825	neu	MESH:C098214	2064	Chemical	Gene	Enhancement|nmod|START_ENTITY Enhancement|nmod|END_ENTITY	Enhancement of chemosensitivity by tyrphostin_AG825 in high-p185 -LRB- neu -RRB- expressing non-small_cell_lung_cancer cells .
9637776	0	tyrphostins	42,53	Cdk2	14,18	tyrphostins	Cdk2	MESH:D020032	1017	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Inhibition of Cdk2 activation by selected tyrphostins causes cell cycle arrest at late G1 and S phase .
14561085	0	tyrphostins	87,98	EGFR	102,106	tyrphostins	EGFR	MESH:D020032	1956	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Receptor-guided alignment-based comparative 3D-QSAR studies of benzylidene_malonitrile tyrphostins as EGFR and HER-2 kinase inhibitors .
8183246	0	tyrphostins	26,37	epidermal_growth_factor_receptor	77,109	tyrphostins	epidermal growth factor receptor	MESH:D020032	1956	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	Kinetics of inhibition by tyrphostins of the tyrosine kinase activity of the epidermal_growth_factor_receptor and analysis by a new computer program .
2845965	0	ubiquinol	52,61	cytochrome_c	62,74	ubiquinol	cytochrome c	MESH:C003741	104968582	Chemical	Gene	reductase|amod|START_ENTITY reductase|amod|END_ENTITY	Diffusional effects in the steady state kinetics of ubiquinol cytochrome_c reductase in bovine heart submitochondrial particles .
9048877	0	ubiquinone	45,55	B13	79,82	ubiquinone	B13	MESH:D014451	4698	Chemical	Gene	subunit|amod|START_ENTITY subunit|appos|END_ENTITY	A human cDNA encoding the homologue of NADH : ubiquinone oxidoreductase subunit B13 .
26063804	0	ubiquinone	89,99	NDH-2	117,122	ubiquinone	NDH-2	MESH:D014451	1660	Chemical	Gene	Oxidoreductases|amod|START_ENTITY Oxidoreductases|appos|END_ENTITY	Apoptosis Inducing Factor -LRB- AIF -RRB- and its Family Member , AMID , are Rotenone-Sensitive NADH : ubiquinone Oxidoreductases -LRB- NDH-2 -RRB- .
9860297	0	ubiquinone	31,41	NDUFA8	57,63	ubiquinone	NDUFA8	MESH:D014451	4702	Chemical	Gene	subunit|amod|START_ENTITY subunit|compound|END_ENTITY	The nuclear-encoded human NADH : ubiquinone oxidoreductase NDUFA8 subunit : cDNA cloning , chromosomal localization , tissue distribution , and mutation detection in complex-I-deficient patients .
7607668	0	ubiquinone	78,88	NDUFV2	117,123	ubiquinone	NDUFV2	MESH:D014451	4729	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular cloning and characterization of the active human mitochondrial NADH : ubiquinone oxidoreductase 24-kDa gene -LRB- NDUFV2 -RRB- and its pseudogene .
16597436	0	ubiquinone	67,77	Qcr8p	95,100	ubiquinone	Qcr8p	MESH:D014451	853273(Tax:4932)	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Ubiquinone accumulates in the mitochondria of yeast mutated in the ubiquinone binding protein , Qcr8p .
11231302	0	ubiquinone	13,23	lipoamide_dehydrogenase	27,50	ubiquinone	lipoamide dehydrogenase	MESH:D014451	1738	Chemical	Gene	Reduction|nmod|START_ENTITY Reduction|nmod|END_ENTITY	Reduction of ubiquinone by lipoamide_dehydrogenase .
17428841	0	ubiquinone	11,21	oxidoreductase	22,36	ubiquinone	oxidoreductase	MESH:D014451	7296	Chemical	Gene	deficiency|amod|START_ENTITY deficiency|compound|END_ENTITY	Human NADH : ubiquinone oxidoreductase deficiency : radical changes in mitochondrial morphology ?
19073440	0	ubiquinone	61,71	oxidoreductase	72,86	ubiquinone	oxidoreductase	MESH:D014451	8630	Chemical	Gene	deficiency|amod|START_ENTITY deficiency|compound|END_ENTITY	Unregulated mitochondrial GSK3beta activity results in NADH : ubiquinone oxidoreductase deficiency .
26027619	0	udenafil	22,30	PDE_5	0,5	udenafil	PDE 5	MESH:C419664	8654	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nummod|END_ENTITY	PDE_5 inhibition with udenafil improves left ventricular systolic/diastolic functions and exercise capacity in patients with chronic heart_failure with reduced ejection fraction ; A 12-week , randomized , double-blind , placebo-controlled trial .
18221288	0	udenafil	27,35	phosphodiesterase_type_5	53,77	udenafil	phosphodiesterase type 5	MESH:C419664	8654	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	The efficacy and safety of udenafil , a new selective phosphodiesterase_type_5 inhibitor , in patients with erectile_dysfunction .
21345194	0	ulinastatin	11,22	IL-6	78,82	ulinastatin	IL-6	null	3569	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of ulinastatin and docataxel on breast_tumor growth and expression of IL-6 , IL-8 , and TNF-a .
26668591	0	ulinastatin	33,44	NF-kB	66,71	ulinastatin	NF-kB	null	81736(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of peritoneal lavage with ulinastatin on the expression of NF-kB and TNF-a in multiple organs of rats with severe_acute_pancreatitis .
26617791	0	ulinastatin	25,36	SSAT2	58,63	ulinastatin	SSAT2	null	360547(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|nmod|END_ENTITY	The regulation effect of ulinastatin on the expression of SSAT2 and AQP4 in myocardial tissue of rats after cardiopulmonary resuscitation .
21941782	0	ulinastatin	11,22	heat_shock_protein_70	44,65	ulinastatin	heat shock protein 70	null	266759(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of ulinastatin on the expression of heat_shock_protein_70 and NF-kappaB in lung tissue in rats with paraquat poisoned -RSB- .
25385285	0	ulinastatin	10,21	high_mobility_group_box_1	60,85	ulinastatin	high mobility group box 1	null	3146	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	Effect of ulinastatin on the expression and distribution of high_mobility_group_box_1 in human colon_carcinoma cells in vitro .
22853554	0	ulinastatin	10,21	iNOS	43,47	ulinastatin	iNOS	null	100008833(Tax:9986)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effect of ulinastatin on the expression of iNOS , MMP-2 , and MMP-3 in degenerated nucleus pulposus cells of rabbits .
14558954	0	ulinastatin	12,23	interleukin-8	27,40	ulinastatin	interleukin-8	null	3576	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Effects of ulinastatin on interleukin-8 during one-lung ventilation in surgery -RSB- .
2373894	0	ulinastatin	12,23	leukocyte_elastase	52,70	ulinastatin	leukocyte elastase	null	1991	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	-LSB- Effects of ulinastatin on plasma polymorphonuclear leukocyte_elastase activity and respiratory function in patients undergoing cardiopulmonary bypass -RSB- .
7982256	0	ulinastatin	11,22	leukocyte_elastase	44,62	ulinastatin	leukocyte elastase	null	1991	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of ulinastatin on polymorphonuclear leukocyte_elastase and interleukin_6 levels after hepatectomy .
8712383	0	ulinastatin	14,25	polymorphonuclear_granulocyte_elastase	101,139	ulinastatin	polymorphonuclear granulocyte elastase	null	1991	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|increase increase|nmod|END_ENTITY	The effect of ulinastatin , a human protease inhibitor , on the transfusion-induced increase of plasma polymorphonuclear_granulocyte_elastase .
18442442	0	unoprostone	11,22	extracellular_signal-regulated_kinase	41,78	unoprostone	extracellular signal-regulated kinase	CHEBI:39455	5594	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|amod|END_ENTITY	Effects of unoprostone on phosphorylated extracellular_signal-regulated_kinase expression in endothelin-1-induced retinal and optic_nerve_damage .
7945381	0	unsaturated_fatty_acids	89,112	PKN	14,17	unsaturated fatty acids	PKN	MESH:D005231	5585	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of PKN , a novel 120-kDa protein kinase with leucine zipper-like sequences , by unsaturated_fatty_acids and by limited proteolysis .
16478242	0	unsaturated_fatty_acids	44,67	Prolyl_endopeptidase	0,20	unsaturated fatty acids	Prolyl endopeptidase	MESH:D005231	5550	Chemical	Gene	activity|nmod|START_ENTITY END_ENTITY|dobj|activity	Prolyl_endopeptidase inhibitory activity of unsaturated_fatty_acids .
9417812	0	unsaturated_fatty_acids	11,34	interleukin-1beta	38,55	unsaturated fatty acids	interleukin-1beta	MESH:D005231	3553	Chemical	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Effects of unsaturated_fatty_acids on interleukin-1beta production by human monocytes .
3855556	0	unsaturated_fatty_acids	58,81	phospholipase_A2	29,45	unsaturated fatty acids	phospholipase A2	MESH:D005231	151056	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activity activity|amod|END_ENTITY	Inhibition of human platelet phospholipase_A2 activity by unsaturated_fatty_acids .
17952005	0	uracil	87,93	Dihydropyrimidine_dehydrogenase	0,31	uracil	Dihydropyrimidine dehydrogenase	MESH:D014498	1806	Chemical	Gene	treatment|nmod|START_ENTITY END_ENTITY|nmod|treatment	Dihydropyrimidine_dehydrogenase activity during long-term adjuvant treatment with oral uracil and tegafur for colorectal_cancer .
9829833	0	uracil	111,117	Fur4p	129,134	uracil	Fur4p	MESH:D014498	852309(Tax:4932)	Chemical	Gene	uptake|amod|START_ENTITY uptake|nmod|END_ENTITY	Growth inhibition of Saccharomyces_cerevisiae by the immunosuppressant leflunomide is due to the inhibition of uracil uptake via Fur4p .
12353234	0	uracil	87,93	UPRT	121,125	uracil	UPRT	MESH:D014498	139596	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Gene therapy for intraperitoneally disseminated pancreatic_cancers by Escherichia_coli uracil phosphoribosiltransferase -LRB- UPRT -RRB- gene mediated by restricted replication-competent adenoviral vectors .
22404301	0	uracil	86,92	deoxyuridine_triphosphatase	121,148	uracil	deoxyuridine triphosphatase	MESH:D014498	1854	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Synthesis and discovery of N-carbonylpyrrolidine - or N-sulfonylpyrrolidine-containing uracil derivatives as potent human deoxyuridine_triphosphatase inhibitors .
16428499	0	uracil	4,10	dihydropyrimidine_dehydrogenase	44,75	uracil	dihydropyrimidine dehydrogenase	MESH:D014498	1806	Chemical	Gene	test|amod|START_ENTITY test|nmod|assessment assessment|nmod|activity activity|amod|END_ENTITY	The uracil breath test in the assessment of dihydropyrimidine_dehydrogenase activity : pharmacokinetic relationship between expired 13CO2 and plasma -LSB- 2-13C -RSB- dihydrouracil .
17143493	0	uracil	53,59	dihydropyrimidine_dehydrogenase	86,117	uracil	dihydropyrimidine dehydrogenase	MESH:D014498	1806	Chemical	Gene	efficacy|nmod|START_ENTITY augments|dobj|efficacy augments|advcl|inhibiting inhibiting|dobj|END_ENTITY	Cyclophosphamide augments the anti-tumor efficacy of uracil and tegafur by inhibiting dihydropyrimidine_dehydrogenase .
9617342	0	uracil	95,101	ornithine_decarboxylase	31,54	uracil	ornithine decarboxylase	MESH:D014498	24609(Tax:10116)	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubj|Expression Expression|nmod|END_ENTITY	Expression and localization of ornithine_decarboxylase in reversible papillomatosis induced by uracil in rat bladder .
10725666	0	uracil	75,81	thymidylate_synthase	96,116	uracil	thymidylate synthase	MESH:D014498	100754276	Chemical	Gene	inhibition|amod|START_ENTITY inhibition|amod|END_ENTITY	5-chloro-2 ' - deoxyuridine cytotoxicity results from base excision repair of uracil subsequent to thymidylate_synthase inhibition .
8052259	0	uracil	16,22	uracil-DNA-glycosylase	33,55	uracil	uracil-DNA-glycosylase	MESH:D014498	7374	Chemical	Gene	Recognition|nmod|START_ENTITY Recognition|nmod|END_ENTITY	-LSB- Recognition of uracil in DNA by uracil-DNA-glycosylase from human placenta -RSB- .
17553452	0	uracil	24,30	uracil-DNA_glycosylase	42,64	uracil	uracil-DNA glycosylase	MESH:D014498	7374	Chemical	Gene	removal|amod|START_ENTITY removal|nmod|END_ENTITY	Real-time monitoring of uracil removal by uracil-DNA_glycosylase using fluorescent resonance energy transfer probes .
24878718	0	uranium	33,40	Poli	52,56	uranium	Poli	MESH:D014501	11201	Chemical	Gene	regions|compound|START_ENTITY regions|nmod|END_ENTITY	Indoor radon measurements in the uranium regions of Poli and Lolodorf , Cameroon .
16231126	0	uranium	39,46	cytochrome_P450	88,103	uranium	cytochrome P450	MESH:D014501	25251(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|enzymes enzymes|amod|END_ENTITY	Short-term hepatic effects of depleted uranium on xenobiotic and bile_acid metabolizing cytochrome_P450 enzymes in the rat .
23837070	0	urantide	38,46	urotensin_II_receptor	4,25	urantide	urotensin II receptor	MESH:C492079	57305(Tax:10116)	Chemical	Gene	antagonist|appos|START_ENTITY antagonist|compound|END_ENTITY	The urotensin_II_receptor antagonist , urantide , protects against atherosclerosis in rats .
26251846	0	urate	88,93	URAT1	107,112	urate	URAT1	MESH:D014527	20521(Tax:10090)	Chemical	Gene	transporter|amod|START_ENTITY transporter|appos|END_ENTITY	Transcriptome-based reconstructions from the murine knockout suggest involvement of the urate transporter , URAT1 -LRB- slc22a12 -RRB- , in novel metabolic pathways .
26907620	0	urate	90,95	URAT1	51,56	urate	URAT1	MESH:D014527	116085	Chemical	Gene	lowered|dobj|START_ENTITY lowered|nsubj|effects effects|nmod|UR-1102 UR-1102|compound|END_ENTITY	Stronger uricosuric effects of the novel selective URAT1 inhibitor UR-1102 lowered plasma urate in tufted_capuchin monkeys to a greater extent than benzbromarone .
12709047	0	urea	38,42	Argininosuccinate_synthetase	0,28	urea	Argininosuccinate synthetase	MESH:D014508	445	Chemical	Gene	cycle|compound|START_ENTITY END_ENTITY|nmod|cycle	Argininosuccinate_synthetase from the urea cycle to the citrulline-NO cycle .
15262222	0	urea	61,65	Calcineurin_B	0,13	urea	Calcineurin B	MESH:D014508	5534	Chemical	Gene	protects|nmod|START_ENTITY protects|nsubj|END_ENTITY	Calcineurin_B protects calcineurin_A against denaturation by urea .
22010949	0	urea	33,37	DUR3	5,9	urea	DUR3	MESH:D014508	834574(Tax:3702)	Chemical	Gene	transport|compound|START_ENTITY mediates|dobj|transport mediates|nsubj|END_ENTITY	Rice DUR3 mediates high-affinity urea transport and plays an effective role in improvement of urea acquisition and utilization when expressed in Arabidopsis .
7929290	0	urea	13,17	Egr-1	59,64	urea	Egr-1	MESH:D014508	13653(Tax:10090)	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|transcription transcription|nmod|END_ENTITY	Hyperosmotic urea increases transcription and synthesis of Egr-1 in murine inner medullary collecting duct -LRB- mIMCD3 -RRB- cells .
15684682	0	urea	72,76	Insulin	0,7	urea	Insulin	MESH:D014508	3630	Chemical	Gene	synthesis|compound|START_ENTITY regulation|nmod|synthesis mediates|dobj|regulation mediates|nsubj|concentration concentration|compound|END_ENTITY	Insulin concentration during preconditioning mediates the regulation of urea synthesis during exposure to amino_acid-supplemented plasma .
10514515	0	urea	56,60	Kidd_blood_group	39,55	urea	Kidd blood group	MESH:D014508	6563	Chemical	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	At physiological expression levels the Kidd_blood_group / urea transporter protein is not a water channel .
9582331	0	urea	65,69	Kidd_blood_group	48,64	urea	Kidd blood group	MESH:D014508	6563	Chemical	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Characterization of the gene encoding the human Kidd_blood_group / urea transporter protein .
23796783	0	urea	40,44	Rab14	13,18	urea	Rab14	MESH:D014508	494665(Tax:8355)	Chemical	Gene	activity|compound|START_ENTITY END_ENTITY|dobj|activity	Small GTPase Rab14 down-regulates UT-A1 urea transport activity through enhanced clathrin-dependent endocytosis .
21824976	0	urea	106,110	SLC14A1	95,102	urea	SLC14A1	MESH:D014508	6563	Chemical	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	A genome-wide association study of bladder_cancer identifies a new susceptibility locus within SLC14A1 , a urea transporter gene on chromosome 18q12 .3 .
23754249	0	urea	112,116	SLC14A1	135,142	urea	SLC14A1	MESH:D014508	6563	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Differential urinary specific gravity as a molecular phenotype of the bladder_cancer genetic association in the urea transporter gene , SLC14A1 .
16252096	6	urea	1043,1047	TPX	1090,1093	urea	PON	MESH:D014508	5444	Chemical	Gene	had|nsubj|START_ENTITY had|dobj|correlation correlation|nmod|END_ENTITY	Serum urea had significant positive correlation with TPX and OSI -LRB- P < 0.05 -RRB- .
18945830	0	urea	29,33	TonEBP	73,79	urea	TonEBP	MESH:D014508	307820(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|nmod|directions directions|nmod|END_ENTITY	Urea and NaCl regulate UT-A1 urea transporter in opposing directions via TonEBP pathway during osmotic diuresis .
11463720	0	urea	5,9	UT-A	0,4	urea	UT-A	MESH:D014508	8170	Chemical	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	UT-A urea transporter protein in heart : increased abundance during uremia , hypertension , and heart_failure .
15649775	0	urea	14,18	UT-A	32,36	urea	UT-A	MESH:D014508	443267(Tax:9940)	Chemical	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	Expression of urea transporter -LRB- UT-A -RRB- mRNA in papilla and pelvic epithelium of kidney in normal and low protein fed sheep .
10799304	0	urea	80,84	UT-A2	74,79	urea	UT-A2	MESH:D014508	8170	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Hyperosmotic NaCl and urea synergistically regulate the expression of the UT-A2 urea transporter in vitro and in vivo .
11546670	0	urea	20,24	UT-B	37,41	urea	UT-B	MESH:D014508	54301(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY Localization|nmod|transporter END_ENTITY|nsubj|Localization	Localization of the urea transporter UT-B protein in human and rat erythrocytes and tissues .
15100356	0	urea	16,20	UT-B	105,109	urea	UT-B	MESH:D014508	108052(Tax:10090)	Chemical	Gene	Upregulation|nmod|START_ENTITY transporter|nsubj|Upregulation transporter|dobj|AQP2 AQP2|nmod|mice mice|acl|lacking lacking|dobj|END_ENTITY	Upregulation of urea transporter UT-A2 and water channels AQP2 and AQP3 in mice lacking urea transporter UT-B .
15798087	0	urea	50,54	UT-B	45,49	urea	UT-B	MESH:D014508	54301(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Regulated expression of renal and intestinal UT-B urea transporter in response to varying urea load .
15798087	0	urea	90,94	UT-B	45,49	urea	UT-B	MESH:D014508	54301(Tax:10116)	Chemical	Gene	load|compound|START_ENTITY urea|nmod|load urea|nsubj|expression expression|nmod|END_ENTITY	Regulated expression of renal and intestinal UT-B urea transporter in response to varying urea load .
15845882	0	urea	61,65	UT-B	0,4	urea	UT-B	MESH:D014508	493988(Tax:9913)	Chemical	Gene	transport|compound|START_ENTITY role|nmod|transport rumen|dep|role expressed|nmod|rumen expressed|nsubjpass|END_ENTITY	UT-B is expressed in bovine rumen : potential role in ruminal urea transport .
17506977	0	urea	38,42	UT-B	78,82	urea	UT-B	MESH:D014508	108052(Tax:10090)	Chemical	Gene	efficiencies|nmod|START_ENTITY analogues|nsubj|efficiencies analogues|nmod|END_ENTITY	Comparative transport efficiencies of urea analogues through urea transporter UT-B .
19471871	0	urea	63,67	UT-B	80,84	urea	UT-B	MESH:D014508	108052(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY lacking|dobj|transporter mice|acl|lacking electrocardiogram|nmod|mice END_ENTITY|nsubj|electrocardiogram	Surface electrocardiogram and action potential in mice lacking urea transporter UT-B .
22491419	0	urea	39,43	UT-B	56,60	urea	UT-B	MESH:D014508	108052(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY inhibitors|nmod|transporter END_ENTITY|nsubj|inhibitors	Triazolothienopyrimidine inhibitors of urea transporter UT-B reduce urine concentration .
15563580	0	urea	6,10	UT-B1	0,5	urea	UT-B1	MESH:D014508	108052(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	UT-B1 urea transporter is expressed along the urinary and gastrointestinal tracts of the mouse .
17081500	0	urea	6,10	UT-B1	0,5	urea	UT-B1	MESH:D014508	6563	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	UT-B1 urea transporter plays a noble role as active water transporter in C6 glial cells .
21127847	0	urea	31,35	UT-B1	0,5	urea	UT-B1	MESH:D014508	54301(Tax:10116)	Chemical	Gene	flux|compound|START_ENTITY mediates|dobj|flux mediates|nsubj|END_ENTITY	UT-B1 mediates transepithelial urea flux in the rat gastrointestinal tract .
1688084	0	urea	42,46	arylsulfatase-A	108,123	urea	arylsulfatase-A	MESH:D014508	315222(Tax:10116)	Chemical	Gene	generation|nmod|START_ENTITY generation|nmod|END_ENTITY	Intralysosomal generation of ammonia from urea by endocytosed urease results in secretion of free lysosomal arylsulfatase-A and increased activity of membrane-bound beta-glucosidase in cultured brain cells .
3223934	0	urea	40,44	cathepsin_B	60,71	urea	cathepsin B	MESH:D014508	102173295	Chemical	Gene	mechanism|nmod|START_ENTITY mechanism|nmod|END_ENTITY	A probable mechanism of inactivation by urea of goat spleen cathepsin_B .
12019204	0	urea	136,140	cytochrome_P450_2E1	94,113	urea	cytochrome P450 2E1	MESH:D014508	25086(Tax:10116)	Chemical	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Increase in urea in conjunction with L-arginine metabolism in the liver leads to induction of cytochrome_P450_2E1 -LRB- CYP2E1 -RRB- : the role of urea in CYP2E1 induction by acute_renal_failure .
7548158	0	urea	68,72	dihydrofolate_reductase	28,51	urea	dihydrofolate reductase	MESH:D014508	427317(Tax:9031)	Chemical	Gene	solutions|compound|START_ENTITY END_ENTITY|nmod|solutions	Activation of chicken liver dihydrofolate_reductase in concentrated urea solutions .
23643539	0	urea	43,47	fumarate_hydratase	21,39	urea	fumarate hydratase	MESH:D014508	2271	Chemical	Gene	metabolism|compound|START_ENTITY role|nmod|metabolism role|nmod|END_ENTITY	A role for cytosolic fumarate_hydratase in urea cycle metabolism and renal_neoplasia .
11443176	0	urea	99,103	growth_hormone	16,30	urea	growth hormone	MESH:D014508	2688	Chemical	Gene	excretion|compound|START_ENTITY decreases|dobj|excretion decreases|nsubj|Continuation Continuation|nmod|substitution substitution|amod|END_ENTITY	Continuation of growth_hormone -LRB- GH -RRB- substitution during fasting in GH-deficient patients decreases urea excretion and conserves protein synthesis .
12474568	0	urea	51,55	growth_hormone	33,47	urea	growth hormone	MESH:D014508	2688	Chemical	Gene	kinetics|compound|START_ENTITY END_ENTITY|nmod|kinetics	-LSB- The effect of recombinant human growth_hormone on urea and creatinine kinetics and selected dialysis adequacy parameters in children with end-stage_renal_failure treated with peritoneal dialysis -RSB- .
1806470	0	urea	36,40	growth_hormone	60,74	urea	growth hormone	MESH:D014508	2688	Chemical	Gene	treatment|compound|START_ENTITY treatment|nmod|END_ENTITY	Combination ultrafiltration and 6 M urea treatment of human growth_hormone effectively minimizes risk from potential Creutzfeldt-Jakob_disease_virus contamination .
8074908	0	urea	49,53	growth_hormone	14,28	urea	growth hormone	MESH:D014508	2688	Chemical	Gene	levels|compound|START_ENTITY effect|nmod|levels effect|nmod|END_ENTITY	The effect of growth_hormone on growth and blood urea levels in children with chronic_renal_failure .
8400793	0	urea	74,78	growth_hormone	56,70	urea	growth hormone	MESH:D014508	2688	Chemical	Gene	rate|compound|START_ENTITY END_ENTITY|nmod|rate	-LSB- Effects of short-term application of recombinant human growth_hormone on urea production rate in patients in the early postoperative phase -RSB- .
9688877	0	urea	68,72	growth_hormone	11,25	urea	growth hormone	MESH:D014508	81668(Tax:10116)	Chemical	Gene	synthesis|compound|START_ENTITY ability|nmod|synthesis increase|nmod|ability END_ENTITY|nmod|increase	Effects of growth_hormone on steroid-induced increase in ability of urea synthesis and urea enzyme mRNA levels .
15189812	0	urea	71,75	hUT-A6	89,95	urea	hUT-A6	MESH:D014508	8170	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	Characterization of a human colonic cDNA encoding a structurally novel urea transporter , hUT-A6 .
2538143	0	urea	30,34	insulin	36,43	urea	insulin	MESH:D014508	397415(Tax:9823)	Chemical	Gene	gum|nmod|START_ENTITY Effects|nmod|gum Effects|appos|END_ENTITY	Effects of guar gum on plasma urea , insulin and glucose in the growing pig .
7836708	0	urea	34,38	insulin	11,18	urea	insulin	MESH:D014508	3630	Chemical	Gene	synthesis|compound|START_ENTITY Effects|nmod|synthesis Effects|nmod|END_ENTITY	Effects of insulin and glucose on urea synthesis in normal man , independent of pancreatic hormone secretion .
947936	0	urea	34,38	insulin	15,22	urea	insulin	MESH:D014508	3630	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of insulin on urinary urea and ammonia production .
14499909	0	urea	29,33	lysozyme	39,47	urea	lysozyme	MESH:D014508	4069	Chemical	Gene	interactions|nmod|START_ENTITY interactions|nmod|END_ENTITY	Preferential interactions of urea with lysozyme and their linkage to protein denaturation .
17148784	0	urea	27,31	mUT-A3	20,26	urea	mUT-A3	MESH:D014508	27411(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	Acute regulation of mUT-A3 urea transporter expressed in a MDCK cell line .
8261908	0	urea	57,61	milk	85,89	urea	milk	MESH:D014508	100532204	Chemical	Gene	content|compound|START_ENTITY content|nmod|END_ENTITY	-LSB- Analysis of environmental and genetic influences on the urea and acetone content in milk from the breeds German spotted cattle and German brown cattle -RSB- .
12464281	0	urea	25,29	myosin	92,98	urea	myosin	MESH:D014508	79784	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Counteracting effects of urea and methylamines in function and structure of skeletal muscle myosin .
21324985	0	urea	11,15	myosin	110,116	urea	myosin	MESH:D014508	79784	Chemical	Gene	Effects|nmod|START_ENTITY hydrolysis|nsubj|Effects hydrolysis|nmod|molecules molecules|compound|END_ENTITY	Effects of urea and guanidine_hydrochloride on the sliding movement of actin filaments with ATP hydrolysis by myosin molecules .
2163337	0	urea	22,26	prolactin	38,47	urea	prolactin	MESH:D014508	24683(Tax:10116)	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|compound|END_ENTITY	The permeant molecule urea stimulates prolactin secretion in GH4C1 cells by inducing Ca2 + influx through dihydropyridine-sensitive Ca2 + channels .
7657826	0	urea	55,59	rUT2	73,77	urea	rUT2	MESH:D014508	29277(Tax:10116)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Cloning and regulation of expression of the rat kidney urea transporter -LRB- rUT2 -RRB- .
21849488	0	urea	53,57	urea	29,33	urea	UT-B	MESH:D014508	108052(Tax:10090)	Chemical	Gene	handling|compound|START_ENTITY END_ENTITY|nmod|handling	Role of thin descending limb urea transport in renal urea handling and the urine concentrating mechanism .
21686211	0	urea	20,24	vasopressin	38,49	urea	vasopressin	MESH:D014508	551	Chemical	Gene	Regulation|nmod|START_ENTITY transport|nsubj|Regulation transport|nmod|END_ENTITY	Regulation of renal urea transport by vasopressin .
22866010	0	urea_nitrogen	6,19	albumin	29,36	urea nitrogen	albumin	null	213	Chemical	Gene	START_ENTITY|nmod|ratio ratio|compound|END_ENTITY	Blood urea_nitrogen to serum albumin ratio independently predicts mortality and severity of community-acquired_pneumonia .
23123726	0	ureas	65,70	PAR1	135,139	ureas	PAR1	CHEBI:47857	2149	Chemical	Gene	evaluation|nmod|START_ENTITY evaluation|nmod|END_ENTITY	Design , synthesis and biological evaluation of new peptide-based ureas and thioureas as potential antagonists of the thrombin receptor PAR1 .
16000000	0	ureas	134,139	fibroblast_growth_factor_receptor-1	166,201	ureas	fibroblast growth factor receptor-1	CHEBI:47857	2260	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Synthesis and structure-activity relationships of soluble 7-substituted_3 - -LRB- 3,5-dimethoxyphenyl -RRB- -1,6 - naphthyridin-2-amines and related ureas as dual inhibitors of the fibroblast_growth_factor_receptor-1 and vascular_endothelial_growth_factor_receptor-2 tyrosine kinases .
7976356	0	urethane	78,86	CA1	64,67	urethane	CA1	MESH:D014520	310218(Tax:10116)	Chemical	Gene	region|nmod|START_ENTITY region|compound|END_ENTITY	-LSB- Effect of xylazine on acetylcholine content of the hippocampal CA1 region in urethane anesthetized rats -RSB- .
22797328	0	urethane	94,102	STAT3	15,20	urethane	STAT3	MESH:D014520	20848(Tax:10090)	Chemical	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of STAT3 , NF-kB and associated downstream molecules before and after the onset of urethane induced lung_tumors in mouse .
23998049	0	uric_Acid	47,56	insulin	25,32	uric Acid	insulin	MESH:D014527	3630	Chemical	Gene	START_ENTITY|nsubj|Correlation Correlation|nmod|END_ENTITY	Correlation of the serum insulin and the serum uric_Acid levels with the glycated haemoglobin levels in the patients of type_2_diabetes_mellitus .
11328912	0	uric_acid	84,93	ACE	14,17	uric acid	ACE	MESH:D014527	1636	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|inhibitor inhibitor|compound|END_ENTITY	The effect of ACE inhibitor and angiotensin II receptor antagonist therapy on serum uric_acid levels and potassium homeostasis in hypertensive_renal_transplant_recipients treated with CsA .
2862346	0	uric_acid	6,15	ACE	17,20	uric acid	ACE	MESH:D014527	1636	Chemical	Gene	inhibitors|advcl|START_ENTITY inhibitors|nsubj|END_ENTITY	Serum uric_acid , ACE inhibitors , and natriuresis .
21821372	0	uric_acid	45,54	C-reactive_protein	25,43	uric acid	C-reactive protein	MESH:D014527	1401	Chemical	Gene	START_ENTITY|nsubj|association association|nmod|END_ENTITY	The association of serum C-reactive_protein , uric_acid and magnesium with insulin resistance in Chinese postmenopausal women with prediabetes or early untreated diabetes .
25229885	0	uric_acid	27,36	C5a	11,14	uric acid	C5a	MESH:D014527	728	Chemical	Gene	START_ENTITY|nsubj|potentiates potentiates|amod|END_ENTITY	Complement C5a potentiates uric_acid crystal-induced IL-1b production .
24325097	0	uric_acid	24,33	CRP	42,45	uric acid	CRP	MESH:D014527	1401	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	-LSB- Oxidative mechanism of uric_acid induced CRP expression in human umbilical vein endothelial cells -RSB- .
25229885	0	uric_acid	27,36	IL-1b	53,58	uric acid	IL-1b	MESH:D014527	3553	Chemical	Gene	START_ENTITY|dobj|production production|compound|END_ENTITY	Complement C5a potentiates uric_acid crystal-induced IL-1b production .
16140208	0	uric_acid	85,94	Insulin	0,7	uric acid	Insulin	MESH:D014527	3630	Chemical	Gene	defenses|amod|START_ENTITY involvement|nmod|defenses neuroprotection|dep|involvement neuroprotection|compound|END_ENTITY	Insulin neuroprotection against oxidative stress in cortical neurons -- involvement of uric_acid and glutathione antioxidant defenses .
16407889	0	uric_acid	16,25	NALP3	48,53	uric acid	NALP3	MESH:D014527	216799(Tax:10090)	Chemical	Gene	crystals|amod|START_ENTITY activate|nsubj|crystals activate|dobj|inflammasome inflammasome|compound|END_ENTITY	Gout-associated uric_acid crystals activate the NALP3 inflammasome .
19783673	0	uric_acid	90,99	NALP3	56,61	uric acid	NALP3	MESH:D014527	216799(Tax:10090)	Chemical	Gene	release|nmod|START_ENTITY inflammasome|nmod|release inflammasome|compound|END_ENTITY	Pure Hemozoin is inflammatory in vivo and activates the NALP3 inflammasome via release of uric_acid .
25813103	0	uric_acid	8,17	NALP3	28,33	uric acid	NALP3	MESH:D014527	114548	Chemical	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	Soluble uric_acid increases NALP3 inflammasome and interleukin-1b expression in human primary renal proximal tubule epithelial cells through the Toll-like receptor 4-mediated pathway .
21366895	0	uric_acid	6,15	SLC22A12	42,50	uric acid	SLC22A12	MESH:D014527	116085	Chemical	Gene	START_ENTITY|nmod|genotype genotype|compound|END_ENTITY	Serum uric_acid distribution according to SLC22A12 W258X genotype in a cross-sectional study of a general Japanese population .
18327256	0	uric_acid	18,27	SLC2A9	0,6	uric acid	SLC2A9	MESH:D014527	56606	Chemical	Gene	concentrations|amod|START_ENTITY influences|dobj|concentrations influences|nsubj|END_ENTITY	SLC2A9 influences uric_acid concentrations with pronounced sex-specific effects .
18487473	0	uric_acid	83,92	SLC2A9	62,68	uric acid	SLC2A9	MESH:D014527	56606	Chemical	Gene	levels|amod|START_ENTITY variants|nmod|levels variants|compound|END_ENTITY	Sex-specific association of the putative fructose transporter SLC2A9 variants with uric_acid levels is modified by BMI .
20162744	0	uric_acid	105,114	SLC2A9	69,75	uric acid	SLC2A9	MESH:D014527	56606	Chemical	Gene	START_ENTITY|nsubj|Interactions Interactions|nmod|variants variants|nmod|glucose_transporter_type_9 glucose_transporter_type_9|appos|END_ENTITY	Interactions between genetic variants in glucose_transporter_type_9 -LRB- SLC2A9 -RRB- and dietary habits in serum uric_acid regulation .
20197412	0	uric_acid	17,26	SLC2A9	45,51	uric acid	SLC2A9	MESH:D014527	56606	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Variation in the uric_acid transporter gene -LRB- SLC2A9 -RRB- and memory performance .
20972595	0	uric_acid	57,66	SLC2A9	34,40	uric acid	SLC2A9	MESH:D014527	56606	Chemical	Gene	START_ENTITY|nsubj|Association Association|nmod|SNP SNP|nmod|gene gene|nummod|END_ENTITY	Association of an intronic SNP of SLC2A9 gene with serum uric_acid levels in the Chinese male Han population by high-resolution melting method .
22212408	0	uric_acid	30,39	SLC2A9	11,17	uric acid	SLC2A9	MESH:D014527	56606	Chemical	Gene	levels|amod|START_ENTITY variants|nmod|levels variants|nsubj|Effects Effects|nmod|END_ENTITY	Effects of SLC2A9 variants on uric_acid levels in a Korean population .
23272134	0	uric_acid	11,20	SLC2A9	80,86	uric acid	SLC2A9	MESH:D014527	56606	Chemical	Gene	levels|amod|START_ENTITY Changes|nmod|levels associated|nsubjpass|Changes associated|nmod|variants variants|nummod|END_ENTITY	Changes in uric_acid levels following bariatric surgery are not associated with SLC2A9 variants in the Swedish Obese Subjects Study .
24301058	0	uric_acid	63,72	SLC2A9	29,35	uric acid	SLC2A9	MESH:D014527	56606	Chemical	Gene	START_ENTITY|nsubj|Replication Replication|nmod|effect effect|nmod|variation variation|nummod|END_ENTITY	Replication of the effect of SLC2A9 genetic variation on serum uric_acid levels in American Indians .
24379826	0	uric_acid	91,100	SLC2A9	73,79	uric acid	SLC2A9	MESH:D014527	56606	Chemical	Gene	levels|amod|START_ENTITY extends|nmod|levels extends|dobj|association association|nmod|END_ENTITY	Genome-wide association analysis confirms and extends the association of SLC2A9 with serum uric_acid levels to Mexican Americans .
25007794	0	uric_acid	64,73	SLC2A9	31,37	uric acid	SLC2A9	MESH:D014527	56606	Chemical	Gene	concentrations|amod|START_ENTITY associated|nmod|concentrations associated|nsubjpass|polymorphisms polymorphisms|nmod|END_ENTITY	Copy number polymorphisms near SLC2A9 are associated with serum uric_acid concentrations .
25283508	0	uric_acid	6,15	SLC2A9	64,70	uric acid	SLC2A9	MESH:D014527	56606	Chemical	Gene	levels|amod|START_ENTITY associated|nsubjpass|levels associated|nmod|polymorphisms polymorphisms|nmod|SF1 SF1|nummod|END_ENTITY	Serum uric_acid levels are associated with polymorphisms in the SLC2A9 , SF1 , and GCKR genes in a Chinese population .
25634581	0	uric_acid	20,29	SLC2A9	58,64	uric acid	SLC2A9	MESH:D014527	56606	Chemical	Gene	Associations|nmod|START_ENTITY related|nsubj|Associations related|nmod|loci loci|compound|END_ENTITY	Associations of the uric_acid related genetic variants in SLC2A9 and ABCG2 loci with coronary_heart_disease risk .
25634581	0	uric_acid	20,29	SLC2A9	58,64	uric acid	SLC2A9	MESH:D014527	56606	Chemical	Gene	Associations|nmod|START_ENTITY related|nsubj|Associations related|nmod|loci loci|compound|END_ENTITY	Associations of the uric_acid related genetic variants in SLC2A9 and ABCG2 loci with coronary_heart_disease risk .
24934285	0	uric_acid	15,24	angiotensinogen	44,59	uric acid	angiotensinogen	MESH:D014527	183	Chemical	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	Elevated serum uric_acid is associated with angiotensinogen in obese patients with untreated hypertension .
15921030	0	uric_acid	49,58	apolipoprotein_E	10,26	uric acid	apolipoprotein E	MESH:D014527	348	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|polymorphism polymorphism|amod|END_ENTITY	Effect of apolipoprotein_E polymorphism on serum uric_acid levels in healthy subjects .
26328161	0	uric_acid	38,47	erythropoietin	14,28	uric acid	erythropoietin	MESH:D014527	24335(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|END_ENTITY	The effect of erythropoietin on serum uric_acid levels during renal_ischemia reperfusion injury in rats .
22132992	0	uric_acid	6,15	hURAT1	31,37	uric acid	hURAT1	MESH:D014527	116085	Chemical	Gene	START_ENTITY|dobj|1 1|appos|END_ENTITY	Human uric_acid transporter 1 -LRB- hURAT1 -RRB- : an inhibitor structure-activity relationship -LRB- SAR -RRB- study .
11296961	0	uric_acid	49,58	insulin	78,85	uric acid	insulin	MESH:D014527	3630	Chemical	Gene	START_ENTITY|advcl|fasting fasting|dobj|END_ENTITY	Gender differences in the relationships of serum uric_acid with fasting serum insulin and plasma glucose in patients without diabetes .
12160192	0	uric_acid	19,28	insulin	48,55	uric acid	insulin	MESH:D014527	3630	Chemical	Gene	START_ENTITY|nmod|amelioration amelioration|nmod|resistance resistance|compound|END_ENTITY	Decreases in serum uric_acid by amelioration of insulin resistance in overweight hypertensive patients : effect of a low-energy diet and an insulin-sensitizing agent .
15838747	0	uric_acid	15,24	insulin	80,87	uric acid	insulin	MESH:D014527	3630	Chemical	Gene	levels|amod|START_ENTITY correlated|nsubjpass|levels correlated|nmod|resistance resistance|compound|END_ENTITY	Elevated serum uric_acid levels in gestational hypertension are correlated with insulin resistance .
21933003	0	uric_acid	8,17	insulin	40,47	uric acid	insulin	MESH:D014527	3630	Chemical	Gene	START_ENTITY|advcl|identify identify|dobj|resistance resistance|compound|END_ENTITY	Optimal uric_acid threshold to identify insulin resistance in healthy women .
22036135	10	uric_acid	1423,1432	insulin	1484,1491	uric acid	insulin	MESH:D014527	3630	Chemical	Gene	>|amod|START_ENTITY mg/dL|nsubj|> Using|ccomp|mg/dL diagnose|advcl|Using diagnose|dobj|resistance resistance|compound|END_ENTITY	Using uric_acid > = 5.0 mg/dL as a cutoff point , we could diagnose insulin resistance with 75.4 % sensitivity and 73.1 % specificity .
25374817	0	uric_acid	30,39	insulin	8,15	uric acid	insulin	MESH:D014527	3630	Chemical	Gene	nephrolithiasis|amod|START_ENTITY Role|nmod|nephrolithiasis Role|nmod|resistance resistance|compound|END_ENTITY	Role of insulin resistance in uric_acid nephrolithiasis .
6130890	0	uric_acid	15,24	insulin	100,107	uric acid	insulin	MESH:D014527	396145(Tax:9031)	Chemical	Gene	production|amod|START_ENTITY Stimulation|nmod|production Stimulation|nmod|END_ENTITY	Stimulation of uric_acid production and depression of increase in plasma glutamine concentration by insulin in chickens infused with ammonia .
8923162	0	uric_acid	6,15	insulin	17,24	uric acid	insulin	MESH:D014527	3630	Chemical	Gene	START_ENTITY|dobj|secretion secretion|compound|END_ENTITY	Serum uric_acid , insulin secretion and resistance in nonhyperuricemic and hyperuricemic_obese female subjects .
8959528	0	uric_acid	52,61	insulin	25,32	uric acid	insulin	MESH:D014527	3630	Chemical	Gene	START_ENTITY|nsubj|relationship relationship|nmod|END_ENTITY	The relationship between insulin , glucose and serum uric_acid and their contribution to the progression of renal_damage in patients with primary glomerulonephritis .
19821833	0	uric_acid	10,19	matrix_metalloproteinases_2_and_9	75,108	uric acid	matrix metalloproteinases 2 and 9	MESH:D014527	81686(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|role role|nmod|END_ENTITY	Effect of uric_acid on gentamicin-induced nephrotoxicity in rats - role of matrix_metalloproteinases_2_and_9 .
24340056	0	uric_acid	6,15	parathyroid_hormone	85,104	uric acid	parathyroid hormone	MESH:D014527	5741	Chemical	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	Serum uric_acid is associated with left_ventricular_hypertrophy independent of serum parathyroid_hormone in male cardiac patients .
3895007	0	uric_acid	29,38	renin	7,12	uric acid	renin	MESH:D014527	5972	Chemical	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Plasma renin activity , blood uric_acid and plasma volume in pregnancy-induced hypertension .
6361757	0	uric_acid	29,38	renin	7,12	uric acid	renin	MESH:D014527	5972	Chemical	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Plasma renin activity , blood uric_acid and plasma volume in pregnancy-induced hypertension .
6367368	0	uric_acid	39,48	renin	60,65	uric acid	renin	MESH:D014527	5972	Chemical	Gene	START_ENTITY|nmod|type type|compound|END_ENTITY	Increased plasma vasopressin and serum uric_acid in the low renin type of essential hypertension .
26511169	0	uric_acid	15,24	tumour_necrosis_factor-a	76,100	uric acid	tumour necrosis factor-a	MESH:D014527	7124	Chemical	Gene	START_ENTITY|ccomp|associated associated|nmod|expression expression|nmod|END_ENTITY	Maternal serum uric_acid concentration is associated with the expression of tumour_necrosis_factor-a and intercellular_adhesion_molecule-1 in patients with preeclampsia .
16385546	0	uric_acid	64,73	urate_transporter_1	25,44	uric acid	urate transporter 1	MESH:D014527	116085	Chemical	Gene	START_ENTITY|nsubj|Association Association|nmod|END_ENTITY	Association of the human urate_transporter_1 with reduced renal uric_acid excretion and hyperuricemia in a German Caucasian population .
7357749	0	uric_acid	17,26	uricase	32,39	uric acid	uricase	MESH:D014527	391051	Chemical	Gene	Determination|nmod|START_ENTITY Determination|nmod|END_ENTITY	Determination of uric_acid with uricase and peroxidase .
23091148	0	uric_acid	28,37	xanthine_oxidoreductase	69,92	uric acid	xanthine oxidoreductase	MESH:D014527	7498	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|activity activity|amod|END_ENTITY	The effects of allopurinol , uric_acid , and inosine administration on xanthine_oxidoreductase activity and uric_acid concentrations in broilers .
10833526	0	uridine	25,32	apolipoprotein_B	56,72	uridine	apolipoprotein B	MESH:D014529	338	Chemical	Gene	START_ENTITY|nmod|mRNA mRNA|compound|END_ENTITY	Induction of cytidine to uridine editing on cytoplasmic apolipoprotein_B mRNA by overexpressing APOBEC-1 .
3911515	0	uridine	62,69	epidermal_growth_factor	23,46	uridine	epidermal growth factor	MESH:D014529	1950	Chemical	Gene	phosphorylation|amod|START_ENTITY END_ENTITY|nmod|phosphorylation	-LSB- Stimulating action of epidermal_growth_factor and insulin on uridine phosphorylation in 3T3 and 3T6 cells -RSB- .
6518414	0	uridine	29,36	erythropoietin	11,25	uridine	erythropoietin	MESH:D014529	280784(Tax:9913)	Chemical	Gene	metabolism|amod|START_ENTITY Effects|nmod|metabolism Effects|nmod|END_ENTITY	Effects of erythropoietin on uridine metabolism in cell cultures of fetal calf liver .
2550217	0	uridine	10,17	galactose-1-phosphate_uridyltransferase	29,68	uridine	galactose-1-phosphate uridyltransferase	MESH:D014529	2592	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of uridine on hepatic galactose-1-phosphate_uridyltransferase .
16397116	0	uridine	14,21	tumor_necrosis_factor-alpha	55,82	uridine	tumor necrosis factor-alpha	MESH:D014529	21926(Tax:10090)	Chemical	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Modulation of uridine phosphorylase gene expression by tumor_necrosis_factor-alpha enhances the antiproliferative activity of the capecitabine intermediate 5 ' - deoxy-5-fluorouridine in breast_cancer cells .
20544543	0	uridine	75,82	tumor_necrosis_factor-alpha	100,127	uridine	tumor necrosis factor-alpha	MESH:D014529	7124	Chemical	Gene	phosphorylase|amod|START_ENTITY induction|nmod|phosphorylase required|nmod|induction required|nmod|END_ENTITY	Activation of Stat1 , IRF-1 , and NF-kappaB is required for the induction of uridine phosphorylase by tumor_necrosis_factor-alpha and interferon-gamma .
9806225	0	uridine_diphosphate	22,41	UDP-glucuronosyltransferase	45,72	uridine diphosphate	UDP-glucuronosyltransferase	MESH:D014530	24862(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Inhibitory effects of uridine_diphosphate on UDP-glucuronosyltransferase .
22299209	0	uridine_glucuronosyl	14,34	UGT1A1	52,58	uridine glucuronosyl	UGT1A1	null	54658	Chemical	Gene	mutations|amod|START_ENTITY mutations|appos|END_ENTITY	Prevalence of uridine_glucuronosyl transferase 1A1 -LRB- UGT1A1 -RRB- mutations in Malay neonates with severe jaundice .
8069469	0	uridine_monophosphate	16,37	UMPS	48,52	uridine monophosphate	UMPS	MESH:D014542	102399012	Chemical	Gene	synthase|amod|START_ENTITY Localization|nmod|synthase Localization|appos|END_ENTITY	Localization of uridine_monophosphate synthase -LRB- UMPS -RRB- gene to river_buffalo chromosomes by FISH .
2021937	0	uridine_nucleotides	20,39	deoxycytidine_kinase	61,81	uridine nucleotides	deoxycytidine kinase	MESH:D014500	1633	Chemical	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	A critical role for uridine_nucleotides in the regulation of deoxycytidine_kinase and the concentration dependence of 1-beta-D-arabinofuranosylcytosine phosphorylation in human leukemia cells .
10545778	0	uridine_triphosphate	59,79	IL-6	43,47	uridine triphosphate	IL-6	MESH:D014544	16193(Tax:10090)	Chemical	Gene	release|nmod|START_ENTITY release|compound|END_ENTITY	Potentiation of lipopolysaccharide-induced IL-6 release by uridine_triphosphate in macrophages : cross-interaction with cyclooxygenase-2-dependent prostaglandin_E -LRB- 2 -RRB- production .
9200705	0	uridine_triphosphate	77,97	deoxycytidine_kinase	26,46	uridine triphosphate	deoxycytidine kinase	MESH:D014544	1633	Chemical	Gene	START_ENTITY|nsubj|analysis analysis|nmod|END_ENTITY	Kinetic analysis of human deoxycytidine_kinase with the true phosphate donor uridine_triphosphate .
8919038	0	urocanic_acid	78,91	CD80	14,18	urocanic acid	CD80	MESH:D014560	941	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|Expression Expression|nmod|END_ENTITY	Expression of CD80 -LRB- B7/BB -1 -RRB- and CD28 in human white blood cells treated with urocanic_acid .
8174759	0	uroporphyrin_I	54,68	delta-Aminolevulinic_acid_dehydratase	0,37	uroporphyrin I	delta-Aminolevulinic acid dehydratase	MESH:C034103	210	Chemical	Gene	inactivation|nmod|START_ENTITY inactivation|amod|END_ENTITY	delta-Aminolevulinic_acid_dehydratase inactivation by uroporphyrin_I in light and darkness .
1669450	0	uroporphyrin_I	118,132	uroporphyrinogen_decarboxylase	84,114	uroporphyrin I	uroporphyrinogen decarboxylase	MESH:C034103	7389	Chemical	Gene	evidence|nmod|START_ENTITY evidence|nmod|END_ENTITY	Further evidence on the photodynamic and the novel non-photodynamic inactivation of uroporphyrinogen_decarboxylase by uroporphyrin_I .
2283671	0	uroporphyrinogen	57,73	cytochrome_P-450	27,43	uroporphyrinogen	cytochrome P-450	CHEBI:27258	25251(Tax:10116)	Chemical	Gene	oxidation|compound|START_ENTITY oxidation|amod|END_ENTITY	Role of inducer binding in cytochrome_P-450 IA2-mediated uroporphyrinogen oxidation .
24034919	0	ursodeoxycholic_acid	12,32	MDR3	55,59	ursodeoxycholic acid	MDR3	MESH:D014580	5244	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of ursodeoxycholic_acid on mRNA expression of MDR3 and FXR in infants with cholestatic_hepatitis -RSB- .
19493473	0	ursodeoxycholic_acid	10,30	TGF_beta1	34,43	ursodeoxycholic acid	TGF beta1	MESH:D014580	59086(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of ursodeoxycholic_acid on TGF_beta1 / Smad signaling pathway in rat hepatic stellate cells .
16378305	0	ursodeoxycholic_acid	14,34	epidermal_growth_factor	48,71	ursodeoxycholic acid	epidermal growth factor	MESH:D014580	1950	Chemical	Gene	treatment|amod|START_ENTITY effect|nmod|treatment effect|nmod|END_ENTITY	The effect of ursodeoxycholic_acid treatment on epidermal_growth_factor in patients with bile_reflux_gastritis .
11577102	0	ursodeoxycholic_acid	109,129	glucocorticoid_receptor	29,52	ursodeoxycholic acid	glucocorticoid receptor	MESH:D014580	2908	Chemical	Gene	transcription|nmod|START_ENTITY transcription|nsubj|modulation modulation|nmod|END_ENTITY	Functional modulation of the glucocorticoid_receptor and suppression of NF-kappaB-dependent transcription by ursodeoxycholic_acid .
8568266	0	ursodeoxycholic_acid	64,84	glucocorticoid_receptor	37,60	ursodeoxycholic acid	glucocorticoid receptor	MESH:D014580	100763961	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Ligand-independent activation of the glucocorticoid_receptor by ursodeoxycholic_acid .
17456043	0	ursolic_acid	39,51	PLA2	20,24	ursolic acid	PLA2	MESH:C005466	5320	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Group IIA secretory PLA2 inhibition by ursolic_acid : a potent anti-inflammatory molecule .
22883405	0	ursolic_acid	12,24	c-Cbl-associated_protein	28,52	ursolic acid	c-Cbl-associated protein	MESH:C005466	20411(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effects of ursolic_acid on c-Cbl-associated_protein expression in 3T3-L1 adipocytes with insulin resistance -RSB- .
11848513	0	ursolic_acid	55,67	caspase-3	14,23	ursolic acid	caspase-3	MESH:C005466	836	Chemical	Gene	process|nmod|START_ENTITY Activation|nmod|process Activation|nmod|protease protease|amod|END_ENTITY	Activation of caspase-3 protease during the process of ursolic_acid and its derivative-induced apoptosis .
16570804	0	ursolic_acid	11,23	caspase-3	27,36	ursolic acid	caspase-3	MESH:C005466	836	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effect of ursolic_acid on caspase-3 and PARP expression of human MCF-7 cells -RSB- .
17727365	0	ursolic_acid	23,35	peroxisome_proliferator-activated_receptor-alpha	145,193	ursolic acid	peroxisome proliferator-activated receptor-alpha	MESH:C005466	19013(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|function function|nmod|END_ENTITY	Simultaneous effect of ursolic_acid and oleanolic_acid on epidermal permeability barrier function and epidermal keratinocyte differentiation via peroxisome_proliferator-activated_receptor-alpha .
8076432	0	uterine	27,34	angiotensin_II	50,64	uterine	angiotensin II	null	24179(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Differential regulation of uterine and glomerular angiotensin_II receptors in normal and hypertensive pregnancy in the rat .
3021757	0	uteroferrin	30,41	transferrin	45,56	uteroferrin	transferrin	null	7018	Chemical	Gene	transfer|nmod|START_ENTITY transfer|nmod|END_ENTITY	Absence of iron transfer from uteroferrin to transferrin .
23249537	0	utp	54,57	P2Y2	49,53	utp	P2Y2	MESH:D014544	29597(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Control of P2X3 channel function by metabotropic P2Y2 utp receptors in primary sensory neurons .
23924683	0	valacyclovir	85,97	peptide_transporter_1	10,31	valacyclovir	peptide transporter 1	MESH:C084555	56643(Tax:10090)	Chemical	Gene	Impact|nmod|START_ENTITY Impact|nmod|END_ENTITY	Impact of peptide_transporter_1 on the intestinal absorption and pharmacokinetics of valacyclovir after oral dose escalation in wild-type and PepT1 knockout mice .
10715145	0	valdecoxib	56,66	COX-2	104,109	valdecoxib	COX-2	MESH:C406224	4513	Chemical	Gene	benzenesulfonamide|appos|START_ENTITY 4|dep|benzenesulfonamide 4|dep|inhibitor inhibitor|nmod|END_ENTITY	4 - -LSB- 5-Methyl-3-phenylisoxazol-4-yl -RSB- - _ benzenesulfonamide , valdecoxib : a potent and selective inhibitor of COX-2 .
12590029	0	valdecoxib	30,40	COX-2	4,9	valdecoxib	COX-2	MESH:C406224	4513	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|specific specific|amod|END_ENTITY	The COX-2 specific inhibitor , valdecoxib , is an effective , opioid-sparing analgesic in patients undergoing total knee arthroplasty .
12642477	0	valdecoxib	54,64	COX-2	37,42	valdecoxib	COX-2	MESH:C406224	17709(Tax:10090)	Chemical	Gene	Pharmacokinetics|amod|START_ENTITY Pharmacokinetics|nmod|END_ENTITY	Pharmacokinetics and metabolism of a COX-2 inhibitor , valdecoxib , in mice .
12751271	0	valdecoxib	31,41	COX-2	4,9	valdecoxib	COX-2	MESH:C406224	4513	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|selective selective|amod|END_ENTITY	The COX-2 selective inhibitor , valdecoxib , does not impair platelet function in the elderly : results of a randomized controlled trial .
15339324	0	valdecoxib	100,110	COX-2	73,78	valdecoxib	COX-2	MESH:C406224	4513	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|selective selective|amod|END_ENTITY	Reduced incidence of upper_gastrointestinal_ulcer_complications with the COX-2 selective inhibitor , valdecoxib .
15494548	3	valdecoxib	418,428	COX-2	494,499	valdecoxib	COX-2	MESH:C406224	4513	Chemical	Gene	inhibitor|appos|START_ENTITY properties|nmod|inhibitor properties|nmod|END_ENTITY	We report here the pharmacological properties of a third selective COX-2 inhibitor , valdecoxib , which is the most potent and in vitro selective of the marketed COX-2 inhibitors that we have studied .
15887009	0	valdecoxib	78,88	COX-2	102,107	valdecoxib	COX-2	MESH:C406224	4513	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	The effect of mild and moderate hepatic_impairment on the pharmacokinetics of valdecoxib , a selective COX-2 inhibitor .
17525166	0	valdecoxib	129,139	COX-2	103,108	valdecoxib	COX-2	MESH:C406224	4513	Chemical	Gene	START_ENTITY|amod|selective selective|amod|END_ENTITY	Utility and sensitivity of the sore throat_pain model : results of a randomized controlled trial on the COX-2 selective inhibitor valdecoxib .
17687276	0	valdecoxib	73,83	COX-2	39,44	valdecoxib	COX-2	MESH:C406224	5743	Chemical	Gene	concentration|nmod|START_ENTITY concentration|compound|END_ENTITY	Intravenous parecoxib rapidly leads to COX-2 inhibitory concentration of valdecoxib in the central nervous system .
12167567	0	valdecoxib	54,64	cyclooxygenase-2	26,42	valdecoxib	cyclooxygenase-2	MESH:C406224	5743	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Disposition of a specific cyclooxygenase-2 inhibitor , valdecoxib , in human .
12218521	0	valdecoxib	35,45	cyclooxygenase-2	53,69	valdecoxib	cyclooxygenase-2	MESH:C406224	5743	Chemical	Gene	dose|nmod|START_ENTITY dose|appos|inhibitor inhibitor|amod|END_ENTITY	A single preoperative oral dose of valdecoxib , a new cyclooxygenase-2 specific inhibitor , relieves post-oral surgery or bunionectomy pain .
15369392	0	valdecoxib	52,62	cyclooxygenase-2	73,89	valdecoxib	cyclooxygenase-2	MESH:C406224	5743	Chemical	Gene	analogues|nmod|START_ENTITY synthesis|nmod|analogues synthesis|dep|selectivity selectivity|amod|END_ENTITY	Novel synthesis of 3,4-diarylisoxazole analogues of valdecoxib : reversal cyclooxygenase-2 selectivity by sulfonamide group removal .
16153836	0	valdecoxib	113,123	cyclooxygenase-2	164,180	valdecoxib	cyclooxygenase-2	MESH:C406224	5743	Chemical	Gene	analogue|nmod|START_ENTITY benzenesulfonamide|appos|analogue Synthesis|dep|benzenesulfonamide Synthesis|nmod|radiotracer radiotracer|nmod|END_ENTITY	Synthesis of 4 - -LRB- 5 - -LSB- 18F -RSB- fluoromethyl-3-phenylisoxazol-4-yl -RRB- benzenesulfonamide , a new -LSB- 18F -RSB- fluorinated analogue of valdecoxib , as a potential radiotracer for imaging cyclooxygenase-2 with positron emission tomography .
19156843	0	valerenic_acid	44,58	Mrp2	100,104	valerenic acid	Mrp2	MESH:C037133	25303(Tax:10116)	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|dep|role role|nmod|END_ENTITY	Hepatic metabolism and biliary excretion of valerenic_acid in isolated perfused rat livers : role of Mrp2 -LRB- Abcc2 -RRB- .
12967587	0	valeryl_salicylate	11,29	COX-1	33,38	valeryl salicylate	COX-1	MESH:C401835	19224(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Effects of valeryl_salicylate , a COX-1 inhibitor , on models of acute inflammation in mice .
7872783	0	valerylsalicylic_acid	84,105	prostaglandin_endoperoxide_synthase-1	24,61	valerylsalicylic acid	prostaglandin endoperoxide synthase-1	MESH:C117223	19224(Tax:10090)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Selective inhibition of prostaglandin_endoperoxide_synthase-1 -LRB- cyclooxygenase-1 -RRB- by valerylsalicylic_acid .
10824137	0	valganciclovir	13,27	PEPT1	77,82	valganciclovir	PEPT1	MESH:C121677	6564	Chemical	Gene	Transport|nmod|START_ENTITY Transport|nmod|END_ENTITY	Transport of valganciclovir , a ganciclovir prodrug , via peptide transporters PEPT1 and PEPT2 .
6434351	0	valine	109,115	dihydrofolate_reductase	141,164	valine	dihydrofolate reductase	CHEBI:27266	1719	Chemical	Gene	residues|amod|START_ENTITY residues|nmod|END_ENTITY	The combined use of selective deuteration and double resonance experiments in assigning the 1H resonances of valine and tyrosine residues of dihydrofolate_reductase .
7015073	0	valine	7,13	insulin	96,103	valine	insulin	CHEBI:27266	3630	Chemical	Gene	disposal|compound|START_ENTITY disposal|dep|evidence evidence|nmod|resistance resistance|compound|END_ENTITY	Normal valine disposal in obese subjects with impaired_glucose_disposal : evidence for selective insulin resistance .
16023344	0	valine_aspartyl_ketones	78,101	caspase_3	105,114	valine aspartyl ketones	caspase 3	null	836	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Lipophilic versus hydrogen-bonding effect in P3 on potency and selectivity of valine_aspartyl_ketones as caspase_3 inhibitors .
25973343	0	valproate	36,45	CD20	57,61	valproate	CD20	MESH:D014635	54474	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Pharmacologically relevant doses of valproate upregulate CD20 expression in three diffuse large B-cell_lymphoma patients in vivo .
15269271	0	valproate	16,25	ERK	35,38	valproate	ERK	MESH:D014635	5594	Chemical	Gene	promotes|nsubj|START_ENTITY promotes|dobj|growth growth|compound|END_ENTITY	Mood stabilizer valproate promotes ERK pathway-dependent cortical neuronal growth and neurogenesis .
18677583	0	valproate	72,81	ERK	28,31	valproate	ERK	MESH:D014635	5594	Chemical	Gene	Bcl-2|nmod|START_ENTITY induction|nmod|Bcl-2 Evidence|nmod|induction Evidence|nmod|END_ENTITY	Evidence for involvement of ERK , PI3K , and RSK in induction of Bcl-2 by valproate .
23994577	0	valproate	30,39	NPY	87,90	valproate	NPY	MESH:D014635	4852	Chemical	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Therapeutic concentrations of valproate but not amitriptyline increase neuropeptide_Y -LRB- NPY -RRB- expression in the human SH-SY5Y neuroblastoma cell line .
16192836	0	valproate	10,19	interleukin-6	40,53	valproate	interleukin-6	MESH:D014635	3569	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of valproate on plasma levels of interleukin-6 in healthy male humans .
22645062	0	valproate	140,149	neuropeptide_Y	15,29	valproate	neuropeptide Y	MESH:D014635	4852	Chemical	Gene	treated|nmod|START_ENTITY children|acl|treated thickness|nmod|children thickness|advmod|END_ENTITY	Plasma leptin , neuropeptide_Y , ghrelin , and adiponectin levels and carotid artery intima media thickness in epileptic children treated with valproate .
23994577	0	valproate	30,39	neuropeptide_Y	71,85	valproate	neuropeptide Y	MESH:D014635	4852	Chemical	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Therapeutic concentrations of valproate but not amitriptyline increase neuropeptide_Y -LRB- NPY -RRB- expression in the human SH-SY5Y neuroblastoma cell line .
24039965	0	valproate	10,19	neuropeptide_Y	46,60	valproate	neuropeptide Y	MESH:D014635	24604(Tax:10116)	Chemical	Gene	treatment|compound|START_ENTITY increases|nsubj|treatment increases|dobj|expression expression|compound|END_ENTITY	Long-term valproate treatment increases brain neuropeptide_Y expression and decreases seizure expression in a genetic rat model of absence_epilepsy .
18622267	0	valproic_acid	47,60	FMR1	34,38	valproic acid	FMR1	MESH:D014635	2332	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Modest reactivation of the mutant FMR1 gene by valproic_acid is accompanied by histone modifications but not DNA demethylation .
17428471	0	valproic_acid	49,62	Gadd45a	0,7	valproic acid	Gadd45a	MESH:D014635	13197(Tax:10090)	Chemical	Gene	induced|nmod|START_ENTITY gene|acl|induced END_ENTITY|appos|gene	Gadd45a , the gene induced by the mood stabilizer valproic_acid , regulates neurite outgrowth through JNK and the substrate paxillin in N1E-115 neuroblastoma cells .
12840003	0	valproic_acid	34,47	HDAC2	95,100	valproic acid	HDAC2	MESH:D014635	3066	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|degradation degradation|nmod|END_ENTITY	The histone deacetylase inhibitor valproic_acid selectively induces proteasomal degradation of HDAC2 .
12088081	0	valproic_acid	73,86	Insulin	0,7	valproic acid	Insulin	MESH:D014635	3630	Chemical	Gene	therapy|nmod|START_ENTITY gain|nmod|therapy girls|acl:relcl|gain resistance|nmod|girls resistance|compound|END_ENTITY	Insulin resistance in epileptic girls who gain weight after therapy with valproic_acid .
15179681	0	valproic_acid	62,75	Insulin	1,8	valproic acid	Insulin	MESH:D014635	3630	Chemical	Gene	-RSB-|amod|START_ENTITY treatment|nmod|-RSB- resistance|nmod|treatment resistance|nsubj|END_ENTITY	-LSB- Insulin resistance in epileptic patients during treatment of valproic_acid -RSB- .
25286962	0	valproic_acid	34,47	Insulin	0,7	valproic acid	Insulin	MESH:D014635	3630	Chemical	Gene	patients|nmod|START_ENTITY resistance|nmod|patients resistance|compound|END_ENTITY	Insulin resistance in patients on valproic_acid : relation to adiponectin .
16344528	0	valproic_acid	68,81	Leptin	0,6	valproic acid	Leptin	MESH:D014635	3952	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|END_ENTITY	Leptin , ghrelin , and adiponectin in epileptic patients treated with valproic_acid .
18165917	0	valproic_acid	87,100	MDR1	15,19	valproic acid	MDR1	MESH:D014635	5243	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|Association Association|nmod|polymorphism polymorphism|compound|END_ENTITY	Association of MDR1 C3435T polymorphism with bipolar_disorder in patients treated with valproic_acid .
24909617	0	valproic_acid	64,77	MT2	47,50	valproic acid	MT2	MESH:D014635	689415(Tax:10116)	Chemical	Gene	receptors|nmod|START_ENTITY receptors|compound|END_ENTITY	Regional upregulation of hippocampal melatonin MT2 receptors by valproic_acid : therapeutic implications for Alzheimer 's _ disease .
25152329	0	valproic_acid	48,61	Nrf2	8,12	valproic acid	Nrf2	MESH:D014635	18024(Tax:10090)	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Role of Nrf2 activation and NF-kB inhibition in valproic_acid induced hepatotoxicity and in diammonium_glycyrrhizinate induced protection in mice .
25454122	0	valproic_acid	91,104	Nrf2	34,38	valproic acid	Nrf2	MESH:D014635	18024(Tax:10090)	Chemical	Gene	development|acl|START_ENTITY development|nmod|mice mice|amod|END_ENTITY	Altered behavioral development in Nrf2 knockout mice following early postnatal exposure to valproic_acid .
19304516	0	valproic_acid	11,24	P27	46,49	valproic acid	P27	MESH:D014635	10534	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of valproic_acid on the expression of P27 -LRB- Kip1 -RRB- and P170 and drug resistance of HL-60 / HT cells -RSB- .
20551479	0	valproic_acid	109,122	SMN	18,21	valproic acid	SMN	MESH:D014635	6606	Chemical	Gene	treatment|nmod|START_ENTITY effects|nmod|treatment Quantification|dep|effects Quantification|nmod|protein protein|compound|END_ENTITY	Quantification of SMN protein in leucocytes from spinal_muscular_atrophy patients : effects of treatment with valproic_acid .
18838507	0	valproic_acid	38,51	UGT1A4	122,128	valproic acid	UGT1A4	MESH:D014635	54657	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of aging on glucuronidation of valproic_acid in human liver microsomes and the role of UDP-glucuronosyltransferase UGT1A4 , UGT1A8 , and UGT1A10 .
26303110	0	valproic_acid	13,26	UGT1A4	61,67	valproic acid	UGT1A4	MESH:D014635	54657	Chemical	Gene	concentration|amod|START_ENTITY concentration|nmod|___ ___|compound|END_ENTITY	Influence of valproic_acid concentration and polymorphism of UGT1A4 * 3 , UGT2B7 -161 C ___ > ___ T and UGT2B7 * 2 on serum concentration of lamotrigine in Chinese epileptic children .
26303110	0	valproic_acid	13,26	UGT1A4	61,67	valproic acid	UGT1A4	MESH:D014635	54657	Chemical	Gene	concentration|amod|START_ENTITY concentration|nmod|___ ___|compound|END_ENTITY	Influence of valproic_acid concentration and polymorphism of UGT1A4 * 3 , UGT2B7 -161 C ___ > ___ T and UGT2B7 * 2 on serum concentration of lamotrigine in Chinese epileptic children .
19458381	0	valproic_acid	52,65	biotinidase	6,17	valproic acid	biotinidase	MESH:D014635	686	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|activity activity|compound|END_ENTITY	Serum biotinidase activity in children treated with valproic_acid and carbamazepine .
26518464	0	valproic_acid	9,22	c-Fos	51,56	valproic acid	c-Fos	MESH:D014635	314322(Tax:10116)	Chemical	Gene	exposure|amod|START_ENTITY disrupts|nsubj|exposure disrupts|dobj|expression expression|amod|END_ENTITY	Prenatal valproic_acid exposure disrupts tonotopic c-Fos expression in the rat brainstem .
27094734	0	valproic_acid	9,22	c-Fos	51,56	valproic acid	c-Fos	MESH:D014635	314322(Tax:10116)	Chemical	Gene	exposure|amod|START_ENTITY disrupts|nsubj|exposure disrupts|dobj|expression expression|amod|END_ENTITY	Prenatal valproic_acid exposure disrupts tonotopic c-Fos expression in the rat brainstem .
11736863	0	valproic_acid	23,36	cytochrome_P450_2C9	115,134	valproic acid	cytochrome P450 2C9	MESH:D014635	1559	Chemical	Gene	isoforms|amod|START_ENTITY evaluation|nmod|isoforms inhibition|nmod|evaluation inhibition|nmod|END_ENTITY	In vitro evaluation of valproic_acid as an inhibitor of human cytochrome P450 isoforms : preferential inhibition of cytochrome_P450_2C9 -LRB- CYP2C9 -RRB- .
17516991	0	valproic_acid	21,34	cytochrome_P450_2C9	38,57	valproic acid	cytochrome P450 2C9	MESH:D014635	1559	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Inhibitory effect of valproic_acid on cytochrome_P450_2C9 activity in epilepsy patients .
8185653	0	valproic_acid	61,74	glutathione_reductase	36,57	valproic acid	glutathione reductase	MESH:D014635	2936	Chemical	Gene	evidence|nmod|START_ENTITY evidence|nmod|END_ENTITY	No evidence for inhibition of human glutathione_reductase by valproic_acid .
14985358	0	valproic_acid	46,59	histone_deacetylase	14,33	valproic acid	histone deacetylase	MESH:D014635	9734	Chemical	Gene	blocks|amod|START_ENTITY activity|nmod|blocks activity|amod|END_ENTITY	Inhibition of histone_deacetylase activity by valproic_acid blocks adipogenesis .
16123451	0	valproic_acid	86,99	histone_deacetylase	111,130	valproic acid	histone deacetylase	MESH:D014635	9734	Chemical	Gene	cells|nmod|START_ENTITY human_cytomegalovirus|nmod|cells replication|nmod|human_cytomegalovirus depends|nsubj|replication depends|nmod|inhibition inhibition|amod|END_ENTITY	Increased replication of human_cytomegalovirus in retinal pigment epithelial cells by valproic_acid depends on histone_deacetylase inhibition .
17566732	0	valproic_acid	22,35	histone_deacetylase	54,73	valproic acid	histone deacetylase	MESH:D014635	9734	Chemical	Gene	GRP78|nmod|START_ENTITY Induction|nmod|GRP78 dependent|nsubj|Induction dependent|nmod|inhibition inhibition|amod|END_ENTITY	Induction of GRP78 by valproic_acid is dependent upon histone_deacetylase inhibition .
18294844	0	valproic_acid	30,43	histone_deacetylase	58,77	valproic acid	histone deacetylase	MESH:D014635	9734	Chemical	Gene	derivatives|nmod|START_ENTITY sulfurated|dobj|derivatives sulfurated|nmod|activity activity|amod|END_ENTITY	New sulfurated derivatives of valproic_acid with enhanced histone_deacetylase inhibitory activity .
18657224	0	valproic_acid	34,47	histone_deacetylase	4,23	valproic acid	histone deacetylase	MESH:D014635	9734	Chemical	Gene	START_ENTITY|nsubj|inhibitor inhibitor|amod|END_ENTITY	The histone_deacetylase inhibitor valproic_acid alters growth properties of renal_cell_carcinoma in vitro and in vivo .
18765532	0	valproic_acid	65,78	histone_deacetylase	35,54	valproic acid	histone deacetylase	MESH:D014635	9734	Chemical	Gene	START_ENTITY|nsubj|sensitization sensitization|nmod|inhibitor inhibitor|amod|END_ENTITY	Postradiation sensitization of the histone_deacetylase inhibitor valproic_acid .
20306194	0	valproic_acid	34,47	histone_deacetylase	4,23	valproic acid	histone deacetylase	MESH:D014635	9734	Chemical	Gene	START_ENTITY|nsubj|inhibitor inhibitor|amod|END_ENTITY	The histone_deacetylase inhibitor valproic_acid sensitizes human and canine osteosarcoma to doxorubicin .
21966390	0	valproic_acid	45,58	histone_deacetylase	15,34	valproic acid	histone deacetylase	MESH:D014635	9734	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Effects of the histone_deacetylase inhibitor valproic_acid on human pericytes in vitro .
23353839	0	valproic_acid	40,53	histone_deacetylase	10,29	valproic acid	histone deacetylase	MESH:D014635	9734	Chemical	Gene	START_ENTITY|nsubj|Impact Impact|nmod|inhibitor inhibitor|amod|END_ENTITY	Impact of histone_deacetylase inhibitor valproic_acid on the anticancer effect of etoposide on neuroblastoma cells .
21968575	0	valproic_acid	19,32	histone_deacetylase_8	49,70	valproic acid	histone deacetylase 8	MESH:D014635	55869	Chemical	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Exploration of the valproic_acid binding site on histone_deacetylase_8 using docking and molecular dynamic simulations .
12370846	0	valproic_acid	73,86	insulin	31,38	valproic acid	insulin	MESH:D014635	3630	Chemical	Gene	therapy|amod|START_ENTITY Increase|nmod|therapy Increase|nmod|levels levels|compound|END_ENTITY	Increase in postprandial serum insulin levels in epileptic patients with valproic_acid therapy .
22155806	0	valproic_acid	64,77	insulin	8,15	valproic acid	insulin	MESH:D014635	3630	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|END_ENTITY	Fasting insulin and HOMA-index changes in patients treated with valproic_acid .
23182413	0	valproic_acid	80,93	insulin	10,17	valproic acid	insulin	MESH:D014635	3630	Chemical	Gene	treated|nmod|START_ENTITY patients|acl|treated parameters|nmod|patients parameters|nsubj|resistance resistance|compound|END_ENTITY	The novel insulin resistance parameters RBP4 and GLP-1 in patients treated with valproic_acid : just a sidestep ?
21430231	0	valproic_acid	106,119	isovaleryl-CoA_dehydrogenase	8,36	valproic acid	isovaleryl-CoA dehydrogenase	MESH:D014635	3712	Chemical	Gene	metabolism|nmod|START_ENTITY Role|nmod|metabolism Role|nmod|END_ENTITY	Role of isovaleryl-CoA_dehydrogenase and short_branched-chain_acyl-CoA_dehydrogenase in the metabolism of valproic_acid : implications for the branched-chain amino_acid oxidation pathway .
10408570	0	valproic_acid	78,91	leptin	6,12	valproic acid	leptin	MESH:D014635	3952	Chemical	Gene	therapy|nmod|START_ENTITY gain|nmod|therapy patients|acl:relcl|gain Serum|nmod|patients Serum|dobj|changes changes|compound|END_ENTITY	Serum leptin changes in epileptic patients who gain weight after therapy with valproic_acid .
25627160	0	valproic_acid	83,96	mTOR	10,14	valproic acid	mTOR	MESH:D014635	21977(Tax:10090)	Chemical	Gene	exposed|xcomp|START_ENTITY exposed|nsubj|END_ENTITY	Decreased mTOR signaling pathway in human idiopathic autism and in rats exposed to valproic_acid .
22923031	0	valproic_acid	53,66	matrix_metalloproteinase-9	18,44	valproic acid	matrix metalloproteinase-9	MESH:D014635	4318	Chemical	Gene	mRNA|nmod|START_ENTITY mRNA|amod|END_ENTITY	Downregulation of matrix_metalloproteinase-9 mRNA by valproic_acid plays a role in inhibiting the shedding of MHC class I-related molecules A and B on the surface of human osteosarcoma cells .
2516508	0	valproic_acid	43,56	pseudocholinesterase	9,29	valproic acid	pseudocholinesterase	MESH:D014635	590	Chemical	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Probable pseudocholinesterase induction by valproic_acid , carbamazepine and phenytoin leading to increased serum aspirin-esterase activity in epileptics .
22363677	0	valproic_acid	57,70	tissue-type_plasminogen_activator	95,128	valproic acid	tissue-type plasminogen activator	MESH:D014635	5327	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Role of histone acetylation in the stimulatory effect of valproic_acid on vascular endothelial tissue-type_plasminogen_activator expression .
26131133	0	valsartan	10,19	ACAT-1	23,29	valsartan	ACAT-1	MESH:C081489	100350797(Tax:9986)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of valsartan on ACAT-1 and PPAR-y expression in intima with carotid artery endothelial_balloon_injury in rabbit .
15452025	0	valsartan	81,90	AT1_receptor	59,71	valsartan	AT1 receptor	MESH:C081489	11610(Tax:10090)	Chemical	Gene	blocker|appos|START_ENTITY blocker|amod|END_ENTITY	Fluvastatin enhances the inhibitory effects of a selective AT1_receptor blocker , valsartan , on atherosclerosis .
21293390	0	valsartan	47,56	AT1_receptor	25,37	valsartan	AT1 receptor	MESH:C081489	11610(Tax:10090)	Chemical	Gene	blocker|appos|START_ENTITY blocker|amod|END_ENTITY	Temporary treatment with AT1_receptor blocker , valsartan , from early stage of hypertension prevented vascular_remodeling .
10028951	0	valsartan	64,73	Angiotensin_II	0,14	valsartan	Angiotensin II	MESH:C081489	183	Chemical	Gene	experience|nmod|START_ENTITY antagonism|dep|experience antagonism|compound|END_ENTITY	Angiotensin_II antagonism in clinical practice : experience with valsartan .
10028952	0	valsartan	41,50	Angiotensin_II	0,14	valsartan	Angiotensin II	MESH:C081489	183	Chemical	Gene	antagonism|dep|START_ENTITY antagonism|compound|END_ENTITY	Angiotensin_II antagonism and the heart : valsartan in left ventricular_hypertrophy .
10449888	0	valsartan	41,50	Angiotensin_II	0,14	valsartan	Angiotensin II	MESH:C081489	183	Chemical	Gene	antagonism|dep|START_ENTITY antagonism|compound|END_ENTITY	Angiotensin_II antagonism and the heart : valsartan in left ventricular_hypertrophy .
12970329	0	valsartan	32,41	Angiotensin_II	0,14	valsartan	Angiotensin II	MESH:C081489	183	Chemical	Gene	suppresses|compound|START_ENTITY suppresses|compound|END_ENTITY	Angiotensin_II receptor blocker valsartan suppresses reactive_oxygen_species generation in leukocytes , nuclear factor-kappa B , in mononuclear cells of normal subjects : evidence of an antiinflammatory action .
11561228	0	valsartan	59,68	Angiotensin_II_type_1_receptor	0,30	valsartan	Angiotensin II type 1 receptor	MESH:C081489	185	Chemical	Gene	mg|dobj|START_ENTITY mg|nsubj|blockade blockade|amod|END_ENTITY	Angiotensin_II_type_1_receptor blockade with 80 and 160 mg valsartan in healthy , normotensive subjects .
12688405	0	valsartan	40,49	Angiotensin_II_type_1_receptor	0,30	valsartan	Angiotensin II type 1 receptor	MESH:C081489	81638(Tax:10116)	Chemical	Gene	blocker|appos|START_ENTITY blocker|amod|END_ENTITY	Angiotensin_II_type_1_receptor blocker , valsartan , prevented cardiac_fibrosis in rat cardiomyopathy after autoimmune_myocarditis .
10232502	0	valsartan	47,56	angiotensin_II	20,34	valsartan	angiotensin II	MESH:C081489	183	Chemical	Gene	antagonists|dobj|START_ENTITY antagonists|nsubj|comparison comparison|nmod|END_ENTITY	A comparison of the angiotensin_II antagonists valsartan and losartan in the treatment of essential_hypertension .
10463202	0	valsartan	45,54	angiotensin_II	19,33	valsartan	angiotensin II	MESH:C081489	183	Chemical	Gene	START_ENTITY|nsubj|Treatment Treatment|nmod|antagonist antagonist|amod|END_ENTITY	Treatment with the angiotensin_II antagonist valsartan in patients with chronic_renal_failure and hypertension .
10871310	0	valsartan	87,96	angiotensin_II	56,70	valsartan	angiotensin II	MESH:C081489	24179(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|actions actions|nmod|END_ENTITY	Differential inhibition of the prejunctional actions of angiotensin_II in rat atria by valsartan , irbesartan , eprosartan , and losartan .
11561217	0	valsartan	10,19	angiotensin_II	23,37	valsartan	angiotensin II	MESH:C081489	24179(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of valsartan on angiotensin_II - and vasopressin-degrading activities in the kidney of normotensive and hypertensive rats .
14761074	0	valsartan	40,49	angiotensin_II	14,28	valsartan	angiotensin II	MESH:C081489	183	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|antagonist antagonist|amod|END_ENTITY	Effect of the angiotensin_II antagonist valsartan on sexual function in hypertensive men .
15991938	0	valsartan	16,25	angiotensin_II	30,44	valsartan	angiotensin II	MESH:C081489	183	Chemical	Gene	antagonist|nmod|START_ENTITY antagonist|nsubj|receptor receptor|compound|END_ENTITY	Pharmacology of valsartan , an angiotensin_II receptor antagonist .
16247790	0	valsartan	52,61	angiotensin_II	19,33	valsartan	angiotensin II	MESH:C081489	183	Chemical	Gene	blocker|appos|START_ENTITY blocker|amod|END_ENTITY	Notable effects of angiotensin_II receptor blocker , valsartan , on acute cardiotoxic changes after standard chemotherapy with cyclophosphamide , doxorubicin , vincristine , and prednisolone .
18633763	0	valsartan	59,68	angiotensin_II	21,35	valsartan	angiotensin II	MESH:C081489	183	Chemical	Gene	blockade|nmod|START_ENTITY blockade|amod|END_ENTITY	Long-term effects of angiotensin_II receptor blockade with valsartan on carotid arterial stiffness and hemodynamic alterations in patients with essential hypertension .
19080339	0	valsartan	10,19	angiotensin_II	41,55	valsartan	angiotensin II	MESH:C081489	24179(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|receptors receptors|amod|END_ENTITY	Effect of valsartan on the expression of angiotensin_II receptors in the lung of chronic antigen exposure rats .
20428262	0	valsartan	44,53	angiotensin_II	12,26	valsartan	angiotensin II	MESH:C081489	183	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|blocker blocker|amod|END_ENTITY	Role of the angiotensin_II receptor blocker valsartan in heart_failure .
20504911	0	valsartan	61,70	angiotensin_II	114,128	valsartan	angiotensin II	MESH:C081489	183	Chemical	Gene	Contribution|nmod|START_ENTITY Contribution|nmod|END_ENTITY	Contribution of bradykinin B2 receptors to the inhibition by valsartan of systemic and renal effects of exogenous angiotensin_II in salt-repleted humans .
8242249	0	valsartan	27,36	angiotensin_II	92,106	valsartan	angiotensin II	MESH:C081489	24179(Tax:10116)	Chemical	Gene	profile|nmod|START_ENTITY profile|dep|antagonist antagonist|nmod|subtype subtype|amod|END_ENTITY	Pharmacological profile of valsartan : a potent , orally active , nonpeptide antagonist of the angiotensin_II AT1-receptor subtype .
9024172	0	valsartan	14,23	angiotensin_II	31,45	valsartan	angiotensin II	MESH:C081489	183	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|response response|amod|END_ENTITY	The effect of valsartan on the angiotensin_II pressor response in healthy normotensive male subjects .
9848776	0	valsartan	41,50	angiotensin_II	15,29	valsartan	angiotensin II	MESH:C081489	183	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|antagonist antagonist|amod|END_ENTITY	Effects of the angiotensin_II antagonist valsartan on blood pressure , proteinuria , and renal hemodynamics in patients with chronic_renal_failure and hypertension .
12515751	0	valsartan	99,108	angiotensin_II_type_1_receptor	59,89	valsartan	angiotensin II type 1 receptor	MESH:C081489	185	Chemical	Gene	blocker|appos|START_ENTITY blocker|amod|END_ENTITY	Fluvastatin enhances the inhibitory effects of a selective angiotensin_II_type_1_receptor blocker , valsartan , on vascular neointimal formation .
14871033	0	valsartan	53,62	angiotensin_II_type_1_receptor	13,43	valsartan	angiotensin II type 1 receptor	MESH:C081489	185	Chemical	Gene	blocker|appos|START_ENTITY blocker|amod|END_ENTITY	Effect of an angiotensin_II_type_1_receptor blocker , valsartan , on neurohumoral factors in patients with hypertension : comparison with a long-acting calcium channel antagonist , amlodipine .
17322151	0	valsartan	57,66	angiotensin_II_type_1_receptor	15,45	valsartan	angiotensin II type 1 receptor	MESH:C081489	185	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|antagonist antagonist|amod|END_ENTITY	Effects of the angiotensin_II_type_1_receptor antagonist valsartan on the expression of superoxide_dismutase in hypertensive patients .
22429340	0	valsartan	173,182	angiotensin_II_type_1_receptor	23,53	valsartan	angiotensin II type 1 receptor	MESH:C081489	185	Chemical	Gene	combination|nmod|START_ENTITY focus|nmod|combination Efficacy|dep|focus Efficacy|nmod|therapy therapy|amod|END_ENTITY	Efficacy and safety of angiotensin_II_type_1_receptor blocker/calcium channel blocker combination therapy for hypertension : focus on a single-pill fixed-dose combination of valsartan and amlodipine .
9205773	0	valsartan	27,36	angiotensin_II_type_1_receptor	52,82	valsartan	angiotensin II type 1 receptor	MESH:C081489	81638(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Pharmacological profile of valsartan , a non-peptide angiotensin_II_type_1_receptor antagonist .
9205774	0	valsartan	27,36	angiotensin_II_type_1_receptor	52,82	valsartan	angiotensin II type 1 receptor	MESH:C081489	81638(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Pharmacological profile of valsartan , a non-peptide angiotensin_II_type_1_receptor antagonist .
9205775	0	valsartan	27,36	angiotensin_II_type_1_receptor	52,82	valsartan	angiotensin II type 1 receptor	MESH:C081489	81638(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Pharmacological profile of valsartan , a non-peptide angiotensin_II_type_1_receptor antagonist .
9205776	0	valsartan	27,36	angiotensin_II_type_1_receptor	52,82	valsartan	angiotensin II type 1 receptor	MESH:C081489	81638(Tax:10116)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Pharmacological profile of valsartan , a non-peptide angiotensin_II_type_1_receptor antagonist .
9205777	0	valsartan	27,36	angiotensin_II_type_1_receptor	52,82	valsartan	angiotensin II type 1 receptor	MESH:C081489	403836(Tax:9615)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Pharmacological profile of valsartan , a non-peptide angiotensin_II_type_1_receptor antagonist .
10217360	0	valsartan	119,128	angiotensin_converting_enzyme	26,55	valsartan	angiotensin converting enzyme	MESH:C081489	100009274(Tax:9986)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Antiatherogenic effect of angiotensin_converting_enzyme inhibitor -LRB- benazepril -RRB- and angiotensin II receptor antagonist -LRB- valsartan -RRB- in the cholesterol-fed rabbits .
23141017	0	valsartan	12,21	angiotensin_converting_enzyme_2	32,63	valsartan	angiotensin converting enzyme 2	MESH:C081489	302668(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effects of valsartan on aortic angiotensin_converting_enzyme_2 expression after aortic_balloon_injury in rats -RSB- .
12417542	0	valsartan	11,20	brain_natriuretic_peptide	36,61	valsartan	brain natriuretic peptide	MESH:C081489	4879	Chemical	Gene	START_ENTITY|acl|circulating circulating|dobj|END_ENTITY	Effects of valsartan on circulating brain_natriuretic_peptide and norepinephrine in symptomatic chronic_heart_failure : the Valsartan Heart Failure Trial -LRB- Val-HeFT -RRB- .
16159967	0	valsartan	23,32	brain_natriuretic_peptide	96,121	valsartan	brain natriuretic peptide	MESH:C081489	4879	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nsubj|effects	Comparative effects of valsartan and enalapril on cardiac sympathetic nerve activity and plasma brain_natriuretic_peptide in patients with congestive_heart_failure .
23288202	0	valsartan	57,66	cardiotrophin-1	22,37	valsartan	cardiotrophin-1	MESH:C081489	29201(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Downregulation of the cardiotrophin-1 gene expression by valsartan and spironolactone in hypertrophied heart rats in vivo and rat cardiomyocyte H9c2 cell line in vitro : a novel mechanism of cardioprotection .
21924077	0	valsartan	11,20	cyclooxygenase-2	24,40	valsartan	cyclooxygenase-2	MESH:C081489	5743	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effect of valsartan on cyclooxygenase-2 expression in cultured human umbilical vein endothelial cells stimulated by ox-LDL -RSB- .
16115171	0	valsartan	10,19	erythropoietin	23,37	valsartan	erythropoietin	MESH:C081489	2056	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Effect of valsartan on erythropoietin and hemoglobin levels in stage III-IV chronic_kidney_disease patients .
16097363	0	valsartan	29,38	leptin	64,70	valsartan	leptin	MESH:C081489	3952	Chemical	Gene	effects|nmod|START_ENTITY Comparison|nmod|effects Comparison|nmod|END_ENTITY	Comparison of the effects of valsartan and felodipine on plasma leptin and insulin sensitivity in hypertensive obese patients .
17073832	0	valsartan	156,165	renin	66,71	valsartan	renin	MESH:C081489	5972	Chemical	Gene	Lack|appos|START_ENTITY Lack|appos|inhibitor inhibitor|compound|END_ENTITY	Lack of pharmacokinetic interactions of aliskiren , a novel direct renin inhibitor for the treatment of hypertension , with the antihypertensives amlodipine , valsartan , hydrochlorothiazide -LRB- HCTZ -RRB- and ramipril in healthy volunteers .
17322151	0	valsartan	57,66	superoxide_dismutase	88,108	valsartan	superoxide dismutase	MESH:C081489	6647	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effects of the angiotensin_II_type_1_receptor antagonist valsartan on the expression of superoxide_dismutase in hypertensive patients .
17996144	0	valsartan	11,20	vWF	67,70	valsartan	vWF	MESH:C081489	100009165(Tax:9986)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of valsartan on neointimal proliferation and expression of vWF after balloon angioplasty in rabbits -RSB- .
23289969	0	valsartan	27,36	vWf	55,58	valsartan	vWf	MESH:C081489	7450	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|levels levels|compound|END_ENTITY	The comparative effects of valsartan and amlodipine on vWf levels and N/L ratio in patients with newly diagnosed hypertension .
16644520	0	valsartan	11,20	vascular_endothelial_growth_factor	56,90	valsartan	vascular endothelial growth factor	MESH:C081489	22339(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of valsartan on stress-induced changes of serum vascular_endothelial_growth_factor and nitric_oxide in mice .
9505992	0	valspodar	29,38	P-glycoprotein	42,56	valspodar	P-glycoprotein	MESH:C070272	5243	Chemical	Gene	START_ENTITY|appos|modulator modulator|amod|END_ENTITY	Optimizing the absorption of valspodar , a P-glycoprotein modulator , Part I : Selecting an oral formulation and exploring its clinical pharmacokinetics/dynamics .
16300728	0	vanadate	41,49	COX-2	13,18	vanadate	COX-2	MESH:D014638	4513	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Induction of COX-2 protein expression by vanadate in A549 human lung_carcinoma cell line through EGF_receptor and p38 MAPK-mediated pathway .
16289562	0	vanadate	45,53	GLUT4	35,40	vanadate	GLUT4	MESH:D014638	25139(Tax:10116)	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|appos|END_ENTITY	Modulation of glucose_transporter -LRB- GLUT4 -RRB- by vanadate and Trigonella in alloxan-diabetic rats .
2157361	0	vanadate	35,43	Glutathione_reductase	0,21	vanadate	Glutathione reductase	MESH:D014638	2936	Chemical	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	Glutathione_reductase functions as vanadate -LRB- V -RRB- reductase .
10862623	1	vanadate	144,152	HSF	137,140	vanadate	HSF	MESH:D014638	3569	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|END_ENTITY	Modulation of HSF by vanadate and wortmannin .
1868959	0	vanadate	71,79	Lipoprotein_lipase	0,18	vanadate	Lipoprotein lipase	MESH:D014638	24539(Tax:10116)	Chemical	Gene	treatment|amod|START_ENTITY effect|nmod|treatment END_ENTITY|dep|effect	Lipoprotein_lipase in experimental diabetic rats : beneficial effect of vanadate treatment .
3001574	0	vanadate	38,46	acetylcholinesterase	14,34	vanadate	acetylcholinesterase	MESH:D014638	83817(Tax:10116)	Chemical	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of acetylcholinesterase by vanadate .
3852694	0	vanadate	15,23	cathepsin_D	41,52	vanadate	cathepsin D	MESH:D014638	1509	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of vanadate and molybdate on cathepsin_D ; relationship to ATP activation of lysosomal proteolysis .
10595652	0	vanadate	21,29	cyclo-oxygenase-2	57,74	vanadate	cyclo-oxygenase-2	MESH:D014638	5743	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Comparative study of vanadate - and phorbol_ester-induced cyclo-oxygenase-2 expression in human endothelial cells .
7756169	0	vanadate	64,72	estradiol_receptor	12,30	vanadate	estradiol receptor	MESH:D014638	2099	Chemical	Gene	activity|nmod|START_ENTITY role|nmod|activity role|nmod|END_ENTITY	The role of estradiol_receptor in the proliferative activity of vanadate on MCF-7 cells .
15362196	0	vanadate	11,19	glucokinase	46,57	vanadate	glucokinase	MESH:D014638	103988(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of vanadate on the activities of mice glucokinase and hexokinase .
3888984	0	vanadate	25,33	glucose-6-phosphate_dehydrogenase	39,72	vanadate	glucose-6-phosphate dehydrogenase	MESH:D014638	2539	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of inorganic vanadate with glucose-6-phosphate_dehydrogenase .
8834772	0	vanadate	24,32	glucose-6-phosphate_dehydrogenase	67,100	vanadate	glucose-6-phosphate dehydrogenase	MESH:D014638	24377(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|nmod|synthase synthase|amod|END_ENTITY	Insulin-like effects of vanadate and selenate on the expression of glucose-6-phosphate_dehydrogenase and fatty_acid synthase in diabetic rats .
16289562	0	vanadate	45,53	glucose_transporter	14,33	vanadate	glucose transporter	MESH:D014638	25139(Tax:10116)	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|END_ENTITY	Modulation of glucose_transporter -LRB- GLUT4 -RRB- by vanadate and Trigonella in alloxan-diabetic rats .
11520307	0	vanadate	10,18	insulin	103,110	vanadate	insulin	MESH:D014638	3630	Chemical	Gene	adipocytes|amod|START_ENTITY Effect|nmod|adipocytes Effect|dep|evidence evidence|nmod|action action|compound|END_ENTITY	Effect of vanadate on glycogen synthesis in dexamethasone-treated 3T3 adipocytes : evidence for a novel insulin sensitizing action .
15097851	0	vanadate	32,40	insulin	70,77	vanadate	insulin	MESH:D014638	3630	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Long-term beneficial effects of vanadate , tungstate , and molybdate on insulin secretion and function of cultured beta cells .
3305500	4	vanadate	608,616	insulin	553,560	vanadate	insulin	MESH:D014638	3630	Chemical	Gene	found|nsubjpass|START_ENTITY found|advcl|monitored monitored|nsubjpass|efflux efflux|nmod|END_ENTITY	When the net efflux of insulin from cells into the medium was then monitored , vanadate was found to slow the efflux of insulin from a t1/2 of 6.2 min -LRB- controls -RRB- to 11 min .
3305500	7	vanadate	1705,1713	insulin	1746,1753	vanadate	insulin	MESH:D014638	3630	Chemical	Gene	presence|nmod|START_ENTITY prevented|nmod|presence prevented|nsubjpass|receptors receptors|compound|END_ENTITY	In related studies Tris was found to inhibit insulin-mediated receptor recycling by only 10 % , whereas in the presence of vanadate -LRB- plus Tris -RRB- almost all incoming insulin receptors were prevented from recycling .
10037256	0	vanadate	55,63	insulin_receptor	120,136	vanadate	insulin receptor	MESH:D014638	24954(Tax:10116)	Chemical	Gene	rats|nmod|START_ENTITY Treatment|nmod|rats prevents|nsubj|Treatment prevents|dobj|over-expression over-expression|nmod|gene gene|compound|END_ENTITY	Treatment of streptozotocin-induced diabetic rats with vanadate and phlorizin prevents the over-expression of the liver insulin_receptor gene .
2647469	0	vanadate	30,38	insulin_receptor	62,78	vanadate	insulin receptor	MESH:D014638	16337(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY correlated|nsubjpass|effect correlated|nmod|activity activity|compound|END_ENTITY	The insulin-mimetic effect of vanadate is not correlated with insulin_receptor tyrosine kinase activity nor phosphorylation in mouse diaphragm in vivo .
6407485	0	vanadate	23,31	insulin_receptor	114,130	vanadate	insulin receptor	MESH:D014638	24954(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|subunit subunit|nmod|END_ENTITY	Insulin-like effect of vanadate on adipocyte glycogen synthase and on phosphorylation of 95,000 dalton subunit of insulin_receptor .
7523848	0	vanadate	35,43	insulin_receptor	52,68	vanadate	insulin receptor	MESH:D014638	24954(Tax:10116)	Chemical	Gene	involve|nmod|START_ENTITY involve|dobj|kinase kinase|compound|END_ENTITY	Does the insulin-mimetic action of vanadate involve insulin_receptor kinase ?
8131857	0	vanadate	57,65	insulin_receptor	84,100	vanadate	insulin receptor	MESH:D014638	3643	Chemical	Gene	kinases|nmod|START_ENTITY protein|amod|kinases Activation|nmod|protein independent|nsubj|Activation independent|nmod|autophosphorylation autophosphorylation|compound|END_ENTITY	Activation of mitogen activated protein -LRB- MAP -RRB- kinases by vanadate is independent of insulin_receptor autophosphorylation .
9829343	0	vanadate	15,23	insulin_receptor	53,69	vanadate	insulin receptor	MESH:D014638	3643	Chemical	Gene	sensitive|amod|START_ENTITY erythrocytes|amod|sensitive Development|nmod|erythrocytes END_ENTITY|nsubj|Development	Development of vanadate sensitive human erythrocytes insulin_receptor tyrosine phosphatase assay .
2161642	0	vanadate	21,29	lipoprotein_lipase	33,51	vanadate	lipoprotein lipase	MESH:D014638	24539(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Increasing effect of vanadate on lipoprotein_lipase activity in isolated rat fat pads .
2735761	0	vanadate	72,80	lipoprotein_lipase	23,41	vanadate	lipoprotein lipase	MESH:D014638	24539(Tax:10116)	Chemical	Gene	pads|nmod|START_ENTITY pads|nsubj|release release|nmod|activity activity|amod|END_ENTITY	Stimulatory release of lipoprotein_lipase activity from rat fat pads by vanadate .
2119816	0	vanadate	60,68	p56lck	42,48	vanadate	p56lck	MESH:D014638	3932	Chemical	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	The retarded electrophoretic migration of p56lck induced by vanadate in lymphoma cells correlates with modified kinase activity .
7896750	0	vanadate	23,31	p72syk	0,6	vanadate	p72syk	MESH:D014638	6850	Chemical	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	p72syk is activated by vanadate plus H2O2 in porcine platelets and phosphorylates GTPase activating protein on tyrosine residue -LRB- s -RRB- .
1382616	0	vanadate	14,22	phenylalanine_hydroxylase	46,71	vanadate	phenylalanine hydroxylase	MESH:D014638	24616(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|nmod|END_ENTITY	The effect of vanadate upon the expression of phenylalanine_hydroxylase in streptozotocin-diabetic rat liver .
8403423	0	vanadate	15,23	phospholipase_A2	82,98	vanadate	phospholipase A2	MESH:D014638	151056	Chemical	Gene	START_ENTITY|nmod|activities activities|nmod|END_ENTITY	The effects of vanadate and epidermal_growth_factor on the specific activities of phospholipase_A2 and phosphatidylinositol-specific phospholipase C in human amnion cells .
6364150	0	vanadate	38,46	renin	19,24	vanadate	renin	MESH:D014638	403838(Tax:9615)	Chemical	Gene	responses|acl|START_ENTITY responses|compound|END_ENTITY	Cardiovascular and renin responses to vanadate in the conscious dog : attenuation after calcium channel blockade .
6569067	0	vanadate	11,19	transferrin	35,46	vanadate	transferrin	MESH:D014638	7018	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of vanadate to human serum transferrin .
6559036	0	vanadate	36,44	vasopressin	14,25	vanadate	vasopressin	MESH:D014638	551	Chemical	Gene	action|nmod|START_ENTITY action|compound|END_ENTITY	Inhibition of vasopressin action by vanadate in the cortical collecting tubule .
20221682	0	vanadium	64,72	CYP1A1	54,60	vanadium	CYP1A1	MESH:D014639	1543	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional and posttranscriptional regulation of CYP1A1 by vanadium in human hepatoma HepG2 cells .
18541696	0	vanadium	77,85	cytochrome_P450_1a1	54,73	vanadium	cytochrome P450 1a1	MESH:D014639	13076(Tax:10090)	Chemical	Gene	enzyme|nmod|START_ENTITY enzyme|dobj|END_ENTITY	Down-regulation of the carcinogen-metabolizing enzyme cytochrome_P450_1a1 by vanadium .
24927405	0	vanadium	41,49	erythropoietin	107,121	vanadium	erythropoietin	MESH:D014639	13856(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|role role|nmod|END_ENTITY	Neurobehavioral and cytotoxic effects of vanadium during oligodendrocyte maturation : a protective role for erythropoietin .
7854499	0	vanadium	135,143	erythropoietin	9,23	vanadium	erythropoietin	MESH:D014639	13856(Tax:10090)	Chemical	Gene	administration|nmod|START_ENTITY lymphoma|nmod|administration activity|nmod|lymphoma END_ENTITY|nmod|activity	Enhanced erythropoietin and suppression of gamma-glutamyl_transpeptidase -LRB- GGT -RRB- activity in murine lymphoma following administration of vanadium .
19033682	0	vanadium	10,18	insulin	22,29	vanadium	insulin	MESH:D014639	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|sensitivity sensitivity|compound|END_ENTITY	Effect of vanadium on insulin sensitivity in patients with impaired_glucose_tolerance .
20927665	0	vanadium	10,18	leptin	88,94	vanadium	leptin	MESH:D014639	25608(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|role role|nmod|END_ENTITY	Effect of vanadium on renal Na + , K + - ATPase activity in diabetic rats : a possible role of leptin .
18322232	0	vanadium_pentoxide	57,75	STAT-1	0,6	vanadium pentoxide	STAT-1	MESH:C066075	6772	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	STAT-1 signaling in human lung fibroblasts is induced by vanadium_pentoxide through an IFN-beta autocrine loop .
11294500	0	vanadyl_sulfate	59,74	neuropeptide_Y	25,39	vanadyl sulfate	neuropeptide Y	MESH:C034028	24604(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Decrease of hypothalamic neuropeptide_Y gene expression by vanadyl_sulfate in streptozotocin-induced diabetic rats .
6524101	0	vancomycin	28,38	CSF	59,62	vancomycin	CSF	MESH:D014640	1437	Chemical	Gene	START_ENTITY|nmod|treatment treatment|nmod|ventriculitis ventriculitis|compound|END_ENTITY	The use of intraventricular vancomycin in the treatment of CSF shunt-associated ventriculitis .
7434044	2	vancomycin	400,410	CSF	386,389	vancomycin	CSF	MESH:D014640	1437	Chemical	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	During three episodes in two patients with proved or suspected central_nervous_system_infection , CSF levels of vancomycin ranged from < 0.5 to 1.54 microgram/ml ; in only two of six CSF specimens did the antibiotic level exceed its in vitro inhibitory concentration for the infecting organism .
9109096	0	vancomycin	18,28	VanA	13,17	vancomycin	VanA	MESH:D014640	13917379	Chemical	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	Induction of VanA vancomycin resistance genes in Enterococcus_faecalis : use of a promoter fusion to evaluate glycopeptide and nonglycopeptide induction signals .
11691577	0	vancomycin	38,48	vanB	33,37	vancomycin	vanB	MESH:D014640	7072424(Tax:1351)	Chemical	Gene	resistance|compound|START_ENTITY resistance|amod|END_ENTITY	Lactoferrin-induced reduction of vanB vancomycin resistance in enterococci .
8051238	0	vancomycin	82,92	vanB	71,75	vancomycin	vanB	MESH:D014640	6779647(Tax:1352)	Chemical	Gene	resistance|compound|START_ENTITY resistance|compound|END_ENTITY	Outbreak of multidrug-resistant Enterococcus_faecium with transferable vanB class vancomycin resistance .
27036030	0	vandetanib	62,72	SEC23A	13,19	vandetanib	SEC23A	MESH:C452423	10484	Chemical	Gene	efficacy|nmod|START_ENTITY END_ENTITY|nmod|efficacy	MicroRNA-375 / SEC23A as biomarkers of the in vitro efficacy of vandetanib .
19528456	0	vandetanib	64,74	VEGF	21,25	vandetanib	VEGF	MESH:C452423	7422	Chemical	Gene	efficacy|nmod|START_ENTITY END_ENTITY|nmod|efficacy	Impact of tumor cell VEGF expression on the in vivo efficacy of vandetanib -LRB- ZACTIMA ; ZD6474 -RRB- .
17393165	0	vandetanib	69,79	VEGFR	28,33	vandetanib	VEGFR	MESH:C452423	3791	Chemical	Gene	kinase|dobj|START_ENTITY kinase|nsubj|scheduling scheduling|nmod|END_ENTITY	Dose scheduling of the dual VEGFR and EGFR tyrosine kinase inhibitor vandetanib -LRB- ZD6474 , Zactima -RRB- in combination with radiotherapy in EGFR-positive and EGFR-null human head_and_neck_tumor xenografts .
17671152	0	vandetanib	71,81	Vascular_endothelial_growth_factor	0,34	vandetanib	Vascular endothelial growth factor	MESH:C452423	7422	Chemical	Gene	inhibitors|dobj|START_ENTITY inhibitors|nsubj|kinase kinase|compound|END_ENTITY	Vascular_endothelial_growth_factor receptor tyrosine kinase inhibitors vandetanib -LRB- ZD6474 -RRB- and AZD2171 in lung_cancer .
19447868	0	vandetanib	107,117	vascular_endothelial_growth_factor	9,43	vandetanib	vascular endothelial growth factor	MESH:C452423	7422	Chemical	Gene	concentration|nmod|START_ENTITY concentration|compound|END_ENTITY	Baseline vascular_endothelial_growth_factor concentration as a potential predictive marker of benefit from vandetanib in non-small_cell_lung_cancer .
17385724	0	vanilloid	62,71	TRPV1	84,89	vanilloid	TRPV1	null	7442	Chemical	Gene	receptor-1|amod|START_ENTITY receptor-1|appos|END_ENTITY	Insulin and insulin-like growth factor type-I up-regulate the vanilloid receptor-1 -LRB- TRPV1 -RRB- in stably TRPV1-expressing SH-SY5Y neuroblastoma cells .
18259730	1	vanilloid	197,206	TRPV1	217,222	vanilloid	TRPV1	null	83810(Tax:10116)	Chemical	Gene	receptor|amod|START_ENTITY receptor|dep|END_ENTITY	The transient receptor potential V1 channel -LRB- vanilloid receptor , TRPV1 -RRB- represents a promising therapeutic target for inflammatory pain and other conditions involving C-fiber sensory afferent neurons .
19705551	0	vanilloid	12,21	TRPV1	32,37	vanilloid	TRPV1	null	193034(Tax:10090)	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Deletion of vanilloid receptor -LRB- TRPV1 -RRB- in mice alters behavioral effects of ethanol .
11333266	0	vanilloid	21,30	VR1	43,46	vanilloid	VR1	null	7442	Chemical	Gene	START_ENTITY|dobj|receptor receptor|appos|END_ENTITY	Anandamide activates vanilloid receptor 1 -LRB- VR1 -RRB- at acidic pH in dorsal root ganglia neurons and cells ectopically expressing VR1 .
9708861	0	vanilloid	63,72	VR1	95,98	vanilloid	VR1	null	83810(Tax:10116)	Chemical	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Capsaicin sensitivity is associated with the expression of the vanilloid _ -LRB- capsaicin -RRB- _ receptor -LRB- VR1 -RRB- mRNA in adult rat sensory ganglia .
12475462	0	vardenafil	14,24	phosphodiesterase-5	56,75	vardenafil	phosphodiesterase-5	MESH:C426063	8654	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|inhibitor inhibitor|amod|END_ENTITY	The effect of vardenafil , a potent and highly selective phosphodiesterase-5 inhibitor for the treatment of erectile_dysfunction , on the cardiovascular response to exercise in patients with coronary_artery_disease .
15213306	0	vardenafil	47,57	phosphodiesterase-5	65,84	vardenafil	phosphodiesterase-5	MESH:C426063	8654	Chemical	Gene	START_ENTITY|nmod|site site|amod|END_ENTITY	Binding of tritiated sildenafil , tadalafil , or vardenafil to the phosphodiesterase-5 catalytic site displays potency , specificity , heterogeneity , and cGMP stimulation .
16926278	0	vardenafil	78,88	phosphodiesterase-5	27,46	vardenafil	phosphodiesterase-5	MESH:C426063	8654	Chemical	Gene	potency|amod|START_ENTITY provides|nmod|potency provides|nsubj|segment segment|nmod|domain domain|amod|END_ENTITY	A 46-amino_acid segment in phosphodiesterase-5 GAF-B domain provides for high vardenafil potency over sildenafil and tadalafil and is involved in phosphodiesterase-5 dimerization .
17471999	0	vardenafil	52,62	phosphodiesterase-5	77,96	vardenafil	phosphodiesterase-5	MESH:C426063	8654	Chemical	Gene	administration|nmod|START_ENTITY efficacy|nmod|administration efficacy|dep|inhibitor inhibitor|nmod|END_ENTITY	-LSB- Therapeutic efficacy of a course administration of vardenafil -- inhibitor of phosphodiesterase-5 -- in erectile_dysfunction -RSB- .
17959709	0	vardenafil	131,141	phosphodiesterase-5	34,53	vardenafil	phosphodiesterase-5	MESH:C426063	8654	Chemical	Gene	effects|nmod|START_ENTITY basis|nmod|effects provide|dobj|basis provide|nsubj|variations variations|nmod|END_ENTITY	Conformational variations of both phosphodiesterase-5 and inhibitors provide the structural basis for the physiological effects of vardenafil and sildenafil .
11669467	0	vardenafil	86,96	phosphodiesterase_type_5	117,141	vardenafil	phosphodiesterase type 5	MESH:C426063	8654	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Inhibition of cyclic_GMP hydrolysis in human corpus cavernosum smooth muscle cells by vardenafil , a novel , selective phosphodiesterase_type_5 inhibitor .
19125990	0	vardenafil	94,104	phosphodiesterase_type_5	46,70	vardenafil	phosphodiesterase type 5	MESH:C426063	8654	Chemical	Gene	therapy|nmod|START_ENTITY therapy|amod|END_ENTITY	Improvement in duration of erection following phosphodiesterase_type_5 inhibitor therapy with vardenafil in men with erectile_dysfunction : the ENDURANCE study .
23071714	0	varespladib	18,29	secretory_phospholipase_A2	33,59	varespladib	secretory phospholipase A2	MESH:C117948	5320	Chemical	Gene	effect|nmod|START_ENTITY Ex|dobj|effect Ex|nmod|activity activity|amod|END_ENTITY	Ex vivo effect of varespladib on secretory_phospholipase_A2 alveolar activity in infants with ARDS .
23986519	0	vasopressin	59,70	AQP2	30,34	vasopressin	AQP2	MESH:D014667	25386(Tax:10116)	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Excretion of urinary exosomal AQP2 in rats is regulated by vasopressin and urinary pH. Urinary exosomes are small vesicles secreted into urine from all renal epithelial cell types and known to contain proteins that are involved in renal secretion and reabsorption .
12151754	0	vasopressin	26,37	Aquaporin-2	0,11	vasopressin	Aquaporin-2	MESH:D014667	25386(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Aquaporin-2 regulation by vasopressin in the rat inner ear .
2950195	0	vasopressin	82,93	Atrial_natriuretic_factor	0,25	vasopressin	Atrial natriuretic factor	MESH:D014667	24602(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY inhibits|dobj|release inhibits|nsubj|END_ENTITY	Atrial_natriuretic_factor inhibits the stimulated in-vivo and in-vitro release of vasopressin and oxytocin in the rat .
18486126	0	vasopressin	15,26	ERK	30,33	vasopressin	ERK	MESH:D014667	5594	Chemical	Gene	START_ENTITY|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Stimulation by vasopressin of ERK phosphorylation and vector-driven water flux in astrocytes is transactivation-dependent .
8953469	0	vasopressin	39,50	IL-1_beta	26,35	vasopressin	IL-1 beta	MESH:D014667	24494(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY END_ENTITY|nmod|release	Changing effect of i.c.v. IL-1_beta on vasopressin release in anaesthetized , female rats at different stages of lactation : role of prostaglandins and noradrenaline .
2620703	0	vasopressin	45,56	Interleukin-1_beta	0,18	vasopressin	Interleukin-1 beta	MESH:D014667	24494(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Interleukin-1_beta stimulates the release of vasopressin from rat neurohypophysis .
7620610	0	vasopressin	69,80	Interleukin-1_beta	0,18	vasopressin	Interleukin-1 beta	MESH:D014667	24494(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Interleukin-1_beta stimulates both central and peripheral release of vasopressin and oxytocin in the rat .
23393317	0	vasopressin	29,40	SPAK	0,4	vasopressin	SPAK	MESH:D014667	53416(Tax:10090)	Chemical	Gene	effects|compound|START_ENTITY mediates|dobj|effects mediates|nsubj|END_ENTITY	SPAK differentially mediates vasopressin effects on sodium cotransporters .
2434765	0	vasopressin	58,69	V1a	54,57	vasopressin	V1a	MESH:D014667	25107(Tax:10116)	Chemical	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	WRK1 cells : a model system for studying properties of V1a vasopressin receptors .
8129742	0	vasopressin	120,131	V1a	37,40	vasopressin	V1a	MESH:D014667	54140(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|antagonist antagonist|amod|END_ENTITY	Effect of a new , potent , non-peptide V1a vasopressin antagonist , SR_49059 , on the binding and the mitogenic activity of vasopressin on Swiss_3T3 cells .
2860491	0	vasopressin	41,52	VIII	14,18	vasopressin	VIII	MESH:D014667	1351	Chemical	Gene	analogue|compound|START_ENTITY END_ENTITY|nmod|analogue	Absent factor VIII response to synthetic vasopressin analogue -LRB- DDAVP -RRB- in nephrogenic_diabetes_insipidus .
11166690	0	vasopressin	76,87	angiotensin_II	29,43	vasopressin	angiotensin II	MESH:D014667	24179(Tax:10116)	Chemical	Gene	secretion|compound|START_ENTITY regulation|nmod|secretion interactions|nmod|regulation interactions|nmod|END_ENTITY	Central interactions between angiotensin_II and PGD -LRB- 2 -RRB- in the regulation of vasopressin and oxytocin secretion in dehydrated rats .
14988085	0	vasopressin	64,75	angiotensin_II	97,111	vasopressin	angiotensin II	MESH:D014667	24179(Tax:10116)	Chemical	Gene	levels|compound|START_ENTITY levels|acl|stimulated stimulated|nmod|END_ENTITY	Acute increases_in_arterial_blood_pressure do not reduce plasma vasopressin levels stimulated by angiotensin_II or hyperosmolality in rats .
168023	0	vasopressin	48,59	angiotensin_II	15,29	vasopressin	angiotensin II	MESH:D014667	24179(Tax:10116)	Chemical	Gene	release|nmod|START_ENTITY END_ENTITY|nmod|release	Stimulation by angiotensin_II of the release of vasopressin from incubated rat neurohypophyses -- possible involvement of cyclic_AMP .
2797385	0	vasopressin	10,21	angiotensin_II	51,65	vasopressin	angiotensin II	MESH:D014667	24179(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY Effect|nmod|release Effect|nmod|END_ENTITY	Effect on vasopressin release of microinjection of angiotensin_II into the paraventricular nucleus of conscious rats .
510629	0	vasopressin	118,129	angiotensin_II	37,51	vasopressin	angiotensin II	MESH:D014667	24179(Tax:10116)	Chemical	Gene	secretion|compound|START_ENTITY ventricle|nmod|secretion injected|nmod|ventricle -LSB-|dep|injected -LSB-|dobj|comparison comparison|nmod|effects effects|nmod|END_ENTITY	-LSB- A comparison between the effects of angiotensin_II and angiotensin_III injected into the third cerebral ventricle on vasopressin secretion in conscious rats -LRB- author 's transl -RRB- -RSB- .
7386111	0	vasopressin	76,87	angiotensin_II	107,121	vasopressin	angiotensin II	MESH:D014667	24179(Tax:10116)	Chemical	Gene	level|compound|START_ENTITY Sar1-Ala8-angiotensin_II|nmod|level injection|nmod|Sar1-Ala8-angiotensin_II Effects|nmod|injection increased|nsubj|Effects increased|nmod|END_ENTITY	Effects of intraventricular injection of Sar1-Ala8-angiotensin_II on plasma vasopressin level increased by angiotensin_II and by water_deprivation in conscious rats .
7413018	0	vasopressin	69,80	angiotensin_II	42,56	vasopressin	angiotensin II	MESH:D014667	24179(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY infusion|nmod|release infusion|nsubj|Effect Effect|nmod|END_ENTITY	Effect of chronic intracerebroventricular angiotensin_II infusion on vasopressin release in rats .
7869608	0	vasopressin	112,123	angiotensin_II	19,33	vasopressin	angiotensin II	MESH:D014667	24179(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY produce|nmod|release produce|nsubj|Microinjections Microinjections|nmod|END_ENTITY	Microinjections of angiotensin_II into the supraoptic and paraventricular nuclei produce potent antidiureses by vasopressin release mediated through adrenergic and angiotensin receptors .
10973964	0	vasopressin	41,52	aquaporin-2	14,25	vasopressin	aquaporin-2	MESH:D014667	359	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|trafficking trafficking|amod|END_ENTITY	Regulation of aquaporin-2 trafficking by vasopressin in the renal collecting duct .
25977473	0	vasopressin	64,75	aquaporin-2	41,52	vasopressin	aquaporin-2	MESH:D014667	359	Chemical	Gene	START_ENTITY|nsubj|feedback feedback|nmod|CaSR CaSR|acl|signaling signaling|nmod|sensitizes sensitizes|amod|END_ENTITY	Negative feedback from CaSR signaling to aquaporin-2 sensitizes vasopressin to extracellular Ca2 .
8818115	0	vasopressin	8,19	aquaporin-2	55,66	vasopressin	aquaporin-2	MESH:D014667	25386(Tax:10116)	Chemical	Gene	receptor|compound|START_ENTITY Role|nmod|receptor Role|nmod|END_ENTITY	Role of vasopressin V2 receptor in acute regulation of aquaporin-2 .
9895089	0	vasopressin	25,36	aquaporin-2	48,59	vasopressin	aquaporin-2	MESH:D014667	359	Chemical	Gene	START_ENTITY|nmod|excretion excretion|amod|END_ENTITY	The effects of intrinsic vasopressin on urinary aquaporin-2 excretion and urine osmolality during surgery under general anesthesia .
19180911	0	vasopressin	11,22	aquaporin_7	26,37	vasopressin	aquaporin 7	MESH:D014667	29171(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	-LSB- Effect of vasopressin on aquaporin_7 expression in rat inner ear -RSB- .
2160040	0	vasopressin	9,20	c-fos	47,52	vasopressin	c-fos	MESH:D014667	14281(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Arginine vasopressin induces the expression of c-fos in the mouse septum and hippocampus .
8487952	0	vasopressin	136,147	c-fos	14,19	vasopressin	c-fos	MESH:D014667	314322(Tax:10116)	Chemical	Gene	infusions|nmod|START_ENTITY Expression|nmod|infusions Expression|nmod|END_ENTITY	Expression of c-fos in restricted areas of the basal forebrain and brainstem following single or combined intraventricular infusions of vasopressin and corticotropin-releasing_factor .
7683555	0	vasopressin	3,14	corticotropin-releasing_factor	44,74	vasopressin	corticotropin-releasing factor	MESH:D014667	81648(Tax:10116)	Chemical	Gene	released|nsubjpass|START_ENTITY released|nmod|END_ENTITY	Is vasopressin preferentially released from corticotropin-releasing_factor and vasopressin containing nerve terminals in the median eminence of adrenalectomized rats ?
6332965	0	vasopressin	67,78	corticotropin_releasing_factor	24,54	vasopressin	corticotropin releasing factor	MESH:D014667	81648(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	In vivo potentiation of corticotropin_releasing_factor activity by vasopressin analogues .
8350273	0	vasopressin	26,37	endothelin-3	10,22	vasopressin	endothelin-3	MESH:D014667	366270(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY END_ENTITY|nmod|release	Effect of endothelin-3 on vasopressin release in vitro and water excretion in vivo in Long-Evans rats .
11956139	0	vasopressin	37,48	ghrelin	8,15	vasopressin	ghrelin	MESH:D014667	59301(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Role of ghrelin in the regulation of vasopressin release in conscious rats .
7707232	0	vasopressin	42,53	interleukin-1_beta	8,26	vasopressin	interleukin-1 beta	MESH:D014667	24494(Tax:10116)	Chemical	Gene	release|compound|START_ENTITY stimulation|nmod|release stimulation|amod|END_ENTITY	Central interleukin-1_beta stimulation of vasopressin release into the rat brain : activation of an antipyretic pathway .
3510566	0	vasopressin	59,70	renin	88,93	vasopressin	renin	MESH:D014667	403838(Tax:9615)	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of the vasoconstrictor and antidiuretic activities of vasopressin in inhibition of renin secretion in conscious dogs .
7000504	0	vasopressin	31,42	renin	67,72	vasopressin	renin	MESH:D014667	403838(Tax:9615)	Chemical	Gene	concentration|compound|START_ENTITY concentration|nmod|activity activity|compound|END_ENTITY	Effects of increases in plasma vasopressin concentration on plasma renin activity , blood pressure , heart rate , and plasma corticosteroid concentration in conscious dogs .
17536010	0	vasotocin	30,39	CRH	77,80	vasotocin	CRH	MESH:D014668	1392	Chemical	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Heterooligomerization between vasotocin and corticotropin-releasing_hormone -LRB- CRH -RRB- receptors augments CRH-stimulated 3 ' ,5 ' - cyclic_adenosine_monophosphate production .
9094265	0	vasotocin	69,78	NHE3	47,51	vasotocin	NHE3	MESH:D014668	100009430(Tax:9986)	Chemical	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	Regulation of the transfected Na + / H + - exchanger NHE3 in MDCK cells by vasotocin .
27016389	0	vasotocin	18,27	NPY	134,137	vasotocin	NPY	MESH:D014668	4852	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Central effect of vasotocin 4 receptor -LRB- VT4R/V1aR -RRB- antagonists on the stress response and food intake in chicks given neuropeptide_Y -LRB- NPY -RRB- .
27016389	0	vasotocin	18,27	VT4R/V1aR	40,49	vasotocin	VT4R/V1aR	MESH:D014668	552	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Central effect of vasotocin 4 receptor -LRB- VT4R/V1aR -RRB- antagonists on the stress response and food intake in chicks given neuropeptide_Y -LRB- NPY -RRB- .
19248046	0	vatalanib	107,116	vascular_endothelial_growth_factor_receptor	37,80	vatalanib	vascular endothelial growth factor receptor	MESH:C404768	3791	Chemical	Gene	START_ENTITY|amod|tyrosine tyrosine|amod|END_ENTITY	Phase I pharmacokinetic study of the vascular_endothelial_growth_factor_receptor tyrosine kinase inhibitor vatalanib -LRB- PTK787 -RRB- plus imatinib and hydroxyurea for malignant_glioma .
22730329	0	vemurafenib	117,128	B-RAF	138,143	vemurafenib	B-RAF	MESH:C551177	673	Chemical	Gene	START_ENTITY|nmod|melanoma melanoma|compound|END_ENTITY	Reactivation of mitogen-activated protein kinase -LRB- MAPK -RRB- pathway by FGF receptor 3 -LRB- FGFR3 -RRB- / Ras mediates resistance to vemurafenib in human B-RAF V600E mutant melanoma .
21609436	2	vemurafenib	434,445	BRAF	549,553	vemurafenib	LKB1	MESH:C551177	6794	Chemical	Gene	combination|nmod|START_ENTITY tested|nsubjpass|combination tested|nmod|END_ENTITY	MATERIALS AND METHODS : The combination of the BRAF inhibitor vemurafenib -LRB- formerly PLX4032 -RRB- and metformin were tested against a panel of human melanoma cell lines with defined BRAF and NRAS mutations for effects on viability , cell cycle and apoptosis .
21639808	0	vemurafenib	23,34	BRAF	52,56	vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	survival|nmod|START_ENTITY survival|nmod|mutation mutation|compound|END_ENTITY	Improved survival with vemurafenib in melanoma with BRAF V600E mutation .
22180495	0	vemurafenib	37,48	BRAF	22,26	vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	inhibitor|xcomp|START_ENTITY inhibitor|nsubj|activity activity|nmod|END_ENTITY	Antitumor activity of BRAF inhibitor vemurafenib in preclinical models of BRAF-mutant colorectal_cancer .
22306669	0	vemurafenib	158,169	BRAF	80,84	vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	test|nmod|START_ENTITY used|nmod|test used|nsubj|performance performance|nmod|assay assay|nmod|mutations mutations|nmod|gene gene|compound|END_ENTITY	Analytical performance of a real-time PCR-based assay for V600 mutations in the BRAF gene , used as the companion diagnostic test for the novel BRAF inhibitor vemurafenib in metastatic_melanoma .
22356324	0	vemurafenib	60,71	BRAF	12,16	vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	treated|nmod|START_ENTITY melanoma|acl|treated advanced|dobj|melanoma advanced|nsubj|Survival Survival|nmod|V600-mutant V600-mutant|compound|END_ENTITY	Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib .
22431713	0	vemurafenib	40,51	BRAF	74,78	vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	START_ENTITY|nmod|pathway pathway|compound|END_ENTITY	Cutaneous toxic effects associated with vemurafenib and inhibition of the BRAF pathway .
22448344	0	vemurafenib	132,143	BRAF	78,82	vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	RAF|nmod|START_ENTITY insensitivity|xcomp|RAF insensitivity|nmod|colorectal_cancers colorectal_cancers|amod|END_ENTITY	EGFR-mediated re-activation of MAPK signaling contributes to insensitivity of BRAF mutant colorectal_cancers to RAF inhibition with vemurafenib .
22454535	0	vemurafenib	131,142	BRAF	115,119	vemurafenib	BRAF	MESH:C551177	109880(Tax:10090)	Chemical	Gene	Impact|dep|START_ENTITY Impact|nmod|distribution distribution|nmod|inhibitor inhibitor|compound|END_ENTITY	Impact of P-glycoprotein -LRB- ABCB1 -RRB- and breast_cancer_resistance_protein -LRB- ABCG2 -RRB- on the brain distribution of a novel BRAF inhibitor : vemurafenib -LRB- PLX4032 -RRB- .
23153455	2	vemurafenib	480,491	BRAF	447,451	vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	inhibitor|appos|START_ENTITY signaling|dobj|inhibitor BRAF|acl|signaling BRAF|nmod|END_ENTITY	The discovery of constitutive activation of the BRAF kinase caused by activating BRAF -LRB- V600E -RRB- kinase mutation in most melanoma patients led to the discovery of the first potent BRAF -LRB- V600E -RRB- signaling inhibitor , vemurafenib .
23258922	0	vemurafenib	21,32	BRAF	142,146	vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	efficacy|nmod|START_ENTITY efficacy|acl|harboring harboring|dobj|mutation mutation|compound|END_ENTITY	Dramatic efficacy of vemurafenib in both multisystemic and refractory Erdheim-Chester_disease and Langerhans_cell_histiocytosis harboring the BRAF V600E mutation .
23326492	0	vemurafenib	162,173	BRAF	51,55	vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	test|nmod|START_ENTITY study|nmod|test Comparison|dep|study Comparison|nmod|methods methods|nmod|detection detection|nmod|mutations mutations|compound|END_ENTITY	Comparison of testing methods for the detection of BRAF V600E mutations in malignant melanoma : pre-approval validation study of the companion diagnostic test for vemurafenib .
23360189	0	vemurafenib	36,47	BRAF	0,4	vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	treatment|amod|START_ENTITY algorithm|nmod|treatment algorithm|compound|END_ENTITY	BRAF mutation testing algorithm for vemurafenib treatment in melanoma : recommendations from an expert panel .
23481513	0	vemurafenib	40,51	BRAF	106,110	vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	START_ENTITY|nmod|treatment treatment|nmod|patients patients|nmod|unresectable unresectable|compound|END_ENTITY	The European Medicines Agency review of vemurafenib -LRB- Zelboraf -RRB- for the treatment of adult patients with BRAF V600 mutation-positive unresectable or metastatic melanoma : summary of the scientific assessment of the Committee for Medicinal Products for Human Use .
23658559	6	vemurafenib	913,924	BRAF	861,865	vemurafenib	NRAS	MESH:C551177	4893	Chemical	Gene	sensitive|xcomp|START_ENTITY sensitive|nsubj|lines lines|nmod|mutations mutations|compound|END_ENTITY	Cell lines with activating BRAF mutations were significantly more sensitive to vemurafenib than lines with NRAS mutations or lines lacking either mutation -LRB- p < 0.001 -RRB- .
24023633	0	vemurafenib	60,71	BRAF	75,79	vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	kinase|nmod|START_ENTITY kinase|nmod|END_ENTITY	Differential inhibition of ex-vivo tumor kinase activity by vemurafenib in BRAF -LRB- V600E -RRB- and BRAF wild-type metastatic malignant_melanoma .
24035431	0	vemurafenib	59,70	BRAF	25,29	vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	refractory|xcomp|START_ENTITY refractory|nsubj|Lung_adenocarcinoma Lung_adenocarcinoma|nmod|mutation mutation|compound|END_ENTITY	Lung_adenocarcinoma with BRAF G469L mutation refractory to vemurafenib .
24108467	0	vemurafenib	91,102	BRAF	34,38	vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	associated|xcomp|START_ENTITY associated|nsubj|Identification Identification|nmod|mutation mutation|compound|END_ENTITY	Identification of a novel complex BRAF mutation associated with major clinical response to vemurafenib in a patient with metastatic_melanoma .
24178368	0	vemurafenib	81,92	BRAF	110,114	vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|metastatic_melanoma metastatic_melanoma|compound|END_ENTITY	A phase I , randomized , open-label study of the multiple-dose pharmacokinetics of vemurafenib in patients with BRAF V600E mutation-positive metastatic_melanoma .
24531394	0	vemurafenib	128,139	BRAF	35,39	vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	BRAF|dobj|START_ENTITY BRAF|nsubj|incidence incidence|nmod|melanoma melanoma|compound|END_ENTITY	High incidence of naevi-associated BRAF wild-type melanoma and dysplastic naevi under treatment with the class I BRAF inhibitor vemurafenib .
24559688	0	vemurafenib	126,137	BRAF	94,98	vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	NRAS|nmod|START_ENTITY NRAS|nsubj|role role|nmod|pathway pathway|nmod|sensitivity sensitivity|nmod|/ /|compound|END_ENTITY	Prominent role of cyclic_adenosine_monophosphate signalling pathway in the sensitivity of -LRB- WT -RRB- BRAF / -LRB- WT -RRB- NRAS melanoma cells to vemurafenib .
24641301	0	vemurafenib	79,90	BRAF	104,108	vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Histopathologic characteristics of therapy-associated cutaneous neoplasms with vemurafenib , a selective BRAF kinase inhibitor , used in the treatment of melanoma .
24712861	0	vemurafenib	11,22	BRAF	107,111	vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	use|nmod|START_ENTITY use|acl|containing containing|dobj|mutation mutation|compound|END_ENTITY	The use of vemurafenib in Australian patients with unresectable or metastatic_melanoma containing the V600 BRAF gene mutation .
24735766	0	vemurafenib	62,73	BRAF	38,42	vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	PLX4032|appos|START_ENTITY PLX4032|compound|END_ENTITY	Differential effects of the oncogenic BRAF inhibitor PLX4032 -LRB- vemurafenib -RRB- and its progenitor PLX4720 on ABCB1 function .
24879157	0	vemurafenib	110,121	BRAF	68,72	vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	sensitize|nmod|START_ENTITY sensitize|dobj|cells cells|compound|END_ENTITY	Development of potent autophagy inhibitors that sensitize oncogenic BRAF V600E mutant melanoma_tumor cells to vemurafenib .
24888229	0	vemurafenib	97,108	BRAF	0,4	vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	responding|nmod|START_ENTITY brain|acl|responding V600E-mutated|nmod|brain V600E-mutated|nsubj|END_ENTITY	BRAF V600E-mutated lung adenocarcinoma with metastases to the brain responding to treatment with vemurafenib .
25036880	0	vemurafenib	72,83	BRAF	19,23	vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|Ocular_toxicity Ocular_toxicity|nmod|patients patients|compound|END_ENTITY	Ocular_toxicity in BRAF mutant cutaneous_melanoma patients treated with vemurafenib .
25063807	0	vemurafenib	100,111	BRAF	132,136	vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	resistance|amod|START_ENTITY acquired|dobj|resistance acquired|nmod|cells cells|compound|END_ENTITY	Mitogen-activated protein kinase -LRB- MAPK -RRB- hyperactivation and enhanced NRAS expression drive acquired vemurafenib resistance in V600E BRAF melanoma cells .
25128147	0	vemurafenib	18,29	BRAF	103,107	vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	cell|amod|START_ENTITY response|nmod|cell histiocytosis|nsubj|response histiocytosis|xcomp|harboring harboring|dobj|mutation mutation|compound|END_ENTITY	Major response to vemurafenib in patient with severe cutaneous Langerhans cell histiocytosis harboring BRAF V600E mutation .
25128147	0	vemurafenib	18,29	BRAF	103,107	vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	cell|amod|START_ENTITY response|nmod|cell histiocytosis|nsubj|response histiocytosis|xcomp|harboring harboring|dobj|mutation mutation|compound|END_ENTITY	Major response to vemurafenib in patient with severe cutaneous Langerhans cell histiocytosis harboring BRAF V600E mutation .
25364391	0	vemurafenib	25,36	BRAF	40,44	vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	START_ENTITY|nmod|melanoma melanoma|compound|END_ENTITY	Intermittent dosing with vemurafenib in BRAF V600E-mutant melanoma : review of a case series .
25466451	0	vemurafenib	44,55	BRAF	83,87	vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	START_ENTITY|nmod|patient patient|nmod|V600E-mutant V600E-mutant|compound|END_ENTITY	Response to dabrafenib after progression on vemurafenib in a patient with advanced BRAF V600E-mutant bronchial adenocarcinoma .
25515853	0	vemurafenib	190,201	BRAF	147,151	vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|mutation mutation|nmod|patients patients|compound|END_ENTITY	Detailed imaging and genetic analysis reveal a secondary BRAF -LRB- L -RRB- -LRB- 505H -RRB- resistance mutation and extensive intrapatient heterogeneity in metastatic BRAF mutant melanoma patients treated with vemurafenib .
25515853	0	vemurafenib	190,201	BRAF	57,61	vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	treated|nmod|START_ENTITY END_ENTITY|acl:relcl|treated	Detailed imaging and genetic analysis reveal a secondary BRAF -LRB- L -RRB- -LRB- 505H -RRB- resistance mutation and extensive intrapatient heterogeneity in metastatic BRAF mutant melanoma patients treated with vemurafenib .
25779180	0	vemurafenib	61,72	BRAF	130,134	vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	START_ENTITY|nmod|cobimetinib cobimetinib|nmod|END_ENTITY	coBRIM : a phase 3 , double-blind , placebo-controlled study of vemurafenib versus vemurafenib + cobimetinib in previously untreated BRAF -LRB- V600 -RRB- mutation-positive patients with unresectable locally advanced or metastatic_melanoma -LRB- NCT01689519 -RRB- .
25779180	0	vemurafenib	80,91	BRAF	130,134	vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	cobimetinib|amod|START_ENTITY cobimetinib|nmod|END_ENTITY	coBRIM : a phase 3 , double-blind , placebo-controlled study of vemurafenib versus vemurafenib + cobimetinib in previously untreated BRAF -LRB- V600 -RRB- mutation-positive patients with unresectable locally advanced or metastatic_melanoma -LRB- NCT01689519 -RRB- .
25779194	0	vemurafenib	23,34	BRAF	38,42	vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	Safety|nmod|START_ENTITY Safety|nmod|melanomas melanomas|compound|END_ENTITY	Safety and efficacy of vemurafenib in BRAF V600E mutation-positive metastatic melanomas .
25795880	3	vemurafenib	959,970	BRAF	980,984	vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	We show that the MEK inhibitor trametinib is more synergistic in combination with the BRAF inhibitor dabrafenib than with vemurafenib , another BRAF inhibitor .
25980594	0	vemurafenib	64,75	BRAF	21,25	vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	treated|nmod|START_ENTITY patients|acl|treated outcome|dep|patients outcome|nmod|END_ENTITY	Long-term outcome in BRAF -LRB- V600E -RRB- melanoma patients treated with vemurafenib : Patterns of disease progression and clinical management of limited progression .
25980594	0	vemurafenib	64,75	BRAF	21,25	vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	treated|nmod|START_ENTITY patients|acl|treated outcome|dep|patients outcome|nmod|END_ENTITY	Long-term outcome in BRAF -LRB- V600E -RRB- melanoma patients treated with vemurafenib : Patterns of disease progression and clinical management of limited progression .
25991583	0	vemurafenib	103,114	BRAF	35,39	vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	receiving|dobj|START_ENTITY metastases|xcomp|receiving metastases|nsubj|patterns patterns|nmod|patients patients|compound|END_ENTITY	Treatment patterns and outcomes in BRAF V600E-mutant melanoma patients with brain metastases receiving vemurafenib in the real-world setting .
26115708	0	vemurafenib	69,80	BRAF	84,88	vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Pronounced response of papillary_craniopharyngioma to treatment with vemurafenib , a BRAF inhibitor .
26433819	0	vemurafenib	65,76	BRAF	177,181	vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	melanoma|amod|START_ENTITY melanoma|compound|END_ENTITY	Comparison of dabrafenib and trametinib combination therapy with vemurafenib monotherapy on health-related quality of life in patients with unresectable or metastatic cutaneous BRAF Val600-mutation-positive melanoma -LRB- COMBI-v -RRB- : results of a phase 3 , open-label , randomised trial .
26490654	0	vemurafenib	22,33	BRAF	78,82	vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	response|nmod|START_ENTITY serous|nsubj|response serous|nmod|mutation mutation|compound|END_ENTITY	Sustained response to vemurafenib in a low grade serous ovarian_cancer with a BRAF V600E mutation .
26790143	0	vemurafenib	80,91	BRAF	63,67	vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	melanoma|nmod|START_ENTITY melanoma|compound|END_ENTITY	p53 Reactivation by PRIMA-1 -LRB- Met -RRB- -LRB- APR-246 -RRB- sensitises -LRB- V600E/K -RRB- BRAF melanoma to vemurafenib .
26941398	0	vemurafenib	53,64	BRAF	0,4	vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|END_ENTITY	BRAF inhibition in hairy_cell_leukemia with low dose vemurafenib .
26983408	0	vemurafenib	10,21	BRAF	39,43	vemurafenib	BRAF	MESH:C551177	673	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	Safety of vemurafenib in patients with BRAF -LRB- V600 -RRB- mutated metastatic melanoma : the Spanish experience .
27025703	5	vemurafenib	654,665	BRAF	709,713	vemurafenib	CRAF	MESH:C551177	5894	Chemical	Gene	identified|nsubjpass|START_ENTITY identified|nmod|activator activator|nmod|homo homo|compound|END_ENTITY	Using optoRAF , vemurafenib was identified as paradoxical activator of BRAF and CRAF homo - and heterodimers .
25379693	0	venlafaxine	24,35	BDNF	84,88	venlafaxine	BDNF	MESH:C047426	24225(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Dose-related effects of venlafaxine on pCREB and brain-derived_neurotrophic_factor -LRB- BDNF -RRB- in the hippocampus of the rat by chronic unpredictable stress .
20466523	0	venlafaxine	54,65	P-glycoprotein	102,116	venlafaxine	P-glycoprotein	MESH:C047426	67078(Tax:10090)	Chemical	Gene	enantiomers|nmod|START_ENTITY penetration|nmod|enantiomers penetration|acl|lacking lacking|dobj|END_ENTITY	Blood-brain barrier penetration of the enantiomers of venlafaxine and its metabolites in mice lacking P-glycoprotein .
21191569	0	venlafaxine	94,105	P-glycoprotein	113,127	venlafaxine	P-glycoprotein	MESH:C047426	67078(Tax:10090)	Chemical	Gene	treatment|nmod|START_ENTITY Effects|nmod|treatment Effects|nmod|model model|amod|END_ENTITY	Effects on enantiomeric drug disposition and open-field behavior after chronic treatment with venlafaxine in the P-glycoprotein knockout mice model .
23090625	0	venlafaxine	26,37	SERT	0,4	venlafaxine	SERT	MESH:C047426	102133349	Chemical	Gene	occupancy|nmod|START_ENTITY occupancy|nsubj|END_ENTITY	SERT and NET occupancy by venlafaxine and milnacipran in nonhuman primates : a PET study .
20081236	0	venlafaxine	22,33	brain-derived_neurotrophic_factor	109,142	venlafaxine	brain-derived neurotrophic factor	MESH:C047426	24225(Tax:10116)	Chemical	Gene	Influences|nmod|START_ENTITY Influences|nmod|concentrations concentrations|nmod|END_ENTITY	Influences of chronic venlafaxine , olanzapine and nicotine on the hippocampal and cortical concentrations of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- .
21984156	0	venlafaxine	11,22	brain-derived_neurotrophic_factor	61,94	venlafaxine	brain-derived neurotrophic factor	MESH:C047426	24225(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY function|nsubj|Effect function|dobj|expression expression|amod|END_ENTITY	-LSB- Effect of venlafaxine on cognitive function and hippocampal brain-derived_neurotrophic_factor expression in rats with post-stroke_depression -RSB- .
22961097	0	venlafaxine	98,109	brain-derived_neurotrophic_factor	35,68	venlafaxine	brain-derived neurotrophic factor	MESH:C047426	627	Chemical	Gene	treatment|nmod|START_ENTITY END_ENTITY|nmod|treatment	Changes of serum concentrations of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- during treatment with venlafaxine and mirtazapine : role of medication and response to treatment .
15584914	0	venlafaxine	128,139	synaptophysin	16,29	venlafaxine	synaptophysin	MESH:C047426	24804(Tax:10116)	Chemical	Gene	stress|nmod|START_ENTITY stress|nsubj|response response|nmod|END_ENTITY	The response of synaptophysin and microtubule-associated_protein_1 to restraint stress in rat hippocampus and its modulation by venlafaxine .
20651837	0	venlafaxine	19,30	synaptophysin	34,47	venlafaxine	synaptophysin	MESH:C047426	20977(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Chronic effects of venlafaxine on synaptophysin and neuronal_cell_adhesion_molecule in the hippocampus of cerebral ischemic mice .
3489244	0	verapamil	15,24	CRF	99,102	verapamil	CRF	MESH:D014700	81648(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	The effects of verapamil on the locomotor-activating properties of corticotropin_releasing_factor -LRB- CRF -RRB- in the rat .
26265240	0	verapamil	75,84	CYP3A	140,145	verapamil	CYP3A	MESH:D014700	170509(Tax:10116)	Chemical	Gene	Impact|nmod|START_ENTITY Impact|nmod|END_ENTITY	Impact of inhalational exposure to ethanol fuel on the pharmacokinetics of verapamil , ibuprofen and fluoxetine as in vivo probe drugs for CYP3A , CYP2C and CYP2D in rats .
15689501	0	verapamil	64,73	CYP3A4	43,49	verapamil	CYP3A4	MESH:D014700	1576	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Differential mechanism-based inhibition of CYP3A4 and CYP3A5 by verapamil .
15905061	0	verapamil	36,45	CYP3A4	17,23	verapamil	CYP3A4	MESH:D014700	1576	Chemical	Gene	study|nmod|START_ENTITY study|nmod|activity activity|compound|END_ENTITY	Kinetic study of CYP3A4 activity on verapamil by capillary electrophoresis .
884389	0	verapamil	19,28	Cd2	14,17	verapamil	Cd2	MESH:D014700	607448(Tax:9615)	Chemical	Gene	+|amod|START_ENTITY +|compound|END_ENTITY	Inhibition by Cd2 + verapamil and papaverine of Ca2 + - induced contractions in isolated cerebral and peripheral arteries of the dog .
19331130	0	verapamil	10,19	EGFR	41,45	verapamil	EGFR	MESH:D014700	1956	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	Effect of verapamil on the expression of EGFR and NM23 in A549 human lung_cancer cells .
2341719	0	verapamil	60,69	IL-6	36,40	verapamil	IL-6	MESH:D014700	3569	Chemical	Gene	modulation|nmod|START_ENTITY modulation|nmod|expression expression|compound|END_ENTITY	Transcriptional modulation of human IL-6 gene expression by verapamil .
9042229	0	verapamil	11,20	MDR-1	34,39	verapamil	MDR-1	MESH:D014700	5243	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effects of verapamil and S9788 on MDR-1 mRNA expression studied by in situ hybridization .
20563580	0	verapamil	25,34	MDR1	81,85	verapamil	MDR1	MESH:D014700	5243	Chemical	Gene	modulators|xcomp|START_ENTITY modulators|nmod|levels levels|nmod|END_ENTITY	Effect of MDR modulators verapamil and promethazine on gene expression levels of MDR1 and MRP1 in doxorubicin-resistant MCF-7 cells .
26171231	0	verapamil	141,150	MDR1	202,206	verapamil	MDR1	MESH:D014700	5243	Chemical	Gene	permeability|nmod|START_ENTITY affect|dobj|permeability affect|nmod|END_ENTITY	The putative P-gp inhibitor telmisartan does not affect the transcellular permeability and cellular uptake of the calcium channel antagonist verapamil in the P-glycoprotein expressing cell line MDCK II MDR1 .
8487584	0	verapamil	10,19	MDR1	98,102	verapamil	MDR1	MESH:D014700	5243	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|cells cells|nmod|levels levels|nmod|expression expression|compound|END_ENTITY	Effect of verapamil on daunorubicin accumulation in human leukemic cells with different levels of MDR1 gene expression .
9275712	0	verapamil	27,36	MDR1	79,83	verapamil	MDR1	MESH:D014700	5243	Chemical	Gene	effect|nmod|START_ENTITY transfected|nsubj|effect transfected|nmod|gene gene|compound|END_ENTITY	Chemosensitizing effect of verapamil on Swiss-3T3 cells transfected with human MDR1 gene .
10773005	0	verapamil	45,54	P-glycoprotein	87,101	verapamil	P-glycoprotein	MESH:D014700	5243	Chemical	Gene	metabolites|nmod|START_ENTITY Characterization|nmod|metabolites Characterization|nmod|END_ENTITY	Characterization of the major metabolites of verapamil as substrates and inhibitors of P-glycoprotein .
10783826	0	verapamil	18,27	P-glycoprotein	57,71	verapamil	P-glycoprotein	MESH:D014700	5243	Chemical	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Affinities at the verapamil binding site of MDR1-encoded P-glycoprotein : drugs and analogs , stereoisomers and metabolites .
11279063	0	verapamil	119,128	P-glycoprotein	65,79	verapamil	P-glycoprotein	MESH:D014700	5243	Chemical	Gene	MTS-verapamil|compound|START_ENTITY analog|nmod|MTS-verapamil using|dobj|analog END_ENTITY|xcomp|using	Defining the drug-binding site in the human multidrug resistance P-glycoprotein using a methanethiosulfonate analog of verapamil , MTS-verapamil .
11804391	0	verapamil	100,109	P-glycoprotein	14,28	verapamil	P-glycoprotein	MESH:D014700	287115(Tax:10116)	Chemical	Gene	impact|nmod|START_ENTITY impact|nmod|efflux efflux|amod|END_ENTITY	The impact of P-glycoprotein efflux on enterocyte residence time and enterocyte-based metabolism of verapamil .
15328394	0	verapamil	7,16	P-glycoprotein	32,46	verapamil	P-glycoprotein	MESH:D014700	5243	Chemical	Gene	Use|nmod|START_ENTITY Use|nmod|inhibitor inhibitor|amod|END_ENTITY	Use of verapamil as a potential P-glycoprotein inhibitor in a patient with refractory_epilepsy .
16003291	0	verapamil	10,19	P-glycoprotein	112,126	verapamil	P-glycoprotein	MESH:D014700	5243	Chemical	Gene	Effect|nmod|START_ENTITY Effect|dep|evidence evidence|nmod|involvement involvement|nmod|END_ENTITY	Effect of verapamil on pharmacokinetics and pharmacodynamics of risperidone : in vivo evidence of involvement of P-glycoprotein in risperidone disposition .
1670642	0	verapamil	122,131	P-glycoprotein	0,14	verapamil	P-glycoprotein	MESH:D014700	5243	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	P-glycoprotein expression in malignant_lymphoma and reversal of clinical drug resistance with chemotherapy plus high-dose verapamil .
1684906	0	verapamil	147,156	P-glycoprotein	171,185	verapamil	P-glycoprotein	MESH:D014700	5243	Chemical	Gene	START_ENTITY|nmod|absence absence|nmod|overexpression overexpression|amod|END_ENTITY	Doxorubicin selected multidrug-resistant small_cell_lung_cancer cell lines characterised by elevated cytoplasmic Ca2 + and resistance modulation by verapamil in absence of P-glycoprotein overexpression .
17920233	0	verapamil	55,64	P-glycoprotein	120,134	verapamil	P-glycoprotein	MESH:D014700	67078(Tax:10090)	Chemical	Gene	cells|nmod|START_ENTITY treatment|nmod|cells induces|nsubj|treatment induces|dobj|down-regulation down-regulation|nmod|expression expression|amod|END_ENTITY	Combined treatment of P-gp-positive L1210/VCR cells by verapamil and all-trans_retinoic_acid induces down-regulation of P-glycoprotein expression and transport activity .
19135530	0	verapamil	36,45	P-glycoprotein	10,24	verapamil	P-glycoprotein	MESH:D014700	287115(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Effect of P-glycoprotein inhibitor , verapamil , on oral bioavailability and pharmacokinetics of irinotecan in rats .
1967551	0	verapamil	55,64	P-glycoprotein	79,93	verapamil	P-glycoprotein	MESH:D014700	5243	Chemical	Gene	analogue|nmod|START_ENTITY Binding|nmod|analogue Binding|nmod|END_ENTITY	Binding of an optically pure photoaffinity analogue of verapamil , LU-49888 , to P-glycoprotein from multidrug-resistant human leukemic cell lines .
19898809	0	verapamil	49,58	P-glycoprotein	125,139	verapamil	P-glycoprotein	MESH:D014700	287115(Tax:10116)	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY lovastatin|nmod|pharmacokinetics Effects|nmod|lovastatin Effects|dep|role role|nmod|inhibition inhibition|amod|END_ENTITY	Effects of lovastatin on the pharmacokinetics of verapamil and its active metabolite , norverapamil in rats : possible role of P-glycoprotein inhibition by lovastatin .
20069466	0	verapamil	137,146	P-glycoprotein	24,38	verapamil	P-glycoprotein	MESH:D014700	5243	Chemical	Gene	study|nmod|START_ENTITY effect|dep|study effect|nmod|function function|amod|END_ENTITY	No inhibitory effect on P-glycoprotein function at blood-brain barrier by clinical dose of clarithromycin : a human PET study with -LSB- C -RSB- verapamil .
21640186	0	verapamil	96,105	P-glycoprotein	76,90	verapamil	P-glycoprotein	MESH:D014700	287115(Tax:10116)	Chemical	Gene	modulating|nmod|START_ENTITY modulating|dobj|END_ENTITY	Study on in situ and in vivo absorption kinetics of phenytoin by modulating P-glycoprotein with verapamil in rats .
22504657	0	verapamil	106,115	P-glycoprotein	85,99	verapamil	P-glycoprotein	MESH:D014700	67078(Tax:10090)	Chemical	Gene	using|dobj|START_ENTITY mice|xcomp|using mice|nmod|inhibition inhibition|nmod|END_ENTITY	Suppression of intestinal polyp development in Apc -LRB- Min / + -RRB- mice through inhibition of P-glycoprotein using verapamil .
22545967	0	verapamil	21,30	P-glycoprotein	105,119	verapamil	P-glycoprotein	MESH:D014700	287115(Tax:10116)	Chemical	Gene	Interactions|nmod|START_ENTITY Interactions|dep|role role|nmod|inhibition inhibition|nmod|END_ENTITY	Interactions between verapamil and digoxin in Langendorff-perfused rat hearts : the role of inhibition of P-glycoprotein in the heart .
24044638	0	verapamil	101,110	P-glycoprotein	10,24	verapamil	P-glycoprotein	MESH:D014700	287115(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of P-glycoprotein on the rat intestinal permeability and metabolism of the BDDCS class 1 drug verapamil .
25030439	0	verapamil	78,87	P-glycoprotein	91,105	verapamil	P-glycoprotein	MESH:D014700	67078(Tax:10090)	Chemical	Gene	all-trans_retinoic_acid|nmod|START_ENTITY all-trans_retinoic_acid|nmod|expression expression|amod|END_ENTITY	Effect of 9-cis retinoic_acid and all-trans_retinoic_acid in combination with verapamil on P-glycoprotein expression in L1210 cells .
2564428	0	verapamil	135,144	P-glycoprotein	77,91	verapamil	P-glycoprotein	MESH:D014700	5243	Chemical	Gene	addition|nmod|START_ENTITY circumvention|nmod|addition circumvention|amod|END_ENTITY	Drug-resistance in multiple myeloma and non-Hodgkin 's _ lymphoma : detection of P-glycoprotein and potential circumvention by addition of verapamil to chemotherapy .
2569930	0	verapamil	138,147	P-glycoprotein	88,102	verapamil	P-glycoprotein	MESH:D014700	5243	Chemical	Gene	mechanism|nmod|START_ENTITY mechanism|nmod|END_ENTITY	Reversal mechanism of multidrug resistance by verapamil : direct binding of verapamil to P-glycoprotein on specific sites and transport of verapamil outward across the plasma membrane of K562/ADM cells .
2569930	0	verapamil	46,55	P-glycoprotein	88,102	verapamil	P-glycoprotein	MESH:D014700	5243	Chemical	Gene	multidrug|nmod|START_ENTITY mechanism|acl|multidrug mechanism|nmod|END_ENTITY	Reversal mechanism of multidrug resistance by verapamil : direct binding of verapamil to P-glycoprotein on specific sites and transport of verapamil outward across the plasma membrane of K562/ADM cells .
2569930	0	verapamil	75,84	P-glycoprotein	88,102	verapamil	P-glycoprotein	MESH:D014700	5243	Chemical	Gene	direct|nmod|START_ENTITY verapamil|dep|direct multidrug|nmod|verapamil mechanism|acl|multidrug mechanism|nmod|END_ENTITY	Reversal mechanism of multidrug resistance by verapamil : direct binding of verapamil to P-glycoprotein on specific sites and transport of verapamil outward across the plasma membrane of K562/ADM cells .
26171231	0	verapamil	141,150	P-glycoprotein	158,172	verapamil	P-glycoprotein	MESH:D014700	5243	Chemical	Gene	permeability|nmod|START_ENTITY affect|dobj|permeability affect|nmod|MDR1 MDR1|amod|END_ENTITY	The putative P-gp inhibitor telmisartan does not affect the transcellular permeability and cellular uptake of the calcium channel antagonist verapamil in the P-glycoprotein expressing cell line MDCK II MDR1 .
8694845	0	verapamil	96,105	P-glycoprotein	9,23	verapamil	P-glycoprotein	MESH:D014700	5243	Chemical	Gene	analogue|amod|START_ENTITY photolabeling|nmod|analogue living|advcl|photolabeling functionality|advcl|living functionality|nsubj|Study Study|nmod|END_ENTITY	Study of P-glycoprotein functionality in living resistant K562 cells after photolabeling with a verapamil analogue .
8713080	0	verapamil	24,33	P-glycoprotein	37,51	verapamil	P-glycoprotein	MESH:D014700	5243	Chemical	Gene	START_ENTITY|nmod|ATPase ATPase|compound|END_ENTITY	Effects of steroids and verapamil on P-glycoprotein ATPase activity : progesterone , desoxycorticosterone , corticosterone and verapamil are mutually non-exclusive modulators .
21128075	5	verapamil	802,811	P-gp	787,791	verapamil	MDR1	MESH:D014700	5243	Chemical	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	The involvement of MDR1 in amrubicinol resistance was evaluated by treatment with P-gp inhibitor verapamil and small interfering RNA -LRB- siRNA -RRB- against MDR1 .
1754730	0	verapamil	10,19	VP16	59,63	verapamil	VP16	MESH:D014700	3054	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of verapamil on the uptake and efflux of etoposide -LRB- VP16 -RRB- in both sensitive and resistant cancer cells .
3818041	0	verapamil	45,54	angiotensin_II	78,92	verapamil	angiotensin II	MESH:D014700	24179(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|response response|nmod|END_ENTITY	The effect of acute and chronic treatment of verapamil on pressor response to angiotensin_II in rats .
11996326	0	verapamil	88,97	atrial_natriuretic_peptide	7,33	verapamil	atrial natriuretic peptide	MESH:D014700	4878	Chemical	Gene	treatment|nmod|START_ENTITY END_ENTITY|nmod|treatment	Plasma atrial_natriuretic_peptide levels in essential hypertension after treatment with verapamil .
2148150	0	verapamil	40,49	atrial_natriuretic_peptide	60,86	verapamil	atrial natriuretic peptide	MESH:D014700	4878	Chemical	Gene	treatment|nmod|START_ENTITY influence|nmod|treatment END_ENTITY|nsubj|influence	The influence of chronic treatment with verapamil on plasma atrial_natriuretic_peptide levels in young and elderly hypertensive patients .
1543868	1	verapamil	109,118	calcium	122,129	verapamil	gastrin	MESH:D014700	25320(Tax:10116)	Chemical	Gene	START_ENTITY|appos|blocker blocker|compound|END_ENTITY	The present study examined the effect of verapamil , a calcium channel blocker , on gastric_acid secretion and circulating gastrin levels in rats after ethanol challenge .
3489244	0	verapamil	15,24	corticotropin_releasing_factor	67,97	verapamil	corticotropin releasing factor	MESH:D014700	81648(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|properties properties|nmod|END_ENTITY	The effects of verapamil on the locomotor-activating properties of corticotropin_releasing_factor -LRB- CRF -RRB- in the rat .
10640297	0	verapamil	33,42	endothelial_nitric-oxide_synthase	55,88	verapamil	endothelial nitric-oxide synthase	MESH:D014700	4846	Chemical	Gene	START_ENTITY|dobj|expression expression|amod|END_ENTITY	Nifedipine and diltiazem but not verapamil up-regulate endothelial_nitric-oxide_synthase expression .
10378988	0	verapamil	10,19	endothelin-1	36,48	verapamil	endothelin-1	MESH:D014700	24323(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|responses responses|nmod|END_ENTITY	Effect of verapamil on responses to endothelin-1 in aortic rings from streptozotocin-induced diabetic rats .
8423561	0	verapamil	77,86	endothelin-1	14,26	verapamil	endothelin-1	MESH:D014700	24323(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of endothelin-1 on muscle microcirculation and its attenuation by verapamil .
9112571	0	verapamil	103,112	endothelin-1	16,28	verapamil	endothelin-1	MESH:D014700	403424(Tax:9615)	Chemical	Gene	reversal|nmod|START_ENTITY Contribution|dep|reversal Contribution|acl|END_ENTITY	Contribution of endothelin-1 to renal vasoconstriction in unilateral_ureteral_obstruction : reversal by verapamil .
6774993	2	verapamil	56,65	gonadotropin-releasing_hormone	76,106	verapamil	gonadotropin-releasing hormone	MESH:D014700	2796	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|release release|amod|END_ENTITY	Effects of verapamil on basal , gonadotropin-releasing_hormone - and thyrotropin-releasing hormone-induced pituitary hormone release in normal subjects .
7036659	0	verapamil	5,14	insulin	41,48	verapamil	insulin	MESH:D014700	3630	Chemical	Gene	influence|nsubj|START_ENTITY influence|dobj|release release|compound|END_ENTITY	Does verapamil influence glucose-induced insulin release in man ?
7838133	0	verapamil	70,79	mdr1	46,50	verapamil	mdr1	MESH:D014700	5243	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Evidence for transcriptional control of human mdr1 gene expression by verapamil in multidrug-resistant leukemic cells .
3572310	0	verapamil	10,19	parathyroid_hormone	30,49	verapamil	parathyroid hormone	MESH:D014700	24694(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of verapamil on plasma parathyroid_hormone .
7889637	0	verapamil	20,29	parathyroid_hormone	48,67	verapamil	parathyroid hormone	MESH:D014700	5741	Chemical	Gene	Nifedipine|dep|START_ENTITY elevates|nsubj|Nifedipine elevates|dobj|levels levels|amod|END_ENTITY	Nifedipine , but not verapamil , acutely elevates parathyroid_hormone levels in premenopausal women .
2184050	0	verapamil	42,51	renin	55,60	verapamil	renin	MESH:D014700	24715(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	-LSB- The effect of fenigidin -LRB- nifedipine -RRB- and verapamil on renin activity , the levels of ionized calcium and aldosterone in the blood plasma and on the hemodynamic indices of rats with spontaneous hypertension -RSB- .
2184671	0	verapamil	76,85	renin	14,19	verapamil	renin	MESH:D014700	403838(Tax:9615)	Chemical	Gene	administration|amod|START_ENTITY Regulation|nmod|administration Regulation|nmod|release release|compound|END_ENTITY	Regulation of renin release and renal hemodynamics during acute and chronic verapamil administration .
3286065	0	verapamil	33,42	renin	186,191	verapamil	renin	MESH:D014700	24715(Tax:10116)	Chemical	Gene	blocking|dobj|START_ENTITY calcium|acl|blocking Effect|nmod|calcium ventricular|nsubj|Effect ventricular|nmod|activity activity|compound|END_ENTITY	Effect of calcium blocking agent verapamil on blood pressure , ventricular contractility , parathyroid_hormone , calcium and phosphorus in plasma , catecholamines , corticosterone and plasma renin activity in spontaneously hypertensive rats .
6088131	0	verapamil	82,91	renin	33,38	verapamil	renin	MESH:D014700	100358545(Tax:9986)	Chemical	Gene	effects|nmod|START_ENTITY Secretion|dep|effects Secretion|nmod|END_ENTITY	Secretion of active and inactive renin by rabbit kidney cortex slices : effects of verapamil , flunarizine and A23187 .
6353937	0	verapamil	11,20	renin	24,29	verapamil	renin	MESH:D014700	403838(Tax:9615)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of verapamil on renin and aldosterone in the dog and rat .
23592936	0	verapamil	95,104	resistin	120,128	verapamil	resistin	MESH:D014700	56729	Chemical	Gene	START_ENTITY|acl|circulating circulating|dobj|levels levels|compound|END_ENTITY	Beneficial effect of combination therapy using an angiotensin-converting enzyme inhibitor plus verapamil on circulating resistin levels in hypertensive patients with type 2 diabetes .
9075850	0	verapamil	72,81	vascular_cell_adhesion_molecule-1	24,57	verapamil	vascular cell adhesion molecule-1	MESH:D014700	7412	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|expression expression|amod|END_ENTITY	Selective inhibition of vascular_cell_adhesion_molecule-1 expression by verapamil in human vascular endothelial cells .
11274745	0	veratridine	58,69	CA3	77,80	veratridine	CA3	MESH:D014701	54232(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|neurons neurons|compound|END_ENTITY	Long-term enhancement of synaptic transmission induced by veratridine in rat CA3 hippocampal neurons .
6437894	0	veratridine	10,21	acetylcholinesterase	25,45	veratridine	acetylcholinesterase	MESH:D014701	83817(Tax:10116)	Chemical	Gene	Action|nmod|START_ENTITY Action|nmod|END_ENTITY	Action of veratridine on acetylcholinesterase in cultures of rat muscle cells .
7002570	0	veratrine	45,54	gonadotropin-releasing_hormone	11,41	veratrine	gonadotropin-releasing hormone	MESH:D014702	2796	Chemical	Gene	Release|nmod|START_ENTITY Release|nmod|END_ENTITY	Release of gonadotropin-releasing_hormone by veratrine in a hypothalamic-pituitary_coincubation .
25119735	0	verrucarin_A	40,52	IL-8	14,18	verrucarin A	IL-8	MESH:C005348	3576	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Regulation of IL-8 promoter activity by verrucarin_A in human monocytic THP-1 cells .
20831599	0	vesamicol	33,42	vesicular_acetylcholine_transporter	60,95	vesamicol	vesicular acetylcholine transporter	MESH:C006189	60422(Tax:10116)	Chemical	Gene	sites|amod|START_ENTITY sites|nmod|END_ENTITY	Search for the acetylcholine and vesamicol binding sites in vesicular_acetylcholine_transporter : the region around the lumenal end of the transport channel .
10408967	0	vesnarinone	14,25	TNF_alpha	29,38	vesnarinone	TNF alpha	MESH:C041667	7124	Chemical	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	The effect of vesnarinone on TNF_alpha production in human peripheral blood mononuclear cells and microglia : a preclinical study for the treatment of multiple_sclerosis .
8579603	0	vicinal_dithiols	15,31	fMLP	62,66	vicinal dithiols	fMLP	null	2357	Chemical	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Involvement of vicinal_dithiols in differential regulation of fMLP and phorbol_ester-activated phospholipase_D in stimulated human neutrophils .
17988017	0	videchol	61,69	glucose-6-phosphate_dehydrogenase	74,107	videchol	glucose-6-phosphate dehydrogenase	null	24377(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	-LSB- Adaptogenic effect of the vitamin_D3 containing supplement `` videchol '' on glucose-6-phosphate_dehydrogenase activity in erythrone of irradiated rats -RSB- .
10331702	0	vigabatrin	12,22	ACTH	0,4	vigabatrin	ACTH	MESH:D020888	5443	Chemical	Gene	therapy|compound|START_ENTITY END_ENTITY|nmod|therapy	ACTH versus vigabatrin therapy in infantile_spasms : a retrospective study .
10448817	0	vigabatrin	40,50	GABA-transaminase	105,122	vigabatrin	GABA-transaminase	MESH:D020888	81632(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY course|nmod|effects related|dep|course related|xcomp|platelet platelet|dobj|inhibition inhibition|amod|END_ENTITY	Time course of the GABAergic effects of vigabatrin : is the time course of brain GABA related to platelet GABA-transaminase inhibition ?
18412635	0	vigabatrin	56,66	GABA-transaminase	27,44	vigabatrin	GABA-transaminase	MESH:D020888	268860(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Treatment of epilepsy : the GABA-transaminase inhibitor , vigabatrin , induces neuronal plasticity in the mouse retina .
2399411	0	vigabatrin	30,40	GABA-transaminase	44,61	vigabatrin	GABA-transaminase	MESH:D020888	81632(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Chronic_toxicity studies with vigabatrin , a GABA-transaminase inhibitor .
2757907	0	vigabatrin	14,24	GABA-transaminase	47,64	vigabatrin	GABA-transaminase	MESH:D020888	81632(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activities activities|compound|END_ENTITY	The effect of vigabatrin on brain and platelet GABA-transaminase activities .
8788866	0	vigabatrin	42,52	GABA-transaminase	14,31	vigabatrin	GABA-transaminase	MESH:D020888	81632(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|inhibitor inhibitor|amod|END_ENTITY	Effect of the GABA-transaminase inhibitor vigabatrin on exploratory behaviour in socially isolated rats .
9554704	0	vigabatrin	81,91	GABA-transaminase	47,64	vigabatrin	GABA-transaminase	MESH:D020888	18	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Measuring human brain GABA in vivo : effects of GABA-transaminase inhibition with vigabatrin .
15558944	0	vigabatrin	61,71	GABA_aminotransferase	110,131	vigabatrin	GABA aminotransferase	MESH:D020888	18	Chemical	Gene	Synthesis|nmod|START_ENTITY Synthesis|nmod|END_ENTITY	Synthesis of cyclopropane isosteres of the antiepilepsy drug vigabatrin and evaluation of their inhibition of GABA_aminotransferase .
1915185	0	vigabatrin	101,111	GABA_transaminase	40,57	vigabatrin	GABA transaminase	MESH:D020888	81632(Tax:10116)	Chemical	Gene	doses|nmod|START_ENTITY inhibition|nmod|doses inhibition|nsubj|Relationship Relationship|nmod|END_ENTITY	Relationship between platelet and brain GABA_transaminase inhibition by single and multiple doses of vigabatrin in rats .
22336593	0	vigabatrin	11,21	GABA_transaminase	39,56	vigabatrin	GABA transaminase	MESH:D020888	268860(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Effects of vigabatrin , an irreversible GABA_transaminase inhibitor , on ethanol reinforcement and ethanol discriminative stimuli in mice .
16194568	0	vigabatrin	24,34	neuropeptide_Y	57,71	vigabatrin	neuropeptide Y	MESH:D020888	4852	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|system system|amod|END_ENTITY	Differential effects of vigabatrin and zonisamide on the neuropeptide_Y system in the hippocampus of seizure prone gerbil .
24928338	0	vilanterol	14,24	beta2	46,51	vilanterol	beta2	MESH:C550468	10242	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Comparison of vilanterol , a novel long-acting beta2 agonist , with placebo and a salmeterol reference arm in asthma uncontrolled by inhaled corticosteroids .
15740724	0	vilazodone	100,110	5-HT1A	38,44	vilazodone	5-HT1A	MESH:C494040	24473(Tax:10116)	Chemical	Gene	reuptake|advmod|START_ENTITY reuptake|nsubj|evaluation evaluation|nmod|agonist/serotonin agonist/serotonin|amod|END_ENTITY	Neurochemical evaluation of the novel 5-HT1A receptor partial agonist/serotonin reuptake inhibitor , vilazodone .
20730070	0	vildagliptin	44,56	DPP-4	27,32	vildagliptin	DPP-4	MESH:C502012	1803	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Weight neutrality with the DPP-4 inhibitor , vildagliptin : mechanistic basis and clinical experience .
21755761	0	vildagliptin	59,71	DPP-4	42,47	vildagliptin	DPP-4	MESH:C502012	1803	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|inhibitor inhibitor|appos|END_ENTITY	Emerging role of dipeptidyl_peptidase-IV -LRB- DPP-4 -RRB- inhibitor vildagliptin in the management of type 2 diabetes .
21955567	0	vildagliptin	46,58	DPP-4	30,35	vildagliptin	DPP-4	MESH:C502012	25253(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|effects effects|nmod|inhibitor inhibitor|compound|END_ENTITY	Early and late effects of the DPP-4 inhibitor vildagliptin in a rat model of post-myocardial_infarction_heart_failure .
23650450	0	vildagliptin	101,113	DPP-4	74,79	vildagliptin	DPP-4	MESH:C502012	1803	Chemical	Gene	focus|nmod|START_ENTITY patients|dep|focus patients|nmod|renal_impairment renal_impairment|acl|using using|dobj|inhibitors inhibitors|compound|END_ENTITY	Managing diabetic patients with moderate or severe renal_impairment using DPP-4 inhibitors : focus on vildagliptin .
23848558	0	vildagliptin	39,51	DPP-4	55,60	vildagliptin	DPP-4	MESH:C502012	1803	Chemical	Gene	influences|nmod|START_ENTITY influences|appos|inhibitor inhibitor|compound|END_ENTITY	Cognitive and functional influences of vildagliptin , a DPP-4 inhibitor , added to ongoing metformin therapy in elderly with type 2 diabetes .
24640595	0	vildagliptin	52,64	DPP-4	68,73	vildagliptin	DPP-4	MESH:C502012	1803	Chemical	Gene	determination|nmod|START_ENTITY electrophoresis|nmod|determination electrophoresis|appos|inhibitor inhibitor|compound|END_ENTITY	Capillary zone electrophoresis for determination of vildagliptin -LRB- a DPP-4 inhibitor -RRB- in pharmaceutical formulation and comparative study with HPLC .
26773932	0	vildagliptin	109,121	DPP-4	8,13	vildagliptin	DPP-4	MESH:C502012	13482(Tax:10090)	Chemical	Gene	ameliorated|nmod|START_ENTITY reactions|acl:relcl|ameliorated up-regulates|dobj|reactions up-regulates|nsubj|END_ENTITY	Soluble DPP-4 up-regulates toll-like receptors and augments inflammatory reactions , which are ameliorated by vildagliptin or mannose-6-phosphate .
18931099	0	vildagliptin	37,49	Dipeptidyl_peptidase-4	0,22	vildagliptin	Dipeptidyl peptidase-4	MESH:C502012	1803	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|END_ENTITY	Dipeptidyl_peptidase-4 inhibition by vildagliptin and the effect on insulin secretion and action in response to meal ingestion in type 2 diabetes .
25195070	0	vildagliptin	34,46	Dipeptidyl_peptidase-4	0,22	vildagliptin	Dipeptidyl peptidase-4	MESH:C502012	13482(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Dipeptidyl_peptidase-4 inhibitor , vildagliptin , inhibits pancreatic beta cell apoptosis in association with its effects suppressing endoplasmic reticulum stress in db/db mice .
25204760	0	vildagliptin	34,46	Dipeptidyl_peptidase-4	0,22	vildagliptin	Dipeptidyl peptidase-4	MESH:C502012	1803	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Dipeptidyl_peptidase-4 inhibitor -LRB- vildagliptin -RRB- improves glycemic control after meal tolerance test by suppressing glucagon release .
16219012	0	vildagliptin	100,112	dipeptidyl_peptidase-4	32,54	vildagliptin	dipeptidyl peptidase-4	MESH:C502012	1803	Chemical	Gene	control|dep|START_ENTITY control|nmod|inhibition inhibition|amod|END_ENTITY	Improved glycaemic control with dipeptidyl_peptidase-4 inhibition in patients with type 2 diabetes : vildagliptin -LRB- LAF237 -RRB- dose response .
21437121	0	vildagliptin	83,95	dipeptidyl_peptidase-4	14,36	vildagliptin	dipeptidyl peptidase-4	MESH:C502012	1803	Chemical	Gene	use|nmod|START_ENTITY mechanisms|nmod|use Inhibition|dep|mechanisms Inhibition|nmod|END_ENTITY	Inhibition of dipeptidyl_peptidase-4 : The mechanisms of action and clinical use of vildagliptin for the management of type 2 diabetes .
22882290	0	vildagliptin	61,73	dipeptidyl_peptidase-4	28,50	vildagliptin	dipeptidyl peptidase-4	MESH:C502012	1803	Chemical	Gene	START_ENTITY|nsubj|Studies Studies|nmod|rodents rodents|nmod|inhibitor inhibitor|amod|END_ENTITY	Studies in rodents with the dipeptidyl_peptidase-4 inhibitor vildagliptin to evaluate possible drug-induced pancreatic histological changes that are predictive of pancreatitis and cancer development in man .
23990203	0	vildagliptin	179,191	dipeptidyl_peptidase-4	145,167	vildagliptin	dipeptidyl peptidase-4	MESH:C502012	1803	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Association between urinary albumin excretion and low-density lipoprotein heterogeneity following treatment of type 2 diabetes patients with the dipeptidyl_peptidase-4 inhibitor , vildagliptin : a pilot study .
17192459	0	vildagliptin	165,177	dipeptidyl_peptidase-IV	130,153	vildagliptin	dipeptidyl peptidase-IV	MESH:C502012	25253(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Liraglutide , a long-acting glucagon-like_peptide-1 analog , reduces body weight and food intake in obese candy-fed rats , whereas a dipeptidyl_peptidase-IV inhibitor , vildagliptin , does not .
17947341	0	vildagliptin	49,61	dipeptidyl_peptidase-IV	15,38	vildagliptin	dipeptidyl peptidase-IV	MESH:C502012	1803	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Effects of the dipeptidyl_peptidase-IV inhibitor vildagliptin on incretin hormones , islet function , and postprandial glycemia in subjects with impaired_glucose_tolerance .
21755761	0	vildagliptin	59,71	dipeptidyl_peptidase-IV	17,40	vildagliptin	dipeptidyl peptidase-IV	MESH:C502012	1803	Chemical	Gene	START_ENTITY|nsubj|role role|nmod|inhibitor inhibitor|compound|END_ENTITY	Emerging role of dipeptidyl_peptidase-IV -LRB- DPP-4 -RRB- inhibitor vildagliptin in the management of type 2 diabetes .
18042650	0	vildagliptin	96,108	dipeptidyl_peptidase_4	63,85	vildagliptin	dipeptidyl peptidase 4	MESH:C502012	1803	Chemical	Gene	START_ENTITY|nsubj|Measurements Measurements|nmod|function function|nmod|inhibitor inhibitor|amod|END_ENTITY	Measurements of islet function and glucose metabolism with the dipeptidyl_peptidase_4 inhibitor vildagliptin in patients with type 2 diabetes .
19074976	0	vildagliptin	15,27	dipeptidyl_peptidase_4	37,59	vildagliptin	dipeptidyl peptidase 4	MESH:C502012	25253(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Disposition of vildagliptin , a novel dipeptidyl_peptidase_4 inhibitor , in rats and dogs .
24521405	0	vildagliptin	10,22	dipeptidyl_peptidase_4	26,48	vildagliptin	dipeptidyl peptidase 4	MESH:C502012	25253(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effect of vildagliptin , a dipeptidyl_peptidase_4 inhibitor , on cardiac_hypertrophy induced by chronic beta-adrenergic stimulation in rats .
17244786	0	vildagliptin	38,50	dipeptidyl_peptidase_IV	4,27	vildagliptin	dipeptidyl peptidase IV	MESH:C502012	1803	Chemical	Gene	suppresses|compound|START_ENTITY suppresses|amod|END_ENTITY	The dipeptidyl_peptidase_IV inhibitor vildagliptin suppresses endogenous glucose production and enhances islet function after single-dose administration in type 2 diabetic patients .
17519080	0	vildagliptin	59,71	dipeptidyl_peptidase_IV	25,48	vildagliptin	dipeptidyl peptidase IV	MESH:C502012	1803	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|inhibitor inhibitor|compound|END_ENTITY	Effect of the novel oral dipeptidyl_peptidase_IV inhibitor vildagliptin on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects .
18793589	0	vildagliptin	108,120	dipeptidyl_peptidase_IV	74,97	vildagliptin	dipeptidyl peptidase IV	MESH:C502012	1803	Chemical	Gene	START_ENTITY|nsubj|Evaluation Evaluation|nmod|interaction interaction|nmod|inhibitor inhibitor|amod|END_ENTITY	Evaluation of pharmacokinetic and pharmacodynamic interaction between the dipeptidyl_peptidase_IV inhibitor vildagliptin , glyburide and pioglitazone in patients with Type 2 diabetes .
21609207	0	vildagliptin	36,48	dipeptidyl_peptidase_IV	52,75	vildagliptin	dipeptidyl peptidase IV	MESH:C502012	1803	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Thorough QT study of the effects of vildagliptin , a dipeptidyl_peptidase_IV inhibitor , on cardiac repolarization and conduction in healthy volunteers .
23378769	0	vildagliptin	12,24	insulin	45,52	vildagliptin	insulin	MESH:C502012	3630	Chemical	Gene	Efficacy|nmod|START_ENTITY Efficacy|nmod|END_ENTITY	Efficacy of vildagliptin in combination with insulin in patients with type 2 diabetes and severe renal_impairment .
7935998	0	vinblastine	108,119	IFN_alpha	69,78	vinblastine	IFN alpha	MESH:D014747	3439	Chemical	Gene	treated|nmod|START_ENTITY treated|nmod|END_ENTITY	Immune reactive proteins in renal_cell_carcinoma patients treated by IFN_alpha alone or in combination with vinblastine .
11585055	0	vinblastine	157,168	Jun	118,121	vinblastine	Jun	MESH:D014747	3725	Chemical	Gene	induced|nmod|START_ENTITY activation|acl|induced activation|nmod|END_ENTITY	AP-1 activation and altered AP-1 composition in association with increased phosphorylation and expression of specific Jun and Fos family proteins induced by vinblastine in KB-3 cells .
16739070	0	vinblastine	49,60	MDCK-MDR1	77,86	vinblastine	MDCK-MDR1	MESH:D014747	403879(Tax:9615)	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Conferone from Ferula schtschurowskiana enhances vinblastine cytotoxicity in MDCK-MDR1 cells by competitively inhibiting P-glycoprotein transport .
1671012	0	vinblastine	101,112	NPY	146,149	vinblastine	NPY	MESH:D014747	24604(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Detection of neuropeptide_Y-like_immunoreactivity and messenger RNA in rat platelets : the effects of vinblastine , reserpine , and dexamethasone on NPY expression in blood cells .
25332243	0	vinblastine	100,111	S0008	25,30	vinblastine	S0008	MESH:D014747	1076428(Tax:198215)	Chemical	Gene	trial|nmod|START_ENTITY END_ENTITY|dep|trial	Southwest Oncology Group S0008 : a phase III trial of high-dose interferon Alfa-2b versus cisplatin , vinblastine , and dacarbazine , plus interleukin-2 and interferon in patients with high-risk melanoma -- an intergroup study of cancer and leukemia Group B , Children 's Oncology Group , Eastern Cooperative Oncology Group , and Southwest Oncology Group .
16111654	0	vinblastine	67,78	c-Jun	8,13	vinblastine	c-Jun	MESH:D014747	3725	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of c-Jun in cellular sensitivity to the microtubule inhibitor vinblastine .
15701860	0	vinblastine	66,77	cyclooxygenase-2	10,26	vinblastine	cyclooxygenase-2	MESH:D014747	19225(Tax:10090)	Chemical	Gene	reduces|nmod|START_ENTITY reduces|nsubj|END_ENTITY	Targeting cyclooxygenase-2 reduces overt toxicity toward low-dose vinblastine and extends survival of juvenile mice with Friend_disease .
7935991	0	vinblastine	47,58	interleukin-2	13,26	vinblastine	interleukin-2	MESH:D014747	3558	Chemical	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	Subcutaneous interleukin-2 in combination with vinblastine for metastatic renal_cancer : cytolytic activity of peripheral blood lymphocytes .
1810152	0	vinblastine	11,22	neuropeptide_Y	26,40	vinblastine	neuropeptide Y	MESH:D014747	24604(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|amod|END_ENTITY	Effects of vinblastine on neuropeptide_Y levels in the sympathoadrenal system , bone marrow and thrombocytes of the rat .
732253	0	vinblastine	17,28	renin	47,52	vinblastine	renin	MESH:D014747	24715(Tax:10116)	Chemical	Gene	influence|nmod|START_ENTITY influence|nmod|secretion secretion|compound|END_ENTITY	The influence of vinblastine and colchicine on renin secretion in vivo and in vitro .
16555127	0	vinca_alkaloids	10,25	ERalpha	29,36	vinca alkaloids	ERalpha	MESH:D014748	2099	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Effect of vinca_alkaloids on ERalpha levels and estradiol-induced responses in MCF-7 cells .
18940246	0	vinclozolin	22,33	CD1	92,95	vinclozolin	CD1	MESH:C025643	111334(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|development development|nmod|END_ENTITY	Effect of low dose of vinclozolin on reproductive tract development and sperm parameters in CD1 outbred mice .
19968493	0	vincristine	41,52	Akt	22,25	vincristine	Akt	MESH:D014750	207	Chemical	Gene	contributes|xcomp|START_ENTITY contributes|nsubj|END_ENTITY	Constitutively active Akt contributes to vincristine resistance in human retinoblastoma cells .
20809973	0	vincristine	48,59	I-kappa-kinase-2	0,16	vincristine	I-kappa-kinase-2	MESH:D014750	16150(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|potentiates potentiates|amod|END_ENTITY	I-kappa-kinase-2 -LRB- IKK-2 -RRB- inhibition potentiates vincristine cytotoxicity in non-Hodgkin 's _ lymphoma .
19816010	0	vincristine	39,50	L-asparaginase	10,24	vincristine	L-asparaginase	MESH:D014750	80150	Chemical	Gene	combined|nmod|START_ENTITY combined|nsubj|Effect Effect|nmod|END_ENTITY	Effect of L-asparaginase combined with vincristine and prednisolone on acute_myeloblastic_leukemia -LRB- M0 -RRB- associated with non-Hodgkin_lymphoma .
22108005	0	vincristine	90,101	Mcl-1	136,141	vincristine	Mcl-1	MESH:D014750	4170	Chemical	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Autophagy-mediated HMGB1 release antagonizes apoptosis of gastric_cancer cells induced by vincristine via transcriptional regulation of Mcl-1 .
16117894	0	vincristine	32,43	NF-kappaB	71,80	vincristine	NF-kappaB	MESH:D014750	4790	Chemical	Gene	START_ENTITY|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Reversal of chemoresistance to vincristine in gastric_cancer cells by NF-kappaB inhibitor -RSB- .
10348798	0	vincristine	69,80	P-glycoprotein	21,35	vincristine	P-glycoprotein	MESH:D014750	287115(Tax:10116)	Chemical	Gene	disposition|nmod|START_ENTITY Effect|nmod|disposition Effect|nmod|PSC_833 PSC_833|appos|modulator modulator|amod|END_ENTITY	Effect of PSC_833 , a P-glycoprotein modulator , on the disposition of vincristine and digoxin in rats .
11113639	0	vincristine	16,27	P-glycoprotein	109,123	vincristine	P-glycoprotein	MESH:D014750	5243	Chemical	Gene	resistant|amod|START_ENTITY line|amod|resistant Evaluation|nmod|line Evaluation|acl|screening screening|nmod|interaction interaction|amod|END_ENTITY	Evaluation of a vincristine resistant Caco-2 cell line for use in a calcein_AM extrusion screening assay for P-glycoprotein interaction .
11989653	0	vincristine	123,134	P-glycoprotein	99,113	vincristine	P-glycoprotein	MESH:D014750	67078(Tax:10090)	Chemical	Gene	resistance|amod|START_ENTITY mediated|dobj|resistance mediated|nsubj|effect effect|nmod|inhibitors inhibitors|nmod|pathway pathway|nmod|END_ENTITY	Reversal effect of specific inhibitors of extracellular-signal_regulated_protein_kinase pathway on P-glycoprotein mediated vincristine resistance of L1210 cells .
1355756	0	vincristine	95,106	P-glycoprotein	19,33	vincristine	P-glycoprotein	MESH:D014750	5243	Chemical	Gene	resistance|amod|START_ENTITY selected|nmod|resistance selected|nsubj|Over-expression Over-expression|nmod|pi pi|amod|END_ENTITY	Over-expression of P-glycoprotein and glutathione_S-transferase pi in MCF-7 cells selected for vincristine resistance in vitro .
1672314	0	vincristine	84,95	P-glycoprotein	12,26	vincristine	P-glycoprotein	MESH:D014750	5243	Chemical	Gene	isolated|xcomp|START_ENTITY isolated|nsubj|Analysis Analysis|nmod|phosphorylation phosphorylation|amod|END_ENTITY	Analysis of P-glycoprotein phosphorylation in HL60 cells isolated for resistance to vincristine .
1972632	0	vincristine	66,77	P-glycoprotein	101,115	vincristine	P-glycoprotein	MESH:D014750	5243	Chemical	Gene	START_ENTITY|nmod|concentration concentration|nmod|absence absence|nmod|END_ENTITY	Verapamil and cyclosporin_A sensitize human kidney_tumor cells to vincristine in absence of membrane P-glycoprotein and without apparent changes in the cytoplasmic free Ca2 + concentration .
20929136	0	vincristine	174,185	P-glycoprotein	95,109	vincristine	P-glycoprotein	MESH:D014750	5243	Chemical	Gene	-RSB-|amod|START_ENTITY induced|nmod|-RSB- Effects|acl|induced Effects|nmod|END_ENTITY	-LSB- Effects of changwelqing on nuclear translocation of Y-box_binding_protein-1 and expression of P-glycoprotein in human colon_cancer cell line with drug-resistance induced by vincristine -RSB- .
26002042	0	vincristine	73,84	P-glycoprotein	142,156	vincristine	P-glycoprotein	MESH:D014750	5243	Chemical	Gene	cells|nmod|START_ENTITY upregulation|compound|cells upregulation|nmod|activity activity|amod|END_ENTITY	Selection of resistant acute_myeloid_leukemia SKM-1 and MOLM-13 cells by vincristine - , mitoxantrone - and lenalidomide-induced upregulation of P-glycoprotein activity and downregulation of CD33 cell surface exposure .
7654766	0	vincristine	106,117	P-glycoprotein	0,14	vincristine	P-glycoprotein	MESH:D014750	5243	Chemical	Gene	overdose|nmod|START_ENTITY treated|nmod|overdose cells|acl|treated hyperphosphorylated|nmod|cells hyperphosphorylated|nsubjpass|END_ENTITY	P-glycoprotein is hyperphosphorylated in multidrug resistant HOB1_lymphoma cells treated with overdose of vincristine .
7904199	0	vincristine	29,40	P-glycoprotein	102,116	vincristine	P-glycoprotein	MESH:D014750	5243	Chemical	Gene	efflux|nmod|START_ENTITY mediated|nsubjpass|efflux mediated|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- The efflux of intracellular vincristine in drug-resistant human lung_cancer cells is not mediated by P-glycoprotein -RSB- .
8846884	0	vincristine	69,80	P-glycoprotein	45,59	vincristine	P-glycoprotein	MESH:D014750	67078(Tax:10090)	Chemical	Gene	resistance|amod|START_ENTITY mediated|dobj|resistance mediated|nsubj|Effect Effect|nmod|phorbol_myristate_acetate phorbol_myristate_acetate|nmod|END_ENTITY	Effect of phorbol_myristate_acetate -LRB- PMA -RRB- on P-glycoprotein mediated vincristine resistance of L1210 cells .
20929136	0	vincristine	174,185	Y-box_binding_protein-1	53,76	vincristine	Y-box binding protein-1	MESH:D014750	4904	Chemical	Gene	-RSB-|amod|START_ENTITY induced|nmod|-RSB- Effects|acl|induced Effects|nmod|END_ENTITY	-LSB- Effects of changwelqing on nuclear translocation of Y-box_binding_protein-1 and expression of P-glycoprotein in human colon_cancer cell line with drug-resistance induced by vincristine -RSB- .
891791	0	vincristine	10,21	insulin	41,48	vincristine	insulin	MESH:D014750	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of vincristine on glucose-induced insulin secretion in man .
3501797	0	vincristine	42,53	interleukin-2	25,38	vincristine	interleukin-2	MESH:D014750	116562(Tax:10116)	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of release of interleukin-2 by vincristine and vinblastine .
21559677	0	vincristine	61,72	p-glycoprotein	13,27	vincristine	p-glycoprotein	MESH:D014750	5243	Chemical	Gene	mediated|nmod|START_ENTITY mediated|nsubj|Reversion Reversion|nmod|END_ENTITY	Reversion of p-glycoprotein mediated multidrug-resistance to vincristine and adriamycin by psc-833 , a cyclosporine derivative in human neuroblastoma cell-lines .
25981997	0	vindoline	68,77	b-cyclodextrin	11,25	vindoline	b-cyclodextrin	MESH:C009667	285440	Chemical	Gene	production|nmod|START_ENTITY END_ENTITY|nmod|production	Effects of b-cyclodextrin and methyl_jasmonate on the production of vindoline , catharanthine , and ajmalicine in Catharanthus roseus cambial meristematic cell cultures .
26483208	0	viniferin	30,39	SIRT1	140,145	viniferin	SIRT1	null	23411	Chemical	Gene	START_ENTITY|nmod|pathway pathway|compound|END_ENTITY	Protective effect of trans - - viniferin against high glucose-induced oxidative stress in human umbilical vein endothelial cells through the SIRT1 pathway .
12401903	0	vinorelbine	25,36	HER2	92,96	vinorelbine	HER2	MESH:C030852	2064	Chemical	Gene	START_ENTITY|nmod|therapy therapy|nmod|patients patients|nmod|END_ENTITY	Phase II trial of weekly vinorelbine and trastuzumab as first-line therapy in patients with HER2 -LRB- + -RRB- metastatic breast_cancer .
26034656	0	vinorelbine	48,59	HER2	107,111	vinorelbine	HER2	MESH:C030852	2064	Chemical	Gene	study|nmod|START_ENTITY study|advcl|overexpressing overexpressing|nsubj|therapy therapy|nmod|women women|nmod|END_ENTITY	Phase II study of lapatinib in combination with vinorelbine , as first or second-line therapy in women with HER2 overexpressing metastatic breast_cancer .
9744509	0	vinorelbine	51,62	granulocyte_colony-stimulating_factor	107,144	vinorelbine	granulocyte colony-stimulating factor	MESH:C030852	1440	Chemical	Gene	treatment|nmod|START_ENTITY treatment|nmod|END_ENTITY	Effective treatment of advanced_breast_cancer with vinorelbine , 5-fluorouracil and l-leucovorin plus human granulocyte_colony-stimulating_factor .
14562033	0	vinorelbine	48,59	p21	20,23	vinorelbine	p21	MESH:C030852	1026	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Unique induction of p21 -LRB- WAF1/CIP1 -RRB- expression by vinorelbine in androgen-independent prostate_cancer cells .
21172326	0	vinyl_chalcogenide	32,50	adenosine_deaminase	74,93	vinyl chalcogenide	adenosine deaminase	null	100	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	An in vitro comparison of a new vinyl_chalcogenide and sodium_selenate on adenosine_deaminase activity of human leukocytes .
612461	0	vinyl_chloride	53,67	CD-1	102,106	vinyl chloride	CD-1	MESH:D014752	111334(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|compound|END_ENTITY	Dominant lethal studies with the halogenated olefins vinyl_chloride and vinylidene_dichloride in male CD-1 mice .
13927	0	vinyl_chloride	39,53	Cytochrome_P-450	0,16	vinyl chloride	Cytochrome P-450	MESH:D014752	4051	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|amod|END_ENTITY	Cytochrome_P-450 and the metabolism of vinyl_chloride .
16603348	0	vinyl_ester	31,42	P3_and_P4	0,9	vinyl ester	P3 and P4	null	5394	Chemical	Gene	analysis|nmod|START_ENTITY analysis|amod|END_ENTITY	P3_and_P4 position analysis of vinyl_ester pseudopeptide proteasome inhibitors .
8216253	0	vinyl_sulfones	70,84	glyceraldehyde-3-phosphate_dehydrogenase	26,66	vinyl sulfones	glyceraldehyde-3-phosphate dehydrogenase	null	2597	Chemical	Gene	inactivation|nmod|START_ENTITY inactivation|nmod|END_ENTITY	Selective inactivation of glyceraldehyde-3-phosphate_dehydrogenase by vinyl_sulfones .
22330635	0	vinylcycloalkyl-substituted_benzimidazole	13,54	TRPM8	55,60	vinylcycloalkyl-substituted benzimidazole	TRPM8	null	171384(Tax:10116)	Chemical	Gene	antagonists|amod|START_ENTITY antagonists|compound|END_ENTITY	Discovery of vinylcycloalkyl-substituted_benzimidazole TRPM8 antagonists effective in the treatment of cold_allodynia .
18805772	0	vitamin-K_epoxide	24,41	VKORC1	53,59	vitamin-K epoxide	VKORC1	MESH:C016186	79001	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Haplogroup analysis of vitamin-K_epoxide reductase -LRB- VKORC1 -RRB- gene : novel element in the optimization of anticoagulant therapy -RSB- .
23481074	0	vitamin-K_epoxide	32,49	VKORC1	69,75	vitamin-K epoxide	VKORC1	MESH:C016186	79001	Chemical	Gene	polymorphisms|amod|START_ENTITY polymorphisms|amod|complex complex|dep|A A|compound|END_ENTITY	Cytochrome_P450 -LRB- CYP2C9 * 2 , * 3 -RRB- _ vitamin-K_epoxide reductase complex -LRB- VKORC1 -1639 G < A -RRB- gene polymorphisms _ their effect on acenocoumarol dose in patients with mechanical heart valve replacement .
20399082	0	vitamin-mineral	14,29	CRP	49,52	vitamin-mineral	CRP	null	1401	Chemical	Gene	supplementation|amod|START_ENTITY supplementation|nmod|END_ENTITY	The effect of vitamin-mineral supplementation on CRP and IL-6 : a systemic review and meta-analysis of randomised controlled trials .
16804311	0	vitamin_A	10,19	CD44	27,31	vitamin A	CD44	MESH:D014801	25406(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of vitamin_A on the CD44 expression in the small intestine of rats with obstructive_jaundice .
10487743	0	vitamin_A	52,61	Cellular_retinol-binding_protein_I	0,34	vitamin A	Cellular retinol-binding protein I	MESH:D014801	19659(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY essential|nmod|homeostasis essential|nsubj|END_ENTITY	Cellular_retinol-binding_protein_I is essential for vitamin_A homeostasis .
19107358	0	vitamin_A	14,23	IFN-gamma	40,49	vitamin A	IFN-gamma	MESH:D014801	3458	Chemical	Gene	START_ENTITY|nmod|secretion secretion|nmod|END_ENTITY	The effect of vitamin_A on secretion of IFN-gamma and IL-4 in A549 cells induced by Mycoplasma_pneumoniae .
21572021	0	vitamin_A	116,125	IFN-gamma	0,9	vitamin A	IFN-gamma	MESH:D014801	15978(Tax:10090)	Chemical	Gene	absence|nmod|START_ENTITY node|nmod|absence IgG|nmod|node leads|xcomp|IgG leads|nsubj|cells cells|amod|END_ENTITY	IFN-gamma secreted by CD103 + dendritic cells leads to IgG generation in the mesenteric lymph node in the absence of vitamin_A .
17451418	0	vitamin_A	51,60	Nanog	88,93	vitamin A	Nanog	MESH:D014801	79923	Chemical	Gene	START_ENTITY|nmod|overexpression overexpression|nmod|END_ENTITY	Suppression of ES cell differentiation by retinol -LRB- vitamin_A -RRB- via the overexpression of Nanog .
3191561	0	vitamin_A	72,81	Ornithine_decarboxylase	0,23	vitamin A	Ornithine decarboxylase	MESH:D014801	24609(Tax:10116)	Chemical	Gene	rats|compound|START_ENTITY activity|nmod|rats END_ENTITY|dobj|activity	Ornithine_decarboxylase basal activity in liver , oesophagus and lung of vitamin_A deficient rats , and the effect of retinoic_acid .
12576510	0	vitamin_A	19,28	PPARbeta	0,8	vitamin A	PPARbeta	MESH:D014801	5467	Chemical	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	PPARbeta regulates vitamin_A metabolism-related gene expression in hepatic stellate cells undergoing activation .
2108233	0	vitamin_A	43,52	Plasma_retinol-binding_protein	0,30	vitamin A	Plasma retinol-binding protein	MESH:D014801	5950	Chemical	Gene	administration|compound|START_ENTITY response|nmod|administration response|amod|END_ENTITY	Plasma_retinol-binding_protein response to vitamin_A administration in infants susceptible to bronchopulmonary_dysplasia .
24803603	0	vitamin_A	95,104	RBP	73,76	vitamin A	RBP	MESH:D014801	5950	Chemical	Gene	uptake|compound|START_ENTITY uptake|compound|END_ENTITY	Reply to `` How free retinol behaves differently from RBP-bound retinol in RBP receptor-mediated vitamin_A uptake '' .
4039596	0	vitamin_A	18,27	RBP	53,56	vitamin A	RBP	MESH:D014801	5950	Chemical	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	-LSB- Plasma levels of vitamin_A and its protein vectors -LRB- RBP and PA -RRB- , carotene , total cholesterol and HDL-cholesterol in healthy adults of the female sex -RSB- .
4039597	0	vitamin_A	18,27	RBP	53,56	vitamin A	RBP	MESH:D014801	5950	Chemical	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	-LSB- Plasma levels of vitamin_A and its protein vectors -LRB- RBP and PA -RRB- , carotene , total cholesterol and cholesterol-HDL in patients with dysplasia of the uterine cervix -RSB- .
4039598	0	vitamin_A	18,27	RBP	53,56	vitamin A	RBP	MESH:D014801	5950	Chemical	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	-LSB- Plasma levels of vitamin_A and its protein vectors -LRB- RBP and PA -RRB- , carotene , total cholesterol and HDL-cholesterol in patients with carcinoma_of_the_cervix -RSB- .
7965197	0	vitamin_A	69,78	Retinoic_acid_receptor-alpha	0,28	vitamin A	Retinoic acid receptor-alpha	MESH:D014801	395213(Tax:9031)	Chemical	Gene	modulated|nmod|START_ENTITY modulated|nsubjpass|expression expression|amod|END_ENTITY	Retinoic_acid_receptor-alpha gene expression is modulated by dietary vitamin_A and by retinoic_acid in chicken T lymphocytes .
5675424	0	vitamin_A	51,60	Retinol-binding_protein	0,23	vitamin A	Retinol-binding protein	MESH:D014801	5950	Chemical	Gene	protein|nmod|START_ENTITY END_ENTITY|dep|protein	Retinol-binding_protein : the transport protein for vitamin_A in human plasma .
2759191	0	vitamin_A	67,76	Rhodopsin	0,9	vitamin A	Rhodopsin	MESH:D014801	493762(Tax:9685)	Chemical	Gene	deficiency|compound|START_ENTITY function|nmod|deficiency function|nsubj|levels levels|compound|END_ENTITY	Rhodopsin levels and retinal function in cats during recovery from vitamin_A deficiency .
8617875	0	vitamin_A	43,52	TGF-alpha	14,23	vitamin A	TGF-alpha	MESH:D014801	7039	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Inhibition of TGF-alpha gene expression by vitamin_A in airway epithelium .
121247	0	vitamin_A	62,71	cytochrome_P_450	89,105	vitamin A	cytochrome P 450	MESH:D014801	25251(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of alpha-tocopherol -LRB- vitamin_E -RRB- on the utilization of vitamin_A and induction of cytochrome_P_450 in rats receiving DDT -RSB- .
1572702	0	vitamin_A	29,38	interleukin-6	12,25	vitamin A	interleukin-6	MESH:D014801	3569	Chemical	Gene	deficiency|compound|START_ENTITY END_ENTITY|nmod|deficiency	The role of interleukin-6 in vitamin_A deficiency during Plasmodium_falciparum malaria and possible consequences for vitamin_A supplementation .
8504149	0	vitamin_A	8,17	lecithin-retinol_acyltransferase	28,60	vitamin A	lecithin-retinol acyltransferase	MESH:D014801	422403(Tax:9031)	Chemical	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activity activity|amod|END_ENTITY	Dietary vitamin_A modulates lecithin-retinol_acyltransferase activity in developing chick intestine .
23188981	0	vitamin_A	14,23	myelin_oligodendrocyte_glycoprotein	80,115	vitamin A	myelin oligodendrocyte glycoprotein	MESH:D014801	4340	Chemical	Gene	effect|nmod|START_ENTITY supplementation|nsubj|effect supplementation|nmod|END_ENTITY	The effect of vitamin_A supplementation on stimulated T-cell proliferation with myelin_oligodendrocyte_glycoprotein in patients with multiple_sclerosis .
6770209	0	vitamin_A	21,30	ornithine_decarboxylase	49,72	vitamin A	ornithine decarboxylase	MESH:D014801	4953	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Antitumor effects of vitamin_A and inhibitors of ornithine_decarboxylase in cultured neuroblastoma and glioma cells .
8398182	0	vitamin_A	42,51	proline-rich_protein	8,28	vitamin A	proline-rich protein	MESH:D014801	100736978	Chemical	Gene	regulated|nmod|START_ENTITY END_ENTITY|acl|regulated	A small proline-rich_protein regulated by vitamin_A in tracheal epithelial cells is induced in lung_tumors .
10953676	0	vitamin_A	74,83	retinol-binding_protein	11,34	vitamin A	retinol-binding protein	MESH:D014801	5950	Chemical	Gene	status|compound|START_ENTITY assessment|nmod|status ratio|nmod|assessment Use|dep|ratio Use|nmod|END_ENTITY	Use of the retinol-binding_protein : transthyretin ratio for assessment of vitamin_A status during the acute-phase response .
14585313	0	vitamin_A	67,76	retinol-binding_protein	40,63	vitamin A	retinol-binding protein	MESH:D014801	19662(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY Understanding|nmod|metabolism Understanding|dobj|role role|nmod|END_ENTITY	Understanding the physiological role of retinol-binding_protein in vitamin_A metabolism using transgenic and knockout mouse models .
15588697	0	vitamin_A	102,111	retinol-binding_protein	28,51	vitamin A	retinol-binding protein	MESH:D014801	5950	Chemical	Gene	homeostasis|compound|START_ENTITY implications|nmod|homeostasis END_ENTITY|dep|implications	Interactions amongst plasma retinol-binding_protein , transthyretin and their ligands : implications in vitamin_A homeostasis and transthyretin_amyloidosis .
19474143	0	vitamin_A	137,146	retinol-binding_protein	61,84	vitamin A	retinol-binding protein	MESH:D014801	5950	Chemical	Gene	stores|compound|START_ENTITY determining|dobj|stores based|advcl|determining based|nmod|END_ENTITY	Assessment of the relative dose-response test based on serum retinol-binding_protein instead of serum retinol in determining low hepatic vitamin_A stores .
2321569	0	vitamin_A	55,64	retinol-binding_protein	28,51	vitamin A	retinol-binding protein	MESH:D014801	5950	Chemical	Gene	status|compound|START_ENTITY Regulation|nmod|status Regulation|nmod|END_ENTITY	Regulation of metabolism of retinol-binding_protein by vitamin_A status in children with biliary_atresia .
2323047	0	vitamin_A	81,90	retinol-binding_protein	36,59	vitamin A	retinol-binding protein	MESH:D014801	5950	Chemical	Gene	status|compound|START_ENTITY tests|nmod|status serum|nmod|tests END_ENTITY|nmod|serum	Use of free and transthyretin-bound retinol-binding_protein in serum as tests of vitamin_A status in humans : effect of high creatinine concentrations in serum .
7551819	0	vitamin_A	68,77	retinol-binding_protein	32,55	vitamin A	retinol-binding protein	MESH:D014801	5950	Chemical	Gene	administration|compound|START_ENTITY response|nmod|administration response|amod|END_ENTITY	Sequential evaluation of plasma retinol-binding_protein response to vitamin_A administration in very-low-birth-weight neonates .
9314576	0	vitamin_A	68,77	retinol-binding_protein	2,25	vitamin A	retinol-binding protein	MESH:D014801	25703(Tax:10116)	Chemical	Gene	mechanism|nmod|START_ENTITY mechanism|amod|END_ENTITY	A retinol-binding_protein receptor-mediated mechanism for uptake of vitamin_A to postimplantation rat embryos .
13011282	0	vitamin_A	21,30	rhodopsin	51,60	vitamin A	rhodopsin	MESH:D014801	6010	Chemical	Gene	isomers|nmod|START_ENTITY isomers|nmod|system system|compound|END_ENTITY	Cis-trans isomers of vitamin_A and retinene in the rhodopsin system .
9751768	0	vitamin_A	10,19	rhodopsin	39,48	vitamin A	rhodopsin	MESH:D014801	212541(Tax:10090)	Chemical	Gene	supplementation|compound|START_ENTITY supplementation|nmod|_ _|amod|END_ENTITY	Effect of vitamin_A supplementation on rhodopsin mutants threonine-17 _ -- > _ methionine and proline-347 _ -- > _ serine in transgenic_mice and in cell cultures .
11970916	0	vitamin_A	45,54	thioredoxin	14,25	vitamin A	thioredoxin	MESH:D014801	7295	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Regulation of thioredoxin gene expression by vitamin_A in human airway epithelial cells .
11780467	0	vitamin_A	18,27	tyrosinase	31,41	vitamin A	tyrosinase	MESH:D014801	7299	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|amod|END_ENTITY	Effects of acidum vitamin_A on tyrosinase activity .
2864042	0	vitamin_B-6	10,21	elastin	54,61	vitamin B-6	elastin	MESH:D025101	25043(Tax:10116)	Chemical	Gene	deficiency|amod|START_ENTITY deficiency|nmod|END_ENTITY	Effect of vitamin_B-6 -LRB- pyridoxine -RRB- deficiency on lung elastin cross-linking in perinatal and weanling rat pups .
13681399	0	vitamin_B12	35,46	B12	87,90	vitamin B12	B12	MESH:D014805	4709	Chemical	Gene	excretion|nmod|START_ENTITY excretion|nmod|END_ENTITY	The urinary excretion of assayable vitamin_B12 and radioactivity after parenteral 58Co B12 in man .
22770998	0	vitamin_B12	66,77	Cbl	79,82	vitamin B12	Cbl	MESH:D014805	867	Chemical	Gene	deficiency|amod|START_ENTITY deficiency|appos|END_ENTITY	Recommendations for diagnosis and management of metformin-induced vitamin_B12 -LRB- Cbl -RRB- deficiency .
24122983	0	vitamin_B12	42,53	TCII	73,77	vitamin B12	TCII	MESH:D014805	6948	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Immunohistochemical quantification of the vitamin_B12 transport protein -LRB- TCII -RRB- , cell_surface_receptor -LRB- TCII-R -RRB- and Ki-67 in human tumor xenografts .
19776636	0	vitamin_B12	92,103	cystathionine_beta-synthase	32,59	vitamin B12	cystathionine beta-synthase	MESH:D014805	24250(Tax:10116)	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Change of epigenetic control of cystathionine_beta-synthase gene expression through dietary vitamin_B12 is not recovered by methionine supplementation .
16818564	0	vitamin_B12	56,67	erythropoietin	82,96	vitamin B12	erythropoietin	MESH:D014805	2056	Chemical	Gene	adding|dobj|START_ENTITY adding|nmod|END_ENTITY	A randomized , controlled trial of the effects of adding vitamin_B12 and folate to erythropoietin for the treatment of anemia of prematurity .
16613998	0	vitamin_B12	10,21	haptocorrin	35,46	vitamin B12	haptocorrin	MESH:D014805	6947	Chemical	Gene	treatment|amod|START_ENTITY Effect|nmod|treatment Effect|nmod|END_ENTITY	Effect of vitamin_B12 treatment on haptocorrin .
1175581	0	vitamin_B12	27,38	intrinsic_factor	59,75	vitamin B12	intrinsic factor	MESH:D014805	29319(Tax:10116)	Chemical	Gene	capacity|amod|START_ENTITY capacity|nmod|END_ENTITY	Effect of X-irradiation on vitamin_B12 binding capacity to intrinsic_factor .
14576052	0	vitamin_B12	26,37	intrinsic_factor	39,55	vitamin B12	intrinsic factor	MESH:D014805	2694	Chemical	Gene	cobalamin|appos|START_ENTITY cobalamin|dep|receptor receptor|compound|END_ENTITY	The functional cobalamin -LRB- vitamin_B12 -RRB- - intrinsic_factor receptor is a novel complex of cubilin and amnionless .
16704961	0	vitamin_B12	66,77	intrinsic_factor	32,48	vitamin B12	intrinsic factor	MESH:D014805	2694	Chemical	Gene	uptake|nmod|START_ENTITY effect|nmod|uptake effect|nmod|END_ENTITY	The effect of recombinant human intrinsic_factor on the uptake of vitamin_B12 in patients with evident vitamin_B12_deficiency .
26547268	0	vitamin_B12	111,122	intrinsic_factor	78,94	vitamin B12	intrinsic factor	MESH:D014805	2694	Chemical	Gene	population|amod|START_ENTITY Comparison|nmod|population Comparison|nmod|determination determination|nmod|antibodies antibodies|compound|END_ENTITY	Comparison of five commercially available ELISA kits for the determination of intrinsic_factor antibodies in a vitamin_B12 deficient adult population .
4163907	0	vitamin_B12	44,55	intrinsic_factor	10,26	vitamin B12	intrinsic factor	MESH:D014805	2694	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of intrinsic_factor on absorption of vitamin_B12 from small intestine .
7218021	0	vitamin_B12	31,42	intrinsic_factor	77,93	vitamin B12	intrinsic factor	MESH:D014805	2694	Chemical	Gene	significance|nmod|START_ENTITY measured|nsubj|significance measured|advcl|using using|dobj|END_ENTITY	Clinical significance of serum vitamin_B12 measured by radioassay using pure intrinsic_factor .
7240422	0	vitamin_B12	20,31	intrinsic_factor	71,87	vitamin B12	intrinsic factor	MESH:D014805	2694	Chemical	Gene	Comparison|nmod|START_ENTITY estimation|nsubj|Comparison estimation|nmod|END_ENTITY	Comparison of serum vitamin_B12 estimation by saturation analysis with intrinsic_factor and with R-protein as binding agents .
7470641	0	vitamin_B12	65,76	intrinsic_factor	116,132	vitamin B12	intrinsic factor	MESH:D014805	2694	Chemical	Gene	labelled|nsubj|START_ENTITY labelled|dobj|vitamin_B12 vitamin_B12|acl|bound bound|xcomp|END_ENTITY	Clinical evaluation of simultaneously administered 58Co labelled vitamin_B12 and 57Co labelled vitamin_B12 bound to intrinsic_factor in patients with pernicious anaemia .
7470641	0	vitamin_B12	95,106	intrinsic_factor	116,132	vitamin B12	intrinsic factor	MESH:D014805	2694	Chemical	Gene	START_ENTITY|acl|bound bound|xcomp|END_ENTITY	Clinical evaluation of simultaneously administered 58Co labelled vitamin_B12 and 57Co labelled vitamin_B12 bound to intrinsic_factor in patients with pernicious anaemia .
974875	0	vitamin_B12	61,72	intrinsic_factor	75,91	vitamin B12	intrinsic factor	MESH:D014805	29319(Tax:10116)	Chemical	Gene	complex|amod|START_ENTITY complex|compound|END_ENTITY	Lack of effect of alcohol on small intestinal binding of the vitamin_B12 - intrinsic_factor complex .
23415654	0	vitamin_B12	34,45	methionine_synthase	110,129	vitamin B12	methionine synthase	MESH:D014805	81522(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Molecular and cellular effects of vitamin_B12 in brain , myocardium and liver through its role as co-factor of methionine_synthase .
16489563	0	vitamin_B12	88,99	methylenetetrahydrofolate_reductase	22,57	vitamin B12	methylenetetrahydrofolate reductase	MESH:D014805	4524	Chemical	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	677TT polymorphism of methylenetetrahydrofolate_reductase in combination with low serum vitamin_B12 is associated with coronary_in-stent_restenosis .
22661206	0	vitamin_B12	8,19	methylmalonyl-CoA_mutase	23,47	vitamin B12	methylmalonyl-CoA mutase	MESH:D014805	4594	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|activity activity|amod|END_ENTITY	Role of vitamin_B12 on methylmalonyl-CoA_mutase activity .
11259691	0	vitamin_B12	8,19	transcobalamin_II	31,48	vitamin B12	transcobalamin II	MESH:D014805	6948	Chemical	Gene	START_ENTITY|amod|binding binding|nmod|END_ENTITY	Reduced vitamin_B12 binding by transcobalamin_II increases the risk of neural_tube_defects .
12239	0	vitamin_B12	14,25	transcobalamin_II	37,54	vitamin B12	transcobalamin II	MESH:D014805	6948	Chemical	Gene	START_ENTITY|amod|binding binding|nmod|END_ENTITY	Inhibition of vitamin_B12 binding to transcobalamin_II at low pH : basis of a procedure for quantitation of circulating TC_II and R binders .
1245601	0	vitamin_B12	83,94	transcobalamin_II	38,55	vitamin B12	transcobalamin II	MESH:D014805	6948	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role and fate of rabbit and human transcobalamin_II in the plasma transport of vitamin_B12 in the rabbit .
1268096	0	vitamin_B12	38,49	transcobalamin_II	123,140	vitamin B12	transcobalamin II	MESH:D014805	100358905(Tax:9986)	Chemical	Gene	proteins|amod|START_ENTITY circulating|dobj|proteins abnormality|acl|circulating abnormality|dep|occurrence occurrence|nmod|family family|nmod|concentrations concentrations|nmod|END_ENTITY	A familial abnormality of circulating vitamin_B12 binding proteins : occurrence in a family of high serum concentrations of transcobalamin_II .
373791	0	vitamin_B12	32,43	transcobalamin_II	13,30	vitamin B12	transcobalamin II	MESH:D014805	100734760	Chemical	Gene	incubation|amod|START_ENTITY vitamin_B12|dep|incubation vitamin_B12|amod|END_ENTITY	Formation of transcobalamin_II -- vitamin_B12 complex by guinea-pig ileal mucosa in organ culture after in vivo incubation with intrinsic factor -- vitamin_B12 .
3857911	0	vitamin_B12	33,44	transcobalamin_II	62,79	vitamin B12	transcobalamin II	MESH:D014805	21452(Tax:10090)	Chemical	Gene	protein|amod|START_ENTITY gene|nmod|protein Localization|nmod|gene linked|nsubj|Localization linked|nsubj|END_ENTITY	Localization of the gene for the vitamin_B12 binding protein , transcobalamin_II , near the centromere on mouse chromosome 11 , linked with the hemoglobin_alpha-chain locus .
8213000	0	vitamin_B12	46,57	transcobalamin_II	67,84	vitamin B12	transcobalamin II	MESH:D014805	6948	Chemical	Gene	measurement|nmod|START_ENTITY Method|nmod|measurement bound|csubj|Method bound|nmod|END_ENTITY	Method for the direct specific measurement of vitamin_B12 bound to transcobalamin_II in plasma .
907799	0	vitamin_B12	38,49	transcobalamin_II	17,34	vitamin B12	transcobalamin II	MESH:D014805	21452(Tax:10090)	Chemical	Gene	protein|amod|START_ENTITY END_ENTITY|appos|protein	The synthesis of transcobalamin_II , a vitamin_B12 transport protein , by stimulated mouse peritoneal macrophages .
4174292	0	vitamin_B12	4,15	transcobalamin_I_and_II	36,59	vitamin B12	transcobalamin I and II	MESH:D014805	6948	Chemical	Gene	capacity|amod|START_ENTITY capacity|nmod|END_ENTITY	The vitamin_B12 binding capacity of transcobalamin_I_and_II of normal human serum .
6449239	0	vitamin_B_12	82,94	Cb_1	96,100	vitamin B 12	Cb 1	MESH:D014805	1268	Chemical	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Role of pancreatic enzymes in the intraluminal transport and ileal absorption of vitamin_B_12 -LRB- Cb_1 -RRB- -RSB- .
22210726	0	vitamin_C	78,87	Cytochrome_c	0,12	vitamin C	Cytochrome c	MESH:D001205	54205	Chemical	Gene	interaction|nmod|START_ENTITY END_ENTITY|dep|interaction	Cytochrome_c : electron emission , photodegradation and mutual interaction with vitamin_C .
11834736	0	vitamin_C	144,153	GLUT2	108,113	vitamin C	GLUT2	MESH:D001205	25351(Tax:10116)	Chemical	Gene	transporters|nmod|START_ENTITY inhibition|appos|transporters inhibition|nmod|sodium-dependent_vitamin_C_transporter_1 sodium-dependent_vitamin_C_transporter_1|appos|END_ENTITY	Flavonoid inhibition of sodium-dependent_vitamin_C_transporter_1 -LRB- SVCT1 -RRB- and glucose_transporter_isoform_2 -LRB- GLUT2 -RRB- , intestinal transporters for vitamin_C and Glucose .
10467707	0	vitamin_C	72,81	GULO	41,45	vitamin C	GULO	MESH:D001205	396759(Tax:9823)	Chemical	Gene	deficiency|amod|START_ENTITY candidate|nmod|deficiency gene|acl:relcl|candidate gene|appos|END_ENTITY	The L-gulono-gamma-lactone_oxidase gene -LRB- GULO -RRB- which is a candidate for vitamin_C deficiency in pigs maps to chromosome 14 .
20547159	0	vitamin_C	61,70	Glucose_transporter_10	0,22	vitamin C	Glucose transporter 10	MESH:D001205	81031	Chemical	Gene	connection|amod|START_ENTITY END_ENTITY|dep|connection	Glucose_transporter_10 and arterial_tortuosity_syndrome : the vitamin_C connection .
18764764	0	vitamin_C	15,24	Gulo	49,53	vitamin C	Gulo	MESH:D001205	268756(Tax:10090)	Chemical	Gene	synthesis|amod|START_ENTITY synthesis|nmod|END_ENTITY	Restoration of vitamin_C synthesis in transgenic Gulo - / - mice by helper-dependent adenovirus-based expression of gulonolactone_oxidase .
21360155	0	vitamin_C	23,32	Gulo	47,51	vitamin C	Gulo	MESH:D001205	268756(Tax:10090)	Chemical	Gene	deficiency|amod|START_ENTITY deficiency|nmod|END_ENTITY	Metabolic profiling of vitamin_C deficiency in Gulo - / - mice using proton NMR spectroscopy .
22296218	0	vitamin_C	10,19	Gulo	103,107	vitamin C	Gulo	MESH:D001205	268756(Tax:10090)	Chemical	Gene	deficiency|amod|START_ENTITY Effect|nmod|deficiency Effect|dep|phenotype phenotype|nmod|END_ENTITY	Effect of vitamin_C deficiency during postnatal development on adult behavior : functional phenotype of Gulo - / - knockout mice .
26057690	0	vitamin_C	27,36	Gulo	93,97	vitamin C	Gulo	MESH:D001205	268756(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|cholestatic_liver_injury cholestatic_liver_injury|nmod|END_ENTITY	Hepatoprotective effect of vitamin_C on lithocholic_acid-induced cholestatic_liver_injury in Gulo -LRB- - / - -RRB- mice .
16414578	0	vitamin_C	101,110	N-bromosuccinimide	30,48	vitamin C	N-bromosuccinimide	MESH:D001205	4683	Chemical	Gene	evaluation|nmod|START_ENTITY evaluation|nmod|END_ENTITY	Statistical evaluation of the N-bromosuccinimide and Iodine as titrimetric methods for estimation of vitamin_C in orange juice and pharmaceutical preparations .
9923964	0	vitamin_C	10,19	PC3	67,70	vitamin C	PC3	MESH:D001205	57332	Chemical	Gene	cells|amod|START_ENTITY cells|appos|END_ENTITY	Effect of vitamin_C on androgen independent prostate_cancer cells -LRB- PC3 and Mat-Ly-Lu -RRB- in vitro : involvement of reactive oxygen species-effect on cell number , viability and DNA synthesis .
18791929	0	vitamin_C	38,47	SLC23A1	61,68	vitamin C	SLC23A1	MESH:D001205	9963	Chemical	Gene	variation|nmod|START_ENTITY transporters|nsubj|variation transporters|dobj|END_ENTITY	Genetic variation in sodium-dependent vitamin_C transporters SLC23A1 and SLC23A2 and risk of advanced colorectal_adenoma .
20519558	0	vitamin_C	105,114	SLC23A1	25,32	vitamin C	SLC23A1	MESH:D001205	9963	Chemical	Gene	concentrations|nmod|START_ENTITY circulating|dobj|concentrations associated|advcl|circulating associated|nsubjpass|variation variation|nmod|locus locus|nummod|END_ENTITY	Genetic variation at the SLC23A1 locus is associated with circulating concentrations of L-ascorbic_acid -LRB- vitamin_C -RRB- : evidence from 5 independent studies with > 15,000 participants .
23737080	0	vitamin_C	71,80	SLC23A1	28,35	vitamin C	SLC23A1	MESH:D001205	9963	Chemical	Gene	levels|amod|START_ENTITY polymorphisms|dobj|levels polymorphisms|nsubj|gene gene|appos|END_ENTITY	Vitamin_C transporter gene -LRB- SLC23A1 and SLC23A2 -RRB- polymorphisms , plasma vitamin_C levels , and gastric_cancer risk in the EPIC cohort .
24124560	0	vitamin_C	63,72	SLC23A1	92,99	vitamin C	SLC23A1	MESH:D001205	9963	Chemical	Gene	SVCT1|amod|START_ENTITY SVCT1|appos|END_ENTITY	Expression , purification and low-resolution structure of human vitamin_C transporter SVCT1 -LRB- SLC23A1 -RRB- .
24708273	0	vitamin_C	38,47	SLC23A1	0,7	vitamin C	SLC23A1	MESH:D001205	9963	Chemical	Gene	SVCT1|amod|START_ENTITY rs6596473|nmod|SVCT1 rs6596473|nummod|END_ENTITY	SLC23A1 polymorphism rs6596473 in the vitamin_C transporter SVCT1 is associated with aggressive periodontitis .
11584081	0	vitamin_C	55,64	SLC23A2	84,91	vitamin C	SLC23A2	MESH:D001205	9962	Chemical	Gene	SVCT1|amod|START_ENTITY SVCT1|appos|END_ENTITY	Characterization of the genomic structure of the human vitamin_C transporter SVCT1 -LRB- SLC23A2 -RRB- .
16380174	0	vitamin_C	74,83	SLC23A2	99,106	vitamin C	SLC23A2	MESH:D001205	9962	Chemical	Gene	START_ENTITY|dep|transporter transporter|nummod|END_ENTITY	Functional analysis of two regulatory regions of the human Na + - dependent vitamin_C transporter 2 , SLC23A2 , in human vascular smooth muscle cells .
10631088	0	vitamin_C	6,15	SVCT1	46,51	vitamin C	SVCT1	MESH:D001205	9963	Chemical	Gene	transporter|nsubj|START_ENTITY transporter|dobj|END_ENTITY	Human vitamin_C -LRB- L-ascorbic_acid -RRB- transporter SVCT1 .
10978367	0	vitamin_C	60,69	SVCT1	92,97	vitamin C	SVCT1	MESH:D001205	9963	Chemical	Gene	transporters|amod|START_ENTITY coding|nmod|transporters coding|dobj|1 1|appos|END_ENTITY	Mapping of the human genes -LRB- SLC23A2 and SLC23A1 -RRB- coding for vitamin_C transporters 1 and 2 -LRB- SVCT1 and SVCT2 -RRB- to 5q23 and 20p12 , respectively .
11834736	0	vitamin_C	144,153	SVCT1	66,71	vitamin C	SVCT1	MESH:D001205	50621(Tax:10116)	Chemical	Gene	transporters|nmod|START_ENTITY inhibition|appos|transporters inhibition|nmod|sodium-dependent_vitamin_C_transporter_1 sodium-dependent_vitamin_C_transporter_1|appos|END_ENTITY	Flavonoid inhibition of sodium-dependent_vitamin_C_transporter_1 -LRB- SVCT1 -RRB- and glucose_transporter_isoform_2 -LRB- GLUT2 -RRB- , intestinal transporters for vitamin_C and Glucose .
11895172	0	vitamin_C	28,37	SVCT1	50,55	vitamin C	SVCT1	MESH:D001205	9963	Chemical	Gene	transporter|amod|START_ENTITY expression|nmod|transporter END_ENTITY|nsubj|expression	Decreased expression of the vitamin_C transporter SVCT1 by ascorbic_acid in a human intestinal epithelial cell line .
15993839	0	vitamin_C	26,35	SVCT1	50,55	vitamin C	SVCT1	MESH:D001205	9963	Chemical	Gene	transporters|amod|START_ENTITY transporters|appos|END_ENTITY	Polarized localization of vitamin_C transporters , SVCT1 and SVCT2 , in epithelial cells .
17541511	0	vitamin_C	34,43	SVCT1	0,5	vitamin C	SVCT1	MESH:D001205	9963	Chemical	Gene	uptake|amod|START_ENTITY proteins|nmod|uptake END_ENTITY|dep|proteins	SVCT1 and SVCT2 : key proteins for vitamin_C uptake .
18094143	0	vitamin_C	58,67	SVCT1	81,86	vitamin C	SVCT1	MESH:D001205	9963	Chemical	Gene	L-ascorbic_acid|dep|START_ENTITY L-ascorbic_acid|dep|END_ENTITY	Transport model of the human Na + - coupled L-ascorbic_acid -LRB- vitamin_C -RRB- transporter SVCT1 .
19216494	0	vitamin_C	119,128	SVCT1	143,148	vitamin C	SVCT1	MESH:D001205	9963	Chemical	Gene	transporters|amod|START_ENTITY transporters|appos|END_ENTITY	Hierarchal contribution of N - and C-terminal sequences to the differential localization of homologous sodium-dependent vitamin_C transporters , SVCT1 and SVCT2 , in epithelial cells .
20541602	0	vitamin_C	4,13	SVCT2	121,126	vitamin C	SVCT2	MESH:D001205	54338(Tax:10090)	Chemical	Gene	Low|amod|START_ENTITY oxidative|nsubj|Low oxidative|nmod|mice mice|acl:relcl|lack lack|dobj|END_ENTITY	Low vitamin_C and increased oxidative stress and cell death in mice that lack the sodium-dependent_vitamin_C_transporter SVCT2 .
23321552	0	vitamin_C	9,18	SVCT2	71,76	vitamin C	SVCT2	MESH:D001205	54338(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|motor_defects motor_defects|nmod|mice mice|amod|END_ENTITY	Combined vitamin_C and E deficiency induces motor_defects in gulo -LRB- - / - -RRB- / SVCT2 -LRB- + / - -RRB- mice .
23964197	0	vitamin_C	6,15	SVCT2	0,5	vitamin C	SVCT2	MESH:D001205	9962	Chemical	Gene	expression|amod|START_ENTITY expression|nummod|END_ENTITY	SVCT2 vitamin_C transporter expression in progenitor cells of the postnatal neurogenic niche .
25102111	0	vitamin_C	48,57	SVCT2	85,90	vitamin C	SVCT2	MESH:D001205	9962	Chemical	Gene	system|amod|START_ENTITY expression|nmod|system expression|appos|END_ENTITY	Molecular expression and functional activity of vitamin_C specific transport system -LRB- SVCT2 -RRB- in human breast_cancer cells .
11984597	0	vitamin_C	51,60	Slc23a1	26,33	vitamin C	Slc23a1	MESH:D001205	20522(Tax:10090)	Chemical	Gene	transport|amod|START_ENTITY essential|nmod|transport essential|nsubj|END_ENTITY	Ascorbic-acid transporter Slc23a1 is essential for vitamin_C transport into the brain and for perinatal survival .
16736996	0	vitamin_C	74,83	angiotensin-converting_enzyme	25,54	vitamin C	angiotensin-converting enzyme	MESH:D001205	1636	Chemical	Gene	inhibitor|dep|START_ENTITY inhibitor|amod|END_ENTITY	-LSB- Anti-ischemic effect of angiotensin-converting_enzyme inhibitor , but not vitamin_C , in patients with coronary_artery_disease treated with beta-blockers and nitrates .
1720872	0	vitamin_C	37,46	aryl_hydrocarbon_hydroxylase	51,79	vitamin C	aryl hydrocarbon hydroxylase	MESH:D001205	13076(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	In vitro effects of L-ascorbic_acid -LRB- vitamin_C -RRB- on aryl_hydrocarbon_hydroxylase activity in hepatic microsomes of mice .
20693087	0	vitamin_C	11,20	aryl_hydrocarbon_hydroxylase	62,90	vitamin C	aryl hydrocarbon hydroxylase	MESH:D001205	13076(Tax:10090)	Chemical	Gene	metabolites|compound|START_ENTITY metabolites|nmod|inhibition inhibition|nmod|END_ENTITY	Effects of vitamin_C and PCB metabolites on the inhibition of aryl_hydrocarbon_hydroxylase and suppression of mutagenicity of benzo -LSB- a -RSB- pyrene .
22536166	0	vitamin_C	16,25	gulo	53,57	vitamin C	gulo	MESH:D001205	268756(Tax:10090)	Chemical	Gene	concentration|amod|START_ENTITY analysis|nmod|concentration analysis|nmod|organs organs|nmod|mice mice|amod|END_ENTITY	The analysis of vitamin_C concentration in organs of gulo -LRB- - / - -RRB- mice upon vitamin_C withdrawal .
22536166	0	vitamin_C	73,82	gulo	53,57	vitamin C	gulo	MESH:D001205	268756(Tax:10090)	Chemical	Gene	withdrawal|amod|START_ENTITY analysis|nmod|withdrawal analysis|nmod|organs organs|nmod|mice mice|amod|END_ENTITY	The analysis of vitamin_C concentration in organs of gulo -LRB- - / - -RRB- mice upon vitamin_C withdrawal .
23321552	0	vitamin_C	9,18	gulo	61,65	vitamin C	gulo	MESH:D001205	268756(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|motor_defects motor_defects|nmod|mice mice|amod|END_ENTITY	Combined vitamin_C and E deficiency induces motor_defects in gulo -LRB- - / - -RRB- / SVCT2 -LRB- + / - -RRB- mice .
23472641	0	vitamin_C	23,32	gulo	124,128	vitamin C	gulo	MESH:D001205	268756(Tax:10090)	Chemical	Gene	insufficiency|amod|START_ENTITY consequence|nmod|insufficiency ameliorates|nmod|consequence ameliorates|dep|mice mice|amod|acute acute|nmod|END_ENTITY	In vivo consequence of vitamin_C insufficiency in liver_injury : vitamin_C ameliorates T-cell-mediated acute liver_injury in gulo -LRB- - / - -RRB- mice .
23472641	0	vitamin_C	64,73	gulo	124,128	vitamin C	gulo	MESH:D001205	268756(Tax:10090)	Chemical	Gene	ameliorates|amod|START_ENTITY ameliorates|dep|mice mice|amod|acute acute|nmod|END_ENTITY	In vivo consequence of vitamin_C insufficiency in liver_injury : vitamin_C ameliorates T-cell-mediated acute liver_injury in gulo -LRB- - / - -RRB- mice .
10556483	0	vitamin_C	22,31	hSVCT1	47,53	vitamin C	hSVCT1	MESH:D001205	9963	Chemical	Gene	transporter|amod|START_ENTITY transporter|dep|1 1|appos|END_ENTITY	Human Na -LRB- + -RRB- - dependent vitamin_C transporter 1 -LRB- hSVCT1 -RRB- : primary structure , functional characteristics and evidence for a non-functional splice variant .
9280180	0	vitamin_C	43,52	haptoglobin	10,21	vitamin C	haptoglobin	MESH:D001205	3240	Chemical	Gene	metabolism|nmod|START_ENTITY Effect|nmod|metabolism Effect|nmod|END_ENTITY	Effect of haptoglobin on the metabolism of vitamin_C .
16574159	0	vitamin_C	51,60	ornithine_decarboxylase	80,103	vitamin C	ornithine decarboxylase	MESH:D001205	4953	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	The effect of N-acetylcysteine in combination with vitamin_C on the activity of ornithine_decarboxylase of lung_carcinoma cells -- In vitro .
22892142	0	vitamin_C	31,40	p53	45,48	vitamin C	p53	MESH:D001205	7157	Chemical	Gene	activity|nmod|START_ENTITY activity|nmod|END_ENTITY	Enhanced antitumor activity of vitamin_C via p53 in cancer cells .
25586269	0	vitamin_C	80,89	p53	63,66	vitamin C	p53	MESH:D001205	7157	Chemical	Gene	cytotoxicity|amod|START_ENTITY cytotoxicity|nummod|END_ENTITY	SIAH1-induced p34SEI-1 polyubiquitination/degradation mediates p53 preferential vitamin_C cytotoxicity .
18496733	0	vitamin_C	86,95	phospholipase_A2	142,158	vitamin C	phospholipase A2	MESH:D001205	104974671	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Redox-active antioxidant modulation of lipid signaling in vascular endothelial cells : vitamin_C induces activation of phospholipase D through phospholipase_A2 , lipoxygenase , and cyclooxygenase .
11214969	0	vitamin_C	70,79	slc23a1	51,58	vitamin C	slc23a1	MESH:D001205	20522(Tax:10090)	Chemical	Gene	transporter|amod|START_ENTITY encoding|dobj|transporter END_ENTITY|xcomp|encoding	Cloning and genomic organization of the mouse gene slc23a1 encoding a vitamin_C transporter .
22142801	0	vitamin_C	82,91	slc23a1	111,118	vitamin C	slc23a1	MESH:D001205	9963	Chemical	Gene	genes|amod|START_ENTITY characterization|nmod|genes characterization|dep|END_ENTITY	Molecular characterization and transcriptional regulation of the sodium-dependent vitamin_C transporter genes -LRB- slc23a1 and slc23a2 -RRB- in a teleost fish , the Senegalese_sole -LRB- Solea_senegalensis -RRB- .
12149082	4	vitamin_D	533,542	25-hydroxyvitamin_D	567,586	vitamin D	parathyroid hormone	MESH:D014807	5741	Chemical	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	MAIN OUTCOME MEASURES : Bone turnover as measured by urinary deoxypyridinoline -LRB- DPYD -RRB- excretion rates ; and vitamin_D status as determined by 25-hydroxyvitamin_D -LRB- 25OHD -RRB- levels , serum calcium levels and parathyroid_hormone -LRB- PTH -RRB- concentrations .
18689390	4	vitamin_D	817,826	25-hydroxyvitamin_D	911,930	vitamin D	parathyroid hormone	MESH:D014807	5741	Chemical	Gene	biomarkers|amod|START_ENTITY concentration|nsubj|biomarkers concentration|nmod|END_ENTITY	The vitamin_D biomarkers that have shown the most utility to date are the plasma concentration of 25-hydroxyvitamin_D -LRB- supply -RRB- , the plasma concentration of parathyroid_hormone -LRB- function -RRB- , and the presence or absence of rickets -LRB- outcome -RRB- .
19390750	0	vitamin_D	77,86	C-reactive_protein	0,18	vitamin D	C-reactive protein	MESH:D014807	1401	Chemical	Gene	trial|amod|START_ENTITY END_ENTITY|nmod|trial	C-reactive_protein and fibrinogen of bedridden older patients in a six-month vitamin_D supplementation trial .
7594552	0	vitamin_D	38,47	C5a	69,72	vitamin D	C5a	MESH:D014807	728	Chemical	Gene	protein|amod|START_ENTITY effect|appos|protein effect|nmod|END_ENTITY	Co-chemotactic effect of Gc-globulin -LRB- vitamin_D binding protein -RRB- for C5a .
7616106	0	vitamin_D	24,33	C5a	54,57	vitamin D	C5a	MESH:D014807	728	Chemical	Gene	Binding|dep|START_ENTITY Binding|nmod|END_ENTITY	Binding of Gc_globulin -LRB- vitamin_D binding protein -RRB- to C5a or C5a des Arg is not necessary for co-chemotactic activity .
18348265	0	vitamin_D	114,123	COX-2	42,47	vitamin D	COX-2	MESH:D014807	29527(Tax:10116)	Chemical	Gene	analog|amod|START_ENTITY D3|appos|analog inhibition|nmod|D3 inhibition|appos|END_ENTITY	Selective inhibition of cyclooxygenase-2 -LRB- COX-2 -RRB- by 1alpha,25-dihydroxy-16-ene-23-yne-vitamin _ D3 , a less calcemic vitamin_D analog .
12746631	0	vitamin_D	25,34	CYP1alpha	56,65	vitamin D	CYP1alpha	MESH:D014807	1594	Chemical	Gene	study|nmod|START_ENTITY study|dep|gene gene|appos|END_ENTITY	Association study of the vitamin_D : 1alpha-hydroxylase -LRB- CYP1alpha -RRB- gene and type_2_diabetes_mellitus in a Polish population .
12732287	0	vitamin_D	19,28	CYP24	42,47	vitamin D	CYP24	MESH:D014807	1591	Chemical	Gene	START_ENTITY|dobj|expression expression|amod|hydroxylases hydroxylases|dep|END_ENTITY	Genistein inhibits vitamin_D hydroxylases CYP24 and CYP27B1 expression in prostate cells .
14760115	2	vitamin_D	410,419	CYP24	359,364	vitamin D	CYP24	MESH:D014807	1591	Chemical	Gene	mediated|nmod|START_ENTITY control|acl|mediated abrogate|dobj|control leads|xcomp|abrogate leads|nsubj|END_ENTITY	CYP24 leads to abrogate growth control mediated by vitamin_D .
16708384	0	vitamin_D	63,72	CYP24	0,5	vitamin D	CYP24	MESH:D014807	1591	Chemical	Gene	agent|acl|START_ENTITY catabolizes|dobj|agent enzyme|acl:relcl|catabolizes END_ENTITY|appos|enzyme	CYP24 , the enzyme that catabolizes the antiproliferative agent vitamin_D , is increased_in_lung_cancer .
20460683	0	vitamin_D	14,23	CYP24	101,106	vitamin D	CYP24	MESH:D014807	1591	Chemical	Gene	sites|amod|START_ENTITY number|nmod|sites defines|nsubj|number defines|dobj|responsiveness responsiveness|nmod|gene gene|compound|END_ENTITY	The number of vitamin_D receptor binding sites defines the different vitamin_D responsiveness of the CYP24 gene in malignant and normal mammary cells .
20460683	0	vitamin_D	69,78	CYP24	101,106	vitamin D	CYP24	MESH:D014807	1591	Chemical	Gene	responsiveness|amod|START_ENTITY responsiveness|nmod|gene gene|compound|END_ENTITY	The number of vitamin_D receptor binding sites defines the different vitamin_D responsiveness of the CYP24 gene in malignant and normal mammary cells .
21115105	0	vitamin_D	23,32	CYP24	64,69	vitamin D	CYP24	MESH:D014807	1591	Chemical	Gene	START_ENTITY|dobj|induction induction|nmod|END_ENTITY	Valproic_acid augments vitamin_D receptor-mediated induction of CYP24 by vitamin_D3 : a possible cause of valproic_acid-induced osteomalacia ?
8440135	0	vitamin_D	26,35	CYP24	57,62	vitamin D	CYP24	MESH:D014807	1591	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Localization of the human vitamin_D 24-hydroxylase gene -LRB- CYP24 -RRB- to chromosome 20q13 .2 -- > q13 .3 .
9681485	0	vitamin_D	17,26	CYP24	43,48	vitamin D	CYP24	MESH:D014807	25279(Tax:10116)	Chemical	Gene	24-hydroxylase|amod|START_ENTITY 24-hydroxylase|appos|END_ENTITY	Induction of the vitamin_D 24-hydroxylase -LRB- CYP24 -RRB- by 1,25-dihydroxyvitamin _ D3 is regulated by parathyroid hormone in UMR106 osteoblastic cells .
20847308	0	vitamin_D	19,28	CYP24A1	45,52	vitamin D	CYP24A1	MESH:D014807	1591	Chemical	Gene	gene|amod|START_ENTITY Association|nmod|gene END_ENTITY|nsubj|Association	Association of the vitamin_D metabolism gene CYP24A1 with coronary_artery_calcification .
17606874	0	vitamin_D	19,28	CYP27B1	45,52	vitamin D	CYP27B1	MESH:D014807	1594	Chemical	Gene	gene|amod|START_ENTITY Association|nmod|gene END_ENTITY|nsubj|Association	Association of the vitamin_D metabolism gene CYP27B1 with type 1 diabetes .
23965431	0	vitamin_D	21,30	CYP3A4	69,75	vitamin D	CYP3A4	MESH:D014807	1576	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|compound|END_ENTITY	Effects of decreased vitamin_D and accumulated uremic toxin on human CYP3A4 activity in patients with end-stage_renal_disease .
18721734	15	vitamin_D	1631,1640	DBP	1673,1676	vitamin D	DBP	MESH:D014807	1628	Chemical	Gene	intake|amod|START_ENTITY differs|nsubj|intake differs|advcl|polymorphism polymorphism|compound|END_ENTITY	More importantly , vitamin_D intake differs depending on the DBP polymorphism , and is greatest for end-stage_renal_disease patients with a DBP_2-2 phenotype .
19302999	0	vitamin_D	137,146	DBP	58,61	vitamin D	DBP	MESH:D014807	1628	Chemical	Gene	supplementation|amod|START_ENTITY -RSB-|nmod|supplementation D|acl|-RSB- differences|dep|D predict|dobj|differences predict|nsubj|variants variants|nmod|protein protein|appos|END_ENTITY	Common genetic variants of the vitamin_D binding protein -LRB- DBP -RRB- predict differences in response of serum 25-hydroxyvitamin_D -LSB- 25 -LRB- OH -RRB- D -RSB- to vitamin_D supplementation .
19302999	0	vitamin_D	31,40	DBP	58,61	vitamin D	DBP	MESH:D014807	1628	Chemical	Gene	binding|amod|START_ENTITY protein|amod|binding protein|appos|END_ENTITY	Common genetic variants of the vitamin_D binding protein -LRB- DBP -RRB- predict differences in response of serum 25-hydroxyvitamin_D -LSB- 25 -LRB- OH -RRB- D -RSB- to vitamin_D supplementation .
21153172	0	vitamin_D	27,36	DBP	91,94	vitamin D	DBP	MESH:D014807	24309(Tax:10116)	Chemical	Gene	analogues|amod|START_ENTITY studies|nmod|analogues studies|dep|relationship relationship|nmod|vitamin_D_binding_protein vitamin_D_binding_protein|appos|END_ENTITY	Pharmacokinetic studies of vitamin_D analogues : relationship to vitamin_D_binding_protein -LRB- DBP -RRB- .
23857798	0	vitamin_D	42,51	DBP	105,108	vitamin D	DBP	MESH:D014807	1628	Chemical	Gene	activity|nmod|START_ENTITY independent|nsubj|activity independent|nmod|concentrations concentrations|compound|END_ENTITY	In healthy adults , biological activity of vitamin_D , as assessed by serum PTH , is largely independent of DBP concentrations .
25350643	0	vitamin_D	21,30	DBP	48,51	vitamin D	DBP	MESH:D014807	1628	Chemical	Gene	binding|amod|START_ENTITY levels|amod|binding levels|appos|END_ENTITY	The causal effect of vitamin_D binding protein -LRB- DBP -RRB- levels on calcemic and cardiometabolic_diseases : a Mendelian randomization study .
3675739	0	vitamin_D	20,29	DBP	47,50	vitamin D	DBP	MESH:D014807	1628	Chemical	Gene	binding|amod|START_ENTITY protein|amod|binding protein|appos|END_ENTITY	Polymorphism of the vitamin_D binding protein -LRB- DBP -RRB- among primates : an evolutionary analysis .
83206	0	vitamin_D	35,44	DBP	64,67	vitamin D	DBP	MESH:D014807	1628	Chemical	Gene	START_ENTITY|dobj|protein protein|appos|END_ENTITY	-LSB- Isoelectric focusing of the serum vitamin_D transport protein -LRB- DBP -RRB- and the polymorphism of Gc protein .
8370586	0	vitamin_D	25,34	DBP	120,123	vitamin D	DBP	MESH:D014807	1628	Chemical	Gene	metabolites|amod|START_ENTITY differences|nmod|metabolites associated|nsubj|differences associated|nmod|isoforms isoforms|nmod|protein protein|appos|END_ENTITY	Affinity differences for vitamin_D metabolites associated with the genetic isoforms of the human serum carrier protein -LRB- DBP -RRB- .
8381387	0	vitamin_D	96,105	DBP	123,126	vitamin D	DBP	MESH:D014807	1628	Chemical	Gene	binding|amod|START_ENTITY gene|amod|binding gene|appos|END_ENTITY	Molecular evaluation of an Alu repeat including a polymorphic variable poly -LRB- dA -RRB- -LRB- AluVpA -RRB- in the vitamin_D binding protein -LRB- DBP -RRB- gene .
8660573	1	vitamin_D	125,134	DBP	152,155	vitamin D	DBP	MESH:D014807	1628	Chemical	Gene	protein|amod|START_ENTITY protein|dep|known known|advmod|END_ENTITY	Serum vitamin_D binding protein -LRB- DBP , also known as Gc-globulin -RRB- is a multifunctional protein capable of binding both vitamin_D metabolites and actin .
8740896	0	vitamin_D	5,14	DBP	0,3	vitamin D	DBP	MESH:D014807	1628	Chemical	Gene	protein|amod|START_ENTITY END_ENTITY|appos|protein	DBP -LRB- vitamin_D binding protein -RRB- and BF -LRB- properdin_factor_B -RRB- allele distribution in Namibian San and Khoi and in other South African populations .
9916136	1	vitamin_D	120,129	DBP	227,230	vitamin D	DBP	MESH:D014807	13170(Tax:10090)	Chemical	Gene	binding|amod|START_ENTITY protein|amod|binding deficient|nmod|protein line|nmod|deficient generated|nsubjpass|line generated|xcomp|establish establish|dobj|model model|nmod|analysis analysis|nmod|functions functions|nmod:poss|END_ENTITY	A line of mice deficient in vitamin_D binding protein -LRB- DBP -RRB- was generated by targeted mutagenesis to establish a model for analysis of DBP 's biological functions in vitamin_D metabolism and action .
9916136	1	vitamin_D	257,266	DBP	227,230	vitamin D	DBP	MESH:D014807	13170(Tax:10090)	Chemical	Gene	metabolism|amod|START_ENTITY establish|nmod|metabolism establish|dobj|model model|nmod|analysis analysis|nmod|functions functions|nmod:poss|END_ENTITY	A line of mice deficient in vitamin_D binding protein -LRB- DBP -RRB- was generated by targeted mutagenesis to establish a model for analysis of DBP 's biological functions in vitamin_D metabolism and action .
12727200	0	vitamin_D	72,81	DNA-PK	35,41	vitamin D	DNA-PK	MESH:D014807	5591	Chemical	Gene	element|amod|START_ENTITY END_ENTITY|nmod|element	Vitamin_D-dependent recruitment of DNA-PK to the chromatinized negative vitamin_D response element in the PTHrP gene is required for gene repression by vitamin_D .
11082977	0	vitamin_D	103,112	ER	151,153	vitamin D	ER	MESH:D014807	2099	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	-LSB- The influence of hormone replacement therapy -LRB- HRT -RRB- on bone density in menopausal women in relation to vitamin_D receptor -LRB- VDR -RRB- and estrogen_receptor -LRB- ER -RRB- -RSB- .
19965548	0	vitamin_D	46,55	FGF23	59,64	vitamin D	FGF23	MESH:D014807	8074	Chemical	Gene	START_ENTITY|nmod|levels levels|nummod|END_ENTITY	Effects of cinacalcet and concurrent low-dose vitamin_D on FGF23 levels in ESRD .
20732956	0	vitamin_D	11,20	FGF23	50,55	vitamin D	FGF23	MESH:D014807	8074	Chemical	Gene	therapy|amod|START_ENTITY therapy|nmod|concentrations concentrations|compound|END_ENTITY	Effects of vitamin_D replacement therapy on serum FGF23 concentrations in vitamin_D-deficient women in short term .
21730210	9	vitamin_D	1571,1580	FGF23	1490,1495	vitamin D	FGF23	MESH:D014807	8074	Chemical	Gene	effects|nmod|START_ENTITY independently|nmod|effects patients|nmod|independently END_ENTITY|nmod|patients	CONCLUSIONS : Cinacalcet lowers serum FGF23 in haemodialysis patients with SHPT independently of the effects of active vitamin_D .
21932165	0	vitamin_D	12,21	FGF23	29,34	vitamin D	FGF23	MESH:D014807	8074	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of vitamin_D in the FGF23 , klotho , and phosphate bone-kidney_endocrine_axis .
22383345	0	vitamin_D	19,28	FGF23	131,136	vitamin D	FGF23	MESH:D014807	8074	Chemical	Gene	insufficiency|amod|START_ENTITY impact|nmod|insufficiency impact|dep|role role|nmod|END_ENTITY	Distinct impact of vitamin_D insufficiency on calcitriol levels in chronic_renal_failure and renal transplant patients : a role for FGF23 .
22421513	0	vitamin_D	17,26	FGF23	8,13	vitamin D	FGF23	MESH:D014807	8074	Chemical	Gene	metabolism|amod|START_ENTITY END_ENTITY|nmod|metabolism	Role of FGF23 in vitamin_D and phosphate metabolism : implications in chronic_kidney_disease .
23748358	0	vitamin_D	40,49	FGF23	0,5	vitamin D	FGF23	MESH:D014807	8074	Chemical	Gene	relationship|nmod|START_ENTITY modifies|dobj|relationship modifies|nsubj|END_ENTITY	FGF23 modifies the relationship between vitamin_D and cardiac_remodeling .
17646263	0	vitamin_D	88,97	Fgf-23	112,118	vitamin D	Fgf-23	MESH:D014807	64654(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|compound|END_ENTITY	Correlation among hyperphosphatemia , type II sodium_phosphate transporter activity , and vitamin_D metabolism in Fgf-23 null mice .
22606047	0	vitamin_D	81,90	Fibroblast_growth_factor-23	0,27	vitamin D	Fibroblast growth factor-23	MESH:D014807	8074	Chemical	Gene	effects|nmod|START_ENTITY explain|dobj|effects helps|xcomp|explain helps|nsubj|END_ENTITY	Fibroblast_growth_factor-23 helps explain the biphasic cardiovascular effects of vitamin_D in chronic_kidney_disease .
23062388	0	vitamin_D	15,24	Foxp3	30,35	vitamin D	Foxp3	MESH:D014807	50943	Chemical	Gene	START_ENTITY|nmod|induction induction|amod|END_ENTITY	Correlation of vitamin_D with Foxp3 induction and steroid-sparing effect of immunotherapy in asthmatic children .
25147936	0	vitamin_D	44,53	GC_Globulin	71,82	vitamin D	GC Globulin	MESH:D014807	2638	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Possible association between dysfunction of vitamin_D binding protein -LRB- GC_Globulin -RRB- and migraine attacks .
10698343	0	vitamin_D	36,45	Gc-globulin	63,74	vitamin D	Gc-globulin	MESH:D014807	2638	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Neutrophil priming by cytokines and vitamin_D binding protein -LRB- Gc-globulin -RRB- : impact on C5a-mediated chemotaxis , degranulation and respiratory burst .
1643050	0	vitamin_D	66,75	Gc-globulin	93,104	vitamin D	Gc-globulin	MESH:D014807	2638	Chemical	Gene	START_ENTITY|dobj|protein protein|appos|END_ENTITY	Identification of the sterol - and actin-binding domains of plasma vitamin_D binding protein -LRB- Gc-globulin -RRB- .
16697362	0	vitamin_D	39,48	Gc-globulin	66,77	vitamin D	Gc-globulin	MESH:D014807	2638	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Biological and clinical aspects of the vitamin_D binding protein -LRB- Gc-globulin -RRB- and its polymorphism .
18194670	0	vitamin_D	13,22	Gc-globulin	0,11	vitamin D	Gc-globulin	MESH:D014807	2638	Chemical	Gene	protein|amod|START_ENTITY END_ENTITY|appos|protein	Gc-globulin -LRB- vitamin_D binding protein -RRB- is synthesized and secreted by hepatocytes and internalized by hepatic stellate cells through Ca -LRB- 2 + -RRB- - dependent interaction with the megalin/gp330 receptor .
2007578	0	vitamin_D	8,17	Gc-globulin	35,46	vitamin D	Gc-globulin	MESH:D014807	24384(Tax:10116)	Chemical	Gene	START_ENTITY|xcomp|gene gene|nsubj|protein protein|appos|END_ENTITY	The rat vitamin_D binding protein -LRB- Gc-globulin -RRB- gene .
2436858	0	vitamin_D	8,17	Gc-globulin	35,46	vitamin D	Gc-globulin	MESH:D014807	24384(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|protein protein|appos|END_ENTITY	The rat vitamin_D binding protein -LRB- Gc-globulin -RRB- gene is syntenic with the rat albumin and alpha-fetoprotein genes on chromosome 14 .
3015768	0	vitamin_D	43,52	Gc-globulin	70,81	vitamin D	Gc-globulin	MESH:D014807	2638	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Direct regional assignment of the gene for vitamin_D binding protein -LRB- Gc-globulin -RRB- to human chromosome 4q11-q13 and identification of an associated DNA polymorphism .
7594552	0	vitamin_D	38,47	Gc-globulin	25,36	vitamin D	Gc-globulin	MESH:D014807	2638	Chemical	Gene	protein|amod|START_ENTITY effect|appos|protein effect|nmod|END_ENTITY	Co-chemotactic effect of Gc-globulin -LRB- vitamin_D binding protein -RRB- for C5a .
8324227	0	vitamin_D	37,46	Gc-globulin	64,75	vitamin D	Gc-globulin	MESH:D014807	2638	Chemical	Gene	binding|amod|START_ENTITY protein|amod|binding protein|appos|END_ENTITY	Localization and quantitation of the vitamin_D binding protein -LRB- Gc-globulin -RRB- in human neutrophils .
8660573	0	vitamin_D	48,57	Gc-globulin	75,86	vitamin D	Gc-globulin	MESH:D014807	2638	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Electrophoretic mobility shift assay identifies vitamin_D binding protein -LRB- Gc-globulin -RRB- in human , rat , and mouse sera .
20560927	0	vitamin_D	85,94	Gc_globulin	72,83	vitamin D	Gc globulin	MESH:D014807	2638	Chemical	Gene	protein|amod|START_ENTITY END_ENTITY|appos|protein	Safety pharmacology , toxicology and pharmacokinetic assessment of human Gc_globulin -LRB- vitamin_D binding protein -RRB- .
2424747	0	vitamin_D	57,66	Gc_globulin	84,95	vitamin D	Gc globulin	MESH:D014807	14473(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|protein protein|appos|END_ENTITY	Characterization of a monoclonal antibody to human serum vitamin_D binding protein -LRB- Gc_globulin -RRB- : recognition of an epitope hidden in membranes of circulating monocytes .
7616106	0	vitamin_D	24,33	Gc_globulin	11,22	vitamin D	Gc globulin	MESH:D014807	2638	Chemical	Gene	Binding|dep|START_ENTITY Binding|nmod|END_ENTITY	Binding of Gc_globulin -LRB- vitamin_D binding protein -RRB- to C5a or C5a des Arg is not necessary for co-chemotactic activity .
20030662	0	vitamin_D	9,18	ILT3	72,76	vitamin D	ILT3	MESH:D014807	11006	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Maternal vitamin_D intake during pregnancy increases gene expression of ILT3 and ILT4 in cord blood .
24693993	0	vitamin_D	25,34	INS-1	38,43	vitamin D	INS-1	MESH:D014807	2305	Chemical	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Tmem27 is upregulated by vitamin_D in INS-1 cells and its serum concentrations are low in patients with autoimmune diabetes .
15528275	0	vitamin_D	31,40	Insig-2	72,79	vitamin D	Insig-2	MESH:D014807	72999(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|promoter promoter|compound|END_ENTITY	Identification of a functional vitamin_D response element in the murine Insig-2 promoter and its potential role in the differentiation of 3T3-L1 preadipocytes .
24170105	0	vitamin_D	57,66	Insulin	0,7	vitamin D	Insulin	MESH:D014807	3630	Chemical	Gene	concentrations|amod|START_ENTITY associated|nmod|concentrations associated|nsubjpass|indices indices|compound|END_ENTITY	Insulin resistance indices are inversely associated with vitamin_D binding protein concentrations .
24572452	0	vitamin_D	96,105	Insulin	0,7	vitamin D	Insulin	MESH:D014807	3630	Chemical	Gene	analogues|amod|START_ENTITY role|nmod|analogues identifying|dobj|role function|xcomp|identifying function|nsubj|resistance resistance|compound|END_ENTITY	Insulin resistance via modification of PGC1a function identifying a possible preventive role of vitamin_D analogues in chronic inflammatory state of obesity .
26156733	0	vitamin_D	61,70	Insulin	0,7	vitamin D	Insulin	MESH:D014807	3630	Chemical	Gene	adults|nmod|START_ENTITY secretion|nmod|adults secretion|compound|END_ENTITY	Insulin secretion and sensitivity in healthy adults with low vitamin_D are not affected by high-dose ergocalciferol administration : a randomized controlled trial .
19339050	0	vitamin_D	131,140	JNK1	81,85	vitamin D	JNK1	MESH:D014807	5599	Chemical	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	c-Jun_N-terminal_kinase_2 -LRB- JNK2 -RRB- antagonizes the signaling of differentiation by JNK1 in human myeloid_leukemia cells resistant to vitamin_D .
23760318	0	vitamin_D	15,24	LL-37	43,48	vitamin D	LL-37	MESH:D014807	820	Chemical	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Measurement of vitamin_D and cathelicidin -LRB- LL-37 -RRB- levels in patients of psoriasis with co-morbidities .
23320821	0	vitamin_D	25,34	Lipoprotein_lipase	0,18	vitamin D	Lipoprotein lipase	MESH:D014807	4023	Chemical	Gene	links|dobj|START_ENTITY links|nsubj|END_ENTITY	Lipoprotein_lipase links vitamin_D , insulin resistance , and type_2_diabetes : a cross-sectional epidemiological study .
18602086	0	vitamin_D	33,42	MDR1	74,78	vitamin D	MDR1	MESH:D014807	5243	Chemical	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Identification of the functional vitamin_D response elements in the human MDR1 gene .
22328083	0	vitamin_D	26,35	MicroRNA-22	0,11	vitamin D	MicroRNA-22	MESH:D014807	407004	Chemical	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	MicroRNA-22 is induced by vitamin_D and contributes to its antiproliferative , antimigratory and gene regulatory effects in colon_cancer cells .
10681663	0	vitamin_D	78,87	PTH	55,58	vitamin D	PTH	MESH:D014807	5741	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Transcriptional and post-transcriptional regulation of PTH gene expression by vitamin_D , calcium and phosphate .
17560254	0	vitamin_D	5,14	PTH	67,70	vitamin D	PTH	MESH:D014807	5741	Chemical	Gene	supplementation|amod|START_ENTITY reduces|nsubj|supplementation reduces|dobj|incidence incidence|nmod|elevation elevation|compound|END_ENTITY	Oral vitamin_D supplementation reduces the incidence of eucalcemic PTH elevation after surgery for primary_hyperparathyroidism .
17699221	0	vitamin_D	71,80	PTH	109,112	vitamin D	PTH	MESH:D014807	5741	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	Cinacalcet_hydrochloride -LRB- Sensipar -RRB- in hemodialysis patients on active vitamin_D derivatives with controlled PTH and elevated calcium x phosphate .
177292	6	vitamin_D	585,594	PTH	612,615	vitamin D	PTH	MESH:D014807	5741	Chemical	Gene	deficiency|amod|START_ENTITY increase|nmod|deficiency increase|nsubj|levels levels|compound|END_ENTITY	During vitamin_D deficiency , high PTH levels can increase the renal excretion of cyclic_AMP .
19019181	0	vitamin_D	60,69	PTH	44,47	vitamin D	PTH	MESH:D014807	5741	Chemical	Gene	adults|amod|START_ENTITY response|nmod|adults response|compound|END_ENTITY	Factors associated with elevated or blunted PTH response in vitamin_D insufficient adults .
19281737	0	vitamin_D	88,97	PTH	163,166	vitamin D	PTH	MESH:D014807	5741	Chemical	Gene	therapy|amod|START_ENTITY years|nmod|therapy stage|nmod|years CKD|dep|stage African-Americans|nmod|CKD adynamic_bone_disease|nmod|African-Americans Absence|nmod|adynamic_bone_disease Absence|parataxis|truncated truncated|ccomp|fragments fragments|nsubj|END_ENTITY	Absence of adynamic_bone_disease in African-Americans with CKD stage 5 after 3 years of vitamin_D therapy guided by iPTH and the PTH - -LRB- 1-84 -RRB- / N-terminally truncated PTH fragments ratio .
20308769	0	vitamin_D	26,35	PTH	77,80	vitamin D	PTH	MESH:D014807	5741	Chemical	Gene	supplementation|amod|START_ENTITY regimens|nmod|supplementation Impact|nmod|regimens END_ENTITY|nsubj|Impact	Impact of two regimens of vitamin_D supplementation on calcium - vitamin_D - PTH axis of schoolgirls of Delhi .
20308769	0	vitamin_D	65,74	PTH	77,80	vitamin D	PTH	MESH:D014807	5741	Chemical	Gene	Impact|acl|START_ENTITY END_ENTITY|nsubj|Impact	Impact of two regimens of vitamin_D supplementation on calcium - vitamin_D - PTH axis of schoolgirls of Delhi .
20601288	0	vitamin_D	82,91	PTH	14,17	vitamin D	PTH	MESH:D014807	5741	Chemical	Gene	status|amod|START_ENTITY depends|nmod|status depends|nsubj|Regulation Regulation|nmod|secretion secretion|compound|END_ENTITY	Regulation of PTH secretion by 25-hydroxyvitamin_D and ionized calcium depends on vitamin_D status : a study in a large cohort of healthy subjects .
21337382	0	vitamin_D	26,35	PTH	15,18	vitamin D	PTH	MESH:D014807	280903(Tax:9913)	Chemical	Gene	eldecalcitol|amod|START_ENTITY END_ENTITY|nmod|eldecalcitol	Suppression of PTH by the vitamin_D analog eldecalcitol is modulated by its high affinity for the serum vitamin_D-binding protein and resistance to metabolism .
21722152	0	vitamin_D	22,31	PTH	7,10	vitamin D	PTH	MESH:D014807	5741	Chemical	Gene	status|amod|START_ENTITY assessing|dobj|status assessing|nmod|END_ENTITY	Beyond PTH : assessing vitamin_D status during early pregnancy .
21896668	0	vitamin_D	91,100	PTH	0,3	vitamin D	PTH	MESH:D014807	19226(Tax:10090)	Chemical	Gene	suppressing|dobj|START_ENTITY ameliorates|advcl|suppressing ameliorates|nsubj|ablation ablation|compound|END_ENTITY	PTH ablation ameliorates the anomalies of Fgf23-deficient mice by suppressing the elevated vitamin_D and calcium levels .
22179702	0	vitamin_D	73,82	PTH	101,104	vitamin D	PTH	MESH:D014807	5741	Chemical	Gene	gastrectomy|amod|START_ENTITY effects|nmod|gastrectomy effects|appos|END_ENTITY	Mid-term effects of sleeve gastrectomy on calcium metabolism parameters , vitamin_D and parathormone -LRB- PTH -RRB- in morbid obese women .
22972177	0	vitamin_D	147,156	PTH	19,22	vitamin D	PTH	MESH:D014807	5741	Chemical	Gene	deficiency|amod|START_ENTITY incidence|nmod|deficiency shown|dobj|incidence shown|nsubj|END_ENTITY	Normal circulating PTH in Saudi healthy individuals with hypovitaminosis D. Recent studies in the Middle East have shown an increased incidence of vitamin_D deficiency across this region of year-round sunlight .
23857798	0	vitamin_D	42,51	PTH	74,77	vitamin D	PTH	MESH:D014807	5741	Chemical	Gene	activity|nmod|START_ENTITY activity|dep|assessed assessed|nmod|END_ENTITY	In healthy adults , biological activity of vitamin_D , as assessed by serum PTH , is largely independent of DBP concentrations .
24012652	0	vitamin_D	14,23	PTH	56,59	vitamin D	PTH	MESH:D014807	5741	Chemical	Gene	deficiency|amod|START_ENTITY Prevalence|nmod|deficiency Prevalence|nmod|values values|compound|END_ENTITY	Prevalence of vitamin_D deficiency and consequences for PTH reference values .
24305924	0	vitamin_D	104,113	PTH	14,17	vitamin D	PTH	MESH:D014807	5741	Chemical	Gene	deficiency|amod|START_ENTITY thyroidectomy|nmod|deficiency predictor|nmod|thyroidectomy predictor|nsubj|measurement measurement|compound|END_ENTITY	Postoperative PTH measurement is not a reliable predictor for hypocalcemia after total thyroidectomy in vitamin_D deficiency : prospective study of 203 cases .
24712573	0	vitamin_D	64,73	PTH	93,96	vitamin D	PTH	MESH:D014807	5741	Chemical	Gene	repletion|amod|START_ENTITY repletion|nmod|END_ENTITY	Vitamin_D-binding_protein levels do not influence the effect of vitamin_D repletion on serum PTH and calcium : data from a randomized , controlled trial .
25366373	0	vitamin_D	109,118	PTH	160,163	vitamin D	PTH	MESH:D014807	5741	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	Associations between the levels of sclerostin , phosphate , and fibroblast_growth_factor-23 and treatment with vitamin_D in hemodialysis patients with low intact PTH level .
27057941	0	vitamin_D	17,26	PTH	27,30	vitamin D	PTH	MESH:D014807	5741	Chemical	Gene	axis|amod|START_ENTITY axis|compound|END_ENTITY	Soluble ST2 , the vitamin_D / PTH axis and the heart : New interactions in the air ?
2788385	0	vitamin_D	83,92	PTH	10,13	vitamin D	PTH	MESH:D014807	5741	Chemical	Gene	deficiency|amod|START_ENTITY homeostasis|nmod|deficiency indicator|nmod|homeostasis indicator|nsubj|END_ENTITY	Is intact PTH a sensitive biochemical indicator of deranged calcium homeostasis in vitamin_D deficiency ?
2988344	0	vitamin_D	45,54	PTH	34,37	vitamin D	PTH	MESH:D014807	5741	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects and interrelationships of PTH , Ca2 + , vitamin_D , and Pi in acid-base homeostasis .
6086295	0	vitamin_D	29,38	PTH	55,58	vitamin D	PTH	MESH:D014807	24694(Tax:10116)	Chemical	Gene	preparations|amod|START_ENTITY preparations|nmod|END_ENTITY	Inhibitory effects of active vitamin_D preparations on PTH secretion in rats .
6791781	0	vitamin_D	10,19	PTH	35,38	vitamin D	PTH	MESH:D014807	5741	Chemical	Gene	metabolites|amod|START_ENTITY metabolites|nmod|END_ENTITY	Action of vitamin_D metabolites on PTH secretion in man .
7353372	0	vitamin_D	3,12	PTH	63,66	vitamin D	PTH	MESH:D014807	5741	Chemical	Gene	affect|nsubj|START_ENTITY affect|dobj|release release|nmod|END_ENTITY	Do vitamin_D or its metabolites directly affect the release of PTH ?
8862484	0	vitamin_D	66,75	PTH	6,9	vitamin D	PTH	MESH:D014807	5741	Chemical	Gene	status|amod|START_ENTITY load|nmod|status END_ENTITY|nmod|load	Acute PTH response to oral calcium load and seasonal variation of vitamin_D status in healthy young adult subjects .
9717845	0	vitamin_D	22,31	PTH	48,51	vitamin D	PTH	MESH:D014807	24694(Tax:10116)	Chemical	Gene	action|nmod:poss|START_ENTITY action|nmod|gene gene|compound|END_ENTITY	Calreticulin inhibits vitamin_D 's action on the PTH gene in vitro and may prevent vitamin_D 's effect in vivo in hypocalcemic rats .
15225805	0	vitamin_D	44,53	PTH-1R	0,6	vitamin D	PTH-1R	MESH:D014807	56813(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|responses responses|compound|END_ENTITY	PTH-1R responses to PTHrP and regulation by vitamin_D in keratinocytes and adjacent fibroblasts .
11997185	0	vitamin_D	53,62	PTH-related_protein	14,33	vitamin D	PTH-related protein	MESH:D014807	5744	Chemical	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of PTH-related_protein gene expression by vitamin_D in PC-3_prostate_cancer cells .
12727200	0	vitamin_D	72,81	PTHrP	106,111	vitamin D	PTHrP	MESH:D014807	5744	Chemical	Gene	element|amod|START_ENTITY element|nmod|gene gene|compound|END_ENTITY	Vitamin_D-dependent recruitment of DNA-PK to the chromatinized negative vitamin_D response element in the PTHrP gene is required for gene repression by vitamin_D .
217686	0	vitamin_D	45,54	Parathyroid_hormone	0,19	vitamin D	Parathyroid hormone	MESH:D014807	5741	Chemical	Gene	deficient|amod|START_ENTITY levels|nmod|deficient levels|compound|END_ENTITY	Parathyroid_hormone and calcitonin levels in vitamin_D deficient rickets .
22849753	0	vitamin_D	105,114	Parathyroid_hormone	0,19	vitamin D	Parathyroid hormone	MESH:D014807	5741	Chemical	Gene	status|amod|START_ENTITY independent|nmod|status biomarkers|appos|independent associated|nmod|biomarkers associated|nsubjpass|END_ENTITY	Parathyroid_hormone is associated with biomarkers of insulin resistance and inflammation , independent of vitamin_D status , in obese adolescents .
23679090	0	vitamin_D	21,30	Parathyroid_hormone	0,19	vitamin D	Parathyroid hormone	MESH:D014807	5741	Chemical	Gene	levels|amod|START_ENTITY excretion|nsubj|levels excretion|advmod|END_ENTITY	Parathyroid_hormone , vitamin_D levels and urine albumin excretion in older persons : the 2011 Korea National Health and Nutrition Examination Survey -LRB- KNHANES -RRB- .
8756542	0	vitamin_D	119,128	Parathyroid_hormone	0,19	vitamin D	Parathyroid hormone	MESH:D014807	280903(Tax:9913)	Chemical	Gene	metabolites|amod|START_ENTITY stimulates|nmod|metabolites stimulates|nsubj|END_ENTITY	Parathyroid_hormone rapidly stimulates phosphate transport in perfused duodenal loops of chicks : lack of modulation by vitamin_D metabolites .
16849588	0	vitamin_D	37,46	Prohibitin	0,10	vitamin D	Prohibitin	MESH:D014807	5245	Chemical	Gene	gene|nmod|START_ENTITY gene|nsubj|END_ENTITY	Prohibitin is a novel target gene of vitamin_D involved in its antiproliferative action in breast_cancer cells .
16741990	0	vitamin_D	74,83	Prostate_derived_factor	0,23	vitamin D	Prostate derived factor	MESH:D014807	64146	Chemical	Gene	induction|nmod|START_ENTITY END_ENTITY|dep|induction	Prostate_derived_factor in human prostate_cancer cells : gene induction by vitamin_D via a p53-dependent mechanism and inhibition of prostate_cancer cell growth .
21169421	0	vitamin_D	49,58	Pth	22,25	vitamin D	Pth	MESH:D014807	19226(Tax:10090)	Chemical	Gene	prohormones|amod|START_ENTITY expression|nmod|prohormones expression|compound|END_ENTITY	Direct suppression of Pth gene expression by the vitamin_D prohormones doxercalciferol and calcidiol requires the vitamin_D_receptor .
21735060	0	vitamin_D	59,68	SGLT1	41,46	vitamin D	SGLT1	MESH:D014807	20537(Tax:10090)	Chemical	Gene	stimulation|nmod|START_ENTITY stimulation|nmod|activity activity|compound|END_ENTITY	SGK1-dependent stimulation of intestinal SGLT1 activity by vitamin_D .
23530237	0	vitamin_D	24,33	Sclerostin	0,10	vitamin D	Sclerostin	MESH:D014807	74499(Tax:10090)	Chemical	Gene	metabolite|amod|START_ENTITY alters|dobj|metabolite alters|nsubj|END_ENTITY	Sclerostin alters serum vitamin_D metabolite and fibroblast_growth_factor_23 concentrations and the urinary excretion of calcium .
22851187	0	vitamin_D	14,23	TGF_b1	41,47	vitamin D	TGF b1	MESH:D014807	59086(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of vitamin_D on expression of TGF_b1 in ovary .
18080320	0	vitamin_D	114,123	TNF	31,34	vitamin D	TNF	MESH:D014807	7124	Chemical	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Two modes of ERK activation by TNF in keratinocytes : different cellular outcomes and bi-directional modulation by vitamin_D .
10510471	0	vitamin_D	16,25	TNFalpha	37,45	vitamin D	TNFalpha	MESH:D014807	7124	Chemical	Gene	analogs|amod|START_ENTITY analogs|nmod|END_ENTITY	Potentiation by vitamin_D analogs of TNFalpha and ceramide-induced apoptosis in MCF-7 cells is associated with activation of cytosolic_phospholipase_A2 .
19779013	0	vitamin_D	28,37	TRPV6	53,58	vitamin D	TRPV6	MESH:D014807	55503	Chemical	Gene	metabolites|amod|START_ENTITY metabolites|nmod|END_ENTITY	Human duodenum responses to vitamin_D metabolites of TRPV6 and other genes involved in calcium absorption .
24693993	0	vitamin_D	25,34	Tmem27	0,6	vitamin D	Tmem27	MESH:D014807	57393	Chemical	Gene	upregulated|nmod|START_ENTITY upregulated|nsubjpass|END_ENTITY	Tmem27 is upregulated by vitamin_D in INS-1 cells and its serum concentrations are low in patients with autoimmune diabetes .
21684333	0	vitamin_D	15,24	VDBP	42,46	vitamin D	VDBP	MESH:D014807	2638	Chemical	Gene	binding|amod|START_ENTITY polymorphisms|amod|binding polymorphisms|appos|END_ENTITY	Association of vitamin_D binding protein -LRB- VDBP -RRB- polymorphisms and serum 25 -LRB- OH -RRB- D concentrations in a sample of young Canadian adults of different ancestry .
22871339	0	vitamin_D	15,24	VDBP	46,50	vitamin D	VDBP	MESH:D014807	2638	Chemical	Gene	components|amod|START_ENTITY Expressions|nmod|components END_ENTITY|nsubj|Expressions	Expressions of vitamin_D metabolic components VDBP , CYP2R1 , CYP27B1 , CYP24A1 , and VDR in placentas from normal and preeclamptic pregnancies .
26778482	0	vitamin_D	61,70	VDBP	88,92	vitamin D	VDBP	MESH:D014807	24384(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|protein protein|appos|END_ENTITY	L-cysteine supplementation upregulates glutathione -LRB- GSH -RRB- and vitamin_D binding protein -LRB- VDBP -RRB- in hepatocytes cultured in high glucose and in vivo in liver , and increases blood levels of GSH , VDBP , and 25-hydroxy-vitamin_D in Zucker_diabetic_fatty_rats .
10404016	0	vitamin_D	10,19	VDR	35,38	vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The human vitamin_D receptor gene -LRB- VDR -RRB- is localized to region 12cen-q12 by fluorescent in situ hybridization and radiation hybrid mapping : genetic and physical VDR map .
11082977	0	vitamin_D	103,112	VDR	123,126	vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	-LSB- The influence of hormone replacement therapy -LRB- HRT -RRB- on bone density in menopausal women in relation to vitamin_D receptor -LRB- VDR -RRB- and estrogen_receptor -LRB- ER -RRB- -RSB- .
11250942	0	vitamin_D	117,126	VDR	137,140	vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Glucocorticoid receptor-interacting protein-1 and receptor-associated coactivator-3 differentially interact with the vitamin_D receptor -LRB- VDR -RRB- and regulate VDR-retinoid X receptor transcriptional cross-talk .
12086963	0	vitamin_D	68,77	VDR	34,37	vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	status|amod|START_ENTITY relation|nmod|status levels|nmod|relation levels|compound|END_ENTITY	Vitamin_D_receptor -LRB- VDR -RRB- mRNA and VDR protein levels in relation to vitamin_D status , insulin secretory capacity , and VDR genotype in Bangladeshi Asians .
12470639	0	vitamin_D	87,96	VDR	9,12	vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	induces|ccomp|START_ENTITY induces|nsubj|END_ENTITY	Liganded VDR induces CYP3A4 in small intestinal and colon_cancer cells via DR3 and ER6 vitamin_D responsive elements .
12816431	0	vitamin_D	101,110	VDR	121,124	vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Functionalization at C-12 of 1alpha,25-dihydroxyvitamin _ D -LRB- 3 -RRB- strongly modulates the affinity for the vitamin_D receptor -LRB- VDR -RRB- .
14727381	0	vitamin_D	39,48	VDR	59,62	vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Analysis of Bsm I polymorphism of the vitamin_D receptor -LRB- VDR -RRB- gene in Venezuelan female patients living in the state of Zulia with osteoporosis -RSB- .
15252846	0	vitamin_D	17,26	VDR	28,31	vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	calcium|acl|START_ENTITY END_ENTITY|nsubj|calcium	Dietary calcium , vitamin_D , VDR genotypes and colorectal_cancer .
15876428	0	vitamin_D	40,49	VDR	108,111	vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	action|amod|START_ENTITY modulates|dobj|action modulates|nmod|expression expression|nmod|END_ENTITY	Lipopolysaccharide negatively modulates vitamin_D action by down-regulating expression of vitamin_D-induced VDR in human monocytic THP-1 cells .
17236578	0	vitamin_D	54,63	VDR	74,77	vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	-LSB- Study on the association of two polymorphisms of the vitamin_D receptor -LRB- VDR -RRB- gene with the susceptibility to pulmonary_tuberculosis -LRB- PTB -RRB- in Chinese Tibetans -RSB- .
17264402	0	vitamin_D	47,56	VDR	67,70	vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	BsmI , TaqI , ApaI and FokI polymorphisms in the vitamin_D receptor -LRB- VDR -RRB- gene and the risk of osteoporosis : a meta-analysis .
17507731	2	vitamin_D	237,246	VDR	306,309	vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	roles|nmod|START_ENTITY suggested|nsubjpass|roles suggested|nmod|discovery discovery|nmod|receptor receptor|appos|END_ENTITY	More extensive roles for vitamin_D were suggested by the discovery of the vitamin_D receptor -LRB- VDR -RRB- in tissues that are not involved in calcium and phosphate metabolism .
17507731	2	vitamin_D	286,295	VDR	306,309	vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	More extensive roles for vitamin_D were suggested by the discovery of the vitamin_D receptor -LRB- VDR -RRB- in tissues that are not involved in calcium and phosphate metabolism .
17716971	9	vitamin_D	1209,1218	VDR	1181,1184	vitamin D	p73	MESH:D014807	7161	Chemical	Gene	treatment|amod|START_ENTITY sensitizes|nmod|treatment sensitizes|nsubj|induction induction|nmod|END_ENTITY	Finally , we show that upon DNA damage , induction of VDR sensitizes the cells to vitamin_D treatment .
17822494	1	vitamin_D	125,134	VDR	145,148	vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	BACKGROUND : It has been demonstrated that the vitamin_D receptor -LRB- VDR -RRB- is strongly expressed in key structures of hair follicles , and a lack of VDR leads to alopecia .
18278558	0	vitamin_D	25,34	VDR	45,48	vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	receptor|amod|START_ENTITY polymorphisms|nmod|receptor polymorphisms|appos|END_ENTITY	Genetic polymorphisms of vitamin_D receptor -LRB- VDR -RRB- in Fabry_disease .
18644400	0	vitamin_D	20,29	VDR	67,70	vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	START_ENTITY|ccomp|induce induce|dobj|accumulation accumulation|nmod|END_ENTITY	Side-chain modified vitamin_D analogs induce rapid accumulation of VDR in the cell nuclei proportionately to their differentiation-inducing potential .
18709640	0	vitamin_D	56,65	VDR	189,192	vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	intake|amod|START_ENTITY association|nmod|intake Modification|nmod|association supports|nsubj|Modification supports|dobj|action action|nmod|intake intake|acl|mediated mediated|nmod|binding binding|compound|END_ENTITY	Modification of the inverse association between dietary vitamin_D intake and colorectal_cancer risk by a FokI variant supports a chemoprotective action of Vitamin_D intake mediated through VDR binding .
20432164	0	vitamin_D	9,18	VDR	20,23	vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	genotypes|advmod|START_ENTITY genotypes|nsubj|END_ENTITY	Calcium , vitamin_D , VDR genotypes , and epigenetic and genetic changes in rectal_tumors .
20601302	0	vitamin_D	47,56	VDR	67,70	vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	BsmI , TaqI , ApaI and FokI polymorphisms in the vitamin_D receptor -LRB- VDR -RRB- gene and risk of fracture in Caucasians : a meta-analysis .
21133615	0	vitamin_D	39,48	VDR	59,62	vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of genetic variants of the vitamin_D receptor -LRB- VDR -RRB- gene -LRB- Fok-I , Taq-I and Bsm-I -RRB- with susceptibility of benign_prostatic_hyperplasia in a North Indian population .
22345993	0	vitamin_D	39,48	VDR	59,62	vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Risk conferred by FokI polymorphism of vitamin_D receptor -LRB- VDR -RRB- gene for essential hypertension .
22540341	0	vitamin_D	47,56	VDR	67,70	vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	ApaI , BsmI , FokI and TaqI polymorphisms in the vitamin_D receptor -LRB- VDR -RRB- gene and the risk of psoriasis : a meta-analysis .
22564762	3	vitamin_D	633,642	VDR	653,656	vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	We report that PIAS4 represents a direct binding partner for vitamin_D receptor -LRB- VDR -RRB- and also facilitates its modification with SUMO2 , a process that preferentially occurs on the apo-form of VDR and which is reversed upon binding of ligand .
23022574	0	vitamin_D	29,38	VDR	126,129	vitamin D	VDR	MESH:D014807	22337(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY balance|nmod|homeostasis balance|dep|lessons lessons|acl|learned learned|nmod|mice mice|amod|END_ENTITY	The delicate balance between vitamin_D , calcium and bone homeostasis : lessons learned from intestinal - and osteocyte-specific VDR null mice .
23453529	0	vitamin_D	8,17	VDR	28,31	vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	receptor|amod|START_ENTITY Role|nmod|receptor Role|appos|END_ENTITY	Role of vitamin_D receptor -LRB- VDR -RRB- polymorphisms in susceptibility to multiple_myeloma in ethnic Kashmiri population .
23500379	0	vitamin_D	21,30	VDR	46,49	vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Relationship between vitamin_D receptor gene -LRB- VDR -RRB- polymorphisms , vitamin_D status , osteoarthritis and intervertebral_disc_degeneration .
23500379	0	vitamin_D	66,75	VDR	46,49	vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	START_ENTITY|ccomp|polymorphisms polymorphisms|nsubj|Relationship Relationship|nmod|gene gene|appos|END_ENTITY	Relationship between vitamin_D receptor gene -LRB- VDR -RRB- polymorphisms , vitamin_D status , osteoarthritis and intervertebral_disc_degeneration .
23681781	0	vitamin_D	70,79	VDR	27,30	vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Stable expression of human VDR in murine VDR-null cells recapitulates vitamin_D mediated anti-cancer signaling .
23806555	0	vitamin_D	68,77	VDR	88,91	vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Development of stapled short helical peptides capable of inhibiting vitamin_D receptor -LRB- VDR -RRB- - coactivator interactions .
23826116	0	vitamin_D	21,30	VDR	41,44	vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	Receptor|amod|START_ENTITY Receptor|appos|END_ENTITY	Polymorphisms in the vitamin_D Receptor -LRB- VDR -RRB- and the risk of ovarian_cancer : a meta-analysis .
24200978	0	vitamin_D	18,27	VDR	50,53	vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	status|amod|START_ENTITY status|nmod|relation relation|nmod|END_ENTITY	Serum 25 -LRB- OH -RRB- D and vitamin_D status in relation to VDR , GC and CYP2R1 variants in Chinese .
24228495	0	vitamin_D	14,23	VDR	34,37	vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Evaluation of vitamin_D receptor -LRB- VDR -RRB- gene polymorphisms -LRB- FokI , TaqI and ApaI -RRB- in a family with dentinogenesis_imperfecta .
24558197	0	vitamin_D	69,78	VDR	30,33	vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	status|amod|START_ENTITY neonatal|dobj|status related|xcomp|neonatal related|nsubjpass|vitamin_D_receptor vitamin_D_receptor|appos|END_ENTITY	Placental vitamin_D_receptor -LRB- VDR -RRB- expression is related to neonatal vitamin_D status , placental calcium transfer , and fetal bone length in pregnant adolescents .
24771013	0	vitamin_D	21,30	VDR	41,44	vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Polymorphisms in the vitamin_D receptor -LRB- VDR -RRB- genes and skin_cancer risk in European population : a meta-analysis .
24810167	0	vitamin_D	25,34	VDR	50,53	vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	FokI Polymorphism in the vitamin_D receptor gene -LRB- VDR -RRB- and its association with lumbar spine pathologies in the italian population : a case-control study .
25576905	0	vitamin_D	82,91	VDR	0,3	vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	stimulation|amod|START_ENTITY population|nmod|stimulation associated|nmod|population associated|nsubjpass|polymorphism polymorphism|compound|END_ENTITY	VDR FokI polymorphism is associated with a reduced T-helper cell population under vitamin_D stimulation in type 1 diabetes patients .
25595352	0	vitamin_D	20,29	VDR	131,134	vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	concentration|amod|START_ENTITY concentration|nmod|hormones hormones|nmod|population population|nmod|genotypes genotypes|nmod|END_ENTITY	Association between vitamin_D concentration and levels of sex hormones in an elderly Polish population with different genotypes of VDR polymorphisms -LRB- rs10735810 , rs1544410 , rs7975232 , rs731236 -RRB- .
25637122	0	vitamin_D	60,69	VDR	80,83	vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Structural development of stapled short helical peptides as vitamin_D receptor -LRB- VDR -RRB- - coactivator interaction inhibitors .
25827670	0	vitamin_D	159,168	VDR	79,82	vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	insufficiency|amod|START_ENTITY women|nmod|insufficiency profile|nmod|women gene|nmod|profile gene|compound|END_ENTITY	Effect of vitamin_D3 supplementation and influence of BsmI polymorphism of the VDR gene of the inflammatory profile and oxidative stress in elderly women with vitamin_D insufficiency : Vitamin_D3 megadose reduces inflammatory markers .
25938686	0	vitamin_D	27,36	VDR	87,90	vitamin D	VDR	MESH:D014807	22337(Tax:10090)	Chemical	Gene	functions|nmod|START_ENTITY functions|acl:relcl|learned learned|nmod|studies studies|compound|END_ENTITY	Physiological functions of vitamin_D : what we have learned from global and conditional VDR knockout mouse studies .
26104127	0	vitamin_D	65,74	VDR	85,88	vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Relationship between preeclampsia , gestational hypertension , and vitamin_D receptor -LRB- VDR -RRB- gene polymorphisms .
26104128	0	vitamin_D	78,87	VDR	98,101	vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Response to : Relationship between preeclampsia , gestational hypertension , and vitamin_D receptor -LRB- VDR -RRB- gene polymorphisms .
26415498	0	vitamin_D	25,34	VDR	45,48	vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Replication study of the vitamin_D receptor -LRB- VDR -RRB- genotype association with skeletal muscle traits and sarcopenia .
26432035	0	vitamin_D	60,69	VDR	80,83	vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Effects of alkyl side chains and terminal hydrophilicity on vitamin_D receptor -LRB- VDR -RRB- agonistic activity based on the diphenylpentane skeleton .
26436404	0	vitamin_D	57,66	VDR	77,80	vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Analysis of the association between polymorphisms in the vitamin_D receptor -LRB- VDR -RRB- gene and dental_caries in a Chinese population .
26881316	0	vitamin_D	45,54	VDR	100,103	vitamin D	VDR	MESH:D014807	7421	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Independent associations of polymorphisms in vitamin_D binding protein -LRB- GC -RRB- and vitamin_D_receptor -LRB- VDR -RRB- genes with obesity and plasma 25OHD3 levels demonstrate sex dimorphism .
9541257	0	vitamin_D	60,69	VDR	40,43	vitamin D	VDR	MESH:D014807	24873(Tax:10116)	Chemical	Gene	element|amod|START_ENTITY binding|nmod|element vitamin_D3_receptor|amod|binding vitamin_D3_receptor|appos|END_ENTITY	Characteristics of vitamin_D3_receptor -LRB- VDR -RRB- binding to the vitamin_D response element -LRB- VDRE -RRB- in rat bone_sialoprotein gene promoter .
26547217	0	vitamin_D	35,44	Vitamin_D-binding_protein	0,25	vitamin D	Vitamin D-binding protein	MESH:D014807	2638	Chemical	Gene	concentrations|compound|START_ENTITY concentrations|amod|END_ENTITY	Vitamin_D-binding_protein and free vitamin_D concentrations in acromegaly .
10571682	0	vitamin_D	112,121	Vitamin_D_receptor	0,18	vitamin D	Vitamin D receptor	MESH:D014807	24873(Tax:10116)	Chemical	Gene	elements|amod|START_ENTITY effects|nmod|elements interactions|dep|effects interactions|amod|END_ENTITY	Vitamin_D_receptor interactions with the rat parathyroid_hormone gene : synergistic effects between two negative vitamin_D response elements .
11489753	0	vitamin_D	106,115	Vitamin_D_receptor	0,18	vitamin D	Vitamin D receptor	MESH:D014807	7421	Chemical	Gene	interaction|nmod|START_ENTITY evidence|nmod|interaction polymorphism|dep|evidence polymorphism|compound|END_ENTITY	Vitamin_D_receptor polymorphism and the risk of colorectal_adenomas : evidence of interaction with dietary vitamin_D and calcium .
12753256	0	vitamin_D	35,44	Vitamin_D_receptor	0,18	vitamin D	Vitamin D receptor	MESH:D014807	7421	Chemical	Gene	resistance|amod|START_ENTITY mechanisms|nmod|resistance END_ENTITY|dep|mechanisms	Vitamin_D_receptor : mechanisms for vitamin_D resistance in renal_failure .
17551468	0	vitamin_D	66,75	Vitamin_D_receptor	0,18	vitamin D	Vitamin D receptor	MESH:D014807	7421	Chemical	Gene	story|acl|START_ENTITY defects|dep|story defects|amod|END_ENTITY	Vitamin_D_receptor defects : the story of hereditary resistance to vitamin_D .
18365588	0	vitamin_D	63,72	Vitamin_D_receptor	0,18	vitamin D	Vitamin D receptor	MESH:D014807	7421	Chemical	Gene	deficient_rickets|amod|START_ENTITY polymorphisms|nmod|deficient_rickets polymorphisms|nsubj|gene gene|amod|END_ENTITY	Vitamin_D_receptor gene polymorphisms in Turkish children with vitamin_D deficient_rickets .
19647104	0	vitamin_D	72,81	Vitamin_D_receptor	0,18	vitamin D	Vitamin D receptor	MESH:D014807	7421	Chemical	Gene	supplementation|amod|START_ENTITY modulate|nmod|supplementation modulate|nsubj|polymorphisms polymorphisms|amod|END_ENTITY	Vitamin_D_receptor gene polymorphisms modulate the skeletal response to vitamin_D supplementation in healthy girls .
8833658	0	vitamin_D	69,78	Vitamin_D_receptor	0,18	vitamin D	Vitamin D receptor	MESH:D014807	7421	Chemical	Gene	START_ENTITY|nsubj|binding binding|compound|END_ENTITY	Vitamin_D_receptor binding to the negative human parathyroid hormone vitamin_D response element does not require the retinoid_x_receptor .
9027366	0	vitamin_D	106,115	Vitamin_D_receptor	0,18	vitamin D	Vitamin D receptor	MESH:D014807	7421	Chemical	Gene	lines|amod|START_ENTITY effects|nmod|lines predict|dobj|effects predict|nsubj|content content|amod|END_ENTITY	Vitamin_D_receptor content and transcriptional activity do not fully predict antiproliferative effects of vitamin_D in human prostate_cancer cell lines .
9610787	0	vitamin_D	46,55	Vitamin_D_receptor	0,18	vitamin D	Vitamin D receptor	MESH:D014807	7421	Chemical	Gene	metabolites|amod|START_ENTITY circulating|dobj|metabolites polymorphisms|xcomp|circulating polymorphisms|nsubj|END_ENTITY	Vitamin_D_receptor polymorphisms , circulating vitamin_D metabolites , and risk of prostate_cancer in United States physicians .
21274306	0	vitamin_D	14,23	adiponectin	43,54	vitamin D	adiponectin	MESH:D014807	9370	Chemical	Gene	treatment|amod|START_ENTITY effect|nmod|treatment effect|nmod|levels levels|compound|END_ENTITY	The effect of vitamin_D treatment on serum adiponectin levels in children with vitamin_D_deficiency_rickets .
24039193	0	vitamin_D	85,94	cathelicidin_antimicrobial_peptide	31,65	vitamin D	cathelicidin antimicrobial peptide	MESH:D014807	820	Chemical	Gene	induction|nmod|START_ENTITY induction|nmod|expression expression|compound|END_ENTITY	Synergistic induction of human cathelicidin_antimicrobial_peptide gene expression by vitamin_D and stilbenoids .
23705925	0	vitamin_D	131,140	fibroblast_growth_factor-23	29,56	vitamin D	fibroblast growth factor-23	MESH:D014807	8074	Chemical	Gene	patients|amod|START_ENTITY Ca|nmod|patients independent|nmod|Ca independent|nsubj|lowering lowering|nmod|concentration concentration|amod|END_ENTITY	Cinacalcet lowering of serum fibroblast_growth_factor-23 concentration may be independent from serum Ca , P , PTH and dose of active vitamin_D in peritoneal_dialysis patients : a randomized controlled study .
24748388	0	vitamin_D	19,28	fibroblast_growth_factor-23	38,65	vitamin D	fibroblast growth factor-23	MESH:D014807	8074	Chemical	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Coexistence of low vitamin_D and high fibroblast_growth_factor-23 plasma levels predicts an adverse outcome in patients with coronary_artery_disease .
2897057	0	vitamin_D	10,19	gastrin	23,30	vitamin D	gastrin	MESH:D014807	25320(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Effect of vitamin_D on gastrin and gastric somatostatin secretion from the isolated perfused rat stomach .
26067474	0	vitamin_D	15,24	gc_globulin	112,123	vitamin D	gc globulin	MESH:D014807	2638	Chemical	Gene	polymorphisms|amod|START_ENTITY Association|nmod|polymorphisms Association|dep|study study|nmod|END_ENTITY	Association of vitamin_D binding protein polymorphisms with bronchopulmonary_dysplasia : a case-control study of gc_globulin and bronchopulmonary_dysplasia .
8897577	0	vitamin_D	52,61	growth_hormone	10,24	vitamin D	growth hormone	MESH:D014807	2688	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of growth_hormone on urine calcium and serum vitamin_D metabolites in renal_failure .
11231880	0	vitamin_D	4,13	insulin	93,100	vitamin D	insulin	MESH:D014807	3630	Chemical	Gene	polymorphism|amod|START_ENTITY factor|nsubj|polymorphism factor|nmod|resistance resistance|compound|END_ENTITY	The vitamin_D receptor polymorphism in the translation initiation codon is a risk factor for insulin resistance in glucose_tolerant_Caucasians .
14608076	0	vitamin_D	130,139	insulin	48,55	vitamin D	insulin	MESH:D014807	396145(Tax:9031)	Chemical	Gene	status|compound|START_ENTITY regardless|nmod|status rats|advmod|regardless concentrations|nmod|rats concentrations|amod|pancreatic pancreatic|nmod|release release|compound|END_ENTITY	Dietary boron decreases peak pancreatic in situ insulin release in chicks and plasma insulin concentrations in rats regardless of vitamin_D or magnesium status .
19515534	0	vitamin_D	103,112	insulin	61,68	vitamin D	insulin	MESH:D014807	3630	Chemical	Gene	insufficiency|amod|START_ENTITY individuals|nmod|insufficiency resistance|nmod|individuals resistance|compound|END_ENTITY	Moderate alcohol_intake is associated with decreased risk of insulin resistance among individuals with vitamin_D insufficiency .
20215450	0	vitamin_D	15,24	insulin	30,37	vitamin D	insulin	MESH:D014807	3630	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	Association of vitamin_D with insulin resistance and beta-cell dysfunction in subjects at risk for type 2 diabetes .
21273498	0	vitamin_D	39,48	insulin	71,78	vitamin D	insulin	MESH:D014807	3630	Chemical	Gene	concentrations|nmod|START_ENTITY Associations|nmod|concentrations Associations|nmod|END_ENTITY	Associations between concentrations of vitamin_D and concentrations of insulin , glucose , and HbA1c among adolescents in the United States .
21871642	0	vitamin_D	93,102	insulin	58,65	vitamin D	insulin	MESH:D014807	3630	Chemical	Gene	polymorphisms|xcomp|START_ENTITY polymorphisms|nmod|resistance resistance|compound|END_ENTITY	Association of vitamin_D_receptor gene polymorphisms with insulin resistance and response to vitamin_D .
22562539	0	vitamin_D	38,47	insulin	18,25	vitamin D	insulin	MESH:D014807	3630	Chemical	Gene	START_ENTITY|nsubj|Hyperinsulinemia Hyperinsulinemia|appos|resistance resistance|compound|END_ENTITY	Hyperinsulinemia , insulin resistance , vitamin_D , and colorectal_cancer among whites and African Americans .
22744624	0	vitamin_D	11,20	insulin	24,31	vitamin D	insulin	MESH:D014807	3630	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	Effects of vitamin_D on insulin resistance in nursing home residents : an interventional study .
23111651	0	vitamin_D	10,19	insulin	35,42	vitamin D	insulin	MESH:D014807	3630	Chemical	Gene	replacement|amod|START_ENTITY Effect|nmod|replacement Effect|nmod|sensitivity sensitivity|compound|END_ENTITY	Effect of vitamin_D replacement on insulin sensitivity in subjects with vitamin_D deficiency .
23111651	0	vitamin_D	72,81	insulin	35,42	vitamin D	insulin	MESH:D014807	3630	Chemical	Gene	deficiency|amod|START_ENTITY subjects|nmod|deficiency Effect|nmod|subjects Effect|nmod|sensitivity sensitivity|compound|END_ENTITY	Effect of vitamin_D replacement on insulin sensitivity in subjects with vitamin_D deficiency .
23264189	0	vitamin_D	8,17	insulin	40,47	vitamin D	insulin	MESH:D014807	3630	Chemical	Gene	START_ENTITY|nmod|development development|nmod|END_ENTITY	Role of vitamin_D in the development of insulin resistance and type 2 diabetes .
23303986	0	vitamin_D	69,78	insulin	43,50	vitamin D	insulin	MESH:D014807	3630	Chemical	Gene	levels|amod|START_ENTITY diazoxide|nmod|levels decreasing|nmod|diazoxide decreasing|dobj|END_ENTITY	A pilot study : effects of decreasing serum insulin with diazoxide on vitamin_D levels in obese women with polycystic_ovary_syndrome .
23443033	0	vitamin_D	14,23	insulin	27,34	vitamin D	insulin	MESH:D014807	3630	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	The effect of vitamin_D on insulin resistance in patients with type 2 diabetes .
23602243	0	vitamin_D	101,110	insulin	55,62	vitamin D	insulin	MESH:D014807	3630	Chemical	Gene	levels|amod|START_ENTITY disparities|nmod|levels resistance|nmod|disparities resistance|compound|END_ENTITY	Association of racial disparities in the prevalence of insulin resistance with racial disparities in vitamin_D levels : National Health and Nutrition Examination Survey -LRB- 2001-2006 -RRB- .
23674796	0	vitamin_D	46,55	insulin	68,75	vitamin D	insulin	MESH:D014807	3630	Chemical	Gene	status|amod|START_ENTITY status|nmod|resistance resistance|compound|END_ENTITY	A novel approach localizes the association of vitamin_D status with insulin resistance to one region of the 25-hydroxyvitamin_D continuum .
23685025	0	vitamin_D	49,58	insulin	5,12	vitamin D	insulin	MESH:D014807	3630	Chemical	Gene	status|amod|START_ENTITY alter|dobj|status alter|nsubj|resistance resistance|compound|END_ENTITY	Does insulin resistance in type 2 diabetes alter vitamin_D status ?
23900423	0	vitamin_D	20,29	insulin	33,40	vitamin D	insulin	MESH:D014807	3630	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	The effects of oral vitamin_D on insulin resistance in pre-diabetic patients .
24198221	0	vitamin_D	34,43	insulin	53,60	vitamin D	insulin	MESH:D014807	3630	Chemical	Gene	trial|amod|START_ENTITY controlled|dobj|trial controlled|nmod|resistance resistance|compound|END_ENTITY	Effect of a randomised controlled vitamin_D trial on insulin resistance and glucose metabolism in patients with type_2_diabetes_mellitus .
24632644	0	vitamin_D	11,20	insulin	35,42	vitamin D	insulin	MESH:D014807	3630	Chemical	Gene	correction|amod|START_ENTITY Effect|nmod|correction Effect|nmod|resistance resistance|compound|END_ENTITY	-LSB- Effect of vitamin_D correction on insulin resistance in patients with coronary_heart_disease and metabolic_syndrome -RSB- .
24636395	0	vitamin_D	10,19	insulin	52,59	vitamin D	insulin	MESH:D014807	3630	Chemical	Gene	supplementation|amod|START_ENTITY supplementation|nmod|sensitivity sensitivity|compound|END_ENTITY	High-dose vitamin_D supplementation and measures of insulin sensitivity in polycystic_ovary_syndrome : a randomized , controlled pilot trial .
24898240	0	vitamin_D	24,33	insulin	53,60	vitamin D	insulin	MESH:D014807	3630	Chemical	Gene	supplementation|amod|START_ENTITY supplementation|nmod|sensitivity sensitivity|compound|END_ENTITY	Effect of moderate-dose vitamin_D supplementation on insulin sensitivity in vitamin_D-deficient non-Western immigrants in the Netherlands : a randomized placebo-controlled trial .
24991591	0	vitamin_D	36,45	insulin	55,62	vitamin D	insulin	MESH:D014807	3630	Chemical	Gene	resistance|amod|START_ENTITY resistance|compound|END_ENTITY	Does the intramuscular injection of vitamin_D increase insulin resistance ?
25045275	0	vitamin_D	51,60	insulin	21,28	vitamin D	insulin	MESH:D014807	3630	Chemical	Gene	START_ENTITY|nsubj|Relationship Relationship|nmod|resistance resistance|compound|END_ENTITY	Relationship between insulin resistance and plasma vitamin_D in adults .
25145881	0	vitamin_D	7,16	insulin	44,51	vitamin D	insulin	MESH:D014807	3630	Chemical	Gene	associated|nsubjpass|START_ENTITY associated|advcl|fasting fasting|dobj|assessment assessment|compound|END_ENTITY	Plasma vitamin_D is associated with fasting insulin and homeostatic model assessment of insulin resistance in young adult males , but not females , of the Jerusalem Perinatal Study .
25145881	0	vitamin_D	7,16	insulin	88,95	vitamin D	insulin	MESH:D014807	3630	Chemical	Gene	associated|nsubjpass|START_ENTITY associated|advcl|fasting fasting|dobj|assessment assessment|nmod|resistance resistance|compound|END_ENTITY	Plasma vitamin_D is associated with fasting insulin and homeostatic model assessment of insulin resistance in young adult males , but not females , of the Jerusalem Perinatal Study .
25622671	0	vitamin_D	12,21	insulin	41,48	vitamin D	insulin	MESH:D014807	3630	Chemical	Gene	supplementation|amod|START_ENTITY Effects|nmod|supplementation Effects|nmod|resistance resistance|compound|END_ENTITY	-LSB- Effects of vitamin_D supplementation on insulin resistance in patients with type_2_diabetes_mellitus -RSB- .
2647606	0	vitamin_D	57,66	insulin	20,27	vitamin D	insulin	MESH:D014807	3630	Chemical	Gene	metabolism|amod|START_ENTITY modalities|nmod|metabolism modalities|nsubj|Effect Effect|nmod|administration administration|compound|END_ENTITY	Effect of different insulin administration modalities on vitamin_D metabolism of insulin-dependent diabetic patients .
26890031	0	vitamin_D	49,58	insulin	24,31	vitamin D	insulin	MESH:D014807	3630	Chemical	Gene	supplementation|amod|START_ENTITY levels|nmod|supplementation levels|compound|END_ENTITY	Differences in HOMA and insulin levels following vitamin_D supplementation in healthy men : A randomized double blind controlled trial .
8690178	0	vitamin_D	71,80	insulin	38,45	vitamin D	insulin	MESH:D014807	3630	Chemical	Gene	deficiency|amod|START_ENTITY secretion|nmod|deficiency secretion|nsubj|Glucose_intolerance Glucose_intolerance|nmod|END_ENTITY	Glucose_intolerance and impairment of insulin secretion in relation to vitamin_D deficiency in east London Asians .
24338253	0	vitamin_D	15,24	interleukin-13	59,73	vitamin D	interleukin-13	MESH:D014807	3596	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|cells cells|amod|END_ENTITY	The effects of vitamin_D on allergen-induced expression of interleukin-13 and interleukin-17 in cord blood CD4 T cells .
26198928	0	vitamin_D	20,29	interleukin-17	40,54	vitamin D	interleukin-17	MESH:D014807	3605	Chemical	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	Effect of high dose vitamin_D intake on interleukin-17 levels in multiple_sclerosis : A randomized , double-blind , placebo-controlled clinical trial .
26198928	0	vitamin_D	20,29	interleukin-17	40,54	vitamin D	interleukin-17	MESH:D014807	3605	Chemical	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	Effect of high dose vitamin_D intake on interleukin-17 levels in multiple_sclerosis : A randomized , double-blind , placebo-controlled clinical trial .
12445200	0	vitamin_D	4,13	involucrin	38,48	vitamin D	involucrin	MESH:D014807	3713	Chemical	Gene	element|amod|START_ENTITY element|nmod|gene gene|compound|END_ENTITY	The vitamin_D response element of the involucrin gene mediates its regulation by 1,25-dihydroxyvitamin _ D3 .
20236613	0	vitamin_D	87,96	ligand-binding_pocket	58,79	vitamin D	ligand-binding pocket	MESH:D014807	3929	Chemical	Gene	receptor|amod|START_ENTITY END_ENTITY|nmod|receptor	Interactions between 1alpha ,25 -LRB- OH -RRB- 2D3 and residues in the ligand-binding_pocket of the vitamin_D receptor : a correlated fragment molecular orbital study .
10505692	0	vitamin_D	24,33	lipoprotein_lipase	61,79	vitamin D	lipoprotein lipase	MESH:D014807	4023	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Antagonistic effects of vitamin_D and parathyroid_hormone on lipoprotein_lipase in cultured adipocytes .
22559908	0	vitamin_D	19,28	mannose_binding_lectin	47,69	vitamin D	mannose binding lectin	MESH:D014807	4153	Chemical	Gene	levels|nmod|START_ENTITY levels|nmod|END_ENTITY	Elevated levels of vitamin_D and deficiency of mannose_binding_lectin in dengue_hemorrhagic_fever .
9013768	0	vitamin_D	34,43	osteocalcin	72,83	vitamin D	osteocalcin	MESH:D014807	81613(Tax:10116)	Chemical	Gene	element|amod|START_ENTITY element|nmod|gene gene|compound|END_ENTITY	DNA sequences downstream from the vitamin_D response element of the rat osteocalcin gene are required for ligand-dependent transactivation .
9112412	0	vitamin_D	160,169	osteocalcin	185,196	vitamin D	osteocalcin	MESH:D014807	12097(Tax:10090)	Chemical	Gene	START_ENTITY|dobj|expression expression|compound|END_ENTITY	Species-specific glucocorticoid and_1 ,25 - dihydroxyvitamin_D responsiveness in mouse MC3T3-E1 osteoblasts : dexamethasone inhibits osteoblast differentiation and vitamin_D down-regulates osteocalcin gene expression .
9333117	0	vitamin_D	86,95	osteocalcin	12,23	vitamin D	osteocalcin	MESH:D014807	12097(Tax:10090)	Chemical	Gene	regulation|amod|START_ENTITY reveals|nmod|regulation reveals|nsubj|Analysis Analysis|nmod|expression expression|compound|END_ENTITY	Analysis of osteocalcin expression in transgenic_mice reveals a species difference in vitamin_D regulation of mouse and human osteocalcin genes .
9333117	0	vitamin_D	86,95	osteocalcin	126,137	vitamin D	osteocalcin	MESH:D014807	12097(Tax:10090)	Chemical	Gene	regulation|amod|START_ENTITY regulation|nmod|genes genes|compound|END_ENTITY	Analysis of osteocalcin expression in transgenic_mice reveals a species difference in vitamin_D regulation of mouse and human osteocalcin genes .
24044969	0	vitamin_D	17,26	p21	146,149	vitamin D	p21	MESH:D014807	644914	Chemical	Gene	START_ENTITY|nmod|upregulation upregulation|nmod|END_ENTITY	MART-10 , a novel vitamin_D analog , inhibits head and neck squamous_carcinoma cells growth through cell cycle arrest at G0/G1 with upregulation of p21 and p27 and downregulation of telomerase .
10571682	0	vitamin_D	112,121	parathyroid_hormone	45,64	vitamin D	parathyroid hormone	MESH:D014807	24694(Tax:10116)	Chemical	Gene	elements|amod|START_ENTITY effects|nmod|elements interactions|dep|effects interactions|nmod|gene gene|compound|END_ENTITY	Vitamin_D_receptor interactions with the rat parathyroid_hormone gene : synergistic effects between two negative vitamin_D response elements .
10633456	0	vitamin_D	46,55	parathyroid_hormone	18,37	vitamin D	parathyroid hormone	MESH:D014807	24694(Tax:10116)	Chemical	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|gene gene|amod|END_ENTITY	Regulation of the parathyroid_hormone gene by vitamin_D , calcium and phosphate .
12637645	0	vitamin_D	43,52	parathyroid_hormone	74,93	vitamin D	parathyroid hormone	MESH:D014807	5741	Chemical	Gene	analogue|amod|START_ENTITY analogue|acl:relcl|lowers lowers|xcomp|END_ENTITY	Pharmacokinetics of doxercalciferol , a new vitamin_D analogue that lowers parathyroid_hormone .
12730772	0	vitamin_D	78,87	parathyroid_hormone	27,46	vitamin D	parathyroid hormone	MESH:D014807	5741	Chemical	Gene	status|amod|START_ENTITY definition|nmod|status aid|dobj|definition aid|nsubj|END_ENTITY	In a population study , can parathyroid_hormone aid the definition of adequate vitamin_D status ?
14729578	0	vitamin_D	159,168	parathyroid_hormone	74,93	vitamin D	parathyroid hormone	MESH:D014807	5741	Chemical	Gene	influenced|nmod|START_ENTITY influenced|nmod|END_ENTITY	The prostate 25-hydroxyvitamin_D-1 alpha-hydroxylase is not influenced by parathyroid_hormone and calcium : implications for prostate_cancer chemoprevention by vitamin_D .
15297458	0	vitamin_D	112,121	parathyroid_hormone	25,44	vitamin D	parathyroid hormone	MESH:D014807	5741	Chemical	Gene	element|amod|START_ENTITY NF-Y|nmod|element displacement|nmod|NF-Y involves|dobj|displacement involves|nsubj|Suppression Suppression|nmod|promoter promoter|compound|END_ENTITY	Suppression of the human parathyroid_hormone promoter by vitamin_D involves displacement of NF-Y binding to the vitamin_D response element .
15297458	0	vitamin_D	57,66	parathyroid_hormone	25,44	vitamin D	parathyroid hormone	MESH:D014807	5741	Chemical	Gene	promoter|nmod|START_ENTITY promoter|compound|END_ENTITY	Suppression of the human parathyroid_hormone promoter by vitamin_D involves displacement of NF-Y binding to the vitamin_D response element .
16076350	0	vitamin_D	52,61	parathyroid_hormone	8,27	vitamin D	parathyroid hormone	MESH:D014807	5741	Chemical	Gene	sterols|amod|START_ENTITY Role|nmod|sterols Role|nmod|END_ENTITY	Role of parathyroid_hormone and therapy with active vitamin_D sterols in renal_osteodystrophy .
16960175	0	vitamin_D	8,17	parathyroid_hormone	35,54	vitamin D	parathyroid hormone	MESH:D014807	5741	Chemical	Gene	START_ENTITY|dobj|concentrations concentrations|compound|END_ENTITY	Optimal vitamin_D status and serum parathyroid_hormone concentrations in African American women .
17578859	0	vitamin_D	115,124	parathyroid_hormone	61,80	vitamin D	parathyroid hormone	MESH:D014807	5741	Chemical	Gene	regulation|compound|START_ENTITY importance|nmod|regulation indicate|dobj|importance indicate|nsubj|study study|nmod|levels levels|compound|END_ENTITY	A longitudinal study of serum 25-hydroxyvitamin_D and intact parathyroid_hormone levels indicate the importance of vitamin_D and calcium homeostasis regulation in multiple_sclerosis .
18957950	0	vitamin_D	17,26	parathyroid_hormone	51,70	vitamin D	parathyroid hormone	MESH:D014807	5741	Chemical	Gene	analogs|amod|START_ENTITY analogs|nmod|END_ENTITY	Calcimimetics or vitamin_D analogs for suppressing parathyroid_hormone in end-stage_renal_disease : time for a paradigm shift ?
19473453	0	vitamin_D	68,77	parathyroid_hormone	4,23	vitamin D	parathyroid hormone	MESH:D014807	5741	Chemical	Gene	deficiency|amod|START_ENTITY END_ENTITY|nmod|deficiency	Low parathyroid_hormone levels in bedridden geriatric patients with vitamin_D deficiency .
19539290	0	vitamin_D	6,15	parathyroid_hormone	17,36	vitamin D	parathyroid hormone	MESH:D014807	5741	Chemical	Gene	START_ENTITY|dobj|levels levels|amod|END_ENTITY	Serum vitamin_D , parathyroid_hormone levels , and carotid_atherosclerosis .
20148911	0	vitamin_D	24,33	parathyroid_hormone	44,63	vitamin D	parathyroid hormone	MESH:D014807	5741	Chemical	Gene	status|amod|START_ENTITY status|nmod|mass mass|compound|END_ENTITY	Discrepant influence of vitamin_D status on parathyroid_hormone and bone mass after two years of calcium supplementation .
20484452	0	vitamin_D	14,23	parathyroid_hormone	56,75	vitamin D	parathyroid hormone	MESH:D014807	5741	Chemical	Gene	status|amod|START_ENTITY Predictors|nmod|status Predictors|nmod|END_ENTITY	Predictors of vitamin_D status and its association with parathyroid_hormone in young New Zealand children .
20672993	0	vitamin_D	32,41	parathyroid_hormone	54,73	vitamin D	parathyroid hormone	MESH:D014807	5741	Chemical	Gene	exacerbates|nsubj|START_ENTITY exacerbates|dobj|elevations elevations|amod|END_ENTITY	Short communication : Inadequate vitamin_D exacerbates parathyroid_hormone elevations in tenofovir users .
2082223	0	vitamin_D	60,69	parathyroid_hormone	25,44	vitamin D	parathyroid hormone	MESH:D014807	5741	Chemical	Gene	intake|amod|START_ENTITY relation|nmod|intake fluctuations|nmod|relation fluctuations|nmod|END_ENTITY	Seasonal fluctuations in parathyroid_hormone in relation to vitamin_D intake of postmenopausal women .
20957441	0	vitamin_D	91,100	parathyroid_hormone	27,46	vitamin D	parathyroid hormone	MESH:D014807	5741	Chemical	Gene	supplementation|amod|START_ENTITY need|nmod|supplementation predicting|dobj|need END_ENTITY|advcl|predicting	The value of postoperative parathyroid_hormone levels in predicting the need for long-term vitamin_D supplementation after total thyroidectomy .
21287159	0	vitamin_D	75,84	parathyroid_hormone	8,27	vitamin D	parathyroid hormone	MESH:D014807	5741	Chemical	Gene	insufficiency|amod|START_ENTITY women|nmod|insufficiency Role|nmod|women Role|nmod|END_ENTITY	Role of parathyroid_hormone in bone_fragility of postmenopausal women with vitamin_D insufficiency .
22785083	0	vitamin_D	115,124	parathyroid_hormone	15,34	vitamin D	parathyroid hormone	MESH:D014807	5741	Chemical	Gene	insufficiency|amod|START_ENTITY Association|nmod|insufficiency Association|nmod|levels levels|amod|END_ENTITY	Association of parathyroid_hormone and 25-OH-vitamin_D levels with arterial stiffness in postmenopausal women with vitamin_D insufficiency .
22889840	0	vitamin_D	74,83	parathyroid_hormone	105,124	vitamin D	parathyroid hormone	MESH:D014807	5741	Chemical	Gene	status|amod|START_ENTITY restoration|nmod|status restoration|nmod|END_ENTITY	Cholecalciferol supplementation_in_chronic_kidney_disease : restoration of vitamin_D status and impact on parathyroid_hormone .
22968355	0	vitamin_D	20,29	parathyroid_hormone	66,85	vitamin D	parathyroid hormone	MESH:D014807	5741	Chemical	Gene	levels|compound|START_ENTITY reduce|nsubj|levels reduce|dobj|accuracy accuracy|nmod|END_ENTITY	Do low preoperative vitamin_D levels reduce the accuracy of quick parathyroid_hormone in predicting postthyroidectomy_hypocalcemia ?
23144810	0	vitamin_D	19,28	parathyroid_hormone	85,104	vitamin D	parathyroid hormone	MESH:D014807	5741	Chemical	Gene	insufficiency|amod|START_ENTITY prevalence|nmod|insufficiency prevalence|dep|relationship relationship|nmod|levels levels|nmod|END_ENTITY	High prevalence of vitamin_D insufficiency in China : relationship with the levels of parathyroid_hormone and markers of bone turnover .
23790578	0	vitamin_D	79,88	parathyroid_hormone	18,37	vitamin D	parathyroid hormone	MESH:D014807	5741	Chemical	Gene	-RSB-|amod|START_ENTITY patients|nmod|-RSB- Relation|nmod|patients Relation|nmod|risk risk|amod|END_ENTITY	-LSB- Relation between parathyroid_hormone and cardiovascular risk in patients with vitamin_D deficiency -RSB- .
24334134	0	vitamin_D	106,115	parathyroid_hormone	42,61	vitamin D	parathyroid hormone	MESH:D014807	5741	Chemical	Gene	-RSB-|amod|START_ENTITY considering|dobj|-RSB- value|xcomp|considering value|nmod|END_ENTITY	-LSB- Clinical value of two methods to measure parathyroid_hormone in chronic renal_insufficiency , considering vitamin_D metabolism -RSB- .
24854296	0	vitamin_D	17,26	parathyroid_hormone	45,64	vitamin D	parathyroid hormone	MESH:D014807	5741	Chemical	Gene	suppresses|amod|START_ENTITY END_ENTITY|nsubj|suppresses	Novel , selective vitamin_D analog suppresses parathyroid_hormone in uremic animals and postmenopausal women .
25582993	0	vitamin_D	51,60	parathyroid_hormone	61,80	vitamin D	parathyroid hormone	MESH:D014807	5741	Chemical	Gene	system|amod|START_ENTITY system|compound|END_ENTITY	-LSB- Osteoporosis in Rheumatoid_Arthritis : role of the vitamin_D / parathyroid_hormone system . -RSB-
25695075	0	vitamin_D	120,129	parathyroid_hormone	76,95	vitamin D	parathyroid hormone	MESH:D014807	5741	Chemical	Gene	deficiency|amod|START_ENTITY subjects|nmod|deficiency associated|nmod|subjects associated|nmod|levels levels|compound|END_ENTITY	R990G polymorphism of calcium_sensing_receptor gene is associated with high parathyroid_hormone levels in subjects with vitamin_D deficiency : a cross-sectional study .
2594036	0	vitamin_D	10,19	parathyroid_hormone	53,72	vitamin D	parathyroid hormone	MESH:D014807	5741	Chemical	Gene	intake|amod|START_ENTITY Effect|nmod|intake Effect|nmod|variations variations|nmod|secretion secretion|amod|END_ENTITY	Effect of vitamin_D intake on seasonal variations in parathyroid_hormone secretion in postmenopausal women .
26212698	0	vitamin_D	37,46	parathyroid_hormone	6,25	vitamin D	parathyroid hormone	MESH:D014807	5741	Chemical	Gene	START_ENTITY|nsubj|Serum Serum|amod|END_ENTITY	Serum parathyroid_hormone and active vitamin_D in chronic periodontitis .
26337807	0	vitamin_D	48,57	parathyroid_hormone	16,35	vitamin D	parathyroid hormone	MESH:D014807	5741	Chemical	Gene	supplementation|amod|START_ENTITY response|nmod|supplementation response|amod|END_ENTITY	Determinants of parathyroid_hormone response to vitamin_D supplementation : a systematic review and meta-analysis of randomised controlled trials .
26827062	0	vitamin_D	17,26	parathyroid_hormone	28,47	vitamin D	parathyroid hormone	MESH:D014807	5741	Chemical	Gene	Bisphosphonates|acl|START_ENTITY END_ENTITY|nsubj|Bisphosphonates	Bisphosphonates , vitamin_D , parathyroid_hormone , and osteonecrosis of the jaw .
2850724	0	vitamin_D	8,17	parathyroid_hormone	59,78	vitamin D	parathyroid hormone	MESH:D014807	24694(Tax:10116)	Chemical	Gene	metabolites|amod|START_ENTITY potentiate|nsubj|metabolites potentiate|dobj|expression expression|nmod|bioactivity bioactivity|amod|END_ENTITY	Certain vitamin_D metabolites potentiate the expression of parathyroid_hormone bioactivity .
3071395	0	vitamin_D	127,136	parathyroid_hormone	51,70	vitamin D	parathyroid hormone	MESH:D014807	24694(Tax:10116)	Chemical	Gene	metabolism|amod|START_ENTITY correlation|nmod|metabolism Effect|dep|correlation Effect|nmod|cyclase cyclase|amod|END_ENTITY	Effect of long-term and short-term diabetes on the parathyroid_hormone sensitive rat renal adenylate cyclase : correlation with vitamin_D metabolism .
3771798	0	vitamin_D	14,23	parathyroid_hormone	39,58	vitamin D	parathyroid hormone	MESH:D014807	24694(Tax:10116)	Chemical	Gene	metabolites|amod|START_ENTITY Regulation|nmod|metabolites Regulation|nmod|transcription transcription|amod|END_ENTITY	Regulation by vitamin_D metabolites of parathyroid_hormone gene transcription in vivo in the rat .
3991537	1	vitamin_D	69,78	parathyroid_hormone	101,120	vitamin D	parathyroid hormone	MESH:D014807	5741	Chemical	Gene	metabolites|amod|START_ENTITY Influence|nmod|metabolites END_ENTITY|nsubj|Influence	Influence of vitamin_D metabolites and serum parathyroid_hormone .
6246805	0	vitamin_D	11,20	parathyroid_hormone	43,62	vitamin D	parathyroid hormone	MESH:D014807	280903(Tax:9913)	Chemical	Gene	metabolites|amod|START_ENTITY metabolites|nmod|END_ENTITY	Effects of vitamin_D metabolites on bovine parathyroid_hormone release in vitro .
6264377	0	vitamin_D	33,42	parathyroid_hormone	10,29	vitamin D	parathyroid hormone	MESH:D014807	5741	Chemical	Gene	metabolism|amod|START_ENTITY Effect|nmod|metabolism Effect|nmod|END_ENTITY	Effect of parathyroid_hormone on vitamin_D metabolism in osteopetrosis .
6271531	0	vitamin_D	14,23	parathyroid_hormone	102,121	vitamin D	parathyroid hormone	MESH:D014807	24694(Tax:10116)	Chemical	Gene	restriction|amod|START_ENTITY effect|nmod|restriction effect|nmod|END_ENTITY	The effect of vitamin_D restriction and repletion on bone apposition in the rat and its dependence on parathyroid_hormone .
6279352	0	vitamin_D	74,83	parathyroid_hormone	45,64	vitamin D	parathyroid hormone	MESH:D014807	5741	Chemical	Gene	deficiency|amod|START_ENTITY END_ENTITY|nmod|deficiency	Reversible resistance to the renal action of parathyroid_hormone in human vitamin_D deficiency .
6547026	0	vitamin_D	64,73	parathyroid_hormone	33,52	vitamin D	parathyroid hormone	MESH:D014807	396436(Tax:9031)	Chemical	Gene	effect|nmod|START_ENTITY Responses|dep|effect Responses|nmod|cell cell|nmod|END_ENTITY	Responses of chick renal cell to parathyroid_hormone : effect of vitamin_D .
6744632	0	vitamin_D	112,121	parathyroid_hormone	47,66	vitamin D	parathyroid hormone	MESH:D014807	5741	Chemical	Gene	deficiency|amod|START_ENTITY comparison|nmod|deficiency investigation|dep|comparison investigation|nmod|activity activity|nmod|END_ENTITY	An investigation of the biological activity of parathyroid_hormone in pseudohypoparathyroidism : comparison with vitamin_D deficiency .
6978888	0	vitamin_D	40,49	parathyroid_hormone	17,36	vitamin D	parathyroid hormone	MESH:D014807	5741	Chemical	Gene	metabolism|amod|START_ENTITY effects|nmod|metabolism effects|nmod|END_ENTITY	Acute effects of parathyroid_hormone on vitamin_D metabolism in patients with the bone_loss_of_aging .
7297490	0	vitamin_D	42,51	parathyroid_hormone	81,100	vitamin D	parathyroid hormone	MESH:D014807	24694(Tax:10116)	Chemical	Gene	deficiency|amod|START_ENTITY development|nmod|deficiency differences|nmod|development differences|dep|serum serum|dep|END_ENTITY	Sex differences during the development of vitamin_D deficiency in the rat : serum parathyroid_hormone , calcitonin , calcium , and phosphorus .
7565453	0	vitamin_D	19,28	parathyroid_hormone	56,75	vitamin D	parathyroid hormone	MESH:D014807	5741	Chemical	Gene	START_ENTITY|nmod|levels levels|nmod|metabolites metabolites|amod|END_ENTITY	Effects of dietary vitamin_D intake on plasma levels of parathyroid_hormone and vitamin_D metabolites in healthy Japanese .
7786039	0	vitamin_D	49,58	parathyroid_hormone	102,121	vitamin D	parathyroid hormone	MESH:D014807	24694(Tax:10116)	Chemical	Gene	toxicity|amod|START_ENTITY physiology|nmod|toxicity calcium|nmod|physiology role|nmod|calcium role|dep|induction induction|compound|END_ENTITY	The role of dietary calcium in the physiology of vitamin_D toxicity : excess dietary vitamin_D3 blunts parathyroid_hormone induction of kidney 1-hydroxylase .
8212205	0	vitamin_D	21,30	parathyroid_hormone	118,137	vitamin D	parathyroid hormone	MESH:D014807	5741	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|wasting wasting|amod|END_ENTITY	Effect of daily oral vitamin_D and calcium therapy , hypophosphatemia , and endogenous 1-25_dihydroxycholecalciferol on parathyroid_hormone and phosphate wasting in renal transplant recipients .
8920918	0	vitamin_D	23,32	parathyroid_hormone	58,77	vitamin D	parathyroid hormone	MESH:D014807	280903(Tax:9913)	Chemical	Gene	elements|amod|START_ENTITY analysis|nmod|elements analysis|nmod|gene gene|amod|END_ENTITY	Functional analysis of vitamin_D response elements in the parathyroid_hormone gene and a comparison with the osteocalcin gene .
21606711	0	vitamin_D	26,35	part_1	48,54	vitamin D	part 1	MESH:D014807	25859	Chemical	Gene	deficiency|amod|START_ENTITY deficiency|appos|END_ENTITY	Protean manifestations of vitamin_D deficiency , part_1 : the epidemic_of_deficiency .
3665123	0	vitamin_D	119,128	prolactin	88,97	vitamin D	prolactin	MESH:D014807	5617	Chemical	Gene	metabolism|amod|START_ENTITY regulation|nmod|metabolism END_ENTITY|nmod|regulation	Remission of hypoparathyroidism during lactation : evidence for a physiological role for prolactin in the regulation of vitamin_D metabolism .
6896886	0	vitamin_D	21,30	prolactin	8,17	vitamin D	prolactin	MESH:D014807	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of prolactin in vitamin_D metabolism and calcium absorption during lactation in the rat .
955248	0	vitamin_D	23,32	prolactin	10,19	vitamin D	prolactin	MESH:D014807	396453(Tax:9031)	Chemical	Gene	metabolism|amod|START_ENTITY Effect|nmod|metabolism Effect|nmod|END_ENTITY	Effect of prolactin on vitamin_D metabolism .
23738846	0	vitamin_D	7,16	protease_inhibitor	79,97	vitamin D	protease inhibitor	MESH:D014807	388007	Chemical	Gene	START_ENTITY|nmod|monotherapy monotherapy|compound|END_ENTITY	Higher vitamin_D levels in HIV-infected out-patients on treatment with boosted protease_inhibitor monotherapy .
23645099	0	vitamin_D	28,37	renin	65,70	vitamin D	renin	MESH:D014807	5972	Chemical	Gene	START_ENTITY|nmod|system system|compound|END_ENTITY	Effect of acute and chronic vitamin_D administration on systemic renin angiotensin system in essential hypertensives and controls .
24488080	0	vitamin_D	23,32	sclerostin	54,64	vitamin D	sclerostin	MESH:D014807	50964	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|compound|END_ENTITY	Effect of supplemental vitamin_D and calcium on serum sclerostin levels .
25366373	0	vitamin_D	109,118	sclerostin	35,45	vitamin D	sclerostin	MESH:D014807	50964	Chemical	Gene	level|amod|START_ENTITY Associations|nmod|level Associations|nmod|levels levels|nmod|END_ENTITY	Associations between the levels of sclerostin , phosphate , and fibroblast_growth_factor-23 and treatment with vitamin_D in hemodialysis patients with low intact PTH level .
26007153	0	vitamin_D	40,49	sclerostin	6,16	vitamin D	sclerostin	MESH:D014807	50964	Chemical	Gene	treatment|amod|START_ENTITY decreased|nmod|treatment decreased|nsubjpass|END_ENTITY	Serum sclerostin is decreased following vitamin_D treatment in young vitamin_D-deficient female adults .
26007153	0	vitamin_D	40,49	sclerostin	6,16	vitamin D	sclerostin	MESH:D014807	50964	Chemical	Gene	treatment|amod|START_ENTITY decreased|nmod|treatment decreased|nsubjpass|END_ENTITY	Serum sclerostin is decreased following vitamin_D treatment in young vitamin_D-deficient female adults .
26352089	0	vitamin_D	45,54	sclerostin	10,20	vitamin D	sclerostin	MESH:D014807	50964	Chemical	Gene	deficiency|amod|START_ENTITY newborns|nmod|deficiency serum|nmod|newborns serum|dobj|levels levels|compound|END_ENTITY	Low serum sclerostin levels in newborns with vitamin_D deficiency .
1525046	0	vitamin_D	62,71	vitamin_D-binding_protein	94,119	vitamin D	vitamin D-binding protein	MESH:D014807	2638	Chemical	Gene	metabolites|amod|START_ENTITY metabolites|nmod|END_ENTITY	Polyunsaturated_fatty_acids decrease the apparent affinity of vitamin_D metabolites for human vitamin_D-binding_protein .
10234571	0	vitamin_D	31,40	vitamin_D_receptor	56,74	vitamin D	vitamin D receptor	MESH:D014807	7421	Chemical	Gene	effects|nmod|START_ENTITY analogs|nsubj|effects analogs|nmod|homodimer homodimer|compound|END_ENTITY	Differential effects of 20-epi vitamin_D analogs on the vitamin_D_receptor homodimer .
10347251	0	vitamin_D	91,100	vitamin_D_receptor	25,43	vitamin D	vitamin D receptor	MESH:D014807	7421	Chemical	Gene	analogs|amod|START_ENTITY selectivity|nmod|analogs mediates|dobj|selectivity mediates|nsubj|recognition recognition|nmod|conformations conformations|compound|END_ENTITY	Selective recognition of vitamin_D_receptor conformations mediates promoter selectivity of vitamin_D analogs .
11281654	0	vitamin_D	101,110	vitamin_D_receptor	37,55	vitamin D	vitamin D receptor	MESH:D014807	7421	Chemical	Gene	pathway|amod|START_ENTITY inhibits|dobj|pathway inhibits|nsubj|interacts interacts|nmod|END_ENTITY	BAG-1_p50 isoform interacts with the vitamin_D_receptor and its cellular overexpression inhibits the vitamin_D pathway .
11344183	0	vitamin_D	49,58	vitamin_D_receptor	16,34	vitamin D	vitamin D receptor	MESH:D014807	7421	Chemical	Gene	metabolism|amod|START_ENTITY regulating|dobj|metabolism END_ENTITY|acl|regulating	The role of the vitamin_D_receptor in regulating vitamin_D metabolism : a study of vitamin_D-dependent rickets , type II .
11834737	0	vitamin_D	30,39	vitamin_D_receptor	107,125	vitamin D	vitamin D receptor	MESH:D014807	7421	Chemical	Gene	elements|amod|START_ENTITY dinucleotide|nmod|elements modulates|nsubj|dinucleotide modulates|nmod|END_ENTITY	A central dinucleotide within vitamin_D response elements modulates DNA binding and transactivation by the vitamin_D_receptor in cellular response to natural and synthetic ligands .
12089348	0	vitamin_D	121,130	vitamin_D_receptor	56,74	vitamin D	vitamin D receptor	MESH:D014807	22337(Tax:10090)	Chemical	Gene	functions|nmod|START_ENTITY abrogates|dobj|functions abrogates|nsubj|Deletion Deletion|nmod|domain domain|nmod|END_ENTITY	Deletion of deoxyribonucleic acid binding domain of the vitamin_D_receptor abrogates genomic and nongenomic functions of vitamin_D .
14635194	0	vitamin_D	20,29	vitamin_D_receptor	127,145	vitamin D	vitamin D receptor	MESH:D014807	22337(Tax:10090)	Chemical	Gene	metabolites|amod|START_ENTITY actions|nmod|metabolites retained|nsubjpass|actions retained|nmod|mice mice|compound|END_ENTITY	Membrane actions of vitamin_D metabolites 1alpha ,25 -LRB- OH -RRB- 2D3 and 24R ,25 -LRB- OH -RRB- 2D3 are retained in growth plate cartilage cells from vitamin_D_receptor knockout mice .
14746673	0	vitamin_D	74,83	vitamin_D_receptor	20,38	vitamin D	vitamin D receptor	MESH:D014807	7421	Chemical	Gene	-RSB-|amod|START_ENTITY start|nmod|-RSB- start|nsubj|Association Association|nmod|gene gene|compound|END_ENTITY	-LSB- Association of the vitamin_D_receptor gene start codon polymorphism with vitamin_D deficiency rickets -RSB- .
15066918	0	vitamin_D	12,21	vitamin_D_receptor	51,69	vitamin D	vitamin D receptor	MESH:D014807	7421	Chemical	Gene	Circulating|dep|START_ENTITY Circulating|nsubj|metabolites metabolites|appos|polymorphism polymorphism|nmod|END_ENTITY	Circulating vitamin_D metabolites , polymorphism in vitamin_D_receptor , and colorectal_adenoma risk .
16860619	0	vitamin_D	31,40	vitamin_D_receptor	140,158	vitamin D	vitamin D receptor	MESH:D014807	7421	Chemical	Gene	intake|amod|START_ENTITY effect|nmod|intake modulated|nsubjpass|effect modulated|nmod|polymorphism polymorphism|nmod|END_ENTITY	The positive effect of dietary vitamin_D intake on bone_mineral_density in men is modulated by the polyadenosine repeat polymorphism of the vitamin_D_receptor .
19056816	0	vitamin_D	45,54	vitamin_D_receptor	19,37	vitamin D	vitamin D receptor	MESH:D014807	7421	Chemical	Gene	element|amod|START_ENTITY END_ENTITY|nmod|element	Interaction of the vitamin_D_receptor with a vitamin_D response element in the Mullerian-inhibiting_substance -LRB- MIS -RRB- promoter : regulation of MIS expression by calcitriol in prostate_cancer cells .
20966550	0	vitamin_D	141,150	vitamin_D_receptor	45,63	vitamin D	vitamin D receptor	MESH:D014807	7421	Chemical	Gene	amyloid-b|nmod|START_ENTITY suppression|acl|amyloid-b suppression|compound|END_ENTITY	A novel perspective for Alzheimer 's _ disease : vitamin_D_receptor suppression by amyloid-b and preventing the amyloid-b induced alterations by vitamin_D in cortical neurons .
21169421	0	vitamin_D	49,58	vitamin_D_receptor	114,132	vitamin D	vitamin D receptor	MESH:D014807	22337(Tax:10090)	Chemical	Gene	prohormones|amod|START_ENTITY expression|nmod|prohormones suppression|nmod|expression requires|nsubj|suppression requires|dobj|END_ENTITY	Direct suppression of Pth gene expression by the vitamin_D prohormones doxercalciferol and calcidiol requires the vitamin_D_receptor .
21433310	0	vitamin_D	90,99	vitamin_D_receptor	26,44	vitamin D	vitamin D receptor	MESH:D014807	7421	Chemical	Gene	-RSB-|amod|START_ENTITY polymorphism|nmod|-RSB- END_ENTITY|dobj|polymorphism	-LSB- Association between BsmI vitamin_D_receptor gene polymorphism and serum concentration of vitamin_D with progression of rheumatoid_arthritis -RSB- .
21860566	0	vitamin_D	102,111	vitamin_D_receptor	45,63	vitamin D	vitamin D receptor	MESH:D014807	7421	Chemical	Gene	resistant|dep|START_ENTITY rickets|amod|resistant girl|nmod|rickets gene|nmod|girl gene|compound|END_ENTITY	Novel compound heterozygous mutations in the vitamin_D_receptor gene in a Korean girl with hereditary vitamin_D resistant rickets .
21871642	0	vitamin_D	93,102	vitamin_D_receptor	15,33	vitamin D	vitamin D receptor	MESH:D014807	7421	Chemical	Gene	polymorphisms|xcomp|START_ENTITY polymorphisms|nsubj|Association Association|nmod|gene gene|compound|END_ENTITY	Association of vitamin_D_receptor gene polymorphisms with insulin resistance and response to vitamin_D .
23341935	0	vitamin_D	72,81	vitamin_D_receptor	19,37	vitamin D	vitamin D receptor	MESH:D014807	22337(Tax:10090)	Chemical	Gene	resistance|amod|START_ENTITY implications|nmod|resistance Down-regulation|dep|implications Down-regulation|nmod|END_ENTITY	Down-regulation of vitamin_D_receptor in mammospheres : implications for vitamin_D resistance in breast_cancer and potential for combination therapy .
23896933	0	vitamin_D	126,135	vitamin_D_receptor	71,89	vitamin D	vitamin D receptor	MESH:D014807	24873(Tax:10116)	Chemical	Gene	ligands|amod|START_ENTITY conformation|nmod|ligands elucidation|nmod|conformation study|dep|elucidation study|nmod|complex complex|nmod|derivatives derivatives|nmod|END_ENTITY	19F NMR study on the complex of fluorinated vitamin_D derivatives with vitamin_D_receptor : elucidation of the conformation of vitamin_D ligands accommodated in the receptor .
24558197	0	vitamin_D	69,78	vitamin_D_receptor	10,28	vitamin D	vitamin D receptor	MESH:D014807	7421	Chemical	Gene	status|amod|START_ENTITY neonatal|dobj|status related|xcomp|neonatal related|nsubjpass|END_ENTITY	Placental vitamin_D_receptor -LRB- VDR -RRB- expression is related to neonatal vitamin_D status , placental calcium transfer , and fetal bone length in pregnant adolescents .
25707738	0	vitamin_D	62,71	vitamin_D_receptor	28,46	vitamin D	vitamin D receptor	MESH:D014807	7421	Chemical	Gene	treatment|amod|START_ENTITY changes|nmod|treatment changes|nsubj|detection detection|nmod|END_ENTITY	Flow cytometry detection of vitamin_D_receptor changes during vitamin_D treatment in Crohn 's _ disease .
25707738	0	vitamin_D	62,71	vitamin_D_receptor	28,46	vitamin D	vitamin D receptor	MESH:D014807	7421	Chemical	Gene	treatment|amod|START_ENTITY changes|nmod|treatment changes|nsubj|detection detection|nmod|END_ENTITY	Flow cytometry detection of vitamin_D_receptor changes during vitamin_D treatment in Crohn 's _ disease .
26694996	0	vitamin_D	39,48	vitamin_D_receptor	81,99	vitamin D	vitamin D receptor	MESH:D014807	7421	Chemical	Gene	deficiency|amod|START_ENTITY circulating|nmod|deficiency Increase|acl|circulating linked|nsubjpass|Increase linked|nmod|activity activity|compound|END_ENTITY	Increase of circulating cholesterol in vitamin_D deficiency is linked to reduced vitamin_D_receptor activity via the Insig-2 / SREBP-2 pathway .
26722516	0	vitamin_D	15,24	vitamin_D_receptor	85,103	vitamin D	vitamin D receptor	MESH:D014807	7421	Chemical	Gene	signaling|advmod|START_ENTITY Alterations|acl|signaling Alterations|dep|study study|nmod|expression expression|compound|END_ENTITY	Alterations in vitamin_D signaling pathway in gastric_cancer progression : a study of vitamin_D_receptor expression in human normal , premalignant , and malignant gastric tissue .
8089197	0	vitamin_D	101,110	vitamin_D_receptor	14,32	vitamin D	vitamin D receptor	MESH:D014807	7421	Chemical	Gene	START_ENTITY|nsubj|Variations Variations|nmod|complexes complexes|compound|END_ENTITY	Variations in vitamin_D_receptor transcription factor complexes associated with the osteocalcin gene vitamin_D responsive element in osteoblasts and osteosarcoma cells .
8170473	0	vitamin_D	20,29	vitamin_D_receptor	113,131	vitamin D	vitamin D receptor	MESH:D014807	395988(Tax:9031)	Chemical	Gene	response|amod|START_ENTITY binding|nmod|response elements|amod|binding related|nsubjpass|elements related|nmod|END_ENTITY	Specific binding to vitamin_D response elements of chicken intestinal DNA-binding activity is not related to the vitamin_D_receptor .
8552086	0	vitamin_D	153,162	vitamin_D_receptor	32,50	vitamin D	vitamin D receptor	MESH:D014807	7421	Chemical	Gene	responsiveness|amod|START_ENTITY mediates|dobj|responsiveness mediates|nsubj|element element|acl|binding binding|dobj|END_ENTITY	A composite element binding the vitamin_D_receptor , retinoid_X_receptor_alpha , and a member of the CTF/NF -1 family of transcription factors mediates the vitamin_D responsiveness of the c-fos promoter .
8721985	0	vitamin_D	122,131	vitamin_D_receptor	51,69	vitamin D	vitamin D receptor	MESH:D014807	7421	Chemical	Gene	elements|amod|START_ENTITY transactivation|nmod|elements transactivation|compound|END_ENTITY	Retinoid X receptor isotype identity directs human vitamin_D_receptor heterodimer transactivation from the 24-hydroxylase vitamin_D response elements in yeast .
8841046	0	vitamin_D	51,60	vitamin_D_receptor	11,29	vitamin D	vitamin D receptor	MESH:D014807	7421	Chemical	Gene	therapy|amod|START_ENTITY polymorphism|nmod|therapy polymorphism|compound|END_ENTITY	-LSB- Effect of vitamin_D_receptor gene polymorphism on vitamin_D therapy for postmenopausal_bone_loss -RSB- .
8990171	0	vitamin_D	85,94	vitamin_D_receptor	14,32	vitamin D	vitamin D receptor	MESH:D014807	7421	Chemical	Gene	responsive|amod|START_ENTITY gene|amod|responsive transactivation|nmod|gene regulates|dep|transactivation regulates|dobj|END_ENTITY	YY1 regulates vitamin_D_receptor / retinoid_X_receptor mediated transactivation of the vitamin_D responsive osteocalcin gene .
9005998	0	vitamin_D	11,20	vitamin_D_receptor	73,91	vitamin D	vitamin D receptor	MESH:D014807	7421	Chemical	Gene	resistant|dep|START_ENTITY rickets|amod|resistant caused|nsubj|rickets caused|nmod|END_ENTITY	Hereditary vitamin_D resistant rickets caused by a novel mutation in the vitamin_D_receptor that results in decreased affinity for hormone and cellular hyporesponsiveness .
9058382	0	vitamin_D	12,21	vitamin_D_receptor	59,77	vitamin D	vitamin D receptor	MESH:D014807	7421	Chemical	Gene	heterodimerization|amod|START_ENTITY heterodimerization|nmod|END_ENTITY	Analysis of vitamin_D analog-induced heterodimerization of vitamin_D_receptor with retinoid X receptor using the yeast two-hybrid system .
9099905	0	vitamin_D	16,25	vitamin_D_receptor	82,100	vitamin D	vitamin D receptor	MESH:D014807	7421	Chemical	Gene	analogues|nsubj|START_ENTITY analogues|nmod|END_ENTITY	The noncalcemic vitamin_D analogues EB1089 and 22-oxacalcitriol interact with the vitamin_D_receptor and suppress parathyroid_hormone-related_peptide gene expression .
9191975	0	vitamin_D	81,90	vitamin_D_receptor	20,38	vitamin D	vitamin D receptor	MESH:D014807	7421	Chemical	Gene	responsive|amod|START_ENTITY element|amod|responsive occupied|nmod|element occupied|nsubj|binding binding|nmod|END_ENTITY	In vitro binding of vitamin_D_receptor occupied by 24R,25-dihydroxyvitamin _ D3 to vitamin_D responsive element of human osteocalcin gene .
9258754	0	vitamin_D	14,23	vitamin_D_receptor	107,125	vitamin D	vitamin D receptor	MESH:D014807	7421	Chemical	Gene	supplementation|amod|START_ENTITY effect|nmod|supplementation associated|nsubjpass|effect associated|nmod|genotype genotype|compound|END_ENTITY	The effect of vitamin_D supplementation on the bone_mineral_density of the femoral neck is associated with vitamin_D_receptor genotype .
9556566	0	vitamin_D	11,20	vitamin_D_receptor	105,123	vitamin D	vitamin D receptor	MESH:D014807	7421	Chemical	Gene	element|amod|START_ENTITY binds|nsubj|element binds|xcomp|END_ENTITY	A negative vitamin_D response DNA element in the human parathyroid_hormone-related peptide gene binds to vitamin_D_receptor along with Ku antigen to mediate negative gene regulation by vitamin_D .
9556566	0	vitamin_D	185,194	vitamin_D_receptor	105,123	vitamin D	vitamin D receptor	MESH:D014807	7421	Chemical	Gene	mediate|nmod|START_ENTITY END_ENTITY|xcomp|mediate	A negative vitamin_D response DNA element in the human parathyroid_hormone-related peptide gene binds to vitamin_D_receptor along with Ku antigen to mediate negative gene regulation by vitamin_D .
9627691	0	vitamin_D	63,72	vitamin_D_receptor	132,150	vitamin D	vitamin D receptor	MESH:D014807	7421	Chemical	Gene	analogs|amod|START_ENTITY effects|nmod|analogs determined|nsubjpass|effects determined|nmod|affinity affinity|nmod|END_ENTITY	The anti-proliferative and differentiation-inducing effects of vitamin_D analogs are not determined by the binding affinity for the vitamin_D_receptor alone .
9891040	0	vitamin_D	83,92	vitamin_D_receptor	25,43	vitamin D	vitamin D receptor	MESH:D014807	7421	Chemical	Gene	analog|amod|START_ENTITY coactivators|nmod|analog coactivators|nsubj|interaction interaction|nmod|END_ENTITY	Selective interaction of vitamin_D_receptor with transcriptional coactivators by a vitamin_D analog .
15650022	0	vitamin_D	27,36	vitamin_d_receptor	189,207	vitamin D	vitamin d receptor	MESH:D014807	7421	Chemical	Gene	actions|amod|START_ENTITY mechanism|nmod|actions depends|nsubj|mechanism depends|nmod|structure structure|nmod|region region|nmod|END_ENTITY	Molecular mechanism of the vitamin_D antagonistic actions of -LRB- 23S -RRB- -25 - dehydro-1alpha-hydroxyvitamin_D3-26 ,23 - lactone depends on the primary structure of the carboxyl-terminal region of the vitamin_d_receptor .
9541187	0	vitamin_D-regulated_gene	16,40	VDUP-1	42,48	vitamin D-regulated gene	VDUP-1	null	117514(Tax:10116)	Chemical	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of a vitamin_D-regulated_gene -LRB- VDUP-1 -RRB- in untreated - and MNU-treated rat mammary tissue .
12890894	0	vitamin_D2	58,68	DNA_polymerase_alpha	34,54	vitamin D2	DNA polymerase alpha	MESH:D004872	5422	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Selective inhibition of mammalian DNA_polymerase_alpha by vitamin_D2 and D3 .
11875645	0	vitamin_D3	10,20	Bcl-xL	52,58	vitamin D3	Bcl-xL	MESH:D002762	598	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of vitamin_D3 on the increased expression of Bcl-xL in psoriasis .
16158254	0	vitamin_D3	55,65	CYP27A1	84,91	vitamin D3	CYP27A1	MESH:D002762	1593	Chemical	Gene	cholecalciferol|appos|START_ENTITY prostate_cancer|nmod|cholecalciferol Chemoprevention|nmod|prostate_cancer Chemoprevention|dep|25-hydroxylase 25-hydroxylase|appos|END_ENTITY	Chemoprevention of prostate_cancer by cholecalciferol -LRB- vitamin_D3 -RRB- : 25-hydroxylase -LRB- CYP27A1 -RRB- in human prostate epithelial cells .
26638999	0	vitamin_D3	93,103	CYP27A1	20,27	vitamin D3	CYP27A1	MESH:D002762	1593	Chemical	Gene	hydroxylation|amod|START_ENTITY megaterium|nmod|hydroxylation megaterium|nsubj|Expression Expression|nmod|END_ENTITY	Expression of human CYP27A1 in B. _ megaterium for the efficient hydroxylation of cholesterol , vitamin_D3 and 7-dehydrocholesterol .
18511070	0	vitamin_D3	46,56	CYP2R1	23,29	vitamin D3	CYP2R1	MESH:D002762	120227	Chemical	Gene	analysis|nmod|START_ENTITY analysis|nmod|END_ENTITY	Structural analysis of CYP2R1 in complex with vitamin_D3 .
7667104	0	vitamin_D3	22,32	Calreticulin	0,12	vitamin D3	Calreticulin	MESH:D002762	64202(Tax:10116)	Chemical	Gene	transduction|amod|START_ENTITY inhibits|dobj|transduction inhibits|nsubj|END_ENTITY	Calreticulin inhibits vitamin_D3 signal transduction .
15746971	0	vitamin_D3	157,167	MMP-1	184,189	vitamin D3	MMP-1	MESH:D002762	4312	Chemical	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	Influence of mechanical and biological signals on gene expression in human MG-63 cells : evidence for a complex interplay between hydrostatic compression and vitamin_D3 or TGF-beta1 on MMP-1 and MMP-3 mRNA levels .
9536224	0	vitamin_D3	128,138	RANTES	0,6	vitamin D3	RANTES	MESH:D002762	6352	Chemical	Gene	cultured|nmod|START_ENTITY cultured|nsubj|END_ENTITY	RANTES expression in psoriatic skin , and regulation of RANTES and IL-8 production in cultured epidermal keratinocytes by active vitamin_D3 -LRB- tacalcitol -RRB- .
25866638	0	vitamin_D3	36,46	TSLP	0,4	vitamin D3	TSLP	MESH:D002762	85480	Chemical	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	TSLP is differentially regulated by vitamin_D3 and cytokines in human skin .
16158969	0	vitamin_D3	69,79	VDR	20,23	vitamin D3	VDR	MESH:D002762	7421	Chemical	Gene	compounds|amod|START_ENTITY expression|nmod|compounds expression|compound|END_ENTITY	Correlation between VDR expression and antiproliferative activity of vitamin_D3 compounds in combination with cytostatics .
16518840	1	vitamin_D3	112,122	VDR	167,170	vitamin D3	Sp1	MESH:D002762	6667	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|binding binding|nmod|vitamin_D3_receptor vitamin_D3_receptor|appos|END_ENTITY	Our previous study demonstrate that vitamin_D3 induces the binding of vitamin_D3_receptor -LRB- VDR -RRB- to Sp1 transcription factor and stimulates p27Kip1 expression via the Sp1 consensus sequences in the promoter .
18997319	0	vitamin_D3	87,97	VDR	46,49	vitamin D3	VDR	MESH:D002762	24873(Tax:10116)	Chemical	Gene	YR301|amod|START_ENTITY END_ENTITY|nmod|YR301	Structure of the ligand-binding domain of rat VDR in complex with the nonsecosteroidal vitamin_D3 analogue YR301 .
25827670	0	vitamin_D3	10,20	VDR	79,82	vitamin D3	VDR	MESH:D002762	7421	Chemical	Gene	supplementation|amod|START_ENTITY Effect|nmod|supplementation Effect|nmod|polymorphism polymorphism|nmod|gene gene|compound|END_ENTITY	Effect of vitamin_D3 supplementation and influence of BsmI polymorphism of the VDR gene of the inflammatory profile and oxidative stress in elderly women with vitamin_D insufficiency : Vitamin_D3 megadose reduces inflammatory markers .
9637681	0	vitamin_D3	48,58	VDR	110,113	vitamin D3	VDR	MESH:D002762	7421	Chemical	Gene	receptor|amod|START_ENTITY interacts|nmod|receptor complex|acl:relcl|interacts END_ENTITY|nsubj|complex	A novel protein complex that interacts with the vitamin_D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system .
18004750	0	vitamin_D3	33,43	beta-lactoglobulin	65,83	vitamin D3	beta-lactoglobulin	MESH:D002762	280838(Tax:9913)	Chemical	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Crystal structure of a secondary vitamin_D3 binding site of milk beta-lactoglobulin .
14657394	0	vitamin_D3	32,42	cytochrome_P450scc	105,123	vitamin D3	cytochrome P450scc	MESH:D002762	1583	Chemical	Gene	metabolism|nmod|START_ENTITY pathway|nmod|metabolism pathway|dep|metabolites metabolites|acl|formed formed|nmod|catalysis catalysis|nmod|END_ENTITY	A pathway for the metabolism of vitamin_D3 : unique hydroxylated metabolites formed during catalysis with cytochrome_P450scc -LRB- CYP11A1 -RRB- .
16098191	0	vitamin_D3	60,70	cytochrome_P450scc	4,22	vitamin D3	cytochrome P450scc	MESH:D002762	1583	Chemical	Gene	metabolism|amod|START_ENTITY pathway|nmod|metabolism opens|dobj|pathway opens|nsubj|system system|amod|END_ENTITY	The cytochrome_P450scc system opens an alternate pathway of vitamin_D3 metabolism .
18410379	0	vitamin_D3	44,54	cytochrome_P450scc	58,76	vitamin D3	cytochrome P450scc	MESH:D002762	1583	Chemical	Gene	metabolism|nmod|START_ENTITY Pathways|nmod|metabolism Pathways|nmod|END_ENTITY	Pathways and products for the metabolism of vitamin_D3 by cytochrome_P450scc .
18573681	0	vitamin_D3	12,22	cytochrome_P450scc	37,55	vitamin D3	cytochrome P450scc	MESH:D002762	1583	Chemical	Gene	metabolism|amod|START_ENTITY metabolism|nmod|END_ENTITY	Kinetics of vitamin_D3 metabolism by cytochrome_P450scc -LRB- CYP11A1 -RRB- in phospholipid vesicles and cyclodextrin .
8180120	0	vitamin_D3	75,85	estrone_sulfatase	32,49	vitamin D3	estrone sulfatase	MESH:D002762	412	Chemical	Gene	Lack|nmod|START_ENTITY Lack|nmod|END_ENTITY	Lack of inhibition of placental estrone_sulfatase and aromatase enzymes by vitamin_D3 and its analogs .
8360493	0	vitamin_D3	14,24	group-specific_component	42,66	vitamin D3	group-specific component	MESH:D002762	14473(Tax:10090)	Chemical	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Conversion of vitamin_D3 binding protein -LRB- group-specific_component -RRB- to a macrophage activating factor by the stepwise action of beta-galactosidase of B cells and sialidase of T cells .
22251138	0	vitamin_D3	11,21	growth-related_oncogene-a	43,68	vitamin D3	growth-related oncogene-a	MESH:D002762	2919	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effects of vitamin_D3 on the expression of growth-related_oncogene-a in THP-1 cells and human primary monocytes .
3257676	0	vitamin_D3	68,78	interleukin-2	93,106	vitamin D3	interleukin-2	MESH:D002762	3558	Chemical	Gene	START_ENTITY|acl|inhibiting inhibiting|dobj|production production|compound|END_ENTITY	Biological activity of 26,26,26,27,27,27-hexafluorinated analogs of vitamin_D3 in inhibiting interleukin-2 production by peripheral blood mononuclear cells stimulated by phytohemagglutinin .
7565732	0	vitamin_D3	56,66	interleukin-2	34,47	vitamin D3	interleukin-2	MESH:D002762	3558	Chemical	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Transcriptional repression of the interleukin-2 gene by vitamin_D3 : direct inhibition of NFATp/AP -1 complex formation by a nuclear hormone receptor .
9578149	0	vitamin_D3	10,20	interleukin-6	24,37	vitamin D3	interleukin-6	MESH:D002762	16193(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|synthesis synthesis|amod|END_ENTITY	Effect of vitamin_D3 on interleukin-6 synthesis induced by prostaglandins in osteoblasts .
8224758	0	vitamin_D3	42,52	intestinal_alkaline_phosphatase	80,111	vitamin D3	intestinal alkaline phosphatase	MESH:D002762	248	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of estrogen in relation to dietary vitamin_D3 and calcium on activity of intestinal_alkaline_phosphatase and Ca-ATPase in immature chicks .
12371967	0	vitamin_D3	78,88	megalin	61,68	vitamin D3	megalin	MESH:D002762	14725(Tax:10090)	Chemical	Gene	metabolism|amod|START_ENTITY END_ENTITY|nmod|metabolism	Expression profiling confirms the role of endocytic receptor megalin in renal vitamin_D3 metabolism .
15707954	0	vitamin_D3	66,76	parathyroid_hormone	29,48	vitamin D3	parathyroid hormone	MESH:D002762	5741	Chemical	Gene	promoter|nmod|START_ENTITY promoter|amod|END_ENTITY	Negative regulation of human parathyroid_hormone gene promoter by vitamin_D3 through nuclear factor Y .
7671162	0	vitamin_D3	49,59	parathyroid_hormone	13,32	vitamin D3	parathyroid hormone	MESH:D002762	5741	Chemical	Gene	treatment|amod|START_ENTITY secretion|nmod|treatment secretion|amod|END_ENTITY	Resetting of parathyroid_hormone secretion after vitamin_D3 treatment in hypoparathyroidism and after parathyroid adenectomy in primary_hyperparathyroidism .
11702003	0	vitamin_D3	68,78	stanniocalcin_1	16,31	vitamin D3	stanniocalcin 1	MESH:D002762	81801(Tax:10116)	Chemical	Gene	Distribution|nmod|START_ENTITY Distribution|nmod|END_ENTITY	Distribution of stanniocalcin_1 in rat kidney and its regulation by vitamin_D3 .
1895752	0	vitamin_D3	14,24	transforming_growth_factor_beta	94,125	vitamin D3	transforming growth factor beta	MESH:D002762	7040	Chemical	Gene	Inhibition|nmod|START_ENTITY induced|nsubj|Inhibition induced|nmod|END_ENTITY	Inhibition by vitamin_D3 of erythroid differentiation of human leukemia line cells induced by transforming_growth_factor_beta or erythroid_differentiation_factor -LRB- activin A -RRB- .
1800316	0	vitamin_D3	18,28	tumor_necrosis_factor-alpha	84,111	vitamin D3	tumor necrosis factor-alpha	MESH:D002762	7124	Chemical	Gene	22-oxacalcitriol|amod|START_ENTITY suppresses|nsubj|22-oxacalcitriol suppresses|dobj|production production|nmod|END_ENTITY	The weak calcemic vitamin_D3 analogue 22-oxacalcitriol suppresses the production of tumor_necrosis_factor-alpha by peripheral mononuclear cells .
20722932	0	vitamin_D3	11,21	tumor_necrosis_factor-alpha	39,66	vitamin D3	tumor necrosis factor-alpha	MESH:D002762	7124	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of vitamin_D3 on expression of tumor_necrosis_factor-alpha and chemokines by monocytes .
16141393	0	vitamin_D_sterol	36,52	heat_shock_protein-70	64,85	vitamin D sterol	heat shock protein-70	null	3312	Chemical	Gene	START_ENTITY|nmod|chaperones chaperones|amod|END_ENTITY	Adenosine_5 ' - triphosphate-dependent vitamin_D_sterol binding to heat_shock_protein-70 chaperones .
2508746	0	vitamin_E	19,28	5-lipoxygenase	52,66	vitamin E	5-lipoxygenase	MESH:D014810	25290(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|biosynthesis biosynthesis|nmod|products products|amod|END_ENTITY	Effects of dietary vitamin_E on the biosynthesis of 5-lipoxygenase products by rat polymorphonuclear leukocytes -LRB- PMNL -RRB- .
3934003	0	vitamin_E	32,41	5-lipoxygenase	14,28	vitamin E	5-lipoxygenase	MESH:D014810	102577615	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of 5-lipoxygenase by vitamin_E .
21179780	0	vitamin_E	12,21	Abeta	62,67	vitamin E	Abeta	MESH:D014810	54226(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of vitamin_E on expression of PS-1 and production of Abeta in the hippocampus of female senile rats -RSB- .
22387694	5	vitamin_E	915,924	Abeta	1005,1010	vitamin E	Abeta	MESH:D014810	351	Chemical	Gene	prevented|nsubj|START_ENTITY prevented|advcl|applied applied|nmod|END_ENTITY	Both vitamin_E and NAC prevented Abeta-induced ROS generation when applied simultaneously with Abeta , but only NAC prevented Abeta-induced ROS generation when added to cultures that had previously been exposed to Abeta .
601790	0	vitamin_E	62,71	CCl4	102,106	vitamin E	CCl4	MESH:D014810	6351	Chemical	Gene	changes|amod|START_ENTITY changes|nmod|END_ENTITY	Lipid peroxidation and the concept of antioxygenic potential : vitamin_E changes in acute experimental CCl4 - , BrCCl3 - , and ethanol-induced liver_injury .
25174330	0	vitamin_E	41,50	CD36	24,28	vitamin E	CD36	MESH:D014810	12491(Tax:10090)	Chemical	Gene	response|amod|START_ENTITY impacts|nmod|response impacts|nsubj|Cluster-determinant Cluster-determinant|appos|END_ENTITY	Cluster-determinant 36 -LRB- CD36 -RRB- impacts on vitamin_E postprandial response .
7277852	0	vitamin_E	26,35	CS2	66,69	vitamin E	CS2	MESH:D014810	171394(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|effects effects|nmod|END_ENTITY	-LSB- The protective effect of vitamin_E on the hepatotoxic effects of CS2 in male albino rats of Wistar_strain -LRB- author 's transl -RRB- -RSB- .
14968931	0	vitamin_E	46,55	GPx1	114,118	vitamin E	GPx1	MESH:D014810	100009258(Tax:9986)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effect of increasing selenite concentrations , vitamin_E supplementation and different fetal calf serum content on GPx1 activity in primary cultured rabbit hepatocytes .
8886791	0	vitamin_E	10,19	GSH-PX1	53,60	vitamin E	GSH-PX1	MESH:D014810	2876	Chemical	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Effect of vitamin_E on human glutathione peroxidase -LRB- GSH-PX1 -RRB- expression in cardiomyocytes .
9018482	0	vitamin_E	10,19	HSP70	70,75	vitamin E	HSP70	MESH:D014810	266759(Tax:10116)	Chemical	Gene	deprivation|amod|START_ENTITY Effect|nmod|deprivation Effect|nmod|END_ENTITY	Effect of vitamin_E deprivation and exercise training on induction of HSP70 .
10414937	0	vitamin_E	46,55	Insulin	0,7	vitamin E	Insulin	MESH:D014810	3630	Chemical	Gene	influenced|nmod|START_ENTITY influenced|nsubj|action action|compound|END_ENTITY	Insulin action and fibrinolysis influenced by vitamin_E in obese_Type_2_diabetes_mellitus .
10609875	0	vitamin_E	10,19	MIF	77,80	vitamin E	MIF	MESH:D014810	81683(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of vitamin_E on production of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- by macrophages .
16530159	0	vitamin_E	63,72	PPARgamma	47,56	vitamin E	PPARgamma	MESH:D014810	5468	Chemical	Gene	treatment|amod|START_ENTITY END_ENTITY|nmod|treatment	Increased expression of transglutaminase-1 and PPARgamma after vitamin_E treatment in human keratinocytes .
21179780	0	vitamin_E	12,21	PS-1	39,43	vitamin E	PS-1	MESH:D014810	29192(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of vitamin_E on expression of PS-1 and production of Abeta in the hippocampus of female senile rats -RSB- .
22444044	0	vitamin_E	14,23	PUFA	138,142	vitamin E	PUFA	MESH:D014810	100326836(Tax:9823)	Chemical	Gene	mixture|amod|START_ENTITY effect|nmod|mixture effect|acl|induced induced|nmod|load load|compound|END_ENTITY	The effect of vitamin_E and plant_extract mixture composed of carvacrol , cinnamaldehyde and capsaicin on oxidative stress induced by high PUFA load in young pigs .
7195802	0	vitamin_E	8,17	PUFA	50,54	vitamin E	PUFA	MESH:D014810	100531402	Chemical	Gene	Dietary|amod|START_ENTITY Dietary|appos|END_ENTITY	Dietary vitamin_E and polyunsaturated_fatty_acid -LRB- PUFA -RRB- in newborn babies with physiological jaundice .
16380385	0	vitamin_E	57,66	Scavenger_receptor_class_B_type_I	0,33	vitamin E	Scavenger receptor class B type I	MESH:D014810	20778(Tax:10090)	Chemical	Gene	transport|amod|START_ENTITY involved|nmod|transport involved|nsubjpass|END_ENTITY	Scavenger_receptor_class_B_type_I -LRB- SR-BI -RRB- is involved in vitamin_E transport across the enterocyte .
11814146	0	vitamin_E	29,38	acetylcholinesterase	62,82	vitamin E	acetylcholinesterase	MESH:D014810	83817(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|compound|END_ENTITY	Effect of supplementation of vitamin_E and vitamin_C on brain acetylcholinesterase activity and neurotransmitter levels in rats treated with scopolamine , an inducer of dementia .
7160966	0	vitamin_E	18,27	aryl_hydrocarbon_hydroxylase	35,63	vitamin E	aryl hydrocarbon hydroxylase	MESH:D014810	24296(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effect of dietary vitamin_E on the aryl_hydrocarbon_hydroxylase activity of various tissues in rat .
19024988	0	vitamin_E	14,23	basic_fibroblast_growth_factor	27,57	vitamin E	basic fibroblast growth factor	MESH:D014810	2247	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|level level|compound|END_ENTITY	The effect of vitamin_E on basic_fibroblast_growth_factor level in human fibroblast cell culture .
16102431	0	vitamin_E	15,24	calcineurin_inhibitor	42,63	vitamin E	calcineurin inhibitor	MESH:D014810	23523	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|compound|END_ENTITY	Effect of oral vitamin_E and C therapy on calcineurin_inhibitor levels in heart transplant recipients .
19540377	0	vitamin_E	58,67	cholesteryl_ester_transfer_protein	10,44	vitamin E	cholesteryl ester transfer protein	MESH:D014810	1071	Chemical	Gene	transport|amod|START_ENTITY inhibitor|nmod|transport inhibitor|compound|END_ENTITY	Effect of cholesteryl_ester_transfer_protein inhibitor on vitamin_E transport should be studied .
9710685	0	vitamin_E	11,20	cholesteryl_ester_transfer_protein	57,91	vitamin E	cholesteryl ester transfer protein	MESH:D014810	1071	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	Effects of vitamin_E and HMG-CoA reductase inhibition on cholesteryl_ester_transfer_protein and lecithin-cholesterol_acyltransferase in hypercholesterolemia .
11121721	0	vitamin_E	57,66	cyclooxygenase-2	26,42	vitamin E	cyclooxygenase-2	MESH:D014810	5743	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|expression expression|amod|END_ENTITY	Synergistic inhibition of cyclooxygenase-2 expression by vitamin_E and aspirin .
8954137	0	vitamin_E	10,19	cyclooxygenase-2	37,53	vitamin E	cyclooxygenase-2	MESH:D014810	29527(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of vitamin_E on expression of cyclooxygenase-2 in lipopolysaccharide-stimulated rat macrophages .
4075438	0	vitamin_E	18,27	cytochrome_P-450	81,97	vitamin E	cytochrome P-450	MESH:D014810	25251(Tax:10116)	Chemical	Gene	START_ENTITY|xcomp|microsomal microsomal|dobj|peroxidase peroxidase|amod|END_ENTITY	Effect of dietary vitamin_E on methyl_ethyl_ketone_peroxide damage to microsomal cytochrome_P-450 peroxidase .
9795969	0	vitamin_E	10,19	cytochrome_P-450	35,51	vitamin E	cytochrome P-450	MESH:D014810	25251(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	Effect of vitamin_E on rat hepatic cytochrome_P-450 activity .
121247	0	vitamin_E	29,38	cytochrome_P_450	89,105	vitamin E	cytochrome P 450	MESH:D014810	25251(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of alpha-tocopherol -LRB- vitamin_E -RRB- on the utilization of vitamin_A and induction of cytochrome_P_450 in rats receiving DDT -RSB- .
22349	0	vitamin_E	35,44	delta9-desaturase	52,69	vitamin E	delta9-desaturase	MESH:D014810	280924(Tax:9913)	Chemical	Gene	START_ENTITY|nmod|activities activities|amod|END_ENTITY	Effects of dietary vitamin_B-2 and vitamin_E on the delta9-desaturase and catalase activities in the rat liver microsomes .
22061299	0	vitamin_E	22,31	drip_loss	51,60	vitamin E	drip loss	MESH:D014810	100885434	Chemical	Gene	supplementation|amod|START_ENTITY supplementation|nmod|END_ENTITY	The effect of dietary vitamin_E supplementation on drip_loss of bovine Longissimus lumborum , psoas major and Semitendinosus muscles .
22528588	0	vitamin_E	17,26	erythropoietin	46,60	vitamin E	erythropoietin	MESH:D014810	2056	Chemical	Gene	supplementation|amod|START_ENTITY supplementation|nmod|END_ENTITY	The influence of vitamin_E supplementation on erythropoietin responsiveness in chronic hemodialysis patients with low levels of erythrocyte superoxide dismutase .
3958828	0	vitamin_E	44,53	glucose-6-phosphate_dehydrogenase	92,125	vitamin E	glucose-6-phosphate dehydrogenase	MESH:D014810	2539	Chemical	Gene	START_ENTITY|nmod|children children|nmod|deficiency deficiency|amod|END_ENTITY	Improved erythrocyte survival with combined vitamin_E and selenium therapy in children with glucose-6-phosphate_dehydrogenase deficiency and mild chronic hemolysis .
18269637	0	vitamin_E	19,28	insulin	44,51	vitamin E	insulin	MESH:D014810	3630	Chemical	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Plasma and dietary vitamin_E in relation to insulin secretion and sensitivity .
22532269	0	vitamin_E	130,139	insulin	36,43	vitamin E	insulin	MESH:D014810	3630	Chemical	Gene	pioglitazone|nmod|START_ENTITY Relationship|dep|pioglitazone Relationship|nmod|resistance resistance|compound|END_ENTITY	Relationship between adipose tissue insulin resistance and liver histology in nonalcoholic_steatohepatitis : a pioglitazone versus vitamin_E versus placebo for the treatment of nondiabetic patients with nonalcoholic_steatohepatitis trial follow-up study .
16581113	0	vitamin_E	63,72	interferon-alpha_2b	24,43	vitamin E	interferon-alpha 2b	MESH:D014810	3440	Chemical	Gene	combined|nmod|START_ENTITY combined|nsubj|Effect Effect|nmod|END_ENTITY	Effect of intralesional interferon-alpha_2b combined with oral vitamin_E for treatment of early stage Peyronie 's _ disease : a randomized and prospective study .
16445440	0	vitamin_E	27,36	leptin	65,71	vitamin E	leptin	MESH:D014810	100716751	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of intraperitoneal vitamin_E , melatonin and aprotinin on leptin expression in the guinea_pig eye during experimental uveitis .
24622827	0	vitamin_E	34,43	leptin	55,61	vitamin E	leptin	MESH:D014810	25608(Tax:10116)	Chemical	Gene	supplementation|nmod|START_ENTITY influences|nsubj|supplementation influences|dobj|expression expression|compound|END_ENTITY	Time-dependent supplementation of vitamin_E influences leptin expression in the aortic layers of rats fed atherogenic diet .
10609875	0	vitamin_E	10,19	macrophage_migration_inhibitory_factor	37,75	vitamin E	macrophage migration inhibitory factor	MESH:D014810	103694877	Chemical	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	Effect of vitamin_E on production of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- by macrophages .
9739171	0	vitamin_E	83,92	macrophage_migration_inhibitory_factor	14,52	vitamin E	macrophage migration inhibitory factor	MESH:D014810	103694877	Chemical	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of macrophage_migration_inhibitory_factor secretion from macrophages by vitamin_E .
12919641	0	vitamin_E	11,20	myosin_light_chain_kinase	24,49	vitamin E	myosin light chain kinase	MESH:D014810	100009143(Tax:9986)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	-LSB- Effect of vitamin_E on myosin_light_chain_kinase activity and endothelial permeability of the artery in atherosclerotic rabbit -RSB- .
25061569	0	vitamin_E	112,121	p38	77,80	vitamin E	p38	MESH:D014810	26416(Tax:10090)	Chemical	Gene	role|nmod|START_ENTITY activation|dep|role activation|amod|END_ENTITY	Ab and tau toxicities in Alzheimer 's are linked via oxidative stress-induced p38 activation : protective role of vitamin_E .
17388862	0	vitamin_E	11,20	peroxisome_proliferator-activated_receptor-alpha	34,82	vitamin E	peroxisome proliferator-activated receptor-alpha	MESH:D014810	5465	Chemical	Gene	treatment|amod|START_ENTITY treatment|nmod|expression expression|amod|END_ENTITY	Effects of vitamin_E treatment on peroxisome_proliferator-activated_receptor-alpha expression and insulin resistance in patients with non-alcoholic_steatohepatitis : results of a pilot study .
15448094	0	vitamin_E	22,31	phospholipid_transfer_protein	94,123	vitamin E	phospholipid transfer protein	MESH:D014810	5360	Chemical	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Alterations in plasma vitamin_E distribution in type 2 diabetic patients with elevated plasma phospholipid_transfer_protein activity .
17949955	0	vitamin_E	25,34	plasminogen_activator_inhibitor_type_1	54,92	vitamin E	plasminogen activator inhibitor type 1	MESH:D014810	5054	Chemical	Gene	supplementation|amod|START_ENTITY supplementation|nmod|END_ENTITY	A study on the action of vitamin_E supplementation on plasminogen_activator_inhibitor_type_1 and platelet nitric_oxide production in type 2 diabetic patients .
7282596	0	vitamin_E	10,19	prothrombin	23,34	vitamin E	prothrombin	MESH:D014810	2147	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|compound|END_ENTITY	Effect of vitamin_E on prothrombin levels in warfarin-induced vitamin_K deficiency .
21265240	0	vitamin_E	11,20	receptor_activator_of_nuclear_factor_kappa_B_ligand	24,75	vitamin E	receptor activator of nuclear factor kappa B ligand	MESH:D014810	117516(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of vitamin_E on receptor_activator_of_nuclear_factor_kappa_B_ligand -LRB- RANKL -RRB- and osteoprotegerin -LRB- OPG -RRB- in rats treated with nicotine .
2634036	0	vitamin_E	11,20	retinol_binding_protein	22,45	vitamin E	retinol binding protein	MESH:D014810	5950	Chemical	Gene	Vitamin_A|appos|START_ENTITY Vitamin_A|appos|END_ENTITY	Vitamin_A , vitamin_E , retinol_binding_protein -LRB- RBP -RRB- , and prealbumin in digestive_cancers .
20028458	0	vitamin_E_alpha-tocotrienol	10,37	phospholipase_A2	79,95	vitamin E alpha-tocotrienol	phospholipase A2	null	151056	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|END_ENTITY	Nanomolar vitamin_E_alpha-tocotrienol inhibits glutamate-induced activation of phospholipase_A2 and causes neuroprotection .
43733	0	vitamin_K	84,93	catalase	24,32	vitamin K	catalase	MESH:D014812	847	Chemical	Gene	analog|compound|START_ENTITY END_ENTITY|nmod|analog	Restoration of red cell catalase activity by glucose metabolism after exposure to a vitamin_K analog .
1492386	0	vitamin_K	104,113	cytochrome_B5	46,59	vitamin K	cytochrome B5	MESH:D014812	64001(Tax:10116)	Chemical	Gene	Activity|nmod|START_ENTITY Activity|nmod|END_ENTITY	-LSB- Activity of menadione_reductase and level of cytochrome_B5 and P-450 in liver with varying supplies of vitamin_K and administration of pelentan to rats -RSB- .
20211293	0	vitamin_K	72,81	factor_Xa	37,46	vitamin K	factor Xa	MESH:D014812	2159	Chemical	Gene	antagonism|compound|START_ENTITY inhibition|nmod|antagonism inhibition|compound|END_ENTITY	Rivaroxaban-once daily , oral , direct factor_Xa inhibition compared with vitamin_K antagonism for prevention of stroke and Embolism Trial in Atrial_Fibrillation : rationale and design of the ROCKET AF study .
24315894	0	vitamin_K	152,161	factor_Xa	117,126	vitamin K	factor Xa	MESH:D014812	2159	Chemical	Gene	antagonism|compound|START_ENTITY inhibition|nmod|antagonism inhibition|compound|END_ENTITY	Factors associated with major_bleeding events : insights from the ROCKET AF trial -LRB- rivaroxaban once-daily oral direct factor_Xa inhibition compared with vitamin_K antagonism for prevention of stroke and embolism trial in atrial_fibrillation -RRB- .
1492386	0	vitamin_K	104,113	menadione_reductase	13,32	vitamin K	menadione reductase	MESH:D014812	24314(Tax:10116)	Chemical	Gene	Activity|nmod|START_ENTITY Activity|nmod|END_ENTITY	-LSB- Activity of menadione_reductase and level of cytochrome_B5 and P-450 in liver with varying supplies of vitamin_K and administration of pelentan to rats -RSB- .
989196	0	vitamin_K	47,56	prothrombin	86,97	vitamin K	prothrombin	MESH:D014812	2147	Chemical	Gene	Isolation|nmod|START_ENTITY Isolation|nmod|END_ENTITY	Isolation of preliminary characterization of a vitamin_K dependent peptide from human prothrombin .
19572066	0	vitamin_K	50,59	thrombin	27,35	vitamin K	thrombin	MESH:D014812	2147	Chemical	Gene	generation|nmod|START_ENTITY generation|compound|END_ENTITY	Differential inhibition of thrombin generation by vitamin_K antagonists alone and associated with low-molecular-weight heparin .
21561094	0	vitamin_K2	19,29	SXR	161,164	vitamin K2	SXR	MESH:D024482	8856	Chemical	Gene	analogues|amod|START_ENTITY Synthesis|nmod|analogues Synthesis|appos|END_ENTITY	Synthesis of novel vitamin_K2 analogues with modification at the - terminal position and their biological evaluation as potent steroid_and_xenobiotic_receptor -LRB- SXR -RRB- agonists .
18095058	0	vitamin_K2	49,59	Steroid_and_xenobiotic_receptor	0,31	vitamin K2	Steroid and xenobiotic receptor	MESH:D024482	8856	Chemical	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	Steroid_and_xenobiotic_receptor mediates a novel vitamin_K2 signaling pathway in osteoblastic cells .
15003806	0	vitamin_K2	11,21	parathyroid_hormone	62,81	vitamin K2	parathyroid hormone	MESH:D024482	5741	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|compound|END_ENTITY	Effects of vitamin_K2 in hemodialysis patients with low serum parathyroid_hormone levels .
6682115	0	vitamin_a	74,83	retinol-binding_protein	108,131	vitamin a	retinol-binding protein	MESH:D014801	25703(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|nmod|END_ENTITY	Ligand-dependent regulation of intracellular protein transport : effect of vitamin_a on the secretion of the retinol-binding_protein .
18475933	0	vitamin_d	8,17	gastrin	39,46	vitamin d	gastrin	MESH:D014807	25320(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|production production|compound|END_ENTITY	Role of vitamin_d on the inhibition of gastrin production after Cisplatin treatment .
23607098	0	vitamin_d	25,34	osteocalcin	83,94	vitamin d	osteocalcin	MESH:D014807	12097(Tax:10090)	Chemical	Gene	function|amod|START_ENTITY determination|nmod|function using|nsubj|determination luciferase|advcl|using luciferase|nsubj|END_ENTITY	In vivo determination of vitamin_d function using transgenic_mice carrying a human osteocalcin luciferase reporter gene .
16439822	0	vitamin_d	37,46	parathyroid_hormone	85,104	vitamin d	parathyroid hormone	MESH:D014807	5741	Chemical	Gene	levels|nmod|START_ENTITY variance|nmod|levels determines|nsubj|variance determines|nmod|END_ENTITY	Seasonal variance in serum levels of vitamin_d determines a compensatory response by parathyroid_hormone : study in an ambulatory elderly population in Quebec .
176830	0	vitamin_d	142,151	parathyroid_hormone	55,74	vitamin d	parathyroid hormone	MESH:D014807	5741	Chemical	Gene	-RSB-|amod|START_ENTITY excretion|nmod|-RSB- investigations|acl|excretion investigations|nmod|level level|compound|END_ENTITY	-LSB- Pseudohypoparathyroidism : investigations of the serum parathyroid_hormone level , pte resistance and urinary camp excretion before and during vitamin_d treatment -LRB- author 's transl -RRB- -RSB- .
19116262	0	vitamin_d2	14,24	cytochrome_p450scc	61,79	vitamin d2	cytochrome p450scc	MESH:D004872	1583	Chemical	Gene	Metabolism|nmod|START_ENTITY Metabolism|nmod|END_ENTITY	Metabolism of vitamin_d2 to 17,20,24-trihydroxyvitamin _ d2 by cytochrome_p450scc -LRB- CYP11A1 -RRB- .
20209470	0	vitamins	16,24	lactoperoxidase	28,43	vitamins	lactoperoxidase	CHEBI:33229	280844(Tax:9913)	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effects of some vitamins on lactoperoxidase enzyme activity .
23279831	0	vitamins_C	23,33	myeloperoxidase	93,108	vitamins C	myeloperoxidase	null	4353	Chemical	Gene	effects|nmod|START_ENTITY mediated|nsubj|effects mediated|nmod|END_ENTITY	Antioxidant effects of vitamins_C and e on the low-density lipoprotein oxidation mediated by myeloperoxidase .
26313310	0	vitamins_C_and_E	10,26	insulin	30,37	vitamins C and E	insulin	null	3630	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	Effect of vitamins_C_and_E on insulin resistance in diabetes : a meta-analysis study .
11724297	0	vitamins_K1	22,33	K2_and_K3	35,44	vitamins K1	K2 and K3	null	58164	Chemical	Gene	activity|nmod|START_ENTITY activity|appos|END_ENTITY	Cytotoxic activity of vitamins_K1 , K2_and_K3 against human oral_tumor cell lines .
22782262	0	vizottin	31,39	factor_Xa	51,60	vizottin	factor Xa	null	2159	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Functional characterisation of vizottin , the first factor_Xa inhibitor purified from the leech Haementeria vizottoi .
24330024	0	voclosporin	66,77	P-glycoprotein	23,37	voclosporin	P-glycoprotein	MESH:C484071	5243	Chemical	Gene	interactions|nmod|START_ENTITY interactions|amod|END_ENTITY	Cytochrome P450 3A and P-glycoprotein drug-drug interactions with voclosporin .
25794535	0	volasertib	17,27	Polo-like_kinase	31,47	volasertib	Polo-like kinase	null	5347	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Phase I trial of volasertib , a Polo-like_kinase inhibitor , plus platinum agents in solid_tumors : safety , pharmacokinetics and activity .
12649040	0	vomitoxin	56,65	Cyclooxygenase-2	0,16	vomitoxin	Cyclooxygenase-2	MESH:C007262	19225(Tax:10090)	Chemical	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Cyclooxygenase-2 mediates interleukin-6 upregulation by vomitoxin -LRB- deoxynivalenol -RRB- in vitro and in vivo .
9439728	0	vomitoxin	42,51	IL-2	18,22	vomitoxin	IL-2	MESH:C007262	16183(Tax:10090)	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Superinduction of IL-2 gene expression by vomitoxin -LRB- deoxynivalenol -RRB- involves increased mRNA stability .
8887449	0	vomitoxin	11,20	NF-kappa_B	62,72	vomitoxin	NF-kappa B	MESH:C007262	18033(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of vomitoxin -LRB- deoxynivalenol -RRB- on transcription factor NF-kappa_B / Rel binding activity in murine EL-4_thymoma and primary CD4 + T cells .
20002085	0	voriconazole	82,94	CYP2C19	110,117	voriconazole	CYP2C19	MESH:C102790	1557	Chemical	Gene	START_ENTITY|nmod|genotype genotype|compound|END_ENTITY	Pharmacokinetics , metabolism and bioavailability of the triazole antifungal agent voriconazole in relation to CYP2C19 genotype .
24510446	0	voriconazole	57,69	CYP2C19	0,7	voriconazole	CYP2C19	MESH:C102790	1557	Chemical	Gene	polymorphisms|nmod|START_ENTITY polymorphisms|nummod|END_ENTITY	CYP2C19 polymorphisms and therapeutic drug monitoring of voriconazole : are we ready for clinical implementation of pharmacogenomics ?
16940139	0	voriconazole	10,22	CYP2C9	41,47	voriconazole	CYP2C9	MESH:C102790	1559	Chemical	Gene	START_ENTITY|nmod|patient patient|nmod|END_ENTITY	Safety of voriconazole in a patient with CYP2C9 * 2/CYP2C9 * 2 genotype .
24491555	0	voriconazole	76,88	CYP46A1	53,60	voriconazole	CYP46A1	MESH:C102790	362782(Tax:10116)	Chemical	Gene	inhibition|nmod|START_ENTITY inhibition|appos|END_ENTITY	In vivo consequences of cholesterol-24S-hydroxylase -LRB- CYP46A1 -RRB- inhibition by voriconazole on cholesterol homeostasis and function in the rat retina .
16890574	0	voriconazole	65,77	cytochrome_P450_2C19	7,27	voriconazole	cytochrome P450 2C19	MESH:C102790	1557	Chemical	Gene	interaction|nmod|START_ENTITY interaction|amod|END_ENTITY	Potent cytochrome_P450_2C19 genotype-related interaction between voriconazole and the cytochrome P450 3A4 inhibitor ritonavir .
23590726	0	vorinostat	17,27	CHOP	57,61	vorinostat	CHOP	MESH:C111237	1649	Chemical	Gene	study|nmod|START_ENTITY END_ENTITY|nsubj|study	Phase I study of vorinostat in combination with standard CHOP in patients with newly diagnosed peripheral_T-cell_lymphoma .
24636848	0	vorinostat	20,30	EGFR	139,143	vorinostat	EGFR	MESH:C111237	1956	Chemical	Gene	mutations|amod|START_ENTITY mutations|appos|END_ENTITY	Phase I/II trial of vorinostat -LRB- SAHA -RRB- and erlotinib for non-small_cell_lung_cancer -LRB- NSCLC -RRB- patients with epidermal_growth_factor_receptor -LRB- EGFR -RRB- mutations after erlotinib progression .
19322073	0	vorinostat	9,19	HDAC	85,89	vorinostat	HDAC	MESH:C111237	9734	Chemical	Gene	resistance|compound|START_ENTITY shows|nsubj|resistance shows|nmod|inhibitors inhibitors|compound|END_ENTITY	Acquired vorinostat resistance shows partial cross-resistance to ` second-generation ' HDAC inhibitors and correlates with loss of histone acetylation and apoptosis but not with altered HDAC and HAT activities .
24416160	0	vorinostat	137,147	HDAC	121,125	vorinostat	HDAC	MESH:C111237	9734	Chemical	Gene	START_ENTITY|nmod|combination combination|nmod|inhibitor inhibitor|compound|END_ENTITY	Evaluation of the antitumor effects of BPR1J-340 , a potent and selective FLT3 inhibitor , alone or in combination with an HDAC inhibitor , vorinostat , in AML_cancer .
21198545	0	vorinostat	35,45	IL-10	74,79	vorinostat	IL-10	MESH:C111237	3586	Chemical	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	The histone deacetylase inhibitors vorinostat and romidepsin downmodulate IL-10 expression in cutaneous_T-cell_lymphoma cells .
23758082	0	vorinostat	20,30	MK-0683	32,39	vorinostat	MK-0683	MESH:C111237	1476784(Tax:190192)	Chemical	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	A phase II study of vorinostat -LRB- MK-0683 -RRB- in patients with polycythaemia vera and essential thrombocythaemia .
24425692	0	vorinostat	20,30	MK-0683	32,39	vorinostat	MK-0683	MESH:C111237	1476784(Tax:190192)	Chemical	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	A phase II study of vorinostat -LRB- MK-0683 -RRB- in patients with primary myelofibrosis and post-polycythemia vera myelofibrosis .
22506596	0	vorinostat	76,86	histone_deacetylase	46,65	vorinostat	histone deacetylase	MESH:C111237	9734	Chemical	Gene	START_ENTITY|nsubj|I I|nmod|inhibitor inhibitor|compound|END_ENTITY	Phase I and pharmacokinetic study of the oral histone_deacetylase inhibitor vorinostat in Japanese patients with relapsed or refractory cutaneous_T-cell_lymphoma .
26635974	5	vorozole	786,794	CYP1A1	820,826	vorozole	CYP2A6	MESH:C060523	1548	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	It was determined that vorozole is a potent inhibitor of CYP1A1 -LRB- IC50 = 0.469 M -RRB- and a moderate inhibitor of CYP2A6 and CYP3A4 -LRB- IC50 = 24.4 and 98.1 M , resp . -RRB- .
26253622	0	vortioxetine	56,68	Part_1	92,98	vortioxetine	Part 1	null	25859	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|END_ENTITY	Differentiated effects of the multimodal antidepressant vortioxetine on sleep architecture : Part_1 , a pharmacokinetic/pharmacodynamic comparison with paroxetine in healthy men .
19899329	0	warfarin	64,72	CYP2C9	0,6	warfarin	CYP2C9	MESH:D014859	1559	Chemical	Gene	analysis|nmod|START_ENTITY analysis|compound|END_ENTITY	CYP2C9 gene analysis of some Iranian hypersensitive patients to warfarin .
21148049	0	warfarin	48,56	CYP2C9	13,19	warfarin	CYP2C9	MESH:D014859	1559	Chemical	Gene	polymorphisms|nmod|START_ENTITY polymorphisms|nsubj|Influence Influence|nmod|END_ENTITY	Influence of CYP2C9 and VKORC1 polymorphisms on warfarin and acenocoumarol in a sample of Lebanese people .
22071881	0	warfarin	65,73	CYP2C9	92,98	warfarin	CYP2C9	MESH:D014859	1559	Chemical	Gene	sensitivity|compound|START_ENTITY sensitivity|nmod|END_ENTITY	Factor VII R353Q genetic polymorphism is associated with altered warfarin sensitivity among CYP2C9 * 1 / * 1 carriers .
25246753	0	warfarin	53,61	CYP2C9	80,86	warfarin	CYP2C9	MESH:D014859	1559	Chemical	Gene	START_ENTITY|nmod|patient patient|nmod|END_ENTITY	Extremely elevated international normalized ratio of warfarin in a patient with CYP2C9 * 1 / * 3 and thyrotoxicosis .
25699611	0	warfarin	55,63	CYP2C9	10,16	warfarin	CYP2C9	MESH:D014859	1559	Chemical	Gene	requirements|amod|START_ENTITY polymorphisms|nmod|requirements polymorphisms|nsubj|Impact Impact|nmod|END_ENTITY	Impact of CYP2C9 and VKORC1 genetic polymorphisms upon warfarin dose requirements in Egyptian patients with acute_coronary_syndrome .
9352571	0	warfarin	43,51	CYP2C9	70,76	warfarin	CYP2C9	MESH:D014859	1559	Chemical	Gene	association|nmod|START_ENTITY association|nmod|END_ENTITY	Genetic association between sensitivity to warfarin and expression of CYP2C9 * 3 .
23391196	0	warfarin	52,60	Factor_Xa	183,192	warfarin	Factor Xa	MESH:D014859	2159	Chemical	Gene	START_ENTITY|dep|Inhibition Inhibition|compound|END_ENTITY	Outcomes of discontinuing rivaroxaban compared with warfarin in patients with nonvalvular atrial_fibrillation : analysis from the ROCKET AF trial -LRB- Rivaroxaban Once-Daily , Oral , Direct Factor_Xa Inhibition Compared With Vitamin_K Antagonism for Prevention of Stroke and Embolism Trial in Atrial_Fibrillation -RRB- .
24643605	0	warfarin	24,32	Factor_Xa	0,9	warfarin	Factor Xa	MESH:D014859	2159	Chemical	Gene	inhibitors|dobj|START_ENTITY inhibitors|nsubj|END_ENTITY	Factor_Xa inhibitors vs warfarin for preventing stroke and thromboembolism in patients with atrial_fibrillation .
22793260	0	warfarin	5,13	IL-6	49,53	warfarin	IL-6	MESH:D014859	24498(Tax:10116)	Chemical	Gene	affects|nsubj|START_ENTITY affects|dobj|END_ENTITY	Oral warfarin affects peripheral blood leukocyte IL-6 and TNFa production in rats .
24338960	0	warfarin	16,24	P2Y12	34,39	warfarin	P2Y12	MESH:D014859	64805	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Combined use of warfarin and oral P2Y12 inhibitors in patients with atrial_fibrillation and acute_coronary_syndrome .
23413520	1	warfarin	78,86	VKORC1	19,25	warfarin	VKORC1	MESH:D014859	79001	Chemical	Gene	analysis|nmod|START_ENTITY analysis|compound|END_ENTITY	VKORC1 gene analysis of some Iranian sensitive patients to warfarin .
16222368	0	warfarin	51,59	albumin	98,105	warfarin	albumin	MESH:D014859	213	Chemical	Gene	binding|nmod|START_ENTITY END_ENTITY|amod|binding	QCM/HCC as a platform for detecting the binding of warfarin to an immobilized film of human serum albumin .
4062432	0	warfarin	11,19	albumin	29,36	warfarin	albumin	MESH:D014859	213	Chemical	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of warfarin by human albumin in the presence of a perfluorochemical blood substitute .
3981543	0	warfarin	58,66	cytochrome_P-450	100,116	warfarin	cytochrome P-450	MESH:D014859	25251(Tax:10116)	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|nmod|END_ENTITY	Stereoselective metabolism of conformational analogues of warfarin by beta-naphthoflavone-inducible cytochrome_P-450 .
16035367	0	warfarin	49,57	cytochrome_P450_3A4	17,36	warfarin	cytochrome P450 3A4	MESH:D014859	1576	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Kinetic study of cytochrome_P450_3A4 activity on warfarin by capillary electrophoresis with fluorescence detection .
9666536	0	warfarin	20,28	factor_V_Leiden	79,94	warfarin	factor V Leiden	MESH:D014859	2153	Chemical	Gene	START_ENTITY|nmod|patients patients|nmod|mutation mutation|compound|END_ENTITY	Long-term , low-dose warfarin among venous_thrombosis patients with and without factor_V_Leiden mutation : rationale and design for the Prevention of Recurrent Venous_Thromboembolism -LRB- PREVENT -RRB- trial .
24552831	0	warfarin	64,72	factor_Xa	177,186	warfarin	factor Xa	MESH:D014859	2159	Chemical	Gene	Outcomes|nmod|START_ENTITY Outcomes|nmod|patients patients|dep|results results|nmod|rivaroxaban rivaroxaban|acl:relcl|inhibition inhibition|amod|END_ENTITY	Outcomes of temporary interruption of rivaroxaban compared with warfarin in patients with nonvalvular atrial_fibrillation : results from the rivaroxaban once daily , oral , direct factor_Xa inhibition compared with vitamin_K antagonism for prevention of stroke and embolism trial in atrial_fibrillation -LRB- ROCKET AF -RRB- .
24743444	0	warfarin	84,92	factor_Xa	150,159	warfarin	factor Xa	MESH:D014859	2159	Chemical	Gene	START_ENTITY|dep|inhibition inhibition|compound|END_ENTITY	Intracranial_hemorrhage among patients with atrial_fibrillation anticoagulated with warfarin or rivaroxaban : the rivaroxaban once daily , oral , direct factor_Xa inhibition compared with vitamin_K antagonism for prevention of stroke and embolism trial in atrial_fibrillation .
1412183	0	warfarin	36,44	fibrinogen	48,58	warfarin	fibrinogen	MESH:D014859	2244	Chemical	Gene	treatment|nmod|START_ENTITY Effects|nmod|treatment Effects|nmod|END_ENTITY	Effects of long-term treatment with warfarin on fibrinogen , FPA , TAT , and D-dimer in patients with coronary_artery_disease .
7653443	0	warfarin	11,19	fibrinogen	38,48	warfarin	fibrinogen	MESH:D014859	2244	Chemical	Gene	therapy|compound|START_ENTITY therapy|nmod|END_ENTITY	Effects of warfarin therapy on plasma fibrinogen , von_Willebrand factor , and fibrin D-dimer in left ventricular_dysfunction secondary to coronary_artery_disease with and without aneurysms .
4024210	0	warfarin	80,88	prothrombin	56,67	warfarin	prothrombin	MESH:D014859	2147	Chemical	Gene	therapy|compound|START_ENTITY response|nmod|therapy response|compound|END_ENTITY	Bayesian pharmacokinetic/pharmacodynamic forecasting of prothrombin response to warfarin therapy : preliminary evaluation .
16203879	0	warfarin	58,66	thrombin	12,20	warfarin	thrombin	MESH:D014859	2147	Chemical	Gene	inhibitor|advcl|START_ENTITY inhibitor|nsubj|END_ENTITY	Oral direct thrombin inhibitor ximelagatran compared with warfarin for the prevention of venous_thromboembolism after total knee arthroplasty .
25117439	0	withaferin_A	25,37	Axl	0,3	withaferin A	Axl	MESH:C009684	558	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Axl is a novel target of withaferin_A in the induction of apoptosis and the suppression of invasion .
20438634	0	withaferin_A	83,95	P-glycoprotein	35,49	withaferin A	P-glycoprotein	MESH:C009684	5243	Chemical	Gene	overexpressing|nmod|START_ENTITY END_ENTITY|acl|overexpressing	Differential chemosensitization of P-glycoprotein overexpressing K562/Adr cells by withaferin_A and Siamois polyphenols .
24793335	0	withanolides	39,51	QR	32,34	withanolides	QR	MESH:D054358	12972(Tax:10090)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of quinone_reductase -LRB- QR -RRB- by withanolides isolated from Physalis angulata L. var .
12027740	0	withanolides	34,46	quinone_reductase	13,30	withanolides	quinone reductase	MESH:D054358	12972(Tax:10090)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of quinone_reductase by withanolides .
24793335	0	withanolides	39,51	quinone_reductase	13,30	withanolides	quinone reductase	MESH:D054358	12972(Tax:10090)	Chemical	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of quinone_reductase -LRB- QR -RRB- by withanolides isolated from Physalis angulata L. var .
15816529	9	wogonin	910,917	NAT	925,928	wogonin	NAT	MESH:C085514	6046	Chemical	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	The effects of wogonin on the NAT enzymes levels were also examined by Western blotting and flow cytometry and the changes of NAT gene expression were examined by polymerase chain reaction -LRB- PCR -RRB- and cDNA microarray .
17317108	1	wogonin	126,133	TARC	158,162	wogonin	TARC	MESH:C085514	6361	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|compound|END_ENTITY	Suppressive effect of wogonin on mite antigen-induced TARC expression .
11322923	0	wogonin	10,17	cyclooxygenase-2	81,97	wogonin	cyclooxygenase-2	MESH:C085514	19225(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|suppression suppression|nmod|END_ENTITY	Effect of wogonin , a plant flavone from Scutellaria radix , on the suppression of cyclooxygenase-2 and the induction of inducible nitric_oxide synthase in lipopolysaccharide-treated RAW 264.7 cells .
15589400	0	wogonin	66,73	cyclooxygenase-2	15,31	wogonin	cyclooxygenase-2	MESH:C085514	19225(Tax:10090)	Chemical	Gene	fibroblasts|nmod|START_ENTITY fibroblasts|nsubj|Suppression Suppression|nmod|expression expression|amod|END_ENTITY	Suppression of cyclooxygenase-2 expression of skin fibroblasts by wogonin , a plant flavone from Scutellaria radix .
15764842	7	wortmannin	1045,1055	Akt	1027,1030	wortmannin	Akt	MESH:C009687	207	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Inhibition of Akt activity with wortmannin or CREB-DNA binding with CRE-decoy injection resulted in failure of generation of ischemic tolerance .
10464177	0	wortmannin	37,47	CTLA-4	16,22	wortmannin	CTLA-4	MESH:C009687	1493	Chemical	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Augmentation of CTLA-4 expression by wortmannin : involvement of lysosomal sorting properties of CTLA-4 .
10464177	0	wortmannin	37,47	CTLA-4	96,102	wortmannin	CTLA-4	MESH:C009687	1493	Chemical	Gene	expression|nmod|START_ENTITY Augmentation|nmod|expression Augmentation|dep|involvement involvement|nmod|properties properties|nmod|END_ENTITY	Augmentation of CTLA-4 expression by wortmannin : involvement of lysosomal sorting properties of CTLA-4 .
10330161	4	wortmannin	1038,1048	ERK	962,965	wortmannin	ERK	MESH:C009687	24338(Tax:10116)	Chemical	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|activation activation|compound|END_ENTITY	In contrast , EGF-induced ERK activation was inhibited by the phosphatidylinositol-3-kinase inhibitor wortmannin , which had no effect upon FGF-induced ERK activation .
18983912	5	wortmannin	581,591	GSK3beta	653,661	wortmannin	GSK3beta	MESH:C009687	84027(Tax:10116)	Chemical	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Lithium and valproate promote but wortmannin and LY294002_attenuate PACAP-induced phosphorylation of both GSK3beta and ERK1/2 , whereas MEK inhibitor PD98059 inhibits nerve growth factor - but not PACAP-induced phosphorylation of GSK3beta , suggesting that GSK3beta operates downstream of Rapt_1 but upstream of ERK1/2 in PACAP signalling .
19771269	7	wortmannin	925,935	NaBT	963,967	wortmannin	PARP	MESH:C009687	142	Chemical	Gene	START_ENTITY|acl|combined combined|nmod|END_ENTITY	Either wortmannin or LY294002 , combined with NaBT , enhanced the activation of caspase_3 and caspase_9 , and this enhanced the subsequent cleavage of poly _ -LRB- ADP-ribose -RRB- polymerase -LRB- PARP -RRB- .
17975737	0	wortmannin	11,21	PDK1	44,48	wortmannin	PDK1	MESH:C009687	228026(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of wortmannin on phosphorylation of PDK1 , GSK3-beta , PTEN and expression of Skp2 mRNA after ischemia/reperfusion injury in the mouse kidney .
16489044	7	wortmannin	1085,1095	PI3K	1069,1073	wortmannin	ATF3	MESH:C009687	467	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	On the other hand , ATF3 expression was not affected by another PI3K inhibitor , wortmannin , as well as phosphatase and tensin homologue or dominant-negative Akt overexpression .
16227394	0	wortmannin	98,108	PKCzeta	11,18	wortmannin	PKCzeta	MESH:C009687	5590	Chemical	Gene	activity|nmod|START_ENTITY role|nmod|activity role|nmod|END_ENTITY	A role for PKCzeta in potentiation of the topoisomerase II activity and etoposide cytotoxicity by wortmannin .
19469020	0	wortmannin	37,47	Phosphoinositide_3-kinase	0,25	wortmannin	Phosphoinositide 3-kinase	MESH:C009687	18708(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Phosphoinositide_3-kinase inhibitor -LRB- wortmannin -RRB- inhibits pancreatic_cancer cell motility and migration induced by hyaluronan in vitro and peritoneal metastasis in vivo .
17975737	0	wortmannin	11,21	Skp2	84,88	wortmannin	Skp2	MESH:C009687	27401(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|mRNA mRNA|amod|END_ENTITY	Effects of wortmannin on phosphorylation of PDK1 , GSK3-beta , PTEN and expression of Skp2 mRNA after ischemia/reperfusion injury in the mouse kidney .
1627126	0	wortmannin	93,103	myosin_light_chain_kinase	56,81	wortmannin	myosin light chain kinase	MESH:C009687	338037(Tax:9913)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Inhibition of Ca -LRB- 2 + -RRB- - dependent catecholamine release by myosin_light_chain_kinase inhibitor , wortmannin , in adrenal chromaffin cells .
8120005	0	wortmannin	139,149	myosin_light_chain_kinase	102,127	wortmannin	myosin light chain kinase	MESH:C009687	4638	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Inhibition of agonist-stimulated inositol_1 ,4,5 - trisphosphate production and calcium signaling by the myosin_light_chain_kinase inhibitor , wortmannin .
8135826	0	wortmannin	46,56	myosin_light_chain_kinase	10,35	wortmannin	myosin light chain kinase	MESH:C009687	100009143(Tax:9986)	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|inhibitor inhibitor|amod|END_ENTITY	Effect of myosin_light_chain_kinase inhibitor wortmannin on the wound repair of cultured gastric_mucosal cells .
8857588	0	wortmannin	50,60	myosin_light_chain_kinase	13,38	wortmannin	myosin light chain kinase	MESH:C009687	288057(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Effects of a myosin_light_chain_kinase inhibitor , wortmannin , on cytoplasmic Ca2 + levels , myosin light chain phosphorylation and force in vascular smooth muscle .
11559593	0	wortmannin	62,72	phosphatidylinositol_3-kinase	126,155	wortmannin	phosphatidylinositol 3-kinase	MESH:C009687	5293	Chemical	Gene	endocytosis|nmod|START_ENTITY endocytosis|nmod|activation activation|nmod|Rab5 Rab5|nmod|END_ENTITY	Regulation of epidermal_growth_factor_receptor endocytosis by wortmannin through activation of Rab5 rather than inhibition of phosphatidylinositol_3-kinase .
11090628	0	wortmannin	67,77	phosphoinositide_3-kinase	27,52	wortmannin	phosphoinositide 3-kinase	MESH:C009687	5294	Chemical	Gene	determinants|nmod|START_ENTITY determinants|nmod|inhibition inhibition|amod|END_ENTITY	Structural determinants of phosphoinositide_3-kinase inhibition by wortmannin , LY294002 , quercetin , myricetin , and staurosporine .
16474002	0	wortmannin	20,30	phosphoinositide_3-kinase	205,230	wortmannin	phosphoinositide 3-kinase	MESH:C009687	18708(Tax:10090)	Chemical	Gene	effects|nmod|START_ENTITY effects|dep|B B|nmod|END_ENTITY	Opposite effects of wortmannin and 2 - -LRB- 4-morpholinyl -RRB- -8 - phenyl-1 -LRB- 4H -RRB- - benzopyran-4-one_hydrochloride on toll-like receptor-mediated nitric_oxide production : negative regulation of nuclear factor - -LCB- kappa -RCB- B by phosphoinositide_3-kinase .
22056625	0	wortmannin	68,78	phosphoinositide_3-kinase	32,57	wortmannin	phosphoinositide 3-kinase	MESH:C009687	298947(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|inhibitor inhibitor|amod|END_ENTITY	The reno-protective effect of a phosphoinositide_3-kinase inhibitor wortmannin on streptozotocin-induced proteinuric_renal_disease rats .
17456377	0	wortmannin	60,70	tumor_necrosis_factor-alpha	92,119	wortmannin	tumor necrosis factor-alpha	MESH:C009687	7124	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Expression of phosphatidylinositol_3-kinase and effects of wortmannin on the expression of tumor_necrosis_factor-alpha in ulcerative_colitis -RSB- .
1711626	0	xamoterol	54,63	beta-1-adrenoceptor	26,45	xamoterol	beta 1-adrenoceptor	MESH:D017307	153	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|agonist agonist|amod|END_ENTITY	The effect of the partial beta-1-adrenoceptor agonist xamoterol on hemodynamics and myocardial energetics in patients with idiopathic_dilated_cardiomyopathy .
2861834	0	xamoterol	10,19	beta1_adrenoceptor	40,58	xamoterol	beta1 adrenoceptor	MESH:D017307	153	Chemical	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Effect of xamoterol -LRB- ICI_118587 -RRB- , a new beta1_adrenoceptor partial agonist , on resting haemodynamic variables and exercise tolerance in patients with left_ventricular_dysfunction .
22018972	0	xanomeline	29,39	M1/M4	4,9	xanomeline	M1/M4	MESH:C075257	25111(Tax:10116)	Chemical	Gene	preferring|dobj|START_ENTITY END_ENTITY|acl|preferring	The M1/M4 preferring agonist xanomeline is analgesic in rodent models of chronic inflammatory and neuropathic_pain via central site of action .
12593756	0	xanthates	103,112	cytochrome_P450_2B1	147,166	xanthates	cytochrome P450 2B1	null	24300(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|inhibitors inhibitors|nmod|END_ENTITY	Quantitative structure-activity relationship -LRB- QSAR -RRB- and three-dimensional QSAR analysis of a series of xanthates as inhibitors and inactivators of cytochrome_P450_2B1 .
12614873	0	xanthene_carboxamides	36,57	CCR1	65,69	xanthene carboxamides	CCR1	null	1230	Chemical	Gene	antagonists|compound|START_ENTITY antagonists|nummod|END_ENTITY	Structure-activity relationships of xanthene_carboxamides , novel CCR1 receptor antagonists .
25205467	0	xanthenone	19,29	ACE2	0,4	xanthenone	ACE2	CHEBI:37647	302668(Tax:10116)	Chemical	Gene	activation|nmod|START_ENTITY activation|nummod|END_ENTITY	ACE2 activation by xanthenone prevents leptin-induced increases_in_blood_pressure and proteinuria during pregnancy in Sprague-Dawley_rats .
8800359	0	xanthine	24,32	IGF-I	75,80	xanthine	IGF-I	MESH:D019820	3479	Chemical	Gene	I|amod|START_ENTITY I|appos|END_ENTITY	Increased expression of xanthine oxidase and insulin-like growth factor I -LRB- IGF-I -RRB- immunoreactivity in skeletal muscle after strenuous exercise in humans .
16758302	0	xanthine	17,25	Myeloperoxidase	0,15	xanthine	Myeloperoxidase	MESH:D019820	4353	Chemical	Gene	dismutase|nsubj|START_ENTITY dismutase|advmod|END_ENTITY	Myeloperoxidase , xanthine oxidase and superoxide dismutase in the gastric mucosa of Helicobacter_pylori positive and negative pediatric patients .
16329160	0	xanthine	35,43	adenosine_deaminase	14,33	xanthine	adenosine deaminase	MESH:D019820	100	Chemical	Gene	oxidase|amod|START_ENTITY oxidase|amod|END_ENTITY	Nitric_oxide , adenosine_deaminase , xanthine oxidase and superoxide_dismutase in patients with panic_disorder : alterations by antidepressant treatment .
16112416	0	xanthine	61,69	catalase	51,59	xanthine	catalase	MESH:D019820	847	Chemical	Gene	oxidase|amod|START_ENTITY oxidase|amod|END_ENTITY	Glutathione peroxidase , glutathione-S-transferase , catalase , xanthine oxidase , Cu-Zn_superoxide dismutase activities , total glutathione , nitric_oxide , and malondialdehyde levels in erythrocytes of patients with small cell and non-small_cell_lung_cancer .
2386536	0	xanthine	49,57	catalase	67,75	xanthine	catalase	MESH:D019820	24248(Tax:10116)	Chemical	Gene	START_ENTITY|dobj|peroxidase peroxidase|amod|END_ENTITY	Glutathione-S-transferase , superoxide dismutase , xanthine oxidase , catalase , glutathione peroxidase and lipid peroxidation in the liver of exercised rats .
8738764	0	xanthine	91,99	cytochrome_P4501A2	71,89	xanthine	cytochrome P4501A2	MESH:D019820	1544	Chemical	Gene	oxidase|amod|START_ENTITY oxidase|amod|END_ENTITY	Determination of urinary metabolites of caffeine for the assessment of cytochrome_P4501A2 , xanthine oxidase , and N-acetyltransferase activity in humans .
15324486	0	xanthine	146,154	cytochrome_P450_1A2	125,144	xanthine	cytochrome P450 1A2	MESH:D019820	1544	Chemical	Gene	oxidase|amod|START_ENTITY oxidase|amod|END_ENTITY	The in-vivo effect of bakumondo-to -LRB- TJ-29 -RRB- , a traditional Japanese medicine used for treatment of chronic_airway_disease , on cytochrome_P450_1A2 , xanthine oxidase and N-acetyltransferase_2 activity in man .
16112416	0	xanthine	61,69	glutathione-S-transferase	24,49	xanthine	glutathione-S-transferase	MESH:D019820	373156	Chemical	Gene	oxidase|amod|START_ENTITY oxidase|amod|END_ENTITY	Glutathione peroxidase , glutathione-S-transferase , catalase , xanthine oxidase , Cu-Zn_superoxide dismutase activities , total glutathione , nitric_oxide , and malondialdehyde levels in erythrocytes of patients with small cell and non-small_cell_lung_cancer .
15808411	0	xanthine	8,16	lactoperoxidase	26,41	xanthine	lactoperoxidase	MESH:D019820	280844(Tax:9913)	Chemical	Gene	Role|nmod|START_ENTITY Role|amod|END_ENTITY	Role of xanthine oxidase , lactoperoxidase , and NO in the innate immune system of mammary secretion during active involution in dairy cows : manipulation with casein hydrolyzates .
22168506	0	xanthine	29,37	paraoxonase_1	14,27	xanthine	paraoxonase 1	MESH:D019820	5444	Chemical	Gene	oxidase|amod|START_ENTITY oxidase|amod|END_ENTITY	Assessment of paraoxonase_1 , xanthine oxidase and glutathione peroxidase activities , nitric_oxide and thiol levels in women with polycystic_ovary_syndrome .
1475527	0	xanthine	38,46	xanthine_dehydrogenase	15,37	xanthine	xanthine dehydrogenase	MESH:D019820	497811(Tax:10116)	Chemical	Gene	ratio|compound|START_ENTITY ratio|amod|END_ENTITY	Changes in the xanthine_dehydrogenase / xanthine oxidase ratio in the rat kidney subjected to ischemia-reperfusion stress : preventive effect of some flavonoids .
8141312	0	xanthine	54,62	xanthine_dehydrogenase	31,53	xanthine	xanthine dehydrogenase	MESH:D019820	280960(Tax:9913)	Chemical	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of endothelial cell xanthine_dehydrogenase xanthine oxidase gene expression by oxygen tension .
8004443	0	xanthines	25,34	CA3	97,100	xanthines	CA3	MESH:D014970	100306971(Tax:10141)	Chemical	Gene	START_ENTITY|nmod|neurons neurons|nummod|END_ENTITY	Epileptogenic actions of xanthines in relation to their affinities for adenosine A1 receptors in CA3 neurons of hippocampal slices -LRB- guinea_pig -RRB- .
17352678	0	xanthines	46,55	DPP-IV	27,33	xanthines	DPP-IV	MESH:D014970	1803	Chemical	Gene	inhibitors|dep|START_ENTITY inhibitors|amod|END_ENTITY	Aromatic heterocycle-based DPP-IV inhibitors : xanthines and related structural types .
2772222	0	xanthines	17,26	PGF2_alpha_and_PGD2	59,78	xanthines	PGF2 alpha and PGD2	MESH:D014970	5730	Chemical	Gene	influence|nmod|START_ENTITY influence|nmod|END_ENTITY	The influence of xanthines on the contractile responses of PGF2_alpha_and_PGD2 in human parenchymal strips .
17590382	0	xanthohumol	22,33	BaP	78,81	xanthohumol	BaP	MESH:C104536	11331	Chemical	Gene	_|amod|START_ENTITY _|appos|END_ENTITY	Protective effects of xanthohumol against the genotoxicity of benzo -LRB- a -RRB- pyrene _ -LRB- BaP -RRB- , _ 2-amino-3-methylimidazo -LSB- 4,5-f -RSB- quinoline -LRB- IQ -RRB- and tert-butyl_hydroperoxide -LRB- t-BOOH -RRB- in HepG2 human hepatoma cells .
22946339	0	xanthohumol	17,28	IL-2	38,42	xanthohumol	IL-2	MESH:C104536	16183(Tax:10090)	Chemical	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Anticancer agent xanthohumol inhibits IL-2 induced signaling pathways involved in T cell proliferation .
18952893	0	xanthohumol	84,95	IkappaBalpha	41,53	xanthohumol	IkappaBalpha	MESH:C104536	4792	Chemical	Gene	kinase|nmod|START_ENTITY kinase|compound|END_ENTITY	Modification of the cysteine residues in IkappaBalpha kinase and NF-kappaB -LRB- p65 -RRB- by xanthohumol leads to suppression of NF-kappaB-regulated gene products and potentiation of apoptosis in leukemia cells .
16092069	0	xanthohumol	32,43	UDP-glucuronosyltransferases	53,81	xanthohumol	UDP-glucuronosyltransferases	MESH:C104536	135152	Chemical	Gene	metabolism|nmod|START_ENTITY metabolism|nmod|END_ENTITY	In vitro phase II metabolism of xanthohumol by human UDP-glucuronosyltransferases and sulfotransferases .
26209362	0	xanthone	10,18	catalase	29,37	xanthone	catalase	MESH:C009689	847	Chemical	Gene	increases|nsubj|START_ENTITY increases|dobj|activity activity|amod|END_ENTITY	A natural xanthone increases catalase activity but decreases NF-kappa_B and lipid peroxidation in U-937 and HepG2 cell lines .
16236271	0	xanthone	15,23	transthyretin	39,52	xanthone	transthyretin	MESH:C009689	7276	Chemical	Gene	derivatives|amod|START_ENTITY derivatives|nmod|END_ENTITY	The binding of xanthone derivatives to transthyretin .
15875766	0	xenoestrogen	35,47	CD-1	99,103	xenoestrogen	CD-1	null	111334(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|mice mice|compound|END_ENTITY	Effects of prepubertal exposure to xenoestrogen on development of estrogen target organs in female CD-1 mice .
19145065	0	xenoestrogen	35,47	growth_hormone	61,75	xenoestrogen	growth hormone	null	81668(Tax:10116)	Chemical	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	Estrogen receptors are involved in xenoestrogen induction of growth_hormone in the rat pituitary gland .
11836149	0	xenoestrogens	96,109	UDP-glucuronosyltransferase	50,77	xenoestrogens	UDP-glucuronosyltransferase	null	24862(Tax:10116)	Chemical	Gene	activities|nmod|START_ENTITY activities|amod|END_ENTITY	Developmental increases in rat hepatic microsomal UDP-glucuronosyltransferase activities toward xenoestrogens and decreases during pregnancy .
12030773	0	xenoestrogens	38,51	prolactin	14,23	xenoestrogens	prolactin	null	24683(Tax:10116)	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|expression expression|compound|END_ENTITY	Modulation of prolactin expression by xenoestrogens .
21722086	0	xenoestrogens	11,24	vitellogenin	46,58	xenoestrogens	vitellogenin	null	101882735	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effects of xenoestrogens on the expression of vitellogenin -LRB- vtg -RRB- and cytochrome_P450_aromatase -LRB- cyp19a and b -RRB- genes in zebrafish -LRB- Danio_rerio -RRB- larvae .
14624047	0	ximelagatran	46,58	p-selectin	62,72	ximelagatran	p-selectin	MESH:C426686	6403	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effects of the oral direct thrombin inhibitor ximelagatran on p-selectin expression and thrombin generation in atrial_fibrillation .
11575978	0	ximelagatran	49,61	thrombin	30,38	ximelagatran	thrombin	MESH:C426686	2147	Chemical	Gene	inhibitor|acl|START_ENTITY inhibitor|compound|END_ENTITY	Comparison of the oral direct thrombin inhibitor ximelagatran with enoxaparin as prophylaxis against venous_thromboembolism after total knee replacement : a phase 2 dose-finding study .
11858491	0	ximelagatran	72,84	thrombin	14,22	ximelagatran	thrombin	MESH:C426686	2147	Chemical	Gene	generation|nmod|START_ENTITY generation|compound|END_ENTITY	Inhibition of thrombin generation by the oral direct thrombin inhibitor ximelagatran in shed blood from healthy male subjects .
12489490	0	ximelagatran	70,82	thrombin	50,58	ximelagatran	thrombin	MESH:C426686	2147	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Treatment of venous_thromboembolism with the oral thrombin inhibitor , ximelagatran .
12574809	0	ximelagatran	54,66	thrombin	7,15	ximelagatran	thrombin	MESH:C426686	2147	Chemical	Gene	followed|nmod|START_ENTITY followed|nsubj|melagatran melagatran|compound|END_ENTITY	Direct thrombin inhibitor melagatran followed by oral ximelagatran in comparison with enoxaparin for prevention of venous_thromboembolism after total hip or knee replacement .
12584156	0	ximelagatran	55,67	thrombin	84,92	ximelagatran	thrombin	MESH:C426686	29251(Tax:10116)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Absorption , distribution , metabolism , and excretion of ximelagatran , an oral direct thrombin inhibitor , in rats , dogs , and humans .
12598065	0	ximelagatran	11,23	thrombin	88,96	ximelagatran	thrombin	MESH:C426686	2147	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|generation generation|compound|END_ENTITY	Effects of ximelagatran , an oral direct thrombin inhibitor , r-hirudin and enoxaparin on thrombin generation and platelet activation in healthy male subjects .
12648028	0	ximelagatran	65,77	thrombin	94,102	ximelagatran	thrombin	MESH:C426686	2147	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Influence of age on the pharmacokinetics and pharmacodynamics of ximelagatran , an oral direct thrombin inhibitor .
12739985	0	ximelagatran	122,134	thrombin	156,164	ximelagatran	thrombin	MESH:C426686	2147	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	No influence of ethnic origin on the pharmacokinetics and pharmacodynamics of melagatran following oral administration of ximelagatran , a novel oral direct thrombin inhibitor , to healthy male volunteers .
12743672	0	ximelagatran	41,53	thrombin	75,83	ximelagatran	thrombin	MESH:C426686	2147	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Pharmacokinetics and pharmacodynamics of ximelagatran , a novel oral direct thrombin inhibitor , in young healthy male subjects .
12846596	0	ximelagatran	100,112	thrombin	129,137	ximelagatran	thrombin	MESH:C426686	2147	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	No influence of mild-to-moderate hepatic_impairment on the pharmacokinetics and pharmacodynamics of ximelagatran , an oral direct thrombin inhibitor .
12955372	0	ximelagatran	66,78	thrombin	47,55	ximelagatran	thrombin	MESH:C426686	2147	Chemical	Gene	START_ENTITY|nsubj|pharmacokinetics pharmacokinetics|nmod|inhibitor inhibitor|compound|END_ENTITY	Consistent pharmacokinetics of the oral direct thrombin inhibitor ximelagatran in patients with nonvalvular_atrial_fibrillation and in healthy subjects .
14521593	0	ximelagatran	14,26	thrombin	43,51	ximelagatran	thrombin	MESH:C426686	2147	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Comparison of ximelagatran , an oral direct thrombin inhibitor , with enoxaparin for the prevention of venous_thromboembolism following total hip replacement .
14624047	0	ximelagatran	46,58	thrombin	27,35	ximelagatran	thrombin	MESH:C426686	2147	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|inhibitor inhibitor|compound|END_ENTITY	Effects of the oral direct thrombin inhibitor ximelagatran on p-selectin expression and thrombin generation in atrial_fibrillation .
14643116	0	ximelagatran	58,70	thrombin	39,47	ximelagatran	thrombin	MESH:C426686	2147	Chemical	Gene	START_ENTITY|nsubj|prevention prevention|nmod|inhibitor inhibitor|compound|END_ENTITY	Stroke prevention with the oral direct thrombin inhibitor ximelagatran compared with warfarin in patients with non-valvular atrial_fibrillation -LRB- SPORTIF III -RRB- : randomised controlled trial .
14675083	0	ximelagatran	58,70	thrombin	11,19	ximelagatran	thrombin	MESH:C426686	2147	Chemical	Gene	followed|nmod|START_ENTITY followed|nsubj|melagatran melagatran|compound|END_ENTITY	The direct thrombin inhibitor melagatran followed by oral ximelagatran compared with enoxaparin for the prevention of venous_thromboembolism after total hip or knee replacement : the EXPRESS study .
15051746	0	ximelagatran	45,57	thrombin	74,82	ximelagatran	thrombin	MESH:C426686	2147	Chemical	Gene	pharmacokinetics|nmod|START_ENTITY pharmacokinetics|appos|inhibitor inhibitor|compound|END_ENTITY	The pharmacokinetics and pharmacodynamics of ximelagatran , an oral direct thrombin inhibitor , are unaffected by a single dose of alcohol .
15151465	0	ximelagatran	47,59	thrombin	76,84	ximelagatran	thrombin	MESH:C426686	2147	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Antithrombotic therapy in atrial_fibrillation : ximelagatran , an oral direct thrombin inhibitor .
16084146	0	ximelagatran	47,59	thrombin	28,36	ximelagatran	thrombin	MESH:C426686	2147	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|review review|nmod|END_ENTITY	A review of the oral direct thrombin inhibitor ximelagatran : not yet the end of the warfarin era ... Ximelagatran is a direct thrombin inhibitor that offers numerous potential advantages compared with traditional anticoagulants .
16194202	0	ximelagatran	25,37	thrombin	54,62	ximelagatran	thrombin	MESH:C426686	2147	Chemical	Gene	treatment|nmod|START_ENTITY treatment|appos|inhibitor inhibitor|compound|END_ENTITY	Long-term treatment with ximelagatran , an oral direct thrombin inhibitor , persistently reduces the coagulation activity after a myocardial_infarction .
16203879	0	ximelagatran	31,43	thrombin	12,20	ximelagatran	thrombin	MESH:C426686	2147	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|END_ENTITY	Oral direct thrombin inhibitor ximelagatran compared with warfarin for the prevention of venous_thromboembolism after total knee arthroplasty .
16430312	0	ximelagatran	76,88	thrombin	57,65	ximelagatran	thrombin	MESH:C426686	2147	Chemical	Gene	START_ENTITY|nsubj|Pharmacokinetics Pharmacokinetics|nmod|inhibitor inhibitor|compound|END_ENTITY	Pharmacokinetics and pharmacodynamics of the oral direct thrombin inhibitor ximelagatran in young healthy Japanese men .
18215612	0	ximelagatran	10,22	thrombin	169,177	ximelagatran	thrombin	MESH:C426686	2147	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|patients patients|nmod|trial trial|amod|atrial_fibrillation atrial_fibrillation|nmod|myocardial_infarction myocardial_infarction|nmod|efficacy efficacy|nmod|ximelagatran ximelagatran|compound|END_ENTITY	Effect of ximelagatran on ischemic events and death in patients with atrial_fibrillation after acute myocardial_infarction in the efficacy and safety of the oral direct thrombin inhibitor ximelagatran in patients with recent myocardial_damage -LRB- ESTEEM -RRB- trial .
18716776	0	ximelagatran	59,71	thrombin	106,114	ximelagatran	thrombin	MESH:C426686	29251(Tax:10116)	Chemical	Gene	response|nmod|START_ENTITY response|dep|implications implications|nmod|inhibitors inhibitors|compound|END_ENTITY	Vitamin_K_deficiency amplifies anticoagulation response to ximelagatran : possible implications for direct thrombin inhibitors and their clinical safety .
19028773	0	ximelagatran	13,25	thrombin	80,88	ximelagatran	thrombin	MESH:C426686	2147	Chemical	Gene	Lessons|nmod|START_ENTITY Lessons|dep|issues issues|acl|evaluating evaluating|dobj|inhibitors inhibitors|compound|END_ENTITY	Lessons from ximelagatran : issues for future studies evaluating new oral direct thrombin inhibitors for venous_thromboembolism prophylaxis in orthopedic surgery .
19741508	0	ximelagatran	101,113	thrombin	82,90	ximelagatran	thrombin	MESH:C426686	2147	Chemical	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|Management Management|nmod|bleedings bleedings|nmod|treatment treatment|nmod|END_ENTITY	Management of major bleedings during anticoagulant treatment with the oral direct thrombin inhibitor ximelagatran or warfarin .
20681149	0	xylazine	16,24	oxytocin	47,55	xylazine	oxytocin	MESH:D014991	5020	Chemical	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of xylazine and acepromazine with oxytocin and the effects of these interactions on intrauterine pressure in normal mares and mares with delayed uterine clearance .
2774837	0	xylazine	14,22	prolactin	38,47	xylazine	prolactin	MESH:D014991	24683(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|concentrations concentrations|compound|END_ENTITY	The effect of xylazine on basal serum prolactin concentrations in male rats .
8846999	0	xylene	22,28	musk	17,21	xylene	musk	MESH:D014992	18198(Tax:10090)	Chemical	Gene	START_ENTITY|nsubj|evaluation evaluation|nmod|END_ENTITY	An evaluation of musk xylene in a battery of genotoxicity tests .
7049804	0	xylitol	15,22	insulin_and_gastric_inhibitory_polypeptide	43,85	xylitol	insulin and gastric inhibitory polypeptide	MESH:D014993	2695	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|secretion secretion|nmod|END_ENTITY	The effects of xylitol on the secretion of insulin_and_gastric_inhibitory_polypeptide in man and rats .
738856	0	xylitol	36,43	oxidoreductase	51,65	xylitol	oxidoreductase	MESH:D014993	7296	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	Effect of peroral administration of xylitol on the oxidoreductase activity of human blood cells and certain chemical properties of saliva and serum .
23135544	0	xylose	26,32	LARGE2	0,6	xylose	LARGE2	MESH:D014994	120071	Chemical	Gene	generates|dobj|START_ENTITY generates|nsubj|END_ENTITY	LARGE2 generates the same xylose - and glucuronic_acid-containing glycan structures as LARGE .
22059425	0	y-Glutamyl	0,10	adiponectin	49,60	y-Glutamyl	adiponectin	null	9370	Chemical	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	y-Glutamyl transferase and high-molecular-weight adiponectin levels are synergistically associated with metabolic_syndrome and insulin resistance in community-dwelling persons .
22293775	0	y-Tocotrienol	0,13	MCP-1	83,88	y-Tocotrienol	MCP-1	null	6347	Chemical	Gene	changes|amod|START_ENTITY changes|nmod|END_ENTITY	y-Tocotrienol attenuates TNF-a-induced changes in secretion and gene expression of MCP-1 , IL-6 and adiponectin in 3T3-L1 adipocytes .
21198544	0	y-Tocotrienol	0,13	STAT3	65,70	y-Tocotrienol	STAT3	null	6774	Chemical	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	y-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular_carcinoma : potential role as an antiproliferative , pro-apoptotic and chemosensitizing agent .
21335085	0	y-Tocotrienol	0,13	TGFb2	65,70	y-Tocotrienol	TGFb2	null	7042	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|pathway pathway|nmod|END_ENTITY	y-Tocotrienol induces growth arrest through a novel pathway with TGFb2 in prostate_cancer .
27055589	0	y-Tocotrienol	0,13	aryl_hydrocarbon_receptor	26,51	y-Tocotrienol	aryl hydrocarbon receptor	null	196	Chemical	Gene	upregulates|amod|START_ENTITY END_ENTITY|nsubj|upregulates	y-Tocotrienol upregulates aryl_hydrocarbon_receptor expression and enhances the anticancer effect of baicalein .
22896705	0	y-aminobutyric_acid	16,35	GAT2	51,55	y-aminobutyric acid	GAT2	null	14412(Tax:10090)	Chemical	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Deletion of the y-aminobutyric_acid transporter 2 -LRB- GAT2 and SLC6A13 -RRB- gene in mice leads to changes in liver and brain taurine contents .
21276435	0	y-hydroxybutyrate	59,76	AKR1A1	31,37	y-hydroxybutyrate	AKR1A1	null	10327	Chemical	Gene	metabolism|nmod|START_ENTITY role|nmod|metabolism role|nmod|END_ENTITY	The role of aldehyde_reductase AKR1A1 in the metabolism of y-hydroxybutyrate in 1321N1 human astrocytoma cells .
25619388	0	y-oryzanol	0,10	caveolin-1	19,29	y-oryzanol	caveolin-1	null	857	Chemical	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|amod|END_ENTITY	y-oryzanol reduces caveolin-1 and PCGEM1 expression , markers of aggressiveness in prostate_cancer cell lines .
26140534	0	y-oryzanol	56,66	dopamine_D2_receptor	96,116	y-oryzanol	dopamine D2 receptor	null	13489(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|suppression suppression|nmod|END_ENTITY	A novel insulinotropic mechanism of whole grain-derived y-oryzanol via the suppression of local dopamine_D2_receptor signalling in mouse islet .
12086399	0	yakuchinone_A	11,24	COX-2	86,91	yakuchinone A	COX-2	MESH:C042566	19225(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of yakuchinone_A and yakuchinone_B on the phorbol_ester-induced expression of COX-2 and iNOS and activation of NF-kappaB in mouse skin .
23194622	0	yangambin	23,32	PAF	64,67	yangambin	PAF	MESH:C082827	300795(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Antagonistic effect of yangambin on platelet-activating factor -LRB- PAF -RRB- - induced cardiovascular_collapse .
23194622	6	yangambin	984,993	PAF	1053,1056	yangambin	PAF	MESH:C082827	300795(Tax:10116)	Chemical	Gene	antagonist|nsubj|START_ENTITY antagonist|nmod|effects effects|nmod|END_ENTITY	It is concluded that yangambin is a selective antagonist of the cardiovascular effects of PAF and therefore constitutes a potential therapeutic agent in different shock states where abnormal PAF release is supposed to play an important role .
3409962	0	yohimbine	88,97	Angiotensin_II	0,14	yohimbine	Angiotensin II	MESH:D015016	24179(Tax:10116)	Chemical	Gene	treated|nmod|START_ENTITY rats|acl|treated maintenance|nmod|rats contributes|nmod|maintenance contributes|nsubj|END_ENTITY	Angiotensin_II contributes to blood pressure maintenance in conscious rats treated with yohimbine .
16968802	0	yohimbine	36,45	Salivary_alpha-amylase	0,22	yohimbine	Salivary alpha-amylase	MESH:D015016	276	Chemical	Gene	levels|nmod|START_ENTITY levels|amod|END_ENTITY	Salivary_alpha-amylase levels after yohimbine challenge in healthy men .
2626080	2	yohimbine	131,140	angiotensin_II	111,125	yohimbine	angiotensin II	MESH:D015016	24179(Tax:10116)	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of angiotensin_II with yohimbine .
8177507	0	yohimbine	10,19	nerve_growth_factor	23,42	yohimbine	nerve growth factor	MESH:D015016	310738(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|mRNA mRNA|compound|END_ENTITY	Effect of yohimbine on nerve_growth_factor mRNA and protein levels in rat hippocampus .
9608581	0	yohimbine	86,95	neuropeptide_Y	7,21	yohimbine	neuropeptide Y	MESH:D015016	4852	Chemical	Gene	increases|nmod|START_ENTITY increases|nsubj|END_ENTITY	Plasma neuropeptide_Y -LRB- NPY -RRB- increases in humans in response to the alpha 2 antagonist yohimbine .
6294278	0	yohimbine	10,19	prolactin	27,36	yohimbine	prolactin	MESH:D015016	24683(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of yohimbine on rat prolactin secretion .
3963600	0	yohimbine_hydrochloride	10,33	prolactin	43,52	yohimbine hydrochloride	prolactin	MESH:D015016	24683(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|concentration concentration|compound|END_ENTITY	Effect of yohimbine_hydrochloride on serum prolactin concentration in the rat : possible antagonist for fescue_toxicosis .
20930371	0	youngiasides	76,88	quinone_reductase	31,48	youngiasides	quinone reductase	null	12972(Tax:10090)	Chemical	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	Bi-functional induction of the quinone_reductase and cytochrome_P450_1A1 by youngiasides via Nrf2-ARE and AhR-XRE pathways .
19558356	0	yuanhuacine	84,95	DNA_topoisomerase_I	105,124	yuanhuacine	DNA topoisomerase I	MESH:C029912	21969(Tax:10090)	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Evaluation of poly -LRB- D,L-lactide-co-glycolide -RRB- microspheres for the lung-targeting of yuanhuacine , a novel DNA_topoisomerase_I inhibitor .
17139194	0	z-335	20,25	thromboxane_A2_receptor	33,56	z-335	thromboxane A2 receptor	MESH:C115527	100008908(Tax:9986)	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Distinct effects of z-335 , a new thromboxane_A2_receptor antagonist , on rabbit platelets and aortic smooth muscle .
25915766	0	z-FA-FMK	81,89	Cathepsin_B	58,69	z-FA-FMK	Cathepsin B	MESH:C057383	1508	Chemical	Gene	Inhibitor|appos|START_ENTITY Inhibitor|compound|END_ENTITY	Suppression of Human T Cell Proliferation Mediated by the Cathepsin_B Inhibitor , z-FA-FMK Is Due to Oxidative Stress .
25915766	0	z-FA-FMK	81,89	Cathepsin_B	58,69	z-FA-FMK	Cathepsin B	MESH:C057383	1508	Chemical	Gene	Inhibitor|appos|START_ENTITY Inhibitor|compound|END_ENTITY	Suppression of Human T Cell Proliferation Mediated by the Cathepsin_B Inhibitor , z-FA-FMK Is Due to Oxidative Stress .
16951345	0	z-FA-FMK	27,35	cathepsin_B	4,15	z-FA-FMK	cathepsin B	MESH:C057383	13030(Tax:10090)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	The cathepsin_B inhibitor , z-FA-FMK , inhibits human T cell proliferation in vitro and modulates host response to pneumococcal_infection in vivo .
15796358	0	z-LEHD-fmk	85,95	caspase-9	65,74	z-LEHD-fmk	caspase-9	MESH:C403754	58918(Tax:10116)	Chemical	Gene	START_ENTITY|nsubj|recovery recovery|nmod|application application|nmod|inhibitor inhibitor|amod|END_ENTITY	Neuroprotection and functional recovery after application of the caspase-9 inhibitor z-LEHD-fmk in a rat model of traumatic spinal_cord_injury .
16724555	0	zalcitabine	15,26	organic_anion_transporter_1	38,65	zalcitabine	organic anion transporter 1	MESH:D016047	9356	Chemical	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of zalcitabine with human organic_anion_transporter_1 .
9194406	0	zaldaride_maleate	119,136	calmodulin	97,107	zaldaride maleate	calmodulin	MESH:C052087	808	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Toxicity of cadmium in human trophoblast cells -LRB- JAr_choriocarcinoma -RRB- : role of calmodulin and the calmodulin inhibitor , zaldaride_maleate .
12236850	0	zaltoprofen	54,65	CYP2C9	15,21	zaltoprofen	CYP2C9	MESH:C043940	1559	Chemical	Gene	metabolism|nmod|START_ENTITY Involvement|nmod|metabolism Involvement|nmod|END_ENTITY	Involvement of CYP2C9 and UGT2B7 in the metabolism of zaltoprofen , a nonsteroidal anti-inflammatory drug , and its lack of clinically significant CYP inhibition potential .
9395349	0	zanamavir	39,48	neuraminidase	15,28	zanamavir	neuraminidase	null	4758	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Effects of the neuraminidase inhibitor zanamavir on otologic manifestations of experimental human influenza .
11197587	0	zanamivir	26,35	Neuraminidase	0,13	zanamivir	Neuraminidase	MESH:D053243	4758	Chemical	Gene	inhibitors|dep|START_ENTITY inhibitors|amod|END_ENTITY	Neuraminidase inhibitors : zanamivir and oseltamivir .
12821478	0	zanamivir	93,102	Neuraminidase	0,13	zanamivir	Neuraminidase	MESH:D053243	4758	Chemical	Gene	isolates|nmod|START_ENTITY isolates|nsubj|analysis analysis|amod|END_ENTITY	Neuraminidase sequence analysis and susceptibilities of influenza virus clinical isolates to zanamivir and oseltamivir .
14575130	0	zanamivir	66,75	neuraminidase	124,137	zanamivir	neuraminidase	MESH:D053243	4758	Chemical	Gene	susceptibility|nmod|START_ENTITY susceptibility|dep|comparison comparison|nmod|assays assays|compound|END_ENTITY	Assaying susceptibility of avian and other influenza A viruses to zanamivir : comparison of fluorescent and chemiluminescent neuraminidase assays .
16125799	0	zanamivir	36,45	neuraminidase	143,156	zanamivir	neuraminidase	MESH:D053243	4758	Chemical	Gene	viruses|nmod|START_ENTITY Sensitivity|nmod|viruses Sensitivity|dep|study study|acl|performed performed|nmod|viruses viruses|acl|circulating circulating|advcl|introduction introduction|nmod|inhibitors inhibitors|amod|END_ENTITY	Sensitivity of influenza viruses to zanamivir and oseltamivir : a study performed on viruses circulating in France prior to the introduction of neuraminidase inhibitors in clinical practice .
22970161	0	zanamivir	27,36	neuraminidase	53,66	zanamivir	neuraminidase	MESH:D053243	4758	Chemical	Gene	resistance|compound|START_ENTITY mechanism|nmod|resistance Exploring|dobj|mechanism Exploring|nmod|mutant mutant|amod|END_ENTITY	Exploring the mechanism of zanamivir resistance in a neuraminidase mutant : a molecular dynamics study .
25272593	0	zanamivir	67,76	neuraminidase	50,63	zanamivir	neuraminidase	MESH:D053243	4758	Chemical	Gene	-RSB-|compound|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- Drug susceptibility of wild-type and mutant H7N9 neuraminidase to zanamivir and oseltamivir -RSB- .
25599664	0	zanamivir	161,170	neuraminidase	104,117	zanamivir	neuraminidase	MESH:D053243	4758	Chemical	Gene	measure|nmod|START_ENTITY measure|dobj|affinity affinity|nmod|END_ENTITY	Development of a surface plasmon resonance assay to measure the binding affinity of wild-type influenza neuraminidase and its H274Y mutant to the antiviral drug zanamivir .
9302301	0	zanamivir	51,60	neuraminidase	27,40	zanamivir	neuraminidase	MESH:D053243	4758	Chemical	Gene	START_ENTITY|nsubj|Efficacy Efficacy|nmod|inhibitor inhibitor|amod|END_ENTITY	Efficacy and safety of the neuraminidase inhibitor zanamivir in the treatment of influenzavirus infections .
22381066	0	zapotin	24,31	protein_kinase_C_epsilon	54,78	zapotin	protein kinase C epsilon	MESH:C517807	5581	Chemical	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	The tetramethoxyflavone zapotin selectively activates protein_kinase_C_epsilon , leading to its down-modulation accompanied by Bcl-2 , c-Jun and c-Fos decrease .
7721822	0	zaragozic_acid_A	56,72	squalene_synthetase	24,43	zaragozic acid A	squalene synthetase	MESH:C075117	2222	Chemical	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Inhibition of mammalian squalene_synthetase activity by zaragozic_acid_A is a result of competitive inhibition followed by mechanism-based irreversible inactivation .
16547076	0	zearalenone	17,28	CYP3A	37,42	zearalenone	CYP3A	MESH:D015025	1576	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	The mycoestrogen zearalenone induces CYP3A through activation of the pregnane_X_receptor .
24275814	0	zearalenone	10,21	F-2	23,26	zearalenone	F-2	MESH:D015025	29251(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of zearalenone -LRB- F-2 -RRB- on pea stem , maize root , and rat liver mitochondria .
11205083	0	zearalenone	38,49	SKN	78,81	zearalenone	SKN	MESH:D015025	55733	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Agonistic and antagonistic effects of zearalenone , an etrogenic mycotoxin , on SKN , HHUA , and HepG2 human cancer cell lines .
21767629	0	zearalenone	10,21	p53	71,74	zearalenone	p53	MESH:D015025	22060(Tax:10090)	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Mycotoxin zearalenone induces AIF - and ROS-mediated cell death through p53 - and MAPK-dependent signaling pathways in RAW264 .7 macrophages .
16547076	0	zearalenone	17,28	pregnane_X_receptor	69,88	zearalenone	pregnane X receptor	MESH:D015025	8856	Chemical	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	The mycoestrogen zearalenone induces CYP3A through activation of the pregnane_X_receptor .
11911460	0	zeatin	21,27	acetylcholinesterase	63,83	zeatin	acetylcholinesterase	MESH:D015026	83817(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|amod|END_ENTITY	Inhibitory effect of zeatin , isolated from Fiatoua villosa , on acetylcholinesterase activity from PC12 cells .
19459041	0	zebularine	51,61	DNA_methyltransferase	19,40	zebularine	DNA methyltransferase	MESH:C009131	1786	Chemical	Gene	START_ENTITY|nsubj|Effects Effects|nmod|inhibitor inhibitor|compound|END_ENTITY	Effects of a novel DNA_methyltransferase inhibitor zebularine on human breast_cancer cells .
21455989	0	zebularine	37,47	DNA_methyltransferase	4,25	zebularine	DNA methyltransferase	MESH:C009131	1786	Chemical	Gene	induce|nsubj|START_ENTITY inhibitors|ccomp|induce inhibitors|nsubj|END_ENTITY	The DNA_methyltransferase inhibitors zebularine and decitabine induce mitochondria-mediated apoptosis and DNA damage in p53 mutant leukemic_T cells .
23850985	0	zederone	31,39	cytochrome_P450	70,85	zederone	cytochrome P450	null	4051	Chemical	Gene	START_ENTITY|nmod|system system|amod|END_ENTITY	Interactions of sesquiterpenes zederone and germacrone with the human cytochrome_P450 system .
16193523	0	zeolite_A	66,75	Ag2S	41,45	zeolite A	Ag2S	null	185	Chemical	Gene	Synthesis|nmod|START_ENTITY Synthesis|nmod|END_ENTITY	Synthesis and luminescence properties of Ag2S and PbS clusters in zeolite_A .
10793270	0	zeranol	122,129	growth_hormone	67,81	zeranol	growth hormone	MESH:D015029	2688	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of pituitary synthesis and secretion of growth_hormone in growing wethers and the influence of zeranol on these mechanisms .
24797723	0	zerumbone	41,50	STAT3	14,19	zerumbone	STAT3	MESH:C403304	20848(Tax:10090)	Chemical	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Abrogation of STAT3 signaling cascade by zerumbone inhibits proliferation and induces apoptosis in renal_cell_carcinoma xenograft mouse model .
2521253	0	zetidoline	26,36	dopamine_D2_receptor	40,60	zetidoline	dopamine D2 receptor	MESH:C027277	1813	Chemical	Gene	START_ENTITY|appos|antagonist antagonist|amod|END_ENTITY	Stereoelectronic study of zetidoline , a dopamine_D2_receptor antagonist .
12602459	0	zidovudine	33,43	P24	60,63	zidovudine	P24	MESH:D015215	10959	Chemical	Gene	exposure|acl|START_ENTITY Relationship|nmod|exposure Relationship|nmod|antigenemia antigenemia|compound|END_ENTITY	Relationship between exposure to zidovudine and decrease of P24 antigenemia in HIV-infected patients in monotherapy .
18611800	0	zidovudine	92,102	erythropoietin	18,32	zidovudine	erythropoietin	MESH:D015215	2056	Chemical	Gene	receiving|dobj|START_ENTITY Recombinant|advcl|receiving Recombinant|dobj|END_ENTITY	Recombinant human erythropoietin for treatment of anemia in persons with AIDS not receiving zidovudine .
2186273	0	zidovudine	69,79	erythropoietin	18,32	zidovudine	erythropoietin	MESH:D015215	2056	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|END_ENTITY	Recombinant human erythropoietin for patients with AIDS treated with zidovudine .
9402071	0	zidovudine	58,68	interferon-alpha2a	100,118	zidovudine	interferon-alpha2a	MESH:D015215	3440	Chemical	Gene	activity|nmod|START_ENTITY activity|nmod|END_ENTITY	Safety and antiviral activity of combination therapy with zidovudine , zalcitabine , and two doses of interferon-alpha2a in patients with HIV .
8011237	0	zidovudine	105,115	interleukin-2	44,57	zidovudine	interleukin-2	MESH:D015215	3558	Chemical	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	A phase I study of subcutaneous recombinant interleukin-2 in patients with advanced_HIV_disease while on zidovudine .
10945832	0	zidovudine	65,75	organic_anion_transporter_1	18,45	zidovudine	organic anion transporter 1	MESH:D015215	29509(Tax:10116)	Chemical	Gene	transports|dobj|START_ENTITY transports|nsubj|END_ENTITY	Rat multispecific organic_anion_transporter_1 -LRB- rOAT1 -RRB- transports zidovudine , acyclovir , and other antiviral nucleoside analogs .
1418778	0	zidovudine	29,39	p24	73,76	zidovudine	p24	MESH:D015215	10959	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|acyclovir acyclovir|nmod|antigenaemia antigenaemia|amod|END_ENTITY	The effect of treatment with zidovudine with or without acyclovir on HIV p24 antigenaemia in patients with AIDS or AIDS-related_complex .
1680791	0	zidovudine	42,52	p24	56,59	zidovudine	p24	MESH:D015215	10959	Chemical	Gene	START_ENTITY|nmod|antigenaemia antigenaemia|amod|END_ENTITY	The effects of twice and four times daily zidovudine on p24 antigenaemia in CDC stage II/III patients .
1707962	0	zidovudine	176,186	p24	88,91	zidovudine	p24	MESH:D015215	10959	Chemical	Gene	receiving|nmod|START_ENTITY patient|acl|receiving isolates|nmod|patient isolates|nmod|assays assays|acl:relcl|show show|dobj|dissociation dissociation|nmod|activity activity|appos|END_ENTITY	In vitro assays show a dissociation of reverse_transcriptase activity and core antigen -LRB- p24 -RRB- production in two HIV-1 isolates from a patient receiving long-term treatment with zidovudine -LRB- ZDV -RRB- .
2123627	0	zidovudine	118,128	p24	18,21	zidovudine	p24	MESH:D015215	10959	Chemical	Gene	treated|nmod|START_ENTITY Response|acl|treated Response|nmod|antigen antigen|amod|END_ENTITY	Response of serum p24 antigen and antibody to p24 antigen in patients with AIDS and AIDS-related_complex treated with zidovudine .
2123627	0	zidovudine	118,128	p24	46,49	zidovudine	p24	MESH:D015215	10959	Chemical	Gene	treated|nmod|START_ENTITY Response|acl|treated Response|nmod|antigen antigen|amod|END_ENTITY	Response of serum p24 antigen and antibody to p24 antigen in patients with AIDS and AIDS-related_complex treated with zidovudine .
2496173	0	zidovudine	24,34	p24	83,86	zidovudine	p24	MESH:D015215	10959	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|levels levels|amod|END_ENTITY	The antiviral effect of zidovudine and ribavirin in clinical trials and the use of p24 antigen levels as a virologic marker .
7632462	0	zidovudine	88,98	p24	42,45	zidovudine	p24	MESH:D015215	10959	Chemical	Gene	therapy|compound|START_ENTITY RNA|nmod|therapy RNA|nmod|levels levels|amod|END_ENTITY	Distinct changes in HIV_type_1 RNA versus p24 antigen levels in serum during short-term zidovudine therapy in asymptomatic individuals with and without progression to AIDS .
8133085	0	zidovudine	75,85	p24	6,9	zidovudine	p24	MESH:D015215	10959	Chemical	Gene	level|nmod|START_ENTITY level|amod|END_ENTITY	Serum p24 antigen level as an intermediate end point in clinical trials of zidovudine in people infected with human_immunodeficiency_virus_type_1 .
8233642	0	zidovudine	88,98	p24	26,29	zidovudine	p24	MESH:D015215	10959	Chemical	Gene	treatment|nmod|START_ENTITY follow-up|nmod|treatment antigenemia|nmod|follow-up antigenemia|amod|END_ENTITY	-LSB- Quantitative viremia and p24 antigenemia in short-term follow-up of the treatment with zidovudine in twenty HIV_infected patients -RSB- .
8780818	0	zidovudine	38,48	p24	76,79	zidovudine	p24	MESH:D015215	10959	Chemical	Gene	versus|amod|START_ENTITY nevirapine|nmod|versus trial|nmod|nevirapine zidovudine|nsubj|trial zidovudine|nmod|patients patients|amod|END_ENTITY	A controlled trial of nevirapine plus zidovudine versus zidovudine alone in p24 antigenaemic HIV-infected patients .
8780818	0	zidovudine	56,66	p24	76,79	zidovudine	p24	MESH:D015215	10959	Chemical	Gene	START_ENTITY|nmod|patients patients|amod|END_ENTITY	A controlled trial of nevirapine plus zidovudine versus zidovudine alone in p24 antigenaemic HIV-infected patients .
9468366	0	zidovudine	101,111	p24	62,65	zidovudine	p24	MESH:D015215	10959	Chemical	Gene	combined|nmod|START_ENTITY combined|nsubj|Safety Safety|nmod|vaccine vaccine|appos|particle particle|amod|END_ENTITY	Safety and immunogenicity of a candidate therapeutic vaccine , p24 virus-like particle , combined with zidovudine , in asymptomatic subjects .
10923603	0	zileuton	47,55	5-lipoxygenase	22,36	zileuton	5-lipoxygenase	MESH:C063449	240	Chemical	Gene	START_ENTITY|nsubj|Lack Lack|nmod|effect effect|nmod|inhibitor inhibitor|amod|END_ENTITY	Lack of effect of the 5-lipoxygenase inhibitor zileuton in blocking oral aspirin challenges in aspirin-sensitive asthmatics .
15475461	0	zileuton	102,110	5-lipoxygenase	18,32	zileuton	5-lipoxygenase	MESH:C063449	25290(Tax:10116)	Chemical	Gene	Overexpression|nmod|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of 5-lipoxygenase in rat and human esophageal_adenocarcinoma and inhibitory effects of zileuton and celecoxib on carcinogenesis .
15756036	0	zileuton	118,126	5-lipoxygenase	18,32	zileuton	5-lipoxygenase	MESH:C063449	240	Chemical	Gene	Overexpression|nmod|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of 5-lipoxygenase and cyclooxygenase_2 in hamster and human oral_cancer and chemopreventive effects of zileuton and celecoxib .
1618602	0	zileuton	33,41	5-lipoxygenase	60,74	zileuton	5-lipoxygenase	MESH:C063449	240	Chemical	Gene	discovery|nmod|START_ENTITY discovery|dep|orally orally|dep|inhibitor inhibitor|amod|END_ENTITY	The discovery and development of zileuton : an orally active 5-lipoxygenase inhibitor .
1781415	0	zileuton	75,83	5-lipoxygenase	101,115	zileuton	5-lipoxygenase	MESH:C063449	240	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Pharmacokinetics , safety , and ability to diminish leukotriene synthesis by zileuton , an inhibitor of 5-lipoxygenase .
1848634	0	zileuton	38,46	5-lipoxygenase	0,14	zileuton	5-lipoxygenase	MESH:C063449	25290(Tax:10116)	Chemical	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	5-lipoxygenase inhibitory activity of zileuton .
19309543	0	zileuton	25,33	5-lipoxygenase	0,14	zileuton	5-lipoxygenase	MESH:C063449	25290(Tax:10116)	Chemical	Gene	attenuates|compound|START_ENTITY attenuates|amod|END_ENTITY	5-lipoxygenase inhibitor zileuton attenuates ischemic brain_damage : involvement of matrix_metalloproteinase_9 .
19781629	0	zileuton	32,40	5-lipoxygenase	44,58	zileuton	5-lipoxygenase	MESH:C063449	25290(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|appos|inhibitor inhibitor|amod|END_ENTITY	The cardioprotective effects of zileuton , a 5-lipoxygenase inhibitor , are mediated by COX-2 via activation of PKC delta .
20880396	0	zileuton	30,38	5-lipoxygenase	4,18	zileuton	5-lipoxygenase	MESH:C063449	240	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	The 5-lipoxygenase inhibitor , zileuton , suppresses prostaglandin biosynthesis by inhibition of arachidonic_acid release in macrophages .
24295266	0	zileuton	29,37	5-lipoxygenase	13,27	zileuton	5-lipoxygenase	MESH:C063449	11689(Tax:10090)	Chemical	Gene	prostate_cancer|amod|START_ENTITY prostate_cancer|amod|END_ENTITY	Inhibitor of 5-lipoxygenase , zileuton , suppresses prostate_cancer metastasis by upregulating E-cadherin and paxillin .
7783062	0	zileuton	17,25	5-lipoxygenase	45,59	zileuton	5-lipoxygenase	MESH:C063449	240	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	A pilot study of zileuton , a novel selective 5-lipoxygenase inhibitor , in patients with systemic_lupus_erythematosus .
8598621	0	zileuton	25,33	5-lipoxygenase	37,51	zileuton	5-lipoxygenase	MESH:C063449	240	Chemical	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Effect of treatment with zileuton , a 5-lipoxygenase inhibitor , in patients with asthma .
8621850	0	zileuton	66,74	5-lipoxygenase	40,54	zileuton	5-lipoxygenase	MESH:C063449	240	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	A controlled trial of the effect of the 5-lipoxygenase inhibitor , zileuton , on lung_inflammation produced by segmental antigen challenge in human beings .
8796377	0	zileuton	52,60	5-lipoxygenase	26,40	zileuton	5-lipoxygenase	MESH:C063449	25290(Tax:10116)	Chemical	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	The effect of a selective 5-lipoxygenase inhibitor , zileuton , on tissue damage in acute_colonic_inflammation in rats .
8984030	0	zileuton	31,39	5-lipoxygenase	53,67	zileuton	5-lipoxygenase	MESH:C063449	25290(Tax:10116)	Chemical	Gene	administration|nmod|START_ENTITY administration|appos|inhibitor inhibitor|amod|END_ENTITY	Intracolonic administration of zileuton , a selective 5-lipoxygenase inhibitor , accelerates healing in a rat model of chronic_colitis .
9603138	0	zileuton	44,52	5-lipoxygenase	15,29	zileuton	5-lipoxygenase	MESH:C063449	240	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|inhibition inhibition|amod|END_ENTITY	The effects of 5-lipoxygenase inhibition by zileuton on platelet-activating-factor-induced pulmonary_abnormalities in mild asthma .
19781629	0	zileuton	32,40	COX-2	86,91	zileuton	COX-2	MESH:C063449	26198(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY mediated|nsubjpass|effects mediated|nmod|END_ENTITY	The cardioprotective effects of zileuton , a 5-lipoxygenase inhibitor , are mediated by COX-2 via activation of PKC delta .
16343285	0	zilpaterol	59,69	TNF-alpha	103,112	zilpaterol	TNF-alpha	MESH:C475840	24835(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	Inhibitory effects of the beta-adrenergic receptor agonist zilpaterol on the LPS-induced production of TNF-alpha in vitro and in vivo .
116266	0	zimelidine	11,21	prolactin	67,76	zimelidine	prolactin	MESH:D015031	5617	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|compound|END_ENTITY	Effects of zimelidine , a selective 5-HT uptake inhibitor , on serum prolactin levels in man .
3207614	0	zinc	58,62	5_alpha-reductase	14,31	zinc	5 alpha-reductase	MESH:D015032	6715	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activity activity|amod|END_ENTITY	Inhibition of 5_alpha-reductase activity in human skin by zinc and azelaic_acid .
8480682	0	zinc	35,39	A-II	59,63	zinc	A-II	MESH:D015032	114548	Chemical	Gene	association|nmod|START_ENTITY END_ENTITY|nsubj|association	Positive association between serum zinc and apolipoprotein A-II concentrations in middle-aged males who regularly consume alcohol .
11319609	0	zinc	4,8	A20	0,3	zinc	A20	MESH:D015032	7128	Chemical	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	A20 zinc finger protein inhibits TNF-induced apoptosis and stress response early in the signaling cascades and independently of binding to TRAF2 or 14-3-3 proteins .
11389905	0	zinc	29,33	A20	45,48	zinc	A20	MESH:D015032	7128	Chemical	Gene	fingers|compound|START_ENTITY fingers|nmod|END_ENTITY	Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappaB activation and protein-protein interactions .
18366681	0	zinc	12,16	A20	67,70	zinc	A20	MESH:D015032	21929(Tax:10090)	Chemical	Gene	protein|compound|START_ENTITY Design|nmod|protein binding|nsubj|Design binding|nmod|gene gene|compound|END_ENTITY	Design of a zinc finger protein binding a sequence upstream of the A20 gene .
2118515	0	zinc	76,80	A20	4,7	zinc	A20	MESH:D015032	7128	Chemical	Gene	protein|compound|START_ENTITY type|nmod|protein encodes|dobj|type encodes|nsubj|cDNA cDNA|compound|END_ENTITY	The A20 cDNA induced by tumor_necrosis_factor_alpha encodes a novel type of zinc finger protein .
23032186	0	zinc	92,96	A20	0,3	zinc	A20	MESH:D015032	7128	Chemical	Gene	finger|compound|START_ENTITY chains|nmod|finger inhibits|nmod|chains inhibits|nsubj|END_ENTITY	A20 inhibits LUBAC-mediated NF-kB activation by binding linear polyubiquitin chains via its zinc finger 7 .
23032187	0	zinc	52,56	A20	48,51	zinc	A20	MESH:D015032	28935	Chemical	Gene	finger|compound|START_ENTITY finger|compound|END_ENTITY	Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-kB regulation .
25911380	0	zinc	12,16	A20	33,36	zinc	A20	MESH:D015032	7128	Chemical	Gene	motif|compound|START_ENTITY motif|nmod|END_ENTITY	The seventh zinc finger motif of A20 is required for the suppression of TNF-a-induced apoptosis .
7539000	0	zinc	68,72	A20	55,58	zinc	A20	MESH:D015032	28935	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	Activation of the B-cell surface receptor CD40 induces A20 , a novel zinc finger protein that inhibits apoptosis .
8692885	0	zinc	36,40	A20	56,59	zinc	A20	MESH:D015032	7128	Chemical	Gene	interacts|compound|START_ENTITY interacts|compound|END_ENTITY	The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation .
1588970	0	zinc	17,21	ADR1	33,37	zinc	ADR1	MESH:D015032	851802(Tax:4932)	Chemical	Gene	fingers|compound|START_ENTITY fingers|nmod|END_ENTITY	Mutations in the zinc fingers of ADR1 that change the specificity of DNA binding and transactivation .
19021548	0	zinc	13,17	Albumin	0,7	zinc	Albumin	MESH:D015032	213	Chemical	Gene	carrier|compound|START_ENTITY END_ENTITY|nmod|carrier	Albumin as a zinc carrier : properties of its high-affinity zinc-binding site .
11279605	0	zinc	30,34	Aminopeptidase_N	0,16	zinc	Aminopeptidase N	MESH:D015032	290	Chemical	Gene	regulated|nmod|START_ENTITY END_ENTITY|acl|regulated	Aminopeptidase_N regulated by zinc in human prostate participates in tumor cell invasion .
21223390	0	zinc	23,27	AtTZF1	43,49	zinc	AtTZF1	MESH:D015032	817131(Tax:3702)	Chemical	Gene	finger|compound|START_ENTITY finger|dep|END_ENTITY	The Arabidopsis tandem zinc finger protein AtTZF1 affects ABA - and GA-mediated growth , stress and gene expression responses .
24635033	0	zinc	32,36	AtTZF1	47,53	zinc	AtTZF1	MESH:D015032	817131(Tax:3702)	Chemical	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	The Arabidopsis_thaliana tandem zinc finger 1 -LRB- AtTZF1 -RRB- protein in RNA binding and decay .
11352661	0	zinc	67,71	BCL-6	107,112	zinc	BCL-6	MESH:D015032	604	Chemical	Gene	protein|compound|START_ENTITY protein|acl|sharing sharing|nmod|END_ENTITY	Identification and characterization of DPZF , a novel human BTB/POZ zinc finger protein sharing homology to BCL-6 .
8235596	0	zinc	17,21	BCL-6	44,49	zinc	BCL-6	MESH:D015032	604	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Alterations of a zinc finger-encoding gene , BCL-6 , in diffuse_large-cell_lymphoma .
25585900	0	zinc	25,29	BCL6	41,45	zinc	BCL6	MESH:D015032	604	Chemical	Gene	fingers|compound|START_ENTITY fingers|nmod|END_ENTITY	Absence of the first two zinc fingers in BCL6 causes the loss of inhibitory effects on cell growth .
7935395	0	zinc	30,34	BZP	0,3	zinc	BZP	MESH:D015032	21417(Tax:10090)	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	BZP , a novel serum-responsive zinc finger protein that inhibits gene transcription .
25552313	0	zinc	73,77	C-Reactive_Protein	40,58	zinc	C-Reactive Protein	MESH:D015032	1401	Chemical	Gene	ions|compound|START_ENTITY stabilized|nmod|ions stabilized|nsubj|assembly assembly|nmod|END_ENTITY	A staggered decameric assembly of human C-Reactive_Protein stabilized by zinc ions revealed by X-ray crystallography .
7891685	0	zinc	12,16	CAT8	0,4	zinc	CAT8	MESH:D015032	855323(Tax:4932)	Chemical	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	CAT8 , a new zinc cluster-encoding gene necessary for derepression of gluconeogenic enzymes in the yeast Saccharomyces_cerevisiae .
10669742	0	zinc	7,11	CIZ	0,3	zinc	CIZ	MESH:D015032	171017	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	CIZ , a zinc finger protein that interacts with p130 -LRB- cas -RRB- and activates the expression of matrix metalloproteinases .
14656128	0	zinc	92,96	CO2	12,15	zinc	CO2	MESH:D015032	717	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	New role of CO2 as a selective agent in palladium-catalyzed reductive Ullmann coupling with zinc in water .
11706010	0	zinc	44,48	CTCF	39,43	zinc	CTCF	MESH:D015032	10664	Chemical	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	A region to the N-terminal side of the CTCF zinc finger domain is essential for activating transcription from the amyloid precursor protein promoter .
20177458	0	zinc	55,59	Catalase	0,8	zinc	Catalase	MESH:D015032	24248(Tax:10116)	Chemical	Gene	diet|compound|START_ENTITY fed|dobj|diet fed|nsubj|END_ENTITY	Catalase in testes and epididymidis of wistar_rats fed zinc deficient diet .
18081865	0	zinc	34,38	Ciz1	0,4	zinc	Ciz1	MESH:D015032	25792	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	Ciz1 , a p21_cip1 / Waf1-interacting zinc finger protein and DNA replication factor , is a novel molecular partner for human enhancer of rudimentary homolog .
12937164	0	zinc	15,19	ClpX	38,42	zinc	ClpX	MESH:D015032	10845	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	The N-terminal zinc binding domain of ClpX is a dimerization domain that modulates the chaperone function .
17258768	0	zinc	49,53	ClpX	72,76	zinc	ClpX	MESH:D015032	10845	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Structural basis of SspB-tail recognition by the zinc binding domain of ClpX .
1407754	0	zinc	58,62	Cysteine-rich_intestinal_protein	0,32	zinc	Cysteine-rich intestinal protein	MESH:D015032	1396	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|dep|protein	Cysteine-rich_intestinal_protein -LRB- CRIP -RRB- : a new intestinal zinc transport protein .
1729476	0	zinc	115,119	Cysteine-rich_intestinal_protein	0,32	zinc	Cysteine-rich intestinal protein	MESH:D015032	691657(Tax:10116)	Chemical	Gene	absorption|compound|START_ENTITY model|nmod|absorption relationship|nmod|model metallothionein|dep|relationship metallothionein|amod|END_ENTITY	Cysteine-rich_intestinal_protein and intestinal metallothionein : an inverse relationship as a conceptual model for zinc absorption in rats .
1946385	0	zinc	39,43	Cysteine-rich_intestinal_protein	0,32	zinc	Cysteine-rich intestinal protein	MESH:D015032	691657(Tax:10116)	Chemical	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Cysteine-rich_intestinal_protein binds zinc during transmucosal zinc transport .
1946385	0	zinc	64,68	Cysteine-rich_intestinal_protein	0,32	zinc	Cysteine-rich intestinal protein	MESH:D015032	691657(Tax:10116)	Chemical	Gene	transport|compound|START_ENTITY binds|nmod|transport binds|nsubj|END_ENTITY	Cysteine-rich_intestinal_protein binds zinc during transmucosal zinc transport .
9776738	0	zinc	27,31	DNA_ligase_III	12,26	zinc	DNA ligase III	MESH:D015032	3980	Chemical	Gene	finger|compound|START_ENTITY finger|compound|END_ENTITY	Role of the DNA_ligase_III zinc finger in polynucleotide binding and ligation .
21515579	0	zinc	6,10	Dal81	28,33	zinc	Dal81	MESH:D015032	854841(Tax:4932)	Chemical	Gene	proteins|compound|START_ENTITY proteins|dep|END_ENTITY	Yeast zinc cluster proteins Dal81 and Uga3 cooperate by targeting common coactivators for transcriptional activation of y-aminobutyrate responsive genes .
12117814	0	zinc	15,19	Drumstick	0,9	zinc	Drumstick	MESH:D015032	49638(Tax:7227)	Chemical	Gene	protein|compound|START_ENTITY protein|nsubj|END_ENTITY	Drumstick is a zinc finger protein that antagonizes Lines to control patterning and morphogenesis of the Drosophila hindgut .
14965266	5	zinc	698,702	EGR-1	650,655	zinc	EGR-1	MESH:D015032	1958	Chemical	Gene	fingers|compound|START_ENTITY subtype|nsubj|fingers contains|xcomp|subtype protein|acl:relcl|contains protein|nsubj|product product|appos|END_ENTITY	The Egr-1 gene product , EGR-1 , is a nuclear protein that contains three zinc fingers of the C -LRB- 2 -RRB- H -LRB- 2 -RRB- subtype .
15181171	0	zinc	127,131	EGR-1	160,165	zinc	EGR-1	MESH:D015032	1958	Chemical	Gene	factor|compound|START_ENTITY END_ENTITY|nsubj|factor	Inhibition of human breast_carcinoma proliferation , migration , _ chemoinvasion_and_solid_tumour growth by DNAzymes targeting the zinc finger transcription factor EGR-1 .
2064996	0	zinc	38,42	EGR-1	59,64	zinc	EGR-1	MESH:D015032	1958	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Posttranscriptional regulation of the zinc finger-encoding EGR-1 gene by granulocyte-macrophage_colony-stimulating_factor in human U-937 monocytic_leukemia cells : involvement of a pertussis toxin-sensitive G protein .
2244209	0	zinc	34,38	EGR-1	61,66	zinc	EGR-1	MESH:D015032	1958	Chemical	Gene	protein|compound|START_ENTITY protein|nmod|sequence sequence|compound|END_ENTITY	Binding of the Wilms ' _ tumor locus zinc finger protein to the EGR-1 consensus sequence .
8754857	0	zinc	73,77	EGR1	116,120	zinc	EGR1	MESH:D015032	13653(Tax:10090)	Chemical	Gene	NGFI-A|compound|START_ENTITY NGFI-A|appos|END_ENTITY	Unimpaired macrophage differentiation and activation in mice lacking the zinc finger transplantation factor NGFI-A -LRB- EGR1 -RRB- .
21035435	0	zinc	12,16	ERK	95,98	zinc	ERK	MESH:D015032	5594	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|END_ENTITY	Trace metal zinc stimulates secretion of antimicrobial peptide LL-37 from Caco-2 cells through ERK and p38 MAP kinase .
9794230	0	zinc	54,58	EVI-1	45,50	zinc	EVI-1	MESH:D015032	14013(Tax:10090)	Chemical	Gene	oncoprotein|compound|START_ENTITY Identification|appos|oncoprotein Identification|nmod|genes genes|nmod|END_ENTITY	Identification of candidate target genes for EVI-1 , a zinc finger oncoprotein , using a novel selection strategy .
18606452	0	zinc	5,9	Early_B_cell_Factor	28,47	zinc	Early B cell Factor	MESH:D015032	1879	Chemical	Gene	motif|compound|START_ENTITY motif|nmod|END_ENTITY	The ` zinc knuckle ' motif of Early_B_cell_Factor is required for transcriptional activation of B cell-specific genes .
19692582	0	zinc	4,8	Eco1	19,23	zinc	Eco1	MESH:D015032	114799	Chemical	Gene	finger|compound|START_ENTITY finger|nmod|END_ENTITY	The zinc finger of Eco1 enhances its acetyltransferase activity during sister chromatid cohesion .
10532946	0	zinc	34,38	Egr-1	81,86	zinc	Egr-1	MESH:D015032	1958	Chemical	Gene	factor|compound|START_ENTITY activation|nmod|factor BTEB2|nsubj|activation BTEB2|nmod|END_ENTITY	Transcriptional activation of the zinc finger transcription factor BTEB2 gene by Egr-1 through mitogen-activated protein kinase pathways in vascular smooth muscle cells .
11535237	0	zinc	89,93	Egr-1	80,85	zinc	Egr-1	MESH:D015032	1958	Chemical	Gene	factor|compound|START_ENTITY END_ENTITY|appos|factor	Epidermal_growth_factor and platelet-derived growth factor induce expression of Egr-1 , a zinc finger transcription factor , in human malignant_glioma cells .
11835312	0	zinc	116,120	Egr-1	107,112	zinc	Egr-1	MESH:D015032	1958	Chemical	Gene	factor|compound|START_ENTITY END_ENTITY|appos|factor	Nitric_oxide-induced programmed cell death in human neuroblastoma cells is accompanied by the synthesis of Egr-1 , a zinc finger transcription factor .
11948693	0	zinc	135,139	Egr-1	126,131	zinc	Egr-1	MESH:D015032	1958	Chemical	Gene	regulator|compound|START_ENTITY END_ENTITY|appos|regulator	Epidermal_growth_factor and thrombin induced proliferation of immortalized human keratinocytes is coupled to the synthesis of Egr-1 , a zinc finger transcriptional regulator .
15910736	1	zinc	241,245	Egr-1	232,237	zinc	Egr-1	MESH:D015032	1958	Chemical	Gene	factor|compound|START_ENTITY END_ENTITY|appos|factor	Activation of extracellular_signal-regulated_protein_kinase -LRB- ERK -RRB- triggers the biosynthesis of Egr-1 , a zinc finger transcription factor .
2109185	0	zinc	77,81	Egr-1	43,48	zinc	Egr-1	MESH:D015032	24330(Tax:10116)	Chemical	Gene	protein|compound|START_ENTITY product|appos|protein product|compound|END_ENTITY	Identification and characterization of the Egr-1 gene product , a DNA-binding zinc finger protein induced by differentiation and growth signals .
22675124	0	zinc	22,26	Egr-1	105,110	zinc	Egr-1	MESH:D015032	1958	Chemical	Gene	fingers|compound|START_ENTITY roles|nmod|fingers process|nsubj|roles process|nmod|END_ENTITY	Asymmetrical roles of zinc fingers in dynamic DNA-scanning process by the inducible transcription factor Egr-1 .
3140220	0	zinc	80,84	Egr-1	46,51	zinc	Egr-1	MESH:D015032	13653(Tax:10090)	Chemical	Gene	finger|compound|START_ENTITY inducible|dobj|finger inducible|nsubj|sequence sequence|nmod|END_ENTITY	5 ' flanking sequence and genomic structure of Egr-1 , a murine mitogen inducible zinc finger encoding gene .
9322954	0	zinc	80,84	Egr-1	122,127	zinc	Egr-1	MESH:D015032	24330(Tax:10116)	Chemical	Gene	finger|compound|START_ENTITY specific|nmod|finger factors|amod|specific factors|amod|END_ENTITY	Regulation of osteoclastogenesis by antisense oligodeoxynucleotides specific to zinc finger nuclear transcription factors Egr-1 and WT1 in rat bone marrow culture system .
9418958	0	zinc	31,35	Egr-1	70,75	zinc	Egr-1	MESH:D015032	13653(Tax:10090)	Chemical	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	Differential regulation of the zinc finger genes Krox-20 and Krox-24 -LRB- Egr-1 -RRB- suggests antagonistic roles in Schwann cells .
11535237	0	zinc	89,93	Epidermal_growth_factor	0,23	zinc	Epidermal growth factor	MESH:D015032	1950	Chemical	Gene	factor|compound|START_ENTITY Egr-1|appos|factor expression|nmod|Egr-1 induce|dobj|expression induce|nsubj|END_ENTITY	Epidermal_growth_factor and platelet-derived growth factor induce expression of Egr-1 , a zinc finger transcription factor , in human malignant_glioma cells .
11948693	0	zinc	135,139	Epidermal_growth_factor	0,23	zinc	Epidermal growth factor	MESH:D015032	1950	Chemical	Gene	regulator|compound|START_ENTITY Egr-1|appos|regulator synthesis|nmod|Egr-1 coupled|nmod|synthesis coupled|nsubjpass|proliferation proliferation|compound|END_ENTITY	Epidermal_growth_factor and thrombin induced proliferation of immortalized human keratinocytes is coupled to the synthesis of Egr-1 , a zinc finger transcriptional regulator .
20809125	0	zinc	27,31	ErbB2	41,46	zinc	ErbB2	MESH:D015032	24337(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY requires|nsubj|effect requires|dobj|END_ENTITY	Cardioprotective effect of zinc requires ErbB2 and Akt during hypoxia/reoxygenation .
1370341	0	zinc	24,28	Evi-1	18,23	zinc	Evi-1	MESH:D015032	14013(Tax:10090)	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Expression of the Evi-1 zinc finger gene in 32Dc13 myeloid cells blocks granulocytic differentiation in response to granulocyte_colony-stimulating_factor .
1699199	0	zinc	10,14	Evi-1	4,9	zinc	Evi-1	MESH:D015032	2122	Chemical	Gene	finger|compound|START_ENTITY finger|compound|END_ENTITY	The Evi-1 zinc finger myeloid transforming gene is normally expressed in the kidney and in developing oocytes .
2017172	0	zinc	16,20	Evi-1	0,5	zinc	Evi-1	MESH:D015032	14013(Tax:10090)	Chemical	Gene	proto-oncogene|compound|START_ENTITY END_ENTITY|appos|proto-oncogene	Evi-1 , a murine zinc finger proto-oncogene , encodes a sequence-specific DNA-binding protein .
2113669	0	zinc	34,38	Evi-1	28,33	zinc	Evi-1	MESH:D015032	2122	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Alternative splicing of the Evi-1 zinc finger gene generates mRNAs which differ by the number of zinc finger motifs .
2113669	0	zinc	97,101	Evi-1	28,33	zinc	Evi-1	MESH:D015032	2122	Chemical	Gene	motifs|compound|START_ENTITY number|nmod|motifs differ|nmod|number mRNAs|acl:relcl|differ generates|dobj|mRNAs generates|nsubj|splicing splicing|nmod|gene gene|compound|END_ENTITY	Alternative splicing of the Evi-1 zinc finger gene generates mRNAs which differ by the number of zinc finger motifs .
7624127	0	zinc	10,14	Evi-1	4,9	zinc	Evi-1	MESH:D015032	2122	Chemical	Gene	finger|compound|START_ENTITY finger|compound|END_ENTITY	The Evi-1 zinc finger myeloid transforming protein binds to genomic fragments containing -LRB- GATA -RRB- n sequences .
8183551	0	zinc	23,27	Evi-1	43,48	zinc	Evi-1	MESH:D015032	2122	Chemical	Gene	fingers|compound|START_ENTITY fingers|nmod|END_ENTITY	The carboxyl domain of zinc fingers of the Evi-1 myeloid transforming gene binds a consensus sequence of GAAGATGAG .
8321231	0	zinc	18,22	Evi-1	38,43	zinc	Evi-1	MESH:D015032	2122	Chemical	Gene	fingers|compound|START_ENTITY fingers|nmod|gene gene|amod|END_ENTITY	Four of the seven zinc fingers of the Evi-1 myeloid-transforming gene are required for sequence-specific binding to GA -LRB- C/T -RRB- AAGA -LRB- T/C -RRB- AAGATAA .
1448096	0	zinc	36,40	FTZ-F1	90,96	zinc	FTZ-F1	MESH:D015032	26423(Tax:10090)	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	A novel DNA-binding motif abuts the zinc finger domain of insect nuclear hormone receptor FTZ-F1 and mouse embryonal_long_terminal_repeat-binding_protein .
10781957	0	zinc	34,38	Fez	52,55	zinc	Fez	MESH:D015032	398172(Tax:8355)	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Cloning and expression of a novel zinc finger gene , Fez , transcribed in the forebrain of Xenopus and mouse embryos .
15067362	0	zinc	17,21	Finb	0,4	zinc	Finb	MESH:D015032	6239	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	Finb , a multiple zinc finger protein , represses transcription of the human angiotensinogen gene .
10409713	0	zinc	14,18	Fiz1	0,4	zinc	Fiz1	MESH:D015032	23877(Tax:10090)	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	Fiz1 , a novel zinc finger protein interacting with the receptor_tyrosine_kinase Flt3 .
11318609	0	zinc	32,36	Fliz1	15,20	zinc	Fliz1	MESH:D015032	57432(Tax:10090)	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	Transcripts of Fliz1 , a nuclear zinc finger protein , are expressed in discrete foci of the murine fetal liver .
8610125	0	zinc	21,25	GAGA	47,51	zinc	GAGA	MESH:D015032	2768981(Tax:7227)	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|protein protein|compound|END_ENTITY	The single Cys2-His2 zinc finger domain of the GAGA protein flanked by basic residues is sufficient for high-affinity specific DNA binding .
2018497	0	zinc	59,63	GAL4	53,57	zinc	GAL4	MESH:D015032	855828(Tax:4932)	Chemical	Gene	finger|compound|START_ENTITY finger|compound|END_ENTITY	Spectroscopic studies of the DNA binding site of the GAL4 `` zinc finger '' protein .
18621058	0	zinc	36,40	GATA	31,35	zinc	GATA	MESH:D015032	76563(Tax:10090)	Chemical	Gene	fingers|compound|START_ENTITY fingers|compound|END_ENTITY	Crystal structures of multiple GATA zinc fingers bound to DNA reveal new insights into DNA recognition and self-association by GATA .
10212985	0	zinc	41,45	GATA-1	56,62	zinc	GATA-1	MESH:D015032	396450(Tax:9031)	Chemical	Gene	finger|compound|START_ENTITY finger|nmod|END_ENTITY	The solution structure of the N-terminal zinc finger of GATA-1 reveals a specific binding face for the transcriptional co-factor FOG .
11445591	0	zinc	15,19	GATA-1	65,71	zinc	GATA-1	MESH:D015032	2623	Chemical	Gene	finger|compound|START_ENTITY finger|nmod|END_ENTITY	The N-terminal zinc finger of the erythroid transcription factor GATA-1 binds GATC motifs in DNA .
7823932	0	zinc	15,19	GATA-1	30,36	zinc	GATA-1	MESH:D015032	2623	Chemical	Gene	finger|compound|START_ENTITY finger|nmod|END_ENTITY	The C-terminal zinc finger of GATA-1 or GATA-2 is sufficient to induce megakaryocytic differentiation of an early myeloid cell line .
8262042	0	zinc	8,12	GATA-1	36,42	zinc	GATA-1	MESH:D015032	2623	Chemical	Gene	domains|compound|START_ENTITY domains|nmod|END_ENTITY	The two zinc finger-like domains of GATA-1 have different DNA binding specificities .
26660446	0	zinc	88,92	GATA-2	70,76	zinc	GATA-2	MESH:D015032	14461(Tax:10090)	Chemical	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	Loss of c-kit and bone_marrow_failure upon conditional removal of the GATA-2 C-terminal zinc finger domain in adult mice .
24371770	0	zinc	6,10	GATA2	0,5	zinc	GATA2	MESH:D015032	2624	Chemical	Gene	finger|compound|START_ENTITY finger|compound|END_ENTITY	GATA2 zinc finger 2 mutation found in acute_myeloid_leukemia impairs myeloid differentiation .
23426817	0	zinc	20,24	GH	52,54	zinc	GH	MESH:D015032	2688	Chemical	Gene	effects|nmod|START_ENTITY supplementation|nsubj|effects supplementation|nmod|END_ENTITY	Positive effects of zinc supplementation on growth , GH , IGF1 , and IGFBP3 in eutrophic children .
16982049	0	zinc	15,19	GLP-1	0,5	zinc	GLP-1	MESH:D015032	100009600(Tax:10090)	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|dep|protein	GLP-1 : a novel zinc finger protein required in somatic cells of the gonad for germ cell development .
16959833	0	zinc	33,37	GPR39	0,5	zinc	GPR39	MESH:D015032	71111(Tax:10090)	Chemical	Gene	ions|compound|START_ENTITY stimulated|nmod|ions stimulated|nsubjpass|signaling signaling|compound|END_ENTITY	GPR39 signaling is stimulated by zinc ions but not by obestatin .
23089648	0	zinc	34,38	GPR39	16,21	zinc	GPR39	MESH:D015032	2863	Chemical	Gene	deficient-animal_model_of_depression|compound|START_ENTITY role|nmod|deficient-animal_model_of_depression role|nmod|receptor receptor|compound|END_ENTITY	The role of the GPR39 receptor in zinc deficient-animal_model_of_depression .
25827929	0	zinc	40,44	GPR39	33,38	zinc	GPR39	MESH:D015032	71111(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|dep|receptor	Study of antidepressant drugs in GPR39 -LRB- zinc receptor -LRB- - / - -RRB- -RRB- knockout mice , showing no effect of conventional antidepressants , but effectiveness of NMDA antagonists .
25827929	0	zinc	40,44	GPR39	33,38	zinc	GPR39	MESH:D015032	71111(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|dep|receptor	Study of antidepressant drugs in GPR39 -LRB- zinc receptor -LRB- - / - -RRB- -RRB- knockout mice , showing no effect of conventional antidepressants , but effectiveness of NMDA antagonists .
25917396	0	zinc	27,31	GPR39	21,26	zinc	GPR39	MESH:D015032	71111(Tax:10090)	Chemical	Gene	inhibition|compound|START_ENTITY inhibition|compound|END_ENTITY	Investigation of the GPR39 zinc receptor following inhibition of monoaminergic neurotransmission and potentialization of glutamatergic neurotransmission .
26365466	0	zinc	4,8	GPR39	26,31	zinc	GPR39	MESH:D015032	2863	Chemical	Gene	receptor|compound|START_ENTITY END_ENTITY|nsubj|receptor	The zinc binding receptor GPR39 interacts with 5-HT1A and GalR1 to form dynamic heteroreceptor complexes with signaling diversity .
26857489	0	zinc	32,36	GPR39	26,31	zinc	GPR39	MESH:D015032	71111(Tax:10090)	Chemical	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Immune malfunction in the GPR39 zinc receptor of knockout mice : Its relationship to depressive_disorder .
18328814	0	zinc	82,86	Gata-1	75,81	zinc	Gata-1	MESH:D015032	396450(Tax:9031)	Chemical	Gene	finger|compound|START_ENTITY finger|compound|END_ENTITY	Substitution of DNA-contacting amino_acids with functional variants in the Gata-1 zinc finger : a structurally and phylogenetically guided mutagenesis .
20153336	0	zinc	28,32	Gfi-1	22,27	zinc	Gfi-1	MESH:D015032	2672	Chemical	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	Solution structure of Gfi-1 zinc domain bound to consensus DNA .
12351384	0	zinc	43,47	Gfi-1B	36,42	zinc	Gfi-1B	MESH:D015032	8328	Chemical	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Erythroid expansion mediated by the Gfi-1B zinc finger protein : role in normal hematopoiesis .
20564420	0	zinc	65,69	HIF-1alpha	46,56	zinc	HIF-1alpha	MESH:D015032	3091	Chemical	Gene	toxicity|compound|START_ENTITY END_ENTITY|nmod|toxicity	Survivin mediates prostate cell protection by HIF-1alpha against zinc toxicity .
9813242	0	zinc	18,22	HKR1	43,47	zinc	HKR1	MESH:D015032	284459	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The Kr ppel-type zinc finger family gene , HKR1 , is induced in lung_cancer by exposure to platinum drugs .
15496404	0	zinc	17,21	Hsp40	11,16	zinc	Hsp40	MESH:D015032	855661(Tax:4932)	Chemical	Gene	region|compound|START_ENTITY region|compound|END_ENTITY	The type I Hsp40 zinc finger-like region is required for Hsp70 to capture non-native polypeptides from Ydj1 .
20662514	0	zinc	26,30	HypA	59,63	zinc	HypA	MESH:D015032	55660	Chemical	Gene	sites|compound|START_ENTITY sites|nmod|END_ENTITY	Communication between the zinc and nickel sites in dimeric HypA : metal recognition and pH sensing .
15020707	0	zinc	44,48	ID1	10,13	zinc	ID1	MESH:D015032	541693(Tax:4577)	Chemical	Gene	protein|compound|START_ENTITY protein|nsubj|END_ENTITY	The maize ID1 flowering time regulator is a zinc finger protein with novel DNA binding properties .
18207244	0	zinc	17,21	IKK_gamma	39,48	zinc	IKK gamma	MESH:D015032	8517	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Mutations in the zinc finger domain of IKK_gamma block the activation of NF-kappa_B and the induction of IL-2 in stimulated T lymphocytes .
13377658	0	zinc	8,12	Insulin	0,7	zinc	Insulin	MESH:D015032	3630	Chemical	Gene	suspension|compound|START_ENTITY suspension|compound|END_ENTITY	Insulin zinc suspension ; four years ' experience .
6134471	0	zinc	48,52	Insulin	0,7	zinc	Insulin	MESH:D015032	483665(Tax:9615)	Chemical	Gene	excretion|compound|START_ENTITY inhibitor|nmod|excretion inhibitor|nsubj|END_ENTITY	Insulin is a physiological inhibitor of urinary zinc excretion in anesthetized dogs .
84149	0	zinc	25,29	Insulin	1,8	zinc	Insulin	MESH:D015032	3630	Chemical	Gene	due|nmod|START_ENTITY allergy|xcomp|due allergy|nsubj|END_ENTITY	`` Insulin '' allergy due to zinc .
19592062	0	zinc	4,8	K-RBP	38,43	zinc	K-RBP	MESH:D015032	79088	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	The zinc finger DNA-binding domain of K-RBP plays an important role in regulating Kaposi 's _ sarcoma-associated_herpesvirus RTA-mediated gene expression .
12001065	0	zinc	49,53	KRC	69,72	zinc	KRC	MESH:D015032	16656(Tax:10090)	Chemical	Gene	protein|compound|START_ENTITY expression|nmod|protein END_ENTITY|nsubj|expression	Embryonic expression and regulation of the large zinc finger protein KRC .
7937163	0	zinc	23,27	Kin17	0,5	zinc	Kin17	MESH:D015032	16588(Tax:10090)	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	Kin17 , a mouse nuclear zinc finger protein that binds preferentially to curved DNA .
9655926	0	zinc	20,24	Kzf1	0,4	zinc	Kzf1	MESH:D015032	25165(Tax:10116)	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|dep|protein	Kzf1 - a novel KRAB zinc finger protein encoding gene expressed during rat spermatogenesis .
17673939	0	zinc	44,48	LIV-1	25,30	zinc	LIV-1	MESH:D015032	25800	Chemical	Gene	subfamily|nmod|START_ENTITY subfamily|compound|END_ENTITY	The emerging role of the LIV-1 subfamily of zinc transporters in breast_cancer .
21035435	0	zinc	12,16	LL-37	63,68	zinc	LL-37	MESH:D015032	820	Chemical	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|nmod|END_ENTITY	Trace metal zinc stimulates secretion of antimicrobial peptide LL-37 from Caco-2 cells through ERK and p38 MAP kinase .
19617361	0	zinc	65,69	Lbp	28,31	zinc	Lbp	MESH:D015032	3929	Chemical	Gene	receptor|compound|START_ENTITY receptor|nsubj|END_ENTITY	The laminin-binding protein Lbp from Streptococcus_pyogenes is a zinc receptor .
2244921	0	zinc	28,32	Leukotriene_A4_hydrolase	0,24	zinc	Leukotriene A4 hydrolase	MESH:D015032	4048	Chemical	Gene	metalloenzyme|compound|START_ENTITY END_ENTITY|dep|metalloenzyme	Leukotriene_A4_hydrolase : a zinc metalloenzyme .
10409672	0	zinc	28,32	Lung_Kruppel-like_factor	0,24	zinc	Lung Kruppel-like factor	MESH:D015032	16598(Tax:10090)	Chemical	Gene	factor|compound|START_ENTITY END_ENTITY|appos|factor	Lung_Kruppel-like_factor , a zinc finger transcription factor , is essential for normal lung development .
1502157	0	zinc	7,11	MAZ	0,3	zinc	MAZ	MESH:D015032	4150	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	MAZ , a zinc finger protein , binds to c-MYC and C2 gene sequences regulating transcriptional initiation and termination .
11553631	0	zinc	23,27	MBD2	130,134	zinc	MBD2	MESH:D015032	8932	Chemical	Gene	protein|compound|START_ENTITY Involvement|nmod|protein END_ENTITY|nsubj|Involvement	Involvement of a novel zinc finger protein , MIZF , in transcriptional repression by interacting with a methyl-CpG-binding protein , MBD2 .
1567844	0	zinc	58,62	MBP-1	110,115	zinc	MBP-1	MESH:D015032	4153	Chemical	Gene	finger|compound|START_ENTITY finger|nmod|END_ENTITY	High-resolution solution structure of the double Cys2His2 zinc finger from the human enhancer binding protein MBP-1 .
11553631	0	zinc	23,27	MIZF	44,48	zinc	MIZF	MESH:D015032	25988	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Involvement of a novel zinc finger protein , MIZF , in transcriptional repression by interacting with a methyl-CpG-binding protein , MBD2 .
21669521	0	zinc	14,18	MMP13	41,46	zinc	MMP13	MESH:D015032	4322	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|nmod|END_ENTITY	Selective non zinc binding inhibitors of MMP13 .
15225875	0	zinc	41,45	MOVO	36,40	zinc	MOVO	MESH:D015032	107586(Tax:10090)	Chemical	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Characterization of the isoforms of MOVO zinc finger protein , a mouse homologue of Drosophila Ovo , as transcription factors .
19001415	0	zinc	19,23	MOZ	32,35	zinc	MOZ	MESH:D015032	244349(Tax:10090)	Chemical	Gene	finger|compound|START_ENTITY finger|appos|END_ENTITY	Monocytic_leukemia zinc finger -LRB- MOZ -RRB- interacts with p53 to induce p21 expression and cell-cycle arrest .
10556717	0	zinc	40,44	MPS1	0,4	zinc	MPS1	MESH:D015032	6232	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|dep|protein	MPS1 : a small , evolutionarily conserved zinc finger protein from the protozoan Toxoplasma_gondii .
11735399	0	zinc	84,88	MRE-binding_transcription_factor-1	100,134	zinc	MRE-binding transcription factor-1	MESH:D015032	4520	Chemical	Gene	fingers|compound|START_ENTITY fingers|nmod|END_ENTITY	Ratiometric pulsed alkylation/mass spectrometry of the cysteine pairs in individual zinc fingers of MRE-binding_transcription_factor-1 -LRB- MTF-1 -RRB- as a probe of zinc_chelate stability .
11056018	0	zinc	9,13	MTF-1	74,79	zinc	MTF-1	MESH:D015032	4520	Chemical	Gene	fingers|compound|START_ENTITY Roles|nmod|fingers Roles|nmod|END_ENTITY	Roles of zinc fingers and other regions of the transcription factor human MTF-1 in zinc-regulated DNA binding .
11230134	0	zinc	133,137	MTF-1	26,31	zinc	MTF-1	MESH:D015032	17764(Tax:10090)	Chemical	Gene	regulate|nmod|START_ENTITY cooperate|xcomp|regulate cooperate|nsubj|END_ENTITY	The transcription factors MTF-1 and USF1 cooperate to regulate mouse metallothionein-I expression in response to the essential metal zinc in visceral endoderm cells during early development .
11524427	0	zinc	47,51	MTF-1	69,74	zinc	MTF-1	MESH:D015032	4520	Chemical	Gene	fingers|compound|START_ENTITY fingers|nmod|END_ENTITY	Conformational heterogeneity in the C-terminal zinc fingers of human MTF-1 : an NMR and zinc-binding study .
11735399	0	zinc	84,88	MTF-1	136,141	zinc	MTF-1	MESH:D015032	4520	Chemical	Gene	fingers|compound|START_ENTITY fingers|nmod|MRE-binding_transcription_factor-1 MRE-binding_transcription_factor-1|appos|END_ENTITY	Ratiometric pulsed alkylation/mass spectrometry of the cysteine pairs in individual zinc fingers of MRE-binding_transcription_factor-1 -LRB- MTF-1 -RRB- as a probe of zinc_chelate stability .
11831458	0	zinc	9,13	MTF-1	23,28	zinc	MTF-1	MESH:D015032	17764(Tax:10090)	Chemical	Gene	sensors|compound|START_ENTITY sensors|dep|regulation regulation|compound|END_ENTITY	Cellular zinc sensors : MTF-1 regulation of gene expression .
11866436	0	zinc	50,54	MTF-1	83,88	zinc	MTF-1	MESH:D015032	195821(Tax:7955)	Chemical	Gene	finger|compound|START_ENTITY cloning|nmod|finger transcription|nsubj|cloning transcription|dobj|gene gene|compound|END_ENTITY	Molecular cloning and developmental expression of zinc finger transcription factor MTF-1 gene in zebrafish , Danio_rerio .
15318811	0	zinc	115,119	MTF-1	41,46	zinc	MTF-1	MESH:D015032	4520	Chemical	Gene	concentration|compound|START_ENTITY low|nmod|concentration selects|nmod|low selects|nsubj|Metal-responsive_transcription_factor-1 Metal-responsive_transcription_factor-1|appos|END_ENTITY	Metal-responsive_transcription_factor-1 -LRB- MTF-1 -RRB- selects different types of metal response elements at low vs. high zinc concentration .
16423564	0	zinc	110,114	MTF-1	89,94	zinc	MTF-1	MESH:D015032	4520	Chemical	Gene	release|compound|START_ENTITY mediated|nmod|release mediated|nsubjpass|translocation translocation|nmod|factor factor|appos|END_ENTITY	Nitric_oxide-induced nuclear translocation of the metal responsive transcription factor , MTF-1 is mediated by zinc release from metallothionein .
16847313	0	zinc	79,83	MTF-1	36,41	zinc	MTF-1	MESH:D015032	17764(Tax:10090)	Chemical	Gene	fingers|compound|START_ENTITY peptides|nmod|fingers involves|dobj|peptides involves|nsubj|mechanism mechanism|nmod|END_ENTITY	The zinc-sensing mechanism of mouse MTF-1 involves linker peptides between the zinc fingers .
26336656	0	zinc	58,62	MTF-1	41,46	zinc	MTF-1	MESH:D015032	4520	Chemical	Gene	dependent|advmod|START_ENTITY processes|amod|dependent regulates|dobj|processes regulates|nsubj|Metal_responsive_transcription_factor_1 Metal_responsive_transcription_factor_1|appos|END_ENTITY	Metal_responsive_transcription_factor_1 -LRB- MTF-1 -RRB- regulates zinc dependent cellular processes at the molecular level .
8929813	0	zinc	28,32	MTF-1	62,67	zinc	MTF-1	MESH:D015032	4520	Chemical	Gene	finger|compound|START_ENTITY sensitivity|nmod|finger transcription|nsubj|sensitivity transcription|xcomp|CpG CpG|dep|END_ENTITY	Differential sensitivity of zinc finger transcription factors MTF-1 , Sp1 and Krox-20 to CpG methylation of their binding sites .
1860835	0	zinc	33,37	MZF-1	51,56	zinc	MZF-1	MESH:D015032	7593	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A retinoic_acid-responsive human zinc finger gene , MZF-1 , preferentially expressed in myeloid cells .
7579328	0	zinc	12,16	MZF-1	30,35	zinc	MZF-1	MESH:D015032	7593	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The myeloid zinc finger gene , MZF-1 , regulates the CD34 promoter in vitro .
7627970	0	zinc	35,39	MZF-1	53,58	zinc	MZF-1	MESH:D015032	109889(Tax:10090)	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Aberrant expression of the myeloid zinc finger gene , MZF-1 , is oncogenic .
8585946	0	zinc	56,60	MZF-1	74,79	zinc	MZF-1	MESH:D015032	7593	Chemical	Gene	gene|compound|START_ENTITY transcriptional|nmod|gene transcriptional|xcomp|END_ENTITY	Hematopoietic transcriptional regulation by the myeloid zinc finger gene , MZF-1 .
9593266	0	zinc	12,16	MZF-1	30,35	zinc	MZF-1	MESH:D015032	7593	Chemical	Gene	gene|compound|START_ENTITY delays|compound|gene delays|appos|END_ENTITY	The myeloid zinc finger gene -LRB- MZF-1 -RRB- delays retinoic_acid-induced apoptosis and differentiation in myeloid_leukemia cells .
9593266	1	zinc	135,139	MZF-1	153,158	zinc	MZF-1	MESH:D015032	7593	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The myeloid zinc finger gene , MZF-1 , is a hematopoietic transcription factor expressed in developing myeloid cells .
12566070	0	zinc	32,36	Metallothionein_2A	0,18	zinc	Metallothionein 2A	MESH:D015032	4502	Chemical	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Metallothionein_2A induction by zinc protects HEPG2 cells against CYP2E1-dependent toxicity .
9256341	0	zinc	14,18	Miz1	0,4	zinc	Miz1	MESH:D015032	83422(Tax:10116)	Chemical	Gene	factor|compound|START_ENTITY END_ENTITY|appos|factor	Miz1 , a novel zinc finger transcription factor that interacts with Msx2 and enhances its affinity for DNA .
15277543	0	zinc	18,22	Msc2	13,17	zinc	Msc2	MESH:D015032	851786(Tax:4932)	Chemical	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	Zinc and the Msc2 zinc transporter protein are required for endoplasmic reticulum function .
8641288	0	zinc	29,33	Msn2p	50,55	zinc	Msn2p	MESH:D015032	855053(Tax:4932)	Chemical	Gene	proteins|nsubj|START_ENTITY proteins|acl:relcl|required required|nsubjpass|END_ENTITY	The Saccharomyces_cerevisiae zinc finger proteins Msn2p and Msn4p are required for transcriptional induction through the stress response element -LRB- STRE -RRB- .
8650168	0	zinc	9,13	Msn2p	0,5	zinc	Msn2p	MESH:D015032	855053(Tax:4932)	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	Msn2p , a zinc finger DNA-binding protein , is the transcriptional activator of the multistress response in Saccharomyces_cerevisiae .
9373037	0	zinc	103,107	Myelin_transcription_factor_1	0,29	zinc	Myelin transcription factor 1	MESH:D015032	4661	Chemical	Gene	along|nmod|START_ENTITY lineage|advmod|along END_ENTITY|nmod|lineage	Myelin_transcription_factor_1 -LRB- Myt1 -RRB- of the oligodendrocyte lineage , along with a closely related CCHC zinc finger , is expressed in developing neurons in the mammalian central nervous system .
12138192	0	zinc	4,8	NEMO	26,30	zinc	NEMO	MESH:D015032	8517	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	The zinc finger domain of NEMO is selectively required for NF-kappa_B activation by UV radiation and topoisomerase inhibitors .
18313693	0	zinc	27,31	NEMO	22,26	zinc	NEMO	MESH:D015032	8517	Chemical	Gene	START_ENTITY|nsubj|structure structure|nmod|END_ENTITY	Solution structure of NEMO zinc finger and impact of an anhidrotic_ectodermal_dysplasia with immunodeficiency-related point mutation .
19033441	0	zinc	4,8	NEMO	19,23	zinc	NEMO	MESH:D015032	8517	Chemical	Gene	finger|compound|START_ENTITY finger|nmod|END_ENTITY	The zinc finger of NEMO is a functional ubiquitin-binding domain .
20345847	0	zinc	4,8	NEMO	32,36	zinc	NEMO	MESH:D015032	8517	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|protein protein|appos|END_ENTITY	The zinc finger domain of IKKy -LRB- NEMO -RRB- protein in health and disease .
24100029	0	zinc	64,68	NEMO	58,62	zinc	NEMO	MESH:D015032	8517	Chemical	Gene	finger|compound|START_ENTITY unveiled|nsubj|finger unveiled|dep|END_ENTITY	Two-sided ubiquitin binding of NF-kB_essential_modulator -LRB- NEMO -RRB- zinc finger unveiled by a mutation associated with anhidrotic ectodermal_dysplasia with immunodeficiency_syndrome .
16905136	0	zinc	38,42	NF-X1	27,32	zinc	NF-X1	MESH:D015032	4799	Chemical	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	The AtNFXL1 gene encodes a NF-X1 type zinc finger protein required for growth under salt stress .
11389905	0	zinc	29,33	NF-kappaB	67,76	zinc	NF-kappaB	MESH:D015032	4790	Chemical	Gene	fingers|compound|START_ENTITY redundancy|nmod|fingers redundancy|nmod|activation activation|amod|END_ENTITY	Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappaB activation and protein-protein interactions .
16930873	0	zinc	16,20	NF-kappaB	24,33	zinc	NF-kappaB	MESH:D015032	4790	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Toxic effect of zinc on NF-kappaB , IL-2 , IL-2_receptor_alpha , and TNF-alpha in HUT-78 -LRB- Th -LRB- 0 -RRB- -RRB- cells .
17029595	0	zinc	107,111	NF-kappaB	30,39	zinc	NF-kappaB	MESH:D015032	4790	Chemical	Gene	modulation|nmod|START_ENTITY translocation|dep|modulation translocation|amod|END_ENTITY	Microtubules are required for NF-kappaB nuclear translocation in neuroblastoma IMR-32 cells : modulation by zinc .
9187268	3	zinc	509,513	NMDA	517,521	zinc	NR2A	MESH:D015032	2903	Chemical	Gene	START_ENTITY|nmod|receptors receptors|compound|END_ENTITY	To further investigate the modulatory effects of zinc on NMDA receptors of different subunit compositions , we coexpressed the recombinant subunit NR1 with NR2A and/or NR2B in HEK 293 cells .
21155258	0	zinc	12,16	NOS	32,35	zinc	NOS	MESH:D015032	18125(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	-LSB- Effects of zinc on activity of NOS and expression of nNOS in hippocampus of acute hypoxic mice -RSB- .
16166158	0	zinc	31,35	NR2A	69,73	zinc	NR2A	MESH:D015032	2903	Chemical	Gene	domains|compound|START_ENTITY domains|nmod|END_ENTITY	Allosteric interaction between zinc and glutamate binding domains on NR2A causes desensitization of NMDA receptors .
24820620	0	zinc	79,83	NZF-1	92,97	zinc	NZF-1	MESH:D015032	23040	Chemical	Gene	finger|compound|START_ENTITY finger|appos|END_ENTITY	A role for hydrogen bonding in DNA recognition by the non-classical CCHHC type zinc finger , NZF-1 .
23994011	0	zinc	34,38	Nab2p	49,54	zinc	Nab2p	MESH:D015032	4665	Chemical	Gene	finger|compound|START_ENTITY finger|nmod|END_ENTITY	Two singular types of CCCH tandem zinc finger in Nab2p contribute to polyadenosine RNA recognition .
11702779	0	zinc	4,8	OMA-1	26,31	zinc	OMA-1	MESH:D015032	177703(Tax:6239)	Chemical	Gene	proteins|compound|START_ENTITY proteins|amod|END_ENTITY	Two zinc finger proteins , OMA-1 and OMA-2 , are redundantly required for oocyte maturation in C. _ elegans .
19034670	0	zinc	38,42	OTK18	58,63	zinc	OTK18	MESH:D015032	7728	Chemical	Gene	activation|compound|START_ENTITY activation|nummod|END_ENTITY	YY1 and FoxD3 regulate antiretroviral zinc finger protein OTK18 promoter activation induced by HIV-1_infection .
11044622	0	zinc	13,17	Opr	31,34	zinc	Opr	MESH:D015032	65100(Tax:10090)	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A new murine zinc finger gene , Opr .
18971456	0	zinc	20,24	P2X2	42,46	zinc	P2X2	MESH:D015032	114115(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|receptors receptors|compound|END_ENTITY	Opposite effects of zinc on human and rat P2X2 receptors .
23112811	0	zinc	114,118	P2X2	36,40	zinc	P2X2	MESH:D015032	114115(Tax:10116)	Chemical	Gene	allows|nmod|START_ENTITY allows|nsubj|modification modification|nmod|receptors receptors|compound|END_ENTITY	Covalent modification of mutant rat P2X2 receptors with a thiol-reactive fluorophore allows channel activation by zinc or acidic pH without ATP .
18057239	4	zinc	551,555	PARP-1	599,605	zinc	PARP-1	MESH:D015032	25591(Tax:10116)	Chemical	Gene	trigger|nsubj|START_ENTITY trigger|dep|_ _|dobj|activation activation|appos|END_ENTITY	Excess zinc can trigger poly -LRB- ADP-ribose -RRB- _ polymerase_1 -LRB- PARP-1 -RRB- activation , and PARP-1 activation can mediate neuronal_death .
21233213	0	zinc	61,65	PARP-1	142,148	zinc	PARP-1	MESH:D015032	142	Chemical	Gene	fingers|compound|START_ENTITY structures|nmod|fingers structures|dep|insights insights|nmod|activity activity|compound|END_ENTITY	Crystal structures of poly -LRB- ADP-ribose -RRB- _ polymerase-1 -LRB- PARP-1 -RRB- zinc fingers bound to DNA : structural and functional insights into DNA-dependent PARP-1 activity .
21233213	0	zinc	61,65	PARP-1	53,59	zinc	PARP-1	MESH:D015032	142	Chemical	Gene	fingers|compound|START_ENTITY fingers|amod|polymerase-1 polymerase-1|dep|END_ENTITY	Crystal structures of poly -LRB- ADP-ribose -RRB- _ polymerase-1 -LRB- PARP-1 -RRB- zinc fingers bound to DNA : structural and functional insights into DNA-dependent PARP-1 activity .
21550982	7	zinc	1176,1180	PARP-1	1169,1175	zinc	PARP-1	MESH:D015032	142	Chemical	Gene	function|compound|START_ENTITY function|compound|END_ENTITY	To investigate the impact of arsenite on PARP-1 zinc finger function , we measured the zinc content and DNA-binding capacity of PARP-1 immunoprecipitated from arsenite-exposed cells .
21550982	7	zinc	1214,1218	PARP-1	1169,1175	zinc	PARP-1	MESH:D015032	142	Chemical	Gene	content|compound|START_ENTITY measured|dobj|content measured|advcl|investigate investigate|nmod|function function|compound|END_ENTITY	To investigate the impact of arsenite on PARP-1 zinc finger function , we measured the zinc content and DNA-binding capacity of PARP-1 immunoprecipitated from arsenite-exposed cells .
24275069	0	zinc	25,29	PARP-1	40,46	zinc	PARP-1	MESH:D015032	142	Chemical	Gene	loss|compound|START_ENTITY loss|nmod|END_ENTITY	Arsenite binding-induced zinc loss from PARP-1 is equivalent to zinc_deficiency in reducing PARP-1 activity , leading to inhibition of DNA repair .
24275069	0	zinc	25,29	PARP-1	92,98	zinc	PARP-1	MESH:D015032	142	Chemical	Gene	loss|compound|START_ENTITY equivalent|nsubj|loss equivalent|xcomp|zinc_deficiency zinc_deficiency|advcl|reducing reducing|dobj|activity activity|compound|END_ENTITY	Arsenite binding-induced zinc loss from PARP-1 is equivalent to zinc_deficiency in reducing PARP-1 activity , leading to inhibition of DNA repair .
22616817	0	zinc	30,34	PAT-9	11,16	zinc	PAT-9	MESH:D015032	181714(Tax:6239)	Chemical	Gene	protein|compound|START_ENTITY protein|nsubj|END_ENTITY	C. _ elegans PAT-9 is a nuclear zinc finger protein critical for the assembly of muscle attachments .
22493480	0	zinc	20,24	PATZ	52,56	zinc	PATZ	MESH:D015032	23598	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	POZ - , AT-hook - , and zinc finger-containing protein -LRB- PATZ -RRB- interacts with human oncogene B_cell_lymphoma_6 -LRB- BCL6 -RRB- and is required for its negative autoregulation .
21712612	0	zinc	21,25	PEPT1	105,110	zinc	PEPT1	MESH:D015032	117261(Tax:10116)	Chemical	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Inhibitory effect of zinc on the absorption of JBP485 via the gastrointestinal oligopeptide transporter -LRB- PEPT1 -RRB- in rats .
17215364	0	zinc	25,29	PEX10	61,66	zinc	PEX10	MESH:D015032	817175(Tax:3702)	Chemical	Gene	finger|compound|START_ENTITY finger|nmod|END_ENTITY	Requirement of the C3HC4 zinc RING finger of the Arabidopsis PEX10 for photorespiration and leaf peroxisome contact with chloroplasts .
10497277	0	zinc	27,31	PLZF	40,44	zinc	PLZF	MESH:D015032	7704	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	The promyelocytic_leukemia zinc finger -LRB- PLZF -RRB- protein binds DNA in a high molecular weight complex associated with cdc2 kinase .
12970399	0	zinc	24,28	PLZF	45,49	zinc	PLZF	MESH:D015032	7704	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Promyelocytic_leukaemia zinc finger protein -LRB- PLZF -RRB- is a glucocorticoid - and progesterone-induced transcription factor in human endometrial stromal cells and myometrial smooth muscle cells .
16547399	0	zinc	84,88	PLZF	97,101	zinc	PLZF	MESH:D015032	7704	Chemical	Gene	finger|compound|START_ENTITY finger|appos|END_ENTITY	Current topics in pharmacological research on bone metabolism : Promyelotic leukemia zinc finger -LRB- PLZF -RRB- and tumor_necrosis_factor-alpha-stimulated_gene_6 -LRB- TSG-6 -RRB- identified by gene expression analysis play roles in the pathogenesis of ossification_of_the_posterior_longitudinal_ligament .
17340613	0	zinc	66,70	PLZF	88,92	zinc	PLZF	MESH:D015032	7704	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	TIMP-1 regulates cell proliferation by interacting with the ninth zinc finger domain of PLZF .
18611983	0	zinc	58,62	PLZF	71,75	zinc	PLZF	MESH:D015032	7704	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Biallelic loss of function of the promyelocytic_leukaemia zinc finger -LRB- PLZF -RRB- gene causes severe skeletal_defects and genital_hypoplasia .
1569931	0	zinc	21,25	PRDI-BF1	78,86	zinc	PRDI-BF1	MESH:D015032	639	Chemical	Gene	fingers|compound|START_ENTITY fingers|nmod|END_ENTITY	Only two of the five zinc fingers of the eukaryotic transcriptional repressor PRDI-BF1 are required for sequence-specific DNA binding .
26840484	0	zinc	19,23	PRDM9	35,40	zinc	PRDM9	MESH:D015032	213389(Tax:10090)	Chemical	Gene	fingers|compound|START_ENTITY fingers|nmod|END_ENTITY	Re-engineering the zinc fingers of PRDM9 reverses hybrid sterility in mice .
20100827	0	zinc	121,125	PTEN	60,64	zinc	PTEN	MESH:D015032	5728	Chemical	Gene	ligase|nmod|START_ENTITY ligase|nsubj|interaction interaction|nmod|phosphatase_and_tensin_homologue phosphatase_and_tensin_homologue|appos|END_ENTITY	Functional interaction of phosphatase_and_tensin_homologue -LRB- PTEN -RRB- with the E3 ligase NEDD4-1 during neuronal response to zinc .
24024362	0	zinc	33,37	PTEN	88,92	zinc	PTEN	MESH:D015032	5728	Chemical	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	-LSB- Inhibitory effects of exogenous zinc on enzymatic activity of tumor suppressor protein PTEN and possible mechanisms in human airway epithelial cells -RSB- .
15226458	0	zinc	68,72	Peroxisome_proliferator_activated_receptors_alpha	0,49	zinc	Peroxisome proliferator activated receptors alpha	MESH:D015032	5465	Chemical	Gene	require|dobj|START_ENTITY require|nsubj|END_ENTITY	Peroxisome_proliferator_activated_receptors_alpha and gamma require zinc for their anti-inflammatory properties in porcine vascular endothelial cells .
9130664	0	zinc	33,37	Png-1	0,5	zinc	Png-1	MESH:D015032	55768	Chemical	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	Png-1 , a nervous system-specific zinc finger gene , identifies regions containing postmitotic neurons during mammalian embryonic development .
18498651	0	zinc	53,57	Pr55Gag	45,52	zinc	Pr55Gag	MESH:D015032	155030(Tax:11676)	Chemical	Gene	fingers|compound|START_ENTITY fingers|amod|END_ENTITY	The host protein Staufen1 interacts with the Pr55Gag zinc fingers and regulates HIV-1 assembly via its N-terminus .
9018332	0	zinc	55,59	Prolactin	0,9	zinc	Prolactin	MESH:D015032	24683(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	Prolactin and testosterone regulation of mitochondrial zinc in prostate epithelial cells .
9037026	0	zinc	9,13	REST	51,55	zinc	REST	MESH:D015032	5978	Chemical	Gene	motif|compound|START_ENTITY motif|nmod|END_ENTITY	A single zinc finger motif in the silencing factor REST represses the neural-specific type II sodium channel promoter .
1923755	0	zinc	68,72	RGM1	45,49	zinc	RGM1	MESH:D015032	855220(Tax:4932)	Chemical	Gene	protein|compound|START_ENTITY protein|nsubj|END_ENTITY	The yeast putative transcriptional repressor RGM1 is a proline-rich zinc finger protein .
10075714	0	zinc	16,20	RIN_ZF	0,6	zinc	RIN ZF	MESH:D015032	80338(Tax:10116)	Chemical	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	RIN_ZF , a novel zinc finger gene , encodes proteins that bind to the CACC element of the gastrin promoter .
17693662	0	zinc	40,44	RIZ	57,60	zinc	RIZ	MESH:D015032	7799	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genetic polymorphisms in the Rb-binding zinc finger gene RIZ and the risk of lung_cancer .
8972184	0	zinc	14,18	Raf	10,13	zinc	Raf	MESH:D015032	22882	Chemical	Gene	finger|compound|START_ENTITY finger|amod|END_ENTITY	An intact Raf zinc finger is required for optimal binding to processed Ras and for ras-dependent Raf activation in situ .
9242688	0	zinc	76,80	Raf	72,75	zinc	Raf	MESH:D015032	22882	Chemical	Gene	finger|compound|START_ENTITY finger|compound|END_ENTITY	Activity of plasma membrane-recruited Raf-1 is regulated by Ras via the Raf zinc finger .
10601307	0	zinc	4,8	RanBP2	34,40	zinc	RanBP2	MESH:D015032	5903	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor , exportin-1 .
25044781	0	zinc	44,48	RanBP2	37,43	zinc	RanBP2	MESH:D015032	5903	Chemical	Gene	finger|compound|START_ENTITY finger|amod|END_ENTITY	Engineering specificity changes on a RanBP2 zinc finger that binds single-stranded RNA .
17239974	0	zinc	16,20	S100A2	32,38	zinc	S100A2	MESH:D015032	6273	Chemical	Gene	Implications|nmod|START_ENTITY Implications|amod|binding binding|nmod|END_ENTITY	Implications on zinc binding to S100A2 .
19028685	0	zinc	100,104	SAF-1	123,128	zinc	SAF-1	MESH:D015032	4150	Chemical	Gene	domains|compound|START_ENTITY domains|nmod|END_ENTITY	Transcriptional synergy mediated by SAF-1 and AP-1 : critical role of N-terminal polyalanine and two zinc finger domains of SAF-1 .
16402211	0	zinc	8,12	SALL4	2,7	zinc	SALL4	MESH:D015032	57167	Chemical	Gene	mutation|compound|START_ENTITY mutation|compound|END_ENTITY	A SALL4 zinc finger missense mutation predicted to result in increased DNA binding affinity is associated with cranial_midline_defects and mild features of Okihiro_syndrome .
10400677	0	zinc	14,18	SIP1	0,4	zinc	SIP1	MESH:D015032	100049718(Tax:8355)	Chemical	Gene	repressor|compound|START_ENTITY END_ENTITY|appos|repressor	SIP1 , a novel zinc finger/homeodomain repressor , interacts with Smad proteins and binds to 5 ' - CACCT sequences in candidate target genes .
17554684	0	zinc	15,19	SIP1	45,49	zinc	SIP1	MESH:D015032	100049718(Tax:8355)	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	The N-terminus zinc finger domain of Xenopus SIP1 is important for neural induction , but not for suppression of Xbra expression .
17065149	0	zinc	71,75	SLC30A2	32,39	zinc	SLC30A2	MESH:D015032	7780	Chemical	Gene	women|nmod|START_ENTITY ZnT-2|nmod|women ZnT-2|compound|END_ENTITY	Identification of a mutation in SLC30A2 -LRB- ZnT-2 -RRB- in women with low milk zinc concentration that results in transient neonatal_zinc_deficiency .
17349999	0	zinc	123,127	SLC30A2	20,27	zinc	SLC30A2	MESH:D015032	7780	Chemical	Gene	accumulation|compound|START_ENTITY promoting|dobj|accumulation suppress|advcl|promoting suppress|nsubj|transporter transporter|appos|END_ENTITY	Zinc transporter 2 -LRB- SLC30A2 -RRB- can suppress the vesicular zinc defect of adaptor_protein_3-depleted fibroblasts by promoting zinc accumulation in lysosomes .
17349999	0	zinc	56,60	SLC30A2	20,27	zinc	SLC30A2	MESH:D015032	7780	Chemical	Gene	defect|compound|START_ENTITY suppress|dobj|defect suppress|nsubj|transporter transporter|appos|END_ENTITY	Zinc transporter 2 -LRB- SLC30A2 -RRB- can suppress the vesicular zinc defect of adaptor_protein_3-depleted fibroblasts by promoting zinc accumulation in lysosomes .
22364884	0	zinc	81,85	SLC30A2	17,24	zinc	SLC30A2	MESH:D015032	7780	Chemical	Gene	associated|nmod|START_ENTITY associated|nsubj|Polymorphisms Polymorphisms|nmod|factors factors|compound|END_ENTITY	Polymorphisms of SLC30A2 and selected perinatal factors associated with low milk zinc in Chinese breastfeeding women .
22733820	0	zinc	54,58	SLC30A2	79,86	zinc	SLC30A2	MESH:D015032	7780	Chemical	Gene	transporter|compound|START_ENTITY mutation|nmod|transporter mutation|appos|ZnT-2 ZnT-2|appos|END_ENTITY	A dominant negative heterozygous G87R mutation in the zinc transporter , ZnT-2 -LRB- SLC30A2 -RRB- , results in transient_neonatal_zinc_deficiency .
23849395	0	zinc	24,28	SLC30A3	49,56	zinc	SLC30A3	MESH:D015032	7781	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Allelic variants in the zinc transporter-3 gene , SLC30A3 , a candidate gene identified from gene expression studies , show gender-specific association with schizophrenia .
25249019	0	zinc	75,79	SLC30A3	0,7	zinc	SLC30A3	MESH:D015032	7781	Chemical	Gene	concentrations|nmod|START_ENTITY influence|dobj|concentrations influence|nsubj|polymorphisms polymorphisms|compound|END_ENTITY	SLC30A3 and SEP15 gene polymorphisms influence the serum concentrations of zinc and selenium in mature adults .
17234632	0	zinc	29,33	SLC30A5	52,59	zinc	SLC30A5	MESH:D015032	64924	Chemical	Gene	ZnT5|compound|START_ENTITY ZnT5|appos|END_ENTITY	Splice variants of the human zinc transporter ZnT5 -LRB- SLC30A5 -RRB- are differentially localized and regulated by zinc through transcription and mRNA stability .
19245740	0	zinc	114,118	SLC30A5	33,40	zinc	SLC30A5	MESH:D015032	64924	Chemical	Gene	status|compound|START_ENTITY decline|nmod|status contribute|nmod|decline zinc|acl:relcl|contribute zinc|compound|END_ENTITY	Does promoter methylation of the SLC30A5 -LRB- ZnT5 -RRB- zinc transporter gene contribute to the ageing-related decline in zinc status ?
26319140	0	zinc	112,116	SLC30A5	45,52	zinc	SLC30A5	MESH:D015032	64924	Chemical	Gene	secretion|compound|START_ENTITY disorder|nmod|secretion underlies|dobj|disorder underlies|nsubj|expression expression|nmod|transporters transporters|appos|END_ENTITY	Altered expression of two zinc transporters , SLC30A5 and SLC30A6 , underlies a mammary gland disorder of reduced zinc secretion into milk .
26319140	0	zinc	26,30	SLC30A5	45,52	zinc	SLC30A5	MESH:D015032	64924	Chemical	Gene	transporters|compound|START_ENTITY transporters|appos|END_ENTITY	Altered expression of two zinc transporters , SLC30A5 and SLC30A6 , underlies a mammary gland disorder of reduced zinc secretion into milk .
20525392	0	zinc	50,54	SLC30A8	134,141	zinc	SLC30A8	MESH:D015032	169026	Chemical	Gene	transporter|compound|START_ENTITY structure|nmod|transporter predicted|nsubj|structure predicted|nmod|R325W R325W|compound|END_ENTITY	Three-dimensional structure of beta-cell-specific zinc transporter , ZnT-8 , predicted from the type 2 diabetes-associated gene variant SLC30A8 R325W .
21810599	0	zinc	6,10	SLC30A8	79,86	zinc	SLC30A8	MESH:D015032	169026	Chemical	Gene	intake|compound|START_ENTITY modify|nsubj|intake modify|dobj|effect effect|nmod|variant variant|appos|END_ENTITY	Total zinc intake may modify the glucose-raising effect of a zinc transporter -LRB- SLC30A8 -RRB- variant : a 14-cohort meta-analysis .
21810599	0	zinc	61,65	SLC30A8	79,86	zinc	SLC30A8	MESH:D015032	169026	Chemical	Gene	variant|compound|START_ENTITY variant|appos|END_ENTITY	Total zinc intake may modify the glucose-raising effect of a zinc transporter -LRB- SLC30A8 -RRB- variant : a 14-cohort meta-analysis .
16819703	0	zinc	65,69	SLC39A4	87,94	zinc	SLC39A4	MESH:D015032	55630	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Acrodermatitis_enteropathica -LRB- AE -RRB- is caused by mutations in the zinc transporter gene SLC39A4 -RSB- .
10518215	0	zinc	22,26	SLUG	0,4	zinc	SLUG	MESH:D015032	6591	Chemical	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	SLUG , a ces-1-related zinc finger transcription factor gene with antiapoptotic activity , is a downstream target of the E2A-HLF oncoprotein .
19671315	0	zinc	71,75	SNAI1	104,109	zinc	SNAI1	MESH:D015032	6615	Chemical	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Hepatitis_B_virus X protein upregulates the transcription activity of zinc finger transcription factor SNAI1 -RSB- .
16901896	0	zinc	22,26	SNAP50	15,21	zinc	SNAP50	MESH:D015032	6619	Chemical	Gene	domain|compound|START_ENTITY domain|nummod|END_ENTITY	The unorthodox SNAP50 zinc finger domain contributes to cooperative promoter recognition by human SNAPC .
1998516	0	zinc	36,40	SP1	32,35	zinc	SP1	MESH:D015032	6667	Chemical	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	Amino_acid substitutions in the SP1 zinc finger domain alter the DNA binding affinity to cognate SP1 target site .
1998516	0	zinc	36,40	SP1	97,100	zinc	SP1	MESH:D015032	6667	Chemical	Gene	domain|compound|START_ENTITY substitutions|nmod|domain alter|nsubj|substitutions alter|dobj|DNA DNA|amod|binding binding|xcomp|cognate cognate|dobj|site site|nummod|END_ENTITY	Amino_acid substitutions in the SP1 zinc finger domain alter the DNA binding affinity to cognate SP1 target site .
2025269	0	zinc	59,63	SP1	55,58	zinc	SP1	MESH:D015032	6667	Chemical	Gene	domains|compound|START_ENTITY domains|nummod|END_ENTITY	Transition metals modulate DNA-protein interactions of SP1 zinc finger domains with its cognate target site .
8736557	0	zinc	36,40	SWI5	58,62	zinc	SWI5	MESH:D015032	851724(Tax:4932)	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	The solution structure of the first zinc finger domain of SWI5 : a novel structural extension to a common fold .
25899393	0	zinc	41,45	Sip1	19,23	zinc	Sip1	MESH:D015032	84404(Tax:10116)	Chemical	Gene	metalloprotease|compound|START_ENTITY END_ENTITY|dep|metalloprotease	Edwardsiella_tarda Sip1 : A serum-induced zinc metalloprotease that is essential to serum resistance and host_infection .
12743795	0	zinc	12,16	Slc30A4	38,45	zinc	Slc30A4	MESH:D015032	7782	Chemical	Gene	transporter|compound|START_ENTITY Analysis|nmod|transporter Analysis|appos|END_ENTITY	Analysis of zinc transporter , hZnT4 -LRB- Slc30A4 -RRB- , gene expression in a mammary_gland_disorder leading to reduced zinc secretion into milk .
23404848	6	zinc	849,853	Slc30a2	922,929	zinc	Slc39a7	MESH:D015032	14977(Tax:10090)	Chemical	Gene	Slc30a5|compound|START_ENTITY Slc30a5|dep|END_ENTITY	The mRNA transcripts for the zinc transporter proteins Slc39a6 , Slc39a8 , Slc39a9 , Slc39a10 , Slc39a12 , Slc30a2 , Slc30a4 , Slc30a5 and Slc30a8 mRNAs were higher in oocytes , while Slc39a1 , Slc39a7 , Slc39a13 , Slc39a14 , Slc30a6 , Slc30a7 and Slc30a9 mRNAs were higher in cumulus cells .
19450229	0	zinc	44,48	Slc30a8	22,29	zinc	Slc30a8	MESH:D015032	239436(Tax:10090)	Chemical	Gene	results|compound|START_ENTITY results|compound|END_ENTITY	Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired_insulin_secretion .
19458277	0	zinc	28,32	Slc39a3	6,13	zinc	Slc39a3	MESH:D015032	106947(Tax:10090)	Chemical	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	Zip3 -LRB- Slc39a3 -RRB- functions in zinc reuptake from the alveolar lumen in lactating mammary gland .
18020946	0	zinc	120,124	Slc39a5	112,119	zinc	Slc39a5	MESH:D015032	72002(Tax:10090)	Chemical	Gene	transporters|compound|START_ENTITY transporters|amod|END_ENTITY	Novel zinc-responsive post-transcriptional mechanisms reciprocally regulate expression of the mouse Slc39a4 and Slc39a5 zinc transporters -LRB- Zip4 and Zip5 -RRB- .
24303081	0	zinc	4,8	Slc39a5	27,34	zinc	Slc39a5	MESH:D015032	72002(Tax:10090)	Chemical	Gene	Zip5|compound|START_ENTITY Zip5|appos|END_ENTITY	The zinc transporter Zip5 -LRB- Slc39a5 -RRB- regulates intestinal zinc excretion and protects the pancreas against zinc_toxicity .
24303081	0	zinc	57,61	Slc39a5	27,34	zinc	Slc39a5	MESH:D015032	72002(Tax:10090)	Chemical	Gene	excretion|compound|START_ENTITY regulates|dobj|excretion regulates|nsubj|Zip5 Zip5|appos|END_ENTITY	The zinc transporter Zip5 -LRB- Slc39a5 -RRB- regulates intestinal zinc excretion and protects the pancreas against zinc_toxicity .
15705588	0	zinc	34,38	Slc39a7	15,22	zinc	Slc39a7	MESH:D015032	7922	Chemical	Gene	transporter|compound|START_ENTITY encodes|dobj|transporter encodes|nsubj|gene gene|appos|END_ENTITY	The ZIP7 gene -LRB- Slc39a7 -RRB- encodes a zinc transporter involved in zinc homeostasis of the Golgi apparatus .
15705588	0	zinc	63,67	Slc39a7	15,22	zinc	Slc39a7	MESH:D015032	7922	Chemical	Gene	homeostasis|compound|START_ENTITY involved|nmod|homeostasis transporter|acl|involved encodes|dobj|transporter encodes|nsubj|gene gene|appos|END_ENTITY	The ZIP7 gene -LRB- Slc39a7 -RRB- encodes a zinc transporter involved in zinc homeostasis of the Golgi apparatus .
24265765	0	zinc	4,8	Slc39a7	22,29	zinc	Slc39a7	MESH:D015032	7922	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	The zinc transporter , Slc39a7 -LRB- Zip7 -RRB- is implicated in glycaemic control in skeletal muscle cells .
12398892	0	zinc	25,29	Slug	0,4	zinc	Slug	MESH:D015032	20583(Tax:10090)	Chemical	Gene	repressor|compound|START_ENTITY END_ENTITY|appos|repressor	Slug , a highly conserved zinc finger transcriptional repressor , protects hematopoietic progenitor cells from radiation-induced apoptosis in vivo .
7513443	0	zinc	66,70	Slug	58,62	zinc	Slug	MESH:D015032	432368(Tax:9031)	Chemical	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	Control of cell behavior during vertebrate development by Slug , a zinc finger gene .
9165129	0	zinc	8,12	Slug	0,4	zinc	Slug	MESH:D015032	432368(Tax:9031)	Chemical	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	Slug , a zinc finger gene previously implicated in the early patterning of the mesoderm and the neural crest , is also involved in chick limb development .
18372076	0	zinc	28,32	Snail	13,18	zinc	Snail	MESH:D015032	6615	Chemical	Gene	factor|compound|START_ENTITY END_ENTITY|appos|factor	Knockdown of Snail , a novel zinc finger transcription factor , via RNA interference increases A549 cell sensitivity to cisplatin via JNK/mitochondrial pathway .
10415854	0	zinc	82,86	Sp1	0,3	zinc	Sp1	MESH:D015032	6667	Chemical	Gene	factors|compound|START_ENTITY family|nmod|factors predictions|nmod|family END_ENTITY|dep|predictions	Sp1 and its likes : biochemical and functional predictions for a growing family of zinc finger transcription factors .
11327841	0	zinc	34,38	Sp1	54,57	zinc	Sp1	MESH:D015032	6667	Chemical	Gene	finger|compound|START_ENTITY change|nmod|finger END_ENTITY|dep|change	Finger-positional change in three zinc finger protein Sp1 : influence of terminal finger in DNA recognition .
11395515	0	zinc	16,20	Sp1	32,35	zinc	Sp1	MESH:D015032	6667	Chemical	Gene	fingers|compound|START_ENTITY fingers|nmod|END_ENTITY	Two consecutive zinc fingers in Sp1 and in MAZ are essential for interactions with cis-elements .
12049774	0	zinc	37,41	Sp1	25,28	zinc	Sp1	MESH:D015032	431939(Tax:8355)	Chemical	Gene	finger|compound|START_ENTITY finger|amod|END_ENTITY	XSPR-1 and XSPR-2 , novel Sp1 related zinc finger containing genes , are dynamically expressed during Xenopus embryogenesis .
12102624	0	zinc	86,90	Sp1	101,104	zinc	Sp1	MESH:D015032	6667	Chemical	Gene	finger|compound|START_ENTITY finger|nmod|END_ENTITY	Interconversion between serine and aspartic_acid in the alpha helix of the N-terminal zinc finger of Sp1 : implication for general recognition code and for design of novel zinc finger peptide recognizing complementary strand .
12565691	0	zinc	89,93	Sp1	56,59	zinc	Sp1	MESH:D015032	6667	Chemical	Gene	supplementation|compound|START_ENTITY prevented|nmod|supplementation prevented|nsubjpass|perturbations perturbations|nmod|DNA-binding DNA-binding|amod|END_ENTITY	Lead-induced developmental perturbations in hippocampal Sp1 DNA-binding are prevented by zinc supplementation : in vivo evidence for Pb and Zn competition .
1289808	0	zinc	61,65	Sp1	57,60	zinc	Sp1	MESH:D015032	6667	Chemical	Gene	finger|compound|START_ENTITY finger|amod|END_ENTITY	Recognition and structural perturbation of GC box DNA by Sp1 zinc finger .
15147220	0	zinc	50,54	Sp1	38,41	zinc	Sp1	MESH:D015032	6667	Chemical	Gene	fingers|compound|START_ENTITY fingers|compound|END_ENTITY	Exchange of histidine spacing between Sp1 and GLI zinc fingers : distinct effect of histidine spacing-linker region on DNA binding .
15362956	0	zinc	93,97	Sp1	89,92	zinc	Sp1	MESH:D015032	6667	Chemical	Gene	proteins|compound|START_ENTITY proteins|amod|END_ENTITY	Transcriptional regulation of the human DNA_methyltransferase_3A and 3B genes by Sp3 and Sp1 zinc finger proteins .
15709764	0	zinc	153,157	Sp1	44,47	zinc	Sp1	MESH:D015032	6667	Chemical	Gene	peptides|compound|START_ENTITY properties|nmod|peptides region|nmod|properties role|nmod|region Swapping|dep|role Swapping|nmod|region region|nmod|fingers fingers|compound|END_ENTITY	Swapping of the beta-hairpin region between Sp1 and GLI zinc fingers : significant role of the beta-hairpin region in DNA binding properties of C2H2-type zinc finger peptides .
15709764	0	zinc	56,60	Sp1	44,47	zinc	Sp1	MESH:D015032	6667	Chemical	Gene	fingers|compound|START_ENTITY fingers|compound|END_ENTITY	Swapping of the beta-hairpin region between Sp1 and GLI zinc fingers : significant role of the beta-hairpin region in DNA binding properties of C2H2-type zinc finger peptides .
15878880	0	zinc	83,87	Sp1	28,31	zinc	Sp1	MESH:D015032	6667	Chemical	Gene	domain|compound|START_ENTITY interactions|nmod|domain regulated|nmod|interactions regulated|nsubjpass|activity activity|nmod|END_ENTITY	Transcriptional activity of Sp1 is regulated by molecular interactions between the zinc finger DNA binding domain and the inhibitory domain with corepressors , and this interaction is modulated by MEK .
18258854	0	zinc	121,125	Sp1	143,146	zinc	Sp1	MESH:D015032	6667	Chemical	Gene	region|compound|START_ENTITY region|nmod|END_ENTITY	Angiotensin_II-inducible platelet-derived_growth_factor-D transcription requires specific Ser/Thr residues in the second zinc finger region of Sp1 .
19138671	0	zinc	8,12	Sp1	78,81	zinc	Sp1	MESH:D015032	6667	Chemical	Gene	structure|compound|START_ENTITY Role|nmod|structure Role|nmod|END_ENTITY	Role of zinc finger structure in nuclear localization of transcription factor Sp1 .
2001744	0	zinc	87,91	Sp1	117,120	zinc	Sp1	MESH:D015032	6667	Chemical	Gene	finger|compound|START_ENTITY finger|acl|containing containing|dobj|END_ENTITY	Thionein -LRB- apometallothionein -RRB- can modulate DNA binding and transcription activation by zinc finger containing factor Sp1 .
20060848	0	zinc	125,129	Sp1	147,150	zinc	Sp1	MESH:D015032	20683(Tax:10090)	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Cadmium down-regulation of kidney Sp1 binding to mouse SGLT1 and SGLT2 gene promoters : possible reaction of cadmium with the zinc finger domain of Sp1 .
20060848	0	zinc	125,129	Sp1	34,37	zinc	Sp1	MESH:D015032	20683(Tax:10090)	Chemical	Gene	domain|compound|START_ENTITY cadmium|nmod|domain reaction|nmod|cadmium down-regulation|dep|reaction down-regulation|nmod|END_ENTITY	Cadmium down-regulation of kidney Sp1 binding to mouse SGLT1 and SGLT2 gene promoters : possible reaction of cadmium with the zinc finger domain of Sp1 .
2011120	0	zinc	43,47	Sp1	101,104	zinc	Sp1	MESH:D015032	6667	Chemical	Gene	domain|compound|START_ENTITY Generation|nmod|domain Generation|nmod|END_ENTITY	Generation of monoclonal antibodies to the zinc finger domain of the eukaryotic transcription factor Sp1 .
20229304	0	zinc	49,53	Sp1	37,40	zinc	Sp1	MESH:D015032	6667	Chemical	Gene	domain|compound|START_ENTITY domain|amod|END_ENTITY	Synthesis and DNA-binding ability of Sp1 protein zinc finger domain and its peptidomimetics .
21396899	0	zinc	40,44	Sp1	94,97	zinc	Sp1	MESH:D015032	6667	Chemical	Gene	proteins|compound|START_ENTITY assay|nmod|proteins assay|dep|competition competition|nmod|Zn Zn|acl|bound bound|nmod|END_ENTITY	Electrophoretic mobility shift assay of zinc finger proteins : competition for Zn -LRB- 2 + -RRB- bound to Sp1 in protocols including EDTA .
26316464	0	zinc	62,66	Sp1	162,165	zinc	Sp1	MESH:D015032	6667	Chemical	Gene	nuclease|compound|START_ENTITY nuclease|acl|containing containing|dobj|domain domain|acl|derived derived|nmod|domain domain|nmod|END_ENTITY	Efficient cleavage of DNA oligonucleotides by a non-FokI-type zinc finger nuclease containing one His4-type finger domain derived from the first finger domain of Sp1 .
3135532	0	zinc	110,114	Sp1	59,62	zinc	Sp1	MESH:D015032	6667	Chemical	Gene	requires|dobj|START_ENTITY requires|nsubj|ions ions|nmod|factors factors|dep|END_ENTITY	Heavy metal ions in transcription factors from HeLa cells : Sp1 , but not octamer transcription factor requires zinc for DNA binding and for activator function .
7685185	0	zinc	112,116	Sp1	32,35	zinc	Sp1	MESH:D015032	6667	Chemical	Gene	fingers|compound|START_ENTITY contact|nmod|fingers Binding|dep|contact Binding|nmod|END_ENTITY	Binding of transcription factor Sp1 to GC box DNA revealed by footprinting analysis : different contact of three zinc fingers and sequence recognition mode .
8352809	0	zinc	75,79	Sp1	117,120	zinc	Sp1	MESH:D015032	6667	Chemical	Gene	substitution|nmod|START_ENTITY substitution|dobj|fingers fingers|nmod|END_ENTITY	Alteration of DNA binding specificity by nickel -LRB- II -RRB- substitution in three zinc -LRB- II -RRB- fingers of transcription factor Sp1 .
8605284	0	zinc	22,26	Sp1	18,21	zinc	Sp1	MESH:D015032	6667	Chemical	Gene	finger|compound|START_ENTITY finger|amod|END_ENTITY	Properties of the Sp1 zinc finger 3 peptide : coordination chemistry , redox reactions , and metal binding competition with metallothionein .
9065444	0	zinc	14,18	Sp1	60,63	zinc	Sp1	MESH:D015032	6667	Chemical	Gene	finger|compound|START_ENTITY Structures|nmod|finger domains|nsubj|Structures domains|nmod|END_ENTITY	Structures of zinc finger domains from transcription factor Sp1 .
9578568	0	zinc	42,46	Sp1	78,81	zinc	Sp1	MESH:D015032	6667	Chemical	Gene	finger|compound|START_ENTITY finger|nmod|END_ENTITY	Unique DNA binding mode of the N-terminal zinc finger of transcription factor Sp1 .
9586044	0	zinc	33,37	Sp1	70,73	zinc	Sp1	MESH:D015032	6667	Chemical	Gene	fingers|compound|START_ENTITY fingers|nmod|END_ENTITY	Different contributions of three zinc fingers of transcription factor Sp1 to DNA recognition : novel binding mode of N-terminal finger_1 .
12071960	0	zinc	61,65	Sp3	57,60	zinc	Sp3	MESH:D015032	20687(Tax:10090)	Chemical	Gene	proteins|compound|START_ENTITY proteins|amod|END_ENTITY	Regulation of transcription of the Dnmt1 gene by Sp1 and Sp3 zinc finger proteins .
10455183	0	zinc	131,135	Staf	126,130	zinc	Staf	MESH:D015032	7702	Chemical	Gene	finger|compound|START_ENTITY finger|compound|END_ENTITY	Maximization of selenocysteine tRNA and U6 small nuclear RNA transcriptional activation achieved by flexible utilization of a Staf zinc finger .
23070743	6	zinc	1100,1104	TAS2R107	1057,1065	zinc	TAS2R121	MESH:D015032	78983(Tax:10116)	Chemical	Gene	administration|compound|START_ENTITY administration|compound|END_ENTITY	RESULTS : Gene expression frequency of TAS2R40 and TAS2R107 significantly decreased in rats fed a zinc-deficient diet , and frequency of TAS2R107 significantly increased following zinc administration .
10733531	0	zinc	4,8	TFIIB	61,66	zinc	TFIIB	MESH:D015032	2959	Chemical	Gene	domains|compound|START_ENTITY domains|nmod|END_ENTITY	The zinc ribbon domains of the general transcription factors TFIIB and Brf : conserved functional surfaces but different roles in transcription initiation .
14536083	0	zinc	78,82	TFIIB	72,77	zinc	TFIIB	MESH:D015032	2959	Chemical	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	Binding of TFIIB to RNA polymerase II : Mapping the binding site for the TFIIB zinc ribbon domain within the preinitiation_complex .
15024075	0	zinc	36,40	TFIIB	30,35	zinc	TFIIB	MESH:D015032	2959	Chemical	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	A nonconserved surface of the TFIIB zinc ribbon domain plays a direct role in RNA polymerase II recruitment .
16272138	0	zinc	95,99	TFIIEalpha	123,133	zinc	TFIIEalpha	MESH:D015032	2960	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Structural insights into the asymmetric effects of zinc-ligand cysteine mutations in the novel zinc ribbon domain of human TFIIEalpha for transcription .
11132629	0	zinc	10,14	TFIIIA	25,31	zinc	TFIIIA	MESH:D015032	397777(Tax:8355)	Chemical	Gene	finger|compound|START_ENTITY finger|nmod|END_ENTITY	The third zinc finger of TFIIIA stabilizes a hairpin structure of the non-coding strand in the internal control region of 5S RNA gene .
1538401	0	zinc	40,44	TFIIIA	56,62	zinc	TFIIIA	MESH:D015032	397777(Tax:8355)	Chemical	Gene	fingers|compound|START_ENTITY fingers|nmod|END_ENTITY	Specific interaction of the first three zinc fingers of TFIIIA with the internal control region of the Xenopus 5 S RNA gene .
1827669	0	zinc	20,24	TFIIIA	36,42	zinc	TFIIIA	MESH:D015032	397777(Tax:8355)	Chemical	Gene	fingers|compound|START_ENTITY fingers|nmod|END_ENTITY	The carboxyterminal zinc fingers of TFIIIA interact with the tip of helix V of 5S RNA in the 7S ribonucleoprotein particle .
8336715	0	zinc	15,19	TFIIIA	8,14	zinc	TFIIIA	MESH:D015032	397777(Tax:8355)	Chemical	Gene	fingers|compound|START_ENTITY fingers|compound|END_ENTITY	Role of TFIIIA zinc fingers in vivo : analysis of single-finger function in developing Xenopus embryos .
8346014	0	zinc	66,70	TFIIIA	82,88	zinc	TFIIIA	MESH:D015032	2971	Chemical	Gene	fingers|compound|START_ENTITY fingers|nmod|END_ENTITY	A role in DNA binding for the linker sequences of the first three zinc fingers of TFIIIA .
9367756	0	zinc	38,42	TFIIIA	54,60	zinc	TFIIIA	MESH:D015032	397777(Tax:8355)	Chemical	Gene	fingers|compound|START_ENTITY fingers|nmod|END_ENTITY	Solution structure of the first three zinc fingers of TFIIIA bound to the cognate DNA sequence : determinants of affinity and sequence specificity .
18073205	0	zinc	40,44	THAP1	55,60	zinc	THAP1	MESH:D015032	55145	Chemical	Gene	finger|compound|START_ENTITY finger|nmod|END_ENTITY	Structure-function analysis of the THAP zinc finger of THAP1 , a large C2CH DNA-binding module linked to Rb/E2F pathways .
10506214	0	zinc	107,111	TIEG	80,84	zinc	TIEG	MESH:D015032	7071	Chemical	Gene	proteins|compound|START_ENTITY feature|nmod|proteins feature|nmod|subfamily subfamily|compound|END_ENTITY	Three conserved transcriptional repressor domains are a defining feature of the TIEG subfamily of Sp1-like zinc finger proteins .
9153278	0	zinc	40,44	TIEG	67,71	zinc	TIEG	MESH:D015032	7071	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Overexpression of the TGFbeta-regulated zinc finger encoding gene , TIEG , induces apoptosis in pancreatic epithelial cells .
25808614	0	zinc	53,57	TNFa	0,4	zinc	TNFa	MESH:D015032	7124	Chemical	Gene	targets|nmod|START_ENTITY targets|nsubj|END_ENTITY	TNFa post-translationally targets ZnT2 to accumulate zinc in lysosomes .
18331824	0	zinc	54,58	TWIST	39,44	zinc	TWIST	MESH:D015032	7291	Chemical	Gene	factor|compound|START_ENTITY END_ENTITY|appos|factor	Short interfering RNA directed against TWIST , a novel zinc finger transcription factor , increases A549 cell sensitivity to cisplatin via MAPK/mitochondrial pathway .
26770438	0	zinc	40,44	TWIST	31,36	zinc	TWIST	MESH:D015032	7291	Chemical	Gene	factor|compound|START_ENTITY END_ENTITY|appos|factor	Expression and significance of TWIST , a zinc finger transcription factor , in laryngeal_carcinoma among Chinese population : a meta-analysis .
1585646	0	zinc	46,50	Tax	54,57	zinc	Tax	MESH:D015032	6900	Chemical	Gene	START_ENTITY|nmod|structure structure|compound|END_ENTITY	HTLV-I Tax is a zinc-binding protein : role of zinc in Tax structure and function .
10499817	1	zinc	55,59	Th1	50,53	zinc	Th1	MESH:D015032	51497	Chemical	Gene	protect|nsubj|START_ENTITY protect|nmod|END_ENTITY	Under Th1 , zinc and nitrogen_monoxide -LRB- NO -RRB- collectively protect against viruses , AIDS , autoimmunity , diabetes , allergies , asthma , infectious_diseases , atherosclerosis and cancer .
17963238	0	zinc	92,96	Tim10	16,21	zinc	Tim10	MESH:D015032	26519	Chemical	Gene	protein|compound|START_ENTITY intermediate|nmod|protein existence|nmod|intermediate evidence|nmod|existence binding|dep|evidence binding|nmod|END_ENTITY	Zinc binding of Tim10 : evidence for existence of an unstructured binding intermediate for a zinc finger protein .
16212555	0	zinc	66,70	TrZnT-1	91,98	zinc	TrZnT-1	MESH:D015032	503653(Tax:31033)	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Identification , cloning and characterization of a plasma membrane zinc efflux transporter , TrZnT-1 , from fugu pufferfish -LRB- Takifugu_rubripes -RRB- .
7647035	0	zinc	51,55	Transforming_growth_factor_alpha	0,32	zinc	Transforming growth factor alpha	MESH:D015032	24827(Tax:10116)	Chemical	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	Transforming_growth_factor_alpha regulation of two zinc finger-containing immediate early response genes in intestine .
20400505	0	zinc	20,24	Trm112p	0,7	zinc	Trm112p	MESH:D015032	855782(Tax:4932)	Chemical	Gene	protein|compound|START_ENTITY protein|nsubj|END_ENTITY	Trm112p is a 15-kDa zinc finger protein essential for the activity of two tRNA and one protein methyltransferases in yeast .
7722694	0	zinc	58,62	Tumor_necrosis_factor-alpha	0,27	zinc	Tumor necrosis factor-alpha	MESH:D015032	21926(Tax:10090)	Chemical	Gene	metabolism|compound|START_ENTITY alters|dobj|metabolism alters|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha alters maternal and embryonic zinc metabolism and is developmentally toxic in mice .
15881673	0	zinc	10,14	UBC9	78,82	zinc	UBC9	MESH:D015032	7329	Chemical	Gene	finger|compound|START_ENTITY interacts|nsubj|finger interacts|nmod|END_ENTITY	A Kruppel zinc finger of ZNF 146 interacts with the SUMO-1 conjugating enzyme UBC9 and is sumoylated in vivo .
8396146	0	zinc	19,23	Vitamin_D_receptor	0,18	zinc	Vitamin D receptor	MESH:D015032	7421	Chemical	Gene	region|compound|START_ENTITY region|compound|END_ENTITY	Vitamin_D_receptor zinc finger region binds to a direct repeat as a dimer and discriminates the spacing number between each half-site .
1840635	0	zinc	11,15	Vps18p	57,63	zinc	Vps18p	MESH:D015032	850840(Tax:4932)	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	A putative zinc finger protein , Saccharomyces_cerevisiae Vps18p , affects late Golgi functions required for vacuolar protein sorting and efficient alpha-factor prohormone maturation .
22209848	0	zinc	85,89	WRNIP1	0,6	zinc	WRNIP1	MESH:D015032	56897	Chemical	Gene	domain|compound|START_ENTITY irradiated|nmod|domain irradiated|nsubj|accumulates accumulates|nummod|END_ENTITY	WRNIP1 accumulates at laser light irradiated sites rapidly via its ubiquitin-binding zinc finger domain and independently from its ATPase domain .
27062441	0	zinc	63,67	WRNIP1	85,91	zinc	WRNIP1	MESH:D015032	56897	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	A novel mode of ubiquitin recognition by the ubiquitin-binding zinc finger domain of WRNIP1 .
15138600	0	zinc	22,26	Wig-1	16,21	zinc	Wig-1	MESH:D015032	64393	Chemical	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	The p53-induced Wig-1 zinc finger protein is highly conserved from fish to man .
18842586	0	zinc	74,78	Wrnip1	6,12	zinc	Wrnip1	MESH:D015032	56897	Chemical	Gene	manner|compound|START_ENTITY factories|nmod|manner localized|nmod|factories localized|nsubj|END_ENTITY	Human Wrnip1 is localized in replication factories in a ubiquitin-binding zinc finger-dependent manner .
12588196	0	zinc	35,39	XPA	69,72	zinc	XPA	MESH:D015032	7507	Chemical	Gene	finger|compound|START_ENTITY Mechanism|nmod|finger Mechanism|nmod|END_ENTITY	Mechanism of nickel assault on the zinc finger of DNA repair protein XPA .
15540943	0	zinc	47,51	XPA	95,98	zinc	XPA	MESH:D015032	7507	Chemical	Gene	finger|compound|START_ENTITY Zn|nmod|finger substitute|nmod|Zn Co|amod|substitute Co|acl|derived derived|nmod|END_ENTITY	Co -LRB- II -RRB- and Cd -LRB- II -RRB- substitute for Zn -LRB- II -RRB- in the zinc finger derived from the DNA repair protein XPA , demonstrating a variety of potential mechanisms of toxicity .
17577569	0	zinc	101,105	XPA	97,100	zinc	XPA	MESH:D015032	7507	Chemical	Gene	finger|compound|START_ENTITY finger|compound|END_ENTITY	Quantitative electrospray ionization mass spectrometry of zinc finger oxidation : the reaction of XPA zinc finger with H -LRB- 2 -RRB- O -LRB- 2 -RRB- .
17577569	0	zinc	58,62	XPA	97,100	zinc	XPA	MESH:D015032	7507	Chemical	Gene	oxidation|compound|START_ENTITY spectrometry|nmod|oxidation spectrometry|dep|reaction reaction|nmod|finger finger|compound|END_ENTITY	Quantitative electrospray ionization mass spectrometry of zinc finger oxidation : the reaction of XPA zinc finger with H -LRB- 2 -RRB- O -LRB- 2 -RRB- .
18171019	0	zinc	20,24	XPA	16,19	zinc	XPA	MESH:D015032	7507	Chemical	Gene	finger|compound|START_ENTITY finger|compound|END_ENTITY	Reaction of the XPA zinc finger with S-nitrosoglutathione .
20680849	0	zinc	82,86	XPA	104,107	zinc	XPA	MESH:D015032	7507	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Biophysical analysis of the interaction of toxic metal ions and oxidants with the zinc finger domain of XPA .
7526200	0	zinc	21,25	XPA	4,7	zinc	XPA	MESH:D015032	7507	Chemical	Gene	metalloprotein|compound|START_ENTITY metalloprotein|nsubj|protein protein|compound|END_ENTITY	The XPA protein is a zinc metalloprotein with an ability to recognize various kinds of DNA damage .
2506074	0	zinc	58,62	Xfin	75,79	zinc	Xfin	MESH:D015032	397958(Tax:8355)	Chemical	Gene	finger|compound|START_ENTITY finger|nmod|END_ENTITY	Complete assignment of the 1H NMR spectrum of a synthetic zinc finger from Xfin .
16760462	0	zinc	39,43	YKE4	0,4	zinc	YKE4	MESH:D015032	854789(Tax:4932)	Chemical	Gene	transporter|compound|START_ENTITY encodes|dobj|transporter encodes|nsubj|END_ENTITY	YKE4 -LRB- YIL023C -RRB- encodes a bidirectional zinc transporter in the endoplasmic reticulum of Saccharomyces_cerevisiae .
26455326	0	zinc	21,25	ZBTB7A	14,20	zinc	ZBTB7A	MESH:D015032	51341	Chemical	Gene	mutations|compound|START_ENTITY mutations|compound|END_ENTITY	Somatic human ZBTB7A zinc finger mutations promote cancer progression .
19303045	0	zinc	73,77	ZC3H14	29,35	zinc	ZC3H14	MESH:D015032	79882	Chemical	Gene	protein|compound|START_ENTITY isoforms|nmod|protein generate|dobj|isoforms generate|nsubj|variants variants|nmod|gene gene|compound|END_ENTITY	Splice variants of the human ZC3H14 gene generate multiple isoforms of a zinc finger polyadenosine RNA binding protein .
25268596	0	zinc	10,14	ZFC3H1	0,6	zinc	ZFC3H1	MESH:D015032	196441	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	ZFC3H1 , a zinc finger protein , modulates IL-8 transcription by binding with celastramycin_A , a potential immune suppressor .
1849423	0	zinc	12,16	ZFY	62,65	zinc	ZFY	MESH:D015032	7544	Chemical	Gene	fingers|compound|START_ENTITY fingers|nmod|END_ENTITY	Alternating zinc fingers in the human male associated protein ZFY : 2D NMR structure of an even finger and implications for `` jumping-linker '' DNA recognition .
1854720	0	zinc	12,16	ZFY	62,65	zinc	ZFY	MESH:D015032	7544	Chemical	Gene	fingers|compound|START_ENTITY fingers|nmod|END_ENTITY	Alternating zinc fingers in the human male associated protein ZFY : refinement of the NMR structure of an even finger by selective deuterium labeling and implications for DNA recognition .
20028140	0	zinc	56,60	ZFY	52,55	zinc	ZFY	MESH:D015032	7544	Chemical	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	Characterization of the DNA binding activity of the ZFY zinc finger domain .
15509557	0	zinc	72,76	ZIP	123,126	zinc	ZIP	MESH:D015032	1613	Chemical	Gene	transporter|compound|START_ENTITY encodes|dobj|transporter encodes|xcomp|related related|nmod|proteins proteins|compound|END_ENTITY	Drosophila fear_of_intimacy encodes a Zrt/IRT-like _ protein -LRB- ZIP -RRB- family zinc transporter functionally related to mammalian ZIP proteins .
15509557	0	zinc	72,76	ZIP	60,63	zinc	ZIP	MESH:D015032	1613	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Drosophila fear_of_intimacy encodes a Zrt/IRT-like _ protein -LRB- ZIP -RRB- family zinc transporter functionally related to mammalian ZIP proteins .
22715365	0	zinc	23,27	ZIP	39,42	zinc	ZIP	MESH:D015032	843276(Tax:3702)	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|END_ENTITY	Modeling regulation of zinc uptake via ZIP transporters in yeast and plant roots .
11301334	0	zinc	36,40	ZIP1	10,14	zinc	ZIP1	MESH:D015032	27173	Chemical	Gene	uptake|compound|START_ENTITY mediates|dobj|uptake mediates|nsubj|transporter transporter|compound|END_ENTITY	The human ZIP1 transporter mediates zinc uptake in human K562 erythroleukemia cells .
16203195	0	zinc	27,31	ZIP1	22,26	zinc	ZIP1	MESH:D015032	27173	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Overexpression of the ZIP1 zinc transporter induces an osteogenic phenotype in mesenchymal stem cells .
17651823	0	zinc	24,28	ZIP1	118,122	zinc	ZIP1	MESH:D015032	100136205(Tax:8022)	Chemical	Gene	uptake|compound|START_ENTITY uptake|nmod|expression expression|nmod|END_ENTITY	Regulation of branchial zinc uptake by 1alpha ,25 - -LRB- OH -RRB- -LRB- 2 -RRB- D -LRB- 3 -RRB- in rainbow_trout and associated changes in expression of ZIP1 and ECaC .
24922175	0	zinc	101,105	ZIP1	29,33	zinc	ZIP1	MESH:D015032	27173	Chemical	Gene	levels|compound|START_ENTITY females|nmod|levels expression|nmod|females expression|compound|END_ENTITY	Zinc fortification decreases ZIP1 gene expression of some adolescent females with appropriate plasma zinc levels .
25089007	0	zinc	40,44	ZIP1	85,89	zinc	ZIP1	MESH:D015032	30791(Tax:10090)	Chemical	Gene	cations|nmod|START_ENTITY effect|nmod|cations uptake|nsubj|effect uptake|nmod|protein_1 protein_1|appos|END_ENTITY	The effect of divalent metal cations on zinc uptake by mouse Zrt/Irt-like _ protein_1 -LRB- ZIP1 -RRB- .
26979775	0	zinc	29,33	ZIP1	78,82	zinc	ZIP1	MESH:D015032	30791(Tax:10090)	Chemical	Gene	activity|compound|START_ENTITY activity|nmod|protein_1 protein_1|appos|END_ENTITY	Oxidative stress upregulates zinc uptake activity via Zrt/Irt-like _ protein_1 -LRB- ZIP1 -RRB- in cultured mouse astrocytes .
15642354	0	zinc	72,76	ZIP14	91,96	zinc	ZIP14	MESH:D015032	23516	Chemical	Gene	transporters|compound|START_ENTITY transporters|appos|END_ENTITY	Structure-function analysis of a novel member of the LIV-1 subfamily of zinc transporters , ZIP14 .
21373779	0	zinc	6,10	ZIP14	0,5	zinc	ZIP14	MESH:D015032	23516	Chemical	Gene	downregulation|compound|START_ENTITY downregulation|compound|END_ENTITY	ZIP14 zinc transporter downregulation and zinc depletion in the development and progression of hepatocellular_cancer .
23110240	0	zinc	44,48	ZIP14	17,22	zinc	ZIP14	MESH:D015032	213053(Tax:10090)	Chemical	Gene	homeostasis|compound|START_ENTITY transporter|nmod|homeostasis transporter|dobj|functions functions|nummod|END_ENTITY	Zinc transporter ZIP14 functions in hepatic zinc , iron and glucose homeostasis during the innate_immune_response -LRB- endotoxemia -RRB- .
25428902	0	zinc	44,48	ZIP14	13,18	zinc	ZIP14	MESH:D015032	213053(Tax:10090)	Chemical	Gene	processing|compound|START_ENTITY Influence|nmod|processing Influence|nmod|END_ENTITY	Influence of ZIP14 -LRB- slc39A14 -RRB- on intestinal zinc processing and barrier function .
21603979	0	zinc	34,38	ZIP2	0,4	zinc	ZIP2	MESH:D015032	29986	Chemical	Gene	fluxes|compound|START_ENTITY mediate|dobj|fluxes mediate|nsubj|END_ENTITY	ZIP2 and ZIP4 mediate age-related zinc fluxes across the retinal pigment epithelium .
24936057	0	zinc	16,20	ZIP2	0,4	zinc	ZIP2	MESH:D015032	29986	Chemical	Gene	transporter|compound|START_ENTITY protein|appos|transporter protein|nummod|END_ENTITY	ZIP2 protein , a zinc transporter , is associated with keratinocyte differentiation .
26643924	0	zinc	55,59	ZIP2	10,14	zinc	ZIP2	MESH:D015032	29986	Chemical	Gene	homeostasis|compound|START_ENTITY polymorphism|nmod|homeostasis polymorphism|nsubj|Effect Effect|nmod|Gln/Arg/Leu Gln/Arg/Leu|compound|END_ENTITY	Effect of ZIP2 Gln/Arg/Leu -LRB- rs2234632 -RRB- polymorphism on zinc homeostasis and inflammatory response following zinc supplementation .
15054103	0	zinc	73,77	ZIP3	68,72	zinc	ZIP3	MESH:D015032	106947(Tax:10090)	Chemical	Gene	transporters|compound|START_ENTITY transporters|compound|END_ENTITY	Zinc-stimulated endocytosis controls activity of the mouse ZIP1 and ZIP3 zinc uptake transporters .
15964816	0	zinc	52,56	ZIP3	76,80	zinc	ZIP3	MESH:D015032	106947(Tax:10090)	Chemical	Gene	lacking|dobj|START_ENTITY mice|acl|lacking Generation|nmod|mice uptake|nsubj|Generation uptake|dobj|END_ENTITY	Generation and characterization of mice lacking the zinc uptake transporter ZIP3 .
21613827	0	zinc	10,14	ZIP3	37,41	zinc	ZIP3	MESH:D015032	29985	Chemical	Gene	START_ENTITY|nmod|zinc zinc|compound|END_ENTITY	Decreased zinc and downregulation of ZIP3 zinc uptake transporter in the development of pancreatic_adenocarcinoma .
25050557	0	zinc	34,38	ZIP3	29,33	zinc	ZIP3	MESH:D015032	29985	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	The cytotoxic role of RREB1 , ZIP3 zinc transporter , and zinc in human pancreatic_adenocarcinoma .
12801924	0	zinc	85,89	ZIP4	38,42	zinc	ZIP4	MESH:D015032	72027(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY encodes|dobj|transporter encodes|nsubj|END_ENTITY	The acrodermatitis_enteropathica gene ZIP4 encodes a tissue-specific , zinc-regulated zinc transporter in mice .
14709598	0	zinc	129,133	ZIP4	124,128	zinc	ZIP4	MESH:D015032	72027(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Acrodermatitis_enteropathica mutations affect transport activity , localization and zinc-responsive trafficking of the mouse ZIP4 zinc transporter .
15358787	0	zinc	33,37	ZIP4	139,143	zinc	ZIP4	MESH:D015032	72027(Tax:10090)	Chemical	Gene	response|nmod|START_ENTITY involves|nsubj|response involves|dobj|localization localization|nmod|END_ENTITY	The adaptive response to dietary zinc in mice involves the differential cellular localization and zinc regulation of the zinc transporters ZIP4 and ZIP5 .
16986515	0	zinc	11,15	ZIP4	38,42	zinc	ZIP4	MESH:D015032	55630	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of zinc on mRNA expression of ZIP4 in Caco2 cells -RSB- .
20160059	0	zinc	86,90	ZIP4	0,4	zinc	ZIP4	MESH:D015032	55630	Chemical	Gene	CREB|compound|START_ENTITY activating|nmod|CREB regulates|advcl|activating regulates|nsubj|END_ENTITY	ZIP4 regulates pancreatic_cancer cell growth by activating IL-6 / STAT3 pathway through zinc finger transcription factor CREB .
20463217	0	zinc	67,71	ZIP4	113,117	zinc	ZIP4	MESH:D015032	72027(Tax:10090)	Chemical	Gene	sequestration|nmod|START_ENTITY alters|dobj|sequestration alters|nmod|interaction interaction|nmod|END_ENTITY	Tissue_plasminogen_activator alters intracellular sequestration of zinc through interaction with the transporter ZIP4 .
26385990	0	zinc	118,122	ZIP4	39,43	zinc	ZIP4	MESH:D015032	55630	Chemical	Gene	absorption|compound|START_ENTITY enhance|dobj|absorption increase|advcl|enhance increase|dobj|abundance abundance|compound|END_ENTITY	Soybean extracts increase cell surface ZIP4 abundance and cellular zinc levels : a potential novel strategy to enhance zinc absorption by ZIP4-targeting .
15705588	0	zinc	34,38	ZIP7	4,8	zinc	ZIP7	MESH:D015032	7922	Chemical	Gene	transporter|compound|START_ENTITY encodes|dobj|transporter encodes|nsubj|gene gene|compound|END_ENTITY	The ZIP7 gene -LRB- Slc39a7 -RRB- encodes a zinc transporter involved in zinc homeostasis of the Golgi apparatus .
22563477	0	zinc	5,9	ZIP8	0,4	zinc	ZIP8	MESH:D015032	67547(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	ZIP8 zinc transporter : indispensable role for both multiple-organ organogenesis and hematopoiesis in utero .
25014354	0	zinc	79,83	ZIP9	74,78	zinc	ZIP9	MESH:D015032	55334	Chemical	Gene	subfamily|compound|START_ENTITY subfamily|compound|END_ENTITY	Identification and characterization of membrane androgen receptors in the ZIP9 zinc transporter subfamily : I. Discovery in female atlantic croaker and evidence ZIP9 mediates testosterone-induced apoptosis of ovarian follicle cells .
25014355	0	zinc	79,83	ZIP9	74,78	zinc	ZIP9	MESH:D015032	55334	Chemical	Gene	subfamily|compound|START_ENTITY subfamily|compound|END_ENTITY	Identification and characterization of membrane androgen receptors in the ZIP9 zinc transporter subfamily : II .
10667597	0	zinc	13,17	ZK7	0,3	zinc	ZK7	MESH:D015032	7678	Chemical	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	ZK7 , a novel zinc finger gene , is induced by vascular_endothelial_growth_factor and inhibits apoptotic death in hematopoietic cells .
17934332	0	zinc	30,34	ZNF133	51,57	zinc	ZNF133	MESH:D015032	7692	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	PIAS1 interacts with the KRAB zinc finger protein , ZNF133 , via zinc finger motifs and regulates its transcriptional activity .
17934332	0	zinc	63,67	ZNF133	51,57	zinc	ZNF133	MESH:D015032	7692	Chemical	Gene	motifs|compound|START_ENTITY protein|nmod|motifs protein|appos|END_ENTITY	PIAS1 interacts with the KRAB zinc finger protein , ZNF133 , via zinc finger motifs and regulates its transcriptional activity .
7490084	0	zinc	28,32	ZNF165	46,52	zinc	ZNF165	MESH:D015032	7718	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Characterization of a novel zinc finger gene -LRB- ZNF165 -RRB- mapping to 6p21 that is expressed specifically in testis .
9073517	0	zinc	43,47	ZNF184	61,67	zinc	ZNF184	MESH:D015032	7738	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Identification of a novel Krueppel-related zinc finger gene -LRB- ZNF184 -RRB- mapping to 6p21 .3 .
17027752	0	zinc	10,14	ZNF198	0,6	zinc	ZNF198	MESH:D015032	7750	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	ZNF198 , a zinc finger protein rearranged in myeloproliferative_disease , localizes to the PML nuclear bodies and interacts with SUMO-1 and PML .
18806873	0	zinc	82,86	ZNF198	0,6	zinc	ZNF198	MESH:D015032	7750	Chemical	Gene	fingers|compound|START_ENTITY stabilizes|nmod|fingers stabilizes|nsubj|END_ENTITY	ZNF198 stabilizes the LSD1-CoREST-HDAC1 complex on chromatin through its MYM-type zinc fingers .
16940172	0	zinc	41,45	ZNF217	24,30	zinc	ZNF217	MESH:D015032	7764	Chemical	Gene	proteins|compound|START_ENTITY proteins|compound|END_ENTITY	Specific recognition of ZNF217 and other zinc finger proteins at a surface groove of C-terminal binding proteins .
23436653	0	zinc	37,41	ZNF217	101,107	zinc	ZNF217	MESH:D015032	7764	Chemical	Gene	fingers|compound|START_ENTITY recognition|nmod|fingers insights|nmod|recognition revealed|nsubj|insights revealed|nmod|analysis analysis|nmod|END_ENTITY	New insights into DNA recognition by zinc fingers revealed by structural analysis of the oncoprotein ZNF217 .
2004757	0	zinc	38,42	ZNF24	65,70	zinc	ZNF24	MESH:D015032	7572	Chemical	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	Chromosomal localization of two human zinc finger protein genes , ZNF24 -LRB- KOX17 -RRB- and ZNF29 -LRB- KOX26 -RRB- , to 18q12 and 17p13-p12 , respectively .
25133527	0	zinc	106,110	ZNF261	122,128	zinc	ZNF261	MESH:D015032	9203	Chemical	Gene	fingers|compound|START_ENTITY fingers|nmod|END_ENTITY	Characterization of the SUMO-binding activity of the myeloproliferative and mental_retardation -LRB- MYM -RRB- - type zinc fingers in ZNF261 and ZNF198 .
12657633	0	zinc	21,25	ZNF265	67,73	zinc	ZNF265	MESH:D015032	9406	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	The structure of the zinc finger domain from human splicing factor ZNF265 fold .
11311945	0	zinc	54,58	ZNF268	72,78	zinc	ZNF268	MESH:D015032	10795	Chemical	Gene	gene|compound|START_ENTITY Cloning|nmod|gene Cloning|appos|END_ENTITY	Cloning and characterization of a novel Kr ppel-like zinc finger gene , ZNF268 , expressed in early human embryo .
15547661	0	zinc	29,33	ZNF268	0,6	zinc	ZNF268	MESH:D015032	10795	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	ZNF268 , a novel kruppel-like zinc finger protein , is implicated in early human liver development .
16787922	0	zinc	23,27	ZNF268	35,41	zinc	ZNF268	MESH:D015032	10795	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Transcription of human zinc finger ZNF268 gene requires an intragenic promoter element .
16865230	0	zinc	16,20	ZNF268	33,39	zinc	ZNF268	MESH:D015032	10795	Chemical	Gene	gene|compound|START_ENTITY gene|amod|multiple multiple|nmod:npmod|encodes encodes|nummod|END_ENTITY	KRAB-containing zinc finger gene ZNF268 encodes multiple alternatively spliced isoforms that contain transcription regulatory domains .
18949428	0	zinc	39,43	ZNF268	56,62	zinc	ZNF268	MESH:D015032	10795	Chemical	Gene	gene|compound|START_ENTITY splicing|nmod|gene END_ENTITY|nsubj|splicing	Aberrant alternative splicing of human zinc finger gene ZNF268 in human hematological_malignancy .
16817023	0	zinc	63,67	ZNF284L	81,88	zinc	ZNF284L	MESH:D015032	342909	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Cloning and characterization of a novel KRAB-domain-containing zinc finger gene -LRB- ZNF284L -RRB- .
12051768	0	zinc	36,40	ZNF304	57,63	zinc	ZNF304	MESH:D015032	57343	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Identification of a KRAB-containing zinc finger protein , ZNF304 , by AU-motif-directed display method and initial characterization in lymphocyte activation .
16806083	0	zinc	22,26	ZNF325	0,6	zinc	ZNF325	MESH:D015032	7559	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	ZNF325 , a novel human zinc finger protein with a RBaK-like RB-binding domain , inhibits AP-1 - and SRE-mediated transcriptional activity .
12127974	0	zinc	49,53	ZNF359	68,74	zinc	ZNF359	MESH:D015032	7571	Chemical	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	Identification and characterization of two novel zinc finger genes , ZNF359 and ZFP28 , in human development .
18084723	0	zinc	32,36	ZNF418	0,6	zinc	ZNF418	MESH:D015032	147686	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	ZNF418 , a novel human KRAB/C2H2 zinc finger protein , suppresses MAPK signaling pathway .
17646705	0	zinc	38,42	ZNF435	0,6	zinc	ZNF435	MESH:D015032	80345	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	ZNF435 , a novel human SCAN-containing zinc finger protein , inhibits AP-1-mediated transcriptional activation .
17669267	0	zinc	32,36	ZNF438	50,56	zinc	ZNF438	MESH:D015032	220929	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Identification of a novel human zinc finger gene , ZNF438 , with transcription inhibition activity .
16966434	0	zinc	16,20	ZNF652	0,6	zinc	ZNF652	MESH:D015032	22834	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	ZNF652 , a novel zinc finger protein , interacts with the putative breast_tumor suppressor CBFA2T3 to repress transcription .
9839802	0	zinc	34,38	ZNF85	23,28	zinc	ZNF85	MESH:D015032	7639	Chemical	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Functional analysis of ZNF85 KRAB zinc finger protein , a member of the highly homologous ZNF91 family .
20162441	0	zinc	42,46	ZNFD	60,64	zinc	ZNFD	MESH:D015032	340069	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Isolation and characterization of a novel zinc finger gene , ZNFD , activating AP1 -LRB- PMA -RRB- transcriptional activities .
22231842	0	zinc	63,67	ZNFD	83,87	zinc	ZNFD	MESH:D015032	225497(Tax:10090)	Chemical	Gene	protein|compound|START_ENTITY HSE|nmod|protein activity|nmod|HSE Activation|nmod|activity END_ENTITY|nsubj|Activation	Activation of transcriptional activity of HSE by a novel mouse zinc finger protein ZNFD specifically expressed in testis .
11777961	0	zinc	46,50	ZNFEB	64,69	zinc	ZNFEB	MESH:D015032	10778	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Sustained expression of the novel EBV-induced zinc finger gene , ZNFEB , is critical for the transition of B lymphocyte activation to oncogenic growth transformation .
10662553	0	zinc	6,10	ZNRD1	24,29	zinc	ZNRD1	MESH:D015032	30834	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A new zinc ribbon gene -LRB- ZNRD1 -RRB- is cloned from the human MHC class I region .
20192730	0	zinc	7,11	ZNRD1	0,5	zinc	ZNRD1	MESH:D015032	30834	Chemical	Gene	domain-containing|compound|START_ENTITY END_ENTITY|dep|domain-containing	ZNRD1 -LRB- zinc ribbon domain-containing 1 -RRB- is a host cellular factor that influences HIV-1 replication and disease progression .
10677350	0	zinc	75,79	ZRT1	70,74	zinc	ZRT1	MESH:D015032	852637(Tax:4932)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Zinc-regulated ubiquitin conjugation signals endocytosis of the yeast ZRT1 zinc transporter .
8637895	0	zinc	101,105	ZRT1	10,14	zinc	ZRT1	MESH:D015032	852637(Tax:4932)	Chemical	Gene	limitation|compound|START_ENTITY induced|nmod|limitation system|acl|induced protein|nmod|system encodes|dobj|protein encodes|nsubj|gene gene|compound|END_ENTITY	The yeast ZRT1 gene encodes the zinc transporter protein of a high-affinity uptake system induced by zinc limitation .
8637895	0	zinc	32,36	ZRT1	10,14	zinc	ZRT1	MESH:D015032	852637(Tax:4932)	Chemical	Gene	protein|compound|START_ENTITY encodes|dobj|protein encodes|nsubj|gene gene|compound|END_ENTITY	The yeast ZRT1 gene encodes the zinc transporter protein of a high-affinity uptake system induced by zinc limitation .
9786854	0	zinc	44,48	ZRT1	39,43	zinc	ZRT1	MESH:D015032	852637(Tax:4932)	Chemical	Gene	transporter|compound|START_ENTITY transporter|compound|END_ENTITY	Zinc-induced inactivation of the yeast ZRT1 zinc transporter occurs through endocytosis and vacuolar_degradation .
8798516	0	zinc	39,43	ZRT2	4,8	zinc	ZRT2	MESH:D015032	850821(Tax:4932)	Chemical	Gene	transporter|compound|START_ENTITY encodes|dobj|transporter encodes|nsubj|gene gene|compound|END_ENTITY	The ZRT2 gene encodes the low affinity zinc transporter in Saccharomyces_cerevisiae .
10196477	0	zinc	45,49	ZT2	70,73	zinc	ZT2	MESH:D015032	22651(Tax:10090)	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Isolation and characterization of the murine zinc finger coding gene , ZT2 : expression in normal and transformed myogenic cells .
8808410	0	zinc	69,73	ZT3	56,59	zinc	ZT3	MESH:D015032	22720(Tax:10090)	Chemical	Gene	factor|compound|START_ENTITY END_ENTITY|appos|factor	Differentiation dependent expression in muscle cells of ZT3 , a novel zinc finger factor differentially expressed in embryonic and adult tissues .
16600381	0	zinc	14,18	ZXDC	0,4	zinc	ZXDC	MESH:D015032	79364	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	ZXDC , a novel zinc finger protein that binds CIITA and activates MHC gene transcription .
2574853	0	zinc	70,74	Zfp-1	54,59	zinc	Zfp-1	MESH:D015032	22640(Tax:10090)	Chemical	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	Structure , expression and chromosomal localization of Zfp-1 , a murine zinc finger protein gene .
9034307	0	zinc	106,110	Zfp64	97,102	zinc	Zfp64	MESH:D015032	22722(Tax:10090)	Chemical	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	A search for a mammalian homologue of the Drosophila photoreceptor development gene glass yields Zfp64 , a zinc finger encoding gene which maps to the distal end of mouse chromosome 2 .
18795322	0	zinc	5,9	Zic	35,38	zinc	Zic	MESH:D015032	7235274(Tax:7739)	Chemical	Gene	genes|compound|START_ENTITY genes|nmod|SP SP|appos|END_ENTITY	C2H2 zinc finger genes of the Gli , Zic , KLF , SP , Wilms ' _ tumour , Huckebein , Snail , Ovo , Spalt , Odd , Blimp-1 , Fez and related gene families from Branchiostoma_floridae .
10383437	1	zinc	129,133	Zif268	122,128	zinc	Zif268	MESH:D015032	1958	Chemical	Gene	complex|compound|START_ENTITY complex|amod|END_ENTITY	Contribution of individual side chains to binding affinity and specificity in the Zif268 zinc finger-DNA complex .
23322169	0	zinc	79,83	Zip	132,135	zinc	Zip	MESH:D015032	38002(Tax:7227)	Chemical	Gene	activities|compound|START_ENTITY activities|nmod|most most|nmod|END_ENTITY	In vivo zinc toxicity phenotypes provide a sensitized background that suggests zinc transport activities for most of the Drosophila Zip and ZnT genes .
23322169	0	zinc	8,12	Zip	132,135	zinc	Zip	MESH:D015032	38002(Tax:7227)	Chemical	Gene	provide|nmod|START_ENTITY provide|dobj|background background|acl:relcl|suggests suggests|dobj|activities activities|nmod|most most|nmod|END_ENTITY	In vivo zinc toxicity phenotypes provide a sensitized background that suggests zinc transport activities for most of the Drosophila Zip and ZnT genes .
19003164	0	zinc	44,48	Zip14	61,66	zinc	Zip14	MESH:D015032	213053(Tax:10090)	Chemical	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	Restraint stress up-regulates expression of zinc transporter Zip14 mRNA in mouse liver .
19179618	0	zinc	98,102	Zip14	115,120	zinc	Zip14	MESH:D015032	213053(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY activity|nmod|transporter nitric_oxide|nmod|activity END_ENTITY|amod|nitric_oxide	Interleukin-1beta contributes via nitric_oxide to the upregulation and functional activity of the zinc transporter Zip14 -LRB- Slc39a14 -RRB- in murine hepatocytes .
21653899	0	zinc	121,125	Zip14	0,5	zinc	Zip14	MESH:D015032	213053(Tax:10090)	Chemical	Gene	iron|compound|START_ENTITY uptake|nmod|iron roles|nmod|uptake support|dobj|roles transporter|acl:relcl|support transporter|nsubj|END_ENTITY	Zip14 is a complex broad-scope metal-ion transporter whose functional properties support roles in the cellular uptake of zinc and nontransferrin-bound iron .
18385089	0	zinc	73,77	Zip2	65,69	zinc	Zip2	MESH:D015032	29986	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	Modulation of Nrf2-dependent antioxidant functions in the RPE by Zip2 , a zinc transporter protein .
15634741	0	zinc	27,31	Zip3	0,4	zinc	Zip3	MESH:D015032	29985	Chemical	Gene	uptake|compound|START_ENTITY role|nmod|uptake plays|dobj|role plays|nsubj|END_ENTITY	Zip3 plays a major role in zinc uptake into mammary epithelial cells and is regulated by prolactin .
19458277	0	zinc	28,32	Zip3	0,4	zinc	Zip3	MESH:D015032	106947(Tax:10090)	Chemical	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	Zip3 -LRB- Slc39a3 -RRB- functions in zinc reuptake from the alveolar lumen in lactating mammary gland .
24303081	0	zinc	57,61	Zip5	21,25	zinc	Zip5	MESH:D015032	72002(Tax:10090)	Chemical	Gene	excretion|compound|START_ENTITY regulates|dobj|excretion regulates|nsubj|END_ENTITY	The zinc transporter Zip5 -LRB- Slc39a5 -RRB- regulates intestinal zinc excretion and protects the pancreas against zinc_toxicity .
18272141	0	zinc	23,27	Zip6	0,4	zinc	Zip6	MESH:D015032	25800	Chemical	Gene	uptake|compound|START_ENTITY regulates|dobj|uptake regulates|nsubj|END_ENTITY	Zip6 -LRB- LIV-1 -RRB- regulates zinc uptake in neuroblastoma cells under resting but not depolarizing conditions .
16782067	0	zinc	23,27	Zipzap/p200	0,11	zinc	Zipzap/p200	MESH:D015032	196528	Chemical	Gene	protein|compound|START_ENTITY protein|nsubj|END_ENTITY	Zipzap/p200 is a novel zinc finger protein contributing to cardiac gene regulation .
11984815	0	zinc	20,24	ZnT-1	37,42	zinc	ZnT-1	MESH:D015032	22782(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY Distribution|nmod|transporter END_ENTITY|nsubj|Distribution	Distribution of the zinc transporter ZnT-1 in comparison with chelatable zinc in the mouse brain .
12220707	7	zinc	1200,1204	ZnT-1	1160,1165	zinc	ZnT-1	MESH:D015032	22782(Tax:10090)	Chemical	Gene	together|nmod|START_ENTITY indicates|advmod|together indicates|nsubj|regulation regulation|nmod|expression expression|compound|END_ENTITY	The striking developmental regulation of ZnT-1 expression together with synaptic zinc indicates that ZnT-1 may play a key role in protecting developing neurons against potentially toxic zinc .
12220707	7	zinc	1305,1309	ZnT-1	1160,1165	zinc	ZnT-1	MESH:D015032	22782(Tax:10090)	Chemical	Gene	neurons|nmod|START_ENTITY protecting|dobj|neurons play|advcl|protecting indicates|ccomp|play indicates|nsubj|regulation regulation|nmod|expression expression|compound|END_ENTITY	The striking developmental regulation of ZnT-1 expression together with synaptic zinc indicates that ZnT-1 may play a key role in protecting developing neurons against potentially toxic zinc .
15378655	0	zinc	54,58	ZnT-1	0,5	zinc	ZnT-1	MESH:D015032	7779	Chemical	Gene	toxicity|compound|START_ENTITY protects|nmod|toxicity protects|nsubj|expression expression|amod|END_ENTITY	ZnT-1 expression in astroglial cells protects against zinc toxicity and slows the accumulation of intracellular zinc .
17971500	0	zinc	14,18	ZnT-1	107,112	zinc	ZnT-1	MESH:D015032	7779	Chemical	Gene	homeostasis|compound|START_ENTITY regulated|nsubjpass|homeostasis regulated|nmod|expression expression|nmod|exporters exporters|amod|ZnT-9 ZnT-9|amod|END_ENTITY	Intracellular zinc homeostasis in leukocyte subsets is regulated by different expression of zinc exporters ZnT-1 to ZnT-9 .
17971500	0	zinc	92,96	ZnT-1	107,112	zinc	ZnT-1	MESH:D015032	7779	Chemical	Gene	exporters|compound|START_ENTITY exporters|amod|ZnT-9 ZnT-9|amod|END_ENTITY	Intracellular zinc homeostasis in leukocyte subsets is regulated by different expression of zinc exporters ZnT-1 to ZnT-9 .
19371353	0	zinc	15,19	ZnT-1	41,46	zinc	ZnT-1	MESH:D015032	7779	Chemical	Gene	proteins|compound|START_ENTITY proteins|amod|END_ENTITY	Alterations of zinc transporter proteins ZnT-1 , ZnT-4 and ZnT-6 in preclinical Alzheimer 's _ disease brain .
20392624	0	zinc	100,104	ZnT-1	94,99	zinc	ZnT-1	MESH:D015032	7779	Chemical	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Increased level of exogenous zinc induces cytotoxicity and up-regulates the expression of the ZnT-1 zinc transporter gene in pancreatic_cancer cells .
20392624	0	zinc	29,33	ZnT-1	94,99	zinc	ZnT-1	MESH:D015032	7779	Chemical	Gene	level|nmod|START_ENTITY induces|nsubj|level induces|dobj|expression expression|nmod|gene gene|compound|END_ENTITY	Increased level of exogenous zinc induces cytotoxicity and up-regulates the expression of the ZnT-1 zinc transporter gene in pancreatic_cancer cells .
24951051	0	zinc	15,19	ZnT-1	0,5	zinc	ZnT-1	MESH:D015032	7779	Chemical	Gene	extrudes|dobj|START_ENTITY extrudes|nsubj|END_ENTITY	ZnT-1 extrudes zinc from mammalian cells functioning as a Zn -LRB- 2 + -RRB- / H -LRB- + -RRB- exchanger .
9254680	0	zinc	14,18	ZnT-1	37,42	zinc	ZnT-1	MESH:D015032	58976(Tax:10116)	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Expression of zinc transporter gene , ZnT-1 , is induced after transient forebrain_ischemia in the gerbil .
9560190	0	zinc	18,22	ZnT-1	35,40	zinc	ZnT-1	MESH:D015032	7779	Chemical	Gene	transporter|compound|START_ENTITY Regulation|nmod|transporter END_ENTITY|nsubj|Regulation	Regulation of the zinc transporter ZnT-1 by dietary zinc .
17065149	0	zinc	71,75	ZnT-2	41,46	zinc	ZnT-2	MESH:D015032	7780	Chemical	Gene	women|nmod|START_ENTITY END_ENTITY|nmod|women	Identification of a mutation in SLC30A2 -LRB- ZnT-2 -RRB- in women with low milk zinc concentration that results in transient neonatal_zinc_deficiency .
22733820	0	zinc	54,58	ZnT-2	72,77	zinc	ZnT-2	MESH:D015032	7780	Chemical	Gene	transporter|compound|START_ENTITY mutation|nmod|transporter mutation|appos|END_ENTITY	A dominant negative heterozygous G87R mutation in the zinc transporter , ZnT-2 -LRB- SLC30A2 -RRB- , results in transient_neonatal_zinc_deficiency .
8617223	0	zinc	54,58	ZnT-2	0,5	zinc	ZnT-2	MESH:D015032	7780	Chemical	Gene	confers|nmod|START_ENTITY protein|acl:relcl|confers END_ENTITY|appos|protein	ZnT-2 , a mammalian protein that confers resistance to zinc by facilitating vesicular sequestration .
15331542	0	zinc	51,55	ZnT-8	69,74	zinc	ZnT-8	MESH:D015032	169026	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Identification and cloning of a beta-cell-specific zinc transporter , ZnT-8 , localized into insulin secretory granules .
16158222	0	zinc	39,43	ZnT-8	0,5	zinc	ZnT-8	MESH:D015032	169026	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|appos|transporter	ZnT-8 , a pancreatic beta-cell-specific zinc transporter .
20525392	0	zinc	50,54	ZnT-8	68,73	zinc	ZnT-8	MESH:D015032	169026	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Three-dimensional structure of beta-cell-specific zinc transporter , ZnT-8 , predicted from the type 2 diabetes-associated gene variant SLC30A8 R325W .
21866305	0	zinc	8,12	ZnT3	0,4	zinc	ZnT3	MESH:D015032	7781	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|dep|transporter	ZnT3 : a zinc transporter active in several organs .
22427991	0	zinc	24,28	ZnT3	73,77	zinc	ZnT3	MESH:D015032	7781	Chemical	Gene	transporters|nsubj|START_ENTITY transporters|dobj|END_ENTITY	Angiotensin_II requires zinc and downregulation of the zinc transporters ZnT3 and ZnT10 to induce senescence of vascular smooth muscle cells .
23839275	0	zinc	73,77	ZnT3	68,72	zinc	ZnT3	MESH:D015032	7781	Chemical	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	A comparative study on the possible zinc binding sites of the human ZnT3 zinc transporter protein .
17355957	0	zinc	34,38	ZnT5	0,4	zinc	ZnT5	MESH:D015032	64924	Chemical	Gene	transporter|compound|START_ENTITY transporter|nsubj|B B|compound|END_ENTITY	ZnT5 variant B is a bidirectional zinc transporter and mediates zinc uptake in human intestinal Caco-2 cells .
19245740	0	zinc	114,118	ZnT5	42,46	zinc	ZnT5	MESH:D015032	64924	Chemical	Gene	status|compound|START_ENTITY decline|nmod|status contribute|nmod|decline zinc|acl:relcl|contribute zinc|appos|END_ENTITY	Does promoter methylation of the SLC30A5 -LRB- ZnT5 -RRB- zinc transporter gene contribute to the ageing-related decline in zinc status ?
11997387	0	zinc	49,53	ZnT6	67,71	zinc	ZnT6	MESH:D015032	55676	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Functional characterization of a novel mammalian zinc transporter , ZnT6 .
12446736	0	zinc	24,28	ZnT7	0,4	zinc	ZnT7	MESH:D015032	148867	Chemical	Gene	transporter|compound|START_ENTITY END_ENTITY|appos|transporter	ZnT7 , a novel mammalian zinc transporter , accumulates zinc in the Golgi apparatus .
12446736	0	zinc	54,58	ZnT7	0,4	zinc	ZnT7	MESH:D015032	148867	Chemical	Gene	accumulates|dobj|START_ENTITY accumulates|nsubj|END_ENTITY	ZnT7 , a novel mammalian zinc transporter , accumulates zinc in the Golgi apparatus .
16984975	0	zinc	58,62	ZnT8	75,79	zinc	ZnT8	MESH:D015032	169026	Chemical	Gene	transporter|compound|START_ENTITY characterization|nmod|transporter END_ENTITY|nsubj|characterization	In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion .
19706465	0	zinc	35,39	ZnT8	52,56	zinc	ZnT8	MESH:D015032	239436(Tax:10090)	Chemical	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Insulin crystallization depends on zinc transporter ZnT8 expression , but is not required for normal glucose homeostasis in mice .
23039265	0	zinc	62,66	ZnT8	80,84	zinc	ZnT8	MESH:D015032	169026	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|W W|compound|END_ENTITY	Long-term sustained autoimmune response to beta cell specific zinc transporter -LRB- ZnT8 , W , R , Q -RRB- in young adult patients with preserved beta cell function at diagnosis of diabetes .
12163020	0	zinc	19,23	Znf131	36,42	zinc	Znf131	MESH:D015032	72465(Tax:10090)	Chemical	Gene	finger|compound|START_ENTITY finger|dep|END_ENTITY	The murine BTB/POZ zinc finger gene Znf131 : predominant expression in the developing central nervous system , in adult brain , testis , and thymus .
12095919	0	zinc	68,72	Znt5	91,95	zinc	Znt5	MESH:D015032	69048(Tax:10090)	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Osteopenia and male-specific sudden_cardiac_death in mice lacking a zinc transporter gene , Znt5 .
24770585	0	zinc	17,21	Znt7	93,97	zinc	Znt7	MESH:D015032	66500(Tax:10090)	Chemical	Gene	status|compound|START_ENTITY Linking|dobj|status Linking|parataxis|mapping mapping|nmod|mice mice|amod|END_ENTITY	Linking cellular zinc status to body weight and fat mass : mapping quantitative trait loci in Znt7 knockout mice .
21824264	0	zinc	36,40	Znt8	75,79	zinc	Znt8	MESH:D015032	239436(Tax:10090)	Chemical	Gene	secretion|nmod|START_ENTITY Regulation|nmod|secretion Regulation|dep|lessons lessons|nmod|model model|amod|END_ENTITY	Regulation of glucagon secretion by zinc : lessons from the b cell-specific Znt8 knockout mouse model .
21250939	0	zinc	40,44	Zrg17	34,39	zinc	Zrg17	MESH:D015032	855775(Tax:4932)	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	Transcriptional regulation of the Zrg17 zinc transporter of the yeast secretory pathway .
12893829	0	zinc	121,125	Zrt1	32,36	zinc	Zrt1	MESH:D015032	852637(Tax:4932)	Chemical	Gene	required|nmod|START_ENTITY required|nsubjpass|domain domain|nmod|transporter transporter|amod|END_ENTITY	A cytosolic domain of the yeast Zrt1 zinc transporter is required for its post-translational inactivation in response to zinc and cadmium .
12893829	0	zinc	37,41	Zrt1	32,36	zinc	Zrt1	MESH:D015032	852637(Tax:4932)	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	A cytosolic domain of the yeast Zrt1 zinc transporter is required for its post-translational inactivation in response to zinc and cadmium .
20580786	0	zinc	55,59	acid-sensing_ion_channel_3	25,51	zinc	acid-sensing ion channel 3	MESH:D015032	9311	Chemical	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Inhibitory regulation of acid-sensing_ion_channel_3 by zinc .
11321959	0	zinc	11,15	adrenocorticotropic_hormone	19,46	zinc	adrenocorticotropic hormone	MESH:D015032	18976(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	-LSB- Effect of zinc on adrenocorticotropic_hormone secretion in the pituitary cell line AtT-20 -RSB- .
7716168	0	zinc	98,102	alcohol_dehydrogenase	34,55	zinc	alcohol dehydrogenase	MESH:D015032	10327	Chemical	Gene	ion|compound|START_ENTITY ion|amod|END_ENTITY	Molecular dynamics simulations of alcohol_dehydrogenase with a four - or five-coordinate catalytic zinc ion .
8727676	0	zinc	57,61	alkaline_phosphatase	15,35	zinc	alkaline phosphatase	MESH:D015032	250	Chemical	Gene	status|compound|START_ENTITY marker|nmod|status marker|nsubj|activity activity|compound|END_ENTITY	Is erythrocyte alkaline_phosphatase activity a marker of zinc status in humans ?
9914326	0	zinc	11,15	alkaline_phosphatase	34,54	zinc	alkaline phosphatase	MESH:D015032	250	Chemical	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of zinc on human skeletal alkaline_phosphatase activity in vitro .
6469988	0	zinc	34,38	alpha-lactalbumin	76,93	zinc	alpha-lactalbumin	MESH:D015032	281894(Tax:9913)	Chemical	Gene	START_ENTITY|amod|binding binding|nmod|END_ENTITY	Conformational changes induced by zinc and terbium binding to native bovine alpha-lactalbumin and calcium-free alpha-lactalbumin .
11256475	0	zinc	88,92	aminopeptidase_N	14,30	zinc	aminopeptidase N	MESH:D015032	290	Chemical	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of aminopeptidase_N -LRB- AP-N -RRB- and urokinase-type_plasminogen_activator -LRB- uPA -RRB- by zinc suppresses the invasion activity in human urological_cancer cells .
9602161	0	zinc	119,123	aminopeptidase_N	20,36	zinc	aminopeptidase N	MESH:D015032	100127099(Tax:7091)	Chemical	Gene	enzyme|compound|START_ENTITY membrane|nmod|enzyme membrane|nsubj|Characterization Characterization|nmod|END_ENTITY	Characterization of aminopeptidase_N from the brush border membrane of the larvae midgut of silkworm , Bombyx_mori as a zinc enzyme .
2542744	0	zinc	10,14	angiotensin_I-converting_enzyme	28,59	zinc	angiotensin I-converting enzyme	MESH:D015032	24310(Tax:10116)	Chemical	Gene	depletion|compound|START_ENTITY depletion|nmod|END_ENTITY	Effect of zinc depletion on angiotensin_I-converting_enzyme in arterial walls and plasma of the rat .
15272608	0	zinc	22,26	beta-hexosaminidase	30,49	zinc	beta-hexosaminidase	MESH:D015032	154968(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|release release|amod|END_ENTITY	-LSB- Inhibitory effect of zinc on beta-hexosaminidase release from RBL-2H3 cells by synthetic chemicals -RSB- .
23030313	0	zinc	11,15	carbonic_anhydrase_II	38,59	zinc	carbonic anhydrase II	MESH:D015032	760	Chemical	Gene	coordination|compound|START_ENTITY coordination|nmod|END_ENTITY	Revisiting zinc coordination in human carbonic_anhydrase_II .
8399158	0	zinc	39,43	carbonic_anhydrase_II	66,87	zinc	carbonic anhydrase II	MESH:D015032	760	Chemical	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Engineering a cysteine ligand into the zinc binding site of human carbonic_anhydrase_II .
8399159	0	zinc	35,39	carbonic_anhydrase_II	62,83	zinc	carbonic anhydrase II	MESH:D015032	760	Chemical	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Structure of an engineered His3Cys zinc binding site in human carbonic_anhydrase_II .
8431430	0	zinc	16,20	carbonic_anhydrase_II	43,64	zinc	carbonic anhydrase II	MESH:D015032	760	Chemical	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Engineering the zinc binding site of human carbonic_anhydrase_II : structure of the His-94 -- > Cys apoenzyme in a new crystalline form .
9398308	0	zinc	54,58	carbonic_anhydrase_II	75,96	zinc	carbonic anhydrase II	MESH:D015032	760	Chemical	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Histidine -- > carboxamide ligand substitutions in the zinc binding site of carbonic_anhydrase_II alter metal coordination geometry but retain catalytic activity .
22465027	0	zinc	8,12	carbonic_anhydrase_IX	38,59	zinc	carbonic anhydrase IX	MESH:D015032	768	Chemical	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of zinc in catalytic activity of carbonic_anhydrase_IX .
24643997	0	zinc	62,66	caspase-3	84,93	zinc	caspase-3	MESH:D015032	836	Chemical	Gene	sites|compound|START_ENTITY sites|nmod|END_ENTITY	The bioinorganic chemistry of apoptosis : potential inhibitory zinc binding sites in caspase-3 .
19448268	0	zinc	53,57	cdf-2	38,43	zinc	cdf-2	MESH:D015032	188574(Tax:6239)	Chemical	Gene	metabolism|compound|START_ENTITY metabolism|amod|END_ENTITY	The cation diffusion facilitator gene cdf-2 mediates zinc metabolism in Caenorhabditis_elegans .
10529385	0	zinc	67,71	ciz1	88,92	zinc	ciz1	MESH:D015032	25792	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Cloning and characterization of a novel p21 -LRB- Cip1/Waf1 -RRB- - interacting zinc finger protein , ciz1 .
24036956	0	zinc	37,41	coat_protein	80,92	zinc	coat protein	MESH:D015032	962660(Tax:12317)	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	The N-terminal region containing the zinc finger domain of tobacco_streak_virus coat_protein is essential for the formation of virus-like particles .
20939487	0	zinc	15,19	cyclin_D2	41,50	zinc	cyclin D2	MESH:D015032	894	Chemical	Gene	START_ENTITY|nmod|concentrations concentrations|nmod|END_ENTITY	-LSB- Influences of zinc on concentrations of cyclin_D2 and cyclin-dependent_kinase_4 of human umbilical cord blood-derived mesenchymal stem cells -RSB- .
10944488	0	zinc	50,54	cysteine-rich_intestinal_protein	14,46	zinc	cysteine-rich intestinal protein	MESH:D015032	12925(Tax:10090)	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	Regulation of cysteine-rich_intestinal_protein , a zinc finger protein , by mediators of the immune response .
8283289	0	zinc	93,97	cysteine-rich_intestinal_protein	14,46	zinc	cysteine-rich intestinal protein	MESH:D015032	691657(Tax:10116)	Chemical	Gene	dependent|advmod|START_ENTITY dependent|nsubj|Expression Expression|nmod|END_ENTITY	Expression of cysteine-rich_intestinal_protein in rat intestine and transfected cells is not zinc dependent .
26545796	0	zinc	41,45	dZIP89B	11,18	zinc	dZIP89B	MESH:D015032	41975(Tax:7227)	Chemical	Gene	uptake|compound|START_ENTITY END_ENTITY|nmod|uptake	A role for dZIP89B in Drosophila dietary zinc uptake reveals additional complexity in the zinc absorption process .
26545796	0	zinc	90,94	dZIP89B	11,18	zinc	dZIP89B	MESH:D015032	41975(Tax:7227)	Chemical	Gene	process|compound|START_ENTITY complexity|nmod|process reveals|dobj|complexity reveals|nsubj|role role|nmod|END_ENTITY	A role for dZIP89B in Drosophila dietary zinc uptake reveals additional complexity in the zinc absorption process .
523952	0	zinc	15,19	delta-aminolaevulinic_acid_dehydratase	30,68	zinc	delta-aminolaevulinic acid dehydratase	MESH:D015032	210	Chemical	Gene	intake|compound|START_ENTITY intake|nmod|END_ENTITY	Effect of oral zinc intake on delta-aminolaevulinic_acid_dehydratase in red blood cells .
7904558	0	zinc	57,61	delta_EF1	42,51	zinc	delta EF1	MESH:D015032	396029(Tax:9031)	Chemical	Gene	protein|compound|START_ENTITY protein|nsubj|END_ENTITY	Delta-crystallin_enhancer_binding_protein delta_EF1 is a zinc finger-homeodomain protein implicated in postgastrulation embryogenesis .
23436987	0	zinc	41,45	dopamine_transporter	85,105	zinc	dopamine transporter	MESH:D015032	6531	Chemical	Gene	site|compound|START_ENTITY analysis|nmod|site validates|nsubj|analysis validates|dobj|model model|compound|END_ENTITY	Mutational analysis of the high-affinity zinc binding site validates a refined human dopamine_transporter homology model .
1792694	0	zinc	47,51	epidermal_growth_factor	14,37	zinc	epidermal growth factor	MESH:D015032	13645(Tax:10090)	Chemical	Gene	levels|compound|START_ENTITY effect|nmod|levels effect|nmod|END_ENTITY	The effect of epidermal_growth_factor on serum zinc levels .
21900236	0	zinc	8,12	epidermal_growth_factor	42,65	zinc	epidermal growth factor	MESH:D015032	1950	Chemical	Gene	metallothionein-3|compound|START_ENTITY metallothionein-3|nmod|END_ENTITY	Role of zinc metallothionein-3 -LRB- ZnMt3 -RRB- in epidermal_growth_factor -LRB- EGF -RRB- - induced c-Abl protein activation and actin polymerization in cultured astrocytes .
8430225	0	zinc	44,48	epidermal_growth_factor	11,34	zinc	epidermal growth factor	MESH:D015032	13645(Tax:10090)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of epidermal_growth_factor on serum zinc and plasma prostaglandin_E2 levels of mice with pressure sores .
16246571	0	zinc	74,78	estrogen_receptor	90,107	zinc	estrogen receptor	MESH:D015032	2099	Chemical	Gene	fingers|compound|START_ENTITY fingers|nmod|END_ENTITY	Reactivity of zinc finger cysteines : chemical modifications within labile zinc fingers in estrogen_receptor .
8635592	0	zinc	75,79	estrogen_receptor	57,74	zinc	estrogen receptor	MESH:D015032	2099	Chemical	Gene	finger|compound|START_ENTITY finger|compound|END_ENTITY	Reversible zinc exchange between metallothionein and the estrogen_receptor zinc finger .
6196359	0	zinc	40,44	factor_A	22,30	zinc	factor A	MESH:D015032	397777(Tax:8355)	Chemical	Gene	requires|dobj|START_ENTITY requires|nsubj|END_ENTITY	Xenopus transcription factor_A requires zinc for binding to the 5 S RNA gene .
15234987	0	zinc	10,14	friend_of_GATA	27,41	zinc	friend of GATA	MESH:D015032	161882	Chemical	Gene	finger|compound|START_ENTITY finger|nmod|END_ENTITY	A classic zinc finger from friend_of_GATA mediates an interaction with the coiled-coil of transforming acidic coiled-coil 3 .
26404630	0	zinc	14,18	gastrin	32,39	zinc	gastrin	MESH:D015032	2520	Chemical	Gene	START_ENTITY|nmod|promoter promoter|compound|END_ENTITY	Activation by zinc of the human gastrin gene promoter in colon_cancer cells in vitro and in vivo .
9169852	0	zinc	47,51	gfi-1	74,79	zinc	gfi-1	MESH:D015032	2672	Chemical	Gene	finger|compound|START_ENTITY finger|amod|END_ENTITY	The C. _ elegans gene pag-3 is homologous to the zinc finger proto-oncogene gfi-1 .
8364225	0	zinc	7,11	gli	0,3	zinc	gli	MESH:D015032	34927(Tax:7227)	Chemical	Gene	factor|compound|START_ENTITY END_ENTITY|appos|factor	gli , a zinc finger transcription factor and oncogene , is expressed during normal mouse development .
15614761	0	zinc	32,36	gli2b	50,55	zinc	gli2b	MESH:D015032	548610(Tax:7955)	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Expression of a novel zebrafish zinc finger gene , gli2b , is affected in Hedgehog and Notch signaling related mutants during embryonic development .
2064996	0	zinc	38,42	granulocyte-macrophage_colony-stimulating_factor	73,121	zinc	granulocyte-macrophage colony-stimulating factor	MESH:D015032	1437	Chemical	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Posttranscriptional regulation of the zinc finger-encoding EGR-1 gene by granulocyte-macrophage_colony-stimulating_factor in human U-937 monocytic_leukemia cells : involvement of a pertussis toxin-sensitive G protein .
10720163	0	zinc	13,17	growth_hormone	41,55	zinc	growth hormone	MESH:D015032	81668(Tax:10116)	Chemical	Gene	Chelation|nmod|START_ENTITY amplifies|nsubj|Chelation amplifies|dobj|induction induction|nmod|levels levels|amod|END_ENTITY	Chelation of zinc amplifies induction of growth_hormone mRNA levels in cultured rat pituitary tumor cells .
23182824	0	zinc	58,62	growth_hormone	91,105	zinc	growth hormone	MESH:D015032	2688	Chemical	Gene	role|nmod|START_ENTITY role|nmod|pathway pathway|nmod|END_ENTITY	From endoplasmic reticulum to secretory granules : role of zinc in the secretory pathway of growth_hormone .
23224626	0	zinc	19,23	growth_hormone	117,131	zinc	growth hormone	MESH:D015032	2688	Chemical	Gene	supplementation|compound|START_ENTITY effect|nmod|supplementation treated|nsubj|effect treated|nmod|END_ENTITY	Enhanced effect of zinc and calcium supplementation on bone status in growth_hormone-deficient_children treated with growth_hormone : a pilot randomized controlled trial .
23970781	0	zinc	10,14	growth_hormone	35,49	zinc	growth hormone	MESH:D015032	81668(Tax:10116)	Chemical	Gene	residues|compound|START_ENTITY Effect|nmod|residues Effect|nmod|END_ENTITY	Effect of zinc binding residues in growth_hormone -LRB- GH -RRB- and altered intracellular zinc content on regulated GH secretion .
24259161	0	zinc	13,17	growth_hormone	53,67	zinc	growth hormone	MESH:D015032	81668(Tax:10116)	Chemical	Gene	depletion|compound|START_ENTITY Influence|nmod|depletion END_ENTITY|nsubj|Influence	Influence of zinc depletion and zinc status on serum growth_hormone levels in rats .
24296719	0	zinc	12,16	growth_hormone	29,43	zinc	growth hormone	MESH:D015032	2688	Chemical	Gene	dynamics|compound|START_ENTITY role|nmod|dynamics role|nmod|secretion secretion|amod|END_ENTITY	The role of zinc dynamics in growth_hormone secretion .
25196974	0	zinc	28,32	growth_hormone	98,112	zinc	growth hormone	MESH:D015032	81668(Tax:10116)	Chemical	Gene	import|compound|START_ENTITY Alteration|nmod|import affects|nsubj|Alteration affects|dobj|secretion secretion|nmod|END_ENTITY	Alteration of ZnT5-mediated zinc import into the early secretory pathway affects the secretion of growth_hormone from rat pituitary cells .
27004850	0	zinc	51,55	growth_hormone	21,35	zinc	growth hormone	MESH:D015032	2688	Chemical	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	Amyloid formation of growth_hormone in presence of zinc : Relevance to its storage in secretory granules .
3004494	0	zinc	10,14	growth_hormone	44,58	zinc	growth hormone	MESH:D015032	81668(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of zinc on the binding and action of growth_hormone in isolated rat adipocytes .
3179576	0	zinc	41,45	growth_hormone	23,37	zinc	growth hormone	MESH:D015032	2688	Chemical	Gene	metabolism|compound|START_ENTITY effects|nmod|metabolism effects|nmod|END_ENTITY	Acute effects of human growth_hormone on zinc , copper , calcium and magnesium metabolism in normal subjects .
8243307	0	zinc	45,49	growth_hormone	15,29	zinc	growth hormone	MESH:D015032	2688	Chemical	Gene	bioactivity|nmod|START_ENTITY bioactivity|nsubj|Enhancement Enhancement|nmod|END_ENTITY	Enhancement of growth_hormone bioactivity by zinc in the eluted stain assay system .
8370519	0	zinc	26,30	growth_hormone	103,117	zinc	growth hormone	MESH:D015032	14599(Tax:10090)	Chemical	Gene	protein|compound|START_ENTITY Identification|nmod|protein binding|nsubj|Identification binding|xcomp|critical critical|nmod|expression expression|amod|END_ENTITY	Identification of a novel zinc finger protein binding a conserved element critical for Pit-1-dependent growth_hormone gene expression .
10438528	0	zinc	16,20	hFOG-2	0,6	zinc	hFOG-2	MESH:D015032	23414	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	hFOG-2 , a novel zinc finger protein , binds the co-repressor mCtBP2 and modulates GATA-mediated activation .
16153295	0	zinc	6,10	hZIP1	0,5	zinc	hZIP1	MESH:D015032	27173	Chemical	Gene	uptake|compound|START_ENTITY uptake|amod|END_ENTITY	hZIP1 zinc uptake transporter down regulation and zinc depletion in prostate_cancer .
18765529	0	zinc	22,26	hZIP1	46,51	zinc	hZIP1	MESH:D015032	27173	Chemical	Gene	Overexpression|nmod|START_ENTITY uptake|nsubj|Overexpression uptake|ccomp|inhibits inhibits|nsubj|END_ENTITY	Overexpression of the zinc uptake transporter hZIP1 inhibits nuclear factor-kappaB and reduces the malignant potential of prostate_cancer cells in vitro and in vivo .
20705137	0	zinc	13,17	hZIP1	75,80	zinc	hZIP1	MESH:D015032	27173	Chemical	Gene	accumulation|compound|START_ENTITY accumulation|nmod|END_ENTITY	Differential zinc accumulation and expression of human zinc transporter 1 -LRB- hZIP1 -RRB- in prostate glands .
21360563	0	zinc	6,10	hZIP1	0,5	zinc	hZIP1	MESH:D015032	27173	Chemical	Gene	down-regulation|compound|START_ENTITY down-regulation|amod|END_ENTITY	hZIP1 zinc transporter down-regulation in prostate_cancer involves the overexpression of ras_responsive_element_binding_protein-1 -LRB- RREB-1 -RRB- .
10681536	0	zinc	41,45	hZIP2	35,40	zinc	hZIP2	MESH:D015032	29986	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	Functional expression of the human hZIP2 zinc transporter .
17202136	0	zinc	82,86	hZIP4	100,105	zinc	hZIP4	MESH:D015032	55630	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	A histidine-rich cluster mediates the ubiquitination and degradation of the human zinc transporter , hZIP4 , and protects against zinc cytotoxicity .
25882556	0	zinc	69,73	hZIP4	32,37	zinc	hZIP4	MESH:D015032	55630	Chemical	Gene	domain|compound|START_ENTITY domain|nsubj|loop loop|nmod|END_ENTITY	The large intracellular loop of hZIP4 is an intrinsically disordered zinc binding domain .
25882556	0	zinc	69,73	hZIP4	32,37	zinc	hZIP4	MESH:D015032	55630	Chemical	Gene	domain|compound|START_ENTITY domain|nsubj|loop loop|nmod|END_ENTITY	The large intracellular loop of hZIP4 is an intrinsically disordered zinc binding domain .
11937503	0	zinc	29,33	hZTL1	47,52	zinc	hZTL1	MESH:D015032	64924	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	A novel zinc-regulated human zinc transporter , hZTL1 , is localized to the enterocyte apical membrane .
16844077	0	zinc	100,104	hZip1	77,82	zinc	hZip1	MESH:D015032	27173	Chemical	Gene	transport|compound|START_ENTITY required|nmod|transport required|nsubjpass|residues residues|nmod|region region|nmod|END_ENTITY	Histidine residues in the region between transmembrane domains III and IV of hZip1 are required for zinc transport across the plasma membrane in PC-3 cells .
19026724	0	zinc	40,44	hZip1	60,65	zinc	hZip1	MESH:D015032	27173	Chemical	Gene	regulation|nmod|START_ENTITY uptake|nsubj|regulation uptake|dobj|END_ENTITY	Transcriptional regulation of the major zinc uptake protein hZip1 in prostate_cancer cells .
23378263	0	zinc	27,31	hZip1	0,5	zinc	hZip1	MESH:D015032	27173	Chemical	Gene	homoeostasis|compound|START_ENTITY regulates|dobj|homoeostasis regulates|nsubj|END_ENTITY	hZip1 -LRB- hSLC39A1 -RRB- regulates zinc homoeostasis in gut epithelial cells .
17550612	0	zinc	16,20	hZip2	0,5	zinc	hZip2	MESH:D015032	29986	Chemical	Gene	transporters|compound|START_ENTITY transporters|compound|END_ENTITY	hZip2 and hZip3 zinc transporters are down regulated in human prostate adenocarcinomatous glands .
11988082	0	zinc	33,37	hZnT4	27,32	zinc	hZnT4	MESH:D015032	7782	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	Constitutive expression of hZnT4 zinc transporter in human breast epithelial cells .
12743795	0	zinc	111,115	hZnT4	30,35	zinc	hZnT4	MESH:D015032	7782	Chemical	Gene	secretion|compound|START_ENTITY leading|nmod|secretion mammary_gland_disorder|acl|leading expression|nmod|mammary_gland_disorder Analysis|appos|expression Analysis|appos|Slc30A4 Slc30A4|amod|END_ENTITY	Analysis of zinc transporter , hZnT4 -LRB- Slc30A4 -RRB- , gene expression in a mammary_gland_disorder leading to reduced zinc secretion into milk .
12743795	0	zinc	12,16	hZnT4	30,35	zinc	hZnT4	MESH:D015032	7782	Chemical	Gene	transporter|compound|START_ENTITY Analysis|nmod|transporter Analysis|appos|Slc30A4 Slc30A4|amod|END_ENTITY	Analysis of zinc transporter , hZnT4 -LRB- Slc30A4 -RRB- , gene expression in a mammary_gland_disorder leading to reduced zinc secretion into milk .
15930159	0	zinc	71,75	helicase	111,119	zinc	helicase	MESH:D015032	164045	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Structural and functional characterizations reveal the importance of a zinc binding domain in Bloom 's _ syndrome helicase .
10849834	0	zinc	36,40	insulin	25,32	zinc	insulin	MESH:D015032	3630	Chemical	Gene	suspension|compound|START_ENTITY Effect|nmod|suspension Effect|nmod|END_ENTITY	Effect of shear on human insulin in zinc suspension .
1297601	0	zinc	50,54	insulin	96,103	zinc	insulin	MESH:D015032	3630	Chemical	Gene	insulin|compound|START_ENTITY insulin|nmod|END_ENTITY	-LSB- Action profile of a semisynthetic human isophane zinc insulin compared with customary isophane insulin -RSB- .
13118768	0	zinc	20,24	insulin	12,19	zinc	insulin	MESH:D015032	3630	Chemical	Gene	mixtures|compound|START_ENTITY END_ENTITY|dep|mixtures	Prescribing insulin zinc suspension mixtures .
13375857	0	zinc	20,24	insulin	25,32	zinc	insulin	MESH:D015032	3630	Chemical	Gene	suspensions|compound|START_ENTITY suspensions|compound|END_ENTITY	-LSB- Therapeutic use of zinc insulin suspensions -RSB- .
15640877	0	zinc	9,13	insulin	17,24	zinc	insulin	MESH:D015032	3630	Chemical	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	-LSB- Role of zinc in insulin resistance -RSB- .
16984975	0	zinc	58,62	insulin	99,106	zinc	insulin	MESH:D015032	3630	Chemical	Gene	transporter|compound|START_ENTITY characterization|nmod|transporter ZnT8|nsubj|characterization ZnT8|nmod|secretion secretion|compound|END_ENTITY	In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion .
17143514	0	zinc	41,45	insulin	149,156	zinc	insulin	MESH:D015032	3630	Chemical	Gene	insulin-degrading_enzyme|compound|START_ENTITY demonstration|nmod|insulin-degrading_enzyme demonstration|dep|correlation correlation|nmod|levels levels|compound|END_ENTITY	Immunohistochemical demonstration of the zinc metalloprotease insulin-degrading_enzyme in normal and malignant human breast : correlation with tissue insulin levels .
17205988	0	zinc	9,13	insulin	51,58	zinc	insulin	MESH:D015032	3630	Chemical	Gene	parameters|compound|START_ENTITY parameters|nmod|relation relation|nmod|END_ENTITY	Selected zinc metabolism parameters in relation to insulin , renin-angiotensin-aldosterone system , and blood pressure in healthy subjects : gender differences .
18800198	0	zinc	24,28	insulin	39,46	zinc	insulin	MESH:D015032	3630	Chemical	Gene	status|compound|START_ENTITY status|nmod|END_ENTITY	Effect of sub-deficient zinc status on insulin sensitivity after burn_injury in rats .
19234324	0	zinc	57,61	insulin	49,56	zinc	insulin	MESH:D015032	483665(Tax:9615)	Chemical	Gene	suspension|compound|START_ENTITY suspension|compound|END_ENTITY	Pharmacokinetics and pharmacodynamics of porcine insulin zinc suspension in eight diabetic dogs .
19463741	0	zinc	70,74	insulin	102,109	zinc	insulin	MESH:D015032	3630	Chemical	Gene	chelation|compound|START_ENTITY chelation|nmod|oligomers oligomers|compound|END_ENTITY	Ability of GHTD-amide and analogs to enhance insulin activity through zinc chelation and dispersal of insulin oligomers .
19463741	0	zinc	70,74	insulin	45,52	zinc	insulin	MESH:D015032	3630	Chemical	Gene	chelation|compound|START_ENTITY enhance|nmod|chelation enhance|dobj|activity activity|compound|END_ENTITY	Ability of GHTD-amide and analogs to enhance insulin activity through zinc chelation and dispersal of insulin oligomers .
19733567	0	zinc	14,18	insulin	57,64	zinc	insulin	MESH:D015032	3630	Chemical	Gene	protein|compound|START_ENTITY reveals|nsubj|protein reveals|dobj|role role|nmod|VNTR VNTR|compound|END_ENTITY	An engineered zinc finger protein reveals a role for the insulin VNTR in the regulation of the insulin and adjacent IGF2 genes .
19733567	0	zinc	14,18	insulin	95,102	zinc	insulin	MESH:D015032	3630	Chemical	Gene	protein|compound|START_ENTITY reveals|nsubj|protein reveals|dobj|role role|nmod|VNTR VNTR|nmod|regulation regulation|nmod|END_ENTITY	An engineered zinc finger protein reveals a role for the insulin VNTR in the regulation of the insulin and adjacent IGF2 genes .
21028969	0	zinc	10,14	insulin	45,52	zinc	insulin	MESH:D015032	3630	Chemical	Gene	Effect|nmod|START_ENTITY supplementation|nsubj|Effect supplementation|nmod|markers markers|nmod|resistance resistance|compound|END_ENTITY	Effect of zinc supplementation on markers of insulin resistance , oxidative stress , and inflammation among prepubescent children with metabolic_syndrome .
21099294	0	zinc	26,30	insulin	49,56	zinc	insulin	MESH:D015032	3630	Chemical	Gene	START_ENTITY|nmod|control control|nmod|secretion secretion|compound|END_ENTITY	Think zinc : New roles for zinc in the control of insulin secretion .
21099294	0	zinc	6,10	insulin	49,56	zinc	insulin	MESH:D015032	3630	Chemical	Gene	START_ENTITY|dep|roles roles|nmod|zinc zinc|nmod|control control|nmod|secretion secretion|compound|END_ENTITY	Think zinc : New roles for zinc in the control of insulin secretion .
22059434	0	zinc	67,71	insulin	48,55	zinc	insulin	MESH:D015032	3630	Chemical	Gene	effect|nmod|START_ENTITY Multimerization|dep|effect Multimerization|nmod|END_ENTITY	Multimerization and aggregation of native-state insulin : effect of zinc .
22211582	0	zinc	22,26	insulin	45,52	zinc	insulin	MESH:D015032	3630	Chemical	Gene	Efficacy|nmod|START_ENTITY recombinant|nsubj|Efficacy recombinant|dobj|END_ENTITY	Efficacy of protamine zinc recombinant human insulin for controlling hyperglycemia in dogs with diabetes_mellitus .
22277170	0	zinc	5,9	insulin	54,61	zinc	insulin	MESH:D015032	3630	Chemical	Gene	status|compound|START_ENTITY associated|nsubjpass|status associated|nmod|risk risk|nmod|resistance resistance|compound|END_ENTITY	Poor zinc status is associated with increased risk of insulin resistance in Spanish children .
22920799	0	zinc	63,67	insulin	44,51	zinc	insulin	MESH:D015032	3630	Chemical	Gene	chelation|compound|START_ENTITY induced|nmod|chelation END_ENTITY|acl|induced	Ultra-rapid absorption of recombinant human insulin induced by zinc chelation and surface charge masking .
24943234	0	zinc	6,10	insulin	54,61	zinc	insulin	MESH:D015032	3630	Chemical	Gene	concentration|compound|START_ENTITY associated|nsubj|concentration associated|nmod|resistance resistance|compound|END_ENTITY	Serum zinc concentration is inversely associated with insulin resistance but not related with metabolic_syndrome in nondiabetic Korean adults .
25348609	0	zinc	10,14	insulin	34,41	zinc	insulin	MESH:D015032	3630	Chemical	Gene	supplementation|compound|START_ENTITY supplementation|nmod|secretion secretion|compound|END_ENTITY	Effect of zinc supplementation on insulin secretion : interaction between zinc and SLC30A8 genotype in Old Order Amish .
25348609	0	zinc	73,77	insulin	34,41	zinc	insulin	MESH:D015032	3630	Chemical	Gene	genotype|compound|START_ENTITY interaction|nmod|genotype Effect|dep|interaction Effect|nmod|supplementation supplementation|nmod|secretion secretion|compound|END_ENTITY	Effect of zinc supplementation on insulin secretion : interaction between zinc and SLC30A8 genotype in Old Order Amish .
25905055	0	zinc	10,14	insulin	34,41	zinc	insulin	MESH:D015032	3630	Chemical	Gene	supplementation|compound|START_ENTITY supplementation|nmod|resistance resistance|compound|END_ENTITY	Effect of zinc supplementation on insulin resistance , energy and macronutrients intakes in pregnant women with impaired_glucose_tolerance .
26386292	0	zinc	12,16	insulin	60,67	zinc	insulin	MESH:D015032	3630	Chemical	Gene	delivery|compound|START_ENTITY delivery|nmod|nerves nerves|nmod|phase phase|compound|END_ENTITY	Position on zinc delivery to olfactory nerves in intranasal insulin phase I-III clinical trials .
2648613	0	zinc	22,26	insulin	51,58	zinc	insulin	MESH:D015032	3630	Chemical	Gene	reaction|nmod|START_ENTITY reaction|dep|complication complication|nmod|treatment treatment|compound|END_ENTITY	Cutaneous reaction to zinc -- a rare complication of insulin treatment .
7004863	0	zinc	20,24	insulin	28,35	zinc	insulin	MESH:D015032	3630	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of exogenous zinc on insulin secretion in vitro .
7021128	0	zinc	48,52	insulin	8,15	zinc	insulin	MESH:D015032	100009181(Tax:9986)	Chemical	Gene	blocking|nmod|START_ENTITY insufficiency|advcl|blocking insufficiency|nsubj|END_ENTITY	Primary insulin insufficiency after blocking of zinc in pancreatic beta-cells .
83864	0	zinc	11,15	insulin	69,76	zinc	insulin	MESH:D015032	3630	Chemical	Gene	Effects|nmod|START_ENTITY ion|nsubj|Effects ion|nmod|END_ENTITY	Effects of zinc ion on the conformation of antigenic determinants on insulin .
9853535	0	zinc	8,12	insulin	97,104	zinc	insulin	MESH:D015032	3630	Chemical	Gene	intake|compound|START_ENTITY associated|nsubj|intake associated|nmod|resistance resistance|compound|END_ENTITY	Current zinc intake and risk of diabetes and coronary_artery_disease and factors associated with insulin resistance in rural and urban populations of North India .
15477998	0	zinc	100,104	insulin-like_growth_factor-I	119,147	zinc	insulin-like growth factor-I	MESH:D015032	16000(Tax:10090)	Chemical	Gene	modulation|compound|START_ENTITY modulation|nmod|effect effect|nmod:poss|END_ENTITY	Role of zinc in regulation of protein tyrosine phosphatase activity in osteoblastic MC3T3-E1 cells : zinc modulation of insulin-like_growth_factor-I 's effect .
15477998	0	zinc	8,12	insulin-like_growth_factor-I	119,147	zinc	insulin-like growth factor-I	MESH:D015032	16000(Tax:10090)	Chemical	Gene	Role|nmod|START_ENTITY Role|dep|modulation modulation|nmod|effect effect|nmod:poss|END_ENTITY	Role of zinc in regulation of protein tyrosine phosphatase activity in osteoblastic MC3T3-E1 cells : zinc modulation of insulin-like_growth_factor-I 's effect .
22683053	0	zinc	10,14	leptin	31,37	zinc	leptin	MESH:D015032	25608(Tax:10116)	Chemical	Gene	induces|nsubj|START_ENTITY induces|dobj|resistance resistance|compound|END_ENTITY	Excessive zinc in diet induces leptin resistance in Wistar rat through increased uptake of nutrients at intestinal level .
25434301	0	zinc	6,10	leptin	37,43	zinc	leptin	MESH:D015032	3952	Chemical	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	Serum zinc is associated with plasma leptin and Cu-Zn SOD in elite male basketball athletes .
1932096	0	zinc	46,50	leukotriene_A4_hydrolase	18,42	zinc	leukotriene A4 hydrolase	MESH:D015032	16993(Tax:10090)	Chemical	Gene	metalloenzyme|compound|START_ENTITY END_ENTITY|dep|metalloenzyme	Recombinant mouse leukotriene_A4_hydrolase : a zinc metalloenzyme with dual enzymatic activities .
26662428	0	zinc	6,10	leukotriene_A4_hydrolase	101,125	zinc	leukotriene A4 hydrolase	MESH:D015032	4048	Chemical	Gene	gene|compound|START_ENTITY related|nsubjpass|gene related|nmod|END_ENTITY	Novel zinc protease gene isolated from Dictyostelium_discoideum is structurally related to mammalian leukotriene_A4_hydrolase .
11133983	0	zinc	32,36	mGluR1	89,95	zinc	mGluR1	MESH:D015032	14799(Tax:10090)	Chemical	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Construction of a high affinity zinc binding site in the metabotropic glutamate receptor mGluR1 : noncompetitive antagonism originating from the amino-terminal domain of a family C G-protein-coupled receptor .
2108027	0	zinc	48,52	mKr2	42,46	zinc	mKr2	MESH:D015032	22678(Tax:10090)	Chemical	Gene	finger|compound|START_ENTITY finger|amod|END_ENTITY	NMR and molecular dynamics studies of the mKr2 ` zinc finger ' .
14612438	0	zinc	41,45	mZIP4	35,40	zinc	mZIP4	MESH:D015032	72027(Tax:10090)	Chemical	Gene	transporter|compound|START_ENTITY transporter|amod|END_ENTITY	Zn2 + - stimulated endocytosis of the mZIP4 zinc transporter regulates its location at the plasma membrane .
7775392	0	zinc	75,79	macrophage_metalloelastase	6,32	zinc	macrophage metalloelastase	MESH:D015032	17381(Tax:10090)	Chemical	Gene	requires|dobj|START_ENTITY requires|nsubj|END_ENTITY	Mouse macrophage_metalloelastase expressed in bacteria absolutely requires zinc for activity .
15169922	0	zinc	65,69	macrophage_migration_inhibitory_factor	13,51	zinc	macrophage migration inhibitory factor	MESH:D015032	103694877	Chemical	Gene	content|compound|START_ENTITY END_ENTITY|nmod|content	Influence of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- on the zinc content and redox state of protein-bound sulphydryl groups in rat sperm : indications for a new role of MIF in sperm maturation .
12764133	0	zinc	22,26	metal-response_element-binding_transcription_factor-1	38,91	zinc	metal-response element-binding transcription factor-1	MESH:D015032	17764(Tax:10090)	Chemical	Gene	fingers|compound|START_ENTITY fingers|nmod|END_ENTITY	Putative zinc-sensing zinc fingers of metal-response_element-binding_transcription_factor-1 stabilize a metal-dependent chromatin complex on the endogenous metallothionein-I promoter .
16055450	0	zinc	8,12	metal-responsive_element_binding_transcription_factor-1	24,79	zinc	metal-responsive element binding transcription factor-1	MESH:D015032	4520	Chemical	Gene	fingers|compound|START_ENTITY fingers|nmod|END_ENTITY	The six zinc fingers of metal-responsive_element_binding_transcription_factor-1 form stable and quasi-ordered structures with relatively small differences in zinc affinities .
10958790	0	zinc	32,36	metal_response_element-binding_transcription_factor-1	74,127	zinc	metal response element-binding transcription factor-1	MESH:D015032	17764(Tax:10090)	Chemical	Gene	fingers|compound|START_ENTITY fingers|nmod|END_ENTITY	Functional heterogeneity in the zinc fingers of metalloregulatory protein metal_response_element-binding_transcription_factor-1 .
2036213	0	zinc	47,51	metalloprotease	52,67	zinc	metalloprotease	MESH:D015032	9538251	Chemical	Gene	identification|nmod|START_ENTITY END_ENTITY|nsubj|identification	Rapid identification of Legionella_pneumophila zinc metalloprotease using chromogenic detection .
6470825	0	zinc	65,69	metallothionein-I	22,39	zinc	metallothionein-I	MESH:D015032	24567(Tax:10116)	Chemical	Gene	status|compound|START_ENTITY assessment|nmod|status END_ENTITY|nmod|assessment	Measurement of plasma metallothionein-I in the assessment of the zinc status of zinc-deficient and stressed rats .
3309208	0	zinc	30,34	metallothionein_I	98,115	zinc	metallothionein I	MESH:D015032	24567(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|concentrations concentrations|amod|END_ENTITY	Effects of changes in dietary zinc , copper and selenium supply and of endotoxin administration on metallothionein_I concentrations in blood cells and urine in the rat .
3655938	0	zinc	19,23	metallothionein_I	51,68	zinc	metallothionein I	MESH:D015032	24567(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY supply|nsubj|Effect supply|nmod|concentrations concentrations|compound|END_ENTITY	Effect of maternal zinc supply on blood and tissue metallothionein_I concentrations in suckling rats .
8065534	0	zinc	16,20	metallothionein_I	21,38	zinc	metallothionein I	MESH:D015032	24567(Tax:10116)	Chemical	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	Distribution of zinc metallothionein_I mRNA in rat brain using in situ hybridization .
7862096	0	zinc	18,22	methionine_aminopeptidase	38,63	zinc	methionine aminopeptidase	MESH:D015032	850945(Tax:4932)	Chemical	Gene	fingers|compound|START_ENTITY fingers|nmod|END_ENTITY	Evidence that two zinc fingers in the methionine_aminopeptidase from Saccharomyces_cerevisiae are important for normal growth .
11498945	0	zinc	19,23	microtubule-associated_protein_2	27,59	zinc	microtubule-associated protein 2	MESH:D015032	17756(Tax:10090)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effect of dietary zinc on microtubule-associated_protein_2 expression in the brain of mice -RSB- .
3404289	0	zinc	30,34	milk	10,14	zinc	milk	MESH:D015032	100532204	Chemical	Gene	absorption|compound|START_ENTITY Effect|nmod|absorption Effect|nmod|END_ENTITY	Effect of milk and lactose on zinc absorption in lactose-intolerant postmenopausal women .
24097990	0	zinc	77,81	myelin_transcription_factor_1	40,69	zinc	myelin transcription factor 1	MESH:D015032	4661	Chemical	Gene	fingers|compound|START_ENTITY fingers|amod|END_ENTITY	A structural analysis of DNA binding by myelin_transcription_factor_1 double zinc fingers .
9210873	0	zinc	102,106	myelin_transcription_factor_1	62,91	zinc	myelin transcription factor 1	MESH:D015032	4661	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	High-grade human brain_tumors exhibit increased expression of myelin_transcription_factor_1 -LRB- MYT1 -RRB- , a zinc finger DNA-binding protein .
10606515	0	zinc	102,106	neural_zinc_finger_factor_1	61,88	zinc	neural zinc finger factor 1	MESH:D015032	23040	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	Metal and DNA binding properties of a two-domain fragment of neural_zinc_finger_factor_1 , a CCHC-type zinc binding protein .
11404087	0	zinc	44,48	noz1	26,30	zinc	noz1	MESH:D015032	114429(Tax:7955)	Chemical	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	Cloning and expression of noz1 , a zebrafish zinc finger gene related to Drosophila nocA .
8288124	0	zinc	14,18	odd-paired	0,10	zinc	odd-paired	MESH:D015032	40605(Tax:7227)	Chemical	Gene	protein|compound|START_ENTITY END_ENTITY|dep|protein	odd-paired : a zinc finger pair-rule protein required for the timely activation of engrailed and wingless in Drosophila embryos .
8019156	0	zinc	11,15	ornithine_transcarbamylase	27,53	zinc	ornithine transcarbamylase	MESH:D015032	25611(Tax:10116)	Chemical	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|compound|END_ENTITY	Effects of zinc on hepatic ornithine_transcarbamylase -LRB- OTC -RRB- activity .
18081865	0	zinc	34,38	p21_cip1	8,16	zinc	p21 cip1	MESH:D015032	1026	Chemical	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	Ciz1 , a p21_cip1 / Waf1-interacting zinc finger protein and DNA replication factor , is a novel molecular partner for human enhancer of rudimentary homolog .
10867037	0	zinc	90,94	p53	18,21	zinc	p53	MESH:D015032	7157	Chemical	Gene	depletion|nmod|START_ENTITY up-regulated|nmod|depletion up-regulated|nsubjpass|Expression Expression|nmod|gene gene|compound|END_ENTITY	Expression of the p53 tumor suppressor gene is up-regulated by depletion of intracellular zinc in HepG2 cells .
11077439	0	zinc	55,59	p53	89,92	zinc	p53	MESH:D015032	7157	Chemical	Gene	Metalloregulation|nmod|START_ENTITY mediates|nsubj|Metalloregulation mediates|dobj|renaturation renaturation|nmod|END_ENTITY	Metalloregulation of the tumor suppressor protein p53 : zinc mediates the renaturation of p53 after exposure to metal chelators in vitro and in intact cells .
12107073	0	zinc	70,74	p53	0,3	zinc	p53	MESH:D015032	7157	Chemical	Gene	status|compound|START_ENTITY altered|nmod|status altered|nsubjpass|protein protein|nummod|END_ENTITY	p53 protein and p21 mRNA levels and caspase-3 activity are altered by zinc status in aortic endothelial cells .
15566940	0	zinc	47,51	p53	27,30	zinc	p53	MESH:D015032	7157	Chemical	Gene	chimeras|compound|START_ENTITY target|nmod|chimeras target|nsubj|transcription transcription|nmod|END_ENTITY	Selective transcription of p53 target genes by zinc finger-p53 DNA binding domain chimeras .
17910948	0	zinc	16,20	p53	44,47	zinc	p53	MESH:D015032	7157	Chemical	Gene	gene|compound|START_ENTITY suppresses|nsubj|gene suppresses|dobj|END_ENTITY	ZNF307 , a novel zinc finger gene suppresses p53 and p21 pathway .
18296737	0	zinc	102,106	p53	87,90	zinc	p53	MESH:D015032	7157	Chemical	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	Suppression of Gadd45 alleviates the G2/M blockage and the enhanced phosphorylation of p53 and p38 in zinc supplemented normal human bronchial epithelial cells .
18951928	0	zinc	14,18	p53	37,40	zinc	p53	MESH:D015032	7157	Chemical	Gene	increase|compound|START_ENTITY inhibits|nsubj|increase inhibits|dobj|END_ENTITY	Intracellular zinc increase inhibits p53 -LRB- - / - -RRB- pancreatic adenocarcinoma cell growth by ROS/AIF-mediated apoptosis .
19001415	0	zinc	19,23	p53	52,55	zinc	p53	MESH:D015032	22060(Tax:10090)	Chemical	Gene	finger|compound|START_ENTITY interacts|nsubj|finger interacts|nmod|END_ENTITY	Monocytic_leukemia zinc finger -LRB- MOZ -RRB- interacts with p53 to induce p21 expression and cell-cycle arrest .
21072344	0	zinc	12,16	p53	18,21	zinc	p53	MESH:D015032	7157	Chemical	Gene	START_ENTITY|dep|misfolding misfolding|compound|END_ENTITY	The missing zinc : p53 misfolding and cancer .
21508668	0	zinc	37,41	p53	10,13	zinc	p53	MESH:D015032	7157	Chemical	Gene	Restoring|nmod|START_ENTITY Restoring|dobj|conformation conformation|nummod|END_ENTITY	Restoring p53 active conformation by zinc increases the response of mutant p53 tumor cells to anticancer drugs .
21508668	0	zinc	37,41	p53	75,78	zinc	p53	MESH:D015032	7157	Chemical	Gene	Restoring|nmod|START_ENTITY increases|csubj|Restoring increases|dobj|response response|nmod|cells cells|compound|END_ENTITY	Restoring p53 active conformation by zinc increases the response of mutant p53 tumor cells to anticancer drugs .
21695267	0	zinc	21,25	p53	0,3	zinc	p53	MESH:D015032	7157	Chemical	Gene	nucleases|compound|START_ENTITY repair|nmod|nucleases repair|nummod|END_ENTITY	p53 Gene repair with zinc finger nucleases optimised by yeast 1-hybrid and validated by Solexa sequencing .
23401182	0	zinc	14,18	p53	35,38	zinc	p53	MESH:D015032	7157	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of zinc and the role of p53 in copper-induced cellular stress responses .
25710967	0	zinc	80,84	p53	47,50	zinc	p53	MESH:D015032	7157	Chemical	Gene	transporting|dobj|START_ENTITY rescues|advcl|transporting rescues|dobj|conformation conformation|compound|END_ENTITY	Synthetic metallochaperone ZMC1 rescues mutant p53 conformation by transporting zinc into cells as an ionophore .
26553115	0	zinc	95,99	p53	62,65	zinc	p53	MESH:D015032	7157	Chemical	Gene	transporting|dobj|START_ENTITY rescues|advcl|transporting rescues|dobj|conformation conformation|compound|END_ENTITY	Correction to `` Synthetic metallochaperone ZMC1 rescues mutant p53 conformation by transporting zinc into cells as an ionophore '' .
26976603	0	zinc	88,92	p53	30,33	zinc	p53	MESH:D015032	7157	Chemical	Gene	finger|compound|START_ENTITY domain|nmod|finger domain|compound|END_ENTITY	Recognition of the disordered p53 transactivation domain by the transcriptional adapter zinc finger domains of CREB-binding_protein .
9537652	0	zinc	94,98	p53	14,17	zinc	p53	MESH:D015032	7157	Chemical	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|conformation conformation|compound|END_ENTITY	Modulation of p53 protein conformation and DNA-binding activity by intracellular chelation of zinc .
16304838	0	zinc	41,45	parathyroid_hormone	11,30	zinc	parathyroid hormone	MESH:D015032	24694(Tax:10116)	Chemical	Gene	concentration|compound|START_ENTITY Effects|nmod|concentration Effects|nmod|END_ENTITY	Effects of parathyroid_hormone on plasma zinc concentration in rat with chronic_renal_failure .
16683188	0	zinc	4,8	pmp22	95,100	zinc	pmp22	MESH:D015032	5376	Chemical	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The zinc containing pro-apoptotic protein siva interacts with the peroxisomal membrane protein pmp22 .
8719824	0	zinc	23,27	rKr1	41,45	zinc	rKr1	MESH:D015032	246279(Tax:10116)	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Transcription of a new zinc finger gene , rKr1 , is localized to subtypes of neurons in the adult rat CNS .
8737674	0	zinc	16,20	rKr1	34,38	zinc	rKr1	MESH:D015032	246279(Tax:10116)	Chemical	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A new Cys2/His2 zinc finger gene , rKr1 , expressed in oligodendrocytes and neurons .
9698394	0	zinc	4,8	rapsyn	66,72	zinc	rapsyn	MESH:D015032	362161(Tax:10116)	Chemical	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	The zinc finger domain of the 43-kDa_receptor-associated_protein , _ rapsyn : role in acetylcholine receptor clustering .
10856290	0	zinc	13,17	replication_protein_A	21,42	zinc	replication protein A	MESH:D015032	6117	Chemical	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role for zinc in replication_protein_A .
19222791	0	zinc	33,37	rhodopsin	68,77	zinc	rhodopsin	MESH:D015032	6010	Chemical	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Structural characterization of a zinc high-affinity binding site in rhodopsin .
10893243	0	zinc	170,174	selenocysteine_tRNA_gene_transcription_activating_factor	106,162	zinc	selenocysteine tRNA gene transcription activating factor	MESH:D015032	20841(Tax:10090)	Chemical	Gene	proteins|compound|START_ENTITY proteins|compound|END_ENTITY	Transcriptional regulation of the mouse cytosolic chaperonin subunit gene Ccta/t-complex _ polypeptide_1 by selenocysteine_tRNA_gene_transcription_activating_factor family zinc finger proteins .
16582407	0	zinc	30,34	semenogelin_I	10,23	zinc	semenogelin I	MESH:D015032	6406	Chemical	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Truncated semenogelin_I binds zinc and is cleaved by prostate-specific_antigen .
17425332	0	zinc	10,14	serum_amyloid_A	70,85	zinc	serum amyloid A	MESH:D015032	111345(Tax:10090)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of zinc , copper , and calcium on the structure and stability of serum_amyloid_A .
24029898	0	zinc	4,8	slc30A8	27,34	zinc	slc30A8	MESH:D015032	100155672(Tax:9823)	Chemical	Gene	ZnT8|compound|START_ENTITY ZnT8|appos|END_ENTITY	The zinc transporter ZnT8 -LRB- slc30A8 -RRB- is expressed exclusively in beta cells in porcine islets .
26388512	0	zinc	23,27	slc30A8	46,53	zinc	slc30A8	MESH:D015032	100155672(Tax:9823)	Chemical	Gene	transporter|compound|START_ENTITY Co-localization|nmod|transporter ZnT8|nsubj|Co-localization ZnT8|dobj|END_ENTITY	Co-localization of the zinc transporter ZnT8 -LRB- slc30A8 -RRB- with ghrelin and motilin in the gastrointestinal tract of pigs .
3812671	0	zinc	13,17	somatomedin	29,40	zinc	somatomedin	MESH:D015032	24482(Tax:10116)	Chemical	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of zinc on growth , somatomedin , and glycosaminoglycan metabolism in rats .
12467707	0	zinc	11,15	sp1	31,34	zinc	sp1	MESH:D015032	6667	Chemical	Gene	finger|compound|START_ENTITY finger|dep|END_ENTITY	GFP-linked zinc finger protein sp1 .
12812475	0	zinc	19,23	transcription_factor_IIIA	36,61	zinc	transcription factor IIIA	MESH:D015032	397777(Tax:8355)	Chemical	Gene	finger|compound|START_ENTITY finger|nmod|END_ENTITY	Cobalt-substituted zinc finger 3 of transcription_factor_IIIA : interactions with cognate DNA detected by -LRB- 31 -RRB- P ENDOR spectroscopy .
16405997	0	zinc	56,60	transcription_factor_IIIA	72,97	zinc	transcription factor IIIA	MESH:D015032	2971	Chemical	Gene	fingers|compound|START_ENTITY fingers|nmod|END_ENTITY	Induced fit and `` lock and key '' recognition of 5S RNA by zinc fingers of transcription_factor_IIIA .
8019145	0	zinc	58,62	transcription_factor_IIIA	74,99	zinc	transcription factor IIIA	MESH:D015032	397777(Tax:8355)	Chemical	Gene	fingers|compound|START_ENTITY fingers|nmod|END_ENTITY	1H , 15N and 13C resonance assignments for the first three zinc fingers of transcription_factor_IIIA .
9242690	0	zinc	49,53	transcription_factor_IIIA	65,90	zinc	transcription factor IIIA	MESH:D015032	397777(Tax:8355)	Chemical	Gene	fingers|compound|START_ENTITY fingers|nmod|END_ENTITY	Energetically unfavorable interactions among the zinc fingers of transcription_factor_IIIA when bound to the 5 S rRNA gene .
15102849	0	zinc	81,85	tumor_necrosis_factor-alpha-converting_enzyme	95,140	zinc	tumor necrosis factor-alpha-converting enzyme	MESH:D015032	6868	Chemical	Gene	sites|compound|START_ENTITY sites|nmod|END_ENTITY	Pronounced diversity in electronic and chemical properties between the catalytic zinc sites of tumor_necrosis_factor-alpha-converting_enzyme and matrix metalloproteinases despite their high structural similarity .
9632111	0	zinc	62,66	vitamin_D_receptor	88,106	zinc	vitamin D receptor	MESH:D015032	7421	Chemical	Gene	fingers|compound|START_ENTITY fingers|nmod|END_ENTITY	Novel nuclear localization signal between the two DNA-binding zinc fingers in the human vitamin_D_receptor .
7931345	0	zinc	8,12	zic	29,32	zinc	zic	MESH:D015032	7545	Chemical	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	A novel zinc finger protein , zic , is involved in neurogenesis , especially in the cell lineage of cerebellar granule cells .
11904301	0	zinc	50,54	zinc_transporter_5	68,86	zinc	zinc transporter 5	MESH:D015032	64924	Chemical	Gene	transporter|compound|START_ENTITY transporter|appos|END_ENTITY	Cloning and characterization of a novel mammalian zinc transporter , zinc_transporter_5 , abundantly expressed in pancreatic beta cells .
18327666	8	zinc_acexamate	1613,1627	Runx2	1676,1681	zinc acexamate	Runx2	MESH:C018802	12393(Tax:10090)	Chemical	Gene	have|nsubj|START_ENTITY have|dobj|effect effect|nmod|END_ENTITY	Culture with beta-alanyl-L-histidinato_zinc -LRB- 10 -LRB- -5 -RRB- M -RRB- caused a significant increase in Runx2 or regucalcin mRNA expressions , while zinc_acexamate -LRB- 10 -LRB- -5 -RRB- M -RRB- did not have a significant effect on Runx2 , OPG , ZIP1 , or regucalcin mRNA expressions .
19811107	0	zinc_oxide	19,29	Th2	33,36	zinc oxide	Th2	MESH:D015034	15111(Tax:10090)	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Adjuvant effect of zinc_oxide on Th2 but not Th1 immune responses in mice .
20194077	0	zinc_oxide	39,49	interleukin_8	71,84	zinc oxide	interleukin 8	MESH:D015034	3576	Chemical	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Phosphorylation of p65 is required for zinc_oxide nanoparticle-induced interleukin_8 expression in human bronchial epithelial cells .
10066279	0	zinc_selenite	20,33	metallothionein-III	52,71	zinc selenite	metallothionein-III	MESH:C118202	117038(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|mRNA mRNA|compound|END_ENTITY	The distribution of zinc_selenite and expression of metallothionein-III mRNA in the spinal cord and dorsal root ganglia of the rat suggest a role for zinc in sensory transmission .
8974046	0	zinterol	34,42	Beta_2-adrenoceptor	0,19	zinterol	Beta 2-adrenoceptor	MESH:C002904	154	Chemical	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Beta_2-adrenoceptor activation by zinterol causes protein phosphorylation , contractile effects and relaxant effects through a cAMP pathway in human atrium .
8098163	0	zinterol	40,48	beta-2	14,20	zinterol	beta-2	MESH:C002904	10242	Chemical	Gene	START_ENTITY|nsubj|Effect Effect|nmod|agonist agonist|amod|END_ENTITY	Effect of the beta-2 adrenergic agonist zinterol on norepinephrine turnover .
18656896	0	ziprasidone	24,35	BDNF	90,94	ziprasidone	BDNF	MESH:C092292	24225(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY END_ENTITY|nsubj|effects	Differential effects of ziprasidone and haloperidol on immobilization stress-induced mRNA BDNF expression in the hippocampus and neocortex of rats .
21063130	0	ziprasidone	24,35	CRF	85,88	ziprasidone	CRF	MESH:C092292	81648(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|compound|END_ENTITY	Differential effects of ziprasidone and haloperidol on immobilization-stress-induced CRF mRNA expression in the hypothalamic paraventricular nucleus of rats .
16328378	0	ziprasidone	15,26	c-Fos	39,44	ziprasidone	c-Fos	MESH:C092292	314322(Tax:10116)	Chemical	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|amod|END_ENTITY	The effects of ziprasidone on regional c-Fos expression in the rat forebrain .
22447799	0	ziprasidone	94,105	prolactin	6,15	ziprasidone	prolactin	MESH:C092292	5617	Chemical	Gene	treated|nmod|START_ENTITY treated|nsubj|levels levels|compound|END_ENTITY	Serum prolactin levels and the acute-phase efficacy in drug-na ve schizophrenia treated with ziprasidone and olanzapine -LRB- translated version -RRB- .
12776518	0	zishuijianghuoyin	11,28	AngII_receptor	57,71	zishuijianghuoyin	AngII receptor	null	24180(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|nmod|mRNA mRNA|compound|END_ENTITY	-LSB- Effect of zishuijianghuoyin on expression of lymphocyte AngII_receptor -LRB- AT-1 -RRB- mRNA of experimental hypertension rats -RSB- .
17081085	0	zofenopril	25,35	ACE	11,14	zofenopril	ACE	null	1636	Chemical	Gene	START_ENTITY|nsubj|Use Use|nmod|inhibitor inhibitor|compound|END_ENTITY	Use of the ACE inhibitor zofenopril in the treatment of ischemic_heart_disease .
20848272	0	zofenopril	20,30	ACE	49,52	zofenopril	ACE	null	100715217	Chemical	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Differences between zofenopril and ramipril , two ACE inhibitors , on cough induced by citric_acid in guinea_pigs : role of bradykinin and PGE2 .
7990904	0	zofenopril	58,68	angiotensin-converting-enzyme	18,47	zofenopril	angiotensin-converting-enzyme	null	1636	Chemical	Gene	START_ENTITY|nsubj|effect effect|nmod|inhibitor inhibitor|amod|END_ENTITY	The effect of the angiotensin-converting-enzyme inhibitor zofenopril on mortality and morbidity after anterior_myocardial_infarction .
2484083	0	zofenopril	28,38	angiotensin_I_converting_enzyme	56,87	zofenopril	angiotensin I converting enzyme	null	24310(Tax:10116)	Chemical	Gene	pharmacology|nmod|START_ENTITY pharmacology|appos|inhibitor inhibitor|nmod|END_ENTITY	Preclinical pharmacology of zofenopril , an inhibitor of angiotensin_I_converting_enzyme .
25039147	0	zoledronate	31,42	RANKL	22,27	zoledronate	RANKL	MESH:C088658	21943(Tax:10090)	Chemical	Gene	-LSB-|nmod|START_ENTITY -LSB-|dobj|effect effect|nmod|END_ENTITY	-LSB- The rescue effect of RANKL on zoledronate induced acid inhibition of osteoclastogenesis and gene expression of NF-kappaB_p50 and c-Jun -RSB- .
26099999	0	zoledronate	25,36	bone_morphogenetic_protein_2	88,116	zoledronate	bone morphogenetic protein 2	MESH:C088658	650	Chemical	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The inhibitory effect of zoledronate on early-stage osteoinduction by recombinant human bone_morphogenetic_protein_2 in an osteoporosis model .
16904974	0	zoledronate	12,23	neuroblastoma	32,45	zoledronate	neuroblastoma	MESH:C088658	230972(Tax:10090)	Chemical	Gene	Efficacy|nmod|START_ENTITY Efficacy|nmod|END_ENTITY	Efficacy of zoledronate against neuroblastoma .
25489573	0	zoledronate	10,21	vascular_endothelial_growth_factor-a	43,79	zoledronate	vascular endothelial growth factor-a	MESH:C088658	7422	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	Effect of zoledronate on the expression of vascular_endothelial_growth_factor-a by articular chondrocytes and synovial cells : an in vitro study .
20015195	0	zoledronic_acid	63,78	Cenp-F	24,30	zoledronic acid	Cenp-F	MESH:C088658	1063	Chemical	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	The kinetochore protein Cenp-F is a potential novel target for zoledronic_acid in breast_cancer cells .
26515701	0	zoledronic_acid	119,134	Dickkopf-1	27,37	zoledronic acid	Dickkopf-1	MESH:C088658	22943	Chemical	Gene	START_ENTITY|nsubj|suppression suppression|nmod|END_ENTITY	Potentiated suppression of Dickkopf-1 in breast_cancer by combined administration of the mevalonate pathway inhibitors zoledronic_acid and statins .
18494934	0	zoledronic_acid	63,78	Farnesyl_diphosphate_synthase	0,29	zoledronic acid	Farnesyl diphosphate synthase	MESH:C088658	2224	Chemical	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	Farnesyl_diphosphate_synthase is involved in the resistance to zoledronic_acid of osteosarcoma cells .
22166808	0	zoledronic_acid	65,80	KLF2_and_6_and_Ki-67	22,42	zoledronic acid	KLF2 and 6 and Ki-67	MESH:C088658	10365;1316	Chemical	Gene	targets|nmod|START_ENTITY targets|nsubj|END_ENTITY	Kr ppel-like factors KLF2_and_6_and_Ki-67 are direct targets of zoledronic_acid in MCF-7 cells .
18506177	0	zoledronic_acid	88,103	PTH	43,46	zoledronic acid	PTH	MESH:C088658	5741	Chemical	Gene	administration|nmod|START_ENTITY END_ENTITY|nmod|administration	Changes of bone turnover markers and serum PTH after night or morning administration of zoledronic_acid in breast_cancer patients with bone metastases .
22126137	0	zoledronic_acid	19,34	prostate-specific_antigen	44,69	zoledronic acid	prostate-specific antigen	MESH:C088658	354	Chemical	Gene	changes|amod|START_ENTITY changes|amod|END_ENTITY	Additive effect of zoledronic_acid on serum prostate-specific_antigen changes for hormone-sensitive prostate_cancer patients with bone metastasis treated by combined androgen blockade .
16475674	0	zoledronic_acid	11,26	proteinase	30,40	zoledronic acid	proteinase	MESH:C088658	100616101	Chemical	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	Effects of zoledronic_acid on proteinase plasma levels in patients with bone metastases .
23430984	0	zolmitriptan	81,93	5-HT1B	52,58	zolmitriptan	5-HT1B	MESH:C089750	3351	Chemical	Gene	occupancy|nmod|START_ENTITY occupancy|nummod|END_ENTITY	A PET study with -LSB- 11C -RSB- AZ10419369 to determine brain 5-HT1B receptor occupancy of zolmitriptan in healthy male volunteers .
19000364	0	zolmitriptan	45,57	CYP3A2	27,33	zolmitriptan	CYP3A2	MESH:C089750	266682(Tax:10116)	Chemical	Gene	rats|nmod|START_ENTITY induction|nmod|rats induction|nmod|END_ENTITY	Male-specific induction of CYP3A2 in rats by zolmitriptan .
19036425	0	zolmitriptan	133,145	MK-0974	29,36	zolmitriptan	MK-0974	MESH:C089750	1477075(Tax:190192)	Chemical	Gene	Efficacy|nmod|START_ENTITY Efficacy|nmod|END_ENTITY	Efficacy and tolerability of MK-0974 -LRB- telcagepant -RRB- , a new oral antagonist of calcitonin_gene-related_peptide receptor , compared with zolmitriptan for acute migraine : a randomised , placebo-controlled , parallel-treatment trial .
12469329	0	zolpidem	10,18	P-glycoprotein	83,97	zolpidem	P-glycoprotein	MESH:C049109	5243	Chemical	Gene	Effect|nmod|START_ENTITY mediated|nsubj|Effect mediated|nmod|END_ENTITY	Effect of zolpidem on human cytochrome_P450 activity , and on transport mediated by P-glycoprotein .
12469329	0	zolpidem	10,18	cytochrome_P450	28,43	zolpidem	cytochrome P450	MESH:C049109	4051	Chemical	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effect of zolpidem on human cytochrome_P450 activity , and on transport mediated by P-glycoprotein .
18359199	0	zonisamide	26,36	CA3	52,55	zonisamide	CA3	MESH:C022189	100306971(Tax:10141)	Chemical	Gene	START_ENTITY|nmod|neurons neurons|compound|END_ENTITY	Antiepileptic activity of zonisamide on hippocampal CA3 neurons does not depend on carbonic anhydrase inhibition .
18693129	0	zonisamide	11,21	c-Fos	25,30	zonisamide	c-Fos	MESH:C022189	314322(Tax:10116)	Chemical	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effects of zonisamide on c-Fos expression under conditions of tacrine-induced tremulous_jaw_movements in rats : a potential mechanism underlying its anti-parkinsonian tremor effect .
15161679	0	zosuquidar_trihydrochloride	54,81	P-glycoprotein	28,42	zosuquidar trihydrochloride	P-glycoprotein	MESH:C095179	5243	Chemical	Gene	trial|appos|START_ENTITY trial|nmod|inhibitor inhibitor|amod|END_ENTITY	A Phase I trial of a potent P-glycoprotein inhibitor , zosuquidar_trihydrochloride -LRB- LY335979 -RRB- , administered intravenously in combination with doxorubicin in patients with advanced malignancy .
20535929	0	zuoguiyin	11,20	follicle-stimulating_hormone_receptor	50,87	zuoguiyin	follicle-stimulating hormone receptor	null	25449(Tax:10116)	Chemical	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of zuoguiyin on the expression of ovarian follicle-stimulating_hormone_receptor in rats during peri-menopausal period -RSB- .